From 5bda6d6dd2cd053c498331450e179343b9c4ac9e Mon Sep 17 00:00:00 2001 From: Eirinits Date: Wed, 27 Mar 2024 16:56:01 +0100 Subject: [PATCH 01/10] add organism arg for phosphorylation network --- omniflow_project/_inputs/resources.py | 10 +++++----- 1 file changed, 5 insertions(+), 5 deletions(-) diff --git a/omniflow_project/_inputs/resources.py b/omniflow_project/_inputs/resources.py index ab59f11..43735c2 100644 --- a/omniflow_project/_inputs/resources.py +++ b/omniflow_project/_inputs/resources.py @@ -106,15 +106,15 @@ def is_inhibition(effect): self.add_database(transformed_df) return - def process_psp_interactions(self, kinase_int_file, phospho_effect_file, expand=False): + def process_psp_interactions(self, kinase_int_file, phospho_effect_file, organism, expand=False): """ Loads files from PhoshpositePlus (PSP), parses the files to create sign interactions based on the effect of phosphorylation on protein activities and creates an interaction dataframe based on the Omnipath interaction format. """ kinase_int = pd.read_csv(kinase_int_file) phospho_effect = pd.read_csv(phospho_effect_file) - # Filter kinase_int dataframe to include only interactions involving human organisms - kinase_int_filtered = kinase_int.loc[(kinase_int['KIN_ORGANISM'] == 'human') & (kinase_int['SUB_ORGANISM'] == 'human')] + # Filter kinase_int dataframe to include only human interactions + kinase_int_filtered = kinase_int.loc[(kinase_int['KIN_ORGANISM'] == organism) & (kinase_int['SUB_ORGANISM'] == organism)] # Concatenate SUB_GENE and SUB_MOD_RSD columns separated by "_" kinase_int_filtered['target'] = kinase_int_filtered['SUB_GENE'] + '_' + kinase_int_filtered['SUB_MOD_RSD'] @@ -129,8 +129,8 @@ def process_psp_interactions(self, kinase_int_file, phospho_effect_file, expand= 'consensus_inhibition': False, # Assuming no data provided, set all to False }) - # Filter phospho_effect dataframe to include only interactions involving human organisms - phospho_effect_filtered = phospho_effect.loc[phospho_effect['ORGANISM'] == 'human'] + # Filter phospho_effect dataframe to include only human interactions + phospho_effect_filtered = phospho_effect.loc[phospho_effect['ORGANISM'] == organism] # Keep only MOD_RSD entries with "-p" suffix and remove it phospho_effect_filtered['MOD_RSD'] = phospho_effect_filtered['MOD_RSD'].apply(lambda x: x[:-2] if x.endswith('-p') else x) From c6ecd3ffc47e2fde6937877f416cfe530a5c1060 Mon Sep 17 00:00:00 2001 From: Eirinits Date: Wed, 27 Mar 2024 17:05:23 +0100 Subject: [PATCH 02/10] add organism arg to process_psp_interactions --- omniflow_project/_inputs/resources.py | 10 +++++----- 1 file changed, 5 insertions(+), 5 deletions(-) diff --git a/omniflow_project/_inputs/resources.py b/omniflow_project/_inputs/resources.py index eb7b2d9..bc461e6 100644 --- a/omniflow_project/_inputs/resources.py +++ b/omniflow_project/_inputs/resources.py @@ -113,7 +113,7 @@ def form_complex(effect): return - def process_psp_interactions(self, kinase_int_file, phospho_effect_file, expand=False): + def process_psp_interactions(self, kinase_int_file, phospho_effect_file, organism, expand=False): """ Loads files from PhoshpositePlus (PSP), parses the files to create sign interactions based on the effect of phosphorylation on protein activities and creates an interaction dataframe based on the Omnipath interaction format. @@ -121,8 +121,8 @@ def process_psp_interactions(self, kinase_int_file, phospho_effect_file, expand= kinase_int = pd.read_csv(kinase_int_file) phospho_effect = pd.read_csv(phospho_effect_file) - # Filter kinase_int dataframe to include only interactions involving human organisms - kinase_int_filtered = kinase_int.loc[(kinase_int['KIN_ORGANISM'] == 'human') & (kinase_int['SUB_ORGANISM'] == 'human')] + # Filter kinase_int dataframe to include only interactions from specified organisms + kinase_int_filtered = kinase_int.loc[(kinase_int['KIN_ORGANISM'] == organism) & (kinase_int['SUB_ORGANISM'] == organism)] # Concatenate SUB_GENE and SUB_MOD_RSD columns separated by "_" kinase_int_filtered['target'] = kinase_int_filtered['SUB_GENE'] + '_' + kinase_int_filtered['SUB_MOD_RSD'] @@ -137,8 +137,8 @@ def process_psp_interactions(self, kinase_int_file, phospho_effect_file, expand= 'consensus_inhibition': False, # Assuming no data provided, set all to False }) - # Filter phospho_effect dataframe to include only interactions involving human organisms - phospho_effect_filtered = phospho_effect.loc[phospho_effect['ORGANISM'] == 'human'] + # Filter phospho_effect dataframe to include only interactions from specified organisms + phospho_effect_filtered = phospho_effect.loc[phospho_effect['ORGANISM'] == organism] # Keep only MOD_RSD entries with "-p" suffix and remove it phospho_effect_filtered['MOD_RSD'] = phospho_effect_filtered['MOD_RSD'].apply(lambda x: x[:-2] if x.endswith('-p') else x) From 57f09501eebe84e013c95de346601cdabd845aa7 Mon Sep 17 00:00:00 2001 From: Eirinits Date: Thu, 4 Apr 2024 11:09:58 +0200 Subject: [PATCH 03/10] Add phosphositeplus data to _data --- Kinase_Substrate_Dataset | 23381 ------------------------------------- Regulatory_sites | 20194 -------------------------------- 2 files changed, 43575 deletions(-) delete mode 100644 Kinase_Substrate_Dataset delete mode 100644 Regulatory_sites diff --git a/Kinase_Substrate_Dataset b/Kinase_Substrate_Dataset deleted file mode 100644 index 0f4691a..0000000 --- a/Kinase_Substrate_Dataset +++ /dev/null @@ -1,23381 +0,0 @@ -GENE KINASE KIN_ACC_ID KIN_ORGANISM SUBSTRATE SUB_GENE_ID SUB_ACC_ID SUB_GENE SUB_ORGANISM SUB_MOD_RSD SITE_GRP_ID SITE_+/-7_AA DOMAIN IN_VIVO_RXN IN_VITRO_RXN CST_CAT# -Dyrk2 DYRK2 Q5U4C9 mouse NDEL1 83431 Q9ERR1 Ndel1 mouse S336 1869686801 LGSsRPSsAPGMLPL X -Pak2 PAK2 Q64303 rat MEK1 170851 Q01986 Map2k1 rat S298 448284 RtPGRPLsSYGMDSR Pkinase X 9128; 98195 -Pak2 PAK2 Q64303 rat PRKD1 85421 Q9WTQ1 Prkd1 rat S203 449896 GVRRRRLsNVsLTGL X -Pak2 PAK2 Q64303 rat prolactin 24683 P01237 Prl rat S206 451732 IRCLRRDsHKVDNYL Hormone_1 X -Pak2 PAK2 Q64303 rat prolactin 5617 P01236 PRL human S207 451732 LHCLRRDsHKIDNYL Hormone_1 X -EIF2AK1 HRI Q9BQI3 human eIF2-alpha 54318 P68101 Eif2s1 rat S52 447635 MILLSELsRRRIRSI S1 X 3597; 9721; 3398; 5199; 53085; 95797 -EIF2AK1 HRI Q9BQI3 human eIF2-alpha 100339093 P83268 EIF2S1 rabbit S51 447635 RILLsELsR______ S1 X 3398; 5199; 95797 -EIF2AK1 HRI Q9BQI3 human eIF2-alpha 1965 P05198 EIF2S1 human S52 447635 MILLsELsRRRIRsI S1 X 3597; 9721; 3398; 5199; 53085; 95797 -EIF2AK1 HRI Q9BQI3 human eIF2-alpha 1965 P05198 EIF2S1 human S49 450210 IEGMILLsELsRRRI S1 X -PRKCD PKCD Q05655 human syndecan-4 24771 P34901 Sdc4 rat S183 449863 MKKKDEGsYDLGKKP Syndecan X X -PRKCD PKCD Q05655 human ANKRD54 223690 Q91WK7 Ankrd54 mouse S14 239773904 GADDESRsGRsssDG X -PRKCD PKCD Q05655 human HDAC5 10014 Q9UQL6 HDAC5 human S259 447995 FPLRkTAsEPNLKVR X 3443 -PRKCD PKCD Q05655 human PTPRA iso6 5786 P18433-2 PTPRA human S204 447612 PLLARSPsTNRKYPP X -PRKCD PKCD Q05655 human Bcl-2 596 P10415 BCL2 human S70 448395 RDPVARtsPLQtPAA X 2834; 2827 -PRKCD PKCD Q05655 human hnRNP K 3190 P61978 HNRNPK human S302 457408 GrGGrGGsrArNLPL X X -PRKCD PKCD Q05655 human NHE1 6548 P19634 SLC9A1 human S648 3880766 KTRQRLRsYNRHtLV NEXCaM_BD X -PRKCD PKCD Q05655 human SHOC2 8036 Q9UQ13 SHOC2 human T71 34669125 VAFSVDNtIKRPNPA X -PRKCD PKCD Q05655 human TNNI3 21954 P48787 Tnni3 mouse T144 451483 RGKFKRPtLRRVRIs Troponin X -PRKCD PKCD Q05655 human IRS1 25467 P35570 Irs1 rat S612 447562 DDGyMPMsPGVAPVP X 3193; 2386; 3203 -PRKCD PKCD Q05655 human BVR 644 P53004 BLVRA human S237 4774274 sFHFksGsLENVPNV Biliv-reduc_cat X X -PRKCD PKCD Q05655 human MUC1 4582 P15941 MUC1 human T1224 455682 RyVPPsstDRsPyEK X X -PRKCD PKCD Q05655 human ADD1 118 P35611 ADD1 human S726 449829 KKKFRtPsFLKKsKK X X -PRKCD PKCD Q05655 human TNNT2 286816 P13789 TNNT2 cow T191 449038 GYIQKAQtERKsGKR Troponin X -PRKCD PKCD Q05655 human p47phox 653361 P14598 NCF1 human S370 451730 PAVPPRPsADLILNR p47_phox_C X -PRKCD PKCD Q05655 human IRS1 25467 P35570 Irs1 rat S307 447558 TEsITATsPASMVGG X 2381 -PRKCD PKCD Q05655 human FBXO25 26260 Q8TCJ0 FBXO25 human S178 37043701 DLLQDLSsTLCILIR X X -PRKCD PKCD Q05655 human ENOX2 10495 Q16206 ENOX2 human S504 25602101 ENLKEKEsCASRLCA X X -PRKCD PKCD Q05655 human DRP1 114114 O35303 Dnm1l rat S635 454690 PIPIMPAsPQKGHAV X X 3455; 4494; 63940 -PRKCD PKCD Q05655 human MARK2 2011 Q7KZI7 MARK2 human T596 453427 rGVssRstFHAGQLR X X -PRKCD PKCD Q05655 human MYBPC3 17868 O70468 Mybpc3 mouse S302 471081 sLLKKRDsFRRDskL X -PRKCD PKCD Q05655 human TNNI3 7137 P19429 TNNI3 human T143 451483 RGKFKRPtLRrVrIs Troponin X -PRKCD PKCD Q05655 human FRA1 8061 P15407 FOSL1 human T217 1270902 LEPEALHtPTLMTtP X -PRKCD PKCD Q05655 human BEST1 7439 O76090 BEST1 human S358 9720901 SAQFRRAsFMGSTFN X -PRKCD PKCD Q05655 human P70S6KB 6199 Q9UBS0 RPS6KB2 human S473 450071 PPSGTKKsKRGRGRP X X -PRKCD PKCD Q05655 human p40phox 4689 Q15080 NCF4 human S315 448265 RQARGLPsQKRLFPW PB1 X -PRKCD PKCD Q05655 human p47phox 653361 P14598 NCF1 human S303 449405 RGAPPRRssIRNAHs NECFESHC X -PRKCD PKCD Q05655 human CARD9 64170 Q9H257 CARD9 human T231 23017301 CKVERKHtLKLRHAM X X -PRKCD PKCD Q05655 human RGS9 281453 O46469 RGS9 cow S475 449027 MSKLDRRsQLRKEPP X -PRKCD PKCD Q05655 human ITGB2 3689 P05107 ITGB2 human T758 448533 NPLFksAtttVMNPk Integrin_b_cyt X -PRKCD PKCD Q05655 human PKCD 5580 Q05655 PRKCD human T218 7445829 TAANSRDtIFQkERF X -PRKCD PKCD Q05655 human TRPV4 59341 Q9HBA0 TRPV4 human S162 10272403 FDIVSRGsTADLDGL X -PRKCD PKCD Q05655 human L-plastin 3936 P13796 LCP1 human S5 450852 ___MARGsVsDEEMM X -PRKCD PKCD Q05655 human SQSTM1 8878 Q13501 SQSTM1 human S349 14580829 sskEVDPstGELQsL X X 95697; 16177; 12074 -PRKCD PKCD Q05655 human K8 3856 P05787 KRT8 human S74 448539 tVNQsLLsPLVLEVD Keratin_2_head X -PRKCD PKCD Q05655 human GAPDH 2597 P04406 GAPDH human T246 23109023 NVsVVDLtCrLEkPA Gp_dh_C X X -PRKCD PKCD Q05655 human GAPDH 2597 P04406 GAPDH human S241 9425118 rVPtANVsVVDLtCr Gp_dh_C X -PRKCD PKCD Q05655 human NRG1 iso6 3084 Q02297-6 NRG1 human S286 28076401 LHDRLRQsLRSERNN Neuregulin X -PRKCD PKCD Q05655 human p47phox 653361 P14598 NCF1 human S328 449404 QDAYRRNsVRFLQQR NECFESHC X -PRKCD PKCD Q05655 human DAP3 7818 P51398 DAP3 human S31 2226208 MGTQARQsIAAHLDN X -PRKCD PKCD Q05655 human STAT1 6772 P42224 STAT1 human S727 447753 TDNLLPMsPEEFDEV STAT1_TAZ2bind X 9177; 8826; 62390 -PRKCD PKCD Q05655 human p40phox 4689 Q15080 NCF4 human T154 448266 LRRLRPRtRKVKSVs X 4311 -PRKCD PKCD Q05655 human PKCD 5580 Q05655 PRKCD human S503 4270924 kENIFGEsRAstFCG Pkinase X -PRKCD PKCD Q05655 human PPAR-alpha 25747 P37230 Ppara rat T129 457548 CKGFFRRtIRLKLAY zf-C4 X -PRKCD PKCD Q05655 human S6 6194 P62753 RPS6 human S235 448092 IAKRRRLssLRAsts X 5006; 4856; 4857; 4858; 4851; 4803; 2211; 3945; 3985; 5316; 4854; 8520; 48319; 40643; 9865; 38573; 14733; 27036; 34411; 62016; 62788; 81736; 97935; 99457; 15448 -PRKCD PKCD Q05655 human ITGB2 3689 P05107 ITGB2 human S745 448532 FEkEKLksQWNNDNP Integrin_b_cyt X -PRKCD PKCD Q05655 human DBI 100008823 Q8WN94 DBI rabbit T65 2833502 AWNELKGtSKESAMR ACBP X -PRKCD PKCD Q05655 human PKCD 5580 Q05655 PRKCD human S299 483986 NQVtQRAsRRsDsAs X X -PRKCD PKCD Q05655 human SLC29A1 2030 Q99808 SLC29A1 human S281 21326706 QPTNESHsIkAILkN Nucleoside_tran X -PRKCD PKCD Q05655 human PPAR-alpha 25747 P37230 Ppara rat S110 457547 RICGDKAsGYHYGVH zf-C4 X -PRKCD PKCD Q05655 human TIRAP 114609 P58753 TIRAP human Y106 463809 AAQDLVSyLEGSTAS TIR_2 X -PRKCD PKCD Q05655 human TNNT2 286816 P13789 TNNT2 cow T200 451556 RKsGKRQtEREKKKK Troponin X -PRKCD PKCD Q05655 human DAP3 7818 P51398 DAP3 human S280 2226203 tLKREDksPIAPEEL DAP3 X -PRKCD PKCD Q05655 human Cortactin 2017 Q14247 CTTN human S405 447700 KtQtPPVsPAPQPtE X -PRKCD PKCD Q05655 human DAB2 1601 P98082 DAB2 human S24 451211 QAAPKAPsKKEKKKG X -PRKCD PKCD Q05655 human PTPN22 26191 Q9Y2R2 PTPN22 human S35 1725300 FLkLkRQsTKYKADK X X -PRKCD PKCD Q05655 human PRKD1 5587 Q15139 PRKD1 human S742 448590 GEksFRRsVVGtPAy Pkinase X X -PRKCD PKCD Q05655 human PKCD 5580 Q05655 PRKCD human S302 478497 tQRAsRRsDsAssEP X -PRKCD PKCD Q05655 human p47phox 653361 P14598 NCF1 human S348 451728 PGPQsPGsPLEEERQ X X -PRKCD PKCD Q05655 human eNOS 287024 P29473 NOS3 cow S1179 447884 TSRIRtQsFsLQERH X 9570 -PRKCD PKCD Q05655 human BVR 644 P53004 BLVRA human S230 478716 LKRNRyLsFHFksGs Biliv-reduc_cat X X -PRKCD PKCD Q05655 human PKCD 5580 Q05655 PRKCD human S645 448591 LNEkARLsysDKNLI Pkinase_C X 9376 -PRKCD PKCD Q05655 human CACNA1C 100101555 P15381 CACB rabbit S1674 480102 QGLVGKPsQRNALSL X -PRKCD PKCD Q05655 human HMGA1 117062 Q8K585 Hmga1 rat S44 479856 PGTALVGsQKEPSEV X -PRKCD PKCD Q05655 human TNNI3 511094 P08057 TNNI3 cow S24 448423 PPPVRRRssANYRAY Troponin-I_N X -PRKCD PKCD Q05655 human DAP3 7818 P51398 DAP3 human T237 2226209 ItRVRNAtDAVGIVL DAP3 X -PRKCD PKCD Q05655 human PKCD 5580 Q05655 PRKCD human S304 483987 RAsRRsDsAssEPVG X X -PRKCD PKCD Q05655 human FGF1 2246 P05230 FGF1 human S131 31954800 VGLKKNGsCKRGPRT FGF X X -PRKCD PKCD Q05655 human PKCD 5580 Q05655 PRKCD human T295 4272376 AEALNQVtQRAsRRs X -PRKCD PKCD Q05655 human NRF2 18024 Q60795 Nfe2l2 mouse S40 450082 SREVFDFsQRQKDYE X -PRKCD PKCD Q05655 human AML3 12393 Q08775 Runx2 mouse S326 460575 KLDDSKPsLFSDRLS X -PRKCD PKCD Q05655 human SMPD1 6609 P17405 SMPD1 human S510 477185 DGNYSGSsHVVLDHE ASMase_C X X -PRKCD PKCD Q05655 human H3 8350 P68431 H3C1 human T45 455679 PHryrPGtVALrEIR Histone X X -PRKCD PKCD Q05655 human CHAT iso3 1103 P28329-3 CHAT human S476 454037 HKAAVPAsEKLLLLK Carn_acyltransf X -PRKCD PKCD Q05655 human CYBA 1535 P13498 CYBA human T147 7103047 ERPQIGGtIkQPPsN Cytochrom_B558a X -PRKCD PKCD Q05655 human PTPRA iso6 5786 P18433-2 PTPRA human S180 447611 QAGSHSNsFRLSNGR X -PRKCD PKCD Q05655 human p53 7157 P04637 TP53 human S46 447536 AMDDLMLsPDDIEQW TAD2 X X 2521 -PRKCD PKCD Q05655 human PR 5241 P06401 PGR human S400 449842 GAEAsARsPRSYLVA Prog_receptor X -PRKCD PKCD Q05655 human PREX1 57580 Q8TCU6 PREX1 human S313 18704701 RVtGsKKsTKRTKsI X X -PRKCD PKCD Q05655 human TACE 6868 P78536 ADAM17 human T735 449804 kPFPAPQtPGRLQPA X -PRKCD PKCD Q05655 human Ebp1 288778 Q6AYD3 Pa2g4 rat S360 478276 ELKALLQsSASRKTQ X -PRKCD PKCD Q05655 human CDH1 999 P12830 CDH1 human T790 55578700 TRNDVAPtLMsVPRy X X -PRKCD PKCD Q05655 human ANKRD54 223690 Q91WK7 Ankrd54 mouse S19 239773906 SRsGRsssDGECAVA X -PRKCD PKCD Q05655 human C5aR 728 P21730 C5AR1 human S334 448819 sVVREsKsFTRsTVD X -PRKCD PKCD Q05655 human IRS1 3667 P35568 IRS1 human S574 451681 RLPGHRHsAFVPTRs X -PRKCD PKCD Q05655 human PLSCR3 57048 Q9NRY6 PLSCR3 human T21 457790 PPPPYPVtPGYPEPA X X -PRKCD PKCD Q05655 human GLRB 14658 P48168 Glrb mouse S425 2048205 NDFSIVGsLPRDFEL Neur_chan_memb X -PRKCD PKCD Q05655 human NADK 65220 O95544 NADK human S46 1210510 RGRAKsrsLsAsPAL X -PRKCD PKCD Q05655 human TNNI3 511094 P08057 TNNI3 cow S79 451839 GEKGRALsTRCQPLE Troponin X -PRKCD PKCD Q05655 human TRPV4 59341 Q9HBA0 TRPV4 human T175 10272405 GLLPFLLtHKKRLTD X -PRKCD PKCD Q05655 human DBI 100008823 Q8WN94 DBI rabbit T42 2833500 AtVGDVNtERPGMLD ACBP X -PRKCD PKCD Q05655 human IRS1 25467 P35570 Irs1 rat S24 455604 GYLRKPKsMHKRFFV PH X -PRKCD PKCD Q05655 human PPP1R14A 94274 Q96A00 PPP1R14A human T38 449098 QkRHARVtVkYDRRE PP1_inhibitor X -PRKCD PKCD Q05655 human p47phox 653361 P14598 NCF1 human S320 451726 QRsRKRLsQDAYRRN NECFESHC X -PRKCD PKCD Q05655 human p47phox 653361 P14598 NCF1 human S359 451729 EERQtQRsKPQPAVP p47_phox_C X -PRKCD PKCD Q05655 human TNNI3 511094 P08057 TNNI3 cow S44 450690 AKKKSKIsAsRKLQL X -PRKCD PKCD Q05655 human G6PD iso3 2539 P11413-3 G6PD human S210 15207801 FGRDLQSsDRLSNHI G6PD_N X X -PRKCD PKCD Q05655 human CACNA1C 100101555 P15381 CACB rabbit S1928 455278 ASLGRRAsFHLECLK CAC1F_C X -PRKCD PKCD Q05655 human NADK 65220 O95544 NADK human S64 467326 kEFRRtRsLHGPCPV X -PRKCD PKCD Q05655 human CDK5 1020 Q00535 CDK5 human T77 900975700 LHsDkKLtLVFEFCD Pkinase X -PRKCD PKCD Q05655 human LIMK2 3985 P53671 LIMK2 human S283 456167 EGtLRRRsLRRsNsI X X -PRKCD PKCD Q05655 human TNNT2 286816 P13789 TNNT2 cow T281 451557 TRGKAKVtGRWK___ X -PRKCD PKCD Q05655 human TNNI3 511094 P08057 TNNI3 cow T145 451483 RGKFKRPtLRRVRIS Troponin X -PRKCD PKCD Q05655 human DAP3 7818 P51398 DAP3 human S185 2226206 FDQPLEAstWLkNFk DAP3 X -PRKCD PKCD Q05655 human EAR-2 2063 P10588 NR2F6 human S83 25802106 CKSFFKRsIRRNLsY zf-C4 X -PRKCD PKCD Q05655 human PIP5K1B 18719 P70181 Pip5k1b mouse S413 27461455 PSKKRCNsIAALKAT X -PRKCD PKCD Q05655 human p47phox 653361 P14598 NCF1 human S304 449406 GAPPRRssIRNAHsI NECFESHC X X -PRKCD PKCD Q05655 human NMDAR2B 24410 Q00960 Grin2b rat S1303 450171 NKLRRQHsyDtFVDL NMDAR2_C X 20274; 71335 -PRKCD PKCD Q05655 human HVCN1 iso4 84329 Q96D96-4 HVCN1 human S77 12064203 GMLRKLFsSHRFQVI X -PRKCD PKCD Q05655 human CACNA1C 100101555 P15381 CACB rabbit S528 486358 ARLAHRIsKSKFsRY X -PRKCD PKCD Q05655 human TNNI3 7137 P19429 TNNI3 human S23 448423 PAPIRRRssNyRAyA Troponin-I_N X 4004 -PRKCD PKCD Q05655 human IRS1 3667 P35568 IRS1 human S323 451399 MVGGKPGsFRVRAss X 5610 -PRKCD PKCD Q05655 human gp130 3572 P40189 IL6ST human T890 455688 GQVERFEtVGMEAAt X X -PRKCD PKCD Q05655 human TAGLN 25123 P31232 Tagln rat S181 469978 VIGLQMGsNrGAsQA Calponin X -PRKCD PKCD Q05655 human DAP3 7818 P51398 DAP3 human T186 2226207 DQPLEAstWLkNFkT DAP3 X -PRKCD PKCD Q05655 human PKCD 5580 Q05655 PRKCD human T141 1028305 EDEAkFPtMNRRGAI X -PRKCD PKCD Q05655 human RPS3 6188 P23396 RPS3 human S6 8046503 __MAVQIskkRkFVA X X -PRKCD PKCD Q05655 human ANKRD54 223690 Q91WK7 Ankrd54 mouse S17 239773905 DESRsGRsssDGECA X -PRKCD PKCD Q05655 human VRK1 22367 Q80X41 Vrk1 mouse S355 483969 SVKTRPAsKKRKKEA X X -PRKCD PKCD Q05655 human PRKD1 5587 Q15139 PRKD1 human S738 448589 ARIIGEksFRRsVVG Pkinase X X 2054 -PRKCD PKCD Q05655 human PLD2 5338 O14939 PLD2 human T566 15343400 FIQRWNFtKTTKAKy X X -PRKCD PKCD Q05655 human BAG3 9531 O95817 BAG3 human S187 12217052 sSSSSSAsLPsSGRs X X -PRKCD PKCD Q05655 human MCU 90550 Q8NE86 MCU human S92 27259017 VISVRLPsRRERCQF X -PRKCD PKCD Q05655 human CHAT iso3 1103 P28329-3 CHAT human S440 449057 VPTYESAsIRRFQEG Carn_acyltransf X -PRKCD PKCD Q05655 human FRA1 8061 P15407 FOSL1 human T227 50205700 LMTtPSLtPFtPSLV X -PRKCD PKCD Q05655 human HMGA1 117062 Q8K585 Hmga1 rat S64 3136103 PRGRPKGsKNKGTAK X -PRKCD PKCD Q05655 human SHC1 iso2 6464 P29353-2 SHC1 human S29 448791 EEWTRHGsFVNKPTR X X -PRKCD PKCD Q05655 human EGFR 1956 P00533 EGFR human T678 448053 RHIVRKRtLRRLLQE X 14343 -PRKCD PKCD Q05655 human HuR 1994 Q15717 ELAVL1 human S318 2246702 GDkILQVsFkTNkSH X X -PRKCD PKCD Q05655 human TIF1B 21849 Q62318 Trim28 mouse S473 452391 SGMkRsRsGEGEVSG X -PRKCD PKCD Q05655 human S6 6194 P62753 RPS6 human S236 448093 AKRRRLssLRAstsK X 5006; 4856; 4857; 4858; 4851; 4803; 2211; 3945; 3985; 5316; 4854; 8520; 48319; 40643; 9865; 38573; 14733; 27036; 34411; 62016; 62788; 81736; 97935; 99457; 15448 -PRKCD PKCD Q05655 human NRF2 4780 Q16236 NFE2L2 human S40 450082 SREVFDFsQRRkEYE X -PRKCD PKCD Q05655 human HAX1 10456 O00165 HAX1 human S210 37043700 QPkSYFksIsVtkIT X X -PRKCD PKCD Q05655 human RPS3 6188 P23396 RPS3 human T221 452652 kDEILPttPIsEQkG X X -PRKCD PKCD Q05655 human CTNNB1 1499 P35222 CTNNB1 human S715 25288326 GYRQDDPsyRsFHsG X X -PRKCD PKCD Q05655 human PRKD1 5587 Q15139 PRKD1 human S412 20615903 PLMRVVQsVKHTKRK X X -PRKCD PKCD Q05655 human IRS1 3667 P35568 IRS1 human S307 450190 TRRsRtEsItAtsPA X 2384; 2491 -PRKCD PKCD Q05655 human TNNT2 286816 P13789 TNNT2 cow S195 451755 KAQtERKsGKRQtER Troponin X -PRKCD PKCD Q05655 human GSK3A 2931 P49840 GSK3A human S21 448584 sGrARtssFAEPGGG X 9337; 9316; 9331; 5090; 9327; 8452; 8566 -PRKCD PKCD Q05655 human CXCR4 7852 P61073 CXCR4 human S324 6140803 LtsVsRGssLkILsk X 85578 -PRKCD PKCD Q05655 human HVCN1 iso4 84329 Q96D96-4 HVCN1 human T9 472529 SKFLRHFtVVGDDYH X -PRKCD PKCD Q05655 human TNNI3 7137 P19429 TNNI3 human S24 448424 APIRRRssNyRAyAt Troponin-I_N X 4004 -PRKCD PKCD Q05655 human PPP1R14B 26472 Q96C90 PPP1R14B human T57 1904503 VRRQGKVtVkYDRKE PP1_inhibitor X -PRKCD PKCD Q05655 human TSC2 7249 P49815 TSC2 human S939 448501 sFRARstsLNERPKs X X 3615 -PRKCD PKCD Q05655 human FCER1G 2207 P30273 FCER1G human S69 13310016 DGVytGLstRNQEty ITAM X -PRKCD PKCD Q05655 human TRPC6 22068 Q61143 Trpc6 mouse S448 15794302 KFVAHAAsFTIFLGL Ion_trans; TM X -PRKCD PKCD Q05655 human TBL1XR1 79718 Q9BZK7 TBL1XR1 human S123 2509601 AAAsQQGsAKNGENT X -PRKCD PKCD Q05655 human GSK3B 2932 P49841 GSK3B human S9 449111 SGRPRttsFAEsCkP X 9336; 9331; 9327; 9323; 9322; 9325; 5558; 8566; 79774; 8466; 25462; 14026; 14332; 14310; 14630 -PRKCD PKCD Q05655 human STAT3 6774 P40763 STAT3 human S727 448191 NtIDLPMsPrTLDSL X X 9134; 9136; 34911; 94994; 49081; 58978; 87544; 71958; 50804 -PRKCD PKCD Q05655 human AID 11628 Q9WVE0 Aicda mouse S3 20660600 _____MDsLLMKQKK X -PRKCD PKCD Q05655 human CXCR4 7852 P61073 CXCR4 human S325 3849622 tsVsRGssLkILskG X 85578 -PRKCD PKCD Q05655 human DRP1 10059 O00429 DNM1L human S616 454690 PIPIMPAsPQKGHAV X 3455; 4494; 63940 -PRKCD PKCD Q05655 human CACNA1C 100101555 P15381 CACB rabbit S533 453091 RIsKSKFsRYWRRWN X -PRKCD PKCD Q05655 human TRPV4 59341 Q9HBA0 TRPV4 human S189 10272404 DEEFREPsTGKTCLP X -PRKCD PKCD Q05655 human p300 2033 Q09472 EP300 human S89 447592 SELLRSGsSPNLNMG X X -PRKCD PKCD Q05655 human TSC2 7249 P49815 TSC2 human S932 4728973 DDtPEkDsFRARsts X X -PRKCD PKCD Q05655 human lamin A/C 4000 P02545 LMNA human S22 452604 QAsstPLsPtRItRL X 2026; 13448 -PRKCD PKCD Q05655 human FLI1 2313 Q01543 FLI1 human T312 6406002 TNGEFKMtDPDEVAR Ets X X -PRKCD PKCD Q05655 human Met 4233 P08581 MET human S985 450188 PHLDRLVsARsVsPt X -PRKCD PKCD Q05655 human TNNI3 511094 P08057 TNNI3 cow S46 450691 KKSKIsAsRKLQLKT X -PRKCD PKCD Q05655 human HuR 1994 Q15717 ELAVL1 human S221 478357 QAQrFrFsPMGVDHM X X -PRKCD PKCD Q05655 human IRS1 3667 P35568 IRS1 human S441 1990800 SPCDFRSsFRsVtPD X -PRKCD PKCD Q05655 human TACSTD2 4070 P09758 TACSTD2 human S322 470219 GELRkEPsL______ X -PRKCD PKCD Q05655 human ANKRD54 223690 Q91WK7 Ankrd54 mouse S18 239773903 ESRsGRsssDGECAV X -PRKCD PKCD Q05655 human BVR 644 P53004 BLVRA human S33 25526803 DLRNPHPsSAFLNLI GFO_IDH_MocA X X -PRKCD PKCD Q05655 human Ebp1 5036 Q9UQ80 PA2G4 human S360 478276 ELkALLQssAsRKtQ X X -PRKCD PKCD Q05655 human HVCN1 84329 Q96D96 HVCN1 human T29 472529 SKFLRHFtVVGDDyH X -PRKCD PKCD Q05655 human Catalase 847 P04040 CAT human S167 30259808 LFPSFIHsQKRNPQT Catalase X -PRKCD PKCD Q05655 human p73 iso2 7161 O15350-2 TP73 human S289 455781 GQVLGRRsFEGRICA P53 X X -PRKCD PKCD Q05655 human PPAR-alpha 25747 P37230 Ppara rat S179 457549 RFGRMPRsEKAKLKA X -PRKCD PKCD Q05655 human Src 6714 P12931 SRC human S12 448230 KSKPKDAsQRRRsLE X -PRKCD PKCD Q05655 human G6PD iso3 2539 P11413-3 G6PD human T266 15207800 NIACVILtFKEPFGT G6PD_C X X -PRKCD PKCD Q05655 human ARHGAP3 1124 P52757 CHN2 human S171 13790300 EKVsRRLsRsKNEPR X X -PRKCD PKCD Q05655 human RKIP 5037 P30086 PEBP1 human S153 448755 RGKFkVAsFRKKYEL PBP X -PRKCD PKCD Q05655 human SHOC2 8036 Q9UQ13 SHOC2 human S297 31905007 GLRYNRLsAIPRSLA LRR_8 X -PRKCD PKCD Q05655 human p47phox 653361 P14598 NCF1 human S315 451725 AHsIHQRsRKRLsQD NECFESHC X -PRKCD PKCD Q05655 human BVR 644 P53004 BLVRA human S21 25526801 VGVGRAGsVRMRDLR GFO_IDH_MocA X X -PRKCD PKCD Q05655 human TNNI3 511094 P08057 TNNI3 cow S25 448424 PPVRRRssANYRAYA Troponin-I_N X -PRKCD PKCD Q05655 human p47phox 653361 P14598 NCF1 human S379 451498 DLILNRCsEstKRKL p47_phox_C X X -PRKCD PKCD Q05655 human RASGRP3 25780 Q8IV61 RASGRP3 human T133 454419 YDWMRRVtQRKKVSK X -PRKCD PKCD Q05655 human HVCN1 84329 Q96D96 HVCN1 human S97 12064203 GMLRKLFsSHRFQVI X -PIM2 Pim2 Q9P1W9 human EIF4B 300253 Q5RKG9 Eif4b rat S406 470374 RPRERHPsWRsEETQ X 8151; 5399 -PIM2 Pim2 Q9P1W9 human PKM 5315 P14618 PKM human T454 23132420 RAPIIAVtRNPQtAR PK_C X X -PIM2 Pim2 Q9P1W9 human FOXP3 20371 Q99JB6 Foxp3 mouse S41 41122600 ELLGTRGsGGPFQGR X X -PIM2 Pim2 Q9P1W9 human STAT5B 6777 P51692 STAT5B human S731 448751 TyMDQAPsPAVCPQA X -PIM2 Pim2 Q9P1W9 human HK2 3099 P52789 HK2 human T473 28704601 QHRARQktLEHLQLS Hexokinase_1 X X -PIM2 Pim2 Q9P1W9 human Myc 4609 P01106 MYC human S308 10852562 GHskPPHsPLVLkrC Myc_N X -PIM2 Pim2 Q9P1W9 human BAD 12015 Q61337 Bad mouse S155 447863 GRELRRMsDEFEGsF Bcl-2_BAD X 9297 -PIM2 Pim2 Q9P1W9 human PFKFB3 5209 Q16875 PFKFB3 human S478 9318263 tKKPRINsFEEHVAS X X -PIM2 Pim2 Q9P1W9 human p21Cip1 1026 P38936 CDKN1A human T145 447837 QGRkRRQtsMTDFyH X X -PIM2 Pim2 Q9P1W9 human LDH-A 3939 P00338 LDHA human S319 24986816 EEARLkksADtLWGI Ldh_1_C X -PIM2 Pim2 Q9P1W9 human BAD 12015 Q61337 Bad mouse S136 447862 PFRGRsRsAPPNLWA Bcl-2_BAD X 9295; 5286; 4366 -PIM2 Pim2 Q9P1W9 human LDH-A 3939 P00338 LDHA human S161 31882218 PkNrVIGsGCNLDsA X X -PIM2 Pim2 Q9P1W9 human Myc 17869 P01108 Myc mouse S344 2750300 AkRAKLDsGRVLKQI Myc_N X X -PIM2 Pim2 Q9P1W9 human FBPase 14121 Q9QXD6 Fbp1 mouse S144 15501075 FGIyRKKstDEPSEk FBPase X X -PIM2 Pim2 Q9P1W9 human HSF1 3297 Q00613 HSF1 human T120 54414377 ENIkRkVtsVSTLks X X -PIM2 Pim2 Q9P1W9 human BAD 12015 Q61337 Bad mouse S112 447860 ETRsRHssyPAGtEE Bcl-2_BAD X X 9291; 5284; 9296; 5193; 11865; 94223 -PIM2 Pim2 Q9P1W9 human AMPKA1 5562 Q13131 PRKAA1 human S467 7445995 LQLyQVDsRTYLLDF AdenylateSensor X X -PIM2 Pim2 Q9P1W9 human Notch 1 18128 Q01705 Notch1 mouse S2152 3252805 GkkARkPsTkGLACG X -PIM2 Pim2 Q9P1W9 human p21Cip1 1026 P38936 CDKN1A human S146 447836 GRkRRQtsMTDFyHs X -PIM2 Pim2 Q9P1W9 human PSMD2 5708 Q13200 PSMD2 human S361 487471 ENNrFGGsGsQVDsA X X -PIM2 Pim2 Q9P1W9 human IRS1 3667 P35568 IRS1 human S1101 453434 GCRRRHssEtFsStP X -PIM2 Pim2 Q9P1W9 human FOXP3 20371 Q99JB6 Foxp3 mouse S33 25292790 WkTAPkGsELLGTRG X X -PIM2 Pim2 Q9P1W9 human PFKFB3 170768 Q9ESY2 Pfkfb3 mouse S478 9318263 TKKPRINsFEERVAs X X -PIM2 Pim2 Q9P1W9 human FBPase 2203 P09467 FBP1 human S144 15501075 FGIYRKKsTDEPSEK FBPase X X -PIM2 Pim2 Q9P1W9 human PFKFB4 5210 Q16877 PFKFB4 human T140 1879811800 TTRERRAtIFNFGEQ X X -CAMK2A CAMK2A Q9UQM7 human SYN1 24949 P09951 Syn1 rat S566 456356 PQAtRQAsIsGPAPP X -CAMK2A CAMK2A Q9UQM7 human SynGAP 240057 F6SEU4 Syngap1 mouse S1135 451016 PSItKQHsQtPstLN DUF3498 X -CAMK2A CAMK2A Q9UQM7 human PLB 414755 P61012 PLN dog T17 448115 SAIRRAstIEMPQQA Phospholamban X 8496 -CAMK2A CAMK2A Q9UQM7 human AKAP5 9495 P24588 AKAP5 human S92 31878521 LVtRRKRsESsKQQK WSK X -CAMK2A CAMK2A Q9UQM7 human FAM134B 54463 Q9H6L5 RETREG1 human S151 2509195 AQLWRSLsESWEVIN Reticulon X -CAMK2A CAMK2A Q9UQM7 human SCN5A 6331 Q14524 SCN5A human T455 4719534 LTIRGVDtVsRssLE X -CAMK2A CAMK2A Q9UQM7 human Kv4.2 Q63881 Kcnd2 rat S459 2906104 LLSNQLQsSEDEPAF X X -CAMK2A CAMK2A Q9UQM7 human H1R 3269 P35367 HRH1 human T142 453405 YLKYRtKtRASATIL 7tm_1 X -CAMK2A CAMK2A Q9UQM7 human Vimentin 280955 P48616 VIM cow S26 451767 GTASRPSsTRSYVTT Filament_head X -CAMK2A CAMK2A Q9UQM7 human GJA1 24392 P08050 Gja1 rat S306 465459 RNYNkQAsEQNWANy Connexin43 X -CAMK2A CAMK2A Q9UQM7 human SCN5A 6331 Q14524 SCN5A human S484 3799157 KRRKRMssGtEECGE X -CAMK2A CAMK2A Q9UQM7 human CREB3L3 84699 Q68CJ9 CREB3L3 human S395 1880714004 ADTTREEsPGSPGAD X -CAMK2A CAMK2A Q9UQM7 human Ets-2 2114 P15036 ETS2 human S310 477898 LDVQRVPsFEsFEDD Ets1_N_flank X X -CAMK2A CAMK2A Q9UQM7 human ITPKA 3706 P23677 ITPKA human T311 451074 EHAQRAVtKPRYMQW IPK X X -CAMK2A CAMK2A Q9UQM7 human SCN5A 6331 Q14524 SCN5A human S457 4719540 IRGVDtVsRssLEMs X -CAMK2A CAMK2A Q9UQM7 human SMRT 9612 Q9Y618 NCOR2 human S2426 6422852 AsGDRPPsVSSVHsE X X -CAMK2A CAMK2A Q9UQM7 human CAMK2A 25400 P11275 Camk2a rat T310 2869607 ILttMLAtRNFsGGK X -CAMK2A CAMK2A Q9UQM7 human Kir6.2 3767 Q14654 KCNJ11 human T180 450652 QAHRRAEtLIFSKHA X X -CAMK2A CAMK2A Q9UQM7 human GJC1 14615 P28229 Gjc1 mouse S381 22598808 SKSGSNKssIssKsG X -CAMK2A CAMK2A Q9UQM7 human NOX5 iso4 79400 Q96PH1-4 NOX5 human S498 472626 RSVtMRKsQRSsKGS FAD_binding_8 X -CAMK2A CAMK2A Q9UQM7 human SCN8A 6334 Q9UQD0 SCN8A human T642 1869659201 RSVKRNstVDCNGVV Na_trans_cytopl X X -CAMK2A CAMK2A Q9UQM7 human PSD-95 29495 P31016 Dlg4 rat S73 471390 ITLERGNsGLGFSIA PDZ X X -CAMK2A CAMK2A Q9UQM7 human ITGB1 3688 P05556 ITGB1 human T788 448600 PIyksAVttVVNPky Integrin_b_cyt X -CAMK2A CAMK2A Q9UQM7 human TH iso4 7054 P07101-4 TH human S35 448544 AIMVRGQsPRFIGRR TOH_N X -CAMK2A CAMK2A Q9UQM7 human GJA1 24392 P08050 Gja1 rat S372 465460 sRAssRAssRPRPDD X -CAMK2A CAMK2A Q9UQM7 human SPR 29270 P18297 Spr rat S46 469984 LLSARSDsMLRQLKE adh_short X -CAMK2A CAMK2A Q9UQM7 human SCN5A 6331 Q14524 SCN5A human S12 40413902 LLPRGTssFRRFtRE X -CAMK2A CAMK2A Q9UQM7 human Caldesmon 373965 P12957 CALD1 chicken T484 457423 QNGERELtTPKLKsT Caldesmon X -CAMK2A CAMK2A Q9UQM7 human Ets-2 2114 P15036 ETS2 human S313 7113800 QRVPsFEsFEDDCsQ Ets1_N_flank X X -CAMK2A CAMK2A Q9UQM7 human SCN5A 6331 Q14524 SCN5A human S61 40413904 PQLDLQAsKKLPDLY X -CAMK2A CAMK2A Q9UQM7 human DAT 24898 P23977 Slc6a3 rat S13 451138 CsVGPMssVVAPAKE X -CAMK2A CAMK2A Q9UQM7 human Telethonin 8557 O15273 TCAP human S157 448693 GALRRsLsRSMsQEA Telethonin X -CAMK2A CAMK2A Q9UQM7 human sarcolipin 6588 O00631 SLN human T5 459214 ___MGINtRELFLNF Sarcolipin X -CAMK2A CAMK2A Q9UQM7 human CAMK2A 815 Q9UQM7 CAMK2A human T286 447797 sCMHRQEtVDCLKKF X X 12716 -CAMK2A CAMK2A Q9UQM7 human HSL 25330 P15304 Lipe rat S865 448804 ESMRRsVsEAALAQP X 4137 -CAMK2A CAMK2A Q9UQM7 human SCN5A 6331 Q14524 SCN5A human S464 40413909 sRssLEMsPLAPVNs X -CAMK2A CAMK2A Q9UQM7 human CHAT iso3 1103 P28329-3 CHAT human T456 449058 VDNIRSAtPEALAFV Carn_acyltransf X -CAMK2A CAMK2A Q9UQM7 human CAMK2A 815 Q9UQM7 CAMK2A human T305 448802 kLkGAILttMLAtRN X -CAMK2A CAMK2A Q9UQM7 human FosB 14282 P13346 Fosb mouse T149 35530404 PRRPREEtLTPEEEE X -CAMK2A CAMK2A Q9UQM7 human CPEB3 208922 Q7TN99 Cpeb3 mouse S298 25734909 sPLKKPFssNVIAPP X -CAMK2A CAMK2A Q9UQM7 human Ets-1 2113 P14921 ETS1 human S285 449318 QRVPsyDsFDsEDyP Ets1_N_flank X X -CAMK2A CAMK2A Q9UQM7 human SynGAP 240057 F6SEU4 Syngap1 mouse S1162 4792809 VSNMPHLsADIESAH DUF3498 X -CAMK2A CAMK2A Q9UQM7 human SCN5A 6331 Q14524 SCN5A human S571 27281507 PWPLRRtsAQGQPsP Na_trans_cytopl X X -CAMK2A CAMK2A Q9UQM7 human SPR 6697 P35270 SPR human S213 469983 QQLARETsVDPDMRK adh_short X -CAMK2A CAMK2A Q9UQM7 human SCN8A 6334 Q9UQD0 SCN8A human S541 23142148 NRIGRKFsIMNQsLL X -CAMK2A CAMK2A Q9UQM7 human CREB3L3 84699 Q68CJ9 CREB3L3 human S360 1880714000 FAPVRVFsRTLHNDA X -CAMK2A CAMK2A Q9UQM7 human MOR-1 25601 P33535 Oprm1 rat S266 447782 LKsVRMLsGSKEKDR 7tm_1 X -CAMK2A CAMK2A Q9UQM7 human SLC1A3 6507 P43003 SLC1A3 human T26 54247427 QQGVRKRtLLAKkkV X -CAMK2A CAMK2A Q9UQM7 human Securin 9232 O95997 PTTG1 human S31 30977068 LkLGsGPsIkALDGR Securin X -CAMK2A CAMK2A Q9UQM7 human SMAD2 4087 Q15796 SMAD2 human S260 450146 TLsPVNHsLDLQPVT X X -CAMK2A CAMK2A Q9UQM7 human PPP3CA 24674 P63329 Ppp3ca rat S411 2048309 GKMARVFsVLREESE X -CAMK2A CAMK2A Q9UQM7 human TRPC6 22068 Q61143 Trpc6 mouse T487 27839400 RQLFRMKtSCFSWME Ion_trans; TM X -CAMK2A CAMK2A Q9UQM7 human CACNA1C 100101555 P15381 CACB rabbit S1575 467228 VACKRLVsMNMPLNS GPHH X -CAMK2A CAMK2A Q9UQM7 human RYR2 F1PEE8 RYR2 dog S2016 455603 TIRGRLLsLVEKVTY X -CAMK2A CAMK2A Q9UQM7 human TH iso4 7054 P07101-4 TH human S19 448542 KGFRRAVsELDAKQA TOH_N X -CAMK2A CAMK2A Q9UQM7 human p27Kip1 1027 P46527 CDKN1B human S10 447874 NVRVSNGsPsLErMD X -CAMK2A CAMK2A Q9UQM7 human SRF 6722 P11831 SRF human S103 447692 RGLKRsLsEMEIGMV X 4261 -CAMK2A CAMK2A Q9UQM7 human CYLD 1540 Q9NQC7 CYLD human S362 31957307 FyTLNGSsVDSQPQs CYLD_phos_site X X -CAMK2A CAMK2A Q9UQM7 human Caldesmon 373965 P12957 CALD1 chicken S602 457430 CFsPKGSsLKIEERA Caldesmon X -CAMK2A CAMK2A Q9UQM7 human GJA1 24392 P08050 Gja1 rat S325 449992 NRMGQAGstIsNsHA Connexin43 X -CAMK2A CAMK2A Q9UQM7 human ANO1 101772 Q8BHY3 Ano1 mouse S471 50773175 EKSLRKEsRNKETDK Anoctamin X -CAMK2A CAMK2A Q9UQM7 human GJC1 14615 P28229 Gjc1 mouse S384 22598805 GSNKssIssKsGDGK X -CAMK2A CAMK2A Q9UQM7 human TRPV1 83810 O35433 Trpv1 rat S502 450016 YFLQRRPsLKSLFVD Ion_trans X -CAMK2A CAMK2A Q9UQM7 human AKAP5 9495 P24588 AKAP5 human T87 406855301 AsLKRLVtRRKRsES WSK X -CAMK2A CAMK2A Q9UQM7 human RYR2 6262 Q92736 RYR2 human S2814 458801 IsQTSQVsVDAAHGY X -CAMK2A CAMK2A Q9UQM7 human Abi-1 11308 Q8CBW3 Abi1 mouse S88 27115701 SQLRRMEsSINHISQ X -CAMK2A CAMK2A Q9UQM7 human SCN5A 6331 Q14524 SCN5A human S528 451569 KPRssrGsIFtFRRR Na_trans_cytopl X -CAMK2A CAMK2A Q9UQM7 human MCU 215999 Q3UMR5 Mcu mouse S56 27259016 TAHQRPAsWQSVGAA X -CAMK2A CAMK2A Q9UQM7 human GluR1 50592 P19490 Gria1 rat S849 448565 FCLIPQQsINEAIrT X X 75574 -CAMK2A CAMK2A Q9UQM7 human HDAC5 10014 Q9UQL6 HDAC5 human S498 447996 RPLSRtQsSPLPQsP X 3424 -CAMK2A CAMK2A Q9UQM7 human Vimentin 7431 P08670 VIM human S83 451816 GVRLLQDsVdFsLAd Filament_head X 3878; 12569 -CAMK2A CAMK2A Q9UQM7 human PTPRA 19262 P18052 Ptpra mouse S180 447611 QAGsHSNsFRLSNGR X -CAMK2A CAMK2A Q9UQM7 human ICAP1 9270 O14713 ITGB1BP1 human T38 450887 GGLsRsstVAsLDTD ICAP-1_inte_bdg X -CAMK2A CAMK2A Q9UQM7 human eNOS 18127 P70313 Nos3 mouse S1176 447884 TSRIRtQsFsLQERQ X 9571; 9570 -CAMK2A CAMK2A Q9UQM7 human SMARCA2 67155 Q6DIC0 Smarca2 mouse S1382 470425 RPPAEKLsPNPPKLT X -CAMK2A CAMK2A Q9UQM7 human GluR1 14799 P23818 Gria1 mouse S849 448565 FCLIPQQsINEAIRt X X 75574 -CAMK2A CAMK2A Q9UQM7 human SCN5A 6331 Q14524 SCN5A human S497 23142130 GEDRLPKsDsEDGPR X -CAMK2A CAMK2A Q9UQM7 human NOX5 iso4 79400 Q96PH1-4 NOX5 human S475 20612400 WTNRLYEsFKASDPL FAD_binding_8 X X -CAMK2A CAMK2A Q9UQM7 human SERT 6532 P31645 SLC6A4 human S13 31014803 LNSQKQLsACEDGED X -CAMK2A CAMK2A Q9UQM7 human TH 7054 P07101 TH human S71 448545 RFIGRRQsLIEDARK TOH_N X 2791 -CAMK2A CAMK2A Q9UQM7 human sarcolipin Q6SLE7 Sln rat T5 459214 ___MERStQELFINF Sarcolipin X -CAMK2A CAMK2A Q9UQM7 human NLGN1 192167 Q99K10 Nlgn1 mouse T739 30318201 CSPQRTTtNDLTHAP X X -CAMK2A CAMK2A Q9UQM7 human CRMP-2 12934 O08553 Dpysl2 mouse T555 448084 DNIPRRttQRIVAPP X X -CAMK2A CAMK2A Q9UQM7 human SMAD2 4087 Q15796 SMAD2 human S110 450144 SFSEQTRsLDGRLQV MH1 X X -CAMK2A CAMK2A Q9UQM7 human CREB iso1 81646 P15337-1 Creb1 rat S133 448228 EILsRRPsYRkILND pKID X X 9187; 9196; 9198; 4095; 14228; 14001; 39561; 80120; 44864; 54960; 95995 -CAMK2A CAMK2A Q9UQM7 human GJC1 14615 P28229 Gjc1 mouse S326 15499912 AQEQQYGsHEEHLPA X -CAMK2A CAMK2A Q9UQM7 human PXR 8856 O75469 NR1I2 human T290 25682902 LCQLRFNtVFNAETG Hormone_recep X X -CAMK2A CAMK2A Q9UQM7 human FLNA 2316 P21333 FLNA human S2523 448843 VTGPRLVsNHsLHET X -CAMK2A CAMK2A Q9UQM7 human beclin 1 8678 Q14457 BECN1 human S96 472002 MstEsANsFTLIGEA X -CAMK2A CAMK2A Q9UQM7 human RYR2 689560 B0LPN4 Ryr2 rat S2804 458801 IsQTsQVsIDAAHGY X -CAMK2A CAMK2A Q9UQM7 human PPP1R14A 94274 Q96A00 PPP1R14A human S130 454707 GLRQPsPsHDGsLsP PP1_inhibitor X -CAMK2A CAMK2A Q9UQM7 human Kv7.2 iso4 3785 O43526-4 KCNQ2 human S438 481666 QTVRRsPsADQSLED KCNQ_channel X -CAMK2A CAMK2A Q9UQM7 human Ets-1 2113 P14921 ETS1 human S282 449317 NsLQRVPsyDsFDsE Ets1_N_flank X X -CAMK2A CAMK2A Q9UQM7 human NMDAR2B 24410 Q00960 Grin2b rat S1303 450171 NKLRRQHsyDtFVDL NMDAR2_C X 20274; 71335 -CAMK2A CAMK2A Q9UQM7 human GJA1 24392 P08050 Gja1 rat S255 448852 HATTGPLsPskDCGs X -CAMK2A CAMK2A Q9UQM7 human SCN5A 6331 Q14524 SCN5A human S1925 4719576 QRsLKHAsFLFRQQA X -CAMK2A CAMK2A Q9UQM7 human RYR2 20191 E9Q401 Ryr2 mouse S2813 458801 IsQtsQVsIDAAHGY X -CAMK2A CAMK2A Q9UQM7 human SCN5A 6331 Q14524 SCN5A human S510 27281506 PRAMNHLsLTrGLsR Na_trans_cytopl X -CAMK2A CAMK2A Q9UQM7 human Vimentin 81818 P31000 Vim rat S39 451766 TTSTRTYsLGSALRP Filament_head X 13614 -CAMK2A CAMK2A Q9UQM7 human CPEB3 208922 Q7TN99 Cpeb3 mouse T446 4743577 ssGLssPtRCQNGER X -CAMK2A CAMK2A Q9UQM7 human gephyrin 64845 Q03555 Gphn rat S337 481401 NILRAsHsAVDITKV X -CAMK2A CAMK2A Q9UQM7 human CACNA1B 257648 Q02294 Cacna1b rat S2126 467286 SEKQRFYsCDRFGsR X -CAMK2A CAMK2A Q9UQM7 human GFAT 2673 Q06210 GFPT1 human S261 467935 CNLsRVDsttCLFPV X -CAMK2A CAMK2A Q9UQM7 human SCN5A 6331 Q14524 SCN5A human S11 40413901 FLLPRGTssFRRFtR X -CAMK2A CAMK2A Q9UQM7 human SCN5A 6331 Q14524 SCN5A human S577 40413905 tsAQGQPsPGTSAPG Na_trans_cytopl X -CAMK2A CAMK2A Q9UQM7 human CTNNB1 1499 P35222 CTNNB1 human S552 472273 QDtQRRtsMGGtQQQ X 9566; 5651 -CAMK2A CAMK2A Q9UQM7 human CAMK2A 12322 P11798 Camk2a mouse T286 447797 sCMHRQEtVDCLkkF X X 12716 -CAMK2A CAMK2A Q9UQM7 human SAPAP1 iso2 9229 O14490-2 DLGAP1 human S44 456939 CRRMRSGsYIKAMGD X 13638 -CAMK2A CAMK2A Q9UQM7 human nNOS 24598 P29476 Nos1 rat S847 447886 SYKVRFNsVSSYSDS Flavodoxin_1 X -CAMK2A CAMK2A Q9UQM7 human CAMK2A 25400 P11275 Camk2a rat T305 448802 kLkGAILttMLAtRN X -CAMK2A CAMK2A Q9UQM7 human GJA1 24392 P08050 Gja1 rat S365 459207 IVDQRPssRAssRAs X -CAMK2A CAMK2A Q9UQM7 human CAMK2A 25400 P11275 Camk2a rat T306 449596 LkGAILttMLAtRNF X -CAMK2A CAMK2A Q9UQM7 human SCN5A 20271 Q9JJV9 Scn5a mouse S571 27281507 PWPLRRPsTQGQPGF Na_trans_cytopl X -CAMK2A CAMK2A Q9UQM7 human CREB3L3 84699 Q68CJ9 CREB3L3 human T429 1880714002 TLVLRNAtEGLGQVA X -CAMK2A CAMK2A Q9UQM7 human SCN5A 6331 Q14524 SCN5A human S1934 40413914 LFRQQAGsGLsEEDA X -CAMK2A CAMK2A Q9UQM7 human SCN5A 6331 Q14524 SCN5A human S539 4719564 FRRRDLGsEADFADD Na_trans_cytopl X -CAMK2A CAMK2A Q9UQM7 human SYN1 281510 P17599 SYN1 cow S605 450236 AGPTRQAsQAGPMPR X -CAMK2A CAMK2A Q9UQM7 human DRD3 29238 P19020 Drd3 rat S229 482885 RILTRQNsQCISIRP 7tm_1 X -CAMK2A CAMK2A Q9UQM7 human ITGB1 3688 P05556 ITGB1 human T789 447709 IyksAVttVVNPkyE Integrin_b_cyt X -CAMK2A CAMK2A Q9UQM7 human 5-LO 240 P09917 ALOX5 human S272 450169 CsLERQLsLEQEVQQ Lipoxygenase X 3748 -CAMK2A CAMK2A Q9UQM7 human GJA1 24392 P08050 Gja1 rat S364 450183 AIVDQRPssRAssRA X -CAMK2A CAMK2A Q9UQM7 human SCN5A 6331 Q14524 SCN5A human S516 4719558 LsLTrGLsRTsMKPR Na_trans_cytopl X X -CAMK2A CAMK2A Q9UQM7 human GJA1 24392 P08050 Gja1 rat S314 486031 EQNWANysAEQNRMG Connexin43 X -CAMK2A CAMK2A Q9UQM7 human ID1 3397 P41134 ID1 human S36 15411040 GEVVRCLsEQSVAIS X -CAMK2A CAMK2A Q9UQM7 human GABBR1 54393 Q9WV18 Gabbr1 mouse S867 15167000 ITRGEWQsEAQDtMK X -CAMK2A CAMK2A Q9UQM7 human GJA1 24392 P08050 Gja1 rat S328 449993 GQAGstIsNsHAQPF Connexin43 X -CAMK2A CAMK2A Q9UQM7 human SCN5A 6331 Q14524 SCN5A human S460 4719552 VDtVsRssLEMsPLA X -CAMK2A CAMK2A Q9UQM7 human P2X3 81739 P49654 P2rx3 rat T388 33402211 ATVEKQStDSGAySI X -CAMK2A CAMK2A Q9UQM7 human MOR-1 25601 P33535 Oprm1 rat S261 447781 LMILRLKsVRMLsGS 7tm_1 X -CAMK2A CAMK2A Q9UQM7 human H1R 3269 P35367 HRH1 human S398 450937 WKRLRsHsRQyVSGL 7tm_1 X -CAMK2A CAMK2A Q9UQM7 human SynGAP 240057 F6SEU4 Syngap1 mouse S766 4792737 MMRDLNssIDLQSFM DUF3498 X -CAMK2A CAMK2A Q9UQM7 human Ets-1 2113 P14921 ETS1 human S257 449319 DsFEsIEsyDsCDRL Ets1_N_flank X X -CAMK2A CAMK2A Q9UQM7 human Vimentin 280955 P48616 VIM cow S412 451764 EGEESRIsLPLPNFS X -CAMK2A CAMK2A Q9UQM7 human CLCN3 1182 P51790 CLCN3 human S109 451427 ERHRRINsKKKESAW X X -CAMK2A CAMK2A Q9UQM7 human CTNNB1 1499 P35222 CTNNB1 human T332 29614600 VNIMRTytyEkLLWT X -CAMK2A CAMK2A Q9UQM7 human SCN8A 6334 Q9UQD0 SCN8A human S561 1869659200 PFLSRHNsKSSIFSF Na_trans_cytopl X -CAMK2A CAMK2A Q9UQM7 human Vimentin 280955 P48616 VIM cow S66 451765 GVYATRSsAVRLRsG Filament_head X -CAMK2A CAMK2A Q9UQM7 human gp130 3572 P40189 IL6ST human S782 448180 QVFSRsEsTQPLLDS X -CAMK2A CAMK2A Q9UQM7 human HSF1 3297 Q00613 HSF1 human S230 448072 PkYSRQFsLEHVHGS X -CAMK2A CAMK2A Q9UQM7 human HOMER2 26557 Q9QWW1 Homer2 mouse S117 3893303 ARLARDKsQEKTEtS X -CAMK2A CAMK2A Q9UQM7 human Caldesmon 373965 P12957 CALD1 chicken S741 457434 RNLWEKQsVEKPAAS X -CAMK2A CAMK2A Q9UQM7 human NFL 281348 P02548 NEFL cow S58 457405 LSVRRsYsSSSGsLM Filament_head X -CAMK2A CAMK2A Q9UQM7 human CPEB3 208922 Q7TN99 Cpeb3 mouse S419 54003201 YGRRRGRssLFPFED X X -CAMK2A CAMK2A Q9UQM7 human GJA1 24392 P08050 Gja1 rat S330 449994 AGstIsNsHAQPFDF Connexin43 X -CAMK2A CAMK2A Q9UQM7 human myelin P0 539462 P10522 MPZ cow S233 458933 SRSTKAAsEKKTKGL Myelin-PO_C X -CAMK2A CAMK2A Q9UQM7 human PTPRA 19262 P18052 Ptpra mouse S204 447612 PLLARsPstNRKYPP X -CAMK2A CAMK2A Q9UQM7 human RIMS1 84556 Q9JIR4 Rims1 rat S287 455664 KQASRSRsEPPRERK X -CAMK2A CAMK2A Q9UQM7 human CACNA1C 12288 Q01815 Cacna1c mouse S1545 467228 VACKRLVsMNMPLNS GPHH X -CAMK2A CAMK2A Q9UQM7 human NFL 281348 P02548 NEFL cow S67 451023 SSGsLMPsLEsLDLS Filament_head X -CAMK2A CAMK2A Q9UQM7 human IP3R2 P29995 Itpr2 rat S150 26415703 EKNAMRVsLDAAGNE Ins145_P3_rec X -CAMK2A CAMK2A Q9UQM7 human HDAC5 10014 Q9UQL6 HDAC5 human S259 447995 FPLRkTAsEPNLKVR X 3443 -CAMK2A CAMK2A Q9UQM7 human CACNA1C 100101555 P15381 CACB rabbit S1700 4714250 PEIRRAIsGDLtAEE CAC1F_C X -CAMK2A CAMK2A Q9UQM7 human MCU 215999 Q3UMR5 Mcu mouse S91 27259017 VISVRLPsRRERCQF X -CAMK2A CAMK2A Q9UQM7 human CAMK2A iso2 815 Q9UQM7-2 CAMK2A human T286 447797 SCMHRQEtVDCLKKF X -CAMK2A CAMK2A Q9UQM7 human SynGAP 240057 F6SEU4 Syngap1 mouse S752 3573950 PMVLRGPsAEMQGyM DUF3498 X -CAMK2A CAMK2A Q9UQM7 human smMLCK 396445 P11799 MYLK chicken S1762 455821 GMsGRKAsGssPTsP X -CAMK2A CAMK2A Q9UQM7 human SMAD2 4087 Q15796 SMAD2 human S240 450145 SDQQLNQsMDTGsPA X X -CAMK2A CAMK2A Q9UQM7 human Vimentin 280955 P48616 VIM cow S72 449026 SsAVRLRsGVPGVRL Filament_head X -CAMK2A CAMK2A Q9UQM7 human TNNT2 286816 P13789 TNNT2 cow T191 449038 GYIQKAQtERKsGKR Troponin X -CAMK2A CAMK2A Q9UQM7 human MOR-1 25601 P33535 Oprm1 rat T370 447785 sTRVRQNtREHPsTA X -CAMK2A CAMK2A Q9UQM7 human CACNA1C BAA34185.2 CACNA1C guinea pig T1603 7437803 RTALRIKtEGNLEQA Ca_chan_IQ X -CAMK2A CAMK2A Q9UQM7 human SynGAP 240057 F6SEU4 Syngap1 mouse S1222 472605 EYERRLLsQEEQTSk DUF3498 X -CAMK2A CAMK2A Q9UQM7 human SynGAP 240057 F6SEU4 Syngap1 mouse S1111 481549 QsLskEGsIGGsGGs DUF3498 X -CAMK2A CAMK2A Q9UQM7 human SCN8A 6334 Q9UQD0 SCN8A human S641 1869659202 RRSVKRNstVDCNGV Na_trans_cytopl X -CAMK2A CAMK2A Q9UQM7 human SCN5A 6331 Q14524 SCN5A human S483 3799151 sKRRKRMssGtEECG X -CAMK2A CAMK2A Q9UQM7 human SynGAP 240057 F6SEU4 Syngap1 mouse S1107 1867842100 RPRQQsLskEGsIGG DUF3498 X -CAMK2A CAMK2A Q9UQM7 human MECP2 29386 Q00566 Mecp2 rat S421 470075 EKMPRAGsLESDGCP X -CAMK2A CAMK2A Q9UQM7 human KCND1 3750 Q9NSA2 KCND1 human S555 4714921 TASVSRGsMQELDML X -CAMK2A CAMK2A Q9UQM7 human FBX43 286151 Q4G163 FBXO43 human T234 13419500 FSQQKTStIDDSKDD X -CAMK2A CAMK2A Q9UQM7 human CAMK2A 815 Q9UQM7 CAMK2A human T306 449596 LkGAILttMLAtRNF X -CAMK2A CAMK2A Q9UQM7 human RRAD 6236 P55042 RRAD human S273 457396 AGTRRREsLGKKAKR X -CAMK2A CAMK2A Q9UQM7 human phosducin 20028 Q9QW08 Pdc mouse S54 454888 KEILRQMsSPQSRDD Phosducin X -CAMK2A CAMK2A Q9UQM7 human Caldesmon 373965 P12957 CALD1 chicken S59 1868253000 QKEEGDVsGEVTEKS Caldesmon X -CAMK2A CAMK2A Q9UQM7 human SYN1 20964 O88935 Syn1 mouse S605 450236 AGPtRQAsQAGPGPr X 88246 -CAMK2A CAMK2A Q9UQM7 human FosB 14282 P13346 Fosb mouse T180 35530403 RNRRRELtDRLQAET bZIP_1 X -CAMK2A CAMK2A Q9UQM7 human GJA1 24392 P08050 Gja1 rat S373 459209 RAssRAssRPRPDDL X -CAMK2A CAMK2A Q9UQM7 human RIMS1 84556 Q9JIR4 Rims1 rat S241 455663 RLQERSRsQTPLSTA X -CAMK2A CAMK2A Q9UQM7 human KIF3A 16568 P28741 Kif3a mouse S698 50247605 KPEtVIDsLLQ____ X -CAMK2A CAMK2A Q9UQM7 human KIF3A 16568 P28741 Kif3a mouse T694 31906433 KRsAKPEtVIDsLLQ X -CAMK2A CAMK2A Q9UQM7 human TH iso4 7054 P07101-4 TH human S44 448545 RFIGRRQsLIEDARK TOH_N X 2791 -CAMK2A CAMK2A Q9UQM7 human PANX1 315435 P60570 Panx1 rat S394 14577460 TKGEDQGsQRMDFKD X -CAMK2A CAMK2A Q9UQM7 human RCHY1 25898 Q96PM5 RCHY1 human T154 483981 ICLEDIHtsRVVAHV zf-RING_2 X X -CAMK2A CAMK2A Q9UQM7 human CACNA1C iso4 P15381-4 CACNA1C rabbit S1570 467228 VACKRLVsMNMPLNS GPHH X -CAMK2A CAMK2A Q9UQM7 human DLG1 25252 Q62696 Dlg1 rat S39 451614 SSIERVIsIFQSNLF L27_1 X -CAMK2A CAMK2A Q9UQM7 human CACNA1C iso4 P15381-4 CACNA1C rabbit S1512 460572 DYLTRDWsILGPHHL Ion_trans X -CAMK2A CAMK2A Q9UQM7 human CACNA1B 257648 Q02294 Cacna1b rat S784 455282 RLQNLRAsCEALYSE X -CAMK2A CAMK2A Q9UQM7 human STMN1 3925 P16949 STMN1 human S16 448554 kELEKrAsGQAFELI Stathmin X 3353 -CAMK2A CAMK2A Q9UQM7 human GJA1 24392 P08050 Gja1 rat S257 465456 TTGPLsPskDCGsPk X -CAMK2A CAMK2A Q9UQM7 human TPH2 216343 Q8CGV2 Tph2 mouse S19 470085 YWARRGLsLDSAVPE X -CAMK2A CAMK2A Q9UQM7 human GJC1 14615 P28229 Gjc1 mouse S382 22598807 KSGSNKssIssKsGD X -CAMK2A CAMK2A Q9UQM7 human mGluR1 24414 P23385 Grm1 rat T871 4713375 KLPCRSNtFLNIFRR X -CAMK2A CAMK2A Q9UQM7 human Securin 9232 O95997 PTTG1 human S89 31879178 KQKQPsFsAKKMTEK Securin X -CAMK2A CAMK2A Q9UQM7 human SCN5A 6331 Q14524 SCN5A human T17 40413900 TssFRRFtREsLAAI X -CAMK2A CAMK2A Q9UQM7 human CACNA1C 12288 Q01815 Cacna1c mouse S1487 460572 DYLTRDWsILGPHHL Ion_trans X -CAMK2A CAMK2A Q9UQM7 human HOMER2 26557 Q9QWW1 Homer2 mouse S216 51633301 EQWKRQFsICRDEND X -CAMK2A CAMK2A Q9UQM7 human TH 7054 P07101 TH human S19 448542 KGFRRAVsELDAKQA TOH_N X X -CAMK2A CAMK2A Q9UQM7 human SCN5A 6331 Q14524 SCN5A human S1920 40413910 RRHLLQRsLKHAsFL X -CAMK2A CAMK2A Q9UQM7 human SCN5A 6331 Q14524 SCN5A human S1885 40413913 KFMAANPsKISYEPI X -CAMK2A CAMK2A Q9UQM7 human NMDAR2A 2903 Q12879 GRIN2A human S1459 481117 RVYKKMPsIESDV__ NMDAR2_C X X -CAMK2A CAMK2A Q9UQM7 human CYLD 1540 Q9NQC7 CYLD human S418 4745557 TTENRFHsLPFsLtK CYLD_phos_site X X 4500 -CAMK2A CAMK2A Q9UQM7 human MYH9 25745 Q62812 Myh9 rat T1940 452194 RRIVRKGtGDCsDEE X -CAMK2A CAMK2A Q9UQM7 human SMRT 9612 Q9Y618 NCOR2 human S2453 4785906 VWEDRPssAGstPFP X -CAMK2A CAMK2A Q9UQM7 human MOR-1 4988 P35372 OPRM1 human S268 447782 LKsVRMLsGsKEKDR 7tm_1 X -CAMK2A CAMK2A Q9UQM7 human NOX5 iso4 79400 Q96PH1-4 NOX5 human S659 20612404 ANKEKKDsITGLQTR NAD_binding_6 X -CAMK2A CAMK2A Q9UQM7 human DLG1 25252 Q62696 Dlg1 rat S232 451615 ITLERGNsGLGFSIA PDZ X -CAMK2A CAMK2A Q9UQM7 human KIF3A 11127 Q9Y496 KIF3A human S687 454304 KTGRRKRsAkPEtVI X -CAMK2A CAMK2A Q9UQM7 human CPEB3 208922 Q7TN99 Cpeb3 mouse S420 54003200 GRRRGRssLFPFEDA X X -CAMK2A CAMK2A Q9UQM7 human Caldesmon 373965 P12957 CALD1 chicken S26 457417 RLEAERLsyQRNDDD X -CAMK2A CAMK2A Q9UQM7 human GluR2 14800 P23819 Gria2 mouse S880 448351 yNVyGIEsVKI____ X -CAMK2A CAMK2A Q9UQM7 human SCN5A 6331 Q14524 SCN5A human S667 25752820 QRALsAVsVLtsALE Na_trans_cytopl X -CAMK2A CAMK2A Q9UQM7 human PLB 18821 P61014 Pln mouse T17 448115 SAIRRAstIEMPQQA Phospholamban X 8496 -CAMK2A CAMK2A Q9UQM7 human NSDDR 747 Q9Y4D2 DAGLA human S782 27807805 APLATMEsLSDTESL X -CAMK2A CAMK2A Q9UQM7 human SCN5A 6331 Q14524 SCN5A human S20 40413903 FRRFtREsLAAIEKR X -CAMK2A CAMK2A Q9UQM7 human CARD11 84433 Q9BXL7 CARD11 human S116 466431 KEPTRRFstIVVEEG X -CAMK2A CAMK2A Q9UQM7 human KIF17 16559 Q99PW8 Kif17 mouse S1029 1720900 SKAKRKKsKNSFGGE X -CAMK2A CAMK2A Q9UQM7 human CAMK2A 25400 P11275 Camk2a rat S314 451708 MLAtRNFsGGKSGGN X -CAMK2A CAMK2A Q9UQM7 human RYR2 F1PEE8 RYR2 dog S2799 458801 IsQTSQVsVDAAHGY X -CAMK2A CAMK2A Q9UQM7 human NFL 281348 P02548 NEFL cow S70 466427 sLMPsLEsLDLSQVA Filament_head X -CAMK2A CAMK2A Q9UQM7 human SCN5A 6331 Q14524 SCN5A human S1937 40413906 QQAGsGLsEEDAPER X -CAMK2A CAMK2A Q9UQM7 human NMDAR2A 14811 P35436 Grin2a mouse S1459 481117 RVYKKMPsIEsDV__ NMDAR2_C X X -CAMK2A CAMK2A Q9UQM7 human SLC1A3 6507 P43003 SLC1A3 human T37 60189903 KkkVQNItkEDVKSY X -CAMK2A CAMK2A Q9UQM7 human SynGAP 240057 F6SEU4 Syngap1 mouse S1105 8098868 PARPRQQsLskEGsI DUF3498 X -CAMK2A CAMK2A Q9UQM7 human PLCB3 5331 Q01970 PLCB3 human S537 448450 PSLEPQKsLGDEGLN X X 2481; 29021 -CAMK2A CAMK2A Q9UQM7 human SynGAP 240057 F6SEU4 Syngap1 mouse S780 451015 MARGLNSsMDMARLP DUF3498 X -CAMK2A CAMK2A Q9UQM7 human CACNA1B 257648 Q02294 Cacna1b rat S896 455283 ERARPRRsHsKEAPG X -CAMK2A CAMK2A Q9UQM7 human PPP2R2B iso2 5521 Q00005-2 PPP2R2B human S22 25554902 PNTILsssCHTEADI X -CAMK2A CAMK2A Q9UQM7 human GJA1 24392 P08050 Gja1 rat S296 465457 VTGDRNNssCRNYNk Connexin43 X -CAMK2A CAMK2A Q9UQM7 human SPR 29270 P18297 Spr rat S214 469983 QQLARETsMDPELRS adh_short X -CAMK2A CAMK2A Q9UQM7 human RCHY1 25898 Q96PM5 RCHY1 human S155 483982 CLEDIHtsRVVAHVL zf-RING_2 X X -CAMK2A CAMK2A Q9UQM7 human rabphilin 3A 171039 P47709 Rph3a rat S274 455801 QGLRRANsVQASRPA X -CAMK2A CAMK2A Q9UQM7 human GluR4 29629 P19493 Gria4 rat S862 448810 TRNKARLsITGSVGE X -CAMK2A CAMK2A Q9UQM7 human SCN5A 6331 Q14524 SCN5A human S1865 40413915 TKRVLGEsGEMDALK X -CAMK2A CAMK2A Q9UQM7 human gephyrin 64845 Q03555 Gphn rat S335 18910590 KENILRAsHsAVDIT X -CAMK2A CAMK2A Q9UQM7 human LRP4 83469 Q9QYP1 Lrp4 rat S1887 465668 TTPERRGsLPDTGWK X -CAMK2A CAMK2A Q9UQM7 human SCN5A 6331 Q14524 SCN5A human S2007 34355964 DLADFPPsPDRDRES X -CAMK2A CAMK2A Q9UQM7 human CACNA1S 100009585 P07293 CACNA1S rabbit S1575 6064601 PEIRRTIsGDLtAEE X -CAMK2A CAMK2A Q9UQM7 human PLB 414755 P61012 PLN dog S16 448114 RSAIRRAstIEMPQQ Phospholamban X 8496 -CAMK2A CAMK2A Q9UQM7 human Vimentin 280955 P48616 VIM cow S39 451766 TTSTRTYsLGSALRP Filament_head X -CAMK2A CAMK2A Q9UQM7 human SynGAP 192117 Q9QUH6 Syngap1 rat S1138 451016 PSITkQHsQTPSTLN DUF3498 X -CAMK2A CAMK2A Q9UQM7 human sarcolipin 66402 Q9CQD6 Sln mouse T5 459214 ___MERStQELFINF Sarcolipin X -CAMK2A CAMK2A Q9UQM7 human Kv4.2 Q63881 Kcnd2 rat S438 2906103 ARIRAAksGSANAYM X X -CAMK2A CAMK2A Q9UQM7 human CYLD 1540 Q9NQC7 CYLD human S772 31957308 LFKkIFPsLELNITD UCH X X -CAMK2A CAMK2A Q9UQM7 human CD44 960 P16070 CD44 human S706 450988 LNGEAsksQEMVHLV X X -CAMK2A CAMK2A Q9UQM7 human GJC1 14615 P28229 Gjc1 mouse S385 22598809 SNKssIssKsGDGKT X -CAMK2A CAMK2A Q9UQM7 human NOX5 iso4 79400 Q96PH1-4 NOX5 human S502 20612402 MRKsQRSsKGSEILL FAD_binding_8 X -CAMK2A CAMK2A Q9UQM7 human GJC1 14615 P28229 Gjc1 mouse T337 22598811 HLPADLEtLQREIRM X -CAMK2A CAMK2A Q9UQM7 human VEGFR2 16542 P35918 Kdr mouse S982 10940352 FVEEKSLsDVEEEEA PK_Tyr_Ser-Thr X -CAMK2A CAMK2A Q9UQM7 human CREB 12912 Q01147 Creb1 mouse S119 448228 EILsRRPsyRkILND pKID X 9187; 9196; 9198; 4095; 14228; 14001; 39561; 80120; 44864; 54960; 95995 -CAMK2A CAMK2A Q9UQM7 human HDAC5 84580 F1LM64 Hdac5 rat S322 447996 RPLSRTQsSPLPQSP X -CAMK2A CAMK2A Q9UQM7 human separase 9700 Q14674 ESPL1 human S1501 447668 TDNWRKMsFEILRGs X -CAMK2A CAMK2A Q9UQM7 human NETO2 307757 C6K2K4 Neto2 rat S409 4752528 SLREKEIsADLADLS X X -CAMK2A CAMK2A Q9UQM7 human CACNA1H 8912 O95180 CACNA1H human S1198 22648004 tPLRRAEsLDPRPLR X -CAMK2A CAMK2A Q9UQM7 human TH iso3 7054 P07101-3 TH human S40 448545 RFIGRRQsLIEDARK TOH_N X 2791 -CAMK2A CAMK2A Q9UQM7 human LRP4 83469 Q9QYP1 Lrp4 rat S1900 465667 WKHERKLsSESQV__ X -CAMK2A CAMK2A Q9UQM7 human PSD-95 1742 P78352 DLG4 human S73 471390 ITLERGNsGLGFsIA PDZ X -CAMK2A CAMK2A Q9UQM7 human CPEB3 208922 Q7TN99 Cpeb3 mouse S299 25734913 PLKKPFssNVIAPPK X -CAMK2A CAMK2A Q9UQM7 human SCN5A 6331 Q14524 SCN5A human S1503 9993604 NAMKKLGsKKPQKPI X -CAMK2A CAMK2A Q9UQM7 human beclin 1 8678 Q14457 BECN1 human S93 5473540 ARMMstEsANsFTLI X 14717 -CAMK2A CAMK2A Q9UQM7 human SCN5A 6331 Q14524 SCN5A human S471 10404937 sPLAPVNsHERRsKR X -CAMK2A CAMK2A Q9UQM7 human BRSK1 499073 B2DD29 Brsk1 rat T189 456027 VGDSLLEtSCGSPHY Pkinase X X -CAMK2A CAMK2A Q9UQM7 human Securin 9232 O95997 PTTG1 human T66 33663901 AtRkALGtVNRATEK Securin X -CAMK2A CAMK2A Q9UQM7 human GJC1 14615 P28229 Gjc1 mouse S387 22598806 KssIssKsGDGKTsV X -CAMK2A CAMK2A Q9UQM7 human H1R 3269 P35367 HRH1 human S396 453404 FTWKRLRsHsRQyVS 7tm_1 X -CAMK2A CAMK2A Q9UQM7 human Ets-2 2114 P15036 ETS2 human S246 7113802 FPkSRLSsVsVTYCS Ets1_N_flank X -CAMK2A CAMK2A Q9UQM7 human beclin 1 8678 Q14457 BECN1 human S90 472001 IPPARMMstEsANsF X X 29362; 86455 -CAMK2A CAMK2A Q9UQM7 human SPR 29270 P18297 Spr rat S196 469985 EPSVRVLsYAPGPLD adh_short X -CAMK2A CAMK2A Q9UQM7 human CACNA1C 100101555 P15381 CACB rabbit S1517 460572 DYLTRDWsILGPHHL Ion_trans X -CAMK2A CAMK2A Q9UQM7 human SCN5A 6331 Q14524 SCN5A human S1998 40413911 RGSDYSHsEDLADFP X -CAMK2A CAMK2A Q9UQM7 human Caldesmon 373965 P12957 CALD1 chicken S73 457422 SEVNAQNsVAEEETK Caldesmon X -CAMK2A CAMK2A Q9UQM7 human SCN5A 6331 Q14524 SCN5A human S1003 40413908 AAQGQLPsCIATPYS Na_trans_assoc X -CAMK2A CAMK2A Q9UQM7 human RYR2 689560 B0LPN4 Ryr2 rat S2798 448848 yNRTRRIsQTsQVsI X -CAMK2A CAMK2A Q9UQM7 human CACNA1C 100101555 P15381 CACB rabbit S439 460571 GVLSGEFsKEREKAK Ion_trans X -CAMK2A CAMK2A Q9UQM7 human Caldesmon 373965 P12957 CALD1 chicken S635 457432 AVVsKIDsRLEQyTs Caldesmon X -CAMK2A CAMK2A Q9UQM7 human TRPV1 83810 O35433 Trpv1 rat T704 487542 WKLQRAItILDTEKS X -CAMK2A CAMK2A Q9UQM7 human CTNNB1 1499 P35222 CTNNB1 human T472 3653236 ICALRHLtsRHQEAE Arm X -CAMK2A CAMK2A Q9UQM7 human NMDAR2B 2904 Q13224 GRIN2B human S1303 450171 NKLRRQHsyDtFVDL NMDAR2_C X 20274; 71335 -CAMK2A CAMK2A Q9UQM7 human Tau 281296 P29172 MAPT cow S423 454127 SNVSSTGsIDMVDSP X 15013; 61160 -CAMK2A CAMK2A Q9UQM7 human myelin P0 539462 P10522 MPZ cow S210 458930 HKTAKDAsKRGRQTP Myelin-PO_C X -CAMK2A CAMK2A Q9UQM7 human WEE1B 381759 Q66JT0 Wee2 mouse S15 456697 QGLNKKLsFSFCEED X X -CAMK2A CAMK2A Q9UQM7 human GluR1 2890 P42261 GRIA1 human S567 17934900 FSPYEWHsEEFEEGR Lig_chan X -CAMK2A CAMK2A Q9UQM7 human GLO1 2739 Q04760 GLO1 human T107 7106304 ELTHNWGtEDDETQS Glyoxalase X -CAMK2A CAMK2A Q9UQM7 human RYR2 6262 Q92736 RYR2 human S2808 448848 YNRTRRIsQTSQVsV X -CAMK2A CAMK2A Q9UQM7 human SNCA 6622 P37840 SNCA human S129 448278 NEAyEMPsEEGyQDy Synuclein X 23706; 87281 -CAMK2A CAMK2A Q9UQM7 human Tau iso8 4137 P10636-8 MAPT human S262 447930 NVKskIGstENLkHQ Tubulin-binding X -CAMK2A CAMK2A Q9UQM7 human Tau iso8 4137 P10636-8 MAPT human S416 454127 sNVsstGsIDMVDsP X 15013; 61160 -CAMK2A CAMK2A Q9UQM7 human H1R 3269 P35367 HRH1 human T140 453406 LRYLKYRtKtRASAT 7tm_1 X -CAMK2A CAMK2A Q9UQM7 human CREB iso1 81646 P15337-1 Creb1 rat S142 448547 RkILNDLssDAPGVP pKID X -CAMK2A CAMK2A Q9UQM7 human mAChR M4 25111 P08485 Chrm4 rat T145 14699600 TYPARRTtKMAGLMI 7tm_1 X X -CAMK2A CAMK2A Q9UQM7 human TH iso3 7054 P07101-3 TH human S19 448542 KGFRRAVsELDAKQA TOH_N X -CAMK2A CAMK2A Q9UQM7 human CDK5R1 116671 P61810 Cdk5r1 rat S91 12607404 ENLKKSLsCANLSTF X -CAMK2A CAMK2A Q9UQM7 human smMLCK 396445 P11799 MYLK chicken S1749 466361 RAIGRLSsMAMISGM X -CAMK2A CAMK2A Q9UQM7 human GJA1 24392 P08050 Gja1 rat S369 459208 RPssRAssRAssRPR X -CAMK2A CAMK2A Q9UQM7 human FosB 14282 P13346 Fosb mouse S27 465535 SAESQYLsSVDSFGS X -CAMK2A CAMK2A Q9UQM7 human NSDDR 747 Q9Y4D2 DAGLA human S808 27807806 RSIRGsPsLHAVLER X -CAMK2A CAMK2A Q9UQM7 human SPTBN4 57731 Q9H254 SPTBN4 human S2254 481487 RRPERQEsVDQSEEA X -CAMK2A CAMK2A Q9UQM7 human PPP2R2B iso2 5521 Q00005-2 PPP2R2B human S20 25554903 RPPNTILsssCHTEA X -CAMK2A CAMK2A Q9UQM7 human RPT6 81827 P62198 Psmc5 rat S120 483970 RVALRNDsYTLHKIL Prot_ATP_ID_OB X -CAMK2A CAMK2A Q9UQM7 human NOX5 iso4 79400 Q96PH1-4 NOX5 human T494 472625 KRLsRSVtMRKsQRS FAD_binding_8 X -CAMK2A CAMK2A Q9UQM7 human SCN5A 6331 Q14524 SCN5A human T570 40413907 VPWPLRRtsAQGQPs Na_trans_cytopl X -CAMK2A CAMK2A Q9UQM7 human CPEB3 208922 Q7TN99 Cpeb3 mouse S291 25288000 PsPLNPIsPLKKPFs X -CAMK2A CAMK2A Q9UQM7 human PEA-15 100736554 Q9Z297 Pea15 hamster S116 450281 KDIIRQPsEEEIIKL X -CAMK2A CAMK2A Q9UQM7 human GluR1 50592 P19490 Gria1 rat S645 471090 LTVERMVsPIESAED Lig_chan X -CAMK2A CAMK2A Q9UQM7 human GJA1 24392 P08050 Gja1 rat S297 465458 TGDRNNssCRNYNkQ Connexin43 X -CAMK2A CAMK2A Q9UQM7 human FAK 14083 P34152 Ptk2 mouse S843 447963 DVRLsRGsIDREDGS X -CAMK2A CAMK2A Q9UQM7 human CPEB3 208922 Q7TN99 Cpeb3 mouse S443 2658904 QALssGLssPtRCQN X -CAMK2A CAMK2A Q9UQM7 human GJA1 24392 P08050 Gja1 rat S244 17743400 KDRVKGRsDPyHATT X -CAMK2A CAMK2A Q9UQM7 human Kir6.2 3767 Q14654 KCNJ11 human T224 453090 MQVVRKTtSPEGEVV IRK_C X X -CAMK2A CAMK2A Q9UQM7 human SCN5A 6331 Q14524 SCN5A human S664 27281501 GARQRALsAVsVLts Na_trans_cytopl X -CAMK2A CAMK2A Q9UQM7 human GJC1 14615 P28229 Gjc1 mouse S393 22598810 KsGDGKTsVWI____ X -CAMK2A CAMK2A Q9UQM7 human SCN5A 6331 Q14524 SCN5A human S42 27281503 GSTTLQEsREGLPEE X -CAMK2A CAMK2A Q9UQM7 human SCN5A 6331 Q14524 SCN5A human S499 40413912 DRLPKsDsEDGPRAM X -CAMK2A CAMK2A Q9UQM7 human Securin 9232 O95997 PTTG1 human S87 3845109 PLKQKQPsFsAKKMT Securin X -CAMK2A CAMK2A Q9UQM7 human PLB 5350 P26678 PLN human T17 448115 SAIRRAstIEMPQQA Phospholamban X 8496 -CAMK2A CAMK2A Q9UQM7 human Caldesmon 373965 P12957 CALD1 chicken S490 457429 LtTPKLKsTENAFGR Caldesmon X -CAMK2A CAMK2A Q9UQM7 human RYR2 20191 E9Q401 Ryr2 mouse S2807 448848 YNRTRRIsQtsQVsI X -CAMK2A CAMK2A Q9UQM7 human Telethonin 8557 O15273 TCAP human S161 3893741 RsLsRSMsQEAQRG_ Telethonin X -CAMK2A CAMK2A Q9UQM7 human PPP2R2B iso2 5521 Q00005-2 PPP2R2B human S21 25554901 PPNTILsssCHTEAD X -CAMK2A CAMK2A Q9UQM7 human HDAC5 84580 F1LM64 Hdac5 rat S83 447995 FPLRKTAsEPNLKVR X -CAMK2A CAMK2A Q9UQM7 human Ets-1 2113 P14921 ETS1 human S251 449316 GkLGGQDsFEsIEsy Ets1_N_flank X X -CSNK2A1 CK2A1 P68400 human RIGI 23586 O95786 RIGI human S854 17484202 HPKPkQFssFEkRAK RIG-I_C-RD X X -CSNK2A1 CK2A1 P68400 human PAK1 5058 Q13153 PAK1 human S223 454121 DVAtsPIsPtENNtt X X -CSNK2A1 CK2A1 P68400 human HMGA2 15364 P52927 Hmga2 mouse S101 469757 QETEEtssQEsAEED X -CSNK2A1 CK2A1 P68400 human ataxin-3 110616 Q9CVD2 Atxn3 mouse S29 13421402 LLQGEYFsPVELSSI Josephin X X -CSNK2A1 CK2A1 P68400 human DDIT3 1649 P35638 DDIT3 human S31 455504 DLQEVLssDENGGTY X -CSNK2A1 CK2A1 P68400 human CD10 4311 P08473 MME human S6 3850156 __MGKsEsQMDItDI X X -CSNK2A1 CK2A1 P68400 human PTEN 5728 P60484 PTEN human S380 448313 EPDHyRYsDttDsDP X 9551; 9554; 9549; 7960 -CSNK2A1 CK2A1 P68400 human MSK1 9252 O75582 RPS6KA5 human S760 12159002 TETRssssESSHSsS X -CSNK2A1 CK2A1 P68400 human PPP1R2 5504 P41236 PPP1R2 human S87 449054 GDDEDACsDtEAtEA IPP-2 X -CSNK2A1 CK2A1 P68400 human CFTR 12638 P26361 Cftr mouse S670 3333405 TETLRRFsVDDSSAP CFTR_R X -CSNK2A1 CK2A1 P68400 human caveolin-2 858 P51636 CAV2 human S36 469561 DPEKFADsDQDRDPH Caveolin X X -CSNK2A1 CK2A1 P68400 human SPTBN1 6711 Q01082 SPTBN1 human S2110 471398 PEPstKVsEEAEsQQ X -CSNK2A1 CK2A1 P68400 human NHE3 100009430 P26432 NHE-3 rabbit S554 450899 TEGERRGsLAFIRSP X -CSNK2A1 CK2A1 P68400 human IRS1 25467 P35570 Irs1 rat S612 447562 DDGyMPMsPGVAPVP X 3193; 2386; 3203 -CSNK2A1 CK2A1 P68400 human Sialoprotein-2 281233 Q28862 IBSP cow S86 457544 EEEEEETsNEEGNNG BSP_II X -CSNK2A1 CK2A1 P68400 human PER2 18627 O54943 Per2 mouse S53 9439800 TGRDSQGsDCDDNGK X X -CSNK2A1 CK2A1 P68400 human 14-3-3 theta 10971 P27348 YWHAQ human S232 456053 LTLWtsDsAGEECDA X -CSNK2A1 CK2A1 P68400 human FAF1 11124 Q9UNN5 FAF1 human S291 450287 DVHMVsDsDGDDFED X -CSNK2A1 CK2A1 P68400 human MYH10 4628 P35580 MYH10 human S1956 465600 EGAsLELsDDDtEsK X -CSNK2A1 CK2A1 P68400 human CREB iso1 81646 P15337-1 Creb1 rat S111 451808 TIAEsEDsQEsVDsV X -CSNK2A1 CK2A1 P68400 human ZC3H8 84524 Q8N5P1 ZC3H8 human T32 3206328 RIDDEIDtEVEETQE X -CSNK2A1 CK2A1 P68400 human CDC27 996 P30260 CDC27 human S154 18258506 FLWSPFEsLCEIGEK X -CSNK2A1 CK2A1 P68400 human occludin 100506658 Q16625 OCLN human T404 471472 HyEtDyttGGEsCDE X X -CSNK2A1 CK2A1 P68400 human Calmodulin 24242 P0DP29 Calm3 rat S102 448706 kDGNGyIsAAELRHV EF-hand_7 X X -CSNK2A1 CK2A1 P68400 human Sialoprotein-2 281233 Q28862 IBSP cow S106 467257 DENEDEEsEAENTTL BSP_II X -CSNK2A1 CK2A1 P68400 human TDP-43 23435 Q13148 TARDBP human S379 3084615 NSYsGsNsGAAIGWG X -CSNK2A1 CK2A1 P68400 human NCAM-L1 3897 P32004 L1CAM human S1181 465573 GEyRSLEsDNEEKAF Bravo_FIGEY X -CSNK2A1 CK2A1 P68400 human XRCC1 7515 P18887 XRCC1 human T488 451452 GAEDsGDtEDELRRV X X -CSNK2A1 CK2A1 P68400 human GRB14 2888 Q14449 GRB14 human S362 31834912 QGRsGCSsQSIsPMR X -CSNK2A1 CK2A1 P68400 human CBX1 10951 P83916 CBX1 human T51 2753801 GFSDEDNtWEPEENL Chromo X X -CSNK2A1 CK2A1 P68400 human RP1 10982 Q15555 MAPRE2 human S236 23140241 SSGSASksDkDLETQ X X -CSNK2A1 CK2A1 P68400 human SQSTM1 8878 Q13501 SQSTM1 human S403 22264800 ESLSQMLsMGFsDEG UBA_5 X X 39786 -CSNK2A1 CK2A1 P68400 human ER-alpha 2099 P03372 ESR1 human S282 6048401 EGrGEVGsAGDMRAA X X -CSNK2A1 CK2A1 P68400 human ATF-4 468 P18848 ATF4 human S184 1876136802 SFSLELGsEVDITEG X -CSNK2A1 CK2A1 P68400 human treacle 6949 Q13428 TCOF1 human T210 35530406 TSSSSDEtDVEGKPS X X -CSNK2A1 CK2A1 P68400 human ECE1 iso3 1889 P42892-3 ECE1 human S20 3053606 EDLVDsLsEGDAYPN X X -CSNK2A1 CK2A1 P68400 human XRCC1 7515 P18887 XRCC1 human S421 3181474 EAsHsGGsGDEAPKL X -CSNK2A1 CK2A1 P68400 human RPS5 20103 P97461 Rps5 mouse S34 9819907 DVQINDIsLQDYIAV X -CSNK2A1 CK2A1 P68400 human PACS2 23241 Q86VP3 PACS2 human S207 1884003500 EEEYESFssEQEAsD X X -CSNK2A1 CK2A1 P68400 human VTN 7448 P04004 VTN human T76 451404 tMPEDEytVYDDGEE X -CSNK2A1 CK2A1 P68400 human DARPP-32 360616 Q6J4I0 Ppp1r1b rat S45 465607 LFRVSEHssPEEESS DARPP-32 X -CSNK2A1 CK2A1 P68400 human N-WASP 682507 O08816 Wasl rat S481 3149547 RSKAIHssDEDEDDD X X -CSNK2A1 CK2A1 P68400 human RNPS1 10921 Q15287 RNPS1 human S53 455347 KGATKEssEKDRGRD X X -CSNK2A1 CK2A1 P68400 human CTNNA1 1495 P35221 CTNNA1 human S641 449139 tPEELDDsDFEtEDF Vinculin X X -CSNK2A1 CK2A1 P68400 human SMRT 9612 Q9Y618 NCOR2 human S2511 465590 CSQYETLsDsE____ X -CSNK2A1 CK2A1 P68400 human YY1 7528 P25490 YY1 human S118 460025 EVVGGDDsDGLRAED X X -CSNK2A1 CK2A1 P68400 human WASP 7454 P42768 WAS human S483 449294 KRSRAIHssDEGEDQ X X -CSNK2A1 CK2A1 P68400 human ARC 8996 O60936 NOL3 human T149 448618 SEAVQSGtPEEPEPE X -CSNK2A1 CK2A1 P68400 human DNAJB2 3300 P25686 DNAJB2 human S247 34505486 PASCPLDsDLsEDED X -CSNK2A1 CK2A1 P68400 human STAT1 6772 P42224 STAT1 human S727 447753 TDNLLPMsPEEFDEV STAT1_TAZ2bind X 9177; 8826; 62390 -CSNK2A1 CK2A1 P68400 human LASS5 91012 Q8N5B7 CERS5 human S356 18260888 RsDVEsssEEEDVTT X -CSNK2A1 CK2A1 P68400 human ECE1 iso3 1889 P42892-3 ECE1 human S18 3053605 DEEDLVDsLsEGDAY X X -CSNK2A1 CK2A1 P68400 human IRS1 25467 P35570 Irs1 rat T502 449932 MGTsPALtGDEAAGA X -CSNK2A1 CK2A1 P68400 human CACNA1C 100101555 P15381 CACB rabbit T1704 17620920 RAIsGDLtAEEELDK CAC1F_C X -CSNK2A1 CK2A1 P68400 human NCL 17975 P09405 Ncl mouse S28 452262 PKEVEEDsEDEEMsE X -CSNK2A1 CK2A1 P68400 human EIF5 1983 P55010 EIF5 human T207 3339005 DDDWGEDttEEAQRR X -CSNK2A1 CK2A1 P68400 human DOK7 231134 Q18PE0 Dok7 mouse S266 41621606 DDRSLsssSSEASHs X -CSNK2A1 CK2A1 P68400 human CDH1 12550 P09803 Cdh1 mouse S840 465565 LVFDYEGsGsEAAsL CADH_Y-type_LIR X -CSNK2A1 CK2A1 P68400 human SLITRK1 114798 Q96PX8 SLITRK1 human S695 4749248 DCGSHSLsD______ X -CSNK2A1 CK2A1 P68400 human HMGN1 3150 P05114 HMGN1 human S99 451698 AGEkEAksD______ X -CSNK2A1 CK2A1 P68400 human PACS-1 55690 Q6VY07 PACS1 human S278 2911721 SPDIDNYsEEEEESF X -CSNK2A1 CK2A1 P68400 human Ikaros 22778 Q03267 Ikzf1 mouse T23 4828303 ESPPVSDtPDEGDEP X -CSNK2A1 CK2A1 P68400 human PLD1 5337 Q13393 PLD1 human S611 465587 FKLFHPssESEQGLT X -CSNK2A1 CK2A1 P68400 human MRE11A 4361 P49959 MRE11 human S688 449207 sKGVDFEssEDDDDD X X -CSNK2A1 CK2A1 P68400 human MCR 4306 P08235 NR3C2 human S111 386186601 SMGLYMDsVRDADYS X X -CSNK2A1 CK2A1 P68400 human JNK2 5601 P45984 MAPK9 human S407 447648 STEQtLAsDTDSSLD X -CSNK2A1 CK2A1 P68400 human Jun 3725 P05412 JUN human S243 450451 PGEtPPLsPIDMEsQ X 2994 -CSNK2A1 CK2A1 P68400 human p47phox 653361 P14598 NCF1 human S348 451728 PGPQsPGsPLEEERQ X -CSNK2A1 CK2A1 P68400 human ATF-1 466 P18846 ATF1 human S47 15725601 EsQDSSDsIGssQKA pKID X -CSNK2A1 CK2A1 P68400 human N-WASP 682507 O08816 Wasl rat S480 3149548 KRSKAIHssDEDEDD X X -CSNK2A1 CK2A1 P68400 human OTUB1 55611 Q96FW1 OTUB1 human S16 3208998 QkQEPLGsDsEGVNC X X -CSNK2A1 CK2A1 P68400 human MRTO4 51154 Q9UKD2 MRTO4 human S235 22349546 EsTEEsDsEDDD___ X -CSNK2A1 CK2A1 P68400 human RIC8A 293614 Q80ZG1 Ric8a rat S435 468627 GRPEGQYsEDEDtDT Ric8 X -CSNK2A1 CK2A1 P68400 human FANCD2 2177 Q9BXW9 FANCD2 human S891 1871613601 tLsEEkNsECDPtPs FancD2 X -CSNK2A1 CK2A1 P68400 human TLE1 7088 Q04724 TLE1 human S239 454385 KDSsHYDsDGDKsDD X X -CSNK2A1 CK2A1 P68400 human CDH1 999 P12830 CDH1 human S850 1270900 AsLSsLNsSEsDKDQ CADH_Y-type_LIR X -CSNK2A1 CK2A1 P68400 human TDP-43 23435 Q13148 TARDBP human S410 3084601 ssMDskssGWGM___ X -CSNK2A1 CK2A1 P68400 human BMI1 648 P35226 BMI1 human S110 56654163 SADAANGsNEDrGEV X -CSNK2A1 CK2A1 P68400 human WAVE2 10163 Q9Y6W5 WASF2 human S497 6377639 EFDEDDWsD______ X -CSNK2A1 CK2A1 P68400 human AIP 9049 O00170 AIP human S43 10888700 FHYRTLHsDDEGTVL FKBP_C X -CSNK2A1 CK2A1 P68400 human SLC18A2 25549 Q01827 Slc18a2 rat S514 465596 GDDEEsEsD______ X -CSNK2A1 CK2A1 P68400 human calsequestrin 2 845 O14958 CASQ2 human S385 1868253002 DDDDDDNsDEEDNDD X -CSNK2A1 CK2A1 P68400 human HMGA1 iso2 3159 P17096-2 HMGA1 human S92 452255 EGIsQEssEEEQ___ X -CSNK2A1 CK2A1 P68400 human NCAPH 23397 Q15003 NCAPH human S570 470129 PGLQAADsDDEDLDD Cnd2 X -CSNK2A1 CK2A1 P68400 human TINF2 26277 Q9BSI4 TINF2 human S396 17554823 IGDLVLDsDEEENGQ X -CSNK2A1 CK2A1 P68400 human HOXB7 3217 P09629 HOXB7 human S133 465570 IYPWMRssGTDRKRG X -CSNK2A1 CK2A1 P68400 human GMF-beta 2764 P60983 GMFB human S53 451488 DEELEGIsPDELkDE Cofilin_ADF X -CSNK2A1 CK2A1 P68400 human SLC3A2 6520 P08195 SLC3A2 human S408 6003503 TssyLsDsGsTGEHT X -CSNK2A1 CK2A1 P68400 human FMR1 2332 Q06787 FMR1 human S500 469583 NSEASNAsETESDHR FXMRP1_C_core X -CSNK2A1 CK2A1 P68400 human DNAJB2 3300 P25686 DNAJB2 human S250 34499810 CPLDsDLsEDEDLQL X X -CSNK2A1 CK2A1 P68400 human FAF1 11124 Q9UNN5 FAF1 human S289 450286 ITDVHMVsDsDGDDF X -CSNK2A1 CK2A1 P68400 human CFTR 12638 P26361 Cftr mouse S422 3333404 SNGDRKHsSDENNVS X -CSNK2A1 CK2A1 P68400 human LASS4 79603 Q9HA82 CERS4 human S342 7102766 QMEKDIRsDVEEsDs X -CSNK2A1 CK2A1 P68400 human MDC1 9656 Q14676 MDC1 human S218 4213800 PFAFNLNsDtDVEEG X -CSNK2A1 CK2A1 P68400 human RRAD 6236 P55042 RRAD human S257 457395 QIRLRRDsKEANARR X -CSNK2A1 CK2A1 P68400 human CD5 921 P06127 CD5 human S482 450126 SsMQPDNssDsDyDL X X -CSNK2A1 CK2A1 P68400 human APOE 348 P02649 APOE human S314 457115 tsAAPVPsDNH____ X -CSNK2A1 CK2A1 P68400 human FANCD2 2177 Q9BXW9 FANCD2 human S898 1871613602 sECDPtPsHRGQLNk FancD2 X -CSNK2A1 CK2A1 P68400 human CFTR 1080 P13569 CFTR human T421 1382554800 QNNNNRktsNGDDsL X -CSNK2A1 CK2A1 P68400 human DTD1 92675 Q8TEA8 DTD1 human S194 3072143 tPRKEDRsAssGAEG X -CSNK2A1 CK2A1 P68400 human GBF1 8729 Q92538 GBF1 human S297 1170755601 TDsGLEFsSQTTSKE X X -CSNK2A1 CK2A1 P68400 human PhLP 5082 Q13371 PDCL human S296 465538 AtCHsEDsDLEID__ Phosducin X -CSNK2A1 CK2A1 P68400 human HSP70 3303 P0DMV8 HSPA1B human T636 18010647 GGsGsGPtIEEVD__ X -CSNK2A1 CK2A1 P68400 human LASS6 253782 Q6ZMG9 CERS6 human S347 22350312 RsDIEsssDEEDSEP X -CSNK2A1 CK2A1 P68400 human caveolin-1 403980 P33724 CAV1 dog S88 451561 FDGIWKAsFTTFTVT Caveolin X -CSNK2A1 CK2A1 P68400 human HMGN1 3150 P05114 HMGN1 human S89 451697 ktEEsPAsDEAGEkE HMG14_17 X -CSNK2A1 CK2A1 P68400 human NFE2L1 18023 Q61985 Nfe2l1 mouse S497 28700306 EGAVGYSsDSETLDL X -CSNK2A1 CK2A1 P68400 human Calmodulin 801 P0DP23 CALM3 human S102 448706 kDGNGyIsAAELrHV EF-hand_7 X -CSNK2A1 CK2A1 P68400 human SSRP1 6749 Q08945 SSRP1 human S510 455268 SSSNEGDsDRDEKKR X -CSNK2A1 CK2A1 P68400 human HHEX 3087 Q03014 HHEX human S163 7430500 FETQKYLsPPERKRL Homeodomain X -CSNK2A1 CK2A1 P68400 human ITCH 16396 Q8C863 Itch mouse T425 470111 VNHNTRItQWEDPRS WW X -CSNK2A1 CK2A1 P68400 human NKX2-5 18091 P42582 Nkx2-5 mouse S163 465563 FKQQRYLsAPERDQL Homeodomain X -CSNK2A1 CK2A1 P68400 human IL16 3603 Q14005 IL16 human S743 11280302 MPLQPNAsLNEEEGT X -CSNK2A1 CK2A1 P68400 human GRB14 2888 Q14449 GRB14 human S358 31834913 MHPYQGRsGCSsQSI X -CSNK2A1 CK2A1 P68400 human MDC1 9656 Q14676 MDC1 human S402 3196337 QAsMVINsDtDDEEE X -CSNK2A1 CK2A1 P68400 human Jun 3725 P05412 JUN human S249 455367 LsPIDMEsQERIkAE X X -CSNK2A1 CK2A1 P68400 human DAXX 1616 Q9UER7 DAXX human S737 467726 PEEIIVLsDsD____ X X -CSNK2A1 CK2A1 P68400 human MSK1 9252 O75582 RPS6KA5 human S757 12159001 stsTETRssssESSH X -CSNK2A1 CK2A1 P68400 human PLD1 5337 Q13393 PLD1 human S610 465586 HFKLFHPssESEQGL X -CSNK2A1 CK2A1 P68400 human PAX7 18509 P47239 Pax7 mouse S201 50592106 GNRLDEGsDVEsEPd X -CSNK2A1 CK2A1 P68400 human SSRP1 6749 Q08945 SSRP1 human S688 456296 KRRRSEDsEEEELAS X -CSNK2A1 CK2A1 P68400 human NHE5 6553 Q14940 SLC9A5 human S712 20832301 EEEEsDssEtEKEDD X -CSNK2A1 CK2A1 P68400 human PSEN2 5664 P49810 PSEN2 human S9 449961 LTFMAsDsEEEVCDE X -CSNK2A1 CK2A1 P68400 human XRCC1 7515 P18887 XRCC1 human S418 3181471 EEDEAsHsGGsGDEA X -CSNK2A1 CK2A1 P68400 human ATF-4 468 P18848 ATF4 human S215 27833501 IKEEDTPsDNDsGIC X X -CSNK2A1 CK2A1 P68400 human AQP4 25293 P47863 Aqp4 rat S285 449922 MEVEDNRsQVEtEDL X -CSNK2A1 CK2A1 P68400 human SHOX 6473 O15266 SHOX human S106 457680 EKREDVKsEDEDGQT X X -CSNK2A1 CK2A1 P68400 human IHPK2 51447 Q9UHH9 IP6K2 human S356 18258507 AEDLEDLsEEsADES IPK X -CSNK2A1 CK2A1 P68400 human PPAR-gamma iso2 19016 P37238-2 Pparg mouse S21 12170301 GIsSVDLsVMEDHSH PPARgamma_N X -CSNK2A1 CK2A1 P68400 human IkB-alpha 4792 P25963 NFKBIA human S36 448204 RHDsGLDsMkDEEyE X 5210; 9246 -CSNK2A1 CK2A1 P68400 human PTPRCAP 5790 Q14761 PTPRCAP human S153 23136094 RAEEARDsDtEGDLV PTPRCAP X X -CSNK2A1 CK2A1 P68400 human DNAJC1 607587 F1PMR9 DNAJC1 dog S486 469721 DISEQKEssDEESQK X -CSNK2A1 CK2A1 P68400 human GRB14 2888 Q14449 GRB14 human S370 14567758 QSIsPMRsIsENsLV BPS X -CSNK2A1 CK2A1 P68400 human ARRB2 409 P32121 ARRB2 human T382 455373 EFDTNYAtDDDIVFE X -CSNK2A1 CK2A1 P68400 human PPP1R2 5504 P41236 PPP1R2 human S121 449052 yRIQEQEssGEEDsD IPP-2 X -CSNK2A1 CK2A1 P68400 human TOP1 7150 P11387 TOP1 human S506 27276101 ADTVGCCsLRVEHIN Topoisom_I X -CSNK2A1 CK2A1 P68400 human SRPK1 6732 Q96SB4 SRPK1 human S555 456013 DYLFEPHsGEEYTRD Pkinase X -CSNK2A1 CK2A1 P68400 human CADPS 26989 Q62717 Cadps rat S5 7712502 ___MLDPsssEEEsD X -CSNK2A1 CK2A1 P68400 human PIAS1 8554 O75925 PIAS1 human S467 4700788 IDLtIDsssDEEEEE X X -CSNK2A1 CK2A1 P68400 human MYH2 4620 Q9UKX2 MYH2 human S1921 3090700 ERADIAEsQVNKLRV Myosin_tail_1 X -CSNK2A1 CK2A1 P68400 human CADPS 26989 Q62717 Cadps rat S6 7712500 __MLDPsssEEEsDE X -CSNK2A1 CK2A1 P68400 human SCN2A 24766 P04775 Scn2a rat S1124 6003506 LNTEEFSsEsDMEES Na_trans_assoc X -CSNK2A1 CK2A1 P68400 human MYH10 4628 P35580 MYH10 human S1952 465599 QLHLEGAsLELsDDD X -CSNK2A1 CK2A1 P68400 human SIRT1 23411 Q96EB6 SIRT1 human S661 6855924 GAEVYsDsEDDVLSS X X -CSNK2A1 CK2A1 P68400 human PHF8 23133 Q9UPP1 PHF8 human S854 3216123 DAEYIyPsLEsDDDD X X -CSNK2A1 CK2A1 P68400 human SAT 6303 P21673 SAT1 human S146 11390100 FYKRRGAsDLsSEEG X -CSNK2A1 CK2A1 P68400 human TOP2A 7153 P11388 TOP2A human S1525 448764 PIKyLEEsDEDDLF_ X -CSNK2A1 CK2A1 P68400 human IGFBP1 3484 P08833 IGFBP1 human S144 451659 NFHLMAPsEEDHSIL X X -CSNK2A1 CK2A1 P68400 human ataxin-3 4287 P54252 ATXN3 human S347 9441000 LQAAVTMsLETVRND UIM X -CSNK2A1 CK2A1 P68400 human calsequestrin 1 100009095 P07221 CASQ1 rabbit T381 451337 VLEGEINtEDDDDED Calsequestrin X -CSNK2A1 CK2A1 P68400 human RIGI 23586 O95786 RIGI human T770 17484200 DsILRLQtWDEAVFR X X -CSNK2A1 CK2A1 P68400 human IGFBP3 3486 P17936 IGFBP3 human S194 10902818 KVDyEsQstDtQNFs X -CSNK2A1 CK2A1 P68400 human SMC3 9126 Q9UQE7 SMC3 human S1067 453059 GDVEGsQsQDEGEGs SMC_N X -CSNK2A1 CK2A1 P68400 human SSB 6741 P05455 SSB human S366 449301 GkktKFAsDDEHDEH X X -CSNK2A1 CK2A1 P68400 human IkB-alpha 4792 P25963 NFKBIA human S283 451523 NLQMLPEsEDEEsyD X X -CSNK2A1 CK2A1 P68400 human Myb 4602 P10242 MYB human S12 448187 PRHSIYssDEDDEDF X -CSNK2A1 CK2A1 P68400 human XRCC1 7515 P18887 XRCC1 human S416 3181468 ssEEDEAsHsGGsGD X -CSNK2A1 CK2A1 P68400 human BIK 638 Q13323 BIK human S35 448349 EVLGMtDsEEDLDPM bcl-2I13 X -CSNK2A1 CK2A1 P68400 human PhLP 5082 Q13371 PDCL human S25 465539 sssEDEDsDHEDKDR X X -CSNK2A1 CK2A1 P68400 human CK2B 1460 P67870 CSNK2B human S3 447647 _____MsssEEVsWI X -CSNK2A1 CK2A1 P68400 human XRCC1 7515 P18887 XRCC1 human S408 3181459 YLMAGPGsssEEDEA X -CSNK2A1 CK2A1 P68400 human LASS5 91012 Q8N5B7 CERS5 human S350 18260879 KVSKDDRsDVEsssE X -CSNK2A1 CK2A1 P68400 human MCR 4306 P08235 NR3C2 human S459 386186600 FMDGSYFsFMDDkDY X X -CSNK2A1 CK2A1 P68400 human MDC1 9656 Q14676 MDC1 human S299 477757 sQPPGEDsDtDVDDD X -CSNK2A1 CK2A1 P68400 human TPM1 22003 P58771 Tpm1 mouse S283 451804 HALNDMtsI______ Tropomyosin X -CSNK2A1 CK2A1 P68400 human CREB 1385 P16220 CREB1 human S97 451808 TIAEsEDsQEsVDsV X -CSNK2A1 CK2A1 P68400 human CTDP1 9150 Q9Y5B0 CTDP1 human S942 455466 ssNEDEGsssEADEM FCP1_C X -CSNK2A1 CK2A1 P68400 human MYH9 4627 P35579 MYH9 human S1916 451181 AMNREVssLkNkLRr Myosin_tail_1 X -CSNK2A1 CK2A1 P68400 human TELO2 9894 Q9Y4R8 TELO2 human S487 15668105 AQLAGsDsDLDsDDE X X -CSNK2A1 CK2A1 P68400 human GAP43 14432 P06837 Gap43 mouse S193 449598 PTEtAEssQAEEEkD Neuromodulin X -CSNK2A1 CK2A1 P68400 human CBX1 12412 P83917 Cbx1 mouse S89 2906737 GGkRKADsDsEDKGE X -CSNK2A1 CK2A1 P68400 human MRE11A 4361 P49959 MRE11 human S558 3191332 AEQMANDsDDsISAA X X -CSNK2A1 CK2A1 P68400 human Sialoprotein-2 281233 Q28862 IBSP cow S76 457543 ENGNGDssEEEEEEE BSP_II X -CSNK2A1 CK2A1 P68400 human TRHR 25570 Q01717 Trhr rat S383 465594 YVsTtKVsFDDtCLA X -CSNK2A1 CK2A1 P68400 human TIF1A 54700 Q9NYV6 RRN3 human S170 470001 KEGDVDVsDsDDEDD RRN3 X X -CSNK2A1 CK2A1 P68400 human NCL 25135 P13383 Ncl rat S213 466007 EEEEEDDsEEEVMEI X -CSNK2A1 CK2A1 P68400 human DDHD1 338047 O46606 DDHD1 cow S716 465583 AKDPTSIsENEGIST DDHD X -CSNK2A1 CK2A1 P68400 human ataxin-3 iso1 4287 P54252-1 ATXN3 human S236 9441003 LQRALALsRQEIDME UIM X -CSNK2A1 CK2A1 P68400 human Calmodulin 24242 P0DP29 Calm3 rat T80 448704 MARKMkDtDsEEEIR X X -CSNK2A1 CK2A1 P68400 human CADPS 26989 Q62717 Cadps rat S7 7712501 _MLDPsssEEEsDEI X -CSNK2A1 CK2A1 P68400 human PER2 18627 O54943 Per2 mouse S693 468399 ETVEDMAsGPEsLDG X X -CSNK2A1 CK2A1 P68400 human ABCB1B 18669 P06795 Abcb1b mouse S665 22634902 KsPLIRRsIYRsVHR X -CSNK2A1 CK2A1 P68400 human FUNDC1 139341 Q8IVP5 FUNDC1 human S13 2025373 PPPQDyEsDDDsyEV X X -CSNK2A1 CK2A1 P68400 human PIAS1 8554 O75925 PIAS1 human S466 4700782 VIDLtIDsssDEEEE X X -CSNK2A1 CK2A1 P68400 human XRCC1 7515 P18887 XRCC1 human S485 451510 QDNGAEDsGDtEDEL X X -CSNK2A1 CK2A1 P68400 human HSP105 15505 Q61699 Hsph1 mouse S509 448756 PtEEEDGssLEADME HSP70 X -CSNK2A1 CK2A1 P68400 human PAR-4 5074 Q96IZ0 PAWR human S231 476476 GRyksttsVsEEDVS X -CSNK2A1 CK2A1 P68400 human MDM2 4193 Q00987 MDM2 human S260 454923 sLDsEDYsLsEEGQE X -CSNK2A1 CK2A1 P68400 human ataxin-3 4287 P54252 ATXN3 human S335 9441001 SDLGDAMsEEDMLQA UIM X -CSNK2A1 CK2A1 P68400 human CTCF 396274 Q08705 CTCF chicken S604 448302 GRKRKMRsKKEDssD X -CSNK2A1 CK2A1 P68400 human Sialoprotein-2 281233 Q28862 IBSP cow S67 457541 VQsSsDssEENGNGD BSP_II X -CSNK2A1 CK2A1 P68400 human SLC28A2 60423 Q62773 Slc28a2 rat S46 4700175 EEVTQGHsLKDGLGH X -CSNK2A1 CK2A1 P68400 human STARD10 10809 Q9Y365 STARD10 human S284 483984 GGAGGEGsDDDtsLt X -CSNK2A1 CK2A1 P68400 human DMBT1 12945 Q60997 Dmbt1 mouse T2073 13201902 AFTLGRRtHIDRGQP X -CSNK2A1 CK2A1 P68400 human NHE3 100009430 P26432 NHE-3 rabbit S719 3496800 KERELELsDPEEAPD X X -CSNK2A1 CK2A1 P68400 human HOXB7 3217 P09629 HOXB7 human T203 465571 NKTAGPGttGQDRAE X -CSNK2A1 CK2A1 P68400 human HMGN1 614915 P02316 HMGN1 cow S90 451697 KNEESPAsDEAEEKE HMG14_17 X -CSNK2A1 CK2A1 P68400 human HMGA1 iso2 3159 P17096-2 HMGA1 human S91 452254 EEGIsQEssEEEQ__ X -CSNK2A1 CK2A1 P68400 human OAZ2 18247 O08608 Oaz2 mouse S186 11507801 YPLDQNLsDED____ X -CSNK2A1 CK2A1 P68400 human HOXB7 3217 P09629 HOXB7 human T204 465572 KTAGPGttGQDRAEA X -CSNK2A1 CK2A1 P68400 human RIC8A 293614 Q80ZG1 Ric8a rat T440 468628 QYsEDEDtDTEEYRE Ric8 X -CSNK2A1 CK2A1 P68400 human TRF1 7013 P54274 TERF1 human T122 2481000 LTACQLRtIYICQFL TRF X X -CSNK2A1 CK2A1 P68400 human H2A.1 8329 P0C0S8 H2AC17 human Y57 1874775700 YLAAVLEyLTAEILE Histone X X -CSNK2A1 CK2A1 P68400 human SCN2A 24766 P04775 Scn2a rat S1126 6003507 TEEFSsEsDMEESKE Na_trans_assoc X -CSNK2A1 CK2A1 P68400 human NPHP1 4867 O15259 NPHP1 human S126 26395105 EEsEsEDsEDSGGEE X X -CSNK2A1 CK2A1 P68400 human MUSK 18198 Q61006 Musk mouse S680 26367601 TVCSLSHsDLSTRAR PK_Tyr_Ser-Thr X -CSNK2A1 CK2A1 P68400 human LASS6 253782 Q6ZMG9 CERS6 human S341 40511820 KVSKDDRsDIEsssD X -CSNK2A1 CK2A1 P68400 human MDC1 9656 Q14676 MDC1 human S329 453669 QPFGFIDsDtDAEEE X -CSNK2A1 CK2A1 P68400 human IkB-alpha 4792 P25963 NFKBIA human S288 451524 PEsEDEEsyDtEsEF X X -CSNK2A1 CK2A1 P68400 human HSP90B 3326 P08238 HSP90AB1 human S718 3177650 LEGDEDAsRMEEVD_ X -CSNK2A1 CK2A1 P68400 human IRS1 25467 P35570 Irs1 rat S99 449931 HFAIAADsEAEQDSW PH X -CSNK2A1 CK2A1 P68400 human SLC3A2 6520 P08195 SLC3A2 human S527 6003505 LsLFRRLsDQRsKER X -CSNK2A1 CK2A1 P68400 human FOXC2 14234 Q61850 Foxc2 mouse S124 36950200 NSIRHNLsLNECFVK Forkhead X X -CSNK2A1 CK2A1 P68400 human MRLC2 103910 O14950 MYL12B human T135 466341 tTMGDrFtDEEVDEL EF-hand_11 X -CSNK2A1 CK2A1 P68400 human TELO2 9894 Q9Y4R8 TELO2 human S491 15668106 GsDsDLDsDDEFVPY X X -CSNK2A1 CK2A1 P68400 human Huntingtin 3064 P42858 HTT human S13 10206805 kLMkAFEsLksFQQQ X -CSNK2A1 CK2A1 P68400 human XRCC1 7515 P18887 XRCC1 human S475 451509 IDIEGVQsEGQDNGA X -CSNK2A1 CK2A1 P68400 human Akt1 207 P31749 AKT1 human S129 450019 sGsPsDNsGAEEMEV X X 13461 -CSNK2A1 CK2A1 P68400 human ACE 1636 P12821 ACE human S1299 450699 SHGPQFGsEVELRHS X -CSNK2A1 CK2A1 P68400 human MCM2 4171 P49736 MCM2 human S41 452312 RtDALtssPGRDLPP X -CSNK2A1 CK2A1 P68400 human CDC34 997 P49427 CDC34 human S203 448687 APAPDEGsDLFYDDY X X -CSNK2A1 CK2A1 P68400 human Lu 4059 P50895 BCAM human S598 1713901 GEPGLsHsGsEQPEQ X -CSNK2A1 CK2A1 P68400 human XRCC1 7515 P18887 XRCC1 human S578 40274402 GELEDYMsDRVQFVI BRCT_2 X -CSNK2A1 CK2A1 P68400 human RRAD 6236 P55042 RRAD human S273 457396 AGTRRREsLGKKAKR X -CSNK2A1 CK2A1 P68400 human TAP 317724 P41541 USO1 cow S941 450465 EEEDELEsGDQDDED Uso1_p115_C X -CSNK2A1 CK2A1 P68400 human DTD1 92675 Q8TEA8 DTD1 human S204 476435 sGAEGDVssErEP__ X -CSNK2A1 CK2A1 P68400 human MDC1 9656 Q14676 MDC1 human T220 4213801 AFNLNsDtDVEEGQQ X -CSNK2A1 CK2A1 P68400 human ABCF1 23 Q8NE71 ABCF1 human S140 454452 AALIQDQsEEEEEEE X -CSNK2A1 CK2A1 P68400 human XRCC1 7515 P18887 XRCC1 human S525 451451 stDENtDsEEHQEPP X -CSNK2A1 CK2A1 P68400 human DZIP1 66573 Q8BMD2 Dzip1 mouse S714 21241900 DTDWTEGsEMDDSDF X X -CSNK2A1 CK2A1 P68400 human CD6 923 P30203 CD6 human S482 28095003 PEDSDsGsDsDYEHY X -CSNK2A1 CK2A1 P68400 human HSP90A 3320 P07900 HSP90AA1 human S263 448662 PEIEDVGsDEEEEKK HSP90 X -CSNK2A1 CK2A1 P68400 human eIF3-alpha 8669 O75822 EIF3J human S127 3177700 LKkLQEEsDLELAkE eIF3_subunit X -CSNK2A1 CK2A1 P68400 human DNAJC1 607587 F1PMR9 DNAJC1 dog S487 469722 ISEQKEssDEESQKK X -CSNK2A1 CK2A1 P68400 human ATF-1 466 P18846 ATF1 human S36 465558 AQQVSSLsESEEsQD X X -CSNK2A1 CK2A1 P68400 human CARD9 64170 Q9H257 CARD9 human T531 1206001 NTTGSDNtDtEGS__ X X -CSNK2A1 CK2A1 P68400 human WASP 7454 P42768 WAS human S484 449295 RSRAIHssDEGEDQA X X -CSNK2A1 CK2A1 P68400 human Sialoprotein-2 281233 Q28862 IBSP cow S98 8165300 NNGGNEDsDENEDEE BSP_II X -CSNK2A1 CK2A1 P68400 human BRCA1 672 P38398 BRCA1 human S1572 465559 ESGISLFsDDPEsDP X -CSNK2A1 CK2A1 P68400 human CCNH 902 P51946 CCNH human T315 455993 KHEEEEWtDDDLVEs X -CSNK2A1 CK2A1 P68400 human CTCF 396274 Q08705 CTCF chicken S609 448303 MRsKKEDssDsEENA X -CSNK2A1 CK2A1 P68400 human HMGA2 15364 P52927 Hmga2 mouse S104 469758 EEtssQEsAEED___ X -CSNK2A1 CK2A1 P68400 human RIGI 23586 O95786 RIGI human S855 17484201 PKPkQFssFEkRAKI RIG-I_C-RD X X -CSNK2A1 CK2A1 P68400 human HHEX 3087 Q03014 HHEX human S177 7430501 LAKMLQLsERQVKTW Homeodomain X -CSNK2A1 CK2A1 P68400 human EIF5 1983 P55010 EIF5 human S390 448030 KEAEEEssGGEEEDE W2 X X -CSNK2A1 CK2A1 P68400 human NCL 25135 P13383 Ncl rat S187 466006 AAPAAPAsEDEDEED X -CSNK2A1 CK2A1 P68400 human DNMT3A 13435 O88508 Dnmt3a mouse S386 17548178 LFPACHDsDEsDSGK X -CSNK2A1 CK2A1 P68400 human SRF 6722 P11831 SRF human S85 451801 GsEGDsEsGEEEELG X -CSNK2A1 CK2A1 P68400 human GAP43 14432 P06837 Gap43 mouse T89 449600 EGDGsAttDAAPAts Neuromodulin X -CSNK2A1 CK2A1 P68400 human PGRMC1 10857 O00264 PGRMC1 human S181 452525 GEEPtVysDEEEPkD X -CSNK2A1 CK2A1 P68400 human RRAD 6236 P55042 RRAD human S214 457394 LVRSREVsVDEGRAC Ras X -CSNK2A1 CK2A1 P68400 human DLG3 iso2 1741 Q92796-2 DLG3 human S295 4710993 QGVTSNtsDSESSSK X X -CSNK2A1 CK2A1 P68400 human CDC34 997 P49427 CDC34 human S222 448688 EVEEEADsCFGDDED X X -CSNK2A1 CK2A1 P68400 human DNMT3A 1788 Q9Y6K1 DNMT3A human S390 17548178 LFPVCHDsDEsDTAK X X -CSNK2A1 CK2A1 P68400 human TUBB3 10381 Q13509 TUBB3 human S444 451154 YEDDEEEsEAQGPK_ X -CSNK2A1 CK2A1 P68400 human IHPK2 51447 Q9UHH9 IP6K2 human S347 478422 RPEVVLDsDAEDLED IPK X -CSNK2A1 CK2A1 P68400 human ABCF1 23 Q8NE71 ABCF1 human S109 453457 KKLsVPtsDEEDEVP X -CSNK2A1 CK2A1 P68400 human DDIT3 1649 P35638 DDIT3 human S30 455503 EDLQEVLssDENGGT X -CSNK2A1 CK2A1 P68400 human NFkB-p65 5970 Q04206 RELA human S529 447799 GLPNGLLsGDEDFSs X X 71254; 96874; 78764 -CSNK2A1 CK2A1 P68400 human JNK2 5601 P45984 MAPK9 human T404 447650 SSMSTEQtLAsDTDS X -CSNK2A1 CK2A1 P68400 human SGT1 11319 O95905 ECD human S503 3178821 LGPRPNEsDsDDLDD SGT1 X -CSNK2A1 CK2A1 P68400 human DHFR 1719 P00374 DHFR human S145 25735921 RIMQDFEsDTFFPEI DHFR_1 X -CSNK2A1 CK2A1 P68400 human POLR2F 83503 O88828 Polr2f rat S2 465588 ______MsDNEDNFD X -CSNK2A1 CK2A1 P68400 human ANP32A 8125 P39687 ANP32A human S158 459186 DDKEAPDsDAEGyVE LRR_9 X -CSNK2A1 CK2A1 P68400 human SRPK1 6732 Q96SB4 SRPK1 human S51 456012 QEEEILGsDDDEQED X -CSNK2A1 CK2A1 P68400 human MUSK 18198 Q61006 Musk mouse S697 26367602 SPGPPPLsCAEQLCI PK_Tyr_Ser-Thr X -CSNK2A1 CK2A1 P68400 human HSP90A 3320 P07900 HSP90AA1 human S726 3180213 LEGDDDtsRMEEVD_ X -CSNK2A1 CK2A1 P68400 human ABCB1B 18669 P06795 Abcb1b mouse S669 22634901 IRRsIYRsVHRKQDQ X -CSNK2A1 CK2A1 P68400 human eIF2B-epsilon 100009393 P47823 EIF2B5 rabbit S718 449908 KEAEEEssEDD____ W2 X X -CSNK2A1 CK2A1 P68400 human Notch 1 4851 P46531 NOTCH1 human S1900 20831302 GGLEtGNsEEEEDAP Ank_2 X X -CSNK2A1 CK2A1 P68400 human MDC1 9656 Q14676 MDC1 human T378 477989 EsQAGsDtDVEEGKA X -CSNK2A1 CK2A1 P68400 human Calmodulin 801 P0DP23 CALM3 human S82 448705 RkMkDtDsEEEIrEA X X -CSNK2A1 CK2A1 P68400 human Caldesmon 373965 P12957 CALD1 chicken S26 457417 RLEAERLsyQRNDDD X -CSNK2A1 CK2A1 P68400 human AATF 26574 Q9NY61 AATF human S320 460426 NAGsEEIssEDDELV AATF-Che1 X X -CSNK2A1 CK2A1 P68400 human GADD45GIP1 90480 Q8TAE8 GADD45GIP1 human S221 474542 PAASGAPss______ X -CSNK2A1 CK2A1 P68400 human DDIT3 1649 P35638 DDIT3 human S14 455501 PFSFGTLssWELEAW X -CSNK2A1 CK2A1 P68400 human STX1A 116470 P32851 Stx1a rat S14 451261 ELRTAKDsDDDDDVt X -CSNK2A1 CK2A1 P68400 human MCM2 4171 P49736 MCM2 human S13 473057 EsFtMAssPAQRRRG X -CSNK2A1 CK2A1 P68400 human p53 7157 P04637 TP53 human S46 447536 AMDDLMLsPDDIEQW TAD2 X 2521 -CSNK2A1 CK2A1 P68400 human IGF2R 3482 P11717 IGF2R human S2484 451244 LVsFHDDsDEDLLHI X X -CSNK2A1 CK2A1 P68400 human XPB 2071 P19447 ERCC3 human S751 454425 FGTMSSMsGADDTVy X -CSNK2A1 CK2A1 P68400 human FGF14 2259 Q92915 FGF14 human S230 54201600 VTPsKsTsASAIMNG X -CSNK2A1 CK2A1 P68400 human IFI16 3428 Q16666 IFI16 human S132 450085 GAQkRKKsTKEKAGP X -CSNK2A1 CK2A1 P68400 human Ikaros 22778 Q03267 Ikzf1 mouse S293 15404028 LSDMPYDsANYEKED X -CSNK2A1 CK2A1 P68400 human CREB iso1 81646 P15337-1 Creb1 rat S129 450092 QKRREILsRRPsYRk pKID X -CSNK2A1 CK2A1 P68400 human PDIA6 10130 Q15084 PDIA6 human S22 465562 LAVNGLYsSSDDVIE X -CSNK2A1 CK2A1 P68400 human HMGN1 3150 P05114 HMGN1 human S8 465531 MPkRkVssAEGAAkE HMG14_17 X -CSNK2A1 CK2A1 P68400 human ER-alpha 2099 P03372 ESR1 human S167 448102 GGRERLAsTNDkGSM Oest_recep X 64508; 42101 -CSNK2A1 CK2A1 P68400 human C1R 715 P00736 C1R human S206 451385 TEASGYIsSLEYPRS CUB X -CSNK2A1 CK2A1 P68400 human Akt2 208 P31751 AKT2 human S131 33402214 CGsPsDSsTTEEMEV X -CSNK2A1 CK2A1 P68400 human LEF-1 51176 Q9UJU2 LEF1 human S61 471385 kSSLVNEsEIIPASN CTNNB1_binding X -CSNK2A1 CK2A1 P68400 human NPM1 4869 P06748 NPM1 human S125 459897 AVEEDAEsEDEEEED X -CSNK2A1 CK2A1 P68400 human AATF 26574 Q9NY61 AATF human S321 460427 AGsEEIssEDDELVE AATF-Che1 X X -CSNK2A1 CK2A1 P68400 human STI1 20867 Q60864 Stip1 mouse S189 465575 LLGVDLGsMDEEEEA X -CSNK2A1 CK2A1 P68400 human Restin 6249 P30622 CLIP1 human S1364 3189736 DDLNNYDsDDQEKQS X X -CSNK2A1 CK2A1 P68400 human PEA-15 18611 Q62048 Pea15 mouse S116 450281 KDIIRQPsEEEIIKL X -CSNK2A1 CK2A1 P68400 human CFTR 1080 P13569 CFTR human S427 1382554801 ktsNGDDsLFFSNFS X -CSNK2A1 CK2A1 P68400 human DOK7 231134 Q18PE0 Dok7 mouse S346 41621603 GIATGSHssYSGSFS X -CSNK2A1 CK2A1 P68400 human ATF-1 466 P18846 ATF1 human S41 15725600 SLsESEEsQDSSDsI X -CSNK2A1 CK2A1 P68400 human p53 7157 P04637 TP53 human S6 447537 __MEEPQsDPsVEPP P53_TAD X 9285 -CSNK2A1 CK2A1 P68400 human AQP4 25293 P47863 Aqp4 rat S315 465557 DEKKGKDssGEVLss X -CSNK2A1 CK2A1 P68400 human eIF2-beta 8894 P20042 EIF2S2 human S2 451805 ______MsGDEMIFD X X -CSNK2A1 CK2A1 P68400 human CREB iso1 81646 P15337-1 Creb1 rat S143 448548 kILNDLssDAPGVPR pKID X -CSNK2A1 CK2A1 P68400 human CDH1 12550 P09803 Cdh1 mouse S855 465567 ssLNSsEsDQDQDYD CADH_Y-type_LIR X -CSNK2A1 CK2A1 P68400 human NFL 18039 P08551 Nefl mouse S473 450895 EAKDEPPsEGEAEEE X -CSNK2A1 CK2A1 P68400 human HSP90A 3320 P07900 HSP90AA1 human T725 3180216 PLEGDDDtsRMEEVD X -CSNK2A1 CK2A1 P68400 human SLC29A1 2030 Q99808 SLC29A1 human S254 486282 EtkLDLIskGEEPRA Nucleoside_tran X -CSNK2A1 CK2A1 P68400 human ECE1 iso3 1889 P42892-3 ECE1 human T9 14159846 MStYkRAtLDEEDLV X -CSNK2A1 CK2A1 P68400 human HSP90A 3320 P07900 HSP90AA1 human T36 15410982 LMSLIINtFySNkEI X X -CSNK2A1 CK2A1 P68400 human SPTAN1 20740 P16546 Sptan1 mouse S1302 14828401 TAQRLIQsHPEsAED Spectrin X -CSNK2A1 CK2A1 P68400 human NHE5 6553 Q14940 SLC9A5 human S702 20832300 AVILTVEsEEEEEEs X -CSNK2A1 CK2A1 P68400 human UBC3B 54926 Q712K3 UBE2R2 human S233 449751 DCYDDDDsGNEEs__ X X -CSNK2A1 CK2A1 P68400 human CDC34 997 P49427 CDC34 human T233 448689 DDEDDsGtEEs____ X X -CSNK2A1 CK2A1 P68400 human p53 7157 P04637 TP53 human T150 456327 VQLWVDstPPPGtRV P53 X -CSNK2A1 CK2A1 P68400 human 4E-BP1 116636 Q62622 Eif4ebp1 rat S64 447527 FLMECRNsPVAKtPP eIF_4EBP X 9451; 9456 -CSNK2A1 CK2A1 P68400 human PSEN2 5664 P49810 PSEN2 human S330 448567 MEEDsYDsFGEPsYP Presenilin; Presenilin X -CSNK2A1 CK2A1 P68400 human EEF1D 1936 P29692 EEF1D human S162 457574 DDIDLFGsDNEEEDk EF-1_beta_acid X X -CSNK2A1 CK2A1 P68400 human CD6 923 P30203 CD6 human S484 28095002 DSDsGsDsDYEHYDF X -CSNK2A1 CK2A1 P68400 human amphiphysin 273 P49418 AMPH human T387 469997 LPWDLWTtSTDLVQP X X -CSNK2A1 CK2A1 P68400 human ABCC1 4363 P33527 ABCC1 human T249 25592000 WSLNkEDtSEQVVPV X X -CSNK2A1 CK2A1 P68400 human CFTR 1080 P13569 CFTR human S511 477193 ENIIFGVsyDEyRYR ABC_tran X X -CSNK2A1 CK2A1 P68400 human ABCA1 19 O95477 ABCA1 human S1255 452019 FLKVAEEsGVDAETs X -CSNK2A1 CK2A1 P68400 human EIF5 1983 P55010 EIF5 human T208 3339004 DDWGEDttEEAQRRR X -CSNK2A1 CK2A1 P68400 human Jun 3725 P05412 JUN human T231 455366 ALkEEPQtVPEMPGE Jun X X -CSNK2A1 CK2A1 P68400 human PSEN2 5664 P49810 PSEN2 human S7 449960 _MLTFMAsDsEEEVC X -CSNK2A1 CK2A1 P68400 human FURIN 5045 P09958 FURIN human S775 469743 QEECPsDsEEDEGRG X -CSNK2A1 CK2A1 P68400 human SIRT1 93759 Q923E4 Sirt1 mouse S649 6855923 FHGAEVYsDsEDDVL X X -CSNK2A1 CK2A1 P68400 human IGFBP3 3486 P17936 IGFBP3 human S140 451463 APGNAsEsEEDRsAG X X -CSNK2A1 CK2A1 P68400 human CETN2 1069 P41208 CETN2 human T138 471512 kELGENLtDEELQEM EF-hand_7 X -CSNK2A1 CK2A1 P68400 human CALU iso15 813 O43852-15 CALU human T73 29606705 MYSHDGNtDEPEWVK X -CSNK2A1 CK2A1 P68400 human HMGN1 614915 P02316 HMGN1 cow S100 451698 AEEKEAKsD______ X -CSNK2A1 CK2A1 P68400 human DDIT3 1649 P35638 DDIT3 human S15 455502 FSFGTLssWELEAWY X -CSNK2A1 CK2A1 P68400 human DZIP1 66573 Q8BMD2 Dzip1 mouse S706 21241901 FGKSAVKsDTDWTEG X X -CSNK2A1 CK2A1 P68400 human ERK2 5594 P28482 MAPK1 human S246 6845001 HILGILGsPsQEDLN Pkinase X X -CSNK2A1 CK2A1 P68400 human XRCC1 7515 P18887 XRCC1 human S410 3181465 MAGPGsssEEDEAsH X -CSNK2A1 CK2A1 P68400 human NCL 17975 P09405 Ncl mouse S34 466005 DsEDEEMsEDEDDss X -CSNK2A1 CK2A1 P68400 human S100B 525716 P02638 S100B cow S63 465589 KVMETLDsDGDGECD EF-hand_1 X -CSNK2A1 CK2A1 P68400 human Myc 4609 P01106 MYC human S267 466014 PPTtssDsEEEQEDE Myc_N X -CSNK2A1 CK2A1 P68400 human MDC1 9656 Q14676 MDC1 human T404 3196400 sMVINsDtDDEEEVs X -CSNK2A1 CK2A1 P68400 human PPP1R2P3 153743 Q6NXS1 PPP1R2B human S121 27842901 yRIQEQEssGEEDsD IPP-2 X -CSNK2A1 CK2A1 P68400 human amphiphysin 273 P49418 AMPH human T350 469996 PEVKKEEtLLDLDFD X X -CSNK2A1 CK2A1 P68400 human MDC1 9656 Q14676 MDC1 human T331 477988 FGFIDsDtDAEEERI X -CSNK2A1 CK2A1 P68400 human Nur77 3164 P22736 NR4A1 human S152 25692904 SFQPPQLsPWDGSFG X X -CSNK2A1 CK2A1 P68400 human RNF7 9616 Q9UBF6 RNF7 human T10 449925 DVEDGEEtCALAsHS X X -CSNK2A1 CK2A1 P68400 human CREM 12916 P27699 Crem mouse T110 450058 QVATIAEtDDsADsE X -CSNK2A1 CK2A1 P68400 human HMGN1 3150 P05114 HMGN1 human S86 451696 GEtktEEsPAsDEAG HMG14_17 X -CSNK2A1 CK2A1 P68400 human PPP1R2P3 153743 Q6NXS1 PPP1R2B human S127 27842902 EssGEEDsDLsPEER IPP-2 X -CSNK2A1 CK2A1 P68400 human PD-L1 29126 Q9NZQ7 CD274 human T285 1876861204 NsKkQsDtHLEEt__ X X -CSNK2A1 CK2A1 P68400 human RAP80 51720 Q96RL1 UIMC1 human S44 470700 EDAFIVIsDsDGEEP X -CSNK2A1 CK2A1 P68400 human SIRT1 93759 Q923E4 Sirt1 mouse S154 6006902 NGFHsCEsDDDDRTS X X -CSNK2A1 CK2A1 P68400 human XPC 7508 Q01831 XPC human S94 3194024 VIKDEALsDGDDLRD X -CSNK2A1 CK2A1 P68400 human XRCC1 7515 P18887 XRCC1 human T523 451448 AGstDENtDsEEHQE X X -CSNK2A1 CK2A1 P68400 human Bcr 110279 Q6PAJ1 Bcr mouse Y178 447792 ADAEKPFyVNVEFHH X 3901 -CSNK2A1 CK2A1 P68400 human SIRT1 93759 Q923E4 Sirt1 mouse S651 6855924 GAEVYsDsEDDVLSS X X -CSNK2A1 CK2A1 P68400 human CREB iso1 81646 P15337-1 Creb1 rat S114 451809 EsEDsQEsVDsVtDs pKID X -CSNK2A1 CK2A1 P68400 human PPP1R2 5504 P41236 PPP1R2 human S122 449053 RIQEQEssGEEDsDL IPP-2 X -CSNK2A1 CK2A1 P68400 human DTD1 92675 Q8TEA8 DTD1 human S196 476434 RKEDRsAssGAEGDV X -CSNK2A1 CK2A1 P68400 human C/EBP-delta 1052 P49716 CEBPD human S57 40263800 PAMYDDEsAIDFSAY X X -CSNK2A1 CK2A1 P68400 human DZIP1 66573 Q8BMD2 Dzip1 mouse S665 13907506 TKTPPFssEEEPDEE X X -CSNK2A1 CK2A1 P68400 human TFPI 7035 P10646 TFPI human S30 451319 PAPLNADsEEDEEHT X -CSNK2A1 CK2A1 P68400 human FNIP1 96459 Q8TF40 FNIP1 human S946 4734332 sDsALGDsEsEDTGH X -CSNK2A1 CK2A1 P68400 human CDH1 999 P12830 CDH1 human S853 465567 SsLNsSEsDKDQDYD CADH_Y-type_LIR X -CSNK2A1 CK2A1 P68400 human PPAR-gamma iso2 19016 P37238-2 Pparg mouse S16 12170300 WPTNFGIsSVDLsVM PPARgamma_N X -CSNK2A1 CK2A1 P68400 human MYH10 4628 P35580 MYH10 human T1960 465601 LELsDDDtEsKtsDV X -CSNK2A1 CK2A1 P68400 human LASS4 79603 Q9HA82 CERS4 human S349 7102761 sDVEEsDssEEAAAA X -CSNK2A1 CK2A1 P68400 human IGF2R 3482 P11717 IGF2R human S2409 451243 LHGDDQDsEDEVLtI X X -CSNK2A1 CK2A1 P68400 human XRCC1 7515 P18887 XRCC1 human S518 451449 GEDPyAGstDENtDs X X -CSNK2A1 CK2A1 P68400 human PTEN 5728 P60484 PTEN human S385 448650 RYsDttDsDPENEPF X -CSNK2A1 CK2A1 P68400 human calsequestrin 2 845 O14958 CASQ2 human S393 1868253003 DEEDNDDsDDDDDE_ X -CSNK2A1 CK2A1 P68400 human CDH1 12550 P09803 Cdh1 mouse S853 465566 sLssLNSsEsDQDQD CADH_Y-type_LIR X -CSNK2A1 CK2A1 P68400 human GYS1 100008660 P13834 GYS1 rabbit S657 449790 RHSsPHQsEDEEEPR Glycogen_syn X -CSNK2A1 CK2A1 P68400 human IkB-alpha 4792 P25963 NFKBIA human S293 451525 EEsyDtEsEFTEFtE X X -CSNK2A1 CK2A1 P68400 human MDC1 9656 Q14676 MDC1 human T455 453677 ttERDsDtDVEEEEL X -CSNK2A1 CK2A1 P68400 human WAVE2 10163 Q9Y6W5 WASF2 human S484 6377638 IAVEYsDsEDDssEF X -CSNK2A1 CK2A1 P68400 human TWIST1 7291 Q15672 TWIST1 human S20 18899300 ADDSLsNsEEEPDRQ X X -CSNK2A1 CK2A1 P68400 human MDC1 9656 Q14676 MDC1 human S453 453670 QtttERDsDtDVEEE X -CSNK2A1 CK2A1 P68400 human p47phox 653361 P14598 NCF1 human S283 465579 PSMyLQKsGQDVsQA NECFESHC X -CSNK2A1 CK2A1 P68400 human MYH9 4627 P35579 MYH9 human S1943 456730 RKGAGDGsDEEVDGK X X 5026; 14611 -CSNK2A1 CK2A1 P68400 human STX1A 6804 Q16623 STX1A human S14 451261 ELRTAKDsDDDDDVA X X -CSNK2A1 CK2A1 P68400 human Calmodulin 24242 P0DP29 Calm3 rat S82 448705 RKMkDtDsEEEIREA X X -CSNK2A1 CK2A1 P68400 human RAD9A 5883 Q99638 RAD9A human S341 449817 PKsPGPHsEEEDEAE X -CSNK2A1 CK2A1 P68400 human HES6 55502 Q96HZ4 HES6 human S183 455670 GPGDDLCsDLEEAPE X -CSNK2A1 CK2A1 P68400 human p27Kip1 1027 P46527 CDKN1B human S83 451426 WQEVEkGsLPEFyyR X -CSNK2A1 CK2A1 P68400 human AATF 26574 Q9NY61 AATF human S155 3214059 GFsVQsIsDFEkFTK X -CSNK2A1 CK2A1 P68400 human coronin 1C 23603 Q9ULV4 CORO1C human S463 22996300 CNQDERIskLEQQMA X X -CSNK2A1 CK2A1 P68400 human SEC63 11231 Q9UGP8 SEC63 human S748 3215004 DsEGFEDsFEEEEEE X X -CSNK2A1 CK2A1 P68400 human HMGN1 3150 P05114 HMGN1 human S7 447788 _MPkRkVssAEGAAk HMG14_17 X -CSNK2A1 CK2A1 P68400 human ERK2 5594 P28482 MAPK1 human S248 6845000 LGILGsPsQEDLNCI Pkinase X X -CSNK2A1 CK2A1 P68400 human ANP32B 10541 Q92688 ANP32B human T244 456786 GEkRKREtDDEGEDD X X -CSNK2A1 CK2A1 P68400 human PSMA3 29670 P18422 Psma3 rat S250 451185 sLKEEDEsDDDNM__ X -CSNK2A1 CK2A1 P68400 human GAP43 14432 P06837 Gap43 mouse T95 449601 ttDAAPAtsPkAEEP Neuromodulin X -CSNK2A1 CK2A1 P68400 human NIPP-1 282319 Q28147 PPP1R8 cow S204 451338 KNsRVTFsEDDEIIN X -CSNK2A1 CK2A1 P68400 human EEF1D 100009222 P53787 EEF1D rabbit S162 457574 DDIDLFGsDEEEDKE EF-1_beta_acid X -CSNK2A1 CK2A1 P68400 human IGFBP3 3486 P17936 IGFBP3 human S138 451462 PPAPGNAsEsEEDRs X X -CSNK2A1 CK2A1 P68400 human DOK7 231134 Q18PE0 Dok7 mouse S273 41621607 sSSEASHsDISASSR X -CSNK2A1 CK2A1 P68400 human VHL 7428 P40337 VHL human S43 15573202 EEsGPEEsGPEELGA X -CSNK2A1 CK2A1 P68400 human SCN2A 24766 P04775 Scn2a rat S1112 6003508 VPIALGEsDFENLNT Na_trans_assoc X -CSNK2A1 CK2A1 P68400 human Sialoprotein-2 281233 Q28862 IBSP cow S64 457539 RFAVQsSsDssEENG BSP_II X -CSNK2A1 CK2A1 P68400 human PD-L1 29126 Q9NZQ7 CD274 human T290 56667601 sDtHLEEt_______ X X -CSNK2A1 CK2A1 P68400 human CDC34 997 P49427 CDC34 human S231 448654 FGDDEDDsGtEEs__ X X -CSNK2A1 CK2A1 P68400 human PIP4K2A 5305 P48426 PIP4K2A human S304 450664 DGEEEGEsDGTHPVG PIP5K X X -CSNK2A1 CK2A1 P68400 human A-Myb 4603 P10243 MYBL1 human S7 465555 _MAKRSRsEDEDDDL X -CSNK2A1 CK2A1 P68400 human DHFR 1719 P00374 DHFR human S168 55369311 PEYPGVLsDVQEEkG DHFR_1 X -CSNK2A1 CK2A1 P68400 human EXOSC9 5393 Q06265 EXOSC9 human S394 3194468 APIILsDsEEEEMII X X -CSNK2A1 CK2A1 P68400 human AATF 26574 Q9NY61 AATF human S288 25279151 ALKALLRsLVGLQEE AATF-Che1 X -CSNK2A1 CK2A1 P68400 human DPF3 iso2 8110 Q92784-2 DPF3 human S348 23251120 GRRsGRGsPtADKKG X X -CSNK2A1 CK2A1 P68400 human MAZ 4150 P56270 MAZ human S460 465574 PTAVGSLsGAEGVPV X X -CSNK2A1 CK2A1 P68400 human MEF2A 4205 Q02078 MEF2A human S289 456758 KGMMPPLsEEEELEL X -CSNK2A1 CK2A1 P68400 human TWIST1 7291 Q15672 TWIST1 human S18 18899301 SPADDSLsNsEEEPD X X -CSNK2A1 CK2A1 P68400 human CTCF 396274 Q08705 CTCF chicken S612 448305 KKEDssDsEENAEPD X X -CSNK2A1 CK2A1 P68400 human PDIA6 10130 Q15084 PDIA6 human S428 452832 VEDDIDLsDVELDDL X -CSNK2A1 CK2A1 P68400 human RPAP3 79657 Q9H6T3 RPAP3 human S119 1279822 HEsLsQEsEsEEdGI X X -CSNK2A1 CK2A1 P68400 human Calmodulin 801 P0DP23 CALM3 human T80 448704 MARkMkDtDsEEEIr X X -CSNK2A1 CK2A1 P68400 human CPLX2 281711 P84088 CPLX2 cow S115 474556 EEEEEEEsILDTVLK Synaphin X -CSNK2A1 CK2A1 P68400 human NCAPG 64151 Q9BPX3 NCAPG human S975 3210612 tAEADsEsDHEVPEP X -CSNK2A1 CK2A1 P68400 human Myc 4609 P01106 MYC human S264 466012 EEtPPTtssDsEEEQ Myc_N X -CSNK2A1 CK2A1 P68400 human FGF14 2259 Q92915 FGF14 human S228 54201601 PGVTPsKsTsASAIM X -CSNK2A1 CK2A1 P68400 human RIC8A 293614 Q80ZG1 Ric8a rat S522 3213321 ETMEGQLssDPDsDP X -CSNK2A1 CK2A1 P68400 human RAD51 5888 Q06609 RAD51 human T13 23305002 QLEANADtsVEEESF X -CSNK2A1 CK2A1 P68400 human NFkB-p65 309165 Q7TQN4 Rela rat S528 447799 SGLPNGLsGDEDFSs X -CSNK2A1 CK2A1 P68400 human ATF-1 466 P18846 ATF1 human S50 15725603 DSSDsIGssQKAHGI pKID X -CSNK2A1 CK2A1 P68400 human PACS2 23241 Q86VP3 PACS2 human S213 1884003504 FssEQEAsDDAVQGQ X X -CSNK2A1 CK2A1 P68400 human NHE5 6553 Q14940 SLC9A5 human S711 20832303 EEEEEsDssEtEKED X -CSNK2A1 CK2A1 P68400 human CHD-4 1108 Q14839 CHD4 human S310 471449 skRKRsssEDDDLDV X -CSNK2A1 CK2A1 P68400 human DTD1 92675 Q8TEA8 DTD1 human T187 36396302 EssKERNtPRKEDRs X -CSNK2A1 CK2A1 P68400 human GAP43 14432 P06837 Gap43 mouse T88 449599 kEGDGsAttDAAPAt Neuromodulin X -CSNK2A1 CK2A1 P68400 human XRCC1 7515 P18887 XRCC1 human S409 3181462 LMAGPGsssEEDEAs X -CSNK2A1 CK2A1 P68400 human NASP iso2 4678 P49321-2 NASP human S158 476187 tEEMPNDsVLENKSL X X -CSNK2A1 CK2A1 P68400 human PAX3 5077 P23760 PAX3 human S205 4145506 APQsDEGsDIDsEPD X -CSNK2A1 CK2A1 P68400 human XRCC1 7515 P18887 XRCC1 human T519 451450 EDPyAGstDENtDsE X X -CSNK2A1 CK2A1 P68400 human Ikaros 22778 Q03267 Ikzf1 mouse S101 4828301 GSHRDQGsSALSGVG X -CSNK2A1 CK2A1 P68400 human calpastatin 831 P20810 CAST human S655 25733148 QDPIDALsGDLDsCP X -CSNK2A1 CK2A1 P68400 human HS1 3059 P14317 HCLS1 human T16 11349500 DVSVsVEtQGDDWDt X -CSNK2A1 CK2A1 P68400 human IkB-beta 4793 Q15653 NFKBIB human S313 452013 EKsGPCSsSsDSDSG X -CSNK2A1 CK2A1 P68400 human SIRT1 23411 Q96EB6 SIRT1 human S659 6855923 FHGAEVYsDsEDDVL X X -CSNK2A1 CK2A1 P68400 human M6PR 17113 P24668 M6pr mouse S268 455293 DDQLGEEsEERDDHL Man-6-P_recep X -CSNK2A1 CK2A1 P68400 human TNFAIP1 7126 Q13829 TNFAIP1 human S278 460382 SRSRSQAsPsEDEEt X -CSNK2A1 CK2A1 P68400 human VHL 7428 P40337 VHL human S33 15573201 EEDGGEEsGAEEsGP X -CSNK2A1 CK2A1 P68400 human ARL13B 68146 Q640N2 Arl13b mouse S328 4732982 ALsQQLDsEDEQDQR X -CSNK2A1 CK2A1 P68400 human TDP-43 23435 Q13148 TARDBP human S409 3084616 GssMDskssGWGM__ X -CSNK2A1 CK2A1 P68400 human PhLP 5082 Q13371 PDCL human S19 448824 KLQYyysssEDEDsD X X -CSNK2A1 CK2A1 P68400 human HMGA1 3159 P17096 HMGA1 human S103 452255 EGIsQEssEEEQ___ X -CSNK2A1 CK2A1 P68400 human RAD9A 5883 Q99638 RAD9A human S387 449815 sPVLAEDsEGEG___ X -CSNK2A1 CK2A1 P68400 human AQP4 25293 P47863 Aqp4 rat S276 465556 AAQQTkGsYMEVEDN X -CSNK2A1 CK2A1 P68400 human EIF5 1983 P55010 EIF5 human S389 448029 LKEAEEEssGGEEED W2 X X -CSNK2A1 CK2A1 P68400 human ASCL1 17172 Q02067 Ascl1 mouse S150 453455 GAANKKMsKVETLRS HLH X X -CSNK2A1 CK2A1 P68400 human CTDP1 9150 Q9Y5B0 CTDP1 human T584 455468 EEEEEEDtDEDDHLI X -CSNK2A1 CK2A1 P68400 human GGA1 26088 Q9UJY5 GGA1 human S355 455525 EQPSASVsLLDDELM X -CSNK2A1 CK2A1 P68400 human PIAS1 8554 O75925 PIAS1 human S468 4700794 DLtIDsssDEEEEEP X X -CSNK2A1 CK2A1 P68400 human WAVE2 10163 Q9Y6W5 WASF2 human S488 6377641 YsDsEDDssEFDEDD X -CSNK2A1 CK2A1 P68400 human PDX1 18609 P52946 Pdx1 mouse S232 13421406 EQDCAVtsGEELLAV X X -CSNK2A1 CK2A1 P68400 human CTDP1 9150 Q9Y5B0 CTDP1 human S575 11276300 AGESLDQsMEEEEEE X -CSNK2A1 CK2A1 P68400 human NCL 17975 P09405 Ncl mouse S40 468243 MsEDEDDssGEEEVV X -CSNK2A1 CK2A1 P68400 human NCAM-L1 3897 P32004 L1CAM human T1172 4702537 ARPMkDEtFGEyRSL Bravo_FIGEY X -CSNK2A1 CK2A1 P68400 human XRCC4 7518 Q13426 XRCC4 human T233 2286405 DPVyDEstDEEsENQ XRCC4 X -CSNK2A1 CK2A1 P68400 human Myb 4602 P10242 MYB human S11 448186 RPRHSIYssDEDDED X -CSNK2A1 CK2A1 P68400 human ANP32A 8125 P39687 ANP32A human S204 459187 EGEEEDVsGEEEEDE X -CSNK2A1 CK2A1 P68400 human HDAC3 8841 O15379 HDAC3 human S424 455624 DHDNDKEsDVEI___ X X 3815 -CSNK2A1 CK2A1 P68400 human Sialoprotein-2 281233 Q28862 IBSP cow S154 457545 KATKEDEsDEEEEEE BSP_II X -CSNK2A1 CK2A1 P68400 human CDC37 11140 Q16543 CDC37 human S13 450034 VWDHIEVsDDEDETH CDC37_N X 13248 -CSNK2A1 CK2A1 P68400 human MRE11A 4361 P49959 MRE11 human S561 23127159 MANDsDDsISAATNK X X -CSNK2A1 CK2A1 P68400 human HMGA2 15364 P52927 Hmga2 mouse T99 7493925 PAQETEEtssQEsAE X -CSNK2A1 CK2A1 P68400 human DOK7 231134 Q18PE0 Dok7 mouse S347 41621601 IATGSHssYSGSFSS X -CSNK2A1 CK2A1 P68400 human RRAD 6236 P55042 RRAD human S290 457397 GRIVARNsRKMAFRA X -CSNK2A1 CK2A1 P68400 human PhLP 5082 Q13371 PDCL human S18 448823 EKLQYyysssEDEDs X X -CSNK2A1 CK2A1 P68400 human SEPT2 4735 Q15019 SEPTIN2 human S218 459178 yHLPDAEsDEDEDFk Septin X X -CSNK2A1 CK2A1 P68400 human PGK1 5230 P00558 PGK1 human S256 23131090 NNMEIGTsLFDEEGA PGK X X -CSNK2A1 CK2A1 P68400 human MRTO4 51154 Q9UKD2 MRTO4 human S229 14576310 LPEsAsEsTEEsDsE X -CSNK2A1 CK2A1 P68400 human PPP1R2P3 153743 Q6NXS1 PPP1R2B human S122 27842900 RIQEQEssGEEDsDL IPP-2 X -CSNK2A1 CK2A1 P68400 human RAD17 5884 O75943 RAD17 human S678 1184590201 IIIEDyEsDGt____ X -CSNK2A1 CK2A1 P68400 human EXOSC9 5393 Q06265 EXOSC9 human S392 3194465 QDAPIILsDsEEEEM X X -CSNK2A1 CK2A1 P68400 human CDC25B 994 P30305 CDC25B human S187 448747 AGsGAAsssGEDkEN M-inducer_phosp X -CSNK2A1 CK2A1 P68400 human MAT1A 4143 Q00266 MAT1A human S114 27996470 LVALEQQsPDIAQCV S-AdoMet_synt_N X X -CSNK2A1 CK2A1 P68400 human COL17A1 1308 Q9UMD9 COL17A1 human S544 484007 KIGLHsDsQEELWMF X -CSNK2A1 CK2A1 P68400 human Sialoprotein-2 P13839 Ibsp rat S153 457545 KAPKMKEsDEEEEEE BSP_II X -CSNK2A1 CK2A1 P68400 human NPHP1 4867 O15259 NPHP1 human S121 26395106 PTEEEEEsEsEDsED X X -CSNK2A1 CK2A1 P68400 human LSD1 23028 O60341 KDM1A human S137 449181 LsEDEyysEEERNAK X X -CSNK2A1 CK2A1 P68400 human MAX 4149 P61244 MAX human S2 449307 ______MsDNDDIEV X -CSNK2A1 CK2A1 P68400 human RFC1 89809 D3ZFT1 Rfc1 rat S71 452681 RIIyDsDsESEETVQ X -CSNK2A1 CK2A1 P68400 human Ikaros 22778 Q03267 Ikzf1 mouse S388 451351 REAsPsNsCQDstDt X -CSNK2A1 CK2A1 P68400 human NMDAR2B 24410 Q00960 Grin2b rat S1480 454415 EKLssIEsDV_____ NMDAR2_C X X -CSNK2A1 CK2A1 P68400 human HSP90B 3326 P08238 HSP90AB1 human S226 454114 kEREKEIsDDEAEEE HSP90 X X -CSNK2A1 CK2A1 P68400 human STX1B 24923 P61265 Stx1b rat S14 450122 ELRSAKDsDDEEEVV X -CSNK2A1 CK2A1 P68400 human VTN 7448 P04004 VTN human T69 451403 VTRGDVFtMPEDEyt X -CSNK2A1 CK2A1 P68400 human C/EBP-beta 12608 P28033 Cebpb mouse S222 408589401 kktVDKLsDEYKMRR bZIP_2 X -CSNK2A1 CK2A1 P68400 human NHE5 6553 Q14940 SLC9A5 human S709 20832304 sEEEEEEsDssEtEK X -CSNK2A1 CK2A1 P68400 human ABCA1 19 O95477 ABCA1 human T1243 452018 SYGISEttLEEIFLK X -CSNK2A1 CK2A1 P68400 human PDX1 18609 P52946 Pdx1 mouse T231 13421407 PEQDCAVtsGEELLA X X -CSNK2A1 CK2A1 P68400 human SRC-2 10499 Q15596 NCOA2 human S493 468245 LsPrHRMsPGVAGsP NCOA_u2 X -CSNK2A1 CK2A1 P68400 human HOXB6 15414 P09023 Hoxb6 mouse S214 450896 LLSASQLsAEEEEEK X -CSNK2A1 CK2A1 P68400 human PML 5371 P29590 PML human S565 2479600 VIsssEDsDAENSSS DUF3583 X X -CSNK2A1 CK2A1 P68400 human XRCC1 7515 P18887 XRCC1 human Y515 40274401 EENGEDPyAGstDEN X -CSNK2A1 CK2A1 P68400 human eEF1B 100009286 P34826 EEF1B2 rabbit S112 465598 GsDDEEEsEEAKRLR EF-1_beta_acid X -CSNK2A1 CK2A1 P68400 human TOP2A 7153 P11388 TOP2A human S1469 452243 NRRKRkPstsDDsDs DTHCT X 13072 -CSNK2A1 CK2A1 P68400 human ABCB1B 18669 P06795 Abcb1b mouse S681 22634900 QDQERRLsMKEAVDE X -CSNK2A1 CK2A1 P68400 human IGFBP1 3484 P08833 IGFBP1 human S126 451658 GsPEsPEstEITEEE X X -CSNK2A1 CK2A1 P68400 human DOK7 231134 Q18PE0 Dok7 mouse S264 41621604 GGDDRSLsssSSEAS X -CSNK2A1 CK2A1 P68400 human EIF4G2 1982 P78344 EIF4G2 human S902 12738134 ETAEEEEsEEEAD__ W2 X -CSNK2A1 CK2A1 P68400 human HDAC2 3066 Q92769 HDAC2 human S394 449930 EDAVHEDsGDEDGED X X 61458; 69238 -CSNK2A1 CK2A1 P68400 human SLBP 7884 Q14493 SLBP human T61 466351 ERRPEsFttPEGPkP X -CSNK2A1 CK2A1 P68400 human SRF 6722 P11831 SRF human S79 451803 AGALYsGsEGDsEsG X -CSNK2A1 CK2A1 P68400 human NIPP-1 282319 Q28147 PPP1R8 cow T161 451339 LGLPEEEtELDNLTE X -CSNK2A1 CK2A1 P68400 human SEC63 11231 Q9UGP8 SEC63 human S574 27440601 EEVsDKGsDsEEEET X X -CSNK2A1 CK2A1 P68400 human N-CoR1 9611 O75376 NCOR1 human S2436 468249 SAQyEtLsDsDD___ X X -CSNK2A1 CK2A1 P68400 human SGT1 11319 O95905 ECD human S518 3178827 EDFECLDsDDDLDFE SGT1 X -CSNK2A1 CK2A1 P68400 human p53 7157 P04637 TP53 human T155 455908 DstPPPGtRVRAMAI P53 X -CSNK2A1 CK2A1 P68400 human p53 7157 P04637 TP53 human S392 447535 FktEGPDsD______ X 9281 -CSNK2A1 CK2A1 P68400 human CASP2 835 P42575 CASP2 human S157 456810 LykkLRLsTDtVEHs X X -CSNK2A1 CK2A1 P68400 human IkB-alpha 4792 P25963 NFKBIA human T291 451526 EDEEsyDtEsEFTEF X X -CSNK2A1 CK2A1 P68400 human CTCF 396274 Q08705 CTCF chicken S610 448304 RsKKEDssDsEENAE X -CSNK2A1 CK2A1 P68400 human FMR1 14265 P35922 Fmr1 mouse S499 469583 NSEAsNAsETESDHR FXMRP1_C_core X -CSNK2A1 CK2A1 P68400 human Myc 4609 P01106 MYC human S265 466013 EtPPTtssDsEEEQE Myc_N X -CSNK2A1 CK2A1 P68400 human CARD9 64170 Q9H257 CARD9 human T533 1206000 TGSDNtDtEGS____ X X -CSNK2A1 CK2A1 P68400 human RAP80 51720 Q96RL1 UIMC1 human S46 470701 AFIVIsDsDGEEPKE X -CSNK2A1 CK2A1 P68400 human RFC1 89809 D3ZFT1 Rfc1 rat T110 468618 PVTYIsEtDEDDDFL X -CSNK2A1 CK2A1 P68400 human MDC1 9656 Q14676 MDC1 human T301 477987 PPGEDsDtDVDDDsR X -CSNK2A1 CK2A1 P68400 human MDC1 9656 Q14676 MDC1 human S376 477758 LQEsQAGsDtDVEEG X -CSNK2A1 CK2A1 P68400 human CADPS 26989 Q62717 Cadps rat S1281 7712503 QGISMKDsDEEDEED X -CSNK2A1 CK2A1 P68400 human Snail1 6615 O95863 SNAI1 human S92 452602 VAELTsLsDEDsGkG X X -CSNK2A1 CK2A1 P68400 human GAP43 14432 P06837 Gap43 mouse S192 449597 PPTEtAEssQAEEEk Neuromodulin X -CSNK2A1 CK2A1 P68400 human Myf-5 4617 P13349 MYF5 human S133 457385 NAIRYIEsLQELLRE HLH X -CSNK2A1 CK2A1 P68400 human Sialoprotein-2 281233 Q28862 IBSP cow S66 457540 AVQsSsDssEENGNG BSP_II X -CSNK2A1 CK2A1 P68400 human LEF-1 51176 Q9UJU2 LEF1 human S42 471384 EkIFAEIsHPEEEGD CTNNB1_binding X -CSNK2A1 CK2A1 P68400 human MCM2 4171 P49736 MCM2 human S108 456310 DVEELtAsQREAAER MCM2_N X -CSNK2A1 CK2A1 P68400 human MUS81 80198 Q96NY9 MUS81 human S87 31880574 RLQRHRTsGGDHAPD X X -CSNK2A1 CK2A1 P68400 human CDH1 12550 P09803 Cdh1 mouse S842 15754600 FDYEGsGsEAAsLss CADH_Y-type_LIR X -CSNK2A1 CK2A1 P68400 human SRF 6722 P11831 SRF human S83 451800 YsGsEGDsEsGEEEE X -CSNK2A1 CK2A1 P68400 human ARC 85383 Q62881 Nol3 rat T149 448618 SEAVQPRtPEEPELE X -CSNK2A1 CK2A1 P68400 human SERINC3 10955 Q13530 SERINC3 human S380 1255792401 ILGDTTTsGAsDEED Serinc X X -CSNK2A1 CK2A1 P68400 human caveolin-2 858 P51636 CAV2 human S23 460671 DDsysHHsGLEyADP Caveolin X X -CSNK2A1 CK2A1 P68400 human H2AX 3014 P16104 H2AX human Y57 34492711 YLAAVLEyLTAEILE Histone X X -CSNK2A1 CK2A1 P68400 human PEDF 5176 P36955 SERPINF1 human S24 455231 SSCQNPAsPPEEGSP X -CSNK2A1 CK2A1 P68400 human DZIP1 66573 Q8BMD2 Dzip1 mouse S664 13907508 STKTPPFssEEEPDE X X -CSNK2A1 CK2A1 P68400 human DNMT3A 13435 O88508 Dnmt3a mouse S389 17548182 ACHDsDEsDSGKAVE X -CSNK2A1 CK2A1 P68400 human BRMS1 25855 Q9HCU9 BRMS1 human S30 25284673 MNGEEEEsEEERSGS X -CSNK2A1 CK2A1 P68400 human MYH10 4628 P35580 MYH10 human S1965 465602 DDtEsKtsDVNEtQP X -CSNK2A1 CK2A1 P68400 human N-Myc 4613 P04198 MYCN human S261 450052 TSGEDTLsDsDDEDD Myc_N X -CSNK2A1 CK2A1 P68400 human EVI1 2122 Q03112 MECOM human S1037 482637 IGNsNHGsQsPRNVE X X -CSNK2A1 CK2A1 P68400 human LASS4 79603 Q9HA82 CERS4 human S350 7102764 DVEEsDssEEAAAAQ X -CSNK2A1 CK2A1 P68400 human CREM 12916 P27699 Crem mouse S156 450064 PKIEEEKsEEEGTPP X -CSNK2A1 CK2A1 P68400 human SIRT6 51548 Q8N6T7 SIRT6 human S338 7916000 PKRERPtsPAPHRPP X -CSNK2A1 CK2A1 P68400 human WAVE2 10163 Q9Y6W5 WASF2 human S482 6377642 RRIAVEYsDsEDDss X -CSNK2A1 CK2A1 P68400 human NCL 17975 P09405 Ncl mouse S41 468244 sEDEDDssGEEEVVI X -CSNK2A1 CK2A1 P68400 human Sialoprotein-2 281233 Q28862 IBSP cow S62 467256 LKRFAVQsSsDssEE BSP_II X -CSNK2A1 CK2A1 P68400 human eIF2B-epsilon 100009393 P47823 EIF2B5 rabbit S717 449907 LKEAEEEssEDD___ W2 X X -CSNK2A1 CK2A1 P68400 human LASS4 79603 Q9HA82 CERS4 human S347 36704607 IRsDVEEsDssEEAA X -CSNK2A1 CK2A1 P68400 human Calmodulin 801 P0DP23 CALM3 human T118 469586 tNLGEkLtDEEVDEM EF-hand_7 X -CSNK2A1 CK2A1 P68400 human DOK7 231134 Q18PE0 Dok7 mouse S249 41621605 EKRLSLLsHSGRPGs X -CSNK2A1 CK2A1 P68400 human PAX3 18505 P24610 Pax3 mouse S205 4145506 APQsDEGsDIDsEPD X -CSNK2A1 CK2A1 P68400 human PhLP 64013 Q63737 Pdcl rat S18 448823 EKLQYYYstsEDEDs X -CSNK2A1 CK2A1 P68400 human RIOK1 83732 Q9BRS2 RIOK1 human T410 797986500 MEIASQRtkEERSSQ X X -CSNK2A1 CK2A1 P68400 human FNIP1 96459 Q8TF40 FNIP1 human S939 17550026 DIPRNEssDsALGDs X -CSNK2A1 CK2A1 P68400 human PER2 18627 O54943 Per2 mouse S697 468400 DMAsGPEsLDGAAGG X -CSNK2A1 CK2A1 P68400 human HMGA1 3159 P17096 HMGA1 human S102 452254 EEGIsQEssEEEQ__ X -CSNK2A1 CK2A1 P68400 human DTD1 92675 Q8TEA8 DTD1 human S205 485755 GAEGDVssErEP___ X -CSNK2A1 CK2A1 P68400 human PIN4 5303 Q9Y237 PIN4 human S19 3188102 AGKGGAAsGSDSADK X -CSNK2A1 CK2A1 P68400 human AATF 56321 Q9JKX4 Aatf mouse S316 1868281680 LEMEDyPsFMAkRFA AATF-Che1 X X -CSNK2A1 CK2A1 P68400 human CACNA1S 100009585 P07293 CACNA1S rabbit T1579 6061600 RTIsGDLtAEEELER X -CSNK2A1 CK2A1 P68400 human RPAP3 79657 Q9H6T3 RPAP3 human S116 472436 DstHEsLsQEsEsEE X X -CSNK2A1 CK2A1 P68400 human PhLP 64013 Q63737 Pdcl rat T19 448824 KLQYYYstsEDEDsD X -CSNK2A1 CK2A1 P68400 human SLC29A1 63959 Q9JIM1 Slc29a1 mouse S254 486282 ETkLDLIskGEEPKG Nucleoside_tran X -CSNK2A1 CK2A1 P68400 human EHMT2 10919 Q96KQ7 EHMT2 human S211 18009234 EIQHFRMsDDVHsLG X X -CSNK2A1 CK2A1 P68400 human 4E-BP1 1978 Q13541 EIF4EBP1 human S112 447526 KRAGGEEsQFEMDI_ eIF_4EBP X -CSNK2A1 CK2A1 P68400 human RANGAP1 5905 P46060 RANGAP1 human S358 458865 AKVLASLsDDEDEEE X X -CSNK2A1 CK2A1 P68400 human CD5 921 P06127 CD5 human S485 450128 QPDNssDsDyDLHGA X X -CSNK2A1 CK2A1 P68400 human eEF1B 100009286 P34826 EEF1B2 rabbit S106 452653 DDIDLFGsDDEEEsE EF-1_beta_acid X -CSNK2A1 CK2A1 P68400 human TNFAIP1 7126 Q13829 TNFAIP1 human S280 3195881 SRSQAsPsEDEEtFE X X -CSNK2A1 CK2A1 P68400 human SLC3A2 6520 P08195 SLC3A2 human S406 6003504 LLTssyLsDsGsTGE X -CSNK2A1 CK2A1 P68400 human RFC1 89809 D3ZFT1 Rfc1 rat S69 452680 KKRIIyDsDsESEET X -CSNK2A1 CK2A1 P68400 human CCNF 899 P41002 CCNF human S621 288031702 GYEGDQEsEGEKEGD X X -CSNK2A1 CK2A1 P68400 human ODC 24609 P09057 Odc1 rat S303 451283 VWKEQTGsDDEDESN Orn_DAP_Arg_deC X -CSNK2A1 CK2A1 P68400 human PACS2 23241 Q86VP3 PACS2 human S208 1884003502 EEYESFssEQEAsDD X X -CSNK2A1 CK2A1 P68400 human Sialoprotein-2 P13839 Ibsp rat S31 457538 RRIKAEDsEENGVFK BSP_II X -CSNK2A1 CK2A1 P68400 human ARNT 405 P27540 ARNT human S77 458309 DKERFARsDDEQssA X -CSNK2A1 CK2A1 P68400 human PTEN 5728 P60484 PTEN human S370 448649 TSVtPDVsDNEPDHy X X -CSNK2A1 CK2A1 P68400 human G6PD 2539 P11413 G6PD human T145 1883583400 FyLALPPtVyEAVTK X X -CSNK2A1 CK2A1 P68400 human adrenodoxin 281157 P00257 FDX1 cow T129 455475 FEKLEAItDEENDML Fer2 X -CSNK2A1 CK2A1 P68400 human FANCD2 2177 Q9BXW9 FANCD2 human S886 31867427 TSSsDtLsEEkNsEC FancD2 X X -CSNK2A1 CK2A1 P68400 human GJA8 395846 P36381 GJA8 chicken S364 465560 KAEEEVVsDEVEGPS X X -CSNK2A1 CK2A1 P68400 human NHE5 6553 Q14940 SLC9A5 human T714 20832302 EEsDssEtEKEDDEG X -CSNK2A1 CK2A1 P68400 human PhLP 5082 Q13371 PDCL human S20 448825 LQYyysssEDEDsDH X X -CSNK2A1 CK2A1 P68400 human PTEN 5728 P60484 PTEN human T383 448315 HyRYsDttDsDPENE X X 9554; 9549; 7960 -CSNK2A1 CK2A1 P68400 human TYMS 7298 P04818 TYMS human S124 13209303 FLDsLGFsTREEGDL Thymidylat_synt X -CSNK2A1 CK2A1 P68400 human CLTB 281698 P04975 CLTB cow S11 465605 DFGFFSSsEsGAPEA Clathrin_lg_ch X -CSNK2A1 CK2A1 P68400 human MRTO4 51154 Q9UKD2 MRTO4 human S233 14576313 AsEsTEEsDsEDDD_ X -CSNK2A1 CK2A1 P68400 human MCM2 4171 P49736 MCM2 human S40 452311 RRtDALtssPGRDLP X -CSNK2A1 CK2A1 P68400 human FTO 79068 Q9C0B1 FTO human T150 23108331 NDYLQIEtIQALEEL FTO_NTD X X -CSNK2A1 CK2A1 P68400 human RIC8A 293614 Q80ZG1 Ric8a rat S523 3213324 TMEGQLssDPDsDPD X -CSNK2A1 CK2A1 P68400 human DARPP-32 360616 Q6J4I0 Ppp1r1b rat S97 466340 LQTISNLsENQAsEE DARPP-32 X -CSNK2A1 CK2A1 P68400 human CD6 923 P30203 CD6 human S480 28095001 PPPEDSDsGsDsDYE X -CSNK2A1 CK2A1 P68400 human PSMD3 5709 O43242 PSMD3 human S6 18912808 __MkQEGsARRRGAD X -CSNK2A1 CK2A1 P68400 human Sialoprotein-2 P13839 Ibsp rat S76 457542 EENGDGDssEEEGEE BSP_II X -CSNK2A1 CK2A1 P68400 human CDH1 999 P12830 CDH1 human S847 465568 sEAAsLSsLNsSEsD CADH_Y-type_LIR X -CSNK2A1 CK2A1 P68400 human IRS1 25467 P35570 Irs1 rat S307 447558 TEsITATsPASMVGG X 2381 -CSNK2A1 CK2A1 P68400 human ABCA1 19 O95477 ABCA1 human T1242 452017 SSYGISEttLEEIFL X -CSNK2A1 CK2A1 P68400 human BIK 638 Q13323 BIK human T33 448350 TMEVLGMtDsEEDLD bcl-2I13 X -CSNK2A1 CK2A1 P68400 human PRPF3 9129 O43395 PRPF3 human T494 999610 TEAVQDPtKVEAHVR PRP3 X X -CSNK2A1 CK2A1 P68400 human STC2 8614 O76061 STC2 human S288 450097 AQGPSGssEWEDEQS X -CSNK2A1 CK2A1 P68400 human CETN2 1069 P41208 CETN2 human S158 34405001 RDGDGEVsEQEFLRI EF-hand_7 X -CSNK2A1 CK2A1 P68400 human RAD1 5810 O60671 RAD1 human S280 14881302 PDEEVPEsEs_____ X -CSNK2A1 CK2A1 P68400 human CREB3 10488 O43889 CREB3 human S46 1827354100 LPLSEVPsDWEVDDL X X -CSNK2A1 CK2A1 P68400 human NPM1 18148 Q61937 Npm1 mouse S125 459897 AVEEDAEsEDEDEED X -CSNK2A1 CK2A1 P68400 human TR-alpha iso5 21833 P63058_OBS Thra mouse S474 449309 ASSLSSSssDEDTEV X -CSNK2A1 CK2A1 P68400 human LASS6 253782 Q6ZMG9 CERS6 human S346 22350309 DRsDIEsssDEEDSE X -CSNK2A1 CK2A1 P68400 human CLTB 281698 P04975 CLTB cow S13 465606 GFFSSsEsGAPEAAE Clathrin_lg_ch X -CSNK2A1 CK2A1 P68400 human DDHD1 80821 Q8NEL9 DDHD1 human S104 465582 GSSLRYYsEGESGGG X -CSNK2A1 CK2A1 P68400 human KIR3DL1 3811 P43629 KIR3DL1 human S388 990303 RTANsEDsDEQDPEE X -CSNK2A1 CK2A1 P68400 human FGA 2243 P02671 FGA human S542 466009 PMLGEFVsETESRGs X -CSNK2A1 CK2A1 P68400 human N-Myc 4613 P04198 MYCN human S263 448221 GEDTLsDsDDEDDEE Myc_N X -CSNK2A1 CK2A1 P68400 human SGT1 11319 O95905 ECD human S505 3178824 PRPNEsDsDDLDDED SGT1 X -CSNK2A1 CK2A1 P68400 human TLE1 7088 Q04724 TLE1 human S253 23940705 DNLVVDVsNEDPSsP X -CSNK2A1 CK2A1 P68400 human FANCD2 2177 Q9BXW9 FANCD2 human S882 1871613600 DGSkTSSsDtLsEEk FancD2 X -CSNK2A1 CK2A1 P68400 human 14-3-3 gamma 22628 P61982 Ywhag mouse S235 14569218 DNLTLWTsDQQDDDG X -CSNK2A1 CK2A1 P68400 human RRAD 6236 P55042 RRAD human S299 457398 KMAFRAKsKsCHDLS X -CSNK2A1 CK2A1 P68400 human Huntingtin 3064 P42858 HTT human S16 12056100 kAFEsLksFQQQQQQ X -CSNK2A1 CK2A1 P68400 human p47phox 653361 P14598 NCF1 human S208 465580 KRGWIPAsFLEPLDS X -CSNK2A1 CK2A1 P68400 human DNAJB2 3300 P25686 DNAJB2 human S264 62382605 LAMAySLsEMEAAGK X -CSNK2A1 CK2A1 P68400 human COL17A1 1308 Q9UMD9 COL17A1 human S542 484006 LDKIGLHsDsQEELW X -CSNK2A1 CK2A1 P68400 human RIC8A 293614 Q80ZG1 Ric8a rat S527 3213327 QLssDPDsDPD____ X -CSNK2A1 CK2A1 P68400 human LSD1 23028 O60341 KDM1A human S131 453104 DEsLANLsEDEyysE X X 37177 -CSNK2A1 CK2A1 P68400 human Survivin 332 O15392 BIRC5 human T48 18451300 AGFIHCPtENEPDLA BIR X -CSNK2A1 CK2A1 P68400 human HMGA2 15364 P52927 Hmga2 mouse S100 4708612 AQETEEtssQEsAEE X -CSNK2A1 CK2A1 P68400 human G6PI 2821 P06744 GPI human S185 455279 GPRVWyVsNIDGTHI PGI X -CSNK2A1 CK2A1 P68400 human GCH1 2643 P30793 GCH1 human S81 487495 AYSSILSsLGENPQR GTP_cyclohydroI X -CSNK2A1 CK2A1 P68400 human MRE11A 4361 P49959 MRE11 human S649 455765 EVIEVDEsDVEEDIF X -CSNK2A1 CK2A1 P68400 human CLPH 64029 Q68FX6 Cabs1 rat T280 12658500 DNPEDPLtDEEPADG CABS1 X -CSNK2A1 CK2A1 P68400 human SRC-2 10499 Q15596 NCOA2 human S499 4728850 MsPGVAGsPrIPPSQ NCOA_u2 X -CSNK2A1 CK2A1 P68400 human FETUA 280988 P12763 AHSG cow S323 467424 SGVAsVEssSGEAFH X -CSNK2A1 CK2A1 P68400 human HDAC6 10013 Q9UBN7 HDAC6 human S458 18944908 EEDNVEEsEEEGPWE X -CSNK2A1 CK2A1 P68400 human CDC37 114562 Q63692 Cdc37 rat S13 450034 VWDHIEVsDDEDETH CDC37_N X 13248 -CSNK2A1 CK2A1 P68400 human TRHR 25570 Q01717 Trhr rat T365 465592 KEsDRFstELDDItV X -CSNK2A1 CK2A1 P68400 human SPTBN1 6711 Q01082 SPTBN1 human T2159 471399 NGAtEQRtssKEssP X -CSNK2A1 CK2A1 P68400 human TAT-SF1 27336 O43719 HTATSF1 human S748 18016601 GSsFILssDDDDDDI X X -CSNK2A1 CK2A1 P68400 human CHD-4 1108 Q14839 CHD4 human S308 471447 FGskRKRsssEDDDL X -CSNK2A1 CK2A1 P68400 human MAX 4149 P61244 MAX human S11 449308 NDDIEVEsDEEQPRF X -CSNK2A1 CK2A1 P68400 human RPS5 20103 P97461 Rps5 mouse S24 9819906 IkLFGkWsTDDVQIN X -CSNK2A1 CK2A1 P68400 human RPAP3 79657 Q9H6T3 RPAP3 human S121 1279825 sLsQEsEsEEdGIHV X X -CSNK2A1 CK2A1 P68400 human PSEN2 5664 P49810 PSEN2 human S335 449963 YDsFGEPsYPEVFEP Presenilin X -CSNK2A1 CK2A1 P68400 human TSPY1 7258 Q01534 TSPY1 human T300 460704 PPEEGTEtSGDSQLL X -CSNK2A1 CK2A1 P68400 human DTD1 92675 Q8TEA8 DTD1 human S181 36396300 RAKGPsEssKERNtP X -CSNK2A1 CK2A1 P68400 human PKD2 5311 Q13563 PKD2 human S812 451598 FPRsLDDsEEDDDED X -CSNK2A1 CK2A1 P68400 human MCM2 4171 P49736 MCM2 human S53 473058 LPPFEDEsEGLLGtE MCM2_N X -CSNK2A1 CK2A1 P68400 human HSP90B 3326 P08238 HSP90AB1 human S255 449266 PKIEDVGsDEEDDsG HSP90 X X -CSNK2A1 CK2A1 P68400 human CDC25C 995 P30307 CDC25C human T236 451436 VEKFkDNtIPDkVKK M-inducer_phosp X X -CSNK2A1 CK2A1 P68400 human PML 5371 P29590 PML human S560 6835504 EERVVVIsssEDsDA DUF3583 X -CSNK2A1 CK2A1 P68400 human DDHD1 338047 O46606 DDHD1 cow S93 465581 SDDNYDFsSAESGSS X -CSNK2A1 CK2A1 P68400 human PER2 8864 O15055 PER2 human S696 468399 EMVEDAAsGPEsLDC X X -CSNK2A1 CK2A1 P68400 human ER-alpha 2099 P03372 ESR1 human S559 6048400 PTsRGGAsVEETDQS ESR1_C X X -CSNK2A1 CK2A1 P68400 human NCL 25135 P13383 Ncl rat S34 466005 DsEDEEMsEDEDDss X -CSNK2A1 CK2A1 P68400 human HDAC1 3065 Q13547 HDAC1 human S423 447913 CEEEFsDsEEEGEGG X X -CSNK2A1 CK2A1 P68400 human MRE11A 4361 P49959 MRE11 human S689 452321 KGVDFEssEDDDDDP X X -CSNK2A1 CK2A1 P68400 human ARRB2 iso2 281638 P32120-2 ARRB2 cow T382 455373 EFETNYAtDDDIVFE X -CSNK2A1 CK2A1 P68400 human G3BP-1 10146 Q13283 G3BP1 human S149 449041 VtEPQEEsEEEVEEP X X -CSNK2A1 CK2A1 P68400 human MYH10 4628 P35580 MYH10 human S1975 465603 NEtQPPQsE______ X -CSNK2A1 CK2A1 P68400 human CDH1 12550 P09803 Cdh1 mouse S848 15754601 GsEAAsLssLNSsEs CADH_Y-type_LIR X -CSNK2A1 CK2A1 P68400 human CTDP1 9150 Q9Y5B0 CTDP1 human S944 455467 NEDEGsssEADEMAK FCP1_C X -CSNK2A1 CK2A1 P68400 human XPC 7508 Q01831 XPC human S129 14161729 sNEEEEEsENDWEEV X -CSNK2A1 CK2A1 P68400 human MCM2 4171 P49736 MCM2 human S139 454180 RRGLLyDsDEEDEER MCM2_N X 8861; 12958 -CSNK2A1 CK2A1 P68400 human Myf-5 4617 P13349 MYF5 human S49 457384 HKAELQGsDEDEHVR Basic X -CSNK2A1 CK2A1 P68400 human PER2 8864 O15055 PER2 human S700 468400 DAAsGPEsLDCLAGP X -CSNK2A1 CK2A1 P68400 human HDAC1 3065 Q13547 HDAC1 human S421 447912 IACEEEFsDsEEEGE X X -CSNK2A1 CK2A1 P68400 human FURIN 5045 P09958 FURIN human S773 469742 AWQEECPsDsEEDEG X -CSNK2A1 CK2A1 P68400 human TEBP 10728 Q15185 PTGES3 human S113 451129 WKDWEDDsDEDMsNF X X -CSNK2A1 CK2A1 P68400 human DTD1 92675 Q8TEA8 DTD1 human S197 1983955 KEDRsAssGAEGDVs X -CSNK2A1 CK2A1 P68400 human HS1 3059 P14317 HCLS1 human T23 11349501 tQGDDWDtDPDFVND X -CSNK2A1 CK2A1 P68400 human NPHP1 4867 O15259 NPHP1 human S123 26395107 EEEEEsEsEDsEDSG X X -CSNK2A1 CK2A1 P68400 human DARPP-32 360616 Q6J4I0 Ppp1r1b rat S102 457675 NLsENQAsEEEDELG DARPP-32 X 3401 -CSNK2A1 CK2A1 P68400 human Sialoprotein-2 281233 Q28862 IBSP cow S300 457546 YKGRGYDsYDGQDYY BSP_II X -CSNK2A1 CK2A1 P68400 human MDM2 4193 Q00987 MDM2 human S269 455458 sEEGQELsDEDDEVy X -CSNK2A1 CK2A1 P68400 human KIR3DL1 3811 P43629 KIR3DL1 human S385 990304 AGNRTANsEDsDEQD X -CSNK2A1 CK2A1 P68400 human DAXX 1616 Q9UER7 DAXX human S739 467727 EIIVLsDsD______ X X -CSNK2A1 CK2A1 P68400 human FNIP1 96459 Q8TF40 FNIP1 human S938 1861699800 WDIPRNEssDsALGD X -CSNK2A1 CK2A1 P68400 human MSK1 9252 O75582 RPS6KA5 human T793 12159000 ADSNNPEtLFQFSDS X -CSNK2A1 CK2A1 P68400 human hnRNP A1 3178 P09651 HNRNPA1 human S199 451555 sQrGrsGsGNFGGGr X -CSNK2A1 CK2A1 P68400 human SRC-2 10499 Q15596 NCOA2 human S487 4728845 GQPTSMLsPrHRMsP NCOA_u2 X -CSNK2A1 CK2A1 P68400 human GRB14 2888 Q14449 GRB14 human S366 29576856 GCSsQSIsPMRsIsE X -CSNK2A1 CK2A1 P68400 human PTEN 5728 P60484 PTEN human T382 448314 DHyRYsDttDsDPEN X X 9554; 9549; 7960 -CSNK2A1 CK2A1 P68400 human Myc 4609 P01106 MYC human S362 466010 RKCtsPrssDtEENV X -CSNK2A1 CK2A1 P68400 human NCAPG 64151 Q9BPX3 NCAPG human S973 3210609 CQtAEADsEsDHEVP X -CSNK2A1 CK2A1 P68400 human CAPZA1 829 P52907 CAPZA1 human S9 457555 ADFDDrVsDEEkVRI X X -CSNK2A1 CK2A1 P68400 human hnRNP C1/C2 3183 P07910 HNRNPC human S260 448833 sEGGADDsAEEGDLL X -CSNK2A1 CK2A1 P68400 human USP7 7874 Q93009 USP7 human S18 449238 KAGEQQLsEPEDMEM X X -CSNK2A1 CK2A1 P68400 human NRL 4901 P54845 NRL human S117 1880112600 PHGYYPGsPEETGAQ X -CSNK2A1 CK2A1 P68400 human Sialoprotein-2 281233 Q28862 IBSP cow S75 457542 EENGNGDssEEEEEE BSP_II X -CSNK2A1 CK2A1 P68400 human SEC63 11231 Q9UGP8 SEC63 human S576 27440600 VsDKGsDsEEEETNR X X -CSNK2A1 CK2A1 P68400 human LASS6 253782 Q6ZMG9 CERS6 human S345 22350306 DDRsDIEsssDEEDS X -CSNK2A1 CK2A1 P68400 human CPLX1 768228 Q0IIL7 CPLX1 cow S115 474557 AAEEEDEsILDTVIK Synaphin X -CSNK2A1 CK2A1 P68400 human TELO2 9894 Q9Y4R8 TELO2 human S485 27530803 PQAQLAGsDsDLDsD X X -CSNK2A1 CK2A1 P68400 human TTI1 9675 O43156 TTI1 human S828 9765114 DVADGNVsDFDNEEE X X -CSNK2A1 CK2A1 P68400 human CREB 1385 P16220 CREB1 human S94 451807 QISTIAEsEDsQEsV X -CSNK2A1 CK2A1 P68400 human CFTR 12638 P26361 Cftr mouse T1467 21440502 ITALKEEtEEEVQET X -CSNK2A1 CK2A1 P68400 human SET iso2 6418 Q01105-2 SET human S9 6308300 sAPAAkVsKkELNsN X -CSNK2A1 CK2A1 P68400 human MSK1 9252 O75582 RPS6KA5 human S759 12159003 sTETRssssESSHSs X -CSNK2A1 CK2A1 P68400 human OTUD5 55593 Q96G74 OTUD5 human S177 449291 EVGAGyNsEDEyEAA X -CSNK2A1 CK2A1 P68400 human FNIP1 96459 Q8TF40 FNIP1 human S948 4734337 sALGDsEsEDTGHDM X -CSNK2A1 CK2A1 P68400 human FN1 iso1 2335 P02751-1 FN1 human S2384 467903 VQADREDsRE_____ X -CSNK2A1 CK2A1 P68400 human CFTR 1080 P13569 CFTR human S422 3333404 NNNNRktsNGDDsLF X X -CSNK2A1 CK2A1 P68400 human FANCD2 2177 Q9BXW9 FANCD2 human T884 1871613603 SkTSSsDtLsEEkNs FancD2 X -CSNK2A1 CK2A1 P68400 human CDC25B 994 P30305 CDC25B human S186 448746 EAGsGAAsssGEDkE M-inducer_phosp X -CSNK2A1 CK2A1 P68400 human occludin 100506658 Q16625 OCLN human S408 2906719 DyttGGEsCDELEED X X -CSNK2A1 CK2A1 P68400 human DOK7 231134 Q18PE0 Dok7 mouse S265 41621602 GDDRSLsssSSEASH X -CSNK2A1 CK2A1 P68400 human MCM2 4171 P49736 MCM2 human S27 452310 GNDPLtssPGRssRR X -CSNK2A1 CK2A1 P68400 human SIRT1 93759 Q923E4 Sirt1 mouse S683 9993600 EEPLEDEsEIEEFYN X X -CSNK2A1 CK2A1 P68400 human PEDF 5176 P36955 SERPINF1 human S114 455232 ALYYDLIsSPDIHGT Serpin X -CSNK2A1 CK2A1 P68400 human LASS5 91012 Q8N5B7 CERS5 human S355 18260885 DRsDVEsssEEEDVT X -CSNK2A1 CK2A1 P68400 human HOXB7 3217 P09629 HOXB7 human S132 465569 RIYPWMRssGTDRKR X -CSNK2A1 CK2A1 P68400 human WAVE2 10163 Q9Y6W5 WASF2 human S489 6377640 sDsEDDssEFDEDDW X -CSNK2A1 CK2A1 P68400 human CREB iso1 81646 P15337-1 Creb1 rat S108 451807 QISTIAEsEDsQEsV X -CSNK2A1 CK2A1 P68400 human TOP2A 7153 P11388 TOP2A human S1365 18016961 TKtsPKLsNkELKPQ X -CSNK2A1 CK2A1 P68400 human Sialoprotein-2 281233 Q28862 IBSP cow S31 457538 RRAKLEDsEENGVFK BSP_II X -CSNK2A1 CK2A1 P68400 human FANCD2 2177 Q9BXW9 FANCD2 human T896 27448950 kNsECDPtPsHRGQL FancD2 X X -CSNK2A1 CK2A1 P68400 human Myc 4609 P01106 MYC human S363 466011 KCtsPrssDtEENVk X -CSNK2A1 CK2A1 P68400 human p53 7157 P04637 TP53 human S149 456326 PVQLWVDstPPPGtR P53 X -CSNK2A1 CK2A1 P68400 human NFkB-p65 19697 Q04207 Rela mouse S527 447799 SGLPNGLsGDEDFss X X -CSNK2A1 CK2A1 P68400 human TR-alpha iso5 21833 P63058_OBS Thra mouse S475 449310 SSLSSSssDEDTEVF X -CSNK2A1 CK2A1 P68400 human VDR 7421 P11473 VDR human S208 456982 SFSNLDLsEEDSDDP X X -CSNK2A1 CK2A1 P68400 human VHL 7428 P40337 VHL human S38 15573200 EEsGAEEsGPEEsGP X -CSNK2A1 CK2A1 P68400 human Wee1 7465 P30291 WEE1 human S121 456468 WEEEGFGsSsPVKsP X -CSNK2A1 CK2A1 P68400 human p53 7157 P04637 TP53 human T55 450685 DDIEQWFtEDPGPDE TAD2 X -CSNK2A1 CK2A1 P68400 human occludin 100506658 Q16625 OCLN human T400 471470 tEQDHyEtDyttGGE X X -CSNK2A1 CK2A1 P68400 human IkB-alpha 4792 P25963 NFKBIA human T299 456335 EsEFTEFtEDELPyD X -CSNK2A1 CK2A1 P68400 human Ikaros 22778 Q03267 Ikzf1 mouse S63 451348 NVkVETQsDEENGRA X -CSNK2A1 CK2A1 P68400 human DTD1 92675 Q8TEA8 DTD1 human S179 23112003 KTRAKGPsEssKERN X -CSNK2A1 CK2A1 P68400 human BMAL1 11865 Q9WTL8 Bmal1 mouse S97 7359500 RRRDKMNsFIDELAS HLH X -CSNK2A1 CK2A1 P68400 human SLC18A2 25549 Q01827 Slc18a2 rat S512 465595 PIGDDEEsEsD____ X -CSNK2A1 CK2A1 P68400 human CETN1 1068 Q12798 CETN1 human T138 34405000 NELGENLtDEELQEM EF-hand_7 X -CSNK2A1 CK2A1 P68400 human PSMA3 29670 P18422 Psma3 rat S243 451184 AEkyAKEsLKEEDEs X -CSNK2A1 CK2A1 P68400 human TOP2A 7153 P11388 TOP2A human S1377 448765 KPQKsVVsDLEADDV X -CSNK2A1 CK2A1 P68400 human TIF1A 54700 Q9NYV6 RRN3 human S172 470002 GDVDVsDsDDEDDNL RRN3 X X -CSNK2A1 CK2A1 P68400 human LDLR 281276 P01131 LDLR cow S258 465609 YPSRQMVsLEDDVA_ X -CSNK2A1 CK2A1 P68400 human CDC34 997 P49427 CDC34 human S236 448690 DDsGtEEs_______ X X -CSNK2A1 CK2A1 P68400 human CK2A1 1457 P68400 CSNK2A1 human Y182 10294400 DWGLAEFyHPGQEYN Pkinase X -CSNK2A1 CK2A1 P68400 human SSRP1 6749 Q08945 SSRP1 human S657 456295 KSssRQLsEsFksKE X -CSNK2A1 CK2A1 P68400 human CDK1 983 P06493 CDK1 human S39 455465 MkkIRLEsEEEGVPs Pkinase X X -CSNK2A1 CK2A1 P68400 human FosB 2354 P53539 FOSB human S27 465535 SAESQYLsSVDSFGS X X -CSNK2A1 CK2A1 P68400 human FETUA 280988 P12763 AHSG cow S324 471394 GVAsVEssSGEAFHV X -CSNK2A1 CK2A1 P68400 human DLG3 58948 Q62936 Dlg3 rat S632 4710993 KGVTSNTsDSESSSK X -CSNK2A1 CK2A1 P68400 human Caldesmon 373965 P12957 CALD1 chicken S73 457422 SEVNAQNsVAEEETK Caldesmon X -CSNK2A1 CK2A1 P68400 human FNIP1 96459 Q8TF40 FNIP1 human S941 4734327 PRNEssDsALGDsEs X -CSNK2A1 CK2A1 P68400 human p70S6K 83840 P67999 Rps6kb1 rat S40 450117 DQPEDAGsEDELEEG X -CSNK2A1 CK2A1 P68400 human IkB-alpha 4792 P25963 NFKBIA human S32 448203 LLDDRHDsGLDsMkD X 5210; 2859; 9246; 5209 -CSNK2A1 CK2A1 P68400 human ATF-1 466 P18846 ATF1 human S51 15725602 SSDsIGssQKAHGIL pKID X -CSNK2A1 CK2A1 P68400 human CK2B 1460 P67870 CSNK2B human S2 447646 ______MsssEEVsW X -CSNK2A1 CK2A1 P68400 human EVI1 2122 Q03112 MECOM human S726 4703001 PLkMEPQsPGEVKKL X X -CSNK2A1 CK2A1 P68400 human GBF1 8729 Q92538 GBF1 human S292 1170755600 VVSPSTDsGLEFsSQ X X -CSNK2A1 CK2A1 P68400 human Ikaros 22778 Q03267 Ikzf1 mouse S13 4828300 GQDMSQVsGKESPPV X -CSNK2A1 CK2A1 P68400 human Ikaros 22778 Q03267 Ikzf1 mouse T393 451353 sNsCQDstDtEsNAE X -CSNK2A1 CK2A1 P68400 human DDHD1 338047 O46606 DDHD1 cow S105 465582 GSSLRYYsEGESGGG X -CSNK2A1 CK2A1 P68400 human SLC3A2 6520 P08195 SLC3A2 human S531 6003501 RRLsDQRsKERSLLH X -CSNK2A1 CK2A1 P68400 human TRHR 25570 Q01717 Trhr rat T371 465593 stELDDItVTDtYVs X -CSNK2A1 CK2A1 P68400 human ARRB2 216869 Q91YI4 Arrb2 mouse T383 455373 EFDTNYAtDDDIVFE X X -CSNK2A1 CK2A1 P68400 human PACSIN1 23969 Q61644 Pacsin1 mouse S358 4730500 QTYATEWsDDEsGNP X -CSNK2A1 CK2A1 P68400 human DTD1 92675 Q8TEA8 DTD1 human S182 36396301 AKGPsEssKERNtPR X -CSNK2A1 CK2A1 P68400 human MLH1 4292 P40692 MLH1 human S477 480003 RKRHREDsDVEMVED X X -CSNK2A1 CK2A1 P68400 human SERINC3 10955 Q13530 SERINC3 human S383 1255792400 DTTTsGAsDEEDGQP Serinc X X -CSNK2A1 CK2A1 P68400 human FGA 2243 P02671 FGA human S609 466008 KMADEAGsEADHEGt X -CSNK2A1 CK2A1 P68400 human PR 5241 P06401 PGR human S81 450160 TQDQQsLsDVEGAys Prog_receptor X X -CSNK2A1 CK2A1 P68400 human LASS5 91012 Q8N5B7 CERS5 human S354 18260882 DDRsDVEsssEEEDV X -CSNK2A1 CK2A1 P68400 human SNCA 6622 P37840 SNCA human S129 448278 NEAyEMPsEEGyQDy Synuclein X X 23706; 87281 -CSNK2A1 CK2A1 P68400 human FETUA 280988 P12763 AHSG cow S320 467423 HTFSGVAsVEssSGE X -CSNK2A1 CK2A1 P68400 human PDCD5 9141 O14737 PDCD5 human S119 452536 NRRKVMDsDEDDDy_ X X -CSNK2A1 CK2A1 P68400 human CREB iso1 81646 P15337-1 Creb1 rat S142 448547 RkILNDLssDAPGVP pKID X -CSNK2A1 CK2A1 P68400 human IGFBP1 3484 P08833 IGFBP1 human S194 451660 LAKAQETsGEEIsKF Thyroglobulin_1 X X -CSNK2A1 CK2A1 P68400 human factor V 2153 P12259 F5 human S720 451408 LEPEDEEsDADYDYQ X -CSNK2A1 CK2A1 P68400 human SLC3A2 6520 P08195 SLC3A2 human S410 6003502 syLsDsGsTGEHTkS X -CSNK2A1 CK2A1 P68400 human MSK1 9252 O75582 RPS6KA5 human S758 455798 tsTETRssssESSHS X -CSNK2A1 CK2A1 P68400 human DNMT3A 1788 Q9Y6K1 DNMT3A human S393 17548182 VCHDsDEsDTAKAVE X X -CSNK2A1 CK2A1 P68400 human SAT 6303 P21673 SAT1 human S149 11390101 RRGAsDLsSEEGWRL X -CSNK2A1 CK2A1 P68400 human IkB-beta 4793 Q15653 NFKBIB human S315 452014 sGPCSsSsDSDSGDE X -CSNK2A1 CK2A1 P68400 human MSK2 8986 O75676 RPS6KA4 human S324 11489900 PFRPQIRsELDVGNF Pkinase_C X -CSNK2A1 CK2A1 P68400 human B-Myb 4605 P10244 MYBL2 human T18 465554 DELHyQDtDsDVPEQ X -CSNK2A1 CK2A1 P68400 human LIG1 3978 P18858 LIG1 human S66 448498 KAARVLGsEGEEEDE X -CSNK2A1 CK2A1 P68400 human TEBP 10728 Q15185 PTGES3 human S118 451130 DDsDEDMsNFDRFsE X X -CSNK2A1 CK2A1 P68400 human AP-2 alpha 7020 P05549 TFAP2A human S429 20797701 TDNNAKssDKEEKHR X X -CSNK2A1 CK2A1 P68400 human CTDP1 9150 Q9Y5B0 CTDP1 human S740 453872 TkAQRENsPAAFPDR FCP1_C X -CSNK2A1 CK2A1 P68400 human eIF2-beta 8894 P20042 EIF2S2 human S67 450072 DTRKkDAsDDLDDLN X X -CSNK2A1 CK2A1 P68400 human RAD1 5810 O60671 RAD1 human S282 14881301 EEVPEsEs_______ X -CSNK2A1 CK2A1 P68400 human RGS19 10287 P49795 RGS19 human S24 449957 ADRPPSMsSHDTASP X -CSNK2A1 CK2A1 P68400 human LXR-alpha 10062 Q13133 NR1H3 human S198 469114 SLPPRASsPPQILPQ X X -CSNK2A1 CK2A1 P68400 human ACE2 59272 Q9BYF1 ACE2 human S787 1868161400 PyAsIDIsKGENNPG X -CSNK2A1 CK2A1 P68400 human eIF4G iso8 1981 Q04637-8 EIF4G1 human S1239 18910225 sPLKAALsEEELEKK X X -CSNK2A1 CK2A1 P68400 human CHD-4 1108 Q14839 CHD4 human S428 470519 WEAKEDNsEGEEILE X -CSNK2A1 CK2A1 P68400 human PML 5371 P29590 PML human S561 6835503 ERVVVIsssEDsDAE DUF3583 X -CSNK2A1 CK2A1 P68400 human C/EBP-beta 24253 P21272 Cebpb rat S223 408589401 kkAVDKLsDEYKMRR bZIP_2 X -CSNK2A1 CK2A1 P68400 human SRC-2 10499 Q15596 NCOA2 human S469 4728825 NYALKMNsPsQSsPG NCOA_u2 X -CSNK2A1 CK2A1 P68400 human MED17 234959 Q8VCD5 Med17 mouse S53 4765330 RIDFSQGsGsEEEEA X X -CSNK2A1 CK2A1 P68400 human SRF 6722 P11831 SRF human S77 451802 PTAGALYsGsEGDsE X -CSNK2A1 CK2A1 P68400 human PML 5371 P29590 PML human S562 6835502 RVVVIsssEDsDAEN DUF3583 X -CSNK2A1 CK2A1 P68400 human CLOCK 9575 O15516 CLOCK human S106 1881001400 DWKPTFLsNEEFTQL X X -CSNK2A1 CK2A1 P68400 human PhLP 64013 Q63737 Pdcl rat S20 448825 LQYYYstsEDEDsDH X -CSNK2A1 CK2A1 P68400 human PIK3R1 5295 P27986 PIK3R1 human S608 448133 ENtEDQysLVEDDED X -CSNK2A1 CK2A1 P68400 human TOP1 7150 P11387 TOP1 human S10 465604 GDHLHNDsQIEADFR X -CSNK2A1 CK2A1 P68400 human Sialoprotein-2 P13839 Ibsp rat S77 457543 ENGDGDssEEEGEEE BSP_II X -CSNK2A1 CK2A1 P68400 human Geminin 51053 O75496 GMNN human S184 25535401 EEETVEDsLVEDSEI Geminin X -CSNK2A1 CK2A1 P68400 human CD5 921 P06127 CD5 human S483 450127 sMQPDNssDsDyDLH X X -VRK2 VRK2 iso2 Q86Y07-2 human p53 22059 P02340 Tp53 mouse S18 447490 IsLELPLsQEtFsGL P53_TAD X 9284; 9286; 12571; 56979 -VRK2 VRK2 iso2 Q86Y07-2 human p53 22059 P02340 Tp53 mouse T21 447541 ELPLsQEtFsGLWKL P53_TAD X X -AURKA AurA O14965 human syntenin 6386 O00560 SDCBP human T200 1869341900 RPFERTItMHKDSTG PDZ; Peptidase_M50 X X -AURKA AurA O14965 human CRMP-1 1400 Q14194 CRMP1 human T101 11539300 RAALVGGttMIIDHV Amidohydro_1 X -AURKA AurA O14965 human WDR62 284403 O43379 WDR62 human S49 3175148 LRRRtRLstAsEEtV X -AURKA AurA O14965 human FAF1 11124 Q9UNN5 FAF1 human S291 450287 DVHMVsDsDGDDFED X X -AURKA AurA O14965 human WDR62 284403 O43379 WDR62 human T50 1246205 RRRtRLstAsEEtVQ X -AURKA AurA O14965 human TPX2 398174 Q6NUF4 tpx2.L frog S48 457642 PPDQRRLsETSVNTE Aurora-A_bind X -AURKA AurA O14965 human AurA 6790 O14965 AURKA human S67 457664 QAQkLVssHkPVQNQ X -AURKA AurA O14965 human SECISBP2L 9728 Q93073 SECISBP2L human T573 1868832803 IAKLKRPtALKKVIL X X -AURKA AurA O14965 human AurA 6790 O14965 AURKA human T287 457654 HAPSsRRttLCGtLD Pkinase X -AURKA AurA O14965 human ATP6V1A 11964 P50516 Atp6v1a mouse S175 14913505 LPPRNRGsVTYIAPP ATP-synt_ab_Xtn X X -AURKA AurA O14965 human ARPC1B 10095 O15143 ARPC1B human T21 10349703 HAWNkDRtQIAICPN X -AURKA AurA O14965 human NuMA-1 4926 Q14980 NUMA1 human S1887 3196640 tRssARRsQAGVsSG X -AURKA AurA O14965 human MCRS1 10445 Q96EZ8 MCRS1 human S36 40268168 AGQkRAssQALGTIP X X -AURKA AurA O14965 human SPAG5 10615 Q96R06 SPAG5 human S115 34824800 IsStPkTsEEAVDPL X X -AURKA AurA O14965 human dynactin 1 1639 Q14203 DCTN1 human S19 455515 TPSGSrMsAEAsArP X -AURKA AurA O14965 human AML2 864 Q13761 RUNX3 human T14 4733089 PSTSRRFtPPsPAFP X -AURKA AurA O14965 human ALDH1A1 216 P00352 ALDH1A1 human T493 63070900 yTEVkTVtVkISQKN X X -AURKA AurA O14965 human YAP1 10413 P46937 YAP1 human S397 3190672 tyHSRDEstDsGLsM X X -AURKA AurA O14965 human AurA 6790 O14965 AURKA human Y148 457653 kGkFGNVyLAREKQS Pkinase X -AURKA AurA O14965 human PRMT5 10419 O14744 PRMT5 human S103 1881955602 VEKIRRNsEAAMLQE X X -AURKA AurA O14965 human AurA 6790 O14965 AURKA human S266 457669 PENLLLGsAGELKIA Pkinase X -AURKA AurA O14965 human ARHGEF2 9181 Q92974 ARHGEF2 human S886 451365 PVDPRRRsLPAGDAL X X -AURKA AurA O14965 human FAF1 11124 Q9UNN5 FAF1 human S289 450286 ITDVHMVsDsDGDDF X X -AURKA AurA O14965 human AurA 6790 O14965 AURKA human S278 457670 KIADFGWsVHAPSsR Pkinase X -AURKA AurA O14965 human SPIN1 10927 Q9Y657 SPIN1 human S124 3217695 RVAtSRIsDAHLADt X X -AURKA AurA O14965 human WDR62 284403 O43379 WDR62 human S33 453570 PARRGQssPPPAPPI X -AURKA AurA O14965 human BRCA1 672 P38398 BRCA1 human S308 451604 KAEFCNKskQPGLAR X X -AURKA AurA O14965 human SKI 6497 P12755 SKI human S383 11145003 LsAFRPWsPAVSASE X -AURKA AurA O14965 human CRMP-1 1400 Q14194 CRMP1 human T102 11539301 AALVGGttMIIDHVV Amidohydro_1 X -AURKA AurA O14965 human LDH-B 3945 P07195 LDHB human S162 31882222 PkHrVIGsGCNLDsA X X -AURKA AurA O14965 human PAX8 7849 Q06710 PAX8 human S209 1877752105 DQDSCRLsIDSQSSS X -AURKA AurA O14965 human KIF2C 380006 Q91636 kif2c frog S719 3545002 LQVEEQAsKQISKKK X -AURKA AurA O14965 human MYBBP1A 10514 Q9BQG0 MYBBP1A human S1303 3210687 ARKKARLsLVIRsPs X -AURKA AurA O14965 human GSK3B 2932 P49841 GSK3B human S9 449111 SGRPRttsFAEsCkP X X 9336; 9331; 9327; 9323; 9322; 9325; 5558; 8566; 79774; 8466; 25462; 14026; 14332; 14310; 14630 -AURKA AurA O14965 human PHLDA1 22822 Q8WV24 PHLDA1 human S95 22459800 PLCLLRVsLLCALRA X -AURKA AurA O14965 human CENPJ 55835 Q9HC77 CENPJ human S467 31855585 LKCSNRksLsPsGLK X X -AURKA AurA O14965 human CETN2 1069 P41208 CETN2 human S170 448199 LRIMkKTsLY_____ X X -AURKA AurA O14965 human KIF4A 24137 O95239 KIF4A human T799 479906 PPKLRRRtFsLTEVR X X -AURKA AurA O14965 human CPEB 12877 P70166 Cpeb1 mouse T171 449610 VRGSRLDtRPILDsR CEBP1_N X -AURKA AurA O14965 human HAUS8 93323 Q9BT25 HAUS8 human S20 20583301 ATGPTNsssAKKKDK X X -AURKA AurA O14965 human PAX8 7849 Q06710 PAX8 human T277 1877752106 TLDDGkAtLTPSNTP X -AURKA AurA O14965 human NuMA-1 4926 Q14980 NUMA1 human T1811 1245323 tRsARRRttQIINIt X -AURKA AurA O14965 human VHL 7428 P40337 VHL human S72 469117 SVNsREPsQVIFCNr VHL X X -AURKA AurA O14965 human LIMK2 3985 P53671 LIMK2 human T494 467206 kATTKKRtLRKNDRK PK_Tyr_Ser-Thr X X -AURKA AurA O14965 human PAR3-alpha 56288 Q8TEW0 PARD3 human S962 11279402 SSRsGREsVSTAsDQ X X -AURKA AurA O14965 human TPX2 398174 Q6NUF4 tpx2.L frog S90 459997 KSQSKRSsRRMsKKH X -AURKA AurA O14965 human NEDD1 121441 Q8NHV4 NEDD1 human S405 4706050 FDDtGKssLGDMFsP X X -AURKA AurA O14965 human AurA 6790 O14965 AURKA human S226 457668 YRELQKLskFDEQRT Pkinase X -AURKA AurA O14965 human NDEL1 83431 Q9ERR1 Ndel1 mouse S251 474509 LtPSARIsALNIVGD NUDE_C X X -AURKA AurA O14965 human PLK1 5347 P53350 PLK1 human T210 448139 YDGERKktLCGtPNy Pkinase X X 4354; 5472; 9062 -AURKA AurA O14965 human ER-alpha 2099 P03372 ESR1 human S167 448102 GGRERLAsTNDkGSM Oest_recep X X 64508; 42101 -AURKA AurA O14965 human NPM1 4869 P06748 NPM1 human S125 459897 AVEEDAEsEDEEEED X X -AURKA AurA O14965 human DLG7 9787 Q15398 DLGAP5 human S627 456345 VKLFsGLsVssEGPs X -AURKA AurA O14965 human AurA 6790 O14965 AURKA human T16 457662 IsGPVkAtAPVGGPk X -AURKA AurA O14965 human FADD 8772 Q13158 FADD human S203 22496704 MsWNsDAsTSEAS__ X X -AURKA AurA O14965 human LATS2 26524 Q9NRM7 LATS2 human S83 451703 ALREIRysLLPFANE X X -AURKA AurA O14965 human SKI 6497 P12755 SKI human S326 41656200 RRVPRVssEPPASIR X -AURKA AurA O14965 human p73 7161 O15350 TP73 human S235 23481800 DPVTGRQsVVVPYEP P53 X X -AURKA AurA O14965 human AurA 6790 O14965 AURKA human S10 457661 RsKENCIsGPVkAtA X -AURKA AurA O14965 human HEC1 10403 O14777 NDC80 human S44 474539 kPtFGkLsINkPtsE X -AURKA AurA O14965 human MCRS1 10445 Q96EZ8 MCRS1 human S35 14575930 LAGQkRAssQALGTI X X -AURKA AurA O14965 human NuMA-1 4926 Q14980 NUMA1 human S2047 4748253 kQADRRQsMAFsILN X -AURKA AurA O14965 human MBD3 53615 O95983 MBD3 human S85 1210518 RQRVRyDssNQVKGk MBDa X X -AURKA AurA O14965 human CtIP 5932 Q99708 RBBP8 human S593 4766307 IPLRPREsLETENVL X X -AURKA AurA O14965 human H3 8350 P68431 H3C1 human S10 455676 tkQtArkstGGkAPr Histone X X 9701; 9711; 9606; 3465; 3642; 3377; 3475; 3458; 5764; 47398; 8481; 8552; 53348; 29237; 66065; 43185; 64522; 52725 -AURKA AurA O14965 human CtIP 5932 Q99708 RBBP8 human S327 452473 ELPtRVssPVFGATS X -AURKA AurA O14965 human MAP9 79884 Q49MG5 MAP9 human S625 999603 RKQKKRHsFLESEAL X X -AURKA AurA O14965 human CPEB 12877 P70166 Cpeb1 mouse S177 483983 DtRPILDsRSSsPSD CEBP1_N X -AURKA AurA O14965 human SIRT1 23411 Q96EB6 SIRT1 human T344 25594500 GkLLRNYtQNIDTLE SIR2 X X -AURKA AurA O14965 human SPIN1 10927 Q9Y657 SPIN1 human S109 24976101 LNkDERVsALEVLPD X X -AURKA AurA O14965 human PSEN2 5664 P49810 PSEN2 human S19 449962 EVCDERTsLMsAEsP X -AURKA AurA O14965 human KCTD12 115207 Q96CX2 KCTD12 human S243 18011104 ITVCGKTsLAkEVFG X -AURKA AurA O14965 human NuMA-1 4926 Q14980 NUMA1 human S1883 31033004 YrPttRssARRsQAG X -AURKA AurA O14965 human ALDH1A1 216 P00352 ALDH1A1 human T442 63070901 kDIDKAItISSALQA Aldedh X X -AURKA AurA O14965 human AurA 6790 O14965 AURKA human S41 457663 QNPLPVNsGQAQRVL X -AURKA AurA O14965 human BIM 10018 O43521 BCL2L11 human S98 8080218 RSssGyFsFDTDRsP X X -AURKA AurA O14965 human syntenin 6386 O00560 SDCBP human S131 56649728 kIGLRLKsIDNGIFV PDZ; Peptidase_M50 X X -AURKA AurA O14965 human IkB-alpha 4792 P25963 NFKBIA human S63 1873119300 PQEVPRGsEPWkQQL X -AURKA AurA O14965 human PKD2 5311 Q13563 PKD2 human S829 4696848 HSSRRRGsISSGVSY X -AURKA AurA O14965 human Cas-L 4739 Q14511 NEDD9 human S296 4696722 PVARRHQsLsPNHPP X -AURKA AurA O14965 human MAP9 79884 Q49MG5 MAP9 human S305 11334001 AVEKSKEsQVTADDL X -AURKA AurA O14965 human WHSC1 7468 O96028 NSD2 human S56 12667955 SkAQLSSsLQEGVMQ X -AURKA AurA O14965 human LATS2 26524 Q9NRM7 LATS2 human S380 3213669 ATLARRDsLQKPGLE X X -AURKA AurA O14965 human DLG7 9787 Q15398 DLGAP5 human S725 456346 CLssERMsLPLLAGG X X -AURKA AurA O14965 human IkB-alpha 4792 P25963 NFKBIA human S262 1873119302 QLTWGRPsTRIQQQL X -AURKA AurA O14965 human LIMK2 3985 P53671 LIMK2 human T505 448683 NDRKKRYtVVGNPYW PK_Tyr_Ser-Thr X X 3841 -AURKA AurA O14965 human AML2 864 Q13761 RUNX3 human T173 55571501 YHRAIkVtVDGPREP Runt X -AURKA AurA O14965 human DLG7 9787 Q15398 DLGAP5 human S830 456348 QEHARHIsFGGNLIt X -AURKA AurA O14965 human HEC1 10403 O14777 NDC80 human S55 459763 PtsERkVsLFGkRts Ndc80_HEC X X -AURKA AurA O14965 human TPX2 22974 Q9ULW0 TPX2 human S121 459996 PAQPQRRsLRLsAQk X X -AURKA AurA O14965 human AurA 6790 O14965 AURKA human S98 457666 PLNNTQKskQPLPsA X -AURKA AurA O14965 human HAUS8 93323 Q9BT25 HAUS8 human S19 20583302 PATGPTNsssAKKKD X X -AURKA AurA O14965 human EB3 22924 Q9UPY8 MAPRE3 human S176 4740060 MQTSGRLsNVAPPCI X X -AURKA AurA O14965 human NuMA-1 4926 Q14980 NUMA1 human T2084 31033005 sPNtRSGtRRsPRIA X -AURKA AurA O14965 human p53 7157 P04637 TP53 human S106 27300200 sQkTYQGsYGFrLGF P53 X X -AURKA AurA O14965 human POU6F1 5463 Q14863 POU6F1 human S197 1869383200 kLDITPKsAQKLKPV Pou X X -AURKA AurA O14965 human NuMA-1 4926 Q14980 NUMA1 human T1812 477991 RsARRRttQIINItM X -AURKA AurA O14965 human BIM 10018 O43521 BCL2L11 human S93 8080215 SsLLSRSssGyFsFD X X -AURKA AurA O14965 human BAP37 11331 Q99623 PHB2 human S39 1868188300 VAyGVREsVFTVEGG X -AURKA AurA O14965 human PIN1 5300 Q13526 PIN1 human S16 447772 PGWEkRMsRSSGRVy WW X X -AURKA AurA O14965 human AKIP 54998 Q9NWT8 AURKAIP1 human S70 999611 MLVPRKMsVSPLESW X X -AURKA AurA O14965 human AurA 6790 O14965 AURKA human S342 457608 QETYKRIsRVEFTFP Pkinase X -AURKA AurA O14965 human BIM 10018 O43521 BCL2L11 human S94 4698178 sLLSRSssGyFsFDT X X -AURKA AurA O14965 human AurA 6790 O14965 AURKA human S104 457667 KskQPLPsAPENNPE X -AURKA AurA O14965 human NuMA-1 4926 Q14980 NUMA1 human S1969 3196643 QEtLRRAsMQPIQIA X -AURKA AurA O14965 human TPX2 398174 Q6NUF4 tpx2.L frog S94 1869508032 KRSsRRMsKKHRQKL X -AURKA AurA O14965 human NuMA-1 4926 Q14980 NUMA1 human T1804 3196649 FLDsGrKtRsARRRt X -AURKA AurA O14965 human SOX8 30812 P57073 SOX8 human S327 4715062 SAPSASAsPTETGPP X X -AURKA AurA O14965 human WDR62 284403 O43379 WDR62 human S32 10989988 VPARRGQssPPPAPP X -AURKA AurA O14965 human KIBRA 23286 Q8IX03 WWC1 human S539 20751200 tsLsPRSsLSsPSPP X X -AURKA AurA O14965 human AR 367 P10275 AR human T282 15605002 VPPAVRPtPCAPLAE Androgen_recep X X -AURKA AurA O14965 human DLG7 9787 Q15398 DLGAP5 human S757 456347 EGMELNSsItSQDVL X -AURKA AurA O14965 human MBD3 53615 O95983 MBD3 human S24 11378200 REEVPRRsGLSAGHR MBD X X -AURKA AurA O14965 human TIFA 92610 Q96CG3 TIFA human T9 50409900 tSFEDADtEEtVTCL X X -AURKA AurA O14965 human FANCA 2175 O15360 FANCA human S165 56757905 HSMFSRLsFCQELWK X X -AURKA AurA O14965 human p53 7157 P04637 TP53 human S215 454242 DrNtFrHsVVVPyEP P53 X X -AURKA AurA O14965 human HEC1 10403 O14777 NDC80 human S69 474513 sGHGsRNsQLGIFss Ndc80_HEC X X -AURKA AurA O14965 human TPX2 22974 Q9ULW0 TPX2 human S125 459997 QRRsLRLsAQkDLEQ X X -AURKA AurA O14965 human LIMK1 3984 P53667 LIMK1 human T508 447808 PDRKKRYtVVGNPYW PK_Tyr_Ser-Thr X X 3841 -AURKA AurA O14965 human NuMA-1 4926 Q14980 NUMA1 human S2087 28722901 tRSGtRRsPRIATTT X -AURKA AurA O14965 human AurA 6790 O14965 AURKA human S83 457665 QKQLQATsVPHPVsR X -AURKA AurA O14965 human NUSAP1 51203 Q9BXS6 NUSAP1 human S240 469451 VPPRGRLsVAstPIs NUSAP X -AURKA AurA O14965 human AurA 6790 O14965 AURKA human S391 457671 TANSSKPsNCQNKES X -AURKA AurA O14965 human hnRNP K 3190 P61978 HNRNPK human S379 483629 syAGGrGsyGDLGGP X X -AURKA AurA O14965 human TACC3 21335 Q9JJ11 Tacc3 mouse S347 474537 ESAWRKQsLyVKFDP X -AURKA AurA O14965 human AurA 6790 O14965 AURKA human T288 448784 APSsRRttLCGtLDy Pkinase X X 3079; 2914; 13464; 8525 -AURKA AurA O14965 human LIMK1 3984 P53667 LIMK1 human S307 3191869 DRsPGAGsLGsPAsQ X X -AURKA AurA O14965 human CENPA 1058 P49450 CENPA human S7 448601 _MGPRRRsRKPEAPR Histone X 2187 -AURKA AurA O14965 human RASSF1 iso2 11186 Q9NS23-2 RASSF1 human S203 484000 TsVRRRtsFYLPKDA RA X X -AURKA AurA O14965 human ER-alpha 2099 P03372 ESR1 human S305 448805 IkRSkkNsLALSLtA X X -AURKA AurA O14965 human LIMK2 3985 P53671 LIMK2 human S283 456167 EGtLRRRsLRRsNsI X X -AURKA AurA O14965 human MCM2 4171 P49736 MCM2 human S220 2201403 NVFkERIsDMCkENR MCM_N X -AURKA AurA O14965 human IkB-alpha 4792 P25963 NFKBIA human S32 448203 LLDDRHDsGLDsMkD X 5210; 2859; 9246; 5209 -AURKA AurA O14965 human AR 367 P10275 AR human S293 15605001 PLAECKGsLLDDsAG Androgen_recep X X -AURKA AurA O14965 human KIF2C 380006 Q91636 kif2c frog S196 2132102 NNQGRRKsNIVKEME X -AURKA AurA O14965 human PKM 5315 P14618 PKM human T45 476071 PPItARNtGIICtIG PK X X -AURKA AurA O14965 human ALDH1A1 216 P00352 ALDH1A1 human T267 14567868 KSNLKRVtLELGGKS Aldedh X X -AURKA AurA O14965 human p53 7157 P04637 TP53 human S315 447530 LPNNtsssPQPkkkP X X 2528 -AURKA AurA O14965 human Geminin 51053 O75496 GMNN human T25 40323301 NSSVPRRtLkMIQPS Geminin X X -AURKA AurA O14965 human KCTD12 115207 Q96CX2 KCTD12 human S200 468044 PLLtPsQsLDGsRRs X -AURKA AurA O14965 human RALA 5898 P11233 RALA human S194 483989 NGKKKRKsLAKRIRE X -AURKA AurA O14965 human RASSF1 iso2 11186 Q9NS23-2 RASSF1 human T202 483999 GTsVRRRtsFYLPKD RA X X -AURKA AurA O14965 human TACC3 10460 Q9Y6A5 TACC3 human S558 474537 ESALRKQsLyLkFDP X X 8842; 5645 -AURKA AurA O14965 human NuMA-1 4926 Q14980 NUMA1 human S1991 487347 RQQRkRVsLEPHQGP X -AURKA AurA O14965 human YY1 7528 P25490 YY1 human S365 15416769 EGCGkRFsLDFNLRT zf-C2H2 X X -AURKA AurA O14965 human CDC25B 994 P30305 CDC25B human S353 452008 VQNkRRRsVtPPEEQ M-inducer_phosp X X -Ikbkb IKKB Q9QY78 rat IkB-alpha 25493 Q63746 Nfkbia rat S32 448203 LVDDRHDsGLDsMKD X 5210; 2859; 9246; 5209 -Ikbkb IKKB Q9QY78 rat SNAP23 64630 O70377 Snap23 rat S120 455263 NVVsKQPsRITNGQP SNAP-25 X -Ikbkb IKKB Q9QY78 rat CARD11 416476 Q5F3W0 RCJMB04_5k17 chicken S578 457640 NRNDSIMsTTPEPPG X -Ikbkb IKKB Q9QY78 rat SNAP23 8773 O00161 SNAP23 human S95 455262 NRTkNFEsGkAykTt SNAP-25 X -Ikbkb IKKB Q9QY78 rat IkB-alpha 25493 Q63746 Nfkbia rat S36 448204 RHDsGLDsMKDEDyE X 5210; 9246 -Ikbkb IKKB Q9QY78 rat SNAP23 64630 O70377 Snap23 rat S95 455262 NRTKNFEsGKNYKAt SNAP-25 X -Stk10 LOK O55098 mouse Moesin 17698 P26041 Msn mouse T558 447706 LGRDKYKtLRQIRQG ERM_C X 3141; 3726; 32600 -GTF2F1 GTF2F1 P35269 human GTF2F1 2962 P35269 GTF2F1 human S385 483594 GGssRGNsRPGtPsA TFIIF_alpha X -GTF2F1 GTF2F1 P35269 human RARG 5916 P13631 RARG human S79 455544 EMVPSsPsPPPPPRV X -GTF2F1 GTF2F1 P35269 human RARG 5916 P13631 RARG human S77 455543 SEEMVPSsPsPPPPP X -GTF2F1 GTF2F1 P35269 human GTF2F1 2962 P35269 GTF2F1 human T389 483595 RGNsRPGtPsAEGGs TFIIF_alpha X -LATS1 LATS1 O95835 human INCENP 3619 Q9NQS7 INCENP human S894 450468 RYHKRtssAVWNsPP X -LATS1 LATS1 O95835 human CDK8 264064 Q8R3L8 Cdk8 mouse S62 1876860402 EGTGISMsACREIAL Pkinase X X -LATS1 LATS1 O95835 human YAP1 10413 P46937 YAP1 human S397 3190672 tyHSRDEstDsGLsM X X -LATS1 LATS1 O95835 human YAP1 10413 P46937 YAP1 human S61 484116 IVHVRGDsEtDLEAL X 75784; 86312 -LATS1 LATS1 O95835 human YAP1 22601 P46938 Yap1 mouse S112 448847 PQHVRAHssPAsLQL X X 4911; 13008; 92367; 57706 -LATS1 LATS1 O95835 human MLK3 4296 Q16584 MAP3K11 human T477 36324901 HVRRRRGtFKRSKLR X X -LATS1 LATS1 O95835 human SASH1 23328 O94885 SASH1 human S407 468680 LSHGRtCsFGGFDLT SLY X -LATS1 LATS1 O95835 human CDC26 246184 Q8NHZ8 CDC26 human T7 10815632 _MLRRKPtRLELKLD ANAPC_CDC26 X X -LATS1 LATS1 O95835 human YAP1 22601 P46938 Yap1 mouse S382 3190672 TyHSRDEstDsGLSM X 13619 -LATS1 LATS1 O95835 human Raptor 57521 Q8N122 RPTOR human S606 53407301 SAHEkLYsLLSDPIP HEAT X X -LATS1 LATS1 O95835 human Snail2 6591 O43623 SNAI2 human T208 25311911 QGHIRtHtGEkPFSC X X -LATS1 LATS1 O95835 human LATS1 9113 O95835 LATS1 human S674 481736 EMMRVGLsQDAQDQM X -LATS1 LATS1 O95835 human LATS1 9113 O95835 LATS1 human S909 457594 HQRCLAHsLVGTPNY Pkinase X 9157 -LATS1 LATS1 O95835 human YAP1 10413 P46937 YAP1 human S381 3190669 LRTMTTNssDPFLNs X -LATS1 LATS1 O95835 human YAP1 iso2 10413 P46937-2 YAP1 human S61 484116 IVHVRGDsEtDLEAL X -LATS1 LATS1 O95835 human MTF1 4520 Q14872 MTF1 human S152 50784002 EGCPRTysTAGNLRT zf-C2H2 X X -LATS1 LATS1 O95835 human PRPS1 5631 P60891 PRPS1 human S285 1874748500 EDkMKHCsKIQVIDI Pribosyl_synth X X -LATS1 LATS1 O95835 human MTF1 17764 Q07243 Mtf1 mouse S151 50784002 EGCPRtYsTAGNLRT zf-C2H2 X -LATS1 LATS1 O95835 human RAF1 5894 P04049 RAF1 human S259 447741 sQRQRststPNVHMV X 9421; 20011 -LATS1 LATS1 O95835 human KIF23 9493 Q02241 KIF23 human S814 470674 LRHRRsRsAGDRWVD MKLP1_Arf_bdg X X -LATS1 LATS1 O95835 human AMOT 154796 Q4VCS5 AMOT human S175 28699604 QGHVRSLsERLMQMS X -LATS1 LATS1 O95835 human YAP1 iso2 10413 P46937-2 YAP1 human S109 452305 KsHsRQAstDAGtAG X 46931; 53749 -LATS1 LATS1 O95835 human KIF23 9493 Q02241 KIF23 human S716 453934 QLHRRsNsCsSISVA X X -LATS1 LATS1 O95835 human YAP1 10413 P46937 YAP1 human S127 448847 PQHVRAHssPAsLQL X X 4911; 13008; 92367; 57706 -LATS1 LATS1 O95835 human LATS1 9113 O95835 LATS1 human S1049 1791602 VDPDkLWsDDNEEEN X -LATS1 LATS1 O95835 human PRPS2 5634 P11908 PRPS2 human T285 1874748502 EDkMkHCtKIQVIDI Pribosyl_synth X X -LATS1 LATS1 O95835 human YAP1 iso2 10413 P46937-2 YAP1 human S127 448847 PQHVRAHssPASLQL X X 57706 -LATS1 LATS1 O95835 human YAP1 10413 P46937 YAP1 human S109 452305 ksHsRQAstDAGtAG X 46931; 53749 -LATS1 LATS1 O95835 human YAP1 iso2 10413 P46937-2 YAP1 human S164 471933 AQHLRQssFEIPDDV X -LATS1 LATS1 O95835 human YAP1 iso2 10413 P46937-2 YAP1 human S381 3190672 TYHSRDEsTDsGLsM X 13619 -LATS1 LATS1 O95835 human TAZ 25937 Q9GZV5 WWTR1 human S89 457660 AQHVRsHssPAsLQL X 75275; 59971 -Stk17b DRAK2 Q8BG48 mouse DRAK2 98267 Q8BG48 Stk17b mouse S12 1851300 RFDCRsVsGLLTTTP X -Stk17b DRAK2 Q8BG48 mouse DRAK2 98267 Q8BG48 Stk17b mouse S351 1735800 PEDGsLVsKRFRFDD X -Stk17b DRAK2 Q8BG48 mouse DRAK2 98267 Q8BG48 Stk17b mouse S362 2627602 RFDDSLPsPHELVPD X -Stk17b DRAK2 Q8BG48 mouse DRAK2 98267 Q8BG48 Stk17b mouse S328 2627603 SEEKTSKsSCNGsCG X -Stk17b DRAK2 Q8BG48 mouse DRAK2 98267 Q8BG48 Stk17b mouse S348 1851301 ENIPEDGsLVsKRFR X -Stk17b DRAK2 Q8BG48 mouse DRAK2 98267 Q8BG48 Stk17b mouse S333 2627601 SKsSCNGsCGAREDK X -Stk17b DRAK2 Q8BG48 mouse DRAK2 98267 Q8BG48 Stk17b mouse S10 2627600 RRRFDCRsVsGLLTT X -Itk ITK Q03526 mouse TBX21 57765 Q9JKD8 Tbx21 mouse Y525 458297 KETEGQFyNYFPN__ X -Itk ITK Q03526 mouse ITK 16428 Q03526 Itk mouse Y186 449834 ETLVIALyDYQTNDP SH3_1 X -PDGFRB PDGFRB P09619 human PDGFRB 5159 P09619 PDGFRB human Y1021 447523 PNEGDNDyIIPLPDP X X 2227 -PDGFRB PDGFRB P09619 human PDGFRA 5156 P16234 PDGFRA human Y754 448439 ERKEVsKysDIQRsL PK_Tyr_Ser-Thr X 2992 -PDGFRB PDGFRB P09619 human PDGFRB 5159 P09619 PDGFRB human Y1009 447522 LDTSSVLyTAVQPNE X X 3124 -PDGFRB PDGFRB P09619 human FAK 5747 Q05397 PTK2 human Y5 7445815 ___MAAAyLDPNLNH X X -PDGFRB PDGFRB P09619 human Arg 27 P42684 ABL2 human Y272 456540 KCNKPTVyGVsPIHD X -PDGFRB PDGFRB P09619 human PDGFRB 5159 P09619 PDGFRB human Y579 447521 VSSDGHEyIyVDPMQ X -PDGFRB PDGFRB P09619 human PDGFRB 5159 P09619 PDGFRB human Y562 458338 LWQKKPRyEIRWKVI X -PDGFRB PDGFRB P09619 human FMIP 8563 Q13769 THOC5 human Y225 25802102 EIEVKKEyLSSLQPR FmiP_Thoc5 X -PDGFRB PDGFRB P09619 human Arg 27 P42684 ABL2 human Y139 7437800 EKLRVLGyNQNGEWS SH3_1 X -PDGFRB PDGFRB P09619 human PLCG1 5335 P19174 PLCG1 human Y783 447667 EGRNPGFyVEANPMP X 2821; 14461; 14008; 25678; 88717 -PDGFRB PDGFRB P09619 human PDGFRB 5159 P09619 PDGFRB human Y740 447520 TGESDGGyMDMSKDE PK_Tyr_Ser-Thr X 3168 -PDGFRB PDGFRB P09619 human Arg 27 P42684 ABL2 human Y439 447923 RLMtGDtytAHAGAk PK_Tyr_Ser-Thr X -PDGFRB PDGFRB P09619 human Fyn 2534 P06241 FYN human Y28 447879 sLNQssGyRyGTDPT X -PDGFRB PDGFRB P09619 human Tel 2120 P41212 ETV6 human Y17 454812 IkQERIsytPPEsPV X X -PDGFRB PDGFRB P09619 human FAK 5747 Q05397 PTK2 human Y194 18122800 ALEKKSNyEVLEkDV FERM_M X X -PDGFRB PDGFRB P09619 human PDGFRB 5159 P09619 PDGFRB human Y763 448850 DMKGDVKyADIESSN PK_Tyr_Ser-Thr X -PDGFRB PDGFRB P09619 human Ack 10188 Q07912 TNK2 human Y635 4251154 PLPPPPAyDDVAQDE X X -PDGFRB PDGFRB P09619 human PDGFRB 5159 P09619 PDGFRB human Y581 447519 SDGHEyIyVDPMQLP X -PDGFRB PDGFRB P09619 human Arg 27 P42684 ABL2 human Y116 2226537 PNLFVALyDFVAsGD SH3_1 X -PDGFRB PDGFRB P09619 human Arg 27 P42684 ABL2 human Y303 456543 GGQyGEVyVGVWKKy PK_Tyr_Ser-Thr X -PDGFRB PDGFRB P09619 human MUC1 4582 P15941 MUC1 human Y1218 473759 tyHtHGRyVPPsstD X -PDGFRB PDGFRB P09619 human Arg 27 P42684 ABL2 human Y310 456544 yVGVWKKysLtVAVK PK_Tyr_Ser-Thr X -PDGFRB PDGFRB P09619 human PDGFRB 5159 P09619 PDGFRB human Y857 447509 DIMRDSNyISKGSTF PK_Tyr_Ser-Thr X X 3170 -PDGFRB PDGFRB P09619 human PDGFRB 5159 P09619 PDGFRB human Y775 449964 SSNyMAPyDNyVPSA PK_Tyr_Ser-Thr X -PDGFRB PDGFRB P09619 human MUC1 4582 P15941 MUC1 human Y1203 454878 IFPARDtyHPMsEyP X -PDGFRB PDGFRB P09619 human PDGFRB 5159 P09619 PDGFRB human Y771 447517 ADIESSNyMAPyDNy PK_Tyr_Ser-Thr X X 3173 -PDGFRB PDGFRB P09619 human Arg 27 P42684 ABL2 human Y161 449482 QGWVPsNyItPVNSL X -PDGFRB PDGFRB P09619 human Tel 2120 P41212 ETV6 human Y27 454813 PEsPVPsyAsstPLH X X -PDGFRB PDGFRB P09619 human Src 6714 P12931 SRC human Y419 448234 RLIEDNEytARQGAk PK_Tyr_Ser-Thr X 2101; 6943; 59548; 70926; 78740; 94361; 17320 -PDGFRB PDGFRB P09619 human PDGFRB 5159 P09619 PDGFRB human Y751 447508 SKDESVDyVPMLDMK PK_Tyr_Ser-Thr X X 3166; 3161; 4549 -PDGFRB PDGFRB P09619 human Arg 27 P42684 ABL2 human Y299 3973063 HKLGGGQyGEVyVGV PK_Tyr_Ser-Thr X -PDGFRB PDGFRB P09619 human PDGFRB 5159 P09619 PDGFRB human Y778 450207 yMAPyDNyVPSAPER PK_Tyr_Ser-Thr X -Vrk1 VRK1 Q80X41 mouse coilin 8161 P38432 COIL human S184 11329300 NEEAKRKsPKKKEKC Coilin_N X -PHKB PHKB P12798 rabbit PHKB 100009137 P12798 PHKB rabbit S12 470137 TGLMAEVsWKVLERR X -PHKB PHKB P12798 rabbit PHKB 100009137 P12798 PHKB rabbit S700 472411 HSKVKRQsSTSNAPE Glyco_hydro_15 X -PHKB PHKB P12798 rabbit PHKB 100009137 P12798 PHKB rabbit S27 470138 ARTKRSGsVYEPLKS X -CDK7 CDK7 P50613 human CDK11B 984 P21127 CDK11B human T595 449142 GsPLKAytPVVVtLW Pkinase X -CDK7 CDK7 P50613 human Rb 5925 P06400 RB1 human S780 447978 strPPtLsPIPHIPr Rb_C X 9307; 3590; 8180 -CDK7 CDK7 P50613 human MCM2 4171 P49736 MCM2 human S5 2201405 ___MAEssEsFtMAs X -CDK7 CDK7 P50613 human Oct4 5460 Q01860 POU5F1 human S12 18496900 LASDFAFsPPPGGGG X -CDK7 CDK7 P50613 human CDK2 1017 P24941 CDK2 human Y168 4319901 HEVVtLWyRAPEILL Pkinase X -CDK7 CDK7 P50613 human ER-alpha 2099 P03372 ESR1 human S118 448101 LHPPPQLsPFLQPHG Oest_recep X X 2511 -CDK7 CDK7 P50613 human CDK6 1021 Q00534 CDK6 human T177 2454600 YSFQMALtSVVVTLW Pkinase X -CDK7 CDK7 P50613 human OGFOD1 55239 Q8N543 OGFOD1 human S256 1874115106 FEPPIPRsPHIPQDH X X -CDK7 CDK7 P50613 human ICK 56542 Q9JKV2 Cilk1 mouse T157 456051 IRSRPPytDyVStRW Pkinase X X -CDK7 CDK7 P50613 human p53 7157 P04637 TP53 human S371 447533 AHssHLkskkGQsts X -CDK7 CDK7 P50613 human SPT5 6829 O00267 SUPT5H human T784 458816 MyGsGsrtPMyGsQt X -CDK7 CDK7 P50613 human MCM2 4171 P49736 MCM2 human S41 452312 RtDALtssPGRDLPP X X -CDK7 CDK7 P50613 human CDK9 1025 P50750 CDK9 human S175 456536 FGLARAFsLAkNSQP Pkinase X X -CDK7 CDK7 P50613 human POLR2A 5430 P24928 POLR2A human S1616 450204 TPQSPSysPtsPsYS RNA_pol_Rpb1_R X X 4735; 13499; 13546; 31262 -CDK7 CDK7 P50613 human MED1 5469 Q15648 MED1 human T1457 449866 HsKsPAytPQNLDsE X X -CDK7 CDK7 P50613 human Oct4 18999 P20263 Pou5f1 mouse S12 18496900 LASDFAFsPPPGGGD X -CDK7 CDK7 P50613 human MCM2 4171 P49736 MCM2 human S13 473057 EsFtMAssPAQRRRG X -CDK7 CDK7 P50613 human RARA 5914 P10276 RARA human S77 455459 EIVPsPPsPPPLPRI X X -CDK7 CDK7 P50613 human XRN2 22803 Q9H0D6 XRN2 human T439 3211959 FtPsGILtPHALGsR XRN_M X -CDK7 CDK7 P50613 human p53 7157 P04637 TP53 human S376 447570 LkskkGQstsRHkkL X -CDK7 CDK7 P50613 human E2F1 1869 Q01094 E2F1 human T433 447871 DCDFGDLtPLDF___ X X -CDK7 CDK7 P50613 human RARA 19401 P11416 Rara mouse S77 455459 EIVPSPPsPPPLPRI X X -CDK7 CDK7 P50613 human SPT5 6829 O00267 SUPT5H human T775 458815 tPMyGsQtPMyGsGs X -CDK7 CDK7 P50613 human SPT5 6829 O00267 SUPT5H human S782 4948434 tPMyGsGsrtPMyGs X -CDK7 CDK7 P50613 human STF-1 26423 P33242 Nr5a1 mouse S203 447603 EYPEPYAsPPQQPGP X -CDK7 CDK7 P50613 human POLR2A 20020 P08775 Polr2a mouse S1619 447616 SPSYsPtsPSYSPTS RNA_pol_Rpb1_R X 4735; 13523; 13546; 67221 -CDK7 CDK7 P50613 human CDK2 1017 P24941 CDK2 human T160 447739 GVPVRtytHEVVtLW Pkinase X 2561 -CDK7 CDK7 P50613 human SPT5 6829 O00267 SUPT5H human S773 15415344 GRtPMyGsQtPMyGs X -CDK7 CDK7 P50613 human POLR2A 5430 P24928 POLR2A human S1621 3439802 SysPtsPsYSPTSPS RNA_pol_Rpb1_R X 13780 -CDK7 CDK7 P50613 human CDK4 1019 P11802 CDK4 human T172 448476 YSYQMALtPVVVTLW Pkinase X -CDK7 CDK7 P50613 human p53 7157 P04637 TP53 human S378 447534 skkGQstsRHkkLMF X -CDK7 CDK7 P50613 human SMAD1 4086 Q15797 SMAD1 human S206 451175 SSStYPHsPTSSDPG X 9553; 5753 -CDK7 CDK7 P50613 human CDK1 983 P06493 CDK1 human T161 447609 GIPIRVytHEVVTLW Pkinase X X 9114 -CDK7 CDK7 P50613 human MCM2 4171 P49736 MCM2 human S4 2201407 ____MAEssEsFtMA X -CDK7 CDK7 P50613 human p53 7157 P04637 TP53 human S392 447535 FktEGPDsD______ X 9281 -CDK7 CDK7 P50613 human MBLR 84108 Q9BYE7 PCGF6 human S30 455506 LPPPPPVsPPALTPA X -CDK7 CDK7 P50613 human FMR1 14265 P35922 Fmr1 mouse S499 469583 NSEAsNAsETESDHR FXMRP1_C_core X -CDK7 CDK7 P50613 human p53 7157 P04637 TP53 human S33 447531 LPENNVLsPLPsQAM X 2526 -CDK7 CDK7 P50613 human POLR2A 5430 P24928 POLR2A human S1619 447616 SPSysPtsPsYSPTS RNA_pol_Rpb1_R X X 4735; 13523; 13546; 67221 -CDK7 CDK7 P50613 human MCM2 4171 P49736 MCM2 human S108 456310 DVEELtAsQREAAER MCM2_N X -CDK7 CDK7 P50613 human XPB 2071 P19447 ERCC3 human S90 1867858202 HIFLEAFsPVYKYAQ Helicase_C_3 X -CDK7 CDK7 P50613 human RARG 5916 P13631 RARG human S79 455544 EMVPSsPsPPPPPRV X -CDK7 CDK7 P50613 human CDK12 51755 Q9NYV4 CDK12 human T893 472551 sEEsRPytNKVITLW Pkinase X -CDK7 CDK7 P50613 human Rb 5925 P06400 RB1 human S807 447980 PGGNIyIsPLksPyk Rb_C X 9308; 8974; 4277; 40283; 8957; 8516; 11917; 99274; 41359; 75864; 72443 -CDK7 CDK7 P50613 human MCM2 4171 P49736 MCM2 human S40 452311 RRtDALtssPGRDLP X -CDK7 CDK7 P50613 human MCM2 4171 P49736 MCM2 human T59 2201408 EsEGLLGtEGPLEEE MCM2_N X -CDK7 CDK7 P50613 human MCM2 4171 P49736 MCM2 human S53 473058 LPPFEDEsEGLLGtE MCM2_N X -CDK7 CDK7 P50613 human MCM2 4171 P49736 MCM2 human S139 454180 RRGLLyDsDEEDEER MCM2_N X X 8861; 12958 -CDK7 CDK7 P50613 human E2F1 1869 Q01094 E2F1 human S403 447870 PEEFISLsPPHEALD X X -CDK7 CDK7 P50613 human Rb 5925 P06400 RB1 human S811 448717 IyIsPLksPykIsEG Rb_C X 9308; 8974; 4277; 40283; 8957; 8516; 11917; 41359; 75864; 63276 -CDK7 CDK7 P50613 human RARG 5916 P13631 RARG human S77 455543 SEEMVPSsPsPPPPP X -CDK7 CDK7 P50613 human GRP78 3309 P11021 HSPA5 human T69 55370298 tPsyVAFtPEGERLI HSP70 X X -CDK7 CDK7 P50613 human MCM2 4171 P49736 MCM2 human S27 452310 GNDPLtssPGRssRR X X -CDK7 CDK7 P50613 human CDK2 1017 P24941 CDK2 human S46 4271962 tETEGVPsTAIREIS Pkinase X -CDK7 CDK7 P50613 human CDK2 1017 P24941 CDK2 human T165 4319900 tytHEVVtLWyRAPE Pkinase X -CDK7 CDK7 P50613 human RARA 19401 P11416 Rara mouse S461 455330 RSsPATQsP______ X -CDK7 CDK7 P50613 human POLR2A 5430 P24928 POLR2A human S1878 3182204 sPKysPtsPtysPtt RNA_pol_Rpb1_R X -CDK7 CDK7 P50613 human MCM2 4171 P49736 MCM2 human S7 2201406 _MAEssEsFtMAssP X -CDK7 CDK7 P50613 human AR 367 P10275 AR human S516 452166 VSRVPYPsPTCVkSE X -CDK7 CDK7 P50613 human STF-1 2516 Q13285 NR5A1 human S203 447603 EYPEPYAsPPQPGLP X X -FGFR4 FGFR4 P22455 human FGFR4 2264 P22455 FGFR4 human Y754 448027 LLAVSEEyLDLRLTF X -FGFR4 FGFR4 P22455 human MST1 6789 Q13043 STK4 human Y433 463558 kIPQDGDyEFLksWt Mst1_SARAH X X -FGFR4 FGFR4 P22455 human GLO1 2739 Q04760 GLO1 human Y136 463450 GIAVPDVysACkRFE Glyoxalase X -Lats1 LATS1 F1M2K4 rat AMOT 154796 Q4VCS5 AMOT human S175 28699604 QGHVRSLsERLMQMS X -Ripk1 RIPK1 Q60855 mouse DRP1 74006 Q8K1M6 Dnm1l mouse S622 454690 PIPIMPAsPQKGHAV X 3455; 4494; 63940 -Ripk1 RIPK1 Q60855 mouse RIPK1 19766 Q60855 Ripk1 mouse S166 27116401 VAsFKTWsKLtKEKD PK_Tyr_Ser-Thr X 31122; 53286 -Mapk8 JNK1 P49185 rat Doublecortin iso2 1641 O43602-2 DCX human T331 469976 SKQsPIStPTsPGSL X -Mapk8 JNK1 P49185 rat STMN1 29332 P13668 Stmn1 rat S38 448556 SVPEFPLsPPKKkDL Stathmin X 3426; 4191 -Mapk8 JNK1 P49185 rat PSD-95 29495 P31016 Dlg4 rat S295 456936 PTsPRRYsPVAKDLL PDZ_assoc X 45737 -Mapk8 JNK1 P49185 rat GR 24413 P06536 Nr3c1 rat S246 451796 LIDENLLsPLAGEDD GCR X X 97285 -Mapk8 JNK1 P49185 rat IRS1 16367 P35569 Irs1 mouse S307 447558 tEsITAtsPAsMVGG X 2381 -Mapk8 JNK1 P49185 rat CTNND2 114028 NP_001258431 Ctnnd2 rat S444 480954 RTSTAPSsPGVDSVP X -Mapk8 JNK1 P49185 rat STMN1 29332 P13668 Stmn1 rat S25 448555 QAFELILsPRSKESV Stathmin X -Mapk8 JNK1 P49185 rat Jun 24516 P17325 Jun rat S73 447943 VGLLKLAsPELERLI Jun X 9164; 3270; 8752; 12714; 77955 -Mapk8 JNK1 P49185 rat MAP2 25595 P15146 Map2 rat T1622 450181 YSSRtPGtPGtPSyP X 4544 -Mapk8 JNK1 P49185 rat MAP2 25595 P15146 Map2 rat T1619 4704347 PPsYSSRtPGtPGtP X -Mapk8 JNK1 P49185 rat Doublecortin iso2 1641 O43602-2 DCX human T321 451361 TSSSQLStPKSKQsP X -Mapk8 JNK1 P49185 rat IRS1 25467 P35570 Irs1 rat S307 447558 TEsITATsPASMVGG X 2381 -Mapk8 JNK1 P49185 rat Doublecortin iso2 1641 O43602-2 DCX human S334 451359 sPIStPTsPGSLRkH X 3453; 14053 -Mapk8 JNK1 P49185 rat MAP2 25595 P15146 Map2 rat T1625 450182 RtPGtPGtPSyPRTP X 4544 -Mapk8 JNK1 P49185 rat IRS2 29376 F1MAL5 Irs2 rat T348 483924 RTDsLAAtPPAAKCT X -DYRK4 DYRK4 Q9NR20 human DYRK4 8798 Q9NR20 DYRK4 human Y264 454665 EHQKVytyIQsRFYR Pkinase X -Ptk2 FAK iso2 P34152-2 mouse FAK 14083 P34152 Ptk2 mouse Y397 447887 sVsEtDDyAEIIDEE X X 3283; 8556 -Ptk2 FAK iso2 P34152-2 mouse SHC1 iso2 6464 P29353-2 SHC1 human Y317 448511 ELFDDPSyVNVQNLD X -Ptk2 FAK iso2 P34152-2 mouse Cortactin 13043 Q60598 Cttn mouse Y421 447702 RPPssPIyEDAAPFK X 4569 -Ptk2 FAK iso2 P34152-2 mouse N-WASP 73178 Q91YD9 Wasl mouse Y253 450253 RETSKVIyDFIEKTG PBD X X -Ptk2 FAK iso2 P34152-2 mouse FAK iso2 14083 P34152-2 Ptk2 mouse Y428 447887 SGDETDDyAEIIDEE X 3283; 8556 -Ptk2 FAK iso2 P34152-2 mouse Cortactin 13043 Q60598 Cttn mouse Y466 447703 TyTSEPVyETTEAPG X -Ptk2 FAK iso2 P34152-2 mouse ARHGEF7 8874 Q14155 ARHGEF7 human Y620 3753309 PAPLtPAyHTLPHPS X -Ptk2 FAK iso2 P34152-2 mouse P130Cas 12927 Q61140 Bcar1 mouse Y668 448399 EGGWMEDyDyVHLQG CAS_C X -Ptk2 FAK iso2 P34152-2 mouse Cortactin 13043 Q60598 Cttn mouse Y482 447704 yQAEDDTyDGYESDL X -Egfr EGFR Q01279 mouse EGFR 13649 Q01279 Egfr mouse Y1197 448060 PTAENAEyLRVAPPS X 2244; 4407; 47737 -Egfr EGFR Q01279 mouse EPS15 13858 P42567 Eps15 mouse Y850 450484 NFANFSAyPsEEDMI X -Egfr EGFR Q01279 mouse GAB1 14388 Q9QYY0 Gab1 mouse Y448 449791 GEELDENyVPMNPNs X -Egfr EGFR Q01279 mouse PIP5K1C 18717 O70161 Pip5k1c mouse Y634 486321 DAPSTDIyFPTDERS X -Egfr EGFR Q01279 mouse GAB1 14388 Q9QYY0 Gab1 mouse Y407 447946 DASsQDCyDIPRtFP X -Egfr EGFR Q01279 mouse GAB1 14388 Q9QYY0 Gab1 mouse Y590 449792 SHDSEENyVPMNPNL X -Egfr EGFR Q01279 mouse hnRNP P2 233908 P56959 Fus mouse Y6 1869633701 __MASNDyTQQATQS X -Egfr EGFR Q01279 mouse GAB1 14388 Q9QYY0 Gab1 mouse Y628 447948 KGDKQVEyLDLDLDs X 3231; 3233 -Egfr EGFR Q01279 mouse GAB1 14388 Q9QYY0 Gab1 mouse Y473 447947 EPIQEPNyVPMtPGT X -Egfr EGFR Q01279 mouse GAB1 14388 Q9QYY0 Gab1 mouse Y660 447949 MADERVDyVVVDQQK X 12745 -Egfr EGFR Q01279 mouse PKACA 18747 P05132 Prkaca mouse Y331 15230353 DTSNFDDyEEEEIRV X -Egfr EGFR Q01279 mouse PLD2 18806 P97813 Pld2 mouse Y11 450938 TQKNLFPyGDyLNSS X -Egfr EGFR Q01279 mouse GAB1 14388 Q9QYY0 Gab1 mouse Y373 447945 ASDtDSSyCIPPPAG X -Egfr EGFR Q01279 mouse GAB1 14388 Q9QYY0 Gab1 mouse Y285 449801 TEADGELyTFNTPSG X -Egfr EGFR Q01279 mouse ZNRF1 170737 Q91V17 Znrf1 mouse Y103 479016 TyAHGNGyQETGGGH X -Egfr EGFR Q01279 mouse CBL 867 P22681 CBL human Y371 449753 TQEQyELyCEMGSTF X -Egfr EGFR Q01279 mouse hnRNP P2 233908 P56959 Fus mouse Y297 1869633700 TIESVADyFKQIGII RRM_1 X -Egfr EGFR Q01279 mouse GAB1 14388 Q9QYY0 Gab1 mouse Y307 447944 MRHVsISyDIPPtPG X 3234 -Egfr EGFR Q01279 mouse EGFR 13649 Q01279 Egfr mouse Y1069 448056 EDAFLQRyssDPtGA X -STK38 NDR1 Q15208 human YAP1 10413 P46937 YAP1 human S61 484116 IVHVRGDsEtDLEAL X 75784; 86312 -STK38 NDR1 Q15208 human YAP1 10413 P46937 YAP1 human S164 471933 AQHLRQssFEIPDDV X -STK38 NDR1 Q15208 human Exportin-1 7514 O14980 XPO1 human S1055 453528 EKHKRQMsVPGIFNP X -STK38 NDR1 Q15208 human NDR1 11329 Q15208 STK38 human T444 460659 DWVFINytyKRFEGL Pkinase_C X X -STK38 NDR1 Q15208 human RAB3IP 117177 Q96QF0 RAB3IP human S288 4734219 KGHTRNKstSSAMSG X -STK38 NDR1 Q15208 human KIF23 9493 Q02241 KIF23 human S814 470674 LRHRRsRsAGDRWVD MKLP1_Arf_bdg X -STK38 NDR1 Q15208 human KIF23 9493 Q02241 KIF23 human S716 453934 QLHRRsNsCsSISVA X -STK38 NDR1 Q15208 human YAP1 10413 P46937 YAP1 human S127 448847 PQHVRAHssPAsLQL X X 4911; 13008; 92367; 57706 -STK38 NDR1 Q15208 human NDR1 11329 Q15208 STK38 human S281 448828 NRRQLAFstVGtPDy Pkinase X X -STK38 NDR1 Q15208 human YAP1 10413 P46937 YAP1 human S109 452305 ksHsRQAstDAGtAG X 46931; 53749 -PRKAG2 AMPKG2 Q9UGJ0 human 53BP1 7158 Q12888 TP53BP1 human S1317 476252 SSLHRtssGtsLSAM X -PRKAG2 AMPKG2 Q9UGJ0 human SF2 6426 Q07955 SRSF1 human S133 15178110 SGLPPSGsWQDLkDH RRM_1 X -PRKAG2 AMPKG2 Q9UGJ0 human TIF1A 54700 Q9NYV6 RRN3 human S635 11315000 DTHFRsPssSVGsPP X -PRKAG2 AMPKG2 Q9UGJ0 human PDHA1 5160 P08559 PDHA1 human S314 1868287349 IQEVRSksDPIMLLk E1_dh X -PRKAG2 AMPKG2 Q9UGJ0 human STIM1 6786 Q13586 STIM1 human S521 468874 RDLtHsDsEssLHMs X -PRKAG2 AMPKG2 Q9UGJ0 human PDHA1 5160 P08559 PDHA1 human S295 468391 RyHGHsMsDPGVsyR E1_dh X -PRKAG2 AMPKG2 Q9UGJ0 human STIM1 6786 Q13586 STIM1 human S257 468872 GLHRAEQsLHDLQER X -PRKAG2 AMPKG2 Q9UGJ0 human SKP2 27401 Q9Z0Z3 Skp2 mouse S256 1296362400 ATLLSSCsRLDELNL X -PRKAG2 AMPKG2 Q9UGJ0 human SKP2 6502 Q13309 SKP2 human S256 1296362400 QTLLSSCsRLDELNL X -PRKAG2 AMPKG2 Q9UGJ0 human NEDD4L 23327 Q96PU5 NEDD4L human S795 18963100 VDLKPNGsEIMVTNE HECT X -Fyn Fyn P39688 mouse FCGR2C 9103 P31995 FCGR2C human Y310 449501 tDDDKNIyLTLPPND X -Fyn Fyn P39688 mouse CD3E 12501 P22646 Cd3e mouse Y170 448918 PPVPNPDyEPIRKGQ ITAM X -Fyn Fyn P39688 mouse NOX4 50490 Q9JHI8 Nox4 mouse Y566 57848101 LSNRNNSyGTkFEYN X -Fyn Fyn P39688 mouse NYAP2 241134 Q8BM65 Nyap2 mouse Y300 455105 DDQSEAVyEEMKYPI NYAP_N X -Fyn Fyn P39688 mouse NRF2 18024 Q60795 Nfe2l2 mouse Y568 460703 RDEDGKPySPSEYSL X -Fyn Fyn P39688 mouse FCGR2A 2212 P12318 FCGR2A human Y304 449552 tDDDKNIyLTLPPND X -Fyn Fyn P39688 mouse GPRC5B 64297 Q923Z0 Gprc5b mouse Y307 6158489 LQENPPNyFDTSQPR X X -Fyn Fyn P39688 mouse RIAM 54519 Q8R5A3 Apbb1ip mouse Y267 1871479100 FLEKEERyAVFKNPQ X -Fyn Fyn P39688 mouse PKCD 18753 P28867 Prkcd mouse Y311 447573 TTEsVGIyQGFEKKP X X 2055 -Fyn Fyn P39688 mouse NMDAR2B 14812 Q01097 Grin2b mouse Y1472 448167 GSSNGHVyEKLSSIE NMDAR2_C X 4208 -Fyn Fyn P39688 mouse NMDAR2B 14812 Q01097 Grin2b mouse Y1252 448165 CKKAGNLyDIsEDNs NMDAR2_C X -Fyn Fyn P39688 mouse KIRREL 170643 Q80W68 Kirrel1 mouse Y716 455015 DTTSQLSyENyEKFN X -Fyn Fyn P39688 mouse GABRG2 14406 P22723 Gabrg2 mouse Y413 455818 ERDEEyGyECLDGKD Neur_chan_memb X -Fyn Fyn P39688 mouse NMDAR2B 14812 Q01097 Grin2b mouse Y1336 448166 RFMDGsPyAHMFEMP NMDAR2_C X -Fyn Fyn P39688 mouse KIRREL 170643 Q80W68 Kirrel1 mouse Y638 463752 kDPTNGyyNVRAHED X -Fyn Fyn P39688 mouse Srcasm 71943 Q923U0 Tom1l1 mouse Y441 451209 DLQPPNyyEVMEFDP X -Fyn Fyn P39688 mouse CTNNB1 12387 Q02248 Ctnnb1 mouse Y142 449044 AVVNLINyQDDAELA X -Fyn Fyn P39688 mouse IRS1 25467 P35570 Irs1 rat Y895 447556 EPKsPGEyVNIEFGS X 3070 -Fyn Fyn P39688 mouse INDO 15930 P28776 Ido1 mouse Y253 21393601 KLPEGLLyEGVWDTP IDO X -Fyn Fyn P39688 mouse Israa 100188919 B2CXA1 Israa mouse Y102 54065300 PSQLVPEyTEVTSLQ X -Fyn Fyn P39688 mouse CD3E 12501 P22646 Cd3e mouse Y181 448917 RKGQRDLySGLNQRA ITAM X -Fyn Fyn P39688 mouse GPRC5B 64297 Q923Z0 Gprc5b mouse Y330 3972629 EMHLPRAyMENkAFs X X -Fyn Fyn P39688 mouse RIAM 54519 Q8R5A3 Apbb1ip mouse Y427 1871479101 AKYGKTLyDNYQRAV X -Fyn Fyn P39688 mouse IRS1 25467 P35570 Irs1 rat Y1172 451288 GLEKSLNyIDLDLVK X -Fyn Fyn P39688 mouse Srcasm 71943 Q923U0 Tom1l1 mouse Y440 2263200 GDLQPPNyyEVMEFD X -Fyn Fyn P39688 mouse PKCD 18753 P28867 Prkcd mouse Y332 450077 ILDNNGTyGKIWEGS X -Fyn Fyn P39688 mouse WASP 22376 P70315 Was mouse Y293 447985 AETsKLIyDFIEDQG PBD X X -Fyn Fyn P39688 mouse Srcasm 71943 Q923U0 Tom1l1 mouse Y457 451210 APTTEAVyEEIDGYH X -Fyn Fyn P39688 mouse Srcasm 71943 Q923U0 Tom1l1 mouse Y392 451208 NLASSHTyDNFHSNS X -Fyn Fyn P39688 mouse TIM-1 171283 Q5QNS5 Havcr1 mouse Y299 20842101 SRAEDNIyIVEDRP_ X -Fyn Fyn P39688 mouse PSD-93 23859 Q91XM9 Dlg2 mouse Y348 450885 tRPPEPVystVNKLC X -Fyn Fyn P39688 mouse CDK5 12568 P49615 Cdk5 mouse Y15 448022 EkIGEGtyGtVFKAK Pkinase X 94254; 19051 -Fyn Fyn P39688 mouse KIRREL 170643 Q80W68 Kirrel1 mouse Y719 455014 SQLSyENyEKFNSHP X -Fyn Fyn P39688 mouse CTLA-4 12477 P09793 Ctla4 mouse Y201 450897 SPLTTGVyVKMPPTE X -Fyn Fyn P39688 mouse cytohesin 2 19158 P63034 Cyth2 mouse Y381 4003314 AVSVDPFyEMLAARK X -Fyn Fyn P39688 mouse GPRC5B 64297 Q923Z0 Gprc5b mouse Y383 462507 APFRsNVyQPtEMAV X X -Fyn Fyn P39688 mouse NYAP2 241134 Q8BM65 Nyap2 mouse Y277 455101 PEEEEPVyIEMVGNI NYAP_N X -Fyn Fyn P39688 mouse KIRREL 170643 Q80W68 Kirrel1 mouse Y637 463751 MkDPTNGyyNVRAHE X -Fyn Fyn P39688 mouse CTLA-4 12477 P09793 Ctla4 mouse Y218 450898 CEKQFQPyFIPIN__ X -PRKAA1 AMPKA1 Q13131 human AMPKB1 5564 Q9Y478 PRKAB1 human S108 448522 skLPLTRsHNNFVAI AMPK1_CBM X 23021 -PRKAA1 AMPKA1 Q13131 human DRP1 74006 Q8K1M6 Dnm1l mouse S643 483971 VPVARKLsAREQRDC X 4867; 6319 -PRKAA1 AMPKA1 Q13131 human Tau iso8 4137 P10636-8 MAPT human T231 449079 KKVAVVRtPPKsPss X 20473; 71429 -PRKAA1 AMPKA1 Q13131 human ALDH2 217 P05091 ALDH2 human T356 1273608200 GNPFDSktEQGPQVD Aldedh X -PRKAA1 AMPKA1 Q13131 human ATG9A 79065 Q7Z3C6 ATG9A human S761 4722321 QsIPRsAsYPCAAPR X X -PRKAA1 AMPKA1 Q13131 human NRF2 18024 Q60795 Nfe2l2 mouse S550 10292703 HLLKRRLsTLYLEVF bZIP_Maf X -PRKAA1 AMPKA1 Q13131 human HSL 25330 P15304 Lipe rat S865 448804 ESMRRsVsEAALAQP X 4137 -PRKAA1 AMPKA1 Q13131 human PDE4B 18578 Q8VBU5 Pde4b mouse S304 4765135 KKLMHsssLNNtSIS X -PRKAA1 AMPKA1 Q13131 human CBCP1 219771 Q8ND76 CCNY human S326 453488 SARKRsAsADNLtLP X X -PRKAA1 AMPKA1 Q13131 human DBI 1622 P07108 DBI human S21 1880114700 RHLkTkPsDEEMLFI X X -PRKAA1 AMPKA1 Q13131 human OGT 26295 P56558 Ogt rat T444 31828209 EAIASYRtALKLKPD TPR_11 X X -PRKAA1 AMPKA1 Q13131 human FOXO3A 56484 Q9WVH4 Foxo3 mouse S412 12084437 GLMQRGSsFPYTAKs X -PRKAA1 AMPKA1 Q13131 human NET1 10276 Q7Z628 NET1 human S100 3204288 RPLARVTsLANLIsP X -PRKAA1 AMPKA1 Q13131 human IRS1 3667 P35568 IRS1 human S794 447557 QHLRLSTsSGRLLyA X 2389 -PRKAA1 AMPKA1 Q13131 human fumarase 2271 P07954 FH human S75 116533304 yGAQTVRsTMNFkIG Lyase_1 X X -PRKAA1 AMPKA1 Q13131 human PD-L1 29126 Q9NZQ7 CD274 human S283 14735979 DTNsKkQsDtHLEEt X X -PRKAA1 AMPKA1 Q13131 human PARK2 5071 O60260 PRKN human S9 11096954 IVFVRFNssHGFPVE ubiquitin X X -PRKAA1 AMPKA1 Q13131 human AMOTL1 154810 Q8IY63 AMOTL1 human S793 7103446 SSLRPARsVPsIAAA Angiomotin_C X X -PRKAA1 AMPKA1 Q13131 human AMPKA1 5562 Q13131 PRKAA1 human S494 4717473 GtAtPQRsGsVsNyR AdenylateSensor X -PRKAA1 AMPKA1 Q13131 human SNX17 9784 Q15036 SNX17 human S437 468793 VkLSskLsAVsLRGI X -PRKAA1 AMPKA1 Q13131 human HDAC5 10014 Q9UQL6 HDAC5 human S498 447996 RPLSRtQsSPLPQsP X X 3424 -PRKAA1 AMPKA1 Q13131 human mTOR 56717 Q9JLN9 Mtor mouse T2446 450853 NKRsRtRtDsysAGQ X X -PRKAA1 AMPKA1 Q13131 human HIPK2 28996 Q9H2X6 HIPK2 human S121 28847902 LMRRStVsLLDTYQK X -PRKAA1 AMPKA1 Q13131 human TBC1D1 57915 Q60949 Tbc1d1 mouse S700 2228807 KKLHssssVPNFLKF X 6929 -PRKAA1 AMPKA1 Q13131 human PTS 5805 Q03393 PTS human T58 1869465810 HNYKVVVtVHGEIDP PTPS X X -PRKAA1 AMPKA1 Q13131 human MCU 90550 Q8NE86 MCU human S57 27259016 TVHQRIAsWQNLGAV X X -PRKAA1 AMPKA1 Q13131 human GAPDH 2597 P04406 GAPDH human S122 31881707 GAkRVIIsAPsADAP X -PRKAA1 AMPKA1 Q13131 human GFAT iso2 2673 Q06210-2 GFPT1 human S243 467935 CNLsRVDsttCLFPV X X -PRKAA1 AMPKA1 Q13131 human STX16 228960 Q8BVI5 Stx16 mouse T7 4754210 _MATRRLtDAFLLLR X -PRKAA1 AMPKA1 Q13131 human DRP1 10059 O00429 DNM1L human S637 483971 VPVARKLsAREQRDC X 4867; 6319 -PRKAA1 AMPKA1 Q13131 human eNOS 4846 P29474 NOS3 human S1177 447884 TSRIRtQsFsLQERQ X 9571; 9570 -PRKAA1 AMPKA1 Q13131 human VASP 7408 P50552 VASP human T278 448381 LARRRKAtQVGEktP X -PRKAA1 AMPKA1 Q13131 human ACC1 31 Q13085 ACACA human S80 448292 LHIRssMsGLHLVkQ X 3661; 11818; 42801 -PRKAA1 AMPKA1 Q13131 human AMPKA1 5562 Q13131 PRKAA1 human T388 7712505 EtPRARHtLDELNPQ X -PRKAA1 AMPKA1 Q13131 human HSF1 15499 P38532 Hsf1 mouse S121 455480 NIKRKVTsVstLKSE X X -PRKAA1 AMPKA1 Q13131 human PPP1R3C 5507 Q9UQK1 PPP1R3C human S293 6423501 LEStIFGsPRLASGL X -PRKAA1 AMPKA1 Q13131 human 53BP1 7158 Q12888 TP53BP1 human S1317 476252 SSLHRtssGtsLSAM X -PRKAA1 AMPKA1 Q13131 human JAK1 3716 P23458 JAK1 human S518 62372201 GSDRsFPsLGDLMsH X -PRKAA1 AMPKA1 Q13131 human YAP1 10413 P46937 YAP1 human S61 484116 IVHVRGDsEtDLEAL X X 75784; 86312 -PRKAA1 AMPKA1 Q13131 human CAMKK2 83506 O88831 Camkk2 rat T144 15425433 PRMPRRPtVESHHVS X X -PRKAA1 AMPKA1 Q13131 human SF2 6426 Q07955 SRSF1 human S133 15178110 SGLPPSGsWQDLkDH RRM_1 X -PRKAA1 AMPKA1 Q13131 human BTRC 8945 Q9Y297 BTRC human S82 1869876000 SLRQTYNsCARLCLN X -PRKAA1 AMPKA1 Q13131 human RACK1 10399 P63244 RACK1 human T50 23136904 WkLtrDEtNyGIPQR X X -PRKAA1 AMPKA1 Q13131 human AMPKB1 5564 Q9Y478 PRKAB1 human S174 7447518 MVDsQKCsDVsELss X -PRKAA1 AMPKA1 Q13131 human TBC1D1 57915 Q60949 Tbc1d1 mouse S231 2103609 RPMRKsFsQPGLRSL X -PRKAA1 AMPKA1 Q13131 human CAMKK2 83506 O88831 Camkk2 rat T446 286046005 IkLHPWVtRHGAEPL X -PRKAA1 AMPKA1 Q13131 human laforin 7957 O95278 EPM2A human S25 20583300 PELLVVGsRPELGRW CBM_20 X X -PRKAA1 AMPKA1 Q13131 human NRF2 4780 Q16236 NFE2L2 human S374 35497700 GDtLLGLsDsEVEEL X X -PRKAA1 AMPKA1 Q13131 human TSC2 iso2 24855 P49816-2 Tsc2 rat S1346 450212 QPLsKSSsSPELQTL X X 5584; 23402 -PRKAA1 AMPKA1 Q13131 human AMPKB1 5564 Q9Y478 PRKAB1 human T158 7712506 NIIQVKktDFEVFDA AMPK1_CBM X -PRKAA1 AMPKA1 Q13131 human AML3 860 Q13950 RUNX2 human S118 460037 AELVRTDsPNFLCSV Runt X X -PRKAA1 AMPKA1 Q13131 human TIF1A 54700 Q9NYV6 RRN3 human S635 11315000 DTHFRsPssSVGsPP X X -PRKAA1 AMPKA1 Q13131 human SQSTM1 18412 Q64337 Sqstm1 mouse S351 14580829 SsKEVDPsTGELQsL X 95697; 16177; 12074 -PRKAA1 AMPKA1 Q13131 human KLC2 64837 Q9H0B6 KLC2 human S545 3892542 GsLRRsGsFGKLRDA X -PRKAA1 AMPKA1 Q13131 human ATP6V1A 11964 P50516 Atp6v1a mouse S384 485978 YLGARLAsFYERAGR ATP-synt_ab X X -PRKAA1 AMPKA1 Q13131 human HIPK2 28996 Q9H2X6 HIPK2 human T119 28847903 HNLMRRStVsLLDTY X -PRKAA1 AMPKA1 Q13131 human PARP1 142 P09874 PARP1 human S177 18013484 LGFRPEYsAsQLkGF zf-PARP X -PRKAA1 AMPKA1 Q13131 human YAP1 10413 P46937 YAP1 human S94 3253276 RLRkLPDsFFkPPEP X X -PRKAA1 AMPKA1 Q13131 human NRF2 4780 Q16236 NFE2L2 human S408 10292700 GDMVQPLsPSQGQST X X -PRKAA1 AMPKA1 Q13131 human KPNA2 3838 P52292 KPNA2 human S105 454033 QAARkLLsREkQPPI X X -PRKAA1 AMPKA1 Q13131 human PDHA1 5160 P08559 PDHA1 human S314 1868287349 IQEVRSksDPIMLLk E1_dh X X -PRKAA1 AMPKA1 Q13131 human TBC1D1 57915 Q60949 Tbc1d1 mouse T499 2228808 NRAKRsLtEsLEsIL X -PRKAA1 AMPKA1 Q13131 human SIRT7 209011 Q8BKJ9 Sirt7 mouse T264 1874512900 EAAsKADtILCLGSS SIR2 X -PRKAA1 AMPKA1 Q13131 human PDE4B 18578 Q8VBU5 Pde4b mouse S125 4765110 sFLYRSDsDyDLsPK X -PRKAA1 AMPKA1 Q13131 human Tau iso8 4137 P10636-8 MAPT human S214 447929 GsRsRtPsLPtPPtR X 77348 -PRKAA1 AMPKA1 Q13131 human EEF2K 29904 O00418 EEF2K human S398 450686 DsLPssPssAtPHSQ X X -PRKAA1 AMPKA1 Q13131 human CAMKK2 83506 O88831 Camkk2 rat S510 2861414 RREERSLsAPGNLLt X 12818 -PRKAA1 AMPKA1 Q13131 human ULK1 22241 O70405 Ulk1 mouse S317 35495300 SHLASPPsLGEMPQL X X 12753; 37762 -PRKAA1 AMPKA1 Q13131 human SMPD3 55512 Q9NY59 SMPD3 human S209 17547980 GsIKRTAsVEyKGDG X -PRKAA1 AMPKA1 Q13131 human PFKFB2 5208 O60825 PFKFB2 human S466 448460 PVRMRRNsFtPLssS X -PRKAA1 AMPKA1 Q13131 human CFTR 1080 P13569 CFTR human S737 449981 EPLERRLsLVPDSEQ CFTR_R X -PRKAA1 AMPKA1 Q13131 human PERK 9451 Q9NZJ5 EIF2AK3 human S715 4270777 HIEIIAPsPQRsRSF X -PRKAA1 AMPKA1 Q13131 human STIM1 6786 Q13586 STIM1 human S521 468874 RDLtHsDsEssLHMs X -PRKAA1 AMPKA1 Q13131 human Tau iso8 4137 P10636-8 MAPT human S356 449104 rVQskIGsLDNItHV Tubulin-binding X -PRKAA1 AMPKA1 Q13131 human ACC1 107476 Q5SWU9 Acaca mouse S79 448292 FHMRSsMsGLHLVKQ X 3661; 11818; 42801 -PRKAA1 AMPKA1 Q13131 human eNOS 4846 P29474 NOS3 human S633 448637 WRRKRKEssNtDsAG Flavodoxin_1 X -PRKAA1 AMPKA1 Q13131 human PARK2 50873 Q9WVS6 Prkn mouse S9 11096954 IVFVRFNsSYGFPVE ubiquitin X X -PRKAA1 AMPKA1 Q13131 human Kv1.5 3741 P22460 KCNA5 human S592 1269647506 KCNVKAKsNVDLRRS X X -PRKAA1 AMPKA1 Q13131 human FOXO3A 2309 O43524 FOXO3 human S626 20799905 SLECDMEsIIRSELM FOXO-TAD X X -PRKAA1 AMPKA1 Q13131 human p27Kip1 1027 P46527 CDKN1B human T198 448781 PGLRRRQt_______ X -PRKAA1 AMPKA1 Q13131 human EXO1 9156 Q9UQ84 EXO1 human S746 1240803 PGLYkSSsADsLStT X -PRKAA1 AMPKA1 Q13131 human GLI1 2735 P08151 GLI1 human S408 41595600 GPLPRAPsISTVEPk X X -PRKAA1 AMPKA1 Q13131 human DDIT3 1649 P35638 DDIT3 human S30 455503 EDLQEVLssDENGGT X X -PRKAA1 AMPKA1 Q13131 human RBBP7 5931 Q16576 RBBP7 human S314 63080403 LkLHTFEsHkDEIFQ WD40 X X -PRKAA1 AMPKA1 Q13131 human DYNC1I2 13427 O88487 Dync1i2 mouse S81 449148 PIVPPPMsPssKsVs X X -PRKAA1 AMPKA1 Q13131 human TET2 214133 Q4JK59 Tet2 mouse S97 3202572 GGIKRtVsEPSLsGL X -PRKAA1 AMPKA1 Q13131 human PRPS2 5634 P11908 PRPS2 human S180 18014264 GGAkRVTsIADrLNV X X -PRKAA1 AMPKA1 Q13131 human PPP1R12C 54776 Q9BZL4 PPP1R12C human S452 472608 AGLQRsAsssWLEGt X -PRKAA1 AMPKA1 Q13131 human genethonin 1 8987 O95210 STBD1 human S175 469665 CFAEKLPssNLLKNR X -PRKAA1 AMPKA1 Q13131 human ARHGEF7 114559 O55043 Arhgef7 rat S71 3573357 KPSEkPVsPKSGTLK X X -PRKAA1 AMPKA1 Q13131 human PAQR3 152559 Q6TCH7 PAQR3 human T32 53998800 PRGIRLYtyEQIPGS X X -PRKAA1 AMPKA1 Q13131 human KLC2 64837 Q9H0B6 KLC2 human S582 452949 PRMKRAssLNFLNKs X -PRKAA1 AMPKA1 Q13131 human SMPD3 58994 Q9JJY3 Smpd3 mouse S208 17547980 GsIKRTAsVEYKGDG X -PRKAA1 AMPKA1 Q13131 human p53 7157 P04637 TP53 human T18 447541 EPPLsQEtFsDLWkL P53_TAD X 2529 -PRKAA1 AMPKA1 Q13131 human EGFR 1956 P00533 EGFR human T892 41590814 SILHRIytHQSDVWS PK_Tyr_Ser-Thr X -PRKAA1 AMPKA1 Q13131 human AMPKA1 5562 Q13131 PRKAA1 human S486 3195155 DEItEAksGtAtPQR AdenylateSensor X -PRKAA1 AMPKA1 Q13131 human MED1 19014 Q925J9 Med1 mouse S671 1210794 sPLERQNsssGsPRM X -PRKAA1 AMPKA1 Q13131 human GBF1 8729 Q92538 GBF1 human T1338 454448 GKIHRsAtDADVVNs X X -PRKAA1 AMPKA1 Q13131 human Tau iso8 4137 P10636-8 MAPT human S396 449081 GAEIVyKsPVVsGDt X 9632 -PRKAA1 AMPKA1 Q13131 human PDE4B 18578 Q8VBU5 Pde4b mouse S118 449097 GHSQRREsFLYRSDs X -PRKAA1 AMPKA1 Q13131 human TBC1D1 57915 Q60949 Tbc1d1 mouse S621 2228806 RKLMRYHsVstETPH X -PRKAA1 AMPKA1 Q13131 human UMPS 7372 P11172 UMPS human S214 3180453 VAANHNGsPLsIkEA X -PRKAA1 AMPKA1 Q13131 human p53 7157 P04637 TP53 human S20 447529 PLsQEtFsDLWkLLP P53_TAD X 9287 -PRKAA1 AMPKA1 Q13131 human PRPS1 5631 P60891 PRPS1 human S180 18014261 GGAkRVTsIADrLNV X X -PRKAA1 AMPKA1 Q13131 human TNNI3 7137 P19429 TNNI3 human S23 448423 PAPIRRRssNyRAyA Troponin-I_N X 4004 -PRKAA1 AMPKA1 Q13131 human HOXB9 15417 P20615 Hoxb9 mouse T133 31087958 GELLKQGtPEYSLET Hox9_act X X -PRKAA1 AMPKA1 Q13131 human PDHA1 5160 P08559 PDHA1 human S295 468391 RyHGHsMsDPGVsyR E1_dh X X -PRKAA1 AMPKA1 Q13131 human STIM1 6786 Q13586 STIM1 human S257 468872 GLHRAEQsLHDLQER X -PRKAA1 AMPKA1 Q13131 human beclin 1 8678 Q14457 BECN1 human S93 5473540 ARMMstEsANsFTLI X 14717 -PRKAA1 AMPKA1 Q13131 human EGLN1 54583 Q9GZT9 EGLN1 human S61 56668114 HKLVCQGsEGALGHG X X -PRKAA1 AMPKA1 Q13131 human Raptor 57521 Q8N122 RPTOR human S792 2314600 DKMRRAssYSsLNSL X X 2083; 89146 -PRKAA1 AMPKA1 Q13131 human CAMKK2 83506 O88831 Camkk2 rat S110 286046004 RSQGGPAsSSSLDMN X -PRKAA1 AMPKA1 Q13131 human AMPKA1 5562 Q13131 PRKAA1 human S496 450431 AtPQRsGsVsNyRSC AdenylateSensor X 4185; 4184; 2537 -PRKAA1 AMPKA1 Q13131 human PERK 9451 Q9NZJ5 EIF2AK3 human S856 23130887 SEATLsIsPPRPTTL X -PRKAA1 AMPKA1 Q13131 human MED1 19014 Q925J9 Med1 mouse S771 1219246 QRMVRLsssDsIGPD X -PRKAA1 AMPKA1 Q13131 human SIRT1 23411 Q96EB6 SIRT1 human T344 25594500 GkLLRNYtQNIDTLE SIR2 X -PRKAA1 AMPKA1 Q13131 human NKCC2 6557 Q13621 SLC12A1 human S130 478420 GPKVNRPsLLEIHEQ AA_permease_N X -PRKAA1 AMPKA1 Q13131 human PIAS1 8554 O75925 PIAS1 human S510 14160798 sPVsRtPsLPAVDTS X -PRKAA1 AMPKA1 Q13131 human Tau iso8 4137 P10636-8 MAPT human S262 447930 NVKskIGstENLkHQ Tubulin-binding X -PRKAA1 AMPKA1 Q13131 human PDLIM5 56376 Q8CI51 Pdlim5 mouse S177 38546304 TPLHLSAsGLHVSAN X -PRKAA1 AMPKA1 Q13131 human PPP2R5C 5527 Q13362 PPP2R5C human S298 7643503 KYWPKTHsPKEVMFL B56 X -PRKAA1 AMPKA1 Q13131 human HNF4 alpha 3172 P41235 HNF4A human S313 449926 GkIkRLRsQVQVsLE Hormone_recep X -PRKAA1 AMPKA1 Q13131 human AMPKA1 5562 Q13131 PRKAA1 human T183 448786 sDGEFLRtsCGsPNy Pkinase X X 2535; 2531; 4188; 5256; 50081; 74281 -PRKAA1 AMPKA1 Q13131 human ULK1 22241 O70405 Ulk1 mouse S467 483136 sAIRRsGsttPLGFG X X 4634 -PRKAA1 AMPKA1 Q13131 human CK1E 1454 P49674 CSNK1E human S389 482888 rGAPANVsssDLtGR X -PRKAA1 AMPKA1 Q13131 human HER2 2064 P04626 ERBB2 human T900 41590813 SILRRRFtHQSDVWS PK_Tyr_Ser-Thr X -PRKAA1 AMPKA1 Q13131 human USP10 9100 Q14694 USP10 human S76 3831744 DtLPRtPsySISstL X X -PRKAA1 AMPKA1 Q13131 human Kv1.5 3741 P22460 KCNA5 human S559 1269647505 VQRKVsGsRGSFCKA X X -PRKAA1 AMPKA1 Q13131 human Mnk1 iso2 8569 Q9BUB5-2 MKNK1 human S353 56790200 QVLQRNSsTMDLTLF X X -PRKAA1 AMPKA1 Q13131 human SIRT7 51547 Q9NRC8 SIRT7 human T153 125108501 TLTHMSItRLHEQKL SIR2 X X -PRKAA1 AMPKA1 Q13131 human BRAF iso1 109880 P28028-1 Braf mouse S766 450242 PKIHRSAsEPsLNRA X -PRKAA1 AMPKA1 Q13131 human AMPKB1 5564 Q9Y478 PRKAB1 human T80 7712507 APAQARPtVFRWTGG AMPK1_CBM X -PRKAA1 AMPKA1 Q13131 human Rb 19645 P13405 Rb1 mouse S804 448717 IyIsPLksPyKIsEG Rb_C X 9308; 8974; 4277; 40283; 8957; 8516; 11917; 41359; 75864 -PRKAA1 AMPKA1 Q13131 human FANCA 2175 O15360 FANCA human S347 56793101 VQMQREWsFARtHPL Fanconi_A_N X -PRKAA1 AMPKA1 Q13131 human beclin 1 8678 Q14457 BECN1 human T388 56689904 EEVEKGEtRFCLPYR APG6 X X -PRKAA1 AMPKA1 Q13131 human KLF10 21847 O89091 Klf10 mouse T188 25743268 DNSFRRRtHGNVEAT X -PRKAA1 AMPKA1 Q13131 human Restin 56430 Q922J3 Clip1 mouse S311 4769833 AsLKRsPsAssLSSM X -PRKAA1 AMPKA1 Q13131 human RASAL2 iso2 9462 Q9UJF2-2 RASAL2 human S351 1872043503 TLFARTTsKTKADNI C2 X X -PRKAA1 AMPKA1 Q13131 human DFNA5 1687 O60443 GSDME human T6 50777052 __MFAkAtRNFLREV Gasdermin X X -PRKAA1 AMPKA1 Q13131 human KIF4A 24137 O95239 KIF4A human S801 459849 KLRRRtFsLTEVRGQ X X -PRKAA1 AMPKA1 Q13131 human ChREBP 171078 Q8VIP2 Mlxipl rat S568 451262 TLLRPPEsPDAVPEI X -PRKAA1 AMPKA1 Q13131 human GSDMD 69146 Q9D8T2 Gsdmd mouse S46 1883583906 CLLNRKFsSSRFWKP Gasdermin X X -PRKAA1 AMPKA1 Q13131 human ULK1 8408 O75385 ULK1 human S638 3176158 FDFPKtPssQNLLAL X 14205 -PRKAA1 AMPKA1 Q13131 human FOXO3A 2309 O43524 FOXO3 human S555 20799903 RALsNsVsNMGLSES X X -PRKAA1 AMPKA1 Q13131 human NCL 4691 P19338 NCL human S328 31867151 PELktGIsDVFAkND RRM_1 X X -PRKAA1 AMPKA1 Q13131 human PPP1R3C 5507 Q9UQK1 PPP1R3C human S33 6423500 MRLCLAHsPPVKSFL X -PRKAA1 AMPKA1 Q13131 human AMPKB1 5564 Q9Y478 PRKAB1 human S177 7447522 sQKCsDVsELsssPP X -PRKAA1 AMPKA1 Q13131 human ZNF692 55657 Q9BU19 ZNF692 human S470 471395 VAAHRSKsHPALLLA X -PRKAA1 AMPKA1 Q13131 human HIPK2 28996 Q9H2X6 HIPK2 human T1114 28847906 APAALGStGTVAHLV X -PRKAA1 AMPKA1 Q13131 human Raptor 74370 Q8K4Q0 Rptor mouse S792 2314600 DKMRRVSsYSALNSL X 2083; 89146 -PRKAA1 AMPKA1 Q13131 human TSC2 iso2 24855 P49816-2 Tsc2 rat T1228 450211 PTLPRSNtVASFSSL X X -PRKAA1 AMPKA1 Q13131 human ULK1 22241 O70405 Ulk1 mouse S777 4699310 TRMFsVGsSSsLGST X X -PRKAA1 AMPKA1 Q13131 human CHKA 1119 P35790 CHKA human S279 1876872804 kKLHKLLsYNLPLEL Choline_kinase X -PRKAA1 AMPKA1 Q13131 human eNOS 287024 P29473 NOS3 cow S1179 447884 TSRIRtQsFsLQERH X 9570 -PRKAA1 AMPKA1 Q13131 human p73 7161 O15350 TP73 human S426 33602702 GGMNKLPsVNQLVGQ X X -PRKAA1 AMPKA1 Q13131 human TSC2 7249 P49815 TSC2 human S1387 450212 QPLsKssssPELQtL X X 5584; 23402 -PRKAA1 AMPKA1 Q13131 human Kv2.1 25736 P15387 Kcnb1 rat S444 4714867 ERAKRNGsIVsMNMK X -PRKAA1 AMPKA1 Q13131 human HSL 3991 Q05469 LIPE human S855 448804 EPMRRsVsEAALAQP X X 4137 -PRKAA1 AMPKA1 Q13131 human FOXO3A 2309 O43524 FOXO3 human T179 20799901 SSPDKRLtLSQIyEW Forkhead X X -PRKAA1 AMPKA1 Q13131 human FOXO3A 2309 O43524 FOXO3 human S588 20799904 QTLSDSLsGSSLYST X X -PRKAA1 AMPKA1 Q13131 human CAMKK2 83506 O88831 Camkk2 rat S552 286046003 SPCGGGGsALVKGGP X -PRKAA1 AMPKA1 Q13131 human FOXO3A 2309 O43524 FOXO3 human S30 478738 EPQsRPRsCtWPLQR X -PRKAA1 AMPKA1 Q13131 human TNNI2 29389 P27768 Tnni2 rat S118 4702728 PLRRVRMsADAMLkA Troponin X -PRKAA1 AMPKA1 Q13131 human PNPLA2 66853 Q8BJ56 Pnpla2 mouse S406 473045 VELRRAQsLPsVPLS X X -PRKAA1 AMPKA1 Q13131 human beclin 1 8678 Q14457 BECN1 human S96 472002 MstEsANsFTLIGEA X -PRKAA1 AMPKA1 Q13131 human TBC1D1 57915 Q60949 Tbc1d1 mouse T253 2228805 DASLRSStFssFDND X -PRKAA1 AMPKA1 Q13131 human ZNF9 12785 P53996 Cnbp mouse T173 471955 GHLARECtIEAtA__ zf-CCHC X -PRKAA1 AMPKA1 Q13131 human PPP2R5C 5527 Q13362 PPP2R5C human S336 7643502 RQLAkCVsSPHFQVA B56 X -PRKAA1 AMPKA1 Q13131 human Kir6.2 P70673 Kcnj11 rat S385 2103601 AKPKFSIsPDSLs__ X -PRKAA1 AMPKA1 Q13131 human FOXO3A 2309 O43524 FOXO3 human S413 12084437 GLMQRSSsFPYTTKG X X 8174 -PRKAA1 AMPKA1 Q13131 human GFAT 2673 Q06210 GFPT1 human S261 467935 CNLsRVDsttCLFPV X -PRKAA1 AMPKA1 Q13131 human GATAD2A 234366 Q8CHY6 Gatad2a mouse S96 453704 KSEKRPPsPDVIVLs X -PRKAA1 AMPKA1 Q13131 human TET2 54790 Q6N021 TET2 human S99 3202572 GGIKRtVsEPsLSGL X X -PRKAA1 AMPKA1 Q13131 human EZH2 2146 Q15910 EZH2 human T311 34490427 NtYkRKNtETALDNk X X 27888; 70303 -PRKAA1 AMPKA1 Q13131 human SREBP-1 iso3 6720 P36956-3 SREBF1 human S372 4934079 TAVHKSKsLKDLVSA X X 9874 -PRKAA1 AMPKA1 Q13131 human SCFD1 23256 Q8WVM8 SCFD1 human S316 27461658 PKRKNKksYDLTPVD Sec1 X X -PRKAA1 AMPKA1 Q13131 human GSR 2936 P00390 GSR human T507 23111522 TkADFDNtVAIHPts Pyr_redox_dim X -PRKAA1 AMPKA1 Q13131 human ULK1 8408 O75385 ULK1 human S556 3176155 GLGCRLHsAPNLsDL X 5869 -PRKAA1 AMPKA1 Q13131 human p300 2033 Q09472 EP300 human S89 447592 SELLRSGsSPNLNMG X X -PRKAA1 AMPKA1 Q13131 human CFTR 1080 P13569 CFTR human S768 455300 LQARRRQsVLNLMtH CFTR_R X -PRKAA1 AMPKA1 Q13131 human TBC1D1 23216 Q86TI0 TBC1D1 human T596 1247778 AFRRRANtLsHFPIE X -PRKAA1 AMPKA1 Q13131 human FOXO3A 2309 O43524 FOXO3 human S399 20799902 DNItLPPsQPsPTGG X X -PRKAA1 AMPKA1 Q13131 human genethonin 1 52331 Q8C7E7 Stbd1 mouse S167 469665 SVAAkLPsSSLLVDR X -PRKAA1 AMPKA1 Q13131 human CAMKK2 83506 O88831 Camkk2 rat S126 286046006 RCICPSLsYSPASSP X -PRKAA1 AMPKA1 Q13131 human SKP2 27401 Q9Z0Z3 Skp2 mouse S256 1296362400 ATLLSSCsRLDELNL X X -PRKAA1 AMPKA1 Q13131 human ZDHHC13 54503 Q8IUH4 ZDHHC13 human S208 1880741000 FLLKFNPsLNVVDkI X X -PRKAA1 AMPKA1 Q13131 human CAMKK2 83506 O88831 Camkk2 rat S135 454104 SPASSPQsSPRMPRR X -PRKAA1 AMPKA1 Q13131 human TXNIP 10628 Q9H3M7 TXNIP human S308 277409200 GLssRTssMASRTsS X -PRKAA1 AMPKA1 Q13131 human HDAC5 10014 Q9UQL6 HDAC5 human S259 447995 FPLRkTAsEPNLKVR X X 3443 -PRKAA1 AMPKA1 Q13131 human CAMKK2 83506 O88831 Camkk2 rat S494 469882 KTMIRKRsFGNPFEG X 16737; 35392 -PRKAA1 AMPKA1 Q13131 human KLC1 3831 Q07866 KLC1 human S521 468108 ENMEkRRsREsLNVD X -PRKAA1 AMPKA1 Q13131 human AMPKB1 5564 Q9Y478 PRKAB1 human S24 448111 HKtPRRDssGGtKDG X -PRKAA1 AMPKA1 Q13131 human TBC1D1 57915 Q60949 Tbc1d1 mouse S660 2228809 PRLNPSAssPNFFKY X 6928 -PRKAA1 AMPKA1 Q13131 human ULK1 8408 O75385 ULK1 human S317 35495300 SHLASPPsLGEMQQL X 12753; 37762 -PRKAA1 AMPKA1 Q13131 human DNMT1 iso2 1786 P26358-2 DNMT1 human S730 452655 DNIPEMPsPKKMHQG X X -PRKAA1 AMPKA1 Q13131 human GABBR2 83633 O88871 Gabbr2 rat S783 473060 VTSVNQAsTSRLEGL GBR2_CC X X -PRKAA1 AMPKA1 Q13131 human GAPVD1 26130 Q14C86 GAPVD1 human S902 468085 ErLVRsRssDIVSsV X -PRKAA1 AMPKA1 Q13131 human HSF1 3297 Q00613 HSF1 human S121 455480 NIkRkVtsVSTLksE X X -PRKAA1 AMPKA1 Q13131 human TBC1D1 57915 Q60949 Tbc1d1 mouse T590 1247778 AFRRRANtLsHFPVE X -PRKAA1 AMPKA1 Q13131 human PFKFB3 5209 Q16875 PFKFB3 human S461 448801 NPLMRRNsVtPLAsP X X -PRKAA1 AMPKA1 Q13131 human Kv2.1 25736 P15387 Kcnb1 rat S541 473556 SKMAKTQsQPILNTK Kv2channel X -PRKAA1 AMPKA1 Q13131 human PBEF 10135 P43490 NAMPT human S314 40512819 PLIIRPDsGNPLDTV NAPRTase X X -PRKAA1 AMPKA1 Q13131 human AMPKA1 5562 Q13131 PRKAA1 human S360 7320945 LAtsPPDsFLDDHHL X -PRKAA1 AMPKA1 Q13131 human CGN 57530 Q9P2M7 CGN human S137 457044 GKLLRsHsQAsLAGP X -PRKAA1 AMPKA1 Q13131 human CRY1 12952 P97784 Cry1 mouse S71 11952908 ANLRKLNsRLFVIRG DNA_photolyase X -PRKAA1 AMPKA1 Q13131 human SIRT2 22933 Q8IXJ6 SIRT2 human T101 31839907 PDFRSPStGLyDNLE SIR2 X -PRKAA1 AMPKA1 Q13131 human Oct1 5451 P14859 POU2F1 human S335 10424763 RFEALNLsFKNMCKL Pou X -PRKAA1 AMPKA1 Q13131 human CTBP1 1487 Q13363 CTBP1 human S158 455351 REGTRVQsVEQIREV 2-Hacid_dh_C; 2-Hacid_dh X -PRKAA1 AMPKA1 Q13131 human SKP2 6502 Q13309 SKP2 human S256 1296362400 QTLLSSCsRLDELNL X X -PRKAA1 AMPKA1 Q13131 human NKCC1 6558 P55011 SLC12A2 human S77 3192079 RPLGPtPsQsRFQVD X X -PRKAA1 AMPKA1 Q13131 human TBC1D1 23216 Q86TI0 TBC1D1 human S237 2103609 RPMRKsFsQPGLRSL X X -PRKAA1 AMPKA1 Q13131 human p27Kip1 12576 P46414 Cdkn1b mouse T197 448781 KPGLRRQt_______ X -PRKAA1 AMPKA1 Q13131 human MED1 19014 Q925J9 Med1 mouse S811 28758703 GtPVRDSsSSGHSQS X -PRKAA1 AMPKA1 Q13131 human Cortactin 2017 Q14247 CTTN human T401 449245 QARAKtQtPPVsPAP X X -PRKAA1 AMPKA1 Q13131 human SCFD1 23256 Q8WVM8 SCFD1 human S303 3207654 EssGVENsPAGARPK Sec1 X X -PRKAA1 AMPKA1 Q13131 human NKCC1 6558 P55011 SLC12A2 human S242 18912156 GEkLLRPsLAELHDE AA_permease_N X X -PRKAA1 AMPKA1 Q13131 human PD-L1 29126 Q9NZQ7 CD274 human S195 796148000 EKLFNVtsTLRINTT C2-set_2 X X -PRKAA1 AMPKA1 Q13131 human BRAF 673 P15056 BRAF human S729 450242 PKIHRSAsEPsLNRA X X -PRKAA1 AMPKA1 Q13131 human NRF2 4780 Q16236 NFE2L2 human S433 27461383 PEKELPVsPGHrktP X X -PRKAA1 AMPKA1 Q13131 human Tau iso8 4137 P10636-8 MAPT human S422 449083 GsIDMVDsPQLAtLA X -PRKAA1 AMPKA1 Q13131 human EGLN1 54583 Q9GZT9 EGLN1 human S136 1877121600 AAAGGQGsAVAAEAE X X -PRKAA1 AMPKA1 Q13131 human SCN5A 6331 Q14524 SCN5A human T101 1867858201 IVLNKGKtIFRFSAT X X -PRKAA1 AMPKA1 Q13131 human GABBR1 81657 Q9Z0U4 Gabbr1 rat S948 473059 ELRHQLQsRQQLRSR X -PRKAA1 AMPKA1 Q13131 human AMPKB1 5564 Q9Y478 PRKAB1 human T148 7447514 IVTsQLGtVNNIIQV AMPK1_CBM X -PRKAA1 AMPKA1 Q13131 human ULK1 22241 O70405 Ulk1 mouse S555 3176155 GLGCRLHsAPNLSDF X X 5869 -PRKAA1 AMPKA1 Q13131 human TNNI3 7137 P19429 TNNI3 human S150 451822 tLRrVrIsADAMMQA Troponin X X -PRKAA1 AMPKA1 Q13131 human HAT1 8520 O14929 HAT1 human S190 63080404 MWFIETAsFIDVDDE X X -PRKAA1 AMPKA1 Q13131 human CFTR 1080 P13569 CFTR human S813 449983 DIYsRRLsQEtGLEI CFTR_R X X -PRKAA1 AMPKA1 Q13131 human FOXO1A 2308 Q12778 FOXO1 human T649 35486505 PHSVKTttHsWVsG_ X X -PRKAA1 AMPKA1 Q13131 human beclin 1 8678 Q14457 BECN1 human S90 472001 IPPARMMstEsANsF X 29362; 86455 -PRKAA1 AMPKA1 Q13131 human GAPVD1 66691 Q6PAR5 Gapvd1 mouse S902 468085 ERLVRsRssDIVSsV X -PRKAA1 AMPKA1 Q13131 human CAMKK2 83506 O88831 Camkk2 rat S174 286046000 KDEIGKGsYGVVKLA Pkinase X -PRKAA1 AMPKA1 Q13131 human NEDD4L 23327 Q96PU5 NEDD4L human S795 18963100 VDLKPNGsEIMVTNE HECT X -PRKAA1 AMPKA1 Q13131 human INSIG1 3638 O15503 INSIG1 human T222 1868139204 ItIAFLAtLITQFLV TM; INSIG X -PRKAA1 AMPKA1 Q13131 human Raptor 57521 Q8N122 RPTOR human S722 2314601 PrLrsVssyGNIRAV X -PRKAA1 AMPKA1 Q13131 human FOXO1A 2308 Q12778 FOXO1 human S22 1869008600 EPLPRPRsCtWPLPR X -PRKAA1 AMPKA1 Q13131 human Syk 6850 P43405 SYK human S178 25687503 GKISREEsEQIVLIG SH2 X -PRKAA1 AMPKA1 Q13131 human ACSS2 55902 Q9NR19 ACSS2 human S659 83970101 PGLPKTRsGKIMRRV AMP-binding_C X -PRKAA1 AMPKA1 Q13131 human TNNI3 7137 P19429 TNNI3 human S24 448424 APIRRRssNyRAyAt Troponin-I_N X 4004 -PRKAA1 AMPKA1 Q13131 human DBC-1 57805 Q8N163 CCAR2 human S808 9426781 ALVsHNGsLINVGsL X X -PRKAA1 AMPKA1 Q13131 human JAK1 3716 P23458 JAK1 human S515 62372200 SLHGSDRsFPsLGDL X -PRKAA1 AMPKA1 Q13131 human TSC2 24855 P49816 Tsc2 rat S1389 450212 QPLsKSSsSPELQTL X 5584; 23402 -PRKAA1 AMPKA1 Q13131 human HSL 16890 P54310 Lipe mouse S559 448804 ESMRRsVsEAALAQP X X 4137 -PRKAA1 AMPKA1 Q13131 human PDE4D iso6 24627 P14270-6 Pde4d rat S81 33670300 KSMSRNSsIASDIHG X -PRKAA1 AMPKA1 Q13131 human smMLCK 396445 P11799 MYLK chicken S1749 466361 RAIGRLSsMAMISGM X -PRKAA1 AMPKA1 Q13131 human CYCS 510767 P62894 CYCS cow T29 4710693 EkGGkHktGPNLHGL Cytochrom_C X -PRKAA1 AMPKA1 Q13131 human ACC2 32 O00763 ACACB human S222 448808 PtMRPsMsGLHLVKR X 3661; 11818; 42801 -PRKAA1 AMPKA1 Q13131 human NR2C2 22026 P49117 Nr2c2 mouse S351 7990482 HVISRDQstPIIEVE X X -PRKAA1 AMPKA1 Q13131 human SQSTM1 8878 Q13501 SQSTM1 human S294 31872178 ssCCsDPskPGGNVE X -PRKAA1 AMPKA1 Q13131 human MAP4 17758 P27546 Map4 mouse S914 1210622 SVRsKVGstENIKHQ Tubulin-binding X -PRKAA1 AMPKA1 Q13131 human KCNMA1 iso4 16531 Q08460-4 Kcnma1 mouse S722 18264900 GRSERDCsCMSGRVR X -CDK12 CDK12 Q9NYV4 human PAK2 5062 Q13177 PAK2 human T134 15413019 LkFyDsNtVkQKyLs X X -CDK12 CDK12 Q9NYV4 human POLR2A 5430 P24928 POLR2A human S1616 450204 TPQSPSysPtsPsYS RNA_pol_Rpb1_R X X 4735; 13499; 13546; 31262 -CDK12 CDK12 Q9NYV4 human PAK2 5062 Q13177 PAK2 human T169 471473 TEAPAVVtEEEDDDE X X -CDK12 CDK12 Q9NYV4 human p63 iso2 8626 Q9H3D4-2 TP63 human S68 451601 TFDALsPsPAIPSNT X -CDK12 CDK12 Q9NYV4 human POLR2A 5430 P24928 POLR2A human S1619 447616 SPSysPtsPsYSPTS RNA_pol_Rpb1_R X 4735; 13523; 13546; 67221 -CDK12 CDK12 Q9NYV4 human p63 iso2 8626 Q9H3D4-2 TP63 human S66 451600 SSTFDALsPsPAIPS X -CDK12 CDK12 Q9NYV4 human p63 iso2 8626 Q9H3D4-2 TP63 human S301 451602 TSIKKRRsPDDELLY P53_tetramer X -CAMK4 CAMK4 Q16566 human QIK 315649 Q3LRT3 Sik2 rat T484 478056 RSGQRRHtLSEVTNQ X -CAMK4 CAMK4 Q16566 human HDAC5 10014 Q9UQL6 HDAC5 human S498 447996 RPLSRtQsSPLPQsP X X 3424 -CAMK4 CAMK4 Q16566 human CREB 1385 P16220 CREB1 human S119 448228 EILsRRPsyRkILND pKID X 9187; 9196; 9198; 4095; 14228; 14001; 39561; 80120; 44864; 54960; 95995 -CAMK4 CAMK4 Q16566 human hnRNP L 3191 P14866 HNRNPL human S544 15436636 GkSERSssGLLEWES X X -CAMK4 CAMK4 Q16566 human CBP 54244 Q6JHU9 Crebbp rat S301 448068 PQLASKQsMVNSLPA X X -CAMK4 CAMK4 Q16566 human NOVA2 4858 Q9UNW9 NOVA2 human T27 1869341902 VCTKRsNtGEEGEYF X -CAMK4 CAMK4 Q16566 human NOVA2 4858 Q9UNW9 NOVA2 human S194 1869341903 EQVHKAVsAIVQKVQ KH_1 X -CAMK4 CAMK4 Q16566 human CBP 12914 P45481 Crebbp mouse S301 448068 PQLASKQsMVNSLPA X X -CAMK4 CAMK4 Q16566 human BAP37 11331 Q99623 PHB2 human S91 22342307 RARPRkIssPTGSkD Band_7 X X -CAMK4 CAMK4 Q16566 human CREB iso1 81646 P15337-1 Creb1 rat S133 448228 EILsRRPsYRkILND pKID X 9187; 9196; 9198; 4095; 14228; 14001; 39561; 80120; 44864; 54960; 95995 -CAMK4 CAMK4 Q16566 human CAMK2A iso2 815 Q9UQM7-2 CAMK2A human S332 3143902 DGVKkRKssssVQLM X -CAMK4 CAMK4 Q16566 human NFkB-p65 5970 Q04206 RELA human S536 447800 sGDEDFSsIADMDFS X 4887; 3036; 3031; 4886; 3033; 4025; 5733; 13346; 76778; 31553; 80477; 73992; 87672; 83962 -CAMK4 CAMK4 Q16566 human NOVA2 4858 Q9UNW9 NOVA2 human S25 1869341901 EVVCTKRsNtGEEGE X -CAMK4 CAMK4 Q16566 human HDAC5 10014 Q9UQL6 HDAC5 human S259 447995 FPLRkTAsEPNLKVR X X 3443 -CAMK4 CAMK4 Q16566 human STMN1 3925 P16949 STMN1 human S16 448554 kELEKrAsGQAFELI Stathmin X 3353 -CAMK4 CAMK4 Q16566 human MYH9 25745 Q62812 Myh9 rat T1940 452194 RRIVRKGtGDCsDEE X -GSK3B GSK3B G1T8E2 rabbit GSK3B 84027 P18266 Gsk3b rat S9 449111 SGRPRTTsFAESCKP X 9336; 9331; 9327; 9323; 9322; 9325; 5558; 8566; 79774; 8466; 25462; 14026; 14332; 14310; 14630 -GSK3B GSK3B G1T8E2 rabbit HSL 25330 P15304 Lipe rat S865 448804 ESMRRsVsEAALAQP X 4137 -GSK3B GSK3B G1T8E2 rabbit GYS1 100008660 P13834 GYS1 rabbit S649 448239 VPPsPSLsRHSsPHQ Glycogen_syn X -GSK3B GSK3B G1T8E2 rabbit SCN2A 24766 P04775 Scn2a rat T1966 4692783 TPEKtDVtPsttsPP X -GSK3B GSK3B G1T8E2 rabbit GYS1 100008660 P13834 GYS1 rabbit S641 448237 YRYPRPAsVPPsPSL Glycogen_syn X -GSK3B GSK3B G1T8E2 rabbit GYS1 100008660 P13834 GYS1 rabbit S645 448238 RPAsVPPsPSLsRHS Glycogen_syn X -GSK3B GSK3B G1T8E2 rabbit VHL 7428 P40337 VHL human S68 469116 PVLRSVNsREPsQVI VHL X -GSK3B GSK3B G1T8E2 rabbit IRF1 16362 P15314 Irf1 mouse T181 1380568700 LDMERDItPALsPCV X -GSK3B GSK3B G1T8E2 rabbit GYS1 100008660 P13834 GYS1 rabbit S653 448240 PSLsRHSsPHQsEDE Glycogen_syn X -GSK3B GSK3B G1T8E2 rabbit FGF14 2259 Q92915 FGF14 human S226 93432000 PkPGVTPsKsTsASA X -PRKAA2 AMPKA2 P54646 human p53 22059 P02340 Tp53 mouse S18 447490 IsLELPLsQEtFsGL P53_TAD X 9284; 9286; 12571; 56979 -PRKAA2 AMPKA2 P54646 human REEP1 65055 Q9H902 REEP1 human S152 454487 SERLRsFsMQDLTTI X -PRKAA2 AMPKA2 P54646 human PLD1 5337 Q13393 PLD1 human S505 11091057 GsVkRVTsGPsLGSL X X -PRKAA2 AMPKA2 P54646 human HDAC5 10014 Q9UQL6 HDAC5 human S498 447996 RPLSRtQsSPLPQsP X 3424 -PRKAA2 AMPKA2 P54646 human HIPK2 28996 Q9H2X6 HIPK2 human S121 28847902 LMRRStVsLLDTYQK X -PRKAA2 AMPKA2 P54646 human ACC1 31 Q13085 ACACA human S80 448292 LHIRssMsGLHLVkQ X X 3661; 11818; 42801 -PRKAA2 AMPKA2 P54646 human 53BP1 7158 Q12888 TP53BP1 human S1317 476252 SSLHRtssGtsLSAM X X -PRKAA2 AMPKA2 P54646 human TBC1D1 57915 Q60949 Tbc1d1 mouse S231 2103609 RPMRKsFsQPGLRSL X -PRKAA2 AMPKA2 P54646 human HIPK2 28996 Q9H2X6 HIPK2 human T119 28847903 HNLMRRStVsLLDTY X -PRKAA2 AMPKA2 P54646 human PARP1 142 P09874 PARP1 human S177 18013484 LGFRPEYsAsQLkGF zf-PARP X -PRKAA2 AMPKA2 P54646 human PDHA1 5160 P08559 PDHA1 human S314 1868287349 IQEVRSksDPIMLLk E1_dh X -PRKAA2 AMPKA2 P54646 human EEF2K 29904 O00418 EEF2K human S398 450686 DsLPssPssAtPHSQ X -PRKAA2 AMPKA2 P54646 human DUSP1 1843 P28562 DUSP1 human S334 53736000 AVLDRGTsTTTVFNF X X -PRKAA2 AMPKA2 P54646 human CDC27 996 P30260 CDC27 human S379 5965291 NALPRRssRLFtsDs X X -PRKAA2 AMPKA2 P54646 human ACC1 107476 Q5SWU9 Acaca mouse S79 448292 FHMRSsMsGLHLVKQ X 3661; 11818; 42801 -PRKAA2 AMPKA2 P54646 human PGC-1 alpha 19017 O70343 Ppargc1a mouse S538 486320 SLFDVSPsCSSFNSP X -PRKAA2 AMPKA2 P54646 human FOXO3A 2309 O43524 FOXO3 human S626 20799905 SLECDMEsIIRSELM FOXO-TAD X -PRKAA2 AMPKA2 P54646 human PARP1 11545 P11103 Parp1 mouse S177 18013484 LGFRPEYsASQLKGF zf-PARP X -PRKAA2 AMPKA2 P54646 human GLI1 2735 P08151 GLI1 human S408 41595600 GPLPRAPsISTVEPk X X -PRKAA2 AMPKA2 P54646 human DYNC1I2 13427 O88487 Dync1i2 mouse S81 449148 PIVPPPMsPssKsVs X -PRKAA2 AMPKA2 P54646 human PPP1R12C 54776 Q9BZL4 PPP1R12C human S452 472608 AGLQRsAsssWLEGt X X -PRKAA2 AMPKA2 P54646 human PINK1 65018 Q9BXM7 PINK1 human S228 25792200 MWNISAGsSSEAILN X 89010; 46421 -PRKAA2 AMPKA2 P54646 human HOXB9 15417 P20615 Hoxb9 mouse T133 31087958 GELLKQGtPEYSLET Hox9_act X X -PRKAA2 AMPKA2 P54646 human PDHA1 5160 P08559 PDHA1 human S295 468391 RyHGHsMsDPGVsyR E1_dh X -PRKAA2 AMPKA2 P54646 human RAG1 19373 P15919 Rag1 mouse S528 28076402 PPLKNVSsRTDVGII RAG1 X X -PRKAA2 AMPKA2 P54646 human Raptor 57521 Q8N122 RPTOR human S792 2314600 DKMRRAssYSsLNSL X 2083; 89146 -PRKAA2 AMPKA2 P54646 human ARK2N 212163 Q8BH50 Ark2n mouse S67 485212 MELRRDssEsQLAst RNF111_N X -PRKAA2 AMPKA2 P54646 human SIRT1 23411 Q96EB6 SIRT1 human T344 25594500 GkLLRNYtQNIDTLE SIR2 X -PRKAA2 AMPKA2 P54646 human PINK1 65018 Q9BXM7 PINK1 human S495 396518801 ALLQREAsKRPSARV Pkinase X -PRKAA2 AMPKA2 P54646 human KLF10 21847 O89091 Klf10 mouse T188 25743268 DNSFRRRtHGNVEAT X X -PRKAA2 AMPKA2 P54646 human Restin 56430 Q922J3 Clip1 mouse S311 4769833 AsLKRsPsAssLSSM X -PRKAA2 AMPKA2 P54646 human DFNA5 1687 O60443 GSDME human T6 50777052 __MFAkAtRNFLREV Gasdermin X -PRKAA2 AMPKA2 P54646 human PHF2 5253 O75151 PHF2 human S655 3175945 kALRPPtsPGVFGAL X -PRKAA2 AMPKA2 P54646 human HAS2 3037 Q92819 HAS2 human T110 18122801 LQSVKRLtYPGIKVV X -PRKAA2 AMPKA2 P54646 human GSDMD 69146 Q9D8T2 Gsdmd mouse S46 1883583906 CLLNRKFsSSRFWKP Gasdermin X X -PRKAA2 AMPKA2 P54646 human FOXO3A 2309 O43524 FOXO3 human S555 20799903 RALsNsVsNMGLSES X -PRKAA2 AMPKA2 P54646 human HIPK2 28996 Q9H2X6 HIPK2 human T1114 28847906 APAALGStGTVAHLV X -PRKAA2 AMPKA2 P54646 human CHKA 1119 P35790 CHKA human S279 1876872804 kKLHKLLsYNLPLEL Choline_kinase X -PRKAA2 AMPKA2 P54646 human Kv2.1 25736 P15387 Kcnb1 rat S444 4714867 ERAKRNGsIVsMNMK X -PRKAA2 AMPKA2 P54646 human VASP 22323 P70460 Vasp mouse S317 469024 TtLPRMKssssVtTS X -PRKAA2 AMPKA2 P54646 human FOXO3A 2309 O43524 FOXO3 human T179 20799901 SSPDKRLtLSQIyEW Forkhead X -PRKAA2 AMPKA2 P54646 human FOXO3A 2309 O43524 FOXO3 human S588 20799904 QTLSDSLsGSSLYST X -PRKAA2 AMPKA2 P54646 human PROX1 5629 Q92786 PROX1 human S79 487308 KLLKRANsyEDAMMP X X -PRKAA2 AMPKA2 P54646 human PINK1 65018 Q9BXM7 PINK1 human S284 396518802 VLRAFTSsVPLLPGA Pkinase X -PRKAA2 AMPKA2 P54646 human IRSp53 10458 Q9UQB8 BAIAP2 human S366 468035 ktLPRsssMAAGLER X X -PRKAA2 AMPKA2 P54646 human FOXO3A 2309 O43524 FOXO3 human S413 12084437 GLMQRSSsFPYTTKG X 8174 -PRKAA2 AMPKA2 P54646 human AMPKA2 5563 P54646 PRKAA2 human T172 448026 sDGEFLRtsCGsPNy Pkinase X 2535; 2531; 5256; 50081; 74281 -PRKAA2 AMPKA2 P54646 human KLC4 89953 Q9NSK0 KLC4 human S590 454355 SNMKRAAsLNyLNQP X -PRKAA2 AMPKA2 P54646 human PAK2 5062 Q13177 PAK2 human S20 448298 APPVRMsstIFstGG X X 2607 -PRKAA2 AMPKA2 P54646 human IKKB 3551 O14920 IKBKB human S177 447492 AkELDQGsLCtsFVG Pkinase X X 2078; 2697; 2694; 14938; 92255; 36516; 36214 -PRKAA2 AMPKA2 P54646 human PGC-1 alpha 19017 O70343 Ppargc1a mouse T177 486319 NHTHRIRtNPAIVkT X -PRKAA2 AMPKA2 P54646 human REEP2 51308 Q9BRK0 REEP2 human S150 4765340 SEkLRsFsMQDLTLI X -PRKAA2 AMPKA2 P54646 human TBC1D1 23216 Q86TI0 TBC1D1 human T596 1247778 AFRRRANtLsHFPIE X -PRKAA2 AMPKA2 P54646 human FOXO3A 2309 O43524 FOXO3 human S399 20799902 DNItLPPsQPsPTGG X -PRKAA2 AMPKA2 P54646 human AS160 210789 Q8BYJ6 Tbc1d4 mouse S711 2226513 PSLHTSFsAPSFTAP X -PRKAA2 AMPKA2 P54646 human HDAC5 10014 Q9UQL6 HDAC5 human S259 447995 FPLRkTAsEPNLKVR X 3443 -PRKAA2 AMPKA2 P54646 human GLI1 2735 P08151 GLI1 human S102 41595602 LQTVIRTsPSSLVAF X X -PRKAA2 AMPKA2 P54646 human IKKB 3551 O14920 IKBKB human S181 447489 DQGsLCtsFVGTLQy Pkinase X X 2697; 2694; 14938; 92255; 36516; 36214 -PRKAA2 AMPKA2 P54646 human Kv2.1 25736 P15387 Kcnb1 rat S541 473556 SKMAKTQsQPILNTK Kv2channel X -PRKAA2 AMPKA2 P54646 human AP-2 alpha 7020 P05549 TFAP2A human S219 25581601 CSVPGRLsLLSsTsk TF_AP-2 X X -PRKAA2 AMPKA2 P54646 human AMPKA2 108079 Q8BRK8 Prkaa2 mouse T172 448026 sDGEFLRtsCGsPNY Pkinase X 2535; 2531; 5256; 50081; 74281 -PRKAA2 AMPKA2 P54646 human ACE2 70008 Q8R0I0 Ace2 mouse S680 1868162500 SDLKPRVsFYFFVTS Collectrin X X -PRKAA2 AMPKA2 P54646 human TBC1D1 23216 Q86TI0 TBC1D1 human S237 2103609 RPMRKsFsQPGLRSL X -PRKAA2 AMPKA2 P54646 human MFF 56947 Q9GZY8 MFF human S172 484865 GQLVRNDsLWHRsDs Miff X -PRKAA2 AMPKA2 P54646 human Myc 4609 P01106 MYC human S82 4967400 PLsPsRRsGLCsPSy Myc_N X X -PRKAA2 AMPKA2 P54646 human beclin 1 56208 O88597 Becn1 mouse S94 472002 MsTEsANsFTLIGEA X -PRKAA2 AMPKA2 P54646 human GLI1 2735 P08151 GLI1 human T1074 41595601 QRGSsGHtPPPsGPP X X 35875 -PRKAA2 AMPKA2 P54646 human ARMC10 83787 Q8N2F6 ARMC10 human S45 454558 LGIRSsKsAGALEEG X X -STK38L NDR2 Q9Y2H1 human IRF3 3661 Q14653 IRF3 human S396 449028 NtVDLHIsNsHPLsL X X 4947; 29047; 83611; 10327; 53539; 81093; 52270; 61166 -STK38L NDR2 Q9Y2H1 human NuaK1 9891 O60285 NUAK1 human T211 456032 QKDKFLQtFCGSPLY Pkinase X -STK38L NDR2 Q9Y2H1 human RAB3IP 117177 Q96QF0 RAB3IP human S288 4734219 KGHTRNKstSSAMSG X -STK38L NDR2 Q9Y2H1 human YAP1 10413 P46937 YAP1 human S127 448847 PQHVRAHssPAsLQL X 4911; 13008; 92367; 57706 -STK38L NDR2 Q9Y2H1 human ULK1 8408 O75385 ULK1 human S495 6220991 GVLARKMsLGGGRPY X X -STK38L NDR2 Q9Y2H1 human NDR2 23012 Q9Y2H1 STK38L human S282 460298 NRRQLAYstVGtPDy Pkinase X -CDC42BPB MRCKB Q9Y5S2 human MRCKB 9578 Q9Y5S2 CDC42BPB human T1108 1870421700 HVKVPKPtGVKKGWQ X -CDC42BPB MRCKB Q9Y5S2 human SIAH2 6478 O43255 SIAH2 human S6 25172963 __MsRPSstGPsANk X -CDC42BPB MRCKB Q9Y5S2 human SIAH2 6478 O43255 SIAH2 human T279 1872043500 RRLTWEAtPRSIHDG Sina X -Pim2 Pim2 Q62070 mouse NOTCH3 18131 Q61982 Notch3 mouse S1673 11179168 ARRKREHsTLWFPEG X -Wee2 WEE1B Q66JT0 mouse CDK1 12534 P11440 Cdk1 mouse Y15 447610 EKIGEGtyGVVyKGR Pkinase X 4539; 9111; 14566; 77897 -Prkaa1 AMPKA1 Q5EG47 mouse RAF1 5894 P04049 RAF1 human S621 447746 PKINRsAsEPsLHRA X -Prkaa1 AMPKA1 Q5EG47 mouse beclin 1 56208 O88597 Becn1 mouse S91 5473540 ARMMsTEsANsFTLI X 14717 -Prkaa1 AMPKA1 Q5EG47 mouse MFF iso4 75734 Q6PCP5-4 Mff mouse S129 470753 GRLKRERsMsENAVR Miff X -Prkaa1 AMPKA1 Q5EG47 mouse PDE4B 18578 Q8VBU5 Pde4b mouse S304 4765135 KKLMHsssLNNtSIS X -Prkaa1 AMPKA1 Q5EG47 mouse Raptor 74370 Q8K4Q0 Rptor mouse S722 2314601 PRLRsVssyGNIRAV X -Prkaa1 AMPKA1 Q5EG47 mouse TNNI3 21954 P48787 Tnni3 mouse S151 451822 tLRRVRIsADAMMQA Troponin X -Prkaa1 AMPKA1 Q5EG47 mouse H2B 319187 P10853 H2bc15 mouse S36 449903 RKRsRkEsysVyVyk Histone X -Prkaa1 AMPKA1 Q5EG47 mouse TBC1D1 57915 Q60949 Tbc1d1 mouse S700 2228807 KKLHssssVPNFLKF X 6929 -Prkaa1 AMPKA1 Q5EG47 mouse GABBR2 242425 Q80T41 Gabbr2 mouse S783 473060 VtsVNQAsTSRLEGL GBR2_CC X -Prkaa1 AMPKA1 Q5EG47 mouse TBC1D1 57915 Q60949 Tbc1d1 mouse S231 2103609 RPMRKsFsQPGLRSL X -Prkaa1 AMPKA1 Q5EG47 mouse TSC2 22084 Q61037 Tsc2 mouse S1388 450212 QPLSKssssPELQTL X 5584; 23402 -Prkaa1 AMPKA1 Q5EG47 mouse TBC1D1 57915 Q60949 Tbc1d1 mouse T499 2228808 NRAKRsLtEsLEsIL X -Prkaa1 AMPKA1 Q5EG47 mouse SIRT7 209011 Q8BKJ9 Sirt7 mouse T264 1874512900 EAAsKADtILCLGSS SIR2 X -Prkaa1 AMPKA1 Q5EG47 mouse TNNI3 29248 P23693 Tnni3 rat S151 451822 tLRRVRIsADAMMQA Troponin X -Prkaa1 AMPKA1 Q5EG47 mouse ACC1 107476 Q5SWU9 Acaca mouse S79 448292 FHMRSsMsGLHLVKQ X 3661; 11818; 42801 -Prkaa1 AMPKA1 Q5EG47 mouse EXO1 9156 Q9UQ84 EXO1 human S746 1240803 PGLYkSSsADsLStT X -Prkaa1 AMPKA1 Q5EG47 mouse TET2 214133 Q4JK59 Tet2 mouse S97 3202572 GGIKRtVsEPSLsGL X -Prkaa1 AMPKA1 Q5EG47 mouse GFAT 14583 P47856 Gfpt1 mouse S259 467935 CGLsRVDsttCLFPV X X -Prkaa1 AMPKA1 Q5EG47 mouse PAK2 224105 Q8CIN4 Pak2 mouse S20 448298 APPVRMSstIFSTGG X -Prkaa1 AMPKA1 Q5EG47 mouse PIKFYVE 18711 Q9Z1T6 Pikfyve mouse S307 457532 PARNRsAsItNLsLD X X -Prkaa1 AMPKA1 Q5EG47 mouse TBC1D1 57915 Q60949 Tbc1d1 mouse S621 2228806 RKLMRYHsVstETPH X -Prkaa1 AMPKA1 Q5EG47 mouse KLC1 16593 O88447 Klc1 mouse S520 468108 EsMEKRRsREsLNMD X -Prkaa1 AMPKA1 Q5EG47 mouse PIKFYVE 18711 Q9Z1T6 Pikfyve mouse S48 3887627 PFKSAYSsFVNLFRF X -Prkaa1 AMPKA1 Q5EG47 mouse NUDT14 66174 Q9D142 Nudt14 mouse T141 41294000 TDLRRVAtYMSGVGL NUDIX X -Prkaa1 AMPKA1 Q5EG47 mouse MFF iso4 75734 Q6PCP5-4 Mff mouse S146 484865 GQLVRNDsMyGIsNL Miff; Miff X 49281 -Prkaa1 AMPKA1 Q5EG47 mouse SMURF1 75788 Q9CUN6 Smurf1 mouse S148 27460454 DRIGGGGsVVDCRGL X X -Prkaa1 AMPKA1 Q5EG47 mouse PDLIM5 56376 Q8CI51 Pdlim5 mouse S177 38546304 TPLHLSAsGLHVSAN X -Prkaa1 AMPKA1 Q5EG47 mouse CK1E 1454 P49674 CSNK1E human S389 482888 rGAPANVsssDLtGR X -Prkaa1 AMPKA1 Q5EG47 mouse TNNI3 21954 P48787 Tnni3 mouse S23 448423 PAPVRRRssANyRAY Troponin-I_N X -Prkaa1 AMPKA1 Q5EG47 mouse Rb 19645 P13405 Rb1 mouse S804 448717 IyIsPLksPyKIsEG Rb_C X 9308; 8974; 4277; 40283; 8957; 8516; 11917; 41359; 75864 -Prkaa1 AMPKA1 Q5EG47 mouse KLF10 21847 O89091 Klf10 mouse T188 25743268 DNSFRRRtHGNVEAT X -Prkaa1 AMPKA1 Q5EG47 mouse TNNI3 29248 P23693 Tnni3 rat S23 448423 PAPVRRRssANYRAY Troponin-I_N X 4004 -Prkaa1 AMPKA1 Q5EG47 mouse Raptor 74370 Q8K4Q0 Rptor mouse S792 2314600 DKMRRVSsYSALNSL X 2083; 89146 -Prkaa1 AMPKA1 Q5EG47 mouse TBC1D17 233204 Q8BYH7 Tbc1d17 mouse S168 1873559800 RALLRVLsRYLLLAS PH_RBD X X -Prkaa1 AMPKA1 Q5EG47 mouse PNPLA2 66853 Q8BJ56 Pnpla2 mouse S406 473045 VELRRAQsLPsVPLS X -Prkaa1 AMPKA1 Q5EG47 mouse AS160 210789 Q8BYJ6 Tbc1d4 mouse S595 455920 RMRGRLGsMDsFERA X 8730 -Prkaa1 AMPKA1 Q5EG47 mouse TNNI3 29248 P23693 Tnni3 rat S24 448424 APVRRRssANYRAYA Troponin-I_N X 4004 -Prkaa1 AMPKA1 Q5EG47 mouse AS160 210789 Q8BYJ6 Tbc1d4 mouse S764 3175636 sstCsNEsLNAGGtP X -Prkaa1 AMPKA1 Q5EG47 mouse TBC1D1 57915 Q60949 Tbc1d1 mouse T253 2228805 DASLRSStFssFDND X -Prkaa1 AMPKA1 Q5EG47 mouse RAF1 5894 P04049 RAF1 human S259 447741 sQRQRststPNVHMV X 9421; 20011 -Prkaa1 AMPKA1 Q5EG47 mouse ZNF9 12785 P53996 Cnbp mouse T173 471955 GHLARECtIEAtA__ zf-CCHC X -Prkaa1 AMPKA1 Q5EG47 mouse MFF 75734 Q6PCP5 Mff mouse S129 470753 GRLKRERsMsENAVR Miff X -Prkaa1 AMPKA1 Q5EG47 mouse MFF 75734 Q6PCP5 Mff mouse S146 484865 GQLVRNDsIVtPsPP Miff X 49281 -Prkaa1 AMPKA1 Q5EG47 mouse AS160 210789 Q8BYJ6 Tbc1d4 mouse S711 2226513 PSLHTSFsAPSFTAP X -Prkaa1 AMPKA1 Q5EG47 mouse TBC1D1 57915 Q60949 Tbc1d1 mouse S660 2228809 PRLNPSAssPNFFKY X 6928 -Prkaa1 AMPKA1 Q5EG47 mouse TBC1D1 57915 Q60949 Tbc1d1 mouse T590 1247778 AFRRRANtLsHFPVE X -Prkaa1 AMPKA1 Q5EG47 mouse CYCS 13063 P62897 Cycs mouse T29 4710693 EKGGKHktGPNLHGL Cytochrom_C X -Prkaa1 AMPKA1 Q5EG47 mouse NKCC2 20495 P55014 Slc12a1 mouse S126 478420 GPkVNRPsLLEIHEQ AA_permease_N X X -Prkaa1 AMPKA1 Q5EG47 mouse GCKR 231103 Q91X44 Gckr mouse S481 1873175600 QKFQRELsTKWVLNT X X -Prkaa1 AMPKA1 Q5EG47 mouse H2B 3018 P33778 H2BC3 human S36 449903 RKRsRkEsysIyVyk Histone X -Prkaa1 AMPKA1 Q5EG47 mouse ULK1 22241 O70405 Ulk1 mouse S555 3176155 GLGCRLHsAPNLSDF X 5869 -Prkaa1 AMPKA1 Q5EG47 mouse girdin 108686 Q5SNZ0 Ccdc88a mouse S245 4725941 PGMKRTEsRQHLSVE X -Prkaa1 AMPKA1 Q5EG47 mouse AS160 210789 Q8BYJ6 Tbc1d4 mouse S348 455922 QPRRRHAsAPsHVQP PID X -Prkaa1 AMPKA1 Q5EG47 mouse HSL 16890 P54310 Lipe mouse S559 448804 ESMRRsVsEAALAQP X 4137 -Prkaa1 AMPKA1 Q5EG47 mouse MAP4 17758 P27546 Map4 mouse S914 1210622 SVRsKVGstENIKHQ Tubulin-binding X -Prkaa1 AMPKA1 Q5EG47 mouse AS160 210789 Q8BYJ6 Tbc1d4 mouse S577 455923 AKRsLtssLENIFSr X -CSNK1E CK1E P49674 human PER2 8864 O15055 PER2 human S662 449331 ALPGKAEsVAsLTsQ X X -CSNK1E CK1E P49674 human TDP-43 23435 Q13148 TARDBP human S379 3084615 NSYsGsNsGAAIGWG X X -CSNK1E CK1E P49674 human DVL3 1857 Q92997 DVL3 human S311 25736748 EINFENMsNDDAVRV PDZ X -CSNK1E CK1E P49674 human Snail1 6615 O95863 SNAI1 human S104 455881 GkGsQPPsPPsPAPs X -CSNK1E CK1E P49674 human E4BP4 395326 Q90Z72 NFIL3 chicken S182 452016 CISVIKHsPQSSMSD Vert_IL3-reg_TF X X -CSNK1E CK1E P49674 human TRPM4 54795 Q8TD43 TRPM4 human S839 36400700 GLSGGGGsLASGGPG Ion_trans X -CSNK1E CK1E P49674 human MCR 4306 P08235 NR3C2 human T800 1875398904 LPLEDQItLIQYSWM Hormone_recep X -CSNK1E CK1E P49674 human SRC-3 8202 Q9Y6Q9 NCOA3 human S102 4661900 VQkADVssTGQGVID X X -CSNK1E CK1E P49674 human CK1E 1454 P49674 CSNK1E human S323 453416 RMGQLrGsAtRALPP X -CSNK1E CK1E P49674 human DVL2 1856 O14641 DVL2 human S143 7320089 FHPNVSssHENLEPE Dishevelled X X -CSNK1E CK1E P49674 human TDP-43 23435 Q13148 TARDBP human S410 3084601 ssMDskssGWGM___ X X -CSNK1E CK1E P49674 human LRP6 4040 O75581 LRP6 human S1420 460717 YVVHGPAsVPLGYVP X -CSNK1E CK1E P49674 human SNCA 6622 P37840 SNCA human T64 1876998407 EktkEQVtNVGGAVV Synuclein X -CSNK1E CK1E P49674 human LRP6 4040 O75581 LRP6 human S1431 460718 GYVPHPSsLSGSLPG X -CSNK1E CK1E P49674 human YAP1 10413 P46937 YAP1 human S400 9764918 SRDEstDsGLsMsSy X X -CSNK1E CK1E P49674 human ZBED3 72114 Q9D0L1 Zbed3 mouse S111 6738702 MPCPPPPsPtMAAEG X -CSNK1E CK1E P49674 human CK1E 1454 P49674 CSNK1E human T407 453420 sRIPAsQtsVPFDHL X -CSNK1E CK1E P49674 human CDH1 999 P12830 CDH1 human S844 478354 GsGsEAAsLSsLNsS CADH_Y-type_LIR X -CSNK1E CK1E P49674 human TRAF3 7187 Q13114 TRAF3 human Y446 1869973806 SLYSQPFyTGYFGYK X -CSNK1E CK1E P49674 human TRAF3 7187 Q13114 TRAF3 human S349 8098598 QNWEEADsMkSSVEs X X -CSNK1E CK1E P49674 human RAD17 5884 O75943 RAD17 human T681 1868913302 EDyEsDGt_______ X -CSNK1E CK1E P49674 human DVL2 1856 O14641 DVL2 human T224 25538000 MSRFssStEQSsASR Dishevelled X X -CSNK1E CK1E P49674 human TDP-43 23435 Q13148 TARDBP human S403 3084617 GFNGGFGssMDskss X X -CSNK1E CK1E P49674 human SNCA 20617 O55042 Snca mouse T64 1876998407 EKtKEQVtNVGGAVV Synuclein X -CSNK1E CK1E P49674 human DVL3 1857 Q92997 DVL3 human S633 34668137 GPAASEHsHRsHHsL Dsh_C X -CSNK1E CK1E P49674 human DVL3 1857 Q92997 DVL3 human S639 34668134 HsHRsHHsLAssLRS Dsh_C X -CSNK1E CK1E P49674 human DVL3 1857 Q92997 DVL3 human S612 3830508 sDHttRssLRGPRER Dsh_C X -CSNK1E CK1E P49674 human PER1 18626 O35973 Per1 mouse S714 465536 ALANKAEsVVSVTSQ X X -CSNK1E CK1E P49674 human APC 324 P25054 APC human S1279 450136 sRCSSLssLSSAEDE APC_r X -CSNK1E CK1E P49674 human PER2 8864 O15055 PER2 human S668 20688400 EsVAsLTsQCsYSST X -CSNK1E CK1E P49674 human DVL1 13542 P51141 Dvl1 mouse S139 470073 DNETGTEsMVsHRRE Dishevelled X X -CSNK1E CK1E P49674 human CTNNB1 12387 Q02248 Ctnnb1 mouse S45 447488 GATtTAPsLsGkGNP X X 9565; 9564; 24710; 70034; 19807; 96727; 77605 -CSNK1E CK1E P49674 human TDP-43 23435 Q13148 TARDBP human S404 3084635 FNGGFGssMDskssG X X -CSNK1E CK1E P49674 human DVL3 1857 Q92997 DVL3 human S642 34668133 RsHHsLAssLRSHHT Dsh_C X -CSNK1E CK1E P49674 human CTNNB1 1499 P35222 CTNNB1 human S45 447488 GATtTAPsLsGkGNP X 9565; 9564; 24710; 70034; 19807; 96727; 77605 -CSNK1E CK1E P49674 human p53 22059 P02340 Tp53 mouse S12 447538 EEsQsDIsLELPLsQ P53_TAD X X -CSNK1E CK1E P49674 human CK1E 1454 P49674 CSNK1E human S408 453421 RIPAsQtsVPFDHLG X -CSNK1E CK1E P49674 human TRAF3 7187 Q13114 TRAF3 human Y116 1869973805 EILALQIyCRNESRG X -CSNK1E CK1E P49674 human DVL3 1857 Q92997 DVL3 human S636 34668132 ASEHsHRsHHsLAss Dsh_C X -CSNK1E CK1E P49674 human LRP6 4040 O75581 LRP6 human S1490 456289 AILNPPPsPAtERsH X 2568 -CSNK1E CK1E P49674 human 4E-BP1 1978 Q13541 EIF4EBP1 human T41 449366 ysttPGGtLFsttPG eIF_4EBP X X -CSNK1E CK1E P49674 human TDP-43 23435 Q13148 TARDBP human S409 3084616 GssMDskssGWGM__ X X -CSNK1E CK1E P49674 human PER2 8864 O15055 PER2 human S665 470017 GKAEsVAsLTsQCsY X -CSNK1E CK1E P49674 human ZBED3 72114 Q9D0L1 Zbed3 mouse T113 6738703 CPPPPsPtMAAEGDW X -CSNK1E CK1E P49674 human PER2 8864 O15055 PER2 human S480 50596800 PVPHSGSsGYGSLGS X X -CSNK1E CK1E P49674 human hnRNP P2 2521 P35637 FUS human S182 1878186704 GNYGQDQssMSSGGG X -CSNK1E CK1E P49674 human FMR1 14265 P35922 Fmr1 mouse S499 469583 NSEAsNAsETESDHR FXMRP1_C_core X -CSNK1E CK1E P49674 human CK1E 1454 P49674 CSNK1E human S368 449793 NtsPRAIsRVDRERK X -CSNK1E CK1E P49674 human YAP1 10413 P46937 YAP1 human S403 3190675 EstDsGLsMsSySVP X X -CSNK1E CK1E P49674 human DVL1 13542 P51141 Dvl1 mouse S142 470074 TGTEsMVsHRRERAR Dishevelled X X -CSNK1E CK1E P49674 human APC 324 P25054 APC human S1392 450135 sRCTsVSsLDsFESR APC_r X -CSNK1E CK1E P49674 human PRKD2 25865 Q9BZL6 PRKD2 human S244 1028300 sssSssAssyTGRPI X X -CSNK1E CK1E P49674 human CK1E 1454 P49674 CSNK1E human S405 449794 EVsRIPAsQtsVPFD X -CSNK1E CK1E P49674 human CTNND1 iso3 1500 O60716-3 CTNND1 human S268 450453 PQVRVGGssVDLHRF X -CSNK1E CK1E P49674 human DVL3 1857 Q92997 DVL3 human S611 34668129 EsDHttRssLRGPRE Dsh_C X -CSNK1E CK1E P49674 human DVL3 1857 Q92997 DVL3 human S643 34668102 sHHsLAssLRSHHTH Dsh_C X -CSNK1E CK1E P49674 human CK1E 1454 P49674 CSNK1E human T334 453418 ALPPGPPtGAtANRL X -CSNK1E CK1E P49674 human CTNNB1 12387 Q02248 Ctnnb1 mouse T41 447583 GIHsGATtTAPsLsG X X 9561; 9565; 4270; 13537; 41334; 60180 -CSNK1E CK1E P49674 human p53 22059 P02340 Tp53 mouse S7 448716 _MTAMEEsQsDIsLE X X -CSNK1E CK1E P49674 human 4E-BP1 1978 Q13541 EIF4EBP1 human T50 3195728 FsttPGGtRIIyDRk eIF_4EBP X X -CSNK1E CK1E P49674 human p53 22059 P02340 Tp53 mouse S9 447537 TAMEEsQsDIsLELP P53_TAD X X 9285 -CSNK1E CK1E P49674 human CTNND1 1500 O60716 CTNND1 human S268 450453 PQVRVGGssVDLHRF X -CSNK1E CK1E P49674 human CK1E 1454 P49674 CSNK1E human T337 453419 PGPPtGAtANRLrsA X -CSNK1E CK1E P49674 human DVL3 1857 Q92997 DVL3 human S280 34668101 DGGIYIGsIMkGGAV PDZ X -CSNK1E CK1E P49674 human Snail1 6615 O95863 SNAI1 human S107 455882 sQPPsPPsPAPssFS X -CSNK1E CK1E P49674 human FZD6 8323 O60353 FZD6 human S648 1275585104 sVSESARsEGRIsPK X -CSNK1E CK1E P49674 human CK1E 1454 P49674 CSNK1E human T325 453417 GQLrGsAtRALPPGP X -Prkdc DNAPK P97313 mouse FIS1 66437 Q9CQ92 Fis1 mouse T34 1876807204 AGsVSKStQFEYAWC Fis1_TPR_N X -Prkdc DNAPK P97313 mouse LKB1 20869 Q9WTK7 Stk11 mouse T366 448151 IEDGIIytQDFTVPG X -Prkdc DNAPK P97313 mouse LKB1 20869 Q9WTK7 Stk11 mouse S431 448147 sNKIRRLsACKQQ__ X 3482 -Mapkapk2 MAPKAPK2 P49138 mouse TTP 22695 P22893 Zfp36 mouse T249 3103927 CPSCRRsttPStIWG X -Mapkapk2 MAPKAPK2 P49138 mouse TTP 22695 P22893 Zfp36 mouse S316 451153 LPIFNRIsVsE____ X X -Mapkapk2 MAPKAPK2 P49138 mouse TTP 22695 P22893 Zfp36 mouse S52 451150 RLTGRSTsLVEGRsC X X -Mapkapk2 MAPKAPK2 P49138 mouse TFCP2L1 81879 Q3UNW5 Tfcp2l1 mouse S393 1875342302 LPQKQDDsGDNsLCV X -Mapkapk2 MAPKAPK2 P49138 mouse TTP 22695 P22893 Zfp36 mouse S176 3103925 QPHVLRQsIsFsGLP X -Mapkapk2 MAPKAPK2 P49138 mouse TTP 22695 P22893 Zfp36 mouse S264 2897405 PLGGLARsPsAHsLG X -Mapkapk2 MAPKAPK2 P49138 mouse RIPK1 19766 Q60855 Ripk1 mouse S336 209632700 LPPsRsNsEQPGSLH X X -Mapkapk2 MAPKAPK2 P49138 mouse MDM2 4193 Q00987 MDM2 human S166 448130 SsRRRAIsEtEENsD X 3521 -Mapkapk2 MAPKAPK2 P49138 mouse TTP 22695 P22893 Zfp36 mouse S178 451151 HVLRQsIsFsGLPsG X X -Mapkapk2 MAPKAPK2 P49138 mouse TTP 22695 P22893 Zfp36 mouse S58 457791 TsLVEGRsCGWVPPP X -Mapkapk2 MAPKAPK2 P49138 mouse HSP27 15507 P14602 Hspb1 mouse S15 448401 FsLLrsPsWEPFRDW X -Mapkapk2 MAPKAPK2 P49138 mouse HSPA1L 3305 P34931 HSPA1L human S241 1869383201 DFDNRLVsHFVEEFK HSP70 X -Mapkapk2 MAPKAPK2 P49138 mouse hnRNP A0 77134 Q9CX86 Hnrnpa0 mouse S84 449874 VELKRAVsREDsARP X X -Mapkapk2 MAPKAPK2 P49138 mouse TFCP2L1 81879 Q3UNW5 Tfcp2l1 mouse S397 1875342304 QDDsGDNsLCVyHAI X -Mapkapk2 MAPKAPK2 P49138 mouse TTP 22695 P22893 Zfp36 mouse S266 3103920 GGLARsPsAHsLGsD X -Mapkapk2 MAPKAPK2 P49138 mouse TTP 22695 P22893 Zfp36 mouse S85 2295101 ELsPsPtsPtATPTT X -Mapkapk2 MAPKAPK2 P49138 mouse C/EBP-beta 12608 P28033 Cebpb mouse T188 447878 sSssPPGtPSPADAK X X 3084 -Mapkapk2 MAPKAPK2 P49138 mouse TTP 22695 P22893 Zfp36 mouse T84 457793 PELsPsPtsPtATPT X -Mapkapk2 MAPKAPK2 P49138 mouse TTP 22695 P22893 Zfp36 mouse S105 3103926 TELCRTYsESGRCRY zf-CCCH X -Mapkapk2 MAPKAPK2 P49138 mouse TTP 22695 P22893 Zfp36 mouse T250 451152 PSCRRsttPStIWGP X X -Mapkapk2 MAPKAPK2 P49138 mouse UBE2J1 56228 Q9JJZ4 Ube2j1 mouse S184 465537 KELARQIsFKAEVNS X X -Mapkapk2 MAPKAPK2 P49138 mouse RIPK1 19766 Q60855 Ripk1 mouse S321 468644 PVLQRMFsLQHDCVP X X 83613; 38662 -CAMK1 CAMK1A Q14012 human p27Kip1 12576 P46414 Cdkn1b mouse T170 6058800 QNkRANRtEENVsDG X -CAMK1 CAMK1A Q14012 human QIK 315649 Q3LRT3 Sik2 rat T484 478056 RSGQRRHtLSEVTNQ X X -CAMK1 CAMK1A Q14012 human TH 25085 P04177 Th rat S19 448542 KGFRRAVsEQDAKQA TOH_N X -CAMK1 CAMK1A Q14012 human MARK2 60328 O08679 Mark2 rat T294 26573805 LNPSKRGtLEQIMKD Pkinase X -CAMK1 CAMK1A Q14012 human PKLR 24651 P12928 Pklr rat T53 451507 QLtQELGtAFFQQQQ X -CAMK1 CAMK1A Q14012 human PKLR iso2 24651 P12928-2 Pklr rat T17 451506 RAsVAQLtQELGtAF X -CAMK1 CAMK1A Q14012 human RPS19 P17074 Rps19 rat S59 7113803 WFYTRAAsTARHLYL Ribosomal_S19e X -CAMK1 CAMK1A Q14012 human HDAC5 10014 Q9UQL6 HDAC5 human S498 447996 RPLSRtQsSPLPQsP X 3424 -CAMK1 CAMK1A Q14012 human ARHGEF7 114559 O55043 Arhgef7 rat S516 455215 RKPERKPsDEEFAVR RhoGEF67_u2 X X -CAMK1 CAMK1A Q14012 human HDAC7 56233 Q8C2B3 Hdac7 mouse S479 452459 RPLsRtQssPAAPVS X 3424 -CAMK1 CAMK1A Q14012 human GCM1 8521 Q9NP62 GCM1 human T174 20745203 RAMKKVNtAPssVSL X -CAMK1 CAMK1A Q14012 human HDAC7 56233 Q8C2B3 Hdac7 mouse S344 455621 RPLNRtRsEPLPPsA X -CAMK1 CAMK1A Q14012 human RYR1 100009540 P11716 RYR1 rabbit S2843 451818 KKKTRKIsQTAQTYD X -CAMK1 CAMK1A Q14012 human PKLR iso2 24651 P12928-2 Pklr rat T22 451507 QLtQELGtAFFQQQQ X -CAMK1 CAMK1A Q14012 human p27Kip1 1027 P46527 CDKN1B human T157 448645 GIRkrPAtDDSSTQN X X -CAMK1 CAMK1A Q14012 human p27Kip1 1027 P46527 CDKN1B human T198 448781 PGLRRRQt_______ X X -CAMK1 CAMK1A Q14012 human GCM1 8521 Q9NP62 GCM1 human S177 20745202 KKVNtAPssVSLSLK X -CAMK1 CAMK1A Q14012 human NUMB 29419 Q2LC84 Numb rat S294 470030 SPFKRQLsLRINELP NumbF X -CAMK1 CAMK1A Q14012 human PKLR 24651 P12928 Pklr rat T48 451506 RASVAQLtQELGtAF X -CAMK1 CAMK1A Q14012 human MARK2 60328 O08679 Mark2 rat S92 26573804 DKTQLNssSLQKLFR Pkinase X -CAMK1 CAMK1A Q14012 human GCM1 8521 Q9NP62 GCM1 human S47 20745200 YAKHIYSsEDKNAQR GCM X X -CAMK1 CAMK1A Q14012 human EIF4G3 8672 O43432 EIF4G3 human S1156 2915400 NTFMRGGssKDLLDN X -CAMK1 CAMK1A Q14012 human SIK 59329 Q9R1U5 Sik1 rat T322 990311 LGIDRQRtVESLQNS X -CAMK1 CAMK1A Q14012 human TH 25085 P04177 Th rat S40 448545 RFIGRRQsLIEDARK TOH_N X 2791 -CAMK1 CAMK1A Q14012 human NUMB 29419 Q2LC84 Numb rat S275 456490 EQLARQGsFRGFPAL NumbF X 4140; 9878 -CAMK1 CAMK1A Q14012 human MRLC1 10398 P24844 MYL9 human S20 1863500 KRPQRAtsNVFAMFD X 3674; 3671; 3675; 95777 -CAMK1 CAMK1A Q14012 human GCM1 8521 Q9NP62 GCM1 human S178 20745201 KVNtAPssVSLSLKG X -CAMK1 CAMK1A Q14012 human GCM1 8521 Q9NP62 GCM1 human S269 18788303 LYEKRKLsSSRTYsS X -CAMK1 CAMK1A Q14012 human HSL 3991 Q05469 LIPE human S855 448804 EPMRRsVsEAALAQP X 4137 -CAMK1 CAMK1A Q14012 human CAMK2A iso2 815 Q9UQM7-2 CAMK2A human S332 3143902 DGVKkRKssssVQLM X -CAMK1 CAMK1A Q14012 human PPME1 51400 Q9Y570 PPME1 human S15 476688 MHLGRLPsrPPLPGs X X -CAMK1 CAMK1A Q14012 human HDAC5 10014 Q9UQL6 HDAC5 human S259 447995 FPLRkTAsEPNLKVR X 3443 -CAMK1 CAMK1A Q14012 human DRP1 114114 O35303 Dnm1l rat S656 483971 VPVARKLsAREQRDC X X 4867; 6319 -CAMK1 CAMK1A Q14012 human MARK2 60328 O08679 Mark2 rat S91 26573803 IDKTQLNssSLQKLF Pkinase X -CAMK1 CAMK1A Q14012 human RPS19 6223 P39019 RPS19 human S59 7113803 WFytrAAsTARHLYL Ribosomal_S19e X -CAMK1 CAMK1A Q14012 human p27Kip1 12576 P46414 Cdkn1b mouse T197 448781 KPGLRRQt_______ X -CAMK1 CAMK1A Q14012 human RPS19 20085 Q9CZX8 Rps19 mouse S59 7113803 WFYTRAAsTARHLYL Ribosomal_S19e X -CAMK1 CAMK1A Q14012 human HDAC7 56233 Q8C2B3 Hdac7 mouse S178 455620 FPLRKTVsEPNLKLR X 3443 -CAMK1 CAMK1A Q14012 human HDAC9 9734 Q9UKV0 HDAC9 human S220 448485 FPLRkTAsEPNLKVR X -CAMK1 CAMK1A Q14012 human HDAC9 9734 Q9UKV0 HDAC9 human S451 448486 RPLNRtQsAPLPQST X -Rps6kb1 p70S6K Q8BSK8 mouse IRS1 3667 P35568 IRS1 human S636 447506 sGDyMPMsPKsVSAP X 2388 -Rps6kb1 p70S6K Q8BSK8 mouse ER-alpha 13982 P19785 Esr1 mouse S171 448102 NGRERLSsSNEKGNM Oest_recep X -Rps6kb1 p70S6K Q8BSK8 mouse CREM 12916 P27699 Crem mouse S133 448412 EILSRRPsYRKILNE pKID X X 4095; 14228; 14001 -Rps6kb1 p70S6K Q8BSK8 mouse IRS1 3667 P35568 IRS1 human S307 450190 TRRsRtEsItAtsPA X 2384; 2491 -Rps6kb1 p70S6K Q8BSK8 mouse GluR1 14799 P23818 Gria1 mouse T858 3362100 NEAIRtstLPRNsGA X -Rps6kb1 p70S6K Q8BSK8 mouse IRS1 3667 P35568 IRS1 human S639 447507 yMPMsPKsVSAPQQI X 2388 -Rps6kb1 p70S6K Q8BSK8 mouse S6 20104 P62754 Rps6 mouse S235 448092 IAKRRRLssLRAsts X X 5006; 4856; 4857; 4858; 4851; 4803; 2211; 3945; 3985; 5316; 4854; 8520; 48319; 40643; 9865; 38573; 14733; 27036; 34411; 62016; 62788; 81736; 97935; 99457; 15448 -Rps6kb1 p70S6K Q8BSK8 mouse MDM2 17246 P23804 Mdm2 mouse S163 448130 SSRRRsIsEtEENTD X 3521 -Rps6kb1 p70S6K Q8BSK8 mouse FMR1 14265 P35922 Fmr1 mouse S499 469583 NSEAsNAsETESDHR FXMRP1_C_core X X -Rps6kb1 p70S6K Q8BSK8 mouse IRS1 3667 P35568 IRS1 human S312 447558 tEsItAtsPAsMVGG X 2381 -Rps6kb1 p70S6K Q8BSK8 mouse GSK3B 56637 Q9WV60 Gsk3b mouse S9 449111 SGRPRttsFAEsCKP X 9336; 9331; 9327; 9323; 9322; 9325; 5558; 8566; 79774; 8466; 25462; 14026; 14332; 14310; 14630 -Rps6kb1 p70S6K Q8BSK8 mouse CCT2 12461 P80314 Cct2 mouse S260 472352 GsRVRVDsTAKVAEI Cpn60_TCP1 X X -Rps6kb1 p70S6K Q8BSK8 mouse LKB1 20869 Q9WTK7 Stk11 mouse S431 448147 sNKIRRLsACKQQ__ X 3482 -Rps6kb1 p70S6K Q8BSK8 mouse IRS1 25467 P35570 Irs1 rat S1100 453434 GCRRRHssEtFSAPt X 2385 -Rps6kb1 p70S6K Q8BSK8 mouse p14ARF 12578 Q64364 Cdkn2a mouse S71 50440900 GDDDGQRsRSSSSAQ X X -Rps6kb1 p70S6K Q8BSK8 mouse DNAJC2 22791 P54103 Dnajc2 mouse S47 469782 KRRNRNAstsFQELE X 12397 -Rps6kb1 p70S6K Q8BSK8 mouse S6 20104 P62754 Rps6 mouse S236 448093 AKRRRLssLRAstsK X X 5006; 4856; 4857; 4858; 4851; 4803; 2211; 3945; 3985; 5316; 4854; 8520; 48319; 40643; 9865; 38573; 14733; 27036; 34411; 62016; 62788; 81736; 97935; 99457; 15448 -Rps6kb1 p70S6K Q8BSK8 mouse IRS1 3667 P35568 IRS1 human S616 447562 DDGyMPMsPGVAPVP X 3193; 2386; 3203 -TNNI3K TNNI3K Q59H18 human TNNI3 29248 P23693 Tnni3 rat S43 450690 AKKKSKIsAsRKLQL X -TNNI3K TNNI3K Q59H18 human TNNI3 29248 P23693 Tnni3 rat T144 451483 RGKFkRPtLRRVRIs Troponin X -CKM CKM P00565 chicken CKM 396507 P00565 CKM chicken S285 451823 GYILtCPsNLGtGLR ATP-gua_Ptrans X -CKM CKM P00565 chicken CKM 396507 P00565 CKM chicken T282 451820 EHLGYILtCPsNLGt ATP-gua_Ptrans X -CKM CKM P00565 chicken CKM 396507 P00565 CKM chicken T289 451821 tCPsNLGtGLRGGVH ATP-gua_Ptrans X -BCR/ABL BCR-ABL1 A9UF07 human SMAD4 4089 Q13485 SMAD4 human Y301 1881244702 MPPHPGHyWPVHNEL X -BCR/ABL BCR-ABL1 A9UF07 human RAD51 5888 Q06609 RAD51 human Y315 448324 EtRICKIyDSPCLPE Rad51 X -BCR/ABL BCR-ABL1 A9UF07 human Bcr 613 P11274 BCR human Y177 447792 ADAEKPFyVNVEFHH X 3901 -BCR/ABL BCR-ABL1 A9UF07 human Bcr 613 P11274 BCR human Y360 447796 VsPsPttyRMFRDKS X X -BCR/ABL BCR-ABL1 A9UF07 human JAK2 16452 Q62120 Jak2 mouse Y1008 448408 LPQDKEyyKVKEPGE PK_Tyr_Ser-Thr X 3771; 3776; 8082; 66245; 32901 -BCR/ABL BCR-ABL1 A9UF07 human GRB2 2885 P62993 GRB2 human Y209 448512 TGMFPRNyVtPVNrN X -BCR/ABL BCR-ABL1 A9UF07 human Abl 25 P00519 ABL1 human Y257 450300 GGQyGEVyEGVWKKy PK_Tyr_Ser-Thr X -BCR/ABL BCR-ABL1 A9UF07 human RAD52 5893 P43351 RAD52 human Y104 449061 DLNNGKFyVGVCAFV Rad52_Rad22 X -BCR/ABL BCR-ABL1 A9UF07 human SMAD4 4089 Q13485 SMAD4 human Y195 1881244700 NRASTETyStPALLA X -BCR/ABL BCR-ABL1 A9UF07 human CRKL 1399 P46109 CRKL human Y207 447954 IPEPAHAyAQPQttt X X 3181; 34940; 94358 -BCR/ABL BCR-ABL1 A9UF07 human Bcr 613 P11274 BCR human Y328 447795 FEDCGGGytPDCSSN X -BCR/ABL BCR-ABL1 A9UF07 human Abl 25 P00519 ABL1 human Y253 450301 HKLGGGQyGEVyEGV PK_Tyr_Ser-Thr X -BCR/ABL BCR-ABL1 A9UF07 human CDV-3 321022 Q4VAA2 Cdv3 mouse Y120 450290 FEQREVDySGLRVQA CDV3 X -BCR/ABL BCR-ABL1 A9UF07 human RHOA 387 P61586 RHOA human Y66 475231 DtAGQEDyDRLRPLS Ras X -BCR/ABL BCR-ABL1 A9UF07 human JAK2 16452 Q62120 Jak2 mouse Y1007 448407 VLPQDKEyyKVKEPG PK_Tyr_Ser-Thr X X 3771; 3776; 4406; 66245; 32901 -BCR/ABL BCR-ABL1 A9UF07 human CHCHD2 51142 Q9Y6H1 CHCHD2 human Y99 62463400 PARPDITyQEPQGTQ X -BCR/ABL BCR-ABL1 A9UF07 human Lasp-1 3927 Q14847 LASP1 human Y171 451675 IPtsAPVyQQPQQQP X -BCR/ABL BCR-ABL1 A9UF07 human Bcr 613 P11274 BCR human Y283 447794 yQPyQsIyVGGMMEG X -BCR/ABL BCR-ABL1 A9UF07 human RHOA 387 P61586 RHOA human Y34 473955 kDQFPEVyVPTVFEN Ras X -BCR/ABL BCR-ABL1 A9UF07 human Abl 25 P00519 ABL1 human Y232 450302 VyGVsPNyDKWEMER X -BCR/ABL BCR-ABL1 A9UF07 human SMAD4 4089 Q13485 SMAD4 human Y322 1881244704 SNHPAPEyWCSIAYF X -YES1 Yes P07947 human YAP1 10413 P46937 YAP1 human Y407 473004 sGLsMsSySVPRtPD X X -YES1 Yes P07947 human CDC37 11140 Q16543 CDC37 human Y4 34490407 ____MVDysVWDHIE CDC37_N X X -YES1 Yes P07947 human NRF2 4780 Q16236 NFE2L2 human Y576 460703 RDEDGkPysPSEYSL X -YES1 Yes P07947 human FAK 5747 Q05397 PTK2 human Y925 447966 DRsNDkVyENVtGLV Focal_AT X 3284 -YES1 Yes P07947 human ANXA2 302 P07355 ANXA2 human Y24 449483 HstPPsAyGsVkAyt X X -YES1 Yes P07947 human NPHS1 4868 O60500 NPHS1 human Y1193 469565 SGAWGPLyDEVQMGP X -YES1 Yes P07947 human YAP1 10413 P46937 YAP1 human Y391 15565111 PFLNsGtyHSRDEst X X -YES1 Yes P07947 human HER2 2064 P04626 ERBB2 human Y877 448694 LDIDEtEyHADGGkV PK_Tyr_Ser-Thr X 2241 -YES1 Yes P07947 human DLC1 50768 Q9R0Z9 Dlc1 mouse Y702 1869008601 SAEDNVNyEGQSAYD RhoGAP X -YES1 Yes P07947 human TAZ 25937 Q9GZV5 WWTR1 human Y305 1876136800 PFLNGGPyHsREQst X X -YES1 Yes P07947 human FAK 5747 Q05397 PTK2 human Y861 447965 PIGNQHIyQPVGKPD X -YES1 Yes P07947 human WBP2 23558 Q969T9 WBP2 human Y231 464521 AEAAASAyyNPGNPH X -YES1 Yes P07947 human DLC1 50768 Q9R0Z9 Dlc1 mouse Y452 1869008602 NVPGSILySSSGELA X -YES1 Yes P07947 human p27Kip1 1027 P46527 CDKN1B human Y89 456819 GsLPEFyyRPPRPPK X -YES1 Yes P07947 human CRMP-2 1808 Q16555 DPYSL2 human Y479 18833900 kPFPDFVyKRIKARS X -YES1 Yes P07947 human WBP2 23558 Q969T9 WBP2 human Y192 20612405 MMDGAMGyVQPPPPP X -YES1 Yes P07947 human Ets-1 2113 P14921 ETS1 human Y283 449428 sLQRVPsyDsFDsED Ets1_N_flank X -YES1 Yes P07947 human 5-LO 240 P09917 ALOX5 human Y54 33670310 ERGAVDSyDVTVDEE PLAT X -YES1 Yes P07947 human p27Kip1 1027 P46527 CDKN1B human Y88 456818 kGsLPEFyyRPPRPP X -YES1 Yes P07947 human 5-LO 240 P09917 ALOX5 human Y446 33670311 RAMKDLtyAsLCFPE Lipoxygenase X -YES1 Yes P07947 human p27Kip1 1027 P46527 CDKN1B human Y74 475060 HkPLEGkyEWQEVEk CDI X -YES1 Yes P07947 human CDC37 11140 Q16543 CDC37 human Y298 451691 GLDPVEVyEsLPEEL CDC37_C X X -YES1 Yes P07947 human CDK4 1019 P11802 CDK4 human Y17 455500 AEIGVGAyGTVYkAR Pkinase X X -YES1 Yes P07947 human 5-LO 240 P09917 ALOX5 human Y43 33670312 HLLDKPFyNDFERGA PLAT X -YES1 Yes P07947 human SOCS1 8651 O15524 SOCS1 human Y80 1868450203 LLDACGFyWGPLSVH SH2 X -YES1 Yes P07947 human GLO1 2739 Q04760 GLO1 human Y136 463450 GIAVPDVysACkRFE Glyoxalase X X -Akt1 Akt1 P31750 mouse BIM 10018 O43521 BCL2L11 human S87 458219 FIFMRRSsLLSRSss X -Akt1 Akt1 P31750 mouse BAD 12015 Q61337 Bad mouse S155 447863 GRELRRMsDEFEGsF Bcl-2_BAD X X 9297 -Akt1 Akt1 P31750 mouse PAK1 18479 O88643 Pak1 mouse S21 448174 APPMRNTsTMIGAGS X -Akt1 Akt1 P31750 mouse ERR3 26381 P62509 Esrrg mouse S179 36400701 ITKRRRKsCQACRFM zf-C4 X -Akt1 Akt1 P31750 mouse BACH2 12014 P97303 Bach2 mouse S520 470117 EtRTRtsssCssYsY X -Akt1 Akt1 P31750 mouse QIK 235344 Q8CFH6 Sik2 mouse S358 487501 DGRQRRPstIAEQTV X -Akt1 Akt1 P31750 mouse AMPKA1 105787 Q5EG47 Prkaa1 mouse S496 450431 AtPQRsGsIsNYRsC AdenylateSensor X 4185; 4184; 2537 -Akt1 Akt1 P31750 mouse DLK 26404 Q60700 Map3k12 mouse S584 40416401 KTRHRKAsAKGsCGD X -Akt1 Akt1 P31750 mouse CSK 12988 P41241 Csk mouse S284 23096469 YLRSRGRsVLGGDCL PK_Tyr_Ser-Thr X -Akt1 Akt1 P31750 mouse CDC25B 12531 P30306 Cdc25b mouse S351 452008 VQSKRRKsVtPLEEQ M-inducer_phosp X -Akt1 Akt1 P31750 mouse NDRG2 29811 Q9QYG0 Ndrg2 mouse T348 451009 GsRsRsRtLsQssEs X -Akt1 Akt1 P31750 mouse PRAS40 84335 Q96B36 AKT1S1 human T246 470067 LPRPRLNtsDFQkLK PRAS X 2640; 2997; 32263; 13175; 60202 -Akt1 Akt1 P31750 mouse FOXO1A 56458 Q9R1E0 Foxo1 mouse S253 448075 sPRRRAAsMDNNSkF X X 9461; 84192 -Akt1 Akt1 P31750 mouse SHP-1 15170 P29351 Ptpn6 mouse T394 23144271 TAEYkLRtLQISPLD Y_phosphatase X -Akt1 Akt1 P31750 mouse AS160 210789 Q8BYJ6 Tbc1d4 mouse T649 455921 QFRRRAHtFsHPPSS X X 4288; 8881 -Akt1 Akt1 P31750 mouse PDE3B 18576 Q61409 Pde3b mouse S273 447699 VIRPRRRssCVsLGE X X -Akt1 Akt1 P31750 mouse ULK1 22241 O70405 Ulk1 mouse S774 4699305 STRTRMFsVGsSSsL X -Akt1 Akt1 P31750 mouse DLK 26404 Q60700 Map3k12 mouse T659 40416400 GARGRGAtGGARDPG X -Akt1 Akt1 P31750 mouse HCN2 15166 O88703 Hcn2 mouse S861 1871246002 SARSRLSsNL_____ X -Akt1 Akt1 P31750 mouse ACLY 104112 Q91V92 Acly mouse S455 448631 PAPsRtAsFsEsRAD X 4331 -Akt1 Akt1 P31750 mouse PIKFYVE 18711 Q9Z1T6 Pikfyve mouse S307 457532 PARNRsAsItNLsLD X -Akt1 Akt1 P31750 mouse TSC2 22084 Q61037 Tsc2 mouse S939 448501 SFRARSTsLNERPKs X 3615 -Akt1 Akt1 P31750 mouse FOXO1A 56458 Q9R1E0 Foxo1 mouse S316 449113 TFRPRTSsNAstISG X 2486 -Akt1 Akt1 P31750 mouse PIKFYVE 18711 Q9Z1T6 Pikfyve mouse S48 3887627 PFKSAYSsFVNLFRF X -Akt1 Akt1 P31750 mouse RAF1 110157 Q99N57 Raf1 mouse S259 447741 SQRQRStsTPNVHMV X 9421; 20011 -Akt1 Akt1 P31750 mouse PANX3 208098 Q8CEG0 Panx3 mouse S68 1869686803 GSPISCFsPSNFSVR Innexin X -Akt1 Akt1 P31750 mouse H3 iso3 15081 P84244 H3f3b mouse S10 455676 tKQTARksTGGkAPR Histone X 9701; 9711; 9706; 3465; 3642; 3377; 3475; 3458; 5764; 47398; 8481; 8552; 53348; 29237; 66065; 43185; 64522; 52725 -Akt1 Akt1 P31750 mouse MKK4 26398 P47809 Map2k4 mouse S78 447655 IERLRTHsIESsGKL X 9155 -Akt1 Akt1 P31750 mouse GRB10 14783 Q60760 Grb10 mouse S455 455333 NAPMRsVsENsLVAM BPS X -Akt1 Akt1 P31750 mouse CTNNB1 12387 Q02248 Ctnnb1 mouse S552 472273 QDTQRRtsMGGtQQQ X 9566; 5651 -Akt1 Akt1 P31750 mouse Bcl-3 602 P20749 BCL3 human S41 27444668 kRPLRAPsPEPAAPR X -Akt1 Akt1 P31750 mouse GSK3A 606496 Q2NL51 Gsk3a mouse S21 448584 sGRARtssFAEPGGG X 9337; 9316; 9331; 9327; 8452; 8566 -Akt1 Akt1 P31750 mouse E2A iso2 21423 P15806-2 Tcf3 mouse S527 483180 VPRtRtsstDEVLsL X -Akt1 Akt1 P31750 mouse BAD 12015 Q61337 Bad mouse S112 447860 ETRsRHssyPAGtEE Bcl-2_BAD X X 9291; 5284; 9296; 5193; 11865; 94223 -Akt1 Akt1 P31750 mouse AS160 210789 Q8BYJ6 Tbc1d4 mouse S595 455920 RMRGRLGsMDsFERA X 8730 -Akt1 Akt1 P31750 mouse Akt1 11651 P31750 Akt1 mouse S473 447855 RPHFPQFsysAsGtA Pkinase_C X X 9271; 3787; 4060; 4051; 5102; 4058; 2336; 2337; 4075; 4070; 5012; 4071; 92982; 5315; 9563; 9018; 12694; 52240; 11962; 15116; 88106; 26580; 68035; 31957; 23430; 20235 -Akt1 Akt1 P31750 mouse MDM2 17246 P23804 Mdm2 mouse S163 448130 SSRRRsIsEtEENTD X 3521 -Akt1 Akt1 P31750 mouse GSK3B 56637 Q9WV60 Gsk3b mouse S9 449111 SGRPRttsFAEsCKP X X 9336; 9331; 9327; 9323; 9322; 9325; 5558; 8566; 79774; 8466; 25462; 14026; 14332; 14310; 14630 -Akt1 Akt1 P31750 mouse FOXO3A 56484 Q9WVH4 Foxo3 mouse T32 448602 QSRPRSCtWPLQRPE X 9464 -Akt1 Akt1 P31750 mouse lamin A/C 60374 P48679 Lmna rat S404 478681 RSRGRAssHssQSQG X -Akt1 Akt1 P31750 mouse PERK 13666 Q9Z2B5 Eif2ak3 mouse T799 11073906 YTRSREGtSSSIVFE X -Akt1 Akt1 P31750 mouse FOXO1A 56458 Q9R1E0 Foxo1 mouse T24 448560 LPRQRSCtWPLPRPE X X 2599; 9464 -Akt1 Akt1 P31750 mouse TBC1D1 57915 Q60949 Tbc1d1 mouse T590 1247778 AFRRRANtLsHFPVE X -Akt1 Akt1 P31750 mouse IRS2 29376 F1MAL5 Irs2 rat S574 483923 GLRKRTYsLTTPARQ X -Akt1 Akt1 P31750 mouse BAD 12015 Q61337 Bad mouse S136 447862 PFRGRsRsAPPNLWA Bcl-2_BAD X X 9295; 5286; 4366 -Akt1 Akt1 P31750 mouse LGMN 19141 O89017 Lgmn mouse T324 23121345 LKRKLLRtNDVKESQ X -Akt1 Akt1 P31750 mouse FOXO3A 2309 O43524 FOXO3 human S253 449108 APRRRAVsMDNSNkY X 9466; 13129 -Akt1 Akt1 P31750 mouse AS160 210789 Q8BYJ6 Tbc1d4 mouse S324 455925 EFRsRCssVTGVMQK PID X 8619 -Akt1 Akt1 P31750 mouse PHB 18673 P67778 Phb1 mouse T258 11139253 LSRSRNItyLPAGQs X -Akt1 Akt1 P31750 mouse CS 12974 Q9CZU6 Cs mouse S225 4774521 RNLYREGssIGAIDs Citrate_synt X -Akt1 Akt1 P31750 mouse STX7 53331 O70439 Stx7 mouse S126 468881 VARVRAssRVsGGFP X -Akt1 Akt1 P31750 mouse Nur77 3164 P22736 NR4A1 human S351 447942 GRRGRLPsKPKQPPD X 5095 -Akt1 Akt1 P31750 mouse TFEB 21425 Q9R210 Tfeb mouse S466 4785142 KAssRRssFsMEEGD DUF3371 X -Akt1 Akt1 P31750 mouse PAK6 56924 Q9NQU5 PAK6 human S113 5208141 TSRRRAQsLGLLGDE X -Akt1 Akt1 P31750 mouse GATA1 14460 P17679 Gata1 mouse S310 451231 QTRNRkAsGkGKKkR X -Akt1 Akt1 P31750 mouse S6 20104 P62754 Rps6 mouse S236 448093 AKRRRLssLRAstsK X 5006; 4856; 4857; 4858; 4851; 4803; 2211; 3945; 3985; 5316; 4854; 8520; 48319; 40643; 9865; 38573; 14733; 27036; 34411; 62016; 62788; 81736; 97935; 99457; 15448 -Akt1 Akt1 P31750 mouse GLI2 14633 Q0VGT2 Gli2 mouse S230 2677401 LSrKrALsIsPLSDA X X -Akt1 Akt1 P31750 mouse girdin 108686 Q5SNZ0 Ccdc88a mouse S1417 456477 INRERQKsLtLtPTR X X -Prkcb PKCB iso2 P68404-2 mouse TNNI3 21954 P48787 Tnni3 mouse S45 450691 KKSKIsAsRKLQLkT X -Prkcb PKCB iso2 P68404-2 mouse TNNI3 21954 P48787 Tnni3 mouse S23 448423 PAPVRRRssANyRAY Troponin-I_N X -Prkcb PKCB iso2 P68404-2 mouse IRS2 384783 P81122 Irs2 mouse S303 3217341 EFRPRsKsQssGSSA X X -Prkcb PKCB iso2 P68404-2 mouse TNNI3 21954 P48787 Tnni3 mouse T144 451483 RGKFKRPtLRRVRIs Troponin X -Prkcb PKCB iso2 P68404-2 mouse IRS2 384783 P81122 Irs2 mouse S675 472256 sDDyMPMsPtSVSAP X X -Prkcb PKCB iso2 P68404-2 mouse PKCB iso2 18751 P68404-2 Prkcb mouse S660 1869073011 QsEFEGFsFVNsEFL Pkinase_C X -Prkcb PKCB iso2 P68404-2 mouse TNNI3 21954 P48787 Tnni3 mouse S43 450690 AkKKSKIsAsRKLQL X -Prkcb PKCB iso2 P68404-2 mouse TNNI3 21954 P48787 Tnni3 mouse S24 448424 APVRRRssANyRAYA Troponin-I_N X -Src Src P05480 mouse PRDX1 18477 P35700 Prdx1 mouse Y194 448924 DVnkSkEyFsKQK__ 1-cysPrx_C X -Src Src P05480 mouse RPT2 19179 P62192 Psmc1 mouse Y439 451910 EGtPEGLyL______ X -Src Src P05480 mouse Ack 10188 Q07912 TNK2 human Y860 448884 KVsstHyyLLPERPs X -Src Src P05480 mouse Ack 10188 Q07912 TNK2 human Y859 448883 KKVsstHyyLLPERP X -Src Src P05480 mouse CDH5 12562 P55284 Cdh5 mouse Y685 455658 MDARPAVyTQVQkPP X -Ephb2 EphB2 P54763 mouse EphB2 13844 P54763 Ephb2 mouse Y602 448327 IyIDPFtyEDPNEAV EphA2_TM X -Ephb2 EphB2 P54763 mouse EphB2 13844 P54763 Ephb2 mouse Y596 448326 MTPGMKIyIDPFtyE EphA2_TM X -PIK3CG PIK3CG P48736 human SET iso2 6418 Q01105-2 SET human S93 19009801 FVNHPQVsALLGEED NAP X X -PIK3CG PIK3CG P48736 human Src 6714 P12931 SRC human S39 23148310 FPAsQtPsKPAsAdG X -PIK3CG PIK3CG P48736 human SET iso2 6418 Q01105-2 SET human S9 6308300 sAPAAkVsKkELNsN X X -PIK3CG PIK3CG P48736 human Src 6714 P12931 SRC human S70 2192576 LFGGFNssDtVtsPQ X -PIK3CG PIK3CG P48736 human PIK3CG 5294 P48736 PIK3CG human S1101 449882 IKQGEKHsA______ X -TBK1 TBK1 Q9UHD2 human DRP1 74006 Q8K1M6 Dnm1l mouse S643 483971 VPVARKLsAREQRDC X 4867; 6319 -TBK1 TBK1 Q9UHD2 human STING 72512 Q3TBT3 Sting1 mouse S365 31064700 QEPRLLIsGMDQPLP X 62912; 72971; 51865 -TBK1 TBK1 Q9UHD2 human Nik 53859 Q9WUL6 Map3k14 mouse S349 27259008 ALQGSVSsGQAHsLA X -TBK1 TBK1 Q9UHD2 human Raptor 74370 Q8K4Q0 Rptor mouse S1189 23137513 VAGLGDGsIRVYDRR WD40 X -TBK1 TBK1 Q9UHD2 human PELI1 57162 Q96FA3 PELI1 human T80 7388010 DQHsIsYtLsRAQtV Pellino X -TBK1 TBK1 Q9UHD2 human SQSTM1 8878 Q13501 SQSTM1 human S403 22264800 ESLSQMLsMGFsDEG UBA_5 X X 39786 -TBK1 TBK1 Q9UHD2 human PRPS1 5631 P60891 PRPS1 human T228 34551795 DMADtCGtICHAADk Pribosyl_synth X X -TBK1 TBK1 Q9UHD2 human LMO7 iso3 4008 Q8WWI1-3 LMO7 human S417 4687531 KWKDRRKsYTSDLQK DUF4757 X -TBK1 TBK1 Q9UHD2 human optineurin 10133 Q96CV9 OPTN human S177 4762451 ssGssEDsFVEIRMA X X 31304; 57548 -TBK1 TBK1 Q9UHD2 human GABARAPL2 11345 P60520 GABARAPL2 human S88 1869546302 DKTVPQssLTMGQLY ATG8 X X -TBK1 TBK1 Q9UHD2 human DDAH2 23564 O95865 DDAH2 human S253 1872776108 QEALQKLsDVTLVPV X -TBK1 TBK1 Q9UHD2 human TNIP1 10318 Q15025 TNIP1 human S123 1880462802 PPSSGTssEFEVVTP X X -TBK1 TBK1 Q9UHD2 human TRIP12 9320 Q14669 TRIP12 human S312 452826 STKkRsEsPPAELPs X -TBK1 TBK1 Q9UHD2 human p70S6K 6198 P23443 RPS6KB1 human S447 448357 GsPRtPVsPVkFsPG X 9204 -TBK1 TBK1 Q9UHD2 human ASB8 140461 Q9H765 ASB8 human S17 1869062300 QSIQSKYsLSERLIR X -TBK1 TBK1 Q9UHD2 human optineurin 10133 Q96CV9 OPTN human S473 9511914 AQMEVYCsDFHAERA CC2-LZ X X -TBK1 TBK1 Q9UHD2 human SMCR8 140775 Q8TEV9 SMCR8 human T796 55469600 AsPAGAGtLHALSRY X -TBK1 TBK1 Q9UHD2 human GABARAPL2 11345 P60520 GABARAPL2 human S87 1869546303 VDKTVPQssLTMGQL ATG8 X X -TBK1 TBK1 Q9UHD2 human Nik 53859 Q9WUL6 Map3k14 mouse S354 23254681 VSsGQAHsLAsLAKT X -TBK1 TBK1 Q9UHD2 human STING 340061 Q86WV6 STING1 human S366 31064700 QEPELLIsGMEkPLP X X 30495; 39887; 85735; 50907; 19781; 41622; 43499; 40818; 99309; 72650 -TBK1 TBK1 Q9UHD2 human Nik 53859 Q9WUL6 Map3k14 mouse T690 27259007 TCHQTLPtPPRENPP X -TBK1 TBK1 Q9UHD2 human Tau iso8 4137 P10636-8 MAPT human S198 449551 sGDRsGyssPGsPGt X -TBK1 TBK1 Q9UHD2 human IRF3 3661 Q14653 IRF3 human T404 449031 NsHPLsLtsDQYKAY X X -TBK1 TBK1 Q9UHD2 human IRF3 3661 Q14653 IRF3 human S386 448684 ARVGGAssLENtVDL X X 37829; 73981; 96421; 91968 -TBK1 TBK1 Q9UHD2 human TRAF3IP2 103213 Q8N7N6 Traf3ip2 mouse S222 25687505 DLPGPLRsRELPPQF X X -TBK1 TBK1 Q9UHD2 human mTOR 56717 Q9JLN9 Mtor mouse S2159 20473601 RIQSIAPsLQVITSK X X -TBK1 TBK1 Q9UHD2 human LC3C 440738 Q9BXW4 MAP1LC3C human S96 1869546301 VNNKsLVsMSATMAE ATG8 X X -TBK1 TBK1 Q9UHD2 human DDAH2 23564 O95865 DDAH2 human T203 1872776102 VRAMAVLtDHPyASL X -TBK1 TBK1 Q9UHD2 human E2F1 1869 Q01094 E2F1 human S332 447868 TDSATIVsPPPSsPP X -TBK1 TBK1 Q9UHD2 human CXCR4 12767 P70658 Cxcr4 mouse S355 3193348 sTESEsssFHSs___ X -TBK1 TBK1 Q9UHD2 human PELI1 57162 Q96FA3 PELI1 human T288 7388016 QCPVGFNtLAFPsMk Pellino X -TBK1 TBK1 Q9UHD2 human Tau iso8 4137 P10636-8 MAPT human S214 447929 GsRsRtPsLPtPPtR X X 77348 -TBK1 TBK1 Q9UHD2 human Huntingtin 3064 P42858 HTT human S13 10206805 kLMkAFEsLksFQQQ X X -TBK1 TBK1 Q9UHD2 human IRF7 3665 Q92985 IRF7 human S477 1276101 VssLDSSsLsLCLsS X 12390 -TBK1 TBK1 Q9UHD2 human IRF3 3661 Q14653 IRF3 human S396 449028 NtVDLHIsNsHPLsL X X 4947; 29047; 83611; 10327; 53539; 81093; 52270; 61166 -TBK1 TBK1 Q9UHD2 human Nik 53859 Q9WUL6 Map3k14 mouse S752 27259006 PATAKGPsFPDRRAT X -TBK1 TBK1 Q9UHD2 human Tau iso8 4137 P10636-8 MAPT human S356 449104 rVQskIGsLDNItHV Tubulin-binding X X -TBK1 TBK1 Q9UHD2 human Tau iso8 4137 P10636-8 MAPT human S285 487455 INkkLDLsNVQskCG Tubulin-binding X X -TBK1 TBK1 Q9UHD2 human IRF7 3665 Q92985 IRF7 human S471 1276102 GTQREGVssLDSSsL X 5184 -TBK1 TBK1 Q9UHD2 human SIKE 80143 Q9BRV8 SIKE1 human S185 28076410 kELRELLsIssEsLQ SIKE X -TBK1 TBK1 Q9UHD2 human NRF1 18181 Q9WU00 Nrf1 mouse S318 1883500600 SNPDGTVsLIQVGTG X -TBK1 TBK1 Q9UHD2 human DDAH2 23564 O95865 DDAH2 human S245 1872776106 GGGDLPNsQEALQKL X -TBK1 TBK1 Q9UHD2 human Akt1 207 P31749 AKT1 human S473 447855 RPHFPQFsysAsGtA Pkinase_C X X 9271; 3787; 4060; 4051; 5102; 4058; 2336; 2337; 4075; 4070; 5012; 4071; 92982; 5315; 9563; 9018; 12694; 52240; 11962; 15116; 88106; 26580; 68035; 31957; 23430; 20235 -TBK1 TBK1 Q9UHD2 human TRIM56 81844 Q9BRZ2 TRIM56 human T442 4269997 LEEDRAQtPHEDGGP X -TBK1 TBK1 Q9UHD2 human STAT6 6778 P42226 STAT6 human S407 21561700 PIQLQALsLPLVVIV STAT_bind X X -TBK1 TBK1 Q9UHD2 human PRPS2 5634 P11908 PRPS2 human T228 1874512700 DMADtCGtICHAADk Pribosyl_synth X X -TBK1 TBK1 Q9UHD2 human STX17 55014 P56962 STX17 human S202 102898200 SQQEKIDsIADHVNS SNARE X 28630 -TBK1 TBK1 Q9UHD2 human mTOR 2475 P42345 MTOR human S2159 20473601 RIQsIAPsLQVItSk X X -TBK1 TBK1 Q9UHD2 human Tau iso8 4137 P10636-8 MAPT human T30 1873559802 RKDQGGytMHQDQEG X X -TBK1 TBK1 Q9UHD2 human TBK1 29110 Q9UHD2 TBK1 human S172 447732 EDDEQFVsLyGTEEy Pkinase X X 5483; 13498; 14590; 14586; 54382; 70483; 20399 -TBK1 TBK1 Q9UHD2 human IRF7 3665 Q92985 IRF7 human S472 1276103 TQREGVssLDSSsLs X 5184 -TBK1 TBK1 Q9UHD2 human Raptor 57521 Q8N122 RPTOR human S877 3205938 HIHQAGGsPPAssts X X -TBK1 TBK1 Q9UHD2 human SMCR8 140775 Q8TEV9 SMCR8 human S402 55469601 QDRPPsSsLEECPIP X -TBK1 TBK1 Q9UHD2 human SIKE 80143 Q9BRV8 SIKE1 human S198 28076406 LQARkENsMDTASQA X -TBK1 TBK1 Q9UHD2 human p70S6K 6198 P23443 RPS6KB1 human T444 448358 RFIGsPRtPVsPVkF X 9204 -TBK1 TBK1 Q9UHD2 human Nik 53859 Q9WUL6 Map3k14 mouse S862 27259003 GVKVQIQsLNGEHLH X -TBK1 TBK1 Q9UHD2 human IRF3 3661 Q14653 IRF3 human S398 449029 VDLHIsNsHPLsLts X X -TBK1 TBK1 Q9UHD2 human IRF5 3663 Q13568 IRF5 human S293 27101101 VELFGPIsLEQVRFP IRF-3 X X -TBK1 TBK1 Q9UHD2 human Tau iso8 4137 P10636-8 MAPT human S324 449328 kVtskCGsLGNIHHk Tubulin-binding X X -TBK1 TBK1 Q9UHD2 human Nik 53859 Q9WUL6 Map3k14 mouse S357 27259012 GQAHsLAsLAKTWSS X -TBK1 TBK1 Q9UHD2 human Tau iso8 4137 P10636-8 MAPT human S289 487456 LDLsNVQskCGsKDN Tubulin-binding X X -TBK1 TBK1 Q9UHD2 human HDAC3 8841 O15379 HDAC3 human S424 455624 DHDNDKEsDVEI___ X 3815 -TBK1 TBK1 Q9UHD2 human Nik 53859 Q9WUL6 Map3k14 mouse S728 27259004 KAPALNLsKEESGTW X -TBK1 TBK1 Q9UHD2 human PELI1 57162 Q96FA3 PELI1 human S293 7388014 FNtLAFPsMkRkDVV Pellino X -TBK1 TBK1 Q9UHD2 human SIKE 80143 Q9BRV8 SIKE1 human S188 28076408 RELLsIssEsLQARk X -TBK1 TBK1 Q9UHD2 human Nik 53859 Q9WUL6 Map3k14 mouse S821 27259011 SsRDTLssGVHSWNS X -TBK1 TBK1 Q9UHD2 human XIAP 331 P98170 XIAP human S430 22547400 QDESSQtsLQkEIst X X -TBK1 TBK1 Q9UHD2 human NRF1 18181 Q9WU00 Nrf1 mouse S384 1883500602 EATQAVAsLAEAAVA X -TBK1 TBK1 Q9UHD2 human TICAM1 148022 Q8IUC6 TICAM1 human S210 31858079 LAsNLEIsQsPTMPF X -TBK1 TBK1 Q9UHD2 human Akt1 11651 P31750 Akt1 mouse S473 447855 RPHFPQFsysAsGtA Pkinase_C X 9271; 3787; 4060; 4051; 5102; 4058; 2336; 2337; 4075; 4070; 5012; 4071; 92982; 5315; 9563; 9018; 12694; 52240; 11962; 15116; 88106; 26580; 68035; 31957; 23430; 20235 -TBK1 TBK1 Q9UHD2 human SIKE 80143 Q9BRV8 SIKE1 human S133 28076407 PVLkAHQsHSAEIES SIKE X -TBK1 TBK1 Q9UHD2 human PBXIP1 57326 Q96AQ6 PBXIP1 human S147 471206 REEGRCsssDDDtDV X X -TBK1 TBK1 Q9UHD2 human NFkB-p65 5970 Q04206 RELA human S536 447800 sGDEDFSsIADMDFS X X 4887; 3036; 3031; 4886; 3033; 4025; 5733; 13346; 76778; 31553; 80477; 73992; 87672; 83962 -TBK1 TBK1 Q9UHD2 human METTL3 56339 Q86U44 METTL3 human S67 1876371800 GPKPSTAsAVPELAT X X -TBK1 TBK1 Q9UHD2 human CTNNB1 1499 P35222 CTNNB1 human S552 472273 QDtQRRtsMGGtQQQ X 9566; 5651 -TBK1 TBK1 Q9UHD2 human Nik 53859 Q9WUL6 Map3k14 mouse S89 27259005 AQAECENsQEFSPTF X -TBK1 TBK1 Q9UHD2 human MAVS 57506 Q7Z434 MAVS human S442 58984003 CFEDLAIsASTSLGM X X -TBK1 TBK1 Q9UHD2 human MCPIP1 230738 Q5D1E7 Zc3h12a mouse S513 34505699 YPSREYWsEPYPLPP X -TBK1 TBK1 Q9UHD2 human Nik 53859 Q9WUL6 Map3k14 mouse S113 27259010 QQYSQSEsLDQIPNN X -TBK1 TBK1 Q9UHD2 human Nik 53859 Q9WUL6 Map3k14 mouse S820 27259002 QSsRDTLssGVHSWN X -TBK1 TBK1 Q9UHD2 human Raptor 74370 Q8K4Q0 Rptor mouse S877 3205938 HMHQVGGsPPASsts X X -TBK1 TBK1 Q9UHD2 human Tau iso8 4137 P10636-8 MAPT human S191 487448 ssGEPPKsGDRsGys X -TBK1 TBK1 Q9UHD2 human IRF7 3665 Q92985 IRF7 human S479 2868600 sLDSSsLsLCLsSAN X -TBK1 TBK1 Q9UHD2 human STAT3 20848 P42227 Stat3 mouse S754 35494901 SAGGQFEsLTFDMDL X X 98543 -TBK1 TBK1 Q9UHD2 human NFkB-p65 19697 Q04207 Rela mouse S534 447800 sGDEDFssIADMDFS X 4887; 3036; 3031; 4886; 3033; 4025; 5733; 13346; 76778; 31553; 80477; 73992; 87672; 83962 -TBK1 TBK1 Q9UHD2 human PELI1 57162 Q96FA3 PELI1 human S76 7388015 IsNKDQHsIsYtLsR Pellino X -TBK1 TBK1 Q9UHD2 human Huntingtin 3064 P42858 HTT human S16 12056100 kAFEsLksFQQQQQQ X X -TBK1 TBK1 Q9UHD2 human IRF3 3661 Q14653 IRF3 human S402 449030 IsNsHPLsLtsDQYK X X -TBK1 TBK1 Q9UHD2 human optineurin 10133 Q96CV9 OPTN human S513 21214714 FEDGGRQsLMEMQsR X X -TBK1 TBK1 Q9UHD2 human INSR 24954 P15127 Insr rat S1034 454090 LRELGQGsFGMVYEG PK_Tyr_Ser-Thr X -TBK1 TBK1 Q9UHD2 human LC3C 440738 Q9BXW4 MAP1LC3C human S93 1869546300 YLLVNNKsLVsMSAT ATG8 X X -TBK1 TBK1 Q9UHD2 human IRF3 3661 Q14653 IRF3 human S385 448696 MARVGGAssLENtVD X -TBK1 TBK1 Q9UHD2 human RKIP 5037 P30086 PEBP1 human S109 59070500 VLsDyVGsGPPkGTG PBP X X -TBK1 TBK1 Q9UHD2 human IRF3 3661 Q14653 IRF3 human S175 14567912 PQPLRsPsLDNPtPF X -TBK1 TBK1 Q9UHD2 human STAT2 6773 P52630 STAT2 human T404 1869973803 IWDFGYLtLVEQRSG STAT_bind X -TBK1 TBK1 Q9UHD2 human Akt1 11651 P31750 Akt1 mouse T308 447856 KDGAtMKtFCGtPEy Pkinase X 5106; 2965; 9275; 4056; 5056; 13842; 13038; 43506; 48646; 86758; 80722; 77440; 80556 -TBK1 TBK1 Q9UHD2 human TRAF3IP2 103213 Q8N7N6 Traf3ip2 mouse S209 25687506 ERPLPLTsSCYLQDL X X -TBK1 TBK1 Q9UHD2 human MCPIP1 230738 Q5D1E7 Zc3h12a mouse S494 56659543 AMGAGHFsVPTDYVP X -TBK1 TBK1 Q9UHD2 human ER-alpha 2099 P03372 ESR1 human S305 448805 IkRSkkNsLALSLtA X -TBK1 TBK1 Q9UHD2 human STING 340061 Q86WV6 STING1 human S358 13201900 VPStstMsQEPELLI X -TBK1 TBK1 Q9UHD2 human optineurin 71648 Q8K3K8 Optn mouse S187 4762451 SGGSsEDsFVEIRMT X 31304 -TBK1 TBK1 Q9UHD2 human IRF3 3661 Q14653 IRF3 human S173 6370303 PCPQPLRsPsLDNPt X -TBK1 TBK1 Q9UHD2 human Nik 53859 Q9WUL6 Map3k14 mouse S48 27259009 KLEAVEKsPVFCGKW X -TBK1 TBK1 Q9UHD2 human TNIP1 10318 Q15025 TNIP1 human S122 1880462800 KPPSSGTssEFEVVT X X -TBK1 TBK1 Q9UHD2 human TRAF3IP2 103213 Q8N7N6 Traf3ip2 mouse S147 25687507 ESDKSDPsLPNALAD X X -TBK1 TBK1 Q9UHD2 human SIKE 80143 Q9BRV8 SIKE1 human S187 28076409 LRELLsIssEsLQAR SIKE X -TBK1 TBK1 Q9UHD2 human SQSTM1 8878 Q13501 SQSTM1 human S366 476290 PEsEGPssLDPsQEG X X 26317 -TBK1 TBK1 Q9UHD2 human SIKE 80143 Q9BRV8 SIKE1 human S190 28076405 LLsIssEsLQARkEN X -TBK1 TBK1 Q9UHD2 human IRF5 3663 Q13568 IRF5 human S158 27101102 QRMLPSLsLTEDVKW X X -TBK1 TBK1 Q9UHD2 human Tau iso8 4137 P10636-8 MAPT human S305 487457 kHVPGGGsVQIVykP Tubulin-binding X X -TBK1 TBK1 Q9UHD2 human IRF3 3661 Q14653 IRF3 human S405 449032 sHPLsLtsDQYKAYL X X -TBK1 TBK1 Q9UHD2 human Nik 53859 Q9WUL6 Map3k14 mouse S153 27259001 RRKKRSKsLAQAGVA X -TBK1 TBK1 Q9UHD2 human Akt1 207 P31749 AKT1 human T308 447856 kDGAtMKtFCGtPEy Pkinase X X 5106; 2965; 9275; 4056; 5056; 13842; 13038; 43506; 48646; 86758; 80722; 77440; 80556 -TBK1 TBK1 Q9UHD2 human DDAH2 23564 O95865 DDAH2 human T211 1872776104 DHPyASLtLPDDAAA X -Hipk3 HIPK3 Q9ERH7 mouse AML3 iso5 12393 Q08775-5 Runx2 mouse T326 14694701 sPSIHSTtPLSSTRG X X -Hipk3 HIPK3 Q9ERH7 mouse AML3 iso5 12393 Q08775-5 Runx2 mouse S319 10892802 SYLSQMTsPSIHSTt X X -TEK TIE2 Q02763 human TIE2 7010 Q02763 TEK human Y992 448373 LSRGQEVyVKKtMGR PK_Tyr_Ser-Thr X 4221 -TEK TIE2 Q02763 human TIE2 7010 Q02763 TEK human Y1108 448372 TyVNTTLyEKFTyAG X -Rps6ka3 RSK2 NP_001178933 rat BSN 29138 O88778 Bsn rat S2845 456576 KTLQRSLsDPKPLSP X -Rps6ka3 RSK2 NP_001178933 rat nNOS 24598 P29476 Nos1 rat S847 447886 SYKVRFNsVSSYSDS Flavodoxin_1 X X -Rps6ka3 RSK2 NP_001178933 rat PLD1 25096 P70496 Pld1 rat T147 448573 PIPTKRHtFRRQNVK PX X 3831 -Rps6ka3 RSK2 NP_001178933 rat MEF2A 309957 Q2MJT0 Mef2a rat S192 7533201 ATLHRNVsPGAPQRP X X -Rps6ka3 RSK2 NP_001178933 rat BSN 12217 O88737 Bsn mouse S2860 456576 KTLQRsLsDPKPLsP X -Rps6ka3 RSK2 NP_001178933 rat Fos 2353 P01100 FOS human S362 448481 AAAHRKGssSNEPSS X -PRKD3 PRKD3 O94806 human HDAC5 10014 Q9UQL6 HDAC5 human S498 447996 RPLSRtQsSPLPQsP X 3424 -PRKD3 PRKD3 O94806 human PRKD1 5587 Q15139 PRKD1 human S738 448589 ARIIGEksFRRsVVG Pkinase X 2054 -PRKD3 PRKD3 O94806 human Cortactin 2017 Q14247 CTTN human S298 5014901 EKLAkHEsQQDyskG HS1_rep X -PRKD3 PRKD3 O94806 human GIT1 28964 Q9Y2X7 GIT1 human S46 25784901 RSLGRHIsIVkHLRH ArfGap X X -PRKD3 PRKD3 O94806 human PRKD1 5587 Q15139 PRKD1 human S742 448590 GEksFRRsVVGtPAy Pkinase X -PRKD3 PRKD3 O94806 human MFF 56947 Q9GZY8 MFF human S172 484865 GQLVRNDsLWHRsDs Miff X -CSF1R CSFR P07333 human CSFR 1436 P07333 CSF1R human Y809 448365 DIMNDSNyIVkGNAR PK_Tyr_Ser-Thr X X 3154 -CSF1R CSFR P07333 human CSFR 1436 P07333 CSF1R human Y561 450118 EsyEGNsytFIDPtQ X -CSF1R CSFR P07333 human CSFR 1436 P07333 CSF1R human Y699 451527 DPEGGVDyKNIHLEK PK_Tyr_Ser-Thr X 3399; 12251 -CSF1R CSFR P07333 human CSFR 1436 P07333 CSF1R human Y546 2866400 KYKQKPKyQVRWKII X 3083 -PRKCB PKCB iso2 P05771-2 human Tau iso8 4137 P10636-8 MAPT human S352 487459 DFKDrVQskIGsLDN Tubulin-binding X -PRKCB PKCB iso2 P05771-2 human ITGB2 3689 P05107 ITGB2 human S745 448532 FEkEKLksQWNNDNP Integrin_b_cyt X -PRKCB PKCB iso2 P05771-2 human TRPV1 7442 Q8NER1 TRPV1 human T705 487542 WKLQRAItILDTEKS X -PRKCB PKCB iso2 P05771-2 human DAB2 1601 P98082 DAB2 human S24 451211 QAAPKAPsKKEKKKG X -PRKCB PKCB iso2 P05771-2 human PKCB iso2 5579 P05771-2 PRKCB human S660 1869073011 QsEFEGFsFVNsEFL Pkinase_C X X 9371 -PRKCB PKCB iso2 P05771-2 human CACNA1B 257648 Q02294 Cacna1b rat S1757 465548 FEMLKHMsPPLGLGK GPHH X -PRKCB PKCB iso2 P05771-2 human Tau iso8 4137 P10636-8 MAPT human S258 487453 PDLkNVKskIGstEN Tubulin-binding X -PRKCB PKCB iso2 P05771-2 human PPAR-alpha 5465 Q07869 PPARA human S230 2902207 VKARVILsGKASNNP X -PRKCB PKCB iso2 P05771-2 human CACNA1C 100101555 P15381 CACB rabbit S1928 455278 ASLGRRAsFHLECLK CAC1F_C X -PRKCB PKCB iso2 P05771-2 human CACNA1B 257648 Q02294 Cacna1b rat S2108 465549 RKQERGRsQERRQPS X -PRKCB PKCB iso2 P05771-2 human ATF-2 1386 P15336 ATF2 human S121 6406001 LAtPIIRsKIEEPSV X -PRKCB PKCB iso2 P05771-2 human KIR3DL1 3811 P43629 KIR3DL1 human S415 990302 QRKITRPsQRPKtPP X -PRKCB PKCB iso2 P05771-2 human EIF6 3692 P56537 EIF6 human S235 450271 QPstIAtsMRDsLID X -PRKCB PKCB iso2 P05771-2 human SHP-2 5781 Q06124 PTPN11 human S591 469623 GLMQQQksFR_____ X -PRKCB PKCB iso2 P05771-2 human GSK3B 2932 P49841 GSK3B human S9 449111 SGRPRttsFAEsCkP X 9336; 9331; 9327; 9323; 9322; 9325; 5558; 8566; 79774; 8466; 25462; 14026; 14332; 14310; 14630 -PRKCB PKCB iso2 P05771-2 human MYH9 4627 P35579 MYH9 human S1916 451181 AMNREVssLkNkLRr Myosin_tail_1 X -PRKCB PKCB iso2 P05771-2 human CKM 24265 P00564 Ckm rat S128 5410301 LDPNyVLssRVRTGR X -PRKCB PKCB iso2 P05771-2 human CACNA1B 257648 Q02294 Cacna1b rat S2132 465550 YsCDRFGsREPPQPK X -PRKCB PKCB iso2 P05771-2 human P70S6KB 6199 Q9UBS0 RPS6KB2 human S473 450071 PPSGTKKsKRGRGRP X -PRKCB PKCB iso2 P05771-2 human ITGB2 3689 P05107 ITGB2 human T758 448533 NPLFksAtttVMNPk Integrin_b_cyt X -PRKCB PKCB iso2 P05771-2 human JNK2 26420 Q9WTU6 Mapk9 mouse S129 456485 ELDHERMsYLLYQML Pkinase X -PRKCB PKCB iso2 P05771-2 human TRPV6 55503 Q9H1D0 TRPV6 human S184 12173901 LARRAsVsARAtGTA Ank_2 X -PRKCB PKCB iso2 P05771-2 human C5aR 728 P21730 C5AR1 human S334 448819 sVVREsKsFTRsTVD X X -PRKCB PKCB iso2 P05771-2 human p47phox 653361 P14598 NCF1 human S320 451726 QRsRKRLsQDAYRRN NECFESHC X -PRKCB PKCB iso2 P05771-2 human MFN1 55669 Q8IWA4 MFN1 human S284 1871247400 QNRIFFVsAkEVLsA X -PRKCB PKCB iso2 P05771-2 human MOR-1 18390 P42866 Oprm1 mouse S363 447783 STIEQQNsARIRQNt X -PRKCB PKCB iso2 P05771-2 human eIF3-theta 8661 Q14152 EIF3A human S1364 487404 RAEKDREsLRRtKNE X -PRKCB PKCB iso2 P05771-2 human Lamin B1 4001 P20700 LMNB1 human S405 448733 VtVsRAsssRsVRtt X X -PRKCB PKCB iso2 P05771-2 human CACNA1C 100101555 P15381 CACB rabbit S528 486358 ARLAHRIsKSKFsRY X -PRKCB PKCB iso2 P05771-2 human SYT6 148281 Q5T7P8 SYT6 human T418 456499 RLKKKKttIKKNTLN C2 X -PRKCB PKCB iso2 P05771-2 human MCU 90550 Q8NE86 MCU human S92 27259017 VISVRLPsRRERCQF X -PRKCB PKCB iso2 P05771-2 human eIF4G iso8 1981 Q04637-8 EIF4G1 human S1093 3194291 FAPGGRLsWGKGSSG X -PRKCB PKCB iso2 P05771-2 human AID 11628 Q9WVE0 Aicda mouse S3 20660600 _____MDsLLMKQKK X -PRKCB PKCB iso2 P05771-2 human CACNA1C 100101555 P15381 CACB rabbit S533 453091 RIsKSKFsRYWRRWN X -PRKCB PKCB iso2 P05771-2 human MFN1 55669 Q8IWA4 MFN1 human S290 1871247401 VsAkEVLsARKQKAQ X -PRKCB PKCB iso2 P05771-2 human SHP-2 5781 Q06124 PTPN11 human S576 469622 CAEMREDsARVyENV X -PRKCB PKCB iso2 P05771-2 human p47phox 653361 P14598 NCF1 human S315 451725 AHsIHQRsRKRLsQD NECFESHC X -PRKCB PKCB iso2 P05771-2 human TRPV6 55503 Q9H1D0 TRPV6 human T728 12173902 MPSVSRstSRssANW X -PRKCB PKCB iso2 P05771-2 human RAB11A 8766 P62491 RAB11A human S177 22826101 TEIYRIVsQkQMSDR X -PRKCB PKCB iso2 P05771-2 human MFN1 192647 Q8R4Z9 Mfn1 rat S86 1498941800 AFFGRTSsGKSSVIN Dynamin_N X X -PRKCB PKCB iso2 P05771-2 human PPAR-alpha 5465 Q07869 PPARA human S179 457549 RFGRMPRsEKAKLkA X -PRKCB PKCB iso2 P05771-2 human TNNI3 29248 P23693 Tnni3 rat S23 448423 PAPVRRRssANYRAY Troponin-I_N X 4004 -PRKCB PKCB iso2 P05771-2 human p47phox 653361 P14598 NCF1 human S328 449404 QDAYRRNsVRFLQQR NECFESHC X -PRKCB PKCB iso2 P05771-2 human Tau iso8 4137 P10636-8 MAPT human S324 449328 kVtskCGsLGNIHHk Tubulin-binding X -PRKCB PKCB iso2 P05771-2 human p73 7161 O15350 TP73 human S388 6417400 VPQPLVDsYRQQQQL X -PRKCB PKCB iso2 P05771-2 human CHAT iso3 1103 P28329-3 CHAT human S476 454037 HKAAVPAsEKLLLLK Carn_acyltransf X -PRKCB PKCB iso2 P05771-2 human CACNA1B 257648 Q02294 Cacna1b rat S425 465547 KRAAtKKsRNDLIHA X -PRKCB PKCB iso2 P05771-2 human Lamin B1 4001 P20700 LMNB1 human S395 448732 LkLsPsPssRVtVsR X X -PRKCB PKCB iso2 P05771-2 human TNNI3 29248 P23693 Tnni3 rat S24 448424 APVRRRssANYRAYA Troponin-I_N X 4004 -PRKCB PKCB iso2 P05771-2 human CACNA1D 29716 P27732 Cacna1d rat S81 470135 PPPVGSLsQRKRQQY X -PRKCB PKCB iso2 P05771-2 human CHAT iso3 1103 P28329-3 CHAT human S346 454035 LLKHVTQssRKLIRA Carn_acyltransf X -PRKCB PKCB iso2 P05771-2 human CHAT iso3 1103 P28329-3 CHAT human S440 449057 VPTYESAsIRRFQEG Carn_acyltransf X -PRKCB PKCB iso2 P05771-2 human hnRNP P2 2521 P35637 FUS human S257 450486 GrGGMGGsDrGGFNk X -PRKCB PKCB iso2 P05771-2 human CACNA1B 257648 Q02294 Cacna1b rat T422 465546 AVLKRAAtKKsRNDL X -PRKCB PKCB iso2 P05771-2 human SYT6 148281 Q5T7P8 SYT6 human T417 456500 RRLKKKKttIKKNTL C2 X -PRKCB PKCB iso2 P05771-2 human CHAT iso3 1103 P28329-3 CHAT human S347 454036 LKHVTQssRKLIRAD Carn_acyltransf X -PRKCB PKCB iso2 P05771-2 human CHAT iso3 1103 P28329-3 CHAT human T255 454038 TVLVKDStNRDSLDM Carn_acyltransf X -PRKCB PKCB iso2 P05771-2 human p47phox 653361 P14598 NCF1 human S370 451730 PAVPPRPsADLILNR p47_phox_C X -PRKCB PKCB iso2 P05771-2 human MYH9 25745 Q62812 Myh9 rat S1917 451181 AMNREVSsLKNKLRR Myosin_tail_1 X X -PRKCB PKCB iso2 P05771-2 human p47phox 653361 P14598 NCF1 human S303 449405 RGAPPRRssIRNAHs NECFESHC X -PRKCB PKCB iso2 P05771-2 human mGluR5 24418 P31424 Grm5 rat S839 455778 VRSAFTTstVVRMHV X -PRKCB PKCB iso2 P05771-2 human ghrelin 51738 Q9UBU3 GHRL human S41 2235100 RVQQRKEsKKPPAKL Motilin_ghrelin X -PRKCB PKCB iso2 P05771-2 human Tau iso8 4137 P10636-8 MAPT human S293 449327 NVQskCGsKDNIkHV Tubulin-binding X -PRKCB PKCB iso2 P05771-2 human CACNA1C 100101555 P15381 CACB rabbit S1674 480102 QGLVGKPsQRNALSL X -PRKCB PKCB iso2 P05771-2 human MFN1 67414 Q811U4 Mfn1 mouse S86 1498941800 AFFGRTSsGKSSVIN Dynamin_N X X -PRKCB PKCB iso2 P05771-2 human KCNE1 3753 P15382 KCNE1 human S102 10349700 VQARVLEsYRSCYVV ISK_Channel X -PRKCB PKCB iso2 P05771-2 human p47phox 653361 P14598 NCF1 human S359 451729 EERQtQRsKPQPAVP p47_phox_C X -PRKCB PKCB iso2 P05771-2 human p47phox 653361 P14598 NCF1 human S304 449406 GAPPRRssIRNAHsI NECFESHC X -PRKCB PKCB iso2 P05771-2 human MFN1 55669 Q8IWA4 MFN1 human S86 1498941800 AFFGRTSsGKSSVIN Dynamin_N X X -PRKCB PKCB iso2 P05771-2 human GSK3A 2931 P49840 GSK3A human S21 448584 sGrARtssFAEPGGG X 9337; 9316; 9331; 5090; 9327; 8452; 8566 -PRKCB PKCB iso2 P05771-2 human p47phox 653361 P14598 NCF1 human S379 451498 DLILNRCsEstKRKL p47_phox_C X -PRKCB PKCB iso2 P05771-2 human SYT6 148281 Q5T7P8 SYT6 human T283 456501 DRKCKLQtRVHRKTL C2 X -Cdk8 CDK8 Q8R3L8 mouse STAT3 20848 P42227 Stat3 mouse Y705 448192 DPGsAAPyLktkFIC X 4093; 9145; 4324; 9131; 9138; 4323; 4074; 4113; 48313; 20977; 25023; 8119; 52075; 52527; 73533; 61958; 73452; 16185; 74309 -Cdk8 CDK8 Q8R3L8 mouse OSBPL3 iso3 71720 D3Z194 Osbpl3 mouse S302 3212430 SGPVRLHssNPNLST X -Cdk8 CDK8 Q8R3L8 mouse OSBPL3 iso3 71720 D3Z194 Osbpl3 mouse S303 3212433 GPVRLHssNPNLSTL X -Cdk8 CDK8 Q8R3L8 mouse OSBPL3 iso3 71720 D3Z194 Osbpl3 mouse S250 3212427 DVLHRtYsAPAINAI X -Cdk8 CDK8 Q8R3L8 mouse OSBPL3 iso3 71720 D3Z194 Osbpl3 mouse T248 6209017 SMDVLHRtYsAPAIN X -Cdk8 CDK8 Q8R3L8 mouse STAT1 20846 P42225 Stat1 mouse S727 447753 tDNLLPMsPEEFDEM STAT1_TAZ2bind X 9177; 8826; 62390 -Cdk8 CDK8 Q8R3L8 mouse STAT5A 20850 P42230 Stat5a mouse S725 448749 TYMDQAPsPVVCPQP X -SYK Syk P43405 human STAT3 20848 P42227 Stat3 mouse Y705 448192 DPGsAAPyLktkFIC X 4093; 9145; 4324; 9131; 9138; 4323; 4074; 4113; 48313; 20977; 25023; 8119; 52075; 52527; 73533; 61958; 73452; 16185; 74309 -SYK Syk P43405 human Syk 20963 P48025 Syk mouse Y317 447658 STVSFNPyEPtGGPW X 2715 -SYK Syk P43405 human SLC4A1 6521 P02730 SLC4A1 human Y904 455304 EEEGRDEyDEVAMPV X -SYK Syk P43405 human PKM 18746 P52480 Pkm mouse Y105 450528 FAsDPILyRPVAVAL PK X 3827 -SYK Syk P43405 human GCET2 257144 Q8N6F7 GCSAM human Y106 463673 sGNsAEEyyENVPCk HGAL X -SYK Syk P43405 human SHC1 iso2 6464 P29353-2 SHC1 human Y317 448511 ELFDDPSyVNVQNLD X -SYK Syk P43405 human FCGR2C 9103 P31995 FCGR2C human Y310 449501 tDDDKNIyLTLPPND X -SYK Syk P43405 human DBNL 13169 Q62418 Dbnl mouse Y340 450090 QTEEEPTyEVPPEQD X -SYK Syk P43405 human PRDX2 7001 P32119 PRDX2 human Y193 448985 NVDDskEyFskHN__ 1-cysPrx_C X X -SYK Syk P43405 human SLC4A1 6521 P02730 SLC4A1 human Y21 457533 ENLEQEEyEDPDIPE X X -SYK Syk P43405 human LAX1 54900 Q8IWV1 LAX1 human Y268 35546002 SSQISNDyVNMTGLD LAX X -SYK Syk P43405 human SLC4A1 6521 P02730 SLC4A1 human Y8 451570 MEELQDDyEDMMEEN X X -SYK Syk P43405 human PLCG1 5335 P19174 PLCG1 human Y771 448575 IGtAEPdyGALyEGR X -SYK Syk P43405 human BLNK 29760 Q8WV28 BLNK human Y96 447719 EENADDSyEPPPVEQ X X 3601 -SYK Syk P43405 human PLCG2 5336 P16885 PLCG2 human Y759 447941 LyDVsRMyVDPsEIN X 3874; 50535 -SYK Syk P43405 human HS1 3059 P14317 HCLS1 human Y378 451635 EPEPENDyEDVEEMD X X -SYK Syk P43405 human SHC1 iso2 6464 P29353-2 SHC1 human Y239 448509 EEPPDHQyyNDFPGK X X -SYK Syk P43405 human FCGR2A 2212 P12318 FCGR2A human Y304 449552 tDDDKNIyLTLPPND X -SYK Syk P43405 human Ikaros 10320 Q13422 IKZF1 human S361 14160239 LAEGtPRsNHsAQDs X -SYK Syk P43405 human CFTR 1080 P13569 CFTR human Y512 21041602 NIIFGVsyDEyRYRS ABC_tran X X -SYK Syk P43405 human LAB 7462 Q9GZY6 LAT2 human Y233 450646 EEDGEPDyVNGEVAA LAT2 X -SYK Syk P43405 human Ikaros 10320 Q13422 IKZF1 human S364 4714822 GtPRsNHsAQDsAVE X -SYK Syk P43405 human Syk 25155 Q64725 Syk rat Y520 447662 LRADENyyKAQTHGK PK_Tyr_Ser-Thr X 2710; 12967; 5514; 4349; 6485; 12081; 46994; 16859 -SYK Syk P43405 human DEPTOR 64798 Q8TB45 DEPTOR human Y289 1875073002 ssCGssGyFsssPtL X -SYK Syk P43405 human Cortactin 2017 Q14247 CTTN human Y421 447702 rLPssPVyEDAAsFK X 4569 -SYK Syk P43405 human TLR2 24088 Q9QUN7 Tlr2 mouse Y647 1876860404 CYDAFVSySEQDSHW TIR X -SYK Syk P43405 human RhoGDI beta 397 P52566 ARHGDIB human Y24 448978 ELdskLNykPPPQks Rho_GDI X -SYK Syk P43405 human BLNK 29760 Q8WV28 BLNK human Y84 449841 EHSDSEMyVMPAEEN X X 65060; 26528 -SYK Syk P43405 human PLCG1 5335 P19174 PLCG1 human Y783 447667 EGRNPGFyVEANPMP X 2821; 14461; 14008; 25678; 88717 -SYK Syk P43405 human STAT5A 6776 P42229 STAT5A human Y694 447767 LAkAVDGyVkPQIkQ X 9365; 9356; 9359; 9351; 4322; 9314; 3939; 40284; 5387; 14603; 66740; 51879; 72712 -SYK Syk P43405 human LAB 7462 Q9GZY6 LAT2 human Y193 450645 EDEEsEDyQNsAsIH LAT2 X -SYK Syk P43405 human CBL 867 P22681 CBL human Y700 448529 EGEEDtEyMtPssRP X 8869 -SYK Syk P43405 human PKACA 18747 P05132 Prkaca mouse Y331 15230353 DTSNFDDyEEEEIRV X X -SYK Syk P43405 human FCGR2C 9103 P31995 FCGR2C human Y287 449556 PEETNNDyETADGGy X -SYK Syk P43405 human GCET2 257144 Q8N6F7 GCSAM human Y86 449473 tysEELCytLINHRV HGAL X -SYK Syk P43405 human SLC4A1 6521 P02730 SLC4A1 human Y359 455384 AKPDssFyKGLDLNG X -SYK Syk P43405 human SNCA 6622 P37840 SNCA human Y133 448280 EMPsEEGyQDyEPEA X X -SYK Syk P43405 human RIP140 268903 Q8CBD1 Nrip1 mouse Y418 25234800 TPTTIDEySDNNPSF NRIP1_repr_2 X X -SYK Syk P43405 human SHC1 iso2 6464 P29353-2 SHC1 human Y240 448510 EPPDHQyyNDFPGKE X X -SYK Syk P43405 human LAB 7462 Q9GZY6 LAT2 human Y136 450963 EDDDANsyENVLICK LAT2 X -SYK Syk P43405 human Ig-alpha 12518 P11911 Cd79a mouse S197 21127303 CsMyEDIsRGLQGty ITAM X X -SYK Syk P43405 human SNCA 6622 P37840 SNCA human Y136 448281 sEEGyQDyEPEA___ X X -SYK Syk P43405 human PYCARD 66824 Q9EPB4 Pycard mouse Y144 465096 SVLTEGQyQAVRAET CARD X X -SYK Syk P43405 human RIP140 268903 Q8CBD1 Nrip1 mouse Y364 25234802 SsPKNTSyKNSLERN X X -SYK Syk P43405 human DUSP3 1845 P51452 DUSP3 human Y138 448718 SPTLVIAyLMMRQKM DSPc X X -SYK Syk P43405 human Syk 6850 P43405 SYK human Y352 447660 tEVyEsPyADPEEIR X 2701; 2717; 14791; 73382; 82975; 31754 -SYK Syk P43405 human SNCA 6622 P37840 SNCA human Y125 448279 VDPDNEAyEMPsEEG Synuclein X X -SYK Syk P43405 human DOCK2 1794 Q92608 DOCK2 human Y224 1876205006 SsPTHsLyVFVRNFV DOCK_N X -SYK Syk P43405 human BLNK 29760 Q8WV28 BLNK human Y178 447716 LLEDEADyVVPVEDN X X -SYK Syk P43405 human Syk 20963 P48025 Syk mouse Y342 447659 LPMDTEVyESPyADP X -SYK Syk P43405 human FCGR2A 2212 P12318 FCGR2A human Y281 449554 LEEtNNDyEtADGGy X -SYK Syk P43405 human DOCK2 1794 Q92608 DOCK2 human Y122 1876205004 LQVQSMMyDLMEWRS DOCK_N X -SYK Syk P43405 human DOCK2 1794 Q92608 DOCK2 human Y985 1876205000 DLIGKNVyPGDWMAM X -SYK Syk P43405 human Btk 695 Q06187 BTK human Y551 447486 RYVLDDEytsSVGSk PK_Tyr_Ser-Thr X 69360; 18805; 64137; 16803 -SYK Syk P43405 human LAX1 54900 Q8IWV1 LAX1 human Y294 35546001 AFQCCRDyENVPAAD LAX X -SYK Syk P43405 human GCET2 257144 Q8N6F7 GCSAM human Y128 463674 LGGTEtEySLLHMPS HGAL X X -SYK Syk P43405 human Syk 6850 P43405 SYK human Y348 447659 LPMDtEVyEsPyADP X -SYK Syk P43405 human RIP140 268903 Q8CBD1 Nrip1 mouse Y436 25234801 sSGDESSySNCVPID NRIP1_repr_2 X X -SYK Syk P43405 human DBNL 13169 Q62418 Dbnl mouse Y350 450091 PPEQDTLyEEPPLVQ X -SYK Syk P43405 human CBL 867 P22681 CBL human Y774 448531 sENEDDGyDVPKPPV X 3555 -SYK Syk P43405 human DUSP3 1845 P51452 DUSP3 human Y38 459626 NEVTPRIyVGNASVA DSPc X X -SYK Syk P43405 human GCET2 257144 Q8N6F7 GCSAM human Y107 454098 GNsAEEyyENVPCkA HGAL X X -SYK Syk P43405 human CBL 867 P22681 CBL human Y731 448530 QQIDSCTyEAMyNIQ X 3554 -SYK Syk P43405 human BLNK 29760 Q8WV28 BLNK human Y72 447718 SDDFDSDyENPDEHS X X -SYK Syk P43405 human LAX1 54900 Q8IWV1 LAX1 human Y373 460158 SNEDSSDyENVLTAK LAX X -SYK Syk P43405 human Tau 4137 P10636 MAPT human Y18 454024 MEDHAGTyGLGDRKD X X -SYK Syk P43405 human GCET2 257144 Q8N6F7 GCSAM human Y80 449472 QDNVDQtysEELCyt HGAL X -SYK Syk P43405 human Syk 6850 P43405 SYK human Y525 447661 ALRADENyykAQtHG PK_Tyr_Ser-Thr X X 2711; 2710; 12967; 5514; 4349; 6485; 12081; 46994; 16859 -SYK Syk P43405 human SHP-2 5781 Q06124 PTPN11 human Y542 448492 sKRkGHEytNIKysL X 3751; 94740; 15543; 64117 -SYK Syk P43405 human RHBG 57127 Q9H310 RHBG human Y429 3647000 SPPDSQHyEDQVHWQ X -SYK Syk P43405 human Syk 25155 Q64725 Syk rat Y519 447661 ALRADENyyKAQTHG PK_Tyr_Ser-Thr X 2710; 12967; 5514; 4349; 6485; 12081; 46994; 16859 -SYK Syk P43405 human SLP76 3937 Q13094 LCP2 human Y113 448218 ssFEEDDyESPNDDQ X -SYK Syk P43405 human Syk 6850 P43405 SYK human Y526 447662 LRADENyykAQtHGK PK_Tyr_Ser-Thr X X 2711; 2710; 12967; 5514; 4349; 6485; 12081; 46994; 16859 -SYK Syk P43405 human Syk 20963 P48025 Syk mouse Y346 447660 TEVyESPyADPEEIR X 2701; 2717; 14791; 73382; 82975; 31754 -SYK Syk P43405 human BLNK 29760 Q8WV28 BLNK human Y189 447717 VEDNDENyIHPtESS X -SYK Syk P43405 human HS1 3059 P14317 HCLS1 human Y397 451636 EDEPEGDyEEVLEPE X X 4507; 8714; 13708; 11880 -SYK Syk P43405 human DOCK2 1794 Q92608 DOCK2 human Y1405 1876205002 VkNAPGQyIQCFTVQ DHR-2_Lobe_B X -SYK Syk P43405 human STAT1 6772 P42224 STAT1 human Y701 447754 DGPkGtGyIktELIs X 9174; 9167; 5375; 25685; 8062; 8183; 8009; 55603; 7649; 25809; 57216; 45118; 39205; 88845; 88211; 76285; 90145 -SYK Syk P43405 human PIP5K1B 8395 O14986 PIP5K1B human Y105 9471801 FGIKPDDyLYSICSE X -SYK Syk P43405 human SLP76 3937 Q13094 LCP2 human Y128 448219 DGEDDGDyEsPNEEE X -SYK Syk P43405 human STING 340061 Q86WV6 STING1 human Y240 1875847400 AGIKDRVysNSIyEL TMEM173 X -SYK Syk P43405 human LAX1 54900 Q8IWV1 LAX1 human Y193 35546000 SSEDSHDyVNVPTAE LAX X -STK39 STLK3 Q9UEW8 human NKCC2 6557 Q13621 SLC12A1 human T105 458228 LQtFGHNtMDAVPKI AA_permease_N X -STK39 STLK3 Q9UEW8 human SLC4A4 8671 Q9Y6R1 SLC4A4 human S65 4699735 ERIsENysDKsDIEN X -STK39 STLK3 Q9UEW8 human NKCC1 6558 P55011 SLC12A2 human T207 467236 YYDtHTNtyYLRtFG AA_permease_N X -STK39 STLK3 Q9UEW8 human NKCC1 6558 P55011 SLC12A2 human T203 467235 HQHYYYDtHTNtyYL AA_permease_N X -STK39 STLK3 Q9UEW8 human KCC3 9990 Q9UHW9 SLC12A6 human T1048 4770548 YQEKVHMtWTKDKYM SLC12 X -STK39 STLK3 Q9UEW8 human NKCC2 6557 Q13621 SLC12A1 human T95 4708938 AYDsHTNtYYLQtFG AA_permease_N X X -STK39 STLK3 Q9UEW8 human KCC3 9990 Q9UHW9 SLC12A6 human S96 10787161 IEDLSQNsITGEHSQ X X -STK39 STLK3 Q9UEW8 human NKCC2 6557 Q13621 SLC12A1 human T100 458227 TNtYYLQtFGHNtMD AA_permease_N X X -STK39 STLK3 Q9UEW8 human NKCC1 20496 P55012 Slc12a2 mouse T205 455545 TNtYYLRtFGHNtMD AA_permease_N X X -STK39 STLK3 Q9UEW8 human NCCT 6559 P55017 SLC12A3 human T60 469617 MRtFGYNtIDVVPtY AA_permease_N X -STK39 STLK3 Q9UEW8 human NCCT 6559 P55017 SLC12A3 human T46 2286406 SSHPSHLtHSStFCM AA_permease_N X -STK39 STLK3 Q9UEW8 human NCCT 6559 P55017 SLC12A3 human T55 469616 SStFCMRtFGYNtID AA_permease_N X -STK39 STLK3 Q9UEW8 human NKCC1 20496 P55012 Slc12a2 mouse T210 455546 LRtFGHNtMDAVPRI AA_permease_N X -STK39 STLK3 Q9UEW8 human Snail1 6615 O95863 SNAI1 human T203 21400402 QGHVRtHtGEkPFSC X -STK39 STLK3 Q9UEW8 human NKCC1 6558 P55011 SLC12A2 human T212 455545 TNtyYLRtFGHNtMD AA_permease_N X -HUNK HUNK P57058 human ITM2A 9452 O43736 ITM2A human T35 1869192400 TVRTQILtGkELRVA X X -Lyn LYN Q07014 rat FAK 25614 O35346 Ptk2 rat Y577 447890 yMEDstyyKAsKGKL PK_Tyr_Ser-Thr X 3281 -Lyn LYN Q07014 rat Syk 25155 Q64725 Syk rat Y346 447660 TEVyESPyADPEEIR X 2701; 2717; 14791; 73382; 82975; 31754 -Lyn LYN Q07014 rat GRP58 29468 P11598 Pdia3 rat Y467 453430 KKLTPKKyEGGRELN Thioredoxin X -Lyn LYN Q07014 rat GRP58 29468 P11598 Pdia3 rat Y454 453429 VkGFPTIyFsPANKK Thioredoxin X -Lyn LYN Q07014 rat CK2A1 1457 P68400 CSNK2A1 human Y255 450324 VLGTEDLyDyIDkYN Pkinase X -Lyn LYN Q07014 rat GRP58 29468 P11598 Pdia3 rat Y445 453428 ANDVPSPyEVkGFPT Thioredoxin X -Lyn LYN Q07014 rat HS1 3059 P14317 HCLS1 human Y222 452057 MEAPttAykkTTPIE X -Lyn LYN Q07014 rat FAK 25614 O35346 Ptk2 rat Y576 447889 RyMEDstyyKAsKGK PK_Tyr_Ser-Thr X 3281 -Myo3a MYO3A Q8K3H5 mouse MYO3A 667663 Q8K3H5 Myo3a mouse T184 29674700 sTRHRLNtSVGTPFW Pkinase X -Myo3a MYO3A Q8K3H5 mouse MYO3A 667663 Q8K3H5 Myo3a mouse S177 36841902 GVSAQLSsTRHRLNt Pkinase X -Myo3a MYO3A Q8K3H5 mouse MYO3A 667663 Q8K3H5 Myo3a mouse S332 36841903 KKGNLNRsLISSLKD X -Myo3a MYO3A Q8K3H5 mouse MYO3A 667663 Q8K3H5 Myo3a mouse S313 36841904 DIHQCLGsTEKARHE X -Prkci PKCI Q62074 mouse LLGL1 3996 Q15334 LLGL1 human S663 449917 LkKsLRQsFRRIRKs X X -Prkci PKCI Q62074 mouse Fe65 11785 Q9QXJ1 Apbb1 mouse S459 13309858 VWGVGRDsGSNRDFA PID X -Prkci PKCI Q62074 mouse RIC8A 101489 Q3TIR3 Ric8a mouse S501 3213318 VIQPMGMsPRGHLTS Ric8 X X -Prkci PKCI Q62074 mouse LLGL2 3993 Q6P1M3 LLGL2 human S653 13197200 LkKsLRQsFRRMRRS X -Cdk7 CDK7 Q03147 mouse POLR2A 20020 P08775 Polr2a mouse S1619 447616 SPSYsPtsPSYSPTS RNA_pol_Rpb1_R X 4735; 13523; 13546; 67221 -IRAK1 IRAK1 P51617 human PELI1 57162 Q96FA3 PELI1 human T80 7388010 DQHsIsYtLsRAQtV Pellino X -IRAK1 IRAK1 P51617 human IRAK1 3654 P51617 IRAK1 human T387 447721 RtQTVRGtLAYLPEE Pkinase X -IRAK1 IRAK1 P51617 human PELI1 57162 Q96FA3 PELI1 human S78 7388013 NKDQHsIsYtLsRAQ Pellino X -IRAK1 IRAK1 P51617 human PELI1 57162 Q96FA3 PELI1 human T86 7388011 YtLsRAQtVVVEYTH Pellino X -IRAK1 IRAK1 P51617 human PELI1 57162 Q96FA3 PELI1 human T288 7388016 QCPVGFNtLAFPsMk Pellino X -IRAK1 IRAK1 P51617 human PELI1 57162 Q96FA3 PELI1 human T127 7452903 GSQSNsDtQSVQSTI Pellino X -IRAK1 IRAK1 P51617 human PELI2 57161 Q9HAT8 PELI2 human T290 5860078 QCPVGLNtLAFPsIN Pellino X -IRAK1 IRAK1 P51617 human IRAK1 3654 P51617 IRAK1 human T209 450949 LCEISRGtHNFSEEL X -IRAK1 IRAK1 P51617 human PELI1 57162 Q96FA3 PELI1 human S293 7388014 FNtLAFPsMkRkDVV Pellino X -IRAK1 IRAK1 P51617 human PELI1 57162 Q96FA3 PELI1 human S125 18122803 VPGSQSNsDtQSVQS Pellino X -IRAK1 IRAK1 P51617 human STAT3 6774 P40763 STAT3 human S727 448191 NtIDLPMsPrTLDSL X 9134; 9136; 34911; 94994; 49081; 58978; 87544; 71958; 50804 -IRAK1 IRAK1 P51617 human PELI1 57162 Q96FA3 PELI1 human S76 7388015 IsNKDQHsIsYtLsR Pellino X -IRAK1 IRAK1 P51617 human USP20 74270 Q8C6M1 Usp20 mouse S334 7323248 RMKDRKFsWGQQRTN X X -IRAK1 IRAK1 P51617 human PELI1 57162 Q96FA3 PELI1 human S82 7388012 HsIsYtLsRAQtVVV Pellino X -IRAK1 IRAK1 P51617 human PELI1 57162 Q96FA3 PELI1 human S70 7452902 PQAAKAIsNKDQHsI Pellino X -CDKL5 CDKL5 O76039 human TNRC18 84629 O15417 TNRC18 human S660 50801529 RDPERPEsAkAFGRE X -CDKL5 CDKL5 O76039 human TTDN1 136647 Q8TAP9 MPLKIP human S40 6422892 GGGPrPPsPrDGyGs X -CDKL5 CDKL5 O76039 human LRRC4C 57689 Q9HCJ2 LRRC4C human S631 3893278 PLLIRMNsKDNVQET X X -CDKL5 CDKL5 O76039 human RP1 10982 Q15555 MAPRE2 human S223 476320 stPsRPssAkRASSS X -CDKL5 CDKL5 O76039 human PPP1R26 9858 Q5T8A7 PPP1R26 human T606 1875006602 GGHVRPStPKKMQEV PPP1R26_N X -CDKL5 CDKL5 O76039 human TCEB3 6924 Q14241 ELOA human S285 18914150 EENRRPPsGDNAREK X X -CDKL5 CDKL5 O76039 human hnRNP F 3185 P52597 HNRNPF human T215 23113704 GPyDrPGtArryIGI X -CDKL5 CDKL5 O76039 human ZC3H14 79882 Q6PJT7 ZC3H14 human T734 15503934 LkWIRPQtsE_____ X -CDKL5 CDKL5 O76039 human RPL13 6137 P26373 RPL13 human S52 27460376 RIAPRPAsGPIRPIV Ribosomal_L13e X -CDKL5 CDKL5 O76039 human CEP131 22994 Q9UPN4 CEP131 human S35 27444528 PVSRRPGsAATTkPI X X -CDKL5 CDKL5 O76039 human PHF23 79142 Q9BUL5 PHF23 human S400 25174009 RLGGPPKsGEP____ X -CDKL5 CDKL5 O76039 human ZNF192 7745 Q15776 ZKSCAN8 human S141 1875006800 DILGRPVsARVHGHR X -CDKL5 CDKL5 O76039 human ZAP3 56252 P49750 YLPM1 human S1089 18017826 GLVrPGssREKVPGG X -CDKL5 CDKL5 O76039 human VIRMA 25962 Q69YN4 VIRMA human S1759 30990559 LPPLRPLsSTGYRPs X -CDKL5 CDKL5 O76039 human CDKL5 6792 O76039 CDKL5 human Y171 454076 NNANytEyVATRWYR Pkinase X X -CDKL5 CDKL5 O76039 human ZAP3 56252 P49750 YLPM1 human S1088 31086542 rGLVrPGssREKVPG X -CDKL5 CDKL5 O76039 human RBMX 27316 P38159 RBMX human S261 18913016 DyPsrGysDrDGyGR X -CDKL5 CDKL5 O76039 human ZNF592 9640 Q92610 ZNF592 human S1100 22780931 NHLKRPVsGVGDAPG X -CDKL5 CDKL5 O76039 human amphiphysin 218038 Q7TQF7 Amph mouse S293 465542 PAPVRPRsPsQtRKG X -CDKL5 CDKL5 O76039 human BPY2-IP1 55201 Q66K74 MAP1S human S900 476391 DrAsRPLsARsEPsE X X -CDKL5 CDKL5 O76039 human CDKL5 6792 O76039 CDKL5 human T169 1868100 EGNNANytEyVATRW Pkinase X -CDKL5 CDKL5 O76039 human MAP1A 4130 P78559 MAP1A human S900 456391 GtIsPtssLEEDKGF X -CDKL5 CDKL5 O76039 human DLG5 9231 Q8TDM6 DLG5 human S1115 9411518 QKRRRPKsAPSFRPK X -CDKL5 CDKL5 O76039 human smoothelin 6525 P53814 SMTN human S139 27457326 LYSGRPNsGSREDSK X -CDKL5 CDKL5 O76039 human claspin 63967 Q9HAW4 CLSPN human S1246 1875006600 FEAIRPGsAQQVKTG X -CDKL5 CDKL5 O76039 human treacle 6949 Q13428 TCOF1 human S801 476275 PAAARAPsAKGtISA Treacle X -CDKL5 CDKL5 O76039 human p400 57634 Q96L91 EP400 human S729 10371268 sPVNRPssAtNkALs X X -Prkacb PKACB P68181 mouse NKX2-1 25628 P23441 Nkx2-1 rat T9 451108 SMSPKHTtPFsVSDI X X -Prkacb PKACB P68181 mouse TIAM2 24001 Q6ZPF3 Tiam2 mouse T749 15503728 DSTLRKRtLsLTQRG X -MAPK11 P38B Q15759 human p300 2033 Q09472 EP300 human S12 25126714 VVEPGPPsAkRPKLs X -MAPK11 P38B Q15759 human ATF-2 1386 P15336 ATF2 human T69 448224 sVIVADQtPtPtRFL X X 9225; 94125; 40749; 61584; 44167 -MAPK11 P38B Q15759 human ATF-2 1386 P15336 ATF2 human T71 448225 IVADQtPtPtRFLkN X X 9225; 9221; 5112; 94125; 13850; 40749; 15411; 24329; 61584; 27934; 92109; 20534; 35858 -MAPK11 P38B Q15759 human SOD2 6648 P04179 SOD2 human T79 62403300 ALAKGDVtAQIALQP Sod_Fe_N X X -MAPK11 P38B Q15759 human P38B 5600 Q15759 MAPK11 human T241 54390600 RIMEVVGtPsPEVLA Pkinase X -MAPK11 P38B Q15759 human PIAS2 83422 Q6AZ28 Pias2 rat S116 464654 IAPHsPSsPVASVLL X X -MAPK11 P38B Q15759 human SNX27 81609 Q96L92 SNX27 human S51 486072 VRIVksEsGYGFNVR PDZ X X -MAPK11 P38B Q15759 human EEF2K 29904 O00418 EEF2K human S396 450812 TFDsLPssPssAtPH X -MAPK11 P38B Q15759 human HSF1 3297 Q00613 HSF1 human S307 449046 EPPsPPQsPRVEEAs Vert_HS_TF X -MAPK11 P38B Q15759 human Raptor 57521 Q8N122 RPTOR human S771 13251700 SASSTLGsPENEEHI X X -MAPK11 P38B Q15759 human E2F1 1869 Q01094 E2F1 human T433 447871 DCDFGDLtPLDF___ X -MAPK11 P38B Q15759 human EGFR 1956 P00533 EGFR human S1039 3178884 tPLLSsLsAtsNNst X -MAPK11 P38B Q15759 human Raptor 57521 Q8N122 RPTOR human S863 453732 LtQsAPAsPtNkGVH X X -MAPK11 P38B Q15759 human MAPKAPK5 8550 Q8IW41 MAPKAPK5 human T182 450093 IDQGDLMtPQFtPyY Pkinase X -MAPK11 P38B Q15759 human P38B 5600 Q15759 MAPK11 human S261 54390601 HARTYIQsLPPMPQK Pkinase X -MAPK11 P38B Q15759 human NALP1 22861 Q9C000 NLRP1 human S107 1880261804 PSEPHLGsPSQPTST X -MAPK11 P38B Q15759 human CDC25B 994 P30305 CDC25B human S249 469600 kMEVEELsPLALGRF M-inducer_phosp X -MAPK11 P38B Q15759 human HSF1 3297 Q00613 HSF1 human S303 449045 RVkEEPPsPPQsPRV Vert_HS_TF X -MAPK11 P38B Q15759 human Tip60 iso2 10524 Q92993-2 KAT5 human T106 10800707 VEVVsPAtPVPSETA X -MAPK11 P38B Q15759 human HNF4 alpha 3172 P41235 HNF4A human S167 458371 VLSRQItsPVsGING X -MAPK11 P38B Q15759 human SOD2 6648 P04179 SOD2 human S106 7577901 SIFWTNLsPNGGGEP Sod_Fe_N X X -MAPK11 P38B Q15759 human EGFR 1956 P00533 EGFR human T1041 3178896 LLSsLsAtsNNstVA X -MAPK11 P38B Q15759 human ATF7 11016 P17544 ATF7 human T51 467515 sVIIADQtPtPtRFL X 94125; 40749; 61584; 44167 -MAPK11 P38B Q15759 human GYS1 2997 P13807 GYS1 human S727 457615 StPsEPLsPtssLGE X -MAPK11 P38B Q15759 human HSF1 3297 Q00613 HSF1 human S326 455484 ssVDtLLsPTALIDs Vert_HS_TF X -MAPK11 P38B Q15759 human TFEB 21425 Q9R210 Tfeb mouse S400 1880515602 LDFSHGLsFGGGGDE X -MAPK11 P38B Q15759 human GYS1 2997 P13807 GYS1 human T721 457616 AtsssLStPsEPLsP X -MAPK11 P38B Q15759 human PKCE 5581 Q02156 PRKCE human S350 486055 RsKsAPtsPCDQEIK X -MAPK11 P38B Q15759 human GYS1 2997 P13807 GYS1 human S653 448240 PsLsRHssPHQsEDE Glycogen_syn X -MAPK11 P38B Q15759 human GYS1 2997 P13807 GYS1 human S645 448238 RPAsVPPsPsLsRHs Glycogen_syn X -MAPK11 P38B Q15759 human SREBP-1 6720 P36956 SREBF1 human S63 23940711 AGGtDPAsPDTSSPG X -MAPK11 P38B Q15759 human E2F1 1869 Q01094 E2F1 human S403 447870 PEEFISLsPPHEALD X -MAPK11 P38B Q15759 human EWS 2130 Q01844 EWSR1 human T79 7359501 QPPTGYTtPTAPQAY X -MAPK11 P38B Q15759 human SREBP-1 6720 P36956 SREBF1 human T426 467200 TEVEDTLtPPPsDAG X -MAPK11 P38B Q15759 human CCND3 896 P30281 CCND3 human T283 452160 QGPsQtstPtDVtAI X 53966 -MAPK11 P38B Q15759 human Tip60 10524 Q92993 KAT5 human T158 10800707 VEVVsPAtPVPSETA X -MAPK11 P38B Q15759 human GR 2908 P04150 NR3C1 human S226 451796 IDENCLLsPLAGEDD GCR X 97285 -MAPK11 P38B Q15759 human STAT1 20846 P42225 Stat1 mouse S727 447753 tDNLLPMsPEEFDEM STAT1_TAZ2bind X X 9177; 8826; 62390 -MAPK11 P38B Q15759 human PIAS2 83422 Q6AZ28 Pias2 rat S113 464653 STSIAPHsPSsPVAS X X -MAPK11 P38B Q15759 human SMARCD3 66993 Q6P9Z1 Smarcd3 mouse T229 8097074 HLVEWHRtPTTQETD X -ERBB4 HER4 Q15303 human HER4 2066 Q15303 ERBB4 human Y1056 451500 GHsPPPAyTPMSGNQ X -ERBB4 HER4 Q15303 human HER4 2066 Q15303 ERBB4 human Y1162 2045347 RDKPKQEyLNPVEEN X -ERBB4 HER4 Q15303 human HER4 2066 Q15303 ERBB4 human Y1284 457470 IVAENPEyLSEFSLK X 4757 -RPS6KA6 RSK4 Q9UK32 human RSK4 27330 Q9UK32 RPS6KA6 human S232 457600 DQEKKAysFCGtVEy Pkinase X X -RPS6KA6 RSK4 Q9UK32 human p300 2033 Q09472 EP300 human S89 447592 SELLRSGsSPNLNMG X X -STYK1 STYK1 Q6J9G0 human beclin 1 8678 Q14457 BECN1 human S93 5473540 ARMMstEsANsFTLI X 14717 -STYK1 STYK1 Q6J9G0 human beclin 1 8678 Q14457 BECN1 human S90 472001 IPPARMMstEsANsF X 29362; 86455 -Tlk2 TLK2 O55047 mouse ASF1A 66403 Q9CQE6 Asf1a mouse S166 3245981 kLEDAEssNPNLQSL X -MAPK4 ERK4 P31152 human Akt1 207 P31749 AKT1 human T308 447856 kDGAtMKtFCGtPEy Pkinase X 5106; 2965; 9275; 4056; 5056; 13842; 13038; 43506; 48646; 86758; 80722; 77440; 80556 -PINK1 PINK1 Q9BXM7 human PARK2 50873 Q9WVS6 Prkn mouse S65 25538008 NCDLEQQsIVHIVQR ubiquitin X -PINK1 PINK1 Q9BXM7 human PARIS 155061 Q6NUN9 ZNF746 human S322 27533659 QATRFFPsPAQEGAW X -PINK1 PINK1 Q9BXM7 human PINK1 68943 Q99MQ3 Pink1 mouse S411 1883601200 VERGGNGsLMAPEVS Pkinase X -PINK1 PINK1 Q9BXM7 human LETM1 3954 O95202 LETM1 human T192 384464302 ILNGHsLtRRERRQF LETM1_RBD X -PINK1 PINK1 Q9BXM7 human MFN2 9927 O95140 MFN2 human S442 4746700 AEEIRRLsVLVDDYQ X -PINK1 PINK1 Q9BXM7 human PARK2 56816 Q9JK66 Prkn rat S65 25538008 NCDLEQQsIVHIVQR ubiquitin X -PINK1 PINK1 Q9BXM7 human PINK1 65018 Q9BXM7 PINK1 human S402 25792201 GLQLPFSsWYVDRGG Pkinase X X -PINK1 PINK1 Q9BXM7 human EFTU 7284 P49411 TUFM human S222 1871246005 ETPVIVGsALCALEG GTP_EFTU X X -PINK1 PINK1 Q9BXM7 human PINK1 65018 Q9BXM7 PINK1 human T257 25544600 AGEYGAVtYRKSkRG X X -PINK1 PINK1 Q9BXM7 human PINK1 65018 Q9BXM7 PINK1 human S228 25792200 MWNISAGsSSEAILN X X 89010; 46421 -PINK1 PINK1 Q9BXM7 human JUB 84962 Q96IF1 AJUBA human S39 18011036 GPGKGRLsGLGGPRK X -PINK1 PINK1 Q9BXM7 human FAM65B 193385 Q80U16 Ripor2 mouse S46 4746003 NGIIRsQsFAGFSGL PL48 X X -PINK1 PINK1 Q9BXM7 human ubiquitin P62991 UBA52-RPS27A-UBB-UBC mouse S65 9765472 DYNIQkEstLHLVLR ubiquitin X X 43163; 37642; 62802; 70973; 83816; 88503 -PINK1 PINK1 Q9BXM7 human ubiquitin P62988 UBA52-RPS27A-UBB-UBC human S65 9765472 DyNIQkEstLHLVLr ubiquitin X X 43163; 37642; 62802; 70973; 83816; 88503 -PINK1 PINK1 Q9BXM7 human MFN2 9927 O95140 MFN2 human T111 17402150 RTSNGKStVINAMLW Dynamin_N X -PINK1 PINK1 Q9BXM7 human MFN2 9927 O95140 MFN2 human S378 1877509600 AVRLIMDsLHMAARE X -PINK1 PINK1 Q9BXM7 human RHOT1 55288 Q8IXI2 RHOT1 human S156 21587701 AKNLkNIsELFyYAQ Ras X -PINK1 PINK1 Q9BXM7 human ubiquitin P62991 UBA52-RPS27A-UBB-UBC mouse T66 31728103 YNIQkEstLHLVLRL ubiquitin X -PINK1 PINK1 Q9BXM7 human Bcl-xL 598 Q07817 BCL2L1 human S62 449099 PSWHLADsPAVNGAT X -PINK1 PINK1 Q9BXM7 human PARK2 5071 O60260 PRKN human S65 25538008 NCDLDQQsIVHIVQR ubiquitin X X 36866 -PINK1 PINK1 Q9BXM7 human HIF3A iso2 53417 Q0VBL6-2 Hif3a mouse T12 57786401 LQRVRsNtELRKEKS X -PINK1 PINK1 Q9BXM7 human PARIS 155061 Q6NUN9 ZNF746 human S613 25759828 APPDPFKsPAsKGPL X -PINK1 PINK1 Q9BXM7 human EEF1A1 1915 P68104 EEF1A1 human S396 31884110 DGPkFLksGDAAIVD GTP_EFTU_D3 X X -PINK1 PINK1 Q9BXM7 human NEDD8 4738 Q15843 NEDD8 human S65 4705608 DykILGGsVLHLVLA ubiquitin X -PINK1 PINK1 Q9BXM7 human ubiquitin P62988 UBA52-RPS27A-UBB-UBC human T66 31728103 yNIQkEstLHLVLrL ubiquitin X -PINK1 PINK1 Q9BXM7 human UBA52 7311 P62987 UBA52 human S65 9765474 DyNIQkEstLHLVLr ubiquitin X X 43163; 37642; 62802; 70973; 83816; 88503 -EPHA5 EphA5 P54756 human GLO1 2739 Q04760 GLO1 human Y136 463450 GIAVPDVysACkRFE Glyoxalase X X -Cdk2 CDK2 Q63699 rat PKLR iso2 24651 P12928-2 Pklr rat S113 31084572 ATESFATsPLSYRPV PK X -Ret Ret G3V9H8 rat Ret 24716 G3V9H8 Ret rat Y1063 447625 TWIENKLyGMSDPNW X -Ret Ret G3V9H8 rat Ret 24716 G3V9H8 Ret rat Y1097 449891 RYANDSVyANWMVSP X -Ret Ret G3V9H8 rat Ret 24716 G3V9H8 Ret rat Y906 447627 DVYEEDSyVKKSKGR PK_Tyr_Ser-Thr X -Ret Ret G3V9H8 rat Ret 24716 G3V9H8 Ret rat Y1016 449894 MMVKSRDyLDLAAST X -Kdr VEGFR2 P35918 mouse VEGFR2 16542 P35918 Kdr mouse Y1212 447902 VCDPKFHyDNTAGIS X 2477 -Kdr VEGFR2 P35918 mouse VEGFR3 14257 P35917 Flt4 mouse Y1265 10799700 LPMTPTTyKASMDNQ X -Kdr VEGFR2 P35918 mouse VEGFR2 16542 P35918 Kdr mouse Y949 447903 RFRQGkDyVGELSVD PK_Tyr_Ser-Thr X 2476; 2471; 4991 -Kdr VEGFR2 P35918 mouse VEGFR3 14257 P35917 Flt4 mouse Y1230 4119675 CHSLAARyyNCVSFP X -Kdr VEGFR2 P35918 mouse VEGFR3 14257 P35917 Flt4 mouse Y1231 4119681 HSLAARyyNCVSFPG X -Kdr VEGFR2 P35918 mouse VEGFR2 16542 P35918 Kdr mouse Y1052 447899 FGLARDIykDPDyVR PK_Tyr_Ser-Thr X -Egfr EGFR Q9QX70 rat EGFR 24329 Q9QX70 Egfr rat Y1196 448060 PTAENAEyLRVAPPS X 4407; 47737 -Egfr EGFR Q9QX70 rat ERK2 5594 P28482 MAPK1 human T185 447593 HDHtGFLtEyVAtRW Pkinase X 9106; 4370; 4374; 9101; 4375; 4376; 4377; 3510; 5726; 88569; 13214; 13148; 70235; 9488; 89967; 8544; 14196; 14227; 14095; 14474; 75165; 98168; 33370; 54240; 15892; 45899; 55088; 9524; 69217; 48735 -Egfr EGFR Q9QX70 rat ERK1 5595 P27361 MAPK3 human T202 447542 HDHtGFLtEyVAtRW Pkinase X 9106; 4370; 4374; 9101; 4375; 4376; 4377; 3510; 5726; 88569; 13214; 13148; 70235; 9488; 89967; 8544; 14196; 14227; 14095; 14474; 75165; 98168; 33370; 54240; 15892; 45899; 55088; 9524; 69217; 48735 -Egfr EGFR Q9QX70 rat ERK2 5594 P28482 MAPK1 human Y187 447594 HtGFLtEyVAtRWyr Pkinase X 9106; 4370; 4374; 9101; 4375; 4376; 4377; 3510; 5726; 88569; 13214; 13148; 70235; 9488; 89967; 8544; 14196; 14227; 14095; 14474; 75165; 98168; 33370; 54240; 15892; 45899; 55088; 9524; 69217; 48735 -Egfr EGFR Q9QX70 rat ERK1 5595 P27361 MAPK3 human Y204 447543 HtGFLtEyVAtRWyr Pkinase X 9106; 4370; 4374; 9101; 4375; 4376; 4377; 3510; 5726; 88569; 13214; 13148; 70235; 9488; 89967; 8544; 14196; 14227; 14095; 14474; 75165; 98168; 33370; 54240; 15892; 45899; 55088; 9524; 69217; 48735 -RAF1 RAF1 P04049 human RAF1 5894 P04049 RAF1 human S621 447746 PKINRsAsEPsLHRA X X -RAF1 RAF1 P04049 human KLF10 7071 Q13118 KLF10 human T93 23119614 TIPAFCLtPPYsPSD X X -RAF1 RAF1 P04049 human BAD 572 Q92934 BAD human S75 447860 EIRsRHssyPAGtED Bcl-2_BAD X X 9291; 5284; 9296; 5193; 11865; 94223 -RAF1 RAF1 P04049 human ADCY6 25289 AAA40678 Adcy6 rat S746 467273 ALQRLsRsIVRsRVH X -RAF1 RAF1 P04049 human ADCY6 25289 AAA40678 Adcy6 rat S754 467275 IVRsRVHsTAVGVFS X -RAF1 RAF1 P04049 human BAD 572 Q92934 BAD human S118 447863 GRELRRMsDEFVDsF Bcl-2_BAD X X 9297 -RAF1 RAF1 P04049 human ADCY6 25289 AAA40678 Adcy6 rat S750 467274 LsRsIVRsRVHsTAV X -RAF1 RAF1 P04049 human MEK1 5604 Q02750 MAP2K1 human S222 448513 LIDsMANsFVGtRSY Pkinase X X 2338; 9121; 3958; 9154; 16211; 86128; 16780; 75262 -RAF1 RAF1 P04049 human TNNT2 24837 P50753 Tnnt2 rat T214 451556 RKsGKRQtEREKKKK Troponin X -RAF1 RAF1 P04049 human RAF1 5894 P04049 RAF1 human S359 28070702 StRIGsGsFGtVYkG PK_Tyr_Ser-Thr X -RAF1 RAF1 P04049 human BAD 12015 Q61337 Bad mouse S112 447860 ETRsRHssyPAGtEE Bcl-2_BAD X 9291; 5284; 9296; 5193; 11865; 94223 -RAF1 RAF1 P04049 human EEF1A2 1917 Q05639 EEF1A2 human S21 5434143 GHVDSGkstttGHLI GTP_EFTU X -RAF1 RAF1 P04049 human MEK1 5604 Q02750 MAP2K1 human S218 448514 VsGQLIDsMANsFVG Pkinase X X 9121; 3958; 9154; 86128 -RAF1 RAF1 P04049 human RAF1 5894 P04049 RAF1 human S259 447741 sQRQRststPNVHMV X 9421; 20011 -RAF1 RAF1 P04049 human Myc 4609 P01106 MYC human T23 448497 MPLNVsFtNRNyDLD Myc_N X -RAF1 RAF1 P04049 human RAF1 5894 P04049 RAF1 human S338 447742 RPRGQRDssyyWEIE X 9427 -RAF1 RAF1 P04049 human BAD 572 Q92934 BAD human S99 447862 PFrGrsRsAPPNLWA Bcl-2_BAD X 9295; 5286; 4366 -RAF1 RAF1 P04049 human ADCY6 25289 AAA40678 Adcy6 rat S744 467272 PNALQRLsRsIVRsR X -RAF1 RAF1 P04049 human MYPT1 4659 O14974 PPP1R12A human T696 448587 ARQsRRstQGVtLtD X 5163 -Rps6ka4 MSK2 Q9Z2B9 mouse H3 360198 P68433 H3c1 mouse S10 455676 tkQTARkstGGkAPr Histone X 9701; 9711; 9606; 3465; 3642; 3377; 3475; 3458; 5764; 47398; 8481; 8552; 53348; 29237; 66065; 43185; 64522; 52725 -NME1 NME1 P15531 human NME1 4830 P15531 NME1 human H118 474528 QVGRNIIhGsDsVEs NDK X X -NME1 NME1 P15531 human KSR 16706 Q61097 Ksr1 mouse S434 456128 LDSSSNPsSTTSSTP X X -NME1 NME1 P15531 human ACLY 24159 P16638 Acly rat H759 9643000 SSEVQFGhAGACANQ Ligase_CoA X -NME1 NME1 P15531 human NME1 4830 P15531 NME1 human S44 450096 GLkFMQAsEDLLkEH NDK X -NME1 NME1 P15531 human PGAM1 5223 P18669 PGAM1 human H11 27939200 YkLVLIRhGEsAWNL His_Phos_1 X -NME1 NME1 P15531 human NME1 4830 P15531 NME1 human S120 450098 GRNIIhGsDsVEsAE NDK X -NME1 NME1 P15531 human KSR 16706 Q61097 Ksr1 mouse S392 449297 ARLRRtEsVPsDINN X X 4951 -MYLK3 caMLCK Q32MK0 human PPP1R2 192361 P50411 Ppp1r2 rat S44 2231000 EEELSKKsQKWDEMN X -MYLK3 caMLCK Q32MK0 human MRLC3 10627 P19105 MYL12A human S19 7382102 KRPQRAtsNVFAMFD X -MYLK3 caMLCK Q32MK0 human MEF2C 4208 Q06413 MEF2C human T80 19083402 NEPHESRtNsDIVEt X -MYLK3 caMLCK Q32MK0 human MRLC2V 17906 P51667 Myl2 mouse S15 2846506 kRIEGGssNVFsMFE X -MYLK3 caMLCK Q32MK0 human TNNI3 7137 P19429 TNNI3 human S24 448424 APIRRRssNyRAyAt Troponin-I_N X 4004 -MYLK3 caMLCK Q32MK0 human MRLC3 10627 P19105 MYL12A human T18 7382101 KKRPQRAtsNVFAMF X -CDK11B CDK11B P21127 human AR 367 P10275 AR human S310 448413 TEDTAEysPFKGGYT Androgen_recep X X 61248 -CDK11B CDK11B P21127 human eIF3-epsilon 8665 O00303 EIF3F human S46 448818 PAAAPASsSDPAAAA X X -Gsk3b GSK3B Q9WV60 mouse NFkB-p105 4790 P19838 NFKB1 human S903 455617 KtTsQAHsLPLsPAs X X -Gsk3b GSK3B Q9WV60 mouse CRY2 12953 Q9R194 Cry2 mouse S553 456804 TGPRALSsGPAsPKR X X -Gsk3b GSK3B Q9WV60 mouse FTO 26383 Q8BGW1 Fto mouse S249 1115398000 YSYsCEGsEDEsEDE FTO_NTD X -Gsk3b GSK3B Q9WV60 mouse CCND1 12443 P25322 Ccnd1 mouse T286 447839 EEAGLACtPtDVRDV X X -Gsk3b GSK3B Q9WV60 mouse SOX11 20666 Q7M6Y2 Sox11 mouse S244 454322 SVAKVPAsPTLSSAA X -Gsk3b GSK3B Q9WV60 mouse C/EBP-beta 12608 P28033 Cebpb mouse T179 455887 GSsGsLStssSssPP X X -Gsk3b GSK3B Q9WV60 mouse CRMP-4 22240 Q62188 Dpysl3 mouse T509 454328 PVFDLtttPkGGtPA X -Gsk3b GSK3B Q9WV60 mouse MYO1C iso3 17913 Q9WTI7-3 Myo1c mouse S1020 34404301 DGIIDFTsGSELLIT Myosin_TH1 X X -Gsk3b GSK3B Q9WV60 mouse NRF2 18024 Q60795 Nfe2l2 mouse S335 18258505 MEFNDSDsGIsLNTs X X -Gsk3b GSK3B Q9WV60 mouse neurogenin 2 11924 P70447 Neurog2 mouse S231 2255101 SPYSCTLsPAsPGSD X -Gsk3b GSK3B Q9WV60 mouse Cbl-b 208650 Q3TTA7 Cblb mouse S480 4717392 RQNsPVtsPGssPLA X -Gsk3b GSK3B Q9WV60 mouse FTO 26383 Q8BGW1 Fto mouse S253 27449492 CEGsEDEsEDEsSFE FTO_NTD X -Gsk3b GSK3B Q9WV60 mouse CCND1 12443 P25322 Ccnd1 mouse T288 451435 AGLACtPtDVRDVDI X -Gsk3b GSK3B Q9WV60 mouse PLEKHO1 67220 Q9JIY0 Plekho1 mouse S341 12739074 KAKDPPQsPPDSESE X -Gsk3b GSK3B Q9WV60 mouse LPCAT1 210992 Q3TFD2 Lpcat1 mouse S178 17533100 RPVFVSRsDQDsRRK Acyltransferase X -Gsk3b GSK3B Q9WV60 mouse CTNNB1 12387 Q02248 Ctnnb1 mouse S37 447582 YLDsGIHsGATtTAP X X 9561; 2009; 4270; 13537; 41334; 60180 -Gsk3b GSK3B Q9WV60 mouse PTEN 19211 O08586 Pten mouse T366 449634 ASSSTSVtPDVsDNE X -Gsk3b GSK3B Q9WV60 mouse NRF2 18024 Q60795 Nfe2l2 mouse S355 18258504 PEHsVESsIYGDPPP X X -Gsk3b GSK3B Q9WV60 mouse NRF2 18024 Q60795 Nfe2l2 mouse S338 18258501 NDSDsGIsLNTsPSR X X -Gsk3b GSK3B Q9WV60 mouse VHL 22346 P40338 Vhl mouse S34 469116 PVLRSVNsREPSQVI VHL X -Gsk3b GSK3B Q9WV60 mouse MDM2 17246 P23804 Mdm2 mouse S240 454921 CLDQDsVsDQFsVEF X -Gsk3b GSK3B Q9WV60 mouse DHX33 216877 Q80VY9 Dhx33 mouse T482 1883375203 KDDQLTLtPIGRKMA X X -Gsk3b GSK3B Q9WV60 mouse CAP1 12331 P40124 Cap1 mouse S309 2525971 PKPQtsPsPKPAtKK X -Gsk3b GSK3B Q9WV60 mouse CTNNB1 12387 Q02248 Ctnnb1 mouse S45 447488 GATtTAPsLsGkGNP X 9565; 9564; 24710; 70034; 19807; 96727; 77605 -Gsk3b GSK3B Q9WV60 mouse CRMP-2 12934 O08553 Dpysl2 mouse T514 454386 sVtPktVtPAssAkt X 9397 -Gsk3b GSK3B Q9WV60 mouse MAP1B 17755 P14873 Map1b mouse T1265 455476 PPsPIEKtPLGERsV X -Gsk3b GSK3B Q9WV60 mouse NRF2 18024 Q60795 Nfe2l2 mouse S342 18258503 sGIsLNTsPSRAsPE X X -Gsk3b GSK3B Q9WV60 mouse MCL1 17210 P97287 Mcl1 mouse S140 460683 kSsGADGsLPStPPP X 4579 -Gsk3b GSK3B Q9WV60 mouse Tau 17762 P10637 Mapt mouse T497 447933 ssPGsPGtPGsRsRt X 25377; 43964; 53001; 49561; 20060; 33032; 30505; 20739; 98160 -Gsk3b GSK3B Q9WV60 mouse ULK1 22241 O70405 Ulk1 mouse S405 23070960 HGRTPsPsPTCSSSP X -Gsk3b GSK3B Q9WV60 mouse Myb 17863 P06876 Myb mouse T572 1308922 LTSSVLMtPVSEDED X -Gsk3b GSK3B Q9WV60 mouse Cbl-b 208650 Q3TTA7 Cblb mouse S476 3823372 KCTDRQNsPVtsPGs X -Gsk3b GSK3B Q9WV60 mouse neurogenin 2 11924 P70447 Neurog2 mouse S234 2255100 SCTLsPAsPGSDVDy X -Gsk3b GSK3B Q9WV60 mouse GSK3B 2932 P49841 GSK3B human Y216 448569 RGEPNVsyICsRyyR Pkinase X -Gsk3b GSK3B Q9WV60 mouse ULK1 22241 O70405 Ulk1 mouse S415 4958506 CSSSPSPsGRPGPFS X -Gsk3b GSK3B Q9WV60 mouse Tau 17762 P10637 Mapt mouse S494 447928 sGyssPGsPGtPGsR X 39357; 30505 -Gsk3b GSK3B Q9WV60 mouse MAP1B 17755 P14873 Map1b mouse S1260 454136 sLsPsPPsPIEKtPL X -Gsk3b GSK3B Q9WV60 mouse NRF2 18024 Q60795 Nfe2l2 mouse S347 18258502 NTsPSRAsPEHsVES X X -Gsk3b GSK3B Q9WV60 mouse SOX4 20677 Q06831 Sox4 mouse S316 41454646 GRSSAAssPAASRSP X -Gsk3b GSK3B Q9WV60 mouse PELP1 75273 Q9DBD5 Pelp1 mouse T751 453708 PVLAPsGtPPPsIPP X -Gsk3b GSK3B Q9WV60 mouse MDM2 17246 P23804 Mdm2 mouse S254 459215 FEVESLDsEDYsLSD X -Gsk3b GSK3B Q9WV60 mouse C/EBP-beta 12608 P28033 Cebpb mouse T188 447878 sSssPPGtPSPADAK X 3084 -Gsk3b GSK3B Q9WV60 mouse SOX4 20677 Q06831 Sox4 mouse S315 50800249 SGRSSAAssPAASRS X -Gsk3b GSK3B Q9WV60 mouse RCAN1 54720 Q9JHG6 Rcan1 mouse S165 456023 FLIsPPAsPPVGWKQ Calcipressin X -Gsk3b GSK3B Q9WV60 mouse CTNNB1 12387 Q02248 Ctnnb1 mouse S29 3075000 VsHWQQQsYLDsGIH X -Gsk3b GSK3B Q9WV60 mouse GSK3B 56637 Q9WV60 Gsk3b mouse Y216 448569 RGEPNVsyICsRYYR Pkinase X -Gsk3b GSK3B Q9WV60 mouse SIRT7 209011 Q8BKJ9 Sirt7 mouse T256 1874512902 PLNWEAAtEAAsKAD SIR2 X -Gsk3b GSK3B Q9WV60 mouse C/EBP-beta 12608 P28033 Cebpb mouse S184 455886 LStssSssPPGtPSP X X -Gsk3b GSK3B Q9WV60 mouse Tau 17762 P10637 Mapt mouse S491 447927 GERsGyssPGsPGtP X 29957 -Gsk3b GSK3B Q9WV60 mouse DZIP1 66573 Q8BMD2 Dzip1 mouse S520 40586900 KPSSTSPsPQELRTN X X -Gsk3b GSK3B Q9WV60 mouse Tau 17762 P10637 Mapt mouse S696 449082 PVVsGDtsPRHLsNV X 35834; 20194; 98523; 91600; 49562 -Gsk3b GSK3B Q9WV60 mouse LPCAT1 210992 Q3TFD2 Lpcat1 mouse S182 17533101 VSRsDQDsRRKTVEE Acyltransferase X -Gsk3b GSK3B Q9WV60 mouse Jun 16476 P05627 Jun mouse T242 450450 VPEMPGEtPPLsPID Jun X -Gsk3b GSK3B Q9WV60 mouse SOX11 20666 Q7M6Y2 Sox11 mouse S289 50800237 PPAPPALsPASSRCV X -Gsk3b GSK3B Q9WV60 mouse axin 1 12005 O35625 Axin1 mouse T480 451091 HVQRVMRtPGCQsPG Axin_b-cat_bind X X -Gsk3b GSK3B Q9WV60 mouse Jun 16476 P05627 Jun mouse S246 450451 PGEtPPLsPIDMESQ X 2994 -Gsk3b GSK3B Q9WV60 mouse CARM1 59035 Q9WVG6 Carm1 mouse T132 125971700 LKTCRGHtLERSVFS CARM1 X -Gsk3b GSK3B Q9WV60 mouse RCAN1 54720 Q9JHG6 Rcan1 mouse S161 456022 PDKQFLIsPPAsPPV Calcipressin X -Gsk3b GSK3B Q9WV60 mouse Myc 17869 P01108 Myc mouse T73 448496 KKFELLPtPPLsPsR Myc_N X 46650 -Gsk3b GSK3B Q9WV60 mouse CCND3 12445 P30282 Ccnd3 mouse T283 452160 QGPSQTStPTDVTAI X X 53966 -Gsk3b GSK3B Q9WV60 mouse CRY2 12953 Q9R194 Cry2 mouse S557 456803 ALSsGPAsPKRKLEA X -Gsk3b GSK3B Q9WV60 mouse NFkB-p105 4790 P19838 NFKB1 human S907 451565 QAHsLPLsPAstRQQ X X -Gsk3b GSK3B Q9WV60 mouse Tau 17762 P10637 Mapt mouse S554 447930 NVRSkIGstENLKHQ Tubulin-binding X -Gsk3b GSK3B Q9WV60 mouse CTNNB1 12387 Q02248 Ctnnb1 mouse T120 6406005 QFDAAHPtNVQRLAE X -Gsk3b GSK3B Q9WV60 mouse CTNNB1 12387 Q02248 Ctnnb1 mouse T41 447583 GIHsGATtTAPsLsG X 9561; 9565; 4270; 13537; 41334; 60180 -Gsk3b GSK3B Q9WV60 mouse Tau 17762 P10637 Mapt mouse S688 449081 GAEIVyKsPVVsGDt X 9632 -Gsk3b GSK3B Q9WV60 mouse Kv4.2 16508 Q9Z0V2 Kcnd2 mouse S616 457613 EGDDRPEsPEYsGGN X -Gsk3b GSK3B Q9WV60 mouse NRF2 18024 Q60795 Nfe2l2 mouse S351 18258500 SRAsPEHsVESsIYG X X -Gsk3b GSK3B Q9WV60 mouse IL1RL1 17082 P14719 Il1rl1 mouse S442 25585004 AATVVESsIQNsRRQ TIR X -Gsk3b GSK3B Q9WV60 mouse gephyrin 268566 Q8BUV3 Gphn mouse S270 2020113 LsttPsEsPRAQATs X -Gsk3b GSK3B Q9WV60 mouse axin 1 12005 O35625 Axin1 mouse S485 451092 MRtPGCQsPGPGHRs Axin_b-cat_bind X X -Gsk3b GSK3B Q9WV60 mouse CRMP-2 12934 O08553 Dpysl2 mouse T509 448083 PVCEVsVtPktVtPA X -Gsk3b GSK3B Q9WV60 mouse SIRT7 209011 Q8BKJ9 Sirt7 mouse S260 1874512904 EAAtEAAsKADtILC SIR2 X -Gsk3b GSK3B Q9WV60 mouse CTNNB1 12387 Q02248 Ctnnb1 mouse S33 447487 QQQsYLDsGIHsGAT X X 9561; 2009; 4270; 13537; 41334; 60180 -Tyk2 Tyk2 Q9R117 mouse IL13R 16164 O09030 Il13ra1 mouse Y402 450931 HWKKYDIyEKQSKEE X X -MAPK1 ERK2 Q8UWG6 chicken CRY2 12953 Q9R194 Cry2 mouse S265 453402 NANSLLAsPTGLSPY X X -MAPK1 ERK2 Q8UWG6 chicken CRY1 12952 P97784 Cry1 mouse S247 453401 NANSLLAsPtGLSPY X X -MAPK1 ERK2 Q8UWG6 chicken IRX2 373975 Q9PU52 IRX2 chicken S65 452192 AAATGFTsPLQYSTD X -MAPK1 ERK2 Q8UWG6 chicken IRX2 373975 Q9PU52 IRX2 chicken S46 452191 SSSGSAFsPYPGSAA X -MAPKAPK2 MAPKAPK2 P49137 human TAB3 257397 Q8N5C8 TAB3 human S506 1295507 HKYQRsSsSGSDDyA X -MAPKAPK2 MAPKAPK2 P49137 human Vimentin 280955 P48616 VIM cow T51 449416 LRPTTSRtLYTSsPG Filament_head X -MAPKAPK2 MAPKAPK2 P49137 human SMAD2 Q1W668 SMAD2 cow S255 448796 ELsPTTLsPVNHSLD X -MAPKAPK2 MAPKAPK2 P49137 human CDC25B 994 P30305 CDC25B human S169 455885 VLRNItNsQAPDGRR M-inducer_phosp X -MAPKAPK2 MAPKAPK2 P49137 human RSK2 110651 P18654 Rps6ka3 mouse S227 448063 DHEKKAysFCGtVEy Pkinase X 3556 -MAPKAPK2 MAPKAPK2 P49137 human Oct4 5460 Q01860 POU5F1 human S93 25236708 PQGGLEtsQPEGEAG X -MAPKAPK2 MAPKAPK2 P49137 human hnRNP A0 10949 Q13151 HNRNPA0 human S84 449874 VELkRAVsREDsARP X -MAPKAPK2 MAPKAPK2 P49137 human HSP27 15507 P14602 Hspb1 mouse S86 448403 RALNRQLssGVsEIR X 2406; 2401; 9709; 11892; 64293 -MAPKAPK2 MAPKAPK2 P49137 human GJA1 2697 P17302 GJA1 human S255 448852 HAtsGALsPAkDCGs X -MAPKAPK2 MAPKAPK2 P49137 human HSP27 3315 P04792 HSPB1 human S78 448402 PAysRALsRQLssGV X X 2405 -MAPKAPK2 MAPKAPK2 P49137 human LIMK1 3984 P53667 LIMK1 human S323 459630 KDLGrSEsLRVVCRP X X -MAPKAPK2 MAPKAPK2 P49137 human WNK4 65266 Q96J92 WNK4 human S575 53332700 PFLFRHAsYSSTTSD X -MAPKAPK2 MAPKAPK2 P49137 human CREB 1385 P16220 CREB1 human S119 448228 EILsRRPsyRkILND pKID X X 9187; 9196; 9198; 4095; 14228; 14001; 39561; 80120; 44864; 54960; 95995 -MAPKAPK2 MAPKAPK2 P49137 human CapZIP 92241 Q6JBY9 RCSD1 human S179 456201 RRFRRsQsDCGELGD CAP-ZIP_m X -MAPKAPK2 MAPKAPK2 P49137 human RBM7 67010 Q9CQT2 Rbm7 mouse S136 453069 QMVQRSFssPEDYQR X -MAPKAPK2 MAPKAPK2 P49137 human MKL1 57591 Q969V6 MRTFA human S333 3208578 CGLARQNstsLtGKP X X -MAPKAPK2 MAPKAPK2 P49137 human 14-3-3 zeta 7534 P63104 YWHAZ human S58 449833 VVGARRssWRVVssI 14-3-3 X 52631 -MAPKAPK2 MAPKAPK2 P49137 human TTP 22695 P22893 Zfp36 mouse S52 451150 RLTGRSTsLVEGRsC X -MAPKAPK2 MAPKAPK2 P49137 human TFCP2L1 81879 Q3UNW5 Tfcp2l1 mouse S393 1875342302 LPQKQDDsGDNsLCV X -MAPKAPK2 MAPKAPK2 P49137 human AGO2 27161 Q9UKV8 AGO2 human S387 472450 SkLMRsAsFNtDPyV ArgoL2 X X -MAPKAPK2 MAPKAPK2 P49137 human mGluR5 108071 Q3UVX5 Grm5 mouse S1158 25581600 LVALtPPsPFRDSVD GluR_Homer-bdg X -MAPKAPK2 MAPKAPK2 P49137 human BAG2 9532 O95816 BAG2 human S20 452167 GRFCRSSsMADRSSR X X -MAPKAPK2 MAPKAPK2 P49137 human Oct4 5460 Q01860 POU5F1 human S111 25236703 EsNsDGAsPEPCtVt X X -MAPKAPK2 MAPKAPK2 P49137 human Vimentin 280955 P48616 VIM cow S56 451514 SRtLYTSsPGGVYAT Filament_head X -MAPKAPK2 MAPKAPK2 P49137 human MDM2 4193 Q00987 MDM2 human S157 455457 SHLVSRPstSsRRRA X -MAPKAPK2 MAPKAPK2 P49137 human RBM7 10179 Q9Y580 RBM7 human S204 4033285 QrkVrMNsyPYLADr X X -MAPKAPK2 MAPKAPK2 P49137 human RIPK1 19766 Q60855 Ripk1 mouse S336 209632700 LPPsRsNsEQPGSLH X -MAPKAPK2 MAPKAPK2 P49137 human MDM2 4193 Q00987 MDM2 human S166 448130 SsRRRAIsEtEENsD X 3521 -MAPKAPK2 MAPKAPK2 P49137 human EEF2K 29904 O00418 EEF2K human S377 450811 PPLLRPLsENsGDEN X -MAPKAPK2 MAPKAPK2 P49137 human TTP 22695 P22893 Zfp36 mouse S178 451151 HVLRQsIsFsGLPsG X -MAPKAPK2 MAPKAPK2 P49137 human TH iso4 7054 P07101-4 TH human S44 448545 RFIGRRQsLIEDARK TOH_N X 2791 -MAPKAPK2 MAPKAPK2 P49137 human K18 3875 P05783 KRT18 human S53 447734 IsVsrstsFrGGMGs X -MAPKAPK2 MAPKAPK2 P49137 human RDBP 7936 P18615 NELFE human S51 454289 GGVkRsLsEQPVMDt X -MAPKAPK2 MAPKAPK2 P49137 human RBM7 10179 Q9Y580 RBM7 human S136 453069 QIIQRsFssPENFQr X X -MAPKAPK2 MAPKAPK2 P49137 human MAPKAPK2 9261 P49137 MAPKAPK2 human T338 448274 VPQtPLHtsRVLKED X -MAPKAPK2 MAPKAPK2 P49137 human MKL1 223701 Q8K4J6 Mrtfa mouse S371 3208578 SGLARQssTALAAKP X -MAPKAPK2 MAPKAPK2 P49137 human BRF1 677 Q07352 ZFP36L1 human S92 470147 RFRDRsFsEGGERLL Tis11B_N X X -MAPKAPK2 MAPKAPK2 P49137 human Nogo iso2 57142 Q9NQC3-2 RTN4 human S107 457468 VAPERQPsWDPSPVS X X -MAPKAPK2 MAPKAPK2 P49137 human PLK1 5347 P53350 PLK1 human S326 5393500 LTIPPRFsIAPssLD X X -MAPKAPK2 MAPKAPK2 P49137 human CEP131 22994 Q9UPN4 CEP131 human S47 3216078 kPIVRsVsVVTGsEQ X -MAPKAPK2 MAPKAPK2 P49137 human CapZIP 92241 Q6JBY9 RCSD1 human S244 456202 PPLRRsPsRTEKQEE RCSD X -MAPKAPK2 MAPKAPK2 P49137 human K20 66809 Q9D312 Krt20 mouse S13 463823 QSFHRsLsSSsQGPA X -MAPKAPK2 MAPKAPK2 P49137 human Akt1 207 P31749 AKT1 human S473 447855 RPHFPQFsysAsGtA Pkinase_C X 9271; 3787; 4060; 4051; 5102; 4058; 2336; 2337; 4075; 4070; 5012; 4071; 92982; 5315; 9563; 9018; 12694; 52240; 11962; 15116; 88106; 26580; 68035; 31957; 23430; 20235 -MAPKAPK2 MAPKAPK2 P49137 human ARPC5 10092 O15511 ARPC5 human S77 3309801 AVKDrAGsIVLKVLI P16-Arc X -MAPKAPK2 MAPKAPK2 P49137 human HSP27 15507 P14602 Hspb1 mouse S15 448401 FsLLrsPsWEPFRDW X -MAPKAPK2 MAPKAPK2 P49137 human p53 7157 P04637 TP53 human S20 447529 PLsQEtFsDLWkLLP P53_TAD X 9287 -MAPKAPK2 MAPKAPK2 P49137 human TRIM29 23650 Q14134 TRIM29 human S550 31836501 GyPsLMRsQsPkAQP X -MAPKAPK2 MAPKAPK2 P49137 human HSPA1L 3305 P34931 HSPA1L human S241 1869383201 DFDNRLVsHFVEEFK HSP70 X -MAPKAPK2 MAPKAPK2 P49137 human RSK2 6197 P51812 RPS6KA3 human S386 448065 HQLFRGFsFVAItsD Pkinase_C X X 9341; 9335; 13575; 11989; 12032; 75266; 93317; 13397; 13588 -MAPKAPK2 MAPKAPK2 P49137 human CDC25B 994 P30305 CDC25B human S323 448409 QRLFRsPsMPCsVIR M-inducer_phosp X -MAPKAPK2 MAPKAPK2 P49137 human BRF1 677 Q07352 ZFP36L1 human S203 470146 PRLQHsFsFAGFPSA X X -MAPKAPK2 MAPKAPK2 P49137 human TH iso3 7054 P07101-3 TH human S19 448542 KGFRRAVsELDAKQA TOH_N X -MAPKAPK2 MAPKAPK2 P49137 human PLK1 5347 P53350 PLK1 human S383 5393501 DMLQQLHsVNAskPS X -MAPKAPK2 MAPKAPK2 P49137 human TFCP2L1 81879 Q3UNW5 Tfcp2l1 mouse S397 1875342304 QDDsGDNsLCVyHAI X -MAPKAPK2 MAPKAPK2 P49137 human Vimentin 280955 P48616 VIM cow S83 451816 GVRLLQDsVDFSLAD Filament_head X -MAPKAPK2 MAPKAPK2 P49137 human PARN 5073 O95453 PARN human S557 483559 NHyYRNNsFTAPsTV X X -MAPKAPK2 MAPKAPK2 P49137 human PDE4A 25638 P54748 Pde4a rat S147 3189445 sFLYRSDsDYDMsPK X X -MAPKAPK2 MAPKAPK2 P49137 human MKL1 223701 Q8K4J6 Mrtfa mouse S351 10989194 PTPSRsLstsSsPsS X -MAPKAPK2 MAPKAPK2 P49137 human DDX5 1655 P17844 DDX5 human S198 27807802 CRACRLkstCIyGGA DEAD X X -MAPKAPK2 MAPKAPK2 P49137 human TH iso2 7054 P07101-2 TH human S19 448542 KGFRRAVsELDAKQA TOH_N X -MAPKAPK2 MAPKAPK2 P49137 human TH iso2 7054 P07101-2 TH human S67 448545 RFIGRRQsLIEDARK TOH_N X 2791 -MAPKAPK2 MAPKAPK2 P49137 human p90RSK 6195 Q15418 RPS6KA1 human S380 447990 HQLFRGFsFVAtGLM Pkinase_C X X 9341; 9335; 13575; 11989; 12032; 75266; 93317; 13397; 13588 -MAPKAPK2 MAPKAPK2 P49137 human GJA1 2697 P17302 GJA1 human S279 448853 sSPtAPLsPMsPPGy X -MAPKAPK2 MAPKAPK2 P49137 human CEP131 22994 Q9UPN4 CEP131 human S78 1211822 NNLRRsNsttQVSQP X -MAPKAPK2 MAPKAPK2 P49137 human DAZL 1618 Q92904 DAZL human S65 31908003 SFFARYGsVkEVKII RRM_1 X -MAPKAPK2 MAPKAPK2 P49137 human RIPK1 8737 Q13546 RIPK1 human S320 468644 AVVkRMQsLQLdCVA X X 58274; 39341 -MAPKAPK2 MAPKAPK2 P49137 human AYTL1 270084 Q8BYI6 Lpcat2 mouse S34 15146101 PMVPRQAsFFPPPVP X -MAPKAPK2 MAPKAPK2 P49137 human BRF1 677 Q07352 ZFP36L1 human S54 2475300 GGFPRRHsVtLPSSk Tis11B_N X X -MAPKAPK2 MAPKAPK2 P49137 human RDBP 7936 P18615 NELFE human S251 468611 GPFRRsDsFPERRAP X -MAPKAPK2 MAPKAPK2 P49137 human COPS5 10987 Q92905 COPS5 human S177 1874115102 IDPTRTIsAGkVNLG X X -MAPKAPK2 MAPKAPK2 P49137 human HIF3A iso2 53417 Q0VBL6-2 Hif3a mouse S184 291887100 HFSLRMKsTLtSRGR X -MAPKAPK2 MAPKAPK2 P49137 human TH iso4 7054 P07101-4 TH human S19 448542 KGFRRAVsELDAKQA TOH_N X -MAPKAPK2 MAPKAPK2 P49137 human SRF 6722 P11831 SRF human S103 447692 RGLKRsLsEMEIGMV X X 4261 -MAPKAPK2 MAPKAPK2 P49137 human TIF1B 10155 Q13263 TRIM28 human S473 452391 sGVkRsRsGEGEVsG X X -MAPKAPK2 MAPKAPK2 P49137 human GJA1 2697 P17302 GJA1 human S282 448854 tAPLsPMsPPGykLV X -MAPKAPK2 MAPKAPK2 P49137 human TH 7054 P07101 TH human S71 448545 RFIGRRQsLIEDARK TOH_N X 2791 -MAPKAPK2 MAPKAPK2 P49137 human RDBP 7936 P18615 NELFE human S115 452641 QPFQRsIsADDDLQE X -MAPKAPK2 MAPKAPK2 P49137 human CREB iso1 81646 P15337-1 Creb1 rat S133 448228 EILsRRPsYRkILND pKID X 9187; 9196; 9198; 4095; 14228; 14001; 39561; 80120; 44864; 54960; 95995 -MAPKAPK2 MAPKAPK2 P49137 human LSP1 16985 P19973 Lsp1 mouse S195 4704192 KLADRTEsLNRsIKK Caldesmon X -MAPKAPK2 MAPKAPK2 P49137 human LSP1 4046 P33241 LSP1 human S252 479435 PKLARQAsIELPsMA Caldesmon X -MAPKAPK2 MAPKAPK2 P49137 human PDE4D iso6 5144 Q08499-6 PDE4D human S133 483644 sFLYRSDsDYDLSPk X -MAPKAPK2 MAPKAPK2 P49137 human PIAS1 8554 O75925 PIAS1 human S522 3177709 DTSYINTsLIQDYRH X X -MAPKAPK2 MAPKAPK2 P49137 human TH iso3 7054 P07101-3 TH human S404 10348000 GELLHCLsEEPEIRA Biopterin_H X -MAPKAPK2 MAPKAPK2 P49137 human 5-LO 240 P09917 ALOX5 human S272 450169 CsLERQLsLEQEVQQ Lipoxygenase X 3748 -MAPKAPK2 MAPKAPK2 P49137 human MKL1 57591 Q969V6 MRTFA human S312 10989194 tPPVRsLstTNSsSS X X -MAPKAPK2 MAPKAPK2 P49137 human SMAD2 Q1W668 SMAD2 cow S250 448795 TGsPAELsPTTLsPV X -MAPKAPK2 MAPKAPK2 P49137 human AATF 26574 Q9NY61 AATF human T366 27136800 FTVYRNRtLQkWHDK AATF-Che1 X X -MAPKAPK2 MAPKAPK2 P49137 human HSP27 3315 P04792 HSPB1 human S15 448401 FsLLrGPsWDPFrDW X X 2404 -MAPKAPK2 MAPKAPK2 P49137 human CDC25B 994 P30305 CDC25B human S375 455380 ARVLRsksLCHDEIE M-inducer_phosp X -MAPKAPK2 MAPKAPK2 P49137 human TRIM29 23650 Q14134 TRIM29 human S552 27457998 PsLMRsQsPkAQPQT X -MAPKAPK2 MAPKAPK2 P49137 human HSF1 3297 Q00613 HSF1 human S121 455480 NIkRkVtsVSTLksE X -MAPKAPK2 MAPKAPK2 P49137 human Bcl-xL 598 Q07817 BCL2L1 human S62 449099 PSWHLADsPAVNGAT X -MAPKAPK2 MAPKAPK2 P49137 human PFKFB3 5209 Q16875 PFKFB3 human S461 448801 NPLMRRNsVtPLAsP X X -MAPKAPK2 MAPKAPK2 P49137 human TSC2 7249 P49815 TSC2 human S1254 448807 TALyksLsVPAASTA X X 3616 -MAPKAPK2 MAPKAPK2 P49137 human PDE4D iso6 24627 P14270-6 Pde4d rat S67 483644 SFLYRSDsDYDLSPK X -MAPKAPK2 MAPKAPK2 P49137 human TH 7054 P07101 TH human S19 448542 KGFRRAVsELDAKQA TOH_N X -MAPKAPK2 MAPKAPK2 P49137 human LSP1 16985 P19973 Lsp1 mouse S243 479435 PKLsRQPsIELPsMA Caldesmon X -MAPKAPK2 MAPKAPK2 P49137 human RSK2 110651 P18654 Rps6ka3 mouse S386 448065 HQLFRGFsFVAITSD Pkinase_C X 9341; 9335; 13575; 11989; 12032; 75266; 93317; 13397; 13588 -MAPKAPK2 MAPKAPK2 P49137 human CDC25C 995 P30307 CDC25C human S216 448418 sGLyRsPsMPENLNR M-inducer_phosp X 9528; 4901; 30790 -MAPKAPK2 MAPKAPK2 P49137 human Vimentin 280955 P48616 VIM cow S39 451766 TTSTRTYsLGSALRP Filament_head X -MAPKAPK2 MAPKAPK2 P49137 human p47phox 17969 Q09014 Ncf1 mouse S329 449404 QDtYRRNsVRFLQQR NECFESHC X X -MAPKAPK2 MAPKAPK2 P49137 human CREB 12912 Q01147 Creb1 mouse S119 448228 EILsRRPsyRkILND pKID X 9187; 9196; 9198; 4095; 14228; 14001; 39561; 80120; 44864; 54960; 95995 -MAPKAPK2 MAPKAPK2 P49137 human TH iso3 7054 P07101-3 TH human S40 448545 RFIGRRQsLIEDARK TOH_N X 2791 -MAPKAPK2 MAPKAPK2 P49137 human beclin 1 8678 Q14457 BECN1 human S90 472001 IPPARMMstEsANsF X X 29362; 86455 -MAPKAPK2 MAPKAPK2 P49137 human K20 54474 P35900 KRT20 human S13 463823 RSFHRsLsSSLQAPV X 39359 -MAPKAPK2 MAPKAPK2 P49137 human HSP27 3315 P04792 HSPB1 human S82 448403 RALsRQLssGVsEIr X X 2406; 2401; 9709; 11892; 64293 -MAPKAPK2 MAPKAPK2 P49137 human RIPK1 19766 Q60855 Ripk1 mouse S321 468644 PVLQRMFsLQHDCVP X X 83613; 38662 -MAPKAPK2 MAPKAPK2 P49137 human CDC25B 994 P30305 CDC25B human S353 452008 VQNkRRRsVtPPEEQ M-inducer_phosp X -Grk6 GRK6 O70293 mouse KOR-1 18387 P33534 Oprk1 mouse S369 449609 NtVQDPAsMRDVGGM X -Grk6 GRK6 O70293 mouse KOR-1 18387 P33534 Oprk1 mouse T357 52467201 MRMERQstNRVRNtV X -Grk6 GRK6 O70293 mouse KOR-1 18387 P33534 Oprk1 mouse S356 52467200 KMRMERQstNRVRNt X -Grk6 GRK6 O70293 mouse CXCR4 7852 P61073 CXCR4 human S339 458320 GkrGGHssVstEsEs X 59028 -Grk6 GRK6 O70293 mouse CXCR4 7852 P61073 CXCR4 human S330 12575202 GssLkILskGkrGGH X -Grk6 GRK6 O70293 mouse KOR-1 18387 P33534 Oprk1 mouse T363 52467202 stNRVRNtVQDPAsM X -Map3k1 MEKK1 Q62925 rat MEK1 26395 P31938 Map2k1 mouse T292 448287 EtPPRPRtPGRPLsS Pkinase X 26975 -MARK3 MARK3 iso3 P27448-3 human MARK3 iso3 4140 P27448-3 MARK3 human S601 470100 SQTRsRGstNLFsKL X -MARK3 MARK3 iso3 P27448-3 human MARK3 iso3 4140 P27448-3 MARK3 human S598 3597302 TPLSQTRsRGstNLF X -MARK3 MARK3 iso3 P27448-3 human MARK3 iso3 4140 P27448-3 MARK3 human S606 3597306 RGstNLFsKLTSKLT X -MARK3 MARK3 iso3 P27448-3 human MARK3 iso3 4140 P27448-3 MARK3 human T602 3597301 QTRsRGstNLFsKLT X -CSNK1G2 CK1G2 P78368 human COL4A3BP 10087 Q9Y5P4 CERT1 human S132 483985 ssLRRHGsMVsLVsG X X -CSNK1G2 CK1G2 P78368 human SNCA 6622 P37840 SNCA human T64 1876998407 EktkEQVtNVGGAVV Synuclein X -CSNK1G2 CK1G2 P78368 human beclin 1 8678 Q14457 BECN1 human S409 41159603 kIEDtGGsGGSYSIK APG6 X X -CSNK1G2 CK1G2 P78368 human SNCA 20617 O55042 Snca mouse T64 1876998407 EKtKEQVtNVGGAVV Synuclein X -CSNK1G2 CK1G2 P78368 human SMAD3 4088 P84022 SMAD3 human S418 6845003 LtQMGsPsIRCssVs X X -CSNK1G2 CK1G2 P78368 human LYN 4067 P07948 LYN human S13 1983291 SKGkDsLsDDGVDLk X -CSNK1G2 CK1G2 P78368 human beclin 1 8678 Q14457 BECN1 human T406 41159604 EKGkIEDtGGsGGSY APG6 X -CSNK1G2 CK1G2 P78368 human IRS4 8471 O14654 IRS4 human S859 36276295 KDAAsKPsGEGsFsK X X -Akt2 Akt2 Q60823 mouse GAB2 14389 Q9Z1S8 Gab2 mouse T388 448383 ATIPRRNtLPAMDNS X -Akt2 Akt2 Q60823 mouse QIK 235344 Q8CFH6 Sik2 mouse S358 487501 DGRQRRPstIAEQTV X -Akt2 Akt2 Q60823 mouse SGTA 6449 O43765 SGTA human S305 479908 QIRsRtPsAsNDDQQ X 8664 -Akt2 Akt2 Q60823 mouse SOX9 20682 Q04887 Sox9 mouse S181 456981 YQPrrrKsVKNGQAE X X -Akt2 Akt2 Q60823 mouse PGC-1 alpha 19017 O70343 Ppargc1a mouse S570 2045307 RMRSRsRsFsRHRSC X -Akt2 Akt2 Q60823 mouse STXBP4 20913 Q9WV89 Stxbp4 mouse S99 455472 RAKLRSEsPWEIAFI X X -Akt2 Akt2 Q60823 mouse MYO5A 17918 Q99104 Myo5a mouse S1650 480053 GLRKRtssIADEGty X -Akt2 Akt2 Q60823 mouse PITX2 18741 P97474 Pitx2 mouse T90 25790902 KRQRRQRtHFTSQQL Homeodomain X -Akt2 Akt2 Q60823 mouse GAB2 14389 Q9Z1S8 Gab2 mouse S211 4825112 TENARSAsFSQGTRQ X -PRKCQ PKCT Q04759 human HEXIM1 10614 O94992 HEXIM1 human S158 25680402 KKHRRRPsKKKRHWk X X -PRKCQ PKCT Q04759 human Radixin 5962 P35241 RDX human T564 448374 AGRDKyKtLRQIRQG ERM_C X 3141; 3726; 32600 -PRKCQ PKCT Q04759 human CARD11 416476 Q5F3W0 RCJMB04_5k17 chicken S668 457639 LERPFRPsVTSVGRI X 5189 -PRKCQ PKCT Q04759 human LLGL1 3996 Q15334 LLGL1 human S663 449917 LkKsLRQsFRRIRKs X -PRKCQ PKCT Q04759 human PDK1 5170 O15530 PDPK1 human S241 447693 skQARANsFVGtAQy Pkinase X 3061; 3438 -PRKCQ PKCT Q04759 human CARD11 84433 Q9BXL7 CARD11 human S893 1876333500 sPRLSRAsFLFGQLL X X -PRKCQ PKCT Q04759 human BAD 572 Q92934 BAD human S75 447860 EIRsRHssyPAGtED Bcl-2_BAD X 9291; 5284; 9296; 5193; 11865; 94223 -PRKCQ PKCT Q04759 human LLGL1 3996 Q15334 LLGL1 human S673 449918 RIRKsRVsGKKRAAN X -PRKCQ PKCT Q04759 human NKD2 85409 Q969F2 NKD2 human S31 23254812 FVASAYAsGRKGAEE X -PRKCQ PKCT Q04759 human Ezrin 7430 P15311 EZR human T567 448104 QGRDkyKtLRQIRQG ERM_C X 3141; 3726; 32600 -PRKCQ PKCT Q04759 human CACNA1C 100101555 P15381 CACB rabbit S1928 455278 ASLGRRAsFHLECLK CAC1F_C X -PRKCQ PKCT Q04759 human PDK1 5170 O15530 PDPK1 human S64 27457101 EPRPGAGsLQHAQPP X -PRKCQ PKCT Q04759 human PDK1 18607 Q9Z2A0 Pdpk1 mouse S532 5938009 TYYLMDPsGNAHKWC PH_3 X -PRKCQ PKCT Q04759 human PKCT 5588 Q04759 PRKCQ human T219 457380 SAINSREtMFHkERF X -PRKCQ PKCT Q04759 human IRS1 3667 P35568 IRS1 human S1101 453434 GCRRRHssEtFsStP X -PRKCQ PKCT Q04759 human RANGAP1 5905 P46060 RANGAP1 human S504 1873645604 LMQKAFNsssFNSNT RanGAP1_C X -PRKCQ PKCT Q04759 human HePTP 5778 P35236 PTPN7 human S246 460715 QYQEERRsVkHILFS Y_phosphatase X -PRKCQ PKCT Q04759 human CARD11 108723 Q8CIS0 Card11 mouse S564 457637 QPHRSRSsIMsItAE X -PRKCQ PKCT Q04759 human girdin 55704 Q3V6T2 CCDC88A human S1690 27811900 LQQFLEEsNKLTSVQ X X -PRKCQ PKCT Q04759 human HPCAL1 3241 P37235 HPCAL1 human T149 1876861206 EStPEKRtDKIFRQM EF-hand_7 X -PRKCQ PKCT Q04759 human RASGRP1 10125 O95267 RASGRP1 human T184 456226 RDWSRKLtQRIKSNT X -PRKCQ PKCT Q04759 human SHP-1 15170 P29351 Ptpn6 mouse S591 454019 DKEKNKGsLKRK___ X -PRKCQ PKCT Q04759 human CARD11 84433 Q9BXL7 CARD11 human S559 457637 QPPRsRssIMsITAE X -PRKCQ PKCT Q04759 human EAR-2 2063 P10588 NR2F6 human S83 25802106 CKSFFKRsIRRNLsY zf-C4 X -PRKCQ PKCT Q04759 human CACNA1C 100101555 P15381 CACB rabbit S528 486358 ARLAHRIsKSKFsRY X -PRKCQ PKCT Q04759 human LLGL1 3996 Q15334 LLGL1 human S655 449915 GPLSRVKsLkKsLRQ X -PRKCQ PKCT Q04759 human CD4 12504 P06332 Cd4 mouse S432 451188 QRQAARMsQIKRLLS Tcell_CD4_C X -PRKCQ PKCT Q04759 human H3 8350 P68431 H3C1 human S10 455676 tkQtArkstGGkAPr Histone X 9701; 9711; 9606; 3465; 3642; 3377; 3475; 3458; 5764; 47398; 8481; 8552; 53348; 29237; 66065; 43185; 64522; 52725 -PRKCQ PKCT Q04759 human AID 11628 Q9WVE0 Aicda mouse S3 20660600 _____MDsLLMKQKK X -PRKCQ PKCT Q04759 human CACNA1C 100101555 P15381 CACB rabbit S533 453091 RIsKSKFsRYWRRWN X -PRKCQ PKCT Q04759 human LLGL1 3996 Q15334 LLGL1 human S659 449916 RVKsLkKsLRQsFRR X -PRKCQ PKCT Q04759 human KRas iso2 3845 P01116-2 KRAS human S181 459210 GKKKKkKskTkCVIM X -PRKCQ PKCT Q04759 human SHP-1 5777 P29350 PTPN6 human S591 454019 DKEKsKGsLKRK___ X -PRKCQ PKCT Q04759 human LLGL1 3996 Q15334 LLGL1 human S670 10405473 sFRRIRKsRVsGKKR X -PRKCQ PKCT Q04759 human FRA1 8061 P15407 FOSL1 human S265 478352 PSSDPLGsPtLLAL_ X 3880; 5841 -PRKCQ PKCT Q04759 human Moesin 4478 P26038 MSN human T558 447706 LGRDKyKtLRQIRQG ERM_C X 3141; 3726; 32600 -PRKCQ PKCT Q04759 human IRS1 16367 P35569 Irs1 mouse S318 451399 MVGGKPGsFRVRASs X 5610 -PRKCQ PKCT Q04759 human WIPF1 7456 O43516 WIPF1 human S488 449880 RNESRSGsNRRErGA X -PRKCQ PKCT Q04759 human RAPGEF2 9693 Q9Y4G8 RAPGEF2 human S960 1245534 KKRVRRssFLNAKKL X X -PRKCQ PKCT Q04759 human PIP5K1B 18719 P70181 Pip5k1b mouse S413 27461455 PSKKRCNsIAALKAT X -PRKCQ PKCT Q04759 human Cbl-b 868 Q13191 CBLB human S282 25802103 KysTKPGsYIFRLSC Cbl_N3 X -PRKCQ PKCT Q04759 human HABP4 22927 Q5JVS0 HABP4 human T375 11380903 GRGARGGtRGGRGRI IHABP4_N X -PRKCQ PKCT Q04759 human STLK3 27347 Q9UEW8 STK39 human S323 450932 LCLQkDPskRPTAAE Pkinase X -PRKCQ PKCT Q04759 human PDK1 18607 Q9Z2A0 Pdpk1 mouse S504 5938008 LKGEIPWsQELRPEA PH_3 X -PRKCQ PKCT Q04759 human HePTP 5778 P35236 PTPN7 human S44 448309 RLQERrGsNVALMLD X -PRKCQ PKCT Q04759 human ICAM3 3385 P32942 ICAM3 human S518 451020 REHQRsGsyHVREEs X -PRKCQ PKCT Q04759 human FRA1 8061 P15407 FOSL1 human T230 27259000 tPSLtPFtPSLVFTY X -PRKCQ PKCT Q04759 human CARD11 108723 Q8CIS0 Card11 mouse S657 457639 LERPFRPsVTSGGHV X 5189 -PRKCQ PKCT Q04759 human FRA1 8061 P15407 FOSL1 human T223 1270901 HtPTLMTtPSLtPFt X -PRKCQ PKCT Q04759 human mGluR5 24418 P31424 Grm5 rat S839 455778 VRSAFTTstVVRMHV X -PRKCQ PKCT Q04759 human CARD11 108723 Q8CIS0 Card11 mouse S649 457638 NLMLRKFsLERPFRP X -PRKCQ PKCT Q04759 human HABP4 22927 Q5JVS0 HABP4 human T354 11380902 RKPANDItSQLEINF IHABP4_N X -PRKCQ PKCT Q04759 human CACNA1C 100101555 P15381 CACB rabbit S1674 480102 QGLVGKPsQRNALSL X -PRKCQ PKCT Q04759 human BAD 572 Q92934 BAD human S99 447862 PFrGrsRsAPPNLWA Bcl-2_BAD X 9295; 5286; 4366 -PRKCQ PKCT Q04759 human MYPT1 4659 O14974 PPP1R12A human T853 452075 PREKRRstGVsFWtQ X 4563 -PRKCQ PKCT Q04759 human RANGAP1 5905 P46060 RANGAP1 human S506 1873645606 QKAFNsssFNSNTFL RanGAP1_C X -PRKCQ PKCT Q04759 human ARHGEF6 9459 Q15052 ARHGEF6 human S225 456738 KSSERPLsPkAVkGF X X -PRKCQ PKCT Q04759 human TBK1 29110 Q9UHD2 TBK1 human S716 4271179 HILERFGsLTMDGGL X X -PRKCQ PKCT Q04759 human ARHGEF6 9459 Q15052 ARHGEF6 human S488 452424 LSASPRMsGFIyQGk PH X X -PRKCQ PKCT Q04759 human STLK3 27347 Q9UEW8 STK39 human S309 450930 MMKKyGKsFRkLLSL Pkinase X -PRKCQ PKCT Q04759 human RASGRP3 25780 Q8IV61 RASGRP3 human T133 454419 YDWMRRVtQRKKVSK X X -Fgr FGR Q6P6U0 rat SDHA Q920L2 Sdha rat Y596 1458603 YkVRIDEyDYSkPIE Succ_DH_flav_C X -Fgr FGR Q6P6U0 rat SDHA Q920L2 Sdha rat Y535 1458604 CEkVSQLyGDLQHLk Succ_DH_flav_C X -Fgr FGR Q6P6U0 rat FGR 79113 Q6P6U0 Fgr rat Y511 448121 FTSTEPQyQPGDQT_ X -Fgr FGR Q6P6U0 rat CK2A1 1457 P68400 CSNK2A1 human Y255 450324 VLGTEDLyDyIDkYN Pkinase X -Fgr FGR Q6P6U0 rat FGR 79113 Q6P6U0 Fgr rat Y400 448120 RLIVDDEyNPQQGTK PK_Tyr_Ser-Thr X -Fgr FGR Q6P6U0 rat ACO2 79250 Q9ER34 Aco2 rat Y544 1458607 FDPGQDTyQHPPkDS X -Fgr FGR Q6P6U0 rat HS1 3059 P14317 HCLS1 human Y222 452057 MEAPttAykkTTPIE X -Fgr FGR Q6P6U0 rat ACO2 79250 Q9ER34 Aco2 rat Y665 1458606 VVIGDENyGEGsSRE Aconitase_C X -Fgr FGR Q6P6U0 rat ACO2 79250 Q9ER34 Aco2 rat Y71 1458605 TLSEkIVyGHLDDPA Aconitase X -PRKACB PKACB P22694 human PKACB 18749 P68181 Prkacb mouse T198 452130 RVKGRtWtLCGtPEY Pkinase X 4781; 5661 -PRKACB PKACB P22694 human AQP2 359 P41181 AQP2 human S256 449854 REVRRRQsVELHsPQ X -PRKACB PKACB P22694 human SFRS2 6427 Q01130 SRSF2 human S121 6422897 GyGrRSRsPRRRRRs X -PRKACB PKACB P22694 human SFRS2 6427 Q01130 SRSF2 human S171 29431801 RSARRsKsksSsVsR X -PRKACB PKACB P22694 human SFRS2 6427 Q01130 SRSF2 human S128 29431802 sPRRRRRsRsRSRSR X -PRKACB PKACB P22694 human NGFR 4804 P08138 NGFR human S303 10432300 PEGEKLHsDsGIsVD X X -PRKACB PKACB P22694 human SFRS2 6427 Q01130 SRSF2 human S130 29431800 RRRRRsRsRSRSRSR X -CSNK1G1 CK1G1 Q9HCP0 human SNCA 6622 P37840 SNCA human T64 1876998407 EktkEQVtNVGGAVV Synuclein X -CSNK1G1 CK1G1 Q9HCP0 human APC 324 P25054 APC human S1507 452097 FsCsssLsALsLDEP APC_r X -CSNK1G1 CK1G1 Q9HCP0 human LRP6 4040 O75581 LRP6 human T1479 457635 SSsstKGtyFPAILN X X -CSNK1G1 CK1G1 Q9HCP0 human SNCA 20617 O55042 Snca mouse T64 1876998407 EKtKEQVtNVGGAVV Synuclein X -CSNK1G1 CK1G1 Q9HCP0 human APC 324 P25054 APC human S1505 452096 DGFsCsssLsALsLD APC_r X -CSNK1G1 CK1G1 Q9HCP0 human NFkB-p65 5970 Q04206 RELA human S536 447800 sGDEDFSsIADMDFS X X 4887; 3036; 3031; 4886; 3033; 4025; 5733; 13346; 76778; 31553; 80477; 73992; 87672; 83962 -CSNK1G1 CK1G1 Q9HCP0 human LYN 4067 P07948 LYN human S13 1983291 SKGkDsLsDDGVDLk X -CSNK1G1 CK1G1 Q9HCP0 human APC 324 P25054 APC human S1510 999606 sssLsALsLDEPFIQ X -CSNK1G1 CK1G1 Q9HCP0 human APC 324 P25054 APC human S1504 999604 PDGFsCsssLsALsL APC_r X -Csnk1e CK1E Q9JMK2 mouse LPIN1 14245 Q91ZP3 Lpin1 mouse S483 471356 VGGsGIDsGVEsTSD X -Csnk1e CK1E Q9JMK2 mouse PER2 18627 O54943 Per2 mouse S659 449331 TLPGKAEsVVsLTSQ X X -Csnk1e CK1E Q9JMK2 mouse PER1 18626 O35973 Per1 mouse S661 451683 SSSYTASsAsDDDKQ X X -Csnk1e CK1E Q9JMK2 mouse DARPP-32 19049 Q60829 Ppp1r1b mouse S130 448046 EEDEEEDsQAEVLKG DARPP-32 X -Csnk1e CK1E Q9JMK2 mouse PER1 18626 O35973 Per1 mouse S663 451684 SYTASsAsDDDKQRA X X -Csnk1e CK1E Q9JMK2 mouse LPIN1 14245 Q91ZP3 Lpin1 mouse S487 62856003 GIDsGVEsTSDSLRD X -Csnk1e CK1E Q9JMK2 mouse DNMT1 13433 P13864 Dnmt1 mouse S146 4702934 ksDsDtLsVEtsPss X -Stk11 LKB1 Q9WTK7 mouse AMPKA1 65248 P54645 Prkaa1 rat T269 450433 VDPMKRAtIKDIREH Pkinase X -Stk11 LKB1 Q9WTK7 mouse AMPKA1 105787 Q5EG47 Prkaa1 mouse S172 15407586 KIADFGLsNMMsDGE Pkinase X -Stk11 LKB1 Q9WTK7 mouse AMPKA2 78975 Q09137 Prkaa2 rat T258 450434 VDPLKRAtIKDIREH Pkinase X -Stk11 LKB1 Q9WTK7 mouse AMPKA1 65248 P54645 Prkaa1 rat T183 448786 SDGEFLRtsCGSPNY Pkinase X 2535; 2531; 4188; 5256; 50081; 74281 -Stk11 LKB1 Q9WTK7 mouse LKB1 20869 Q9WTK7 Stk11 mouse T336 448150 KDRWRSMtVVPYLED X X -Stk11 LKB1 Q9WTK7 mouse AMPKA2 78975 Q09137 Prkaa2 rat S491 450432 StPQRSCsAAGLHRP AdenylateSensor X 4185 -Stk11 LKB1 Q9WTK7 mouse AMPKA1 105787 Q5EG47 Prkaa1 mouse T183 448786 sDGEFLRtsCGsPNY Pkinase X 2535; 2531; 4188; 5256; 50081; 74281 -Stk11 LKB1 Q9WTK7 mouse PAK1 5058 Q13153 PAK1 human T109 14150103 QWARLLQtsNITKsE PBD X -Stk11 LKB1 Q9WTK7 mouse AMPKA1 5562 Q13131 PRKAA1 human T183 448786 sDGEFLRtsCGsPNy Pkinase X 2535; 2531; 4188; 5256; 50081; 74281 -Stk11 LKB1 Q9WTK7 mouse PAK1 18479 O88643 Pak1 mouse T109 14150103 QWARLLQtSNITKsE PBD X -Stk11 LKB1 Q9WTK7 mouse AMPKA1 65248 P54645 Prkaa1 rat S496 450431 AtPQRSGsISNYRSC AdenylateSensor X 4185; 4184; 2537 -Stk11 LKB1 Q9WTK7 mouse LKB1 20869 Q9WTK7 Stk11 mouse T366 448151 IEDGIIytQDFTVPG X X -Stk11 LKB1 Q9WTK7 mouse AMPKA2 78975 Q09137 Prkaa2 rat T172 448026 SDGEFLRtsCGSPNY Pkinase X 2535; 2531; 5256; 50081; 74281 -MAP2K5 MEK5 Q13163 human ERK5 5598 Q13164 MAPK7 human Y221 448206 HQyFMtEyVAtRWYR Pkinase X X -MAP2K5 MEK5 Q13163 human ERK5 5598 Q13164 MAPK7 human T219 448205 AEHQyFMtEyVAtRW Pkinase X X 3371 -Insr INSR P15127 rat INSR 24954 P15127 Insr rat Y1186 447680 FGMTRDIyEtDyyRK PK_Tyr_Ser-Thr X 3021; 80732 -Insr INSR P15127 rat caveolin-2 363425 Q2IBC5 Cav2 rat Y27 454430 sHHSVVDyTDPEKYV Caveolin X X -Insr INSR P15127 rat INSR 24954 P15127 Insr rat Y1362 447684 TyDEHIPyTHMNGGK X -Insr INSR P15127 rat INSR 24954 P15127 Insr rat Y1190 447681 RDIyEtDyyRKGGKG PK_Tyr_Ser-Thr X 3024; 3918; 2969 -Insr INSR P15127 rat caveolin-2 363425 Q2IBC5 Cav2 rat Y19 450198 LFMADDAysHHSVVD Caveolin X X -Insr INSR P15127 rat CBL 867 P22681 CBL human Y700 448529 EGEEDtEyMtPssRP X 8869 -Insr INSR P15127 rat IRS1 25467 P35570 Irs1 rat Y895 447556 EPKsPGEyVNIEFGS X X 3070 -Insr INSR P15127 rat IRS1 25467 P35570 Irs1 rat Y460 451286 GEEELSNyICMGGKG X X -Insr INSR P15127 rat IRS1 25467 P35570 Irs1 rat Y608 447555 NLHtDDGyMPMsPGV X X -Insr INSR P15127 rat IRS1 25467 P35570 Irs1 rat Y1172 451288 GLEKSLNyIDLDLVK X X -Insr INSR P15127 rat CBL 867 P22681 CBL human Y371 449753 TQEQyELyCEMGSTF X -Insr INSR P15127 rat IRS1 25467 P35570 Irs1 rat Y628 447565 NRKGNGDyMPMsPKs X X -Insr INSR P15127 rat CBL 867 P22681 CBL human Y774 448531 sENEDDGyDVPKPPV X 3555 -Insr INSR P15127 rat INSR 24954 P15127 Insr rat Y1191 447682 DIyEtDyyRKGGKGL PK_Tyr_Ser-Thr X 3024; 2969 -Insr INSR P15127 rat IRS1 25467 P35570 Irs1 rat Y1222 448699 ssEDLSTyASINFQK X X 3066 -Insr INSR P15127 rat IRS1 25467 P35570 Irs1 rat Y987 451287 VPNSRGDyMTMQIGC X X -Insr INSR P15127 rat IRS1 25467 P35570 Irs1 rat Y939 448700 EETGSEEyMNMDLGP X X -Insr INSR P15127 rat APS 114203 Q9Z200 Sh2b2 rat Y618 448842 ARAVENQySFY____ X -Insr INSR P15127 rat INSR 24954 P15127 Insr rat Y1356 447683 SLsIKRTyDEHIPyT X -Insr INSR P15127 rat ANXA1 25380 P07150 Anxa1 rat Y21 447974 IEkQEQEyVQAVKSY X -Ephb1 EphB1 Q8CBF3 mouse NCAM-L1 16728 P11627 L1cam mouse Y1232 10272401 DGsFIGQySGKKEKE Bravo_FIGEY X -Rps6ka1 p90RSK Q63531 rat Fos 314322 P12841 Fos rat S362 448481 AAAHRKGsSSNEPSS X -Rps6ka1 p90RSK Q63531 rat BSN 29138 O88778 Bsn rat S2845 456576 KTLQRSLsDPKPLSP X -Rps6ka1 p90RSK Q63531 rat ETV1 2115 P50549 ETV1 human S216 3059600 PMYQRQMsEPNIPFP ETS_PEA3_N X X -Rps6ka1 p90RSK Q63531 rat nNOS 24598 P29476 Nos1 rat S847 447886 SYKVRFNsVSSYSDS Flavodoxin_1 X X -Rps6ka1 p90RSK Q63531 rat p27Kip1 1027 P46527 CDKN1B human T198 448781 PGLRRRQt_______ X X -Rps6ka1 p90RSK Q63531 rat ETV1 2115 P50549 ETV1 human S191 3059602 HRFRRQLsEPCNSFP ETS_PEA3_N X X -Rps6ka1 p90RSK Q63531 rat IkB-alpha 25493 Q63746 Nfkbia rat S32 448203 LVDDRHDsGLDsMKD X 5210; 2859; 9246; 5209 -Rps6ka1 p90RSK Q63531 rat ETV1 2115 P50549 ETV1 human S334 3059601 PTYQRRGsLQLWQFL X -Rps6ka1 p90RSK Q63531 rat p27Kip1 1027 P46527 CDKN1B human S10 447874 NVRVSNGsPsLErMD X -Rps6ka1 p90RSK Q63531 rat IkB-beta 81525 Q9JIA3 Nfkbib rat S23 447916 WCDsGLGsLGPDAAA X X -Rps6ka1 p90RSK Q63531 rat CREB iso1 81646 P15337-1 Creb1 rat S133 448228 EILsRRPsYRkILND pKID X 9187; 9196; 9198; 4095; 14228; 14001; 39561; 80120; 44864; 54960; 95995 -Rps6ka1 p90RSK Q63531 rat NCAM-L1 50687 Q05695 L1cam rat S1154 449315 RSKGGKysVKDKEDT Bravo_FIGEY X -Rps6ka1 p90RSK Q63531 rat NHE1 24782 P26431 Slc9a1 rat S707 448347 MsRARIGsDPLAYEP X -Rps6ka1 p90RSK Q63531 rat C/EBP-beta 24253 P21272 Cebpb rat S105 448425 AKPSKKPsDYGyVsL X 3081 -Rps6ka1 p90RSK Q63531 rat BSN 12217 O88737 Bsn mouse S2860 456576 KTLQRsLsDPKPLsP X -Rps6ka1 p90RSK Q63531 rat IkB-alpha 25493 Q63746 Nfkbia rat S36 448204 RHDsGLDsMKDEDyE X 5210; 9246 -Rps6ka1 p90RSK Q63531 rat IkB-beta 81525 Q9JIA3 Nfkbib rat S19 447917 DADEWCDsGLGsLGP X X -Lats1 LATS1 Q8BYR2 mouse YAP1 22601 P46938 Yap1 mouse S112 448847 PQHVRAHssPAsLQL X X 4911; 13008; 92367; 57706 -Lats1 LATS1 Q8BYR2 mouse AMOT 27494 Q8VHG2 Amot mouse S176 28699604 QGHVRSLsERLMQMs X -Lats1 LATS1 Q8BYR2 mouse TAZ 97064 Q9EPK5 Wwtr1 mouse S89 457660 AQHVRSHssPAsLQL X 75275; 59971 -LTK LTK P29376 human PREB 10113 Q9HCU5 PREB human Y10 1868624703 RRRAPELyRAPFPLY X -MINK1 MINK Q8N4C8 human SMAD1 4086 Q15797 SMAD1 human T322 25802105 sNVNRNStIENTRRH MH2 X X -MINK1 MINK Q8N4C8 human GR 2908 P04150 NR3C1 human T562 1872513501 StWRIMTtLNMLGGR Hormone_recep X -MINK1 MINK Q8N4C8 human SMAD2 17126 Q62432 Smad2 mouse T324 23146436 SNVNRNAtVEMTRRH MH2 X -MINK1 MINK Q8N4C8 human GR 2908 P04150 NR3C1 human T635 1872513505 IINEQRMtLPCMYDQ Hormone_recep X -MINK1 MINK Q8N4C8 human GR 2908 P04150 NR3C1 human T524 1872513504 NKtIVPAtLPQLTPT X -MINK1 MINK Q8N4C8 human LATS1 9113 O95835 LATS1 human T1079 457595 EHAFyEFtFRRFFDD X 8654 -CHEK1 Chk1 O14757 human Src 6714 P12931 SRC human S51 2420700 AdGHRGPsAAFAPAA X X -CHEK1 Chk1 O14757 human SH2BP1 9646 Q6PD62 CTR9 human S1081 10399992 RRPRRQRsDQDsDsD X -CHEK1 Chk1 O14757 human LAMC1 3915 P11047 LAMC1 human T258 28846246 VTLNRLNtFGDEVFN Laminin_N X -CHEK1 Chk1 O14757 human DDX19A 55308 Q9NUU7 DDX19A human S92 27447122 sPLYSVksFEELRLK X -CHEK1 Chk1 O14757 human hnRNP A2/B1 3181 P22626 HNRNPA2B1 human T159 10154941 krGFGFVtFDDHDPV RRM_1 X -CHEK1 Chk1 O14757 human RPL19 6143 P84098 RPL19 human T56 14579426 LIIRkPVtVHsRARC Ribosomal_L19e X -CHEK1 Chk1 O14757 human YB-1 4904 P67809 YBX1 human T80 9412957 GFINRNDtkEDVFVH CSD X -CHEK1 Chk1 O14757 human TICRR 90381 Q7Z2Z1 TICRR human T1898 38520202 RPIsRTYtRKKLMGT X -CHEK1 Chk1 O14757 human BAZ1A 11177 Q9NRL2 BAZ1A human S1320 28846202 RSLRkINsAPPtETk X -CHEK1 Chk1 O14757 human BLM 641 P54132 BLM human S539 10852147 DQNkHtAsINDLERE BDHCT_assoc X -CHEK1 Chk1 O14757 human H3 360198 P68433 H3c1 mouse T11 455680 kQTARkstGGkAPrk Histone X 9767; 9764 -CHEK1 Chk1 O14757 human NFkB-p105 18033 P25799 Nfkb1 mouse S240 34354490 VSDAIyDsKAPNAsN RHD_DNA_bind X -CHEK1 Chk1 O14757 human E2F3 1871 O00716 E2F3 human S124 11929101 PALGrGGsGGGGGPP X X -CHEK1 Chk1 O14757 human Chk1 1111 O14757 CHEK1 human S296 447832 GFskHIQsNLDFsPV X X 2349; 90178 -CHEK1 Chk1 O14757 human TRIP12 9320 Q14669 TRIP12 human S1078 15723449 SGLARAAskDTISNN X -CHEK1 Chk1 O14757 human TLK1 9874 Q9UKI8 TLK1 human S743 449050 PHMRRsNssGNLHMA X X -CHEK1 Chk1 O14757 human CLK3 1198 P49761 CLK3 human S157 2192633 HHCKRyRsPEPDPyL X -CHEK1 Chk1 O14757 human EPRS 2058 P07814 EPRS1 human S910 18910291 VLFDkVAsQGEVVRK WHEP-TRS X -CHEK1 Chk1 O14757 human SETMAR 6419 Q53H47 SETMAR human S508 10940417 LYDNRRRsAQWLDQE Transposase_1 X X -CHEK1 Chk1 O14757 human CK1D 64462 Q06486 Csnk1d rat S328 3190837 PATRGLPstAsGRLR X X -CHEK1 Chk1 O14757 human PROTOR1 55615 P85299 PRR5 human S240 3892597 RLLRRsRsGDVLAkN X -CHEK1 Chk1 O14757 human E2F6 1876 O75461 E2F6 human S52 29609300 EDNVQyVsMRKALKV X -CHEK1 Chk1 O14757 human p53 7157 P04637 TP53 human S37 447532 NVLsPLPsQAMDDLM TAD2 X X 9289 -CHEK1 Chk1 O14757 human p73 7161 O15350 TP73 human S47 452197 EVVGGTDssMDVFHL X X -CHEK1 Chk1 O14757 human GTF3C1 2975 Q12789 GTF3C1 human S667 12260181 VRLVRNLsEEGLLRL X -CHEK1 Chk1 O14757 human p21Cip1 12575 P39689 Cdkn1a mouse T140 447837 QGRKRRQtsLTDFYH X X -CHEK1 Chk1 O14757 human RBM26 64062 Q5T8P6 RBM26 human T839 28846284 TELRRkytELQLEAA X -CHEK1 Chk1 O14757 human p57Kip2 12577 P49919 Cdkn1c mouse S19 22354700 TAMERLAssDTFPVI X X -CHEK1 Chk1 O14757 human CSDA 8531 P16989 YBX3 human T112 9412967 GFINRNDtkEDVFVH CSD X -CHEK1 Chk1 O14757 human INF2 64423 Q27J81 INF2 human S574 28846237 LNWQkLPsNVAREHN FH2 X -CHEK1 Chk1 O14757 human TICRR 90381 Q7Z2Z1 TICRR human S1045 10989971 RsVQRVHsFQQDKsD X -CHEK1 Chk1 O14757 human Chk1 1111 O14757 CHEK1 human T382 1388511400 KRMtRFFtkLDADks X X -CHEK1 Chk1 O14757 human Src 6714 P12931 SRC human Y530 448235 FTstEPQyQPGENL_ X 2105 -CHEK1 Chk1 O14757 human CDC25A 993 P30304 CDC25A human S76 449340 SNLQRMGssEstDsG X X -CHEK1 Chk1 O14757 human CK1D 64462 Q06486 Csnk1d rat S370 483997 MERERKVsMRLHRGA X X -CHEK1 Chk1 O14757 human CK1D 64462 Q06486 Csnk1d rat S331 2192627 RGLPstAsGRLRGTQ X X -CHEK1 Chk1 O14757 human KI-67 4288 P46013 MKI67 human T1764 3148167 RsLRkADtEEEFLAF KI67R X -CHEK1 Chk1 O14757 human TFDP1 7027 Q14186 TFDP1 human S23 3196109 VFIDQNLsPGkGVVS X -CHEK1 Chk1 O14757 human MIG-6 54206 Q9UJM3 ERRFI1 human S302 468194 KPDYRRWsAEVTSST X X -CHEK1 Chk1 O14757 human FANCD2 2177 Q9BXW9 FANCD2 human S331 11315004 KSKGRASsSGNQESS FancD2 X X -CHEK1 Chk1 O14757 human RALY 22913 Q9UKM9 RALY human T160 27455306 PLVrRVktNVPVkLF X -CHEK1 Chk1 O14757 human 53BP1 7158 Q12888 TP53BP1 human S1678 476255 ItsEEERsPAKRGRK X -CHEK1 Chk1 O14757 human ZNF638 27332 Q14966 ZNF638 human S375 28846314 GsKkNYQsQADIPIr X -CHEK1 Chk1 O14757 human SFRS2IP 9169 Q99590 SCAF11 human S1127 3210312 QQsYkRksEQEFsFD X -CHEK1 Chk1 O14757 human SRm300 23524 Q9UQ35 SRRM2 human S2280 28846295 PrTAVAPsAVNLADP X -CHEK1 Chk1 O14757 human NFkB-p65 5970 Q04206 RELA human T505 455490 EAITRLVtGAQRPPD X X -CHEK1 Chk1 O14757 human CHD-7 55636 Q9P2D1 CHD7 human T1227 28846215 AILEKNFtFLSKGGG SNF2-rel_dom X -CHEK1 Chk1 O14757 human GOLGA4 2803 Q13439 GOLGA4 human S71 452809 KLQLRVPsVEsLFRs X -CHEK1 Chk1 O14757 human ADD3 120 Q9UEY8 ADD3 human S693 452158 KKKFRtPsFLKKNKK X -CHEK1 Chk1 O14757 human KIFC1 3833 Q9BW19 KIFC1 human S26 477789 RPLIkAPsQLPLsGs X -CHEK1 Chk1 O14757 human SEPT7 989 Q16181 SEPTIN7 human T228 471456 kIyEFPEtDDEEENk Septin X -CHEK1 Chk1 O14757 human matrin 3 9782 P43243 MATR3 human S195 476155 sFDDrGPsLNPVLDy X -CHEK1 Chk1 O14757 human CDC25A 993 P30304 CDC25A human S124 449127 PALkRSHsDsLDHDI M-inducer_phosp X X -CHEK1 Chk1 O14757 human SCML2 10389 Q9UQR0 SCML2 human S570 478158 MYIHtsVsQDFSRsV X -CHEK1 Chk1 O14757 human SRm300 23524 Q9UQ35 SRRM2 human T2252 28846299 ArtPAIPtAVNLADS X -CHEK1 Chk1 O14757 human MCM5 4174 P33992 MCM5 human T633 28846249 MkLQPFAtEADVEEA MCM_lid X -CHEK1 Chk1 O14757 human SHARP 23013 Q96T58 SPEN human T1059 3640035 IKLDRLNtVAsPKDC X -CHEK1 Chk1 O14757 human LATS2 26524 Q9NRM7 LATS2 human S835 28706304 GSHVRQDsMEPSDLW Pkinase X X -CHEK1 Chk1 O14757 human RAD51 5888 Q06609 RAD51 human T309 455229 LRKGRGEtRICKIyD Rad51 X X -CHEK1 Chk1 O14757 human RIF1 55183 Q5UIP0 RIF1 human S2205 3201699 VNkVRRVsFADPIyQ X -CHEK1 Chk1 O14757 human AurB 9212 Q96GD4 AURKB human S331 22259700 HPWVRANsRRVLPPS X X -CHEK1 Chk1 O14757 human E2F7 52679 Q6S7F2 E2f7 mouse S411 3208641 ERLVRyGsFNTVHTS X X -CHEK1 Chk1 O14757 human CCDC49 54883 Q9NXE8 CWC25 human S337 3214029 PGYTRKLsAEELERK X -CHEK1 Chk1 O14757 human RBM14 10432 Q96PK6 RBM14 human S627 4756664 sQLsFRRsPtKssLD X -CHEK1 Chk1 O14757 human IDI1 3422 Q13907 IDI1 human S55 28846234 GLLHRAFsVFLFNTE NUDIX X -CHEK1 Chk1 O14757 human Chk1 1111 O14757 CHEK1 human T378 1388511401 QRLVKRMtRFFtkLD X X -CHEK1 Chk1 O14757 human CAAP1 79886 Q9H8G2 CAAP1 human S203 2906731 EGDNGMDsDMEEEAD X -CHEK1 Chk1 O14757 human TLK1 9874 Q9UKI8 TLK1 human S679 15406524 KPFGHNQsQQDILQE Pkinase X -CHEK1 Chk1 O14757 human PRRC2C 23215 Q9Y520 PRRC2C human S661 28846200 QPRPAVLsGyFkQFQ X -CHEK1 Chk1 O14757 human TICRR 90381 Q7Z2Z1 TICRR human S865 9764262 NALIRHksIAEVSQN Treslin_N X -CHEK1 Chk1 O14757 human RASSF1 iso2 11186 Q9NS23-2 RASSF1 human T38 30259806 ALRIARGtACNPtRQ X -CHEK1 Chk1 O14757 human PHF2 5253 O75151 PHF2 human S929 28846276 REGtRVAsIETGLAA X -CHEK1 Chk1 O14757 human SNCB 6620 Q16143 SNCB human Y127 22461200 EDPPQEEyQEYEPEA X X -CHEK1 Chk1 O14757 human EXO1 9156 Q9UQ84 EXO1 human S746 1240803 PGLYkSSsADsLStT X X -CHEK1 Chk1 O14757 human PLK1 5347 P53350 PLK1 human T210 448139 YDGERKktLCGtPNy Pkinase X X 4354; 5472; 9062 -CHEK1 Chk1 O14757 human hnRNP M 4670 P52272 HNRNPM human S432 467999 HGMDrVGsEIERMGL X -CHEK1 Chk1 O14757 human MED1 5469 Q15648 MED1 human T704 28846253 PEKPKHQtEDDFQRE X -CHEK1 Chk1 O14757 human CCDC6 8030 Q16204 CCDC6 human S244 450707 QPVsAPPsPRDIsME DUF2046 X -CHEK1 Chk1 O14757 human p53 7157 P04637 TP53 human T387 455224 HkkLMFktEGPDsD_ X X -CHEK1 Chk1 O14757 human TICRR 90381 Q7Z2Z1 TICRR human S1115 7990154 KsHQKsLsFskttPR X -CHEK1 Chk1 O14757 human YBX2 51087 Q9Y2T7 YBX2 human T115 9412983 GFINRNDtkEDVFVH CSD X -CHEK1 Chk1 O14757 human WIZ 58525 O95785 WIZ human S1129 483171 sLEARsPsDLHIsPL X -CHEK1 Chk1 O14757 human NIPA 51530 Q86WB0 ZC3HC1 human T84 28848800 AFFSRVEtFSsLkWA zf-C3HC X -CHEK1 Chk1 O14757 human Hck 3055 P08631 HCK human Y411 448168 RVIEDNEytAREGAk PK_Tyr_Ser-Thr X 2101; 6943; 59548; 70926; 78740; 94361; 17320 -CHEK1 Chk1 O14757 human p53 7157 P04637 TP53 human T18 447541 EPPLsQEtFsDLWkL P53_TAD X 2529 -CHEK1 Chk1 O14757 human ASF1A 25842 Q9Y294 ASF1A human S166 3245981 kLEDAEssNPNLQsL X X -CHEK1 Chk1 O14757 human CDC25A 993 P30304 CDC25A human S178 449126 LFTQRQNsAPARMLs M-inducer_phosp X X -CHEK1 Chk1 O14757 human RASSF1 iso2 11186 Q9NS23-2 RASSF1 human T43 30259807 RGtACNPtRQLVPGR X -CHEK1 Chk1 O14757 human NUP153 9972 P49790 NUP153 human S297 28846270 QMkAkQLsAQSyGVT Nup153 X -CHEK1 Chk1 O14757 human CK1D 64462 Q06486 Csnk1d rat T397 3362909 QDtsRMstsQIPGRV X X -CHEK1 Chk1 O14757 human E2F8 108961 Q58FA4 E2f8 mouse S395 10994497 PSFTRHPsLIKLVKS X X -CHEK1 Chk1 O14757 human p53 7157 P04637 TP53 human S20 447529 PLsQEtFsDLWkLLP P53_TAD X X 9287 -CHEK1 Chk1 O14757 human LATS2 26524 Q9NRM7 LATS2 human S408 17600400 PVPSRTNsFNSHQPR X -CHEK1 Chk1 O14757 human NFkB-p105 18033 P25799 Nfkb1 mouse S326 22771100 VNITKPAsVFVQLRR RHD_dimer X -CHEK1 Chk1 O14757 human MDM4 17248 O35618 Mdm4 mouse S367 457676 PDCRRtIsAPVVRPK X -CHEK1 Chk1 O14757 human SLTM 79811 Q9NWH9 SLTM human S748 7447222 WsENKkLsLDtDARF X -CHEK1 Chk1 O14757 human OGT 8473 O15294 OGT human S20 3174941 EPTkRMLsFQGLAEL X X -CHEK1 Chk1 O14757 human H3 360198 P68433 H3c1 mouse S10 455676 tkQTARkstGGkAPr Histone X 9701; 9711; 9606; 3465; 3642; 3377; 3475; 3458; 5764; 47398; 8481; 8552; 53348; 29237; 66065; 43185; 64522; 52725 -CHEK1 Chk1 O14757 human NEK11 79858 Q8NG66 NEK11 human S273 10433801 SMLNKNPsLRPSAIE Pkinase X X -CHEK1 Chk1 O14757 human RBM28 55131 Q9NW13 RBM28 human S122 3245387 RLIIRNLsFKCSEDD RRM_1 X -CHEK1 Chk1 O14757 human Tau iso8 4137 P10636-8 MAPT human S262 447930 NVKskIGstENLkHQ Tubulin-binding X -CHEK1 Chk1 O14757 human BLM 641 P54132 BLM human T182 41290000 sHFVRVStAQKSKKG BLM_N X X -CHEK1 Chk1 O14757 human SSBP1 6742 Q04837 SSBP1 human S67 4774304 ATNEMWRsGDsEVyQ SSB X -CHEK1 Chk1 O14757 human MDC1 9656 Q14676 MDC1 human T523 481891 sTtVDINtQVEKEVP X -CHEK1 Chk1 O14757 human KPNA2 3838 P52292 KPNA2 human S54 10941719 MLkRRNVssFPDDAt IBB X -CHEK1 Chk1 O14757 human MCM3 4172 P25205 MCM3 human S160 2201400 KtIERRysDLttLVA MCM_OB X -CHEK1 Chk1 O14757 human SRm300 23524 Q9UQ35 SRRM2 human S1499 453299 tPRPRsRsPssPELN X -CHEK1 Chk1 O14757 human Chk1 1111 O14757 CHEK1 human S316 12084535 EENVkYsssQPEPRT X -CHEK1 Chk1 O14757 human POP4 10775 O95707 POP4 human S10 460860 SVIyHALsQkEANDs X -CHEK1 Chk1 O14757 human ADD2 119 P35612 ADD2 human S713 449802 KKKFRtPsFLKKsKK X -CHEK1 Chk1 O14757 human RAVER1 iso2 125950 Q8IY67-2 RAVER1 human S700 15422762 PLGGQkRsFAHLLPs X -CHEK1 Chk1 O14757 human ADD1 118 P35611 ADD1 human S726 449829 KKKFRtPsFLKKsKK X -CHEK1 Chk1 O14757 human ANKRD12 iso2 23253 Q6UB98-2 ANKRD12 human S76 28846100 SRNEERDsDTEKEGP X -CHEK1 Chk1 O14757 human MIG-6 54206 Q9UJM3 ERRFI1 human S251 3215403 RRLRRsHsGPAGsFN X X -CHEK1 Chk1 O14757 human ZNF395 55893 Q9H8N7 ZNF395 human S447 4943578 LSPVRSRsLsFSEPQ X -CHEK1 Chk1 O14757 human Ku70 2547 P12956 XRCC6 human S477 3180585 RFTYrsDsFENPVLQ Ku_C X -CHEK1 Chk1 O14757 human MAD2L1 4085 Q13257 MAD2L1 human S185 4326275 sEEVRLRsFtTTIHk HORMA X -CHEK1 Chk1 O14757 human MST1 6789 Q13043 STK4 human T340 3801524 AVGDEMGtVRVASTM X -CHEK1 Chk1 O14757 human MYCBP2 23077 O75592 MYCBP2 human S3478 467339 TVFQRsYsVVASEYD X -CHEK1 Chk1 O14757 human RPL19 6143 P84098 RPL19 human S12 4272220 rLQKrLAssVLRCGK Ribosomal_L19e X -CHEK1 Chk1 O14757 human BUD13 84811 Q9BRD0 BUD13 human S18 4763637 EYLKRYLsGADAGVD X -CHEK1 Chk1 O14757 human AS160 9882 O60343 TBC1D4 human S588 455920 RMRGRLGsVDsFERs X 8730 -CHEK1 Chk1 O14757 human MEK2 5605 P36507 MAP2K2 human T59 28846262 KRLEAFLtQkAkVGE X -CHEK1 Chk1 O14757 human FAM122A 116224 Q96E09 PABIR1 human S37 3208890 GGLRRsNsAPLIHGL X -CHEK1 Chk1 O14757 human p53 7157 P04637 TP53 human S378 447534 skkGQstsRHkkLMF X -CHEK1 Chk1 O14757 human MAD2L1 4085 Q13257 MAD2L1 human T187 22640014 EVRLRsFtTTIHkVN HORMA X -CHEK1 Chk1 O14757 human E2F6 1876 O75461 E2F6 human S12 27532759 RPARkLPsLLLDPTE X -CHEK1 Chk1 O14757 human CCDC6 8030 Q16204 CCDC6 human S240 452441 EkLDQPVsAPPsPRD DUF2046 X -CHEK1 Chk1 O14757 human DDX24 57062 Q9GZR7 DDX24 human S82 452946 KRKAQAVsEEEEEEE X -CHEK1 Chk1 O14757 human MAP4 4134 P27816 MAP4 human T521 452281 MALGKDVtPPPEtEV X -CHEK1 Chk1 O14757 human Cortactin 2017 Q14247 CTTN human S298 5014901 EKLAkHEsQQDyskG HS1_rep X -CHEK1 Chk1 O14757 human RBM42 79171 Q9BTD8 RBM42 human S406 28846288 RAFSRFPsFLKAKVI RRM_1 X -CHEK1 Chk1 O14757 human RBM14 10432 Q96PK6 RBM14 human S618 468597 LsDyrRLsEsQLsFR X -CHEK1 Chk1 O14757 human FEN1 2237 P39748 FEN1 human T195 15426136 PVLMrHLtAsEAkkL XPG_I X -CHEK1 Chk1 O14757 human EBNA1BP2 10969 Q99848 EBNA1BP2 human T182 28846219 kYGKkVQtEVLQkRQ Ebp2 X -CHEK1 Chk1 O14757 human TIF1B 10155 Q13263 TRIM28 human S473 452391 sGVkRsRsGEGEVsG X -CHEK1 Chk1 O14757 human Chk1 1111 O14757 CHEK1 human S291 10991667 sEsPsGFskHIQsNL X -CHEK1 Chk1 O14757 human RANBP2 5903 P49792 RANBP2 human T1098 15422730 QTIGPrNtFNFGsKN X -CHEK1 Chk1 O14757 human matrin 3 9782 P43243 MATR3 human T150 1218501 LQLkRRRtEEGPtLs X -CHEK1 Chk1 O14757 human MYBBP1A 10514 Q9BQG0 MYBBP1A human S1310 483421 sLVIRsPsLLQsGAk X -CHEK1 Chk1 O14757 human SENP2 59343 Q9HC62 SENP2 human S344 3868126 GLLRRKVsIIEtKEK X -CHEK1 Chk1 O14757 human BLM 641 P54132 BLM human S646 15349300 LKHERFQsLSFPHTk BDHCT_assoc X X -CHEK1 Chk1 O14757 human CAMSAP1L1 23271 Q08AD1 CAMSAP2 human S464 2020305 RGITRsIsNEGLtLN X -CHEK1 Chk1 O14757 human CHTOP 26097 Q9Y3Y2 CHTOP human T212 28846206 ALArPVLtkEQLDNQ FoP_duplication X -CHEK1 Chk1 O14757 human CDC25B 994 P30305 CDC25B human S563 470116 tFRLKTRsWAGERSR X -CHEK1 Chk1 O14757 human HPV16 protein E6 1489078 P03126 E6 papillomavirus T156 1884110701 SSRTRREtQL_____ X -CHEK1 Chk1 O14757 human BAT2L 84726 Q5JSZ5 PRRC2B human S166 483694 RGSSrLLsFsPEEFP BAT2_N X -CHEK1 Chk1 O14757 human RBM14 10432 Q96PK6 RBM14 human T629 456092 LsFRRsPtKssLDyR X -CHEK1 Chk1 O14757 human lamin A/C 4000 P02545 LMNA human S307 5450481 DsLsAQLsQLQkQLA Filament X -CHEK1 Chk1 O14757 human H3 8350 P68431 H3C1 human T11 455680 kQtArkstGGkAPrk Histone X 9767; 9764 -CHEK1 Chk1 O14757 human MDM4 4194 O15151 MDM4 human S342 470031 SkLTHSLsTSDITAI X -CHEK1 Chk1 O14757 human ZBTB11 27107 O95625 ZBTB11 human S537 28846310 KRKAVPKsAVQQVAQ X -CHEK1 Chk1 O14757 human PHF8 23133 Q9UPP1 PHF8 human S904 17556614 REGtRVAsIEtGLAA X -CHEK1 Chk1 O14757 human MgcRacGAP 29127 Q9H0H5 RACGAP1 human S203 459866 GPVkKTRsIGsAVDQ X -CHEK1 Chk1 O14757 human DDX19B 11269 Q9UMR2 DDX19B human S93 27447125 sPLYSVksFEELRLK X -CHEK1 Chk1 O14757 human TLK2 11011 Q86UE8 TLK2 human S686 15406527 KPFGHNQsQQDILQE Pkinase X -CHEK1 Chk1 O14757 human ARHGEF2 9181 Q92974 ARHGEF2 human S172 460815 LGLRRILsQstDsLN X -CHEK1 Chk1 O14757 human PPME1 51400 Q9Y570 PPME1 human S15 476688 MHLGRLPsrPPLPGs X -CHEK1 Chk1 O14757 human H3F3A 3020 P84243 H3-3A human S31 18545303 AARksAPsTGGVkkP Histone X X -CHEK1 Chk1 O14757 human matrin 3 9782 P43243 MATR3 human S4 4761999 ____MsksFQQssLs X -CHEK1 Chk1 O14757 human MAP4 4134 P27816 MAP4 human T925 476126 PRLSRLAtNtsAPDL X -CHEK1 Chk1 O14757 human ING1 iso2 3621 Q9UK53-2 ING1 human S126 484008 LGDTAGNsGKAGADR X -CHEK1 Chk1 O14757 human PRPF3 9129 O43395 PRPF3 human S161 28846280 EERKkQLsFIsPPtP X -CHEK1 Chk1 O14757 human AS160 9882 O60343 TBC1D4 human S485 4755108 LVIQRHLssLtDNEQ X -CHEK1 Chk1 O14757 human p53 7157 P04637 TP53 human S15 447490 PsVEPPLsQEtFsDL P53_TAD X X 4030; 9235; 9284; 9286; 8695; 8514; 82530; 56979 -CHEK1 Chk1 O14757 human vigilin 3069 Q00341 HDLBP human T8 28846306 MSSVAVLtQEsFAEH X -CHEK1 Chk1 O14757 human PROSER2 254427 Q86WR7 PROSER2 human S43 480487 SSSSRsRsFtLDDEs X -CHEK1 Chk1 O14757 human CDK13 8621 Q14004 CDK13 human S437 451875 RsRsRHssIsPstLT X -CHEK1 Chk1 O14757 human NHS 4810 Q6T4R5 NHS human T401 3203073 RKLRRRKtIsGIPRR X -CHEK1 Chk1 O14757 human RRP12 23223 Q5JTH9 RRP12 human S1049 483802 AKRHRALsQAAVEEE X -CHEK1 Chk1 O14757 human claspin 63967 Q9HAW4 CLSPN human T916 455334 DELLDLCtGKFTsQA X X -CHEK1 Chk1 O14757 human PPP2R5D 5528 Q14738 PPP2R5D human S60 457388 PsSNKRPsNstPPPt X X -CHEK1 Chk1 O14757 human p21Cip1 12575 P39689 Cdkn1a mouse S141 447836 GRKRRQtsLTDFYHS X X -CHEK1 Chk1 O14757 human DRG2 1819 P55039 DRG2 human S72 23100718 VALIGFPsVGKSTFL MMR_HSR1 X -CHEK1 Chk1 O14757 human PLRG1 5356 O43660 PLRG1 human S119 9316251 TkIQRMPsEsAAQsL X -CHEK1 Chk1 O14757 human HIVEP1 3096 P15822 HIVEP1 human S1749 3180926 ASSKRMLsPANsLDI X -CHEK1 Chk1 O14757 human SRm300 23524 Q9UQ35 SRRM2 human S2388 15428491 tsPrVPLsAyErVsG X -CHEK1 Chk1 O14757 human RASSF1 iso2 11186 Q9NS23-2 RASSF1 human S184 7447198 PssKKPPsLQDARRG X X -CHEK1 Chk1 O14757 human ELG 55421 Q53F19 NCBP3 human S100 28846223 AkRFHFRsEVNLAQR X -CHEK1 Chk1 O14757 human ZBTB11 27107 O95625 ZBTB11 human S511 15416798 RSRLRQRsVNEGAyI X -CHEK1 Chk1 O14757 human CDC25A 993 P30304 CDC25A human T507 450483 KFRTKSRtWAGEKsK X X -CHEK1 Chk1 O14757 human FANCE 2178 Q9HB96 FANCE human T346 476781 LGLLRLCtWLLALSP FA_FANCE X X -CHEK1 Chk1 O14757 human Src 6714 P12931 SRC human Y419 448234 RLIEDNEytARQGAk PK_Tyr_Ser-Thr X 2101; 6943; 59548; 70926; 78740; 94361; 17320 -CHEK1 Chk1 O14757 human FYTTD1 84248 Q96QD9 FYTTD1 human T205 28846231 KVQAQLNtEQLLDDV FYTT X -CHEK1 Chk1 O14757 human CDK1 983 P06493 CDK1 human S208 28846209 kPLFHGDsEIDQLFR Pkinase X -CHEK1 Chk1 O14757 human MIG-6 313729 P05432 Errfi1 rat S250 3215403 RRLRRsHsGPAGSFN X -CHEK1 Chk1 O14757 human NFkB-p105 18033 P25799 Nfkb1 mouse S335 449967 FVQLRRKsDLETSEP RHD_dimer X -CHEK1 Chk1 O14757 human PLK1 5347 P53350 PLK1 human S137 448138 LELCRRRsLLELHkR Pkinase X X -CHEK1 Chk1 O14757 human SKAR 84271 Q9BY77 POLDIP3 human S63 18015794 ARQKIGLsDArLKLG X -CHEK1 Chk1 O14757 human BLM 641 P54132 BLM human S502 34666301 HLQksFVsSNWAEtP BDHCT_assoc X X -CHEK1 Chk1 O14757 human RPL13 6137 P26373 RPL13 human T170 28846292 KEKARVItEEEkNFk Ribosomal_L13e X -CHEK1 Chk1 O14757 human LIG1 3978 P18858 LIG1 human S76 449246 EEEDEALsPAkGQKP X -CHEK1 Chk1 O14757 human CK2B 1460 P67870 CSNK2B human T213 2902202 NFksPVktIR_____ X -CHEK1 Chk1 O14757 human Syk 6850 P43405 SYK human S295 7445408 GIISRIKsysFPKPG X X -CHEK1 Chk1 O14757 human KPNA1 3836 P52294 KPNA1 human S18 28846243 LKsYKNKsLNPDEMR IBB X -CHEK1 Chk1 O14757 human MINK 50488 Q8N4C8 MINK1 human T280 28846267 TYLSRPPtEQLLKFP Pkinase X -CHEK1 Chk1 O14757 human CDC25C 995 P30307 CDC25C human S216 448418 sGLyRsPsMPENLNR M-inducer_phosp X 9528; 4901; 30790 -CHEK1 Chk1 O14757 human SLTM 79811 Q9NWH9 SLTM human S815 27459212 TARREDPsFERYPKN X -CHEK1 Chk1 O14757 human MEK1 5604 Q02750 MAP2K1 human T55 28846257 KRLEAFLtQkQKVGE X -CHEK1 Chk1 O14757 human TICRR 90381 Q7Z2Z1 TICRR human S1894 38520201 FSRRRPIsRTYtRKK X -CHEK1 Chk1 O14757 human Rb 5925 P06400 RB1 human S612 447977 MyLsPVRsPKKKGsT X -CHEK1 Chk1 O14757 human NFkB-p105 4790 P19838 NFKB1 human S328 22771100 INItkPAsVFVQLRR RHD_dimer X X -CHEK1 Chk1 O14757 human OSBPL11 114885 Q9BXB4 OSBPL11 human S189 468350 PIsQRRPsQNAIsFF X -CHEK1 Chk1 O14757 human FANCE 2178 Q9HB96 FANCE human S374 476782 LFLGRILsLTSSASR FA_FANCE X X -CHEK1 Chk1 O14757 human RAP80 51720 Q96RL1 UIMC1 human S627 472426 HSEGRLLsFLEQsEH X -CHEK1 Chk1 O14757 human CDC25A 993 P30304 CDC25A human S279 449129 VLKRPErsQEEsPPG M-inducer_phosp X X -CHEK1 Chk1 O14757 human CDC25A 993 P30304 CDC25A human S293 449128 GSTKrRKsMsGASPk M-inducer_phosp X X -CHEK1 Chk1 O14757 human SIN3A 25942 Q96ST3 SIN3A human T434 9257992 IRRHPtGttPPVKKK X -CHEK1 Chk1 O14757 human SRm300 23524 Q9UQ35 SRRM2 human S1497 457062 PQtPRPRsRsPssPE X -CHEK1 Chk1 O14757 human CDC25B 994 P30305 CDC25B human S230 470115 AFAQRPssAPDLMCL M-inducer_phosp X X -CHEK1 Chk1 O14757 human NUP153 9972 P49790 NUP153 human S330 468335 ADAkRIPsIVssPLN Nup153 X -CHEK1 Chk1 O14757 human TNK1 8711 Q13470 TNK1 human S502 483166 RMKGIsRsLEsVLsL X -CHEK1 Chk1 O14757 human EML3 256364 Q32P44 EML3 human S176 483689 KLSRkAIssANLLVR X -CHEK1 Chk1 O14757 human CEP170B 283638 Q9Y4F5 CEP170B human S655 3217287 QGLPVPGsPGGQKWV X -CHEK1 Chk1 O14757 human LMO7 4008 Q8WWI1 LMO7 human S1510 457018 GIMRRGEsLDNLDsP X -CHEK1 Chk1 O14757 human MDM4 4194 O15151 MDM4 human S367 457676 PDCRRtIsAPVVRPk X X -CHEK1 Chk1 O14757 human NFkB-p105 18033 P25799 Nfkb1 mouse S246 1170753400 DsKAPNAsNLKIVRM X -PRKACA PKACA P17612 human GLI1 2735 P08151 GLI1 human T374 457674 PGCTkRYtDPSSLRK zf-C2H2 X -PRKACA PKACA P17612 human CUTL1 1523 P39880 CUX1 human S1270 460701 YQQKPYPsPKTIEDL Homeodomain X -PRKACA PKACA P17612 human GSK3B 84027 P18266 Gsk3b rat S9 449111 SGRPRTTsFAESCKP X 9336; 9331; 9327; 9323; 9322; 9325; 5558; 8566; 79774; 8466; 25462; 14026; 14332; 14310; 14630 -PRKACA PKACA P17612 human CDK16 5127 Q00536 CDK16 human S119 453450 EDINkRLsLPADIRL X -PRKACA PKACA P17612 human eNOS 4846 P29474 NOS3 human T495 447885 TGITRKKtFKEVANA X 9574 -PRKACA PKACA P17612 human MAP2 4133 P11137 MAP2 human S1679 456808 NVKsKIGstDNIKYQ Tubulin-binding X X -PRKACA PKACA P17612 human SHIP 16331 Q9ES52 Inpp5d mouse S1161 4778452 AVLQLQHsKGRDyRD X -PRKACA PKACA P17612 human CIITA 4261 P33076 CIITA human S1050 448442 AASLLRLsLYNNCIC LRR_6 X X -PRKACA PKACA P17612 human MAPKAPK5 8550 Q8IW41 MAPKAPK5 human S115 18704700 GELFHRIsQHRHFTE Pkinase X -PRKACA PKACA P17612 human RKIP 29542 P31044 Pebp1 rat S51 3189670 TQVMNRPssIsWDGL PBP X -PRKACA PKACA P17612 human CAMKK2 10645 Q96RR4 CAMKK2 human S495 469882 kTMIRKRsFGNPFEG X 16737; 35392 -PRKACA PKACA P17612 human NEDD4L 23327 Q96PU5 NEDD4L human S342 453438 ssRLRsCsVtDAVAE X X 12146 -PRKACA PKACA P17612 human SRC-3 8202 Q9Y6Q9 NCOA3 human S857 453084 PPYNRAVsLDsPVsV X -PRKACA PKACA P17612 human RASD1 19416 O35626 Rasd1 mouse S253 50402002 APFARRPsVHSDLMY X -PRKACA PKACA P17612 human CAMKK1 60341 P97756 Camkk1 rat S52 2864202 PPRARAAsVIPGsAs X -PRKACA PKACA P17612 human PPP2R5D 5528 Q14738 PPP2R5D human S75 457389 QLSkIkysGGPQIVk X -PRKACA PKACA P17612 human Rb 5925 P06400 RB1 human S780 447978 strPPtLsPIPHIPr Rb_C X 9307; 3590; 8180 -PRKACA PKACA P17612 human MYBPC1 iso2 109272 G0YZM8 Mybpc1 mouse S204 4738635 IRSAFKRsGEGQEDA X -PRKACA PKACA P17612 human HEXIM1 10614 O94992 HEXIM1 human S158 25680402 KKHRRRPsKKKRHWk X X -PRKACA PKACA P17612 human SHIP 16331 Q9ES52 Inpp5d mouse S972 4778440 PPsQPPLsPKKFsSS X -PRKACA PKACA P17612 human ATP6V1A 11964 P50516 Atp6v1a mouse S175 14913505 LPPRNRGsVTYIAPP ATP-synt_ab_Xtn X X -PRKACA PKACA P17612 human CACNA1D 29716 P27732 Cacna1d rat T2147 6062706 EMESAAStLLNGsVC CAC1F_C X -PRKACA PKACA P17612 human GLI3 2737 P10071 GLI3 human S980 25780315 VHAPRRCsDGGAHGY X X -PRKACA PKACA P17612 human APOA1BP 246703 Q8K4Z3 Naxe mouse S43 4763049 WGTQRRGsEtMAGAA X -PRKACA PKACA P17612 human CACNA1C 775 Q13936 CACNA1C human S1535 460572 DYLTRDWsILGPHHL Ion_trans X -PRKACA PKACA P17612 human RYR2 20191 E9Q401 Ryr2 mouse S2030 455603 TIRGRLLsLVEkVTY X X -PRKACA PKACA P17612 human Kv7.2 iso4 3785 O43526-4 KCNQ2 human S455 4788663 SKVPKSWsFGDRSRA KCNQ_channel X -PRKACA PKACA P17612 human PLCG1 5335 P19174 PLCG1 human S1248 448665 HGrAREGsFEsRyQQ X X 4510; 13349; 8713 -PRKACA PKACA P17612 human ASIC1 iso1 41 P78348-1 ASIC1 human S525 449558 QKEAKRSsADKGVAL X X -PRKACA PKACA P17612 human PPAR-alpha 25747 P37230 Ppara rat T129 457548 CKGFFRRtIRLKLAY zf-C4 X -PRKACA PKACA P17612 human DISC1 27185 Q9NRI5 DISC1 human S58 18942701 GPGIGFLsPAVGTLF X -PRKACA PKACA P17612 human CASP9 842 P55211 CASP9 human S99 471400 NRQAAkLskPTLENL X -PRKACA PKACA P17612 human MYBPC3 4607 Q14896 MYBPC3 human S284 471080 AGGGRRIsDsHEDtG X -PRKACA PKACA P17612 human GATA4 2626 P43694 GATA4 human S262 450013 IkPQRRLsAsRRVGL X -PRKACA PKACA P17612 human neurabin 1 55607 Q9ULJ8 PPP1R9A human S460 455523 ANRKIKFsSAPIKVF PDZ_5 X -PRKACA PKACA P17612 human CHCHD3 54927 Q9NX63 CHCHD3 human T11 4038300 TTSTRRVtFEADENE X -PRKACA PKACA P17612 human E2F1 1869 Q01094 E2F1 human T130 1870773101 GEkSRYEtSLNLttK E2F_TDP X -PRKACA PKACA P17612 human SHIP 16331 Q9ES52 Inpp5d mouse S173 15621803 TLFQRLQsMDTSGLP X -PRKACA PKACA P17612 human DACT1 51339 Q9NYF0 DACT1 human S827 18159800 KKILRFRsGSLKLMT Dapper X -PRKACA PKACA P17612 human HSL 16890 P54310 Lipe mouse S557 448803 PtESMRRsVsEAALA X 4139 -PRKACA PKACA P17612 human MARK3 4140 P27448 MARK3 human T507 470095 GGMtRRNtyVCsERT X X -PRKACA PKACA P17612 human PAR-4 64513 Q62627 Pawr rat T155 456964 LREKRRStGVVNIPA X X 2329 -PRKACA PKACA P17612 human NHE3 24784 P26433 Slc9a3 rat S552 450899 AEGERRGsLAFIRSP X -PRKACA PKACA P17612 human GRK1 24013 Q9WVL4 Grk1 mouse S21 456353 AFIAARGsFDGSSTP X -PRKACA PKACA P17612 human RPS19 P17074 Rps19 rat S59 7113803 WFYTRAAsTARHLYL Ribosomal_S19e X -PRKACA PKACA P17612 human LC3A 362245 Q6XVN8 Map1lc3a rat S12 15116600 RPFKQRRsFADRCKE X -PRKACA PKACA P17612 human AID 11628 Q9WVE0 Aicda mouse T27 471423 WAKGRHEtYLCYVVK APOBEC2 X -PRKACA PKACA P17612 human RASGRF1 5923 Q13972 RASGRF1 human S927 448487 KEKYRRMsLASAGFP X X -PRKACA PKACA P17612 human H1F1 80838 P43275 H1f1 mouse S129 3302705 VsVKAKAsGAAKKPK X -PRKACA PKACA P17612 human Spinophilin 217124 Q6R891 Ppp1r9b mouse S94 448728 SDRGVRLsLPRAssL X -PRKACA PKACA P17612 human RASGRP2 19395 Q9QUG9 Rasgrp2 mouse S117 468585 EGNRRHssLIDIESV X X -PRKACA PKACA P17612 human CFTR 1080 P13569 CFTR human S670 3333405 TETLHRFsLEGDAPV CFTR_R X -PRKACA PKACA P17612 human CCND1 595 P24385 CCND1 human S197 451828 ATDVKFIsNPPSMVA Cyclin_C X -PRKACA PKACA P17612 human RAP1B 327708 P61223 RAP1B cow S179 451799 PGKARKKssCQLL__ X -PRKACA PKACA P17612 human DUOX1 53905 Q9NRD9 DUOX1 human S955 6370301 KDLCRRAsyIsQDMI X X -PRKACA PKACA P17612 human SCN5A 6331 Q14524 SCN5A human S524 27281504 RTsMKPRssrGsIFt Na_trans_cytopl X -PRKACA PKACA P17612 human NFkB-p105 4790 P19838 NFKB1 human S337 449967 FVQLRRKsDLETSEP RHD_dimer X X -PRKACA PKACA P17612 human MEN1 29417 Q9WVR8 Men1 rat S487 18012114 RRGPRREsKPEEPPP Menin X X -PRKACA PKACA P17612 human MST4 51765 Q9P289 STK26 human T178 4274125 DtQIkRNtFVGtPFW Pkinase X -PRKACA PKACA P17612 human Kv11.1 3757 Q12809 KCNH2 human S1137 4696829 EGPTRRLsLPGQLGA X X -PRKACA PKACA P17612 human PLB 5350 P26678 PLN human S16 448114 RSAIRRAstIEMPQQ Phospholamban X X 8496 -PRKACA PKACA P17612 human PDE4A 25638 P54748 Pde4a rat S140 458389 TTSQRREsFLYRSDs X -PRKACA PKACA P17612 human CACNA1D 29716 P27732 Cacna1d rat S45 6062713 GPTSQPNssKQtVLs X -PRKACA PKACA P17612 human FOXO1A 2308 Q12778 FOXO1 human S153 1253812000 AGQPRKSsSSRRNAW X X -PRKACA PKACA P17612 human MYBPC3 4607 Q14896 MYBPC3 human S311 2846505 sFRtPRDsKLEAPAE X -PRKACA PKACA P17612 human TNNI3 511094 P08057 TNNI3 cow S44 450690 AKKKSKIsAsRKLQL X -PRKACA PKACA P17612 human MAZ 100008693 O97600 MAZ rabbit T386 449095 KDRLRAHtVRHEEKV X -PRKACA PKACA P17612 human AMPKA1 105787 Q5EG47 Prkaa1 mouse S496 450431 AtPQRsGsIsNYRsC AdenylateSensor X 4185; 4184; 2537 -PRKACA PKACA P17612 human CAPN1 823 P07384 CAPN1 human S474 27445498 ANAsRARsEQFINLR Calpain_III X -PRKACA PKACA P17612 human CACNA1C 100101555 P15381 CACB rabbit S1928 455278 ASLGRRAsFHLECLK CAC1F_C X X -PRKACA PKACA P17612 human CAMKK2 10645 Q96RR4 CAMKK2 human S511 2861414 RREERsLsAPGNLLT X 12818 -PRKACA PKACA P17612 human PHOX2A 401 O14813 PHOX2A human S153 9400302 RKQERAAsAkGAAGA X X -PRKACA PKACA P17612 human GFAP 2670 P14136 GFAP human S38 449621 LGPGTRLsLARMPPP Filament_head X -PRKACA PKACA P17612 human ETV1 2115 P50549 ETV1 human S216 3059600 PMYQRQMsEPNIPFP ETS_PEA3_N X X -PRKACA PKACA P17612 human SRF 6722 P11831 SRF human T159 449631 DNkLRRYtTFsKRkT SRF-TF X X -PRKACA PKACA P17612 human DRP1 10059 O00429 DNM1L human S637 483971 VPVARKLsAREQRDC X X 4867; 6319 -PRKACA PKACA P17612 human HSL 3991 Q05469 LIPE human S951 450195 GFHPRRssQGAtQMP Abhydrolase_3 X -PRKACA PKACA P17612 human Tau 17762 P10637 Mapt mouse S701 449132 DtsPRHLsNVsstGs X -PRKACA PKACA P17612 human NFL 18039 P08551 Nefl mouse S56 451024 ssLsVRRsyssSSGs Filament_head X -PRKACA PKACA P17612 human RYR2 689560 B0LPN4 Ryr2 rat S2804 458801 IsQTsQVsIDAAHGY X X -PRKACA PKACA P17612 human VASP 7408 P50552 VASP human T278 448381 LARRRKAtQVGEktP X -PRKACA PKACA P17612 human STAR 101844174 P70114 Star hamster S55 450439 ISQVRRRssLLGSQL X -PRKACA PKACA P17612 human Kv11.1 3757 Q12809 KCNH2 human S890 3893409 RQRKRKLsFRRRtDK X X -PRKACA PKACA P17612 human TRPC5 7224 Q9UL62 TRPC5 human S794 20834807 SGGARAKsKsVSFNL X -PRKACA PKACA P17612 human CK1D 64462 Q06486 Csnk1d rat S370 483997 MERERKVsMRLHRGA X X -PRKACA PKACA P17612 human smMLCK 396445 P11799 MYLK chicken S140 41411900 KTPGGRLsVPPVEHR X -PRKACA PKACA P17612 human IGFBP1 3484 P08833 IGFBP1 human S199 51637400 ETsGEEIsKFYLPNC Thyroglobulin_1 X -PRKACA PKACA P17612 human gephyrin 64845 Q03555 Gphn rat S337 481401 NILRAsHsAVDITKV X -PRKACA PKACA P17612 human RGS4 100009014 Q0R4E4 RGS4 rabbit S52 469585 VVVCQRVsQEEVKKW X -PRKACA PKACA P17612 human CACNA1B 257648 Q02294 Cacna1b rat S2126 467286 SEKQRFYsCDRFGsR X -PRKACA PKACA P17612 human desmin 1674 P17661 DES human T17 449613 RVssYRRtFGGAPGF Filament_head X -PRKACA PKACA P17612 human CHKB 1120 Q9Y259 CHKB human S39 5208526 TPKRRRAssLsRDAE X X -PRKACA PKACA P17612 human ADRB2 154 P07550 ADRB2 human S345 447910 ELLCLRRssLKAyGN X -PRKACA PKACA P17612 human CASK 29647 Q62915 Cask rat S562 12568400 MLREMRGsITFKIVP PDZ X -PRKACA PKACA P17612 human CEACAM1 634 P13688 CEACAM1 human S461 6311908 FGKtGRAsDQRDLTE X -PRKACA PKACA P17612 human NMDAR1 14810 P35438 Grin1 mouse S897 448256 sFKRRRssKDTSTGG X -PRKACA PKACA P17612 human HCN4 330953 O70507 Hcn4 mouse S1113 4699512 RAGGGSGsSGGLGPP X -PRKACA PKACA P17612 human HSD17B13 345275 Q7Z5P4 HSD17B13 human S33 4765436 FIPQRRKsVAGEIVL X X -PRKACA PKACA P17612 human mGluR7 81672 P35400 Grm7 rat S862 2846504 NVQKRKRsFKAVVTA X -PRKACA PKACA P17612 human PDE4D iso2 5144 Q08499-2 PDE4D human S13 2188800 NFPFRRHsWICFDVD X -PRKACA PKACA P17612 human CACNA1D 29716 P27732 Cacna1d rat S121 6062715 PIRRACIsIVDWKPF X -PRKACA PKACA P17612 human IGFBP1 3484 P08833 IGFBP1 human S144 451659 NFHLMAPsEEDHSIL X -PRKACA PKACA P17612 human PFKP 100009526 P47859 PFKP rabbit S12 458323 VSASPRGsYRKFLEH X -PRKACA PKACA P17612 human 14-3-3 zeta 7534 P63104 YWHAZ human S58 449833 VVGARRssWRVVssI 14-3-3 X X 52631 -PRKACA PKACA P17612 human ACC1 iso2 60581 P11497-2 Acaca rat S1192 448290 TSHPNRMsFASNLNH ACC_central X -PRKACA PKACA P17612 human STMN1 29332 P13668 Stmn1 rat S63 448557 AAEERRKsHEAEVLk Stathmin X -PRKACA PKACA P17612 human VAX2 24113 Q9WTP9 Vax2 mouse S170 470130 RDLEKRAssSASEAF X X -PRKACA PKACA P17612 human TXA2-R iso2 6915 P21731-2 TBXA2R human T332 18790000 TRPRRsLtLWPSLEY X -PRKACA PKACA P17612 human IP3R1 16438 P11881 Itpr1 mouse S1588 450681 RNAARRDsVLAAsRD X X -PRKACA PKACA P17612 human BRSK2 9024 Q8IWQ3 BRSK2 human T260 470033 VDAARRLtLEHIQKH Pkinase X -PRKACA PKACA P17612 human NUDE1 iso1 54820 Q9NXR1-1 NDE1 human S306 476557 DGGERRPsstsVPLG NUDE_C X -PRKACA PKACA P17612 human HIF1A 3091 Q16665 HIF1A human S465 56589707 tPkPLRSsADPALNQ X -PRKACA PKACA P17612 human PARP1 142 P09874 PARP1 human S465 34729900 FLQDVSAsTkSLQEL X X -PRKACA PKACA P17612 human FcoR 100503924 P0DJI6 Fcor mouse T93 25244200 DLNSQRStCCCLLNA X -PRKACA PKACA P17612 human ACC1 60581 P11497 Acaca rat S77 448291 LAFHMRSsMsGLHLV X -PRKACA PKACA P17612 human TRPC6 7225 Q9Y210 TRPC6 human T70 470868 RLAHRRQtVLREKGR X X -PRKACA PKACA P17612 human CTPS 1503 P17812 CTPS1 human T455 473570 MRLGKRRtLFQTkNs GATase X -PRKACA PKACA P17612 human NFAT2 4772 O95644 NFATC1 human S245 448861 PSTsPRAsVTEEsWL X X -PRKACA PKACA P17612 human DDX25 29118 Q9UHL0 DDX25 human T239 1868227101 KLKLIDLtKIRVFVL DEAD X -PRKACA PKACA P17612 human H1R 3269 P35367 HRH1 human S398 450937 WKRLRsHsRQyVSGL 7tm_1 X -PRKACA PKACA P17612 human Kir4.1 29718 P49655 Kcnj10 rat S377 2243103 sALSVRIsNV_____ X -PRKACA PKACA P17612 human RGS18 64407 Q9NS28 RGS18 human S216 4772683 PTNLRRRsRsFTCNE X X -PRKACA PKACA P17612 human TPH1 7166 P17752 TPH1 human S260 36439500 TQYVRHSsDPFYTPE Biopterin_H X -PRKACA PKACA P17612 human SCN5A 6331 Q14524 SCN5A human S525 451568 TsMKPRssrGsIFtF Na_trans_cytopl X -PRKACA PKACA P17612 human rabphilin 3A 171039 P47709 Rph3a rat S234 455904 GPPTRRAsEARMSTT X -PRKACA PKACA P17612 human Ret 5979 P07949 RET human S696 451267 SSGARRPsLDsMENQ X X -PRKACA PKACA P17612 human CFTR 1080 P13569 CFTR human S753 451646 EAILPRIsVISTGPT CFTR_R X -PRKACA PKACA P17612 human CACNA1D 29716 P27732 Cacna1d rat T504 6062720 KRRGAAKtGPSGCRR X -PRKACA PKACA P17612 human AP-2 alpha 7020 P05549 TFAP2A human S239 457400 AEVQRRLsPPECLNA TF_AP-2 X X -PRKACA PKACA P17612 human PDE4B 5142 Q07343 PDE4B human S133 449097 GHSQRREsFLYRsDs X -PRKACA PKACA P17612 human TXA2-R iso2 6915 P21731-2 TBXA2R human S330 18790001 LSTRPRRsLtLWPSL X X -PRKACA PKACA P17612 human CHKB 1120 Q9Y259 CHKB human S40 3857922 PKRRRAssLsRDAER X X -PRKACA PKACA P17612 human Spinophilin 84686 O35274 Ppp1r9b rat S100 448729 LsLPRAssLNENVDH X -PRKACA PKACA P17612 human GJD2 14617 O54851 Gjd2 mouse S293 471387 GAQAKRKsVYEIRNK X -PRKACA PKACA P17612 human TNNI3 511094 P08057 TNNI3 cow S25 448424 PPVRRRssANYRAYA Troponin-I_N X -PRKACA PKACA P17612 human OFD1 8481 O75665 OFD1 human S735 480374 GTSSRRLsstPLPkA X X -PRKACA PKACA P17612 human AID 57379 Q9GZX7 AICDA human S38 457604 YVVKRRDsATsFsLD APOBEC2 X X -PRKACA PKACA P17612 human HSP27 3315 P04792 HSPB1 human T143 471871 RCFtRkytLPPGVDP HSP20 X -PRKACA PKACA P17612 human SHIP 16331 Q9ES52 Inpp5d mouse S1023 15406096 FENPLyGsVSSFPKL X -PRKACA PKACA P17612 human GIRK4 3762 P48544 KCNJ5 human S412 27523603 EPKGLGGsREARGSV X -PRKACA PKACA P17612 human Titin 84015 XP_008773743 Ttn rat S3658 29618902 ETSARGLsVQAFDSE X -PRKACA PKACA P17612 human ITPKA 228550 Q8R071 Itpka mouse S119 4763186 LQQPRRLstSSLSST X -PRKACA PKACA P17612 human ENSA 2029 O43768 ENSA human S109 477819 DLPQRkssLVtskLA Endosulfine X -PRKACA PKACA P17612 human TRPA1 8989 O75762 TRPA1 human S972 62873400 AEVQKHAsLKRIAMQ Ion_trans X -PRKACA PKACA P17612 human GluR1 14799 P23818 Gria1 mouse S863 448566 tstLPRNsGAGASGG X 8084 -PRKACA PKACA P17612 human HIR 116649 P52190 Kcnj4 rat S444 9819904 NISYRREsAI_____ X -PRKACA PKACA P17612 human RGS13 6003 O14921 RGS13 human T41 15785722 SFENLMAtKYGPVVy RGS X -PRKACA PKACA P17612 human STAR 25557 P97826 Star rat S55 450439 MGQVRRRssLLGSQL X -PRKACA PKACA P17612 human CTNNB1 1499 P35222 CTNNB1 human S675 457120 QDykKRLsVELtsSL X X 9567; 4176; 68076 -PRKACA PKACA P17612 human CACNA1D 29716 P27732 Cacna1d rat S923 6062711 IAPIPEGsAFFILsK X -PRKACA PKACA P17612 human PKACA 282322 P00517 PRKACA cow S140 469999 LRRIGRFsEPHARFY Pkinase X -PRKACA PKACA P17612 human GSTA4 2941 O15217 GSTA4 human S189 455666 QEYTVKLsNIPtIKR GST_C_3 X -PRKACA PKACA P17612 human PFKFB2 5208 O60825 PFKFB2 human S466 448460 PVRMRRNsFtPLssS X -PRKACA PKACA P17612 human CFTR 1080 P13569 CFTR human S737 449981 EPLERRLsLVPDSEQ CFTR_R X X -PRKACA PKACA P17612 human Tau iso2 4137 P10636-2 MAPT human S320 449132 DTsPRHLsNVSSTGS X -PRKACA PKACA P17612 human TRPV4 63873 Q9EPK8 Trpv4 mouse S824 4777181 LRRDRWssVVPRVVE X -PRKACA PKACA P17612 human RRAD 6236 P55042 RRAD human S273 457396 AGTRRREsLGKKAKR X -PRKACA PKACA P17612 human Src 396442 P00523 SRC chicken S17 448231 DPsQRRRsLEPPDST X X -PRKACA PKACA P17612 human TH iso4 7054 P07101-4 TH human S44 448545 RFIGRRQsLIEDARK TOH_N X 2791 -PRKACA PKACA P17612 human RAP1GAP 5909 P47736 RAP1GAP human S499 3190708 PFGsRRssAIGIENI X X -PRKACA PKACA P17612 human CACNA1D 29716 P27732 Cacna1d rat S858 6062719 EVNQIANsDNKVtID X -PRKACA PKACA P17612 human KCNN2 3781 Q9H2S1 KCNN2 human S464 460687 QAIHQLRsVkMEQRK CaMBD X X -PRKACA PKACA P17612 human PRKD1 18760 Q62101 Prkd1 mouse S427 4960330 KHTKRRSsTVMKEGW X X -PRKACA PKACA P17612 human NFAT2 4772 O95644 NFATC1 human S269 448862 PCNKRKYsLNGRQPP X X -PRKACA PKACA P17612 human CACNA1D 29716 P27732 Cacna1d rat S1944 6062708 DSPIGYDsRRsPRRR CAC1F_C X -PRKACA PKACA P17612 human PPP1R1A 5502 Q13522 PPP1R1A human T35 447759 QIRRRRPtPATLVLT DARPP-32 X -PRKACA PKACA P17612 human DNCLI1 252902 Q9QXU8 Dync1li1 rat T213 3217776 AsPQRRAtAAQEDRD DLIC X X -PRKACA PKACA P17612 human TRIM71 131405 Q2Q1W2 TRIM71 human S3 18914372 _____MAsFPETDFQ X -PRKACA PKACA P17612 human MAP2 iso3 25595 P15146-3 Map2 rat S184 470351 KSPEKRSsLPRPsSI X -PRKACA PKACA P17612 human QSK 23387 Q9Y2K2 SIK3 human S626 3216774 FsPVRRFsDGAAsIQ X -PRKACA PKACA P17612 human CACNA1H 8912 O95180 CACNA1H human S1107 6729300 LPDsRRGsSsSGDPP X -PRKACA PKACA P17612 human myomesin 2 9172 P54296 MYOM2 human S76 466426 RVCAKRVstQEDEEQ X X -PRKACA PKACA P17612 human CFTR 1080 P13569 CFTR human S712 455297 INsIRKFsIVQKTPL CFTR_R X X -PRKACA PKACA P17612 human SHIP 16331 Q9ES52 Inpp5d mouse S269 4778398 ITMVAKLsQLTSLLS X -PRKACA PKACA P17612 human ABHD5 67469 Q9DBL9 Abhd5 mouse S239 36744500 PDFKRKYsSMFEDDT X -PRKACA PKACA P17612 human GIRK1 50599 P63251 Kcnj3 rat T407 10769101 PsKLQKItGREDFPK X -PRKACA PKACA P17612 human HIF1A 3091 Q16665 HIF1A human T63 56589703 KASVMRLtISyLRVR X X -PRKACA PKACA P17612 human SYT12 171180 Q920N7 Syt12 mouse S97 473040 GPPSRKGsLSIEDTF X -PRKACA PKACA P17612 human PKD2L1 9033 Q9P0L9 PKD2L1 human S685 394791405 KLGRsIVssPQGKSG X -PRKACA PKACA P17612 human TAL1 21349 P22091 Tal1 mouse S172 4704529 NRVKRRPsPYEMEIS X X -PRKACA PKACA P17612 human ABCA1 19 O95477 ABCA1 human S1042 455499 GGMQRKLsVALAFVG TM; ABC_tran X -PRKACA PKACA P17612 human LRRK2 66725 Q5S006 Lrrk2 mouse S935 4725898 NAQRHSNsLGPVFDH X X 59576 -PRKACA PKACA P17612 human VTN 7448 P04004 VTN human S397 452178 NQNsRRPsRATWLSL X -PRKACA PKACA P17612 human ORAI1 84876 Q96D31 ORAI1 human S34 48990000 sRRsRRRsGDGEPPG X -PRKACA PKACA P17612 human CPEB3 208922 Q7TN99 Cpeb3 mouse S420 54003200 GRRRGRssLFPFEDA X X -PRKACA PKACA P17612 human KCNN4 3783 O15554 KCNN4 human S334 452145 KHtRRKEsHAARRHQ CaMBD X -PRKACA PKACA P17612 human NLGN2 117096 Q62888 Nlgn2 rat S714 487169 ELRCRRLsPPGGSGS X X -PRKACA PKACA P17612 human CACNA1C BAA34185.2 CACNA1C guinea pig S1574 467228 VACKRLVsMNMPLNS GPHH X X -PRKACA PKACA P17612 human HCN4 330953 O70507 Hcn4 mouse S1140 4699517 TLPRKtssGsLPPPL X -PRKACA PKACA P17612 human perilipin 1 103968 Q8CGN5 Plin1 mouse S492 459628 EKPARRVsDsFFRPs X -PRKACA PKACA P17612 human AKAP12 9590 Q02952 AKAP12 human S772 34663200 LVtPRKksKSkLEEK WSK X X -PRKACA PKACA P17612 human RPS19 P17074 Rps19 rat S90 7113804 QRNGVRPsHFSRGSK Ribosomal_S19e X -PRKACA PKACA P17612 human GIRK1 50599 P63251 Kcnj3 rat S385 4706226 NSKERHNsVECLDGL X -PRKACA PKACA P17612 human PKACA 282322 P00517 PRKACA cow S54 9768111 IKtLGTGsFGRVMLV Pkinase X -PRKACA PKACA P17612 human Tau iso8 4137 P10636-8 MAPT human S320 450139 VDLskVtskCGsLGN Tubulin-binding X -PRKACA PKACA P17612 human syndecan-1 20969 P18828 Sdc1 mouse S286 469564 MKKkDEGsYsLEEPK Syndecan X X -PRKACA PKACA P17612 human PPP1R14A 94274 Q96A00 PPP1R14A human T38 449098 QkRHARVtVkYDRRE PP1_inhibitor X -PRKACA PKACA P17612 human GCM1 8521 Q9NP62 GCM1 human S275 18788304 LsSSRTYsSGDLLPP X X -PRKACA PKACA P17612 human p47phox 653361 P14598 NCF1 human S320 451726 QRsRKRLsQDAYRRN NECFESHC X -PRKACA PKACA P17612 human Claudin-16 155268 Q91Y55 Cldn16 rat S217 2872000 AGVSMAKsyKAPRTE X X -PRKACA PKACA P17612 human GluR4 29629 P19493 Gria4 rat S862 448810 TRNKARLsITGSVGE X X -PRKACA PKACA P17612 human PDE4B 18578 Q8VBU5 Pde4b mouse S118 449097 GHSQRREsFLYRSDs X -PRKACA PKACA P17612 human RAP1GAP2 23108 Q684P5 RAP1GAP2 human S7 455267 _MFGRKRsVsFGGFG X -PRKACA PKACA P17612 human NOXA1 10811 Q86UR1 NOXA1 human S172 990300 DQVQRRGsLPPRQVP X X -PRKACA PKACA P17612 human UHRF1 29128 Q96T88 UHRF1 human S298 2902206 DNPMRRKsGPSCkHC X X -PRKACA PKACA P17612 human CACNA1D 29716 P27732 Cacna1d rat S519 6062714 WGQAIsKsKLRSHGA X -PRKACA PKACA P17612 human ER-alpha 2099 P03372 ESR1 human S236 448739 IDKNRRKsCQACRLR zf-C4 X X -PRKACA PKACA P17612 human CDC25B 12531 P30306 Cdc25b mouse S321 448409 QRLFRsPsMPCSVIR M-inducer_phosp X X -PRKACA PKACA P17612 human SMTNL1 68678 Q99LM3 Smtnl1 mouse S301 2755200 RAPERRVsAPSRPRG X -PRKACA PKACA P17612 human CACNA1S 100009585 P07293 CACNA1S rabbit S1575 6064601 PEIRRTIsGDLtAEE X -PRKACA PKACA P17612 human SMN 6606 Q16637 SMN1 human S187 9316349 sDNIkPksAPWNsFL SMN X -PRKACA PKACA P17612 human PLB 414755 P61012 PLN dog S16 448114 RSAIRRAstIEMPQQ Phospholamban X 8496 -PRKACA PKACA P17612 human MYBPC3 4607 Q14896 MYBPC3 human S304 471081 SLLKKRDsFRtPRDs X -PRKACA PKACA P17612 human HIF1A 3091 Q16665 HIF1A human S727 56589705 RkMEHDGsLFQAVGI X -PRKACA PKACA P17612 human PPP2R5D 21770 Q7TNL5 Ppp2r5d mouse S68 457389 QLSKIKYsGGPQIVK X -PRKACA PKACA P17612 human JMJD1A 55818 Q9Y4C1 KDM3A human S265 453894 GAVKRKssENNGTLV X X -PRKACA PKACA P17612 human MEF2B iso2 100271849 Q02080-2 MEF2B human S324 29649500 sIkSERLsPAPGGPG X -PRKACA PKACA P17612 human PHF2 5253 O75151 PHF2 human S899 4169511 RSKKRKGsDDAPYsP X X -PRKACA PKACA P17612 human PAH 24616 P04176 Pah rat S16 449074 GVLSRKLsDFGQETS X -PRKACA PKACA P17612 human smMLCK 100009143 P29294 MYLK rabbit S1011 468782 SsTGSPTsPLTAERL X X -PRKACA PKACA P17612 human PHF2 5253 O75151 PHF2 human S1056 11138771 FLTQRRPsAssPNNN X X -PRKACA PKACA P17612 human TNNI3 7137 P19429 TNNI3 human S23 448423 PAPIRRRssNyRAyA Troponin-I_N X X 4004 -PRKACA PKACA P17612 human HDAC4 9759 P56524 HDAC4 human S265 4737971 QKVAERRssPLLRRK X X -PRKACA PKACA P17612 human profilin 1 5216 P07737 PFN1 human S138 2850008 MAsHLRRsQy_____ Profilin X X -PRKACA PKACA P17612 human CDK16 5127 Q00536 CDK16 human S110 453449 NHPPRkIstEDINkR X -PRKACA PKACA P17612 human TFAM 7019 Q00059 TFAM human S56 27530801 CPKkPVssYLRFskE HMG_box X -PRKACA PKACA P17612 human GPKOW 27238 Q92917 GPKOW human T316 21127301 GTASSRktLWNQELy X X -PRKACA PKACA P17612 human ATG16L1 iso3 55054 Q676U5-3 ATG16L1 human S269 460725 RAATKRLsQPAGGLL X X -PRKACA PKACA P17612 human PDE4D iso6 5144 Q08499-6 PDE4D human S126 458388 VHSQRREsFLYRSDs X -PRKACA PKACA P17612 human PTP-PEST 5782 Q05209 PTPN12 human S435 451312 KKLERNLsFEIKKVP X X -PRKACA PKACA P17612 human LXR-alpha 22259 Q9Z0Y9 Nr1h3 mouse S291 479434 QIALLKtsAIEVMLL Hormone_recep X X -PRKACA PKACA P17612 human SYNE1 64009 Q6ZWR6 Syne1 mouse S1366 30310303 SSHERFLsFSsLEsL X -PRKACA PKACA P17612 human LRRK2 120892 Q5S007 LRRK2 human S1443 15785705 FNIKARAsssPVILV Roc X -PRKACA PKACA P17612 human IRS2 384783 P81122 Irs2 mouse S1137 487314 QGGRRRHssEtFSsT X -PRKACA PKACA P17612 human Titin 22138 A2ASS6 Ttn mouse S3993 29618903 TEEGKsLsFPLALEE X -PRKACA PKACA P17612 human MBP 618684 P02687 MBP cow T33 451756 FLPRHRDtGILDSLG Myelin_MBP X -PRKACA PKACA P17612 human PJA2 9867 O43164 PJA2 human T389 18713701 RVItQREtENNQMTs X X -PRKACA PKACA P17612 human GRK7 131890 Q8WTQ7 GRK7 human S36 456355 ELQRRRRsLALPGLQ X -PRKACA PKACA P17612 human HCN4 330953 O70507 Hcn4 mouse S990 15103401 PPRPERPsFMAGAsG X -PRKACA PKACA P17612 human STMN1 3925 P16949 STMN1 human S63 448557 AAEERRksHEAEVLk Stathmin X -PRKACA PKACA P17612 human mucolipin 1 57192 Q9GZU1 MCOLN1 human S559 1233700 kFRRGsGsACsLLCC X X -PRKACA PKACA P17612 human eNOS 24600 Q62600 Nos3 rat S632 448637 WRRKRKEsSNTDSAG Flavodoxin_1 X -PRKACA PKACA P17612 human FAK iso5 396416 Q92063 PTK2 chicken S148 449622 LKPDVRLsRGsIERE X -PRKACA PKACA P17612 human APOBEC3B 9582 Q9UH17 APOBEC3B human T214 1869951800 LVLRRRQtYLCYEVE NAD2 X X -PRKACA PKACA P17612 human PIN1 5300 Q13526 PIN1 human S71 18710000 HsQSRRPssWRQEKI Rotamase X -PRKACA PKACA P17612 human RPT6 5705 P62195 PSMC5 human S120 483970 RVALRNDsyTLHkIL Prot_ATP_ID_OB X X -PRKACA PKACA P17612 human RARA 5914 P10276 RARA human S369 451381 YVRKRRPsRPHMFPK Hormone_recep X X -PRKACA PKACA P17612 human NFkB-p65 309165 Q7TQN4 Rela rat S276 447798 SMQLRRPsDRELSEP RHD_dimer X -PRKACA PKACA P17612 human K8 25626 Q10758 Krt8 rat S43 456883 SsFsRVGsssssFRG Keratin_2_head X -PRKACA PKACA P17612 human IP3R1 25262 P29994 Itpr1 rat S1589 450681 RNAARRDsVLAASRD X -PRKACA PKACA P17612 human AQP2 359 P41181 AQP2 human S256 449854 REVRRRQsVELHsPQ X -PRKACA PKACA P17612 human PEDF 5176 P36955 SERPINF1 human S227 455233 KFDSRKTsLEDFYLD Serpin X -PRKACA PKACA P17612 human CAMKK1 84254 Q8N5S9 CAMKK1 human S74 452115 sLsARkLsLQERPAG X -PRKACA PKACA P17612 human RMP 8725 O94763 URI1 human S372 1028301 AKRKRKNstGsGHsA X X -PRKACA PKACA P17612 human PDE4C iso2 5143 Q08493-2 PDE4C human S13 458390 PHSQRREsFLYRSDS X -PRKACA PKACA P17612 human CTNNB1 1499 P35222 CTNNB1 human S45 447488 GATtTAPsLsGkGNP X X 9565; 9564; 24710; 70034; 19807; 96727; 77605 -PRKACA PKACA P17612 human E2F1 1869 Q01094 E2F1 human S364 449403 PLLSRMGsLRAPVDE X -PRKACA PKACA P17612 human Tau iso8 4137 P10636-8 MAPT human S262 447930 NVKskIGstENLkHQ Tubulin-binding X -PRKACA PKACA P17612 human TNNI3 7137 P19429 TNNI3 human S166 3146609 LGARAKEsLDLRAHL Troponin X -PRKACA PKACA P17612 human Tau 4137 P10636 MAPT human S726 449132 DtsPRHLsNVsstGs X -PRKACA PKACA P17612 human ADRB2 154 P07550 ADRB2 human S346 447911 LLCLRRssLKAyGNG X -PRKACA PKACA P17612 human MAP2 iso3 25595 P15146-3 Map2 rat S435 3558891 VASPRRLsNVsSSGs X -PRKACA PKACA P17612 human ADCY8 11514 P97490 Adcy8 mouse S113 26392110 VFPERSGsGSASGSG X X -PRKACA PKACA P17612 human ATPIF1 93974 Q9UII2 ATP5IF1 human S39 27444486 NVDRGAGsIrEAGGA IATP X -PRKACA PKACA P17612 human TRPV5 56302 Q9NQA5 TRPV5 human T708 4710939 WEILRQNtLGHLNLG X -PRKACA PKACA P17612 human HCN4 330953 O70507 Hcn4 mouse S110 15103406 LGsRGGGsGGAGGGs X -PRKACA PKACA P17612 human RAP1A 5906 P62834 RAP1A human S180 450928 KKKPKKKsCLLL___ X -PRKACA PKACA P17612 human N-CoR1 9611 O75376 NCOR1 human S70 3828921 QQLRRRPsLLsEFHP X -PRKACA PKACA P17612 human PDE11A 50940 Q9HCR9 PDE11A human S117 2243101 GNLQRRAsQKELRKS X -PRKACA PKACA P17612 human KCNJ12 117052 P52188 Kcnj12 rat S425 2150913 ERPYRREsEI_____ X -PRKACA PKACA P17612 human NDR1 11329 Q15208 STK38 human S11 22553320 tGstPCssMsNHtkE X -PRKACA PKACA P17612 human CAMKK1 84254 Q8N5S9 CAMKK1 human S475 486103 RrEErsMsAPGNLLV X -PRKACA PKACA P17612 human TRPC5 7224 Q9UL62 TRPC5 human S796 20834808 GARAKsKsVSFNLGC X -PRKACA PKACA P17612 human PLM 476487 P56513 FXYD1 dog S83 451424 EEGTFRSsIRRLstR X -PRKACA PKACA P17612 human PPAR-alpha 25747 P37230 Ppara rat S163 22342300 CRFHKCLsVGMSHNA zf-C4 X -PRKACA PKACA P17612 human MEF2C 17260 Q8CFN5 Mef2c mouse T20 455602 DERNRQVtFTKRKFG SRF-TF X -PRKACA PKACA P17612 human HDAC4 9759 P56524 HDAC4 human S266 4737976 KVAERRssPLLRRKD X X -PRKACA PKACA P17612 human CAD 101843763 P08955 Cad hamster S1406 451249 GAGGRRLsSFVTKGY MGS X -PRKACA PKACA P17612 human HSL 25330 P15304 Lipe rat S863 448803 LTESMRRsVsEAALA X -PRKACA PKACA P17612 human SYT12 191595 P97610 Syt12 rat S97 473040 GPPSRKGsLsIEDTF X -PRKACA PKACA P17612 human NFL 281348 P02548 NEFL cow S56 451024 SSLSVRRsYsSSSGs Filament_head X -PRKACA PKACA P17612 human SMN 6606 Q16637 SMN1 human S5 2021209 ___MAMssGGsGGGV X X -PRKACA PKACA P17612 human SSB 20823 P32067 Ssb mouse S199 2862901 KNEERKQsKVEAKLK X -PRKACA PKACA P17612 human SIRT1 93759 Q923E4 Sirt1 mouse S434 22568200 LLIVIGSsLKVRPVA SIR2 X -PRKACA PKACA P17612 human PFKL 25741 P30835 Pfkl rat T773 458321 LEHVTRRtLsIDKGF X -PRKACA PKACA P17612 human KSR 8844 Q8IVT5 KSR1 human S888 14993200 PKLNRRLsHPGHFWK X -PRKACA PKACA P17612 human GLI1 2735 P08151 GLI1 human S544 457677 VsLERRSssSSSISS X -PRKACA PKACA P17612 human PPP1R1A P01099 PPP1R1A rabbit T35 447759 QIRRRRPtPATLVLT DARPP-32 X -PRKACA PKACA P17612 human AKAP12 9590 Q02952 AKAP12 human S698 455890 RARRGsssDEEGGPK X X -PRKACA PKACA P17612 human STAR 25557 P97826 Star rat S194 450442 RCTKRRGsTCVLAGM START X -PRKACA PKACA P17612 human ABCC9 25560 Q63563 Abcc9 rat T632 483974 FESCKKHtGVQsKPI X -PRKACA PKACA P17612 human APP 11820 P12023 App mouse S679 480465 DAEFGHDsGFEVRHQ Beta-APP X X -PRKACA PKACA P17612 human BRF1 677 Q07352 ZFP36L1 human S54 2475300 GGFPRRHsVtLPSSk Tis11B_N X X -PRKACA PKACA P17612 human DOCK1 1793 Q14185 DOCK1 human S1250 28698600 HAKLLKWsEDVCVAH DHR-2_Lobe_A X X -PRKACA PKACA P17612 human L-plastin 3936 P13796 LCP1 human S5 450852 ___MARGsVsDEEMM X X -PRKACA PKACA P17612 human MYBPC3 17868 O70468 Mybpc3 mouse S546 4699427 kkLEVyQsIADLAVG I-set X -PRKACA PKACA P17612 human TNNI3 29248 P23693 Tnni3 rat S23 448423 PAPVRRRssANYRAY Troponin-I_N X 4004 -PRKACA PKACA P17612 human HDC 3067 P19113 HDC human S195 1884002000 YASDQAHsSVEKAGL X -PRKACA PKACA P17612 human QSK 23387 Q9Y2K2 SIK3 human S551 468543 GPLGRRAsDGGANIQ X -PRKACA PKACA P17612 human SOX9 6662 P48436 SOX9 human S64 451039 EPDLkKEsEEDkFPV Sox_N X X -PRKACA PKACA P17612 human eNOS 24600 Q62600 Nos3 rat S1176 447884 TSRIRtQsFsLQERQ X 9570 -PRKACA PKACA P17612 human RhoGDI alpha 396 P52565 ARHGDIA human S174 452196 kGMLARGsYsIkSRF Rho_GDI X X -PRKACA PKACA P17612 human AMPKA1 65248 P54645 Prkaa1 rat S496 450431 AtPQRSGsISNYRSC AdenylateSensor X 4185; 4184; 2537 -PRKACA PKACA P17612 human CRYBB2 287011 P02522 CRYBB2 cow S204 451609 QRGAFHPsS______ X -PRKACA PKACA P17612 human Tau 17762 P10637 Mapt mouse S506 447929 GsRsRtPsLPtPPtR X 77348 -PRKACA PKACA P17612 human NEDD4L 23327 Q96PU5 NEDD4L human S448 453440 IRRPRsLssPtVtLS X X 8063 -PRKACA PKACA P17612 human RRAD 56437 O88667 Rrad mouse S26 4700219 ERDRRrGstPWGPAP X -PRKACA PKACA P17612 human HIF1A 3091 Q16665 HIF1A human S809 56589709 VNAPIQGsRNLLQGE HIF-1a_CTAD X -PRKACA PKACA P17612 human DNAJC5 79130 P60905 Dnajc5 rat S10 448129 DQRQRsLsTsGEsLY X -PRKACA PKACA P17612 human AA-NAT 443531 Q29495 AANAT sheep S205 452142 HAALRRNsDR_____ X -PRKACA PKACA P17612 human RGS10 6001 O43665 RGS10 human S176 455907 QTAAKRAsRIYNT__ X -PRKACA PKACA P17612 human Claudin-3 1365 O15551 CLDN3 human T192 455751 PPREKKytAtkVVys X X -PRKACA PKACA P17612 human Tau iso8 4137 P10636-8 MAPT human S324 449328 kVtskCGsLGNIHHk Tubulin-binding X -PRKACA PKACA P17612 human CACNA1D 29716 P27732 Cacna1d rat S517 6062716 RRWGQAIsKsKLRSH X -PRKACA PKACA P17612 human K8 25626 Q10758 Krt8 rat S13 13201904 TQKsYKMsTSGPRAF Keratin_2_head X -PRKACA PKACA P17612 human CACNB1 100009109 P19517 CACNB1 rabbit T205 17552137 VTGTRRPtPPASGNE X -PRKACA PKACA P17612 human SREBP-1 iso1 78968 P56720-1 Srebf1 rat S308 458357 IEKRYRSsINDKIVE HLH X -PRKACA PKACA P17612 human H3F3A 3020 P84243 H3-3A human S10 18545301 tkQTARkstGGkAPR Histone X 9706; 3458 -PRKACA PKACA P17612 human SUN2 25777 Q9UH99 SUN2 human S54 448845 SSNMKRLsPAPQLGP X -PRKACA PKACA P17612 human KEPI 81706 Q8TAE6 PPP1R14C human T73 10296602 RHQQGKVtVkYDRKE PP1_inhibitor X -PRKACA PKACA P17612 human ATG16L1 iso2 55054 Q676U5-2 ATG16L1 human S268 3202215 SRAAtRRsVSSFPVP X X -PRKACA PKACA P17612 human PPP2R5D 21770 Q7TNL5 Ppp2r5d mouse S566 457390 KVLLRRKsELPQDVy X -PRKACA PKACA P17612 human CSK 1445 P41240 CSK human S364 448477 ALREKKFsTKSDVWS PK_Tyr_Ser-Thr X X -PRKACA PKACA P17612 human K8 25626 Q10758 Krt8 rat S24 448538 PRAFssRsFtsGPGA Keratin_2_head X -PRKACA PKACA P17612 human Titin 84015 XP_008773743 Ttn rat T3952 2523800 SDLLSKEtLFSSIPK X -PRKACA PKACA P17612 human ROMK iso2 P35560-2 Kcnj1 rat S200 2461201 RVANLRKsLLIGSHI IRK_C X X -PRKACA PKACA P17612 human Lck 3932 P06239 LCK human S42 447819 tLLIRNGsEVRDPLV X -PRKACA PKACA P17612 human MST3 8428 Q9Y6E0 STK24 human T18 452058 ALNKRRAtLPHPGGS X X -PRKACA PKACA P17612 human MYBPC3 17868 O70468 Mybpc3 mouse S730 1877150012 VETTKDRsVFtVEGA I-set X -PRKACA PKACA P17612 human TPH2 121278 Q8IWU9 TPH2 human S19 470085 YWARRGFsLDSAVPE X X -PRKACA PKACA P17612 human PLM 476487 P56513 FXYD1 dog S88 451425 RSsIRRLstRRR___ X -PRKACA PKACA P17612 human MYBPC3 17868 O70468 Mybpc3 mouse S690 1877150010 VTQGKkAsAGPHPDA I-set X -PRKACA PKACA P17612 human QIK 235344 Q8CFH6 Sik2 mouse S343 2150903 RLKSHRssFPVEQRL X -PRKACA PKACA P17612 human TH 21823 P24529 Th mouse S40 448545 RFIGRRQsLIEDARK TOH_N X 2791 -PRKACA PKACA P17612 human PKACA 282322 P00517 PRKACA cow S326 9768114 FKGPGDTsNFDDYEE X -PRKACA PKACA P17612 human CYP2B6 24300 P00176 Cyp2b1 rat S128 448738 WKALRRFsLATMRDF p450 X -PRKACA PKACA P17612 human CES1D iso2 113902 NP_579829 Ces1d rat S506 3540200 ANFARNGsPNGGGLP COesterase X -PRKACA PKACA P17612 human CAPN2 824 P17655 CAPN2 human S369 451303 DGNWRRGstAGGCRN Calpain_III X -PRKACA PKACA P17612 human ARPP-21 618648 Q7M2N1 ARPP-21 cow S56 1096600 QNQERRKsKSGAGKG X -PRKACA PKACA P17612 human LRRK2 120892 Q5S007 LRRK2 human S935 4725898 NLQRHsNsLGPIFDH X 59576 -PRKACA PKACA P17612 human STAR 25557 P97826 Star rat S276 450443 HLRKRLEsSPASEAQ START X -PRKACA PKACA P17612 human BAD 12015 Q61337 Bad mouse S112 447860 ETRsRHssyPAGtEE Bcl-2_BAD X 9291; 5284; 9296; 5193; 11865; 94223 -PRKACA PKACA P17612 human PGC-1 alpha 19017 O70343 Ppargc1a mouse S194 13861601 SWSNKAKsICQQQkP X X -PRKACA PKACA P17612 human RORA iso2 19883 P51448-2 Rora mouse S99 19009803 MSKKQRDsLYAEVQK X -PRKACA PKACA P17612 human PKACA 282322 P00517 PRKACA cow S260 9768113 SGKVRFPsHFSSDLK Pkinase X -PRKACA PKACA P17612 human TRPA1 8989 O75762 TRPA1 human S317 4752026 ETMLHRAsLFDHHEL Ank_2 X -PRKACA PKACA P17612 human Lu 4059 P50895 BCAM human S621 455912 sGGARGGsGGFGDEC X -PRKACA PKACA P17612 human NPM1 18148 Q61937 Npm1 mouse T95 456130 sLGGFEItPPVVLRL Nucleoplasmin X 3517 -PRKACA PKACA P17612 human MAP2 iso3 25595 P15146-3 Map2 rat T220 2999205 ISSARRTtRSEPIRR X -PRKACA PKACA P17612 human NPM1 18148 Q61937 Npm1 mouse S48 14577038 QLsLRTVsLGAGAkD Nucleoplasmin X -PRKACA PKACA P17612 human CFTR 12638 P26361 Cftr mouse S737 3116903 RLsLVPDsEQGEAAL CFTR_R X -PRKACA PKACA P17612 human CAMKK1 60341 P97756 Camkk1 rat S475 486103 RREERSMsAPGNLLL X -PRKACA PKACA P17612 human AKAP12 9590 Q02952 AKAP12 human S696 480148 kKRARRGsssDEEGG X X -PRKACA PKACA P17612 human CREB iso1 81646 P15337-1 Creb1 rat S133 448228 EILsRRPsYRkILND pKID X X 9187; 9196; 9198; 4095; 14228; 14001; 39561; 80120; 44864; 54960; 95995 -PRKACA PKACA P17612 human GJA1 2697 P17302 GJA1 human S373 459209 RAssRAssRPRPDDL X X -PRKACA PKACA P17612 human H3F3A 3020 P84243 H3-3A human S28 18545302 ATkAARksAPsTGGV Histone X -PRKACA PKACA P17612 human IGFBP1 3484 P08833 IGFBP1 human S126 451658 GsPEsPEstEITEEE X -PRKACA PKACA P17612 human AKAP13 11214 Q12802 AKAP13 human S1565 452184 LsPFRRHsWGPGKNA X X -PRKACA PKACA P17612 human GPLD1 287025 P80109 GPLD1 cow T309 457382 NGFHKNVtAALTKNI X -PRKACA PKACA P17612 human MBP 618684 P02687 MBP cow S109 451768 QGKGrGLsLSRFsWG Myelin_MBP X -PRKACA PKACA P17612 human RAF1 5894 P04049 RAF1 human S259 447741 sQRQRststPNVHMV X 9421; 20011 -PRKACA PKACA P17612 human CARM1 10498 Q86X55 CARM1 human S447 25268707 LIANkRQsYDISIVA X X -PRKACA PKACA P17612 human DAP3 7818 P51398 DAP3 human T186 2226207 DQPLEAstWLkNFkT DAP3 X -PRKACA PKACA P17612 human CPEB3 208922 Q7TN99 Cpeb3 mouse T446 4743577 ssGLssPtRCQNGER X -PRKACA PKACA P17612 human PDE4D iso2 5144 Q08499-2 PDE4D human S54 458388 VHSQRREsFLYRSDS X X -PRKACA PKACA P17612 human RRAD 56437 O88667 Rrad mouse S39 4700224 APPLHRRsMPVDERD X -PRKACA PKACA P17612 human IPO13 116458 Q9JM04 Ipo13 rat S193 15420334 RKGLVRAsLAVECGA Xpo1 X -PRKACA PKACA P17612 human H1E 3008 P10412 H1-4 human S36 456059 GAAkRkAsGPPVsEL X X -PRKACA PKACA P17612 human SREBP-1 78968 P56720 Srebf1 rat S332 458357 IEKRYRssINDKIVE HLH X -PRKACA PKACA P17612 human KCNJ8 25472 Q63664 Kcnj8 rat T234 483977 IQVVKKTtTPEGEVV IRK_C X -PRKACA PKACA P17612 human NLRP3 114548 Q96P20 NLRP3 human S295 57761902 HKIVRKPsRILFLMD NACHT X X -PRKACA PKACA P17612 human GLI3 2737 P10071 GLI3 human S865 15501379 YLSSRRssGISPCFs X X -PRKACA PKACA P17612 human PIN1 5300 Q13526 PIN1 human S16 447772 PGWEkRMsRSSGRVy WW X X -PRKACA PKACA P17612 human TRPA1 8989 O75762 TRPA1 human S428 62873402 CRQGGPGsVNNLLGF Ank_2 X -PRKACA PKACA P17612 human PPP2R5D 21770 Q7TNL5 Ppp2r5d mouse S81 468499 VKKERRQssFPFNLN X -PRKACA PKACA P17612 human GJA1 24392 P08050 Gja1 rat S365 459207 IVDQRPssRAssRAs X X -PRKACA PKACA P17612 human nAChRA4 25590 P09483 Chrna4 rat S472 467263 LIKARSLsVQHVPSS Neur_chan_memb X -PRKACA PKACA P17612 human MYBPC1 iso2 109272 G0YZM8 Mybpc1 mouse S59 21560210 RALERKDsEWsLGES X -PRKACA PKACA P17612 human PKACA 18747 P05132 Prkaca mouse S339 449886 EEEEIRVsINEKCGK X -PRKACA PKACA P17612 human TXA2-R 6915 P21731 TBXA2R human S331 470029 sTRPRsLsLQPQLtQ X -PRKACA PKACA P17612 human APP 351 P05067 APP human S679 480465 DAEFRHDsGYEVHHQ Beta-APP X X -PRKACA PKACA P17612 human TPPP 11076 O94811 TPPP human T92 487538 VIDGRNVtVTDVDIV p25-alpha X -PRKACA PKACA P17612 human STEP 19259 P54830 Ptpn5 mouse S221 448294 GLQERRGsNVSLTLD X 5659 -PRKACA PKACA P17612 human GSK3B 56637 Q9WV60 Gsk3b mouse S9 449111 SGRPRttsFAEsCKP X X 9336; 9331; 9327; 9323; 9322; 9325; 5558; 8566; 79774; 8466; 25462; 14026; 14332; 14310; 14630 -PRKACA PKACA P17612 human HCN4 330953 O70507 Hcn4 mouse S704 15103404 PMMRKKNsILLHKVQ X -PRKACA PKACA P17612 human STAR 25557 P97826 Star rat S56 450440 GQVRRRssLLGSQLE X -PRKACA PKACA P17612 human VDR 7421 P11473 VDR human S182 454433 tPSFSGDsSSSCSDH X -PRKACA PKACA P17612 human 5-LO 240 P09917 ALOX5 human S272 450169 CsLERQLsLEQEVQQ Lipoxygenase X 3748 -PRKACA PKACA P17612 human GLI3 2737 P10071 GLI3 human S849 7998355 NMLNRRDssAStIsS X X -PRKACA PKACA P17612 human DTNB 1838 O60941 DTNB human T424 12203658 GNVtRPPtDLsFNFD X -PRKACA PKACA P17612 human KCNMA1 iso4 16531 Q08460-4 Kcnma1 mouse S701 23013300 GCRRPKMsIYKRMRR X -PRKACA PKACA P17612 human NFL 281348 P02548 NEFL cow S63 2020617 sYsSSSGsLMPsLEs Filament_head X -PRKACA PKACA P17612 human CYP17A1 1586 P05093 CYP17A1 human S258 464643 KEKFRSDsITNMLDT p450 X -PRKACA PKACA P17612 human GFAT 2673 Q06210 GFPT1 human S235 451019 TARTQIGsKFTRWGs X -PRKACA PKACA P17612 human ADRB2 154 P07550 ADRB2 human S261 447908 TGHGLRRssKFcLKE 7tm_1 X -PRKACA PKACA P17612 human SOX9 20682 Q04887 Sox9 mouse S64 451039 EPDLKKEsEEDKFPV Sox_N X -PRKACA PKACA P17612 human TNNI3 511094 P08057 TNNI3 cow S46 450691 KKSKIsAsRKLQLKT X -PRKACA PKACA P17612 human CFTR 1080 P13569 CFTR human S768 455300 LQARRRQsVLNLMtH CFTR_R X X -PRKACA PKACA P17612 human RASGRP2 10235 Q7LDG7 RASGRP2 human S587 10993875 PRPGRrGsRPPEIRE X -PRKACA PKACA P17612 human RIL 30794 P70271 Pdlim4 mouse S119 468635 PAtsRRssVsGIsLE X X -PRKACA PKACA P17612 human CK1A 1452 P48729 CSNK1A1 human S242 11333101 KISEKkMsTPVEVLC Pkinase X -PRKACA PKACA P17612 human SLC4A4 8671 Q9Y6R1 SLC4A4 human S1026 469803 KKKKKKGsLDsDNDD X -PRKACA PKACA P17612 human SNAP-25 6616 P60880 SNAP25 human T29 23939101 ADESLEstRRMLQLV X -PRKACA PKACA P17612 human Tau iso8 4137 P10636-8 MAPT human S316 5204078 VykPVDLskVtskCG Tubulin-binding X -PRKACA PKACA P17612 human ARHGEF2 16800 Q60875 Arhgef2 mouse T114 12473200 sVsLRSKtTTRERPt X -PRKACA PKACA P17612 human DAT 24898 P23977 Slc6a3 rat S7 451136 _MsKsKCsVGPMssV X -PRKACA PKACA P17612 human CCND1 595 P24385 CCND1 human S234 451829 YRLTRFLsRVIkCDP Cyclin_C X -PRKACA PKACA P17612 human Vimentin 7431 P08670 VIM human S72 449026 ssAVrLrssVPGVRL Filament_head X -PRKACA PKACA P17612 human SFRS2 6427 Q01130 SRSF2 human S171 29431801 RSARRsKsksSsVsR X X -PRKACA PKACA P17612 human ARHGAP17 55114 Q68EM7 ARHGAP17 human S702 472376 LsAPRRYsssLsPIQ X -PRKACA PKACA P17612 human HePTP 5778 P35236 PTPN7 human S44 448309 RLQERrGsNVALMLD X X -PRKACA PKACA P17612 human GFAP 2670 P14136 GFAP human S13 449619 ItsAArrsyVSsGEM Filament_head X -PRKACA PKACA P17612 human desmin 1674 P17661 DES human T76 449615 LRAsRLGttRtPssy Filament_head X -PRKACA PKACA P17612 human MYPT1 396020 Q90623 PPP1R12A chicken T850 452075 PREKRRstGVSFWTQ X -PRKACA PKACA P17612 human TXA2-R 6915 P21731 TBXA2R human S324 3061802 RRLQPRLsTRPRsLs X -PRKACA PKACA P17612 human SHIP 16331 Q9ES52 Inpp5d mouse S30 15621800 SRAGKDGsFLVRASE SH2 X -PRKACA PKACA P17612 human IP3R1 25262 P29994 Itpr1 rat S1756 450682 RPSGRREsLTSFGNG X 3760; 8548 -PRKACA PKACA P17612 human Merlin 4771 P35240 NF2 human S518 448282 DTDMKRLsMEIEKEK ERM_C X X 9163; 13281 -PRKACA PKACA P17612 human CACNA1C 100101555 P15381 CACB rabbit S1700 4714250 PEIRRAIsGDLtAEE CAC1F_C X -PRKACA PKACA P17612 human CYP3A4 1576 P08684 CYP3A4 human S116 8084159 GPVGFMksAIsIAED p450 X -PRKACA PKACA P17612 human TXA2-R 6915 P21731 TBXA2R human S329 450989 RLsTRPRsLsLQPQL X -PRKACA PKACA P17612 human RASGRP2 19395 Q9QUG9 Rasgrp2 mouse S586 10993875 PRPGRRSsRPPEIRE X X -PRKACA PKACA P17612 human PIMT 96764 Q96RS0 TGS1 human S656 1881245402 AQRYRLFsRFDDGIk X X -PRKACA PKACA P17612 human perilipin 1 103968 Q8CGN5 Plin1 mouse S517 471365 YsQLRKKs_______ X -PRKACA PKACA P17612 human LC3A 84557 Q9H492 MAP1LC3A human S12 15116600 RPFKQRRsFADRCKE X -PRKACA PKACA P17612 human STAR 6770 P49675 STAR human S195 450442 RCAKRRGsTCVLAGM START X -PRKACA PKACA P17612 human OFD1 8481 O75665 OFD1 human S899 27457630 QREERRQsNLQEVLE X -PRKACA PKACA P17612 human p47phox 653361 P14598 NCF1 human S370 451730 PAVPPRPsADLILNR p47_phox_C X -PRKACA PKACA P17612 human DRP1 114114 O35303 Dnm1l rat S656 483971 VPVARKLsAREQRDC X X 4867; 6319 -PRKACA PKACA P17612 human LXR-alpha 22259 Q9Z0Y9 Nr1h3 mouse S196 469114 SVsPRVssPPQVLPQ X X -PRKACA PKACA P17612 human CDC25B 12531 P30306 Cdc25b mouse S149 7998663 FTIKRFRsLPVRLLE M-inducer_phosp X -PRKACA PKACA P17612 human GFAT iso2 2673 Q06210-2 GFPT1 human S205 451018 AVGTRRGsPLLIGVR X -PRKACA PKACA P17612 human SIK 17691 Q60670 Sik1 mouse T475 15570318 GSTGRRHtLAEVSTH X -PRKACA PKACA P17612 human CASP9 842 P55211 CASP9 human S195 471401 EkLRRRFssLHFMVE Peptidase_C14 X -PRKACA PKACA P17612 human PFKFB3 5209 Q16875 PFKFB3 human S461 448801 NPLMRRNsVtPLAsP X -PRKACA PKACA P17612 human RASGRF1 192213 P28818 Rasgrf1 rat S898 448487 KEIYRRMsLANTGYS X X -PRKACA PKACA P17612 human CDC25B 12531 P30306 Cdc25b mouse S229 470115 AFTQRPSsAPDLMCL M-inducer_phosp X -PRKACA PKACA P17612 human ChREBP 51085 Q9NP71 MLXIPL human S196 451393 KKRLRKPsREDDLLA X -PRKACA PKACA P17612 human PKD1 5310 P98161 PKD1 human S4252 466929 SLQGRRssRAPAGSS X -PRKACA PKACA P17612 human STMN1 3925 P16949 STMN1 human S16 448554 kELEKrAsGQAFELI Stathmin X X 3353 -PRKACA PKACA P17612 human WT1 7490 P19544 WT1 human S393 451121 KTCQRKFsRSDHLKT zf-C2H2 X X -PRKACA PKACA P17612 human PDZK1 5174 Q5T2W1 PDZK1 human S505 456807 MAKERAHstAsHsss X -PRKACA PKACA P17612 human HCN4 330953 O70507 Hcn4 mouse S816 15103409 RHPRRLQsLIPSALG X -PRKACA PKACA P17612 human CACNA1D 29716 P27732 Cacna1d rat T443 6062712 KGYLDWItQAEDIDP X -PRKACA PKACA P17612 human phosducin 20028 Q9QW08 Pdc mouse S71 451205 ERMSRKMsIQEYELI Phosducin X -PRKACA PKACA P17612 human ITGB4 3691 P16144 ITGB4 human S1364 451655 PSGsQRPsVSDDTGC X X -PRKACA PKACA P17612 human SNAPIN 23557 O95295 SNAPIN human S50 448453 HVHAVREsQVELREQ Snapin_Pallidin X -PRKACA PKACA P17612 human TRPV1 7442 Q8NER1 TRPV1 human S502 450016 YFLQRRPsMKTLFVD Ion_trans X -PRKACA PKACA P17612 human TPH1 P09810 Tph1 rat S58 451575 RKSKRRNsEFEIFVD X -PRKACA PKACA P17612 human LRRK2 120892 Q5S007 LRRK2 human S1444 15785707 NIKARAsssPVILVG Roc X -PRKACA PKACA P17612 human NUDE1 iso1 54820 Q9NXR1-1 NDE1 human T131 20609200 LERAKRAtIMSLEDF X X -PRKACA PKACA P17612 human CAPN1 823 P07384 CAPN1 human S418 785120101 GDREsGCsFVLALMQ Calpain_III X -PRKACA PKACA P17612 human Tau iso8 4137 P10636-8 MAPT human S293 449327 NVQskCGsKDNIkHV Tubulin-binding X -PRKACA PKACA P17612 human NDRG1 10397 Q92597 NDRG1 human T366 454246 GtRsRsHtsEGAHLD X -PRKACA PKACA P17612 human Tau 4137 P10636 MAPT human S579 447930 NVKSKIGstENLKHQ Tubulin-binding X -PRKACA PKACA P17612 human PSMD11 69077 Q8BG32 Psmd11 mouse S14 468525 VEFQRAQsLLSTDRE RPN6_N X -PRKACA PKACA P17612 human AKAP12 9590 Q02952 AKAP12 human S627 476343 KKRVRRPsEsDKEDE WSK X -PRKACA PKACA P17612 human MEKK2 26405 Q61083 Map3k2 mouse S153 3216819 AERKKRLsVVGPPNR X X -PRKACA PKACA P17612 human MBP 618684 P02687 MBP cow S131 451769 FGYGGRAsDYKSAHK Myelin_MBP X -PRKACA PKACA P17612 human Tau 4137 P10636 MAPT human S531 447929 GsRsRtPsLPtPPtR X 77348 -PRKACA PKACA P17612 human ABCB1 5243 P08183 ABCB1 human S683 455364 QAQDRKLstKEALDE X -PRKACA PKACA P17612 human BAD 572 Q92934 BAD human S99 447862 PFrGrsRsAPPNLWA Bcl-2_BAD X 9295; 5286; 4366 -PRKACA PKACA P17612 human RPS19 6223 P39019 RPS19 human S59 7113803 WFytrAAsTARHLYL Ribosomal_S19e X -PRKACA PKACA P17612 human DLC1 50768 Q9R0Z9 Dlc1 mouse S550 467752 DIPERRDsGVGAsLt X X -PRKACA PKACA P17612 human TRIM71 636931 Q1PSW8 Trim71 mouse S3 18914372 _____MAsFPETDFQ X -PRKACA PKACA P17612 human AKAP9 10142 Q99996 AKAP9 human S43 456204 QkKKRKTsSsKHDVS X -PRKACA PKACA P17612 human SLC14A2 54302 Q62668 Slc14a2 rat S486 2813501 TVFPRRKsVFHIEWS X -PRKACA PKACA P17612 human En-2 13799 P09066 En2 mouse S267 452011 LTEQRRQsLAQELSL Homeodomain X X -PRKACA PKACA P17612 human AurA 6790 O14965 AURKA human T288 448784 APSsRRttLCGtLDy Pkinase X 3079; 2914; 13464; 8525 -PRKACA PKACA P17612 human INVS 27130 Q9Y283 INVS human T795 1384540900 CAPQKRRtQELrGGR X -PRKACA PKACA P17612 human POLD3 10714 Q15054 POLD3 human S458 3196808 GkANRQVsITGFFQR CDC27 X X -PRKACA PKACA P17612 human PPP1R1A 5502 Q13522 PPP1R1A human T75 471085 PRQRKKMtRItPTMK DARPP-32 X -PRKACA PKACA P17612 human RASGRP2 19395 Q9QUG9 Rasgrp2 mouse S116 468584 QEGNRRHssLIDIES X X -PRKACA PKACA P17612 human Tau 4137 P10636 MAPT human S673 449104 RVQSKIGsLDNITHV Tubulin-binding X -PRKACA PKACA P17612 human NMDAR2B 2904 Q13224 GRIN2B human S1166 481156 sDDFKRDsVsGGGPC NMDAR2_C X -PRKACA PKACA P17612 human SOX9 6662 P48436 SOX9 human S181 456981 YQPRRRKsVKNGQAE X X -PRKACA PKACA P17612 human CACNA1D 29716 P27732 Cacna1d rat T49 6062717 QPNssKQtVLsWQAA X -PRKACA PKACA P17612 human TPI1 iso3 7167 P60174-3 TPI1 human S58 465652 KMNGRKQsLGELIGT TIM X X -PRKACA PKACA P17612 human Kv1.4 3739 P22459 KCNA4 human T601 456509 LKKFRSStSSSLGDK X -PRKACA PKACA P17612 human KCNN2 3781 Q9H2S1 KCNN2 human S135 460691 FEKRKRLsDYALIFG SK_channel X -PRKACA PKACA P17612 human MYPT1 396020 Q90623 PPP1R12A chicken S694 451998 QARQSRRstQGVTLT X -PRKACA PKACA P17612 human VASP 22323 P70460 Vasp mouse S153 448379 EHMERRVsNAGGPPA X 3111; 84519 -PRKACA PKACA P17612 human RYR1 20190 E9PZQ0 Ryr1 mouse S2844 451818 KKKTRkIsQTAQtYD X -PRKACA PKACA P17612 human APOBEC3G 60489 Q9HC16 APOBEC3G human T32 5044101 PILSRRNtVWLCYEV NAD2 X X -PRKACA PKACA P17612 human DLC1 50768 Q9R0Z9 Dlc1 mouse S432 15500000 KELKRRNssSSLSSR X X -PRKACA PKACA P17612 human Titin 84015 XP_008773743 Ttn rat S3897 27842904 LRTEEGKsLsFPLAL X -PRKACA PKACA P17612 human ROMK 24521 P35560 Kcnj1 rat S219 2461201 RVANLRKsLLIGSHI IRK_C X -PRKACA PKACA P17612 human EGR2 13654 P08152 Egr2 mouse S349 1875113000 EGCDRRFsRSDELTR zf-C2H2 X -PRKACA PKACA P17612 human mucolipin 1 57192 Q9GZU1 MCOLN1 human S557 1233701 SGkFRRGsGsACsLL X X -PRKACA PKACA P17612 human THOP1 64517 P24155 Thop1 rat S644 448213 VGMDYRTsILRPGGS Peptidase_M3 X -PRKACA PKACA P17612 human TNNI3 21954 P48787 Tnni3 mouse S24 448424 APVRRRssANyRAYA Troponin-I_N X -PRKACA PKACA P17612 human GPKOW 27238 Q92917 GPKOW human S27 10405008 sFGFtRtsARRRLAD X X -PRKACA PKACA P17612 human GMF-beta 2764 P60983 GMFB human S83 451485 QHDDGRVsyPLCFIF Cofilin_ADF X -PRKACA PKACA P17612 human RAP1GAP 5909 P47736 RAP1GAP human S490 15405645 KsPtRKKsGPFGsRR X X -PRKACA PKACA P17612 human separase 9700 Q14674 ESPL1 human S1501 447668 TDNWRKMsFEILRGs X -PRKACA PKACA P17612 human CDK16 5127 Q00536 CDK16 human S153 453451 sRRLRRVsLsEIGFG X X -PRKACA PKACA P17612 human CYP2E1 1571 P05181 CYP2E1 human S256 23940001 RVkEHHQsLDPNCPR p450 X -PRKACA PKACA P17612 human GRK1 6011 Q15835 GRK1 human S21 456353 AFIAARGsFDGSSSQ X -PRKACA PKACA P17612 human KCNK9 51305 Q9NPC2 KCNK9 human S373 18609100 RLMKRRKsV______ X X -PRKACA PKACA P17612 human CAMKK2 10645 Q96RR4 CAMKK2 human S100 4755871 HLsGRkLsLQERSQG X -PRKACA PKACA P17612 human Tau iso8 4137 P10636-8 MAPT human S409 449132 DtsPRHLsNVsstGs X -PRKACA PKACA P17612 human AVPR2 554 P30518 AVPR2 human S255 2853107 RRGRRTGsPGEGAHV 7tm_1 X -PRKACA PKACA P17612 human CAD 790 P27708 CAD human S1406 451249 GAGGRRLssFVtkGY MGS X X -PRKACA PKACA P17612 human CAPN1 823 P07384 CAPN1 human S256 785120103 GCsIDIssVLDMEAI Peptidase_C2 X -PRKACA PKACA P17612 human CPEB3 208922 Q7TN99 Cpeb3 mouse S299 25734913 PLKKPFssNVIAPPK X -PRKACA PKACA P17612 human GIRK1 3760 P48549 KCNJ3 human S385 4706226 NSKERHNsVECLDGL X X -PRKACA PKACA P17612 human GNMT 25134 P13255 Gnmt rat S10 460706 DSVYRTRsLGVAAEG X -PRKACA PKACA P17612 human GJA1 2697 P17302 GJA1 human S369 459208 RPssRAssRAssRPR X X -PRKACA PKACA P17612 human NKX2-1 25628 P23441 Nkx2-1 rat S337 3081708 DLAHHAAsPAALQGQ X -PRKACA PKACA P17612 human NFkB-p65 5970 Q04206 RELA human S42 25302155 RYkCEGRsAGsIPGE RHD_DNA_bind X -PRKACA PKACA P17612 human nAChRA4 25590 P09483 Chrna4 rat S491 467264 EDGIRCRsRSIQYCV Neur_chan_memb X -PRKACA PKACA P17612 human MYBPC3 4607 Q14896 MYBPC3 human S275 471079 LSAFRRtsLAGGGRR X -PRKACA PKACA P17612 human ARPP-19 10776 P56211 ARPP19 human S104 477874 DLPQRkPsLVAskLA Endosulfine X -PRKACA PKACA P17612 human RRAD 56437 O88667 Rrad mouse S301 4700229 AFRAKsKsCHDLSVL X -PRKACA PKACA P17612 human MBP 618684 P02687 MBP cow S10 456424 QKRPsQRsKYLASAs X -PRKACA PKACA P17612 human GFAP 2670 P14136 GFAP human S8 449618 MERRRItsAArrsyV Filament_head X -PRKACA PKACA P17612 human SHIP 16331 Q9ES52 Inpp5d mouse T1092 15621807 tPRIRsFtCSSSAEG X -PRKACA PKACA P17612 human CA9 768 Q16790 CA9 human T443 21691604 RRQHRRGtKGGVsyR X X -PRKACA PKACA P17612 human DDB1 1642 Q16531 DDB1 human S645 7321234 LRtFRSLstTNVFAC X -PRKACA PKACA P17612 human GSK3A 2931 P49840 GSK3A human S21 448584 sGrARtssFAEPGGG X X 9337; 9316; 9331; 5090; 9327; 8452; 8566 -PRKACA PKACA P17612 human PDE5A 8654 O76074 PDE5A human S102 448178 GTPTRKIsAsEFDRP X -PRKACA PKACA P17612 human CBX3 11335 Q13185 CBX3 human S93 457001 kDGtKRksLsDsEsD X X 2600 -PRKACA PKACA P17612 human PKACA 282322 P00517 PRKACA cow T198 448459 RVKGRTWtLCGTPEY Pkinase X 4781; 5661 -PRKACA PKACA P17612 human WEE1B 381759 Q66JT0 Wee2 mouse S15 456697 QGLNKKLsFSFCEED X -PRKACA PKACA P17612 human SHIP 16331 Q9ES52 Inpp5d mouse S775 15621805 EGENEEGsEGELVVR X -PRKACA PKACA P17612 human CACNA1D 29716 P27732 Cacna1d rat S929 6062718 GsAFFILsKTNPIRV X -PRKACA PKACA P17612 human HSP27 3315 P04792 HSPB1 human S82 448403 RALsRQLssGVsEIr X 2406; 2401; 9709; 11892; 64293 -PRKACA PKACA P17612 human HCN4 330953 O70507 Hcn4 mouse S996 15103410 PsFMAGAsGGASPVA X -PRKACA PKACA P17612 human NFkB-p105 81736 Q63369 Nfkb1 rat S336 449967 FVQLRRKsDLETSEP RHD_dimer X -PRKACA PKACA P17612 human smMLCK 396445 P11799 MYLK chicken S1749 466361 RAIGRLSsMAMISGM X -PRKACA PKACA P17612 human HCN4 330953 O70507 Hcn4 mouse T1056 3827242 QVPQRRGtPPLtPGR X -PRKACA PKACA P17612 human HNF4 alpha 15378 P49698 Hnf4a mouse S143 458369 RIStRRssYEDSsLP X -PRKACA PKACA P17612 human SREBP-1 6720 P36956 SREBF1 human S338 458357 IEkRYRSsINDkIIE HLH X X -PRKACA PKACA P17612 human Kv11.1 3757 Q12809 KCNH2 human T895 4974500 KLsFRRRtDKDTEQP X X -PRKACA PKACA P17612 human nAChRD P02718 CHNRD torpedo S382 3300801 DLKLRRSsSVGYISK Neur_chan_memb X -PRKACA PKACA P17612 human ERM 2119 P41161 ETV5 human S367 451201 PPYQRRGsLQLWQFL X X -PRKACA PKACA P17612 human HCN4 330953 O70507 Hcn4 mouse S1139 15103400 VTLPRKtssGsLPPP X -PRKACA PKACA P17612 human GluR1 50592 P19490 Gria1 rat S863 448566 TSTLPRNsGAGASGG X X 8084 -PRKACA PKACA P17612 human CACNA1D 29716 P27732 Cacna1d rat S46 6062721 PTSQPNssKQtVLsW X -PRKACA PKACA P17612 human FRAT1 10023 Q92837 FRAT1 human S188 471366 RLQQRRGsQPETRTG GSK-3_bind X X -PRKACA PKACA P17612 human HIF1A 3091 Q16665 HIF1A human T700 56589704 VALsQRTtVPEEELN X -PRKACA PKACA P17612 human VASP 7408 P50552 VASP human S239 448380 GAKLRKVsKQEEASG X X 3114; 37565 -PRKACA PKACA P17612 human RAP1B 5908 P61224 RAP1B human S179 451799 PGkARKKsscQLL__ X X -PRKACA PKACA P17612 human HCN4 330953 O70507 Hcn4 mouse S903 15103407 FHKALGGsLSSSDSP X -PRKACA PKACA P17612 human ROMK 56379 O88335 Kcnj1 mouse S25 449605 RQRARLVsKDGRCNI IRK X -PRKACA PKACA P17612 human KIF3A 16568 P28741 Kif3a mouse S689 454304 KMGRRKRsAKPEtVI X -PRKACA PKACA P17612 human RAF1 5894 P04049 RAF1 human S621 447746 PKINRsAsEPsLHRA X -PRKACA PKACA P17612 human smMLCK 100009143 P29294 MYLK rabbit S1005 455821 GLSGRKSsTGSPTsP X X -PRKACA PKACA P17612 human NIPP-1 282319 Q28147 PPP1R8 cow S199 451284 PKRKRKNsRVTFsED X -PRKACA PKACA P17612 human LATS1 16798 Q8BYR2 Lats1 mouse S908 457594 HQRCLAHsLVGTPNY Pkinase X 9157 -PRKACA PKACA P17612 human TPH1 7166 P17752 TPH1 human S58 451575 RKSKRRNsEFEIFVD X -PRKACA PKACA P17612 human PPP2R5D 5528 Q14738 PPP2R5D human S573 457390 KVLLRRksELPQDVy X -PRKACA PKACA P17612 human eNOS 4846 P29474 NOS3 human S615 448656 SYKIRFNsISCSDPL Flavodoxin_1 X -PRKACA PKACA P17612 human SEC14L2 23541 O76054 SEC14L2 human S289 455526 VQISRGSsHQVEyEI X -PRKACA PKACA P17612 human FHIP2B 64760 Q86V87 FHIP2B human S325 40642200 GISWRLPsAPSDEAS RAI16-like X -PRKACA PKACA P17612 human HSP70 3303 P0DMV8 HSPA1B human S418 15403914 TALIkrNstIPTkQT HSP70 X -PRKACA PKACA P17612 human LRRK2 120892 Q5S007 LRRK2 human S910 4725893 LVKKKsNsIsVGEFY X -PRKACA PKACA P17612 human SRI 109552 Q6P069 Sri mouse S178 469979 DsFRRRDsGQQGVVN X -PRKACA PKACA P17612 human CYP2E1 1571 P05181 CYP2E1 human S129 455561 WKDIRRFsLttLRNY p450 X -PRKACA PKACA P17612 human KCNN2 54262 P70604 Kcnn2 rat S465 460687 QAIHQLRsVKMEQRK CaMBD X -PRKACA PKACA P17612 human PIMT 96764 Q96RS0 TGS1 human S851 1881245404 DLIRRPAsET_____ X -PRKACA PKACA P17612 human STMN1 16765 P54227 Stmn1 mouse S63 448557 AAEERRKsHEAEVLK Stathmin X -PRKACA PKACA P17612 human CTNNB1 1499 P35222 CTNNB1 human S179 23096710 AVMVHQLskKEAsRH X -PRKACA PKACA P17612 human CUL5 8065 Q93034 CUL5 human S730 963800 MkMRKKIsNAQLQTE Cullin_Nedd8 X -PRKACA PKACA P17612 human LRP6 4040 O75581 LRP6 human T1548 21009100 yAPsRRMtSVATAkG X -PRKACA PKACA P17612 human UBE3A iso2 7337 Q05086-2 UBE3A human T485 48891100 MYSERRItVLYsLVQ X -PRKACA PKACA P17612 human HSP90B 3326 P08238 HSP90AB1 human T89 18495101 RtLtLVDtGIGMtkA HATPase_c X -PRKACA PKACA P17612 human TVB5 P04213 TVB5 mouse S78 25573800 GYKASRPsQENFSLI V-set X -PRKACA PKACA P17612 human CACNB2 100009277 P54288 CAB2 rabbit S322 2024725 ERSNTRSsLAEVQSE Guanylate_kin X -PRKACA PKACA P17612 human nAChRG P02714 CHRNG torpedo S370 3300800 KPQPRRRsSFGIMIK Neur_chan_memb X -PRKACA PKACA P17612 human BAD 12015 Q61337 Bad mouse S155 447863 GRELRRMsDEFEGsF Bcl-2_BAD X X 9297 -PRKACA PKACA P17612 human GJA1 2697 P17302 GJA1 human S365 459207 IVDQRPssRAssRAs X -PRKACA PKACA P17612 human SHP-2 iso1 5781 Q06124-1 PTPN11 human S189 27458516 GGGERFDsLTDLVEH SH2 X -PRKACA PKACA P17612 human MARK2 2011 Q7KZI7 MARK2 human S409 3245780 NPKQRRFsDQAAGPA X X -PRKACA PKACA P17612 human PIK3CG 5294 P48736 PIK3CG human T1024 20506703 YLALRHHtNLLIILF PI3_PI4_kinase X -PRKACA PKACA P17612 human GLI3 2737 P10071 GLI3 human S1006 15501397 GHGVRRAsDPVRTGS X X -PRKACA PKACA P17612 human SYNE1 64009 Q6ZWR6 Syne1 mouse S1389 30310302 EFSKRTEsIATQAEN X -PRKACA PKACA P17612 human PRKD1 5587 Q15139 PRKD1 human S421 4960330 KHTKRKSstVMKEGW X -PRKACA PKACA P17612 human NFkB-p65 5970 Q04206 RELA human S45 25302163 CEGRsAGsIPGERST RHD_DNA_bind X -PRKACA PKACA P17612 human NHE3 24784 P26433 Slc9a3 rat S605 450900 SLEQRRRsIRDTEDM X -PRKACA PKACA P17612 human KDELR1 10945 P24390 KDELR1 human S209 455669 VLKGKKLsLPA____ X X -PRKACA PKACA P17612 human NOXA1 10811 Q86UR1 NOXA1 human S461 990301 VPAGPRMsGAPGRLP X X -PRKACA PKACA P17612 human CTBP2 1488 P56545 CTBP2 human S164 2089803 REGTRVQsVEQIREV 2-Hacid_dh_C; 2-Hacid_dh X -PRKACA PKACA P17612 human HER2 2064 P04626 ERBB2 human T686 451817 QQKIRKYtMRRLLQE X X 88583 -PRKACA PKACA P17612 human Vimentin 22352 P20152 Vim mouse S51 449416 LRPstsRsLysssPG Filament_head X -PRKACA PKACA P17612 human CYP3A4 1576 P08684 CYP3A4 human S478 5938006 TQIPLKLsLGGLLQP p450 X -PRKACA PKACA P17612 human ULK2 9706 Q8IYT8 ULK2 human S1027 41294001 CSIERRLsALCHSTA DUF3543 X -PRKACA PKACA P17612 human LRP1 4035 Q07954 LRP1 human S4520 450168 GGHGsRHsLAsTDEk X -PRKACA PKACA P17612 human Kv4.2 3751 Q9NZV8 KCND2 human S552 450462 VSGSHQGsIQELSTI X -PRKACA PKACA P17612 human BNIP3 664 Q12983 BNIP3 human T188 41388500 IYIGRRLttststF_ BNIP3 X -PRKACA PKACA P17612 human PKAR2B 5577 P31323 PRKAR2B human S114 452036 NRFTRRAsVCAEAyN X -PRKACA PKACA P17612 human CACNA1D 29716 P27732 Cacna1d rat S1743 6062700 VNSDRREsLQQTNTT CAC1F_C X X -PRKACA PKACA P17612 human GABRB1 14400 P50571 Gabrb1 mouse S410 10296601 QyRKPLssREGFGRG Neur_chan_memb X -PRKACA PKACA P17612 human RHOA 387 P61586 RHOA human S188 449035 ARRGKKKsGCLVL__ X X -PRKACA PKACA P17612 human CTBP1 1487 Q13363 CTBP1 human T144 2089802 LNLYRRAtWLHQALR 2-Hacid_dh_C; 2-Hacid_dh X -PRKACA PKACA P17612 human CRF-R1 iso2 1394 P34998-2 CRHR1 human S301 450262 LMTKLRAsTTSETIQ 7tm_2 X -PRKACA PKACA P17612 human TNNI3 511094 P08057 TNNI3 cow S24 448423 PPPVRRRssANYRAY Troponin-I_N X -PRKACA PKACA P17612 human HSP27 3315 P04792 HSPB1 human S78 448402 PAysRALsRQLssGV X 2405 -PRKACA PKACA P17612 human CACNB2 116600 Q8VGC3 Cacnb2 rat S529 1868239900 KKSQHRSssATHQNH X X -PRKACA PKACA P17612 human CACNA1C iso5 12288 Q0PCR6 Cacna1c mouse S1927 455278 ASLGRRAsFHLECLK CAC1F_C X -PRKACA PKACA P17612 human BAD 572 Q92934 BAD human S75 447860 EIRsRHssyPAGtED Bcl-2_BAD X X 9291; 5284; 9296; 5193; 11865; 94223 -PRKACA PKACA P17612 human NFL 281348 P02548 NEFL cow S42 457402 TARSAYSsYSAPVSS Filament_head X -PRKACA PKACA P17612 human PLM 5348 O00168 FXYD1 human S83 451424 EEGtFRssIRRLstR X X -PRKACA PKACA P17612 human TRPC6 22068 Q61143 Trpc6 mouse T69 470868 RLTHRRQtILREKGR X -PRKACA PKACA P17612 human RAP1B 5908 P61224 RAP1B human S180 22689703 GkARKKsscQLL___ X -PRKACA PKACA P17612 human SCN5A 6331 Q14524 SCN5A human S528 451569 KPRssrGsIFtFRRR Na_trans_cytopl X X -PRKACA PKACA P17612 human profilin 1 5216 P07737 PFN1 human S72 15413723 tLGGQkCsVIRDsLL Profilin X -PRKACA PKACA P17612 human SLC24A6 80024 Q6J4K2 SLC8B1 human S258 50596805 YQRQRRGsLFCPMPV X X -PRKACA PKACA P17612 human GRK2 282682 P21146 GRK2 cow S685 447726 VPLIQRGsANGL___ X -PRKACA PKACA P17612 human USP20 10868 Q9Y2K6 USP20 human S333 7323248 RMKDRKFsWGQQRtN X -PRKACA PKACA P17612 human ABCC9 20928 P70170 Abcc9 mouse T633 483974 FESCKKHtGVQSKPI X -PRKACA PKACA P17612 human Spinophilin 84686 O35274 Ppp1r9b rat S94 448728 SDRGVRLsLPRAssL X X -PRKACA PKACA P17612 human ADRB2 154 P07550 ADRB2 human S262 447909 GHGLRRssKFcLKEH 7tm_1 X -PRKACA PKACA P17612 human TNF-R1 7132 P19438 TNFRSF1A human T411 1868023606 LAtWRRRtPRREAtL Death X -PRKACA PKACA P17612 human eNOS 18127 P70313 Nos3 mouse S1176 447884 TSRIRtQsFsLQERQ X 9571; 9570 -PRKACA PKACA P17612 human PDE4A 5141 P27815 PDE4A human S145 458389 ATSQRREsFLYRSDs X -PRKACA PKACA P17612 human PFKM 100345647 P00511 PFKM rabbit S775 458322 EHISRKRsGEATV__ X -PRKACA PKACA P17612 human CACNA1D 29716 P27732 Cacna1d rat S2152 6062707 AStLLNGsVCPRANG CAC1F_C X -PRKACA PKACA P17612 human NDR1 11329 Q15208 STK38 human S10 22553319 MtGstPCssMsNHtk X -PRKACA PKACA P17612 human PKACA 282322 P00517 PRKACA cow T49 4271878 DQFERIKtLGTGsFG Pkinase X -PRKACA PKACA P17612 human ABCB1 5243 P08183 ABCB1 human S667 455363 SsLIRKRsTRRsVRG X -PRKACA PKACA P17612 human CAMKK1 60341 P97756 Camkk1 rat S74 452115 SLSARKFsLQERPAG X -PRKACA PKACA P17612 human HDAC8 55869 Q9BY41 HDAC8 human S39 450667 AKIPKRAsMVHsLIE Hist_deacetyl X X -PRKACA PKACA P17612 human ITCH 16396 Q8C863 Itch mouse T425 470111 VNHNTRItQWEDPRS WW X -PRKACA PKACA P17612 human MAP2 4133 P11137 MAP2 human S1710 456809 HVTsKCGsLKNIRHR Tubulin-binding X X -PRKACA PKACA P17612 human TNNI3 7137 P19429 TNNI3 human S39 3146608 EPHAKKKskIsAsRK X -PRKACA PKACA P17612 human SNAP-25 6616 P60880 SNAP25 human S187 448668 RIMEKADsNKTRIDE X -PRKACA PKACA P17612 human GJA8 395846 P36381 GJA8 chicken S395 9824606 KASSRARsDDLTV__ X X -PRKACA PKACA P17612 human ABCC9 20928 P70170 Abcc9 mouse S1387 483973 HTLRsRLsIILQDPI ABC_tran X X -PRKACA PKACA P17612 human eNOS 4846 P29474 NOS3 human S1177 447884 TSRIRtQsFsLQERQ X 9571; 9570 -PRKACA PKACA P17612 human GJD2 14617 O54851 Gjd2 mouse S315 471389 PNFGRTQsSDSAYV_ X -PRKACA PKACA P17612 human Survivin 332 O15392 BIRC5 human S20 485776 FLkDHRIstFkNWPF BIR X X -PRKACA PKACA P17612 human Kv7.2 iso4 3785 O43526-4 KCNQ2 human S438 481666 QTVRRsPsADQSLED KCNQ_channel X -PRKACA PKACA P17612 human STIM1 6786 Q13586 STIM1 human T389 37049500 KIKKKRNtLFGtFHV SOAR X -PRKACA PKACA P17612 human UFD1L 7353 Q92890 UFD1 human S229 15428799 ELGFRAFsGsGNRLD X X -PRKACA PKACA P17612 human CREB 1385 P16220 CREB1 human S119 448228 EILsRRPsyRkILND pKID X 9187; 9196; 9198; 4095; 14228; 14001; 39561; 80120; 44864; 54960; 95995 -PRKACA PKACA P17612 human ARHGEF7 114559 O55043 Arhgef7 rat S516 455215 RKPERKPsDEEFAVR RhoGEF67_u2 X X -PRKACA PKACA P17612 human Oct4 5460 Q01860 POU5F1 human S288 22830416 RRQKGKRsssDyAQR X -PRKACA PKACA P17612 human GFAP 2670 P14136 GFAP human T7 449617 _MERRRItsAArrsy Filament_head X -PRKACA PKACA P17612 human KCNN2 3781 Q9H2S1 KCNN2 human S569 460690 sRRRrsssTAPPtSS X X -PRKACA PKACA P17612 human APPL 26060 Q9UKG1 APPL1 human S410 25802100 sFQQRHEsLRPAAGQ X -PRKACA PKACA P17612 human HCN4 330953 O70507 Hcn4 mouse S1142 4699522 PRKtssGsLPPPLSL X -PRKACA PKACA P17612 human Vimentin 280955 P48616 VIM cow S7 455449 _MSTRSVsSSSYRRM Filament_head X -PRKACA PKACA P17612 human CUTL1 1523 P39880 CUX1 human S1215 460700 AYMKRRHssVsDSQP X -PRKACA PKACA P17612 human ABCC9 25560 Q63563 Abcc9 rat S636 41608700 KKHtGVQsKPINRKQ X -PRKACA PKACA P17612 human SEPT7 989 Q16181 SEPTIN7 human T198 56658862 PLIAkADtLTPEECQ Septin X -PRKACA PKACA P17612 human SHIP 16331 Q9ES52 Inpp5d mouse S441 15621804 QGKTRDDsADYIPHD Exo_endo_phos X X -PRKACA PKACA P17612 human DTNB 1838 O60941 DTNB human T11 27100600 ESGNKRktMAEKRQL X -PRKACA PKACA P17612 human RYR2 6262 Q92736 RYR2 human S2031 455603 TIRGRLLsLVEKVTy X X -PRKACA PKACA P17612 human ADAM22 11496 Q9R1V6 Adam22 mouse S855 469109 RFRPRsNsTEtLsPA X -PRKACA PKACA P17612 human PKACA 282322 P00517 PRKACA cow S11 469998 AAAAKKGsEQEsVKE X -PRKACA PKACA P17612 human GIRK4 3762 P48544 KCNJ5 human T199 27523602 QPKKRAEtLMFsNNA X -PRKACA PKACA P17612 human NEDD4L 23327 Q96PU5 NEDD4L human T367 453439 AGRARsstVtGGEEP X -PRKACA PKACA P17612 human CIITA 4261 P33076 CIITA human S834 448443 QELPGRLsFLGtRLT X -PRKACA PKACA P17612 human CK1A 1452 P48729 CSNK1A1 human S218 11333100 LMYFNRTsLPWQGLk Pkinase X -PRKACA PKACA P17612 human TRPM8 79054 Q7Z2W7 TRPM8 human S9 12570903 SFRAARLsMRNRRND X -PRKACA PKACA P17612 human PKD2L1 9033 Q9P0L9 PKD2L1 human S682 394791406 EIEKLGRsIVssPQG X -PRKACA PKACA P17612 human MYBPC3 17868 O70468 Mybpc3 mouse S282 471080 AGAGRRtsDsHEDAG X -PRKACA PKACA P17612 human MFN2 9927 O95140 MFN2 human S442 4746700 AEEIRRLsVLVDDYQ X -PRKACA PKACA P17612 human CACNA1C 12288 Q01815 Cacna1c mouse S1897 455278 ASLGRRAsFHLECLK CAC1F_C X -PRKACA PKACA P17612 human CACNA1D 29716 P27732 Cacna1d rat S1964 4771088 PPSHRRSsFNFECLR CAC1F_C X X -PRKACA PKACA P17612 human KCNK18 332396 Q6VV64 Kcnk18 mouse S264 2712200 RPVERSNsCPELVLG X -PRKACA PKACA P17612 human HNF4 alpha 25735 P22449 Hnf4a rat S143 458369 RISTRRssYEDSSLP X -PRKACA PKACA P17612 human GSK3B 2932 P49841 GSK3B human S9 449111 SGRPRttsFAEsCkP X X 9336; 9331; 9327; 9323; 9322; 9325; 5558; 8566; 79774; 8466; 25462; 14026; 14332; 14310; 14630 -PRKACA PKACA P17612 human CACNA1D 29716 P27732 Cacna1d rat S1788 6062704 HNHHNHNsIGKQVPt CAC1F_C X -PRKACA PKACA P17612 human PAH 5053 P00439 PAH human S16 449074 PGLGRKLsDFGQETS X -PRKACA PKACA P17612 human LXR-alpha 22259 Q9Z0Y9 Nr1h3 mouse S195 479432 TSVsPRVssPPQVLP X X -PRKACA PKACA P17612 human SCN5A 6331 Q14524 SCN5A human S516 4719558 LsLTrGLsRTsMKPR Na_trans_cytopl X -PRKACA PKACA P17612 human PDE4D iso7 5144 Q08499-7 PDE4D human S126 458388 VHSQRREsFLYRSDS X -PRKACA PKACA P17612 human TRPC6 22068 Q61143 Trpc6 mouse S28 22280200 AGTRRNEsQDYLLMD X -PRKACA PKACA P17612 human emerin 2010 P50402 EMD human S49 457523 EtQRRRLsPPsssAA X -PRKACA PKACA P17612 human PDE3B 5140 Q13370 PDE3B human S318 449873 CkIFRRPsLPCIsRE X -PRKACA PKACA P17612 human MYPT1 396020 Q90623 PPP1R12A chicken T695 448587 ARQSRRstQGVTLTD X 5163 -PRKACA PKACA P17612 human MAZ 100008693 O97600 MAZ rabbit S187 449094 ALEKKRKsKGPYICA X -PRKACA PKACA P17612 human HCN4 330953 O70507 Hcn4 mouse S1097 4699507 sPHssGEsVAAFSLY X -PRKACA PKACA P17612 human GRK7 131890 Q8WTQ7 GRK7 human S23 456354 YLQARKPsDCDSKEL X -PRKACA PKACA P17612 human NIPP-1 282319 Q28147 PPP1R8 cow S178 451282 TAHNKRIsTLTIEEG X -PRKACA PKACA P17612 human PLM 5348 O00168 FXYD1 human S88 451425 RssIRRLstRRR___ X X -PRKACA PKACA P17612 human GIRK1 50599 P63251 Kcnj3 rat S401 10769100 DISTKLPsKLQKItG X -PRKACA PKACA P17612 human NFkB-p65 19697 Q04207 Rela mouse S276 447798 SMQLRRPsDRELSEP RHD_dimer X -PRKACA PKACA P17612 human NPM1 18148 Q61937 Npm1 mouse S88 4169620 MsVQPTVsLGGFEIt Nucleoplasmin X -PRKACA PKACA P17612 human K8 25626 Q10758 Krt8 rat S426 13201905 YAGGLSSsYGGLTsP X -PRKACA PKACA P17612 human AID 57379 Q9GZX7 AICDA human T27 471423 WAKGRREtYLCYVVK APOBEC2 X X -PRKACA PKACA P17612 human CETN2 1069 P41208 CETN2 human S170 448199 LRIMkKTsLY_____ X -PRKACA PKACA P17612 human GLI1 2735 P08151 GLI1 human S640 457679 AGVTRRAsDPAQAAD X -PRKACA PKACA P17612 human GLI3 2737 P10071 GLI3 human S907 15501388 TDAsRRSsEASQSDG X X -PRKACA PKACA P17612 human WT1 7490 P19544 WT1 human S365 451117 KDCERRFsRSDQLKR zf-C2H2 X X -PRKACA PKACA P17612 human TGM2 21817 P21981 Tgm2 mouse S216 467223 RDCSRRSsPIyVGRV X -PRKACA PKACA P17612 human HSPB8 26353 Q9UJY1 HSPB8 human S57 2201401 DWALPRLsSAWPGtL X -PRKACA PKACA P17612 human CPEB3 208922 Q7TN99 Cpeb3 mouse S419 54003201 YGRRRGRssLFPFED X X -PRKACA PKACA P17612 human GluR1 2890 P42261 GRIA1 human S863 448566 TStLPRNsGAGASSG X 8084 -PRKACA PKACA P17612 human K8 25626 Q10758 Krt8 rat S9 484004 sVRVTQKsYKMsTSG Keratin_2_head X -PRKACA PKACA P17612 human PDE3B 5140 Q13370 PDE3B human S296 475067 IRPRRRssCVsLGEt X -PRKACA PKACA P17612 human PDE3A 5139 Q14432 PDE3A human S428 456821 IPKRLRRsLPPGLLR X -PRKACA PKACA P17612 human PLM 58971 O08589 Fxyd1 rat S83 451424 EEGtFRSsIRRLstR X -PRKACA PKACA P17612 human smMLCK 396445 P11799 MYLK chicken S1762 455821 GMsGRKAsGssPTsP X -PRKACA PKACA P17612 human HCN4 330953 O70507 Hcn4 mouse S99 15103402 DCRRFRGsLAsLGsR X -PRKACA PKACA P17612 human CCND1 595 P24385 CCND1 human S90 451827 NYLDRFLsLEPVkkS Cyclin_N X -PRKACA PKACA P17612 human SMN 6606 Q16637 SMN1 human S8 4269865 MAMssGGsGGGVPEQ X X -PRKACA PKACA P17612 human PGC-1 alpha 19017 O70343 Ppargc1a mouse S241 13861602 KCASKKKsHTQPQSQ X X -PRKACA PKACA P17612 human MYPT1 116670 Q10728 Ppp1r12a rat S696 451998 QARQSRRstQGVTLT X -PRKACA PKACA P17612 human SHIP 16331 Q9ES52 Inpp5d mouse S260 4778392 PQVPGEAsPITMVAK X -PRKACA PKACA P17612 human Tau iso8 4137 P10636-8 MAPT human S214 447929 GsRsRtPsLPtPPtR X 77348 -PRKACA PKACA P17612 human SHIP 16331 Q9ES52 Inpp5d mouse S162 15621802 APEVTRLsLSETLFQ X -PRKACA PKACA P17612 human CAPN1 823 P07384 CAPN1 human S415 785120100 DDyGDREsGCsFVLA Calpain_III X -PRKACA PKACA P17612 human HCN4 330953 O70507 Hcn4 mouse T1138 15103405 HVTLPRKtssGsLPP X -PRKACA PKACA P17612 human ABCB1 5243 P08183 ABCB1 human S671 455365 RKRsTRRsVRGsQAQ X -PRKACA PKACA P17612 human SOX11 20666 Q7M6Y2 Sox11 mouse S133 1290433400 TDPAAKPsAGQsPDK X X -PRKACA PKACA P17612 human Titin 22138 A2ASS6 Ttn mouse S3991 27842904 LRTEEGKsLsFPLAL X -PRKACA PKACA P17612 human PLM 58971 O08589 Fxyd1 rat S88 451425 RSsIRRLstRRR___ X X -PRKACA PKACA P17612 human GJA1 2697 P17302 GJA1 human S364 450183 AIVDQRPssRAssRA X -PRKACA PKACA P17612 human PTP-PEST 5782 Q05209 PTPN12 human S39 451311 FMRLRRLstKYRTEK X X -PRKACA PKACA P17612 human PDE8A 5151 O60658 PDE8A human S359 18261095 HKDRRKGsLDVkAVA X X -PRKACA PKACA P17612 human Tau iso8 4137 P10636-8 MAPT human S356 449104 rVQskIGsLDNItHV Tubulin-binding X -PRKACA PKACA P17612 human dematin 2039 Q08495 DMTN human S403 450255 NELKKKAsLF_____ VHP X -PRKACA PKACA P17612 human SNAP-25 6616 P60880 SNAP25 human T138 449875 GGFIRRVtNDARENE SNAP-25 X -PRKACA PKACA P17612 human smMLCK 396445 P11799 MYLK chicken S149 17555039 PPVEHRPsIWGESPP X -PRKACA PKACA P17612 human BNIP3 12176 O55003 Bnip3 mouse T181 41388500 IYIGRRLtTSTSTF_ BNIP3 X -PRKACA PKACA P17612 human PKACA 5566 P17612 PRKACA human T198 448459 RVKGRtWtLCGtPEy Pkinase X 4781; 5661 -PRKACA PKACA P17612 human RAF1 5894 P04049 RAF1 human S43 447744 FGyQRRAsDDGKLtD X -PRKACA PKACA P17612 human eNOS 4846 P29474 NOS3 human S633 448637 WRRKRKEssNtDsAG Flavodoxin_1 X -PRKACA PKACA P17612 human MEF2D 17261 Q63943 Mef2d mouse S190 2246701 QPALQRNsVsPGLPQ X X -PRKACA PKACA P17612 human Kv11.1 3757 Q12809 KCNH2 human S283 4696779 CASVRRAssADDIEA X X -PRKACA PKACA P17612 human STAR 101844174 P70114 Star hamster S194 450442 RCAKRRGsTCVLAGI START X -PRKACA PKACA P17612 human DJ-1 11315 Q99497 PARK7 human T154 2566111 EkDGLILtSRGPGTS DJ-1_PfpI X X -PRKACA PKACA P17612 human CACNA1D 29716 P27732 Cacna1d rat T863 6062709 ANsDNKVtIDDYQEE X -PRKACA PKACA P17612 human DISC1 244667 Q811T9 Disc1 mouse S710 18942700 QLQEAGSsPHAEDEE X X -PRKACA PKACA P17612 human HIF1A 3091 Q16665 HIF1A human T455 31887953 LAMsPLPtAEtPkPL X -PRKACA PKACA P17612 human LKB1 6794 Q15831 STK11 human S428 448147 SSkIRRLsACkQQ__ X 3482 -PRKACA PKACA P17612 human DISC1 27185 Q9NRI5 DISC1 human S713 18942700 QLQEARGsLSVEDER X X -PRKACA PKACA P17612 human TRPV5 Q9XSM3 Trpv5 rabbit T709 4710939 WEILRRNtLGHLNLG X X -PRKACA PKACA P17612 human PDE10A iso2 10846 Q9Y233-2 PDE10A human T16 478273 AScFRRLtECFLSPS X X -PRKACA PKACA P17612 human MYBPC1 iso2 109272 G0YZM8 Mybpc1 mouse S62 21560209 ERKDsEWsLGESPAG X -PRKACA PKACA P17612 human DARPP-32 84152 Q9UD71 PPP1R1B human T34 448047 MIrRRRPtPAMLFRL DARPP-32 X 12438 -PRKACA PKACA P17612 human PPP1R3A 100009140 Q00756 RG1 rabbit S67 449321 SSGGRRVsFADNFGF X -PRKACA PKACA P17612 human mGluR5 108071 Q3UVX5 Grm5 mouse S870 25745197 NLWKRrGssGEtLrY X X -PRKACA PKACA P17612 human Lasp-1 3927 Q14847 LASP1 human S146 448836 MEPERRDsQDGssyR X X -PRKACA PKACA P17612 human ETV1 2115 P50549 ETV1 human S191 3059602 HRFRRQLsEPCNSFP ETS_PEA3_N X X -PRKACA PKACA P17612 human CAPN2 824 P17655 CAPN2 human T370 451304 GNWRRGstAGGCRNY Calpain_III X X -PRKACA PKACA P17612 human ROMK iso2 P35560-2 Kcnj1 rat S294 2461200 ATCQVRTsYVPEEVL IRK_C X X -PRKACA PKACA P17612 human TNF-R1 7132 P19438 TNFRSF1A human T417 11077252 RtPRREAtLELLGRV Death X -PRKACA PKACA P17612 human PPP1R16B 282091 Q95N27 PPP1R16B cow S337 486245 SSLsRRTsSAGSRGK X -PRKACA PKACA P17612 human Fyn 2534 P06241 FYN human S21 1983273 LTEERDGsLNQssGy X X -PRKACA PKACA P17612 human GAD67 2571 Q99259 GAD1 human T91 451699 RDARFRRtETDFSNL X -PRKACA PKACA P17612 human phosducin 25343 P20942 Pdc rat S73 451205 ERMSRKMsIQEYELI Phosducin X -PRKACA PKACA P17612 human PDE3B 5140 Q13370 PDE3B human S73 475068 PQQPRRCsPFCRARL X -PRKACA PKACA P17612 human SF2 6426 Q07955 SRSF1 human S119 27106000 yGPPsRRsENRVVVS X X -PRKACA PKACA P17612 human GJA1 24392 P08050 Gja1 rat S368 447813 QRPssRAssRAssRP X X 3511; 52559 -PRKACA PKACA P17612 human Titin 84015 XP_008773743 Ttn rat S3899 29618903 TEEGKsLsFPLALEE X -PRKACA PKACA P17612 human CREB iso1 81646 P15337-1 Creb1 rat S129 450092 QKRREILsRRPsYRk pKID X -PRKACA PKACA P17612 human GLI1 2735 P08151 GLI1 human S560 457678 YTVSRRSsLASPFPP X -PRKACA PKACA P17612 human PGC-1 alpha 19017 O70343 Ppargc1a mouse T256 13861600 HAQAKPTtLSLPLTP X X -PRKACA PKACA P17612 human BAD 572 Q92934 BAD human S118 447863 GRELRRMsDEFVDsF Bcl-2_BAD X 9297 -PRKACA PKACA P17612 human TH 7054 P07101 TH human S40 1876194200 GQGAPGPsLTGSPWP TOH_N X -PRKACA PKACA P17612 human PJA2 9867 O43164 PJA2 human S342 18713700 RHEAkQRsVQRWREA X X -PRKACA PKACA P17612 human SHANK3 59312 Q9JLU4 Shank3 rat S685 3844913 PPPKRAPsTTLTLRS X X -PRKACA PKACA P17612 human Ezrin 7430 P15311 EZR human S66 458400 LkLDKkVsAQEVRkE FERM_N X X -PRKACA PKACA P17612 human Raptor 57521 Q8N122 RPTOR human S791 1868515108 IDKMRRAssYSsLNS X -PRKACA PKACA P17612 human Titin 7273 Q8WZ42 TTN human S4065 2523800 RDLLSKEsLLsGIPE X -PRKACA PKACA P17612 human NR5A2 2494 O00482 NR5A2 human S510 456465 LPEIRAIsMQAEEYL Hormone_recep X -PRKACA PKACA P17612 human Kv7.5 56479 Q9NR82 KCNQ5 human S88 4780184 GKQGARMsLLGKPLS X -PRKACA PKACA P17612 human TPPP 11076 O94811 TPPP human S159 487537 sGVtKAIssPtVSRL p25-alpha X -PRKACA PKACA P17612 human CACNA1D 29716 P27732 Cacna1d rat T1795 6062703 sIGKQVPtSTNANLN CAC1F_C X -PRKACA PKACA P17612 human TFAM 7019 Q00059 TFAM human S55 18016712 SCPKkPVssYLRFsk HMG_box X X -PRKACA PKACA P17612 human HSF1 3297 Q00613 HSF1 human S320 3849409 AsPGRPssVDtLLsP Vert_HS_TF X X -PRKACA PKACA P17612 human PSMD2 5708 Q13200 PSMD2 human S361 487471 ENNrFGGsGsQVDsA X -PRKACA PKACA P17612 human KLHL3 26249 Q9UH77 KLHL3 human S433 36440206 PMNTRRSsVGVGVVE Kelch_1 X X -PRKACA PKACA P17612 human ARHGEF2 16800 Q60875 Arhgef2 mouse S885 451365 PLDPRRRsLPAGDAL X 14143 -PRKACA PKACA P17612 human Titin 7273 Q8WZ42 TTN human S4185 5474103 IQQGAKtsLQEEMDs X -PRKACA PKACA P17612 human PPP1R1A 5502 Q13522 PPP1R1A human S67 447758 LKSTLAMsPRQRKKM DARPP-32 X -PRKACA PKACA P17612 human Vimentin 7431 P08670 VIM human S73 449025 sAVrLrssVPGVRLL Filament_head X -PRKACA PKACA P17612 human SHP-2 iso1 5781 Q06124-1 PTPN11 human T73 40407604 YGGEKFAtLAELVQY SH2 X -PRKACA PKACA P17612 human NCX1 29715 Q01728 Slc8a1 rat T731 18575503 VDKLIKKtNLALVVG X -PRKACA PKACA P17612 human DLX3 1747 O60479 DLX3 human S10 25736077 GSFDRKLsSILTDIS X -PRKACA PKACA P17612 human TRPV4 59341 Q9HBA0 TRPV4 human S824 4777181 LRRDRWssVVPRVVE X -PRKACA PKACA P17612 human PAPD4 167153 Q6PIY7 TENT2 human S116 50785745 LsGERRYsMPPLFHT X -PRKACA PKACA P17612 human TH 25085 P04177 Th rat S153 3302701 LSSVRRVsDDVRSAR X -PRKACA PKACA P17612 human PPP2R5D 21770 Q7TNL5 Ppp2r5d mouse S53 457388 PssNKRPsNStPPPT X -PRKACA PKACA P17612 human PFKFB1 24638 P07953 Pfkfb1 rat S33 456206 VLQRRRGsSIPQFTN 6PF2K X -PRKACA PKACA P17612 human NFkB-p105 18033 P25799 Nfkb1 mouse S326 22771100 VNITKPAsVFVQLRR RHD_dimer X -PRKACA PKACA P17612 human NSFL1C 55968 Q9UNZ2 NSFL1C human S176 468328 AGEkRQHssQDVHVV X -PRKACA PKACA P17612 human RIMS1 iso7 116837 Q99NE5-7 Rims1 mouse S413 450481 ARHERRHsDVALPHT X -PRKACA PKACA P17612 human Stargazin 84347 Q71RJ2 Cacng2 rat T321 451273 NTANRRTtPV_____ X -PRKACA PKACA P17612 human ITPKA 81677 P17105 Itpka rat S119 4763186 LQQPRRLsTSSLSST X X -PRKACA PKACA P17612 human CSF2RB 12983 P26955 Csf2rb mouse S603 448463 LGPPQSHsLPDLPDQ X -PRKACA PKACA P17612 human Spinophilin 84686 O35274 Ppp1r9b rat S177 448727 LLRQERAsLQDRKLD X X -PRKACA PKACA P17612 human VASP 22323 P70460 Vasp mouse S235 448380 GAKLRKVsKQEEASG X 3114; 37565 -PRKACA PKACA P17612 human TFAM 7019 Q00059 TFAM human S61 27530800 VssYLRFskEQLPIF HMG_box X -PRKACA PKACA P17612 human Kv1.1 3736 Q09470 KCNA1 human S446 451079 SDLSRRssStMSKSE X X -PRKACA PKACA P17612 human CACNA1C 775 Q13936 CACNA1C human S1981 455278 ASLGRRAsFHLECLK X -PRKACA PKACA P17612 human PDE3A 5139 Q14432 PDE3A human S312 456900 SKSHRRTsLPCIPRE X X -PRKACA PKACA P17612 human CD44 960 P16070 CD44 human S697 465669 AVEDRkPsGLNGEAs X X -PRKACA PKACA P17612 human RYR2 689560 B0LPN4 Ryr2 rat S2798 448848 yNRTRRIsQTsQVsI X X -PRKACA PKACA P17612 human DUOX1 53905 Q9NRD9 DUOX1 human S1217 6370300 SHHFRRRsFRGFWLT Ferric_reduct X X -PRKACA PKACA P17612 human Myb 396244 P01103 MYB chicken S116 448757 KYGPKRWsVIAKHLK Myb_DNA-binding X X -PRKACA PKACA P17612 human KCNJ8 25472 Q63664 Kcnj8 rat S385 483976 NsLRKRNsMRRNNsM X -PRKACA PKACA P17612 human RARA 5914 P10276 RARA human S219 13373501 NSSEQRVsLDIDLWD X -PRKACA PKACA P17612 human RCAN1 iso2 1827 P53805-2 RCAN1 human S93 25687504 AQTLHIGsSHLAPPN Calcipressin X -PRKACA PKACA P17612 human PHF2 5253 O75151 PHF2 human S757 20936500 NARVKKEsGSSAAGI X X -PRKACA PKACA P17612 human BRF1 677 Q07352 ZFP36L1 human S334 7997096 LPIFsRLsIsDD___ X X -PRKACA PKACA P17612 human DAP3 7818 P51398 DAP3 human S220 2226205 REstEkGsPLGEVVE DAP3 X -PRKACA PKACA P17612 human HSL 3991 Q05469 LIPE human S853 448803 IAEPMRRsVsEAALA X 4139 -PRKACA PKACA P17612 human DACT1 51339 Q9NYF0 DACT1 human S237 18159801 GAVCRSLsTPQFNSL Dapper X -PRKACA PKACA P17612 human Kv4.2 Q63881 Kcnd2 rat S552 450462 VSGsHRGsVQELSTI X -PRKACA PKACA P17612 human ANXA1 301 P04083 ANXA1 human T216 447973 AGERRkGtDVNVFNT Annexin X -PRKACA PKACA P17612 human SMN 6606 Q16637 SMN1 human S4 7446258 ____MAMssGGsGGG X X -PRKACA PKACA P17612 human CFTR 1080 P13569 CFTR human S660 449979 FSAERRNsILTETLH CFTR_R X X -PRKACA PKACA P17612 human RGS14 114705 O08773 Rgs14 rat T494 5862703 GSTGKRQtCDIEGLV X -PRKACA PKACA P17612 human Kv1.2 100009479 NP_001076191 LOC100009479 rabbit S449 1818102 PDLKKSRsASTISKS X X -PRKACA PKACA P17612 human CACNB2 116600 Q8VGC3 Cacnb2 rat S530 451474 KSQHRSssATHQNHR X X -PRKACA PKACA P17612 human Tau iso8 4137 P10636-8 MAPT human T245 487534 sAKsRLQtAPVPMPD Tubulin-binding X -PRKACA PKACA P17612 human PPM1B 5495 O75688 PPM1B human S195 27461503 MIQRVNGsLAVSRAL PP2C X X -PRKACA PKACA P17612 human HIF1A 3091 Q16665 HIF1A human S692 56589702 PRsPNVLsVALsQRT X -PRKACA PKACA P17612 human Tau iso2 4137 P10636-2 MAPT human S267 449104 RVQSKIGsLDNITHV Tubulin-binding X -PRKACA PKACA P17612 human ataxin-1 6310 P54253 ATXN1 human S775 449110 AtRKRRWsAPESRKL X X -PRKACA PKACA P17612 human CAD 790 P27708 CAD human S1859 451247 PPRIhRAsDPGLPAE X X 12662; 67235; 70307 -PRKACA PKACA P17612 human ATP1A1 24211 P06685 Atp1a1 rat S943 451649 ICKTRRNsVFQQGMK Cation_ATPase_C X -PRKACA PKACA P17612 human GJD2 14617 O54851 Gjd2 mouse S306 471388 NKDLPRVsVPNFGRT X -PRKACA PKACA P17612 human Oct7 5454 P20265 POU3F2 human S360 486486 RKRKKRTsIEVSVKG Homeodomain X -PRKACA PKACA P17612 human PSMD11 5717 O00231 PSMD11 human S14 468525 VEFQrAQsLLSTDrE RPN6_N X X -PRKACA PKACA P17612 human GJA1 24392 P08050 Gja1 rat S369 459208 RPssRAssRAssRPR X X -PRKACA PKACA P17612 human PDE3A 5139 Q14432 PDE3A human S438 456984 PGLLRRVsstWtttt X X -PRKACA PKACA P17612 human HLAA 3105 P04439 HLA-A human S337 11418301 VMWRRKSsDRkGGsy MHC_I_C X -PRKACA PKACA P17612 human QSK 23387 Q9Y2K2 SIK3 human T469 480134 YLSMRRHtVGVADPR X -PRKACA PKACA P17612 human KRas iso2 3845 P01116-2 KRAS human S181 459210 GKKKKkKskTkCVIM X -PRKACA PKACA P17612 human MEF2D 17261 Q63943 Mef2d mouse S121 2246700 EDKYRRAsEELDGLF HJURP_C X X -PRKACA PKACA P17612 human PKACA 282322 P00517 PRKACA cow S213 9768110 LAPEIILsKGYNKAV Pkinase X -PRKACA PKACA P17612 human ATP1A1 476 P05023 ATP1A1 human S943 451649 ICKTRRNsVFQQGMk Cation_ATPase_C X -PRKACA PKACA P17612 human NFkB-p65 5970 Q04206 RELA human S276 447798 sMQLRRPsDRELsEP RHD_dimer X X -PRKACA PKACA P17612 human TH 25085 P04177 Th rat S40 448545 RFIGRRQsLIEDARK TOH_N X 2791 -PRKACA PKACA P17612 human CPEB3 208922 Q7TN99 Cpeb3 mouse S443 2658904 QALssGLssPtRCQN X -PRKACA PKACA P17612 human CACNA1C 24239 P22002 Cacna1c rat S1927 455278 ASLGRRAsFHLECLK CAC1F_C X X -PRKACA PKACA P17612 human K8 25626 Q10758 Krt8 rat S417 13201906 SIHTKTTsGYAGGLS X -PRKACA PKACA P17612 human ABCA1 19 O95477 ABCA1 human S2054 455498 GGNkRKLsTAMALIG ABC_tran X -PRKACA PKACA P17612 human TRPA1 8989 O75762 TRPA1 human S86 62873401 MEKITRDsSLEVLHE Ank_2 X -PRKACA PKACA P17612 human ARFGEF1 10565 Q9Y6D6 ARFGEF1 human S883 459627 EIAGkKIsMKETKEL X -PRKACA PKACA P17612 human RYR2 20191 E9Q401 Ryr2 mouse S2807 448848 YNRTRRIsQtsQVsI X X -PRKACA PKACA P17612 human FLNA 2316 P21333 FLNA human S2152 451357 tRRRRAPsVANVGsH Filamin X X 4761 -PRKACA PKACA P17612 human phosducin 25343 P20942 Pdc rat S54 454888 KEILRQMsSPQSRDD Phosducin X -PRKACA PKACA P17612 human ITCH 16396 Q8C863 Itch mouse S411 470110 GWEkRTDsNGRVYFV WW X -PRKACA PKACA P17612 human FOXO1A 2308 Q12778 FOXO1 human S276 1253812002 RAAKKkAsLQSGQEG X X -PRKACA PKACA P17612 human TNNI3 21954 P48787 Tnni3 mouse S23 448423 PAPVRRRssANyRAY Troponin-I_N X -PRKACA PKACA P17612 human CDC37 11140 Q16543 CDC37 human S97 1214257700 QLRkEERsWEQkLEE CDC37_N X X -PRKACA PKACA P17612 human TH iso2 7054 P07101-2 TH human S67 448545 RFIGRRQsLIEDARK TOH_N X 2791 -PRKACA PKACA P17612 human GluR6 54257 P42260 Grik2 rat S715 451343 FMSSRRQsVLVKSNE Lig_chan X -PRKACA PKACA P17612 human NDRG1 10397 Q92597 NDRG1 human S330 452879 LMRsRtAsGssVtsL X 3506; 11899 -PRKACA PKACA P17612 human C/EBP-beta 1051 P17676 CEBPB human S288 452156 NNIAVRKsRDKAKMR bZIP_2 X -PRKACA PKACA P17612 human RGS14 114705 O08773 Rgs14 rat S258 10343403 NSALRREsQGSLNSS X -PRKACA PKACA P17612 human Src 6714 P12931 SRC human S17 448231 DAsQRRRsLEPAENV X X 5473; 12432 -PRKACA PKACA P17612 human RASGRP2 19395 Q9QUG9 Rasgrp2 mouse S554 4781198 ECrRRAQsVsLEGSA X X -PRKACA PKACA P17612 human Merlin 4771 P35240 NF2 human S10 1720901 GAIASRMsFSsLkRK X -PRKACA PKACA P17612 human TPR 7175 P12270 TPR human S2108 34424908 IQMTRrQsVGrGLQL X X -PRKACA PKACA P17612 human ADD1 118 P35611 ADD1 human S726 449829 KKKFRtPsFLKKsKK X -PRKACA PKACA P17612 human IQGAP2 10788 Q13576 IQGAP2 human T716 18964300 EyMHRRQtFIDNTDS X X -PRKACA PKACA P17612 human HCN4 330953 O70507 Hcn4 mouse S1036 15103403 RASGSHGsLLLPPAS X -PRKACA PKACA P17612 human MYBPC3 17868 O70468 Mybpc3 mouse S302 471081 sLLKKRDsFRRDskL X -PRKACA PKACA P17612 human SMN 6606 Q16637 SMN1 human T85 20503415 NKsQKkNtAAsLQQW SMN X -PRKACA PKACA P17612 human TFAM 7019 Q00059 TFAM human S160 27530802 GkPKRPRsAYNVyVA HMG_box_2 X -PRKACA PKACA P17612 human MBP 618684 P02687 MBP cow S54 451832 RGAPKRGsGKDGHHA Myelin_MBP X -PRKACA PKACA P17612 human S6 29304 P62755 Rps6 rat S236 448093 AKRRRLssLRAstsK X 5006; 4856; 4857; 4858; 4851; 4803; 2211; 3945; 3985; 5316; 4854; 8520; 48319; 40643; 9865; 38573; 14733; 27036; 34411; 62016; 62788; 81736; 97935; 99457; 15448 -PRKACA PKACA P17612 human TAL1 6886 P17542 TAL1 human S172 4704529 NRVKRRPsPYEMEIT X X -PRKACA PKACA P17612 human Vimentin 7431 P08670 VIM human S39 451766 ttstrtysLGsALrP Filament_head X 13614 -PRKACA PKACA P17612 human RASGRP2 361714 P0C643 Rasgrp2 rat S116 468584 QEGNRRHsSLIDIES X -PRKACA PKACA P17612 human PKD2 5311 Q13563 PKD2 human S829 4696848 HSSRRRGsISSGVSY X X -PRKACA PKACA P17612 human ADAM22 11496 Q9R1V6 Adam22 mouse S832 469108 NGRPRsNsWQGNMGG X -PRKACA PKACA P17612 human DNAJC5 80331 Q9H3Z4 DNAJC5 human S10 448129 DQRQRsLstsGEsLy X -PRKACA PKACA P17612 human TRPC6 89823 Q99N78 Trpc6 rat T69 470868 RLTHRRQtVLREKGR X -PRKACA PKACA P17612 human CYP3A4 1576 P08684 CYP3A4 human S119 22553300 GFMksAIsIAEDEEW p450 X -PRKACA PKACA P17612 human Moesin 4478 P26038 MSN human T558 447706 LGRDKyKtLRQIRQG ERM_C X 3141; 3726; 32600 -PRKACA PKACA P17612 human HLAA 3105 P04439 HLA-A human S343 11418300 SsDRkGGsytQAAss MHC_I_C X -PRKACA PKACA P17612 human SREBP-1 78968 P56720 Srebf1 rat S331 7996200 AIEKRYRssINDKIV HLH X -PRKACA PKACA P17612 human p47phox 653361 P14598 NCF1 human S328 449404 QDAYRRNsVRFLQQR NECFESHC X -PRKACA PKACA P17612 human GFAT 2673 Q06210 GFPT1 human S205 451018 AVGtRRGsPLLIGVR X -PRKACA PKACA P17612 human DAP3 7818 P51398 DAP3 human S31 2226208 MGTQARQsIAAHLDN X -PRKACA PKACA P17612 human CPEB3 208922 Q7TN99 Cpeb3 mouse S298 25734909 sPLKKPFssNVIAPP X -PRKACA PKACA P17612 human SNAP-25 6616 P60880 SNAP25 human S28 23939100 LADESLEstRRMLQL X -PRKACA PKACA P17612 human ETV1 2115 P50549 ETV1 human S334 3059601 PTYQRRGsLQLWQFL X X -PRKACA PKACA P17612 human KCNN2 3781 Q9H2S1 KCNN2 human S567 460688 SSsRRRrsssTAPPt X X -PRKACA PKACA P17612 human STAR 101844174 P70114 Star hamster S56 450440 SQVRRRssLLGSQLE X -PRKACA PKACA P17612 human MAP2 4133 P11137 MAP2 human S1782 456422 GAEIItQsPGRssVA X X -PRKACA PKACA P17612 human IP3R2 16439 Q9Z329 Itpr2 mouse S937 468039 QMVLSRGsIFPVSVP X X -PRKACA PKACA P17612 human NMDAR2C 24411 Q00961 Grin2c rat S1231 463822 SCTWRRVssLEsEV_ X -PRKACA PKACA P17612 human p53 7157 P04637 TP53 human S378 447534 skkGQstsRHkkLMF X -PRKACA PKACA P17612 human IRS2 384783 P81122 Irs2 mouse S1138 453435 GGRRRHssEtFSsTt X 2385 -PRKACA PKACA P17612 human GCM1 8521 Q9NP62 GCM1 human S269 18788303 LYEKRKLsSSRTYsS X X -PRKACA PKACA P17612 human EMSY 56946 Q7Z589 EMSY human T207 1210942 KPRKRRRtNsssssP X X -PRKACA PKACA P17612 human CAPN1 823 P07384 CAPN1 human S255 785120102 LGCsIDIssVLDMEA Peptidase_C2 X -PRKACA PKACA P17612 human LAMTOR4 389541 Q0VGL1 LAMTOR4 human S67 1868827201 NVPFkRLsVVFGEHT X X -PRKACA PKACA P17612 human DYNLRB1 83658 Q9NP97 DYNLRB1 human S73 27523608 LtFLRIRsKkNEIMV Robl_LC7 X X -PRKACA PKACA P17612 human AMPKA1 105787 Q5EG47 Prkaa1 mouse S184 3195152 DGEFLRtsCGsPNYA Pkinase X X -PRKACA PKACA P17612 human hnRNP I iso1 5725 P26599-1 PTBP1 human S16 450288 AVGtkRGsDELFstC X X -PRKACA PKACA P17612 human SFRS2 6427 Q01130 SRSF2 human S121 6422897 GyGrRSRsPRRRRRs X X -PRKACA PKACA P17612 human ArgBP2 8470 O94875 SORBS2 human S259 467482 DFRKRRKsEPAVGPP X -PRKACA PKACA P17612 human MBP 618684 P02687 MBP cow S160 456582 FKLGGRDsRSGsPMA Myelin_MBP X -PRKACA PKACA P17612 human G-alpha 13 10672 Q14344 GNA13 human T203 448723 ILLARRPtkGIHEYD G-alpha X -PRKACA PKACA P17612 human FOXO1A 56458 Q9R1E0 Foxo1 mouse S150 1253812000 AGQPRKTsSSRRNAW X -PRKACA PKACA P17612 human PRKD1 18760 Q62101 Prkd1 mouse S203 449896 GVRRRRLsNVsLTGL X X -PRKACA PKACA P17612 human ITGA4 3676 P13612 ITGA4 human S1021 469620 QEENRRDsWsyINSk X X -PRKACA PKACA P17612 human PKACA 5566 P17612 PRKACA human S339 449886 EEEEIRVsINEkCGk X X -PRKACA PKACA P17612 human STMN2 84510 P21818 Stmn2 rat S97 455607 AAEGRRKsQEAQVLK Stathmin X -PRKACA PKACA P17612 human SHIP 16331 Q9ES52 Inpp5d mouse S38 15621801 FLVRASEsIPRAYAL SH2 X -PRKACA PKACA P17612 human MYPT1 116670 Q10728 Ppp1r12a rat T697 448587 ARQSRRstQGVTLTD X 5163 -PRKACA PKACA P17612 human SGK1 6446 O00141 SGK1 human T369 448432 DLINKkItPPFNPNV X -PRKACA PKACA P17612 human MYPT1 396020 Q90623 PPP1R12A chicken S849 451999 RPREKRRstGVSFWT X -PRKACA PKACA P17612 human Pyk2 2185 Q14289 PTK2B human S778 2192705 HNVFKRHsMREEDFI X X -PRKACA PKACA P17612 human CYP2E1 1571 P05181 CYP2E1 human T373 23940002 SNLPHEAtRDtIFrG p450 X -PRKACA PKACA P17612 human TH 7054 P07101 TH human S71 448545 RFIGRRQsLIEDARK TOH_N X 2791 -PRKACA PKACA P17612 human PDE11A 50940 Q9HCR9 PDE11A human S162 2243100 RALLRKAssLPPTTA X -PRKACA PKACA P17612 human 5-LO 240 P09917 ALOX5 human S524 452140 GMRGRKSsGFPkSVK Lipoxygenase X X -PRKACA PKACA P17612 human PARP1 142 P09874 PARP1 human S782 3180399 ySLLrGGsDDsskDP PARP_reg X X -PRKACA PKACA P17612 human PIK3R1 5295 P27986 PIK3R1 human S83 471075 yIGRKKIsPPtPKPR X -PRKACA PKACA P17612 human CYP3A4 1576 P08684 CYP3A4 human S134 17547617 kRLRsLLsPtFTsGK p450 X -PRKACA PKACA P17612 human HNF4 alpha 25735 P22449 Hnf4a rat S142 458368 DRISTRRssYEDSSL X -PRKACA PKACA P17612 human TNNI3 29248 P23693 Tnni3 rat S24 448424 APVRRRssANYRAYA Troponin-I_N X 4004 -PRKACA PKACA P17612 human DAP3 7818 P51398 DAP3 human S185 2226206 FDQPLEAstWLkNFk DAP3 X -PRKACA PKACA P17612 human RFC1 89809 D3ZFT1 Rfc1 rat S361 3136107 GSPTKREsVsPEDSE X X -PRKACA PKACA P17612 human STAR 20845 P51557 Star mouse S194 450442 RCTKRRGsTCVLAGM START X -PRKACA PKACA P17612 human MORC2 22880 Q9Y6X9 MORC2 human T582 30982293 LEALQkTtPIRSQAD X -PRKACA PKACA P17612 human KCNJ13 3769 O60928 KCNJ13 human S287 6039503 EICQRRTsYLPSEIM IRK_C X -PRKACA PKACA P17612 human Titin 22138 A2ASS6 Ttn mouse T4046 2523800 QELLSKEtLFPSMPE X -PRKACA PKACA P17612 human CFTR 1080 P13569 CFTR human S795 449982 TAsTRKVsLAPQANL CFTR_R X X -PRKACA PKACA P17612 human GABRB1 14400 P50571 Gabrb1 mouse S409 451812 IQyRKPLssREGFGR Neur_chan_memb X -PRKACA PKACA P17612 human PREX1 57580 Q8TCU6 PREX1 human S436 2526571 KDRRRKLstVPKCFL DEP X X -PRKACA PKACA P17612 human ADRB1 153 P08588 ADRB1 human S312 469625 RAGKRRPsRLVALRE 7tm_1 X -PRKACA PKACA P17612 human RASGRP2 361714 P0C643 Rasgrp2 rat S586 10993875 PRPGRRSsRPPEIRE X -PRKACA PKACA P17612 human CTNNB1 1499 P35222 CTNNB1 human S552 472273 QDtQRRtsMGGtQQQ X 9566; 5651 -PRKACA PKACA P17612 human Oct4 5460 Q01860 POU5F1 human S289 22830418 RQKGKRsssDyAQRE X -PRKACA PKACA P17612 human CDKN2D 1032 P55273 CDKN2D human T141 25256101 RRDARGLtPLELALQ Ank_2 X -PRKACA PKACA P17612 human HIF1A 3091 Q16665 HIF1A human S761 56589708 RVKGCKssEQNGMEQ X -PRKACA PKACA P17612 human HCN4 330953 O70507 Hcn4 mouse S14 8086705 SMRKRLYsLPQQVGA X -PRKACA PKACA P17612 human AID 11628 Q9WVE0 Aicda mouse S38 457604 YVVKRRDsATsCSLD APOBEC2 X -PRKACA PKACA P17612 human RAP1B 327708 P61223 RAP1B cow S180 22689703 GKARKKssCQLL___ X -PRKACA PKACA P17612 human MYBPC3 17868 O70468 Mybpc3 mouse S307 2846505 RDsFRRDskLEAPAE X -PRKACA PKACA P17612 human STMN1 16765 P54227 Stmn1 mouse S16 448554 KELEKRAsGQAFELI Stathmin X 3353 -PRKACA PKACA P17612 human CASP9 842 P55211 CASP9 human S183 448528 GLRTRTGsNIDCEkL Peptidase_C14 X X -PRKACA PKACA P17612 human CUTL1 1523 P39880 CUX1 human S1237 456479 tEysQGAsPQPQHQL X -PRKACA PKACA P17612 human K8 25626 Q10758 Krt8 rat S37 456882 GARIsSSsFsRVGss Keratin_2_head X -PRKACA PKACA P17612 human CTNNB1 1499 P35222 CTNNB1 human T41 447583 GIHsGATtTAPsLsG X 9561; 9565; 4270; 13537; 41334; 60180 -PRKACA PKACA P17612 human MYBPC3 17868 O70468 Mybpc3 mouse S589 1877150002 PDNRIKVsHIGRVHK I-set X -PRKACA PKACA P17612 human FCER1G 2207 P30273 FCER1G human S69 13310016 DGVytGLstRNQEty ITAM X -PRKACA PKACA P17612 human PHF2 5253 O75151 PHF2 human S954 20936501 QKSKKKKsAKRKLTP X X -PRKACA PKACA P17612 human CREM iso2 12916 P27699-2 Crem mouse S84 448412 EILSRRPsYRKILNE pKID X -PRKACA PKACA P17612 human CFTR 1080 P13569 CFTR human S700 449978 FGEKRkNsILNPINs CFTR_R X X -PRKACA PKACA P17612 human SHIP 16331 Q9ES52 Inpp5d mouse T964 4778428 GRGEGPPtPPsQPPL X -PRKACA PKACA P17612 human TRIP10 9322 Q15642 TRIP10 human T225 1868832804 DMDERRAtRLGAGYG X X -PRKACA PKACA P17612 human PKACA 282322 P00517 PRKACA cow S15 9768112 KKGsEQEsVKEFLAK X -PRKACA PKACA P17612 human CACNA1D 29716 P27732 Cacna1d rat S1816 6062701 AAHGKRPsIGDLEHV CAC1F_C X X -PRKACA PKACA P17612 human HDAC4 9759 P56524 HDAC4 human S584 41452201 EPGQRQPsEQELLFR X X -PRKACA PKACA P17612 human AA-NAT 443531 Q29495 AANAT sheep T31 452141 PGRQRRHtLPANEFR X -PRKACA PKACA P17612 human NOLC1 64896 P41777 Nolc1 rat S627 455685 KKGEKRAssPFRRVR X -PRKACA PKACA P17612 human CAMKK1 60341 P97756 Camkk1 rat T108 452083 PRAWRRPtIESHHVA X -PRKACA PKACA P17612 human K8 25626 Q10758 Krt8 rat S34 3179200 sGPGARIsSSsFsRV Keratin_2_head X -PRKACA PKACA P17612 human ICLN 403971 P35521 CLNS1A dog S45 456841 YIAESRLsWLDGSGL Voldacs X -PRKACA PKACA P17612 human hnRNP D0 3184 Q14103 HNRNPD human S87 449337 sNssPRHsEAAtAQr X -PRKACA PKACA P17612 human RGS10 iso1 6001 O43665-1 RGS10 human S168 455907 QTAAkRAsRIyNT__ X X -PRKACA PKACA P17612 human ARPP-19 60336 Q712U5 Arpp19 rat S104 477874 DLPQRKPsLVASkLA Endosulfine X -PRKACA PKACA P17612 human ROMK 24521 P35560 Kcnj1 rat S313 2461200 ATCQVRTsYVPEEVL IRK_C X -PRKACA PKACA P17612 human IP3R1 16438 P11881 Itpr1 mouse S1755 450682 RPSGRREsLtsFGNG X X 3760; 8548 -PRKACA PKACA P17612 human Desmoplakin 1832 P15924 DSP human S2849 451165 RsGsRRGsFDAtGNs X -PRKACA PKACA P17612 human FOXO1A 56458 Q9R1E0 Foxo1 mouse S273 1253812002 RAAKKkAsLQSGQEG X -PRKACA PKACA P17612 human CACNA1D 29716 P27732 Cacna1d rat S52 6062710 ssKQtVLsWQAAIDA X -PRKACA PKACA P17612 human desmin 1674 P17661 DES human S12 449612 ysSSQRVssYRRtFG Filament_head X -PRKACA PKACA P17612 human GMF-beta 2764 P60983 GMFB human T27 451486 KFRFRKEtNNAAIIM Cofilin_ADF X -PRKACA PKACA P17612 human MBP 618684 P02687 MBP cow S7 451831 _AAQKRPsQRsKYLA X -PRKACA PKACA P17612 human ATR 545 Q13535 ATR human S435 477846 sPKRRRLsssLNPsk X X -PRKACA PKACA P17612 human NLRP3 216799 Q8R4B8 Nlrp3 mouse S291 57761902 CKILRKPsRILFLMD NACHT X -PRKACA PKACA P17612 human CDK9 1025 P50750 CDK9 human S347 3681502 APPRRkGsQItQQst X -PRKACA PKACA P17612 human SUN2 25777 Q9UH99 SUN2 human S12 448844 SQRLtRysQGDDDGs X -PRKACA PKACA P17612 human PKACA 282322 P00517 PRKACA cow S339 449886 EEEEIRVsINEKCGK X -PRKACA PKACA P17612 human TAGLN2 8407 P37802 TAGLN2 human S163 468770 kENPRNFsDNQLQEG X -PRKACA PKACA P17612 human HSP90A 3320 P07900 HSP90AA1 human T90 476047 NkQDRtLtIVDtGIG HATPase_c X X -PRKACA PKACA P17612 human AMPKB1 5564 Q9Y478 PRKAB1 human S24 448111 HKtPRRDssGGtKDG X -PRKACA PKACA P17612 human CYP2E1 1571 P05181 CYP2E1 human S145 23940000 MGKQGNEsRIQREAH p450 X -PRKACA PKACA P17612 human PPP2R5D 5528 Q14738 PPP2R5D human S60 457388 PsSNKRPsNstPPPt X -PRKACA PKACA P17612 human QIK 23235 Q9H0K1 SIK2 human S358 487501 DGRQRRPstIAEQTV X -PRKACA PKACA P17612 human NPM1 18148 Q61937 Npm1 mouse S125 459897 AVEEDAEsEDEDEED X -PRKACA PKACA P17612 human SYNE1 64009 Q6ZWR6 Syne1 mouse S732 4694833 TEAHRKLsEPLEVSF X -PRKACA PKACA P17612 human TGM2 7052 P21980 TGM2 human S215 467222 GRDCsRRssPVyVGR X -PRKACA PKACA P17612 human GJA1 24392 P08050 Gja1 rat S373 459209 RAssRAssRPRPDDL X X -PRKACA PKACA P17612 human GFAT2 14584 Q9Z2Z9 Gfpt2 mouse S202 451674 AVATRRGsPLLIGVR GATase_6 X -PRKACA PKACA P17612 human NDUFS4 4724 O43181 NDUFS4 human S173 2103602 WNkRTRVsTK_____ X -PRKACA PKACA P17612 human Tau iso2 4137 P10636-2 MAPT human S156 447929 GSRSRTPsLPTPPTR X 77348 -PRKACA PKACA P17612 human KCNN2 3781 Q9H2S1 KCNN2 human S568 460689 SsRRRrsssTAPPtS X X -PRKACA PKACA P17612 human RASD2 23551 Q96D21 RASD2 human S239 8097548 SPFARRPsVNSDLKY X X -PRKACA PKACA P17612 human STMN2 84510 P21818 Stmn2 rat S50 455606 KQINKRAsGQAFELI Stathmin X -PRKACA PKACA P17612 human smMLCK 4638 Q15746 MYLK human S1773 455821 GLsGRKsstGsPtsP X -PRKACA PKACA P17612 human Src 6714 P12931 SRC human Y419 448234 RLIEDNEytARQGAk PK_Tyr_Ser-Thr X 2101; 6943; 59548; 70926; 78740; 94361; 17320 -PRKACA PKACA P17612 human H2B 615043 P62808 H2BC19 cow S36 449903 RKRsRKEsYSVYVYK Histone X -PRKACA PKACA P17612 human BAD 12015 Q61337 Bad mouse S136 447862 PFRGRsRsAPPNLWA Bcl-2_BAD X 9295; 5286; 4366 -PRKACA PKACA P17612 human SPTBN1 6711 Q01082 SPTBN1 human T2159 471399 NGAtEQRtssKEssP X -PRKACA PKACA P17612 human STXBP5 81022 Q9WU70 Stxbp5 rat S724 459032 GSSSPHNsDDEQKVN X -PRKACA PKACA P17612 human SOX9 20682 Q04887 Sox9 mouse S211 450957 FKALQADsPHSSSGM X -PRKACA PKACA P17612 human NFAT2 4772 O95644 NFATC1 human S294 448863 PHGsPRVsVTDDSWL X X -PRKACA PKACA P17612 human ABCC9 20928 P70170 Abcc9 mouse S1465 483975 RAFVRKSsILIMDEA ABC_tran X -PRKACA PKACA P17612 human ARHGEF6 9459 Q15052 ARHGEF6 human S684 456737 GSSTRkDsIPQVLLP X -PRKACA PKACA P17612 human CYP3A4 1576 P08684 CYP3A4 human S259 22553301 SVKRMKEsRLEDtQK p450 X -PRKACA PKACA P17612 human AMPKA1 105787 Q5EG47 Prkaa1 mouse S508 4274314 RsCQRSDsDAEAQGK X -PRKACA PKACA P17612 human NFkB-p105 18033 P25799 Nfkb1 mouse S335 449967 FVQLRRKsDLETSEP RHD_dimer X -PRKACA PKACA P17612 human Plectin-1 5339 Q15149 PLEC human S4642 3196844 RAGsRrGsFDAtGsG X X -PRKACA PKACA P17612 human Snail1 6615 O95863 SNAI1 human S11 11493500 SFLVRKPsDPNRKPN X -PRKACA PKACA P17612 human PLCB3 5331 Q01970 PLCB3 human S1105 448448 LDRKRHNsIsEAKMR PLC-beta_C X X 2484 -PRKACA PKACA P17612 human AQP5 362 P55064 AQP5 human S156 1233703 STDSRRTsPVGSPAL MIP X -PRKACA PKACA P17612 human eNOS 24600 Q62600 Nos3 rat S614 448656 SYKIRFNsVSCSDPL Flavodoxin_1 X -PRKACA PKACA P17612 human Titin 7273 Q8WZ42 TTN human S4010 27842904 VRIEEGKsLRFPLAL X -PRKACA PKACA P17612 human CACNA1C 100101555 P15381 CACB rabbit S1627 10349704 KKIWKRTsMKLLDQV Ca_chan_IQ X -PRKACA PKACA P17612 human NACA iso2 17938 Q60817 Naca mouse S99 31834914 TRVTIRKsKNILFVI NAC X X -PRKACA PKACA P17612 human HIF1A 3091 Q16665 HIF1A human S760 56589710 KRVKGCKssEQNGME X -PRKACA PKACA P17612 human SHIP 16331 Q9ES52 Inpp5d mouse S977 15621806 PLsPKKFsSSTANRG X -PRKACA PKACA P17612 human PPP1R1C 151242 Q8WVI7 PPP1R1C human T34 2807902 QIRKRRPtPASLVIL DARPP-32 X -PRKACA PKACA P17612 human HDAC5 10014 Q9UQL6 HDAC5 human S279 4788487 KVAERRssPLLRRKD X X -PRKACA PKACA P17612 human DARPP-32 360616 Q6J4I0 Ppp1r1b rat T34 448047 MIRRRRPtPALLFRV DARPP-32 X 12438 -PRKACA PKACA P17612 human GJA8 395846 P36381 GJA8 chicken S387 9824608 VRSLSRLsKASSRAR X -PRKACA PKACA P17612 human CACNA1D 29716 P27732 Cacna1d rat S2165 6062705 NGDMGPIsHRQDYEL CAC1F_C X -PRKACA PKACA P17612 human SFRS2 6427 Q01130 SRSF2 human S128 29431802 sPRRRRRsRsRSRSR X X -PRKACA PKACA P17612 human DDC 1644 P20711 DDC human S193 1883995300 YSSDQAHsSVERAGL X -PRKACA PKACA P17612 human GSK3A 50686 P18265 Gsk3a rat S21 448584 SGRARtssFAEPGGG X X 9337; 9316; 9331; 9327; 8452; 8566 -PRKACA PKACA P17612 human SHIP 16331 Q9ES52 Inpp5d mouse S1114 15621808 SQGKPKAsASSQAPV X -PRKACA PKACA P17612 human STAR 6770 P49675 STAR human S57 450440 NQVRRRssLLGsRLE X -PRKACA PKACA P17612 human TGM2 7052 P21980 TGM2 human S216 467223 RDCsRRssPVyVGRV X -PRKACA PKACA P17612 human PDZK1 65144 Q9JJ40 Pdzk1 rat S509 456807 PARDRTLsAAsHsss X X -PRKACA PKACA P17612 human PPP1R1A P01099 PPP1R1A rabbit S67 447758 LKPSLAMsPRQRKKM DARPP-32 X -PRKACA PKACA P17612 human SREBP-1 iso3 6720 P36956-3 SREBF1 human S314 458357 IEKRYRSsINDKIIE HLH X X -PRKACA PKACA P17612 human AQP5 11830 Q9WTY4 Aqp5 mouse T259 460666 HREERKKtIELTAH_ X -PRKACA PKACA P17612 human SLK 9748 Q9H2G2 SLK human S189 468769 RtIQRRDsFIGtPyW Pkinase X -PRKACA PKACA P17612 human CAMKK1 60341 P97756 Camkk1 rat S458 486077 KSMLRKRsFGNPFEP X -PRKACA PKACA P17612 human K8 25626 Q10758 Krt8 rat S51 13201907 ssssFRGsLGGFGGA Keratin_2_head X -PRKACA PKACA P17612 human RASSF1 iso2 11186 Q9NS23-2 RASSF1 human S203 484000 TsVRRRtsFYLPKDA RA X -PRKACA PKACA P17612 human GFAT iso2 2673 Q06210-2 GFPT1 human S235 1232948 TGkDKkGsCNLsRVD X -PRKACA PKACA P17612 human rabphilin 3A 171039 P47709 Rph3a rat S274 455801 QGLRRANsVQASRPA X -PRKACA PKACA P17612 human p47phox 653361 P14598 NCF1 human S359 451729 EERQtQRsKPQPAVP p47_phox_C X -PRKACA PKACA P17612 human GLI3 2737 P10071 GLI3 human S877 15501382 CFssRRssEASQAEG X X -PRKACA PKACA P17612 human VASP 7408 P50552 VASP human S157 448379 EHIERRVsNAGGPPA X X 3111; 84519 -PRKACA PKACA P17612 human ER-alpha 2099 P03372 ESR1 human S305 448805 IkRSkkNsLALSLtA X X -PRKACA PKACA P17612 human SHIP 16331 Q9ES52 Inpp5d mouse S246 4778386 RLFDQQLsPGLRPRP X -PRKACA PKACA P17612 human SIK 59329 Q9R1U5 Sik1 rat S577 465992 FQEGRRAsDTSLTQG X -PRKACA PKACA P17612 human PARP1 142 P09874 PARP1 human S785 21440500 LrGGsDDsskDPIDV PARP_reg X X -PRKACA PKACA P17612 human ANPA 4881 P16066 NPR1 human S529 447512 RHLRSAGsRLtLsGR X -PRKACA PKACA P17612 human ACADVL 37 P49748 ACADVL human S586 22680600 VVVLSRAsRSLSEGH X X -PRKACA PKACA P17612 human MYBPC3 17868 O70468 Mybpc3 mouse S273 471079 RsAFRRtsLAGAGRR X -PRKACA PKACA P17612 human AQP2 25386 P34080 Aqp2 rat S256 449854 REVRRRQsVELHsPQ X -PRKACA PKACA P17612 human NKD2 85409 Q969F2 NKD2 human S223 3949685 sAHVRRPstDPQPCs X -PRKACA PKACA P17612 human CAD 790 P27708 CAD human H1856 27989100 FHLPPRIhRAsDPGL X -PRKACA PKACA P17612 human Huntingtin 3064 P42858 HTT human S2548 40422837 TRFGRKLsIIRGIVE X X -PRKACA PKACA P17612 human HSP20 126393 O14558 HSPB6 human S16 450706 PSWLRRAsAPLPGLS Crystallin X X 36519 -PRKACA PKACA P17612 human SLC14A2 54302 Q62668 Slc14a2 rat S499 2813500 WSsIRRRsKVFGKSE X -PRKACA PKACA P17612 human CREB 12912 Q01147 Creb1 mouse S119 448228 EILsRRPsyRkILND pKID X 9187; 9196; 9198; 4095; 14228; 14001; 39561; 80120; 44864; 54960; 95995 -PRKACA PKACA P17612 human NETO2 307757 C6K2K4 Neto2 rat S409 4752528 SLREKEIsADLADLS X -PRKACA PKACA P17612 human NDUFS4 Q02375 NDUFS4 cow S173 2103602 WNKRTRVsTK_____ X -PRKACA PKACA P17612 human PAK6 56924 Q9NQU5 PAK6 human S113 5208141 TSRRRAQsLGLLGDE X -PRKACA PKACA P17612 human RXRA 6256 P19793 RXRA human S27 3188103 tsPTGRGsMAAPsLH Nuc_recep-AF1 X X -PRKACA PKACA P17612 human TH iso3 7054 P07101-3 TH human S40 448545 RFIGRRQsLIEDARK TOH_N X X 2791 -PRKACA PKACA P17612 human SLC26A4 5172 O43511 SLC26A4 human T717 22561300 DDNIRKDtFFLTVHD STAS X -PRKACA PKACA P17612 human SHIP 16331 Q9ES52 Inpp5d mouse S935 4778416 LHGKsTLsPDQQLtA X -PRKACA PKACA P17612 human PKD2L1 9033 Q9P0L9 PKD2L1 human S686 394791407 LGRsIVssPQGKSGP X -PRKACA PKACA P17612 human GJD2 14617 O54851 Gjd2 mouse S110 471386 KQRERRYsTVFLALD Connexin X -PRKACA PKACA P17612 human ROMK 24521 P35560 Kcnj1 rat S44 449605 RQRARLVsKEGRCNI IRK X -PRKACA PKACA P17612 human CFTR 1080 P13569 CFTR human S813 449983 DIYsRRLsQEtGLEI CFTR_R X X -PRKACA PKACA P17612 human nAChRA4 25590 P09483 Chrna4 rat S365 467262 LLFMKRPsVVKDNCR Neur_chan_memb X -PRKACA PKACA P17612 human GATA3 2625 P23771 GATA3 human S308 456464 IKPkRRLsAARRAGT X -PRKACA PKACA P17612 human TPPP 11076 O94811 TPPP human S32 456613 DRAAKRLsLEsEGAG X -PRKACA PKACA P17612 human AKAP13 11214 Q12802 AKAP13 human S2733 455336 sVsPKRNsISRTHKD X X -PRKACA PKACA P17612 human SUN2 25777 Q9UH99 SUN2 human S116 448846 GsEssRAsGLVGRKA X -PRKACA PKACA P17612 human CDK16 5127 Q00536 CDK16 human S12 453448 KKIKRQLsMtLRGGr X -PRKACA PKACA P17612 human KCNJ2 3759 P63252 KCNJ2 human S425 10892807 PRPLRREsEI_____ X -PRKACA PKACA P17612 human KCNN4 65206 Q9QYW1 Kcnn4 rat S332 452145 KHtRRKDsRAARRHQ CaMBD X -PRKACA PKACA P17612 human HCN4 330953 O70507 Hcn4 mouse S117 15103408 sGGAGGGsSLGHLHD X -PRKACA PKACA P17612 human ARHGEF7 114559 O55043 Arhgef7 rat T526 455216 EFAVRKStAALEEDA RhoGEF67_u2 X X -PRKACA PKACA P17612 human 5-LO 240 P09917 ALOX5 human S448 33670304 MKDLtyAsLCFPEAI Lipoxygenase X -PRKACA PKACA P17612 human TNNI3 7137 P19429 TNNI3 human S24 448424 APIRRRssNyRAyAt Troponin-I_N X X 4004 -PRKACA PKACA P17612 human GABBR2 83633 O88871 Gabbr2 rat S892 450809 EHIQRRLsLQLPILH X -PRKACA PKACA P17612 human SUFU 51684 Q9UMX1 SUFU human S346 4786848 RAPsRkDsLEsDSst SUFU_C X -PRKACA PKACA P17612 human IMMT 10989 Q16891 IMMT human S528 55571502 ELQFRRLsQEQVDNF Mitofilin X X -PRKACA PKACA P17612 human AQP4 361 P55087 AQP4 human S276 465556 AAQQTKGsyMEVEDN X -PRKACA PKACA P17612 human ABCC8 Q09427 ABCC8 hamster S1447 22634903 LDPEKKCsDSTLWEA ABC_tran X X -PRKACA PKACA P17612 human TRPM8 79054 Q7Z2W7 TRPM8 human T17 12570902 MRNRRNDtLDSTRTL X -PRKACA PKACA P17612 human MBP 618684 P02687 MBP cow S114 451753 GLsLSRFsWGAEGQK Myelin_MBP X -PRKACA PKACA P17612 human SFRS2 6427 Q01130 SRSF2 human S130 29431800 RRRRRsRsRSRSRSR X X -PRKACA PKACA P17612 human RYR2 6262 Q92736 RYR2 human S2808 448848 YNRTRRIsQTSQVsV X -PRKACA PKACA P17612 human 5-LO 240 P09917 ALOX5 human S671 33670305 sPDRIPNsVAI____ X -PRKACA PKACA P17612 human Tau iso8 4137 P10636-8 MAPT human S416 454127 sNVsstGsIDMVDsP X 15013; 61160 -PRKACA PKACA P17612 human IGFBP1 3484 P08833 IGFBP1 human S194 451660 LAKAQETsGEEIsKF Thyroglobulin_1 X -PRKACA PKACA P17612 human MC4R 4160 P32245 MC4R human T312 449101 RSQELRKtFKEIICC X -PRKACA PKACA P17612 human KCNMA1 iso2 16531 Q08460-2 Kcnma1 mouse S899 469989 HGMLRQPsITTGVNI X -PRKACA PKACA P17612 human GPR15 2838 P49685 GPR15 human S357 125971702 FARRRKRsVsL____ X X -PRKACA PKACA P17612 human CEACAM1 634 P13688 CEACAM1 human S472 1875094100 DLTEHKPsVSNHTQD X -PRKACA PKACA P17612 human KCNK3 3777 O14649 KCNK3 human S393 2840504 GLMKRRssV______ X X -PRKACA PKACA P17612 human calpastatin 831 P20810 CAST human S133 7320476 DKKKEKKsLtPAVPV Calpain_inhib X -PRKACA PKACA P17612 human RFC1 89809 D3ZFT1 Rfc1 rat S245 468617 TKKARKDsEEGESFs X X -PRKACA PKACA P17612 human Kv7.1 3784 P51787 KCNQ1 human S27 2999203 LPGARRGsAGLAKKC X -PRKACA PKACA P17612 human E2F1 1869 Q01094 E2F1 human S235 1870773100 TTQLRLLsEDTDSQR E2F_CC-MB X -PRKACA PKACA P17612 human Tau iso8 4137 P10636-8 MAPT human S305 487457 kHVPGGGsVQIVykP Tubulin-binding X -PRKACA PKACA P17612 human TACC3 10460 Q9Y6A5 TACC3 human S558 474537 ESALRKQsLyLkFDP X 8842; 5645 -PRKACA PKACA P17612 human LXR-alpha 22259 Q9Z0Y9 Nr1h3 mouse T290 479433 DQIALLKtsAIEVML Hormone_recep X X -PRKACA PKACA P17612 human CPEB3 208922 Q7TN99 Cpeb3 mouse S291 25288000 PsPLNPIsPLKKPFs X -PRKACA PKACA P17612 human CASK 29647 Q62915 Cask rat T724 12568401 LPAFKRKtLVLLGAH Guanylate_kin X X -PRKACA PKACA P17612 human GYS1 100008660 P13834 GYS1 rabbit S8 449898 MPLSRTLsVSsLPGL X -PRKACA PKACA P17612 human CACNA1D 29716 P27732 Cacna1d rat S1703 6062702 PEIRRAIsCDLQDDE CAC1F_C X -PRKACA PKACA P17612 human CEACAM1 634 P13688 CEACAM1 human S512 29576348 QPTsAsPsLTATEII X -PRKACA PKACA P17612 human IRE1 78943 Q9EQY0 Ern1 mouse S724 7161100 KLAVGRHsFSRRsGV Pkinase X -PRKACA PKACA P17612 human ROMK iso2 P35560-2 Kcnj1 rat S25 449605 RQRARLVsKEGRCNI IRK X X -Grk3 GRK3 Q3UYH7 mouse SMO 319757 P56726 Smo mouse T597 1872776116 ELSFsMHtVsHDGPV X -Grk3 GRK3 Q3UYH7 mouse SMO 319757 P56726 Smo mouse S642 1872776120 AILPQDVsVtPVAtP X -Grk3 GRK3 Q3UYH7 mouse KOR-1 18387 P33534 Oprk1 mouse T357 52467201 MRMERQstNRVRNtV X -Grk3 GRK3 Q3UYH7 mouse SMO 319757 P56726 Smo mouse S599 1872776118 SFsMHtVsHDGPVAG X -Grk3 GRK3 Q3UYH7 mouse MOR-1 18390 P42866 Oprm1 mouse T376 20727901 NtREHPstANtVDRT X -Grk3 GRK3 Q3UYH7 mouse KOR-1 18387 P33534 Oprk1 mouse S356 52467200 KMRMERQstNRVRNt X -Grk3 GRK3 Q3UYH7 mouse SMO 319757 P56726 Smo mouse S560 1872776110 WCRLTGHsDDEPKRI X -Grk3 GRK3 Q3UYH7 mouse SMO 319757 P56726 Smo mouse S594 1872776114 PGQELSFsMHtVsHD X -Grk3 GRK3 Q3UYH7 mouse SMO 319757 P56726 Smo mouse T644 1872776122 LPQDVsVtPVAtPVP X -Grk3 GRK3 Q3UYH7 mouse MOR-1 18390 P42866 Oprm1 mouse T370 447785 sARIRQNtREHPstA X -Grk3 GRK3 Q3UYH7 mouse MOR-1 18390 P42866 Oprm1 mouse S375 447784 QNtREHPstANtVDR X 3451 -Grk3 GRK3 Q3UYH7 mouse SMO 319757 P56726 Smo mouse T648 1872776124 VsVtPVAtPVPPEEQ X -Grk3 GRK3 Q3UYH7 mouse MOR-1 18390 P42866 Oprm1 mouse T379 20727900 EHPstANtVDRTNHQ X -Mapk7 ERK5 Q9WVS8 mouse ERK5 23939 Q9WVS8 Mapk7 mouse S760 14561007 PQDGQADsASLsAsL X X -Mapk7 ERK5 Q9WVS8 mouse ERK5 23939 Q9WVS8 Mapk7 mouse T723 455520 LPPVFsGtPKGSGAG X X -Mapk7 ERK5 Q9WVS8 mouse ERK5 23939 Q9WVS8 Mapk7 mouse S764 14561006 QADsASLsAsLLADW X X -Mapk7 ERK5 Q9WVS8 mouse NFAT3 73181 Q8K120 Nfatc4 mouse S170 448860 GGAFFsPsPGSSSLS X -Mapk7 ERK5 Q9WVS8 mouse ERK5 23939 Q9WVS8 Mapk7 mouse S766 14561005 DsASLsAsLLADWLE X X -Mapk7 ERK5 Q9WVS8 mouse NFAT3 73181 Q8K120 Nfatc4 mouse S168 448859 QGGGAFFsPsPGSSS X -Mark1 MARK1 O08678 rat Tau iso8 4137 P10636-8 MAPT human S262 447930 NVKskIGstENLkHQ Tubulin-binding X -Mark1 MARK1 O08678 rat Tau iso8 4137 P10636-8 MAPT human S324 449328 kVtskCGsLGNIHHk Tubulin-binding X -Mark1 MARK1 O08678 rat Tau iso8 4137 P10636-8 MAPT human S293 449327 NVQskCGsKDNIkHV Tubulin-binding X -Mark1 MARK1 O08678 rat Tau iso8 4137 P10636-8 MAPT human S356 449104 rVQskIGsLDNItHV Tubulin-binding X -Mark1 MARK1 O08678 rat Tau 29477 P19332 Mapt rat S573 447930 NVRSKIGsTENLKHQ Tubulin-binding X -ALDOB ALDOB P79226 rabbit ALDOB 100328925 P79226 ALDOB rabbit Y362 451309 QSLFTASyTY_____ Glycolytic X -MAPK3 ERK1 P27361 human BRAF 673 P15056 BRAF human T401 452246 sTtGLsAtPPAsLPG X X -MAPK3 ERK1 P27361 human Tau iso8 4137 P10636-8 MAPT human T231 449079 KKVAVVRtPPKsPss X 20473; 71429 -MAPK3 ERK1 P27361 human WTAP 9589 Q15007 WTAP human S341 3196721 AGYESVDsPtGsENs X -MAPK3 ERK1 P27361 human CRYAB 25420 P23928 Cryab rat S45 448748 FSTATSLsPFYLRPP Crystallin X -MAPK3 ERK1 P27361 human DUSP6 1848 Q16828 DUSP6 human S174 5938001 LGGLRISsDSSsDIE X -MAPK3 ERK1 P27361 human HNF4 alpha 3172 P41235 HNF4A human S148 26419226 RssyEDssLPsINAL X -MAPK3 ERK1 P27361 human TIF1A 54700 Q9NYV6 RRN3 human S633 448838 SFDTHFRsPssSVGs X -MAPK3 ERK1 P27361 human TH iso4 7054 P07101-4 TH human S35 448544 AIMVRGQsPRFIGRR TOH_N X -MAPK3 ERK1 P27361 human GATA1 14460 P17679 Gata1 mouse S26 451232 VDSALVSsPSDSTGF X -MAPK3 ERK1 P27361 human NUP153 9972 P49790 NUP153 human T388 3191107 VyFkPsLtPsGEFRK Nup153 X X -MAPK3 ERK1 P27361 human RAF1 5894 P04049 RAF1 human S301 455219 sssPNNLsPtGWsQP X X 9431 -MAPK3 ERK1 P27361 human ATF-2 1386 P15336 ATF2 human T69 448224 sVIVADQtPtPtRFL X 9225; 94125; 40749; 61584; 44167 -MAPK3 ERK1 P27361 human PXN iso2 5829 P49023-2 PXN human S83 451113 FIHQQPQsssPVyGs Paxillin X -MAPK3 ERK1 P27361 human p90RSK 81771 Q63531 Rps6ka1 rat T359 447992 DTEFTSRtPRDsPGI Pkinase_C X 9344 -MAPK3 ERK1 P27361 human STAT1 6772 P42224 STAT1 human S727 447753 TDNLLPMsPEEFDEV STAT1_TAZ2bind X 9177; 8826; 62390 -MAPK3 ERK1 P27361 human KLC1 171041 P37285 Klc1 rat S460 477826 YKACKVDsPTVTTTL X -MAPK3 ERK1 P27361 human Mnk1 8569 Q9BUB5 MKNK1 human T385 447623 APEKGLPtPQVLQRN X -MAPK3 ERK1 P27361 human Tau iso8 4137 P10636-8 MAPT human S199 447927 GDRsGyssPGsPGtP X X 29957 -MAPK3 ERK1 P27361 human FGFR2 2263 P21802 FGFR2 human S780 34500854 SQPLEQYsPsYPDTR X X -MAPK3 ERK1 P27361 human SHARPIN 81858 Q9H0F6 SHARPIN human S146 31883820 ACPVsLPsPPEAStL X X -MAPK3 ERK1 P27361 human HSPB8 26353 Q9UJY1 HSPB8 human S24 2201402 RRDPFRDsPLsSRLL X -MAPK3 ERK1 P27361 human TMEM55B 219024 Q3TWL2 Pip4p1 mouse S169 3204510 PVHPGPLsPEPQPMG Tmemb_55A X -MAPK3 ERK1 P27361 human p47phox 653361 P14598 NCF1 human S348 451728 PGPQsPGsPLEEERQ X -MAPK3 ERK1 P27361 human BVR 644 P53004 BLVRA human S230 478716 LKRNRyLsFHFksGs Biliv-reduc_cat X -MAPK3 ERK1 P27361 human NPAS4 225872 Q8BGD7 Npas4 mouse S580 1871095702 KLPPsPSsPGNGDCT X -MAPK3 ERK1 P27361 human TH iso2 7054 P07101-2 TH human S58 448544 SYTPTPRsPRFIGRR TOH_N X -MAPK3 ERK1 P27361 human SPHK1 8877 Q9NYA1 SPHK1 human S225 460682 VGSKTPAsPVVVQQG X -MAPK3 ERK1 P27361 human ATF-2 1386 P15336 ATF2 human T71 448225 IVADQtPtPtRFLkN X X 9225; 9221; 5112; 94125; 13850; 40749; 15411; 24329; 61584; 27934; 92109; 20534; 35858 -MAPK3 ERK1 P27361 human GRASP55 26003 Q9H8Y8 GORASP2 human T222 470124 LPGQMAGtPItPLKD X -MAPK3 ERK1 P27361 human TACE 6868 P78536 ADAM17 human T735 449804 kPFPAPQtPGRLQPA X X -MAPK3 ERK1 P27361 human NSMF 117536 Q9EPI6 Nsmf rat S180 27713502 AKLVPGPsPRAFGLE X -MAPK3 ERK1 P27361 human REST 5978 Q13127 REST human S861 36320700 sVsTEDLsPPsPPLP X -MAPK3 ERK1 P27361 human TOB1 10140 P50616 TOB1 human S154 455536 SSVSSsPsPPFGHSA X X -MAPK3 ERK1 P27361 human TSC2 7249 P49815 TSC2 human S664 455575 KkTSGPLsPPTGPPG Tuberin X 40729 -MAPK3 ERK1 P27361 human Bcl-2 596 P10415 BCL2 human T74 448632 ARtsPLQtPAAPGAA X -MAPK3 ERK1 P27361 human PPAR-gamma 19016 P37238 Pparg mouse S133 38507801 PHEEPSNsLMAIECR X -MAPK3 ERK1 P27361 human NPAS4 225872 Q8BGD7 Npas4 mouse T427 1869686800 LVCTPPYtPHQPGGC X -MAPK3 ERK1 P27361 human ASL 435 P04424 ASL human S417 1880040200 LQELQTIsPLFSGDV X -MAPK3 ERK1 P27361 human AML3 860 Q13950 RUNX2 human S312 10892802 SYLSQMTsPsIHSTT X X -MAPK3 ERK1 P27361 human WAVE2 10163 Q9Y6W5 WASF2 human S343 18715501 PPPVGFGsPGtPPPP X -MAPK3 ERK1 P27361 human PDE6G 281977 P04972 PDE6G cow T22 449334 RVMGGPVtPRKGPPK PDE6_gamma X -MAPK3 ERK1 P27361 human PXN iso2 5829 P49023-2 PXN human S126 450227 sFPNKQKsAEPsPtV Paxillin X -MAPK3 ERK1 P27361 human ELK4 2005 P28324 ELK4 human S387 4317601 LsPVAPLsPARLQGA X X -MAPK3 ERK1 P27361 human MITF iso9 4286 O75030-9 MITF human S73 450264 PGSSAPNsPMAMLTL MITF_TFEB_C_3_N X -MAPK3 ERK1 P27361 human SMAD2 Q1W668 SMAD2 cow S245 448794 NQSMDTGsPAELsPT X -MAPK3 ERK1 P27361 human MTMR2 8898 Q13614 MTMR2 human S58 3195800 StSADNFsPDLRVLR X X -MAPK3 ERK1 P27361 human GAB2 14389 Q9Z1S8 Gab2 mouse S612 454021 ALDFQPGsPsPHRKP X X -MAPK3 ERK1 P27361 human TORC3 64784 Q6UUV7 CRTC3 human S391 3203130 RRRQPPVsPLtLsPG X -MAPK3 ERK1 P27361 human DRP1 74006 Q8K1M6 Dnm1l mouse S622 454690 PIPIMPAsPQKGHAV X 3455; 4494; 63940 -MAPK3 ERK1 P27361 human WTAP 9589 Q15007 WTAP human S306 453808 tEDDFPssPGNGNKs X -MAPK3 ERK1 P27361 human Tel 2120 P41212 ETV6 human S257 451378 ESHPKPSsPRQESTR X X -MAPK3 ERK1 P27361 human ELK1 2002 P19419 ELK1 human S389 449757 LsPIAPRsPAKLSFQ X X -MAPK3 ERK1 P27361 human LYL1 4066 P12980 LYL1 human S36 15624701 APPPKPAsPGPPQVE X -MAPK3 ERK1 P27361 human ISX 91464 Q2M1V0 ISX human S183 1874101900 RRLAPPTsCCPSAQD X X -MAPK3 ERK1 P27361 human NIPA 232679 Q80YV2 Zc3hc1 mouse S353 449745 PIVsRtRsWEsssPV X -MAPK3 ERK1 P27361 human SP1 6667 P08047 SP1 human S59 452233 GGQEsQPsPLALLAA X X -MAPK3 ERK1 P27361 human RAGE 11596 Q62151 Ager mouse S376 4731271 EERKAPEsQEDEEER X -MAPK3 ERK1 P27361 human DUSP5 1847 Q16690 DUSP5 human S346 10206800 IGHLQTLsPDMQGAY X -MAPK3 ERK1 P27361 human CASP9 842 P55211 CASP9 human T125 449563 PEVLRPEtPRPVDIG X -MAPK3 ERK1 P27361 human DUSP6 1848 Q16828 DUSP6 human S159 455265 DGSCSSSsPPLPVLG X -MAPK3 ERK1 P27361 human LAT iso2 27040 O43561-2 LAT human T155 451994 PSAPALStPGIRDSA LAT X X -MAPK3 ERK1 P27361 human SRC-1 8648 Q15788 NCOA1 human T1179 449063 NYGTNPGtPPASTsP DUF1518 X -MAPK3 ERK1 P27361 human ER-alpha 2099 P03372 ESR1 human S104 448099 FPPLNsVsPsPLMLL Oest_recep X -MAPK3 ERK1 P27361 human AML3 860 Q13950 RUNX2 human S294 10892804 DPRQAQSsPPWSYDQ X X -MAPK3 ERK1 P27361 human PSD-93 64053 Q63622 Dlg2 rat S323 472024 KTSLPPIsPGRysPI PDZ_assoc X -MAPK3 ERK1 P27361 human RHOA 387 P61586 RHOA human S88 53332703 LMCFSIDsPDSLENI Ras X X -MAPK3 ERK1 P27361 human smMLCK 4638 Q15746 MYLK human T978 15423395 VPPPKPAtPDFRSVL X -MAPK3 ERK1 P27361 human CTNND1 1500 O60716 CTNND1 human T906 469141 sLDNNystPNERGDH X X -MAPK3 ERK1 P27361 human GATA1 14460 P17679 Gata1 mouse S178 451236 PFFSPTGsPLSSAAY X -MAPK3 ERK1 P27361 human CBP 1387 Q92793 CREBBP human S93 20615901 IGNVSASsPVQQGLG X -MAPK3 ERK1 P27361 human ARRB2 409 P32121 ARRB2 human S14 23083983 TRVFKKssPNCKLtV X -MAPK3 ERK1 P27361 human AML1 iso8 861 Q01196-8 RUNX1 human S276 454399 DTRQIQPsPPWSYDQ X -MAPK3 ERK1 P27361 human CACNB1 50688 P54283 Cacnb1 rat S348 459046 IVYIKITsPKVLQRL Guanylate_kin X -MAPK3 ERK1 P27361 human MFN1 192647 Q8R4Z9 Mfn1 rat T562 40416800 VPRSLAStPTAPSNP X X -MAPK3 ERK1 P27361 human SMURF1 57154 Q9HCE7 SMURF1 human T223 1877492900 DVRGSLQtPQNRPHG X X -MAPK3 ERK1 P27361 human NG2 81651 Q00657 Cspg4 rat T2314 483998 ELLQFCRtPNPALRN X -MAPK3 ERK1 P27361 human FRA2 14284 P47930 Fosl2 mouse T322 14573760 SDSLNsPtLLAL___ X -MAPK3 ERK1 P27361 human Fos 2353 P01100 FOS human S374 448482 PSSDSLSsPtLLAL_ X -MAPK3 ERK1 P27361 human JAK2 16452 Q62120 Jak2 mouse S523 465671 GISDVQIsPtLQRHN X -MAPK3 ERK1 P27361 human MCR 4306 P08235 NR3C2 human S196 25692901 EKSPSVCsPLNMTSS X X -MAPK3 ERK1 P27361 human Abi-1 10006 Q8IZP0 ABI1 human S410 12626407 DIPMFDDsPPPPPPP X -MAPK3 ERK1 P27361 human NUP214 8021 P35658 NUP214 human S1809 10296401 NAPAFGQsPGFGQGG X -MAPK3 ERK1 P27361 human MZF-1 109889 O70162 Mzf1 mouse S336 448731 EEVGGIFsPGFTLQM X -MAPK3 ERK1 P27361 human SMAD2 4087 Q15796 SMAD2 human S255 448796 ELsPTTLsPVNHsLD X X 3104 -MAPK3 ERK1 P27361 human DLC1 50768 Q9R0Z9 Dlc1 mouse S129 20651248 KQDPIPGsPDNSRLQ X X -MAPK3 ERK1 P27361 human TOP2A 7153 P11388 TOP2A human S1247 452238 kNENtEGsPQEDGVE X -MAPK3 ERK1 P27361 human Fos 2353 P01100 FOS human T232 448491 GGLPEVAtPESEEAF X -MAPK3 ERK1 P27361 human ITGB4 3691 P16144 ITGB4 human S1356 451653 ysDDVLRsPSGsQRP X -MAPK3 ERK1 P27361 human DAT 24898 P23977 Slc6a3 rat T53 6843600 TLINPPQtPVEAQER X -MAPK3 ERK1 P27361 human TTK 398219 Q98T92 ttk frog S844 467281 GQLIGLNsPNSISRA X -MAPK3 ERK1 P27361 human CAPN2 12334 O08529 Capn2 mouse S50 451162 GALFQDPsFPALPSS Peptidase_C2 X -MAPK3 ERK1 P27361 human PML iso4 5371 P29590-4 PML human T28 451468 PTMPPPEtPSEGRQP X -MAPK3 ERK1 P27361 human CREM 1390 Q03060 CREM human S277 450066 AsPGsLHsPQQLAEE X -MAPK3 ERK1 P27361 human GLE1 2733 Q53GS7 GLE1 human S99 18010022 ssAFsPAsPAtPNGT X -MAPK3 ERK1 P27361 human DUSP4 319520 Q8BFV3 Dusp4 mouse T363 15412237 ERGKAtPtPTSQFVF X X -MAPK3 ERK1 P27361 human ARHGEF2 iso2 9181 Q92974-2 ARHGEF2 human T678 449343 PGVELLLtPREPALP X -MAPK3 ERK1 P27361 human WSTF 9031 Q9UIG0 BAZ1B human S158 3215310 ksDGACDsPssDKEN X -MAPK3 ERK1 P27361 human GAB2 14389 Q9Z1S8 Gab2 mouse S591 62877800 PVPSGTNsPAPKKST X X -MAPK3 ERK1 P27361 human FHOD1 29109 Q9Y613 FHOD1 human S498 1984218 PAARtPQsPAPCVLL X -MAPK3 ERK1 P27361 human AML1 iso8 861 Q01196-8 RUNX1 human T300 454403 sPSVHPAtPIsPGRA X -MAPK3 ERK1 P27361 human Raptor 57521 Q8N122 RPTOR human S696 11315003 EKNyALPsPAttEGG X X -MAPK3 ERK1 P27361 human Tau iso8 4137 P10636-8 MAPT human S396 449081 GAEIVyKsPVVsGDt X X 9632 -MAPK3 ERK1 P27361 human ARRB1 408 P49407 ARRB1 human S412 447493 EEEDGtGsPQLNNR_ X 2416 -MAPK3 ERK1 P27361 human ERK1 5595 P27361 MAPK3 human T207 3949243 FLtEyVAtRWyrAPE Pkinase X -MAPK3 ERK1 P27361 human DUSP6 1848 Q16828 DUSP6 human S197 455266 SATDSDGsPLSNSQP X -MAPK3 ERK1 P27361 human SERT 6532 P31645 SLC6A4 human T616 7576402 IKsItPEtPTEIPCG X -MAPK3 ERK1 P27361 human CIITA 4261 P33076 CIITA human S280 471421 TVHGLPTsPDRPGsT X X -MAPK3 ERK1 P27361 human Tau iso8 4137 P10636-8 MAPT human S404 449082 PVVsGDtsPRHLsNV X 35834; 20194; 98523; 91600; 49562 -MAPK3 ERK1 P27361 human SRC-1 8648 Q15788 NCOA1 human S1185 449064 GtPPASTsPFSQLAA DUF1518 X -MAPK3 ERK1 P27361 human dystrophin 13405 P11531 Dmd mouse S3059 35542205 GPWERAIsPNkVPYY WW X -MAPK3 ERK1 P27361 human TPD52 7163 P55327 TPD52 human S40 17555377 GNssPPGsPTLQKFG X X -MAPK3 ERK1 P27361 human OLA1 67059 Q9CZ30 Ola1 mouse S232 1880539202 MVYLVNLsEkDyIRK X X -MAPK3 ERK1 P27361 human SULT4A1 25830 Q9BR01 SULT4A1 human T11 2048305 SEAEtPStPGEFESK X -MAPK3 ERK1 P27361 human BIM 10018 O43521 BCL2L11 human S69 449330 GPLAPPAsPGPFATR X X 4581; 4585 -MAPK3 ERK1 P27361 human DEPTOR 64798 Q8TB45 DEPTOR human S235 4723788 MELLNEksPsSQEtH X X -MAPK3 ERK1 P27361 human MCTS1 28985 Q9ULC4 MCTS1 human T81 26348501 REGPFYPtLRLLHkY Pre-PUA X -MAPK3 ERK1 P27361 human hnRNP E2 5094 Q15366 PCBP2 human S272 482918 FsGIEsssPEVkGyW X X -MAPK3 ERK1 P27361 human BANP 54971 Q8N9N5 BANP human T337 41301700 VkSFSRRtPNSSSYC X -MAPK3 ERK1 P27361 human SYN1 24949 P09951 Syn1 rat S62 451572 stAAPVAsPAAPsPG X X -MAPK3 ERK1 P27361 human CdGAP 12549 A6X8Z5 Arhgap31 mouse T776 456517 tPAPPPPtPLEEEPE X X -MAPK3 ERK1 P27361 human STAR 20845 P51557 Star mouse S232 2089100 VLHPLAGsPSKTKLT START X -MAPK3 ERK1 P27361 human HNF4 alpha 3172 P41235 HNF4A human S147 20510202 RRssyEDssLPsINA X -MAPK3 ERK1 P27361 human Tau iso8 4137 P10636-8 MAPT human S262 447930 NVKskIGstENLkHQ Tubulin-binding X -MAPK3 ERK1 P27361 human TAL2 6887 Q16559 TAL2 human S100 10425400 LENYQVPsPGPSHHI X -MAPK3 ERK1 P27361 human SMAD4 4089 Q13485 SMAD4 human T277 449628 GSRtAPYtPNLPHHQ X -MAPK3 ERK1 P27361 human HNF4 alpha 3172 P41235 HNF4A human S313 449926 GkIkRLRsQVQVsLE Hormone_recep X -MAPK3 ERK1 P27361 human DUSP4 319520 Q8BFV3 Dusp4 mouse S395 15412246 LHsPITTsPSC____ X X -MAPK3 ERK1 P27361 human BTG2 12227 Q04211 Btg2 mouse S147 455911 QMMLGRSsPsKNYVM X -MAPK3 ERK1 P27361 human MLK3 4296 Q16584 MAP3K11 human S758 448611 GtPGtPRsPPLGLIS X -MAPK3 ERK1 P27361 human Trap170 9282 O60244 MED14 human S986 452549 NEDDNPPsPIGGDMM X -MAPK3 ERK1 P27361 human hnRNP K 3190 P61978 HNRNPK human S284 448185 rrDyDDMsPrrGPPP X X -MAPK3 ERK1 P27361 human FOXO3A 2309 O43524 FOXO3 human S294 472326 QLskWPGsPtsRsSD X 5538 -MAPK3 ERK1 P27361 human SHARPIN 81858 Q9H0F6 SHARPIN human T309 1879811806 APREAPAtGPsPQHP X -MAPK3 ERK1 P27361 human palladin 23022 Q8WX93 PALLD human S808 22826102 PPPPPVFsPTAAFPV X X -MAPK3 ERK1 P27361 human Fos 14281 P01101 Fos mouse S32 470080 DSLSYYHsPADSFSS X 5348; 8709; 8677; 99325 -MAPK3 ERK1 P27361 human MEK1 5604 Q02750 MAP2K1 human T292 448287 EtPPRPRtPGRPLss Pkinase X X 26975 -MAPK3 ERK1 P27361 human Kv4.2 Q63881 Kcnd2 rat S616 457613 EGDDRPEsPEYSGGN X -MAPK3 ERK1 P27361 human TH 7054 P07101 TH human S62 448544 SYTPTPRsPRFIGRR TOH_N X -MAPK3 ERK1 P27361 human ASB2 51676 Q96Q27 ASB2 human S371 29618900 RIRRSGVsPLHLAAE Ank_2 X -MAPK3 ERK1 P27361 human p90RSK 6195 Q15418 RPS6KA1 human S380 447990 HQLFRGFsFVAtGLM Pkinase_C X 9341; 9335; 13575; 11989; 12032; 75266; 93317; 13397; 13588 -MAPK3 ERK1 P27361 human FRA2 2355 P15408 FOSL2 human T322 14573760 SDsLNsPtLLAL___ X -MAPK3 ERK1 P27361 human CAD 101843763 P08955 Cad hamster T456 451248 KVYFLPItPHYVTQV X -MAPK3 ERK1 P27361 human STMN1 3925 P16949 STMN1 human S25 448555 QAFELILsPrskEsV Stathmin X -MAPK3 ERK1 P27361 human NUP50 10762 Q9UKX7 NUP50 human S315 4957816 TQSkPVSsPFPTkPL X X -MAPK3 ERK1 P27361 human BRAF 673 P15056 BRAF human T753 460657 yACAsPKtPIQAGGy X -MAPK3 ERK1 P27361 human PML iso4 5371 P29590-4 PML human S527 451472 PHLDGPPsPRsPVIG DUF3583 X -MAPK3 ERK1 P27361 human smMLCK 4638 Q15746 MYLK human S1779 468782 sstGsPtsPLNAEKL X -MAPK3 ERK1 P27361 human LRP6 4040 O75581 LRP6 human S1490 456289 AILNPPPsPAtERsH X X 2568 -MAPK3 ERK1 P27361 human capicua 23152 Q96RK0 CIC human S1389 4952030 sPRAILGsYRKKRKN X -MAPK3 ERK1 P27361 human SP3 6670 Q02447 SP3 human S73 1199100 CsKIGPPsPGDDEEE X -MAPK3 ERK1 P27361 human KIBRA 23286 Q8IX03 WWC1 human S548 30312500 SsPSPPCsPLMADPL X X -MAPK3 ERK1 P27361 human FGFR1 2260 P11362 FGFR1 human S777 2721300 SMPLDQysPsFPDTR X X -MAPK3 ERK1 P27361 human SYN1 24949 P09951 Syn1 rat S549 451574 PAARPPAsPsPQRQA X -MAPK3 ERK1 P27361 human GSK3B 2932 P49841 GSK3B human T43 456221 kVTTVVAtPGQGPDR X -MAPK3 ERK1 P27361 human Lck 3932 P06239 LCK human S59 447820 EGSNPPAsPLQDNLV X -MAPK3 ERK1 P27361 human LIFR 3977 P42702 LIFR human S1044 450385 WNLVsPDsPRsIDSN X X -MAPK3 ERK1 P27361 human BAG3 9531 O95817 BAG3 human S377 452222 PVPCPPPsPGPsAVP X -MAPK3 ERK1 P27361 human Cortactin 2017 Q14247 CTTN human S405 447700 KtQtPPVsPAPQPtE X X -MAPK3 ERK1 P27361 human RRas2 22800 P62070 RRAS2 human S186 484150 QEQECPPsPEPtRkE X X -MAPK3 ERK1 P27361 human PDE4D iso2 5144 Q08499-2 PDE4D human S579 451090 YQSTIPQsPSPAPDD X X -MAPK3 ERK1 P27361 human MARS 4141 P56192 MARS1 human S209 27452641 LQkQPQPsPAEGRAV X X -MAPK3 ERK1 P27361 human SHARPIN 81858 Q9H0F6 SHARPIN human S165 3245774 PEADLPRsPGNLtER X X -MAPK3 ERK1 P27361 human Caldesmon iso4 800 Q05682-4 CALD1 human S534 448466 QSVDKVTsPTKV___ X -MAPK3 ERK1 P27361 human TCF8 25705 Q62947 Zeb1 rat T867 469215 DQNDSDCtPPKKKTR X -MAPK3 ERK1 P27361 human Fos 2353 P01100 FOS human T331 448484 CtPVVTCtPSCTAYT X -MAPK3 ERK1 P27361 human MCR 4306 P08235 NR3C2 human S263 18503884 NVGsPLssPLSSMKS X X -MAPK3 ERK1 P27361 human smMLCK 4638 Q15746 MYLK human S947 4739853 EEERKVHsPQQVDFR X -MAPK3 ERK1 P27361 human HNF4 alpha 3172 P41235 HNF4A human S262 63076100 CPELAEMsRVsIRIL Hormone_recep X -MAPK3 ERK1 P27361 human MCR 4306 P08235 NR3C2 human S227 25692900 FGSFPVHsPITQGTP X X -MAPK3 ERK1 P27361 human SMAD2 4087 Q15796 SMAD2 human S250 448795 TGsPAELsPTTLsPV X X 3104 -MAPK3 ERK1 P27361 human FAM195B 348262 C9JLW8 MCRIP1 human T30 9322247 PsSsEIFtPAHEENV FAM195 X -MAPK3 ERK1 P27361 human p90RSK 81771 Q63531 Rps6ka1 rat S363 447989 TSRtPRDsPGIPPsA Pkinase_C X 9344 -MAPK3 ERK1 P27361 human AML3 860 Q13950 RUNX2 human S43 10892805 PGKMSDVsPVVAAQQ X -MAPK3 ERK1 P27361 human GTF2I iso2 2969 P78347-2 GTF2I human S633 452350 QsPKRPRsPGSNSKV X X -MAPK3 ERK1 P27361 human PPAR-gamma 19016 P37238 Pparg mouse S112 448062 AIkVEPAsPPYYSEK X -MAPK3 ERK1 P27361 human DHPS 1725 P49366 DHPS human S233 1870426002 KNHIPVFsPALTDGS DS X X -MAPK3 ERK1 P27361 human GAB2 14389 Q9Z1S8 Gab2 mouse S614 12097630 DFQPGsPsPHRKPst X X -MAPK3 ERK1 P27361 human SPHK2 56848 Q9NRA0 SPHK2 human T614 477182 AFRLEPLtPRGVLTV YegS_C X X -MAPK3 ERK1 P27361 human STIM1 20866 P70302 Stim1 mouse S608 3195758 PSVPPGGsPLLDSSH X X -MAPK3 ERK1 P27361 human p53 7157 P04637 TP53 human S392 447535 FktEGPDsD______ X 9281 -MAPK3 ERK1 P27361 human Tau iso8 4137 P10636-8 MAPT human T153 449076 DGKtKIAtPRGAAPP X -MAPK3 ERK1 P27361 human DUSP1 1843 P28562 DUSP1 human S359 448660 SALSYLQsPITTsPS X X 2857 -MAPK3 ERK1 P27361 human MZF-1 109889 O70162 Mzf1 mouse S374 448856 SLSGQIQsPTTEGGF X -MAPK3 ERK1 P27361 human PTP-SL iso2 19279 Q62132-2 Ptprr mouse T253 450119 EPFVAVStPREKVAM X -MAPK3 ERK1 P27361 human AR 367 P10275 AR human S651 448414 GEASSTTsPTEETTQ X -MAPK3 ERK1 P27361 human CIITA 4261 P33076 CIITA human S288 2286408 PDRPGsTsPFAPsAT X -MAPK3 ERK1 P27361 human OLA1 67059 Q9CZ30 Ola1 mouse Y236 1880539204 VNLsEkDyIRKKNKW X -MAPK3 ERK1 P27361 human STMN1 3925 P16949 STMN1 human S38 448556 sVPEFPLsPPkKkDL Stathmin X 3426; 4191 -MAPK3 ERK1 P27361 human TTK 7272 P33981 TTK human S821 467281 GQLVGLNsPNsILkA X -MAPK3 ERK1 P27361 human NUP50 10762 Q9UKX7 NUP50 human S221 476622 kVAAEtQsPsLFGst X X -MAPK3 ERK1 P27361 human STAT3 6774 P40763 STAT3 human S727 448191 NtIDLPMsPrTLDSL X 9134; 9136; 34911; 94994; 49081; 58978; 87544; 71958; 50804 -MAPK3 ERK1 P27361 human eplin 65970 Q9ERG0 Lima1 mouse S692 460654 NHVHAQQsPLEPEAP X X -MAPK3 ERK1 P27361 human Fos 314322 P12841 Fos rat S374 448482 PSSDSLSsPTLLAL_ X -MAPK3 ERK1 P27361 human FOXO3A 2309 O43524 FOXO3 human S425 2058400 TKGsGLGsPtSSFNS X 64616 -MAPK3 ERK1 P27361 human PIP5K1C 23396 O60331 PIP5K1C human S650 457599 DERSWVysPLHYSAQ X -MAPK3 ERK1 P27361 human HSP75 10131 Q12931 TRAP1 human S511 55374803 NrHLAEHsPyyEAMk HSP90 X -MAPK3 ERK1 P27361 human myocardin 214384 Q8VIM5 Myocd mouse S812 10791200 EVLLNSHsPIGKVSD X X -MAPK3 ERK1 P27361 human RAB3IP 29885 Q62739 Rab3ip rat S250 482771 VLSSsPTsPTQEPLA Sec2p X -MAPK3 ERK1 P27361 human PR 18667 Q00175 Pgr mouse S294 447987 SPIAPGRsPLATTVV Prog_receptor X 13736 -MAPK3 ERK1 P27361 human CACNA1B 100008979 Q05152 CACNA1B rabbit S411 459047 DRNAEEKsPLDAVLK X -MAPK3 ERK1 P27361 human NPAS4 225872 Q8BGD7 Npas4 mouse T423 1871095704 LSKDLVCtPPYtPHQ X -MAPK3 ERK1 P27361 human LIN28A 83557 Q8K3Y3 Lin28a mouse S200 7231811 EEEEEIHsPALLPEA X X -MAPK3 ERK1 P27361 human SP1 6667 P08047 SP1 human T739 448227 sEGSGtAtPSALITT X X -MAPK3 ERK1 P27361 human hnRNP E2 5094 Q15366 PCBP2 human T213 482919 SASFPHTtPSMCLNP X X -MAPK3 ERK1 P27361 human hnRNP K 3190 P61978 HNRNPK human S353 450147 DSAIDTWsPSEWQMA X -MAPK3 ERK1 P27361 human HNF4 alpha 3172 P41235 HNF4A human S138 20510206 QNERDRIstRRssyE X -MAPK3 ERK1 P27361 human TR-beta1 7068 P10828 THRB human S142 449635 IQKNLHPsYSCkYEG zf-C4 X X -MAPK3 ERK1 P27361 human STIM1 20866 P70302 Stim1 mouse S621 3635048 SHSLSPSsPDPDTPs X X -MAPK3 ERK1 P27361 human AML3 860 Q13950 RUNX2 human S24 10892806 FFWDPSTsRRFsPPS X -MAPK3 ERK1 P27361 human OSBP2 23762 Q969R2 OSBP2 human S762 11171320 ECSKVMHssPssPsS Oxysterol_BP X -MAPK3 ERK1 P27361 human CACNB1 50688 P54283 Cacnb1 rat S161 459045 CEVGFIPsPVKLDSL X -MAPK3 ERK1 P27361 human Symplekin 8189 Q92797 SYMPK human T1257 3208452 VGEDAMKtPsPAAED X -MAPK3 ERK1 P27361 human PAP-alpha 18789 Q61183 Papola mouse S537 1737605 DNSMSVPsPTSAMKT X X -MAPK3 ERK1 P27361 human TH iso3 7054 P07101-3 TH human S31 448544 KQAEAIMsPRFIGRR TOH_N X -MAPK3 ERK1 P27361 human NPAS4 225872 Q8BGD7 Npas4 mouse S615 1871095701 GLLtPEAsPVKQSFF X -MAPK3 ERK1 P27361 human GRHL1 29841 Q9NZI5 GRHL1 human S76 3252757 KVPRERRssTAKPEV X -MAPK3 ERK1 P27361 human SMAD2 4087 Q15796 SMAD2 human S245 448794 NQsMDTGsPAELsPT X X 3104 -MAPK3 ERK1 P27361 human E2F4 1874 Q16254 E2F4 human S384 4763386 FAPLLRLsPPPGDHD X X -MAPK3 ERK1 P27361 human TRPV3 162514 Q8NET8 TRPV3 human T264 334535805 EGFYFGEtPLALAAC Ank X -MAPK3 ERK1 P27361 human NUP153 9972 P49790 NUP153 human T369 3191104 PPVQRLMtPKPVsIA Nup153 X -MAPK3 ERK1 P27361 human Bcl-6 604 P41182 BCL6 human S333 447600 KGLVsPQsPQKsDCQ X -MAPK3 ERK1 P27361 human HNF4 alpha 3172 P41235 HNF4A human T469 458373 AIPQPtItKQEVI__ X -MAPK3 ERK1 P27361 human Abi-1 10006 Q8IZP0 ABI1 human S183 486178 PPtQKPPsPPMsGRG X -MAPK3 ERK1 P27361 human SYN1 24949 P09951 Syn1 rat S67 451573 VAsPAAPsPGSSGGG X X -MAPK3 ERK1 P27361 human p21Cip1 1026 P38936 CDKN1A human S98 478193 GGRRPGTsPALLQGT X -MAPK3 ERK1 P27361 human STMN1 396057 P31395 STMN1 chicken S38 448556 AAPEFPLsPPKKKDL Stathmin X -MAPK3 ERK1 P27361 human CdGAP 12549 A6X8Z5 Arhgap31 mouse T769 1791606 RNLsPPLtPAPPPPt X -MAPK3 ERK1 P27361 human CTNND1 1500 O60716 CTNND1 human T310 450457 GtARRtGtPsDPRRR X -MAPK3 ERK1 P27361 human ERK5 5598 Q13164 MAPK7 human T733 455520 LPPVFsGtPKGSGAG X -MAPK3 ERK1 P27361 human Abi-1 10006 Q8IZP0 ABI1 human S225 1983922 ARLGsQHsPGRtAsL X -MAPK3 ERK1 P27361 human BRAF 673 P15056 BRAF human S151 478631 VARsNPKsPQKPIVR X -MAPK3 ERK1 P27361 human DUSP5 1847 Q16690 DUSP5 human T321 10206802 ESEILPStPNPQPPS X -MAPK3 ERK1 P27361 human HSPB8 26353 Q9UJY1 HSPB8 human T87 467970 GVPAEGRtPPPFPGE X -MAPK3 ERK1 P27361 human YTHDF2 51441 Q9Y5A9 YTHDF2 human S39 483929 DDFEPyLsPQARPNN X X -MAPK3 ERK1 P27361 human CRYAB 12955 P23927 Cryab mouse S45 448748 FSTATSLsPFYLRPP Crystallin X -MAPK3 ERK1 P27361 human OSBP2 23762 Q969R2 OSBP2 human S766 15721694 VMHssPssPsSDGKQ Oxysterol_BP X -MAPK3 ERK1 P27361 human PML iso4 5371 P29590-4 PML human S530 451473 DGPPsPRsPVIGsEV DUF3583 X -MAPK3 ERK1 P27361 human STAT3 20848 P42227 Stat3 mouse S727 448191 NtIDLPMsPRTLDSL X 9134; 9136; 34911; 94994; 49081; 58978; 87544; 71958; 50804 -MAPK3 ERK1 P27361 human SREBP-2 6721 Q12772 SREBF2 human S432 451007 NQNVLLMsPPASDSG X X -MAPK3 ERK1 P27361 human AML3 860 Q13950 RUNX2 human S314 10892801 LSQMTsPsIHSTTPL X -MAPK3 ERK1 P27361 human GLE1 2733 Q53GS7 GLE1 human T102 472369 FsPAsPAtPNGTKGk X -MAPK3 ERK1 P27361 human SRC-2 10499 Q15596 NCOA2 human S736 465446 tIkQEPVsPkkKENA DUF4927 X -MAPK3 ERK1 P27361 human SREBP-1 6720 P36956 SREBF1 human S117 469986 YPSMPAFsPGPGIkE X X -MAPK3 ERK1 P27361 human FOXO3A 2309 O43524 FOXO3 human S12 9318037 PAsPAPLsPLEVELD X -MAPK3 ERK1 P27361 human DUSP4 1846 Q13115 DUSP4 human S386 15412243 SSLPYLHsPITTsPS X -MAPK3 ERK1 P27361 human GLRA1 14654 Q64018 Glra1 mouse S408 1869137000 PPPAPSKsPEEMRkL X -MAPK3 ERK1 P27361 human GR 2908 P04150 NR3C1 human S226 451796 IDENCLLsPLAGEDD GCR X 97285 -MAPK3 ERK1 P27361 human TMEM55B 219024 Q3TWL2 Pip4p1 mouse S76 4717517 GEDPPPYsPLTsPDs Tmemb_55A X -MAPK3 ERK1 P27361 human E2F4 1874 Q16254 E2F4 human S244 28843800 QEASRPNsPQLTPTA X X -MAPK3 ERK1 P27361 human AML3 860 Q13950 RUNX2 human S503 3053613 ADGsHSSsPTVLNSS RunxI X -MAPK3 ERK1 P27361 human eplin 51474 Q9UHB6 LIMA1 human S604 459750 FQstsVKsPKtVsPP X -MAPK3 ERK1 P27361 human Abi-1 10006 Q8IZP0 ABI1 human S267 18715503 PIAVPtPsPPTIGPE X -MAPK3 ERK1 P27361 human myocardin 214384 Q8VIM5 Myocd mouse S859 10791202 ELLPGPLsPMHAQLs X X -MAPK3 ERK1 P27361 human HNF4 alpha 3172 P41235 HNF4A human T166 15501727 EVLSRQItsPVsGIN X -MAPK3 ERK1 P27361 human KSR 16706 Q61097 Ksr1 mouse S443 449300 TTSSTPSsPAPFLTS X -MAPK3 ERK1 P27361 human N-Myc 4613 P04198 MYCN human S62 448222 LLPtPPLsPsrGFAE Myc_N X -MAPK3 ERK1 P27361 human AML1 iso8 861 Q01196-8 RUNX1 human S303 454401 VHPAtPIsPGRASGM X -MAPK3 ERK1 P27361 human Bcl-2 596 P10415 BCL2 human S87 448396 AAAGPALsPVPPVVH X -MAPK3 ERK1 P27361 human p27Kip1 1027 P46527 CDKN1B human T187 447875 NAGsVEQtPKKPGLR X -MAPK3 ERK1 P27361 human Tau iso8 4137 P10636-8 MAPT human S46 447926 tDAGLkEsPLQtPtE X 20296 -MAPK3 ERK1 P27361 human NFAT3 4776 Q14934 NFATC4 human S676 455348 SNGRRKRsPTQSFRF RHD_dimer X X -MAPK3 ERK1 P27361 human MCR 4306 P08235 NR3C2 human S361 25692903 TLRDVVPsPDTQEKG X X -MAPK3 ERK1 P27361 human MBP 4155 P02686 MBP human T232 450929 KNIVTPRtPPPSQGK Myelin_MBP X -MAPK3 ERK1 P27361 human WAVE2 10163 Q9Y6W5 WASF2 human S351 18715500 PGtPPPPsPPSFPPH X -MAPK3 ERK1 P27361 human TOP2A 7153 P11388 TOP2A human S1361 455094 sPPKTKtsPKLsNkE X -MAPK3 ERK1 P27361 human MCL1 4170 Q07820 MCL1 human T92 4825134 EVPDVTAtPARLLFF X -MAPK3 ERK1 P27361 human HER2 2064 P04626 ERBB2 human T701 472481 TELVEPLtPsGAMPN X -MAPK3 ERK1 P27361 human 4E-BP1 1978 Q13541 EIF4EBP1 human S65 447527 FLMECrNsPVtktPP eIF_4EBP X 9451; 9456; 13443 -MAPK3 ERK1 P27361 human SMAD2 Q1W668 SMAD2 cow S255 448796 ELsPTTLsPVNHSLD X -MAPK3 ERK1 P27361 human C/EBP-alpha 1050 P49715 CEBPA human S21 448308 PMsSHLQsPPHAPSS X X 2841 -MAPK3 ERK1 P27361 human Caldesmon 281660 NP_776683 CALD1 cow S531 448466 QSVDKVTsPTKV___ X -MAPK3 ERK1 P27361 human HER4 2066 Q15303 ERBB4 human S1051 1869951802 NRSEIGHsPPPAyTP X -MAPK3 ERK1 P27361 human DUSP6 67603 Q9DBB1 Dusp6 mouse S159 455265 DGSCSSSsPPLPVLG X -MAPK3 ERK1 P27361 human NUP153 9972 P49790 NUP153 human S516 3191083 TNKVQMtsPsstGsP Nup153 X -MAPK3 ERK1 P27361 human RAB3IP 29885 Q62739 Rab3ip rat S247 2023489 KTLVLSSsPTsPTQE Sec2p X -MAPK3 ERK1 P27361 human Tau iso8 4137 P10636-8 MAPT human S202 447928 sGyssPGsPGtPGsR X 39357; 30505 -MAPK3 ERK1 P27361 human RAF1 5894 P04049 RAF1 human S289 455311 RsHsEsAsPsALsss X X 9431 -MAPK3 ERK1 P27361 human DUSP5 1847 Q16690 DUSP5 human S376 10206801 TVSELSRsPVATATS X -MAPK3 ERK1 P27361 human NUP153 9972 P49790 NUP153 human S257 3191077 ktsQLGDsPFyPGkT Nup153 X -MAPK3 ERK1 P27361 human HNF4 alpha 3172 P41235 HNF4A human S95 63076102 VRKNHMYsCRFsRQC zf-C4 X -MAPK3 ERK1 P27361 human PKM 5315 P14618 PKM human S37 476070 MCRLDIDsPPItARN X -MAPK3 ERK1 P27361 human METTL3 56339 Q86U44 METTL3 human S43 483736 rNPEAALsPTFRsDs X -MAPK3 ERK1 P27361 human PXN iso2 5829 P49023-2 PXN human S130 450228 KQKsAEPsPtVMSts Paxillin X -MAPK3 ERK1 P27361 human MAZ 4150 P56270 MAZ human T72 451250 AAPAPPPtPQAPAAE X X -MAPK3 ERK1 P27361 human Caldesmon 800 Q05682 CALD1 human S759 448465 ktPDGNksPAPKPsD Caldesmon X -MAPK3 ERK1 P27361 human HIF2A 2034 Q99814 EPAS1 human S672 56668652 APLGPPVsPPHVSTF X X -MAPK3 ERK1 P27361 human STIM1 20866 P70302 Stim1 mouse S575 468876 LVEKLPDsPALAKKT X X -MAPK3 ERK1 P27361 human p21Cip1 1026 P38936 CDKN1A human S130 455618 sGEQAEGsPGGPGDs X -MAPK3 ERK1 P27361 human FRA2 2355 P15408 FOSL2 human S320 4707550 QSSDsLNsPtLLAL_ X -MAPK3 ERK1 P27361 human BAD 572 Q92934 BAD human S75 447860 EIRsRHssyPAGtED Bcl-2_BAD X 9291; 5284; 9296; 5193; 11865; 94223 -MAPK3 ERK1 P27361 human RXRA 6256 P19793 RXRA human S260 450891 NMGLNPssPNDPVtN Hormone_recep X X -MAPK3 ERK1 P27361 human NUP153 9972 P49790 NUP153 human S338 468337 IVssPLNsPLDrsGI Nup153 X -MAPK3 ERK1 P27361 human palladin 23022 Q8WX93 PALLD human S688 18013438 APRsAPPsPPFPPPP X X -MAPK3 ERK1 P27361 human BIK 12124 O70337 Bik mouse T116 25171001 IWSWRVLtPGAWVSP bcl-2I13 X -MAPK3 ERK1 P27361 human SRm300 75956 Q8BTI8 Srrm2 mouse S1068 453278 GsLsRsssPVtELtA X -MAPK3 ERK1 P27361 human HDAC6 10013 Q9UBN7 HDAC6 human S1035 29604201 DHQtPPtsPVQGttP X -MAPK3 ERK1 P27361 human eIF4G iso8 1981 Q04637-8 EIF4G1 human S1232 449798 EAALPPVsPLKAALs X -MAPK3 ERK1 P27361 human RAB3IP 29885 Q62739 Rab3ip rat S19 37039803 VNLAsPTsPDLLGVC X -MAPK3 ERK1 P27361 human KLF4 16600 Q60793 Klf4 mouse S132 24976100 ASASSSSsPASSGPA X -MAPK3 ERK1 P27361 human PLCB1 23236 Q9NQ66 PLCB1 human S982 4787475 KkKsEPssPDHGssT X X -MAPK3 ERK1 P27361 human CAPN2 824 P17655 CAPN2 human S50 451162 GTLFQDPsFPAIPSA Peptidase_C2 X X -MAPK3 ERK1 P27361 human ER-alpha 2099 P03372 ESR1 human S118 448101 LHPPPQLsPFLQPHG Oest_recep X X 2511 -MAPK3 ERK1 P27361 human MKL1 57591 Q969V6 MRTFA human S454 467355 tGstPPVsPtPsERS X -MAPK3 ERK1 P27361 human GRK2 282682 P21146 GRK2 cow S670 447725 KMKNKPRsPVVELSK X -MAPK3 ERK1 P27361 human supervillin Q6U1J6 SVIL ferret S132 7721700 DSEADSEsPSRYTKS X X -MAPK3 ERK1 P27361 human NIPA 232679 Q80YV2 Zc3hc1 mouse S358 483339 tRsWEsssPVDRPEL X -MAPK3 ERK1 P27361 human METTL3 56339 Q86U44 METTL3 human S525 1871246003 YGMIERLsPGTRKIE MT-A70 X -MAPK3 ERK1 P27361 human GAB1 14388 Q9QYY0 Gab1 mouse S552 454074 ELQAPVRsPITRSFA X -MAPK3 ERK1 P27361 human DUSP4 319520 Q8BFV3 Dusp4 mouse T361 25123903 LRERGKAtPtPTSQF X X -MAPK3 ERK1 P27361 human GABRA1 29705 P62813 Gabra1 rat T375 471418 APTATSytPNLARGD X -MAPK3 ERK1 P27361 human PDE4D iso6 24627 P14270-6 Pde4d rat S585 451090 YQSTIPQsPSPAPDD X -MAPK3 ERK1 P27361 human NUP153 9972 P49790 NUP153 human S320 4747698 QsLEkMssPLADAkR Nup153 X -MAPK3 ERK1 P27361 human ER-alpha 2099 P03372 ESR1 human S106 448100 PLNsVsPsPLMLLHP Oest_recep X -MAPK3 ERK1 P27361 human 5-LO 240 P09917 ALOX5 human S664 461913 QLPYYYLsPDRIPNs X 3749 -MAPK3 ERK1 P27361 human DUSP4 319520 Q8BFV3 Dusp4 mouse S390 15412243 SNLPYLHsPITTsPS X X -MAPK3 ERK1 P27361 human capicua 23152 Q96RK0 CIC human S1409 453485 sAPEDPtsPKRKMRR X -MAPK3 ERK1 P27361 human p47phox 653361 P14598 NCF1 human S345 451727 QARPGPQsPGsPLEE X X -MAPK3 ERK1 P27361 human mGluR5 108071 Q3UVX5 Grm5 mouse S1158 25581600 LVALtPPsPFRDSVD GluR_Homer-bdg X -MAPK3 ERK1 P27361 human WTAP 9589 Q15007 WTAP human T148 36131377 ELSAWkFtPDSQTGK Wtap X -MAPK3 ERK1 P27361 human Oct4 5460 Q01860 POU5F1 human S111 25236703 EsNsDGAsPEPCtVt X -MAPK3 ERK1 P27361 human Cofilin-1 12631 P18760 Cfl1 mouse T25 7990494 MkVRKSstPEEVKkR Cofilin_ADF X -MAPK3 ERK1 P27361 human MLK3 4296 Q16584 MAP3K11 human S705 448610 FSLKtPDsPPtPAPL X -MAPK3 ERK1 P27361 human DUSP6 67603 Q9DBB1 Dusp6 mouse S197 455266 SATDSDGsPLSNSQP X -MAPK3 ERK1 P27361 human TOB1 10140 P50616 TOB1 human S152 455535 PASSVSSsPsPPFGH X X -MAPK3 ERK1 P27361 human Tau iso8 4137 P10636-8 MAPT human T217 449078 sRtPsLPtPPtREPK X 33134; 51625 -MAPK3 ERK1 P27361 human HNF4 alpha 3172 P41235 HNF4A human T467 63076104 LsAIPQPtItKQEVI X -MAPK3 ERK1 P27361 human CDCA5 113130 Q96FF9 CDCA5 human S209 3208965 DMtLPGIsPPPEKQK Sororin X -MAPK3 ERK1 P27361 human RPS3 6188 P23396 RPS3 human T42 455909 sGVEVRVtPTRtEII KH_2 X X -MAPK3 ERK1 P27361 human BIM 64547 O88498 Bcl2l11 rat S65 449330 GPLAPPAsPGPFATR X X 4581; 4585 -MAPK3 ERK1 P27361 human PXN 360820 Q66H76 Pxn rat S130 450228 KQKsAEPsPtVMSss Paxillin X X -MAPK3 ERK1 P27361 human XBP1 7494 P17861 XBP1 human S68 21688102 RQRLTHLsPEEkALR bZIP_2 X -MAPK3 ERK1 P27361 human eplin 65970 Q9ERG0 Lima1 mouse S360 455424 PMHPKPLsPDARTSs X X -MAPK3 ERK1 P27361 human TWIST1 7291 Q15672 TWIST1 human S68 18905000 GGGDEPGsPAQGkRG X X -MAPK3 ERK1 P27361 human CTNND1 1500 O60716 CTNND1 human T308 3651652 DyGtARRtGtPsDPR X -MAPK3 ERK1 P27361 human DUSP1 1843 P28562 DUSP1 human S364 448661 LQsPITTsPSC____ X X -MAPK3 ERK1 P27361 human ARHGEF2 iso2 9181 Q92974-2 ARHGEF2 human S959 467500 SRLSPPHsPRDFTRM X X -MAPK3 ERK1 P27361 human BAG3 9531 O95817 BAG3 human T285 467534 GsPARsstPLHsPsP X -MAPK3 ERK1 P27361 human Tau iso8 4137 P10636-8 MAPT human T50 447931 LkEsPLQtPtEDGsE X -MAPK3 ERK1 P27361 human Tel 2120 P41212 ETV6 human S213 451376 DNMIRRLsPAERAQG X X -MAPK3 ERK1 P27361 human RAB5A 5868 P20339 RAB5A human S123 457391 kELQRQAsPNIVIAL Ras X -MAPK3 ERK1 P27361 human AML1 iso8 861 Q01196-8 RUNX1 human S462 454402 AEGSHSNsPTNMAPS RunxI X -MAPK3 ERK1 P27361 human MED1 5469 Q15648 MED1 human T1457 449866 HsKsPAytPQNLDsE X -MAPK3 ERK1 P27361 human ARHGEF2 9181 Q92974 ARHGEF2 human T679 449343 PGVELLLtPREPALP X -MAPK3 ERK1 P27361 human MSK1 9252 O75582 RPS6KA5 human S360 448215 TEMDPTYsPAALPQS Pkinase_C X 9594 -MAPK3 ERK1 P27361 human NPAS4 225872 Q8BGD7 Npas4 mouse T611 1871095703 LVPEGLLtPEAsPVK X -MAPK3 ERK1 P27361 human SMAD2 4087 Q15796 SMAD2 human T8 448792 MsSILPFtPPVVkRL X X -MAPK3 ERK1 P27361 human SEC16A 9919 O15027 SEC16A human T593 455894 GsVsQPstPsPPKPt X X -MAPK3 ERK1 P27361 human CBX7 52609 Q8VDS3 Cbx7 mouse T119 29669800 TNGPPPWtPTLPSSE CBX7_C X -MAPK3 ERK1 P27361 human SPHK2 56848 Q9NRA0 SPHK2 human S387 477181 PATVEPAsPTPAHSL X X -MAPK3 ERK1 P27361 human Jun 3725 P05412 JUN human S73 447943 VGLLkLAsPELERLI Jun X X 9164; 3270; 8752; 12714; 77955 -MAPK3 ERK1 P27361 human MEK1 5604 Q02750 MAP2K1 human T286 448286 VEGdAAEtPPRPRtP Pkinase X X 9127 -MAPK3 ERK1 P27361 human HSF1 3297 Q00613 HSF1 human S307 449046 EPPsPPQsPRVEEAs Vert_HS_TF X -MAPK3 ERK1 P27361 human FBXW7 55294 Q969H0 FBXW7 human S176 25126709 KRKLDHGsEVRSFSL X X -MAPK3 ERK1 P27361 human HSF4 3299 Q9ULV5 HSF4 human S298 4037600 LLkEEPAsPGGDGEA X X -MAPK3 ERK1 P27361 human eplin 65970 Q9ERG0 Lima1 mouse S602 459750 FRTSsIKsPKAssPS X X -MAPK3 ERK1 P27361 human FRA2 14284 P47930 Fosl2 mouse S320 4707550 QSSDSLNsPtLLAL_ X -MAPK3 ERK1 P27361 human METTL3 56339 Q86U44 METTL3 human S50 3204585 sPTFRsDsPVPtAPt X -MAPK3 ERK1 P27361 human USP11 8237 P51784 USP11 human S948 466974 GssGAPAsPACssPP X -MAPK3 ERK1 P27361 human EPS8 13860 Q08509 Eps8 mouse S624 7101206 ADtPsAPsPPPtPAP X -MAPK3 ERK1 P27361 human Abi-1 10006 Q8IZP0 ABI1 human T394 12626406 ENIADsPtPPPPPPP X -MAPK3 ERK1 P27361 human FAM195B 348262 C9JLW8 MCRIP1 human S21 486127 kRtssPRsPPsSsEI FAM195 X -MAPK3 ERK1 P27361 human TACE 11491 Q9Z0F8 Adam17 mouse T735 449804 kPFPAPQtPGRLQAL X -MAPK3 ERK1 P27361 human NUP153 9972 P49790 NUP153 human S529 452707 sPMFKFSsPIVKsTE Nup153 X X -MAPK3 ERK1 P27361 human GTF2I iso2 2969 P78347-2 GTF2I human S627 452349 INTKALQsPKRPRsP X X -MAPK3 ERK1 P27361 human HSPB8 26353 Q9UJY1 HSPB8 human S27 7994902 PFRDsPLsSRLLDDG X -MAPK3 ERK1 P27361 human CASP8 841 Q14790 CASP8 human S387 16855100 yLEMDLSsPQTRYIP Peptidase_C14 X -MAPK3 ERK1 P27361 human Bcl-2 12043 P10417 Bcl2 mouse S70 448395 RDMAARtsPLRPLVA X X -MAPK3 ERK1 P27361 human PTPRCAP 5790 Q14761 PTPRCAP human S163 4733815 EGDLVLGsPGPASAG PTPRCAP X X -MAPK3 ERK1 P27361 human NCKIPSD 51517 Q9NZQ3 NCKIPSD human T242 1868827200 PGSSCSPtPPPVPRr X X -MAPK3 ERK1 P27361 human Raptor 57521 Q8N122 RPTOR human S863 453732 LtQsAPAsPtNkGVH X X -MAPK3 ERK1 P27361 human STAT5A 6776 P42229 STAT5A human S780 448750 DsLDsRLsPPAGLFT X X -MAPK3 ERK1 P27361 human MCL1 17210 P97287 Mcl1 mouse T144 455375 ADGsLPStPPPPEEE X 4579 -MAPK3 ERK1 P27361 human Tau iso8 4137 P10636-8 MAPT human T181 447932 ktPPAPktPPssGEP X X 12885; 66224; 62672 -MAPK3 ERK1 P27361 human JunD 24518 P52909 Jund rat S100 456168 LGLLKLAsPELERLI Jun X 9164 -MAPK3 ERK1 P27361 human MCR 4306 P08235 NR3C2 human S287 4767239 SVKsPVSsPNNVTLR X X -MAPK3 ERK1 P27361 human STF-1 26423 P33242 Nr5a1 mouse S203 447603 EYPEPYAsPPQQPGP X -MAPK3 ERK1 P27361 human DRP1 10059 O00429 DNM1L human S616 454690 PIPIMPAsPQKGHAV X X 3455; 4494; 63940 -MAPK3 ERK1 P27361 human TAL1 6886 P17542 TAL1 human S122 450663 DGRMVQLsPPALAAP X -MAPK3 ERK1 P27361 human DNMT3A Q4W5Z4 DNMT3A chicken S220 4700048 QQPTDPAsPNVATTP X -MAPK3 ERK1 P27361 human REST 5978 Q13127 REST human S864 453739 TEDLsPPsPPLPKEN X -MAPK3 ERK1 P27361 human gephyrin 64845 Q03555 Gphn rat S281 483463 AsLSttPsEsPRAQA X -MAPK3 ERK1 P27361 human EGFR 1956 P00533 EGFR human T693 448054 RELVEPLtPsGEAPN X X 3056; 8808 -MAPK3 ERK1 P27361 human HNF4 alpha 3172 P41235 HNF4A human S142 458368 DRIstRRssyEDssL X -MAPK3 ERK1 P27361 human RAC1 5879 P63000 RAC1 human T108 27458396 VrHHCPNtPIILVGT Ras X X -MAPK3 ERK1 P27361 human NHE1 24782 P26431 Slc9a1 rat S775 475073 MIRsKEPssPGTDDV X -MAPK3 ERK1 P27361 human KARS 3735 Q15046 KARS1 human S207 9392600 PYEITLLsPCLHMLP X -MAPK3 ERK1 P27361 human MARCKS 4082 P29966 MARCKS human S46 454165 VKVNGDAsPAAAEsG MARCKS X -MAPK3 ERK1 P27361 human BAG3 9531 O95817 BAG3 human S289 469169 RsstPLHsPsPIRVH X -MAPK3 ERK1 P27361 human ATF-2 11909 P16951 Atf2 mouse T53 448225 IVADQtPtPtRFLKN X 9225; 9221; 5112; 94125; 13850; 40749; 15411; 24329; 61584; 27934; 92109; 20534; 35858 -MAPK3 ERK1 P27361 human Jun 3725 P05412 JUN human S63 447686 kNsDLLtsPDVGLLk Jun X X 5464; 9261; 2361; 97721; 91952 -MAPK3 ERK1 P27361 human NHE1 24782 P26431 Slc9a1 rat S776 475074 IRsKEPssPGTDDVF X -MAPK3 ERK1 P27361 human PML iso4 5371 P29590-4 PML human S38 451470 EGRQPsPsPsPTERA X -MAPK3 ERK1 P27361 human DUSP4 1846 Q13115 DUSP4 human S391 15412246 LHsPITTsPSC____ X -MAPK3 ERK1 P27361 human eplin 51474 Q9UHB6 LIMA1 human S374 452503 AssLsEssPPKAMKK X -MAPK3 ERK1 P27361 human CDK2 1017 P24941 CDK2 human T160 447739 GVPVRtytHEVVtLW Pkinase X 2561 -MAPK3 ERK1 P27361 human FOXO3A 2309 O43524 FOXO3 human S344 2058401 QDDDAPLsPMLYSSS X -MAPK3 ERK1 P27361 human ELK4 2005 P28324 ELK4 human S381 4317600 IHFWSTLsPVAPLsP X X -MAPK3 ERK1 P27361 human MZF-1 109889 O70162 Mzf1 mouse S354 448855 TAEPDMMsPHLHVPW X -MAPK3 ERK1 P27361 human PTP-PEST 5782 Q05209 PTPN12 human S571 1983755 KtVsLtPsPtTQVEt X X -MAPK3 ERK1 P27361 human SHOC2 8036 Q9UQ13 SHOC2 human T507 1867945200 GLGENLLtHLPEEIG LRR_8 X -MAPK3 ERK1 P27361 human Abi-1 10006 Q8IZP0 ABI1 human S392 12626405 VQENIADsPtPPPPP X -MAPK3 ERK1 P27361 human AML3 12393 Q08775 Runx2 mouse S380 10892804 DPRQAQSsPPWSYDQ X -MAPK3 ERK1 P27361 human GLRA1 2741 P23415 GLRA1 human S408 1869137000 PPPAPSKsPEEMRKL X -MAPK3 ERK1 P27361 human MCL1 4170 Q07820 MCL1 human T163 455375 tDGsLPstPPPAEEE X X 4579; 14765 -MAPK3 ERK1 P27361 human smMLCK 396445 P11799 MYLK chicken S1768 468782 AsGssPTsPINADKV X -MAPK3 ERK1 P27361 human myocardin 214384 Q8VIM5 Myocd mouse T893 10791203 TMEWLDLtPPSSTPG X X -MAPK3 ERK1 P27361 human Tau iso8 4137 P10636-8 MAPT human T175 449077 AtRIPAktPPAPktP X -MAPK3 ERK1 P27361 human Abi-1 10006 Q8IZP0 ABI1 human S216 3205884 VPNDyMtsPARLGsQ X -MAPK3 ERK1 P27361 human Abi-1 10006 Q8IZP0 ABI1 human T265 18715504 GIPIAVPtPsPPTIG X -MAPK3 ERK1 P27361 human SHC1 20416 P98083 Shc1 mouse S36 448508 TPPEELPsPSASSLG X -MAPK3 ERK1 P27361 human CACNA1B 100008979 Q05152 CACNA1B rabbit S447 459048 TGLCAPGsPFARASL X -MAPK3 ERK1 P27361 human MCR 4306 P08235 NR3C2 human S238 25692902 QGTPLTCsPNVENRG X X -MAPK3 ERK1 P27361 human HNF4 alpha 3172 P41235 HNF4A human T139 8081928 NERDRIstRRssyED X -MAPK3 ERK1 P27361 human OSBP2 23762 Q969R2 OSBP2 human S768 15721697 HssPssPsSDGKQKT Oxysterol_BP X -MAPK3 ERK1 P27361 human Ets-1 23871 P27577 Ets1 mouse T38 447950 CADVPLLtPSsKEMM X X -MAPK3 ERK1 P27361 human TOP2A 7153 P11388 TOP2A human S1354 452240 DFVPsDAsPPKTKts X -MAPK3 ERK1 P27361 human GATA4 14463 Q08369 Gata4 mouse S261 450013 IKPQRRLsASRRVGL X -MAPK3 ERK1 P27361 human HNF4 alpha 3172 P41235 HNF4A human S143 458369 RIstRRssyEDssLP X -MAPK3 ERK1 P27361 human HNF4 alpha 3172 P41235 HNF4A human S167 458371 VLSRQItsPVsGING X -MAPK3 ERK1 P27361 human Myc 4609 P01106 MYC human S77 448586 LLPtPPLsPsRRsGL Myc_N X 13748 -MAPK3 ERK1 P27361 human MAFG 4097 O15525 MAFG human S124 18011934 FARTVARsPVAPARG X X -MAPK3 ERK1 P27361 human IL2RB 3560 P14784 IL2RB human T476 41591300 PQPLGPPtPGVPDLV X -MAPK3 ERK1 P27361 human p90RSK 81771 Q63531 Rps6ka1 rat T573 447993 AENGLLMtPCYTANF Pkinase X 9346 -MAPK3 ERK1 P27361 human hnRNP E2 5094 Q15366 PCBP2 human S173 482916 MLETLSQsPPKGVtI X X -MAPK3 ERK1 P27361 human STMN1 16765 P54227 Stmn1 mouse S25 448555 QAFELILsPRskEsV Stathmin X -MAPK3 ERK1 P27361 human C/EBP-beta 12608 P28033 Cebpb mouse T188 447878 sSssPPGtPSPADAK X X 3084 -MAPK3 ERK1 P27361 human GRASP55 26003 Q9H8Y8 GORASP2 human T225 470123 QMAGtPItPLKDGFT X -MAPK3 ERK1 P27361 human MED1 5469 Q15648 MED1 human T1032 458308 SSSNRPFtPPTsTGG X -MAPK3 ERK1 P27361 human AML3 860 Q13950 RUNX2 human S340 4169883 TDVPRRIsDDDTATs X -MAPK3 ERK1 P27361 human ARRB2 409 P32121 ARRB2 human T276 50247604 FCKVYTItPLLSDNR Arrestin_C X -MAPK3 ERK1 P27361 human Securin 30939 Q9CQJ7 Pttg1 mouse S162 452603 LLHLGPPsPLKTPFL Securin X X -MAPK3 ERK1 P27361 human NFAT2 4772 O95644 NFATC1 human S172 465577 YRDPsCLsPASSLSS X -MAPK3 ERK1 P27361 human ARHGAP26 396113 Q5ZMW5 ARHGAP26 chicken S686 452134 PMFSAPSsPMPTSST X -MAPK3 ERK1 P27361 human GATA4 54254 P46152 Gata4 rat S105 449604 AYTPPPVsPRFSFPG GATA-N X -MAPK3 ERK1 P27361 human Tau iso8 4137 P10636-8 MAPT human T212 447934 tPGsRsRtPsLPtPP X -MAPK3 ERK1 P27361 human PDE4D iso6 5144 Q08499-6 PDE4D human S651 451090 YQSTIPQsPSPAPDD X -MAPK3 ERK1 P27361 human PML iso4 5371 P29590-4 PML human S36 451469 PSEGRQPsPsPsPTE X -MAPK3 ERK1 P27361 human eplin 51474 Q9UHB6 LIMA1 human S362 455424 PVHPkPLsPDsRAss X -MAPK3 ERK1 P27361 human LRP6 4040 O75581 LRP6 human T1572 3802448 EPVPPPPtPRsQyLs X -MAPK3 ERK1 P27361 human RHOA 387 P61586 RHOA human T100 53332704 ENIPEKWtPEVkHFC Ras X X -MAPK3 ERK1 P27361 human EEF2K 25435 P70531 Eef2k rat S358 447826 GTEEKCGsPRIRTLs X -MAPK3 ERK1 P27361 human Raptor 57521 Q8N122 RPTOR human S8 17538200 MESEMLQsPLLGLGE X X -MAPK3 ERK1 P27361 human CAD 790 P27708 CAD human T456 451248 KVYFLPItPHYVTQV X -MAPK3 ERK1 P27361 human SP1 6667 P08047 SP1 human T453 448226 SGPIIIRtPTVGPNG X -MAPK3 ERK1 P27361 human OSBP2 23762 Q969R2 OSBP2 human S763 31727226 CSKVMHssPssPsSD Oxysterol_BP X -MAPK3 ERK1 P27361 human HSF1 3297 Q00613 HSF1 human S326 455484 ssVDtLLsPTALIDs Vert_HS_TF X -MAPK3 ERK1 P27361 human FBXW7 55294 Q969H0 FBXW7 human T205 25585000 GLVPCSAtPTTFGDL X X -MAPK3 ERK1 P27361 human TAB1 10454 Q15750 TAB1 human S438 456224 tPTLTNQsPTLtLQS X -MAPK3 ERK1 P27361 human iNOS 4843 P35228 NOS2 human S745 763800 KSRQNLQsPTSSRAT FAD_binding_1 X X -MAPK3 ERK1 P27361 human NUP153 9972 P49790 NUP153 human S334 468336 RIPsIVssPLNsPLD Nup153 X -MAPK3 ERK1 P27361 human HDAC6 10013 Q9UBN7 HDAC6 human T1031 29604202 ASStDHQtPPtsPVQ X X -MAPK3 ERK1 P27361 human RARG 5916 P13631 RARG human S79 455544 EMVPSsPsPPPPPRV X -MAPK3 ERK1 P27361 human NUP214 8021 P35658 NUP214 human S1710 10296402 VSSSGFSsPAFGTTA X -MAPK3 ERK1 P27361 human Cortactin 2017 Q14247 CTTN human S418 447701 tEErLPssPVyEDAA X X -MAPK3 ERK1 P27361 human MSK1 9252 O75582 RPS6KA5 human T581 448217 PDNQPLKtPCFTLHY Pkinase X 9595 -MAPK3 ERK1 P27361 human DUSP6 1848 Q16828 DUSP6 human S300 5938000 CLAGISRsVTVTVAY DSPc X -MAPK3 ERK1 P27361 human NOXA1 10811 Q86UR1 NOXA1 human S282 12570900 VGKQAPLsPGLPAMG X -MAPK3 ERK1 P27361 human BANP 54971 Q8N9N5 BANP human T352 41301701 PSEPMMStPPPASEL X -MAPK3 ERK1 P27361 human Bcl-2 596 P10415 BCL2 human T56 448655 FSSQPGHtPHPAASR X 2875 -MAPK3 ERK1 P27361 human NUP153 9972 P49790 NUP153 human T413 10296400 TGYEkNMtPGQNREQ Nup153 X -MAPK3 ERK1 P27361 human Calnexin 821 P27824 CANX human S583 449100 EDEILNRsPRNRKPR X -MAPK3 ERK1 P27361 human hnRNP E2 5094 Q15366 PCBP2 human S189 482917 yRPkPsssPVIFAGG X X -MAPK3 ERK1 P27361 human GAB2 14389 Q9Z1S8 Gab2 mouse Y441 448384 SASSDDNyVPMNPGS X 3881; 3882 -MAPK3 ERK1 P27361 human GAB2 14389 Q9Z1S8 Gab2 mouse S469 4825114 QSVYIPMsPGPHHFD X X -MAPK3 ERK1 P27361 human mGluR5 108071 Q3UVX5 Grm5 mouse T1155 1872043501 LEELVALtPPsPFRD GluR_Homer-bdg X -MAPK3 ERK1 P27361 human Kv4.2 Q63881 Kcnd2 rat T607 457612 IPtPPVTtPEGDDRP X -MAPK3 ERK1 P27361 human KIBRA 23286 Q8IX03 WWC1 human S542 25673102 sPRSsLSsPSPPCsP X -MAPK3 ERK1 P27361 human ELK1 2002 P19419 ELK1 human S383 447872 IHFWSTLsPIAPRsP X X 9181; 9186 -MAPK3 ERK1 P27361 human Fos 2353 P01100 FOS human T325 448483 TELEPLCtPVVTCtP X -MAPK3 ERK1 P27361 human RAB3IP 29885 Q62739 Rab3ip rat S16 37039802 FHEVNLAsPTsPDLL X -MAPK3 ERK1 P27361 human GATA6 2627 Q92908 GATA6 human S266 2833503 VSARFPYsPsPPMAN GATA-N X -MAPK3 ERK1 P27361 human CDK5 12568 P49615 Cdk5 mouse Y15 448022 EkIGEGtyGtVFKAK Pkinase X 94254; 19051 -MAPK3 ERK1 P27361 human p53 7157 P04637 TP53 human S15 447490 PsVEPPLsQEtFsDL P53_TAD X 4030; 9235; 9284; 9286; 8695; 8514; 82530; 56979 -MAPK3 ERK1 P27361 human KLC1 16593 O88447 Klc1 mouse S459 477826 YKACKVDsPtVtttL X X -MAPK3 ERK1 P27361 human GLE1 2733 Q53GS7 GLE1 human S93 31084897 PKsPDAssAFsPAsP X -MAPK3 ERK1 P27361 human TOB1 10140 P50616 TOB1 human S164 455537 FGHSAAVsPTFMPRS X X -MAPK3 ERK1 P27361 human AML3 860 Q13950 RUNX2 human S28 3053615 PSTsRRFsPPSssLQ X -MAPK3 ERK1 P27361 human MARS 4141 P56192 MARS1 human S825 3193240 GGGQAktsPKPAVVE X X -MAPK3 ERK1 P27361 human GATA4 14463 Q08369 Gata4 mouse S105 449604 AYTPPPVsPRFSFPG GATA-N X -MAPK3 ERK1 P27361 human PML iso4 5371 P29590-4 PML human S40 451471 RQPsPsPsPTERAPA X -MAPK3 ERK1 P27361 human RSHL2 83861 Q86UC2 RSPH3 human T286 15414618 AFLDRPPtPLFIPAK Radial_spoke_3 X X -MAPK3 ERK1 P27361 human RAF1 5894 P04049 RAF1 human S296 455218 sPsALsssPNNLsPt X X 9431; 9423 -MAPK3 ERK1 P27361 human GAB2 9846 Q9UQC2 GAB2 human S623 454021 ALDFQPssPsPHRKP X X -MAPK3 ERK1 P27361 human RRas 6237 P10301 RRAS human S201 18015221 QEQELPPsPPsAPRK X X -MAPK3 ERK1 P27361 human GRASP65 56082 O35254 Gorasp1 rat S277 455582 EQLPGPGsPGHGTAD X X -MAPK3 ERK1 P27361 human SH2-B-beta 25970 Q9NRF2 SH2B1 human S96 457414 PPILAPLsPGAEIsP X -MAPK3 ERK1 P27361 human ERK1 5595 P27361 MAPK3 human Y204 447543 HtGFLtEyVAtRWyr Pkinase X 9106; 4370; 4374; 9101; 4375; 4376; 4377; 3510; 5726; 88569; 13214; 13148; 70235; 9488; 89967; 8544; 14196; 14227; 14095; 14474; 75165; 98168; 33370; 54240; 15892; 45899; 55088; 9524; 69217; 48735 -MAPK3 ERK1 P27361 human myocardin 214384 Q8VIM5 Myocd mouse S866 10791201 sPMHAQLsPPSVDSS X X -MAPK3 ERK1 P27361 human SPHK1 20698 Q8CI15 Sphk1 mouse S225 460682 VASKRPAstLVQKGP X -MAPK3 ERK1 P27361 human DAPK1 1612 P53355 DAPK1 human S734 454887 NsSRFPPsPLASKPT X -MAPK3 ERK1 P27361 human AML1 iso8 861 Q01196-8 RUNX1 human S293 454400 QYLGSIAsPSVHPAt X -MAPK3 ERK1 P27361 human GLE1 2733 Q53GS7 GLE1 human S92 50831365 VPKsPDAssAFsPAs X -MAPK3 ERK1 P27361 human Tau iso8 4137 P10636-8 MAPT human T205 447933 ssPGsPGtPGsRsRt X 25377; 43964; 53001; 49561; 20060; 33032; 30505; 20739; 98160 -MAPK3 ERK1 P27361 human WAVE2 10163 Q9Y6W5 WASF2 human T346 18715502 VGFGsPGtPPPPsPP X -MAPK3 ERK1 P27361 human TOP2A 7153 P11388 TOP2A human S1393 452242 GsVPLsssPPAtHFP X -MAPK3 ERK1 P27361 human XBP1 7494 P17861 XBP1 human S181 27523600 QQVQAQLsPLQNISP X -MAPK3 ERK1 P27361 human EPS8 13860 Q08509 Eps8 mouse T628 9467900 sAPsPPPtPAPVPVP X -MAPK3 ERK1 P27361 human EWS 2130 Q01844 EWSR1 human T79 7359501 QPPTGYTtPTAPQAY X -MAPK3 ERK1 P27361 human LIN28A 79727 Q9H9Z2 LIN28A human S200 7231811 EEEEEIHsPtLLPEA X X 20607 -MAPK3 ERK1 P27361 human Tau iso8 4137 P10636-8 MAPT human S422 449083 GsIDMVDsPQLAtLA X -MAPK3 ERK1 P27361 human HNF4 alpha 3172 P41235 HNF4A human S461 63076103 AtIVkPLsAIPQPtI X -MAPK3 ERK1 P27361 human NUP153 9972 P49790 NUP153 human S522 3191092 tsPsstGsPMFKFSs Nup153 X -MAPK3 ERK1 P27361 human p300 2033 Q09472 EP300 human S2039 31828207 GLGQVGIsPLKPGTV Creb_binding X -MAPK3 ERK1 P27361 human HNF4 alpha 3172 P41235 HNF4A human S151 20510207 yEDssLPsINALLQA X -MAPK3 ERK1 P27361 human Tau iso8 4137 P10636-8 MAPT human S235 449080 VVRtPPKsPssAKsR X 20473 -MAPK3 ERK1 P27361 human YTHDF2 51441 Q9Y5A9 YTHDF2 human T381 6223825 SQAGSGstPsEPHPV X X -MAPK3 ERK1 P27361 human GLE1 2733 Q53GS7 GLE1 human S88 12667856 QPSFVPKsPDAssAF X -MAPK3 ERK1 P27361 human SREBP-2 6721 Q12772 SREBF2 human S455 451008 SIDSEPGsPLLDDAK X X -MAPK3 ERK1 P27361 human NR0B2 23957 Q62227 Nr0b2 mouse S26 7596703 TILYALLsPSPRTRP X X -MAPK3 ERK1 P27361 human NPAS4 225872 Q8BGD7 Npas4 mouse S577 1871095700 LYEKLPPsPSsPGNG X -MAPK3 ERK1 P27361 human K8 3856 P05787 KRT8 human S432 448540 sAyGGLtsPGLsysL X X -MAPK3 ERK1 P27361 human PR 5241 P06401 PGR human S294 447987 APMAPGRsPLATTVM Prog_receptor X X 13736 -MAPK3 ERK1 P27361 human SMAD2 4087 Q15796 SMAD2 human T220 448793 QSNYIPEtPPPGYIS X X -MAPK3 ERK1 P27361 human p300 2033 Q09472 EP300 human S1038 10941006 STSATQssPAPGQsk X -MAPK3 ERK1 P27361 human TOP2A 7153 P11388 TOP2A human S1213 452237 QMAEVLPsPRGQRVI X -MAPK3 ERK1 P27361 human HNF4 alpha 3172 P41235 HNF4A human S265 63076101 LAEMsRVsIRILDEL Hormone_recep X -MAPK3 ERK1 P27361 human C/EBP-beta 1051 P17676 CEBPB human T235 447878 SsssPPGtPSPADAK X 3084 -MAPK3 ERK1 P27361 human Bcl-6 604 P41182 BCL6 human S343 471422 KsDCQPNsPTESCSS X -MAPK3 ERK1 P27361 human Kv4.2 Q63881 Kcnd2 rat T602 457611 TAIISIPtPPVTtPE X -MAPK3 ERK1 P27361 human vinexin iso2 10174 O60504-2 SORBS3 human S188 452554 DGPQLPTsPRLTAAA X -MAPK3 ERK1 P27361 human HER4 2066 Q15303 ERBB4 human T699 9430151 TELVEPLtPSGTAPN X -MAPK3 ERK1 P27361 human AML3 iso5 12393 Q08775-5 Runx2 mouse S319 10892802 SYLSQMTsPSIHSTt X -MAPK3 ERK1 P27361 human CDCA5 113130 Q96FF9 CDCA5 human S79 470691 AVQsPRRsPRIsFFL X -MAPK3 ERK1 P27361 human Caldesmon 800 Q05682 CALD1 human S789 448466 QsVDKVtsPtKV___ X -MAPK3 ERK1 P27361 human MAGE-A11 4110 P43364 MAGEA11 human S174 2028416 EsPsPPQsPQEESFs MAGE_N X X -MAPK3 ERK1 P27361 human IRX2 373975 Q9PU52 IRX2 chicken S326 452193 AALGGRAsPGPPTPA X -MAPK3 ERK1 P27361 human Myb 4602 P10242 MYB human S532 453087 KIkQEVEsPtDKSGN Cmyb_C X X -MAPK3 ERK1 P27361 human IRS1 3667 P35568 IRS1 human S616 447562 DDGyMPMsPGVAPVP X 3193; 2386; 3203 -MAPK3 ERK1 P27361 human STAT1 20846 P42225 Stat1 mouse S727 447753 tDNLLPMsPEEFDEM STAT1_TAZ2bind X X 9177; 8826; 62390 -MAPK3 ERK1 P27361 human ARRB2 25388 P29067 Arrb2 rat T178 36120700 KVQFAPEtPGPQPSA X -MAPK3 ERK1 P27361 human HIF2A 2034 Q99814 EPAS1 human S484 1876807202 SSCSTPNsPEDYYTS X -MAPK3 ERK1 P27361 human AR 367 P10275 AR human S516 452166 VSRVPYPsPTCVkSE X -MAPK3 ERK1 P27361 human AML3 860 Q13950 RUNX2 human S275 10892803 PsLNSAPsPFNPQGQ X -MAPK3 ERK1 P27361 human EXOC7 23265 Q9UPT5 EXOC7 human S250 483909 sSSGVPysPAIPNKR X -MAPK3 ERK1 P27361 human TH 21823 P24529 Th mouse S31 448544 KQAEAVtsPRFIGRR TOH_N X 3370; 13041 -Dapk3 DAPK3 O54784 mouse MRLC2V 17906 P51667 Myl2 mouse S15 2846506 kRIEGGssNVFsMFE X -Dapk3 DAPK3 O54784 mouse DAPK3 13144 O54784 Dapk3 mouse T265 454892 KDPKRRMtIAQSLEH Pkinase X -Dapk3 DAPK3 O54784 mouse MRLC2V 363925 P08733 Myl2 rat S15 2846506 KRLEGGssNVFSMFE X -RIPK3 RIPK3 Q9Y572 human MLKL 74568 Q9D2Y4 Mlkl mouse T349 8148779 TQNsIsRtAKSTKAE PK_Tyr_Ser-Thr X -RIPK3 RIPK3 Q9Y572 human DAXX 1616 Q9UER7 DAXX human S668 448623 KKICtLPsPPsPLAs X -RIPK3 RIPK3 Q9Y572 human AMPKA1 105787 Q5EG47 Prkaa1 mouse T183 448786 sDGEFLRtsCGsPNY Pkinase X 2535; 2531; 4188; 5256; 50081; 74281 -RIPK3 RIPK3 Q9Y572 human RIPK3 11035 Q9Y572 RIPK3 human S227 23003800 VELPtEPsLVYEAVC Pkinase X X 93654 -RIPK3 RIPK3 Q9Y572 human MLKL 197259 Q8NB16 MLKL human T357 5891858 FELRkTQtsMSLGTt PK_Tyr_Ser-Thr X X -RIPK3 RIPK3 Q9Y572 human DLD 1738 P09622 DLD human T135 18262251 STAVkALtGGIAHLF Pyr_redox_2 X -RIPK3 RIPK3 Q9Y572 human MLKL 197259 Q8NB16 MLKL human S358 22996309 ELRkTQtsMSLGTtR PK_Tyr_Ser-Thr X X 91689; 18640 -RIPK3 RIPK3 Q9Y572 human RIPK3 56532 Q9QZL0 Ripk3 mouse S232 23003800 AELVDKtsLIRETVC Pkinase X 57220; 91702 -RIPK3 RIPK3 Q9Y572 human AMPKA2 108079 Q8BRK8 Prkaa2 mouse T172 448026 sDGEFLRtsCGsPNY Pkinase X 2535; 2531; 5256; 50081; 74281 -RIPK3 RIPK3 Q9Y572 human MLKL 74568 Q9D2Y4 Mlkl mouse S345 22996309 ELSKTQNsIsRtAKS PK_Tyr_Ser-Thr X 37333; 17825 -RIPK3 RIPK3 Q9Y572 human RIPK3 56532 Q9QZL0 Ripk3 mouse T231 27928506 EAELVDKtsLIRETV Pkinase X 57220; 91702 -RIPK3 RIPK3 Q9Y572 human MLKL 74568 Q9D2Y4 Mlkl mouse S347 29611200 SKTQNsIsRtAKSTK PK_Tyr_Ser-Thr X -RIPK3 RIPK3 Q9Y572 human RIPK3 56532 Q9QZL0 Ripk3 mouse S165 27928503 KLADFGLsTFQGGSQ Pkinase X -RIPK3 RIPK3 Q9Y572 human RIPK3 11035 Q9Y572 RIPK3 human T182 1174709701 GSGEPGGtLGYLAPE Pkinase X -RIPK3 RIPK3 Q9Y572 human TIF1B 10155 Q13263 TRIM28 human S473 452391 sGVkRsRsGEGEVsG X -RIPK3 RIPK3 Q9Y572 human RIPK3 11035 Q9Y572 RIPK3 human T224 50788489 GREVELPtEPsLVYE Pkinase X -RIPK3 RIPK3 Q9Y572 human STAT1 20846 P42225 Stat1 mouse S727 447753 tDNLLPMsPEEFDEM STAT1_TAZ2bind X 9177; 8826; 62390 -MAP4K1 HPK1 Q92918 human BLNK 17060 Q9QUN3 Blnk mouse T152 23303201 AKARLAStLPAPNsL X 49183; 62144 -MAP4K1 HPK1 Q92918 human CARD11 84433 Q9BXL7 CARD11 human S558 4737145 MQPPRsRssIMsITA X -MAP4K1 HPK1 Q92918 human GADS 17444 O89100 Grap2 mouse T254 451895 TLMHRRHtDPVQLQA X -MAP4K1 HPK1 Q92918 human MLK3 4296 Q16584 MAP3K11 human S281 448262 WHKtTQMsAAGTYAW PK_Tyr_Ser-Thr X -MAP4K1 HPK1 Q92918 human CARD11 84433 Q9BXL7 CARD11 human S556 4737139 tKMQPPRsRssIMsI X -MAP4K1 HPK1 Q92918 human PSMD2 5708 Q13200 PSMD2 human S361 487471 ENNrFGGsGsQVDsA X -MAP4K1 HPK1 Q92918 human SLP76 16822 Q60787 Lcp2 mouse S376 476784 IGFQQSAsLPPYFSQ X 14745; 76384; 76143; 63654; 47876; 61762; 94697; 15642; 10190 -MAP4K1 HPK1 Q92918 human HPK1 11184 Q92918 MAP4K1 human T165 455473 ISAQIGAtLARRLsF Pkinase X -MAP4K1 HPK1 Q92918 human SLP76 3937 Q13094 LCP2 human S376 476784 SSFPQsAsLPPYFSQ X X 14745; 90247; 40887; 92711; 16318; 76384; 76143; 63654; 83768; 47876; 61762; 94697; 15642; 10190; 72511 -Aurkc AurC O88445 mouse H3 360198 P68433 H3c1 mouse S10 455676 tkQTARkstGGkAPr Histone X 9701; 9711; 9606; 3465; 3642; 3377; 3475; 3458; 5764; 47398; 8481; 8552; 53348; 29237; 66065; 43185; 64522; 52725 -Aurkc AurC O88445 mouse AurC 20871 O88445 Aurkc mouse T171 455456 TPSLRRKtMCGtLDY Pkinase X 2914; 13464; 8525 -EPHB2 EphB2 P29323 human TAGAP 117289 Q8N103 TAGAP human Y310 6154570 TLQNDSAyDSNDPDV X -EPHB2 EphB2 P29323 human NCAM-L1 3897 P32004 L1CAM human Y1229 10272401 DGSFIGQySGKKEkE Bravo_FIGEY X -EPHB2 EphB2 P29323 human syndecan-2 25615 P34900 Sdc2 rat Y191 448376 RKPssAAyQKAPTKE Syndecan X X -EPHB2 EphB2 P29323 human syndecan-2 25615 P34900 Sdc2 rat Y179 448375 RKKDEGSyDLGERKP Syndecan X X -EPHB2 EphB2 P29323 human RRas 6237 P10301 RRAS human Y66 448122 DPTIEDSyTKICSVD Ras X -EPHB2 EphB2 P29323 human NCAM-L1 16728 P11627 L1cam mouse Y1232 10272401 DGsFIGQySGKKEKE Bravo_FIGEY X -EPHB2 EphB2 P29323 human Src 6714 P12931 SRC human Y419 448234 RLIEDNEytARQGAk PK_Tyr_Ser-Thr X 2101; 6943; 59548; 70926; 78740; 94361; 17320 -PAK2 PAK2 Q29502 rabbit PAK2 100009535 Q29502 PAK2 rabbit S192 448296 PRPDHTKsIYTRsVI X -PAK2 PAK2 Q29502 rabbit PAK2 100009535 Q29502 PAK2 rabbit S20 448298 APPVRMssTIFSTGG X -PAK2 PAK2 Q29502 rabbit PAK2 100009535 Q29502 PAK2 rabbit T402 448300 PEQSKRStMVGTPYW Pkinase X -PAK2 PAK2 Q29502 rabbit PAK2 100009535 Q29502 PAK2 rabbit S55 448299 KPRNKIIsIFSGTEK X -PAK2 PAK2 Q29502 rabbit PAK2 100009535 Q29502 PAK2 rabbit S19 449843 PAPPVRMssTIFSTG X -PAK2 PAK2 Q29502 rabbit PAK2 100009535 Q29502 PAK2 rabbit S141 448295 TVKQKYLsFTPPEKD X -PAK2 PAK2 Q29502 rabbit PAK2 100009535 Q29502 PAK2 rabbit S165 449844 NTKVSETsAVVTEED X -PAK2 PAK2 Q29502 rabbit PAK2 100009535 Q29502 PAK2 rabbit S197 448297 TKsIYTRsVIDPIPA X -Stk38l NDR2 Q7TSE6 mouse YAP1 22601 P46938 Yap1 mouse S382 3190672 TyHSRDEstDsGLSM X 13619 -Stk38l NDR2 Q7TSE6 mouse YAP1 22601 P46938 Yap1 mouse S112 448847 PQHVRAHssPAsLQL X 4911; 13008; 92367; 57706 -CAMKK1 CAMKK1 Q8N5S9 human AMPKA1 5562 Q13131 PRKAA1 human T183 448786 sDGEFLRtsCGsPNy Pkinase X 2535; 2531; 4188; 5256; 50081; 74281 -CAMKK1 CAMKK1 Q8N5S9 human CAMK1D 57118 Q8IU85 CAMK1D human T180 450469 GkGDVMstACGTPGY Pkinase X -CAMKK1 CAMKK1 Q8N5S9 human CAMK4 814 Q16566 CAMK4 human S12 2135600 TVPSCSAssCSSVTA X -CAMKK1 CAMKK1 Q8N5S9 human CAMK4 814 Q16566 CAMK4 human T200 448164 EHQVLMktVCGtPGY Pkinase X -CAMKK1 CAMKK1 Q8N5S9 human BRSK1 iso2 84446 Q8TDC3-2 BRSK1 human T205 456027 VGDSLLEtSCGsPHY Pkinase X -CAMKK1 CAMKK1 Q8N5S9 human PACSIN1 29704 Q9Z0W5 Pacsin1 rat T355 20503414 DRGQAYAtEWsDDEs X X -CAMKK1 CAMKK1 Q8N5S9 human CAMK4 814 Q16566 CAMK4 human S13 2135601 VPSCSAssCSSVTAS X -CAMKK1 CAMKK1 Q8N5S9 human CAMK1A 8536 Q14012 CAMK1 human T177 448527 DPGsVLstACGTPGY Pkinase X -Pim3 Pim3 P58750 mouse BAD 12015 Q61337 Bad mouse S170 447864 KGLPRPKsAGtATQM Bcl-2_BAD X -Pim3 Pim3 P58750 mouse BAD 12015 Q61337 Bad mouse S112 447860 ETRsRHssyPAGtEE Bcl-2_BAD X 9291; 5284; 9296; 5193; 11865; 94223 -Pim3 Pim3 P58750 mouse NOTCH3 18131 Q61982 Notch3 mouse S1673 11179168 ARRKREHsTLWFPEG X -Pim3 Pim3 P58750 mouse BAD 12015 Q61337 Bad mouse T173 1904506 PRPKsAGtATQMRQS Bcl-2_BAD X -Pim3 Pim3 P58750 mouse BAD 12015 Q61337 Bad mouse S96 1904505 QGRAAtNsHHGGAGA Bcl-2_BAD X -Pim3 Pim3 P58750 mouse BAD 12015 Q61337 Bad mouse T94 1904504 HQQGRAAtNsHHGGA Bcl-2_BAD X -Pim3 Pim3 P58750 mouse BAD 12015 Q61337 Bad mouse S155 447863 GRELRRMsDEFEGsF Bcl-2_BAD X 9297 -Pim3 Pim3 P58750 mouse BAD 12015 Q61337 Bad mouse S136 447862 PFRGRsRsAPPNLWA Bcl-2_BAD X 9295; 5286; 4366 -Map2k1 MEK1 Q01986 rat ERK1 50689 P21708 Mapk3 rat Y205 447543 HTGFLtEyVAtRWYR Pkinase X X 9106; 4370; 4374; 9101; 4375; 4376; 4377; 3510; 5726; 88569; 13214; 13148; 70235; 9488; 89967; 8544; 14196; 14227; 14095; 14474; 75165; 98168; 33370; 54240; 15892; 45899; 55088; 9524; 69217; 48735 -Map2k1 MEK1 Q01986 rat MEK1 170851 Q01986 Map2k1 rat S218 448514 VsGQLIDsMANsFVG Pkinase X X 9121; 3958; 9154; 86128 -Map2k1 MEK1 Q01986 rat ERK2 26413 P63085 Mapk1 mouse Y185 447594 HtGFLtEyVAtRWYR Pkinase X 9106; 4370; 4374; 9101; 4375; 4376; 4377; 3510; 5726; 88569; 13214; 13148; 70235; 9488; 89967; 8544; 14196; 14227; 14095; 14474; 75165; 98168; 33370; 54240; 15892; 45899; 55088; 9524; 69217; 48735 -Map2k1 MEK1 Q01986 rat ERK1 26417 Q63844 Mapk3 mouse T203 447542 HDHtGFLtEyVAtRW Pkinase X 9106; 4370; 4374; 9101; 4375; 4376; 4377; 3510; 5726; 88569; 13214; 13148; 70235; 9488; 89967; 8544; 14196; 14227; 14095; 14474; 75165; 98168; 33370; 54240; 15892; 45899; 55088; 9524; 69217; 48735 -Map2k1 MEK1 Q01986 rat ERK2 26413 P63085 Mapk1 mouse T183 447593 HDHtGFLtEyVAtRW Pkinase X 9106; 4370; 4374; 9101; 4375; 4376; 4377; 3510; 5726; 88569; 13214; 13148; 70235; 9488; 89967; 8544; 14196; 14227; 14095; 14474; 75165; 98168; 33370; 54240; 15892; 45899; 55088; 9524; 69217; 48735 -Map2k1 MEK1 Q01986 rat ERK2 116590 P63086 Mapk1 rat T183 447593 HDHtGFLtEyVAtRW Pkinase X X 9106; 4370; 4374; 9101; 4375; 4376; 4377; 3510; 5726; 88569; 13214; 13148; 70235; 9488; 89967; 8544; 14196; 14227; 14095; 14474; 75165; 98168; 33370; 54240; 15892; 45899; 55088; 9524; 69217; 48735 -Map2k1 MEK1 Q01986 rat ERK1 50689 P21708 Mapk3 rat T203 447542 HDHTGFLtEyVAtRW Pkinase X X 9106; 4370; 4374; 9101; 4375; 4376; 4377; 3510; 5726; 88569; 13214; 13148; 70235; 9488; 89967; 8544; 14196; 14227; 14095; 14474; 75165; 98168; 33370; 54240; 15892; 45899; 55088; 9524; 69217; 48735 -Map2k1 MEK1 Q01986 rat ERK1 26417 Q63844 Mapk3 mouse Y205 447543 HtGFLtEyVAtRWyR Pkinase X 9106; 4370; 4374; 9101; 4375; 4376; 4377; 3510; 5726; 88569; 13214; 13148; 70235; 9488; 89967; 8544; 14196; 14227; 14095; 14474; 75165; 98168; 33370; 54240; 15892; 45899; 55088; 9524; 69217; 48735 -Map2k1 MEK1 Q01986 rat Bcl-2 24224 P49950 Bcl2 rat S70 448395 RDTAARTsPLRPLVA X -Map2k1 MEK1 Q01986 rat MEK1 170851 Q01986 Map2k1 rat S222 448513 LIDsMANsFVGTRSY Pkinase X X 2338; 9121; 3958; 9154; 16211; 86128; 16780; 75262 -Map2k1 MEK1 Q01986 rat ERK2 116590 P63086 Mapk1 rat Y185 447594 HtGFLtEyVAtRWYR Pkinase X X 9106; 4370; 4374; 9101; 4375; 4376; 4377; 3510; 5726; 88569; 13214; 13148; 70235; 9488; 89967; 8544; 14196; 14227; 14095; 14474; 75165; 98168; 33370; 54240; 15892; 45899; 55088; 9524; 69217; 48735 -Map2k1 MEK1 Q01986 rat TH 25085 P04177 Th rat S31 448544 KQAEAVtsPRFIGRR TOH_N X 3370; 13041 -Jak2 JAK2 Q62120 mouse JAK2 16452 Q62120 Jak2 mouse Y972 470145 EyLGTKRyIHRDLAT PK_Tyr_Ser-Thr X X -Jak2 JAK2 Q62120 mouse JAK2 16452 Q62120 Jak2 mouse Y1008 448408 LPQDKEyyKVKEPGE PK_Tyr_Ser-Thr X 3771; 3776; 8082; 66245; 32901 -Jak2 JAK2 Q62120 mouse JAK2 16452 Q62120 Jak2 mouse Y570 451494 VRREVGDyGQLHKTE PK_Tyr_Ser-Thr X X -Jak2 JAK2 Q62120 mouse JAK3 16453 Q62137 Jak3 mouse Y820 1876350204 FEERHLKyISLLGKG PK_Tyr_Ser-Thr X -Jak2 JAK2 Q62120 mouse SH2-B-beta 89817 Q62985 Sh2b1 rat Y439 448753 DRLSQGAyGGLSDRP X X -Jak2 JAK2 Q62120 mouse ASS1 11898 P16460 Ass1 mouse Y87 4273690 SALYEDRyLLGTsLA Arginosuc_synth X X -Jak2 JAK2 Q62120 mouse JAK2 16452 Q62120 Jak2 mouse Y868 470141 GSVEMCRyDPLQDNT PK_Tyr_Ser-Thr X X -Jak2 JAK2 Q62120 mouse JAK2 16452 Q62120 Jak2 mouse Y206 470071 AVyNSVSyKTFLPKC FERM_F2 X -Jak2 JAK2 Q62120 mouse JAK2 16452 Q62120 Jak2 mouse Y119 470132 ILYRIRFyFPHWYCS FERM_F1 X -Jak2 JAK2 Q62120 mouse STAT3 20848 P42227 Stat3 mouse Y705 448192 DPGsAAPyLktkFIC X 4093; 9145; 4324; 9131; 9138; 4323; 4074; 4113; 48313; 20977; 25023; 8119; 52075; 52527; 73533; 61958; 73452; 16185; 74309 -Jak2 JAK2 Q62120 mouse JAK2 16452 Q62120 Jak2 mouse Y931 462253 NLRLIMEyLPyGSLR PK_Tyr_Ser-Thr X -Jak2 JAK2 Q62120 mouse JAK2 16452 Q62120 Jak2 mouse Y940 470144 PyGSLRDyLQKHKER PK_Tyr_Ser-Thr X -Jak2 JAK2 Q62120 mouse STAT5B 25126 P52632 Stat5b rat Y699 448198 TAKAADGyVKPQIKQ X 9365; 9356; 9359; 9351; 4322; 9314; 3939; 40284; 5387; 14603; 66740; 51879; 72712 -Jak2 JAK2 Q62120 mouse ATOH1 11921 P48985 Atoh1 mouse Y78 386186604 CTARAAQyLLHSPEL X -Jak2 JAK2 Q62120 mouse SHP-2 19247 P35235 Ptpn11 mouse Y327 451496 NSKPKKSyIATQGCL Y_phosphatase X -Jak2 JAK2 Q62120 mouse STAT5A 20850 P42230 Stat5a mouse Y694 447767 LAKAVDGyVkPQIKQ X 9365; 9356; 9359; 9351; 4322; 9314; 3939; 40284; 5387; 14603; 66740; 51879; 72712 -Jak2 JAK2 Q62120 mouse JAK2 16452 Q62120 Jak2 mouse Y637 470140 KFGsLDTyLKKNKNS PK_Tyr_Ser-Thr X X -Jak2 JAK2 Q62120 mouse JAK2 16452 Q62120 Jak2 mouse Y317 7603503 TEQDVQLyCDFPDII Jak1_Phl X -Jak2 JAK2 Q62120 mouse SH2-B-beta 89817 Q62985 Sh2b1 rat Y494 448754 VHPLSTPyPPLDTPE X X -Jak2 JAK2 Q62120 mouse JAK2 16452 Q62120 Jak2 mouse Y966 462255 QICKGMEyLGTKRyI PK_Tyr_Ser-Thr X X -Jak2 JAK2 Q62120 mouse p27Kip1 12576 P46414 Cdkn1b mouse Y88 456818 RGsLPEFyYRPPRPP X X -Jak2 JAK2 Q62120 mouse SHP-2 19247 P35235 Ptpn11 mouse Y304 451495 PNEPVSDyINANIIM Y_phosphatase X -Jak2 JAK2 Q62120 mouse JAK2 16452 Q62120 Jak2 mouse Y813 451492 NSLFTPDyELLTEND X -Jak2 JAK2 Q62120 mouse JAK2 16452 Q62120 Jak2 mouse Y1007 448407 VLPQDKEyyKVKEPG PK_Tyr_Ser-Thr X 3771; 3776; 4406; 66245; 32901 -Jak2 JAK2 Q62120 mouse GSK3B 56637 Q9WV60 Gsk3b mouse Y216 448569 RGEPNVsyICsRYYR Pkinase X X -Jak2 JAK2 Q62120 mouse JAK2 16452 Q62120 Jak2 mouse Y201 470070 DQTPLAVyNSVSyKT FERM_F2 X -Jak2 JAK2 Q62120 mouse JAK2 16452 Q62120 Jak2 mouse Y918 470142 VkyKGVCySAGRRNL PK_Tyr_Ser-Thr X -Jak2 JAK2 Q62120 mouse JAK2 16452 Q62120 Jak2 mouse Y934 470143 LIMEyLPyGSLRDyL PK_Tyr_Ser-Thr X -Jak2 JAK2 Q62120 mouse JAK3 16453 Q62137 Jak3 mouse Y976 447636 LLPLGKDyyVVREPG PK_Tyr_Ser-Thr X 5031; 32901 -Jak2 JAK2 Q62120 mouse JAK2 16452 Q62120 Jak2 mouse Y221 451493 VRAKIQDyHILTRKR FERM_F2 X X 3774 -Jak2 JAK2 Q62120 mouse JAK2 16452 Q62120 Jak2 mouse Y913 3345200 QHDNIVkyKGVCySA PK_Tyr_Ser-Thr X -BMP2K BIKE Q9NSY1 human AP2M1 1173 Q96CW1 AP2M1 human T156 448782 SQItsQVtGQIGWRR X 3843; 7399 -BMP2K BIKE Q9NSY1 human ENTH 9685 Q14677 CLINT1 human T294 3196412 LGAAAHytGDkAsPD X X -Camk4 CAMK4 P08414 mouse DRP1 74006 Q8K1M6 Dnm1l mouse S622 454690 PIPIMPAsPQKGHAV X X 3455; 4494; 63940 -Camk4 CAMK4 P08414 mouse CREB iso1 81646 P15337-1 Creb1 rat S133 448228 EILsRRPsYRkILND pKID X X 9187; 9196; 9198; 4095; 14228; 14001; 39561; 80120; 44864; 54960; 95995 -Camk4 CAMK4 P08414 mouse gp130 16195 Q00560 Il6st mouse S780 448180 QVFSRsEstQPLLDs X X -ALPK3 AlphaK1 Q96L96 human TIFA 92610 Q96CG3 TIFA human T177 4743087 SSQSSSPtEMDENES X -ALPK3 AlphaK1 Q96L96 human TIFA 92610 Q96CG3 TIFA human T9 50409900 tSFEDADtEEtVTCL X -ALPK3 AlphaK1 Q96L96 human TIFA 92610 Q96CG3 TIFA human T19 1881522404 tVTCLQMtVYHPGQL X -ALPK3 AlphaK1 Q96L96 human TIFA 92610 Q96CG3 TIFA human T2 1881522400 ______MtSFEDADt X -ALPK3 AlphaK1 Q96L96 human TIFA 92610 Q96CG3 TIFA human T12 1881522402 EDADtEEtVTCLQMt X -Fes Fes P16879 mouse HS1 15163 P49710 Hcls1 mouse Y405 451636 DEDAEGDyEDVLEPE X 8714; 13708; 11880 -Fes Fes P16879 mouse PECAM-1 18613 Q08481 Pecam1 mouse Y702 448760 TRATETVysEIRKVD X -Fes Fes P16879 mouse PECAM-1 18613 Q08481 Pecam1 mouse Y717 465455 PNLMENRysRTEGSL X -Fes Fes P16879 mouse HS1 15163 P49710 Hcls1 mouse Y388 451635 EPEtEPDyEDVGELD X -CDK11A CDK11A Q9UQ88 human SPDEF 25803 O95238 SPDEF human S238 54165904 SEESWTDsEVDssCS X X -CDK11A CDK11A Q9UQ88 human SPDEF 25803 O95238 SPDEF human S243 54165902 TDsEVDssCSGQPIH X X -CDK11A CDK11A Q9UQ88 human SPDEF 25803 O95238 SPDEF human S242 54165903 WTDsEVDssCSGQPI X X -Csnk2b CK2B P67874 rat CACNA1A 12286 P97445 Cacna1a mouse S2363 4713052 AHDAYsEsEDDWC__ X -Csnk2b CK2B P67874 rat CACNA1A 12286 P97445 Cacna1a mouse S2361 4713048 RGAHDAYsEsEDDWC X -CSNK1D CK1D P48730 human DVL2 13543 Q60838 Dvl2 mouse S594 22682201 EGSRssGstRsDGGA Dsh_C X -CSNK1D CK1D P48730 human HIF2A 2034 Q99814 EPAS1 human T528 59087902 FNELDLEtLAPYIPM HIF-1 X -CSNK1D CK1D P48730 human DVL2 13543 Q60838 Dvl2 mouse T595 27623903 GSRssGstRsDGGAG Dsh_C X -CSNK1D CK1D P48730 human TDP-43 23435 Q13148 TARDBP human S393 6855908 GsAsNAGsGsGFNGG X -CSNK1D CK1D P48730 human LZTS2 84445 Q9BRK4 LZTS2 human S224 1871717502 LSDsGRNsLSSLPTY X -CSNK1D CK1D P48730 human hnRNP P2 2521 P35637 FUS human S163 1878186700 GQQNQYNssSGGGGG X -CSNK1D CK1D P48730 human SNCA 6622 P37840 SNCA human T64 1876998407 EktkEQVtNVGGAVV Synuclein X -CSNK1D CK1D P48730 human YAP1 10413 P46937 YAP1 human S400 9764918 SRDEstDsGLsMsSy X X -CSNK1D CK1D P48730 human MDM2 4193 Q00987 MDM2 human T351 17342607 kAkLENstQAEEGFD X -CSNK1D CK1D P48730 human ATOH1 11921 P48985 Atoh1 mouse S347 57761905 PHSHYsDsDEAS___ X -CSNK1D CK1D P48730 human MDM2 4193 Q00987 MDM2 human S386 11956709 DDKITQAsQsQESED X -CSNK1D CK1D P48730 human BACE 23621 P56817 BACE1 human S498 450178 DDFADDIsLLk____ X -CSNK1D CK1D P48730 human ATOH1 11921 P48985 Atoh1 mouse S339 34425603 HRsDGEFsPHSHYsD X -CSNK1D CK1D P48730 human SMARCA4 6597 P51532 SMARCA4 human S35 1261736701 LGPsPGPsPGSAHSM X X -CSNK1D CK1D P48730 human APC 324 P25054 APC human S1507 452097 FsCsssLsALsLDEP APC_r X -CSNK1D CK1D P48730 human MDM2 4193 Q00987 MDM2 human S260 454923 sLDsEDYsLsEEGQE X -CSNK1D CK1D P48730 human MDM2 4193 Q00987 MDM2 human S350 17342609 EkAkLENstQAEEGF X -CSNK1D CK1D P48730 human p53 7157 P04637 TP53 human S9 447538 EEPQsDPsVEPPLsQ P53_TAD X 9288 -CSNK1D CK1D P48730 human SNCA 20617 O55042 Snca mouse T64 1876998407 EKtKEQVtNVGGAVV Synuclein X -CSNK1D CK1D P48730 human ATOH1 11921 P48985 Atoh1 mouse S311 57761906 AQKDLsPsLPGGILQ X -CSNK1D CK1D P48730 human LZTS2 84445 Q9BRK4 LZTS2 human S273 25299402 TGPsHsDsGRsssSK X -CSNK1D CK1D P48730 human p53 7157 P04637 TP53 human T18 447541 EPPLsQEtFsDLWkL P53_TAD X 2529 -CSNK1D CK1D P48730 human Tau iso8 4137 P10636-8 MAPT human S396 449081 GAEIVyKsPVVsGDt X X 9632 -CSNK1D CK1D P48730 human DVL2 13543 Q60838 Dvl2 mouse S592 27623905 HSEGSRssGstRsDG Dsh_C X -CSNK1D CK1D P48730 human Tau iso8 4137 P10636-8 MAPT human S404 449082 PVVsGDtsPRHLsNV X X 35834; 20194; 98523; 91600; 49562 -CSNK1D CK1D P48730 human hnRNP P2 2521 P35637 FUS human S183 1878186706 NYGQDQssMSSGGGS X -CSNK1D CK1D P48730 human HIF2A 2034 Q99814 EPAS1 human S383 59087903 SSGKGAVsEkSNFLF X -CSNK1D CK1D P48730 human MDM2 17246 P23804 Mdm2 mouse S238 454919 GDCLDQDsVsDQFsV X -CSNK1D CK1D P48730 human CTNNB1 1499 P35222 CTNNB1 human S45 447488 GATtTAPsLsGkGNP X 9565; 9564; 24710; 70034; 19807; 96727; 77605 -CSNK1D CK1D P48730 human p53 22059 P02340 Tp53 mouse S12 447538 EEsQsDIsLELPLsQ P53_TAD X X -CSNK1D CK1D P48730 human MDM2 4193 Q00987 MDM2 human S172 17342602 IsEtEENsDELsGER X -CSNK1D CK1D P48730 human LRP6 4040 O75581 LRP6 human S1490 456289 AILNPPPsPAtERsH X 2568 -CSNK1D CK1D P48730 human DCK 1633 P27707 DCK human S11 460585 PPKRsCPsFsAssEG X -CSNK1D CK1D P48730 human TDP-43 23435 Q13148 TARDBP human S317 54023801 GMNFGAFsINPAMMA X -CSNK1D CK1D P48730 human TDP-43 23435 Q13148 TARDBP human S409 3084616 GssMDskssGWGM__ X X -CSNK1D CK1D P48730 human MDM2 17246 P23804 Mdm2 mouse S244 454925 DsVsDQFsVEFEVES X -CSNK1D CK1D P48730 human hnRNP P2 2521 P35637 FUS human S182 1878186704 GNYGQDQssMSSGGG X X -CSNK1D CK1D P48730 human UHRF1 29128 Q96T88 UHRF1 human S95 3210060 sELsDtDsGCCLGQS X X -CSNK1D CK1D P48730 human ATOH1 11921 P48985 Atoh1 mouse S309 57761909 MMAQKDLsPsLPGGI X -CSNK1D CK1D P48730 human MBP 618684 P02687 MBP cow S109 451768 QGKGrGLsLSRFsWG Myelin_MBP X -CSNK1D CK1D P48730 human SMARCA4 6597 P51532 SMARCA4 human S31 1261736700 PGAMLGPsPGPsPGS X X -CSNK1D CK1D P48730 human LZTS2 84445 Q9BRK4 LZTS2 human S220 1871717501 PSGTLSDsGRNsLSS X -CSNK1D CK1D P48730 human hnRNP P2 2521 P35637 FUS human S221 12217071 GGrGrGGsGGGGGGG X -CSNK1D CK1D P48730 human MDM2 4193 Q00987 MDM2 human T365 17342610 DVPDCkktIVNDSRE X -CSNK1D CK1D P48730 human YAP1 10413 P46937 YAP1 human S403 3190675 EstDsGLsMsSySVP X X -CSNK1D CK1D P48730 human Cas-L 4739 Q14511 NEDD9 human T804 348338201 AALHYPStTALQEMV CAS_C X -CSNK1D CK1D P48730 human APC 324 P25054 APC human S1510 999606 sssLsALsLDEPFIQ X -CSNK1D CK1D P48730 human PRKD2 25865 Q9BZL6 PRKD2 human S244 1028300 sssSssAssyTGRPI X X -CSNK1D CK1D P48730 human MDM2 4193 Q00987 MDM2 human S176 17342604 EENsDELsGERQRkR X -CSNK1D CK1D P48730 human SRC-3 8202 Q9Y6Q9 NCOA3 human S601 7596700 SDKESKEsSVEGAEN X X -CSNK1D CK1D P48730 human FOXO1A 84482 G3V7R4 Foxo1 rat S316 449112 PRTSsNAsTIsGRLs X X -CSNK1D CK1D P48730 human MDM2 4193 Q00987 MDM2 human S229 17342601 PDLDAGVsEHSGDWL X -CSNK1D CK1D P48730 human APC 324 P25054 APC human S1504 999604 PDGFsCsssLsALsL APC_r X -CSNK1D CK1D P48730 human MDM2 4193 Q00987 MDM2 human S269 455458 sEEGQELsDEDDEVy X -CSNK1D CK1D P48730 human p53 22059 P02340 Tp53 mouse S7 448716 _MTAMEEsQsDIsLE X X -CSNK1D CK1D P48730 human p53 22059 P02340 Tp53 mouse S9 447537 TAMEEsQsDIsLELP P53_TAD X X 9285 -CSNK1D CK1D P48730 human TOP2B iso2 7155 Q02880-2 TOP2B human S1130 23154509 HDDSSSDsGTPsGPD DNA_topoisoIV X -CSNK1D CK1D P48730 human TDP-43 23435 Q13148 TARDBP human S305 6855916 GLGNNQGsNMGGGMN X -CSNK1D CK1D P48730 human Wee1 7465 P30291 WEE1 human S212 25316778 SVkLRGssLFMDtEK X -CSNK1D CK1D P48730 human hnRNP P2 2521 P35637 FUS human S273 23113764 GGPrDQGsRHDsEQD X -CSNK1D CK1D P48730 human HIF1A 3091 Q16665 HIF1A human S247 15434302 KTFLSRHsLDMkFSY X X -CSNK1D CK1D P48730 human ZNF322A 79692 Q6U7Q0 ZNF322 human S396 114810401 ELsPPHAsEAsQMS_ X -CSNK1D CK1D P48730 human PER2 8864 O15055 PER2 human S662 449331 ALPGKAEsVAsLTsQ X -CSNK1D CK1D P48730 human ATOH1 11921 P48985 Atoh1 mouse S325 57761904 QPVQEDNsKTsPRsH X -CSNK1D CK1D P48730 human DCK 1633 P27707 DCK human T72 4645914 QDEFEELtMsQkNGG dNK X -CSNK1D CK1D P48730 human Tau iso8 4137 P10636-8 MAPT human S202 447928 sGyssPGsPGtPGsR X X 39357; 30505 -CSNK1D CK1D P48730 human hnRNP P2 2521 P35637 FUS human S346 14160213 VsFDDPPsAkAAIDW RRM_1 X -CSNK1D CK1D P48730 human DVL2 1856 O14641 DVL2 human S143 7320089 FHPNVSssHENLEPE Dishevelled X X -CSNK1D CK1D P48730 human TDP-43 23435 Q13148 TARDBP human S410 3084601 ssMDskssGWGM___ X X -CSNK1D CK1D P48730 human ATOH1 11921 P48985 Atoh1 mouse S328 34425604 QEDNsKTsPRsHRsD X -CSNK1D CK1D P48730 human PPP5C 5536 P53041 PPP5C human T362 344893200 LFSEDGVtLDDIRKI Metallophos X X -CSNK1D CK1D P48730 human MDM2 4193 Q00987 MDM2 human S220 17342605 SESTGtPsNPDLDAG X -CSNK1D CK1D P48730 human ATOH1 11921 P48985 Atoh1 mouse S345 57761907 FsPHSHYsDsDEAS_ X -CSNK1D CK1D P48730 human DVL2 13543 Q60838 Dvl2 mouse S597 22682200 RssGstRsDGGAGRT Dsh_C X -CSNK1D CK1D P48730 human MDM2 4193 Q00987 MDM2 human S262 454944 DsEDYsLsEEGQELs X -CSNK1D CK1D P48730 human CDH1 999 P12830 CDH1 human S844 478354 GsGsEAAsLSsLNsS CADH_Y-type_LIR X -CSNK1D CK1D P48730 human DCK 1633 P27707 DCK human S15 460586 sCPsFsAssEGtRIK X -CSNK1D CK1D P48730 human TDP-43 23435 Q13148 TARDBP human S333 54023800 AQAALQSsWGMMGML X -CSNK1D CK1D P48730 human TDP-43 23435 Q13148 TARDBP human S395 6855914 AsNAGsGsGFNGGFG X -CSNK1D CK1D P48730 human MDM2 4193 Q00987 MDM2 human S342 17342606 GkDkGEIsEkAkLEN X -CSNK1D CK1D P48730 human hnRNP P2 2521 P35637 FUS human S462 18801758 PGGGPGGsHMGGNyG X -CSNK1D CK1D P48730 human MDM2 4193 Q00987 MDM2 human S166 448130 SsRRRAIsEtEENsD X 3521 -CSNK1D CK1D P48730 human DVL2 1856 O14641 DVL2 human T224 25538000 MSRFssStEQSsASR Dishevelled X X -CSNK1D CK1D P48730 human TDP-43 23435 Q13148 TARDBP human S403 3084617 GFNGGFGssMDskss X X -CSNK1D CK1D P48730 human hnRNP P2 2521 P35637 FUS human S277 1232880 DQGsRHDsEQDNSDN X -CSNK1D CK1D P48730 human MDM2 17246 P23804 Mdm2 mouse S240 454921 CLDQDsVsDQFsVEF X -CSNK1D CK1D P48730 human MDM2 4193 Q00987 MDM2 human T419 448132 KEFEREEtQDKEEsV X -CSNK1D CK1D P48730 human PER2 8864 O15055 PER2 human S668 20688400 EsVAsLTsQCsYSST X -CSNK1D CK1D P48730 human DCK 1633 P27707 DCK human S74 456305 EFEELtMsQkNGGNV dNK X 40371 -CSNK1D CK1D P48730 human TDP-43 23435 Q13148 TARDBP human S404 3084635 FNGGFGssMDskssG X X -CSNK1D CK1D P48730 human hnRNP P2 2521 P35637 FUS human T338 1878186708 GkLkGEAtVsFDDPP X -CSNK1D CK1D P48730 human PSEN2 5664 P49810 PSEN2 human S330 448567 MEEDsYDsFGEPsYP Presenilin; Presenilin X -CSNK1D CK1D P48730 human p53 7157 P04637 TP53 human S20 447529 PLsQEtFsDLWkLLP P53_TAD X 9287 -CSNK1D CK1D P48730 human MDM2 4193 Q00987 MDM2 human S373 17342608 IVNDSREsCVEENDD X -CSNK1D CK1D P48730 human CTNNB1 12387 Q02248 Ctnnb1 mouse S47 34606438 TtTAPsLsGkGNPEE X -CSNK1D CK1D P48730 human ATOH1 11921 P48985 Atoh1 mouse S334 57761903 TsPRsHRsDGEFsPH X -CSNK1D CK1D P48730 human TDP-43 23435 Q13148 TARDBP human S389 6855917 AIGWGsAsNAGsGsG X -CSNK1D CK1D P48730 human Cas-L 4739 Q14511 NEDD9 human S780 348338200 RNkVMNSsNQLCEQL CAS_C X -CSNK1D CK1D P48730 human FOXO1A 84482 G3V7R4 Foxo1 rat S319 449114 SsNAsTIsGRLsPIM X X -CSNK1D CK1D P48730 human MDM2 4193 Q00987 MDM2 human S290 17342600 AGEsDtDsFEEDPEI X -CSNK1D CK1D P48730 human YAP1 iso2 10413 P46937-2 YAP1 human S384 9764918 SRDEsTDsGLsMSSY X -CSNK1D CK1D P48730 human MDM2 4193 Q00987 MDM2 human S118 15714603 NQQESSDsGTsVSEN X -CSNK1D CK1D P48730 human TDP-43 23435 Q13148 TARDBP human S292 6855918 NQGGFGNsrGGGAGL X -CSNK1D CK1D P48730 human PER2 8864 O15055 PER2 human S665 470017 GKAEsVAsLTsQCsY X -CSNK1D CK1D P48730 human LZTS2 84445 Q9BRK4 LZTS2 human S277 1871717500 HsDsGRsssSKsTGS X -CSNK1D CK1D P48730 human TDP-43 23435 Q13148 TARDBP human S92 6855902 MDEtDAssAVkVKRA X -CSNK1D CK1D P48730 human APC 324 P25054 APC human S1505 452096 DGFsCsssLsALsLD APC_r X -CSNK1D CK1D P48730 human FMR1 14265 P35922 Fmr1 mouse S499 469583 NSEAsNAsETESDHR FXMRP1_C_core X -CSNK1D CK1D P48730 human DVL2 13543 Q60838 Dvl2 mouse S591 27623904 QHSEGSRssGstRsD Dsh_C X -CSNK1D CK1D P48730 human MTSS1 9788 O43312 MTSS1 human S322 4763951 SSVsSHDsGFISQDA X -CSNK1D CK1D P48730 human MDM2 4193 Q00987 MDM2 human S253 2132107 sVEFEVEsLDsEDYs X -CSNK1D CK1D P48730 human FGFBP1 281812 Q9MZ06 FGFBP1 cow S36 487543 NRRGSKAsADESLAL FGF-BP1 X -CSNK1D CK1D P48730 human KIR3DL1 3811 P43629 KIR3DL1 human S388 990303 RTANsEDsDEQDPEE X -CSNK1D CK1D P48730 human PSEN2 5664 P49810 PSEN2 human S327 448564 DPEMEEDsYDsFGEP Presenilin; Presenilin X -CSNK1D CK1D P48730 human hnRNP P2 2521 P35637 FUS human S164 1878186702 QQNQYNssSGGGGGG X -CSNK1D CK1D P48730 human MDM2 4193 Q00987 MDM2 human S121 15714602 ESSDsGTsVSENRCH X X -CSNK1D CK1D P48730 human Tau iso8 4137 P10636-8 MAPT human T205 447933 ssPGsPGtPGsRsRt X X 25377; 43964; 53001; 49561; 20060; 33032; 30505; 20739; 98160 -CSNK1D CK1D P48730 human KIR3DL1 3811 P43629 KIR3DL1 human S385 990304 AGNRTANsEDsDEQD X -CSNK1D CK1D P48730 human ATOH1 11921 P48985 Atoh1 mouse S331 57761908 NsKTsPRsHRsDGEF X -CSNK1D CK1D P48730 human MDM2 4193 Q00987 MDM2 human S240 454919 GDWLDQDsVsDQFsV X -CSNK1D CK1D P48730 human MDM2 4193 Q00987 MDM2 human T279 17342603 DDEVyQVtVyQAGEs X -Map3k3 MEKK3 Q61084 mouse MKK3 5606 P46734 MAP2K3 human S218 448276 IsGyLVDsVAKtMDA Pkinase X 9231; 9236; 12280 -Map3k3 MEKK3 Q61084 mouse p47phox 17969 Q09014 Ncf1 mouse S208 465580 KRGWVPAsYLEPLDS X -MKNK1 Mnk1 iso2 Q9BUB5-2 human EIF4E 1977 P06730 EIF4E human S209 447776 DtATksGsttKNRFV X 9741 -Prkcq PKCT Q02111 mouse PDK1 18607 Q9Z2A0 Pdpk1 mouse S532 5938009 TYYLMDPsGNAHKWC PH_3 X -Prkcq PKCT Q02111 mouse PKCT 5588 Q04759 PRKCQ human T219 457380 SAINSREtMFHkERF X -Prkcq PKCT Q02111 mouse NDRG2 29811 Q9QYG0 Ndrg2 mouse S332 451010 LsRsRtAsLtsAAsI X -Prkcq PKCT Q02111 mouse SRC-1 17977 P70365 Ncoa1 mouse S1271 396518803 MPVPPPQssLLQQTP DUF1518 X -Prkcq PKCT Q02111 mouse PDK1 18607 Q9Z2A0 Pdpk1 mouse S504 5938008 LKGEIPWsQELRPEA PH_3 X -Prkcq PKCT Q02111 mouse Radixin 19684 P26043 Rdx mouse T564 448374 AGRDKYKtLRQIRQG ERM_C X 3141; 3726; 32600 -Prkcq PKCT Q02111 mouse sialophorin 20737 P15702 Spn mouse S347 477870 RRKsRQGsLVLEELK X -Prkcq PKCT Q02111 mouse SRC-1 17977 P70365 Ncoa1 mouse S1272 396518804 PVPPPQssLLQQTPP DUF1518 X -Prkcq PKCT Q02111 mouse IRS1 3667 P35568 IRS1 human S1101 453434 GCRRRHssEtFsStP X X -Prkcq PKCT Q02111 mouse IRS1 16367 P35569 Irs1 mouse S1097 453434 GCRRRHssEtFSAPt X 2385 -Prkcq PKCT Q02111 mouse KLF1 16596 P46099 Klf1 mouse S50 31953300 PPNPTGPsLHVSLkS X X -Prkcq PKCT Q02111 mouse CD4 12504 P06332 Cd4 mouse S432 451188 QRQAARMsQIKRLLS Tcell_CD4_C X -Prkcq PKCT Q02111 mouse NDRG2 171114 Q8VBU2 Ndrg2 rat S332 451010 LsRsRtAsLtsAAsI X -HSPA5 GRP78 P11021 human GRP78 3309 P11021 HSPA5 human T229 2876500 VFDLGGGtFDVSLLT HSP70 X -KSR2 KSR2 Q6VAB6 human MEK1 100009316 P29678 MAP2K1 rabbit S24 20910000 GSAVNGTsSAETNLE X -KSR2 KSR2 Q6VAB6 human MEK1 100009316 P29678 MAP2K1 rabbit S72 448585 DDDFEKIsELGAGNG Pkinase X -KSR2 KSR2 Q6VAB6 human MEK1 100009316 P29678 MAP2K1 rabbit S218 448514 VSGQLIDsMANsFVG Pkinase X 9121; 3958; 9154; 86128 -KSR2 KSR2 Q6VAB6 human MEK1 100009316 P29678 MAP2K1 rabbit S222 448513 LIDsMANsFVGTRSY Pkinase X 2338; 9121; 3958; 9154; 16211; 86128; 16780; 75262 -Pdgfrb PDGFRB Q05030 rat PDGFRB Q05030 Pdgfrb rat Y1020 447523 PNETDNDyIIPLPDP X -Pdgfrb PDGFRB Q05030 rat PDGFRB Q05030 Pdgfrb rat Y578 447521 VSSDGHEyIYVDPVQ X -Pdgfrb PDGFRB Q05030 rat PDGFRB Q05030 Pdgfrb rat Y750 447508 SKDESVDyVPMLDMK PK_Tyr_Ser-Thr X -Pdgfrb PDGFRB Q05030 rat PDGFRB Q05030 Pdgfrb rat Y715 447524 CPPSTELySNALPVG PK_Tyr_Ser-Thr X -Camk2b CAMK2B P08413 rat GSK3B 84027 P18266 Gsk3b rat S9 449111 SGRPRTTsFAESCKP X 9336; 9331; 9327; 9323; 9322; 9325; 5558; 8566; 79774; 8466; 25462; 14026; 14332; 14310; 14630 -Camk2b CAMK2B P08413 rat CAMK2A 25400 P11275 Camk2a rat T286 447797 sCMHRQEtVDCLkkF X 12716 -Camk2b CAMK2B P08413 rat SAPAP1 65040 P97836 Dlgap1 rat S389 481511 YLKATQPsLTELTTL X -Camk2b CAMK2B P08413 rat CAMK2B 24245 P08413 Camk2b rat S327 48915806 ttAPAtMstAAsGtt X -Camk2b CAMK2B P08413 rat CAMK2B 24245 P08413 Camk2b rat T400 2030268 EssDsTNttIEDEDA X -Camk2b CAMK2B P08413 rat CAMK2B 24245 P08413 Camk2b rat T287 450048 sMMHRQEtVECLkkF X X 12716 -Camk2b CAMK2B P08413 rat Spinophilin 84686 O35274 Ppp1r9b rat S100 448729 LsLPRAssLNENVDH X -Camk2b CAMK2B P08413 rat CAMK2B 24245 P08413 Camk2b rat T307 2020797 LkGAILttMLAtRNF X -Camk2b CAMK2B P08413 rat SAPAP1 65040 P97836 Dlgap1 rat S691 12130200 KTSSKFQsVGVQVEE GKAP X -Camk2b CAMK2B P08413 rat CAMK2B 24245 P08413 Camk2b rat T382 48915804 AALEPQttVIHNPVD X -Camk2b CAMK2B P08413 rat SynGAP 192117 Q9QUH6 Syngap1 rat S1118 481550 kEGsIGGsGGsGGGG DUF3498 X -Camk2b CAMK2B P08413 rat AMPKA1 65248 P54645 Prkaa1 rat T183 448786 SDGEFLRtsCGSPNY Pkinase X 2535; 2531; 4188; 5256; 50081; 74281 -Camk2b CAMK2B P08413 rat CAMK2B 24245 P08413 Camk2b rat T254 2048065 NLINQMLtINPAkRI Pkinase X -Camk2b CAMK2B P08413 rat CAMK2B 24245 P08413 Camk2b rat T334 48915802 stAAsGttMGLVEQA X -Camk2b CAMK2B P08413 rat CAMK2B 24245 P08413 Camk2b rat S371 2020829 AITsPkGsLPPAALE X X -Camk2b CAMK2B P08413 rat CAMK2B 24245 P08413 Camk2b rat T311 15719513 ILttMLAtRNFsVGR X -Camk2b CAMK2B P08413 rat CAMK2B 24245 P08413 Camk2b rat S363 3558927 TNsTkNSsAITsPkG X -Camk2b CAMK2B P08413 rat SynGAP 192117 Q9QUH6 Syngap1 rat S1121 481551 sIGGsGGsGGGGGGG DUF3498 X -Camk2b CAMK2B P08413 rat SAPAP3 286923 P97838 Dlgap3 rat S930 481288 GVPVKERsLDsVDRQ GKAP X -Camk2b CAMK2B P08413 rat SHANK3 59312 Q9JLU4 Shank3 rat S1511 2048965 QLNKDTRsLGEEPVG X -Camk2b CAMK2B P08413 rat SynGAP 192117 Q9QUH6 Syngap1 rat S766 4792737 MMRDLNssIDLQSFM DUF3498 X -Camk2b CAMK2B P08413 rat CAMK2B 24245 P08413 Camk2b rat T320 48915800 NFsVGRQttAPAtMs X -Camk2b CAMK2B P08413 rat CAMK2B 24245 P08413 Camk2b rat S343 7446037 GLVEQAksLLNkkAD X -Camk2b CAMK2B P08413 rat CAMK2A 25400 P11275 Camk2a rat S314 451708 MLAtRNFsGGKSGGN X -Camk2b CAMK2B P08413 rat CDC20 64515 Q62623 Cdc20 rat S51 20653800 RAANRSHsAGRTPGR X X 8038 -Camk2b CAMK2B P08413 rat CAMK2A 25400 P11275 Camk2a rat T253 451571 DLINkMLtINPskRI Pkinase X -Camk2b CAMK2B P08413 rat LRRC7 117284 P70587 Lrrc7 rat S1392 481330 IQTKGQRsMDGYPEQ X -Camk2b CAMK2B P08413 rat CAMK2B 24245 P08413 Camk2b rat S315 451707 MLAtRNFsVGRQttA X -Camk2b CAMK2B P08413 rat CAMK2B 24245 P08413 Camk2b rat T381 2020833 PAALEPQttVIHNPV X -Camk2b CAMK2B P08413 rat CAMK2B 24245 P08413 Camk2b rat T401 4705443 ssDsTNttIEDEDAK X -Camk2b CAMK2B P08413 rat CAMK2B 24245 P08413 Camk2b rat T325 48915805 RQttAPAtMstAAsG X -Camk2b CAMK2B P08413 rat CAMK2B 24245 P08413 Camk2b rat T328 34358436 tAPAtMstAAsGttM X -Camk2b CAMK2B P08413 rat CAMK2B 24245 P08413 Camk2b rat S280 4705429 CQRstVAsMMHRQEt X -Camk2b CAMK2B P08413 rat LRRC7 117284 P70587 Lrrc7 rat T827 12157800 PLELEQstHRHtPET X -Camk2b CAMK2B P08413 rat CAMK2B 24245 P08413 Camk2b rat S331 48915803 AtMstAAsGttMGLV X X -Camk2b CAMK2B P08413 rat SHANK3 59312 Q9JLU4 Shank3 rat S694 2022961 TLTLRSKsMTAELEE X -Camk2b CAMK2B P08413 rat Spinophilin 84686 O35274 Ppp1r9b rat S99 2023901 RLsLPRAssLNENVD X -Camk2b CAMK2B P08413 rat CAMK2B 24245 P08413 Camk2b rat T321 2048069 FsVGRQttAPAtMst X -Camk2b CAMK2B P08413 rat CAMK2B 24245 P08413 Camk2b rat T306 451706 kLkGAILttMLAtRN X -Camk2b CAMK2B P08413 rat SynGAP 192117 Q9QUH6 Syngap1 rat S1073 469613 PPLQRGKsQQLTVsA DUF3498 X -Camk2b CAMK2B P08413 rat CAMK2B 24245 P08413 Camk2b rat T333 48915801 MstAAsGttMGLVEQ X -Camk2b CAMK2B P08413 rat SynGAP 192117 Q9QUH6 Syngap1 rat S765 4792731 yMMRDLNssIDLQSF DUF3498 X -Camk2b CAMK2B P08413 rat SAPAP2 116681 P97837 Dlgap2 rat S1012 2049577 FPITREKsLDLPDRQ GKAP X -Camk2b CAMK2B P08413 rat LRRC7 117284 P70587 Lrrc7 rat S826 2049457 VPLELEQstHRHtPE X -Camk2b CAMK2B P08413 rat GSK3A 50686 P18265 Gsk3a rat S21 448584 SGRARtssFAEPGGG X 9337; 9316; 9331; 9327; 8452; 8566 -Camk2b CAMK2B P08413 rat SAPAP1 65040 P97836 Dlgap1 rat S947 481515 APLIRERsLESSQRQ GKAP X -Camk2b CAMK2B P08413 rat CAMK2B 24245 P08413 Camk2b rat S397 485905 GIKEssDsTNttIED X -Camk2b CAMK2B P08413 rat SHANK1 78957 Q9WV48 Shank1 rat S783 12130201 RLPPPAIsLRSKSMT X -Camk2b CAMK2B P08413 rat CAMK2B 24245 P08413 Camk2b rat S367 456904 kNSsAITsPkGsLPP X -Camk2b CAMK2B P08413 rat SynGAP 192117 Q9QUH6 Syngap1 rat S1114 481549 QsLSkEGsIGGsGGs DUF3498 X -Camk2b CAMK2B P08413 rat CAMK2B 24245 P08413 Camk2b rat S358 15719516 GVkPQTNsTkNSsAI X -Csnk1d CK1D Q06486 rat DARPP-32 360616 Q6J4I0 Ppp1r1b rat S137 448046 EEDEEEDsQAEVLKG DARPP-32 X -Csnk1d CK1D Q06486 rat DARPP-32 360616 Q6J4I0 Ppp1r1b rat T34 448047 MIRRRRPtPALLFRV DARPP-32 X 12438 -Irak1 IRAK1 Q62406 mouse IRAK1BP1 65099 Q9ESJ7 Irak1bp1 mouse S234 12524610 TVQQKIKsAtIHAAs SIMPL X -Irak1 IRAK1 Q62406 mouse STAT3 20848 P42227 Stat3 mouse S727 448191 NtIDLPMsPRTLDSL X 9134; 9136; 34911; 94994; 49081; 58978; 87544; 71958; 50804 -Irak1 IRAK1 Q62406 mouse IRAK1BP1 65099 Q9ESJ7 Irak1bp1 mouse S63 12524608 GAAEVsAsPDRALVT SIMPL X -Irak1 IRAK1 Q62406 mouse IRAK1BP1 65099 Q9ESJ7 Irak1bp1 mouse T236 12524611 QQKIKsAtIHAAsKV SIMPL X -Irak1 IRAK1 Q62406 mouse IRAK1BP1 65099 Q9ESJ7 Irak1bp1 mouse T246 12524605 AAsKVFItFEVKGKE SIMPL X -Irak1 IRAK1 Q62406 mouse IRAK1BP1 65099 Q9ESJ7 Irak1bp1 mouse S61 12524607 VsGAAEVsAsPDRAL SIMPL X -Irak1 IRAK1 Q62406 mouse IRAK1BP1 65099 Q9ESJ7 Irak1bp1 mouse S55 12524606 GAREVHVsGAAEVsA SIMPL X -Irak1 IRAK1 Q62406 mouse IRAK1BP1 65099 Q9ESJ7 Irak1bp1 mouse S241 12524609 sAtIHAAsKVFItFE SIMPL X -PDK4 PDHK4 Q16654 human PDHA1 5160 P08559 PDHA1 human S300 448259 sMsDPGVsyRtREEI E1_dh X -PDK4 PDHK4 Q16654 human PDHA1 18597 P35486 Pdha1 mouse S293 448258 TYRyHGHsMsDPGVs E1_dh X 31866; 37115; 48447 -PDK4 PDHK4 Q16654 human PDHA1 18597 P35486 Pdha1 mouse S300 448259 sMsDPGVsyRtREEI E1_dh X -PDK4 PDHK4 Q16654 human PDHA1 5160 P08559 PDHA1 human S293 448258 TYRyHGHsMsDPGVs E1_dh X X 31866; 37115; 48447 -PDK4 PDHK4 Q16654 human PDHA2 5161 P29803 PDHA2 human S298 458870 sMsDPGVsyRtREEI E1_dh X -PDK4 PDHK4 Q16654 human myogenin 17928 P12979 Myog mouse T57 1880114102 LEEKGLGtPEHCPGQ X -PDK4 PDHK4 Q16654 human PDHA1 5160 P08559 PDHA1 human S232 448257 NRyGMGtsVERAAAs E1_dh X 15289 -PDK4 PDHK4 Q16654 human PDHA2 5161 P29803 PDHA2 human S291 458869 TYRyHGHsMsDPGVs E1_dh X 31866; 37115; 48447 -PDK4 PDHK4 Q16654 human myogenin 17928 P12979 Myog mouse S43 1880114100 ERTELSLsPEARGPL X -PLK4 PLK4 O00444 human HAND1 15110 Q64279 Hand1 mouse T107 12518701 PKKERRRtEsINSAF HLH X -PLK4 PLK4 O00444 human NEDD1 121441 Q8NHV4 NEDD1 human S338 25533005 AsGGVQNsGIVREAP X X -PLK4 PLK4 O00444 human PLK4 10733 O00444 PLK4 human T170 480636 MPHEkHYtLCGtPNy Pkinase X -PLK4 PLK4 O00444 human PLK4 10733 O00444 PLK4 human S305 12122401 sstsIsGsLFDKRRL X X -PLK4 PLK4 O00444 human CENPJ 55835 Q9HC77 CENPJ human S595 14918201 IsFSSNSsFVLKILE X X -PLK4 PLK4 O00444 human HAND1 15110 Q64279 Hand1 mouse S109 12518702 KERRRtEsINSAFAE HLH X -PLK4 PLK4 O00444 human NEDD1 121441 Q8NHV4 NEDD1 human S404 25533002 sFDDtGKssLGDMFs X X -PLK4 PLK4 O00444 human CEP131 22994 Q9UPN4 CEP131 human S78 1211822 NNLRRsNsttQVSQP X X -PLK4 PLK4 O00444 human STIL 6491 Q15468 STIL human S428 1868450205 QPSVPELsLVLDGNF STIL_N X X -PLK4 PLK4 O00444 human NEDD1 121441 Q8NHV4 NEDD1 human S325 15421692 PTTVNKRsVNVNAAs X X -PLK4 PLK4 O00444 human PCM-1 5108 Q15154 PCM1 human S372 11536118 RRQAEsLsLtREVsQ X -PLK4 PLK4 O00444 human NEDD1 121441 Q8NHV4 NEDD1 human T23 1871432200 IWDASSMtLVDKFNP WD40 X X -PLK4 PLK4 O00444 human NEDD1 121441 Q8NHV4 NEDD1 human T303 1871432201 CIAFQYStVLTKSSL X X -PLK4 PLK4 O00444 human PLK4 10733 O00444 PLK4 human S22 21691605 GNLLGKGsFAGVYRA Pkinase X -PLK4 PLK4 O00444 human ARP2 10097 P61160 ACTR2 human T238 36440501 QKLALEttVLVESYT Actin X X -PLK4 PLK4 O00444 human PLK4 10733 O00444 PLK4 human Y177 21691606 tLCGtPNyISPEIAT Pkinase X -PLK4 PLK4 O00444 human CEP131 22994 Q9UPN4 CEP131 human T205 1868722300 PLkSSNQtAPsLNNI X -PLK4 PLK4 O00444 human NEDD1 121441 Q8NHV4 NEDD1 human S568 25533011 AGVAssLsEkIADsI X X -PLK4 PLK4 O00444 human FBXW5 54461 Q969U6 FBXW5 human S151 20831310 SQFNKDDsLLLASGV X X -PLK4 PLK4 O00444 human NEK7 140609 Q8TDX7 NEK7 human S204 3207291 VGtPyyMsPERIHEN Pkinase X -PLK4 PLK4 O00444 human ARP2 10097 P61160 ACTR2 human T237 36440502 EQKLALEttVLVESY Actin X X -PLK4 PLK4 O00444 human PPP1R16B 26051 Q96T49 PPP1R16B human S69 17549547 KKVSFEAsVALLEAS X -PLK4 PLK4 O00444 human STIL 6491 Q15468 STIL human S1116 17400758 LIsPNNMsFAtkKYM X X -PLK4 PLK4 O00444 human CP110 9738 O43303 CCP110 human S98 126835300 VRKAPNAsDFDQWEM CaM_bind X X -PLK4 PLK4 O00444 human CEP131 22994 Q9UPN4 CEP131 human S21 41451326 sPAGVDLsLTGLPPP X X -Mark4 MARK4 Q8CIP4 mouse MAP4 17758 P27546 Map4 mouse S1046 470381 KAQAKVGsLDNVGHL Tubulin-binding X -Mark4 MARK4 Q8CIP4 mouse MAP4 17758 P27546 Map4 mouse S914 1210622 SVRsKVGstENIKHQ Tubulin-binding X -Tbk1 TBK1 NP_001100256 rat EXOC8 245709 O54924 Exoc8 rat S28 480112 RLYVKQLsQQsDGDR Vps51 X -Tbk1 TBK1 NP_001100256 rat SQSTM1 113894 O08623 Sqstm1 rat S402 22264800 ESLSQMLsMGFSDEG UBA_5 X 39786 -Tbk1 TBK1 NP_001100256 rat EXOC8 245709 O54924 Exoc8 rat S670 56663140 TFIRQNAsFLyDTVL X -Tbk1 TBK1 NP_001100256 rat EXOC8 245709 O54924 Exoc8 rat T313 454459 EAEEELAtPEAEEEK X -Tbk1 TBK1 NP_001100256 rat EXOC8 245709 O54924 Exoc8 rat S92 182950100 HLLTEQKssLESIPL Vps51 X -Tbk1 TBK1 NP_001100256 rat EXOC8 245709 O54924 Exoc8 rat S93 182950101 LLTEQKssLESIPLA Vps51 X -Tbk1 TBK1 NP_001100256 rat EXOC8 245709 O54924 Exoc8 rat S31 40510667 VKQLsQQsDGDRDLQ Vps51 X -Tbk1 TBK1 NP_001100256 rat EXOC8 245709 O54924 Exoc8 rat S366 182950104 EDKPSPPsVKELRAK Exo84_C X -Tbk1 TBK1 NP_001100256 rat EXOC8 245709 O54924 Exoc8 rat S505 25291117 QVFDSKEsLSTAAEC Exo84_C X -Tbk1 TBK1 NP_001100256 rat INSR 24954 P15127 Insr rat S1034 454090 LRELGQGsFGMVYEG PK_Tyr_Ser-Thr X -Tbk1 TBK1 NP_001100256 rat EXOC8 245709 O54924 Exoc8 rat S276 182950103 EETKRALsDKRRREQ X -Tbk1 TBK1 NP_001100256 rat EXOC8 245709 O54924 Exoc8 rat T152 182950102 GEEGKQRtLTTLLEK X -CIT CRIK O14578 human GLI2 2736 P10070 GLI2 human S149 10414536 IsAArGLsPADVAQE X -CIT CRIK O14578 human MRLC1 296313 Q64122 Myl9 rat S20 1863500 KRPQSAtsNVFAMFD X 3674; 3671; 3675; 95777 -CIT CRIK O14578 human MRLC1 10398 P24844 MYL9 human T19 1863501 KKRPQRAtsNVFAMF X 3674; 95777 -CIT CRIK O14578 human MRLC1 296313 Q64122 Myl9 rat T19 1863501 KKRPQSAtsNVFAMF X 3674; 95777 -CIT CRIK O14578 human MRLC1 10398 P24844 MYL9 human S20 1863500 KRPQRAtsNVFAMFD X 3674; 3671; 3675; 95777 -Flt3 FLT3 Q00342 mouse FLT3 14255 Q00342 Flt3 mouse Y592 448190 PLDNEyFyVDFRDYE X 3466; 3461; 3464 -AURKC AurC Q9UQB9 human H3 8350 P68431 H3C1 human S10 455676 tkQtArkstGGkAPr Histone X 9701; 9711; 9606; 3465; 3642; 3377; 3475; 3458; 5764; 47398; 8481; 8552; 53348; 29237; 66065; 43185; 64522; 52725 -AURKC AurC Q9UQB9 human IkB-alpha 4792 P25963 NFKBIA human S262 1873119302 QLTWGRPsTRIQQQL X X -AURKC AurC Q9UQB9 human AurC 20871 O88445 Aurkc mouse T171 455456 TPSLRRKtMCGtLDY Pkinase X 2914; 13464; 8525 -AURKC AurC Q9UQB9 human IkB-alpha 4792 P25963 NFKBIA human S32 448203 LLDDRHDsGLDsMkD X X 5210; 2859; 9246; 5209 -AURKC AurC Q9UQB9 human INCENP 3619 Q9NQS7 INCENP human S894 450468 RYHKRtssAVWNsPP X -AURKC AurC Q9UQB9 human Survivin 332 O15392 BIRC5 human S20 485776 FLkDHRIstFkNWPF BIR X -AURKC AurC Q9UQB9 human TACC1 6867 O75410 TACC1 human S228 10407015 ELVPsRRsKLRKPkP X -AURKC AurC Q9UQB9 human INCENP 3619 Q9NQS7 INCENP human T892 450466 KPRYHKRtssAVWNs X -AURKC AurC Q9UQB9 human IkB-alpha 4792 P25963 NFKBIA human S63 1873119300 PQEVPRGsEPWkQQL X X -AURKC AurC Q9UQB9 human INCENP 16319 Q9WU62 Incenp mouse S862 450468 RYHKRtssAVWNsPP X -AURKC AurC Q9UQB9 human INCENP 3619 Q9NQS7 INCENP human S893 450467 PRYHKRtssAVWNsP X -AURKC AurC Q9UQB9 human INCENP 16319 Q9WU62 Incenp mouse S861 450467 TRYHKRtssAVWNsP X -PRKCB PKCB P05126-2 cow MARCKS 613548 P12624 MARCKS cow S162 447787 KRFsFKKsFKLsGFs MARCKS X 11992 -PRKCB PKCB P05126-2 cow TOP2A 7153 P11388 TOP2A human T1343 448763 FsDFDEKtDDEDFVP X -PRKCB PKCB P05126-2 cow MARCKS 613548 P12624 MARCKS cow S169 451837 sFKLsGFsFKKNKKE MARCKS X 8722 -PRKCB PKCB P05126-2 cow GJA1 24392 P08050 Gja1 rat S368 447813 QRPssRAssRAssRP X 3511; 52559 -PRKCB PKCB P05126-2 cow MARCKS 613548 P12624 MARCKS cow S158 447786 KKKKKRFsFKKsFKL MARCKS X 11992 -Brsk1 BRSK1 Q5RJI5 mouse ERC2 259269 Q8K3M6 Erc2 rat S45 4740442 GGTGKTLsMENIQSL X -MAP2K7 MKK7 O14733 human JNK3 iso2 5602 P53779-2 MAPK10 human T221 448034 AGTSFMMtPyVVTRY Pkinase X -MAP2K7 MKK7 O14733 human JNK2 5601 P45984 MAPK9 human T183 447649 ACtNFMMtPyVVtRY Pkinase X X -MAP2K7 MKK7 O14733 human JNK1 5599 P45983 MAPK8 human Y185 447645 tsFMMtPyVVtRYYR Pkinase X X 5136; 4668; 4671; 9257; 9255; 9251; 4306; 5755; 16014; 58328 -MAP2K7 MKK7 O14733 human JNK2 26420 Q9WTU6 Mapk9 mouse T183 447649 ACTNFMMtPyVVtRY Pkinase X -MAP2K7 MKK7 O14733 human JNK2 26420 Q9WTU6 Mapk9 mouse Y185 447652 TNFMMtPyVVtRYYR Pkinase X -MAP2K7 MKK7 O14733 human JNK2 5601 P45984 MAPK9 human S407 447648 STEQtLAsDTDSSLD X -MAP2K7 MKK7 O14733 human JNK1 5599 P45983 MAPK8 human T183 447643 AGtsFMMtPyVVtRY Pkinase X X 5136; 4668; 4671; 9257; 9255; 9251; 4306; 5755; 16014; 58328 -MAP2K7 MKK7 O14733 human FADD 8772 Q13158 FADD human S194 447653 QNRsGAMsPMsWNsD X 2781 -MAP2K7 MKK7 O14733 human JNK2 5601 P45984 MAPK9 human T404 447650 SSMSTEQtLAsDTDS X -MAP2K7 MKK7 O14733 human JNK1 iso2 5599 P45983-2 MAPK8 human T183 447643 AGTSFMMtPyVVTRY Pkinase X 5136; 9255; 9251; 4306; 5755; 16014 -MAP2K7 MKK7 O14733 human JNK3 5602 P53779 MAPK10 human T221 448034 AGtsFMMtPyVVtRY Pkinase X 4668; 58328 -Tnni3k TNNI3K Q7TQP6 rat TNNI3 29248 P23693 Tnni3 rat S43 450690 AKKKSKIsAsRKLQL X -Tnni3k TNNI3K Q7TQP6 rat TNNI3 29248 P23693 Tnni3 rat T144 451483 RGKFkRPtLRRVRIs Troponin X -FRK FRK P42685 human YAP1 10413 P46937 YAP1 human Y407 473004 sGLsMsSySVPRtPD X -FRK FRK P42685 human BRCA1 672 P38398 BRCA1 human Y1552 50684000 HDLtEtSyLPRQDLE X X -FRK FRK P42685 human YAP1 10413 P46937 YAP1 human Y444 54390605 QQNRFPDyLEAIPGT X -FRK FRK P42685 human YAP1 10413 P46937 YAP1 human Y391 15565111 PFLNsGtyHSRDEst X -FRK FRK P42685 human Fos 14281 P01101 Fos mouse T232 448491 GGLPEAStPESEEAF X -FRK FRK P42685 human PTEN 5728 P60484 PTEN human Y336 7596704 NKDkANRyFSPNFKV PTEN_C2 X -PIK3CD PIK3CD O00329 human PIK3CD 5293 O00329 PIK3CD human S1039 466429 NWLAHNVsKDNRQ__ X -STK16 MPSK1 O75716 human sarcolipin 100009246 P42532 SLN rabbit T5 459214 ___MERStRELCLNF Sarcolipin X -STK16 MPSK1 O75716 human MPSK1 8576 O75716 STK16 human S197 2028406 AAQRCTIsyRAPELF Pkinase X -STK16 MPSK1 O75716 human MPSK1 8576 O75716 STK16 human Y198 2028407 AQRCTIsyRAPELFS Pkinase X X -STK16 MPSK1 O75716 human MPSK1 8576 O75716 STK16 human T185 2028405 EGSRQALtLQDWAAQ Pkinase X -STK16 MPSK1 O75716 human DRG1 4733 Q9Y295 DRG1 human T101 2028404 yEFTTLTtVPGVIRY MMR_HSR1 X -Pak1 PAK1 O88643 mouse ARPC1B 10095 O15143 ARPC1B human T21 10349703 HAWNkDRtQIAICPN X -Pak1 PAK1 O88643 mouse LC8 56455 P63168 Dynll1 mouse S88 454241 VAILLFKsG______ Dynein_light X X -Pak1 PAK1 O88643 mouse Vimentin 7431 P08670 VIM human S66 451765 GVyAtrssAVrLrss Filament_head X -Pak1 PAK1 O88643 mouse Vimentin 7431 P08670 VIM human S51 449416 LrPstsrsLyAssPG Filament_head X X -Pak1 PAK1 O88643 mouse STAT5A 20850 P42230 Stat5a mouse S779 448750 DsLDARLsPPAGLFT X X -Pak1 PAK1 O88643 mouse FLNA 192176 Q8BTM8 Flna mouse S2152 451357 TRRRRAPsVANIGsH Filamin X 4761 -Pak1 PAK1 O88643 mouse PAK1 18479 O88643 Pak1 mouse S21 448174 APPMRNTsTMIGAGS X -Pak1 PAK1 O88643 mouse Vimentin 7431 P08670 VIM human S73 449025 sAVrLrssVPGVRLL Filament_head X X -Pak1 PAK1 O88643 mouse Vimentin 7431 P08670 VIM human S39 451766 ttstrtysLGsALrP Filament_head X 13614 -Pak1 PAK1 O88643 mouse Vimentin 7431 P08670 VIM human S26 451767 GtAsrPsssrsyVtt Filament_head X -SLK SLK Q9H2G2 human Radixin 5962 P35241 RDX human T564 448374 AGRDKyKtLRQIRQG ERM_C X 3141; 3726; 32600 -SLK SLK Q9H2G2 human Ezrin 7430 P15311 EZR human T567 448104 QGRDkyKtLRQIRQG ERM_C X 3141; 3726; 32600 -SLK SLK Q9H2G2 human SLK 9748 Q9H2G2 SLK human T183 1211366 VsAkNtRtIQRRDsF Pkinase X -SLK SLK Q9H2G2 human PXN 19303 Q8VI36 Pxn mouse S250 3653284 SsPQRVTsSQQQTRI Paxillin X -SLK SLK Q9H2G2 human Moesin 4478 P26038 MSN human T558 447706 LGRDKyKtLRQIRQG ERM_C X 3141; 3726; 32600 -SLK SLK Q9H2G2 human SLK 9748 Q9H2G2 SLK human S189 468769 RtIQRRDsFIGtPyW Pkinase X -CDK16 CDK16 Q00536 human PKAR1A 5573 P10644 PRKAR1A human S83 450936 DsREDEIsPPPPNPV X X -CDK16 CDK16 Q00536 human PRC1 9055 O43663 PRC1 human T481 483541 RrGLAPNtPGkARkL X X -CDK16 CDK16 Q00536 human NSF 18195 P46460 Nsf mouse S569 460358 FPFIKICsPDKMIGF AAA X -CDK16 CDK16 Q00536 human p27Kip1 1027 P46527 CDKN1B human S10 447874 NVRVSNGsPsLErMD X X -CDK16 CDK16 Q00536 human CBCP1 219771 Q8ND76 CCNY human S336 41655502 NLtLPRWsPAIIS__ X -Map3k2 MEKK2 Q61083 mouse MEKK2 26405 Q61083 Map3k2 mouse T283 28761201 EYNDGRKtFPRARRT X -Map3k2 MEKK2 Q61083 mouse CTNNB1 12387 Q02248 Ctnnb1 mouse S675 457120 QDykKRLsVELtSsL X 9567; 4176; 68076 -Map3k2 MEKK2 Q61083 mouse MEKK2 26405 Q61083 Map3k2 mouse S520 1869000 LsGtGMKsVTGTPYW Pkinase X -Sgk1 SGK1 Q06226 rat SRF 501099 NP_001102772 Srf rat S99 447692 RGLKRSLsEMELGVV X -Sgk1 SGK1 Q06226 rat SRF 501099 NP_001102772 Srf rat S75 451803 AGALYsGsEGDSESG X -Sgk1 SGK1 Q06226 rat MKK4 26398 P47809 Map2k4 mouse S78 447655 IERLRTHsIESsGKL X 9155 -Sgk1 SGK1 Q06226 rat SRF 501099 NP_001102772 Srf rat S73 451802 PTAGALYsGsEGDSE X -Sgk1 SGK1 Q06226 rat ROMK 24521 P35560 Kcnj1 rat S44 449605 RQRARLVsKEGRCNI IRK X -ERBB2 HER2 P04626 human PUMA 27113 Q9BXH1 BBC3 human Y172 29674705 PsPWRVLyNLIMGLL PUMA X X -ERBB2 HER2 P04626 human HER2 2064 P04626 ERBB2 human Y1222 448675 PAFDNLyyWDQDPPE X X 2243; 2249; 91415 -ERBB2 HER2 P04626 human DOCK7 85440 Q96N67 DOCK7 human Y1257 2756301 METVPQLyDFTETHN X X -ERBB2 HER2 P04626 human PUMA 27113 Q9BXH1 BBC3 human Y58 29674706 PTLLPAAyLCAPTAP PUMA X X -ERBB2 HER2 P04626 human HER2 2064 P04626 ERBB2 human Y1023 448682 DLVDAEEyLVPQQGF X -ERBB2 HER2 P04626 human PLXNB1 5364 O43157 PLXNB1 human Y1708 3413438 DSVGEPLyMLFRGIK Plexin_cytopl X -ERBB2 HER2 P04626 human PUMA 27113 Q9BXH1 BBC3 human Y152 29674707 ADDLNAQyERRRQEE PUMA X X -ERBB2 HER2 P04626 human PLXNB1 5364 O43157 PLXNB1 human Y1732 11485312 SVtGKAKyTLNDNRL Plexin_cytopl X -ERBB2 HER2 P04626 human HER2 2064 P04626 ERBB2 human Y877 448694 LDIDEtEyHADGGkV PK_Tyr_Ser-Thr X 2241 -ERBB2 HER2 P04626 human CTNNB1 1499 P35222 CTNNB1 human Y654 447585 RNEGVAtyAAAVLFR X -ERBB2 HER2 P04626 human HER2 2064 P04626 ERBB2 human Y1112 448674 DPsPLQRySEDPTVP X -ERBB2 HER2 P04626 human HER2 2064 P04626 ERBB2 human Y1221 449744 sPAFDNLyyWDQDPP X 2243; 2249; 91415 -ERBB2 HER2 P04626 human HER2 2064 P04626 ERBB2 human Y1248 447614 PtAENPEyLGLDVPV X X 2244; 2247 -ERBB2 HER2 P04626 human HER2 2064 P04626 ERBB2 human Y1139 448678 tCsPQPEyVNQPDVR X -ERBB2 HER2 P04626 human CDK1 983 P06493 CDK1 human Y15 447610 EkIGEGtyGVVykGR Pkinase X X 4539; 9111; 14566; 77897 -ERBB2 HER2 P04626 human LDH-A 3939 P00338 LDHA human Y10 454712 tLkDQLIyNLLkEEQ X X -ERBB2 HER2 P04626 human HER2 2064 P04626 ERBB2 human Y1196 448676 GAVENPEyLtPQGGA X 6942 -CDC42BPA MRCKA Q5VT25 human MRCKA 8476 Q5VT25 CDC42BPA human T403 12612503 HLPFVGFtYTSSCVL Pkinase_C X -CDC42BPA MRCKA Q5VT25 human MRCKA 8476 Q5VT25 CDC42BPA human S1003 801662701 RKKGCPGsTGFPPKR X -CDC42BPA MRCKA Q5VT25 human MRCKA 8476 Q5VT25 CDC42BPA human T240 12612501 QsSVAVGtPDYISPE Pkinase X -CDC42BPA MRCKA Q5VT25 human MRLC1 10398 P24844 MYL9 human S20 1863500 KRPQRAtsNVFAMFD X X 3674; 3671; 3675; 95777 -CDC42BPA MRCKA Q5VT25 human MRCKA 8476 Q5VT25 CDC42BPA human S234 12612500 MEDGTVQsSVAVGtP Pkinase X -OXSR1 OSR1 O95747 human NKCC2 6557 Q13621 SLC12A1 human T105 458228 LQtFGHNtMDAVPKI AA_permease_N X -OXSR1 OSR1 O95747 human NKCC1 6558 P55011 SLC12A2 human T207 467236 YYDtHTNtyYLRtFG AA_permease_N X X -OXSR1 OSR1 O95747 human NKCC2 6557 Q13621 SLC12A1 human T118 459122 KIEYYRNtGsISGPK AA_permease_N X -OXSR1 OSR1 O95747 human PAK1 29431 P35465 Pak1 rat T84 450680 LPSDFEHtIHVGFDA PBD X -OXSR1 OSR1 O95747 human Tau iso8 4137 P10636-8 MAPT human S324 449328 kVtskCGsLGNIHHk Tubulin-binding X -OXSR1 OSR1 O95747 human NCCT 6559 P55017 SLC12A3 human T60 469617 MRtFGYNtIDVVPtY AA_permease_N X -OXSR1 OSR1 O95747 human NCCT 6559 P55017 SLC12A3 human S73 469631 tYEHyANstQPGEPR AA_permease_N X -OXSR1 OSR1 O95747 human SMAD3 4088 P84022 SMAD3 human T179 451177 PQSNIPEtPPPGYLS X X -OXSR1 OSR1 O95747 human NKCC1 6558 P55011 SLC12A2 human T212 455545 TNtyYLRtFGHNtMD AA_permease_N X X -OXSR1 OSR1 O95747 human NKCC1 6558 P55011 SLC12A2 human T230 459123 RIDHyRHtAAQLGEk AA_permease_N X -OXSR1 OSR1 O95747 human NKCC1 6558 P55011 SLC12A2 human T203 467235 HQHYYYDtHTNtyYL AA_permease_N X X -OXSR1 OSR1 O95747 human NKCC2 6557 Q13621 SLC12A1 human S120 4708959 EYYRNtGsISGPKVN AA_permease_N X -OXSR1 OSR1 O95747 human NKCC2 6557 Q13621 SLC12A1 human T95 4708938 AYDsHTNtYYLQtFG AA_permease_N X X -OXSR1 OSR1 O95747 human Tau iso8 4137 P10636-8 MAPT human T30 1873559802 RKDQGGytMHQDQEG X -OXSR1 OSR1 O95747 human NKCC2 6557 Q13621 SLC12A1 human T100 458227 TNtYYLQtFGHNtMD AA_permease_N X X -OXSR1 OSR1 O95747 human NCCT 6559 P55017 SLC12A3 human T46 2286406 SSHPSHLtHSStFCM AA_permease_N X -OXSR1 OSR1 O95747 human NCCT 6559 P55017 SLC12A3 human T55 469616 SStFCMRtFGYNtID AA_permease_N X -OXSR1 OSR1 O95747 human SMAD2 4087 Q15796 SMAD2 human T220 448793 QSNYIPEtPPPGYIS X X -OXSR1 OSR1 O95747 human NKCC1 6558 P55011 SLC12A2 human T217 455546 LRtFGHNtMDAVPRI AA_permease_N X -SRC Src P12931 human MST1 58231 Q9JI11 Stk4 mouse Y433 463558 KIPQDGDyEFLKsWT Mst1_SARAH X X -SRC Src P12931 human TRIP6 22051 Q9Z1Y4 Trip6 mouse Y55 456050 PLPPEHCyQPPGVPE X X -SRC Src P12931 human PTEN 5728 P60484 PTEN human Y155 4000973 AQEALDFyGEVRTRD X -SRC Src P12931 human GJA1 2697 P17302 GJA1 human Y265 447815 kDCGsQkyAyFNGCs X X -SRC Src P12931 human SPTAN1 6709 Q13813 SPTAN1 human Y1073 449561 MkQVEELyHsLLELG X -SRC Src P12931 human YAP1 10413 P46937 YAP1 human Y407 473004 sGLsMsSySVPRtPD X -SRC Src P12931 human TIMP2 7077 P16035 TIMP2 human Y90 1257779601 EKDIEFIyTAPSSAV TIMP X X -SRC Src P12931 human APP iso2 11820 P12023-2 App mouse Y653 2061000 VMLkkkQyTsIHHGV APP_amyloid X -SRC Src P12931 human VEGFR3 2324 P35916 FLT4 human Y830 14312600 PLEEQCEyLSyDASQ X -SRC Src P12931 human Trap150 9967 Q9Y2W1 THRAP3 human Y344 480818 AAsGGAAytKRyLEE THRAP3_BCLAF1 X -SRC Src P12931 human CDCP1 64866 Q9H5V8 CDCP1 human Y734 451434 KDNDsHVyAVIEDTM X 9050 -SRC Src P12931 human HNF4 alpha 3172 P41235 HNF4A human Y288 22996303 IDDNEyAyLKAIIFF Hormone_recep X X -SRC Src P12931 human EYA3 2140 Q99504 EYA3 human S138 1870640411 SGLIQTPsPSQHSVL X -SRC Src P12931 human FAK 14083 P34152 Ptk2 mouse Y407 447888 IIDEEDtytMPSTRD X -SRC Src P12931 human Vinculin 396422 P12003 VCL chicken Y100 454004 QMLQADPySVPARDY Vinculin X -SRC Src P12931 human SHC1 iso3 6464 P29353-3 SHC1 human Y194 448509 EEPPDHQyyNDFPGK X -SRC Src P12931 human EYA3 2140 Q99504 EYA3 human Y426 1870640408 YRKVREIyDKHkSNV X -SRC Src P12931 human HDAC3 8841 O15379 HDAC3 human Y331 15228119 PySEyFEyFAPDFTL X X -SRC Src P12931 human KIF11 3832 P52732 KIF11 human Y211 463258 VHNkDEVyQILEkGA Kinesin X X -SRC Src P12931 human GBF1 8729 Q92538 GBF1 human Y516 5516141 VENPKMPyEMKEMAL Sec7_N X -SRC Src P12931 human ATG9A 79065 Q7Z3C6 ATG9A human Y8 62382600 MAQFDTEyQRLEAsy X X -SRC Src P12931 human GTF2I iso2 2969 P78347-2 GTF2I human Y248 448250 EESEDPDyyQyNIQG X -SRC Src P12931 human TRPV1 7442 Q8NER1 TRPV1 human Y200 458384 ASYtDSYyKGQTALH Ank_2 X -SRC Src P12931 human BCKDK 10295 O14874 BCKDK human Y246 1868515109 RRLCEHkyGNAPRVR X X -SRC Src P12931 human PLCG2 5336 P16885 PLCG2 human Y753 447940 ERDINSLyDVsRMyV X -SRC Src P12931 human CDH2 1000 P19022 CDH2 human Y884 450693 SSGGEQDyDyLNDWG CADH_Y-type_LIR X -SRC Src P12931 human BKR2 624 P30411 BDKRB2 human Y347 452100 RKKSWEVyQGVCQKG X -SRC Src P12931 human WNK4 65266 Q96J92 WNK4 human Y1164 40407605 KKEIEDLySRLGKQP X -SRC Src P12931 human GIT1 28964 Q9Y2X7 GIT1 human Y284 15702201 EELAMDVyDEVDRRE GIT_SHD X -SRC Src P12931 human GAB1 2549 Q13480 GAB1 human Y242 455030 FFQQQMIyDsPPSRA X X -SRC Src P12931 human AKAP8 10270 O43823 AKAP8 human Y53 40420004 TTGATySyGPASWEA X -SRC Src P12931 human ARHGAP3 1124 P52757 CHN2 human Y21 482808 VSSDAEEyQPPIWKS X X -SRC Src P12931 human hnRNP K 3190 P61978 HNRNPK human Y234 456002 PNFyDETyDyGGFTM X X -SRC Src P12931 human GluR2 29627 P19491 Gria2 rat Y869 476831 NsQNFATykEGyNVy X 3921 -SRC Src P12931 human ACLY 47 P53396 ACLY human Y682 450360 sRtTDGVyEGVAIGG Ligase_CoA X X -SRC Src P12931 human PSF 6421 P23246 SFPQ human Y691 473374 GPGtPAGyGrGrEEy X -SRC Src P12931 human DVL2 1856 O14641 DVL2 human Y18 12170303 VGEtKVIyHLDEEET DIX X -SRC Src P12931 human GTF2I 2969 P78347 GTF2I human Y248 448250 EESEDPDyyQYNIQA X -SRC Src P12931 human HLAA 3105 P04439 HLA-A human Y344 463579 sDRkGGsytQAAssD MHC_I_C X -SRC Src P12931 human PKCD 170538 P09215 Prkcd rat Y311 447573 TPETVGIyQGFEKKT X X 2055 -SRC Src P12931 human EPS8 2059 Q12929 EPS8 human Y485 450732 EHssVsEyHPADGyA X -SRC Src P12931 human DAPK1 1612 P53355 DAPK1 human Y490 487483 HCAAWHGyySVAKAL Ank_2 X X -SRC Src P12931 human RGS16 6004 O15492 RGS16 human Y177 448653 RFLkSPAyRDLAAQA RGS X -SRC Src P12931 human FAK 14083 P34152 Ptk2 mouse Y576 447889 RyMEDstyyKASKGK PK_Tyr_Ser-Thr X 3281 -SRC Src P12931 human ZC3H4 23211 Q9UPT8 ZC3H4 human Y247 477406 SRGRGRGyRGRGSRG X -SRC Src P12931 human PAG 55824 Q9NWQ8 PAG1 human Y317 450659 EEEIsAMyssVNKPG PAG X -SRC Src P12931 human DDR2 4921 Q16832 DDR2 human Y736 456861 FGMSRNLysGDyyRI PK_Tyr_Ser-Thr X -SRC Src P12931 human NR1H4 9971 Q96RI1 NR1H4 human Y77 1186568001 QISSSSYySNLGFYP X X -SRC Src P12931 human SF3B2 10992 Q13435 SF3B2 human Y379 474329 VtEEPEIyEPNFIFF X -SRC Src P12931 human BCLAF1 9774 Q9NYF8 BCLAF1 human Y80 3804248 YRGrGrGyyQGGGGr X -SRC Src P12931 human PDK1 5170 O15530 PDPK1 human Y376 447695 DEDCyGNyDNLLSQF X X -SRC Src P12931 human FHOD1 29109 Q9Y613 FHOD1 human Y99 31010701 REMLEGFyEEISKGR Formin_GBD_N X -SRC Src P12931 human SHC1 iso3 6464 P29353-3 SHC1 human Y272 448511 ELFDDPSyVNVQNLD X -SRC Src P12931 human UGT2B7 7364 P16662 UGT2B7 human Y438 7378201 RVINDPSyKENVMKL UDPGT X X -SRC Src P12931 human CD163L1 338056 P30205 CD163L1 cow Y1326 470034 DALAEAVyEELDYLL X -SRC Src P12931 human IRTKS 55971 Q9UHR4 BAIAP2L1 human Y156 462515 GsRNALkyEHKEIEy IMD X -SRC Src P12931 human DAG1 13138 Q62165 Dag1 mouse Y890 449630 PyRsPPPyVPP____ DAG1 X 32248 -SRC Src P12931 human EYA3 2140 Q99504 EYA3 human Y77 1869778703 QMySAKPyAHILSVP X X -SRC Src P12931 human GBF1 8729 Q92538 GBF1 human Y1374 1875829506 PsPLINQysLTVGLD X -SRC Src P12931 human GRK2 282682 P21146 GRK2 cow Y92 456873 FyEEIKKyEKLETEE RGS X -SRC Src P12931 human GLRB 2743 P48167 GLRB human Y435 3078004 RDFELSNyDCYGkPI Neur_chan_memb X -SRC Src P12931 human GluR6 2898 Q13002 GRIK2 human Y590 36320701 RFSPYEWyNPHPCNP Lig_chan X -SRC Src P12931 human NCAM-L1 3897 P32004 L1CAM human Y1176 456529 kDEtFGEyRSLEsDN Bravo_FIGEY X -SRC Src P12931 human HRas 3265 P01112 HRAS human Y64 5840738 DTAGQEEySAMRDQY Ras X -SRC Src P12931 human Src iso1 20779 P05480-1 Src mouse Y424 448234 RLIEDNEytARQGAK PK_Tyr_Ser-Thr X 2101; 6943; 59548; 70926; 78740; 94361; 17320 -SRC Src P12931 human NEDD4 iso4 4734 P46934-4 NEDD4 human Y332 3190648 RRGsLQAyTFEEQPT X X -SRC Src P12931 human SHP-1 5777 P29350 PTPN6 human Y564 448912 sKHkEDVyENLHTkN X 8849 -SRC Src P12931 human PARP1 142 P09874 PARP1 human Y992 1875398902 LYNEYIVyDIAQVNL PARP X X -SRC Src P12931 human PKCD 170538 P09215 Prkcd rat Y64 447581 STFDAHIyEGRVIQI X -SRC Src P12931 human FAK 5747 Q05397 PTK2 human Y925 447966 DRsNDkVyENVtGLV Focal_AT X X 3284 -SRC Src P12931 human CDC25A 993 P30304 CDC25A human Y59 57761916 LQGLGSDyEQPLEVK X X -SRC Src P12931 human ephexin-1 53972 Q8CHT1 Ngef mouse Y177 455579 IEQIGLLyQEyRDKS X -SRC Src P12931 human ANXA2 302 P07355 ANXA2 human Y24 449483 HstPPsAyGsVkAyt X -SRC Src P12931 human USP2 9099 O75604 USP2 human S207 803501400 ENYGRKGsASQVPSQ X -SRC Src P12931 human CD46 iso4 4179 P15529-4 CD46 human Y354 451709 kADGGAEyAtyQtkS X -SRC Src P12931 human iNOS 4843 P35228 NOS2 human Y1055 4115776 LPGKPKVyVQDILRQ NAD_binding_1 X -SRC Src P12931 human EFTU 281556 P49410 TUFM cow Y266 464399 LLPVESVySIPGRGT X -SRC Src P12931 human TLR3 7098 O15455 TLR3 human Y759 450187 EQFEYAAyIIHAYKD TIR X X -SRC Src P12931 human ITGB7 3695 P26010 ITGB7 human Y753 469601 YRLSVEIyDRREySR Integrin_b_cyt X -SRC Src P12931 human BCLAF1 9774 Q9NYF8 BCLAF1 human Y408 463073 DtEEtEDyRQFRksV THRAP3_BCLAF1 X -SRC Src P12931 human PTEN 5728 P60484 PTEN human Y174 464091 TIPSQRRyVyyysyL X -SRC Src P12931 human Calmodulin 24242 P0DP29 Calm3 rat Y100 448707 FDkDGNGyIsAAELR EF-hand_7 X -SRC Src P12931 human ROCK2 25537 Q62868 Rock2 rat Y722 464192 LADKNKIyESIEEAK X -SRC Src P12931 human MYH9 4627 P35579 MYH9 human Y158 463834 yAITDTAyRsMMQDr Myosin_head X -SRC Src P12931 human DAB1 13131 P97318 Dab1 mouse Y232 447961 SQKKEGVyDVPKSQP X X 3325 -SRC Src P12931 human EYA3 2140 Q99504 EYA3 human Y508 1870640410 IFPIENIySATKIGk X -SRC Src P12931 human PRKD2 25865 Q9BZL6 PRKD2 human Y87 178601700 kFPECGFyGLYDkIL X X -SRC Src P12931 human PELP1 27043 Q8IZL8 PELP1 human Y920 473548 EEEDEEEyFEEEEEE X -SRC Src P12931 human SRRT 51593 Q9BXP5 SRRT human Y92 7366809 DEHSSDPyHSGYEMP X -SRC Src P12931 human AGO2 27161 Q9UKV8 AGO2 human Y529 17533104 LPGKtPVyAEVkRVG Piwi X -SRC Src P12931 human FAM82A2 55177 Q96TC7 RMDN3 human Y176 19009800 DAESEGGytTANAEs X -SRC Src P12931 human ENG 2022 P17813 ENG human Y612 34729906 LLTAALWyIySHTRS X -SRC Src P12931 human EYA3 2140 Q99504 EYA3 human Y90 1870640403 VPVSETAyPGQTQyQ X X -SRC Src P12931 human GJA1 24392 P08050 Gja1 rat Y265 447815 kDCGsPkyAyFNGCS X X -SRC Src P12931 human CDH1 999 P12830 CDH1 human Y754 456025 DtRDNVyyyDEEGGG X -SRC Src P12931 human SPTAN1 6709 Q13813 SPTAN1 human Y1176 448817 AVQQQEVyGMMPRDE X -SRC Src P12931 human STAP2 55620 Q9UGK3 STAP2 human Y250 478353 PFLLDEDyEKVLGyV X -SRC Src P12931 human FCRL3 115352 Q96P31 FCRL3 human Y722 460222 EEDDEENyENVPRVL X -SRC Src P12931 human Ack 10188 Q07912 TNK2 human Y860 448884 KVsstHyyLLPERPs X -SRC Src P12931 human hnRNP K 3190 P61978 HNRNPK human Y230 456001 QPyDPNFyDETyDyG X X -SRC Src P12931 human CRIK 12704 P49025 Cit mouse Y1237 477284 TERSDLEyQLENIQV X -SRC Src P12931 human PIP5K1C 18717 O70161 Pip5k1c mouse Y644 450241 TDERSWVysPLHYSA X X -SRC Src P12931 human FCRL3 115352 Q96P31 FCRL3 human Y662 469981 PGDSNPIySQIWSIQ X -SRC Src P12931 human IRTKS 55971 Q9UHR4 BAIAP2L1 human Y439 462517 VVIPPPDyLECLsMG X -SRC Src P12931 human EYA3 2140 Q99504 EYA3 human Y208 1870640406 TILGQNQyQACYPSS X X -SRC Src P12931 human EGFR 1956 P00533 EGFR human Y764 465445 kEILDEAyVMAsVDN PK_Tyr_Ser-Thr X -SRC Src P12931 human PLSCR1 5359 O15162 PLSCR1 human Y69 2915403 PVPNQPVyNQPVyNQ X -SRC Src P12931 human PLK1 18817 Q07832 Plk1 mouse Y445 54066601 DSTRLILyNDGDSLQ POLO_box X -SRC Src P12931 human EYA3 2140 Q99504 EYA3 human S157 1870640413 GLTTSQPsPAHYSYP X -SRC Src P12931 human ZDHHC3 69035 Q8R173 Zdhhc3 mouse Y297 56580000 GKADPyQyVV_____ X -SRC Src P12931 human HLAB 3106 P01889 HLA-B human Y344 463580 SGGkGGsySQAACsD MHC_I_C X -SRC Src P12931 human FMIP 8563 Q13769 THOC5 human Y225 25802102 EIEVKKEyLSSLQPR FmiP_Thoc5 X -SRC Src P12931 human CDH2 1000 P19022 CDH2 human Y886 458306 GGEQDyDyLNDWGPR CADH_Y-type_LIR X -SRC Src P12931 human ANXA1 301 P04083 ANXA1 human Y21 447974 IENEEQEyVQtVkss X -SRC Src P12931 human BCLAF1 9774 Q9NYF8 BCLAF1 human Y81 4196063 RGrGrGyyQGGGGry X -SRC Src P12931 human PPP2CA 5515 P67775 PPP2CA human Y127 4251175 SRQITQVyGFYDECL Metallophos X -SRC Src P12931 human TLR2 24088 Q9QUN7 Tlr2 mouse Y647 1876860404 CYDAFVSySEQDSHW TIR X -SRC Src P12931 human CASP8 841 Q14790 CASP8 human Y380 460647 tDsEEQPyLEMDLSs Peptidase_C14 X X -SRC Src P12931 human ROMK 3758 P48048 KCNJ1 human Y337 451246 SKTKEGKyRVDFHNF IRK_C X X -SRC Src P12931 human NRas 4893 P01111 NRAS human Y32 15228782 QNHFVDEyDPTIEDs Ras X X -SRC Src P12931 human NCKIPSD 51517 Q9NZQ3 NCKIPSD human Y227 27528602 STSLDTLyTSSSPSE X -SRC Src P12931 human syntenin 6386 O00560 SDCBP human Y46 455029 IPHDGNLyPRLyPEL X -SRC Src P12931 human Cortactin 13043 Q60598 Cttn mouse Y421 447702 RPPssPIyEDAAPFK X X 4569 -SRC Src P12931 human FBX5 26271 Q9UKT4 FBXO5 human Y142 15339200 ALETSRLyEDsGYSs X X -SRC Src P12931 human HSP90B 3326 P08238 HSP90AB1 human Y301 462282 DDItQEEyGEFyksL HSP90 X X -SRC Src P12931 human WBP2 23558 Q969T9 WBP2 human Y231 464521 AEAAASAyyNPGNPH X -SRC Src P12931 human USP2 9099 O75604 USP2 human S225 803501401 SRVPEIIsPTYRPIG X -SRC Src P12931 human BKR2 624 P30411 BDKRB2 human Y177 457134 GVRWAKLysLVIWGC TM; 7tm_1 X -SRC Src P12931 human Cortactin 2017 Q14247 CTTN human Y470 447703 AyATEAVyESAEAPG X X -SRC Src P12931 human ARAF 369 P10398 ARAF human Y302 455522 GyRDsGyyWEVPPSE X -SRC Src P12931 human DAPK1 1612 P53355 DAPK1 human Y491 487484 CAAWHGyySVAKALC Ank_2 X X -SRC Src P12931 human GABRG2 14406 P22723 Gabrg2 mouse Y413 455818 ERDEEyGyECLDGKD Neur_chan_memb X -SRC Src P12931 human TRIP10 iso3 9322 Q15642-3 TRIP10 human Y471 480709 ESQDTPIyTEFDEDF X -SRC Src P12931 human EYA3 2140 Q99504 EYA3 human Y96 1869778704 AyPGQTQyQTLQQTQ X -SRC Src P12931 human GBF1 8729 Q92538 GBF1 human Y378 4736339 AsVHDMDyVNPRGVR X -SRC Src P12931 human Lmr1 iso2 11302 Q80YE4-2 Aatk mouse Y46 4269100 AQTGPDVyVLPLTEV X -SRC Src P12931 human KIF11 3832 P52732 KIF11 human Y231 14567513 AAtLMNAyssRSHSV Kinesin X X -SRC Src P12931 human BCLAF1 9774 Q9NYF8 BCLAF1 human Y150 7326502 SSRSSsPysksPVsK THRAP3_BCLAF1 X -SRC Src P12931 human RhoGDI alpha 396 P52565 ARHGDIA human Y27 459526 EDEHsVNykPPAQKs Rho_GDI X -SRC Src P12931 human YAP1 iso3 10413 P46937-3 YAP1 human Y341 15565111 PFLNSGTyHSRDEST X X -SRC Src P12931 human HSP90A 3320 P07900 HSP90AA1 human Y197 459268 LkEDQtEyLEErRIk HSP90 X -SRC Src P12931 human FHIT 2272 P49789 FHIT human Y114 447802 FHRNDsIyEELQKHD X X -SRC Src P12931 human ATG9A 79065 Q7Z3C6 ATG9A human Y15 15229023 yQRLEAsysDsPPGE X -SRC Src P12931 human CTNND1 12388 P30999 Ctnnd1 mouse Y228 449648 yPGGsDNyGsLsRVT X X 2911 -SRC Src P12931 human SIRT2 22933 Q8IXJ6 SIRT2 human Y104 479395 RSPStGLyDNLEKYH SIR2 X -SRC Src P12931 human LPIN1 23175 Q14693 LPIN1 human Y795 1871177712 FPNTEPFyAAFGNRP LNS2 X -SRC Src P12931 human SERT 6532 P31645 SLC6A4 human Y47 21697923 SGQISNGysAVPSPG 5HT_transport_N X -SRC Src P12931 human FCRL3 115352 Q96P31 FCRL3 human Y692 469982 HEELTVLySELKKTH X -SRC Src P12931 human Calmodulin 24242 P0DP29 Calm3 rat Y139 448708 DGDGQVNyEEFVQMM EF-hand_7 X -SRC Src P12931 human TrkB 25054 Q63604 Ntrk2 rat Y706 448812 DVyStDyyRVGGHTM PK_Tyr_Ser-Thr X 4621 -SRC Src P12931 human FXN 2395 Q16595 FXN human Y118 41196502 EDLADKPyTFEDYDV Frataxin_Cyay X -SRC Src P12931 human ARAP3 106952 Q8R5G7 Arap3 mouse Y1399 454957 DELEEPVyEEPVyEE X X -SRC Src P12931 human SHC1 6464 P29353 SHC1 human Y350 448510 EPPDHQyyNDFPGKE X X 2434 -SRC Src P12931 human G6PD 2539 P11413 G6PD human Y428 7705803 DLtyGNRyKNVkLPD G6PD_C X -SRC Src P12931 human PKCD 5580 Q05655 PRKCD human Y313 447573 ssEPVGIyQGFEKkT X 2055 -SRC Src P12931 human FAK 5747 Q05397 PTK2 human Y577 447890 yMEDstyyKAsKGKL PK_Tyr_Ser-Thr X 3281 -SRC Src P12931 human STAT5A 6776 P42229 STAT5A human Y694 447767 LAkAVDGyVkPQIkQ X X 9365; 9356; 9359; 9351; 4322; 9314; 3939; 40284; 5387; 14603; 66740; 51879; 72712 -SRC Src P12931 human BCLAF1 9774 Q9NYF8 BCLAF1 human Y93 3803712 GryHrGGyrPVWNRR X -SRC Src P12931 human profilin 1 5216 P07737 PFN1 human Y129 450514 GLINkkCyEMAsHLR Profilin X -SRC Src P12931 human SRRT 51593 Q9BXP5 SRRT human Y798 7366808 tPQGLMPyGQPRPPI ARS2 X -SRC Src P12931 human kindlin-2 10979 Q96AC1 FERMT2 human Y193 6153405 skTMTPtyDAHDGsP X -SRC Src P12931 human PKCD 5580 Q05655 PRKCD human Y334 450077 MQDNsGtyGkIWEGs X -SRC Src P12931 human TUBB3 10381 Q13509 TUBB3 human Y340 464858 IQskNssyFVEWIPN Tubulin_C X -SRC Src P12931 human FBP1 8880 Q96AE4 FUBP1 human Y268 7326500 FREVRNEyGsRIGGN X -SRC Src P12931 human CASP9 842 P55211 CASP9 human Y251 1147026600 LQFPGAVyGTDGCPV Peptidase_C14 X -SRC Src P12931 human PZR 9019 O95297 MPZL1 human Y263 449521 NksEsVVyADIRKN_ X 8088; 5543 -SRC Src P12931 human RBM10 iso2 8241 P98175-2 RBM10 human Y434 473480 SEEPPVDySYYQQDE X -SRC Src P12931 human hnRNP K 3190 P61978 HNRNPK human Y236 456003 FyDETyDyGGFTMMF X X -SRC Src P12931 human Trap150 9967 Q9Y2W1 THRAP3 human Y68 4929715 ErNHPrVyQNrDFrG X -SRC Src P12931 human CD93 22918 Q9NPY3 CD93 human Y644 463128 sRAMENQySPTPGTD X -SRC Src P12931 human ZC3H4 23211 Q9UPT8 ZC3H4 human Y1218 7366812 PTDRYNSyNRPRPKA X -SRC Src P12931 human PLCG1 25738 P10686 Plcg1 rat Y1253 448576 EGsFEARyQQPFEDF X -SRC Src P12931 human DOK1 1796 Q99704 DOK1 human Y362 448367 DPKEDPIyDEPEGLA X -SRC Src P12931 human PKCI 84006 F1M7Y5 Prkci rat Y265 450076 RVIGRGSyAKVLLVR Pkinase X X -SRC Src P12931 human MOR-1 18390 P42866 Oprm1 mouse Y336 5397200 SCLNPVLyAFLDENF 7tm_1 X -SRC Src P12931 human EPS8 2059 Q12929 EPS8 human Y774 457814 CPEGARVysQITVQk SAM_3 X -SRC Src P12931 human P70S6KB 6199 Q9UBS0 RPS6KB2 human Y45 465551 GLEPVGHyEEVELTE X X -SRC Src P12931 human AMPKA2 5563 P54646 PRKAA2 human Y179 11150878 tsCGsPNyAAPEVIS Pkinase X X -SRC Src P12931 human RAPGEF1 2889 Q13905 RAPGEF1 human Y504 448393 APIPSVPyAPFAAIL X -SRC Src P12931 human AP2B1 163 P63010 AP2B1 human Y737 450538 THRQGHIyMEMNFTN Alpha_adaptinC2 X X -SRC Src P12931 human PLK1 18817 Q07832 Plk1 mouse Y166 54066600 QIVLGCQyLHRNQVI Pkinase X -SRC Src P12931 human Villin 7429 P09327 VIL1 human Y256 454007 LKAALKLyHVsDsEG X -SRC Src P12931 human EYA3 2140 Q99504 EYA3 human S438 10941701 SNVGGLLsPQRKEAL X -SRC Src P12931 human WBP2 23558 Q969T9 WBP2 human Y192 20612405 MMDGAMGyVQPPPPP X -SRC Src P12931 human NEDD4 iso4 4734 P46934-4 NEDD4 human Y43 458526 ILGASDPyVRVTLYD C2 X X -SRC Src P12931 human CACNA1C 24239 P22002 Cacna1c rat Y2148 450658 PEDESCVyALGRGRS X X -SRC Src P12931 human LPIN1 23175 Q14693 LPIN1 human Y413 1871177711 DPEVAALyFPKNGDP X -SRC Src P12931 human PTPRJ 5795 Q12913 PTPRJ human Y1320 15228667 NtTAMtIyENLAPVT X X -SRC Src P12931 human p73 7161 O15350 TP73 human Y28 482867 SLEPDStyFDLPQSS X -SRC Src P12931 human FAK 5747 Q05397 PTK2 human Y1007 2867002 kMKLAQQyVMTSLQQ Focal_AT X -SRC Src P12931 human PTEN 5728 P60484 PTEN human Y46 3444123 AERLEGVyRNNIDDV X -SRC Src P12931 human HCN2 15166 O88703 Hcn2 mouse Y476 457528 FRQkIHDyYEHRYQG X -SRC Src P12931 human GSK3B 2932 P49841 GSK3B human Y216 448569 RGEPNVsyICsRyyR Pkinase X -SRC Src P12931 human lamin A/C 4000 P02545 LMNA human Y45 55369404 LNDrLAVyIDrVRsL Filament X X -SRC Src P12931 human DVL2 1856 O14641 DVL2 human Y275 12170305 VTLNMEKyNFLGISI PDZ X -SRC Src P12931 human ZAP70 7535 P43403 ZAP70 human Y319 447587 tsVyEsPysDPEELk X 2701; 2717; 14791; 73382; 82975; 31754 -SRC Src P12931 human APP iso2 11820 P12023-2 App mouse Y687 450343 NGyENPTykFFEQMQ APP_amyloid X -SRC Src P12931 human HK2 3099 P52789 HK2 human Y686 62906106 GTGSNACyMEEMRNV Hexokinase_2 X X -SRC Src P12931 human CDH1 999 P12830 CDH1 human Y797 6158370 tLMsVPRyLPRPANP X -SRC Src P12931 human EGFR 1956 P00533 EGFR human Y1092 448057 tFLPVPEyINQsVPk X 2236; 2234; 3777; 14565; 8543; 48576 -SRC Src P12931 human CACNA1C 775 Q13936 CACNA1C human Y2217 1043301 ELQDSRVyVSSL___ X -SRC Src P12931 human CTNNB1 12387 Q02248 Ctnnb1 mouse Y654 447585 RNEGVATyAAAVLFR X -SRC Src P12931 human TRPV4 63873 Q9EPK8 Trpv4 mouse Y110 4777176 PMDSLFDyGTYRHHP X -SRC Src P12931 human GRB2 14784 Q60631 Grb2 mouse Y160 452038 QMPQQPTyVQALFDF X -SRC Src P12931 human CTNND1 12388 P30999 Ctnnd1 mouse Y217 449647 PDGYGRHyEDGyPGG X -SRC Src P12931 human PTPRJ 5795 Q12913 PTPRJ human Y1311 473909 DSkVDLIyQNtTAMt X X -SRC Src P12931 human Ets-1 2113 P14921 ETS1 human Y283 449428 sLQRVPsyDsFDsED Ets1_N_flank X -SRC Src P12931 human ARAP3 106952 Q8R5G7 Arap3 mouse Y1404 454958 PVyEEPVyEEVGAFP X X -SRC Src P12931 human DGKA 1606 P23743 DGKA human Y335 486452 ILPPSSIyPSVLASG X X -SRC Src P12931 human Cortactin 2017 Q14247 CTTN human Y334 450862 VTQVssAyQktVPVE X -SRC Src P12931 human FLOT1 10211 O75955 FLOT1 human Y56 35494100 NVkSEkVyTRHGVPI Band_7 X -SRC Src P12931 human MDM2 4193 Q00987 MDM2 human Y281 4251185 EVyQVtVyQAGEsDt X -SRC Src P12931 human PRKD1 5587 Q15139 PRKD1 human Y502 449056 TTANVVYyVGENVVN PH X -SRC Src P12931 human GluR2 29627 P19491 Gria2 rat Y873 35547400 FATykEGyNVyGIEs X -SRC Src P12931 human UNC5C 22253 O08747 Unc5c mouse Y568 12563302 QGRVYEMyVTVHRKE ZU5 X -SRC Src P12931 human GAB1 2549 Q13480 GAB1 human Y373 447945 AsDtDssyCIPTAGM X X -SRC Src P12931 human ZC3H4 23211 Q9UPT8 ZC3H4 human Y158 3425765 GHRKyREysPPyAPs X -SRC Src P12931 human VEGFR3 2324 P35916 FLT4 human Y1063 473000 FGLARDIykDPDyVR PK_Tyr_Ser-Thr X X -SRC Src P12931 human SHC3 iso2 53358 Q92529-2 SHC3 human Y218 451254 GDGSDHPyyNSIPSK X -SRC Src P12931 human AKAP8 10270 O43823 AKAP8 human Y154 476956 RPsySyDyEFDLGSD X -SRC Src P12931 human SF3B2 10992 Q13435 SF3B2 human Y592 3457796 TIHGDLyyEGKEFET DUF382 X -SRC Src P12931 human NEDD4 iso4 4734 P46934-4 NEDD4 human Y647 36436801 RVAGMAVyHGKLLDG HECT X X -SRC Src P12931 human SHC1 6464 P29353 SHC1 human Y349 448509 EEPPDHQyyNDFPGK X X 2434 -SRC Src P12931 human ELMO1 9844 Q92556 ELMO1 human Y724 455566 PsNyDFVyDCN____ X -SRC Src P12931 human PPAR-gamma 19016 P37238 Pparg mouse Y78 36692605 SSISAPHyEDIPFTR PPARgamma_N X X -SRC Src P12931 human emerin 2010 P50402 EMD human Y74 451787 tRGDADMyDLPkkED X X -SRC Src P12931 human TGFBR2 7048 P37173 TGFBR2 human Y284 479864 KIFPYEEyASWKTEk PK_Tyr_Ser-Thr X -SRC Src P12931 human CDH2 1000 P19022 CDH2 human Y852 450692 NDPTAPPyDSLLVFD CADH_Y-type_LIR X -SRC Src P12931 human Villin 7429 P09327 VIL1 human Y60 454005 KTASSLSyDIHyWIG Gelsolin X -SRC Src P12931 human GRK2 156 P25098 GRK2 human Y86 447727 ARPLVEFyEEIKKyE RGS X -SRC Src P12931 human NOXA1 10811 Q86UR1 NOXA1 human Y110 17303900 RGHAAIDyTQLGLRF X X -SRC Src P12931 human p27Kip1 1027 P46527 CDKN1B human Y88 456818 kGsLPEFyyRPPRPP X X -SRC Src P12931 human CTNNB1 1499 P35222 CTNNB1 human Y86 447584 VADIDGQyAMTRAQR X -SRC Src P12931 human G6PD 2539 P11413 G6PD human Y249 462295 GTEGRGGyFDEFGII G6PD_C X X -SRC Src P12931 human NMDAR2A 2903 Q12879 GRIN2A human Y1267 461052 PATGEQVyQQDWAQN NMDAR2_C X -SRC Src P12931 human HIPK2 28996 Q9H2X6 HIPK2 human Y361 449571 SkAVCstyLQsRYyR Pkinase X -SRC Src P12931 human HDAC3 8841 O15379 HDAC3 human Y325 1267669100 AISEELPySEyFEyF X -SRC Src P12931 human plakophilin 3 11187 Q9Y446 PKP3 human Y195 451533 PGGLDDRysLVsEQL X X -SRC Src P12931 human RIPK1 8737 Q13546 RIPK1 human Y384 451864 kLQDEANyHLyGsRM X -SRC Src P12931 human AFAP 60312 Q8N556 AFAP1 human Y93 3891000 TSSLPEGyyEEAVPL X -SRC Src P12931 human SDHA 6389 P31040 SDHA human Y215 25682901 SLRYDTSyFVEYFAL FAD_binding_2 X X -SRC Src P12931 human TERT 7015 O14746 TERT human Y707 450084 QDPPPELyFVKVDVT X -SRC Src P12931 human DOK1 13448 P97465 Dok1 mouse Y146 455786 EMLENSLySPTWEGS X -SRC Src P12931 human TRPV6 114246 Q9R186 Trpv6 rat Y201 473577 YRPHNLIyyGEHPLS X -SRC Src P12931 human AKAP8 10270 O43823 AKAP8 human Y539 40420000 IVkMLEkyLKGEDPF AKAP95 X -SRC Src P12931 human SHC3 iso2 53358 Q92529-2 SHC3 human Y256 451255 FAGKEQTyyQGRHLG X -SRC Src P12931 human GIT1 28964 Q9Y2X7 GIT1 human Y321 15702200 FLPVNPEySATRNQG X -SRC Src P12931 human VEGFR3 2324 P35916 FLT4 human Y1333 2874408 ARGGQVFyNSEyGEL X -SRC Src P12931 human PTEN 5728 P60484 PTEN human Y240 448316 RREDKFMyFEFPQPL PTEN_C2 X X -SRC Src P12931 human iNOS 4843 P35228 NOS2 human Y151 457593 IEFVNQYyGSFKEAK NO_synthase X X -SRC Src P12931 human RSK2 6197 P51812 RPS6KA3 human Y483 464202 IItLkDVyDDGKyVY Pkinase X -SRC Src P12931 human EFTU 281556 P49410 TUFM cow Y357 55372823 QKVEAQVyILTKEEG GTP_EFTU_D3 X -SRC Src P12931 human smMLCK 4638 Q15746 MYLK human Y464 451414 QEGsIEVyEDAGsHy I-set X -SRC Src P12931 human PPP2CA 5515 P67775 PPP2CA human Y307 448571 VTRRtPDyFl_____ X X -SRC Src P12931 human RAF1 5894 P04049 RAF1 human Y341 447750 GQRDssyyWEIEASE X X -SRC Src P12931 human SNCA 6622 P37840 SNCA human Y125 448279 VDPDNEAyEMPsEEG Synuclein X -SRC Src P12931 human coronin 7 79585 P57737 CORO7 human Y758 2853108 GDTRVFLyELLPEsP X X -SRC Src P12931 human EYA3 2140 Q99504 EYA3 human Y108 1870640402 QTQPyAVyPQATQTy X X -SRC Src P12931 human FAK 5747 Q05397 PTK2 human Y898 485796 LSsPADSyNEGVKLQ X -SRC Src P12931 human PAK2 5062 Q13177 PAK2 human S141 448295 tVkQKyLsFtPPEkd X 2606 -SRC Src P12931 human JAM-A 50848 Q9Y624 F11R human Y280 458767 tSsKkVIysQPsARs X X -SRC Src P12931 human FHL1 iso1 2273 Q13642-1 FHL1 human Y149 15410160 FPkGEDFyCVTCHET LIM X -SRC Src P12931 human LPP 4026 Q93052 LPP human Y301 448949 GRyyEGyyAAGPGyG X -SRC Src P12931 human GBF1 8729 Q92538 GBF1 human Y877 1875829500 QDILEDMyHAIKNEE Sec7 X X -SRC Src P12931 human PPP2CA 5515 P67775 PPP2CA human Y284 457325 ELDDTLkySFLQFDP X -SRC Src P12931 human GRF-1 232906 Q91YM2 Arhgap35 mouse Y1105 448941 RNEEENIysVPHDST RhoGAP_pG1_pG2 X -SRC Src P12931 human Ack 10188 Q07912 TNK2 human Y859 448883 KKVsstHyyLLPERP X -SRC Src P12931 human Tks5 14218 O89032 Sh3pxd2a mouse Y619 3736027 ALEEETIyENEGFRP X -SRC Src P12931 human Gelsolin 2934 P06396 GSN human Y651 456962 ALGGkAAyRTsPRLK X -SRC Src P12931 human GBF1 8729 Q92538 GBF1 human Y1568 23109211 VRMQALTyLQRALLV X -SRC Src P12931 human PIP5K1C 23396 O60331 PIP5K1C human Y649 450241 TDERSWVysPLHYSA X X -SRC Src P12931 human NMDAR2A 2903 Q12879 GRIN2A human Y1387 455471 GRCPSDPyKHSLPSQ NMDAR2_C X -SRC Src P12931 human p27Kip1 1027 P46527 CDKN1B human Y74 475060 HkPLEGkyEWQEVEk CDI X X -SRC Src P12931 human DYN1 140694 P21575 Dnm1 rat Y597 447606 NTEQRNVykDYRQLE PH X -SRC Src P12931 human SRRT 51593 Q9BXP5 SRRT human Y836 7366807 YGAGrGNyDAFrGQG ARS2 X -SRC Src P12931 human syndecan-2 6383 P34741 SDC2 human Y179 448375 RKkDEGSyDLGErkP Syndecan X -SRC Src P12931 human DUSP12 11266 Q9UNI6 DUSP12 human Y179 1880475700 VDTSSAIyKQYRLQK X X -SRC Src P12931 human VEGFR3 2324 P35916 FLT4 human Y853 14312602 HLGRVLGyGAFGKVV PK_Tyr_Ser-Thr X -SRC Src P12931 human IGF2BP1 395953 O42254 IGF2BP1 chicken Y396 458348 SVSGAAPySSFMPPE X X -SRC Src P12931 human CD93 22918 Q9NPY3 CD93 human Y628 1031156 PQNAADsysWVPERA X -SRC Src P12931 human Cortactin 13043 Q60598 Cttn mouse Y482 447704 yQAEDDTyDGYESDL X X -SRC Src P12931 human Kv1.3 3738 P22001 KCNA3 human Y499 451294 EGEEQSQyMHVGsCQ X -SRC Src P12931 human GBF1 8729 Q92538 GBF1 human Y899 34551124 TGLVRENyVWNVLLH X -SRC Src P12931 human VCP 269523 Q01853 Vcp mouse Y805 449060 EDNDDDLyG______ X X -SRC Src P12931 human SH3PXD2B 285590 A1X283 SH3PXD2B human Y508 17303901 DMSASAGyEEIsDPD X -SRC Src P12931 human IQGAP1 8826 P46940 IQGAP1 human Y1510 450791 LVkLQQtyAALNskA RasGAP_C X X -SRC Src P12931 human WNK4 65266 Q96J92 WNK4 human Y1113 40407606 PSPVWMNySySSLCL X -SRC Src P12931 human CHKA 1119 P35790 CHKA human Y333 21041605 LMLIDFEySSYNYRG Choline_kinase X -SRC Src P12931 human GAB1 2549 Q13480 GAB1 human Y317 449581 PPtPGNtyQIPRTFP X X -SRC Src P12931 human DAAM1 23002 Q9Y4D1 DAAM1 human Y652 7791229 LERTFSAyQRQQDFF FH2 X X -SRC Src P12931 human KLF16 83855 Q9BXK1 KLF16 human Y10 22874704 AAVACVDyFAADVLM X -SRC Src P12931 human STAT3 6774 P40763 STAT3 human Y705 448192 DPGsAAPyLktKFIC X 4093; 9145; 4324; 9131; 9138; 4323; 4074; 4113; 48313; 20977; 25023; 8119; 52075; 52527; 73533; 61958; 73452; 16185; 74309 -SRC Src P12931 human CBL 867 P22681 CBL human Y774 448531 sENEDDGyDVPKPPV X 3555 -SRC Src P12931 human IKKB 3551 O14920 IKBKB human Y188 449632 sFVGTLQyLAPELLE Pkinase X -SRC Src P12931 human FAK 5747 Q05397 PTK2 human Y407 447888 IIDEEDtytMPSTRD X -SRC Src P12931 human p70S6K 83840 P67999 Rps6kb1 rat Y62 465552 DHGGVGPyELGMEHC X -SRC Src P12931 human MDM2 4193 Q00987 MDM2 human Y302 38546303 PEISLADyWKCtsCN zf-RanBP X -SRC Src P12931 human LRP1 4035 Q07954 LRP1 human Y4473 473712 VEIGNPTyKMYEGGE X X -SRC Src P12931 human occludin 100506658 Q16625 OCLN human Y398 5393504 KRtEQDHyEtDyttG X -SRC Src P12931 human ARHGEF2 9181 Q92974 ARHGEF2 human Y198 1869121005 IDEAEVIySELMSDF X -SRC Src P12931 human EGFR 1956 P00533 EGFR human Y1110 448058 GsVQNPVyHNQPLNP X 2220 -SRC Src P12931 human TLR3 364594 Q7TNI8 Tlr3 rat Y760 450187 EQFEYTAyIIHAQKD TIR X -SRC Src P12931 human ACLY 47 P53396 ACLY human Y252 462909 EAyPEEAyIADLDAk Citrate_bind X X -SRC Src P12931 human WWOX 51741 Q9NZC7 WWOX human Y33 449043 TTkDGWVyYANHTEE WW X X -SRC Src P12931 human NPHS1 4868 O60500 NPHS1 human Y1176 2299202 MAFPGHLyDEVERTY X -SRC Src P12931 human NMDAR1 2902 Q05586 GRIN1 human Y837 17613300 LIFIEIAyKRHKDAR CaM_bdg_C0 X -SRC Src P12931 human Gelsolin iso3 2934 P06396-3 GSN human Y438 23109545 GDSYIILyNYRHGGR Gelsolin X -SRC Src P12931 human VEGFR3 2324 P35916 FLT4 human Y1337 2874406 QVFyNSEyGELSEPS X X -SRC Src P12931 human CNK1 10256 Q969H4 CNKSR1 human Y665 33638001 KEQNRELySEGLGAW X -SRC Src P12931 human Ack 10188 Q07912 TNK2 human Y827 448882 SFASDPkyAtPQVIQ Inhibitor_Mig-6 X -SRC Src P12931 human RACK1 10399 P63244 RACK1 human Y246 451481 LCFSPNryWLCAATG WD40 X X -SRC Src P12931 human HNF4 alpha 3172 P41235 HNF4A human Y23 22996301 SAALDPAyTTLEFEN X X -SRC Src P12931 human PEAK1 79834 Q9H792 PEAK1 human Y635 449709 IVINPNAyDNLAIyK X -SRC Src P12931 human Kv2.1 25736 P15387 Kcnb1 rat Y814 22874700 FLRPNCVysSEGLTG X -SRC Src P12931 human DVL2 1856 O14641 DVL2 human Y295 12170306 ERGDGGIyIGSIMkG PDZ X -SRC Src P12931 human p53 7157 P04637 TP53 human Y220 34824801 rHsVVVPyEPPEVGS P53 X X -SRC Src P12931 human coronin 7 79585 P57737 CORO7 human Y288 2853109 GERQLYCyEVVPQQP X -SRC Src P12931 human CTNND2 18163 O35927 Ctnnd2 mouse Y1073 31014801 ERDRQRPySSSRtPs X -SRC Src P12931 human Villin 7429 P09327 VIL1 human Y64 3176603 SLSyDIHyWIGQDSS Gelsolin X -SRC Src P12931 human RHOU 58480 Q7L0Q8 RHOU human Y254 14918203 SkSWWKKyCCFV___ X -SRC Src P12931 human IRTKS 55971 Q9UHR4 BAIAP2L1 human Y163 462516 yEHKEIEyVEtVTSR IMD X -SRC Src P12931 human CDK4 1019 P11802 CDK4 human Y17 455500 AEIGVGAyGTVYkAR Pkinase X -SRC Src P12931 human CD133 8842 O43490 PROM1 human Y828 462569 RMDsEDVyDDVEtIP X X -SRC Src P12931 human CDCP1 64866 Q9H5V8 CDCP1 human Y762 455577 LQPEVDTyRPFQGTM X -SRC Src P12931 human ACLY 47 P53396 ACLY human Y1006 1868989001 PAtPLLDyALEVEkI Citrate_synt X X -SRC Src P12931 human VEGFR2 3791 P35968 KDR human Y1175 447901 AQQDGKDyIVLPISE X 2478; 3770 -SRC Src P12931 human SGEF 622434 D3YYY8 Arhgef26 mouse Y530 479144 TFDPYVKyCTNEVYQ RhoGEF X -SRC Src P12931 human EYA3 2140 Q99504 EYA3 human Y237 1870640400 TTLAATTyQSEKPSV X -SRC Src P12931 human AFAP 60312 Q8N556 AFAP1 human Y125 9691400 MSSSYESyDEEEEDG X -SRC Src P12931 human ARRB1 25387 P29066 Arrb1 rat Y54 458023 yLKERRVyVTLTCAF Arrestin_N X X -SRC Src P12931 human NCKIPSD 51517 Q9NZQ3 NCKIPSD human Y161 454233 LGADGGLyQIPLPSS X -SRC Src P12931 human Abl iso2 25 P00519-2 ABL1 human Y488 450295 EGCPEKVyELMRACW PK_Tyr_Ser-Thr X X -SRC Src P12931 human ataxin-2L 11273 Q8WWM7 ATXN2L human Y744 7366804 VPGQQGKyRGAKGSL X -SRC Src P12931 human RSK2 6197 P51812 RPS6KA3 human Y707 448775 KGAMAAtysALNRNQ X -SRC Src P12931 human occludin Q91049 OCLN chicken Y379 5393504 PELDESQyETDyTTA X -SRC Src P12931 human AKAP8 10270 O43823 AKAP8 human Y146 40420002 CLPEHNPyRPsySyD X -SRC Src P12931 human ARHGAP5 394 Q13017 ARHGAP5 human Y1109 455068 kGysDEIyVVPDDsQ RhoGAP_pG1_pG2 X -SRC Src P12931 human AKAP8 10270 O43823 AKAP8 human Y170 15417596 NGsFGGQySECRDPA X -SRC Src P12931 human girdin 55704 Q3V6T2 CCDC88A human Y1799 450762 QSkDsNPyAtLPRAS X X -SRC Src P12931 human STAP2 55620 Q9UGK3 STAP2 human Y22 11500606 GVLPSHYyESFLEKK PH X -SRC Src P12931 human CNK1 10256 Q969H4 CNKSR1 human Y519 50402001 PPREEDCySETEAED X -SRC Src P12931 human PDHA1 5160 P08559 PDHA1 human Y289 454752 MELQTYRyHGHsMsD E1_dh X -SRC Src P12931 human K19 3880 P08727 KRT19 human Y391 455049 LEGQEDHyNNLsAsk X X -SRC Src P12931 human occludin 100506658 Q16625 OCLN human Y402 458611 QDHyEtDyttGGEsC X -SRC Src P12931 human Kv2.1 3745 Q14721 KCNB1 human Y128 449085 YWGIDEIyLESCCQA BTB_2 X -SRC Src P12931 human 14-3-3 zeta 22631 P63101 Ywhaz mouse Y179 7316700 LNFSVFYyEILNSPE 14-3-3 X -SRC Src P12931 human FAK 5747 Q05397 PTK2 human Y742 6153381 HMVQTNHyQVSGYPG X -SRC Src P12931 human SOCS1 8651 O15524 SOCS1 human Y80 1868450203 LLDACGFyWGPLSVH SH2 X -SRC Src P12931 human RHOA 387 P61586 RHOA human Y34 473955 kDQFPEVyVPTVFEN Ras X -SRC Src P12931 human YAP1 iso3 10413 P46937-3 YAP1 human Y394 54390605 QQNRFPDyLEAIPGT X X -SRC Src P12931 human CYP19A1 1588 P11511 CYP19A1 human Y361 10433800 KVMENFIyESMRYQP p450 X X -SRC Src P12931 human PDK1 5170 O15530 PDPK1 human Y373 447694 sEDDEDCyGNyDNLL X X -SRC Src P12931 human Src 83805 Q9WUD9 Src rat Y419 448234 RLIEDNEyTARQGAk PK_Tyr_Ser-Thr X 2101; 6943; 59548; 70926; 78740; 94361; 17320 -SRC Src P12931 human Kv1.3 3738 P22001 KCNA3 human Y187 451293 FSEEIRFyQLGEEAM BTB_2 X -SRC Src P12931 human CELF2 iso3 29428 Q792H5-3 Celf2 rat Y39 1870336227 LKELFEPyGAVYQIN RRM_1 X X -SRC Src P12931 human Src 6714 P12931 SRC human Y93 4251105 VTTFVALyDyEsRTE SH3_1 X -SRC Src P12931 human PRKD1 5587 Q15139 PRKD1 human Y432 449055 KEGWMVHyTSKDTLR PH X -SRC Src P12931 human Tau iso8 4137 P10636-8 MAPT human Y18 454024 MEDHAGtyGLGDRKD X -SRC Src P12931 human PSD-95 1742 P78352 DLG4 human Y523 4093600 REDSVLSyETVTQME X X -SRC Src P12931 human AGO2 27161 Q9UKV8 AGO2 human Y393 17533102 AsFNtDPyVREFGIM ArgoL2 X X -SRC Src P12931 human GAB1 2549 Q13480 GAB1 human Y259 448877 AsVDssLyNLPRSys X X -SRC Src P12931 human emerin 2010 P50402 EMD human Y95 448938 kGyNDDyyEEsyFtT X X -SRC Src P12931 human GLO1 2739 Q04760 GLO1 human Y136 463450 GIAVPDVysACkRFE Glyoxalase X X -SRC Src P12931 human IRTKS 55971 Q9UHR4 BAIAP2L1 human Y37 21336505 LINLGKNyEkAVNAM IMD X -SRC Src P12931 human DDR2 4921 Q16832 DDR2 human Y740 456862 RNLysGDyyRIQGRA PK_Tyr_Ser-Thr X -SRC Src P12931 human HCRTR1 3061 O43613 HCRTR1 human Y358 2063600 SAANPIIyNFLSGKF 7tm_1; TM X -SRC Src P12931 human FCRL3 115352 Q96P31 FCRL3 human Y650 469980 PMELEPMySNVNPGD X -SRC Src P12931 human SLC25A4 291 P12235 SLC25A4 human Y195 457913 RAAyFGVyDtAkGML TM; Mito_carr X -SRC Src P12931 human IRTKS 55971 Q9UHR4 BAIAP2L1 human Y274 456190 SNVVRKDyDtLskCs X -SRC Src P12931 human TrkB 25054 Q63604 Ntrk2 rat Y705 448811 RDVyStDyyRVGGHT PK_Tyr_Ser-Thr X 4621 -SRC Src P12931 human CASP8 iso4 841 Q14790-4 CASP8 human Y397 460647 TDSEEQPyLEMDLSS Peptidase_C14 X -SRC Src P12931 human CSF2RB 12983 P26955 Csf2rb mouse Y595 450103 SFDFNGPyLGPPQSH X -SRC Src P12931 human PTEN 5728 P60484 PTEN human Y377 4695748 sDNEPDHyRYsDttD X -SRC Src P12931 human GAPDH 2597 P04406 GAPDH human Y42 450511 DPFIDLNyMVyMFQy Gp_dh_N X X -SRC Src P12931 human HRas 3265 P01112 HRAS human Y96 35524900 SFEDIHQyREQIKRV Ras X -SRC Src P12931 human Gelsolin 2934 P06396 GSN human Y465 456958 VPVDPATyGQFYGGD Gelsolin X -SRC Src P12931 human GRK2 156 P25098 GRK2 human Y13 456872 AVLADVSyLMAMEkS X -SRC Src P12931 human NMDAR2A 2903 Q12879 GRIN2A human Y1325 458211 RLLEGNFyGSLFSVP NMDAR2_C X X -SRC Src P12931 human STAT3 6774 P40763 STAT3 human Y68 904653401 LGEIDQQySRFLQES STAT_int X -SRC Src P12931 human CDCP1 64866 Q9H5V8 CDCP1 human Y743 455578 VIEDTMVyGHLLQDS X 14965 -SRC Src P12931 human SERT 6532 P31645 SLC6A4 human Y142 21697922 MELALGQyHRNGCIs SNF X -SRC Src P12931 human iNOS 18126 P29477 Nos2 mouse Y1049 4115776 LPGKPKVyVQDILQK NAD_binding_1 X -SRC Src P12931 human AR 11835 P19091 Ar mouse Y531 1243001 DHVLPIDyYFPPQKT X -SRC Src P12931 human EYA3 2140 Q99504 EYA3 human S225 1870640412 GVTGQTNsDAESTTL X -SRC Src P12931 human HDAC3 8841 O15379 HDAC3 human Y328 1267669101 EELPySEyFEyFAPD X X -SRC Src P12931 human TLR3 142980 Q99MB1 Tlr3 mouse Y760 450187 EQFEYTAyIIHAHkD TIR X -SRC Src P12931 human CDK1 396252 P13863 CDK1 chicken Y15 447610 EKIGEGtyGVVYKGR Pkinase X -SRC Src P12931 human caveolin-1 857 Q03135 CAV1 human Y14 448422 VDsEGHLytVPIREQ X X 3251 -SRC Src P12931 human CHKA 1119 P35790 CHKA human Y197 21041606 RSLGPkLyGIFPQGR Choline_kinase X -SRC Src P12931 human MUC1 4582 P15941 MUC1 human Y1229 448462 sstDRsPyEKVsAGN X -SRC Src P12931 human Alix 10015 Q8WUM4 PDCD6IP human Y319 457636 KkDNDFIyHDrVPDL BRO1 X -SRC Src P12931 human SHC1 6464 P29353 SHC1 human Y427 448511 ELFDDPsyVNVQNLD X 2431 -SRC Src P12931 human CCR7 1236 P32248 CCR7 human Y155 53340200 LCIsIDRyVAIVQAV 7tm_1 X -SRC Src P12931 human DAB1 13131 P97318 Dab1 mouse Y198 447629 EDVEDPVyQyIVFEA X X -SRC Src P12931 human KHSRP 8570 Q92945 KHSRP human Y583 7326501 WAAYYSHyYQQPPGP X -SRC Src P12931 human ITGB7 3695 P26010 ITGB7 human Y758 469602 EIyDRREySRFEkEQ Integrin_b_cyt X -SRC Src P12931 human PKHF1 72287 Q3TB82 Plekhf1 mouse Y208 1868624702 LRVCSLCyRELAAQK FYVE X -SRC Src P12931 human hnRNP K 3190 P61978 HNRNPK human Y458 465997 LQNsVkQySGkFF__ X -SRC Src P12931 human AurA 6790 O14965 AURKA human Y148 457653 kGkFGNVyLAREKQS Pkinase X -SRC Src P12931 human ICAM1 15894 P13597 Icam1 mouse Y518 450460 RQRKIRIyKLQkAQE X -SRC Src P12931 human STING 340061 Q86WV6 STING1 human Y245 1869808400 RVysNSIyELLENGQ TMEM173 X -SRC Src P12931 human TRAF4AF1 90417 Q9Y448 KNSTRN human Y87 3583497 TSVVKtVySLQPPSA X -SRC Src P12931 human Ezrin 7430 P15311 EZR human Y478 454875 PPPPPPVyEPVsyHV X X -SRC Src P12931 human GTF2I 2969 P78347 GTF2I human Y249 459606 ESEDPDyyQYNIQAG X -SRC Src P12931 human PRKD1 5587 Q15139 PRKD1 human Y95 764000 KFPECGFyGMYDKIL X -SRC Src P12931 human ZDHHC3 69035 Q8R173 Zdhhc3 mouse Y295 464577 DQGKADPyQyVV___ X -SRC Src P12931 human LPP 4026 Q93052 LPP human Y244 449712 APssGQIyGsGPQGy X -SRC Src P12931 human TIMP2 7077 P16035 TIMP2 human Y165 1257779600 RCPMIPCyISSPDEC TIMP X X -SRC Src P12931 human DAB1 13131 P97318 Dab1 mouse Y220 447630 PETEENIyQVPTSQK X X 3327 -SRC Src P12931 human SGK223 306506 D3ZMK9 Prag1 rat Y391 449701 AVQPEPIyAESAKRK X -SRC Src P12931 human endophilin B1 51100 Q9Y371 SH3GLB1 human Y80 465105 ARIEEFVyEkLDRKA BAR X X -SRC Src P12931 human AFAP 60312 Q8N556 AFAP1 human Y453 3891002 PEALHyDyIDVEMSA X -SRC Src P12931 human GRB10 2887 Q13322 GRB10 human Y67 448348 NASLESLySACSMQS X X -SRC Src P12931 human PKCI 84006 F1M7Y5 Prkci rat Y280 450075 LKKTDRIyAMKVVKK Pkinase X -SRC Src P12931 human TRIP6 7205 Q15654 TRIP6 human Y55 456050 PLPsEQCyQAPGGPE X X -SRC Src P12931 human EGFR 1956 P00533 EGFR human Y1016 448055 DVVDADEyLIPQQGF X X 2235 -SRC Src P12931 human FAK 14083 P34152 Ptk2 mouse Y577 447890 yMEDstyyKASKGKL PK_Tyr_Ser-Thr X 3281 -SRC Src P12931 human RACK1 10399 P63244 RACK1 human Y52 464119 LtrDEtNyGIPQRAL X -SRC Src P12931 human EPS8 2059 Q12929 EPS8 human Y525 457963 NRHIDRNyEPLKtQP X -SRC Src P12931 human CBL 12402 P22682 Cbl mouse Y737 448530 QQIDSCTyEAMYNIQ X -SRC Src P12931 human PANX1 24145 Q96RD7 PANX1 human Y199 462886 KYPIVEQyLkTkkNS Innexin X X -SRC Src P12931 human FLOT1 10211 O75955 FLOT1 human Y149 35494101 MGISVVSyTLkDIHD Band_7 X -SRC Src P12931 human G6PD 2539 P11413 G6PD human Y507 451668 GFQyEGtykWVNPHk G6PD_C X -SRC Src P12931 human NRF2 4780 Q16236 NFE2L2 human Y576 460703 RDEDGkPysPSEYSL X -SRC Src P12931 human EB1 22919 Q15691 MAPRE1 human Y247 59026901 QRIVDILyATDEGFV EB1 X X -SRC Src P12931 human Src 6714 P12931 SRC human Y530 448235 FTstEPQyQPGENL_ X 2105 -SRC Src P12931 human CDH5 1003 P33151 CDH5 human Y731 456049 PyDTLHIyGyEGSES CADH_Y-type_LIR X -SRC Src P12931 human ELMO1 9844 Q92556 ELMO1 human Y720 455565 IPKEPsNyDFVyDCN X -SRC Src P12931 human AKAP8 10270 O43823 AKAP8 human Y51 40420005 SVTTGATySyGPASW X -SRC Src P12931 human PKCI 84006 F1M7Y5 Prkci rat Y334 450074 RLFFVIEyVNGGDLM Pkinase X -SRC Src P12931 human PKCD 170538 P09215 Prkcd rat Y628 462681 KVKSPSDySNFDPEF Pkinase_C X -SRC Src P12931 human PLCG2 5336 P16885 PLCG2 human Y759 447941 LyDVsRMyVDPsEIN X 3874; 50535 -SRC Src P12931 human RSK2 6197 P51812 RPS6KA3 human Y529 464205 TITKTVEyLHAQGVV Pkinase X X -SRC Src P12931 human EFTU 281556 P49410 TUFM cow Y115 55372798 INAAHVEySTAARHY GTP_EFTU X -SRC Src P12931 human KRas 3845 P01116 KRAS human Y32 15228779 QNHFVDEyDPTIEDs Ras X X -SRC Src P12931 human MYD88 17874 P22366 Myd88 mouse Y58 1876167500 AEEMGFEyLEIRELE Death X -SRC Src P12931 human RACK1 10399 P63244 RACK1 human Y228 450543 LNEGkHLyTLDGGDI WD40 X X -SRC Src P12931 human syntenin 6386 O00560 SDCBP human Y4 23940700 ____MsLyPsLEDLk X -SRC Src P12931 human Cbl-c 23624 Q9ULV8 CBLC human Y341 14913506 SEEQLQLyWAMDSTF X -SRC Src P12931 human NPHS1 4868 O60500 NPHS1 human Y1193 469565 SGAWGPLyDEVQMGP X -SRC Src P12931 human Gelsolin 2934 P06396 GSN human Y409 456960 TDGLGLsyLSSHIAN X -SRC Src P12931 human PSF 6421 P23246 SFPQ human Y597 7366811 RRQREESySRMGyMD X -SRC Src P12931 human TFG 10342 Q92734 TFG human Y33 7366801 IHNEDITyDELVLMM PB1 X -SRC Src P12931 human EYA3 2140 Q99504 EYA3 human Y72 1870640405 NDyTSQMySAKPyAH X X -SRC Src P12931 human GJA1 2697 P17302 GJA1 human Y247 447814 VKGksDPyHAtsGAL X X -SRC Src P12931 human RSK2 6197 P51812 RPS6KA3 human Y580 3455194 GLLMtPCytANFVAP Pkinase X -SRC Src P12931 human Lmr1 iso2 11302 Q80YE4-2 Aatk mouse Y25 4269101 ENAEGDEyVADFSEQ X -SRC Src P12931 human CD133 8842 O43490 PROM1 human Y852 462570 GYHkDHVyGIHNPVM X X -SRC Src P12931 human GTF2I iso2 2969 P78347-2 GTF2I human Y611 448253 KPELVISyLPPGMAS X -SRC Src P12931 human RPT2 19179 P62192 Psmc1 mouse Y439 451910 EGtPEGLyL______ X -SRC Src P12931 human HER2 2064 P04626 ERBB2 human Y877 448694 LDIDEtEyHADGGkV PK_Tyr_Ser-Thr X X 2241 -SRC Src P12931 human DLC1 50768 Q9R0Z9 Dlc1 mouse Y702 1869008601 SAEDNVNyEGQSAYD RhoGAP X X -SRC Src P12931 human NCAM-L1 396059 Q90933 L1CAM chicken Y1186 456529 KDETFGEyRSLESEA Bravo_FIGEY X -SRC Src P12931 human FAK 5747 Q05397 PTK2 human Y397 447887 sVsEtDDyAEIIDEE X X 3283; 8556 -SRC Src P12931 human NMDAR2A 2903 Q12879 GRIN2A human Y1292 4109565 RISRQHsyDNIVDKP NMDAR2_C X -SRC Src P12931 human PAK3 5063 O75914 PAK3 human S154 448123 VNNQKYMsFTSGDKS X 2606 -SRC Src P12931 human CDH2 1000 P19022 CDH2 human Y820 458307 PIHAEPQyPVRsAAP X -SRC Src P12931 human EGFR 1956 P00533 EGFR human Y869 448061 LGAEEkEyHAEGGkV PK_Tyr_Ser-Thr X X 2231; 6963 -SRC Src P12931 human CTNND2 18163 O35927 Ctnnd2 mouse Y1112 473157 LKERKTDyEsAGNNA X -SRC Src P12931 human HK1 3098 P19367 HK1 human Y732 462391 YDrLVDEysLNAGkQ Hexokinase_2 X X -SRC Src P12931 human EGFR 1956 P00533 EGFR human Y727 457949 sGAFGtVykGLWIPE PK_Tyr_Ser-Thr X -SRC Src P12931 human hnRNP K 3190 P61978 HNRNPK human Y380 456004 yAGGrGsyGDLGGPI X X -SRC Src P12931 human Cortactin 2017 Q14247 CTTN human Y486 447704 yPAEDStyDEYENDL X -SRC Src P12931 human G6PD 2539 P11413 G6PD human Y322 4114824 EGEATkGyLDDPTVP G6PD_C X X -SRC Src P12931 human AGO2 27161 Q9UKV8 AGO2 human Y749 13830224 HPTEFDFyLCsHAGI Piwi X -SRC Src P12931 human Gelsolin 2934 P06396 GSN human Y603 456961 LKTPsAAyLWVGTGA Gelsolin X -SRC Src P12931 human FHL1 iso1 2273 Q13642-1 FHL1 human Y272 1015543 VFHQEQVyCPDCAkK LIM X -SRC Src P12931 human AFAP 60312 Q8N556 AFAP1 human Y94 3891001 SSLPEGyyEEAVPLs X -SRC Src P12931 human FAK 5747 Q05397 PTK2 human Y861 447965 PIGNQHIyQPVGKPD X X -SRC Src P12931 human CTNNB1 1499 P35222 CTNNB1 human Y333 471406 NIMRTytyEkLLWTT X X -SRC Src P12931 human Villin 7429 P09327 VIL1 human Y81 454006 EQGAAAIyTTQMDDF Gelsolin X -SRC Src P12931 human DYN1 140694 P21575 Dnm1 rat Y231 447605 LLPLRRGyIGVVNRS Dynamin_M X -SRC Src P12931 human GIT1 28964 Q9Y2X7 GIT1 human Y246 12243296 PDHKNGHyIIPQMAD X -SRC Src P12931 human FLOT2 83764 Q9Z2S9 Flot2 rat Y163 475941 DVyDKVDyLSSLGKT Band_7 X -SRC Src P12931 human PRC1 9055 O43663 PRC1 human Y464 474466 QTETEMLyGsAPRtP MAP65_ASE1 X -SRC Src P12931 human Fos 2353 P01100 FOS human Y30 473044 AGDSLSYyHsPADSF X X -SRC Src P12931 human eNOS 287024 P29473 NOS3 cow Y83 456466 WELGSITyDTLCAQS X X -SRC Src P12931 human Trap150 9967 Q9Y2W1 THRAP3 human Y107 7366806 NrGGYGNyrSNWQNy X -SRC Src P12931 human EFTU 281556 P49410 TUFM cow Y246 474427 LLDAVDTyIPVPTRD GTP_EFTU X -SRC Src P12931 human HCN4 10021 Q9Y3Q4 HCN4 human Y531 1240811 RRQYQEKyKQVEQYM X -SRC Src P12931 human PLD2 5338 O14939 PLD2 human Y511 10036100 FFWLGKDySNLITKD X -SRC Src P12931 human CLCN3 iso2 84360 P51792-2 Clcn3 rat Y284 3577859 FSLEEVSyYFPLKTL Voltage_CLC X -SRC Src P12931 human ATP4A 397552 P19156 ATP4A pig Y7 484289 _MGKAENyELyQVEL H-K_ATPase_N X -SRC Src P12931 human RRas 6237 P10301 RRAS human Y66 448122 DPTIEDSyTKICSVD Ras X -SRC Src P12931 human SLC11A1 6556 P49279 SLC11A1 human Y15 4706965 QRLSGSSyGSISSPT X -SRC Src P12931 human syndecan-4 6385 P31431 SDC4 human Y180 474327 KkKDEGsyDLGKKPI Syndecan X X -SRC Src P12931 human PLCG1 25738 P10686 Plcg1 rat Y783 447667 EGRNPGFyVEANPMP X 2821; 14461; 14008; 25678; 88717 -SRC Src P12931 human PKCD 170538 P09215 Prkcd rat Y332 450077 IPDNNGTyGKIWEGS X -SRC Src P12931 human IRTKS 55971 Q9UHR4 BAIAP2L1 human Y293 472861 PAPSGRAytsPLIDM X -SRC Src P12931 human tensin 3 64759 Q68CZ2 TNS3 human Y1206 9824601 sHsFRGAyGLAMKVA SH2 X X -SRC Src P12931 human YAP1 iso3 10413 P46937-3 YAP1 human Y357 473004 SGLSMSSySVPRtPD X X -SRC Src P12931 human RSK2 6197 P51812 RPS6KA3 human Y470 478835 EIEILLRyGQHPNII Pkinase X -SRC Src P12931 human NDFIP2 54602 Q9NV92 NDFIP2 human Y167 3973278 TTSDTEVyGEFyPVP X -SRC Src P12931 human STAP2 55620 Q9UGK3 STAP2 human Y322 3974222 GDGPAVDyENQDVAS X -SRC Src P12931 human SORBS1 iso5 20411 Q62417-5 Sorbs1 mouse Y326 460519 RAEPKSIyEYQPGKS X -SRC Src P12931 human TFG 10342 Q92734 TFG human Y247 7366802 EGQMYQQyQQQAGYG X -SRC Src P12931 human AKAP8 10270 O43823 AKAP8 human Y152 7366805 PyRPsySyDyEFDLG X X -SRC Src P12931 human SHC1 iso3 6464 P29353-3 SHC1 human Y195 448510 EPPDHQyyNDFPGKE X -SRC Src P12931 human FAK 5747 Q05397 PTK2 human Y441 462051 GDVHQGIyMsPENPA PK_Tyr_Ser-Thr X -SRC Src P12931 human RBM10 iso2 8241 P98175-2 RBM10 human Y905 7326503 LGArGSsyGVTSTES X -SRC Src P12931 human caveolin-2 858 P51636 CAV2 human Y19 450198 LFMDDDsysHHsGLE Caveolin X -SRC Src P12931 human DLC1 50768 Q9R0Z9 Dlc1 mouse Y452 1869008602 NVPGSILySSSGELA X X -SRC Src P12931 human GUCY1B1 2983 Q02153 GUCY1B1 human Y192 469612 ESKEEDFyEDLDRFE X X -SRC Src P12931 human syndecan-4 6385 P31431 SDC4 human Y197 454904 kAPtNEFyA______ X -SRC Src P12931 human CDC42 iso1 998 P60953-1 CDC42 human Y64 450272 DTAGQEDyDRLRPLS Ras X X -SRC Src P12931 human endophilin A2 6455 Q99961 SH3GL1 human Y315 450745 QPSCKALyDFEPEND SH3_1 X X -SRC Src P12931 human RhoGDI beta 397 P52566 ARHGDIB human Y24 448978 ELdskLNykPPPQks Rho_GDI X X -SRC Src P12931 human PANX1 24145 Q96RD7 PANX1 human Y309 54421200 KTDVLkVyEILPTFD X X -SRC Src P12931 human EYA3 2140 Q99504 EYA3 human Y325 1870640414 HSLLTGSyAQKYGKD X -SRC Src P12931 human NELFCD iso4 51497 Q8IXH7-4 NELFCD human Y6 23003806 __MDEDYyGSAAEWG TH1 X X -SRC Src P12931 human calponin 3 1266 Q15417 CNN3 human Y10 6154088 HFNkGPsyGLsAEVK X -SRC Src P12931 human CDH5 1003 P33151 CDH5 human Y685 455658 LDARPsLyAQVQKPP X X -SRC Src P12931 human EWS 2130 Q01844 EWSR1 human Y278 463305 HPSSMGVyGQESGGF X -SRC Src P12931 human AKAP8 10270 O43823 AKAP8 human Y150 15407467 HNPyRPsySyDyEFD X -SRC Src P12931 human EYA3 2140 Q99504 EYA3 human Y67 1870640404 IPRSSNDyTSQMySA X -SRC Src P12931 human NMDAR2A 2903 Q12879 GRIN2A human Y1184 476852 GLsNNDQyKLySKHF NMDAR2_C X -SRC Src P12931 human EPS8 2059 Q12929 EPS8 human Y602 450736 LGRADPPytHtIQKQ X -SRC Src P12931 human Gelsolin 2934 P06396 GSN human Y86 456959 VPVPTNLyGDFFTGD Gelsolin X -SRC Src P12931 human TACE 57027 Q9Z1K9 Adam17 rat Y702 28706300 DKKLDKQyESLSLFH X -SRC Src P12931 human P130Cas 9564 P56945 BCAR1 human Y128 448778 SKAQQGLyQVPGPsP X -SRC Src P12931 human p27Kip1 1027 P46527 CDKN1B human Y89 456819 GsLPEFyyRPPRPPK X X -SRC Src P12931 human EGFR 1956 P00533 EGFR human Y944 463349 PICtIDVyMIMVKCW PK_Tyr_Ser-Thr X X -SRC Src P12931 human G6PD 2539 P11413 G6PD human Y112 455132 NsyVAGQyDDAASYQ G6PD_N X X -SRC Src P12931 human TIMP2 7077 P16035 TIMP2 human Y62 23152807 VDsGNDIyGNPIkRI TIMP X X -SRC Src P12931 human NMDAR2A 2903 Q12879 GRIN2A human Y1423 476854 SRGHNDVyISEHVMP NMDAR2_C X -SRC Src P12931 human EGFR 1956 P00533 EGFR human Y1125 449795 APsRDPHyQDPHstA X -SRC Src P12931 human PBK 55872 Q96KB5 PBK human Y74 473837 NPICNDHyRsVyQkR Pkinase X X -SRC Src P12931 human RhoGDI beta 397 P52566 ARHGDIB human Y153 7386101 yGPRPEEyEFLtPVE Rho_GDI X X -SRC Src P12931 human DVL2 1856 O14641 DVL2 human Y463 12170307 SDVVDWLyHHVEGFP DEP X -SRC Src P12931 human DYN2 1785 P50570 DNM2 human Y597 451200 NtEQRNVykDLRQIE PH X -SRC Src P12931 human SHP-1 5777 P29350 PTPN6 human Y536 448506 QkGQEsEyGNItyPP X X -SRC Src P12931 human ITGB3 3690 P05106 ITGB3 human Y773 448012 DtANNPLyKEAtstF Integrin_b_cyt X -SRC Src P12931 human PLEKHG2 64857 Q9H7P9 PLEKHG2 human Y489 23133014 sEPVKDPyVMFPQNA X -SRC Src P12931 human DMAP1 55929 Q9NPF5 DMAP1 human Y246 998916 EQVAEEEyLLQELRK DMAP1 X X -SRC Src P12931 human TRIM25 7706 Q14258 TRIM25 human Y278 450585 NSkFDtIyQILLkkk X -SRC Src P12931 human SYNJ2 8871 O15056 SYNJ2 human Y490 27166601 LLLVGDVyGEEVADK X -SRC Src P12931 human SYN1 281510 P17599 SYN1 cow Y301 478277 VVALTKTyATTEPFI Synapsin_C X -SRC Src P12931 human CEACAM1 634 P13688 CEACAM1 human Y520 451429 LTATEIIysEVKKQ_ X X -SRC Src P12931 human STAT5B 6777 P51692 STAT5B human Y699 448198 tAkAVDGyVkPQIkQ X 9365; 9356; 9359; 9351; 4322; 9314; 3939; 40284; 5387; 14603; 66740; 51879; 72712 -SRC Src P12931 human RBM10 iso2 8241 P98175-2 RBM10 human Y16 7366800 RGDRTGRyGATDRSQ X -SRC Src P12931 human RAC1 5879 P63000 RAC1 human Y64 475227 DTAGQEDyDRLRPLs Ras X -SRC Src P12931 human RGS16 6004 O15492 RGS16 human Y168 448652 TLMEKDSyPRFLkSP RGS X X -SRC Src P12931 human GRK2 156 P25098 GRK2 human Y92 456873 FyEEIKKyEkLETEE RGS X -SRC Src P12931 human RAF1 5894 P04049 RAF1 human Y340 447749 RGQRDssyyWEIEAS X -SRC Src P12931 human PTEN 5728 P60484 PTEN human Y315 448317 RADNDKEyLVLtLtK PTEN_C2 X -SRC Src P12931 human VAMP7 6845 P51809 VAMP7 human Y45 27806317 SENNKLTySHGNYLF Longin X X -SRC Src P12931 human FAK 5747 Q05397 PTK2 human Y194 18122800 ALEKKSNyEVLEkDV FERM_M X -SRC Src P12931 human MEGF10 84466 Q96KG7 MEGF10 human Y1030 12186245 LSSSENPyATIKDPP X -SRC Src P12931 human CDH5 1003 P33151 CDH5 human Y658 456048 GEMDTTSyDVSVLNs X -SRC Src P12931 human CTNNB1 1499 P35222 CTNNB1 human Y654 447585 RNEGVAtyAAAVLFR X -SRC Src P12931 human Daple 440193 Q9P219 CCDC88C human Y2025 899136400 PQTVWyEyGCV____ X X -SRC Src P12931 human EYA3 2140 Q99504 EYA3 human Y105 1870640401 TLQQTQPyAVyPQAT X X -SRC Src P12931 human ADAM12 11489 Q61824 Adam12 mouse Y901 448371 PRPSHNAyIK_____ X X -SRC Src P12931 human NDUFV2 4729 P19404 NDUFV2 human Y193 25682900 VQINDNYyEDLTAKD 2Fe-2S_thioredx X X -SRC Src P12931 human RhoGDI alpha 396 P52565 ARHGDIA human Y156 469606 YGPRAEEyEFLtPVE Rho_GDI X X -SRC Src P12931 human AKAP8 10270 O43823 AKAP8 human Y80 40420001 PAMHMASyGPEPCTD X -SRC Src P12931 human TRPV4 63873 Q9EPK8 Trpv4 mouse Y805 6097708 DPGKSEIyQYYGFSH X -SRC Src P12931 human CTNND2 18163 O35927 Ctnnd2 mouse Y1176 461085 QEPSRkDyETyQPFP X -SRC Src P12931 human Daple 440193 Q9P219 CCDC88C human Y2023 899136401 GDPQTVWyEyGCV__ X X -SRC Src P12931 human PLSCR1 5359 O15162 PLSCR1 human Y74 464050 PVyNQPVyNQPVGAA X -SRC Src P12931 human CDH2 1000 P19022 CDH2 human Y860 458305 DSLLVFDyEGSGSTA CADH_Y-type_LIR X -SRC Src P12931 human KHSRP 8570 Q92945 KHSRP human Y317 3556400 GFGDrNEyGsRIGGG X -SRC Src P12931 human EFTU 281556 P49410 TUFM cow Y92 38482677 GGAKFKKyEEIDNAP GTP_EFTU X -SRC Src P12931 human Vinculin 396422 P12003 VCL chicken Y1134 454003 WVRKTPWyQ______ X X -SRC Src P12931 human KRas 3845 P01116 KRAS human Y64 5840743 DTAGQEEySAMRDQY Ras X X -SRC Src P12931 human nAChRA7 1139 P36544 CHRNA7 human Y386 457466 ASNGNLLyIGFRGLD Neur_chan_memb X -SRC Src P12931 human ER-alpha 2099 P03372 ESR1 human Y537 448103 CKNVVPLyDLLLEML X -SRC Src P12931 human syndecan-1 6382 P18827 SDC1 human Y286 458494 KkkDEGsysLEEPkQ Syndecan X -SRC Src P12931 human VAV3 10451 Q9UKW4 VAV3 human Y173 455605 EDEGGEVyEDLMKAE X -SRC Src P12931 human RHOA 387 P61586 RHOA human Y66 475231 DtAGQEDyDRLRPLS Ras X -SRC Src P12931 human Ret 5979 P07949 RET human Y905 447627 DVyEEDsyVKRsQGR PK_Tyr_Ser-Thr X 3221 -SRC Src P12931 human PKHF1 72287 Q3TB82 Plekhf1 mouse Y268 1868624701 WPTQVEFyASGVSWS X -SRC Src P12931 human GRF-1 2909 Q9NRY4 ARHGAP35 human Y1087 449570 DGFDPsDyAEPMDAV RhoGAP_pG1_pG2 X -SRC Src P12931 human Trap150 9967 Q9Y2W1 THRAP3 human Y118 6422800 WQNyrQAysPRRGRS X -SRC Src P12931 human TRPV6 114246 Q9R186 Trpv6 rat Y202 473578 RPHNLIyyGEHPLSF X -SRC Src P12931 human GBF1 8729 Q92538 GBF1 human Y317 1875829502 EQPGsPGySTATEPG X -SRC Src P12931 human Cofilin-1 1072 P23528 CFL1 human Y68 449642 GQtVDDPyAtFVkML Cofilin_ADF X X -SRC Src P12931 human AFAP 60312 Q8N556 AFAP1 human Y451 475079 TDPEALHyDyIDVEM X -SRC Src P12931 human Cortactin 13043 Q60598 Cttn mouse Y466 447703 TyTSEPVyETTEAPG X X -SRC Src P12931 human Fos 2353 P01100 FOS human Y10 473043 FSGFNADyEASSSRC X X -SRC Src P12931 human RSK2 6197 P51812 RPS6KA3 human Y644 473285 KFSLSGGyWNSVSDT Pkinase X -SRC Src P12931 human CRIK 12704 P49025 Cit mouse Y1246 57761910 LENIQVLySHEKVKM X -SRC Src P12931 human GJA1 2697 P17302 GJA1 human Y313 454254 sEQNWANysAEQNRM Connexin43 X X -SRC Src P12931 human nAChRA7 1139 P36544 CHRNA7 human Y442 457467 KILEEVRyIANRFRC Neur_chan_memb X -SRC Src P12931 human TAZ 97064 Q9EPK5 Wwtr1 mouse Y316 27138200 sGLGLGCySVPTTPE X -SRC Src P12931 human ATP1A1 476 P05023 ATP1A1 human Y149 54363508 ITGCFSYyQEAKSSk TM X -SRC Src P12931 human PBK 55872 Q96KB5 PBK human Y272 54400800 DFDDEAYyAALGTRP Pkinase X -SRC Src P12931 human ATP1A1 476 P05023 ATP1A1 human Y260 454981 tARGIVVytGDrtVM E1-E2_ATPase X X -SRC Src P12931 human tensin 3 64759 Q68CZ2 TNS3 human Y1173 9824600 QDTSkFWykADISRE SH2 X X -SRC Src P12931 human PKCD 170538 P09215 Prkcd rat Y565 447576 IRVDTPHyPRWITKE Pkinase X -SRC Src P12931 human VEGFR3 2324 P35916 FLT4 human Y833 14312601 EQCEyLSyDASQWEF X -SRC Src P12931 human hnRNP K 3190 P61978 HNRNPK human Y225 456000 IkGRAQPyDPNFyDE X X -SRC Src P12931 human ENG 2022 P17813 ENG human Y614 34729907 TAALWyIySHTRSPS X -SRC Src P12931 human GABRG2 14406 P22723 Gabrg2 mouse Y411 455817 LQERDEEyGyECLDG Neur_chan_memb X -SRC Src P12931 human LPIN1 23175 Q14693 LPIN1 human Y398 1871177710 HLGADGVyLDDLTDM X -SRC Src P12931 human PTTG1IP 754 P53801 PTTG1IP human Y174 454097 LFkEENPyARFENN_ X -SRC Src P12931 human FAK 14083 P34152 Ptk2 mouse Y925 447966 DRSNDKVyENVTGLV Focal_AT X X 3284 -SRC Src P12931 human CAPN2 824 P17655 CAPN2 human Y625 3413522 RSGtMNSyEMRkALE X -SRC Src P12931 human EGFR 1956 P00533 EGFR human Y915 384460500 MTFGSkPyDGIPASE PK_Tyr_Ser-Thr X X -SRC Src P12931 human DDR2 4921 Q16832 DDR2 human Y471 451276 EQGsNstyDrIFPLR X -SRC Src P12931 human NEDD4 iso4 4734 P46934-4 NEDD4 human Y585 4155214 DGEKGLDyGGVAREW X X -SRC Src P12931 human SPRY2 10253 O43597 SPRY2 human Y55 448849 AIRNTNEytEGPTVV X X -SRC Src P12931 human Pyk2 19229 Q9QVP9 Ptk2b mouse Y402 447955 CSIESDIyAEIPDET X 3291 -SRC Src P12931 human Kv2.1 25736 P15387 Kcnb1 rat Y690 22874701 LLPSLGLyHDPLRNR X -SRC Src P12931 human ARHGEF7 iso1 8874 Q14155-1 ARHGEF7 human Y442 3753309 PAPLTPAyHTLPHPS X -SRC Src P12931 human PZR 9019 O95297 MPZL1 human Y241 451272 sHQGPVIyAQLDHsG X 8131 -SRC Src P12931 human Pyk2 2185 Q14289 PTK2B human Y402 447955 CsIEsDIyAEIPDEt X X 3291 -SRC Src P12931 human DVL2 1856 O14641 DVL2 human Y27 12170304 LDEEETPyLVkIPVP DIX X -SRC Src P12931 human PTPRA iso6 5786 P18433-2 PTPRA human Y789 447613 yIDAFSDyANFK___ X 4481 -SRC Src P12931 human FAK 25614 O35346 Ptk2 rat Y397 447887 SVSETDDyAEIIDEE X 3283; 8556 -SRC Src P12931 human AR 367 P10275 AR human Y535 470068 MDSYSGPyGDMRLET X -SRC Src P12931 human AT1 185 P30556 AGTR1 human Y319 448745 YFLQLLKyIPPKAKS X -SRC Src P12931 human GAK 2580 O14976 GAK human Y1149 23108884 CTQPRPNyAsNFsVI X X -SRC Src P12931 human HER2 2064 P04626 ERBB2 human Y1248 447614 PtAENPEyLGLDVPV X 2244; 2247 -SRC Src P12931 human RHOA 11848 Q9QUI0 Rhoa mouse Y42 150180312 VPTVFENyVADIEVD Ras X -SRC Src P12931 human TfR 7037 P02786 TFRC human Y20 448928 FGGEPLsytRFsLAR X -SRC Src P12931 human Kv2.1 25736 P15387 Kcnb1 rat Y128 449085 YWGIDEIyLESCCQA BTB_2 X -SRC Src P12931 human BCLAF1 9774 Q9NYF8 BCLAF1 human Y284 476579 VGNGssRysPsQNsP THRAP3_BCLAF1 X -SRC Src P12931 human GluR2 29627 P19491 Gria2 rat Y876 452173 ykEGyNVyGIEsVkI X 4027; 3921 -SRC Src P12931 human PTEN 5728 P60484 PTEN human Y68 7331394 HKNHYkIyNLCAERH X -SRC Src P12931 human WAVE1 8936 Q92558 WASF1 human Y125 457673 PIPLQETyDVCEQPP X X -SRC Src P12931 human LPP 4026 Q93052 LPP human Y300 448948 QGRyyEGyyAAGPGy X -SRC Src P12931 human ACLY 47 P53396 ACLY human Y227 1868989000 KVDATADyICkVkWG X X -SRC Src P12931 human CDC25A 993 P30304 CDC25A human Y486 57761917 SYCEPPSyRPMHHED X -SRC Src P12931 human GBF1 8729 Q92538 GBF1 human Y1514 1875829510 HTRAASIySSWAEEQ X -SRC Src P12931 human FAK 5747 Q05397 PTK2 human Y576 447889 RyMEDstyyKAsKGK PK_Tyr_Ser-Thr X 3281 -SRC Src P12931 human smMLCK 4638 Q15746 MYLK human Y471 451415 yEDAGsHyLCLLKAR I-set X -SRC Src P12931 human SORBS1 iso5 20411 Q62417-5 Sorbs1 mouse Y360 3782802 SEPPGYIySSNFHAV X -SRC Src P12931 human emerin 2010 P50402 EMD human Y59 463283 sssAAssysFsDLNs X X -SRC Src P12931 human HNF4 alpha 3172 P41235 HNF4A human Y286 22996302 LQIDDNEyAyLKAII Hormone_recep X X -SRC Src P12931 human CDK1 983 P06493 CDK1 human Y15 447610 EkIGEGtyGVVykGR Pkinase X 4539; 9111; 14566; 77897 -SRC Src P12931 human ARAF 369 P10398 ARAF human Y301 455521 LGyRDsGyyWEVPPS X -SRC Src P12931 human girdin 55704 Q3V6T2 CCDC88A human Y1765 450761 PRktEDtyFISSAGk X X -SRC Src P12931 human Src 6714 P12931 SRC human Y338 451705 VVSEEPIyIVTEyMS PK_Tyr_Ser-Thr X -SRC Src P12931 human GRK2 282682 P21146 GRK2 cow Y86 447727 AKPLVEFyEEIKKyE RGS X -SRC Src P12931 human LDH-A 3939 P00338 LDHA human Y10 454712 tLkDQLIyNLLkEEQ X X -SRC Src P12931 human IGF2BP1 303477 Q8CGX0 Igf2bp1 rat Y396 458348 SVTGAAPyGSFMQAP X -SRC Src P12931 human tensin 3 64759 Q68CZ2 TNS3 human Y1256 462739 kGCsNEPyFGsLtAL SH2 X X -SRC Src P12931 human FBP1 8880 Q96AE4 FUBP1 human Y625 473389 yyRQQAAyyAQtsPQ DUF1897 X -SRC Src P12931 human caveolin-1 12389 P49817 Cav1 mouse Y14 448422 VDsEGHLytVPIREQ X 3251 -SRC Src P12931 human calponin 2 1265 Q99439 CNN2 human Y12 6154129 QFNkGPsyGLsAEVk X -SRC Src P12931 human CBL 867 P22681 CBL human Y731 448530 QQIDSCTyEAMyNIQ X 3554 -SRC Src P12931 human CNK1 10256 Q969H4 CNKSR1 human Y26 50402000 LDDsLQDyPFEDWQL SAM_1 X -SRC Src P12931 human Fer 2241 P16591 FER human Y714 448461 RQEDGGVyssSGLkQ PK_Tyr_Ser-Thr X -SRC Src P12931 human STXBP1 20910 O08599 Stxbp1 mouse Y473 450386 ERISEQTyQLSRWtP Sec1 X -SRC Src P12931 human CLTC 1213 Q00610 CLTC human Y1477 448069 LFITEEDyQALRtSI Clathrin X -SRC Src P12931 human GRF-1 2909 Q9NRY4 ARHGAP35 human Y1105 448941 RNEEENIysVPHDst RhoGAP_pG1_pG2 X -SRC Src P12931 human CDH5 12562 P55284 Cdh5 mouse Y685 455658 MDARPAVyTQVQkPP X X -SRC Src P12931 human PAK1 5058 Q13153 PAK1 human S144 448170 sNsQKyMsFtDksAE X 2606 -SRC Src P12931 human profilin 1 513895 P02584 PFN1 cow Y129 450514 GMINKKCyEMASHLR Profilin X -SRC Src P12931 human IKKB 3551 O14920 IKBKB human Y199 449633 ELLEQQKyTVTVDYW Pkinase X -SRC Src P12931 human RSK2 6197 P51812 RPS6KA3 human Y488 464203 DVyDDGKyVYVVTEL Pkinase X X -SRC Src P12931 human hnRNP P2 2521 P35637 FUS human Y526 50318713 QDrrErPy_______ X -SRC Src P12931 human p53 7157 P04637 TP53 human Y126 34824802 AkSVTCTySPALNkM P53 X X -SRC Src P12931 human coronin 7 79585 P57737 CORO7 human Y712 1871177706 SERQLLLyEAEALAG X -SRC Src P12931 human Src 6714 P12931 SRC human Y419 448234 RLIEDNEytARQGAk PK_Tyr_Ser-Thr X X 2101; 6943; 59548; 70926; 78740; 94361; 17320 -SRC Src P12931 human Tks5 14218 O89032 Sh3pxd2a mouse Y557 458193 VKyEEPEyDVPAFGF X -SRC Src P12931 human ROCK2 19878 P70336 Rock2 mouse Y722 464192 LADKNKIyEsIEEAK X -SRC Src P12931 human TIAM1 21844 Q60610 Tiam1 mouse Y384 7362700 DRARQGVyENFRREL X X -SRC Src P12931 human CTNND1 12388 P30999 Ctnnd1 mouse Y96 449495 QDHNHLLystIPRMQ X -SRC Src P12931 human TR-beta1 7068 P10828 THRB human Y406 976541 FLLAFEHyINYRKHH Hormone_recep X X -SRC Src P12931 human WNK4 65266 Q96J92 WNK4 human Y1115 40407607 PVWMNySySSLCLSS X -SRC Src P12931 human STAT3 6774 P40763 STAT3 human Y45 464379 IESQDWAyAASkESH STAT_int X -SRC Src P12931 human NDFIP2 54602 Q9NV92 NDFIP2 human Y171 15229530 TEVyGEFyPVPPPyS DUF2370 X X -SRC Src P12931 human RHBG 57127 Q9H310 RHBG human Y429 3647000 SPPDSQHyEDQVHWQ X -SRC Src P12931 human Lasp-1 3927 Q14847 LASP1 human Y171 451675 IPtsAPVyQQPQQQP X -SRC Src P12931 human PRKD1 5587 Q15139 PRKD1 human Y463 448648 NDTGsRYyKEIPLSE PH X -SRC Src P12931 human DDR2 4921 Q16832 DDR2 human Y741 456863 NLysGDyyRIQGRAV PK_Tyr_Ser-Thr X -SRC Src P12931 human G3BP-1 10146 Q13283 G3BP1 human Y133 7366803 VHNDIFRyQDEVFGG NTF2 X -SRC Src P12931 human SHC3 iso2 53358 Q92529-2 SHC3 human Y301 451259 PTGEAPTyVNTQQIP X -SRC Src P12931 human Ezrin 7430 P15311 EZR human Y146 448758 kEVHksGyLSsERLI FERM_M X X -SRC Src P12931 human RAB34 83871 Q9BZG1 RAB34 human Y247 455172 NsDDsNLyLTASkKK X X -SRC Src P12931 human HRas 3265 P01112 HRAS human Y32 15228776 QNHFVDEyDPtIEDs Ras X -SRC Src P12931 human CEACAM1 634 P13688 CEACAM1 human Y493 447777 NKMNEVtysTLNFEA X X -SRC Src P12931 human hnRNP K 3190 P61978 HNRNPK human Y72 455999 IkALRTDyNAsVsVP KH_1 X X -SRC Src P12931 human FBP1 8880 Q96AE4 FUBP1 human Y58 454058 TsLNsNDyGyGGQkR X -SRC Src P12931 human FAK 14083 P34152 Ptk2 mouse Y861 447965 PTGNQHIyQPVGKPD X -SRC Src P12931 human SHC3 iso2 53358 Q92529-2 SHC3 human Y257 451256 AGKEQTyyQGRHLGD X -SRC Src P12931 human Etk 660 P51813 BMX human Y566 448067 RYVLDDQyVsSVGTK PK_Tyr_Ser-Thr X X -SRC Src P12931 human CTNNG 3728 P14923 JUP human Y644 456973 RNEGTATyAAAVLFR X -SRC Src P12931 human KHSRP 8570 Q92945 KHSRP human Y688 462454 yYRQQAAyYGQtPGP DUF1897 X -SRC Src P12931 human coronin 7 79585 P57737 CORO7 human Y738 1871177707 PSTLLPSyDPDTGLV X -SRC Src P12931 human GRK2 282682 P21146 GRK2 cow Y13 456872 AVLADVSyLMAMEKS X -SRC Src P12931 human GBF1 8729 Q92538 GBF1 human Y1488 1875829508 DEGVPASyHTVSLQV X -SRC Src P12931 human GJA1 24392 P08050 Gja1 rat Y247 447814 VKGRsDPyHATTGPL X X -SRC Src P12931 human PXN 5829 P49023 PXN human Y88 448909 PQsssPVyGsSAKTs Paxillin X -SRC Src P12931 human SHC3 iso2 53358 Q92529-2 SHC3 human Y283 451257 RQGSSDIySTPEGKL X -SRC Src P12931 human LRP1 4035 Q07954 LRP1 human Y4507 451245 TNFTNPVyATLyMGG X X -SRC Src P12931 human G-alpha t1 281794 P04695 GNAT1 cow Y142 470102 CFDRASEyQLNDSAG G-alpha X -SRC Src P12931 human Ku70 2547 P12956 XRCC6 human Y530 463414 DEFkELVyPPDyNPE Ku_C X -SRC Src P12931 human SHC3 iso2 53358 Q92529-2 SHC3 human Y219 451258 DGSDHPyyNSIPSKM X -SRC Src P12931 human Villin 7429 P09327 VIL1 human Y46 469582 SFFDGDCyIILAIHK Gelsolin X -SRC Src P12931 human FIP1L1 81608 Q6UN15 FIP1L1 human Y110 450990 IKTGAPQyGsyGTAP X -SRC Src P12931 human occludin Q91049 OCLN chicken Y383 458611 ESQyETDyTTAVESS X -SRC Src P12931 human ITGB3 3690 P05106 ITGB3 human Y785 448013 stFTNItyRGT____ Integrin_b_cyt X -SRC Src P12931 human NPHP1 4867 O15259 NPHP1 human Y721 18449509 FDLSEQTyDFLGEMR X -SRC Src P12931 human DAPP1 27071 Q9UN19 DAPP1 human Y139 448325 kVEEPsIyEsVRVHT X X 13703 -SRC Src P12931 human OTUB1 55611 Q96FW1 OTUB1 human Y26 14821305 EGVNCLAyDEAIMAQ X -SRC Src P12931 human EYA3 2140 Q99504 EYA3 human Y532 1870640407 RFGKkVTyVVIGDGR X -SRC Src P12931 human VAV1 22324 P27870 Vav1 mouse Y174 447866 EAEGDEIyEDLMRLE X -SRC Src P12931 human GAB1 2549 Q13480 GAB1 human Y627 447948 KGDKQVEyLDLDLDs X X 3231; 3233 -SRC Src P12931 human PKD1 5310 P98161 PKD1 human Y4237 466930 NQATEDVyQLEQQLH X -SRC Src P12931 human PKCD 170538 P09215 Prkcd rat Y372 464424 ELKGKERyFAIKYLK Pkinase X -SRC Src P12931 human PRMT5 10419 O14744 PRMT5 human Y324 1869973804 DNLESQTyEVFEkDP PRMT5 X X -SRC Src P12931 human GAK 2580 O14976 GAK human Y412 63063501 kGDLDISyITSRIAV X X -SRC Src P12931 human Kv4.3 3752 Q9UK17 KCND3 human Y108 23045802 GKLHYPRyECISAYD BTB_2 X -SRC Src P12931 human STAT1 6772 P42224 STAT1 human Y701 447754 DGPkGtGyIktELIs X 9174; 9167; 5375; 25685; 8062; 8183; 8009; 55603; 7649; 25809; 57216; 45118; 39205; 88845; 88211; 76285; 90145 -SRC Src P12931 human AKAP8 10270 O43823 AKAP8 human Y311 3582467 KRkQFQLyEEPDTkL X -SRC Src P12931 human NEDD4 iso4 4734 P46934-4 NEDD4 human Y111 36436802 GQVDVPLyPLPTENP C2 X X -SRC Src P12931 human ATP4A 397552 P19156 ATP4A pig Y10 484290 KAENyELyQVELGPG H-K_ATPase_N X -SRC Src P12931 human ANXA2 403435 Q6TEQ7 ANXA2 dog Y24 449483 HSTPPSAyGSVKAYT X -SRC Src P12931 human KIF11 3832 P52732 KIF11 human Y125 4251398 ERsPNEEytWEEDPL Kinesin X X -SRC Src P12931 human GBF1 8729 Q92538 GBF1 human Y1245 1875829504 RVSHQVAyGLHELLK X -SRC Src P12931 human ARHGEF4 iso3 50649 Q9NR80-3 ARHGEF4 human Y94 3333400 VGSEEDLyDDLHSSS X X -SRC Src P12931 human AKAP8 10270 O43823 AKAP8 human Y436 40420003 TVEFLQEyIVNRNKK AKAP95 X -SRC Src P12931 human MMP14 4323 P50281 MMP14 human Y573 478362 GtPRRLLyCQRsLLD DUF3377 X X -SRC Src P12931 human SRRT 51593 Q9BXP5 SRRT human Y175 7366810 AVKRyNDyKLDFRRQ SERRATE_Ars2_N X -SRC Src P12931 human IKKG 8517 Q9Y6K9 IKBKG human Y374 473650 PLPPAPAyLssPLAL X -SRC Src P12931 human CBL 12402 P22682 Cbl mouse Y780 448531 sENEDDGyDVPKPPV X 3555 -CSNK2A1 CK2A1 P33674 rabbit FKBP4 100009148 P27124 FKBP4 rabbit T143 451093 EFKGEDLtDDEDGGI X -CSNK2A1 CK2A1 P33674 rabbit 4E-BP1 116636 Q62622 Eif4ebp1 rat S111 447526 KRAGGEEsQFEMDI_ eIF_4EBP X -CSNK2A1 CK2A1 P33674 rabbit 4E-BP1 116636 Q62622 Eif4ebp1 rat S99 457415 ASQSHLHsSPEDKRA eIF_4EBP X -CSNK2A1 CK2A1 P33674 rabbit PKAR2A 518399 P00515 PRKAR2A cow S77 456583 DAVADsEsEDEEDLD X -CSNK2A1 CK2A1 P33674 rabbit Calmodulin 24242 P0DP29 Calm3 rat T118 469586 TNLGEkLtDEEVDEM EF-hand_7 X -CSNK2A1 CK2A1 P33674 rabbit Calmodulin 24242 P0DP29 Calm3 rat S102 448706 kDGNGyIsAAELRHV EF-hand_7 X -CSNK2A1 CK2A1 P33674 rabbit PKAR2A 518399 P00515 PRKAR2A cow S75 4702645 VADAVADsEsEDEED X -CSNK2A1 CK2A1 P33674 rabbit EIF5 56783 Q07205 Eif5 rat S388 448030 KEAEEEssGGEEEDE W2 X -CSNK2A1 CK2A1 P33674 rabbit Calmodulin 24242 P0DP29 Calm3 rat T80 448704 MARKMkDtDsEEEIR X -CSNK2A1 CK2A1 P33674 rabbit MYH13 100302407 Q9GJP9 MYH13 rabbit S2 451520 ______MssDAEMAI X -CSNK2A1 CK2A1 P33674 rabbit EIF5 56783 Q07205 Eif5 rat S387 448029 LKEAEEEssGGEEED W2 X -CSNK2A1 CK2A1 P33674 rabbit HSP90A 3320 P07900 HSP90AA1 human S263 448662 PEIEDVGsDEEEEKK HSP90 X -CSNK2A1 CK2A1 P33674 rabbit MYH13 100302407 Q9GJP9 MYH13 rabbit S3 451521 _____MssDAEMAIF X -CSNK2A1 CK2A1 P33674 rabbit EIF5 56783 Q07205 Eif5 rat S174 449998 DKENGSVsTSETPPP X -CSNK2A1 CK2A1 P33674 rabbit GYS1 100008660 P13834 GYS1 rabbit S657 449790 RHSsPHQsEDEEEPR Glycogen_syn X -CSNK2A1 CK2A1 P33674 rabbit Calmodulin 24242 P0DP29 Calm3 rat S82 448705 RKMkDtDsEEEIREA X -CSNK2A1 CK2A1 P33674 rabbit HSP90B 3326 P08238 HSP90AB1 human S226 454114 kEREKEIsDDEAEEE HSP90 X -CSNK2A1 CK2A1 P33674 rabbit HSP90B 3326 P08238 HSP90AB1 human S255 449266 PKIEDVGsDEEDDsG HSP90 X -TAOK3 TAO3 Q9H2K8 human DNCLI2 234663 Q6PDL0 Dync1li2 mouse T202 4739826 PQRRGPLtSGsDEDS DLIC X -Flt1 VEGFR1 P35969 mouse PLCG1 18803 Q62077 Plcg1 mouse Y783 447667 EGRNPGFyVEANPMP X 2821; 14461; 14008; 25678; 88717 -Plk3 PLK3 Q60806 mouse PTEN 5728 P60484 PTEN human S370 448649 TSVtPDVsDNEPDHy X -Plk3 PLK3 Q60806 mouse SNCA 20617 O55042 Snca mouse S129 448278 SEAyEMPsEEGYQDY Synuclein X 23706; 87281 -Plk3 PLK3 Q60806 mouse PTEN 5728 P60484 PTEN human T366 449634 ASSsTSVtPDVsDNE X -Plk3 PLK3 Q60806 mouse CDC25A 993 P30304 CDC25A human S519 26342101 KsKREMYsRLKKL__ X -Plk3 PLK3 Q60806 mouse CDC25A 993 P30304 CDC25A human S513 26342100 RtWAGEKsKREMYsR X -Atr ATR Q9JKK8 mouse MCM3 17215 P25206 Mcm3 mouse S732 475062 sQEKtDDsQEtQDsQ X -Atr ATR Q9JKK8 mouse VAMP2 22318 P63044 Vamp2 mouse T35 12473004 SNRRLQQtQAQVDEV Synaptobrevin X -Atr ATR Q9JKK8 mouse MCM3 17215 P25206 Mcm3 mouse S725 475061 HtPKtDDsQEKtDDs X -Atr ATR Q9JKK8 mouse MCM3 4172 P25205 MCM3 human S728 475062 HtPKtADsQETkEsQ X -Atr ATR Q9JKK8 mouse p53 22059 P02340 Tp53 mouse S18 447490 IsLELPLsQEtFsGL P53_TAD X 9284; 9286; 12571; 56979 -Atr ATR Q9JKK8 mouse CREB 12912 Q01147 Creb1 mouse S107 451811 sVDsVTDsQKRREIL pKID X -Cilk1 ICK Q9JKV2 mouse KIF3A 16568 P28741 Kif3a mouse T674 33668514 MKLERPRtSKGKARP X X -Abl2 Arg Q4JIM5 mouse Arg 11352 Q4JIM5 Abl2 mouse Y272 456540 KCNKPTVyGVSPIHD X -Abl2 Arg Q4JIM5 mouse Arg 11352 Q4JIM5 Abl2 mouse Y439 447923 RLMTGDTytAHAGAK PK_Tyr_Ser-Thr X -Abl2 Arg Q4JIM5 mouse Arg 11352 Q4JIM5 Abl2 mouse Y568 456545 SSSSVVPyLPrLPLL X -Abl2 Arg Q4JIM5 mouse N-WASP 8976 O00401 WASL human Y256 450253 RETSkVIyDFIEkTG PBD X X -Abl2 Arg Q4JIM5 mouse Arg 11352 Q4JIM5 Abl2 mouse Y684 456546 ENQPHKKyELTGNFS X -Grk5 GRK5 Q8VEB1 mouse KOR-1 18387 P33534 Oprk1 mouse S369 449609 NtVQDPAsMRDVGGM X -Grk5 GRK5 Q8VEB1 mouse KOR-1 18387 P33534 Oprk1 mouse T357 52467201 MRMERQstNRVRNtV X -Grk5 GRK5 Q8VEB1 mouse KOR-1 18387 P33534 Oprk1 mouse S356 52467200 KMRMERQstNRVRNt X -Grk5 GRK5 Q8VEB1 mouse MOR-1 18390 P42866 Oprm1 mouse S375 447784 QNtREHPstANtVDR X 3451 -Grk5 GRK5 Q8VEB1 mouse KOR-1 18387 P33534 Oprk1 mouse T363 52467202 stNRVRNtVQDPAsM X -PIK3CB PIK3CB P42338 human PIK3CB 5291 P42338 PIK3CB human S1070 449881 TVRKDYRs_______ X -CDK3 CDK3 Q00526 human ER-alpha 2099 P03372 ESR1 human S104 448099 FPPLNsVsPsPLMLL Oest_recep X X -CDK3 CDK3 Q00526 human TFCP2 7024 Q12800 TFCP2 human S309 7965105 SLGEGNGsPNHQPEP X X -CDK3 CDK3 Q00526 human EVI1 2122 Q03112 MECOM human S624 4702996 KMFKDkVsPLQNLAS X -CDK3 CDK3 Q00526 human LIN9 286826 Q5TKA1 LIN9 human T96 3201645 KFtAtMstPDKKASQ X X -CDK3 CDK3 Q00526 human NFAT3 4776 Q14934 NFATC4 human S259 31859079 APGPtPAsPRPAsPC X -CDK3 CDK3 Q00526 human ER-alpha 2099 P03372 ESR1 human S118 448101 LHPPPQLsPFLQPHG Oest_recep X X 2511 -CDK3 CDK3 Q00526 human Notch 1 4851 P46531 NOTCH1 human S2513 35483201 EHPFLtPsPEsPDQW X X -CDK3 CDK3 Q00526 human Notch 1 4851 P46531 NOTCH1 human T2511 483083 VPEHPFLtPsPEsPD X X -CDK3 CDK3 Q00526 human C/EBP-beta 24253 P21272 Cebpb rat T189 447878 SSSsPPGtPSPADAK X 3084 -CDK3 CDK3 Q00526 human ER-alpha 2099 P03372 ESR1 human S106 448100 PLNsVsPsPLMLLHP Oest_recep X X -CDK3 CDK3 Q00526 human Jun 3725 P05412 JUN human S73 447943 VGLLkLAsPELERLI Jun X X 9164; 3270; 8752; 12714; 77955 -CDK3 CDK3 Q00526 human ATF-1 466 P18846 ATF1 human S63 449762 GILARRPsyRKILkD pKID X X 4095; 14228; 14001 -CDK3 CDK3 Q00526 human Jun 3725 P05412 JUN human S63 447686 kNsDLLtsPDVGLLk Jun X X 5464; 9261; 2361; 97721; 91952 -CDK3 CDK3 Q00526 human CABLES1 91768 Q8TDN4 CABLES1 human S313 4274722 RCRtLsGsPRPKNFK X X -CDK3 CDK3 Q00526 human Rb 5925 P06400 RB1 human S807 447980 PGGNIyIsPLksPyk Rb_C X 9308; 8974; 4277; 40283; 8957; 8516; 11917; 99274; 41359; 75864; 72443 -CDK3 CDK3 Q00526 human Notch 1 4851 P46531 NOTCH1 human S2516 35483202 FLtPsPEsPDQWsss X -CDK3 CDK3 Q00526 human Rb 5925 P06400 RB1 human S811 448717 IyIsPLksPykIsEG Rb_C X 9308; 8974; 4277; 40283; 8957; 8516; 11917; 41359; 75864; 63276 -WNK2 WNK2 Q9Y3S1 human WNK1 65125 Q9H4A3 WNK1 human S382 454105 kRAsFAKsVIGTPEF Pkinase X -WNK2 WNK2 Q9Y3S1 human STLK3 27347 Q9UEW8 STK39 human T354 483899 IEkLLtRtPDIAQRA X -WNK2 WNK2 Q9Y3S1 human STLK3 27347 Q9UEW8 STK39 human S371 456506 VRRVPGssGHLHKTE X -Mapk11 P38B Q9WUI1 mouse E2F1 1869 Q01094 E2F1 human T433 447871 DCDFGDLtPLDF___ X -Mapk11 P38B Q9WUI1 mouse E2F1 1869 Q01094 E2F1 human S403 447870 PEEFISLsPPHEALD X -Mapk11 P38B Q9WUI1 mouse MAPKAPK5 17165 O54992 Mapkapk5 mouse T182 450093 VDQGDLMtPQFTPYY Pkinase X -Mapk11 P38B Q9WUI1 mouse SMARCD3 66993 Q6P9Z1 Smarcd3 mouse T229 8097074 HLVEWHRtPTTQETD X -Csnk2a1 CK2A1 Q60737 mouse CD45 19264 P06800 Ptprc mouse S993 449973 SEPEsDEssDDDsDS Y_phosphatase X X -Csnk2a1 CK2A1 Q60737 mouse CUTL1 13047 P53564 Cux1 mouse S1155 457411 ILGLTQGsVSDLLAR CUT X -Csnk2a1 CK2A1 Q60737 mouse POLR2A 20020 P08775 Polr2a mouse S1616 450204 TPQSPSYsPtsPSYS RNA_pol_Rpb1_R X 4735; 13499; 13546; 31262 -Csnk2a1 CK2A1 Q60737 mouse CUTL1 13047 P53564 Cux1 mouse S972 457410 VLGLSQGsVSDMLSR CUT X -Csnk2a1 CK2A1 Q60737 mouse Myb 396244 P01103 MYB chicken S12 448187 PRHSIYssDDDEEDV X -Csnk2a1 CK2A1 Q60737 mouse HSF1 15499 P38532 Hsf1 mouse T142 449066 DSVTRLLtDVQLMKG X -Csnk2a1 CK2A1 Q60737 mouse SIRT1 93759 Q923E4 Sirt1 mouse S164 6006904 DDRTSHAsSSDWTPR X X -Csnk2a1 CK2A1 Q60737 mouse DARPP-32 19049 Q60829 Ppp1r1b mouse S97 457675 NLsENQAsEEEDELG DARPP-32 X 3401 -Csnk2a1 CK2A1 Q60737 mouse CUTL1 13047 P53564 Cux1 mouse S583 457409 VLGLSQGsVSEILAR CUT X -Csnk2a1 CK2A1 Q60737 mouse HP1 alpha 12419 Q61686 Cbx5 mouse S11 476162 KTKRtADssssEDEE X -Csnk2a1 CK2A1 Q60737 mouse CACNA1A 12286 P97445 Cacna1a mouse S2363 4713052 AHDAYsEsEDDWC__ X -Csnk2a1 CK2A1 Q60737 mouse PPPM1A 19042 P49443 Ppm1a mouse S375 452154 YKNDDtDsAstDDMW X -Csnk2a1 CK2A1 Q60737 mouse p53 22059 P02340 Tp53 mouse S389 447535 VkkVGPDsD______ X X 9281 -Csnk2a1 CK2A1 Q60737 mouse Cortactin 13043 Q60598 Cttn mouse T24 471533 GGADDWEtDPDFVND X -Csnk2a1 CK2A1 Q60737 mouse MYBPC3 17868 O70468 Mybpc3 mouse S327 30324204 ILRQAPPsEYERIAF THB X -Csnk2a1 CK2A1 Q60737 mouse CASP9 12371 Q8C3Q9 Casp9 mouse S348 484609 SQGRTLDsDSEPDAV Peptidase_C14 X -Csnk2a1 CK2A1 Q60737 mouse CTNNB1 1499 P35222 CTNNB1 human T393 449562 RNLSDAAtkQEGMEG X -Csnk2a1 CK2A1 Q60737 mouse MYBPC3 17868 O70468 Mybpc3 mouse S47 4699355 VRWQRDGsDItANDK I-set X -Csnk2a1 CK2A1 Q60737 mouse BID 12122 P70444 Bid mouse T58 448406 DLEDELQtDGsQAsR BID X -Csnk2a1 CK2A1 Q60737 mouse PAX3 18505 P24610 Pax3 mouse S205 4145506 APQsDEGsDIDsEPD X -Csnk2a1 CK2A1 Q60737 mouse Myb 396244 P01103 MYB chicken S11 448186 RPRHSIYssDDDEED X -Csnk2a1 CK2A1 Q60737 mouse CD45 19264 P06800 Ptprc mouse S990 449972 SKESEPEsDEssDDD Y_phosphatase X X -Csnk2a1 CK2A1 Q60737 mouse HP1 alpha 12419 Q61686 Cbx5 mouse S14 476165 RtADssssEDEEEyV X -Csnk2a1 CK2A1 Q60737 mouse MYBPC3 17868 O70468 Mybpc3 mouse S72 4699361 tLTVRDAsPDDQGSY I-set X -Csnk2a1 CK2A1 Q60737 mouse NRL 4901 P54845 NRL human S117 1880112600 PHGYYPGsPEETGAQ X -Csnk2a1 CK2A1 Q60737 mouse BMAL1 11865 Q9WTL8 Bmal1 mouse S97 7359500 RRRDKMNsFIDELAS HLH X -Csnk2a1 CK2A1 Q60737 mouse CACNA1A 12286 P97445 Cacna1a mouse S2361 4713048 RGAHDAYsEsEDDWC X -Csnk2a1 CK2A1 Q60737 mouse IkB-alpha 18035 Q9Z1E3 Nfkbia mouse S293 451525 EESYDTEsEFTEDEL X -Csnk2a1 CK2A1 Q60737 mouse ODC 18263 P00860 Odc1 mouse S303 451283 VWKEQPGsDDEDESN Orn_DAP_Arg_deC X -Csnk2a1 CK2A1 Q60737 mouse SNCA 6622 P37840 SNCA human S129 448278 NEAyEMPsEEGyQDy Synuclein X 23706; 87281 -Csnk2a1 CK2A1 Q60737 mouse BMAL1 iso4 11865 Q9WTL8-4 Bmal1 mouse S90 7359500 RRRDKMNsFIDELAS HLH X -Csnk2a1 CK2A1 Q60737 mouse SNCA 20617 O55042 Snca mouse S129 448278 SEAyEMPsEEGYQDY Synuclein X 23706; 87281 -Csnk2a1 CK2A1 Q60737 mouse Ikaros 22778 Q03267 Ikzf1 mouse T23 4828303 ESPPVSDtPDEGDEP X -Csnk2a1 CK2A1 Q60737 mouse HP1 alpha 12419 Q61686 Cbx5 mouse S97 4730523 RkssFsNsADDIkSK X -Csnk2a1 CK2A1 Q60737 mouse NFE2L1 18023 Q61985 Nfe2l1 mouse S497 28700306 EGAVGYSsDSETLDL X -Csnk2a1 CK2A1 Q60737 mouse MYBPC3 17868 O70468 Mybpc3 mouse S25 30324201 SAEVTAGsAAVFEAE I-set X -Csnk2a1 CK2A1 Q60737 mouse MYBPC3 17868 O70468 Mybpc3 mouse S282 471080 AGAGRRtsDsHEDAG X -Csnk2a1 CK2A1 Q60737 mouse LPIN1 14245 Q91ZP3 Lpin1 mouse S285 471346 SRPstPKsDsELVSK X -Csnk2a1 CK2A1 Q60737 mouse MYBPC3 17868 O70468 Mybpc3 mouse T50 30324202 QRDGsDItANDKYGL I-set X -Csnk2a1 CK2A1 Q60737 mouse Ikaros 22778 Q03267 Ikzf1 mouse S293 15404028 LSDMPYDsANYEKED X -Csnk2a1 CK2A1 Q60737 mouse HP1 alpha 12419 Q61686 Cbx5 mouse S12 3190486 TKRtADssssEDEEE X -Csnk2a1 CK2A1 Q60737 mouse PU.1 20375 P17433 Spi1 mouse S148 455900 QsPPLEVsDGEADGL X -Csnk2a1 CK2A1 Q60737 mouse Nur77 15370 P12813 Nr4a1 mouse S151 1255792405 STPNFQPsQLSPWDG X -Csnk2a1 CK2A1 Q60737 mouse PPPM1A 19042 P49443 Ppm1a mouse S377 452155 NDDtDsAstDDMW__ X -Csnk2a1 CK2A1 Q60737 mouse Myb 17863 P06876 Myb mouse S11 448186 RPRHSIYssDEDDED X -Csnk2a1 CK2A1 Q60737 mouse PAX3 18505 P24610 Pax3 mouse S209 18744501 DEGsDIDsEPDLPLK X -Csnk2a1 CK2A1 Q60737 mouse CD45 19264 P06800 Ptprc mouse S994 449974 EPEsDEssDDDsDSE Y_phosphatase X X -Csnk2a1 CK2A1 Q60737 mouse POLR2A 20020 P08775 Polr2a mouse S1619 447616 SPSYsPtsPSYSPTS RNA_pol_Rpb1_R X 4735; 13523; 13546; 67221 -Csnk2a1 CK2A1 Q60737 mouse LRP6 16974 O88572 Lrp6 mouse S1579 23122945 tPRSQYLsAEENYES X X -Csnk2a1 CK2A1 Q60737 mouse Ikaros 22778 Q03267 Ikzf1 mouse S101 4828301 GSHRDQGsSALSGVG X -Csnk2a1 CK2A1 Q60737 mouse CD45 19264 P06800 Ptprc mouse S998 449975 DEssDDDsDSEETSK Y_phosphatase X X -Csnk2a1 CK2A1 Q60737 mouse HP1 alpha 12419 Q61686 Cbx5 mouse S13 476164 KRtADssssEDEEEy X -Csnk2a1 CK2A1 Q60737 mouse TRPM3 226025 Q5F4S9 Trpm3 mouse S1184 1875848400 CRWRKHEsDQDERDY X X -Csnk2a1 CK2A1 Q60737 mouse Myb 17863 P06876 Myb mouse S12 448187 PRHSIYssDEDDEDI X -Csnk2a1 CK2A1 Q60737 mouse HDAC2 15182 P70288 Hdac2 mouse S394 449930 EDAVHEDsGDEDGED X 61458; 69238 -Csnk2a1 CK2A1 Q60737 mouse PTEN 19211 O08586 Pten mouse S370 448649 TSVtPDVsDNEPDHY X -Csnk2a1 CK2A1 Q60737 mouse MYBPC3 17868 O70468 Mybpc3 mouse T33 30324200 AAVFEAEtERSGVMV I-set X -Csnk2a1 CK2A1 Q60737 mouse FMR1 14265 P35922 Fmr1 mouse S499 469583 NSEAsNAsETESDHR FXMRP1_C_core X -Csnk2a1 CK2A1 Q60737 mouse LPIN1 14245 Q91ZP3 Lpin1 mouse S287 471347 PstPKsDsELVSKsA X -Csnk2a1 CK2A1 Q60737 mouse VAMP4 53330 O70480 Vamp4 mouse S30 454285 RNLLEDDsDEEEDFF X -Csnk2a1 CK2A1 Q60737 mouse KLF1 16596 P46099 Klf1 mouse T23 457383 TLGQFLDtQEDFLKW EKLF_TAD1 X X -Csnk2a1 CK2A1 Q60737 mouse MYBPC3 17868 O70468 Mybpc3 mouse S105 17660717 APPEkAEsEVAPGAP X -Csnk2a1 CK2A1 Q60737 mouse HDAC6 10013 Q9UBN7 HDAC6 human S458 18944908 EEDNVEEsEEEGPWE X -Csnk2a1 CK2A1 Q60737 mouse CACYBP 12301 Q9CXW3 Cacybp mouse T184 15402545 KEKPSYDtEADPSEG SGS X -Csnk2a1 CK2A1 Q60737 mouse MEF2C 17260 Q8CFN5 Mef2c mouse S59 447999 NKLFQYAsTDMDKVL X -Csnk2a1 CK2A1 Q60737 mouse Ikaros 22778 Q03267 Ikzf1 mouse S13 4828300 GQDMSQVsGKESPPV X -Csnk2a1 CK2A1 Q60737 mouse C/EBP-beta 24253 P21272 Cebpb rat S223 408589401 kkAVDKLsDEYKMRR bZIP_2 X -NTRK2 TrkB Q16620 human TrkB 4915 Q16620 NTRK2 human Y516 448813 PVIENPQyFGITNSQ X 4619 -NTRK2 TrkB Q16620 human PAX5 18507 Q02650 Pax5 mouse Y102 34364233 VVEKIAEyKRQNPTM PAX X X -NTRK2 TrkB Q16620 human SHC3 iso2 53358 Q92529-2 SHC3 human Y218 451254 GDGSDHPyyNSIPSK X -NTRK2 TrkB Q16620 human SHC3 iso2 53358 Q92529-2 SHC3 human Y256 451255 FAGKEQTyyQGRHLG X -NTRK2 TrkB Q16620 human Kv1.3 3738 P22001 KCNA3 human Y499 451294 EGEEQSQyMHVGsCQ X -NTRK2 TrkB Q16620 human Kv1.3 3738 P22001 KCNA3 human Y161 3820926 PSFDAILyyyQSGGR BTB_2 X -NTRK2 TrkB Q16620 human NLGN1 192167 Q99K10 Nlgn1 mouse Y782 1008111 RTACPPDyTLAMRRS X -NTRK2 TrkB Q16620 human Kv1.3 3738 P22001 KCNA3 human Y162 3820931 SFDAILyyyQSGGRI BTB_2 X -NTRK2 TrkB Q16620 human SHC3 iso2 53358 Q92529-2 SHC3 human Y301 451259 PTGEAPTyVNTQQIP X -NTRK2 TrkB Q16620 human SHC3 iso2 53358 Q92529-2 SHC3 human Y257 451256 AGKEQTyyQGRHLGD X -NTRK2 TrkB Q16620 human SHC3 iso2 53358 Q92529-2 SHC3 human Y283 451257 RQGSSDIySTPEGKL X -NTRK2 TrkB Q16620 human SHC3 iso2 53358 Q92529-2 SHC3 human Y219 451258 DGSDHPyyNSIPSKM X -NTRK2 TrkB Q16620 human Kv1.3 3738 P22001 KCNA3 human Y163 3820936 FDAILyyyQSGGRIR BTB_2 X -RPS6KA4 MSK2 O75676 human H3 360198 P68433 H3c1 mouse S10 455676 tkQTARkstGGkAPr Histone X 9701; 9711; 9606; 3465; 3642; 3377; 3475; 3458; 5764; 47398; 8481; 8552; 53348; 29237; 66065; 43185; 64522; 52725 -RPS6KA4 MSK2 O75676 human H3 8350 P68431 H3C1 human S28 455677 ATkAArksAPATGGV Histone X 9713 -RPS6KA4 MSK2 O75676 human H3 360198 P68433 H3c1 mouse K14 458954 ARkstGGkAPrkQLA Histone X 9677; 7627; 26828 -RPS6KA4 MSK2 O75676 human CREB 1385 P16220 CREB1 human S119 448228 EILsRRPsyRkILND pKID X 9187; 9196; 9198; 4095; 14228; 14001; 39561; 80120; 44864; 54960; 95995 -RPS6KA4 MSK2 O75676 human ataxin-1 6310 P54253 ATXN1 human S775 449110 AtRKRRWsAPESRKL X -RPS6KA4 MSK2 O75676 human NFkB-p65 5970 Q04206 RELA human S276 447798 sMQLRRPsDRELsEP RHD_dimer X -RPS6KA4 MSK2 O75676 human MSK2 8986 O75676 RPS6KA4 human S196 450046 EEkERtFsFCGTIEY Pkinase X -PRKACA PKACA P36887 pig FBPase 24362 P19112 Fbp1 rat S357 449856 AREsPVHsICDELF_ X -PRKACA PKACA P36887 pig FBPase 24362 P19112 Fbp1 rat S339 451645 YNkDKAKsRPsLPLP X -PRKACA PKACA P36887 pig CACNA1C BAA34185.2 CACNA1C guinea pig S1574 467228 VACKRLVsMNMPLNS GPHH X -PRKACA PKACA P36887 pig PAH 24616 P04176 Pah rat S16 449074 GVLSRKLsDFGQETS X -PRKACA PKACA P36887 pig H3 8350 P68431 H3C1 human S10 455676 tkQtArkstGGkAPr Histone X 9701; 9711; 9606; 3465; 3642; 3377; 3475; 3458; 5764; 47398; 8481; 8552; 53348; 29237; 66065; 43185; 64522; 52725 -PRKACA PKACA P36887 pig CAMKK1 84254 Q8N5S9 CAMKK1 human S74 452115 sLsARkLsLQERPAG X -PRKACA PKACA P36887 pig FBPase 24362 P19112 Fbp1 rat S342 449869 DKAKsRPsLPLPQSR X -PRKACA PKACA P36887 pig CAMKK1 84254 Q8N5S9 CAMKK1 human S475 486103 RrEErsMsAPGNLLV X -PRKACA PKACA P36887 pig GFAP 396562 F1RR02 GFAP pig S8 449618 MERRRVtsAARRsYV Filament_head X -PRKACA PKACA P36887 pig CACNA1C BAA34185.2 CACNA1C guinea pig S1699 4714250 PEIRRAIsGDLTAEE CAC1F_C X -PRKACA PKACA P36887 pig CACNA1C BAA34185.2 CACNA1C guinea pig S1626 10349704 KKIWKRTsMKLLDQV Ca_chan_IQ X -PRKACA PKACA P36887 pig FGF2 2247 P09038 FGF2 human T254 451676 TYRsRKytSWYVALk FGF X -PRKACA PKACA P36887 pig HMGN1 614915 P02316 HMGN1 cow S7 447788 _MPKRKVsSAEGAAK HMG14_17 X -PRKACA PKACA P36887 pig GFAP 396562 F1RR02 GFAP pig S34 449621 LGPGPRLsLARMPPP Filament_head X -PRKACA PKACA P36887 pig PKACA P36887 PRKACA pig S11 469998 AAAAKKGsEQESVKE X -PRKACA PKACA P36887 pig myomesin 1 8736 P52179 MYOM1 human S618 451407 ARLKSRPsAPWTGQI X -PRKACA PKACA P36887 pig GFAP 396562 F1RR02 GFAP pig T7 449617 _MERRRVtsAARRsY Filament_head X -PRKACA PKACA P36887 pig PKACA P36887 PRKACA pig S339 449886 EEEEIRVsINEKCGK X -PRKACA PKACA P36887 pig GFAP 396562 F1RR02 GFAP pig S13 449619 VtsAARRsYVSSLET Filament_head X -PRKACA PKACA P36887 pig TRIM32 22954 Q13049 TRIM32 human S651 27717300 SYHLRRYsTP_____ X -ILK ILK Q13418 human MYPT1 396020 Q90623 PPP1R12A chicken T709 3073900 DLQEAEKtIGRSRSt X -ILK ILK Q13418 human Akt1 207 P31749 AKT1 human S473 447855 RPHFPQFsysAsGtA Pkinase_C X X 9271; 3787; 4060; 4051; 5102; 4058; 2336; 2337; 4075; 4070; 5012; 4071; 92982; 5315; 9563; 9018; 12694; 52240; 11962; 15116; 88106; 26580; 68035; 31957; 23430; 20235 -ILK ILK Q13418 human PPP1R14A 94274 Q96A00 PPP1R14A human T38 449098 QkRHARVtVkYDRRE PP1_inhibitor X -ILK ILK Q13418 human KEPI 81706 Q8TAE6 PPP1R14C human T73 10296602 RHQQGKVtVkYDRKE PP1_inhibitor X -ILK ILK Q13418 human MYPT1 396020 Q90623 PPP1R12A chicken T695 448587 ARQSRRstQGVTLTD X 5163 -ILK ILK Q13418 human Cofilin-1 29271 P45592 Cfl1 rat S3 448444 _____MAsGVAVsDG X 3313; 3311 -ILK ILK Q13418 human MRLC2 103910 O14950 MYL12B human S20 448595 KRPQRAtsNVFAMFD X X -ILK ILK Q13418 human NACA 4666 E9PAV3 NACA human S1906 454238 PELEEQDsTQATTQQ X X -ILK ILK Q13418 human Akt1 11651 P31750 Akt1 mouse S473 447855 RPHFPQFsysAsGtA Pkinase_C X 9271; 3787; 4060; 4051; 5102; 4058; 2336; 2337; 4075; 4070; 5012; 4071; 92982; 5315; 9563; 9018; 12694; 52240; 11962; 15116; 88106; 26580; 68035; 31957; 23430; 20235 -ILK ILK Q13418 human PPP1R14B 26472 Q96C90 PPP1R14B human T57 1904503 VRRQGKVtVkYDRKE PP1_inhibitor X -ILK ILK Q13418 human MYPT1 396020 Q90623 PPP1R12A chicken T495 1856024 RLAYVAPtIPRRLAS X -ILK ILK Q13418 human MRLC2 103910 O14950 MYL12B human T19 448596 KKRPQRAtsNVFAMF X -GRK5 GRK5 P43249 cow GRK5 281801 P43249 GRK5 cow S484 451511 VLDIEQFstVKGVNL X -GRK5 GRK5 P43249 cow ADRB2 154 P07550 ADRB2 human S355 458916 KAyGNGyssNGNtGE X -GRK5 GRK5 P43249 cow ADRB2 154 P07550 ADRB2 human S356 458917 AyGNGyssNGNtGEQ X -GRK5 GRK5 P43249 cow GRK5 281801 P43249 GRK5 cow T485 451512 LDIEQFstVKGVNLD X -TESK1 TESK1 Q15569 human Cofilin-1 1072 P23528 CFL1 human S3 448444 _____MAsGVAVsDG X 3313; 3311 -VRK1 VRK1 Q99986 human VRK1 7443 Q99986 VRK1 human S376 15416617 GVEDTEWsNtQtEEA X -VRK1 VRK1 Q99986 human coilin 8161 P38432 COIL human S184 11329300 NEEAKRKsPKKKEKC Coilin_N X X -VRK1 VRK1 Q99986 human p53 7157 P04637 TP53 human T18 447541 EPPLsQEtFsDLWkL P53_TAD X X 2529 -VRK1 VRK1 Q99986 human H3 8350 P68431 H3C1 human T3 455678 _____ArtkQtArks Histone X X 9714; 13576 -VRK1 VRK1 Q99986 human H3 8350 P68431 H3C1 human S10 455676 tkQtArkstGGkAPr Histone X X 9701; 9711; 9606; 3465; 3642; 3377; 3475; 3458; 5764; 47398; 8481; 8552; 53348; 29237; 66065; 43185; 64522; 52725 -VRK1 VRK1 Q99986 human ATF-2 1386 P15336 ATF2 human T73 451439 ADQtPtPtRFLkNCE X X -VRK1 VRK1 Q99986 human BAF 8815 O75531 BANF1 human S4 458302 ____MttsQkHRDFV BAF X X -VRK1 VRK1 Q99986 human BAF 8815 O75531 BANF1 human T3 7105313 _____MttsQkHRDF BAF X X -VRK1 VRK1 Q99986 human VRK1 7443 Q99986 VRK1 human T386 1868585000 QtEEAIQtRSRTRKR X X -VRK1 VRK1 Q99986 human Jun 3725 P05412 JUN human S73 447943 VGLLkLAsPELERLI Jun X X 9164; 3270; 8752; 12714; 77955 -VRK1 VRK1 Q99986 human ATF-2 1386 P15336 ATF2 human S62 451440 FGPARNDsVIVADQt X X -VRK1 VRK1 Q99986 human p53 22059 P02340 Tp53 mouse T21 447541 ELPLsQEtFsGLWKL P53_TAD X -VRK1 VRK1 Q99986 human H2A.1 8329 P0C0S8 H2AC17 human T120 482914 AVLLPkktEsHHkAk Histone_H2A_C X X -VRK1 VRK1 Q99986 human Jun 3725 P05412 JUN human S63 447686 kNsDLLtsPDVGLLk Jun X X 5464; 9261; 2361; 97721; 91952 -VRK1 VRK1 Q99986 human PXR 8856 O75469 NR1I2 human S350 4668103 MQAISLFsPDRPGVL Hormone_recep X X -VRK1 VRK1 Q99986 human BAF 8815 O75531 BANF1 human T2 7105310 ______MttsQkHRD BAF X X -VRK1 VRK1 Q99986 human Tip60 10524 Q92993 KAT5 human T158 10800707 VEVVsPAtPVPSETA X -VRK1 VRK1 Q99986 human VRK1 7443 Q99986 VRK1 human T355 483969 GLkAKTItKKRKKEI X -Tie1 TIE1 Q06806 mouse TIE1 21846 Q06806 Tie1 mouse Y1113 451279 MLEARKAyVNMSLFE X X -PRKCI PKCI P41743 human MARK2 2011 Q7KZI7 MARK2 human T596 453427 rGVssRstFHAGQLR X -PRKCI PKCI P41743 human AMOT 154796 Q4VCS5 AMOT human T750 56589712 DMEGRIKtLHAQIIE Angiomotin_C X -PRKCI PKCI P41743 human Tau iso8 4137 P10636-8 MAPT human S352 487459 DFKDrVQskIGsLDN Tubulin-binding X -PRKCI PKCI P41743 human ROCK1 6093 Q13464 ROCK1 human T1334 1210778 AsPRtLstRstANQs X X -PRKCI PKCI P41743 human Ezrin 7430 P15311 EZR human T567 448104 QGRDkyKtLRQIRQG ERM_C X X 3141; 3726; 32600 -PRKCI PKCI P41743 human SP1 6667 P08047 SP1 human S59 452233 GGQEsQPsPLALLAA X -PRKCI PKCI P41743 human ROCK1 6093 Q13464 ROCK1 human S1333 4935818 RAsPRtLstRstANQ X X -PRKCI PKCI P41743 human NUMB 8650 P49757 NUMB human S295 470030 sPFKRQLsLRINELP NumbF X -PRKCI PKCI P41743 human MARK3 4140 P27448 MARK3 human T564 466001 RGTASRStFHGQPRE X -PRKCI PKCI P41743 human CDK7 1022 P50613 CDK7 human T170 448306 GsPNRAytHQVVtRW Pkinase X X -PRKCI PKCI P41743 human GLI1 2735 P08151 GLI1 human S243 27708601 DCRWDGCsQEFDSQE X -PRKCI PKCI P41743 human AID 11628 Q9WVE0 Aicda mouse S3 20660600 _____MDsLLMKQKK X -PRKCI PKCI P41743 human Ezrin 22350 P26040 Ezr mouse T567 448104 QGRDKYKtLRQIRQG ERM_C X X 3141; 3726; 32600 -PRKCI PKCI P41743 human ROCK1 6093 Q13464 ROCK1 human T1337 18261228 RtLstRstANQsFRK X X -PRKCI PKCI P41743 human NUMB 8650 P49757 NUMB human S7 487518 _MNKLRQsFRRKkDV X X -PRKCI PKCI P41743 human NUMB 8650 P49757 NUMB human S276 456490 EQLARQGsFrGFPAL NumbF X 4140; 9878 -PRKCI PKCI P41743 human Tau iso8 4137 P10636-8 MAPT human S324 449328 kVtskCGsLGNIHHk Tubulin-binding X -PRKCI PKCI P41743 human KEPI 81706 Q8TAE6 PPP1R14C human T73 10296602 RHQQGKVtVkYDRKE PP1_inhibitor X -PRKCI PKCI P41743 human FBXW7 55294 Q969H0 FBXW7 human S10 17337000 QELLSVGsKRRRTGG X -PRKCI PKCI P41743 human DOC2B 8447 Q14184 DOC2B human S34 1267669105 IRPIKQIsDYFPRFP X X -PRKCI PKCI P41743 human FBXW7 55294 Q969H0 FBXW7 human S18 17337001 KRRRTGGsLRGNPSs X -PRKCI PKCI P41743 human ROCK1 6093 Q13464 ROCK1 human T1024 20609219 IDRKKANtQDLRKKE X X -PRKCI PKCI P41743 human Tau iso8 4137 P10636-8 MAPT human S293 449327 NVQskCGsKDNIkHV Tubulin-binding X -PRKCI PKCI P41743 human BAD 572 Q92934 BAD human S99 447862 PFrGrsRsAPPNLWA Bcl-2_BAD X X 9295; 5286; 4366 -PRKCI PKCI P41743 human UBF 7343 P17480 UBTF human S412 472620 EkPKRPVsAMFIFSE HMG_box X X -PRKCI PKCI P41743 human IRAK1 16179 Q62406 Irak1 mouse T66 447722 CERSEQRtASVLWPW Death X -PRKCI PKCI P41743 human ELF3 1999 P78545 ELF3 human S68 54363505 GEQPQFWsKTQVLDW SAM_PNT X -PRKCI PKCI P41743 human PARD6A 50855 Q9NPB6 PARD6A human S345 15714600 RGDGSGFsL______ X -PRKCI PKCI P41743 human ECT2 1894 Q9H8V3 ECT2 human T359 483847 YLYEKANtPELKksV X X -PRKCI PKCI P41743 human AMOT 154796 Q4VCS5 AMOT human T536 56589713 GSEDTRKtIsQLFAK X -PRKCI PKCI P41743 human GLI1 2735 P08151 GLI1 human T304 27708600 GEKPHKCtFEGCRKS X -PRKCI PKCI P41743 human BAD 572 Q92934 BAD human S75 447860 EIRsRHssyPAGtED Bcl-2_BAD X X 9291; 5284; 9296; 5193; 11865; 94223 -PRKCI PKCI P41743 human Vimentin 7431 P08670 VIM human S34 455454 srsyVttstrtysLG Filament_head X -PRKCI PKCI P41743 human KLF10 7071 Q13118 KLF10 human S384 5263526 GkTYFKssHLkAHTR X -PRKCI PKCI P41743 human Tau iso8 4137 P10636-8 MAPT human S258 487453 PDLkNVKskIGstEN Tubulin-binding X -PRKCI PKCI P41743 human EZH2 2146 Q15910 EZH2 human T487 452848 APAEDVDtPPRKKKR X -PRKCI PKCI P41743 human EZH2 2146 Q15910 EZH2 human S690 58924703 KIRFANHsVNPNCyA SET X -PRKCI PKCI P41743 human Cortactin 2017 Q14247 CTTN human S261 13879503 EKLQLHEsQkDyktG HS1_rep X X -PRKCI PKCI P41743 human P70S6KB 6199 Q9UBS0 RPS6KB2 human S473 450071 PPSGTKKsKRGRGRP X -PRKCI PKCI P41743 human BAD 572 Q92934 BAD human S118 447863 GRELRRMsDEFVDsF Bcl-2_BAD X X 9297 -PRKCI PKCI P41743 human YKT6 10652 O15498 YKT6 human S174 27456090 LDDLVsksEVLGtQS Synaptobrevin X -PRKCI PKCI P41743 human Vimentin 7431 P08670 VIM human S39 451766 ttstrtysLGsALrP Filament_head X 13614 -PRKCI PKCI P41743 human Fe65 11785 Q9QXJ1 Apbb1 mouse S459 13309858 VWGVGRDsGSNRDFA PID X -PRKCI PKCI P41743 human ROCK1 6093 Q13464 ROCK1 human S1341 1216639 tRstANQsFRKVVKN X X -PRKCI PKCI P41743 human AID 11628 Q9WVE0 Aicda mouse T140 6835300 GVQIGIMtFKDYFYC APOBEC2 X -PRKCI PKCI P41743 human GluR1 50592 P19490 Gria1 rat S836 467226 CYkSRSEskRMkGFC X -PRKCI PKCI P41743 human AMOT 154796 Q4VCS5 AMOT human S538 56589714 EDTRKtIsQLFAKNk X -PRKCI PKCI P41743 human p300 2033 Q09472 EP300 human S89 447592 SELLRSGsSPNLNMG X -PRKCI PKCI P41743 human PAR3-alpha 56288 Q8TEW0 PARD3 human S827 467266 REGFGRQsMSEKRtK X -PRKCI PKCI P41743 human KLF10 7071 Q13118 KLF10 human T445 20573500 FMRSDHLtkHARRHL zf-C2H2 X -PRKCI PKCI P41743 human EZH2 2146 Q15910 EZH2 human T345 4957354 LtAERIKtPPkRPGG X 45153 -PRKCI PKCI P41743 human NRF2 4780 Q16236 NFE2L2 human S40 450082 SREVFDFsQRRkEYE X -PRKCI PKCI P41743 human Vimentin 7431 P08670 VIM human S56 451514 srsLyAssPGGVyAt Filament_head X 3877; 7391 -Prkcg PKCG P63319 rat GluR4 29629 P19493 Gria4 rat S862 448810 TRNKARLsITGSVGE X -Prkcg PKCG P63319 rat NMDAR1 24408 P35439 Grin1 rat S890 447737 ITSTLAssFKRRRss X -Prkcg PKCG P63319 rat Kv3.1 25327 P25122 Kcnc1 rat S503 464642 LEINRADsKLNGEVA X -Prkcg PKCG P63319 rat DGKG 25666 P49620 Dgkg rat S779 471078 PQKSsFFsLRRKSRS X -Prkcg PKCG P63319 rat DGKG 25666 P49620 Dgkg rat S776 471077 MGPPQKSsFFsLRRK X -ZAP70 ZAP70 P43403 human LAT iso2 27040 O43561-2 LAT human Y226 448006 EEEGAPDyENLQELN LAT X X 54364; 45170 -ZAP70 ZAP70 P43403 human GAB2 9846 Q9UQC2 GAB2 human Y614 449788 KSTGsVDyLALDFQP X -ZAP70 ZAP70 P43403 human ZAP70 7535 P43403 ZAP70 human Y315 448867 MPMDtsVyEsPysDP X -ZAP70 ZAP70 P43403 human SHC1 iso2 6464 P29353-2 SHC1 human Y239 448509 EEPPDHQyyNDFPGK X X -ZAP70 ZAP70 P43403 human DBNL 28988 Q9UJU6 DBNL human Y334 450090 QAEEEAVyEEPPEQE X X -ZAP70 ZAP70 P43403 human AGO2 27161 Q9UKV8 AGO2 human Y529 17533104 LPGKtPVyAEVkRVG Piwi X -ZAP70 ZAP70 P43403 human P38A 26416 P47811 Mapk14 mouse Y323 455799 DEPVADPyDQSFESR X -ZAP70 ZAP70 P43403 human LAT iso2 27040 O43561-2 LAT human Y171 448004 SMESIDDyVNVPESG LAT X X -ZAP70 ZAP70 P43403 human PLCG1 25738 P10686 Plcg1 rat Y1253 448576 EGsFEARyQQPFEDF X -ZAP70 ZAP70 P43403 human LNK 16923 O09039 Sh2b3 mouse Y536 476934 LRAIDNQyTPLSQLC X -ZAP70 ZAP70 P43403 human ZAP70 7535 P43403 ZAP70 human Y319 447587 tsVyEsPysDPEELk X 2701; 2717; 14791; 73382; 82975; 31754 -ZAP70 ZAP70 P43403 human LAT iso2 27040 O43561-2 LAT human Y132 447760 DDyHNPGyLVVLPDS LAT X X -ZAP70 ZAP70 P43403 human SHC1 iso2 6464 P29353-2 SHC1 human Y240 448510 EPPDHQyyNDFPGKE X X -ZAP70 ZAP70 P43403 human DBNL 28988 Q9UJU6 DBNL human Y344 450091 PPEQETFyEQPPLVQ X X -ZAP70 ZAP70 P43403 human THEMIS 387357 Q8N1K5 THEMIS human Y429 27806312 EAALLPLyMEGGFVE CABIT X -ZAP70 ZAP70 P43403 human DUSP3 1845 P51452 DUSP3 human Y38 459626 NEVTPRIyVGNASVA DSPc X X -ZAP70 ZAP70 P43403 human THEMIS 387357 Q8N1K5 THEMIS human Y540 27806313 EEITEEQyyMMRRYE X X -ZAP70 ZAP70 P43403 human THEMIS 387357 Q8N1K5 THEMIS human Y95 27806315 IVADkTPyLTMEEIT CABIT X -ZAP70 ZAP70 P43403 human SLP76 3937 Q13094 LCP2 human Y128 448219 DGEDDGDyEsPNEEE X X -ZAP70 ZAP70 P43403 human SHC1 iso2 6464 P29353-2 SHC1 human Y317 448511 ELFDDPSyVNVQNLD X -ZAP70 ZAP70 P43403 human ZAP70 7535 P43403 ZAP70 human Y493 447505 LGADDsyytARsAGk PK_Tyr_Ser-Thr X X 2704 -ZAP70 ZAP70 P43403 human SLP76 3937 Q13094 LCP2 human Y145 448220 PVEDDADyEPPPSND X X 14770; 16796 -ZAP70 ZAP70 P43403 human LAT iso2 27040 O43561-2 LAT human Y191 448005 SLDGSREyVNVSQEL LAT X X 20172 -ZAP70 ZAP70 P43403 human PLCG1 25738 P10686 Plcg1 rat Y783 447667 EGRNPGFyVEANPMP X 2821; 14461; 14008; 25678; 88717 -ZAP70 ZAP70 P43403 human THEMIS 387357 Q8N1K5 THEMIS human Y541 27806310 EITEEQyyMMRRYES X X -ZAP70 ZAP70 P43403 human P38A 1432 Q16539 MAPK14 human Y323 455799 DEPVADPyDQsFESR X X -ZAP70 ZAP70 P43403 human ZAP70 7535 P43403 ZAP70 human Y598 464392 QRMRACyysLASkVE X -ZAP70 ZAP70 P43403 human ZAP70 7535 P43403 ZAP70 human Y492 447504 ALGADDsyytARsAG PK_Tyr_Ser-Thr X X -ZAP70 ZAP70 P43403 human THEMIS 387357 Q8N1K5 THEMIS human Y174 27806311 LsQEGEFyECEDERI CABIT X -ZAP70 ZAP70 P43403 human ZAP70 7535 P43403 ZAP70 human Y597 464391 EQRMRACyysLASkV X -ZAP70 ZAP70 P43403 human DUSP3 1845 P51452 DUSP3 human Y138 448718 SPTLVIAyLMMRQKM DSPc X X -ZAP70 ZAP70 P43403 human Tau iso8 4137 P10636-8 MAPT human Y29 4103318 DRKDQGGytMHQDQE X -ZAP70 ZAP70 P43403 human LAT iso2 27040 O43561-2 LAT human Y127 448003 ADEDEDDyHNPGyLV LAT X -ZAP70 ZAP70 P43403 human Tau iso8 4137 P10636-8 MAPT human Y197 464351 KsGDRsGyssPGsPG X X -ZAP70 ZAP70 P43403 human ZAP70 7535 P43403 ZAP70 human Y126 447589 RDAMVRDyVRQTWkL X -ZAP70 ZAP70 P43403 human ZAP70 7535 P43403 ZAP70 human Y292 447586 DtLNsDGytPEPARI X -ZAP70 ZAP70 P43403 human SLP76 3937 Q13094 LCP2 human Y113 448218 ssFEEDDyESPNDDQ X X -ZAP70 ZAP70 P43403 human THEMIS 387357 Q8N1K5 THEMIS human Y353 27806314 PREFPTAyDLEIAkS CABIT X -BCR Bcr P11274 human 14-3-3 theta 10971 P27348 YWHAQ human S232 456053 LTLWtsDsAGEECDA X -BCR Bcr P11274 human 14-3-3 zeta 7534 P63104 YWHAZ human T232 449846 LTLWtsDtQGDEAEA X -BCR Bcr P11274 human Afadin 4301 P55196 AFDN human T909 6208300 VVTVAENtADELARS X -GSK3A GSK3A A6QLB8 cow Tau iso8 4137 P10636-8 MAPT human T231 449079 KKVAVVRtPPKsPss X 20473; 71429 -GSK3A GSK3A A6QLB8 cow Tau iso2 4137 P10636-2 MAPT human S315 449082 PVVSGDTsPRHLsNV X 35834; 20194; 98523; 91600; 49562 -GSK3A GSK3A A6QLB8 cow Tau iso6 4137 P10636-6 MAPT human S346 449082 PVVSGDTsPRHLSNV X 35834; 20194; 98523; 91600; 49562 -GSK3A GSK3A A6QLB8 cow Tau iso5 4137 P10636-5 MAPT human S325 449104 RVQSKIGsLDNITHV Tubulin-binding X -GSK3A GSK3A A6QLB8 cow Tau iso6 4137 P10636-6 MAPT human T173 449079 KKVAVVRtPPKsPSS X 20473; 71429 -GSK3A GSK3A A6QLB8 cow Tau iso8 4137 P10636-8 MAPT human S396 449081 GAEIVyKsPVVsGDt X 9632 -GSK3A GSK3A A6QLB8 cow Tau iso5 4137 P10636-5 MAPT human T181 447932 KTPPAPKtPPsSGEP X 12885; 66224; 62672 -GSK3A GSK3A A6QLB8 cow Tau iso8 4137 P10636-8 MAPT human S404 449082 PVVsGDtsPRHLsNV X 35834; 20194; 98523; 91600; 49562 -GSK3A GSK3A A6QLB8 cow Tau iso5 4137 P10636-5 MAPT human S195 450221 PPKSGDRsGYssPGs X -GSK3A GSK3A A6QLB8 cow Tau iso5 4137 P10636-5 MAPT human S262 447930 NVKSKIGsTENLKHQ Tubulin-binding X -GSK3A GSK3A A6QLB8 cow Tau iso5 4137 P10636-5 MAPT human T231 449079 KKVAVVRtPPKsPSS X 20473; 71429 -GSK3A GSK3A A6QLB8 cow Tau iso5 4137 P10636-5 MAPT human S198 449551 SGDRsGYssPGsPGt X -GSK3A GSK3A A6QLB8 cow Tau iso5 4137 P10636-5 MAPT human S365 449081 GAEIVYKsPVVsGDT X 9632 -GSK3A GSK3A A6QLB8 cow Tau iso2 4137 P10636-2 MAPT human S307 449081 GAEIVYKsPVVSGDT X 9632 -GSK3A GSK3A A6QLB8 cow Tau iso5 4137 P10636-5 MAPT human S369 449130 VYKsPVVsGDTsPRH X 35834; 20194; 98523; 91600; 49562 -GSK3A GSK3A A6QLB8 cow Tau iso5 4137 P10636-5 MAPT human T205 447933 ssPGsPGtPGSRSRT X 25377; 43964; 53001; 49561; 20060; 33032; 30505; 20739; 98160 -GSK3A GSK3A A6QLB8 cow Tau iso5 4137 P10636-5 MAPT human S184 452062 PAPKtPPsSGEPPKS X -GSK3A GSK3A A6QLB8 cow Tau iso5 4137 P10636-5 MAPT human S373 449082 PVVsGDTsPRHLSNV X 35834; 20194; 98523; 91600; 49562 -GSK3A GSK3A A6QLB8 cow Tau iso6 4137 P10636-6 MAPT human S338 449081 GAEIVYKsPVVSGDT X 9632 -GSK3A GSK3A A6QLB8 cow Tau iso6 4137 P10636-6 MAPT human S177 449080 VVRtPPKsPSSAKSR X 20473 -GSK3A GSK3A A6QLB8 cow Tau iso5 4137 P10636-5 MAPT human S202 447928 sGYssPGsPGtPGSR X 39357; 30505 -GSK3A GSK3A A6QLB8 cow Tau iso5 4137 P10636-5 MAPT human S199 447927 GDRsGYssPGsPGtP X 29957 -GSK3A GSK3A A6QLB8 cow Tau iso5 4137 P10636-5 MAPT human S235 449080 VVRtPPKsPSSAKSR X 20473 -GSK3A GSK3A A6QLB8 cow Tau iso8 4137 P10636-8 MAPT human S235 449080 VVRtPPKsPssAKsR X 20473 -PKMYT1 Myt1 Q99640 human CDK1 54237 P39951 Cdk1 rat Y15 447610 EKIGEGtyGVVyKGR Pkinase X 4539; 9111; 14566; 77897 -PKMYT1 Myt1 Q99640 human CDK1 983 P06493 CDK1 human T14 447608 IEkIGEGtyGVVykG Pkinase X X 2543 -PKMYT1 Myt1 Q99640 human CDK1 983 P06493 CDK1 human Y15 447610 EkIGEGtyGVVykGR Pkinase X X 4539; 9111; 14566; 77897 -NEK7 NEK7 Q8TDX7 human KIF14 9928 Q15058 KIF14 human S1220 114810404 NLHSsHssGLMDkSS X -NEK7 NEK7 Q8TDX7 human KIF14 9928 Q15058 KIF14 human S607 114810406 NLIDLAGsERCSTAH Kinesin X -NEK7 NEK7 Q8TDX7 human KIF11 3832 P52732 KIF11 human S1033 20798600 GINtLERskVEETTE Microtub_bind X -NEK7 NEK7 Q8TDX7 human KIF14 9928 Q15058 KIF14 human S1219 114810407 KNLHSsHssGLMDkS X -NEK7 NEK7 Q8TDX7 human KIF14 9928 Q15058 KIF14 human S56 31882103 NDDPLLRsAGKVRDI X -NEK7 NEK7 Q8TDX7 human TRF1 7013 P54274 TERF1 human S114 63083903 AIIHGLSsLTACQLR TRF X -NEK7 NEK7 Q8TDX7 human KIF14 9928 Q15058 KIF14 human S1217 114810405 PIKNLHSsHssGLMD X -Stk3 MST2 O54748 rat MST2 65189 O54748 Stk3 rat T180 448899 DTMAKRNtVIGTPFW Pkinase X 3681; 49332 -MAP2K2 MEK2 Q90891 chicken BMAL1 374115 Q9I8T7 BMAL1 chicken T534 448633 SPLNITStPPPDTSS X X -Lrrk1 LRRK1 Q3UHC2 mouse Rab7 19349 P51150 Rab7a mouse S72 468547 AGQERFQsLGVAFYR Ras X -GAK GAK O14976 human p63 8626 Q9H3D4 TP63 human T46 912008301 TMSQsTQtNEFLsPE X -GAK GAK O14976 human CLTC 1213 Q00610 CLTC human T606 1868832801 ILGNQMFtHYDRAHI Clathrin X X -GAK GAK O14976 human p63 8626 Q9H3D4 TP63 human T281 912008300 QYVEDPItGRQSVLV P53 X -DYRK3 DYRK3 O43781 human H3F3A 3020 P84243 H3-3A human T45 18545304 PHryrPGtVALrEIR Histone X -DYRK3 DYRK3 O43781 human PRAS40 84335 Q96B36 AKT1S1 human T246 470067 LPRPRLNtsDFQkLK PRAS X X 2640; 2997; 32263; 13175; 60202 -DYRK3 DYRK3 O43781 human SIRT1 93759 Q923E4 Sirt1 mouse T522 6006905 HLSELPPtPLHIsED X X -DYRK3 DYRK3 O43781 human SRC-3 8202 Q9Y6Q9 NCOA3 human S1330 3217872 PAFGRVSsPPNAMMS DUF1518 X X -CSNK2A1 CK2A1 P68399 cow DARPP-32 360616 Q6J4I0 Ppp1r1b rat S45 465607 LFRVSEHssPEEESS DARPP-32 X -CSNK2A1 CK2A1 P68399 cow Tau iso8 4137 P10636-8 MAPT human T39 451639 HQDQEGDtDAGLkEs X -CSNK2A1 CK2A1 P68399 cow DARPP-32 282459 P07516 PPP1R1B cow S45 465607 LFRLsEHsSPEEEAS DARPP-32 X -CSNK2A1 CK2A1 P68399 cow NFL 281348 P02548 NEFL cow S473 450895 EAKDEPPsEGEAEEE X -CSNK2A1 CK2A1 P68399 cow DARPP-32 282459 P07516 PPP1R1B cow S42 465608 PAMLFRLsEHsSPEE DARPP-32 X -CSNK2A1 CK2A1 P68399 cow adrenodoxin 281157 P00257 FDX1 cow T129 455475 FEKLEAItDEENDML Fer2 X -CSNK2A1 CK2A1 P68399 cow PKAR2A 518399 P00515 PRKAR2A cow S77 456583 DAVADsEsEDEEDLD X -CSNK2A1 CK2A1 P68399 cow Calmodulin 24242 P0DP29 Calm3 rat T118 469586 TNLGEkLtDEEVDEM EF-hand_7 X -CSNK2A1 CK2A1 P68399 cow Calmodulin 24242 P0DP29 Calm3 rat S102 448706 kDGNGyIsAAELRHV EF-hand_7 X -CSNK2A1 CK2A1 P68399 cow PKAR2A 518399 P00515 PRKAR2A cow S75 4702645 VADAVADsEsEDEED X -CSNK2A1 CK2A1 P68399 cow SYT1 281511 P48018 SYT1 cow T129 451522 DDAETGLtDGEEKEE X -CSNK2A1 CK2A1 P68399 cow Calmodulin 24242 P0DP29 Calm3 rat T80 448704 MARKMkDtDsEEEIR X -CSNK2A1 CK2A1 P68399 cow DARPP-32 282459 P07516 PPP1R1B cow S102 457675 NLGENQAsEEEDELG DARPP-32 X -CSNK2A1 CK2A1 P68399 cow Calmodulin 24242 P0DP29 Calm3 rat S82 448705 RKMkDtDsEEEIREA X -CSNK2A1 CK2A1 P68399 cow DARPP-32 360616 Q6J4I0 Ppp1r1b rat S102 457675 NLsENQAsEEEDELG DARPP-32 X 3401 -CSNK2A1 CK2A1 P68399 cow VDR 7421 P11473 VDR human S208 456982 SFSNLDLsEEDSDDP X -TXK TXK P42681 human TXK 7294 P42681 TXK human Y420 460526 RYVLDDEyVSSFGAK PK_Tyr_Ser-Thr X -TXK TXK P42681 human TXK 7294 P42681 TXK human Y91 2861416 KIQVKALyDFLPREP SH3_1 X -BMPR1B BMPR1B O00238 human SMAD1 4086 Q15797 SMAD1 human S465 448363 HNPIssVs_______ X X 9516; 9576; 12428; 11971; 67959; 13820; 85553; 52937 -BMPR1B BMPR1B O00238 human SMAD2 4087 Q15796 SMAD2 human S467 447495 sVRCssMs_______ X 3108; 8828; 11979; 26945; 55041; 68550; 18338; 56532; 67804 -BMPR1B BMPR1B O00238 human SMAD1 4086 Q15797 SMAD1 human S462 448361 GsPHNPIssVs____ X X -BMPR1B BMPR1B O00238 human SMAD2 4087 Q15796 SMAD2 human S465 447494 sPsVRCssMs_____ X 3108; 8828; 11979; 26945; 55041; 68550; 18338; 56532; 67804 -BMPR1B BMPR1B O00238 human SMAD1 4086 Q15797 SMAD1 human S463 448362 sPHNPIssVs_____ X X 9516; 9576; 12428; 11971; 67959; 13820; 85553; 52937 -BMPR1B BMPR1B O00238 human SMAD2 4087 Q15796 SMAD2 human S464 447567 GsPsVRCssMs____ X -Prkce PKCE P16054 mouse PRKD1 18760 Q62101 Prkd1 mouse S744 448589 ARIIGEksFRRsVVG Pkinase X X 2054 -Prkce PKCE P16054 mouse PRKD1 85421 Q9WTQ1 Prkd1 rat S748 448590 GEKsFRRsVVGTPAY Pkinase X -Prkce PKCE P16054 mouse Akt1 24185 P47196 Akt1 rat S473 447855 RPHFPQFsYSASGTA Pkinase_C X 9271; 3787; 4060; 4051; 5102; 4058; 2336; 2337; 4075; 4070; 5012; 4071; 92982; 5315; 9563; 9018; 12694; 52240; 11962; 15116; 88106; 26580; 68035; 31957; 23430; 20235 -Prkce PKCE P16054 mouse RIP140 268903 Q8CBD1 Nrip1 mouse S102 3345202 AAKRKRLsDsIVNLN NRIP1_repr_1 X -Prkce PKCE P16054 mouse FBXW7 55294 Q969H0 FBXW7 human S10 17337000 QELLSVGsKRRRTGG X -Prkce PKCE P16054 mouse FBXW7 55294 Q969H0 FBXW7 human S18 17337001 KRRRTGGsLRGNPSs X -Prkce PKCE P16054 mouse TNNI3 21954 P48787 Tnni3 mouse S24 448424 APVRRRssANyRAYA Troponin-I_N X -Prkce PKCE P16054 mouse PKCD 170538 P09215 Prkcd rat T505 447511 FGENRAstFCGTPDy Pkinase X 9379; 9374; 2060; 38938; 93292 -Prkce PKCE P16054 mouse STAT3 20848 P42227 Stat3 mouse S727 448191 NtIDLPMsPRTLDSL X X 9134; 9136; 34911; 94994; 49081; 58978; 87544; 71958; 50804 -Prkce PKCE P16054 mouse NSF 18195 P46460 Nsf mouse S460 15794301 MNRHIKAstkVEVDM AAA_lid_3 X -Prkce PKCE P16054 mouse PRKD1 18760 Q62101 Prkd1 mouse S748 448590 GEksFRRsVVGtPAy Pkinase X X 2054 -Prkce PKCE P16054 mouse RIP140 268903 Q8CBD1 Nrip1 mouse S1003 455634 VTDHRTFsYPGMVKT NRIP1_repr_4 X -Prkce PKCE P16054 mouse ITGB1 16412 P09055 Itgb1 mouse T788 448600 PIyksAVttVVNPky Integrin_b_cyt X -Prkce PKCE P16054 mouse PRKD1 85421 Q9WTQ1 Prkd1 rat S744 448589 ARIIGEKsFRRsVVG Pkinase X -Prkce PKCE P16054 mouse TRAF2 22030 P39429 Traf2 mouse T117 471341 DGCTWKGtLKEYESC X X -Prkce PKCE P16054 mouse TNNI3 21954 P48787 Tnni3 mouse S23 448423 PAPVRRRssANyRAY Troponin-I_N X -Prkce PKCE P16054 mouse ITGB1 16412 P09055 Itgb1 mouse T789 447709 IyksAVttVVNPkyE Integrin_b_cyt X -Prkce PKCE P16054 mouse MYBPC3 17868 O70468 Mybpc3 mouse S302 471081 sLLKKRDsFRRDskL X X -Prkce PKCE P16054 mouse GABRG2 14406 P22723 Gabrg2 mouse S365 486436 FVSNRkPskDkDkkk Neur_chan_memb X -Prkce PKCE P16054 mouse Akt1 24185 P47196 Akt1 rat T308 447856 KDGATMKtFCGTPEy Pkinase X 5106; 2965; 9275; 4056; 5056; 13842; 13038; 43506; 48646; 86758; 80722; 77440; 80556 -Prkce PKCE P16054 mouse MYBPC3 17868 O70468 Mybpc3 mouse S273 471079 RsAFRRtsLAGAGRR X X -Pik3cd PIK3CD O35904 mouse Btk 12229 P35991 Btk mouse Y551 447486 RYVLDDEyTsSVGSK PK_Tyr_Ser-Thr X 69360; 18805; 64137; 16803 -Pik3cd PIK3CD O35904 mouse Btk 12229 P35991 Btk mouse Y223 447485 LKKVVALyDyMPMNA SH3_1 X 5082; 87141; 87457 -TYK2 Tyk2 P29597 human Tyk2 7297 P29597 TYK2 human Y292 450907 QAEGEPCyIRDSGVA Jak1_Phl X -TYK2 Tyk2 P29597 human GJA1 24392 P08050 Gja1 rat Y313 454254 sEQNWANysAEQNRM Connexin43 X -TYK2 Tyk2 P29597 human GJA1 24392 P08050 Gja1 rat Y265 447815 kDCGsPkyAyFNGCS X X -TYK2 Tyk2 P29597 human KLF10 21847 O89091 Klf10 mouse Y179 18958500 KAASILNyQDNSFRR X -TYK2 Tyk2 P29597 human Tyk2 7297 P29597 TYK2 human Y1054 447499 AVPEGHEyyRVREDG PK_Tyr_Ser-Thr X 9321; 68790; 32901 -TYK2 Tyk2 P29597 human LATS1 16798 Q8BYR2 Lats1 mouse Y200 1876860400 SLGENVVyRSEsPNs X X -TYK2 Tyk2 P29597 human Tyk2 7297 P29597 TYK2 human Y1055 447503 VPEGHEyyRVREDGD PK_Tyr_Ser-Thr X 9321; 68790; 32901 -TYK2 Tyk2 P29597 human Siva 10572 O15304 SIVA1 human Y53 15329000 LFLGAQAyLDHVWDE Siva X -TYK2 Tyk2 P29597 human IFNAR1 3454 P17181 IFNAR1 human Y466 450029 VFLRCINyVFFPSLK X -TYK2 Tyk2 P29597 human RACK1 10399 P63244 RACK1 human Y194 452182 NHIGHtGyLNTVTVS WD40 X -TYK2 Tyk2 P29597 human GJA1 24392 P08050 Gja1 rat Y267 465295 CGsPkyAyFNGCSSP X -TYK2 Tyk2 P29597 human IFNAR1 3454 P17181 IFNAR1 human Y481 2091900 PSSSIDEyFSEQPLK X -TYK2 Tyk2 P29597 human Siva 10572 O15304 SIVA1 human Y162 15329001 LVDCSDMyEKVLCTS Siva X -TYK2 Tyk2 P29597 human STAT3 6774 P40763 STAT3 human Y640 386186603 QIQsVEPytkQQLNN SH2 X -TYK2 Tyk2 P29597 human GJA1 24392 P08050 Gja1 rat Y247 447814 VKGRsDPyHATTGPL X X -TYK2 Tyk2 P29597 human LATS1 16798 Q8BYR2 Lats1 mouse Y277 484657 PSSQTKRysGNMEYV X X -TYK2 Tyk2 P29597 human STAT1 6772 P42224 STAT1 human Y701 447754 DGPkGtGyIktELIs X X 9174; 9167; 5375; 25685; 8062; 8183; 8009; 55603; 7649; 25809; 57216; 45118; 39205; 88845; 88211; 76285; 90145 -PTK2B Pyk2 Q14289 human Hic-5 7041 O43294 TGFB1I1 human Y60 450964 SGDKDHLystVCKPR Paxillin X -PTK2B Pyk2 Q14289 human ID3 3399 Q02535 ID3 human Y48 35524904 LDDMNHCySRLRELV HLH X X -PTK2B Pyk2 Q14289 human Cortactin 2017 Q14247 CTTN human Y470 447703 AyATEAVyESAEAPG X X -PTK2B Pyk2 Q14289 human ID3 3399 Q02535 ID3 human S18 25295708 yEAVCCLsERsLAIA X -PTK2B Pyk2 Q14289 human ID3 3399 Q02535 ID3 human S5 451011 ___MkALsPVRGCyE X X -PTK2B Pyk2 Q14289 human NPHP1 4867 O15259 NPHP1 human Y46 18449508 PNKRQHIyQRCIQLK X -PTK2B Pyk2 Q14289 human eNOS 397557 Q7YSG7 NOS3 pig Y659 2811400 FGLGSRAyPHFCAFA Flavodoxin_1 X -PTK2B Pyk2 Q14289 human DDEF1 13196 Q9QWY8 Asap1 mouse Y308 450437 PKEVGGLyVASRANS X -PTK2B Pyk2 Q14289 human LAT iso2 27040 O43561-2 LAT human Y171 448004 SMESIDDyVNVPESG LAT X -PTK2B Pyk2 Q14289 human eNOS 18127 P70313 Nos3 mouse Y656 2811400 FGLGSRAyPHFCAFA Flavodoxin_1 X -PTK2B Pyk2 Q14289 human SNCA 6622 P37840 SNCA human Y125 448279 VDPDNEAyEMPsEEG Synuclein X -PTK2B Pyk2 Q14289 human FAK 5747 Q05397 PTK2 human Y407 447888 IIDEEDtytMPSTRD X -PTK2B Pyk2 Q14289 human DDEF1 13196 Q9QWY8 Asap1 mouse Y782 450438 RDKQRLSyGAFTNQI X -PTK2B Pyk2 Q14289 human eNOS 4846 P29474 NOS3 human Y657 2811400 FGLGSRAyPHFCAFA Flavodoxin_1 X -PTK2B Pyk2 Q14289 human NPHP1 4867 O15259 NPHP1 human Y349 18449510 GNQFRANyFLQPELM X -PTK2B Pyk2 Q14289 human ATG3 67841 Q9CPX6 Atg3 mouse Y203 62940500 QTRTYDLyITYDkYY Autophagy_act_C X -PTK2B Pyk2 Q14289 human Cortactin 2017 Q14247 CTTN human Y486 447704 yPAEDStyDEYENDL X X -PTK2B Pyk2 Q14289 human ID3 3399 Q02535 ID3 human Y11 15411043 LsPVRGCyEAVCCLs X X -PTK2B Pyk2 Q14289 human Cortactin 2017 Q14247 CTTN human Y421 447702 rLPssPVyEDAAsFK X X 4569 -PTK2B Pyk2 Q14289 human Pyk2 19229 Q9QVP9 Ptk2b mouse Y402 447955 CSIESDIyAEIPDET X 3291 -PTK2B Pyk2 Q14289 human Pyk2 2185 Q14289 PTK2B human Y402 447955 CsIEsDIyAEIPDEt X 3291 -PTK2B Pyk2 Q14289 human STIM1 6786 Q13586 STIM1 human Y361 25755095 THEVEVQyYNIKKQN SOAR X -RPS6KB2 P70S6KB Q9UBS0 human EEF2K 29904 O00418 EEF2K human S366 447827 sPQVRtLsGSRPPLL X 3691 -RPS6KB2 P70S6KB Q9UBS0 human HSP27 3315 P04792 HSPB1 human S82 448403 RALsRQLssGVsEIr X 2406; 2401; 9709; 11892; 64293 -RPS6KB2 P70S6KB Q9UBS0 human TRBP 6895 Q15633 TARBP2 human S283 27457469 ILSLRsCsLGsLGAL X -RPS6KB2 P70S6KB Q9UBS0 human HSP27 3315 P04792 HSPB1 human S78 448402 PAysRALsRQLssGV X 2405 -RPS6KB2 P70S6KB Q9UBS0 human GSK3B 2932 P49841 GSK3B human S9 449111 SGRPRttsFAEsCkP X 9336; 9331; 9327; 9323; 9322; 9325; 5558; 8566; 79774; 8466; 25462; 14026; 14332; 14310; 14630 -RPS6KB2 P70S6KB Q9UBS0 human K18 3875 P05783 KRT18 human S53 447734 IsVsrstsFrGGMGs X -RPS6KB2 P70S6KB Q9UBS0 human hnRNP A1 3178 P09651 HNRNPA1 human S4 468002 ____MsksEsPkEPE X X -RPS6KB2 P70S6KB Q9UBS0 human hnRNP A1 3178 P09651 HNRNPA1 human S6 455946 __MsksEsPkEPEQL X X -RPS6KB2 P70S6KB Q9UBS0 human RICTOR 253260 Q6R327 RICTOR human T1135 458276 NRRIRtLtEPsVDFN RICTOR_phospho X 3806 -FGR FGR P09769 human FAK 5747 Q05397 PTK2 human Y925 447966 DRsNDkVyENVtGLV Focal_AT X 3284 -FGR FGR P09769 human ACO2 79250 Q9ER34 Aco2 rat Y544 1458607 FDPGQDTyQHPPkDS X -FGR FGR P09769 human 5-LO 240 P09917 ALOX5 human Y446 33670311 RAMKDLtyAsLCFPE Lipoxygenase X -FGR FGR P09769 human TBK1 29110 Q9UHD2 TBK1 human Y354 3437786 SSNQELIyEGRRLVL TBK1_ULD X -FGR FGR P09769 human GLO1 2739 Q04760 GLO1 human Y136 463450 GIAVPDVysACkRFE Glyoxalase X -FGR FGR P09769 human SDHA Q920L2 Sdha rat Y596 1458603 YkVRIDEyDYSkPIE Succ_DH_flav_C X -FGR FGR P09769 human SDHA Q920L2 Sdha rat Y535 1458604 CEkVSQLyGDLQHLk Succ_DH_flav_C X -FGR FGR P09769 human NRF2 4780 Q16236 NFE2L2 human Y576 460703 RDEDGkPysPSEYSL X -FGR FGR P09769 human FAK 5747 Q05397 PTK2 human Y397 447887 sVsEtDDyAEIIDEE X 3283; 8556 -FGR FGR P09769 human RIPK2 8767 O43353 RIPK2 human Y474 4270705 DLIMKEDyELVSTkP CARD X X -FGR FGR P09769 human 5-LO 240 P09917 ALOX5 human Y54 33670310 ERGAVDSyDVTVDEE PLAT X -FGR FGR P09769 human FAK 5747 Q05397 PTK2 human Y576 447889 RyMEDstyyKAsKGK PK_Tyr_Ser-Thr X 3281 -FGR FGR P09769 human TBK1 29110 Q9UHD2 TBK1 human Y394 126839800 LNTIGLIyEkISLPk TBK1_ULD X -FGR FGR P09769 human 5-LO 240 P09917 ALOX5 human Y43 33670312 HLLDKPFyNDFERGA PLAT X -FGR FGR P09769 human ACO2 79250 Q9ER34 Aco2 rat Y665 1458606 VVIGDENyGEGsSRE Aconitase_C X -FGR FGR P09769 human IKKG 8517 Q9Y6K9 IKBKG human Y374 473650 PLPPAPAyLssPLAL X -FGR FGR P09769 human ACO2 79250 Q9ER34 Aco2 rat Y71 1458605 TLSEkIVyGHLDDPA Aconitase X -Uhmk1 KIS P97343 mouse STMN1 3925 P16949 STMN1 human S38 448556 sVPEFPLsPPkKkDL Stathmin X 3426; 4191 -Rps6ka1 p90RSK P18653 mouse TTP 22695 P22893 Zfp36 mouse S316 451153 LPIFNRIsVsE____ X X -Rps6ka1 p90RSK P18653 mouse C/EBP-beta 12608 P28033 Cebpb mouse T217 448447 AkAKAkktVDKLsDE X X -Rps6ka1 p90RSK P18653 mouse GAB2 14389 Q9Z1S8 Gab2 mouse S620 15410336 PsPHRKPstSsVtsD X -Rps6ka1 p90RSK P18653 mouse SRF 6722 P11831 SRF human S103 447692 RGLKRsLsEMEIGMV X 4261 -Rps6ka1 p90RSK P18653 mouse CASP8 12370 O89110 Casp8 mouse T265 21258500 KMKDRKGtDCDKEAL Peptidase_C14 X X -Rps6ka1 p90RSK P18653 mouse BAD 12015 Q61337 Bad mouse S112 447860 ETRsRHssyPAGtEE Bcl-2_BAD X X 9291; 5284; 9296; 5193; 11865; 94223 -Rps6ka1 p90RSK P18653 mouse LKB1 20869 Q9WTK7 Stk11 mouse S431 448147 sNKIRRLsACKQQ__ X X 3482 -Rps6ka1 p90RSK P18653 mouse TNNI3 21954 P48787 Tnni3 mouse S24 448424 APVRRRssANyRAYA Troponin-I_N X X -Rps6ka1 p90RSK P18653 mouse MITF iso8 17342 Q08874-8 Mitf mouse S409 450265 KTSSRRSsMSAEETE DUF3371 X -Rps6ka1 p90RSK P18653 mouse FLNA 192176 Q8BTM8 Flna mouse S2152 451357 TRRRRAPsVANIGsH Filamin X 4761 -Rps6ka1 p90RSK P18653 mouse BAD 12015 Q61337 Bad mouse S155 447863 GRELRRMsDEFEGsF Bcl-2_BAD X 9297 -Rps6ka1 p90RSK P18653 mouse ERK5 23939 Q9WVS8 Mapk7 mouse S496 455518 SRLRDGPsAPLEAPE X -Rps6ka1 p90RSK P18653 mouse GAB2 14389 Q9Z1S8 Gab2 mouse S160 448382 LLRERKSsAPSHSsQ X 3884 -Rps6ka1 p90RSK P18653 mouse K17 16667 Q9QWL7 Krt17 mouse S44 464291 AGsCRLGsASGLGSA X -Rps6ka1 p90RSK P18653 mouse H3 iso3 15081 P84244 H3f3b mouse S10 455676 tKQTARksTGGkAPR Histone X 9701; 9711; 9706; 3465; 3642; 3377; 3475; 3458; 5764; 47398; 8481; 8552; 53348; 29237; 66065; 43185; 64522; 52725 -Rps6ka1 p90RSK P18653 mouse TNNI3 21954 P48787 Tnni3 mouse S23 448423 PAPVRRRssANyRAY Troponin-I_N X X -Rps6ka1 p90RSK P18653 mouse MYBPC3 295929 P56741 Mybpc3 rat S288 471080 AGTGRRtsDSHEDAG X -Rps6ka1 p90RSK P18653 mouse HMGN1 15312 P18608 Hmgn1 mouse S7 465531 _MPKRKVsADGAAkA HMG14_17 X -Rps6ka1 p90RSK P18653 mouse CREB 12912 Q01147 Creb1 mouse S119 448228 EILsRRPsyRkILND pKID X 9187; 9196; 9198; 4095; 14228; 14001; 39561; 80120; 44864; 54960; 95995 -Rps6ka1 p90RSK P18653 mouse GAB2 14389 Q9Z1S8 Gab2 mouse S211 4825112 TENARSAsFSQGTRQ X -Stk26 MST4 Q99JT2 mouse TRAF6 22034 P70196 Traf6 mouse T494 34362608 LEALRQGtFIKDDTL X -Stk26 MST4 Q99JT2 mouse TRAF6 22034 P70196 Traf6 mouse T471 40240800 LLAFQRPtIPRNPKG X -Eif2ak1 HRI Q9Z2R9 mouse HRI 15467 Q9Z2R9 Eif2ak1 mouse T485 447595 GKGTRtHtSRVGtCL Pkinase X -Eif2ak1 HRI Q9Z2R9 mouse HRI 15467 Q9Z2R9 Eif2ak1 mouse T483 449629 RNGKGTRtHtSRVGt Pkinase X -Aurka AurA P97477 mouse KIFAP3 16579 P70188 Kifap3 mouse S102 18260847 YLQNRRDsLPGKEKK KAP X -Aurka AurA P97477 mouse AurA 6790 O14965 AURKA human T288 448784 APSsRRttLCGtLDy Pkinase X 3079; 2914; 13464; 8525 -Aurka AurA P97477 mouse CDC25B 12531 P30306 Cdc25b mouse S351 452008 VQSKRRKsVtPLEEQ M-inducer_phosp X -Aurka AurA P97477 mouse CPEB 12877 P70166 Cpeb1 mouse T171 449610 VRGSRLDtRPILDsR CEBP1_N X X -Aurka AurA P97477 mouse PLK1 18817 Q07832 Plk1 mouse T210 448139 YEGERKKtLCGtPNY Pkinase X 4354; 5472 -Prkaa1 AMPKA1 P54645 rat p27Kip1 12576 P46414 Cdkn1b mouse T170 6058800 QNkRANRtEENVsDG X -Prkaa1 AMPKA1 P54645 rat AMPKB1 83803 P80386 Prkab1 rat S24 448111 HKTPRRDssGGTKDG X -Prkaa1 AMPKA1 P54645 rat ACC1 60581 P11497 Acaca rat S1215 449868 YGMTHVAsVSDVLLD ACC_central X -Prkaa1 AMPKA1 P54645 rat AMPKB1 83803 P80386 Prkab1 rat S96 450436 KEVYLSGsFNNWsKL AMPK1_CBM X -Prkaa1 AMPKA1 P54645 rat p27Kip1 12576 P46414 Cdkn1b mouse S83 451426 WQEVERGsLPEFyYR X -Prkaa1 AMPKA1 P54645 rat TNNI3 29248 P23693 Tnni3 rat S151 451822 tLRRVRIsADAMMQA Troponin X -Prkaa1 AMPKA1 P54645 rat AMPKA1 65248 P54645 Prkaa1 rat T183 448786 SDGEFLRtsCGSPNY Pkinase X X 2535; 2531; 4188; 5256; 50081; 74281 -Prkaa1 AMPKA1 P54645 rat SQSTM1 113894 O08623 Sqstm1 rat S293 31872178 SSCSSEVsKPDGAGE X -Prkaa1 AMPKA1 P54645 rat ACC1 60581 P11497 Acaca rat S79 448292 FHMRSsMsGLHLVKQ X X 3661; 11818; 42801 -Prkaa1 AMPKA1 P54645 rat HNF4 alpha 3172 P41235 HNF4A human S313 449926 GkIkRLRsQVQVsLE Hormone_recep X -Prkaa1 AMPKA1 P54645 rat AMPKB1 83803 P80386 Prkab1 rat S25 448112 KTPRRDssGGTKDGD X -Prkaa1 AMPKA1 P54645 rat eNOS 24600 Q62600 Nos3 rat S1176 447884 TSRIRtQsFsLQERQ X X 9570 -Prkaa1 AMPKA1 P54645 rat AMPKA1 65248 P54645 Prkaa1 rat S496 450431 AtPQRSGsISNYRSC AdenylateSensor X 4185; 4184; 2537 -Prkaa1 AMPKA1 P54645 rat DRP1 114114 O35303 Dnm1l rat S656 483971 VPVARKLsAREQRDC X 4867; 6319 -Prkaa1 AMPKA1 P54645 rat PFKFB3 5209 Q16875 PFKFB3 human S461 448801 NPLMRRNsVtPLAsP X -Prkaa1 AMPKA1 P54645 rat NKCC1 6558 P55011 SLC12A2 human S77 3192079 RPLGPtPsQsRFQVD X -Prkaa1 AMPKA1 P54645 rat PFKFB2 24640 Q9JJH5 Pfkfb2 rat S469 448460 PVRMRRNsFtPLSSS X X -Prkaa1 AMPKA1 P54645 rat AMPKA1 65248 P54645 Prkaa1 rat T269 450433 VDPMKRAtIKDIREH Pkinase X -Prkaa1 AMPKA1 P54645 rat ACC1 60581 P11497 Acaca rat S1200 448290 IPtLNRMsFASNLNH ACC_central X -Prkaa1 AMPKA1 P54645 rat AMPKB1 83803 P80386 Prkab1 rat S182 448110 DVSELSssPPGPYHQ X 4186 -Prkaa1 AMPKA1 P54645 rat AMPKB1 83803 P80386 Prkab1 rat S101 450435 SGsFNNWsKLPLTRs AMPK1_CBM X -Prkaa1 AMPKA1 P54645 rat TORC2 74343 Q3U182 Crtc2 mouse S171 454622 sALNRtSsDsALHTs TORC_M X -Prkaa1 AMPKA1 P54645 rat PDLIM5 56376 Q8CI51 Pdlim5 mouse S177 38546304 TPLHLSAsGLHVSAN X -Prkaa1 AMPKA1 P54645 rat Claudin-4 304407 Q5XIT8 Cldn4 rat S199 15425616 KPYsAKYsAARsVPA X X -Prkaa1 AMPKA1 P54645 rat IRS1 16367 P35569 Irs1 mouse S789 447557 QHLRLSSsSGRLRYT X 2389 -Prkaa1 AMPKA1 P54645 rat MDM4 4194 O15151 MDM4 human S342 470031 SkLTHSLsTSDITAI X -Prkaa1 AMPKA1 P54645 rat eNOS 24600 Q62600 Nos3 rat T494 447885 TGITRKKtFKEVANA X X -Prkaa1 AMPKA1 P54645 rat p27Kip1 12576 P46414 Cdkn1b mouse T197 448781 KPGLRRQt_______ X -Prkaa1 AMPKA1 P54645 rat AMPKB1 83803 P80386 Prkab1 rat S108 448522 sKLPLTRsQNNFVAI AMPK1_CBM X 23021 -Prkaa1 AMPKA1 P54645 rat GYS1 100008660 P13834 GYS1 rabbit S8 449898 MPLSRTLsVSsLPGL X -Pak2 PAK2 Q8CIN4 mouse Myc 17869 P01108 Myc mouse S388 450961 RRNELKRsFFALRDQ HLH X X -Pak2 PAK2 Q8CIN4 mouse Myc 17869 P01108 Myc mouse T373 450960 EENDKRRtHNVLERQ HLH X X -Pak2 PAK2 Q8CIN4 mouse Myc 17869 P01108 Myc mouse T415 450962 VVILKKAtAYILSIQ HLH X X -PTK6 Brk Q13882 human CTNNB1 1499 P35222 CTNNB1 human Y142 449044 AVVNLINyQDDAELA X -PTK6 Brk Q13882 human ETV4 2118 P43268 ETV4 human Y392 5231710 KNRPAMNyDKLSRSL Ets X -PTK6 Brk Q13882 human STAP2 55620 Q9UGK3 STAP2 human Y250 478353 PFLLDEDyEKVLGyV X -PTK6 Brk Q13882 human CENTD2 116985 Q96P48 ARAP1 human Y231 3209592 PEFDDsDyDEVPEEG X -PTK6 Brk Q13882 human P130Cas 9564 P56945 BCAR1 human Y165 448722 PSPATDLyQVPPGPG X X 4015 -PTK6 Brk Q13882 human CTNNB1 1499 P35222 CTNNB1 human Y331 471405 LVNIMRTytyEkLLW X -PTK6 Brk Q13882 human PXN iso2 5829 P49023-2 PXN human Y118 448604 VGEEEHVysFPNKQK Paxillin X 2541; 69363 -PTK6 Brk Q13882 human CTNNB1 1499 P35222 CTNNB1 human Y64 12170302 VDTsQVLyEWEQGFS X -PTK6 Brk Q13882 human PXN iso2 5829 P49023-2 PXN human Y31 448785 FLSEETPySyPTGNH X -PTK6 Brk Q13882 human ARHGAP5 394 Q13017 ARHGAP5 human Y1109 455068 kGysDEIyVVPDDsQ RhoGAP_pG1_pG2 X X -PTK6 Brk Q13882 human Brk 5753 Q13882 PTK6 human Y447 450276 RLSSFtsyENPT___ X -PTK6 Brk Q13882 human KHDRBS1 20218 Q60749 Khdrbs1 mouse Y435 456717 ARPVkGAyREHPyGR X -PTK6 Brk Q13882 human Brk 5753 Q13882 PTK6 human Y342 450274 RLIKEDVyLsHDHNI PK_Tyr_Ser-Thr X -PTK6 Brk Q13882 human P130Cas 9564 P56945 BCAR1 human Y664 448399 EGGWMEDyDyVHLQG CAS_C X X -PTK6 Brk Q13882 human CTNNB1 1499 P35222 CTNNB1 human Y333 471406 NIMRTytyEkLLWTT X -PTK6 Brk Q13882 human KHDRBS1 20218 Q60749 Khdrbs1 mouse Y440 456716 GAyREHPyGRy____ X -PTK6 Brk Q13882 human Akt1 207 P31749 AKT1 human Y326 447858 EVLEDNDyGRAVDWW Pkinase X X -PTK6 Brk Q13882 human Akt1 207 P31749 AKT1 human Y315 448519 tFCGtPEyLAPEVLE Pkinase X X -PTK6 Brk Q13882 human STAT5B 6777 P51692 STAT5B human Y699 448198 tAkAVDGyVkPQIkQ X X 9365; 9356; 9359; 9351; 4322; 9314; 3939; 40284; 5387; 14603; 66740; 51879; 72712 -PTK6 Brk Q13882 human KHDRBS1 20218 Q60749 Khdrbs1 mouse Y443 456715 REHPyGRy_______ X -Mapk13 P38D Q9Z1B7 mouse DLG1 25252 Q62696 Dlg1 rat S122 3195032 VLPSERIsPQVPNEV MAGUK_N_PEST X -Mapk13 P38D Q9Z1B7 mouse DLG1 1739 Q12959 DLG1 human S122 3195032 tPPQEHIsPQItNEV MAGUK_N_PEST X -Mapk13 P38D Q9Z1B7 mouse DLG1 1739 Q12959 DLG1 human T209 35547401 VNTDSLEtPTYVNGT MAGUK_N_PEST X -Mapk13 P38D Q9Z1B7 mouse GYS1 2997 P13807 GYS1 human T84 1875332200 VELLEAPtPALkRTL Glycogen_syn X -Mapk13 P38D Q9Z1B7 mouse DLG1 25252 Q62696 Dlg1 rat T209 35547401 VNTDSLEtPTYVNGT MAGUK_N_PEST X -Mapk13 P38D Q9Z1B7 mouse GYS1 2997 P13807 GYS1 human S723 4787599 sssLStPsEPLsPts X -Mapk13 P38D Q9Z1B7 mouse DLG1 1739 Q12959 DLG1 human S158 2024309 FVsHsHIsPIKPTEA MAGUK_N_PEST X -Mapk13 P38D Q9Z1B7 mouse DLG1 25252 Q62696 Dlg1 rat S442 5931300 YLGQTPAsPARYsPI PDZ_assoc X -Mapk13 P38D Q9Z1B7 mouse DLG1 25252 Q62696 Dlg1 rat S447 15176604 PAsPARYsPISKAVL PDZ_assoc X -Mapk13 P38D Q9Z1B7 mouse DLG1 25252 Q62696 Dlg1 rat S158 2024309 FVSHSHIsPIKPTEA MAGUK_N_PEST X -Mapk13 P38D Q9Z1B7 mouse GYS1 2997 P13807 GYS1 human S727 457615 StPsEPLsPtssLGE X -Mapk13 P38D Q9Z1B7 mouse DLG1 25252 Q62696 Dlg1 rat S431 4749386 QSVDNHVsPSSYLGQ PDZ_assoc X -Mapk13 P38D Q9Z1B7 mouse GYS1 2997 P13807 GYS1 human T721 457616 AtsssLStPsEPLsP X -Mapk13 P38D Q9Z1B7 mouse GYS1 2997 P13807 GYS1 human T278 1875332700 kRkPDIVtPNGLNVk Glycogen_syn X -Chek1 Chk1 O35280 mouse H3 360198 P68433 H3c1 mouse T11 455680 kQTARkstGGkAPrk Histone X 9767; 9764 -ULK1 ULK1 O75385 human CDC37 11140 Q16543 CDC37 human S339 62877802 HMQRCIDsGLWVPNs CDC37_C X X -ULK1 ULK1 O75385 human ATG9A 79065 Q7Z3C6 ATG9A human S761 4722321 QsIPRsAsYPCAAPR X X -ULK1 ULK1 O75385 human AMPKA1 65248 P54645 Prkaa1 rat T368 25778000 FLDDHHLtRPHPERV X -ULK1 ULK1 O75385 human ULK1 22241 O70405 Ulk1 mouse S1047 10428800 RRLsALLsGVYA___ DUF3543 X X -ULK1 ULK1 O75385 human FBPase 2203 P09467 FBP1 human S88 55578725 LVMNMLKsSFATCVL FBPase X -ULK1 ULK1 O75385 human RIPK1 8737 Q13546 RIPK1 human T337 1868502604 ssRsNsAtEQPGSLH X -ULK1 ULK1 O75385 human MCR 4306 P08235 NR3C2 human S843 29669801 NEEKMHQsAMYELCQ Hormone_recep X X -ULK1 ULK1 O75385 human STX17 55014 P56962 STX17 human S289 4774791 MMEKLtSsCPDLPSQ X X -ULK1 ULK1 O75385 human AMPKB2 64562 Q9QZH4 Prkab2 rat T39 4739308 HKIMVGstDDPSVFS X -ULK1 ULK1 O75385 human RIPK1 8737 Q13546 RIPK1 human S296 56657827 YLsQLEEsVEEDVks X -ULK1 ULK1 O75385 human SMCR8 140775 Q8TEV9 SMCR8 human S400 31880997 PSQDRPPsSsLEECP X -ULK1 ULK1 O75385 human STING 340061 Q86WV6 STING1 human S366 31064700 QEPELLIsGMEkPLP X X 30495; 39887; 85735; 50907; 19781; 41622; 43499; 40818; 99309; 72650 -ULK1 ULK1 O75385 human BNIP3L 665 O60238 BNIP3L human S35 65958201 PPAGLNssWVELPMN BNIP3 X -ULK1 ULK1 O75385 human ATG13 9776 O75143 ATG13 human S355 21127300 DTETVSNssEGRAsP X X 26839; 46329 -ULK1 ULK1 O75385 human AMPKG1 25520 P80385 Prkag1 rat T262 25778003 NNLDVsVtKALQHRs X -ULK1 ULK1 O75385 human AMPKB2 64562 Q9QZH4 Prkab2 rat S38 3175295 EHKIMVGstDDPSVF X 82791 -ULK1 ULK1 O75385 human YAP1 10413 P46937 YAP1 human S227 1874514400 VQQNMMNsASGPLPD X X -ULK1 ULK1 O75385 human AMPKA1 65248 P54645 Prkaa1 rat S397 7445993 DELNPQKsKHQGVRK X -ULK1 ULK1 O75385 human ATG16L1 55054 Q676U5 ATG16L1 human S278 15425208 PAGGLLDsITNIFGR X X 45511; 84300 -ULK1 ULK1 O75385 human AMPKA1 65248 P54645 Prkaa1 rat S486 3195155 DEITEAKsGtAtPQR AdenylateSensor X -ULK1 ULK1 O75385 human SQSTM1 8878 Q13501 SQSTM1 human S349 14580829 sskEVDPstGELQsL X X 95697; 16177; 12074 -ULK1 ULK1 O75385 human ATG9A 79065 Q7Z3C6 ATG9A human S14 3203970 EyQRLEAsysDsPPG X X -ULK1 ULK1 O75385 human beclin 1 56208 O88597 Becn1 mouse S14 25268704 SSSTMQVsFVCQRCS X X 84966 -ULK1 ULK1 O75385 human RIPK1 8737 Q13546 RIPK1 human S335 209632700 VPssRsNsAtEQPGS X -ULK1 ULK1 O75385 human PFKM 5213 P08237 PFKM human S762 55569802 yEIDLDTsDHAHLEH X X -ULK1 ULK1 O75385 human beclin 1 8678 Q14457 BECN1 human S30 7446159 QPLkLDTsFkILDRV X X 54101; 35955 -ULK1 ULK1 O75385 human Raptor 57521 Q8N122 RPTOR human S792 2314600 DKMRRAssYSsLNSL X X 2083; 89146 -ULK1 ULK1 O75385 human Raptor 57521 Q8N122 RPTOR human S877 3205938 HIHQAGGsPPAssts X -ULK1 ULK1 O75385 human LDH-A 16828 P06151 Ldha mouse S196 1881982200 VLGEHGDsSVPVWSG X X -ULK1 ULK1 O75385 human AMPKB2 64562 Q9QZH4 Prkab2 rat S173 25778001 KLDSMESsETSCRDL X -ULK1 ULK1 O75385 human beclin 1 8678 Q14457 BECN1 human S337 41389909 LVPyGNHsYLESLTD APG6 X -ULK1 ULK1 O75385 human ENO1 2023 P06733 ENO1 human S282 22777189 QLADLyksFIkDyPV Enolase_C X X -ULK1 ULK1 O75385 human beclin 1 8678 Q14457 BECN1 human S96 472002 MstEsANsFTLIGEA X -ULK1 ULK1 O75385 human RB1CC1 9821 Q8TDY2 RB1CC1 human S986 31088112 ELQsLEQsHLkELED X -ULK1 ULK1 O75385 human RB1CC1 9821 Q8TDY2 RB1CC1 human S943 41389910 EMENIMHsQNCEIKE X -ULK1 ULK1 O75385 human SMCR8 140775 Q8TEV9 SMCR8 human S562 55469602 IRFQASIsPPELGET X -ULK1 ULK1 O75385 human PIKFYVE 18711 Q9Z1T6 Pikfyve mouse S327 4920349 MVPSYETsVsPQANR X -ULK1 ULK1 O75385 human syntenin 6386 O00560 SDCBP human S60 23150265 LsQyMGLsLNEEEIR Peptidase_M50 X -ULK1 ULK1 O75385 human ATG4B 23192 Q9Y4P1 ATG4B human S316 2527072 SIAELDPsIAVGFFC Peptidase_C54 X X -ULK1 ULK1 O75385 human SESN2 83667 P58004 SESN2 human S254 1869992400 NNsGGFEsARDVEAL PA26 X -ULK1 ULK1 O75385 human RAB9A 56382 Q9R0M6 Rab9a mouse S179 3191548 ILAtEDRsEHLIQTD X -ULK1 ULK1 O75385 human AMPKG1 25520 P80385 Prkag1 rat S269 25778004 tKALQHRsHYFEGVL CBS X -ULK1 ULK1 O75385 human ULK1 8408 O75385 ULK1 human S317 35495300 SHLASPPsLGEMQQL X 12753; 37762 -ULK1 ULK1 O75385 human RIPK1 8737 Q13546 RIPK1 human S291 1868502608 kFRPFYLsQLEEsVE X -ULK1 ULK1 O75385 human PIKFYVE 18711 Q9Z1T6 Pikfyve mouse S1548 4272931 DtsPRNIsPGLHNGE X -ULK1 ULK1 O75385 human syntenin 6386 O00560 SDCBP human S6 4148819 __MsLyPsLEDLkVD X -ULK1 ULK1 O75385 human HK1 3098 P19367 HK1 human S124 55569800 NIVHGSGsQLFDHVA Hexokinase_1 X X -ULK1 ULK1 O75385 human RIPK1 8737 Q13546 RIPK1 human S345 1868502606 EQPGSLHssQGLGMG X -ULK1 ULK1 O75385 human BNIP3 664 Q12983 BNIP3 human S17 27421704 QEESLQGsWVELHFs BNIP3 X -ULK1 ULK1 O75385 human SESN2 83667 P58004 SESN2 human S73 1869992401 GLEALMSsGRVDNLA PA26 X -ULK1 ULK1 O75385 human AMBRA1 55626 Q9C0C7 AMBRA1 human S635 30963588 ssSRLELsSSAsPQE X -ULK1 ULK1 O75385 human SMCR8 140775 Q8TEV9 SMCR8 human S492 484907 SKsDsQAsLtVPLsP X -ULK1 ULK1 O75385 human DENND3 22898 A2RUS2 DENND3 human S490 23050193 ELAPRNSsLRLtDTA X X -ULK1 ULK1 O75385 human AMPKA1 65248 P54645 Prkaa1 rat S360 7320945 LATSPPDsFLDDHHL X -ULK1 ULK1 O75385 human FLCN 201163 Q8NFG4 FLCN human S406 35542208 CVRIIPYsSQYEEAY Folliculin_C X X -ULK1 ULK1 O75385 human AMBRA1 55626 Q9C0C7 AMBRA1 human S465 5735057 SQASVYTsATEGRGF X -ULK1 ULK1 O75385 human Raptor 57521 Q8N122 RPTOR human S855 3205935 QRVLDtssLtQsAPA X X -ULK1 ULK1 O75385 human Raptor 57521 Q8N122 RPTOR human S859 2024885 DtssLtQsAPAsPtN X X -ULK1 ULK1 O75385 human SQSTM1 8878 Q13501 SQSTM1 human S403 22264800 ESLSQMLsMGFsDEG UBA_5 X 39786 -ULK1 ULK1 O75385 human ATG13 51897 Q91YI1 Atg13 mouse S354 21127300 DTETVSNsSEGRAsP X X 26839; 46329 -ULK1 ULK1 O75385 human SEC23A 10484 Q15436 SEC23A human S207 89117912 LQEMLGLskVPLTQA Sec23_trunk X X -ULK1 ULK1 O75385 human ATG13 9776 O75143 ATG13 human S389 41389905 INQVTLTsLDIPFAM X -ULK1 ULK1 O75385 human FBPase 2203 P09467 FBP1 human S63 55578726 HLyGIAGsTNVTGDQ FBPase X X -ULK1 ULK1 O75385 human AMPKB2 64562 Q9QZH4 Prkab2 rat S68 25778002 WQQDLDDsVKPTQQA X -ULK1 ULK1 O75385 human SQSTM1 18412 Q64337 Sqstm1 mouse S351 14580829 SsKEVDPsTGELQsL X X 95697; 16177; 12074 -ULK1 ULK1 O75385 human SMCR8 140775 Q8TEV9 SMCR8 human T666 55469603 ASRDISktsLDNYSD X -ULK1 ULK1 O75385 human PFKM 5213 P08237 PFKM human S74 55569803 EATWESVsMMLQLGG PFK X -ULK1 ULK1 O75385 human RIPK1 8737 Q13546 RIPK1 human S357 1868502603 GMGPVEEsWFAPSLE X X -ULK1 ULK1 O75385 human PARK2 5071 O60260 PRKN human S108 17550101 sLTRVDLsssVLPGD X X 36728 -ULK1 ULK1 O75385 human SQSTM1 18412 Q64337 Sqstm1 mouse S405 22264800 ESLSQMLsMGFsDEG UBA_5 X 39786 -ULK1 ULK1 O75385 human ATG101 60673 Q9BSB4 ATG101 human S203 41389907 ITDALGTsVTTTMRR X -ULK1 ULK1 O75385 human RIPK1 8737 Q13546 RIPK1 human S389 451866 ANyHLyGsRMDRQTK X -ULK1 ULK1 O75385 human SEC23B 10483 Q15437 SEC23B human S186 1394461700 SCEGISksYVFRGTk Sec23_trunk X X -ULK1 ULK1 O75385 human ENO1 2023 P06733 ENO1 human S115 55578724 ANAILGVsLAVCkAG Enolase_N X -ULK1 ULK1 O75385 human Raptor 57521 Q8N122 RPTOR human S863 453732 LtQsAPAsPtNkGVH X -ULK1 ULK1 O75385 human SQSTM1 18412 Q64337 Sqstm1 mouse S409 40253303 QMLsMGFsDEGGWLT UBA_5 X X -ULK1 ULK1 O75385 human PIKFYVE 18711 Q9Z1T6 Pikfyve mouse S710 1873645602 KILLLKCsIEYLYRE Cpn60_TCP1 X -ULK1 ULK1 O75385 human FLCN 201163 Q8NFG4 FLCN human S537 23107124 EDTQkLLsILGAsEE Folliculin_C X X -ULK1 ULK1 O75385 human FUNDC1 139341 Q8IVP5 FUNDC1 human S17 2025377 DyEsDDDsyEVLDLT X X -ULK1 ULK1 O75385 human FLCN 201163 Q8NFG4 FLCN human S542 23107127 LLsILGAsEEDNVKL Folliculin_C X X -ULK1 ULK1 O75385 human HK1 3098 P19367 HK1 human S364 55569801 TRLGVEPsDDDCVSV Hexokinase_2 X -ULK1 ULK1 O75385 human RIPK1 8737 Q13546 RIPK1 human S320 468644 AVVkRMQsLQLdCVA X 58274; 39341 -ULK1 ULK1 O75385 human RB1CC1 9821 Q8TDY2 RB1CC1 human S1323 41389911 EMQNVRTsLIAEQQT X -ULK1 ULK1 O75385 human RIPK1 8737 Q13546 RIPK1 human S333 4728178 VAVPssRsNsAtEQP X -ULK1 ULK1 O75385 human AMPKG1 25520 P80385 Prkag1 rat S260 15175992 TYNNLDVsVtKALQH X -ULK1 ULK1 O75385 human RIPK1 8737 Q13546 RIPK1 human S346 1868502607 QPGSLHssQGLGMGP X -ULK1 ULK1 O75385 human MAD1L1 8379 Q9Y6D9 MAD1L1 human S546 1868914507 RTKVLHMsLNPTsVA MAD X X -ULK1 ULK1 O75385 human beclin 1 8678 Q14457 BECN1 human S15 25268704 NNSTMQVsFVCQRCS X 84966 -ULK1 ULK1 O75385 human SEC16A 9919 O15027 SEC16A human S846 55578720 LAQPINFsVSLSNSH X -ULK1 ULK1 O75385 human ATG14 22863 Q6ZNE5 ATG14 human S29 4758494 LARDLVDsVDDAEGL X 13155; 92340 -ULK1 ULK1 O75385 human SEC23A 10484 Q15436 SEC23A human T405 18913536 FKMGFGGtLEIKTSR Sec23_BS X X -ULK1 ULK1 O75385 human ATG101 60673 Q9BSB4 ATG101 human S11 41389906 RSEVLEVsVEGRQVE ATG101 X 75959 -ULK1 ULK1 O75385 human AMPKA1 65248 P54645 Prkaa1 rat T488 3195167 ITEAKsGtAtPQRSG AdenylateSensor X -ULK1 ULK1 O75385 human PIKFYVE 18711 Q9Z1T6 Pikfyve mouse T309 5208531 RNRsAsItNLsLDRS X -ULK1 ULK1 O75385 human ULK1 22241 O70405 Ulk1 mouse T180 21041603 QSNMMAAtLCGSPMY Pkinase X X 50936; 88311 -ULK1 ULK1 O75385 human PIK3C3 5289 Q8NEB9 PIK3C3 human S249 35483209 ESsPILTsFELVKVP X X 13857 -ULK1 ULK1 O75385 human DENND3 22898 A2RUS2 DENND3 human S472 7997148 THRRMVVsMPNLQDI X X -ULK1 ULK1 O75385 human RIPK1 8737 Q13546 RIPK1 human S262 1868502605 YCPREIIsLMKLCWE PK_Tyr_Ser-Thr X -ULK1 ULK1 O75385 human beclin 1 8678 Q14457 BECN1 human S279 41389908 ATFHIWHsGQFGTIN APG6 X -ULK1 ULK1 O75385 human FLI 2314 Q13045 FLII human S64 1163832400 KLEHLSVsHNNLTTL LRR_8 X -BCKDK BCKDK O14874 human BCKDH E1-alpha 25244 P11960 Bckdha rat S333 449636 TYRIGHHstsDDSSA E1_dh X 40368 -BCKDK BCKDK O14874 human BCKDH E1-alpha 25244 P11960 Bckdha rat S343 451657 DDSSAyRsVDEVNYW E1_dh X -Srpk2 SRPK2 NP_001100045 rat RIMS1 84556 Q9JIR4 Rims1 rat S1078 4725320 RPDTSLHsPERERHS X -Srpk2 SRPK2 NP_001100045 rat RIMS1 84556 Q9JIR4 Rims1 rat S287 455664 KQASRSRsEPPRERK X -Srpk2 SRPK2 NP_001100045 rat RIMS1 84556 Q9JIR4 Rims1 rat S447 2761601 ARVsPPEsPRARAAA X -Srpk2 SRPK2 NP_001100045 rat RIMS1 84556 Q9JIR4 Rims1 rat S1045 4725312 PRAKRGRsAESLHMT X -Srpk2 SRPK2 NP_001100045 rat RIMS1 84556 Q9JIR4 Rims1 rat S1066 3926128 LDRARSAsTNCLRPD X -MAPK9 JNK2 iso2 P45984-2 human MFN2 9927 O95140 MFN2 human S27 25594503 HMAEVNAsPLkHFVT X X -MAPK9 JNK2 iso2 P45984-2 human STAT3 6774 P40763 STAT3 human S727 448191 NtIDLPMsPrTLDSL X X 9134; 9136; 34911; 94994; 49081; 58978; 87544; 71958; 50804 -TEC TEC P42680 human FGF2 14173 P15655 Fgf2 mouse Y81 13823202 KGVCANRyLAMKEDG FGF X X -TEC TEC P42680 human BDP1 26469 Q99952 PTPN18 human Y389 449000 sAEEAPLysKVtPRA X -TEC TEC P42680 human Etk 660 P51813 BMX human Y216 449835 SSTSLAQyDSNSKKI X -TEC TEC P42680 human FGF2 14173 P15655 Fgf2 mouse Y111 4942757 ERLESNNyNTYRSRK FGF X -TEC TEC P42680 human TEC 7006 P42680 TEC human Y206 449836 RLERGQEyLILEKND SH3_1 X -TEC TEC P42680 human FGF2 14173 P15655 Fgf2 mouse Y123 13823201 SRKYSSWyVALKRTG FGF X -TEC TEC P42680 human BDP1 26469 Q99952 PTPN18 human Y303 450260 LQNASPHyQNIKENC X -TEC TEC P42680 human Btk 695 Q06187 BTK human Y223 447485 LKKVVALyDyMPMNA SH3_1 X 5082; 87141; 87457 -TEC TEC P42680 human ITK 3702 Q08881 ITK human Y180 449834 ETVVIALyDyQtNDP SH3_1 X -TEC TEC P42680 human BDP1 26469 Q99952 PTPN18 human Y281 450259 AVQTEEQyRFLYHTV Y_phosphatase X -TEC TEC P42680 human FGF2 iso3 2247 P09038-2 FGF2 human Y82 13823202 KGVCANRyLAMKEDG FGF X -TEC TEC P42680 human BDP1 26469 Q99952 PTPN18 human Y354 450261 GHAMADTyAVVQKRG X -ALDOA ALDOA P00883 rabbit ALDOA 100009055 P00883 ALDOA rabbit H362 451798 ESLFISNhAY_____ Glycolytic X -STK19 G11 iso1 P49842-1 human NRas 4893 P01111 NRAS human S89 1867735502 FAINNSksFADINLY Ras X X -Mark1 MARK1 Q8VHJ5 mouse KIFAP3 16579 P70188 Kifap3 mouse S60 4711034 QKIIRLKsLNANtDI KAP X -PIK3C2A PIK3C2A O00443 human PKCI 5584 P41743 PRKCI human T564 2839109 tNEPVQLtPDDDDIV Pkinase_C X -PIK3C2A PIK3C2A O00443 human p70S6K 72508 Q8BSK8 Rps6kb1 mouse T412 448607 NQVFLGFtYVAPSVL Pkinase_C X 9206; 9234; 9205; 97596 -PIK3C2A PIK3C2A O00443 human SGK1 6446 O00141 SGK1 human T256 448431 EHNSTTStFCGTPEY Pkinase X -PIK3C2A PIK3C2A O00443 human Akt1 11651 P31750 Akt1 mouse S473 447855 RPHFPQFsysAsGtA Pkinase_C X 9271; 3787; 4060; 4051; 5102; 4058; 2336; 2337; 4075; 4070; 5012; 4071; 92982; 5315; 9563; 9018; 12694; 52240; 11962; 15116; 88106; 26580; 68035; 31957; 23430; 20235 -DDR1 DDR1 Q08345 human DDR1 780 Q08345 DDR1 human Y569 1869973810 PQNSVPHyAEADIVT X -DDR1 DDR1 Q08345 human DDR1 780 Q08345 DDR1 human Y586 1869973809 GVTGGNTyAVPALPP X -Mast4 MAST4 Q811L6 mouse ERM 104156 Q9CXC9 Etv5 mouse S367 451201 PPYQRRGsLQLWQFL X -EPHB6 EphB6 Q07497 chicken EphB6 418308 Q07497 EPHB6 chicken Y618 451264 yyIDPSTyEDPNEAI EphA2_TM X -EPHB6 EphB6 Q07497 chicken EphB6 418308 Q07497 EPHB6 chicken Y612 451263 RGLGVKyyIDPSTyE EphA2_TM X -EPHB6 EphB6 Q07497 chicken EphB6 418308 Q07497 EPHB6 chicken Y594 449769 SKRRETPyTDRLQQy EphA2_TM X -EPHB6 EphB6 Q07497 chicken EphB6 418308 Q07497 EPHB6 chicken Y611 461925 TRGLGVKyyIDPSTy EphA2_TM X -EPHB6 EphB6 Q07497 chicken EphB6 418308 Q07497 EPHB6 chicken Y796 449778 DDASNPTyTGALGCK PK_Tyr_Ser-Thr X -EPHB6 EphB6 Q07497 chicken EphB6 418308 Q07497 EPHB6 chicken Y601 461924 yTDRLQQyISTRGLG EphA2_TM X -Yes1 Yes Q04736 mouse Cortactin 13043 Q60598 Cttn mouse Y421 447702 RPPssPIyEDAAPFK X 4569 -Yes1 Yes Q04736 mouse PKCD 18753 P28867 Prkcd mouse Y332 450077 ILDNNGTyGKIWEGS X -Yes1 Yes Q04736 mouse PKCD 18753 P28867 Prkcd mouse Y311 447573 TTEsVGIyQGFEKKP X 2055 -Yes1 Yes Q04736 mouse Cortactin 13043 Q60598 Cttn mouse Y466 447703 TyTSEPVyETTEAPG X -TLK1 TLK1 Q9UKI8 human NEK1 4750 Q96PY6 NEK1 human Y315 15412670 ITKPAAKyGIPLAyk X -TLK1 TLK1 Q9UKI8 human AKTIP 64400 Q9H8T0 AKTIP human S237 1876861202 IEDPYAIsFSPWNPS X X -TLK1 TLK1 Q9UKI8 human H3 8350 P68431 H3C1 human S10 455676 tkQtArkstGGkAPr Histone X X 9701; 9711; 9606; 3465; 3642; 3377; 3475; 3458; 5764; 47398; 8481; 8552; 53348; 29237; 66065; 43185; 64522; 52725 -TLK1 TLK1 Q9UKI8 human AKTIP 64400 Q9H8T0 AKTIP human T22 1876861200 RsEGEEKtLtGDVKt X X -TLK1 TLK1 Q9UKI8 human RAD9A 5883 Q99638 RAD9A human T355 449818 EPstVPGtPPPKKFR X X -TLK1 TLK1 Q9UKI8 human RAD9A 5883 Q99638 RAD9A human S328 449812 VLPsIsLsPGPQPPK X X -TLK1 TLK1 Q9UKI8 human MAPKAPK5 8550 Q8IW41 MAPKAPK5 human S160 1876193500 NLLFKDNsLDAPVkL Pkinase X -TLK1 TLK1 Q9UKI8 human NEK1 4750 Q96PY6 NEK1 human T141 65958203 IFLTkDGtVQLGDFG Pkinase X X -TLK1 TLK1 Q9UKI8 human MAPKAPK5 8550 Q8IW41 MAPKAPK5 human S354 27452609 VsLKPLHsVNNPILR X X -TLK1 TLK1 Q9UKI8 human MAPKAPK5 8550 Q8IW41 MAPKAPK5 human S386 1876193502 HENGAEDsNVALEKL X -TLK1 TLK1 Q9UKI8 human NEK1 4750 Q96PY6 NEK1 human S14 51636237 LQKIGEGsFGKAILV Pkinase X -CDK1 CDK1 P06493 human TRIM32 22954 Q13049 TRIM32 human S335 3195095 sPEEVVAsPRAsPAk X -CDK1 CDK1 P06493 human MDM4 4194 O15151 MDM4 human S96 455615 SFSVkDPsPLyDMLR X X -CDK1 CDK1 P06493 human KPNA2 3838 P52292 KPNA2 human S62 459854 sFPDDAtsPLQENRN IBB X X -CDK1 CDK1 P06493 human NuMA-1 4926 Q14980 NUMA1 human T2055 472502 MAFsILNtPkkLGNs X X 14951 -CDK1 CDK1 P06493 human Tau iso8 4137 P10636-8 MAPT human T231 449079 KKVAVVRtPPKsPss X 20473; 71429 -CDK1 CDK1 P06493 human NUDE1 iso1 54820 Q9NXR1-1 NDE1 human S282 469633 RNLVyDQsPNRtGGP NUDE_C X -CDK1 CDK1 P06493 human NCL 4691 P19338 NCL human T121 470366 PGkALVAtPGkkGAA X -CDK1 CDK1 P06493 human SAS6 163786 Q6UVJ0 SASS6 human T495 15414716 DVLGPSTtPPAHsSS X X -CDK1 CDK1 P06493 human STMN1 29332 P13668 Stmn1 rat S38 448556 SVPEFPLsPPKKkDL Stathmin X 3426; 4191 -CDK1 CDK1 P06493 human SIRT3 23410 Q9NTG7 SIRT3 human S159 41655506 SGIPDFRsPGSGLYS SIR2 X X -CDK1 CDK1 P06493 human NDUFB6 4712 O95139 NDUFB6 human S29 23253630 WLkDQELsPREPVLP NDUF_B6 X X -CDK1 CDK1 P06493 human STI1 20867 Q60864 Stip1 mouse T332 2907502 kSLAEHRtPDVLkKC X -CDK1 CDK1 P06493 human ARHGAP19 84986 Q14CB8 ARHGAP19 human T404 27443934 NkQSLTQtPGREPST X X -CDK1 CDK1 P06493 human Chk1 1111 O14757 CHEK1 human S286 465527 tsGGVsEsPsGFskH X -CDK1 CDK1 P06493 human CLASP2 23122 O75122 CLASP2 human S507 481392 QGCsREAsPsRLsVA X -CDK1 CDK1 P06493 human NOLC1 9221 Q14978 NOLC1 human T607 451911 AkKIkLQtPNtFPKR X -CDK1 CDK1 P06493 human NPM1 25498 P13084 Npm1 rat T235 449560 KQEKTPKtPkGPSsV X -CDK1 CDK1 P06493 human ATG13 9776 O75143 ATG13 human T342 1869357206 DRTHCAAtPSSSEDT X -CDK1 CDK1 P06493 human EPB41 iso2 2035 P11171-2 EPB41 human T60 467259 LKASNGDtPTHEDLT X -CDK1 CDK1 P06493 human IP3R1 3708 Q14643 ITPR1 human T800 450269 RDPQEQVtPVKYARL X -CDK1 CDK1 P06493 human ARHGEF2 9181 Q92974 ARHGEF2 human S960 467500 sRLsPPHsPRDFTRM X X -CDK1 CDK1 P06493 human RANGAP1 5905 P46060 RANGAP1 human T409 2906105 GQGEkSAtPSRkILD RanGAP1_C X -CDK1 CDK1 P06493 human VGLL4 iso4 9686 Q14135-4 VGLL4 human T159 3195944 AGLsPTLtPGERQQN VGLL4 X X -CDK1 CDK1 P06493 human SRm300 23524 Q9UQ35 SRRM2 human T1413 468856 VLDAVPRtPsRERss X -CDK1 CDK1 P06493 human CDC27 996 P30260 CDC27 human T209 455849 LtEtPQDtIELNRLN X -CDK1 CDK1 P06493 human NDUFB6 4712 O95139 NDUFB6 human T5 33402202 ___MtGYtPDEkLRL NDUF_B6 X X -CDK1 CDK1 P06493 human GJA1 2697 P17302 GJA1 human S255 448852 HAtsGALsPAkDCGs X -CDK1 CDK1 P06493 human CDC25C 398119 P30309 cdc25c-b frog T48 448419 FSPEQPLtPVTDLAV X -CDK1 CDK1 P06493 human YAP1 10413 P46937 YAP1 human S367 471290 GtQNPVssPGMsQEL X X -CDK1 CDK1 P06493 human MyoD 17927 P10085 Myod1 mouse S5 470072 ___MELLsPPLRDID X -CDK1 CDK1 P06493 human MyoD 17927 P10085 Myod1 mouse S200 40684505 SGDSDASsPRsNCSD Myf5 X -CDK1 CDK1 P06493 human amphiphysin 273 P49418 AMPH human S285 455793 NHTLAPAsPAPARPR X -CDK1 CDK1 P06493 human PAK1 18479 O88643 Pak1 mouse T212 448176 VIEPLPVtPtRDVAt X -CDK1 CDK1 P06493 human p70S6K 6198 P23443 RPS6KB1 human S447 448357 GsPRtPVsPVkFsPG X 9204 -CDK1 CDK1 P06493 human MLL5 55904 Q8IZD2 KMT2E human T912 14645300 PMDPSFAtPPRIKSD X -CDK1 CDK1 P06493 human RGPD4 285190 Q7Z3J3 RGPD4 human S1276 7321780 HAsPLAssPVRKNLF X -CDK1 CDK1 P06493 human HMGA1 3159 P17096 HMGA1 human T78 451516 ktrkttttPGrkPrG X -CDK1 CDK1 P06493 human ERK3 5597 Q16659 MAPK6 human S688 13830503 QFHsPVGsPLkSIQA X -CDK1 CDK1 P06493 human lamin A/C 16905 P48678 Lmna mouse S392 452606 ERLRLsPsPtsQRsR X -CDK1 CDK1 P06493 human treacle 6949 Q13428 TCOF1 human T983 469266 AQAQAAstPRKARAS X -CDK1 CDK1 P06493 human HMGCS1 3157 Q01581 HMGCS1 human S495 467990 IATEHIPsPAkkVPR X -CDK1 CDK1 P06493 human MASTL 84930 Q96GX5 MASTL human S875 3209091 tAQHLtVsGFsL___ X -CDK1 CDK1 P06493 human SLBP 7884 Q14493 SLBP human T62 466352 RRPEsFttPEGPkPR X -CDK1 CDK1 P06493 human DYN2 1785 P50570 DNM2 human S764 3191449 LQsAssHsPtPQRRP X -CDK1 CDK1 P06493 human MORC2 22880 Q9Y6X9 MORC2 human T717 3217917 PsPkVIKtPVVKKtE X -CDK1 CDK1 P06493 human p70S6K 83840 P67999 Rps6kb1 rat S447 448357 GsPRtPVsPVKFsPG X 9204 -CDK1 CDK1 P06493 human VGLL4 iso4 9686 Q14135-4 VGLL4 human S280 458220 SRRGQPAsPSAHMVS X X -CDK1 CDK1 P06493 human PPP1R13L 10848 Q8WUF5 PPP1R13L human S113 465657 LHPysPLsPKGrPss X -CDK1 CDK1 P06493 human EZH2 14056 Q61188 Ezh2 mouse T345 4957354 LtAERIKtPPKRPGG X 45153 -CDK1 CDK1 P06493 human YAP1 10413 P46937 YAP1 human S217 33668511 MNVTAPTsPPVQQNM X -CDK1 CDK1 P06493 human GRASP65 56082 O35254 Gorasp1 rat S376 467957 FEISFPDsPGSQAQV X -CDK1 CDK1 P06493 human FOXO1A 2308 Q12778 FOXO1 human S249 471071 EGGkSGksPrRrAAs X X -CDK1 CDK1 P06493 human SMAD2 Q1W668 SMAD2 cow S245 448794 NQSMDTGsPAELsPT X -CDK1 CDK1 P06493 human NIPA 51530 Q86WB0 ZC3HC1 human S395 478573 PGLEVPssPLRKAKR X -CDK1 CDK1 P06493 human SP1 6667 P08047 SP1 human T737 36897200 AGsEGSGtAtPSALI X X -CDK1 CDK1 P06493 human GRASP65 56082 O35254 Gorasp1 rat T220 4768150 PSAsSPGtPAKtPQP X -CDK1 CDK1 P06493 human PPP1CA 5499 P62136 PPP1CA human T320 448686 NPGGRPItPPRNsAK X 2581 -CDK1 CDK1 P06493 human MYPT1 116670 Q10728 Ppp1r12a rat S432 3545004 EEERKDEsPASWRLG X -CDK1 CDK1 P06493 human KIF20A 10112 O95235 KIF20A human S867 459835 CQsstDCsPyARILR X -CDK1 CDK1 P06493 human NuMA-1 4926 Q14980 NUMA1 human T2106 483675 tAAAIGAtPRAKGKA X -CDK1 CDK1 P06493 human CDC25A 993 P30304 CDC25A human S283 58934700 PErsQEEsPPGSTKr M-inducer_phosp X X -CDK1 CDK1 P06493 human ERK3 5597 Q16659 MAPK6 human S684 13830500 IGIPQFHsPVGsPLk X -CDK1 CDK1 P06493 human CENPA 1058 P49450 CENPA human S68 38520200 LIRKLPFsRLAREIC Histone X X -CDK1 CDK1 P06493 human DLG7 9787 Q15398 DLGAP5 human S839 456341 GGNLItFsPLQPGEF X -CDK1 CDK1 P06493 human MCM3 17215 P25206 Mcm3 mouse T719 449197 tQMPQVHtPKtDDsQ X -CDK1 CDK1 P06493 human PHLPP 23239 O60346 PHLPP1 human S411 1871700802 LPLPQtAssPQPQQK X X -CDK1 CDK1 P06493 human 53BP1 7158 Q12888 TP53BP1 human S1678 476255 ItsEEERsPAKRGRK X -CDK1 CDK1 P06493 human NIFK 84365 Q9BYG3 NIFK human T238 449333 QGPtPVCtPtFLERR hNIFK_binding X -CDK1 CDK1 P06493 human HMGA2 15364 P52927 Hmga2 mouse S59 11452900 PKGSKNKsPSKAAQK X -CDK1 CDK1 P06493 human p73 7161 O15350 TP73 human T86 449047 AASASPYtPEHAASV X X -CDK1 CDK1 P06493 human UBC9 7329 P63279 UBE2I human S71 3803343 FkDDYPssPPkCKFE UQ_con X X -CDK1 CDK1 P06493 human JUB 84962 Q96IF1 AJUBA human S175 17546438 GyDQRHGsPLPAGPC X -CDK1 CDK1 P06493 human CASP9 842 P55211 CASP9 human T125 449563 PEVLRPEtPRPVDIG X X -CDK1 CDK1 P06493 human CDCA5 113130 Q96FF9 CDCA5 human S126 20727702 NPEAEsssKEGELDA Sororin X X -CDK1 CDK1 P06493 human NCKAP5L 57701 Q9HCH0 NCKAP5L human S440 483853 KLQIGPPsPGEAQGP X -CDK1 CDK1 P06493 human CDC16 8881 Q13042 CDC16 human S112 455864 EkYLkDEsGFkDPSS X -CDK1 CDK1 P06493 human USP1 7398 O94782 USP1 human S313 3177796 AtsDtLEsPPKIIPK UCH X -CDK1 CDK1 P06493 human treacle 6949 Q13428 TCOF1 human S583 476272 LQAkPtssPAKGPPQ Treacle X -CDK1 CDK1 P06493 human TK 7083 P04183 TK1 human S13 448816 LPtVLPGsPskTRGQ X -CDK1 CDK1 P06493 human MARK2 2011 Q7KZI7 MARK2 human S569 2192738 PQRVPVAsPsAHNIs X -CDK1 CDK1 P06493 human TSC1 7248 Q92574 TSC1 human T1047 449364 SSSSELstPEKPPHQ X X -CDK1 CDK1 P06493 human CTDSPL2 51496 Q05D32 CTDSPL2 human T86 469354 DNNLITstPRAGEKP X X -CDK1 CDK1 P06493 human CDCA5 113130 Q96FF9 CDCA5 human T111 469415 ktHsVPAtPtStPVP Sororin X X -CDK1 CDK1 P06493 human RAP1GAP 5909 P47736 RAP1GAP human S484 3190705 SLIVPGKsPtRKKsG X -CDK1 CDK1 P06493 human KIF2C 11004 Q99661 KIF2C human T537 14157500 LGQNkAHtPFRESkL Kinesin X X -CDK1 CDK1 P06493 human CC2D1A 54862 Q6P1N0 CC2D1A human S208 483763 PAstPtysPAPtQPA X X -CDK1 CDK1 P06493 human Tip60 10524 Q92993 KAT5 human S86 448826 TKNGLPGsRPGsPER X X -CDK1 CDK1 P06493 human FOXK2 3607 Q01167 FOXK2 human S373 3193955 sSRsAPAsPNHAGVL X X -CDK1 CDK1 P06493 human GMPS 8833 P49915 GMPS human T318 3801478 PIsDEDRtPRKRISk NAD_synthase X -CDK1 CDK1 P06493 human dUTPase iso2 1854 P33316-2 DUT human S11 451166 sEEtPAIsPskRARP X -CDK1 CDK1 P06493 human DAB2IP iso2 153090 Q5VWQ8-2 DAB2IP human T546 3958578 GTNDLAStPGSGSSS DUF3498 X -CDK1 CDK1 P06493 human UGDH 7358 O60701 UGDH human T461 3963109 TIGFQIEtIGKKVSS X -CDK1 CDK1 P06493 human PKR 5610 P19525 EIF2AK2 human S83 3181640 NkEKkAVsPLLLttt X -CDK1 CDK1 P06493 human AML1 iso8 861 Q01196-8 RUNX1 human S276 454399 DTRQIQPsPPWSYDQ X -CDK1 CDK1 P06493 human eIF4G 1981 Q04637 EIF4G1 human S1231 449798 EAALPPVsPLkAALs X X -CDK1 CDK1 P06493 human IREB2 3658 P48200 IREB2 human S157 2850010 LQkAGkLsPLkVQPK X X -CDK1 CDK1 P06493 human TAZ 25937 Q9GZV5 WWTR1 human T285 41594200 AVNPPTMtPDMRsIT X -CDK1 CDK1 P06493 human RAP140 23272 Q9UK61 TASOR human T819 3952772 HEyELNStPDKKDyE X -CDK1 CDK1 P06493 human SRC-1 8648 Q15788 NCOA1 human T1426 18958502 KPTSGPQtPQAQQKS X -CDK1 CDK1 P06493 human AML1 iso8 861 Q01196-8 RUNX1 human S48 452744 TPPSTALsPGKMSEA X -CDK1 CDK1 P06493 human CHMP7 91782 Q8WUX9 CHMP7 human S441 4763991 GLVPSsKsPKRQLEP Snf7 X -CDK1 CDK1 P06493 human DENR 8562 O43583 DENR human S73 476007 AKLtVENsPKQEAGI X -CDK1 CDK1 P06493 human NDUFA12 55967 Q9UI09 NDUFA12 human T120 33402205 HKFNVTGtPEQYVPY NDUFA12 X X -CDK1 CDK1 P06493 human FOXM1 2305 Q08050 FOXM1 human T611 451437 ETLPISstPSkSVLP X -CDK1 CDK1 P06493 human Lamin B1 4001 P20700 LMNB1 human S393 454275 ErLkLsPsPssRVtV X -CDK1 CDK1 P06493 human RCC1 1104 P18754 RCC1 human T274 2850005 SNYHQLGtPGTESCF RCC1 X -CDK1 CDK1 P06493 human KIF22 3835 Q14807 KIF22 human S427 2999003 AsAsQkLsPLQkLSs X -CDK1 CDK1 P06493 human lamin A/C 4000 P02545 LMNA human T19 459855 sGAQAsstPLsPtRI X -CDK1 CDK1 P06493 human CDC14A 8556 Q9UNH5 CDC14A human S453 1216243801 KtSKMALsPSATAKR X X -CDK1 CDK1 P06493 human RFA2 6118 P15927 RPA2 human S29 448338 QsPGGFGsPAPsQAE X -CDK1 CDK1 P06493 human CDKN2D 1032 P55273 CDKN2D human S76 6046001 VQDTSGTsPVHDAAR Ank_2 X X -CDK1 CDK1 P06493 human FLNA 2316 P21333 FLNA human S1630 478650 GGDEIPFsPyRVRAV Filamin X -CDK1 CDK1 P06493 human TOP2A 7153 P11388 TOP2A human S1247 452238 kNENtEGsPQEDGVE X -CDK1 CDK1 P06493 human CDC14A 8556 Q9UNH5 CDC14A human S411 25733761 SQRQPRTsPSCAFRS X X -CDK1 CDK1 P06493 human APC1 64682 Q9H1A4 ANAPC1 human T537 455830 tPLDGVstPkPLsKL X -CDK1 CDK1 P06493 human BLM 641 P54132 BLM human S714 469110 PGVTVVIsPLRSLIV DEAD X -CDK1 CDK1 P06493 human TRF1 7013 P54274 TERF1 human T371 3727647 VSKsQPVtPEKHRAR X X -CDK1 CDK1 P06493 human CDC25B 994 P30305 CDC25B human S321 459625 KCQRLFRsPsMPCsV M-inducer_phosp X -CDK1 CDK1 P06493 human LIMD1 8994 Q9UGP4 LIMD1 human S277 451975 RVsPGLPsPNLENGA X -CDK1 CDK1 P06493 human NUP210 58958 P11654 Nup210 rat S1880 482838 SPPSGLWsPAYASH_ X -CDK1 CDK1 P06493 human AR 367 P10275 AR human S310 448413 TEDTAEysPFKGGYT Androgen_recep X X 61248 -CDK1 CDK1 P06493 human LIMD1 8994 Q9UGP4 LIMD1 human S272 451974 TASsQRVsPGLPsPN X -CDK1 CDK1 P06493 human TFCP2L1 81879 Q3UNW5 Tfcp2l1 mouse T177 38489957 HCISTEFtPRKHGGE CP2 X X -CDK1 CDK1 P06493 human CDC16 8881 Q13042 CDC16 human S560 455866 kTLkNIIsPPWDFRE X -CDK1 CDK1 P06493 human APC1 64682 Q9H1A4 ANAPC1 human S377 455827 NIssHNQsPkRHSIS X -CDK1 CDK1 P06493 human KIF20A 10112 O95235 KIF20A human S878 4712595 RILRsRRsPLLKsGP X -CDK1 CDK1 P06493 human CREM 1390 Q03060 CREM human S277 450066 AsPGsLHsPQQLAEE X X -CDK1 CDK1 P06493 human MAP4 4134 P27816 MAP4 human S696 449564 PNKELPPsPEKKTkP X X -CDK1 CDK1 P06493 human KIF20A 10112 O95235 KIF20A human S532 459833 KEHsLQVsPSLEkGA X -CDK1 CDK1 P06493 human SKA3 221150 Q8IX90 SKA3 human T358 459962 SYENLLRtPtPPEVT X X -CDK1 CDK1 P06493 human Diaphanous-1 1729 O60610 DIAPH1 human T768 3946102 PVLPFGLtPKkLykP X -CDK1 CDK1 P06493 human DLG1 1739 Q12959 DLG1 human S443 5931300 FLGQtPAsPARysPV PDZ_assoc X X -CDK1 CDK1 P06493 human ULK1 22241 O70405 Ulk1 mouse S638 2192504 DFPKtPssQNLLTLL X -CDK1 CDK1 P06493 human CENPC1 1060 Q03188 CENPC human T734 14571365 kLVLPsNtPNVRRTK X X -CDK1 CDK1 P06493 human ATG13 9776 O75143 ATG13 human S44 1869357207 ICTRSSSsPTGSDWF X -CDK1 CDK1 P06493 human CDC25C 995 P30307 CDC25C human S122 449910 DQHLMKCsPAQLLCS X -CDK1 CDK1 P06493 human CK2A1 1457 P68400 CSNK2A1 human T344 449984 SSMPGGStPVSSANM X -CDK1 CDK1 P06493 human MTHFR 4524 P42898 MTHFR human T34 456129 KDSSRCStPGLDPER X X -CDK1 CDK1 P06493 human MCL1 4170 Q07820 MCL1 human S64 479431 IGGSAGAsPPStLtP X 13297 -CDK1 CDK1 P06493 human ULK1 22241 O70405 Ulk1 mouse S622 2047929 PLPPILGsPtKAGPs X -CDK1 CDK1 P06493 human KIF22 3835 Q14807 KIF22 human T463 456110 QGAPLLstPkRERMV X -CDK1 CDK1 P06493 human CDC25C 995 P30307 CDC25C human S168 449022 SEMKyLGsPIttVPK X -CDK1 CDK1 P06493 human Caldesmon 373965 P12957 CALD1 chicken S717 448465 KtPEGNKsPAPKPSD Caldesmon X -CDK1 CDK1 P06493 human Akt1 207 P31749 AKT1 human S473 447855 RPHFPQFsysAsGtA Pkinase_C X 9271; 3787; 4060; 4051; 5102; 4058; 2336; 2337; 4075; 4070; 5012; 4071; 92982; 5315; 9563; 9018; 12694; 52240; 11962; 15116; 88106; 26580; 68035; 31957; 23430; 20235 -CDK1 CDK1 P06493 human USP24 23358 Q9UPU5 USP24 human S2604 3216276 HLQQGsEsPMMIGEL X -CDK1 CDK1 P06493 human AML1 iso8 861 Q01196-8 RUNX1 human T300 454403 sPSVHPAtPIsPGRA X -CDK1 CDK1 P06493 human Raptor 57521 Q8N122 RPTOR human S696 11315003 EKNyALPsPAttEGG X -CDK1 CDK1 P06493 human CDC27 996 P30260 CDC27 human T289 455852 FGILPLEtPsPGDGs X -CDK1 CDK1 P06493 human RAP80 51720 Q96RL1 UIMC1 human S677 453731 TRRDLNEsPVksFVS X X -CDK1 CDK1 P06493 human PHLPP 23239 O60346 PHLPP1 human S321 31863286 RRAsPAPsDssPGEP X X -CDK1 CDK1 P06493 human CDK7 1022 P50613 CDK7 human T170 448306 GsPNRAytHQVVtRW Pkinase X -CDK1 CDK1 P06493 human CDCA5 113130 Q96FF9 CDCA5 human S21 3208968 RsGPRAPsPtKPLRR X X -CDK1 CDK1 P06493 human Nlp 22981 Q9Y2I6 NINL human S589 17490600 NRHsPSWsPDGRRRQ X -CDK1 CDK1 P06493 human Tau iso8 4137 P10636-8 MAPT human S404 449082 PVVsGDtsPRHLsNV X 35834; 20194; 98523; 91600; 49562 -CDK1 CDK1 P06493 human TAZ 25937 Q9GZV5 WWTR1 human T346 41594202 TGENAGQtPMNINPQ X X -CDK1 CDK1 P06493 human DLG7 9787 Q15398 DLGAP5 human S618 456339 AGFFRVEsPVKLFsG X -CDK1 CDK1 P06493 human NFAT2 18018 O88942 Nfatc1 mouse S263 15412721 ARGsRPTsPCNKRKY X X -CDK1 CDK1 P06493 human RARA 19401 P11416 Rara mouse S77 455459 EIVPSPPsPPPLPRI X -CDK1 CDK1 P06493 human JUB 84962 Q96IF1 AJUBA human S119 483805 EPTAPALsPRSsFAs X X -CDK1 CDK1 P06493 human KI-67 4288 P46013 MKI67 human T761 3148266 GIAEMFktPVkEQPQ X -CDK1 CDK1 P06493 human ODF2 iso3 4957 Q5BJF6-3 ODF2 human S796 449230 YSTFLTSsPIRSRSP X -CDK1 CDK1 P06493 human IL16 3603 Q14005 IL16 human T757 11280303 TQGHPDGtPPKLDTA X -CDK1 CDK1 P06493 human SCML2 10389 Q9UQR0 SCML2 human T305 3216633 SssVkNItPRKKGPN RBR X X -CDK1 CDK1 P06493 human ULK1 22241 O70405 Ulk1 mouse T653 23070978 ARQGVVMtPPRNRtL X -CDK1 CDK1 P06493 human NEDD1 121441 Q8NHV4 NEDD1 human S411 3207015 ssLGDMFsPIRDDAV X -CDK1 CDK1 P06493 human USP9X 8239 Q93008 USP9X human S2547 483796 yEGsEEVsPPQtKDQ X X -CDK1 CDK1 P06493 human CDT1 81620 Q9H211 CDT1 human T402 20804634 PrPALPAtPPAtPPA X X -CDK1 CDK1 P06493 human PHLPP 23239 O60346 PHLPP1 human S335 15721886 PFVGGPVssPRAPRP X X -CDK1 CDK1 P06493 human TREX1 22040 Q91XB0 Trex1 mouse S78 2579811 IAPGKACsPGASEIT RNase_T X -CDK1 CDK1 P06493 human KIF20A 10112 O95235 KIF20A human S7 18011282 _MsQGILsPPAGLLs X -CDK1 CDK1 P06493 human CtIP 5932 Q99708 RBBP8 human S327 452473 ELPtRVssPVFGATS X -CDK1 CDK1 P06493 human PKN2 5586 Q16513 PKN2 human S535 3197384 VNHsGtFsPQAPVPT X -CDK1 CDK1 P06493 human CDC25A 993 P30304 CDC25A human S18 449976 RRLLFACsPPPASQP X -CDK1 CDK1 P06493 human CARHSP1 23589 Q9Y2V2 CARHSP1 human T23 3963128 AsVGLLDtPRsRERs X -CDK1 CDK1 P06493 human CDC25B iso2 994 P30305-2 CDC25B human S146 465509 PVRLLGHsPVLRNIT M-inducer_phosp X -CDK1 CDK1 P06493 human amphiphysin 273 P49418 AMPH human S272 455791 EEPsPLPsPTAsPNH X -CDK1 CDK1 P06493 human ATG13 9776 O75143 ATG13 human T332 27444371 QERLATCtPsDRTHC X -CDK1 CDK1 P06493 human Vimentin 7431 P08670 VIM human S55 476052 tsrsLyAssPGGVyA Filament_head X -CDK1 CDK1 P06493 human kindlin-1 55612 Q9BQL6 FERMT1 human S179 2508995 TAsGsSVsPGLYSKT X -CDK1 CDK1 P06493 human CCNB1 891 P14635 CCNB1 human S126 448814 PILVDTAsPsPMETs X X -CDK1 CDK1 P06493 human Bcl-9 607 O00512 BCL9 human T172 3150953 EPtPAQKtPAKVVYV X X -CDK1 CDK1 P06493 human NDEL1 81565 Q9GZM8 NDEL1 human S242 3685801 IPNGFGtsPLtPSAR NUDE_C X -CDK1 CDK1 P06493 human DSN1 79980 Q9H410 DSN1 human S331 10800768 SMQQLDPsPARKLLk MIS13 X -CDK1 CDK1 P06493 human EEF1D 1936 P29692 EEF1D human S133 455672 APQtQHVsPMRQVEP X -CDK1 CDK1 P06493 human CDC25C 995 P30307 CDC25C human T67 448420 LsILsGGtPkRCLDL X -CDK1 CDK1 P06493 human PHLPP 23239 O60346 PHLPP1 human S345 1871700801 RAPRPVVsDTESFSL X X -CDK1 CDK1 P06493 human BAD 572 Q92934 BAD human S91 447861 EGMGEEPsPFrGrsR Bcl-2_BAD X -CDK1 CDK1 P06493 human MEK1 5604 Q02750 MAP2K1 human T292 448287 EtPPRPRtPGRPLss Pkinase X X 26975 -CDK1 CDK1 P06493 human ARHGAP19 84986 Q14CB8 ARHGAP19 human T476 9831746 GsPAVtMtPtRLKWS X X -CDK1 CDK1 P06493 human CK2A1 1457 P68400 CSNK2A1 human S362 449986 ISSVPtPsPLGPLAG X -CDK1 CDK1 P06493 human HMGA1 117062 Q8K585 Hmga1 rat T53 451515 KEPSEVPtPKRPRGR X -CDK1 CDK1 P06493 human RRM2 6241 P31350 RRM2 human T33 3189775 sLVdkENtPPALsGt X 74736 -CDK1 CDK1 P06493 human STMN1 3925 P16949 STMN1 human S25 448555 QAFELILsPrskEsV Stathmin X X -CDK1 CDK1 P06493 human SP1 6667 P08047 SP1 human S720 36897202 GGPGVALsVGtLPLD X X -CDK1 CDK1 P06493 human NDUFS2 4720 O75306 NDUFS2 human S364 33402201 kVDDAKVsPPKRAEM Complex1_49kDa X X -CDK1 CDK1 P06493 human treacle 6949 Q13428 TCOF1 human S156 486513 ANLLsGksPRKsAEP X -CDK1 CDK1 P06493 human CDC25A 993 P30304 CDC25A human S116 449977 PQkLLGCsPALkRSH M-inducer_phosp X -CDK1 CDK1 P06493 human NDEL1 81565 Q9GZM8 NDEL1 human T219 468252 AsLsLPAtPVGKGTE NUDE_C X -CDK1 CDK1 P06493 human DDX3 1654 O00571 DDX3X human T323 457784 GCHLLVAtPGRLVDM DEAD X -CDK1 CDK1 P06493 human RAD9A 5883 Q99638 RAD9A human T355 449818 EPstVPGtPPPKKFR X X -CDK1 CDK1 P06493 human CTDSPL2 51496 Q05D32 CTDSPL2 human S134 4272262 EDNPsSGsPPRTTLL X X -CDK1 CDK1 P06493 human UGDH 83472 O70199 Ugdh rat T461 3963109 TIGFQIEtIGKKVSS X -CDK1 CDK1 P06493 human TSC1 7248 Q92574 TSC1 human S584 450280 ETsIFTPsPCKIPPP Hamartin X X -CDK1 CDK1 P06493 human ISL1 3670 P61371 ISL1 human S269 515814094 GTPMVAAsPERHDGG X -CDK1 CDK1 P06493 human AML1 iso8 861 Q01196-8 RUNX1 human S424 1308915 SMVGGERsPPRILPP RunxI X -CDK1 CDK1 P06493 human POLR2A 5430 P24928 POLR2A human S1920 452274 sPtysPtsPKysPts RNA_pol_Rpb1_R; RNA_pol_Rpb1_R X -CDK1 CDK1 P06493 human SCML2 10389 Q9UQR0 SCML2 human S511 449227 VPyVVPLsPKLPKTk X X -CDK1 CDK1 P06493 human CDCA2 157313 Q69YH5 CDCA2 human T412 3202359 DEsLPANtPLRKGGT PP1_bind X -CDK1 CDK1 P06493 human ORC6L 23594 Q9Y5N6 ORC6 human T195 470324 REPGDVAtPPRKRKk X -CDK1 CDK1 P06493 human kindlin-1 55612 Q9BQL6 FERMT1 human S176 31869918 ssPTAsGsSVsPGLY X -CDK1 CDK1 P06493 human CLASP2 23122 O75122 CLASP2 human S1012 14571702 LHSMPtHssPRsRDy X -CDK1 CDK1 P06493 human CTDSPL2 51496 Q05D32 CTDSPL2 human S104 3205830 ISRVRRKsQVNGEAG X X 5294 -CDK1 CDK1 P06493 human ULK1 22241 O70405 Ulk1 mouse S224 10428802 GKAPFQAsSPQDLRL Pkinase X -CDK1 CDK1 P06493 human Cortactin 2017 Q14247 CTTN human S405 447700 KtQtPPVsPAPQPtE X -CDK1 CDK1 P06493 human NR1D1 217166 Q3UV55 Nr1d1 mouse T275 55578702 SQFPQQLtPPRSPSP X X -CDK1 CDK1 P06493 human 53BP1 27223 P70399 Trp53bp1 mouse S382 452380 TPFIVPssPtEQGGR X -CDK1 CDK1 P06493 human DDHD1 80821 Q8NEL9 DDHD1 human S8 22351354 MNYPGrGsPRsPEHN X -CDK1 CDK1 P06493 human HJURP 55355 Q8NCD3 HJURP human S473 483759 MYRGGPAsPGGLQGL X -CDK1 CDK1 P06493 human NCAPD3 23310 P42695 NCAPD3 human T1415 10790749 VTkRAIstPEKsISD X X -CDK1 CDK1 P06493 human Caldesmon 373965 P12957 CALD1 chicken S597 3302700 KKPFKCFsPKGSsLK Caldesmon X -CDK1 CDK1 P06493 human DDX48 9775 P38919 EIF4A3 human T163 3190132 GQHVVAGtPGRVFDM DEAD X X -CDK1 CDK1 P06493 human GFAP 396562 F1RR02 GFAP pig S8 449618 MERRRVtsAARRsYV Filament_head X -CDK1 CDK1 P06493 human VCIP135 80124 Q96JH7 VCPIP1 human T761 472123 GPssAPAtPtkAPys X X -CDK1 CDK1 P06493 human RGPD5/6 84220 Q99666 RGPD6 human S1275 3963125 HAsPLAssPVRKNLF X -CDK1 CDK1 P06493 human MARK2 2011 Q7KZI7 MARK2 human S456 453135 sTAKVPAsPLPGLER X -CDK1 CDK1 P06493 human NPM1 4869 P06748 NPM1 human T234 449024 sFkkQEKtPKtPkGP X X -CDK1 CDK1 P06493 human NCKAP5L 57701 Q9HCH0 NCKAP5L human S477 3213123 sPGGPQLsPQLPRNS X -CDK1 CDK1 P06493 human CDCA5 113130 Q96FF9 CDCA5 human S181 20727382 AEDLsGVsPVVCsKL Sororin X X -CDK1 CDK1 P06493 human PHLPP 23239 O60346 PHLPP1 human T409 1871700800 QPLPLPQtAssPQPQ X X -CDK1 CDK1 P06493 human CLASP2 23122 O75122 CLASP2 human S1029 3175909 yNysDsIsPFNKsAL X -CDK1 CDK1 P06493 human PKN1 5585 Q16512 PKN1 human S537 483282 GTFsPGAsPGsEART X X -CDK1 CDK1 P06493 human CUEDC2 79004 Q9H467 CUEDC2 human S110 18008416 VQGQVPIsPEPLQRP X X -CDK1 CDK1 P06493 human NuMA-1 308870 F1LW91 Numa1 rat T2021 472502 MAFSILNtPKKLGNS X -CDK1 CDK1 P06493 human LIMD1 8994 Q9UGP4 LIMD1 human S421 3214989 LGSVLLDsPssPRVr X X -CDK1 CDK1 P06493 human desmin 13346 P31001 Des mouse S28 4705787 APGFsLGsPLssPVF Filament_head X -CDK1 CDK1 P06493 human KHDRBS1 10657 Q07666 KHDRBS1 human T317 18504947 rGALVrGtPVrGAIT X -CDK1 CDK1 P06493 human EEF2 1938 P13639 EEF2 human S595 27620701 NVLCLsksPNkHNRL X -CDK1 CDK1 P06493 human KHDRBS1 10657 Q07666 KHDRBS1 human T33 7990374 AHPsVRQtPsrQPPL X -CDK1 CDK1 P06493 human CDC25C 995 P30307 CDC25C human T130 449911 PAQLLCStPNGLDRG X -CDK1 CDK1 P06493 human CDC23 8697 Q9UJX2 CDC23 human T562 454344 QLRNQGEtPttEVPA X -CDK1 CDK1 P06493 human UBXN2B 137886 Q14CS0 UBXN2B human S56 3217941 PkATVFksPRtPPQR X -CDK1 CDK1 P06493 human LATS1 9113 O95835 LATS1 human T490 3146610 ATTVTAItPAPIQQP X -CDK1 CDK1 P06493 human HEC1 10403 O14777 NDC80 human T31 23112540 VNkQGLytPQTKEkP X X -CDK1 CDK1 P06493 human AAK1 22848 Q2M2I8 AAK1 human T389 483910 LPIQPALtPrKRATV X -CDK1 CDK1 P06493 human MCTS1 28985 Q9ULC4 MCTS1 human S118 26348500 IMCPGLTsPGAKLyP PUA X -CDK1 CDK1 P06493 human LIG3 3980 P49916 LIG3 human T191 2883701 LSSKAAGtPKKKAVV X -CDK1 CDK1 P06493 human CDK7 1022 P50613 CDK7 human S164 450041 GLAksFGsPNRAytH Pkinase X -CDK1 CDK1 P06493 human TUBB 22154 P99024 Tubb5 mouse S172 460692 NTFsVVPsPKVSDTV Tubulin X X -CDK1 CDK1 P06493 human RGPD8 727851 O14715 RGPD8 human S1275 7323381 HAsPLAssPVRKNLF X -CDK1 CDK1 P06493 human CREM 1390 Q03060 CREM human S271 450065 QGVVMAAsPGsLHsP X X -CDK1 CDK1 P06493 human MYPT1 116670 Q10728 Ppp1r12a rat S473 3174680 GVIRSASsPRLSSSL X -CDK1 CDK1 P06493 human SETD8 387893 Q9NQR1 KMT5A human S100 3213381 SKIySyMsPNKCSGM X X -CDK1 CDK1 P06493 human Tau iso8 4137 P10636-8 MAPT human T153 449076 DGKtKIAtPRGAAPP X -CDK1 CDK1 P06493 human RANBP2 5903 P49792 RANBP2 human S2280 452315 sALsPsKsPAkLNQs X -CDK1 CDK1 P06493 human POLH 80905 Q9JJN0 Polh mouse S668 4931282 QGKRNPKsPSASSSK X -CDK1 CDK1 P06493 human PHLPP 23239 O60346 PHLPP1 human S412 30988996 PLPQtAssPQPQQKA X X -CDK1 CDK1 P06493 human CDC27 996 P30260 CDC27 human T430 455860 INDsLEItkLDssII X -CDK1 CDK1 P06493 human SOX2 20674 P48432 Sox2 mouse S39 18913847 TGGNQkNsPDRVKRP X -CDK1 CDK1 P06493 human SREBP-1 6720 P36956 SREBF1 human S439 469115 AGsPFQSsPLSLGSR X X -CDK1 CDK1 P06493 human APP 351 P05067 APP human T743 448523 VEVDAAVtPEERHLS APP_amyloid X 3823; 6986 -CDK1 CDK1 P06493 human YAP1 10413 P46937 YAP1 human T119 4959542 AGtAGALtPQHVRAH X X -CDK1 CDK1 P06493 human PD-1 5133 Q15116 PDCD1 human S261 1881448300 PSGMGTSsPARRGSA X -CDK1 CDK1 P06493 human NUSAP1 51203 Q9BXS6 NUSAP1 human T338 3211263 GNsAAVItPFKLttE NUSAP X X -CDK1 CDK1 P06493 human SRm300 23524 Q9UQ35 SRRM2 human T866 453390 QANEQsVtPQRRsCF X -CDK1 CDK1 P06493 human Rb 5925 P06400 RB1 human T252 449821 PINGsPRtPRRGQNR X -CDK1 CDK1 P06493 human TEX14 56155 Q8IWB6 TEX14 human T727 25158903 SNLNNMSttEEYLIS X -CDK1 CDK1 P06493 human BUB1B 701 O60566 BUB1B human S670 3207630 TLsIkkLsPIIEDsR X -CDK1 CDK1 P06493 human STMN1 3925 P16949 STMN1 human S38 448556 sVPEFPLsPPkKkDL Stathmin X X 3426; 4191 -CDK1 CDK1 P06493 human CDC25C 398119 P30309 cdc25c-b frog S205 449022 CEMNILGsPISADPP M-inducer_phosp X -CDK1 CDK1 P06493 human NAGK 55577 Q9UJ70 NAGK human S76 3245045 RsLGLsLsGGDQEDA BcrAD_BadFG X -CDK1 CDK1 P06493 human NCAPG 64151 Q9BPX3 NCAPG human T308 5014903 LNALFSItPLSELVG X -CDK1 CDK1 P06493 human NUP50 10762 Q9UKX7 NUP50 human S221 476622 kVAAEtQsPsLFGst X X -CDK1 CDK1 P06493 human MAP4 4134 P27816 MAP4 human T917 2130501 SAkPssTtPRLSRLA X -CDK1 CDK1 P06493 human AKAP12 9590 Q02952 AKAP12 human T618 480420 AsFkkMVtPKKRVRR WSK X -CDK1 CDK1 P06493 human RANBP2 5903 P49792 RANBP2 human S2246 468567 ssssVHAsPLAssPV X -CDK1 CDK1 P06493 human NUDE1 iso1 54820 Q9NXR1-1 NDE1 human T215 469489 ATGsVPstPIAHRGP NUDE_C X -CDK1 CDK1 P06493 human CDC23 8697 Q9UJX2 CDC23 human T565 455847 NQGEtPttEVPAPFF X -CDK1 CDK1 P06493 human KIFC1 3833 Q9BW19 KIFC1 human S31 3211092 APsQLPLsGsRLKRR X -CDK1 CDK1 P06493 human PIP5K1C 23396 O60331 PIP5K1C human S650 457599 DERSWVysPLHYSAQ X -CDK1 CDK1 P06493 human EFHD2 79180 Q96C19 EFHD2 human S74 478224 QGIGEPQsPsRRVFN X -CDK1 CDK1 P06493 human NUP98 iso2 4928 P52948-2 NUP98 human S606 452729 RDSENLAsPSEYPEN X -CDK1 CDK1 P06493 human BORA 79866 Q6PGQ7 BORA human S252 7533203 SSGQFSSsPIQASAK X -CDK1 CDK1 P06493 human SKA3 221150 Q8IX90 SKA3 human S283 31863083 sDAEytNsPLVPTFC X -CDK1 CDK1 P06493 human CDT1 81620 Q9H211 CDT1 human S411 21440504 PAtPPAAsPsALkGV X X -CDK1 CDK1 P06493 human SQSTM1 8878 Q13501 SQSTM1 human T269 457004 GGkRsRLtPVsPEss X X 13121 -CDK1 CDK1 P06493 human NUP98 iso2 4928 P52948-2 NUP98 human T536 3801389 tPTHYKLtPRPATRV X -CDK1 CDK1 P06493 human NME2 83782 P19804 Nme2 rat T94 3182029 GRVMLGEtNPADskP NDK X -CDK1 CDK1 P06493 human SP1 6667 P08047 SP1 human T739 448227 sEGSGtAtPSALITT X X -CDK1 CDK1 P06493 human ING1 iso2 3621 Q9UK53-2 ING1 human S126 484008 LGDTAGNsGKAGADR X -CDK1 CDK1 P06493 human TTK 7272 P33981 TTK human S281 1737603 VPVNLLNsPDCDVkt X -CDK1 CDK1 P06493 human ADD1 118 P35611 ADD1 human S12 481591 SRAAVVtsPPPtTAP X 84214 -CDK1 CDK1 P06493 human TRIM32 22954 Q13049 TRIM32 human S328 2049721 TFREMDMsPEEVVAs X -CDK1 CDK1 P06493 human VCIP135 80124 Q96JH7 VCPIP1 human S768 3149749 tPtkAPysPttskEK X X -CDK1 CDK1 P06493 human PDK1 5170 O15530 PDPK1 human T354 25256100 WENLHQQtPPKLTAY X -CDK1 CDK1 P06493 human 4E-BP1 1978 Q13541 EIF4EBP1 human S83 447525 PtIPGVtsPssDEPP eIF_4EBP X X -CDK1 CDK1 P06493 human LIG3 3980 P49916 LIG3 human S913 2883700 EkLAtKssPVKVGEK X -CDK1 CDK1 P06493 human HBXAP 51773 Q96T23 RSF1 human S1375 3088513 LPstNGQsPGkAIEN X X -CDK1 CDK1 P06493 human BARD1 580 Q99728 BARD1 human S148 455770 NSIkMWFsPRSkKVR X -CDK1 CDK1 P06493 human BIM iso2 10018 O43521-2 BCL2L11 human S44 449602 QTEPQDRsPAPMSCD X -CDK1 CDK1 P06493 human lamin A/C 4000 P02545 LMNA human S390 452605 EEErLRLsPsPtsQR X -CDK1 CDK1 P06493 human ULK1 22241 O70405 Ulk1 mouse S991 1869357208 HAVQMVQsAALDEMF DUF3543 X -CDK1 CDK1 P06493 human amphiphysin 273 P49418 AMPH human S276 455792 PLPsPTAsPNHTLAP X -CDK1 CDK1 P06493 human PPP2CA 5515 P67775 PPP2CA human T304 450083 EPHVTRRtPDyFl__ X X -CDK1 CDK1 P06493 human NOLC1 64896 P41777 Nolc1 rat T612 451911 SKKVKLQtPNtFPKR X -CDK1 CDK1 P06493 human MORC2 22880 Q9Y6X9 MORC2 human T733 3217920 PIKLsPAtPsRKRsV X -CDK1 CDK1 P06493 human PYCR2 29920 Q96C36 PYCR2 human S304 483394 VSTLTPssPGkLLtR X -CDK1 CDK1 P06493 human CK2A1 1457 P68400 CSNK2A1 human T360 449985 SGISSVPtPsPLGPL X -CDK1 CDK1 P06493 human PRC1 9055 O43663 PRC1 human T481 483541 RrGLAPNtPGkARkL X X -CDK1 CDK1 P06493 human Bcl-xL 598 Q07817 BCL2L1 human S62 449099 PSWHLADsPAVNGAT X -CDK1 CDK1 P06493 human RANBP2 294429 NP_001178533 Ranbp2 rat S2126 468569 HAsPLAssPVRKNLF X -CDK1 CDK1 P06493 human NuMA-1 4926 Q14980 NUMA1 human S2087 28722901 tRSGtRRsPRIATTT X -CDK1 CDK1 P06493 human PAICS 10606 P22234 PAICS human S27 483584 EVyELLDsPGkVLLQ SAICAR_synt X -CDK1 CDK1 P06493 human NME1 191575 Q05982 Nme1 rat S120 450098 GRNIIHGsDSVEsAE NDK X -CDK1 CDK1 P06493 human NuMA-1 4926 Q14980 NUMA1 human T2015 472014 SCFPRPMtPRDRHEG X -CDK1 CDK1 P06493 human YAP1 10413 P46937 YAP1 human S128 485035 QHVRAHssPAsLQLG X X -CDK1 CDK1 P06493 human RANGAP1 19387 P46061 Rangap1 mouse T411 2906105 GSGEEPAtPSRKILD RanGAP1_C X -CDK1 CDK1 P06493 human RFC1 5981 P35251 RFC1 human T506 2915401 KESKLERtPQkNVQG X -CDK1 CDK1 P06493 human OSBP2 23762 Q969R2 OSBP2 human S762 11171320 ECSKVMHssPssPsS Oxysterol_BP X -CDK1 CDK1 P06493 human BAG3 9531 O95817 BAG3 human S284 469168 EGsPARsstPLHsPs X -CDK1 CDK1 P06493 human PICH 54821 Q2NKX8 ERCC6L human T1063 474544 VKQFDAstPkNDIsP X -CDK1 CDK1 P06493 human BRCA2 675 P51587 BRCA2 human S3291 455462 sPICTFVsPAAQKAF X -CDK1 CDK1 P06493 human NDUFV1 4723 P49821 NDUFV1 human T383 33402200 HESCGQCtPCREGVD NADH_4Fe-4S X X -CDK1 CDK1 P06493 human TTDN1 136647 Q8TAP9 MPLKIP human T120 478367 QGsPrTstPFGsGrV MPLKIP X -CDK1 CDK1 P06493 human NUDE1 iso1 54820 Q9NXR1-1 NDE1 human T228 449452 GPsssLNtPGsFRRG NUDE_C X -CDK1 CDK1 P06493 human TEX14 56155 Q8IWB6 TEX14 human T728 25158901 NLNNMSttEEYLISK X -CDK1 CDK1 P06493 human Survivin 332 O15392 BIRC5 human T34 447705 FLEGCACtPERMAEA BIR X X 8888 -CDK1 CDK1 P06493 human UNG 7374 P13051 UNG human S64 2018601 EPGtPPssPLsAEQL X -CDK1 CDK1 P06493 human SMAD2 Q1W668 SMAD2 cow T220 448793 QSNYIPEtPPPGYIS X -CDK1 CDK1 P06493 human SKA3 221150 Q8IX90 SKA3 human T291 459961 PLVPTFCtPGLkIPS X -CDK1 CDK1 P06493 human Vimentin 22352 P20152 Vim mouse S56 451514 sRsLysssPGGAyVt Filament_head X 3877; 7391 -CDK1 CDK1 P06493 human USP16 10600 Q9Y5T5 USP16 human S552 449274 DLEVLtssPtRNLNG UCH X X -CDK1 CDK1 P06493 human BUB1 699 O43683 BUB1 human S593 465612 CNktLAPsPksPGDF X -CDK1 CDK1 P06493 human LIG1 3978 P18858 LIG1 human S76 449246 EEEDEALsPAkGQKP X -CDK1 CDK1 P06493 human DNMT1 1786 P26358 DNMT1 human S154 476108 AkPEPsPsPRITRkS X -CDK1 CDK1 P06493 human MLK3 4296 Q16584 MAP3K11 human S548 4269787 GQAWGRQsPRRLEDs X X -CDK1 CDK1 P06493 human BRCA1 672 P38398 BRCA1 human S114 18007298 FAkKENNsPEHLkDE X -CDK1 CDK1 P06493 human dynactin 6 10671 O00399 DCTN6 human T186 27933603 KTMKGSStPVKN___ X -CDK1 CDK1 P06493 human Rb 5925 P06400 RB1 human S249 447975 AVIPINGsPRtPRRG X -CDK1 CDK1 P06493 human IRS2 8660 Q9Y4H2 IRS2 human S391 1984215 sVAGsPLsPGPVRAP X -CDK1 CDK1 P06493 human Haspin 83903 Q8TF76 HASPIN human T128 3952695 RPPQKCStPCGPLRL X -CDK1 CDK1 P06493 human FOXK2 3607 Q01167 FOXK2 human S428 3193961 FAQsAPGsPLssQPV X -CDK1 CDK1 P06493 human CDC27 996 P30260 CDC27 human T343 455858 sGNsREVtPILAQTQ X -CDK1 CDK1 P06493 human Chk1 1111 O14757 CHEK1 human S301 465528 IQsNLDFsPVNsAss X X -CDK1 CDK1 P06493 human palladin 23022 Q8WX93 PALLD human S766 3963122 SsLPsPMsPTPrQFG X -CDK1 CDK1 P06493 human CDC25B iso2 994 P30305-2 CDC25B human S307 459625 KCQRLFRsPsMPCSV M-inducer_phosp X -CDK1 CDK1 P06493 human NCKAP5L 57701 Q9HCH0 NCKAP5L human S571 3213138 RStFRGPsPEPPPsP X -CDK1 CDK1 P06493 human PITPNM1 9600 O00562 PITPNM1 human S382 451453 DFIDAFAsPVEAEGt X X -CDK1 CDK1 P06493 human TTDN1 136647 Q8TAP9 MPLKIP human S93 478365 YPGSYsrsPAGsQQQ X -CDK1 CDK1 P06493 human NuaK1 9891 O60285 NUAK1 human S445 2023457 TGVLLPssPEAEVPG X -CDK1 CDK1 P06493 human Caldesmon 373965 P12957 CALD1 chicken T688 448467 SsPGGTGtPNKEtAG Caldesmon X -CDK1 CDK1 P06493 human PEX14 64460 Q642G4 Pex14 rat S232 455420 NRRQFPPsPSAPKIP X -CDK1 CDK1 P06493 human HMGA1 3159 P17096 HMGA1 human S36 455950 PRkQPPVsPGtALVG X -CDK1 CDK1 P06493 human NUDE1 iso1 54820 Q9NXR1-1 NDE1 human T246 467025 stGGtPLtPAARISA NUDE_C X X -CDK1 CDK1 P06493 human CDC27 996 P30260 CDC27 human S312 455855 PPVIDVPstGAPSKk X -CDK1 CDK1 P06493 human RRM2 6241 P31350 RRM2 human S20 457399 DPQQLQLsPLkGLsL X -CDK1 CDK1 P06493 human NCL 4691 P19338 NCL human T641 21697920 EIDGNkVtLDWAkPK RRM_1 X X -CDK1 CDK1 P06493 human OSBP2 23762 Q969R2 OSBP2 human S766 15721694 VMHssPssPsSDGKQ Oxysterol_BP X -CDK1 CDK1 P06493 human ECT2 1894 Q9H8V3 ECT2 human T444 457522 TKSSKSStPVPskQS X -CDK1 CDK1 P06493 human NPM1 4869 P06748 NPM1 human T199 448515 VkKsIrDtPAkNAQK X X 3541; 75984 -CDK1 CDK1 P06493 human LIG3 3980 P49916 LIG3 human S210 468127 TttGQVtsPVkGAsF X -CDK1 CDK1 P06493 human BRCA1 672 P38398 BRCA1 human S1497 448730 EPGVERssPsKCPsL X X -CDK1 CDK1 P06493 human RAB5B 5869 P61020 RAB5B human S123 457392 kELQRQAsPsIVIAL Ras X -CDK1 CDK1 P06493 human LDH-A 3939 P00338 LDHA human T248 3883800 VIkLkGYtsWAIGLS Ldh_1_C X -CDK1 CDK1 P06493 human NUCKS 64710 Q9H1E3 NUCKS1 human S181 452956 LkAtVtPsPVkGkGk X -CDK1 CDK1 P06493 human BRCA1 672 P38398 BRCA1 human S1189 450007 QKGELsRsPsPFtHT X X -CDK1 CDK1 P06493 human TPX2 22974 Q9ULW0 TPX2 human S738 453052 QPLtVPVsPkFsTRF X -CDK1 CDK1 P06493 human Jun 24516 P17325 Jun rat S63 447686 KNSDLLtsPDVGLLK Jun X 5464; 9261; 2361; 97721; 91952 -CDK1 CDK1 P06493 human desmin 13346 P31001 Des mouse S7 466342 _MSQAYsssQRVSSY X -CDK1 CDK1 P06493 human Rab4 5867 P20338 RAB4A human S204 451289 AALRQLRsPRRAQAP X -CDK1 CDK1 P06493 human NCKAP5L 57701 Q9HCH0 NCKAP5L human S767 3213144 RVDLEPVsPRSCLTk X -CDK1 CDK1 P06493 human PHLPP 23239 O60346 PHLPP1 human S450 36134756 VAPGGLQstPGRSGV X X -CDK1 CDK1 P06493 human CDCA5 113130 Q96FF9 CDCA5 human S139 20727378 DARDLEMsKKVRRsy Sororin X X -CDK1 CDK1 P06493 human REPS2 9185 Q8NFH8 REPS2 human S463 480114 RPRsRsyssTsIEEA X -CDK1 CDK1 P06493 human IP3R1 16438 P11881 Itpr1 mouse S421 450268 VMLKIGTsPLKEDkE MIR X X -CDK1 CDK1 P06493 human RIT1 6016 Q92963 RIT1 human S209 6424741 SVWKRLKsPFRKkKD X -CDK1 CDK1 P06493 human RPS3 6188 P23396 RPS3 human T221 452652 kDEILPttPIsEQkG X X -CDK1 CDK1 P06493 human PHLPP 23239 O60346 PHLPP1 human S324 31871709 sPAPsDssPGEPFVG X X -CDK1 CDK1 P06493 human RARA 19401 P11416 Rara mouse S461 455330 RSsPATQsP______ X -CDK1 CDK1 P06493 human SPAG5 10615 Q96R06 SPAG5 human S249 460404 PSSVLWLsPSTALAA X X -CDK1 CDK1 P06493 human CDC27 996 P30260 CDC27 human S435 455862 EItkLDssIIsEGkI X -CDK1 CDK1 P06493 human ACSL4 2182 O60488 ACSL4 human S447 23079030 LSGGAPLsPQTHRFM AMP-binding X X -CDK1 CDK1 P06493 human kindlin-2 10979 Q96AC1 FERMT2 human S181 3208614 GsGsIyssPGLyskT X X -CDK1 CDK1 P06493 human MASTL 84930 Q96GX5 MASTL human T194 3209097 NMMDILTtPSMAkPR Pkinase X -CDK1 CDK1 P06493 human GRP58 2923 P30101 PDIA3 human S456 3963114 GFPtIyFsPANkKLN Thioredoxin X -CDK1 CDK1 P06493 human PIK3C3 5289 Q8NEB9 PIK3C3 human T159 14659500 DGSEPTktPGRtssT PI3K_C2 X X -CDK1 CDK1 P06493 human Calnexin 29144 P35565 Canx rat S582 449100 EDEILNRsPRNRKPR X -CDK1 CDK1 P06493 human lamin A/C 4000 P02545 LMNA human S22 452604 QAsstPLsPtRItRL X X 2026; 13448 -CDK1 CDK1 P06493 human FLNA 2316 P21333 FLNA human S1084 452265 LQGGsAGsPArFtID Filamin X -CDK1 CDK1 P06493 human AML1 iso8 861 Q01196-8 RUNX1 human S303 454401 VHPAtPIsPGRASGM X -CDK1 CDK1 P06493 human KIF20B 9585 Q96Q89 KIF20B human T1644 10783141 VKHPGCttPVtVKIP X -CDK1 CDK1 P06493 human JARID1B 10765 Q9UGL1 KDM5B human S1456 15404114 FkLERERsYELVRSA X X -CDK1 CDK1 P06493 human AML3 860 Q13950 RUNX2 human S465 460684 MVPGGDRsPSRMLPP RunxI X X -CDK1 CDK1 P06493 human Chk1 12649 O35280 Chek1 mouse S286 465527 TsGGMSEsSSGFSKH X -CDK1 CDK1 P06493 human Bcl-2 596 P10415 BCL2 human S87 448396 AAAGPALsPVPPVVH X -CDK1 CDK1 P06493 human p27Kip1 1027 P46527 CDKN1B human T187 447875 NAGsVEQtPKKPGLR X -CDK1 CDK1 P06493 human TAZ 25937 Q9GZV5 WWTR1 human S105 3211881 tGAGAAGsPAQQHAH X X -CDK1 CDK1 P06493 human BAD 12015 Q61337 Bad mouse S128 447861 EGMEEELsPFRGRsR Bcl-2_BAD X -CDK1 CDK1 P06493 human p70S6K 83840 P67999 Rps6kb1 rat S441 450015 sPRRFIGsPRtPVsP X -CDK1 CDK1 P06493 human TOP2A 7153 P11388 TOP2A human S1361 455094 sPPKTKtsPKLsNkE X -CDK1 CDK1 P06493 human RAD9A 5883 Q99638 RAD9A human S328 449812 VLPsIsLsPGPQPPK X X -CDK1 CDK1 P06493 human RANBP2 5903 P49792 RANBP2 human T2153 3191215 LLDIPLQtPHkLVDt X -CDK1 CDK1 P06493 human kindlin-2 10979 Q96AC1 FERMT2 human S186 15226813 yssPGLyskTMTPty X X -CDK1 CDK1 P06493 human Wee1 7465 P30291 WEE1 human S123 451132 EEGFGsSsPVKsPAA X -CDK1 CDK1 P06493 human MCL1 4170 Q07820 MCL1 human T92 4825134 EVPDVTAtPARLLFF X X -CDK1 CDK1 P06493 human CDCA5 113130 Q96FF9 CDCA5 human S33 472118 LRRsQRKsGsELPsI X X -CDK1 CDK1 P06493 human BARD1 580 Q99728 BARD1 human S251 455769 sQPSVISsPQINGEI X -CDK1 CDK1 P06493 human FLNA 2316 P21333 FLNA human S1533 478649 GDEEVPRsPFKVkVL Filamin X -CDK1 CDK1 P06493 human SP1 6667 P08047 SP1 human T723 36897201 GVALsVGtLPLDsGA X X -CDK1 CDK1 P06493 human SMAD2 Q1W668 SMAD2 cow S255 448796 ELsPTTLsPVNHSLD X -CDK1 CDK1 P06493 human VGLL4 iso4 9686 Q14135-4 VGLL4 human S58 478547 RTGPPPIsPSKRKFS VGLL4 X X -CDK1 CDK1 P06493 human PHLPP 23239 O60346 PHLPP1 human S336 27454806 FVGGPVssPRAPRPV X X -CDK1 CDK1 P06493 human NPM1 25498 P13084 Npm1 rat S70 459898 EAMNyEGsPIKVTLA Nucleoplasmin X -CDK1 CDK1 P06493 human PRDX1 5052 Q06830 PRDX1 human T90 455554 CHLAWVNtPkkQGGL AhpC-TSA X X -CDK1 CDK1 P06493 human RAD9A 5883 Q99638 RAD9A human S277 449811 SHsQDLGsPERHQPV X X -CDK1 CDK1 P06493 human NCKAP5L 57701 Q9HCH0 NCKAP5L human S451 483854 AQGPLLPsPARGLKF X -CDK1 CDK1 P06493 human PTP1B 5770 P18031 PTPN1 human S386 447810 LrGAQAAsPAKGEPs X -CDK1 CDK1 P06493 human SPAG5 10615 Q96R06 SPAG5 human S135 460403 KTIVLVPsPLGQQQD X X -CDK1 CDK1 P06493 human APRIN 23047 Q9NTI5 PDS5B human T1370 467472 AIEstQstPQKGRGR X -CDK1 CDK1 P06493 human Tau iso8 4137 P10636-8 MAPT human S202 447928 sGyssPGsPGtPGsR X 39357; 30505 -CDK1 CDK1 P06493 human ECT2 1894 Q9H8V3 ECT2 human T373 456870 VsMLsLNtPNsNRKR X X -CDK1 CDK1 P06493 human KPNA2 3838 P52292 KPNA2 human T9 11536044 stNENANtPAARLHR X X -CDK1 CDK1 P06493 human MYPT1 116670 Q10728 Ppp1r12a rat S601 3545005 AKTPPGSsPAGTQSS X -CDK1 CDK1 P06493 human STIM1 6786 Q13586 STIM1 human S668 484156 IGEEtDssPGRKKFP X -CDK1 CDK1 P06493 human PKM 5315 P14618 PKM human S37 476070 MCRLDIDsPPItARN X X -CDK1 CDK1 P06493 human UHRF1 29128 Q96T88 UHRF1 human S639 471011 QQEGGFAsPRTGkGk X X -CDK1 CDK1 P06493 human ATG13 9776 O75143 ATG13 human S224 53377101 DRPYPSSsPMHPCNY X -CDK1 CDK1 P06493 human epsin 1 29924 Q9Y6I3 EPN1 human S382 3178200 FSDPWGGsPAKPSTN X -CDK1 CDK1 P06493 human DENR 8562 O43583 DENR human T69 476008 PNEFAKLtVENsPKQ X -CDK1 CDK1 P06493 human ZNF261 9203 Q14202 ZMYM3 human T826 3801541 PPPPPPAtPRKNKAA X -CDK1 CDK1 P06493 human kindlin-2 10979 Q96AC1 FERMT2 human S175 3208608 GPLItPGsGsIyssP X X -CDK1 CDK1 P06493 human MEK1 170851 Q01986 Map2k1 rat T292 448287 EtPPRPRtPGRPLsS Pkinase X 26975 -CDK1 CDK1 P06493 human p21Cip1 1026 P38936 CDKN1A human S130 455618 sGEQAEGsPGGPGDs X X -CDK1 CDK1 P06493 human EML3 256364 Q32P44 EML3 human T881 483690 GAGPAPAtPsRtPsL X X -CDK1 CDK1 P06493 human APC1 64682 Q9H1A4 ANAPC1 human S373 455826 VQRFNIssHNQsPkR X -CDK1 CDK1 P06493 human TPR 7175 P12270 TPR human S2073 468981 QAPRAPQsPRRPPHP X X -CDK1 CDK1 P06493 human TOP2B 7155 Q02880 TOP2B human S1424 3194111 DKDEytFsPGKsKAt X -CDK1 CDK1 P06493 human NDEL1 81565 Q9GZM8 NDEL1 human T245 3211851 GFGtsPLtPSARISA NUDE_C X -CDK1 CDK1 P06493 human INCENP 16319 Q9WU62 Incenp mouse T388 458333 ATKIAIStPTSKPAA X -CDK1 CDK1 P06493 human RRM2 20135 P11157 Rrm2 mouse S20 457399 DQQQLQLsPLKRLTL X -CDK1 CDK1 P06493 human OGFR 11054 Q9NZT2 OGFR human S378 2906773 EDRPEPLsPKEsKKR X -CDK1 CDK1 P06493 human DNCLI1 420668 Q90828 DYNC1LI1 chicken S197 454199 PGEDFPAsPQRRNTS DLIC X -CDK1 CDK1 P06493 human RECQL4 9401 O94761 RECQL4 human S251 25173044 EVSIRVGsPQPSSSG X X -CDK1 CDK1 P06493 human RGPD3 653489 A6NKT7 RGPD3 human S1276 3963101 HAsPLAssPVRKNLF X -CDK1 CDK1 P06493 human RAD9A 5883 Q99638 RAD9A human S336 449816 PGPQPPKsPGPHsEE X X -CDK1 CDK1 P06493 human PHF8 23133 Q9UPP1 PHF8 human S120 453946 GKPVkTGsPtFVREL X -CDK1 CDK1 P06493 human APC1 64682 Q9H1A4 ANAPC1 human S547 455831 PLsKLLGsLDEVVLL X -CDK1 CDK1 P06493 human APC1 64682 Q9H1A4 ANAPC1 human S688 452953 FDFEGsLsPVIAPkk Apc1_MidN X -CDK1 CDK1 P06493 human ECT2 1894 Q9H8V3 ECT2 human T846 457521 RAFsFsktPKRALRR X X -CDK1 CDK1 P06493 human DDHD1 80821 Q8NEL9 DDHD1 human S11 22351356 PGrGsPRsPEHNGRG X -CDK1 CDK1 P06493 human EZH2 2146 Q15910 EZH2 human T487 452848 APAEDVDtPPRKKKR X X -CDK1 CDK1 P06493 human CDC25C 398119 P30309 cdc25c-b frog T67 448420 LSTFSGEtPKRCLDL X -CDK1 CDK1 P06493 human SIRT3 23410 Q9NTG7 SIRT3 human T150 41655507 MVGAGIStPSGIPDF SIR2 X X -CDK1 CDK1 P06493 human hnRNP K 117282 P61980 Hnrnpk rat S216 450148 ILDLISEsPIkGRAQ X -CDK1 CDK1 P06493 human LRRK1 79705 Q38SD2 LRRK1 human T1427 41694202 GALGVEGtPGyQAPE Pkinase X -CDK1 CDK1 P06493 human RNMT 8731 O43148 RNMT human T77 454561 SSSCGKDtPsKKRKL X X -CDK1 CDK1 P06493 human NUP98 iso2 4928 P52948-2 NUP98 human T529 3149520 AAQKALttPTHYKLt X -CDK1 CDK1 P06493 human p70S6K 6198 P23443 RPS6KB1 human S394 448806 TRQtPVDsPDDStLS Pkinase_C X 9208 -CDK1 CDK1 P06493 human NOLC1 9221 Q14978 NOLC1 human T610 451912 IkLQtPNtFPKRKKG X -CDK1 CDK1 P06493 human AHNAK 79026 Q09666 AHNAK human S5763 483522 EAEAEAssPkGKFsL X -CDK1 CDK1 P06493 human ULK1 22241 O70405 Ulk1 mouse S629 27460648 sPtKAGPsFDFPKtP X -CDK1 CDK1 P06493 human PSMA5 5686 P28066 PSMA5 human S16 483589 DrGVNtFsPEGrLFQ Proteasome_A_N X -CDK1 CDK1 P06493 human CDC27 996 P30260 CDC27 human T205 455848 PEtVLtEtPQDtIEL X -CDK1 CDK1 P06493 human MCM3 17215 P25206 Mcm3 mouse S611 2840506 SSDTARTsPVTARTL MCM_lid X -CDK1 CDK1 P06493 human ASE-1 10849 O15446 POLR1G human S285 453847 PLEDtVLsPtKKRKR X -CDK1 CDK1 P06493 human lamin A/C 60374 P48679 Lmna rat S22 452604 QASStPLsPTRITRL X 2026; 13448 -CDK1 CDK1 P06493 human NUDE1 iso1 54820 Q9NXR1-1 NDE1 human T243 469634 LDDstGGtPLtPAAR NUDE_C X -CDK1 CDK1 P06493 human NDUFV3 4731 P56181 NDUFV3 human S105 4751741 QPssGREsPRH____ X X -CDK1 CDK1 P06493 human SGO1 151648 Q5FBB7 SGO1 human T346 15406076 LEEGVHLtPFRQKVS X X -CDK1 CDK1 P06493 human PHF8 23133 Q9UPP1 PHF8 human S69 15108901 CQDWFHGsCVGVEEE PHD X -CDK1 CDK1 P06493 human RAMP 51514 Q9NZJ0 DTL human T464 4717290 DLPLPsNtPTFSIKt X X -CDK1 CDK1 P06493 human CDC25C 995 P30307 CDC25C human S214 448417 sRsGLyRsPsMPENL M-inducer_phosp X X -CDK1 CDK1 P06493 human EEF2K 29904 O00418 EEF2K human S359 447826 GtEEKCGsPQVRtLs X X -CDK1 CDK1 P06493 human NUSAP1 51203 Q9BXS6 NUSAP1 human T300 7989914 HKRsLtKtPARksAH NUSAP X X -CDK1 CDK1 P06493 human DEPDC1 55635 Q5TB30 DEPDC1 human S110 31082615 LFRFPAtsPLkTLPR X X -CDK1 CDK1 P06493 human SKA3 221150 Q8IX90 SKA3 human T203 1869388600 sLVkVLKtPKCALkM X -CDK1 CDK1 P06493 human PIK3C2A 5286 O00443 PIK3C2A human S259 449059 kVSNLQVsPkSEDIS X X -CDK1 CDK1 P06493 human KIFC1 3833 Q9BW19 KIFC1 human S26 477789 RPLIkAPsQLPLsGs X -CDK1 CDK1 P06493 human SSR1 6745 P43307 SSR1 human S268 3072271 LNQINkAsPRRLPRK TRAP_alpha X -CDK1 CDK1 P06493 human p70S6K 83840 P67999 Rps6kb1 rat S434 448356 SFEPKIRsPRRFIGs X -CDK1 CDK1 P06493 human HIF1A 3091 Q16665 HIF1A human S668 11073382 DTQSRTAsPNRAGkG X -CDK1 CDK1 P06493 human Lamin B1 4001 P20700 LMNB1 human S23 455421 GGPttPLsPtRLsRL X -CDK1 CDK1 P06493 human E2F1 1869 Q01094 E2F1 human S332 447868 TDSATIVsPPPSsPP X -CDK1 CDK1 P06493 human TEX14 56155 Q8IWB6 TEX14 human T618 25158902 EEASSPStGQPSLCS X -CDK1 CDK1 P06493 human XIAP 331 P98170 XIAP human S40 31884865 FANFPSGsPVSAstL BIR X -CDK1 CDK1 P06493 human VGLL4 iso4 9686 Q14135-4 VGLL4 human S155 3195941 ASRPAGLsPTLtPGE VGLL4 X X -CDK1 CDK1 P06493 human BUB1B 701 O60566 BUB1B human S1043 483373 WkVGkLtsPGALLFQ X -CDK1 CDK1 P06493 human BARD1 580 Q99728 BARD1 human T299 455768 KSRNEVVtPEKVCkN X -CDK1 CDK1 P06493 human DDHD1 80821 Q8NEL9 DDHD1 human S727 465585 TIPsPVtsPVLSRRH DDHD X -CDK1 CDK1 P06493 human CUTL1 13047 P53564 Cux1 mouse S1232 456479 IDYSQGAsPQPQHQL X -CDK1 CDK1 P06493 human CDCA5 113130 Q96FF9 CDCA5 human S209 3208965 DMtLPGIsPPPEKQK Sororin X X -CDK1 CDK1 P06493 human SLX4 84464 Q8IY92 SLX4 human T1544 1880104206 QKPEGLEtPKGANRK X -CDK1 CDK1 P06493 human ERK3 5597 Q16659 MAPK6 human T698 13830502 kSIQATLtPSAMkss X X -CDK1 CDK1 P06493 human UBE2A 7319 P49459 UBE2A human S120 448007 LDEPNPNsPANSQAA UQ_con X X -CDK1 CDK1 P06493 human RECQL5 9400 O94762 RECQL5 human S727 4767154 sAHYGGPsPEKKAKS RecQ5 X X -CDK1 CDK1 P06493 human kindlin-1 55612 Q9BQL6 FERMT1 human S174 3210720 LEssPTAsGsSVsPG X -CDK1 CDK1 P06493 human HMGA1 117062 Q8K585 Hmga1 rat T78 451516 KTRKVTTtPGRKPRG X -CDK1 CDK1 P06493 human FOXM1 iso2 2305 Q08050-2 FOXM1 human T596 451437 ETLPISStPSKSVLP X X -CDK1 CDK1 P06493 human TAZ 25937 Q9GZV5 WWTR1 human T326 41594201 GCySVPTtPEDFLSN X X -CDK1 CDK1 P06493 human CDC25C 995 P30307 CDC25C human T48 448419 VCPDVPRtPVGkFLG X 9527; 12028 -CDK1 CDK1 P06493 human SRC-3 8202 Q9Y6Q9 NCOA3 human S867 454107 sPVsVGssPPVKNIS X -CDK1 CDK1 P06493 human CK2B 1460 P67870 CSNK2B human S209 451751 QAAsNFksPVktIR_ X -CDK1 CDK1 P06493 human Wee1 7465 P30291 WEE1 human S139 449250 yFLGSsFsPVRCGGP X -CDK1 CDK1 P06493 human MEK1 170851 Q01986 Map2k1 rat T286 448286 VEGDAAEtPPRPRtP Pkinase X 9127 -CDK1 CDK1 P06493 human TFPT 29844 P0C1Z6 TFPT human S180 451482 PAPPEPGsPAPGEGP X -CDK1 CDK1 P06493 human BUB1 699 O43683 BUB1 human T609 465611 sAAQLAstPFHkLPV X -CDK1 CDK1 P06493 human separase 9700 Q14674 ESPL1 human S1126 447673 IAPStNSsPVLKTKP X -CDK1 CDK1 P06493 human TSC1 7248 Q92574 TSC1 human T417 450279 SLPQATVtPPRKEER Hamartin X X -CDK1 CDK1 P06493 human FEN1 2237 P39748 FEN1 human S187 2708400 MDCLTFGsPVLMrHL XPG_I X X -CDK1 CDK1 P06493 human KIF20A 10112 O95235 KIF20A human T198 32007200 LQGQLHPtPDLKPLL Kinesin X -CDK1 CDK1 P06493 human BAG3 9531 O95817 BAG3 human T285 467534 GsPARsstPLHsPsP X X -CDK1 CDK1 P06493 human ATAD5 79915 Q96QE3 ATAD5 human S653 3209715 TVPFDsEsPIRMKFt X -CDK1 CDK1 P06493 human CK2A1 1457 P68400 CSNK2A1 human S370 449987 PLGPLAGsPVIAAAN X -CDK1 CDK1 P06493 human SLX4 84464 Q8IY92 SLX4 human T1571 1880104210 PQYSIMEtPVLkKEL X -CDK1 CDK1 P06493 human PKN1 5585 Q16512 PKN1 human S562 483683 LGtDsDssPQkSSRD X X -CDK1 CDK1 P06493 human DDX3 1654 O00571 DDX3X human T204 457783 LTRyTRPtPVQkHAI DEAD X X -CDK1 CDK1 P06493 human ERCC6 2074 Q03468 ERCC6 human T1031 1875831800 GTGSDVQtPKCHLKR X -CDK1 CDK1 P06493 human U2AF2 11338 P26368 U2AF2 human S79 470379 EHGGLIRsPRHEKKK X -CDK1 CDK1 P06493 human UBXN2B 137886 Q14CS0 UBXN2B human T59 3217944 TVFksPRtPPQRFys X -CDK1 CDK1 P06493 human PHLPP 23239 O60346 PHLPP1 human S317 25172982 GGWsRRAsPAPsDss X X -CDK1 CDK1 P06493 human NCAPG 64151 Q9BPX3 NCAPG human T931 471738 KNKEVyMtPLrGVkA X -CDK1 CDK1 P06493 human LBR 3930 Q14739 LBR human S71 450689 KGGsTsSsPSRRRGS X -CDK1 CDK1 P06493 human DISC1 244667 Q811T9 Disc1 mouse S710 18942700 QLQEAGSsPHAEDEE X -CDK1 CDK1 P06493 human CDC27 996 P30260 CDC27 human S222 455850 LNLEssNsKYSLNTD X -CDK1 CDK1 P06493 human 4E-BP1 1978 Q13541 EIF4EBP1 human T70 447528 rNsPVtktPPRDLPt eIF_4EBP X 9455; 13396 -CDK1 CDK1 P06493 human EPB41 iso2 2035 P11171-2 EPB41 human S679 467260 DKRLSTHsPFRTLNI SAB X -CDK1 CDK1 P06493 human DISC1 27185 Q9NRI5 DISC1 human S713 18942700 QLQEARGsLSVEDER X -CDK1 CDK1 P06493 human STI1 20867 Q60864 Stip1 mouse T198 465576 DEEEEAAtPPPPPPP X -CDK1 CDK1 P06493 human NSFL1C 55968 Q9UNZ2 NSFL1C human S140 455619 AVERVTksPGETSkP X X -CDK1 CDK1 P06493 human MEK1 5604 Q02750 MAP2K1 human T286 448286 VEGdAAEtPPRPRtP Pkinase X X 9127 -CDK1 CDK1 P06493 human NUDE1 iso1 54820 Q9NXR1-1 NDE1 human T191 20722719 QKQEKPRtPMPSSVE NUDE_C X -CDK1 CDK1 P06493 human FANCG 2189 O15287 FANCG human S387 454240 PRFsPPPsPPGPCMP X -CDK1 CDK1 P06493 human DAB2IP iso2 153090 Q5VWQ8-2 DAB2IP human T531 1875342306 DVHTALStPGSGQLP DUF3498 X -CDK1 CDK1 P06493 human INCENP 16319 Q9WU62 Incenp mouse T59 458332 EPELMPKtPSQKNRR X -CDK1 CDK1 P06493 human DLG1 1739 Q12959 DLG1 human S158 2024309 FVsHsHIsPIKPTEA MAGUK_N_PEST X X -CDK1 CDK1 P06493 human NCKAP5L 57701 Q9HCH0 NCKAP5L human S577 3213141 PsPEPPPsPLQVPTY X -CDK1 CDK1 P06493 human KIF20A 10112 O95235 KIF20A human T857 471862 LRNLLPRtPtCQsst X -CDK1 CDK1 P06493 human U2AF2 308335 F2Z3T9 U2af2 rat S79 470379 EHGGLIRsPRHEKKK X -CDK1 CDK1 P06493 human SKA3 221150 Q8IX90 SKA3 human T217 3205641 MDDFECVtPKLEHFG X -CDK1 CDK1 P06493 human GRASP65 56082 O35254 Gorasp1 rat T224 4768154 SPGtPAKtPQPNAFP X -CDK1 CDK1 P06493 human POLR2A 5430 P24928 POLR2A human S1934 452275 sPtysPtsPKGSTYs X -CDK1 CDK1 P06493 human RFA2 6118 P15927 RPA2 human S33 448339 GFGsPAPsQAEkkSR X 10148 -CDK1 CDK1 P06493 human PKN1 5585 Q16512 PKN1 human S916 452442 TGEAPtLsPPRDARP Pkinase_C X X -CDK1 CDK1 P06493 human SET 6418 Q01105 SET human S7 455972 _MAPKRQsPLPPQKK X X -CDK1 CDK1 P06493 human APC4 29945 Q9UJX5 ANAPC4 human S779 455839 kEEVLsEsEAENQQA X -CDK1 CDK1 P06493 human CEP55 55165 Q53EZ4 CEP55 human S425 457628 NREKVAAsPksPtAA X -CDK1 CDK1 P06493 human TRF1 7013 P54274 TERF1 human T344 3793900 KKERRVGtPQsTKKK X -CDK1 CDK1 P06493 human PRPS1 5631 P60891 PRPS1 human S103 56655989 RQDKKDKsRAPISAK Pribosyltran_N X X -CDK1 CDK1 P06493 human BLM 641 P54132 BLM human T766 469111 IIKLLYVtPEkICAs DEAD X -CDK1 CDK1 P06493 human GAPVD1 26130 Q14C86 GAPVD1 human S950 483086 APHsssssPsKDssR X -CDK1 CDK1 P06493 human NPM1 4869 P06748 NPM1 human S70 459898 EAMNyEGsPIkVtLA Nucleoplasmin X -CDK1 CDK1 P06493 human NEDD1 121441 Q8NHV4 NEDD1 human S460 20609205 STSVLHSsPLNVFMG X X -CDK1 CDK1 P06493 human GJA1 2697 P17302 GJA1 human S262 450694 sPAkDCGsQkyAyFN X -CDK1 CDK1 P06493 human NME2 4831 P22392 NME2 human T94 3182029 GrVMLGEtNPADskP NDK X -CDK1 CDK1 P06493 human WAC 51322 Q9BTA9 WAC human T482 469446 ssQPKVStPVVkQGP X X -CDK1 CDK1 P06493 human NICE-4 9898 Q14157 UBAP2L human S454 452474 AAPPPPssPLPsKst X -CDK1 CDK1 P06493 human RAB11FIP3 9727 O75154 RAB11FIP3 human S102 25126702 GPRGQLAsPDAPGPG X -CDK1 CDK1 P06493 human HJURP 55355 Q8NCD3 HJURP human S448 3206595 LHREyCLsPRNQPRR HJURP_C X -CDK1 CDK1 P06493 human CDCA5 113130 Q96FF9 CDCA5 human T48 472119 LPEIWPKtPsAAAVR X X -CDK1 CDK1 P06493 human NME1 4830 P15531 NME1 human T94 3180917 GrVMLGEtNPADskP NDK X -CDK1 CDK1 P06493 human APC1 64682 Q9H1A4 ANAPC1 human T291 455824 kFsEQGGtPQNVATS X -CDK1 CDK1 P06493 human CASP8 841 Q14790 CASP8 human S387 16855100 yLEMDLSsPQTRYIP Peptidase_C14 X X -CDK1 CDK1 P06493 human SUN1 iso9 23353 O94901-9 SUN1 human S333 17861021 HTAAHSQsPRLPGRA MRP X X -CDK1 CDK1 P06493 human TFCP2L1 29842 Q9NZI6 TFCP2L1 human T177 38489957 HCISTEFtPRKHGGE CP2 X -CDK1 CDK1 P06493 human kindlin-2 10979 Q96AC1 FERMT2 human S177 4760248 LItPGsGsIyssPGL X X -CDK1 CDK1 P06493 human dUTPase 1854 P33316 DUT human S99 451166 GPEtPAIsPSKRARP X -CDK1 CDK1 P06493 human EGFR 1956 P00533 EGFR human S1026 451640 PQQGFFssPSTsRtP X -CDK1 CDK1 P06493 human MARK2 2011 Q7KZI7 MARK2 human S619 455400 PyGVtPAsPsGHsQG X -CDK1 CDK1 P06493 human PHLPP 23239 O60346 PHLPP1 human S425 23131538 KAPRAIDsPGGAVRE X X -CDK1 CDK1 P06493 human RFA2 6118 P15927 RPA2 human S23 448337 GAGGYtQsPGGFGsP X -CDK1 CDK1 P06493 human ID2 3398 Q02363 ID2 human S5 451265 ___MKAFsPVRSVRk X -CDK1 CDK1 P06493 human IP3R1 16438 P11881 Itpr1 mouse T799 450269 RDPQEQVtPVKYARL X X -CDK1 CDK1 P06493 human PITPNM1 9600 O00562 PITPNM1 human T287 451454 SAASNTGtPDGPEAP X -CDK1 CDK1 P06493 human PEX14 5195 O75381 PEX14 human S232 455420 NRRQFPPsPsAPKIP X -CDK1 CDK1 P06493 human SRC-3 8202 Q9Y6Q9 NCOA3 human S728 3217881 VVkQEQLsPKKKENN DUF4927 X X -CDK1 CDK1 P06493 human NCKAP5L 57701 Q9HCH0 NCKAP5L human S470 31863313 PTSEKsPsPGGPQLs X -CDK1 CDK1 P06493 human DRP1 10059 O00429 DNM1L human S616 454690 PIPIMPAsPQKGHAV X X 3455; 4494; 63940 -CDK1 CDK1 P06493 human RCC1 1104 P18754 RCC1 human S11 452007 KRIAKRRsPPADAIP X 4210; 5500 -CDK1 CDK1 P06493 human JunB 24517 P24898 Junb rat S23 1814002 AAAGYGRsPGSLSLH Jun X X -CDK1 CDK1 P06493 human TAZ 25937 Q9GZV5 WWTR1 human S90 4777166 QHVRsHssPAsLQLG X X -CDK1 CDK1 P06493 human RECQL4 9401 O94761 RECQL4 human S89 25173042 LNRAATKsPQStPGR Drc1-Sld2 X X -CDK1 CDK1 P06493 human PKR 5610 P19525 EIF2AK2 human S456 3181637 KGtLRyMsPEQISSQ Pkinase X -CDK1 CDK1 P06493 human STMN1 29332 P13668 Stmn1 rat S25 448555 QAFELILsPRSKESV Stathmin X -CDK1 CDK1 P06493 human Nlp 22981 Q9Y2I6 NINL human S185 15668109 WDSEDFGsPQKSCsP X -CDK1 CDK1 P06493 human HMGA1 3159 P17096 HMGA1 human T53 451515 kEPsEVPtPkRPrGr X -CDK1 CDK1 P06493 human BAG3 9531 O95817 BAG3 human S289 469169 RsstPLHsPsPIRVH X -CDK1 CDK1 P06493 human EZH2 14056 Q61188 Ezh2 mouse T487 452848 VPTEDVDtPPRKKKR X -CDK1 CDK1 P06493 human CDC7 8317 O00311 CDC7 human T376 2864203 QVAPRAGtPGFRAPE Pkinase X -CDK1 CDK1 P06493 human CDCA5 113130 Q96FF9 CDCA5 human S83 3208977 PRRsPRIsFFLEKEN X X -CDK1 CDK1 P06493 human TPP1 1200 O14773 TPP1 human T201 3963104 VGLHLGVtPSVIRKR X -CDK1 CDK1 P06493 human HuR 1994 Q15717 ELAVL1 human S202 3197192 LLsQLyHsPArrFGG X X -CDK1 CDK1 P06493 human NOLC1 64896 P41777 Nolc1 rat T615 451912 VKLQtPNtFPKRKKG X -CDK1 CDK1 P06493 human JARID1B 10765 Q9UGL1 KDM5B human S1328 15411230 NRTSYLHsPFSTGRS X -CDK1 CDK1 P06493 human AAK1 500244 P0C1X8 Aak1 rat T388 483910 LPIQPALtPRKRATV X -CDK1 CDK1 P06493 human ULK1 22241 O70405 Ulk1 mouse S637 3176158 FDFPKtPssQNLLTL X 14205 -CDK1 CDK1 P06493 human NME1 191575 Q05982 Nme1 rat T94 3180917 GRVMLGEtNPADskP NDK X -CDK1 CDK1 P06493 human SAS6 163786 Q6UVJ0 SASS6 human S510 483310 NTIRsGIsPNLNVVD X X -CDK1 CDK1 P06493 human BAG3 9531 O95817 BAG3 human S291 467532 stPLHsPsPIRVHTV X -CDK1 CDK1 P06493 human CDC27 996 P30260 CDC27 human T329 455857 ARIGQTGtkSVFsQs X -CDK1 CDK1 P06493 human Bcl-2 596 P10415 BCL2 human T69 448398 SRDPVARtsPLQtPA X -CDK1 CDK1 P06493 human Abi-1 10006 Q8IZP0 ABI1 human S216 3205884 VPNDyMtsPARLGsQ X X -CDK1 CDK1 P06493 human MCM2 17216 P97310 Mcm2 mouse S27 452310 IsDPLtssPGRsSRR X X -CDK1 CDK1 P06493 human Caldesmon 373965 P12957 CALD1 chicken S682 448464 EKGNVFSsPGGTGtP Caldesmon X -CDK1 CDK1 P06493 human NONO 53610 Q99K48 Nono mouse T15 18013091 NLEKQNHtPRKHHQH X -CDK1 CDK1 P06493 human INCENP 3619 Q9NQS7 INCENP human T59 458332 EPELMPKtPSQKNRR X -CDK1 CDK1 P06493 human RANBP2 5903 P49792 RANBP2 human S2276 452314 FsFksALsPsKsPAk X -CDK1 CDK1 P06493 human OSBP2 23762 Q969R2 OSBP2 human S768 15721697 HssPssPsSDGKQKT Oxysterol_BP X -CDK1 CDK1 P06493 human TOP1 7150 P11387 TOP1 human S394 2721303 SKDAkVPsPPPGHkW Topoisom_I_N X -CDK1 CDK1 P06493 human EIF4G2 1982 P78344 EIF4G2 human T508 449145 AQPPrtQtPPLGQtP X -CDK1 CDK1 P06493 human TOP2A 7153 P11388 TOP2A human S1354 452240 DFVPsDAsPPKTKts X -CDK1 CDK1 P06493 human Rb 5925 P06400 RB1 human T373 447982 VNVIPPHtPVRTVMN RB_A X -CDK1 CDK1 P06493 human SEPT9 iso2 10801 Q9UHD8-2 SEPTIN9 human T24 469506 EVETPNStPPRRVQT X X -CDK1 CDK1 P06493 human CKAP2 26586 Q8WWK9 CKAP2 human T623 460436 FkELkFLtPVRRsRR CKAP2_C X X -CDK1 CDK1 P06493 human p70S6K 6198 P23443 RPS6KB1 human S434 448356 sFEPKIRsPRRFIGs X -CDK1 CDK1 P06493 human CEP55 55165 Q53EZ4 CEP55 human S428 457629 KVAAsPksPtAALNE X -CDK1 CDK1 P06493 human APC1 64682 Q9H1A4 ANAPC1 human S355 455825 AALsrAHsPALGVHs X -CDK1 CDK1 P06493 human IP3R1 3708 Q14643 ITPR1 human S421 450268 VMLKIGtsPVkEDkE MIR X -CDK1 CDK1 P06493 human BUB1B 701 O60566 BUB1B human S543 4049929 LsEkKNksPPADPPR X -CDK1 CDK1 P06493 human SOD2 6648 P04179 SOD2 human S106 7577901 SIFWTNLsPNGGGEP Sod_Fe_N X X -CDK1 CDK1 P06493 human NUCKS 64709 Q9EPJ0 Nucks1 rat S181 452956 LKATVtPsPVkGKGk X -CDK1 CDK1 P06493 human CDCA5 113130 Q96FF9 CDCA5 human T159 483401 LGsAStstPGRRsCF Sororin X X -CDK1 CDK1 P06493 human WAC 51322 Q9BTA9 WAC human T471 469445 PIkPLIstPPVssQP X X -CDK1 CDK1 P06493 human Tip60 10524 Q92993 KAT5 human S90 448827 LPGsRPGsPEREVPA X X -CDK1 CDK1 P06493 human POLR2A 363633 D4A5A6 Polr2a rat S1920 452274 sPTYsPTsPKySPts RNA_pol_Rpb1_R; RNA_pol_Rpb1_R X -CDK1 CDK1 P06493 human Restin 65201 Q9JK25 Clip1 rat T286 483203 KIGFPSTtPAKAKAA X X -CDK1 CDK1 P06493 human MYST2 11143 O95251 KAT7 human T85 1823700 tRsQQQPtPVtPkKY X -CDK1 CDK1 P06493 human RCC1 1104 P18754 RCC1 human S387 2850006 GQDEDAWsPVEMMGK RCC1 X -CDK1 CDK1 P06493 human CHMP7 91782 Q8WUX9 CHMP7 human S3 54367850 _____MWsPEREAEA X -CDK1 CDK1 P06493 human TERT 7015 O14746 TERT human T249 1868023600 AAPEPERtPVGQGSW X X -CDK1 CDK1 P06493 human TTDN1 136647 Q8TAP9 MPLKIP human S104 478366 sQQQFGYsPGQQQtH MPLKIP X -CDK1 CDK1 P06493 human APC1 64682 Q9H1A4 ANAPC1 human S555 455832 LDEVVLLsPVPELRD X -CDK1 CDK1 P06493 human CDC16 8881 Q13042 CDC16 human T581 455867 TAEETGLtPLETsRK X -CDK1 CDK1 P06493 human BARD1 580 Q99728 BARD1 human S288 467302 PLAEQIEsPDTKSRN X -CDK1 CDK1 P06493 human NSBP1 79366 P82970 HMGN5 human T31 456124 sAMLVPVtPEVkPKR HMG14_17 X -CDK1 CDK1 P06493 human GRP58 29468 P11598 Pdia3 rat S456 3963114 GFPTIyFsPANKKLT Thioredoxin X -CDK1 CDK1 P06493 human KIFC1 3833 Q9BW19 KIFC1 human S6 12667678 __MDPQRsPLLEVKG X -CDK1 CDK1 P06493 human Raptor 57521 Q8N122 RPTOR human T706 11315002 ttEGGsLtPVRDsPC X X -CDK1 CDK1 P06493 human DLG7 9787 Q15398 DLGAP5 human T639 456340 GPsQRLGtPKsVNkA X -CDK1 CDK1 P06493 human PIK4CB 5298 Q9UBF8 PI4KB human S266 457619 PAPDtGLsPsKRTHQ X -CDK1 CDK1 P06493 human TRIM32 22954 Q13049 TRIM32 human S339 3195098 VVAsPRAsPAkQRGP X -CDK1 CDK1 P06493 human RGC32 28984 Q9H4X1 RGCC human T111 7105234 ALLsAtVtPQKAKLG RGCC X -CDK1 CDK1 P06493 human CDC27 996 P30260 CDC27 human S434 455861 LEItkLDssIIsEGk X -CDK1 CDK1 P06493 human Jun 24516 P17325 Jun rat S73 447943 VGLLKLAsPELERLI Jun X 9164; 3270; 8752; 12714; 77955 -CDK1 CDK1 P06493 human CLASP2 23122 O75122 CLASP2 human S1013 4753159 HSMPtHssPRsRDyN X -CDK1 CDK1 P06493 human BORA 79866 Q6PGQ7 BORA human S41 11452210 LHEQtLAsPSVFkST BORA_N X X -CDK1 CDK1 P06493 human Tau iso8 4137 P10636-8 MAPT human T212 447934 tPGsRsRtPsLPtPP X -CDK1 CDK1 P06493 human SIRT1 23411 Q96EB6 SIRT1 human T530 6006905 YLSELPPtPLHVsED X -CDK1 CDK1 P06493 human YAP1 10413 P46937 YAP1 human T143 3190678 AVsPGtLtPtGVVsG X -CDK1 CDK1 P06493 human SUN1 iso9 23353 O94901-9 SUN1 human S48 7101126 KLDPVFDsPRMSRRS X X -CDK1 CDK1 P06493 human CDC25B 994 P30305 CDC25B human S50 20503402 PVRAAASsPVttLtQ X -CDK1 CDK1 P06493 human AR 367 P10275 AR human S83 448714 QQQQQETsPRQQQQQ Androgen_recep X -CDK1 CDK1 P06493 human DLG7 9787 Q15398 DLGAP5 human T329 456337 TYQVtPMtPRsANAF GKAP X -CDK1 CDK1 P06493 human ATR 545 Q13535 ATR human S428 456320 SSNSDGIsPKRRRLs X 2853 -CDK1 CDK1 P06493 human TPX2 22974 Q9ULW0 TPX2 human T72 460008 NLQQAIVtPLkPVDN X X -CDK1 CDK1 P06493 human BRCA1 672 P38398 BRCA1 human S1191 10272402 GELsRsPsPFtHTHL X X -CDK1 CDK1 P06493 human CCNB1 891 P14635 CCNB1 human S128 448815 LVDTAsPsPMETsGC X -CDK1 CDK1 P06493 human PML 5371 P29590 PML human S518 465867 PsTSkAVsPPHLDGP DUF3583 X X -CDK1 CDK1 P06493 human FMNL2 114793 Q96PY5 FMNL2 human S1016 3209661 MEQQDPKsPsHKSKR X X -CDK1 CDK1 P06493 human VHL 7428 P40337 VHL human S80 50792657 QVIFCNrsPRVVLPV VHL X -CDK1 CDK1 P06493 human KI-67 4288 P46013 MKI67 human T1943 23117871 GskRRPQtPKEKAkA KI67R X -CDK1 CDK1 P06493 human POLR2A 363633 D4A5A6 Polr2a rat S1934 452275 sPTYsPTsPKGSTYS X -CDK1 CDK1 P06493 human dynactin 1 1639 Q14203 DCTN1 human S212 15512802 GAVPPLPsPsKEEEG X -CDK1 CDK1 P06493 human MYST2 11143 O95251 KAT7 human T88 468239 QQQPtPVtPkKYPLR X -CDK1 CDK1 P06493 human desmin 13346 P31001 Des mouse S32 466343 sLGsPLssPVFPrAG Filament_head X -CDK1 CDK1 P06493 human FOXM1 2305 Q08050 FOXM1 human T600 478080 EVGGPFKtPIkETLP X 14655 -CDK1 CDK1 P06493 human OSBP2 23762 Q969R2 OSBP2 human S763 31727226 CSKVMHssPssPsSD Oxysterol_BP X -CDK1 CDK1 P06493 human RFC1 5981 P35251 RFC1 human S518 2915402 VQGkRKIsPSKKESE X -CDK1 CDK1 P06493 human CDCA5 113130 Q96FF9 CDCA5 human T151 28750703 RsysRLEtLGsASts Sororin X X -CDK1 CDK1 P06493 human KIF4A 24137 O95239 KIF4A human T1161 459852 FFNPVCAtPNsKILK X X -CDK1 CDK1 P06493 human PTPN2 iso2 5771 P17706-2 PTPN2 human S304 451134 LSPAFDHsPNKIMTE X X -CDK1 CDK1 P06493 human CDCA5 113130 Q96FF9 CDCA5 human S164 9316471 tstPGRRsCFGFEGL Sororin X X -CDK1 CDK1 P06493 human TOB2 10766 Q14106 TOB2 human S254 14161520 PAPQSQLsPNAKEFV PAM2 X -CDK1 CDK1 P06493 human TIAM1 7074 Q13009 TIAM1 human S1466 4727743 SDAVsASsPEKESQQ X X -CDK1 CDK1 P06493 human SAMHD1 25939 Q9Y3Z3 SAMHD1 human T592 468674 DVIAPLItPQkkEWN X X 89930; 87593; 55092; 45205 -CDK1 CDK1 P06493 human SPT5 6829 O00267 SUPT5H human S666 468817 VGGFAPMsPrISsPM X -CDK1 CDK1 P06493 human CREB 1385 P16220 CREB1 human S257 14159739 PGVVMAssPALPTQP X X -CDK1 CDK1 P06493 human YAP1 10413 P46937 YAP1 human S289 3190663 PPPLAPQsPQGGVMG X X -CDK1 CDK1 P06493 human ERK3 5597 Q16659 MAPK6 human S705 13830501 tPSAMkssPQIPHQT X -CDK1 CDK1 P06493 human PBK 55872 Q96KB5 PBK human T9 451735 EGIsNFktPskLsEk X 4941 -CDK1 CDK1 P06493 human FOXO1A 56458 Q9R1E0 Foxo1 mouse S246 471071 EGGkSGksPRRRAAs X -CDK1 CDK1 P06493 human E2F1 1869 Q01094 E2F1 human S337 447869 IVsPPPSsPPSSLTT X -CDK1 CDK1 P06493 human cGAS 115004 Q8N884 CGAS human S305 36128853 MKRkRGGsPAVTLLI Mab-21 X -CDK1 CDK1 P06493 human SMAD2 Q1W668 SMAD2 cow S250 448795 TGsPAELsPTTLsPV X -CDK1 CDK1 P06493 human RAD9A 5883 Q99638 RAD9A human T292 2999204 PQLQAHStPHPDDFA X -CDK1 CDK1 P06493 human Bcl-2 596 P10415 BCL2 human T56 448655 FSSQPGHtPHPAASR X X 2875 -CDK1 CDK1 P06493 human NHERF 9368 O14745 NHERF1 human S302 468296 EELNsQDsPPKQDST EBP50_C X -CDK1 CDK1 P06493 human Calnexin 821 P27824 CANX human S583 449100 EDEILNRsPRNRKPR X -CDK1 CDK1 P06493 human NEDD1 121441 Q8NHV4 NEDD1 human T550 6225645 PPINGsstPNPKIAs X X -CDK1 CDK1 P06493 human PKN1 5585 Q16512 PKN1 human S533 483281 AtGtGTFsPGAsPGs X X -CDK1 CDK1 P06493 human USP14 9097 P54578 USP14 human T235 3192043 sssAsAAtPskkKSL UCH X -CDK1 CDK1 P06493 human GATA2 2624 P23769 GATA2 human T176 40245500 HLFGFPPtPPKEVsP X X -CDK1 CDK1 P06493 human lamin A/C 60374 P48679 Lmna rat S392 452606 ERLRLsPsPTsQRSR X -CDK1 CDK1 P06493 human Exportin-1 7514 O14980 XPO1 human S391 3174716 sPFsTsAsPLLsGsQ X X -CDK1 CDK1 P06493 human Nogo iso2 Q9JK11-2 Rtn4 rat S16 468313 LVSSSTDsPPRPPPA X -CDK1 CDK1 P06493 human TMPO iso6 7112 P42166 TMPO human S424 469953 FQETEFLsPPRkVPR X -CDK1 CDK1 P06493 human p70S6K 83840 P67999 Rps6kb1 rat T444 448358 RFIGsPRtPVsPVKF X 9204 -CDK1 CDK1 P06493 human LIMD1 8994 Q9UGP4 LIMD1 human S424 3214995 VLLDsPssPRVrLPC X X -CDK1 CDK1 P06493 human NME1 4830 P15531 NME1 human S120 450098 GRNIIhGsDsVEsAE NDK X -CDK1 CDK1 P06493 human SCML2 10389 Q9UQR0 SCML2 human S267 3216606 AsQHsMQsPQKTTLI X -CDK1 CDK1 P06493 human KIBRA 23286 Q8IX03 WWC1 human S542 25673102 sPRSsLSsPSPPCsP X X -CDK1 CDK1 P06493 human NDUFA12 55967 Q9UI09 NDUFA12 human T142 33402204 QEWIPPStPYK____ X X -CDK1 CDK1 P06493 human DYN2 1785 P50570 DNM2 human T766 452323 sAssHsPtPQRRPVS X -CDK1 CDK1 P06493 human MAP7 9053 Q14244 MAP7 human S209 460314 ssAtLLNsPDRARRL X -CDK1 CDK1 P06493 human RANBP2 5903 P49792 RANBP2 human S2251 468569 HAsPLAssPVRkNLF X -CDK1 CDK1 P06493 human NPM1 4869 P06748 NPM1 human T219 449023 kDskPsstPRskGQE X -CDK1 CDK1 P06493 human Caldesmon 373965 P12957 CALD1 chicken T711 448468 INEWLTKtPEGNKsP Caldesmon X -CDK1 CDK1 P06493 human SKA3 221150 Q8IX90 SKA3 human T360 459963 ENLLRtPtPPEVTkI X X -CDK1 CDK1 P06493 human CDCA5 113130 Q96FF9 CDCA5 human T115 469416 VPAtPtStPVPNPEA Sororin X X -CDK1 CDK1 P06493 human PTTG2 10744 Q9NZH5 PTTG2 human S165 7322915 LFQLGPPsPVKMPSP Securin X X -CDK1 CDK1 P06493 human CDCA5 113130 Q96FF9 CDCA5 human S75 470993 VEVPAVQsPRRsPRI X X -CDK1 CDK1 P06493 human NUP98 iso2 4928 P52948-2 NUP98 human T653 478067 IAKPIPQtPESAGNK X -CDK1 CDK1 P06493 human Rb 5925 P06400 RB1 human S807 447980 PGGNIyIsPLksPyk Rb_C X 9308; 8974; 4277; 40283; 8957; 8516; 11917; 99274; 41359; 75864; 72443 -CDK1 CDK1 P06493 human SCML2 10389 Q9UQR0 SCML2 human S590 3216624 sPLVGDIsPKssPHE X X -CDK1 CDK1 P06493 human USP24 23358 Q9UPU5 USP24 human S2047 451983 QRVSDQNsPVLPKKS X -CDK1 CDK1 P06493 human WAC 51322 Q9BTA9 WAC human T457 469444 YVsPRIstPQtNTVP X X -CDK1 CDK1 P06493 human CCNE1 898 P24864 CCNE1 human S399 454414 GLLtPPQsGKKQSSG X -CDK1 CDK1 P06493 human NUP98 iso2 4928 P52948-2 NUP98 human S595 470432 LNNsNLFsPVNRDSE X -CDK1 CDK1 P06493 human ULK1 22241 O70405 Ulk1 mouse T635 4699275 PsFDFPKtPssQNLL X -CDK1 CDK1 P06493 human MST2 6788 Q13188 STK3 human S385 4274113 tMKRNAtsPQVQRPs X X -CDK1 CDK1 P06493 human USP24 23358 Q9UPU5 USP24 human S1616 22547101 NsHsPAGsAAIsQQD X -CDK1 CDK1 P06493 human DRP1 114114 O35303 Dnm1l rat S635 454690 PIPIMPAsPQKGHAV X 3455; 4494; 63940 -CDK1 CDK1 P06493 human MEF2C 4208 Q06413 MEF2C human S396 456980 NIkSEPVsPPRDRTT X -CDK1 CDK1 P06493 human CDC14A 8556 Q9UNH5 CDC14A human S549 1216243800 SNGGNLNsPPGPHSA X X -CDK1 CDK1 P06493 human JunB 24517 P24898 Junb rat S186 1814003 YTNLSSYsPASAPSG Jun X X -CDK1 CDK1 P06493 human NCL 4691 P19338 NCL human T707 21697921 HKPQGKKtKFE____ X X -CDK1 CDK1 P06493 human MCM7 4176 P33993 MCM7 human S121 3189844 RDPGMVRsPQNQYPA MCM_N X X -CDK1 CDK1 P06493 human CREB 1385 P16220 CREB1 human S256 3181028 APGVVMAssPALPTQ X X -CDK1 CDK1 P06493 human SAPS2 9701 O75170 PPP6R2 human S771 4764365 ESGPRCSsPVDTECS X -CDK1 CDK1 P06493 human lamin A/C 16905 P48678 Lmna mouse S390 452605 EEERLRLsPsPtsQR X -CDK1 CDK1 P06493 human TNRC15 26058 Q6Y7W6 GIGYF2 human S30 483131 sItsPPLsPALPkYk X -CDK1 CDK1 P06493 human GRASP65 56082 O35254 Gorasp1 rat S277 455582 EQLPGPGsPGHGTAD X -CDK1 CDK1 P06493 human CDC27 996 P30260 CDC27 human T446 455863 EGkIStItPQIQAFN X X -CDK1 CDK1 P06493 human TOP1 7150 P11387 TOP1 human S112 2721302 EKENGFssPPQIkDE X -CDK1 CDK1 P06493 human FLNA 2316 P21333 FLNA human S1459 452266 kCsGPGLsPGMVRAN Filamin X -CDK1 CDK1 P06493 human CDC25C 398119 P30309 cdc25c-b frog S285 448417 NRSRLYRsPsMPEKL M-inducer_phosp X -CDK1 CDK1 P06493 human kindlin-2 10979 Q96AC1 FERMT2 human S180 3208611 PGsGsIyssPGLysk X X -CDK1 CDK1 P06493 human MAP7 293016 NP_001099740 Map7 rat S231 460314 sSATLLNsPDRARRL X -CDK1 CDK1 P06493 human FOXM1 2305 Q08050 FOXM1 human T620 3194573 SkSVLPRtPEsWRLt X -CDK1 CDK1 P06493 human AML1 iso8 861 Q01196-8 RUNX1 human S293 454400 QYLGSIAsPSVHPAt X -CDK1 CDK1 P06493 human PHLPP 23239 O60346 PHLPP1 human S323 31884076 AsPAPsDssPGEPFV X X -CDK1 CDK1 P06493 human Tau iso8 4137 P10636-8 MAPT human T205 447933 ssPGsPGtPGsRsRt X 25377; 43964; 53001; 49561; 20060; 33032; 30505; 20739; 98160 -CDK1 CDK1 P06493 human Borealin 55143 Q53HL2 CDCA8 human S219 460351 YNIsGNGsPLADskE Borealin X -CDK1 CDK1 P06493 human ERK1 iso3 5595 P27361-3 MAPK3 human S343 50703500 PTDEVGQsPAAVGLG X X -CDK1 CDK1 P06493 human MAP4 4134 P27816 MAP4 human T901 2130500 MPsRPsttPFIDKKP X -CDK1 CDK1 P06493 human TOP2A 7153 P11388 TOP2A human S1393 452242 GsVPLsssPPAtHFP X -CDK1 CDK1 P06493 human NPM1 4869 P06748 NPM1 human T237 449560 kQEKtPKtPkGPssV X X -CDK1 CDK1 P06493 human CDC25C 398119 P30309 cdc25c-b frog T138 449911 LPRLLCStPSFKKTS M-inducer_phosp X -CDK1 CDK1 P06493 human APC1 64682 Q9H1A4 ANAPC1 human T701 455835 kkARPsEtGsDDDWE Apc1_MidN X -CDK1 CDK1 P06493 human RANGAP1 19387 P46061 Rangap1 mouse S444 449222 stFLsFPsPEKLLRL RanGAP1_C X -CDK1 CDK1 P06493 human PPP1CA 24668 P62138 Ppp1ca rat T320 448686 NPGGRPItPPRNSAK X -CDK1 CDK1 P06493 human SQSTM1 8878 Q13501 SQSTM1 human S272 454787 RsRLtPVsPEssstE X X 13121 -CDK1 CDK1 P06493 human PHLPP 23239 O60346 PHLPP1 human T451 3952371 APGGLQstPGRSGVT X X -CDK1 CDK1 P06493 human KIBRA 23286 Q8IX03 WWC1 human S931 3205620 IIRsKtFsPGPQSQy X X -CDK1 CDK1 P06493 human APC1 64682 Q9H1A4 ANAPC1 human T530 455829 NtMPRPstPLDGVst X -CDK1 CDK1 P06493 human HMGA1 iso2 3159 P17096-2 HMGA1 human T42 451515 kEPsEVPtPkrPrGr X -CDK1 CDK1 P06493 human BORA 79866 Q6PGQ7 BORA human S112 27444813 TkDVIVPsPWTDHEG BORA_N X X -CDK1 CDK1 P06493 human KIF11 3832 P52732 KIF11 human T926 448410 LDIPtGttPQRksyL Microtub_bind X -CDK1 CDK1 P06493 human lamin A/C 4000 P02545 LMNA human S392 452606 ErLRLsPsPtsQRsR X -CDK1 CDK1 P06493 human HJURP 55355 Q8NCD3 HJURP human S412 453537 RTLkWLIsPVkIVSR HJURP_C X -CDK1 CDK1 P06493 human 53BP1 7158 Q12888 TP53BP1 human T1609 486510 LGPyEAVtPLtkAAD X -CDK1 CDK1 P06493 human HMGA2 15364 P52927 Hmga2 mouse S44 4033091 QEPTCEPsPKRPRGR X -CDK1 CDK1 P06493 human CDT1 81620 Q9H211 CDT1 human T406 21440503 LPAtPPAtPPAAsPs X X -CDK1 CDK1 P06493 human PPP1R13L 10848 Q8WUF5 PPP1R13L human S84 5197296 EPFGsrGsPRkAAtD X -CDK1 CDK1 P06493 human Rb 5925 P06400 RB1 human S811 448717 IyIsPLksPykIsEG Rb_C X 9308; 8974; 4277; 40283; 8957; 8516; 11917; 41359; 75864; 63276 -CDK1 CDK1 P06493 human EZH2 2146 Q15910 EZH2 human T345 4957354 LtAERIKtPPkRPGG X X 45153 -CDK1 CDK1 P06493 human NCAPG 64151 Q9BPX3 NCAPG human T332 5014904 LIPVETLtPEIALYW X -CDK1 CDK1 P06493 human p300 2033 Q09472 EP300 human S2039 31828207 GLGQVGIsPLKPGTV Creb_binding X X -CDK1 CDK1 P06493 human hnRNP K 3190 P61978 HNRNPK human S216 450148 ILDLIsEsPIkGRAQ X -CDK1 CDK1 P06493 human LATS1 9113 O95835 LATS1 human S613 457596 EKKQITtsPItVRKN X X -CDK1 CDK1 P06493 human Tau iso8 4137 P10636-8 MAPT human S235 449080 VVRtPPKsPssAKsR X 20473 -CDK1 CDK1 P06493 human K8 3856 P05787 KRT8 human S432 448540 sAyGGLtsPGLsysL X X -CDK1 CDK1 P06493 human ADD1 118 P35611 ADD1 human S355 456832 kYKAKsRsPGsPVGE X -CDK1 CDK1 P06493 human ZC3H11A 9877 O75152 ZC3H11A human T321 3175981 PETNIDKtPKKAQVs X -CDK1 CDK1 P06493 human KIF20A 10112 O95235 KIF20A human S21 4921068 sDDDVVVsPMFESTA X -CDK1 CDK1 P06493 human NDUFB6 4712 O95139 NDUFB6 human S55 33402203 NkFLENksPWRKMVH NDUF_B6 X X -CDK1 CDK1 P06493 human p300 2033 Q09472 EP300 human S1038 10941006 STSATQssPAPGQsk X X -CDK1 CDK1 P06493 human TOP2A 7153 P11388 TOP2A human S1213 452237 QMAEVLPsPRGQRVI X -CDK1 CDK1 P06493 human CLASP2 23122 O75122 CLASP2 human S541 24976300 REssRDTsPVRSFQP X -CDK1 CDK1 P06493 human YAP1 10413 P46937 YAP1 human S138 485036 sLQLGAVsPGtLtPt X -CDK1 CDK1 P06493 human Jun 24516 P17325 Jun rat S246 450451 PGETPPLsPIDMESQ X 2994 -CDK1 CDK1 P06493 human SIRT1 23411 Q96EB6 SIRT1 human S540 4770118 HVsEDsssPERtsPP X -CDK1 CDK1 P06493 human SIRT2 22933 Q8IXJ6 SIRT2 human S368 482809 PNPsTsAsPKKsPPP X X -CDK1 CDK1 P06493 human NME2 83782 P19804 Nme2 rat S120 4714197 GRNIIHGsDSVEsAE NDK X -CDK1 CDK1 P06493 human NANOG 79923 Q9H9S0 NANOG human S71 31960307 DsPDsStsPKGKQPt X -CDK1 CDK1 P06493 human SLX4 84464 Q8IY92 SLX4 human T1561 1880104208 LPPKVPItPMPQYSI X -CDK1 CDK1 P06493 human JunB 24517 P24898 Junb rat T150 1814004 LHKMNHVtPPNVSLG Jun X X -CDK1 CDK1 P06493 human NHERF 9368 O14745 NHERF1 human S280 470168 LAEAALEsPRPALVR EBP50_C X -CDK1 CDK1 P06493 human gephyrin 64845 Q03555 Gphn rat S283 2020113 LSttPsEsPRAQAts X -CDK1 CDK1 P06493 human ULK1 22241 O70405 Ulk1 mouse S983 1869357209 TAERLILsHAVQMVQ DUF3543 X -CDK1 CDK1 P06493 human EEF1D iso2 1936 P29692-2 EEF1D human S499 455672 APQTQHVsPMRQVEP X -CDK1 CDK1 P06493 human BORA 79866 Q6PGQ7 BORA human S137 9320596 CTNINsDsPVGKkLT BORA_N X X -CDK1 CDK1 P06493 human CDCA5 113130 Q96FF9 CDCA5 human S79 470691 AVQsPRRsPRIsFFL X X -CDK1 CDK1 P06493 human TREX1 22040 Q91XB0 Trex1 mouse S261 2579810 PLATANGsPSNGRSR X -CDK1 CDK1 P06493 human p53 7157 P04637 TP53 human S315 447530 LPNNtsssPQPkkkP X X 2528 -CDK1 CDK1 P06493 human MAP4 4134 P27816 MAP4 human T892 2130502 VPSRVKAtPMPsRPs X -CDK1 CDK1 P06493 human CDC27 996 P30260 CDC27 human S426 455859 TQPNINDsLEItkLD X -CDK1 CDK1 P06493 human WAC 51322 Q9BTA9 WAC human T244 36128588 AETHSSStPVQHPIK X X -CDK1 CDK1 P06493 human NEK9 91754 Q8TD19 NEK9 human T210 451116 SEYsMAEtLVGtPYY Pkinase X -CDK1 CDK1 P06493 human MAP4 4134 P27816 MAP4 human S787 448480 KAPEkRAsPsKPAsA X X -CDK1 CDK1 P06493 human APLP2 334 Q06481 APLP2 human T736 451599 VEVDPMLtPEERHLN APP_amyloid X -CDK1 CDK1 P06493 human cGAS 214763 Q8C6L5 Cgas mouse S291 36128853 VEKEKPGsPAVTLLI Mab-21 X -CDK1 CDK1 P06493 human MCM3 17215 P25206 Mcm3 mouse S112 2840507 SFGSKHVsPRTLTSC MCM_OB X 12686 -CDK1 CDK1 P06493 human palladin 23022 Q8WX93 PALLD human S641 3207888 PtPAVLLsPTKEPPP X -CDK1 CDK1 P06493 human H1E 3008 P10412 H1-4 human T18 467971 APAPAEktPVkKKAR X -CDK1 CDK1 P06493 human MAN1A1 4121 P33908 MAN1A1 human S12 15411997 GLLPLFSsPAGGVLG X X -CDK1 CDK1 P06493 human Vimentin 7431 P08670 VIM human S56 451514 srsLyAssPGGVyAt Filament_head X 3877; 7391 -CDK1 CDK1 P06493 human AR 367 P10275 AR human S516 452166 VSRVPYPsPTCVkSE X -CDK1 CDK1 P06493 human Akt1 207 P31749 AKT1 human T308 447856 kDGAtMKtFCGtPEy Pkinase X 5106; 2965; 9275; 4056; 5056; 13842; 13038; 43506; 48646; 86758; 80722; 77440; 80556 -CDK1 CDK1 P06493 human EFHD2 298609 Q4FZY0 Efhd2 rat S73 478224 QGIGEPQsPSRRVFN X -CDK1 CDK1 P06493 human NANOG 79923 Q9H9S0 NANOG human S65 31960311 MDLLIQDsPDsStsP X -CDK1 CDK1 P06493 human FLNA 2316 P21333 FLNA human S1436 478363 GGHQVPGsPFKVPVH Filamin X -CDK1 CDK1 P06493 human AKAP12 9590 Q02952 AKAP12 human T767 3801512 EsFkRLVtPRKksKS WSK X X -CDK1 CDK1 P06493 human Chk1 12649 O35280 Chek1 mouse S301 465528 IHsNLDFsPVNNGSs X -PRKG1 PKG1 iso2 Q13976-2 human CRIP2 338401 P36201 Crip2 rat S104 3141905 RTEERKTsGPPKGPS X -PRKG1 PKG1 iso2 Q13976-2 human HSP27 3315 P04792 HSPB1 human T143 471871 RCFtRkytLPPGVDP HSP20 X -PRKG1 PKG1 iso2 Q13976-2 human HSP27 3315 P04792 HSPB1 human S15 448401 FsLLrGPsWDPFrDW X 2404 -PRKG1 PKG1 iso2 Q13976-2 human PKG1 iso2 5592 Q13976-2 PRKG1 human S65 2864204 TQQAQKQsASTLQGE X -PRKG1 PKG1 iso2 Q13976-2 human HSP27 3315 P04792 HSPB1 human S82 448403 RALsRQLssGVsEIr X 2406; 2401; 9709; 11892; 64293 -PRKG1 PKG1 iso2 Q13976-2 human HSP27 3315 P04792 HSPB1 human S78 448402 PAysRALsRQLssGV X 2405 -PRKG1 PKG1 iso2 Q13976-2 human PKG1 iso2 5592 Q13976-2 PRKG1 human S81 452147 RtKRQAIsAEPTAFD X -PRKG1 PKG1 iso2 Q13976-2 human PAK1 5058 Q13153 PAK1 human S21 448174 APPMRNtsTMIGAGs X -PRKG1 PKG1 iso2 Q13976-2 human Lasp-1 3927 Q14847 LASP1 human S146 448836 MEPERRDsQDGssyR X X -Tnk2 Ack O54967 mouse Akt1 11651 P31750 Akt1 mouse Y176 14515900 EKATGRYyAMKILKK Pkinase X X -Pim1 Pim1 P06803 mouse BAD 12015 Q61337 Bad mouse S112 447860 ETRsRHssyPAGtEE Bcl-2_BAD X X 9291; 5284; 9296; 5193; 11865; 94223 -Pim1 Pim1 P06803 mouse NOTCH3 18131 Q61982 Notch3 mouse S1673 11179168 ARRKREHsTLWFPEG X X -Pim1 Pim1 P06803 mouse BAD 12015 Q61337 Bad mouse S136 447862 PFRGRsRsAPPNLWA Bcl-2_BAD X 9295; 5286; 4366 -KSR1 KSR Q8IVT5 human RAF1 5894 P04049 RAF1 human T269 447747 NVHMVsttLPVDSRM X X -STK33 STK33 Q9BYT3 human STK33 65975 Q9BYT3 STK33 human T382 25755119 LLDNQWLtGNkLSSV X X -SIK3 QSK Q9Y2K2 human TORC3 70461 Q91X84 Crtc3 mouse S162 7101661 SALNRTNsDSALHTS TORC_M X -SIK3 QSK Q9Y2K2 human TORC3 70461 Q91X84 Crtc3 mouse S370 1210886 SLRLFsLsNPsLSTT X -SIK3 QSK Q9Y2K2 human TORC3 70461 Q91X84 Crtc3 mouse S62 3203139 LtQyHGGsLPNVSQL TORC_N X -SIK3 QSK Q9Y2K2 human HDAC4 208727 Q6NZM9 Hdac4 mouse S245 448488 FPLRKTAsEPNLKLR X 3443 -SIK3 QSK Q9Y2K2 human TORC3 70461 Q91X84 Crtc3 mouse S329 468980 SGLQSsRsNPsIQAT X -PAK4 PAK4 O96013 human NRF2 4780 Q16236 NFE2L2 human T369 1876350200 ESSSYGDtLLGLsDs X X -PAK4 PAK4 O96013 human CTNNB1 1499 P35222 CTNNB1 human S675 457120 QDykKRLsVELtsSL X X 9567; 4176; 68076 -PAK4 PAK4 O96013 human Snail2 6591 O43623 SNAI2 human S254 63243402 sKTFsRMsLLHKHEE zf-C2H2 X X -PAK4 PAK4 O96013 human N-WASP 8976 O00401 WASL human S484 3149548 KRSKAIHssDEDEDE X -PAK4 PAK4 O96013 human PXN iso2 5829 P49023-2 PXN human S272 465466 ELDELMAsLSDFKFM X X -PAK4 PAK4 O96013 human MZF-1 7593 P28698 MZF1 human S27 50784428 VMVkLEDsEEEGEAA X -PAK4 PAK4 O96013 human LIMK2 3985 P53671 LIMK2 human T505 448683 NDRKKRYtVVGNPYW PK_Tyr_Ser-Thr X 3841 -PAK4 PAK4 O96013 human ARHGEF2 iso2 9181 Q92974-2 ARHGEF2 human S885 451365 PVDPRRRsLPAGDAL X 14143 -PAK4 PAK4 O96013 human TORC1 684527 Q157S1 Crtc1 rat S215 60885604 KAGSRPKsCEVPGIN TORC_M X -PAK4 PAK4 O96013 human CTNNB1 12387 Q02248 Ctnnb1 mouse S675 457120 QDykKRLsVELtSsL X X 9567; 4176; 68076 -PAK4 PAK4 O96013 human STMN2 11075 Q93045 STMN2 human S50 455606 KQINKRAsGQAFELI Stathmin X X -PAK4 PAK4 O96013 human ICAP1 9270 O14713 ITGB1BP1 human S10 1872961000 RKGKKRHssSsSQSS ICAP-1_inte_bdg X X -PAK4 PAK4 O96013 human Snail2 6591 O43623 SNAI2 human S158 1162843400 CDAQSRKsFSCKYCD X X -PAK4 PAK4 O96013 human PAK4 10298 O96013 PAK4 human S474 448023 kEVPRRksLVGtPyW Pkinase X X 3241 -PAK4 PAK4 O96013 human LIMK1 16885 P53668 Limk1 mouse T508 447808 PDRKKRYtVVGNPYW PK_Tyr_Ser-Thr X 3841 -PAK4 PAK4 O96013 human AML1 861 Q01196 RUNX1 human T207 34551130 ELEQLRrtAMrVsPH X -PAK4 PAK4 O96013 human ITGB5 3693 P18084 ITGB5 human S759 14694704 REFAkFQsERsRARy Integrin_b_cyt X X -PAK4 PAK4 O96013 human N-WASP 8976 O00401 WASL human S485 3149547 RSKAIHssDEDEDED X -PAK4 PAK4 O96013 human ITGB5 3693 P18084 ITGB5 human S762 14694703 AkFQsERsRARyEMA Integrin_b_cyt X X -PAK4 PAK4 O96013 human fumarase 2271 P07954 FH human S46 36132325 PNAARMAsQNSFRIE X X -PAK4 PAK4 O96013 human TH 7054 P07101 TH human S71 448545 RFIGRRQsLIEDARK TOH_N X X 2791 -PAK4 PAK4 O96013 human Akt1 11651 P31750 Akt1 mouse S473 447855 RPHFPQFsysAsGtA Pkinase_C X X 9271; 3787; 4060; 4051; 5102; 4058; 2336; 2337; 4075; 4070; 5012; 4071; 92982; 5315; 9563; 9018; 12694; 52240; 11962; 15116; 88106; 26580; 68035; 31957; 23430; 20235 -PAK4 PAK4 O96013 human RAN 5901 P62826 RAN human S135 469112 DRkVKAksIVFHRkk Ras X X -PAK4 PAK4 O96013 human p53 7157 P04637 TP53 human S215 454242 DrNtFrHsVVVPyEP P53 X X -PAK4 PAK4 O96013 human LIMK1 3984 P53667 LIMK1 human T508 447808 PDRKKRYtVVGNPYW PK_Tyr_Ser-Thr X X 3841 -PAK4 PAK4 O96013 human ER-alpha 2099 P03372 ESR1 human S305 448805 IkRSkkNsLALSLtA X -Mark2 MARK2 O08679 rat Tau iso8 4137 P10636-8 MAPT human S262 447930 NVKskIGstENLkHQ Tubulin-binding X X -Mark2 MARK2 O08679 rat Tau iso8 4137 P10636-8 MAPT human S324 449328 kVtskCGsLGNIHHk Tubulin-binding X -Mark2 MARK2 O08679 rat Tau iso8 4137 P10636-8 MAPT human S293 449327 NVQskCGsKDNIkHV Tubulin-binding X -Mark2 MARK2 O08679 rat Tau iso8 4137 P10636-8 MAPT human S356 449104 rVQskIGsLDNItHV Tubulin-binding X -Mark2 MARK2 O08679 rat Tau 29477 P19332 Mapt rat S573 447930 NVRSKIGsTENLKHQ Tubulin-binding X -MYLK2 skMLCK Q9H1R3 human MEF2C 4208 Q06413 MEF2C human T80 19083402 NEPHESRtNsDIVEt X -Ntrk2 TrkB Q63604 rat TrkB 25054 Q63604 Ntrk2 rat Y706 448812 DVyStDyyRVGGHTM PK_Tyr_Ser-Thr X X 4621 -Ntrk2 TrkB Q63604 rat PLCG1 25738 P10686 Plcg1 rat Y1253 448576 EGsFEARyQQPFEDF X -Ntrk2 TrkB Q63604 rat TrkB 25054 Q63604 Ntrk2 rat Y701 451661 FGMSRDVyStDyyRV PK_Tyr_Ser-Thr X X -Ntrk2 TrkB Q63604 rat TrkB 25054 Q63604 Ntrk2 rat Y816 451754 LAkAsPVyLDILG__ X 4168 -Ntrk2 TrkB Q63604 rat TrkB 25054 Q63604 Ntrk2 rat Y705 448811 RDVyStDyyRVGGHT PK_Tyr_Ser-Thr X X 4621 -Ntrk2 TrkB Q63604 rat PLCG1 25738 P10686 Plcg1 rat Y783 447667 EGRNPGFyVEANPMP X 2821; 14461; 14008; 25678; 88717 -Ntrk2 TrkB Q63604 rat NCAM1 17967 P13595 Ncam1 mouse Y734 454070 VVMDITCyFLNKCGL X -Ntrk2 TrkB Q63604 rat TrkB 25054 Q63604 Ntrk2 rat Y515 448813 PVIENPQyFGITNSQ X X 4619 -Ntrk2 TrkB Q63604 rat NCAM1 24586 P13596 Ncam1 rat Y744 454070 VVMDITCyFLNKCGL X -Hipk1 HIPK1 O88904 mouse DAXX 13163 O35613 Daxx mouse S669 7249306 TsVQPMPsPPLAsVA X -Mapkapk5 MAPKAPK5 O54992 mouse WNK4 65266 Q96J92 WNK4 human S575 53332700 PFLFRHAsYSSTTSD X -Mapkapk5 MAPKAPK5 O54992 mouse RHEB 6009 Q15382 RHEB human S130 18157800 LHMERVIsYEEGkAL Ras X -Mapkapk5 MAPKAPK5 O54992 mouse PLA2G4A 18783 P47713 Pla2g4a mouse S726 447599 RQNPsRCsVsLsNVE X -Abl1 Abl P00520 mouse RAPH1 65059 Q70E73 RAPH1 human Y426 465028 LLRAsGIyYVPKGKA PH X -Abl1 Abl P00520 mouse RAPH1 77300 G5E867 Raph1 mouse Y479 465028 LLRAsGIyYVPKGKA PH X -Abl1 Abl P00520 mouse hnRNP P2 233908 P56959 Fus mouse Y518 50318713 QDRRERPy_______ X -Abl1 Abl P00520 mouse BMPR1A 12166 P36895 Bmpr1a mouse Y458 25655002 EEyQLPyyNMVPSDP PK_Tyr_Ser-Thr X -Abl1 Abl P00520 mouse PLSCR1 5359 O15162 PLSCR1 human Y69 2915403 PVPNQPVyNQPVyNQ X -Abl1 Abl P00520 mouse RAPH1 65059 Q70E73 RAPH1 human Y456 26348502 NVYYGQDyRNKYKAP PH X -Abl1 Abl P00520 mouse APP iso4 351 P05067-4 APP human Y682 448202 sKMQQNGyENPTyKF APP_amyloid X -Abl1 Abl P00520 mouse ZAP70 22637 P43404 Zap70 mouse Y318 447587 TSVyESPySDPEELK X 2701; 2717; 14791; 73382; 82975; 31754 -Abl1 Abl P00520 mouse CDV-3 321022 Q4VAA2 Cdv3 mouse Y120 450290 FEQREVDySGLRVQA CDV3 X -Abl1 Abl P00520 mouse BMPR1A 12166 P36895 Bmpr1a mouse Y453 3712679 TGGIVEEyQLPyyNM PK_Tyr_Ser-Thr X -Abl1 Abl P00520 mouse RAPH1 65059 Q70E73 RAPH1 human Y1226 458696 GGSHIsGyAtLRRGP X -Abl1 Abl P00520 mouse p27Kip1 1027 P46527 CDKN1B human Y88 456818 kGsLPEFyyRPPRPP X X -Abl1 Abl P00520 mouse Abl 11350 P00520 Abl1 mouse Y393 450298 RLMTGDTytAHAGAK PK_Tyr_Ser-Thr X 2865 -Abl1 Abl P00520 mouse Fe65 11785 Q9QXJ1 Apbb1 mouse Y547 451143 VQKFQVYyLGNVPVA PID X X -Abl1 Abl P00520 mouse CBL 867 P22681 CBL human Y774 448531 sENEDDGyDVPKPPV X 3555 -Abl1 Abl P00520 mouse Mena iso3 13800 Q03173-3 Enah mouse Y296 449088 PLPSGPAyASALPPP X -Abl1 Abl P00520 mouse BMPR1A 12166 P36895 Bmpr1a mouse Y457 25655000 VEEyQLPyyNMVPSD PK_Tyr_Ser-Thr X -Abl1 Abl P00520 mouse PARP1 iso3 11545 Q3TF18 Parp1 mouse Y829 1869121001 HATTHNAyDLEVIDI PARP X -Abl1 Abl P00520 mouse Abl 11350 P00520 Abl1 mouse Y226 450303 KRNKPTIyGVSPNyD X 2868; 2861 -Abl1 Abl P00520 mouse BMPR1A 12166 P36895 Bmpr1a mouse Y467 25655001 MVPSDPSyEDMREVV PK_Tyr_Ser-Thr X -Abl1 Abl P00520 mouse PKCD 18753 P28867 Prkcd mouse Y311 447573 TTEsVGIyQGFEKKP X 2055 -Abl1 Abl P00520 mouse CBL 867 P22681 CBL human Y700 448529 EGEEDtEyMtPssRP X 8869 -Abl1 Abl P00520 mouse DOK1 13448 P97465 Dok1 mouse Y361 448367 DsKEDPIyDEPEGLA X X -Abl1 Abl P00520 mouse RAPH1 iso4 77300 F2Z3U3 Raph1 mouse Y1242 458696 GGSHISGyATLRRGP X -Abl1 Abl P00520 mouse PLSCR1 5359 O15162 PLSCR1 human Y74 464050 PVyNQPVyNQPVGAA X -Abl1 Abl P00520 mouse Cortactin 13043 Q60598 Cttn mouse Y466 447703 TyTSEPVyETTEAPG X -Abl1 Abl P00520 mouse DGCR8 54487 Q8WYQ5 DGCR8 human Y267 479394 KRRTEEKyGGDsDHP X -Abl1 Abl P00520 mouse CDK5 12568 P49615 Cdk5 mouse Y15 448022 EkIGEGtyGtVFKAK Pkinase X 94254; 19051 -Abl1 Abl P00520 mouse Doublecortin 13193 O88809 Dcx mouse Y125 1833062501 ELEEGESyVCSSDNF DCX X -Abl1 Abl P00520 mouse UBE3A iso2 7337 Q05086-2 UBE3A human Y636 50838700 GDSHPVLyQSLKDLL HECT X X -Abl1 Abl P00520 mouse DGKA 397097 P20192 DGKA pig Y217 22874703 KRFPRPVyCNLCESS C1_1 X X -Abl1 Abl P00520 mouse RAPH1 65059 Q70E73 RAPH1 human Y513 477344 GKQLyMNyQEALKRT X -Abl1 Abl P00520 mouse WAVE2 242687 Q8BH43 Wasf2 mouse Y150 455197 GKEALKFyTNPSyFF X -Erbb2 HER2 P70424 mouse YAP1 22601 P46938 Yap1 mouse S112 448847 PQHVRAHssPAsLQL X 4911; 13008; 92367; 57706 -Erbb2 HER2 P70424 mouse YAP1 22601 P46938 Yap1 mouse S94 452305 KsHsRQAstDAGtAG X 46931; 53749 -Csnk1a1 CK1A P97633 rat AQP2 359 P41181 AQP2 human S256 449854 REVRRRQsVELHsPQ X -Csnk1a1 CK1A P97633 rat CTNNB1 1499 P35222 CTNNB1 human S45 447488 GATtTAPsLsGkGNP X 9565; 9564; 24710; 70034; 19807; 96727; 77605 -Csnk1a1 CK1A P97633 rat NFAT4 4775 Q12968 NFATC3 human S180 3081705 RSWFsDAssCEsLsH X -Csnk1a1 CK1A P97633 rat GRP94 7184 P14625 HSP90B1 human S347 3082300 kPIWQRPskEVEEDE HSP90 X -Csnk1a1 CK1A P97633 rat galectin-3 3958 P17931 LGALS3 human S6 450131 __MADNFsLHDALsG X -Csnk1a1 CK1A P97633 rat NFAT4 4775 Q12968 NFATC3 human S177 3081701 ISsRSWFsDAssCEs X -Csnk1a1 CK1A P97633 rat FADD 8772 Q13158 FADD human S194 447653 QNRsGAMsPMsWNsD X 2781 -Csnk1a1 CK1A P97633 rat NFAT4 4775 Q12968 NFATC3 human S165 448858 RESSLsPsPASSISs X -Csnk1a1 CK1A P97633 rat PRH 5555 P02810 PRH2 human S38 451071 VIsDGGDsEQFIDEE Pro-rich X -Csnk1a1 CK1A P97633 rat PRH 5555 P02810 PRH2 human S24 451070 QDLDEDVsQEDVPLV Pro-rich X -Csnk1a1 CK1A P97633 rat CSN2 281099 P02666 CSN2 cow S50 467292 KKIEKFQsEEQQQTE X -Csnk1a1 CK1A P97633 rat NFAT4 4775 Q12968 NFATC3 human S186 3081704 AssCEsLsHIYDDVD X -Csnk1a1 CK1A P97633 rat EIF4B 300253 Q5RKG9 Eif4b rat S504 452271 ssDtEQPsPTSGGGK X -Csnk1a1 CK1A P97633 rat NFAT4 4775 Q12968 NFATC3 human S181 3081702 SWFsDAssCEsLsHI X -Csnk1a1 CK1A P97633 rat NFAT4 4775 Q12968 NFATC3 human S184 3081703 sDAssCEsLsHIYDD X -CHEK2 Chk2 O96017 human MBP 618684 P02687 MBP cow T64 487423 DGHHAARtTHYGSLP Myelin_MBP X -CHEK2 Chk2 O96017 human SIAH2 6478 O43255 SIAH2 human S68 5393502 GGGAGPVsPQHHELT X -CHEK2 Chk2 O96017 human BRCA1 12189 P48754 Brca1 mouse S971 448526 QSVSPIRsSIKTDNR X -CHEK2 Chk2 O96017 human p53 7157 P04637 TP53 human S37 447532 NVLsPLPsQAMDDLM TAD2 X 9289 -CHEK2 Chk2 O96017 human Chk2 11200 O96017 CHEK2 human S33 447549 tQsQGSSsQsQGIss X 2665 -CHEK2 Chk2 O96017 human Chk2 11200 O96017 CHEK2 human S435 2811404 SEHRtQVsLkDQITS Pkinase X -CHEK2 Chk2 O96017 human TTK 7272 P33981 TTK human T288 6370307 sPDCDVktDDsVVPC X X -CHEK2 Chk2 O96017 human AATF 26574 Q9NY61 AATF human S510 3753302 KKVDRKAsKGRKLRF TRAUB X -CHEK2 Chk2 O96017 human SIAH2 6478 O43255 SIAH2 human T119 26371004 PTCRGALtPSIRNLA X -CHEK2 Chk2 O96017 human AurB 9212 Q96GD4 AURKB human S331 22259700 HPWVRANsRRVLPPS X -CHEK2 Chk2 O96017 human IRTKS 55971 Q9UHR4 BAIAP2L1 human S331 2509171 PSLQRsVsVAtGLNM X -CHEK2 Chk2 O96017 human LATS2 26524 Q9NRM7 LATS2 human S446 17600401 HILHPVKsVRVLRPE X -CHEK2 Chk2 O96017 human p53 7157 P04637 TP53 human T18 447541 EPPLsQEtFsDLWkL P53_TAD X 2529 -CHEK2 Chk2 O96017 human HuR 1994 Q15717 ELAVL1 human T118 474554 sGLPRTMtQkDVEDM RRM_1 X X -CHEK2 Chk2 O96017 human PML iso3 5371 P29590-3 PML human S117 455494 ESLQRRLsVYRQIVD X X -CHEK2 Chk2 O96017 human LATS2 26524 Q9NRM7 LATS2 human S408 17600400 PVPSRTNsFNSHQPR X -CHEK2 Chk2 O96017 human beclin 1 8678 Q14457 BECN1 human S93 5473540 ARMMstEsANsFTLI X X 14717 -CHEK2 Chk2 O96017 human MBP 618684 P02687 MBP cow T33 451756 FLPRHRDtGILDSLG Myelin_MBP X -CHEK2 Chk2 O96017 human AATF 26574 Q9NY61 AATF human S143 3753301 SKKSRSHsAktPGFs X -CHEK2 Chk2 O96017 human E2F1 1869 Q01094 E2F1 human S364 449403 PLLSRMGsLRAPVDE X X -CHEK2 Chk2 O96017 human Tau iso8 4137 P10636-8 MAPT human S262 447930 NVKskIGstENLkHQ Tubulin-binding X X -CHEK2 Chk2 O96017 human H1C 3006 P16403 H1-2 human T92 487416 ksLVskGtLVQTkGt Linker_histone X -CHEK2 Chk2 O96017 human BRCA1 672 P38398 BRCA1 human S988 448526 PPLFPIksFVKTKCK X X -CHEK2 Chk2 O96017 human VHL 7428 P40337 VHL human S111 22516600 GtGRRIHsyRGHLWL VHL X X -CHEK2 Chk2 O96017 human H1C 3006 P16403 H1-2 human S55 487418 VAAskErsGVsLAAL Linker_histone X -CHEK2 Chk2 O96017 human LATS2 26524 Q9NRM7 LATS2 human S380 3213669 ATLARRDsLQKPGLE X -CHEK2 Chk2 O96017 human XRCC1 7515 P18887 XRCC1 human S210 5014906 AsDPAGPsyAAATLQ X -CHEK2 Chk2 O96017 human Chk2 11200 O96017 CHEK2 human S19 447546 sHGsSACsQPHGsVt X 2666 -CHEK2 Chk2 O96017 human perilipin 3 10226 O60664 PLIN3 human Y251 1873650102 ErLRQHAyEHSLGkL Perilipin X X -CHEK2 Chk2 O96017 human H1C 3006 P16403 H1-2 human T167 487415 kPAAAtVtkkVAKsP X -CHEK2 Chk2 O96017 human MBP 618684 P02687 MBP cow S150 487420 HDAQGtLsKIFKLGG Myelin_MBP X -CHEK2 Chk2 O96017 human XRCC1 7515 P18887 XRCC1 human T284 5014905 APtRtPAtAPVPARA X X -CHEK2 Chk2 O96017 human CDC25C 995 P30307 CDC25C human S216 448418 sGLyRsPsMPENLNR M-inducer_phosp X 9528; 4901; 30790 -CHEK2 Chk2 O96017 human perilipin 2 123 Q99541 PLIN2 human Y232 1873650100 TkLHSRAyQQALsRV Perilipin X X -CHEK2 Chk2 O96017 human Rb 5925 P06400 RB1 human S612 447977 MyLsPVRsPKKKGsT X X -CHEK2 Chk2 O96017 human CDC25A 993 P30304 CDC25A human S279 449129 VLKRPErsQEEsPPG M-inducer_phosp X -CHEK2 Chk2 O96017 human MBP 618684 P02687 MBP cow S17 487422 sKYLASAstMDHARH Myelin_MBP X -CHEK2 Chk2 O96017 human REV3 5980 O60673 REV3L human S1075 3363400 ENIKRTLsFRKKRSH DUF4683 X -CHEK2 Chk2 O96017 human beclin 1 8678 Q14457 BECN1 human S90 472001 IPPARMMstEsANsF X X 29362; 86455 -CHEK2 Chk2 O96017 human TIF1B 21849 Q62318 Trim28 mouse S473 452391 SGMkRsRsGEGEVSG X -CHEK2 Chk2 O96017 human MDM4 4194 O15151 MDM4 human S367 457676 PDCRRtIsAPVVRPk X X -CHEK2 Chk2 O96017 human p53 7157 P04637 TP53 human S366 455223 PGGsRAHssHLkskk X X -CHEK2 Chk2 O96017 human E2F3 1871 O00716 E2F3 human S124 11929101 PALGrGGsGGGGGPP X -CHEK2 Chk2 O96017 human Chk2 11200 O96017 CHEK2 human S260 447554 KRKFAIGsAREADPA Pkinase X -CHEK2 Chk2 O96017 human SIAH2 6478 O43255 SIAH2 human T26 5393503 PPPQPQHtPsPAAPP X -CHEK2 Chk2 O96017 human FOXM1 iso2 2305 Q08050-2 FOXM1 human S361 471396 PLLPRVSsYLVPIQF X X -CHEK2 Chk2 O96017 human XRCC1 7515 P18887 XRCC1 human S184 5014907 EEDESANsLRPGALF X -CHEK2 Chk2 O96017 human CDC25A 993 P30304 CDC25A human S124 449127 PALkRSHsDsLDHDI M-inducer_phosp X X -CHEK2 Chk2 O96017 human INCENP 3619 Q9NQS7 INCENP human S91 4273495 RRLSRRKsRssQLsS X X -CHEK2 Chk2 O96017 human Chk2 11200 O96017 CHEK2 human S140 6339800 TDKYRTYsKKHFRIF FHA X -CHEK2 Chk2 O96017 human Chk2 11200 O96017 CHEK2 human S516 448840 PQVLAQPstSRkRPR X X 2669 -CHEK2 Chk2 O96017 human PSME3 10197 P61289 PSME3 human S247 15413789 EKIKRPRssNAETLy PA28_beta X X -CHEK2 Chk2 O96017 human CDC25A 993 P30304 CDC25A human S178 449126 LFTQRQNsAPARMLs M-inducer_phosp X -CHEK2 Chk2 O96017 human p53 7157 P04637 TP53 human S20 447529 PLsQEtFsDLWkLLP P53_TAD X X 9287 -CHEK2 Chk2 O96017 human CDK11B 984 P21127 CDK11B human S752 468448 QRVKRGtsPRPPEGG X X -CHEK2 Chk2 O96017 human LATS2 26524 Q9NRM7 LATS2 human S172 4744563 TPVtRRPsFEGTGDS X -CHEK2 Chk2 O96017 human RBM28 55131 Q9NW13 RBM28 human S122 3245387 RLIIRNLsFKCSEDD RRM_1 X -CHEK2 Chk2 O96017 human Chk2 11200 O96017 CHEK2 human S35 447550 sQGSSsQsQGIssss X 2665 -CHEK2 Chk2 O96017 human BLM 641 P54132 BLM human T182 41290000 sHFVRVStAQKSKKG BLM_N X X -CHEK2 Chk2 O96017 human H1C 3006 P16403 H1-2 human S36 450120 GGtPRkAsGPPVsEL X -CHEK2 Chk2 O96017 human p53 7157 P04637 TP53 human S378 447534 skkGQstsRHkkLMF X -CHEK2 Chk2 O96017 human Chk2 11200 O96017 CHEK2 human T68 447491 SsLEtVstQELYsIP X X 2197; 2661; 28130; 12812; 82263; 64180; 59068 -CHEK2 Chk2 O96017 human TIF1B 10155 Q13263 TRIM28 human S473 452391 sGVkRsRsGEGEVsG X -CHEK2 Chk2 O96017 human PKM 5315 P14618 PKM human S100 4708572 tAtEsFAsDPILyRP PK X X -CHEK2 Chk2 O96017 human HuR 1994 Q15717 ELAVL1 human S100 474553 VSYARPSsEVIkDAN X X -CHEK2 Chk2 O96017 human MDM4 4194 O15151 MDM4 human S342 470031 SkLTHSLsTSDITAI X X -CHEK2 Chk2 O96017 human Chk2 11200 O96017 CHEK2 human T387 447552 LMRtLCGtPtyLAPE Pkinase X X -CHEK2 Chk2 O96017 human Chk2 11200 O96017 CHEK2 human S379 981401 skILGEtsLMRtLCG Pkinase X X -CHEK2 Chk2 O96017 human ULK1 8408 O75385 ULK1 human S556 3176155 GLGCRLHsAPNLsDL X X 5869 -CHEK2 Chk2 O96017 human Chk2 11200 O96017 CHEK2 human T432 447553 PPFSEHRtQVsLkDQ Pkinase X -CHEK2 Chk2 O96017 human H1C 3006 P16403 H1-2 human S89 487417 LGLksLVskGtLVQT Linker_histone X -CHEK2 Chk2 O96017 human p53 7157 P04637 TP53 human S15 447490 PsVEPPLsQEtFsDL P53_TAD X 4030; 9235; 9284; 9286; 8695; 8514; 82530; 56979 -CHEK2 Chk2 O96017 human BDNF 627 P23560 BDNF human T62 30259809 GLTSLADtFEHVIEE X -CHEK2 Chk2 O96017 human Chk2 11200 O96017 CHEK2 human S120 1065318 YWFGRDksCEYCFDE FHA X -CHEK2 Chk2 O96017 human AATF 26574 Q9NY61 AATF human S477 3753303 ELIERkTsSLDPNDQ TRAUB X -CHEK2 Chk2 O96017 human SIAH2 6478 O43255 SIAH2 human S28 471339 PQPQHtPsPAAPPAA X X -CHEK2 Chk2 O96017 human Chk2 11200 O96017 CHEK2 human T225 2811405 DEYIMSktLGSGACG Pkinase X -CHEK2 Chk2 O96017 human CDC25A 993 P30304 CDC25A human S293 449128 GSTKrRKsMsGASPk M-inducer_phosp X -CHEK2 Chk2 O96017 human HuR 1994 Q15717 ELAVL1 human S88 474552 LNGLRLQskTIkVSY RRM_1 X X -CHEK2 Chk2 O96017 human MBP 618684 P02687 MBP cow T18 487421 KYLASAstMDHARHG Myelin_MBP X -CHEK2 Chk2 O96017 human MBP 618684 P02687 MBP cow T148 487419 KGHDAQGtLsKIFKL Myelin_MBP X -CHEK2 Chk2 O96017 human Chk2 11200 O96017 CHEK2 human T383 447545 GEtsLMRtLCGtPty Pkinase X X -ROR1 ROR1 Q01973 human HER3 2065 P21860 ERBB3 human Y1307 454901 HQAPHVHyARLKtLR X X -CAMK2D CAMK2D Q13557 human PKM 18746 P52480 Pkm mouse T454 23132420 RAPIIAVtRNPQTAR PK_C X X -CAMK2D CAMK2D Q13557 human HDAC4 9759 P56524 HDAC4 human S210 2631600 YGKTQHSsLDQSsPP X X -CAMK2D CAMK2D Q13557 human BMAL1 11865 Q9WTL8 Bmal1 mouse S519 1878257202 IHRIRGSsPssCGSS X -CAMK2D CAMK2D Q13557 human SCN5A 6331 Q14524 SCN5A human T594 25244201 LHGkKNStVDCNGVV Na_trans_cytopl X -CAMK2D CAMK2D Q13557 human Kv7.1 3784 P51787 KCNQ1 human T482 783280700 sMPHFMRtNsFAEDL X X -CAMK2D CAMK2D Q13557 human Kir6.2 3767 Q14654 KCNJ11 human T224 453090 MQVVRKTtSPEGEVV IRK_C X X -CAMK2D CAMK2D Q13557 human IP3R2 P29995 Itpr2 rat S150 26415703 EKNAMRVsLDAAGNE Ins145_P3_rec X -CAMK2D CAMK2D Q13557 human BMAL1 11865 Q9WTL8 Bmal1 mouse S522 1878257206 IRGSsPssCGSSPLN X -CAMK2D CAMK2D Q13557 human ANKRD28 23243 O15084 ANKRD28 human S1011 459225 TNTskTVsFEALPIM X -CAMK2D CAMK2D Q13557 human PLB 18821 P61014 Pln mouse T17 448115 SAIRRAstIEMPQQA Phospholamban X 8496 -CAMK2D CAMK2D Q13557 human RNF8 9025 O76064 RNF8 human S157 3177751 LRTKRkFsLDELAGP X -CAMK2D CAMK2D Q13557 human Titin 7273 Q8WZ42 TTN human T11922 27463601 EVEVPTVtKRERKIP X -CAMK2D CAMK2D Q13557 human CACNB2 iso2 783 Q08289-2 CACNB2 human T499 470081 RGLSRQEtFDSETQE X -CAMK2D CAMK2D Q13557 human Kv7.1 3784 P51787 KCNQ1 human S484 40556220 PHFMRtNsFAEDLDL KCNQ_channel X X -CAMK2D CAMK2D Q13557 human BMAL1 11865 Q9WTL8 Bmal1 mouse S521 1878257204 RIRGSsPssCGSSPL X -CAMK2D CAMK2D Q13557 human CEACAM1 iso8 634 P13688-8 CEACAM1 human S459 3439800 LHFGKtGsSGPLQ__ X -CAMK2D CAMK2D Q13557 human Titin 7273 Q8WZ42 TTN human S12022 4693667 RRKLRPGsGGEKPPD X -CAMK2D CAMK2D Q13557 human SCN5A 6331 Q14524 SCN5A human S516 4719558 LsLTrGLsRTsMKPR Na_trans_cytopl X -CAMK2D CAMK2D Q13557 human Titin 7273 Q8WZ42 TTN human T11932 27429703 ERKIPEPtKVPEIKP X -CAMK2D CAMK2D Q13557 human Titin 7273 Q8WZ42 TTN human T11969 27429704 PPVEPEPtPIAAPVT X -CAMK2D CAMK2D Q13557 human CAMK2D 817 Q13557 CAMK2D human T287 450982 sMMHRQEtVDCLKKF X 12716 -CAMK2D CAMK2D Q13557 human PPP3CA 24674 P63329 Ppp3ca rat S411 2048309 GKMARVFsVLREESE X -CAMK2D CAMK2D Q13557 human RYR2 20191 E9Q401 Ryr2 mouse S2813 458801 IsQtsQVsIDAAHGY X X -CAMK2D CAMK2D Q13557 human occludin 100506658 Q16625 OCLN human S471 6094301 LDDyREEsEEyMAAA Occludin_ELL X -CAMK2D CAMK2D Q13557 human CAMK2B 816 Q13554 CAMK2B human T287 450048 sMMHRQEtVECLKKF X 12716 -CAMK2D CAMK2D Q13557 human CEACAM1 iso8 634 P13688-8 CEACAM1 human T457 3439801 CFLHFGKtGsSGPLQ X X -CAMK2D CAMK2D Q13557 human Titin 7273 Q8WZ42 TTN human S11878 10029600 KEEVVLKsVLRKRPE X -GRK6 GRK6 P43250 human CXCR4 7852 P61073 CXCR4 human S324 6140803 LtsVsRGssLkILsk X 85578 -GRK6 GRK6 P43250 human GRK6 2870 P43250 GRK6 human S484 467963 VLDIEQFstVkGVEL X -GRK6 GRK6 P43250 human ADRB2 11555 P18762 Adrb2 mouse S355 458916 KTYGNGYssNSNGRT X -GRK6 GRK6 P43250 human GRK6 2870 P43250 GRK6 human T485 467964 LDIEQFstVkGVELE X -GRK6 GRK6 P43250 human ADRB2 11555 P18762 Adrb2 mouse S356 458917 TYGNGYssNSNGRTD X -GRK6 GRK6 P43250 human IGF1R 3480 P08069 IGF1R human S1321 25240303 LPLPDRHsGHKAENG X -GRK6 GRK6 P43250 human ADRB2 154 P07550 ADRB2 human S355 458916 KAyGNGyssNGNtGE X X -GRK6 GRK6 P43250 human CXCR4 7852 P61073 CXCR4 human S325 3849622 tsVsRGssLkILskG X 85578 -GRK6 GRK6 P43250 human LTB4R 1241 Q15722 LTB4R human T308 455505 VAKLLEGtGsEAsst X -GRK6 GRK6 P43250 human ADRB2 154 P07550 ADRB2 human S356 458917 AyGNGyssNGNtGEQ X X -GRK6 GRK6 P43250 human NHERF 9368 O14745 NHERF1 human S290 450313 PALVRsAssDtsEEL EBP50_C X -GRK6 GRK6 P43250 human occludin 100506658 Q16625 OCLN human S471 6094301 LDDyREEsEEyMAAA Occludin_ELL X -GRK6 GRK6 P43250 human NHERF 100009196 Q28619 SLC9A3R1 rabbit S289 450313 PALARsAssDTSEEL EBP50_C X X -Ntrk1 TrkA Q3UFB7 mouse APP 11820 P12023 App mouse Y757 448202 SkMQQNGyENPTykF APP_amyloid X -PRKCA PKCA P04409 cow TNNI3 511094 P08057 TNNI3 cow S44 450690 AKKKSKIsAsRKLQL X -PRKCA PKCA P04409 cow Rhodopsin 509933 P02699 RHO cow T336 3091410 GDDEAsttVsKtEts X -PRKCA PKCA P04409 cow TNNT2 286816 P13789 TNNT2 cow S195 451755 KAQtERKsGKRQtER Troponin X -PRKCA PKCA P04409 cow ANXA2 302 P07355 ANXA2 human S26 450879 tPPsAyGsVkAytNF X -PRKCA PKCA P04409 cow TNNI3 511094 P08057 TNNI3 cow S25 448424 PPVRRRssANYRAYA Troponin-I_N X -PRKCA PKCA P04409 cow ANXA1 327662 P46193 ANXA1 cow T24 452052 EEQEYIKtVKGsKGG X -PRKCA PKCA P04409 cow CD3G 917 P09693 CD3G human S145 12522600 GQDGVRQsRAsDkQT X -PRKCA PKCA P04409 cow RGS9 281453 O46469 RGS9 cow S475 449027 MSKLDRRsQLRKEPP X -PRKCA PKCA P04409 cow ADD2 119 P35612 ADD2 human S726 449803 KKKEKVEs_______ X -PRKCA PKCA P04409 cow IREB1 50655 Q63270 Aco1 rat S138 451387 HFNRRADsLQkNQDL Aconitase X -PRKCA PKCA P04409 cow AMPKA1 5562 Q13131 PRKAA1 human S496 450431 AtPQRsGsVsNyRSC AdenylateSensor X 4185; 4184; 2537 -PRKCA PKCA P04409 cow MRLC2 67938 Q3THE2 Myl12b mouse S2 448593 ______MssKKAKTK X -PRKCA PKCA P04409 cow H2B 615043 P62808 H2BC19 cow S32 447801 DGKKRKRsRKEsYSV Histone X -PRKCA PKCA P04409 cow Rhodopsin 509933 P02699 RHO cow S334 448677 PLGDDEAsttVsKtE X -PRKCA PKCA P04409 cow STXBP1 25558 P61765 Stxbp1 rat S306 448743 VSQEVTRsLkDFSSs Sec1 X -PRKCA PKCA P04409 cow ADD1 24170 Q63028 Add1 rat S724 449829 KKKFRTPsFLKKSKK X -PRKCA PKCA P04409 cow FGF2 2247 P09038 FGF2 human S206 451678 AEERGVVsIKGVCAN FGF X -PRKCA PKCA P04409 cow EIF4E 13684 P63073 Eif4e mouse S209 447776 DTATKSGsttKNRFV X 9741 -PRKCA PKCA P04409 cow eNOS 287024 P29473 NOS3 cow T497 447885 AGITRKktFKEVANA X -PRKCA PKCA P04409 cow TNNI3 511094 P08057 TNNI3 cow S46 450691 KKSKIsAsRKLQLKT X -PRKCA PKCA P04409 cow IREB1 100009154 Q01059 ACO1 rabbit S711 455225 REFNSYGsRRGNDAI Aconitase_C X -PRKCA PKCA P04409 cow PIK3R1 282307 P23727 PIK3R1 cow T86 22881800 RKKIsPPtPKPRPPR X -PRKCA PKCA P04409 cow Lamin B2 P14732 LMNB2 chicken S410 20657002 SsTSLVRssRGKRRR X -PRKCA PKCA P04409 cow TNNT2 286816 P13789 TNNT2 cow T200 451556 RKsGKRQtEREKKKK Troponin X -PRKCA PKCA P04409 cow ANXA2 282689 P04272 ANXA2 cow S26 450879 TPPSAyGsVKAYTNF X -PRKCA PKCA P04409 cow GJB1 29584 P08033 Gjb1 rat S233 451163 NPPSRKGsGFGHRLs X X -PRKCA PKCA P04409 cow MRLC1 10398 P24844 MYL9 human S3 4964100 _____MssKRAKAKt X -PRKCA PKCA P04409 cow MARCKS 4082 P29966 MARCKS human S159 447786 kkKKKRFsFkKsFkL MARCKS X 2741; 11992 -PRKCA PKCA P04409 cow Rhodopsin 509933 P02699 RHO cow S343 448680 tVsKtEtsQVAPA__ X -PRKCA PKCA P04409 cow MRLC1 10398 P24844 MYL9 human T10 4964102 sKRAKAKttKKRPQR X -PRKCA PKCA P04409 cow GAP43 281777 P06836 GAP43 cow S41 448719 AATKIQAsFRGHITR IQ X -PRKCA PKCA P04409 cow PDE6G 281977 P04972 PDE6G cow T35 450149 PKFKQRQtRQFKSKP PDE6_gamma X -PRKCA PKCA P04409 cow TNNI3 511094 P08057 TNNI3 cow S24 448423 PPPVRRRssANYRAY Troponin-I_N X -PRKCA PKCA P04409 cow Lamin B2 P14732 LMNB2 chicken S411 20657001 sTSLVRssRGKRRRI X -PRKCA PKCA P04409 cow ASS1 280726 P14568 ASS1 cow S328 25589104 VYTGFWHsPECEFVR Arginosuc_synth X -PRKCA PKCA P04409 cow ADD2 24171 Q05764 Add2 rat S712 449802 KKKFRTPsFLKKSKK X -PRKCA PKCA P04409 cow ANXA1 327662 P46193 ANXA1 cow S28 452053 YIKtVKGsKGGPGSA X -PRKCA PKCA P04409 cow INSR 3643 P06213 INSR human T1375 450327 KKNGRILtLPRSNPS X -PRKCA PKCA P04409 cow IREB1 48 P21399 ACO1 human S711 455225 REFNSYGsRrGNDAV Aconitase_C X -PRKCA PKCA P04409 cow H1C 513971 P02253 H1-2 cow S36 450120 AGARRKAsGPPVSEL X -PRKCA PKCA P04409 cow GJA1 24392 P08050 Gja1 rat S368 447813 QRPssRAssRAssRP X 3511; 52559 -PRKCA PKCA P04409 cow TNNI3 511094 P08057 TNNI3 cow T145 451483 RGKFKRPtLRRVRIS Troponin X -PRKCA PKCA P04409 cow ADRA1B 101843941 P18841 ADRA1B hamster S400 451003 GsLERSQsRKDsLDD X -PRKCA PKCA P04409 cow ADRA1B 101843941 P18841 ADRA1B hamster S394 451002 RPWTRGGsLERSQsR X -PRKCA PKCA P04409 cow MRLC1 10398 P24844 MYL9 human S20 1863500 KRPQRAtsNVFAMFD X 3674; 3671; 3675; 95777 -PRKCA PKCA P04409 cow ADD2 119 P35612 ADD2 human S713 449802 KKKFRtPsFLKKsKK X -PRKCA PKCA P04409 cow ADD1 118 P35611 ADD1 human S726 449829 KKKFRtPsFLKKsKK X -PRKCA PKCA P04409 cow MRLC1 10398 P24844 MYL9 human S2 4964101 ______MssKRAKAK X -PRKCA PKCA P04409 cow TNNT2 286816 P13789 TNNT2 cow T281 451557 TRGKAKVtGRWK___ X -PRKCA PKCA P04409 cow STXBP1 25558 P61765 Stxbp1 rat S313 448744 sLkDFSSsKRMNTGE Sec1 X -PRKCA PKCA P04409 cow ADD2 24171 Q05764 Add2 rat S725 449803 KKKEKVEs_______ X -PRKCA PKCA P04409 cow Rhodopsin 509933 P02699 RHO cow S338 448679 DEAsttVsKtEtsQV X -PRKCA PKCA P04409 cow IREB1 48 P21399 ACO1 human S138 451387 DFNRRADsLQkNQDL Aconitase X -PRKCA PKCA P04409 cow CD3G 917 P09693 CD3G human S148 451430 GVRQsRAsDkQTLLP X -PRKCA PKCA P04409 cow H2B 615043 P62808 H2BC19 cow S36 449903 RKRsRKEsYSVYVYK Histone X -PRKCA PKCA P04409 cow Rhodopsin 509933 P02699 RHO cow T335 10433600 LGDDEAsttVsKtEt X -PRKCA PKCA P04409 cow ADD1 118 P35611 ADD1 human S716 449828 GsPGKsPsKKKKKFR X -PRKCA PKCA P04409 cow ADD1 24170 Q63028 Add1 rat S714 449828 GSPGKSPsKKKKKFR X -STK17B DRAK2 O94768 human STAT5A 20850 P42230 Stat5a mouse S779 448750 DsLDARLsPPAGLFT X -Raf1 RAF1 Q99N57 mouse MEK1 5604 Q02750 MAP2K1 human S222 448513 LIDsMANsFVGtRSY Pkinase X 2338; 9121; 3958; 9154; 16211; 86128; 16780; 75262 -Raf1 RAF1 Q99N57 mouse MEK1 5604 Q02750 MAP2K1 human S218 448514 VsGQLIDsMANsFVG Pkinase X 9121; 3958; 9154; 86128 -Raf1 RAF1 Q99N57 mouse RAF1 110157 Q99N57 Raf1 mouse S621 447746 PKINRsAsEPsLHRA X -STK25 YSK1 O00506 human PKAR1A 5573 P10644 PRKAR1A human S83 450936 DsREDEIsPPPPNPV X X -STK25 YSK1 O00506 human CCM2 83605 Q9BSQ5 CCM2 human S384 467352 GRGIITDsFGRHRRA CCM2_C X -STK25 YSK1 O00506 human PDCD10 11235 Q9BUL8 PDCD10 human T43 7452901 VNLsAAQtLRAAFIk DUF1241 X X -STK25 YSK1 O00506 human PDCD10 11235 Q9BUL8 PDCD10 human S39 7452900 ELERVNLsAAQtLRA DUF1241 X X -STK25 YSK1 O00506 human PKAR1A 5573 P10644 PRKAR1A human S77 468450 kAGtRtDsREDEIsP X X -FLT1 VEGFR1 P17948 human VEGFR1 2321 P17948 FLT1 human Y1327 448211 CCSPPPDyNSVVLyS X -FLT1 VEGFR1 P17948 human VEGFR1 2321 P17948 FLT1 human Y1213 448209 GsSDDVRyVNAFKFM X X -FLT1 VEGFR1 P17948 human GLO1 2739 Q04760 GLO1 human Y136 463450 GIAVPDVysACkRFE Glyoxalase X -FLT1 VEGFR1 P17948 human VEGFR1 2321 P17948 FLT1 human Y1169 448208 VQQDGKDyIPINAIL X X -FLT1 VEGFR1 P17948 human VEGFR1 2321 P17948 FLT1 human Y1333 448212 DyNSVVLySTPPI__ X -FLT1 VEGFR1 P17948 human VEGFR1 2321 P17948 FLT1 human Y1242 448210 ATSMFDDyQGDSSTL X -Mapkapk2 MAPKAPK2 Q80ZF4 rat skMLCK 117558 P20689 Mylk2 rat S168 2864200 PAFLHsPsCPAIISC X -Src Src iso1 P05480-1 mouse Vimentin 22352 P20152 Vim mouse Y61 448931 sssPGGAyVtRssAV Filament_head X -Src Src iso1 P05480-1 mouse TRIP6 22051 Q9Z1Y4 Trip6 mouse Y55 456050 PLPPEHCyQPPGVPE X -Src Src iso1 P05480-1 mouse NCAM-L1 50687 Q05695 L1cam rat Y1153 466002 KRSKGGKysVKDKED Bravo_FIGEY X -Src Src iso1 P05480-1 mouse FAK 14083 P34152 Ptk2 mouse Y407 447888 IIDEEDtytMPSTRD X -Src Src iso1 P05480-1 mouse PRDX1 18477 P35700 Prdx1 mouse Y194 448924 DVnkSkEyFsKQK__ 1-cysPrx_C X -Src Src iso1 P05480-1 mouse FAK 14083 P34152 Ptk2 mouse Y576 447889 RyMEDstyyKASKGK PK_Tyr_Ser-Thr X 3281 -Src Src iso1 P05480-1 mouse DAG1 13138 Q62165 Dag1 mouse Y890 449630 PyRsPPPyVPP____ DAG1 X 32248 -Src Src iso1 P05480-1 mouse CDH2 12558 P15116 Cdh2 mouse Y884 450693 SSGGDQDyDYLNDWG CADH_Y-type_LIR X -Src Src iso1 P05480-1 mouse Src iso1 20779 P05480-1 Src mouse Y424 448234 RLIEDNEytARQGAK PK_Tyr_Ser-Thr X 2101; 6943; 59548; 70926; 78740; 94361; 17320 -Src Src iso1 P05480-1 mouse ephexin-1 53972 Q8CHT1 Ngef mouse Y177 455579 IEQIGLLyQEyRDKS X -Src Src iso1 P05480-1 mouse CTNNB1 12387 Q02248 Ctnnb1 mouse Y86 447584 VADIDGQyAMTRAQR X -Src Src iso1 P05480-1 mouse Akt1 11651 P31750 Akt1 mouse Y315 448519 tFCGtPEyLAPEVLE Pkinase X X -Src Src iso1 P05480-1 mouse NMDAR2B 14812 Q01097 Grin2b mouse Y1472 448167 GSSNGHVyEKLSSIE NMDAR2_C X 4208 -Src Src iso1 P05480-1 mouse KHDRBS3 13992 Q9R226 Khdrbs3 mouse S15 13196100 ELMAEKDsLDPSFTH Qua1 X -Src Src iso1 P05480-1 mouse ZDHHC3 69035 Q8R173 Zdhhc3 mouse Y297 56580000 GKADPyQyVV_____ X -Src Src iso1 P05480-1 mouse GIRK1 16519 P63250 Kcnj3 mouse Y12 457610 RRKFGDDyQVVTTSS X -Src Src iso1 P05480-1 mouse MTSS1 211401 Q8R1S4 Mtss1 mouse Y397 463827 HLPDYAHyyTIGPGM X X -Src Src iso1 P05480-1 mouse Cortactin 13043 Q60598 Cttn mouse Y421 447702 RPPssPIyEDAAPFK X X 4569 -Src Src iso1 P05480-1 mouse EZH2 14056 Q61188 Ezh2 mouse Y696 463307 HSVNPNCyAKVMMVN SET X -Src Src iso1 P05480-1 mouse CTNND1 12388 P30999 Ctnnd1 mouse Y228 449648 yPGGsDNyGsLsRVT X X 2911 -Src Src iso1 P05480-1 mouse LPIN1 23175 Q14693 LPIN1 human Y795 1871177712 FPNTEPFyAAFGNRP LNS2 X -Src Src iso1 P05480-1 mouse DDEF1 13196 Q9QWY8 Asap1 mouse Y308 450437 PKEVGGLyVASRANS X -Src Src iso1 P05480-1 mouse PKCD 18753 P28867 Prkcd mouse Y187 447579 WGLNkQGyKCRQCNA C1_1 X -Src Src iso1 P05480-1 mouse nectin 2 19294 P32507 Nectin2 mouse Y505 3971844 LDKINPIyDALSYPS X -Src Src iso1 P05480-1 mouse MOR-1 18390 P42866 Oprm1 mouse Y336 5397200 SCLNPVLyAFLDENF 7tm_1 X -Src Src iso1 P05480-1 mouse IGF1R 16001 Q60751 Igf1r mouse Y974 449827 RLGNGVLyASVNPEy X X -Src Src iso1 P05480-1 mouse LPIN1 23175 Q14693 LPIN1 human Y413 1871177711 DPEVAALyFPKNGDP X -Src Src iso1 P05480-1 mouse ARHGEF7 54126 Q9ES28 Arhgef7 mouse Y755 1443172900 DLsEDSEyDSIWTAH X -Src Src iso1 P05480-1 mouse EGFR 1956 P00533 EGFR human Y1092 448057 tFLPVPEyINQsVPk X 2236; 2234; 3777; 14565; 8543; 48576 -Src Src iso1 P05480-1 mouse CTNNB1 12387 Q02248 Ctnnb1 mouse Y654 447585 RNEGVATyAAAVLFR X -Src Src iso1 P05480-1 mouse CTNND1 12388 P30999 Ctnnd1 mouse Y302 450177 DyGMMsDyGtARRtG X X -Src Src iso1 P05480-1 mouse IGF1R 16001 Q60751 Igf1r mouse Y981 448390 yASVNPEyFSAADVY X X 4568 -Src Src iso1 P05480-1 mouse TGFBR2 7048 P37173 TGFBR2 human Y284 479864 KIFPYEEyASWKTEk PK_Tyr_Ser-Thr X -Src Src iso1 P05480-1 mouse PKCD 18753 P28867 Prkcd mouse Y332 450077 ILDNNGTyGKIWEGS X X -Src Src iso1 P05480-1 mouse CTNND1 12388 P30999 Ctnnd1 mouse Y296 450176 MGyDDLDyGMMsDyG X X -Src Src iso1 P05480-1 mouse IGF1R 16001 Q60751 Igf1r mouse Y1167 448387 RDIyEtDyyRKGGkG PK_Tyr_Ser-Thr X 3024; 3918; 2969 -Src Src iso1 P05480-1 mouse Cortactin 13043 Q60598 Cttn mouse Y482 447704 yQAEDDTyDGYESDL X -Src Src iso1 P05480-1 mouse DNAJB4 67035 Q9D832 Dnajb4 mouse Y172 450786 KVSLEEIySGCTKRM DnaJ_C X -Src Src iso1 P05480-1 mouse TLR3 364594 Q7TNI8 Tlr3 rat Y760 450187 EQFEYTAyIIHAQKD TIR X -Src Src iso1 P05480-1 mouse Pyk2 19229 Q9QVP9 Ptk2b mouse Y881 447958 DRTDDLVyHNVMTLV Focal_AT X -Src Src iso1 P05480-1 mouse ACP1 280977 Q3SZ94 ACP1 cow Y132 450718 QLIIEDPyyGNDADF LMWPc X -Src Src iso1 P05480-1 mouse Cortactin 13043 Q60598 Cttn mouse Y475 3973973 TTEAPGHyQAEDDTy X -Src Src iso1 P05480-1 mouse APP iso2 11820 P12023-2 App mouse Y682 448202 SkMQQNGyENPTykF APP_amyloid X -Src Src iso1 P05480-1 mouse TBK1 29110 Q9UHD2 TBK1 human Y179 23151249 sLyGTEEyLHPDMYE Pkinase X -Src Src iso1 P05480-1 mouse PXN 19303 Q8VI36 Pxn mouse Y118 448604 AGEEEHVysFPNKQk Paxillin X 2541; 69363 -Src Src iso1 P05480-1 mouse PLCG1 18803 Q62077 Plcg1 mouse Y783 447667 EGRNPGFyVEANPMP X 2821; 14461; 14008; 25678; 88717 -Src Src iso1 P05480-1 mouse IGF1R 16001 Q60751 Igf1r mouse Y1163 448386 FGMTRDIyEtDyyRK PK_Tyr_Ser-Thr X X 3021; 80732 -Src Src iso1 P05480-1 mouse IGF1R 16001 Q60751 Igf1r mouse Y1352 448389 sFDERQPyAHMNGGR X X 28897 -Src Src iso1 P05480-1 mouse STAT3 20848 P42227 Stat3 mouse Y705 448192 DPGsAAPyLktkFIC X 4093; 9145; 4324; 9131; 9138; 4323; 4074; 4113; 48313; 20977; 25023; 8119; 52075; 52527; 73533; 61958; 73452; 16185; 74309 -Src Src iso1 P05480-1 mouse CDH2 12558 P15116 Cdh2 mouse Y852 450692 NDPTAPPyDSLLVFD CADH_Y-type_LIR X -Src Src iso1 P05480-1 mouse CTNND1 12388 P30999 Ctnnd1 mouse Y112 472275 PGQIVETyTEEDPEG X X -Src Src iso1 P05480-1 mouse TLR3 142980 Q99MB1 Tlr3 mouse Y760 450187 EQFEYTAyIIHAHkD TIR X -Src Src iso1 P05480-1 mouse FAK 14083 P34152 Ptk2 mouse Y397 447887 sVsEtDDyAEIIDEE X 3283; 8556 -Src Src iso1 P05480-1 mouse PKHF1 72287 Q3TB82 Plekhf1 mouse Y208 1868624702 LRVCSLCyRELAAQK FYVE X -Src Src iso1 P05480-1 mouse Akt1 11651 P31750 Akt1 mouse Y326 447858 EVLEDNDyGRAVDWW Pkinase X X -Src Src iso1 P05480-1 mouse Ezrin 7430 P15311 EZR human Y478 454875 PPPPPPVyEPVsyHV X -Src Src iso1 P05480-1 mouse ZDHHC3 69035 Q8R173 Zdhhc3 mouse Y295 464577 DQGKADPyQyVV___ X -Src Src iso1 P05480-1 mouse DAB1 13131 P97318 Dab1 mouse Y220 447630 PETEENIyQVPTSQK X 3327 -Src Src iso1 P05480-1 mouse Vimentin 22352 P20152 Vim mouse Y117 450350 LNDRFANyIDkVRFL Filament X -Src Src iso1 P05480-1 mouse FAK 14083 P34152 Ptk2 mouse Y577 447890 yMEDstyyKASKGKL PK_Tyr_Ser-Thr X 3281 -Src Src iso1 P05480-1 mouse Vimentin 22352 P20152 Vim mouse Y53 448930 PstsRsLysssPGGA Filament_head X -Src Src iso1 P05480-1 mouse EGFR 13649 Q01279 Egfr mouse Y871 448061 LGAEEkEyHAEGGkV PK_Tyr_Ser-Thr X 2231; 6963 -Src Src iso1 P05480-1 mouse PKCD 18753 P28867 Prkcd mouse Y311 447573 TTEsVGIyQGFEKKP X X 2055 -Src Src iso1 P05480-1 mouse EGFR 1956 P00533 EGFR human Y869 448061 LGAEEkEyHAEGGkV PK_Tyr_Ser-Thr X 2231; 6963 -Src Src iso1 P05480-1 mouse EFNB1 13641 P52795 Efnb1 mouse Y328 448343 GDyGHPVyIVQEMPP X 3481 -Src Src iso1 P05480-1 mouse PKCD 18753 P28867 Prkcd mouse Y155 447575 IKQAKIHyIKNHEFI X -Src Src iso1 P05480-1 mouse IGF1R 16001 Q60751 Igf1r mouse Y1168 448388 DIyEtDyyRKGGkGL PK_Tyr_Ser-Thr X X 3024; 2969 -Src Src iso1 P05480-1 mouse PXN 19303 Q8VI36 Pxn mouse Y31 448785 FLsEEPPysyPTGNH X -Src Src iso1 P05480-1 mouse CTNND1 12388 P30999 Ctnnd1 mouse Y280 450398 HRFHPEPyGLEDDQR X X -Src Src iso1 P05480-1 mouse ACP1 280977 Q3SZ94 ACP1 cow Y133 457445 LIIEDPyyGNDADFE LMWPc X -Src Src iso1 P05480-1 mouse CTNND1 12388 P30999 Ctnnd1 mouse Y291 450175 DDQRsMGyDDLDyGM X X -Src Src iso1 P05480-1 mouse UGCG 22234 O88693 Ugcg mouse Y132 26420454 INNLMPAyEVAKYDL Glyco_transf_21 X -Src Src iso1 P05480-1 mouse Kit 3815 P10721 KIT human Y900 450042 EHAPAEMyDIMKTCW PK_Tyr_Ser-Thr X X -Src Src iso1 P05480-1 mouse RAF1 110157 Q99N57 Raf1 mouse Y341 447750 GQRDssyyWEIEASE X -Src Src iso1 P05480-1 mouse Moesin 4478 P26038 MSN human T558 447706 LGRDKyKtLRQIRQG ERM_C X 3141; 3726; 32600 -Src Src iso1 P05480-1 mouse emerin 13726 O08579 Emd mouse Y75 451787 AAVDSDMyDLPKkED X -Src Src iso1 P05480-1 mouse Ret 5979 P07949 RET human Y905 447627 DVyEEDsyVKRsQGR PK_Tyr_Ser-Thr X 3221 -Src Src iso1 P05480-1 mouse PKHF1 72287 Q3TB82 Plekhf1 mouse Y268 1868624701 WPTQVEFyASGVSWS X -Src Src iso1 P05480-1 mouse Cortactin 13043 Q60598 Cttn mouse Y466 447703 TyTSEPVyETTEAPG X X -Src Src iso1 P05480-1 mouse IkB-alpha 4792 P25963 NFKBIA human Y42 448737 DsMkDEEyEQMVkEL X -Src Src iso1 P05480-1 mouse emerin 13726 O08579 Emd mouse Y96 448938 kDYNDDyyEESYLTT X -Src Src iso1 P05480-1 mouse LPIN1 23175 Q14693 LPIN1 human Y398 1871177710 HLGADGVyLDDLTDM X -Src Src iso1 P05480-1 mouse P130Cas 12927 Q61140 Bcar1 mouse Y668 448399 EGGWMEDyDyVHLQG CAS_C X -Src Src iso1 P05480-1 mouse Pyk2 19229 Q9QVP9 Ptk2b mouse Y402 447955 CSIESDIyAEIPDET X 3291 -Src Src iso1 P05480-1 mouse SPRY2 24064 Q9QXV8 Spry2 mouse Y55 448849 AIRNTNEyTEGPTVV X -Src Src iso1 P05480-1 mouse ROBO3 19649 Q9Z2I4 Robo3 mouse Y1019 37043702 ASGEGPVySTIDPVG X -Src Src iso1 P05480-1 mouse caveolin-1 12389 P49817 Cav1 mouse Y14 448422 VDsEGHLytVPIREQ X 3251 -Src Src iso1 P05480-1 mouse STXBP1 20910 O08599 Stxbp1 mouse Y473 450386 ERISEQTyQLSRWtP Sec1 X -Src Src iso1 P05480-1 mouse Src 6714 P12931 SRC human Y419 448234 RLIEDNEytARQGAk PK_Tyr_Ser-Thr X 2101; 6943; 59548; 70926; 78740; 94361; 17320 -Src Src iso1 P05480-1 mouse ROCK2 19878 P70336 Rock2 mouse Y722 464192 LADKNKIyEsIEEAK X -Src Src iso1 P05480-1 mouse CTNND1 12388 P30999 Ctnnd1 mouse Y96 449495 QDHNHLLystIPRMQ X X -Src Src iso1 P05480-1 mouse PTPRA 19262 P18052 Ptpra mouse Y825 447613 YIDAFsDyANFK___ X X 4481 -Src Src iso1 P05480-1 mouse CTNND1 12388 P30999 Ctnnd1 mouse Y257 450397 APsRQDVyGPQPQVR X X -Src Src iso1 P05480-1 mouse EFNB1 13641 P52795 Efnb1 mouse Y323 448342 yEkVsGDyGHPVyIV X 3481 -Src Src iso1 P05480-1 mouse Pyk2 19229 Q9QVP9 Ptk2b mouse Y580 447957 yIEDEDyyKASVTRL PK_Tyr_Ser-Thr X -Src Src iso1 P05480-1 mouse MTSS1 211401 Q8R1S4 Mtss1 mouse Y398 473757 LPDYAHyyTIGPGMF X X -Cdk6 CDK6 F1MA87 rat PKLR iso2 24651 P12928-2 Pklr rat S113 31084572 ATESFATsPLSYRPV PK X -WNK3 WNK3 Q9BYP7 human WNK1 65125 Q9H4A3 WNK1 human S382 454105 kRAsFAKsVIGTPEF Pkinase X -WNK3 WNK3 Q9BYP7 human KCC3 9990 Q9UHW9 SLC12A6 human T991 4770536 SAYTYERtLMMEQRS SLC12 X -WNK3 WNK3 Q9BYP7 human NKCC2 25065 P55016 Slc12a1 rat T96 458227 TNTYYLQtFGHNtMD AA_permease_N X -WNK3 WNK3 Q9BYP7 human NCCT 54300 P55018 Slc12a3 rat T58 469617 LRtFGYNtIDVVPAY AA_permease_N X -WNK3 WNK3 Q9BYP7 human KCC3 9990 Q9UHW9 SLC12A6 human T1048 4770548 YQEKVHMtWTKDKYM SLC12 X -WNK3 WNK3 Q9BYP7 human KCC3 9990 Q9UHW9 SLC12A6 human S96 10787161 IEDLSQNsITGEHSQ X -WNK3 WNK3 Q9BYP7 human NKCC2 25065 P55016 Slc12a1 rat T101 458228 LQtFGHNtMDAVPKI AA_permease_N X -Tssk2 TSSK2 O54863 mouse TSKS 22116 O54887 Tsks mouse S281 2797600 GCSGPPGsPEEPPRQ TSKS X -RIPK2 RIPK2 O43353 human RIPK2 8767 O43353 RIPK2 human S181 22641182 sLsQsRsskSAPEGG PK_Tyr_Ser-Thr X -RIPK2 RIPK2 O43353 human RIPK2 8767 O43353 RIPK2 human S180 25752142 MsLsQsRsskSAPEG PK_Tyr_Ser-Thr X -RIPK2 RIPK2 O43353 human RIPK2 8767 O43353 RIPK2 human S174 7444668 LsKWRMMsLsQsRss PK_Tyr_Ser-Thr X -RIPK2 RIPK2 O43353 human RIPK2 8767 O43353 RIPK2 human S176 460844 KWRMMsLsQsRsskS PK_Tyr_Ser-Thr X X 14397 -RIPK2 RIPK2 O43353 human RIPK2 8767 O43353 RIPK2 human S178 4272808 RMMsLsQsRsskSAP PK_Tyr_Ser-Thr X -RIPK2 RIPK2 O43353 human RIPK2 8767 O43353 RIPK2 human Y474 4270705 DLIMKEDyELVSTkP CARD X X -EPHA6 EphA6 Q9UF33 human GLO1 2739 Q04760 GLO1 human Y136 463450 GIAVPDVysACkRFE Glyoxalase X -Prkaa2 AMPKA2 Q09137 rat ACC1 60581 P11497 Acaca rat S1215 449868 YGMTHVAsVSDVLLD ACC_central X -Prkaa2 AMPKA2 Q09137 rat NHE5 6553 Q14940 SLC9A5 human S851 34424903 SLAKAGRsRsEssAD X X -Prkaa2 AMPKA2 Q09137 rat PGC-1 alpha 19017 O70343 Ppargc1a mouse S538 486320 SLFDVSPsCSSFNSP X -Prkaa2 AMPKA2 Q09137 rat NHE5 6553 Q14940 SLC9A5 human S620 34424901 RRYKAsCsRHFISED X X -Prkaa2 AMPKA2 Q09137 rat ACC1 60581 P11497 Acaca rat S79 448292 FHMRSsMsGLHLVKQ X 3661; 11818; 42801 -Prkaa2 AMPKA2 Q09137 rat NHE5 6553 Q14940 SLC9A5 human S575 34424900 VTNLLREsGsGACLD X X -Prkaa2 AMPKA2 Q09137 rat NHE5 6553 Q14940 SLC9A5 human S618 34424907 PRRRYKAsCsRHFIS X X -Prkaa2 AMPKA2 Q09137 rat NHE5 6553 Q14940 SLC9A5 human S577 34424902 NLLREsGsGACLDLQ X X -Prkaa2 AMPKA2 Q09137 rat PGC-1 alpha 19017 O70343 Ppargc1a mouse T177 486319 NHTHRIRtNPAIVkT X -Prkaa2 AMPKA2 Q09137 rat NHE5 6553 Q14940 SLC9A5 human S856 34424905 GRsRsEssADLPQQQ X X -Prkaa2 AMPKA2 Q09137 rat ACC1 60581 P11497 Acaca rat S1200 448290 IPtLNRMsFASNLNH ACC_central X -Prkaa2 AMPKA2 Q09137 rat NHE5 6553 Q14940 SLC9A5 human S853 34424904 AKAGRsRsEssADLP X X -Prkaa2 AMPKA2 Q09137 rat NHE5 6553 Q14940 SLC9A5 human S855 34424906 AGRsRsEssADLPQQ X X -IGF1R IGF1R P08069 human IRS1 3667 P35568 IRS1 human Y989 451287 VPssRGDyMTMQMSC X -IGF1R IGF1R P08069 human PDK1 5170 O15530 PDPK1 human Y376 447695 DEDCyGNyDNLLSQF X X -IGF1R IGF1R P08069 human PTHR 5745 Q03431 PTH1R human Y494 28764913 ARsGsssySyGPMVS X -IGF1R IGF1R P08069 human IRS1 3667 P35568 IRS1 human Y632 447565 GRKGsGDyMPMsPKs X -IGF1R IGF1R P08069 human ANXA2 302 P07355 ANXA2 human Y24 449483 HstPPsAyGsVkAyt X -IGF1R IGF1R P08069 human PCNA 5111 P12004 PCNA human Y250 231166701 DMGHLkYyLAPkIED PCNA_C X X -IGF1R IGF1R P08069 human IRS1 3667 P35568 IRS1 human Y941 448700 EEtGtEEyMKMDLGP X -IGF1R IGF1R P08069 human IRS4 8471 O14654 IRS4 human Y921 456294 EADSSsDyVNMDFTk X -IGF1R IGF1R P08069 human IRS1 3667 P35568 IRS1 human Y662 450356 QRVDPNGyMMMsPsG X -IGF1R IGF1R P08069 human IRS1 3667 P35568 IRS1 human Y896 447556 EPKsPGEyVNIEFGS X 3070 -IGF1R IGF1R P08069 human ER-alpha 2099 P03372 ESR1 human Y219 12620700 sIQGHNDyMCPATNQ zf-C4 X X -IGF1R IGF1R P08069 human IGF1R 3480 P08069 IGF1R human Y1161 448386 FGMTRDIyEtDyyRk PK_Tyr_Ser-Thr X X 3021; 80732 -IGF1R IGF1R P08069 human IRS4 8471 O14654 IRS4 human Y828 456293 GQNDNsEyVPMLPGk X -IGF1R IGF1R P08069 human IRS1 3667 P35568 IRS1 human Y1179 451288 GLENGLNyIDLDLVk X -IGF1R IGF1R P08069 human PCNA 5111 P12004 PCNA human Y60 38486265 RSEGFDTyrCDRNLA PCNA_N X X -IGF1R IGF1R P08069 human IGF1R 3480 P08069 IGF1R human Y1281 450102 FREVsFyySEENKLP X -IGF1R IGF1R P08069 human SHPS1 140885 P78324 SIRPA human Y470 451114 AsEDtLtyADLDMVH X X -IGF1R IGF1R P08069 human PDK1 5170 O15530 PDPK1 human Y373 447694 sEDDEDCyGNyDNLL X X -IGF1R IGF1R P08069 human IGF1R 3480 P08069 IGF1R human S982 7493700 SVNPEyFsAADVYVP X -IGF1R IGF1R P08069 human IRS4 8471 O14654 IRS4 human Y847 1877150802 GLDkEVSyNWDPKDA X -IGF1R IGF1R P08069 human H3 8350 P68431 H3C1 human Y41 10897613 GVkkPHryrPGtVAL Histone X X -IGF1R IGF1R P08069 human IGF1R 3480 P08069 IGF1R human Y980 448390 yASVNPEyFsAADVY X 4568 -IGF1R IGF1R P08069 human PCNA 5111 P12004 PCNA human Y133 231166700 LGIPEQEysCVVkMP PCNA_C X X -IGF1R IGF1R P08069 human IRS4 8471 O14654 IRS4 human Y656 1877150800 SGGRFRLyFCVDrGA X -IGF1R IGF1R P08069 human IGF1R 3480 P08069 IGF1R human Y1165 448387 RDIyEtDyyRkGGkG PK_Tyr_Ser-Thr X X 3024; 3918; 2969 -IGF1R IGF1R P08069 human IRS1 3667 P35568 IRS1 human Y732 23116331 LLPCTGDyMNMSPVG X -IGF1R IGF1R P08069 human IGF1R 3480 P08069 IGF1R human Y1280 450101 GFREVsFyySEENKL X -IGF1R IGF1R P08069 human IGF1R 3480 P08069 IGF1R human Y1166 448388 DIyEtDyyRkGGkGL PK_Tyr_Ser-Thr X 3024; 3918; 2969 -IGF1R IGF1R P08069 human SHPS1 140885 P78324 SIRPA human Y496 451115 PEPSFsEyASVQVPR X X -Nme1 NME1 Q05982 rat ALDOC 24191 P09117 Aldoc rat D319 8075400 SAWRGQRdNAGAATE Glycolytic X -Tbk1 TBK1 Q9WUN2 mouse STAT3 20848 P42227 Stat3 mouse S727 448191 NtIDLPMsPRTLDSL X 9134; 9136; 34911; 94994; 49081; 58978; 87544; 71958; 50804 -Tbk1 TBK1 Q9WUN2 mouse STING 72512 Q3TBT3 Sting1 mouse S365 31064700 QEPRLLIsGMDQPLP X X 62912; 72971; 51865 -Tbk1 TBK1 Q9WUN2 mouse IRF3 54131 P70671 Irf3 mouse S388 449028 KTVDLHIsNSQPISL X 4947; 29047; 83611; 10327; 53539; 81093; 52270; 61166 -MAP3K10 MLK2 Q02779 human DYRK2 8445 Q92630 DYRK2 human T381 3303402 YEHQRVytyIQsRFY Pkinase X -MAP3K10 MLK2 Q02779 human E2A 6929 P15923 TCF3 human S379 3180968 AGAPGALsPsyDGGL X X -MAP3K10 MLK2 Q02779 human E2A 6929 P15923 TCF3 human T355 455166 NFsssPstPVGsPQG X X -MAP3K10 MLK2 Q02779 human E2A 6929 P15923 TCF3 human S359 465682 sPstPVGsPQGLAGt X X -MAP3K10 MLK2 Q02779 human E2A 6929 P15923 TCF3 human S341 10359100 KALASIYsPDHssNN X X -MAP3K10 MLK2 Q02779 human E2A 6929 P15923 TCF3 human S352 465681 ssNNFsssPstPVGs X X -MAP3K10 MLK2 Q02779 human DYRK2 8445 Q92630 DYRK2 human S449 3303401 sQKLLDAsKRAKNFV Pkinase X -DMPK DMPK1 Q09013 human SRF 6722 P11831 SRF human T159 449631 DNkLRRYtTFsKRkT SRF-TF X X -TGFBR2 TGFBR2 P37173 human TGFBR1 7046 P36897 TGFBR1 human T185 448248 kDLIyDMttsGsGsG TGF_beta_GS X -TGFBR2 TGFBR2 P37173 human USP2 9099 O75604 USP2 human S207 803501400 ENYGRKGsASQVPSQ X -TGFBR2 TGFBR2 P37173 human TGFBR2 7048 P37173 TGFBR2 human S213 452047 TRkLMEFsEHCAIIL X -TGFBR2 TGFBR2 P37173 human USP2 9099 O75604 USP2 human S225 803501401 SRVPEIIsPTYRPIG X -TGFBR2 TGFBR2 P37173 human TGFBR1 7046 P36897 TGFBR1 human S187 448245 LIyDMttsGsGsGLP TGF_beta_GS X -TGFBR2 TGFBR2 P37173 human ENG 2022 P17813 ENG human S634 465618 VAVAAPAssESSStN X -TGFBR2 TGFBR2 P37173 human TGFBR2 7048 P37173 TGFBR2 human Y259 2869604 KGRFAEVykAKLkQN PK_Tyr_Ser-Thr X -TGFBR2 TGFBR2 P37173 human TGFBR1 7046 P36897 TGFBR1 human S191 448247 MttsGsGsGLPLLVQ TGF_beta_GS X -TGFBR2 TGFBR2 P37173 human TGFBR2 7048 P37173 TGFBR2 human S416 452049 sVDDLANsGQVGTAR PK_Tyr_Ser-Thr X -TGFBR2 TGFBR2 P37173 human TGFBR2 7048 P37173 TGFBR2 human Y424 2869602 GQVGTARyMAPEVLE PK_Tyr_Ser-Thr X -TGFBR2 TGFBR2 P37173 human TGFBR2 7048 P37173 TGFBR2 human S409 452048 LRLDPTLsVDDLANs PK_Tyr_Ser-Thr X -TGFBR2 TGFBR2 P37173 human TGFBR1 7046 P36897 TGFBR1 human S189 448246 yDMttsGsGsGLPLL TGF_beta_GS X -TGFBR2 TGFBR2 P37173 human ENG 2022 P17813 ENG human S635 465619 AVAAPAssESSStNH X -TGFBR2 TGFBR2 P37173 human TGFBR2 7048 P37173 TGFBR2 human Y336 2869603 AKGNLQEyLTRHVIS PK_Tyr_Ser-Thr X -TGFBR2 TGFBR2 P37173 human TGFBR1 7046 P36897 TGFBR1 human T200 4325704 LPLLVQRtIARtIVL TGF_beta_GS X -TGFBR2 TGFBR2 P37173 human TGFBR1 7046 P36897 TGFBR1 human T186 448249 DLIyDMttsGsGsGL TGF_beta_GS X -Hipk2 HIPK2 Q9QZR5 mouse MECP2 4204 P51608 MECP2 human S80 452713 AVPEAsAsPKQRRsI X X -Hipk2 HIPK2 Q9QZR5 mouse HIPK2 15258 Q9QZR5 Hipk2 mouse Y361 449571 SKAVCStyLQsRYYR Pkinase X -Hipk2 HIPK2 Q9QZR5 mouse MECP2 17257 Q9Z2D6 Mecp2 mouse S80 452713 AVPEAsAsPKQRRsI X -LRRK1 LRRK1 Q38SD2 human NDEL1 81565 Q9GZM8 NDEL1 human S155 25746642 ERNAFLEsELDEKEs NUDE_C X X -LRRK1 LRRK1 Q38SD2 human Restin iso3 6249 P30622-2 CLIP1 human T36 36744506 VVAPVEKtISSEKAS X X -LRRK1 LRRK1 Q38SD2 human Restin iso3 6249 P30622-2 CLIP1 human S1225 36744507 ASAKSLHsVVQTLES X X -LRRK1 LRRK1 Q38SD2 human Restin iso3 6249 P30622-2 CLIP1 human T191 3189760 PISNLTKtASEsISN X X -LRRK1 LRRK1 Q38SD2 human Rab7 7879 P51149 RAB7A human S72 468547 AGQERFQsLGVAFYR Ras X X -LRRK1 LRRK1 Q38SD2 human Restin iso3 6249 P30622-2 CLIP1 human T13 36744504 PSGLKAPtKILKPGS X X -LRRK1 LRRK1 Q38SD2 human NDEL1 81565 Q9GZM8 NDEL1 human S166 27722642 EKEsLLVsVQRLKDE NUDE_C X -LRRK1 LRRK1 Q38SD2 human Restin iso3 6249 P30622-2 CLIP1 human S1318 3189736 DDLNNYDsDDQEKQS X X -LRRK1 LRRK1 Q38SD2 human Restin iso3 6249 P30622-2 CLIP1 human T1384 36744502 EMFGHWAtNCNDDET CLIP1_ZNF X X -LRRK1 LRRK1 Q38SD2 human Restin iso3 6249 P30622-2 CLIP1 human T1099 36744508 NKSKELLtVENQKME X X -LRRK1 LRRK1 Q38SD2 human NDEL1 81565 Q9GZM8 NDEL1 human S213 40722081 MDsAVQAsLsLPAtP NUDE_C X -LRRK1 LRRK1 Q38SD2 human Restin iso3 6249 P30622-2 CLIP1 human T459 36744505 KGDLEVAtVSEkSRI X X -LRRK1 LRRK1 Q38SD2 human NDEL1 81565 Q9GZM8 NDEL1 human S162 25746646 sELDEKEsLLVsVQR NUDE_C X -LRRK1 LRRK1 Q38SD2 human NDEL1 81565 Q9GZM8 NDEL1 human T132 478045 LERAKRAtIVsLEDF X -LRRK1 LRRK1 Q38SD2 human Rab7 19349 P51150 Rab7a mouse S72 468547 AGQERFQsLGVAFYR Ras X -LRRK1 LRRK1 Q38SD2 human Restin iso3 6249 P30622-2 CLIP1 human S1190 3639977 ASLQKsIsITSALLT X X -LRRK1 LRRK1 Q38SD2 human CDK5RAP2 55755 Q96SN8 CDK5RAP2 human T102 41694203 PTEHIYKtNIELKVE Cnn_1N X -LRRK1 LRRK1 Q38SD2 human CDK5RAP2 55755 Q96SN8 CDK5RAP2 human S140 41694200 SLAEAGGsEIQRVKE X -LRRK1 LRRK1 Q38SD2 human Restin iso3 6249 P30622-2 CLIP1 human S1188 5678035 EKASLQKsIsITSAL X X -LRRK1 LRRK1 Q38SD2 human Restin iso3 6249 P30622-2 CLIP1 human T27 36744509 STALKTPtAVVAPVE X X -LRRK1 LRRK1 Q38SD2 human NDEL1 81565 Q9GZM8 NDEL1 human S95 1880106500 AQSYKQVsVLEDDLS X -Mink1 MINK Q9JM52 mouse NLRP3 216799 Q8R4B8 Nlrp3 mouse S725 31904665 VNCCLTSsFCRGLFS X -CLK1 CLK1 P49759 human Abl 25 P00519 ABL1 human T735 450291 DTEWRSVtLPRDLQS X 2864 -CLK1 CLK1 P49759 human RBM17 84991 Q96I25 RBM17 human S222 3209223 EEQDRPRsPtGPsNs X X -CLK1 CLK1 P49759 human RBM17 84991 Q96I25 RBM17 human S288 27936103 DATEkDAsKKsDsNP X X -CLK1 CLK1 P49759 human PTP1B 5770 P18031 PTPN1 human S243 9921201 DKRkDPssVDIkKVL Y_phosphatase X -CLK1 CLK1 P49759 human snRNP 70 6625 P08621 SNRNP70 human S226 451900 yDERPGPsPLPHRDR X X -CLK1 CLK1 P49759 human RBM20 309544 E9PT37 Rbm20 rat S638 31086436 YGPERPRsRsPMsRs X X -CLK1 CLK1 P49759 human RBM17 84991 Q96I25 RBM17 human S204 476471 DsRPRsQsSKAAIPP X X -CLK1 CLK1 P49759 human RBM17 84991 Q96I25 RBM17 human S62 27936100 IDLkRGGsSDDrQIV X X -CLK1 CLK1 P49759 human PTP1B 5770 P18031 PTPN1 human S50 447811 RNRyRDVsPFDHsRI Y_phosphatase X -CLK1 CLK1 P49759 human RBM17 84991 Q96I25 RBM17 human S202 27936104 EEDsRPRsQsSKAAI X X -CLK1 CLK1 P49759 human RBM17 84991 Q96I25 RBM17 human S266 27459081 QGLSTALsVEKTSKr G-patch X X -CLK1 CLK1 P49759 human RBM17 84991 Q96I25 RBM17 human S291 27936102 EkDAsKKsDsNPLTE X X -CLK1 CLK1 P49759 human RBM17 84991 Q96I25 RBM17 human S48 27936101 kSQRTkQsTVLAPVI X X -CLK1 CLK1 P49759 human RBM20 309544 E9PT37 Rbm20 rat S640 31086439 PERPRsRsPMsRsLS X X -CLK1 CLK1 P49759 human PTP1B 5770 P18031 PTPN1 human S242 9921200 MDKRkDPssVDIkKV Y_phosphatase X -CLK1 CLK1 P49759 human Trap150 230753 Q569Z6 Thrap3 mouse S243 452511 RAsVsDLsPRERsPA THRAP3_BCLAF1 X -CLK1 CLK1 P49759 human STF-1 2516 Q13285 NR5A1 human S203 447603 EYPEPYAsPPQPGLP X -Pkn1 PKN1 Q63433 rat PKN1 29355 Q63433 Pkn1 rat S577 458294 PAGLPSTsCsLSSPT X -Pkn1 PKN1 Q63433 rat PKN1 29355 Q63433 Pkn1 rat T504 458293 FSKQQGQtFQRARQM X -Pkn1 PKN1 Q63433 rat PKN1 29355 Q63433 Pkn1 rat T64 452112 ENLRRATtDLGRSLA HR1 X -Pkn1 PKN1 Q63433 rat PKN1 29355 Q63433 Pkn1 rat S377 452113 GLYNRSGsLSGRSSL X -Pkn1 PKN1 Q63433 rat PKN1 29355 Q63433 Pkn1 rat S579 458295 GLPSTsCsLSSPTHE X -Pkn1 PKN1 Q63433 rat PKN1 29355 Q63433 Pkn1 rat S534 452114 PNAVATGsFSPNASP X -Pkn1 PKN1 Q63433 rat PKN1 29355 Q63433 Pkn1 rat T778 447835 GYGDRtStFCGTPEF Pkinase X 2611 -Pkn1 PKN1 Q63433 rat PPP1R14A 114004 Q99MC0 Ppp1r14a rat T38 449098 QKRHARVtVkYDRRE PP1_inhibitor X -Pkn1 PKN1 Q63433 rat PKN1 29355 Q63433 Pkn1 rat S612 458296 LCSPLRKsPLTLEDF X -BRSK2 BRSK2 Q8IWQ3 human Tau iso8 4137 P10636-8 MAPT human S262 447930 NVKskIGstENLkHQ Tubulin-binding X -BRSK2 BRSK2 Q8IWQ3 human AMPKA1 5562 Q13131 PRKAA1 human T183 448786 sDGEFLRtsCGsPNy Pkinase X 2535; 2531; 4188; 5256; 50081; 74281 -BRSK2 BRSK2 Q8IWQ3 human RhoGDI alpha 396 P52565 ARHGDIA human S174 452196 kGMLARGsYsIkSRF Rho_GDI X X -BRSK2 BRSK2 Q8IWQ3 human TSC2 7249 P49815 TSC2 human S1387 450212 QPLsKssssPELQtL X 5584; 23402 -BRSK2 BRSK2 Q8IWQ3 human Tau iso8 4137 P10636-8 MAPT human S356 449104 rVQskIGsLDNItHV Tubulin-binding X -BRSK2 BRSK2 Q8IWQ3 human CDK16 5127 Q00536 CDK16 human S12 453448 KKIKRQLsMtLRGGr X X -Fer Fer P70451 mouse PECAM-1 18613 Q08481 Pecam1 mouse Y702 448760 TRATETVysEIRKVD X -Fer Fer P70451 mouse STAT3 6774 P40763 STAT3 human Y705 448192 DPGsAAPyLktKFIC X X 4093; 9145; 4324; 9131; 9138; 4323; 4074; 4113; 48313; 20977; 25023; 8119; 52075; 52527; 73533; 61958; 73452; 16185; 74309 -Fer Fer P70451 mouse PECAM-1 18613 Q08481 Pecam1 mouse Y717 465455 PNLMENRysRTEGSL X -Fer Fer P70451 mouse PECAM-1 18613 Q08481 Pecam1 mouse Y679 448759 PQNMDVEyTEVEVSS X -Fer Fer P70451 mouse CTNNB1 12387 Q02248 Ctnnb1 mouse Y142 449044 AVVNLINyQDDAELA X -Fer Fer P70451 mouse Fer 14158 P70451 Fer mouse Y715 448461 RQEDGGVysSSGLKQ PK_Tyr_Ser-Thr X -Prkca PKCA P05696 rat INSR iso2 3643 P06213-2 INSR human T1363 450327 KKNGRILtLPRSNPS X -Prkca PKCA P05696 rat CAMK2A 25400 P11275 Camk2a rat T286 447797 sCMHRQEtVDCLkkF X 12716 -Prkca PKCA P05696 rat Tau iso8 4137 P10636-8 MAPT human T231 449079 KKVAVVRtPPKsPss X 20473; 71429 -Prkca PKCA P05696 rat GluR2 29627 P19491 Gria2 rat S697 10306402 KMWTYMRsAEPSVFV Lig_chan X -Prkca PKCA P05696 rat SNAP23 8773 O00161 SNAP23 human S23 9766096 ItDEsLEstRRILGL X -Prkca PKCA P05696 rat PLCB3 29322 Q99JE6 Plcb3 rat S1105 448448 LDRKRNNsISEAKTR PLC-beta_C X 2484 -Prkca PKCA P05696 rat GPM6A 306439 Q812E9 Gpm6a rat T10 11488702 ENMEEGQtQKGCFEC X -Prkca PKCA P05696 rat PCDHGA3 93711 Q91XY5 Pcdhga3 mouse S922 41590812 GNGNKKKsGKKEKK_ Cadherin_tail X -Prkca PKCA P05696 rat Tau iso2 4137 P10636-2 MAPT human S315 449082 PVVSGDTsPRHLsNV X 35834; 20194; 98523; 91600; 49562 -Prkca PKCA P05696 rat HES1 3280 Q14469 HES1 human S37 11424700 TAsEHRKssKPIMEK HLH X X -Prkca PKCA P05696 rat CFTR 1080 P13569 CFTR human S707 2907509 sILNPINsIRKFsIV CFTR_R X -Prkca PKCA P05696 rat RAF1 5894 P04049 RAF1 human S497 3082308 AtVksRWsGsQQVEQ PK_Tyr_Ser-Thr X -Prkca PKCA P05696 rat MARCKS 25603 P30009 Marcks rat S156 447787 KRFsFKKsFkLsGFs MARCKS X X 2741; 11992 -Prkca PKCA P05696 rat G-alpha 15 14676 P30678 Gna15 mouse S334 11380904 QDGGRKGsRARRFFA G-alpha X -Prkca PKCA P05696 rat desmin 395906 P02542 DES chicken S56 1868158501 TsAVPTLsTFRTTRV Filament_head X -Prkca PKCA P05696 rat H1C 513971 P02253 H1-2 cow S104 451806 KGTGASGsFKLNKKA Linker_histone X -Prkca PKCA P05696 rat H1R 3269 P35367 HRH1 human S398 450937 WKRLRsHsRQyVSGL 7tm_1 X -Prkca PKCA P05696 rat Tau iso6 4137 P10636-6 MAPT human S346 449082 PVVSGDTsPRHLSNV X 35834; 20194; 98523; 91600; 49562 -Prkca PKCA P05696 rat ANXA2 302 P07355 ANXA2 human S26 450879 tPPsAyGsVkAytNF X -Prkca PKCA P05696 rat GLP1R 25051 P32301 Glp1r rat S432 451367 LNIQRDssMKPLKCP X -Prkca PKCA P05696 rat desmin 395906 P02542 DES chicken S29 466347 sPVFPRAsFGSRGsG Filament_head X -Prkca PKCA P05696 rat Kv3.4 3749 Q03721 KCNC4 human S9 451076 ISSVCVssYRGRKsG Potassium_chann X -Prkca PKCA P05696 rat uPA 5328 P00749 PLAU human S158 451052 CADGKKPsSPPEELK X -Prkca PKCA P05696 rat HRas 15461 Q61411 Hras mouse S177 455374 kLNPPDEsGPGCMSC X -Prkca PKCA P05696 rat ATP1A1 24211 P06685 Atp1a1 rat S16 449086 KyEPAAVsEHGDkks X X 4020 -Prkca PKCA P05696 rat Kv2.2 117105 Q63099 Kcnb2 rat S481 15720997 ESANIKDsVDDNHLs Kv2channel X -Prkca PKCA P05696 rat CFTR 1080 P13569 CFTR human T682 2907505 APVSWTEtKKQsFKQ CFTR_R X -Prkca PKCA P05696 rat SNAP-25 25012 P60881 Snap25 rat T138 449875 GGFIRRVtNDARENE SNAP-25 X -Prkca PKCA P05696 rat uPA 5328 P00749 PLAU human S323 451053 TGFGKENsTDYLYPE Trypsin X -Prkca PKCA P05696 rat GBPI-1 54866 Q9NXH3 PPP1R14D human T58 450935 SRRPSRLtVKYDRGQ PP1_inhibitor X -Prkca PKCA P05696 rat PITPNA 29525 P16446 Pitpna rat S166 450933 EDPAkFKsIKTGRGP IP_trans X -Prkca PKCA P05696 rat Tau iso6 4137 P10636-6 MAPT human T173 449079 KKVAVVRtPPKsPSS X 20473; 71429 -Prkca PKCA P05696 rat GPM6A 306439 Q812E9 Gpm6a rat S267 456834 QELHDIHsTRSKERL X -Prkca PKCA P05696 rat CACNA1B 257648 Q02294 Cacna1b rat S896 455283 ERARPRRsHsKEAPG X -Prkca PKCA P05696 rat RKIP 29542 P31044 Pebp1 rat S153 448755 RGkFkVEsFRKKYHL PBP X X -Prkca PKCA P05696 rat Tau iso8 4137 P10636-8 MAPT human S396 449081 GAEIVyKsPVVsGDt X 9632 -Prkca PKCA P05696 rat syndecan-2 25615 P34900 Sdc2 rat S187 452068 DLGERKPssAAyQKA Syndecan X -Prkca PKCA P05696 rat MARCKS 25603 P30009 Marcks rat S163 451837 sFkLsGFsFkKSKKE MARCKS X 8722 -Prkca PKCA P05696 rat Tau iso8 4137 P10636-8 MAPT human S404 449082 PVVsGDtsPRHLsNV X 35834; 20194; 98523; 91600; 49562 -Prkca PKCA P05696 rat syndecan-2 25615 P34900 Sdc2 rat S188 452069 LGERKPssAAyQKAP Syndecan X -Prkca PKCA P05696 rat SNAP23 64630 O70377 Snap23 rat S160 4148814 ENLTQVGsILGNLKN X -Prkca PKCA P05696 rat ADCY6 25289 Q03343 Adcy6 rat S10 450817 LPVARSGsGRSSMsW X -Prkca PKCA P05696 rat Kv3.4 3749 Q03721 KCNC4 human S21 451078 KsGNKPPsKTCLKEE Potassium_chann X -Prkca PKCA P05696 rat GluR5 iso2 2897 P39086-2 GRIK1 human S885 457627 KsRTKGKsSFTSILT X -Prkca PKCA P05696 rat mGluR5 iso2 24418 P31424-2 Grm5 rat S901 4213805 QHLWQRLsVHINKKE X -Prkca PKCA P05696 rat NMDAR1 24408 P35439 Grin1 rat S897 448256 sFKRRRssKDtSTGG X -Prkca PKCA P05696 rat TNNI3 29248 P23693 Tnni3 rat S43 450690 AKKKSKIsAsRKLQL X -Prkca PKCA P05696 rat Cortactin 60465 NP_001385572 Cttn rat T145 41425400 GFEYQGktEKHASQK HS1_rep X -Prkca PKCA P05696 rat MARCKS 25603 P30009 Marcks rat S152 447786 KKKKKRFsFKKsFkL MARCKS X X 2741; 11992 -Prkca PKCA P05696 rat Tau iso5 4137 P10636-5 MAPT human T231 449079 KKVAVVRtPPKsPSS X 20473; 71429 -Prkca PKCA P05696 rat TNNI3 29248 P23693 Tnni3 rat S23 448423 PAPVRRRssANYRAY Troponin-I_N X 4004 -Prkca PKCA P05696 rat neurogranin 4900 Q92686 NRGN human S36 455913 AAAKIQAsFrGHMAR IQ X -Prkca PKCA P05696 rat PLD1 iso2 25096 P70496-2 Pld1 rat S561 448574 SRKFSKFsLYRQLHR X X -Prkca PKCA P05696 rat NMDAR2B 2904 Q13224 GRIN2B human S1323 455808 ALAPRSVsLKDKGRF NMDAR2_C X -Prkca PKCA P05696 rat Akt1 24185 P47196 Akt1 rat S473 447855 RPHFPQFsYSASGTA Pkinase_C X 9271; 3787; 4060; 4051; 5102; 4058; 2336; 2337; 4075; 4070; 5012; 4071; 92982; 5315; 9563; 9018; 12694; 52240; 11962; 15116; 88106; 26580; 68035; 31957; 23430; 20235 -Prkca PKCA P05696 rat PPP2R5D 21770 Q7TNL5 Ppp2r5d mouse S566 457390 KVLLRRKsELPQDVy X -Prkca PKCA P05696 rat GFAP 396562 F1RR02 GFAP pig S8 449618 MERRRVtsAARRsYV Filament_head X -Prkca PKCA P05696 rat MAT1A 25331 P13444 Mat1a rat T342 451384 TYGTSKKtERDELLE S-AdoMet_synt_C X -Prkca PKCA P05696 rat SNAP23 8773 O00161 SNAP23 human T24 11486600 tDEsLEstRRILGLA X -Prkca PKCA P05696 rat GIRK4 29713 P48548 Kcnj5 rat S191 450684 GCMFVKIsQPKKRAE IRK X -Prkca PKCA P05696 rat STXBP1 25558 P61765 Stxbp1 rat S306 448743 VSQEVTRsLkDFSSs Sec1 X -Prkca PKCA P05696 rat GABRG2 14406 P22723 Gabrg2 mouse S381 452033 NPLLRMFsFKAPTID Neur_chan_memb X -Prkca PKCA P05696 rat MARCKS 4082 P29966 MARCKS human S163 447787 KRFsFkKsFkLsGFs MARCKS X 2741; 11992 -Prkca PKCA P05696 rat GluR2 29627 P19491 Gria2 rat S863 455806 NPSSSQNsQNFATyk X X -Prkca PKCA P05696 rat ADD1 24170 Q63028 Add1 rat S724 449829 KKKFRTPsFLKKSKK X -Prkca PKCA P05696 rat GluR5 iso2 2897 P39086-2 GRIK1 human S879 457626 QKKIKKKsRTKGKsS X -Prkca PKCA P05696 rat Tau iso5 4137 P10636-5 MAPT human S365 449081 GAEIVYKsPVVsGDT X 9632 -Prkca PKCA P05696 rat Myf-6 25714 P19335 Myf6 rat S221 451240 SSLQRLssIVDSISS X -Prkca PKCA P05696 rat G-alpha 15 2769 P30679 GNA15 human S336 11380905 GsKKGARsRRLFSHY G-alpha X -Prkca PKCA P05696 rat HES1 3280 Q14469 HES1 human S38 3882731 AsEHRKssKPIMEKR HLH X X -Prkca PKCA P05696 rat RGS5 8490 O15539 RGS5 human S84 10773104 SFKSFLKsEFSEENL RGS X -Prkca PKCA P05696 rat p47phox 653361 P14598 NCF1 human S370 451730 PAVPPRPsADLILNR p47_phox_C X -Prkca PKCA P05696 rat SH3BP2 6452 P78314 SH3BP2 human S278 455470 PAtPRRMsDPPLStM X -Prkca PKCA P05696 rat DGKD 8527 Q16760 DGKD human S66 452137 MLTkQNNsFQRsKRR PH X X -Prkca PKCA P05696 rat DYN1 1759 Q05193 DNM1 human S795 447604 VPPARPGsRGPAPGP X -Prkca PKCA P05696 rat H2B 303175 D3ZNZ9 Hist3h2ba rat S14 449904 TPAPkkGskkAITkA Histone X 6959 -Prkca PKCA P05696 rat FSHR 25449 P20395 Fshr rat T469 451072 ITLERWHtItHAMQL 7tm_1 X -Prkca PKCA P05696 rat FSHR 25449 P20395 Fshr rat T471 451073 LERWHtItHAMQLEC 7tm_1 X -Prkca PKCA P05696 rat TRPC6 iso2 89823 Q99N77 Trpc6 rat S714 455910 VPFNLVPsPKSLLYL X -Prkca PKCA P05696 rat GluR2 29627 P19491 Gria2 rat S661 10306401 IESAEDLsKQTEIAY Lig_chan X -Prkca PKCA P05696 rat ANXA2 282689 P04272 ANXA2 cow S26 450879 TPPSAyGsVKAYTNF X -Prkca PKCA P05696 rat SNAP23 64630 O70377 Snap23 rat S95 455262 NRTKNFEsGKNYKAt SNAP-25 X -Prkca PKCA P05696 rat PSEN1 5663 P49768 PSEN1 human S346 450179 EWEAQRDsHLGPHRs Presenilin X -Prkca PKCA P05696 rat Myf-6 25714 P19335 Myf6 rat S220 451239 SSSLQRLssIVDSIS X -Prkca PKCA P05696 rat NMDAR1 24408 P35439 Grin1 rat S890 447737 ITSTLAssFKRRRss X -Prkca PKCA P05696 rat NMDAR2B 2904 Q13224 GRIN2B human S1303 450171 NKLRRQHsyDtFVDL NMDAR2_C X 20274; 71335 -Prkca PKCA P05696 rat eIF2-beta 100009285 P41035 EIF2S2 rabbit S13 454001 MIFDPTMsKKKKKKK X -Prkca PKCA P05696 rat HMGB1 3146 P09429 HMGB1 human S46 33673900 sEFskkCsERWktMs HMG_box_2 X -Prkca PKCA P05696 rat GAP43 29423 P07936 Gap43 rat S41 448719 AATkIQAsFRGHITR IQ X X -Prkca PKCA P05696 rat PODXL 192181 Q9WTQ2 Podxl rat S415 21514209 GCCHQRIsQRKDQQR CD34_antigen X -Prkca PKCA P05696 rat TRPV1 83810 O35433 Trpv1 rat S800 450017 VPLLRDAsTRDRHAT X -Prkca PKCA P05696 rat PAM 25508 P14925 Pam rat S937 450813 FASRKGYsRKGFDRV X -Prkca PKCA P05696 rat Tau iso2 4137 P10636-2 MAPT human S307 449081 GAEIVYKsPVVSGDT X 9632 -Prkca PKCA P05696 rat desmin 395906 P02542 DES chicken S38 466348 GSRGsGSsVTSRVYQ Filament_head X -Prkca PKCA P05696 rat PKCA 24680 P05696 Prkca rat S657 448597 QSDFEGFsYVNPQFV Pkinase_C X 9371 -Prkca PKCA P05696 rat CEACAM1 81613 P16573 Ceacam1 rat S503 448536 QQSKRPTsASSSPTE X -Prkca PKCA P05696 rat calponin 1 396522 P26932 CNN1 chicken T170 469593 IIGLQMGtNKFAsQQ Calponin X -Prkca PKCA P05696 rat DYN1 140694 P21575 Dnm1 rat S795 447604 VPPARPGsRGPAPGP X -Prkca PKCA P05696 rat IRS1 25467 P35570 Irs1 rat S612 447562 DDGyMPMsPGVAPVP X 3193; 2386; 3203 -Prkca PKCA P05696 rat NMDAR1 24408 P35439 Grin1 rat S896 448255 ssFKRRRssKDtSTG X X -Prkca PKCA P05696 rat ATP1A1 24211 P06685 Atp1a1 rat S23 449087 sEHGDkkskkAKKER X X 4006 -Prkca PKCA P05696 rat CFTR 1080 P13569 CFTR human T604 2907506 NKTRILVtsKMEHLK X -Prkca PKCA P05696 rat NMDAR2A 24409 Q00959 Grin2a rat S1416 455790 ASYCSRDsRGHSDVy NMDAR2_C X -Prkca PKCA P05696 rat Myf-6 25714 P19335 Myf6 rat T99 451225 TDRRKAAtLRERRRL HLH X -Prkca PKCA P05696 rat C/EBP-alpha 24252 P05554 Cebpa rat S248 449826 GLPGPGGsLKGLAGP X -Prkca PKCA P05696 rat SH3BP2 6452 P78314 SH3BP2 human S225 455469 sDMPRAHsFTsKGPG X -Prkca PKCA P05696 rat HER2 2064 P04626 ERBB2 human T686 451817 QQKIRKYtMRRLLQE X 88583 -Prkca PKCA P05696 rat Kv3.1 25327 P25122 Kcnc1 rat S503 464642 LEINRADsKLNGEVA X -Prkca PKCA P05696 rat INSR 24954 P15127 Insr rat T1376 450327 KKNGRVLtLPRSNPS X -Prkca PKCA P05696 rat Cortactin 60465 NP_001385572 Cttn rat S135 31881968 QMDRVDQsAVGFEYQ HS1_rep X -Prkca PKCA P05696 rat PLM 5348 O00168 FXYD1 human S83 451424 EEGtFRssIRRLstR X -Prkca PKCA P05696 rat TRPV1 83810 O35433 Trpv1 rat S502 450016 YFLQRRPsLKSLFVD Ion_trans X -Prkca PKCA P05696 rat Kv3.4 3749 Q03721 KCNC4 human S8 451075 MISSVCVssYRGRKs Potassium_chann X -Prkca PKCA P05696 rat NRF2 83619 O54968 Nfe2l2 rat S40 450082 SREVFDFsQRQKDYE X -Prkca PKCA P05696 rat MARCKS 4082 P29966 MARCKS human S167 466360 FkKsFkLsGFsFkKN MARCKS X 8722 -Prkca PKCA P05696 rat PITPNA 18738 P53810 Pitpna mouse S166 450933 EDPAkFKsVKTGRGP IP_trans X X -Prkca PKCA P05696 rat PLD1 iso2 25096 P70496-2 Pld1 rat S2 448572 ______MsLRSEARV X X -Prkca PKCA P05696 rat PLM 5348 O00168 FXYD1 human S88 451425 RssIRRLstRRR___ X -Prkca PKCA P05696 rat SNAP-25 25012 P60881 Snap25 rat S187 448668 RIMEkADsNkTRIDE X -Prkca PKCA P05696 rat PTPRA 19262 P18052 Ptpra mouse S204 447612 PLLARsPstNRKYPP X -Prkca PKCA P05696 rat RGS5 8490 O15539 RGS5 human S166 482845 HALMEKDsLPRFVRS RGS X -Prkca PKCA P05696 rat SNAP23 8773 O00161 SNAP23 human S161 4148814 ENLtQVGsILGNLKD X -Prkca PKCA P05696 rat PLM 58971 O08589 Fxyd1 rat S83 451424 EEGtFRSsIRRLstR X -Prkca PKCA P05696 rat GFAP 396562 F1RR02 GFAP pig S34 449621 LGPGPRLsLARMPPP Filament_head X -Prkca PKCA P05696 rat MOR-1 25601 P33535 Oprm1 rat T370 447785 sTRVRQNtREHPsTA X -Prkca PKCA P05696 rat PLM 58971 O08589 Fxyd1 rat S88 451425 RSsIRRLstRRR___ X -Prkca PKCA P05696 rat GABRG2 iso2 14406 P22723-2 Gabrg2 mouse S365 486436 FVSNRKPsKDKDKKK Neur_chan_memb X -Prkca PKCA P05696 rat GRK2 156 P25098 GRK2 human S29 447724 ATPAARAskkILLPE X -Prkca PKCA P05696 rat GJA1 24392 P08050 Gja1 rat S368 447813 QRPssRAssRAssRP X 3511; 52559 -Prkca PKCA P05696 rat SLC18A3 60422 Q62666 Slc18a3 rat S480 450965 GLLTRSRsERDVLLD X X -Prkca PKCA P05696 rat Kv3.4 3749 Q03721 KCNC4 human S15 451077 ssYRGRKsGNKPPsK Potassium_chann X -Prkca PKCA P05696 rat PITPNA 5306 Q00169 PITPNA human S165 450933 EDPAkFKsIKTGRGP IP_trans X -Prkca PKCA P05696 rat CNR1 25248 P20272 Cnr1 rat S317 450999 IQRGtQKsIIIHtSE 7tm_1 X -Prkca PKCA P05696 rat GJA1 24392 P08050 Gja1 rat S369 459208 RPssRAssRAssRPR X X -Prkca PKCA P05696 rat Tau iso5 4137 P10636-5 MAPT human S373 449082 PVVsGDTsPRHLSNV X 35834; 20194; 98523; 91600; 49562 -Prkca PKCA P05696 rat CFTR 1080 P13569 CFTR human S686 449980 WTEtKKQsFKQTGEF CFTR_R X X -Prkca PKCA P05696 rat GABRG2 29709 Q6PW52 Gabrg2 rat S381 452033 NPLLRMFsFKAPTID Neur_chan_memb X -Prkca PKCA P05696 rat ADD2 119 P35612 ADD2 human S713 449802 KKKFRtPsFLKKsKK X -Prkca PKCA P05696 rat HMGCR 25675 P51639 Hmgcr rat S871 448568 SHMVHNRsKINLQDL X -Prkca PKCA P05696 rat TREK-2 65272 Q9JIS4 Kcnk10 rat S359 465530 RETRRRLsVEIHDKL X -Prkca PKCA P05696 rat Cortactin 60465 NP_001385572 Cttn rat S172 15176497 QADRVDKsAVGFDYQ HS1_rep X -Prkca PKCA P05696 rat ADD1 118 P35611 ADD1 human S726 449829 KKKFRtPsFLKKsKK X -Prkca PKCA P05696 rat PMCA4 493 P23634 ATP2B4 human S1115 452025 NTFQTGAsFKGVLRR ATP_Ca_trans_C X -Prkca PKCA P05696 rat Tau iso6 4137 P10636-6 MAPT human S338 449081 GAEIVYKsPVVSGDT X 9632 -Prkca PKCA P05696 rat p40phox 4689 Q15080 NCF4 human T154 448266 LRRLRPRtRKVKSVs X 4311 -Prkca PKCA P05696 rat CACNA1B 257648 Q02294 Cacna1b rat S898 455281 ARPRRsHsKEAPGAD X -Prkca PKCA P05696 rat DGKD 8527 Q16760 DGKD human S70 452138 QNNsFQRsKRRYFKL PH X X -Prkca PKCA P05696 rat CD5 921 P06127 CD5 human T434 450129 MsFHRNHtAtVRsHA X -Prkca PKCA P05696 rat desmin 395906 P02542 DES chicken S12 466346 SsSQRVSsYRRTFGG Filament_head X -Prkca PKCA P05696 rat SNAP23 64630 O70377 Snap23 rat S120 455263 NVVsKQPsRITNGQP SNAP-25 X -Prkca PKCA P05696 rat HSPB8 26353 Q9UJY1 HSPB8 human S14 7994901 PFSCHYPsRLRRDPF X -Prkca PKCA P05696 rat GIRK1 50599 P63251 Kcnj3 rat S185 450683 GCMFIKMsQPKKRAE IRK X -Prkca PKCA P05696 rat PTPRA 19262 P18052 Ptpra mouse S180 447611 QAGsHSNsFRLSNGR X -Prkca PKCA P05696 rat Tau iso6 4137 P10636-6 MAPT human S177 449080 VVRtPPKsPSSAKSR X 20473 -Prkca PKCA P05696 rat PITPNA 29525 P16446 Pitpna rat T59 1305700 DGEKGQYtHKIYHLQ IP_trans X -Prkca PKCA P05696 rat TNNI3 29248 P23693 Tnni3 rat S24 448424 APVRRRssANYRAYA Troponin-I_N X 4004 -Prkca PKCA P05696 rat STXBP1 25558 P61765 Stxbp1 rat S313 448744 sLkDFSSsKRMNTGE Sec1 X X -Prkca PKCA P05696 rat Kir6.2 16514 Q61743 Kcnj11 mouse T180 450652 QAHRRAEtLIFSKHA X -Prkca PKCA P05696 rat VASP 361517 B5DEX4 Vasp rat S154 448379 EHLERRVsNAGGPPA X X 3111; 84519 -Prkca PKCA P05696 rat ATP2B2 491 Q01814 ATP2B2 human T1139 11422300 RGLNRIQtQIRVVKA ATP_Ca_trans_C X -Prkca PKCA P05696 rat mGluR1 24414 P23385 Grm1 rat T695 453089 GSKKKICtRKPRFMS 7tm_3 X -Prkca PKCA P05696 rat POLB 29240 P06766 Polb rat S44 41521700 NAYRKAAsVIAKyPH HHH_8 X -Prkca PKCA P05696 rat PLD1 iso2 25096 P70496-2 Pld1 rat T147 448573 PIPTKRHtFRRQNVK PX X X -Prkca PKCA P05696 rat RAF1 5894 P04049 RAF1 human S619 5822317 sLPKINRsAsEPsLH X -Prkca PKCA P05696 rat GFAP 396562 F1RR02 GFAP pig S13 449619 VtsAARRsYVSSLET Filament_head X -Prkca PKCA P05696 rat TREK-2 65272 Q9JIS4 Kcnk10 rat S326 465529 GDWLRVLsKKTKEEV X -Prkca PKCA P05696 rat GABRG2 14406 P22723 Gabrg2 mouse S365 486436 FVSNRkPskDkDkkk Neur_chan_memb X -Prkca PKCA P05696 rat G-gamma 12 14701 Q9DAS9 Gng12 mouse S2 447876 ______MssktAstN X -Prkca PKCA P05696 rat calcyon 192349 P58821 Caly rat S169 25687501 MPAIWGNsYRAGKEE Calcyon X -Prkca PKCA P05696 rat CFTR 1080 P13569 CFTR human S790 2907510 IHRKTTAsTRKVsLA CFTR_R X -Prkca PKCA P05696 rat HSPB8 26353 Q9UJY1 HSPB8 human T63 7994900 LsSAWPGtLRSGMVP X -Prkca PKCA P05696 rat PTGIR 5739 P43119 PTGIR human S328 450985 TPLSQLAsGRRDPRA X X -Prkca PKCA P05696 rat GLP1R 25051 P32301 Glp1r rat S431 451366 RLNIQRDssMKPLKC X -Prkca PKCA P05696 rat APP 54226 P08592 App rat S730 448200 LKKKQYtsIHHGVVE APP_amyloid X -Prkca PKCA P05696 rat Tau iso5 4137 P10636-5 MAPT human S235 449080 VVRtPPKsPSSAKSR X 20473 -Prkca PKCA P05696 rat CD5 921 P06127 CD5 human T436 450130 FHRNHtAtVRsHAEN X -Prkca PKCA P05696 rat PFKFB2 287019 P26285 PFKFB2 cow T476 465673 TPLSSSNtIRRPRNY X -Prkca PKCA P05696 rat ADD3 25230 Q62847 Add3 rat S692 452158 KKKFRTPsFLKKNKK X -Prkca PKCA P05696 rat TNNI3 29248 P23693 Tnni3 rat S45 450691 KKSKIsAsRKLQLkT X -Prkca PKCA P05696 rat SNAP23 8773 O00161 SNAP23 human S95 455262 NRTkNFEsGkAykTt SNAP-25 X -Prkca PKCA P05696 rat ADD1 118 P35611 ADD1 human S716 449828 GsPGKsPsKKKKKFR X -Prkca PKCA P05696 rat CFTR 1080 P13569 CFTR human S641 2907508 QNLQPDFsSKLMGCD CFTR_R X -Prkca PKCA P05696 rat p47phox 653361 P14598 NCF1 human S359 451729 EERQtQRsKPQPAVP p47_phox_C X -Prkca PKCA P05696 rat myogenin 17928 P12979 Myog mouse T87 451161 VDRRRAAtLREKRRL HLH X -Prkca PKCA P05696 rat Tau iso8 4137 P10636-8 MAPT human S235 449080 VVRtPPKsPssAKsR X 20473 -Prkca PKCA P05696 rat PITPNA 5306 Q00169 PITPNA human T58 1305700 DGEkGQytHkIYHLQ IP_trans X -Prkca PKCA P05696 rat C/EBP-beta 24253 P21272 Cebpb rat S240 452156 NNIAVRKsRDKAKMR bZIP_2 X -Prkca PKCA P05696 rat GABRB1 25450 P15431 Gabrb1 rat S434 450244 GRIRRRAsQLKVKIP Neur_chan_memb X -Prkca PKCA P05696 rat RNF10 50849 Q3UIW5 Rnf10 mouse S31 1868450200 SSASSGSsKGQQPPR X -Prkca PKCA P05696 rat GJA1 24392 P08050 Gja1 rat S262 450694 sPskDCGsPkyAyFN X -Prkca PKCA P05696 rat ADD2 119 P35612 ADD2 human S703 451693 GsPsKsPsKKKKKFR X -Prkca PKCA P05696 rat GluR2 29627 P19491 Gria2 rat S880 448351 yNVyGIEsVkI____ X X -Prkca PKCA P05696 rat CACNA1B 257648 Q02294 Cacna1b rat S802 469610 EERLRYAsTRHVRPD X -Prkca PKCA P05696 rat POLB 29240 P06766 Polb rat S55 41521701 KyPHKIKsGAEAKKL HHH_8 X -Prkca PKCA P05696 rat SYT1 25716 P21707 Syt1 rat T112 448549 DVKDLGKtMKDQALK X X -Prkca PKCA P05696 rat Kv2.2 117105 Q63099 Kcnb2 rat S488 15721000 sVDDNHLsPSRWKWA Kv2channel X -Rps6ka5 MSK1 Q8C050 mouse ataxin-1 20238 P54254 Atxn1 mouse S751 449110 ATRKRRWsAPETRKL X X -Rps6ka5 MSK1 Q8C050 mouse H3 360198 P68433 H3c1 mouse S10 455676 tkQTARkstGGkAPr Histone X X 9701; 9711; 9606; 3465; 3642; 3377; 3475; 3458; 5764; 47398; 8481; 8552; 53348; 29237; 66065; 43185; 64522; 52725 -Rps6ka5 MSK1 Q8C050 mouse BAD 12015 Q61337 Bad mouse S112 447860 ETRsRHssyPAGtEE Bcl-2_BAD X X 9291; 5284; 9296; 5193; 11865; 94223 -Rps6ka5 MSK1 Q8C050 mouse LKB1 20869 Q9WTK7 Stk11 mouse S431 448147 sNKIRRLsACKQQ__ X 3482 -Rps6ka5 MSK1 Q8C050 mouse STAT3 20848 P42227 Stat3 mouse S727 448191 NtIDLPMsPRTLDSL X X 9134; 9136; 34911; 94994; 49081; 58978; 87544; 71958; 50804 -Rps6ka5 MSK1 Q8C050 mouse HMGN1 15312 P18608 Hmgn1 mouse S20 454111 kAEPKRRsARLsAkP HMG14_17 X -Rps6ka5 MSK1 Q8C050 mouse NFkB-p65 19697 Q04207 Rela mouse S276 447798 SMQLRRPsDRELSEP RHD_dimer X -Rps6ka5 MSK1 Q8C050 mouse H3 iso3 15081 P84244 H3f3b mouse S10 455676 tKQTARksTGGkAPR Histone X 9701; 9711; 9706; 3465; 3642; 3377; 3475; 3458; 5764; 47398; 8481; 8552; 53348; 29237; 66065; 43185; 64522; 52725 -Rps6ka5 MSK1 Q8C050 mouse H3 360198 P68433 H3c1 mouse S28 455677 ATkAArksAPATGGV Histone X X 9713 -Rps6ka5 MSK1 Q8C050 mouse PLA2G4A 18783 P47713 Pla2g4a mouse S726 447599 RQNPsRCsVsLsNVE X -Rps6ka5 MSK1 Q8C050 mouse HMGN1 15312 P18608 Hmgn1 mouse S7 465531 _MPKRKVsADGAAkA HMG14_17 X -Rps6ka5 MSK1 Q8C050 mouse HMGN1 15312 P18608 Hmgn1 mouse S24 454112 KRRsARLsAkPAPAk HMG14_17 X -CDK10 CDK10 Q15131 human Ets-2 2114 P15036 ETS2 human S220 30320500 PKGGLLDsMCPAstP X -CDK10 CDK10 Q15131 human Ets-2 2114 P15036 ETS2 human S225 30320501 LDsMCPAstPsVLSS X -PRKDC DNAPK P78527 human Oct1 5451 P14859 POU2F1 human S92 483941 sQPsQQPsVQAAIPQ X -PRKDC DNAPK P78527 human hnRNP P2 2521 P35637 FUS human T19 179463707 QSYGAYPtQPGQGYs X -PRKDC DNAPK P78527 human Artemis 64421 Q96SD1 DCLRE1C human S503 466574 NDEITDEsLENFPSS X -PRKDC DNAPK P78527 human MCC 4163 P23508 MCC human S120 3624826 LRsELsQsQHEVNED X -PRKDC DNAPK P78527 human Oct4 5460 Q01860 POU5F1 human S93 25236708 PQGGLEtsQPEGEAG X X -PRKDC DNAPK P78527 human IRF3 3661 Q14653 IRF3 human T135 477901 GGGSTSDtQEDILDE X X -PRKDC DNAPK P78527 human Oct1 5451 P14859 POU2F1 human T226 483948 LQAQNLLtQLPQQsQ X -PRKDC DNAPK P78527 human XRCC4 7518 Q13426 XRCC4 human S327 3195416 sLEtLRNssPEDLFD XRCC4 X -PRKDC DNAPK P78527 human WRN 7486 Q14191 WRN human S319 14823400 SNNLNLLsFEDSTTG X -PRKDC DNAPK P78527 human XRCC4 7518 Q13426 XRCC4 human S304 3238501 ENsRPDSsLPETSKK XRCC4 X -PRKDC DNAPK P78527 human p53 7157 P04637 TP53 human S37 447532 NVLsPLPsQAMDDLM TAD2 X 9289 -PRKDC DNAPK P78527 human POLL 27343 Q9UGP5 POLL human T204 62925702 EASDGEEtQVSAADL X -PRKDC DNAPK P78527 human XPA 7507 P23025 XPA human S196 460698 RSLEVWGsQEALEEA X -PRKDC DNAPK P78527 human hnRNP P2 2521 P35637 FUS human S42 3306333 QQSYSGYsQSTDTSG X -PRKDC DNAPK P78527 human Oct1 5451 P14859 POU2F1 human S78 483937 QSKSNEEsGDsQQPs X -PRKDC DNAPK P78527 human IGFBP3 3486 P17936 IGFBP3 human S183 471397 KKGHAKDsQRYKVDy X -PRKDC DNAPK P78527 human WRN 7486 Q14191 WRN human S440 3196118 DTsYVIEsDEDLEME X X -PRKDC DNAPK P78527 human HSP90A 3320 P07900 HSP90AA1 human T7 448320 _MPEEtQtQDQPMEE X 3488 -PRKDC DNAPK P78527 human Ku80 7520 P13010 XRCC5 human S580 452072 GAHFsVSsLAEGsVT X -PRKDC DNAPK P78527 human H2AX 3014 P16104 H2AX human T136 455687 PsGGkkAtQAsQEy_ X X -PRKDC DNAPK P78527 human Oct1 5451 P14859 POU2F1 human T100 483942 VQAAIPQtQLMLAGG X -PRKDC DNAPK P78527 human hnRNP U 3192 Q00839 HNRNPU human S59 468001 AMEPGNGsLDLGGDs X X -PRKDC DNAPK P78527 human RFA2 6118 P15927 RPA2 human S29 448338 QsPGGFGsPAPsQAE X -PRKDC DNAPK P78527 human p53 7157 P04637 TP53 human S9 447538 EEPQsDPsVEPPLsQ P53_TAD X 9288 -PRKDC DNAPK P78527 human fumarase 2271 P07954 FH human T236 49156200 IkIGRTHtQDAVPLT Lyase_1 X X -PRKDC DNAPK P78527 human Pnk1 11284 Q96T60 PNKP human S114 460832 EEtRtPEsQPDtPPG X 3522 -PRKDC DNAPK P78527 human Oct1 5451 P14859 POU2F1 human T162 483946 ASAATPMtQIPLsQP X -PRKDC DNAPK P78527 human p53 7157 P04637 TP53 human S46 447536 AMDDLMLsPDDIEQW TAD2 X 2521 -PRKDC DNAPK P78527 human HOXA11 3207 P31270 HOXA11 human T119 55571506 ANVYHHPtPAVSSNF DUF3528 X -PRKDC DNAPK P78527 human SRF 6722 P11831 SRF human S446 449956 STMQVSHsQVQEPGG X -PRKDC DNAPK P78527 human p53 7157 P04637 TP53 human T18 447541 EPPLsQEtFsDLWkL P53_TAD X 2529 -PRKDC DNAPK P78527 human Akt1 207 P31749 AKT1 human S473 447855 RPHFPQFsysAsGtA Pkinase_C X X 9271; 3787; 4060; 4051; 5102; 4058; 2336; 2337; 4075; 4070; 5012; 4071; 92982; 5315; 9563; 9018; 12694; 52240; 11962; 15116; 88106; 26580; 68035; 31957; 23430; 20235 -PRKDC DNAPK P78527 human Ku70 2547 P12956 XRCC6 human S6 452070 __MsGWEsyykTEGD X -PRKDC DNAPK P78527 human SOX2 6657 P48431 SOX2 human S251 6738002 VksEAsssPPVVtSS X X 92186 -PRKDC DNAPK P78527 human hnRNP P2 2521 P35637 FUS human S131 3306337 QPQSGSYsQQPSYGG X -PRKDC DNAPK P78527 human Sin1 79109 Q9BPZ7 MAPKAP1 human S186 27458520 VYLPLHssQDRLLPM CRIM X X -PRKDC DNAPK P78527 human hnRNP P2 2521 P35637 FUS human S30 179463702 QGYsQQSsQPYGQQS X X -PRKDC DNAPK P78527 human FOXA2 P32182 Foxa2 rat S283 8046508 TAPGTQAsQVQLGEA X -PRKDC DNAPK P78527 human Artemis 64421 Q96SD1 DCLRE1C human S553 460664 QGsQGWDsQSDTVLL X -PRKDC DNAPK P78527 human GOLPH3 64083 Q9H4A6 GOLPH3 human T148 31834910 KEtQPPEtVQNWIEL GPP34 X X -PRKDC DNAPK P78527 human WRN 7486 Q14191 WRN human S467 3196124 DTsYVIEsDEDLEME X X -PRKDC DNAPK P78527 human hnRNP P2 2521 P35637 FUS human T68 179463704 sQNTGYGtQSTPQGY X -PRKDC DNAPK P78527 human NHEJ1 79840 Q9H9Q4 NHEJ1 human S55 4084907 QVDTSVVsQRAKELN XLF X -PRKDC DNAPK P78527 human Oct1 5451 P14859 POU2F1 human S167 483947 PMtQIPLsQPIQIAQ X -PRKDC DNAPK P78527 human SRF 6722 P11831 SRF human S435 449955 LTVLNAFsQAPSTMQ X -PRKDC DNAPK P78527 human Artemis 64421 Q96SD1 DCLRE1C human S645 457531 NLSTNADsQsssDFE X X -PRKDC DNAPK P78527 human RFA2 6118 P15927 RPA2 human S4 470082 ____MWNsGFEsyGs X -PRKDC DNAPK P78527 human EGR1 1958 P18146 EGR1 human S301 11423702 AFATQSGsQDLKALN X X -PRKDC DNAPK P78527 human IKKG 8517 Q9Y6K9 IKBKG human S43 449037 PAMLHLPsEQGAPEt X X -PRKDC DNAPK P78527 human Oct1 5451 P14859 POU2F1 human S85 483939 sGDsQQPsQPsQQPs X -PRKDC DNAPK P78527 human OBFC2B 79035 Q9BQ15 NABP2 human S134 25302960 NDSNPSAsQPTTGPS X X -PRKDC DNAPK P78527 human hnRNP U iso2 3192 Q00839-2 HNRNPU human S59 468001 AMEPGNGsLDLGGDS X -PRKDC DNAPK P78527 human LIG4 3981 P49917 LIG4 human T650 454069 HLkAPNLtNVNKISN X -PRKDC DNAPK P78527 human Vimentin 7431 P08670 VIM human S459 470128 GQVINEtsQHHDDLE X -PRKDC DNAPK P78527 human DNAPK 5591 P78527 PRKDC human T3950 473573 GHAFGSAtQFLPVPE PI3_PI4_kinase X X -PRKDC DNAPK P78527 human Sin1 79109 Q9BPZ7 MAPKAP1 human S367 56676494 DGVFEEDsQIDIATV X X -PRKDC DNAPK P78527 human Ku80 7520 P13010 XRCC5 human S577 452071 EQGGAHFsVSsLAEG X -PRKDC DNAPK P78527 human Oct1 5451 P14859 POU2F1 human S81 483938 SNEEsGDsQQPsQPs X -PRKDC DNAPK P78527 human XRCC1 7515 P18887 XRCC1 human S371 458811 FANtPKysQVLGLGG BRCT X -PRKDC DNAPK P78527 human PELP1 27043 Q8IZL8 PELP1 human S1033 472322 LAPEALPsQGEVERE X -PRKDC DNAPK P78527 human Vimentin 7431 P08670 VIM human S430 470126 LREtNLDsLPLVDtH X -PRKDC DNAPK P78527 human Oct1 5451 P14859 POU2F1 human S232 483949 LtQLPQQsQANLLQS X -PRKDC DNAPK P78527 human hnRNP P2 2521 P35637 FUS human T11 179463706 NDYtQQAtQSYGAYP X -PRKDC DNAPK P78527 human p53 22059 P02340 Tp53 mouse S7 448716 _MTAMEEsQsDIsLE X -PRKDC DNAPK P78527 human XRCC4 7518 Q13426 XRCC4 human S320 475981 HISAENMsLEtLRNs XRCC4 X X -PRKDC DNAPK P78527 human RAG2 5897 P55895 RAG2 human S365 482844 EQTTFTNsQTSTEDP RAG2 X -PRKDC DNAPK P78527 human Ku70 2547 P12956 XRCC6 human S51 10211800 AsKAMFEsQsEDELT Ku_N X -PRKDC DNAPK P78527 human Ku80 7520 P13010 XRCC5 human T715 452073 KDkPsGDtAAVFEEG X -PRKDC DNAPK P78527 human PDX1 3651 P52945 PDX1 human T11 456815 EEQYYAAtQLYKDPC X -PRKDC DNAPK P78527 human USF1 22278 Q61069 Usf1 mouse S262 7367003 RQSNHRLsEELQGLD X X -PRKDC DNAPK P78527 human DNAPK 5591 P78527 PRKDC human T2638 448712 VAGQIRAtQQQHDFt DNAPKcs_CC5 X -PRKDC DNAPK P78527 human GR 24413 P06536 Nr3c1 rat S527 452135 QQATAGVsQDTSENP X -PRKDC DNAPK P78527 human TOP1 7150 P11387 TOP1 human S10 465604 GDHLHNDsQIEADFR X -PRKDC DNAPK P78527 human p53 22059 P02340 Tp53 mouse S18 447490 IsLELPLsQEtFsGL P53_TAD X 9284; 9286; 12571; 56979 -PRKDC DNAPK P78527 human DNAPK 5591 P78527 PRKDC human T2609 448710 LtPMFVEtQAsQGtL DNAPKcs_CC5 X X -PRKDC DNAPK P78527 human Oct1 5451 P14859 POU2F1 human S147 483945 HsAsQQHsAAGATIS X -PRKDC DNAPK P78527 human hnRNP P2 2521 P35637 FUS human S54 283458502 TSGYGQSsYSSYGQs X -PRKDC DNAPK P78527 human Ku70 2547 P12956 XRCC6 human S27 449267 QEENLEAsGDykYsG X -PRKDC DNAPK P78527 human FIS1 66437 Q9CQ92 Fis1 mouse T34 1876807204 AGsVSKStQFEYAWC Fis1_TPR_N X -PRKDC DNAPK P78527 human Sin1 79109 Q9BPZ7 MAPKAP1 human S343 1876127002 DLDSTLEsQSAWEFC X X -PRKDC DNAPK P78527 human Pnk1 11284 Q96T60 PNKP human S126 460833 PPGtPLVsQDEKRDA X X -PRKDC DNAPK P78527 human hnRNP P2 2521 P35637 FUS human S142 283458501 SYGGQQQsYGQQQSY X -PRKDC DNAPK P78527 human Artemis 64421 Q96SD1 DCLRE1C human S516 460660 SSTVAGGsQsPKLFS X X -PRKDC DNAPK P78527 human NHEJ1 79840 Q9H9Q4 NHEJ1 human T266 4084902 QLVssAPtLsAPEKE X -PRKDC DNAPK P78527 human H1C 3006 P16403 H1-2 human T146 9765189 KkAAGGAtPkKSAKK X X -PRKDC DNAPK P78527 human PGC-1 alpha 10891 Q9UBK2 PPARGC1A human S636 15422179 SRRPRyDsYEEYQHE X -PRKDC DNAPK P78527 human p27Kip1 1027 P46527 CDKN1B human S140 481797 PkTDPSDsQTGLAEQ X -PRKDC DNAPK P78527 human XPA 7507 P23025 XPA human S173 460697 VKkNPHHsQWGDMKL XPA_C X -PRKDC DNAPK P78527 human Oct4 5460 Q01860 POU5F1 human S111 25236703 EsNsDGAsPEPCtVt X -PRKDC DNAPK P78527 human NFkB-p105 4790 P19838 NFKB1 human S20 18751700 QMFHLDPsLTHTIFN X -PRKDC DNAPK P78527 human DNAPK 5591 P78527 PRKDC human T2647 448713 QQHDFtLtQTADGRs DNAPKcs_CC5 X X -PRKDC DNAPK P78527 human Artemis 64421 Q96SD1 DCLRE1C human S548 460663 THITEQGsQGWDsQS X -PRKDC DNAPK P78527 human MCC 4163 P23508 MCC human S118 3624820 SELRsELsQsQHEVN X -PRKDC DNAPK P78527 human DNAPK 5591 P78527 PRKDC human S2612 448711 MFVEtQAsQGtLQtR DNAPKcs_CC5 X -PRKDC DNAPK P78527 human YB-1 4904 P67809 YBX1 human T89 36130583 EDVFVHQtAIkkNNP CSD X X -PRKDC DNAPK P78527 human POLR2A 5430 P24928 POLR2A human S1616 450204 TPQSPSysPtsPsYS RNA_pol_Rpb1_R X 4735; 13499; 13546; 31262 -PRKDC DNAPK P78527 human MED1 5469 Q15648 MED1 human T1457 449866 HsKsPAytPQNLDsE X -PRKDC DNAPK P78527 human RFA2 6118 P15927 RPA2 human S8 470083 MWNsGFEsyGsssyG X 83745; 54762; 31912; 47711 -PRKDC DNAPK P78527 human ASF1A 25842 Q9Y294 ASF1A human S192 12671900 GWSTSENsLNVMLES X -PRKDC DNAPK P78527 human HSP90A 3320 P07900 HSP90AA1 human T5 448319 ___MPEEtQtQDQPM X 3488 -PRKDC DNAPK P78527 human hnRNP P2 2521 P35637 FUS human S84 3306336 STGGYGSsQSsQSSY X -PRKDC DNAPK P78527 human AIRE 326 O43918 AIRE human T68 1191300 ALLSWLLtQDSTAIL HSR X -PRKDC DNAPK P78527 human p53 24842 P10361 Tp53 rat S15 447490 MsIELPLsQEtFsCL P53_TAD X 9284; 9286; 12571; 56979 -PRKDC DNAPK P78527 human HOXA11 3207 P31270 HOXA11 human S98 55571505 RDCLQAPsAAGVPGD DUF3528 X -PRKDC DNAPK P78527 human RFA2 6118 P15927 RPA2 human S33 448339 GFGsPAPsQAEkkSR X 10148 -PRKDC DNAPK P78527 human p53 7157 P04637 TP53 human S20 447529 PLsQEtFsDLWkLLP P53_TAD X 9287 -PRKDC DNAPK P78527 human hnRNP P2 2521 P35637 FUS human S117 179463708 SGsYGSSsQSSSYGQ X -PRKDC DNAPK P78527 human AIRE 326 O43918 AIRE human S156 1191301 RGTASPGsQLKAKPP X -PRKDC DNAPK P78527 human AMPKG1 5571 P54619 PRKAG1 human T284 1827354810 LKCYLHEtLETIINR CBS X X -PRKDC DNAPK P78527 human RFA2 6118 P15927 RPA2 human S23 448337 GAGGYtQsPGGFGsP X -PRKDC DNAPK P78527 human NHEJ1 79840 Q9H9Q4 NHEJ1 human S263 4084903 QPEQLVssAPtLsAP X -PRKDC DNAPK P78527 human hnRNP P2 2521 P35637 FUS human S61 3306334 sYSSYGQsQNTGYGt X -PRKDC DNAPK P78527 human hnRNP P2 2521 P35637 FUS human S26 3306335 tQPGQGYsQQSsQPY X X -PRKDC DNAPK P78527 human GOLPH3 64083 Q9H4A6 GOLPH3 human T143 31834909 ALkHVKEtQPPEtVQ GPP34 X X -PRKDC DNAPK P78527 human Artemis 64421 Q96SD1 DCLRE1C human S538 460662 HISsQNSsQSTHITE X -PRKDC DNAPK P78527 human XRCC4 7518 Q13426 XRCC4 human S260 475982 KDDsIIssLDVtDIA XRCC4 X X -PRKDC DNAPK P78527 human Oct1 5451 P14859 POU2F1 human S141 483943 AAAVQQHsAsQQHsA X -PRKDC DNAPK P78527 human XRCC4 7518 Q13426 XRCC4 human S328 3195419 LEtLRNssPEDLFDE XRCC4 X -PRKDC DNAPK P78527 human DNAPK 5591 P78527 PRKDC human S3205 452351 tPLPEDNsMNVDQDG FAT X -PRKDC DNAPK P78527 human POLR2A 5430 P24928 POLR2A human S1621 3439802 SysPtsPsYSPTSPS RNA_pol_Rpb1_R X 13780 -PRKDC DNAPK P78527 human TIF1B 10155 Q13263 TRIM28 human S824 460839 LPGAGLssQELsGGP X 4127 -PRKDC DNAPK P78527 human Chk2 11200 O96017 CHEK2 human T68 447491 SsLEtVstQELYsIP X X 2197; 2661; 28130; 12812; 82263; 64180; 59068 -PRKDC DNAPK P78527 human Ku70 2547 P12956 XRCC6 human S33 50247606 AsGDykYsGRDsLIF X -PRKDC DNAPK P78527 human CASP2 835 P42575 CASP2 human S139 6835500 LSCDYDLsLPFPVCE X X -PRKDC DNAPK P78527 human RFA2 6118 P15927 RPA2 human T21 448340 yGGAGGYtQsPGGFG X X -PRKDC DNAPK P78527 human H2AX 3014 P16104 H2AX human S139 448841 GkkAtQAsQEy____ X X 2577; 9719; 9720; 9718; 4309; 5763; 5438; 93629; 80312; 20304; 85410; 97148; 60566; 59141 -PRKDC DNAPK P78527 human TGM2 7052 P21980 TGM2 human T162 1874101934 ERQEyVLtQQGFIYQ X -PRKDC DNAPK P78527 human AMPKG1 5571 P54619 PRKAG1 human S192 1827354809 KPEFMSKsLEELQIG CBS X X -PRKDC DNAPK P78527 human hnRNP P2 2521 P35637 FUS human S87 179463703 GYGSsQSsQSSYGQQ X -PRKDC DNAPK P78527 human NHEJ1 79840 Q9H9Q4 NHEJ1 human S251 4084900 AsLQGIDsQCVNQPE X -PRKDC DNAPK P78527 human ZIC2 22772 Q62520 Zic2 mouse S200 1783002 EQYRQVAsPRTDPYS X -PRKDC DNAPK P78527 human Chk2 11200 O96017 CHEK2 human T387 447552 LMRtLCGtPtyLAPE Pkinase X -PRKDC DNAPK P78527 human Oct1 5451 P14859 POU2F1 human S88 483940 sQQPsQPsQQPsVQA X -PRKDC DNAPK P78527 human p53 7157 P04637 TP53 human S15 447490 PsVEPPLsQEtFsDL P53_TAD X X 4030; 9235; 9284; 9286; 8695; 8514; 82530; 56979 -PRKDC DNAPK P78527 human NHEJ1 79840 Q9H9Q4 NHEJ1 human S245 4084901 PHTSNSAsLQGIDsQ X X -PRKDC DNAPK P78527 human Oct1 5451 P14859 POU2F1 human S143 483944 AVQQHsAsQQHsAAG X -PRKDC DNAPK P78527 human TDP1 55775 Q9NUW8 TDP1 human S81 11279401 PKRQKsGsQEDLGWC X X -PRKDC DNAPK P78527 human USF1 7391 P22415 USF1 human S262 7367003 RQSNHRLsEELQGLD X -PRKDC DNAPK P78527 human PARP1 142 P09874 PARP1 human T594 1876872802 RSWGRVGtVIGSNkL WGR X -PRKDC DNAPK P78527 human NHEJ1 79840 Q9H9Q4 NHEJ1 human T223 4084906 DLYMAVTtQEVQVGQ X -PRKDC DNAPK P78527 human DNAPK 5591 P78527 PRKDC human S2056 455794 VQsYsYSsQDPRPAT DNAPKcs_CC3 X X 68716 -PRKDC DNAPK P78527 human NHEJ1 79840 Q9H9Q4 NHEJ1 human S132 4084905 LASPSLVsQHLIRPL XLF X -PRKDC DNAPK P78527 human VCP 7415 P55072 VCP human S784 456210 NQGGAGPsQGsGGGt X -PRKDC DNAPK P78527 human Artemis 64421 Q96SD1 DCLRE1C human S534 460661 GESTHISsQNSsQST X -PRKDC DNAPK P78527 human PNPT1 87178 Q8TCS8 PNPT1 human S776 482067 IVMGEPIsQSSSNsQ X X -PRKDC DNAPK P78527 human Vimentin 7431 P08670 VIM human S56 451514 srsLyAssPGGVyAt Filament_head X 3877; 7391 -PRKDC DNAPK P78527 human Chk2 11200 O96017 CHEK2 human T383 447545 GEtsLMRtLCGtPty Pkinase X -PRKDC DNAPK P78527 human Akt1 207 P31749 AKT1 human T308 447856 kDGAtMKtFCGtPEy Pkinase X 5106; 2965; 9275; 4056; 5056; 13842; 13038; 43506; 48646; 86758; 80722; 77440; 80556 -PRKDC DNAPK P78527 human hnRNP P2 2521 P35637 FUS human T7 179463705 _MASNDYtQQAtQSY X -PRKDC DNAPK P78527 human hnRNP P2 2521 P35637 FUS human S112 283458500 APSSTSGsYGSSsQS X -Erbb2 HER2 P06494 rat HER2 24337 P06494 Erbb2 rat Y1250 447614 PTAENPEyLGLDVPV X 2247 -Erbb2 HER2 P06494 rat HER2 24337 P06494 Erbb2 rat Y1223 449744 SPAFDNLyyWDQNSS X -Erbb2 HER2 P06494 rat HER2 24337 P06494 Erbb2 rat Y1198 448676 GAVENPEyLVPREGT X -Erbb2 HER2 P06494 rat HER2 24337 P06494 Erbb2 rat Y1224 448675 PAFDNLyyWDQNSSE X -Erbb2 HER2 P06494 rat PTPRE 19267 P49446 Ptpre mouse Y695 450705 FIDIFSDyANFK___ X -Erbb2 HER2 P06494 rat HER2 24337 P06494 Erbb2 rat Y1141 448678 ACSPQPEyVNQSEVQ X -RIOK3 RIOK3 O14730 human MDA5 64135 Q9BYX4 IFIH1 human S828 40587800 GRARADEsTYVLVAH X X -MAP3K12 DLK Q12852 human H3 291159 Q6LED0 Hist1h2ail1 rat T11 455680 kQTARkstGGkAPRk Histone X X 9767; 9764 -MAP3K12 DLK Q12852 human MRLC2 103910 O14950 MYL12B human S20 448595 KRPQRAtsNVFAMFD X -MAP3K12 DLK Q12852 human MRLC2 103910 O14950 MYL12B human T19 448596 KKRPQRAtsNVFAMF X -Pink1 PINK1 Q99MQ3 mouse UBB 22187 P0CG49 Ubb mouse S65 40515012 DYNIQkEsTLHLVLR ubiquitin X -Pink1 PINK1 Q99MQ3 mouse XBP1 22433 O35426 Xbp1 mouse S61 21688102 RQRLTHLsPEEKALR bZIP_1 X -Pink1 PINK1 Q99MQ3 mouse LETM1 3954 O95202 LETM1 human T192 384464302 ILNGHsLtRRERRQF LETM1_RBD X -Pink1 PINK1 Q99MQ3 mouse XBP1 22433 O35426 Xbp1 mouse T48 21688103 AGSEASGtPQARKRQ X X -Pink1 PINK1 Q99MQ3 mouse ubiquitin P62991 UBA52-RPS27A-UBB-UBC mouse S65 9765472 DYNIQkEstLHLVLR ubiquitin X X 43163; 37642; 62802; 70973; 83816; 88503 -PKN1 PKN1 Q16512 human Tau iso8 4137 P10636-8 MAPT human S352 487459 DFKDrVQskIGsLDN Tubulin-binding X -PKN1 PKN1 Q16512 human MARCKS 17118 P26645 Marcks mouse S163 451837 sFkLsGFsFKKsKKE MARCKS X 8722 -PKN1 PKN1 Q16512 human Tau iso8 4137 P10636-8 MAPT human S320 450139 VDLskVtskCGsLGN Tubulin-binding X X -PKN1 PKN1 Q16512 human EGFR 1956 P00533 EGFR human T678 448053 RHIVRKRtLRRLLQE X X 14343 -PKN1 PKN1 Q16512 human HDAC5 10014 Q9UQL6 HDAC5 human T292 13204426 KDGtVIstFKKRAVE X -PKN1 PKN1 Q16512 human H3 8350 P68431 H3C1 human T11 455680 kQtArkstGGkAPrk Histone X X 9767; 9764 -PKN1 PKN1 Q16512 human MARCKS 17118 P26645 Marcks mouse S152 447786 kkKKKRFsFKKsFkL MARCKS X 2741; 11992 -PKN1 PKN1 Q16512 human Tau iso8 4137 P10636-8 MAPT human S258 487453 PDLkNVKskIGstEN Tubulin-binding X -PKN1 PKN1 Q16512 human TRAF1 22029 P39428 Traf1 mouse S139 26331402 MALERNLsELQLQAA X -PKN1 PKN1 Q16512 human Tau iso8 4137 P10636-8 MAPT human S214 447929 GsRsRtPsLPtPPtR X 77348 -PKN1 PKN1 Q16512 human HDAC9 9734 Q9UKV0 HDAC9 human S253 13204427 KDGNVVTsFKKRMFE X -PKN1 PKN1 Q16512 human MARCKS 17118 P26645 Marcks mouse S156 447787 KRFsFKKsFkLsGFs MARCKS X 2741; 11992 -PKN1 PKN1 Q16512 human pyrin 4210 O15553 MEFV human S208 455897 VRLRRNAssAGRLQG X X -PKN1 PKN1 Q16512 human Restin 6249 P30622 CLIP1 human S312 4769833 AsLKRsPsAssLsSM X -PKN1 PKN1 Q16512 human PKN1 5585 Q16512 PKN1 human T774 447835 GyGDRtstFCGtPEF Pkinase X 2611 -PKN1 PKN1 Q16512 human pyrin 4210 O15553 MEFV human S242 455899 SGKMRPRsLEVTIST X X -Wnk1 WNK1 P83741 mouse OSR1 108737 Q6P9R2 Oxsr1 mouse S325 456504 VRRVPGssGRLHKtE X -Wnk1 WNK1 P83741 mouse OSR1 108737 Q6P9R2 Oxsr1 mouse T185 456503 TRNKVRKtFVGtPCW Pkinase X -SMG1 SMG1 Q96Q15 human RENT1 5976 Q92900 UPF1 human T28 21560213 AELLGADtQGsEFEF X X -SMG1 SMG1 Q96Q15 human RENT1 5976 Q92900 UPF1 human S1089 12559503 GLsQPELsQDSYLGD X X -SMG1 SMG1 Q96Q15 human RENT1 19704 Q9EPU0 Upf1 mouse T28 21560213 AELLGADtQGSEFEF X -SMG1 SMG1 Q96Q15 human RENT1 5976 Q92900 UPF1 human S1127 460825 HGGVTGLsQy_____ X -SMG1 SMG1 Q96Q15 human RENT1 5976 Q92900 UPF1 human S1107 456314 sQIDVALsQDstyQG X X 84283 -SMG1 SMG1 Q96Q15 human RENT1 5976 Q92900 UPF1 human S1084 12559504 QMSQPGLsQPELsQD X -SMG1 SMG1 Q96Q15 human p53 7157 P04637 TP53 human S15 447490 PsVEPPLsQEtFsDL P53_TAD X 4030; 9235; 9284; 9286; 8695; 8514; 82530; 56979 -MAP3K6 MEKK6 O95382 human JNK1 5599 P45983 MAPK8 human Y185 447645 tsFMMtPyVVtRYYR Pkinase X 5136; 4668; 4671; 9257; 9255; 9251; 4306; 5755; 16014; 58328 -MAP3K6 MEKK6 O95382 human ASK1 26408 O35099 Map3k5 mouse T845 448394 GINPCtEtFTGtLQY Pkinase X 3765 -MAP3K6 MEKK6 O95382 human JNK1 5599 P45983 MAPK8 human T183 447643 AGtsFMMtPyVVtRY Pkinase X 5136; 4668; 4671; 9257; 9255; 9251; 4306; 5755; 16014; 58328 -MAP3K6 MEKK6 O95382 human MEKK6 9064 O95382 MAP3K6 human T806 7444883 GItPCTEtFTGTLQY Pkinase X X -MAP3K6 MEKK6 O95382 human P38A 1432 Q16539 MAPK14 human T180 447970 RHtDDEMtGyVAtRW Pkinase X 9211; 9215; 4551; 9216; 4552; 4631; 4511; 4092; 9219; 24678; 8632; 6908; 41768; 51255; 14594; 14598; 62979 -MAP3K6 MEKK6 O95382 human P38A 1432 Q16539 MAPK14 human Y182 447971 tDDEMtGyVAtRWYR Pkinase X 9211; 9215; 4551; 9216; 4552; 4631; 4511; 4092; 9219; 24678; 8632; 6908; 41768; 51255; 14594; 14598; 62979 -DAPK1 DAPK1 P53355 human RIGI 23586 O95786 RIGI human S654 63044902 IEGNPkLsFLkPGIL Helicase_C X -DAPK1 DAPK1 P53355 human CAMKK2 10645 Q96RR4 CAMKK2 human S511 2861414 RREERsLsAPGNLLT X X 12818 -DAPK1 DAPK1 P53355 human HSF1 3297 Q00613 HSF1 human S230 448072 PkYSRQFsLEHVHGS X X -DAPK1 DAPK1 P53355 human p53 7157 P04637 TP53 human T18 447541 EPPLsQEtFsDLWkL P53_TAD X 2529 -DAPK1 DAPK1 P53355 human PIN1 5300 Q13526 PIN1 human S71 18710000 HsQSRRPssWRQEKI Rotamase X X -DAPK1 DAPK1 P53355 human PIN1 23988 Q9QUR7 Pin1 mouse S73 18710000 HSQSRRPsSWRQEKI Rotamase X -DAPK1 DAPK1 P53355 human DAPK1 1612 P53355 DAPK1 human S289 457379 QALSRKAsAVNMEkF X -DAPK1 DAPK1 P53355 human RIGI 23586 O95786 RIGI human T671 63044901 RGktNQNtGMtLPAQ Helicase_C X -DAPK1 DAPK1 P53355 human DAPK1 69635 Q80YE7 Dapk1 mouse S308 448142 ARKKWKQsVRLISLC X -DAPK1 DAPK1 P53355 human p53 7157 P04637 TP53 human S269 17677100 GNLLGRNsFEVRVCA P53 X -DAPK1 DAPK1 P53355 human TPM1 7168 P09493 TPM1 human S283 451804 HALNDMtsI______ Tropomyosin X X -DAPK1 DAPK1 P53355 human NMDAR2B 2904 Q13224 GRIN2B human S1303 450171 NKLRRQHsyDtFVDL NMDAR2_C X 20274; 71335 -DAPK1 DAPK1 P53355 human RIGI 23586 O95786 RIGI human S764 63044903 kEkMMNDsILRLQtW X -DAPK1 DAPK1 P53355 human DAPK1 1612 P53355 DAPK1 human S308 448142 ARKKWkQsVRLISLC X X -DAPK1 DAPK1 P53355 human RIGI 23586 O95786 RIGI human T770 17484200 DsILRLQtWDEAVFR X -DAPK1 DAPK1 P53355 human RPL13A 23521 P40429 RPL13A human S77 5594501 PYHFrAPsRIFWRTV Ribosomal_L13 X -DAPK1 DAPK1 P53355 human MRLC2 103910 O14950 MYL12B human S20 448595 KRPQRAtsNVFAMFD X -DAPK1 DAPK1 P53355 human RIGI 23586 O95786 RIGI human S8 12613701 MTTEQRRsLQAFQDY CARD_2 X -DAPK1 DAPK1 P53355 human beclin 1 8678 Q14457 BECN1 human T119 6406000 LSRRLkVtGDLFDIM BH3 X X -DAPK1 DAPK1 P53355 human p53 7157 P04637 TP53 human S20 447529 PLsQEtFsDLWkLLP P53_TAD X X 9287 -DAPK1 DAPK1 P53355 human RIGI 23586 O95786 RIGI human T674 63044904 tNQNtGMtLPAQkCI Helicase_C X -DAPK1 DAPK1 P53355 human MRLC1 10398 P24844 MYL9 human S20 1863500 KRPQRAtsNVFAMFD X 3674; 3671; 3675; 95777 -DAPK1 DAPK1 P53355 human MCM3 4172 P25205 MCM3 human S160 2201400 KtIERRysDLttLVA MCM_OB X X -DAPK1 DAPK1 P53355 human PELI1 57162 Q96FA3 PELI1 human S39 1870773105 GDRGRRKsRFALFKR Pellino X X -DAPK1 DAPK1 P53355 human NMDAR2B 14812 Q01097 Grin2b mouse S1303 450171 NKLRRQHsyDtFVDL NMDAR2_C X 20274; 71335 -DAPK1 DAPK1 P53355 human RIGI 23586 O95786 RIGI human T667 63044900 ILTGRGktNQNtGMt Helicase_C X -DAPK1 DAPK1 P53355 human STX1A 116470 P32851 Stx1a rat S188 448071 IIMDSSIsKQALSEI Syntaxin X X -PRKD1 PRKD1 Q15139 human HDAC7 51564 Q8WUI4 HDAC7 human S486 452459 RPLsRAQssPAAPAs X 3424 -PRKD1 PRKD1 Q15139 human ATP7B 540 P35670 ATP7B human S1453 11267005 DDDGDKWsLLLNGRD X -PRKD1 PRKD1 Q15139 human COL4A3BP 10087 Q9Y5P4 CERT1 human S132 483985 ssLRRHGsMVsLVsG X X -PRKD1 PRKD1 Q15139 human CTNNB1 1499 P35222 CTNNB1 human T120 6406005 QFdAAHPtNVQRLAE X X -PRKD1 PRKD1 Q15139 human CACNA1C 100101555 P15381 CACB rabbit S1928 455278 ASLGRRAsFHLECLK CAC1F_C X -PRKD1 PRKD1 Q15139 human DLC1 10395 Q96QB1 DLC1 human S1244 17538201 NtLKRENsSPRVMQR X X -PRKD1 PRKD1 Q15139 human DRP1 10059 O00429 DNM1L human S637 483971 VPVARKLsAREQRDC X 4867; 6319 -PRKD1 PRKD1 Q15139 human CTNNB1 1499 P35222 CTNNB1 human T112 3075001 EGMQIPstQFdAAHP X X -PRKD1 PRKD1 Q15139 human AMPKA2 108079 Q8BRK8 Prkaa2 mouse S491 450432 stPQRSCsAAGLHRA AdenylateSensor X -PRKD1 PRKD1 Q15139 human TLR5 7100 O60602 TLR5 human S805 482842 yQLMKHQsIRGFVQK TIR X X -PRKD1 PRKD1 Q15139 human REM1 28954 O75628 REM1 human S18 4697668 TPLHRRAstPLPLsP X X -PRKD1 PRKD1 Q15139 human PIK3R1 18708 P26450 Pik3r1 mouse S652 20831301 TFLVRESsKQGCYAC SH2 X X -PRKD1 PRKD1 Q15139 human SPHK2 56848 Q9NRA0 SPHK2 human S421 486447 sPLHRsVsDLPLPLP X -PRKD1 PRKD1 Q15139 human ASK1 4217 Q99683 MAP3K5 human T838 448394 GINPCTEtFTGtLQY Pkinase X 3765 -PRKD1 PRKD1 Q15139 human PLEKHG5 269608 Q66T02 Plekhg5 mouse S92 27528601 SVLARNVsTRSCPPR X -PRKD1 PRKD1 Q15139 human ATP7B 540 P35670 ATP7B human S1121 11267007 AHSERPLsAPASHLN Hydrolase X -PRKD1 PRKD1 Q15139 human PAK4 10298 O96013 PAK4 human S99 2192540 MsVTRsNsLRRDsPP X X -PRKD1 PRKD1 Q15139 human PIK3R1 5295 P27986 PIK3R1 human S154 7445250 stLYRtQsSSNLAEL RhoGAP X X -PRKD1 PRKD1 Q15139 human Akt1 207 P31749 AKT1 human S473 447855 RPHFPQFsysAsGtA Pkinase_C X 9271; 3787; 4060; 4051; 5102; 4058; 2336; 2337; 4075; 4070; 5012; 4071; 92982; 5315; 9563; 9018; 12694; 52240; 11962; 15116; 88106; 26580; 68035; 31957; 23430; 20235 -PRKD1 PRKD1 Q15139 human PPP1R14A 94274 Q96A00 PPP1R14A human T38 449098 QkRHARVtVkYDRRE PP1_inhibitor X -PRKD1 PRKD1 Q15139 human OSBP P16258 OSBP rabbit S242 484804 TALQRSLsELESLKL X X -PRKD1 PRKD1 Q15139 human MYST2 11143 O95251 KAT7 human T97 3178404 kKYPLRQtRssGsEt X X -PRKD1 PRKD1 Q15139 human MYBPC3 4607 Q14896 MYBPC3 human S304 471081 SLLKKRDsFRtPRDs X -PRKD1 PRKD1 Q15139 human PIP5K1C 23396 O60331 PIP5K1C human S448 17550224 NTVFRKNsSLKSsPS X -PRKD1 PRKD1 Q15139 human CDH2 83501 Q9Z1Y3 Cdh2 rat S871 382737700 GSTAGsLssLNSSSS CADH_Y-type_LIR X -PRKD1 PRKD1 Q15139 human PRKD1 85421 Q9WTQ1 Prkd1 rat S748 448590 GEKsFRRsVVGTPAY Pkinase X -PRKD1 PRKD1 Q15139 human Syk 20963 P48025 Syk mouse S291 1983707 ISRIKsysFPKPGHK X -PRKD1 PRKD1 Q15139 human DRD1 24316 P18901 Drd1 rat S421 30310300 EKLSPALsVILDYDt X X -PRKD1 PRKD1 Q15139 human PIK4CB iso2 5298 Q9UBF8-2 PI4KB human S294 457621 SNLKRtAsNPKVENE X X -PRKD1 PRKD1 Q15139 human PTRH2 51651 Q9Y3E5 PTRH2 human S5 4206801 ___MPSKsLVMEYLA X -PRKD1 PRKD1 Q15139 human TNNI3 29248 P23693 Tnni3 rat S23 448423 PAPVRRRssANYRAY Troponin-I_N X 4004 -PRKD1 PRKD1 Q15139 human RTKN iso2 6242 Q9BST9-2 RTKN human S435 15423057 QALAKQGsLYHEMAI X X -PRKD1 PRKD1 Q15139 human Cortactin 2017 Q14247 CTTN human S298 5014901 EKLAkHEsQQDyskG HS1_rep X X -PRKD1 PRKD1 Q15139 human ATP7B 540 P35670 ATP7B human S481 11267006 ILAKsPQsTRAVAPQ X -PRKD1 PRKD1 Q15139 human CDH2 83501 Q9Z1Y3 Cdh2 rat S872 382737702 STAGsLssLNSSSSG CADH_Y-type_LIR X -PRKD1 PRKD1 Q15139 human AP-2 alpha 7020 P05549 TFAP2A human S258 5024712 GVLRRAKsKNGGRSL TF_AP-2 X -PRKD1 PRKD1 Q15139 human PRKD1 5587 Q15139 PRKD1 human S910 447632 KALGERVsIL_____ X X 2051; 75148 -PRKD1 PRKD1 Q15139 human OXTR 25342 P70536 Oxtr rat S261 1876282800 AALARVSsVKLISKA 7tm_1 X X -PRKD1 PRKD1 Q15139 human Rin1 9610 Q13671 RIN1 human S351 451364 RPLLRsMsAAFCSLL X X -PRKD1 PRKD1 Q15139 human AHCYL1 229709 Q80SW1 Ahcyl1 mouse S68 467244 RSLSRsIsQsstDsy X -PRKD1 PRKD1 Q15139 human ITGB4 iso2 3691 P16144-2 ITGB4 human T1736 1243302 EFVSRTLttSGTLST X X -PRKD1 PRKD1 Q15139 human PIK4CB 5298 Q9UBF8 PI4KB human S294 457621 SNLkRTAsNPKVENE X -PRKD1 PRKD1 Q15139 human AP2B1 163 P63010 AP2B1 human Y277 462925 LPkDsDyyNMLLkKL Adaptin_N X -PRKD1 PRKD1 Q15139 human OXTR 5021 P30559 OXTR human S261 1876282802 RVALARVsSVKLISK 7tm_1 X X -PRKD1 PRKD1 Q15139 human AP2B1 163 P63010 AP2B1 human S258 178605774 ANSAVVLsAVKVLMk Adaptin_N X -PRKD1 PRKD1 Q15139 human BAD 572 Q92934 BAD human S99 447862 PFrGrsRsAPPNLWA Bcl-2_BAD X 9295; 5286; 4366 -PRKD1 PRKD1 Q15139 human ATP7B 540 P35670 ATP7B human S478 11267008 APDILAKsPQsTRAV X -PRKD1 PRKD1 Q15139 human MFF 56947 Q9GZY8 MFF human S172 484865 GQLVRNDsLWHRsDs Miff X X -PRKD1 PRKD1 Q15139 human TNNI3 21954 P48787 Tnni3 mouse S24 448424 APVRRRssANyRAYA Troponin-I_N X -PRKD1 PRKD1 Q15139 human AP-2 alpha 7020 P05549 TFAP2A human S326 5024711 EFLNRQHsDPNEQVT TF_AP-2 X -PRKD1 PRKD1 Q15139 human HPK1 11184 Q92918 MAP4K1 human S171 455474 AtLARRLsFIGtPyW Pkinase X -PRKD1 PRKD1 Q15139 human TLR4 7099 O00206 TLR4 human S790 14932401 VELYRLLsRNTYLEW TIR X -PRKD1 PRKD1 Q15139 human HSP27 3315 P04792 HSPB1 human S82 448403 RALsRQLssGVsEIr X X 2406; 2401; 9709; 11892; 64293 -PRKD1 PRKD1 Q15139 human Telethonin 8557 O15273 TCAP human S157 448693 GALRRsLsRSMsQEA Telethonin X -PRKD1 PRKD1 Q15139 human HDAC7 51564 Q8WUI4 HDAC7 human S155 455620 FPLRKtVsEPNLkLR X 3443 -PRKD1 PRKD1 Q15139 human AMPKA1 105787 Q5EG47 Prkaa1 mouse S494 4717473 GtAtPQRsGsIsNYR AdenylateSensor X -PRKD1 PRKD1 Q15139 human SSH1 54434 Q8WYL5 SSH1 human S978 455275 sPLKRSHsLAKLGSL X X -PRKD1 PRKD1 Q15139 human BAD 572 Q92934 BAD human S75 447860 EIRsRHssyPAGtED Bcl-2_BAD X X 9291; 5284; 9296; 5193; 11865; 94223 -PRKD1 PRKD1 Q15139 human HDAC5 10014 Q9UQL6 HDAC5 human S498 447996 RPLSRtQsSPLPQsP X X 3424 -PRKD1 PRKD1 Q15139 human PAK5 57144 Q9P286 PAK5 human S99 29574070 ISVTRSNsLRKESPP X -PRKD1 PRKD1 Q15139 human CREB 1385 P16220 CREB1 human S119 448228 EILsRRPsyRkILND pKID X X 9187; 9196; 9198; 4095; 14228; 14001; 39561; 80120; 44864; 54960; 95995 -PRKD1 PRKD1 Q15139 human MFF 56947 Q9GZY8 MFF human S275 20651869 DNVRYGIsNIDTTIE Miff X X -PRKD1 PRKD1 Q15139 human PAK4 10298 O96013 PAK4 human S474 448023 kEVPRRksLVGtPyW Pkinase X 3241 -PRKD1 PRKD1 Q15139 human MARK2 2011 Q7KZI7 MARK2 human S400 5635600 HkVQRsVsANPKQRR X -PRKD1 PRKD1 Q15139 human CDH2 83501 Q9Z1Y3 Cdh2 rat S869 382737701 GSGSTAGsLssLNSS CADH_Y-type_LIR X -PRKD1 PRKD1 Q15139 human RABEP1 9135 Q15276 RABEP1 human S407 468548 DGLRRAQstDsLGts Rabaptin X -PRKD1 PRKD1 Q15139 human CREB iso1 1385 P16220-1 CREB1 human S98 1207200 KDLKRLFsGtQISTI X -PRKD1 PRKD1 Q15139 human PRKD1 85421 Q9WTQ1 Prkd1 rat S916 447632 KALSERVsIL_____ X -PRKD1 PRKD1 Q15139 human MYST2 11143 O95251 KAT7 human T331 18911980 LRLQGQItEGsNMIk X X -PRKD1 PRKD1 Q15139 human PRKD1 85421 Q9WTQ1 Prkd1 rat S744 448589 ARIIGEKsFRRsVVG Pkinase X -PRKD1 PRKD1 Q15139 human BAD 572 Q92934 BAD human S118 447863 GRELRRMsDEFVDsF Bcl-2_BAD X X 9297 -PRKD1 PRKD1 Q15139 human SPHK2 56848 Q9NRA0 SPHK2 human S419 486446 AHsPLHRsVsDLPLP X -PRKD1 PRKD1 Q15139 human PLEKHG5 269608 Q66T02 Plekhg5 mouse S806 27434500 PTILRKSsNSLDSEH X -PRKD1 PRKD1 Q15139 human PRKD1 5587 Q15139 PRKD1 human S738 448589 ARIIGEksFRRsVVG Pkinase X 2054 -PRKD1 PRKD1 Q15139 human HDAC7 51564 Q8WUI4 HDAC7 human S358 455621 WPLsRtRsEPLPPsA X -PRKD1 PRKD1 Q15139 human CACNA1C 775 Q13936 CACNA1C human S1981 455278 ASLGRRAsFHLECLK X -PRKD1 PRKD1 Q15139 human Cortactin 2017 Q14247 CTTN human S348 5014900 EAVTskTsNIRANFE X X -PRKD1 PRKD1 Q15139 human Jun 3725 P05412 JUN human S63 447686 kNsDLLtsPDVGLLk Jun X 5464; 9261; 2361; 97721; 91952 -PRKD1 PRKD1 Q15139 human TNNI3 21954 P48787 Tnni3 mouse S23 448423 PAPVRRRssANyRAY Troponin-I_N X -PRKD1 PRKD1 Q15139 human PIP4K2A 5305 P48426 PIP4K2A human T376 460716 KAAHAAktVKHGAGA PIP5K X X -PRKD1 PRKD1 Q15139 human Kv11.1 3757 Q12809 KCNH2 human S284 4696786 ASVRRAssADDIEAM X -PRKD1 PRKD1 Q15139 human KIDINS220 116478 Q9EQG6 Kidins220 rat S918 451418 RTITRQMsFDLTKLL KAP_NTPase X X -PRKD1 PRKD1 Q15139 human SPRY2 10253 O43597 SPRY2 human S112 465675 APLSRSIsTVssGsR X -PRKD1 PRKD1 Q15139 human arfaptin 1 27236 P53367 ARFIP1 human S132 3191827 LELVRKWsLNtyKCT Arfaptin X X -PRKD1 PRKD1 Q15139 human PTRH2 51651 Q9Y3E5 PTRH2 human S87 4206800 GkVAAQCsHAAVSAy PTH2 X X -PRKD1 PRKD1 Q15139 human TNNI3 29248 P23693 Tnni3 rat S24 448424 APVRRRssANYRAYA Troponin-I_N X 4004 -PRKD1 PRKD1 Q15139 human FAM83G 644815 A6ND36 FAM83G human S356 3147942 YALVKAKsVDEIAKI X X -PRKD1 PRKD1 Q15139 human SSH1 54434 Q8WYL5 SSH1 human S402 10989184 MGVSRsAstVIAyAM DSPc X -PRKD1 PRKD1 Q15139 human PAK4 10298 O96013 PAK4 human S181 2192531 SRDKRPLsGPDVGtP X X -PRKD1 PRKD1 Q15139 human MBP iso5 4155 P02686-5 MBP human S162 456582 FKLGGRDsRSGSPMA Myelin_MBP X -PRKD1 PRKD1 Q15139 human Cofilin-1 1072 P23528 CFL1 human S3 448444 _____MAsGVAVsDG X 3313; 3311 -PRKD1 PRKD1 Q15139 human HDAC5 10014 Q9UQL6 HDAC5 human S259 447995 FPLRkTAsEPNLKVR X 3443 -PRKD1 PRKD1 Q15139 human NLRP3 216799 Q8R4B8 Nlrp3 mouse S291 57761902 CKILRKPsRILFLMD NACHT X -PRKD1 PRKD1 Q15139 human Rin1 9610 Q13671 RIN1 human S292 4949757 QLLRREssVGyRVPA X X -PRKD1 PRKD1 Q15139 human SSH1 54434 Q8WYL5 SSH1 human S937 455274 SNLtRssssDsIHsV X X -PRKD1 PRKD1 Q15139 human MFF 56947 Q9GZY8 MFF human S155 470753 GRLkRERsMsENAVR Miff X X -PRKD1 PRKD1 Q15139 human PRKD1 5587 Q15139 PRKD1 human S742 448590 GEksFRRsVVGtPAy Pkinase X -PRKD1 PRKD1 Q15139 human Snail1 6615 O95863 SNAI1 human S11 11493500 SFLVRKPsDPNRKPN X X -PRKD1 PRKD1 Q15139 human OSBP 5007 P22059 OSBP human S240 484804 tALQRsLsELESLkL X -PRKD1 PRKD1 Q15139 human VASP 7408 P50552 VASP human S157 448379 EHIERRVsNAGGPPA X X 3111; 84519 -PRKD1 PRKD1 Q15139 human HSP20 126393 O14558 HSPB6 human S16 450706 PSWLRRAsAPLPGLS Crystallin X X 36519 -PRKD1 PRKD1 Q15139 human VASP 7408 P50552 VASP human S322 469024 TtLPRMkssssVttS X X -PRKD1 PRKD1 Q15139 human AP-2 alpha 21418 P34056 Tfap2a mouse S258 5024712 GVLRRAKsKNGGrSL TF_AP-2 X -PRKD1 PRKD1 Q15139 human Akt1 207 P31749 AKT1 human T308 447856 kDGAtMKtFCGtPEy Pkinase X 5106; 2965; 9275; 4056; 5056; 13842; 13038; 43506; 48646; 86758; 80722; 77440; 80556 -PRKD1 PRKD1 Q15139 human Telethonin 8557 O15273 TCAP human S161 3893741 RsLsRSMsQEAQRG_ Telethonin X -MAP3K7 TAK1 O43318 human RCAN1 266766 Q6IN33 Rcan1 rat S94 6374005 QTLHIGssHLAPPNP Calcipressin X X -MAP3K7 TAK1 O43318 human TUBA1B 10376 P68363 TUBA1B human T334 3653841 DVNAAIAtIktkrsI Tubulin_C X -MAP3K7 TAK1 O43318 human RCAN1 266766 Q6IN33 Rcan1 rat S136 6374004 YDLLYAIsKLGPGEK Calcipressin X X -MAP3K7 TAK1 O43318 human PTPN3 5774 P26045 PTPN3 human S359 451191 PAMRRsLsVEHLETK X -MAP3K7 TAK1 O43318 human EIF4B 1975 P23588 EIF4B human S230 4333942 kyRDRyDsDRyRDGy X -MAP3K7 TAK1 O43318 human hnRNP A2/B1 3181 P22626 HNRNPA2B1 human T176 476090 IVLQkyHtINGHNAE RRM_1 X -MAP3K7 TAK1 O43318 human FLNA 2316 P21333 FLNA human T1286 10787026 sVDARALtQtGGPHV Filamin X -MAP3K7 TAK1 O43318 human RBMX 27316 P38159 RBMX human T216 3887573 PRDDGystkDsyssR RBM1CTR X -MAP3K7 TAK1 O43318 human TAK1 6885 O43318 MAP3K7 human T184 454876 GtACDIQtHMtNNKG PK_Tyr_Ser-Thr X X 4531; 4508; 4537 -MAP3K7 TAK1 O43318 human TAB1 10454 Q15750 TAB1 human S452 22869801 STNTHTQssSSssDG X X -MAP3K7 TAK1 O43318 human TAK1 6885 O43318 MAP3K7 human S192 448289 HMtNNKGsAAWMAPE PK_Tyr_Ser-Thr X -MAP3K7 TAK1 O43318 human plakophilin 2 5318 Q99959 PKP2 human S82 468460 GNLHRtssVPEyVyN X X -MAP3K7 TAK1 O43318 human TAB1 10454 Q15750 TAB1 human S456 22869802 HTQssSSssDGGLFR X X -MAP3K7 TAK1 O43318 human HIPK2 28996 Q9H2X6 HIPK2 human Y361 449571 SkAVCstyLQsRYyR Pkinase X -MAP3K7 TAK1 O43318 human GRP94 7184 P14625 HSP90B1 human S674 31855603 yQtGkDIstNyyAsQ HSP90 X -MAP3K7 TAK1 O43318 human GRP94 7184 P14625 HSP90B1 human T669 38485693 MkAQAyQtGkDIstN HSP90 X -MAP3K7 TAK1 O43318 human GRP94 7184 P14625 HSP90B1 human T675 57812706 QtGkDIstNyyAsQk HSP90 X -MAP3K7 TAK1 O43318 human RAB1A 5861 P62820 RAB1A human T75 1247157 AGQERFRtItSSyyR Ras X X -MAP3K7 TAK1 O43318 human RAB8A 4218 P61006 RAB8A human T72 4709152 AGQERFRtITTAyyR Ras X -MAP3K7 TAK1 O43318 human CDC25C 995 P30307 CDC25C human S216 448418 sGLyRsPsMPENLNR M-inducer_phosp X X 9528; 4901; 30790 -MAP3K7 TAK1 O43318 human RIPK1 19766 Q60855 Ripk1 mouse S321 468644 PVLQRMFsLQHDCVP X X 83613; 38662 -MAP3K7 TAK1 O43318 human POLD2 5425 P49005 POLD2 human T33 57812708 RVPVATytNSSQPFR X -MAP3K7 TAK1 O43318 human HDAC7 51564 Q8WUI4 HDAC7 human S155 455620 FPLRKtVsEPNLkLR X X 3443 -MAP3K7 TAK1 O43318 human HDAC4 9759 P56524 HDAC4 human S246 448488 FPLRkTAsEPNLKLR X 3443 -MAP3K7 TAK1 O43318 human TUBB 203068 P07437 TUBB human T166 31889875 yPDrIMNtFsVVPsP Tubulin X -MAP3K7 TAK1 O43318 human KSR 8844 Q8IVT5 KSR1 human S406 449297 TRLRRtEsVPsDINN X X 4951 -MAP3K7 TAK1 O43318 human TAB1 10454 Q15750 TAB1 human S457 22869800 TQssSSssDGGLFRS X X -MAP3K7 TAK1 O43318 human TNFAIP8L2 79626 Q6P589 TNFAIP8L2 human S3 56660955 _____MEsFSSKSLA X -MAP3K7 TAK1 O43318 human TAK1 6885 O43318 MAP3K7 human T187 454704 CDIQtHMtNNKGsAA PK_Tyr_Ser-Thr X X 4536; 4531; 4508 -MAP3K7 TAK1 O43318 human TAB1 10454 Q15750 TAB1 human S453 22869803 TNTHTQssSSssDGG X X -MAP3K7 TAK1 O43318 human GAPVD1 26130 Q14C86 GAPVD1 human T1013 10989095 LGPDRFstLtDDPsP X -MAP3K7 TAK1 O43318 human AMPKA2 5563 P54646 PRKAA2 human T172 448026 sDGEFLRtsCGsPNy Pkinase X X 2535; 2531; 5256; 50081; 74281 -MAP3K7 TAK1 O43318 human GAPVD1 26130 Q14C86 GAPVD1 human S1012 57812705 DLGPDRFstLtDDPs X -MAP3K7 TAK1 O43318 human E2F1 1869 Q01094 E2F1 human S337 447869 IVsPPPSsPPSSLTT X -MAP3K7 TAK1 O43318 human IKKB 3551 O14920 IKBKB human S177 447492 AkELDQGsLCtsFVG Pkinase X 2078; 2697; 2694; 14938; 92255; 36516; 36214 -MAP3K7 TAK1 O43318 human ATAT1 79969 Q5SQI0 ATAT1 human S237 1095631200 GDIkPYSsSDREFLK X X -MAP3K7 TAK1 O43318 human HDAC5 10014 Q9UQL6 HDAC5 human S259 447995 FPLRkTAsEPNLKVR X 3443 -MAP3K7 TAK1 O43318 human IKKB 3551 O14920 IKBKB human S181 447489 DQGsLCtsFVGTLQy Pkinase X 2697; 2694; 14938; 92255; 36516; 36214 -MAP3K7 TAK1 O43318 human TAK1 6885 O43318 MAP3K7 human T178 3303400 LKICDFGtACDIQtH PK_Tyr_Ser-Thr X -MAP3K7 TAK1 O43318 human EEF1A1 1915 P68104 EEF1A1 human T261 23101713 ykIGGIGtVPVGrVE GTP_EFTU_D2 X -MAP3K7 TAK1 O43318 human LDH-A 3939 P00338 LDHA human T3 57812707 _____MAtLkDQLIy X -Rps6kb2 P70S6KB Q9Z1M4 mouse S6 20104 P62754 Rps6 mouse S235 448092 IAKRRRLssLRAsts X 5006; 4856; 4857; 4858; 4851; 4803; 2211; 3945; 3985; 5316; 4854; 8520; 48319; 40643; 9865; 38573; 14733; 27036; 34411; 62016; 62788; 81736; 97935; 99457; 15448 -Rps6kb2 P70S6KB Q9Z1M4 mouse S6 20104 P62754 Rps6 mouse S236 448093 AKRRRLssLRAstsK X 5006; 4856; 4857; 4858; 4851; 4803; 2211; 3945; 3985; 5316; 4854; 8520; 48319; 40643; 9865; 38573; 14733; 27036; 34411; 62016; 62788; 81736; 97935; 99457; 15448 -Cdk6 CDK6 Q64261 mouse C/EBP-alpha 12606 P53566 Cebpa mouse S193 1868113505 PPPHPHAsPAHLAAP X X -Cdk6 CDK6 Q64261 mouse Rb 19645 P13405 Rb1 mouse T819 447984 LPtPtKMtPRSRILV Rb_C X -Cdk6 CDK6 Q64261 mouse Rb 19645 P13405 Rb1 mouse S804 448717 IyIsPLksPyKIsEG Rb_C X 9308; 8974; 4277; 40283; 8957; 8516; 11917; 41359; 75864 -Cdk6 CDK6 Q64261 mouse Rb 19645 P13405 Rb1 mouse S243 447975 AAIPINGsPRtPRRG X -Cdk6 CDK6 Q64261 mouse Rb 19645 P13405 Rb1 mouse T246 449821 PINGsPRtPRRGQNR X -Cdk6 CDK6 Q64261 mouse Rb 19645 P13405 Rb1 mouse S800 447980 PGGNIyIsPLksPyK Rb_C X 9308; 8974; 4277; 40283; 8957; 8516; 11917; 41359; 75864; 72443 -Fyn Fyn Q62844 rat CDK5 140908 Q03114 Cdk5 rat Y15 448022 EKIGEGTyGTVFKAK Pkinase X 94254; 19051 -Fyn Fyn Q62844 rat CRMP-1 25415 Q62950 Crmp1 rat Y504 454682 GMyDGPVyEVPAtPk X -Fyn Fyn Q62844 rat NPHS1 64563 Q9R044 Nphs1 rat Y1153 1317600 AEVDPNyySMRDFSP X -Fyn Fyn Q62844 rat ADD2 24171 Q05764 Add2 rat Y489 449419 PNQFVPLyTDPQEVL X -Fyn Fyn Q62844 rat IGF2BP1 303477 Q8CGX0 Igf2bp1 rat Y396 458348 SVTGAAPyGSFMQAP X -KIT Kit P10721 human Kit 3815 P10721 KIT human Y553 13876401 KyLQKPMyEVQWKVV X -KIT Kit P10721 human Kit 3815 P10721 KIT human Y703 448016 DHAEAALyKNLLHSK PK_Tyr_Ser-Thr X 3073 -KIT Kit P10721 human SLAP 6503 Q13239 SLA human Y273 467049 sFFSSPPyFED____ X -KIT Kit P10721 human Kit 3815 P10721 KIT human Y568 448014 EEINGNNyVyIDPTQ X 48347 -KIT Kit P10721 human Kit 3815 P10721 KIT human Y547 13876400 VMILTYKyLQKPMyE X -KIT Kit P10721 human Kit 3815 P10721 KIT human Y936 448019 SEsTNHIysNLANCs X -KIT Kit P10721 human PHB 5245 P35232 PHB1 human Y259 6374000 SRSRNItyLPAGQsV X X -KIT Kit P10721 human Kit 3815 P10721 KIT human Y721 448017 CSDStNEyMDMKPGV PK_Tyr_Ser-Thr X 3391 -KIT Kit P10721 human Kit 16590 P05532 Kit mouse Y706 448016 EQAEAALyKNLLHST PK_Tyr_Ser-Thr X -KIT Kit P10721 human Kit 3815 P10721 KIT human Y570 448015 INGNNyVyIDPTQLP X 48347 -KIT Kit P10721 human LAB 7462 Q9GZY6 LAT2 human Y110 454708 RHGsEEAyIDPIAME LAT2 X -KIT Kit P10721 human SLAP 6503 Q13239 SLA human Y120 15570321 SETKkGFySLSVRHR SH2 X -KIT Kit P10721 human LAB 7462 Q9GZY6 LAT2 human Y118 454709 IDPIAMEyyNWGRFS LAT2 X -KIT Kit P10721 human SLAP 6503 Q13239 SLA human Y258 1018109 KksIsLMyGGskRkS X -KIT Kit P10721 human Kit 3815 P10721 KIT human Y823 448018 DIKNDsNyVVKGNAR PK_Tyr_Ser-Thr X 77522 -EIF2AK2 PKR P19525 human eIF2-alpha 100339093 P83268 EIF2S1 rabbit S51 447635 RILLsELsR______ S1 X 3398; 5199; 95797 -EIF2AK2 PKR P19525 human NFAT90 16201 Q9Z1X4 Ilf3 mouse T188 17734001 EKVLAGEtLsVNDPP DZF X -EIF2AK2 PKR P19525 human PKR 5610 P19525 EIF2AK2 human S242 448085 NQRKAKRsLAPRFDL X X -EIF2AK2 PKR P19525 human PKR 5610 P19525 EIF2AK2 human S83 3181640 NkEKkAVsPLLLttt X -EIF2AK2 PKR P19525 human PKR 5610 P19525 EIF2AK2 human T451 448089 kRtRSKGtLRyMsPE Pkinase X X -EIF2AK2 PKR P19525 human CDK1 983 P06493 CDK1 human Y4 473276 ____MEDytkIEkIG Pkinase X X -EIF2AK2 PKR P19525 human eIF2-alpha 54318 P68101 Eif2s1 rat S52 447635 MILLSELsRRRIRSI S1 X 3597; 9721; 3398; 5199; 53085; 95797 -EIF2AK2 PKR P19525 human PKR 5610 P19525 EIF2AK2 human Y293 458273 HRIDGKTyVIKRVkY Pkinase X X -EIF2AK2 PKR P19525 human Tau iso8 4137 P10636-8 MAPT human S262 447930 NVKskIGstENLkHQ Tubulin-binding X -EIF2AK2 PKR P19525 human JMJD2C 23081 Q9H3R0 KDM4C human S918 1869778705 MFDDGsFsRDTFPED X -EIF2AK2 PKR P19525 human p53 7157 P04637 TP53 human S392 447535 FktEGPDsD______ X X 9281 -EIF2AK2 PKR P19525 human PKR 5610 P19525 EIF2AK2 human T446 448088 LkNDGkRtRSKGtLR Pkinase X X -EIF2AK2 PKR P19525 human PKR 5610 P19525 EIF2AK2 human S6 23132463 __MAGDLsAGFFMEE X -EIF2AK2 PKR P19525 human PKR 5610 P19525 EIF2AK2 human Y162 458272 QLAAkLAyLQILSEE dsrm X X -EIF2AK2 PKR P19525 human eIF2-alpha 1965 P05198 EIF2S1 human S49 450210 IEGMILLsELsRRRI S1 X -EIF2AK2 PKR P19525 human IRS1 16367 P35569 Irs1 mouse S307 447558 tEsITAtsPAsMVGG X 2381 -EIF2AK2 PKR P19525 human PKR 5610 P19525 EIF2AK2 human T255 448086 DLPDMkEtKytVDKR X X -EIF2AK2 PKR P19525 human Tau iso8 4137 P10636-8 MAPT human S356 449104 rVQskIGsLDNItHV Tubulin-binding X -EIF2AK2 PKR P19525 human PKR 5610 P19525 EIF2AK2 human T89 3753307 VsPLLLtttNssEGL X -EIF2AK2 PKR P19525 human eIF2-alpha 100339093 P83268 EIF2S1 rabbit S48 450210 IEGRILLsELsR___ S1 X -EIF2AK2 PKR P19525 human PKR 5610 P19525 EIF2AK2 human T88 3753308 AVsPLLLtttNssEG X -EIF2AK2 PKR P19525 human PPP2R5A 5525 Q15172 PPP2R5A human S28 459127 VDGFTRKsVRKAQRQ X X -EIF2AK2 PKR P19525 human TIF1B 10155 Q13263 TRIM28 human S473 452391 sGVkRsRsGEGEVsG X -EIF2AK2 PKR P19525 human PKR 5610 P19525 EIF2AK2 human T90 3181643 sPLLLtttNssEGLs X -EIF2AK2 PKR P19525 human eIF2-alpha 1965 P05198 EIF2S1 human S52 447635 MILLsELsRRRIRsI S1 X X 3597; 9721; 3398; 5199; 53085; 95797 -EIF2AK2 PKR P19525 human NFAT90 16201 Q9Z1X4 Ilf3 mouse T315 17734000 RQQREDItQSAQHAL DZF X -EIF2AK2 PKR P19525 human PKR 5610 P19525 EIF2AK2 human Y101 458271 EGLsMGNyIGLINRI dsrm X X -EIF2AK2 PKR P19525 human PKR 5610 P19525 EIF2AK2 human T258 448087 DMkEtKytVDKRFGM X X -Igf1r IGF1R Q60751 mouse IGF1R 16001 Q60751 Igf1r mouse Y974 449827 RLGNGVLyASVNPEy X X -Igf1r IGF1R Q60751 mouse IGF1R 16001 Q60751 Igf1r mouse Y981 448390 yASVNPEyFSAADVY X X 4568 -Igf1r IGF1R Q60751 mouse IGF1R 16001 Q60751 Igf1r mouse Y1167 448387 RDIyEtDyyRKGGkG PK_Tyr_Ser-Thr X 3024; 3918; 2969 -Igf1r IGF1R Q60751 mouse IGF1R 16001 Q60751 Igf1r mouse Y1163 448386 FGMTRDIyEtDyyRK PK_Tyr_Ser-Thr X X 3021; 80732 -Igf1r IGF1R Q60751 mouse IGF1R 16001 Q60751 Igf1r mouse Y1352 448389 sFDERQPyAHMNGGR X X 28897 -Igf1r IGF1R Q60751 mouse CRK 12928 Q64010 Crk mouse Y221 447951 GGPEPGPyAQPsVNt X 3491 -Igf1r IGF1R Q60751 mouse IGF1R 16001 Q60751 Igf1r mouse Y1168 448388 DIyEtDyyRKGGkGL PK_Tyr_Ser-Thr X X 3024; 2969 -Trpm7 ChaK1 Q923J1 mouse ChaK1 58800 Q923J1 Trpm7 mouse S1567 455464 NLMRLsQsIPFVPVP X X -Trpm7 ChaK1 Q923J1 mouse ChaK1 58800 Q923J1 Trpm7 mouse S1511 455463 EDsPEVdsKAALLPD X X -Kdr VEGFR2 O08775 rat VEGFR2 25589 O08775 Kdr rat Y1171 447901 AQQDGKDyIVLPMSE X 2478; 3770 -Camkk2 CAMKK2 O88831 rat AMPKA1 65248 P54645 Prkaa1 rat T183 448786 SDGEFLRtsCGSPNY Pkinase X 2535; 2531; 4188; 5256; 50081; 74281 -Camkk2 CAMKK2 O88831 rat CAMK4 25050 P13234 Camk4 rat S11 2827404 VTVPsCPssPCsSVT X -Camkk2 CAMKK2 O88831 rat CAMK4 25050 P13234 Camk4 rat S8 2827402 MLKVTVPsCPssPCs X -Camkk2 CAMKK2 O88831 rat CAMK4 25050 P13234 Camk4 rat S353 2827401 QESNKASsEAQPAQD X -Camkk2 CAMKK2 O88831 rat CAMK4 25050 P13234 Camk4 rat S15 2827405 sCPssPCsSVTSSTE X -EPHA2 EphA2 P29317 human EphA2 1969 P29317 EPHA2 human Y921 457515 ESIKMQQytEHFMAA SAM_1 X -EPHA2 EphA2 P29317 human EphA2 1969 P29317 EPHA2 human Y575 454954 RQsPEDVyFsksEQL EphA2_TM X -EPHA2 EphA2 P29317 human EphA2 1969 P29317 EPHA2 human Y694 461993 PMMIItEyMENGALD PK_Tyr_Ser-Thr X -EPHA2 EphA2 P29317 human EphA2 1969 P29317 EPHA2 human Y628 461992 AGEFGEVykGMLKTS PK_Tyr_Ser-Thr X -EPHA2 EphA2 P29317 human GLO1 2739 Q04760 GLO1 human Y136 463450 GIAVPDVysACkRFE Glyoxalase X -EPHA2 EphA2 P29317 human EphA2 1969 P29317 EPHA2 human Y772 450861 EDDPEAtyttsGGkI PK_Tyr_Ser-Thr X X 8244; 8862 -EPHA2 EphA2 P29317 human EphA2 1969 P29317 EPHA2 human Y960 461994 GHQKRIAysLLGLKD SAM_1 X -EPHA2 EphA2 P29317 human EphA2 1969 P29317 EPHA2 human Y588 450859 QLkPLktyVDPHtyE EphA2_TM X X 12677 -EPHA2 EphA2 P29317 human Claudin-4 1364 O14493 CLDN4 human Y208 451666 RsAAAsNyV______ X -EPHA2 EphA2 P29317 human EphA2 1969 P29317 EPHA2 human Y594 450860 tyVDPHtyEDPNQAV EphA2_TM X X 3970 -EPHA2 EphA2 P29317 human EphA2 1969 P29317 EPHA2 human Y735 473293 kYLANMNyVHRDLAA PK_Tyr_Ser-Thr X X -EPHA2 EphA2 P29317 human Yes 7525 P07947 YES1 human Y426 447619 RLIEDNEytARQGAk PK_Tyr_Ser-Thr X X 2101; 6943; 59548; 70926; 78740; 94361; 17320 -PTK2 FAK Q00944 chicken GIT2 374035 Q9Y621 GIT2 chicken Y286 456753 EELAMYVyDEVDRRE GIT_SHD X -PTK2 FAK Q00944 chicken GIT2 374035 Q9Y621 GIT2 chicken Y392 456754 QDNDQPDyDSVASDE X 11873 -PTK2 FAK Q00944 chicken FAK 396416 Q00944 PTK2 chicken Y397 447887 sVsETDDyAEIIDEE X X 3283; 8556 -PTK2 FAK Q00944 chicken GIT2 374035 Q9Y621 GIT2 chicken Y592 450866 SSVPESDyDNTTASL X -Met Met P97523 rat Met 4233 P08581 MET human Y1234 448470 RDMyDkEyysVHNkt PK_Tyr_Ser-Thr X 4091; 3129; 3126; 3077; 12468; 4033; 98954 -Met Met P97523 rat Met 4233 P08581 MET human Y1235 448471 DMyDkEyysVHNktG PK_Tyr_Ser-Thr X 4091; 3129; 3126; 3077; 12468; 4033; 98954 -STK11 LKB1 Q15831 human PTEN 5728 P60484 PTEN human S380 448313 EPDHyRYsDttDsDP X X 9551; 9554; 9549; 7960 -STK11 LKB1 Q15831 human QSK 70661 Q6P4S6 Sik3 mouse T221 456036 TPGQLLKtWCGsPPY Pkinase X -STK11 LKB1 Q15831 human SMAD4 4089 Q13485 SMAD4 human T77 17478300 kCVTIQRtLDGRLQV MH1 X -STK11 LKB1 Q15831 human NuaK2 81788 Q9H093 NUAK2 human T208 456033 HQGKFLQtFCGSPLY Pkinase X X -STK11 LKB1 Q15831 human SIRT1 23411 Q96EB6 SIRT1 human S615 7998455 GEkNERtsVAGtVRk X X -STK11 LKB1 Q15831 human TORC1 23373 Q6UUV9 CRTC1 human S151 481986 TSWRRtNsDsALHQs TORC_M X 3359 -STK11 LKB1 Q15831 human AMPKA1 65248 P54645 Prkaa1 rat T183 448786 SDGEFLRtsCGSPNY Pkinase X 2535; 2531; 4188; 5256; 50081; 74281 -STK11 LKB1 Q15831 human NuaK1 9891 O60285 NUAK1 human T211 456032 QKDKFLQtFCGSPLY Pkinase X X -STK11 LKB1 Q15831 human AMPKA1 105787 Q5EG47 Prkaa1 mouse T183 448786 sDGEFLRtsCGsPNY Pkinase X X 2535; 2531; 4188; 5256; 50081; 74281 -STK11 LKB1 Q15831 human MELK 9833 Q14680 MELK human T167 456039 NkDyHLQtCCGsLAY Pkinase X -STK11 LKB1 Q15831 human AMPKA1 5562 Q13131 PRKAA1 human T183 448786 sDGEFLRtsCGsPNy Pkinase X X 2535; 2531; 4188; 5256; 50081; 74281 -STK11 LKB1 Q15831 human MARK4 57787 Q96L34 MARK4 human T214 456038 TLGSKLDtFCGsPPY Pkinase X X -STK11 LKB1 Q15831 human BRSK2 9024 Q8IWQ3 BRSK2 human T174 456031 VGDSLLEtSCGSPHY Pkinase X -STK11 LKB1 Q15831 human SIRT1 23411 Q96EB6 SIRT1 human S732 1874020214 EAINEAIsVkQEVTD X X -STK11 LKB1 Q15831 human p53 7157 P04637 TP53 human S392 447535 FktEGPDsD______ X X 9281 -STK11 LKB1 Q15831 human YAP1 iso2 10413 P46937-2 YAP1 human S127 448847 PQHVRAHssPASLQL X 57706 -STK11 LKB1 Q15831 human QIK 23235 Q9H0K1 SIK2 human T175 456035 kSGELLAtWCGSPPY Pkinase X X -STK11 LKB1 Q15831 human MARK2 2011 Q7KZI7 MARK2 human T208 449999 tFGNKLDtFCGsPPY Pkinase X X 4836 -STK11 LKB1 Q15831 human LKB1 6794 Q15831 STK11 human T363 448151 IEDDIIYtQDFTVPG X -STK11 LKB1 Q15831 human AMPKA2 108079 Q8BRK8 Prkaa2 mouse T172 448026 sDGEFLRtsCGsPNY Pkinase X 2535; 2531; 5256; 50081; 74281 -STK11 LKB1 Q15831 human LKB1 6794 Q15831 STK11 human T185 11454701 kPGNLLLtTGGtLKI Pkinase X -STK11 LKB1 Q15831 human PRMT5 10419 O14744 PRMT5 human T132 1267669103 PLNQEDNtNLARVLt PRMT5_TIM X -STK11 LKB1 Q15831 human LKB1 6794 Q15831 STK11 human T189 448149 LLLtTGGtLKISDLG Pkinase X 3054 -STK11 LKB1 Q15831 human MARK3 4140 P27448 MARK3 human T211 450314 TVGGKLDtFCGsPPY Pkinase X X 4836 -STK11 LKB1 Q15831 human SIK 59329 Q9R1U5 Sik1 rat T182 456034 KPGEPLStWCGsPPY Pkinase X -STK11 LKB1 Q15831 human MBP 100344447 P25274 MBP rabbit T65 451757 KDHAARTtHYGSLPQ Myelin_MBP X -STK11 LKB1 Q15831 human STRAD 92335 Q7RTN6 STRADA human T329 11454703 GLSDSLTtSTPRPSN Pkinase X -STK11 LKB1 Q15831 human MARK3 4140 P27448 MARK3 human S215 450315 KLDtFCGsPPYAAPE Pkinase X -STK11 LKB1 Q15831 human BRSK1 iso2 84446 Q8TDC3-2 BRSK1 human T205 456027 VGDSLLEtSCGsPHY Pkinase X -STK11 LKB1 Q15831 human LKB1 6794 Q15831 STK11 human S428 448147 SSkIRRLsACkQQ__ X 3482 -STK11 LKB1 Q15831 human SIK 150094 P57059 SIK1 human T182 456034 kSGEPLStWCGSPPY Pkinase X X -STK11 LKB1 Q15831 human PRMT5 10419 O14744 PRMT5 human T144 1267669104 VLtNHIHtGHHSSMF PRMT5_TIM X X -STK11 LKB1 Q15831 human PAK1 5058 Q13153 PAK1 human T109 14150103 QWARLLQtsNITKsE PBD X -STK11 LKB1 Q15831 human LKB1 6794 Q15831 STK11 human T402 11454702 TEAAQLstKsRAEGR X -STK11 LKB1 Q15831 human hnRNP I iso1 5725 P26599-1 PTBP1 human T138 18010516 sNHkELktDssPNQA RRM_5 X X -STK11 LKB1 Q15831 human BRSK1 84446 Q8TDC3 BRSK1 human T189 456027 VGDSLLEtSCGSPHY Pkinase X -STK11 LKB1 Q15831 human p21Cip1 1026 P38936 CDKN1A human T80 36528801 LPkLYLPtGPRRGRD X X -STK11 LKB1 Q15831 human QSK 23387 Q9Y2K2 SIK3 human T221 456036 TPGQLLKtWCGSPPY Pkinase X X -STK11 LKB1 Q15831 human LKB1 6794 Q15831 STK11 human T336 448150 KDRWRsMtVVPYLED X -STK11 LKB1 Q15831 human SIRT1 23411 Q96EB6 SIRT1 human S669 1874020212 EDDVLSSsSCGSNSD X X -STK11 LKB1 Q15831 human PRMT5 10419 O14744 PRMT5 human T139 1267669102 tNLARVLtNHIHtGH PRMT5_TIM X X -STK11 LKB1 Q15831 human MARK1 4139 Q9P0L2 MARK1 human T215 456037 TVGNKLDtFCGsPPY Pkinase X X 4836 -STK11 LKB1 Q15831 human AMPKA2 5563 P54646 PRKAA2 human T172 448026 sDGEFLRtsCGsPNy Pkinase X X 2535; 2531; 5256; 50081; 74281 -STK11 LKB1 Q15831 human STRAD 92335 Q7RTN6 STRADA human T419 11454704 SGIFGLVtNLEELEV X -STK11 LKB1 Q15831 human p53 7157 P04637 TP53 human S15 447490 PsVEPPLsQEtFsDL P53_TAD X X 4030; 9235; 9284; 9286; 8695; 8514; 82530; 56979 -STK11 LKB1 Q15831 human PTEN 5728 P60484 PTEN human T383 448315 HyRYsDttDsDPENE X X 9554; 9549; 7960 -STK11 LKB1 Q15831 human SNRK 54861 Q9NRH2 SNRK human T173 456502 QPGKKLttsCGSLAY Pkinase X -STK11 LKB1 Q15831 human PTEN 5728 P60484 PTEN human T382 448314 DHyRYsDttDsDPEN X X 9554; 9549; 7960 -aurka AurA Q91820 frog KIF2C 380006 Q91636 kif2c frog S196 2132102 NNQGRRKsNIVKEME X -aurka AurA Q91820 frog KIF2C 380006 Q91636 kif2c frog S719 3545002 LQVEEQAsKQISKKK X -Sik2 QIK Q8CFH6 mouse CDK5R1 12569 P61809 Cdk5r1 mouse S91 12607404 ENLKKSLsCANLSTF X -Sik2 QIK Q8CFH6 mouse IRS1 3667 P35568 IRS1 human S794 447557 QHLRLSTsSGRLLyA X X 2389 -Sik2 QIK Q8CFH6 mouse IRS1 25467 P35570 Irs1 rat S789 447557 QHLRLSSsSGRLRYT X X 2389 -Sik2 QIK Q8CFH6 mouse TORC2 74343 Q3U182 Crtc2 mouse S171 454622 sALNRtSsDsALHTs TORC_M X -CAMK2D CAMK2D iso8 Q13557-8 human TPD52 7163 P55327 TPD52 human S176 465974 kNsPtFksFEEkVEN TPD52 X X -MARK1 MARK1 Q9P0L2 human Tau iso8 4137 P10636-8 MAPT human T231 449079 KKVAVVRtPPKsPss X 20473; 71429 -MARK1 MARK1 Q9P0L2 human Tau iso8 4137 P10636-8 MAPT human S320 450139 VDLskVtskCGsLGN Tubulin-binding X -MARK1 MARK1 Q9P0L2 human Tau iso8 4137 P10636-8 MAPT human S396 449081 GAEIVyKsPVVsGDt X 9632 -MARK1 MARK1 Q9P0L2 human Tau iso8 4137 P10636-8 MAPT human S262 447930 NVKskIGstENLkHQ Tubulin-binding X X -MARK1 MARK1 Q9P0L2 human Tau iso8 4137 P10636-8 MAPT human S324 449328 kVtskCGsLGNIHHk Tubulin-binding X -MARK1 MARK1 Q9P0L2 human Tau iso8 4137 P10636-8 MAPT human S293 449327 NVQskCGsKDNIkHV Tubulin-binding X -MARK1 MARK1 Q9P0L2 human TNK1 8711 Q13470 TNK1 human S502 483166 RMKGIsRsLEsVLsL X -MARK1 MARK1 Q9P0L2 human DIXDC1 iso2 85458 Q155Q3-2 DIXDC1 human S381 23099075 SKLPHSQsSPTVSST X -MARK1 MARK1 Q9P0L2 human Tau iso8 4137 P10636-8 MAPT human S356 449104 rVQskIGsLDNItHV Tubulin-binding X -MARK1 MARK1 Q9P0L2 human FEZ1 9638 Q99689 FEZ1 human S58 454522 SEIISFKsMEDLVNE FEZ X X -MARK1 MARK1 Q9P0L2 human DIXDC1 85458 Q155Q3 DIXDC1 human S592 23099075 SKLPHsQssPTVSST X -MARK1 MARK1 Q9P0L2 human Doublecortin 13193 O88809 Dcx mouse S47 451112 TRTLQALsNEKKAKK X -MARK1 MARK1 Q9P0L2 human Tau iso8 4137 P10636-8 MAPT human S422 449083 GsIDMVDsPQLAtLA X -MARK1 MARK1 Q9P0L2 human Tau iso8 4137 P10636-8 MAPT human S305 487457 kHVPGGGsVQIVykP Tubulin-binding X -GRK7 GRK7 Q8WTQ7 human occludin 100506658 Q16625 OCLN human S471 6094301 LDDyREEsEEyMAAA Occludin_ELL X -Rps6ka2 RSK3 F1M7N7 rat BSN 12217 O88737 Bsn mouse S2860 456576 KTLQRsLsDPKPLsP X -Rps6ka2 RSK3 F1M7N7 rat BSN 29138 O88778 Bsn rat S2845 456576 KTLQRSLsDPKPLSP X -PKDCC PKDCC Q504Y2 human PKDCC 106522 Q5RJI4 Pkdcc mouse Y148 26375901 AQYVGSGyTKAVYRV X -PKDCC PKDCC Q504Y2 human PKDCC 106522 Q5RJI4 Pkdcc mouse S177 26375900 FSGHDLGsCVREFGA X -PKDCC PKDCC Q504Y2 human HDAC5 84580 F1LM64 Hdac5 rat S322 447996 RPLSRTQsSPLPQSP X -PKDCC PKDCC Q504Y2 human HDAC5 84580 F1LM64 Hdac5 rat S83 447995 FPLRKTAsEPNLKVR X -PHKA1 PHKA1 P46020 human PYGB 5834 P11216 PYGB human S15 456885 sEkRKQIsVRGLAGL X -Prkci PKCI F1M7Y5 rat ATP1A1 24211 P06685 Atp1a1 rat S16 449086 KyEPAAVsEHGDkks X 4020 -Prkci PKCI F1M7Y5 rat MARK2 60328 O08679 Mark2 rat T539 453427 RGVSSRStFHAGQLR X -Prkci PKCI F1M7Y5 rat ATP1A1 24211 P06685 Atp1a1 rat S23 449087 sEHGDkkskkAKKER X 4006 -Yes1 Yes F1LM93 rat Yes 24884 F1LM93 Yes1 rat Y424 447619 RLIEDNEyTARQGAk PK_Tyr_Ser-Thr X 2101; 6943; 59548; 70926; 78740; 94361; 17320 -Yes1 Yes F1LM93 rat Yes 24884 F1LM93 Yes1 rat Y32 454273 VNTSAGHyGVEHATA X -ULK3 ULK3 Q6PHR2 human ULK3 25989 Q6PHR2 ULK3 human S300 26395102 KKDQEGDsAAALsLY MIT X -ULK3 ULK3 Q6PHR2 human ULK3 25989 Q6PHR2 ULK3 human S350 26395101 ELkAIVSsSNQALLR X -ULK3 ULK3 Q6PHR2 human ULK3 25989 Q6PHR2 ULK3 human S464 19084302 DkEGLSEsVRSSCTL X -ULK3 ULK3 Q6PHR2 human ULK3 25989 Q6PHR2 ULK3 human S384 26395100 LAALEVAsAAMAKEE MIT X -ULK3 ULK3 Q6PHR2 human PIK3C3 5289 Q8NEB9 PIK3C3 human S249 35483209 ESsPILTsFELVKVP X 13857 -SGK2 SGK2 Q9HBY8 human PTOV1 53635 Q86YD1 PTOV1 human S53 4767655 PPRIRARsAPPMEGA X -SGK2 SGK2 Q9HBY8 human PTOV1 53635 Q86YD1 PTOV1 human S36 11138413 VRAVRsRsWPAsPRG X X -SGK2 SGK2 Q9HBY8 human L-plastin 3936 P13796 LCP1 human S5 450852 ___MARGsVsDEEMM X -SGK2 SGK2 Q9HBY8 human MDM2 4193 Q00987 MDM2 human S166 448130 SsRRRAIsEtEENsD X 3521 -PKN2 PKN2 Q16513 human eNOS 4846 P29474 NOS3 human S1179 467802 RIRtQsFsLQERQLR X X -PKN2 PKN2 Q16513 human pyrin 4210 O15553 MEFV human S208 455897 VRLRRNAssAGRLQG X -PKN2 PKN2 Q16513 human pyrin 4210 O15553 MEFV human S242 455899 SGKMRPRsLEVTIST X -pYV0094 yopH P08538 bacteria Lck 3932 P06239 LCK human Y394 447822 RLIEDNEytAREGAk PK_Tyr_Ser-Thr X 2101; 6943; 59548; 70926; 78740; 94361; 17320 -Akt1 Akt1 P47196 rat GSK3B 84027 P18266 Gsk3b rat S9 449111 SGRPRTTsFAESCKP X 9336; 9331; 9327; 9323; 9322; 9325; 5558; 8566; 79774; 8466; 25462; 14026; 14332; 14310; 14630 -Akt1 Akt1 P47196 rat FOXO1A 84482 G3V7R4 Foxo1 rat T24 448560 LPRQRSCtWPLPRPE X 9464 -Akt1 Akt1 P47196 rat Merlin 4771 P35240 NF2 human S315 487469 MRRRKADsLEVQQMk FERM_C X -Akt1 Akt1 P47196 rat acinus 305884 E9PST5 Acin1 rat S1180 456759 GPRSRSRsRDRRRKE RSB_motif X -Akt1 Akt1 P47196 rat IRS1 25467 P35570 Irs1 rat S522 447561 RFRKRTHsAGtsPTI X -Akt1 Akt1 P47196 rat FOXO1A 84482 G3V7R4 Foxo1 rat S313 449113 TFRPRTSsNAsTIsG X 2486 -Akt1 Akt1 P47196 rat S6 29304 P62755 Rps6 rat S235 448092 IAKRRRLssLRAsts X 5006; 4856; 4857; 4858; 4851; 4803; 2211; 3945; 3985; 5316; 4854; 8520; 48319; 40643; 9865; 38573; 14733; 27036; 34411; 62016; 62788; 81736; 97935; 99457; 15448 -Akt1 Akt1 P47196 rat PRPF19 27339 Q9UMS4 PRPF19 human T193 17331800 ERKKRGktVPEELVk X -Akt1 Akt1 P47196 rat eNOS 24600 Q62600 Nos3 rat S1176 447884 TSRIRtQsFsLQERQ X 9570 -Akt1 Akt1 P47196 rat AMPKA1 65248 P54645 Prkaa1 rat S496 450431 AtPQRSGsISNYRSC AdenylateSensor X 4185; 4184; 2537 -Akt1 Akt1 P47196 rat FOXO1A 84482 G3V7R4 Foxo1 rat S250 448075 sPRRRAAsMDNNSkF X 9461; 84192 -Akt1 Akt1 P47196 rat BAD 64639 O35147 Bad rat S137 447862 PFRGRsRsAPPNLWA Bcl-2_BAD X 9295; 5286; 4366 -Akt1 Akt1 P47196 rat RAF1 24703 P11345 Raf1 rat S259 447741 SQRQRSTsTPNVHMV X 9421; 20011 -Akt1 Akt1 P47196 rat Bcl-xL 24888 P53563 Bcl2l1 rat S106 5014911 LRYRRAFsDLTSQLH Bcl-2 X -Akt1 Akt1 P47196 rat FOXO3A 294515 D3ZBQ1 Foxo3 rat S252 449108 APRRRAVsMDNSNkY X 9466; 13129 -Akt1 Akt1 P47196 rat RPS3 6188 P23396 RPS3 human T70 15113600 GrrIrELtAVVQkRF KH_2 X -Akt1 Akt1 P47196 rat Merlin 4771 P35240 NF2 human T230 487468 AIRNKKGtELLLGVD FERM_C X -Akt1 Akt1 P47196 rat FOXO3A 2309 O43524 FOXO3 human T32 448602 QsRPRsCtWPLQRPE X 2599; 9464 -Akt1 Akt1 P47196 rat AMPKA2 78975 Q09137 Prkaa2 rat S491 450432 StPQRSCsAAGLHRP AdenylateSensor X 4185 -Akt1 Akt1 P47196 rat PRAS40 292887 D3ZH75 Akt1s1 rat T247 470067 LPRPRLNtSDFQKLK PRAS X 2640; 2997; 32263; 13175; 60202 -Akt1 Akt1 P47196 rat S6 29304 P62755 Rps6 rat S236 448093 AKRRRLssLRAstsK X 5006; 4856; 4857; 4858; 4851; 4803; 2211; 3945; 3985; 5316; 4854; 8520; 48319; 40643; 9865; 38573; 14733; 27036; 34411; 62016; 62788; 81736; 97935; 99457; 15448 -Akt1 Akt1 P47196 rat FOXO3A 294515 D3ZBQ1 Foxo3 rat T32 448602 QSRPRSCtWPLQRPE X 9464 -Akt1 Akt1 P47196 rat lamin A/C 60374 P48679 Lmna rat S404 478681 RSRGRAssHssQSQG X -Akt1 Akt1 P47196 rat FOXO3A 2309 O43524 FOXO3 human S253 449108 APRRRAVsMDNSNkY X 9466; 13129 -Akt1 Akt1 P47196 rat PLB 64672 P61016 Pln rat S16 448114 RSAIRRAstIEMPQQ Phospholamban X 8496 -MARK2 MARK2 Q7KZI7 human PAR3-alpha 81918 Q9Z340 Pard3 rat S852 1983958 VKTRKSKsMDLGIAD X X -MARK2 MARK2 Q7KZI7 human KIF13B 23303 Q9NQT8 KIF13B human S1410 482224 SNKGRWEsQQDVsQT X X -MARK2 MARK2 Q7KZI7 human ARHGEF2 9181 Q92974 ARHGEF2 human S186 1220712 NMRNRtLsVEsLIDE X X -MARK2 MARK2 Q7KZI7 human RAB11FIP2 22841 Q7L804 RAB11FIP2 human S227 465674 QRLsSAHsMsDLSGS X X -MARK2 MARK2 Q7KZI7 human KCNK18 332396 Q6VV64 Kcnk18 mouse S279 13383301 RLsCsILsNLDEVGQ X -MARK2 MARK2 Q7KZI7 human PAR3-alpha 81918 Q9Z340 Pard3 rat S144 455668 PLHVRRssDPALtGL X -MARK2 MARK2 Q7KZI7 human Tau iso8 4137 P10636-8 MAPT human S262 447930 NVKskIGstENLkHQ Tubulin-binding X X -MARK2 MARK2 Q7KZI7 human HDAC4 9759 P56524 HDAC4 human S467 448489 RPLGRtQsAPLPQNA X -MARK2 MARK2 Q7KZI7 human Tau iso8 4137 P10636-8 MAPT human S324 449328 kVtskCGsLGNIHHk Tubulin-binding X -MARK2 MARK2 Q7KZI7 human PSD-95 1742 P78352 DLG4 human S561 25680400 EFPDKFGsCVPHTTR Guanylate_kin X X -MARK2 MARK2 Q7KZI7 human MST2 6788 Q13188 STK3 human S15 4272103 KSKLKkLsEDsLTkQ X X -MARK2 MARK2 Q7KZI7 human ARHGEF2 iso2 9181 Q92974-2 ARHGEF2 human S885 451365 PVDPRRRsLPAGDAL X X 14143 -MARK2 MARK2 Q7KZI7 human PINK1 65018 Q9BXM7 PINK1 human T313 23003808 EGLGHGRtLFLVMkN Pkinase X X -MARK2 MARK2 Q7KZI7 human utrophin 7402 P46939 UTRN human S1258 2525745 TLEERMKsTEVLPEk X X -MARK2 MARK2 Q7KZI7 human ARHGEF2 9181 Q92974 ARHGEF2 human S143 10991696 GsRRGRssLsLAksV X X -MARK2 MARK2 Q7KZI7 human RAB11FIP1 iso3 80223 Q6WKZ4-3 RAB11FIP1 human S234 4691719 QKTPLSQsMSVLPTS X X -MARK2 MARK2 Q7KZI7 human HDAC7 51564 Q8WUI4 HDAC7 human S155 455620 FPLRKtVsEPNLkLR X 3443 -MARK2 MARK2 Q7KZI7 human HDAC4 9759 P56524 HDAC4 human S246 448488 FPLRkTAsEPNLKLR X X 3443 -MARK2 MARK2 Q7KZI7 human PAR3-alpha 56288 Q8TEW0 PARD3 human S873 3207429 VDDQKAGsPsRDVGP X -MARK2 MARK2 Q7KZI7 human MARK2 2011 Q7KZI7 MARK2 human S400 5635600 HkVQRsVsANPKQRR X -MARK2 MARK2 Q7KZI7 human FAK 5747 Q05397 PTK2 human Y397 447887 sVsEtDDyAEIIDEE X 3283; 8556 -MARK2 MARK2 Q7KZI7 human ARHGEF2 iso2 9181 Q92974-2 ARHGEF2 human S959 467500 SRLSPPHsPRDFTRM X -MARK2 MARK2 Q7KZI7 human Tau iso8 4137 P10636-8 MAPT human S356 449104 rVQskIGsLDNItHV Tubulin-binding X -MARK2 MARK2 Q7KZI7 human TORC2 74343 Q3U182 Crtc2 mouse S171 454622 sALNRtSsDsALHTs TORC_M X -MARK2 MARK2 Q7KZI7 human FEZ1 9638 Q99689 FEZ1 human S58 454522 SEIISFKsMEDLVNE FEZ X X -MARK2 MARK2 Q7KZI7 human RNF41 10193 Q9H4P4 RNF41 human S254 29675602 IENAHERsWPQGLAT USP8_interact X -MARK2 MARK2 Q7KZI7 human MRLC1 10398 P24844 MYL9 human S20 1863500 KRPQRAtsNVFAMFD X X 3674; 3671; 3675; 95777 -MARK2 MARK2 Q7KZI7 human IRSp53 10458 Q9UQB8 BAIAP2 human S366 468035 ktLPRsssMAAGLER X -MARK2 MARK2 Q7KZI7 human KCNK18 332396 Q6VV64 Kcnk18 mouse S274 13383300 ELVLGRLsCsILsNL X X -MARK2 MARK2 Q7KZI7 human ARHGEF2 9181 Q92974 ARHGEF2 human S172 460815 LGLRRILsQstDsLN X X -MARK2 MARK2 Q7KZI7 human HDAC5 10014 Q9UQL6 HDAC5 human S259 447995 FPLRkTAsEPNLKVR X 3443 -MARK2 MARK2 Q7KZI7 human PAR3-alpha 56288 Q8TEW0 PARD3 human S144 455668 PLHVRRssDPALIGL X -MARK2 MARK2 Q7KZI7 human KCNK18 332396 Q6VV64 Kcnk18 mouse S276 12525800 VLGRLsCsILsNLDE X X -MARK2 MARK2 Q7KZI7 human Tau 17762 P10637 Mapt mouse S554 447930 NVRSkIGstENLKHQ Tubulin-binding X -MARK2 MARK2 Q7KZI7 human TORC2 74343 Q3U182 Crtc2 mouse S275 3174300 PAMNTGGsLPDLTNL TORC_M X X -MARK2 MARK2 Q7KZI7 human eIF2-alpha 1965 P05198 EIF2S1 human S52 447635 MILLsELsRRRIRsI S1 X X 3597; 9721; 3398; 5199; 53085; 95797 -MARK2 MARK2 Q7KZI7 human TORC2 74343 Q3U182 Crtc2 mouse S307 454633 PSLSGGNsTTNLTHT TORC_M X -MARK2 MARK2 Q7KZI7 human KIF13B 23303 Q9NQT8 KIF13B human S1381 4691956 KLSRRsIssPNVNRL X X -Camk4 CAMK4 P13234 rat QIK 315649 Q3LRT3 Sik2 rat T484 478056 RSGQRRHtLSEVTNQ X -Camk4 CAMK4 P13234 rat Calmodulin 24242 P0DP29 Calm3 rat T45 469598 RSLGQNPtEAELQDM EF-hand_7 X -Camk4 CAMK4 P13234 rat NUMB 8650 P49757 NUMB human S276 456490 EQLARQGsFrGFPAL NumbF X 4140; 9878 -Camk4 CAMK4 P13234 rat ADCY1 281601 P19754 ADCY1 cow S552 451156 sEKLRNRsSFSTNVV X -Camk4 CAMK4 P13234 rat CAMK4 25050 P13234 Camk4 rat S437 451566 DQEMKRNsEETLKsV X -Camk4 CAMK4 P13234 rat ADCY1 281601 P19754 ADCY1 cow S545 451155 RRALRTAsEKLRNRs X -Camk4 CAMK4 P13234 rat NUMBL 292732 A1L1I3 Numbl rat S305 456489 EQLVRQGsFRGFPAL NumbF X -CLK2 CLK2 P49760 human PPP2R5B 225849 Q6PD28 Ppp2r5b mouse S32 31895400 PDKVDGFsRRsLRRA X X -CLK2 CLK2 P49760 human PAGE4 9506 O60829 PAGE4 human S7 63280104 _MSARVRsRsRGrGD GAGE X -CLK2 CLK2 P49760 human CK1D 64462 Q06486 Csnk1d rat S370 483997 MERERKVsMRLHRGA X -CLK2 CLK2 P49760 human PAGE4 9506 O60829 PAGE4 human S73 63280106 MDLEKtRsERGDGsD GAGE X -CLK2 CLK2 P49760 human PPP2R5B 225849 Q6PD28 Ppp2r5b mouse S48 23134678 PRRsHsssQFRyQSN X X -CLK2 CLK2 P49760 human PPP2R5B 225849 Q6PD28 Ppp2r5b mouse S46 18261152 ARPRRsHsssQFRyQ X X -CLK2 CLK2 P49760 human PTP1B 5770 P18031 PTPN1 human S243 9921201 DKRkDPssVDIkKVL Y_phosphatase X -CLK2 CLK2 P49760 human PAGE4 9506 O60829 PAGE4 human S79 63280102 RsERGDGsDVKEKtP GAGE X -CLK2 CLK2 P49760 human PAGE4 9506 O60829 PAGE4 human T71 63280103 QEMDLEKtRsERGDG GAGE X -CLK2 CLK2 P49760 human PPP2R5B 225849 Q6PD28 Ppp2r5b mouse S44 10405463 RRARPRRsHsssQFR X X -CLK2 CLK2 P49760 human PAGE4 9506 O60829 PAGE4 human T85 15421970 GsDVKEKtPPNPKHA GAGE X -CLK2 CLK2 P49760 human PTP1B 5770 P18031 PTPN1 human S50 447811 RNRyRDVsPFDHsRI Y_phosphatase X -CLK2 CLK2 P49760 human PAGE4 9506 O60829 PAGE4 human T94 63280105 PNPKHAKtKEAGDGQ GAGE X -CLK2 CLK2 P49760 human PAGE4 9506 O60829 PAGE4 human T51 3913886 PGQEREGtPPIEERK GAGE X -CLK2 CLK2 P49760 human PAGE4 9506 O60829 PAGE4 human S9 63280101 SARVRsRsRGrGDGQ GAGE X -CLK2 CLK2 P49760 human PPP2R5B 225849 Q6PD28 Ppp2r5b mouse S47 10405468 RPRRsHsssQFRyQS X X -CLK2 CLK2 P49760 human PTP1B 5770 P18031 PTPN1 human S242 9921200 MDKRkDPssVDIkKV Y_phosphatase X -CLK2 CLK2 P49760 human PPP2R5B 225849 Q6PD28 Ppp2r5b mouse S35 10405458 VDGFsRRsLRRARPR X X -Lrrk2 LRRK2 Q5S006 mouse RAB12 19328 P35283 Rab12 mouse S105 487152 AGQERFNsITSAYYR Ras X -Lrrk2 LRRK2 Q5S006 mouse RAB10 19325 P61027 Rab10 mouse T73 471953 AGQERFHtITTSYYR Ras X -Lrrk2 LRRK2 Q5S006 mouse SYN1 24949 P09951 Syn1 rat T339 2020533 sGNWKtNtGsAMLEQ Synapsin_C X -Lrrk2 LRRK2 Q5S006 mouse SYN1 24949 P09951 Syn1 rat T337 486180 SVsGNWKtNtGsAML Synapsin_C X -Akt3 Akt3 Q63484 rat GJA1 24392 P08050 Gja1 rat S373 459209 RAssRAssRPRPDDL X -BAZ1B WSTF Q9UIG0 human H2AX 3014 P16104 H2AX human Y142 3397700 AtQAsQEy_______ X 5438 -BAZ1B WSTF Q9UIG0 human H2AX 15270 P27661 H2ax mouse Y142 3397700 AsQAsQEy_______ X 5438 -SGK1 SGK1 O00141 human NHE3 100009430 P26432 NHE-3 rabbit S663 457469 TMRKRLEsFKSAKLG X -SGK1 SGK1 O00141 human NEDD4L 23327 Q96PU5 NEDD4L human S342 453438 ssRLRsCsVtDAVAE X X 12146 -SGK1 SGK1 O00141 human AS160 9882 O60343 TBC1D4 human S318 455925 EFRsRCssVtGVQRR PID X 8619 -SGK1 SGK1 O00141 human SHANK2 iso7 171093 Q9QX74-7 Shank2 rat S477 33668500 GPRSRSPsLNRLGGA X -SGK1 SGK1 O00141 human NDRG2 57447 Q9UN36 NDRG2 human T330 454243 tRLsRsRtAsLtsAA X X -SGK1 SGK1 O00141 human AMPKA2 108079 Q8BRK8 Prkaa2 mouse S491 450432 stPQRSCsAAGLHRA AdenylateSensor X X -SGK1 SGK1 O00141 human NEDD4L 83814 Q8CFI0 Nedd4l mouse S371 453438 sSRLRsCsVTDTVAE X 12146 -SGK1 SGK1 O00141 human TRPV4 63873 Q9EPK8 Trpv4 mouse S824 4777181 LRRDRWssVVPRVVE X -SGK1 SGK1 O00141 human Fe65 29722 P46933 Apbb1 rat S611 2035401 ECRVRFLsFLAVGRD PID X -SGK1 SGK1 O00141 human nicastrin 23385 Q92542 NCSTN human S437 25533000 FLRArNIsGVVLADH Nicastrin X -SGK1 SGK1 O00141 human NDRG2 57447 Q9UN36 NDRG2 human S346 454244 VDGNRsRsRtLsQss X -SGK1 SGK1 O00141 human p27Kip1 1027 P46527 CDKN1B human T157 448645 GIRkrPAtDDSSTQN X X -SGK1 SGK1 O00141 human MLL4 iso3 8085 O14686-3 KMT2D human S1331 1217705 RGRARLKsTASSIET X X -SGK1 SGK1 O00141 human ELK1 314436 A4GTP4 Elk1 rat S159 2028400 YMRSGLYstFTIQSL X X -SGK1 SGK1 O00141 human SRF 501099 D3ZHH8 Srf rat S99 447692 RGLKRSLsEMELGVV X -SGK1 SGK1 O00141 human NLRP3 216799 Q8R4B8 Nlrp3 mouse S3 38492201 _____MTsVRCKLAQ X -SGK1 SGK1 O00141 human NEDD4L 83814 Q8CFI0 Nedd4l mouse S477 453440 IRRPRsLssPtVtLS X 8063 -SGK1 SGK1 O00141 human Mnk1 iso2 8569 Q9BUB5-2 MKNK1 human S353 56790200 QVLQRNSsTMDLTLF X -SGK1 SGK1 O00141 human GSK3B 2932 P49841 GSK3B human Y216 448569 RGEPNVsyICsRyyR Pkinase X X -SGK1 SGK1 O00141 human FOXO3A 2309 O43524 FOXO3 human S315 449109 DFRsRTNsNAstVsG X -SGK1 SGK1 O00141 human NEDD4L 23327 Q96PU5 NEDD4L human S448 453440 IRRPRsLssPtVtLS X X 8063 -SGK1 SGK1 O00141 human ERK2 5594 P28482 MAPK1 human S29 7989100 GPRyTNLsYIGEGAy Pkinase X -SGK1 SGK1 O00141 human CREB iso1 81646 P15337-1 Creb1 rat S133 448228 EILsRRPsYRkILND pKID X X 9187; 9196; 9198; 4095; 14228; 14001; 39561; 80120; 44864; 54960; 95995 -SGK1 SGK1 O00141 human TSC2 7249 P49815 TSC2 human S981 454014 AFRCRSIsVSEHVVR X X -SGK1 SGK1 O00141 human MEKK3 26406 Q61084 Map3k3 mouse S166 3188100 EPRSRHLsVsSQNPG X X -SGK1 SGK1 O00141 human AS160 9882 O60343 TBC1D4 human S570 455923 AKRsLtssLENIFsr X -SGK1 SGK1 O00141 human MKK4 6416 P45985 MAP2K4 human S80 447655 IERLRtHsIESSGkL X 9155 -SGK1 SGK1 O00141 human TSC2 7249 P49815 TSC2 human S1130 448499 GARDRVRsMsGGHGL X X -SGK1 SGK1 O00141 human WNK4 65266 Q96J92 WNK4 human S1190 477191 SSRQRRLsKGSFPTS X X -SGK1 SGK1 O00141 human NDRG1 10397 Q92597 NDRG1 human T366 454246 GtRsRsHtsEGAHLD X X -SGK1 SGK1 O00141 human Tau 29477 P19332 Mapt rat S525 447929 GsRSRtPsLPtPPTR X 77348 -SGK1 SGK1 O00141 human Huntingtin 3064 P42858 HTT human S419 448106 GGRsRsGsIVELIAG X X -SGK1 SGK1 O00141 human ELK1 314436 A4GTP4 Elk1 rat T160 2028401 MRSGLYstFTIQSLQ X X -SGK1 SGK1 O00141 human FBXW7 55294 Q969H0 FBXW7 human S227 17792400 QQRRRITsVQPPTGL X X -SGK1 SGK1 O00141 human ENaC-alpha 25122 P37089 Scnn1a rat S621 454020 RFRsRYWsPGRGARG X -SGK1 SGK1 O00141 human IkB-alpha 4792 P25963 NFKBIA human S32 448203 LLDDRHDsGLDsMkD X 5210; 2859; 9246; 5209 -SGK1 SGK1 O00141 human MEKK3 26406 Q61084 Map3k3 mouse S337 468184 DPRGRLRsADsENAL X X -SGK1 SGK1 O00141 human Fe65 322 O00213 APBB1 human S610 2035401 ECRVRFLsFLAVGRD PID X -SGK1 SGK1 O00141 human NDRG1 10397 Q92597 NDRG1 human T346 454245 GtRsRsHtsEGtRsR X X 3217; 5482; 6992; 7497; 8947; 89166 -SGK1 SGK1 O00141 human NDRG1 10397 Q92597 NDRG1 human T356 454247 GtRsRsHtsEGtRsR X X -SGK1 SGK1 O00141 human TSC2 7249 P49815 TSC2 human T1462 448546 GLrPrGytISDsAPs X X 3617; 3611 -SGK1 SGK1 O00141 human NDRG2 57447 Q9UN36 NDRG2 human T348 451009 GNRsRsRtLsQssEs X X -SGK1 SGK1 O00141 human CREB 1385 P16220 CREB1 human S119 448228 EILsRRPsyRkILND pKID X 9187; 9196; 9198; 4095; 14228; 14001; 39561; 80120; 44864; 54960; 95995 -SGK1 SGK1 O00141 human NEDD4L 23327 Q96PU5 NEDD4L human T367 453439 AGRARsstVtGGEEP X -SGK1 SGK1 O00141 human TSC2 7249 P49815 TSC2 human S939 448501 sFRARstsLNERPKs X X 3615 -SGK1 SGK1 O00141 human GSK3B 2932 P49841 GSK3B human S9 449111 SGRPRttsFAEsCkP X 9336; 9331; 9327; 9323; 9322; 9325; 5558; 8566; 79774; 8466; 25462; 14026; 14332; 14310; 14630 -SGK1 SGK1 O00141 human Kaiso 10009 Q86T24 ZBTB33 human T606 34353150 yLSDRSStIPAMkDD X -SGK1 SGK1 O00141 human NDRG2 57447 Q9UN36 NDRG2 human S332 451010 LsRsRtAsLtsAAsV X X -SGK1 SGK1 O00141 human AS160 9882 O60343 TBC1D4 human S751 455924 EGRKRtsstCsNEsL X -SGK1 SGK1 O00141 human MDM2 4193 Q00987 MDM2 human S166 448130 SsRRRAIsEtEENsD X 3521 -SGK1 SGK1 O00141 human Tau iso8 4137 P10636-8 MAPT human S214 447929 GsRsRtPsLPtPPtR X X 77348 -SGK1 SGK1 O00141 human AS160 9882 O60343 TBC1D4 human S341 455922 QPRRRHAsAPsHVQP PID X -SGK1 SGK1 O00141 human p27Kip1 1027 P46527 CDKN1B human T198 448781 PGLRRRQt_______ X -SGK1 SGK1 O00141 human TSC2 7249 P49815 TSC2 human S1798 454016 GQRKRLIssVEDFTE X X -SGK1 SGK1 O00141 human SGK1 6446 O00141 SGK1 human S422 448429 AEAFLGFsYAPPTDS Pkinase_C X X -SGK1 SGK1 O00141 human SLC1A6 84012 O35921 Slc1a6 rat T40 480172 RTRLRLQtMTREHVR X -SGK1 SGK1 O00141 human AMPKA2 108079 Q8BRK8 Prkaa2 mouse T485 8090273 EQRsGSstPQRSCsA AdenylateSensor X -SGK1 SGK1 O00141 human CARHSP1 23589 Q9Y2V2 CARHSP1 human S52 453062 tRRtrtFsAtVRAsQ X -SGK1 SGK1 O00141 human WNK1 65125 Q9H4A3 WNK1 human T60 450948 EYRRRRHtMDKDSrG X 4946 -SGK1 SGK1 O00141 human AS160 9882 O60343 TBC1D4 human T642 455921 QFRRRAHtFsHPPss X 4288; 8881 -SGK1 SGK1 O00141 human GLUT4 6517 P14672 SLC2A4 human S274 478418 LERERPLsLLQLLGs Sugar_tr X -SGK1 SGK1 O00141 human NDRG1 10397 Q92597 NDRG1 human S330 452879 LMRsRtAsGssVtsL X X 3506; 11899 -SGK1 SGK1 O00141 human AS160 9882 O60343 TBC1D4 human T568 486326 NKAKRsLtssLENIF X -SGK1 SGK1 O00141 human AS160 9882 O60343 TBC1D4 human S588 455920 RMRGRLGsVDsFERs X 8730 -SGK1 SGK1 O00141 human WNK4 69847 Q80UE6 Wnk4 mouse S1196 5879855 PGIMRRNsLSGSSTG X -SGK1 SGK1 O00141 human GDI1 25183 P50398 Gdi1 rat S213 12607403 INrIkLYsESLARYG GDI X -SGK1 SGK1 O00141 human TSC2 7249 P49815 TSC2 human S1132 448500 RDRVRsMsGGHGLRV X X -SGK1 SGK1 O00141 human NEDD4L 83814 Q8CFI0 Nedd4l mouse T396 453439 TRRARSStVTGGEEP X -SGK1 SGK1 O00141 human AS160 9882 O60343 TBC1D4 human S666 486327 GRAQGVRsPLLRQSS X -SGK1 SGK1 O00141 human WNK4 65266 Q96J92 WNK4 human S1201 23073728 FPTSRRNsLQRSEPP X X -SGK1 SGK1 O00141 human FOXO3A 56484 Q9WVH4 Foxo3 mouse T32 448602 QSRPRSCtWPLQRPE X 9464 -SGK1 SGK1 O00141 human PIKFYVE 200576 Q9Y2I7 PIKFYVE human S318 3216759 LsLDRsGsPMVPSyE X -SGK1 SGK1 O00141 human RICTOR 253260 Q6R327 RICTOR human T1135 458276 NRRIRtLtEPsVDFN RICTOR_phospho X 3806 -SGK1 SGK1 O00141 human IKKB 3551 O14920 IKBKB human S181 447489 DQGsLCtsFVGTLQy Pkinase X 2697; 2694; 14938; 92255; 36516; 36214 -SGK1 SGK1 O00141 human NDRG1 10397 Q92597 NDRG1 human T328 452881 TRLMRsRtAsGssVt X -SGK1 SGK1 O00141 human WNK4 69847 Q80UE6 Wnk4 mouse S1169 477191 SCRQRRLsKGsFPTS X X -SGK1 SGK1 O00141 human WNK4 65266 Q96J92 WNK4 human S1217 5879855 PGIMRRNsLSGSStG X X -Pik3ca PIK3CA P42337 mouse CEACAM1 26365 P31809 Ceacam1 mouse Y515 451429 PRAtETVysEVkKK_ X -JAK1 JAK1 P23458 human SIRT1 23411 Q96EB6 SIRT1 human Y280 25311269 FRSRDGIyARLAVDF SIR2 X -JAK1 JAK1 P23458 human PERK 9451 Q9NZJ5 EIF2AK3 human Y585 35518100 NDIkNSGyISRYLTD X X -JAK1 JAK1 P23458 human HADHA 3030 P40939 HADHA human Y499 55372195 EKVIGMHyFsPVDkM 3HCDH_N X -JAK1 JAK1 P23458 human TRPV2 29465 Q9WUD2 Trpv2 rat Y335 1877505000 RKFTEWCyGPVRVSL X X -JAK1 JAK1 P23458 human STAT5A 6776 P42229 STAT5A human Y694 447767 LAkAVDGyVkPQIkQ X 9365; 9356; 9359; 9351; 4322; 9314; 3939; 40284; 5387; 14603; 66740; 51879; 72712 -JAK1 JAK1 P23458 human HADHA 3030 P40939 HADHA human Y271 1883585000 LVEKLTAyAMTIPFV X -JAK1 JAK1 P23458 human RIPK1 8737 Q13546 RIPK1 human Y384 451864 kLQDEANyHLyGsRM X -JAK1 JAK1 P23458 human TRPV2 29465 Q9WUD2 Trpv2 rat Y471 1877505002 WISFMDSyFEILFLL Ion_trans X -JAK1 JAK1 P23458 human SNX8 29886 Q9Y5X2 SNX8 human Y126 348335701 MLLHkFPyRMVPALP PX X -JAK1 JAK1 P23458 human HADHA 3030 P40939 HADHA human Y435 55372191 NLTGQLDyQGFEKAD 3HCDH_N X -JAK1 JAK1 P23458 human ASK1 4217 Q99683 MAP3K5 human Y718 458209 IPERDSRySQPLHEE Pkinase X -JAK1 JAK1 P23458 human STAT3 20848 P42227 Stat3 mouse Y705 448192 DPGsAAPyLktkFIC X 4093; 9145; 4324; 9131; 9138; 4323; 4074; 4113; 48313; 20977; 25023; 8119; 52075; 52527; 73533; 61958; 73452; 16185; 74309 -JAK1 JAK1 P23458 human H3 8350 P68431 H3C1 human Y41 10897613 GVkkPHryrPGtVAL Histone X -JAK1 JAK1 P23458 human PERK 9451 Q9NZJ5 EIF2AK3 human Y619 1256400 NKVDDCNyAIkRIRL Pkinase X X -JAK1 JAK1 P23458 human STAT5A 20850 P42230 Stat5a mouse Y694 447767 LAKAVDGyVkPQIKQ X 9365; 9356; 9359; 9351; 4322; 9314; 3939; 40284; 5387; 14603; 66740; 51879; 72712 -JAK1 JAK1 P23458 human TRPV2 29465 Q9WUD2 Trpv2 rat Y525 2527084 GFQHTGIySVMIQKV Ion_trans X -JAK1 JAK1 P23458 human SIRT1 23411 Q96EB6 SIRT1 human Y301 25311272 QAMFDIEyFRKDPRP SIR2 X -JAK1 JAK1 P23458 human HADHA 3030 P40939 HADHA human Y43 1883601202 LTRTHINyGVkGDVA X -JAK1 JAK1 P23458 human SNX8 29886 Q9Y5X2 SNX8 human Y95 348335702 LFLKHVEyEVSSQRF X -JAK1 JAK1 P23458 human PD-L1 29126 Q9NZQ7 CD274 human Y112 1015586 KLQDAGVyRCMISYG V-set X X -JAK1 JAK1 P23458 human STAT1 6772 P42224 STAT1 human Y701 447754 DGPkGtGyIktELIs X 9174; 9167; 5375; 25685; 8062; 8183; 8009; 55603; 7649; 25809; 57216; 45118; 39205; 88845; 88211; 76285; 90145 -TAF1 TAF1 P21675 human GTF2A1 2957 P52655 GTF2A1 human S316 448629 VEEEPLNsEDDVsDE TFIIA X X -TAF1 TAF1 P21675 human GTF2A1 2957 P52655 GTF2A1 human S321 448630 LNsEDDVsDEEGQEL TFIIA X X -TAF1 TAF1 P21675 human TAF7 6879 Q15545 TAF7 human S264 468898 LQDKLNEsDEQHQEN X X -TAF1 TAF1 P21675 human p53 7157 P04637 TP53 human T55 450685 DDIEQWFtEDPGPDE TAD2 X X -MASTL MASTL Q96GX5 human ENSA 2029 O43768 ENSA human S67 455934 kGQkyFDsGDyNMAk Endosulfine X 5240 -MASTL MASTL Q96GX5 human ARPP-19 10776 P56211 ARPP19 human S62 465742 kGQkyFDsGDyNMAk Endosulfine X 5240 -Cdk1 CDK1 P39951 rat Caldesmon 25687 Q62736 Cald1 rat T468 448467 SsPSASGtPNKETAG Caldesmon X -Cdk1 CDK1 P39951 rat VCIP135 286761 Q8CF97 Vcpip1 rat S130 40642201 NYHCKLLsPILARYG VCIP135_N X X -Cdk1 CDK1 P39951 rat Caldesmon 25687 Q62736 Cald1 rat S462 448464 EKGSVFSsPSASGtP Caldesmon X -Cdk1 CDK1 P39951 rat Caldesmon 25687 Q62736 Cald1 rat S491 448468 INEWLTksPDGNKsP Caldesmon X -Cdk1 CDK1 P39951 rat NMDAR1 24408 P35439 Grin1 rat S584 1871177708 LYLLDRFsPFGRFKV Lig_chan X X -Cdk1 CDK1 P39951 rat PKLR iso2 24651 P12928-2 Pklr rat S113 31084572 ATESFATsPLSYRPV PK X X -Cdk1 CDK1 P39951 rat Src 396442 P00523 SRC chicken T34 455775 GGFPASQtPNKTAAP X -Cdk1 CDK1 P39951 rat APP 54226 P08592 App rat T743 448523 VEVDAAVtPEERHLS APP_amyloid X 3823; 6986 -Cdk1 CDK1 P39951 rat Caldesmon 25687 Q62736 Cald1 rat S497 448465 ksPDGNKsPAPkPSD Caldesmon X -Cdk1 CDK1 P39951 rat Src 396442 P00523 SRC chicken T46 455776 AAPDTHRtPsRSFGT X -Cdk1 CDK1 P39951 rat STMN2 84510 P21818 Stmn2 rat S73 450173 EAPRTLAsPKKkDLs Stathmin X -Cdk1 CDK1 P39951 rat Caldesmon 25687 Q62736 Cald1 rat S527 448466 QSVDKVTsPTKV___ X -Cdk1 CDK1 P39951 rat Src 396442 P00523 SRC chicken S72 450326 NTSDTVTsPQRAGAL X -Cdk1 CDK1 P39951 rat NMDAR2A 24409 Q00959 Grin2a rat S580 1871177709 VFVFEYFsPVGYNRN Lig_chan X X -Cdk1 CDK1 P39951 rat Caldesmon 25687 Q62736 Cald1 rat S249 450134 KQTENAFsPSRSGGR Caldesmon X -Cdk1 CDK1 P39951 rat BAD 64639 O35147 Bad rat S129 447861 EGMEEELsPFRGRsR Bcl-2_BAD X X -ABL1 Abl P00519 human YAP1 10413 P46937 YAP1 human Y407 473004 sGLsMsSySVPRtPD X X -ABL1 Abl P00519 human SOS1 20662 Q62245 Sos1 mouse Y1182 34550593 SKAYsPRysISDRTS X X -ABL1 Abl P00519 human DCBLD2 131566 Q96PD2 DCBLD2 human Y750 454600 PAPDELVyQVPQStQ X -ABL1 Abl P00519 human SMAD4 4089 Q13485 SMAD4 human Y301 1881244702 MPPHPGHyWPVHNEL X X -ABL1 Abl P00519 human DCBLD1 285761 Q8N8Z6 DCBLD1 human S657 25735581 GDyQRPHsAQPADRG X -ABL1 Abl P00519 human TBX21 30009 Q9UL17 TBX21 human Y305 20583305 QFIAVTAyQNAEITQ T-box X X -ABL1 Abl P00519 human Catalase 847 P04040 CAT human Y231 450444 NANGEAVyCkFHYkT Catalase X X -ABL1 Abl P00519 human smMLCK 4638 Q15746 MYLK human Y1449 4739881 EKEPEVDyRTVTINT X -ABL1 Abl P00519 human Abl 25 P00519 ABL1 human Y393 450298 RLMtGDtytAHAGAk PK_Tyr_Ser-Thr X X 2865 -ABL1 Abl P00519 human p73 7161 O15350 TP73 human Y99 448428 SVPTHSPyAQPSSTF X X 4665 -ABL1 Abl P00519 human DCBLD2 131566 Q96PD2 DCBLD2 human Y715 455062 PPPLVGtyNtLLsRt X -ABL1 Abl P00519 human ArgBP2 iso2 8470 O94875-2 SORBS2 human Y59 31834901 RPFSPSAySLPASLN X -ABL1 Abl P00519 human DCBLD2 131566 Q96PD2 DCBLD2 human Y565 458665 KKkTEGtyDLPyWDR X -ABL1 Abl P00519 human TOP1 21969 Q04750 Top1 mouse Y270 454026 AKMLDHEytTKEIFR Topoisom_I_N X -ABL1 Abl P00519 human CDC73 79577 Q6P1J9 CDC73 human Y315 15402684 KIDTMGTyHGMTLkS X -ABL1 Abl P00519 human Abi-1 11308 Q8CBW3 Abi1 mouse Y213 449523 PPTVPNDyMtsPARL X -ABL1 Abl P00519 human Catalase 12359 P24270 Cat mouse Y386 450445 yRARVANyQRDGPMC Catalase X -ABL1 Abl P00519 human DCBLD1 285761 Q8N8Z6 DCBLD1 human S695 1869653004 THPGTsDsysAPRDC X -ABL1 Abl P00519 human Met 4233 P08581 MET human Y1349 448472 stFIGEHyVHVNAty X 3133; 3121 -ABL1 Abl P00519 human HRas 3265 P01112 HRAS human Y137 41198101 AQDLARSyGIPYIEt Ras X -ABL1 Abl P00519 human Myc 4609 P01106 MYC human Y89 17553985 sGLCsPSyVAVtPFs Myc_N X -ABL1 Abl P00519 human BMPR1A 12166 P36895 Bmpr1a mouse Y458 25655002 EEyQLPyyNMVPSDP PK_Tyr_Ser-Thr X -ABL1 Abl P00519 human DAB1 13131 P97318 Dab1 mouse Y232 447961 SQKKEGVyDVPKSQP X 3325 -ABL1 Abl P00519 human MDM4 4194 O15151 MDM4 human Y55 6039501 TVKEVMHyLGQYIMV SWIB X -ABL1 Abl P00519 human BCAP 118788 Q6ZUJ8 PIK3AP1 human Y513 3971796 LGQEEDVyHTVDDDE X -ABL1 Abl P00519 human PDGFRB 5159 P09619 PDGFRB human Y970 4833940 GEGYKKKyQQVDEEF X -ABL1 Abl P00519 human Tip60 10524 Q92993 KAT5 human Y294 29431804 HPPGNEIyRkGTISF MOZ_SAS X X -ABL1 Abl P00519 human JAK2 16452 Q62120 Jak2 mouse Y1008 448408 LPQDKEyyKVKEPGE PK_Tyr_Ser-Thr X 3771; 3776; 8082; 66245; 32901 -ABL1 Abl P00519 human Myc 4609 P01106 MYC human Y47 27530806 CDEEENFyQQQQQSE Myc_N X -ABL1 Abl P00519 human CRK 1398 P46108 CRK human Y221 447951 GGPEPGPyAQPsVNt X X 3491 -ABL1 Abl P00519 human CASP9 842 P55211 CASP9 human Y153 455198 RGNADLAyILSMEPC X X -ABL1 Abl P00519 human PLSCR1 5359 O15162 PLSCR1 human Y69 2915403 PVPNQPVyNQPVyNQ X -ABL1 Abl P00519 human Rin1 225870 Q921Q7 Rin1 mouse Y35 450778 KPstDPLyDTPDTRG X -ABL1 Abl P00519 human ANXA1 301 P04083 ANXA1 human Y21 447974 IENEEQEyVQtVkss X -ABL1 Abl P00519 human P38A 26416 P47811 Mapk14 mouse Y323 455799 DEPVADPyDQSFESR X X -ABL1 Abl P00519 human PXN 5829 P49023 PXN human Y118 448604 VGEEEHVysFPNkQk Paxillin X 2541; 69363 -ABL1 Abl P00519 human SMAD4 4089 Q13485 SMAD4 human Y195 1881244700 NRASTETyStPALLA X X -ABL1 Abl P00519 human ROBO1 6091 Q9Y6N7 ROBO1 human Y1038 13249800 MLPESTVyGDVDLSN X -ABL1 Abl P00519 human YB-1 22608 P62960 Ybx1 mouse Y70 3797338 WFNVRNGyGFINRND CSD X X -ABL1 Abl P00519 human CRKL 1399 P46109 CRKL human Y207 447954 IPEPAHAyAQPQttt X X 3181; 34940; 94358 -ABL1 Abl P00519 human VAV1 7409 P15498 VAV1 human Y174 447866 EAEGDEIyEDLMRsE X -ABL1 Abl P00519 human p63 8626 Q9H3D4 TP63 human Y290 10359106 RQSVLVPyEPPQVGT P53 X -ABL1 Abl P00519 human PIK3R1 282307 P23727 PIK3R1 cow Y368 448134 STKMHGDyTLTLRKG SH2 X -ABL1 Abl P00519 human vinexin 282843 NP_001005762 Sorbs3 rat Y127 466573 QHPDPAWyQTWPGPG X X -ABL1 Abl P00519 human DCBLD2 131566 Q96PD2 DCBLD2 human T756 1869653001 VyQVPQStQEVsGAG X -ABL1 Abl P00519 human Rb 5925 P06400 RB1 human Y805 456752 rIPGGNIyIsPLksP Rb_C X X -ABL1 Abl P00519 human NOX5 79400 Q96PH1 NOX5 human Y476 1869973807 FHYRPGDyLyLNIPT FAD_binding_8 X -ABL1 Abl P00519 human FHL2 2274 Q14192 FHL2 human Y176 23106943 ITTGGVtyREQPWHK LIM X -ABL1 Abl P00519 human MDM2 4193 Q00987 MDM2 human Y394 455777 QsQESEDysQPSTSS X X -ABL1 Abl P00519 human ER-alpha 2099 P03372 ESR1 human Y219 12620700 sIQGHNDyMCPATNQ zf-C4 X X -ABL1 Abl P00519 human BMPR1A 12166 P36895 Bmpr1a mouse Y453 3712679 TGGIVEEyQLPyyNM PK_Tyr_Ser-Thr X -ABL1 Abl P00519 human RAPGEF1 2889 Q13905 RAPGEF1 human Y504 448393 APIPSVPyAPFAAIL X X -ABL1 Abl P00519 human PLK1 5347 P53350 PLK1 human Y445 54066601 DSTRLILyNDGDsLQ POLO_box X X -ABL1 Abl P00519 human CRK 1398 P46108 CRK human Y239 450357 NLQNGPIyARVIQKR SH3_2 X X -ABL1 Abl P00519 human ZAP70 7535 P43403 ZAP70 human Y319 447587 tsVyEsPysDPEELk X 2701; 2717; 14791; 73382; 82975; 31754 -ABL1 Abl P00519 human JunB 3726 P17275 JUNB human Y182 41655504 GPEPPPVyTNLSSyS Jun X -ABL1 Abl P00519 human EGFR 1956 P00533 EGFR human Y1092 448057 tFLPVPEyINQsVPk X 2236; 2234; 3777; 14565; 8543; 48576 -ABL1 Abl P00519 human DCBLD2 131566 Q96PD2 DCBLD2 human S600 4149428 tPVRysssEVNHLsP X -ABL1 Abl P00519 human Abi-1 10006 Q8IZP0 ABI1 human Y213 449523 PPtVPNDyMtsPARL X X -ABL1 Abl P00519 human MAVS 57506 Q7Z434 MAVS human Y30 63080401 DVVEILPyLPCLTAR CARD_2 X -ABL1 Abl P00519 human PHF5A 84844 Q7RTV0 PHF5A human Y36 463988 kCVICDSyVRPCTLV PHF5 X X -ABL1 Abl P00519 human p63 8626 Q9H3D4 TP63 human Y149 452168 SVTAPSPyAQPSSTF X 4665 -ABL1 Abl P00519 human Abl iso2 25 P00519-2 ABL1 human Y412 450298 RLMTGDtyTAHAGAK PK_Tyr_Ser-Thr X 2865 -ABL1 Abl P00519 human DCBLD1 285761 Q8N8Z6 DCBLD1 human S697 1869653010 PGTsDsysAPRDCLT X -ABL1 Abl P00519 human PXN 5829 P49023 PXN human Y31 448785 FLSEEtPysyPtGNH X -ABL1 Abl P00519 human WASF3 10810 Q9UPY6 WASF3 human Y151 486448 KKDGLKFyTDPSyFF X -ABL1 Abl P00519 human DCBLD1 285761 Q8N8Z6 DCBLD1 human Y665 38483937 AQPADRGyDRPKAVs X -ABL1 Abl P00519 human PDGFRB 5159 P09619 PDGFRB human Y686 7437801 IITEyCRyGDLVDyL PK_Tyr_Ser-Thr X -ABL1 Abl P00519 human DCBLD2 131566 Q96PD2 DCBLD2 human S598 4033223 EEtPVRysssEVNHL X -ABL1 Abl P00519 human CDC73 79577 Q6P1J9 CDC73 human Y293 20831311 IPAAyNRyDQERFkG CDC73_N X -ABL1 Abl P00519 human CASP9 842 P55211 CASP9 human Y397 286046008 AVSVkGIyKQMPGCF Peptidase_C14 X X -ABL1 Abl P00519 human PYCARD 29108 Q9ULZ3 PYCARD human Y146 465096 kVLTDEQyQAVRAEP CARD X -ABL1 Abl P00519 human CD19 930 P15391 CD19 human Y508 459617 EDMRGILyAAPQLRs X -ABL1 Abl P00519 human p27Kip1 1027 P46527 CDKN1B human Y88 456818 kGsLPEFyyRPPRPP X X -ABL1 Abl P00519 human CTNNB1 1499 P35222 CTNNB1 human Y86 447584 VADIDGQyAMTRAQR X X -ABL1 Abl P00519 human FOXA1 3169 P55317 FOXA1 human Y429 60189900 QALQYsPyGSTLPAS HNF_C X -ABL1 Abl P00519 human smMLCK 4638 Q15746 MYLK human Y792 15712003 QPWHAGQyEILLKNR I-set X -ABL1 Abl P00519 human smMLCK 4638 Q15746 MYLK human Y464 451414 QEGsIEVyEDAGsHy I-set X X -ABL1 Abl P00519 human DCBLD2 131566 Q96PD2 DCBLD2 human Y655 478857 GyADLDPyNsPGQEV X -ABL1 Abl P00519 human JunB 3726 P17275 JUNB human Y173 41655503 PAGPGGVyAGPEPPP Jun X -ABL1 Abl P00519 human SNCA 6622 P37840 SNCA human Y125 448279 VDPDNEAyEMPsEEG Synuclein X -ABL1 Abl P00519 human NOX5 79400 Q96PH1 NOX5 human Y478 1869973808 YRPGDyLyLNIPTIA FAD_binding_8 X -ABL1 Abl P00519 human smMLCK 4638 Q15746 MYLK human Y231 15712000 NQDDVGVyTCLVVNG I-set X -ABL1 Abl P00519 human smMLCK 4638 Q15746 MYLK human Y846 15712001 DGGGSDRyGsLRPGW X -ABL1 Abl P00519 human BCAP 118788 Q6ZUJ8 PIK3AP1 human Y594 459548 DRPQssIyDPFAGMk X -ABL1 Abl P00519 human GPX1 2876 P07203 GPX1 human Y98 455673 EILNSLkyVRPGGGF GSHPx X X -ABL1 Abl P00519 human SNIP 80725 Q9C0H9 SRCIN1 human Y396 456704 LVKGEGLyADPyGLL X X -ABL1 Abl P00519 human eNOS 4846 P29474 NOS3 human Y81 456466 WEVGSITyDTLSAQA X -ABL1 Abl P00519 human DCBLD2 131566 Q96PD2 DCBLD2 human S760 51390534 PQStQEVsGAGRDGE X -ABL1 Abl P00519 human MDM4 4194 O15151 MDM4 human Y99 6039500 VkDPsPLyDMLRKNL X -ABL1 Abl P00519 human HIPK2 28996 Q9H2X6 HIPK2 human Y367 1033356 tyLQsRYyRAPEIIL Pkinase X -ABL1 Abl P00519 human TIF1G 51592 Q9UPN9 TRIM33 human Y1048 15406627 MMKVVQVyADtQEIN Bromodomain X -ABL1 Abl P00519 human TBX21 30009 Q9UL17 TBX21 human Y220 20583307 SMPGNRLyVHPDSPN T-box X X -ABL1 Abl P00519 human PSMA7 5688 O14818 PSMA7 human Y106 15570108 EDPVTVEyItRyIAS Proteasome X -ABL1 Abl P00519 human PPAR-gamma 5468 P37231 PPARG human Y78 36692605 SSISTPHyEDIPFTR PPARgamma_N X -ABL1 Abl P00519 human ATR 545 Q13535 ATR human Y291 15434301 DTDQLKLyEEPLSkL X X -ABL1 Abl P00519 human SHP-2 19247 P35235 Ptpn11 mouse Y542 448492 sKRKGHEytNIKYSL X 3751; 94740; 15543; 64117 -ABL1 Abl P00519 human DCBLD2 131566 Q96PD2 DCBLD2 human Y649 473121 EEGKEAGyADLDPyN X -ABL1 Abl P00519 human AHSA1 10598 O95433 AHSA1 human Y223 3914778 LtsPEELyRVFTTQE AHSA1 X X -ABL1 Abl P00519 human DCBLD1 285761 Q8N8Z6 DCBLD1 human Y589 3782797 QRAGRHEyALPLAPP X -ABL1 Abl P00519 human PKCD 170538 P09215 Prkcd rat Y155 447575 IKQAKIHyIKNHEFI X -ABL1 Abl P00519 human DRP1 10059 O00429 DNM1L human Y266 297110000 TDSIRDEyAFLQkkY Dynamin_M X X -ABL1 Abl P00519 human SORBS1 iso5 20411 Q62417-5 Sorbs1 mouse Y632 11498500 LCSYQALySYVPQND SH3_9 X -ABL1 Abl P00519 human galectin-3 3958 P17931 LGALS3 human Y107 14823408 AYPATGPyGAPAGPL X X -ABL1 Abl P00519 human galectin-3 3958 P17931 LGALS3 human Y79 13213701 GAPAPGVyPGPPSGP X X -ABL1 Abl P00519 human BMPR1A 12166 P36895 Bmpr1a mouse Y457 25655000 VEEyQLPyyNMVPSD PK_Tyr_Ser-Thr X -ABL1 Abl P00519 human DCBLD1 285761 Q8N8Z6 DCBLD1 human Y600 3479143 LAPPEPEyAtPIVER X -ABL1 Abl P00519 human WASF3 10810 Q9UPY6 WASF3 human Y486 486451 SRRIAVEySDSDDDS X -ABL1 Abl P00519 human DCBLD1 285761 Q8N8Z6 DCBLD1 human S556 11098235 GTVTRKGsTFRPMDT X -ABL1 Abl P00519 human ER-beta 2100 Q92731 ESR2 human Y36 34425602 SIYIPSSyVDSHHEY ERbeta_N X -ABL1 Abl P00519 human RAD51 5888 Q06609 RAD51 human Y54 449958 HTVEAVAyAPkkELI HHH_5 X X -ABL1 Abl P00519 human EGFR 1956 P00533 EGFR human Y1197 448060 stAENAEyLRVAPQS X 2244; 4407; 47737 -ABL1 Abl P00519 human GLO1 2739 Q04760 GLO1 human Y136 463450 GIAVPDVysACkRFE Glyoxalase X -ABL1 Abl P00519 human STX17 55014 P56962 STX17 human Y157 479165 SQSLTQIyALPEIPQ X -ABL1 Abl P00519 human PPAR-gamma 5468 P37231 PPARG human Y102 9256871 yDLKLQEyQSAIkVE PPARgamma_N X -ABL1 Abl P00519 human Geminin 51053 O75496 GMNN human Y150 33402208 EVAEHVQyMAELIER Geminin X X -ABL1 Abl P00519 human SNCA 6622 P37840 SNCA human Y39 3546424 kTkEGVLyVGsKTkE Synuclein X X -ABL1 Abl P00519 human N-WASP Q95107 WASL cow Y256 450253 RETSKVIyDFIEKTG PBD X X -ABL1 Abl P00519 human IkB-alpha 4792 P25963 NFKBIA human Y305 448799 FtEDELPyDDCVFGG X -ABL1 Abl P00519 human MUC1 4582 P15941 MUC1 human Y1243 454879 NGGSsLsytNPAVAA X -ABL1 Abl P00519 human DCBLD1 285761 Q8N8Z6 DCBLD1 human S693 1869653005 PPTHPGTsDsysAPR X -ABL1 Abl P00519 human ArgBP2 iso2 8470 O94875-2 SORBS2 human Y573 11057708 NTKGAEDyPDPPIPH X -ABL1 Abl P00519 human NET1 56349 Q9Z206 Net1 mouse Y424 1881982102 TRNERHLyQVyRQPI X -ABL1 Abl P00519 human MIG-6 54206 Q9UJM3 ERRFI1 human Y394 451607 KKVsstHyyLLPERP X -ABL1 Abl P00519 human caveolin-1 857 Q03135 CAV1 human Y14 448422 VDsEGHLytVPIREQ X 3251 -ABL1 Abl P00519 human RAD51 5888 Q06609 RAD51 human Y315 448324 EtRICKIyDSPCLPE Rad51 X -ABL1 Abl P00519 human FOXA1 3169 P55317 FOXA1 human Y464 60189901 PAYYQGVySRPVLNT X -ABL1 Abl P00519 human RTCB 51493 Q9Y3I0 RTCB human Y316 1876333508 GMAAAGNyAWVNRSS RtcB X X -ABL1 Abl P00519 human ER-alpha 2099 P03372 ESR1 human Y52 12620701 DssKPAVyNYPEGAA Oest_recep X X -ABL1 Abl P00519 human ATR 545 Q13535 ATR human Y310 15434300 FPFEAEAyRNIEPVY X X -ABL1 Abl P00519 human DAB1 13131 P97318 Dab1 mouse Y220 447630 PETEENIyQVPTSQK X 3327 -ABL1 Abl P00519 human Bcr 613 P11274 BCR human Y177 447792 ADAEKPFyVNVEFHH X X 3901 -ABL1 Abl P00519 human PLCG1 5335 P19174 PLCG1 human Y1003 3954534 KGKKFLQyNRLQLSR PI-PLC-Y X -ABL1 Abl P00519 human Met 4233 P08581 MET human Y1356 448473 yVHVNAtyVNVKCVA X -ABL1 Abl P00519 human BMPR1A 12166 P36895 Bmpr1a mouse Y467 25655001 MVPSDPSyEDMREVV PK_Tyr_Ser-Thr X -ABL1 Abl P00519 human Btk 695 Q06187 BTK human Y223 447485 LKKVVALyDyMPMNA SH3_1 X 5082; 87141; 87457 -ABL1 Abl P00519 human Catalase 12359 P24270 Cat mouse Y231 450444 NADGEAVyCkFHYkT Catalase X -ABL1 Abl P00519 human EGFR 1956 P00533 EGFR human Y1016 448055 DVVDADEyLIPQQGF X 2235 -ABL1 Abl P00519 human RACK1 10399 P63244 RACK1 human Y52 464119 LtrDEtNyGIPQRAL X X -ABL1 Abl P00519 human ArgBP2 iso2 8470 O94875-2 SORBS2 human Y175 7783536 YTYNAGLyNPPYSAQ X -ABL1 Abl P00519 human Arg 27 P42684 ABL2 human Y261 455657 GLVTTLHyPAPKCNK X X -ABL1 Abl P00519 human MST2 6788 Q13188 STK3 human Y81 25528501 MQQCDSPyVVKYYGS Pkinase X X -ABL1 Abl P00519 human PLCG1 5335 P19174 PLCG1 human Y771 448575 IGtAEPdyGALyEGR X X -ABL1 Abl P00519 human PLK1 5347 P53350 PLK1 human Y217 464048 tLCGtPNyIAPEVLs Pkinase X X -ABL1 Abl P00519 human Skip 22938 Q13573 SNW1 human Y292 464278 AKLAEALyIADRKAR SKIP_SNW X -ABL1 Abl P00519 human BCAP 118788 Q6ZUJ8 PIK3AP1 human Y570 450912 QERPGNFyVSSEsIR X -ABL1 Abl P00519 human C/EBP-beta 1051 P17676 CEBPB human Y78 9397201 RAIDFsPyLEPLGAP X -ABL1 Abl P00519 human DCBLD1 285761 Q8N8Z6 DCBLD1 human Y540 1869653009 ITsDMADyQQPLMIG X -ABL1 Abl P00519 human FAM105B 90268 Q96BN8 OTULIN human Y56 3560103 AEHEEDMyRAADEIE X X -ABL1 Abl P00519 human Jun 3725 P05412 JUN human Y170 447687 LHSEPPVyANLSNFN Jun X -ABL1 Abl P00519 human IRF3 3661 Q14653 IRF3 human Y292 1867930600 rLGHCHTyWAVSEEL IRF-3 X -ABL1 Abl P00519 human DCBLD2 131566 Q96PD2 DCBLD2 human Y597 4033219 HEEtPVRysssEVNH X -ABL1 Abl P00519 human CRK 417553 Q04929 CRK chicken Y222 447951 GGPEPGPyAQPSINT X X -ABL1 Abl P00519 human DCBLD2 131566 Q96PD2 DCBLD2 human Y621 454599 LQADsAEyAQPLVGG X -ABL1 Abl P00519 human Cortactin 2017 Q14247 CTTN human Y486 447704 yPAEDStyDEYENDL X -ABL1 Abl P00519 human p63 8626 Q9H3D4 TP63 human Y171 10359107 AIPSNTDyPGPHSFD P53 X -ABL1 Abl P00519 human SRC-3 8202 Q9Y6Q9 NCOA3 human Y1357 4668109 HPQAASIyQSSEMKG X X -ABL1 Abl P00519 human RNPC2 9584 Q14498 RBM39 human Y95 3196190 DRRFRGRyrsPysGP X -ABL1 Abl P00519 human Skip 22938 Q13573 SNW1 human Y433 459533 EDEIyNVyDQAWrGG X -ABL1 Abl P00519 human emerin 2010 P50402 EMD human Y167 449653 AyQsItHyRPVsAsR X -ABL1 Abl P00519 human DCBLD2 131566 Q96PD2 DCBLD2 human T679 1869653002 ITGPEyAtPIIMDMS X -ABL1 Abl P00519 human NCK1 4690 P16333 NCK1 human Y105 448953 VDPGERLyDLNMPAy X X -ABL1 Abl P00519 human BCAP 118788 Q6ZUJ8 PIK3AP1 human Y694 450993 AKVEFGVyEsGPRKs X -ABL1 Abl P00519 human CRK 12928 Q64010 Crk mouse Y221 447951 GGPEPGPyAQPsVNt X 3491 -ABL1 Abl P00519 human PSD-95 29495 P31016 Dlg4 rat Y533 473111 VTQMEVHyARPIIIL Guanylate_kin X -ABL1 Abl P00519 human DCBLD2 131566 Q96PD2 DCBLD2 human Y677 475112 LPITGPEyAtPIIMD X -ABL1 Abl P00519 human Catalase 847 P04040 CAT human Y386 450445 yRARVANyQRDGPMC Catalase X X -ABL1 Abl P00519 human p21Cip1 12575 P39689 Cdkn1a mouse Y76 26400605 SLGLPKVyLsPGSRS X -ABL1 Abl P00519 human RAD52 5893 P43351 RAD52 human Y104 449061 DLNNGKFyVGVCAFV Rad52_Rad22 X -ABL1 Abl P00519 human ROBO1 6091 Q9Y6N7 ROBO1 human Y1114 465166 QEVAPVQyNIVEQNk X -ABL1 Abl P00519 human YAP1 iso3 10413 P46937-3 YAP1 human Y357 473004 SGLSMSSySVPRtPD X -ABL1 Abl P00519 human WASF3 10810 Q9UPY6 WASF3 human Y337 486450 LPAQIIEyYNPSGPP X -ABL1 Abl P00519 human SORBS1 iso5 20411 Q62417-5 Sorbs1 mouse Y326 460519 RAEPKSIyEYQPGKS X -ABL1 Abl P00519 human DDX5 1655 P17844 DDX5 human Y593 470084 NGMNQQAyAyPATAA X X -ABL1 Abl P00519 human DCBLD1 285761 Q8N8Z6 DCBLD1 human S513 4775486 yPFARHQsAEFtISY X -ABL1 Abl P00519 human PLK1 5347 P53350 PLK1 human Y425 62370600 SDkYGLGyQLCDNSV POLO_box X X -ABL1 Abl P00519 human DCBLD2 131566 Q96PD2 DCBLD2 human S618 23097815 TTVLQADsAEyAQPL X -ABL1 Abl P00519 human CDC73 79577 Q6P1J9 CDC73 human Y290 3449102 kQPIPAAyNRyDQER CDC73_N X -ABL1 Abl P00519 human RhoGDI beta 397 P52566 ARHGDIB human Y24 448978 ELdskLNykPPPQks Rho_GDI X X -ABL1 Abl P00519 human TBX21 30009 Q9UL17 TBX21 human Y266 20583306 VLQsLHKyQPRLHIV T-box X X -ABL1 Abl P00519 human smMLCK 4638 Q15746 MYLK human Y1635 15712005 VAPEVINyEPIGYAT Pkinase X -ABL1 Abl P00519 human JunB 3726 P17275 JUNB human Y188 41655505 VyTNLSSySPASASS Jun X -ABL1 Abl P00519 human DCBLD2 131566 Q96PD2 DCBLD2 human Y666 478858 GQEVyHAyAEPLPIT X -ABL1 Abl P00519 human Abi-1 11308 Q8CBW3 Abi1 mouse Y428 3589548 IEKVVAIyDYTKDKD SH3_1 X -ABL1 Abl P00519 human BCAP 118788 Q6ZUJ8 PIK3AP1 human Y553 13203803 QLPDNEPyIFKVFAE X -ABL1 Abl P00519 human GMF-gamma 9535 O60234 GMFG human Y104 33670301 kPEQQMMyAGSkNRL Cofilin_ADF X X -ABL1 Abl P00519 human SNIP 80725 Q9C0H9 SRCIN1 human Y264 456703 IYRKEPLyAAFPGSH AIP3 X X -ABL1 Abl P00519 human PSMA7 5688 O14818 PSMA7 human Y153 456317 QTDPsGtyHAWkANA Proteasome X X -ABL1 Abl P00519 human TIF1G 51592 Q9UPN9 TRIM33 human Y524 15416086 QHMQQQVyAQKHQQL X -ABL1 Abl P00519 human p27Kip1 1027 P46527 CDKN1B human Y89 456819 GsLPEFyyRPPRPPK X -ABL1 Abl P00519 human NuMA-1 4926 Q14980 NUMA1 human Y1774 449717 VEsLEsLyFtPIPAR X X -ABL1 Abl P00519 human P38A 26416 P47811 Mapk14 mouse Y182 447971 tDDEMtGyVAtRWYR Pkinase X X 9211; 9215; 4551; 9216; 4552; 4631; 4511; 4092; 9219; 24678; 8632; 6908; 41768; 51255; 14594; 14598; 62979 -ABL1 Abl P00519 human DCBLD1 285761 Q8N8Z6 DCBLD1 human Y578 3470366 STDAGGHyDCPQRAG X -ABL1 Abl P00519 human CRK 1398 P46108 CRK human Y251 456549 QKRVPNAyDktALAL SH3_2 X X -ABL1 Abl P00519 human DRP1 10059 O00429 DNM1L human Y368 15569023 CGGARICyIFHETFG Dynamin_M X X -ABL1 Abl P00519 human PARIS 155061 Q6NUN9 ZNF746 human Y137 13831906 ETLVSLDyAISKPEV X X -ABL1 Abl P00519 human DCBLD2 131566 Q96PD2 DCBLD2 human T593 27447065 kAVDHEEtPVRysss X -ABL1 Abl P00519 human TUBG1 7283 P23258 TUBG1 human Y443 1876567500 HAATRPDyISWGTQE X -ABL1 Abl P00519 human PLEKHG2 64857 Q9H7P9 PLEKHG2 human Y489 23133014 sEPVKDPyVMFPQNA X -ABL1 Abl P00519 human DDB1 1642 Q16531 DDB1 human Y182 62873405 APTICFVyQDPQGRH MMS1_N X -ABL1 Abl P00519 human ArgBP2 iso2 8470 O94875-2 SORBS2 human Y50 31834902 AVSPMSYyQRPFSPS X -ABL1 Abl P00519 human galectin-3 3958 P17931 LGALS3 human Y118 13213700 AGPLIVPyNLPLPGG Gal-bind_lectin X X -ABL1 Abl P00519 human N-WASP Q95107 WASL cow Y175 458041 EITTNRFyGPQINNI X X -ABL1 Abl P00519 human SGK223 157285 Q86YV5 PRAG1 human Y413 449701 ATQPEPIyAEsTKRK X -ABL1 Abl P00519 human smMLCK 4638 Q15746 MYLK human Y611 462699 KSSRkSEyLLPVAPS X -ABL1 Abl P00519 human CTNNB1 1499 P35222 CTNNB1 human Y489 462002 QNAVRLHyGLPVVVk X -ABL1 Abl P00519 human CTNNB1 1499 P35222 CTNNB1 human Y654 447585 RNEGVAtyAAAVLFR X X -ABL1 Abl P00519 human ArgBP2 iso2 8470 O94875-2 SORBS2 human Y164 23083166 PDDDTDMyNTPYTYN X -ABL1 Abl P00519 human DRP1 10059 O00429 DNM1L human Y449 297110001 IIQHCSNySTQELLR Dynamin_M X X -ABL1 Abl P00519 human SHP-2 19247 P35235 Ptpn11 mouse Y63 455054 IQNTGDyyDLyGGEK SH2 X -ABL1 Abl P00519 human PLSCR1 5359 O15162 PLSCR1 human Y74 464050 PVyNQPVyNQPVGAA X -ABL1 Abl P00519 human ERCC6 2074 Q03468 ERCC6 human Y932 486324 GANRVVIyDPDWNPS Helicase_C X -ABL1 Abl P00519 human JAK2 16452 Q62120 Jak2 mouse Y1007 448407 VLPQDKEyyKVKEPG PK_Tyr_Ser-Thr X 3771; 3776; 4406; 66245; 32901 -ABL1 Abl P00519 human DCBLD2 131566 Q96PD2 DCBLD2 human T714 15409263 QPPPLVGtyNtLLsR X -ABL1 Abl P00519 human PARK2 5071 O60260 PRKN human Y143 15624700 sPAGRSIyNSFYVYC X X -ABL1 Abl P00519 human TAZ 97064 Q9EPK5 Wwtr1 mouse Y316 27138200 sGLGLGCySVPTTPE X X -ABL1 Abl P00519 human smMLCK 4638 Q15746 MYLK human Y556 15712002 LNGQPIQyARSTCEA I-set X -ABL1 Abl P00519 human Skip 22938 Q13573 SNW1 human Y430 459532 AGGEDEIyNVyDQAW X -ABL1 Abl P00519 human FHL2 2274 Q14192 FHL2 human Y97 473390 TDCySNEySSkCQEC LIM X -ABL1 Abl P00519 human RAD9A 5883 Q99638 RAD9A human Y28 447825 SRIGDELyLEPLEDG Rad9 X X -ABL1 Abl P00519 human SPTLC1 10558 O15269 SPTLC1 human Y164 27930808 KTEEAIIySYGFATI Aminotran_1_2 X X -ABL1 Abl P00519 human MAVS 57506 Q7Z434 MAVS human Y71 63080400 RRPGWVEyFIAALRG CARD_2 X -ABL1 Abl P00519 human CHCHD2 51142 Q9Y6H1 CHCHD2 human Y99 62463400 PARPDITyQEPQGTQ X -ABL1 Abl P00519 human MST1 6789 Q13043 STK4 human Y433 463558 kIPQDGDyEFLksWt Mst1_SARAH X X -ABL1 Abl P00519 human PDGFRB 5159 P09619 PDGFRB human Y934 447518 AHAsDEIyEIMQKCW PK_Tyr_Ser-Thr X -ABL1 Abl P00519 human RNPC2 9584 Q14498 RBM39 human Y99 12244420 RGRyrsPysGPkFNs X -ABL1 Abl P00519 human NFAT5 10725 O94916 NFAT5 human Y143 12127405 PkRHtVLyIsPPPED X -ABL1 Abl P00519 human DCBLD2 131566 Q96PD2 DCBLD2 human Y663 3974132 NsPGQEVyHAyAEPL X -ABL1 Abl P00519 human MIG-6 54206 Q9UJM3 ERRFI1 human Y395 454989 KVsstHyyLLPERPP X -ABL1 Abl P00519 human TIF1G 51592 Q9UPN9 TRIM33 human Y610 25756330 PrHSGPQySMMQPHL X -ABL1 Abl P00519 human WASF3 10810 Q9UPY6 WASF3 human Y248 486449 HASDVtDySYPATPN X -ABL1 Abl P00519 human HDAC2 3066 Q92769 HDAC2 human Y222 464957 IGAGkGkyYAVNFPM Hist_deacetyl X -ABL1 Abl P00519 human FHL2 2274 Q14192 FHL2 human Y236 25292373 SGLGGTkyIsFEERQ LIM X -ABL1 Abl P00519 human SORBS1 iso5 20411 Q62417-5 Sorbs1 mouse Y360 3782802 SEPPGYIySSNFHAV X -ABL1 Abl P00519 human YB-1 22608 P62960 Ybx1 mouse Y97 15416754 kkNNPRKyLRsVGDG CSD X X -ABL1 Abl P00519 human ROBO1 6091 Q9Y6N7 ROBO1 human Y1073 465118 PSGQPTPyAtTQLIQ X X -ABL1 Abl P00519 human smMLCK 4638 Q15746 MYLK human Y1575 15712004 QISEGVEyIHKQGIV Pkinase X -ABL1 Abl P00519 human PDHA1 5160 P08559 PDHA1 human Y301 454753 MsDPGVsyRtREEIQ E1_dh X -ABL1 Abl P00519 human MyoD 17927 P10085 Myod1 mouse Y30 449872 FETADDFyDDPCFDs Basic X X -ABL1 Abl P00519 human MyoD 17927 P10085 Myod1 mouse Y212 449871 CSDGMMDySGPPSGP Myf5 X X -ABL1 Abl P00519 human MDM2 4193 Q00987 MDM2 human Y276 465467 sDEDDEVyQVtVyQA X X -ABL1 Abl P00519 human RTCB 51493 Q9Y3I0 RTCB human Y306 55380503 AsPEGQDyLkGMAAA RtcB X X -ABL1 Abl P00519 human PDHK1 5163 Q15118 PDK1 human Y243 462384 ARRLCDLyyINSPEL X -ABL1 Abl P00519 human hnRNP P2 2521 P35637 FUS human Y526 50318713 QDrrErPy_______ X -ABL1 Abl P00519 human FHL2 2274 Q14192 FHL2 human Y217 1873117006 LNCFCDLyAKkCAGC LIM X -ABL1 Abl P00519 human DCBLD2 131566 Q96PD2 DCBLD2 human S599 477979 EtPVRysssEVNHLs X -ABL1 Abl P00519 human NET1 56349 Q9Z206 Net1 mouse Y427 1881982104 ERHLyQVyRQPIPVQ X -ABL1 Abl P00519 human MDM2 4193 Q00987 MDM2 human Y405 465468 STSSSIIyssQEDVK X -ABL1 Abl P00519 human DCBLD1 285761 Q8N8Z6 DCBLD1 human Y621 3476708 tFsAQsGyRVPGPQP X -ABL1 Abl P00519 human DCBLD1 285761 Q8N8Z6 DCBLD1 human Y696 482942 HPGTsDsysAPRDCL X -ABL1 Abl P00519 human Lasp-1 3927 Q14847 LASP1 human Y171 451675 IPtsAPVyQQPQQQP X X -ABL1 Abl P00519 human PRKD1 5587 Q15139 PRKD1 human Y463 448648 NDTGsRYyKEIPLSE PH X X -ABL1 Abl P00519 human YY1 7528 P25490 YY1 human Y254 464367 sPPDySEyMTGkKLP X X -ABL1 Abl P00519 human RhoGDI beta 397 P52566 ARHGDIB human Y130 4113623 LkYVQHtyRTGVkVD Rho_GDI X X -ABL1 Abl P00519 human DDB1 1642 Q16531 DDB1 human Y718 1243008 HIRtVPLyEsPRkIC X -ABL1 Abl P00519 human WASP 7454 P42768 WAS human Y291 447985 AEtsKLIyDFIEDQG PBD X -ABL1 Abl P00519 human CKMT1A 548596 P12532 CKMT1B human Y153 475235 AsKIRsGyFDErYVL X X -ABL1 Abl P00519 human DCBLD1 285761 Q8N8Z6 DCBLD1 human S535 1869653012 QkLDLITsDMADyQQ X -ABL1 Abl P00519 human Tip60 10524 Q92993 KAT5 human Y44 28132103 ISGRKLFyVHYIDFN Tudor-knot X -ABL1 Abl P00519 human WAVE2 242687 Q8BH43 Wasf2 mouse Y150 455197 GKEALKFyTNPSyFF X -ABL1 Abl P00519 human MAVS 57506 Q7Z434 MAVS human Y9 25687502 PFAEDkTykyICRNF CARD_2 X -ABL1 Abl P00519 human SHP-2 19247 P35235 Ptpn11 mouse Y580 448493 REDsARVyENVGLMQ X X 3703; 5431; 13328 -ABL1 Abl P00519 human RTCB 51493 Q9Y3I0 RTCB human Y475 1876333510 MEEAPESykNVTDVV RtcB X X -ABL1 Abl P00519 human DCBLD1 285761 Q8N8Z6 DCBLD1 human Y652 2424923 VGAQDGDyQRPHsAQ X -ABL1 Abl P00519 human TOP1 7150 P11387 TOP1 human Y268 454026 AkMLDHEyTTkEIFR Topoisom_I_N X -ABL1 Abl P00519 human NFAT5 D3ZGB1 Nfat5 rat Y160 12127405 PKRHTVLyISPPPED X X -ABL1 Abl P00519 human SMAD4 4089 Q13485 SMAD4 human Y322 1881244704 SNHPAPEyWCSIAYF X -ABL1 Abl P00519 human VAV1 7409 P15498 VAV1 human Y267 460537 TPGAANLyQVFIKYK RhoGEF X -Mtor mTOR P42346 rat IRS1 25467 P35570 Irs1 rat S423 17550915 sDGGFIssDEYGSSP X X -Mtor mTOR P42346 rat 4E-BP1 13685 Q60876 Eif4ebp1 mouse T45 447496 GGtLFsttPGGtRII eIF_4EBP X 2855; 9459; 2846; 4923; 5123; 3929; 7547; 45613; 39788 -Mtor mTOR P42346 rat 4E-BP1 116636 Q62622 Eif4ebp1 rat S64 447527 FLMECRNsPVAKtPP eIF_4EBP X 9451; 9456 -Mtor mTOR P42346 rat IRS1 25467 P35570 Irs1 rat S422 40511593 PsDGGFIssDEYGSS X X -Mtor mTOR P42346 rat 4E-BP1 13685 Q60876 Eif4ebp1 mouse T36 447497 PPGDysttPGGtLFs eIF_4EBP X 2855; 9459; 2846; 4923; 5123; 3929; 7547; 45613; 39788 -Mtor mTOR P42346 rat 4E-BP1 116636 Q62622 Eif4ebp1 rat T45 447496 GGtLFSttPGGtRII eIF_4EBP X 2855; 9459; 2846; 5123; 3929; 7547; 45613; 39788 -Mtor mTOR P42346 rat 4E-BP1 116636 Q62622 Eif4ebp1 rat T36 447497 PPGDYsttPGGtLFS eIF_4EBP X 2855; 9459; 2846; 5123; 3929; 7547; 45613; 39788 -Mtor mTOR P42346 rat 4E-BP1 1978 Q13541 EIF4EBP1 human T37 447497 PPGDysttPGGtLFs eIF_4EBP X 2855; 9459; 2846; 5123; 3929; 7547; 45613; 39788 -Mtor mTOR P42346 rat 4E-BP1 1978 Q13541 EIF4EBP1 human T46 447496 GGtLFsttPGGtRII eIF_4EBP X 2855; 9459; 2846; 4923; 5123; 3929; 7547; 45613; 39788 -Mtor mTOR P42346 rat 4E-BP1 116636 Q62622 Eif4ebp1 rat S82 447525 PTIPGVTsPTSDEPP eIF_4EBP X -Mtor mTOR P42346 rat 4E-BP1 116636 Q62622 Eif4ebp1 rat T69 447528 RNsPVAKtPPKDLPT eIF_4EBP X 9455 -CDC7 CDC7 O00311 human NCL 4691 P19338 NCL human T121 470366 PGkALVAtPGkkGAA X -CDC7 CDC7 O00311 human claspin 63967 Q9HAW4 CLSPN human S1129 36898303 LADGDLHsDGPGRMR X -CDC7 CDC7 O00311 human DTD1 92675 Q8TEA8 DTD1 human S194 3072143 tPRKEDRsAssGAEG X -CDC7 CDC7 O00311 human TOP2A 7153 P11388 TOP2A human S1525 448764 PIKyLEEsDEDDLF_ X X -CDC7 CDC7 O00311 human DBF4 10926 Q9UBU7 DBF4 human S312 30988261 DLETHLLsEQHRNFA zf-DBF X -CDC7 CDC7 O00311 human CDC7 8317 O00311 CDC7 human S216 56757904 ELLkFVQsEAQQERC Pkinase X -CDC7 CDC7 O00311 human MCM2 4171 P49736 MCM2 human S41 452312 RtDALtssPGRDLPP X -CDC7 CDC7 O00311 human claspin 63967 Q9HAW4 CLSPN human S260 31088186 SLESGVHsFEEGsEL X -CDC7 CDC7 O00311 human DBF4 10926 Q9UBU7 DBF4 human T281 18909809 DGDKyGGtsIQLQLK X -CDC7 CDC7 O00311 human claspin 63967 Q9HAW4 CLSPN human S110 4748776 IYkTVADsDESYMEK X -CDC7 CDC7 O00311 human DTD1 92675 Q8TEA8 DTD1 human S196 476434 RKEDRsAssGAEGDV X -CDC7 CDC7 O00311 human claspin 63967 Q9HAW4 CLSPN human S1147 3685672 WKNIDDAsQMDLFHR X -CDC7 CDC7 O00311 human DTD1 92675 Q8TEA8 DTD1 human T187 36396302 EssKERNtPRKEDRs X -CDC7 CDC7 O00311 human CDC7 8317 O00311 CDC7 human S277 36123859 GKDGkEGsVGLSVQR X -CDC7 CDC7 O00311 human CDC7 8317 O00311 CDC7 human S296 31859383 ERNFNIHssISHEsP X -CDC7 CDC7 O00311 human MCM2 4171 P49736 MCM2 human S40 452311 RRtDALtssPGRDLP X X -CDC7 CDC7 O00311 human DTD1 92675 Q8TEA8 DTD1 human S181 36396300 RAKGPsEssKERNtP X -CDC7 CDC7 O00311 human DTD1 92675 Q8TEA8 DTD1 human S197 1983955 KEDRsAssGAEGDVs X -CDC7 CDC7 O00311 human NPM1 4869 P06748 NPM1 human T199 448515 VkKsIrDtPAkNAQK X 3541; 75984 -CDC7 CDC7 O00311 human MCM2 4171 P49736 MCM2 human S220 2201403 NVFkERIsDMCkENR MCM_N X -CDC7 CDC7 O00311 human claspin 63967 Q9HAW4 CLSPN human S721 4748805 sVPKsLssDstLLLF X -CDC7 CDC7 O00311 human DTD1 92675 Q8TEA8 DTD1 human S179 23112003 KTRAKGPsEssKERN X -CDC7 CDC7 O00311 human MCM2 4171 P49736 MCM2 human S31 2201404 LtssPGRssRRtDAL X -CDC7 CDC7 O00311 human MCM2 4171 P49736 MCM2 human S7 2201406 _MAEssEsFtMAssP X -CDC7 CDC7 O00311 human MFAP1 4236 P55081 MFAP1 human S116 452340 EPEVVGEsDsEVEGD X -CDC7 CDC7 O00311 human MCM2 4171 P49736 MCM2 human S5 2201405 ___MAEssEsFtMAs X X -CDC7 CDC7 O00311 human CDC7 8317 O00311 CDC7 human S318 56757903 SkTVDVLsRKLATKK X -CDC7 CDC7 O00311 human claspin 63967 Q9HAW4 CLSPN human S67 3212958 kVLQDsDsETEDTNA X -CDC7 CDC7 O00311 human DTD1 92675 Q8TEA8 DTD1 human S204 476435 sGAEGDVssErEP__ X -CDC7 CDC7 O00311 human AurB 9212 Q96GD4 AURKB human T236 4164705 RRktMCGtLDyLPPE Pkinase X -CDC7 CDC7 O00311 human CDC7 8317 O00311 CDC7 human S239 27445979 TGNkIPLsGPVPkEL X -CDC7 CDC7 O00311 human NCL 4691 P19338 NCL human T76 483581 tkkVAVAtPAkkAAV X -CDC7 CDC7 O00311 human CDC7 8317 O00311 CDC7 human S285 56757902 VGLSVQRsVFGERNF X -CDC7 CDC7 O00311 human CDC7 8317 O00311 CDC7 human S297 31859386 RNFNIHssISHEsPA X -CDC7 CDC7 O00311 human MCM2 4171 P49736 MCM2 human S4 2201407 ____MAEssEsFtMA X -CDC7 CDC7 O00311 human claspin 63967 Q9HAW4 CLSPN human S704 12200600 KENNDGssEIGkAVG X -CDC7 CDC7 O00311 human MCM2 4171 P49736 MCM2 human S108 456310 DVEELtAsQREAAER MCM2_N X X -CDC7 CDC7 O00311 human NPM1 4869 P06748 NPM1 human S137 476036 EEDVkLLsIsGkRsA X -CDC7 CDC7 O00311 human DTD1 92675 Q8TEA8 DTD1 human S205 485755 GAEGDVssErEP___ X -CDC7 CDC7 O00311 human LEDGF 11168 O75475 PSIP1 human S206 7231784 MVkQPCPsEsDIItE X X -CDC7 CDC7 O00311 human MCM2 17216 P97310 Mcm2 mouse S40 452311 RRADALtssPGRDLP X -CDC7 CDC7 O00311 human DBF4 10926 Q9UBU7 DBF4 human T273 1211790 QVKLRIQtDGDKyGG X -CDC7 CDC7 O00311 human RAD18 56852 Q9NS91 RAD18 human S434 17595902 IQEVLSSsESDSCNS X X -CDC7 CDC7 O00311 human MCM2 4171 P49736 MCM2 human S53 473058 LPPFEDEsEGLLGtE MCM2_N X X -CDC7 CDC7 O00311 human MCM2 4171 P49736 MCM2 human S139 454180 RRGLLyDsDEEDEER MCM2_N X X 8861; 12958 -CDC7 CDC7 O00311 human claspin 63967 Q9HAW4 CLSPN human S265 36898302 VHsFEEGsELSKGTT X -CDC7 CDC7 O00311 human MCM2 4171 P49736 MCM2 human S27 452310 GNDPLtssPGRssRR X -CDC7 CDC7 O00311 human TOP2A 7153 P11388 TOP2A human S1213 452237 QMAEVLPsPRGQRVI X X -CDC7 CDC7 O00311 human claspin 63967 Q9HAW4 CLSPN human S744 14571708 YFPTEEKsETDENsG X -CDC7 CDC7 O00311 human DTD1 92675 Q8TEA8 DTD1 human S182 36396301 AKGPsEssKERNtPR X -Rps6ka2 RSK3 Q9WUT3 mouse C/EBP-beta 24253 P21272 Cebpb rat S273 13373502 QKKVEQLsRELSTLR bZIP_2 X -TNK1 TNK1 Q13470 human TNK1 8711 Q13470 TNK1 human Y277 474456 LGGARGRyVMGGPRP PK_Tyr_Ser-Thr X 5638 -Tssk4 TSSK4 Q9D411 mouse ODF2 18286 A3KGV1 Odf2 mouse S95 4690005 CLEItPPsSEKLVSV X X -Tssk4 TSSK4 Q9D411 mouse TSSK4 71099 Q9D411 Tssk4 mouse T197 27138201 SLSHLSQtYCGSFAY Pkinase X -Tssk4 TSSK4 Q9D411 mouse CREM iso2 12916 P27699-2 Crem mouse S84 448412 EILSRRPsYRKILNE pKID X X -Map3k12 DLK Q60700 mouse MKK4 26398 P47809 Map2k4 mouse T259 447656 LVDsIAKtRDAGCRP Pkinase X 9151; 9156 -Map3k12 DLK Q60700 mouse MKK4 26398 P47809 Map2k4 mouse S255 447654 ISGQLVDsIAKtRDA Pkinase X 9156; 4514; 59056; 75450 -Rock1 ROCK1 P70335 mouse Diaphanous-3 56419 Q9Z207 Diaph3 mouse S1070 14572460 KLKDIRQsLsPMSQr X X -Rock1 ROCK1 P70335 mouse Vimentin 22352 P20152 Vim mouse S72 449026 ssAVRLRssVPGVRL Filament_head X -Rock1 ROCK1 P70335 mouse calponin 3 71994 Q9DAW9 Cnn3 mouse S293 4776192 QGtGTNGsEIsDsDy X -Rock1 ROCK1 P70335 mouse APP iso2 11820 P12023-2 App mouse S655 448200 LkkkQyTsIHHGVVE APP_amyloid X -Rock1 ROCK1 P70335 mouse FHOD1 234686 Q6P9Q4 Fhod1 mouse T1174 2035402 NRKsLRRtLKSGLGD X -Rock1 ROCK1 P70335 mouse MARCKS 17118 P26645 Marcks mouse S152 447786 kkKKKRFsFKKsFkL MARCKS X X 2741; 11992 -Rock1 ROCK1 P70335 mouse calponin 3 71994 Q9DAW9 Cnn3 mouse S296 4776198 GTNGsEIsDsDyQAE X -Rock1 ROCK1 P70335 mouse Diaphanous-3 56419 Q9Z207 Diaph3 mouse T1061 20583304 FRDRRKRtPKLKDIR X X -Rock1 ROCK1 P70335 mouse K5 110308 Q922U2 Krt5 mouse T160 900975703 PTIQRVRtEEREQIK X -Rock1 ROCK1 P70335 mouse PAR3-alpha 93742 Q99NH2 Pard3 mouse T830 2512944 QsMsEKRtkQFsDAs X -MAPK8 JNK1 iso2 P45983-2 human EWS 2130 Q01844 EWSR1 human T79 7359501 QPPTGYTtPTAPQAY X X -GSK3B GSK3B P49841 human Src 6714 P12931 SRC human S51 2420700 AdGHRGPsAAFAPAA X X -GSK3B GSK3B P49841 human ataxin-3 110616 Q9CVD2 Atxn3 mouse S29 13421402 LLQGEYFsPVELSSI Josephin X X -GSK3B GSK3B P49841 human SREBP-1 6720 P36956 SREBF1 human S434 6729302 PPPsDAGsPFQSsPL X X -GSK3B GSK3B P49841 human Tau iso8 4137 P10636-8 MAPT human T231 449079 KKVAVVRtPPKsPss X X 20473; 71429 -GSK3B GSK3B P49841 human OGT 8473 O15294 OGT human S3 27713500 _____MAssVGNVAD X X -GSK3B GSK3B P49841 human GRB14 2888 Q14449 GRB14 human S362 31834912 QGRsGCSsQSIsPMR X X -GSK3B GSK3B P49841 human PSEN1 5663 P49768 PSEN1 human S353 448562 sHLGPHRstPEsRAA Presenilin X X -GSK3B GSK3B P49841 human AHR 196 P35869 AHR human S723 1874101928 ELDYPMGsFEPsPYP X -GSK3B GSK3B P49841 human CLASP2 23122 O75122 CLASP2 human S507 481392 QGCsREAsPsRLsVA X -GSK3B GSK3B P49841 human BORA 79866 Q6PGQ7 BORA human S278 27724403 PISsPTFsPIEFQIG X X -GSK3B GSK3B P49841 human RXRA 6256 P19793 RXRA human S49 333674901 GSPGQLHsPISTLSS Nuc_recep-AF1 X -GSK3B GSK3B P49841 human Tau iso8 4137 P10636-8 MAPT human S199 447927 GDRsGyssPGsPGtP X X 29957 -GSK3B GSK3B P49841 human AHR 196 P35869 AHR human S440 1874101918 NGTsGkDsATTsTLS X -GSK3B GSK3B P49841 human C/EBP-beta 12608 P28033 Cebpb mouse T179 455887 GSsGsLStssSssPP X X -GSK3B GSK3B P49841 human ACF7 23499 Q9UPN3 MACF1 human S7314 15427027 KSAsRPGsRAGsRAG X X -GSK3B GSK3B P49841 human SEPT4 18952 P28661 Septin4 mouse S100 4705460 FSAPAPLsPSSRPRs X -GSK3B GSK3B P49841 human MNX1 15285 Q9QZW9 Mnx1 mouse S78 3191341 GDRLRAEsPsPPRLL X X -GSK3B GSK3B P49841 human Jun 3725 P05412 JUN human S243 450451 PGEtPPLsPIDMEsQ X 2994 -GSK3B GSK3B P49841 human SUFU 51684 Q9UMX1 SUFU human S342 4786843 LAHDRAPsRkDsLEs SUFU_C X -GSK3B GSK3B P49841 human Fe65 322 O00213 APBB1 human T579 288031700 SSSREQWtPSHVSVA PID X X -GSK3B GSK3B P49841 human myocardin 214384 Q8VIM5 Myocd mouse S458 3627512 HFGsTSSsPPIsPAS X X -GSK3B GSK3B P49841 human IRF3 3661 Q14653 IRF3 human T180 28095000 sPsLDNPtPFPNLGP X X -GSK3B GSK3B P49841 human AHR 196 P35869 AHR human T697 1874101926 EMDsMPYtQNFISCN X -GSK3B GSK3B P49841 human TNKS 8658 O95271 TNKS human T982 471334 SLIsPAStPSCLsAA X -GSK3B GSK3B P49841 human ERG 2078 P11308 ERG human T180 1870421703 KDDFQRLtPSyNADI SAM_PNT X X -GSK3B GSK3B P49841 human PIAS1 8554 O75925 PIAS1 human S17 53747701 MVMsLRVsELQVLLG X -GSK3B GSK3B P49841 human Tau 29477 P19332 Mapt rat S513 447928 SGyssPGsPGtPGsR X 39357; 30505 -GSK3B GSK3B P49841 human MUC1 4582 P15941 MUC1 human S1227 455675 PPsstDRsPyEKVsA X -GSK3B GSK3B P49841 human TSC2 24855 P49816 Tsc2 rat S1385 450216 FQPsQPLsKSSsSPE X X -GSK3B GSK3B P49841 human PD-L1 29126 Q9NZQ7 CD274 human S184 63237405 GkTtTTNsKREEKLF C2-set_2 X X -GSK3B GSK3B P49841 human MAFA 389692 Q8NHW3 MAFA human S61 1320401 PLStPCSsVPSsPSF X X -GSK3B GSK3B P49841 human GFI1 2672 Q99684 GFI1 human S94 41452096 EDFWRPPsPSAsPAS X X -GSK3B GSK3B P49841 human HSP70 3303 P0DMV8 HSPA1B human T636 18010647 GGsGsGPtIEEVD__ X -GSK3B GSK3B P49841 human NBR1 4077 Q14596 NBR1 human T586 33602700 HNtPVDVtPCMsPLP X X -GSK3B GSK3B P49841 human NFH 4744 P12036 NEFH human S503 455548 GGEEEtKsPPAEEAA X X -GSK3B GSK3B P49841 human DRP1 10059 O00429 DNM1L human S40 31872528 TQSSGKSsVLEsLVG Dynamin_N X X -GSK3B GSK3B P49841 human NRF2 18024 Q60795 Nfe2l2 mouse S335 18258505 MEFNDSDsGIsLNTs X X -GSK3B GSK3B P49841 human NDR1 11329 Q15208 STK38 human T7 22553317 _MAMtGstPCssMsN X X -GSK3B GSK3B P49841 human GATA6 2627 Q92908 GATA6 human S37 15419868 REPStPPsPIsSSSS X -GSK3B GSK3B P49841 human myocardin 214384 Q8VIM5 Myocd mouse S624 3627505 GQTHVLSsTFLsPQC X X -GSK3B GSK3B P49841 human CDC25A 993 P30304 CDC25A human S76 449340 SNLQRMGssEstDsG X X -GSK3B GSK3B P49841 human DROSHA 29102 Q9NRR4 DROSHA human S302 14572633 RDNRRsPsLERSYKK X -GSK3B GSK3B P49841 human ZBED3 72114 Q9D0L1 Zbed3 mouse S111 6738702 MPCPPPPsPtMAAEG X -GSK3B GSK3B P49841 human PIAS1 8554 O75925 PIAS1 human S13 53747702 ELkQMVMsLRVsELQ X -GSK3B GSK3B P49841 human PLEKHO1 67220 Q9JIY0 Plekho1 mouse S341 12739074 KAKDPPQsPPDSESE X -GSK3B GSK3B P49841 human BAX 581 Q07812 BAX human S163 469571 GGWDGLLsYFGtPTW X X -GSK3B GSK3B P49841 human FBXL20 84961 Q96IG2 FBXL20 human T417 467016 HAYFAPVtPPPsVGG X X -GSK3B GSK3B P49841 human PSF 6421 P23246 SFPQ human T687 449362 PrGMGPGtPAGyGrG X X -GSK3B GSK3B P49841 human MAFA 378435 Q8CF90 Mafa mouse T53 1320402 PPGsLSStPLStPCS X -GSK3B GSK3B P49841 human EIF6 3692 P56537 EIF6 human S235 450271 QPstIAtsMRDsLID X -GSK3B GSK3B P49841 human IL22RA1 230828 Q80XZ4 Il22ra1 mouse S414 33373903 VEDsGKDsTPGILST X X -GSK3B GSK3B P49841 human ER-alpha 2099 P03372 ESR1 human S104 448099 FPPLNsVsPsPLMLL Oest_recep X X -GSK3B GSK3B P49841 human AKAP11 11215 Q9UKA4 AKAP11 human T1136 40509053 AKEFAPAtPPStPHN X -GSK3B GSK3B P49841 human HDAC4 9759 P56524 HDAC4 human S302 17797200 APGsGPSsPNNSSGS X X -GSK3B GSK3B P49841 human Tip60 10524 Q92993 KAT5 human S86 448826 TKNGLPGsRPGsPER X X -GSK3B GSK3B P49841 human MEF2D 81518 O89038 Mef2d rat S153 10359102 VPVsNQSsMQFSNPS HJURP_C X X -GSK3B GSK3B P49841 human USF1 7391 P22415 USF1 human S186 15428820 APRTHPYsPKsEAPR X X -GSK3B GSK3B P49841 human Securin 9232 O95997 PTTG1 human S184 20764100 NLLQSPssILSTLDV Securin X X -GSK3B GSK3B P49841 human PTEN 5728 P60484 PTEN human S362 456460 SNPEASSsTSVtPDV X -GSK3B GSK3B P49841 human ACF7 23499 Q9UPN3 MACF1 human S7222 18507012 FRsRGRRsKPSsRAA X X -GSK3B GSK3B P49841 human STAT2 6773 P52630 STAT2 human S393 1869778702 LtPEKGQsQGLIWDF STAT_bind X X -GSK3B GSK3B P49841 human 5-HT(1B) 15551 P28334 Htr1b mouse S154 10897604 ITDAVEYsAKRtPKR 7tm_1 X -GSK3B GSK3B P49841 human SQLE 6713 Q14534 SQLE human S87 1877421602 WAKsPPEsENkEQLE X X -GSK3B GSK3B P49841 human SPAG5 10615 Q96R06 SPAG5 human T978 1261101 AEMsIMTtELQSLCS X X -GSK3B GSK3B P49841 human ZNF281 23528 Q9Y2X9 ZNF281 human S638 31881319 PRVDLHtsGEHsELV X X -GSK3B GSK3B P49841 human p21Cip1 1026 P38936 CDKN1A human S114 478191 EEDHVDLsLSCTLVP X X -GSK3B GSK3B P49841 human FOXP3 50943 Q9BZS1 FOXP3 human S270 56786300 kMALTkAsSVAssDK X -GSK3B GSK3B P49841 human RFX1 5989 P22670 RFX1 human T124 31871835 sEAsPGStAsQTGVP X -GSK3B GSK3B P49841 human HSP90B 3326 P08238 HSP90AB1 human S718 3177650 LEGDEDAsRMEEVD_ X -GSK3B GSK3B P49841 human MCL1 4170 Q07820 MCL1 human S159 460683 NNtStDGsLPstPPP X X -GSK3B GSK3B P49841 human Tau 29477 P19332 Mapt rat S510 447927 GERSGyssPGsPGtP X 29957 -GSK3B GSK3B P49841 human CCNE1 898 P24864 CCNE1 human S73 2585500 AVCADPCsLIPtPDK X -GSK3B GSK3B P49841 human myocardin 214384 Q8VIM5 Myocd mouse S628 3627510 VLSsTFLsPQCsPQH X X -GSK3B GSK3B P49841 human GYS1 2997 P13807 GYS1 human S641 448237 yRyPRPAsVPPsPsL Glycogen_syn X 3891; 98074; 47043 -GSK3B GSK3B P49841 human ZAP 252832 Q8K3Y6 Zc3hav1 rat S279 3203922 PPsPDVTsCKDsLED X -GSK3B GSK3B P49841 human CLASP2 23122 O75122 CLASP2 human S499 22349877 KRsKIPRsQGCsREA X -GSK3B GSK3B P49841 human RASSF1 iso2 11186 Q9NS23-2 RASSF1 human S178 13258705 VRPVsVPssKKPPsL X -GSK3B GSK3B P49841 human desmin 1674 P17661 DES human S32 466343 PLGsPLssPVFPrAG Filament_head X -GSK3B GSK3B P49841 human PDX1 29535 P52947 Pdx1 rat S268 11279404 LPSGLSAsPQPsSIA X X -GSK3B GSK3B P49841 human CTNNB1 1499 P35222 CTNNB1 human S37 447582 yLDsGIHsGATtTAP X X 9561; 2009; 4270; 13537; 41334; 60180 -GSK3B GSK3B P49841 human RASSF1 iso2 11186 Q9NS23-2 RASSF1 human S175 13258707 LKLVRPVsVPssKKP X -GSK3B GSK3B P49841 human VDAC1 7416 P21796 VDAC1 human T107 3181799 DssFsPNtGkkNAKI Porin_3 X -GSK3B GSK3B P49841 human AMPKA1 5562 Q13131 PRKAA1 human T482 3195164 RSIDDEItEAksGtA AdenylateSensor X X -GSK3B GSK3B P49841 human PHLPP 23239 O60346 PHLPP1 human S1379 22769302 GSKGLWDsLsVEEAV PP2C X -GSK3B GSK3B P49841 human CDH1 12550 P09803 Cdh1 mouse S849 465568 sEAAsLssLNSsEsD CADH_Y-type_LIR X -GSK3B GSK3B P49841 human FBXL21 213311 Q8BFZ4 Fbxl21 mouse S37 1880462804 LRQtHALsVLLDWGT X -GSK3B GSK3B P49841 human GLE1 2733 Q53GS7 GLE1 human S99 18010022 ssAFsPAsPAtPNGT X -GSK3B GSK3B P49841 human MAFA 378435 Q8CF90 Mafa mouse S65 5403102 PCSsVPSsPSFCAPS X -GSK3B GSK3B P49841 human FBXL20 84961 Q96IG2 FBXL20 human S251 1875005604 RGCHKLQsLCAsGCS X X -GSK3B GSK3B P49841 human TNKS 8658 O95271 TNKS human S991 471336 SCLsAASsIDNLTGP X -GSK3B GSK3B P49841 human Snail2 6591 O43623 SNAI2 human S96 25603908 PPPsDTSsKDHsGSE X X -GSK3B GSK3B P49841 human SPAG5 10615 Q96R06 SPAG5 human S974 1261100 EESLAEMsIMTtELQ X X -GSK3B GSK3B P49841 human AMPKA1 5562 Q13131 PRKAA1 human S486 3195155 DEItEAksGtAtPQR AdenylateSensor X X -GSK3B GSK3B P49841 human SOX2 6657 P48431 SOX2 human S251 6738002 VksEAsssPPVVtSS X X 92186 -GSK3B GSK3B P49841 human Tau iso8 4137 P10636-8 MAPT human S396 449081 GAEIVyKsPVVsGDt X X 9632 -GSK3B GSK3B P49841 human p53 7157 P04637 TP53 human S376 447570 LkskkGQstsRHkkL X -GSK3B GSK3B P49841 human FBXL20 84961 Q96IG2 FBXL20 human S255 1875005606 KLQsLCAsGCSNITD X X -GSK3B GSK3B P49841 human MYBPC3 4607 Q14896 MYBPC3 human S304 471081 SLLKKRDsFRtPRDs X -GSK3B GSK3B P49841 human IL17RA 16172 Q60943 Il17ra mouse T779 41452470 EVVLEGCtPSEEEQR X -GSK3B GSK3B P49841 human E2F1 1869 Q01094 E2F1 human T433 447871 DCDFGDLtPLDF___ X -GSK3B GSK3B P49841 human Tau iso8 4137 P10636-8 MAPT human S404 449082 PVVsGDtsPRHLsNV X X 35834; 20194; 98523; 91600; 49562 -GSK3B GSK3B P49841 human DRP1 10059 O00429 DNM1L human S44 31866197 GKSsVLEsLVGRDLL Dynamin_N X X -GSK3B GSK3B P49841 human BCLAF1 9774 Q9NYF8 BCLAF1 human S531 455195 KstFREEsPLRIkMI THRAP3_BCLAF1 X -GSK3B GSK3B P49841 human MITF iso9 4286 O75030-9 MITF human S298 448503 QARAHGLsLIPSTGL DUF3371 X -GSK3B GSK3B P49841 human MAFA 389692 Q8NHW3 MAFA human T57 456028 LSStPLStPCSsVPS X X -GSK3B GSK3B P49841 human Raptor 57521 Q8N122 RPTOR human S792 2314600 DKMRRAssYSsLNSL X 2083; 89146 -GSK3B GSK3B P49841 human smMLCK 396445 P11799 MYLK chicken S1765 468781 GRKAsGssPTsPINA X -GSK3B GSK3B P49841 human ACF7 23499 Q9UPN3 MACF1 human S7318 18507010 RPGsRAGsRAGsRAs X X -GSK3B GSK3B P49841 human SOX9 6662 P48436 SOX9 human T236 40722389 GQSQGPPtPPtTPKT X -GSK3B GSK3B P49841 human PR iso2 5241 P06401-2 PGR human S390 11273301 PDSEASQsPQYsFES Prog_receptor X X -GSK3B GSK3B P49841 human CdGAP 12549 A6X8Z5 Arhgap31 mouse T776 456517 tPAPPPPtPLEEEPE X X -GSK3B GSK3B P49841 human CTNNB1 1499 P35222 CTNNB1 human S45 447488 GATtTAPsLsGkGNP X 9565; 9564; 24710; 70034; 19807; 96727; 77605 -GSK3B GSK3B P49841 human Tau iso8 4137 P10636-8 MAPT human S262 447930 NVKskIGstENLkHQ Tubulin-binding X X -GSK3B GSK3B P49841 human myocardin 214384 Q8VIM5 Myocd mouse S462 3627507 TSSsPPIsPASsDLS X X -GSK3B GSK3B P49841 human DYN1 140694 P21575 Dnm1 rat S774 450205 SVPAGRRsPTSsPTP X X -GSK3B GSK3B P49841 human CABYR 26256 O75952 CABYR human T151 11454101 PATPKTTtPPSsPPP X -GSK3B GSK3B P49841 human ENDOG 2021 Q14249 ENDOG human S288 1871762500 NILARAGsLkAITAG X X -GSK3B GSK3B P49841 human CAP1 10487 Q01518 CAP1 human S310 2525971 PKPQtsPsPkRAtKk X -GSK3B GSK3B P49841 human CLASP2 23122 O75122 CLASP2 human S537 22648007 REAsREssRDTsPVR X X -GSK3B GSK3B P49841 human Raptor 57521 Q8N122 RPTOR human S877 3205938 HIHQAGGsPPAssts X -GSK3B GSK3B P49841 human GSK3B 2932 P49841 GSK3B human Y216 448569 RGEPNVsyICsRyyR Pkinase X X -GSK3B GSK3B P49841 human GCM1 8521 Q9NP62 GCM1 human S322 7979600 NYPFPLTsWPCsFSP X X -GSK3B GSK3B P49841 human myocardin 214384 Q8VIM5 Myocd mouse S454 3627508 TGFYHFGsTSSsPPI X X -GSK3B GSK3B P49841 human ULK1 22241 O70405 Ulk1 mouse S415 4958506 CSSSPSPsGRPGPFS X -GSK3B GSK3B P49841 human DNMT1 1786 P26358 DNMT1 human S714 452655 DNIPEMPsPkKMHQG X X -GSK3B GSK3B P49841 human C/EBP-delta 1052 P49716 CEBPD human T171 28852501 PRSsPRQtPAPGPAR X -GSK3B GSK3B P49841 human LRP6 4040 O75581 LRP6 human S1490 456289 AILNPPPsPAtERsH X X 2568 -GSK3B GSK3B P49841 human KLC2 64837 Q9H0B6 KLC2 human S608 4693027 LsDSRtLssssMDLs X -GSK3B GSK3B P49841 human MAFA 389692 Q8NHW3 MAFA human S49 1320400 CHRLPPGsLSStPLS X X -GSK3B GSK3B P49841 human SREBP-1 iso1 78968 P56720-1 Srebf1 rat S73 14580856 KVTPAPLsPPPSAPT X -GSK3B GSK3B P49841 human RICTOR 253260 Q6R327 RICTOR human T1695 40638601 EAEAVLAtPPKQPIV X -GSK3B GSK3B P49841 human FBXL20 84961 Q96IG2 FBXL20 human S139 1875005600 DATCTSLskFCsKLR X X -GSK3B GSK3B P49841 human EB1 22919 Q15691 MAPRE1 human S156 1259758900 PkkPLtssSAAPQRP X -GSK3B GSK3B P49841 human Snail1 6615 O95863 SNAI1 human S119 6097706 sFSsTSVsSLEAEAY X X -GSK3B GSK3B P49841 human eIF2B-epsilon 192234 Q64350 Eif2b5 rat S535 449905 VDPEELDsRAGsPQL X -GSK3B GSK3B P49841 human APP 54226 P08592 App rat T743 448523 VEVDAAVtPEERHLS APP_amyloid X 3823; 6986 -GSK3B GSK3B P49841 human IKKG 8517 Q9Y6K9 IKBKG human S43 449037 PAMLHLPsEQGAPEt X -GSK3B GSK3B P49841 human FBXL21 213311 Q8BFZ4 Fbxl21 mouse T33 1870414702 LCSSLRQtHALsVLL X -GSK3B GSK3B P49841 human Myc 4609 P01106 MYC human T73 448496 kkFELLPtPPLsPsR Myc_N X X 46650 -GSK3B GSK3B P49841 human SOX4 20677 Q06831 Sox4 mouse S315 50800249 SGRSSAAssPAASRS X -GSK3B GSK3B P49841 human CDX2 1045 Q99626 CDX2 human S283 456208 RsVPEPLsPVSSLQA X -GSK3B GSK3B P49841 human CTPS 1503 P17812 CTPS1 human S571 457565 RDtysDrsGsssPDs X X -GSK3B GSK3B P49841 human ZBED3 72114 Q9D0L1 Zbed3 mouse T113 6738703 CPPPPsPtMAAEGDW X -GSK3B GSK3B P49841 human CRMP-4 1809 Q14195 DPYSL3 human T514 458798 tttPkGGtPAGsArG X X -GSK3B GSK3B P49841 human SERCA2 488 P16615 ATP2A2 human S663 452253 EFDELNPsAQRDACL X -GSK3B GSK3B P49841 human PHLPP 23239 O60346 PHLPP1 human T1363 22769303 HVQsVLLtPQDEFFI PP2C X -GSK3B GSK3B P49841 human USF1 7391 P22415 USF1 human T153 463815 EALLGQAtPPGTGQF X X -GSK3B GSK3B P49841 human C/EBP-beta 12608 P28033 Cebpb mouse S184 455886 LStssSssPPGtPSP X -GSK3B GSK3B P49841 human ACF7 23499 Q9UPN3 MACF1 human S7322 18507008 RAGsRAGsRAssRRG X X -GSK3B GSK3B P49841 human Tau iso8 4137 P10636-8 MAPT human T153 449076 DGKtKIAtPRGAAPP X -GSK3B GSK3B P49841 human Tau iso3 4137 P10636-3 MAPT human S199 449328 KVTSKCGsLGNIHHK Tubulin-binding X -GSK3B GSK3B P49841 human Src 6714 P12931 SRC human S43 31885161 QtPsKPAsAdGHRGP X -GSK3B GSK3B P49841 human PKCE 5581 Q02156 PRKCE human S346 2807904 sEEDRsKsAPtsPCD X X -GSK3B GSK3B P49841 human PR iso2 5241 P06401-2 PGR human S164 28706301 RQLLEDEsYDGGAGA Prog_receptor X -GSK3B GSK3B P49841 human GYS1 100008660 P13834 GYS1 rabbit S645 448238 RPAsVPPsPSLsRHS Glycogen_syn X -GSK3B GSK3B P49841 human SERCA2 11938 O55143 Atp2a2 mouse S663 452253 EFDELsPsAQRDACL X -GSK3B GSK3B P49841 human HRas 3265 P01112 HRAS human T144 25324400 yGIPYIEtsAktRQG Ras X X -GSK3B GSK3B P49841 human FCAR 2204 P24071 FCAR human S284 1870031100 LTFARTPsVCK____ X -GSK3B GSK3B P49841 human PDX1 18609 P52946 Pdx1 mouse S66 458402 QGsPPDIsPYEVPPL X -GSK3B GSK3B P49841 human NIFK 84365 Q9BYG3 NIFK human S230 457632 tPEKtVDsQGPtPVC hNIFK_binding X -GSK3B GSK3B P49841 human CREB 1385 P16220 CREB1 human S115 450092 QKRREILsRRPsyRk pKID X -GSK3B GSK3B P49841 human MITF iso9 4286 O75030-9 MITF human S405 31858102 PGAsKTSsRRSsMSM DUF3371 X -GSK3B GSK3B P49841 human STAT3 6774 P40763 STAT3 human S727 448191 NtIDLPMsPrTLDSL X X 9134; 9136; 34911; 94994; 49081; 58978; 87544; 71958; 50804 -GSK3B GSK3B P49841 human LPCAT1 210992 Q3TFD2 Lpcat1 mouse S182 17533101 VSRsDQDsRRKTVEE Acyltransferase X -GSK3B GSK3B P49841 human RBM38 55544 Q9H0Z9 RBM38 human S195 29606707 DQYPYAAsPATAASF X X -GSK3B GSK3B P49841 human RELB 5971 Q01201 RELB human S573 450233 AFGGGLLsPGPEAt_ RelB_transactiv X 4999; 13567; 5025; 17616 -GSK3B GSK3B P49841 human IRF1 16362 P15314 Irf1 mouse T181 1380568700 LDMERDItPALsPCV X -GSK3B GSK3B P49841 human MCL1 4170 Q07820 MCL1 human S121 1172400 PAADAIMsPEEELDG X -GSK3B GSK3B P49841 human NFkB-p65 5970 Q04206 RELA human S468 451145 AVFTDLAsVDNsEFQ X X 3039 -GSK3B GSK3B P49841 human GR 14815 P06537 Nr3c1 mouse S421 5044100 GMRPDVSsPPSSSST X -GSK3B GSK3B P49841 human FOXP3 50943 Q9BZS1 FOXP3 human S274 34370255 TkAsSVAssDKGSCC X -GSK3B GSK3B P49841 human PDX1 29535 P52947 Pdx1 rat S272 11279403 LSAsPQPsSIAPLRP X -GSK3B GSK3B P49841 human CRMP-2 1808 Q16555 DPYSL2 human T509 448083 PVCEVsVtPktVtPA X -GSK3B GSK3B P49841 human CRMP-2 1808 Q16555 DPYSL2 human T514 454386 sVtPktVtPAssAkt X X 9397 -GSK3B GSK3B P49841 human C/EBP-beta 1051 P17676 CEBPB human S223 2902801 VPsGSSGsLsTSSss X -GSK3B GSK3B P49841 human MAFA 378435 Q8CF90 Mafa mouse S49 1320400 CHRLPPGsLSStPLS X -GSK3B GSK3B P49841 human SRF 6722 P11831 SRF human S224 468829 TCLNsPDsPPRsDPT X -GSK3B GSK3B P49841 human ZAP 252832 Q8K3Y6 Zc3hav1 rat S257 469059 RDRFLHNsLEFLsPV X X -GSK3B GSK3B P49841 human desmin 1674 P17661 DES human S28 4705787 APGFPLGsPLssPVF Filament_head X -GSK3B GSK3B P49841 human desmin Q5XFN2 DES dog S32 466343 PLGsPLGsPVFPRAG Filament_head X -GSK3B GSK3B P49841 human CCND1 595 P24385 CCND1 human T286 447839 EEVDLACtPtDVRDV X X 3300; 94159 -GSK3B GSK3B P49841 human FBXL20 84961 Q96IG2 FBXL20 human S425 4149424 PPPsVGGsRQRFCRC X X -GSK3B GSK3B P49841 human Bcl-xL 598 Q07817 BCL2L1 human S62 449099 PSWHLADsPAVNGAT X -GSK3B GSK3B P49841 human NRF2 4780 Q16236 NFE2L2 human S347 18258501 NDSDsGIsLNTsPSV X X -GSK3B GSK3B P49841 human L-Myc 4610 P12524 MYCL human S38 448140 KKFELVPsPPtsPPW Myc_N X -GSK3B GSK3B P49841 human Snail1 6615 O95863 SNAI1 human S100 6097704 DEDsGkGsQPPsPPs X X -GSK3B GSK3B P49841 human OSBP2 23762 Q969R2 OSBP2 human S762 11171320 ECSKVMHssPssPsS Oxysterol_BP X -GSK3B GSK3B P49841 human H1B 3009 P16401 H1-5 human T11 458351 tAPAEtAtPAPVEks X X -GSK3B GSK3B P49841 human AKAP11 11215 Q9UKA4 AKAP11 human T1140 41313700 APAtPPStPHNSSVG X -GSK3B GSK3B P49841 human GYS1 2997 P13807 GYS1 human S653 448240 PsLsRHssPHQsEDE Glycogen_syn X -GSK3B GSK3B P49841 human MITF iso9 4286 O75030-9 MITF human S401 11125701 SSVsPGAsKTSsRRS DUF3371 X -GSK3B GSK3B P49841 human UNG 7374 P13051 UNG human S64 2018601 EPGtPPssPLsAEQL X -GSK3B GSK3B P49841 human OGT 8473 O15294 OGT human S4 27713501 ____MAssVGNVADS X X -GSK3B GSK3B P49841 human PSD-95 29495 P31016 Dlg4 rat T19 3609101 YRYQDEDtPPLEHSP X -GSK3B GSK3B P49841 human PICK1 9463 Q9NRD5 PICK1 human S342 25749628 QRLVsTMsKYYNDCy Arfaptin X -GSK3B GSK3B P49841 human APC 324 P25054 APC human S1501 999605 ESTPDGFsCsssLsA APC_r X -GSK3B GSK3B P49841 human CTNNB1 12387 Q02248 Ctnnb1 mouse T41 447583 GIHsGATtTAPsLsG X 9561; 9565; 4270; 13537; 41334; 60180 -GSK3B GSK3B P49841 human ACF7 23499 Q9UPN3 MACF1 human S7226 18507015 GRRsKPSsRAAsPTR X X -GSK3B GSK3B P49841 human BMAL1 406 O00327 BMAL1 human T21 12575204 DFMsPGPtDLLSSSL X X -GSK3B GSK3B P49841 human STMN3 50861 Q9NZ72 STMN3 human S60 4698871 sFEVILksPSDLsPE Stathmin X -GSK3B GSK3B P49841 human E2F1 1869 Q01094 E2F1 human S403 447870 PEEFISLsPPHEALD X -GSK3B GSK3B P49841 human RAPH1 65059 Q70E73 RAPH1 human S1071 1883958002 FPsPPsDsDFPPPPP X -GSK3B GSK3B P49841 human CRMP-4 25418 Q62952 Dpysl3 rat T509 454328 PVFDLTTtPKGGtPA X -GSK3B GSK3B P49841 human RFX1 5989 P22670 RFX1 human S120 452650 SETVsEAsPGStAsQ X -GSK3B GSK3B P49841 human SREBP-1 6720 P36956 SREBF1 human T426 467200 TEVEDTLtPPPsDAG X X -GSK3B GSK3B P49841 human CLOCK 9575 O15516 CLOCK human S427 7911903 ALERFDHsPtPsASs X -GSK3B GSK3B P49841 human MAP2 iso3 25595 P15146-3 Map2 rat T259 450181 YSSRTPGtPGtPSYP X -GSK3B GSK3B P49841 human CCND3 896 P30281 CCND3 human T283 452160 QGPsQtstPtDVtAI X X 53966 -GSK3B GSK3B P49841 human GYS1 14936 Q9Z1E4 Gys1 mouse S641 448237 YRyPRPAsVPPsPsL Glycogen_syn X 3891; 98074; 47043 -GSK3B GSK3B P49841 human RCAN1 1827 P53805 RCAN1 human S163 456022 PDKQFLIsPPAsPPV Calcipressin X -GSK3B GSK3B P49841 human OSBP2 23762 Q969R2 OSBP2 human S766 15721694 VMHssPssPsSDGKQ Oxysterol_BP X -GSK3B GSK3B P49841 human UNG 7374 P13051 UNG human T60 452622 AGQEEPGtPPssPLs X X -GSK3B GSK3B P49841 human ADD2 119 P35612 ADD2 human S693 454590 SVTSGPMsPEGsPsK X -GSK3B GSK3B P49841 human MOB1A 232157 Q921Y0 Mob1a mouse S146 1214257701 PFPKNFMsVAKTILK Mob1_phocein X -GSK3B GSK3B P49841 human FBXL20 84961 Q96IG2 FBXL20 human S143 1875005602 TSLskFCsKLRHLDL LRR_6 X X -GSK3B GSK3B P49841 human Tau iso8 4137 P10636-8 MAPT human S409 449132 DtsPRHLsNVsstGs X -GSK3B GSK3B P49841 human Snail1 6615 O95863 SNAI1 human S107 455882 sQPPsPPsPAPssFS X X -GSK3B GSK3B P49841 human GYS1 100008660 P13834 GYS1 rabbit S653 448240 PSLsRHSsPHQsEDE Glycogen_syn X -GSK3B GSK3B P49841 human IKKG 8517 Q9Y6K9 IKBKG human S8 62382604 MNRHLWKsQLCEMVQ X X -GSK3B GSK3B P49841 human WT1 iso7 7490 P19544-7 WT1 human S69 1871128701 RsRGAsGsEPQQMGs X -GSK3B GSK3B P49841 human FAK 396416 Q00944 PTK2 chicken S722 447962 PSRPGYPsPRSsEGF X X -GSK3B GSK3B P49841 human IL1RL1 17082 P14719 Il1rl1 mouse S442 25585004 AATVVESsIQNsRRQ TIR X -GSK3B GSK3B P49841 human GLE1 2733 Q53GS7 GLE1 human T102 472369 FsPAsPAtPNGTKGk X -GSK3B GSK3B P49841 human PSEN1 5663 P49768 PSEN1 human S357 448563 PHRstPEsRAAVQEL Presenilin X X -GSK3B GSK3B P49841 human DROSHA 29102 Q9NRR4 DROSHA human S300 14572630 RHRDNRRsPsLERSY X -GSK3B GSK3B P49841 human RAPH1 65059 Q70E73 RAPH1 human S1069 1883958000 VEFPsPPsDsDFPPP X -GSK3B GSK3B P49841 human BMAL1 406 O00327 BMAL1 human S17 12575203 STISDFMsPGPtDLL X X -GSK3B GSK3B P49841 human PPP1R16B 282091 Q95N27 PPP1R16B cow S333 486244 LRHKSSLsRRTsSAG X -GSK3B GSK3B P49841 human NR1D1 9572 P20393 NR1D1 human S59 471092 FPPsPTGsLTQDPAR X X 2129 -GSK3B GSK3B P49841 human STAT3 6774 P40763 STAT3 human T714 3190177 ktKFICVtPTtCsNt X X -GSK3B GSK3B P49841 human STAT2 6773 P52630 STAT2 human T385 1869778701 ILTsNQktLtPEKGQ STAT_bind X X -GSK3B GSK3B P49841 human L-Myc 4610 P12524 MYCL human S42 448141 LVPsPPtsPPWGLGP Myc_N X -GSK3B GSK3B P49841 human CRMP-2 1808 Q16555 DPYSL2 human S518 448081 ktVtPAssAktsPAk X X -GSK3B GSK3B P49841 human SMAD4 4089 Q13485 SMAD4 human T265 36694101 ATYHHNStTTWtGSR X -GSK3B GSK3B P49841 human SPAG5 10615 Q96R06 SPAG5 human T111 460413 PIPQIsStPkTsEEA X X -GSK3B GSK3B P49841 human SNCA 6622 P37840 SNCA human S129 448278 NEAyEMPsEEGyQDy Synuclein X X 23706; 87281 -GSK3B GSK3B P49841 human N-Myc 4613 P04198 MYCN human T58 448223 KkFELLPtPPLsPsr Myc_N X 46650 -GSK3B GSK3B P49841 human IRF3 3661 Q14653 IRF3 human S123 4712212 DFSQPDTsPDTNGGG X X -GSK3B GSK3B P49841 human XIAP 331 P98170 XIAP human T180 3801500 WPDYAHLtPRELASA BIR X -GSK3B GSK3B P49841 human SP1 6667 P08047 SP1 human S728 2535904 VGtLPLDsGAGsEGS X -GSK3B GSK3B P49841 human CRMP-2 25416 P47942 Dpysl2 rat T514 454386 SVtPKTVtPASsAKT X X 9397 -GSK3B GSK3B P49841 human BLM 641 P54132 BLM human T171 471430 ETSksFVtPPQsHFV BLM_N X -GSK3B GSK3B P49841 human Tau iso8 4137 P10636-8 MAPT human S46 447926 tDAGLkEsPLQtPtE X 20296 -GSK3B GSK3B P49841 human PDX1 18609 P52946 Pdx1 mouse S61 458401 LGSLEQGsPPDIsPY X -GSK3B GSK3B P49841 human FRAT1 10023 Q92837 FRAT1 human S188 471366 RLQQRRGsQPETRTG GSK-3_bind X -GSK3B GSK3B P49841 human ZAP 252832 Q8K3Y6 Zc3hav1 rat S288 4776633 KDsLEDVsVDVTQKF X -GSK3B GSK3B P49841 human CTNNB1 12387 Q02248 Ctnnb1 mouse S33 447487 QQQsYLDsGIHsGAT X 9561; 2009; 4270; 13537; 41334; 60180 -GSK3B GSK3B P49841 human NFAT1 18019 Q60591 Nfatc2 mouse S215 447845 QNIPAHYsPRtsPIM X -GSK3B GSK3B P49841 human MAFA 389692 Q8NHW3 MAFA human T53 1320402 PPGsLSStPLStPCS X X -GSK3B GSK3B P49841 human neurogenin 3 11925 P70661 Neurog3 mouse S183 35527103 VSQAGNLsPTAsLEE X -GSK3B GSK3B P49841 human AMPKA1 5562 Q13131 PRKAA1 human T490 3195170 EAksGtAtPQRsGsV AdenylateSensor X X -GSK3B GSK3B P49841 human TOP2A 7153 P11388 TOP2A human S1361 455094 sPPKTKtsPKLsNkE X -GSK3B GSK3B P49841 human Raptor 57521 Q8N122 RPTOR human S859 2024885 DtssLtQsAPAsPtN X -GSK3B GSK3B P49841 human 4E-BP1 1978 Q13541 EIF4EBP1 human S65 447527 FLMECrNsPVtktPP eIF_4EBP X 9451; 9456; 13443 -GSK3B GSK3B P49841 human FBXL21 26223 Q9UKT6 FBXL21P human T33 1870414702 FYSSLNQtHTHTVLL X X -GSK3B GSK3B P49841 human NDR1 11329 Q15208 STK38 human S6 22553318 __MAMtGstPCssMs X X -GSK3B GSK3B P49841 human AHR 196 P35869 AHR human S727 1874101930 PMGsFEPsPYPtTSS X -GSK3B GSK3B P49841 human Lu 4059 P50895 BCAM human S596 1713902 PPGEPGLsHsGsEQP X -GSK3B GSK3B P49841 human ACF7 23499 Q9UPN3 MACF1 human S7330 468158 RAssRRGsDAsDFDL X X -GSK3B GSK3B P49841 human NFkB-p100 4791 Q00653 NFKB2 human S711 25234803 PLPsPPTsDsDsDsE X -GSK3B GSK3B P49841 human FOXL2 668 P58012 FOXL2 human S33 21697903 EPEGPPPsPGKGGGG X X -GSK3B GSK3B P49841 human Tau 29477 P19332 Mapt rat S707 449081 GAEIVyKsPVVsGDt X 9632 -GSK3B GSK3B P49841 human TSC2 24855 P49816 Tsc2 rat S1377 469993 ARPtVDLsFQPsQPL X X -GSK3B GSK3B P49841 human Tau iso8 4137 P10636-8 MAPT human S202 447928 sGyssPGsPGtPGsR X X 39357; 30505 -GSK3B GSK3B P49841 human Telethonin 8557 O15273 TCAP human S157 448693 GALRRsLsRSMsQEA Telethonin X X -GSK3B GSK3B P49841 human Snail1 6615 O95863 SNAI1 human S104 455881 GkGsQPPsPPsPAPs X X -GSK3B GSK3B P49841 human FTO 26383 Q8BGW1 Fto mouse S249 1115398000 YSYsCEGsEDEsEDE FTO_NTD X -GSK3B GSK3B P49841 human SOX11 20666 Q7M6Y2 Sox11 mouse S244 454322 SVAKVPAsPTLSSAA X -GSK3B GSK3B P49841 human SCN8A 29710 O88420 Scn8a rat T1936 1040254701 HRDKKEStPSTASLP X -GSK3B GSK3B P49841 human STAT2 6773 P52630 STAT2 human S381 1869778700 RkFNILTsNQktLtP STAT_bind X X -GSK3B GSK3B P49841 human ZAP 252832 Q8K3Y6 Zc3hav1 rat S262 1870336230 HNsLEFLsPVVsPLG X X -GSK3B GSK3B P49841 human NHE3 100009430 P26432 NHE-3 rabbit S526 31839902 MRQsAQKsRDRILNV X -GSK3B GSK3B P49841 human ER-alpha 2099 P03372 ESR1 human S102 449799 GGFPPLNsVsPsPLM Oest_recep X X -GSK3B GSK3B P49841 human SQLE 6713 Q14534 SQLE human S83 1877421600 IGFFWAKsPPEsENk X X -GSK3B GSK3B P49841 human RASSF1 iso2 11186 Q9NS23-2 RASSF1 human S179 13258706 RPVsVPssKKPPsLQ X -GSK3B GSK3B P49841 human SIK 59329 Q9R1U5 Sik1 rat T182 456034 KPGEPLStWCGsPPY Pkinase X -GSK3B GSK3B P49841 human IRS1 25467 P35570 Irs1 rat S332 455323 sDGEGTMsRPAsVDG X X 2580 -GSK3B GSK3B P49841 human SREBP-1 6720 P36956 SREBF1 human S430 467201 DTLtPPPsDAGsPFQ X X -GSK3B GSK3B P49841 human desmin Q5XFN2 DES dog S28 4705787 AGGFPLGsPLGsPVF Filament_head X -GSK3B GSK3B P49841 human GRB14 2888 Q14449 GRB14 human S358 31834913 MHPYQGRsGCSsQSI X X -GSK3B GSK3B P49841 human CEACAM1 634 P13688 CEACAM1 human S508 448536 QQPTQPTsAsPsLTA X -GSK3B GSK3B P49841 human ZAP 252832 Q8K3Y6 Zc3hav1 rat S270 3203916 PVVsPLGsGPPsPDV X X -GSK3B GSK3B P49841 human ER-alpha 2099 P03372 ESR1 human S118 448101 LHPPPQLsPFLQPHG Oest_recep X X 2511 -GSK3B GSK3B P49841 human Tau iso8 4137 P10636-8 MAPT human S400 449130 VyKsPVVsGDtsPRH X X 35834; 20194; 98523; 91600; 49562 -GSK3B GSK3B P49841 human neurogenin 3 11925 P70661 Neurog3 mouse S187 35527102 GNLsPTAsLEEFPGL X -GSK3B GSK3B P49841 human TNKS 8658 O95271 TNKS human S978 471333 VVSASLIsPAStPSC X -GSK3B GSK3B P49841 human neurogenin 2 11924 P70447 Neurog2 mouse S231 2255101 SPYSCTLsPAsPGSD X -GSK3B GSK3B P49841 human ZAP 252832 Q8K3Y6 Zc3hav1 rat S274 3203919 PLGsGPPsPDVTsCK X X -GSK3B GSK3B P49841 human JunB 3726 P17275 JUNB human T255 465822 EARsRDAtPPVsPIN Jun X -GSK3B GSK3B P49841 human RAPH1 65059 Q70E73 RAPH1 human T1123 1883958004 VKKAPPPtRPKRNDs X -GSK3B GSK3B P49841 human FTO 26383 Q8BGW1 Fto mouse S253 27449492 CEGsEDEsEDEsSFE FTO_NTD X -GSK3B GSK3B P49841 human PU.1 6688 P17947 SPI1 human S41 13421401 EYYPYLSsDGESHSD X X -GSK3B GSK3B P49841 human Desmoplakin 1832 P15924 DSP human S2845 40416402 RsGsRsGsRRGsFDA X -GSK3B GSK3B P49841 human GRB14 2888 Q14449 GRB14 human S370 14567758 QSIsPMRsIsENsLV BPS X -GSK3B GSK3B P49841 human OLIG2 50913 Q9EQW6 Olig2 mouse S10 18357903 SDASLVSsRPssPEP X -GSK3B GSK3B P49841 human PTEN 5728 P60484 PTEN human T366 449634 ASSsTSVtPDVsDNE X X -GSK3B GSK3B P49841 human C/EBP-beta 24253 P21272 Cebpb rat T189 447878 SSSsPPGtPSPADAK X X 3084 -GSK3B GSK3B P49841 human CIITA 4261 P33076 CIITA human S373 1295502 VQARLERsSSKSLER X -GSK3B GSK3B P49841 human WT1 iso7 7490 P19544-7 WT1 human S67 56653434 GRRsRGAsGsEPQQM X -GSK3B GSK3B P49841 human ER-alpha 2099 P03372 ESR1 human S106 448100 PLNsVsPsPLMLLHP Oest_recep X X -GSK3B GSK3B P49841 human hnRNP D0 3184 Q14103 HNRNPD human S83 449336 DEGHsNssPRHsEAA X -GSK3B GSK3B P49841 human LPCAT1 210992 Q3TFD2 Lpcat1 mouse S178 17533100 RPVFVSRsDQDsRRK Acyltransferase X -GSK3B GSK3B P49841 human EGLN2 112398 Q96KS0 EGLN2 human S401 62873403 KGVQVPVsQPPtPT_ X -GSK3B GSK3B P49841 human PAX3 18505 P24610 Pax3 mouse S201 18744500 ERASAPQsDEGsDID X -GSK3B GSK3B P49841 human GRB14 2888 Q14449 GRB14 human S423 62887802 THGsPtAsSQSSATN X -GSK3B GSK3B P49841 human GSK3B 2932 P49841 GSK3B human S9 449111 SGRPRttsFAEsCkP X 9336; 9331; 9327; 9323; 9322; 9325; 5558; 8566; 79774; 8466; 25462; 14026; 14332; 14310; 14630 -GSK3B GSK3B P49841 human FANCL 55120 Q9NW38 FANCL human T178 63128909 VPFCASWtPQSSLIS FANCL_d2 X -GSK3B GSK3B P49841 human NFAT1 18019 Q60591 Nfatc2 mouse S223 447847 PRtsPIMsPRTsLAE X -GSK3B GSK3B P49841 human CTNND2 18163 O35927 Ctnnd2 mouse T1078 2020381 RPySSSRtPsIsPVR X X -GSK3B GSK3B P49841 human PKM 5315 P14618 PKM human T328 481749 GkPVICAtQMLESMI PK X X -GSK3B GSK3B P49841 human CTNNB1 12387 Q02248 Ctnnb1 mouse S37 447582 YLDsGIHsGATtTAP X 9561; 2009; 4270; 13537; 41334; 60180 -GSK3B GSK3B P49841 human Tau iso8 4137 P10636-8 MAPT human T217 449078 sRtPsLPtPPtREPK X X 33134; 51625 -GSK3B GSK3B P49841 human LSD1 23028 O60341 KDM1A human S683 57786402 NLFGHVGsTTAsRGE Amino_oxidase X X -GSK3B GSK3B P49841 human ACF7 23499 Q9UPN3 MACF1 human S7230 18507014 KPSsRAAsPTRsssS X X -GSK3B GSK3B P49841 human FBXL2 25827 Q9UKC9 FBXL2 human T404 15278700 HAYFAPVtPPTAVAG X X -GSK3B GSK3B P49841 human Doublecortin iso2 1641 O43602-2 DCX human S327 451363 StPKSKQsPIStPTs X X -GSK3B GSK3B P49841 human TSC2 24855 P49816 Tsc2 rat S1381 450215 VDLsFQPsQPLsKSS X X -GSK3B GSK3B P49841 human IL22RA1 230828 Q80XZ4 Il22ra1 mouse S410 23115552 YAVCVEDsGKDsTPG X X -GSK3B GSK3B P49841 human EIF6 3692 P56537 EIF6 human S243 3193267 MRDsLIDsLt_____ X -GSK3B GSK3B P49841 human Jun 3725 P05412 JUN human T239 450450 VPEMPGEtPPLsPID Jun X -GSK3B GSK3B P49841 human Tau iso8 4137 P10636-8 MAPT human S195 450221 PPKsGDRsGyssPGs X -GSK3B GSK3B P49841 human Tau iso8 4137 P10636-8 MAPT human S214 447929 GsRsRtPsLPtPPtR X 77348 -GSK3B GSK3B P49841 human SMAD1 4086 Q15797 SMAD1 human T202 9693200 sPGSSSStYPHsPTS X -GSK3B GSK3B P49841 human USF2 7392 Q15853 USF2 human T230 3801550 PkIDGtRtPRDERRR X X -GSK3B GSK3B P49841 human EIF6 3692 P56537 EIF6 human T231 31863506 LNEAQPstIAtsMRD X -GSK3B GSK3B P49841 human IKKG 8517 Q9Y6K9 IKBKG human S31 449036 QDVLGEEsPLGKPAM X X -GSK3B GSK3B P49841 human Tau iso8 4137 P10636-8 MAPT human T50 447931 LkEsPLQtPtEDGsE X -GSK3B GSK3B P49841 human CRMP-5 56896 Q9BPU6 DPYSL5 human T516 478232 tPLADtPtRPVTRHG X -GSK3B GSK3B P49841 human NRF2 18024 Q60795 Nfe2l2 mouse S338 18258501 NDSDsGIsLNTsPSR X X -GSK3B GSK3B P49841 human IL17RA 23765 Q96F46 IL17RA human T780 41452470 MVLTDPHtPYEEEQR X -GSK3B GSK3B P49841 human SMAD4 4089 Q13485 SMAD4 human T273 36694102 TTWtGSRtAPYtPNL X -GSK3B GSK3B P49841 human MAFA 378435 Q8CF90 Mafa mouse S61 1320401 PLStPCSsVPSsPSF X -GSK3B GSK3B P49841 human ULK1 22241 O70405 Ulk1 mouse S913 10428808 KVAELLSsGLQTAID DUF3543 X -GSK3B GSK3B P49841 human HRas 3265 P01112 HRAS human T148 23113995 YIEtsAktRQGVEDA Ras X X -GSK3B GSK3B P49841 human 4E-BP1 1978 Q13541 EIF4EBP1 human T70 447528 rNsPVtktPPRDLPt eIF_4EBP X 9455; 13396 -GSK3B GSK3B P49841 human myocardin 214384 Q8VIM5 Myocd mouse S466 3627506 PPIsPASsDLSAAGS X X -GSK3B GSK3B P49841 human JunB 3726 P17275 JUNB human S251 465702 QTVPEARsRDAtPPV Jun X -GSK3B GSK3B P49841 human Snail2 6591 O43623 SNAI2 human S104 25603909 KDHsGSEsPISDEEE X X -GSK3B GSK3B P49841 human HSP90A 3320 P07900 HSP90AA1 human S726 3180213 LEGDDDtsRMEEVD_ X -GSK3B GSK3B P49841 human CAP1 12331 P40124 Cap1 mouse S309 2525971 PKPQtsPsPKPAtKK X -GSK3B GSK3B P49841 human Aiolos 22806 Q9UKT9 IKZF3 human S378 4696322 VPSERGLsPNNSGHD X -GSK3B GSK3B P49841 human Ets-1 2113 P14921 ETS1 human S269 1873117008 DRLtQsWssQssFNs Ets1_N_flank X -GSK3B GSK3B P49841 human TSC2 24855 P49816 Tsc2 rat T1373 469994 SSEGARPtVDLsFQP X X -GSK3B GSK3B P49841 human CREB iso1 81646 P15337-1 Creb1 rat S129 450092 QKRREILsRRPsYRk pKID X -GSK3B GSK3B P49841 human RAB11FIP5 26056 Q9BXF6 RAB11FIP5 human T276 32674000 GPGAELLtRsPsRss X X -GSK3B GSK3B P49841 human SP1 6667 P08047 SP1 human S732 2535903 PLDsGAGsEGSGtAt X -GSK3B GSK3B P49841 human SMAD4 4089 Q13485 SMAD4 human T269 36694100 HNStTTWtGSRtAPY X -GSK3B GSK3B P49841 human WT1 iso7 7490 P19544-7 WT1 human S63 1871128700 ERLQGRRsRGAsGsE X X -GSK3B GSK3B P49841 human TNKS 8658 O95271 TNKS human S987 471335 AStPSCLsAASsIDN X -GSK3B GSK3B P49841 human HSP90A 3320 P07900 HSP90AA1 human T725 3180216 PLEGDDDtsRMEEVD X -GSK3B GSK3B P49841 human smMLCK 4638 Q15746 MYLK human S1776 468781 GRKsstGsPtsPLNA X -GSK3B GSK3B P49841 human NR1D1 9572 P20393 NR1D1 human S55 471091 CPTYFPPsPTGsLTQ X X 2129 -GSK3B GSK3B P49841 human FBXO4 26272 Q9UKT5 FBXO4 human S12 453026 EPRsGtNsPPPPFSD X X -GSK3B GSK3B P49841 human ACF7 23499 Q9UPN3 MACF1 human S7234 18507013 RAAsPTRsssSAsQs X X -GSK3B GSK3B P49841 human AHR 196 P35869 AHR human S444 1874101920 GkDsATTsTLSKDSL X -GSK3B GSK3B P49841 human Snail2 6591 O43623 SNAI2 human S100 25603907 DTSsKDHsGSEsPIS X X -GSK3B GSK3B P49841 human MLK3 4296 Q16584 MAP3K11 human S789 487506 VsAGPRPsPLPsPQP X X -GSK3B GSK3B P49841 human CRMP-4 25418 Q62952 Dpysl3 rat T514 458798 TTtPKGGtPAGsTRG X -GSK3B GSK3B P49841 human Raptor 57521 Q8N122 RPTOR human S863 453732 LtQsAPAsPtNkGVH X -GSK3B GSK3B P49841 human CRMP-4 25418 Q62952 Dpysl3 rat S518 458799 KGGtPAGsTRGsPTR X -GSK3B GSK3B P49841 human Tau iso8 4137 P10636-8 MAPT human T181 447932 ktPPAPktPPssGEP X X 12885; 66224; 62672 -GSK3B GSK3B P49841 human ULK1 22241 O70405 Ulk1 mouse S405 23070960 HGRTPsPsPTCSSSP X -GSK3B GSK3B P49841 human Myb 17863 P06876 Myb mouse T572 1308922 LTSSVLMtPVSEDED X X -GSK3B GSK3B P49841 human DRP1 10059 O00429 DNM1L human S616 454690 PIPIMPAsPQKGHAV X 3455; 4494; 63940 -GSK3B GSK3B P49841 human PICK1 9463 Q9NRD5 PICK1 human S415 50642302 kGGsWCDs_______ X -GSK3B GSK3B P49841 human CLASP2 23122 O75122 CLASP2 human S533 22349885 QGCsREAsREssRDT X X -GSK3B GSK3B P49841 human ZAP 252832 Q8K3Y6 Zc3hav1 rat S283 483725 DVTsCKDsLEDVsVD X -GSK3B GSK3B P49841 human neurogenin 2 11924 P70447 Neurog2 mouse S234 2255100 SCTLsPAsPGSDVDy X -GSK3B GSK3B P49841 human TBK1 29110 Q9UHD2 TBK1 human S172 447732 EDDEQFVsLyGTEEy Pkinase X 5483; 13498; 14590; 14586; 54382; 70483; 20399 -GSK3B GSK3B P49841 human GRB14 2888 Q14449 GRB14 human S419 24986639 LRLGTHGsPtAsSQS X -GSK3B GSK3B P49841 human RAB11FIP5 26056 Q9BXF6 RAB11FIP5 human S188 4957683 sMKDKPRsPFsKIRD X -GSK3B GSK3B P49841 human CCNE1 898 P24864 CCNE1 human T395 447676 PLPSGLLtPPQsGKK X X -GSK3B GSK3B P49841 human GR 2908 P04150 NR3C1 human S404 5044100 SMRPDVSsPPSSSST X X -GSK3B GSK3B P49841 human MCL1 4170 Q07820 MCL1 human T163 455375 tDGsLPstPPPAEEE X 4579; 14765 -GSK3B GSK3B P49841 human GYS1 100008660 P13834 GYS1 rabbit S649 448239 VPPsPSLsRHSsPHQ Glycogen_syn X -GSK3B GSK3B P49841 human 4E-BP1 1978 Q13541 EIF4EBP1 human T37 447497 PPGDysttPGGtLFs eIF_4EBP X X 2855; 9459; 2846; 5123; 3929; 7547; 45613; 39788 -GSK3B GSK3B P49841 human HSF1 3297 Q00613 HSF1 human S303 449045 RVkEEPPsPPQsPRV Vert_HS_TF X -GSK3B GSK3B P49841 human Tau iso8 4137 P10636-8 MAPT human T175 449077 AtRIPAktPPAPktP X -GSK3B GSK3B P49841 human TRAF6 7189 Q9Y4K3 TRAF6 human T266 1867864101 ARHLQENtQSHMRML X -GSK3B GSK3B P49841 human Bcl-2L12 83596 Q9HB09 BCL2L12 human S156 9258022 SESPRPCsLPIRPCY X X -GSK3B GSK3B P49841 human TUSC5 237858 Q8C838 Trarg1 mouse S76 7829266 PsLsGsPsRVssRRA X -GSK3B GSK3B P49841 human MAP1B 17755 P14873 Map1b mouse S1260 454136 sLsPsPPsPIEKtPL X X -GSK3B GSK3B P49841 human OSBP2 23762 Q969R2 OSBP2 human S768 15721697 HssPssPsSDGKQKT Oxysterol_BP X -GSK3B GSK3B P49841 human HRas 3265 P01112 HRAS human S183 25324401 ESGPGCMsCKCVLS_ X -GSK3B GSK3B P49841 human ACF7 23499 Q9UPN3 MACF1 human S7326 18507011 RAGsRAssRRGsDAs X X -GSK3B GSK3B P49841 human NDEL1 83431 Q9ERR1 Ndel1 mouse S332 1869686802 PPPGLGSsRPSsAPG X -GSK3B GSK3B P49841 human CRMP-2 25416 P47942 Dpysl2 rat S518 448081 KTVtPASsAKTsPAK X -GSK3B GSK3B P49841 human ZNF322A 79692 Q6U7Q0 ZNF322 human S391 31086030 SEKGLELsPPHAsEA X -GSK3B GSK3B P49841 human Snail1 6615 O95863 SNAI1 human S96 455883 TsLsDEDsGkGsQPP X X -GSK3B GSK3B P49841 human Myc 4609 P01106 MYC human S77 448586 LLPtPPLsPsRRsGL Myc_N X 13748 -GSK3B GSK3B P49841 human ADD2 119 P35612 ADD2 human S613 3147399 AKEAEtKsPLVsPsK X -GSK3B GSK3B P49841 human GYS1 100008660 P13834 GYS1 rabbit S641 448237 YRYPRPAsVPPsPSL Glycogen_syn X -GSK3B GSK3B P49841 human ACBD5 iso2 91452 Q5T8D3-2 ACBD5 human S269 34501844 DsEVYCDsMEQFGQE X X -GSK3B GSK3B P49841 human SOX4 20677 Q06831 Sox4 mouse S316 41454646 GRSSAAssPAASRSP X -GSK3B GSK3B P49841 human Tip60 10524 Q92993 KAT5 human S90 448827 LPGsRPGsPEREVPA X X -GSK3B GSK3B P49841 human RXRA 6256 P19793 RXRA human S66 333674900 NGMGPPFsVISSPMG Nuc_recep-AF1 X -GSK3B GSK3B P49841 human CTNNB1 1499 P35222 CTNNB1 human S33 447487 QQQsyLDsGIHsGAT X X 9561; 2009; 4270; 13537; 41334; 60180 -GSK3B GSK3B P49841 human APC 324 P25054 APC human S1503 999607 TPDGFsCsssLsALs APC_r X -GSK3B GSK3B P49841 human ZAP 252832 Q8K3Y6 Zc3hav1 rat S266 4776621 EFLsPVVsPLGsGPP X X -GSK3B GSK3B P49841 human MITF iso9 4286 O75030-9 MITF human S397 11126131 DPLLSSVsPGAsKTS DUF3371 X -GSK3B GSK3B P49841 human MARK2 60328 O08679 Mark2 rat S212 450068 KLDtFCGsPPYAAPE Pkinase X -GSK3B GSK3B P49841 human AHR 196 P35869 AHR human S436 1874101916 LRTKNGTsGkDsATT X -GSK3B GSK3B P49841 human PU.1 6688 P17947 SPI1 human S140 451055 EEEGERQsPPLEVsD X X -GSK3B GSK3B P49841 human Wee1 7465 P30291 WEE1 human S211 25316773 SSVkLRGssLFMDtE X -GSK3B GSK3B P49841 human PHLPP 23239 O60346 PHLPP1 human S1359 22769300 VPRPHVQsVLLtPQD PP2C X X -GSK3B GSK3B P49841 human Tau iso8 4137 P10636-8 MAPT human T212 447934 tPGsRsRtPsLPtPP X X -GSK3B GSK3B P49841 human IRF1 16362 P15314 Irf1 mouse S185 1380568701 RDItPALsPCVVSSS X -GSK3B GSK3B P49841 human EB1 22919 Q15691 MAPRE1 human S155 476322 kPkkPLtssSAAPQR X -GSK3B GSK3B P49841 human SSH2 237860 Q5SW75 Ssh2 mouse S32 22775200 sGEEECRsQPRsIsE X X -GSK3B GSK3B P49841 human myocardin 214384 Q8VIM5 Myocd mouse S636 3627511 PQCsPQHsPLGGLKS X X -GSK3B GSK3B P49841 human ataxin-3 4287 P54252 ATXN3 human S256 479405 LRRAIQLsMQGsSRN UIM X -GSK3B GSK3B P49841 human CABYR 26256 O75952 CABYR human S155 11454100 KTTtPPSsPPPTAVS X -GSK3B GSK3B P49841 human myocardin 214384 Q8VIM5 Myocd mouse S632 3627509 TFLsPQCsPQHsPLG X X -GSK3B GSK3B P49841 human OSBP2 23762 Q969R2 OSBP2 human S763 31727226 CSKVMHssPssPsSD Oxysterol_BP X -GSK3B GSK3B P49841 human NFkB-p100 4791 Q00653 NFKB2 human S222 3193889 QPIHDSKsPGASNLk X X -GSK3B GSK3B P49841 human GFI1 2672 Q99684 GFI1 human S98 1868711303 RPPsPSAsPASEKSM X X -GSK3B GSK3B P49841 human EZH2 2146 Q15910 EZH2 human S363 466986 GRLPNNssRPstPtI X X -GSK3B GSK3B P49841 human SNCAIP 9627 Q9Y6H5 SNCAIP human S556 469990 AQKSEGKsLPssPss SNCAIP_SNCA_bd X X -GSK3B GSK3B P49841 human AHR 196 P35869 AHR human S689 1874101922 SQEFPYKsEMDsMPY X -GSK3B GSK3B P49841 human IRF1 3659 P10914 IRF1 human S184 1380568701 QALtPALsPCAVSST X -GSK3B GSK3B P49841 human MEF2D 81518 O89038 Mef2d rat T145 10359101 PNFAMPVtVPVsNQS HJURP_C X X -GSK3B GSK3B P49841 human NFkB-p100 4791 Q00653 NFKB2 human S707 20804978 EPLCPLPsPPTsDsD X X -GSK3B GSK3B P49841 human Snail1 6615 O95863 SNAI1 human S115 6097707 PAPssFSsTSVsSLE X X -GSK3B GSK3B P49841 human RAPH1 65059 Q70E73 RAPH1 human S1066 23137493 DsVVEFPsPPsDsDF X -GSK3B GSK3B P49841 human CLASP2 23122 O75122 CLASP2 human S503 22349881 IPRsQGCsREAsPsR X -GSK3B GSK3B P49841 human CTNNB1 1499 P35222 CTNNB1 human T41 447583 GIHsGATtTAPsLsG X X 9561; 9565; 4270; 13537; 41334; 60180 -GSK3B GSK3B P49841 human DRP1 10059 O00429 DNM1L human S693 27276100 LVGQLYKsSLLDDLL GED X X -GSK3B GSK3B P49841 human VHL 7428 P40337 VHL human S68 469116 PVLRSVNsREPsQVI VHL X -GSK3B GSK3B P49841 human MAFA 378435 Q8CF90 Mafa mouse T57 456028 LSStPLStPCSsVPS X -GSK3B GSK3B P49841 human MNX1 15285 Q9QZW9 Mnx1 mouse S80 3191344 RLRAEsPsPPRLLAA X X -GSK3B GSK3B P49841 human MAP2 iso3 25595 P15146-3 Map2 rat T262 450182 RTPGtPGtPSYPRTP X -GSK3B GSK3B P49841 human Src 6714 P12931 SRC human S493 1871762502 CPPECPEsLHDLMCQ PK_Tyr_Ser-Thr X -GSK3B GSK3B P49841 human CCND2 894 P30279 CCND2 human T280 469202 DELDQAstPtDVRDI Cyclin_C X X -GSK3B GSK3B P49841 human RICTOR 253260 Q6R327 RICTOR human S1235 458282 GIssMSssPSRETVG X -GSK3B GSK3B P49841 human Snail2 6591 O43623 SNAI2 human S92 25603910 RVsPPPPsDTSsKDH X X -GSK3B GSK3B P49841 human VDAC1 7416 P21796 VDAC1 human S13 479874 TYADLGksARDVFtk Porin_3 X -GSK3B GSK3B P49841 human SOX11 20666 Q7M6Y2 Sox11 mouse S289 50800237 PPAPPALsPASSRCV X -GSK3B GSK3B P49841 human PPAR-alpha 19013 P23204 Ppara mouse S73 59026900 SVITDTLsPASSPSS X -GSK3B GSK3B P49841 human Desmoplakin 1832 P15924 DSP human S2849 451165 RsGsRRGsFDAtGNs X -GSK3B GSK3B P49841 human FOXM1 iso2 2305 Q08050-2 FOXM1 human S474 22648002 PPLEEWPsPAPSFkE X -GSK3B GSK3B P49841 human GLE1 2733 Q53GS7 GLE1 human S93 31084897 PKsPDAssAFsPAsP X -GSK3B GSK3B P49841 human NFH 24587 P16884 Nefh rat S493 455548 GEEAATTsPPAEEAA X -GSK3B GSK3B P49841 human PPP1R2 5504 P41236 PPP1R2 human T73 449051 MKIDEPstPyHSMMG IPP-2 X X -GSK3B GSK3B P49841 human PHLPP 23239 O60346 PHLPP1 human S1381 22769301 KGLWDsLsVEEAVEA PP2C X -GSK3B GSK3B P49841 human 4E-BP1 1978 Q13541 EIF4EBP1 human T46 447496 GGtLFsttPGGtRII eIF_4EBP X X 2855; 9459; 2846; 4923; 5123; 3929; 7547; 45613; 39788 -GSK3B GSK3B P49841 human CTNND1 12388 P30999 Ctnnd1 mouse S252 450456 MEGyRAPsRQDVyGP X 8477 -GSK3B GSK3B P49841 human AHR 196 P35869 AHR human T731 1874101932 FEPsPYPtTSSLEDF X -GSK3B GSK3B P49841 human SPAG5 10615 Q96R06 SPAG5 human T937 460416 ADEEPEStPVPLLGs X X -GSK3B GSK3B P49841 human MEF2D 81518 O89038 Mef2d rat S149 10359103 MPVtVPVsNQSsMQF HJURP_C X X -GSK3B GSK3B P49841 human EIF6 3692 P56537 EIF6 human S239 3193264 IAtsMRDsLIDsLt_ X -GSK3B GSK3B P49841 human Src 6714 P12931 SRC human Y419 448234 RLIEDNEytARQGAk PK_Tyr_Ser-Thr X X 2101; 6943; 59548; 70926; 78740; 94361; 17320 -GSK3B GSK3B P49841 human C/EBP-delta 1052 P49716 CEBPD human S167 28852500 SPEPPRSsPRQtPAP X X -GSK3B GSK3B P49841 human NIFK 84365 Q9BYG3 NIFK human T234 449332 tVDsQGPtPVCtPtF hNIFK_binding X -GSK3B GSK3B P49841 human CCNE1 898 P24864 CCNE1 human T77 454411 DPCsLIPtPDKEDDD X 4136 -GSK3B GSK3B P49841 human Ets-1 2113 P14921 ETS1 human T265 31087093 yDsCDRLtQsWssQs Ets1_N_flank X -GSK3B GSK3B P49841 human Myc 17869 P01108 Myc mouse T73 448496 KKFELLPtPPLsPsR Myc_N X 46650 -GSK3B GSK3B P49841 human NRF2 4780 Q16236 NFE2L2 human S344 18258505 AEFNDSDsGIsLNTs X X -GSK3B GSK3B P49841 human GYS1 2997 P13807 GYS1 human S645 448238 RPAsVPPsPsLsRHs Glycogen_syn X -GSK3B GSK3B P49841 human NFE2L1 4779 Q14494 NFE2L1 human S379 27971902 SQDFLLFsPEVESLP X X -GSK3B GSK3B P49841 human GLE1 2733 Q53GS7 GLE1 human S92 50831365 VPKsPDAssAFsPAs X -GSK3B GSK3B P49841 human EZH2 2146 Q15910 EZH2 human T367 466987 NNssRPstPtINVLE X X -GSK3B GSK3B P49841 human Tau iso8 4137 P10636-8 MAPT human T205 447933 ssPGsPGtPGsRsRt X X 25377; 43964; 53001; 49561; 20060; 33032; 30505; 20739; 98160 -GSK3B GSK3B P49841 human TUSC5 237858 Q8C838 Trarg1 mouse S80 3842521 GsPsRVssRRAssVI X -GSK3B GSK3B P49841 human FBXL20 84961 Q96IG2 FBXL20 human S421 467840 APVtPPPsVGGsRQR X X -GSK3B GSK3B P49841 human MARK2 2011 Q7KZI7 MARK2 human S212 450068 KLDtFCGsPPYAAPE Pkinase X -GSK3B GSK3B P49841 human NFAT1 18019 Q60591 Nfatc2 mouse S219 447846 AHYsPRtsPIMsPRT X -GSK3B GSK3B P49841 human KLF5 688 Q13887 KLF5 human S303 14652801 QATYFPPsPPSSEPG X X -GSK3B GSK3B P49841 human GRB14 2888 Q14449 GRB14 human S366 29576856 GCSsQSIsPMRsIsE X X -GSK3B GSK3B P49841 human CRMP-4 1809 Q14195 DPYSL3 human T509 454328 PVFDLtttPkGGtPA X X -GSK3B GSK3B P49841 human SERT 6532 P31645 SLC6A4 human S48 1869992415 GQISNGysAVPSPGA 5HT_transport_N X -GSK3B GSK3B P49841 human IRF1 3659 P10914 IRF1 human T180 1380568700 LEVEQALtPALsPCA X -GSK3B GSK3B P49841 human Tau iso8 4137 P10636-8 MAPT human S422 449083 GsIDMVDsPQLAtLA X X -GSK3B GSK3B P49841 human RXRA 6256 P19793 RXRA human S78 333674902 PMGPHSMsVPTtPTL Nuc_recep-AF1 X -GSK3B GSK3B P49841 human PD-L1 29126 Q9NZQ7 CD274 human T180 63237406 QVLSGkTtTTNsKRE C2-set_2 X X -GSK3B GSK3B P49841 human USF2 7392 Q15853 USF2 human S155 36392500 NPFSNGGsPAAEAVS X X -GSK3B GSK3B P49841 human Tau iso8 4137 P10636-8 MAPT human S235 449080 VVRtPPKsPssAKsR X 20473 -GSK3B GSK3B P49841 human GLE1 2733 Q53GS7 GLE1 human S88 12667856 QPSFVPKsPDAssAF X -GSK3B GSK3B P49841 human ENDOG 2021 Q14249 ENDOG human T128 1871762501 VHAYHRAtNADYRGS Endonuclease_NS X X -GSK3B GSK3B P49841 human IRF3 3661 Q14653 IRF3 human S173 6370303 PCPQPLRsPsLDNPt X X -GSK3B GSK3B P49841 human p21Cip1 1026 P38936 CDKN1A human T57 451222 NFDFVtEtPLEGDFA CDI X -GSK3B GSK3B P49841 human SSH2 237860 Q5SW75 Ssh2 mouse S21 17544228 TTSsPCAsEADsGEE X X -GSK3B GSK3B P49841 human CRMP-4 1809 Q14195 DPYSL3 human S518 458799 kGGtPAGsArGsPtR X X -GSK3B GSK3B P49841 human AHR 196 P35869 AHR human S693 1874101924 PYKsEMDsMPYtQNF X -GSK3B GSK3B P49841 human gephyrin 268566 Q8BUV3 Gphn mouse S270 2020113 LsttPsEsPRAQATs X -GSK3B GSK3B P49841 human RBM38 56190 Q62176 Rbm38 mouse S193 29606707 DQYPYAAsPAAATSF X -GSK3B GSK3B P49841 human TRAF4AF1 90417 Q9Y448 KNSTRN human T294 1876350206 VRFLEQQtLCNNQVN X X -GSK3B GSK3B P49841 human Raptor 57521 Q8N122 RPTOR human S722 2314601 PrLrsVssyGNIRAV X -GSK3B GSK3B P49841 human MLK3 4296 Q16584 MAP3K11 human S793 448613 PRPsPLPsPQPAPRR X X -GSK3B GSK3B P49841 human IKKG 8517 Q9Y6K9 IKBKG human S17 50564412 LCEMVQPsGGPAADQ X X -GSK3B GSK3B P49841 human HDAC4 9759 P56524 HDAC4 human S298 1322400 ACSSAPGsGPSsPNN X X -GSK3B GSK3B P49841 human Tau iso8 4137 P10636-8 MAPT human S210 487450 PGtPGsRsRtPsLPt X -GSK3B GSK3B P49841 human AREL1 iso2 9870 O15033-2 AREL1 human T783 56589716 IAAPTHStLPTAHT_ HECT X X -GSK3B GSK3B P49841 human CRMP-2 25416 P47942 Dpysl2 rat T509 448083 PVCEVSVtPKTVtPA X X -GSK3B GSK3B P49841 human CAP1 10487 Q01518 CAP1 human S308 485063 sAPKPQtsPsPkRAt X -GSK3B GSK3B P49841 human Securin 9232 O95997 PTTG1 human S183 20764101 SNLLQSPssILSTLD Securin X X -GSK3B GSK3B P49841 human C/EBP-beta 24253 P21272 Cebpb rat S185 455886 LSTsSSSsPPGtPSP X X -GSK3B GSK3B P49841 human CTNND1 12388 P30999 Ctnnd1 mouse T310 450457 GtARRtGtPsDPRRR X -GSK3B GSK3B P49841 human BORA 79866 Q6PGQ7 BORA human S274 9318308 TSPsPISsPTFsPIE X X -GSK3B GSK3B P49841 human MYBPC3 4607 Q14896 MYBPC3 human S133 27463600 ELGESAPsPKGSSSA X -GSK3B GSK3B P49841 human TRIM72 493829 Q6ZMU5 TRIM72 human S255 27461213 LQKILAEsPPPARLD X X -GSK3B GSK3B P49841 human SIGIRR 59307 Q6IA17 SIGIRR human T372 1873759800 EPSAPPHtSGVSLGE X -GSK3B GSK3B P49841 human ACF7 23499 Q9UPN3 MACF1 human S7310 18507009 ADPKKSAsRPGsRAG X X -GSK3B GSK3B P49841 human PPIF 10105 P30405 PPIF human S191 27460203 IEsFGsksGRTSKKI Pro_isomerase X -GSK3B GSK3B P49841 human EGLN2 112398 Q96KS0 EGLN2 human T405 50777944 VPVsQPPtPT_____ X -GSK3B GSK3B P49841 human NACA 4666 E9PAV3 NACA human T2022 451197 NIQENtQtPtVQEEs X X -GSK3B GSK3B P49841 human Snail1 6615 O95863 SNAI1 human S111 6097705 sPPsPAPssFSsTSV X X -GSK3B GSK3B P49841 human Telethonin 8557 O15273 TCAP human S161 3893741 RsLsRSMsQEAQRG_ Telethonin X -MAPKAPK3 MAPKAPK3 Q16644 human TAB3 257397 Q8N5C8 TAB3 human S506 1295507 HKYQRsSsSGSDDyA X -MAPKAPK3 MAPKAPK3 Q16644 human beclin 1 8678 Q14457 BECN1 human S90 472001 IPPARMMstEsANsF X 29362; 86455 -MAPKAPK3 MAPKAPK3 Q16644 human HSP27 3315 P04792 HSPB1 human S82 448403 RALsRQLssGVsEIr X 2406; 2401; 9709; 11892; 64293 -Ikbkb IKKB O88351 mouse IkB-alpha 18035 Q9Z1E3 Nfkbia mouse S32 448203 LVDDRHDsGLDsMKD X X 5210; 2859; 9246; 5209 -Ikbkb IKKB O88351 mouse NFkB-p105 18033 P25799 Nfkb1 mouse S935 447771 CDSGVETsFRKLsFt X X 4806; 4808; 41317 -Ikbkb IKKB O88351 mouse IKKB 16150 O88351 Ikbkb mouse S181 447489 DQGsLCTsFVGTLQy Pkinase X 2697; 2694; 14938; 92255; 36516; 36214 -Ikbkb IKKB O88351 mouse IKKB 16150 O88351 Ikbkb mouse S701 17934904 ACDsLPEsDKKsEEL X -Ikbkb IKKB O88351 mouse XBP1 22433 O35426 Xbp1 mouse S148 63075900 PEVEAKGsGVRLVAG X -Ikbkb IKKB O88351 mouse IKKB 16150 O88351 Ikbkb mouse S705 17934902 LPEsDKKsEELVAEA X -Ikbkb IKKB O88351 mouse SNAP23 20619 O09044 Snap23 mouse S95 455262 NRTkNFEsGKNYkAt SNAP-25 X -Ikbkb IKKB O88351 mouse IKKB 16150 O88351 Ikbkb mouse S679 5735027 sPDsMNVsRLsHPGQ X -Ikbkb IKKB O88351 mouse IKKB 16150 O88351 Ikbkb mouse S689 3676802 sHPGQLMsQPsSACD X -Ikbkb IKKB O88351 mouse IKKB 16150 O88351 Ikbkb mouse S697 17934903 QPsSACDsLPEsDKK X -Ikbkb IKKB O88351 mouse IkB-alpha 18035 Q9Z1E3 Nfkbia mouse S36 448204 RHDsGLDsMKDEEYE X X 5210; 9246 -Ikbkb IKKB O88351 mouse Cot 26410 Q07174 Map3k8 mouse T290 455276 LPKDLRGtEIYMSPE Pkinase X -Ikbkb IKKB O88351 mouse IKKB 16150 O88351 Ikbkb mouse S682 17934901 sMNVsRLsHPGQLMs X -Ikbkb IKKB O88351 mouse XBP1 22433 O35426 Xbp1 mouse T48 21688103 AGSEASGtPQARKRQ X -Ikbkb IKKB O88351 mouse SNAP23 20619 O09044 Snap23 mouse S120 455263 NVVskQPsRITNGQP SNAP-25 X -Ikbkb IKKB O88351 mouse NFkB-p65 19697 Q04207 Rela mouse S534 447800 sGDEDFssIADMDFS X X 4887; 3036; 3031; 4886; 3033; 4025; 5733; 13346; 76778; 31553; 80477; 73992; 87672; 83962 -Ikbkb IKKB O88351 mouse IKKB 16150 O88351 Ikbkb mouse S692 5735033 GQLMsQPsSACDsLP X -Ikbkb IKKB O88351 mouse BAD 12015 Q61337 Bad mouse S26 27530804 KsDPGIRsLGSDAGG X X -SBK1 SBK Q52WX2 human Nur77 15370 P12813 Nr4a1 mouse S344 451513 KEVVRTDsLKGRRGR X X -BMX Etk P51813 human FAK 5747 Q05397 PTK2 human Y925 447966 DRsNDkVyENVtGLV Focal_AT X 3284 -BMX Etk P51813 human FGFR1 2260 P11362 FGFR1 human Y653 447918 RDIHHIDyykKTTNG PK_Tyr_Ser-Thr X 3471; 3476; 52928 -BMX Etk P51813 human Ack 10188 Q07912 TNK2 human Y860 448884 KVsstHyyLLPERPs X -BMX Etk P51813 human BAK1 578 Q16611 BAK1 human Y108 15794303 QPTAENAyEyFTkIA Bcl-2 X X -BMX Etk P51813 human FAK 5747 Q05397 PTK2 human Y577 447890 yMEDstyyKAsKGKL PK_Tyr_Ser-Thr X X 3281 -BMX Etk P51813 human FAK 5747 Q05397 PTK2 human Y1007 2867002 kMKLAQQyVMTSLQQ Focal_AT X -BMX Etk P51813 human PAK1 5058 Q13153 PAK1 human Y153 463955 tDksAEDyNssNALN X -BMX Etk P51813 human FAK 5747 Q05397 PTK2 human Y898 485796 LSsPADSyNEGVKLQ X -BMX Etk P51813 human Ack 10188 Q07912 TNK2 human Y859 448883 KKVsstHyyLLPERP X -BMX Etk P51813 human RUFY1 80230 Q96T51 RUFY1 human Y400 451278 RQGLDEMysDVWKQL X -BMX Etk P51813 human FAK 5747 Q05397 PTK2 human Y742 6153381 HMVQTNHyQVSGYPG X -BMX Etk P51813 human FGFR1 2260 P11362 FGFR1 human Y654 447919 DIHHIDyykKTTNGR PK_Tyr_Ser-Thr X 3471; 3476; 52928 -BMX Etk P51813 human FAK 5747 Q05397 PTK2 human Y861 447965 PIGNQHIyQPVGKPD X -BMX Etk P51813 human P130Cas 9564 P56945 BCAR1 human Y12 4251353 NVLAKALyDNVAEsP SH3_1 X -BMX Etk P51813 human FAK 5747 Q05397 PTK2 human Y441 462051 GDVHQGIyMsPENPA PK_Tyr_Ser-Thr X -BMX Etk P51813 human FAK 5747 Q05397 PTK2 human Y194 18122800 ALEKKSNyEVLEkDV FERM_M X -BMX Etk P51813 human RUFY1 80230 Q96T51 RUFY1 human Y389 451277 TKVELETykQTRQGL X -BMX Etk P51813 human FAK 5747 Q05397 PTK2 human Y576 447889 RyMEDstyyKAsKGK PK_Tyr_Ser-Thr X 3281 -BMX Etk P51813 human Met 4233 P08581 MET human Y1235 448471 DMyDkEyysVHNktG PK_Tyr_Ser-Thr X 4091; 3129; 3126; 3077; 12468; 4033; 98954 -PLK2 PLK2 Q9NYY3 human CRYAB 1410 P02511 CRYAB human S19 447728 RPFFPFHsPsrLFDQ Crystallin X -PLK2 PLK2 Q9NYY3 human 14-3-3 epsilon 7531 P62258 YWHAE human T208 14569209 DAIAELDtLsEEsyk 14-3-3 X -PLK2 PLK2 Q9NYY3 human CALU 813 O43852 CALU human S44 4274908 kVHNDAQsFDyDHDA X -PLK2 PLK2 Q9NYY3 human CENPJ 55835 Q9HC77 CENPJ human S595 14918201 IsFSSNSsFVLKILE X X -PLK2 PLK2 Q9NYY3 human FBXW7 55294 Q969H0 FBXW7 human S349 25126711 IKPGFIHsPWKSAYI X -PLK2 PLK2 Q9NYY3 human CALU 813 O43852 CALU human T60 25688700 LGAEEAktFDQLtPE X -PLK2 PLK2 Q9NYY3 human SNCB 6620 Q16143 SNCB human S118 448525 LMEPEGEsYEDPPQE Synuclein X -PLK2 PLK2 Q9NYY3 human PLK1 5347 P53350 PLK1 human S137 448138 LELCRRRsLLELHkR Pkinase X X -PLK2 PLK2 Q9NYY3 human TACE 11491 Q9Z0F8 Adam17 mouse S794 449040 NsSTAAKsFEDLTDH X -PLK2 PLK2 Q9NYY3 human SNCA 6622 P37840 SNCA human S129 448278 NEAyEMPsEEGyQDy Synuclein X X 23706; 87281 -PLK2 PLK2 Q9NYY3 human CENPJ 55835 Q9HC77 CENPJ human S589 14918202 EQAADEIsFSSNSsF X X -PLK2 PLK2 Q9NYY3 human p73 7161 O15350 TP73 human S48 52434701 VVGGTDssMDVFHLE X X -PLK2 PLK2 Q9NYY3 human NRF2 83619 O54968 Nfe2l2 rat S40 450082 SREVFDFsQRQKDYE X X -PLK2 PLK2 Q9NYY3 human CALU 813 O43852 CALU human T196 25688702 KDIVVQEtMEDIDKN EF-hand_5 X -PLK2 PLK2 Q9NYY3 human NPM1 4869 P06748 NPM1 human S4 452023 ____MEDsMDMDMsP X X 3520 -PLK2 PLK2 Q9NYY3 human FBXW7 55294 Q969H0 FBXW7 human S176 25126709 KRKLDHGsEVRSFSL X X -PLK2 PLK2 Q9NYY3 human FBXW7 55294 Q969H0 FBXW7 human S25 25126710 sLRGNPSssQVDEEQ X -ARAF ARAF P10398 human MEK1 5604 Q02750 MAP2K1 human S222 448513 LIDsMANsFVGtRSY Pkinase X X 2338; 9121; 3958; 9154; 16211; 86128; 16780; 75262 -ARAF ARAF P10398 human MEK1 5604 Q02750 MAP2K1 human S218 448514 VsGQLIDsMANsFVG Pkinase X X 9121; 3958; 9154; 86128 -ARAF ARAF P10398 human BAD 572 Q92934 BAD human S99 447862 PFrGrsRsAPPNLWA Bcl-2_BAD X 9295; 5286; 4366 -ARAF ARAF P10398 human BAD 572 Q92934 BAD human S75 447860 EIRsRHssyPAGtED Bcl-2_BAD X 9291; 5284; 9296; 5193; 11865; 94223 -ARAF ARAF P10398 human NHERF-2 9351 Q15599 NHERF2 human S303 9765067 QEsGLHLsPtAAEAK EBP50_C X -ARAF ARAF P10398 human BAD 572 Q92934 BAD human S118 447863 GRELRRMsDEFVDsF Bcl-2_BAD X 9297 -Mapk1 ERK2 P63085 mouse IRS1 16367 P35569 Irs1 mouse S612 447562 DDGyMPMsPGVAPVP X 3193; 2386; 3203 -Mapk1 ERK2 P63085 mouse TNRC15 227331 Q6Y7W8 Gigyf2 mouse S30 483131 sItsPPLsPALPKYK X -Mapk1 ERK2 P63085 mouse GATA1 14460 P17679 Gata1 mouse S26 451232 VDSALVSsPSDSTGF X -Mapk1 ERK2 P63085 mouse FOXO1A 56458 Q9R1E0 Foxo1 mouse S475 478372 PPHNDIMsPVDPGVA FOXO_KIX_bdg X X -Mapk1 ERK2 P63085 mouse hnRNP H1 59013 O35737 Hnrnph1 mouse S104 455395 LKHtGPNsPDtANDG X -Mapk1 ERK2 P63085 mouse SNX2 67804 Q9CWK8 Snx2 mouse T104 4774054 sPAVtPVtPttLIAP X -Mapk1 ERK2 P63085 mouse CEP170 545389 Q6A065 Cep170 mouse T562 21686704 EERKPLStPGFHNsE X -Mapk1 ERK2 P63085 mouse FOXO1A 56458 Q9R1E0 Foxo1 mouse S326 448076 stISGRLsPIMtEQD X -Mapk1 ERK2 P63085 mouse GJA1 24392 P08050 Gja1 rat S282 448854 TAPLsPMsPPGYkLV X -Mapk1 ERK2 P63085 mouse FAM65A 75687 Q68FE6 Ripor1 mouse T351 467861 YsQsPPDtPSLREQA PL48 X -Mapk1 ERK2 P63085 mouse BIM 12125 O54918 Bcl2l11 mouse S55 454235 GDRCPHGsPQGPLAP X 4550 -Mapk1 ERK2 P63085 mouse GJA1 14609 P23242 Gja1 mouse S282 448854 tAPLsPMsPPGykLV X -Mapk1 ERK2 P63085 mouse DENND4C 329877 A6H8H2 Dennd4c mouse S1221 3202029 DSEDKLFsPVISRNL X -Mapk1 ERK2 P63085 mouse Spinophilin 217124 Q6R891 Ppp1r9b mouse S205 455382 KLDADAVsPTVSQLs X -Mapk1 ERK2 P63085 mouse PHLDB1 102693 Q6PDH0 Phldb1 mouse S463 7103243 MRELPPLsPsLsRRA X -Mapk1 ERK2 P63085 mouse PHF2 18676 Q9WTU0 Phf2 mouse S651 3175945 KALRPPssPGVFGAL X -Mapk1 ERK2 P63085 mouse NIPA 232679 Q80YV2 Zc3hc1 mouse S353 449745 PIVsRtRsWEsssPV X -Mapk1 ERK2 P63085 mouse MAP1A 17754 Q9QYR6 Map1a mouse T1806 471459 PtRNEPttPSWLAEI X -Mapk1 ERK2 P63085 mouse ERK2 26413 P63085 Mapk1 mouse Y185 447594 HtGFLtEyVAtRWYR Pkinase X 9106; 4370; 4374; 9101; 4375; 4376; 4377; 3510; 5726; 88569; 13214; 13148; 70235; 9488; 89967; 8544; 14196; 14227; 14095; 14474; 75165; 98168; 33370; 54240; 15892; 45899; 55088; 9524; 69217; 48735 -Mapk1 ERK2 P63085 mouse NG2 81651 Q00657 Cspg4 rat T2314 483998 ELLQFCRtPNPALRN X -Mapk1 ERK2 P63085 mouse FRA2 14284 P47930 Fosl2 mouse T322 14573760 SDSLNsPtLLAL___ X -Mapk1 ERK2 P63085 mouse Kv7.2 3785 O43526 KCNQ2 human S476 481668 ADQSLEDsPSKVPKS KCNQ_channel X X -Mapk1 ERK2 P63085 mouse KSR 16706 Q61097 Ksr1 mouse T274 449299 AKLKPPRtPPPPsRK X X -Mapk1 ERK2 P63085 mouse SSBP3 72475 Q9D032 Ssbp3 mouse T360 469908 GIsNPPGtPRDDGEL SSDP X -Mapk1 ERK2 P63085 mouse Hic-5 21804 Q62219 Tgfb1i1 mouse S141 472323 SSPTVPPsPFPAPSK X -Mapk1 ERK2 P63085 mouse TNKS1BP1 228140 P58871 Tnks1bp1 mouse T131 3827252 KEDLPPLtPPARCAA X -Mapk1 ERK2 P63085 mouse ETV1 14009 P41164 Etv1 mouse S146 3059603 tPSStPVsPLHHASP ETS_PEA3_N X -Mapk1 ERK2 P63085 mouse DYNC1I2 13427 O88487 Dync1i2 mouse S81 449148 PIVPPPMsPssKsVs X -Mapk1 ERK2 P63085 mouse GATA6 14465 Q61169 Gata6 mouse S264 2833503 ASARFPYsPSPPMAN GATA-N X -Mapk1 ERK2 P63085 mouse AHNAK2 iso2 100041194 Q3URZ6 Ahnak2 mouse T510 15417563 IPASTIQtPSYGFSL X -Mapk1 ERK2 P63085 mouse NG2 81651 Q00657 Cspg4 rat T2265 9641600 KHDVQVLtAKPRNGL X -Mapk1 ERK2 P63085 mouse AHNAK 66395 E9Q616 Ahnak mouse S4879 3148491 DVEFDIKsPKFKAEA X -Mapk1 ERK2 P63085 mouse BAT2 53761 Q7TSC1 Prrc2a mouse S1002 467535 tPPGGNLsPAPRLRR X -Mapk1 ERK2 P63085 mouse 53BP2 209456 Q8CG79 Trp53bp2 mouse T585 15401906 AAAVRPFtPQPSKDT X -Mapk1 ERK2 P63085 mouse FRA2 14284 P47930 Fosl2 mouse S200 452624 ISPEERRsPPtsGLQ X -Mapk1 ERK2 P63085 mouse SAFB2 224902 Q80YR5 Safb2 mouse S387 454341 RAPtAALsPEPQDsK X -Mapk1 ERK2 P63085 mouse Nidogen-1 18073 P10493 Nid1 mouse S331 21686714 HNVPRILsPGYEATE X -Mapk1 ERK2 P63085 mouse PDXDC1 94184 Q99K01 Pdxdc1 mouse T691 485769 tGVtPPPtPLGtRSK X -Mapk1 ERK2 P63085 mouse TNKS1BP1 228140 P58871 Tnks1bp1 mouse T1025 3211752 GGLLsPstPHsRDGA X -Mapk1 ERK2 P63085 mouse FOXO1A 56458 Q9R1E0 Foxo1 mouse S429 478370 TYGQSSMsPLPQMPM FOXO_KIX_bdg X X -Mapk1 ERK2 P63085 mouse AEBP1 11568 Q640N1 Aebp1 mouse T1003 455321 VDPSRPMtPQQRRMQ X -Mapk1 ERK2 P63085 mouse MAST2 17776 Q60592 Mast2 mouse S1337 4727576 KsAEPPRsPLLKRVQ X -Mapk1 ERK2 P63085 mouse ER-beta 13983 O08537 Esr2 mouse S87 447915 WPTSGHLsPLATHCQ ERbeta_N X -Mapk1 ERK2 P63085 mouse H3 360198 P68433 H3c1 mouse S10 455676 tkQTARkstGGkAPr Histone X 9701; 9711; 9606; 3465; 3642; 3377; 3475; 3458; 5764; 47398; 8481; 8552; 53348; 29237; 66065; 43185; 64522; 52725 -Mapk1 ERK2 P63085 mouse FOXO1A 56458 Q9R1E0 Foxo1 mouse T557 478373 NRLtPVKtPLQVPLS X -Mapk1 ERK2 P63085 mouse calponin 3 71994 Q9DAW9 Cnn3 mouse S293 4776192 QGtGTNGsEIsDsDy X -Mapk1 ERK2 P63085 mouse TPR 108989 F6ZDS4 Tpr mouse S2223 468982 GFAEAIHsPQVAGVP X -Mapk1 ERK2 P63085 mouse FOXO1A 56458 Q9R1E0 Foxo1 mouse S415 478369 NTSLNsPsPNYSKYT X X -Mapk1 ERK2 P63085 mouse ETV1 14009 P41164 Etv1 mouse T139 3059605 MRPSNPPtPSStPVs ETS_PEA3_N X -Mapk1 ERK2 P63085 mouse CDC42EP2 104252 Q8JZX9 Cdc42ep2 mouse S101 4270888 RELPDGLsPLLKNAI X -Mapk1 ERK2 P63085 mouse RBPMS iso2 19663 Q9WVB0-2 Rbpms mouse T118 3208560 VGtPNPStPLPNTVP X -Mapk1 ERK2 P63085 mouse AHNAK 66395 E9Q616 Ahnak mouse S2985 4693290 GPsLDIKsPKLDVNA X -Mapk1 ERK2 P63085 mouse ETV1 14009 P41164 Etv1 mouse T143 3059604 NPPtPSStPVsPLHH ETS_PEA3_N X -Mapk1 ERK2 P63085 mouse ATG2B 76559 Q80XK6 Atg2b mouse T398 21686700 YETETARtPSSREEE X -Mapk1 ERK2 P63085 mouse MAST1 56527 Q9R1L5 Mast1 mouse S1260 4784799 KsAEPPRsPLLKRVQ X -Mapk1 ERK2 P63085 mouse FRA2 14284 P47930 Fosl2 mouse S120 470354 RRRDEQLsPEEEEKR X -Mapk1 ERK2 P63085 mouse STXBP1 20910 O08599 Stxbp1 mouse S241 36440508 DRGFDPSsPVLHELT Sec1 X X -Mapk1 ERK2 P63085 mouse TPR 108989 F6ZDS4 Tpr mouse T2205 469185 EDRTVPstPtLVVPH X -Mapk1 ERK2 P63085 mouse lamin A/C 16905 P48678 Lmna mouse S22 452604 QAsstPLsPtRItRL X 2026; 13448 -Mapk1 ERK2 P63085 mouse MAPKAPK2 17164 P49138 Mapkapk2 mouse T320 448273 QsTKVPQtPLHtsRV X 3007; 3041 -Mapk1 ERK2 P63085 mouse TNF-R1 21937 P25118 Tnfrsf1a mouse S299 450967 PVSStPIsPIFGPSN X X -Mapk1 ERK2 P63085 mouse GJA1 14609 P23242 Gja1 mouse S279 448853 SsPtAPLsPMsPPGy X -Mapk1 ERK2 P63085 mouse KSR 16706 Q61097 Ksr1 mouse T260 449298 sFItPPttPQLRRHA X X -Mapk1 ERK2 P63085 mouse AHNAK 66395 E9Q616 Ahnak mouse S217 3250916 PsGsGPAsPttGsAV X -Mapk1 ERK2 P63085 mouse LARP 73158 Q6ZQ58 Larp1 mouse S751 453830 LPttVPEsPNyRNAR X -Mapk1 ERK2 P63085 mouse RIP140 268903 Q8CBD1 Nrip1 mouse T202 456686 KDQKSGPtLPDVtPN NRIP1_repr_1 X -Mapk1 ERK2 P63085 mouse TNF-R1 21937 P25118 Tnfrsf1a mouse S273 450968 PAPsPAFsPTSGFNP X X -Mapk1 ERK2 P63085 mouse CDC42EP1 104445 Q91W92 Cdc42ep1 mouse S113 3193874 SPAPPPIsPIIKNAI X -Mapk1 ERK2 P63085 mouse RAPH1 iso4 77300 F2Z3U3 Raph1 mouse S611 3203571 TSLMPPLsPQTKIIT X -Mapk1 ERK2 P63085 mouse AHNAK 66395 E9Q616 Ahnak mouse S4890 470907 KAEAPLPsPKLEGEI X -Mapk1 ERK2 P63085 mouse LOK 20868 O55098 Stk10 mouse T950 449363 EAEPRPTtPsKASNF X -Mapk1 ERK2 P63085 mouse LARP 73158 Q6ZQ58 Larp1 mouse T278 4928285 PVSVAPPtPAWQPET X -Mapk1 ERK2 P63085 mouse GJA1 24392 P08050 Gja1 rat S279 448853 SSPTAPLsPMsPPGY X -Mapk1 ERK2 P63085 mouse PR 18667 Q00175 Pgr mouse S294 447987 SPIAPGRsPLATTVV Prog_receptor X 13736 -Mapk1 ERK2 P63085 mouse ARHGEF17 207212 Q80U35 Arhgef17 mouse T695 4746259 VsPEtPPtPGALRRR X -Mapk1 ERK2 P63085 mouse FAM195B 192173 Q3UGS4 Mcrip1 mouse T30 9322247 tNssEIFtPAHEENV FAM195 X -Mapk1 ERK2 P63085 mouse FAM207A 108707 P58468 Slx9 mouse S38 4709532 VEPALPQsPAGGAGA X -Mapk1 ERK2 P63085 mouse KHDRBS1 20218 Q60749 Khdrbs1 mouse T71 449877 PPLLPPStPGPDAtV X -Mapk1 ERK2 P63085 mouse RELL1 100532 Q8K2J7 Rell1 mouse T262 3253153 VNGDVPAtPVKRERs X -Mapk1 ERK2 P63085 mouse ETV1 14009 P41164 Etv1 mouse S94 3059606 KIKKEPHsPCSELGS ETS_PEA3_N X -Mapk1 ERK2 P63085 mouse SPT5 20924 O55201 Supt5h mouse S664 468817 VGGFtPMsPRISsPM X -Mapk1 ERK2 P63085 mouse SMRT 20602 Q9WU42 Ncor2 mouse T1718 21686728 LPVLVPPtPGTPATA X -Mapk1 ERK2 P63085 mouse vinexin 20410 Q9R1Z8 Sorbs3 mouse T648 21686738 SQTQSLNtPGPTLSH X -Mapk1 ERK2 P63085 mouse ER-beta 13983 O08537 Esr2 mouse S105 447914 LYAEPQKsPWCEARS ERbeta_N X -Mapk1 ERK2 P63085 mouse RAI1 19377 Q61818 Rai1 mouse T1051 3865777 TALSEPQtPGPPGLT X -Mapk1 ERK2 P63085 mouse ELK1 13712 P41969 Elk1 mouse S384 447872 IHFWSTLsPIAPRsP X 9181; 9186 -Mapk1 ERK2 P63085 mouse DNAJC30 66114 P59041 Dnajc30 mouse T137 21686706 PPRPPPYtPRAPGGS X -Mapk1 ERK2 P63085 mouse Kv4.2 16508 Q9Z0V2 Kcnd2 mouse S616 457613 EGDDRPEsPEYsGGN X -Mapk1 ERK2 P63085 mouse FOXO3A 56484 Q9WVH4 Foxo3 mouse S293 472326 QLSkWPGsPTSRssD X 5538 -Mapk1 ERK2 P63085 mouse SAFB1 224903 D3YXK2 Safb mouse S366 468668 RAPtAALsPEPQDsK X -Mapk1 ERK2 P63085 mouse MEK1 26395 P31938 Map2k1 mouse T292 448287 EtPPRPRtPGRPLsS Pkinase X X 26975 -Mapk1 ERK2 P63085 mouse WIZ 22404 O88286 Wiz mouse S1016 4699701 GLTHPsssPLLKKAP X -Mapk1 ERK2 P63085 mouse BAT2 53761 Q7TSC1 Prrc2a mouse S1217 452699 KLISGPLsPMsRAGN X -Mapk1 ERK2 P63085 mouse NR4A2 4929 P43354 NR4A2 human S126 487424 SVYYKPssPPtPTtP X -Mapk1 ERK2 P63085 mouse SNED1 208777 Q70E20 Sned1 mouse T1239 21686730 NDHSAPEtPTQSSRF X -Mapk1 ERK2 P63085 mouse 4E-T 74203 Q9EST3 Eif4enif1 mouse S114 21686708 DDLDVVLsPQRRsFG EIF4E-T X -Mapk1 ERK2 P63085 mouse AKAP12 83397 Q9WTQ5 Akap12 mouse S273 476342 KPLEsPtsPVSNETT X -Mapk1 ERK2 P63085 mouse KSR 16706 Q61097 Ksr1 mouse S443 449300 TTSSTPSsPAPFLTS X X -Mapk1 ERK2 P63085 mouse MAP1A 17754 Q9QYR6 Map1a mouse T2182 481116 ALALVPGtPtRtRHD X -Mapk1 ERK2 P63085 mouse DLG5 71228 E9Q9R9 Dlg5 mouse T1279 3843835 ERIKIPLtPRYPRSV X -Mapk1 ERK2 P63085 mouse PAR3-alpha 81918 Q9Z340 Pard3 rat S1116 28758704 ALNARPQsPREGHLM X -Mapk1 ERK2 P63085 mouse BIM 12125 O54918 Bcl2l11 mouse S65 449330 GPLAPPAsPGPFATR X 4581; 4585 -Mapk1 ERK2 P63085 mouse FOXO1A 56458 Q9R1E0 Foxo1 mouse S413 478368 PPNTSLNsPsPNYSK X X -Mapk1 ERK2 P63085 mouse p53 22059 P02340 Tp53 mouse S18 447490 IsLELPLsQEtFsGL P53_TAD X X 9284; 9286; 12571; 56979 -Mapk1 ERK2 P63085 mouse Spinophilin 217124 Q6R891 Ppp1r9b mouse S15 455339 GPGGPLRsAsPHRSA X X -Mapk1 ERK2 P63085 mouse ELYS 226747 Q8CJF7 Ahctf1 mouse T1954 14573029 TGLDVPAtPRKRGRP X -Mapk1 ERK2 P63085 mouse XRN2 24128 Q9DBR1 Xrn2 mouse T439 3211959 FTPSGILtPHALGsR XRN_M X -Mapk1 ERK2 P63085 mouse AHNAK 66395 E9Q616 Ahnak mouse T695 10788942 LPEVsVKtPKIsMPD X -Mapk1 ERK2 P63085 mouse PKCA 18750 P20444 Prkca mouse T638 448685 TRGQPVLtPPDQLVI Pkinase_C X X 9375 -Mapk1 ERK2 P63085 mouse FRA2 14284 P47930 Fosl2 mouse S230 452625 QEPPEEDsPSSSAGM X -Mapk1 ERK2 P63085 mouse BIK 12124 O70337 Bik mouse T116 25171001 IWSWRVLtPGAWVSP bcl-2I13 X -Mapk1 ERK2 P63085 mouse MYO9B 17925 Q9QY06 Myo9b mouse T1317 1983800 RATGAALtPtEERRI X -Mapk1 ERK2 P63085 mouse KLF4 16600 Q60793 Klf4 mouse S132 24976100 ASASSSSsPASSGPA X -Mapk1 ERK2 P63085 mouse NR4A2 4929 P43354 NR4A2 human T132 487426 ssPPtPTtPGFQVQH X -Mapk1 ERK2 P63085 mouse GJA1 24392 P08050 Gja1 rat S255 448852 HATTGPLsPskDCGs X -Mapk1 ERK2 P63085 mouse NIPA 232679 Q80YV2 Zc3hc1 mouse S358 483339 tRsWEsssPVDRPEL X -Mapk1 ERK2 P63085 mouse p90RSK 20111 P18653 Rps6ka1 mouse S369 447990 HQLFRGFsFVATGLM Pkinase_C X 9341; 9335; 13575; 11989; 12032; 75266; 93317; 13397; 13588 -Mapk1 ERK2 P63085 mouse hnRNP H2 56258 P70333 Hnrnph2 mouse S104 455396 LKHtGPNsPDtANDG X -Mapk1 ERK2 P63085 mouse NR4A2 4929 P43354 NR4A2 human T129 487425 YKPssPPtPTtPGFQ X -Mapk1 ERK2 P63085 mouse AIM1 11630 E9PVP1 Crybg1 mouse T655 8143602 QDATsPLtPTRLLNI X -Mapk1 ERK2 P63085 mouse Cofilin-1 12631 P18760 Cfl1 mouse T25 7990494 MkVRKSstPEEVKkR Cofilin_ADF X X -Mapk1 ERK2 P63085 mouse Ets-1 23871 P27577 Ets1 mouse S41 22650305 VPLLtPSsKEMMSQA X -Mapk1 ERK2 P63085 mouse NICE-4 74383 Q80X50 Ubap2l mouse T864 449365 IPFPtPTtPLTGRDG X -Mapk1 ERK2 P63085 mouse TPR 108989 F6ZDS4 Tpr mouse T2184 4743148 VGrGLQLtPGIGGMQ X -Mapk1 ERK2 P63085 mouse H3 iso3 15081 P84244 H3f3b mouse S28 455677 ATkAArksAPSTGGV Histone X 9713 -Mapk1 ERK2 P63085 mouse SUPV3L1 338359 Q80YD1 Supv3l1 mouse S725 3245612 NKATEPLsPSDKELP X -Mapk1 ERK2 P63085 mouse Fos 314322 P12841 Fos rat T325 448483 TELEPLCtPVVTCtP X -Mapk1 ERK2 P63085 mouse JunB 16477 P09450 Junb mouse S256 452631 RDAtPPVsPINMEDQ X -Mapk1 ERK2 P63085 mouse DCP1A 75901 Q91YD3 Dcp1a mouse S339 3213297 LPLsPVLsPTLPAEA X -Mapk1 ERK2 P63085 mouse TBC1D23 67581 Q8K0F1 Tbc1d23 mouse T514 483869 sFIENSStPVDRHVs TBC1D23_C X -Mapk1 ERK2 P63085 mouse DNCLI1 235661 Q8R1Q8 Dync1li1 mouse S516 449258 VsPttPtsPtEGEAs DLIC X -Mapk1 ERK2 P63085 mouse TFPI 21788 O54819 Tfpi mouse S210 21686734 NNIVVPQsPKVPRRR X -Mapk1 ERK2 P63085 mouse TANC1 66860 Q0VGY8 Tanc1 mouse S1561 9831758 SSQNPPPsPMPGRVS X -Mapk1 ERK2 P63085 mouse HIF1A 3091 Q16665 HIF1A human S643 470106 kILIAsPsPTHIHkE X -Mapk1 ERK2 P63085 mouse FBXW7 55294 Q969H0 FBXW7 human S176 25126709 KRKLDHGsEVRSFSL X -Mapk1 ERK2 P63085 mouse girdin 55704 Q3V6T2 CCDC88A human S233 4725929 HASSSAQsPCGsPGM X -Mapk1 ERK2 P63085 mouse STMN1 16765 P54227 Stmn1 mouse S38 448556 sVPdFPLsPPKKKDL Stathmin X 3426; 4191 -Mapk1 ERK2 P63085 mouse FRA2 14284 P47930 Fosl2 mouse S320 4707550 QSSDSLNsPtLLAL_ X -Mapk1 ERK2 P63085 mouse BAT2 53761 Q7TSC1 Prrc2a mouse T609 452701 EEVPPPttPPAPKME X -Mapk1 ERK2 P63085 mouse STXBP1 20910 O08599 Stxbp1 mouse T574 454395 IGSTHILtPQKLLDt Sec1 X -Mapk1 ERK2 P63085 mouse RPS3 27050 P62908 Rps3 mouse T221 452652 kDEILPttPIsEQkG X -Mapk1 ERK2 P63085 mouse MAST4 328329 Q811L6 Mast4 mouse S1436 4749578 KsAEPPRsPLLKRVQ X -Mapk1 ERK2 P63085 mouse NFAT3 73181 Q8K120 Nfatc4 mouse S676 455348 SNGRRKRsPTQSFKF RHD_dimer X -Mapk1 ERK2 P63085 mouse Bcl-2 12043 P10417 Bcl2 mouse S70 448395 RDMAARtsPLRPLVA X -Mapk1 ERK2 P63085 mouse FAK 14083 P34152 Ptk2 mouse S910 447964 KLQPQEIsPPPTANL X X -Mapk1 ERK2 P63085 mouse STF-1 26423 P33242 Nr5a1 mouse S203 447603 EYPEPYAsPPQQPGP X -Mapk1 ERK2 P63085 mouse IRS2 384783 P81122 Irs2 mouse T653 15228280 DDGyMPMtPGAALRs X -Mapk1 ERK2 P63085 mouse UBAP2 68926 Q91VX2 Ubap2 mouse T964 21686736 VALSTPPtPFQQASG X -Mapk1 ERK2 P63085 mouse PHLDB1 102693 Q6PDH0 Phldb1 mouse S445 468424 RTLQPPEsPRLGRRG X -Mapk1 ERK2 P63085 mouse GTSE1 29870 Q8R080 Gtse1 mouse S460 4763255 PQFSVGEsPGGVtPK X -Mapk1 ERK2 P63085 mouse RAI14 75646 Q9EP71 Rai14 mouse T249 486552 SQDADLKtPtKPKQH Ank_2 X -Mapk1 ERK2 P63085 mouse girdin 55704 Q3V6T2 CCDC88A human S237 4725935 SAQsPCGsPGMKRTE X -Mapk1 ERK2 P63085 mouse DLG7 218977 Q8K4R9 Dlgap5 mouse S328 456337 SYQVAPLsPRSANAF X -Mapk1 ERK2 P63085 mouse ATF-2 11909 P16951 Atf2 mouse T53 448225 IVADQtPtPtRFLKN X X 9225; 9221; 5112; 94125; 13850; 40749; 15411; 24329; 61584; 27934; 92109; 20534; 35858 -Mapk1 ERK2 P63085 mouse FOXO1A 56458 Q9R1E0 Foxo1 mouse S467 478371 KELLtsDsPPHNDIM FOXO_KIX_bdg X X -Mapk1 ERK2 P63085 mouse TNF-R1 21937 P25118 Tnfrsf1a mouse S269 451128 KPLtPAPsPAFsPTS X X -Mapk1 ERK2 P63085 mouse TPX2 72119 A2APB8 Tpx2 mouse T369 455432 KIARDPQtPILQtKY TPX2_importin X -Mapk1 ERK2 P63085 mouse MAP1B 17755 P14873 Map1b mouse T1784 456417 ksDIsPLtPREssPL X -Mapk1 ERK2 P63085 mouse TNF-R1 21937 P25118 Tnfrsf1a mouse T265 450966 EKAGKPLtPAPsPAF X X -Mapk1 ERK2 P63085 mouse SHC1 20416 P98083 Shc1 mouse S36 448508 TPPEELPsPSASSLG X -Mapk1 ERK2 P63085 mouse Ets-1 23871 P27577 Ets1 mouse T38 447950 CADVPLLtPSsKEMM X -Mapk1 ERK2 P63085 mouse p70S6K 6198 P23443 RPS6KB1 human S434 448356 sFEPKIRsPRRFIGs X -Mapk1 ERK2 P63085 mouse AHNAK 66395 E9Q616 Ahnak mouse S4906 7103416 VPDVDIssPGINVEA X -Mapk1 ERK2 P63085 mouse STMN1 16765 P54227 Stmn1 mouse S25 448555 QAFELILsPRskEsV Stathmin X X -Mapk1 ERK2 P63085 mouse C/EBP-beta 12608 P28033 Cebpb mouse T188 447878 sSssPPGtPSPADAK X X 3084 -Mapk1 ERK2 P63085 mouse NOXA1 241275 Q8CJ00 Noxa1 mouse Y252 1869151102 GHTSPGLyDSLLASR X -Mapk1 ERK2 P63085 mouse BIM 12125 O54918 Bcl2l11 mouse S100 449602 FSFDTDRsPAPMsCD X -Mapk1 ERK2 P63085 mouse RCAN1 54720 Q9JHG6 Rcan1 mouse S165 456023 FLIsPPAsPPVGWKQ Calcipressin X -Mapk1 ERK2 P63085 mouse PCYT1A 140544 P19836 Pcyt1a rat S315 451321 GRMLQAIsPKQsPss X -Mapk1 ERK2 P63085 mouse EGFR 13649 Q01279 Egfr mouse T695 448054 RELVEPLtPsGEAPN X 3056; 8808 -Mapk1 ERK2 P63085 mouse CEP170B 217882 Q80U49 Cep170b mouse T968 485661 KNGPsPTtPQtPGPQ CEP170_C X -Mapk1 ERK2 P63085 mouse FOXO1A 56458 Q9R1E0 Foxo1 mouse S284 478910 GQEGPGDsPGSQFSK X -Mapk1 ERK2 P63085 mouse DOCK1 330662 Q8BUR4 Dock1 mouse T1772 3801979 QQtPPPVtPRAKLSF X -Mapk1 ERK2 P63085 mouse REXO1 66932 Q7TT28 Rexo1 mouse T259 21686724 SRGAEPYtPALkKPC X -Mapk1 ERK2 P63085 mouse CEP170B 217882 Q80U49 Cep170b mouse T529 3843372 PVLPAPLtPRGAsPV X -Mapk1 ERK2 P63085 mouse MYBBP1A 18432 Q7TPV4 Mybbp1a mouse S1280 459879 VNGAtPVsPIEPEsK X -Mapk1 ERK2 P63085 mouse ETV3 27049 Q8R4Z4 Etv3 mouse S139 14159952 SSGVVPQsAPPVPTA X -Mapk1 ERK2 P63085 mouse SMAD4 17128 P97471 Smad4 mouse T276 449628 GSRTAPYtPNLPHHQ X X -Mapk1 ERK2 P63085 mouse NDEL1 83431 Q9ERR1 Ndel1 mouse T219 468252 ASLsLPAtPVGKGTE NUDE_C X -Mapk1 ERK2 P63085 mouse FOXO1A 56458 Q9R1E0 Foxo1 mouse S246 471071 EGGkSGksPRRRAAs X X -Mapk1 ERK2 P63085 mouse GLI2 14633 Q0VGT2 Gli2 mouse T885 21686712 ATGGPPPtPLPGLDR X -Mapk1 ERK2 P63085 mouse ELK1 2002 P19419 ELK1 human S383 447872 IHFWSTLsPIAPRsP X 9181; 9186 -Mapk1 ERK2 P63085 mouse RAPH1 iso4 77300 F2Z3U3 Raph1 mouse T879 5518475 SQFPPPPtPPPVDSQ X -Mapk1 ERK2 P63085 mouse Jun 16476 P05627 Jun mouse S246 450451 PGEtPPLsPIDMESQ X 2994 -Mapk1 ERK2 P63085 mouse MEK1 26395 P31938 Map2k1 mouse T386 448288 IGLNQPstPtHAASI X X -Mapk1 ERK2 P63085 mouse TH 25085 P04177 Th rat S31 448544 KQAEAVtsPRFIGRR TOH_N X 3370; 13041 -Mapk1 ERK2 P63085 mouse p53 7157 P04637 TP53 human S15 447490 PsVEPPLsQEtFsDL P53_TAD X 4030; 9235; 9284; 9286; 8695; 8514; 82530; 56979 -Mapk1 ERK2 P63085 mouse PLA2G4A 18783 P47713 Pla2g4a mouse S505 447597 LNTSYPLsPLRDFss PLA2_B X 2831; 53044 -Mapk1 ERK2 P63085 mouse MEK1 100009316 P29678 MAP2K1 rabbit T292 448287 ETPPRPRtPGRPLsS Pkinase X -Mapk1 ERK2 P63085 mouse GATA4 14463 Q08369 Gata4 mouse S105 449604 AYTPPPVsPRFSFPG GATA-N X -Mapk1 ERK2 P63085 mouse Nur77 79240 P22829 Nr4a1 rat T142 15068600 CSAPSPPtPNFQPSQ X -Mapk1 ERK2 P63085 mouse RBM9 93686 Q8BP71 Rbfox2 mouse T65 5968614 GMQNEPLtPGYHGFP X -Mapk1 ERK2 P63085 mouse Nogo 68585 Q99P72 Rtn4 mouse T156 15412809 EPAAPPStPAAPKRR X -Mapk1 ERK2 P63085 mouse RRas 6237 P10301 RRAS human S201 18015221 QEQELPPsPPsAPRK X -Mapk1 ERK2 P63085 mouse AHNAK 66395 E9Q616 Ahnak mouse T5567 3148545 REFsAPstPtGtLEF X -Mapk1 ERK2 P63085 mouse HIF1A 3091 Q16665 HIF1A human S641 470105 DIkILIAsPsPTHIH X -Mapk1 ERK2 P63085 mouse RIP140 268903 Q8CBD1 Nrip1 mouse T207 455626 GPtLPDVtPNLIRDS NRIP1_repr_1 X -Mapk1 ERK2 P63085 mouse Ets-2 23872 P15037 Ets2 mouse T72 447688 SCELPLLtPCSKAVM X -Mapk1 ERK2 P63085 mouse OGA 76055 Q9EQQ9 Oga mouse T709 472476 FFQPPPLtPTSKVYT X -Mapk1 ERK2 P63085 mouse KHDRBS1 20218 Q60749 Khdrbs1 mouse S58 449876 PrGGArAsPAtQPPP X -Mapk1 ERK2 P63085 mouse Kv7.2 3785 O43526 KCNQ2 human S414 58948900 KDPPPEPsPSKGSPC X X -Mapk1 ERK2 P63085 mouse BIM 12125 O54918 Bcl2l11 mouse T112 449071 sCDKStQtPsPPCQA X -Mapk1 ERK2 P63085 mouse ERF 13875 P70459 Erf mouse T529 448321 GEsGGPLtPRRVssD X -Mapk1 ERK2 P63085 mouse NUP153 218210 Q80WR0 Nup153 mouse T610 3191095 sVLDILktPGFAsPK Nup153 X -Mapk1 ERK2 P63085 mouse FOXO1A 56458 Q9R1E0 Foxo1 mouse S295 471972 QFSKWPAsPGSHsND X -Mapk1 ERK2 P63085 mouse K8 3856 P05787 KRT8 human S432 448540 sAyGGLtsPGLsysL X -Mapk1 ERK2 P63085 mouse DCP1A 75901 Q91YD3 Dcp1a mouse S335 3213294 PsYTLPLsPVLsPTL X -Mapk1 ERK2 P63085 mouse UGDH 22235 O70475 Ugdh mouse T474 469003 SSKRIPytPGEIPkF X -Mapk1 ERK2 P63085 mouse KHDRBS1 20218 Q60749 Khdrbs1 mouse T84 449878 tVVGSAPtPLLPPSA X -Mapk1 ERK2 P63085 mouse NR4A2 4929 P43354 NR4A2 human T185 487427 FKQsPPGtPVSSCQM X -Mapk1 ERK2 P63085 mouse Caldesmon 800 Q05682 CALD1 human S789 448466 QsVDKVtsPtKV___ X -Mapk1 ERK2 P63085 mouse GJA1 14609 P23242 Gja1 mouse S255 448852 HAtTGPLsPskDCGs X -Mapk1 ERK2 P63085 mouse STAT1 20846 P42225 Stat1 mouse S727 447753 tDNLLPMsPEEFDEM STAT1_TAZ2bind X X 9177; 8826; 62390 -Mapk1 ERK2 P63085 mouse RIPK3 56532 Q9QZL0 Ripk3 mouse T399 21686726 tLPFRGTtPGPVFTE X -Mapk1 ERK2 P63085 mouse TH 21823 P24529 Th mouse S31 448544 KQAEAVtsPRFIGRR TOH_N X 3370; 13041 -NEK10 NEK10 Q6ZWH5 human RYR1 20190 E9PZQ0 Ryr1 mouse T4338 34348504 ALLWALVtRAGGAGA X -Cdk1 CDK1 P11440 mouse MCM4 17217 P49717 Mcm4 mouse T109 450002 PRsGVRGtPVRQRPD X -Cdk1 CDK1 P11440 mouse C/EBP-alpha 12606 P53566 Cebpa mouse S193 1868113505 PPPHPHAsPAHLAAP X X -Cdk1 CDK1 P11440 mouse MyoD 17927 P10085 Myod1 mouse S5 470072 ___MELLsPPLRDID X X -Cdk1 CDK1 P11440 mouse POLR2A 20020 P08775 Polr2a mouse S1616 450204 TPQSPSYsPtsPSYS RNA_pol_Rpb1_R X 4735; 13499; 13546; 31262 -Cdk1 CDK1 P11440 mouse MyoD 17927 P10085 Myod1 mouse S200 40684505 SGDSDASsPRsNCSD Myf5 X X -Cdk1 CDK1 P11440 mouse PAK1 18479 O88643 Pak1 mouse T212 448176 VIEPLPVtPtRDVAt X -Cdk1 CDK1 P11440 mouse lamin A/C 16905 P48678 Lmna mouse S392 452606 ERLRLsPsPtsQRsR X -Cdk1 CDK1 P11440 mouse FOXO1A 2308 Q12778 FOXO1 human S249 471071 EGGkSGksPrRrAAs X -Cdk1 CDK1 P11440 mouse MSX1 17701 P13297 Msx1 mouse S136 50783957 DALVkAEsPEKLDRT X -Cdk1 CDK1 P11440 mouse MCM3 17215 P25206 Mcm3 mouse T719 449197 tQMPQVHtPKtDDsQ X -Cdk1 CDK1 P11440 mouse C/EBP-alpha 12606 P53566 Cebpa mouse S21 448308 PMSSHLQsPPHAPSN X 2841 -Cdk1 CDK1 P11440 mouse SYN3 8224 O14994 SYN3 human S470 455901 PQGQQPLsPQsGsPQ X -Cdk1 CDK1 P11440 mouse desmin 395906 P02542 DES chicken T64 1868158502 TFRTTRVtPLRTYGS Filament_head X -Cdk1 CDK1 P11440 mouse Vimentin 101824289 P02544 Vim hamster S55 451514 SRSLYSSsPGGAYVT Filament_head X -Cdk1 CDK1 P11440 mouse CK2B 100873151 P67869 CSNK2B chicken S209 451751 QAASNFKsPVKTIR_ X -Cdk1 CDK1 P11440 mouse MCM4 17217 P49717 Mcm4 mouse T19 448634 SSRRGRVtPtQsLRs X -Cdk1 CDK1 P11440 mouse CREM 12916 P27699 Crem mouse S290 450066 AsPGsLHsPQQLAEE X X -Cdk1 CDK1 P11440 mouse SOX2 20674 P48432 Sox2 mouse S39 18913847 TGGNQkNsPDRVKRP X -Cdk1 CDK1 P11440 mouse K5 110308 Q922U2 Krt5 mouse T145 288031706 TVNQNLLtPLNLQID Keratin_2_head X -Cdk1 CDK1 P11440 mouse Abl 11350 P00520 Abl1 mouse S569 450293 LDSEPAVsPLLPRKE X -Cdk1 CDK1 P11440 mouse K5 110308 Q922U2 Krt5 mouse T24 15420502 FsAAsAItPsVsRTs Keratin_2_head X X -Cdk1 CDK1 P11440 mouse Vimentin 22352 P20152 Vim mouse S56 451514 sRsLysssPGGAyVt Filament_head X 3877; 7391 -Cdk1 CDK1 P11440 mouse desmin 395906 P02542 DES chicken S6 466342 __SQSYSsSQRVSsY X -Cdk1 CDK1 P11440 mouse PPP1R1A 58200 Q9ERT9 Ppp1r1a mouse S67 447758 LKSTLsMsPRQRKKM DARPP-32 X -Cdk1 CDK1 P11440 mouse C/EBP-beta 24253 P21272 Cebpb rat S64 456166 HERAIDFsPYLEPLA X -Cdk1 CDK1 P11440 mouse BAD 12015 Q61337 Bad mouse S128 447861 EGMEEELsPFRGRsR Bcl-2_BAD X -Cdk1 CDK1 P11440 mouse PPP1CA 19045 P62137 Ppp1ca mouse T320 448686 NPGGRPItPPRNsAK X X -Cdk1 CDK1 P11440 mouse CREM 12916 P27699 Crem mouse S284 450065 QGVVMAAsPGsLHsP X X -Cdk1 CDK1 P11440 mouse Src iso1 20779 P05480-1 Src mouse S74 450326 NSSDtVTsPQRAGPL X -Cdk1 CDK1 P11440 mouse UBE1 7317 P22314 UBA1 human S4 449950 ____MSssPLsKKRR X X -Cdk1 CDK1 P11440 mouse talin 1 21894 P26039 Tln1 mouse S1589 27533485 SSVPAQIsPEGRAAM X -Cdk1 CDK1 P11440 mouse CREM 12916 P27699 Crem mouse S133 448412 EILSRRPsYRKILNE pKID X 4095; 14228; 14001 -Cdk1 CDK1 P11440 mouse MCM4 17217 P49717 Mcm4 mouse T7 450000 _MssPAstPsRRSSR X -Cdk1 CDK1 P11440 mouse Plectin-1 64204 P30427 Plec rat T4542 451386 GGLIEPDtPGRVSLD Plectin X -Cdk1 CDK1 P11440 mouse POLR2A 20020 P08775 Polr2a mouse S1619 447616 SPSYsPtsPSYSPTS RNA_pol_Rpb1_R X 4735; 13523; 13546; 67221 -Cdk1 CDK1 P11440 mouse CDK7 12572 Q03147 Cdk7 mouse S164 450041 GLAKsFGsPNRAytH Pkinase X -Cdk1 CDK1 P11440 mouse desmin 13346 P31001 Des mouse S32 466343 sLGsPLssPVFPrAG Filament_head X -Cdk1 CDK1 P11440 mouse CDK1 12534 P11440 Cdk1 mouse Y15 447610 EKIGEGtyGVVyKGR Pkinase X 4539; 9111; 14566; 77897 -Cdk1 CDK1 P11440 mouse CREM 12916 P27699 Crem mouse S156 450064 PKIEEEKsEEEGTPP X X -Cdk1 CDK1 P11440 mouse FOXO1A 56458 Q9R1E0 Foxo1 mouse S246 471071 EGGkSGksPRRRAAs X -Cdk1 CDK1 P11440 mouse MCM4 17217 P49717 Mcm4 mouse S87 460696 PLDFDVSsPLTYGTP X -Cdk1 CDK1 P11440 mouse Abl 11350 P00520 Abl1 mouse T547 450294 EQKDAPDtPELLHTK X -Cdk1 CDK1 P11440 mouse MCM4 17217 P49717 Mcm4 mouse S32 450001 RsEESRssPNRRRRG X -Cdk1 CDK1 P11440 mouse desmin 395906 P02542 DES chicken S22 466343 RTFGGGTsPVFPRAs Filament_head X -Cdk1 CDK1 P11440 mouse MCM3 17215 P25206 Mcm3 mouse S112 2840507 SFGSKHVsPRTLTSC MCM_OB X 12686 -Cdk1 CDK1 P11440 mouse Vimentin 7431 P08670 VIM human S56 451514 srsLyAssPGGVyAt Filament_head X 3877; 7391 -Rps6kb1 p70S6K P67999 rat GSK3B 84027 P18266 Gsk3b rat S9 449111 SGRPRTTsFAESCKP X 9336; 9331; 9327; 9323; 9322; 9325; 5558; 8566; 79774; 8466; 25462; 14026; 14332; 14310; 14630 -Rps6kb1 p70S6K P67999 rat SREBP-1 iso1 78968 P56720-1 Srebf1 rat S419 56654316 LGSRGSssGGsDsEP X -Rps6kb1 p70S6K P67999 rat S6 29304 P62755 Rps6 rat S235 448092 IAKRRRLssLRAsts X 5006; 4856; 4857; 4858; 4851; 4803; 2211; 3945; 3985; 5316; 4854; 8520; 48319; 40643; 9865; 38573; 14733; 27036; 34411; 62016; 62788; 81736; 97935; 99457; 15448 -Rps6kb1 p70S6K P67999 rat S6 6194 P62753 RPS6 human S240 448094 RLssLRAstsKsEss X 2215; 5364; 5018; 93315; 5044; 13020; 14236; 9468; 35708; 88441; 34918 -Rps6kb1 p70S6K P67999 rat SREBP-1 iso1 78968 P56720-1 Srebf1 rat S418 1869370300 SLGSRGSssGGsDsE X -Rps6kb1 p70S6K P67999 rat BAD 64639 O35147 Bad rat S137 447862 PFRGRsRsAPPNLWA Bcl-2_BAD X 9295; 5286; 4366 -Rps6kb1 p70S6K P67999 rat PFKFB2 287019 P26285 PFKFB2 cow S484 452046 IRRPRNYsVGSRPLQ X -Rps6kb1 p70S6K P67999 rat SREBP-1 iso1 78968 P56720-1 Srebf1 rat S422 4785186 RGSssGGsDsEPDSP X -Rps6kb1 p70S6K P67999 rat S6 6194 P62753 RPS6 human S244 448095 LRAstsKsEssQK__ X 2215; 5364; 5018; 93315; 5044; 13020; 14236; 9468; 35708; 88441; 34918 -Rps6kb1 p70S6K P67999 rat S6 29304 P62755 Rps6 rat S240 448094 RLssLRAstsKsESs X 2215; 5364; 5018; 93315; 5044; 13020; 14236; 9468; 35708; 88441; 34918 -Rps6kb1 p70S6K P67999 rat S6 29304 P62755 Rps6 rat S236 448093 AKRRRLssLRAstsK X 5006; 4856; 4857; 4858; 4851; 4803; 2211; 3945; 3985; 5316; 4854; 8520; 48319; 40643; 9865; 38573; 14733; 27036; 34411; 62016; 62788; 81736; 97935; 99457; 15448 -Rps6kb1 p70S6K P67999 rat PFKFB2 287019 P26285 PFKFB2 cow S467 448460 PVRMRRNsFTPLSSS X -Rps6kb1 p70S6K P67999 rat S6 29304 P62755 Rps6 rat S244 448095 LRAstsKsESsQK__ X 2215; 5364; 5018; 93315; 5044; 13020; 14236; 9468; 35708; 88441; 34918 -PAK3 PAK3 O75914 human MYO6 397085 Q29122 MYO6 pig T406 449089 TAGGAKGtVIKVPLK Myosin_head X -PAK3 PAK3 O75914 human GluR1 50592 P19490 Gria1 rat S863 448566 TSTLPRNsGAGASGG X 8084 -PAK3 PAK3 O75914 human Caldesmon 373965 P12957 CALD1 chicken S702 456707 GLKVGVSsRINEWLT Caldesmon X -PAK3 PAK3 O75914 human Caldesmon 373965 P12957 CALD1 chicken S672 456706 EGVRNIKsMWEKGNV Caldesmon X -PAK3 PAK3 O75914 human PAK3 18481 Q61036 Pak3 mouse S154 448123 VNNQKYMsFTSGDKs X 2606 -PAK3 PAK3 O75914 human MEK1 170851 Q01986 Map2k1 rat S298 448284 RtPGRPLsSYGMDSR Pkinase X 9128; 98195 -Dyrk1b DYRK1B Q9Z188 mouse CCND1 12443 P25322 Ccnd1 mouse T286 447839 EEAGLACtPtDVRDV X X -Dyrk1b DYRK1B Q9Z188 mouse p27Kip1 12576 P46414 Cdkn1b mouse S10 447874 NVRVsNGsPsLERMD X X -Dyrk1b DYRK1B Q9Z188 mouse NKX3-1 4824 Q99801 NKX3-1 human S185 4825101 KTKRkQLssELGDLE X -Dyrk1b DYRK1B Q9Z188 mouse CCND1 12443 P25322 Ccnd1 mouse T288 451435 AGLACtPtDVRDVDI X X -PHKG1 PHKG1 P00518 rabbit PHKA1 100303771 P18688 PHKA1 rabbit S972 455914 KEFGVERsVRPTDSN X -PHKG1 PHKG1 P00518 rabbit Tau iso8 4137 P10636-8 MAPT human S262 447930 NVKskIGstENLkHQ Tubulin-binding X -PHKG1 PHKG1 P00518 rabbit TNNT3 100009527 P02641 TNNT3 rabbit S2 466430 ______MsDEEVEHV X -PHKG1 PHKG1 P00518 rabbit PYGM 100008972 P00489 PYGM rabbit S15 449838 QEKRKQIsVRGLAGV X -PHKG1 PHKG1 P00518 rabbit PHKA1 100303771 P18688 PHKA1 rabbit S1007 455916 TGIMQLKsEIKQVEF X -PHKG1 PHKG1 P00518 rabbit TNNT3 100009527 P02641 TNNT3 rabbit S170 1067211 KKKKALSsMGANYSs Troponin X -PHKG1 PHKG1 P00518 rabbit TNNT3 100009527 P02641 TNNT3 rabbit S177 1067210 sMGANYSsYLAKADQ Troponin X -PHKG1 PHKG1 P00518 rabbit PHKG1 100009297 P00518 PHKG1 rabbit S31 455918 EILGRGVsSVVRRCI Pkinase X -PHKG1 PHKG1 P00518 rabbit PHKA1 100303771 P18688 PHKA1 rabbit S985 455915 SNVSPAIsIHEIGAV X -PHKG1 PHKG1 P00518 rabbit GYS1 100008660 P13834 GYS1 rabbit S8 449898 MPLSRTLsVSsLPGL X -Rock2 ROCK2 Q62868 rat ROCK2 25537 Q62868 Rock2 rat T414 5931301 QLPFIGFtYFRENLL X -Rock2 ROCK2 Q62868 rat SNAP-25 20614 P60879 Snap25 mouse T138 449875 GGFIRRVtNDARENE SNAP-25 X -Rock2 ROCK2 Q62868 rat MYPT1 116670 Q10728 Ppp1r12a rat S854 451999 RPREKRRstGVSFWT X -Rock2 ROCK2 Q62868 rat CLCN3 iso2 84360 P51792-2 Clcn3 rat T532 51381106 LGGVTRMtVSLVVIV Voltage_CLC X -Rock2 ROCK2 Q62868 rat MYPT1 116670 Q10728 Ppp1r12a rat T697 448587 ARQSRRstQGVTLTD X 5163 -DYRK1B DYRK1B Q9Y463 human HDAC5 15184 Q9Z2V6 Hdac5 mouse S270 4788487 KVAERRssPLLRRKD X -DYRK1B DYRK1B Q9Y463 human ID2 3398 Q02363 ID2 human T27 4706880 LGISRSKtPVDDPMS X -DYRK1B DYRK1B Q9Y463 human DYRK1B 9149 Q9Y463 DYRK1B human Y271 458096 CQLGQRIyQyIQsRF Pkinase X X -DYRK1B DYRK1B Q9Y463 human NKX3-1 4824 Q99801 NKX3-1 human S186 7998431 TKRkQLssELGDLEK X -DYRK1B DYRK1B Q9Y463 human p21Cip1 1026 P38936 CDKN1A human S153 456134 sMTDFyHskRrLIFS X X -DYRK1B DYRK1B Q9Y463 human HNF1A 6927 P20823 HNF1A human S249 451310 IQRGVsPsQAQGLGS X -DYRK1B DYRK1B Q9Y463 human NKX3-1 4824 Q99801 NKX3-1 human S185 4825101 KTKRkQLssELGDLE X -DYRK1B DYRK1B Q9Y463 human DYRK1B 9149 Q9Y463 DYRK1B human Y273 449567 LGQRIyQyIQsRFYR Pkinase X X -DYRK1B DYRK1B Q9Y463 human H3F3A 3020 P84243 H3-3A human T45 18545304 PHryrPGtVALrEIR Histone X -DYRK1B DYRK1B Q9Y463 human EHMT2 10919 Q96KQ7 EHMT2 human T555 3827109 IPRGDGVtPPAGtAA X -DYRK1B DYRK1B Q9Y463 human CCND1 595 P24385 CCND1 human T288 451435 VDLACtPtDVRDVDI X -DYRK1B DYRK1B Q9Y463 human DYRK1B 9149 Q9Y463 DYRK1B human S421 50269512 YEPAARIsPLGALQH Pkinase X -DYRK1B DYRK1B Q9Y463 human GYS1 100008660 P13834 GYS1 rabbit S641 448237 YRYPRPAsVPPsPSL Glycogen_syn X X -DYRK1B DYRK1B Q9Y463 human LIN52 91750 Q52LA3 LIN52 human S28 4758466 FEKLDRAsPDLWPEQ LIN52 X -DYRK1B DYRK1B Q9Y463 human SF3B1 23451 O75533 SF3B1 human T434 460652 PARkLtAtPtPLGGM SF3b1 X -MAST4 MAST4 O15021 human SOX9 20682 Q04887 Sox9 mouse S492 1877718900 PSIPQTHsPQHWEQP X -MKNK2 Mnk2 Q9HBH9 human SynGAP 240057 F6SEU4 Syngap1 mouse S788 19014968 MDMARLPsPtKEkPP DUF3498 X -MKNK2 Mnk2 Q9HBH9 human PSF 6421 P23246 SFPQ human S283 3182056 EGFkANLsLLRRPGE X -MKNK2 Mnk2 Q9HBH9 human PSF 6421 P23246 SFPQ human S8 25802101 MSRDRFrsrGGGGGG X -MKNK2 Mnk2 Q9HBH9 human SPRY2 10253 O43597 SPRY2 human S112 465675 APLSRSIsTVssGsR X -MKNK2 Mnk2 Q9HBH9 human EIF4E 1977 P06730 EIF4E human S209 447776 DtATksGsttKNRFV X X 9741 -MKNK2 Mnk2 Q9HBH9 human Plectin-1 5339 Q15149 PLEC human S4642 3196844 RAGsRrGsFDAtGsG X -MKNK2 Mnk2 Q9HBH9 human SPRY2 10253 O43597 SPRY2 human S121 465676 VssGsRSsTRtSTSs X -Syk Syk P48025 mouse Syk 20963 P48025 Syk mouse Y317 447658 STVSFNPyEPtGGPW X 2715 -Syk Syk P48025 mouse Syk 20963 P48025 Syk mouse Y342 447659 LPMDTEVyESPyADP X -Syk Syk P48025 mouse PKCB 18751 P68404 Prkcb mouse Y662 455926 NEFAGFsyTNPEFVI Pkinase_C X X -Syk Syk P48025 mouse HPK1 26411 P70218 Map4k1 mouse Y379 448160 LsDsDDDyDDVDIPA X -Syk Syk P48025 mouse Ikaros 22778 Q03267 Ikzf1 mouse S357 14160239 PsDGPPRsNHsAQDA X -Syk Syk P48025 mouse SH3BP2 24055 Q06649 Sh3bp2 mouse Y183 449092 HEDEDDSyLEPDSPG X -Syk Syk P48025 mouse SH3BP2 24055 Q06649 Sh3bp2 mouse Y174 449091 YPMDNEDyEHEDEDD X -Syk Syk P48025 mouse PKCA 18750 P20444 Prkca mouse Y658 455927 sDFEGFsyVNPQFVH Pkinase_C X X -Syk Syk P48025 mouse SH3BP2 24055 Q06649 Sh3bp2 mouse Y446 449093 EEDsDEDyEKVPLPN X -Syk Syk P48025 mouse Syk 20963 P48025 Syk mouse Y130 447657 KENLIREyVKQTWNL X X -Syk Syk P48025 mouse SWAP-70 20947 Q6A028 Swap70 mouse Y517 450716 RKQALEQyEGVKKKL X X -Syk Syk P48025 mouse Ikaros 22778 Q03267 Ikzf1 mouse S360 4714822 GPPRsNHsAQDAVDN X -Syk Syk P48025 mouse Syk 20963 P48025 Syk mouse Y519 447661 ALRADENyyKAQTHG PK_Tyr_Ser-Thr X 2711; 2710; 12967; 5514; 4349; 6485; 12081; 46994; 16859 -Syk Syk P48025 mouse Syk 20963 P48025 Syk mouse Y520 447662 LRADENyyKAQTHGK PK_Tyr_Ser-Thr X 2711; 2710; 12967; 5514; 4349; 6485; 12081; 46994; 16859 -Syk Syk P48025 mouse PYCARD 66824 Q9EPB4 Pycard mouse Y144 465096 SVLTEGQyQAVRAET CARD X -Syk Syk P48025 mouse CEACAM20 71601 Q9D2Z1 Ceacam20 mouse Y559 41604100 GRNEESNyEKLLNSN X -Syk Syk P48025 mouse Syk 20963 P48025 Syk mouse Y346 447660 TEVyESPyADPEEIR X 2701; 2717; 14791; 73382; 82975; 31754 -Syk Syk P48025 mouse CEACAM20 71601 Q9D2Z1 Ceacam20 mouse Y570 41604101 LNSNHSLyCKITPSA X -PIM3 Pim3 Q86V86 human LDH-A 3939 P00338 LDHA human S161 31882218 PkNrVIGsGCNLDsA X X -PIM3 Pim3 Q86V86 human STAT5B 6777 P51692 STAT5B human S731 448751 TyMDQAPsPAVCPQA X -PIM3 Pim3 Q86V86 human BAD 12015 Q61337 Bad mouse S112 447860 ETRsRHssyPAGtEE Bcl-2_BAD X 9291; 5284; 9296; 5193; 11865; 94223 -PIM3 Pim3 Q86V86 human Myc 4609 P01106 MYC human S308 10852562 GHskPPHsPLVLkrC Myc_N X -PIM3 Pim3 Q86V86 human LDH-A 3939 P00338 LDHA human S319 24986816 EEARLkksADtLWGI Ldh_1_C X -PIM3 Pim3 Q86V86 human BAD 12015 Q61337 Bad mouse S155 447863 GRELRRMsDEFEGsF Bcl-2_BAD X 9297 -PIM3 Pim3 Q86V86 human BAD 572 Q92934 BAD human S75 447860 EIRsRHssyPAGtED Bcl-2_BAD X 9291; 5284; 9296; 5193; 11865; 94223 -PIM3 Pim3 Q86V86 human IRS1 3667 P35568 IRS1 human S1101 453434 GCRRRHssEtFsStP X -PIM3 Pim3 Q86V86 human Notch 1 18128 Q01705 Notch1 mouse S2152 3252805 GkkARkPsTkGLACG X -PIM3 Pim3 Q86V86 human PSMD2 5708 Q13200 PSMD2 human S361 487471 ENNrFGGsGsQVDsA X X -PIM3 Pim3 Q86V86 human BAD 12015 Q61337 Bad mouse S136 447862 PFRGRsRsAPPNLWA Bcl-2_BAD X 9295; 5286; 4366 -LCK Lck P06239 human PRDX1 5052 Q06830 PRDX1 human Y194 448924 DVQkSkEyFskQK__ 1-cysPrx_C X 14041 -LCK Lck P06239 human Syk 20963 P48025 Syk mouse Y317 447658 STVSFNPyEPtGGPW X 2715 -LCK Lck P06239 human CD5 921 P06127 CD5 human Y453 447774 AsHVDNEysQPPRNs X X -LCK Lck P06239 human PLCG2 5336 P16885 PLCG2 human Y753 447940 ERDINSLyDVsRMyV X -LCK Lck P06239 human IL2RB 3560 P14784 IL2RB human Y418 450884 LSGEDDAyCTFPSRD X -LCK Lck P06239 human CD3Z 919 P20963 CD247 human Y142 448932 GkGHDGLyQGLstAt ITAM X 67748 -LCK Lck P06239 human ARHGAP3 1124 P52757 CHN2 human Y153 473503 KMTTNPIyEHIGyAt X -LCK Lck P06239 human ZAP70 7535 P43403 ZAP70 human Y315 448867 MPMDtsVyEsPysDP X -LCK Lck P06239 human CD163L1 338056 P30205 CD163L1 cow Y1326 470034 DALAEAVyEELDYLL X -LCK Lck P06239 human LKB1 20869 Q9WTK7 Stk11 mouse Y365 13258701 DIEDGIIytQDFTVP X -LCK Lck P06239 human SHP-1 5777 P29350 PTPN6 human Y564 448912 sKHkEDVyENLHTkN X X 8849 -LCK Lck P06239 human SHC1 iso2 6464 P29353-2 SHC1 human Y239 448509 EEPPDHQyyNDFPGK X -LCK Lck P06239 human VAV1 7409 P15498 VAV1 human Y142 448809 SVGDEDIySGLSDQI X -LCK Lck P06239 human ZAP70 7535 P43403 ZAP70 human Y474 455368 VLLVNRHyAkISDFG PK_Tyr_Ser-Thr X -LCK Lck P06239 human STAP2 55620 Q9UGK3 STAP2 human Y250 478353 PFLLDEDyEKVLGyV X -LCK Lck P06239 human IL2RB 3560 P14784 IL2RB human Y384 450882 ACQVyFTyDPySEED X -LCK Lck P06239 human TSAd 9047 Q9NP31 SH2D2A human Y280 449440 PKPSNPIyNEPDEPI X -LCK Lck P06239 human VAV1 7409 P15498 VAV1 human Y174 447866 EAEGDEIyEDLMRsE X -LCK Lck P06239 human PIK3R1 282307 P23727 PIK3R1 cow Y368 448134 STKMHGDyTLTLRKG SH2 X -LCK Lck P06239 human BTLA 151888 Q7Z6A9 BTLA human Y257 454099 ENKPGIVyASLNHsV X -LCK Lck P06239 human STAT2 6773 P52630 STAT2 human Y690 448193 NLQERRKyLKHRLIV X 4441; 88410; 77366; 68826; 90740; 23078 -LCK Lck P06239 human CD28 12487 P31041 Cd28 mouse Y207 450284 TRKPYQPyAPARDFA X -LCK Lck P06239 human STAT5A 6776 P42229 STAT5A human Y694 447767 LAkAVDGyVkPQIkQ X 9365; 9356; 9359; 9351; 4322; 9314; 3939; 40284; 5387; 14603; 66740; 51879; 72712 -LCK Lck P06239 human ZAP70 22637 P43404 Zap70 mouse Y318 447587 TSVyESPySDPEELK X 2701; 2717; 14791; 73382; 82975; 31754 -LCK Lck P06239 human SLAM 6504 Q13291 SLAMF1 human Y307 448264 QDPCTTIyVAATEPV X -LCK Lck P06239 human ADAM15 8751 Q13444 ADAM15 human Y715 451223 LVMLGASyWYRARLH TM X -LCK Lck P06239 human LNK 16923 O09039 Sh2b3 mouse Y536 476934 LRAIDNQyTPLSQLC X -LCK Lck P06239 human PLCG2 5336 P16885 PLCG2 human Y1197 447938 LESEEELySSCRQLR X -LCK Lck P06239 human ITGB2 3689 P05107 ITGB2 human Y735 26400600 HLSDLREyRRFEkEK Integrin_b_cyt X -LCK Lck P06239 human ZAP70 7535 P43403 ZAP70 human Y319 447587 tsVyEsPysDPEELk X X 2701; 2717; 14791; 73382; 82975; 31754 -LCK Lck P06239 human VAV1 22324 P27870 Vav1 mouse Y160 447865 AEEDEDLyDCVENEE X -LCK Lck P06239 human DGKA 1606 P23743 DGKA human Y335 486452 ILPPSSIyPSVLASG X X -LCK Lck P06239 human CD3Z 12503 P24161 Cd247 mouse Y123 448934 KDKMAEAysEIGTKG ITAM X -LCK Lck P06239 human SHC1 iso2 6464 P29353-2 SHC1 human Y240 448510 EPPDHQyyNDFPGKE X -LCK Lck P06239 human TSAd 9047 Q9NP31 SH2D2A human Y305 450668 GEAPsNIyVEVEDEG X -LCK Lck P06239 human LKB1 20869 Q9WTK7 Stk11 mouse Y261 13258700 PFEGDNIyKLFENIG Pkinase X -LCK Lck P06239 human PTEN 5728 P60484 PTEN human Y240 448316 RREDKFMyFEFPQPL PTEN_C2 X -LCK Lck P06239 human SOCS3 9021 O14543 SOCS3 human Y221 450447 IREFLDQyDAPL___ X -LCK Lck P06239 human PPP2CA 5515 P67775 PPP2CA human Y307 448571 VTRRtPDyFl_____ X -LCK Lck P06239 human Siglec-10 89790 Q96LC7 SIGLEC10 human Y597 450086 RHstILDyINVVPTA X -LCK Lck P06239 human TSAd 9047 Q9NP31 SH2D2A human Y260 480756 PQLPPEVytIPVPRH X -LCK Lck P06239 human Syk 20963 P48025 Syk mouse Y342 447659 LPMDTEVyESPyADP X -LCK Lck P06239 human IL2RB 3560 P14784 IL2RB human Y381 450881 EIEACQVyFTyDPyS X -LCK Lck P06239 human THEMIS 387357 Q8N1K5 THEMIS human Y429 27806312 EAALLPLyMEGGFVE CABIT X -LCK Lck P06239 human CBL 867 P22681 CBL human Y774 448531 sENEDDGyDVPKPPV X 3555 -LCK Lck P06239 human THEMIS 387357 Q8N1K5 THEMIS human Y540 27806313 EEITEEQyyMMRRYE X X -LCK Lck P06239 human LAX1 54900 Q8IWV1 LAX1 human Y373 460158 SNEDSSDyENVLTAK LAX X -LCK Lck P06239 human ITK 3702 Q08881 ITK human Y512 447997 RFVLDDQytsstGtk PK_Tyr_Ser-Thr X X -LCK Lck P06239 human TBK1 29110 Q9UHD2 TBK1 human Y354 3437786 SSNQELIyEGRRLVL TBK1_ULD X -LCK Lck P06239 human Lck 3932 P06239 LCK human Y394 447822 RLIEDNEytAREGAk PK_Tyr_Ser-Thr X X 2101; 6943; 59548; 70926; 78740; 94361; 17320 -LCK Lck P06239 human CD3Z 12503 P24161 Cd247 mouse Y72 448936 LQDPNQLyNELNLGR ITAM X -LCK Lck P06239 human ZAP70 7535 P43403 ZAP70 human Y69 447588 ERQLNGTyAIAGGkA SH2 X -LCK Lck P06239 human THEMIS 387357 Q8N1K5 THEMIS human Y95 27806315 IVADkTPyLTMEEIT CABIT X -LCK Lck P06239 human SLP76 3937 Q13094 LCP2 human Y128 448219 DGEDDGDyEsPNEEE X -LCK Lck P06239 human SLC25A4 291 P12235 SLC25A4 human Y195 457913 RAAyFGVyDtAkGML TM; Mito_carr X -LCK Lck P06239 human LAX1 54900 Q8IWV1 LAX1 human Y193 35546000 SSEDSHDyVNVPTAE LAX X -LCK Lck P06239 human CD3Z 12503 P24161 Cd247 mouse Y142 448932 GKGHDGLyQGLsTAT ITAM X X -LCK Lck P06239 human TSAd 9047 Q9NP31 SH2D2A human Y290 449441 PDEPIAFyAMGrGsP X -LCK Lck P06239 human MED28 80306 Q9H204 MED28 human Y64 466940 ASLVSQDyVNGTDQE Med28 X X -LCK Lck P06239 human SHC1 iso2 6464 P29353-2 SHC1 human Y317 448511 ELFDDPSyVNVQNLD X -LCK Lck P06239 human SSBP3 23648 Q9BWW4 SSBP3 human Y25 1806901 EkLALyVyEYLLHVG X -LCK Lck P06239 human VAV1 22324 P27870 Vav1 mouse Y142 448809 ALNDEDIySGLSDQI X -LCK Lck P06239 human CD33 945 P20138 CD33 human Y340 450952 EMDEELHyASLNFHG X -LCK Lck P06239 human CCDC50 152137 Q8IVM0 CCDC50 human Y304 6377636 SSHkGFHyKH_____ X -LCK Lck P06239 human ZAP70 7535 P43403 ZAP70 human Y493 447505 LGADDsyytARsAGk PK_Tyr_Ser-Thr X X 2704 -LCK Lck P06239 human Lck 3932 P06239 LCK human Y505 447823 FTAtEGQyQPQP___ X X 2751; 37458 -LCK Lck P06239 human LAX1 54900 Q8IWV1 LAX1 human Y268 35546002 SSQISNDyVNMTGLD LAX X -LCK Lck P06239 human VAV1 7409 P15498 VAV1 human Y160 447865 VEEDEDLyDCVENEE X -LCK Lck P06239 human IL2RB 3560 P14784 IL2RB human Y536 450934 LPLNTDAyLSLQELQ X -LCK Lck P06239 human PLCG2 5336 P16885 PLCG2 human Y759 447941 LyDVsRMyVDPsEIN X 3874; 50535 -LCK Lck P06239 human SLP76 3937 Q13094 LCP2 human Y145 448220 PVEDDADyEPPPSND X 14770; 16796 -LCK Lck P06239 human ZAP70 7535 P43403 ZAP70 human Y178 447590 EEAERkLysGAQTDG SH2 X -LCK Lck P06239 human BTLA 151888 Q7Z6A9 BTLA human Y226 1869334004 LLSETGIyDNDPDLC X -LCK Lck P06239 human PECAM-1 5175 P16284 PECAM1 human Y713 448760 KKDtEtVysEVRKAV X -LCK Lck P06239 human SSBP3 23648 Q9BWW4 SSBP3 human Y23 1806900 AREkLALyVyEYLLH X -LCK Lck P06239 human CD3Z 12503 P24161 Cd247 mouse Y153 455204 sTATKDtyDALHMQT ITAM X -LCK Lck P06239 human KSR 16706 Q61097 Ksr1 mouse Y728 3428057 LSHDWLCyLAPEIVR PK_Tyr_Ser-Thr X -LCK Lck P06239 human THEMIS 387357 Q8N1K5 THEMIS human Y541 27806310 EITEEQyyMMRRYES X X -LCK Lck P06239 human P38A 1432 Q16539 MAPK14 human Y323 455799 DEPVADPyDQsFESR X -LCK Lck P06239 human PIK3R1 282307 P23727 PIK3R1 cow Y688 448137 FAEPYNLySSLKELV SH2 X -LCK Lck P06239 human ZAP70 7535 P43403 ZAP70 human Y492 447504 ALGADDsyytARsAG PK_Tyr_Ser-Thr X X -LCK Lck P06239 human SHP-1 5777 P29350 PTPN6 human Y536 448506 QkGQEsEyGNItyPP X -LCK Lck P06239 human IL2RB 3560 P14784 IL2RB human Y387 450883 VyFTyDPySEEDPDE X -LCK Lck P06239 human CD3Z 12503 P24161 Cd247 mouse Y83 449322 NLGRREEyDVLEKKR ITAM X -LCK Lck P06239 human CBL 867 P22681 CBL human Y700 448529 EGEEDtEyMtPssRP X 8869 -LCK Lck P06239 human PTEN 5728 P60484 PTEN human Y315 448317 RADNDKEyLVLtLtK PTEN_C2 X -LCK Lck P06239 human PKCT 5588 Q04759 PRKCQ human Y90 448588 SETTVELySLAERCR X X -LCK Lck P06239 human SENP1 29843 Q9P0U3 SENP1 human Y270 1876335002 EQLSHSVySLSSYTP X -LCK Lck P06239 human CD5 921 P06127 CD5 human Y487 447775 DNssDsDyDLHGAQR X X -LCK Lck P06239 human DLG1 13383 Q811D0 Dlg1 mouse Y222 35530400 GTDADYEyEEITLER MAGUK_N_PEST X -LCK Lck P06239 human ACP1 52 P24666 ACP1 human Y132 450718 QLIIEDPyyGNDsDF LMWPc X -LCK Lck P06239 human ER-alpha 2099 P03372 ESR1 human Y537 448103 CKNVVPLyDLLLEML X -LCK Lck P06239 human SPTAN1 64159 P16086 Sptan1 rat Y1176 448817 AVQQQEVyGMMPRDE X -LCK Lck P06239 human Siglec-10 89790 Q96LC7 SIGLEC10 human Y667 450087 ESQEELHyATLNFPG X -LCK Lck P06239 human TIGIT 201633 Q495A1 TIGIT human Y225 27266400 DCAELHDyFNVLSYR X -LCK Lck P06239 human THEMIS 387357 Q8N1K5 THEMIS human Y174 27806311 LsQEGEFyECEDERI CABIT X -LCK Lck P06239 human IkB-alpha 4792 P25963 NFKBIA human Y42 448737 DsMkDEEyEQMVkEL X X -LCK Lck P06239 human BTLA 151888 Q7Z6A9 BTLA human Y282 463077 VKEAPtEyASICVRS X -LCK Lck P06239 human CD28 12487 P31041 Cd28 mouse Y189 450282 NRLLQSDyMNMTPRR X 16399 -LCK Lck P06239 human TRPM8 171384 Q8R455 Trpm8 rat Y1022 1877492902 FVVFAYFyMVVKKCF X X -LCK Lck P06239 human G3BP-1 10146 Q13283 G3BP1 human Y56 454080 GkPADAVyGQkEIHR NTF2 X X -LCK Lck P06239 human CCDC50 152137 Q8IVM0 CCDC50 human Y279 462101 tDGEDADytHFtNQQ X -LCK Lck P06239 human BTLA 151888 Q7Z6A9 BTLA human Y243 1869334003 MQEGSEVySNPCLEE X -LCK Lck P06239 human LAX1 54900 Q8IWV1 LAX1 human Y294 35546001 AFQCCRDyENVPAAD LAX X -LCK Lck P06239 human CCDC50 152137 Q8IVM0 CCDC50 human Y217 6377637 MAEEkKAykkAkERE X -LCK Lck P06239 human SOCS3 9021 O14543 SOCS3 human Y204 450446 VNGHLDSyEkVTQLP X -LCK Lck P06239 human CBL 867 P22681 CBL human Y731 448530 QQIDSCTyEAMyNIQ X 3554 -LCK Lck P06239 human ZAP70 7535 P43403 ZAP70 human Y126 447589 RDAMVRDyVRQTWkL X -LCK Lck P06239 human ZAP70 7535 P43403 ZAP70 human Y292 447586 DtLNsDGytPEPARI X -LCK Lck P06239 human Ezrin 7430 P15311 EZR human Y146 448758 kEVHksGyLSsERLI FERM_M X -LCK Lck P06239 human Siglec-10 89790 Q96LC7 SIGLEC10 human Y691 450088 PKGTQADyAEVKFQ_ X -LCK Lck P06239 human WASP 7454 P42768 WAS human Y291 447985 AEtsKLIyDFIEDQG PBD X -LCK Lck P06239 human SLP76 3937 Q13094 LCP2 human Y113 448218 ssFEEDDyESPNDDQ X -LCK Lck P06239 human Lck 16818 P06240 Lck mouse Y394 447822 RLIEDNEytAREGAK PK_Tyr_Ser-Thr X 2101; 6943; 59548; 70926; 78740; 94361; 17320 -LCK Lck P06239 human LKB1 20869 Q9WTK7 Stk11 mouse Y36 14575494 IDstEVIyQPRRKRA X -LCK Lck P06239 human CD3Z 12503 P24161 Cd247 mouse Y111 448933 RNPQEGVyNALQKDK ITAM X -LCK Lck P06239 human Syk 20963 P48025 Syk mouse Y346 447660 TEVyESPyADPEEIR X X 2701; 2717; 14791; 73382; 82975; 31754 -LCK Lck P06239 human ACP1 52 P24666 ACP1 human Y133 457445 LIIEDPyyGNDsDFE LMWPc X -LCK Lck P06239 human TBK1 29110 Q9UHD2 TBK1 human Y394 126839800 LNTIGLIyEkISLPk TBK1_ULD X -LCK Lck P06239 human THEMIS 387357 Q8N1K5 THEMIS human Y353 27806314 PREFPTAyDLEIAkS CABIT X -LCK Lck P06239 human DAPP1 27071 Q9UN19 DAPP1 human Y139 448325 kVEEPsIyEsVRVHT X X 13703 -LCK Lck P06239 human VAV1 22324 P27870 Vav1 mouse Y174 447866 EAEGDEIyEDLMRLE X -LCK Lck P06239 human PLCG2 5336 P16885 PLCG2 human Y1217 447939 LNNQLFLyDtHQNLR X 3871 -LCK Lck P06239 human FOXP3 50943 Q9BZS1 FOXP3 human Y342 29606712 NMRPPFTyATLIRWA Forkhead X X -EPHA1 EphA1 P21709 human GJB1 2705 P08034 GJB1 human Y243 3559630 GHRLsPEyKQNEINk X X -MST1R Ron Q04912 human Abl 25 P00519 ABL1 human Y393 450298 RLMtGDtytAHAGAk PK_Tyr_Ser-Thr X 2865 -MST1R Ron Q04912 human Met 4233 P08581 MET human Y1349 448472 stFIGEHyVHVNAty X 3133; 3121 -MST1R Ron Q04912 human Abl 25 P00519 ABL1 human Y226 450303 KRNKPtVyGVsPNyD X 2868; 2861 -MST1R Ron Q04912 human GJB1 2705 P08034 GJB1 human Y243 3559630 GHRLsPEyKQNEINk X -MST1R Ron Q04912 human Met 4233 P08581 MET human Y1356 448473 yVHVNAtyVNVKCVA X -MST1R Ron Q04912 human Met 4233 P08581 MET human Y1234 448470 RDMyDkEyysVHNkt PK_Tyr_Ser-Thr X 4091; 3129; 3126; 3077; 12468; 4033; 98954 -MST1R Ron Q04912 human Met 4233 P08581 MET human Y1235 448471 DMyDkEyysVHNktG PK_Tyr_Ser-Thr X 4091; 3129; 3126; 3077; 12468; 4033; 98954 -Prkaa2 AMPKA2 Q8BRK8 mouse beclin 1 56208 O88597 Becn1 mouse S91 5473540 ARMMsTEsANsFTLI X 14717 -Prkaa2 AMPKA2 Q8BRK8 mouse AP-2 alpha 21418 P34056 Tfap2a mouse S219 25581601 CSVPGRLsLLSSTSK TF_AP-2 X -Prkaa2 AMPKA2 Q8BRK8 mouse IKKB 16150 O88351 Ikbkb mouse S181 447489 DQGsLCTsFVGTLQy Pkinase X 2697; 2694; 14938; 92255; 36516; 36214 -Prkaa2 AMPKA2 Q8BRK8 mouse ACC1 107476 Q5SWU9 Acaca mouse S79 448292 FHMRSsMsGLHLVKQ X 3661; 11818; 42801 -Prkaa2 AMPKA2 Q8BRK8 mouse TBC1D17 233204 Q8BYH7 Tbc1d17 mouse S168 1873559800 RALLRVLsRYLLLAS PH_RBD X -Prkaa2 AMPKA2 Q8BRK8 mouse ACE2 70008 Q8R0I0 Ace2 mouse S680 1868162500 SDLKPRVsFYFFVTS Collectrin X -Prkaa2 AMPKA2 Q8BRK8 mouse IKKB 16150 O88351 Ikbkb mouse S177 447492 AKELDQGsLCTsFVG Pkinase X 2078; 2697; 2694; 14938; 92255; 36516; 36214 -Prkaa2 AMPKA2 Q8BRK8 mouse ULK1 22241 O70405 Ulk1 mouse S555 3176155 GLGCRLHsAPNLSDF X 5869 -Prkaa2 AMPKA2 Q8BRK8 mouse p53 22059 P02340 Tp53 mouse S18 447490 IsLELPLsQEtFsGL P53_TAD X 9284; 9286; 12571; 56979 -Prkaa2 AMPKA2 Q8BRK8 mouse PD-L1 29126 Q9NZQ7 CD274 human S283 14735979 DTNsKkQsDtHLEEt X -Prkaa2 AMPKA2 Q8BRK8 mouse GFAT 14583 P47856 Gfpt1 mouse S259 467935 CGLsRVDsttCLFPV X X -Prkaa2 AMPKA2 Q8BRK8 mouse AS160 210789 Q8BYJ6 Tbc1d4 mouse S711 2226513 PSLHTSFsAPSFTAP X -Stk24 MST3 Q99KH8 mouse RHOA 11848 Q9QUI0 Rhoa mouse S26 484601 tCLLIVFsKDQFPEV Ras X -RET Ret iso3 Q15300 human STAT3 6774 P40763 STAT3 human Y705 448192 DPGsAAPyLktKFIC X 4093; 9145; 4324; 9131; 9138; 4323; 4074; 4113; 48313; 20977; 25023; 8119; 52075; 52527; 73533; 61958; 73452; 16185; 74309 -RET Ret iso3 Q15300 human Ret iso3 5979 Q15300 RET human Y586 447625 TWIENKLyGRISHAF X -Prkab1 AMPKB1 Q9R078 mouse STIM1 20866 P70302 Stim1 mouse S257 468872 GLHRAEQsLHDLQER X -Prkab1 AMPKB1 Q9R078 mouse STIM1 20866 P70302 Stim1 mouse S521 468874 rDLtHsDsEssLHMs X -UHMK1 KIS Q8TAS1 human FAM64A 54478 Q9BSJ6 PIMREG human S131 14573437 GAQKGsGsPtHsLsQ RCS1 X X -UHMK1 KIS Q8TAS1 human STMN1 3925 P16949 STMN1 human S38 448556 sVPEFPLsPPkKkDL Stathmin X 3426; 4191 -UHMK1 KIS Q8TAS1 human SRC-3 8202 Q9Y6Q9 NCOA3 human S1062 4252805 DQLHtLLsNtDAtGL Nuc_rec_co-act X X -UHMK1 KIS Q8TAS1 human SF1 7536 Q15637 SF1 human S80 452434 PPNPEDRsPsPEPIy SF1-HH X X -UHMK1 KIS Q8TAS1 human p27Kip1 1027 P46527 CDKN1B human S10 447874 NVRVSNGsPsLErMD X X -UHMK1 KIS Q8TAS1 human SRC-3 8202 Q9Y6Q9 NCOA3 human T1067 4252800 LLsNtDAtGLEEIDR Nuc_rec_co-act X X -UHMK1 KIS Q8TAS1 human SF1 7536 Q15637 SF1 human S82 452435 NPEDRsPsPEPIyNs SF1-HH X X -Mst1r Ron Q62190 mouse Ron 19882 Q62190 Mst1r mouse Y1294 456484 EYCPDSLyHVMLRCW PK_Tyr_Ser-Thr X -Mst1r Ron Q62190 mouse Ron 19882 Q62190 Mst1r mouse Y1265 456483 LTRGAPPyPHIDPFD PK_Tyr_Ser-Thr X -Mst1r Ron Q62190 mouse Ron 19882 Q62190 Mst1r mouse Y1175 456482 QVACGMEyLAEQKFV PK_Tyr_Ser-Thr X -PHKG1 PHKG1 Q16816 human GAP43 281777 P06836 GAP43 cow S41 448719 AATKIQAsFRGHITR IQ X -PHKG1 PHKG1 Q16816 human neurogranin 616955 P35722 NRGN cow S36 455913 AAAKIQAsFRGHMAR IQ X -Prkg2 PKG2 Q64595 rat PLCB3 29322 Q99JE6 Plcb3 rat S1105 448448 LDRKRNNsISEAKTR PLC-beta_C X X 2484 -Prkg2 PKG2 Q64595 rat PKG2 25523 Q64595 Prkg2 rat S110 450474 LDVHRKTsGLVsLHs X -Prkg2 PKG2 Q64595 rat PKG2 25523 Q64595 Prkg2 rat S445 450476 KEKVARFsSTSPFQN X -Prkg2 PKG2 Q64595 rat PKG2 25523 Q64595 Prkg2 rat S114 450475 RKTsGLVsLHsRRGA X -Prkg2 PKG2 Q64595 rat PLCB3 29322 Q99JE6 Plcb3 rat S26 448449 VETLRRGsKFIKWDE PH_14 X X -Cdk9 CDK9 Q641Z4 rat POLR2A 363633 D4A5A6 Polr2a rat S1616 450204 TPQSPSYsPTsPSYS RNA_pol_Rpb1_R X 4735; 13499; 13546; 31262 -Ulk1 ULK1 O70405 mouse beclin 1 56208 O88597 Becn1 mouse S14 25268704 SSSTMQVsFVCQRCS X X 84966 -Ulk1 ULK1 O70405 mouse RAB9A 56382 Q9R0M6 Rab9a mouse S179 3191548 ILAtEDRsEHLIQTD X X -Ulk1 ULK1 O70405 mouse FUNDC1 72018 Q9DB70 Fundc1 mouse S17 2025377 DyEsDDEsyEVLDLT X -IKBKE IKKE Q14164 human PELI1 57162 Q96FA3 PELI1 human T80 7388010 DQHsIsYtLsRAQtV Pellino X -IKBKE IKKE Q14164 human NFAT2 4772 O95644 NFATC1 human S324 56629003 NALTTDSsLDLGDGV X -IKBKE IKKE Q14164 human IRF3 3661 Q14653 IRF3 human S386 448684 ARVGGAssLENtVDL X X 37829; 73981; 96421; 91968 -IKBKE IKKE Q14164 human TRAF3IP2 103213 Q8N7N6 Traf3ip2 mouse S222 25687505 DLPGPLRsRELPPQF X X -IKBKE IKKE Q14164 human IRF1 3659 P10914 IRF1 human S219 31839600 FQVsPMPsTsEATTD X X -IKBKE IKKE Q14164 human PELI1 57162 Q96FA3 PELI1 human T288 7388016 QCPVGFNtLAFPsMk Pellino X -IKBKE IKKE Q14164 human IRF7 3665 Q92985 IRF7 human S477 1276101 VssLDSSsLsLCLsS X X 12390 -IKBKE IKKE Q14164 human STAT1 20846 P42225 Stat1 mouse S708 7723201 yIkTELIsVSEVHPS X -IKBKE IKKE Q14164 human Akt1 207 P31749 AKT1 human S473 447855 RPHFPQFsysAsGtA Pkinase_C X X 9271; 3787; 4060; 4051; 5102; 4058; 2336; 2337; 4075; 4070; 5012; 4071; 92982; 5315; 9563; 9018; 12694; 52240; 11962; 15116; 88106; 26580; 68035; 31957; 23430; 20235 -IKBKE IKKE Q14164 human IRF1 3659 P10914 IRF1 human S215 31839602 DLYNFQVsPMPsTsE X X -IKBKE IKKE Q14164 human NFAT2 4772 O95644 NFATC1 human S151 56629000 VLPSSKRsPstATLs X -IKBKE IKKE Q14164 human IRF3 3661 Q14653 IRF3 human S398 449029 VDLHIsNsHPLsLts X -IKBKE IKKE Q14164 human CDK2AP1 8099 O14519 CDK2AP1 human S46 25126700 LSDYGPPsLGYTQGT CDK2AP X -IKBKE IKKE Q14164 human IRF1 3659 P10914 IRF1 human S221 31839601 VsPMPsTsEATTDED X X -IKBKE IKKE Q14164 human YAP1 10413 P46937 YAP1 human S419 31884052 tPDDFLNsVDEMDTG X X -IKBKE IKKE Q14164 human DDX3 1654 O00571 DDX3X human S102 11183059 rFDDrGrsDyDGIGs X X -IKBKE IKKE Q14164 human PBXIP1 57326 Q96AQ6 PBXIP1 human S147 471206 REEGRCsssDDDtDV X -IKBKE IKKE Q14164 human NFkB-p65 5970 Q04206 RELA human S536 447800 sGDEDFSsIADMDFS X X 4887; 3036; 3031; 4886; 3033; 4025; 5733; 13346; 76778; 31553; 80477; 73992; 87672; 83962 -IKBKE IKKE Q14164 human IRF7 3665 Q92985 IRF7 human S479 2868600 sLDSSsLsLCLsSAN X X -IKBKE IKKE Q14164 human NFkB-p65 5970 Q04206 RELA human S468 451145 AVFTDLAsVDNsEFQ X X 3039 -IKBKE IKKE Q14164 human IKKE 9641 Q14164 IKBKE human T501 34434402 ELRSRLRtLAEVLSR TBK1_CCD1 X X -IKBKE IKKE Q14164 human IRF3 3661 Q14653 IRF3 human S402 449030 IsNsHPLsLtsDQYK X X -IKBKE IKKE Q14164 human STAT1 20846 P42225 Stat1 mouse S744 7723202 IVGPEFDsMMsTV__ X -IKBKE IKKE Q14164 human TRAF3IP2 103213 Q8N7N6 Traf3ip2 mouse S209 25687506 ERPLPLTsSCYLQDL X X -IKBKE IKKE Q14164 human IkB-alpha 4792 P25963 NFKBIA human S32 448203 LLDDRHDsGLDsMkD X 5210; 2859; 9246; 5209 -IKBKE IKKE Q14164 human FOXO3A 2309 O43524 FOXO3 human S644 451438 GLDFNFDsLISTQNV FOXO-TAD X X -IKBKE IKKE Q14164 human GSK3A 2931 P49840 GSK3A human S21 448584 sGrARtssFAEPGGG X 9337; 9316; 9331; 5090; 9327; 8452; 8566 -IKBKE IKKE Q14164 human ASB8 140461 Q9H765 ASB8 human S17 1869062300 QSIQSKYsLSERLIR X -IKBKE IKKE Q14164 human IkB-alpha 4792 P25963 NFKBIA human S36 448204 RHDsGLDsMkDEEyE X 5210; 9246 -IKBKE IKKE Q14164 human Snail1 20613 Q02085 Snai1 mouse S165 1876128600 YCNKEYLsLGALKMH zf-C2H2_6 X -IKBKE IKKE Q14164 human Huntingtin 3064 P42858 HTT human S13 10206805 kLMkAFEsLksFQQQ X -IKBKE IKKE Q14164 human IRF3 3661 Q14653 IRF3 human S396 449028 NtVDLHIsNsHPLsL X X 4947; 29047; 83611; 10327; 53539; 81093; 52270; 61166 -IKBKE IKKE Q14164 human TRAF2 7186 Q12933 TRAF2 human S11 5397201 AsVtPPGsLELLQPG X 13908 -IKBKE IKKE Q14164 human IRF7 3665 Q92985 IRF7 human S471 1276102 GTQREGVssLDSSsL X 5184 -IKBKE IKKE Q14164 human RIGI 23586 O95786 RIGI human S855 17484201 PKPkQFssFEkRAKI RIG-I_C-RD X -IKBKE IKKE Q14164 human NFAT2 4772 O95644 NFATC1 human S161 56629001 tATLsLPsLEAYRDP X X -IKBKE IKKE Q14164 human kindlin-2 10979 Q96AC1 FERMT2 human S159 3208605 KkkLDDQsEDEALEL X X -IKBKE IKKE Q14164 human ER-alpha 2099 P03372 ESR1 human S167 448102 GGRERLAsTNDkGSM Oest_recep X X 64508; 42101 -IKBKE IKKE Q14164 human NFAT2 4772 O95644 NFATC1 human S117 56629002 DGAPALEsPRIEITS X -IKBKE IKKE Q14164 human CYLD 74256 Q80TQ2 Cyld mouse S414 4745557 SSENRFHsLPFsLtK CYLD_phos_site X -IKBKE IKKE Q14164 human IRF7 3665 Q92985 IRF7 human S472 1276103 TQREGVssLDSSsLs X 5184 -IKBKE IKKE Q14164 human TRAF3IP2 103213 Q8N7N6 Traf3ip2 mouse S311 21041604 KVILNDSsPQDQEER X -IKBKE IKKE Q14164 human STAT1 20846 P42225 Stat1 mouse S747 7723200 PEFDsMMsTV_____ X -IKBKE IKKE Q14164 human PELI1 57162 Q96FA3 PELI1 human S293 7388014 FNtLAFPsMkRkDVV Pellino X -IKBKE IKKE Q14164 human XIAP 331 P98170 XIAP human S430 22547400 QDESSQtsLQkEIst X X -IKBKE IKKE Q14164 human NFkB-p65 19697 Q04207 Rela mouse S534 447800 sGDEDFssIADMDFS X 4887; 3036; 3031; 4886; 3033; 4025; 5733; 13346; 76778; 31553; 80477; 73992; 87672; 83962 -IKBKE IKKE Q14164 human PELI1 57162 Q96FA3 PELI1 human S76 7388015 IsNKDQHsIsYtLsR Pellino X -IKBKE IKKE Q14164 human STAT2 6773 P52630 STAT2 human T404 1869973803 IWDFGYLtLVEQRSG STAT_bind X X -IKBKE IKKE Q14164 human TRAF3IP2 103213 Q8N7N6 Traf3ip2 mouse S147 25687507 ESDKSDPsLPNALAD X X -IKBKE IKKE Q14164 human Akt1 207 P31749 AKT1 human T308 447856 kDGAtMKtFCGtPEy Pkinase X X 5106; 2965; 9275; 4056; 5056; 13842; 13038; 43506; 48646; 86758; 80722; 77440; 80556 -IKBKE IKKE Q14164 human FAF1 11124 Q9UNN5 FAF1 human S556 27996217 EREAIRLsLEQALPP X X -Btk Btk P35991 mouse Ikaros 22778 Q03267 Ikzf1 mouse S213 28735108 GRSYKQRssLEEHKE zf-C2H2 X -Btk Btk P35991 mouse Btk 12229 P35991 Btk mouse Y551 447486 RYVLDDEyTsSVGSK PK_Tyr_Ser-Thr X 69360; 18805; 64137; 16803 -Btk Btk P35991 mouse Ikaros 22778 Q03267 Ikzf1 mouse S214 28735107 RSYKQRssLEEHKER zf-C2H2 X -Btk Btk P35991 mouse Btk 695 Q06187 BTK human Y223 447485 LKKVVALyDyMPMNA SH3_1 X 5082; 87141; 87457 -Btk Btk P35991 mouse IFNGR2 15980 Q63953 Ifngr2 mouse Y289 1341879204 IPEQIEEyLKDPDQF X X -Btk Btk P35991 mouse STAT5A 20850 P42230 Stat5a mouse Y694 447767 LAKAVDGyVkPQIKQ X 9365; 9356; 9359; 9351; 4322; 9314; 3939; 40284; 5387; 14603; 66740; 51879; 72712 -Btk Btk P35991 mouse Btk 12229 P35991 Btk mouse Y375 457681 GLISRLKyPVSKQNK X -Btk Btk P35991 mouse Btk 12229 P35991 Btk mouse Y617 454022 IAQGLRLyRPHLAsE PK_Tyr_Ser-Thr X - Fyn no information G6PD 2539 P11413 G6PD human Y503 454849 MkRVGFQyEGtykWV G6PD_C X -MAPK12 P38G P53778 human MyoD 4654 P15172 MYOD1 human S201 40684505 SGDSDAssPRsNCsD Myf5 X -MAPK12 P38G P53778 human ATF-2 1386 P15336 ATF2 human T71 448225 IVADQtPtPtRFLkN X 9225; 9221; 5112; 94125; 13850; 40749; 15411; 24329; 61584; 27934; 92109; 20534; 35858 -MAPK12 P38G P53778 human PSD-95 29495 P31016 Dlg4 rat T287 469607 TDyPtAMtPTsPRRY PDZ_assoc X -MAPK12 P38G P53778 human NUP62 23636 P37198 NUP62 human T269 36440512 GAASGTStTTsTAAT X X -MAPK12 P38G P53778 human DLG1 1739 Q12959 DLG1 human S443 5931300 FLGQtPAsPARysPV PDZ_assoc X -MAPK12 P38G P53778 human Tau iso8 4137 P10636-8 MAPT human S396 449081 GAEIVyKsPVVsGDt X 9632 -MAPK12 P38G P53778 human Tau iso8 4137 P10636-8 MAPT human S404 449082 PVVsGDtsPRHLsNV X 35834; 20194; 98523; 91600; 49562 -MAPK12 P38G P53778 human DLG1 1739 Q12959 DLG1 human T209 35547401 VNTDSLEtPTYVNGT MAGUK_N_PEST X -MAPK12 P38G P53778 human STAT2 6773 P52630 STAT2 human Y690 448193 NLQERRKyLKHRLIV X 4441; 88410; 77366; 68826; 90740; 23078 -MAPK12 P38G P53778 human PTPN3 5774 P26045 PTPN3 human S459 25594501 QKSsSSVsPSSNAPG X X -MAPK12 P38G P53778 human HTRA2 27429 O43464 HTRA2 human S142 487466 VPSPPPAsPRSQYNF Peptidase_M50 X -MAPK12 P38G P53778 human HSP90A 3320 P07900 HSP90AA1 human S595 31909111 VsNRLVTsPCCIVts HSP90 X X -MAPK12 P38G P53778 human NUP62 23636 P37198 NUP62 human S272 36440511 SGTStTTsTAATATA X X -MAPK12 P38G P53778 human p53 7157 P04637 TP53 human S33 447531 LPENNVLsPLPsQAM X X 2526 -MAPK12 P38G P53778 human SH3BP5 117186 Q91Y80 Sh3bp5 rat S353 456020 PGSLDLPsPVSLSEF X -MAPK12 P38G P53778 human P38G 6300 P53778 MAPK12 human S3 11380200 _____MSsPPPARSG X -MAPK12 P38G P53778 human SQSTM1 8878 Q13501 SQSTM1 human T269 457004 GGkRsRLtPVsPEss X 13121 -MAPK12 P38G P53778 human SREBP-1 6720 P36956 SREBF1 human S63 23940711 AGGtDPAsPDTSSPG X -MAPK12 P38G P53778 human SREBP-1 6720 P36956 SREBF1 human T426 467200 TEVEDTLtPPPsDAG X -MAPK12 P38G P53778 human CCND3 896 P30281 CCND3 human T283 452160 QGPsQtstPtDVtAI X 53966 -MAPK12 P38G P53778 human DLG1 25252 Q62696 Dlg1 rat T209 35547401 VNTDSLEtPTYVNGT MAGUK_N_PEST X -MAPK12 P38G P53778 human GYS1 2997 P13807 GYS1 human S723 4787599 sssLStPsEPLsPts X -MAPK12 P38G P53778 human HSF1 3297 Q00613 HSF1 human S307 449046 EPPsPPQsPRVEEAs Vert_HS_TF X -MAPK12 P38G P53778 human CTNNB1 1499 P35222 CTNNB1 human S605 3545003 LFVQLLYsPIENIQR Arm X X -MAPK12 P38G P53778 human MyoD 4654 P15172 MYOD1 human S200 452000 YSGDSDAssPRsNCs Myf5 X -MAPK12 P38G P53778 human DLG1 1739 Q12959 DLG1 human S158 2024309 FVsHsHIsPIKPTEA MAGUK_N_PEST X -MAPK12 P38G P53778 human DLG1 25252 Q62696 Dlg1 rat S442 5931300 YLGQTPAsPARYsPI PDZ_assoc X -MAPK12 P38G P53778 human Tau 17762 P10637 Mapt mouse T497 447933 ssPGsPGtPGsRsRt X 25377; 43964; 53001; 49561; 20060; 33032; 30505; 20739; 98160 -MAPK12 P38G P53778 human NALP1 22861 Q9C000 NLRP1 human S107 1880261804 PSEPHLGsPSQPTST X -MAPK12 P38G P53778 human MEF2D 4209 Q14814 MEF2D human S444 449407 SIkSEPVsPsRERsP X -MAPK12 P38G P53778 human HSF1 3297 Q00613 HSF1 human S303 449045 RVkEEPPsPPQsPRV Vert_HS_TF X -MAPK12 P38G P53778 human Tip60 iso2 10524 Q92993-2 KAT5 human T106 10800707 VEVVsPAtPVPSETA X -MAPK12 P38G P53778 human DLG1 25252 Q62696 Dlg1 rat S158 2024309 FVSHSHIsPIKPTEA MAGUK_N_PEST X -MAPK12 P38G P53778 human GYS1 2997 P13807 GYS1 human S727 457615 StPsEPLsPtssLGE X -MAPK12 P38G P53778 human HSF1 3297 Q00613 HSF1 human S326 455484 ssVDtLLsPTALIDs Vert_HS_TF X X -MAPK12 P38G P53778 human GYS1 2997 P13807 GYS1 human T278 1875332700 kRkPDIVtPNGLNVk Glycogen_syn X -MAPK12 P38G P53778 human SQSTM1 8878 Q13501 SQSTM1 human S272 454787 RsRLtPVsPEssstE X 13121 -MAPK12 P38G P53778 human PSD-95 29495 P31016 Dlg4 rat S290 469608 PtAMtPTsPRRYsPV PDZ_assoc X -MAPK12 P38G P53778 human Tip60 10524 Q92993 KAT5 human T158 10800707 VEVVsPAtPVPSETA X -Eif2ak3 PERK Q9Z2B5 mouse PERK 13666 Q9Z2B5 Eif2ak3 mouse T980 447936 MPAYATHtGQVGTKL Pkinase X 3179 -Eif2ak3 PERK Q9Z2B5 mouse eIF2-alpha 13665 Q6ZWX6 Eif2s1 mouse S52 447635 MILLSELsRrrIRSI S1 X 3597; 9721; 3398; 5199; 53085; 95797 -Eif2ak3 PERK Q9Z2B5 mouse eIF2-alpha 1965 P05198 EIF2S1 human S52 447635 MILLsELsRRRIRsI S1 X 3597; 9721; 3398; 5199; 53085; 95797 -MAP2K4 MKK4 P45985 human JNK1 iso2 5599 P45983-2 MAPK8 human Y185 447645 TSFMMtPyVVTRYYR Pkinase X 5136; 9255; 9251; 4306; 5755; 16014 -MAP2K4 MKK4 P45985 human JNK2 5601 P45984 MAPK9 human Y185 447652 tNFMMtPyVVtRYYR Pkinase X X -MAP2K4 MKK4 P45985 human JNK1 5599 P45983 MAPK8 human Y185 447645 tsFMMtPyVVtRYYR Pkinase X X 5136; 4668; 4671; 9257; 9255; 9251; 4306; 5755; 16014; 58328 -MAP2K4 MKK4 P45985 human RXRA 6256 P19793 RXRA human Y249 456812 VEPKTETyVEANMGL X -MAP2K4 MKK4 P45985 human JNK3 5602 P53779 MAPK10 human Y223 448035 tsFMMtPyVVtRYYR Pkinase X 4668; 58328 -MAP2K4 MKK4 P45985 human MKK4 6416 P45985 MAP2K4 human S257 447654 ISGQLVDsIAKtRDA Pkinase X 9156; 4514; 59056; 75450 -MAP2K4 MKK4 P45985 human JNK2 26420 Q9WTU6 Mapk9 mouse T183 447649 ACTNFMMtPyVVtRY Pkinase X -MAP2K4 MKK4 P45985 human JNK1 iso3 5599 P45983-3 MAPK8 human T228 27724402 GGVLFPGtDHIDQWN Pkinase X -MAP2K4 MKK4 P45985 human JNK1 iso3 5599 P45983-3 MAPK8 human S377 454204 GVIRGQPsPLAQVQQ X -MAP2K4 MKK4 P45985 human JNK3 iso2 5602 P53779-2 MAPK10 human Y223 448035 TSFMMtPyVVTRYYR Pkinase X -MAP2K4 MKK4 P45985 human JNK2 26420 Q9WTU6 Mapk9 mouse Y185 447652 TNFMMtPyVVtRYYR Pkinase X -MAP2K4 MKK4 P45985 human JNK1 5599 P45983 MAPK8 human T183 447643 AGtsFMMtPyVVtRY Pkinase X 5136; 4668; 4671; 9257; 9255; 9251; 4306; 5755; 16014; 58328 -MAP2K4 MKK4 P45985 human JNK1 iso3 5599 P45983-3 MAPK8 human T183 447643 AGTSFMMtPyVVTRY Pkinase X -MAP2K4 MKK4 P45985 human P38A 1432 Q16539 MAPK14 human T180 447970 RHtDDEMtGyVAtRW Pkinase X X 9211; 9215; 4551; 9216; 4552; 4631; 4511; 4092; 9219; 24678; 8632; 6908; 41768; 51255; 14594; 14598; 62979 -MAP2K4 MKK4 P45985 human JNK1 iso3 5599 P45983-3 MAPK8 human S284 27724401 DVLFPADsEHNKLKA Pkinase X -MAP2K4 MKK4 P45985 human JNK1 iso3 5599 P45983-3 MAPK8 human Y185 447645 TSFMMtPyVVTRYYR Pkinase X -MAP2K4 MKK4 P45985 human MKK4 6416 P45985 MAP2K4 human T261 447656 LVDsIAKtRDAGCRP Pkinase X 9151; 9156 -MAP2K4 MKK4 P45985 human P38A 1432 Q16539 MAPK14 human Y182 447971 tDDEMtGyVAtRWYR Pkinase X X 9211; 9215; 4551; 9216; 4552; 4631; 4511; 4092; 9219; 24678; 8632; 6908; 41768; 51255; 14594; 14598; 62979 -DCAF1 VPRBP Q9Y4B6 human p53 7157 P04637 TP53 human S367 1881548604 GGsRAHssHLkskkG X X -DCAF1 VPRBP Q9Y4B6 human EZH2 14056 Q61188 Ezh2 mouse T367 466987 NNssRPstPtISVLE X X -DCAF1 VPRBP Q9Y4B6 human H2A.1 8329 P0C0S8 H2AC17 human T120 482914 AVLLPkktEsHHkAk Histone_H2A_C X -CLK4 CLK4 Q9HAZ1 human Abl 25 P00519 ABL1 human T735 450291 DTEWRSVtLPRDLQS X 2864 -CLK4 CLK4 Q9HAZ1 human MITF 4286 O75030 MITF human Y360 50783666 ILKAsVDyIRKLQRE HLH X -CLK4 CLK4 Q9HAZ1 human STF-1 2516 Q13285 NR5A1 human S203 447603 EYPEPYAsPPQPGLP X -PDPK1 PDK1 O15530 human SGK2 iso1 10110 Q9HBY8-1 SGK2 human T253 456159 EPEDTtStFCGtPEY Pkinase X -PDPK1 PDK1 O15530 human PDK1 5170 O15530 PDPK1 human S393 448581 MQVSSSSssHsLsAS X X -PDPK1 PDK1 O15530 human SGK1 29517 Q06226 Sgk1 rat T256 448431 EHNGTTstFCGTPEY Pkinase X -PDPK1 PDK1 O15530 human HIF2A 2034 Q99814 EPAS1 human T324 471073 VWLETQGtVIYNPRN PAS_3 X -PDPK1 PDK1 O15530 human PKCZ 5590 Q05513 PRKCZ human T410 447510 GPGDtTstFCGtPNy Pkinase X 9378; 2060 -PDPK1 PDK1 O15530 human p70S6K 6198 P23443 RPS6KB1 human T412 448607 NQVFLGFtyVAPsVL Pkinase_C X X 9206; 9234; 9205; 9209; 97596 -PDPK1 PDK1 O15530 human RSK2 110651 P18654 Rps6ka3 mouse T577 450152 AENGLLMtPCYtANF Pkinase X -PDPK1 PDK1 O15530 human Akt1 207 P31749 AKT1 human S473 447855 RPHFPQFsysAsGtA Pkinase_C X X 9271; 3787; 4060; 4051; 5102; 4058; 2336; 2337; 4075; 4070; 5012; 4071; 92982; 5315; 9563; 9018; 12694; 52240; 11962; 15116; 88106; 26580; 68035; 31957; 23430; 20235 -PDPK1 PDK1 O15530 human p90RSK 386579 P18652 RPS6KA1 chicken S381 447989 TSRTPKDsPGIPPSA Pkinase_C X X -PDPK1 PDK1 O15530 human PIP5K1C 23396 O60331 PIP5K1C human S448 17550224 NTVFRKNsSLKSsPS X X -PDPK1 PDK1 O15530 human p90RSK 6195 Q15418 RPS6KA1 human S221 447988 DHEKKAysFCGtVEy Pkinase X -PDPK1 PDK1 O15530 human PDK1 5170 O15530 PDPK1 human S410 448583 GLPQRSGsNIEQYIH X X -PDPK1 PDK1 O15530 human MEK1 5604 Q02750 MAP2K1 human S222 448513 LIDsMANsFVGtRSY Pkinase X X 2338; 9121; 3958; 9154; 16211; 86128; 16780; 75262 -PDPK1 PDK1 O15530 human p90RSK 81771 Q63531 Rps6ka1 rat S221 447988 DHEKKAYsFCGTVEY Pkinase X -PDPK1 PDK1 O15530 human Akt3 10000 Q9Y243 AKT3 human T305 448521 tDAAtMKtFCGtPEy Pkinase X 13842; 13038; 86758; 80722; 77440; 80556 -PDPK1 PDK1 O15530 human PDK1 5170 O15530 PDPK1 human S25 448580 VVLCsCPsPSMVRTQ X X -PDPK1 PDK1 O15530 human ASK1 26408 O35099 Map3k5 mouse S973 447736 NEYLRSIsLPVPVLV X 3764 -PDPK1 PDK1 O15530 human SGK1 6446 O00141 SGK1 human T256 448431 EHNSTTStFCGTPEY Pkinase X X -PDPK1 PDK1 O15530 human p70S6K iso2 6198 P23443-2 RPS6KB1 human T229 448606 HDGTVTHtFCGTIEY Pkinase X -PDPK1 PDK1 O15530 human PDK1 5170 O15530 PDPK1 human S396 448582 SSSSssHsLsASDTG X X -PDPK1 PDK1 O15530 human PKCD 170538 P09215 Prkcd rat T505 447511 FGENRAstFCGTPDy Pkinase X X 9379; 9374; 2060; 38938; 93292 -PDPK1 PDK1 O15530 human PGK1 5230 P00558 PGK1 human T243 2525475 IGGGMAFtFLKVLNN PGK X X -PDPK1 PDK1 O15530 human RSK2 110651 P18654 Rps6ka3 mouse S227 448063 DHEKKAysFCGtVEy Pkinase X X 3556 -PDPK1 PDK1 O15530 human PKN1 5585 Q16512 PKN1 human S773 4711320 MGyGDRtstFCGtPE Pkinase X -PDPK1 PDK1 O15530 human PKACA 18747 P05132 Prkaca mouse T198 448459 RVKGRtWtLCGtPEY Pkinase X 4781; 5661 -PDPK1 PDK1 O15530 human PDHA1 5160 P08559 PDHA1 human S293 448258 TYRyHGHsMsDPGVs E1_dh X 31866; 37115; 48447 -PDPK1 PDK1 O15530 human PDK1 5170 O15530 PDPK1 human S241 447693 skQARANsFVGtAQy Pkinase X X 3061; 3438 -PDPK1 PDK1 O15530 human ASK1 26408 O35099 Map3k5 mouse T845 448394 GINPCtEtFTGtLQY Pkinase X 3765 -PDPK1 PDK1 O15530 human Akt2 208 P31751 AKT2 human T309 448537 sDGAtMKtFCGtPEy Pkinase X 13842; 13038; 86758; 80722; 77440; 80556 -PDPK1 PDK1 O15530 human ITGB3 3690 P05106 ITGB3 human T779 470104 LyKEAtstFTNItyR Integrin_b_cyt X -PDPK1 PDK1 O15530 human p70S6K 6198 P23443 RPS6KB1 human S394 448806 TRQtPVDsPDDStLS Pkinase_C X 9208 -PDPK1 PDK1 O15530 human p70S6K 6198 P23443 RPS6KB1 human T252 448606 HDGtVtHtFCGtIEY Pkinase X X -PDPK1 PDK1 O15530 human PKACA 5566 P17612 PRKACA human T198 448459 RVKGRtWtLCGtPEy Pkinase X X 4781; 5661 -PDPK1 PDK1 O15530 human P70S6KB 58988 Q9Z1M4 Rps6kb2 mouse T228 1261114 HEGAItHtFCGTIEY Pkinase X -PDPK1 PDK1 O15530 human PKCZ 25522 P09217 Prkcz rat T410 447510 GPGDTTStFCGTPNY Pkinase X X 9378; 2060 -PDPK1 PDK1 O15530 human PDK1 5170 O15530 PDPK1 human T513 450132 PEAkNFKtFFVHTPN PH_3 X -PDPK1 PDK1 O15530 human SGK3 23678 Q96BR1 SGK3 human T320 448197 AIsDTtTtFCGtPEY Pkinase X X 5642 -PDPK1 PDK1 O15530 human MEK2 5605 P36507 MAP2K2 human S226 448074 LIDsMANsFVGtRSY Pkinase X X 2338; 9121; 3958; 9154; 16211; 86128; 16780; 75262 -PDPK1 PDK1 O15530 human RSK2 110651 P18654 Rps6ka3 mouse S386 448065 HQLFRGFsFVAITSD Pkinase_C X 9341; 9335; 13575; 11989; 12032; 75266; 93317; 13397; 13588 -PDPK1 PDK1 O15530 human PAK1 5058 Q13153 PAK1 human T423 448177 PEQSkRstMVGtPYW Pkinase X 2601 -PDPK1 PDK1 O15530 human PKCD 5580 Q05655 PRKCD human T507 447511 FGEsRAstFCGtPDy Pkinase X X 9379; 9374; 2060; 38938; 93292 -PDPK1 PDK1 O15530 human Akt1 11651 P31750 Akt1 mouse T308 447856 KDGAtMKtFCGtPEy Pkinase X X 5106; 2965; 9275; 4056; 5056; 13842; 13038; 43506; 48646; 86758; 80722; 77440; 80556 -PDPK1 PDK1 O15530 human TSSK3 58864 Q9D2E1 Tssk3 mouse T168 458324 SRRELsQtFCGSTAY Pkinase X -PDPK1 PDK1 O15530 human PDHA1 18597 P35486 Pdha1 mouse S232 448257 NRyGMGtsVERAAAS E1_dh X -PDPK1 PDK1 O15530 human ASK1 4217 Q99683 MAP3K5 human S966 447736 NEYLRsIsLPVPVLV X 3764 -PDPK1 PDK1 O15530 human PKN1 5585 Q16512 PKN1 human T774 447835 GyGDRtstFCGtPEF Pkinase X X 2611 -PDPK1 PDK1 O15530 human Akt1 207 P31749 AKT1 human T308 447856 kDGAtMKtFCGtPEy Pkinase X X 5106; 2965; 9275; 4056; 5056; 13842; 13038; 43506; 48646; 86758; 80722; 77440; 80556 -PDPK1 PDK1 O15530 human PKN2 5586 Q16513 PKN2 human T816 447838 GyGDRtstFCGtPEF Pkinase X 2611 -PDPK1 PDK1 O15530 human PKCB 5579 P05771 PRKCB human T500 447896 WDGVttktFCGtPDy Pkinase X 9379; 2060; 38938 -PDPK1 PDK1 O15530 human PKCE 5581 Q02156 PRKCE human T566 448787 LNGVTTTtFCGTPDy Pkinase X X 9379; 2060; 38938 -MAP3K5 ASK1 Q99683 human SIAH1 6477 Q8IUQ4 SIAH1 human T74 36694103 PKLtCCPtCRGPLGS X X -MAP3K5 ASK1 Q99683 human ASK1 4217 Q99683 MAP3K5 human T838 448394 GINPCTEtFTGtLQY Pkinase X 3765 -MAP3K5 ASK1 Q99683 human STRAP 11171 Q9Y3F4 STRAP human T175 11267002 LWDHAtMtEVKsLNF X -MAP3K5 ASK1 Q99683 human SIAH1 6477 Q8IUQ4 SIAH1 human T239 36694105 RRLtWEAtPRSIHEG Sina X X -MAP3K5 ASK1 Q99683 human SIAH1 6477 Q8IUQ4 SIAH1 human T70 36694104 SNCRPKLtCCPtCRG X X -MAP3K5 ASK1 Q99683 human JNK1 5599 P45983 MAPK8 human Y185 447645 tsFMMtPyVVtRYYR Pkinase X 5136; 4668; 4671; 9257; 9255; 9251; 4306; 5755; 16014; 58328 -MAP3K5 ASK1 Q99683 human ASK1 4217 Q99683 MAP3K5 human T842 450004 CTEtFTGtLQYMAPE Pkinase X -MAP3K5 ASK1 Q99683 human ZNF622 90441 Q969S3 ZNF622 human S314 20765001 WCNEkGksFYStEAV zf-C2H2_2 X X -MAP3K5 ASK1 Q99683 human EB1 22919 Q15691 MAPRE1 human S40 59049801 TKIEQLCsGAAYCQF CH X X -MAP3K5 ASK1 Q99683 human PDK1 5170 O15530 PDPK1 human S398 12729601 SSssHsLsASDTGLP X -MAP3K5 ASK1 Q99683 human p21Cip1 1026 P38936 CDKN1A human S98 478193 GGRRPGTsPALLQGT X X -MAP3K5 ASK1 Q99683 human SIAH1 6477 Q8IUQ4 SIAH1 human T235 36694106 NGHRRRLtWEAtPRS Sina X X -MAP3K5 ASK1 Q99683 human DAXX 1616 Q9UER7 DAXX human S176 3214944 TNAENTAsQsPRTRG X X -MAP3K5 ASK1 Q99683 human MKK3 5606 P46734 MAP2K3 human S218 448276 IsGyLVDsVAKtMDA Pkinase X 9231; 9236; 12280 -MAP3K5 ASK1 Q99683 human JNK1 5599 P45983 MAPK8 human T183 447643 AGtsFMMtPyVVtRY Pkinase X 5136; 4668; 4671; 9257; 9255; 9251; 4306; 5755; 16014; 58328 -MAP3K5 ASK1 Q99683 human MKK6 5608 P52564 MAP2K6 human S207 448194 IsGyLVDsVAKtIDA Pkinase X 9231; 12280 -MAP3K5 ASK1 Q99683 human P38A 1432 Q16539 MAPK14 human T180 447970 RHtDDEMtGyVAtRW Pkinase X 9211; 9215; 4551; 9216; 4552; 4631; 4511; 4092; 9219; 24678; 8632; 6908; 41768; 51255; 14594; 14598; 62979 -MAP3K5 ASK1 Q99683 human STRAP 11171 Q9Y3F4 STRAP human S179 11267003 AtMtEVKsLNFNMSV X -MAP3K5 ASK1 Q99683 human ZNF622 90441 Q969S3 ZNF622 human T318 20765000 kGksFYStEAVQAHM zf-C2H2_2 X X -MAP3K5 ASK1 Q99683 human DAXX 1616 Q9UER7 DAXX human S184 10438000 QsPRTRGsRRQIQRL X X -MAP3K5 ASK1 Q99683 human EB1 22919 Q15691 MAPRE1 human T206 59049802 QVNVLKLtVEDLEkE X X -MAP3K5 ASK1 Q99683 human EB1 22919 Q15691 MAPRE1 human T154 31883043 NkPkkPLtssSAAPQ X X -MAP3K5 ASK1 Q99683 human ASK1 4217 Q99683 MAP3K5 human T813 990312 GDNVLINtySGVLKI Pkinase X -MAP3K5 ASK1 Q99683 human MKK4 6416 P45985 MAP2K4 human T261 447656 LVDsIAKtRDAGCRP Pkinase X 9151; 9156 -MAP3K5 ASK1 Q99683 human PDK1 5170 O15530 PDPK1 human S394 12729600 QVSSSSssHsLsASD X -MAP3K5 ASK1 Q99683 human P38A 1432 Q16539 MAPK14 human Y182 447971 tDDEMtGyVAtRWYR Pkinase X 9211; 9215; 4551; 9216; 4552; 4631; 4511; 4092; 9219; 24678; 8632; 6908; 41768; 51255; 14594; 14598; 62979 -MAP3K5 ASK1 Q99683 human ASK1 4217 Q99683 MAP3K5 human S966 447736 NEYLRsIsLPVPVLV X 3764 -Srpk1 SRPK1 O70551 mouse PRM2 19119 P07978 Prm2 mouse S69 1868017300 RIHKRRRsCRRRRRH Protamine_P2 X -Srpk1 SRPK1 O70551 mouse PRM2 19119 P07978 Prm2 mouse S8 36700142 MVRYRMRsPsEGPHQ Protamine_P2 X -Srpk1 SRPK1 O70551 mouse PRM1 19118 P02319 Prm1 mouse S9 451410 ARYRCCRsKSRSRCR Protamine_P1 X X -Srpk1 SRPK1 O70551 mouse PRM1 19118 P02319 Prm1 mouse S43 36699681 RCCRRRRsYTIRCKK Protamine_P1 X X -Srpk1 SRPK1 O70551 mouse PRM2 19119 P07978 Prm2 mouse S10 36700145 RYRMRsPsEGPHQGP Protamine_P2 X -Srpk1 SRPK1 O70551 mouse PRM2 19119 P07978 Prm2 mouse S56 451411 HHRHRRCsRKRLHRI Protamine_P2 X -Cdk4 CDK4 P30285 mouse C/EBP-alpha 12606 P53566 Cebpa mouse S193 1868113505 PPPHPHAsPAHLAAP X X -Cdk4 CDK4 P30285 mouse Rb 19645 P13405 Rb1 mouse T819 447984 LPtPtKMtPRSRILV Rb_C X -Cdk4 CDK4 P30285 mouse Rb 19645 P13405 Rb1 mouse S804 448717 IyIsPLksPyKIsEG Rb_C X 9308; 8974; 4277; 40283; 8957; 8516; 11917; 41359; 75864 -Cdk4 CDK4 P30285 mouse IRS2 384783 P81122 Irs2 mouse S388 1984215 sVAGsPLsPGPVRAP X -Cdk4 CDK4 P30285 mouse ATOH1 11921 P48985 Atoh1 mouse S309 57761909 MMAQKDLsPsLPGGI X -Cdk4 CDK4 P30285 mouse UBF 21429 P25976 Ubtf mouse S484 450180 DRGKLPEsPKRAEEI HMG_box_5 X -Cdk4 CDK4 P30285 mouse SMAD3 4088 P84022 SMAD3 human T179 451177 PQSNIPEtPPPGYLS X -Cdk4 CDK4 P30285 mouse SMAD3 4088 P84022 SMAD3 human S213 451180 NLsPNPMsPAHNNLD X -Cdk4 CDK4 P30285 mouse Rb 19645 P13405 Rb1 mouse S243 447975 AAIPINGsPRtPRRG X -Cdk4 CDK4 P30285 mouse SMAD3 4088 P84022 SMAD3 human T8 452179 MSSILPFtPPIVkRL X -Cdk4 CDK4 P30285 mouse Rb 19645 P13405 Rb1 mouse T246 449821 PINGsPRtPRRGQNR X -Cdk4 CDK4 P30285 mouse Rb 19645 P13405 Rb1 mouse S800 447980 PGGNIyIsPLksPyK Rb_C X 9308; 8974; 4277; 40283; 8957; 8516; 11917; 41359; 75864; 72443 -EPHA8 EphA8 P29322 human GLO1 2739 Q04760 GLO1 human Y136 463450 GIAVPDVysACkRFE Glyoxalase X -Dclk1 DCAMKL1 Q9JLM8 mouse RPRC1 245877 A2AJI0 Map7d1 mouse S275 4688707 INKRLsksSAtLWNs X -Dclk1 DCAMKL1 Q9JLM8 mouse RPRC1 245877 A2AJI0 Map7d1 mouse S315 4170020 sFLARsRsAVtLPRN X -Dclk1 DCAMKL1 Q9JLM8 mouse RPRC1 245877 A2AJI0 Map7d1 mouse S308 41454179 RLMtPTLsFLARsRs X -Dclk1 DCAMKL1 Q9JLM8 mouse DCAMKL1 13175 Q9JLM8 Dclk1 mouse S382 450201 DELGRRHsLQRGWRR X -Eif2ak4 GCN2 Q9QZ05 mouse eIF2-alpha 13665 Q6ZWX6 Eif2s1 mouse S52 447635 MILLSELsRrrIRSI S1 X 3597; 9721; 3398; 5199; 53085; 95797 -MAP3K13 LZK O43283 human TRIM25 7706 Q14258 TRIM25 human S12 1868624700 CPLAEELsCSICLEP X X -PHKA1 PHKA1 P18688 rabbit PHKA1 100303771 P18688 PHKA1 rabbit S972 455914 KEFGVERsVRPTDSN X -PHKA1 PHKA1 P18688 rabbit PHKA1 100303771 P18688 PHKA1 rabbit S1007 455916 TGIMQLKsEIKQVEF X -PHKA1 PHKA1 P18688 rabbit PHKA1 100303771 P18688 PHKA1 rabbit S985 455915 SNVSPAIsIHEIGAV X -Csk CSK P32577 rat Src 396442 P00523 SRC chicken Y527 448235 FTSTEPQyQPGENL_ X 2105 -Csk CSK P32577 rat FGR 79113 Q6P6U0 Fgr rat Y511 448121 FTSTEPQyQPGDQT_ X -Csk CSK P32577 rat Src 83805 Q9WUD9 Src rat Y530 448235 FTSTEPQyQPGENL_ X 2105 -UL97 UL97 P16788 herpesvirus Rb 5925 P06400 RB1 human S780 447978 strPPtLsPIPHIPr Rb_C X 9307; 3590; 8180 -UL97 UL97 P16788 herpesvirus Rb 5925 P06400 RB1 human T356 447981 DsFEtQRtPRksNLD X 81403; 99158 -UL97 UL97 P16788 herpesvirus Rb 5925 P06400 RB1 human T826 447984 LPtPtkMtPRsRILV Rb_C X -UL97 UL97 P16788 herpesvirus Rb-like 2 5934 Q08999 RBL2 human S672 448254 tLyDRySsPPAsTtR X -UL97 UL97 P16788 herpesvirus Rb 5925 P06400 RB1 human S795 447979 sPykFPssPLrIPGG Rb_C X 9301 -UL97 UL97 P16788 herpesvirus Rb 5925 P06400 RB1 human S788 450022 PIPHIPrsPykFPss Rb_C X -UL97 UL97 P16788 herpesvirus Rb 5925 P06400 RB1 human S612 447977 MyLsPVRsPKKKGsT X -UL97 UL97 P16788 herpesvirus SAMHD1 25939 Q9Y3Z3 SAMHD1 human S278 468673 QIVGPLEsPVEDSLW HD X -UL97 UL97 P16788 herpesvirus Rb 5925 P06400 RB1 human T821 447983 kIsEGLPtPtkMtPR Rb_C X 31433 -UL97 UL97 P16788 herpesvirus Rb 5925 P06400 RB1 human T373 447982 VNVIPPHtPVRTVMN RB_A X -UL97 UL97 P16788 herpesvirus SAMHD1 25939 Q9Y3Z3 SAMHD1 human T592 468674 DVIAPLItPQkkEWN X X 89930; 87593; 55092; 45205 -UL97 UL97 P16788 herpesvirus Rb 5925 P06400 RB1 human S608 447976 tAADMyLsPVRsPKK X 2181; 8147 -UL97 UL97 P16788 herpesvirus Rb 5925 P06400 RB1 human S807 447980 PGGNIyIsPLksPyk Rb_C X 9308; 8974; 4277; 40283; 8957; 8516; 11917; 99274; 41359; 75864; 72443 -UL97 UL97 P16788 herpesvirus Rb 5925 P06400 RB1 human S811 448717 IyIsPLksPykIsEG Rb_C X 9308; 8974; 4277; 40283; 8957; 8516; 11917; 41359; 75864; 63276 -PRKACA PKACA Q8MJ44 dog Lasp-1 100009568 O77506 LASP1 rabbit S146 448836 AEPERRDsQDSSNYR X X -PRKACA PKACA Q8MJ44 dog PLB 414755 P61012 PLN dog S16 448114 RSAIRRAstIEMPQQ Phospholamban X 8496 -PRKACA PKACA Q8MJ44 dog PLB 414755 P61012 PLN dog T17 448115 SAIRRAstIEMPQQA Phospholamban X 8496 -PRKACA PKACA Q8MJ44 dog Lasp-1 100009568 O77506 LASP1 rabbit S99 450464 KNKGRGFsVVADTPE X X -CAMK1G CAMK1G Q96NX5 human EIF4G3 8672 O43432 EIF4G3 human S1156 2915400 NTFMRGGssKDLLDN X X -CKB CKB P12277 human P130Cas 9564 P56945 BCAR1 human Y327 448780 PLLREEtyDVPPAFA X X -KDR VEGFR2 P35968 human profilin 1 5216 P07737 PFN1 human Y129 450514 GLINkkCyEMAsHLR Profilin X -KDR VEGFR2 P35968 human VEGFR2 3791 P35968 KDR human Y1054 447899 FGLARDIykDPDyVR PK_Tyr_Ser-Thr X X -KDR VEGFR2 P35968 human VEGFR2 3791 P35968 KDR human Y1175 447901 AQQDGKDyIVLPISE X X 2478; 3770 -KDR VEGFR2 P35968 human VEGFR2 3791 P35968 KDR human Y1214 447902 VCDPKFHyDNtAGIS X X 2477 -KDR VEGFR2 P35968 human VEGFR2 3791 P35968 KDR human Y951 447903 RFRQGKDyVGAIPVD PK_Tyr_Ser-Thr X X 2476; 2471; 4991 -KDR VEGFR2 P35968 human VEGFR2 3791 P35968 KDR human Y996 447904 EEAPEDLyKDFLTLE PK_Tyr_Ser-Thr X X 2474 -KDR VEGFR2 P35968 human VEGFR2 3791 P35968 KDR human Y1059 447900 DIykDPDyVRKGDAR PK_Tyr_Ser-Thr X X -KDR VEGFR2 P35968 human profilin 1 513895 P02584 PFN1 cow Y129 450514 GMINKKCyEMASHLR Profilin X -GRK5 GRK5 P34947 human ADRB2 154 P07550 ADRB2 human S396 457440 GHQGtVPsDNIDsQG X -GRK5 GRK5 P34947 human Moesin 4478 P26038 MSN human T66 18911798 LkLNKkVtAQDVrkE FERM_N X X -GRK5 GRK5 P34947 human GRK5 2869 P34947 GRK5 human T485 451512 LDIEQFstVkGVNLD X -GRK5 GRK5 P34947 human GPBAR1 151306 Q8TDU6 GPBAR1 human S324 1877729206 YHPSsQssVDLDLN_ X -GRK5 GRK5 P34947 human HIP 6767 P50502 ST13 human S346 21006300 AQNPANMskYQsNPk STI1 X X -GRK5 GRK5 P34947 human GPBAR1 151306 Q8TDU6 GPBAR1 human S323 1877729204 AYHPSsQssVDLDLN X -GRK5 GRK5 P34947 human ADRB2 154 P07550 ADRB2 human S407 457443 DsQGRNCstNDsLL_ X -GRK5 GRK5 P34947 human FZD6 8323 O60353 FZD6 human S648 1275585104 sVSESARsEGRIsPK X -GRK5 GRK5 P34947 human GRK5 2869 P34947 GRK5 human T10 50780063 LENIVANtVLLkARE X -GRK5 GRK5 P34947 human SNCA 6622 P37840 SNCA human S129 448278 NEAyEMPsEEGyQDy Synuclein X X 23706; 87281 -GRK5 GRK5 P34947 human ADRB2 154 P07550 ADRB2 human S411 457444 RNCstNDsLL_____ X -GRK5 GRK5 P34947 human ADRB2 154 P07550 ADRB2 human S355 458916 KAyGNGyssNGNtGE X X -GRK5 GRK5 P34947 human ADRB2 154 P07550 ADRB2 human T393 457439 DFVGHQGtVPsDNID X -GRK5 GRK5 P34947 human GPBAR1 151306 Q8TDU6 GPBAR1 human S321 1877729202 SIAYHPSsQssVDLD X -GRK5 GRK5 P34947 human GPBAR1 151306 Q8TDU6 GPBAR1 human S310 1877729200 WGRASRDsPGPSIAY X -GRK5 GRK5 P34947 human MOR-1 18390 P42866 Oprm1 mouse S375 447784 QNtREHPstANtVDR X 3451 -GRK5 GRK5 P34947 human ADRB2 154 P07550 ADRB2 human S401 457441 VPsDNIDsQGRNCst X -GRK5 GRK5 P34947 human ADRB2 154 P07550 ADRB2 human S356 458917 AyGNGyssNGNtGEQ X X -GRK5 GRK5 P34947 human CMKOR1 12778 P56485 Ackr3 mouse T352 4709314 DAsRVsEtEysALEQ X -GRK5 GRK5 P34947 human CMKOR1 12778 P56485 Ackr3 mouse S350 4709309 LIDAsRVsEtEysAL X -GRK5 GRK5 P34947 human ADRB2 154 P07550 ADRB2 human T384 457437 LCEDLPGtEDFVGHQ X -GRK5 GRK5 P34947 human GRK5 2869 P34947 GRK5 human S484 451511 VLDIEQFstVkGVNL X -GRK5 GRK5 P34947 human HDAC6 10013 Q9UBN7 HDAC6 human S22 453006 RsRQNPQsPPQDSsV X X -GRK5 GRK5 P34947 human p53 7157 P04637 TP53 human T55 450685 DDIEQWFtEDPGPDE TAD2 X X -CSNK2A2 CK2A2 P19784 human CTNNB1 1499 P35222 CTNNB1 human T112 3075001 EGMQIPstQFdAAHP X -CSNK2A2 CK2A2 P19784 human SMC3 9126 Q9UQE7 SMC3 human S1067 453059 GDVEGsQsQDEGEGs SMC_N X -CSNK2A2 CK2A2 P19784 human CK2B 1460 P67870 CSNK2B human S3 447647 _____MsssEEVsWI X -CSNK2A2 CK2A2 P19784 human CCNH 902 P51946 CCNH human T315 455993 KHEEEEWtDDDLVEs X -CSNK2A2 CK2A2 P19784 human XRCC1 7515 P18887 XRCC1 human T523 451448 AGstDENtDsEEHQE X -CSNK2A2 CK2A2 P19784 human CDC37 11140 Q16543 CDC37 human S13 450034 VWDHIEVsDDEDETH CDC37_N X 13248 -CSNK2A2 CK2A2 P19784 human CTNNB1 1499 P35222 CTNNB1 human T102 3075002 RAAMFPEtLDEGMQI X -CSNK2A2 CK2A2 P19784 human p73 7161 O15350 TP73 human T27 2063601 SSLEPDStyFDLPQS X X -CSNK2A2 CK2A2 P19784 human TYMS 7298 P04818 TYMS human S124 13209303 FLDsLGFsTREEGDL Thymidylat_synt X -CSNK2A2 CK2A2 P19784 human CDC37 114562 Q63692 Cdc37 rat S13 450034 VWDHIEVsDDEDETH CDC37_N X 13248 -CSNK2A2 CK2A2 P19784 human NKX3-1 4824 Q99801 NKX3-1 human T93 464288 EAEtLAEtEPERHLG X X -CSNK2A2 CK2A2 P19784 human XRCC1 7515 P18887 XRCC1 human T488 451452 GAEDsGDtEDELRRV X -CSNK2A2 CK2A2 P19784 human SUZ12 23512 Q15022 SUZ12 human S583 4170593 PQEMEVDsEDEKDPE VEFS-Box X X -CSNK2A2 CK2A2 P19784 human SRPK1 6732 Q96SB4 SRPK1 human S555 456013 DYLFEPHsGEEYTRD Pkinase X -CSNK2A2 CK2A2 P19784 human XRCC1 7515 P18887 XRCC1 human S485 451510 QDNGAEDsGDtEDEL X -CSNK2A2 CK2A2 P19784 human SRPK1 6732 Q96SB4 SRPK1 human S51 456012 QEEEILGsDDDEQED X -CSNK2A2 CK2A2 P19784 human CTNNB1 1499 P35222 CTNNB1 human S29 3075000 VsHWQQQsyLDsGIH X -CSNK2A2 CK2A2 P19784 human XRCC1 7515 P18887 XRCC1 human S518 451449 GEDPyAGstDENtDs X -CSNK2A2 CK2A2 P19784 human XRCC1 7515 P18887 XRCC1 human T519 451450 EDPyAGstDENtDsE X -CSNK2A2 CK2A2 P19784 human FMR1 14265 P35922 Fmr1 mouse S499 469583 NSEAsNAsETESDHR FXMRP1_C_core X -CSNK2A2 CK2A2 P19784 human NKX3-1 4824 Q99801 NKX3-1 human T89 464287 AAPEEAEtLAEtEPE X X -CSNK2A2 CK2A2 P19784 human HSF1 3297 Q00613 HSF1 human T142 449066 DsVTKLLtDVQLMKG X X -CSNK2A2 CK2A2 P19784 human CK2B 1460 P67870 CSNK2B human S2 447646 ______MsssEEVsW X -ACVRL1 ALK1 P37023 human ENG 2022 P17813 ENG human S646 12064201 StNHSIGsTQstPCS X -ACVRL1 ALK1 P37023 human ENG 2022 P17813 ENG human T640 465627 AssESSStNHSIGsT X -ACVRL1 ALK1 P37023 human ENG 2022 P17813 ENG human T654 465628 TQstPCStSSMA___ X -ACVRL1 ALK1 P37023 human ENG 2022 P17813 ENG human S649 12064200 HSIGsTQstPCStSS X -Camkk1 CAMKK1 P97756 rat CAMK1A 171503 Q63450 Camk1 rat T177 448527 DPGSVLStACGTPGY Pkinase X -Camkk1 CAMKK1 P97756 rat AMPKA1 65248 P54645 Prkaa1 rat T183 448786 SDGEFLRtsCGSPNY Pkinase X 2535; 2531; 4188; 5256; 50081; 74281 -Camkk1 CAMKK1 P97756 rat CAMKK1 60341 P97756 Camkk1 rat S24 2864201 VERVAAIsVAHLEEA X -Camkk1 CAMKK1 P97756 rat CAMK4 25050 P13234 Camk4 rat T196 448164 EHQVLMktVCGtPGY Pkinase X -Camkk1 CAMKK1 P97756 rat CAMK4 25050 P13234 Camk4 rat T200 450234 LMktVCGtPGYCAPE Pkinase X -LRRK2 LRRK2 Q5S007 human Tau iso8 4137 P10636-8 MAPT human T231 449079 KKVAVVRtPPKsPss X 20473; 71429 -LRRK2 LRRK2 Q5S007 human LRRK2 120892 Q5S007 LRRK2 human T2031 10426322 CCRMGIKtsEGtPGF Pkinase X -LRRK2 LRRK2 Q5S007 human RAB10 10890 P61026 RAB10 human T73 471953 AGQERFHtITtsYYR Ras X X -LRRK2 LRRK2 Q5S007 human LRRK2 120892 Q5S007 LRRK2 human T424 13204421 ASANALStLLEQNVN X -LRRK2 LRRK2 Q5S007 human Radixin 5962 P35241 RDX human T564 448374 AGRDKyKtLRQIRQG ERM_C X 3141; 3726; 32600 -LRRK2 LRRK2 Q5S007 human LRRK2 120892 Q5S007 LRRK2 human T1967 11554400 QQDKASLtRtLQHRI Pkinase X -LRRK2 LRRK2 Q5S007 human DNAJC6 9829 O75061 DNAJC6 human S570 2518108 sATstSAsPtLRVGE X -LRRK2 LRRK2 Q5S007 human RAB12 19328 P35283 Rab12 mouse S105 487152 AGQERFNsITSAYYR Ras X -LRRK2 LRRK2 Q5S007 human LRRK2 120892 Q5S007 LRRK2 human Y1485 15785710 GFPAIRDyHFVNAtE X -LRRK2 LRRK2 Q5S007 human TUBB3 Q2T9S0 TUBB3 cow T107 4345618 NWAKGHYtEGAELVD Tubulin X -LRRK2 LRRK2 Q5S007 human LRRK2 120892 Q5S007 LRRK2 human Y1402 15785703 FAGREEFystHPHFM Roc X -LRRK2 LRRK2 Q5S007 human Ezrin 7430 P15311 EZR human T567 448104 QGRDkyKtLRQIRQG ERM_C X 3141; 3726; 32600 -LRRK2 LRRK2 Q5S007 human LRRK2 120892 Q5S007 LRRK2 human S1853 15785708 PRLtIPIsQIAPDLI X -LRRK2 LRRK2 Q5S007 human LRRK2 120892 Q5S007 LRRK2 human T1503 10426325 ALAKLRKtIINEsLN X X -LRRK2 LRRK2 Q5S007 human RAB5B 5869 P61020 RAB5B human T6 38546301 __MTSRStARPNGQP X X -LRRK2 LRRK2 Q5S007 human LRRK2 120892 Q5S007 LRRK2 human S955 4725908 RKRKILssDDsLRSs X -LRRK2 LRRK2 Q5S007 human LRRK2 120892 Q5S007 LRRK2 human S1292 13204416 PNEMGKLsKIWDLPL LRR_4 X X 65837 -LRRK2 LRRK2 Q5S007 human LRRK2 120892 Q5S007 LRRK2 human T1404 10426330 GREEFystHPHFMtQ Roc X -LRRK2 LRRK2 Q5S007 human ASK1 4217 Q99683 MAP3K5 human T838 448394 GINPCTEtFTGtLQY Pkinase X 3765 -LRRK2 LRRK2 Q5S007 human LRRK2 120892 Q5S007 LRRK2 human S973 4725913 SHMRHsDsIssLAsE X -LRRK2 LRRK2 Q5S007 human LRRK2 120892 Q5S007 LRRK2 human T838 13204423 KQtNIAstLARMVIR X -LRRK2 LRRK2 Q5S007 human RAB29 171122 Q63481 Rab29 rat S72 396518800 AGQERFTsMTRLYYR Ras X X -LRRK2 LRRK2 Q5S007 human Akt1 207 P31749 AKT1 human S473 447855 RPHFPQFsysAsGtA Pkinase_C X X 9271; 3787; 4060; 4051; 5102; 4058; 2336; 2337; 4075; 4070; 5012; 4071; 92982; 5315; 9563; 9018; 12694; 52240; 11962; 15116; 88106; 26580; 68035; 31957; 23430; 20235 -LRRK2 LRRK2 Q5S007 human LRRK2 120892 Q5S007 LRRK2 human S1457 15785720 VGtHLDVsDEKQRKA X -LRRK2 LRRK2 Q5S007 human LRRK2 120892 Q5S007 LRRK2 human T1491 10426326 DyHFVNAtEESDALA X -LRRK2 LRRK2 Q5S007 human LRRK2 120892 Q5S007 LRRK2 human S1443 15785705 FNIKARAsssPVILV Roc X -LRRK2 LRRK2 Q5S007 human Tau iso8 4137 P10636-8 MAPT human T263 487454 VKskIGstENLkHQP Tubulin-binding X -LRRK2 LRRK2 Q5S007 human NSF 4905 P46459 NSF human T645 53340201 RKLLIIGtTSRKDVL AAA X -LRRK2 LRRK2 Q5S007 human LRRK2 120892 Q5S007 LRRK2 human T1470 15785716 KACMsKItKELLNKR X -LRRK2 LRRK2 Q5S007 human DRP1 10059 O00429 DNM1L human T595 28716001 NWRGMLktSkAEELL X X -LRRK2 LRRK2 Q5S007 human LRRK2 120892 Q5S007 LRRK2 human T1343 10426319 KLMIVGNtGsGKttL Roc X -LRRK2 LRRK2 Q5S007 human LRRK2 120892 Q5S007 LRRK2 human T1969 11554401 DKASLtRtLQHRIAL Pkinase X -LRRK2 LRRK2 Q5S007 human LRRK2 120892 Q5S007 LRRK2 human S1253 15785719 RVEKLHLsHNKLKEI LRR_4 X -LRRK2 LRRK2 Q5S007 human HDAC3 8841 O15379 HDAC3 human S424 455624 DHDNDKEsDVEI___ X 3815 -LRRK2 LRRK2 Q5S007 human LRRK2 120892 Q5S007 LRRK2 human S1345 10426331 MIVGNtGsGKttLLQ Roc X -LRRK2 LRRK2 Q5S007 human LRRK2 120892 Q5S007 LRRK2 human S935 4725898 NLQRHsNsLGPIFDH X X 59576 -LRRK2 LRRK2 Q5S007 human Tau iso8 4137 P10636-8 MAPT human T153 449076 DGKtKIAtPRGAAPP X X -LRRK2 LRRK2 Q5S007 human APP 351 P05067 APP human T743 448523 VEVDAAVtPEERHLS APP_amyloid X X 3823; 6986 -LRRK2 LRRK2 Q5S007 human Tau iso8 4137 P10636-8 MAPT human T149 487446 AKGADGKtKIAtPRG X X -LRRK2 LRRK2 Q5S007 human TUBB2B Q6B856 TUBB2B cow T107 4611909 NWAKGHYtEGAELVD Tubulin X -LRRK2 LRRK2 Q5S007 human LRRK2 120892 Q5S007 LRRK2 human S2032 3306338 CRMGIKtsEGtPGFR Pkinase X -LRRK2 LRRK2 Q5S007 human AP2M1 1173 Q96CW1 AP2M1 human T156 448782 SQItsQVtGQIGWRR X X 3843; 7399 -LRRK2 LRRK2 Q5S007 human ASK1 4217 Q99683 MAP3K5 human T825 34366326 LKIsDFGtSkRLAGI Pkinase X X -LRRK2 LRRK2 Q5S007 human SQSTM1 8878 Q13501 SQSTM1 human T138 900975704 CNGPVVGtRYkCsVC ZZ X X -LRRK2 LRRK2 Q5S007 human LRRK2 120892 Q5S007 LRRK2 human S1913 15785702 KIFNKHtsLRLLRQE Pkinase X -LRRK2 LRRK2 Q5S007 human LRRK2 120892 Q5S007 LRRK2 human S1444 15785707 NIKARAsssPVILVG Roc X -LRRK2 LRRK2 Q5S007 human RPS11 6205 P62280 RPS11 human T28 27460386 kRVLLGEtGkEkLPR Ribosomal_S17_N X -LRRK2 LRRK2 Q5S007 human RAB8A 4218 P61006 RAB8A human T72 4709152 AGQERFRtITTAyyR Ras X X -LRRK2 LRRK2 Q5S007 human LRRK2 120892 Q5S007 LRRK2 human T2524 15785717 LAEKMRRtSVE____ X -LRRK2 LRRK2 Q5S007 human LRRK2 120892 Q5S007 LRRK2 human T776 13204419 QDVRKALtISIGKGD X -LRRK2 LRRK2 Q5S007 human LRRK2 120892 Q5S007 LRRK2 human T1452 10426327 sPVILVGtHLDVsDE Roc X -LRRK2 LRRK2 Q5S007 human LRRK2 120892 Q5S007 LRRK2 human S1283 15785712 SYNLELRsFPNEMGK LRR_4 X -LRRK2 LRRK2 Q5S007 human LRRK2 120892 Q5S007 LRRK2 human T1368 13204422 DLGMQSAtVGIDVKD Roc X -LRRK2 LRRK2 Q5S007 human LRRK2 120892 Q5S007 LRRK2 human T1410 10426324 stHPHFMtQRALYLA Roc X X -LRRK2 LRRK2 Q5S007 human LRRK2 120892 Q5S007 LRRK2 human T1612 15785700 KIMAQILtVKVEGCP COR X -LRRK2 LRRK2 Q5S007 human LRRK2 120892 Q5S007 LRRK2 human S1403 10426321 AGREEFystHPHFMt Roc X -LRRK2 LRRK2 Q5S007 human LRRK2 120892 Q5S007 LRRK2 human S910 4725893 LVKKKsNsIsVGEFY X -LRRK2 LRRK2 Q5S007 human LRRK2 120892 Q5S007 LRRK2 human S1467 15785704 KQRKACMsKItKELL X -LRRK2 LRRK2 Q5S007 human RAB10 19325 P61027 Rab10 mouse T73 471953 AGQERFHtITTSYYR Ras X -LRRK2 LRRK2 Q5S007 human LRRK2 120892 Q5S007 LRRK2 human T1849 15785709 NPDQPRLtIPIsQIA X -LRRK2 LRRK2 Q5S007 human p53 7157 P04637 TP53 human T377 3309800 kskkGQstsRHkkLM X X -LRRK2 LRRK2 Q5S007 human LRRK2 120892 Q5S007 LRRK2 human T1357 15785718 LLQQLMKtKKSDLGM Roc X -LRRK2 LRRK2 Q5S007 human LARS 51520 Q9P2J5 LARS1 human T293 1345849602 NIFLVAAtLRPETMF tRNA-synt_1 X X -LRRK2 LRRK2 Q5S007 human RPS11 6205 P62280 RPS11 human T46 33515800 NIGLGFktPkEAIEG Ribosomal_S17_N X -LRRK2 LRRK2 Q5S007 human LRRK2 120892 Q5S007 LRRK2 human S2257 15785715 CNSFSKQsKQKNFLL X -LRRK2 LRRK2 Q5S007 human LRRK2 120892 Q5S007 LRRK2 human T524 13204424 PEESREDtEFHHKLN X -LRRK2 LRRK2 Q5S007 human LRRK2 120892 Q5S007 LRRK2 human T2483 13204417 NRKNTEGtQKQKEIQ X -LRRK2 LRRK2 Q5S007 human WAVE2 242687 Q8BH43 Wasf2 mouse T96 1107491500 VSLQGINtRKAFRSS X X -LRRK2 LRRK2 Q5S007 human p53 7157 P04637 TP53 human T304 50310600 HELPPGStkRALPNN X X -LRRK2 LRRK2 Q5S007 human LRRK2 120892 Q5S007 LRRK2 human T1912 15785713 VKIFNKHtsLRLLRQ Pkinase X -LRRK2 LRRK2 Q5S007 human Tau iso8 4137 P10636-8 MAPT human T169 487447 QkGQANAtRIPAktP X -LRRK2 LRRK2 Q5S007 human FZD3 7976 Q9NPG1 FZD3 human T598 1869636102 RSRDGRYtPCSYRGM X -LRRK2 LRRK2 Q5S007 human TUBB2C Q3MHM5 TUBB2C cow T107 4611914 NWAKGHYtEGAELVD Tubulin X -LRRK2 LRRK2 Q5S007 human LRRK2 120892 Q5S007 LRRK2 human T1348 10426320 GNtGsGKttLLQQLM Roc X -LRRK2 LRRK2 Q5S007 human LRRK2 120892 Q5S007 LRRK2 human S1124 13204425 NkISGICsPLRLkEL X -LRRK2 LRRK2 Q5S007 human SYN1 24949 P09951 Syn1 rat T339 2020533 sGNWKtNtGsAMLEQ Synapsin_C X -LRRK2 LRRK2 Q5S007 human Tau iso8 4137 P10636-8 MAPT human T181 447932 ktPPAPktPPssGEP X 12885; 66224; 62672 -LRRK2 LRRK2 Q5S007 human RPS15 6209 P62841 RPS15 human T136 18913279 GRPGIGAtHssRFIP X X -LRRK2 LRRK2 Q5S007 human LRRK2 120892 Q5S007 LRRK2 human T833 13204418 tSNLRKQtNIAstLA X -LRRK2 LRRK2 Q5S007 human LRRK2 120892 Q5S007 LRRK2 human S5 13204415 ___MAsGsCQGCEED X -LRRK2 LRRK2 Q5S007 human RAB29 226422 Q91YQ1 Rab29 mouse T71 406855300 IAGQERFtSMTRLYY Ras X -LRRK2 LRRK2 Q5S007 human LRRK2 120892 Q5S007 LRRK2 human Y1332 10370351 RLKKAVPyNRMKLMI X -LRRK2 LRRK2 Q5S007 human LRRK2 120892 Q5S007 LRRK2 human T2035 477192 GIKtsEGtPGFRAPE Pkinase X -LRRK2 LRRK2 Q5S007 human Moesin 4478 P26038 MSN human T558 447706 LGRDKyKtLRQIRQG ERM_C X 3141; 3726; 32600 -LRRK2 LRRK2 Q5S007 human LRRK2 120892 Q5S007 LRRK2 human S1445 15785711 IKARAsssPVILVGt Roc X -LRRK2 LRRK2 Q5S007 human RAB8A 17274 P55258 Rab8a mouse T72 4709152 AGQERFRtITTAYYR Ras X -LRRK2 LRRK2 Q5S007 human TUBB4 Q3ZBU7 TUBB4 cow T107 9467901 NWAKGHYtEGAELVD Tubulin X -LRRK2 LRRK2 Q5S007 human Tau iso8 4137 P10636-8 MAPT human T212 447934 tPGsRsRtPsLPtPP X -LRRK2 LRRK2 Q5S007 human LRRK2 120892 Q5S007 LRRK2 human S1647 15785714 KFPKNYMsQYFKLLE COR X -LRRK2 LRRK2 Q5S007 human LRRK2 120892 Q5S007 LRRK2 human S1508 15785706 RKtIINEsLNFKIRD X -LRRK2 LRRK2 Q5S007 human LRRK2 120892 Q5S007 LRRK2 human T826 13204420 GPLFPDKtSNLRKQt X -LRRK2 LRRK2 Q5S007 human SYN1 24949 P09951 Syn1 rat T337 486180 SVsGNWKtNtGsAML Synapsin_C X -LRRK2 LRRK2 Q5S007 human LRRK2 66725 Q5S006 Lrrk2 mouse S1292 13204416 PNEMGKLsKIWDLPL LRR_4 X X 65837 -LRRK2 LRRK2 Q5S007 human TUBB Q2KJD0 TUBB5 cow T107 4345619 NWAKGHYtEGAELVD Tubulin X -LRRK2 LRRK2 Q5S007 human WAVE2 242687 Q8BH43 Wasf2 mouse T470 56675609 VVGNDVAtILsRRIA X X -LRRK2 LRRK2 Q5S007 human SNAPIN 23557 O95295 SNAPIN human T117 28761202 NHsVAKEtARRRAML X X -LRRK2 LRRK2 Q5S007 human Tau iso8 4137 P10636-8 MAPT human T205 447933 ssPGsPGtPGsRsRt X 25377; 43964; 53001; 49561; 20060; 33032; 30505; 20739; 98160 -LRRK2 LRRK2 Q5S007 human LRRK2 120892 Q5S007 LRRK2 human S1536 15785701 ELEKIILsERKNVPI COR X -LRRK2 LRRK2 Q5S007 human RPS11 6205 P62280 RPS11 human T54 15414577 PkEAIEGtyIDkkCP Ribosomal_S17_N X -LRRK2 LRRK2 Q5S007 human LRRK2 120892 Q5S007 LRRK2 human S3 13204414 _____MAsGsCQGCE X -SIK1 SIK P57059 human PANX1 55991 Q9JIP4 Panx1 mouse S205 1874115103 yLKTKKNsSHLIMKY Innexin X -SIK1 SIK P57059 human HDAC5 10014 Q9UQL6 HDAC5 human S661 7237900 QALGRTQsSPAAPGG X X -SIK1 SIK P57059 human TORC3 70461 Q91X84 Crtc3 mouse S162 7101661 SALNRTNsDSALHTS TORC_M X -SIK1 SIK P57059 human TORC3 70461 Q91X84 Crtc3 mouse S370 1210886 SLRLFsLsNPsLSTT X -SIK1 SIK P57059 human TPI1 7167 P60174 TPI1 human S21 465652 kMNGRkQsLGELIGt TIM X -SIK1 SIK P57059 human SCARB1 25073 P97943 Scarb1 rat S496 14567809 AYSESLMsPAAkGTV X -SIK1 SIK P57059 human TORC3 70461 Q91X84 Crtc3 mouse S62 3203139 LtQyHGGsLPNVSQL TORC_N X -SIK1 SIK P57059 human SREBP-1 iso4 20787 Q9WTN3-4 Srebf1 mouse S329 7996201 KSLKDLVsACGSGGG X -SIK1 SIK P57059 human TORC2 74343 Q3U182 Crtc2 mouse S171 454622 sALNRtSsDsALHTs TORC_M X -SIK1 SIK P57059 human TORC3 70461 Q91X84 Crtc3 mouse S329 468980 SGLQSsRsNPsIQAT X -SIK1 SIK P57059 human SMRT 9612 Q9Y618 NCOR2 human T1383 3217644 KLLKREGtPPPPPPs X X -SIK1 SIK P57059 human TORC2 74343 Q3U182 Crtc2 mouse S275 3174300 PAMNTGGsLPDLTNL TORC_M X X -SIK1 SIK P57059 human TORC2 74343 Q3U182 Crtc2 mouse S307 454633 PSLSGGNsTTNLTHT TORC_M X X -Ikbke IKKE Q9R0T8 mouse IkB-alpha 18035 Q9Z1E3 Nfkbia mouse S32 448203 LVDDRHDsGLDsMKD X 5210; 2859; 9246; 5209 -Ikbke IKKE Q9R0T8 mouse IKKE 56489 Q9R0T8 Ikbke mouse S172 447631 DDDEKFVsVYGTEEY Pkinase X 8766 -Ikbke IKKE Q9R0T8 mouse IkB-alpha 18035 Q9Z1E3 Nfkbia mouse S36 448204 RHDsGLDsMKDEEYE X 5210; 9246 -Ikbke IKKE Q9R0T8 mouse Snail1 20613 Q02085 Snai1 mouse S165 1876128600 YCNKEYLsLGALKMH zf-C2H2_6 X -Ikbke IKKE Q9R0T8 mouse TRAF3IP2 103213 Q8N7N6 Traf3ip2 mouse S311 21041604 KVILNDSsPQDQEER X -MAPK14 P38A Q16539 human ULK1 22241 O70405 Ulk1 mouse S757 483139 PVVFtVGsPPsGAtP X 14202; 6888; 29313 -MAPK14 P38A Q16539 human Tau iso8 4137 P10636-8 MAPT human T231 449079 KKVAVVRtPPKsPss X 20473; 71429 -MAPK14 P38A Q16539 human JTV1 7965 Q13155 AIMP2 human S156 55571504 LSTVHtHssVkSVPE Thioredoxin_16 X -MAPK14 P38A Q16539 human NHE1 6548 P19634 SLC9A1 human S726 2509107 IDPAsPQsPEsVDLV X X -MAPK14 P38A Q16539 human ATG5 11793 Q99J83 Atg5 mouse T75 27138202 IWFEYEGtPLKWHYP X -MAPK14 P38A Q16539 human MEF2D 4209 Q14814 MEF2D human S180 449933 LTDPRLLsPQQPALQ X -MAPK14 P38A Q16539 human SRC-2 17978 Q61026 Ncoa2 mouse S736 465446 tVKQEPAsPKKKENA DUF4927 X X -MAPK14 P38A Q16539 human MKL1 223701 Q8K4J6 Mrtfa mouse S492 467355 TGstPPVsPTPsERS X -MAPK14 P38A Q16539 human ATF-2 1386 P15336 ATF2 human T69 448224 sVIVADQtPtPtRFL X X 9225; 94125; 40749; 61584; 44167 -MAPK14 P38A Q16539 human STAT1 6772 P42224 STAT1 human S727 447753 TDNLLPMsPEEFDEV STAT1_TAZ2bind X 9177; 8826; 62390 -MAPK14 P38A Q16539 human Tau iso8 4137 P10636-8 MAPT human S199 447927 GDRsGyssPGsPGtP X X 29957 -MAPK14 P38A Q16539 human DDIT3 1649 P35638 DDIT3 human S79 448090 EVTSTSQsPHsPDSS X -MAPK14 P38A Q16539 human p47phox 653361 P14598 NCF1 human S348 451728 PGPQsPGsPLEEERQ X -MAPK14 P38A Q16539 human SLC6A2 6530 P23975 SLC6A2 human T30 4957152 QPLRARKtAELLVVK X -MAPK14 P38A Q16539 human NPHS1 54631 Q9QZS7 Nphs1 mouse S1160 1876873800 YYSMRDFsPQLPPTL X X -MAPK14 P38A Q16539 human ATF-2 1386 P15336 ATF2 human T71 448225 IVADQtPtPtRFLkN X X 9225; 9221; 5112; 94125; 13850; 40749; 15411; 24329; 61584; 27934; 92109; 20534; 35858 -MAPK14 P38A Q16539 human 4E-BP1 13685 Q60876 Eif4ebp1 mouse S64 447527 FLMECRNsPVAKtPP eIF_4EBP X 9451; 9456 -MAPK14 P38A Q16539 human JDP2 122953 Q8WYK2 JDP2 human T148 448312 VRtDsVKtPEsEGNP X -MAPK14 P38A Q16539 human TACE 6868 P78536 ADAM17 human T735 449804 kPFPAPQtPGRLQPA X X -MAPK14 P38A Q16539 human SIAH2 20439 Q06986 Siah2 mouse S29 471339 PQtPHAPsPAAPPAA X -MAPK14 P38A Q16539 human ELK4 2005 P28324 ELK4 human S387 4317601 LsPVAPLsPARLQGA X X -MAPK14 P38A Q16539 human p63 iso2 8626 Q9H3D4-2 TP63 human S361 451603 QKQtsIQsPSSYGNs X X -MAPK14 P38A Q16539 human SHC1 6464 P29353 SHC1 human S54 457345 PPLPGDDsPTTLCSF X -MAPK14 P38A Q16539 human NOXA1 10811 Q86UR1 NOXA1 human S239 12570901 ARsLIMDsPRAGTHQ X -MAPK14 P38A Q16539 human Tel 2120 P41212 ETV6 human S257 451378 ESHPKPSsPRQESTR X -MAPK14 P38A Q16539 human RBM17 84991 Q96I25 RBM17 human S222 3209223 EEQDRPRsPtGPsNs X -MAPK14 P38A Q16539 human ELK1 2002 P19419 ELK1 human S389 449757 LsPIAPRsPAKLSFQ X -MAPK14 P38A Q16539 human FPR1 2357 P21462 FPR1 human S342 450850 AtNstLPsAEVELQA X X -MAPK14 P38A Q16539 human PGC-1 alpha 10891 Q9UBK2 PPARGC1A human T263 448241 TTLSLPLtPEsPNDP X X -MAPK14 P38A Q16539 human smMLCK 4638 Q15746 MYLK human T978 15423395 VPPPKPAtPDFRSVL X -MAPK14 P38A Q16539 human C/EBP-alpha 24252 P05554 Cebpa rat S21 448308 PMSSHLQsPPHAPSN X 2841 -MAPK14 P38A Q16539 human Kv7.2 iso4 3785 O43526-4 KCNQ2 human S436 481665 QAQTVRRsPsADQSL KCNQ_channel X -MAPK14 P38A Q16539 human SHC1 6464 P29353 SHC1 human T386 457351 PTAPNAQtPSHLGAT X -MAPK14 P38A Q16539 human FOXC1 2296 Q12948 FOXC1 human S241 3195017 PsPPQPLsPAAALGS X -MAPK14 P38A Q16539 human MEF2D 4209 Q14814 MEF2D human S98 470518 KGFNGCDsPEPDGED HJURP_C X -MAPK14 P38A Q16539 human MZF-1 109889 O70162 Mzf1 mouse S336 448731 EEVGGIFsPGFTLQM X -MAPK14 P38A Q16539 human P38A 26416 P47811 Mapk14 mouse T180 447970 RHtDDEMtGyVAtRW Pkinase X 9211; 9215; 4551; 9216; 4552; 4631; 4511; 4092; 9219; 24678; 8632; 6908; 41768; 51255; 14594; 14598; 62979 -MAPK14 P38A Q16539 human 4E-BP1 13685 Q60876 Eif4ebp1 mouse T45 447496 GGtLFsttPGGtRII eIF_4EBP X 2855; 9459; 2846; 4923; 5123; 3929; 7547; 45613; 39788 -MAPK14 P38A Q16539 human PGC-1 alpha 10891 Q9UBK2 PPARGC1A human T299 448009 AGLtPPTtPPHKANQ X X -MAPK14 P38A Q16539 human PDX1 3651 P52945 PDX1 human S66 458402 QGsPPDIsPYEVPPL X -MAPK14 P38A Q16539 human DLX5 13395 P70396 Dlx5 mouse S217 1725301 SDPMACNsPQSPAVW X X -MAPK14 P38A Q16539 human PKR 5610 P19525 EIF2AK2 human T451 448089 kRtRSKGtLRyMsPE Pkinase X -MAPK14 P38A Q16539 human p63 8626 Q9H3D4 TP63 human S160 451600 SSTFDALsPsPAIPS X 4981 -MAPK14 P38A Q16539 human eNOS 4846 P29474 NOS3 human S600 34729904 MSGPYNSsPRPEQHK Flavodoxin_1 X X -MAPK14 P38A Q16539 human MAP4 4134 P27816 MAP4 human S696 449564 PNKELPPsPEKKTkP X -MAPK14 P38A Q16539 human CASP8 841 Q14790 CASP8 human S347 450983 FTGLkCPsLAGkPkV Peptidase_C14 X X -MAPK14 P38A Q16539 human CDT1 81620 Q9H211 CDT1 human S391 20804632 LRSAAPssPGsPrPA X X -MAPK14 P38A Q16539 human DDX5 1655 P17844 DDX5 human T446 15409321 GtAyTFFtPNNIkQV X -MAPK14 P38A Q16539 human USP21 27005 Q9UK80 USP21 human S538 63253102 VYNDSRVsPVSENQV UCH X X -MAPK14 P38A Q16539 human Mnk1 iso2 8569 Q9BUB5-2 MKNK1 human T214 447622 ITtPELTtPCGSAEY Pkinase X 2111; 43507 -MAPK14 P38A Q16539 human p53 7157 P04637 TP53 human S46 447536 AMDDLMLsPDDIEQW TAD2 X X 2521 -MAPK14 P38A Q16539 human Kv2.1 3745 Q14721 KCNB1 human S805 473562 ESsPLPtsPKFLRQN X -MAPK14 P38A Q16539 human WSTF 9031 Q9UIG0 BAZ1B human S158 3215310 ksDGACDsPssDKEN X -MAPK14 P38A Q16539 human Mnk1 8569 Q9BUB5 MKNK1 human T250 447621 NSCTPITtPELTtPC Pkinase X 2111; 43507 -MAPK14 P38A Q16539 human MEF2A 4205 Q02078 MEF2A human T319 448098 tPVVSVTtPSLPPQG X -MAPK14 P38A Q16539 human HuR 1994 Q15717 ELAVL1 human T118 474554 sGLPRTMtQkDVEDM RRM_1 X X -MAPK14 P38A Q16539 human Tau iso8 4137 P10636-8 MAPT human S396 449081 GAEIVyKsPVVsGDt X X 9632 -MAPK14 P38A Q16539 human SERT 6532 P31645 SLC6A4 human T616 7576402 IKsItPEtPTEIPCG X -MAPK14 P38A Q16539 human RCAN1 54720 Q9JHG6 Rcan1 mouse T177 8142805 WKQVEDAtPVINYDL Calcipressin X -MAPK14 P38A Q16539 human Tau iso8 4137 P10636-8 MAPT human S404 449082 PVVsGDtsPRHLsNV X X 35834; 20194; 98523; 91600; 49562 -MAPK14 P38A Q16539 human TAB1 10454 Q15750 TAB1 human T431 456223 ASTLDEAtPTLTNQs X X -MAPK14 P38A Q16539 human MAPKAPK2 9261 P49137 MAPKAPK2 human S272 448268 SNHGLAIsPGMKTRI Pkinase X X -MAPK14 P38A Q16539 human Oct7 5454 P20265 POU3F2 human S96 1868139201 DGsPWSTsPLGQPDI X -MAPK14 P38A Q16539 human S100A9 6280 P06702 S100A9 human T113 455888 KPGLGEGtP______ X -MAPK14 P38A Q16539 human MAFA 389692 Q8NHW3 MAFA human T57 456028 LSStPLStPCSsVPS X -MAPK14 P38A Q16539 human CDT1 81620 Q9H211 CDT1 human T402 20804634 PrPALPAtPPAtPPA X X -MAPK14 P38A Q16539 human RCAN1 54720 Q9JHG6 Rcan1 mouse T206 21511700 LHAATDTtPSVVVHV Calcipressin X -MAPK14 P38A Q16539 human NFAT3 4776 Q14934 NFATC4 human S168 448859 QGGGAFFsPsPGsSS X -MAPK14 P38A Q16539 human HePTP 5778 P35236 PTPN7 human S93 448310 ALQRQPPsPKQLEEE X -MAPK14 P38A Q16539 human H3 360198 P68433 H3c1 mouse S10 455676 tkQTARkstGGkAPr Histone X 9701; 9711; 9606; 3465; 3642; 3377; 3475; 3458; 5764; 47398; 8481; 8552; 53348; 29237; 66065; 43185; 64522; 52725 -MAPK14 P38A Q16539 human FOXO3A 2309 O43524 FOXO3 human S7 9318032 _MAEAPAsPAPLsPL X X 14724 -MAPK14 P38A Q16539 human Kv2.1 25736 P15387 Kcnb1 rat S799 473567 EKNHFESsPLPTsPK X -MAPK14 P38A Q16539 human EPS15 2060 P42566 EPS15 human S796 1983704 RsINkLDsPDPFkLN X X -MAPK14 P38A Q16539 human SRC-3 8202 Q9Y6Q9 NCOA3 human S860 454106 NRAVsLDsPVsVGss X X -MAPK14 P38A Q16539 human HBP1 26959 O60381 HBP1 human S402 455671 GFSkNCGsPGSSQLS X X -MAPK14 P38A Q16539 human Rb 5925 P06400 RB1 human T841 14160965 sIGEsFGtsEkFQkI Rb_C X X -MAPK14 P38A Q16539 human RPS27 6232 P42677 RPS27 human S27 4272667 KKkRLVQsPNsyFMD X -MAPK14 P38A Q16539 human TAB1 10454 Q15750 TAB1 human S452 22869801 STNTHTQssSSssDG X X -MAPK14 P38A Q16539 human FOXO3A 2309 O43524 FOXO3 human S294 472326 QLskWPGsPtsRsSD X 5538 -MAPK14 P38A Q16539 human KARS 3735 Q15046 KARS1 human S49 23117372 ELsEKQLsQAtAAAT X -MAPK14 P38A Q16539 human MEF2D 4209 Q14814 MEF2D human S251 3196577 NkVIPAksPPPPtHS X -MAPK14 P38A Q16539 human HTRA2 27429 O43464 HTRA2 human S142 487466 VPSPPPAsPRSQYNF Peptidase_M50 X -MAPK14 P38A Q16539 human MITF iso8 17342 Q08874-8 Mitf mouse S307 451221 IPSTGLCsPDLVNRI DUF3371 X -MAPK14 P38A Q16539 human MAP4 17758 P27546 Map4 mouse S737 476119 ATATARPsTLPARDV X -MAPK14 P38A Q16539 human K8 3856 P05787 KRT8 human S74 448539 tVNQsLLsPLVLEVD Keratin_2_head X X -MAPK14 P38A Q16539 human E2F4 E1BUH4 E2F4 chicken T263 25571900 STQPStPtPSSTQDH X -MAPK14 P38A Q16539 human ISL1 3670 P61371 ISL1 human S269 515814094 GTPMVAAsPERHDGG X X -MAPK14 P38A Q16539 human FGFR1 2260 P11362 FGFR1 human S777 2721300 SMPLDQysPsFPDTR X X -MAPK14 P38A Q16539 human p63 iso2 8626 Q9H3D4-2 TP63 human S68 451601 TFDALsPsPAIPSNT X X -MAPK14 P38A Q16539 human GSK3B 2932 P49841 GSK3B human T43 456221 kVTTVVAtPGQGPDR X -MAPK14 P38A Q16539 human fumarase 2271 P07954 FH human T90 3823351 GVtERMPtPVIkAFG Lyase_1 X -MAPK14 P38A Q16539 human EGFR 1956 P00533 EGFR human T1041 3178896 LLSsLsAtsNNstVA X -MAPK14 P38A Q16539 human CDX2 1045 Q99626 CDX2 human S283 456208 RsVPEPLsPVSSLQA X -MAPK14 P38A Q16539 human smMLCK 4638 Q15746 MYLK human S947 4739853 EEERKVHsPQQVDFR X -MAPK14 P38A Q16539 human SCN10A Q62968 Scn10a rat S556 2482301 PRsPLPQsPNPGRRH X X -MAPK14 P38A Q16539 human Oct7 5454 P20265 POU3F2 human T440 4928201 PPHHGVQtPVQ____ X -MAPK14 P38A Q16539 human TAB1 10454 Q15750 TAB1 human S456 22869802 HTQssSSssDGGLFR X X -MAPK14 P38A Q16539 human NFAT3 4776 Q14934 NFATC4 human S170 448860 GGAFFsPsPGsSSLS X -MAPK14 P38A Q16539 human CBX4 8535 O00257 CBX4 human T497 470079 SLQVkPEtPASAAVA X X -MAPK14 P38A Q16539 human USF1 7391 P22415 USF1 human T153 463815 EALLGQAtPPGTGQF X -MAPK14 P38A Q16539 human MAPKAPK2 17164 P49138 Mapkapk2 mouse T320 448273 QsTKVPQtPLHtsRV X 3007; 3041 -MAPK14 P38A Q16539 human XBP1 22433 O35426 Xbp1 mouse S61 21688102 RQRLTHLsPEEKALR bZIP_1 X -MAPK14 P38A Q16539 human MEF2C iso3 4208 Q06413-3 MEF2C human T300 448001 tPVVSVAtPTLPGQG X -MAPK14 P38A Q16539 human Rab7 7879 P51149 RAB7A human S72 468547 AGQERFQsLGVAFYR Ras X -MAPK14 P38A Q16539 human TBX2 21385 Q60707 Tbx2 mouse S336 1308918 PAREPPPsPSAAPsP TBX X X -MAPK14 P38A Q16539 human p53 7157 P04637 TP53 human S33 447531 LPENNVLsPLPsQAM X X 2526 -MAPK14 P38A Q16539 human MZF-1 109889 O70162 Mzf1 mouse S374 448856 SLSGQIQsPTTEGGF X -MAPK14 P38A Q16539 human SRC-3 8202 Q9Y6Q9 NCOA3 human S543 454108 SLLSTLSsPGPKLDN NCOA_u2 X -MAPK14 P38A Q16539 human AR 367 P10275 AR human S651 448414 GEASSTTsPTEETTQ X X -MAPK14 P38A Q16539 human p63 8626 Q9H3D4 TP63 human S162 451601 TFDALsPsPAIPSNT X 4981 -MAPK14 P38A Q16539 human osterix 170574 Q8VI67 Sp7 mouse S73 15334100 SSTNGLLsPAGsPPA X X -MAPK14 P38A Q16539 human Rb 5925 P06400 RB1 human T252 449821 PINGsPRtPRRGQNR X X -MAPK14 P38A Q16539 human MEF2A 4205 Q02078 MEF2A human S223 7533200 VPNGAGSsPVGNGFV X -MAPK14 P38A Q16539 human STAT3 6774 P40763 STAT3 human S727 448191 NtIDLPMsPrTLDSL X 9134; 9136; 34911; 94994; 49081; 58978; 87544; 71958; 50804 -MAPK14 P38A Q16539 human BUB3 9184 O43684 BUB3 human S211 452546 AVEyLDPsPEVQkkk X X -MAPK14 P38A Q16539 human FOXO3A 2309 O43524 FOXO3 human S425 2058400 TKGsGLGsPtSSFNS X 64616 -MAPK14 P38A Q16539 human CDT1 81620 Q9H211 CDT1 human S411 21440504 PAtPPAAsPsALkGV X X -MAPK14 P38A Q16539 human MEF2A 4205 Q02078 MEF2A human S408 449949 SIkSEPIsPPRDRMT X 9737 -MAPK14 P38A Q16539 human CDKN2D 1032 P55273 CDKN2D human S66 6046000 ELLKQGAsPNVQDTS Ank_2 X X -MAPK14 P38A Q16539 human UBE3C 100763 Q80U95 Ube3c mouse S741 1884003508 EDAYDKLsPENEPDL X -MAPK14 P38A Q16539 human Tel 2120 P41212 ETV6 human S22 468918 IsytPPEsPVPsyAs X -MAPK14 P38A Q16539 human SOX9 6662 P48436 SOX9 human S211 450957 FKALQADsPHsSSGM X -MAPK14 P38A Q16539 human GRHL3 57822 Q8TE85 GRHL3 human T454 1077816900 RPETDLEtPPVLFIP X -MAPK14 P38A Q16539 human DROSHA 29102 Q9NRR4 DROSHA human T274 25289827 sDyDrGRtPsRHRSY X X -MAPK14 P38A Q16539 human SIAH2 20439 Q06986 Siah2 mouse T24 471340 KQPPPPQtPHAPsPA X -MAPK14 P38A Q16539 human RBPJ 3516 Q06330 RBPJ human T339 23298201 STDKAEYtFYEGMGP X X -MAPK14 P38A Q16539 human p63 iso2 8626 Q9H3D4-2 TP63 human S66 451600 SSTFDALsPsPAIPS X X -MAPK14 P38A Q16539 human NHE1 6548 P19634 SLC9A1 human T718 4059100 KEDLPVItIDPAsPQ X -MAPK14 P38A Q16539 human Bcl-xL 598 Q07817 BCL2L1 human S62 449099 PSWHLADsPAVNGAT X -MAPK14 P38A Q16539 human GATA2 2624 P23769 GATA2 human S192 14573920 PsTTGAAsPASSSAG X -MAPK14 P38A Q16539 human SREBP-1 6720 P36956 SREBF1 human S63 23940711 AGGtDPAsPDTSSPG X X -MAPK14 P38A Q16539 human CRYAB 1410 P02511 CRYAB human S59 448783 PsFLRAPsWFDTGLS X -MAPK14 P38A Q16539 human eNOS 4846 P29474 NOS3 human S114 448638 RKLQGRPsPGPPAPE X X 9575 -MAPK14 P38A Q16539 human DDX5 1655 P17844 DDX5 human T564 27156800 SFRTGNPtGTYQNGY P68HR X -MAPK14 P38A Q16539 human Rb 5925 P06400 RB1 human S567 450021 SLAWLSDsPLFDLIk RB_A X X -MAPK14 P38A Q16539 human p21Cip1 1026 P38936 CDKN1A human S98 478193 GGRRPGTsPALLQGT X -MAPK14 P38A Q16539 human LAMP2 3920 P13473 LAMP2 human T213 386186606 PSPtttPtPKEKPEA X X -MAPK14 P38A Q16539 human ELK1 13712 P41969 Elk1 mouse S384 447872 IHFWSTLsPIAPRsP X 9181; 9186 -MAPK14 P38A Q16539 human Rb 5925 P06400 RB1 human S249 447975 AVIPINGsPRtPRRG X X -MAPK14 P38A Q16539 human MEF2D 4209 Q14814 MEF2D human S192 10941739 ALQRNSVsPGLPQRP X -MAPK14 P38A Q16539 human TRIM9 iso5 114088 Q9C026-5 TRIM9 human S80 1046182901 EADsGYGsYGGFASA X -MAPK14 P38A Q16539 human SREBP-1 6720 P36956 SREBF1 human T426 467200 TEVEDTLtPPPsDAG X X -MAPK14 P38A Q16539 human SMAD9 4093 O15198 SMAD9 human T136 15722873 YHYRRVEtPVLPPVL X -MAPK14 P38A Q16539 human Snail1 6615 O95863 SNAI1 human S107 455882 sQPPsPPsPAPssFS X X -MAPK14 P38A Q16539 human ULK1 22241 O70405 Ulk1 mouse S504 397383602 GGRPYTPsPQVGTIP X -MAPK14 P38A Q16539 human DDIT3 1649 P35638 DDIT3 human S82 448091 STSQsPHsPDSSQSS X -MAPK14 P38A Q16539 human ATF-2 11909 P16951 Atf2 mouse T51 448224 sVIVADQtPtPtRFL X X 9225; 94125; 40749; 61584; 44167 -MAPK14 P38A Q16539 human BMF 171543 Q91ZE9 Bmf mouse S74 11267001 DKATQtLsPAsPSQG BMF X X -MAPK14 P38A Q16539 human KHSRP 8570 Q92945 KHSRP human T692 458387 QAAyYGQtPGPGGPQ X -MAPK14 P38A Q16539 human DROSHA 29102 Q9NRR4 DROSHA human S300 14572630 RHRDNRRsPsLERSY X X -MAPK14 P38A Q16539 human ZNHIT1 10467 O43257 ZNHIT1 human T103 13419503 AEGPNYLtACAGPPS X X -MAPK14 P38A Q16539 human FOXO3A 2309 O43524 FOXO3 human S12 9318037 PAsPAPLsPLEVELD X -MAPK14 P38A Q16539 human p63 iso2 8626 Q9H3D4-2 TP63 human S301 451602 TSIKKRRsPDDELLY P53_tetramer X X -MAPK14 P38A Q16539 human GR 2908 P04150 NR3C1 human S226 451796 IDENCLLsPLAGEDD GCR X 97285 -MAPK14 P38A Q16539 human SKP2 6502 Q13309 SKP2 human S64 457412 sNLGHPEsPPRkRLk X 14865 -MAPK14 P38A Q16539 human BMF 171543 Q91ZE9 Bmf mouse S77 22999100 TQtLsPAsPSQGVML BMF X X -MAPK14 P38A Q16539 human Bcl-2 596 P10415 BCL2 human S87 448396 AAAGPALsPVPPVVH X X -MAPK14 P38A Q16539 human RBM17 84991 Q96I25 RBM17 human T71 470694 DDrQIVDtPPHVAAG X -MAPK14 P38A Q16539 human ATF6A 22926 P18850 ATF6 human T166 35527100 NKTENGLtPKKKIQV X X -MAPK14 P38A Q16539 human Kv2.1 25736 P15387 Kcnb1 rat S804 473562 ESsPLPTsPKFLRPN X -MAPK14 P38A Q16539 human PXN 5829 P49023 PXN human S85 451054 HQQPQsssPVyGsSA Paxillin X X -MAPK14 P38A Q16539 human MEF2A 4205 Q02078 MEF2A human S192 7533201 TTLHRNVsPGAPQRP X -MAPK14 P38A Q16539 human GR 2908 P04150 NR3C1 human S203 447967 DLEFSSGsPGkEtNE GCR X X -MAPK14 P38A Q16539 human BMF 171543 Q91ZE9 Bmf mouse T72 1874396402 QEDKATQtLsPAsPS BMF X -MAPK14 P38A Q16539 human Caldesmon 281660 NP_776683 CALD1 cow S531 448466 QSVDKVTsPTKV___ X -MAPK14 P38A Q16539 human MEF2A 4205 Q02078 MEF2A human S98 485623 KEHRGCDsPDPDtsy HJURP_C X -MAPK14 P38A Q16539 human MKL1 223701 Q8K4J6 Mrtfa mouse T488 469405 KFGsTGstPPVsPTP X -MAPK14 P38A Q16539 human Tau iso8 4137 P10636-8 MAPT human S202 447928 sGyssPGsPGtPGsR X X 39357; 30505 -MAPK14 P38A Q16539 human DROSHA 29102 Q9NRR4 DROSHA human S255 40274400 DRRERGRsPDRRRQD X X -MAPK14 P38A Q16539 human FOXC2 2303 Q99958 FOXC2 human S367 28129600 DHPSGPTsPLSALNL X X -MAPK14 P38A Q16539 human SREBP-1 iso3 6720 P36956-3 SREBF1 human S39 23940711 AGGTDPAsPDTSSPG X -MAPK14 P38A Q16539 human p21Cip1 1026 P38936 CDKN1A human S130 455618 sGEQAEGsPGGPGDs X X -MAPK14 P38A Q16539 human TAB1 10454 Q15750 TAB1 human S423 456222 QMVNGAHsASTLDEA X X -MAPK14 P38A Q16539 human KARS 3735 Q15046 KARS1 human T52 25692907 EKQLsQAtAAATNHT X X -MAPK14 P38A Q16539 human PIP4K2B 8396 P78356 PIP4K2B human S326 470107 SYGtPPDsPGNLLsF PIP5K X X -MAPK14 P38A Q16539 human SCS-beta 8803 Q9P2R7 SUCLA2 human S79 27457818 PKGyVAksPDEAyAI ATP-grasp_2 X X -MAPK14 P38A Q16539 human 4E-BP1 13685 Q60876 Eif4ebp1 mouse T36 447497 PPGDysttPGGtLFs eIF_4EBP X X 2855; 9459; 2846; 4923; 5123; 3929; 7547; 45613; 39788 -MAPK14 P38A Q16539 human FOXN3 1112 O00409 FOXN3 human S83 4930951 FGESVLRsVsPVQDL X X -MAPK14 P38A Q16539 human Kv2.1 3745 Q14721 KCNB1 human S800 473567 EKNHFESsPLPtsPK X -MAPK14 P38A Q16539 human p63 8626 Q9H3D4 TP63 human S395 451602 TSIKKRRsPDDELLY P53_tetramer X -MAPK14 P38A Q16539 human NHE1 6548 P19634 SLC9A1 human S723 2509103 VItIDPAsPQsPEsV X -MAPK14 P38A Q16539 human HSP27 3315 P04792 HSPB1 human S176 26352800 MPkLAtQsNEItIPV HSP20 X -MAPK14 P38A Q16539 human ER-alpha 2099 P03372 ESR1 human S118 448101 LHPPPQLsPFLQPHG Oest_recep X 2511 -MAPK14 P38A Q16539 human PXN 360820 Q66H76 Pxn rat S83 451113 yAHQQPPsPSPIySS Paxillin X -MAPK14 P38A Q16539 human SNX27 81609 Q96L92 SNX27 human S51 486072 VRIVksEsGYGFNVR PDZ X X -MAPK14 P38A Q16539 human MAPKAPK5 17165 O54992 Mapkapk5 mouse T182 450093 VDQGDLMtPQFTPYY Pkinase X -MAPK14 P38A Q16539 human MKL1 57591 Q969V6 MRTFA human S333 3208578 CGLARQNstsLtGKP X -MAPK14 P38A Q16539 human osterix 170574 Q8VI67 Sp7 mouse S77 15334101 GLLsPAGsPPAPASG X X -MAPK14 P38A Q16539 human AGO2 27161 Q9UKV8 AGO2 human S387 472450 SkLMRsAsFNtDPyV ArgoL2 X -MAPK14 P38A Q16539 human MED17 234959 Q8VCD5 Med17 mouse T568 63083901 IGNASAItVASPSGD X -MAPK14 P38A Q16539 human p47phox 653361 P14598 NCF1 human S345 451727 QARPGPQsPGsPLEE X X -MAPK14 P38A Q16539 human GSK3B 2932 P49841 GSK3B human T390 452320 RIQAAAstPtNAtAA X X 3548 -MAPK14 P38A Q16539 human FOXN3 1112 O00409 FOXN3 human S85 454694 ESVLRsVsPVQDLDD X X -MAPK14 P38A Q16539 human TBX2 21385 Q60707 Tbx2 mouse S675 1308916 GPsRGALsPSGsAKE X X -MAPK14 P38A Q16539 human Mnk1 8569 Q9BUB5 MKNK1 human T255 447622 ITtPELTtPCGSAEY Pkinase X 2111; 43507 -MAPK14 P38A Q16539 human ER-alpha 2099 P03372 ESR1 human S294 451560 RAANLWPsPLMIkRS X X -MAPK14 P38A Q16539 human NHE1 6548 P19634 SLC9A1 human S729 3181649 AsPQsPEsVDLVNEE X X -MAPK14 P38A Q16539 human DROSHA 29102 Q9NRR4 DROSHA human S221 23100760 KAPSERRsPERLKHy X X -MAPK14 P38A Q16539 human BIM 64547 O88498 Bcl2l11 rat S65 449330 GPLAPPAsPGPFATR X X 4581; 4585 -MAPK14 P38A Q16539 human SRC-3 8202 Q9Y6Q9 NCOA3 human S867 454107 sPVsVGssPPVKNIS X -MAPK14 P38A Q16539 human MSK1 73086 Q8C050 Rps6ka5 mouse T764 471413 LssNPLMtPDILGSS X -MAPK14 P38A Q16539 human LIMK1 3984 P53667 LIMK1 human S310 459629 PGAGsLGsPAsQRKD X -MAPK14 P38A Q16539 human TWIST1 7291 Q15672 TWIST1 human S68 18905000 GGGDEPGsPAQGkRG X X -MAPK14 P38A Q16539 human MEF2A 4205 Q02078 MEF2A human T312 448097 QATQPLAtPVVSVTt X -MAPK14 P38A Q16539 human MAPKAPK2 9261 P49137 MAPKAPK2 human T222 448269 tSHNsLttPCytPYY Pkinase X X 3316 -MAPK14 P38A Q16539 human RORA 19883 P51448 Rora mouse S100 1212279800 CKGFFRRsQQSNATY zf-C4 X -MAPK14 P38A Q16539 human MEF2D 17261 Q63943 Mef2d mouse S190 2246701 QPALQRNsVsPGLPQ X -MAPK14 P38A Q16539 human MSK1 9252 O75582 RPS6KA5 human S360 448215 TEMDPTYsPAALPQS Pkinase_C X 9594 -MAPK14 P38A Q16539 human MAOA 4128 P21397 MAOA human S209 9726600 GGTTRIFsVTNGGQE Amino_oxidase X -MAPK14 P38A Q16539 human ZAP70 7535 P43403 ZAP70 human T293 478058 tLNsDGytPEPARIt X X -MAPK14 P38A Q16539 human HePTP 5778 P35236 PTPN7 human T66 448311 EPICsVNtPREVTLH X -MAPK14 P38A Q16539 human HSF1 3297 Q00613 HSF1 human S307 449046 EPPsPPQsPRVEEAs Vert_HS_TF X -MAPK14 P38A Q16539 human p57Kip2 iso2 12577 P49919-2 Cdkn1c mouse T143 25525402 AEPTPPAtPAPASDL X X -MAPK14 P38A Q16539 human RCAN1 54720 Q9JHG6 Rcan1 mouse S146 25687504 AQTLHIGsSHLAPPN Calcipressin X -MAPK14 P38A Q16539 human BTG2 12227 Q04211 Btg2 mouse S149 1709500 MLGRSsPsKNYVMAV X -MAPK14 P38A Q16539 human DROSHA 29102 Q9NRR4 DROSHA human S355 30985044 LEIVNHRsPsREKKR X X -MAPK14 P38A Q16539 human TAB1 10454 Q15750 TAB1 human S457 22869800 TQssSSssDGGLFRS X X -MAPK14 P38A Q16539 human MEF2A 4205 Q02078 MEF2A human S479 4957257 DPRGDFHsPIVLGRP X -MAPK14 P38A Q16539 human PAK6 56924 Q9NQU5 PAK6 human S165 454427 MPWPEPQsPRVLPNG X -MAPK14 P38A Q16539 human EGFR 1956 P00533 EGFR human S1039 3178884 tPLLSsLsAtsNNst X -MAPK14 P38A Q16539 human MEF2C iso3 4208 Q06413-3 MEF2C human S387 1729600 TRHEAGRsPVDSLSS X -MAPK14 P38A Q16539 human CASP3 836 P42574 CASP3 human S150 450984 FRGDRCRsLtGKPKL Peptidase_C14 X X -MAPK14 P38A Q16539 human Stargazin 84347 Q71RJ2 Cacng2 rat T321 451273 NTANRRTtPV_____ X -MAPK14 P38A Q16539 human NFAT3 73181 Q8K120 Nfatc4 mouse S170 448860 GGAFFsPsPGSSSLS X -MAPK14 P38A Q16539 human ER-alpha 2099 P03372 ESR1 human T311 449929 NsLALSLtADQMVSA X X -MAPK14 P38A Q16539 human Tau iso8 4137 P10636-8 MAPT human T181 447932 ktPPAPktPPssGEP X 12885; 66224; 62672 -MAPK14 P38A Q16539 human coronin 1B 57175 Q9BR76 CORO1B human S2 456131 ______MsFRKVVRQ X X -MAPK14 P38A Q16539 human TBX2 21385 Q60707 Tbx2 mouse S623 1308917 ArPrLRFsPYQIPVT X X -MAPK14 P38A Q16539 human DLX5 13395 P70396 Dlx5 mouse S34 1725302 MHHPSQEsPTLPESS DLL_N X X -MAPK14 P38A Q16539 human P38A 26416 P47811 Mapk14 mouse Y182 447971 tDDEMtGyVAtRWYR Pkinase X 9211; 9215; 4551; 9216; 4552; 4631; 4511; 4092; 9219; 24678; 8632; 6908; 41768; 51255; 14594; 14598; 62979 -MAPK14 P38A Q16539 human EGFR 1956 P00533 EGFR human T693 448054 RELVEPLtPsGEAPN X 3056; 8808 -MAPK14 P38A Q16539 human Mnk1 iso2 8569 Q9BUB5-2 MKNK1 human T209 447621 NSCTPITtPELTtPC Pkinase X 2111; 43507 -MAPK14 P38A Q16539 human Rb 5925 P06400 RB1 human S838 14160962 ILVsIGEsFGtsEkF Rb_C X X -MAPK14 P38A Q16539 human MAPKAPK5 8550 Q8IW41 MAPKAPK5 human T182 450093 IDQGDLMtPQFtPyY Pkinase X -MAPK14 P38A Q16539 human MEF2D 17261 Q63943 Mef2d mouse S121 2246700 EDKYRRAsEELDGLF HJURP_C X -MAPK14 P38A Q16539 human STMN1 29332 P13668 Stmn1 rat S25 448555 QAFELILsPRSKESV Stathmin X -MAPK14 P38A Q16539 human GSK3B 2932 P49841 GSK3B human S389 454221 ARIQAAAstPtNAtA X -MAPK14 P38A Q16539 human ATF-2 11909 P16951 Atf2 mouse T53 448225 IVADQtPtPtRFLKN X X 9225; 9221; 5112; 94125; 13850; 40749; 15411; 24329; 61584; 27934; 92109; 20534; 35858 -MAPK14 P38A Q16539 human FOXO3A 2309 O43524 FOXO3 human S344 2058401 QDDDAPLsPMLYSSS X -MAPK14 P38A Q16539 human ELK4 2005 P28324 ELK4 human S381 4317600 IHFWSTLsPVAPLsP X X -MAPK14 P38A Q16539 human XBP1 22433 O35426 Xbp1 mouse T48 21688103 AGSEASGtPQARKRQ X -MAPK14 P38A Q16539 human MZF-1 109889 O70162 Mzf1 mouse S354 448855 TAEPDMMsPHLHVPW X -MAPK14 P38A Q16539 human NALP1 22861 Q9C000 NLRP1 human S107 1880261804 PSEPHLGsPSQPTST X -MAPK14 P38A Q16539 human GJA1 2697 P17302 GJA1 human S279 448853 sSPtAPLsPMsPPGy X -MAPK14 P38A Q16539 human HSF1 3297 Q00613 HSF1 human S303 449045 RVkEEPPsPPQsPRV Vert_HS_TF X -MAPK14 P38A Q16539 human CDT1 81620 Q9H211 CDT1 human S491 21440505 GSCCTIMsPGEMEKH CDT1_C X X -MAPK14 P38A Q16539 human Tip60 iso2 10524 Q92993-2 KAT5 human T106 10800707 VEVVsPAtPVPSETA X -MAPK14 P38A Q16539 human SHC1 20416 P98083 Shc1 mouse S36 448508 TPPEELPsPSASSLG X -MAPK14 P38A Q16539 human MAFA 389692 Q8NHW3 MAFA human T134 456029 NPEALNLtPEDAVEA Maf_N X -MAPK14 P38A Q16539 human MEF2A 4205 Q02078 MEF2A human T108 485622 PDtsyVLtPHtEEKy HJURP_C X -MAPK14 P38A Q16539 human HNF4 alpha 3172 P41235 HNF4A human S167 458371 VLSRQItsPVsGING X X -MAPK14 P38A Q16539 human SCN8A 20273 Q9WTU3 Scn8a mouse S553 456209 SLLSIPGsPFLSRHN Na_trans_cytopl X -MAPK14 P38A Q16539 human GSK3B 56637 Q9WV60 Gsk3b mouse S389 454221 ARIQAAAsPPANAtA X -MAPK14 P38A Q16539 human PARK2 5071 O60260 PRKN human S131 454421 HTDsRkDsPPAGsPA X -MAPK14 P38A Q16539 human MDM4 4194 O15151 MDM4 human S314 62381100 TECKKFNsPSKRYCF zf-RanBP X -MAPK14 P38A Q16539 human NFAT2 4772 O95644 NFATC1 human S172 465577 YRDPsCLsPASSLSS X -MAPK14 P38A Q16539 human RCAN1 54720 Q9JHG6 Rcan1 mouse S165 456023 FLIsPPAsPPVGWKQ Calcipressin X -MAPK14 P38A Q16539 human PDX1 3651 P52945 PDX1 human S61 458401 LGALEQGsPPDIsPY X -MAPK14 P38A Q16539 human EEA1 8411 Q15075 EEA1 human T1392 456871 CSAKNALtPSSKKPV FYVE X X -MAPK14 P38A Q16539 human TIF1B 10155 Q13263 TRIM28 human S473 452391 sGVkRsRsGEGEVsG X -MAPK14 P38A Q16539 human F3 2152 P13726 F3 human S290 451613 GQsWkENsPLNVs__ X X -MAPK14 P38A Q16539 human MSK2 8986 O75676 RPS6KA4 human S196 450046 EEkERtFsFCGTIEY Pkinase X -MAPK14 P38A Q16539 human GJA1 2697 P17302 GJA1 human S282 448854 tAPLsPMsPPGykLV X -MAPK14 P38A Q16539 human CRYAB 12955 P23927 Cryab mouse S59 448783 PSFLRAPsWIDtGLS X -MAPK14 P38A Q16539 human TAB1 10454 Q15750 TAB1 human S453 22869803 TNTHTQssSSssDGG X X -MAPK14 P38A Q16539 human MAPKAPK2 9261 P49137 MAPKAPK2 human T25 448271 APPPQPPtPALPHPP X -MAPK14 P38A Q16539 human MKL1 223701 Q8K4J6 Mrtfa mouse S487 4762839 VKFGsTGstPPVsPT X -MAPK14 P38A Q16539 human MEF2D 4209 Q14814 MEF2D human S231 3196574 GYVsARAsPGLLPVA X -MAPK14 P38A Q16539 human E2F4 E1BUH4 E2F4 chicken T261 25571901 PSSTQPStPtPSSTQ X -MAPK14 P38A Q16539 human HSF1 3297 Q00613 HSF1 human S326 455484 ssVDtLLsPTALIDs Vert_HS_TF X X -MAPK14 P38A Q16539 human TAB1 10454 Q15750 TAB1 human S438 456224 tPTLTNQsPTLtLQS X X -MAPK14 P38A Q16539 human MAPKAPK2 9261 P49137 MAPKAPK2 human T334 448273 QstKVPQtPLHtsRV X X 3007; 3041 -MAPK14 P38A Q16539 human MSK1 9252 O75582 RPS6KA5 human T581 448217 PDNQPLKtPCFTLHY Pkinase X 9595 -MAPK14 P38A Q16539 human IFNAR1 3454 P17181 IFNAR1 human S532 11927800 KKySSQTsQDsGNys X X -MAPK14 P38A Q16539 human MKL1 57591 Q969V6 MRTFA human S312 10989194 tPPVRsLstTNSsSS X -MAPK14 P38A Q16539 human TFEB 21425 Q9R210 Tfeb mouse S400 1880515602 LDFSHGLsFGGGGDE X X -MAPK14 P38A Q16539 human NOXA1 10811 Q86UR1 NOXA1 human S282 12570900 VGKQAPLsPGLPAMG X X -MAPK14 P38A Q16539 human Bcl-2 596 P10415 BCL2 human T56 448655 FSSQPGHtPHPAASR X X 2875 -MAPK14 P38A Q16539 human CCND2 894 P30279 CCND2 human T280 469202 DELDQAstPtDVRDI Cyclin_C X X -MAPK14 P38A Q16539 human LAMP2 3920 P13473 LAMP2 human T211 386186605 tVPSPtttPtPKEKP X X -MAPK14 P38A Q16539 human MEF2D 4209 Q14814 MEF2D human S450 27452873 VsPsRERsPAPPPPA X -MAPK14 P38A Q16539 human ELK1 2002 P19419 ELK1 human S383 447872 IHFWSTLsPIAPRsP X X 9181; 9186 -MAPK14 P38A Q16539 human p53 7157 P04637 TP53 human S15 447490 PsVEPPLsQEtFsDL P53_TAD X X 4030; 9235; 9284; 9286; 8695; 8514; 82530; 56979 -MAPK14 P38A Q16539 human TRIM9 iso5 114088 Q9C026-5 TRIM9 human S76 1046182900 SLYSEADsGYGsYGG X -MAPK14 P38A Q16539 human ZFYVE20 64145 Q9H1K0 RBSN human S215 457605 EsLSTHtsPsQsPNs FYVE X X -MAPK14 P38A Q16539 human PKCE 5581 Q02156 PRKCE human S350 486055 RsKsAPtsPCDQEIK X -MAPK14 P38A Q16539 human F3 2152 P13726 F3 human S285 451611 RKAGVGQsWkENsPL X -MAPK14 P38A Q16539 human RCAN1 54720 Q9JHG6 Rcan1 mouse S161 456022 PDKQFLIsPPAsPPV Calcipressin X -MAPK14 P38A Q16539 human Oct7 5454 P20265 POU3F2 human S91 1868139200 GGGGGDGsPWSTSPL X -MAPK14 P38A Q16539 human FOXC1 2296 Q12948 FOXC1 human S272 460580 SSLSSGSsPPGSLPS X -MAPK14 P38A Q16539 human MFF 56947 Q9GZY8 MFF human S155 470753 GRLkRERsMsENAVR Miff X X -MAPK14 P38A Q16539 human TAO2 iso2 64666 Q9JLS3-2 tao2 rat S1038 1308925 AAVPGPLsRSTSVAS X -MAPK14 P38A Q16539 human EZH2 2146 Q15910 EZH2 human T367 466987 NNssRPstPtINVLE X X -MAPK14 P38A Q16539 human Tau iso8 4137 P10636-8 MAPT human T205 447933 ssPGsPGtPGsRsRt X X 25377; 43964; 53001; 49561; 20060; 33032; 30505; 20739; 98160 -MAPK14 P38A Q16539 human SREBP-1 iso3 6720 P36956-3 SREBF1 human T402 467200 TEVEDTLtPPPSDAG X -MAPK14 P38A Q16539 human NFAT3 73181 Q8K120 Nfatc4 mouse S168 448859 QGGGAFFsPsPGSSS X -MAPK14 P38A Q16539 human SOX2 20674 P48432 Sox2 mouse S253 6738002 VksEASSsPPVVtSS X 92186 -MAPK14 P38A Q16539 human Kv7.2 iso4 3785 O43526-4 KCNQ2 human S427 15721018 VAAKGKGsPQAQTVR X -MAPK14 P38A Q16539 human MSK1 73086 Q8C050 Rps6ka5 mouse T645 448217 PDNQPLKtPCFTLHY Pkinase X 9595 -MAPK14 P38A Q16539 human EWS 2130 Q01844 EWSR1 human T79 7359501 QPPTGYTtPTAPQAY X X -MAPK14 P38A Q16539 human PGC-1 alpha 10891 Q9UBK2 PPARGC1A human S266 448008 SLPLtPEsPNDPKGs X X -MAPK14 P38A Q16539 human BACE 23621 P56817 BACE1 human S83 55367300 YVEMTVGsPPQTLNI Asp X -MAPK14 P38A Q16539 human CDT1 81620 Q9H211 CDT1 human T406 21440503 LPAtPPAtPPAAsPs X X -MAPK14 P38A Q16539 human Tau iso8 4137 P10636-8 MAPT human S422 449083 GsIDMVDsPQLAtLA X X -MAPK14 P38A Q16539 human SCN10A Q62968 Scn10a rat S551 2482300 QTGPLPRsPLPQsPN X X -MAPK14 P38A Q16539 human p21Cip1 1026 P38936 CDKN1A human T57 451222 NFDFVtEtPLEGDFA CDI X -MAPK14 P38A Q16539 human HuR 1994 Q15717 ELAVL1 human S88 474552 LNGLRLQskTIkVSY RRM_1 X -MAPK14 P38A Q16539 human eIF2-alpha 1965 P05198 EIF2S1 human S52 447635 MILLsELsRRRIRsI S1 X 3597; 9721; 3398; 5199; 53085; 95797 -MAPK14 P38A Q16539 human Tip60 10524 Q92993 KAT5 human T158 10800707 VEVVsPAtPVPSETA X -MAPK14 P38A Q16539 human AML3 iso5 12393 Q08775-5 Runx2 mouse S319 10892802 SYLSQMTsPSIHSTt X -MAPK14 P38A Q16539 human SRC-3 8202 Q9Y6Q9 NCOA3 human S505 454109 SPVAGVHsPMAsSGN NCOA_u2 X -MAPK14 P38A Q16539 human GR 2908 P04150 NR3C1 human S211 447968 PGkEtNEsPWRSDLL GCR X X 4161 -MAPK14 P38A Q16539 human MAP4 4134 P27816 MAP4 human S787 448480 KAPEkRAsPsKPAsA X -MAPK14 P38A Q16539 human TXNIP 10628 Q9H3M7 TXNIP human S361 3212304 DMDGsQDsPIFMYAP X -MAPK14 P38A Q16539 human MEF2A 4205 Q02078 MEF2A human S494 4728294 PNTEDREsPsVKRMR X -MAPK14 P38A Q16539 human AML3 12393 Q08775 Runx2 mouse S107 3053615 PSTSRRFsPPSssLQ X -MAPK14 P38A Q16539 human MAP4 17758 P27546 Map4 mouse S760 448480 KVAEKRtsPsKPssA X -MAPK14 P38A Q16539 human STAT1 20846 P42225 Stat1 mouse S727 447753 tDNLLPMsPEEFDEM STAT1_TAZ2bind X X 9177; 8826; 62390 -MAPK14 P38A Q16539 human SMARCD3 66993 Q6P9Z1 Smarcd3 mouse T229 8097074 HLVEWHRtPTTQETD X -MAPK14 P38A Q16539 human MEF2C iso3 4208 Q06413-3 MEF2C human T293 448000 QSAQSLAtPVVSVAt X -MAPK14 P38A Q16539 human p63 8626 Q9H3D4 TP63 human S455 451603 QKQtSIQsPSSYGNs X -Akt3 Akt3 Q9WUA6 mouse DAPK2 13143 Q8VDF3 Dapk2 mouse T369 487231 HPRRRssts______ X -Dapk1 DAPK1 F1LNN8 rat NMDAR2B 24410 Q00960 Grin2b rat S1303 450171 NKLRRQHsyDtFVDL NMDAR2_C X 20274; 71335 -PIK3CA PIK3CA P32871 cow PIK3R1 282307 P23727 PIK3R1 cow S608 448133 ENTEDQYsLVEDDED X -AAK1 AAK1 Q2M2I8 human AP2M1 1173 Q96CW1 AP2M1 human T156 448782 SQItsQVtGQIGWRR X 3843; 7399 -AAK1 AAK1 Q2M2I8 human AP2M1 11773 P84091 Ap2m1 mouse T156 448782 SQITsQVtGQIGWRR X 3843; 7399 -AAK1 AAK1 Q2M2I8 human NUMB 8650 P49757 NUMB human T102 3333403 LRVVDEKtKDLIVDQ PID X X -FES Fes P07332 human Fes 2242 P07332 FES human Y811 448354 RPSFSTIyQELQSIR PK_Tyr_Ser-Thr X X -FES Fes P07332 human Bcr 613 P11274 BCR human Y246 447793 sCGVDGDyEDAELNP X -FES Fes P07332 human PECAM-1 18613 Q08481 Pecam1 mouse Y717 465455 PNLMENRysRTEGSL X -FES Fes P07332 human Fes 2242 P07332 FES human Y713 448353 REEADGVyAAsGGLR PK_Tyr_Ser-Thr X X -FES Fes P07332 human CRMP-2 25416 P47942 Dpysl2 rat Y32 463168 VNDDQSFyADIYMED X -FES Fes P07332 human NSF 4905 P46459 NSF human Y83 453414 QEIEVSLyTFDKAKQ CDC48_N X -WNK4 WNK4 Q96J92 human Claudin-7 1366 O95471 CLDN7 human S206 486329 RsYPksNsskEyV__ X -WNK4 WNK4 Q96J92 human STLK3 53416 Q9Z1W9 Stk39 mouse S382 1984125 KVRRVPGssGHLHKT X -WNK4 WNK4 Q96J92 human NCCT 6559 P55017 SLC12A3 human T50 4709842 SHLtHSStFCMRtFG AA_permease_N X -WNK4 WNK4 Q96J92 human NCCT 20497 P59158 Slc12a3 mouse T48 4709842 sHLtHGstLyMRtFG AA_permease_N X -WNK4 WNK4 Q96J92 human WNK4 65266 Q96J92 WNK4 human S335 456207 kRAsFAKsVIGTPEF Pkinase X -WNK4 WNK4 Q96J92 human NCCT 6559 P55017 SLC12A3 human T46 2286406 SSHPSHLtHSStFCM AA_permease_N X -WNK4 WNK4 Q96J92 human NCCT 6559 P55017 SLC12A3 human T55 469616 SStFCMRtFGYNtID AA_permease_N X -SRC Src P00523 chicken CACNA1B 374169 Q9PUM6 CACNA1B chicken Y815 454440 DPEERVRyATTLHIR X -SRC Src P00523 chicken P130Cas 25414 Q63767 Bcar1 rat Y485 451539 RPGPGTLyDVPRERV X -SRC Src P00523 chicken FAK 396416 Q00944 PTK2 chicken Y926 447966 DRSNDKVyENVTGLV Focal_AT X X 3284 -SRC Src P00523 chicken P130Cas iso2 25414 Q63767-2 Bcar1 rat Y169 448722 PSPATDLyQVPPGPG X -SRC Src P00523 chicken RAF1 396245 P05625 RAF1 chicken Y340 447749 RGQRDssyyWEIEAS X -SRC Src P00523 chicken P130Cas iso2 25414 Q63767-2 Bcar1 rat Y132 448778 SKTQQGLyQAPGPNP X -SRC Src P00523 chicken TRPC3 7222 Q13507 TRPC3 human Y299 458805 KGLASPAyLSLSSED X -SRC Src P00523 chicken P130Cas 25414 Q63767 Bcar1 rat Y347 448721 APGSQDIyDVPPVRG X 4014 -SRC Src P00523 chicken PXN 395832 P49024 PXN chicken Y40 449965 YPTGNHTyQEIAVPP X -SRC Src P00523 chicken CACNA1B 374169 Q9PUM6 CACNA1B chicken Y804 454439 RASCEALyNELDPEE X -SRC Src P00523 chicken FAK 396416 Q00944 PTK2 chicken Y576 447889 RyMEDSTyyKASKGK PK_Tyr_Ser-Thr X 3281 -SRC Src P00523 chicken DGKA 1606 P23743 DGKA human Y335 486452 ILPPSSIyPSVLASG X -SRC Src P00523 chicken TRPC3 7222 Q13507 TRPC3 human Y221 458803 ELQDDDFyAyDEDGT TRP_2 X -SRC Src P00523 chicken RAF1 396245 P05625 RAF1 chicken Y341 447750 GQRDssyyWEIEASE X -SRC Src P00523 chicken RAF1 5894 P04049 RAF1 human Y341 447750 GQRDssyyWEIEASE X -SRC Src P00523 chicken GRF-1 232906 Q91YM2 Arhgap35 mouse Y1105 448941 RNEEENIysVPHDST RhoGAP_pG1_pG2 X -SRC Src P00523 chicken P130Cas 25414 Q63767 Bcar1 rat Y277 11997200 GSPAQDIyQVPPSAG X -SRC Src P00523 chicken TRPC3 7222 Q13507 TRPC3 human Y122 458802 RFLDAAEyGNIPVVR Ank_2 X -SRC Src P00523 chicken P130Cas iso2 25414 Q63767-2 Bcar1 rat Y414 448720 SVIDDGVyAVPPPAE X -SRC Src P00523 chicken P130Cas 25414 Q63767 Bcar1 rat Y226 448778 SKTQQGLyQAPGPNP X -SRC Src P00523 chicken P130Cas 25414 Q63767 Bcar1 rat Y385 451538 RDPLLDVyDVPPSVE X -SRC Src P00523 chicken P130Cas iso2 25414 Q63767-2 Bcar1 rat Y238 449639 SQAEQDEyDTPRHLL X -SRC Src P00523 chicken P130Cas iso2 25414 Q63767-2 Bcar1 rat Y391 451539 RPGPGTLyDVPRERV X -SRC Src P00523 chicken P130Cas iso2 25414 Q63767-2 Bcar1 rat Y196 6153351 AGTGHDIyQVPPSLD X -SRC Src P00523 chicken PXN 395832 P49024 PXN chicken Y31 448785 FLTEEtPySYPTGNH X -SRC Src P00523 chicken JIP3 iso2 30957 Q9ESN9-2 Mapk8ip3 mouse Y569 450240 YPSVNIHyKSPTAAG X -SRC Src P00523 chicken PXN 395832 P49024 PXN chicken Y88 448909 PQsQsPIysssAKss Paxillin X -SRC Src P00523 chicken P130Cas 25414 Q63767 Bcar1 rat Y404 448779 PSNHHSVyDVPPSVS X -SRC Src P00523 chicken P130Cas 25414 Q63767 Bcar1 rat Y365 451537 NQYGQEVyDTPPMAV X -SRC Src P00523 chicken TRPC3 7222 Q13507 TRPC3 human Y223 458804 QDDDFyAyDEDGTRF TRP_2 X -SRC Src P00523 chicken P130Cas iso2 25414 Q63767-2 Bcar1 rat Y310 448779 PSNHHSVyDVPPSVS X -SRC Src P00523 chicken P130Cas 25414 Q63767 Bcar1 rat Y290 6153351 AGTGHDIyQVPPSLD X -SRC Src P00523 chicken P130Cas iso2 25414 Q63767-2 Bcar1 rat Y183 11997200 GSPAQDIyQVPPSAG X -SRC Src P00523 chicken P130Cas iso2 25414 Q63767-2 Bcar1 rat Y271 451537 NQYGQEVyDTPPMAV X -SRC Src P00523 chicken P130Cas 25414 Q63767 Bcar1 rat Y508 448720 SVIDDGVyAVPPPAE X 4011 -SRC Src P00523 chicken RAF1 5894 P04049 RAF1 human Y340 447749 RGQRDssyyWEIEAS X -SRC Src P00523 chicken P130Cas 25414 Q63767 Bcar1 rat Y332 449639 SQAEQDEyDTPRHLL X -SRC Src P00523 chicken P130Cas iso2 25414 Q63767-2 Bcar1 rat Y253 448721 APGSQDIyDVPPVRG X -SRC Src P00523 chicken JIP3 iso2 30957 Q9ESN9-2 Mapk8ip3 mouse Y663 448671 KNVPVPVyCRPLVEK X -SRC Src P00523 chicken P130Cas iso2 25414 Q63767-2 Bcar1 rat Y291 451538 RDPLLDVyDVPPSVE X -SRC Src P00523 chicken JIP3 iso2 30957 Q9ESN9-2 Mapk8ip3 mouse Y616 448670 REQKREQyRQVREHV X -SRC Src P00523 chicken Kv2.1 25736 P15387 Kcnb1 rat Y128 449085 YWGIDEIyLESCCQA BTB_2 X -SRC Src P00523 chicken Src 396442 P00523 SRC chicken Y416 448234 RLIEDNEyTARQGAK PK_Tyr_Ser-Thr X 2101; 59548; 70926; 78740; 94361; 17320 -SRC Src P00523 chicken CDK1 983 P06493 CDK1 human Y15 447610 EkIGEGtyGVVykGR Pkinase X 4539; 9111; 14566; 77897 -SRC Src P00523 chicken Lasp-1 3927 Q14847 LASP1 human Y171 451675 IPtsAPVyQQPQQQP X X -SRC Src P00523 chicken P130Cas 25414 Q63767 Bcar1 rat Y263 448722 PSPATDLyQVPPGPG X 4015 -CHUK IKKA O15111 human SRC-3 8202 Q9Y6Q9 NCOA3 human S857 453084 PPYNRAVsLDsPVsV X -CHUK IKKA O15111 human Nik 9020 Q99558 MAP3K14 human S820 27259015 PsKAsQSsRDTLSSG X -CHUK IKKA O15111 human NFkB-p105 4790 P19838 NFKB1 human S923 447769 DELRDSDsVCDsGVE X -CHUK IKKA O15111 human RORC iso2 19885 P51450-2 Rorc mouse S376 139835702 GCSELISsIFDFSHF Hormone_recep X -CHUK IKKA O15111 human mTOR 2475 P42345 MTOR human S1418 15721416 AILEsLIsINNKLQQ X -CHUK IKKA O15111 human FOXA2 3170 Q9Y261 FOXA2 human S107 22825100 AGMGPHLsPSLsPLG Forkhead_N X X -CHUK IKKA O15111 human p27Kip1 12576 P46414 Cdkn1b mouse T183 23128659 DGsPNAGtVEQtPKK X -CHUK IKKA O15111 human ATG16L1 55054 Q676U5 ATG16L1 human S278 15425208 PAGGLLDsITNIFGR X X 45511; 84300 -CHUK IKKA O15111 human COPS5 10987 Q92905 COPS5 human S201 1827354807 kPPDEGPsEyQtIPL X X -CHUK IKKA O15111 human CTNNB1 1499 P35222 CTNNB1 human S37 447582 yLDsGIHsGATtTAP X 9561; 2009; 4270; 13537; 41334; 60180 -CHUK IKKA O15111 human PIAS1 56469 O88907 Pias1 mouse S90 479880 SPMPPTLsPSTIPQL X -CHUK IKKA O15111 human MTURN 222166 Q8N3F0 MTURN human S58 149319100 GDNFHVWsESEDCLP DUF4581 X -CHUK IKKA O15111 human H3 8350 P68431 H3C1 human S10 455676 tkQtArkstGGkAPr Histone X 9701; 9711; 9606; 3465; 3642; 3377; 3475; 3458; 5764; 47398; 8481; 8552; 53348; 29237; 66065; 43185; 64522; 52725 -CHUK IKKA O15111 human CTNNB1 1499 P35222 CTNNB1 human S45 447488 GATtTAPsLsGkGNP X 9565; 9564; 24710; 70034; 19807; 96727; 77605 -CHUK IKKA O15111 human CBP 1387 Q92793 CREBBP human S1382 478512 MkSRFVDsGEMsESF HAT_KAT11 X X -CHUK IKKA O15111 human mTOR 2475 P42345 MTOR human S1415 25745815 PTPAILEsLIsINNK X X -CHUK IKKA O15111 human NFkB-p65 5970 Q04206 RELA human S536 447800 sGDEDFSsIADMDFS X X 4887; 3036; 3031; 4886; 3033; 4025; 5733; 13346; 76778; 31553; 80477; 73992; 87672; 83962 -CHUK IKKA O15111 human HuR 1994 Q15717 ELAVL1 human S304 27156803 EAAMAIAsLNGYRLG RRM_1 X -CHUK IKKA O15111 human N-CoR1 20185 Q60974 Ncor1 mouse S2348 2888301 NKSNsRKsKsPIPGQ X -CHUK IKKA O15111 human IKKA 12675 Q60680 Chuk mouse S176 447778 AKDVDQGsLCTsFVG Pkinase X 2078; 2697; 14938; 92255; 36516; 36214 -CHUK IKKA O15111 human CCND1 595 P24385 CCND1 human T286 447839 EEVDLACtPtDVRDV X X 3300; 94159 -CHUK IKKA O15111 human Bcl-3 602 P20749 BCL3 human S454 31867760 PsPAPGGs_______ X -CHUK IKKA O15111 human FOXA2 3170 Q9Y261 FOXA2 human S111 22825101 PHLsPSLsPLGGQAA Forkhead_N X X -CHUK IKKA O15111 human NFkB-p100 4791 Q00653 NFKB2 human S870 450167 kEDsAyGsQsVEQEA X X 4810 -CHUK IKKA O15111 human TAX1BP1 iso2 8887 Q86VP1-2 TAX1BP1 human S593 12738639 NYKELKRsLENPAER X -CHUK IKKA O15111 human Myc 4609 P01106 MYC human S82 4967400 PLsPsRRsGLCsPSy Myc_N X X -CHUK IKKA O15111 human COPS5 10987 Q92905 COPS5 human T205 1827354804 EGPsEyQtIPLNkIE X X -CHUK IKKA O15111 human IkB-alpha 4792 P25963 NFKBIA human S32 448203 LLDDRHDsGLDsMkD X X 5210; 2859; 9246; 5209 -CHUK IKKA O15111 human FOXO3A 2309 O43524 FOXO3 human S644 451438 GLDFNFDsLISTQNV FOXO-TAD X -CHUK IKKA O15111 human REL 5966 Q04864 REL human S557 480318 SNTTVFVsQSDAFEG X -CHUK IKKA O15111 human NFkB-p105 4790 P19838 NFKB1 human S927 447770 DSDsVCDsGVETsFR X X -CHUK IKKA O15111 human Myc 4609 P01106 MYC human S86 449991 sRRsGLCsPSyVAVt Myc_N X X -CHUK IKKA O15111 human ER-alpha 2099 P03372 ESR1 human S118 448101 LHPPPQLsPFLQPHG Oest_recep X 2511 -CHUK IKKA O15111 human TRAF4 9618 Q9BUZ4 TRAF4 human S426 3211032 kPGtWRGsLDEsSLG X X -CHUK IKKA O15111 human IkB-alpha 4792 P25963 NFKBIA human S36 448204 RHDsGLDsMkDEEyE X X 5210; 9246 -CHUK IKKA O15111 human NFkB-p100 4791 Q00653 NFKB2 human S872 452185 DsAyGsQsVEQEAEK X X -CHUK IKKA O15111 human RELB 5971 Q01201 RELB human S472 36392502 DFFSGTVsLPGLEPP RelB_transactiv X X -CHUK IKKA O15111 human NFkB-p100 4791 Q00653 NFKB2 human S115 452188 sLVGkQCsELGICAV RHD_DNA_bind X -CHUK IKKA O15111 human DCUN1D5 76863 Q9CXV9 Dcun1d5 mouse S41 9763708 QPPARLIsGEEDFSR X X -CHUK IKKA O15111 human AMBRA1 55626 Q9C0C7 AMBRA1 human S1043 1255792404 CRPEALNsGVEYYWD X X -CHUK IKKA O15111 human DARPP-32 84152 Q9UD71 PPP1R1B human T34 448047 MIrRRRPtPAMLFRL DARPP-32 X X 12438 -CHUK IKKA O15111 human Nik 9020 Q99558 MAP3K14 human S817 27259013 EKNPsKAsQSsRDTL X -CHUK IKKA O15111 human NFkB-p100 4791 Q00653 NFKB2 human S99 452186 EVDLVtHsDPPRAHA RHD_DNA_bind X -CHUK IKKA O15111 human SMRT 9612 Q9Y618 NCOR2 human S2407 454664 AkVSGRPsSRKAKsP X X -CHUK IKKA O15111 human CTNNB1 1499 P35222 CTNNB1 human S33 447487 QQQsyLDsGIHsGAT X 9561; 2009; 4270; 13537; 41334; 60180 -CHUK IKKA O15111 human PUMA 27113 Q9BXH1 BBC3 human S10 18610000 RARQEGSsPEPVEGL PUMA X -CHUK IKKA O15111 human HSC70 15481 P63017 Hspa8 mouse S85 31857927 FDDAVVQsDMkHWPF HSP70 X X -CHUK IKKA O15111 human Nik 9020 Q99558 MAP3K14 human S814 27259014 DDSEKNPsKAsQSsR X -CHUK IKKA O15111 human CBP 1387 Q92793 CREBBP human S1386 478513 FVDsGEMsESFPyRT HAT_KAT11 X X -CHUK IKKA O15111 human TAX1BP1 iso2 8887 Q86VP1-2 TAX1BP1 human S624 468908 RPPVRVPsWGLEDNV X -CHUK IKKA O15111 human NFkB-p100 4791 Q00653 NFKB2 human S123 452189 ELGICAVsVGPKDMT RHD_DNA_bind X -CHUK IKKA O15111 human N-CoR1 20185 Q60974 Ncor1 mouse S2345 2888300 KLINKSNsRKsKsPI X -CHUK IKKA O15111 human CTNNB1 1499 P35222 CTNNB1 human T41 447583 GIHsGATtTAPsLsG X 9561; 9565; 4270; 13537; 41334; 60180 -CHUK IKKA O15111 human NFkB-p65 19697 Q04207 Rela mouse S534 447800 sGDEDFssIADMDFS X X 4887; 3036; 3031; 4886; 3033; 4025; 5733; 13346; 76778; 31553; 80477; 73992; 87672; 83962 -CHUK IKKA O15111 human PIK3R1 18708 P26450 Pik3r1 mouse S690 25018700 EPYNLYSsLKELVLH SH2 X X -CHUK IKKA O15111 human NFkB-p105 4790 P19838 NFKB1 human S932 447771 CDsGVETsFRKLsFt X X 4806; 4808; 41317 -CHUK IKKA O15111 human NFkB-p100 4791 Q00653 NFKB2 human S108 452187 PPRAHAHsLVGkQCs RHD_DNA_bind X -CHUK IKKA O15111 human NFkB-p100 4791 Q00653 NFKB2 human S866 450166 tAEVkEDsAyGsQsV X X 4810 -CDK2 CDK2 P24941 human SNAPIN 23557 O95295 SNAPIN human S133 476022 sGIyPPGsPGk____ X -CDK2 CDK2 P24941 human Rb-like 2 5934 Q08999 RBL2 human S639 449726 DEICIAGsPLtPRRV X -CDK2 CDK2 P24941 human Tau iso8 4137 P10636-8 MAPT human T231 449079 KKVAVVRtPPKsPss X 20473; 71429 -CDK2 CDK2 P24941 human CP110 9738 O43303 CCP110 human S45 35546003 FHGVAILsPLLNIEK CaM_bind X X -CDK2 CDK2 P24941 human MED1 5469 Q15648 MED1 human S1207 3197141 GGSDKLAsPMkPVPG X -CDK2 CDK2 P24941 human BTG1 694 P62324 BTG1 human S159 457381 ELLLGRTsPSKNYNM X -CDK2 CDK2 P24941 human NCL 4691 P19338 NCL human T121 470366 PGkALVAtPGkkGAA X -CDK2 CDK2 P24941 human EEF2 1938 P13639 EEF2 human T435 3180609 rIMGPNytPGkkEDL GTP_EFTU_D2 X -CDK2 CDK2 P24941 human TIF1A 54700 Q9NYV6 RRN3 human S44 470000 LENDFFNsPPRKTVR X -CDK2 CDK2 P24941 human Rb 5925 P06400 RB1 human S780 447978 strPPtLsPIPHIPr Rb_C X 9307; 3590; 8180 -CDK2 CDK2 P24941 human MCM3 4172 P25205 MCM3 human T722 449197 EEMPQVHtPKtADsQ X -CDK2 CDK2 P24941 human ANKRD17 26057 O75179 ANKRD17 human S2401 3177630 SSGVRAPsPAPSSVP X -CDK2 CDK2 P24941 human RBM10 8241 P98175 RBM10 human S89 4033099 RRRRHRHsPtGPPGF X -CDK2 CDK2 P24941 human Chk1 1111 O14757 CHEK1 human S286 465527 tsGGVsEsPsGFskH X -CDK2 CDK2 P24941 human MKL1 57591 Q969V6 MRTFA human T573 31933500 PAPAPLGtPVkQENS X -CDK2 CDK2 P24941 human MyoD 17927 P10085 Myod1 mouse S200 40684505 SGDSDASsPRsNCSD Myf5 X -CDK2 CDK2 P24941 human H1E 3008 P10412 H1-4 human T146 458356 KkATGAAtPkKSAKK X -CDK2 CDK2 P24941 human ELF4 2000 Q99607 ELF4 human T643 463813 SLLTRsPtPAPFsPF X -CDK2 CDK2 P24941 human DYN2 1785 P50570 DNM2 human S764 3191449 LQsAssHsPtPQRRP X -CDK2 CDK2 P24941 human SRC-1 8648 Q15788 NCOA1 human S325 18958505 MTRGTASsPSYRFIL PAS_11 X -CDK2 CDK2 P24941 human GATA3 2625 P23771 GATA3 human T156 33638003 HLFTFPPtPPKDVsP X X -CDK2 CDK2 P24941 human POLL 27343 Q9UGP5 POLL human S177 4781554 PPPtRPVsPPQKAKE X -CDK2 CDK2 P24941 human ELK4 2005 P28324 ELK4 human S387 4317601 LsPVAPLsPARLQGA X X -CDK2 CDK2 P24941 human FOXO1A 2308 Q12778 FOXO1 human S249 471071 EGGkSGksPrRrAAs X X -CDK2 CDK2 P24941 human PPP1CA 5499 P62136 PPP1CA human T320 448686 NPGGRPItPPRNsAK X X 2581 -CDK2 CDK2 P24941 human PTHrP 5744 P12272 PTHLH human T121 449879 YKEQPLKtPGKKKKG Parathyroid X X -CDK2 CDK2 P24941 human CDC6 990 Q99741 CDC6 human S106 450916 DNQLTIksPSkRELA X X -CDK2 CDK2 P24941 human NRF1 4899 Q16656 NRF1 human S102 1868914505 HVFEsNPsIRKRQQT Nrf1_DNA-bind X -CDK2 CDK2 P24941 human PKAR1A 5573 P10644 PRKAR1A human S83 450936 DsREDEIsPPPPNPV X -CDK2 CDK2 P24941 human DRP1 74006 Q8K1M6 Dnm1l mouse S622 454690 PIPIMPAsPQKGHAV X 3455; 4494; 63940 -CDK2 CDK2 P24941 human SRC-1 8648 Q15788 NCOA1 human S22 4711609 DSHKRKGsPCDtLAS X -CDK2 CDK2 P24941 human RAD54L 8438 Q92698 RAD54L human S49 31855101 QIQECFLsPFRkPLS X -CDK2 CDK2 P24941 human SRC-1 8648 Q15788 NCOA1 human S488 18958503 ISLAQFMsPRRQVTS NCOA_u2 X -CDK2 CDK2 P24941 human CDC25A 993 P30304 CDC25A human S283 58934700 PErsQEEsPPGSTKr M-inducer_phosp X X -CDK2 CDK2 P24941 human TTK 7272 P33981 TTK human T468 471488 DyMsCFrtPVVkNDF X -CDK2 CDK2 P24941 human NPM1 18148 Q61937 Npm1 mouse T198 448515 VKKsVRdtPAKNAQK X 3541; 75984 -CDK2 CDK2 P24941 human TBCE 6905 Q15813 TBCE human S495 3197270 DLLLSYEsPKKPGRE Ubiquitin_2 X -CDK2 CDK2 P24941 human PARP10 84875 Q53GL7 PARP10 human T101 12526705 QGLPPGTtPQRLEQH X -CDK2 CDK2 P24941 human p73 7161 O15350 TP73 human T86 449047 AASASPYtPEHAASV X X -CDK2 CDK2 P24941 human CDT1 81620 Q9H211 CDT1 human S31 455585 kLACRtPsPARPALR X -CDK2 CDK2 P24941 human TK 7083 P04183 TK1 human S13 448816 LPtVLPGsPskTRGQ X -CDK2 CDK2 P24941 human FAM168B 130074 A1KXE4 FAM168B human T57 9831677 QTGYTPGtPYKVSCS TCRP1 X -CDK2 CDK2 P24941 human MTA1 9112 Q13330 MTA1 human S522 3195323 RLPEAsQsPLVLkQA MTA_R1 X -CDK2 CDK2 P24941 human SRC-1 8648 Q15788 NCOA1 human T1179 449063 NYGTNPGtPPASTsP DUF1518 X -CDK2 CDK2 P24941 human ER-alpha 2099 P03372 ESR1 human S104 448099 FPPLNsVsPsPLMLL Oest_recep X -CDK2 CDK2 P24941 human FAM122A 116224 Q96E09 PABIR1 human S143 467589 RIDFIPVsPAPsPtR X -CDK2 CDK2 P24941 human CC2D1A 54862 Q6P1N0 CC2D1A human S208 483763 PAstPtysPAPtQPA X -CDK2 CDK2 P24941 human AKIRIN2 55122 Q53H80 AKIRIN2 human S21 485532 DPLLsPAsPKRRRCA X -CDK2 CDK2 P24941 human CTNNB1 84353 Q9WU82 Ctnnb1 rat S45 447488 GATtTAPsLSGkGNP X 9565; 24710; 70034; 19807; 96727; 77605 -CDK2 CDK2 P24941 human B-Myb 17865 P48972 Mybl2 mouse T447 452026 NSLtPKStPVkTLPF X -CDK2 CDK2 P24941 human FOXK2 3607 Q01167 FOXK2 human S373 3193955 sSRsAPAsPNHAGVL X -CDK2 CDK2 P24941 human FBXL11 22992 Q9Y2K7 KDM2A human T550 469788 MKPAPRLtPVRPAAA X -CDK2 CDK2 P24941 human ANKRD17 26057 O75179 ANKRD17 human S2042 3176020 KEHyPVssPssPsPP X -CDK2 CDK2 P24941 human NPAT 4863 Q14207 NPAT human S1100 2286403 VsFPNLDsPNVSSTL NPAT_C X -CDK2 CDK2 P24941 human AML1 iso8 861 Q01196-8 RUNX1 human S276 454399 DTRQIQPsPPWSYDQ X -CDK2 CDK2 P24941 human CENPA 1058 P49450 CENPA human S19 478530 APRRRsPsPtPtPGP Histone X X -CDK2 CDK2 P24941 human SOX2 6657 P48431 SOX2 human S250 6738003 VVksEAsssPPVVtS X 92186 -CDK2 CDK2 P24941 human Snail2 6591 O43623 SNAI2 human S54 31961400 ILSSGAYsPITVWTT X X -CDK2 CDK2 P24941 human IREB2 3658 P48200 IREB2 human S157 2850010 LQkAGkLsPLkVQPK X -CDK2 CDK2 P24941 human RAP140 23272 Q9UK61 TASOR human T819 3952772 HEyELNStPDKKDyE X -CDK2 CDK2 P24941 human SRC-1 8648 Q15788 NCOA1 human T1426 18958502 KPTSGPQtPQAQQKS X X -CDK2 CDK2 P24941 human Rb-like 2 5934 Q08999 RBL2 human S688 449729 RLFVENDsPsDGGtP X -CDK2 CDK2 P24941 human BCLAF1 9774 Q9NYF8 BCLAF1 human T840 455929 EEWDPEytPkSKkyF X -CDK2 CDK2 P24941 human DENR 8562 O43583 DENR human S73 476007 AKLtVENsPKQEAGI X -CDK2 CDK2 P24941 human CDK16 5127 Q00536 CDK16 human S138 2192660 LEkLtLNsPIFDkPL X -CDK2 CDK2 P24941 human Trap150 9967 Q9Y2W1 THRAP3 human T874 460009 EEWDPEytPksKkyy X -CDK2 CDK2 P24941 human C1orf198 84886 Q9H425 C1orf198 human S37 4164748 FTyFSsLsPMARKIM DUF4706 X -CDK2 CDK2 P24941 human MAP2 iso2 25595 P15146-2 Map2 rat S136 448323 ETVNLPPsPPPSPAS X 4541 -CDK2 CDK2 P24941 human RFA2 6118 P15927 RPA2 human S29 448338 QsPGGFGsPAPsQAE X -CDK2 CDK2 P24941 human MCM2 4171 P49736 MCM2 human S41 452312 RtDALtssPGRDLPP X -CDK2 CDK2 P24941 human CDKN2D 1032 P55273 CDKN2D human S76 6046001 VQDTSGTsPVHDAAR Ank_2 X X -CDK2 CDK2 P24941 human SMAD2 4087 Q15796 SMAD2 human S255 448796 ELsPTTLsPVNHsLD X 3104 -CDK2 CDK2 P24941 human POLM 27434 Q9NP87 POLM human S372 28758702 HQHSCCEsPTRLAQQ DNA_pol_B_palm X -CDK2 CDK2 P24941 human MCM4 4173 P33991 MCM4 human T110 450002 PRsGVrGtPVRQRPD X -CDK2 CDK2 P24941 human PR 5241 P06401 PGR human S676 450154 LSQRFTFsPGQDIQL X -CDK2 CDK2 P24941 human EGLN2 112398 Q96KS0 EGLN2 human S130 31088285 EDGGDAPsPsKRPWA X X -CDK2 CDK2 P24941 human E2A 6929 P15923 TCF3 human S245 455906 PMLGGGSsPLPLPPG X -CDK2 CDK2 P24941 human JIP4 9043 O60271 SPAG9 human T586 3175537 NAPtSHVtPsVKKRs X -CDK2 CDK2 P24941 human Rb-like 2 5934 Q08999 RBL2 human T417 449725 KENsPCVtPVSTATH RB_A X -CDK2 CDK2 P24941 human RNF4 6047 P78317 RNF4 human T112 3801490 DVyVTtHtPRNARDE X -CDK2 CDK2 P24941 human RbBP1 5926 P29374 ARID4A human S864 14578923 RKILGQssPEkkIRI X X -CDK2 CDK2 P24941 human NOB1P 28987 Q9ULX3 NOB1 human T121 9831706 SSIQHPEtPLHISGF X -CDK2 CDK2 P24941 human SHP-1 15170 P29351 Ptpn6 mouse S591 454019 DKEKNKGsLKRK___ X X -CDK2 CDK2 P24941 human CCDC6 8030 Q16204 CCDC6 human S244 450707 QPVsAPPsPRDIsME DUF2046 X -CDK2 CDK2 P24941 human DAB1 iso2 Q6XBN7 Dab1 chicken S475 479422 TPAPRQSsPSKSSAS X -CDK2 CDK2 P24941 human LIG1 3978 P18858 LIG1 human S51 468123 GVVsEsDsPVKRPGR X X -CDK2 CDK2 P24941 human DLG1 1739 Q12959 DLG1 human S443 5931300 FLGQtPAsPARysPV PDZ_assoc X X -CDK2 CDK2 P24941 human MCL1 4170 Q07820 MCL1 human S64 479431 IGGSAGAsPPStLtP X X 13297 -CDK2 CDK2 P24941 human snRNP 70 6625 P08621 SNRNP70 human S226 451900 yDERPGPsPLPHRDR X -CDK2 CDK2 P24941 human AML1 iso8 861 Q01196-8 RUNX1 human T300 454403 sPSVHPAtPIsPGRA X -CDK2 CDK2 P24941 human Tau iso8 4137 P10636-8 MAPT human S396 449081 GAEIVyKsPVVsGDt X 9632 -CDK2 CDK2 P24941 human ATRIP 84126 Q8WXE1 ATRIP human S224 485778 APsVsHVsPRKNPSV X X 5161 -CDK2 CDK2 P24941 human CDK7 1022 P50613 CDK7 human T170 448306 GsPNRAytHQVVtRW Pkinase X -CDK2 CDK2 P24941 human PPP1R12C 54776 Q9BZL4 PPP1R12C human S509 9831735 SRIPEPEsPAKPNVP X -CDK2 CDK2 P24941 human SUV39H1 6839 O43463 SUV39H1 human S391 469894 GLAGLPGsPKKRVRI X X -CDK2 CDK2 P24941 human CRMP-1 1400 Q14194 CRMP1 human T509 454314 PVyEVPAtPKyAtPA X -CDK2 CDK2 P24941 human Tau iso8 4137 P10636-8 MAPT human S404 449082 PVVsGDtsPRHLsNV X 35834; 20194; 98523; 91600; 49562 -CDK2 CDK2 P24941 human LRCH3 84859 Q96II8 LRCH3 human S419 3209241 RRIsHEGsPVkPVAI X -CDK2 CDK2 P24941 human TFCP2 7024 Q12800 TFCP2 human S289 7965106 EITYVNNsPsPGFNS X -CDK2 CDK2 P24941 human ID3 3399 Q02535 ID3 human S5 451011 ___MkALsPVRGCyE X X -CDK2 CDK2 P24941 human Rb 5925 P06400 RB1 human T356 447981 DsFEtQRtPRksNLD X 81403; 99158 -CDK2 CDK2 P24941 human SPT5 6829 O00267 SUPT5H human T775 458815 tPMyGsQtPMyGsGs X -CDK2 CDK2 P24941 human SRC-1 8648 Q15788 NCOA1 human S1185 449064 GtPPASTsPFSQLAA DUF1518 X -CDK2 CDK2 P24941 human SCML2 10389 Q9UQR0 SCML2 human T305 3216633 SssVkNItPRKKGPN RBR X X -CDK2 CDK2 P24941 human SRC-1 8648 Q15788 NCOA1 human S1006 18958510 SPTANLPsPFQGMVR X -CDK2 CDK2 P24941 human AR 367 P10275 AR human S96 448416 QQQGEDGsPQAHRRG Androgen_recep X X -CDK2 CDK2 P24941 human PRPF3 9129 O43395 PRPF3 human T167 483115 LsFIsPPtPQPKtPS X -CDK2 CDK2 P24941 human CDK9 1025 P50750 CDK9 human S90 41625400 EICrTkAsPYNRCKG Pkinase X X -CDK2 CDK2 P24941 human Rb-like 1 5933 P28749 RBL1 human S615 36125980 HLPLMPMsPLMHPRV X -CDK2 CDK2 P24941 human ELF4 2000 Q99607 ELF4 human S648 463814 sPtPAPFsPFNPTSL X -CDK2 CDK2 P24941 human TTK 7272 P33981 TTK human T453 471487 DPkSICktPsSNtLD X -CDK2 CDK2 P24941 human C17orf49 124944 Q8IXM2 C17orf49 human S96 478219 GIPLPAEsPKKGPKK X -CDK2 CDK2 P24941 human TOPBP1 11073 Q92547 TOPBP1 human T848 3208170 DALAALEtPGRPsQQ X -CDK2 CDK2 P24941 human CTNNB1 84353 Q9WU82 Ctnnb1 rat S33 447487 QQQSYLDsGIHsGAT X 9561; 2009; 4270; 13537; 41334; 60180 -CDK2 CDK2 P24941 human hnRNP K 3190 P61978 HNRNPK human S284 448185 rrDyDDMsPrrGPPP X -CDK2 CDK2 P24941 human GRK2 156 P25098 GRK2 human S670 447725 KMKNKPRsPVVELsk X -CDK2 CDK2 P24941 human RPS27 6232 P42677 RPS27 human S27 4272667 KKkRLVQsPNsyFMD X -CDK2 CDK2 P24941 human FZR1 51343 Q9UM11 FZR1 human S163 4661904 kSQKLLRsPRKPTRK X -CDK2 CDK2 P24941 human Rb 5925 P06400 RB1 human T826 447984 LPtPtkMtPRsRILV Rb_C X -CDK2 CDK2 P24941 human NuMA-1 4926 Q14980 NUMA1 human T1776 459920 sLEsLyFtPIPARsQ X -CDK2 CDK2 P24941 human RAD54L 8438 Q92698 RAD54L human T31 3801660 DWQPGLVtPRKRKss X -CDK2 CDK2 P24941 human TFCP2 7024 Q12800 TFCP2 human S309 7965105 SLGEGNGsPNHQPEP X X -CDK2 CDK2 P24941 human UNG 7374 P13051 UNG human S23 2018600 ARKRHAPsPEPAVQG X -CDK2 CDK2 P24941 human MCM4 17217 P49717 Mcm4 mouse T19 448634 SSRRGRVtPtQsLRs X -CDK2 CDK2 P24941 human GATA3 14462 P23772 Gata3 mouse T155 33638003 HLFTFPPtPPKDVsP X -CDK2 CDK2 P24941 human hnRNP D0 3184 Q14103 HNRNPD human T193 466981 VGGLsPDtPEEkIRE RRM_1 X -CDK2 CDK2 P24941 human RRM2 6241 P31350 RRM2 human T33 3189775 sLVdkENtPPALsGt X 74736 -CDK2 CDK2 P24941 human STMN1 3925 P16949 STMN1 human S25 448555 QAFELILsPrskEsV Stathmin X -CDK2 CDK2 P24941 human RbBP1 5926 P29374 ARID4A human S1007 17743401 QHNFSVAsPLTLSQD X X -CDK2 CDK2 P24941 human Ku70 2547 P12956 XRCC6 human T455 469188 FTEkIMAtPEQVGkM Ku X -CDK2 CDK2 P24941 human SRC-1 8648 Q15788 NCOA1 human S1033 449119 tPPrGAFsPGMGMQP X -CDK2 CDK2 P24941 human Rb-like 2 5934 Q08999 RBL2 human S662 449728 GLGRsItsPttLyDR X -CDK2 CDK2 P24941 human GR 24413 P06536 Nr3c1 rat S224 447967 DLEFSAGsPSKDTNE GCR X -CDK2 CDK2 P24941 human H1F1 3024 Q02539 H1-1 human T152 13357125 ASKKSVKtPKKAKKP X -CDK2 CDK2 P24941 human CP110 9738 O43303 CCP110 human S170 22351338 RDsEGFNsPKQCDSS X X -CDK2 CDK2 P24941 human POLL 27343 Q9UGP5 POLL human T553 5312301 GPGRVLPtPTEKDVF DNA_pol_B_thumb X -CDK2 CDK2 P24941 human NUP98 4928 P52948 NUP98 human S612 470432 LNNsNLFsPVNRDsE X -CDK2 CDK2 P24941 human NPAT 4863 Q14207 NPAT human S779 2286402 ILSsPTKsPTKNAEL NPAT_C X -CDK2 CDK2 P24941 human E2A 6929 P15923 TCF3 human S139 455905 LNsPGPLsPsGMKGT X -CDK2 CDK2 P24941 human Kv-beta2 8514 Q13303 KCNAB2 human S31 3996100 IystrYGsPKRQLQF X -CDK2 CDK2 P24941 human SCML2 10389 Q9UQR0 SCML2 human S511 449227 VPyVVPLsPKLPKTk X X -CDK2 CDK2 P24941 human RPL11 6135 P62913 RPL11 human T47 4274932 LEQLtGQtPVFskAR Ribosomal_L5 X -CDK2 CDK2 P24941 human TRF2 21750 O35144 Terf2 mouse S367 452842 ANLAsPssPAHKHKR X -CDK2 CDK2 P24941 human Cortactin 2017 Q14247 CTTN human S405 447700 KtQtPPVsPAPQPtE X -CDK2 CDK2 P24941 human Rb-like 2 5934 Q08999 RBL2 human S1068 449740 HKNEtMLsPREKIFY X -CDK2 CDK2 P24941 human Akt1 207 P31749 AKT1 human S477 8086735 PQFsysAsGtA____ X X -CDK2 CDK2 P24941 human DDX48 9775 P38919 EIF4A3 human T163 3190132 GQHVVAGtPGRVFDM DEAD X X -CDK2 CDK2 P24941 human CP110 9738 O43303 CCP110 human T194 2024013 FPKTSSAtPQETLIS X X -CDK2 CDK2 P24941 human POLH 5429 Q9Y253 POLH human S687 4931282 QGkRNPksPLACTNk X X -CDK2 CDK2 P24941 human NPM1 4869 P06748 NPM1 human T234 449024 sFkkQEKtPKtPkGP X -CDK2 CDK2 P24941 human CDX2 1045 Q99626 CDX2 human S283 456208 RsVPEPLsPVSSLQA X X -CDK2 CDK2 P24941 human ETAA16 54465 Q9NY74 ETAA1 human S95 1869465805 SLSSSFSsPNDPDGQ ETAA1 X X -CDK2 CDK2 P24941 human PR 5241 P06401 PGR human S400 449842 GAEAsARsPRSYLVA Prog_receptor X -CDK2 CDK2 P24941 human FOXO1A 2308 Q12778 FOXO1 human S298 471972 QFskWPAsPGsHsND X -CDK2 CDK2 P24941 human UBE2O 63893 Q9C0C9 UBE2O human S836 484765 VEQLLTGsPtsPtVE X -CDK2 CDK2 P24941 human SMAD2 4087 Q15796 SMAD2 human S250 448795 TGsPAELsPTTLsPV X 3104 -CDK2 CDK2 P24941 human MDM2 17246 P23804 Mdm2 mouse T216 450150 SSSESTEtPSHQDLD X -CDK2 CDK2 P24941 human EEF2 1938 P13639 EEF2 human S595 27620701 NVLCLsksPNkHNRL X X -CDK2 CDK2 P24941 human RbBP1 5926 P29374 ARID4A human S1140 14578926 KPQKLARsPARIsPH X -CDK2 CDK2 P24941 human SFRS9 8683 Q13242 SRSF9 human S216 465904 rGsPHyFsPFRPy__ X -CDK2 CDK2 P24941 human Caldesmon 800 Q05682 CALD1 human T730 448467 ssPtAAGtPNkEtAG Caldesmon X -CDK2 CDK2 P24941 human LIG3 3980 P49916 LIG3 human T191 2883701 LSSKAAGtPKKKAVV X -CDK2 CDK2 P24941 human CDK7 1022 P50613 CDK7 human S164 450041 GLAksFGsPNRAytH Pkinase X -CDK2 CDK2 P24941 human RbBP1 5926 P29374 ARID4A human T1124 17772902 LDNSSKCtPVKHLNV X -CDK2 CDK2 P24941 human SOX2 20674 P48432 Sox2 mouse S39 18913847 TGGNQkNsPDRVKRP X -CDK2 CDK2 P24941 human PLZF 7704 Q05516 ZBTB16 human T282 2134716 RGKEGPGtPTRSSVI X X -CDK2 CDK2 P24941 human SRC-1 8648 Q15788 NCOA1 human T1271 18958508 QSSLLQQtPPASGYQ X -CDK2 CDK2 P24941 human SRC-1 8648 Q15788 NCOA1 human S395 449116 PsVNPsIsPAHGVAR X -CDK2 CDK2 P24941 human ORC2 4999 Q13416 ORC2 human T226 7320974 sAPVGKEtPsKRMKR X X -CDK2 CDK2 P24941 human Rb 5925 P06400 RB1 human T252 449821 PINGsPRtPRRGQNR X X -CDK2 CDK2 P24941 human STMN1 3925 P16949 STMN1 human S38 448556 sVPEFPLsPPkKkDL Stathmin X 3426; 4191 -CDK2 CDK2 P24941 human SPT6 6830 Q7KZ85 SUPT6H human T1523 3203790 QDPVPGItPSsssRt X -CDK2 CDK2 P24941 human MAP2 25595 P15146 Map2 rat S136 448323 ETVNLPPsPPPsPAS X 4541 -CDK2 CDK2 P24941 human FOXC1 2296 Q12948 FOXC1 human T68 3950892 ArAYGPYtPQPQPKD X -CDK2 CDK2 P24941 human MTHFD1L 25902 Q6UB35 MTHFD1L human S357 9831636 CLkLQPLsPVPSDIE X -CDK2 CDK2 P24941 human Rb-like 2 5934 Q08999 RBL2 human T642 449727 CIAGsPLtPRRVtEV X -CDK2 CDK2 P24941 human MCL1 4170 Q07820 MCL1 human S121 1172400 PAADAIMsPEEELDG X -CDK2 CDK2 P24941 human SETDB1 9869 Q15047 SETDB1 human S1066 3196787 RNYGYNPsPVkPEGL SET X -CDK2 CDK2 P24941 human B-Myb 4605 P10244 MYBL2 human T518 450111 SMDNtPHtPtPFkNA Cmyb_C X -CDK2 CDK2 P24941 human LARP 23367 Q6PKG0 LARP1 human T649 468112 KILIVtQtPHyMRRH X -CDK2 CDK2 P24941 human B-Myb 4605 P10244 MYBL2 human S577 450115 RKPGLRRsPIKKVRk Cmyb_C X -CDK2 CDK2 P24941 human PR 5241 P06401 PGR human S190 447986 kVLPRGLsPARQLLL Prog_receptor X 3171 -CDK2 CDK2 P24941 human TFCP2 7024 Q12800 TFCP2 human S291 7965107 TYVNNsPsPGFNSSH X -CDK2 CDK2 P24941 human ACF7 23499 Q9UPN3 MACF1 human T7213 9831680 EGAsQGMtPFRsRGR X -CDK2 CDK2 P24941 human Lamin B2 84823 Q03252 LMNB2 human S37 455588 GGPAtPLsPtRLsRL X -CDK2 CDK2 P24941 human LIG3 3980 P49916 LIG3 human S913 2883700 EkLAtKssPVKVGEK X -CDK2 CDK2 P24941 human BARD1 580 Q99728 BARD1 human S148 455770 NSIkMWFsPRSkKVR X -CDK2 CDK2 P24941 human LARP 23367 Q6PKG0 LARP1 human S774 453830 LPttVPEsPNyRNtR X -CDK2 CDK2 P24941 human MCM2 4171 P49736 MCM2 human S40 452311 RRtDALtssPGRDLP X -CDK2 CDK2 P24941 human EVI1 2122 Q03112 MECOM human S624 4702996 KMFKDkVsPLQNLAS X -CDK2 CDK2 P24941 human ETAA16 54465 Q9NY74 ETAA1 human S111 1869465806 DIFWDQNsPLTKQLG ETAA1 X X -CDK2 CDK2 P24941 human PXR 8856 O75469 NR1I2 human T135 30259804 KKSERtGtQPLGVQG X -CDK2 CDK2 P24941 human FZR1 51343 Q9UM11 FZR1 human T121 3827860 DRRLQPstPEKkGLF X -CDK2 CDK2 P24941 human PAICS 10606 P22234 PAICS human S27 483584 EVyELLDsPGkVLLQ SAICAR_synt X -CDK2 CDK2 P24941 human NBS1 27354 Q9R207 Nbn mouse S433 483547 KtPsYQLsPMKFPVA X -CDK2 CDK2 P24941 human RANGAP1 19387 P46061 Rangap1 mouse T411 2906105 GSGEEPAtPSRKILD RanGAP1_C X -CDK2 CDK2 P24941 human SF3B1 23451 O75533 SF3B1 human T313 449360 HGsGWAEtPRtDrGG X 25009 -CDK2 CDK2 P24941 human NUDE1 iso1 54820 Q9NXR1-1 NDE1 human T228 449452 GPsssLNtPGsFRRG NUDE_C X -CDK2 CDK2 P24941 human PMS2 18861 P54279 Pms2 mouse T337 1881225900 ECVDINVtPDKRQIL X -CDK2 CDK2 P24941 human CDC6 990 Q99741 CDC6 human S74 450915 tPHLPPCsPPKQGKK X X -CDK2 CDK2 P24941 human SMAD2 4087 Q15796 SMAD2 human S245 448794 NQsMDTGsPAELsPT X 3104 -CDK2 CDK2 P24941 human UNG 7374 P13051 UNG human S64 2018601 EPGtPPssPLsAEQL X -CDK2 CDK2 P24941 human NUP133 55746 Q8WUM0 NUP133 human S50 483775 VssPVLFsPVGrRss X -CDK2 CDK2 P24941 human Rb 5925 P06400 RB1 human S567 450021 SLAWLSDsPLFDLIk RB_A X -CDK2 CDK2 P24941 human RAD18 56852 Q9NS91 RAD18 human S99 449217 LLQFALEsPAksPAs X -CDK2 CDK2 P24941 human MCM7 4176 P33993 MCM7 human S365 10027300 LVGGVDQsPRGMKIR MCM X -CDK2 CDK2 P24941 human DNMT1 1786 P26358 DNMT1 human S154 476108 AkPEPsPsPRITRkS X -CDK2 CDK2 P24941 human LIG1 3978 P18858 LIG1 human S76 449246 EEEDEALsPAkGQKP X X -CDK2 CDK2 P24941 human BRCA1 672 P38398 BRCA1 human S114 18007298 FAkKENNsPEHLkDE X -CDK2 CDK2 P24941 human Rb 5925 P06400 RB1 human S249 447975 AVIPINGsPRtPRRG X X -CDK2 CDK2 P24941 human FOXK2 3607 Q01167 FOXK2 human S428 3193961 FAQsAPGsPLssQPV X -CDK2 CDK2 P24941 human NRIF3 23421 Q13352 ITGB3BP human S33 455815 KKsVITysPTTGTCQ CENP-R X -CDK2 CDK2 P24941 human Kv-beta2 29738 P62483 Kcnab2 rat S31 3996100 IyStRYGsPKRQLQF X X -CDK2 CDK2 P24941 human Chk1 1111 O14757 CHEK1 human S301 465528 IQsNLDFsPVNsAss X -CDK2 CDK2 P24941 human CCNO 10309 P22674 CCNO human S81 7445148 PSAARGGsPLPGPAQ X -CDK2 CDK2 P24941 human CTTNBP2NL 55917 Q9P2B4 CTTNBP2NL human S563 453212 ssPLsPLsPGIKsPt X -CDK2 CDK2 P24941 human HMGA1 3159 P17096 HMGA1 human S36 455950 PRkQPPVsPGtALVG X -CDK2 CDK2 P24941 human RRM2 6241 P31350 RRM2 human S20 457399 DPQQLQLsPLkGLsL X -CDK2 CDK2 P24941 human NPM1 4869 P06748 NPM1 human T199 448515 VkKsIrDtPAkNAQK X 3541; 75984 -CDK2 CDK2 P24941 human UNG 7374 P13051 UNG human T60 452622 AGQEEPGtPPssPLs X -CDK2 CDK2 P24941 human LIG3 3980 P49916 LIG3 human S210 468127 TttGQVtsPVkGAsF X X -CDK2 CDK2 P24941 human BRCA1 672 P38398 BRCA1 human S1497 448730 EPGVERssPsKCPsL X X -CDK2 CDK2 P24941 human Rb-like 2 5934 Q08999 RBL2 human T694 449730 DsPsDGGtPGRMPPQ X -CDK2 CDK2 P24941 human Rb 5925 P06400 RB1 human S612 447977 MyLsPVRsPKKKGsT X -CDK2 CDK2 P24941 human NUCKS 64710 Q9H1E3 NUCKS1 human S181 452956 LkAtVtPsPVkGkGk X -CDK2 CDK2 P24941 human p63 8626 Q9H3D4 TP63 human T491 4668106 PQQRNALtPTTIPDG X X -CDK2 CDK2 P24941 human C/EBP-beta 24253 P21272 Cebpb rat S64 456166 HERAIDFsPYLEPLA X -CDK2 CDK2 P24941 human Rb-like 2 5934 Q08999 RBL2 human S413 449724 VRYIKENsPCVtPVS X -CDK2 CDK2 P24941 human MDC1 9656 Q14676 MDC1 human S1068 486515 LAPPPLLsPLLPSIk X -CDK2 CDK2 P24941 human PHF8 23133 Q9UPP1 PHF8 human S880 3216126 NsDDAPWsPKARVtP X X -CDK2 CDK2 P24941 human SKP2 6502 Q13309 SKP2 human S64 457412 sNLGHPEsPPRkRLk X X 14865 -CDK2 CDK2 P24941 human MASTL 84930 Q96GX5 MASTL human T194 3209097 NMMDILTtPSMAkPR Pkinase X -CDK2 CDK2 P24941 human SRC-1 8648 Q15788 NCOA1 human T979 18958506 RFPPQQAtPPLIMEE X -CDK2 CDK2 P24941 human AML1 iso8 861 Q01196-8 RUNX1 human S303 454401 VHPAtPIsPGRASGM X -CDK2 CDK2 P24941 human CP110 9738 O43303 CCP110 human S372 9318022 PsPEPsMsPKMHRRR X X -CDK2 CDK2 P24941 human SOX2 6657 P48431 SOX2 human S249 6738004 SVVksEAsssPPVVt X -CDK2 CDK2 P24941 human MCM4 17217 P49717 Mcm4 mouse S53 448667 ELLPMPTsPGADLQS X -CDK2 CDK2 P24941 human p27Kip1 1027 P46527 CDKN1B human T187 447875 NAGsVEQtPKKPGLR X X -CDK2 CDK2 P24941 human Rb-like 1 5933 P28749 RBL1 human S640 451296 RRDMQPLsPIsVHER X -CDK2 CDK2 P24941 human TNRC15 26058 Q6Y7W6 GIGYF2 human S593 3203298 MWGRVPFsPGPAPPP X -CDK2 CDK2 P24941 human SIRT2 iso2 22933 Q8IXJ6-2 SIRT2 human S331 482809 PNPSTSAsPKKSPPP X -CDK2 CDK2 P24941 human SRC-1 8648 Q15788 NCOA1 human S569 449118 RQMssQNsPSRLNIQ NCOA_u2 X -CDK2 CDK2 P24941 human PXR 8856 O75469 NR1I2 human S114 30259801 MKkEMIMsDEAVEER X -CDK2 CDK2 P24941 human RAD9A 5883 Q99638 RAD9A human S328 449812 VLPsIsLsPGPQPPK X X -CDK2 CDK2 P24941 human PELP1 27043 Q8IZL8 PELP1 human S477 470174 ADALKLRsPRGsPDG NUC202 X -CDK2 CDK2 P24941 human MCL1 4170 Q07820 MCL1 human T92 4825134 EVPDVTAtPARLLFF X -CDK2 CDK2 P24941 human BARD1 580 Q99728 BARD1 human S251 455769 sQPSVISsPQINGEI X -CDK2 CDK2 P24941 human CDT1 81620 Q9H211 CDT1 human T29 455584 PPkLACRtPsPARPA X -CDK2 CDK2 P24941 human Tau iso8 4137 P10636-8 MAPT human S202 447928 sGyssPGsPGtPGsR X 39357; 30505 -CDK2 CDK2 P24941 human AARSL 57505 Q5JTZ9 AARS2 human T673 9831755 VTTQTPLtPEQLRAV X -CDK2 CDK2 P24941 human Rb-like 2 5934 Q08999 RBL2 human T1097 449742 sMIRTGEtPTKKRGI X -CDK2 CDK2 P24941 human MLH1 17350 Q9JK91 Mlh1 mouse T495 1881245400 NASGKEMtAACYPRR X -CDK2 CDK2 P24941 human DENR 8562 O43583 DENR human T69 476008 PNEFAKLtVENsPKQ X -CDK2 CDK2 P24941 human RRM1 6240 P23921 RRM1 human S559 31890671 PyEtyEGsPVSkGIL Ribonuc_red_lgC X X -CDK2 CDK2 P24941 human ZNF261 9203 Q14202 ZMYM3 human T826 3801541 PPPPPPAtPRKNKAA X -CDK2 CDK2 P24941 human ATF-2 1386 P15336 ATF2 human T116 3180684 LDLsPLAtPIIRsKI X -CDK2 CDK2 P24941 human RALY 22913 Q9UKM9 RALY human S135 465875 FDYrGRLsPVPVPrA X -CDK2 CDK2 P24941 human RNF4 6047 P78317 RNF4 human T26 41192600 RTREATStPEISLEA X -CDK2 CDK2 P24941 human NRF1 4899 Q16656 NRF1 human S136 23255800 QAIVLCIsPskPNPV Nrf1_DNA-bind X -CDK2 CDK2 P24941 human NRIF3 23421 Q13352 ITGB3BP human S46 455816 CQMSLFAsPTSSEEQ CENP-R X -CDK2 CDK2 P24941 human p21Cip1 1026 P38936 CDKN1A human S130 455618 sGEQAEGsPGGPGDs X X -CDK2 CDK2 P24941 human CTNNB1 84353 Q9WU82 Ctnnb1 rat S37 447582 YLDsGIHsGATtTAP X 9561; 2009; 4270; 13537; 41334; 60180 -CDK2 CDK2 P24941 human ING5 84289 Q8WYH8 ING5 human T152 23115779 RRtsEEDtPkkKKHK X X -CDK2 CDK2 P24941 human BIN1 274 O00499 BIN1 human T348 7532308 VPPPPKHtPSKEVKQ X -CDK2 CDK2 P24941 human PTP-PEST 5782 Q05209 PTPN12 human S19 18014400 QRVQAMKsPDHNGED X X -CDK2 CDK2 P24941 human TRF2 7014 Q15554 TERF2 human S365 452842 PTQALPAsPALKNKR X X -CDK2 CDK2 P24941 human RECQL4 9401 O94761 RECQL4 human S251 25173044 EVSIRVGsPQPSSSG X X -CDK2 CDK2 P24941 human Diaphanous-3 81624 Q9NSV4 DIAPH3 human T19 9831662 AQGSAAGtPYPsSAs X -CDK2 CDK2 P24941 human ER-alpha 2099 P03372 ESR1 human S118 448101 LHPPPQLsPFLQPHG Oest_recep X 2511 -CDK2 CDK2 P24941 human IMPDH2 3615 P12268 IMPDH2 human S122 3180540 ITDPVVLsPkDRVRD IMPDH; CBS X -CDK2 CDK2 P24941 human SF3B1 23451 O75533 SF3B1 human T211 468708 ADQtPGAtPkkLssW X -CDK2 CDK2 P24941 human Afadin 4301 P55196 AFDN human T1352 9831600 TPAAIPAtPVAVSQP X -CDK2 CDK2 P24941 human NCAPH 23397 Q15003 NCAPH human T49 459684 APLNIPGtPVLEDFP Cnd2 X -CDK2 CDK2 P24941 human SMAD3 4088 P84022 SMAD3 human S208 451179 DAGsPNLsPNPMsPA X -CDK2 CDK2 P24941 human C/EBP-beta 24253 P21272 Cebpb rat T189 447878 SSSsPPGtPSPADAK X 3084 -CDK2 CDK2 P24941 human TORC2 200186 Q53ET0 CRTC2 human S433 454653 HHRRVPLsPLsLLAG X -CDK2 CDK2 P24941 human hnRNP H1 3187 P31943 HNRNPH1 human S104 455395 LkHtGPNsPDtANDG X -CDK2 CDK2 P24941 human ER-alpha 2099 P03372 ESR1 human S106 448100 PLNsVsPsPLMLLHP Oest_recep X -CDK2 CDK2 P24941 human CtIP 5932 Q99708 RBBP8 human T315 4766297 FsDSTSktPPQEELP X -CDK2 CDK2 P24941 human TERF2IP 54386 Q9NYB0 TERF2IP human S203 454348 LLGDAPVsPssQkLK X -CDK2 CDK2 P24941 human PXR 8856 O75469 NR1I2 human S200 30259805 REEAAKWsQVRKDLC X -CDK2 CDK2 P24941 human MCM3 17215 P25206 Mcm3 mouse S611 2840506 SSDTARTsPVTARTL MCM_lid X -CDK2 CDK2 P24941 human HIRA 7290 P54198 HIRA human T555 448427 LsPsVLttPsKIEPM X X -CDK2 CDK2 P24941 human SRC-1 8648 Q15788 NCOA1 human T789 18958504 DPCNTNPtPMTKPTP X -CDK2 CDK2 P24941 human RAMP 51514 Q9NZJ0 DTL human T464 4717290 DLPLPsNtPTFSIKt X -CDK2 CDK2 P24941 human CDC25C 995 P30307 CDC25C human S214 448417 sRsGLyRsPsMPENL M-inducer_phosp X -CDK2 CDK2 P24941 human CP110 9738 O43303 CCP110 human S516 23095734 ASSQCIAsPNFGTVS X X -CDK2 CDK2 P24941 human SF3B1 23451 O75533 SF3B1 human T248 455542 GsEtPGAtPGsKIWD X -CDK2 CDK2 P24941 human TR-beta1 iso2 21834 P37242-2 Thrb mouse S101 1877436600 KPFPQVQsPPHSQKK X X -CDK2 CDK2 P24941 human BARD1 580 Q99728 BARD1 human T299 455768 KSRNEVVtPEKVCkN X -CDK2 CDK2 P24941 human ER-alpha 2099 P03372 ESR1 human S294 451560 RAANLWPsPLMIkRS X X -CDK2 CDK2 P24941 human RPL12 6136 P30050 RPL12 human S38 468652 kIGPLGLsPkkVGDD Ribosomal_L11_N X X -CDK2 CDK2 P24941 human FZR1 51343 Q9UM11 FZR1 human S40 3215931 PAssPVssPsKHGDR X -CDK2 CDK2 P24941 human UBE2A 7319 P49459 UBE2A human S120 448007 LDEPNPNsPANSQAA UQ_con X X -CDK2 CDK2 P24941 human FOXM1 iso2 2305 Q08050-2 FOXM1 human T596 451437 ETLPISStPSKSVLP X -CDK2 CDK2 P24941 human Rb-like 2 5934 Q08999 RBL2 human S1080 449741 IFYYFsNsPsKRLRE X -CDK2 CDK2 P24941 human vinexin iso10 10174 O60504_VAR_055019 SORBS3 human S563 452555 tDLGGQtsPRRTGFS X -CDK2 CDK2 P24941 human SF3B1 23451 O75533 SF3B1 human T244 455541 GRAkGsEtPGAtPGs X -CDK2 CDK2 P24941 human SRC-1 8648 Q15788 NCOA1 human S1250 18958511 ANFAPSLsPGSSMVP DUF1518 X -CDK2 CDK2 P24941 human WRN 7486 Q14191 WRN human S1133 10940893 KksIMVQsPEKAYSS X X -CDK2 CDK2 P24941 human PELP1 27043 Q8IZL8 PELP1 human S991 15334104 PALPPPEsPPKVQPE X X -CDK2 CDK2 P24941 human OLIG2 50913 Q9EQW6 Olig2 mouse S14 18357901 LVSsRPssPEPDDLF X -CDK2 CDK2 P24941 human TICRR 90381 Q7Z2Z1 TICRR human S1001 4752817 DIGVVEEsPEKGDEI Treslin_N X X -CDK2 CDK2 P24941 human DDX3 1654 O00571 DDX3X human T204 457783 LTRyTRPtPVQkHAI DEAD X -CDK2 CDK2 P24941 human QTRT1 81890 Q9BXR0 QTRT1 human S139 9831771 DGNETLLsPEKSVQI TGT X -CDK2 CDK2 P24941 human LIG1 3978 P18858 LIG1 human S91 2999200 ALDCSQVsPPRPAts X X -CDK2 CDK2 P24941 human TSPYL2 64061 Q9H2G4 TSPYL2 human T340 12559513 GRLVSHstPIRWHRG NAP X -CDK2 CDK2 P24941 human CtIP 5932 Q99708 RBBP8 human T847 7113805 FRYIPPNtPENFWEV SAE2 X X -CDK2 CDK2 P24941 human MED1 5469 Q15648 MED1 human T1215 3197162 PMkPVPGtPPsSKAK X -CDK2 CDK2 P24941 human CP110 9738 O43303 CCP110 human S366 9314148 GSYAkLPsPEPsMsP X X -CDK2 CDK2 P24941 human PLZF 7704 Q05516 ZBTB16 human S197 2134715 SFGLSAMsPTKAAVD X X -CDK2 CDK2 P24941 human SF3B1 23451 O75533 SF3B1 human T142 455974 PFADGGktPDPkMNA X -CDK2 CDK2 P24941 human CROCC iso2 9696 Q5TZA2-2 CROCC human S763 14159744 APRPVPGsPARDAPA X X -CDK2 CDK2 P24941 human Snail2 6591 O43623 SNAI2 human S104 25603909 KDHsGSEsPISDEEE X X -CDK2 CDK2 P24941 human EZH2 14056 Q61188 Ezh2 mouse T416 10417699 EANsRCQtPIKMKPN X -CDK2 CDK2 P24941 human eIF4G 1981 Q04637 EIF4G1 human T647 3194303 VLDKANktPLRPLDP X -CDK2 CDK2 P24941 human TUBG2 27175 Q9NRH3 TUBG2 human S80 23070049 VIHSILNsPYAkLYN Tubulin X -CDK2 CDK2 P24941 human CP110 9738 O43303 CCP110 human S400 4744475 PINACELsPKGKEQA X X -CDK2 CDK2 P24941 human USP37 57695 Q86T82 USP37 human S628 469345 MVNsCItsPStPSKK UCH X X -CDK2 CDK2 P24941 human SMAD3 4088 P84022 SMAD3 human S204 451178 NHSMDAGsPNLsPNP X -CDK2 CDK2 P24941 human MCM2 4171 P49736 MCM2 human S13 473057 EsFtMAssPAQRRRG X -CDK2 CDK2 P24941 human DLG1 1739 Q12959 DLG1 human S158 2024309 FVsHsHIsPIKPTEA MAGUK_N_PEST X X -CDK2 CDK2 P24941 human NCL 4691 P19338 NCL human T76 483581 tkkVAVAtPAkkAAV X -CDK2 CDK2 P24941 human ANKLE2 23141 Q86XL3 ANKLE2 human S528 478556 RAFAGPLsPAkAEDF X -CDK2 CDK2 P24941 human WHSC2 7469 Q9H3P2 NELFA human T157 452967 TTLAGPLtPPVkHFQ X -CDK2 CDK2 P24941 human LIG1 3978 P18858 LIG1 human T233 468125 kTLssFFtPRKPAVk X -CDK2 CDK2 P24941 human FOXP3 20371 Q99JB6 Foxp3 mouse T175 29672100 CTFPRSGtPRKDSNL X -CDK2 CDK2 P24941 human ZHX1 11244 Q9UKY1 ZHX1 human T568 9831792 WNPFPDFtPQKFKEK X -CDK2 CDK2 P24941 human CIZ1 68379 Q8VEH2 Ciz1 mouse T293 15418576 TAPKQTQtPDRLPEP X -CDK2 CDK2 P24941 human RbBP1 5926 P29374 ARID4A human S1145 14578929 ARsPARIsPHIKDGE X -CDK2 CDK2 P24941 human RFA2 6118 P15927 RPA2 human S33 448339 GFGsPAPsQAEkkSR X 10148 -CDK2 CDK2 P24941 human MCM4 17217 P49717 Mcm4 mouse S3 448666 _____MssPAstPsR X X -CDK2 CDK2 P24941 human MDC1 9656 Q14676 MDC1 human T1630 471610 tstDQPVtPKLTSRA X -CDK2 CDK2 P24941 human POLL 27343 Q9UGP5 POLL human S230 5312300 LEGDCEPsPAPAVLD X -CDK2 CDK2 P24941 human NPM1 4869 P06748 NPM1 human S70 459898 EAMNyEGsPIkVtLA Nucleoplasmin X -CDK2 CDK2 P24941 human ORC2 4999 Q13416 ORC2 human T116 3195386 LAsELAKtPQKSVsF X X -CDK2 CDK2 P24941 human MCM4 4173 P33991 MCM4 human S32 450001 RsEDARssPsQRRRG X -CDK2 CDK2 P24941 human NPAT 4863 Q14207 NPAT human T1270 2286400 sDLPVPRtPGSGAGE NPAT_C X X -CDK2 CDK2 P24941 human MRPS18B 28973 Q9Y676 MRPS18B human S49 4269907 sLSSVPIsPYkDEPW X -CDK2 CDK2 P24941 human RFA2 6118 P15927 RPA2 human S23 448337 GAGGYtQsPGGFGsP X -CDK2 CDK2 P24941 human MDC1 9656 Q14676 MDC1 human T341 3196397 EEERIPAtPVVIPMK X -CDK2 CDK2 P24941 human CP110 9738 O43303 CCP110 human T566 35546004 NTRQQMDtPMVSCGN X X -CDK2 CDK2 P24941 human BRCA2 675 P51587 BRCA2 human T77 15418117 syNQLAstPIIFKEQ X -CDK2 CDK2 P24941 human ORC1L 4998 Q13415 ORC1 human S273 7320969 VAFsEITsPsKRSQP X -CDK2 CDK2 P24941 human BLM 641 P54132 BLM human S175 23086547 sFVtPPQsHFVRVSt BLM_N X -CDK2 CDK2 P24941 human DRP1 10059 O00429 DNM1L human S616 454690 PIPIMPAsPQKGHAV X 3455; 4494; 63940 -CDK2 CDK2 P24941 human Rb-like 1 5933 P28749 RBL1 human S650 455534 sVHERySsPtAGSAk X -CDK2 CDK2 P24941 human UNG 7374 P13051 UNG human S12 3180591 ktLysFFsPsPARKR X -CDK2 CDK2 P24941 human RECQL4 9401 O94761 RECQL4 human S89 25173042 LNRAATKsPQStPGR Drc1-Sld2 X X -CDK2 CDK2 P24941 human requiem 5977 Q92785 DPF2 human T176 3208425 DEDyEEDtPkRRGKG X -CDK2 CDK2 P24941 human ADD3 120 Q9UEY8 ADD3 human S423 2050001 EDDtVPLsPLkyMAQ X -CDK2 CDK2 P24941 human INCA1 388324 Q0VD86 INCA1 human S191 12524603 GRAQLLWsPWSPLDQ X -CDK2 CDK2 P24941 human CDC7 8317 O00311 CDC7 human T376 2864203 QVAPRAGtPGFRAPE Pkinase X -CDK2 CDK2 P24941 human CDK2 1017 P24941 CDK2 human T160 447739 GVPVRtytHEVVtLW Pkinase X 2561 -CDK2 CDK2 P24941 human HuR 1994 Q15717 ELAVL1 human S202 3197192 LLsQLyHsPArrFGG X -CDK2 CDK2 P24941 human CCNE1 898 P24864 CCNE1 human T395 447676 PLPSGLLtPPQsGKK X X -CDK2 CDK2 P24941 human Rb 5925 P06400 RB1 human T821 447983 kIsEGLPtPtkMtPR Rb_C X X 31433 -CDK2 CDK2 P24941 human CDC6 990 Q99741 CDC6 human S54 450914 RVkALPLsPRKRLGD X X -CDK2 CDK2 P24941 human MCL1 4170 Q07820 MCL1 human T163 455375 tDGsLPstPPPAEEE X 4579; 14765 -CDK2 CDK2 P24941 human Rb 5925 P06400 RB1 human T373 447982 VNVIPPHtPVRTVMN RB_A X -CDK2 CDK2 P24941 human SRC-1 8648 Q15788 NCOA1 human S997 18958509 LYSQPYSsPSPTANL X -CDK2 CDK2 P24941 human Myc 4609 P01106 MYC human S77 448586 LLPtPPLsPsRRsGL Myc_N X 13748 -CDK2 CDK2 P24941 human TSPYL2 64061 Q9H2G4 TSPYL2 human S20 3212187 RRLsssEsPQRDPPP X -CDK2 CDK2 P24941 human TNKS1BP1 85456 Q9C0C2 TNKS1BP1 human S691 452486 WLDDLLAsPPPsGGG X -CDK2 CDK2 P24941 human Rb-like 2 5934 Q08999 RBL2 human S952 449732 DSRsHQNsPtELNKD RB_B X -CDK2 CDK2 P24941 human B-Myb 4605 P10244 MYBL2 human T520 450112 DNtPHtPtPFkNALE Cmyb_C X -CDK2 CDK2 P24941 human BARD1 580 Q99728 BARD1 human S288 467302 PLAEQIEsPDTKSRN X -CDK2 CDK2 P24941 human NSBP1 79366 P82970 HMGN5 human T31 456124 sAMLVPVtPEVkPKR HMG14_17 X -CDK2 CDK2 P24941 human FOXK2 68837 Q3UCQ1 Foxk2 mouse S190 36124957 HLISPLPsPTGTISA X -CDK2 CDK2 P24941 human SPT5 6829 O00267 SUPT5H human T791 458817 tPMyGsQtPLQDGsR X -CDK2 CDK2 P24941 human MAP2 iso3 25595 P15146-3 Map2 rat S136 448323 ETVNLPPsPPPSPAS X 4541 -CDK2 CDK2 P24941 human GRASP55 26003 Q9H8Y8 GORASP2 human T225 470123 QMAGtPItPLKDGFT X -CDK2 CDK2 P24941 human PR 5241 P06401 PGR human S213 450155 SGAPVKPsPQAAAVE Prog_receptor X -CDK2 CDK2 P24941 human APC 324 P25054 APC human S1360 3188801 EFsSGAKsPsKsGAQ APC_u9 X -CDK2 CDK2 P24941 human Rb-like 2 5934 Q08999 RBL2 human S1044 449739 yPFVRtGsPRRIQLS X -CDK2 CDK2 P24941 human KLF10 7071 Q13118 KLF10 human S206 7320931 NIPCAAVsPNRSKCE X X -CDK2 CDK2 P24941 human TUBG1 7283 P23258 TUBG1 human S80 9831761 VIHSILNsPYAkLYN Tubulin X -CDK2 CDK2 P24941 human B-Myb 17865 P48972 Mybl2 mouse T497 450109 tPLHRDKtPLHQKYP Cmyb_C X -CDK2 CDK2 P24941 human PR 5241 P06401 PGR human S162 450156 PATQRVLsPLMSRSG Prog_receptor X -CDK2 CDK2 P24941 human TPX2 22974 Q9ULW0 TPX2 human T72 460008 NLQQAIVtPLkPVDN X X -CDK2 CDK2 P24941 human NPAT 4863 Q14207 NPAT human S775 2286404 LPTIILSsPTKsPTK NPAT_C X -CDK2 CDK2 P24941 human ELK4 2005 P28324 ELK4 human T194 41290001 SVIKFVTtPSKKPPV X X -CDK2 CDK2 P24941 human TFCP2 7024 Q12800 TFCP2 human T258 8046512 REKMEKRtPHEKEKY CP2 X -CDK2 CDK2 P24941 human MLL4 8085 O14686 KMT2D human T5374 9831697 TFTGETNtPYSkQFV X -CDK2 CDK2 P24941 human PML 5371 P29590 PML human S518 465867 PsTSkAVsPPHLDGP DUF3583 X X -CDK2 CDK2 P24941 human BAT2 7916 P48634 PRRC2A human T1353 9831624 LtPKAVGtPGGGGGG X -CDK2 CDK2 P24941 human CCNA2 890 P20248 CCNA2 human S154 3140800 PMDGSFEsPHTMDMS Cyclin_N2 X X -CDK2 CDK2 P24941 human INCA1 388324 Q0VD86 INCA1 human T182 12524604 QEEDRFLtPGRAQLL INCA1 X -CDK2 CDK2 P24941 human RPS27L 51065 Q71UM5 RPS27L human S27 7446456 KKkRLVQsPNsyFMD X -CDK2 CDK2 P24941 human MYST2 11143 O95251 KAT7 human T88 468239 QQQPtPVtPkKYPLR X -CDK2 CDK2 P24941 human NFAT90 3609 Q12906 ILF3 human S382 456735 EEDGEEKsPsKKKKK X X -CDK2 CDK2 P24941 human ANKRD17 26057 O75179 ANKRD17 human S2045 484761 yPVssPssPsPPAQP X -CDK2 CDK2 P24941 human ZNF609 23060 O15014 ZNF609 human T722 9831796 FTVNPALtPAKDKKK X -CDK2 CDK2 P24941 human MCM2 4171 P49736 MCM2 human S108 456310 DVEELtAsQREAAER MCM2_N X -CDK2 CDK2 P24941 human SF3B1 23451 O75533 SF3B1 human T354 452215 GGstPVLtPGKTPIG SF3b1 X -CDK2 CDK2 P24941 human PTPN2 iso2 5771 P17706-2 PTPN2 human S304 451134 LSPAFDHsPNKIMTE X X -CDK2 CDK2 P24941 human ORC1L 4998 Q13415 ORC1 human T375 11329800 AQNEAtstPHRIRRK X -CDK2 CDK2 P24941 human TOB2 10766 Q14106 TOB2 human S254 14161520 PAPQSQLsPNAKEFV PAM2 X X -CDK2 CDK2 P24941 human MCL1 4170 Q07820 MCL1 human T70 31857746 AsPPStLtPDSRRVA X X -CDK2 CDK2 P24941 human SAMHD1 25939 Q9Y3Z3 SAMHD1 human T592 468674 DVIAPLItPQkkEWN X 89930; 87593; 55092; 45205 -CDK2 CDK2 P24941 human ARID1A 8289 O14497 ARID1A human S363 3857177 RSHHAPMsPGssGGG X -CDK2 CDK2 P24941 human SPT5 6829 O00267 SUPT5H human S666 468817 VGGFAPMsPrISsPM X -CDK2 CDK2 P24941 human TICRR 90381 Q7Z2Z1 TICRR human T969 20798601 LTKSVAEtPVHKQIS Treslin_N X X -CDK2 CDK2 P24941 human EZH2 2146 Q15910 EZH2 human T416 10417699 EANsRCQtPIKMkPN X X -CDK2 CDK2 P24941 human UHRF1 iso2 29128 Q96T88-2 UHRF1 human S674 469962 GGPSRAGsPRRTSKK X -CDK2 CDK2 P24941 human SF3B1 23451 O75533 SF3B1 human T426 7989958 AGyVPIRtPARkLtA SF3b1 X -CDK2 CDK2 P24941 human FOXK2 68837 Q3UCQ1 Foxk2 mouse S200 1876808206 GTISAANsCPSSPRG X -CDK2 CDK2 P24941 human HN1L 90861 Q9H910 JPT2 human S97 483850 ktSDIFGsPVtAtsr X -CDK2 CDK2 P24941 human FOXO1A 56458 Q9R1E0 Foxo1 mouse S246 471071 EGGkSGksPRRRAAs X X -CDK2 CDK2 P24941 human PXR 8856 O75469 NR1I2 human S350 4668103 MQAISLFsPDRPGVL Hormone_recep X X -CDK2 CDK2 P24941 human FOXP3 20371 Q99JB6 Foxp3 mouse S19 12201088 PSLALGPsPGVLPSW X -CDK2 CDK2 P24941 human UHRF1 29128 Q96T88 UHRF1 human S661 469962 GGPSrAGsPRRTSKK X -CDK2 CDK2 P24941 human NBS1 4683 O60934 NBN human S432 483547 RIPNyQLsPtKLPsI X X -CDK2 CDK2 P24941 human Nogo iso2 Q9JK11-2 Rtn4 rat S16 468313 LVSSSTDsPPRPPPA X -CDK2 CDK2 P24941 human Rb 5925 P06400 RB1 human S608 447976 tAADMyLsPVRsPKK X 2181; 8147 -CDK2 CDK2 P24941 human CCDC95 283899 Q8NBZ0 INO80E human S154 9831639 ALQLPEPsPLRPKRE X -CDK2 CDK2 P24941 human SCML2 10389 Q9UQR0 SCML2 human S267 3216606 AsQHsMQsPQKTTLI X -CDK2 CDK2 P24941 human LARP 23367 Q6PKG0 LARP1 human T303 4928285 yVPVAPPtPAWQPEI X -CDK2 CDK2 P24941 human SCML2 10389 Q9UQR0 SCML2 human S590 3216624 sPLVGDIsPKssPHE X -CDK2 CDK2 P24941 human Rb 5925 P06400 RB1 human S807 447980 PGGNIyIsPLksPyk Rb_C X X 9308; 8974; 4277; 40283; 8957; 8516; 11917; 99274; 41359; 75864; 72443 -CDK2 CDK2 P24941 human CCNE1 898 P24864 CCNE1 human S399 454414 GLLtPPQsGKKQSSG X X -CDK2 CDK2 P24941 human Rb-like 2 5934 Q08999 RBL2 human S1112 449743 LLEDGSEsPAKRICP X -CDK2 CDK2 P24941 human MLK3 4296 Q16584 MAP3K11 human S770 448612 LISRPRPsPLRsRID X X -CDK2 CDK2 P24941 human MCM7 4176 P33993 MCM7 human S121 3189844 RDPGMVRsPQNQYPA MCM_N X X -CDK2 CDK2 P24941 human BMZF-2 11176 Q9UIF9 BAZ2A human S509 9831628 AAAFPtAsPANKDVS X -CDK2 CDK2 P24941 human SRC-1 8648 Q15788 NCOA1 human S1279 18958507 PPASGYQsPDMKAWQ X -CDK2 CDK2 P24941 human TTK 7272 P33981 TTK human S436 950200 VFSVskQsPPIsTSk X -CDK2 CDK2 P24941 human TNRC15 26058 Q6Y7W6 GIGYF2 human S30 483131 sItsPPLsPALPkYk X -CDK2 CDK2 P24941 human Akt1 207 P31749 AKT1 human T479 8086741 FsysAsGtA______ X X -CDK2 CDK2 P24941 human MCM2 4171 P49736 MCM2 human S53 473058 LPPFEDEsEGLLGtE MCM2_N X -CDK2 CDK2 P24941 human AML1 iso8 861 Q01196-8 RUNX1 human S293 454400 QYLGSIAsPSVHPAt X -CDK2 CDK2 P24941 human KI-67 4288 P46013 MKI67 human S357 452301 QYsQQQNsPQkHKNk X -CDK2 CDK2 P24941 human MCM2 4171 P49736 MCM2 human S139 454180 RRGLLyDsDEEDEER MCM2_N X 8861; 12958 -CDK2 CDK2 P24941 human Tau iso8 4137 P10636-8 MAPT human T205 447933 ssPGsPGtPGsRsRt X 25377; 43964; 53001; 49561; 20060; 33032; 30505; 20739; 98160 -CDK2 CDK2 P24941 human TSR1 55720 Q2NL82 TSR1 human T490 9831781 MFPDEVDtPRDVAAR RIBIOP_C X -CDK2 CDK2 P24941 human ORC1L 4998 Q13415 ORC1 human S258 11002790 TSCAsLDsPGRIKRK X -CDK2 CDK2 P24941 human SRC-1 8648 Q15788 NCOA1 human T1026 18958512 GTMPVQVtPPrGAFs X -CDK2 CDK2 P24941 human CDC25C 398119 P30309 cdc25c-b frog T138 449911 LPRLLCStPSFKKTS M-inducer_phosp X -CDK2 CDK2 P24941 human RANGAP1 19387 P46061 Rangap1 mouse S444 449222 stFLsFPsPEKLLRL RanGAP1_C X -CDK2 CDK2 P24941 human SOX2 20674 P48432 Sox2 mouse S253 6738002 VksEASSsPPVVtSS X 92186 -CDK2 CDK2 P24941 human CCNE1 898 P24864 CCNE1 human S387 454413 LsEQNRAsPLPSGLL X -CDK2 CDK2 P24941 human B-Myb 17865 P48972 Mybl2 mouse T490 452027 SQKVVVTtPLHRDKt Cmyb_C X -CDK2 CDK2 P24941 human PXR 8856 O75469 NR1I2 human S167 30259802 KTFDTTFsHFkNFRL X -CDK2 CDK2 P24941 human CTNNB1 84353 Q9WU82 Ctnnb1 rat T41 447583 GIHsGATtTAPsLSG X 9561; 9565; 4270; 13537; 41334; 60180 -CDK2 CDK2 P24941 human ERAL1 26284 O75616 ERAL1 human S173 9831664 LDTPGIIsPGkQKRH MMR_HSR1 X -CDK2 CDK2 P24941 human Rb 5925 P06400 RB1 human S811 448717 IyIsPLksPykIsEG Rb_C X X 9308; 8974; 4277; 40283; 8957; 8516; 11917; 41359; 75864; 63276 -CDK2 CDK2 P24941 human EZH2 2146 Q15910 EZH2 human T345 4957354 LtAERIKtPPkRPGG X X 45153 -CDK2 CDK2 P24941 human NPAT 4863 Q14207 NPAT human T1350 2286401 ISRTTsAtPLkDNTQ NPAT_C X X -CDK2 CDK2 P24941 human MCM2 4171 P49736 MCM2 human S27 452310 GNDPLtssPGRssRR X -CDK2 CDK2 P24941 human hnRNP K 3190 P61978 HNRNPK human S216 450148 ILDLIsEsPIkGRAQ X X -CDK2 CDK2 P24941 human Kv-beta2 29738 P62483 Kcnab2 rat S9 486012 YPESTTGsPARLSLR X X -CDK2 CDK2 P24941 human PXR 8856 O75469 NR1I2 human T133 30259803 KRKKSERtGtQPLGV X -CDK2 CDK2 P24941 human GR 24413 P06536 Nr3c1 rat S232 447968 PSKDTNEsPWRSDLL GCR X -CDK2 CDK2 P24941 human Ebp1 5036 Q9UQ80 PA2G4 human S34 35542202 IANrVLRsLVEASSS Peptidase_M24 X -CDK2 CDK2 P24941 human B-Myb 4605 P10244 MYBL2 human T515 450110 QkYSMDNtPHtPtPF Cmyb_C X -CDK2 CDK2 P24941 human PR 5241 P06401 PGR human S294 447987 APMAPGRsPLATTVM Prog_receptor X 13736 -CDK2 CDK2 P24941 human ZC3H11A 9877 O75152 ZC3H11A human T321 3175981 PETNIDKtPKKAQVs X -CDK2 CDK2 P24941 human SIRT2 22933 Q8IXJ6 SIRT2 human S368 482809 PNPsTsAsPKKsPPP X X -CDK2 CDK2 P24941 human INCA1 388324 Q0VD86 INCA1 human S23 12524602 CSRVVSRsPPPRLPS INCA1 X -CDK2 CDK2 P24941 human hnRNP H2 3188 P55795 HNRNPH2 human S104 455396 LkHtGPNsPDtANDG X -CDK2 CDK2 P24941 human PMS1 227099 Q8K119 Pms1 mouse T311 36126893 AEVDINLtPDKSQVL DNA_mis_repair X -CDK2 CDK2 P24941 human FZR1 51343 Q9UM11 FZR1 human S151 467929 DVsPYSLsPVsNkSQ X -CDK2 CDK2 P24941 human gephyrin 64845 Q03555 Gphn rat S283 2020113 LSttPsEsPRAQAts X -CDK2 CDK2 P24941 human WRN 7486 Q14191 WRN human S426 3196115 YKSTEHLsPNDNEND X -CDK2 CDK2 P24941 human SLAIN2 57606 Q9P270 SLAIN2 human S48 468079 AGsLGPGsPVrAGAs X -CDK2 CDK2 P24941 human p53 7157 P04637 TP53 human S315 447530 LPNNtsssPQPkkkP X 2528 -CDK2 CDK2 P24941 human ER-alpha 2099 P03372 ESR1 human S341 33663900 TRPFSEAsMMGLLTN Hormone_recep X -CDK2 CDK2 P24941 human ILRUN 64771 Q9H6K1 ILRUN human S215 3244958 GNFNPFAsPQkNRQs X -CDK2 CDK2 P24941 human TANC1 85461 Q9C0D5 TANC1 human S1564 9831758 SSQNPPPsPMPGRIA X -CDK2 CDK2 P24941 human AKIRIN2 55122 Q53H80 AKIRIN2 human S18 485531 LDFDPLLsPAsPKRR X -CDK2 CDK2 P24941 human POLL 27343 Q9UGP5 POLL human S167 2025641 ALLQTALsPPPPPtR X -CDK2 CDK2 P24941 human ALDH5A1 7915 P51649 ALDH5A1 human T181 9831752 VyGDIIHtPAKDRRA Aldedh X -CDK2 CDK2 P24941 human H1E 3008 P10412 H1-4 human T18 467971 APAPAEktPVkKKAR X -CDK2 CDK2 P24941 human TOR1AIP1 26092 Q5JTV8 TOR1AIP1 human S143 3198371 EQPPLQPsPVMtRRG X -CDK2 CDK2 P24941 human MCM4 4173 P33991 MCM4 human S54 448667 ELQPMPtsPGVDLQs X -CDK2 CDK2 P24941 human CEP76 79959 Q8TAP6 CEP76 human S83 2048409 VEQELPssPkQPICF X X -Bmx Etk P97504 mouse Pim1 18712 P06803 Pim1 mouse Y218 451014 EWIRYHRyHGRSAAV Pkinase X -NLK NLK Q9UBE8 human SRC-3 8202 Q9Y6Q9 NCOA3 human S857 453084 PPYNRAVsLDsPVsV X -NLK NLK Q9UBE8 human LEF-1 51176 Q9UJU2 LEF1 human S166 11499000 tysDEHFsPGSHPSH CTNNB1_binding X X -NLK NLK Q9UBE8 human SMAD4 4089 Q13485 SMAD4 human S138 10238801 YHYERVVsPGIDLSG X -NLK NLK Q9UBE8 human TCF7L2 6934 Q9NQB0 TCF7L2 human T212 11499002 TYSNEHFtPGNPPPH CTNNB1_binding X X -NLK NLK Q9UBE8 human ER-alpha 2099 P03372 ESR1 human S104 448099 FPPLNsVsPsPLMLL Oest_recep X -NLK NLK Q9UBE8 human LEF-1 51176 Q9UJU2 LEF1 human S132 14160436 YMSNGSLsPPIPRTS CTNNB1_binding X -NLK NLK Q9UBE8 human LEF-1 51176 Q9UJU2 LEF1 human S200 3865992 IPtFyPLsPGGVGQI CTNNB1_binding X -NLK NLK Q9UBE8 human SRC-3 8202 Q9Y6Q9 NCOA3 human S860 454106 NRAVsLDsPVsVGss X -NLK NLK Q9UBE8 human SMAD2 4087 Q15796 SMAD2 human S250 448795 TGsPAELsPTTLsPV X X 3104 -NLK NLK Q9UBE8 human SRC-3 8202 Q9Y6Q9 NCOA3 human S543 454108 SLLSTLSsPGPKLDN NCOA_u2 X -NLK NLK Q9UBE8 human SMAD4 4089 Q13485 SMAD4 human T9 10238800 DNMSITNtPTSNDAC X -NLK NLK Q9UBE8 human YAP1 10413 P46937 YAP1 human S128 485035 QHVRAHssPAsLQLG X X -NLK NLK Q9UBE8 human FOXO1A 2308 Q12778 FOXO1 human S329 448076 stIsGRLsPIMtEQD X -NLK NLK Q9UBE8 human SRC-3 8202 Q9Y6Q9 NCOA3 human T24 454110 KRKLPCDtPGQGLtC X 2979 -NLK NLK Q9UBE8 human STAT3 20848 P42227 Stat3 mouse S727 448191 NtIDLPMsPRTLDSL X X 9134; 9136; 34911; 94994; 49081; 58978; 87544; 71958; 50804 -NLK NLK Q9UBE8 human TCF7L2 6934 Q9NQB0 TCF7L2 human T201 11499003 PHHVHPLtPLITYSN CTNNB1_binding X X -NLK NLK Q9UBE8 human ER-alpha 2099 P03372 ESR1 human S118 448101 LHPPPQLsPFLQPHG Oest_recep X 2511 -NLK NLK Q9UBE8 human SMAD3 4088 P84022 SMAD3 human S208 451179 DAGsPNLsPNPMsPA X X -NLK NLK Q9UBE8 human ER-alpha 2099 P03372 ESR1 human S106 448100 PLNsVsPsPLMLLHP Oest_recep X -NLK NLK Q9UBE8 human SRC-3 8202 Q9Y6Q9 NCOA3 human S867 454107 sPVsVGssPPVKNIS X -NLK NLK Q9UBE8 human ER-alpha 2099 P03372 ESR1 human S167 448102 GGRERLAsTNDkGSM Oest_recep X 64508; 42101 -NLK NLK Q9UBE8 human Raptor 57521 Q8N122 RPTOR human S863 453732 LtQsAPAsPtNkGVH X X -NLK NLK Q9UBE8 human YAP1 22601 P46938 Yap1 mouse S113 485035 QHVRAHssPAsLQLG X -NLK NLK Q9UBE8 human LEF-1 51176 Q9UJU2 LEF1 human T265 23053149 IPHPAIVtPQVKQEH X -NLK NLK Q9UBE8 human LEF-1 51176 Q9UJU2 LEF1 human T155 11499001 SHAVHPLtPLItysD CTNNB1_binding X X -NLK NLK Q9UBE8 human SRC-3 8202 Q9Y6Q9 NCOA3 human S505 454109 SPVAGVHsPMAsSGN NCOA_u2 X -TGM2 TGM2 P21980 human H3 8350 P68431 H3C1 human S10 455676 tkQtArkstGGkAPr Histone X 9701; 9711; 9606; 3465; 3642; 3377; 3475; 3458; 5764; 47398; 8481; 8552; 53348; 29237; 66065; 43185; 64522; 52725 -TGM2 TGM2 P21980 human H3 8350 P68431 H3C1 human S28 455677 ATkAArksAPATGGV Histone X 9713 -ALPK1 AlphaK3 Q96QP1 human TIFA 92610 Q96CG3 TIFA human T9 50409900 tSFEDADtEEtVTCL X X -Wnk4 WNK4 Q80UE6 mouse STLK3 53416 Q9Z1W9 Stk39 mouse T243 456505 tRNKVRKtFVGtPCW Pkinase X -Wnk4 WNK4 Q80UE6 mouse STLK3 53416 Q9Z1W9 Stk39 mouse S383 456506 VRRVPGssGHLHKTE X -Wnk4 WNK4 Q80UE6 mouse WNK4 69847 Q80UE6 Wnk4 mouse S1196 5879855 PGIMRRNsLSGSSTG X -ENPP3 ENPP3 O14638 human ENPP3 5169 O14638 ENPP3 human T205 3753305 RAMYPTKtFPNHYTI Phosphodiest X -Ret Ret P35546 mouse Ret 19713 P35546 Ret mouse Y1016 449894 MMVKSRDyLDLAAST X -Ret Ret P35546 mouse Ret 19713 P35546 Ret mouse Y1063 447625 TWIENKLyGMSDPNW X -Ret Ret P35546 mouse Ret 5979 P07949 RET human Y1062 447625 TWIENkLyGMsDPNW X -EEF2K EEF2K O00418 human EEF2 1938 P13639 EEF2 human T57 448040 rAGEtRFtDtRkDEQ GTP_EFTU X X 2331 -EEF2K EEF2K O00418 human EEF2K 29904 O00418 EEF2K human S396 450812 TFDsLPssPssAtPH X -EEF2K EEF2K O00418 human EEF2K 29904 O00418 EEF2K human S366 447827 sPQVRtLsGSRPPLL X 3691 -EEF2K EEF2K O00418 human EEF2 P55823 EEF2 rabbit T56 448040 RAGEtRFtDtRKDEQ GTP_EFTU X -EEF2K EEF2K O00418 human EEF2K 29904 O00418 EEF2K human S78 450687 ssGsPANsFHFkEAW X -EEF2K EEF2K O00418 human STAT3 6774 P40763 STAT3 human Y705 448192 DPGsAAPyLktKFIC X X 4093; 9145; 4324; 9131; 9138; 4323; 4074; 4113; 48313; 20977; 25023; 8119; 52075; 52527; 73533; 61958; 73452; 16185; 74309 -EEF2K EEF2K O00418 human GSK3B 2932 P49841 GSK3B human S9 449111 SGRPRttsFAEsCkP X X 9336; 9331; 9327; 9323; 9322; 9325; 5558; 8566; 79774; 8466; 25462; 14026; 14332; 14310; 14630 -EEF2K EEF2K O00418 human EEF2K 29904 O00418 EEF2K human S441 23101751 EsENsGDsGyPsEkR X -EEF2K EEF2K O00418 human EEF2K 29904 O00418 EEF2K human S500 455998 RLHLPRAsAVALEVQ X X -EEF2K EEF2K O00418 human EEF2K 29904 O00418 EEF2K human T348 3150902 kLLQsAktILRGtEE X X -EEF2K EEF2K O00418 human EEF2K 29904 O00418 EEF2K human T353 4696223 AktILRGtEEKCGsP X -EEF2K EEF2K O00418 human EEF2K 29904 O00418 EEF2K human S445 483529 sGDsGyPsEkRGELD X X -EEF2K EEF2K O00418 human EEF2K 29904 O00418 EEF2K human S474 3150890 kYEsDEDsLGssGRV X -EEF2K EEF2K O00418 human PKM 5315 P14618 PKM human T129 27110042 GLIkGsGtAEVELkk PK X X -EEF2K EEF2K O00418 human EEF2 P55823 EEF2 rabbit T53 466363 ASARAGEtRFtDtRK GTP_EFTU X -EEF2K EEF2K O00418 human EEF2 P55823 EEF2 rabbit T58 450254 GEtRFtDtRKDEQER GTP_EFTU X -EEF2K EEF2K O00418 human EEF2 13629 P58252 Eef2 mouse T57 448040 RAGEtRFtDtRKDEQ GTP_EFTU X 2331 -Limk1 LIMK1 P53669 rat Cofilin-1 29271 P45592 Cfl1 rat S3 448444 _____MAsGVAVsDG X X 3313; 3311 -Limk1 LIMK1 P53669 rat Cofilin-1 1072 P23528 CFL1 human S3 448444 _____MAsGVAVsDG X 3313; 3311 -Map2k3 MKK3 O09110 mouse MEKK3 26406 Q61084 Map3k3 mouse S526 458796 MSGTGIRsVTGTPYW Pkinase X -PRKG1 PKG1 Q13976 human GSK3B 84027 P18266 Gsk3b rat S9 449111 SGRPRTTsFAESCKP X 9336; 9331; 9327; 9323; 9322; 9325; 5558; 8566; 79774; 8466; 25462; 14026; 14332; 14310; 14630 -PRKG1 PKG1 Q13976 human TRPC7 26946 Q9WVC5 Trpc7 mouse T15 11164436 KNMQRRHtTLREKGR X X -PRKG1 PKG1 Q13976 human GATA4 2626 P43694 GATA4 human S262 450013 IkPQRRLsAsRRVGL X X -PRKG1 PKG1 Q13976 human PKAR1A 5573 P10644 PRKAR1A human S101 454354 RRRRGAIsAEVYTEE X X -PRKG1 PKG1 Q13976 human CACNA1C 100101555 P15381 CACB rabbit S1928 455278 ASLGRRAsFHLECLK CAC1F_C X -PRKG1 PKG1 Q13976 human SRF 6722 P11831 SRF human T159 449631 DNkLRRYtTFsKRkT SRF-TF X -PRKG1 PKG1 Q13976 human VASP 7408 P50552 VASP human T278 448381 LARRRKAtQVGEktP X X -PRKG1 PKG1 Q13976 human RGS4 100009014 Q0R4E4 RGS4 rabbit S52 469585 VVVCQRVsQEEVKKW X -PRKG1 PKG1 Q13976 human mGluR7 81672 P35400 Grm7 rat S862 2846504 NVQKRKRsFKAVVTA X -PRKG1 PKG1 Q13976 human TXA2-R iso2 6915 P21731-2 TBXA2R human T332 18790000 TRPRRsLtLWPSLEY X -PRKG1 PKG1 Q13976 human Titin 84015 XP_008773743 Ttn rat S3986 27842905 REQASLFsEWLRNID X -PRKG1 PKG1 Q13976 human CBS 875 P35520 CBS human S227 50301801 LDQYRNAsNPLAHYD PALP X X -PRKG1 PKG1 Q13976 human TRPC6 7225 Q9Y210 TRPC6 human T70 470868 RLAHRRQtVLREKGR X X -PRKG1 PKG1 Q13976 human H1R 3269 P35367 HRH1 human S398 450937 WKRLRsHsRQyVSGL 7tm_1 X -PRKG1 PKG1 Q13976 human RGS18 64407 Q9NS28 RGS18 human S216 4772683 PTNLRRRsRsFTCNE X -PRKG1 PKG1 Q13976 human TXA2-R iso2 6915 P21731-2 TBXA2R human S330 18790001 LSTRPRRsLtLWPSL X -PRKG1 PKG1 Q13976 human TNNI3 511094 P08057 TNNI3 cow S25 448424 PPVRRRssANYRAYA Troponin-I_N X -PRKG1 PKG1 Q13976 human RYR1 100009540 P11716 RYR1 rabbit S2843 451818 KKKTRKIsQTAQTYD X -PRKG1 PKG1 Q13976 human Titin 84015 XP_008773743 Ttn rat S3658 29618902 ETSARGLsVQAFDSE X -PRKG1 PKG1 Q13976 human ENSA 2029 O43768 ENSA human S109 477819 DLPQRkssLVtskLA Endosulfine X -PRKG1 PKG1 Q13976 human FHOD1 29109 Q9Y613 FHOD1 human S1131 451843 AARERKRsRGNRKsL X X -PRKG1 PKG1 Q13976 human GTF2I 2969 P78347 GTF2I human S784 457075 GVPFRRPstFGIPRL GTF2I X X -PRKG1 PKG1 Q13976 human ORAI1 84876 Q96D31 ORAI1 human S34 48990000 sRRsRRRsGDGEPPG X -PRKG1 PKG1 Q13976 human PPP1R14A 94274 Q96A00 PPP1R14A human T38 449098 QkRHARVtVkYDRRE PP1_inhibitor X -PRKG1 PKG1 Q13976 human TRPC3 iso3 7222 Q13507-3 TRPC3 human T11 458335 SPSLRRMtVMREKGR X X -PRKG1 PKG1 Q13976 human RAP1GAP2 23108 Q684P5 RAP1GAP2 human S7 455267 _MFGRKRsVsFGGFG X X -PRKG1 PKG1 Q13976 human CACNB2 100009277 P54288 CAB2 rabbit S522 486359 SGTSRGLsRQETFDS X -PRKG1 PKG1 Q13976 human PKD2 18764 O35245 Pkd2 mouse S827 4696848 HSSRRRGsIssGVsY X -PRKG1 PKG1 Q13976 human STMN1 3925 P16949 STMN1 human S63 448557 AAEERRksHEAEVLk Stathmin X -PRKG1 PKG1 Q13976 human IP3R1 25262 P29994 Itpr1 rat S1589 450681 RNAARRDsVLAASRD X -PRKG1 PKG1 Q13976 human SF1 117855 NP_001104263 Sf1 rat S20 449919 PSkKRKRsRWNQDTM SF1-HH X -PRKG1 PKG1 Q13976 human H2B 615043 P62808 H2BC19 cow S32 447801 DGKKRKRsRKEsYSV Histone X -PRKG1 PKG1 Q13976 human RGS2 5997 P41220 RGS2 human S46 10772900 kDWKTRLsYFLQNSS X X -PRKG1 PKG1 Q13976 human SSB 20823 P32067 Ssb mouse S199 2862901 KNEERKQsKVEAKLK X -PRKG1 PKG1 Q13976 human PKD2 18764 O35245 Pkd2 mouse T719 25690300 KLKLKRNtVDAISES X -PRKG1 PKG1 Q13976 human PDE5A 281972 Q28156 PDE5A cow S92 448178 GTPTRKIsASEFDRP X -PRKG1 PKG1 Q13976 human Titin 7273 Q8WZ42 TTN human S4099 27842905 sEQPGLFsEWLRNIE X -PRKG1 PKG1 Q13976 human MYBPC3 17868 O70468 Mybpc3 mouse S690 1877150010 VTQGKkAsAGPHPDA I-set X -PRKG1 PKG1 Q13976 human Titin 22138 A2ASS6 Ttn mouse S4080 27842905 REQANLFsEWLRNID X -PRKG1 PKG1 Q13976 human TXA2-R 6915 P21731 TBXA2R human S331 470029 sTRPRsLsLQPQLtQ X -PRKG1 PKG1 Q13976 human PKG1 5592 Q13976 PRKG1 human S65 51573802 TtRAQGIsAEPQTYR X X -PRKG1 PKG1 Q13976 human IP3R1 25262 P29994 Itpr1 rat S1756 450682 RPSGRREsLTSFGNG X 3760; 8548 -PRKG1 PKG1 Q13976 human GTF2I 2969 P78347 GTF2I human S412 457074 GIPFRRPstYGIPRL GTF2I X X -PRKG1 PKG1 Q13976 human RGS2 5997 P41220 RGS2 human S64 10772901 kPKTGKKsKQQAFIk X X -PRKG1 PKG1 Q13976 human MYPT1 396020 Q90623 PPP1R12A chicken S694 451998 QARQSRRstQGVTLT X -PRKG1 PKG1 Q13976 human VASP 22323 P70460 Vasp mouse S153 448379 EHMERRVsNAGGPPA X 3111; 84519 -PRKG1 PKG1 Q13976 human TRPC1 7220 P48995 TRPC1 human S206 35542201 SAKNKKDsLRHSRFR TRP_2 X -PRKG1 PKG1 Q13976 human URB 151887 Q76M96 CCDC80 human S434 28735102 PQTTRRPsKATSLES X -PRKG1 PKG1 Q13976 human H1R 3269 P35367 HRH1 human S396 453404 FTWKRLRsHsRQyVS 7tm_1 X -PRKG1 PKG1 Q13976 human ARPP-19 10776 P56211 ARPP19 human S104 477874 DLPQRkPsLVAskLA Endosulfine X -PRKG1 PKG1 Q13976 human URB 151887 Q76M96 CCDC80 human S409 23071314 VITARRPsVsENLYP X -PRKG1 PKG1 Q13976 human PDE5A 8654 O76074 PDE5A human S102 448178 GTPTRKIsAsEFDRP X -PRKG1 PKG1 Q13976 human VASP 7408 P50552 VASP human S239 448380 GAKLRKVsKQEEASG X X 3114; 37565 -PRKG1 PKG1 Q13976 human RAP1B 5908 P61224 RAP1B human S179 451799 PGkARKKsscQLL__ X -PRKG1 PKG1 Q13976 human smMLCK 100009143 P29294 MYLK rabbit S1005 455821 GLSGRKSsTGSPTsP X -PRKG1 PKG1 Q13976 human BAD 12015 Q61337 Bad mouse S155 447863 GRELRRMsDEFEGsF Bcl-2_BAD X 9297 -PRKG1 PKG1 Q13976 human RHOA 387 P61586 RHOA human S188 449035 ARRGKKKsGCLVL__ X -PRKG1 PKG1 Q13976 human TNNI3 511094 P08057 TNNI3 cow S24 448423 PPPVRRRssANYRAY Troponin-I_N X -PRKG1 PKG1 Q13976 human TRPC6 22068 Q61143 Trpc6 mouse T69 470868 RLTHRRQtILREKGR X X -PRKG1 PKG1 Q13976 human PFKM 100345647 P00511 PFKM rabbit S775 458322 EHISRKRsGEATV__ X -PRKG1 PKG1 Q13976 human MYPT1 116670 Q10728 Ppp1r12a rat S696 451998 QARQSRRstQGVTLT X -PRKG1 PKG1 Q13976 human H1C 513971 P02253 H1-2 cow S36 450120 AGARRKAsGPPVSEL X -PRKG1 PKG1 Q13976 human Lasp-1 3927 Q14847 LASP1 human S146 448836 MEPERRDsQDGssyR X -PRKG1 PKG1 Q13976 human TRPC6 7225 Q9Y210 TRPC6 human S322 3363401 KNDYKKLsMQCKDFV X -PRKG1 PKG1 Q13976 human Titin 7273 Q8WZ42 TTN human S4185 5474103 IQQGAKtsLQEEMDs X -PRKG1 PKG1 Q13976 human VASP 22323 P70460 Vasp mouse S235 448380 GAKLRKVsKQEEASG X 3114; 37565 -PRKG1 PKG1 Q13976 human HSL 3991 Q05469 LIPE human S853 448803 IAEPMRRsVsEAALA X 4139 -PRKG1 PKG1 Q13976 human RYR2 20191 E9Q401 Ryr2 mouse S2807 448848 YNRTRRIsQtsQVsI X -PRKG1 PKG1 Q13976 human MLK3 26403 Q80XI6 Map3k11 mouse T278 448263 LAREWHKtTQMsAAG PK_Tyr_Ser-Thr X X -PRKG1 PKG1 Q13976 human PDE3A 54611 Q9Z0X4 Pde3a mouse S654 36132073 REPQRKAsACGTYTS X -PRKG1 PKG1 Q13976 human TSC2 7249 P49815 TSC2 human S1364 471941 IPIERVVssEGGRPs X -PRKG1 PKG1 Q13976 human TRPC1 7220 P48995 TRPC1 human T347 35542200 SGYRRKPtCKKIMTV X -PRKG1 PKG1 Q13976 human MYPT1 396020 Q90623 PPP1R12A chicken S667 478658 EVRERRRsYLTPVRD X 3048 -PRKG1 PKG1 Q13976 human GUCY1A1 497757 P19686 Gucy1a1 rat S64 3647001 SHPQRKTsRNRVYLH X -PRKG1 PKG1 Q13976 human GTF2I iso2 2969 P78347-2 GTF2I human S743 457075 GVPFRRPstFGIPRL GTF2I X -PRKG1 PKG1 Q13976 human SERT 6532 P31645 SLC6A4 human T276 456508 SIWKGVKtsGKVVWV SNF X X -PRKG1 PKG1 Q13976 human MYPT1 116670 Q10728 Ppp1r12a rat T697 448587 ARQSRRstQGVTLTD X 5163 -PRKG1 PKG1 Q13976 human MLK3 26403 Q80XI6 Map3k11 mouse S282 448262 WHKtTQMsAAGTYAW PK_Tyr_Ser-Thr X X -PRKG1 PKG1 Q13976 human KCNMA1 403984 Q28265 KCNMA1 dog S1084 466425 QSSSKKSsSVHSIPS X -PRKG1 PKG1 Q13976 human Titin 7273 Q8WZ42 TTN human S4092 29618901 ALQAAVAsEQPGLFs X -PRKG1 PKG1 Q13976 human TRPC3 7222 Q13507 TRPC3 human S336 458336 KNDYRKLsMQCKDFV X X -PRKG1 PKG1 Q13976 human PTS 5805 Q03393 PTS human S19 450662 AQVSRRIsFSASHRL PTPS X -PRKG1 PKG1 Q13976 human CBS 875 P35520 CBS human S525 50301802 YHSTGKSsQRQMVFG X X -PRKG1 PKG1 Q13976 human ARHGEF6 9459 Q15052 ARHGEF6 human S684 456737 GSSTRkDsIPQVLLP X -PRKG1 PKG1 Q13976 human Titin 7273 Q8WZ42 TTN human S4010 27842904 VRIEEGKsLRFPLAL X -PRKG1 PKG1 Q13976 human PFKM 100345647 P00511 PFKM rabbit S377 4707523 AMKLRGRsFMNNWEV X -PRKG1 PKG1 Q13976 human VASP 7408 P50552 VASP human S157 448379 EHIERRVsNAGGPPA X X 3111; 84519 -PRKG1 PKG1 Q13976 human Titin 7273 Q8WZ42 TTN human S11878 10029600 KEEVVLKsVLRKRPE X -PRKG1 PKG1 Q13976 human GTF2I iso2 2969 P78347-2 GTF2I human S371 457074 GIPFRRPsTYGIPRL GTF2I X -MAPK1 ERK2 P28482 human HELLS 3070 Q9NRZ9 HELLS human S503 9764950 EKEtIELsPtGRPKR SNF2-rel_dom X X -MAPK1 ERK2 P28482 human BRAF 673 P15056 BRAF human T401 452246 sTtGLsAtPPAsLPG X -MAPK1 ERK2 P28482 human Tau iso8 4137 P10636-8 MAPT human T231 449079 KKVAVVRtPPKsPss X 20473; 71429 -MAPK1 ERK2 P28482 human WTAP 9589 Q15007 WTAP human S341 3196721 AGYESVDsPtGsENs X X -MAPK1 ERK2 P28482 human NHE1 6548 P19634 SLC9A1 human S726 2509107 IDPAsPQsPEsVDLV X -MAPK1 ERK2 P28482 human SMAD4 17128 P97471 Smad4 mouse S367 1877718910 RFCLGQLsNVHRTEA MH2 X X -MAPK1 ERK2 P28482 human CRYAB 25420 P23928 Cryab rat S45 448748 FSTATSLsPFYLRPP Crystallin X -MAPK1 ERK2 P28482 human Kir6.2 16514 Q61743 Kcnj11 mouse S385 2103601 AKPKFSIsPDsLS__ X -MAPK1 ERK2 P28482 human NUP153 9972 P49790 NUP153 human T388 3191107 VyFkPsLtPsGEFRK Nup153 X X -MAPK1 ERK2 P28482 human IRS1 3667 P35568 IRS1 human S636 447506 sGDyMPMsPKsVSAP X 2388 -MAPK1 ERK2 P28482 human Fe65 322 O00213 APBB1 human T709 451149 PKRLGAHtP______ X X -MAPK1 ERK2 P28482 human PXN iso2 5829 P49023-2 PXN human S83 451113 FIHQQPQsssPVyGs Paxillin X -MAPK1 ERK2 P28482 human p90RSK 81771 Q63531 Rps6ka1 rat T359 447992 DTEFTSRtPRDsPGI Pkinase_C X 9344 -MAPK1 ERK2 P28482 human p90RSK 6195 Q15418 RPS6KA1 human T573 447993 AENGLLMtPCytANF Pkinase X 9346 -MAPK1 ERK2 P28482 human KLC1 171041 P37285 Klc1 rat S460 477826 YKACKVDsPTVTTTL X -MAPK1 ERK2 P28482 human Tau iso8 4137 P10636-8 MAPT human S199 447927 GDRsGyssPGsPGtP X X 29957 -MAPK1 ERK2 P28482 human FGFR2 2263 P21802 FGFR2 human S780 34500854 SQPLEQYsPsYPDTR X -MAPK1 ERK2 P28482 human SHARPIN 81858 Q9H0F6 SHARPIN human S146 31883820 ACPVsLPsPPEAStL X X -MAPK1 ERK2 P28482 human NPAS4 225872 Q8BGD7 Npas4 mouse S580 1871095702 KLPPsPSsPGNGDCT X -MAPK1 ERK2 P28482 human TH iso2 7054 P07101-2 TH human S58 448544 SYTPTPRsPRFIGRR TOH_N X -MAPK1 ERK2 P28482 human DET1 76375 Q9D0A0 Det1 mouse S66 63280109 PCFLRKFsPDGRYFI X -MAPK1 ERK2 P28482 human SPHK1 8877 Q9NYA1 SPHK1 human S225 460682 VGSKTPAsPVVVQQG X X -MAPK1 ERK2 P28482 human ATF-2 1386 P15336 ATF2 human T71 448225 IVADQtPtPtRFLkN X X 9225; 9221; 5112; 94125; 13850; 40749; 15411; 24329; 61584; 27934; 92109; 20534; 35858 -MAPK1 ERK2 P28482 human p70S6K 6198 P23443 RPS6KB1 human S447 448357 GsPRtPVsPVkFsPG X 9204 -MAPK1 ERK2 P28482 human PDE4B 5142 Q07343 PDE4B human S659 471380 YQSMIPQsPSPPLDE X -MAPK1 ERK2 P28482 human GRASP55 26003 Q9H8Y8 GORASP2 human T222 470124 LPGQMAGtPItPLKD X -MAPK1 ERK2 P28482 human PARVA 55742 Q9NVD7 PARVA human S4 4270096 ____MAtsPQKsPsV X -MAPK1 ERK2 P28482 human TACE 6868 P78536 ADAM17 human T735 449804 kPFPAPQtPGRLQPA X X -MAPK1 ERK2 P28482 human SMAD1 4086 Q15797 SMAD1 human S195 451174 PNSSYPNsPGSSSSt X -MAPK1 ERK2 P28482 human REST 5978 Q13127 REST human S861 36320700 sVsTEDLsPPsPPLP X X -MAPK1 ERK2 P28482 human SMAD1 4086 Q15797 SMAD1 human S187 451173 NSHPFPHsPNSSYPN X -MAPK1 ERK2 P28482 human STIM1 6786 Q13586 STIM1 human S608 3195758 PsAPPGGsPHLDSSR X -MAPK1 ERK2 P28482 human TOB1 10140 P50616 TOB1 human S154 455536 SSVSSsPsPPFGHSA X X -MAPK1 ERK2 P28482 human TSC2 7249 P49815 TSC2 human S664 455575 KkTSGPLsPPTGPPG Tuberin X 40729 -MAPK1 ERK2 P28482 human Bcl-2 596 P10415 BCL2 human T74 448632 ARtsPLQtPAAPGAA X -MAPK1 ERK2 P28482 human NPAS4 225872 Q8BGD7 Npas4 mouse T427 1869686800 LVCTPPYtPHQPGGC X -MAPK1 ERK2 P28482 human ASL 435 P04424 ASL human S417 1880040200 LQELQTIsPLFSGDV X X -MAPK1 ERK2 P28482 human p70S6K 83840 P67999 Rps6kb1 rat S447 448357 GsPRtPVsPVKFsPG X 9204 -MAPK1 ERK2 P28482 human PXN iso2 5829 P49023-2 PXN human S126 450227 sFPNKQKsAEPsPtV Paxillin X -MAPK1 ERK2 P28482 human DUSP16 80824 Q9BY84 DUSP16 human S446 449606 TNKLCQFsPVQELSE X -MAPK1 ERK2 P28482 human PSD-95 29495 P31016 Dlg4 rat T287 469607 TDyPtAMtPTsPRRY PDZ_assoc X -MAPK1 ERK2 P28482 human MITF iso9 4286 O75030-9 MITF human S73 450264 PGSSAPNsPMAMLTL MITF_TFEB_C_3_N X X -MAPK1 ERK2 P28482 human ELK1 13712 P41969 Elk1 mouse T354 22725900 QAPGPALtPSLLPTH X -MAPK1 ERK2 P28482 human PARP1 142 P09874 PARP1 human S372 463804 VAAtPPPstAsAPAA X -MAPK1 ERK2 P28482 human MTMR2 8898 Q13614 MTMR2 human S58 3195800 StSADNFsPDLRVLR X X -MAPK1 ERK2 P28482 human ELK1 13712 P41969 Elk1 mouse S390 449757 LsPIAPRsPAKLSFQ X -MAPK1 ERK2 P28482 human KLF8 11279 O95600 KLF8 human S48 56672701 EYRSNMTsPTLLDAN X -MAPK1 ERK2 P28482 human TORC3 64784 Q6UUV7 CRTC3 human S391 3203130 RRRQPPVsPLtLsPG X -MAPK1 ERK2 P28482 human DRP1 74006 Q8K1M6 Dnm1l mouse S622 454690 PIPIMPAsPQKGHAV X 3455; 4494; 63940 -MAPK1 ERK2 P28482 human WTAP 9589 Q15007 WTAP human S306 453808 tEDDFPssPGNGNKs X -MAPK1 ERK2 P28482 human p300 2033 Q09472 EP300 human T1960 486261 QHQMPPMtPMAPMGM X -MAPK1 ERK2 P28482 human STMN3 50861 Q9NZ72 STMN3 human S68 454282 PSDLsPEsPMLssPP Stathmin X -MAPK1 ERK2 P28482 human RBM17 84991 Q96I25 RBM17 human S222 3209223 EEQDRPRsPtGPsNs X X -MAPK1 ERK2 P28482 human JunD 16478 P15066 Jund mouse S90 473544 APDGLLAsPDLGLLK Jun X -MAPK1 ERK2 P28482 human LYL1 4066 P12980 LYL1 human S36 15624701 APPPKPAsPGPPQVE X -MAPK1 ERK2 P28482 human NIPA 232679 Q80YV2 Zc3hc1 mouse S353 449745 PIVsRtRsWEsssPV X -MAPK1 ERK2 P28482 human SP1 6667 P08047 SP1 human S59 452233 GGQEsQPsPLALLAA X X -MAPK1 ERK2 P28482 human RAGE 11596 Q62151 Ager mouse S376 4731271 EERKAPEsQEDEEER X -MAPK1 ERK2 P28482 human DUSP5 1847 Q16690 DUSP5 human S346 10206800 IGHLQTLsPDMQGAY X -MAPK1 ERK2 P28482 human CASP9 842 P55211 CASP9 human T125 449563 PEVLRPEtPRPVDIG X X -MAPK1 ERK2 P28482 human DUSP6 1848 Q16828 DUSP6 human S159 455265 DGSCSSSsPPLPVLG X X -MAPK1 ERK2 P28482 human WAVE2 10163 Q9Y6W5 WASF2 human S308 12626400 PPAPPLGsPPGPKPG X -MAPK1 ERK2 P28482 human SRC-1 8648 Q15788 NCOA1 human T1179 449063 NYGTNPGtPPASTsP DUF1518 X -MAPK1 ERK2 P28482 human ER-alpha 2099 P03372 ESR1 human S104 448099 FPPLNsVsPsPLMLL Oest_recep X X -MAPK1 ERK2 P28482 human NCAM1 iso1 4684 P13591-1 NCAM1 human T803 15721468 HTEPNETtPLTEPEK X -MAPK1 ERK2 P28482 human PSD-93 64053 Q63622 Dlg2 rat S323 472024 KTSLPPIsPGRysPI PDZ_assoc X -MAPK1 ERK2 P28482 human STIM1 6786 Q13586 STIM1 human S575 468876 LVEKLPDsPALAKkA X X -MAPK1 ERK2 P28482 human PKM 18746 P52480 Pkm mouse S37 476070 MCRLDIDsAPItARN X -MAPK1 ERK2 P28482 human CENPE 1062 Q02224 CENPE human S2654 459191 sRsKsLPsPHPVRYF X -MAPK1 ERK2 P28482 human CTNND1 1500 O60716 CTNND1 human T906 469141 sLDNNystPNERGDH X -MAPK1 ERK2 P28482 human CBP 1387 Q92793 CREBBP human S93 20615901 IGNVSASsPVQQGLG X -MAPK1 ERK2 P28482 human ARRB2 409 P32121 ARRB2 human S14 23083983 TRVFKKssPNCKLtV X -MAPK1 ERK2 P28482 human AML1 iso8 861 Q01196-8 RUNX1 human S276 454399 DTRQIQPsPPWSYDQ X -MAPK1 ERK2 P28482 human Oct4 5460 Q01860 POU5F1 human T118 25236706 sPEPCtVtPGAVkLE X -MAPK1 ERK2 P28482 human RGS19 10287 P49795 RGS19 human S151 447873 EDyVsILsPkEVSLD RGS X X -MAPK1 ERK2 P28482 human CACNB1 50688 P54283 Cacnb1 rat S348 459046 IVYIKITsPKVLQRL Guanylate_kin X -MAPK1 ERK2 P28482 human MAFA 389692 Q8NHW3 MAFA human S14 1713900 MGAELPSsPLAIEYV X X -MAPK1 ERK2 P28482 human NG2 81651 Q00657 Cspg4 rat T2314 483998 ELLQFCRtPNPALRN X -MAPK1 ERK2 P28482 human FRA2 14284 P47930 Fosl2 mouse T322 14573760 SDSLNsPtLLAL___ X -MAPK1 ERK2 P28482 human Fos 2353 P01100 FOS human S374 448482 PSSDSLSsPtLLAL_ X -MAPK1 ERK2 P28482 human JAK2 16452 Q62120 Jak2 mouse S523 465671 GISDVQIsPtLQRHN X -MAPK1 ERK2 P28482 human MCR 4306 P08235 NR3C2 human S196 25692901 EKSPSVCsPLNMTSS X -MAPK1 ERK2 P28482 human Abi-1 10006 Q8IZP0 ABI1 human S410 12626407 DIPMFDDsPPPPPPP X -MAPK1 ERK2 P28482 human NUP214 8021 P35658 NUP214 human S1809 10296401 NAPAFGQsPGFGQGG X -MAPK1 ERK2 P28482 human ELK1 13712 P41969 Elk1 mouse T337 2751400 GGQGPERtPGSGTSS X -MAPK1 ERK2 P28482 human SMAD2 4087 Q15796 SMAD2 human S255 448796 ELsPTTLsPVNHsLD X 3104 -MAPK1 ERK2 P28482 human TOP2A 7153 P11388 TOP2A human S1247 452238 kNENtEGsPQEDGVE X -MAPK1 ERK2 P28482 human Fos 2353 P01100 FOS human T232 448491 GGLPEVAtPESEEAF X -MAPK1 ERK2 P28482 human ELK1 13712 P41969 Elk1 mouse T369 22725901 TLtPVLLtPSSLPPS X -MAPK1 ERK2 P28482 human p67phox 4688 P19878 NCF2 human T233 457386 EPPPRPKtPEIFRAL X -MAPK1 ERK2 P28482 human PDX1 3651 P52945 PDX1 human S66 458402 QGsPPDIsPYEVPPL X -MAPK1 ERK2 P28482 human RBPMS 19663 Q9WVB0 Rbpms mouse T113 3208557 AKNKLVGtPNPstPL X X -MAPK1 ERK2 P28482 human DUSP1 1843 P28562 DUSP1 human S323 457718 HCSAEAGsPAMAVLD X X -MAPK1 ERK2 P28482 human PKR 5610 P19525 EIF2AK2 human T451 448089 kRtRSKGtLRyMsPE Pkinase X -MAPK1 ERK2 P28482 human TAGLN2 8407 P37802 TAGLN2 human S145 31885453 ArDDGLFsGDPNWFP X X -MAPK1 ERK2 P28482 human PML iso4 5371 P29590-4 PML human T28 451468 PTMPPPEtPSEGRQP X X -MAPK1 ERK2 P28482 human eNOS 4846 P29474 NOS3 human S600 34729904 MSGPYNSsPRPEQHK Flavodoxin_1 X X -MAPK1 ERK2 P28482 human PITPNM1 9600 O00562 PITPNM1 human T1223 451457 AEREGPGtPPTTLAr X -MAPK1 ERK2 P28482 human GLE1 2733 Q53GS7 GLE1 human S99 18010022 ssAFsPAsPAtPNGT X -MAPK1 ERK2 P28482 human GLI1 2735 P08151 GLI1 human S116 1877717202 FINSRCTsPGGSYGH X -MAPK1 ERK2 P28482 human RORC 6097 P51449 RORC human S205 4708350 ASCHLEYsPERGKAE X X -MAPK1 ERK2 P28482 human RSK2 110651 P18654 Rps6ka3 mouse T577 450152 AENGLLMtPCYtANF Pkinase X -MAPK1 ERK2 P28482 human Fe65 322 O00213 APBB1 human S175 451146 EEEEDLSsPPGLPEP X X -MAPK1 ERK2 P28482 human PPAR-gamma 19016 P37238 Pparg mouse S273 15175800 TGkTTDKsPFVIYDM X X -MAPK1 ERK2 P28482 human JunD 16478 P15066 Jund mouse S100 456168 LGLLKLAsPELERLI Jun X 9164 -MAPK1 ERK2 P28482 human Fe65 322 O00213 APBB1 human S347 451148 TFPAQSLsPEPLPQE X X -MAPK1 ERK2 P28482 human FHOD1 29109 Q9Y613 FHOD1 human S498 1984218 PAARtPQsPAPCVLL X -MAPK1 ERK2 P28482 human AML1 iso8 861 Q01196-8 RUNX1 human T300 454403 sPSVHPAtPIsPGRA X -MAPK1 ERK2 P28482 human Raptor 57521 Q8N122 RPTOR human S696 11315003 EKNyALPsPAttEGG X X -MAPK1 ERK2 P28482 human Tau iso8 4137 P10636-8 MAPT human S396 449081 GAEIVyKsPVVsGDt X X 9632 -MAPK1 ERK2 P28482 human ARRB1 408 P49407 ARRB1 human S412 447493 EEEDGtGsPQLNNR_ X X 2416 -MAPK1 ERK2 P28482 human DUSP6 1848 Q16828 DUSP6 human S197 455266 SATDSDGsPLSNSQP X X -MAPK1 ERK2 P28482 human p300 328572 B2RWS6 Ep300 mouse S2276 486262 PAQPNPMsPQQHMLP X X -MAPK1 ERK2 P28482 human SERT 6532 P31645 SLC6A4 human T616 7576402 IKsItPEtPTEIPCG X -MAPK1 ERK2 P28482 human eNOS 287024 P29473 NOS3 cow S116 448638 RKLQTRPsPGPPPAE X 9575 -MAPK1 ERK2 P28482 human CIITA 4261 P33076 CIITA human S280 471421 TVHGLPTsPDRPGsT X X -MAPK1 ERK2 P28482 human 4E-BP1 116636 Q62622 Eif4ebp1 rat S64 447527 FLMECRNsPVAKtPP eIF_4EBP X 9451; 9456 -MAPK1 ERK2 P28482 human Tau iso8 4137 P10636-8 MAPT human S404 449082 PVVsGDtsPRHLsNV X 35834; 20194; 98523; 91600; 49562 -MAPK1 ERK2 P28482 human TNF-R1 21937 P25118 Tnfrsf1a mouse S291 25573802 FStPGFSsPVSStPI X -MAPK1 ERK2 P28482 human smMLCK 100009143 P29294 MYLK rabbit S1011 468782 SsTGSPTsPLTAERL X -MAPK1 ERK2 P28482 human MAPKAPK2 9261 P49137 MAPKAPK2 human S272 448268 SNHGLAIsPGMKTRI Pkinase X -MAPK1 ERK2 P28482 human SRC-1 8648 Q15788 NCOA1 human S1185 449064 GtPPASTsPFSQLAA DUF1518 X -MAPK1 ERK2 P28482 human TPD52 7163 P55327 TPD52 human S40 17555377 GNssPPGsPTLQKFG X X -MAPK1 ERK2 P28482 human PPAR-gamma 5468 P37231 PPARG human S112 448062 AIkVEPAsPPYYSEK X -MAPK1 ERK2 P28482 human Fos 314322 P12841 Fos rat T331 448484 CtPVVTCtPSCTTYT X -MAPK1 ERK2 P28482 human BIM 10018 O43521 BCL2L11 human S69 449330 GPLAPPAsPGPFATR X X 4581; 4585 -MAPK1 ERK2 P28482 human MCTS1 28985 Q9ULC4 MCTS1 human T81 26348501 REGPFYPtLRLLHkY Pre-PUA X -MAPK1 ERK2 P28482 human hnRNP E2 5094 Q15366 PCBP2 human S272 482918 FsGIEsssPEVkGyW X X -MAPK1 ERK2 P28482 human PDE4D iso5 5144 Q08499-5 PDE4D human S413 451090 YQSTIPQsPSPAPDD X X -MAPK1 ERK2 P28482 human HePTP 5778 P35236 PTPN7 human S93 448310 ALQRQPPsPKQLEEE X -MAPK1 ERK2 P28482 human ER-beta 13983 O08537 Esr2 mouse S87 447915 WPTSGHLsPLATHCQ ERbeta_N X -MAPK1 ERK2 P28482 human BANP 54971 Q8N9N5 BANP human T337 41301700 VkSFSRRtPNSSSYC X -MAPK1 ERK2 P28482 human SYN1 24949 P09951 Syn1 rat S62 451572 stAAPVAsPAAPsPG X -MAPK1 ERK2 P28482 human NCAM-L1 3897 P32004 L1CAM human S1204 472276 GDIKPLGsDDSLADy Bravo_FIGEY X -MAPK1 ERK2 P28482 human eIF2B-epsilon 192234 Q64350 Eif2b5 rat S539 449906 ELDsRAGsPQLDDIR X -MAPK1 ERK2 P28482 human Tau iso8 4137 P10636-8 MAPT human S262 447930 NVKskIGstENLkHQ Tubulin-binding X -MAPK1 ERK2 P28482 human BTG2 12227 Q04211 Btg2 mouse S147 455911 QMMLGRSsPsKNYVM X -MAPK1 ERK2 P28482 human CCNB1 891 P14635 CCNB1 human S126 448814 PILVDTAsPsPMETs X -MAPK1 ERK2 P28482 human p300 2033 Q09472 EP300 human S2279 486262 PVQPNPMsPQQHMLP X X -MAPK1 ERK2 P28482 human NANOG 79923 Q9H9S0 NANOG human S52 31960309 MPHTEtVsPLPssMD X -MAPK1 ERK2 P28482 human Trap170 9282 O60244 MED14 human S986 452549 NEDDNPPsPIGGDMM X -MAPK1 ERK2 P28482 human ELK1 13712 P41969 Elk1 mouse S423 469193 LStPVVLsPGPQKP_ X -MAPK1 ERK2 P28482 human hnRNP K 3190 P61978 HNRNPK human S284 448185 rrDyDDMsPrrGPPP X -MAPK1 ERK2 P28482 human TPPP 11076 O94811 TPPP human S18 456612 ANRtPPKsPGDPskD X -MAPK1 ERK2 P28482 human NFL 4747 P07196 NEFL human T21 2872004 ykRRYVEtPrVHISS Filament_head X -MAPK1 ERK2 P28482 human eNOS 287024 P29473 NOS3 cow S602 34729904 MSGPYNSsPRPEQHK Flavodoxin_1 X -MAPK1 ERK2 P28482 human FOXO3A 2309 O43524 FOXO3 human S294 472326 QLskWPGsPtsRsSD X X 5538 -MAPK1 ERK2 P28482 human NEUROD1 18012 Q60867 Neurod1 mouse S162 465677 EILRSGKsPDLVSFV Neuro_bHLH X -MAPK1 ERK2 P28482 human SHARPIN 81858 Q9H0F6 SHARPIN human T309 1879811806 APREAPAtGPsPQHP X -MAPK1 ERK2 P28482 human TORC2 200186 Q53ET0 CRTC2 human S238 1870757301 DAkKLSSsSSRPRsC TORC_M X -MAPK1 ERK2 P28482 human Fos 14281 P01101 Fos mouse S32 470080 DSLSYYHsPADSFSS X 5348; 8709; 8677; 99325 -MAPK1 ERK2 P28482 human MEK1 5604 Q02750 MAP2K1 human T292 448287 EtPPRPRtPGRPLss Pkinase X X 26975 -MAPK1 ERK2 P28482 human eNOS 287024 P29473 NOS3 cow T46 34729903 SRAPAPAtPHAPDHS X -MAPK1 ERK2 P28482 human ADRB3 11556 P25962 Adrb3 mouse S247 40508998 GRFsPEEsPPsPSRS 7tm_1 X -MAPK1 ERK2 P28482 human Kv4.2 Q63881 Kcnd2 rat S616 457613 EGDDRPEsPEYSGGN X -MAPK1 ERK2 P28482 human TH 7054 P07101 TH human S62 448544 SYTPTPRsPRFIGRR TOH_N X -MAPK1 ERK2 P28482 human ASB2 51676 Q96Q27 ASB2 human S371 29618900 RIRRSGVsPLHLAAE Ank_2 X -MAPK1 ERK2 P28482 human FRA2 2355 P15408 FOSL2 human T322 14573760 SDsLNsPtLLAL___ X -MAPK1 ERK2 P28482 human CK2A1 1457 P68400 CSNK2A1 human S362 449986 ISSVPtPsPLGPLAG X X -MAPK1 ERK2 P28482 human PIAS1 300772 A9UK05 Pias1 rat S503 3177703 LSLPHQAsPVSRTPS X -MAPK1 ERK2 P28482 human CAD 101843763 P08955 Cad hamster T456 451248 KVYFLPItPHYVTQV X -MAPK1 ERK2 P28482 human NUP50 10762 Q9UKX7 NUP50 human S315 4957816 TQSkPVSsPFPTkPL X X -MAPK1 ERK2 P28482 human BRAF 673 P15056 BRAF human T753 460657 yACAsPKtPIQAGGy X -MAPK1 ERK2 P28482 human PDE4C iso2 5143 Q08493-2 PDE4C human S535 471381 YQSKIPRsPSDLTNP X -MAPK1 ERK2 P28482 human PML iso4 5371 P29590-4 PML human S527 451472 PHLDGPPsPRsPVIG DUF3583 X X -MAPK1 ERK2 P28482 human NDEL1 81565 Q9GZM8 NDEL1 human T219 468252 AsLsLPAtPVGKGTE NUDE_C X -MAPK1 ERK2 P28482 human smMLCK 4638 Q15746 MYLK human S1779 468782 sstGsPtsPLNAEKL X -MAPK1 ERK2 P28482 human capicua 23152 Q96RK0 CIC human S1389 4952030 sPRAILGsYRKKRKN X -MAPK1 ERK2 P28482 human SP3 6670 Q02447 SP3 human S73 1199100 CsKIGPPsPGDDEEE X X -MAPK1 ERK2 P28482 human KIBRA 23286 Q8IX03 WWC1 human S548 30312500 SsPSPPCsPLMADPL X X -MAPK1 ERK2 P28482 human FGFR1 2260 P11362 FGFR1 human S777 2721300 SMPLDQysPsFPDTR X -MAPK1 ERK2 P28482 human GSK3B 2932 P49841 GSK3B human T43 456221 kVTTVVAtPGQGPDR X -MAPK1 ERK2 P28482 human Lck 3932 P06239 LCK human S59 447820 EGSNPPAsPLQDNLV X -MAPK1 ERK2 P28482 human LIFR 3977 P42702 LIFR human S1044 450385 WNLVsPDsPRsIDSN X X -MAPK1 ERK2 P28482 human Cortactin 2017 Q14247 CTTN human S405 447700 KtQtPPVsPAPQPtE X X -MAPK1 ERK2 P28482 human RRas2 22800 P62070 RRAS2 human S186 484150 QEQECPPsPEPtRkE X -MAPK1 ERK2 P28482 human PDE4D iso2 5144 Q08499-2 PDE4D human S579 451090 YQSTIPQsPSPAPDD X X -MAPK1 ERK2 P28482 human SHARPIN 81858 Q9H0F6 SHARPIN human S165 3245774 PEADLPRsPGNLtER X -MAPK1 ERK2 P28482 human IP3R1 16438 P11881 Itpr1 mouse S436 469626 AFAIVPVsPAEVRDL X X -MAPK1 ERK2 P28482 human TFAM 7019 Q00059 TFAM human S177 33402212 FQEAKGDsPQEKLKT HMG_box_2 X X -MAPK1 ERK2 P28482 human Caldesmon iso4 800 Q05682-4 CALD1 human S534 448466 QSVDKVTsPTKV___ X -MAPK1 ERK2 P28482 human TCF8 25705 Q62947 Zeb1 rat T867 469215 DQNDSDCtPPKKKTR X -MAPK1 ERK2 P28482 human Myc 4609 P01106 MYC human T73 448496 kkFELLPtPPLsPsR Myc_N X 46650 -MAPK1 ERK2 P28482 human Fe65 322 O00213 APBB1 human S287 451147 WEPPGRAsPsQGSSP X X -MAPK1 ERK2 P28482 human SMAD1 4086 Q15797 SMAD1 human S206 451175 SSStYPHsPTSSDPG X 9553; 5753 -MAPK1 ERK2 P28482 human ADD1 118 P35611 ADD1 human S358 452287 AKsRsPGsPVGEGtG X X -MAPK1 ERK2 P28482 human MCR 4306 P08235 NR3C2 human S263 18503884 NVGsPLssPLSSMKS X -MAPK1 ERK2 P28482 human MCR 4306 P08235 NR3C2 human S227 25692900 FGSFPVHsPITQGTP X -MAPK1 ERK2 P28482 human SMAD2 4087 Q15796 SMAD2 human S250 448795 TGsPAELsPTTLsPV X 3104 -MAPK1 ERK2 P28482 human FAM195B 348262 C9JLW8 MCRIP1 human T30 9322247 PsSsEIFtPAHEENV FAM195 X X -MAPK1 ERK2 P28482 human p90RSK 81771 Q63531 Rps6ka1 rat S363 447989 TSRtPRDsPGIPPsA Pkinase_C X 9344 -MAPK1 ERK2 P28482 human DET1 76375 Q9D0A0 Det1 mouse S458 63280108 SAQSYSGsPYLDLSL Det1 X -MAPK1 ERK2 P28482 human GTF2I iso2 2969 P78347-2 GTF2I human S633 452350 QsPKRPRsPGSNSKV X -MAPK1 ERK2 P28482 human PPAR-gamma 19016 P37238 Pparg mouse S112 448062 AIkVEPAsPPYYSEK X -MAPK1 ERK2 P28482 human DHPS 1725 P49366 DHPS human S233 1870426002 KNHIPVFsPALTDGS DS X X -MAPK1 ERK2 P28482 human TNF-R1 21937 P25118 Tnfrsf1a mouse S299 450967 PVSStPIsPIFGPSN X -MAPK1 ERK2 P28482 human SPHK2 56848 Q9NRA0 SPHK2 human T614 477182 AFRLEPLtPRGVLTV YegS_C X X -MAPK1 ERK2 P28482 human STIM1 20866 P70302 Stim1 mouse S608 3195758 PSVPPGGsPLLDSSH X X -MAPK1 ERK2 P28482 human eNOS 287024 P29473 NOS3 cow S58 34729905 DHSPAPNsPTLTRPP X -MAPK1 ERK2 P28482 human Tau iso8 4137 P10636-8 MAPT human T153 449076 DGKtKIAtPRGAAPP X -MAPK1 ERK2 P28482 human E2A iso2 6929 P15923-2 TCF3 human S359 465682 sPStPVGsPQGLAGT X -MAPK1 ERK2 P28482 human JunD 16478 P15066 Jund mouse T117 473545 SNGLVTTtPTSTQFL Jun X -MAPK1 ERK2 P28482 human PTP-SL iso2 19279 Q62132-2 Ptprr mouse T253 450119 EPFVAVStPREKVAM X -MAPK1 ERK2 P28482 human SRC-1 8648 Q15788 NCOA1 human S395 449116 PsVNPsIsPAHGVAR X -MAPK1 ERK2 P28482 human amphiphysin 218038 Q7TQF7 Amph mouse S293 465542 PAPVRPRsPsQtRKG X -MAPK1 ERK2 P28482 human TNF-R1 21937 P25118 Tnfrsf1a mouse S273 450968 PAPsPAFsPTSGFNP X -MAPK1 ERK2 P28482 human DNMT3A 1788 Q9Y6K1 DNMT3A human S255 4700048 QQPTDPAsPTVATtP X -MAPK1 ERK2 P28482 human WAVE2 10163 Q9Y6W5 WASF2 human S296 9764438 PKRssVVsPsHPPPA X -MAPK1 ERK2 P28482 human CIITA 4261 P33076 CIITA human S288 2286408 PDRPGsTsPFAPsAT X X -MAPK1 ERK2 P28482 human OLA1 67059 Q9CZ30 Ola1 mouse Y236 1880539204 VNLsEkDyIRKKNKW X -MAPK1 ERK2 P28482 human TTK 7272 P33981 TTK human S821 467281 GQLVGLNsPNsILkA X -MAPK1 ERK2 P28482 human NUP50 10762 Q9UKX7 NUP50 human S221 476622 kVAAEtQsPsLFGst X X -MAPK1 ERK2 P28482 human Kv4.2 16508 Q9Z0V2 Kcnd2 mouse T607 457612 IPtPPVttPEGDDRP X -MAPK1 ERK2 P28482 human STAT3 6774 P40763 STAT3 human S727 448191 NtIDLPMsPrTLDSL X 9134; 9136; 34911; 94994; 49081; 58978; 87544; 71958; 50804 -MAPK1 ERK2 P28482 human GRB10 2887 Q13322 GRB10 human S476 455870 MNILGsQsPLHPSTL X X 11817 -MAPK1 ERK2 P28482 human Tau iso8 4137 P10636-8 MAPT human S191 487448 ssGEPPKsGDRsGys X -MAPK1 ERK2 P28482 human FOXO3A 2309 O43524 FOXO3 human S425 2058400 TKGsGLGsPtSSFNS X X 64616 -MAPK1 ERK2 P28482 human PLA2G4A 5321 P47712 PLA2G4A human S505 447597 LNTSYPLsPLSDFAT PLA2_B X 2831; 53044 -MAPK1 ERK2 P28482 human HSP75 10131 Q12931 TRAP1 human S511 55374803 NrHLAEHsPyyEAMk HSP90 X -MAPK1 ERK2 P28482 human myocardin 214384 Q8VIM5 Myocd mouse S812 10791200 EVLLNSHsPIGKVSD X X -MAPK1 ERK2 P28482 human RAB3IP 29885 Q62739 Rab3ip rat S250 482771 VLSSsPTsPTQEPLA Sec2p X X -MAPK1 ERK2 P28482 human PR 18667 Q00175 Pgr mouse S294 447987 SPIAPGRsPLATTVV Prog_receptor X 13736 -MAPK1 ERK2 P28482 human OLA1 67059 Q9CZ30 Ola1 mouse T325 1880539200 AWTIRKGtKAPQAAG X X -MAPK1 ERK2 P28482 human CACNA1B 100008979 Q05152 CACNA1B rabbit S411 459047 DRNAEEKsPLDAVLK X -MAPK1 ERK2 P28482 human RBPMS 19663 Q9WVB0 Rbpms mouse T118 3208560 VGtPNPstPLPNTVP X X -MAPK1 ERK2 P28482 human MBP 618684 P02687 MBP cow T97 450929 KNIVtPRtPPPSQGK Myelin_MBP X -MAPK1 ERK2 P28482 human NPAS4 225872 Q8BGD7 Npas4 mouse T423 1871095704 LSKDLVCtPPYtPHQ X -MAPK1 ERK2 P28482 human LIN28A 83557 Q8K3Y3 Lin28a mouse S200 7231811 EEEEEIHsPALLPEA X -MAPK1 ERK2 P28482 human p300 2033 Q09472 EP300 human T317 486259 VQQPGLVtPVAQGMG X -MAPK1 ERK2 P28482 human SP1 6667 P08047 SP1 human T739 448227 sEGSGtAtPSALITT X X -MAPK1 ERK2 P28482 human hnRNP E2 5094 Q15366 PCBP2 human T213 482919 SASFPHTtPSMCLNP X X -MAPK1 ERK2 P28482 human ERK2 116590 P63086 Mapk1 rat T188 3949250 FLtEyVAtRWYRAPE Pkinase X -MAPK1 ERK2 P28482 human KHDRBS1 20218 Q60749 Khdrbs1 mouse T71 449877 PPLLPPStPGPDAtV X -MAPK1 ERK2 P28482 human dematin 2039 Q08495 DMTN human S96 1983773 KstsPPPsPEVWADs AbLIM_anchor X X -MAPK1 ERK2 P28482 human NCOA6 23054 Q14686 NCOA6 human S884 470103 NKDVTLTsPLLVNLL X -MAPK1 ERK2 P28482 human CK2A1 1457 P68400 CSNK2A1 human T360 449985 SGISSVPtPsPLGPL X X -MAPK1 ERK2 P28482 human TR-beta1 7068 P10828 THRB human S142 449635 IQKNLHPsYSCkYEG zf-C4 X X -MAPK1 ERK2 P28482 human STIM1 20866 P70302 Stim1 mouse S621 3635048 SHSLSPSsPDPDTPs X X -MAPK1 ERK2 P28482 human TH 25085 P04177 Th rat S8 448543 MPTPSAPsPQPKGFR TOH_N X -MAPK1 ERK2 P28482 human CITED2 10370 Q99967 CITED2 human T166 27145810 KHSGGSStPGGSGGS CITED X -MAPK1 ERK2 P28482 human MITF 4286 O75030 MITF human S180 450264 PGSSAPNsPMAMLTL MITF_TFEB_C_3_N X -MAPK1 ERK2 P28482 human CACNB1 50688 P54283 Cacnb1 rat S161 459045 CEVGFIPsPVKLDSL X -MAPK1 ERK2 P28482 human Ets-1 2113 P14921 ETS1 human T38 447950 CADVPLLtPSSkEMM X -MAPK1 ERK2 P28482 human PAP-alpha 18789 Q61183 Papola mouse S537 1737605 DNSMSVPsPTSAMKT X X -MAPK1 ERK2 P28482 human TH iso3 7054 P07101-3 TH human S31 448544 KQAEAIMsPRFIGRR TOH_N X -MAPK1 ERK2 P28482 human STIM1 6786 Q13586 STIM1 human S621 3635048 SRsHsPssPDPDtPs X -MAPK1 ERK2 P28482 human NPAS4 225872 Q8BGD7 Npas4 mouse S615 1871095701 GLLtPEAsPVKQSFF X -MAPK1 ERK2 P28482 human SMAD2 4087 Q15796 SMAD2 human S245 448794 NQsMDTGsPAELsPT X 3104 -MAPK1 ERK2 P28482 human NUP153 9972 P49790 NUP153 human T369 3191104 PPVQRLMtPKPVsIA Nup153 X -MAPK1 ERK2 P28482 human PRDX6 94167 O35244 Prdx6 rat T177 3823356 TASNPVAtPVDWKKG 1-cysPrx_C X -MAPK1 ERK2 P28482 human Bcl-6 604 P41182 BCL6 human S333 447600 KGLVsPQsPQKsDCQ X -MAPK1 ERK2 P28482 human SOS1 6654 Q07889 SOS1 human S1178 451315 IMSKHLDsPPAIPPR X -MAPK1 ERK2 P28482 human ER-beta 13983 O08537 Esr2 mouse S105 447914 LYAEPQKsPWCEARS ERbeta_N X -MAPK1 ERK2 P28482 human Abi-1 10006 Q8IZP0 ABI1 human S183 486178 PPtQKPPsPPMsGRG X X -MAPK1 ERK2 P28482 human SYN1 24949 P09951 Syn1 rat S67 451573 VAsPAAPsPGSSGGG X -MAPK1 ERK2 P28482 human ELK1 13712 P41969 Elk1 mouse S384 447872 IHFWSTLsPIAPRsP X 9181; 9186 -MAPK1 ERK2 P28482 human p21Cip1 1026 P38936 CDKN1A human S98 478193 GGRRPGTsPALLQGT X -MAPK1 ERK2 P28482 human CTNND1 1500 O60716 CTNND1 human T310 450457 GtARRtGtPsDPRRR X -MAPK1 ERK2 P28482 human ERK5 5598 Q13164 MAPK7 human T733 455520 LPPVFsGtPKGSGAG X -MAPK1 ERK2 P28482 human Abi-1 10006 Q8IZP0 ABI1 human S225 1983922 ARLGsQHsPGRtAsL X X -MAPK1 ERK2 P28482 human Kv4.2 16508 Q9Z0V2 Kcnd2 mouse S616 457613 EGDDRPEsPEYsGGN X -MAPK1 ERK2 P28482 human DUSP5 1847 Q16690 DUSP5 human T321 10206802 ESEILPStPNPQPPS X -MAPK1 ERK2 P28482 human p300 2033 Q09472 EP300 human S2366 486264 MEQGHFAsPDQNSML X X -MAPK1 ERK2 P28482 human Kir6.2 16514 Q61743 Kcnj11 mouse T341 2103600 GNTIKVPtPLCTARQ IRK_C X -MAPK1 ERK2 P28482 human YTHDF2 51441 Q9Y5A9 YTHDF2 human S39 483929 DDFEPyLsPQARPNN X -MAPK1 ERK2 P28482 human Kv4.2 16508 Q9Z0V2 Kcnd2 mouse T602 457611 TAIISIPtPPVttPE X -MAPK1 ERK2 P28482 human TNF-R1 21937 P25118 Tnfrsf1a mouse T296 25573803 FSsPVSStPIsPIFG X -MAPK1 ERK2 P28482 human SMAD1 4086 Q15797 SMAD1 human S214 451176 PTSSDPGsPFQMPAD X -MAPK1 ERK2 P28482 human SMAD3 4088 P84022 SMAD3 human T179 451177 PQSNIPEtPPPGYLS X -MAPK1 ERK2 P28482 human NEUROD1 18012 Q60867 Neurod1 mouse S259 465678 ALEPFFEsPLTDCTs Neuro_bHLH X -MAPK1 ERK2 P28482 human NEUROD1 18012 Q60867 Neurod1 mouse S274 465680 PSFDGPLsPPLSING Neuro_bHLH X -MAPK1 ERK2 P28482 human SMAD3 4088 P84022 SMAD3 human S213 451180 NLsPNPMsPAHNNLD X -MAPK1 ERK2 P28482 human p300 2033 Q09472 EP300 human T938 486260 LLPPQPAtPLSQPAV X -MAPK1 ERK2 P28482 human SHC4 399694 Q6S5L8 SHC4 human T159 1868546600 GHRATALtPDSCPLP X X -MAPK1 ERK2 P28482 human PML iso4 5371 P29590-4 PML human S530 451473 DGPPsPRsPVIGsEV DUF3583 X X -MAPK1 ERK2 P28482 human SREBP-2 6721 Q12772 SREBF2 human S432 451007 NQNVLLMsPPASDSG X X -MAPK1 ERK2 P28482 human CENPE 1062 Q02224 CENPE human S2608 459189 tCENsPKsPKVtGTA X -MAPK1 ERK2 P28482 human GLE1 2733 Q53GS7 GLE1 human T102 472369 FsPAsPAtPNGTKGk X -MAPK1 ERK2 P28482 human SRC-2 10499 Q15596 NCOA2 human S736 465446 tIkQEPVsPkkKENA DUF4927 X -MAPK1 ERK2 P28482 human TNF-R1 21937 P25118 Tnfrsf1a mouse T286 25573801 NPTLGFStPGFSsPV X -MAPK1 ERK2 P28482 human NEUROD1 18012 Q60867 Neurod1 mouse S266 465679 sPLTDCTsPSFDGPL Neuro_bHLH X -MAPK1 ERK2 P28482 human SREBP-1 6720 P36956 SREBF1 human S117 469986 YPSMPAFsPGPGIkE X X -MAPK1 ERK2 P28482 human FOXO3A 2309 O43524 FOXO3 human S12 9318037 PAsPAPLsPLEVELD X -MAPK1 ERK2 P28482 human GLRA1 14654 Q64018 Glra1 mouse S408 1869137000 PPPAPSKsPEEMRkL X X -MAPK1 ERK2 P28482 human GAB1 2549 Q13480 GAB1 human T476 451274 EANyVPMtPGTFDFS X -MAPK1 ERK2 P28482 human Abi-1 10006 Q8IZP0 ABI1 human S267 18715503 PIAVPtPsPPTIGPE X -MAPK1 ERK2 P28482 human myocardin 214384 Q8VIM5 Myocd mouse S859 10791202 ELLPGPLsPMHAQLs X X -MAPK1 ERK2 P28482 human KSR 16706 Q61097 Ksr1 mouse S443 449300 TTSSTPSsPAPFLTS X -MAPK1 ERK2 P28482 human N-Myc 4613 P04198 MYCN human S62 448222 LLPtPPLsPsrGFAE Myc_N X -MAPK1 ERK2 P28482 human PARP1 142 P09874 PARP1 human T373 463805 AAtPPPstAsAPAAV X -MAPK1 ERK2 P28482 human AML1 iso8 861 Q01196-8 RUNX1 human S303 454401 VHPAtPIsPGRASGM X -MAPK1 ERK2 P28482 human NHE1 6548 P19634 SLC9A1 human S693 468293 VPAHKLDsPtMsRAR NEXCaM_BD X -MAPK1 ERK2 P28482 human NHE1 6548 P19634 SLC9A1 human S770 475073 MMRsKETssPGtDDV X -MAPK1 ERK2 P28482 human Bcl-2 596 P10415 BCL2 human S87 448396 AAAGPALsPVPPVVH X X -MAPK1 ERK2 P28482 human p27Kip1 1027 P46527 CDKN1B human T187 447875 NAGsVEQtPKKPGLR X -MAPK1 ERK2 P28482 human RBM17 84991 Q96I25 RBM17 human T71 470694 DDrQIVDtPPHVAAG X X -MAPK1 ERK2 P28482 human Tau iso8 4137 P10636-8 MAPT human S46 447926 tDAGLkEsPLQtPtE X 20296 -MAPK1 ERK2 P28482 human NFAT3 4776 Q14934 NFATC4 human S676 455348 SNGRRKRsPTQSFRF RHD_dimer X X -MAPK1 ERK2 P28482 human MCR 4306 P08235 NR3C2 human S361 25692903 TLRDVVPsPDTQEKG X -MAPK1 ERK2 P28482 human MBP 4155 P02686 MBP human T232 450929 KNIVTPRtPPPSQGK Myelin_MBP X -MAPK1 ERK2 P28482 human JMJD2B 23030 O94953 KDM4B human S566 452590 PTWkEPVsPMELTGP X -MAPK1 ERK2 P28482 human p70S6K 83840 P67999 Rps6kb1 rat S441 450015 sPRRFIGsPRtPVsP X -MAPK1 ERK2 P28482 human NHE1 6548 P19634 SLC9A1 human T779 3914103 PGtDDVFtPAPsDsP X -MAPK1 ERK2 P28482 human TOP2A 7153 P11388 TOP2A human S1361 455094 sPPKTKtsPKLsNkE X -MAPK1 ERK2 P28482 human PITPNM1 9600 O00562 PITPNM1 human T794 451456 LEMLVPStPTSTSGA DDHD X -MAPK1 ERK2 P28482 human HER2 2064 P04626 ERBB2 human T701 472481 TELVEPLtPsGAMPN X -MAPK1 ERK2 P28482 human SREBP-1 iso3 6720 P36956-3 SREBF1 human T81 36533415 SPPQPAPtPLKMYPS X -MAPK1 ERK2 P28482 human smMLCK 100009143 P29294 MYLK rabbit S1005 455821 GLSGRKSsTGSPTsP X -MAPK1 ERK2 P28482 human 4E-BP1 1978 Q13541 EIF4EBP1 human S65 447527 FLMECrNsPVtktPP eIF_4EBP X 9451; 9456; 13443 -MAPK1 ERK2 P28482 human C/EBP-alpha 1050 P49715 CEBPA human S21 448308 PMsSHLQsPPHAPSS X X 2841 -MAPK1 ERK2 P28482 human NOX5 iso4 79400 Q96PH1-4 NOX5 human S498 472626 RSVtMRKsQRSsKGS FAD_binding_8 X -MAPK1 ERK2 P28482 human ERF 2077 P50548 ERF human T526 448321 GEAGGPLtPRRVssD X X -MAPK1 ERK2 P28482 human DUSP6 67603 Q9DBB1 Dusp6 mouse S159 455265 DGSCSSSsPPLPVLG X -MAPK1 ERK2 P28482 human NUP153 9972 P49790 NUP153 human S516 3191083 TNKVQMtsPsstGsP Nup153 X -MAPK1 ERK2 P28482 human RAB3IP 29885 Q62739 Rab3ip rat S247 2023489 KTLVLSSsPTsPTQE Sec2p X X -MAPK1 ERK2 P28482 human RSK2 110651 P18654 Rps6ka3 mouse S227 448063 DHEKKAysFCGtVEy Pkinase X 3556 -MAPK1 ERK2 P28482 human RBPMS 19663 Q9WVB0 Rbpms mouse T12 6054914 GKAEkENtPsEANLQ X -MAPK1 ERK2 P28482 human Tau iso8 4137 P10636-8 MAPT human S202 447928 sGyssPGsPGtPGsR X 39357; 30505 -MAPK1 ERK2 P28482 human DUSP5 1847 Q16690 DUSP5 human S376 10206801 TVSELSRsPVATATS X -MAPK1 ERK2 P28482 human Snail1 6615 O95863 SNAI1 human S104 455881 GkGsQPPsPPsPAPs X X -MAPK1 ERK2 P28482 human NUP153 9972 P49790 NUP153 human S257 3191077 ktsQLGDsPFyPGkT Nup153 X -MAPK1 ERK2 P28482 human PKM 5315 P14618 PKM human S37 476070 MCRLDIDsPPItARN X X -MAPK1 ERK2 P28482 human METTL3 56339 Q86U44 METTL3 human S43 483736 rNPEAALsPTFRsDs X -MAPK1 ERK2 P28482 human PXN iso2 5829 P49023-2 PXN human S130 450228 KQKsAEPsPtVMSts Paxillin X -MAPK1 ERK2 P28482 human p300 2033 Q09472 EP300 human S2315 486263 RsPQPVPsPrPQsQP X X -MAPK1 ERK2 P28482 human RIMS1 84556 Q9JIR4 Rims1 rat S447 2761601 ARVsPPEsPRARAAA X -MAPK1 ERK2 P28482 human CITED2 17684 O35740 Cited2 mouse T166 27145810 KHSGGSStPGGAGGS CITED X -MAPK1 ERK2 P28482 human HIF2A 2034 Q99814 EPAS1 human S672 56668652 APLGPPVsPPHVSTF X X -MAPK1 ERK2 P28482 human STIM1 20866 P70302 Stim1 mouse S575 468876 LVEKLPDsPALAKKT X X -MAPK1 ERK2 P28482 human p21Cip1 1026 P38936 CDKN1A human S130 455618 sGEQAEGsPGGPGDs X X -MAPK1 ERK2 P28482 human CDC73 79577 Q6P1J9 CDC73 human S465 1879768900 PWLLPDGsPVDIFAK X -MAPK1 ERK2 P28482 human FRA2 2355 P15408 FOSL2 human S320 4707550 QSSDsLNsPtLLAL_ X -MAPK1 ERK2 P28482 human BAD 572 Q92934 BAD human S75 447860 EIRsRHssyPAGtED Bcl-2_BAD X 9291; 5284; 9296; 5193; 11865; 94223 -MAPK1 ERK2 P28482 human NDEL1 81565 Q9GZM8 NDEL1 human T245 3211851 GFGtsPLtPSARISA NUDE_C X -MAPK1 ERK2 P28482 human CITED2 10370 Q99967 CITED2 human S85 27145811 VNGGHPPsALAPAAR CITED X -MAPK1 ERK2 P28482 human RXRA 6256 P19793 RXRA human S260 450891 NMGLNPssPNDPVtN Hormone_recep X X -MAPK1 ERK2 P28482 human NUP153 9972 P49790 NUP153 human S338 468337 IVssPLNsPLDrsGI Nup153 X -MAPK1 ERK2 P28482 human Snail2 6591 O43623 SNAI2 human S87 25525400 SSSLGRVsPPPPsDT X X -MAPK1 ERK2 P28482 human BIK 12124 O70337 Bik mouse T116 25171001 IWSWRVLtPGAWVSP bcl-2I13 X -MAPK1 ERK2 P28482 human SRm300 75956 Q8BTI8 Srrm2 mouse S1068 453278 GsLsRsssPVtELtA X X -MAPK1 ERK2 P28482 human eIF4G iso8 1981 Q04637-8 EIF4G1 human S1232 449798 EAALPPVsPLKAALs X X -MAPK1 ERK2 P28482 human RAB3IP 29885 Q62739 Rab3ip rat S19 37039803 VNLAsPTsPDLLGVC X X -MAPK1 ERK2 P28482 human CENPE 1062 Q02224 CENPE human S2639 459190 QDPVPKEsPkSCFFD X -MAPK1 ERK2 P28482 human KLF4 16600 Q60793 Klf4 mouse S132 24976100 ASASSSSsPASSGPA X -MAPK1 ERK2 P28482 human PLCB1 23236 Q9NQ66 PLCB1 human S982 4787475 KkKsEPssPDHGssT X X -MAPK1 ERK2 P28482 human TRF2 7014 Q15554 TERF2 human S365 452842 PTQALPAsPALKNKR X X -MAPK1 ERK2 P28482 human NHE1 6548 P19634 SLC9A1 human S771 475074 MRsKETssPGtDDVF X -MAPK1 ERK2 P28482 human CAPN2 824 P17655 CAPN2 human S50 451162 GTLFQDPsFPAIPSA Peptidase_C2 X -MAPK1 ERK2 P28482 human NHE1 6548 P19634 SLC9A1 human S723 2509103 VItIDPAsPQsPEsV X -MAPK1 ERK2 P28482 human PRDX6 9588 P30041 PRDX6 human T177 3823356 TAEKRVAtPVDWkDG 1-cysPrx_C X -MAPK1 ERK2 P28482 human ER-alpha 2099 P03372 ESR1 human S118 448101 LHPPPQLsPFLQPHG Oest_recep X X 2511 -MAPK1 ERK2 P28482 human 4E-BP1 116636 Q62622 Eif4ebp1 rat T45 447496 GGtLFSttPGGtRII eIF_4EBP X 2855; 9459; 2846; 5123; 3929; 7547; 45613; 39788 -MAPK1 ERK2 P28482 human MKL1 57591 Q969V6 MRTFA human S454 467355 tGstPPVsPtPsERS X -MAPK1 ERK2 P28482 human SOS1 6654 Q07889 SOS1 human S1197 451317 kAYsPrysISDRTSI X -MAPK1 ERK2 P28482 human DAZAP1 26528 Q96EP5 DAZAP1 human T315 467205 GVPPPPAtPGAAPLA X -MAPK1 ERK2 P28482 human GRB10 2887 Q13322 GRB10 human S150 454185 PELCGPGsPPVLtPG X X -MAPK1 ERK2 P28482 human supervillin Q6U1J6 SVIL ferret S132 7721700 DSEADSEsPSRYTKS X X -MAPK1 ERK2 P28482 human NIPA 232679 Q80YV2 Zc3hc1 mouse S358 483339 tRsWEsssPVDRPEL X -MAPK1 ERK2 P28482 human NHE1 6548 P19634 SLC9A1 human S785 1983418 FtPAPsDsPssQRIQ X -MAPK1 ERK2 P28482 human METTL3 56339 Q86U44 METTL3 human S525 1871246003 YGMIERLsPGTRKIE MT-A70 X -MAPK1 ERK2 P28482 human SMAD3 4088 P84022 SMAD3 human S208 451179 DAGsPNLsPNPMsPA X -MAPK1 ERK2 P28482 human RSK2 6197 P51812 RPS6KA3 human Y529 464205 TITKTVEyLHAQGVV Pkinase X -MAPK1 ERK2 P28482 human NUP153 9972 P49790 NUP153 human S320 4747698 QsLEkMssPLADAkR Nup153 X -MAPK1 ERK2 P28482 human MBP 618684 P02687 MBP cow T94 455362 HFFKNIVtPRtPPPS Myelin_MBP X -MAPK1 ERK2 P28482 human ER-alpha 2099 P03372 ESR1 human S106 448100 PLNsVsPsPLMLLHP Oest_recep X X -MAPK1 ERK2 P28482 human ADD2 119 P35612 ADD2 human S600 481589 PAksAPAsPVQsPAK X X -MAPK1 ERK2 P28482 human JMJD2B 23030 O94953 KDM4B human S352 4957088 tRPTALTsPELSSWS X -MAPK1 ERK2 P28482 human SOS1 6654 Q07889 SOS1 human S1193 451316 QPTSkAYsPrysISD X -MAPK1 ERK2 P28482 human 5-LO 240 P09917 ALOX5 human S664 461913 QLPYYYLsPDRIPNs X 3749 -MAPK1 ERK2 P28482 human JMJD2B 23030 O94953 KDM4B human T1065 479896 AKRPRVGtPLAtEDS X -MAPK1 ERK2 P28482 human E2A iso2 6929 P15923-2 TCF3 human S352 465681 SSNNFSSsPStPVGs X -MAPK1 ERK2 P28482 human capicua 23152 Q96RK0 CIC human S1409 453485 sAPEDPtsPKRKMRR X -MAPK1 ERK2 P28482 human p47phox 653361 P14598 NCF1 human S345 451727 QARPGPQsPGsPLEE X -MAPK1 ERK2 P28482 human mGluR5 108071 Q3UVX5 Grm5 mouse S1158 25581600 LVALtPPsPFRDSVD GluR_Homer-bdg X -MAPK1 ERK2 P28482 human WTAP 9589 Q15007 WTAP human T148 36131377 ELSAWkFtPDSQTGK Wtap X -MAPK1 ERK2 P28482 human PIMT 96764 Q96RS0 TGS1 human S298 3636737 DLVsFPssPIMVDND X X -MAPK1 ERK2 P28482 human p70S6K 83840 P67999 Rps6kb1 rat S434 448356 SFEPKIRsPRRFIGs X -MAPK1 ERK2 P28482 human Oct4 5460 Q01860 POU5F1 human S111 25236703 EsNsDGAsPEPCtVt X X -MAPK1 ERK2 P28482 human Cofilin-1 12631 P18760 Cfl1 mouse T25 7990494 MkVRKSstPEEVKkR Cofilin_ADF X -MAPK1 ERK2 P28482 human TTP 22695 P22893 Zfp36 mouse S220 457797 PPGDLPLsPSAFSAA X -MAPK1 ERK2 P28482 human RBPMS 19663 Q9WVB0 Rbpms mouse S144 34503161 VPALYPSsPEVWAPY X -MAPK1 ERK2 P28482 human Mnk1 8569 Q9BUB5 MKNK1 human T255 447622 ITtPELTtPCGSAEY Pkinase X 2111; 43507 -MAPK1 ERK2 P28482 human DUSP6 67603 Q9DBB1 Dusp6 mouse S197 455266 SATDSDGsPLSNSQP X -MAPK1 ERK2 P28482 human TOB1 10140 P50616 TOB1 human S152 455535 PASSVSSsPsPPFGH X X -MAPK1 ERK2 P28482 human ADD1 118 P35611 ADD1 human S669 6421811 EEAHRPPsPtEAPTE X X -MAPK1 ERK2 P28482 human Tau iso8 4137 P10636-8 MAPT human T217 449078 sRtPsLPtPPtREPK X 33134; 51625 -MAPK1 ERK2 P28482 human CDCA5 113130 Q96FF9 CDCA5 human S209 3208965 DMtLPGIsPPPEKQK Sororin X -MAPK1 ERK2 P28482 human 53BP2 7159 Q13625 TP53BP2 human S827 30995203 NSDMPAPsPGLDYEP X -MAPK1 ERK2 P28482 human NR2C1 22025 Q505F1 Nr2c1 mouse T210 4206803 sPLAAtPtFVTDSET X -MAPK1 ERK2 P28482 human MAPKAPK2 9261 P49137 MAPKAPK2 human S9 449763 LSNSQGQsPPVPFPA X -MAPK1 ERK2 P28482 human RPS3 6188 P23396 RPS3 human T42 455909 sGVEVRVtPTRtEII KH_2 X X -MAPK1 ERK2 P28482 human BIM 64547 O88498 Bcl2l11 rat S65 449330 GPLAPPAsPGPFATR X 4581; 4585 -MAPK1 ERK2 P28482 human AKAP4 8852 Q5JQC9 AKAP4 human T265 457176 KERISPRtPAsKIAs AKAP_110 X X -MAPK1 ERK2 P28482 human PXN 360820 Q66H76 Pxn rat S130 450228 KQKsAEPsPtVMSss Paxillin X X -MAPK1 ERK2 P28482 human MDM2 4193 Q00987 MDM2 human S166 448130 SsRRRAIsEtEENsD X 3521 -MAPK1 ERK2 P28482 human MSK1 73086 Q8C050 Rps6ka5 mouse T764 471413 LssNPLMtPDILGSS X -MAPK1 ERK2 P28482 human RBPMS 19663 Q9WVB0 Rbpms mouse S14 14579056 AEkENtPsEANLQEE X -MAPK1 ERK2 P28482 human TWIST1 7291 Q15672 TWIST1 human S68 18905000 GGGDEPGsPAQGkRG X X -MAPK1 ERK2 P28482 human CTNND1 1500 O60716 CTNND1 human T308 3651652 DyGtARRtGtPsDPR X -MAPK1 ERK2 P28482 human MAPKAPK2 9261 P49137 MAPKAPK2 human T222 448269 tSHNsLttPCytPYY Pkinase X 3316 -MAPK1 ERK2 P28482 human DCC 25311 Q63155 Dcc rat T1187 26395103 IQSCQDLtPVSHSQS Neogenin_C X -MAPK1 ERK2 P28482 human separase 9700 Q14674 ESPL1 human S1126 447673 IAPStNSsPVLKTKP X -MAPK1 ERK2 P28482 human Tau iso8 4137 P10636-8 MAPT human T50 447931 LkEsPLQtPtEDGsE X -MAPK1 ERK2 P28482 human AML1 iso8 861 Q01196-8 RUNX1 human S462 454402 AEGSHSNsPTNMAPS RunxI X -MAPK1 ERK2 P28482 human MED1 5469 Q15648 MED1 human T1457 449866 HsKsPAytPQNLDsE X X -MAPK1 ERK2 P28482 human ARHGEF2 9181 Q92974 ARHGEF2 human T679 449343 PGVELLLtPREPALP X -MAPK1 ERK2 P28482 human Fos 314322 P12841 Fos rat T325 448483 TELEPLCtPVVTCtP X -MAPK1 ERK2 P28482 human TPPP 11076 O94811 TPPP human S160 487536 GVtKAIssPtVSRLT p25-alpha X -MAPK1 ERK2 P28482 human MSK1 9252 O75582 RPS6KA5 human S360 448215 TEMDPTYsPAALPQS Pkinase_C X 9594 -MAPK1 ERK2 P28482 human DCP1A 75901 Q91YD3 Dcp1a mouse S339 3213297 LPLsPVLsPTLPAEA X -MAPK1 ERK2 P28482 human NPAS4 225872 Q8BGD7 Npas4 mouse T611 1871095703 LVPEGLLtPEAsPVK X -MAPK1 ERK2 P28482 human CBX7 52609 Q8VDS3 Cbx7 mouse T119 29669800 TNGPPPWtPTLPSSE CBX7_C X -MAPK1 ERK2 P28482 human PSD-93 1740 Q15700 DLG2 human S323 472024 KtsLPPIsPGRySPI PDZ_assoc X -MAPK1 ERK2 P28482 human 4E-BP1 1978 Q13541 EIF4EBP1 human T70 447528 rNsPVtktPPRDLPt eIF_4EBP X 9455; 13396 -MAPK1 ERK2 P28482 human SPHK2 56848 Q9NRA0 SPHK2 human S387 477181 PATVEPAsPTPAHSL X X -MAPK1 ERK2 P28482 human PBK 55872 Q96KB5 PBK human S32 471715 PtINIPAsPFMQKLG X X -MAPK1 ERK2 P28482 human HePTP 5778 P35236 PTPN7 human T66 448311 EPICsVNtPREVTLH X -MAPK1 ERK2 P28482 human Jun 3725 P05412 JUN human S73 447943 VGLLkLAsPELERLI Jun X X 9164; 3270; 8752; 12714; 77955 -MAPK1 ERK2 P28482 human Snail2 6591 O43623 SNAI2 human S104 25603909 KDHsGSEsPISDEEE X -MAPK1 ERK2 P28482 human SREBP-1 iso3 6720 P36956-3 SREBF1 human S93 469986 YPSMPAFsPGPGIKE X -MAPK1 ERK2 P28482 human MEK1 5604 Q02750 MAP2K1 human T286 448286 VEGdAAEtPPRPRtP Pkinase X 9127 -MAPK1 ERK2 P28482 human TXNIP 10628 Q9H3M7 TXNIP human T349 3212307 HRLEsPttPLLDDMD X X -MAPK1 ERK2 P28482 human NCAM-L1 3897 P32004 L1CAM human S1248 472277 NDssGAtsPINPAVA X -MAPK1 ERK2 P28482 human HIF1A 3091 Q16665 HIF1A human S643 470106 kILIAsPsPTHIHkE X -MAPK1 ERK2 P28482 human FBXW7 55294 Q969H0 FBXW7 human S176 25126709 KRKLDHGsEVRSFSL X -MAPK1 ERK2 P28482 human SMAD3 4088 P84022 SMAD3 human S204 451178 NHSMDAGsPNLsPNP X -MAPK1 ERK2 P28482 human RBPMS 19663 Q9WVB0 Rbpms mouse T187 1880754300 WIPPSEAtSQGWkSR X -MAPK1 ERK2 P28482 human PDE4D iso4 5144 Q08499-4 PDE4D human S490 451090 YQSTIPQsPSPAPDD X X -MAPK1 ERK2 P28482 human girdin 55704 Q3V6T2 CCDC88A human S233 4725929 HASSSAQsPCGsPGM X -MAPK1 ERK2 P28482 human CITED2 10370 Q99967 CITED2 human T175 27145812 GGSGGSStPGGSGSS CITED X -MAPK1 ERK2 P28482 human HSF4 3299 Q9ULV5 HSF4 human S298 4037600 LLkEEPAsPGGDGEA X X -MAPK1 ERK2 P28482 human DYRK1B 9149 Q9Y463 DYRK1B human S421 50269512 YEPAARIsPLGALQH Pkinase X -MAPK1 ERK2 P28482 human SOX10 6663 P56693 SOX10 human T244 628303300 GPPtPPTtPkTELQS X X -MAPK1 ERK2 P28482 human FRA2 14284 P47930 Fosl2 mouse S320 4707550 QSSDSLNsPtLLAL_ X -MAPK1 ERK2 P28482 human METTL3 56339 Q86U44 METTL3 human S50 3204585 sPTFRsDsPVPtAPt X -MAPK1 ERK2 P28482 human USP11 8237 P51784 USP11 human S948 466974 GssGAPAsPACssPP X -MAPK1 ERK2 P28482 human Abi-1 10006 Q8IZP0 ABI1 human T394 12626406 ENIADsPtPPPPPPP X -MAPK1 ERK2 P28482 human FAM195B 348262 C9JLW8 MCRIP1 human S21 486127 kRtssPRsPPsSsEI FAM195 X X -MAPK1 ERK2 P28482 human DCC 25311 Q63155 Dcc rat S1267 26395104 QyPGILPsPTCGYPH Neogenin_C X -MAPK1 ERK2 P28482 human NUP153 9972 P49790 NUP153 human S529 452707 sPMFKFSsPIVKsTE Nup153 X X -MAPK1 ERK2 P28482 human CEP55 55165 Q53EZ4 CEP55 human S425 457628 NREKVAAsPksPtAA X -MAPK1 ERK2 P28482 human Snail1 6615 O95863 SNAI1 human S82 11493501 ASLRLQEsPRVAELT X X -MAPK1 ERK2 P28482 human 4E-BP1 116636 Q62622 Eif4ebp1 rat T36 447497 PPGDYsttPGGtLFS eIF_4EBP X 2855; 9459; 2846; 5123; 3929; 7547; 45613; 39788 -MAPK1 ERK2 P28482 human GTF2I iso2 2969 P78347-2 GTF2I human S627 452349 INTKALQsPKRPRsP X -MAPK1 ERK2 P28482 human CASP8 841 Q14790 CASP8 human S387 16855100 yLEMDLSsPQTRYIP Peptidase_C14 X X -MAPK1 ERK2 P28482 human Bcl-2 12043 P10417 Bcl2 mouse S70 448395 RDMAARtsPLRPLVA X X -MAPK1 ERK2 P28482 human PTPRCAP 5790 Q14761 PTPRCAP human S163 4733815 EGDLVLGsPGPASAG PTPRCAP X -MAPK1 ERK2 P28482 human dematin 2039 Q08495 DMTN human S90 481650 ERsLSPKstsPPPsP AbLIM_anchor X X -MAPK1 ERK2 P28482 human ERK2 5594 P28482 MAPK1 human S246 6845001 HILGILGsPsQEDLN Pkinase X X -MAPK1 ERK2 P28482 human Stargazin 84347 Q71RJ2 Cacng2 rat T321 451273 NTANRRTtPV_____ X -MAPK1 ERK2 P28482 human Tau 29477 P19332 Mapt rat T516 447933 ssPGsPGtPGsRSRt X 25377; 43964; 53001; 49561; 20060; 33032; 30505; 20739; 98160 -MAPK1 ERK2 P28482 human JMJD2B 23030 O94953 KDM4B human S622 452591 LGRPPTRsPLsVVKQ X -MAPK1 ERK2 P28482 human RORA iso4 6095 P35398-4 RORA human T128 482887 PGEAEPLtPTYNISA X -MAPK1 ERK2 P28482 human Raptor 57521 Q8N122 RPTOR human S863 453732 LtQsAPAsPtNkGVH X X -MAPK1 ERK2 P28482 human STAT5A 6776 P42229 STAT5A human S780 448750 DsLDsRLsPPAGLFT X X -MAPK1 ERK2 P28482 human MCL1 17210 P97287 Mcl1 mouse T144 455375 ADGsLPStPPPPEEE X 4579 -MAPK1 ERK2 P28482 human Tau iso8 4137 P10636-8 MAPT human T181 447932 ktPPAPktPPssGEP X X 12885; 66224; 62672 -MAPK1 ERK2 P28482 human JunD 24518 P52909 Jund rat S100 456168 LGLLKLAsPELERLI Jun X 9164 -MAPK1 ERK2 P28482 human ELK1 13712 P41969 Elk1 mouse T418 452139 ISVDGLStPVVLsPG X -MAPK1 ERK2 P28482 human MCR 4306 P08235 NR3C2 human S287 4767239 SVKsPVSsPNNVTLR X -MAPK1 ERK2 P28482 human STF-1 26423 P33242 Nr5a1 mouse S203 447603 EYPEPYAsPPQQPGP X X -MAPK1 ERK2 P28482 human DRP1 10059 O00429 DNM1L human S616 454690 PIPIMPAsPQKGHAV X X 3455; 4494; 63940 -MAPK1 ERK2 P28482 human Oct4 5460 Q01860 POU5F1 human S355 25236701 VSVTtLGsPMHsN__ X -MAPK1 ERK2 P28482 human RIMS1 84556 Q9JIR4 Rims1 rat S745 2023137 ISVIsPTsPGALKDA X -MAPK1 ERK2 P28482 human DNMT3A Q4W5Z4 DNMT3A chicken S220 4700048 QQPTDPAsPNVATTP X -MAPK1 ERK2 P28482 human REST 5978 Q13127 REST human S864 453739 TEDLsPPsPPLPKEN X X -MAPK1 ERK2 P28482 human gephyrin 64845 Q03555 Gphn rat S281 483463 AsLSttPsEsPRAQA X -MAPK1 ERK2 P28482 human HECTD3 79654 Q5T447 HECTD3 human T157 150180307 ARLVPIDtPNHLQRQ X -MAPK1 ERK2 P28482 human EGFR 1956 P00533 EGFR human T693 448054 RELVEPLtPsGEAPN X X 3056; 8808 -MAPK1 ERK2 P28482 human NHE1 24782 P26431 Slc9a1 rat S775 475073 MIRsKEPssPGTDDV X -MAPK1 ERK2 P28482 human MAPKAPK5 8550 Q8IW41 MAPKAPK5 human T182 450093 IDQGDLMtPQFtPyY Pkinase X -MAPK1 ERK2 P28482 human girdin 55704 Q3V6T2 CCDC88A human S237 4725935 SAQsPCGsPGMKRTE X -MAPK1 ERK2 P28482 human MARCKS 4082 P29966 MARCKS human S46 454165 VKVNGDAsPAAAEsG MARCKS X -MAPK1 ERK2 P28482 human ATF-2 11909 P16951 Atf2 mouse T53 448225 IVADQtPtPtRFLKN X 9225; 9221; 5112; 94125; 13850; 40749; 15411; 24329; 61584; 27934; 92109; 20534; 35858 -MAPK1 ERK2 P28482 human Jun 3725 P05412 JUN human S63 447686 kNsDLLtsPDVGLLk Jun X X 5464; 9261; 2361; 97721; 91952 -MAPK1 ERK2 P28482 human NHE1 24782 P26431 Slc9a1 rat S776 475074 IRsKEPssPGTDDVF X -MAPK1 ERK2 P28482 human PML iso4 5371 P29590-4 PML human S38 451470 EGRQPsPsPsPTERA X X -MAPK1 ERK2 P28482 human CDK2 1017 P24941 CDK2 human T160 447739 GVPVRtytHEVVtLW Pkinase X 2561 -MAPK1 ERK2 P28482 human FOXO3A 2309 O43524 FOXO3 human S344 2058401 QDDDAPLsPMLYSSS X X -MAPK1 ERK2 P28482 human TNF-R1 21937 P25118 Tnfrsf1a mouse S269 451128 KPLtPAPsPAFsPTS X -MAPK1 ERK2 P28482 human PTP-PEST 5782 Q05209 PTPN12 human S571 1983755 KtVsLtPsPtTQVEt X X -MAPK1 ERK2 P28482 human SHOC2 8036 Q9UQ13 SHOC2 human T507 1867945200 GLGENLLtHLPEEIG LRR_8 X -MAPK1 ERK2 P28482 human Abi-1 10006 Q8IZP0 ABI1 human S392 12626405 VQENIADsPtPPPPP X -MAPK1 ERK2 P28482 human TNF-R1 21937 P25118 Tnfrsf1a mouse T265 450966 EKAGKPLtPAPsPAF X -MAPK1 ERK2 P28482 human GLRA1 2741 P23415 GLRA1 human S408 1869137000 PPPAPSKsPEEMRKL X X -MAPK1 ERK2 P28482 human MCL1 4170 Q07820 MCL1 human T163 455375 tDGsLPstPPPAEEE X X 4579; 14765 -MAPK1 ERK2 P28482 human smMLCK 396445 P11799 MYLK chicken S1768 468782 AsGssPTsPINADKV X -MAPK1 ERK2 P28482 human IRS1 3667 P35568 IRS1 human S639 447507 yMPMsPKsVSAPQQI X 2388 -MAPK1 ERK2 P28482 human myocardin 214384 Q8VIM5 Myocd mouse T893 10791203 TMEWLDLtPPSSTPG X X -MAPK1 ERK2 P28482 human 4E-BP1 1978 Q13541 EIF4EBP1 human T37 447497 PPGDysttPGGtLFs eIF_4EBP X 2855; 9459; 2846; 5123; 3929; 7547; 45613; 39788 -MAPK1 ERK2 P28482 human Tau iso8 4137 P10636-8 MAPT human T175 449077 AtRIPAktPPAPktP X -MAPK1 ERK2 P28482 human RAMAC 83640 Q9BTL3 RAMAC human S36 3210933 yLKRPPEsPPIVEEW RAM X X -MAPK1 ERK2 P28482 human Abi-1 10006 Q8IZP0 ABI1 human S216 3205884 VPNDyMtsPARLGsQ X -MAPK1 ERK2 P28482 human Abi-1 10006 Q8IZP0 ABI1 human T265 18715504 GIPIAVPtPsPPTIG X -MAPK1 ERK2 P28482 human CACNA1B 100008979 Q05152 CACNA1B rabbit S447 459048 TGLCAPGsPFARASL X -MAPK1 ERK2 P28482 human MCR 4306 P08235 NR3C2 human S238 25692902 QGTPLTCsPNVENRG X -MAPK1 ERK2 P28482 human Ets-1 23871 P27577 Ets1 mouse T38 447950 CADVPLLtPSsKEMM X -MAPK1 ERK2 P28482 human DAZAP1 26528 Q96EP5 DAZAP1 human T269 467204 FTSYIVStPPGGFPP X -MAPK1 ERK2 P28482 human BMF 90427 Q96LC9 BMF human S74 11267001 DKATQTLsPAsPSQG BMF X X -MAPK1 ERK2 P28482 human p70S6K 6198 P23443 RPS6KB1 human T444 448358 RFIGsPRtPVsPVkF X 9204 -MAPK1 ERK2 P28482 human TOP2A 7153 P11388 TOP2A human S1354 452240 DFVPsDAsPPKTKts X -MAPK1 ERK2 P28482 human RBPMS 19663 Q9WVB0 Rbpms mouse S117 5815926 LVGtPNPstPLPNTV X -MAPK1 ERK2 P28482 human p70S6K 6198 P23443 RPS6KB1 human S434 448356 sFEPKIRsPRRFIGs X -MAPK1 ERK2 P28482 human ADD1 118 P35611 ADD1 human S707 13310034 GAAADPGsDGsPGKs X X -MAPK1 ERK2 P28482 human Myc 4609 P01106 MYC human S77 448586 LLPtPPLsPsRRsGL Myc_N X X 13748 -MAPK1 ERK2 P28482 human CEP55 55165 Q53EZ4 CEP55 human S428 457629 KVAAsPksPtAALNE X -MAPK1 ERK2 P28482 human IL2RB 3560 P14784 IL2RB human T476 41591300 PQPLGPPtPGVPDLV X -MAPK1 ERK2 P28482 human p90RSK 81771 Q63531 Rps6ka1 rat T573 447993 AENGLLMtPCYTANF Pkinase X 9346 -MAPK1 ERK2 P28482 human hnRNP E2 5094 Q15366 PCBP2 human S173 482916 MLETLSQsPPKGVtI X X -MAPK1 ERK2 P28482 human ELK1 13712 P41969 Elk1 mouse T364 22725902 LLPTHTLtPVLLtPS X -MAPK1 ERK2 P28482 human STMN1 16765 P54227 Stmn1 mouse S25 448555 QAFELILsPRskEsV Stathmin X -MAPK1 ERK2 P28482 human C/EBP-beta 12608 P28033 Cebpb mouse T188 447878 sSssPPGtPSPADAK X 3084 -MAPK1 ERK2 P28482 human PGK1 5230 P00558 PGK1 human S203 468410 yFAkALEsPERPFLA PGK X -MAPK1 ERK2 P28482 human GRASP55 26003 Q9H8Y8 GORASP2 human T225 470123 QMAGtPItPLKDGFT X -MAPK1 ERK2 P28482 human MED1 5469 Q15648 MED1 human T1032 458308 SSSNRPFtPPTsTGG X -MAPK1 ERK2 P28482 human ARRB2 409 P32121 ARRB2 human T276 50247604 FCKVYTItPLLSDNR Arrestin_C X -MAPK1 ERK2 P28482 human p27Kip1 1027 P46527 CDKN1B human S10 447874 NVRVSNGsPsLErMD X -MAPK1 ERK2 P28482 human Securin 30939 Q9CQJ7 Pttg1 mouse S162 452603 LLHLGPPsPLKTPFL Securin X X -MAPK1 ERK2 P28482 human DCC 25311 Q63155 Dcc rat S1178 4711110 TDPAGRGsPIQSCQD Neogenin_C X -MAPK1 ERK2 P28482 human ARHGAP26 396113 Q5ZMW5 ARHGAP26 chicken S686 452134 PMFSAPSsPMPTSST X X -MAPK1 ERK2 P28482 human PDX1 3651 P52945 PDX1 human S61 458401 LGALEQGsPPDIsPY X -MAPK1 ERK2 P28482 human GATA4 54254 P46152 Gata4 rat S105 449604 AYTPPPVsPRFSFPG GATA-N X -MAPK1 ERK2 P28482 human PARVA 55742 Q9NVD7 PARVA human S8 4270099 MAtsPQKsPsVPKsP X -MAPK1 ERK2 P28482 human Tau iso8 4137 P10636-8 MAPT human T212 447934 tPGsRsRtPsLPtPP X -MAPK1 ERK2 P28482 human IP3R1 16438 P11881 Itpr1 mouse S1765 469627 sFGNGPLsPGGPSkP X -MAPK1 ERK2 P28482 human MAFA 389692 Q8NHW3 MAFA human S65 5403102 PCSsVPSsPSFCAPS X X -MAPK1 ERK2 P28482 human PML iso4 5371 P29590-4 PML human S36 451469 PSEGRQPsPsPsPTE X X -MAPK1 ERK2 P28482 human ERG 2078 P11308 ERG human S96 4712353 kGGkMVGsPDTVGMN X X -MAPK1 ERK2 P28482 human p27Kip1 1027 P46527 CDKN1B human S178 450208 EENVsDGsPNAGsVE X -MAPK1 ERK2 P28482 human ERF 2077 P50548 ERF human S161 456969 sPtEDPRsPPACssS X X -MAPK1 ERK2 P28482 human CCNB1 891 P14635 CCNB1 human S128 448815 LVDTAsPsPMETsGC X -MAPK1 ERK2 P28482 human MAPKAPK2 9261 P49137 MAPKAPK2 human T25 448271 APPPQPPtPALPHPP X -MAPK1 ERK2 P28482 human GLI1 2735 P08151 GLI1 human S130 1877717204 HLSIGTMsPSLGFPA X -MAPK1 ERK2 P28482 human EEF2K 25435 P70531 Eef2k rat S358 447826 GTEEKCGsPRIRTLs X -MAPK1 ERK2 P28482 human Raptor 57521 Q8N122 RPTOR human S8 17538200 MESEMLQsPLLGLGE X X -MAPK1 ERK2 P28482 human Nur77 3164 P22736 NR4A1 human S431 21697917 IPGFAELsPADQDLL Hormone_recep X -MAPK1 ERK2 P28482 human CAD 790 P27708 CAD human T456 451248 KVYFLPItPHYVTQV X X -MAPK1 ERK2 P28482 human SP1 6667 P08047 SP1 human T453 448226 SGPIIIRtPTVGPNG X X -MAPK1 ERK2 P28482 human ERF 2077 P50548 ERF human S251 456968 PLsPFPVsPLAGPGS X X -MAPK1 ERK2 P28482 human HSF1 3297 Q00613 HSF1 human S326 455484 ssVDtLLsPTALIDs Vert_HS_TF X -MAPK1 ERK2 P28482 human FBXW7 55294 Q969H0 FBXW7 human T205 25585000 GLVPCSAtPTTFGDL X -MAPK1 ERK2 P28482 human TAB1 10454 Q15750 TAB1 human S438 456224 tPTLTNQsPTLtLQS X -MAPK1 ERK2 P28482 human NUP153 9972 P49790 NUP153 human S334 468336 RIPsIVssPLNsPLD Nup153 X -MAPK1 ERK2 P28482 human SOS1 6654 Q07889 SOS1 human S1132 451313 TLPHGPRsAsVssIS X -MAPK1 ERK2 P28482 human HDAC6 10013 Q9UBN7 HDAC6 human T1031 29604202 ASStDHQtPPtsPVQ X -MAPK1 ERK2 P28482 human MAPKAPK2 9261 P49137 MAPKAPK2 human T334 448273 QstKVPQtPLHtsRV X 3007; 3041 -MAPK1 ERK2 P28482 human BRAF 396239 Q04982 BRAF chicken T793 460657 YACAsPKtPIQAGGY X X -MAPK1 ERK2 P28482 human NUP214 8021 P35658 NUP214 human S1710 10296402 VSSSGFSsPAFGTTA X -MAPK1 ERK2 P28482 human Cortactin 2017 Q14247 CTTN human S418 447701 tEErLPssPVyEDAA X X -MAPK1 ERK2 P28482 human MSK1 9252 O75582 RPS6KA5 human T581 448217 PDNQPLKtPCFTLHY Pkinase X 9595 -MAPK1 ERK2 P28482 human NOXA1 10811 Q86UR1 NOXA1 human S282 12570900 VGKQAPLsPGLPAMG X X -MAPK1 ERK2 P28482 human BANP 54971 Q8N9N5 BANP human T352 41301701 PSEPMMStPPPASEL X -MAPK1 ERK2 P28482 human Bcl-2 596 P10415 BCL2 human T56 448655 FSSQPGHtPHPAASR X 2875 -MAPK1 ERK2 P28482 human NUP153 9972 P49790 NUP153 human T413 10296400 TGYEkNMtPGQNREQ Nup153 X -MAPK1 ERK2 P28482 human hnRNP E2 5094 Q15366 PCBP2 human S189 482917 yRPkPsssPVIFAGG X X -MAPK1 ERK2 P28482 human p70S6K 83840 P67999 Rps6kb1 rat T444 448358 RFIGsPRtPVsPVKF X 9204 -MAPK1 ERK2 P28482 human Kv4.2 Q63881 Kcnd2 rat T607 457612 IPtPPVTtPEGDDRP X -MAPK1 ERK2 P28482 human KIBRA 23286 Q8IX03 WWC1 human S542 25673102 sPRSsLSsPSPPCsP X -MAPK1 ERK2 P28482 human ELK1 2002 P19419 ELK1 human S383 447872 IHFWSTLsPIAPRsP X X 9181; 9186 -MAPK1 ERK2 P28482 human RAB3IP 29885 Q62739 Rab3ip rat S16 37039802 FHEVNLAsPTsPDLL X X -MAPK1 ERK2 P28482 human GATA6 2627 Q92908 GATA6 human S266 2833503 VSARFPYsPsPPMAN GATA-N X -MAPK1 ERK2 P28482 human TH 25085 P04177 Th rat S31 448544 KQAEAVtsPRFIGRR TOH_N X 3370; 13041 -MAPK1 ERK2 P28482 human p53 7157 P04637 TP53 human S15 447490 PsVEPPLsQEtFsDL P53_TAD X X 4030; 9235; 9284; 9286; 8695; 8514; 82530; 56979 -MAPK1 ERK2 P28482 human KLC1 16593 O88447 Klc1 mouse S459 477826 YKACKVDsPtVtttL X X -MAPK1 ERK2 P28482 human COPS6 10980 Q7L5N1 COPS6 human S148 48903200 QVCEIIEsPLFLkLN JAB X -MAPK1 ERK2 P28482 human GLE1 2733 Q53GS7 GLE1 human S93 31084897 PKsPDAssAFsPAsP X -MAPK1 ERK2 P28482 human TOB1 10140 P50616 TOB1 human S164 455537 FGHSAAVsPTFMPRS X X -MAPK1 ERK2 P28482 human PML iso4 5371 P29590-4 PML human S40 451471 RQPsPsPsPTERAPA X X -MAPK1 ERK2 P28482 human GLI1 2735 P08151 GLI1 human S102 41595602 LQTVIRTsPSSLVAF X -MAPK1 ERK2 P28482 human ADD2 119 P35612 ADD2 human S596 3147633 EPGsPAksAPAsPVQ X X -MAPK1 ERK2 P28482 human GAB2 9846 Q9UQC2 GAB2 human S623 454021 ALDFQPssPsPHRKP X -MAPK1 ERK2 P28482 human 4E-BP1 1978 Q13541 EIF4EBP1 human T46 447496 GGtLFsttPGGtRII eIF_4EBP X 2855; 9459; 2846; 4923; 5123; 3929; 7547; 45613; 39788 -MAPK1 ERK2 P28482 human GRASP65 56082 O35254 Gorasp1 rat S277 455582 EQLPGPGsPGHGTAD X X -MAPK1 ERK2 P28482 human RSK2 6197 P51812 RPS6KA3 human Y488 464203 DVyDDGKyVYVVTEL Pkinase X -MAPK1 ERK2 P28482 human SH2-B-beta 25970 Q9NRF2 SH2B1 human S96 457414 PPILAPLsPGAEIsP X -MAPK1 ERK2 P28482 human HIF1A 3091 Q16665 HIF1A human S641 470105 DIkILIAsPsPTHIH X -MAPK1 ERK2 P28482 human DAPK1 1612 P53355 DAPK1 human S734 454887 NsSRFPPsPLASKPT X X -MAPK1 ERK2 P28482 human myocardin 214384 Q8VIM5 Myocd mouse S866 10791201 sPMHAQLsPPSVDSS X X -MAPK1 ERK2 P28482 human RSK2 110651 P18654 Rps6ka3 mouse S386 448065 HQLFRGFsFVAITSD Pkinase_C X 9341; 9335; 13575; 11989; 12032; 75266; 93317; 13397; 13588 -MAPK1 ERK2 P28482 human CENPE 1062 Q02224 CENPE human S2605 459188 KQVtCENsPKsPKVt X -MAPK1 ERK2 P28482 human AML1 iso8 861 Q01196-8 RUNX1 human S293 454400 QYLGSIAsPSVHPAt X -MAPK1 ERK2 P28482 human 4E-BP1 116636 Q62622 Eif4ebp1 rat S82 447525 PTIPGVTsPTSDEPP eIF_4EBP X -MAPK1 ERK2 P28482 human PDE4B iso2 5142 Q07343-2 PDE4B human S487 471380 YQSMIPQsPSPPLDE X -MAPK1 ERK2 P28482 human GLE1 2733 Q53GS7 GLE1 human S92 50831365 VPKsPDAssAFsPAs X -MAPK1 ERK2 P28482 human Tau iso8 4137 P10636-8 MAPT human T205 447933 ssPGsPGtPGsRsRt X 25377; 43964; 53001; 49561; 20060; 33032; 30505; 20739; 98160 -MAPK1 ERK2 P28482 human MEK1 5604 Q02750 MAP2K1 human T386 448288 IGLNQPstPtHAAGV X -MAPK1 ERK2 P28482 human TOP2A 7153 P11388 TOP2A human S1393 452242 GsVPLsssPPAtHFP X -MAPK1 ERK2 P28482 human DDHD1 338047 O46606 DDHD1 cow S730 465585 TIPSPVTsPVLSRRH DDHD X -MAPK1 ERK2 P28482 human E2A iso2 6929 P15923-2 TCF3 human T355 455166 NFSSsPStPVGsPQG X -MAPK1 ERK2 P28482 human MSK1 73086 Q8C050 Rps6ka5 mouse T645 448217 PDNQPLKtPCFTLHY Pkinase X 9595 -MAPK1 ERK2 P28482 human JMJD2B 23030 O94953 KDM4B human T305 484516 IDYGkVAtQCTCRKD X -MAPK1 ERK2 P28482 human EWS 2130 Q01844 EWSR1 human T79 7359501 QPPTGYTtPTAPQAY X X -MAPK1 ERK2 P28482 human SOX10 6663 P56693 SOX10 human T240 56655880 GQSHGPPtPPTtPkT X X -MAPK1 ERK2 P28482 human LIN28A 79727 Q9H9Z2 LIN28A human S200 7231811 EEEEEIHsPtLLPEA X 20607 -MAPK1 ERK2 P28482 human ERF 2077 P50548 ERF human S246 456967 RGGPEPLsPFPVsPL X X -MAPK1 ERK2 P28482 human Tau iso8 4137 P10636-8 MAPT human S422 449083 GsIDMVDsPQLAtLA X -MAPK1 ERK2 P28482 human BMF 90427 Q96LC9 BMF human S77 22999100 TQTLsPAsPSQGVML BMF X X -MAPK1 ERK2 P28482 human KHDRBS1 20218 Q60749 Khdrbs1 mouse S58 449876 PrGGArAsPAtQPPP X X -MAPK1 ERK2 P28482 human NUP153 9972 P49790 NUP153 human S522 3191092 tsPsstGsPMFKFSs Nup153 X -MAPK1 ERK2 P28482 human p300 2033 Q09472 EP300 human S2039 31828207 GLGQVGIsPLKPGTV Creb_binding X -MAPK1 ERK2 P28482 human Tau iso8 4137 P10636-8 MAPT human S235 449080 VVRtPPKsPssAKsR X 20473 -MAPK1 ERK2 P28482 human YTHDF2 51441 Q9Y5A9 YTHDF2 human T381 6223825 SQAGSGstPsEPHPV X -MAPK1 ERK2 P28482 human GLE1 2733 Q53GS7 GLE1 human S88 12667856 QPSFVPKsPDAssAF X -MAPK1 ERK2 P28482 human SREBP-2 6721 Q12772 SREBF2 human S455 451008 SIDSEPGsPLLDDAK X X -MAPK1 ERK2 P28482 human NR0B2 23957 Q62227 Nr0b2 mouse S26 7596703 TILYALLsPSPRTRP X X -MAPK1 ERK2 P28482 human NPAS4 225872 Q8BGD7 Npas4 mouse S577 1871095700 LYEKLPPsPSsPGNG X -MAPK1 ERK2 P28482 human K8 3856 P05787 KRT8 human S432 448540 sAyGGLtsPGLsysL X -MAPK1 ERK2 P28482 human PR 5241 P06401 PGR human S294 447987 APMAPGRsPLATTVM Prog_receptor X X 13736 -MAPK1 ERK2 P28482 human ADD1 118 P35611 ADD1 human S355 456832 kYKAKsRsPGsPVGE X X -MAPK1 ERK2 P28482 human PSD-95 29495 P31016 Dlg4 rat S290 469608 PtAMtPTsPRRYsPV PDZ_assoc X -MAPK1 ERK2 P28482 human p21Cip1 1026 P38936 CDKN1A human T57 451222 NFDFVtEtPLEGDFA CDI X X -MAPK1 ERK2 P28482 human SMAD2 4087 Q15796 SMAD2 human T220 448793 QSNYIPEtPPPGYIS X -MAPK1 ERK2 P28482 human p300 2033 Q09472 EP300 human S1038 10941006 STSATQssPAPGQsk X -MAPK1 ERK2 P28482 human TOP2A 7153 P11388 TOP2A human S1213 452237 QMAEVLPsPRGQRVI X -MAPK1 ERK2 P28482 human Jun 24516 P17325 Jun rat S246 450451 PGETPPLsPIDMESQ X 2994 -MAPK1 ERK2 P28482 human p53 7157 P04637 TP53 human T55 450685 DDIEQWFtEDPGPDE TAD2 X X -MAPK1 ERK2 P28482 human IEX-1 8870 P46695 IER3 human T18 455559 MTILQAPtPAPSTIP X X -MAPK1 ERK2 P28482 human C/EBP-beta 1051 P17676 CEBPB human T235 447878 SsssPPGtPSPADAK X X 3084 -MAPK1 ERK2 P28482 human DCP1A 75901 Q91YD3 Dcp1a mouse S335 3213294 PsYTLPLsPVLsPTL X -MAPK1 ERK2 P28482 human Bcl-6 604 P41182 BCL6 human S343 471422 KsDCQPNsPTESCSS X -MAPK1 ERK2 P28482 human eIF2-alpha 1965 P05198 EIF2S1 human S52 447635 MILLsELsRRRIRsI S1 X 3597; 9721; 3398; 5199; 53085; 95797 -MAPK1 ERK2 P28482 human Kv4.2 Q63881 Kcnd2 rat T602 457611 TAIISIPtPPVTtPE X -MAPK1 ERK2 P28482 human vinexin iso2 10174 O60504-2 SORBS3 human S188 452554 DGPQLPTsPRLTAAA X X -MAPK1 ERK2 P28482 human KHDRBS1 20218 Q60749 Khdrbs1 mouse T84 449878 tVVGSAPtPLLPPSA X -MAPK1 ERK2 P28482 human AML3 iso5 12393 Q08775-5 Runx2 mouse S319 10892802 SYLSQMTsPSIHSTt X -MAPK1 ERK2 P28482 human CDCA5 113130 Q96FF9 CDCA5 human S79 470691 AVQsPRRsPRIsFFL X -MAPK1 ERK2 P28482 human ADD2 119 P35612 ADD2 human S592 481588 tAPEEPGsPAksAPA X X -MAPK1 ERK2 P28482 human ERG 2078 P11308 ERG human S215 9429097 VDKALQNsPRLMHAR X X -MAPK1 ERK2 P28482 human DUSP1 1843 P28562 DUSP1 human S296 457717 kQRRSIIsPNFSFMG DSPc X X -MAPK1 ERK2 P28482 human 4E-BP1 116636 Q62622 Eif4ebp1 rat T69 447528 RNsPVAKtPPKDLPT eIF_4EBP X 9455 -MAPK1 ERK2 P28482 human p300 328572 B2RWS6 Ep300 mouse S2364 486264 MEQGHFAsPDQNSML X X -MAPK1 ERK2 P28482 human SOS1 6654 Q07889 SOS1 human S1167 451314 EsAPAEssPsKIMSK X -MAPK1 ERK2 P28482 human HIF2A 2034 Q99814 EPAS1 human S484 1876807202 SSCSTPNsPEDYYTS X -MAPK1 ERK2 P28482 human AR 367 P10275 AR human S516 452166 VSRVPYPsPTCVkSE X -MAPK1 ERK2 P28482 human p300 328572 B2RWS6 Ep300 mouse S2312 486263 RsPQPVPsPRPQsQP X X -MAPK1 ERK2 P28482 human STF-1 2516 Q13285 NR5A1 human S203 447603 EYPEPYAsPPQPGLP X -MAPK1 ERK2 P28482 human NANOG 79923 Q9H9S0 NANOG human S65 31960311 MDLLIQDsPDsStsP X -MAPK1 ERK2 P28482 human EXOC7 23265 Q9UPT5 EXOC7 human S250 483909 sSSGVPysPAIPNKR X X -MAPK1 ERK2 P28482 human TH 21823 P24529 Th mouse S31 448544 KQAEAVtsPRFIGRR TOH_N X 3370; 13041 -CDK14 CDK14 O94921 human LRP6 4040 O75581 LRP6 human S1490 456289 AILNPPPsPAtERsH X 2568 -CDK14 CDK14 O94921 human CBCP1 219771 Q8ND76 CCNY human S73 3850500 stIFLsksQtDVREK X X -CDK14 CDK14 O94921 human CBCP1 219771 Q8ND76 CCNY human S71 4750438 RAstIFLsksQtDVR X X -CDK14 CDK14 O94921 human CBCP1 219771 Q8ND76 CCNY human S83 4750444 DVREKRKsLFINHHP X -CDK14 CDK14 O94921 human PPP1R2 5504 P41236 PPP1R2 human S87 449054 GDDEDACsDtEAtEA IPP-2 X -CDK14 CDK14 O94921 human LRP6 16974 O88572 Lrp6 mouse S1490 456289 AILNPPPsPAtERSH X 2568 -CDK14 CDK14 O94921 human CBCP1 219771 Q8ND76 CCNY human S295 31000122 sFPLEPLsRERAHkL X -CDK14 CDK14 O94921 human CBCP1 219771 Q8ND76 CCNY human S288 31000119 LAEANNLsFPLEPLs X -CDK14 CDK14 O94921 human TAGLN2 8407 P37802 TAGLN2 human S83 19083400 PVkkIQAstMAFkQM CH X -CDK14 CDK14 O94921 human CBCP1 219771 Q8ND76 CCNY human T67 20651051 SDHPRAstIFLsksQ X -CDK14 CDK14 O94921 human TAGLN2 8407 P37802 TAGLN2 human S163 468770 kENPRNFsDNQLQEG X -Pak4 PAK4 Q8BTW9 mouse PPAR-gamma 19016 P37238 Pparg mouse S273 15175800 TGkTTDKsPFVIYDM X -Pak4 PAK4 Q8BTW9 mouse MRLC2 67938 Q3THE2 Myl12b mouse S20 448595 KRPQRAtsNVFAMFD X -GSK3B GSK3B iso2 P49841-2 human MAP1B 17755 P14873 Map1b mouse S1260 454136 sLsPsPPsPIEKtPL X X -GSK3B GSK3B iso2 P49841-2 human GSK3B iso2 2932 P49841-2 GSK3B human Y216 448569 RGEPNVSyICSRYYR Pkinase X -GSK3A GSK3A P49840 human PPAR-alpha 5465 Q07869 PPARA human S280 1867858200 FHCCQCTsVETVTEL Hormone_recep X -GSK3A GSK3A P49840 human Tau iso8 4137 P10636-8 MAPT human T231 449079 KKVAVVRtPPKsPss X 20473; 71429 -GSK3A GSK3A P49840 human GRB14 2888 Q14449 GRB14 human S362 31834912 QGRsGCSsQSIsPMR X X -GSK3A GSK3A P49840 human Tau iso8 4137 P10636-8 MAPT human S199 447927 GDRsGyssPGsPGtP X 29957 -GSK3A GSK3A P49840 human LRP6 4040 O75581 LRP6 human S1544 21009101 CDSDyAPsRRMtSVA X -GSK3A GSK3A P49840 human IRF3 3661 Q14653 IRF3 human T180 28095000 sPsLDNPtPFPNLGP X -GSK3A GSK3A P49840 human MAFA 389692 Q8NHW3 MAFA human S61 1320401 PLStPCSsVPSsPSF X -GSK3A GSK3A P49840 human NBR1 4077 Q14596 NBR1 human T586 33602700 HNtPVDVtPCMsPLP X X -GSK3A GSK3A P49840 human NFM 24588 P12839 Nefm rat S507 448042 VEKsPVKsPEAKEEE X -GSK3A GSK3A P49840 human SMAD2 Q1W668 SMAD2 cow S245 448794 NQSMDTGsPAELsPT X -GSK3A GSK3A P49840 human C/EBP-alpha 12606 P53566 Cebpa mouse T222 449824 HLQPGHPtPPPtPVP X X 2844 -GSK3A GSK3A P49840 human FBXL20 84961 Q96IG2 FBXL20 human T417 467016 HAYFAPVtPPPsVGG X X -GSK3A GSK3A P49840 human GSK3A 2931 P49840 GSK3A human Y279 447723 RGEPNVsyICsRyyR Pkinase X -GSK3A GSK3A P49840 human STAT2 6773 P52630 STAT2 human S393 1869778702 LtPEKGQsQGLIWDF STAT_bind X X -GSK3A GSK3A P49840 human TBX21 57765 Q9JKD8 Tbx21 mouse S508 458229 PsSGDSSsPAGAPsP X -GSK3A GSK3A P49840 human desmin 1674 P17661 DES human S32 466343 PLGsPLssPVFPrAG Filament_head X -GSK3A GSK3A P49840 human CTNNB1 1499 P35222 CTNNB1 human S37 447582 yLDsGIHsGATtTAP X 9561; 2009; 4270; 13537; 41334; 60180 -GSK3A GSK3A P49840 human FBXL20 84961 Q96IG2 FBXL20 human S251 1875005604 RGCHKLQsLCAsGCS X X -GSK3A GSK3A P49840 human Tau iso8 4137 P10636-8 MAPT human S396 449081 GAEIVyKsPVVsGDt X 9632 -GSK3A GSK3A P49840 human FBXL20 84961 Q96IG2 FBXL20 human S255 1875005606 KLQsLCAsGCSNITD X X -GSK3A GSK3A P49840 human IL17RA 16172 Q60943 Il17ra mouse T779 41452470 EVVLEGCtPSEEEQR X -GSK3A GSK3A P49840 human NDRG1 10397 Q92597 NDRG1 human S362 454250 HtsEGtRsRsHtsEG X -GSK3A GSK3A P49840 human C/EBP-alpha 12606 P53566 Cebpa mouse T226 449825 GHPtPPPtPVPsPHA X X 2844 -GSK3A GSK3A P49840 human Tau iso8 4137 P10636-8 MAPT human S404 449082 PVVsGDtsPRHLsNV X 35834; 20194; 98523; 91600; 49562 -GSK3A GSK3A P49840 human MITF iso9 4286 O75030-9 MITF human S298 448503 QARAHGLsLIPSTGL DUF3371 X -GSK3A GSK3A P49840 human MAFA 389692 Q8NHW3 MAFA human T57 456028 LSStPLStPCSsVPS X -GSK3A GSK3A P49840 human CdGAP 12549 A6X8Z5 Arhgap31 mouse T776 456517 tPAPPPPtPLEEEPE X X -GSK3A GSK3A P49840 human Tau iso8 4137 P10636-8 MAPT human S262 447930 NVKskIGstENLkHQ Tubulin-binding X -GSK3A GSK3A P49840 human LRP6 4040 O75581 LRP6 human S1490 456289 AILNPPPsPAtERsH X 2568 -GSK3A GSK3A P49840 human MAFA 389692 Q8NHW3 MAFA human S49 1320400 CHRLPPGsLSStPLS X -GSK3A GSK3A P49840 human RICTOR 253260 Q6R327 RICTOR human T1695 40638601 EAEAVLAtPPKQPIV X -GSK3A GSK3A P49840 human FBXL20 84961 Q96IG2 FBXL20 human S139 1875005600 DATCTSLskFCsKLR X X -GSK3A GSK3A P49840 human Myc 4609 P01106 MYC human T73 448496 kkFELLPtPPLsPsR Myc_N X 46650 -GSK3A GSK3A P49840 human NIFK 84365 Q9BYG3 NIFK human S230 457632 tPEKtVDsQGPtPVC hNIFK_binding X -GSK3A GSK3A P49840 human STAT3 6774 P40763 STAT3 human S727 448191 NtIDLPMsPrTLDSL X 9134; 9136; 34911; 94994; 49081; 58978; 87544; 71958; 50804 -GSK3A GSK3A P49840 human desmin 1674 P17661 DES human S28 4705787 APGFPLGsPLssPVF Filament_head X -GSK3A GSK3A P49840 human desmin Q5XFN2 DES dog S32 466343 PLGsPLGsPVFPRAG Filament_head X -GSK3A GSK3A P49840 human PD-L1 29126 Q9NZQ7 CD274 human S279 1872811800 CGIQDTNsKkQsDtH X X -GSK3A GSK3A P49840 human FBXL20 84961 Q96IG2 FBXL20 human S425 4149424 PPPsVGGsRQRFCRC X X -GSK3A GSK3A P49840 human Bcl-xL 598 Q07817 BCL2L1 human S62 449099 PSWHLADsPAVNGAT X -GSK3A GSK3A P49840 human OSBP2 23762 Q969R2 OSBP2 human S762 11171320 ECSKVMHssPssPsS Oxysterol_BP X -GSK3A GSK3A P49840 human UNG 7374 P13051 UNG human S64 2018601 EPGtPPssPLsAEQL X -GSK3A GSK3A P49840 human GPSM3 63940 Q9Y4H4 GPSM3 human S35 4717965 STTRPWRsAPPsPPP X -GSK3A GSK3A P49840 human SMAD2 Q1W668 SMAD2 cow T220 448793 QSNYIPEtPPPGYIS X -GSK3A GSK3A P49840 human STMN3 50861 Q9NZ72 STMN3 human S60 4698871 sFEVILksPSDLsPE Stathmin X -GSK3A GSK3A P49840 human OSBP2 23762 Q969R2 OSBP2 human S766 15721694 VMHssPssPsSDGKQ Oxysterol_BP X -GSK3A GSK3A P49840 human UNG 7374 P13051 UNG human T60 452622 AGQEEPGtPPssPLs X -GSK3A GSK3A P49840 human FBXL20 84961 Q96IG2 FBXL20 human S143 1875005602 TSLskFCsKLRHLDL LRR_6 X X -GSK3A GSK3A P49840 human STAT3 6774 P40763 STAT3 human T714 3190177 ktKFICVtPTtCsNt X -GSK3A GSK3A P49840 human STAT2 6773 P52630 STAT2 human T385 1869778701 ILTsNQktLtPEKGQ STAT_bind X X -GSK3A GSK3A P49840 human CRMP-2 1808 Q16555 DPYSL2 human S518 448081 ktVtPAssAktsPAk X -GSK3A GSK3A P49840 human IRF3 3661 Q14653 IRF3 human S123 4712212 DFSQPDTsPDTNGGG X -GSK3A GSK3A P49840 human CRMP-2 25416 P47942 Dpysl2 rat T514 454386 SVtPKTVtPASsAKT X 9397 -GSK3A GSK3A P49840 human MAFA 389692 Q8NHW3 MAFA human T53 1320402 PPGsLSStPLStPCS X -GSK3A GSK3A P49840 human AMPKA1 5562 Q13131 PRKAA1 human T490 3195170 EAksGtAtPQRsGsV AdenylateSensor X -GSK3A GSK3A P49840 human SMAD2 Q1W668 SMAD2 cow S255 448796 ELsPTTLsPVNHSLD X -GSK3A GSK3A P49840 human EEF2K 25435 P70531 Eef2k rat S391 4696253 MSDVTFDsLPSsPSS X -GSK3A GSK3A P49840 human CRMP-2 25416 P47942 Dpysl2 rat S522 448082 PASsAKTsPAKQQAP X -GSK3A GSK3A P49840 human PD-L1 29126 Q9NZQ7 CD274 human S283 14735979 DTNsKkQsDtHLEEt X -GSK3A GSK3A P49840 human STAT2 6773 P52630 STAT2 human S381 1869778700 RkFNILTsNQktLtP STAT_bind X X -GSK3A GSK3A P49840 human desmin Q5XFN2 DES dog S28 4705787 AGGFPLGsPLGsPVF Filament_head X -GSK3A GSK3A P49840 human GRB14 2888 Q14449 GRB14 human S358 31834913 MHPYQGRsGCSsQSI X X -GSK3A GSK3A P49840 human neurogenin 2 11924 P70447 Neurog2 mouse S231 2255101 SPYSCTLsPAsPGSD X -GSK3A GSK3A P49840 human Bcl-3 602 P20749 BCL3 human S402 3627521 LSASPSSsPSQsPPR X -GSK3A GSK3A P49840 human GRB14 2888 Q14449 GRB14 human S423 62887802 THGsPtAsSQSSATN X X -GSK3A GSK3A P49840 human NFM 24588 P12839 Nefm rat S503 448041 EEPEVEKsPVKsPEA X -GSK3A GSK3A P49840 human IL17RA 23765 Q96F46 IL17RA human T780 41452470 MVLTDPHtPYEEEQR X -GSK3A GSK3A P49840 human SRC-3 8202 Q9Y6Q9 NCOA3 human S509 482840 GVHsPMAsSGNTGNH NCOA_u2 X -GSK3A GSK3A P49840 human NFM 24588 P12839 Nefm rat S604 451836 EKPEKAKsPVPKsPV X -GSK3A GSK3A P49840 human Aiolos 22806 Q9UKT9 IKZF3 human S378 4696322 VPSERGLsPNNSGHD X -GSK3A GSK3A P49840 human PKAR2A 518399 P00515 PRKAR2A cow S48 466004 REARsRAsTPPAAPP X -GSK3A GSK3A P49840 human NDRG1 10397 Q92597 NDRG1 human S342 454248 tsLDGtRsRsHtsEG X -GSK3A GSK3A P49840 human CRMP-2 12934 O08553 Dpysl2 mouse T514 454386 sVtPktVtPAssAkt X 9397 -GSK3A GSK3A P49840 human Bcl-3 602 P20749 BCL3 human S406 3627522 PSSsPSQsPPRDPPG X -GSK3A GSK3A P49840 human PKAR2A 518399 P00515 PRKAR2A cow S45 466003 TRLREARsRAsTPPA RIIa X -GSK3A GSK3A P49840 human DYN2 13430 P39054 Dnm2 mouse S848 3059607 GIPPGVPsRRAPAAP X X -GSK3A GSK3A P49840 human neurogenin 2 11924 P70447 Neurog2 mouse S234 2255100 SCTLsPAsPGSDVDy X -GSK3A GSK3A P49840 human GRB14 2888 Q14449 GRB14 human S419 24986639 LRLGTHGsPtAsSQS X X -GSK3A GSK3A P49840 human CCNE1 898 P24864 CCNE1 human T395 447676 PLPSGLLtPPQsGKK X -GSK3A GSK3A P49840 human OSBP2 23762 Q969R2 OSBP2 human S768 15721697 HssPssPsSDGKQKT Oxysterol_BP X -GSK3A GSK3A P49840 human CTNND1 311163 D3ZZZ9 Ctnnd1 rat T310 450457 GTARRTGtPSDPRRR X -GSK3A GSK3A P49840 human GR 24413 P06536 Nr3c1 rat T171 451795 TSATGCAtPTEKEFP GCR X -GSK3A GSK3A P49840 human CRMP-2 25416 P47942 Dpysl2 rat S518 448081 KTVtPASsAKTsPAK X -GSK3A GSK3A P49840 human LRP6 4040 O75581 LRP6 human S1607 21241903 HLYPPPPsPCTDss_ X -GSK3A GSK3A P49840 human CTNNB1 1499 P35222 CTNNB1 human S33 447487 QQQsyLDsGIHsGAT X 9561; 2009; 4270; 13537; 41334; 60180 -GSK3A GSK3A P49840 human LRP6 4040 O75581 LRP6 human T1572 3802448 EPVPPPPtPRsQyLs X -GSK3A GSK3A P49840 human OSBP2 23762 Q969R2 OSBP2 human S763 31727226 CSKVMHssPssPsSD Oxysterol_BP X -GSK3A GSK3A P49840 human NFM 24588 P12839 Nefm rat S667 448045 PDKKKAEsPVKEKAV X -GSK3A GSK3A P49840 human CTNNB1 1499 P35222 CTNNB1 human T41 447583 GIHsGATtTAPsLsG X 9561; 9565; 4270; 13537; 41334; 60180 -GSK3A GSK3A P49840 human SMAD2 Q1W668 SMAD2 cow S250 448795 TGsPAELsPTTLsPV X -GSK3A GSK3A P49840 human NDRG1 10397 Q92597 NDRG1 human S352 454249 HtsEGtRsRsHtsEG X -GSK3A GSK3A P49840 human PKD2 5311 Q13563 PKD2 human S76 460685 AGAAAsPsPPLsSCS X X -GSK3A GSK3A P49840 human IRS2 384783 P81122 Irs2 mouse S484 1308919 RPSSGSAsASGsPSD X -GSK3A GSK3A P49840 human PI4K2A 84095 Q2TBE6 Pi4k2a mouse S5 2022753 ___MDETsPLVsPER X -GSK3A GSK3A P49840 human PI4K2A 84095 Q2TBE6 Pi4k2a mouse S47 468434 AAAGsGPsPPCsPGH X -GSK3A GSK3A P49840 human ANKRD28 23243 O15084 ANKRD28 human S1007 459224 INRyTNTskTVsFEA X -GSK3A GSK3A P49840 human NIFK 84365 Q9BYG3 NIFK human T234 449332 tVDsQGPtPVCtPtF hNIFK_binding X -GSK3A GSK3A P49840 human FBXL20 84961 Q96IG2 FBXL20 human S421 467840 APVtPPPsVGGsRQR X X -GSK3A GSK3A P49840 human GRB14 2888 Q14449 GRB14 human S366 29576856 GCSsQSIsPMRsIsE X X -GSK3A GSK3A P49840 human Tau iso8 4137 P10636-8 MAPT human S235 449080 VVRtPPKsPssAKsR X 20473 -GSK3A GSK3A P49840 human IRF3 3661 Q14653 IRF3 human S173 6370303 PCPQPLRsPsLDNPt X -GSK3A GSK3A P49840 human p21Cip1 1026 P38936 CDKN1A human T57 451222 NFDFVtEtPLEGDFA CDI X -GSK3A GSK3A P49840 human Akt1 207 P31749 AKT1 human T312 5862771 tMKtFCGtPEyLAPE Pkinase X X -GSK3A GSK3A P49840 human Doublecortin iso3 13193 Q9CXL6 Dcx mouse S327 451363 StPKSKQsPIstPts X -GSK3A GSK3A P49840 human CRMP-2 25416 P47942 Dpysl2 rat T509 448083 PVCEVSVtPKTVtPA X -GSK3A GSK3A P49840 human SRC-3 8202 Q9Y6Q9 NCOA3 human S505 454109 SPVAGVHsPMAsSGN NCOA_u2 X -CDK18 CDK18 Q07002 human Rb 5925 P06400 RB1 human S795 447979 sPykFPssPLrIPGG Rb_C X 9301 -CDK18 CDK18 Q07002 human Rb 5925 P06400 RB1 human S807 447980 PGGNIyIsPLksPyk Rb_C X 9308; 8974; 4277; 40283; 8957; 8516; 11917; 99274; 41359; 75864; 72443 -CDK18 CDK18 Q07002 human Rb 5925 P06400 RB1 human S811 448717 IyIsPLksPykIsEG Rb_C X 9308; 8974; 4277; 40283; 8957; 8516; 11917; 41359; 75864; 63276 -PDK2 PDHK2 Q15119 human PDHA1 5160 P08559 PDHA1 human S300 448259 sMsDPGVsyRtREEI E1_dh X -PDK2 PDHK2 Q15119 human PDHA1 5160 P08559 PDHA1 human S293 448258 TYRyHGHsMsDPGVs E1_dh X 31866; 37115; 48447 -PDK2 PDHK2 Q15119 human PDHA2 5161 P29803 PDHA2 human S298 458870 sMsDPGVsyRtREEI E1_dh X -PDK2 PDHK2 Q15119 human PDHA1 5160 P08559 PDHA1 human S232 448257 NRyGMGtsVERAAAs E1_dh X 15289 -PDK2 PDHK2 Q15119 human PDHA2 5161 P29803 PDHA2 human S291 458869 TYRyHGHsMsDPGVs E1_dh X 31866; 37115; 48447 -PDK2 PDHK2 Q15119 human PDHA1 18597 P35486 Pdha1 mouse S232 448257 NRyGMGtsVERAAAS E1_dh X -PRKACA PKACA iso2 P17612-2 human SEPT12 124404 Q8IYM1 SEPTIN12 human S198 63250400 PVIARADsLTMEERE Septin X -TSSK4 TSSK4 Q6SA08 human HSP90B 15516 P11499 Hsp90ab1 mouse S255 449266 PKIEDVGsDEEDDsG HSP90 X X -TSSK4 TSSK4 Q6SA08 human CREB 1385 P16220 CREB1 human S119 448228 EILsRRPsyRkILND pKID X 9187; 9196; 9198; 4095; 14228; 14001; 39561; 80120; 44864; 54960; 95995 -Oxsr1 OSR1 NP_001101664 rat NCCT 54300 P55018 Slc12a3 rat T58 469617 LRtFGYNtIDVVPAY AA_permease_N X -LIMK2 LIMK2 P53671 human Destrin 11034 P60981 DSTN human S3 449754 _____MAsGVQVADE X -LIMK2 LIMK2 P53671 human Cofilin-1 29271 P45592 Cfl1 rat S3 448444 _____MAsGVAVsDG X 3313; 3311 -LIMK2 LIMK2 P53671 human Cofilin-1 1072 P23528 CFL1 human S3 448444 _____MAsGVAVsDG X X 3313; 3311 -LIMK2 LIMK2 P53671 human G3BP-1 10146 Q13283 G3BP1 human S149 449041 VtEPQEEsEEEVEEP X -EPHB1 EphB1 P54762 human syndecan-3 P33671 Sdc3 rat Y441 458439 PDKQEEFyA______ X -EPHB1 EphB1 P54762 human CASKIN1 140722 Q8VHK2 Caskin1 rat Y296 472784 TKDYCNNyDLTSLNV SH3_2 X -EPHB1 EphB1 P54762 human GJB1 2705 P08034 GJB1 human Y243 3559630 GHRLsPEyKQNEINk X X -EPHB1 EphB1 P54762 human STAT3 20848 P42227 Stat3 mouse Y705 448192 DPGsAAPyLktkFIC X 4093; 9145; 4324; 9131; 9138; 4323; 4074; 4113; 48313; 20977; 25023; 8119; 52075; 52527; 73533; 61958; 73452; 16185; 74309 -EPHB1 EphB1 P54762 human CASKIN1 140722 Q8VHK2 Caskin1 rat Y336 4274896 TGNDRVGyFPSSLGE SH3_2 X -Mtor mTOR Q9JLN9 mouse CRMP-4 22240 Q62188 Dpysl3 mouse S522 458800 PAGstRGsPtRPNPP X -Mtor mTOR Q9JLN9 mouse DENND2B 76954 Q924W7 Dennd2b mouse S42 8145389 PVLYPPRsPIYPLsD X -Mtor mTOR Q9JLN9 mouse MRCKB 217866 Q7TT50 Cdc42bpb mouse S1692 468206 SNPsGPPsPNsPHRS X -Mtor mTOR Q9JLN9 mouse TBC1D10B 68449 Q8BHL3 Tbc1d10b mouse S643 2024345 QPPLGPsssLLsLPs X -Mtor mTOR Q9JLN9 mouse OTUD5 54644 Q3U2S4 Otud5 mouse S323 1870773108 EDEPIRVsYHRNIHY OTU X X -Mtor mTOR Q9JLN9 mouse 4E-BP1 13685 Q60876 Eif4ebp1 mouse S64 447527 FLMECRNsPVAKtPP eIF_4EBP X 9451; 9456 -Mtor mTOR Q9JLN9 mouse eIF4G 208643 Q6NZJ6 Eif4g1 mouse T212 469248 SGARtAstPtPPQtG X -Mtor mTOR Q9JLN9 mouse IGF2BP1 140486 O88477 Igf2bp1 mouse S181 453893 RGQPRQGsPVAAGAP X -Mtor mTOR Q9JLN9 mouse CHFR 231600 Q810L3 Chfr mouse S231 20651127 NGELSSLsPVFQDKE X -Mtor mTOR Q9JLN9 mouse LPIN1 14245 Q91ZP3 Lpin1 mouse S472 471355 GARsANQsPQsVGGs X -Mtor mTOR Q9JLN9 mouse C1orf131 66523 Q8CIL4 2810004N23Rik mouse S67 478543 EPLPLPGsPVRGQKK X -Mtor mTOR Q9JLN9 mouse mTOR 56717 Q9JLN9 Mtor mouse S2481 447498 tVPEsIHsFIGDGLV X 2974 -Mtor mTOR Q9JLN9 mouse 4E-BP1 13685 Q60876 Eif4ebp1 mouse T45 447496 GGtLFsttPGGtRII eIF_4EBP X X 2855; 9459; 2846; 4923; 5123; 3929; 7547; 45613; 39788 -Mtor mTOR Q9JLN9 mouse FOXK1 17425 P42128 Foxk1 mouse S427 467911 LQtPECLsREGsPIP X -Mtor mTOR Q9JLN9 mouse GRB10 14783 Q60760 Grb10 mouse S104 20651543 PPsVAPssLPPPPSQ X -Mtor mTOR Q9JLN9 mouse PKCB iso2 18751 P68404-2 Prkcb mouse T634 448592 ENFDRFFtRHPPVLt Pkinase_C X X -Mtor mTOR Q9JLN9 mouse ataxin-2L 233871 Q7TQH0 Atxn2l mouse S32 3207780 RRsPGGtsPPNGGLP X -Mtor mTOR Q9JLN9 mouse USP20 74270 Q8C6M1 Usp20 mouse S134 469014 ADEGEsEsEDDDLKP X -Mtor mTOR Q9JLN9 mouse AHNAK 66395 E9Q616 Ahnak mouse S5525 452764 ssKAsLGsLEGEVEA X -Mtor mTOR Q9JLN9 mouse Akt1 207 P31749 AKT1 human S473 447855 RPHFPQFsysAsGtA Pkinase_C X 9271; 3787; 4060; 4051; 5102; 4058; 2336; 2337; 4075; 4070; 5012; 4071; 92982; 5315; 9563; 9018; 12694; 52240; 11962; 15116; 88106; 26580; 68035; 31957; 23430; 20235 -Mtor mTOR Q9JLN9 mouse CUTL1 13047 P53564 Cux1 mouse S882 8110780 KEWPSAEsPYsQSSE X -Mtor mTOR Q9JLN9 mouse nestin 18008 Q6P5H2 Nes mouse S919 4738507 KTHEILGsLEDRNGE X -Mtor mTOR Q9JLN9 mouse PRAS40 84335 Q96B36 AKT1S1 human S183 482839 PTQQYAKsLPVSVPV PRAS X 5936 -Mtor mTOR Q9JLN9 mouse NuMA-1 101706 E9Q7G0 Numa1 mouse T1982 459921 EtHQGPGtPEsKKAT X -Mtor mTOR Q9JLN9 mouse FASN 14104 P19096 Fasn mouse T1029 27930800 LWKDNWVtFMDtMLQ PS-DH X -Mtor mTOR Q9JLN9 mouse AHNAK 66395 E9Q616 Ahnak mouse S5553 465634 sKKPRHRsNsFsDER X -Mtor mTOR Q9JLN9 mouse RC3H1 381305 Q4VGL6 Rc3h1 mouse S535 3199145 LsssAPGsPPDLLES X -Mtor mTOR Q9JLN9 mouse IRS1 16367 P35569 Irs1 mouse S635 447507 yMPMsPKsVsAPQQI X 2388 -Mtor mTOR Q9JLN9 mouse 4E-BP2 13688 P70445 Eif4ebp2 mouse T41 449368 yCttPGGtLFsttPG eIF_4EBP X -Mtor mTOR Q9JLN9 mouse LPIN1 14245 Q91ZP3 Lpin1 mouse S106 471342 IPMYLATsPILsEGA Lipin_N X -Mtor mTOR Q9JLN9 mouse ataxin-2L 233871 Q7TQH0 Atxn2l mouse T31 3207795 ARRsPGGtsPPNGGL X -Mtor mTOR Q9JLN9 mouse AFAP 70292 Q80YS6 Afap1 mouse S666 459648 EPRSGTssPQsPVFR X -Mtor mTOR Q9JLN9 mouse TBC1D10B 68449 Q8BHL3 Tbc1d10b mouse S650 4750805 ssLLsLPsLKSRGSR X -Mtor mTOR Q9JLN9 mouse ARHGAP29 214137 Q8CGF1 Arhgap29 mouse S1040 17556431 RLLLLASsPtERSSR X -Mtor mTOR Q9JLN9 mouse EHMT2 110147 Q9Z148 Ehmt2 mouse S287 14570379 RRKLNsGsLsEDLGs X -Mtor mTOR Q9JLN9 mouse PTPN13 19249 Q64512 Ptpn13 mouse S1077 10941795 KRWsIVssPEREITL X -Mtor mTOR Q9JLN9 mouse LARP 73158 Q6ZQ58 Larp1 mouse S751 453830 LPttVPEsPNyRNAR X -Mtor mTOR Q9JLN9 mouse STAT3 6774 P40763 STAT3 human S727 448191 NtIDLPMsPrTLDSL X 9134; 9136; 34911; 94994; 49081; 58978; 87544; 71958; 50804 -Mtor mTOR Q9JLN9 mouse SMCR8 237782 Q3UMB5 Smcr8 mouse S416 484908 KVLIsVGsYKssVEs X -Mtor mTOR Q9JLN9 mouse PKCH 18755 P23298 Prkch mouse S642 1239966008 IKSREDVsNFDPDFI Pkinase_C X X -Mtor mTOR Q9JLN9 mouse OTUD5 54644 Q3U2S4 Otud5 mouse S332 1870773110 HRNIHYNsVVNPNKA OTU X X -Mtor mTOR Q9JLN9 mouse DENND2B 76954 Q924W7 Dennd2b mouse S32 4770691 LSRsQsVsPPPVLYP X -Mtor mTOR Q9JLN9 mouse STAT3 20848 P42227 Stat3 mouse S727 448191 NtIDLPMsPRTLDSL X 9134; 9136; 34911; 94994; 49081; 58978; 87544; 71958; 50804 -Mtor mTOR Q9JLN9 mouse NUP188 227699 Q6ZQH8 Nup188 mouse T1515 20652092 DGLPSAVtPRAQRPs X -Mtor mTOR Q9JLN9 mouse LARP 73158 Q6ZQ58 Larp1 mouse S743 483150 EPStIARsLPttVPE X -Mtor mTOR Q9JLN9 mouse TAF140 209361 Q5HZG4 Taf3 mouse S229 453776 QKtPPVLsPVRVQDR X -Mtor mTOR Q9JLN9 mouse C1orf131 66523 Q8CIL4 2810004N23Rik mouse T53 4760272 AKKRDsEtIEDVAVE X -Mtor mTOR Q9JLN9 mouse PATL1 225929 Q3TC46 Patl1 mouse T194 17599503 VRAVPIGtPPKQMAV X -Mtor mTOR Q9JLN9 mouse POLR2A 20020 P08775 Polr2a mouse S1934 452275 sPtysPtsPKGSTYS RNA_pol_Rpb1_R X -Mtor mTOR Q9JLN9 mouse IRS1 16367 P35569 Irs1 mouse S632 447506 NGDyMPMsPKsVsAP X 2388 -Mtor mTOR Q9JLN9 mouse PRAS40 84335 Q96B36 AKT1S1 human S212 453462 EENGPPssPDLDRIA PRAS X -Mtor mTOR Q9JLN9 mouse PHLDB2 208177 Q8K1N2 Phldb2 mouse S17 20652239 QLEFQNGsLEEGFVV X -Mtor mTOR Q9JLN9 mouse 4E-BP1 1978 Q13541 EIF4EBP1 human S65 447527 FLMECrNsPVtktPP eIF_4EBP X 9451; 9456; 13443 -Mtor mTOR Q9JLN9 mouse FOXK2 68837 Q3UCQ1 Foxk2 mouse S389 483637 EsLsREGsPAPLEPE X -Mtor mTOR Q9JLN9 mouse GRB10 14783 Q60760 Grb10 mouse S103 20651540 sPPsVAPssLPPPPS X -Mtor mTOR Q9JLN9 mouse 4E-BP1 13685 Q60876 Eif4ebp1 mouse T69 447528 RNsPVAKtPPKDLPA eIF_4EBP X 9455 -Mtor mTOR Q9JLN9 mouse PTPN13 19249 Q64512 Ptpn13 mouse S1073 4169805 DTLHKRWsIVssPER X -Mtor mTOR Q9JLN9 mouse DDX18 66942 Q8K363 Ddx18 mouse T101 4762180 ANGEAAPtPPPDSEV X -Mtor mTOR Q9JLN9 mouse IRS2 384783 P81122 Irs2 mouse S616 483512 CPSFPASsPKVAYNP X -Mtor mTOR Q9JLN9 mouse DLG5 71228 E9Q9R9 Dlg5 mouse S1209 11537655 HRVLPCGsPPVPRDA X -Mtor mTOR Q9JLN9 mouse 4E-BP1 13685 Q60876 Eif4ebp1 mouse T36 447497 PPGDysttPGGtLFs eIF_4EBP X X 2855; 9459; 2846; 4923; 5123; 3929; 7547; 45613; 39788 -Mtor mTOR Q9JLN9 mouse p70S6K 6198 P23443 RPS6KB1 human S394 448806 TRQtPVDsPDDStLS Pkinase_C X 9208 -Mtor mTOR Q9JLN9 mouse IRS1 16367 P35569 Irs1 mouse S307 447558 tEsITAtsPAsMVGG X 2381 -Mtor mTOR Q9JLN9 mouse NFRKB 235134 Q6PIJ4 Nfrkb mouse S351 453698 PTLsQAPsPLAISSI X -Mtor mTOR Q9JLN9 mouse USP20 74270 Q8C6M1 Usp20 mouse S132 469013 AVADEGEsEsEDDDL X -Mtor mTOR Q9JLN9 mouse WIPI2 74781 Q80W47 Wipi2 mouse S395 3217428 KGAYVPssPtRLGKG X 13571 -Mtor mTOR Q9JLN9 mouse PHLDB1 102693 Q6PDH0 Phldb1 mouse S1007 20652230 SVATLGRsPsPKSAL X -Mtor mTOR Q9JLN9 mouse FASN 14104 P19096 Fasn mouse T1033 27930801 NWVtFMDtMLQVSIL PS-DH X -Mtor mTOR Q9JLN9 mouse FOXK1 17425 P42128 Foxk1 mouse S431 467912 ECLsREGsPIPHDPD X -Mtor mTOR Q9JLN9 mouse NFAT3 73181 Q8K120 Nfatc4 mouse S170 448860 GGAFFsPsPGSSSLS X -Mtor mTOR Q9JLN9 mouse SZT2 230676 A2A9C3 Szt2 mouse S3230 14575118 TPGSLVGsPREASGM X -Mtor mTOR Q9JLN9 mouse MCL1 17210 P97287 Mcl1 mouse T144 455375 ADGsLPStPPPPEEE X 4579 -Mtor mTOR Q9JLN9 mouse AFAP 70292 Q80YS6 Afap1 mouse S665 3206235 IEPRSGTssPQsPVF X -Mtor mTOR Q9JLN9 mouse NuMA-1 101706 E9Q7G0 Numa1 mouse S1974 487252 QQRKRVssEtHQGPG X -Mtor mTOR Q9JLN9 mouse 4E-BP1 1978 Q13541 EIF4EBP1 human T37 447497 PPGDysttPGGtLFs eIF_4EBP X 2855; 9459; 2846; 5123; 3929; 7547; 45613; 39788 -Mtor mTOR Q9JLN9 mouse MAP1B 17755 P14873 Map1b mouse S1260 454136 sLsPsPPsPIEKtPL X -Mtor mTOR Q9JLN9 mouse TIF1B 10155 Q13263 TRIM28 human S824 460839 LPGAGLssQELsGGP X 4127 -Mtor mTOR Q9JLN9 mouse MAP1B 17755 P14873 Map1b mouse S1247 456401 DVsDERLsPAKsPsL X -Mtor mTOR Q9JLN9 mouse PRAS40 84335 Q96B36 AKT1S1 human S221 2506802 DLDRIAAsMRALVLR PRAS X -Mtor mTOR Q9JLN9 mouse PHLDB1 102693 Q6PDH0 Phldb1 mouse S1009 4739736 ATLGRsPsPKSALLA X -Mtor mTOR Q9JLN9 mouse TIF1B 10155 Q13263 TRIM28 human S473 452391 sGVkRsRsGEGEVsG X -Mtor mTOR Q9JLN9 mouse 4E-BP2 13688 P70445 Eif4ebp2 mouse T37 449367 LPQDyCttPGGtLFs eIF_4EBP X -Mtor mTOR Q9JLN9 mouse Akt1 11651 P31750 Akt1 mouse S473 447855 RPHFPQFsysAsGtA Pkinase_C X 9271; 3787; 4060; 4051; 5102; 4058; 2336; 2337; 4075; 4070; 5012; 4071; 92982; 5315; 9563; 9018; 12694; 52240; 11962; 15116; 88106; 26580; 68035; 31957; 23430; 20235 -Mtor mTOR Q9JLN9 mouse Jun 16476 P05627 Jun mouse T242 450450 VPEMPGEtPPLsPID Jun X -Mtor mTOR Q9JLN9 mouse AHNAK 66395 E9Q616 Ahnak mouse S5536 483522 EVEAEAssPKGKFsL X -Mtor mTOR Q9JLN9 mouse Jun 16476 P05627 Jun mouse S246 450451 PGEtPPLsPIDMESQ X 2994 -Mtor mTOR Q9JLN9 mouse DENND2B 76954 Q924W7 Dennd2b mouse S30 4770685 ETLSRsQsVsPPPVL X -Mtor mTOR Q9JLN9 mouse AFAP 70292 Q80YS6 Afap1 mouse S669 453460 SGTssPQsPVFRHRt X -Mtor mTOR Q9JLN9 mouse 4E-BP1 1978 Q13541 EIF4EBP1 human T46 447496 GGtLFsttPGGtRII eIF_4EBP X 2855; 9459; 2846; 4923; 5123; 3929; 7547; 45613; 39788 -Mtor mTOR Q9JLN9 mouse AKAP11 219181 E9Q777 Akap11 mouse S987 20650804 FLDFSDNsPHRSLLV X -Mtor mTOR Q9JLN9 mouse OTUD5 54644 Q3U2S4 Otud5 mouse S503 483402 AGGDRAtsPLVSLYP X X -Mtor mTOR Q9JLN9 mouse NFAT3 73181 Q8K120 Nfatc4 mouse S168 448859 QGGGAFFsPsPGSSS X -Mtor mTOR Q9JLN9 mouse TOPORS 106021 Q80Z37 Topors mouse S1016 4748993 EPSRPVPsPRTSLSS X -Mtor mTOR Q9JLN9 mouse AHNAK 66395 E9Q616 Ahnak mouse T5571 466948 APstPtGtLEFAGGD X -Mtor mTOR Q9JLN9 mouse FLNA 192176 Q8BTM8 Flna mouse S1338 3181751 VDVTYDGsPVPSSPF Filamin X -Mtor mTOR Q9JLN9 mouse MST1 58231 Q9JI11 Stk4 mouse S438 4271929 GDyEFLKsWTVEDLQ Mst1_SARAH X -Mtor mTOR Q9JLN9 mouse TBC1D10B 68449 Q8BHL3 Tbc1d10b mouse S647 3212796 GPsssLLsLPsLKSR X -Mtor mTOR Q9JLN9 mouse AKAP11 219181 E9Q777 Akap11 mouse T1092 469517 DRNVIPDtPPstPLV X -Mtor mTOR Q9JLN9 mouse NuMA-1 101706 E9Q7G0 Numa1 mouse S1973 487347 RQQRKRVssEtHQGP X -MET Met P08581 human Ron 4486 Q04912 MST1R human Y1353 456487 SALLGDHyVQLPATy X -MET Met P08581 human FIS1 51024 Q9Y3D6 FIS1 human Y38 1875830300 sKSTQFEyAWCLVRS Fis1_TPR_N X X -MET Met P08581 human IRS1 3667 P35568 IRS1 human Y612 447555 tLHtDDGyMPMsPGV X X -MET Met P08581 human FAK 5747 Q05397 PTK2 human Y925 447966 DRsNDkVyENVtGLV Focal_AT X X 3284 -MET Met P08581 human Met 4233 P08581 MET human Y1349 448472 stFIGEHyVHVNAty X 3133; 3121 -MET Met P08581 human Met 4233 P08581 MET human Y1365 448474 NVKCVAPyPsLLssE X -MET Met P08581 human IRS1 3667 P35568 IRS1 human Y896 447556 EPKsPGEyVNIEFGS X X 3070 -MET Met P08581 human FAK 5747 Q05397 PTK2 human Y577 447890 yMEDstyyKAsKGKL PK_Tyr_Ser-Thr X X 3281 -MET Met P08581 human RHOA 387 P61586 RHOA human Y42 150180312 VPTVFENyVADIEVD Ras X X -MET Met P08581 human Ron 4486 Q04912 MST1R human Y1360 456488 yVQLPATyMNLGPST X -MET Met P08581 human Ron 4486 Q04912 MST1R human Y1238 454933 RDILDREyysVQQHR PK_Tyr_Ser-Thr X -MET Met P08581 human IQGAP1 8826 P46940 IQGAP1 human Y1510 450791 LVkLQQtyAALNskA RasGAP_C X X -MET Met P08581 human FAK 5747 Q05397 PTK2 human Y407 447888 IIDEEDtytMPSTRD X X -MET Met P08581 human Met 4233 P08581 MET human Y1230 448866 FGLARDMyDkEyysV PK_Tyr_Ser-Thr X -MET Met P08581 human PARP1 142 P09874 PARP1 human Y907 53332701 MVSKSANyCHTSQGD PARP X X -MET Met P08581 human SHC1 6464 P29353 SHC1 human Y427 448511 ELFDDPsyVNVQNLD X 2431 -MET Met P08581 human Met 4233 P08581 MET human Y1356 448473 yVHVNAtyVNVKCVA X -MET Met P08581 human FAK 5747 Q05397 PTK2 human Y5 7445815 ___MAAAyLDPNLNH X X -MET Met P08581 human FAK 5747 Q05397 PTK2 human Y397 447887 sVsEtDDyAEIIDEE X X 3283; 8556 -MET Met P08581 human FAK 5747 Q05397 PTK2 human Y861 447965 PIGNQHIyQPVGKPD X X -MET Met P08581 human PBK 55872 Q96KB5 PBK human Y74 473837 NPICNDHyRsVyQkR Pkinase X X -MET Met P08581 human FAK 5747 Q05397 PTK2 human Y194 18122800 ALEKKSNyEVLEkDV FERM_M X X -MET Met P08581 human Met 4233 P08581 MET human Y1234 448470 RDMyDkEyysVHNkt PK_Tyr_Ser-Thr X X 4091; 3129; 3126; 3077; 12468; 4033; 98954 -MET Met P08581 human FAK 5747 Q05397 PTK2 human Y576 447889 RyMEDstyyKAsKGK PK_Tyr_Ser-Thr X X 3281 -MET Met P08581 human INSR 3643 P06213 INSR human Y1185 447680 FGMTRDIyEtDyyRk PK_Tyr_Ser-Thr X X 3021; 80732 -MET Met P08581 human Met 4233 P08581 MET human Y1235 448471 DMyDkEyysVHNktG PK_Tyr_Ser-Thr X X 4091; 3129; 3126; 3077; 12468; 4033; 98954 -MET Met P08581 human GSK3B 2932 P49841 GSK3B human Y56 1867735501 DRPQEVSyTDTKVIG Pkinase X X -MET Met P08581 human Ron 4486 Q04912 MST1R human Y1239 457984 DILDREyysVQQHRH PK_Tyr_Ser-Thr X -Frk FRK Q922K9 mouse FRK 14302 Q922K9 Frk mouse Y394 452029 kVDNEDIyESKHEIK PK_Tyr_Ser-Thr X -Frk FRK Q922K9 mouse NMDAR2B 14812 Q01097 Grin2b mouse Y1070 461055 IsTHtVTyGNIEGNA NMDAR2_C X 4209 -PRKACA PKACA P00517 cow CETN1 1068 Q12798 CETN1 human S170 1430241100 LRIMKKTsLY_____ X -PRKACA PKACA P00517 cow DJ-1 117287 O88767 Park7 rat S155 2566140 kDGLILtsRGPGTSF DJ-1_PfpI X -PRKACA PKACA P00517 cow CKB 24264 P07335 Ckb rat S178 2565343 GRYYALKsMTEAEQQ ATP-gua_Ptrans X -PRKACA PKACA P00517 cow ADD1 118 P35611 ADD1 human S481 451596 KEDGHRtstsAVPNL X -PRKACA PKACA P00517 cow PTHR 56813 P25961 Pth1r rat S491 452061 KRKARsGsssYsYGP X -PRKACA PKACA P00517 cow phosducin 287007 P19632 PDC cow S73 451205 ERFSRKMsVQEYELI Phosducin X -PRKACA PKACA P00517 cow PTRF 287710 P85125 Cavin1 rat T304 2566127 DKLRKsFtPDHVVyA PTRF_SDPR X -PRKACA PKACA P00517 cow smMLCK 288057 D3ZFU9 Mylk rat S1431 2565323 LATCRSTsFNVQDLL fn3 X -PRKACA PKACA P00517 cow TNNI3 P02646 TNNI3 rabbit S151 451822 LRLRVRIsADAMMQA Troponin X -PRKACA PKACA P00517 cow PDIA6 286906 Q63081 Pdia6 rat S375 2565411 kFALLKGsFSEQGIN X -PRKACA PKACA P00517 cow MRLC2 50685 P18666 Myl12b rat T19 448596 KKRPQRAtsNVFAMF X -PRKACA PKACA P00517 cow DARPP-32 360616 Q6J4I0 Ppp1r1b rat S137 448046 EEDEEEDsQAEVLKG DARPP-32 X -PRKACA PKACA P00517 cow TRPV1 83810 O35433 Trpv1 rat S820 456218 QLKHYTGsLkPEDAE X -PRKACA PKACA P00517 cow ACTG1 287876 P63259 Actg1 rat S33 2565379 APRAVFPsIVGRPRH Actin X -PRKACA PKACA P00517 cow GSBS 10842 O96001 PPP1R17 human T68 2999005 KKPRRKDtPALHIPP X -PRKACA PKACA P00517 cow GCAP2 286851 P51177 GUCA1B cow S201 455322 ISQQRRKsAMF____ X -PRKACA PKACA P00517 cow BRAF 107315883 P34908 BRAF quail S469 447803 PQRERKSsSSSEDRN X -PRKACA PKACA P00517 cow TNNI3 P02646 TNNI3 rabbit S22 448423 PAPVRRRsSANYRAY Troponin-I_N X -PRKACA PKACA P00517 cow profilin 1 18643 P62962 Pfn1 mouse T90 23135104 EFTMDLRtKstGGAP Profilin X -PRKACA PKACA P00517 cow eEF1B 363241 B5DEN5 Eef1b2 rat S106 452653 DDIDLFGsDDEEEsE EF-1_beta_acid X -PRKACA PKACA P00517 cow SIK 17691 Q60670 Sik1 mouse S577 465992 FQEGRRAsDTSLTQG X -PRKACA PKACA P00517 cow TNNI3 511094 P08057 TNNI3 cow S25 448424 PPVRRRssANYRAYA Troponin-I_N X -PRKACA PKACA P00517 cow RYR1 100009540 P11716 RYR1 rabbit S2843 451818 KKKTRKIsQTAQTYD X -PRKACA PKACA P00517 cow GLUT4 25139 P19357 Slc2a4 rat S488 451207 ATFRRtPsLLEQEVK X -PRKACA PKACA P00517 cow Tau iso5 4137 P10636-5 MAPT human S325 449104 RVQSKIGsLDNITHV Tubulin-binding X -PRKACA PKACA P00517 cow desmin 395906 P02542 DES chicken S29 466347 sPVFPRAsFGSRGsG Filament_head X -PRKACA PKACA P00517 cow FLNA 293860 C0JPT7 Flna rat S1518 2565475 YVPSREGsYSISVLY Filamin X -PRKACA PKACA P00517 cow TH 280707 P17289 TH cow S40 448545 RFVGRRQsLIQDARK TOH_N X -PRKACA PKACA P00517 cow HRas 15461 Q61411 Hras mouse S177 455374 kLNPPDEsGPGCMSC X -PRKACA PKACA P00517 cow PKAR2A 518399 P00515 PRKAR2A cow S96 458326 GRFDRRVsVCAETYN X -PRKACA PKACA P00517 cow ADD1 118 P35611 ADD1 human S59 451695 MEQkKRVsMILQsPA X -PRKACA PKACA P00517 cow NOLC1 64896 P41777 Nolc1 rat S113 455684 AAPAKRAsLPQHAGk X -PRKACA PKACA P00517 cow TH iso4 7054 P07101-4 TH human S44 448545 RFIGRRQsLIEDARK TOH_N X 2791 -PRKACA PKACA P00517 cow profilin 1 18643 P62962 Pfn1 mouse S57 14578217 VLVGkDRssFFVNGL Profilin X -PRKACA PKACA P00517 cow FETUB 83928 Q9QX79 Fetub rat S303 2565455 SITAPRGsIQHLPEQ X -PRKACA PKACA P00517 cow SNAP-25 25012 P60881 Snap25 rat T138 449875 GGFIRRVtNDARENE SNAP-25 X -PRKACA PKACA P00517 cow S6 29304 P62755 Rps6 rat S235 448092 IAKRRRLssLRAsts X 5006; 4856; 4857; 4858; 4851; 4803; 2211; 3945; 3985; 5316; 4854; 8520; 48319; 40643; 9865; 38573; 14733; 27036; 34411; 62016; 62788; 81736; 97935; 99457; 15448 -PRKACA PKACA P00517 cow MRLC1 296313 Q64122 Myl9 rat S20 1863500 KRPQSAtsNVFAMFD X 3674; 3671; 3675; 95777 -PRKACA PKACA P00517 cow Vimentin 81818 P31000 Vim rat S412 451764 EGEESRIsLPLPNFs X -PRKACA PKACA P00517 cow Tau iso8 4137 P10636-8 MAPT human S320 450139 VDLskVtskCGsLGN Tubulin-binding X -PRKACA PKACA P00517 cow smAKAP 84281 Q9BSF0 C2orf88 human S66 54468602 LEYAHRLsQDILCDA SmAKAP X -PRKACA PKACA P00517 cow SMTNL1 68678 Q99LM3 Smtnl1 mouse S301 2755200 RAPERRVsAPSRPRG X -PRKACA PKACA P00517 cow SCN2A 24766 P04775 Scn2a rat S610 451195 DNDSRRDsLFVPHRH Na_trans_cytopl X -PRKACA PKACA P00517 cow Tau iso5 4137 P10636-5 MAPT human S195 450221 PPKSGDRsGYssPGs X -PRKACA PKACA P00517 cow eEF1B 363241 B5DEN5 Eef1b2 rat S140 2566132 KPAVVAKssILLDVK X -PRKACA PKACA P00517 cow PDIA6 286906 Q63081 Pdia6 rat S88 2565407 VNADKHQsLGGQYGV Thioredoxin X -PRKACA PKACA P00517 cow NDUFS3 295923 D3ZG43 Ndufs3 rat S59 2565331 DVTHkRLsAFGEYVA X -PRKACA PKACA P00517 cow TRPV1 83810 O35433 Trpv1 rat S116 454886 PRLYDRRsIFDAVAQ X X -PRKACA PKACA P00517 cow HSP27 24471 P42930 Hspb1 rat S86 448403 RALNRQLssGVsEIR X 2406; 2401; 9709; 11892; 64293 -PRKACA PKACA P00517 cow GSBS 10842 O96001 PPP1R17 human T119 2999004 kKPRRKDtPALHMSP X -PRKACA PKACA P00517 cow Zyxin 114636 Q99MM3 Zyx rat S144 460645 QPREKVssIDLEIDS X 4863; 8467 -PRKACA PKACA P00517 cow desmin 395906 P02542 DES chicken S35 466350 AsFGSRGsGSsVTSR Filament_head X -PRKACA PKACA P00517 cow Tau iso5 4137 P10636-5 MAPT human S262 447930 NVKSKIGsTENLKHQ Tubulin-binding X -PRKACA PKACA P00517 cow NMDAR1 24408 P35439 Grin1 rat S897 448256 sFKRRRssKDtSTGG X -PRKACA PKACA P00517 cow H2B 615043 P62808 H2BC19 cow S32 447801 DGKKRKRsRKEsYSV Histone X -PRKACA PKACA P00517 cow SDPR 316384 Q66H98 Cavin2 rat S332 4732711 GsFTEGLsEAsLPSG X -PRKACA PKACA P00517 cow PTRF 287710 P85125 Cavin1 rat S368 452129 TDLLRGssPDVHTLL X -PRKACA PKACA P00517 cow Tau iso5 4137 P10636-5 MAPT human T231 449079 KKVAVVRtPPKsPSS X 20473; 71429 -PRKACA PKACA P00517 cow TNNI3 P02646 TNNI3 rabbit T143 451483 RGKFKRPtLRLRVRI Troponin X -PRKACA PKACA P00517 cow PGM5 679990 D3ZVR9 Pgm5 rat T31 2565495 GGGLRRPtGLFEGQR PGM_PMM_I X -PRKACA PKACA P00517 cow Serpina3g 24794 P05545 Serpina3k rat S313 2565339 ELRMPKFsISTDYNL Serpin X -PRKACA PKACA P00517 cow CRYBB2 287011 P02522 CRYBB2 cow S204 451609 QRGAFHPsS______ X -PRKACA PKACA P00517 cow GANAB 293721 D3ZAN3 Ganab rat S769 2565327 GSPESRLsFQHDPET X -PRKACA PKACA P00517 cow profilin 1 18643 P62962 Pfn1 mouse T93 15405470 MDLRtKstGGAPTFN Profilin X -PRKACA PKACA P00517 cow AHNAK 191572 A0A0G2JUA5 Ahnak rat S5038 452760 EGPKVRGsLGATGEL X -PRKACA PKACA P00517 cow GFAP 396562 F1RR02 GFAP pig S8 449618 MERRRVtsAARRsYV Filament_head X -PRKACA PKACA P00517 cow TPH2 121278 Q8IWU9 TPH2 human S19 470085 YWARRGFsLDSAVPE X -PRKACA PKACA P00517 cow MYPT1 116670 Q10728 Ppp1r12a rat S854 451999 RPREKRRstGVSFWT X -PRKACA PKACA P00517 cow GBF1 309451 F1M8X9 Gbf1 rat S174 2565467 ICFEMRLsELLRKSA DCB X -PRKACA PKACA P00517 cow BAD 12015 Q61337 Bad mouse S112 447860 ETRsRHssyPAGtEE Bcl-2_BAD X 9291; 5284; 9296; 5193; 11865; 94223 -PRKACA PKACA P00517 cow 14-3-3 eta 22629 P68510 Ywhah mouse S59 450482 VVGARRSsWRVIssI 14-3-3 X 52631 -PRKACA PKACA P00517 cow HSP27 24471 P42930 Hspb1 rat S15 448401 FsLLRsPsWEPFRDW X -PRKACA PKACA P00517 cow DMN 308709 Q810D0 Synm rat S777 2565443 EVDDVsPsPKGFIEE X -PRKACA PKACA P00517 cow Tau iso5 4137 P10636-5 MAPT human S198 449551 SGDRsGYssPGsPGt X -PRKACA PKACA P00517 cow HSP90A 299331 P82995 Hsp90aa1 rat S211 2565447 kEIVkKHsQFIGYPI HSP90 X -PRKACA PKACA P00517 cow PTHR 56813 P25961 Pth1r rat S473 452059 VQAEIRKsWsRWTLA X -PRKACA PKACA P00517 cow SCN2A 24766 P04775 Scn2a rat S573 451193 LFsPrRNsRAsLFNF Na_trans_cytopl X -PRKACA PKACA P00517 cow ADD2 119 P35612 ADD2 human T55 451694 MEQKKRVtMILQsPs X -PRKACA PKACA P00517 cow ATP5J 94271 P21571 Atp5pf rat S57 2565359 YkAKRLAsGGPVDTG ATP-synt_F6 X -PRKACA PKACA P00517 cow BRAF 107315883 P34908 BRAF quail S486 447804 KTLGRRDsSDDWEIP X -PRKACA PKACA P00517 cow TRPV1 83810 O35433 Trpv1 rat T144 456216 QRSKKRLtDSEFKDP Ank_2 X -PRKACA PKACA P00517 cow LPP 288010 Q5XI07 Lpp rat S117 460573 TLEERRssLDAEIDS X -PRKACA PKACA P00517 cow MRLC1 296313 Q64122 Myl9 rat T19 1863501 KKRPQSAtsNVFAMF X 3674; 95777 -PRKACA PKACA P00517 cow FLNA 293860 C0JPT7 Flna rat T2328 471891 SGDARRLtVSSLQES Filamin X -PRKACA PKACA P00517 cow PEDF 287526 Q80ZA3 Serpinf1 rat T227 455233 KFDSRKttLQDFHLD Serpin X -PRKACA PKACA P00517 cow coronin 1C 501841 NP_001102797 Coro1c rat S354 2565335 IMTVPRKsDLFQDDL WD40_4 X -PRKACA PKACA P00517 cow ANXA1 25380 P07150 Anxa1 rat T216 447973 AGERRKGtDVNVFNT Annexin X -PRKACA PKACA P00517 cow Merlin 4771 P35240 NF2 human S518 448282 DTDMKRLsMEIEKEK ERM_C X 9163; 13281 -PRKACA PKACA P00517 cow FLNA 293860 C0JPT7 Flna rat S2144 451357 TRRRRAPsVANVGsH Filamin X 4761 -PRKACA PKACA P00517 cow MCAM 78967 Q9EPF2 Mcam rat S95 2566136 GEYEHRLsLHGPGAT V-set X -PRKACA PKACA P00517 cow STMN1 3925 P16949 STMN1 human S16 448554 kELEKrAsGQAFELI Stathmin X 3353 -PRKACA PKACA P00517 cow GABRB1 14400 P50571 Gabrb1 mouse S434 450244 GRIRRRAsQLKVKIP Neur_chan_memb X -PRKACA PKACA P00517 cow hnRNP A1 3178 P09651 HNRNPA1 human S199 451555 sQrGrsGsGNFGGGr X -PRKACA PKACA P00517 cow FLNA 293860 C0JPT7 Flna rat S2515 448843 VTGPRLVsNHSLHET X -PRKACA PKACA P00517 cow CGB 1082 P0DN86 CGB3 human T117 451336 CALCRRStTDCGGPK Cys_knot X -PRKACA PKACA P00517 cow DJ-1 117287 O88767 Park7 rat T154 2566111 EkDGLILtsRGPGTS DJ-1_PfpI X -PRKACA PKACA P00517 cow TNNI3 21954 P48787 Tnni3 mouse S24 448424 APVRRRssANyRAYA Troponin-I_N X -PRKACA PKACA P00517 cow CP 24268 P13635 Cp rat T668 2565351 SKGERRDtANLFPHK X -PRKACA PKACA P00517 cow GJB1 29584 P08033 Gjb1 rat S233 451163 NPPSRKGsGFGHRLs X X -PRKACA PKACA P00517 cow PDE5A 8654 O76074 PDE5A human S102 448178 GTPTRKIsAsEFDRP X -PRKACA PKACA P00517 cow Calnexin 29144 P35565 Canx rat S582 449100 EDEILNRsPRNRKPR X -PRKACA PKACA P00517 cow RPN1 25596 P07153 Rpn1 rat S65 2566144 GGSTARAssFVLALE Ribophorin_I X -PRKACA PKACA P00517 cow VASP 7408 P50552 VASP human S239 448380 GAKLRKVsKQEEASG X 3114; 37565 -PRKACA PKACA P00517 cow ACTA1 29437 P68136 Acta1 rat S35 2565387 APRAVFPsIVGRPRH Actin X -PRKACA PKACA P00517 cow MARCKS 4082 P29966 MARCKS human S159 447786 kkKKKRFsFkKsFkL MARCKS X 2741; 11992 -PRKACA PKACA P00517 cow BAD 12015 Q61337 Bad mouse S155 447863 GRELRRMsDEFEGsF Bcl-2_BAD X 9297 -PRKACA PKACA P00517 cow desmin 64362 P48675 Des rat S81 460578 LGTTRAPsYGAGELL Filament_head X -PRKACA PKACA P00517 cow HSP90A 299331 P82995 Hsp90aa1 rat S263 448662 PEIEDVGsDEEEEEK HSP90 X -PRKACA PKACA P00517 cow DARPP-32 282459 P07516 PPP1R1B cow T34 448047 MIRRRRPtPAMLFRL DARPP-32 X 12438 -PRKACA PKACA P00517 cow RPN1 25596 P07153 Rpn1 rat S66 2566115 GSTARAssFVLALEP Ribophorin_I X -PRKACA PKACA P00517 cow AHNAK 191572 A0A0G2JUA5 Ahnak rat T159 2565491 ITVTRRVtAYTVDVT X -PRKACA PKACA P00517 cow PDE6G 281977 P04972 PDE6G cow T35 450149 PKFKQRQtRQFKSKP PDE6_gamma X -PRKACA PKACA P00517 cow desmin 395906 P02542 DES chicken S50 449614 VYQVSRTsAVPTLsT Filament_head X -PRKACA PKACA P00517 cow TNNI3 511094 P08057 TNNI3 cow S24 448423 PPPVRRRssANYRAY Troponin-I_N X -PRKACA PKACA P00517 cow TNNI3 P02646 TNNI3 rabbit S77 451839 GEKGRALsTRCQPLE Troponin X -PRKACA PKACA P00517 cow CACNB2 116600 Q8VGC3 Cacnb2 rat S529 1868239900 KKSQHRSssATHQNH X -PRKACA PKACA P00517 cow TRPV1 83810 O35433 Trpv1 rat S502 450016 YFLQRRPsLKSLFVD Ion_trans X -PRKACA PKACA P00517 cow GPIbB 2812 P13224 GP1BB human S191 456005 ARAAARLsLtDPLVA X -PRKACA PKACA P00517 cow TRPV1 83810 O35433 Trpv1 rat S774 456217 EGVKRTLsFSLRSGR X -PRKACA PKACA P00517 cow FLNC 362332 D3ZHA0 Flnc rat T2413 2565483 SDDARRLtVTSLQET Filamin X -PRKACA PKACA P00517 cow PFKM 100345647 P00511 PFKM rabbit S775 458322 EHISRKRsGEATV__ X -PRKACA PKACA P00517 cow PFKFB2 287019 P26285 PFKFB2 cow S484 452046 IRRPRNYsVGSRPLQ X -PRKACA PKACA P00517 cow CAMKK2 83506 O88831 Camkk2 rat T144 15425433 PRMPRRPtVESHHVS X -PRKACA PKACA P00517 cow FKBP9 297123 Q66H94 Fkbp9 rat S277 2565419 SCERRSQsGDFLRYH FKBP_C X -PRKACA PKACA P00517 cow ACTA1 29437 P68136 Acta1 rat S201 2565391 ILTERGysFVTtAER Actin X -PRKACA PKACA P00517 cow Destrin 502674 Q7M0E3 Dstn rat S147 2565439 PEDLNRTsIAEKLGG Cofilin_ADF X -PRKACA PKACA P00517 cow HSP27 24471 P42930 Hspb1 rat S102 2565371 TADRWRVsLDVNHFA HSP20 X -PRKACA PKACA P00517 cow MYBPC3 17868 O70468 Mybpc3 mouse S282 471080 AGAGRRtsDsHEDAG X -PRKACA PKACA P00517 cow Tau iso5 4137 P10636-5 MAPT human T205 447933 ssPGsPGtPGSRSRT X 25377; 43964; 53001; 49561; 20060; 33032; 30505; 20739; 98160 -PRKACA PKACA P00517 cow FLNA 293860 C0JPT7 Flna rat S343 2565471 NDKNRTFsVWYVPEV Filamin X -PRKACA PKACA P00517 cow CETN2 1069 P41208 CETN2 human S170 448199 LRIMkKTsLY_____ X X -PRKACA PKACA P00517 cow eEF1B 363241 B5DEN5 Eef1b2 rat S141 476101 PAVVAKssILLDVKP EF1_GNE X -PRKACA PKACA P00517 cow PTRF 287710 P85125 Cavin1 rat S302 465873 SRDKLRKsFtPDHVV PTRF_SDPR X -PRKACA PKACA P00517 cow A-albumin 282708 P36953 Afm rat T363 2565367 YDYSRRHtELSTPEL Serum_albumin X -PRKACA PKACA P00517 cow MYPT1 116670 Q10728 Ppp1r12a rat S696 451998 QARQSRRstQGVTLT X -PRKACA PKACA P00517 cow GFAP 396562 F1RR02 GFAP pig S34 449621 LGPGPRLsLARMPPP Filament_head X -PRKACA PKACA P00517 cow TRPV1 83810 O35433 Trpv1 rat T370 455383 RHLSRKFtEWAYGPV X X -PRKACA PKACA P00517 cow RIL 24915 P36202 Pdlim4 rat S119 468635 PATsRRssIsGIsLE X -PRKACA PKACA P00517 cow RAF1 5894 P04049 RAF1 human S43 447744 FGyQRRAsDDGKLtD X -PRKACA PKACA P00517 cow ACTN1 81634 Q9Z1P2 Actn1 rat S404 2565463 EkFRQKAsIHEAWTD Spectrin X -PRKACA PKACA P00517 cow S6 29304 P62755 Rps6 rat S240 448094 RLssLRAstsKsESs X 2215; 5364; 5018; 93315; 5044; 13020; 14236; 9468; 35708; 88441; 34918 -PRKACA PKACA P00517 cow PDE10A iso2 10846 Q9Y233-2 PDE10A human T16 478273 AScFRRLtECFLSPS X -PRKACA PKACA P00517 cow ATF-2 1386 P15336 ATF2 human S62 451440 FGPARNDsVIVADQt X -PRKACA PKACA P00517 cow H1C 513971 P02253 H1-2 cow S36 450120 AGARRKAsGPPVSEL X -PRKACA PKACA P00517 cow NOLC1 64896 P41777 Nolc1 rat S628 455686 KGEKRAssPFRRVRE X -PRKACA PKACA P00517 cow Zyxin 114636 Q99MM3 Zyx rat S143 460644 PQPREKVssIDLEID X 4863; 8467 -PRKACA PKACA P00517 cow phosducin 25343 P20942 Pdc rat S73 451205 ERMSRKMsIQEYELI Phosducin X -PRKACA PKACA P00517 cow MYPT1 116670 Q10728 Ppp1r12a rat T855 452075 PREKRRstGVSFWTQ X 4563 -PRKACA PKACA P00517 cow RCN3 494125 I6L9G5 Rcn3 rat S117 2565399 QQRHIRDsVSAAWHT X -PRKACA PKACA P00517 cow MCAM 78967 Q9EPF2 Mcam rat S85 2566107 VHQGKGQsEPGEYEH V-set X -PRKACA PKACA P00517 cow Oct7 18992 P31360 Pou3f2 mouse S362 486486 RKRKKRtsIEVSVKG Homeodomain X -PRKACA PKACA P00517 cow AQP0 280859 P06624 MIP cow S243 451790 ILKGSRPsEsNGQPE X -PRKACA PKACA P00517 cow PFKFB1 24638 P07953 Pfkfb1 rat S33 456206 VLQRRRGsSIPQFTN 6PF2K X -PRKACA PKACA P00517 cow CFTR 1080 P13569 CFTR human S660 449979 FSAERRNsILTETLH CFTR_R X X -PRKACA PKACA P00517 cow CACNB2 116600 Q8VGC3 Cacnb2 rat S530 451474 KSQHRSssATHQNHR X -PRKACA PKACA P00517 cow TPH2 121278 Q8IWU9 TPH2 human S104 1033700 RKSRRRSsEVEIFVD X -PRKACA PKACA P00517 cow ATP1A1 24211 P06685 Atp1a1 rat S943 451649 ICKTRRNsVFQQGMK Cation_ATPase_C X -PRKACA PKACA P00517 cow Oct7 5454 P20265 POU3F2 human S360 486486 RKRKKRTsIEVSVKG Homeodomain X -PRKACA PKACA P00517 cow Tau iso5 4137 P10636-5 MAPT human S373 449082 PVVsGDTsPRHLSNV X 35834; 20194; 98523; 91600; 49562 -PRKACA PKACA P00517 cow AHNAK 191572 A0A0G2JUA5 Ahnak rat S136 2565487 KIKPRLRsEDGVEGD X -PRKACA PKACA P00517 cow MCAM 78967 Q9EPF2 Mcam rat S426 2565319 LNRTRRVsVGIFGSP X -PRKACA PKACA P00517 cow PSEN1 5663 P49768 PSEN1 human S310 452183 PEAQRRVsKNskyNA Presenilin X -PRKACA PKACA P00517 cow FLNA 2316 P21333 FLNA human S2152 451357 tRRRRAPsVANVGsH Filamin X 4761 -PRKACA PKACA P00517 cow TNNI3 21954 P48787 Tnni3 mouse S23 448423 PAPVRRRssANyRAY Troponin-I_N X -PRKACA PKACA P00517 cow ADD2 119 P35612 ADD2 human S713 449802 KKKFRtPsFLKKsKK X -PRKACA PKACA P00517 cow TH iso2 7054 P07101-2 TH human S67 448545 RFIGRRQsLIEDARK TOH_N X 2791 -PRKACA PKACA P00517 cow ADD1 118 P35611 ADD1 human S726 449829 KKKFRtPsFLKKsKK X -PRKACA PKACA P00517 cow MYBPC3 17868 O70468 Mybpc3 mouse S302 471081 sLLKKRDsFRRDskL X -PRKACA PKACA P00517 cow S6 29304 P62755 Rps6 rat S236 448093 AKRRRLssLRAstsK X 5006; 4856; 4857; 4858; 4851; 4803; 2211; 3945; 3985; 5316; 4854; 8520; 48319; 40643; 9865; 38573; 14733; 27036; 34411; 62016; 62788; 81736; 97935; 99457; 15448 -PRKACA PKACA P00517 cow ACTG2 25365 P63269 Actg2 rat S200 2565800 ILTERGysFVTtAER Actin X -PRKACA PKACA P00517 cow SCN2A 24766 P04775 Scn2a rat S687 451194 EIRKRRsssyHVsMD Na_trans_cytopl X -PRKACA PKACA P00517 cow ITIH4 54404 Q5EBC0 Itih4 rat S225 2565395 TLSQQRKsQNEQDTV X -PRKACA PKACA P00517 cow FLNA 293860 C0JPT7 Flna rat S2607 2565479 HMGSRLYsVSYLLKD Filamin X -PRKACA PKACA P00517 cow PEDF 287526 Q80ZA3 Serpinf1 rat T226 2566122 TKFDSRKttLQDFHL Serpin X -PRKACA PKACA P00517 cow ETV1 2115 P50549 ETV1 human S334 3059601 PTYQRRGsLQLWQFL X -PRKACA PKACA P00517 cow eNOS 287024 P29473 NOS3 cow S1179 447884 TSRIRtQsFsLQERH X 9570 -PRKACA PKACA P00517 cow PTHR 56813 P25961 Pth1r rat S475 452060 AEIRKsWsRWTLALD X -PRKACA PKACA P00517 cow ADD1 118 P35611 ADD1 human S408 451594 REKSKkYsDVEVPAS X -PRKACA PKACA P00517 cow MYH11 24582 E9PTU4 Myh11 rat T1763 2565415 sDRVRKAtLQAEQLS Myosin_tail_1 X -PRKACA PKACA P00517 cow MYPT1 116670 Q10728 Ppp1r12a rat T697 448587 ARQSRRstQGVTLTD X 5163 -PRKACA PKACA P00517 cow SERPINA1 24648 P17475 Serpina1 rat S45 2565355 SPTYRKIsSNLADFA X -PRKACA PKACA P00517 cow Tau iso5 4137 P10636-5 MAPT human S202 447928 sGYssPGsPGtPGSR X 39357; 30505 -PRKACA PKACA P00517 cow TH 7054 P07101 TH human S71 448545 RFIGRRQsLIEDARK TOH_N X 2791 -PRKACA PKACA P00517 cow GFAP 396562 F1RR02 GFAP pig T7 449617 _MERRRVtsAARRsY Filament_head X -PRKACA PKACA P00517 cow HSP27 24471 P42930 Hspb1 rat T147 471871 RCFTRKYtLPPGVDP HSP20 X -PRKACA PKACA P00517 cow CDKN2D 1032 P55273 CDKN2D human T141 25256101 RRDARGLtPLELALQ Ank_2 X -PRKACA PKACA P00517 cow GLUD1 24399 P10860 Glud1 rat T206 2565347 EkITRRFtMELAkkG ELFV_dehydrog_N X -PRKACA PKACA P00517 cow SDPR 316384 Q66H98 Cavin2 rat S51 2565423 EEAIRDNsQVNAVTV X -PRKACA PKACA P00517 cow TRPV1 83810 O35433 Trpv1 rat S6 456215 __MEQRAsLDSEESE X -PRKACA PKACA P00517 cow Oct1 5451 P14859 POU2F1 human S385 456220 RRRKKRTsIETNIRV Homeodomain X -PRKACA PKACA P00517 cow GFAP 396562 F1RR02 GFAP pig S13 449619 VtsAARRsYVSSLET Filament_head X -PRKACA PKACA P00517 cow CFTR 1080 P13569 CFTR human S700 449978 FGEKRkNsILNPINs CFTR_R X X -PRKACA PKACA P00517 cow CACNA1S 100009585 P07293 CACNA1S rabbit S1617 452133 TFLERTNsLPPVMAN X -PRKACA PKACA P00517 cow NOLC1 64896 P41777 Nolc1 rat S627 455685 KKGEKRAssPFRRVR X -PRKACA PKACA P00517 cow CAMKK1 60341 P97756 Camkk1 rat T108 452083 PRAWRRPtIESHHVA X -PRKACA PKACA P00517 cow ACTG2 25365 P63269 Actg2 rat S34 2565383 APRAVFPsIVGRPRH Actin X -PRKACA PKACA P00517 cow LRPAP1 116565 Q99068 Lrpap1 rat S245 2565451 LDRLRKVsHQGYGPA Alpha-2-MRAP_C X -PRKACA PKACA P00517 cow PFKFB2 287019 P26285 PFKFB2 cow S467 448460 PVRMRRNsFTPLSSS X -PRKACA PKACA P00517 cow Tau iso5 4137 P10636-5 MAPT human S199 447927 GDRsGYssPGsPGtP X 29957 -PRKACA PKACA P00517 cow FGFBP1 281812 Q9MZ06 FGFBP1 cow S36 487543 NRRGSKAsADESLAL FGF-BP1 X -PRKACA PKACA P00517 cow H2B 615043 P62808 H2BC19 cow S36 449903 RKRsRKEsYSVYVYK Histone X -PRKACA PKACA P00517 cow BAD 12015 Q61337 Bad mouse S136 447862 PFRGRsRsAPPNLWA Bcl-2_BAD X 9295; 5286; 4366 -PRKACA PKACA P00517 cow Tau iso5 4137 P10636-5 MAPT human S235 449080 VVRtPPKsPSSAKSR X 20473 -PRKACA PKACA P00517 cow GSTP1 2950 P09211 GSTP1 human S185 455118 SAYVGRLsARPkLkA GST_C_3 X -PRKACA PKACA P00517 cow ADD1 118 P35611 ADD1 human S436 451595 tCsPLRHsFQkQQRE X -PRKACA PKACA P00517 cow PTRF 287710 P85125 Cavin1 rat S367 452128 ETDLLRGssPDVHTL X -PRKACA PKACA P00517 cow smMLCK 288057 D3ZFU9 Mylk rat S1819 468781 GRKSsTGsPTsPINA X -PRKACA PKACA P00517 cow PFKM 100345647 P00511 PFKM rabbit S377 4707523 AMKLRGRsFMNNWEV X -PRKACA PKACA P00517 cow DARPP-32 360616 Q6J4I0 Ppp1r1b rat T34 448047 MIRRRRPtPALLFRV DARPP-32 X 12438 -PRKACA PKACA P00517 cow profilin 1 18643 P62962 Pfn1 mouse S92 31868255 TMDLRtKstGGAPTF Profilin X -PRKACA PKACA P00517 cow CACNA1S 100009585 P07293 CACNA1S rabbit S687 452132 ERKRRKMsRGLPDKT X -PRKACA PKACA P00517 cow VASP 7408 P50552 VASP human S157 448379 EHIERRVsNAGGPPA X 3111; 84519 -PRKACA PKACA P00517 cow COL4A3 1285 Q01955 COL4A3 human S1452 1264400 GFVFTRHsQTTAIPS C4 X -PRKACA PKACA P00517 cow COL4A3 1285 Q01955 COL4A3 human S1435 1247500 LKGKRGDsGSPATWT Collagen X -PRKACA PKACA P00517 cow MYBPC3 17868 O70468 Mybpc3 mouse S273 471079 RsAFRRtsLAGAGRR X -PRKACA PKACA P00517 cow Oct7 18992 P31360 Pou3f2 mouse T361 22996304 GRKRKKRtsIEVSVK Homeodomain X -PRKACA PKACA P00517 cow NETO2 307757 C6K2K4 Neto2 rat S409 4752528 SLREKEIsADLADLS X -PRKACA PKACA P00517 cow TH iso3 7054 P07101-3 TH human S40 448545 RFIGRRQsLIEDARK TOH_N X 2791 -PRKACA PKACA P00517 cow ACTB 81822 P60711 Actb rat S33 2565375 APRAVFPsIVGRPRH Actin X -PRKACA PKACA P00517 cow ALDOA 24189 P05065 Aldoa rat S46 477796 sIAkRLQsIGTENTE Glycolytic X -PRKACA PKACA P00517 cow PKACA 25636 P27791 Prkaca rat T198 448459 RVKGRtWtLCGTPEY Pkinase X 4781; 5661 -PRKACA PKACA P00517 cow EEF1G 293725 Q68FR6 Eef1g rat S298 2565435 DEFkRKYsNEDTLSV EF1G X -PRKACA PKACA P00517 cow CACNB2 116600 Q8VGC3 Cacnb2 rat S510 451397 RSAPRSAsQAEEEPC X -PRKACA PKACA P00517 cow RYR2 6262 Q92736 RYR2 human S2808 448848 YNRTRRIsQTSQVsV X -PRKACA PKACA P00517 cow RCN2 29218 Q62703 Rcn2 rat S71 2565403 EQQRRLQsIIkKIDS EF-hand_5 X -PRKACA PKACA P00517 cow ACTN4 63836 Q9QXQ0 Actn4 rat S423 2565459 EkFRQKAsIHEAWTD Spectrin X -PRKACA PKACA P00517 cow HSP90B 301252 P34058 Hsp90ab1 rat S452 2565363 stNRRRLsELLRYHT HSP90 X -PRKACA PKACA P00517 cow MRLC2 50685 P18666 Myl12b rat S20 448595 KRPQRAtsNVFAMFD X -PRKACA PKACA P00517 cow RIL 24915 P36202 Pdlim4 rat S118 481133 sPATsRRssIsGIsL X -PMVK PMVK Q15126 human CTNNB1 1499 P35222 CTNNB1 human S184 1881579404 QLskKEAsRHAIMRs X X - Pyk2 no information Cortactin 2017 Q14247 CTTN human Y421 447702 rLPssPVyEDAAsFK X 4569 -Mapk3 ERK1 Q7M0H9 hamster GRB10 2887 Q13322 GRB10 human S476 455870 MNILGsQsPLHPSTL X 11817 -Mapk3 ERK1 Q7M0H9 hamster GRB10 2887 Q13322 GRB10 human S150 454185 PELCGPGsPPVLtPG X -Ptk2 FAK O35346 rat P130Cas 25414 Q63767 Bcar1 rat Y762 448399 EGGWMEDyDyVHLQG CAS_C X X -Ptk2 FAK O35346 rat FAK 25614 O35346 Ptk2 rat Y397 447887 SVSETDDyAEIIDEE X X 3283; 8556 -Ptk2 FAK O35346 rat P130Cas 25414 Q63767 Bcar1 rat Y263 448722 PSPATDLyQVPPGPG X X 4015 -Ptk2 FAK O35346 rat P130Cas 25414 Q63767 Bcar1 rat Y764 448400 GWMEDyDyVHLQGKE CAS_C X X -Src Src Q9WUD9 rat PDK1 81745 O55173 Pdpk1 rat Y379 447695 DEDCyGNyDNLLSQF X -Src Src Q9WUD9 rat GJA1 2697 P17302 GJA1 human Y265 447815 kDCGsQkyAyFNGCs X -Src Src Q9WUD9 rat CACNA1C 24239 P22002 Cacna1c rat Y1787 880751701 STFTPSSySSTGSNA CAC1F_C X -Src Src Q9WUD9 rat PKCD 170538 P09215 Prkcd rat Y311 447573 TPETVGIyQGFEKKT X X 2055 -Src Src Q9WUD9 rat SYN1 24949 P09951 Syn1 rat Y301 478277 VVALTkTyATAEPFI Synapsin_C X -Src Src Q9WUD9 rat PDK1 81745 O55173 Pdpk1 rat Y9 447696 ARTTSQLyDAVPIQS X -Src Src Q9WUD9 rat GJA1 24392 P08050 Gja1 rat Y265 447815 kDCGsPkyAyFNGCS X X -Src Src Q9WUD9 rat DYN2 25751 P39052 Dnm2 rat Y597 451200 NTEQRNVykDLRQIE PH X -Src Src Q9WUD9 rat GIT1 83709 Q9Z272 Git1 rat Y554 448965 ELEDDAIySVHVPAG X -Src Src Q9WUD9 rat DYN1 140694 P21575 Dnm1 rat Y597 447606 NTEQRNVykDYRQLE PH X -Src Src Q9WUD9 rat PAG 64019 Q9JM80 Pag1 rat Y314 450659 EEEISAMysSVNKPG PAG X X -Src Src Q9WUD9 rat Kv7.3 iso2 29682 O88944-2 Kcnq3 rat Y67 453408 VKRNNAKyRRIQTLI X -Src Src Q9WUD9 rat GIT1 83709 Q9Z272 Git1 rat Y293 15702201 EELAMDVyDEVDRRE GIT_SHD X -Src Src Q9WUD9 rat PAG 94212 Q3U1F9 Pag1 mouse Y314 450659 EEEISAMySSVNKPG PAG X -Src Src Q9WUD9 rat Src 6714 P12931 SRC human Y530 448235 FTstEPQyQPGENL_ X 2105 -Src Src Q9WUD9 rat DYN2 25751 P39052 Dnm2 rat Y231 451199 LLPLRRGyIGVVNRS Dynamin_M X -Src Src Q9WUD9 rat CACNA1C 24239 P22002 Cacna1c rat Y1738 880751700 LFGNHVSyYQSDSRS CAC1F_C X -Src Src Q9WUD9 rat EGFR 13649 Q01279 Egfr mouse Y871 448061 LGAEEkEyHAEGGkV PK_Tyr_Ser-Thr X 2231; 6963 -Src Src Q9WUD9 rat NMDAR2B 24410 Q00960 Grin2b rat Y1336 448166 RFMDGsPyAHMFEMP NMDAR2_C X -Src Src Q9WUD9 rat APBA1 319924 B2RUJ5 Apba1 mouse Y187 15402159 HRAEDEPyAEPyADY X -Src Src Q9WUD9 rat DYN1 140694 P21575 Dnm1 rat Y231 447605 LLPLRRGyIGVVNRS Dynamin_M X -Src Src Q9WUD9 rat SMAD1 25671 P97588 Smad1 rat S468 448363 HNPISsVs_______ X 9516; 9576; 12428; 11971; 67959; 13820; 85553; 52937 -Src Src Q9WUD9 rat PKCD 170538 P09215 Prkcd rat Y332 450077 IPDNNGTyGKIWEGS X -Src Src Q9WUD9 rat APBA1 319924 B2RUJ5 Apba1 mouse Y191 54165900 DEPyAEPyADYGGLQ X -Src Src Q9WUD9 rat APBA1 319924 B2RUJ5 Apba1 mouse Y202 23082644 GGLQEHVyEEIGDAP X X -Src Src Q9WUD9 rat PDK1 81745 O55173 Pdpk1 rat Y376 447694 SEDDEDCyGNyDNLL X -Src Src Q9WUD9 rat TACE 57027 Q9Z1K9 Adam17 rat Y702 28706300 DKKLDKQyESLSLFH X -Src Src Q9WUD9 rat GABRG2 29709 Q6PW52 Gabrg2 rat Y411 455817 LQERDEEyGyECLDG Neur_chan_memb X -Src Src Q9WUD9 rat P130Cas 25414 Q63767 Bcar1 rat Y508 448720 SVIDDGVyAVPPPAE X 4011 -Src Src Q9WUD9 rat Src 83805 Q9WUD9 Src rat Y530 448235 FTSTEPQyQPGENL_ X 2105 -Src Src Q9WUD9 rat NMDAR2B 24410 Q00960 Grin2b rat Y1472 448167 GSSNGHVyEKLssIE NMDAR2_C X 4208 -Src Src Q9WUD9 rat TACE 11491 Q9Z0F8 Adam17 mouse Y702 28706300 DKKLDKQyESLSLFH X -Src Src Q9WUD9 rat PANX1 315435 P60570 Panx1 rat Y308 54421200 KtDVLKVyEILPTFD X -Src Src Q9WUD9 rat SPTAN1 64159 P16086 Sptan1 rat Y1176 448817 AVQQQEVyGMMPRDE X -Src Src Q9WUD9 rat Kv7.3 iso2 29682 O88944-2 Kcnq3 rat Y349 453409 IQAAWRYyATNPNRL X -Src Src Q9WUD9 rat caveolin-1 25404 P41350 Cav1 rat Y14 448422 VDsEGHLyTVPIREQ X 3251 -Src Src Q9WUD9 rat GluR2 29627 P19491 Gria2 rat Y876 452173 ykEGyNVyGIEsVkI X 4027; 3921 -Src Src Q9WUD9 rat FAK 25614 O35346 Ptk2 rat Y928 447966 DRSNDKVyENVTGLV Focal_AT X 3284 -Src Src Q9WUD9 rat EGFR 24329 Q9QX70 Egfr rat Y870 448061 LGAEEKEyHAEGGKV PK_Tyr_Ser-Thr X 2231; 6963 -Src Src Q9WUD9 rat G-alpha t1 281794 P04695 GNAT1 cow Y142 470102 CFDRASEyQLNDSAG G-alpha X -Src Src Q9WUD9 rat GABRG2 29709 Q6PW52 Gabrg2 rat Y413 455818 ERDEEyGyECLDGKD Neur_chan_memb X -Rock1 ROCK1 Q63644 rat TSC2 24855 P49816 Tsc2 rat T1203 19075303 EILVRRPtGNTSWLM X -Rock1 ROCK1 Q63644 rat IRS1 25467 P35570 Irs1 rat S635 447507 yMPMsPKsVsAPQQI X 2388 -Rock1 ROCK1 Q63644 rat IRS1 16367 P35569 Irs1 mouse S302 450190 TRRSRtEsITAtsPA X 2384; 2491 -Rock1 ROCK1 Q63644 rat IRS1 16367 P35569 Irs1 mouse S635 447507 yMPMsPKsVsAPQQI X 2388 -Rock1 ROCK1 Q63644 rat IRS1 25467 P35570 Irs1 rat S302 450190 TRRSRTEsITATsPA X 2384; 2491 -Rock1 ROCK1 Q63644 rat LIMK2 29524 P53670 Limk2 rat T505 448683 SDRKKRYtVVGNPYW PK_Tyr_Ser-Thr X 3841 -Rock1 ROCK1 Q63644 rat IRS1 16367 P35569 Irs1 mouse S632 447506 NGDyMPMsPKsVsAP X 2388 -Rock1 ROCK1 Q63644 rat IRS1 25467 P35570 Irs1 rat S632 447506 NGDyMPMsPKsVsAP X 2388 -Rock1 ROCK1 Q63644 rat MYPT1 116670 Q10728 Ppp1r12a rat T855 452075 PREKRRstGVSFWTQ X 4563 -Rock1 ROCK1 Q63644 rat MYPT1 116670 Q10728 Ppp1r12a rat T697 448587 ARQSRRstQGVTLTD X X 5163 -DYRK1A DYRK1A Q13627 human Tau iso8 4137 P10636-8 MAPT human S199 447927 GDRsGyssPGsPGtP X X 29957 -DYRK1A DYRK1A Q13627 human RCAN1 54720 Q9JHG6 Rcan1 mouse T246 21511701 QTRRPEYtPIHLS__ X -DYRK1A DYRK1A Q13627 human Tau iso8 4137 P10636-8 MAPT human S396 449081 GAEIVyKsPVVsGDt X X 9632 -DYRK1A DYRK1A Q13627 human Tau iso8 4137 P10636-8 MAPT human S404 449082 PVVsGDtsPRHLsNV X X 35834; 20194; 98523; 91600; 49562 -DYRK1A DYRK1A Q13627 human TRAF3 22031 Q60803 Traf3 mouse S29 23154950 QPDRGAGsVLVPEQG X X -DYRK1A DYRK1A Q13627 human eIF2B-epsilon 192234 Q64350 Eif2b5 rat S539 449906 ELDsRAGsPQLDDIR X -DYRK1A DYRK1A Q13627 human TRAF3 7187 Q13114 TRAF3 human S75 1875793002 CGHRFCEsCMAALLS X -DYRK1A DYRK1A Q13627 human SF2 689890 NP_001103022 Srsf1 rat S234 468704 sPRRsRGsPRYsPRH X -DYRK1A DYRK1A Q13627 human MEF2D 4209 Q14814 MEF2D human S251 3196577 NkVIPAksPPPPtHS X X -DYRK1A DYRK1A Q13627 human amphiphysin 218038 Q7TQF7 Amph mouse S293 465542 PAPVRPRsPsQtRKG X -DYRK1A DYRK1A Q13627 human CCNL2 81669 Q96S94 CCNL2 human S369 471000 AKkAkADsPVNGLPK X -DYRK1A DYRK1A Q13627 human CCND1 595 P24385 CCND1 human T286 447839 EEVDLACtPtDVRDV X X 3300; 94159 -DYRK1A DYRK1A Q13627 human amphiphysin 273 P49418 AMPH human S295 465543 PARPRsPsQTRKGPP X -DYRK1A DYRK1A Q13627 human FOXO1A 2308 Q12778 FOXO1 human S329 448076 stIsGRLsPIMtEQD X -DYRK1A DYRK1A Q13627 human PLK2 10769 Q9NYY3 PLK2 human S358 1883594400 VPDFHLSsPAKNFFK X -DYRK1A DYRK1A Q13627 human CDKL5 6792 O76039 CDKL5 human S308 15719610 RLLDRsPsRSAKRkP X X -DYRK1A DYRK1A Q13627 human CCNL2 81669 Q96S94 CCNL2 human S330 7322508 LDGtsGFsPAPKLVE X -DYRK1A DYRK1A Q13627 human SNCA 6622 P37840 SNCA human S87 449948 ktVEGAGsIAAATGF Synuclein X X -DYRK1A DYRK1A Q13627 human DYN1 1759 Q05193 DNM1 human S857 455277 AsPSRPEsPRPPFDL X X -DYRK1A DYRK1A Q13627 human RCAN1 1827 P53805 RCAN1 human S167 456023 FLIsPPAsPPVGWKQ Calcipressin X -DYRK1A DYRK1A Q13627 human Tau iso8 4137 P10636-8 MAPT human S202 447928 sGyssPGsPGtPGsR X 39357; 30505 -DYRK1A DYRK1A Q13627 human CASP9 12371 Q8C3Q9 Casp9 mouse T163 449563 PEVLRPEtPRPVDIG X X -DYRK1A DYRK1A Q13627 human TRAF3 7187 Q13114 TRAF3 human T29 23154950 HTDRSAGtPVFVPEQ X X -DYRK1A DYRK1A Q13627 human NMDAR2A 24409 Q00959 Grin2a rat S1048 36747000 NRTHSLKsPRYLPEE NMDAR2_C X X -DYRK1A DYRK1A Q13627 human amphiphysin 273 P49418 AMPH human T310 465544 VPPLPKVtPtKELQQ X -DYRK1A DYRK1A Q13627 human Tau iso8 4137 P10636-8 MAPT human T217 449078 sRtPsLPtPPtREPK X X 33134; 51625 -DYRK1A DYRK1A Q13627 human RCAN1 1827 P53805 RCAN1 human T247 21511701 QtRRPEYtPIHLS__ X -DYRK1A DYRK1A Q13627 human POLR2A 5430 P24928 POLR2A human S1616 450204 TPQSPSysPtsPsYS RNA_pol_Rpb1_R X X 4735; 13499; 13546; 31262 -DYRK1A DYRK1A Q13627 human GLI1 2735 P08151 GLI1 human S408 41595600 GPLPRAPsISTVEPk X -DYRK1A DYRK1A Q13627 human SF2 689890 NP_001103022 Srsf1 rat S238 468705 sRGsPRYsPRHsRsR X -DYRK1A DYRK1A Q13627 human DYRK1A 1859 Q13627 DYRK1A human S529 475065 SNSGRARsDPtHQHR X -DYRK1A DYRK1A Q13627 human SF2 689890 NP_001103022 Srsf1 rat S227 2303915 NSRsRsYsPRRsRGs X -DYRK1A DYRK1A Q13627 human NFAT2 4772 O95644 NFATC1 human S261 15412721 ARssRPAsPCNKRKY X -DYRK1A DYRK1A Q13627 human amphiphysin 273 P49418 AMPH human S293 465542 PAPARPRsPsQTRKG X X -DYRK1A DYRK1A Q13627 human SF3B1 23451 O75533 SF3B1 human T273 460653 AtPGRGDtPGHAtPG X -DYRK1A DYRK1A Q13627 human GYS1 100008660 P13834 GYS1 rabbit S641 448237 YRYPRPAsVPPsPSL Glycogen_syn X -DYRK1A DYRK1A Q13627 human NFAT2 4772 O95644 NFATC1 human S409 63036600 LsPTSYMsPTLPALD X -DYRK1A DYRK1A Q13627 human Tau iso8 4137 P10636-8 MAPT human T212 447934 tPGsRsRtPsLPtPP X X -DYRK1A DYRK1A Q13627 human SIRT1 93759 Q923E4 Sirt1 mouse T522 6006905 HLSELPPtPLHIsED X X -DYRK1A DYRK1A Q13627 human CCNL2 81669 Q96S94 CCNL2 human S338 11263900 PAPKLVEsPKEGKGs X -DYRK1A DYRK1A Q13627 human LIN52 91750 Q52LA3 LIN52 human S28 4758466 FEKLDRAsPDLWPEQ LIN52 X X -DYRK1A DYRK1A Q13627 human POLR2A 5430 P24928 POLR2A human S1619 447616 SPSysPtsPsYSPTS RNA_pol_Rpb1_R X X 4735; 13523; 13546; 67221 -DYRK1A DYRK1A Q13627 human SPRY2 10253 O43597 SPRY2 human T75 4145505 KPAPRPStQHkHERL X X -DYRK1A DYRK1A Q13627 human ID2 15902 P41136 Id2 mouse T27 4706880 LGISRsKtPVDDPMS X -DYRK1A DYRK1A Q13627 human NFAT2 4772 O95644 NFATC1 human S403 41453279 WAkPKPLsPTSYMsP X -DYRK1A DYRK1A Q13627 human p53 7157 P04637 TP53 human S15 447490 PsVEPPLsQEtFsDL P53_TAD X X 4030; 9235; 9284; 9286; 8695; 8514; 82530; 56979 -DYRK1A DYRK1A Q13627 human CCND3 12445 P30282 Ccnd3 mouse T283 452160 QGPSQTStPTDVTAI X 53966 -DYRK1A DYRK1A Q13627 human Tau iso8 4137 P10636-8 MAPT human T205 447933 ssPGsPGtPGsRsRt X X 25377; 43964; 53001; 49561; 20060; 33032; 30505; 20739; 98160 -DYRK1A DYRK1A Q13627 human SF3B1 23451 O75533 SF3B1 human T434 460652 PARkLtAtPtPLGGM SF3b1 X X -DYRK1A DYRK1A Q13627 human Tau iso8 4137 P10636-8 MAPT human S422 449083 GsIDMVDsPQLAtLA X X -DYRK1A DYRK1A Q13627 human TRAF3 7187 Q13114 TRAF3 human S9 5274284 ESSKKMDsPGALQTN X -DYRK1A DYRK1A Q13627 human NFAT2 4772 O95644 NFATC1 human S278 41453273 NGRQPPYsPHHsPTP X -DYRK1A DYRK1A Q13627 human amphiphysin 273 P49418 AMPH human T312 465545 PLPKVtPtKELQQEN X -HIPK1 HIPK1 Q86Z02 human MECP2 4204 P51608 MECP2 human S216 18012096 VkRVLEKsPGkLLVk X X -HIPK1 HIPK1 Q86Z02 human MECP2 4204 P51608 MECP2 human S80 452713 AVPEAsAsPKQRRsI X -HIPK1 HIPK1 Q86Z02 human PAGE4 9506 O60829 PAGE4 human T51 3913886 PGQEREGtPPIEERK GAGE X -HIPK1 HIPK1 Q86Z02 human CREB 1385 P16220 CREB1 human S257 14159739 PGVVMAssPALPTQP X -Fgfr1 FGFR1 P16092 mouse FGFR1 2260 P11362 FGFR1 human Y653 447918 RDIHHIDyykKTTNG PK_Tyr_Ser-Thr X 3471; 3476; 52928 -Fgfr1 FGFR1 P16092 mouse FGFR1 2260 P11362 FGFR1 human Y583 448702 RRPPGLEyCyNPsHN PK_Tyr_Ser-Thr X -Fgfr1 FGFR1 P16092 mouse FGFR1 2260 P11362 FGFR1 human Y585 448703 PPGLEyCyNPsHNPE PK_Tyr_Ser-Thr X -Fgfr1 FGFR1 P16092 mouse FGFR1 2260 P11362 FGFR1 human Y654 447919 DIHHIDyykKTTNGR PK_Tyr_Ser-Thr X 3471; 3476; 52928 -Fgfr1 FGFR1 P16092 mouse NLGN1 192167 Q99K10 Nlgn1 mouse Y782 1008111 RTACPPDyTLAMRRS X -Fgfr1 FGFR1 P16092 mouse FGFR1 2260 P11362 FGFR1 human Y605 448769 KDLVsCAyQVARGME PK_Tyr_Ser-Thr X -Fgfr1 FGFR1 P16092 mouse FGFR1 2260 P11362 FGFR1 human Y463 448641 MLAGVSEyELPEDPR X -Fgfr1 FGFR1 P16092 mouse FGFR3 2261 P22607 FGFR3 human Y599 464763 KDLVsCAyQVARGME PK_Tyr_Ser-Thr X -NEK3 NEK3 P51956 human NEK3 4752 P51956 NEK3 human T165 57829902 FACTYVGtPYYVPPE Pkinase X -NEK3 NEK3 P51956 human SNAP29 9342 O95721 SNAP29 human S105 56651951 MDQDLkIsQkHINsI V-SNARE_C X -Prkce PKCE P09216 rat PLCB3 29322 Q99JE6 Plcb3 rat S1105 448448 LDRKRNNsISEAKTR PLC-beta_C X 2484 -Prkce PKCE P09216 rat K8 16691 P11679 Krt8 mouse S9 484004 sIRVTQKsYkMstsG Keratin_2_head X -Prkce PKCE P09216 rat SCN10A Q62968 Scn10a rat S1452 25126701 NAMKKLGsKKPQKPI X -Prkce PKCE P09216 rat TRPV1 83810 O35433 Trpv1 rat S800 450017 VPLLRDAsTRDRHAT X X -Prkce PKCE P09216 rat Kv3.1 25327 P25122 Kcnc1 rat S503 464642 LEINRADsKLNGEVA X -Prkce PKCE P09216 rat TRPV1 83810 O35433 Trpv1 rat S502 450016 YFLQRRPsLKSLFVD Ion_trans X -Prkce PKCE P09216 rat K18 3875 P05783 KRT18 human S53 447734 IsVsrstsFrGGMGs X -Prkce PKCE P09216 rat K8 16691 P11679 Krt8 mouse S24 448538 PrAFssRsFtsGPGA Keratin_2_head X -Prkce PKCE P09216 rat GJA1 24392 P08050 Gja1 rat S368 447813 QRPssRAssRAssRP X 3511; 52559 -Prkce PKCE P09216 rat G-gamma 12 14701 Q9DAS9 Gng12 mouse S2 447876 ______MssktAstN X -Prkce PKCE P09216 rat GJA1 24392 P08050 Gja1 rat S262 450694 sPskDCGsPkyAyFN X -Mapk12 P38G Q63538 rat DLG1 25252 Q62696 Dlg1 rat S122 3195032 VLPSERIsPQVPNEV MAGUK_N_PEST X -Mapk12 P38G Q63538 rat SNTA1 6640 Q13424 SNTA1 human S193 469673 GWDsPPAsPLQRQPs X X -Mapk12 P38G Q63538 rat DLG1 1739 Q12959 DLG1 human S122 3195032 tPPQEHIsPQItNEV MAGUK_N_PEST X -Mapk12 P38G Q63538 rat DLG1 1739 Q12959 DLG1 human T209 35547401 VNTDSLEtPTYVNGT MAGUK_N_PEST X -Mapk12 P38G Q63538 rat DLG1 25252 Q62696 Dlg1 rat T209 35547401 VNTDSLEtPTYVNGT MAGUK_N_PEST X -Mapk12 P38G Q63538 rat DLG1 1739 Q12959 DLG1 human S158 2024309 FVsHsHIsPIKPTEA MAGUK_N_PEST X -Mapk12 P38G Q63538 rat DLG1 25252 Q62696 Dlg1 rat S442 5931300 YLGQTPAsPARYsPI PDZ_assoc X -Mapk12 P38G Q63538 rat DLG1 25252 Q62696 Dlg1 rat S447 15176604 PAsPARYsPISKAVL PDZ_assoc X -Mapk12 P38G Q63538 rat DLG1 25252 Q62696 Dlg1 rat S158 2024309 FVSHSHIsPIKPTEA MAGUK_N_PEST X -Mapk12 P38G Q63538 rat SNTA1 6640 Q13424 SNTA1 human S201 4729592 PLQRQPssPGPtPRN X X -Mapk12 P38G Q63538 rat DLG1 25252 Q62696 Dlg1 rat S431 4749386 QSVDNHVsPSSYLGQ PDZ_assoc X -NEK11 NEK11 Q8NG66 human CDC25A 993 P30304 CDC25A human S82 450248 GssEstDsGFCLDsP X X -NEK11 NEK11 Q8NG66 human BLM 641 P54132 BLM human S338 4700251 kEDVLSTskDLLskP BLM_N X X -NEK11 NEK11 Q8NG66 human CDC25A 993 P30304 CDC25A human S88 458298 DsGFCLDsPGPLDSK M-inducer_phosp X X -NEK11 NEK11 Q8NG66 human CDC25A 993 P30304 CDC25A human S79 450247 QRMGssEstDsGFCL X -PIK3R1 PIK3R1 P27986 human Akt1 207 P31749 AKT1 human S473 447855 RPHFPQFsysAsGtA Pkinase_C X 9271; 3787; 4060; 4051; 5102; 4058; 2336; 2337; 4075; 4070; 5012; 4071; 92982; 5315; 9563; 9018; 12694; 52240; 11962; 15116; 88106; 26580; 68035; 31957; 23430; 20235 -Plk1 PLK1 Q07832 mouse IRS2 384783 P81122 Irs2 mouse S1098 3217320 TsGLKRLsLMDQVSG X X -Plk1 PLK1 Q07832 mouse CELSR1 12614 O35161 Celsr1 mouse S2741 27446069 KKLQLDDsATTRATL X -Plk1 PLK1 Q07832 mouse CELSR1 12614 O35161 Celsr1 mouse S2752 31884511 RATLLtRsLNCNNTY X -Plk1 PLK1 Q07832 mouse CELSR1 12614 O35161 Celsr1 mouse T2750 41159600 TTRATLLtRsLNCNN X -Plk1 PLK1 Q07832 mouse HSF1 15499 P38532 Hsf1 mouse S415 455264 SALLDLFsPSVTMPD Vert_HS_TF X X -Plk1 PLK1 Q07832 mouse IRS1 3667 P35568 IRS1 human S24 455604 GYLRKPKsMHKRFFV PH X -Plk1 PLK1 Q07832 mouse TPT1 22070 P63028 Tpt1 mouse S64 3146607 PEGEGTEsTVVTGVD TCTP X -Plk1 PLK1 Q07832 mouse RIPK3 56532 Q9QZL0 Ripk3 mouse S369 27928505 ERQAQDTsVGPAtPA X -Plk1 PLK1 Q07832 mouse TPT1 22070 P63028 Tpt1 mouse S46 476067 TEGAIDDsLIGGNAs TCTP X 5251 -Plk1 PLK1 Q07832 mouse CDK5RAP2 214444 Q8K389 Cdk5rap2 mouse S608 41285495 KALQEQLsEIRSREE X -Plk1 PLK1 Q07832 mouse IRS2 384783 P81122 Irs2 mouse S556 470895 GRPYRRVsGDGAQDL X X -Ripk4 ANKRD3 Q9ERK0 mouse IRF6 54139 P97431 Irf6 mouse S90 56649936 LRCALNKsREFNLMY IRF X -Ripk4 ANKRD3 Q9ERK0 mouse IRF6 54139 P97431 Irf6 mouse S424 27451041 GsVRLQIstPDIKDN X X -Ripk4 ANKRD3 Q9ERK0 mouse IRF6 54139 P97431 Irf6 mouse S413 18911095 FSGDFTRsFDSGsVR X X -Prkd1 PRKD1 Q62101 mouse HDAC7 51564 Q8WUI4 HDAC7 human S486 452459 RPLsRAQssPAAPAs X 3424 -Prkd1 PRKD1 Q62101 mouse PRKD1 18760 Q62101 Prkd1 mouse S744 448589 ARIIGEksFRRsVVG Pkinase X 2054 -Prkd1 PRKD1 Q62101 mouse PRKD2 101540 Q8BZ03 Prkd2 mouse S873 448800 QGLAERIsIL_____ X -Prkd1 PRKD1 Q62101 mouse TNNI3 29248 P23693 Tnni3 rat S23 448423 PAPVRRRssANYRAY Troponin-I_N X X 4004 -Prkd1 PRKD1 Q62101 mouse PRKD1 5587 Q15139 PRKD1 human S910 447632 KALGERVsIL_____ X 2051; 75148 -Prkd1 PRKD1 Q62101 mouse PRKD1 18760 Q62101 Prkd1 mouse S748 448590 GEksFRRsVVGtPAy Pkinase X 2054 -Prkd1 PRKD1 Q62101 mouse HDAC7 51564 Q8WUI4 HDAC7 human S155 455620 FPLRKtVsEPNLkLR X 3443 -Prkd1 PRKD1 Q62101 mouse PRKD1 18760 Q62101 Prkd1 mouse S916 447632 KALSERVsIL_____ X X 2051; 75148 -Prkd1 PRKD1 Q62101 mouse HDAC7 51564 Q8WUI4 HDAC7 human S358 455621 WPLsRtRsEPLPPsA X -Prkd1 PRKD1 Q62101 mouse MYBPC3 17868 O70468 Mybpc3 mouse S302 471081 sLLKKRDsFRRDskL X X -Prkd1 PRKD1 Q62101 mouse PRKD1 18760 Q62101 Prkd1 mouse S203 449896 GVRRRRLsNVsLTGL X -Prkd1 PRKD1 Q62101 mouse TNNI3 29248 P23693 Tnni3 rat S24 448424 APVRRRssANYRAYA Troponin-I_N X X 4004 -PGK1 PGK1 P00558 human beclin 1 8678 Q14457 BECN1 human S30 7446159 QPLkLDTsFkILDRV X X 54101; 35955 -PGK1 PGK1 P00558 human VASP 7408 P50552 VASP human S239 448380 GAKLRKVsKQEEASG X 3114; 37565 -PGK1 PGK1 P00558 human PRAS40 84335 Q96B36 AKT1S1 human T246 470067 LPRPRLNtsDFQkLK PRAS X X 2640; 2997; 32263; 13175; 60202 -PGK1 PGK1 P00558 human PDHK1 5163 Q15118 PDK1 human T338 54390604 LFNYMyStAPRPRVE HATPase_c X -PGK1 PGK1 P00558 human PGK1 5230 P00558 PGK1 human Y324 5233200 GPESSkkyAEAVTRA PGK X X -Met Met P16056 mouse Met 17295 P16056 Met mouse Y1233 448471 DMyDKEyysVHNKtG PK_Tyr_Ser-Thr X 4091; 3129; 3126; 3077; 12468; 4033; 98954 -Met Met P16056 mouse GAB1 14388 Q9QYY0 Gab1 mouse Y407 447946 DASsQDCyDIPRtFP X -Met Met P16056 mouse GAB1 14388 Q9QYY0 Gab1 mouse Y628 447948 KGDKQVEyLDLDLDs X 3231; 3233 -Met Met P16056 mouse GAB1 14388 Q9QYY0 Gab1 mouse Y373 447945 ASDtDSSyCIPPPAG X -Met Met P16056 mouse GAB1 14388 Q9QYY0 Gab1 mouse Y285 449801 TEADGELyTFNTPSG X -Met Met P16056 mouse RALGDS 19730 Q03385 Ralgds mouse Y752 59087905 DVDNGNMyKSILVTS RA X -Met Met P16056 mouse GAB1 14388 Q9QYY0 Gab1 mouse Y448 449791 GEELDENyVPMNPNs X -Met Met P16056 mouse GAB1 14388 Q9QYY0 Gab1 mouse Y590 449792 SHDSEENyVPMNPNL X -Met Met P16056 mouse GAB1 14388 Q9QYY0 Gab1 mouse Y473 447947 EPIQEPNyVPMtPGT X -Met Met P16056 mouse GAB1 14388 Q9QYY0 Gab1 mouse Y660 447949 MADERVDyVVVDQQK X 12745 -Met Met P16056 mouse GAB1 14388 Q9QYY0 Gab1 mouse Y307 447944 MRHVsISyDIPPtPG X 3234 -Met Met P16056 mouse Met 17295 P16056 Met mouse Y1232 448470 rDMyDKEyysVHNKt PK_Tyr_Ser-Thr X 4091; 3129; 3126; 3077; 12468; 4033; 98954 -JAK2 JAK2 O60674 human GTF2I iso2 2969 P78347-2 GTF2I human Y248 448250 EESEDPDyyQyNIQG X X -JAK2 JAK2 O60674 human beclin 1 8678 Q14457 BECN1 human Y333 1874101912 QRYRLVPyGNHsYLE APG6 X -JAK2 JAK2 O60674 human PAK1 5058 Q13153 PAK1 human Y285 487520 QGASGTVyTAMDVAT Pkinase X X -JAK2 JAK2 O60674 human PRMT5 10419 O14744 PRMT5 human Y307 18545700 FAKGyEDyLQsPLQP PRMT5 X X -JAK2 JAK2 O60674 human STAP2 55620 Q9UGK3 STAP2 human Y250 478353 PFLLDEDyEKVLGyV X -JAK2 JAK2 O60674 human GRB2 2885 P62993 GRB2 human Y209 448512 TGMFPRNyVtPVNrN X -JAK2 JAK2 O60674 human EPOR 13857 P14753 Epor mouse Y503 449885 SEPLHPGyVACS___ X -JAK2 JAK2 O60674 human PRLR 5618 P16471 PRLR human S349 451641 YLDPDTDsGRGSCDs X -JAK2 JAK2 O60674 human EZH2 2146 Q15910 EZH2 human Y641 31825502 kNEFISEyCGEIISQ SET X X -JAK2 JAK2 O60674 human STAT5A 6776 P42229 STAT5A human Y694 447767 LAkAVDGyVkPQIkQ X 9365; 9356; 9359; 9351; 4322; 9314; 3939; 40284; 5387; 14603; 66740; 51879; 72712 -JAK2 JAK2 O60674 human PPDPF 79144 Q9H3Y8 PPDPF human Y17 1883583900 LVATHDyyRRRLGst X X -JAK2 JAK2 O60674 human CCR2 729230 P41597 CCR2 human Y139 448635 ILLTIDRyLAIVHAV 7tm_1 X -JAK2 JAK2 O60674 human JMJD1A 55818 Q9Y4C1 KDM3A human Y1101 462537 PDLGPKMyNAyGLIT X -JAK2 JAK2 O60674 human STAT5B 20851 P42232 Stat5b mouse Y699 448198 TAkAADGyVKPQIKQ X 9365; 9356; 9359; 9351; 4322; 9314; 3939; 40284; 5387; 14603; 66740; 51879; 72712 -JAK2 JAK2 O60674 human BRD4 23476 O60885 BRD4 human Y98 1874101904 kLNLPDyykIIKtPM Bromodomain X X -JAK2 JAK2 O60674 human JAK2 3717 O60674 JAK2 human Y570 451494 VRREVGDyGQLHETE PK_Tyr_Ser-Thr X X -JAK2 JAK2 O60674 human PAK1 5058 Q13153 PAK1 human Y153 463955 tDksAEDyNssNALN X X -JAK2 JAK2 O60674 human GRB2 2885 P62993 GRB2 human Y52 7388002 DGFIPkNyIEMkPHP X -JAK2 JAK2 O60674 human SOCS3 9021 O14543 SOCS3 human Y221 450447 IREFLDQyDAPL___ X -JAK2 JAK2 O60674 human STAT3 6774 P40763 STAT3 human Y705 448192 DPGsAAPyLktKFIC X X 4093; 9145; 4324; 9131; 9138; 4323; 4074; 4113; 48313; 20977; 25023; 8119; 52075; 52527; 73533; 61958; 73452; 16185; 74309 -JAK2 JAK2 O60674 human CTLA-4 12477 P09793 Ctla4 mouse Y201 450897 SPLTTGVyVKMPPTE X X -JAK2 JAK2 O60674 human PRMT5 10419 O14744 PRMT5 human Y304 18545701 yELFAKGyEDyLQsP PRMT5 X X -JAK2 JAK2 O60674 human STAP2 55620 Q9UGK3 STAP2 human Y22 11500606 GVLPSHYyESFLEKK PH X -JAK2 JAK2 O60674 human GAB2 9846 Q9UQC2 GAB2 human Y643 450913 tsDEKVDyVQVDKEK X X -JAK2 JAK2 O60674 human EPOR 13857 P14753 Epor mouse Y453 455531 PTPPHLKyLyLVVSD X -JAK2 JAK2 O60674 human ASK1 4217 Q99683 MAP3K5 human Y718 458209 IPERDSRySQPLHEE Pkinase X X -JAK2 JAK2 O60674 human EPOR 13857 P14753 Epor mouse Y455 455532 PPHLKyLyLVVSDSG X -JAK2 JAK2 O60674 human ARHGEF1 9138 Q92888 ARHGEF1 human Y738 13421400 WDQEAQIyELVAQTV PH_16 X X -JAK2 JAK2 O60674 human SOCS3 12702 O35718 Socs3 mouse Y204 450446 VNGHLDSyEKVTQLP X -JAK2 JAK2 O60674 human STAT3 20848 P42227 Stat3 mouse Y705 448192 DPGsAAPyLktkFIC X 4093; 9145; 4324; 9131; 9138; 4323; 4074; 4113; 48313; 20977; 25023; 8119; 52075; 52527; 73533; 61958; 73452; 16185; 74309 -JAK2 JAK2 O60674 human H3 8350 P68431 H3C1 human Y41 10897613 GVkkPHryrPGtVAL Histone X X -JAK2 JAK2 O60674 human GRB2 2885 P62993 GRB2 human Y37 7388001 EECDQNWykAELNGk SH3_1 X -JAK2 JAK2 O60674 human CBP 12914 P45481 Crebbp mouse Y1126 55377870 QLLGIPDyFDIVKNP Bromodomain X X -JAK2 JAK2 O60674 human GRB2 2885 P62993 GRB2 human Y7 478849 _MEAIAkyDFkATAD SH3_1 X -JAK2 JAK2 O60674 human ATOH1 11921 P48985 Atoh1 mouse Y78 386186604 CTARAAQyLLHSPEL X -JAK2 JAK2 O60674 human JAK2 3717 O60674 JAK2 human S523 465671 GVsDVPtsPTLQRPT X X -JAK2 JAK2 O60674 human PPDPF 79144 Q9H3Y8 PPDPF human Y16 1883583902 sLVATHDyyRRRLGs X X -JAK2 JAK2 O60674 human STAP2 55620 Q9UGK3 STAP2 human Y322 3974222 GDGPAVDyENQDVAS X -JAK2 JAK2 O60674 human PRLR 19116 Q08501 Prlr mouse Y532 3188101 VPETSKEyAKVSGVT X -JAK2 JAK2 O60674 human TET2 54790 Q6N021 TET2 human Y1964 1870020001 HETSEPTyLRFIKSL X X -JAK2 JAK2 O60674 human Chk2 11200 O96017 CHEK2 human Y156 1877718908 EVGPKNSyIAYIEDH FHA X X -JAK2 JAK2 O60674 human PBK 55872 Q96KB5 PBK human Y74 473837 NPICNDHyRsVyQkR Pkinase X X -JAK2 JAK2 O60674 human STAP2 55620 Q9UGK3 STAP2 human Y310 6155352 LPNQEENyVTPIGDG X -JAK2 JAK2 O60674 human PRMT5 10419 O14744 PRMT5 human Y297 18545702 NRPPPNAyELFAKGy PRMT5 X X -JAK2 JAK2 O60674 human STAT5A 443419 P42231 STAT5A sheep Y694 447767 LAKAVDGyVKPQIKQ X 9365; 4322; 3939; 5387; 14603; 66740; 72712 -JAK2 JAK2 O60674 human ERK2 5594 P28482 MAPK1 human Y187 447594 HtGFLtEyVAtRWyr Pkinase X 9106; 4370; 4374; 9101; 4375; 4376; 4377; 3510; 5726; 88569; 13214; 13148; 70235; 9488; 89967; 8544; 14196; 14227; 14095; 14474; 75165; 98168; 33370; 54240; 15892; 45899; 55088; 9524; 69217; 48735 -JAK2 JAK2 O60674 human JAK2 16452 Q62120 Jak2 mouse Y1007 448407 VLPQDKEyyKVKEPG PK_Tyr_Ser-Thr X 3771; 3776; 4406; 66245; 32901 -JAK2 JAK2 O60674 human SMARCA3 100009232 Q95216 HLTF rabbit Y195 18707503 SGRAGPSySMPVHAA X X -JAK2 JAK2 O60674 human JAK2 3717 O60674 JAK2 human Y119 470132 VLYRIRFyFPRWYCS FERM_F1 X -JAK2 JAK2 O60674 human PDHA1 5160 P08559 PDHA1 human Y301 454753 MsDPGVsyRtREEIQ E1_dh X -JAK2 JAK2 O60674 human SOCS3 9021 O14543 SOCS3 human Y204 450446 VNGHLDSyEkVTQLP X -JAK2 JAK2 O60674 human PDHK1 5163 Q15118 PDK1 human Y243 462384 ARRLCDLyyINSPEL X -JAK2 JAK2 O60674 human BRD4 23476 O60885 BRD4 human Y97 1874101902 VkLNLPDyykIIKtP Bromodomain X X -JAK2 JAK2 O60674 human ERK1 5595 P27361 MAPK3 human Y204 447543 HtGFLtEyVAtRWyr Pkinase X 9106; 4370; 4374; 9101; 4375; 4376; 4377; 3510; 5726; 88569; 13214; 13148; 70235; 9488; 89967; 8544; 14196; 14227; 14095; 14474; 75165; 98168; 33370; 54240; 15892; 45899; 55088; 9524; 69217; 48735 -JAK2 JAK2 O60674 human PAK1 5058 Q13153 PAK1 human Y201 487519 PEHtKsVyTRsVIEP X X -JAK2 JAK2 O60674 human TET2 54790 Q6N021 TET2 human Y1939 1870020000 CEKYGPDyVPQKSHG X X -JAK2 JAK2 O60674 human STAT1 6772 P42224 STAT1 human Y701 447754 DGPkGtGyIktELIs X X 9174; 9167; 5375; 25685; 8062; 8183; 8009; 55603; 7649; 25809; 57216; 45118; 39205; 88845; 88211; 76285; 90145 -CDK4 CDK4 P11802 human Rb 5925 P06400 RB1 human S780 447978 strPPtLsPIPHIPr Rb_C X X 9307; 3590; 8180 -CDK4 CDK4 P11802 human TFEB 7942 P19484 TFEB human S467 4785142 KASsRRssFsMEEGD DUF3371 X -CDK4 CDK4 P11802 human C/EBP-alpha 12606 P53566 Cebpa mouse S193 1868113505 PPPHPHAsPAHLAAP X X -CDK4 CDK4 P11802 human Rb-like 2 5934 Q08999 RBL2 human T401 449723 SKALRIStPLtGVRY X -CDK4 CDK4 P11802 human TFEB 7942 P19484 TFEB human T331 3181634 RVHGLPttsPsGMNM DUF3371 X -CDK4 CDK4 P11802 human FOXM1 2305 Q08050 FOXM1 human T510 22648003 EDSSQsPtPRPKKSy X -CDK4 CDK4 P11802 human CDC25A 993 P30304 CDC25A human S40 63080405 ASAAGGLsPVTNLTV X -CDK4 CDK4 P11802 human FOXO1A 2308 Q12778 FOXO1 human S249 471071 EGGkSGksPrRrAAs X X -CDK4 CDK4 P11802 human p73 7161 O15350 TP73 human T86 449047 AASASPYtPEHAASV X -CDK4 CDK4 P11802 human DNMT1 1786 P26358 DNMT1 human S127 3189388 VGMADANsPPKPLsk X -CDK4 CDK4 P11802 human MEF2D 4209 Q14814 MEF2D human S98 470518 KGFNGCDsPEPDGED HJURP_C X -CDK4 CDK4 P11802 human FOXM1 2305 Q08050 FOXM1 human T611 451437 ETLPISstPSkSVLP X X -CDK4 CDK4 P11802 human TSC2 7249 P49815 TSC2 human S1452 3191272 LPSssPRsPsGLrPr X X -CDK4 CDK4 P11802 human FOXM1 2305 Q08050 FOXM1 human S508 22648001 sWEDSSQsPtPRPKK X -CDK4 CDK4 P11802 human EGLN2 112398 Q96KS0 EGLN2 human S130 31088285 EDGGDAPsPsKRPWA X -CDK4 CDK4 P11802 human E2A 6929 P15923 TCF3 human S245 455906 PMLGGGSsPLPLPPG X -CDK4 CDK4 P11802 human WDR77 79084 Q9BQA1 WDR77 human S264 17797201 CVTGLVFsPHSVPFL X -CDK4 CDK4 P11802 human VCP 7415 P55072 VCP human S664 7435526 LkANLRksPVAkDVD X -CDK4 CDK4 P11802 human DNMT1 1786 P26358 DNMT1 human S954 452278 TFNIKLSsPVkRPRk BAH X -CDK4 CDK4 P11802 human TFEB 7942 P19484 TFEB human S211 25529700 LVGVTSSsCPADLTQ X 37681 -CDK4 CDK4 P11802 human Rb 5925 P06400 RB1 human T356 447981 DsFEtQRtPRksNLD X 81403; 99158 -CDK4 CDK4 P11802 human Rb 24708 P33568 Rb1 rat S787 447979 sPYKFSSsPLRIPGG Rb_C X 9301 -CDK4 CDK4 P11802 human FOXM1 2305 Q08050 FOXM1 human S522 8146040 KSySGLRsPtRCVSE X -CDK4 CDK4 P11802 human Rb 5925 P06400 RB1 human T826 447984 LPtPtkMtPRsRILV Rb_C X -CDK4 CDK4 P11802 human Rb 19645 P13405 Rb1 mouse S804 448717 IyIsPLksPyKIsEG Rb_C X 9308; 8974; 4277; 40283; 8957; 8516; 11917; 41359; 75864 -CDK4 CDK4 P11802 human E2A 6929 P15923 TCF3 human S139 455905 LNsPGPLsPsGMKGT X -CDK4 CDK4 P11802 human Rb-like 2 5934 Q08999 RBL2 human S672 448254 tLyDRySsPPAsTtR X -CDK4 CDK4 P11802 human IRS2 384783 P81122 Irs2 mouse S388 1984215 sVAGsPLsPGPVRAP X -CDK4 CDK4 P11802 human FLCN 201163 Q8NFG4 FLCN human S571 31085315 HLMSTVRsPTASESR X X -CDK4 CDK4 P11802 human Rb 5925 P06400 RB1 human S795 447979 sPykFPssPLrIPGG Rb_C X 9301 -CDK4 CDK4 P11802 human ATOH1 11921 P48985 Atoh1 mouse S309 57761909 MMAQKDLsPsLPGGI X -CDK4 CDK4 P11802 human AML2 864 Q13761 RUNX3 human S356 7705800 SSSGGDRsPTRMLAS RunxI X X -CDK4 CDK4 P11802 human CELF1 10658 Q92879 CELF1 human S302 3347301 TSSGSsPsSSSSNSV X -CDK4 CDK4 P11802 human Rb 5925 P06400 RB1 human T252 449821 PINGsPRtPRRGQNR X X -CDK4 CDK4 P11802 human Rb-like 1 5933 P28749 RBL1 human S975 450986 HIKQQPGsPRRIsQQ Rb_C X -CDK4 CDK4 P11802 human Rb-like 1 5933 P28749 RBL1 human T369 451295 KRSFAPstPLtGRRY X -CDK4 CDK4 P11802 human CELF1 13046 P28659 Celf1 mouse S302 3347301 TSSGSSPsSSSSNSV X -CDK4 CDK4 P11802 human GCN5 2648 Q92830 KAT2A human T272 33703200 LNYWKLEtPAQFRQR PCAF_N X X -CDK4 CDK4 P11802 human GATA4 2626 P43694 GATA4 human S105 449604 AYTPPPVsPRFsFPG GATA-N X X -CDK4 CDK4 P11802 human Rb 5925 P06400 RB1 human S788 450022 PIPHIPrsPykFPss Rb_C X -CDK4 CDK4 P11802 human FOXM1 2305 Q08050 FOXM1 human T627 3194576 tPEsWRLtPPAKVGG X X -CDK4 CDK4 P11802 human p21Cip1 1026 P38936 CDKN1A human S98 478193 GGRRPGTsPALLQGT X -CDK4 CDK4 P11802 human Rb 5925 P06400 RB1 human S249 447975 AVIPINGsPRtPRRG X X -CDK4 CDK4 P11802 human SMAD3 4088 P84022 SMAD3 human T179 451177 PQSNIPEtPPPGYLS X -CDK4 CDK4 P11802 human Rb-like 2 5934 Q08999 RBL2 human S1035 449738 NMDAPPLsPyPFVRt X -CDK4 CDK4 P11802 human SMAD3 4088 P84022 SMAD3 human S213 451180 NLsPNPMsPAHNNLD X -CDK4 CDK4 P11802 human Rb 5925 P06400 RB1 human S612 447977 MyLsPVRsPKKKGsT X -CDK4 CDK4 P11802 human FLCN 201163 Q8NFG4 FLCN human S73 3206877 GAsVEsssPGPKKSD X X -CDK4 CDK4 P11802 human FOXM1 2305 Q08050 FOXM1 human S704 449265 IDVPKPGsPEPQVSG X -CDK4 CDK4 P11802 human TFEB 7942 P19484 TFEB human S142 3181628 AGNsAPNsPMAMLHI MITF_TFEB_C_3_N X X -CDK4 CDK4 P11802 human AML3 860 Q13950 RUNX2 human S465 460684 MVPGGDRsPSRMLPP RunxI X -CDK4 CDK4 P11802 human Rb-like 1 5933 P28749 RBL1 human S640 451296 RRDMQPLsPIsVHER X -CDK4 CDK4 P11802 human PELP1 27043 Q8IZL8 PELP1 human S477 470174 ADALKLRsPRGsPDG NUC202 X X -CDK4 CDK4 P11802 human IRS2 384783 P81122 Irs2 mouse S1226 27451056 GCPGGSSsPMRRETS X -CDK4 CDK4 P11802 human p21Cip1 1026 P38936 CDKN1A human S130 455618 sGEQAEGsPGGPGDs X -CDK4 CDK4 P11802 human GATA4 14463 Q08369 Gata4 mouse S160 31834900 GFAGSYSsPYPAYMA GATA-N X -CDK4 CDK4 P11802 human FOXM1 2305 Q08050 FOXM1 human S489 22648002 PPLEEWPsPAPSFkE X X -CDK4 CDK4 P11802 human SMAD3 4088 P84022 SMAD3 human S208 451179 DAGsPNLsPNPMsPA X -CDK4 CDK4 P11802 human BRCA1 672 P38398 BRCA1 human S632 478486 LVVSRNLsPPNCTEL X X -CDK4 CDK4 P11802 human TFEB 7942 P19484 TFEB human S114 3181613 HIsPAQGsPkPPPAA MITF_TFEB_C_3_N X -CDK4 CDK4 P11802 human SMAD3 4088 P84022 SMAD3 human S204 451178 NHSMDAGsPNLsPNP X -CDK4 CDK4 P11802 human FOXM1 2305 Q08050 FOXM1 human S4 22648000 ____MKTsPRRPLIL X -CDK4 CDK4 P11802 human GCN5 2648 Q92830 KAT2A human S372 33703201 EEIYGANsPIWESGF X X -CDK4 CDK4 P11802 human TFE3 7030 P19532 TFE3 human S246 56653430 PTGSAPNsPMALLTI MITF_TFEB_C_3_N X X -CDK4 CDK4 P11802 human FLNA 2316 P21333 FLNA human S2152 451357 tRRRRAPsVANVGsH Filamin X 4761 -CDK4 CDK4 P11802 human Rb 5925 P06400 RB1 human T373 447982 VNVIPPHtPVRTVMN RB_A X -CDK4 CDK4 P11802 human SOD2 6648 P04179 SOD2 human S106 7577901 SIFWTNLsPNGGGEP Sod_Fe_N X X -CDK4 CDK4 P11802 human RPRM 56475 Q9NS64 RPRM human S98 15722493 LVKDRRPsKEVEAVV X X -CDK4 CDK4 P11802 human MDM4 4194 O15151 MDM4 human S314 62381100 TECKKFNsPSKRYCF zf-RanBP X -CDK4 CDK4 P11802 human FOXM1 2305 Q08050 FOXM1 human T600 478080 EVGGPFKtPIkETLP X 14655 -CDK4 CDK4 P11802 human p53 7157 P04637 TP53 human R249 394791401 CMGGMNRrPILTIIT P53 X X -CDK4 CDK4 P11802 human Rb-like 1 5933 P28749 RBL1 human S964 451297 MMDAPPLsPFPHIKQ Rb_C X -CDK4 CDK4 P11802 human VCP 7415 P55072 VCP human T509 4271173 kFLkFGMtPskGVLF X -CDK4 CDK4 P11802 human TOB2 10766 Q14106 TOB2 human S254 14161520 PAPQSQLsPNAKEFV PAM2 X -CDK4 CDK4 P11802 human Rb 5925 P06400 RB1 human S608 447976 tAADMyLsPVRsPKK X 2181; 8147 -CDK4 CDK4 P11802 human Rb 5925 P06400 RB1 human S807 447980 PGGNIyIsPLksPyk Rb_C X X 9308; 8974; 4277; 40283; 8957; 8516; 11917; 99274; 41359; 75864; 72443 -CDK4 CDK4 P11802 human FLNA 2316 P21333 FLNA human S1459 452266 kCsGPGLsPGMVRAN Filamin X -CDK4 CDK4 P11802 human SMAD3 4088 P84022 SMAD3 human T8 452179 MSSILPFtPPIVkRL X -CDK4 CDK4 P11802 human FOXM1 2305 Q08050 FOXM1 human T620 3194573 SkSVLPRtPEsWRLt X X -CDK4 CDK4 P11802 human WDR77 79084 Q9BQA1 WDR77 human S306 17976600 FVRDATWsPLNHSLL X -CDK4 CDK4 P11802 human SPOP 8405 O43791 SPOP human S6 36136244 __MSRVPsPPPPAEM X -CDK4 CDK4 P11802 human RASSF1 iso2 11186 Q9NS23-2 RASSF1 human S203 484000 TsVRRRtsFYLPKDA RA X X -CDK4 CDK4 P11802 human TSC2 7249 P49815 TSC2 human S1217 1868502602 MSLENPLsPFSSDIN X -CDK4 CDK4 P11802 human Rb 5925 P06400 RB1 human S811 448717 IyIsPLksPykIsEG Rb_C X X 9308; 8974; 4277; 40283; 8957; 8516; 11917; 41359; 75864; 63276 -CDK4 CDK4 P11802 human WDR77 79084 Q9BQA1 WDR77 human T5 471217 ___MRkEtPPPLVPP X -CDK4 CDK4 P11802 human FOXM1 2305 Q08050 FOXM1 human S451 7320841 LLFGEGFsPLLPVQT X -CDK4 CDK4 P11802 human MEF2D 4209 Q14814 MEF2D human S110 470517 GEDsLEQsPLLEDKy HJURP_C X -CDK4 CDK4 P11802 human FLCN 201163 Q8NFG4 FLCN human S62 3206874 NSRMRAHsPAEGAsV X X -CDK4 CDK4 P11802 human Rb 19645 P13405 Rb1 mouse S800 447980 PGGNIyIsPLksPyK Rb_C X 9308; 8974; 4277; 40283; 8957; 8516; 11917; 41359; 75864; 72443 -CDK4 CDK4 P11802 human FOXM1 2305 Q08050 FOXM1 human S35 11092388 SEEEPKRsPAQQEsN X 14170 -Csnk1a1 CK1A Q8BK63 mouse NANOG 71950 Q80Z64 Nanog mouse S131 1870790708 QQMQELssILNLSYk Homeodomain X -Csnk1a1 CK1A Q8BK63 mouse CTNNB1 12387 Q02248 Ctnnb1 mouse S45 447488 GATtTAPsLsGkGNP X 9565; 9564; 24710; 70034; 19807; 96727; 77605 -Csnk1a1 CK1A Q8BK63 mouse NANOG 71950 Q80Z64 Nanog mouse S130 1870790707 LQQMQELssILNLSY Homeodomain X -Melk MELK Q61846 mouse SMAD7 4092 O15105 SMAD7 human T96 15613800 EADLKALtHSVLkKL MH1 X X -Melk MELK Q61846 mouse p21Cip1 1026 P38936 CDKN1A human T55 1869957900 RWNFDFVtEtPLEGD CDI X X -Melk MELK Q61846 mouse TXN 7295 P10599 TXN human T76 28716000 CEVKCMPtFQFFkKG Thioredoxin X X -Melk MELK Q61846 mouse PDK1 5170 O15530 PDPK1 human T354 25256100 WENLHQQtPPKLTAY X -Melk MELK Q61846 mouse SMAD2 4087 Q15796 SMAD2 human S245 448794 NQsMDTGsPAELsPT X X 3104 -Melk MELK Q61846 mouse p53 22059 P02340 Tp53 mouse S18 447490 IsLELPLsQEtFsGL P53_TAD X X 9284; 9286; 12571; 56979 -Melk MELK Q61846 mouse ASK1 26408 O35099 Map3k5 mouse T845 448394 GINPCtEtFTGtLQY Pkinase X X 3765 -Melk MELK Q61846 mouse SMAD4 4089 Q13485 SMAD4 human S343 15613801 GETFKVPsSCPIVTV MH2 X X -Melk MELK Q61846 mouse SMAD3 4088 P84022 SMAD3 human S204 451178 NHSMDAGsPNLsPNP X X -Melk MELK Q61846 mouse STRAP 20901 Q9Z1Z2 Strap mouse S188 38410205 NFNMSVSsMEYIPEG X X -MAP3K3 MEKK3 Q99759 human GLI1 2735 P08151 GLI1 human S201 1034327200 PLEGDMSsPNstGIQ X -MAP3K3 MEKK3 Q99759 human GLI1 2735 P08151 GLI1 human S243 27708601 DCRWDGCsQEFDSQE X -MAP3K3 MEKK3 Q99759 human RCAN1 1827 P53805 RCAN1 human S163 456022 PDKQFLIsPPAsPPV Calcipressin X -MAP3K3 MEKK3 Q99759 human RCAN1 1827 P53805 RCAN1 human S167 456023 FLIsPPAsPPVGWKQ Calcipressin X -MAP3K3 MEKK3 Q99759 human GLI1 2735 P08151 GLI1 human T1074 41595601 QRGSsGHtPPPsGPP X 35875 -MAP3K3 MEKK3 Q99759 human GLI1 2735 P08151 GLI1 human S1078 1034327202 sGHtPPPsGPPNMAV X -MAP3K3 MEKK3 Q99759 human ANKRD3 72388 Q9ERK0 Ripk4 mouse T184 2926100 SMDGLFGtIAYLPPE Pkinase X X -MAP3K3 MEKK3 Q99759 human p47phox 17969 Q09014 Ncf1 mouse S208 465580 KRGWVPAsYLEPLDS X -MAP3K3 MEKK3 Q99759 human GLI1 2735 P08151 GLI1 human S968 1034327201 SGSYPTPsPCHENFV X -MAP3K3 MEKK3 Q99759 human GLI1 2735 P08151 GLI1 human S204 34426682 GDMSsPNstGIQDPL X - CDK5 no information HMGB1 25459 P63159 Hmgb1 rat S181 20506700 GVVkAEKsKKKKEEE X - CDK5 no information HMGB1 25459 P63159 Hmgb1 rat K3 459196 _____MGkGDPKKPR X -Plk4 PLK4 Q64702 mouse PLK4 20873 Q64702 Plk4 mouse S285 12654000 TVEDsMDsGHAtLst X -Plk4 PLK4 Q64702 mouse PLK4 20873 Q64702 Plk4 mouse S297 12654005 LsttItAssGtsLsG X -Plk4 PLK4 Q64702 mouse PLK4 20873 Q64702 Plk4 mouse S282 12654003 DVGTVEDsMDsGHAt X -Plk4 PLK4 Q64702 mouse PLK4 20873 Q64702 Plk4 mouse T295 12654001 AtLsttItAssGtsL X -Plk4 PLK4 Q64702 mouse PLK4 20873 Q64702 Plk4 mouse T293 12654011 GHAtLsttItAssGt X -Plk4 PLK4 Q64702 mouse PLK4 20873 Q64702 Plk4 mouse S303 12654008 AssGtsLsGsLLDRR X -Plk4 PLK4 Q64702 mouse PLK4 20873 Q64702 Plk4 mouse S305 12122401 sGtsLsGsLLDRRLL X -Plk4 PLK4 Q64702 mouse PLK4 20873 Q64702 Plk4 mouse S291 12654010 DsGHAtLsttItAss X -Plk4 PLK4 Q64702 mouse PLK4 20873 Q64702 Plk4 mouse T300 12654006 tItAssGtsLsGsLL X -Plk4 PLK4 Q64702 mouse PLK4 20873 Q64702 Plk4 mouse S301 12654009 ItAssGtsLsGsLLD X -Plk4 PLK4 Q64702 mouse PLK4 20873 Q64702 Plk4 mouse S298 12654004 sttItAssGtsLsGs X -Plk4 PLK4 Q64702 mouse PLK4 20873 Q64702 Plk4 mouse T289 12654002 sMDsGHAtLsttItA X -Plk4 PLK4 Q64702 mouse PLK4 20873 Q64702 Plk4 mouse T292 12654007 sGHAtLsttItAssG X -Mapk3 ERK1 Q63844 mouse IRF3 54131 P70671 Irf3 mouse S171 6370303 DPSQQLPsPNVNNFL X -Mapk3 ERK1 Q63844 mouse IRS1 16367 P35569 Irs1 mouse S612 447562 DDGyMPMsPGVAPVP X 3193; 2386; 3203 -Mapk3 ERK1 Q63844 mouse RREB1 68750 Q3UH06 Rreb1 mouse S970 4719142 AGQAEPLsPRPPPCP X -Mapk3 ERK1 Q63844 mouse Jun 16476 P05627 Jun mouse S73 447943 VGLLKLAsPELERLI Jun X 9164; 3270; 8752; 12714; 77955 -Mapk3 ERK1 Q63844 mouse GATA1 14460 P17679 Gata1 mouse S26 451232 VDSALVSsPSDSTGF X X -Mapk3 ERK1 Q63844 mouse FOXO1A 56458 Q9R1E0 Foxo1 mouse S326 448076 stISGRLsPIMtEQD X -Mapk3 ERK1 Q63844 mouse BIM 12125 O54918 Bcl2l11 mouse S55 454235 GDRCPHGsPQGPLAP X 4550 -Mapk3 ERK1 Q63844 mouse GJA1 14609 P23242 Gja1 mouse S282 448854 tAPLsPMsPPGykLV X -Mapk3 ERK1 Q63844 mouse p70S6K 6198 P23443 RPS6KB1 human S447 448357 GsPRtPVsPVkFsPG X 9204 -Mapk3 ERK1 Q63844 mouse ELK1 13712 P41969 Elk1 mouse S390 449757 LsPIAPRsPAKLSFQ X -Mapk3 ERK1 Q63844 mouse MAPKAPK2 17164 P49138 Mapkapk2 mouse T208 448269 TSHNsLttPCYtPYY Pkinase X 3316 -Mapk3 ERK1 Q63844 mouse ELK1 13712 P41969 Elk1 mouse T337 2751400 GGQGPERtPGSGTSS X -Mapk3 ERK1 Q63844 mouse ETV1 14009 P41164 Etv1 mouse S146 3059603 tPSStPVsPLHHASP ETS_PEA3_N X -Mapk3 ERK1 Q63844 mouse SYN3 8224 O14994 SYN3 human S470 455901 PQGQQPLsPQsGsPQ X -Mapk3 ERK1 Q63844 mouse GATA6 14465 Q61169 Gata6 mouse S264 2833503 ASARFPYsPSPPMAN GATA-N X -Mapk3 ERK1 Q63844 mouse ELK1 13712 P41969 Elk1 mouse S325 471887 RDLELPLsPSLLGGQ X -Mapk3 ERK1 Q63844 mouse AEBP1 11568 Q640N1 Aebp1 mouse T1003 455321 VDPSRPMtPQQRRMQ X -Mapk3 ERK1 Q63844 mouse ER-beta 13983 O08537 Esr2 mouse S87 447915 WPTSGHLsPLATHCQ ERbeta_N X -Mapk3 ERK1 Q63844 mouse STAR 20845 P51557 Star mouse S232 2089100 VLHPLAGsPSKTKLT START X X -Mapk3 ERK1 Q63844 mouse PXN 19303 Q8VI36 Pxn mouse S83 451113 yAHQQPPsPLPVyss Paxillin X -Mapk3 ERK1 Q63844 mouse ELK1 13712 P41969 Elk1 mouse S423 469193 LStPVVLsPGPQKP_ X -Mapk3 ERK1 Q63844 mouse RREB1 68750 Q3UH06 Rreb1 mouse S161 4719122 TTAAAPPsPLKRRRL X -Mapk3 ERK1 Q63844 mouse calponin 3 71994 Q9DAW9 Cnn3 mouse S293 4776192 QGtGTNGsEIsDsDy X -Mapk3 ERK1 Q63844 mouse ETV1 14009 P41164 Etv1 mouse T139 3059605 MRPSNPPtPSStPVs ETS_PEA3_N X -Mapk3 ERK1 Q63844 mouse ETV1 14009 P41164 Etv1 mouse T143 3059604 NPPtPSStPVsPLHH ETS_PEA3_N X -Mapk3 ERK1 Q63844 mouse STXBP1 20910 O08599 Stxbp1 mouse S241 36440508 DRGFDPSsPVLHELT Sec1 X X -Mapk3 ERK1 Q63844 mouse MAPKAPK2 17164 P49138 Mapkapk2 mouse T320 448273 QsTKVPQtPLHtsRV X 3007; 3041 -Mapk3 ERK1 Q63844 mouse GJA1 14609 P23242 Gja1 mouse S279 448853 SsPtAPLsPMsPPGy X -Mapk3 ERK1 Q63844 mouse PR 18667 Q00175 Pgr mouse S294 447987 SPIAPGRsPLATTVV Prog_receptor X 13736 -Mapk3 ERK1 Q63844 mouse MBP 618684 P02687 MBP cow T97 450929 KNIVtPRtPPPSQGK Myelin_MBP X -Mapk3 ERK1 Q63844 mouse TAL1 21349 P22091 Tal1 mouse S122 450663 DGRMVQLsPPALAAP X -Mapk3 ERK1 Q63844 mouse ETV1 14009 P41164 Etv1 mouse S94 3059606 KIKKEPHsPCSELGS ETS_PEA3_N X -Mapk3 ERK1 Q63844 mouse ER-beta 13983 O08537 Esr2 mouse S105 447914 LYAEPQKsPWCEARS ERbeta_N X -Mapk3 ERK1 Q63844 mouse ELK1 13712 P41969 Elk1 mouse S384 447872 IHFWSTLsPIAPRsP X X 9181; 9186 -Mapk3 ERK1 Q63844 mouse PPP1R1A 58200 Q9ERT9 Ppp1r1a mouse S67 447758 LKSTLsMsPRQRKKM DARPP-32 X -Mapk3 ERK1 Q63844 mouse Kv4.2 16508 Q9Z0V2 Kcnd2 mouse S616 457613 EGDDRPEsPEYsGGN X -Mapk3 ERK1 Q63844 mouse FOXO3A 56484 Q9WVH4 Foxo3 mouse S293 472326 QLSkWPGsPTSRssD X 5538 -Mapk3 ERK1 Q63844 mouse MEK1 26395 P31938 Map2k1 mouse T292 448287 EtPPRPRtPGRPLsS Pkinase X X 26975 -Mapk3 ERK1 Q63844 mouse KSR 16706 Q61097 Ksr1 mouse S443 449300 TTSSTPSsPAPFLTS X -Mapk3 ERK1 Q63844 mouse BIM 12125 O54918 Bcl2l11 mouse S65 449330 GPLAPPAsPGPFATR X 4581; 4585 -Mapk3 ERK1 Q63844 mouse p53 22059 P02340 Tp53 mouse S18 447490 IsLELPLsQEtFsGL P53_TAD X X 9284; 9286; 12571; 56979 -Mapk3 ERK1 Q63844 mouse PKCA 18750 P20444 Prkca mouse T638 448685 TRGQPVLtPPDQLVI Pkinase_C X X 9375 -Mapk3 ERK1 Q63844 mouse SRm300 75956 Q8BTI8 Srrm2 mouse S1068 453278 GsLsRsssPVtELtA X -Mapk3 ERK1 Q63844 mouse KLF4 16600 Q60793 Klf4 mouse S132 24976100 ASASSSSsPASSGPA X -Mapk3 ERK1 Q63844 mouse p90RSK 20111 P18653 Rps6ka1 mouse S369 447990 HQLFRGFsFVATGLM Pkinase_C X 9341; 9335; 13575; 11989; 12032; 75266; 93317; 13397; 13588 -Mapk3 ERK1 Q63844 mouse mGluR5 108071 Q3UVX5 Grm5 mouse S1158 25581600 LVALtPPsPFRDSVD GluR_Homer-bdg X -Mapk3 ERK1 Q63844 mouse Cofilin-1 12631 P18760 Cfl1 mouse T25 7990494 MkVRKSstPEEVKkR Cofilin_ADF X -Mapk3 ERK1 Q63844 mouse RANBP3 71810 Q9CT10 Ranbp3 mouse S58 460735 VKRERtssLtHsEEK X -Mapk3 ERK1 Q63844 mouse PXN 19303 Q8VI36 Pxn mouse S130 450228 KQksAEPsPtVMsss Paxillin X -Mapk3 ERK1 Q63844 mouse H3 iso3 15081 P84244 H3f3b mouse S28 455677 ATkAArksAPSTGGV Histone X 9713 -Mapk3 ERK1 Q63844 mouse Fos 314322 P12841 Fos rat T325 448483 TELEPLCtPVVTCtP X -Mapk3 ERK1 Q63844 mouse JunB 16477 P09450 Junb mouse S256 452631 RDAtPPVsPINMEDQ X -Mapk3 ERK1 Q63844 mouse Jun 16476 P05627 Jun mouse S63 447686 kNsDLLtsPDVGLLK Jun X 5464; 9261; 2361; 97721; 91952 -Mapk3 ERK1 Q63844 mouse EGR1 13653 P08046 Egr1 mouse S26 458492 PFGSFPHsPTMDNYP X -Mapk3 ERK1 Q63844 mouse STXBP1 20910 O08599 Stxbp1 mouse T574 454395 IGSTHILtPQKLLDt Sec1 X -Mapk3 ERK1 Q63844 mouse TACE 11491 Q9Z0F8 Adam17 mouse T735 449804 kPFPAPQtPGRLQAL X -Mapk3 ERK1 Q63844 mouse NFAT3 73181 Q8K120 Nfatc4 mouse S676 455348 SNGRRKRsPTQSFKF RHD_dimer X -Mapk3 ERK1 Q63844 mouse Bcl-2 12043 P10417 Bcl2 mouse S70 448395 RDMAARtsPLRPLVA X -Mapk3 ERK1 Q63844 mouse FAK 14083 P34152 Ptk2 mouse S910 447964 KLQPQEIsPPPTANL X -Mapk3 ERK1 Q63844 mouse STF-1 26423 P33242 Nr5a1 mouse S203 447603 EYPEPYAsPPQQPGP X -Mapk3 ERK1 Q63844 mouse ATF-2 11909 P16951 Atf2 mouse T53 448225 IVADQtPtPtRFLKN X X 9225; 9221; 5112; 94125; 13850; 40749; 15411; 24329; 61584; 27934; 92109; 20534; 35858 -Mapk3 ERK1 Q63844 mouse SHC1 20416 P98083 Shc1 mouse S36 448508 TPPEELPsPSASSLG X -Mapk3 ERK1 Q63844 mouse p70S6K 6198 P23443 RPS6KB1 human T444 448358 RFIGsPRtPVsPVkF X 9204 -Mapk3 ERK1 Q63844 mouse p70S6K 6198 P23443 RPS6KB1 human S434 448356 sFEPKIRsPRRFIGs X -Mapk3 ERK1 Q63844 mouse STMN1 16765 P54227 Stmn1 mouse S25 448555 QAFELILsPRskEsV Stathmin X -Mapk3 ERK1 Q63844 mouse C/EBP-beta 12608 P28033 Cebpb mouse T188 447878 sSssPPGtPSPADAK X X 3084 -Mapk3 ERK1 Q63844 mouse NOXA1 241275 Q8CJ00 Noxa1 mouse Y252 1869151102 GHTSPGLyDSLLASR X -Mapk3 ERK1 Q63844 mouse BIM 12125 O54918 Bcl2l11 mouse S100 449602 FSFDTDRsPAPMsCD X -Mapk3 ERK1 Q63844 mouse RCAN1 54720 Q9JHG6 Rcan1 mouse S165 456023 FLIsPPAsPPVGWKQ Calcipressin X -Mapk3 ERK1 Q63844 mouse PCYT1A 140544 P19836 Pcyt1a rat S315 451321 GRMLQAIsPKQsPss X -Mapk3 ERK1 Q63844 mouse NDEL1 83431 Q9ERR1 Ndel1 mouse T219 468252 ASLsLPAtPVGKGTE NUDE_C X -Mapk3 ERK1 Q63844 mouse ELK1 2002 P19419 ELK1 human S383 447872 IHFWSTLsPIAPRsP X 9181; 9186 -Mapk3 ERK1 Q63844 mouse MEK1 26395 P31938 Map2k1 mouse T386 448288 IGLNQPstPtHAASI X -Mapk3 ERK1 Q63844 mouse TH 25085 P04177 Th rat S31 448544 KQAEAVtsPRFIGRR TOH_N X 3370; 13041 -Mapk3 ERK1 Q63844 mouse PLA2G4A 18783 P47713 Pla2g4a mouse S505 447597 LNTSYPLsPLRDFss PLA2_B X 2831; 53044 -Mapk3 ERK1 Q63844 mouse MEK1 100009316 P29678 MAP2K1 rabbit T292 448287 ETPPRPRtPGRPLsS Pkinase X -Mapk3 ERK1 Q63844 mouse RSK2 110651 P18654 Rps6ka3 mouse S386 448065 HQLFRGFsFVAITSD Pkinase_C X 9341; 9335; 13575; 11989; 12032; 75266; 93317; 13397; 13588 -Mapk3 ERK1 Q63844 mouse Ets-2 23872 P15037 Ets2 mouse T72 447688 SCELPLLtPCSKAVM X -Mapk3 ERK1 Q63844 mouse Akt1 11651 P31750 Akt1 mouse T308 447856 KDGAtMKtFCGtPEy Pkinase X 5106; 2965; 9275; 4056; 5056; 13842; 13038; 43506; 48646; 86758; 80722; 77440; 80556 -Mapk3 ERK1 Q63844 mouse BIM 12125 O54918 Bcl2l11 mouse T112 449071 sCDKStQtPsPPCQA X -Mapk3 ERK1 Q63844 mouse STAT1 20846 P42225 Stat1 mouse S727 447753 tDNLLPMsPEEFDEM STAT1_TAZ2bind X 9177; 8826; 62390 -Mapk3 ERK1 Q63844 mouse TH 21823 P24529 Th mouse S31 448544 KQAEAVtsPRFIGRR TOH_N X 3370; 13041 -TGFBR1 TGFBR1 P36897 human p63 iso2 8626 Q9H3D4-2 TP63 human S68 451601 TFDALsPsPAIPSNT X X -TGFBR1 TGFBR1 P36897 human SMAD2 4087 Q15796 SMAD2 human S467 447495 sVRCssMs_______ X X 3108; 8828; 11979; 26945; 55041; 68550; 18338; 56532; 67804 -TGFBR1 TGFBR1 P36897 human ENG 2022 P17813 ENG human S646 12064201 StNHSIGsTQstPCS X -TGFBR1 TGFBR1 P36897 human p63 iso2 8626 Q9H3D4-2 TP63 human S66 451600 SSTFDALsPsPAIPS X X -TGFBR1 TGFBR1 P36897 human OTUB1 55611 Q96FW1 OTUB1 human S18 3072783 QEPLGsDsEGVNCLA X -TGFBR1 TGFBR1 P36897 human TGFBR3 7049 Q03167 TGFBR3 human S831 23940713 SPPASENsSAAHSIG X X -TGFBR1 TGFBR1 P36897 human SMAD2 4087 Q15796 SMAD2 human S465 447494 sPsVRCssMs_____ X X 3108; 8828; 11979; 26945; 55041; 68550; 18338; 56532; 67804 -TGFBR1 TGFBR1 P36897 human EEF1A1 1915 P68104 EEF1A1 human S300 15629200 EMHHEALsEALPGDN GTP_EFTU_D2 X X -TGFBR1 TGFBR1 P36897 human ENG 2022 P17813 ENG human S649 12064200 HSIGsTQstPCStSS X -TGFBR1 TGFBR1 P36897 human SMAD2 4087 Q15796 SMAD2 human S464 447567 GsPsVRCssMs____ X X -Rps6ka6 RSK4 NP_001178650 rat BSN 12217 O88737 Bsn mouse S2860 456576 KTLQRsLsDPKPLsP X -Rps6ka6 RSK4 NP_001178650 rat BSN 29138 O88778 Bsn rat S2845 456576 KTLQRSLsDPKPLSP X -AURKB AurB Q9N0X0 pig H3 8350 P68431 H3C1 human S10 455676 tkQtArkstGGkAPr Histone X 9701; 9711; 9606; 3465; 3642; 3377; 3475; 3458; 5764; 47398; 8481; 8552; 53348; 29237; 66065; 43185; 64522; 52725 -AURKB AurB Q9N0X0 pig AurB 396955 Q9N0X0 AURKB pig T232 450325 APSLRRKtMCGTLDY Pkinase X -MAP3K21 MLK4 Q5TCX8 human IL17RB 55540 Q9NRM6 IL17RB human Y447 5756439 LHKYVVVyFREIDTK SEFIR X -Stk38 NDR1 Q91VJ4 mouse PIK4CB iso2 5298 Q9UBF8-2 PI4KB human S277 457620 RTHQRSKsDATASIS X -Stk38 NDR1 Q91VJ4 mouse PANX2 406218 Q6IMP4 Panx2 mouse S514 25123901 KKHTRHFsLDVHPYI X -Stk38 NDR1 Q91VJ4 mouse YAP1 22601 P46938 Yap1 mouse S382 3190672 TyHSRDEstDsGLSM X 13619 -Stk38 NDR1 Q91VJ4 mouse RAB3IP 216363 Q68EF0 Rab3ip mouse S240 4734219 RGHTRNKsTSsAMGG Sec2p X -Stk38 NDR1 Q91VJ4 mouse RAB11FIP5 52055 Q8R361 Rab11fip5 mouse S307 456449 LTHKRtysDEAsQLR X -Stk38 NDR1 Q91VJ4 mouse AAK1 269774 Q3UHJ0 Aak1 mouse S635 467380 AGHRRILsDVtHsAV X 92438 -Stk38 NDR1 Q91VJ4 mouse NDR1 106504 Q91VJ4 Stk38 mouse S281 448828 NRRQLAFsTVGTPDy Pkinase X -Stk38 NDR1 Q91VJ4 mouse YAP1 22601 P46938 Yap1 mouse S112 448847 PQHVRAHssPAsLQL X 4911; 13008; 92367; 57706 -Sik1 SIK Q60670 mouse TORC3 70461 Q91X84 Crtc3 mouse S162 7101661 SALNRTNsDSALHTS TORC_M X -Sik1 SIK Q60670 mouse TORC3 70461 Q91X84 Crtc3 mouse S370 1210886 SLRLFsLsNPsLSTT X -Sik1 SIK Q60670 mouse SCARB1 25073 P97943 Scarb1 rat S496 14567809 AYSESLMsPAAkGTV X -Sik1 SIK Q60670 mouse PDE4D 238871 Q01063 Pde4d mouse S141 483645 SDsDyDLsPKSMSRN X X -Sik1 SIK Q60670 mouse TORC3 70461 Q91X84 Crtc3 mouse S62 3203139 LtQyHGGsLPNVSQL TORC_N X -Sik1 SIK Q60670 mouse TORC3 70461 Q91X84 Crtc3 mouse S329 468980 SGLQSsRsNPsIQAT X -Sik1 SIK Q60670 mouse PDE4D 238871 Q01063 Pde4d mouse S136 483644 sFLYRSDsDyDLsPK X X -Grk2 GRK2 Q99MK8 mouse IRS1 16367 P35569 Irs1 mouse S612 447562 DDGyMPMsPGVAPVP X 3193; 2386; 3203 -Grk2 GRK2 Q99MK8 mouse SMO 319757 P56726 Smo mouse T597 1872776116 ELSFsMHtVsHDGPV X -Grk2 GRK2 Q99MK8 mouse SMO 319757 P56726 Smo mouse S642 1872776120 AILPQDVsVtPVAtP X -Grk2 GRK2 Q99MK8 mouse KOR-1 18387 P33534 Oprk1 mouse T357 52467201 MRMERQstNRVRNtV X -Grk2 GRK2 Q99MK8 mouse SMO 319757 P56726 Smo mouse S599 1872776118 SFsMHtVsHDGPVAG X -Grk2 GRK2 Q99MK8 mouse MOR-1 18390 P42866 Oprm1 mouse T376 20727901 NtREHPstANtVDRT X -Grk2 GRK2 Q99MK8 mouse IRS1 16367 P35569 Irs1 mouse S635 447507 yMPMsPKsVsAPQQI X 2388 -Grk2 GRK2 Q99MK8 mouse KOR-1 18387 P33534 Oprk1 mouse S356 52467200 KMRMERQstNRVRNt X -Grk2 GRK2 Q99MK8 mouse ADRB2 11555 P18762 Adrb2 mouse S355 458916 KTYGNGYssNSNGRT X -Grk2 GRK2 Q99MK8 mouse ADRB2 11555 P18762 Adrb2 mouse S356 458917 TYGNGYssNSNGRTD X -Grk2 GRK2 Q99MK8 mouse PDE6G 18588 P09174 Pde6g mouse T62 449335 PGMEGLGtDITVICP PDE6_gamma X -Grk2 GRK2 Q99MK8 mouse PER2 18627 O54943 Per2 mouse S545 470015 sVAEMQssPPAQVKA X -Grk2 GRK2 Q99MK8 mouse SMO 319757 P56726 Smo mouse S560 1872776110 WCRLTGHsDDEPKRI X -Grk2 GRK2 Q99MK8 mouse SMO 319757 P56726 Smo mouse S594 1872776114 PGQELSFsMHtVsHD X -Grk2 GRK2 Q99MK8 mouse SMO 319757 P56726 Smo mouse T644 1872776122 LPQDVsVtPVAtPVP X -Grk2 GRK2 Q99MK8 mouse MOR-1 18390 P42866 Oprm1 mouse T370 447785 sARIRQNtREHPstA X -Grk2 GRK2 Q99MK8 mouse MOR-1 18390 P42866 Oprm1 mouse S375 447784 QNtREHPstANtVDR X 3451 -Grk2 GRK2 Q99MK8 mouse SMO 319757 P56726 Smo mouse T648 1872776124 VsVtPVAtPVPPEEQ X -Grk2 GRK2 Q99MK8 mouse MOR-1 18390 P42866 Oprm1 mouse T379 20727900 EHPstANtVDRTNHQ X -Notch2 Notch 2 O35516 mouse Akt1 11651 P31750 Akt1 mouse S473 447855 RPHFPQFsysAsGtA Pkinase_C X 9271; 3787; 4060; 4051; 5102; 4058; 2336; 2337; 4075; 4070; 5012; 4071; 92982; 5315; 9563; 9018; 12694; 52240; 11962; 15116; 88106; 26580; 68035; 31957; 23430; 20235 -Notch2 Notch 2 O35516 mouse Akt1 11651 P31750 Akt1 mouse T308 447856 KDGAtMKtFCGtPEy Pkinase X 5106; 2965; 9275; 4056; 5056; 13842; 13038; 43506; 48646; 86758; 80722; 77440; 80556 -Gsk3a GSK3A P18265 rat PPAR-alpha 5465 Q07869 PPARA human S280 1867858200 FHCCQCTsVETVTEL Hormone_recep X -Gsk3a GSK3A P18265 rat PPP1R2 100009520 P11845 PPP1R2 rabbit T73 449051 MKIDEPStPYHSMIG IPP-2 X -Gsk3a GSK3A P18265 rat MAP2 iso2 25595 P15146-2 Map2 rat S136 448323 ETVNLPPsPPPSPAS X 4541 -Gsk3a GSK3A P18265 rat ACLY 24159 P16638 Acly rat T446 455371 NASGSTStPAPsRtA X -Gsk3a GSK3A P18265 rat eIF2B-epsilon 192234 Q64350 Eif2b5 rat S535 449905 VDPEELDsRAGsPQL X -Gsk3a GSK3A P18265 rat CREB iso1 81646 P15337-1 Creb1 rat S133 448228 EILsRRPsYRkILND pKID X 9187; 9196; 9198; 4095; 14228; 14001; 39561; 80120; 44864; 54960; 95995 -Gsk3a GSK3A P18265 rat MAP2 25595 P15146 Map2 rat S136 448323 ETVNLPPsPPPsPAS X 4541 -Gsk3a GSK3A P18265 rat PXN 360820 Q66H76 Pxn rat S126 450227 SFPNKQKsAEPsPtV Paxillin X -Gsk3a GSK3A P18265 rat CRMP-4 25418 Q62952 Dpysl3 rat T509 454328 PVFDLTTtPKGGtPA X -Gsk3a GSK3A P18265 rat CRMP-2 25416 P47942 Dpysl2 rat T514 454386 SVtPKTVtPASsAKT X 9397 -Gsk3a GSK3A P18265 rat CREB iso1 81646 P15337-1 Creb1 rat S129 450092 QKRREILsRRPsYRk pKID X -Gsk3a GSK3A P18265 rat MAP2 iso3 25595 P15146-3 Map2 rat S136 448323 ETVNLPPsPPPSPAS X 4541 -Gsk3a GSK3A P18265 rat MAP2 25595 P15146 Map2 rat T1622 450181 YSSRtPGtPGtPSyP X 4544 -Gsk3a GSK3A P18265 rat ACLY 24159 P16638 Acly rat S450 455372 STStPAPsRtAsFSE X -Gsk3a GSK3A P18265 rat MAP2 25595 P15146 Map2 rat T1625 450182 RtPGtPGtPSyPRTP X 4544 -Gsk3a GSK3A P18265 rat CRMP-2 25416 P47942 Dpysl2 rat T509 448083 PVCEVSVtPKTVtPA X -MAPKAPK5 MAPKAPK5 Q8IW41 human SEPT8 23176 Q92599 SEPTIN8 human S192 25538006 IAKADTIskSELHkF Septin X -MAPKAPK5 MAPKAPK5 Q8IW41 human p53 7157 P04637 TP53 human S37 447532 NVLsPLPsQAMDDLM TAD2 X X 9289 -MAPKAPK5 MAPKAPK5 Q8IW41 human NRF2 4780 Q16236 NFE2L2 human S558 10292703 HLLkkQLstLyLEVF bZIP_Maf X -MAPKAPK5 MAPKAPK5 Q8IW41 human RHEB 6009 Q15382 RHEB human S130 18157800 LHMERVIsYEEGkAL Ras X -MAPKAPK5 MAPKAPK5 Q8IW41 human TH iso3 7054 P07101-3 TH human S19 448542 KGFRRAVsELDAKQA TOH_N X -MAPKAPK5 MAPKAPK5 Q8IW41 human TH iso3 7054 P07101-3 TH human S404 10348000 GELLHCLsEEPEIRA Biopterin_H X -MAPKAPK5 MAPKAPK5 Q8IW41 human TH 7054 P07101 TH human S19 448542 KGFRRAVsELDAKQA TOH_N X -MAPKAPK5 MAPKAPK5 Q8IW41 human kalirin 8997 O60229 KALRN human S487 472573 DVLQRPLsPGNSESL X -MAPKAPK5 MAPKAPK5 Q8IW41 human HSP40 3337 P25685 DNAJB1 human S171 30306602 VTHDLRVsLEEIysG DnaJ_C X X -MAPKAPK5 MAPKAPK5 Q8IW41 human SEPT8 23176 Q92599 SEPTIN8 human S163 25538007 FITPTGHsLKSLDLV Septin X -MAPKAPK5 MAPKAPK5 Q8IW41 human HSP40 3337 P25685 DNAJB1 human S151 23099871 VNFGRsRsAQEPARK X X -MAPKAPK5 MAPKAPK5 Q8IW41 human HSP40 3337 P25685 DNAJB1 human S149 30306601 TNVNFGRsRsAQEPA X X -MAPKAPK5 MAPKAPK5 Q8IW41 human TH iso3 7054 P07101-3 TH human S40 448545 RFIGRRQsLIEDARK TOH_N X 2791 -DAPK2 DAPK2 Q9UIK4 human DAPK2 23604 Q9UIK4 DAPK2 human S318 450028 VRRRWKLsFsIVSLC X -DAPK2 DAPK2 Q9UIK4 human Raptor 57521 Q8N122 RPTOR human S721 4206802 tPrLrsVssyGNIRA X X -DAPK2 DAPK2 Q9UIK4 human Tau iso8 4137 P10636-8 MAPT human S214 447929 GsRsRtPsLPtPPtR X 77348 -Map3k5 ASK1 O35099 mouse CLOCK 12753 O08785 Clock mouse S845 23094535 LPRHRtDsLTDPSKV X -Map3k5 ASK1 O35099 mouse P2Y12 70839 Q9CPV9 P2ry12 mouse T345 138970300 GGEPsEEtPM_____ X -Map3k5 ASK1 O35099 mouse CLOCK 12753 O08785 Clock mouse T843 941453100 QQLPRHRtDsLTDPS X -Map3k5 ASK1 O35099 mouse ASK1 26408 O35099 Map3k5 mouse T845 448394 GINPCtEtFTGtLQY Pkinase X X 3765 -Mapk14 P38A P70618 rat Kv2.1 25736 P15387 Kcnb1 rat S804 473562 ESsPLPTsPKFLRPN X -Mapk14 P38A P70618 rat Bcl-2 24224 P49950 Bcl2 rat S70 448395 RDTAARTsPLRPLVA X -Mapk14 P38A P70618 rat BIM 64547 O88498 Bcl2l11 rat S65 449330 GPLAPPAsPGPFATR X 4581; 4585 -PRKCH PKCH P24723 human ITGB2 3689 P05107 ITGB2 human S745 448532 FEkEKLksQWNNDNP Integrin_b_cyt X -PRKCH PKCH P24723 human SHP-2 5781 Q06124 PTPN11 human S591 469623 GLMQQQksFR_____ X -PRKCH PKCH P24723 human ITGB2 3689 P05107 ITGB2 human T758 448533 NPLFksAtttVMNPk Integrin_b_cyt X -PRKCH PKCH P24723 human SHP-2 5781 Q06124 PTPN11 human S576 469622 CAEMREDsARVyENV X -PRKCH PKCH P24723 human GSK3A 606496 Q2NL51 Gsk3a mouse S21 448584 sGRARtssFAEPGGG X 9337; 9316; 9331; 9327; 8452; 8566 -PRKCH PKCH P24723 human GSK3B 56637 Q9WV60 Gsk3b mouse S9 449111 SGRPRttsFAEsCKP X 9336; 9331; 9327; 9323; 9322; 9325; 5558; 8566; 79774; 8466; 25462; 14026; 14332; 14310; 14630 -PRKCH PKCH P24723 human PKCH 5583 P24723 PRKCH human S32 3074800 tRWsLRHsLFKkGHQ C2 X -PRKCH PKCH P24723 human mGluR5 24418 P31424 Grm5 rat S839 455778 VRSAFTTstVVRMHV X -PRKCH PKCH P24723 human PRKD2 25865 Q9BZL6 PRKD2 human S706 449864 ARIIGEksFRRsVVG Pkinase X -PRKCH PKCH P24723 human PRKD2 25865 Q9BZL6 PRKD2 human S710 449865 GEksFRRsVVGtPAy Pkinase X -PRKCH PKCH P24723 human GSK3A 2931 P49840 GSK3A human S21 448584 sGrARtssFAEPGGG X X 9337; 9316; 9331; 5090; 9327; 8452; 8566 -PRKCH PKCH P24723 human GSK3B 2932 P49841 GSK3B human S9 449111 SGRPRttsFAEsCkP X X 9336; 9331; 9327; 9323; 9322; 9325; 5558; 8566; 79774; 8466; 25462; 14026; 14332; 14310; 14630 -PRKCH PKCH P24723 human PKCH 5583 P24723 PRKCH human S28 3074801 GLQPtRWsLRHsLFK C2 X -PRKCH PKCH P24723 human PRKD1 5587 Q15139 PRKD1 human S738 448589 ARIIGEksFRRsVVG Pkinase X X 2054 -PRKCH PKCH P24723 human AID 11628 Q9WVE0 Aicda mouse T140 6835300 GVQIGIMtFKDYFYC APOBEC2 X -PRKCH PKCH P24723 human PRKD2 25865 Q9BZL6 PRKD2 human S876 448800 QGLAERIsVL_____ X -PRKCH PKCH P24723 human GSTP1 2950 P09211 GSTP1 human S185 455118 SAYVGRLsARPkLkA GST_C_3 X -PRKCH PKCH P24723 human PRKD1 5587 Q15139 PRKD1 human S742 448590 GEksFRRsVVGtPAy Pkinase X X -PRKCH PKCH P24723 human GSTP1 2950 P09211 GSTP1 human S43 455117 VETWQEGsLkAsCLy GST_N X -PLK1 PLK1 P53350 human dynactin 1 1639 Q14203 DCTN1 human S179 15512801 sASAGELsSSEPSTP X X -PLK1 PLK1 P53350 human CCNT1 904 O60563 CCNT1 human S564 28735106 KTYSLSSsFSSSSsT X -PLK1 PLK1 P53350 human Nlp 22981 Q9Y2I6 NINL human S88 451061 RPSDEDssSLESAAS X -PLK1 PLK1 P53350 human PTEN 5728 P60484 PTEN human S380 448313 EPDHyRYsDttDsDP X X 9551; 9554; 9549; 7960 -PLK1 PLK1 P53350 human PINX1 54984 Q96BK5 PINX1 human S226 14823405 ATGKDVEsyLQPkAK X X -PLK1 PLK1 P53350 human CLASP2 23122 O75122 CLASP2 human S1092 27434506 MKLtQEEsFSVWDEH X X -PLK1 PLK1 P53350 human APC1 64682 Q9H1A4 ANAPC1 human T520 455828 GLPAPsLtMsNtMPR X -PLK1 PLK1 P53350 human SynGAP iso3 192117 Q9QUH6-3 Syngap1 rat S777 18710208 EPEQKMLsVNKsVsM DUF3498 X -PLK1 PLK1 P53350 human MAP9 79884 Q49MG5 MAP9 human S289 15105800 SDENKENsFsADHVT X X -PLK1 PLK1 P53350 human PCNT 5116 O95613 PCNT human T1221 25617503 ALPELDRtLSECAEM X -PLK1 PLK1 P53350 human CDC25C 995 P30307 CDC25C human S75 125104500 PkRCLDLsNLSSGEI X -PLK1 PLK1 P53350 human PRC1 9055 O43663 PRC1 human T616 7444691 TSGILNstNIQs___ X -PLK1 PLK1 P53350 human KIF2C 11004 Q99661 KIF2C human S715 3545002 MQLEEQAsRQIsSKK X -PLK1 PLK1 P53350 human MLL5 55904 Q8IZD2 KMT2E human S861 54363512 sPLLLNDsCSLPDLT X -PLK1 PLK1 P53350 human MAD1L1 8379 Q9Y6D9 MAD1L1 human T680 5024706 SKMQLLEtEFSHTVG MAD X -PLK1 PLK1 P53350 human MDC1 9656 Q14676 MDC1 human S20 63083900 EEEEtEQssESLRCN X -PLK1 PLK1 P53350 human VCP 7415 P55072 VCP human T76 1876872800 CIVLsDDtCSDEkIR CDC48_N X X -PLK1 PLK1 P53350 human CDC27 996 P30260 CDC27 human T209 455849 LtEtPQDtIELNRLN X -PLK1 PLK1 P53350 human BORA 79866 Q6PGQ7 BORA human S497 2512942 SSNIQMDsGYNtQNC X -PLK1 PLK1 P53350 human SGO1 72415 Q9CXH7 Sgo1 mouse T146 2535905 QQIAVEEtDCPYQTT X -PLK1 PLK1 P53350 human TNKS 8658 O95271 TNKS human T982 471334 SLIsPAStPSCLsAA X X -PLK1 PLK1 P53350 human CASC5 iso2 57082 Q8NG31-2 KNL1 human T875 40560200 DKNDMDItKSYTIEI MELT X X -PLK1 PLK1 P53350 human TTK 7272 P33981 TTK human T46 41389704 NKISADttDNsGTVN X -PLK1 PLK1 P53350 human CENPQ 55166 Q7L2Z9 CENPQ human T123 40245503 RLLQQCEtLKVPPKk CENP-Q X X -PLK1 PLK1 P53350 human PCNT 5116 O95613 PCNT human T1209 25617502 TAPALEEtWSDVALP X -PLK1 PLK1 P53350 human NDR1 11329 Q15208 STK38 human T407 41425401 EIKSIDDtSNFDEFP Pkinase_C X X -PLK1 PLK1 P53350 human SAPS2 9701 O75170 PPP6R2 human T10 1109469503 WKFDLNTtSHVDkLL X -PLK1 PLK1 P53350 human NDR1 11329 Q15208 STK38 human T7 22553317 _MAMtGstPCssMsN X X -PLK1 PLK1 P53350 human ROCK2 282041 Q28021 ROCK2 cow S1133 1732200 LHIGLDSsSIGSGPG X -PLK1 PLK1 P53350 human CDC20 991 Q12834 CDC20 human S170 23092094 KtCRYIPsLPDrILD X X -PLK1 PLK1 P53350 human TOP2A 7153 P11388 TOP2A human T1343 448763 FsDFDEKtDDEDFVP X -PLK1 PLK1 P53350 human TTK 7272 P33981 TTK human T33 2846502 kFkNEDLtDELsLNK X -PLK1 PLK1 P53350 human NEDD1 121441 Q8NHV4 NEDD1 human S637 9379000 HSLLERysVNEGLVA X -PLK1 PLK1 P53350 human TOP2A 7153 P11388 TOP2A human S1525 448764 PIKyLEEsDEDDLF_ X X -PLK1 PLK1 P53350 human CDC16 8881 Q13042 CDC16 human S112 455864 EkYLkDEsGFkDPSS X -PLK1 PLK1 P53350 human KIF2B 84643 Q8N4N8 KIF2B human T125 25247520 MIPQKNQtAsGDsLD X X -PLK1 PLK1 P53350 human HSP70 3303 P0DMV8 HSPA1B human S633 18010650 GPkGGsGsGPtIEEV X -PLK1 PLK1 P53350 human DVL2 1856 O14641 DVL2 human T206 17301000 MTSELEStSLGDsDE Dishevelled X X -PLK1 PLK1 P53350 human CLASP2 23122 O75122 CLASP2 human S1053 14159685 DQFPDDLsLDHsDLV X X -PLK1 PLK1 P53350 human PTP1B 5770 P18031 PTPN1 human S393 9765677 sPAKGEPsLPEKDED X -PLK1 PLK1 P53350 human MDM2 4193 Q00987 MDM2 human S260 454923 sLDsEDYsLsEEGQE X X -PLK1 PLK1 P53350 human hnRNP U 3192 Q00839 HNRNPU human S59 468001 AMEPGNGsLDLGGDs X X -PLK1 PLK1 P53350 human TOPORS 10210 Q9NS56 TOPORS human S718 5938002 kDRDGYEsSYRRRTL X X -PLK1 PLK1 P53350 human CENPQ 55166 Q7L2Z9 CENPQ human S138 18007846 MEDLtNVssLLNMER CENP-Q X X -PLK1 PLK1 P53350 human CTNNB1 1499 P35222 CTNNB1 human S311 1881000308 LAYGNQEsKLIILAS X X -PLK1 PLK1 P53350 human TTK 7272 P33981 TTK human T594 41389700 RLYDYEItDQYIYMV Pkinase X -PLK1 PLK1 P53350 human KLF4 9314 O43474 KLF4 human S234 31081924 GkFVLkAsLsAPGSE X X -PLK1 PLK1 P53350 human SynGAP iso3 192117 Q9QUH6-3 Syngap1 rat S836 4792755 AGRLSQGsGSSITAA DUF3498 X -PLK1 PLK1 P53350 human RASGRF1 192213 P28818 Rasgrf1 rat S575 18710202 QEKAAWTsDIIQCVD PH X -PLK1 PLK1 P53350 human CENPQ 55166 Q7L2Z9 CENPQ human T256 40245502 sQMKsMstFIEEAYK CENP-Q X X -PLK1 PLK1 P53350 human TTK 7272 P33981 TTK human S321 3189826 SkPsGNDsCELRNLk X -PLK1 PLK1 P53350 human BRCA1 672 P38398 BRCA1 human S1164 36135579 GEIKEDTsFAENDIk X X -PLK1 PLK1 P53350 human APC1 64682 Q9H1A4 ANAPC1 human S377 455827 NIssHNQsPkRHSIS X -PLK1 PLK1 P53350 human MST2 6788 Q13188 STK3 human T384 3195191 GtMKRNAtsPQVQRP X -PLK1 PLK1 P53350 human SynGAP iso3 192117 Q9QUH6-3 Syngap1 rat S326 4792707 GsGGGGGsGGGSGGK X -PLK1 PLK1 P53350 human LRRK1 79705 Q38SD2 LRRK1 human S1817 41694201 GDSIADVsIMYSEEL X X -PLK1 PLK1 P53350 human TTK 7272 P33981 TTK human S108 41389701 DkYGQNEsFARIQVR X -PLK1 PLK1 P53350 human CENPQ 55166 Q7L2Z9 CENPQ human S253 23092802 HNssQMKsMstFIEE CENP-Q X X -PLK1 PLK1 P53350 human APC7 51434 Q9UJX3 ANAPC7 human S23 455842 HsNVRLLssLLLtMs X -PLK1 PLK1 P53350 human TTK 7272 P33981 TTK human T458 15428764 CktPsSNtLDDyMsC X -PLK1 PLK1 P53350 human CEP68 23177 Q76N32 CEP68 human S332 37046602 ADPVLQDsGVDLDSF X X -PLK1 PLK1 P53350 human PPP1R7 5510 Q15435 PPP1R7 human S44 468497 sGIVADLsEQsLkDG X -PLK1 PLK1 P53350 human TTK 7272 P33981 TTK human T12 13194901 DLsGRELtIDsIMNk X -PLK1 PLK1 P53350 human NFL 18039 P08551 Nefl mouse S473 450895 EAKDEPPsEGEAEEE X -PLK1 PLK1 P53350 human NEDD1 121441 Q8NHV4 NEDD1 human S426 9379002 VNKGsDEsIGkGDGF X -PLK1 PLK1 P53350 human TTK 7272 P33981 TTK human S333 41389702 NLkSVQNsHFkEPLV X -PLK1 PLK1 P53350 human MAD1L1 8379 Q9Y6D9 MAD1L1 human S22 5024704 RsLNNFIsQRVEGGs X -PLK1 PLK1 P53350 human PPP1R7 5510 Q15435 PPP1R7 human S27 465871 RRVEsEEsGDEEGKk X -PLK1 PLK1 P53350 human CASP8 841 Q14790 CASP8 human S305 31894302 IYQLMDHsNMDCFIC Peptidase_C14 X X -PLK1 PLK1 P53350 human USP16 10600 Q9Y5T5 USP16 human S386 50592104 HESFLDLsLPVLDDQ UCH X X -PLK1 PLK1 P53350 human NCAPH2 29781 Q6IBW4 NCAPH2 human S288 36136891 EsRsPQQsAALPRRY X X -PLK1 PLK1 P53350 human PPP1R7 5510 Q15435 PPP1R7 human S24 465870 EVDRRVEsEEsGDEE X -PLK1 PLK1 P53350 human FOXM1 2305 Q08050 FOXM1 human S739 18009877 SKILLDIsFPGLDED X X -PLK1 PLK1 P53350 human DYNC1I2 116659 Q62871 Dync1i2 rat T95 469264 PssKSVstPsEAGsQ X -PLK1 PLK1 P53350 human Vimentin 22352 P20152 Vim mouse S83 451816 GVRLLQDsVdFsLAD Filament_head X X 3878; 12569 -PLK1 PLK1 P53350 human MEK1 5604 Q02750 MAP2K1 human S222 448513 LIDsMANsFVGtRSY Pkinase X 2338; 9121; 3958; 9154; 16211; 86128; 16780; 75262 -PLK1 PLK1 P53350 human PCNT 5116 O95613 PCNT human S1235 25617500 MSSVAEIsSHMREsF X -PLK1 PLK1 P53350 human PRC1 9055 O43663 PRC1 human S615 4274308 ATSGILNstNIQs__ X -PLK1 PLK1 P53350 human CDC6 990 Q99741 CDC6 human T37 17481900 SDAkLEPtNVQTVtC X X -PLK1 PLK1 P53350 human CENPQ 55166 Q7L2Z9 CENPQ human S249 3850352 LDILHNssQMKsMst CENP-Q X X -PLK1 PLK1 P53350 human Vimentin 7431 P08670 VIM human T336 31863396 EVdALkGtNEsLERQ Filament X -PLK1 PLK1 P53350 human CCNB1 891 P14635 CCNB1 human S126 448814 PILVDTAsPsPMETs X X -PLK1 PLK1 P53350 human MgcRacGAP 29127 Q9H0H5 RACGAP1 human S164 459864 sFDKtDEsLDWDssL X X -PLK1 PLK1 P53350 human FOXM1 iso2 2305 Q08050-2 FOXM1 human S724 18009877 SKILLDIsFPGLDED X X -PLK1 PLK1 P53350 human NCAPD3 23310 P42695 NCAPD3 human S1419 19009802 AIstPEKsISDVtFG X X -PLK1 PLK1 P53350 human TTK 7272 P33981 TTK human S291 31862439 CDVktDDsVVPCFMK X -PLK1 PLK1 P53350 human PAX3-FOXO1 2308 AAC50053 PAX3/FOXO1 human S503 37038800 PRTSSNAsTISGRLs X X -PLK1 PLK1 P53350 human axin 2 8313 Q9Y2T1 AXIN2 human S311 53439300 SDALTDDsMSMTDSS X X -PLK1 PLK1 P53350 human RAD21 5885 O60216 RAD21 human S175 474523 REIMREGsAFEDDDM X -PLK1 PLK1 P53350 human MDC1 9656 Q14676 MDC1 human T4 3965656 ____MEDtQAIDWDV X X -PLK1 PLK1 P53350 human TTK 7272 P33981 TTK human T371 1737600 LLAkLEEtkEyQEPE X -PLK1 PLK1 P53350 human CELSR1 12614 O35161 Celsr1 mouse S2741 27446069 KKLQLDDsATTRATL X -PLK1 PLK1 P53350 human BRCA2 675 P51587 BRCA2 human S205 469575 LATPPtLsstVLIVR X -PLK1 PLK1 P53350 human GTF3B 2972 Q92994 BRF1 human S450 3208533 GDGELDLsGIDDLEI BRF1 X -PLK1 PLK1 P53350 human TNKS 8658 O95271 TNKS human T930 21326700 LAHGADPtMkNQEGQ Ank_5 X X -PLK1 PLK1 P53350 human YY1 7528 P25490 YY1 human T39 18264901 PVETIETtVVGEEEE X X -PLK1 PLK1 P53350 human WDCP 80304 Q9H6R7 WDCP human S686 3212568 RsDVFRDsFsHsPGA X X -PLK1 PLK1 P53350 human RASGRF1 192213 P28818 Rasgrf1 rat S760 18710206 LASLGCPsDGYTNIH X -PLK1 PLK1 P53350 human CDC25B 994 P30305 CDC25B human S465 20503411 PLERDAEsFLLksPI Rhodanese X -PLK1 PLK1 P53350 human NuaK1 9891 O60285 NUAK1 human S480 33406501 QREsGYYsSPERSES X -PLK1 PLK1 P53350 human 53BP1 7158 Q12888 TP53BP1 human S1618 3194894 LtkAADIsLDNLVEG X X 6209 -PLK1 PLK1 P53350 human Vimentin 7431 P08670 VIM human S83 451816 GVRLLQDsVdFsLAd Filament_head X X 3878; 12569 -PLK1 PLK1 P53350 human CDC23 8697 Q9UJX2 CDC23 human T562 454344 QLRNQGEtPttEVPA X -PLK1 PLK1 P53350 human SUZ12 23512 Q15022 SUZ12 human S539 4746706 RPKRTkAsMsEFLEs X -PLK1 PLK1 P53350 human MEK1 5604 Q02750 MAP2K1 human S218 448514 VsGQLIDsMANsFVG Pkinase X 9121; 3958; 9154; 86128 -PLK1 PLK1 P53350 human BRCA2 675 P51587 BRCA2 human S193 469574 AEVDPDMsWSSSLAT X X -PLK1 PLK1 P53350 human MST2 6788 Q13188 STK3 human S15 4272103 KSKLKkLsEDsLTkQ X X -PLK1 PLK1 P53350 human CENPU 79682 Q71F23 CENPU human S77 471407 TFDPPLHstAIyADE X X -PLK1 PLK1 P53350 human CDC27 996 P30260 CDC27 human T430 455860 INDsLEItkLDssII X -PLK1 PLK1 P53350 human Chk2 11200 O96017 CHEK2 human T205 12473001 VFVFFDLtVDDQsVY X -PLK1 PLK1 P53350 human KIF2C 11004 Q99661 KIF2C human S632 5829783 EELSsQMssFNEAMT X -PLK1 PLK1 P53350 human Wee1 7465 P30291 WEE1 human S53 451131 GHstGEDsAFQEPDS X -PLK1 PLK1 P53350 human Vimentin 7431 P08670 VIM human S459 470128 GQVINEtsQHHDDLE X X -PLK1 PLK1 P53350 human LSD1 23028 O60341 KDM1A human S126 3175618 EYREMDEsLANLsED X X -PLK1 PLK1 P53350 human CDC23 8697 Q9UJX2 CDC23 human T565 455847 NQGEtPttEVPAPFF X -PLK1 PLK1 P53350 human TTK 7272 P33981 TTK human T676 487540 NQMQPDttsVVkDSQ Pkinase X X -PLK1 PLK1 P53350 human RIOK2 55781 Q9BVS4 RIOK2 human S548 21241902 KSSLEAAsFWGE___ X X -PLK1 PLK1 P53350 human RAPGEF2 iso2 9693 Q17RH5 RAPGEF2 human S794 18710214 RECKNFNsMFAIISG RasGEF X -PLK1 PLK1 P53350 human CELSR1 12614 O35161 Celsr1 mouse S2752 31884511 RATLLtRsLNCNNTY X -PLK1 PLK1 P53350 human DZIP1 66573 Q8BMD2 Dzip1 mouse S210 62403301 QRRHTEDsHLEYNTK X -PLK1 PLK1 P53350 human p73 7161 O15350 TP73 human T27 2063601 SSLEPDStyFDLPQS X X -PLK1 PLK1 P53350 human TSC1 7248 Q92574 TSC1 human S579 911089200 CQTSLETsIFTPsPC Hamartin X X -PLK1 PLK1 P53350 human RUVBL1 8607 Q9Y265 RUVBL1 human T239 41608704 kEIIQDVtLHDLDVA TIP49 X -PLK1 PLK1 P53350 human CEP55 55165 Q53EZ4 CEP55 human S436 457630 PtAALNEsLVECPkC X X -PLK1 PLK1 P53350 human SynGAP iso3 192117 Q9QUH6-3 Syngap1 rat S320 4792701 GGSGGMGsGGGGGsG X X -PLK1 PLK1 P53350 human CDC25B 994 P30305 CDC25B human S375 455380 ARVLRsksLCHDEIE M-inducer_phosp X -PLK1 PLK1 P53350 human NDR1 11329 Q15208 STK38 human T183 41425402 TLLMKKDtLTEEETQ Pkinase X X -PLK1 PLK1 P53350 human MgcRacGAP 29127 Q9H0H5 RACGAP1 human T260 7652108 QPWNsDstLNSRQLE X -PLK1 PLK1 P53350 human Bcl-xL 598 Q07817 BCL2L1 human S62 449099 PSWHLADsPAVNGAT X -PLK1 PLK1 P53350 human TRF1 7013 P54274 TERF1 human S435 3192037 KKLKLIssDsED___ X X -PLK1 PLK1 P53350 human PICH 54821 Q2NKX8 ERCC6L human T1063 474544 VKQFDAstPkNDIsP X X -PLK1 PLK1 P53350 human NUDC 10726 Q9Y266 NUDC human S326 451057 QHPEMDFskAkFN__ X X -PLK1 PLK1 P53350 human Vimentin 7431 P08670 VIM human T327 3180351 RRQVQsLtCEVdALk Filament X X -PLK1 PLK1 P53350 human CCDC141 545428 E9Q8Q6 Ccdc141 mouse T91 1874043200 LLREADRtAEANKAQ X -PLK1 PLK1 P53350 human KIF23 71819 E9Q5G3 Kif23 mouse S905 459841 GSRKRRsstLAPAQP X -PLK1 PLK1 P53350 human SNCB 6620 Q16143 SNCB human S118 448525 LMEPEGEsYEDPPQE Synuclein X X -PLK1 PLK1 P53350 human SGO1 72415 Q9CXH7 Sgo1 mouse S73 2535906 LALENEKsKVREAQD X -PLK1 PLK1 P53350 human TNKS 8658 O95271 TNKS human T839 21326702 DTQGRNStPLHLAAG Ank_4 X X -PLK1 PLK1 P53350 human Kizuna 55857 Q2M2Z5 KIZ human T379 469605 WSTSSDLtISISEDD X X -PLK1 PLK1 P53350 human BRCA2 675 P51587 BRCA2 human S206 469576 ATPPtLsstVLIVRN X -PLK1 PLK1 P53350 human RAPGEF2 iso2 9693 Q17RH5 RAPGEF2 human S1164 18710215 DERRQRHsVSIVETN X -PLK1 PLK1 P53350 human CtIP 5932 Q99708 RBBP8 human T693 1868101003 ETVDMDCtLVSETVL X -PLK1 PLK1 P53350 human FBX5 67141 Q7TSG3 Fbxo5 mouse S124 456211 ASRLYEDsGYSsFTQ X -PLK1 PLK1 P53350 human PINX1 54984 Q96BK5 PINX1 human S110 14823406 SDKKEKKsFSLEEKs X X -PLK1 PLK1 P53350 human FBX5 67141 Q7TSG3 Fbxo5 mouse S128 456212 YEDsGYSsFTQSDRD X -PLK1 PLK1 P53350 human SUZ12 23512 Q15022 SUZ12 human S546 449173 sMsEFLEsEDGEVEQ VEFS-Box X -PLK1 PLK1 P53350 human MAD1L1 8379 Q9Y6D9 MAD1L1 human S29 5024705 sQRVEGGsGLDISTS X -PLK1 PLK1 P53350 human CELSR1 12614 O35161 Celsr1 mouse T2750 41159600 TTRATLLtRsLNCNN X -PLK1 PLK1 P53350 human HSF1 3297 Q00613 HSF1 human S419 455264 SALLDLFsPSVTVPD Vert_HS_TF X -PLK1 PLK1 P53350 human MEK2 5605 P36507 MAP2K2 human S222 448073 VsGQLIDsMANsFVG Pkinase X 9121; 3958; 9154; 86128 -PLK1 PLK1 P53350 human SUGT1 67955 Q9CX34 Sugt1 mouse S302 18016406 VKRAMNKsFMESGGT SGS X X -PLK1 PLK1 P53350 human Nlp 22981 Q9Y2I6 NINL human S87 451060 VRPSDEDssSLESAA X -PLK1 PLK1 P53350 human CDC25B 994 P30305 CDC25B human S397 20503409 RELIGDYskAFLLQt X -PLK1 PLK1 P53350 human RAPGEF2 iso2 9693 Q17RH5 RAPGEF2 human S921 4737718 KKWRSLGsLSQGSTN X -PLK1 PLK1 P53350 human PPP1R7 5510 Q15435 PPP1R7 human T277 57812709 LENNNKLtMLDIASN LRR_9 X -PLK1 PLK1 P53350 human CLASP2 23122 O75122 CLASP2 human S1027 7320226 NPyNysDsIsPFNKs X X -PLK1 PLK1 P53350 human Restin 6249 P30622 CLIP1 human S195 468616 LtKtAsEsIsNLsEA X X -PLK1 PLK1 P53350 human CDC27 996 P30260 CDC27 human S435 455862 EItkLDssIIsEGkI X -PLK1 PLK1 P53350 human YAP1 10413 P46937 YAP1 human T77 126835301 NAVMNPktANVPQtV X -PLK1 PLK1 P53350 human TEX14 56155 Q8IWB6 TEX14 human S437 25158900 QKAATVKsDIYSFSM PK_Tyr_Ser-Thr X -PLK1 PLK1 P53350 human CCNB1 891 P14635 CCNB1 human S147 448446 EDLCQAFsDVILAVN X X 4131 -PLK1 PLK1 P53350 human SNCA 6622 P37840 SNCA human S129 448278 NEAyEMPsEEGyQDy Synuclein X X 23706; 87281 -PLK1 PLK1 P53350 human MgcRacGAP 29127 Q9H0H5 RACGAP1 human S157 3211992 GsILsDIsFDKtDEs X X -PLK1 PLK1 P53350 human SynGAP iso3 192117 Q9QUH6-3 Syngap1 rat S781 18710211 KMLsVNKsVsMLDLQ DUF3498 X -PLK1 PLK1 P53350 human CENPQ 55166 Q7L2Z9 CENPQ human S139 31868909 EDLtNVssLLNMERA CENP-Q X X -PLK1 PLK1 P53350 human FIRRM 55732 Q9NSG2 FIRRM human S744 50774549 ETKNKVVsFLEkTGF X -PLK1 PLK1 P53350 human CDC25B 994 P30305 CDC25B human S353 452008 VQNkRRRsVtPPEEQ M-inducer_phosp X -PLK1 PLK1 P53350 human Notch 1 4851 P46531 NOTCH1 human S1791 27457604 REPLGEDsVGLkPLK X X -PLK1 PLK1 P53350 human CDC25B 994 P30305 CDC25B human T127 20503410 DPHMAEQtFEQAIQA M-inducer_phosp X -PLK1 PLK1 P53350 human TTK 7272 P33981 TTK human T210 41389703 LSASTVLtAQEsFsG X -PLK1 PLK1 P53350 human TTK 7272 P33981 TTK human S214 14161585 TVLtAQEsFsGsLGH X -PLK1 PLK1 P53350 human CDC25B 994 P30305 CDC25B human T265 20503406 LTPAEGDtEEDDGFV M-inducer_phosp X -PLK1 PLK1 P53350 human KIF2C 11004 Q99661 KIF2C human S633 5779213 ELSsQMssFNEAMTQ X -PLK1 PLK1 P53350 human IRS1 3667 P35568 IRS1 human S24 455604 GYLRKPKsMHKRFFV PH X -PLK1 PLK1 P53350 human TPT1 22070 P63028 Tpt1 mouse S64 3146607 PEGEGTEsTVVTGVD TCTP X -PLK1 PLK1 P53350 human CENPQ 55166 Q7L2Z9 CENPQ human S255 40245504 ssQMKsMstFIEEAY CENP-Q X X -PLK1 PLK1 P53350 human PCNT 5116 O95613 PCNT human S1241 25617501 IsSHMREsFLMsPES X -PLK1 PLK1 P53350 human TTK 7272 P33981 TTK human S362 13194902 TLKNktEssLLAkLE X -PLK1 PLK1 P53350 human Rb 5925 P06400 RB1 human S758 1878197600 SIIVFYNsVFMQRLK X X -PLK1 PLK1 P53350 human CtIP 5932 Q99708 RBBP8 human S723 4766312 EERKMNDsLEDMFDR X X -PLK1 PLK1 P53350 human SUZ12 23512 Q15022 SUZ12 human S541 3208749 KRTkAsMsEFLEsED X -PLK1 PLK1 P53350 human RIOK2 55781 Q9BVS4 RIOK2 human S335 471042 TKEGsEFsFsDGEVA X X -PLK1 PLK1 P53350 human MRE11A 4361 P49959 MRE11 human S688 449207 sKGVDFEssEDDDDD X -PLK1 PLK1 P53350 human KIF2A 3796 O00139 KIF2A human T554 40240801 ANRVKELtVDPTAAG X -PLK1 PLK1 P53350 human optineurin 10133 Q96CV9 OPTN human S177 4762451 ssGssEDsFVEIRMA X X 31304; 57548 -PLK1 PLK1 P53350 human APC1 64682 Q9H1A4 ANAPC1 human S373 455826 VQRFNIssHNQsPkR X -PLK1 PLK1 P53350 human claspin 63967 Q9HAW4 CLSPN human S30 467250 EADSPSDsGQGsYET X -PLK1 PLK1 P53350 human TTK 7272 P33981 TTK human S345 41157083 PLVSDEKsSELIItD X -PLK1 PLK1 P53350 human PIN1 5300 Q13526 PIN1 human S65 456481 sHLLVkHsQSRRPss Rotamase X X -PLK1 PLK1 P53350 human separase 9700 Q14674 ESPL1 human S1399 1211206 KVNFsDDsDLEDPVS X -PLK1 PLK1 P53350 human FBX5 26271 Q9UKT4 FBXO5 human S149 456212 yEDsGYSsFSLQSGL X -PLK1 PLK1 P53350 human SynGAP iso3 192117 Q9QUH6-3 Syngap1 rat S783 18710212 LsVNKsVsMLDLQGD DUF3498 X -PLK1 PLK1 P53350 human RASGRF1 192213 P28818 Rasgrf1 rat S71 18710203 GLYLLEGsICKRMPS PH X -PLK1 PLK1 P53350 human APC7 51434 Q9UJX3 ANAPC7 human S17 455841 MAAAGLHsNVRLLss X -PLK1 PLK1 P53350 human RAP1GAP 5909 P47736 RAP1GAP human S525 450258 AGQKtPDsGHVSQEP X X -PLK1 PLK1 P53350 human APC1 64682 Q9H1A4 ANAPC1 human S547 455831 PLsKLLGsLDEVVLL X -PLK1 PLK1 P53350 human APC1 64682 Q9H1A4 ANAPC1 human S688 452953 FDFEGsLsPVIAPkk Apc1_MidN X -PLK1 PLK1 P53350 human CIP2A 57650 Q8TCG1 CIP2A human S904 482834 NPETVNLsI______ X -PLK1 PLK1 P53350 human RAPGEF2 iso2 9693 Q17RH5 RAPGEF2 human T632 18710213 AIREFAVtATPDQYS RA X X -PLK1 PLK1 P53350 human TNKS 8658 O95271 TNKS human S978 471333 VVSASLIsPAStPSC X X -PLK1 PLK1 P53350 human Survivin 332 O15392 BIRC5 human S20 485776 FLkDHRIstFkNWPF BIR X X -PLK1 PLK1 P53350 human IKKB 3551 O14920 IKBKB human S740 5014909 sFtALDWsWLQTEEE IKKbetaNEMObind X X -PLK1 PLK1 P53350 human GTSE1 51512 Q9NYZ3 GTSE1 human S454 10405611 RsIRRRDsCLNsKTK X X -PLK1 PLK1 P53350 human ZNF198 7750 Q9UBW7 ZMYM2 human S303 18914809 QkQPGVDsLsPVAsL X -PLK1 PLK1 P53350 human axin 1 12005 O35625 Axin1 mouse S157 27266401 LDsNGIVsRQtKPAT RGS X X -PLK1 PLK1 P53350 human CDC27 996 P30260 CDC27 human T205 455848 PEtVLtEtPQDtIEL X -PLK1 PLK1 P53350 human PTP1B 5770 P18031 PTPN1 human S286 27528603 KFIMGDSsVQDQWKE X -PLK1 PLK1 P53350 human USP16 10600 Q9Y5T5 USP16 human S330 29614602 ILKAFGNsTEkLDEE UCH X X -PLK1 PLK1 P53350 human RAPGEF2 iso2 9693 Q17RH5 RAPGEF2 human S1010 1984206 KPVKSETsPVAPRAG X -PLK1 PLK1 P53350 human PLEKHG6 55200 Q3KR16 PLEKHG6 human T574 4145508 HLVVTEDtDEDAPLV X X -PLK1 PLK1 P53350 human CENPQ 55166 Q7L2Z9 CENPQ human S248 40245501 DLDILHNssQMKsMs CENP-Q X X -PLK1 PLK1 P53350 human Tara iso5 11078 Q9H2D6-5 TRIOBP human T457 27171500 QAEEREHtLRRCQQE X X -PLK1 PLK1 P53350 human WDCP 80304 Q9H6R7 WDCP human S695 31855763 sHsPGAVssLKVFTG X X -PLK1 PLK1 P53350 human KIF2B 84643 Q8N4N8 KIF2B human S204 25247528 HLDssKIsVLEPPQE X X -PLK1 PLK1 P53350 human PARK2 5071 O60260 PRKN human S378 454424 AyHEGECsAVFEASG X -PLK1 PLK1 P53350 human CtIP 5932 Q99708 RBBP8 human T731 1868101002 LEDMFDRtTHEEYES X -PLK1 PLK1 P53350 human CTNNB1 1499 P35222 CTNNB1 human S718 5403101 QDDPsyRsFHsGGyG X X -PLK1 PLK1 P53350 human SUN1 iso9 23353 O94901-9 SUN1 human S138 470335 RPPVLDEsWIREQTT MRP X X -PLK1 PLK1 P53350 human Notch 1 4851 P46531 NOTCH1 human S2439 1875193400 SFLSGEPsQADVQPL X X -PLK1 PLK1 P53350 human RIOK2 55781 Q9BVS4 RIOK2 human S380 3211080 PEQIkEdsLsEEsAD X X -PLK1 PLK1 P53350 human NPM1 4869 P06748 NPM1 human S4 452023 ____MEDsMDMDMsP X X 3520 -PLK1 PLK1 P53350 human MDC1 9656 Q14676 MDC1 human T847 30996100 PERQTDVtGEEELTK X X -PLK1 PLK1 P53350 human AurB 9212 Q96GD4 AURKB human T236 4164705 RRktMCGtLDyLPPE Pkinase X X -PLK1 PLK1 P53350 human MST2 6788 Q13188 STK3 human T336 3801535 TSVEsVGtMRATSTM X -PLK1 PLK1 P53350 human FADD 8772 Q13158 FADD human S194 447653 QNRsGAMsPMsWNsD X X 2781 -PLK1 PLK1 P53350 human CDC25B 994 P30305 CDC25B human S513 20503413 RAVNDYPsLYYPEMY Rhodanese X -PLK1 PLK1 P53350 human USP16 10600 Q9Y5T5 USP16 human S486 50592105 SEYEAEMsLQGEVNI UCH X -PLK1 PLK1 P53350 human KIF2B 84643 Q8N4N8 KIF2B human S201 25247534 YRRHLDssKIsVLEP X -PLK1 PLK1 P53350 human GTF3B 2972 Q92994 BRF1 human T270 22996307 RLTEFEDtPTSQLTI TFIIB X -PLK1 PLK1 P53350 human MgcRacGAP 29127 Q9H0H5 RACGAP1 human S149 3211986 RLstIDEsGsILsDI X -PLK1 PLK1 P53350 human CDC25C 995 P30307 CDC25C human S198 448636 sDELMEFsLKDQEAK M-inducer_phosp X X 9529 -PLK1 PLK1 P53350 human GRASP65 64689 Q9BQQ3 GORASP1 human S189 25247500 AAWGGEGsLGCGIGY GRASP55_65 X -PLK1 PLK1 P53350 human BRCA2 675 P51587 BRCA2 human T207 469578 TPPtLsstVLIVRNE X X -PLK1 PLK1 P53350 human PLK1 5347 P53350 PLK1 human T210 448139 YDGERKktLCGtPNy Pkinase X 4354; 5472; 9062 -PLK1 PLK1 P53350 human ACTB 60 P60709 ACTB human S239 3147240 SsSsLEksyELPDGQ Actin X -PLK1 PLK1 P53350 human separase 9700 Q14674 ESPL1 human T1363 1211205 AGPHVPFtVFEEVCP X -PLK1 PLK1 P53350 human ataxin-10 25814 Q9UBB4 ATXN10 human T82 21514208 ASsLQLItECFRCLR X X -PLK1 PLK1 P53350 human MgcRacGAP 29127 Q9H0H5 RACGAP1 human S170 459865 EsLDWDssLVkTFKL X X -PLK1 PLK1 P53350 human CDC25B 994 P30305 CDC25B human S291 20503408 AVPPGMEsLISAPLV M-inducer_phosp X -PLK1 PLK1 P53350 human MYST2 11143 O95251 KAT7 human S57 460899 sQssQDssPVRNLQs X X -PLK1 PLK1 P53350 human GTSE1 51512 Q9NYZ3 GTSE1 human S242 14881300 LLLPRAAsVRGRsIP X -PLK1 PLK1 P53350 human REST 5978 Q13127 REST human S1030 37042902 MsEGsDDsGLHGARP X X -PLK1 PLK1 P53350 human Restin 6249 P30622 CLIP1 human S1364 3189736 DDLNNYDsDDQEKQS X -PLK1 PLK1 P53350 human MTHFR 4524 P42898 MTHFR human T549 178601701 NVKGENItNAPELQP X X -PLK1 PLK1 P53350 human STIL 6491 Q15468 STIL human S1108 17549173 DRSTVGLsLIsPNNM X X -PLK1 PLK1 P53350 human APC4 29945 Q9UJX5 ANAPC4 human S779 455839 kEEVLsEsEAENQQA X -PLK1 PLK1 P53350 human TSC1 7248 Q92574 TSC1 human S468 36132604 GFLGDLAsEEDsIEK Hamartin X -PLK1 PLK1 P53350 human BUB1B 701 O60566 BUB1B human T1008 7652107 LNANDEAtVSVLGEL X X -PLK1 PLK1 P53350 human APC1 64682 Q9H1A4 ANAPC1 human T291 455824 kFsEQGGtPQNVATS X -PLK1 PLK1 P53350 human CCNB1 891 P14635 CCNB1 human S133 448445 sPsPMETsGCAPAEE X X 4133 -PLK1 PLK1 P53350 human TNKS 8658 O95271 TNKS human T1128 21326701 VEEEMQStIREHRDG PARP X X -PLK1 PLK1 P53350 human CENPU 79682 Q71F23 CENPU human T78 471408 FDPPLHstAIyADEE X X -PLK1 PLK1 P53350 human CTNNB1 12387 Q02248 Ctnnb1 mouse S60 1875093002 EEEDVDTsQVLYEWE X X -PLK1 PLK1 P53350 human PINX1 54984 Q96BK5 PINX1 human S117 14823407 sFSLEEKsKISKNRV X X -PLK1 PLK1 P53350 human SynGAP iso3 192117 Q9QUH6-3 Syngap1 rat S407 18710210 GKAKDFLsDMAMSEV RasGAP X -PLK1 PLK1 P53350 human Nlp 22981 Q9Y2I6 NINL human T161 451058 SDEEAEStKEAQNEL X -PLK1 PLK1 P53350 human NEDD1 121441 Q8NHV4 NEDD1 human T382 9379001 PRsINTDtLSkEtDs X -PLK1 PLK1 P53350 human MST2 6788 Q13188 STK3 human S18 20831306 LKkLsEDsLTkQPEE X X -PLK1 PLK1 P53350 human NKX2-1 21869 P50220 Nkx2-1 mouse S23 21478902 ILSPLEEsYKKVGME X X -PLK1 PLK1 P53350 human NUDC 10726 Q9Y266 NUDC human S274 451056 kkINPENskLsDLDs X X -PLK1 PLK1 P53350 human IKKB 3551 O14920 IKBKB human S750 5014910 QTEEEEHsCLEQAS_ X -PLK1 PLK1 P53350 human ROCK2 282041 Q28021 ROCK2 cow T967 1732201 ELTEKDAtIASLEET X -PLK1 PLK1 P53350 human APC7 51434 Q9UJX3 ANAPC7 human S30 455843 ssLLLtMsNNNPELF X -PLK1 PLK1 P53350 human CEP192 55125 Q8TEP8 CEP192 human T44 41159607 GLPVAVStLARDRSS X -PLK1 PLK1 P53350 human Myt1 9088 Q99640 PKMYT1 human T495 449339 LLSLFEDtLDPT___ X X -PLK1 PLK1 P53350 human FOXM1 2305 Q08050 FOXM1 human S730 3194570 VLDTMNDsLSKILLD X X -PLK1 PLK1 P53350 human PINX1 54984 Q96BK5 PINX1 human T141 14823403 DLSSRSKtDLDCIFG X X -PLK1 PLK1 P53350 human WDR62 284403 O43379 WDR62 human S897 291887111 KPESLENsILDSLEP X -PLK1 PLK1 P53350 human TPT1 22070 P63028 Tpt1 mouse S46 476067 TEGAIDDsLIGGNAs TCTP X 5251 -PLK1 PLK1 P53350 human TTK 7272 P33981 TTK human T564 4145511 LEEADNQtLDSYRNE Pkinase X -PLK1 PLK1 P53350 human TOP2A 7153 P11388 TOP2A human S1337 477804 LDsDEDFsDFDEKtD X X -PLK1 PLK1 P53350 human CDC25B 994 P30305 CDC25B human T404 20503407 skAFLLQtVDGkHQD X -PLK1 PLK1 P53350 human ZNF198 7750 Q9UBW7 ZMYM2 human S309 17434113 DsLsPVAsLPkQIFQ X -PLK1 PLK1 P53350 human CTNNB1 1499 P35222 CTNNB1 human S60 1875093002 EEEDVDTsQVLyEWE X X -PLK1 PLK1 P53350 human Myc 4609 P01106 MYC human S77 448586 LLPtPPLsPsRRsGL Myc_N X 13748 -PLK1 PLK1 P53350 human APC1 64682 Q9H1A4 ANAPC1 human S355 455825 AALsrAHsPALGVHs X -PLK1 PLK1 P53350 human TTK 7272 P33981 TTK human S37 2846500 EDLtDELsLNKISAD X -PLK1 PLK1 P53350 human PARP10 84875 Q53GL7 PARP10 human T601 31905435 EVRELLAtLEGLDLD X X -PLK1 PLK1 P53350 human DNAPK 5591 P78527 PRKDC human S3205 452351 tPLPEDNsMNVDQDG FAT X X -PLK1 PLK1 P53350 human KIF23 71819 E9Q5G3 Kif23 mouse S904 459840 TGSRKRRsstLAPAQ X -PLK1 PLK1 P53350 human PPP1R7 5510 Q15435 PPP1R7 human S47 468498 VADLsEQsLkDGEEr X -PLK1 PLK1 P53350 human HSP70 3303 P0DMV8 HSPA1B human S631 483567 AQGPkGGsGsGPtIE X -PLK1 PLK1 P53350 human Chk2 11200 O96017 CHEK2 human T68 447491 SsLEtVstQELYsIP X X 2197; 2661; 28130; 12812; 82263; 64180; 59068 -PLK1 PLK1 P53350 human FBX5 26271 Q9UKT4 FBXO5 human S145 456211 TSRLyEDsGYSsFSL X -PLK1 PLK1 P53350 human KIF2B 84643 Q8N4N8 KIF2B human S200 25247531 EYRRHLDssKIsVLE X -PLK1 PLK1 P53350 human CDC27 996 P30260 CDC27 human S434 455861 LEItkLDssIIsEGk X -PLK1 PLK1 P53350 human GLI1 14632 P47806 Gli1 mouse S481 1412327901 GGSTEDLsSLDEGPC X X -PLK1 PLK1 P53350 human Chk2 11200 O96017 CHEK2 human S164 12473002 IAYIEDHsGNGTFVN FHA X -PLK1 PLK1 P53350 human CENPQ 55166 Q7L2Z9 CENPQ human T135 40245505 PKkMEDLtNVssLLN CENP-Q X X -PLK1 PLK1 P53350 human TTK 7272 P33981 TTK human S363 1737601 LKNktEssLLAkLEE X -PLK1 PLK1 P53350 human supervillin 6840 O95425 SVIL human S238 468886 sFSGRDssFtEVPRs X X -PLK1 PLK1 P53350 human CDC25B 994 P30305 CDC25B human S50 20503402 PVRAAASsPVttLtQ X -PLK1 PLK1 P53350 human CCNB1 891 P14635 CCNB1 human S128 448815 LVDTAsPsPMETsGC X X -PLK1 PLK1 P53350 human BRCA2 675 P51587 BRCA2 human T203 469577 SSLATPPtLsstVLI X -PLK1 PLK1 P53350 human BUB1B 701 O60566 BUB1B human T792 7652106 PRNSAELtVIKVsSQ X X -PLK1 PLK1 P53350 human CDCA5 113130 Q96FF9 CDCA5 human T151 28750703 RsysRLEtLGsASts Sororin X -PLK1 PLK1 P53350 human SAPS2 9701 O75170 PPP6R2 human S289 3176005 GtEGLVDsFsQGLER SAPS X -PLK1 PLK1 P53350 human AMPKA2 5563 P54646 PRKAA2 human T172 448026 sDGEFLRtsCGsPNy Pkinase X 2535; 2531; 5256; 50081; 74281 -PLK1 PLK1 P53350 human Myt1 9088 Q99640 PKMYT1 human S426 449338 CSLLLDSsLSSNWDD X X -PLK1 PLK1 P53350 human Vimentin 7431 P08670 VIM human S339 14582709 ALkGtNEsLERQMRE Filament X X -PLK1 PLK1 P53350 human ZNF198 7750 Q9UBW7 ZMYM2 human S305 483897 QPGVDsLsPVAsLPk X -PLK1 PLK1 P53350 human RAD21 5885 O60216 RAD21 human S454 474526 EPsRLQEsVMEAsRT X -PLK1 PLK1 P53350 human MgcRacGAP 29127 Q9H0H5 RACGAP1 human S214 459867 AVDQGNEsIVAKTTV X -PLK1 PLK1 P53350 human RASGRF1 192213 P28818 Rasgrf1 rat S611 18710207 QMIKSDAsLYCDDVD X -PLK1 PLK1 P53350 human ataxin-10 25814 Q9UBB4 ATXN10 human S77 21514207 QVENLASsLQLItEC X X -PLK1 PLK1 P53350 human CDC25B 994 P30305 CDC25B human T167 20503412 sPVLRNItNsQAPDG M-inducer_phosp X -PLK1 PLK1 P53350 human RAN 5901 P62826 RAN human S135 469112 DRkVKAksIVFHRkk Ras X X -PLK1 PLK1 P53350 human SUGT1 10910 Q9Y2Z0 SUGT1 human S331 18016406 VkRAMNksFMEsGGt SGS X -PLK1 PLK1 P53350 human KIF2C 11004 Q99661 KIF2C human S621 18011291 ALIPGNLsKEEEELS X -PLK1 PLK1 P53350 human CDCA5 113130 Q96FF9 CDCA5 human T115 469416 VPAtPtStPVPNPEA Sororin X -PLK1 PLK1 P53350 human BUB1B 701 O60566 BUB1B human T680 484623 IEDsREAtHSsGFSG X X -PLK1 PLK1 P53350 human MDM2 17246 P23804 Mdm2 mouse S258 454923 SLDsEDYsLSDEGHE X -PLK1 PLK1 P53350 human HSF1 3297 Q00613 HSF1 human S216 4668102 IPLMLNDsGsAHSMP X X -PLK1 PLK1 P53350 human MEK2 5605 P36507 MAP2K2 human S226 448074 LIDsMANsFVGtRSY Pkinase X 2338; 9121; 3958; 9154; 16211; 86128; 16780; 75262 -PLK1 PLK1 P53350 human PTEN 5728 P60484 PTEN human T383 448315 HyRYsDttDsDPENE X 9554; 9549; 7960 -PLK1 PLK1 P53350 human MST2 6788 Q13188 STK3 human S385 4274113 tMKRNAtsPQVQRPs X -PLK1 PLK1 P53350 human SRI 6717 P30626 SRI human T155 25754784 YstNGKItFDDYIAC X X -PLK1 PLK1 P53350 human NuaK1 9891 O60285 NUAK1 human S476 33406502 KKTQQREsGYYsSPE X -PLK1 PLK1 P53350 human STIL 6491 Q15468 STIL human S1116 17400758 LIsPNNMsFAtkKYM X X -PLK1 PLK1 P53350 human CLASP2 23122 O75122 CLASP2 human S1034 7990150 sIsPFNKsALKEAMF X X -PLK1 PLK1 P53350 human CDC27 996 P30260 CDC27 human T446 455863 EGkIStItPQIQAFN X -PLK1 PLK1 P53350 human MRE11A 4361 P49959 MRE11 human S649 455765 EVIEVDEsDVEEDIF X X -PLK1 PLK1 P53350 human Restin 6249 P30622 CLIP1 human S312 4769833 AsLKRsPsAssLsSM X X -PLK1 PLK1 P53350 human MST2 6788 Q13188 STK3 human S316 468210 LEEEEENsDEDELDs X X -PLK1 PLK1 P53350 human BUB1B 701 O60566 BUB1B human S676 767909 LsPIIEDsREAtHSs X -PLK1 PLK1 P53350 human APC1 64682 Q9H1A4 ANAPC1 human T701 455835 kkARPsEtGsDDDWE Apc1_MidN X -PLK1 PLK1 P53350 human APC1 64682 Q9H1A4 ANAPC1 human T530 455829 NtMPRPstPLDGVst X -PLK1 PLK1 P53350 human PTEN 5728 P60484 PTEN human T382 448314 DHyRYsDttDsDPEN X 9554; 9549; 7960 -PLK1 PLK1 P53350 human BORA 79866 Q6PGQ7 BORA human T501 2512943 QMDsGYNtQNCGSNI X -PLK1 PLK1 P53350 human CDC25B 994 P30305 CDC25B human T58 20503403 PVttLtQtMHDLAGL X -PLK1 PLK1 P53350 human TPT1 7178 P13693 TPT1 human S46 476067 tEGNIDDsLIGGNAs TCTP X X 5251 -PLK1 PLK1 P53350 human CDC25B 994 P30305 CDC25B human S209 20503405 PWkPTHPsSTHALAE M-inducer_phosp X -PLK1 PLK1 P53350 human FIRRM 55732 Q9NSG2 FIRRM human S43 31088424 SQARGLSsQNLEIQT X X -PLK1 PLK1 P53350 human Vimentin 22352 P20152 Vim mouse S459 470128 GQVINEtsQHHDDLE X -PLK1 PLK1 P53350 human JIP4 iso2 70834 Q58A65-2 Spag9 mouse T351 3952367 SGYKGSStPTKGIEN X -PLK1 PLK1 P53350 human ROCK2 282041 Q28021 ROCK2 cow S1099 1732202 QAQIAEEsQIRIELQ X -PLK1 PLK1 P53350 human NEDD1 121441 Q8NHV4 NEDD1 human S397 4272994 GkNQDFssFDDtGKs X -PLK1 PLK1 P53350 human SMAD4 4089 Q13485 SMAD4 human T197 1876808208 ASTETyStPALLAPS X -PLK1 PLK1 P53350 human RAD51 5888 Q06609 RAD51 human S14 23305001 LEANADtsVEEESFG X X -PLK1 PLK1 P53350 human MAD2L1BP 9587 Q15013 MAD2L1BP human S102 1245332 kHFyRkPsPQAEEML p31comet X -PLK1 PLK1 P53350 human ROCK2 282041 Q28021 ROCK2 cow S1374 468651 MKIQQNQsIRRPSRQ X -PLK1 PLK1 P53350 human Chk2 11200 O96017 CHEK2 human S210 12473000 DLtVDDQsVYPKALR X -PLK1 PLK1 P53350 human HBXAP 51773 Q96T23 RSF1 human S1359 3072999 ENVGKVGsPLDysLV X X -PLK1 PLK1 P53350 human CDC27 996 P30260 CDC27 human S426 455859 TQPNINDsLEItkLD X -PLK1 PLK1 P53350 human NEK9 91754 Q8TD19 NEK9 human T210 451116 SEYsMAEtLVGtPYY Pkinase X X -PLK1 PLK1 P53350 human IKKB 3551 O14920 IKBKB human S733 5014908 TVREQDQsFtALDWs IKKbetaNEMObind X -PLK1 PLK1 P53350 human Nlp 22981 Q9Y2I6 NINL human S686 451059 LEELHEKsQEVIWGL X -PLK1 PLK1 P53350 human ORC2 4999 Q13416 ORC2 human S188 21507302 SEYSASNsEDDEGVA X X -PLK1 PLK1 P53350 human Vimentin 7431 P08670 VIM human S56 451514 srsLyAssPGGVyAt Filament_head X X 3877; 7391 -PLK1 PLK1 P53350 human RASGRF1 192213 P28818 Rasgrf1 rat S781 18710205 GKTTLDTsKLCVASS X -PLK1 PLK1 P53350 human Survivin 332 O15392 BIRC5 human T21 14150104 LkDHRIstFkNWPFL BIR X -PLK1 PLK1 P53350 human PINX1 54984 Q96BK5 PINX1 human T317 14823404 EDATLEEtLVKKKKK X X -PLK1 PLK1 P53350 human RASGRF1 192213 P28818 Rasgrf1 rat S854 18710204 FPLFNYNsGIMMTCR X -CDK19 CDK19 Q9BWU1 human PAK1 5058 Q13153 PAK1 human S174 7320951 TPAVPPVsEDEDDDD X X -CDK19 CDK19 Q9BWU1 human eIF3-epsilon 8665 O00303 EIF3F human T119 7098400 GAARVIGtLLGTVDK JAB X X -CDK19 CDK19 Q9BWU1 human Notch 1 4851 P46531 NOTCH1 human S2513 35483201 EHPFLtPsPEsPDQW X X -CDK19 CDK19 Q9BWU1 human Notch 1 4851 P46531 NOTCH1 human T2511 483083 VPEHPFLtPsPEsPD X X -CDK19 CDK19 Q9BWU1 human eIF3-epsilon 8665 O00303 EIF3F human S46 448818 PAAAPASsSDPAAAA X X -CDK19 CDK19 Q9BWU1 human Notch 1 4851 P46531 NOTCH1 human S2516 35483202 FLtPsPEsPDQWsss X -Tssk3 TSSK3 Q9D2E1 mouse TSSK3 58864 Q9D2E1 Tssk3 mouse S166 458325 PKSRRELsQtFCGST Pkinase X -Ptk6 Brk Q64434 mouse EPS8 13860 Q08509 Eps8 mouse Y524 457963 NHQVDRNyDAVKTQP X X -Ptk6 Brk Q64434 mouse EPS8 13860 Q08509 Eps8 mouse Y534 63063500 VKTQPKKyAKSKYDF X X -Ptk6 Brk Q64434 mouse CTNNB1 1499 P35222 CTNNB1 human Y64 12170302 VDTsQVLyEWEQGFS X -Ptk6 Brk Q64434 mouse EPS8 13860 Q08509 Eps8 mouse Y497 450735 yAySSSMyHRGPHAD X X -MAK MAK P20794 human MAK 4117 P20794 MAK human T157 4715052 LRSQPPytDyVstRW Pkinase X X -MAK MAK P20794 human MAK 4117 P20794 MAK human Y159 462317 SQPPytDyVstRWYR Pkinase X X -Lck Lck P06240 mouse PKCD 170538 P09215 Prkcd rat Y311 447573 TPETVGIyQGFEKKT X 2055 -Lck Lck P06240 mouse ERK2 26413 P63085 Mapk1 mouse Y185 447594 HtGFLtEyVAtRWYR Pkinase X 9106; 4370; 4374; 9101; 4375; 4376; 4377; 3510; 5726; 88569; 13214; 13148; 70235; 9488; 89967; 8544; 14196; 14227; 14095; 14474; 75165; 98168; 33370; 54240; 15892; 45899; 55088; 9524; 69217; 48735 -Lck Lck P06240 mouse SHIP 16331 Q9ES52 Inpp5d mouse Y918 450030 NEMINPNyIGMGPFG X -Lck Lck P06240 mouse PECAM-1 18613 Q08481 Pecam1 mouse Y702 448760 TRATETVysEIRKVD X -Lck Lck P06240 mouse ZAP70 22637 P43404 Zap70 mouse Y318 447587 TSVyESPySDPEELK X 2701; 2717; 14791; 73382; 82975; 31754 -Lck Lck P06240 mouse Lck 16818 P06240 Lck mouse Y505 447823 FTATEGQyQPQP___ X 2751; 37458 -Lck Lck P06240 mouse CD3Z 12503 P24161 Cd247 mouse Y123 448934 KDKMAEAysEIGTKG ITAM X -Lck Lck P06240 mouse ITK 16428 Q03526 Itk mouse Y517 447997 RFVLDDQyTSSTGTK PK_Tyr_Ser-Thr X -Lck Lck P06240 mouse SHIP 16331 Q9ES52 Inpp5d mouse Y1021 448865 EMFENPLyGsVSSFP X 3941 -Lck Lck P06240 mouse LIME1 72699 Q9EQR5 Lime1 mouse Y261 463811 QGPLENVyESIKEMG LIME1 X -Lck Lck P06240 mouse CTLA-4 12477 P09793 Ctla4 mouse Y201 450897 SPLTTGVyVKMPPTE X X -Lck Lck P06240 mouse CD3Z 12503 P24161 Cd247 mouse Y72 448936 LQDPNQLyNELNLGR ITAM X -Lck Lck P06240 mouse LIME1 72699 Q9EQR5 Lime1 mouse Y242 454608 PLGSDVEyEAINLRG LIME1 X -Lck Lck P06240 mouse CD3Z 12503 P24161 Cd247 mouse Y142 448932 GKGHDGLyQGLsTAT ITAM X -Lck Lck P06240 mouse ZAP70 7535 P43403 ZAP70 human Y493 447505 LGADDsyytARsAGk PK_Tyr_Ser-Thr X X 2704 -Lck Lck P06240 mouse RIAM 54519 Q8R5A3 Apbb1ip mouse Y267 1871479100 FLEKEERyAVFKNPQ X -Lck Lck P06240 mouse ZAP70 22637 P43404 Zap70 mouse Y314 448867 MPMDTSVyESPySDP X -Lck Lck P06240 mouse CD3Z 12503 P24161 Cd247 mouse Y153 455204 sTATKDtyDALHMQT ITAM X -Lck Lck P06240 mouse PECAM-1 18613 Q08481 Pecam1 mouse Y679 448759 PQNMDVEyTEVEVSS X -Lck Lck P06240 mouse ZAP70 7535 P43403 ZAP70 human Y492 447504 ALGADDsyytARsAG PK_Tyr_Ser-Thr X X -Lck Lck P06240 mouse CD3Z 12503 P24161 Cd247 mouse Y83 449322 NLGRREEyDVLEKKR ITAM X -Lck Lck P06240 mouse DLG1 13383 Q811D0 Dlg1 mouse Y222 35530400 GTDADYEyEEITLER MAGUK_N_PEST X -Lck Lck P06240 mouse RIAM 54519 Q8R5A3 Apbb1ip mouse Y427 1871479101 AKYGKTLyDNYQRAV X -Lck Lck P06240 mouse ERK1 5595 P27361 MAPK3 human Y204 447543 HtGFLtEyVAtRWyr Pkinase X 9106; 4370; 4374; 9101; 4375; 4376; 4377; 3510; 5726; 88569; 13214; 13148; 70235; 9488; 89967; 8544; 14196; 14227; 14095; 14474; 75165; 98168; 33370; 54240; 15892; 45899; 55088; 9524; 69217; 48735 -Lck Lck P06240 mouse Lck 16818 P06240 Lck mouse Y394 447822 RLIEDNEytAREGAK PK_Tyr_Ser-Thr X 2101; 6943; 59548; 70926; 78740; 94361; 17320 -Lck Lck P06240 mouse CD3Z 12503 P24161 Cd247 mouse Y111 448933 RNPQEGVyNALQKDK ITAM X -Lck Lck P06240 mouse CTLA-4 12477 P09793 Ctla4 mouse Y218 450898 CEKQFQPyFIPIN__ X X -CDK5 CDK5 Q00535 human Tau iso8 4137 P10636-8 MAPT human T231 449079 KKVAVVRtPPKsPss X 20473; 71429 -CDK5 CDK5 Q00535 human MEF2D 81518 O89038 Mef2d rat S430 449407 SIKSEPVsPSRERSP X -CDK5 CDK5 Q00535 human STMN1 29332 P13668 Stmn1 rat S38 448556 SVPEFPLsPPKKkDL Stathmin X 3426; 4191 -CDK5 CDK5 Q00535 human PIK3C3 5289 Q8NEB9 PIK3C3 human T668 14662701 ENLDLkLtPYKVLAT X -CDK5 CDK5 Q00535 human BACE 23621 P56817 BACE1 human T252 48881800 YTGSLWYtPIRREWY Asp X X -CDK5 CDK5 Q00535 human Tau iso8 4137 P10636-8 MAPT human S199 447927 GDRsGyssPGsPGtP X 29957 -CDK5 CDK5 Q00535 human APP iso4 351 P05067-4 APP human T668 448523 VEVDAAVtPEERHLs APP_amyloid X -CDK5 CDK5 Q00535 human GJA1 14609 P23242 Gja1 mouse S282 448854 tAPLsPMsPPGykLV X -CDK5 CDK5 Q00535 human amphiphysin 273 P49418 AMPH human S285 455793 NHTLAPAsPAPARPR X -CDK5 CDK5 Q00535 human DRD2 1813 P14416 DRD2 human S321 31010702 GLHSTPDsPAkPEKN 7tm_1 X -CDK5 CDK5 Q00535 human 5-HT(6) 3362 P50406 HTR6 human S350 1867750504 ERQAsLAsPSLRTSH X -CDK5 CDK5 Q00535 human liprin alpha 1 233977 B2RXW8 Ppfia1 mouse T700 31873705 PPGsGRStPRRVPHs X -CDK5 CDK5 Q00535 human p70S6K 83840 P67999 Rps6kb1 rat S447 448357 GsPRtPVsPVKFsPG X 9204 -CDK5 CDK5 Q00535 human Lmr1 iso2 11302 Q80YE4-2 Aatk mouse S34 14364500 ADFSEQGsPAAAAQT X X -CDK5 CDK5 Q00535 human XDH 7498 P47989 XDH human T222 40560000 ELLRLKDtPRKQLRF X -CDK5 CDK5 Q00535 human FOXO1A 2308 Q12778 FOXO1 human S249 471071 EGGkSGksPrRrAAs X -CDK5 CDK5 Q00535 human PPP1CA 5499 P62136 PPP1CA human T320 448686 NPGGRPItPPRNsAK X 2581 -CDK5 CDK5 Q00535 human SEPT5 116728 Q9JJM9 Septin5 rat S327 454379 tQDSRMEsPIPILPL X -CDK5 CDK5 Q00535 human STMN3 50861 Q9NZ72 STMN3 human S68 454282 PSDLsPEsPMLssPP Stathmin X -CDK5 CDK5 Q00535 human STMN3 50861 Q9NZ72 STMN3 human S73 454283 PEsPMLssPPKKkDt Stathmin X -CDK5 CDK5 Q00535 human CTNND2 18163 O35927 Ctnnd2 mouse S357 4697626 IGTyATLsPtKRLVH X -CDK5 CDK5 Q00535 human CLIC4 29876 Q9QYB1 Clic4 mouse S108 4782152 PPkYLKLsPkHPESN X X -CDK5 CDK5 Q00535 human MEK2 26396 Q63932 Map2k2 mouse T395 452289 LRLKQPstPtRTAV_ X -CDK5 CDK5 Q00535 human DLC1 10395 Q96QB1 DLC1 human S642 37038504 DSFGSLPsPKELSSF X X -CDK5 CDK5 Q00535 human DBN1 1627 Q16643 DBN1 human S142 452446 NGLARLssPVLHRLR X X -CDK5 CDK5 Q00535 human CASK 12361 O70589 Cask mouse S51 1261103 DVAKFTssPGLsTED Pkinase X -CDK5 CDK5 Q00535 human Kv7.2 iso4 3785 O43526-4 KCNQ2 human S446 481668 ADQSLEDsPSKVPKS KCNQ_channel X -CDK5 CDK5 Q00535 human endophilin B1 54673 Q9JK48 Sh3glb1 mouse T145 26318403 TSALNFLtPLRNFIE BAR X X -CDK5 CDK5 Q00535 human Kv2.1 25736 P15387 Kcnb1 rat S655 473553 RsGFFVEsPRSSMKT Kv2channel X -CDK5 CDK5 Q00535 human Huntingtin 3064 P42858 HTT human S432 457592 AGGGssCsPVLsRKQ X X -CDK5 CDK5 Q00535 human RFA2 6118 P15927 RPA2 human S29 448338 QsPGGFGsPAPsQAE X -CDK5 CDK5 Q00535 human CRMP-2 iso3 1808 NP_001184222 DPYSL2 human S27 23053573 FKNLGsGsPKPRQKF X -CDK5 CDK5 Q00535 human FAK 5747 Q05397 PTK2 human S910 447964 KLQPQEIsPPPtANL X -CDK5 CDK5 Q00535 human Tau 17762 P10637 Mapt mouse T473 447932 kttPsPKtPPGsGEP X 12885; 66224; 62672 -CDK5 CDK5 Q00535 human AR 367 P10275 AR human S310 448413 TEDTAEysPFKGGYT Androgen_recep X X 61248 -CDK5 CDK5 Q00535 human kalirin 545156 A2CG49 Kalrn mouse T1572 3363402 EPIQLPKtPAKLRNN X X -CDK5 CDK5 Q00535 human CDK5R1 116671 P61810 Cdk5r1 rat T138 471393 PAITSAGtPKRVIVQ CDK5_activator X -CDK5 CDK5 Q00535 human CDK5R1 8851 Q15078 CDK5R1 human T138 471393 PAVTSAGtPKRVIVQ CDK5_activator X X -CDK5 CDK5 Q00535 human NDEL1 83431 Q9ERR1 Ndel1 mouse S231 474507 GTENSFPsPKAIPNG NUDE_C X -CDK5 CDK5 Q00535 human p70S6K iso2 6198 P23443-2 RPS6KB1 human S411 448356 SFEPKIRsPRRFIGs X -CDK5 CDK5 Q00535 human p53 7157 P04637 TP53 human S46 447536 AMDDLMLsPDDIEQW TAD2 X X 2521 -CDK5 CDK5 Q00535 human ESYT1 23943 Q3U7R1 Esyt1 mouse S314 15409842 QDVAQLRsPLPRGII X -CDK5 CDK5 Q00535 human PPAR-gamma 19016 P37238 Pparg mouse S273 15175800 TGkTTDKsPFVIYDM X X -CDK5 CDK5 Q00535 human WAVE1 Q5BJU7 Wasf1 rat S397 7979603 APPLVQPsPPVARAA X -CDK5 CDK5 Q00535 human RASGRF1 192213 P28818 Rasgrf1 rat S731 469604 PLAIGtssPVRRRKL RasGEF_N X -CDK5 CDK5 Q00535 human Tau iso8 4137 P10636-8 MAPT human S396 449081 GAEIVyKsPVVsGDt X 9632 -CDK5 CDK5 Q00535 human CLOCK 9575 O15516 CLOCK human T451 30259800 AVsDPSStPTKIPTD X X -CDK5 CDK5 Q00535 human SYN3 27204 Q8JZP2 Syn3 mouse S404 482763 VPGATVPsPLRPWGP X -CDK5 CDK5 Q00535 human CRMP-1 1400 Q14194 CRMP1 human T509 454314 PVyEVPAtPKyAtPA X X -CDK5 CDK5 Q00535 human Tau iso8 4137 P10636-8 MAPT human S404 449082 PVVsGDtsPRHLsNV X X 35834; 20194; 98523; 91600; 49562 -CDK5 CDK5 Q00535 human BRSK2 75770 Q69Z98 Brsk2 mouse S424 2085944 AssGLstsPLssPRV X -CDK5 CDK5 Q00535 human MEK2 26396 Q63932 Map2k2 mouse T397 483596 LKQPstPtRTAV___ X -CDK5 CDK5 Q00535 human KIF2A iso1 16563 P28740-1 Kif2a mouse T474 50269500 LGRNKPHtPFRAsKL Kinesin X -CDK5 CDK5 Q00535 human Tau iso8 4137 P10636-8 MAPT human S262 447930 NVKskIGstENLkHQ Tubulin-binding X -CDK5 CDK5 Q00535 human amphiphysin 273 P49418 AMPH human S272 455791 EEPsPLPsPTAsPNH X -CDK5 CDK5 Q00535 human PDE4B 18578 Q8VBU5 Pde4b mouse S130 468390 SDsDyDLsPKAMSRN X -CDK5 CDK5 Q00535 human nNOS 24598 P29476 Nos1 rat S293 56689901 QSPTKNGsPSRCPRF X -CDK5 CDK5 Q00535 human VRK3 51231 Q8IV63 VRK3 human S108 4762306 RPPtPKssPQKtRKs X X -CDK5 CDK5 Q00535 human HIF1A 3091 Q16665 HIF1A human S687 31876388 TEksHPRsPNVLsVA X X -CDK5 CDK5 Q00535 human TPPP 11076 O94811 TPPP human S18 456612 ANRtPPKsPGDPskD X -CDK5 CDK5 Q00535 human NFL 4747 P07196 NEFL human T21 2872004 ykRRYVEtPrVHISS Filament_head X -CDK5 CDK5 Q00535 human FZR1 51343 Q9UM11 FZR1 human S163 4661904 kSQKLLRsPRKPTRK X -CDK5 CDK5 Q00535 human MEK1 5604 Q02750 MAP2K1 human T292 448287 EtPPRPRtPGRPLss Pkinase X X 26975 -CDK5 CDK5 Q00535 human ADD2 119 P35612 ADD2 human S604 3147414 APAsPVQsPAKEAEt X -CDK5 CDK5 Q00535 human SYN1 281510 P17599 SYN1 cow S553 448377 TRPPAsPsPQRQAGP X -CDK5 CDK5 Q00535 human CTNND2 18163 O35927 Ctnnd2 mouse S300 14910701 rGssPKQsPsRLAKS X -CDK5 CDK5 Q00535 human HSP90A 3320 P07900 HSP90AA1 human S595 31909111 VsNRLVTsPCCIVts HSP90 X X -CDK5 CDK5 Q00535 human Kv-beta2 8514 Q13303 KCNAB2 human S31 3996100 IystrYGsPKRQLQF X -CDK5 CDK5 Q00535 human 5-HT(1A) 3350 P08908 HTR1A human T314 1867735500 LPSEAGPtPCAPASF 7tm_1 X -CDK5 CDK5 Q00535 human CRMP-2 iso3 1808 NP_001184222 DPYSL2 human S627 448082 PASsAKTsPAKQQAP X -CDK5 CDK5 Q00535 human JIP1 19099 Q9WVI9 Mapk8ip1 mouse T201 449954 PLKTGEQtPPHEHIC X -CDK5 CDK5 Q00535 human PARP1 142 P09874 PARP1 human S786 21440501 rGGsDDsskDPIDVN PARP_reg X -CDK5 CDK5 Q00535 human PRMT1 3276 Q99873 PRMT1 human Y309 454762 STsPEsPytHWkQtV X X -CDK5 CDK5 Q00535 human BRSK2 75770 Q69Z98 Brsk2 mouse S513 3572416 MSNLtPEssPELAKK X -CDK5 CDK5 Q00535 human MARCKS 396473 P16527 MARCKS chicken S26 455959 PGEAVAAsPSKANGQ MARCKS X -CDK5 CDK5 Q00535 human ADD1 118 P35611 ADD1 human T724 5246050 KKKKKFRtPsFLKKs X X -CDK5 CDK5 Q00535 human SEPT5 116728 Q9JJM9 Septin5 rat S161 2753800 HCCLYFIsPFGHGLR Septin X -CDK5 CDK5 Q00535 human NDEL1 83431 Q9ERR1 Ndel1 mouse S198 474508 TRKsAPssPtLDCEK NUDE_C X -CDK5 CDK5 Q00535 human PPAR-gamma 19016 P37238 Pparg mouse S112 448062 AIkVEPAsPPYYSEK X -CDK5 CDK5 Q00535 human Rb 5925 P06400 RB1 human S795 447979 sPykFPssPLrIPGG Rb_C X 9301 -CDK5 CDK5 Q00535 human XBP1 22433 O35426 Xbp1 mouse S61 21688102 RQRLTHLsPEEKALR bZIP_1 X X -CDK5 CDK5 Q00535 human NRF2 4780 Q16236 NFE2L2 human T395 40642203 VKQNGPKtPVHSSGD X -CDK5 CDK5 Q00535 human GJA1 14609 P23242 Gja1 mouse S279 448853 SsPtAPLsPMsPPGy X -CDK5 CDK5 Q00535 human Tau iso8 4137 P10636-8 MAPT human T153 449076 DGKtKIAtPRGAAPP X -CDK5 CDK5 Q00535 human p53 7157 P04637 TP53 human S33 447531 LPENNVLsPLPsQAM X 2526 -CDK5 CDK5 Q00535 human WAVE2 242687 Q8BH43 Wasf2 mouse S137 4258800 PPPLNNLsPYRDDGK X -CDK5 CDK5 Q00535 human DBN1 iso3 1627 Q16643-3 DBN1 human S142 452446 NGLARLSsPVLHRLR X X -CDK5 CDK5 Q00535 human Kv2.1 25736 P15387 Kcnb1 rat S607 473555 EATRFSHsPLASLsS Kv2channel X X -CDK5 CDK5 Q00535 human Doublecortin 1641 O43602 DCX human S28 451358 SRMNGLPsPtHSAHC X -CDK5 CDK5 Q00535 human CASK 12361 O70589 Cask mouse S395 1261102 DKINTkSsPQIRNPP L27 X -CDK5 CDK5 Q00535 human DIXDC1 330938 Q80Y83 Dixdc1 mouse S250 15714601 CSSLTSPsPIHSAKs X -CDK5 CDK5 Q00535 human SIRT2 64383 Q8VDQ8 Sirt2 mouse S368 482809 PNPsttIsPGksPPP X X -CDK5 CDK5 Q00535 human MST3 223255 Q99KH8 Stk24 mouse S79 33602703 TVLSQCDsPyVTKYY Pkinase X -CDK5 CDK5 Q00535 human CACNA1G 29717 O54898 Cacna1g rat S2234 15719444 DSTAASPsPKKDTLS X -CDK5 CDK5 Q00535 human STAT3 6774 P40763 STAT3 human S727 448191 NtIDLPMsPrTLDSL X X 9134; 9136; 34911; 94994; 49081; 58978; 87544; 71958; 50804 -CDK5 CDK5 Q00535 human PIP5K1C 23396 O60331 PIP5K1C human S650 457599 DERSWVysPLHYSAQ X X -CDK5 CDK5 Q00535 human PLA2G4A 5321 P47712 PLA2G4A human S505 447597 LNTSYPLsPLSDFAT PLA2_B X X 2831; 53044 -CDK5 CDK5 Q00535 human EFHD2 79180 Q96C19 EFHD2 human S74 478224 QGIGEPQsPsRRVFN X X -CDK5 CDK5 Q00535 human BRSK2 75770 Q69Z98 Brsk2 mouse T502 17554455 RRKLQVPtPEEMSNL X -CDK5 CDK5 Q00535 human MEF2A 4205 Q02078 MEF2A human S408 449949 SIkSEPIsPPRDRMT X X 9737 -CDK5 CDK5 Q00535 human DAB1 266729 Q8CJH2 Dab1 rat S491 479422 TPAPRQSsPSKSSAS X -CDK5 CDK5 Q00535 human CEND1 57754 Q9JKC6 Cend1 mouse S10 10285828 SRGKsAssPKPDtKV CEND1 X X -CDK5 CDK5 Q00535 human amphiphysin 273 P49418 AMPH human S276 455792 PLPsPTAsPNHTLAP X -CDK5 CDK5 Q00535 human p70S6K iso2 6198 P23443-2 RPS6KB1 human S429 471897 PVsPVKFsPGDFWGR X X -CDK5 CDK5 Q00535 human CRMP-1 25415 Q62950 Crmp1 rat T509 454314 PVyEVPAtPkHAaPA X -CDK5 CDK5 Q00535 human CDK5 1020 Q00535 CDK5 human S47 1255792403 DDEGVPssALREICL Pkinase X X -CDK5 CDK5 Q00535 human DLC1 10395 Q96QB1 DLC1 human S946 37038502 SVSPCPSsPKQIHLD X X -CDK5 CDK5 Q00535 human FZR1 51343 Q9UM11 FZR1 human T121 3827860 DRRLQPstPEKkGLF X -CDK5 CDK5 Q00535 human BRSK2 75770 Q69Z98 Brsk2 mouse S468 4734921 PNPtPPssPSVGGVP X -CDK5 CDK5 Q00535 human C9orf72 313155 Q66HC3 RGD1359108 rat S9 27720969 STICPPPsPAVAKTE X X -CDK5 CDK5 Q00535 human BRSK2 75770 Q69Z98 Brsk2 mouse S428 4734873 LstsPLssPRVtPHP X -CDK5 CDK5 Q00535 human eNOS 4846 P29474 NOS3 human S114 448638 RKLQGRPsPGPPAPE X X 9575 -CDK5 CDK5 Q00535 human DNMT1 1786 P26358 DNMT1 human S154 476108 AkPEPsPsPRITRkS X X -CDK5 CDK5 Q00535 human ATM 472 Q13315 ATM human S794 6413900 LSNCTKKsPNKIASG X X -CDK5 CDK5 Q00535 human PPP1R1A 58200 Q9ERT9 Ppp1r1a mouse S67 447758 LKSTLsMsPRQRKKM DARPP-32 X -CDK5 CDK5 Q00535 human Kv-beta2 29738 P62483 Kcnab2 rat S31 3996100 IyStRYGsPKRQLQF X X -CDK5 CDK5 Q00535 human PSEN1 5663 P49768 PSEN1 human T354 451669 HLGPHRstPEsRAAV Presenilin X X -CDK5 CDK5 Q00535 human BRSK2 75770 Q69Z98 Brsk2 mouse T432 17551645 PLssPRVtPHPsPRG X -CDK5 CDK5 Q00535 human BRSK2 75770 Q69Z98 Brsk2 mouse S514 3572419 SNLtPEssPELAKKs X -CDK5 CDK5 Q00535 human talin 1 7094 Q9Y490 TLN1 human S425 1984203 TMLEDsVsPKksTVL X X 5426; 13589 -CDK5 CDK5 Q00535 human CRMP-1 1400 Q14194 CRMP1 human S522 1295503 PAPsAKssPsKHQPP X -CDK5 CDK5 Q00535 human NRF2 4780 Q16236 NFE2L2 human S433 27461383 PEKELPVsPGHrktP X -CDK5 CDK5 Q00535 human FBXO22 26263 Q8NEZ5 FBXO22 human S162 1875332204 VTPMGsGsNRPQEIE X -CDK5 CDK5 Q00535 human DOR-1 24613 P33533 Oprd1 rat T161 455533 VKALDFRtPAKAKLI 7tm_1 X X -CDK5 CDK5 Q00535 human BRSK2 75770 Q69Z98 Brsk2 mouse T460 4734909 PKEsPAGtPNPtPPs X -CDK5 CDK5 Q00535 human CENTG1 iso2 116986 Q99490-2 AGAP2 human S249 478635 ACKSLPSsPSHSAAS X -CDK5 CDK5 Q00535 human Tau iso8 4137 P10636-8 MAPT human S409 449132 DtsPRHLsNVsstGs X -CDK5 CDK5 Q00535 human RASGRF2 19418 P70392 Rasgrf2 mouse S737 2902208 LAVSRTSsPVRARKL RasGEF_N X X -CDK5 CDK5 Q00535 human DRP1 114114 O35303 Dnm1l rat S585 25736596 RETKNVAsAGGGIGD X -CDK5 CDK5 Q00535 human ADD2 119 P35612 ADD2 human S617 3147402 EtKsPLVsPsKsLEE X -CDK5 CDK5 Q00535 human BRSK2 75770 Q69Z98 Brsk2 mouse T448 4734891 PLPtPKGtPVHtPKE X -CDK5 CDK5 Q00535 human GR 2908 P04150 NR3C1 human S226 451796 IDENCLLsPLAGEDD GCR X 97285 -CDK5 CDK5 Q00535 human PIK3C3 5289 Q8NEB9 PIK3C3 human T159 14659500 DGSEPTktPGRtssT PI3K_C2 X X -CDK5 CDK5 Q00535 human STXBP2 6813 Q15833 STXBP2 human T572 487544 IGSSHILtPTRFLDD Sec1 X -CDK5 CDK5 Q00535 human DBN1 iso3 1627 Q16643-3 DBN1 human S342 485840 SSSSSSSsPPRTPFP X X -CDK5 CDK5 Q00535 human Huntingtin 3064 P42858 HTT human S1179 465621 LtNPPsLsPIRRKGK X X -CDK5 CDK5 Q00535 human Kv2.1 25736 P15387 Kcnb1 rat S804 473562 ESsPLPTsPKFLRPN X -CDK5 CDK5 Q00535 human PIP5K1C 23396 O60331 PIP5K1C human S453 15721933 KNsSLKSsPSKKGrG X X -CDK5 CDK5 Q00535 human MCL1 4170 Q07820 MCL1 human T92 4825134 EVPDVTAtPARLLFF X -CDK5 CDK5 Q00535 human PXN 5829 P49023 PXN human S85 451054 HQQPQsssPVyGsSA Paxillin X -CDK5 CDK5 Q00535 human Huntingtin 3064 P42858 HTT human S1199 465620 EQAsVPLsPKKGSEA X X -CDK5 CDK5 Q00535 human GR 2908 P04150 NR3C1 human S203 447967 DLEFSSGsPGkEtNE GCR X X -CDK5 CDK5 Q00535 human CRMP-2 25416 P47942 Dpysl2 rat S522 448082 PASsAKTsPAKQQAP X X -CDK5 CDK5 Q00535 human Tau iso8 4137 P10636-8 MAPT human S202 447928 sGyssPGsPGtPGsR X X 39357; 30505 -CDK5 CDK5 Q00535 human APE1 11792 P28352 Apex1 mouse T232 14645304 NKkNAGFtPQERQGF Exo_endo_phos X -CDK5 CDK5 Q00535 human PKM 5315 P14618 PKM human S37 476070 MCRLDIDsPPItARN X -CDK5 CDK5 Q00535 human BRSK2 75770 Q69Z98 Brsk2 mouse T444 17551641 PRGsPLPtPKGtPVH X -CDK5 CDK5 Q00535 human EPRS 2058 P07814 EPRS1 human S886 452230 LsQssDssPtRNsEP X X -CDK5 CDK5 Q00535 human CDK5R1 8851 Q15078 CDK5R1 human S8 471392 MGTVLSLsPSYRKAT X X -CDK5 CDK5 Q00535 human DLC1 10395 Q96QB1 DLC1 human S557 37038503 LEEFDVFsPKQDLVP X X -CDK5 CDK5 Q00535 human RKIP 5037 P30086 PEBP1 human T42 3189667 DELGkVLtPTQVkNR PBP X X -CDK5 CDK5 Q00535 human girdin 55704 Q3V6T2 CCDC88A human S1675 454193 HHKIKtGsPGsEVVT X X -CDK5 CDK5 Q00535 human BIN1 274 O00499 BIN1 human T348 7532308 VPPPPKHtPSKEVKQ X -CDK5 CDK5 Q00535 human DAB1 iso2 13131 P97318-2 Dab1 mouse S491 479422 tPAPRQSsPSKSSAS X X -CDK5 CDK5 Q00535 human liprin alpha 1 8500 Q13136 PPFIA1 human T701 31873705 PPGsGRstPRRIPHs X X -CDK5 CDK5 Q00535 human KIF2A iso1 16563 P28740-1 Kif2a mouse S503 50269510 TCMIATIsPGMASCE Kinesin X -CDK5 CDK5 Q00535 human Lmr2 22853 Q8IWU2 LMTK2 human S1450 4957483 LQtsKyFsPPPPARS X -CDK5 CDK5 Q00535 human DDHD1 80821 Q8NEL9 DDHD1 human S11 22351356 PGrGsPRsPEHNGRG X -CDK5 CDK5 Q00535 human CDK5R1 116671 P61810 Cdk5r1 rat S8 471392 MGTVLSLsPSYRKAT X -CDK5 CDK5 Q00535 human Kv2.1 25736 P15387 Kcnb1 rat S520 473565 EKARSSssPQHLNVQ Kv2channel X -CDK5 CDK5 Q00535 human CRMP-1 12933 P97427 Crmp1 mouse T509 454314 PVyEVPAtPkHAAPA X -CDK5 CDK5 Q00535 human WAVE2 313024 Q5FWU0 Wasf2 rat S137 4258800 PPPLNNLsPYRDDGK X -CDK5 CDK5 Q00535 human NOXA 5366 Q13794 PMAIP1 human S13 17790900 ARKNAQPsPARAPAE PMAIP1 X X 41967 -CDK5 CDK5 Q00535 human PPAR-gamma 19016 P37238 Pparg mouse T296 38507800 KIKFkHItPLQEQSK X -CDK5 CDK5 Q00535 human TRIM59 286827 Q8IWR1 TRIM59 human S308 50801655 LIPKMKIsPkRMSCS X X -CDK5 CDK5 Q00535 human PPP1R1A 58977 P19103 Ppp1r1a rat S67 447758 LKSTLsMsPRQRKKM DARPP-32 X -CDK5 CDK5 Q00535 human p70S6K 83840 P67999 Rps6kb1 rat S434 448356 SFEPKIRsPRRFIGs X X -CDK5 CDK5 Q00535 human Tau iso8 4137 P10636-8 MAPT human T217 449078 sRtPsLPtPPtREPK X 33134; 51625 -CDK5 CDK5 Q00535 human DDHD1 80821 Q8NEL9 DDHD1 human S727 465585 TIPsPVtsPVLSRRH DDHD X -CDK5 CDK5 Q00535 human FZR1 51343 Q9UM11 FZR1 human S40 3215931 PAssPVssPsKHGDR X -CDK5 CDK5 Q00535 human WAVE1 Q5BJU7 Wasf1 rat S441 7979602 PPGIRPSsPVTVAAL X -CDK5 CDK5 Q00535 human Src 6714 P12931 SRC human S75 450326 NssDtVtsPQRAGPL X -CDK5 CDK5 Q00535 human Tau iso8 4137 P10636-8 MAPT human S214 447929 GsRsRtPsLPtPPtR X 77348 -CDK5 CDK5 Q00535 human PLD2 5338 O14939 PLD2 human S134 456492 ARFAVAYsPARDAGN PX X -CDK5 CDK5 Q00535 human TPPP 11076 O94811 TPPP human S160 487536 GVtKAIssPtVSRLT p25-alpha X -CDK5 CDK5 Q00535 human PPAR-gamma 5468 P37231 PPARG human S273 15175800 TGktTDKsPFVIYDM X -CDK5 CDK5 Q00535 human WAVE1 Q5BJU7 Wasf1 rat S310 4764996 LIENRPQsPAAGRTP X -CDK5 CDK5 Q00535 human DLC1 10395 Q96QB1 DLC1 human S859 37038505 RRENsSDsPKELKRR X X -CDK5 CDK5 Q00535 human BRSK2 75770 Q69Z98 Brsk2 mouse T452 4734897 PKGtPVHtPKEsPAG X -CDK5 CDK5 Q00535 human TRPC6 7225 Q9Y210 TRPC6 human S14 4959823 FGPRrGssPrGAAGA X X -CDK5 CDK5 Q00535 human NUDE1 iso1 54820 Q9NXR1-1 NDE1 human T191 20722719 QKQEKPRtPMPSSVE NUDE_C X -CDK5 CDK5 Q00535 human TPPP 11076 O94811 TPPP human T14 456614 PAKAANRtPPKsPGD X -CDK5 CDK5 Q00535 human DAB1 iso2 13131 P97318-2 Dab1 mouse S400 479417 TNDSARSsPQSDKPR X X -CDK5 CDK5 Q00535 human CENTG1 iso2 116986 Q99490-2 AGAP2 human S279 478561 YSSSLPSsPNVGHRE X X -CDK5 CDK5 Q00535 human RFA2 6118 P15927 RPA2 human S33 448339 GFGsPAPsQAEkkSR X 10148 -CDK5 CDK5 Q00535 human ODFP1 24610 P21769 Odf1 rat S193 2859801 SPCYPCTsPCNPCNP X -CDK5 CDK5 Q00535 human SNTB2 20650 Q61235 Sntb2 mouse S75 471147 NRGLGPPsPPAPPRG X -CDK5 CDK5 Q00535 human p53 7157 P04637 TP53 human S20 447529 PLsQEtFsDLWkLLP P53_TAD X 9287 -CDK5 CDK5 Q00535 human ADD2 119 P35612 ADD2 human S701 1983442 PEGsPsKsPsKKKKK X -CDK5 CDK5 Q00535 human RFA2 6118 P15927 RPA2 human S23 448337 GAGGYtQsPGGFGsP X -CDK5 CDK5 Q00535 human BRSK2 75770 Q69Z98 Brsk2 mouse T510 3572413 PEEMSNLtPEssPEL X -CDK5 CDK5 Q00535 human Tau iso8 4137 P10636-8 MAPT human T181 447932 ktPPAPktPPssGEP X X 12885; 66224; 62672 -CDK5 CDK5 Q00535 human BRSK2 75770 Q69Z98 Brsk2 mouse T464 4734913 PAGtPNPtPPssPSV X -CDK5 CDK5 Q00535 human DARPP-32 19049 Q60829 Ppp1r1b mouse T75 448048 RPNPCAYtPPSLKAV DARPP-32 X 2301 -CDK5 CDK5 Q00535 human DRP1 10059 O00429 DNM1L human S616 454690 PIPIMPAsPQKGHAV X 3455; 4494; 63940 -CDK5 CDK5 Q00535 human SDS3 71954 Q8BR65 Suds3 mouse S228 454398 RTLNKLKsPKRPAsP Sds3 X X -CDK5 CDK5 Q00535 human STMN1 29332 P13668 Stmn1 rat S25 448555 QAFELILsPRSKESV Stathmin X -CDK5 CDK5 Q00535 human CLOCK 9575 O15516 CLOCK human T461 469131 KIPTDTstPPRQHLP X X -CDK5 CDK5 Q00535 human HuR 1994 Q15717 ELAVL1 human S202 3197192 LLsQLyHsPArrFGG X X -CDK5 CDK5 Q00535 human BAG3 9531 O95817 BAG3 human S291 467532 stPLHsPsPIRVHTV X -CDK5 CDK5 Q00535 human MEF2D 4209 Q14814 MEF2D human S444 449407 SIkSEPVsPsRERsP X -CDK5 CDK5 Q00535 human BRSK2 75770 Q69Z98 Brsk2 mouse S490 2085948 IKNSFLGsPRFHRRK X -CDK5 CDK5 Q00535 human PHACTR3 116154 Q96KR7 PHACTR3 human S318 18944907 QGRESKGsPKKRLDV X -CDK5 CDK5 Q00535 human Myc 4609 P01106 MYC human S77 448586 LLPtPPLsPsRRsGL Myc_N X 13748 -CDK5 CDK5 Q00535 human BRSK2 75770 Q69Z98 Brsk2 mouse S456 4734903 PVHtPKEsPAGtPNP X -CDK5 CDK5 Q00535 human CRMP-4 1809 Q14195 DPYSL3 human S522 458800 PAGsArGsPtRPNPP X -CDK5 CDK5 Q00535 human CACNA1B 257648 Q02294 Cacna1b rat S2016 25792205 TQPAPNAsPMKRSIS X -CDK5 CDK5 Q00535 human PARK2 5071 O60260 PRKN human S131 454421 HTDsRkDsPPAGsPA X X -CDK5 CDK5 Q00535 human CDK16 18555 Q04735 Cdk16 mouse S95 453454 tssDEVQsPVRVRMR X -CDK5 CDK5 Q00535 human PLA2G4A 5321 P47712 PLA2G4A human T268 3190702 HNPLLLLtPQkVkRY PLA2_B X X -CDK5 CDK5 Q00535 human CRMP-2 1808 Q16555 DPYSL2 human S522 448082 PAssAktsPAkQQAP X X -CDK5 CDK5 Q00535 human APE1 328 P27695 APEX1 human T233 14645304 NKkNAGFtPQERQGF Exo_endo_phos X -CDK5 CDK5 Q00535 human PKAR2B 24679 P12369 Prkar2b rat T69 10941783 GAAAGGGtPsKGVNF X -CDK5 CDK5 Q00535 human KCNMA1 374065 Q8AYS8 KCNMA1 chicken T871 4715376 QANSQGFtPPGMDRS X -CDK5 CDK5 Q00535 human Tau iso8 4137 P10636-8 MAPT human T212 447934 tPGsRsRtPsLPtPP X -CDK5 CDK5 Q00535 human SIRT2 64383 Q8VDQ8 Sirt2 mouse S372 482810 ttIsPGksPPPAKEA X X -CDK5 CDK5 Q00535 human AR 367 P10275 AR human S83 448714 QQQQQETsPRQQQQQ Androgen_recep X -CDK5 CDK5 Q00535 human Huntingtin 29424 P51111 Htt rat S1150 465621 LTNPPSLsPIRRKGK X -CDK5 CDK5 Q00535 human KIF13B 305967 Q70AM4 Kif13b rat T506 27145806 PEGQVMLtPQKNTRT FHA X -CDK5 CDK5 Q00535 human PARP1 142 P09874 PARP1 human S782 3180399 ySLLrGGsDDsskDP PARP_reg X -CDK5 CDK5 Q00535 human DAB1 266729 Q8CJH2 Dab1 rat S400 479417 TNDSARSsPQSDKPR X -CDK5 CDK5 Q00535 human BRSK2 75770 Q69Z98 Brsk2 mouse S440 4734885 PHPsPRGsPLPtPKG X -CDK5 CDK5 Q00535 human VEGFR2 3791 P35968 KDR human S229 56790201 RIYDVVLsPSHGIEL Ig_3 X -CDK5 CDK5 Q00535 human PPP1R1A 58977 P19103 Ppp1r1a rat S6 478275 __MEPDNsPRKIQFT DARPP-32 X -CDK5 CDK5 Q00535 human SIPA1L1 217692 Q8C0T5 Sipa1l1 mouse S1328 3595500 sLGAstssPRSGPGK X -CDK5 CDK5 Q00535 human CTNNB1 1499 P35222 CTNNB1 human S246 469995 ALVKMLGsPVDSVLF Arm X -CDK5 CDK5 Q00535 human AMFR 267 Q9UKV5 AMFR human S516 3148446 sIRPALNsPVERPss X X -CDK5 CDK5 Q00535 human NDEL1 83431 Q9ERR1 Ndel1 mouse T219 468252 ASLsLPAtPVGKGTE NUDE_C X -CDK5 CDK5 Q00535 human DYN1 1759 Q05193 DNM1 human T780 452368 RsPtssPtPQRRAPA X -CDK5 CDK5 Q00535 human FOXO1A 56458 Q9R1E0 Foxo1 mouse S246 471071 EGGkSGksPRRRAAs X -CDK5 CDK5 Q00535 human p70S6K iso2 6198 P23443-2 RPS6KB1 human S424 448357 GsPRtPVsPVKFsPG X X -CDK5 CDK5 Q00535 human PPP1R1A 58200 Q9ERT9 Ppp1r1a mouse S6 478275 __MEPDNsPRKIQFT DARPP-32 X -CDK5 CDK5 Q00535 human PXN iso2 5829 P49023-2 PXN human S244 465487 VNQGEMSsPQRVtst Paxillin X X -CDK5 CDK5 Q00535 human ACSS2 55902 Q9NR19 ACSS2 human S267 460828 MGDstsQsPPIkRSC AMP-binding X X -CDK5 CDK5 Q00535 human NRF2 4780 Q16236 NFE2L2 human T439 40642202 VsPGHrktPFTkDkH X -CDK5 CDK5 Q00535 human FBXO22 26263 Q8NEZ5 FBXO22 human S160 1875332202 IVVTPMGsGsNRPQE X -CDK5 CDK5 Q00535 human p53 7157 P04637 TP53 human S15 447490 PsVEPPLsQEtFsDL P53_TAD X 4030; 9235; 9284; 9286; 8695; 8514; 82530; 56979 -CDK5 CDK5 Q00535 human Rb 5925 P06400 RB1 human S807 447980 PGGNIyIsPLksPyk Rb_C X 9308; 8974; 4277; 40283; 8957; 8516; 11917; 99274; 41359; 75864; 72443 -CDK5 CDK5 Q00535 human DRP1 114114 O35303 Dnm1l rat S635 454690 PIPIMPAsPQKGHAV X 3455; 4494; 63940 -CDK5 CDK5 Q00535 human PPP1R2 5504 P41236 PPP1R2 human T73 449051 MKIDEPstPyHSMMG IPP-2 X -CDK5 CDK5 Q00535 human PRNP 5621 P04156 PRNP human S43 10273948 SRyPGQGsPGGNRYP X -CDK5 CDK5 Q00535 human HTRA2 27429 O43464 HTRA2 human S400 487467 IHkVILGsPAHRAGL PDZ_6; Peptidase_M50 X X -CDK5 CDK5 Q00535 human SIPA1L1 246212 O35412 Sipa1l1 rat S1367 3595500 SLGASTSsPRSGPGK X -CDK5 CDK5 Q00535 human Huntingtin 29424 P51111 Htt rat S1170 465620 EQTSTPMsPKKGGEA X -CDK5 CDK5 Q00535 human Tau iso8 4137 P10636-8 MAPT human T205 447933 ssPGsPGtPGsRsRt X X 25377; 43964; 53001; 49561; 20060; 33032; 30505; 20739; 98160 -CDK5 CDK5 Q00535 human HDAC5 10014 Q9UQL6 HDAC5 human S279 4788487 KVAERRssPLLRRKD X X -CDK5 CDK5 Q00535 human LRRK2 120892 Q5S007 LRRK2 human S1627 54400802 KHPKGIIsRRDVEKF COR X X -CDK5 CDK5 Q00535 human axin 1 8312 O15169 AXIN1 human T481 451091 HVQRVLRtPGRQsPG Axin_b-cat_bind X -CDK5 CDK5 Q00535 human Kv7.2 iso4 3785 O43526-4 KCNQ2 human S427 15721018 VAAKGKGsPQAQTVR X -CDK5 CDK5 Q00535 human CTNNB1 1499 P35222 CTNNB1 human S191 467710 sRHAIMRsPQMVsAI X -CDK5 CDK5 Q00535 human lamin A/C 4000 P02545 LMNA human S392 452606 ErLRLsPsPtsQRsR X -CDK5 CDK5 Q00535 human Tau iso8 4137 P10636-8 MAPT human S422 449083 GsIDMVDsPQLAtLA X -CDK5 CDK5 Q00535 human TPX2 22974 Q9ULW0 TPX2 human S486 455699 LPItVPksPAFALkN TPX2_importin X X -CDK5 CDK5 Q00535 human Rb 5925 P06400 RB1 human S811 448717 IyIsPLksPykIsEG Rb_C X 9308; 8974; 4277; 40283; 8957; 8516; 11917; 41359; 75864; 63276 -CDK5 CDK5 Q00535 human PARP1 142 P09874 PARP1 human S785 21440500 LrGGsDDsskDPIDV PARP_reg X -CDK5 CDK5 Q00535 human DYN1 140694 P21575 Dnm1 rat S778 450206 GRRsPTSsPTPQRRA X X -CDK5 CDK5 Q00535 human SEPT5 iso2 5413 Q99719-2 SEPTIN5 human S17 475075 RLVEQLLsPRTQAQr X X -CDK5 CDK5 Q00535 human USF2 7392 Q15853 USF2 human S155 36392500 NPFSNGGsPAAEAVS X X -CDK5 CDK5 Q00535 human Tau iso8 4137 P10636-8 MAPT human S235 449080 VVRtPPKsPssAKsR X X 20473 -CDK5 CDK5 Q00535 human Kv-beta2 29738 P62483 Kcnab2 rat S9 486012 YPESTTGsPARLSLR X X -CDK5 CDK5 Q00535 human NFAT5 10725 O94916 NFAT5 human T135 469161 tVQQHPstPkRHtVL X X -CDK5 CDK5 Q00535 human CLASP2 23122 O75122 CLASP2 human S541 24976300 REssRDTsPVRSFQP X -CDK5 CDK5 Q00535 human EPRS 2058 P07814 EPRS1 human S999 9720900 NQGGGLsssGAGEGQ X -CDK5 CDK5 Q00535 human BRSK2 75770 Q69Z98 Brsk2 mouse S436 4734879 PRVtPHPsPRGsPLP X -CDK5 CDK5 Q00535 human gephyrin 64845 Q03555 Gphn rat S283 2020113 LSttPsEsPRAQAts X X -CDK5 CDK5 Q00535 human BAG3 29810 Q9JLV1 Bag3 mouse S297 467532 GtPVHCPsPIRVHTV X -CDK5 CDK5 Q00535 human SAPAP1 65040 P97836 Dlgap1 rat S77 9418959 FPRRHyTsQQELKDE X -CDK5 CDK5 Q00535 human USF2 7392 Q15853 USF2 human S222 9285181 APRTHPysPkIDGtR X X -CDK5 CDK5 Q00535 human TRPV1 193034 Q704Y3 Trpv1 mouse T407 473576 IAYSSSEtPNRHDML X -CDK5 CDK5 Q00535 human GR 2908 P04150 NR3C1 human S211 447968 PGkEtNEsPWRSDLL GCR X X 4161 -CDK5 CDK5 Q00535 human Vimentin 7431 P08670 VIM human S56 451514 srsLyAssPGGVyAt Filament_head X 3877; 7391 -CDK5 CDK5 Q00535 human BRSK2 75770 Q69Z98 Brsk2 mouse S467 4734917 tPNPtPPssPSVGGV X -CDK5 CDK5 Q00535 human VACAMKL 235604 Q3UHL1 Camkv mouse T345 60179300 QSASDAAtPGAAGGA X -CDK5 CDK5 Q00535 human TH 21823 P24529 Th mouse S31 448544 KQAEAVtsPRFIGRR TOH_N X 3370; 13041 -Dapk1 DAPK1 Q80YE7 mouse MRLC2 67938 Q3THE2 Myl12b mouse S20 448595 KRPQRAtsNVFAMFD X X -Dapk1 DAPK1 Q80YE7 mouse MRLC2 67938 Q3THE2 Myl12b mouse T19 448596 KKRPQRAtsNVFAMF X X -Dapk1 DAPK1 Q80YE7 mouse DAPK1 69635 Q80YE7 Dapk1 mouse S308 448142 ARKKWKQsVRLISLC X -Dapk1 DAPK1 Q80YE7 mouse MRLC2 103910 O14950 MYL12B human S20 448595 KRPQRAtsNVFAMFD X -Dapk1 DAPK1 Q80YE7 mouse NMDAR2B 14812 Q01097 Grin2b mouse S1303 450171 NKLRRQHsyDtFVDL NMDAR2_C X X 20274; 71335 -Ptk2b Pyk2 Q9QVP9 mouse IKKB 16150 O88351 Ikbkb mouse Y188 449632 sFVGTLQyLAPELLE Pkinase X X -Ptk2b Pyk2 Q9QVP9 mouse TBK1 56480 Q9WUN2 Tbk1 mouse Y179 23151249 sLYGTEEyLHPDMYE Pkinase X X -Ptk2b Pyk2 Q9QVP9 mouse DDEF1 13196 Q9QWY8 Asap1 mouse Y308 450437 PKEVGGLyVASRANS X X -Ptk2b Pyk2 Q9QVP9 mouse PXN 19303 Q8VI36 Pxn mouse Y31 448785 FLsEEPPysyPTGNH X -Ptk2b Pyk2 Q9QVP9 mouse IKKB 16150 O88351 Ikbkb mouse Y199 449633 ELLEQQKyTVTVDYW Pkinase X X -Ptk2b Pyk2 Q9QVP9 mouse Pyk2 19229 Q9QVP9 Ptk2b mouse Y402 447955 CSIESDIyAEIPDET X X 3291 -Camk1d CAMK1D iso2 Q8BW96-2 mouse CAMK1D iso2 227541 Q8BW96-2 Camk1d mouse S349 7101531 SFLLRRGsQESELRG X X -NME2 NME2 P22392 human NME2 4831 P22392 NME2 human H118 474519 QVGrNIIhGsDsVkS NDK X -NME2 NME2 P22392 human G-beta 1 2782 P62873 GNB1 human H266 9643001 QELMTYShDNIICGI WD40 X -NME2 NME2 P22392 human KCNN4 3783 O15554 KCNN4 human H358 474525 FRQVRLKhRKLREQV CaMBD X X -PNCK CAMK1B Q6P2M8 human HSP90A 3320 P07900 HSP90AA1 human S391 18495100 FIrGVVDsEDLPLNI HSP90 X X -PNCK CAMK1B Q6P2M8 human EIF4G3 8672 O43432 EIF4G3 human S1156 2915400 NTFMRGGssKDLLDN X X -PNCK CAMK1B Q6P2M8 human HSP90B 3326 P08238 HSP90AB1 human T89 18495101 RtLtLVDtGIGMtkA HATPase_c X X -PNCK CAMK1B Q6P2M8 human HSP90A 3320 P07900 HSP90AA1 human T624 8149779 QALRDNstMGyMAAk HSP90 X X -Mapk1 ERK2 P63086 rat p90RSK 6195 Q15418 RPS6KA1 human T573 447993 AENGLLMtPCytANF Pkinase X 9346 -Mapk1 ERK2 P63086 rat GJA1 24392 P08050 Gja1 rat S282 448854 TAPLsPMsPPGYkLV X -Mapk1 ERK2 P63086 rat vinexin 282843 Q8CJ75 Sorbs3 rat S593 452554 DSPQLPTsPHLTTTA X -Mapk1 ERK2 P63086 rat CASP9 842 P55211 CASP9 human T125 449563 PEVLRPEtPRPVDIG X -Mapk1 ERK2 P63086 rat ERK2 26413 P63085 Mapk1 mouse Y185 447594 HtGFLtEyVAtRWYR Pkinase X 9106; 4370; 4374; 9101; 4375; 4376; 4377; 3510; 5726; 88569; 13214; 13148; 70235; 9488; 89967; 8544; 14196; 14227; 14095; 14474; 75165; 98168; 33370; 54240; 15892; 45899; 55088; 9524; 69217; 48735 -Mapk1 ERK2 P63086 rat GR 24413 P06536 Nr3c1 rat S246 451796 LIDENLLsPLAGEDD GCR X 97285 -Mapk1 ERK2 P63086 rat TRPV2 29465 Q9WUD2 Trpv2 rat S6 29631548 __MTSASsPPAFRLE X -Mapk1 ERK2 P63086 rat TRPV2 29465 Q9WUD2 Trpv2 rat S47 12738661 QREDRNSsPQIKVNL X -Mapk1 ERK2 P63086 rat AML1 861 Q01196 RUNX1 human S266 454400 QYLGsIAsPsVHPAt X X -Mapk1 ERK2 P63086 rat Fos 314322 P12841 Fos rat T331 448484 CtPVVTCtPSCTTYT X -Mapk1 ERK2 P63086 rat SYN1 24949 P09951 Syn1 rat S62 451572 stAAPVAsPAAPsPG X -Mapk1 ERK2 P63086 rat ERK2 116590 P63086 Mapk1 rat T183 447593 HDHtGFLtEyVAtRW Pkinase X 9106; 4370; 4374; 9101; 4375; 4376; 4377; 3510; 5726; 88569; 13214; 13148; 70235; 9488; 89967; 8544; 14196; 14227; 14095; 14474; 75165; 98168; 33370; 54240; 15892; 45899; 55088; 9524; 69217; 48735 -Mapk1 ERK2 P63086 rat DUSP6 116663 Q64346 Dusp6 rat S197 455266 SATDSDGsPLSNSQP X -Mapk1 ERK2 P63086 rat SYN1 24949 P09951 Syn1 rat S549 451574 PAARPPAsPsPQRQA X -Mapk1 ERK2 P63086 rat LIFR 3977 P42702 LIFR human S1044 450385 WNLVsPDsPRsIDSN X -Mapk1 ERK2 P63086 rat PTP-SL iso2 19279 Q62132-2 Ptprr mouse T253 450119 EPFVAVStPREKVAM X -Mapk1 ERK2 P63086 rat ARG3.1 54323 Q63053 Arc rat S206 149319101 PGEDGQPsPGVDTQI X -Mapk1 ERK2 P63086 rat Fos 314322 P12841 Fos rat S374 448482 PSSDSLSsPTLLAL_ X -Mapk1 ERK2 P63086 rat GJA1 24392 P08050 Gja1 rat S279 448853 SSPTAPLsPMsPPGY X -Mapk1 ERK2 P63086 rat SP1 6667 P08047 SP1 human T739 448227 sEGSGtAtPSALITT X -Mapk1 ERK2 P63086 rat ERK2 116590 P63086 Mapk1 rat T188 3949250 FLtEyVAtRWYRAPE Pkinase X -Mapk1 ERK2 P63086 rat TH 25085 P04177 Th rat S8 448543 MPTPSAPsPQPKGFR TOH_N X -Mapk1 ERK2 P63086 rat ENaC-gamma 24768 P37091 Scnn1g rat T623 451220 PGSTVPGtPPPRYNT X -Mapk1 ERK2 P63086 rat SYN1 24949 P09951 Syn1 rat S67 451573 VAsPAAPsPGSSGGG X -Mapk1 ERK2 P63086 rat UBF 25574 P25977 Ubtf rat T117 448504 DFPKKPLtPYFRFFM HMG_box X X -Mapk1 ERK2 P63086 rat ARG3.1 54323 Q63053 Arc rat T368 149319103 QAAEPSVtPLPTEDE X -Mapk1 ERK2 P63086 rat Bcl-3 602 P20749 BCL3 human S122 143278600 CPMEHPLsADIAMAT X -Mapk1 ERK2 P63086 rat TRPV2 29465 Q9WUD2 Trpv2 rat S37 8110156 QEPPPMEsPFQREDR X -Mapk1 ERK2 P63086 rat AML1 861 Q01196 RUNX1 human S249 454399 DTRQIQPsPPWsyDQ X X 4327 -Mapk1 ERK2 P63086 rat SMAD3 4088 P84022 SMAD3 human S208 451179 DAGsPNLsPNPMsPA X -Mapk1 ERK2 P63086 rat PDE4D iso6 24627 P14270-6 Pde4d rat S585 451090 YQSTIPQsPSPAPDD X -Mapk1 ERK2 P63086 rat ENaC-beta 24767 P37090 Scnn1b rat T613 451219 QTLPIPGtPPPNYDS X -Mapk1 ERK2 P63086 rat ERK2 116590 P63086 Mapk1 rat Y185 447594 HtGFLtEyVAtRWYR Pkinase X 9106; 4370; 4374; 9101; 4375; 4376; 4377; 3510; 5726; 88569; 13214; 13148; 70235; 9488; 89967; 8544; 14196; 14227; 14095; 14474; 75165; 98168; 33370; 54240; 15892; 45899; 55088; 9524; 69217; 48735 -Mapk1 ERK2 P63086 rat JunD 24518 P52909 Jund rat S100 456168 LGLLKLAsPELERLI Jun X 9164 -Mapk1 ERK2 P63086 rat GR 24413 P06536 Nr3c1 rat T171 451795 TSATGCAtPTEKEFP GCR X -Mapk1 ERK2 P63086 rat PAK1 29431 P35465 Pak1 rat T211 448176 VIEPLPVtPTRDVAT X X -Mapk1 ERK2 P63086 rat Myc 4609 P01106 MYC human S77 448586 LLPtPPLsPsRRsGL Myc_N X 13748 -Mapk1 ERK2 P63086 rat GATA4 54254 P46152 Gata4 rat S105 449604 AYTPPPVsPRFSFPG GATA-N X -Mapk1 ERK2 P63086 rat SP1 6667 P08047 SP1 human T453 448226 SGPIIIRtPTVGPNG X -Mapk1 ERK2 P63086 rat EFNB3 360546 G3V7D4-1 Efnb3 rat S332 27722391 VQDGPPQsPPNIYYK X -Mapk1 ERK2 P63086 rat TRPV2 29465 Q9WUD2 Trpv2 rat S760 7103644 LPLQVLQsP______ X -Mapk1 ERK2 P63086 rat UBF 25574 P25977 Ubtf rat T201 448505 DIPEKPKtPQQLWYT HMG_box X X -Mapk1 ERK2 P63086 rat TH 25085 P04177 Th rat S31 448544 KQAEAVtsPRFIGRR TOH_N X X 3370; 13041 -Mapk1 ERK2 P63086 rat GRASP65 56082 O35254 Gorasp1 rat S277 455582 EQLPGPGsPGHGTAD X -Mapk1 ERK2 P63086 rat ARG3.1 54323 Q63053 Arc rat T380 149319102 EDETEALtPALTSES X -PRKD2 PRKD2 Q9BZL6 human IFNAR1 3454 P17181 IFNAR1 human S535 454418 SSQTsQDsGNysNED X X -PRKD2 PRKD2 Q9BZL6 human PAK4 10298 O96013 PAK4 human S99 2192540 MsVTRsNsLRRDsPP X X -PRKD2 PRKD2 Q9BZL6 human PIK4CB iso2 5298 Q9UBF8-2 PI4KB human S294 457621 SNLKRtAsNPKVENE X X -PRKD2 PRKD2 Q9BZL6 human Cortactin 2017 Q14247 CTTN human S298 5014901 EKLAkHEsQQDyskG HS1_rep X -PRKD2 PRKD2 Q9BZL6 human SET iso2 6418 Q01105-2 SET human S171 27425001 KDLTKRSsQTQNKAs NAP X X -PRKD2 PRKD2 Q9BZL6 human arfaptin 1 iso2 27236 P53367-2 ARFIP1 human S100 3191827 LELVRKWsLNTYKCT Arfaptin X X -PRKD2 PRKD2 Q9BZL6 human ITGB4 iso2 3691 P16144-2 ITGB4 human T1736 1243302 EFVSRTLttSGTLST X -PRKD2 PRKD2 Q9BZL6 human MFF 56947 Q9GZY8 MFF human S172 484865 GQLVRNDsLWHRsDs Miff X -PRKD2 PRKD2 Q9BZL6 human CIB1 10519 Q99828 CIB1 human S78 479918 ERICRVFsTSPAKDS X X -PRKD2 PRKD2 Q9BZL6 human VASP 7408 P50552 VASP human S239 448380 GAKLRKVsKQEEASG X 3114; 37565 -PRKD2 PRKD2 Q9BZL6 human HDAC7 51564 Q8WUI4 HDAC7 human S181 470131 NPLLRKEsAPPsLRR X -PRKD2 PRKD2 Q9BZL6 human SSH1 54434 Q8WYL5 SSH1 human S978 455275 sPLKRSHsLAKLGSL X -PRKD2 PRKD2 Q9BZL6 human HDAC5 10014 Q9UQL6 HDAC5 human S498 447996 RPLSRtQsSPLPQsP X 3424 -PRKD2 PRKD2 Q9BZL6 human PKD2 5311 Q13563 PKD2 human S801 15702202 SSLPRPMsSRSFPRs X -PRKD2 PRKD2 Q9BZL6 human MARK2 2011 Q7KZI7 MARK2 human S400 5635600 HkVQRsVsANPKQRR X -PRKD2 PRKD2 Q9BZL6 human PRKD2 25865 Q9BZL6 PRKD2 human S876 448800 QGLAERIsVL_____ X -PRKD2 PRKD2 Q9BZL6 human Rin1 9610 Q13671 RIN1 human S292 4949757 QLLRREssVGyRVPA X -PRKD2 PRKD2 Q9BZL6 human SSH1 54434 Q8WYL5 SSH1 human S937 455274 SNLtRssssDsIHsV X -PRKD2 PRKD2 Q9BZL6 human VASP 7408 P50552 VASP human S157 448379 EHIERRVsNAGGPPA X 3111; 84519 -PRKD2 PRKD2 Q9BZL6 human VASP 7408 P50552 VASP human S322 469024 TtLPRMkssssVttS X -CAMK2B CAMK2B Q13554 human GSK3B 84027 P18266 Gsk3b rat S9 449111 SGRPRTTsFAESCKP X 9336; 9331; 9327; 9323; 9322; 9325; 5558; 8566; 79774; 8466; 25462; 14026; 14332; 14310; 14630 -CAMK2B CAMK2B Q13554 human SAPAP1 iso2 9229 O14490-2 DLGAP1 human S393 4775408 RRFTRSNsVTTAVQA GKAP X -CAMK2B CAMK2B Q13554 human SAPAP1 iso2 9229 O14490-2 DLGAP1 human S349 2049913 FKKNRCLsIGIQVDD GKAP X -CAMK2B CAMK2B Q13554 human CAMK2B 12323 P28652 Camk2b mouse T311 15719513 ILttMLAtRNFsVGR X X -CAMK2B CAMK2B Q13554 human CAMK2B 12323 P28652 Camk2b mouse T307 2020797 LkGAILttMLAtRNF X X -CAMK2B CAMK2B Q13554 human AMPKA1 5562 Q13131 PRKAA1 human T183 448786 sDGEFLRtsCGsPNy Pkinase X 2535; 2531; 4188; 5256; 50081; 74281 -CAMK2B CAMK2B Q13554 human ITGB1 3688 P05556 ITGB1 human T789 447709 IyksAVttVVNPkyE Integrin_b_cyt X -CAMK2B CAMK2B Q13554 human STMN1 3925 P16949 STMN1 human S16 448554 kELEKrAsGQAFELI Stathmin X 3353 -CAMK2B CAMK2B Q13554 human FAM134B 54463 Q9H6L5 RETREG1 human S151 2509195 AQLWRSLsESWEVIN Reticulon X X -CAMK2B CAMK2B Q13554 human GABBR1 81657 Q9Z0U4 Gabbr1 rat S898 15167000 ITRGEWQsETQDtMK X -CAMK2B CAMK2B Q13554 human CAMK2B 12323 P28652 Camk2b mouse S26 455245 DIGkGAFsVVRRCVk Pkinase X X -CAMK2B CAMK2B Q13554 human CAMK2B 12323 P28652 Camk2b mouse S182 18007574 AGtPGYLsPEVLRKE Pkinase X -CAMK2B CAMK2B Q13554 human CAMK2B 12323 P28652 Camk2b mouse T306 451706 kLkGAILttMLAtRN X X -CAMK2B CAMK2B Q13554 human ITGB1 3688 P05556 ITGB1 human T788 448600 PIyksAVttVVNPky Integrin_b_cyt X -CAMK2B CAMK2B Q13554 human occludin 100506658 Q16625 OCLN human S471 6094301 LDDyREEsEEyMAAA Occludin_ELL X -CAMK2B CAMK2B Q13554 human CAMK2B 12323 P28652 Camk2b mouse T287 450048 sMMHRQEtVECLKKF X X 12716 -CAMK2B CAMK2B Q13554 human CAMK2G 818 Q13555 CAMK2G human T287 467596 sMMHRQEtVECLRKF X 12716 -CAMK2B CAMK2B Q13554 human CAMK2B 816 Q13554 CAMK2B human T287 450048 sMMHRQEtVECLKKF X 12716 -CAMK2B CAMK2B Q13554 human GSK3A 50686 P18265 Gsk3a rat S21 448584 SGRARtssFAEPGGG X 9337; 9316; 9331; 9327; 8452; 8566 -PAK5 PAK5 Q9P286 human DDX5 1655 P17844 DDX5 human T69 1875793000 HPDLARRtAQEVETY X X -PAK5 PAK5 Q9P286 human PAK5 57144 Q9P286 PAK5 human S573 11327000 HRDIKSDsILLTSDG Pkinase X -PAK5 PAK5 Q9P286 human syntaphilin iso2 9751 O15079-2 SNPH human S59 50800758 SRRTsAGsRRRtsPP X -PAK5 PAK5 Q9P286 human E2A 6929 P15923 TCF3 human S39 15500103 NGkGRPAsLAGAQFG X X -PAK5 PAK5 Q9P286 human syntaphilin iso2 9751 O15079-2 SNPH human S64 481340 AGsRRRtsPPVSVRD Syntaphilin X -PAK5 PAK5 Q9P286 human DNPEP iso2 23549 Q9ULA0-2 DNPEP human S109 34733463 VKRRSRRsQVGFQQV Peptidase_M18 X X -PAK5 PAK5 Q9P286 human GATA1 2623 P15976 GATA1 human S161 40407600 SSLPVPNsAYGGPDF X X -PAK5 PAK5 Q9P286 human SRSF11 9295 Q05519 SRSF11 human S287 470248 KSRSRRRsKsPRRRR X X -PAK5 PAK5 Q9P286 human syntaphilin iso2 9751 O15079-2 SNPH human S56 23150247 LPGSRRTsAGsRRRt X -PAK5 PAK5 Q9P286 human GATA1 2623 P15976 GATA1 human S187 451237 LNSAAYSsPKLRGTL X -PAK5 PAK5 Q9P286 human PDCD8 9131 O95831 AIFM1 human T281 1872824900 GAEVksRtTLFRKIG Pyr_redox_2 X -PAK5 PAK5 Q9P286 human syntaphilin iso2 9751 O15079-2 SNPH human T63 23150253 sAGsRRRtsPPVSVR Syntaphilin X -Wnk1 WNK1 Q9JIH7 rat WNK4 287715 Q7TPK6 Wnk4 rat S332 456207 KRASFAKsVIGTPEF Pkinase X -Wnk1 WNK1 Q9JIH7 rat WNK1 116477 Q9JIH7 Wnk1 rat S378 456474 LATLKRAsFAKsVIG Pkinase X -Wnk1 WNK1 Q9JIH7 rat WNK1 116477 Q9JIH7 Wnk1 rat S382 454105 KRAsFAKsVIGTPEF Pkinase X -Wnk1 WNK1 Q9JIH7 rat SYT2 20980 P46097 Syt2 mouse T202 454031 ETKVHRKtLNPAFNE C2 X X -Wnk1 WNK1 Q9JIH7 rat SYT2 20980 P46097 Syt2 mouse T386 454032 VGSNATGtELRHWSD C2 X -DCLK1 DCAMKL1 O15075 human IKKB 16150 O88351 Ikbkb mouse S181 447489 DQGsLCTsFVGTLQy Pkinase X X 2697; 2694; 14938; 92255; 36516; 36214 -DCLK1 DCAMKL1 O15075 human CCAR1 55749 Q8IX12 CCAR1 human S343 470613 RKRsRERsPRRERER X -DCLK1 DCAMKL1 O15075 human IKKB 16150 O88351 Ikbkb mouse S177 447492 AKELDQGsLCTsFVG Pkinase X X 2078; 2697; 2694; 14938; 92255; 36516; 36214 -ACVR1B ALK4 P36896 human TTRAP 51567 O95551 TDP2 human T88 12563300 PkTyVDLtNEEtTDs X -ACVR1B ALK4 P36896 human TTRAP 51567 O95551 TDP2 human T92 12563301 VDLtNEEtTDsTTSK X -CASK CASK O14936 human CASK 8573 O14936 CASK human S151 2506803 PHCVLLAsKENsAPV Pkinase X -CASK CASK O14936 human NRXN1 iso1 9378 P58400-1 NRXN1 human S425 2506806 VKEKQPssAKsSNKN Syndecan X -CASK CASK O14936 human NRXN1 iso1 9378 P58400-1 NRXN1 human S424 2506807 VVKEKQPssAKsSNK Syndecan X -CASK CASK O14936 human CASK 8573 O14936 CASK human S155 2506804 LLAsKENsAPVKLGG Pkinase X -CASK CASK O14936 human NRXN1 iso1 9378 P58400-1 NRXN1 human S428 2506805 KQPssAKsSNKNKKN Syndecan X -FGFR3 FGFR3 P22607 human FGFR3 2261 P22607 FGFR3 human Y724 448116 ANCTHDLyMIMRECW PK_Tyr_Ser-Thr X -FGFR3 FGFR3 P22607 human CTNNB1 1499 P35222 CTNNB1 human Y142 449044 AVVNLINyQDDAELA X X -FGFR3 FGFR3 P22607 human PTEN 5728 P60484 PTEN human Y240 448316 RREDKFMyFEFPQPL PTEN_C2 X -FGFR3 FGFR3 P22607 human FGFR3 2261 P22607 FGFR3 human Y648 463337 DVHNLDyyKKTTNGR PK_Tyr_Ser-Thr X -FGFR3 FGFR3 P22607 human FGFR3 2261 P22607 FGFR3 human Y647 463336 RDVHNLDyyKKTTNG PK_Tyr_Ser-Thr X -FGFR3 FGFR3 P22607 human GLO1 2739 Q04760 GLO1 human Y136 463450 GIAVPDVysACkRFE Glyoxalase X -FGFR3 FGFR3 P22607 human TET2 54790 Q6N021 TET2 human Y1902 1870773107 TRISLVFyQHKSMNE Tet_JBP X -FGFR3 FGFR3 P22607 human RSK2 6197 P51812 RPS6KA3 human Y529 464205 TITKTVEyLHAQGVV Pkinase X X -FGFR3 FGFR3 P22607 human ICK 22858 Q9UPZ9 CILK1 human Y15 35479600 RQLGDGtyGsVLLGR Pkinase X -FGFR3 FGFR3 P22607 human RSK2 6197 P51812 RPS6KA3 human Y488 464203 DVyDDGKyVYVVTEL Pkinase X -FGFR3 FGFR3 P22607 human STAT1 6772 P42224 STAT1 human Y701 447754 DGPkGtGyIktELIs X 9174; 9167; 5375; 25685; 8062; 8183; 8009; 55603; 7649; 25809; 57216; 45118; 39205; 88845; 88211; 76285; 90145 -TLK2 TLK2 Q86UE8 human ASF1B 55723 Q9NVP2 ASF1B human S198 7997068 PGLLPENsMDCI___ X -TLK2 TLK2 Q86UE8 human ASF1A 25842 Q9Y294 ASF1A human S192 12671900 GWSTSENsLNVMLES X -MAP2K6 MKK6 P52564 human P38G 6300 P53778 MAPK12 human Y185 448032 ADsEMtGyVVTRWYR Pkinase X 9211; 9215; 4551; 9216; 4552; 4631; 4511; 4092; 9219; 24678; 8632; 6908; 41768; 51255; 14594; 14598; 62979 -MAP2K6 MKK6 P52564 human P38D 26415 Q9Z1B7 Mapk13 mouse Y182 454935 TDTEMtGyVVTRWYR Pkinase X 9211; 9215; 4551; 9216; 4552; 4631; 4511; 4092; 9219; 24678; 8632; 6908; 41768; 51255; 14594; 14598; 62979 -MAP2K6 MKK6 P52564 human HSF4 3299 Q9ULV5 HSF4 human T471 30318200 LGLPGALtIYSTPES X -MAP2K6 MKK6 P52564 human P38A 26416 P47811 Mapk14 mouse T180 447970 RHtDDEMtGyVAtRW Pkinase X X 9211; 9215; 4551; 9216; 4552; 4631; 4511; 4092; 9219; 24678; 8632; 6908; 41768; 51255; 14594; 14598; 62979 -MAP2K6 MKK6 P52564 human P38G 6300 P53778 MAPK12 human T183 448031 RQADsEMtGyVVTRW Pkinase X 9211; 9215; 4551; 9216; 4552; 4631; 4511; 4092; 9219; 24678; 8632; 6908; 41768; 51255; 14594; 14598; 62979 -MAP2K6 MKK6 P52564 human PAK6 56924 Q9NQU5 PAK6 human Y566 454426 KsLVGtPyWMAPEVI Pkinase X -MAP2K6 MKK6 P52564 human P38A 81649 P70618 Mapk14 rat T180 447970 RHTDDEMtGyVATRW Pkinase X 9211; 9215; 4551; 9216; 4552; 4631; 4511; 4092; 9219; 24678; 8632; 6908; 41768; 51255; 14594; 14598; 62979 -MAP2K6 MKK6 P52564 human P38A 81649 P70618 Mapk14 rat Y182 447971 TDDEMtGyVATRWYR Pkinase X 9211; 9215; 4551; 9216; 4552; 4631; 4511; 4092; 9219; 24678; 8632; 6908; 41768; 51255; 14594; 14598; 62979 -MAP2K6 MKK6 P52564 human P38D 5603 O15264 MAPK13 human T180 4787496 RHADAEMtGyVVtRW Pkinase X 9211; 9215; 4551; 9216; 4552; 4631; 4511; 4092; 9219; 24678; 8632; 6908; 41768; 51255; 14594; 14598; 62979 -MAP2K6 MKK6 P52564 human MKK6 5608 P52564 MAP2K6 human S207 448194 IsGyLVDsVAKtIDA Pkinase X 9231; 12280 -MAP2K6 MKK6 P52564 human MKK6 5608 P52564 MAP2K6 human Y219 1186001 IDAGCKPyMAPERIN Pkinase X -MAP2K6 MKK6 P52564 human P38A 1432 Q16539 MAPK14 human T180 447970 RHtDDEMtGyVAtRW Pkinase X X 9211; 9215; 4551; 9216; 4552; 4631; 4511; 4092; 9219; 24678; 8632; 6908; 41768; 51255; 14594; 14598; 62979 -MAP2K6 MKK6 P52564 human P38A 26416 P47811 Mapk14 mouse Y182 447971 tDDEMtGyVAtRWYR Pkinase X X 9211; 9215; 4551; 9216; 4552; 4631; 4511; 4092; 9219; 24678; 8632; 6908; 41768; 51255; 14594; 14598; 62979 -MAP2K6 MKK6 P52564 human P38D 26415 Q9Z1B7 Mapk13 mouse T180 4787496 RHTDTEMtGyVVTRW Pkinase X 9211; 9215; 4551; 9216; 4552; 4631; 4511; 4092; 9219; 24678; 8632; 6908; 41768; 51255; 14594; 14598; 62979 -MAP2K6 MKK6 P52564 human P38D 5603 O15264 MAPK13 human Y182 454935 ADAEMtGyVVtRWYR Pkinase X 9211; 9215; 4551; 9216; 4552; 4631; 4511; 4092; 9219; 24678; 8632; 6908; 41768; 51255; 14594; 14598; 62979 -MAP2K6 MKK6 P52564 human P38A 1432 Q16539 MAPK14 human Y182 447971 tDDEMtGyVAtRWYR Pkinase X X 9211; 9215; 4551; 9216; 4552; 4631; 4511; 4092; 9219; 24678; 8632; 6908; 41768; 51255; 14594; 14598; 62979 -Csk CSK P41241 mouse PECAM-1 18613 Q08481 Pecam1 mouse Y702 448760 TRATETVysEIRKVD X -Csk CSK P41241 mouse Lck 16818 P06240 Lck mouse Y505 447823 FTATEGQyQPQP___ X X 2751; 37458 -Csk CSK P41241 mouse LYN 17096 P25911 Lyn mouse Y508 447624 YtATEGQyQQQP___ X 2731 -Csk CSK P41241 mouse PECAM-1 18613 Q08481 Pecam1 mouse Y679 448759 PQNMDVEyTEVEVSS X -Csk CSK P41241 mouse Fyn 2534 P06241 FYN human Y531 447883 FtAtEPQyQPGENL_ X -Camkk1 CAMKK1 Q8VBY2 mouse CAMK1A 52163 Q91YS8 Camk1 mouse T177 448527 DPGSVLstACGtPGY Pkinase X -Camkk1 CAMKK1 Q8VBY2 mouse CAMK1D 227541 Q8BW96 Camk1d mouse T180 450469 GKGDVMstACGtPGY Pkinase X -Prkcb PKCB P68404 mouse PKCB 18751 P68404 Prkcb mouse S661 448672 QNEFAGFsyTNPEFV Pkinase_C X 9371 -Prkcb PKCB P68404 mouse TFEB 21425 Q9R210 Tfeb mouse S462 4785132 PEASKAssRRssFsM DUF3371 X -Prkcb PKCB P68404 mouse OSBPL9 114883 Q96SU4 OSBPL9 human S287 476780 PNTVPEFsYSSsEDE X X -Prkcb PKCB P68404 mouse PKCB 18751 P68404 Prkcb mouse T500 447896 WDGVttKtFCGtPDy Pkinase X 9379; 2060; 38938 -Prkcb PKCB P68404 mouse TNNI3 21954 P48787 Tnni3 mouse S24 448424 APVRRRssANyRAYA Troponin-I_N X -Prkcb PKCB P68404 mouse TFEB 21425 Q9R210 Tfeb mouse S461 4785127 sPEASKAssRRssFs DUF3371 X -Prkcb PKCB P68404 mouse PKCA 18750 P20444 Prkca mouse T497 448598 MDGVttRtFCGtPDy Pkinase X 9379; 2060; 38938 -Prkcb PKCB P68404 mouse Btk 12229 P35991 Btk mouse S180 447577 GsLKPGssHRKTKKP X 3537 -Prkcb PKCB P68404 mouse TNNI3 21954 P48787 Tnni3 mouse S23 448423 PAPVRRRssANyRAY Troponin-I_N X -Prkcb PKCB P68404 mouse GLRB 14658 P48168 Glrb mouse S425 2048205 NDFSIVGsLPRDFEL Neur_chan_memb X -Prkcb PKCB P68404 mouse Akt1 11651 P31750 Akt1 mouse S473 447855 RPHFPQFsysAsGtA Pkinase_C X 9271; 3787; 4060; 4051; 5102; 4058; 2336; 2337; 4075; 4070; 5012; 4071; 92982; 5315; 9563; 9018; 12694; 52240; 11962; 15116; 88106; 26580; 68035; 31957; 23430; 20235 -Prkcb PKCB P68404 mouse PKCB iso2 18751 P68404-2 Prkcb mouse S660 1869073011 QsEFEGFsFVNsEFL Pkinase_C X -Prkcb PKCB P68404 mouse GSK3A 50686 P18265 Gsk3a rat S21 448584 SGRARtssFAEPGGG X 9337; 9316; 9331; 9327; 8452; 8566 -Prkcb PKCB P68404 mouse occludin 18260 Q61146 Ocln mouse S489 6094300 RLKQVKGsADYKSKR Occludin_ELL X -EIF2AK4 GCN2 Q9P2K8 human GCN2 440275 Q9P2K8 EIF2AK4 human T899 455461 SDPSGHLtGMVGTAL Pkinase X 94668 -EIF2AK4 GCN2 Q9P2K8 human MARS 4141 P56192 MARS1 human S229 22496702 EEELATLsEEEIAMA X -EIF2AK4 GCN2 Q9P2K8 human MARS 4141 P56192 MARS1 human S472 22496703 LGRTLPGsDWTPNAQ tRNA-synt_1g X -EIF2AK4 GCN2 Q9P2K8 human MARS 4141 P56192 MARS1 human S662 22496701 NRAGMFVskFFGGYV X X -EIF2AK4 GCN2 Q9P2K8 human eIF2-alpha 13665 Q6ZWX6 Eif2s1 mouse S52 447635 MILLSELsRrrIRSI S1 X X 3597; 9721; 3398; 5199; 53085; 95797 -EIF2AK4 GCN2 Q9P2K8 human eIF2-alpha 1965 P05198 EIF2S1 human S52 447635 MILLsELsRRRIRsI S1 X 3597; 9721; 3398; 5199; 53085; 95797 -Sgk1 SGK1 Q9WVC6 mouse NEDD4L 23327 Q96PU5 NEDD4L human S342 453438 ssRLRsCsVtDAVAE X 12146 -Sgk1 SGK1 Q9WVC6 mouse SHANK2 iso7 171093 Q9QX74-7 Shank2 rat S477 33668500 GPRSRSPsLNRLGGA X -Sgk1 SGK1 Q9WVC6 mouse NLRP3 216799 Q8R4B8 Nlrp3 mouse S3 38492201 _____MTsVRCKLAQ X -Sgk1 SGK1 Q9WVC6 mouse iNOS 18126 P29477 Nos2 mouse S903 455638 ILKPRYYsISSSQDH FAD_binding_1 X -Sgk1 SGK1 Q9WVC6 mouse iNOS 18126 P29477 Nos2 mouse S733 455637 VFTMRLKsQQNLQSE FAD_binding_1 X -Sgk1 SGK1 Q9WVC6 mouse NEDD4L 23327 Q96PU5 NEDD4L human S448 453440 IRRPRsLssPtVtLS X 8063 -Sgk1 SGK1 Q9WVC6 mouse ROMK 56379 O88335 Kcnj1 mouse S25 449605 RQRARLVsKDGRCNI IRK X X -Sgk1 SGK1 Q9WVC6 mouse CREB 1385 P16220 CREB1 human S119 448228 EILsRRPsyRkILND pKID X 9187; 9196; 9198; 4095; 14228; 14001; 39561; 80120; 44864; 54960; 95995 -Sgk1 SGK1 Q9WVC6 mouse NEDD4L 23327 Q96PU5 NEDD4L human T367 453439 AGRARsstVtGGEEP X -Sgk1 SGK1 Q9WVC6 mouse TRPV4 59341 Q9HBA0 TRPV4 human S824 4777181 LRRDRWssVVPRVVE X -Sgk1 SGK1 Q9WVC6 mouse MKK4 26398 P47809 Map2k4 mouse S78 447655 IERLRTHsIESsGKL X 9155 -Sgk1 SGK1 Q9WVC6 mouse NDRG1 17988 Q62433 Ndrg1 mouse T346 454245 GtRsRsHtsEGPRsR X 3217; 5482; 6992; 7497; 8947; 89166 -FLT4 VEGFR3 P35916 human GLO1 2739 Q04760 GLO1 human Y136 463450 GIAVPDVysACkRFE Glyoxalase X X -MATK CTK P42679 human SHPS1 140885 P78324 SIRPA human Y453 1861200 EPNNHTEyASIQTSP X -MATK CTK P42679 human SHPS1 140885 P78324 SIRPA human Y429 458557 QDTNDItyADLNLPk X -MATK CTK P42679 human LYN 4067 P07948 LYN human Y508 447624 ytAtEGQyQQQP___ X 2731 -Epha2 EphA2 Q03145 mouse NLRP3 216799 Q8R4B8 Nlrp3 mouse Y132 1869022700 ICKKKKDyCKMYRRH X -Csnk2b CK2B P67871 mouse OLIG2 50913 Q9EQW6 Olig2 mouse S13 18357900 SLVSsRPssPEPDDL X -Pkn1 PKN1 P70268 mouse rabphilin 3A 19894 P47708 Rph3a mouse S271 455801 AGLRRANsVQAARPA X -Pkn1 PKN1 P70268 mouse CRYAB 12955 P23927 Cryab mouse S45 448748 FSTATSLsPFYLRPP Crystallin X -Pkn1 PKN1 P70268 mouse TRAF1 22029 P39428 Traf1 mouse S139 26331402 MALERNLsELQLQAA X -Pkn1 PKN1 P70268 mouse CRYAB 12955 P23927 Cryab mouse S59 448783 PSFLRAPsWIDtGLS X -Pkn1 PKN1 P70268 mouse rabphilin 3A 19894 P47708 Rph3a mouse S234 455904 GPPTRRAsEARMSTA X -VRK2 VRK2 Q86Y07 human coilin 8161 P38432 COIL human S184 11329300 NEEAKRKsPKKKEKC Coilin_N X -VRK2 VRK2 Q86Y07 human GAPDH 2597 P04406 GAPDH human S151 3178959 LkIIsNAsCttNCLA X -VRK2 VRK2 Q86Y07 human USP25 29761 Q9UHP3 USP25 human T680 27533602 QPLVGIEtLPPDLRD X -VRK2 VRK2 Q86Y07 human USP25 29761 Q9UHP3 USP25 human S745 40407602 PEyLEQPsRSDFSKH X -VRK2 VRK2 Q86Y07 human TKT 7086 P29401 TKT human T287 452283 skkkILAtPPQEDAP X -VRK2 VRK2 Q86Y07 human BAF 8815 O75531 BANF1 human S4 458302 ____MttsQkHRDFV BAF X -VRK2 VRK2 Q86Y07 human DTNBP1 84062 Q96EV8 DTNBP1 human S299 40721501 RAKPPsSssTCtDSA Dysbindin X X -VRK2 VRK2 Q86Y07 human BAF 8815 O75531 BANF1 human T3 7105313 _____MttsQkHRDF BAF X -VRK2 VRK2 Q86Y07 human PLK1 5347 P53350 PLK1 human T210 448139 YDGERKktLCGtPNy Pkinase X X 4354; 5472; 9062 -VRK2 VRK2 Q86Y07 human p53 22059 P02340 Tp53 mouse T21 447541 ELPLsQEtFsGLWKL P53_TAD X -VRK2 VRK2 Q86Y07 human USP25 29761 Q9UHP3 USP25 human T727 40407603 QkLRESEtSVTTAQA X -VRK2 VRK2 Q86Y07 human IKKB 3551 O14920 IKBKB human S177 447492 AkELDQGsLCtsFVG Pkinase X X 2078; 2697; 2694; 14938; 92255; 36516; 36214 -VRK2 VRK2 Q86Y07 human BAF 8815 O75531 BANF1 human T2 7105310 ______MttsQkHRD BAF X -VRK2 VRK2 Q86Y07 human IKKB 3551 O14920 IKBKB human S181 447489 DQGsLCtsFVGTLQy Pkinase X X 2697; 2694; 14938; 92255; 36516; 36214 -VRK2 VRK2 Q86Y07 human DTNBP1 84062 Q96EV8 DTNBP1 human S297 9320776 ELRAKPPsSssTCtD Dysbindin X X -Mapk10 JNK3 P49187 rat STMN2 84510 P21818 Stmn2 rat S62 450174 ELILKPPsPISEAPR Stathmin X -Mapk10 JNK3 P49187 rat STMN2 84510 P21818 Stmn2 rat S73 450173 EAPRTLAsPKKkDLs Stathmin X -PFKP PFKP Q01813 human ATG4B 23192 Q9Y4P1 ATG4B human S34 4750282 WILGRKYsIFTEkDE X -ROCK1 ROCK1 Q13464 human eNOS 4846 P29474 NOS3 human T495 447885 TGITRKKtFKEVANA X 9574 -ROCK1 ROCK1 Q13464 human Radixin 5962 P35241 RDX human T564 448374 AGRDKyKtLRQIRQG ERM_C X 3141; 3726; 32600 -ROCK1 ROCK1 Q13464 human TSC2 24855 P49816 Tsc2 rat T1203 19075303 EILVRRPtGNTSWLM X -ROCK1 ROCK1 Q13464 human NHE1 6548 P19634 SLC9A1 human T653 4729330 LRsYNRHtLVADPyE NEXCaM_BD X -ROCK1 ROCK1 Q13464 human GRF-1 2909 Q9NRY4 ARHGAP35 human T1173 3213723 GRFASYRtsFsVGsD RhoGAP_pG1_pG2 X -ROCK1 ROCK1 Q13464 human FHOD1 29109 Q9Y613 FHOD1 human S1137 2035403 RsRGNRKsLRRtLKs X X -ROCK1 ROCK1 Q13464 human ARHGAP24 83478 Q8N264 ARHGAP24 human S391 484901 RsSMNNGsPtALSGs X -ROCK1 ROCK1 Q13464 human FHOD1 29109 Q9Y613 FHOD1 human T1141 2035402 NRKsLRRtLKsGLGD X X -ROCK1 ROCK1 Q13464 human Ezrin 7430 P15311 EZR human T567 448104 QGRDkyKtLRQIRQG ERM_C X X 3141; 3726; 32600 -ROCK1 ROCK1 Q13464 human GFAP 2670 P14136 GFAP human S38 449621 LGPGTRLsLARMPPP Filament_head X X -ROCK1 ROCK1 Q13464 human PTEN 5728 P60484 PTEN human S229 456213 VkIYSsNsGPtRRED PTEN_C2 X X -ROCK1 ROCK1 Q13464 human GRF-1 2909 Q9NRY4 ARHGAP35 human S1236 7159801 PKPKPRPsITKATWE RhoGAP_pG1_pG2 X -ROCK1 ROCK1 Q13464 human Vimentin 22352 P20152 Vim mouse S72 449026 ssAVRLRssVPGVRL Filament_head X -ROCK1 ROCK1 Q13464 human desmin 1674 P17661 DES human T17 449613 RVssYRRtFGGAPGF Filament_head X X -ROCK1 ROCK1 Q13464 human AQP2 359 P41181 AQP2 human T269 3339002 PQsLPRGtkA_____ X X -ROCK1 ROCK1 Q13464 human FHOD1 29109 Q9Y613 FHOD1 human S1131 451843 AARERKRsRGNRKsL X X -ROCK1 ROCK1 Q13464 human PRMT5 10419 O14744 PRMT5 human T80 62906108 LsGRDWNtLIVGkLS PRMT5_TIM X -ROCK1 ROCK1 Q13464 human MRLC1 296313 Q64122 Myl9 rat S20 1863500 KRPQSAtsNVFAMFD X X 3674; 3671; 3675; 95777 -ROCK1 ROCK1 Q13464 human RhoE 390 P61587 RND3 human S11 455489 RRAsQkLsSksIMDP X X -ROCK1 ROCK1 Q13464 human MRLC1 10398 P24844 MYL9 human T19 1863501 KKRPQRAtsNVFAMF X 3674; 95777 -ROCK1 ROCK1 Q13464 human desmin 1674 P17661 DES human S60 449614 VyQVsRtsGGAGGLG Filament_head X -ROCK1 ROCK1 Q13464 human KCNK3 3777 O14649 KCNK3 human S336 21336507 IPRDLStsDTCVEQS X -ROCK1 ROCK1 Q13464 human ARHGAP24 83478 Q8N264 ARHGAP24 human T452 12518705 GLEKTQTtPNGSLQA X -ROCK1 ROCK1 Q13464 human profilin 1 5216 P07737 PFN1 human S138 2850008 MAsHLRRsQy_____ Profilin X X -ROCK1 ROCK1 Q13464 human RhoE 390 P61587 RND3 human S218 25307985 QRATKRIsHMPsRPE X X -ROCK1 ROCK1 Q13464 human H3 8350 P68431 H3C1 human S10 455676 tkQtArkstGGkAPr Histone X X 9701; 9711; 9606; 3465; 3642; 3377; 3475; 3458; 5764; 47398; 8481; 8552; 53348; 29237; 66065; 43185; 64522; 52725 -ROCK1 ROCK1 Q13464 human calponin 1 396522 P26932 CNN1 chicken T259 469596 GASQQGMtVYGLPRQ Calponin X -ROCK1 ROCK1 Q13464 human calponin 3 71994 Q9DAW9 Cnn3 mouse S293 4776192 QGtGTNGsEIsDsDy X -ROCK1 ROCK1 Q13464 human ARHGAP24 83478 Q8N264 ARHGAP24 human S437 12518706 SGIVTNGsFSSSNAE X -ROCK1 ROCK1 Q13464 human RhoE 390 P61587 RND3 human S7 455488 _MKERRAsQkLsSks X -ROCK1 ROCK1 Q13464 human APP iso2 11820 P12023-2 App mouse S655 448200 LkkkQyTsIHHGVVE APP_amyloid X -ROCK1 ROCK1 Q13464 human Moesin 17698 P26041 Msn mouse T558 447706 LGRDKYKtLRQIRQG ERM_C X 3141; 3726; 32600 -ROCK1 ROCK1 Q13464 human LIMK2 3985 P53671 LIMK2 human T505 448683 NDRKKRYtVVGNPYW PK_Tyr_Ser-Thr X 3841 -ROCK1 ROCK1 Q13464 human calponin 1 396522 P26932 CNN1 chicken S175 450890 MGtNKFAsQQGMtAY Calponin X -ROCK1 ROCK1 Q13464 human GRF-1 2909 Q9NRY4 ARHGAP35 human S1174 7157500 RFASYRtsFsVGsDD RhoGAP_pG1_pG2 X -ROCK1 ROCK1 Q13464 human H3 8350 P68431 H3C1 human S28 455677 ATkAArksAPATGGV Histone X 9713 -ROCK1 ROCK1 Q13464 human MRLC1 296313 Q64122 Myl9 rat T19 1863501 KKRPQSAtsNVFAMF X 3674; 95777 -ROCK1 ROCK1 Q13464 human Vimentin 7431 P08670 VIM human S72 449026 ssAVrLrssVPGVRL Filament_head X X -ROCK1 ROCK1 Q13464 human GFAP 2670 P14136 GFAP human S13 449619 ItsAArrsyVSsGEM Filament_head X X -ROCK1 ROCK1 Q13464 human desmin 1674 P17661 DES human T76 449615 LRAsRLGttRtPssy Filament_head X -ROCK1 ROCK1 Q13464 human MYPT1 396020 Q90623 PPP1R12A chicken T850 452075 PREKRRstGVSFWTQ X X -ROCK1 ROCK1 Q13464 human calponin 1 396522 P26932 CNN1 chicken T184 469595 QGMtAYGtRRHLYDP Calponin X -ROCK1 ROCK1 Q13464 human FAK 5747 Q05397 PTK2 human S732 450196 SsEGFYPsPQHMVQT X -ROCK1 ROCK1 Q13464 human PAR-4 5074 Q96IZ0 PAWR human T163 456964 LREKRRstGVVNIPA X 2329 -ROCK1 ROCK1 Q13464 human SOX9 6662 P48436 SOX9 human S181 456981 YQPRRRKsVKNGQAE X X -ROCK1 ROCK1 Q13464 human MYPT1 4659 O14974 PPP1R12A human T853 452075 PREKRRstGVsFWtQ X X 4563 -ROCK1 ROCK1 Q13464 human calponin 1 396522 P26932 CNN1 chicken T180 469594 FAsQQGMtAYGtRRH Calponin X -ROCK1 ROCK1 Q13464 human MYPT1 4659 O14974 PPP1R12A human T696 448587 ARQsRRstQGVtLtD X X 5163 -ROCK1 ROCK1 Q13464 human calponin 3 71994 Q9DAW9 Cnn3 mouse S296 4776198 GTNGsEIsDsDyQAE X -ROCK1 ROCK1 Q13464 human JIP3 23162 Q9UPT6 MAPK8IP3 human S365 486175 RLDRtGssPTQGIVN X X -ROCK1 ROCK1 Q13464 human Scribble 23513 Q14160 SCRIB human S1508 480131 WRAARMksLEQDALR X X -ROCK1 ROCK1 Q13464 human calponin 1 396522 P26932 CNN1 chicken T170 469593 IIGLQMGtNKFAsQQ Calponin X -ROCK1 ROCK1 Q13464 human MARCKS 4082 P29966 MARCKS human S159 447786 kkKKKRFsFkKsFkL MARCKS X 2741; 11992 -ROCK1 ROCK1 Q13464 human RhoE 390 P61587 RND3 human S240 27933601 LRKDKAKsCTVM___ X X -ROCK1 ROCK1 Q13464 human MYPT1 17931 Q9DBR7 Ppp1r12a mouse T694 448587 ARQSRRstQGVTLTD X 5163 -ROCK1 ROCK1 Q13464 human TPPP 11076 O94811 TPPP human S107 31094519 FSKIKGKsCRTITFE p25-alpha X -ROCK1 ROCK1 Q13464 human GFAP 2670 P14136 GFAP human T7 449617 _MERRRItsAArrsy Filament_head X X -ROCK1 ROCK1 Q13464 human GRF-1 2909 Q9NRY4 ARHGAP35 human S1150 457041 LERGRKVsIVsKPVL RhoGAP_pG1_pG2 X X -ROCK1 ROCK1 Q13464 human ARHGAP24 83478 Q8N264 ARHGAP24 human S415 4757012 HKLDVsRsPPLMVkk X -ROCK1 ROCK1 Q13464 human MYPT1 396020 Q90623 PPP1R12A chicken T695 448587 ARQSRRstQGVTLTD X 5163 -ROCK1 ROCK1 Q13464 human ARHGAP19 84986 Q14CB8 ARHGAP19 human S422 3196670 QkRARsRsFsGLIkR X -ROCK1 ROCK1 Q13464 human PAR3-alpha 81918 Q9Z340 Pard3 rat T833 2512944 QsMSEKRtKQFSNAS X -ROCK1 ROCK1 Q13464 human MRLC2 103910 O14950 MYL12B human S20 448595 KRPQRAtsNVFAMFD X X -ROCK1 ROCK1 Q13464 human CRMP-2 1808 Q16555 DPYSL2 human T555 448084 DNIPRRttQRIVAPP X X -ROCK1 ROCK1 Q13464 human TPPP 11076 O94811 TPPP human S159 487537 sGVtKAIssPtVSRL p25-alpha X -ROCK1 ROCK1 Q13464 human GRF-1 2909 Q9NRY4 ARHGAP35 human T1226 7159800 LRsLRRNtKKPKPKP RhoGAP_pG1_pG2 X -ROCK1 ROCK1 Q13464 human ADD1 118 P35611 ADD1 human T445 449480 QkQQREKtRWLNSGR X X -ROCK1 ROCK1 Q13464 human GR 2908 P04150 NR3C1 human T519 1872513502 SENPGNKtIVPAtLP X -ROCK1 ROCK1 Q13464 human MRLC1 10398 P24844 MYL9 human S20 1863500 KRPQRAtsNVFAMFD X X 3674; 3671; 3675; 95777 -ROCK1 ROCK1 Q13464 human desmin 1674 P17661 DES human T77 449616 RAsRLGttRtPssyG Filament_head X -ROCK1 ROCK1 Q13464 human ADD1 118 P35611 ADD1 human T480 449481 TKEDGHRtstsAVPN X X -ROCK1 ROCK1 Q13464 human Scribble 23513 Q14160 SCRIB human S1378 470678 EGPPKRVsLVGADDL X X -ROCK1 ROCK1 Q13464 human Moesin 4478 P26038 MSN human T558 447706 LGRDKyKtLRQIRQG ERM_C X X 3141; 3726; 32600 -ROCK1 ROCK1 Q13464 human NFL 281348 P02548 NEFL cow S27 457196 ETPRVHIsSVRSGYS Filament_head X -ROCK1 ROCK1 Q13464 human GR 2908 P04150 NR3C1 human S617 1872513503 WRSYRQSsANLLCFA Hormone_recep X -ROCK1 ROCK1 Q13464 human MYPT1 396020 Q90623 PPP1R12A chicken S849 451999 RPREKRRstGVSFWT X -ROCK1 ROCK1 Q13464 human AQP2 11827 P56402 Aqp2 mouse S269 3339002 PQsLPRGskA_____ X -ROCK1 ROCK1 Q13464 human MRLC2 531505 Q5E9E2 MYL12A cow S20 448595 KRPQRAtsNVFAMFD X -ROCK1 ROCK1 Q13464 human PPP1R12B 4660 O60237 PPP1R12B human T646 478177 ARQtRRstQGVtLtD X X -ROCK1 ROCK1 Q13464 human ARHGAP24 83478 Q8N264 ARHGAP24 human S413 12518707 sVHKLDVsRsPPLMV X -ROCK1 ROCK1 Q13464 human DAPK3 1613 O43293 DAPK3 human T265 454892 KDPKRRMtIAQSLEH Pkinase X X -ROCK1 ROCK1 Q13464 human MRLC2 103910 O14950 MYL12B human T19 448596 KKRPQRAtsNVFAMF X X -ROCK1 ROCK1 Q13464 human NFL 281348 P02548 NEFL cow S58 457405 LSVRRsYsSSSGsLM Filament_head X -ROCK1 ROCK1 Q13464 human ARHGAP24 83478 Q8N264 ARHGAP24 human S402 4757006 LSGsKTNsPKNsVHK X -ROCK1 ROCK1 Q13464 human desmin 1674 P17661 DES human S12 449612 ysSSQRVssYRRtFG Filament_head X -ROCK1 ROCK1 Q13464 human LIMK1 3984 P53667 LIMK1 human T508 447808 PDRKKRYtVVGNPYW PK_Tyr_Ser-Thr X X 3841 -ROCK1 ROCK1 Q13464 human DAPK3 1613 O43293 DAPK3 human T299 454893 PERRRLKtTRLkEyt X -ROCK1 ROCK1 Q13464 human TIAM2 24001 Q6ZPF3 Tiam2 mouse T1662 478913 STKRGRGtLLKAQTR X -ROCK1 ROCK1 Q13464 human MRLC2 531505 Q5E9E2 MYL12A cow T19 448596 KKRPQRAtsNVFAMF X -ROCK1 ROCK1 Q13464 human MYPT1 17931 Q9DBR7 Ppp1r12a mouse T852 452075 PREKRRstGVSFWtQ X 4563 -ROCK1 ROCK1 Q13464 human JIP3 23162 Q9UPT6 MAPK8IP3 human S314 26340500 RAREKRDsRNMEVQV X X -ROCK1 ROCK1 Q13464 human TPPP 11076 O94811 TPPP human S32 456613 DRAAKRLsLEsEGAG X -ROCK1 ROCK1 Q13464 human JIP3 23162 Q9UPT6 MAPK8IP3 human S364 2025497 TRLDRtGssPTQGIV X X -ROCK1 ROCK1 Q13464 human PTEN 5728 P60484 PTEN human T232 456214 YSsNsGPtRREDKFM PTEN_C2 X X -ROCK1 ROCK1 Q13464 human KCNK3 3777 O14649 KCNK3 human S393 2840504 GLMKRRssV______ X -ROCK1 ROCK1 Q13464 human MYPT1 4659 O14974 PPP1R12A human S852 451999 RPREKRRstGVsFWt X -Map3k7 TAK1 Q62073 mouse RIPK1 19766 Q60855 Ripk1 mouse S321 468644 PVLQRMFsLQHDCVP X 83613; 38662 -Map3k7 TAK1 Q62073 mouse RIPK1 19766 Q60855 Ripk1 mouse S334 4728178 VPLPPsRsNsEQPGS X -Map3k7 TAK1 Q62073 mouse SQSTM1 18412 Q64337 Sqstm1 mouse S351 14580829 SsKEVDPsTGELQsL X 95697; 16177; 12074 -Map3k7 TAK1 Q62073 mouse TAK1 6885 O43318 MAP3K7 human T187 454704 CDIQtHMtNNKGsAA PK_Tyr_Ser-Thr X 4536; 4531; 4508 -Map3k7 TAK1 Q62073 mouse RIPK1 19766 Q60855 Ripk1 mouse S332 4728172 DCVPLPPsRsNsEQP X -Map3k7 TAK1 Q62073 mouse KSR 16706 Q61097 Ksr1 mouse S392 449297 ARLRRtEsVPsDINN X X 4951 -Map3k7 TAK1 Q62073 mouse TAK1 26409 Q62073 Map3k7 mouse S192 448289 HMtNNKGsAAWMAPE PK_Tyr_Ser-Thr X X -CERT1 COL4A3BP Q9Y5P4 human COL4A3 1285 Q01955 COL4A3 human S1435 1247500 LKGKRGDsGSPATWT Collagen X -PKM PKM iso2 P14618-2 human BUB3 9184 O43684 BUB3 human Y207 463080 EGRVAVEyLDPsPEV X X -PKM PKM iso2 P14618-2 human H3 8350 P68431 H3C1 human T11 455680 kQtArkstGGkAPrk Histone X X 9767; 9764 -PKM PKM iso2 P14618-2 human STAT3 6774 P40763 STAT3 human Y705 448192 DPGsAAPyLktKFIC X 4093; 9145; 4324; 9131; 9138; 4323; 4074; 4113; 48313; 20977; 25023; 8119; 52075; 52527; 73533; 61958; 73452; 16185; 74309 -NEK5 NEK5 Q6P3R8 human TTLL4 67534 Q80UG8 Ttll4 mouse S1136 36123708 KKsQAGLsPIsRKTL X -NEK5 NEK5 Q6P3R8 human TTLL4 67534 Q80UG8 Ttll4 mouse T813 1873647200 YSVNKKNtEyQANAD TTL X -NEK5 NEK5 Q6P3R8 human TTLL4 9654 Q14679 TTLL4 human S912 1873645600 LEVNISPsLHSSSPL TTL X -NEK5 NEK5 Q6P3R8 human TTLL4 67534 Q80UG8 Ttll4 mouse Y815 1873647202 VNKKNtEyQANADET TTL X -NEK5 NEK5 Q6P3R8 human TTLL4 67534 Q80UG8 Ttll4 mouse S1139 1873647208 QAGLsPIsRKTLSSR X -NEK5 NEK5 Q6P3R8 human TTLL4 67534 Q80UG8 Ttll4 mouse T968 1873647206 PRDKCQMtPEHFTAQ X -FER Fer P16591 human PKCD 5580 Q05655 PRKCD human Y374 464424 ELkGRGEyFAIKALK Pkinase X X -FER Fer P16591 human CRMP-2 1808 Q16555 DPYSL2 human Y499 463170 rGVPRGLyDGPVCEV X -FER Fer P16591 human Met 4233 P08581 MET human Y1349 448472 stFIGEHyVHVNAty X 3133; 3121 -FER Fer P16591 human Fer 2241 P16591 FER human Y402 457934 EPPPVVNyEEDARsV X -FER Fer P16591 human Cortactin 13043 Q60598 Cttn mouse Y421 447702 RPPssPIyEDAAPFK X 4569 -FER Fer P16591 human IRS4 8471 O14654 IRS4 human Y921 456294 EADSSsDyVNMDFTk X -FER Fer P16591 human IRS4 8471 O14654 IRS4 human Y828 456293 GQNDNsEyVPMLPGk X -FER Fer P16591 human PTP1B 395688 O13016 PTPN1 chicken Y152 449312 ISEDIKSyyTVRQLE Y_phosphatase X -FER Fer P16591 human Cortactin 13043 Q60598 Cttn mouse Y482 447704 yQAEDDTyDGYESDL X -FER Fer P16591 human STAT3 6774 P40763 STAT3 human Y705 448192 DPGsAAPyLktKFIC X 4093; 9145; 4324; 9131; 9138; 4323; 4074; 4113; 48313; 20977; 25023; 8119; 52075; 52527; 73533; 61958; 73452; 16185; 74309 -FER Fer P16591 human Fer 2241 P16591 FER human Y615 6311907 EAkILkQyDHPNIVK PK_Tyr_Ser-Thr X -FER Fer P16591 human IRS4 8471 O14654 IRS4 human Y847 1877150802 GLDkEVSyNWDPKDA X -FER Fer P16591 human Ezrin 7430 P15311 EZR human Y478 454875 PPPPPPVyEPVsyHV X -FER Fer P16591 human SKOR1 207667 Q8BX46 Skor1 mouse Y234 1881001402 HRTPDAKyTQPDAAN X X -FER Fer P16591 human AR 367 P10275 AR human Y225 1243004 PtsSKDNyLGGTSTI Androgen_recep X X -FER Fer P16591 human IRS4 8471 O14654 IRS4 human Y656 1877150800 SGGRFRLyFCVDrGA X -FER Fer P16591 human PECAM-1 18613 Q08481 Pecam1 mouse Y679 448759 PQNMDVEyTEVEVSS X -FER Fer P16591 human IRS4 8471 O14654 IRS4 human Y779 10781335 DNDsEsDyMFMAPGA X -FER Fer P16591 human CTNNB1 12387 Q02248 Ctnnb1 mouse Y142 449044 AVVNLINyQDDAELA X -FER Fer P16591 human CRMP-2 1808 Q16555 DPYSL2 human Y479 18833900 kPFPDFVyKRIKARS X X -FER Fer P16591 human Ezrin 7430 P15311 EZR human Y354 448105 LMLRLQDyEEktKKA ERM_helical X 3144; 5484 -FER Fer P16591 human ERK2 5594 P28482 MAPK1 human Y187 447594 HtGFLtEyVAtRWyr Pkinase X X 9106; 4370; 4374; 9101; 4375; 4376; 4377; 3510; 5726; 88569; 13214; 13148; 70235; 9488; 89967; 8544; 14196; 14227; 14095; 14474; 75165; 98168; 33370; 54240; 15892; 45899; 55088; 9524; 69217; 48735 -FER Fer P16591 human Cortactin 13043 Q60598 Cttn mouse Y466 447703 TyTSEPVyETTEAPG X -FER Fer P16591 human NSF 4905 P46459 NSF human Y83 453414 QEIEVSLyTFDKAKQ CDC48_N X -FER Fer P16591 human Fer 2241 P16591 FER human Y714 448461 RQEDGGVyssSGLkQ PK_Tyr_Ser-Thr X -FER Fer P16591 human Ezrin 7430 P15311 EZR human Y146 448758 kEVHksGyLSsERLI FERM_M X -FER Fer P16591 human CTNNG 3728 P14923 JUP human Y550 456972 AAGtQQPytDGVRME X -FER Fer P16591 human GAB1 2549 Q13480 GAB1 human Y627 447948 KGDKQVEyLDLDLDs X 3231; 3233 -PRKG2 PKG2 Q13237 human eNOS 4846 P29474 NOS3 human T495 447885 TGITRKKtFKEVANA X 9574 -PRKG2 PKG2 Q13237 human NHE3 100009430 P26432 NHE-3 rabbit S663 457469 TMRKRLEsFKSAKLG X -PRKG2 PKG2 Q13237 human STAR 25557 P97826 Star rat S99 450441 QEGWKKEsQQENGDE START X -PRKG2 PKG2 Q13237 human GCAP2 286851 P51177 GUCA1B cow S201 455322 ISQQRRKsAMF____ X -PRKG2 PKG2 Q13237 human SHP-1 5777 P29350 PTPN6 human S557 11086952 AKAsRtssKHkEDVy X -PRKG2 PKG2 Q13237 human STAR 25557 P97826 Star rat S55 450439 MGQVRRRssLLGSQL X -PRKG2 PKG2 Q13237 human PDGFRB 5159 P09619 PDGFRB human S712 23130549 sDkRRPPsAELysNA PK_Tyr_Ser-Thr X -PRKG2 PKG2 Q13237 human MRF 225908 Q3UR85 Myrf mouse S259 20804942 PSKKRKHsEsPPNTL X -PRKG2 PKG2 Q13237 human ICLN 403971 P35521 CLNS1A dog S2 6745600 ______MsFLKSFPP X -PRKG2 PKG2 Q13237 human STAR 25557 P97826 Star rat S56 450440 GQVRRRssLLGSQLE X -PRKG2 PKG2 Q13237 human HCN2 15166 O88703 Hcn2 mouse S641 18454000 DRIGKKNsILLHKVQ X -PRKG2 PKG2 Q13237 human EGFR 1956 P00533 EGFR human T430 1876620106 LEIIRGRtKQHGQFS Recep_L_domain X X -PRKG2 PKG2 Q13237 human PDGFRB 5159 P09619 PDGFRB human S254 1876167502 WTYPRKEsGRLVEPV Ig_3 X -PRKG2 PKG2 Q13237 human CTH 1491 P32929 CTH human S377 484505 SDTLIRLsVGLEDEE Cys_Met_Meta_PP X -PRKG2 PKG2 Q13237 human ICLN 403971 P35521 CLNS1A dog S93 6745601 FGEESKEsVAEEEDS Voldacs X -PRKG2 PKG2 Q13237 human NHE3 100009430 P26432 NHE-3 rabbit S554 450899 TEGERRGsLAFIRSP X X -PRKG2 PKG2 Q13237 human HER2 2064 P04626 ERBB2 human T686 451817 QQKIRKYtMRRLLQE X 88583 -PRKG2 PKG2 Q13237 human SHP-1 5777 P29350 PTPN6 human S556 15406102 HAKAsRtssKHkEDV X -PRKG2 PKG2 Q13237 human mAChR M3 P41984 CHRM3 cow S482 23940032 ITKRKRMsLIKEKKA 7tm_1 X -PRKG2 PKG2 Q13237 human NHE3 100009430 P26432 NHE-3 rabbit S607 450900 SLEQRRRsVRDAEDV X X -PRKG2 PKG2 Q13237 human eNOS 4846 P29474 NOS3 human S1177 447884 TSRIRtQsFsLQERQ X 9571; 9570 -PRKG2 PKG2 Q13237 human eNOS 4846 P29474 NOS3 human S633 448637 WRRKRKEssNtDsAG Flavodoxin_1 X -PRKG2 PKG2 Q13237 human Lasp-1 3927 Q14847 LASP1 human S146 448836 MEPERRDsQDGssyR X -PRKG2 PKG2 Q13237 human EGFR 1956 P00533 EGFR human T693 448054 RELVEPLtPsGEAPN X 3056; 8808 -PRKG2 PKG2 Q13237 human ICLN 403971 P35521 CLNS1A dog S45 456841 YIAESRLsWLDGSGL Voldacs X -PRKG2 PKG2 Q13237 human SHP-1 5777 P29350 PTPN6 human S553 15415001 kNAHAKAsRtssKHk X -PRKG2 PKG2 Q13237 human PTS 5805 Q03393 PTS human S19 450662 AQVSRRIsFSASHRL PTPS X X -PRKG2 PKG2 Q13237 human Met 4233 P08581 MET human S985 450188 PHLDRLVsARsVsPt X -PRKG1 PKG1 P00516 cow GluR2 29627 P19491 Gria2 rat S697 10306402 KMWTYMRsAEPSVFV Lig_chan X -PRKG1 PKG1 P00516 cow PTRF 287710 P85125 Cavin1 rat T304 2566127 DKLRKsFtPDHVVyA PTRF_SDPR X -PRKG1 PKG1 P00516 cow CACNA1C 100101555 P15381 CACB rabbit S1928 455278 ASLGRRAsFHLECLK CAC1F_C X -PRKG1 PKG1 P00516 cow GSBS 10842 O96001 PPP1R17 human T68 2999005 KKPRRKDtPALHIPP X -PRKG1 PKG1 P00516 cow Arp3 81732 Q4V7C7 Actr3 rat T257 2566207 SkWIkQYtGVNAISK Actin X -PRKG1 PKG1 P00516 cow GCAP2 286851 P51177 GUCA1B cow S201 455322 ISQQRRKsAMF____ X -PRKG1 PKG1 P00516 cow PKG1 282004 P00516 PRKG1 cow T85 452151 RQAFRKFtKSERSKD X -PRKG1 PKG1 P00516 cow HMGN1 614915 P02316 HMGN1 cow S25 454112 KRRSARLsAKPAPAK HMG14_17 X -PRKG1 PKG1 P00516 cow CACNB2 100009277 P54288 CAB2 rabbit S522 486359 SGTSRGLsRQETFDS X -PRKG1 PKG1 P00516 cow MRVI1 10335 Q9Y6F6 IRAG1 human S689 485352 NMPRRRVsVAVVPKF MRVI1 X -PRKG1 PKG1 P00516 cow smMLCK 100009143 P29294 MYLK rabbit S1011 468782 SsTGSPTsPLTAERL X -PRKG1 PKG1 P00516 cow GSBS 10842 O96001 PPP1R17 human T119 2999004 kKPRRKDtPALHMSP X -PRKG1 PKG1 P00516 cow PKG1 282004 P00516 PRKG1 cow S27 452152 KELEKRLsEKEEEIQ PKcGMP_CC X -PRKG1 PKG1 P00516 cow CACNA1C 100101555 P15381 CACB rabbit S533 453091 RIsKSKFsRYWRRWN X -PRKG1 PKG1 P00516 cow SF1 117855 NP_001104263 Sf1 rat S20 449919 PSkKRKRsRWNQDTM SF1-HH X -PRKG1 PKG1 P00516 cow H2B 615043 P62808 H2BC19 cow S32 447801 DGKKRKRsRKEsYSV Histone X -PRKG1 PKG1 P00516 cow PTRF 287710 P85125 Cavin1 rat S368 452129 TDLLRGssPDVHTLL X -PRKG1 PKG1 P00516 cow DMN 308709 Q810D0 Synm rat S777 2565443 EVDDVsPsPKGFIEE X -PRKG1 PKG1 P00516 cow MDH1 24551 O88989 Mdh1 rat S241 1210666 VIkARKLsSAMSAAK Ldh_1_C X -PRKG1 PKG1 P00516 cow GKAP1 56278 Q9JMB0 Gkap1 mouse S106 12524600 PNPAQKEsREENWQE X X -PRKG1 PKG1 P00516 cow PKG1 282004 P00516 PRKG1 cow T59 448837 THIGPRTtRAQGIsA X -PRKG1 PKG1 P00516 cow PDE5A 8654 O76074 PDE5A human S102 448178 GTPTRKIsAsEFDRP X -PRKG1 PKG1 P00516 cow VASP 7408 P50552 VASP human S239 448380 GAKLRKVsKQEEASG X 3114; 37565 -PRKG1 PKG1 P00516 cow smMLCK 100009143 P29294 MYLK rabbit S1005 455821 GLSGRKSsTGSPTsP X -PRKG1 PKG1 P00516 cow PKAR1A 615074 P00514 PRKAR1A cow S100 454354 RRRRGAIsAEVYTEE X -PRKG1 PKG1 P00516 cow HMGN1 614915 P02316 HMGN1 cow S7 447788 _MPKRKVsSAEGAAK HMG14_17 X -PRKG1 PKG1 P00516 cow PTRF 287710 P85125 Cavin1 rat S302 465873 SRDKLRKsFtPDHVV PTRF_SDPR X -PRKG1 PKG1 P00516 cow SEPT3 56003 Q9WU34 Septin3 rat S91 453431 SQVSRKAsSWNREEK Septin X -PRKG1 PKG1 P00516 cow PKG1 282004 P00516 PRKG1 cow S51 452149 QsVLPVPsTHIGPRT X -PRKG1 PKG1 P00516 cow HMGN2 P02313 HMGN2 cow S29 2574920 QRRSARLsAKPAPPK HMG14_17 X -PRKG1 PKG1 P00516 cow RIL 24915 P36202 Pdlim4 rat S119 468635 PATsRRssIsGIsLE X -PRKG1 PKG1 P00516 cow H1C 513971 P02253 H1-2 cow S36 450120 AGARRKAsGPPVSEL X -PRKG1 PKG1 P00516 cow CACNA1C 100101555 P15381 CACB rabbit S528 486358 ARLAHRIsKSKFsRY X -PRKG1 PKG1 P00516 cow CFTR 1080 P13569 CFTR human S660 449979 FSAERRNsILTETLH CFTR_R X -PRKG1 PKG1 P00516 cow MCAM 78967 Q9EPF2 Mcam rat S426 2565319 LNRTRRVsVGIFGSP X -PRKG1 PKG1 P00516 cow PKG1 282004 P00516 PRKG1 cow S45 452150 RKLHKCQsVLPVPsT X -PRKG1 PKG1 P00516 cow PKG1 282004 P00516 PRKG1 cow S65 452147 TtRAQGIsAEPQTYR X -PRKG1 PKG1 P00516 cow smMLCK 288057 D3ZFU9 Mylk rat S1816 455821 GLsGRKSsTGsPTsP X -PRKG1 PKG1 P00516 cow AKAP12 83425 Q5QD51 Akap12 rat S614 476343 KKRVRRPsESDKEEE WSK X -PRKG1 PKG1 P00516 cow Titin iso2 84015 Q7TMZ9 Ttn rat S935 2312300 GNGKAMTsAKLTVGE I-set X -PRKG1 PKG1 P00516 cow SERPINA1 24648 P17475 Serpina1 rat S45 2565355 SPTYRKIsSNLADFA X -PRKG1 PKG1 P00516 cow CFTR 1080 P13569 CFTR human S700 449978 FGEKRkNsILNPINs CFTR_R X -PRKG1 PKG1 P00516 cow H2B 615043 P62808 H2BC19 cow S36 449903 RKRsRKEsYSVYVYK Histone X -PRKG1 PKG1 P00516 cow PTRF 287710 P85125 Cavin1 rat S367 452128 ETDLLRGssPDVHTL X -PRKG1 PKG1 P00516 cow PKG1 282004 P00516 PRKG1 cow T517 452153 GFGKKTWtFCGTPEY Pkinase X -PRKG1 PKG1 P00516 cow PKG1 282004 P00516 PRKG1 cow S73 452148 AEPQTYRsFHDLRQA X -PRKG1 PKG1 P00516 cow VASP 7408 P50552 VASP human S157 448379 EHIERRVsNAGGPPA X 3111; 84519 -PRKG1 PKG1 P00516 cow HSP20 126393 O14558 HSPB6 human S16 450706 PSWLRRAsAPLPGLS Crystallin X 36519 -PRKG1 PKG1 P00516 cow RIL 24915 P36202 Pdlim4 rat S118 481133 sPATsRRssIsGIsL X -CKB CKB P05122 chicken CKB 396248 P05122 CKB chicken T289 451826 tCPsNLGtGLRAGVH ATP-gua_Ptrans X -CKB CKB P05122 chicken CKB 396248 P05122 CKB chicken T282 451824 PHLGYILtCPsNLGt ATP-gua_Ptrans X -CKB CKB P05122 chicken CKB 396248 P05122 CKB chicken S285 451825 GYILtCPsNLGtGLR ATP-gua_Ptrans X -Ptk2b Pyk2 P70600 rat GJA1 24392 P08050 Gja1 rat Y313 454254 sEQNWANysAEQNRM Connexin43 X X -Ptk2b Pyk2 P70600 rat GJA1 24392 P08050 Gja1 rat Y265 447815 kDCGsPkyAyFNGCS X X -Ptk2b Pyk2 P70600 rat Hic-5 7041 O43294 TGFB1I1 human Y60 450964 SGDKDHLystVCKPR Paxillin X -Ptk2b Pyk2 P70600 rat PXN 360820 Q66H76 Pxn rat Y31 448785 FLSEEPPySYPTGNH X -Ptk2b Pyk2 P70600 rat Src 83805 Q9WUD9 Src rat Y419 448234 RLIEDNEyTARQGAk PK_Tyr_Ser-Thr X 2101; 6943; 59548; 70926; 78740; 94361; 17320 -Ptk2b Pyk2 P70600 rat PXN 360820 Q66H76 Pxn rat Y118 448604 AGEEEHVySFPNKQK Paxillin X 2541; 69363 -Ptk2b Pyk2 P70600 rat GJA1 24392 P08050 Gja1 rat Y267 465295 CGsPkyAyFNGCSSP X -Ptk2b Pyk2 P70600 rat JAK2 24514 Q62689 Jak2 rat Y1008 448408 LPQDKEyyKVKEPGE PK_Tyr_Ser-Thr X 3771; 3776; 8082; 66245 -Ptk2b Pyk2 P70600 rat JAK2 24514 Q62689 Jak2 rat Y1007 448407 VLPQDKEyyKVKEPG PK_Tyr_Ser-Thr X 3771; 3776; 4406; 66245 -Ptk2b Pyk2 P70600 rat Pyk2 50646 P70600 Ptk2b rat Y402 447955 CSIESDIyAEIPDET X 3291 -Ptk2b Pyk2 P70600 rat GJA1 24392 P08050 Gja1 rat Y247 447814 VKGRsDPyHATTGPL X X -CDKL2 CDKL2 Q92772 human BPY2-IP1 55201 Q66K74 MAP1S human S900 476391 DrAsRPLsARsEPsE X -Map2k4 MKK4 P47809 mouse JNK2 26420 Q9WTU6 Mapk9 mouse T183 447649 ACTNFMMtPyVVtRY Pkinase X X -Map2k4 MKK4 P47809 mouse JNK2 26420 Q9WTU6 Mapk9 mouse Y185 447652 TNFMMtPyVVtRYYR Pkinase X X -Map2k4 MKK4 P47809 mouse JNK1 26419 Q91Y86 Mapk8 mouse T183 447643 AGtsFMMtPyVVtRY Pkinase X X 5136; 4668; 4671; 9257; 9255; 9251; 4306; 5755; 16014; 58328 -Map2k4 MKK4 P47809 mouse JNK1 26419 Q91Y86 Mapk8 mouse Y185 447645 tsFMMtPyVVtRYYR Pkinase X X 5136; 4668; 4671; 9257; 9255; 9251; 4306; 5755; 16014; 58328 -CDK9 CDK9 P50750 human SIRT1 23411 Q96EB6 SIRT1 human S47 452899 DGPGLERsPGEPGGA X 2314 -CDK9 CDK9 P50750 human BAF53A 86 O96019 ACTL6A human S233 471130 kEAVREGsPANWkRk Actin X -CDK9 CDK9 P50750 human SMAD1 4086 Q15797 SMAD1 human S195 451174 PNSSYPNsPGSSSSt X -CDK9 CDK9 P50750 human SMAD1 4086 Q15797 SMAD1 human S187 451173 NSHPFPHsPNSSYPN X -CDK9 CDK9 P50750 human CDK9 1025 P50750 CDK9 human T186 450950 NSQPNRYtNRVVTLW Pkinase X 2549 -CDK9 CDK9 P50750 human OGFOD1 55239 Q8N543 OGFOD1 human S256 1874115106 FEPPIPRsPHIPQDH X -CDK9 CDK9 P50750 human p73 7161 O15350 TP73 human T86 449047 AASASPYtPEHAASV X -CDK9 CDK9 P50750 human SPT5 6829 O00267 SUPT5H human T784 458816 MyGsGsrtPMyGsQt X X -CDK9 CDK9 P50750 human H1F1 3024 Q02539 H1-1 human S183 15605000 KPKKVAKsPAKAKAV X X -CDK9 CDK9 P50750 human POLR2A 5430 P24928 POLR2A human T1525 1239966001 TPWNQGAtPAYGAWS X -CDK9 CDK9 P50750 human BORA 79866 Q6PGQ7 BORA human S325 4753166 sPYIDGCsPIKNWsP X X -CDK9 CDK9 P50750 human SPT5 6829 O00267 SUPT5H human T775 458815 tPMyGsQtPMyGsGs X X -CDK9 CDK9 P50750 human PPAR-gamma 5468 P37231 PPARG human S112 448062 AIkVEPAsPPYYSEK X -CDK9 CDK9 P50750 human CDK9 1025 P50750 CDK9 human S353 4271605 GsQItQQstNQsRNP X -CDK9 CDK9 P50750 human SPT5 6829 O00267 SUPT5H human T768 458814 MtStyGRtPMyGsQt X X -CDK9 CDK9 P50750 human SMAD1 4086 Q15797 SMAD1 human S206 451175 SSStYPHsPTSSDPG X X 9553; 5753 -CDK9 CDK9 P50750 human Rb 5925 P06400 RB1 human S795 447979 sPykFPssPLrIPGG Rb_C X 9301 -CDK9 CDK9 P50750 human MBP 618684 P02687 MBP cow S164 451833 GRDsRSGsPMARR__ Myelin_MBP X -CDK9 CDK9 P50750 human p53 7157 P04637 TP53 human S392 447535 FktEGPDsD______ X 9281 -CDK9 CDK9 P50750 human p53 7157 P04637 TP53 human S33 447531 LPENNVLsPLPsQAM X X 2526 -CDK9 CDK9 P50750 human MBP 618684 P02687 MBP cow T97 450929 KNIVtPRtPPPSQGK Myelin_MBP X -CDK9 CDK9 P50750 human CDK9 1025 P50750 CDK9 human T363 3681503 QsRNPAttNQtEFEr X -CDK9 CDK9 P50750 human SRC-2 10499 Q15596 NCOA2 human S487 4728845 GQPTSMLsPrHRMsP NCOA_u2 X -CDK9 CDK9 P50750 human SMAD1 4086 Q15797 SMAD1 human S214 451176 PTSSDPGsPFQMPAD X -CDK9 CDK9 P50750 human SMAD3 4088 P84022 SMAD3 human T179 451177 PQSNIPEtPPPGYLS X X -CDK9 CDK9 P50750 human SMAD3 4088 P84022 SMAD3 human S213 451180 NLsPNPMsPAHNNLD X -CDK9 CDK9 P50750 human H1E 3008 P10412 H1-4 human S187 458354 KPKKAPKsPAKAkAV X -CDK9 CDK9 P50750 human SPT5 6829 O00267 SUPT5H human T814 458820 PLHDGsRtPAQsGAW X X -CDK9 CDK9 P50750 human RCHY1 25898 Q96PM5 RCHY1 human T217 27971903 PsEYQNMtVDILCND zinc_ribbon_6 X X -CDK9 CDK9 P50750 human SMAD3 4088 P84022 SMAD3 human S208 451179 DAGsPNLsPNPMsPA X -CDK9 CDK9 P50750 human RCHY1 25898 Q96PM5 RCHY1 human S211 27971904 VAQTPMPsEYQNMtV zinc_ribbon_6 X X -CDK9 CDK9 P50750 human MDM2 4193 Q00987 MDM2 human S166 448130 SsRRRAIsEtEENsD X 3521 -CDK9 CDK9 P50750 human SPT5 6829 O00267 SUPT5H human T806 458819 tPHyGsQtPLHDGsR X X -CDK9 CDK9 P50750 human POLR2A 5430 P24928 POLR2A human S1616 450204 TPQSPSysPtsPsYS RNA_pol_Rpb1_R X X 4735; 13499; 13546; 31262 -CDK9 CDK9 P50750 human XRN2 22803 Q9H0D6 XRN2 human T439 3211959 FtPsGILtPHALGsR XRN_M X X -CDK9 CDK9 P50750 human CDK9 1025 P50750 CDK9 human T362 3681501 NQsRNPAttNQtEFE X -CDK9 CDK9 P50750 human SPT5 6829 O00267 SUPT5H human T799 458818 PLQDGsRtPHyGsQt X X -CDK9 CDK9 P50750 human SPT5 6829 O00267 SUPT5H human S782 4948434 tPMyGsGsrtPMyGs X -CDK9 CDK9 P50750 human SPT5 6829 O00267 SUPT5H human S773 15415344 GRtPMyGsQtPMyGs X -CDK9 CDK9 P50750 human POLR2A 5430 P24928 POLR2A human S1621 3439802 SysPtsPsYSPTSPS RNA_pol_Rpb1_R X 13780 -CDK9 CDK9 P50750 human SPT5 6829 O00267 SUPT5H human T791 458817 tPMyGsQtPLQDGsR X X -CDK9 CDK9 P50750 human MED1 5469 Q15648 MED1 human T1032 458308 SSSNRPFtPPTsTGG X X -CDK9 CDK9 P50750 human AR 367 P10275 AR human S83 448714 QQQQQETsPRQQQQQ Androgen_recep X -CDK9 CDK9 P50750 human POLR2A 5430 P24928 POLR2A human T1618 25042600 QSPSysPtsPsYSPT RNA_pol_Rpb1_R X 14934; 26319 -CDK9 CDK9 P50750 human SRC-2 10499 Q15596 NCOA2 human S493 468245 LsPrHRMsPGVAGsP NCOA_u2 X -CDK9 CDK9 P50750 human POLR2A 5430 P24928 POLR2A human T1540 1239966000 PSVGSGMtPGAAGFS X -CDK9 CDK9 P50750 human POLR2A 5430 P24928 POLR2A human S1619 447616 SPSysPtsPsYSPTS RNA_pol_Rpb1_R X X 4735; 13523; 13546; 67221 -CDK9 CDK9 P50750 human SPT5 6829 O00267 SUPT5H human S666 468817 VGGFAPMsPrISsPM X -CDK9 CDK9 P50750 human BAF53A 86 O96019 ACTL6A human S195 1876807200 LQQGIVksPLAGDFI Actin X -CDK9 CDK9 P50750 human BAF53A 86 O96019 ACTL6A human S86 18908932 RENMEAIsPLkNGMV Actin X -CDK9 CDK9 P50750 human Rb 5925 P06400 RB1 human S807 447980 PGGNIyIsPLksPyk Rb_C X 9308; 8974; 4277; 40283; 8957; 8516; 11917; 99274; 41359; 75864; 72443 -CDK9 CDK9 P50750 human CDK9 1025 P50750 CDK9 human S347 3681502 APPRRkGsQItQQst X -CDK9 CDK9 P50750 human MCEF 27125 Q9UHB7 AFF4 human S388 470820 KDDLKLsssEDsDGE AF-4 X -CDK9 CDK9 P50750 human SRC-2 10499 Q15596 NCOA2 human S499 4728850 MsPGVAGsPrIPPSQ NCOA_u2 X -CDK9 CDK9 P50750 human Rb 5925 P06400 RB1 human S811 448717 IyIsPLksPykIsEG Rb_C X 9308; 8974; 4277; 40283; 8957; 8516; 11917; 41359; 75864; 63276 -CDK9 CDK9 P50750 human p53 7157 P04637 TP53 human S315 447530 LPNNtsssPQPkkkP X 2528 -CDK9 CDK9 P50750 human SRC-2 10499 Q15596 NCOA2 human S469 4728825 NYALKMNsPsQSsPG NCOA_u2 X -CDK9 CDK9 P50750 human CDK9 1025 P50750 CDK9 human T354 26367600 sQItQQstNQsRNPA X -Cad CAD P08955 hamster CAD 101843763 P08955 Cad hamster T1037 2861417 QQCRVLGtSPEAIDS X -Taok2 TAO2 Q6ZQ29 mouse SEPT7 235072 O55131 Septin7 mouse T425 476328 EQQnssRtLEKNKKK X -MELK MELK Q14680 human CDC25B 994 P30305 CDC25B human S169 455885 VLRNItNsQAPDGRR M-inducer_phosp X X -MELK MELK Q14680 human MELK 9833 Q14680 MELK human T539 2861410 RGLDkVItVLtRsKR X -MELK MELK Q14680 human MELK 9833 Q14680 MELK human T387 25353601 DLSTGAAtPRTsQFT X -MELK MELK Q14680 human MELK 9833 Q14680 MELK human T494 2861408 TGtDkLMtGVIsPER X X -MELK MELK Q14680 human MELK 9833 Q14680 MELK human S431 2861402 ENVytPKsAVkNEEy X X -MELK MELK Q14680 human MELK 9833 Q14680 MELK human T398 2861401 sQFTkYWtEsNGVEs X X -MELK MELK Q14680 human MELK 9833 Q14680 MELK human T167 456039 NkDyHLQtCCGsLAY Pkinase X X -MELK MELK Q14680 human MELK 9833 Q14680 MELK human S171 2861400 HLQtCCGsLAYAAPE Pkinase X -MELK MELK Q14680 human CDC25B 994 P30305 CDC25B human S323 448409 QRLFRsPsMPCsVIR M-inducer_phosp X -MELK MELK Q14680 human MELK 9833 Q14680 MELK human S405 25353602 tEsNGVEsksLtPAL X -MELK MELK Q14680 human MELK 9833 Q14680 MELK human T409 15412181 GVEsksLtPALCRtP X -MELK MELK Q14680 human MELK 9833 Q14680 MELK human S356 2861407 DIKSNNWsLEDVTAs X X -MELK MELK Q14680 human MELK 9833 Q14680 MELK human Y438 459427 sAVkNEEyFMFPEPK X -MELK MELK Q14680 human MELK 9833 Q14680 MELK human S529 468187 KGAkVFGsLERGLDk X X -MELK MELK Q14680 human MELK 9833 Q14680 MELK human Y367 25353600 VTAsDKNyVAGLIDY X -MELK MELK Q14680 human EIF4B 1975 P23588 EIF4B human S406 470374 RPRERHPsWRsEEtQ X X 8151; 5399 -MELK MELK Q14680 human EZH2 2146 Q15910 EZH2 human S220 25291187 RPPRKFPsDKIFEAI PRC2_HTH_1 X X -MELK MELK Q14680 human ZNF622 52521 Q91VY9 Znf622 mouse T251 63052801 PLGAIPItDCLFCSH zf-C2H2_2 X X -MELK MELK Q14680 human MELK 9833 Q14680 MELK human S505 2861409 sPERRCRsVELDLNQ X X -MELK MELK Q14680 human MELK 9833 Q14680 MELK human S407 2861404 sNGVEsksLtPALCR X -MELK MELK Q14680 human MELK 9833 Q14680 MELK human S336 2861412 PVRLRLssFsCGQAs X -MELK MELK Q14680 human MELK 9833 Q14680 MELK human S343 2861403 sFsCGQAsAtPFtDI X X -MELK MELK Q14680 human MELK 9833 Q14680 MELK human S391 2861405 GAAtPRTsQFTkYWt X -MELK MELK Q14680 human EIF4B 1975 P23588 EIF4B human S422 451290 RERsRtGsEssQtGt X 3591 -MELK MELK Q14680 human MELK 9833 Q14680 MELK human Y163 2861413 kPKGNkDyHLQtCCG Pkinase X -MELK MELK Q14680 human MELK 9833 Q14680 MELK human S253 2861411 VDPKKRIsMkNLLNH Pkinase X -MELK MELK Q14680 human MELK 9833 Q14680 MELK human T56 2861406 sDLPRIktEIEALkN Pkinase X -MAP2K1 MEK1 Q02750 human MyoD 17927 P10085 Myod1 mouse Y156 18755302 ILRNAIRyIEGLQAL HLH X -MAP2K1 MEK1 Q02750 human ERK1 50689 P21708 Mapk3 rat Y205 447543 HTGFLtEyVAtRWYR Pkinase X 9106; 4370; 4374; 9101; 4375; 4376; 4377; 3510; 5726; 88569; 13214; 13148; 70235; 9488; 89967; 8544; 14196; 14227; 14095; 14474; 75165; 98168; 33370; 54240; 15892; 45899; 55088; 9524; 69217; 48735 -MAP2K1 MEK1 Q02750 human Ku70 2547 P12956 XRCC6 human S77 1875071706 VYISKIIssDRDLLA Ku_N X -MAP2K1 MEK1 Q02750 human NPAS4 225872 Q8BGD7 Npas4 mouse S580 1871095702 KLPPsPSsPGNGDCT X X -MAP2K1 MEK1 Q02750 human PPAR-gamma 19016 P37238 Pparg mouse S133 38507801 PHEEPSNsLMAIECR X -MAP2K1 MEK1 Q02750 human NPAS4 225872 Q8BGD7 Npas4 mouse T427 1869686800 LVCTPPYtPHQPGGC X X -MAP2K1 MEK1 Q02750 human TDP-43 23435 Q13148 TARDBP human T153 63083902 GFGFVRFtEyETQVk RRM_1 X -MAP2K1 MEK1 Q02750 human ERK2 26413 P63085 Mapk1 mouse Y185 447594 HtGFLtEyVAtRWYR Pkinase X X 9106; 4370; 4374; 9101; 4375; 4376; 4377; 3510; 5726; 88569; 13214; 13148; 70235; 9488; 89967; 8544; 14196; 14227; 14095; 14474; 75165; 98168; 33370; 54240; 15892; 45899; 55088; 9524; 69217; 48735 -MAP2K1 MEK1 Q02750 human ERK1 5595 P27361 MAPK3 human T207 3949243 FLtEyVAtRWyrAPE Pkinase X -MAP2K1 MEK1 Q02750 human MLXIP 22877 Q9HAP2 MLXIP human Y222 40556408 IEIVIREyHKWRTYF X -MAP2K1 MEK1 Q02750 human ERK1 26417 Q63844 Mapk3 mouse T203 447542 HDHtGFLtEyVAtRW Pkinase X 9106; 4370; 4374; 9101; 4375; 4376; 4377; 3510; 5726; 88569; 13214; 13148; 70235; 9488; 89967; 8544; 14196; 14227; 14095; 14474; 75165; 98168; 33370; 54240; 15892; 45899; 55088; 9524; 69217; 48735 -MAP2K1 MEK1 Q02750 human ERK2 26413 P63085 Mapk1 mouse T183 447593 HDHtGFLtEyVAtRW Pkinase X X 9106; 4370; 4374; 9101; 4375; 4376; 4377; 3510; 5726; 88569; 13214; 13148; 70235; 9488; 89967; 8544; 14196; 14227; 14095; 14474; 75165; 98168; 33370; 54240; 15892; 45899; 55088; 9524; 69217; 48735 -MAP2K1 MEK1 Q02750 human ERK2 116590 P63086 Mapk1 rat T183 447593 HDHtGFLtEyVAtRW Pkinase X 9106; 4370; 4374; 9101; 4375; 4376; 4377; 3510; 5726; 88569; 13214; 13148; 70235; 9488; 89967; 8544; 14196; 14227; 14095; 14474; 75165; 98168; 33370; 54240; 15892; 45899; 55088; 9524; 69217; 48735 -MAP2K1 MEK1 Q02750 human GSK3B 2932 P49841 GSK3B human Y216 448569 RGEPNVsyICsRyyR Pkinase X X -MAP2K1 MEK1 Q02750 human K8 3856 P05787 KRT8 human S74 448539 tVNQsLLsPLVLEVD Keratin_2_head X -MAP2K1 MEK1 Q02750 human RAF1 110157 Q99N57 Raf1 mouse S338 447742 RPRGQRDssyyWEIE X 9427 -MAP2K1 MEK1 Q02750 human TDP-43 23435 Q13148 TARDBP human Y155 464438 GFVRFtEyETQVkVM RRM_1 X -MAP2K1 MEK1 Q02750 human NPAS4 225872 Q8BGD7 Npas4 mouse T423 1871095704 LSKDLVCtPPYtPHQ X X -MAP2K1 MEK1 Q02750 human NPAS4 225872 Q8BGD7 Npas4 mouse S615 1871095701 GLLtPEAsPVKQSFF X X -MAP2K1 MEK1 Q02750 human ERK1 50689 P21708 Mapk3 rat T203 447542 HDHTGFLtEyVAtRW Pkinase X 9106; 4370; 4374; 9101; 4375; 4376; 4377; 3510; 5726; 88569; 13214; 13148; 70235; 9488; 89967; 8544; 14196; 14227; 14095; 14474; 75165; 98168; 33370; 54240; 15892; 45899; 55088; 9524; 69217; 48735 -MAP2K1 MEK1 Q02750 human ERK1 26417 Q63844 Mapk3 mouse Y205 447543 HtGFLtEyVAtRWyR Pkinase X 9106; 4370; 4374; 9101; 4375; 4376; 4377; 3510; 5726; 88569; 13214; 13148; 70235; 9488; 89967; 8544; 14196; 14227; 14095; 14474; 75165; 98168; 33370; 54240; 15892; 45899; 55088; 9524; 69217; 48735 -MAP2K1 MEK1 Q02750 human MACC1 346389 Q6ZN28 MACC1 human Y793 1874020222 KPAYDFLyTWSAHYG X -MAP2K1 MEK1 Q02750 human MACC1 346389 Q6ZN28 MACC1 human Y673 1874020218 VLADVLGySHLSLED X -MAP2K1 MEK1 Q02750 human ERK2 5594 P28482 MAPK1 human T185 447593 HDHtGFLtEyVAtRW Pkinase X X 9106; 4370; 4374; 9101; 4375; 4376; 4377; 3510; 5726; 88569; 13214; 13148; 70235; 9488; 89967; 8544; 14196; 14227; 14095; 14474; 75165; 98168; 33370; 54240; 15892; 45899; 55088; 9524; 69217; 48735 -MAP2K1 MEK1 Q02750 human ERK1 5595 P27361 MAPK3 human Y210 459504 EyVAtRWyrAPEIML Pkinase X -MAP2K1 MEK1 Q02750 human NPAS4 225872 Q8BGD7 Npas4 mouse T611 1871095703 LVPEGLLtPEAsPVK X X -MAP2K1 MEK1 Q02750 human ERK2 116590 P63086 Mapk1 rat Y185 447594 HtGFLtEyVAtRWYR Pkinase X 9106; 4370; 4374; 9101; 4375; 4376; 4377; 3510; 5726; 88569; 13214; 13148; 70235; 9488; 89967; 8544; 14196; 14227; 14095; 14474; 75165; 98168; 33370; 54240; 15892; 45899; 55088; 9524; 69217; 48735 -MAP2K1 MEK1 Q02750 human MACC1 346389 Q6ZN28 MACC1 human Y695 1874020220 KESEKVSyVIKKLKE X -MAP2K1 MEK1 Q02750 human ERK1 5595 P27361 MAPK3 human T202 447542 HDHtGFLtEyVAtRW Pkinase X X 9106; 4370; 4374; 9101; 4375; 4376; 4377; 3510; 5726; 88569; 13214; 13148; 70235; 9488; 89967; 8544; 14196; 14227; 14095; 14474; 75165; 98168; 33370; 54240; 15892; 45899; 55088; 9524; 69217; 48735 -MAP2K1 MEK1 Q02750 human TAL1 6886 P17542 TAL1 human S122 450663 DGRMVQLsPPALAAP X -MAP2K1 MEK1 Q02750 human ARRB2 25388 P29067 Arrb2 rat T383 455373 EFDTNYAtDDDIVFE X X -MAP2K1 MEK1 Q02750 human ERK2 5594 P28482 MAPK1 human Y187 447594 HtGFLtEyVAtRWyr Pkinase X X 9106; 4370; 4374; 9101; 4375; 4376; 4377; 3510; 5726; 88569; 13214; 13148; 70235; 9488; 89967; 8544; 14196; 14227; 14095; 14474; 75165; 98168; 33370; 54240; 15892; 45899; 55088; 9524; 69217; 48735 -MAP2K1 MEK1 Q02750 human HSF1 3297 Q00613 HSF1 human S326 455484 ssVDtLLsPTALIDs Vert_HS_TF X X -MAP2K1 MEK1 Q02750 human Ku70 2547 P12956 XRCC6 human S78 1875071708 YISKIIssDRDLLAV Ku_N X -MAP2K1 MEK1 Q02750 human RAF1 5894 P04049 RAF1 human S338 447742 RPRGQRDssyyWEIE X 9427 -MAP2K1 MEK1 Q02750 human ERK1 5595 P27361 MAPK3 human Y204 447543 HtGFLtEyVAtRWyr Pkinase X X 9106; 4370; 4374; 9101; 4375; 4376; 4377; 3510; 5726; 88569; 13214; 13148; 70235; 9488; 89967; 8544; 14196; 14227; 14095; 14474; 75165; 98168; 33370; 54240; 15892; 45899; 55088; 9524; 69217; 48735 -MAP2K1 MEK1 Q02750 human NPAS4 225872 Q8BGD7 Npas4 mouse S577 1871095700 LYEKLPPsPSsPGNG X X -MAP2K1 MEK1 Q02750 human PR 5241 P06401 PGR human S294 447987 APMAPGRsPLATTVM Prog_receptor X 13736 -Map3k8 Cot Q07174 mouse PLCB3 18797 P51432 Plcb3 mouse S537 448450 TSLEPQKsLGEEsLS X 2481; 29021 -Pak1 PAK1 P35465 rat Merlin 25744 Q63648 Nf2 rat S514 448282 DTDMKRLsMEIEKEK ERM_C X 9163; 13281 -Pak1 PAK1 P35465 rat PAK1 29431 P35465 Pak1 rat S21 448174 APPMRNTsTMIGAGS X -Pak1 PAK1 P35465 rat SHOT1 292139 A0MZ67 Shtn1 rat S101 4761847 NKTLKRIsMLYMAKL X -Pak1 PAK1 P35465 rat SYN1 24949 P09951 Syn1 rat S9 448378 NYLRRRLsDSNFMAN Synapsin_N X 2311; 67605 -Pak1 PAK1 P35465 rat SYN1 24949 P09951 Syn1 rat S603 450236 AGPIRQAsQAGPGPR X 88246 -Pak1 PAK1 P35465 rat PAK1 29431 P35465 Pak1 rat T422 448177 PEQSKRstMVGTPYW Pkinase X X -Pak1 PAK1 P35465 rat PAK1 29431 P35465 Pak1 rat S198 448172 PRPEHTKsVYTRsVI X -Pak1 PAK1 P35465 rat SYN1 281510 P17599 SYN1 cow S551 451574 PATRPPAsPsPQRQA X -Pak1 PAK1 P35465 rat SHOT1 292139 A0MZ67 Shtn1 rat S249 485709 QNKLKRQsHLLLQSS X -Pak1 PAK1 P35465 rat PAK1 29431 P35465 Pak1 rat S203 448173 TKsVYTRsVIEPLPV X -Pak1 PAK1 P35465 rat MEK1 170851 Q01986 Map2k1 rat S298 448284 RtPGRPLsSYGMDSR Pkinase X 9128; 98195 -Pak1 PAK1 P35465 rat SYN1 281510 P17599 SYN1 cow S605 450236 AGPTRQAsQAGPMPR X -Pak1 PAK1 P35465 rat SYN1 281510 P17599 SYN1 cow S9 448378 NYLRRRLsDSNFMAN Synapsin_N X -Pak1 PAK1 P35465 rat PRKD1 85421 Q9WTQ1 Prkd1 rat S203 449896 GVRRRRLsNVsLTGL X -Pak1 PAK1 P35465 rat PAK1 29431 P35465 Pak1 rat S144 448170 SNSQKYMsFTDKsAE X -Pak1 PAK1 P35465 rat HACE1 57531 Q8IYU2 HACE1 human S385 10940679 LMKNKRDsTEITsIL X -GRK4 GRK4 P32298 human GRK4 2868 P32298 GRK4 human S10 41590803 LENIVANsLLLkARQ X -GRK4 GRK4 P32298 human GRK4 2868 P32298 GRK4 human S430 41590801 MLLtKNPsKRLGCRG Pkinase X -GRK4 GRK4 P32298 human BKR2 624 P30411 BDKRB2 human S366 447663 EPIQMENsMGTLRTs X -GRK4 GRK4 P32298 human BKR2 624 P30411 BDKRB2 human S375 447665 GTLRTsIsVERQIHk X -GRK4 GRK4 P32298 human DRD1 24316 P18901 Drd1 rat T428 458339 sVILDYDtDVsLEKI X -GRK4 GRK4 P32298 human GRK4 2868 P32298 GRK4 human S419 41590806 KFSEDAKsICRMLLt Pkinase X -GRK4 GRK4 P32298 human GRK4 2868 P32298 GRK4 human S139 41590800 GLKEENPsKKAFEEC RGS X -GRK4 GRK4 P32298 human GRK4 2868 P32298 GRK4 human T426 41590804 sICRMLLtKNPsKRL Pkinase X -GRK4 GRK4 P32298 human GRK4 2868 P32298 GRK4 human S249 41590802 VQsRFVVsLAYAYEt Pkinase X -GRK4 GRK4 P32298 human GRK4 2868 P32298 GRK4 human S244 41590807 RILEKVQsRFVVsLA Pkinase X -GRK4 GRK4 P32298 human BKR2 624 P30411 BDKRB2 human S373 447664 sMGTLRTsIsVERQI X -GRK4 GRK4 P32298 human GRK4 2868 P32298 GRK4 human S485 23111438 VLDIEQFsVVKGIYL X -GRK4 GRK4 P32298 human GRK4 2868 P32298 GRK4 human T256 41590805 sLAYAYEtKDALCLV Pkinase X -GRK4 GRK4 P32298 human DRD1 24316 P18901 Drd1 rat S431 458340 LDYDtDVsLEKIQPV X -Myo3b MYO3B Q1EG27 mouse MYO3B 329421 Q1EG27 Myo3b mouse T178 36841906 sTRLRRNtSVGTPFW Pkinase X -Myo3b MYO3B Q1EG27 mouse MYO3B 329421 Q1EG27 Myo3b mouse S171 36841905 GVSAQLTsTRLRRNt Pkinase X -Myo3b MYO3B Q1EG27 mouse MYO3B 329421 Q1EG27 Myo3b mouse T918 36841908 TTNMKRQtMASYFRY Myosin_head X -Myo3b MYO3B Q1EG27 mouse MYO3B 329421 Q1EG27 Myo3b mouse S887 36841907 KITASSRsLPPHFSA Myosin_head X -Myo3b MYO3B Q1EG27 mouse MYO3B 329421 Q1EG27 Myo3b mouse T1246 36841909 YYNQLNGtLEYQGSQ X -SIK2 QIK Q9H0K1 human STX16 228960 Q8BVI5 Stx16 mouse T7 4754210 _MATRRLtDAFLLLR X -SIK2 QIK Q9H0K1 human PIK3R1 5295 P27986 PIK3R1 human S154 7445250 stLYRtQsSSNLAEL RhoGAP X -SIK2 QIK Q9H0K1 human CDK5R1 8851 Q15078 CDK5R1 human S91 12607404 ENLKKSLsCANLSTF CDK5_activator X X -SIK2 QIK Q9H0K1 human LRP6 4040 O75581 LRP6 human S1490 456289 AILNPPPsPAtERsH X X 2568 -SIK2 QIK Q9H0K1 human TORC3 70461 Q91X84 Crtc3 mouse S162 7101661 SALNRTNsDSALHTS TORC_M X -SIK2 QIK Q9H0K1 human TORC3 70461 Q91X84 Crtc3 mouse S370 1210886 SLRLFsLsNPsLSTT X -SIK2 QIK Q9H0K1 human PIK3R1 5295 P27986 PIK3R1 human S541 57829901 RISEIIDsRRRLEED PI3K_P85_iSH2 X X -SIK2 QIK Q9H0K1 human smMLCK 4638 Q15746 MYLK human S343 468783 PVLQKTSsSITLQAA 23ISL X X -SIK2 QIK Q9H0K1 human TORC3 70461 Q91X84 Crtc3 mouse S62 3203139 LtQyHGGsLPNVSQL TORC_N X -SIK2 QIK Q9H0K1 human LRP6 4040 O75581 LRP6 human S1420 460717 YVVHGPAsVPLGYVP X X -SIK2 QIK Q9H0K1 human IRS1 25467 P35570 Irs1 rat S789 447557 QHLRLSSsSGRLRYT X 2389 -SIK2 QIK Q9H0K1 human QIK 23235 Q9H0K1 SIK2 human S90 25120404 YQVMETKsMLYLVTE Pkinase X -SIK2 QIK Q9H0K1 human TORC2 74343 Q3U182 Crtc2 mouse S171 454622 sALNRtSsDsALHTs TORC_M X X -SIK2 QIK Q9H0K1 human CEP250 11190 Q9BV73 CEP250 human S2392 4728455 AGLHHsLsHsLLAVA X X -SIK2 QIK Q9H0K1 human TORC3 70461 Q91X84 Crtc3 mouse S329 468980 SGLQSsRsNPsIQAT X -SIK2 QIK Q9H0K1 human QIK 23235 Q9H0K1 SIK2 human S343 2150903 RLKSHRssFPVEQRL X -SIK2 QIK Q9H0K1 human HDAC5 10014 Q9UQL6 HDAC5 human S259 447995 FPLRkTAsEPNLKVR X 3443 -SIK2 QIK Q9H0K1 human QIK 23235 Q9H0K1 SIK2 human S358 487501 DGRQRRPstIAEQTV X -SIK2 QIK Q9H0K1 human CEP250 11190 Q9BV73 CEP250 human S2394 4728460 LHHsLsHsLLAVAQA X X -Mapk10 JNK3 Q61831 mouse DLK 26404 Q60700 Map3k12 mouse S533 27447446 RNVPQKLsPHSKRPD X X -Mapk10 JNK3 Q61831 mouse Bcl-2 596 P10415 BCL2 human T74 448632 ARtsPLQtPAAPGAA X -Mapk10 JNK3 Q61831 mouse JIP3 iso2 30957 Q9ESN9-2 Mapk8ip3 mouse T255 458343 SVPSAAVtPLNESLQ X -Mapk10 JNK3 Q61831 mouse DLK 26404 Q60700 Map3k12 mouse T43 4727854 CtPEKDLtPTQCVLR X X -Mapk10 JNK3 Q61831 mouse Bcl-2 596 P10415 BCL2 human S87 448396 AAAGPALsPVPPVVH X -Mapk10 JNK3 Q61831 mouse BIM 12125 O54918 Bcl2l11 mouse S65 449330 GPLAPPAsPGPFATR X 4581; 4585 -Mapk10 JNK3 Q61831 mouse JIP3 iso2 30957 Q9ESN9-2 Mapk8ip3 mouse T244 458342 TTGTKSNtPTSSVPS X -Mapk10 JNK3 Q61831 mouse Bcl-2 596 P10415 BCL2 human S70 448395 RDPVARtsPLQtPAA X 2834; 2827 -Mapk10 JNK3 Q61831 mouse Jun 16476 P05627 Jun mouse S63 447686 kNsDLLtsPDVGLLK Jun X 5464; 9261; 2361; 97721; 91952 -Mapk10 JNK3 Q61831 mouse MCL1 17210 P97287 Mcl1 mouse S102 1172400 SAAAAIVsPEEELDG X -Mapk10 JNK3 Q61831 mouse MCL1 17210 P97287 Mcl1 mouse T144 455375 ADGsLPStPPPPEEE X 4579 -Mapk10 JNK3 Q61831 mouse KIF5C 16574 P28738 Kif5c mouse S176 54436200 CTERFVSsPEEVMDV Kinesin X -Mapk10 JNK3 Q61831 mouse Bcl-2 596 P10415 BCL2 human T56 448655 FSSQPGHtPHPAASR X 2875 -Mapk10 JNK3 Q61831 mouse JIP3 iso2 30957 Q9ESN9-2 Mapk8ip3 mouse T234 458341 GQSSAAAtPSTTGTK X -MAP2K3 MKK3 P46734 human P38D 26415 Q9Z1B7 Mapk13 mouse Y182 454935 TDTEMtGyVVTRWYR Pkinase X 9211; 9215; 4551; 9216; 4552; 4631; 4511; 4092; 9219; 24678; 8632; 6908; 41768; 51255; 14594; 14598; 62979 -MAP2K3 MKK3 P46734 human P38A 26416 P47811 Mapk14 mouse T180 447970 RHtDDEMtGyVAtRW Pkinase X 9211; 9215; 4551; 9216; 4552; 4631; 4511; 4092; 9219; 24678; 8632; 6908; 41768; 51255; 14594; 14598; 62979 -MAP2K3 MKK3 P46734 human P38A 81649 P70618 Mapk14 rat T180 447970 RHTDDEMtGyVATRW Pkinase X 9211; 9215; 4551; 9216; 4552; 4631; 4511; 4092; 9219; 24678; 8632; 6908; 41768; 51255; 14594; 14598; 62979 -MAP2K3 MKK3 P46734 human P38A 81649 P70618 Mapk14 rat Y182 447971 TDDEMtGyVATRWYR Pkinase X 9211; 9215; 4551; 9216; 4552; 4631; 4511; 4092; 9219; 24678; 8632; 6908; 41768; 51255; 14594; 14598; 62979 -MAP2K3 MKK3 P46734 human MKK3 5606 P46734 MAP2K3 human S218 448276 IsGyLVDsVAKtMDA Pkinase X 9231; 9236; 12280 -MAP2K3 MKK3 P46734 human P38D 5603 O15264 MAPK13 human T180 4787496 RHADAEMtGyVVtRW Pkinase X 9211; 9215; 4551; 9216; 4552; 4631; 4511; 4092; 9219; 24678; 8632; 6908; 41768; 51255; 14594; 14598; 62979 -MAP2K3 MKK3 P46734 human P38A 1432 Q16539 MAPK14 human T180 447970 RHtDDEMtGyVAtRW Pkinase X X 9211; 9215; 4551; 9216; 4552; 4631; 4511; 4092; 9219; 24678; 8632; 6908; 41768; 51255; 14594; 14598; 62979 -MAP2K3 MKK3 P46734 human P38A 26416 P47811 Mapk14 mouse Y182 447971 tDDEMtGyVAtRWYR Pkinase X 9211; 9215; 4551; 9216; 4552; 4631; 4511; 4092; 9219; 24678; 8632; 6908; 41768; 51255; 14594; 14598; 62979 -MAP2K3 MKK3 P46734 human P38D 26415 Q9Z1B7 Mapk13 mouse T180 4787496 RHTDTEMtGyVVTRW Pkinase X 9211; 9215; 4551; 9216; 4552; 4631; 4511; 4092; 9219; 24678; 8632; 6908; 41768; 51255; 14594; 14598; 62979 -MAP2K3 MKK3 P46734 human P38D 5603 O15264 MAPK13 human Y182 454935 ADAEMtGyVVtRWYR Pkinase X 9211; 9215; 4551; 9216; 4552; 4631; 4511; 4092; 9219; 24678; 8632; 6908; 41768; 51255; 14594; 14598; 62979 -MAP2K3 MKK3 P46734 human MKK3 5606 P46734 MAP2K3 human T222 448277 LVDsVAKtMDAGCKP Pkinase X -MAP2K3 MKK3 P46734 human P38A 1432 Q16539 MAPK14 human Y182 447971 tDDEMtGyVAtRWYR Pkinase X X 9211; 9215; 4551; 9216; 4552; 4631; 4511; 4092; 9219; 24678; 8632; 6908; 41768; 51255; 14594; 14598; 62979 - ERK1 no information NRF2 4780 Q16236 NFE2L2 human S408 10292700 GDMVQPLsPSQGQST X - ERK1 no information NRF2 4780 Q16236 NFE2L2 human S577 10292702 DEDGkPysPSEYSLQ X - ERK1 no information NRF2 4780 Q16236 NFE2L2 human S215 10292704 VETTMVPsPEAKLTE X -CDK6 CDK6 Q00534 human Rb 5925 P06400 RB1 human S780 447978 strPPtLsPIPHIPr Rb_C X X 9307; 3590; 8180 -CDK6 CDK6 Q00534 human TFEB 7942 P19484 TFEB human S467 4785142 KASsRRssFsMEEGD DUF3371 X -CDK6 CDK6 Q00534 human Rb-like 2 5934 Q08999 RBL2 human T401 449723 SKALRIStPLtGVRY X -CDK6 CDK6 Q00534 human TFEB 7942 P19484 TFEB human T331 3181634 RVHGLPttsPsGMNM DUF3371 X -CDK6 CDK6 Q00534 human FOXM1 2305 Q08050 FOXM1 human T510 22648003 EDSSQsPtPRPKKSy X -CDK6 CDK6 Q00534 human AML1 iso8 861 Q01196-8 RUNX1 human S276 454399 DTRQIQPsPPWSYDQ X -CDK6 CDK6 Q00534 human AML1 iso8 861 Q01196-8 RUNX1 human S48 452744 TPPSTALsPGKMSEA X -CDK6 CDK6 Q00534 human FOXM1 2305 Q08050 FOXM1 human T611 451437 ETLPISstPSkSVLP X -CDK6 CDK6 Q00534 human TSC2 7249 P49815 TSC2 human S1452 3191272 LPSssPRsPsGLrPr X -CDK6 CDK6 Q00534 human FOXM1 2305 Q08050 FOXM1 human S508 22648001 sWEDSSQsPtPRPKK X -CDK6 CDK6 Q00534 human EGLN2 112398 Q96KS0 EGLN2 human S130 31088285 EDGGDAPsPsKRPWA X -CDK6 CDK6 Q00534 human AML1 iso8 861 Q01196-8 RUNX1 human T300 454403 sPSVHPAtPIsPGRA X -CDK6 CDK6 Q00534 human PKM iso2 5315 P14618-2 PKM human S37 476070 MCRLDIDsPPITARN X -CDK6 CDK6 Q00534 human FOXM1 2305 Q08050 FOXM1 human S522 8146040 KSySGLRsPtRCVSE X -CDK6 CDK6 Q00534 human PTPN2 19255 Q06180 Ptpn2 mouse S304 451134 LsPICDHsQNRVMVE X X -CDK6 CDK6 Q00534 human Rb 5925 P06400 RB1 human T826 447984 LPtPtkMtPRsRILV Rb_C X -CDK6 CDK6 Q00534 human Rb 19645 P13405 Rb1 mouse S804 448717 IyIsPLksPyKIsEG Rb_C X 9308; 8974; 4277; 40283; 8957; 8516; 11917; 41359; 75864 -CDK6 CDK6 Q00534 human AML1 iso8 861 Q01196-8 RUNX1 human S424 1308915 SMVGGERsPPRILPP RunxI X -CDK6 CDK6 Q00534 human Rb-like 2 5934 Q08999 RBL2 human S672 448254 tLyDRySsPPAsTtR X -CDK6 CDK6 Q00534 human Rb 5925 P06400 RB1 human S795 447979 sPykFPssPLrIPGG Rb_C X 9301 -CDK6 CDK6 Q00534 human CELF1 10658 Q92879 CELF1 human S302 3347301 TSSGSsPsSSSSNSV X -CDK6 CDK6 Q00534 human Rb 5925 P06400 RB1 human T252 449821 PINGsPRtPRRGQNR X X -CDK6 CDK6 Q00534 human PFKFB3 5209 Q16875 PFKFB3 human S467 468406 NsVtPLAsPEPtKKP X -CDK6 CDK6 Q00534 human Rb 5925 P06400 RB1 human S788 450022 PIPHIPrsPykFPss Rb_C X -CDK6 CDK6 Q00534 human FOXM1 2305 Q08050 FOXM1 human T627 3194576 tPEsWRLtPPAKVGG X -CDK6 CDK6 Q00534 human Rb 5925 P06400 RB1 human S249 447975 AVIPINGsPRtPRRG X X -CDK6 CDK6 Q00534 human PFKFB3 5209 Q16875 PFKFB3 human T463 468407 LMRRNsVtPLAsPEP X -CDK6 CDK6 Q00534 human Rb-like 2 5934 Q08999 RBL2 human S1035 449738 NMDAPPLsPyPFVRt X -CDK6 CDK6 Q00534 human NPM1 4869 P06748 NPM1 human T199 448515 VkKsIrDtPAkNAQK X 3541; 75984 -CDK6 CDK6 Q00534 human Rb 5925 P06400 RB1 human S612 447977 MyLsPVRsPKKKGsT X -CDK6 CDK6 Q00534 human FOXM1 2305 Q08050 FOXM1 human S704 449265 IDVPKPGsPEPQVSG X -CDK6 CDK6 Q00534 human TFEB 7942 P19484 TFEB human S142 3181628 AGNsAPNsPMAMLHI MITF_TFEB_C_3_N X X -CDK6 CDK6 Q00534 human AML1 iso8 861 Q01196-8 RUNX1 human S303 454401 VHPAtPIsPGRASGM X -CDK6 CDK6 Q00534 human p27Kip1 1027 P46527 CDKN1B human T187 447875 NAGsVEQtPKKPGLR X -CDK6 CDK6 Q00534 human PKM 5315 P14618 PKM human S37 476070 MCRLDIDsPPItARN X -CDK6 CDK6 Q00534 human PTPN2 19255 Q06180 Ptpn2 mouse S298 3181136 ELsKEDLsPICDHsQ X X -CDK6 CDK6 Q00534 human p21Cip1 1026 P38936 CDKN1A human S130 455618 sGEQAEGsPGGPGDs X -CDK6 CDK6 Q00534 human FOXM1 2305 Q08050 FOXM1 human S489 22648002 PPLEEWPsPAPSFkE X -CDK6 CDK6 Q00534 human TFEB 7942 P19484 TFEB human S114 3181613 HIsPAQGsPkPPPAA MITF_TFEB_C_3_N X -CDK6 CDK6 Q00534 human Rb 19645 P13405 Rb1 mouse S773 447978 STRPPtLsPIPHIPR Rb_C X 9307; 3590; 8180 -CDK6 CDK6 Q00534 human PTP1B 19246 P35821 Ptpn1 mouse S50 447811 RNRyRDVsPFDHSRI Y_phosphatase X X -CDK6 CDK6 Q00534 human PTP1B 19246 P35821 Ptpn1 mouse S205 36133122 VRESGSLsLEHGPIV Y_phosphatase X X -CDK6 CDK6 Q00534 human TFE3 7030 P19532 TFE3 human S246 56653430 PTGSAPNsPMALLTI MITF_TFEB_C_3_N X X -CDK6 CDK6 Q00534 human FLNA 2316 P21333 FLNA human S2152 451357 tRRRRAPsVANVGsH Filamin X 4761 -CDK6 CDK6 Q00534 human HuR 1994 Q15717 ELAVL1 human S202 3197192 LLsQLyHsPArrFGG X X -CDK6 CDK6 Q00534 human Rb 5925 P06400 RB1 human T821 447983 kIsEGLPtPtkMtPR Rb_C X 31433 -CDK6 CDK6 Q00534 human RPRM 56475 Q9NS64 RPRM human S98 15722493 LVKDRRPsKEVEAVV X X -CDK6 CDK6 Q00534 human p27Kip1 1027 P46527 CDKN1B human S10 447874 NVRVSNGsPsLErMD X -CDK6 CDK6 Q00534 human PTPN2 19255 Q06180 Ptpn2 mouse S52 23136003 RNRYRDVsPYDHSRV Y_phosphatase X X -CDK6 CDK6 Q00534 human FOXM1 2305 Q08050 FOXM1 human T600 478080 EVGGPFKtPIkETLP X 14655 -CDK6 CDK6 Q00534 human p53 7157 P04637 TP53 human R249 394791401 CMGGMNRrPILTIIT P53 X -CDK6 CDK6 Q00534 human Rb 5925 P06400 RB1 human S807 447980 PGGNIyIsPLksPyk Rb_C X X 9308; 8974; 4277; 40283; 8957; 8516; 11917; 99274; 41359; 75864; 72443 -CDK6 CDK6 Q00534 human FLNA 2316 P21333 FLNA human S1459 452266 kCsGPGLsPGMVRAN Filamin X -CDK6 CDK6 Q00534 human FOXM1 2305 Q08050 FOXM1 human T620 3194573 SkSVLPRtPEsWRLt X -CDK6 CDK6 Q00534 human AML1 iso8 861 Q01196-8 RUNX1 human S293 454400 QYLGSIAsPSVHPAt X -CDK6 CDK6 Q00534 human TSC2 7249 P49815 TSC2 human S1217 1868502602 MSLENPLsPFSSDIN X -CDK6 CDK6 Q00534 human Rb 5925 P06400 RB1 human S811 448717 IyIsPLksPykIsEG Rb_C X X 9308; 8974; 4277; 40283; 8957; 8516; 11917; 41359; 75864; 63276 -CDK6 CDK6 Q00534 human FOXM1 2305 Q08050 FOXM1 human S451 7320841 LLFGEGFsPLLPVQT X -CDK6 CDK6 Q00534 human PTPN2 19255 Q06180 Ptpn2 mouse T261 10997733 YRMGLIQtPDQLRFS Y_phosphatase X X -CDK6 CDK6 Q00534 human Rb 19645 P13405 Rb1 mouse S800 447980 PGGNIyIsPLksPyK Rb_C X 9308; 8974; 4277; 40283; 8957; 8516; 11917; 41359; 75864; 72443 -CDK8 CDK8 P49336 human STAT1 6772 P42224 STAT1 human S727 447753 TDNLLPMsPEEFDEV STAT1_TAZ2bind X X 9177; 8826; 62390 -CDK8 CDK8 P49336 human OSBPL3 iso3 71720 D3Z194 Osbpl3 mouse S264 6209027 IQGGAFEsPKKEKRP X -CDK8 CDK8 P49336 human SMAD1 4086 Q15797 SMAD1 human S195 451174 PNSSYPNsPGSSSSt X -CDK8 CDK8 P49336 human SMAD1 4086 Q15797 SMAD1 human S187 451173 NSHPFPHsPNSSYPN X -CDK8 CDK8 P49336 human E2F1 1869 Q01094 E2F1 human S375 3193946 PVDEDRLsPLVAADS X X -CDK8 CDK8 P49336 human H3 8350 P68431 H3C1 human S10 455676 tkQtArkstGGkAPr Histone X X 9701; 9711; 9606; 3465; 3642; 3377; 3475; 3458; 5764; 47398; 8481; 8552; 53348; 29237; 66065; 43185; 64522; 52725 -CDK8 CDK8 P49336 human SMAD1 4086 Q15797 SMAD1 human S206 451175 SSStYPHsPTSSDPG X X 9553; 5753 -CDK8 CDK8 P49336 human CCNH 902 P51946 CCNH human S304 12521707 yEDDDyVsKKsKHEE X X -CDK8 CDK8 P49336 human SMAD1 4086 Q15797 SMAD1 human S214 451176 PTSSDPGsPFQMPAD X -CDK8 CDK8 P49336 human SMAD3 4088 P84022 SMAD3 human T179 451177 PQSNIPEtPPPGYLS X X -CDK8 CDK8 P49336 human SMAD3 4088 P84022 SMAD3 human S213 451180 NLsPNPMsPAHNNLD X -CDK8 CDK8 P49336 human STAT3 20848 P42227 Stat3 mouse S727 448191 NtIDLPMsPRTLDSL X 9134; 9136; 34911; 94994; 49081; 58978; 87544; 71958; 50804 -CDK8 CDK8 P49336 human STAT5A 20850 P42230 Stat5a mouse S725 448749 TYMDQAPsPVVCPQP X -CDK8 CDK8 P49336 human Notch 1 4851 P46531 NOTCH1 human S2513 35483201 EHPFLtPsPEsPDQW X X -CDK8 CDK8 P49336 human Notch 1 4851 P46531 NOTCH1 human T2511 483083 VPEHPFLtPsPEsPD X X -CDK8 CDK8 P49336 human SMAD3 4088 P84022 SMAD3 human S208 451179 DAGsPNLsPNPMsPA X -CDK8 CDK8 P49336 human CCNH 902 P51946 CCNH human S5 456230 ___MYHNsSQkRHWT X X -CDK8 CDK8 P49336 human Notch 1 4851 P46531 NOTCH1 human S2516 35483202 FLtPsPEsPDQWsss X -CDK8 CDK8 P49336 human STAT1 20846 P42225 Stat1 mouse S727 447753 tDNLLPMsPEEFDEM STAT1_TAZ2bind X 9177; 8826; 62390 -Prkcb PKCB P68403 rat TUBA1B 10376 P68363 TUBA1B human T253 31889716 GALNVDLtEFQtNLV X X -Prkcb PKCB P68403 rat PLCB3 29322 Q99JE6 Plcb3 rat S1105 448448 LDRKRNNsISEAKTR PLC-beta_C X 2484 -Prkcb PKCB P68403 rat PKCB 25023 P68403 Prkcb rat T642 447897 tRQPVELtPTDKLFI Pkinase_C X -Prkcb PKCB P68403 rat RKIP 29542 P31044 Pebp1 rat S153 448755 RGkFkVEsFRKKYHL PBP X -Prkcb PKCB P68403 rat ATF-2 1386 P15336 ATF2 human S367 451442 ERNRAAAsRCRQKRk bZIP_1 X -Prkcb PKCB P68403 rat PKCB 25023 P68403 Prkcb rat T314 447894 RAkIGQGtkAPEEkT X -Prkcb PKCB P68403 rat PKCB 25023 P68403 Prkcb rat S661 448672 QNEFAGFsYTNPEFV Pkinase_C X 9371 -Prkcb PKCB P68403 rat Kv3.1 25327 P25122 Kcnc1 rat S503 464642 LEINRADsKLNGEVA X -Prkcb PKCB P68403 rat PKCB 25023 P68403 Prkcb rat T324 447895 PEEkTANtISkFDNN X -Prkcb PKCB P68403 rat ATF-2 1386 P15336 ATF2 human S340 451441 tPQtQSTsGRRRRAA X -Prkcb PKCB P68403 rat PKCB 25023 P68403 Prkcb rat T17 447893 PsEGEEstVRFARKG X -Prkcb PKCB P68403 rat PKCB 25023 P68403 Prkcb rat T635 1869073012 sNFDKEFtRQPVELt Pkinase_C X -Prkcb PKCB P68403 rat NOX1 114243 Q9WV87 Nox1 rat T429 36552501 RAHNKLKtQKIYFYW NAD_binding_6 X X -Prkcb PKCB P68403 rat CD5 921 P06127 CD5 human T434 450129 MsFHRNHtAtVRsHA X -Prkcb PKCB P68403 rat VDR 7421 P11473 VDR human S51 451285 CKGFFRRsMKRKALF zf-C4 X -Prkcb PKCB P68403 rat PKCB 25023 P68403 Prkcb rat S16 447892 PPsEGEEstVRFARK X -Prkcb PKCB P68403 rat G-gamma 12 14701 Q9DAS9 Gng12 mouse S2 447876 ______MssktAstN X -Prkcb PKCB P68403 rat TH 25085 P04177 Th rat S31 448544 KQAEAVtsPRFIGRR TOH_N X 3370; 13041 -Prkcb PKCB P68403 rat GLUT1 24778 P11167 Slc2a1 rat S226 10827359 NEENRAKsVLKKLRG Sugar_tr X -Prkcb PKCB P68403 rat CD5 921 P06127 CD5 human T436 450130 FHRNHtAtVRsHAEN X -PTK2 FAK Q05397 human CDCP1 64866 Q9H5V8 CDCP1 human Y734 451434 KDNDsHVyAVIEDTM X 9050 -PTK2 FAK Q05397 human PXN 395832 P49024 PXN chicken Y118 448604 AsEEEHVysFPNKQK Paxillin X 69363 -PTK2 FAK Q05397 human PIK3R2 5296 O00459 PIK3R2 human Y464 449572 sREyDQLyEEytRTS PI3K_P85_iSH2 X X 17366; 62098; 81913 -PTK2 FAK Q05397 human CTNNB1 1499 P35222 CTNNB1 human Y142 449044 AVVNLINyQDDAELA X -PTK2 FAK Q05397 human ITGB7 3695 P26010 ITGB7 human Y753 469601 YRLSVEIyDRREySR Integrin_b_cyt X -PTK2 FAK Q05397 human NANOG 79923 Q9H9S0 NANOG human Y35 25240301 ICGPEENyPSLQMSS X X -PTK2 FAK Q05397 human beclin 1 8678 Q14457 BECN1 human Y233 477225 EAQyQREysEFkRQQ APG6_N X -PTK2 FAK Q05397 human ACTN1 87 P12814 ACTN1 human Y12 450200 DsQQtNDyMQPEEDW X X -PTK2 FAK Q05397 human PXN 5829 P49023 PXN human Y118 448604 VGEEEHVysFPNkQk Paxillin X 2541; 69363 -PTK2 FAK Q05397 human Cortactin 13043 Q60598 Cttn mouse Y421 447702 RPPssPIyEDAAPFK X 4569 -PTK2 FAK Q05397 human P130Cas 9564 P56945 BCAR1 human Y165 448722 PSPATDLyQVPPGPG X 4015 -PTK2 FAK Q05397 human Akt1 207 P31749 AKT1 human S473 447855 RPHFPQFsysAsGtA Pkinase_C X 9271; 3787; 4060; 4051; 5102; 4058; 2336; 2337; 4075; 4070; 5012; 4071; 92982; 5315; 9563; 9018; 12694; 52240; 11962; 15116; 88106; 26580; 68035; 31957; 23430; 20235 -PTK2 FAK Q05397 human PXN 360820 Q66H76 Pxn rat Y31 448785 FLSEEPPySYPTGNH X -PTK2 FAK Q05397 human LAT iso2 27040 O43561-2 LAT human Y171 448004 SMESIDDyVNVPESG LAT X X -PTK2 FAK Q05397 human FAK 5747 Q05397 PTK2 human Y577 447890 yMEDstyyKAsKGKL PK_Tyr_Ser-Thr X 3281 -PTK2 FAK Q05397 human GIT1 28964 Q9Y2X7 GIT1 human Y321 15702200 FLPVNPEySATRNQG X -PTK2 FAK Q05397 human PMCA4 iso6 493 P23634-6 ATP2B4 human Y1176 449557 LDGEVTPyANTNNNA X -PTK2 FAK Q05397 human FAK 5747 Q05397 PTK2 human Y407 447888 IIDEEDtytMPSTRD X -PTK2 FAK Q05397 human TRIO 7204 O75962 TRIO human Y2796 11263902 KDNFDsFySEVAELG Pkinase X -PTK2 FAK Q05397 human P130Cas 9564 P56945 BCAR1 human Y410 448720 GVVDsGVyAVPPPAE X 4011 -PTK2 FAK Q05397 human GRB7 2886 Q14451 GRB7 human Y338 7965101 AAFRLFKyGVQLyKN PH X -PTK2 FAK Q05397 human FAK 14083 P34152 Ptk2 mouse Y397 447887 sVsEtDDyAEIIDEE X 3283; 8556 -PTK2 FAK Q05397 human ITGB7 3695 P26010 ITGB7 human Y758 469602 EIyDRREySRFEkEQ Integrin_b_cyt X -PTK2 FAK Q05397 human HDAC5 10014 Q9UQL6 HDAC5 human Y642 1869973801 PLQPLQVyQAPLSLA X X -PTK2 FAK Q05397 human Claudin-11 5010 O75508 CLDN11 human Y191 478785 AFGENRFyyTAGsss X -PTK2 FAK Q05397 human FAK 5747 Q05397 PTK2 human Y397 447887 sVsEtDDyAEIIDEE X X 3283; 8556 -PTK2 FAK Q05397 human endophilin A2 6455 Q99961 SH3GL1 human Y315 450745 QPSCKALyDFEPEND SH3_1 X X -PTK2 FAK Q05397 human RAC1 5879 P63000 RAC1 human Y64 475227 DTAGQEDyDRLRPLs Ras X -PTK2 FAK Q05397 human TAK1 26409 Q62073 Map3k7 mouse S412 455196 NGQPRRRsIQDLtVT X 9339 -PTK2 FAK Q05397 human Claudin-11 5010 O75508 CLDN11 human Y192 478786 FGENRFyyTAGsssP X -PTK2 FAK Q05397 human Ret 5979 P07949 RET human Y905 447627 DVyEEDsyVKRsQGR PK_Tyr_Ser-Thr X X 3221 -PTK2 FAK Q05397 human Cofilin-1 12631 P18760 Cfl1 mouse S3 448444 _____MAsGVAVsDG X 3313; 3311 -PTK2 FAK Q05397 human Cortactin 13043 Q60598 Cttn mouse Y466 447703 TyTSEPVyETTEAPG X -PTK2 FAK Q05397 human FAK 25614 O35346 Ptk2 rat Y397 447887 SVSETDDyAEIIDEE X 3283; 8556 -PTK2 FAK Q05397 human FAK 5747 Q05397 PTK2 human Y576 447889 RyMEDstyyKAsKGK PK_Tyr_Ser-Thr X X 3281 -PTK2 FAK Q05397 human GRB7 2886 Q14451 GRB7 human Y188 7965100 FRKNFAKyELFKssP X -PTK2 FAK Q05397 human NANOG 79923 Q9H9S0 NANOG human Y174 25240300 QKASAPTyPSLYSSY X X -PTK2 FAK Q05397 human TGFBR1 21812 Q64729 Tgfbr1 mouse Y182 7791190 TTLKDLIyDMttsGs TGF_beta_GS X -Map3k14 Nik Q9WUL6 mouse CREB 12912 Q01147 Creb1 mouse S119 448228 EILsRRPsyRkILND pKID X 9187; 9196; 9198; 4095; 14228; 14001; 39561; 80120; 44864; 54960; 95995 -Sik1 SIK Q9R1U5 rat SIK 59329 Q9R1U5 Sik1 rat S186 2560900 PLStWCGsPPYAAPE Pkinase X -ADCK5 ADCK5 Q3MIX3 human SOX9 6662 P48436 SOX9 human S181 456981 YQPRRRKsVKNGQAE X -EPHB3 EphB3 P54753 human EphB3 2049 P54753 EPHB3 human Y614 448275 VyIDPFtyEDPNEAV EphA2_TM X -TYRO3 Tyro3 Q06418 human MLKL 197259 Q8NB16 MLKL human Y376 1868624704 DRVkstAyLSPQELE PK_Tyr_Ser-Thr X X -TYRO3 Tyro3 Q06418 human Akt1 207 P31749 AKT1 human T308 447856 kDGAtMKtFCGtPEy Pkinase X 5106; 2965; 9275; 4056; 5056; 13842; 13038; 43506; 48646; 86758; 80722; 77440; 80556 -MAST3 MAST3 O60307 human ARPP-19 iso2 10776 P56211-2 ARPP19 human S46 465742 KGQKYFDsGDYNMAK Endosulfine X X -Pikfyve PIKFYVE Q9Z1T6 mouse Akt1 207 P31749 AKT1 human S473 447855 RPHFPQFsysAsGtA Pkinase_C X 9271; 3787; 4060; 4051; 5102; 4058; 2336; 2337; 4075; 4070; 5012; 4071; 92982; 5315; 9563; 9018; 12694; 52240; 11962; 15116; 88106; 26580; 68035; 31957; 23430; 20235 -Eif2ak2 PKR Q03963 mouse PKR 19106 Q03963 Eif2ak2 mouse T414 448089 SRtRRTGtLQYMSPE Pkinase X -Eif2ak2 PKR Q03963 mouse IRS1 16367 P35569 Irs1 mouse S307 447558 tEsITAtsPAsMVGG X X 2381 -Eif2ak2 PKR Q03963 mouse eIF2-alpha 13665 Q6ZWX6 Eif2s1 mouse S52 447635 MILLSELsRrrIRSI S1 X X 3597; 9721; 3398; 5199; 53085; 95797 -Epha3 EphA3 P29319 mouse EphA3 13837 P29319 Epha3 mouse Y596 449912 KLPGLRTyVDPHTyE EphA2_TM X -Epha3 EphA3 P29319 mouse EphA3 13837 P29319 Epha3 mouse Y602 449913 TyVDPHTyEDPTQAV EphA2_TM X -Epha3 EphA3 P29319 mouse EphA3 13837 P29319 Epha3 mouse Y779 448910 EDDPEAAyttRGGKI PK_Tyr_Ser-Thr X 8793; 8862 -PCK1 PCK1 P35558 human INSIG2 51141 Q9Y5U4 INSIG2 human S151 1868515112 LWWTFDRsRSGFGLG INSIG X X -PCK1 PCK1 P35558 human INSIG1 3638 O15503 INSIG1 human S207 1868515111 LWWTFDRsRsGLGLG INSIG X X -Camk2a CAMK2A P11798 mouse phosducin 25343 P20942 Pdc rat S36 10431702 WRKFKLEsEDGDSIP Phosducin X -Camk2a CAMK2A P11798 mouse RYR2 6262 Q92736 RYR2 human S2814 458801 IsQTSQVsVDAAHGY X -Camk2a CAMK2A P11798 mouse GluR1 14799 P23818 Gria1 mouse S849 448565 FCLIPQQsINEAIRt X X 75574 -Camk2a CAMK2A P11798 mouse DRP1 74006 Q8K1M6 Dnm1l mouse S622 454690 PIPIMPAsPQKGHAV X 3455; 4494; 63940 -Camk2a CAMK2A P11798 mouse SCN5A 20271 Q9JJV9 Scn5a mouse S571 27281507 PWPLRRPsTQGQPGF Na_trans_cytopl X -Camk2a CAMK2A P11798 mouse GABBR1 54393 Q9WV18 Gabbr1 mouse S867 15167000 ITRGEWQsEAQDtMK X -Camk2a CAMK2A P11798 mouse DAT 6531 Q01959 SLC6A3 human S13 451138 CsVGLMssVVAPAKE X -Camk2a CAMK2A P11798 mouse phosducin 25343 P20942 Pdc rat S106 10431701 QDMHQKLsFGPRYGF Phosducin X -Camk2a CAMK2A P11798 mouse CAMK2A 12322 P11798 Camk2a mouse T305 448802 kLkGAILttMLAtRN X -Camk2a CAMK2A P11798 mouse KIF17 16559 Q99PW8 Kif17 mouse S1029 1720900 SKAKRKKsKNSFGGE X X -Camk2a CAMK2A P11798 mouse HOMER1 26556 Q9Z2Y3 Homer1 mouse S117 51633300 ARLAKEKsQEKMELT X -Camk2a CAMK2A P11798 mouse Vimentin 22352 P20152 Vim mouse S83 451816 GVRLLQDsVdFsLAD Filament_head X 3878; 12569 -Camk2a CAMK2A P11798 mouse ADCY3 104111 Q8VHH7 Adcy3 mouse S1077 452063 NVASRMEsTGVMGNI Guanylate_cyc X -Camk2a CAMK2A P11798 mouse FosB 14282 P13346 Fosb mouse T149 35530404 PRRPREEtLTPEEEE X -Camk2a CAMK2A P11798 mouse NFL 18039 P08551 Nefl mouse S58 457405 LsVRRsyssSSGsLM Filament_head X -Camk2a CAMK2A P11798 mouse CREB iso1 81646 P15337-1 Creb1 rat S133 448228 EILsRRPsYRkILND pKID X X 9187; 9196; 9198; 4095; 14228; 14001; 39561; 80120; 44864; 54960; 95995 -Camk2a CAMK2A P11798 mouse MYBPC3 17868 O70468 Mybpc3 mouse S410 30324206 GsKYIFEsVGAkRTL I-set X -Camk2a CAMK2A P11798 mouse MYBPC3 17868 O70468 Mybpc3 mouse S47 4699355 VRWQRDGsDItANDK I-set X -Camk2a CAMK2A P11798 mouse MYO5A 17918 Q99104 Myo5a mouse S1650 480053 GLRKRtssIADEGty X -Camk2a CAMK2A P11798 mouse MECP2 29386 Q00566 Mecp2 rat S421 470075 EKMPRAGsLESDGCP X -Camk2a CAMK2A P11798 mouse PPP1R3A 100009140 Q00756 RG1 rabbit S48 449320 PQPSRRGsESSEEVY X X -Camk2a CAMK2A P11798 mouse ANO1 101772 Q8BHY3 Ano1 mouse S673 288031701 YLKLRRQsPSDREEY Anoctamin X -Camk2a CAMK2A P11798 mouse PLB 18821 P61014 Pln mouse T17 448115 SAIRRAstIEMPQQA Phospholamban X X 8496 -Camk2a CAMK2A P11798 mouse DAT 6531 Q01959 SLC6A3 human S4 454428 ____MsKskCsVGLM X -Camk2a CAMK2A P11798 mouse SYN1 iso1 20964 O88935-1 Syn1 mouse S605 450236 AGPTRQAsQAGPGPR X -Camk2a CAMK2A P11798 mouse PLB 18821 P61014 Pln mouse S16 448114 RSAIRRAstIEMPQQ Phospholamban X 8496 -Camk2a CAMK2A P11798 mouse CREB iso1 81646 P15337-1 Creb1 rat S142 448547 RkILNDLssDAPGVP pKID X X -Camk2a CAMK2A P11798 mouse DAT 6531 Q01959 SLC6A3 human S12 451137 kCsVGLMssVVAPAK X -Camk2a CAMK2A P11798 mouse DAT 6531 Q01959 SLC6A3 human S2 451135 ______MsKskCsVG X -Camk2a CAMK2A P11798 mouse SERCA2 29693 P11507 Atp2a2 rat S38 448740 KLKERWGsNELPAEE Cation_ATPase_N X -Camk2a CAMK2A P11798 mouse MYBPC3 17868 O70468 Mybpc3 mouse S210 23252009 QHLQLHDsyDRASKV I-set X -Camk2a CAMK2A P11798 mouse MYBPC3 17868 O70468 Mybpc3 mouse S25 30324201 SAEVTAGsAAVFEAE I-set X -Camk2a CAMK2A P11798 mouse CAMK2A 12322 P11798 Camk2a mouse T286 447797 sCMHRQEtVDCLkkF X X 12716 -Camk2a CAMK2A P11798 mouse MYBPC3 17868 O70468 Mybpc3 mouse S282 471080 AGAGRRtsDsHEDAG X -Camk2a CAMK2A P11798 mouse ITGB1 16412 P09055 Itgb1 mouse T788 448600 PIyksAVttVVNPky Integrin_b_cyt X -Camk2a CAMK2A P11798 mouse gp130 16195 Q00560 Il6st mouse S780 448180 QVFSRsEstQPLLDs X X -Camk2a CAMK2A P11798 mouse PTPRA 19262 P18052 Ptpra mouse S204 447612 PLLARsPstNRKYPP X -Camk2a CAMK2A P11798 mouse MCU 215999 Q3UMR5 Mcu mouse S91 27259017 VISVRLPsRRERCQF X -Camk2a CAMK2A P11798 mouse MYBPC3 17868 O70468 Mybpc3 mouse T50 30324202 QRDGsDItANDKYGL I-set X -Camk2a CAMK2A P11798 mouse HOMER2 26557 Q9QWW1 Homer2 mouse S216 51633301 EQWKRQFsICRDEND X -Camk2a CAMK2A P11798 mouse MYBPC3 17868 O70468 Mybpc3 mouse T380 30324205 KGHkIRLtVELADPD I-set X -Camk2a CAMK2A P11798 mouse MYBPC3 17868 O70468 Mybpc3 mouse T290 4699397 DsHEDAGtPDFSsLL X -Camk2a CAMK2A P11798 mouse STX3 iso2 20908 Q64704-2 Stx3 mouse T14 31960301 QLKAKQLtQDDDTDE X -Camk2a CAMK2A P11798 mouse phosducin 25343 P20942 Pdc rat S73 451205 ERMSRKMsIQEYELI Phosducin X -Camk2a CAMK2A P11798 mouse PEA-15 18611 Q62048 Pea15 mouse S116 450281 KDIIRQPsEEEIIKL X X -Camk2a CAMK2A P11798 mouse CREM 12916 P27699 Crem mouse S133 448412 EILSRRPsYRKILNE pKID X 4095; 14228; 14001 -Camk2a CAMK2A P11798 mouse phosducin 25343 P20942 Pdc rat S6 10431700 __MEEAAsQSLEEDF Phosducin X -Camk2a CAMK2A P11798 mouse GluR1 14799 P23818 Gria1 mouse T858 3362100 NEAIRtstLPRNsGA X -Camk2a CAMK2A P11798 mouse FosB 14282 P13346 Fosb mouse S27 465535 SAESQYLsSVDSFGS X -Camk2a CAMK2A P11798 mouse phosducin 25343 P20942 Pdc rat S54 454888 KEILRQMsSPQSRDD Phosducin X -Camk2a CAMK2A P11798 mouse ITGB1 16412 P09055 Itgb1 mouse T789 447709 IyksAVttVVNPkyE Integrin_b_cyt X -Camk2a CAMK2A P11798 mouse MYBPC3 17868 O70468 Mybpc3 mouse S302 471081 sLLKKRDsFRRDskL X X -Camk2a CAMK2A P11798 mouse DAT 6531 Q01959 SLC6A3 human S7 451136 _MsKskCsVGLMssV X -Camk2a CAMK2A P11798 mouse PTPRA 19262 P18052 Ptpra mouse S180 447611 QAGsHSNsFRLSNGR X -Camk2a CAMK2A P11798 mouse RYR2 20191 E9Q401 Ryr2 mouse S2813 458801 IsQtsQVsIDAAHGY X X -Camk2a CAMK2A P11798 mouse MYBPC3 17868 O70468 Mybpc3 mouse S307 2846505 RDsFRRDskLEAPAE X -Camk2a CAMK2A P11798 mouse STMN1 16765 P54227 Stmn1 mouse S16 448554 KELEKRAsGQAFELI Stathmin X 3353 -Camk2a CAMK2A P11798 mouse MYBPC3 17868 O70468 Mybpc3 mouse S105 17660717 APPEkAEsEVAPGAP X -Camk2a CAMK2A P11798 mouse CACNA1C 12288 Q01815 Cacna1c mouse S1545 467228 VACKRLVsMNMPLNS GPHH X -Camk2a CAMK2A P11798 mouse CACNA1C 12288 Q01815 Cacna1c mouse S1487 460572 DYLTRDWsILGPHHL Ion_trans X -Camk2a CAMK2A P11798 mouse MYH9 25745 Q62812 Myh9 rat T1940 452194 RRIVRKGtGDCsDEE X -Camk2a CAMK2A P11798 mouse NMDAR2B 14812 Q01097 Grin2b mouse S1303 450171 NKLRRQHsyDtFVDL NMDAR2_C X 20274; 71335 -Camk2a CAMK2A P11798 mouse NSDDR 747 Q9Y4D2 DAGLA human S782 27807805 APLATMEsLSDTESL X -Camk2a CAMK2A P11798 mouse MYBPC3 17868 O70468 Mybpc3 mouse S273 471079 RsAFRRtsLAGAGRR X -Camk2a CAMK2A P11798 mouse CAMK2A 12322 P11798 Camk2a mouse T306 449596 LkGAILttMLAtRNF X -Camk2a CAMK2A P11798 mouse NSDDR 747 Q9Y4D2 DAGLA human S808 27807806 RSIRGsPsLHAVLER X -Camk2a CAMK2A P11798 mouse FAK 14083 P34152 Ptk2 mouse S843 447963 DVRLsRGsIDREDGS X -RPS6KA1 p90RSK Q15418 human TERF2IP 54386 Q9NYB0 TERF2IP human S205 471278 GDAPVsPssQkLKRK X X -RPS6KA1 p90RSK Q15418 human AS160 9882 O60343 TBC1D4 human S318 455925 EFRsRCssVtGVQRR PID X 8619 -RPS6KA1 p90RSK Q15418 human NHE1 6548 P19634 SLC9A1 human S703 448347 MsRARIGsDPLAyEP X X -RPS6KA1 p90RSK Q15418 human KIBRA 23286 Q8IX03 WWC1 human S947 453630 CRLNRsDsDSSTLSK X X -RPS6KA1 p90RSK Q15418 human NDRG2 57447 Q9UN36 NDRG2 human S350 454251 RsRsRtLsQssEsGt X -RPS6KA1 p90RSK Q15418 human VASP 7408 P50552 VASP human T278 448381 LARRRKAtQVGEktP X X -RPS6KA1 p90RSK Q15418 human p90RSK 6195 Q15418 RPS6KA1 human K335 1881518211 KLYRREIkPPFKPAV X -RPS6KA1 p90RSK Q15418 human CDC25B 994 P30305 CDC25B human T355 3189697 NkRRRsVtPPEEQQE M-inducer_phosp X X -RPS6KA1 p90RSK Q15418 human p90RSK 81771 Q63531 Rps6ka1 rat S380 447990 HQLFRGFsFVATGLM Pkinase_C X 9341; 9335; 13575; 11989; 12032; 75266; 93317; 13397; 13588 -RPS6KA1 p90RSK Q15418 human REPS1 85021 Q96D71 REPS1 human S709 478670 PVRRRLksEDELRPE X X 12005 -RPS6KA1 p90RSK Q15418 human CDC25C 995 P30307 CDC25C human S247 30280700 kVKKkYFsGQGkLRK M-inducer_phosp X -RPS6KA1 p90RSK Q15418 human RIOK2 55781 Q9BVS4 RIOK2 human S483 7446950 QYRTRtLsItssGsA X X -RPS6KA1 p90RSK Q15418 human Nur77 15370 P12813 Nr4a1 mouse S354 447942 GRRGRLPsKPKQPPD X 5095 -RPS6KA1 p90RSK Q15418 human Raptor 57521 Q8N122 RPTOR human S721 4206802 tPrLrsVssyGNIRA X X -RPS6KA1 p90RSK Q15418 human SENP2 75826 Q91ZX6 Senp2 mouse T35 4769095 KRRRssstLFsTAVD X -RPS6KA1 p90RSK Q15418 human EEF2K 29904 O00418 EEF2K human S366 447827 sPQVRtLsGSRPPLL X X 3691 -RPS6KA1 p90RSK Q15418 human Mad1 4084 Q05195 MXD1 human S145 2807903 IERIRMDsIGSTVSS X X -RPS6KA1 p90RSK Q15418 human YB-1 4904 P67809 YBX1 human S102 455636 NPRKyLrsVGDGEtV CSD X X 2900 -RPS6KA1 p90RSK Q15418 human p90RSK 6195 Q15418 RPS6KA1 human S380 447990 HQLFRGFsFVAtGLM Pkinase_C X 9341; 9335; 13575; 11989; 12032; 75266; 93317; 13397; 13588 -RPS6KA1 p90RSK Q15418 human PDCD4 27250 Q53EL6 PDCD4 human S457 458382 RGRKRFVsEGDGGRL X X -RPS6KA1 p90RSK Q15418 human SOS1 6654 Q07889 SOS1 human S1134 483244 PHGPRsAsVssISLT X -RPS6KA1 p90RSK Q15418 human L-plastin 3936 P13796 LCP1 human S5 450852 ___MARGsVsDEEMM X X -RPS6KA1 p90RSK Q15418 human GAB2 14389 Q9Z1S8 Gab2 mouse S620 15410336 PsPHRKPstSsVtsD X -RPS6KA1 p90RSK Q15418 human SOS1 6654 Q07889 SOS1 human S1161 9413177 PPRRRPEsAPAEssP X -RPS6KA1 p90RSK Q15418 human Kv4.3 65195 Q62897 Kcnd3 rat S535 3681504 YPSTRSPsLSSHSGL DUF3399 X X -RPS6KA1 p90RSK Q15418 human BAD 12015 Q61337 Bad mouse S112 447860 ETRsRHssyPAGtEE Bcl-2_BAD X X 9291; 5284; 9296; 5193; 11865; 94223 -RPS6KA1 p90RSK Q15418 human p90RSK 81771 Q63531 Rps6ka1 rat S221 447988 DHEKKAYsFCGTVEY Pkinase X -RPS6KA1 p90RSK Q15418 human DAPK1 1612 P53355 DAPK1 human S289 457379 QALSRKAsAVNMEkF X -RPS6KA1 p90RSK Q15418 human METTL1 4234 Q9UBP6 METTL1 human S27 3627513 YYRQrAHsNPMADHT X X -RPS6KA1 p90RSK Q15418 human TSC2 24855 P49816 Tsc2 rat T1466 448546 GLRPRGYtISDSAPS X 3617; 3611 -RPS6KA1 p90RSK Q15418 human OSTF1 26578 Q92882 OSTF1 human S202 456078 TDAVRtLsNAEDyLD X X -RPS6KA1 p90RSK Q15418 human p90RSK 6195 Q15418 RPS6KA1 human K110 1881518209 VRDRVRTkMERDILA X -RPS6KA1 p90RSK Q15418 human CDC25A 993 P30304 CDC25A human S295 25286643 TKrRKsMsGASPkES M-inducer_phosp X X -RPS6KA1 p90RSK Q15418 human AS160 9882 O60343 TBC1D4 human S570 455923 AKRsLtssLENIFsr X -RPS6KA1 p90RSK Q15418 human EIF4B 75705 Q8BGD9 Eif4b mouse S422 451290 RERsRtGsEssQtGA X 3591 -RPS6KA1 p90RSK Q15418 human EphA2 1969 P29317 EPHA2 human S897 1244153 RVsIRLPstsGsEGV X X 16662; 6347 -RPS6KA1 p90RSK Q15418 human EIF4B 1975 P23588 EIF4B human S425 456897 sRtGsEssQtGtstt X -RPS6KA1 p90RSK Q15418 human ITGB4 3691 P16144 ITGB4 human S1364 451655 PSGsQRPsVSDDTGC X -RPS6KA1 p90RSK Q15418 human Fos 2353 P01100 FOS human S362 448481 AAAHRKGssSNEPSS X -RPS6KA1 p90RSK Q15418 human KIBRA 23286 Q8IX03 WWC1 human T929 3205626 stIIRsKtFsPGPQS X X -RPS6KA1 p90RSK Q15418 human IkB-alpha 4792 P25963 NFKBIA human S32 448203 LLDDRHDsGLDsMkD X 5210; 2859; 9246; 5209 -RPS6KA1 p90RSK Q15418 human MITF iso8 17342 Q08874-8 Mitf mouse S409 450265 KTSSRRSsMSAEETE DUF3371 X -RPS6KA1 p90RSK Q15418 human APAF 317 O14727 APAF1 human S268 23003805 LLTTRDksVTDsVMG NB-ARC X X -RPS6KA1 p90RSK Q15418 human CDC25B 994 P30305 CDC25B human S353 452008 VQNkRRRsVtPPEEQ M-inducer_phosp X X -RPS6KA1 p90RSK Q15418 human BAD 12015 Q61337 Bad mouse S155 447863 GRELRRMsDEFEGsF Bcl-2_BAD X 9297 -RPS6KA1 p90RSK Q15418 human UBR5 51366 O95071 UBR5 human S2483 480595 ENRKRHGssRsVVDM X X -RPS6KA1 p90RSK Q15418 human ERK5 23939 Q9WVS8 Mapk7 mouse S496 455518 SRLRDGPsAPLEAPE X -RPS6KA1 p90RSK Q15418 human ERK5 5598 Q13164 MAPK7 human S496 455518 SRLRDGPsAPLEAPE X -RPS6KA1 p90RSK Q15418 human BAD 572 Q92934 BAD human S75 447860 EIRsRHssyPAGtED Bcl-2_BAD X X 9291; 5284; 9296; 5193; 11865; 94223 -RPS6KA1 p90RSK Q15418 human p90RSK 81771 Q63531 Rps6ka1 rat S732 447991 RRVRKLPsTTL____ X -RPS6KA1 p90RSK Q15418 human DLC1 58834 Q63744 Dlc1 rat S330 458383 VTRTRSLsTCNKRVG X -RPS6KA1 p90RSK Q15418 human GAB2 14389 Q9Z1S8 Gab2 mouse S160 448382 LLRERKSsAPSHSsQ X 3884 -RPS6KA1 p90RSK Q15418 human p90RSK 6195 Q15418 RPS6KA1 human K421 1881518210 FSDGYVVkETIGVGS X -RPS6KA1 p90RSK Q15418 human Raptor 57521 Q8N122 RPTOR human S719 3205932 PCtPrLrsVssyGNI X X -RPS6KA1 p90RSK Q15418 human CREB 1385 P16220 CREB1 human S119 448228 EILsRRPsyRkILND pKID X X 9187; 9196; 9198; 4095; 14228; 14001; 39561; 80120; 44864; 54960; 95995 -RPS6KA1 p90RSK Q15418 human Kv4.3 65195 Q62897 Kcnd3 rat S569 455338 LPATRLRsMQELSTI X X -RPS6KA1 p90RSK Q15418 human CdGAP 57514 Q2M1Z3 ARHGAP31 human S1106 4694057 KGKNRPSsLNLDPAI X -RPS6KA1 p90RSK Q15418 human GSK3B 2932 P49841 GSK3B human S9 449111 SGRPRttsFAEsCkP X X 9336; 9331; 9327; 9323; 9322; 9325; 5558; 8566; 79774; 8466; 25462; 14026; 14332; 14310; 14630 -RPS6KA1 p90RSK Q15418 human NDRG2 57447 Q9UN36 NDRG2 human S332 451010 LsRsRtAsLtsAAsV X -RPS6KA1 p90RSK Q15418 human RANBP3 8498 Q9H6Z4 RANBP3 human S126 460735 VKRERtssLtQFPPs X X 9380 -RPS6KA1 p90RSK Q15418 human AS160 9882 O60343 TBC1D4 human S751 455924 EGRKRtsstCsNEsL X -RPS6KA1 p90RSK Q15418 human MAGI1 14924 Q6RHR9 Magi1 mouse S733 3896422 QPLERKDsQNssQHs MAGI_u5 X X -RPS6KA1 p90RSK Q15418 human capicua 23152 Q96RK0 CIC human S301 478739 EtRERsMsEtGtAAA X X -RPS6KA1 p90RSK Q15418 human DEPTOR 64798 Q8TB45 DEPTOR human S287 4723848 sMssCGssGyFsssP X X -RPS6KA1 p90RSK Q15418 human UBR5 51366 O95071 UBR5 human T637 3952394 PYKRRRstPAPKEEE X -RPS6KA1 p90RSK Q15418 human AS160 9882 O60343 TBC1D4 human S341 455922 QPRRRHAsAPsHVQP PID X -RPS6KA1 p90RSK Q15418 human TSC2 7249 P49815 TSC2 human S1798 454016 GQRKRLIssVEDFTE X -RPS6KA1 p90RSK Q15418 human TSC2 24855 P49816 Tsc2 rat S939 448501 KFRARSTsLNERPKS X 3615 -RPS6KA1 p90RSK Q15418 human SENP2 75826 Q91ZX6 Senp2 mouse T368 40499300 TEDLFEFtEDMEKEI X -RPS6KA1 p90RSK Q15418 human ER-alpha 2099 P03372 ESR1 human S167 448102 GGRERLAsTNDkGSM Oest_recep X X 64508; 42101 -RPS6KA1 p90RSK Q15418 human CARHSP1 23589 Q9Y2V2 CARHSP1 human S52 453062 tRRtrtFsAtVRAsQ X -RPS6KA1 p90RSK Q15418 human NHERF 9368 O14745 NHERF1 human T156 3864004 ELRPRLCtMKKGPsG PDZ X X -RPS6KA1 p90RSK Q15418 human K17 16667 Q9QWL7 Krt17 mouse S44 464291 AGsCRLGsASGLGSA X -RPS6KA1 p90RSK Q15418 human S6 6194 P62753 RPS6 human S236 448093 AKRRRLssLRAstsK X X 5006; 4856; 4857; 4858; 4851; 4803; 2211; 3945; 3985; 5316; 4854; 8520; 48319; 40643; 9865; 38573; 14733; 27036; 34411; 62016; 62788; 81736; 97935; 99457; 15448 -RPS6KA1 p90RSK Q15418 human Chk1 1111 O14757 CHEK1 human S280 447831 AKRPRVtsGGVsEsP X X 2347 -RPS6KA1 p90RSK Q15418 human MITF iso9 4286 O75030-9 MITF human S409 450265 KTSsRRSsMSMEETE DUF3371 X X -RPS6KA1 p90RSK Q15418 human NFkB-p65 5970 Q04206 RELA human S276 447798 sMQLRRPsDRELsEP RHD_dimer X -RPS6KA1 p90RSK Q15418 human DEPTOR 64798 Q8TB45 DEPTOR human S286 21697912 ssMssCGssGyFsss X X -RPS6KA1 p90RSK Q15418 human FLNA 2316 P21333 FLNA human S2152 451357 tRRRRAPsVANVGsH Filamin X X 4761 -RPS6KA1 p90RSK Q15418 human AS160 9882 O60343 TBC1D4 human T642 455921 QFRRRAHtFsHPPss X 4288; 8881 -RPS6KA1 p90RSK Q15418 human CCT2 10576 P78371 CCT2 human S260 472352 GsRVRVDstAkVAEI Cpn60_TCP1 X X -RPS6KA1 p90RSK Q15418 human AS160 9882 O60343 TBC1D4 human T568 486326 NKAKRsLtssLENIF X -RPS6KA1 p90RSK Q15418 human APAF 317 O14727 APAF1 human S357 23003807 FKRIRKSsSYDYEAL NB-ARC X X -RPS6KA1 p90RSK Q15418 human AS160 9882 O60343 TBC1D4 human S588 455920 RMRGRLGsVDsFERs X 8730 -RPS6KA1 p90RSK Q15418 human UBR5 51366 O95071 UBR5 human S1227 21214703 DCKLKRTsPTAYCDC X -RPS6KA1 p90RSK Q15418 human SENP2 75826 Q91ZX6 Senp2 mouse S38 25753045 RssstLFsTAVDtDE X -RPS6KA1 p90RSK Q15418 human AS160 9882 O60343 TBC1D4 human S666 486327 GRAQGVRsPLLRQSS X -RPS6KA1 p90RSK Q15418 human YB-1 22608 P62960 Ybx1 mouse S100 455636 NPRKyLRsVGDGEtV CSD X 2900 -RPS6KA1 p90RSK Q15418 human PDCD4 27250 Q53EL6 PDCD4 human S76 2588300 RDsGrGDsVsDsGsD X -RPS6KA1 p90RSK Q15418 human GMF-beta 2764 P60983 GMFB human T27 451486 KFRFRKEtNNAAIIM Cofilin_ADF X -RPS6KA1 p90RSK Q15418 human CDC34 997 P49427 CDC34 human T162 59049803 KGkDREYtDIIrkQV UQ_con X X -RPS6KA1 p90RSK Q15418 human MAGI1 9223 Q96QZ7 MAGI1 human S741 3896422 QPLERKDsQNSSQHs MAGI_u5 X -RPS6KA1 p90RSK Q15418 human EIF4B 1975 P23588 EIF4B human S422 451290 RERsRtGsEssQtGt X X 3591 -RPS6KA1 p90RSK Q15418 human S6 6194 P62753 RPS6 human S235 448092 IAKRRRLssLRAsts X X 5006; 4856; 4857; 4858; 4851; 4803; 2211; 3945; 3985; 5316; 4854; 8520; 48319; 40643; 9865; 38573; 14733; 27036; 34411; 62016; 62788; 81736; 97935; 99457; 15448 -RPS6KA1 p90RSK Q15418 human BAD 12015 Q61337 Bad mouse S136 447862 PFRGRsRsAPPNLWA Bcl-2_BAD X 9295; 5286; 4366 -RPS6KA1 p90RSK Q15418 human SENP2 59343 Q9HC62 SENP2 human T369 40499300 TDDLLELtEDMEKEI X -RPS6KA1 p90RSK Q15418 human DEPTOR 64798 Q8TB45 DEPTOR human S291 4723858 CGssGyFsssPtLss X X -RPS6KA1 p90RSK Q15418 human CdGAP 57514 Q2M1Z3 ARHGAP31 human S1178 484822 ALTGRRNsAPVsVsA X -RPS6KA1 p90RSK Q15418 human capicua 23152 Q96RK0 CIC human S173 3209781 PGKRRtQsLsALPKE X X -RPS6KA1 p90RSK Q15418 human CDC25A 993 P30304 CDC25A human S293 449128 GSTKrRKsMsGASPk M-inducer_phosp X X -RPS6KA1 p90RSK Q15418 human Raptor 57521 Q8N122 RPTOR human S722 2314601 PrLrsVssyGNIRAV X X -RPS6KA1 p90RSK Q15418 human GAB2 14389 Q9Z1S8 Gab2 mouse S211 4825112 TENARSAsFSQGTRQ X -EPHA7 EphA7 Q15375 human GLO1 2739 Q04760 GLO1 human Y136 463450 GIAVPDVysACkRFE Glyoxalase X -Braf BRAF F1M9C3 rat MEK1 170851 Q01986 Map2k1 rat S218 448514 VsGQLIDsMANsFVG Pkinase X 9121; 3958; 9154; 86128 -Braf BRAF F1M9C3 rat MEK1 170851 Q01986 Map2k1 rat S222 448513 LIDsMANsFVGTRSY Pkinase X 2338; 9121; 3958; 9154; 16211; 86128; 16780; 75262 -GRK1 GRK1 P28327 cow GRK1 281457 P28327 GRK1 cow S5 2528801 ___MDFGsLEtVVAN X -GRK1 GRK1 P28327 cow GRK1 281457 P28327 GRK1 cow T8 2528800 MDFGsLEtVVANSAF X -GRK1 GRK1 P28327 cow GRK1 281457 P28327 GRK1 cow T489 2530400 QDVGAFstVKGVAFE X X -GRK1 GRK1 P28327 cow GRK1 281457 P28327 GRK1 cow S488 2530401 IQDVGAFstVKGVAF X X -GRK1 GRK1 P28327 cow GRK1 281457 P28327 GRK1 cow S21 456353 AFIAARGsFDASSGP X -PDGFRA PDGFRA P16234 human PDGFRA 5156 P16234 PDGFRA human Y1018 448647 RLSADsGyIIPLPDI X 4547 -PDGFRA PDGFRA P16234 human PDGFRA 5156 P16234 PDGFRA human Y572 448437 IsPDGHEyIyVDPMQ X -PDGFRA PDGFRA P16234 human PDGFRA 5156 P16234 PDGFRA human Y988 450905 RVDSDNAyIGVtyKN X -PDGFRA PDGFRA P16234 human Daple 440193 Q9P219 CCDC88C human Y2025 899136400 PQTVWyEyGCV____ X -PDGFRA PDGFRA P16234 human Src 6714 P12931 SRC human Y419 448234 RLIEDNEytARQGAk PK_Tyr_Ser-Thr X 2101; 6943; 59548; 70926; 78740; 94361; 17320 -PDGFRA PDGFRA P16234 human PDGFRA 5156 P16234 PDGFRA human Y574 448438 PDGHEyIyVDPMQLP X -TAOK1 TAO1 Q7L7X3 human RhoE 390 P61587 RND3 human S210 27933600 KNVKRNKsQRATKRI X X -TAOK1 TAO1 Q7L7X3 human RhoE 390 P61587 RND3 human S218 25307985 QRATKRIsHMPsRPE X -TAOK1 TAO1 Q7L7X3 human TAO1 57551 Q7L7X3 TAOK1 human T440 23150854 RNREHFAtIRtAsLV X -TAOK1 TAO1 Q7L7X3 human LATS1 9113 O95835 LATS1 human T1079 457595 EHAFyEFtFRRFFDD X 8654 -TAOK1 TAO1 Q7L7X3 human TAO1 57551 Q7L7X3 TAOK1 human T443 1880716204 EHFAtIRtAsLVTRQ X -TAOK1 TAO1 Q7L7X3 human RhoE 390 P61587 RND3 human S240 27933601 LRKDKAKsCTVM___ X -TAOK1 TAO1 Q7L7X3 human SEPT7 989 Q16181 SEPTIN7 human T426 476328 EQQNssrtLEKNKKK X -TAOK1 TAO1 Q7L7X3 human TAO1 57551 Q7L7X3 TAOK1 human S181 7321740 SMAsPANsFVGtPyW Pkinase X -GRK2 GRK2 P25098 human Radixin 5962 P35241 RDX human T564 448374 AGRDKyKtLRQIRQG ERM_C X 3141; 3726; 32600 -GRK2 GRK2 P25098 human KOR-3 4987 P41146 OPRL1 human S346 1868135700 LRRDVQVsDRVRsIA X -GRK2 GRK2 P25098 human TRHR 25570 Q01717 Trhr rat S364 1229700 IKEsDRFstELDDIt X -GRK2 GRK2 P25098 human EDNRA 1909 P25101 EDNRA human S391 2911717 LCCCCyQsKsLMtsV X -GRK2 GRK2 P25098 human Ezrin 7430 P15311 EZR human T567 448104 QGRDkyKtLRQIRQG ERM_C X X 3141; 3726; 32600 -GRK2 GRK2 P25098 human ADRB2 154 P07550 ADRB2 human S396 457440 GHQGtVPsDNIDsQG X X -GRK2 GRK2 P25098 human NHE5 6553 Q14940 SLC9A5 human S712 20832301 EEEEsDssEtEKEDD X -GRK2 GRK2 P25098 human DOR-1 18386 P32300 Oprd1 mouse S363 448550 RVtACtPsDGPGGGA X -GRK2 GRK2 P25098 human TRHR 25570 Q01717 Trhr rat S360 1229701 NYsVIKEsDRFstEL X -GRK2 GRK2 P25098 human MOR-1 4988 P35372 OPRM1 human S377 447784 QNtRDHPstANtVDR X 3451 -GRK2 GRK2 P25098 human mAChR M2 1129 P08172 CHRM2 human T287 459103 KEssNDstsVsAVAs 7tm_1 X -GRK2 GRK2 P25098 human H1R 3269 P35367 HRH1 human S398 450937 WKRLRsHsRQyVSGL 7tm_1 X -GRK2 GRK2 P25098 human mAChR M2 1129 P08172 CHRM2 human S294 459112 tsVsAVAsNMRDDEI 7tm_1 X -GRK2 GRK2 P25098 human TUBB3 22152 Q9ERD7 Tubb3 mouse S444 451154 YEDDDEEsEAQGPK_ X -GRK2 GRK2 P25098 human SSTR2 P30680 Sstr2 rat T353 7652102 DKsRLNEttEtQRtL X -GRK2 GRK2 P25098 human RPLP2 140662 P02401 Rplp2 rat S105 454320 KKEEsEEsDDDMGFG Ribosomal_60s X -GRK2 GRK2 P25098 human NPFFR2 10886 Q9Y5X5 NPFFR2 human S520 36533409 LKEttNssEI_____ X -GRK2 GRK2 P25098 human MOR-1 18390 P42866 Oprm1 mouse T376 20727901 NtREHPstANtVDRT X -GRK2 GRK2 P25098 human mAChR M2 1129 P08172 CHRM2 human S288 459104 EssNDstsVsAVAsN 7tm_1 X -GRK2 GRK2 P25098 human ADRA1D 146 P25100 ADRA1D human S334 1424270003 HtFRssLsVRLLKFS 7tm_1 X -GRK2 GRK2 P25098 human Epac1 iso3 10411 O95398-3 RAPGEF3 human S108 54400804 GLGVHSRsQVVGICQ DEP X -GRK2 GRK2 P25098 human mAChR M2 1129 P08172 CHRM2 human S283 459120 QGEEKEssNDstsVs 7tm_1 X -GRK2 GRK2 P25098 human GPBAR1 151306 Q8TDU6 GPBAR1 human S324 1877729206 YHPSsQssVDLDLN_ X -GRK2 GRK2 P25098 human NHE5 6553 Q14940 SLC9A5 human S702 20832300 AVILTVEsEEEEEEs X -GRK2 GRK2 P25098 human GNRHR2 100399755 Q95MG6 LOC100399755 marmoset S339 454394 QELSMDssREEGSRR X -GRK2 GRK2 P25098 human ADRA1D 146 P25100 ADRA1D human S332 1424270006 KGHtFRssLsVRLLK 7tm_1 X -GRK2 GRK2 P25098 human KOR-3 4987 P41146 OPRL1 human S351 1868135701 QVsDRVRsIAKDVAL X -GRK2 GRK2 P25098 human mAChR M2 1129 P08172 CHRM2 human S234 459115 NQDPVsPsLVQGRIV 7tm_1 X -GRK2 GRK2 P25098 human NHE5 6553 Q14940 SLC9A5 human S711 20832303 EEEEEsDssEtEKED X -GRK2 GRK2 P25098 human P38A 1432 Q16539 MAPK14 human T123 471074 IVkCQkLtDDHVQFL Pkinase X X -GRK2 GRK2 P25098 human calsenilin 30818 Q9Y2W7 KCNIP3 human S95 471337 FTkKELQsLYRGFKN X -GRK2 GRK2 P25098 human DOR-1 4985 P41143 OPRD1 human T361 448551 RERVtACtPsDGPGG X -GRK2 GRK2 P25098 human mAChR M2 1129 P08172 CHRM2 human S290 459105 sNDstsVsAVAsNMR 7tm_1 X -GRK2 GRK2 P25098 human SSTR5 6755 P35346 SSTR5 human T333 27724400 GAKDADAtEPRPDRI X -GRK2 GRK2 P25098 human GPBAR1 151306 Q8TDU6 GPBAR1 human S323 1877729204 AYHPSsQssVDLDLN X -GRK2 GRK2 P25098 human ADIPOR1 51094 Q96A54 ADIPOR1 human T24 40263801 AsNREADtVELAELG X -GRK2 GRK2 P25098 human NHE5 6553 Q14940 SLC9A5 human S709 20832304 sEEEEEEsDssEtEK X -GRK2 GRK2 P25098 human ADRB2 11555 P18762 Adrb2 mouse S355 458916 KTYGNGYssNSNGRT X -GRK2 GRK2 P25098 human SSTR2 P30680 Sstr2 rat S341 7652103 GAEDGERsDsKQDKs X -GRK2 GRK2 P25098 human NPFFR2 10886 Q9Y5X5 NPFFR2 human T517 36533412 MEELKEttNssEI__ X -GRK2 GRK2 P25098 human CXCR4 12767 P70658 Cxcr4 mouse S354 12575201 VsTESEsssFHSs__ X -GRK2 GRK2 P25098 human NPFFR2 10886 Q9Y5X5 NPFFR2 human S519 36533407 ELKEttNssEI____ X -GRK2 GRK2 P25098 human Vinculin 22330 Q64727 Vcl mouse S721 3181157 DEAIDtksLLDAsEE Vinculin X -GRK2 GRK2 P25098 human SSTR2 P30680 Sstr2 rat S343 7652105 EDGERsDsKQDKsRL X -GRK2 GRK2 P25098 human IGF1R 3480 P08069 IGF1R human S1278 4271095 EPGFREVsFyySEEN X -GRK2 GRK2 P25098 human NHE5 6553 Q14940 SLC9A5 human T714 20832302 EEsDssEtEKEDDEG X -GRK2 GRK2 P25098 human ADRB2 11555 P18762 Adrb2 mouse S356 458917 TYGNGYssNSNGRTD X -GRK2 GRK2 P25098 human mAChR M2 1129 P08172 CHRM2 human T271 459118 KAPRDPVtENCVQGE 7tm_1 X -GRK2 GRK2 P25098 human SSTR2 P30680 Sstr2 rat T359 12577700 EttEtQRtLLNGDLQ X -GRK2 GRK2 P25098 human mAChR M2 1129 P08172 CHRM2 human S309 459107 tQDENtVstsLGHSK 7tm_1 X -GRK2 GRK2 P25098 human mAChR M2 1129 P08172 CHRM2 human S232 459114 VANQDPVsPsLVQGR 7tm_1 X -GRK2 GRK2 P25098 human mAChR M2 1129 P08172 CHRM2 human T307 459106 EItQDENtVstsLGH 7tm_1 X -GRK2 GRK2 P25098 human Radixin 19684 P26043 Rdx mouse T564 448374 AGRDKYKtLRQIRQG ERM_C X 3141; 3726; 32600 -GRK2 GRK2 P25098 human ADRB2 154 P07550 ADRB2 human S407 457443 DsQGRNCstNDsLL_ X X -GRK2 GRK2 P25098 human ADIPOR1 51094 Q96A54 ADIPOR1 human S7 40263802 _MSSHKGsVVAQGNG X -GRK2 GRK2 P25098 human mAChR M2 1129 P08172 CHRM2 human T302 459113 NMRDDEItQDENtVs 7tm_1 X -GRK2 GRK2 P25098 human TXA2-R iso2 6915 P21731-2 TBXA2R human S357 469629 RLPGSSDsRASASRA X -GRK2 GRK2 P25098 human TRHR 25570 Q01717 Trhr rat S355 1229702 YSVALNYsVIKEsDR X -GRK2 GRK2 P25098 human mAChR M2 1129 P08172 CHRM2 human S282 459119 VQGEEKEssNDstsV 7tm_1 X -GRK2 GRK2 P25098 human FZD6 8323 O60353 FZD6 human S648 1275585104 sVSESARsEGRIsPK X -GRK2 GRK2 P25098 human MOR-1 25601 P33535 Oprm1 rat S375 447784 QNtREHPsTANTVDR X -GRK2 GRK2 P25098 human SNCA 6622 P37840 SNCA human S129 448278 NEAyEMPsEEGyQDy Synuclein X X 23706; 87281 -GRK2 GRK2 P25098 human ADRA1D 146 P25100 ADRA1D human S300 1424270001 KRERGKAsEVVLRIH 7tm_1 X -GRK2 GRK2 P25098 human EDNRA 1909 P25101 EDNRA human S393 2911710 CCCyQsKsLMtsVPM X -GRK2 GRK2 P25098 human DOR-1 4985 P41143 OPRD1 human S363 448550 RVtACtPsDGPGGGA X -GRK2 GRK2 P25098 human TUBB 29214 P69897 Tubb5 rat S420 3146605 SNMNDLVsEYQQYQD X -GRK2 GRK2 P25098 human ADRB2 154 P07550 ADRB2 human S411 457444 RNCstNDsLL_____ X -GRK2 GRK2 P25098 human ADRB2 154 P07550 ADRB2 human S355 458916 KAyGNGyssNGNtGE X -GRK2 GRK2 P25098 human mAChR M2 1129 P08172 CHRM2 human S311 459109 DENtVstsLGHSKDE 7tm_1 X -GRK2 GRK2 P25098 human EDNRA 1909 P25101 EDNRA human S397 2911713 QsKsLMtsVPMNGts X -GRK2 GRK2 P25098 human TXA2-R iso2 6915 P21731-2 TBXA2R human S239 469628 AQQRPRDsEVEMMAQ 7tm_1 X -GRK2 GRK2 P25098 human ADRA1D 146 P25100 ADRA1D human S323 1424270002 DGAHGMRsAKGHtFR 7tm_1 X -GRK2 GRK2 P25098 human GHSR 2693 Q92847 GHSR human S252 1877127904 GDAVVGAsLRDQNHK 7tm_1 X -GRK2 GRK2 P25098 human mAChR M2 1129 P08172 CHRM2 human S250 459116 PNNNNMPssDDGLEH 7tm_1 X -GRK2 GRK2 P25098 human GPBAR1 151306 Q8TDU6 GPBAR1 human S321 1877729202 SIAYHPSsQssVDLD X -GRK2 GRK2 P25098 human KOR-3 4987 P41146 OPRL1 human S363 27150200 VALACKtsETVPRPA X -GRK2 GRK2 P25098 human GNRHR2 100399755 Q95MG6 LOC100399755 marmoset S338 454393 HQELSMDssREEGSR X -GRK2 GRK2 P25098 human mAChR M2 1129 P08172 CHRM2 human S251 459117 NNNNMPssDDGLEHN 7tm_1 X -GRK2 GRK2 P25098 human SSTR2 P30680 Sstr2 rat T356 12577701 RLNEttEtQRtLLNG X -GRK2 GRK2 P25098 human CLTB 1212 P09497 CLTB human S205 25592003 LCDFNPksSkQCKDV Clathrin_lg_ch X X -GRK2 GRK2 P25098 human GPBAR1 151306 Q8TDU6 GPBAR1 human S310 1877729200 WGRASRDsPGPSIAY X -GRK2 GRK2 P25098 human NPFFR2 10886 Q9Y5X5 NPFFR2 human T516 36533408 VMEELKEttNssEI_ X -GRK2 GRK2 P25098 human SSTR2 P30680 Sstr2 rat T354 7652101 KsRLNEttEtQRtLL X -GRK2 GRK2 P25098 human MOR-1 18390 P42866 Oprm1 mouse T370 447785 sARIRQNtREHPstA X -GRK2 GRK2 P25098 human MOR-1 18390 P42866 Oprm1 mouse S375 447784 QNtREHPstANtVDR X 3451 -GRK2 GRK2 P25098 human ADRB2 154 P07550 ADRB2 human S401 457441 VPsDNIDsQGRNCst X -GRK2 GRK2 P25098 human mAChR M2 1129 P08172 CHRM2 human T310 459108 QDENtVstsLGHSKD 7tm_1 X -GRK2 GRK2 P25098 human Moesin 4478 P26038 MSN human T558 447706 LGRDKyKtLRQIRQG ERM_C X 3141; 3726; 32600 -GRK2 GRK2 P25098 human ADRB2 154 P07550 ADRB2 human S356 458917 AyGNGyssNGNtGEQ X -GRK2 GRK2 P25098 human mAChR M2 1129 P08172 CHRM2 human S286 459101 EKEssNDstsVsAVA 7tm_1 X -GRK2 GRK2 P25098 human EDNRA 1909 P25101 EDNRA human T396 2911714 yQsKsLMtsVPMNGt X -GRK2 GRK2 P25098 human CMKOR1 12778 P56485 Ackr3 mouse T352 4709314 DAsRVsEtEysALEQ X -GRK2 GRK2 P25098 human ADRA1D 146 P25100 ADRA1D human S516 1346843003 QLRAKVssLsHKIRA X -GRK2 GRK2 P25098 human SMAD2 4087 Q15796 SMAD2 human T197 25586400 LPPLDDYtHSIPENT X -GRK2 GRK2 P25098 human CMKOR1 12778 P56485 Ackr3 mouse S350 4709309 LIDAsRVsEtEysAL X -GRK2 GRK2 P25098 human ADRB2 154 P07550 ADRB2 human T384 457437 LCEDLPGtEDFVGHQ X -GRK2 GRK2 P25098 human EDNRA 1909 P25101 EDNRA human S404 2911711 sVPMNGtsIQWKNHD X -GRK2 GRK2 P25098 human ADRA1D 146 P25100 ADRA1D human S518 1346843000 RAKVssLsHKIRAGG X -GRK2 GRK2 P25098 human ADIPOR1 51094 Q96A54 ADIPOR1 human S205 1877164900 EKVSRTFsKLDYSGI HlyIII X -GRK2 GRK2 P25098 human CXCR4 12767 P70658 Cxcr4 mouse S353 7997136 sVsTESEsssFHSs_ X -GRK2 GRK2 P25098 human KOR-3 4987 P41146 OPRL1 human T362 1868135702 DVALACKtsETVPRP X -GRK2 GRK2 P25098 human TUBB 29214 P69897 Tubb5 rat T409 3146606 GMDEMEFtEAESNMN X -GRK2 GRK2 P25098 human MOR-1 18390 P42866 Oprm1 mouse T379 20727900 EHPstANtVDRTNHQ X -GRK2 GRK2 P25098 human TRHR 25570 Q01717 Trhr rat T365 465592 KEsDRFstELDDItV X X -GRK2 GRK2 P25098 human RPLP2 140662 P02401 Rplp2 rat S102 454319 KDEKKEEsEEsDDDM Ribosomal_60s X -GRK2 GRK2 P25098 human p53 7157 P04637 TP53 human T55 450685 DDIEQWFtEDPGPDE TAD2 X -GRK2 GRK2 P25098 human ADIPOR1 51094 Q96A54 ADIPOR1 human T53 40263803 PKAEEEQtCPVPQEE X -GRK2 GRK2 P25098 human EDNRA 1909 P25101 EDNRA human T403 2911712 tsVPMNGtsIQWKNH X -NPM/ALK NPM-ALK AAA58698 human PKM 5315 P14618 PKM human Y105 450528 FAsDPILyRPVAVAL PK X X 3827 -NPM/ALK NPM-ALK AAA58698 human NIPA 232679 Q80YV2 Zc3hc1 mouse S353 449745 PIVsRtRsWEsssPV X -NPM/ALK NPM-ALK AAA58698 human MSH2 4436 P43246 MSH2 human Y238 36121371 DFSTkDIyQDLNRLL MutS_II X -NPM/ALK NPM-ALK AAA58698 human WASP 7454 P42768 WAS human Y102 60110900 LLWEQELySQLVYST WH1 X -NPM/ALK NPM-ALK AAA58698 human WASP 7454 P42768 WAS human Y291 447985 AEtsKLIyDFIEDQG PBD X X -NPM/ALK NPM-ALK AAA58698 human STAT1 6772 P42224 STAT1 human Y701 447754 DGPkGtGyIktELIs X 9174; 9167; 5375; 25685; 8062; 8183; 8009; 55603; 7649; 25809; 57216; 45118; 39205; 88845; 88211; 76285; 90145 -MAP3K2 MEKK2 Q9Y2U5 human CTNNB1 1499 P35222 CTNNB1 human S675 457120 QDykKRLsVELtsSL X 9567; 4176; 68076 -MAP3K2 MEKK2 Q9Y2U5 human NDR1 11329 Q15208 STK38 human S91 1869478300 LGLEDFEsLkVIGRG Pkinase X X -MAP3K2 MEKK2 Q9Y2U5 human ANKRD3 72388 Q9ERK0 Ripk4 mouse T184 2926100 SMDGLFGtIAYLPPE Pkinase X X -MAP3K2 MEKK2 Q9Y2U5 human p47phox 17969 Q09014 Ncf1 mouse S208 465580 KRGWVPAsYLEPLDS X X -MAP3K2 MEKK2 Q9Y2U5 human IRF3 3661 Q14653 IRF3 human S173 6370303 PCPQPLRsPsLDNPt X -PRKAB1 AMPKB1 Q9Y478 human SF2 6426 Q07955 SRSF1 human S133 15178110 SGLPPSGsWQDLkDH RRM_1 X -PRKAB1 AMPKB1 Q9Y478 human STIM1 361618 P84903 Stim1 rat S257 468872 GLHRAEQsLHDLQER X -PRKAB1 AMPKB1 Q9Y478 human PDHA1 5160 P08559 PDHA1 human S295 468391 RyHGHsMsDPGVsyR E1_dh X -PRKAB1 AMPKB1 Q9Y478 human PROX1 5629 Q92786 PROX1 human S79 487308 KLLKRANsyEDAMMP X -PRKAB1 AMPKB1 Q9Y478 human SKP2 27401 Q9Z0Z3 Skp2 mouse S256 1296362400 ATLLSSCsRLDELNL X -PRKAB1 AMPKB1 Q9Y478 human Oct1 5451 P14859 POU2F1 human S335 10424763 RFEALNLsFKNMCKL Pou X -PRKAB1 AMPKB1 Q9Y478 human STIM1 361618 P84903 Stim1 rat S521 468874 RDLtHsDsESSLHTS X -PRKAB1 AMPKB1 Q9Y478 human PDHA1 5160 P08559 PDHA1 human S314 1868287349 IQEVRSksDPIMLLk E1_dh X -PRKAB1 AMPKB1 Q9Y478 human STIM1 6786 Q13586 STIM1 human S521 468874 RDLtHsDsEssLHMs X X -PRKAB1 AMPKB1 Q9Y478 human STIM1 6786 Q13586 STIM1 human S257 468872 GLHRAEQsLHDLQER X X -PRKAB1 AMPKB1 Q9Y478 human ARK2N 212163 Q8BH50 Ark2n mouse S67 485212 MELRRDssEsQLAst RNF111_N X X -PRKAB1 AMPKB1 Q9Y478 human SKP2 6502 Q13309 SKP2 human S256 1296362400 QTLLSSCsRLDELNL X -PRKAB1 AMPKB1 Q9Y478 human NEDD4L 23327 Q96PU5 NEDD4L human S795 18963100 VDLKPNGsEIMVTNE HECT X -MAP2K2 MEK2 P36507 human K8 3856 P05787 KRT8 human S74 448539 tVNQsLLsPLVLEVD Keratin_2_head X -MAP2K2 MEK2 P36507 human ERK1 5595 P27361 MAPK3 human T202 447542 HDHtGFLtEyVAtRW Pkinase X X 9106; 4370; 4374; 9101; 4375; 4376; 4377; 3510; 5726; 88569; 13214; 13148; 70235; 9488; 89967; 8544; 14196; 14227; 14095; 14474; 75165; 98168; 33370; 54240; 15892; 45899; 55088; 9524; 69217; 48735 -MAP2K2 MEK2 P36507 human ERK1 5595 P27361 MAPK3 human Y204 447543 HtGFLtEyVAtRWyr Pkinase X X 9106; 4370; 4374; 9101; 4375; 4376; 4377; 3510; 5726; 88569; 13214; 13148; 70235; 9488; 89967; 8544; 14196; 14227; 14095; 14474; 75165; 98168; 33370; 54240; 15892; 45899; 55088; 9524; 69217; 48735 -Pdgfra PDGFRA P26618 mouse PKACA 18747 P05132 Prkaca mouse Y331 15230353 DTSNFDDyEEEEIRV X -Dyrk1a DYRK1A Q61214 mouse GSK3B 56637 Q9WV60 Gsk3b mouse T356 37043704 KLPNGRDtPALFNFT X X -Dyrk1a DYRK1A Q61214 mouse Tau iso8 4137 P10636-8 MAPT human S404 449082 PVVsGDtsPRHLsNV X 35834; 20194; 98523; 91600; 49562 -Dyrk1a DYRK1A Q61214 mouse STXBP1 20910 O08599 Stxbp1 mouse T479 25698802 TyQLSRWtPIIkDIM Sec1 X X -Dyrk1a DYRK1A Q61214 mouse CRY2 12953 Q9R194 Cry2 mouse S557 456803 ALSsGPAsPKRKLEA X X -Dyrk1a DYRK1A Q61214 mouse PSEN1 5663 P49768 PSEN1 human T354 451669 HLGPHRstPEsRAAV Presenilin X -Dyrk1a DYRK1A Q61214 mouse Tau iso8 4137 P10636-8 MAPT human S202 447928 sGyssPGsPGtPGsR X 39357; 30505 -Dyrk1a DYRK1A Q61214 mouse CASP9 12371 Q8C3Q9 Casp9 mouse T163 449563 PEVLRPEtPRPVDIG X -Dyrk1a DYRK1A Q61214 mouse GYS1 100008660 P13834 GYS1 rabbit S641 448237 YRYPRPAsVPPsPSL Glycogen_syn X -JAK3 JAK3 P52333 human STAT5A 6776 P42229 STAT5A human Y694 447767 LAkAVDGyVkPQIkQ X 9365; 9356; 9359; 9351; 4322; 9314; 3939; 40284; 5387; 14603; 66740; 51879; 72712 -JAK3 JAK3 P52333 human JAK1 3716 P23458 JAK1 human Y1034 448451 AIEtDkEyytVkDDR PK_Tyr_Ser-Thr X 3331; 74129; 66245; 32901 -JAK3 JAK3 P52333 human CTNNB1 1499 P35222 CTNNB1 human Y86 447584 VADIDGQyAMTRAQR X X -JAK3 JAK3 P52333 human CTNNB1 1499 P35222 CTNNB1 human Y30 462001 sHWQQQsyLDsGIHs X X -JAK3 JAK3 P52333 human Siglec-10 89790 Q96LC7 SIGLEC10 human Y597 450086 RHstILDyINVVPTA X -JAK3 JAK3 P52333 human CTNNB1 1499 P35222 CTNNB1 human Y64 12170302 VDTsQVLyEWEQGFS X X -JAK3 JAK3 P52333 human HuR 1994 Q15717 ELAVL1 human Y68 29606700 LGyGFVNyVTAkDAE RRM_1 X -JAK3 JAK3 P52333 human JAK3 3718 P52333 JAK3 human Y980 447636 LLPLDkDyyVVREPG PK_Tyr_Ser-Thr X X 5031; 32901 -JAK3 JAK3 P52333 human HuR 1994 Q15717 ELAVL1 human Y200 460123 VALLsQLyHsPArrF X -JAK3 JAK3 P52333 human JAK3 3718 P52333 JAK3 human Y939 2197000 QICkGMEyLGSRRCV PK_Tyr_Ser-Thr X X -JAK3 JAK3 P52333 human PLD2 5338 O14939 PLD2 human Y415 10036101 ALGINSGysKRALML X X -JAK3 JAK3 P52333 human EZH2 2146 Q15910 EZH2 human Y244 59087901 AEELKEKyKELTEQQ PRC2_HTH_1 X -JAK3 JAK3 P52333 human NFAT2 4772 O95644 NFATC1 human Y371 27427900 ADFAPEDySSFQHIR X X -JAK3 JAK3 P52333 human JAK3 3718 P52333 JAK3 human Y785 450358 NSLIsSDyELLSDPT X X -JAK3 JAK3 P52333 human JAK3 3718 P52333 JAK3 human Y904 2197001 SLRLVMEyLPSGCLR PK_Tyr_Ser-Thr X X -JAK3 JAK3 P52333 human Siglec-10 89790 Q96LC7 SIGLEC10 human Y667 450087 ESQEELHyATLNFPG X -JAK3 JAK3 P52333 human SHC1 iso2 6464 P29353-2 SHC1 human Y410 23144113 STTTPGQyVLTGLQS SH2 X -JAK3 JAK3 P52333 human SHC1 iso2 6464 P29353-2 SHC1 human Y448 33664400 SVSHLISyHMDNHLP SH2 X -JAK3 JAK3 P52333 human HuR 1994 Q15717 ELAVL1 human Y63 472818 VAGHSLGyGFVNyVT RRM_1 X -JAK3 JAK3 P52333 human JAK1 3716 P23458 JAK1 human Y1035 448452 IEtDkEyytVkDDRD PK_Tyr_Ser-Thr X 3331; 74129; 66245; 32901 -JAK3 JAK3 P52333 human JAK3 3718 P52333 JAK3 human Y981 447637 LPLDkDyyVVREPGQ PK_Tyr_Ser-Thr X X 5031; 32901 -JAK3 JAK3 P52333 human Siglec-10 89790 Q96LC7 SIGLEC10 human Y691 450088 PKGTQADyAEVKFQ_ X -JAK3 JAK3 P52333 human STAT1 6772 P42224 STAT1 human Y701 447754 DGPkGtGyIktELIs X X 9174; 9167; 5375; 25685; 8062; 8183; 8009; 55603; 7649; 25809; 57216; 45118; 39205; 88845; 88211; 76285; 90145 -PFKFB3 PFKFB3 Q16875 human HER2 2064 P04626 ERBB2 human S1151 3178974 DVRPQPPsPREGPLP X -ITK ITK Q08881 human DEF6 50619 Q9H4E7 DEF6 human Y222 18505504 QDVLKQGyLWkRGHL PH X -ITK ITK Q08881 human Etk 660 P51813 BMX human Y216 449835 SSTSLAQyDSNSKKI X -ITK ITK Q08881 human Siglec-10 89790 Q96LC7 SIGLEC10 human Y597 450086 RHstILDyINVVPTA X -ITK ITK Q08881 human TIM-3 84868 Q8TDQ0 HAVCR2 human Y265 470136 IRSEENIyTIEENVy X -ITK ITK Q08881 human SLP76 3937 Q13094 LCP2 human Y173 456736 FPNsNsMyIDRPPSG X X -ITK ITK Q08881 human TEC 7006 P42680 TEC human Y206 449836 RLERGQEyLILEKND SH3_1 X -ITK ITK Q08881 human DEF6 50619 Q9H4E7 DEF6 human Y210 25687500 SMAIHEVyQELIQDV X -ITK ITK Q08881 human PLCG1 18803 Q62077 Plcg1 mouse Y783 447667 EGRNPGFyVEANPMP X 2821; 14461; 14008; 25678; 88717 -ITK ITK Q08881 human Btk 695 Q06187 BTK human Y223 447485 LKKVVALyDyMPMNA SH3_1 X 5082; 87141; 87457 -ITK ITK Q08881 human ITK 3702 Q08881 ITK human Y180 449834 ETVVIALyDyQtNDP SH3_1 X X -ITK ITK Q08881 human GADS 9402 O75791 GRAP2 human Y45 451894 ELGsQEGyVPkNFID SH3_1 X X -ITK ITK Q08881 human PLCG1 5335 P19174 PLCG1 human Y783 447667 EGRNPGFyVEANPMP X X 2821; 14461; 14008; 25678; 88717 -ITK ITK Q08881 human Siglec-10 89790 Q96LC7 SIGLEC10 human Y667 450087 ESQEELHyATLNFPG X -LMTK2 Lmr2 Q8IWU2 human PPP1CA 5499 P62136 PPP1CA human T320 448686 NPGGRPItPPRNsAK X 2581 -LMTK2 Lmr2 Q8IWU2 human CFTR 1080 P13569 CFTR human S737 449981 EPLERRLsLVPDSEQ CFTR_R X -LMTK2 Lmr2 Q8IWU2 human PPP1CA 100009298 P62139 PPP1CA rabbit T320 448686 NPGGRPItPPRNsAK X -LMTK2 Lmr2 Q8IWU2 human PYGB 5834 P11216 PYGB human S15 456885 sEkRKQIsVRGLAGL X -Csnk1d CK1D Q9DC28 mouse PER2 18627 O54943 Per2 mouse S91 470045 tEAEHNPstSGCSSE X -Csnk1d CK1D Q9DC28 mouse PER2 18627 O54943 Per2 mouse T964 470063 PVtPPAGtVALGRAs X -Csnk1d CK1D Q9DC28 mouse PER2 18627 O54943 Per2 mouse T71 470043 MLVESsNtHPsPDDA X -Csnk1d CK1D Q9DC28 mouse PER2 18627 O54943 Per2 mouse S693 468399 ETVEDMAsGPEsLDG X -Csnk1d CK1D Q9DC28 mouse PER2 18627 O54943 Per2 mouse S776 470019 NtSGLESsWKKTGKN X -Csnk1d CK1D Q9DC28 mouse PER2 18627 O54943 Per2 mouse T1237 470064 PsPGLCDtsEAKEEE X -Csnk1d CK1D Q9DC28 mouse PER2 18627 O54943 Per2 mouse S528 470011 IQtKsHVsHEsGGQK X -Csnk1d CK1D Q9DC28 mouse PER2 18627 O54943 Per2 mouse T800 470055 tRDssEstGsGGPVs X -Csnk1d CK1D Q9DC28 mouse PER2 18627 O54943 Per2 mouse S538 470013 sGGQKEAsVAEMQss X -Csnk1d CK1D Q9DC28 mouse PER2 18627 O54943 Per2 mouse S659 449331 TLPGKAEsVVsLTSQ X X -Csnk1d CK1D Q9DC28 mouse PER2 18627 O54943 Per2 mouse S997 470024 LEEAPEGstGAAGTL X -Csnk1d CK1D Q9DC28 mouse PER2 18627 O54943 Per2 mouse S662 470017 GKAEsVVsLTSQCSY X -Csnk1d CK1D Q9DC28 mouse PER2 18627 O54943 Per2 mouse T92 470046 EAEHNPstSGCSSEQ X -Csnk1d CK1D Q9DC28 mouse PER2 18627 O54943 Per2 mouse T84 470044 DAFRLMMtEAEHNPs X -Csnk1d CK1D Q9DC28 mouse PER2 18627 O54943 Per2 mouse T554 470047 PAQVKAVtTIERDSS X -Csnk1d CK1D Q9DC28 mouse PER2 18627 O54943 Per2 mouse S933 470061 PAHPTLAsEITPAsQ X -Csnk1d CK1D Q9DC28 mouse PER2 18627 O54943 Per2 mouse S531 470012 KsHVsHEsGGQKEAs X -Csnk1d CK1D Q9DC28 mouse PER2 18627 O54943 Per2 mouse S69 470042 LRMLVESsNtHPsPD X -Csnk1d CK1D Q9DC28 mouse PER2 18627 O54943 Per2 mouse S697 468400 DMAsGPEsLDGAAGG X -Csnk1d CK1D Q9DC28 mouse PER2 18627 O54943 Per2 mouse S980 470022 PLFQSRGssPLQLNL X -Csnk1d CK1D Q9DC28 mouse PER2 18627 O54943 Per2 mouse S618 470048 EFPANIPsRKAtVsP X -Csnk1d CK1D Q9DC28 mouse PER2 18627 O54943 Per2 mouse S939 470062 AsEITPAsQAEFPSR X -Csnk1d CK1D Q9DC28 mouse VANGL2 93840 Q91ZD4 Vangl2 mouse S84 18460401 GTSEHsIsHDDLTRI Strabismus X -Csnk1d CK1D Q9DC28 mouse PER2 18627 O54943 Per2 mouse T793 470052 LKSKRVKtRDssEst X -Csnk1d CK1D Q9DC28 mouse PER2 18627 O54943 Per2 mouse T622 470049 NIPsRKAtVsPGLHS X -Csnk1d CK1D Q9DC28 mouse PER2 18627 O54943 Per2 mouse S545 470015 sVAEMQssPPAQVKA X -Csnk1d CK1D Q9DC28 mouse PER2 18627 O54943 Per2 mouse S797 470066 RVKtRDssEstGsGG X -Csnk1d CK1D Q9DC28 mouse PER2 18627 O54943 Per2 mouse T998 470025 EEAPEGstGAAGTLG X -Csnk1d CK1D Q9DC28 mouse PER2 18627 O54943 Per2 mouse S624 470016 PsRKAtVsPGLHSGE X -Csnk1d CK1D Q9DC28 mouse PER2 18627 O54943 Per2 mouse S1238 470065 sPGLCDtsEAKEEEG X -Csnk1d CK1D Q9DC28 mouse PER2 18627 O54943 Per2 mouse S763 470018 ERsRAQAsDRGLRNt X -Csnk1d CK1D Q9DC28 mouse PER2 18627 O54943 Per2 mouse T866 470059 VVAPPAAtHtGFTMP X -Csnk1d CK1D Q9DC28 mouse CTNNB1 12387 Q02248 Ctnnb1 mouse S45 447488 GATtTAPsLsGkGNP X 9565; 9564; 24710; 70034; 19807; 96727; 77605 -Csnk1d CK1D Q9DC28 mouse PER2 18627 O54943 Per2 mouse T868 470060 APPAAtHtGFTMPVV X -Csnk1d CK1D Q9DC28 mouse PER2 18627 O54943 Per2 mouse S544 470014 AsVAEMQssPPAQVK X -Csnk1d CK1D Q9DC28 mouse CTNNB1 12387 Q02248 Ctnnb1 mouse S47 34606438 TtTAPsLsGkGNPEE X -Csnk1d CK1D Q9DC28 mouse PER2 18627 O54943 Per2 mouse S802 470056 DssEstGsGGPVsHR X -Csnk1d CK1D Q9DC28 mouse PER2 18627 O54943 Per2 mouse S796 470053 KRVKtRDssEstGsG X -Csnk1d CK1D Q9DC28 mouse PER2 18627 O54943 Per2 mouse S981 470023 LFQSRGssPLQLNLL X -Csnk1d CK1D Q9DC28 mouse PER2 18627 O54943 Per2 mouse T770 470051 sDRGLRNtSGLESsW X -Csnk1d CK1D Q9DC28 mouse VANGL2 93840 Q91ZD4 Vangl2 mouse S5 18460402 ___MDTEsQysGySY X -Csnk1d CK1D Q9DC28 mouse DNMT1 13433 P13864 Dnmt1 mouse S146 4702934 ksDsDtLsVEtsPss X -Csnk1d CK1D Q9DC28 mouse PER2 18627 O54943 Per2 mouse S525 470010 SGKIQtKsHVsHEsG X -Csnk1d CK1D Q9DC28 mouse PER2 18627 O54943 Per2 mouse T858 470058 GIVSTPGtVVAPPAA X -Csnk1d CK1D Q9DC28 mouse PER2 18627 O54943 Per2 mouse S758 470050 QNYLQERsRAQAsDR X -Csnk1d CK1D Q9DC28 mouse VANGL2 93840 Q91ZD4 Vangl2 mouse S82 18460400 VTGTSEHsIsHDDLT Strabismus X -Csnk1d CK1D Q9DC28 mouse PER2 18627 O54943 Per2 mouse S807 470057 tGsGGPVsHRPPLMG X -Csnk1d CK1D Q9DC28 mouse PER2 18627 O54943 Per2 mouse S799 470054 KtRDssEstGsGGPV X -Csnk1d CK1D Q9DC28 mouse PER2 18627 O54943 Per2 mouse S971 470021 tVALGRAsPPLFQSR X -CLK3 CLK3 P49761 human USP13 8975 Q92995 USP13 human Y708 1868989003 EPLTMPGyGGAASAG UCH X X -CSK CSK P41240 human EEF2 1938 P13639 EEF2 human Y265 457573 kkLWGDryFDPANGk GTP_EFTU X -CSK CSK P41240 human Yes 7525 P07947 YES1 human Y537 447620 FtAtEPQyQPGENL_ X -CSK CSK P41240 human CD45 5788 P08575 PTPRC human Y1218 451644 MVSTFEQyQFLyDVI Y_phosphatase X X -CSK CSK P41240 human Lck 3932 P06239 LCK human Y505 447823 FTAtEGQyQPQP___ X 2751; 37458 -CSK CSK P41240 human Src 6714 P12931 SRC human Y530 448235 FTstEPQyQPGENL_ X X 2105 -CSK CSK P41240 human Src 396442 P00523 SRC chicken Y527 448235 FTSTEPQyQPGENL_ X X 2105 -CSK CSK P41240 human P2X3 81739 P49654 P2rx3 rat Y393 9486200 QStDSGAySIGH___ X X -CSK CSK P41240 human Hck 3055 P08631 HCK human Y411 448168 RVIEDNEytAREGAk PK_Tyr_Ser-Thr X 2101; 6943; 59548; 70926; 78740; 94361; 17320 -CSK CSK P41240 human Src iso1 20779 P05480-1 Src mouse Y535 448235 FTSTEPQyQPGENL_ X 2105 -CSK CSK P41240 human Tau iso8 4137 P10636-8 MAPT human Y29 4103318 DRKDQGGytMHQDQE X -CSK CSK P41240 human Tau iso8 4137 P10636-8 MAPT human Y197 464351 KsGDRsGyssPGsPG X -CSK CSK P41240 human EEF2 1938 P13639 EEF2 human Y373 459352 kYRCELLyEGPPDDE X -CSK CSK P41240 human Src 6714 P12931 SRC human Y419 448234 RLIEDNEytARQGAk PK_Tyr_Ser-Thr X 2101; 6943; 59548; 70926; 78740; 94361; 17320 -CSK CSK P41240 human Fyn 2534 P06241 FYN human Y531 447883 FtAtEPQyQPGENL_ X -Prkd1 PRKD1 Q9WTQ1 rat CDH2 83501 Q9Z1Y3 Cdh2 rat S871 382737700 GSTAGsLssLNSSSS CADH_Y-type_LIR X X -Prkd1 PRKD1 Q9WTQ1 rat TRPV1 83810 O35433 Trpv1 rat S116 454886 PRLYDRRsIFDAVAQ X -Prkd1 PRKD1 Q9WTQ1 rat CDH2 83501 Q9Z1Y3 Cdh2 rat S872 382737702 STAGsLssLNSSSSG CADH_Y-type_LIR X X -Prkd1 PRKD1 Q9WTQ1 rat DRP1 114114 O35303 Dnm1l rat S656 483971 VPVARKLsAREQRDC X 4867; 6319 -Prkd1 PRKD1 Q9WTQ1 rat CDH2 83501 Q9Z1Y3 Cdh2 rat S869 382737701 GSGSTAGsLssLNSS CADH_Y-type_LIR X X -Prkd1 PRKD1 Q9WTQ1 rat PRKD1 85421 Q9WTQ1 Prkd1 rat S916 447632 KALSERVsIL_____ X X -MAPK7 ERK5 Q13164 human neurogenin 1 29410 P70595 Neurog1 rat S179 7590801 PCLPGPPsPASDTES X X -MAPK7 ERK5 Q13164 human ERK5 5598 Q13164 MAPK7 human S774 14561006 QADsAsLsAsLLADW X -MAPK7 ERK5 Q13164 human Fos 2353 P01100 FOS human T232 448491 GGLPEVAtPESEEAF X -MAPK7 ERK5 Q13164 human MEF2A 4205 Q02078 MEF2A human T319 448098 tPVVSVTtPSLPPQG X X -MAPK7 ERK5 Q13164 human MEK5 5607 Q13163 MAP2K5 human S149 455512 sNSLkKssAELKkIL X -MAPK7 ERK5 Q13164 human ERK5 5598 Q13164 MAPK7 human S772 21560204 DGQADsAsLsAsLLA X -MAPK7 ERK5 Q13164 human MEK5 5607 Q13163 MAP2K5 human S129 455509 VNTrAGPsQHSsPAV X -MAPK7 ERK5 Q13164 human neurogenin 1 29410 P70595 Neurog1 rat S208 7590802 SPLSDPSsPSASEDF X X -MAPK7 ERK5 Q13164 human MEF2A 4205 Q02078 MEF2A human S355 449934 SALQGFNsPGMLSLG X X -MAPK7 ERK5 Q13164 human SGK1 6446 O00141 SGK1 human S78 448430 ANPsPPPsPsQQINL X X 5599 -MAPK7 ERK5 Q13164 human MEK5 5607 Q13163 MAP2K5 human S137 455510 QHSsPAVsDSLPsNS X -MAPK7 ERK5 Q13164 human Ets-1 2113 P14921 ETS1 human T38 447950 CADVPLLtPSSkEMM X X -MAPK7 ERK5 Q13164 human ERK5 5598 Q13164 MAPK7 human S770 14561007 PQDGQADsAsLsAsL X -MAPK7 ERK5 Q13164 human ERK5 5598 Q13164 MAPK7 human T733 455520 LPPVFsGtPKGSGAG X X -MAPK7 ERK5 Q13164 human PML 5371 P29590 PML human S403 3189643 AAVskkAsPEAAstP DUF3583 X -MAPK7 ERK5 Q13164 human ERK5 5598 Q13164 MAPK7 human S731 455519 DPLPPVFsGtPKGSG X X -MAPK7 ERK5 Q13164 human ERK5 5598 Q13164 MAPK7 human S496 455518 SRLRDGPsAPLEAPE X -MAPK7 ERK5 Q13164 human Fos 2353 P01100 FOS human S32 470080 DSLSYyHsPADSFSS X 5348; 8709; 8677; 99325 -MAPK7 ERK5 Q13164 human GJA1 24392 P08050 Gja1 rat S255 448852 HATTGPLsPskDCGs X X -MAPK7 ERK5 Q13164 human MEF2D 17261 Q63943 Mef2d mouse S180 449933 LTDPRLLsPQQPALQ X X -MAPK7 ERK5 Q13164 human ERK5 5598 Q13164 MAPK7 human S421 455516 CPDVEMPsPWAPSGD X -MAPK7 ERK5 Q13164 human MEF2A 4205 Q02078 MEF2A human T312 448097 QATQPLAtPVVSVTt X X -MAPK7 ERK5 Q13164 human ERK5 5598 Q13164 MAPK7 human T28 455514 VkAEPAHtAAsVAAk X -MAPK7 ERK5 Q13164 human DLG1 1739 Q12959 DLG1 human S158 2024309 FVsHsHIsPIKPTEA MAGUK_N_PEST X -MAPK7 ERK5 Q13164 human MEK5 5607 Q13163 MAP2K5 human S142 455511 AVsDSLPsNSLkKss X -MAPK7 ERK5 Q13164 human MEF2C iso3 4208 Q06413-3 MEF2C human S387 1729600 TRHEAGRsPVDSLSS X X -MAPK7 ERK5 Q13164 human NFAT3 73181 Q8K120 Nfatc4 mouse S170 448860 GGAFFsPsPGSSSLS X -MAPK7 ERK5 Q13164 human Myc 4609 P01106 MYC human S77 448586 LLPtPPLsPsRRsGL Myc_N X X 13748 -MAPK7 ERK5 Q13164 human SMURF2 66313 A2A5Z6 Smurf2 mouse T249 27457334 MSRTHLHtPPDLPEG X -MAPK7 ERK5 Q13164 human PML 5371 P29590 PML human T409 469197 AsPEAAstPRDPIDV DUF3583 X -MAPK7 ERK5 Q13164 human ERK5 5598 Q13164 MAPK7 human S433 455517 SGDCAMEsPPPAPPP X -MAPK7 ERK5 Q13164 human NFAT3 73181 Q8K120 Nfatc4 mouse S168 448859 QGGGAFFsPsPGSSS X -HIPK2 HIPK2 Q9H2X6 human HIPK2 28996 Q9H2X6 HIPK2 human T838 7447086 SKRVKENtPPRCAMV X -HIPK2 HIPK2 Q9H2X6 human PAX6 18508 P63015 Pax6 mouse T373 458810 GRSYDTYtPPHMQTH X X -HIPK2 HIPK2 Q9H2X6 human ZBTB4 57659 Q9P1Z0 ZBTB4 human T797 9184306 ERPGGtPtPVIAYsK X -HIPK2 HIPK2 Q9H2X6 human p53 22059 P02340 Tp53 mouse S58 2624500 EEFFEGPsEALRVSG X -HIPK2 HIPK2 Q9H2X6 human KLF3 51274 P57682 KLF3 human S78 4728755 sPPsAGNsPSSLKFP X -HIPK2 HIPK2 Q9H2X6 human PAX6 18508 P63015 Pax6 mouse T304 458809 QPIPQPTtPVsSFTS X X -HIPK2 HIPK2 Q9H2X6 human SIAH2 6478 O43255 SIAH2 human S68 5393502 GGGAGPVsPQHHELT X -HIPK2 HIPK2 Q9H2X6 human HMGA1 3159 P17096 HMGA1 human T78 451516 ktrkttttPGrkPrG X -HIPK2 HIPK2 Q9H2X6 human HIPK2 28996 Q9H2X6 HIPK2 human S827 7447082 SSSQAIssPQRSKRV X -HIPK2 HIPK2 Q9H2X6 human PAX6 18508 P63015 Pax6 mouse T281 458808 QRRQASNtPSHIPIS X X -HIPK2 HIPK2 Q9H2X6 human CTBP1 1487 Q13363 CTBP1 human S422 455350 AHPPHAPsPGQTVkP X X -HIPK2 HIPK2 Q9H2X6 human PML 5371 P29590 PML human S36 451469 PSEGRQPsPsPsPtE X -HIPK2 HIPK2 Q9H2X6 human TLE1 7088 Q04724 TLE1 human S289 24987529 DAsssPAstAsSASS X -HIPK2 HIPK2 Q9H2X6 human SIAH2 6478 O43255 SIAH2 human T119 26371004 PTCRGALtPSIRNLA X -HIPK2 HIPK2 Q9H2X6 human MECP2 4204 P51608 MECP2 human S216 18012096 VkRVLEKsPGkLLVk X X -HIPK2 HIPK2 Q9H2X6 human MECP2 4204 P51608 MECP2 human S80 452713 AVPEAsAsPKQRRsI X -HIPK2 HIPK2 Q9H2X6 human p53 7157 P04637 TP53 human S46 447536 AMDDLMLsPDDIEQW TAD2 X X 2521 -HIPK2 HIPK2 Q9H2X6 human SIRT1 23411 Q96EB6 SIRT1 human S682 41401500 SDSGTCQsPSLEEPM X X -HIPK2 HIPK2 Q9H2X6 human AML1 861 Q01196 RUNX1 human S276 454401 VHPAtPIsPGRASGM X -HIPK2 HIPK2 Q9H2X6 human PML 5371 P29590 PML human S8 470923 MEPAPARsPRPQQDP X -HIPK2 HIPK2 Q9H2X6 human p300 2033 Q09472 EP300 human S2279 486262 PVQPNPMsPQQHMLP X -HIPK2 HIPK2 Q9H2X6 human HIPK2 28996 Q9H2X6 HIPK2 human T880 29668000 QTIVIPDtPsPTVSV X X -HIPK2 HIPK2 Q9H2X6 human CBX4 8535 O00257 CBX4 human T497 470079 SLQVkPEtPASAAVA X -HIPK2 HIPK2 Q9H2X6 human HIPK2 28996 Q9H2X6 HIPK2 human Y361 449571 SkAVCstyLQsRYyR Pkinase X -HIPK2 HIPK2 Q9H2X6 human KLF3 51274 P57682 KLF3 human S108 4728775 sPPIKKysPPsPGVQ X -HIPK2 HIPK2 Q9H2X6 human KLF3 51274 P57682 KLF3 human S101 3193282 GLsMPsssPPIKKys X -HIPK2 HIPK2 Q9H2X6 human TLE1 7088 Q04724 TLE1 human S286 5707650 LKkDAsssPAstAsS X -HIPK2 HIPK2 Q9H2X6 human PDX1 18609 P52946 Pdx1 mouse S211 15103411 KEEDKKRsSGtPSGG X -HIPK2 HIPK2 Q9H2X6 human C/EBP-beta 1051 P17676 CEBPB human S76 456166 HERAIDFsPyLEPLG X X -HIPK2 HIPK2 Q9H2X6 human ZBTB4 57659 Q9P1Z0 ZBTB4 human T983 9184305 AAPPAPPtPPPPTLP X -HIPK2 HIPK2 Q9H2X6 human HMGA1 3159 P17096 HMGA1 human S36 455950 PRkQPPVsPGtALVG X -HIPK2 HIPK2 Q9H2X6 human SIRT1 23411 Q96EB6 SIRT1 human S27 452898 ADREAAssPAGEPLR X 2327 -HIPK2 HIPK2 Q9H2X6 human HIPK2 28996 Q9H2X6 HIPK2 human S364 4783726 VCstyLQsRYyRAPE Pkinase X -HIPK2 HIPK2 Q9H2X6 human HDAC3 8841 O15379 HDAC3 human S374 1874020216 KMLNHAPsVQIHDVP X -HIPK2 HIPK2 Q9H2X6 human p63 8626 Q9H3D4 TP63 human T491 4668106 PQQRNALtPTTIPDG X X -HIPK2 HIPK2 Q9H2X6 human HIPK2 15258 Q9QZR5 Hipk2 mouse Y361 449571 SKAVCStyLQsRYYR Pkinase X -HIPK2 HIPK2 Q9H2X6 human HIPK2 28996 Q9H2X6 HIPK2 human S924 25740749 SCVTVHDsPYSDSSS X -HIPK2 HIPK2 Q9H2X6 human AML1 861 Q01196 RUNX1 human S249 454399 DTRQIQPsPPWsyDQ X 4327 -HIPK2 HIPK2 Q9H2X6 human TLE1 7088 Q04724 TLE1 human S239 454385 KDSsHYDsDGDKsDD X -HIPK2 HIPK2 Q9H2X6 human KLF3 51274 P57682 KLF3 human S250 4728795 KRPLPVEsPDtQRKR X X -HIPK2 HIPK2 Q9H2X6 human Notch 1 4851 P46531 NOTCH1 human T2511 483083 VPEHPFLtPsPEsPD X -HIPK2 HIPK2 Q9H2X6 human SIAH2 6478 O43255 SIAH2 human T26 5393503 PPPQPQHtPsPAAPP X -HIPK2 HIPK2 Q9H2X6 human CTBP2 1488 P56545 CTBP2 human S428 3198539 AHPSQAPsPNQPTKH X X -HIPK2 HIPK2 Q9H2X6 human HMGA1 iso2 3159 P17096-2 HMGA1 human T67 451516 kTRkTTTtPGRkPrG X -HIPK2 HIPK2 Q9H2X6 human HIPK2 28996 Q9H2X6 HIPK2 human S848 29668002 RCAMVHSsPACSTSV X -HIPK2 HIPK2 Q9H2X6 human PPM1D 8493 O15297 PPM1D human S85 28847901 PLPDAGAsPAPsRCC PP2C X X -HIPK2 HIPK2 Q9H2X6 human AML1 861 Q01196 RUNX1 human T273 454403 sPsVHPAtPIsPGRA X -HIPK2 HIPK2 Q9H2X6 human HIPK2 28996 Q9H2X6 HIPK2 human S934 25740745 SDSSSNTsPYSVQQR X -HIPK2 HIPK2 Q9H2X6 human PDX1 18609 P52946 Pdx1 mouse S269 11279404 LPsGLSVsPQPSSIA X X -HIPK2 HIPK2 Q9H2X6 human KLF3 51274 P57682 KLF3 human S224 4728790 PPLMNsVsPPQALLQ X -HIPK2 HIPK2 Q9H2X6 human KLF3 51274 P57682 KLF3 human S111 4728780 IKKysPPsPGVQPFG X -HIPK2 HIPK2 Q9H2X6 human HMGA1 3159 P17096 HMGA1 human T53 451515 kEPsEVPtPkRPrGr X -HIPK2 HIPK2 Q9H2X6 human KLF3 51274 P57682 KLF3 human S71 4728750 LTVNKRSsPPsAGNs X -HIPK2 HIPK2 Q9H2X6 human PPM1D 8493 O15297 PPM1D human S54 28847900 QPLPPRPsPAALPGG X -HIPK2 HIPK2 Q9H2X6 human HIPK2 28996 Q9H2X6 HIPK2 human S668 27732212 GFQGLQAsPSkHAGY X -HIPK2 HIPK2 Q9H2X6 human p27Kip1 1027 P46527 CDKN1B human S10 447874 NVRVSNGsPsLErMD X X -HIPK2 HIPK2 Q9H2X6 human HIPK2 28996 Q9H2X6 HIPK2 human S882 29668001 IVIPDtPsPTVSVIT X X -HIPK2 HIPK2 Q9H2X6 human ZBTB4 57659 Q9P1Z0 ZBTB4 human T795 9184304 AAERPGGtPtPVIAY X -HIPK2 HIPK2 Q9H2X6 human ELF4 2000 Q99607 ELF4 human S369 1867984201 ASLELGPsLDEEIPT X -HIPK2 HIPK2 Q9H2X6 human CREB 1385 P16220 CREB1 human S257 14159739 PGVVMAssPALPTQP X X -HIPK2 HIPK2 Q9H2X6 human KLF3 51274 P57682 KLF3 human S92 3193285 PSSHRRAsPGLsMPs X -HIPK2 HIPK2 Q9H2X6 human PML 5371 P29590 PML human S38 451470 EGRQPsPsPsPtERA X X -HIPK2 HIPK2 Q9H2X6 human HMGA1 iso2 3159 P17096-2 HMGA1 human T42 451515 kEPsEVPtPkrPrGr X -HIPK2 HIPK2 Q9H2X6 human PDX1 18609 P52946 Pdx1 mouse T214 15103412 DKKRsSGtPSGGGGG X -HIPK2 HIPK2 Q9H2X6 human SIAH2 6478 O43255 SIAH2 human S28 471339 PQPQHtPsPAAPPAA X X -HIPK2 HIPK2 Q9H2X6 human C/EBP-beta 1051 P17676 CEBPB human T235 447878 SsssPPGtPSPADAK X X 3084 -HIPK2 HIPK2 Q9H2X6 human KLF3 51274 P57682 KLF3 human S216 4728785 DYYPEEMsPPLMNsV X -HIPK2 HIPK2 Q9H2X6 human spastin 6683 Q9UBP0 SPAST human S268 1211782 sGHHRAPsySGLSMV X X -Sik2 QIK Q3LRT3 rat QIK 315649 Q3LRT3 Sik2 rat S179 2560901 LLAtWCGsPPYAAPE Pkinase X -Pim1 Pim1 P26794 rat SKP2 6502 Q13309 SKP2 human T417 15165300 WGIkCRLtLQkPSCL X -Pim1 Pim1 P26794 rat SKP2 6502 Q13309 SKP2 human S64 457412 sNLGHPEsPPRkRLk X 14865 -Pim1 Pim1 P26794 rat SKP2 6502 Q13309 SKP2 human S72 480507 PPRkRLkskGsDkDF X -TAOK2 TAO2 Q9UL54 human RhoE 390 P61587 RND3 human S210 27933600 KNVKRNKsQRATKRI X X -TAOK2 TAO2 Q9UL54 human RhoE 390 P61587 RND3 human S218 25307985 QRATKRIsHMPsRPE X -TAOK2 TAO2 Q9UL54 human SEPT7 235072 O55131 Septin7 mouse T425 476328 EQQnssRtLEKNKKK X -TAOK2 TAO2 Q9UL54 human TAO2 9344 Q9UL54 TAOK2 human S181 7447419 SIMAPANsFVGtPYW Pkinase X -TAOK2 TAO2 Q9UL54 human RhoE 390 P61587 RND3 human S240 27933601 LRKDKAKsCTVM___ X -TAOK2 TAO2 Q9UL54 human SEPT7 989 Q16181 SEPTIN7 human T426 476328 EQQNssrtLEKNKKK X -Fgfr1 FGFR1 Q63827 rat FGFR1 79114 Q63827 Fgfr1 rat Y683 478646 LSMPLDQySPSFPDT X -Fgfr1 FGFR1 Q63827 rat FGFR1 79114 Q63827 Fgfr1 rat Y560 447918 RDIHHIDyyKKTTNG PK_Tyr_Ser-Thr X 3471; 3476; 52928 -Fgfr1 FGFR1 Q63827 rat FGFR1 79114 Q63827 Fgfr1 rat Y584 447920 EALFDRIyTHQSDVW PK_Tyr_Ser-Thr X -Fgfr1 FGFR1 Q63827 rat FGFR1 79114 Q63827 Fgfr1 rat Y673 447922 ALTSNQEyLDLSMPL X 84309 -Fgfr1 FGFR1 Q63827 rat FGFR1 79114 Q63827 Fgfr1 rat Y561 447919 DIHHIDyyKKTTNGR PK_Tyr_Ser-Thr X 3471; 3476; 52928 -Fgfr1 FGFR1 Q63827 rat FGFR1 79114 Q63827 Fgfr1 rat Y637 448642 SNCTNELyMMMRDCW PK_Tyr_Ser-Thr X -Fgfr1 FGFR1 Q63827 rat FGFR1 79114 Q63827 Fgfr1 rat Y608 447921 FTLGGSPyPGVPVEE PK_Tyr_Ser-Thr X -Fgr FGR P14234 mouse SDHA 66945 Q8K2B3 Sdha mouse Y604 1458603 YkVRVDEyDYSkPIQ Succ_DH_flav_C X X -Mapk12 P38G O08911 mouse MyoD 4654 P15172 MYOD1 human S201 40684505 SGDSDAssPRsNCsD Myf5 X -Mapk12 P38G O08911 mouse GYS1 2997 P13807 GYS1 human T84 1875332200 VELLEAPtPALkRTL Glycogen_syn X -Mapk12 P38G O08911 mouse GYS1 2997 P13807 GYS1 human S723 4787599 sssLStPsEPLsPts X -Mapk12 P38G O08911 mouse MyoD 4654 P15172 MYOD1 human S200 452000 YSGDSDAssPRsNCs Myf5 X -Mapk12 P38G O08911 mouse PFKFB3 170768 Q9ESY2 Pfkfb3 mouse S467 468406 NsVtPLAsPEPTKKP X X -Mapk12 P38G O08911 mouse GYS1 2997 P13807 GYS1 human S727 457615 StPsEPLsPtssLGE X -Mapk12 P38G O08911 mouse GYS1 2997 P13807 GYS1 human T721 457616 AtsssLStPsEPLsP X -Mapk12 P38G O08911 mouse GYS1 2997 P13807 GYS1 human T278 1875332700 kRkPDIVtPNGLNVk Glycogen_syn X -Epha8 EphA8 O09127 mouse EphA8 13842 O09127 Epha8 mouse Y838 448559 LAYGERPyWNMTNQD PK_Tyr_Ser-Thr X -Epha8 EphA8 O09127 mouse EphA8 13842 O09127 Epha8 mouse Y615 448558 FSAEPHTyEEPGRAG EphA2_TM X -Ntrk2 TrkB P15209 mouse TIAM1 21844 Q60610 Tiam1 mouse Y829 465610 PQPEEDIyELLYKEI RBD X -Ntrk2 TrkB P15209 mouse TrkB 18212 P15209 Ntrk2 mouse Y515 448813 PVIENPQyFGITNSQ X 4619 -MTOR mTOR P42345 human ULK1 22241 O70405 Ulk1 mouse S757 483139 PVVFtVGsPPsGAtP X 14202; 6888; 29313 -MTOR mTOR P42345 human ANKRD17 26057 O75179 ANKRD17 human S2047 484760 VssPssPsPPAQPGG X -MTOR mTOR P42345 human IRS1 3667 P35568 IRS1 human S636 447506 sGDyMPMsPKsVSAP X 2388 -MTOR mTOR P42345 human RRAGC 64121 Q9HB90 RRAGC human S21 14579528 GsYGAADsFPKDFGY X X -MTOR mTOR P42345 human Mnk2 2872 Q9HBH9 MKNK2 human S74 456328 KRGRAtDsFsGRFED X X -MTOR mTOR P42345 human TFE3 209446 Q64092 Tfe3 mouse S320 53350801 PAITVSNsCPAELPN X -MTOR mTOR P42345 human ULK1 8408 O75385 ULK1 human S758 483139 PVVFtVGsPPsGStP X 14202; 6888; 29313 -MTOR mTOR P42345 human BRD9 65980 Q9H8M2 BRD9 human S588 7231552 DPYEFLQsPEPAAsA X -MTOR mTOR P42345 human IGF2BP1 140486 O88477 Igf2bp1 mouse S181 453893 RGQPRQGsPVAAGAP X -MTOR mTOR P42345 human WASHC2A 387680 Q641Q2 WASHC2A human S700 20621635 DDVDSGGsLFGsPPT X -MTOR mTOR P42345 human ER-alpha 2099 P03372 ESR1 human S104 448099 FPPLNsVsPsPLMLL Oest_recep X X -MTOR mTOR P42345 human UVRAG 7405 Q9P2Y5 UVRAG human S549 7447343 RKItsLSssLDTsLD X -MTOR mTOR P42345 human TFEB 7942 P19484 TFEB human S122 3181616 PkPPPAAsPGVRAGH MITF_TFEB_C_3_N X 86843; 87932 -MTOR mTOR P42345 human SRm160 10250 Q8IYB3 SRRM1 human T574 453188 PRRRRtPtPPPRRRt X -MTOR mTOR P42345 human LPIN1 14245 Q91ZP3 Lpin1 mouse S472 471355 GARsANQsPQsVGGs X -MTOR mTOR P42345 human SENP3 26168 Q9H4L4 SENP3 human S143 36438203 LLYsKstsLtFHWKL X X -MTOR mTOR P42345 human SENP3 26168 Q9H4L4 SENP3 human T145 36438202 YsKstsLtFHWKLWG X X -MTOR mTOR P42345 human mTOR 2475 P42345 MTOR human S2448 447578 RsRtRtDsysAGQsV X 2971; 2976; 5536; 54932 -MTOR mTOR P42345 human mTOR 56717 Q9JLN9 Mtor mouse S2481 447498 tVPEsIHsFIGDGLV X 2974 -MTOR mTOR P42345 human DAP 1611 P51397 DAP human S51 471098 DQEWEsPsPPkPtVF DAP X -MTOR mTOR P42345 human SENP3 26168 Q9H4L4 SENP3 human S25 4172600 PGIPPAyssPRRERL X X -MTOR mTOR P42345 human PKN2 5586 Q16513 PKN2 human T958 2509079 TsEAPILtPPREPRI Pkinase_C X X -MTOR mTOR P42345 human p70S6K 6198 P23443 RPS6KB1 human T412 448607 NQVFLGFtyVAPsVL Pkinase_C X X 9206; 9234; 9205; 9209; 97596 -MTOR mTOR P42345 human MCL1 4170 Q07820 MCL1 human S64 479431 IGGSAGAsPPStLtP X X 13297 -MTOR mTOR P42345 human Akt1 207 P31749 AKT1 human S473 447855 RPHFPQFsysAsGtA Pkinase_C X X 9271; 3787; 4060; 4051; 5102; 4058; 2336; 2337; 4075; 4070; 5012; 4071; 92982; 5315; 9563; 9018; 12694; 52240; 11962; 15116; 88106; 26580; 68035; 31957; 23430; 20235 -MTOR mTOR P42345 human NRBF2 29982 Q96F24 NRBF2 human S120 476484 sPLsQkYsPSTEKCL NRBF2 X X -MTOR mTOR P42345 human SRm160 10250 Q8IYB3 SRRM1 human T572 453187 PPPRRRRtPtPPPRR X -MTOR mTOR P42345 human IKBKAP 8518 O95163 ELP1 human S1174 3178326 SETSsVVsGSEMSGK X -MTOR mTOR P42345 human p70S6K 83840 P67999 Rps6kb1 rat T412 448607 NQVFLGFtYVAPSVL Pkinase_C X 9206; 9234; 9205; 97596 -MTOR mTOR P42345 human NAA10 8260 P41227 NAA10 human S228 3190219 StDVKDssEAsDSAS X X -MTOR mTOR P42345 human TFEB 7942 P19484 TFEB human S211 25529700 LVGVTSSsCPADLTQ X 37681 -MTOR mTOR P42345 human PARK2 5071 O60260 PRKN human S127 1876336800 AVILHTDsRkDsPPA X X -MTOR mTOR P42345 human AR 367 P10275 AR human S96 448416 QQQGEDGsPQAHRRG Androgen_recep X X -MTOR mTOR P42345 human IRS1 25467 P35570 Irs1 rat S635 447507 yMPMsPKsVsAPQQI X 2388 -MTOR mTOR P42345 human mTOR 2475 P42345 MTOR human S2478 458290 tGttVPEsIHsFIGD X -MTOR mTOR P42345 human PASK 23178 Q96RG2 PASK human T640 1872667500 MAGLSFGtPtLDEPW X -MTOR mTOR P42345 human PRAS40 84335 Q96B36 AKT1S1 human S183 482839 PTQQYAKsLPVSVPV PRAS X X 5936 -MTOR mTOR P42345 human IRS1 16367 P35569 Irs1 mouse S302 450190 TRRSRtEsITAtsPA X 2384; 2491 -MTOR mTOR P42345 human LARP6 55323 Q9BRS8 LARP6 human S409 10942100 GRLNCStsPEIFRKC X -MTOR mTOR P42345 human SRm300 23524 Q9UQ35 SRRM2 human S1318 470844 sPEHKELsNsPLREN X -MTOR mTOR P42345 human IRS1 16367 P35569 Irs1 mouse S635 447507 yMPMsPKsVsAPQQI X 2388 -MTOR mTOR P42345 human SLC4A4 54403 O88343 Slc4a4 mouse S245 2047937 FSNPDNGsPAMtHRN Band_3_cyto X -MTOR mTOR P42345 human UNK 85451 Q9C0B0 UNK human S611 1880742152 GtsAsHGsLGLNGMN X X -MTOR mTOR P42345 human UVRAG 7405 Q9P2Y5 UVRAG human S498 1222327 GFsGGIPsPDKGHRK X X -MTOR mTOR P42345 human DNMT1 1786 P26358 DNMT1 human S714 452655 DNIPEMPsPkKMHQG X -MTOR mTOR P42345 human ULK1 8408 O75385 ULK1 human S638 3176158 FDFPKtPssQNLLAL X 14205 -MTOR mTOR P42345 human Sin1 79109 Q9BPZ7 MAPKAP1 human S260 28758701 PIHKFGFsTLALVEK CRIM X -MTOR mTOR P42345 human p70S6K 72508 Q8BSK8 Rps6kb1 mouse T412 448607 NQVFLGFtYVAPSVL Pkinase_C X X 9206; 9234; 9205; 97596 -MTOR mTOR P42345 human UNK 85451 Q9C0B0 UNK human S606 1880742148 ENTFLGtsAsHGsLG X -MTOR mTOR P42345 human LPIN1 14245 Q91ZP3 Lpin1 mouse S106 471342 IPMYLATsPILsEGA Lipin_N X -MTOR mTOR P42345 human HOXB13 10481 Q92826 HOXB13 human S31 1883583910 GRNLVAHsPLTSHPA X -MTOR mTOR P42345 human Akt1 207 P31749 AKT1 human T450 447857 tAQMItItPPDQDDs Pkinase_C X 9267; 12178 -MTOR mTOR P42345 human RRM1 6240 P23921 RRM1 human S631 41454201 IYTRRVLsGEFQIVN Ribonuc_red_lgC X X -MTOR mTOR P42345 human GRB10 2887 Q13322 GRB10 human S476 455870 MNILGsQsPLHPSTL X 11817 -MTOR mTOR P42345 human DUSP10 11221 Q9Y6W6 DUSP10 human S224 38520204 SCREGKDsFKRIFsK Rhodanese X -MTOR mTOR P42345 human WASHC2A 387680 Q641Q2 WASHC2A human S704 20621638 SGGsLFGsPPTSVPP X -MTOR mTOR P42345 human PKCE 5581 Q02156 PRKCE human T710 450184 TREEPVLtLVDEAIV Pkinase_C X -MTOR mTOR P42345 human STK11IP 114790 Q8N1F8 STK11IP human S404 4716927 EPRTLNPsPAGWFVQ X X -MTOR mTOR P42345 human LARP 23367 Q6PKG0 LARP1 human S774 453830 LPttVPEsPNyRNtR X -MTOR mTOR P42345 human FBXW8 231672 Q8BIA4 Fbxw8 mouse S86 4751099 DTSSRsRsPPDRDAt X X -MTOR mTOR P42345 human UNK 85451 Q9C0B0 UNK human S336 1880742106 QPSsAVssPtQPGPV X -MTOR mTOR P42345 human UNK 85451 Q9C0B0 UNK human S608 1880742150 TFLGtsAsHGsLGLN X -MTOR mTOR P42345 human MAF1 84232 Q9H063 MAF1 human S60 3211917 PHVLEALsPPQtsGL Maf1 X X -MTOR mTOR P42345 human AMOTL2 51421 Q9Y2J4 AMOTL2 human S759 477928 SsSQRAAsLDsVATS X X -MTOR mTOR P42345 human 4E-BP1 1978 Q13541 EIF4EBP1 human S44 3195716 tPGGtLFsttPGGtR eIF_4EBP X -MTOR mTOR P42345 human PASK 23178 Q96RG2 PASK human S953 1872667503 FLAsLPGstHsTAAE X -MTOR mTOR P42345 human UVRAG 7405 Q9P2Y5 UVRAG human S582 37039801 GHANVHPsQEQGEAL X -MTOR mTOR P42345 human SENP3 26168 Q9H4L4 SENP3 human S141 36438201 RMLLYsKstsLtFHW X X -MTOR mTOR P42345 human mTOR 2475 P42345 MTOR human T2473 458288 PAHKKtGttVPEsIH X -MTOR mTOR P42345 human N-Myc 4613 P04198 MYCN human S62 448222 LLPtPPLsPsrGFAE Myc_N X -MTOR mTOR P42345 human IRS1 16367 P35569 Irs1 mouse S632 447506 NGDyMPMsPKsVsAP X 2388 -MTOR mTOR P42345 human GRB10 14783 Q60760 Grb10 mouse S501 4727990 TRMNILSsQsPLHPS X -MTOR mTOR P42345 human Raptor 57521 Q8N122 RPTOR human S859 2024885 DtssLtQsAPAsPtN X X -MTOR mTOR P42345 human 4E-BP1 1978 Q13541 EIF4EBP1 human S65 447527 FLMECrNsPVtktPP eIF_4EBP X X 9451; 9456; 13443 -MTOR mTOR P42345 human NDRG1 10397 Q92597 NDRG1 human T346 454245 GtRsRsHtsEGtRsR X 3217; 5482; 6992; 7497; 8947; 89166 -MTOR mTOR P42345 human SOD1 6647 P00441 SOD1 human T40 1100571300 WGsIkGLtEGLHGFH Sod_Cu X -MTOR mTOR P42345 human IRS1 25467 P35570 Irs1 rat S632 447506 NGDyMPMsPKsVsAP X 2388 -MTOR mTOR P42345 human PKCB 5579 P05771 PRKCB human T642 447897 TRQPVELtPtDKLFI Pkinase_C X -MTOR mTOR P42345 human EEF2K 29904 O00418 EEF2K human S72 3150896 ksERysssGsPANsF X -MTOR mTOR P42345 human SRm300 23524 Q9UQ35 SRRM2 human S1329 459983 LRENsFGsPLEFRNs X -MTOR mTOR P42345 human mTOR 2475 P42345 MTOR human S2454 4780698 DsysAGQsVEILDGV X -MTOR mTOR P42345 human mTOR 2475 P42345 MTOR human S2481 447498 tVPEsIHsFIGDGLV X X 2974 -MTOR mTOR P42345 human ELL 8178 P55199 ELL human S309 3192127 LGDPAAssPPGERGR X -MTOR mTOR P42345 human 4E-BP1 13685 Q60876 Eif4ebp1 mouse T36 447497 PPGDysttPGGtLFs eIF_4EBP X 2855; 9459; 2846; 4923; 5123; 3929; 7547; 45613; 39788 -MTOR mTOR P42345 human EEF2K 29904 O00418 EEF2K human S74 3150899 ERysssGsPANsFHF X -MTOR mTOR P42345 human ER-alpha 2099 P03372 ESR1 human S118 448101 LHPPPQLsPFLQPHG Oest_recep X 2511 -MTOR mTOR P42345 human TORC2 74343 Q3U182 Crtc2 mouse S136 454632 PySPAYLsPPPEsGW X X -MTOR mTOR P42345 human DEPTOR 64798 Q8TB45 DEPTOR human T295 4723863 GyFsssPtLsssPPV X -MTOR mTOR P42345 human p70S6K 6198 P23443 RPS6KB1 human S394 448806 TRQtPVDsPDDStLS Pkinase_C X X 9208 -MTOR mTOR P42345 human PASK 23178 Q96RG2 PASK human S956 1872667502 sLPGstHsTAAELTG X -MTOR mTOR P42345 human ER-alpha 2099 P03372 ESR1 human S106 448100 PLNsVsPsPLMLLHP Oest_recep X X -MTOR mTOR P42345 human ATG13 51897 Q91YI1 Atg13 mouse S258 53377100 CTTSFSTsPPSQLSS X X -MTOR mTOR P42345 human SENP3 26168 Q9H4L4 SENP3 human S26 4957737 GIPPAyssPRRERLR X X -MTOR mTOR P42345 human SQSTM1 18412 Q64337 Sqstm1 mouse S351 14580829 SsKEVDPsTGELQsL X X 95697; 16177; 12074 -MTOR mTOR P42345 human DEPTOR 64798 Q8TB45 DEPTOR human S293 3897131 ssGyFsssPtLsssP X X -MTOR mTOR P42345 human SENP3 26168 Q9H4L4 SENP3 human S139 36438204 AFRMLLYsKstsLtF X X -MTOR mTOR P42345 human HOXB13 10481 Q92826 HOXB13 human T41 1883583908 TSHPAAPtLMPAVNY X -MTOR mTOR P42345 human BAG3 9531 O95817 BAG3 human T285 467534 GsPARsstPLHsPsP X -MTOR mTOR P42345 human RPRD1B 58490 Q9NQG5 RPRD1B human S166 452984 DDyPGsysPQDPsAG X -MTOR mTOR P42345 human SLC7A11 23657 Q9UPY5 SLC7A11 human S26 470841 NVNGRLPsLGNkEPP X X -MTOR mTOR P42345 human PASK 23178 Q96RG2 PASK human T642 1872667501 GLSFGtPtLDEPWLG X -MTOR mTOR P42345 human 4E-BP1 1978 Q13541 EIF4EBP1 human T70 447528 rNsPVtktPPRDLPt eIF_4EBP X X 9455; 13396 -MTOR mTOR P42345 human PKCE 5581 Q02156 PRKCE human S729 448789 QEEFKGFsYFGEDLM Pkinase_C X 9371 -MTOR mTOR P42345 human SRm300 23524 Q9UQ35 SRRM2 human S1326 453289 NsPLRENsFGsPLEF X -MTOR mTOR P42345 human UNK 85451 Q9C0B0 UNK human S255 41455256 RKHKYRSsPCPNVKH X -MTOR mTOR P42345 human PATL1 219988 Q86TB9 PATL1 human S179 453577 ALPRRstsPIIGsPP X -MTOR mTOR P42345 human SGK1 20393 Q9WVC6 Sgk1 mouse S422 448429 AEAFLGFsYAPPVDS Pkinase_C X -MTOR mTOR P42345 human RRAGC 64121 Q9HB90 RRAGC human T394 6732849 kALTHNGtPRNAI__ X -MTOR mTOR P42345 human GRB10 2887 Q13322 GRB10 human S428 455333 stPVRsVsENsLVAM BPS X -MTOR mTOR P42345 human UVRAG 7405 Q9P2Y5 UVRAG human S571 7447346 KGEDLVGsLNGGHAN X X -MTOR mTOR P42345 human SGK1 6446 O00141 SGK1 human S422 448429 AEAFLGFsYAPPTDS Pkinase_C X X -MTOR mTOR P42345 human APBA3 9546 O96018 APBA3 human S7 29668009 _MDFPtIsRsPsGPP X -MTOR mTOR P42345 human YAP1 10413 P46937 YAP1 human S436 1874499600 INQSTLPsQQNRFPD X X -MTOR mTOR P42345 human ZNRF2 223082 Q8NHG8 ZNRF2 human S145 4742836 GPRLVIGsLPAHLsP X X -MTOR mTOR P42345 human S6 6194 P62753 RPS6 human S236 448093 AKRRRLssLRAstsK X 5006; 4856; 4857; 4858; 4851; 4803; 2211; 3945; 3985; 5316; 4854; 8520; 48319; 40643; 9865; 38573; 14733; 27036; 34411; 62016; 62788; 81736; 97935; 99457; 15448 -MTOR mTOR P42345 human Raptor 57521 Q8N122 RPTOR human S863 453732 LtQsAPAsPtNkGVH X X -MTOR mTOR P42345 human NFAT3 73181 Q8K120 Nfatc4 mouse S170 448860 GGAFFsPsPGSSSLS X -MTOR mTOR P42345 human OSR1 9943 O95747 OXSR1 human S339 449248 EDGGWEWsDDEFDEE X -MTOR mTOR P42345 human ISCU 23479 Q9H1K1 ISCU human S14 469833 FRLRRAAsALLLRsP X X -MTOR mTOR P42345 human PATL1 219988 Q86TB9 PATL1 human S184 467884 stsPIIGsPPVRAVP X -MTOR mTOR P42345 human UVRAG 7405 Q9P2Y5 UVRAG human S550 4761506 KItsLSssLDTsLDF X X -MTOR mTOR P42345 human BAG3 9531 O95817 BAG3 human S289 469169 RsstPLHsPsPIRVH X -MTOR mTOR P42345 human DEPTOR 64798 Q8TB45 DEPTOR human S286 21697912 ssMssCGssGyFsss X -MTOR mTOR P42345 human LPIN1 14245 Q91ZP3 Lpin1 mouse S237 15502156 PSSDREWsPsPSSLV X -MTOR mTOR P42345 human IRS1 3667 P35568 IRS1 human S639 447507 yMPMsPKsVSAPQQI X 2388 -MTOR mTOR P42345 human 4E-BP1 1978 Q13541 EIF4EBP1 human T37 447497 PPGDysttPGGtLFs eIF_4EBP X X 2855; 9459; 2846; 5123; 3929; 7547; 45613; 39788 -MTOR mTOR P42345 human HSF1 3297 Q00613 HSF1 human S303 449045 RVkEEPPsPPQsPRV Vert_HS_TF X -MTOR mTOR P42345 human p70S6K 6198 P23443 RPS6KB1 human S434 448356 sFEPKIRsPRRFIGs X -MTOR mTOR P42345 human Myc 4609 P01106 MYC human S77 448586 LLPtPPLsPsRRsGL Myc_N X 13748 -MTOR mTOR P42345 human 4E-BP1 1978 Q13541 EIF4EBP1 human T41 449366 ysttPGGtLFsttPG eIF_4EBP X -MTOR mTOR P42345 human DUSP10 11221 Q9Y6W6 DUSP10 human S230 38520205 DsFKRIFsKEIIVyD Rhodanese X -MTOR mTOR P42345 human UVRAG 7405 Q9P2Y5 UVRAG human S522 471489 QyktPPPsyNSALAQ X -MTOR mTOR P42345 human PRAS40 84335 Q96B36 AKT1S1 human S221 2506802 DLDRIAAsMRALVLR PRAS X -MTOR mTOR P42345 human UVRAG 7405 Q9P2Y5 UVRAG human S508 7447337 KGHRKRAssENERLQ X -MTOR mTOR P42345 human UNK 85451 Q9C0B0 UNK human S359 1880742110 DSVPVsPssPHAPDL X -MTOR mTOR P42345 human GRB10 14783 Q60760 Grb10 mouse S503 455870 MNILSsQsPLHPSTL X 11817 -MTOR mTOR P42345 human DEPTOR 64798 Q8TB45 DEPTOR human S265 4723818 stsFMsVsPsKEIKI X -MTOR mTOR P42345 human PIP4K2C 79837 Q8TBX8 PIP4K2C human S328 34431500 LVGsYGTsPEGIGGY PIP5K X -MTOR mTOR P42345 human Akt1 11651 P31750 Akt1 mouse S473 447855 RPHFPQFsysAsGtA Pkinase_C X X 9271; 3787; 4060; 4051; 5102; 4058; 2336; 2337; 4075; 4070; 5012; 4071; 92982; 5315; 9563; 9018; 12694; 52240; 11962; 15116; 88106; 26580; 68035; 31957; 23430; 20235 -MTOR mTOR P42345 human AMBRA1 55626 Q9C0C7 AMBRA1 human S52 27443426 KRVELPDsPRSTFLL X X -MTOR mTOR P42345 human ANKRD17 26057 O75179 ANKRD17 human S2045 484761 yPVssPssPsPPAQP X -MTOR mTOR P42345 human HSF1 3297 Q00613 HSF1 human S326 455484 ssVDtLLsPTALIDs Vert_HS_TF X X -MTOR mTOR P42345 human UBR4 23352 Q5T4S7 UBR4 human S2932 20622176 GHPAGPGsVsSStGA X -MTOR mTOR P42345 human RUBCNL 80183 Q9H714 RUBCNL human S157 25284922 sPGILATsPYPETDS X X -MTOR mTOR P42345 human SCYL1 57410 Q96KG9 SCYL1 human S754 5208514 sTQPRPDsWGEDNWE X X -MTOR mTOR P42345 human p70S6K iso2 6198 P23443-2 RPS6KB1 human T389 448607 NQVFLGFtYVAPSVL Pkinase_C X X 9209; 97596 -MTOR mTOR P42345 human 4E-BP1 1978 Q13541 EIF4EBP1 human T46 447496 GGtLFsttPGGtRII eIF_4EBP X X 2855; 9459; 2846; 4923; 5123; 3929; 7547; 45613; 39788 -MTOR mTOR P42345 human ZNF768 79724 Q9H5H4 ZNF768 human S139 453883 sPGyEPRsPGyEsES RNA_pol_Rpb1_R X -MTOR mTOR P42345 human SENP3 26168 Q9H4L4 SENP3 human T142 36438200 MLLYsKstsLtFHWK X X -MTOR mTOR P42345 human LARP6 55323 Q9BRS8 LARP6 human S348 54436202 DPESNPTsPMAGRRH X -MTOR mTOR P42345 human S6 6194 P62753 RPS6 human S235 448092 IAKRRRLssLRAsts X 5006; 4856; 4857; 4858; 4851; 4803; 2211; 3945; 3985; 5316; 4854; 8520; 48319; 40643; 9865; 38573; 14733; 27036; 34411; 62016; 62788; 81736; 97935; 99457; 15448 -MTOR mTOR P42345 human NRBF2 29982 Q96F24 NRBF2 human S113 7446822 AEDAEGQsPLsQkYs NRBF2 X X -MTOR mTOR P42345 human MAF1 84232 Q9H063 MAF1 human S75 477954 sPsRLsksQGGEEEG Maf1 X -MTOR mTOR P42345 human NFAT3 73181 Q8K120 Nfatc4 mouse S168 448859 QGGGAFFsPsPGSSS X -MTOR mTOR P42345 human Akt1 11651 P31750 Akt1 mouse T308 447856 KDGAtMKtFCGtPEy Pkinase X X 5106; 2965; 9275; 4056; 5056; 13842; 13038; 43506; 48646; 86758; 80722; 77440; 80556 -MTOR mTOR P42345 human MAF1 84232 Q9H063 MAF1 human S68 3211920 PPQtsGLsPsRLsks Maf1 X X -MTOR mTOR P42345 human APBA3 9546 O96018 APBA3 human T5 29668010 ___MDFPtIsRsPsG X -MTOR mTOR P42345 human UVRAG 7405 Q9P2Y5 UVRAG human S493 7447334 GGADVGFsGGIPsPD X -MTOR mTOR P42345 human PASK 23178 Q96RG2 PASK human S949 14160727 RTRLFLAsLPGstHs X -MTOR mTOR P42345 human PIP4K2C 79837 Q8TBX8 PIP4K2C human S324 34431501 GPPALVGsYGTsPEG PIP5K X -MTOR mTOR P42345 human MST1 58231 Q9JI11 Stk4 mouse S438 4271929 GDyEFLKsWTVEDLQ Mst1_SARAH X -MTOR mTOR P42345 human GRB10 2887 Q13322 GRB10 human T155 22312200 PGsPPVLtPGsLPPS X -MTOR mTOR P42345 human DEPTOR 64798 Q8TB45 DEPTOR human S299 4723878 ssPtLsssPPVLCNP X X -MTOR mTOR P42345 human HOXB13 10481 Q92826 HOXB13 human T8 34606107 MEPGNYAtLDGAKDI X -MTOR mTOR P42345 human mTOR 2475 P42345 MTOR human T2474 458289 AHKKtGttVPEsIHs X -MTOR mTOR P42345 human WNK1 65125 Q9H4A3 WNK1 human S2032 469047 DGsGsPHsPHQLssK X -MTOR mTOR P42345 human LARP 23367 Q6PKG0 LARP1 human S766 483150 EPStIARsLPttVPE X -MTOR mTOR P42345 human PKCE 5581 Q02156 PRKCE human T566 448787 LNGVTTTtFCGTPDy Pkinase X 9379; 2060; 38938 -PRPF4B PRP4 Q13523 human ELK1 2002 P19419 ELK1 human T417 452139 ISVDGLstPVVLsPG X X -PIK3CA PIK3CA P42336 human SMAD2 Q1W668 SMAD2 cow S245 448794 NQSMDTGsPAELsPT X -PIK3CA PIK3CA P42336 human p70S6K 6198 P23443 RPS6KB1 human T412 448607 NQVFLGFtyVAPsVL Pkinase_C X 9206; 9234; 9205; 9209; 97596 -PIK3CA PIK3CA P42336 human SMAD2 Q1W668 SMAD2 cow T220 448793 QSNYIPEtPPPGYIS X -PIK3CA PIK3CA P42336 human PIK3R1 5295 P27986 PIK3R1 human S608 448133 ENtEDQysLVEDDED X X -PIK3CA PIK3CA P42336 human SMAD2 Q1W668 SMAD2 cow S255 448796 ELsPTTLsPVNHSLD X -PIK3CA PIK3CA P42336 human p70S6K 6198 P23443 RPS6KB1 human T252 448606 HDGtVtHtFCGtIEY Pkinase X -PIK3CA PIK3CA P42336 human TPM1 7168 P09493 TPM1 human S61 456510 EDELDkysEALKDAQ Tropomyosin X -PIK3CA PIK3CA P42336 human Akt1 11651 P31750 Akt1 mouse T308 447856 KDGAtMKtFCGtPEy Pkinase X 5106; 2965; 9275; 4056; 5056; 13842; 13038; 43506; 48646; 86758; 80722; 77440; 80556 -PIK3CA PIK3CA P42336 human Akt1 207 P31749 AKT1 human T308 447856 kDGAtMKtFCGtPEy Pkinase X 5106; 2965; 9275; 4056; 5056; 13842; 13038; 43506; 48646; 86758; 80722; 77440; 80556 -Gsk3b GSK3B P18266 rat CTNNB1 84353 Q9WU82 Ctnnb1 rat S45 447488 GATtTAPsLSGkGNP X 9565; 24710; 70034; 19807; 96727; 77605 -Gsk3b GSK3B P18266 rat MAP1B 17755 P14873 Map1b mouse T1265 455476 PPsPIEKtPLGERsV X -Gsk3b GSK3B P18266 rat CTNNB1 84353 Q9WU82 Ctnnb1 rat S33 447487 QQQSYLDsGIHsGAT X X 9561; 2009; 4270; 13537; 41334; 60180 -Gsk3b GSK3B P18266 rat eIF2B-epsilon 192234 Q64350 Eif2b5 rat S535 449905 VDPEELDsRAGsPQL X X -Gsk3b GSK3B P18266 rat Myc 4609 P01106 MYC human T73 448496 kkFELLPtPPLsPsR Myc_N X 46650 -Gsk3b GSK3B P18266 rat Doublecortin 84394 Q9ESI7 Dcx rat S332 451363 STPKSKQsPISTPTs X -Gsk3b GSK3B P18266 rat RCAN1 266766 Q6IN33 Rcan1 rat S108 456022 PDKQFLIsPPAsPPV Calcipressin X -Gsk3b GSK3B P18266 rat PXN 360820 Q66H76 Pxn rat S126 450227 SFPNKQKsAEPsPtV Paxillin X -Gsk3b GSK3B P18266 rat PSD-95 29495 P31016 Dlg4 rat T19 3609101 YRYQDEDtPPLEHSP X -Gsk3b GSK3B P18266 rat CRMP-2 25416 P47942 Dpysl2 rat T514 454386 SVtPKTVtPASsAKT X 9397 -Gsk3b GSK3B P18266 rat SIK 59329 Q9R1U5 Sik1 rat T182 456034 KPGEPLStWCGsPPY Pkinase X X -Gsk3b GSK3B P18266 rat CTNNB1 84353 Q9WU82 Ctnnb1 rat S37 447582 YLDsGIHsGATtTAP X 9561; 2009; 4270; 13537; 41334; 60180 -Gsk3b GSK3B P18266 rat ADD2 24171 Q05764 Add2 rat S598 3147633 EPGsPVKsTPAsPVQ X -Gsk3b GSK3B P18266 rat SIK 59329 Q9R1U5 Sik1 rat S186 2560900 PLStWCGsPPYAAPE Pkinase X -Gsk3b GSK3B P18266 rat CREB iso1 81646 P15337-1 Creb1 rat S129 450092 QKRREILsRRPsYRk pKID X -Gsk3b GSK3B P18266 rat MAP1B 17755 P14873 Map1b mouse S1260 454136 sLsPsPPsPIEKtPL X -Gsk3b GSK3B P18266 rat CRMP-2 25416 P47942 Dpysl2 rat S518 448081 KTVtPASsAKTsPAK X -Gsk3b GSK3B P18266 rat NFH 24587 P16884 Nefh rat S493 455548 GEEAATTsPPAEEAA X -Gsk3b GSK3B P18266 rat ADD2 24171 Q05764 Add2 rat S692 454590 sVTsGPLsPEGsPSK X -Gsk3b GSK3B P18266 rat CTNNB1 84353 Q9WU82 Ctnnb1 rat T41 447583 GIHsGATtTAPsLSG X 9561; 9565; 4270; 13537; 41334; 60180 -Gsk3b GSK3B P18266 rat gephyrin 64845 Q03555 Gphn rat S283 2020113 LSttPsEsPRAQAts X -NEK6 NEK6 Q9HC98 human KIF20A 10112 O95235 KIF20A human S754 114810408 ELQkLGEsLQsAERA X -NEK6 NEK6 Q9HC98 human SGK1 6446 O00141 SGK1 human S377 11507607 PPFNPNVsGPNDLRH Pkinase_C X -NEK6 NEK6 Q9HC98 human BSG iso2 682 P35613-2 BSG human S252 476131 GsAPLKSsGQHQNDK X -NEK6 NEK6 Q9HC98 human DDR1 780 Q08345 DDR1 human S788 11507611 KIADFGMsRNLyAGD PK_Tyr_Ser-Thr X -NEK6 NEK6 Q9HC98 human ACD 65057 Q96AP0 ACD human S169 15407290 sNAGLSLsQLLDEMR X -NEK6 NEK6 Q9HC98 human Rb-like 2 5934 Q08999 RBL2 human S659 11507610 DTGGLGRsItsPttL X -NEK6 NEK6 Q9HC98 human p70S6K 6198 P23443 RPS6KB1 human T412 448607 NQVFLGFtyVAPsVL Pkinase_C X 9206; 9234; 9205; 9209; 97596 -NEK6 NEK6 Q9HC98 human p70S6K 83840 P67999 Rps6kb1 rat T412 448607 NQVFLGFtYVAPSVL Pkinase_C X X 9206; 9234; 9205; 97596 -NEK6 NEK6 Q9HC98 human NUP98 iso2 4928 P52948-2 NUP98 human S591 470431 VLKNLNNsNLFsPVN X -NEK6 NEK6 Q9HC98 human EML4 27436 Q9HC35 EML4 human S144 465781 QsPQIRAsPsPQPss X X -NEK6 NEK6 Q9HC98 human KIF11 3832 P52732 KIF11 human S1033 20798600 GINtLERskVEETTE Microtub_bind X -NEK6 NEK6 Q9HC98 human STAT3 6774 P40763 STAT3 human S727 448191 NtIDLPMsPrTLDSL X X 9134; 9136; 34911; 94994; 49081; 58978; 87544; 71958; 50804 -NEK6 NEK6 Q9HC98 human STAT3 6774 P40763 STAT3 human Y705 448192 DPGsAAPyLktKFIC X 4093; 9145; 4324; 9131; 9138; 4323; 4074; 4113; 48313; 20977; 25023; 8119; 52075; 52527; 73533; 61958; 73452; 16185; 74309 -NEK6 NEK6 Q9HC98 human KIF20A 10112 O95235 KIF20A human S683 12667657 RsQRLAAsAstQQLQ X -NEK6 NEK6 Q9HC98 human NMDAR1 2902 Q05586 GRIN1 human S890 447737 ITSTLASsFKRRRss X 3381 -NEK6 NEK6 Q9HC98 human KIF20A 10112 O95235 KIF20A human S883 4712600 RRsPLLKsGPFGKKY X -NEK6 NEK6 Q9HC98 human p70S6K 6198 P23443 RPS6KB1 human S403 11507608 DDStLSEsANQVFLG Pkinase_C X -NEK6 NEK6 Q9HC98 human p70S6K 6198 P23443 RPS6KB1 human S53 11507609 EGGQLNEsMDHGGVG X -NEK6 NEK6 Q9HC98 human KIF20A 10112 O95235 KIF20A human S240 31855501 QEEELSTsLkRsVyI Kinesin X -NEK6 NEK6 Q9HC98 human SGK1 6446 O00141 SGK1 human S422 448429 AEAFLGFsYAPPTDS Pkinase_C X -NEK6 NEK6 Q9HC98 human PSMD2 5708 Q13200 PSMD2 human S361 487471 ENNrFGGsGsQVDsA X -NEK6 NEK6 Q9HC98 human CDK7 1022 P50613 CDK7 human S161 2192636 ADFGLAksFGsPNRA Pkinase X -NEK6 NEK6 Q9HC98 human KIF20A 10112 O95235 KIF20A human S244 459830 LSTsLkRsVyIEsRI Kinesin X -NEK6 NEK6 Q9HC98 human HSP70 3303 P0DMV8 HSPA1B human T66 31882985 VALNPQNtVFDAkRL HSP70 X X -NEK6 NEK6 Q9HC98 human ERCC2 2068 P18074 ERCC2 human T425 1878257800 IEPFDDRtPTIANPI X X -NEK6 NEK6 Q9HC98 human NUP98 iso2 4928 P52948-2 NUP98 human S822 3150833 TSRCLIKsPDRLADI Nucleoporin2 X -CSNK1A1 CK1A P48729 human SLC4A1 6521 P02730 SLC4A1 human S303 451406 IDAYMAQsRGELLHS Band_3_cyto X -CSNK1A1 CK1A P48729 human FOXG1 2290 P55316 FOXG1 human S19 482880 MIPKSSFsINSLVPE X X -CSNK1A1 CK1A P48729 human 14-3-3 theta 10971 P27348 YWHAQ human S232 456053 LTLWtsDsAGEECDA X X -CSNK1A1 CK1A P48729 human TDP-43 23435 Q13148 TARDBP human S379 3084615 NSYsGsNsGAAIGWG X -CSNK1A1 CK1A P48729 human FOXO4 4303 P98177 FOXO4 human S268 231166708 ssNAsSVsTRLsPLR X X -CSNK1A1 CK1A P48729 human TDP-43 23435 Q13148 TARDBP human S393 6855908 GsAsNAGsGsGFNGG X -CSNK1A1 CK1A P48729 human CARD11 84433 Q9BXL7 CARD11 human S615 5403700 RYSFGPSsIHSSSSS X -CSNK1A1 CK1A P48729 human ATF-1 466 P18846 ATF1 human S47 15725601 EsQDSSDsIGssQKA pKID X -CSNK1A1 CK1A P48729 human SLC18A2 25549 Q01827 Slc18a2 rat S514 465596 GDDEEsEsD______ X -CSNK1A1 CK1A P48729 human NFM P16053 NEFM chicken S471 22689704 sEMEDALsAIAEEMA X -CSNK1A1 CK1A P48729 human GJA1 24392 P08050 Gja1 rat S325 449992 NRMGQAGstIsNsHA Connexin43 X X -CSNK1A1 CK1A P48729 human SNCA 6622 P37840 SNCA human T64 1876998407 EktkEQVtNVGGAVV Synuclein X X -CSNK1A1 CK1A P48729 human HSP70 3303 P0DMV8 HSPA1B human T636 18010647 GGsGsGPtIEEVD__ X -CSNK1A1 CK1A P48729 human p53 7157 P04637 TP53 human S37 447532 NVLsPLPsQAMDDLM TAD2 X 9289 -CSNK1A1 CK1A P48729 human TDP-43 23435 Q13148 TARDBP human S387 6855913 GAAIGWGsAsNAGsG X -CSNK1A1 CK1A P48729 human DARPP-32 360616 Q6J4I0 Ppp1r1b rat S137 448046 EEDEEEDsQAEVLKG DARPP-32 X -CSNK1A1 CK1A P48729 human JADE1 79960 Q6IE81 JADE1 human S18 35530402 EDsDDNGsLsTTWSQ EPL1 X X -CSNK1A1 CK1A P48729 human BACE 23621 P56817 BACE1 human S498 450178 DDFADDIsLLk____ X -CSNK1A1 CK1A P48729 human CTPS2 56474 Q9NRF8 CTPS2 human S568 3213615 LsSsDrysDAsDDsF X X -CSNK1A1 CK1A P48729 human galectin-3 3958 P17931 LGALS3 human S12 451567 FsLHDALsGSGNPNP X -CSNK1A1 CK1A P48729 human CTNNB1 84353 Q9WU82 Ctnnb1 rat S45 447488 GATtTAPsLSGkGNP X 9565; 24710; 70034; 19807; 96727; 77605 -CSNK1A1 CK1A P48729 human TDP-43 23435 Q13148 TARDBP human T116 6855901 LGLPWkTtEQDLkEY RRM_1 X -CSNK1A1 CK1A P48729 human MALT1 10892 Q9UDY8 MALT1 human S573 1869465811 GTEYsAEsLVRNLQW Peptidase_C14 X -CSNK1A1 CK1A P48729 human BID 637 P55957 BID human S64 1880042000 LQtDGNRsSHsRLGR X -CSNK1A1 CK1A P48729 human ERG 2078 P11308 ERG human S38 50259802 TEMTASsssDyGQTs X -CSNK1A1 CK1A P48729 human APC 324 P25054 APC human S1507 452097 FsCsssLsALsLDEP APC_r X -CSNK1A1 CK1A P48729 human AGO2 27161 Q9UKV8 AGO2 human S831 7104887 sAEGsHtsGQsNGRD X X -CSNK1A1 CK1A P48729 human TBX21 57765 Q9JKD8 Tbx21 mouse S508 458229 PsSGDSSsPAGAPsP X -CSNK1A1 CK1A P48729 human CREB 1385 P16220 CREB1 human S142 451886 PRIEEEKsEEETSAP X -CSNK1A1 CK1A P48729 human HSP90B 3326 P08238 HSP90AB1 human S718 3177650 LEGDEDAsRMEEVD_ X -CSNK1A1 CK1A P48729 human CREM 12916 P27699 Crem mouse S113 450059 TIAEtDDsADsEVID pKID X -CSNK1A1 CK1A P48729 human VHL 7428 P40337 VHL human S72 469117 SVNsREPsQVIFCNr VHL X -CSNK1A1 CK1A P48729 human SQSTM1 8878 Q13501 SQSTM1 human S349 14580829 sskEVDPstGELQsL X X 95697; 16177; 12074 -CSNK1A1 CK1A P48729 human ATF-1 466 P18846 ATF1 human S36 465558 AQQVSSLsESEEsQD X -CSNK1A1 CK1A P48729 human SNCA 20617 O55042 Snca mouse T64 1876998407 EKtKEQVtNVGGAVV Synuclein X X -CSNK1A1 CK1A P48729 human GJC1 14615 P28229 Gjc1 mouse S382 22598807 KSGSNKssIssKsGD X -CSNK1A1 CK1A P48729 human ATM 472 Q13315 ATM human S1270 1881548600 SHFDEVksIANQIQE X X -CSNK1A1 CK1A P48729 human PHLPP 23239 O60346 PHLPP1 human S1379 22769302 GSKGLWDsLsVEEAV PP2C X -CSNK1A1 CK1A P48729 human IFNAR1 3454 P17181 IFNAR1 human S535 454418 SSQTsQDsGNysNED X -CSNK1A1 CK1A P48729 human p53 7157 P04637 TP53 human T18 447541 EPPLsQEtFsDLWkL P53_TAD X 2529 -CSNK1A1 CK1A P48729 human NLRP3 114548 Q96P20 NLRP3 human S806 1877558200 KLVELDLsDNALGDF LRR_6 X -CSNK1A1 CK1A P48729 human CREB 1385 P16220 CREB1 human S100 451809 EsEDsQEsVDsVtDs pKID X X -CSNK1A1 CK1A P48729 human CREM 12916 P27699 Crem mouse S121 450061 ADsEVIDsHKRREIL pKID X -CSNK1A1 CK1A P48729 human Myc 4609 P01106 MYC human S267 466014 PPTtssDsEEEQEDE Myc_N X -CSNK1A1 CK1A P48729 human CTNNB1 1499 P35222 CTNNB1 human S45 447488 GATtTAPsLsGkGNP X X 9565; 9564; 24710; 70034; 19807; 96727; 77605 -CSNK1A1 CK1A P48729 human NFM P16053 NEFM chicken S502 1868948300 AVEEEAVsEKAAEQA X -CSNK1A1 CK1A P48729 human SLC4A1 6521 P02730 SLC4A1 human T42 451405 AAHDtEAtAtDyHtt X -CSNK1A1 CK1A P48729 human p53 22059 P02340 Tp53 mouse S12 447538 EEsQsDIsLELPLsQ P53_TAD X -CSNK1A1 CK1A P48729 human RHOB 388 P62745 RHOB human S185 2853110 ALQkRYGsQNGCINC X X -CSNK1A1 CK1A P48729 human RBM21 64852 Q9H6E5 TUT1 human S6 31080908 __MAAVDsDVEsLPr X X -CSNK1A1 CK1A P48729 human ERG 2078 P11308 ERG human S39 50259800 EMTASsssDyGQTsK X -CSNK1A1 CK1A P48729 human TDP-43 23435 Q13148 TARDBP human T25 6855922 IPSEDDGtVLLSTVT TDP43_N X -CSNK1A1 CK1A P48729 human LRP6 4040 O75581 LRP6 human S1490 456289 AILNPPPsPAtERsH X 2568 -CSNK1A1 CK1A P48729 human 14-3-3 zeta 7534 P63104 YWHAZ human T232 449846 LTLWtsDtQGDEAEA X -CSNK1A1 CK1A P48729 human GJA1 2697 P17302 GJA1 human S325 449992 NRMGQAGstIsNsHA Connexin43 X -CSNK1A1 CK1A P48729 human DEPTOR 64798 Q8TB45 DEPTOR human T149 21697916 kLMsPENtLLQPREE DEP X -CSNK1A1 CK1A P48729 human TDP-43 23435 Q13148 TARDBP human S2 6855903 ______MsEyIRVtE X -CSNK1A1 CK1A P48729 human ZRANB1 54764 Q9UGI0 ZRANB1 human S209 23077543 RWRGsCssGNsQRRS X X -CSNK1A1 CK1A P48729 human TDP-43 23435 Q13148 TARDBP human S409 3084616 GssMDskssGWGM__ X -CSNK1A1 CK1A P48729 human GYS1 100008660 P13834 GYS1 rabbit S11 451605 SRTLsVSsLPGLEDW X -CSNK1A1 CK1A P48729 human EIF6 3692 P56537 EIF6 human S175 17535703 EDQDELssLLQVPLV eIF-6 X -CSNK1A1 CK1A P48729 human TDP-43 23435 Q13148 TARDBP human S242 6855910 ADDQIAQsLCGEDLI RRM_1 X -CSNK1A1 CK1A P48729 human AHCYL1 229709 Q80SW1 Ahcyl1 mouse S74 467246 IsQsstDsySsAAsy X -CSNK1A1 CK1A P48729 human PHLPP 23239 O60346 PHLPP1 human T1363 22769303 HVQsVLLtPQDEFFI PP2C X -CSNK1A1 CK1A P48729 human ERG 2078 P11308 ERG human S37 50259801 KTEMTASsssDyGQT X -CSNK1A1 CK1A P48729 human GJA1 2697 P17302 GJA1 human S328 449993 GQAGstIsNsHAQPF Connexin43 X -CSNK1A1 CK1A P48729 human CDC25A 993 P30304 CDC25A human S82 450248 GssEstDsGFCLDsP X X -CSNK1A1 CK1A P48729 human galectin-3 373917 A4GTP0 LGALS3 chicken S6 450131 __MSDGFsLsDALPA X -CSNK1A1 CK1A P48729 human AHCYL1 229709 Q80SW1 Ahcyl1 mouse S68 467244 RSLSRsIsQsstDsy X -CSNK1A1 CK1A P48729 human ECE1 1889 P42892 ECE1 human S36 3053606 EDLVDsLsEGDAyPN X -CSNK1A1 CK1A P48729 human TDP-43 23435 Q13148 TARDBP human S407 6855919 GFGssMDskssGWGM X -CSNK1A1 CK1A P48729 human APC 324 P25054 APC human S1510 999606 sssLsALsLDEPFIQ X -CSNK1A1 CK1A P48729 human GJA1 24392 P08050 Gja1 rat S330 449994 AGstIsNsHAQPFDF Connexin43 X X -CSNK1A1 CK1A P48729 human CTNND1 iso3 1500 O60716-3 CTNND1 human S268 450453 PQVRVGGssVDLHRF X -CSNK1A1 CK1A P48729 human TDP-43 23435 Q13148 TARDBP human S254 6855920 DLIIKGIsVHISNAE X -CSNK1A1 CK1A P48729 human OSBP2 23762 Q969R2 OSBP2 human S762 11171320 ECSKVMHssPssPsS Oxysterol_BP X -CSNK1A1 CK1A P48729 human FOXO1A 2308 Q12778 FOXO1 human S322 449112 PRtssNAstIsGRLs X -CSNK1A1 CK1A P48729 human SRPK2 6733 P78362 SRPK2 human S497 483632 SRtVsAsstGDLPkA X 23708; 96446 -CSNK1A1 CK1A P48729 human NFAT4 4775 Q12968 NFATC3 human T204 11507601 NEAAARFtLGsPLts X X -CSNK1A1 CK1A P48729 human NFAT5 10725 O94916 NFAT5 human S158 2715403 LLDNsRMsCQDEGCG X -CSNK1A1 CK1A P48729 human APC 324 P25054 APC human S1504 999604 PDGFsCsssLsALsL APC_r X -CSNK1A1 CK1A P48729 human p53 22059 P02340 Tp53 mouse S7 448716 _MTAMEEsQsDIsLE X -CSNK1A1 CK1A P48729 human hnRNP C1/C2 3183 P07910 HNRNPC human S260 448833 sEGGADDsAEEGDLL X X -CSNK1A1 CK1A P48729 human p53 22059 P02340 Tp53 mouse S9 447537 TAMEEsQsDIsLELP P53_TAD X 9285 -CSNK1A1 CK1A P48729 human OSBP2 23762 Q969R2 OSBP2 human S766 15721694 VMHssPssPsSDGKQ Oxysterol_BP X -CSNK1A1 CK1A P48729 human ECE1 1889 P42892 ECE1 human S34 3053605 DEEDLVDsLsEGDAy X -CSNK1A1 CK1A P48729 human TDP-43 23435 Q13148 TARDBP human S305 6855916 GLGNNQGsNMGGGMN X -CSNK1A1 CK1A P48729 human Myc 4609 P01106 MYC human S82 4967400 PLsPsRRsGLCsPSy Myc_N X -CSNK1A1 CK1A P48729 human BID 637 P55957 BID human S67 14570494 DGNRsSHsRLGRIEA BID X -CSNK1A1 CK1A P48729 human FOXO4 4303 P98177 FOXO4 human S265 231166707 PRSssNAsSVsTRLs X X -CSNK1A1 CK1A P48729 human SLC18A2 25549 Q01827 Slc18a2 rat S512 465595 PIGDDEEsEsD____ X -CSNK1A1 CK1A P48729 human RORA 6095 P35398 RORA human S100 1212279800 CKGFFRRsQQSNATY zf-C4 X X -CSNK1A1 CK1A P48729 human SNCA 6622 P37840 SNCA human S87 449948 ktVEGAGsIAAATGF Synuclein X -CSNK1A1 CK1A P48729 human ATF-1 466 P18846 ATF1 human S51 15725602 SSDsIGssQKAHGIL pKID X -CSNK1A1 CK1A P48729 human SNCA 6622 P37840 SNCA human S129 448278 NEAyEMPsEEGyQDy Synuclein X X 23706; 87281 -CSNK1A1 CK1A P48729 human TDP-43 23435 Q13148 TARDBP human T88 6855904 NKRkMDEtDAssAVk X -CSNK1A1 CK1A P48729 human GJC1 14615 P28229 Gjc1 mouse S393 22598810 KsGDGKTsVWI____ X -CSNK1A1 CK1A P48729 human GJA1 2697 P17302 GJA1 human S330 449994 AGstIsNsHAQPFDF Connexin43 X -CSNK1A1 CK1A P48729 human FAK iso5 396416 Q92063 PTK2 chicken S151 447963 DVRLsRGsIEREDGG X -CSNK1A1 CK1A P48729 human MDM4 4194 O15151 MDM4 human S289 456471 DDLEDSKsLSDDTDV X X -CSNK1A1 CK1A P48729 human calsenilin 30818 Q9Y2W7 KCNIP3 human S63 450214 APQGSDSsDSELELS X -CSNK1A1 CK1A P48729 human MCR 4306 P08235 NR3C2 human T800 1875398904 LPLEDQItLIQYSWM Hormone_recep X X -CSNK1A1 CK1A P48729 human TDP-43 23435 Q13148 TARDBP human S410 3084601 ssMDskssGWGM___ X -CSNK1A1 CK1A P48729 human RAPGEF2 9693 Q9Y4G8 RAPGEF2 human S1248 30995200 AADsGRGsWTSCSsG X X -CSNK1A1 CK1A P48729 human galectin-3 3958 P17931 LGALS3 human S6 450131 __MADNFsLHDALsG X X -CSNK1A1 CK1A P48729 human TIAM1 7074 Q13009 TIAM1 human S329 23152631 DVNAGEGsEFADsGI X -CSNK1A1 CK1A P48729 human NFAT4 4775 Q12968 NFATC3 human S211 11507600 tLGsPLtsPGGsPGG X X -CSNK1A1 CK1A P48729 human CTNND1 iso3 1500 O60716-3 CTNND1 human S269 470326 QVRVGGssVDLHRFH X -CSNK1A1 CK1A P48729 human TDP-43 23435 Q13148 TARDBP human S347 6855906 LAsQQNQsGPsGNNQ X -CSNK1A1 CK1A P48729 human CDH1 999 P12830 CDH1 human S844 478354 GsGsEAAsLSsLNsS CADH_Y-type_LIR X -CSNK1A1 CK1A P48729 human CREM 12916 P27699 Crem mouse S116 450060 EtDDsADsEVIDsHK pKID X -CSNK1A1 CK1A P48729 human CREB 1385 P16220 CREB1 human S97 451808 TIAEsEDsQEsVDsV X -CSNK1A1 CK1A P48729 human ZRANB1 54764 Q9UGI0 ZRANB1 human T35 50840530 RAQRPSGtIItEDPF X X -CSNK1A1 CK1A P48729 human AGO2 27161 Q9UKV8 AGO2 human S834 40509024 GsHtsGQsNGRDHQA X X -CSNK1A1 CK1A P48729 human TDP-43 23435 Q13148 TARDBP human S395 6855914 AsNAGsGsGFNGGFG X -CSNK1A1 CK1A P48729 human TDP-43 23435 Q13148 TARDBP human S273 6855912 SNRQLERsGrFGGNP X -CSNK1A1 CK1A P48729 human PARK2 5071 O60260 PRKN human S378 454424 AyHEGECsAVFEASG X -CSNK1A1 CK1A P48729 human LRP6 4040 O75581 LRP6 human T1493 466015 NPPPsPAtERsHytM X X -CSNK1A1 CK1A P48729 human CBX4 8535 O00257 CBX4 human T437 7315202 ARsIsTPtCLGGsPA X X -CSNK1A1 CK1A P48729 human FOXO1A 2308 Q12778 FOXO1 human S325 449114 ssNAstIsGRLsPIM X -CSNK1A1 CK1A P48729 human RAPGEF2 9693 Q9Y4G8 RAPGEF2 human S1244 30995201 ASLDAADsGRGsWTS X X -CSNK1A1 CK1A P48729 human AHCYL1 229709 Q80SW1 Ahcyl1 mouse S71 467245 SRsIsQsstDsySsA X -CSNK1A1 CK1A P48729 human TDP-43 23435 Q13148 TARDBP human S403 3084617 GFNGGFGssMDskss X -CSNK1A1 CK1A P48729 human FADD 8772 Q13158 FADD human S194 447653 QNRsGAMsPMsWNsD X 2781 -CSNK1A1 CK1A P48729 human MCR 4306 P08235 NR3C2 human S936 1875398906 DSMHDLVsDLLEFCF Hormone_recep X -CSNK1A1 CK1A P48729 human galectin-3 373917 A4GTP0 LGALS3 chicken S8 18575500 MSDGFsLsDALPAHN X -CSNK1A1 CK1A P48729 human BID 12122 P70444 Bid mouse S61 448404 DELQtDGsQAsRsFN BID X -CSNK1A1 CK1A P48729 human hnRNP C1/C2 3183 P07910 HNRNPC human S253 448835 EtNVkMEsEGGADDs X X -CSNK1A1 CK1A P48729 human DEPTOR 64798 Q8TB45 DEPTOR human S287 4723848 sMssCGssGyFsssP X X -CSNK1A1 CK1A P48729 human NFkB-p65 5970 Q04206 RELA human S316 31880654 FksIMkksPFsGPtD X -CSNK1A1 CK1A P48729 human CDK5 1020 Q00535 CDK5 human S159 448021 GIPVRCYsAEVVTLW Pkinase X -CSNK1A1 CK1A P48729 human HSP90A 3320 P07900 HSP90AA1 human S726 3180213 LEGDDDtsRMEEVD_ X -CSNK1A1 CK1A P48729 human TDP-43 23435 Q13148 TARDBP human S375 6855909 GsGNNSYsGsNsGAA X -CSNK1A1 CK1A P48729 human CTNNB1 12387 Q02248 Ctnnb1 mouse S45 447488 GATtTAPsLsGkGNP X X 9565; 9564; 24710; 70034; 19807; 96727; 77605 -CSNK1A1 CK1A P48729 human p53 22059 P02340 Tp53 mouse T21 447541 ELPLsQEtFsGLWKL P53_TAD X -CSNK1A1 CK1A P48729 human TDP-43 23435 Q13148 TARDBP human S404 3084635 FNGGFGssMDskssG X -CSNK1A1 CK1A P48729 human ATF-1 466 P18846 ATF1 human S41 15725600 SLsESEEsQDSSDsI X -CSNK1A1 CK1A P48729 human HSP90A 3320 P07900 HSP90AA1 human T725 3180216 PLEGDDDtsRMEEVD X -CSNK1A1 CK1A P48729 human p53 7157 P04637 TP53 human S20 447529 PLsQEtFsDLWkLLP P53_TAD X X 9287 -CSNK1A1 CK1A P48729 human JADE1 79960 Q6IE81 JADE1 human S20 35530401 sDDNGsLsTTWSQNS EPL1 X X -CSNK1A1 CK1A P48729 human GJC1 14615 P28229 Gjc1 mouse S387 22598806 KssIssKsGDGKTsV X -CSNK1A1 CK1A P48729 human NFM P16053 NEFM chicken S464 18012945 TKVEDEKsEMEDALs X -CSNK1A1 CK1A P48729 human eIF2B-epsilon 192234 Q64350 Eif2b5 rat S464 449997 DGQFsDDsGADQEKE X -CSNK1A1 CK1A P48729 human DEPTOR 64798 Q8TB45 DEPTOR human S286 21697912 ssMssCGssGyFsss X X -CSNK1A1 CK1A P48729 human TDP-43 23435 Q13148 TARDBP human S91 6855905 kMDEtDAssAVkVKR X -CSNK1A1 CK1A P48729 human NFAT4 4775 Q12968 NFATC3 human S215 11507604 PLtsPGGsPGGCPGE X X -CSNK1A1 CK1A P48729 human TDP-43 23435 Q13148 TARDBP human S389 6855917 AIGWGsAsNAGsGsG X -CSNK1A1 CK1A P48729 human OSBP2 23762 Q969R2 OSBP2 human S768 15721697 HssPssPsSDGKQKT Oxysterol_BP X -CSNK1A1 CK1A P48729 human ATF-1 466 P18846 ATF1 human S50 15725603 DSSDsIGssQKAHGI pKID X -CSNK1A1 CK1A P48729 human LRP6 4040 O75581 LRP6 human S1607 21241903 HLYPPPPsPCTDss_ X -CSNK1A1 CK1A P48729 human TDP-43 23435 Q13148 TARDBP human S292 6855918 NQGGFGNsrGGGAGL X -CSNK1A1 CK1A P48729 human UVRAG 7405 Q9P2Y5 UVRAG human S522 471489 QyktPPPsyNSALAQ X X -CSNK1A1 CK1A P48729 human AGO2 27161 Q9UKV8 AGO2 human S828 31082605 EHDsAEGsHtsGQsN X X -CSNK1A1 CK1A P48729 human YB-1 4904 P67809 YBX1 human S176 470445 EkNEGsEsAPEGQAQ X -CSNK1A1 CK1A P48729 human GJC1 14615 P28229 Gjc1 mouse S384 22598805 GSNKssIssKsGDGK X -CSNK1A1 CK1A P48729 human PHLPP 23239 O60346 PHLPP1 human S1359 22769300 VPRPHVQsVLLtPQD PP2C X -CSNK1A1 CK1A P48729 human AGO2 27161 Q9UKV8 AGO2 human S824 27443092 LVDKEHDsAEGsHts X X -CSNK1A1 CK1A P48729 human hnRNP C1/C2 3183 P07910 HNRNPC human S299 448834 EGEDDRDsANGEDDs X X -CSNK1A1 CK1A P48729 human TDP-43 23435 Q13148 TARDBP human S92 6855902 MDEtDAssAVkVKRA X -CSNK1A1 CK1A P48729 human APC 324 P25054 APC human S1505 452096 DGFsCsssLsALsLD APC_r X -CSNK1A1 CK1A P48729 human NFAT4 4775 Q12968 NFATC3 human S207 11507602 AARFtLGsPLtsPGG X X -CSNK1A1 CK1A P48729 human GJC1 14615 P28229 Gjc1 mouse S326 15499912 AQEQQYGsHEEHLPA X -CSNK1A1 CK1A P48729 human LRP6 4040 O75581 LRP6 human T1572 3802448 EPVPPPPtPRsQyLs X -CSNK1A1 CK1A P48729 human NFM P16053 NEFM chicken S528 448043 EEEEAAKsDAAEEGG X -CSNK1A1 CK1A P48729 human FMR1 14265 P35922 Fmr1 mouse S499 469583 NSEAsNAsETESDHR FXMRP1_C_core X -CSNK1A1 CK1A P48729 human OSBP2 23762 Q969R2 OSBP2 human S763 31727226 CSKVMHssPssPsSD Oxysterol_BP X -CSNK1A1 CK1A P48729 human STX1A 116470 P32851 Stx1a rat T21 451260 sDDDDDVtVtVDRDR X -CSNK1A1 CK1A P48729 human TDP-43 23435 Q13148 TARDBP human S342 6855921 GMMGMLAsQQNQsGP X -CSNK1A1 CK1A P48729 human CREM 12916 P27699 Crem mouse S156 450064 PKIEEEKsEEEGTPP X -CSNK1A1 CK1A P48729 human GJA1 24392 P08050 Gja1 rat S328 449993 GQAGstIsNsHAQPF Connexin43 X X -CSNK1A1 CK1A P48729 human EIF6 3692 P56537 EIF6 human S174 17535702 IEDQDELssLLQVPL eIF-6 X -CSNK1A1 CK1A P48729 human DEPTOR 64798 Q8TB45 DEPTOR human S263 7101486 RKstsFMsVsPsKEI X -CSNK1A1 CK1A P48729 human TDP-43 23435 Q13148 TARDBP human S183 4769419 kLPNskQsQDEPLRS X -CSNK1A1 CK1A P48729 human LSD1 23028 O60341 KDM1A human S687 57786403 HVGsTTAsRGELFLF Amino_oxidase X -CSNK1A1 CK1A P48729 human PHLPP 23239 O60346 PHLPP1 human S1381 22769301 KGLWDsLsVEEAVEA PP2C X -CSNK1A1 CK1A P48729 human PARK2 5071 O60260 PRKN human S101 454420 GCEREPQsLTRVDLs X -CSNK1A1 CK1A P48729 human TDP-43 23435 Q13148 TARDBP human Y4 6855900 ____MsEyIRVtEDE TDP43_N X -CSNK1A1 CK1A P48729 human NFAT4 4775 Q12968 NFATC3 human T210 11507603 FtLGsPLtsPGGsPG X X -CSNK1A1 CK1A P48729 human TDP-43 23435 Q13148 TARDBP human S369 6855907 EPNQAFGsGNNSYsG X -CSNK1A1 CK1A P48729 human CDC25A 993 P30304 CDC25A human S79 450247 QRMGssEstDsGFCL X X -CSNK1A1 CK1A P48729 human TDP-43 23435 Q13148 TARDBP human S377 6855915 GNNSYsGsNsGAAIG X -CSNK1A1 CK1A P48729 human BHLHB2 8553 O14503 BHLHE40 human S243 36324900 GSDTDTDsGYGGESE X X -CSNK1A1 CK1A P48729 human DEPTOR 64798 Q8TB45 DEPTOR human S291 4723858 CGssGyFsssPtLss X -CSNK1A1 CK1A P48729 human CREB 1385 P16220 CREB1 human S94 451807 QISTIAEsEDsQEsV X -CSNK1A1 CK1A P48729 human AGO2 27161 Q9UKV8 AGO2 human T830 62849200 DsAEGsHtsGQsNGR X X -CSNK1A1 CK1A P48729 human DACT1 59036 Q8R4A3 Dact1 mouse S704 1833062500 GDSESSVsEGDFVGE Dapper X -CSNK1A1 CK1A P48729 human TDP-43 23435 Q13148 TARDBP human S350 6855911 QQNQsGPsGNNQNQG X -CSNK1A1 CK1A P48729 human GYS1 100008660 P13834 GYS1 rabbit S8 449898 MPLSRTLsVSsLPGL X -RIPK1 RIPK1 Q13546 human RIPK1 8737 Q13546 RIPK1 human S15 20536002 NVIKMkssDFLEsAE X -RIPK1 RIPK1 Q13546 human RIPK1 8737 Q13546 RIPK1 human S166 27116401 LAsFkMWskLNNEEH PK_Tyr_Ser-Thr X X 65746; 44590; 96323 -RIPK1 RIPK1 Q13546 human DAB2IP 153090 Q5VWQ8 DAB2IP human S728 478274 PsPARsSsYSEANEP DUF3498 X -RIPK1 RIPK1 Q13546 human RIPK1 8737 Q13546 RIPK1 human S14 20536000 LNVIKMkssDFLEsA X 53487 -RIPK1 RIPK1 Q13546 human RIPK1 8737 Q13546 RIPK1 human S20 27116400 kssDFLEsAELDsGG PK_Tyr_Ser-Thr X -RIPK1 RIPK1 Q13546 human RIPK1 19766 Q60855 Ripk1 mouse S166 27116401 VAsFKTWsKLtKEKD PK_Tyr_Ser-Thr X 31122; 53286 -RIPK1 RIPK1 Q13546 human RIPK1 8737 Q13546 RIPK1 human S161 20536001 IADLGLAsFkMWskL PK_Tyr_Ser-Thr X -RIPK1 RIPK1 Q13546 human STAT1 20846 P42225 Stat1 mouse S727 447753 tDNLLPMsPEEFDEM STAT1_TAZ2bind X 9177; 8826; 62390 -Cdk2 CDK2 P97377 mouse MyoD 17927 P10085 Myod1 mouse S200 40684505 SGDSDASsPRsNCSD Myf5 X -Cdk2 CDK2 P97377 mouse B-Myb 17865 P48972 Mybl2 mouse T524 450112 DNtPHtPtPFKNALE Cmyb_C X -Cdk2 CDK2 P97377 mouse FOXO1A 2308 Q12778 FOXO1 human S249 471071 EGGkSGksPrRrAAs X -Cdk2 CDK2 P97377 mouse NRF1 4899 Q16656 NRF1 human S102 1868914505 HVFEsNPsIRKRQQT Nrf1_DNA-bind X -Cdk2 CDK2 P97377 mouse CTNNB1 84353 Q9WU82 Ctnnb1 rat S45 447488 GATtTAPsLSGkGNP X 9565; 24710; 70034; 19807; 96727; 77605 -Cdk2 CDK2 P97377 mouse B-Myb 17865 P48972 Mybl2 mouse T447 452026 NSLtPKStPVkTLPF X -Cdk2 CDK2 P97377 mouse B-Myb 17865 P48972 Mybl2 mouse S581 450115 RKPGLRRsPIKKVRK Cmyb_C X -Cdk2 CDK2 P97377 mouse CTNNB1 84353 Q9WU82 Ctnnb1 rat S33 447487 QQQSYLDsGIHsGAT X 9561; 2009; 4270; 13537; 41334; 60180 -Cdk2 CDK2 P97377 mouse GANP 54387 Q9WUU9 Mcm3ap mouse S502 448619 FWHKKKIsPSKKLFP X -Cdk2 CDK2 P97377 mouse CIZ1 68379 Q8VEH2 Ciz1 mouse T192 22648005 ARtPSSttPNRKDSS X -Cdk2 CDK2 P97377 mouse FOXO1A 2308 Q12778 FOXO1 human S298 471972 QFskWPAsPGsHsND X -Cdk2 CDK2 P97377 mouse MDM2 17246 P23804 Mdm2 mouse T216 450150 SSSESTEtPSHQDLD X -Cdk2 CDK2 P97377 mouse Rb 5925 P06400 RB1 human S795 447979 sPykFPssPLrIPGG Rb_C X 9301 -Cdk2 CDK2 P97377 mouse SOX2 20674 P48432 Sox2 mouse S39 18913847 TGGNQkNsPDRVKRP X -Cdk2 CDK2 P97377 mouse B-Myb 17865 P48972 Mybl2 mouse S396 449253 RGELIPIsPSTEFGG X -Cdk2 CDK2 P97377 mouse C/EBP-beta 1051 P17676 CEBPB human S76 456166 HERAIDFsPyLEPLG X -Cdk2 CDK2 P97377 mouse UBF 21429 P25976 Ubtf mouse S484 450180 DRGKLPEsPKRAEEI HMG_box_5 X -Cdk2 CDK2 P97377 mouse B-Myb 17865 P48972 Mybl2 mouse T408 450108 FGGSGIGtPPSVLKR X -Cdk2 CDK2 P97377 mouse SMAD3 4088 P84022 SMAD3 human T179 451177 PQSNIPEtPPPGYLS X -Cdk2 CDK2 P97377 mouse SMAD3 4088 P84022 SMAD3 human S213 451180 NLsPNPMsPAHNNLD X -Cdk2 CDK2 P97377 mouse B-Myb 17865 P48972 Mybl2 mouse T522 450111 SMDNtPHtPtPFKNA Cmyb_C X -Cdk2 CDK2 P97377 mouse p27Kip1 1027 P46527 CDKN1B human T187 447875 NAGsVEQtPKKPGLR X -Cdk2 CDK2 P97377 mouse NRF1 4899 Q16656 NRF1 human S136 23255800 QAIVLCIsPskPNPV Nrf1_DNA-bind X -Cdk2 CDK2 P97377 mouse CTNNB1 84353 Q9WU82 Ctnnb1 rat S37 447582 YLDsGIHsGATtTAP X 9561; 2009; 4270; 13537; 41334; 60180 -Cdk2 CDK2 P97377 mouse B-Myb 17865 P48972 Mybl2 mouse S283 450113 REYQEFssPEtsLPY X -Cdk2 CDK2 P97377 mouse B-Myb 17865 P48972 Mybl2 mouse S455 450114 PVkTLPFsPSQFLNF Cmyb_C X -Cdk2 CDK2 P97377 mouse STMN1 16765 P54227 Stmn1 mouse S38 448556 sVPdFPLsPPKKKDL Stathmin X 3426; 4191 -Cdk2 CDK2 P97377 mouse E2F5 13559 Q61502 E2f5 mouse T251 448010 SQSSTSVtPQKSTMA X X -Cdk2 CDK2 P97377 mouse CIZ1 68379 Q8VEH2 Ciz1 mouse T191 22648006 QARtPSSttPNRKDS X -Cdk2 CDK2 P97377 mouse CDK7 12572 Q03147 Cdk7 mouse S164 450041 GLAKsFGsPNRAytH Pkinase X -Cdk2 CDK2 P97377 mouse C/EBP-beta 12608 P28033 Cebpb mouse T188 447878 sSssPPGtPSPADAK X X 3084 -Cdk2 CDK2 P97377 mouse B-Myb 17865 P48972 Mybl2 mouse T497 450109 tPLHRDKtPLHQKYP Cmyb_C X -Cdk2 CDK2 P97377 mouse GRASP65 56082 O35254 Gorasp1 rat S277 455582 EQLPGPGsPGHGTAD X -Cdk2 CDK2 P97377 mouse SMAD3 4088 P84022 SMAD3 human T8 452179 MSSILPFtPPIVkRL X -Cdk2 CDK2 P97377 mouse SOX2 20674 P48432 Sox2 mouse S253 6738002 VksEASSsPPVVtSS X 92186 -Cdk2 CDK2 P97377 mouse B-Myb 17865 P48972 Mybl2 mouse T490 452027 SQKVVVTtPLHRDKt Cmyb_C X -Cdk2 CDK2 P97377 mouse B-Myb 17865 P48972 Mybl2 mouse T519 450110 QKYSMDNtPHtPtPF Cmyb_C X -Cdk2 CDK2 P97377 mouse CTNNB1 84353 Q9WU82 Ctnnb1 rat T41 447583 GIHsGATtTAPsLSG X 9561; 9565; 4270; 13537; 41334; 60180 -Cdk2 CDK2 P97377 mouse UBF 21429 P25976 Ubtf mouse S389 450170 INKKQTTsPASKKPS X X -Cdk2 CDK2 P97377 mouse B-Myb 17865 P48972 Mybl2 mouse T267 450107 ADLGEVRtPEPPESL X -Syk Syk Q64725 rat SLP76 155918 Q920L0 Lcp2 rat Y128 448219 DGEDDGDyESPNEEE X -Syk Syk Q64725 rat LAT O70601 Lat rat Y234 448006 DGEEAPDyENLQELN LAT X -CILK1 ICK Q9UPZ9 human BAT3 7917 P46379 BAG6 human T1080 470032 AAGARPLtsPEsLSR X -CILK1 ICK Q9UPZ9 human ICK 56542 Q9JKV2 Cilk1 mouse Y159 456052 SRPPytDyVStRWYR Pkinase X -CILK1 ICK Q9UPZ9 human KIF3A 11127 Q9Y496 KIF3A human T672 33668514 MkLERPRtSKGKARP X -CILK1 ICK Q9UPZ9 human Raptor 57521 Q8N122 RPTOR human T908 23940710 LPSGRPGtTGPAGAQ X X -Cdk5 CDK5 P49615 mouse Tau iso8 4137 P10636-8 MAPT human T231 449079 KKVAVVRtPPKsPss X 20473; 71429 -Cdk5 CDK5 P49615 mouse PIK3C3 225326 Q6PF93 Pik3c3 mouse T159 14659500 DGSEPTRtPGRTssT PI3K_C2 X -Cdk5 CDK5 P49615 mouse GJA1 14609 P23242 Gja1 mouse S282 448854 tAPLsPMsPPGykLV X -Cdk5 CDK5 P49615 mouse PAK1 18479 O88643 Pak1 mouse T212 448176 VIEPLPVtPtRDVAt X X -Cdk5 CDK5 P49615 mouse DRD2 1813 P14416 DRD2 human S321 31010702 GLHSTPDsPAkPEKN 7tm_1 X -Cdk5 CDK5 P49615 mouse Lmr1 iso2 11302 Q80YE4-2 Aatk mouse S34 14364500 ADFSEQGsPAAAAQT X -Cdk5 CDK5 P49615 mouse CHIP 56424 Q9WUD1 Stub1 mouse S20 453857 LGtGGGGsPDksPsA X X -Cdk5 CDK5 P49615 mouse CTNND2 18163 O35927 Ctnnd2 mouse S357 4697626 IGTyATLsPtKRLVH X -Cdk5 CDK5 P49615 mouse RAB3IL1 74760 Q8VDV3 Rab3il1 mouse S169 467058 VItstPAsPNRELHP Sec2p X -Cdk5 CDK5 P49615 mouse DAB1 iso2 13131 P97318-2 Dab1 mouse S481 479420 STtPSTNsPPtPAPR X X -Cdk5 CDK5 P49615 mouse CASK 12361 O70589 Cask mouse S51 1261103 DVAKFTssPGLsTED Pkinase X -Cdk5 CDK5 P49615 mouse SynGAP 240057 F6SEU4 Syngap1 mouse S857 37045603 GPGGRLNsSSVsNLA DUF3498 X -Cdk5 CDK5 P49615 mouse CDK5R1 8851 Q15078 CDK5R1 human T138 471393 PAVTSAGtPKRVIVQ CDK5_activator X -Cdk5 CDK5 P49615 mouse RHOQ 104215 Q8R527 Rhoq mouse T189 5996401 ILTPKKHtVKKRIGS X -Cdk5 CDK5 P49615 mouse ESYT1 23943 Q3U7R1 Esyt1 mouse S314 15409842 QDVAQLRsPLPRGII X -Cdk5 CDK5 P49615 mouse Spinophilin 217124 Q6R891 Ppp1r9b mouse S17 455340 GGPLRsAsPHRSAYE X X -Cdk5 CDK5 P49615 mouse Tau iso8 4137 P10636-8 MAPT human S396 449081 GAEIVyKsPVVsGDt X 9632 -Cdk5 CDK5 P49615 mouse Ezrin 22350 P26040 Ezr mouse T235 449293 YEKDDKLtPkIGFPW FERM_C X X -Cdk5 CDK5 P49615 mouse CRMP-1 1400 Q14194 CRMP1 human T509 454314 PVyEVPAtPKyAtPA X -Cdk5 CDK5 P49615 mouse Tau iso8 4137 P10636-8 MAPT human S404 449082 PVVsGDtsPRHLsNV X 35834; 20194; 98523; 91600; 49562 -Cdk5 CDK5 P49615 mouse RAB3IL1 171452 Q99NH3 Rab3il1 rat S169 467058 VITSTPAsPNRELHP Sec2p X -Cdk5 CDK5 P49615 mouse DAB1 iso3 13131 P97318-3 Dab1 mouse S246 479425 PVSSLVQsPAAERAE X X -Cdk5 CDK5 P49615 mouse SynGAP 240057 F6SEU4 Syngap1 mouse S817 33636339 rPPLARSsPAyCtss DUF3498 X -Cdk5 CDK5 P49615 mouse RAB3IL1 74760 Q8VDV3 Rab3il1 mouse S180 467059 ELHPQLLsPtKAGPR X -Cdk5 CDK5 P49615 mouse DAB1 iso2 13131 P97318-2 Dab1 mouse T470 479418 DISQLNLtPVTSTtP X X -Cdk5 CDK5 P49615 mouse CTNND2 18163 O35927 Ctnnd2 mouse S300 14910701 rGssPKQsPsRLAKS X -Cdk5 CDK5 P49615 mouse JIP1 19099 Q9WVI9 Mapk8ip1 mouse T201 449954 PLKTGEQtPPHEHIC X -Cdk5 CDK5 P49615 mouse SynGAP 240057 F6SEU4 Syngap1 mouse S788 19014968 MDMARLPsPtKEkPP DUF3498 X -Cdk5 CDK5 P49615 mouse P2X2 114115 P49653 P2rx2 rat T372 183815300 KKFDKVRtPKHPSSR X X -Cdk5 CDK5 P49615 mouse SynGAP 240057 F6SEU4 Syngap1 mouse S743 27720871 RQSERTRsQPMVLRG DUF3498 X -Cdk5 CDK5 P49615 mouse CDK5R2 8941 Q13319 CDK5R2 human S173 18007784 APPVPGGsPRRVIVQ CDK5_activator X -Cdk5 CDK5 P49615 mouse GJA1 14609 P23242 Gja1 mouse S279 448853 SsPtAPLsPMsPPGy X -Cdk5 CDK5 P49615 mouse CASK 12361 O70589 Cask mouse S395 1261102 DKINTkSsPQIRNPP L27 X -Cdk5 CDK5 P49615 mouse MST3 223255 Q99KH8 Stk24 mouse S79 33602703 TVLSQCDsPyVTKYY Pkinase X -Cdk5 CDK5 P49615 mouse DAB1 iso2 13131 P97318-2 Dab1 mouse T385 479416 AMFQGPLtPLATVPG X X -Cdk5 CDK5 P49615 mouse p27Kip1 12576 P46414 Cdkn1b mouse S10 447874 NVRVsNGsPsLERMD X -Cdk5 CDK5 P49615 mouse DAB1 iso2 13131 P97318-2 Dab1 mouse S515 479423 IFEEGFEsPSKSEEQ X X -Cdk5 CDK5 P49615 mouse Vimentin 22352 P20152 Vim mouse S56 451514 sRsLysssPGGAyVt Filament_head X X 3877; 7391 -Cdk5 CDK5 P49615 mouse SEPT5 iso2 100044138 XP_001480843 LOC100044138 mouse S17 475075 RLVEQLLsPRTQAQR X -Cdk5 CDK5 P49615 mouse Doublecortin 13193 O88809 Dcx mouse S287 451360 AAAGPKAsPtPQKTS X -Cdk5 CDK5 P49615 mouse Tau 17762 P10637 Mapt mouse S688 449081 GAEIVyKsPVVsGDt X 9632 -Cdk5 CDK5 P49615 mouse PPP1R1A 58200 Q9ERT9 Ppp1r1a mouse S67 447758 LKSTLsMsPRQRKKM DARPP-32 X X -Cdk5 CDK5 P49615 mouse Doublecortin 13193 O88809 Dcx mouse S339 451359 sPIStPtsPGsLRKH X 3453; 14053 -Cdk5 CDK5 P49615 mouse DAB1 iso2 13131 P97318-2 Dab1 mouse T484 479421 PSTNsPPtPAPRQSs X X -Cdk5 CDK5 P49615 mouse CRMP-1 1400 Q14194 CRMP1 human S522 1295503 PAPsAKssPsKHQPP X -Cdk5 CDK5 P49615 mouse coronin 1A 12721 O89053 Coro1a mouse T418 4701031 DsARRRAtPEPsGtP Trimer_CC X X -Cdk5 CDK5 P49615 mouse STAT3 20848 P42227 Stat3 mouse S727 448191 NtIDLPMsPRTLDSL X X 9134; 9136; 34911; 94994; 49081; 58978; 87544; 71958; 50804 -Cdk5 CDK5 P49615 mouse Doublecortin 13193 O88809 Dcx mouse S297 451111 PQKTSAKsPGPMRRs X X 4605 -Cdk5 CDK5 P49615 mouse IP3R1 16438 P11881 Itpr1 mouse S421 450268 VMLKIGTsPLKEDkE MIR X -Cdk5 CDK5 P49615 mouse Doublecortin 13193 O88809 Dcx mouse T289 451362 AGPKAsPtPQKTSAK X -Cdk5 CDK5 P49615 mouse Tau iso8 4137 P10636-8 MAPT human S202 447928 sGyssPGsPGtPGsR X 39357; 30505 -Cdk5 CDK5 P49615 mouse APE1 11792 P28352 Apex1 mouse T232 14645304 NKkNAGFtPQERQGF Exo_endo_phos X -Cdk5 CDK5 P49615 mouse CDK5R1 8851 Q15078 CDK5R1 human S8 471392 MGTVLSLsPSYRKAT X -Cdk5 CDK5 P49615 mouse DAB1 iso2 13131 P97318-2 Dab1 mouse S491 479422 tPAPRQSsPSKSSAS X X -Cdk5 CDK5 P49615 mouse Doublecortin 13193 O88809 Dcx mouse S332 451363 StPKsKQsPIStPts X -Cdk5 CDK5 P49615 mouse CACNA1C 12288 Q01815 Cacna1c mouse S783 457631 KKLARTAsPEKKQEV X X -Cdk5 CDK5 P49615 mouse DAB1 iso2 13131 P97318-2 Dab1 mouse T476 479419 LtPVTSTtPSTNsPP X X -Cdk5 CDK5 P49615 mouse FAK 14083 P34152 Ptk2 mouse S732 450196 SSEGFYPsPQHMVQT X X -Cdk5 CDK5 P49615 mouse NMDAR2B 14812 Q01097 Grin2b mouse S1116 3984496 yRRRPPRsPDHKRYF NMDAR2_C X X -Cdk5 CDK5 P49615 mouse RAB3IL1 171452 Q99NH3 Rab3il1 rat S180 467059 ELHPQLLsPTKAGPR X -Cdk5 CDK5 P49615 mouse RASGRF1 19417 P27671 Rasgrf1 mouse S737 469604 PLAIGtSsPsRRRKL RasGEF_N X -Cdk5 CDK5 P49615 mouse Huntingtin 15194 P42859 Htt mouse S1179 465620 EQASTPMsPKKVGEA X -Cdk5 CDK5 P49615 mouse PRDX2 21672 Q61171 Prdx2 mouse T89 487517 THLAWINtPRkEGGL AhpC-TSA X X -Cdk5 CDK5 P49615 mouse DAB1 iso2 13131 P97318-2 Dab1 mouse S550 479424 EPSGDNIsPQDGS__ X X -Cdk5 CDK5 P49615 mouse SynGAP 240057 F6SEU4 Syngap1 mouse T790 33636249 MARLPsPtKEkPPPP DUF3498 X -Cdk5 CDK5 P49615 mouse Doublecortin 13193 O88809 Dcx mouse T326 451361 TSSsQLStPKsKQsP X -Cdk5 CDK5 P49615 mouse STMN1 16765 P54227 Stmn1 mouse S38 448556 sVPdFPLsPPKKKDL Stathmin X 3426; 4191 -Cdk5 CDK5 P49615 mouse MEK1 26395 P31938 Map2k1 mouse T286 448286 VEGDAAEtPPRPRtP Pkinase X X 9127 -Cdk5 CDK5 P49615 mouse DAB1 iso2 13131 P97318-2 Dab1 mouse S400 479417 TNDSARSsPQSDKPR X X -Cdk5 CDK5 P49615 mouse DAB1 13131 P97318 Dab1 mouse S524 479422 TPAPRQSsPSKSSAS X -Cdk5 CDK5 P49615 mouse SNTB2 20650 Q61235 Sntb2 mouse S75 471147 NRGLGPPsPPAPPRG X -Cdk5 CDK5 P49615 mouse Bcl-2 12043 P10417 Bcl2 mouse S70 448395 RDMAARtsPLRPLVA X X -Cdk5 CDK5 P49615 mouse Tau 17762 P10637 Mapt mouse T497 447933 ssPGsPGtPGsRsRt X 25377; 43964; 53001; 49561; 20060; 33032; 30505; 20739; 98160 -Cdk5 CDK5 P49615 mouse Tau iso8 4137 P10636-8 MAPT human T181 447932 ktPPAPktPPssGEP X 12885; 66224; 62672 -Cdk5 CDK5 P49615 mouse nestin 18008 Q6P5H2 Nes mouse T1554 449819 GETLPDStPLGLYLK X -Cdk5 CDK5 P49615 mouse DARPP-32 19049 Q60829 Ppp1r1b mouse T75 448048 RPNPCAYtPPSLKAV DARPP-32 X 2301 -Cdk5 CDK5 P49615 mouse MEKK1 26401 P53349 Map3k1 mouse T280 3951974 PFQSGRItPPRRAPs X -Cdk5 CDK5 P49615 mouse Tau 17762 P10637 Mapt mouse S494 447928 sGyssPGsPGtPGsR X 39357; 30505 -Cdk5 CDK5 P49615 mouse TrkB 25054 Q63604 Ntrk2 rat S478 478364 SNDDDSAsPLHHISN X -Cdk5 CDK5 P49615 mouse PAK1 29431 P35465 Pak1 rat T211 448176 VIEPLPVtPTRDVAT X -Cdk5 CDK5 P49615 mouse CACNA1B 257648 Q02294 Cacna1b rat S2016 25792205 TQPAPNAsPMKRSIS X -Cdk5 CDK5 P49615 mouse CDK16 18555 Q04735 Cdk16 mouse S95 453454 tssDEVQsPVRVRMR X -Cdk5 CDK5 P49615 mouse Huntingtin 15194 P42859 Htt mouse S1159 465621 LTNPPSLsPIRRKGK X -Cdk5 CDK5 P49615 mouse CDK5R2 8941 Q13319 CDK5R2 human S8 15499459 MGTVLSLsPASSAKG X -Cdk5 CDK5 P49615 mouse Tau 17762 P10637 Mapt mouse S491 447927 GERsGyssPGsPGtP X 29957 -Cdk5 CDK5 P49615 mouse PPP1R1A 58977 P19103 Ppp1r1a rat S6 478275 __MEPDNsPRKIQFT DARPP-32 X -Cdk5 CDK5 P49615 mouse axin 1 12005 O35625 Axin1 mouse T480 451091 HVQRVMRtPGCQsPG Axin_b-cat_bind X -Cdk5 CDK5 P49615 mouse Doublecortin 13193 O88809 Dcx mouse S28 451358 SRMNGLPsPTHSAHC X -Cdk5 CDK5 P49615 mouse TrkB 18212 P15209 Ntrk2 mouse S478 478364 SNDDDsAsPLHHISN X X -Cdk5 CDK5 P49615 mouse p27Kip1 12576 P46414 Cdkn1b mouse T187 447875 NAGtVEQtPKKPGLR X X -Cdk5 CDK5 P49615 mouse CDK5R2 8941 Q13319 CDK5R2 human T84 4697544 KKGSKKVtPKPASTG X -Cdk5 CDK5 P49615 mouse VACAMKL 235604 Q3UHL1 Camkv mouse T345 60179300 QSASDAAtPGAAGGA X -Cdk5 CDK5 P49615 mouse TH 21823 P24529 Th mouse S31 448544 KQAEAVtsPRFIGRR TOH_N X 3370; 13041 -Pdpk1 PDK1 Q9Z2A0 mouse RSK2 110651 P18654 Rps6ka3 mouse S369 448064 TAKtPKDsPGIPPsA Pkinase_C X -Pdpk1 PDK1 Q9Z2A0 mouse PKCZ 5590 Q05513 PRKCZ human T410 447510 GPGDtTstFCGtPNy Pkinase X X 9378; 2060 -Pdpk1 PDK1 Q9Z2A0 mouse SPHK2 56848 Q9NRA0 SPHK2 human S421 486447 sPLHRsVsDLPLPLP X -Pdpk1 PDK1 Q9Z2A0 mouse RSK2 110651 P18654 Rps6ka3 mouse T577 450152 AENGLLMtPCYtANF Pkinase X -Pdpk1 PDK1 Q9Z2A0 mouse PDK1 18607 Q9Z2A0 Pdpk1 mouse S399 448582 SSSSSSHsLSTVETS X -Pdpk1 PDK1 Q9Z2A0 mouse RSK2 110651 P18654 Rps6ka3 mouse S227 448063 DHEKKAysFCGtVEy Pkinase X 3556 -Pdpk1 PDK1 Q9Z2A0 mouse PKACA 18747 P05132 Prkaca mouse T198 448459 RVKGRtWtLCGtPEY Pkinase X 4781; 5661 -Pdpk1 PDK1 Q9Z2A0 mouse PDK1 18607 Q9Z2A0 Pdpk1 mouse S244 447693 SKQARANsFVGtAQy Pkinase X X 3061; 3438 -Pdpk1 PDK1 Q9Z2A0 mouse PDK1 18607 Q9Z2A0 Pdpk1 mouse T516 450132 PEAKNFKtFFVHTPN PH_3 X -Pdpk1 PDK1 Q9Z2A0 mouse SPHK2 56848 Q9NRA0 SPHK2 human S419 486446 AHsPLHRsVsDLPLP X -Pdpk1 PDK1 Q9Z2A0 mouse RSK2 110651 P18654 Rps6ka3 mouse S386 448065 HQLFRGFsFVAITSD Pkinase_C X 9341; 9335; 13575; 11989; 12032; 75266; 93317; 13397; 13588 -Pdpk1 PDK1 Q9Z2A0 mouse Akt1 11651 P31750 Akt1 mouse T308 447856 KDGAtMKtFCGtPEy Pkinase X X 5106; 2965; 9275; 4056; 5056; 13842; 13038; 43506; 48646; 86758; 80722; 77440; 80556 -Prkcg PKCG P63318 mouse CRMP-2 12934 O08553 Dpysl2 mouse T555 448084 DNIPRRttQRIVAPP X -Prkcg PKCG P63318 mouse RKIP 29542 P31044 Pebp1 rat S153 448755 RGkFkVEsFRKKYHL PBP X -Prkcg PKCG P63318 mouse CAMK2B 12323 P28652 Camk2b mouse S315 451707 MLAtRNFsVGRQTtA X X -Prkcg PKCG P63318 mouse SYN1 20964 O88935 Syn1 mouse S605 450236 AGPtRQAsQAGPGPr X 88246 -Prkcg PKCG P63318 mouse SYN1 20964 O88935 Syn1 mouse S9 448378 NYLRRRLsDsNFMAN Synapsin_N X 2311; 67605 -STK24 MST3 Q9Y6E0 human AMPKA1 5562 Q13131 PRKAA1 human T183 448786 sDGEFLRtsCGsPNy Pkinase X 2535; 2531; 4188; 5256; 50081; 74281 -STK24 MST3 Q9Y6E0 human KEPI 81706 Q8TAE6 PPP1R14C human T73 10296602 RHQQGKVtVkYDRKE PP1_inhibitor X -STK24 MST3 Q9Y6E0 human TAO1 57551 Q7L7X3 TAOK1 human T440 23150854 RNREHFAtIRtAsLV X -STK24 MST3 Q9Y6E0 human QIK 23235 Q9H0K1 SIK2 human T175 456035 kSGELLAtWCGSPPY Pkinase X -STK24 MST3 Q9Y6E0 human RAB8A 4218 P61006 RAB8A human T72 4709152 AGQERFRtITTAyyR Ras X -STK24 MST3 Q9Y6E0 human MST3 8428 Q9Y6E0 STK24 human T190 468211 DtQIkRNtFVGtPFW Pkinase X X -STK24 MST3 Q9Y6E0 human SIK 150094 P57059 SIK1 human T182 456034 kSGEPLStWCGSPPY Pkinase X -STK24 MST3 Q9Y6E0 human TAO1 216965 Q5F2E8 Taok1 mouse T440 23150854 RNREHFAtIRTAsLV X -STK24 MST3 Q9Y6E0 human QSK 23387 Q9Y2K2 SIK3 human T221 456036 TPGQLLKtWCGSPPY Pkinase X X -STK24 MST3 Q9Y6E0 human TAO2 381921 Q6ZQ29 Taok2 mouse T475 23150863 RNRDHFAtIRTAsLV X -STK24 MST3 Q9Y6E0 human NDR2 23012 Q9Y2H1 STK38L human T442 451133 DWVFLNytyKRFEGL Pkinase_C X X -STK24 MST3 Q9Y6E0 human AMPKA2 5563 P54646 PRKAA2 human T172 448026 sDGEFLRtsCGsPNy Pkinase X X 2535; 2531; 5256; 50081; 74281 -STK24 MST3 Q9Y6E0 human Elf-2 1998 Q15723 ELF2 human S107 4779292 EALLHMEsPTCLRDS Elf-1_N X -Speg SPEG Q62407 mouse RYR2 20191 E9Q401 Ryr2 mouse S2367 4777888 GPsPTSGssKTLDIE X -DYRK2 DYRK2 Q92630 human GLI2 14633 Q0VGT2 Gli2 mouse S385 3339001 AEGLRPAsPLGLTQE X -DYRK2 DYRK2 Q92630 human SIAH2 6478 O43255 SIAH2 human S68 5393502 GGGAGPVsPQHHELT X -DYRK2 DYRK2 Q92630 human CARHSP1 23589 Q9Y2V2 CARHSP1 human S41 455702 LRGNVVPsPLPtRRt X -DYRK2 DYRK2 Q92630 human Doublecortin iso2 1641 O43602-2 DCX human S306 454122 GPMRRSKsPADSANG X -DYRK2 DYRK2 Q92630 human CDC25A 993 P30304 CDC25A human S283 58934700 PErsQEEsPPGSTKr M-inducer_phosp X X -DYRK2 DYRK2 Q92630 human SIAH2 6478 O43255 SIAH2 human T119 26371004 PTCRGALtPSIRNLA X -DYRK2 DYRK2 Q92630 human KATNA1 11104 O75449 KATNA1 human S42 26401200 QMNKYLYsVkDTYLQ X -DYRK2 DYRK2 Q92630 human p53 7157 P04637 TP53 human S46 447536 AMDDLMLsPDDIEQW TAD2 X X 2521 -DYRK2 DYRK2 Q92630 human CDC25A 993 P30304 CDC25A human S321 472278 QSLSLAssPKGTIEN M-inducer_phosp X X -DYRK2 DYRK2 Q92630 human CDC25A 993 P30304 CDC25A human S107 31086927 NPMRRIHsLPQkLLG M-inducer_phosp X X -DYRK2 DYRK2 Q92630 human DYRK2 iso2 8445 Q92630-2 DYRK2 human S483 1874397810 SVKRITEstGAItsI X -DYRK2 DYRK2 Q92630 human CDC25A 993 P30304 CDC25A human S18 449976 RRLLFACsPPPASQP X X -DYRK2 DYRK2 Q92630 human eIF2B-epsilon 192234 Q64350 Eif2b5 rat S539 449906 ELDsRAGsPQLDDIR X -DYRK2 DYRK2 Q92630 human KATNA1 11104 O75449 KATNA1 human S109 23117380 VPVERRPsPGPRKRQ X -DYRK2 DYRK2 Q92630 human DYRK2 iso2 8445 Q92630-2 DYRK2 human T484 1874397812 VKRITEstGAItsIS X -DYRK2 DYRK2 Q92630 human DYRK2 iso2 8445 Q92630-2 DYRK2 human T32 1874397806 SNKRTVLttQPNGLT X -DYRK2 DYRK2 Q92630 human KATNA1 11104 O75449 KATNA1 human T133 26401201 HGNRPSTtVRVHRSS X -DYRK2 DYRK2 Q92630 human RPT3 5704 P43686 PSMC4 human T25 3190483 LSVsRPQtGLsFLGP X X -DYRK2 DYRK2 Q92630 human DYRK2 iso2 8445 Q92630-2 DYRK2 human T488 1874397814 TEstGAItsISKLPP X -DYRK2 DYRK2 Q92630 human DYRK2 iso2 8445 Q92630-2 DYRK2 human T82 1874397808 KVKATPMtPEQAMKQ X -DYRK2 DYRK2 Q92630 human CRMP-1 1400 Q14194 CRMP1 human S522 1295503 PAPsAKssPsKHQPP X -DYRK2 DYRK2 Q92630 human 4E-BP1 1978 Q13541 EIF4EBP1 human S65 447527 FLMECrNsPVtktPP eIF_4EBP X 9451; 9456; 13443 -DYRK2 DYRK2 Q92630 human Snail1 6615 O95863 SNAI1 human S104 455881 GkGsQPPsPPsPAPs X -DYRK2 DYRK2 Q92630 human DYRK2 iso2 8445 Q92630-2 DYRK2 human Y309 454666 EHQRVYTyIQSRFYR Pkinase X -DYRK2 DYRK2 Q92630 human H3F3A 3020 P84243 H3-3A human T45 18545304 PHryrPGtVALrEIR Histone X -DYRK2 DYRK2 Q92630 human CDC25A 993 P30304 CDC25A human S88 458298 DsGFCLDsPGPLDSK M-inducer_phosp X -DYRK2 DYRK2 Q92630 human HSF1 3297 Q00613 HSF1 human S363 455486 DtEGRPPsPPPtstP Vert_HS_TF X -DYRK2 DYRK2 Q92630 human Notch 1 4851 P46531 NOTCH1 human T2511 483083 VPEHPFLtPsPEsPD X X -DYRK2 DYRK2 Q92630 human SIAH2 6478 O43255 SIAH2 human T26 5393503 PPPQPQHtPsPAAPP X -DYRK2 DYRK2 Q92630 human CARHSP1 23589 Q9Y2V2 CARHSP1 human S30 467608 tPRsRERsPsPLRGN X -DYRK2 DYRK2 Q92630 human CDC25A 993 P30304 CDC25A human S320 1874397804 HQSLSLAssPKGTIE M-inducer_phosp X X -DYRK2 DYRK2 Q92630 human CARHSP1 23589 Q9Y2V2 CARHSP1 human S32 467609 RsRERsPsPLRGNVV X -DYRK2 DYRK2 Q92630 human HSF1 3297 Q00613 HSF1 human S307 449046 EPPsPPQsPRVEEAs Vert_HS_TF X -DYRK2 DYRK2 Q92630 human HSF1 3297 Q00613 HSF1 human S320 3849409 AsPGRPssVDtLLsP Vert_HS_TF X X -DYRK2 DYRK2 Q92630 human GYS1 100008660 P13834 GYS1 rabbit S641 448237 YRYPRPAsVPPsPSL Glycogen_syn X -DYRK2 DYRK2 Q92630 human CRMP-4 1809 Q14195 DPYSL3 human S522 458800 PAGsArGsPtRPNPP X -DYRK2 DYRK2 Q92630 human CRMP-2 1808 Q16555 DPYSL2 human S522 448082 PAssAktsPAkQQAP X -DYRK2 DYRK2 Q92630 human GLI2 14633 Q0VGT2 Gli2 mouse S1011 3339000 NLtRNAYsPRPPSIN X -DYRK2 DYRK2 Q92630 human Tau iso8 4137 P10636-8 MAPT human T212 447934 tPGsRsRtPsLPtPP X -DYRK2 DYRK2 Q92630 human DYRK2 iso2 8445 Q92630-2 DYRK2 human S497 1874397818 ISKLPPPsssAsKLR X -DYRK2 DYRK2 Q92630 human DYRK2 iso2 8445 Q92630-2 DYRK2 human T33 11489910 NKRTVLttQPNGLTT X -DYRK2 DYRK2 Q92630 human SIAH2 6478 O43255 SIAH2 human S16 26371003 PsANkPCsKQPPPQP X -DYRK2 DYRK2 Q92630 human HSF1 3297 Q00613 HSF1 human S326 455484 ssVDtLLsPTALIDs Vert_HS_TF X X -DYRK2 DYRK2 Q92630 human 4E-BP1 1978 Q13541 EIF4EBP1 human S101 449033 sQSHLRNsPEDKRAG eIF_4EBP X -DYRK2 DYRK2 Q92630 human CDC25A 993 P30304 CDC25A human S156 1874397800 KkPVRPVsRGCLHSH M-inducer_phosp X X -DYRK2 DYRK2 Q92630 human CDC25A 993 P30304 CDC25A human S185 1874397802 sAPARMLsSNERDSS M-inducer_phosp X X -DYRK2 DYRK2 Q92630 human TBK1 29110 Q9UHD2 TBK1 human S527 50318715 QDIDSRLsPGGSLAD TBK1_CCD1 X -DYRK2 DYRK2 Q92630 human DYRK2 iso2 8445 Q92630-2 DYRK2 human S489 1874397816 EstGAItsISKLPPP X -DYRK2 DYRK2 Q92630 human SIAH2 6478 O43255 SIAH2 human S28 471339 PQPQHtPsPAAPPAA X X -DYRK2 DYRK2 Q92630 human HSF1 3297 Q00613 HSF1 human T323 4169776 GRPssVDtLLsPTAL Vert_HS_TF X -DYRK2 DYRK2 Q92630 human NDEL1 83431 Q9ERR1 Ndel1 mouse S336 1869686801 LGSsRPSsAPGMLPL X -BUB1 BUB1 O43683 human BUB3 9184 O43684 BUB3 human S19 15180600 PPEDGISsVkFSPNT WD40 X -BUB1 BUB1 O43683 human CDC20 991 Q12834 CDC20 human S72 454659 SkVQttPskPGGDRy X -BUB1 BUB1 O43683 human BUB1 699 O43683 BUB1 human T589 3175277 WGIRCNktLAPsPks X -BUB1 BUB1 O43683 human BUB1 699 O43683 BUB1 human S563 479887 RsVSRLPsKPKEEVP X -BUB1 BUB1 O43683 human CDC20 991 Q12834 CDC20 human S41 454658 EAAGPAPsPMRAANR X -BUB1 BUB1 O43683 human CDC20 991 Q12834 CDC20 human S161 454663 QkAtPGssRKtCRYI X -BUB1 BUB1 O43683 human BUB1 699 O43683 BUB1 human S510 31860534 QFQkNVRssGAWGVN X -BUB1 BUB1 O43683 human BUB1 699 O43683 BUB1 human S667 20722783 ksPkQALssHMysAS X -BUB1 BUB1 O43683 human BUB1 699 O43683 BUB1 human S969 20722066 FTAKCETsGFQCVEM Pkinase X -BUB1 BUB1 O43683 human BUB1 699 O43683 BUB1 human T960 50318708 MKLFPkGtIFTAKCE Pkinase X -BUB1 BUB1 O43683 human BUB1 699 O43683 BUB1 human T148 50318709 RLFQTRLtETHLPAQ X -BUB1 BUB1 O43683 human BUB1 699 O43683 BUB1 human T552 50318703 NKPTGARtFGERsVS X -BUB1 BUB1 O43683 human BUB1 699 O43683 BUB1 human T213 50318707 NMERRVItISkSEys X -BUB1 BUB1 O43683 human CDC20 991 Q12834 CDC20 human S153 454661 NRLkVLysQkAtPGs X -BUB1 BUB1 O43683 human STAT3 6774 P40763 STAT3 human S727 448191 NtIDLPMsPrTLDSL X X 9134; 9136; 34911; 94994; 49081; 58978; 87544; 71958; 50804 -BUB1 BUB1 O43683 human CDC20 991 Q12834 CDC20 human S92 454660 AAQMEVAsFLLSkEN X -BUB1 BUB1 O43683 human BUB1 699 O43683 BUB1 human S419 50318705 THEFkPQsGAEIKEG X -BUB1 BUB1 O43683 human BUB1 699 O43683 BUB1 human S679 20722063 sASLLRLsQPAAGGV X -BUB1 BUB1 O43683 human BUB1 699 O43683 BUB1 human T173 50318701 QVLNQMItSksNPGN X -BUB1 BUB1 O43683 human CDC20 991 Q12834 CDC20 human T157 454662 VLysQkAtPGssRKt X -BUB1 BUB1 O43683 human BUB1 699 O43683 BUB1 human S454 50318710 GMVQAtPskVQPsPt X -BUB1 BUB1 O43683 human H2A.1 8329 P0C0S8 H2AC17 human T120 482914 AVLLPkktEsHHkAk Histone_H2A_C X X -BUB1 BUB1 O43683 human BUB1 699 O43683 BUB1 human S511 12667749 FQkNVRssGAWGVNK X -BUB1 BUB1 O43683 human BUB1 699 O43683 BUB1 human S618 50318702 FHkLPVEsVHILEDk X -BUB1 BUB1 O43683 human BUB1 699 O43683 BUB1 human S176 20722779 NQMItSksNPGNNMA X -BUB1 BUB1 O43683 human BUB1 699 O43683 BUB1 human S752 50318706 KLIFKLLsGLskPVS X -BUB1 BUB1 O43683 human BUB1 699 O43683 BUB1 human S525 31084641 KIISSLSsAFHVFED X -BUB1 BUB1 O43683 human BUB1 699 O43683 BUB1 human S198 50318711 SELsGVIsSACDkES X -PRKCE PKCE Q02156 human UGT1A7 54577 Q9HAW7 UGT1A7 human S432 455595 KAVINDKsYkENIMR UDPGT X -PRKCE PKCE Q02156 human Tau iso8 4137 P10636-8 MAPT human S352 487459 DFKDrVQskIGsLDN Tubulin-binding X -PRKCE PKCE Q02156 human CENTA1 11033 O75689 ADAP1 human T276 11380901 GFRkRWFtMDDRRLM PH X -PRKCE PKCE Q02156 human SLC24A2 84550 O54701 Slc24a2 rat S504 471068 PDVRKPAsKKFFPIT X -PRKCE PKCE Q02156 human KEAP1 9817 Q14145 KEAP1 human S602 29606703 TRMTsGRsGVGVAVT X X -PRKCE PKCE Q02156 human TACE 6868 P78536 ADAM17 human T735 449804 kPFPAPQtPGRLQPA X -PRKCE PKCE Q02156 human GIRK4 16521 P48545 Kcnj5 mouse S418 1884003506 VSQATRGsM______ X -PRKCE PKCE Q02156 human K8 16691 P11679 Krt8 mouse S9 484004 sIRVTQKsYkMstsG Keratin_2_head X -PRKCE PKCE Q02156 human TNNI3 511094 P08057 TNNI3 cow S44 450690 AKKKSKIsAsRKLQL X -PRKCE PKCE Q02156 human PKM 5315 P14618 PKM human Y105 450528 FAsDPILyRPVAVAL PK X 3827 -PRKCE PKCE Q02156 human G-alpha i2 2771 P04899 GNAI2 human S144 451341 VQACFGRsREyQLND G-alpha X -PRKCE PKCE Q02156 human CACNA1C 100101555 P15381 CACB rabbit S1928 455278 ASLGRRAsFHLECLK CAC1F_C X -PRKCE PKCE Q02156 human CACNA1B 257648 Q02294 Cacna1b rat S2108 465549 RKQERGRsQERRQPS X -PRKCE PKCE Q02156 human NANOG 79923 Q9H9S0 NANOG human T200 28070707 LPMWSNQtWNNSTWS X X -PRKCE PKCE Q02156 human TNNT2 286816 P13789 TNNT2 cow S195 451755 KAQtERKsGKRQtER Troponin X -PRKCE PKCE Q02156 human GJA1 24392 P08050 Gja1 rat S364 450183 AIVDQRPssRAssRA X -PRKCE PKCE Q02156 human TNNT2 286816 P13789 TNNT2 cow T191 449038 GYIQKAQtERKsGKR Troponin X -PRKCE PKCE Q02156 human NANOG 79923 Q9H9S0 NANOG human S135 17399913 LSNILNLsYKQVKTW Homeodomain X -PRKCE PKCE Q02156 human PKCE 5581 Q02156 PRKCE human S316 2085100 tPDKITNsGQRRkKL X -PRKCE PKCE Q02156 human ZO1 21872 P39447 Tjp1 mouse S168 470469 AsRERsLsPRsDRRs X -PRKCE PKCE Q02156 human NANOG 79923 Q9H9S0 NANOG human S79 28070708 PKGKQPtsAEKSVAK X -PRKCE PKCE Q02156 human G-alpha i2 2771 P04899 GNAI2 human S302 12575206 NkYDEAAsyIQSkFE G-alpha X -PRKCE PKCE Q02156 human PPP1R14A 94274 Q96A00 PPP1R14A human T38 449098 QkRHARVtVkYDRRE PP1_inhibitor X -PRKCE PKCE Q02156 human MOR-1 18390 P42866 Oprm1 mouse S363 447783 STIEQQNsARIRQNt X -PRKCE PKCE Q02156 human SCN10A Q62968 Scn10a rat S1452 25126701 NAMKKLGsKKPQKPI X -PRKCE PKCE Q02156 human NSF P18708 NSF hamster S460 15794301 MNRHIKAstKVEVDM AAA_lid_3 X -PRKCE PKCE Q02156 human MCU 90550 Q8NE86 MCU human S92 27259017 VISVRLPsRRERCQF X -PRKCE PKCE Q02156 human EGFR 1956 P00533 EGFR human T678 448053 RHIVRKRtLRRLLQE X 14343 -PRKCE PKCE Q02156 human AID 11628 Q9WVE0 Aicda mouse S3 20660600 _____MDsLLMKQKK X -PRKCE PKCE Q02156 human CACNA1C 100101555 P15381 CACB rabbit S533 453091 RIsKSKFsRYWRRWN X -PRKCE PKCE Q02156 human SLC6A2 6530 P23975 SLC6A2 human S259 465614 LWKGVKtsGKVVWIT SNF X -PRKCE PKCE Q02156 human MIIP 60672 Q5JXC2 MIIP human S303 4170074 YHIHRRKsFDASDTL MIIP X X -PRKCE PKCE Q02156 human PLM 476487 P56513 FXYD1 dog S83 451424 EEGTFRSsIRRLstR X -PRKCE PKCE Q02156 human KEAP1 9817 Q14145 KEAP1 human S599 29606702 SEVTRMTsGRsGVGV X -PRKCE PKCE Q02156 human GJA1 24392 P08050 Gja1 rat S372 465460 sRAssRAssRPRPDD X -PRKCE PKCE Q02156 human CENTA1 11033 O75689 ADAP1 human S87 11380900 AARARFEsKVPSFYY ArfGap X -PRKCE PKCE Q02156 human IRS1 16367 P35569 Irs1 mouse S318 451399 MVGGKPGsFRVRASs X 5610 -PRKCE PKCE Q02156 human Tau iso8 4137 P10636-8 MAPT human S324 449328 kVtskCGsLGNIHHk Tubulin-binding X -PRKCE PKCE Q02156 human AurB 9212 Q96GD4 AURKB human S227 4271812 GWSVHAPsLRRktMC Pkinase X X -PRKCE PKCE Q02156 human PLM 476487 P56513 FXYD1 dog S88 451425 RSsIRRLstRRR___ X -PRKCE PKCE Q02156 human PKCE 5581 Q02156 PRKCE human S234 479975 EtPDQVGsQRFSVNM X -PRKCE PKCE Q02156 human TNNT2 24837 P50753 Tnnt2 rat S209 451755 kAQtERKsGKRQtER Troponin X -PRKCE PKCE Q02156 human SLC24A2 84550 O54701 Slc24a2 rat T166 471069 VPSLTVItEKLGISD Na_Ca_ex X -PRKCE PKCE Q02156 human CHAT iso3 1103 P28329-3 CHAT human S440 449057 VPTYESAsIRRFQEG Carn_acyltransf X -PRKCE PKCE Q02156 human GJA1 24392 P08050 Gja1 rat S365 459207 IVDQRPssRAssRAs X -PRKCE PKCE Q02156 human ITGB1 3688 P05556 ITGB1 human T789 447709 IyksAVttVVNPkyE Integrin_b_cyt X -PRKCE PKCE Q02156 human STAT3 6774 P40763 STAT3 human S727 448191 NtIDLPMsPrTLDSL X 9134; 9136; 34911; 94994; 49081; 58978; 87544; 71958; 50804 -PRKCE PKCE Q02156 human TNNI3 511094 P08057 TNNI3 cow S46 450691 KKSKIsAsRKLQLKT X -PRKCE PKCE Q02156 human TNNI3 7137 P19429 TNNI3 human S44 450691 KKskIsAsRKLQLKt X -PRKCE PKCE Q02156 human NSF P18708 NSF hamster T461 15794300 NRHIKAstKVEVDME AAA_lid_3 X -PRKCE PKCE Q02156 human P311 9315 Q16612 NREP human S59 457551 LGSSELRsPRISYLH Alveol-reg_P311 X -PRKCE PKCE Q02156 human ZO2 403854 Q95168 TJP2 dog S369 9730701 QLVVLRDsKQTLINI X X -PRKCE PKCE Q02156 human PKCE 5581 Q02156 PRKCE human K534 1870790710 GVIYRDLkLDNILLD Pkinase X -PRKCE PKCE Q02156 human TNNT2 286816 P13789 TNNT2 cow T200 451556 RKsGKRQtEREKKKK Troponin X -PRKCE PKCE Q02156 human Tau iso8 4137 P10636-8 MAPT human S293 449327 NVQskCGsKDNIkHV Tubulin-binding X -PRKCE PKCE Q02156 human BAD 572 Q92934 BAD human S99 447862 PFrGrsRsAPPNLWA Bcl-2_BAD X 9295; 5286; 4366 -PRKCE PKCE Q02156 human TNNI3 511094 P08057 TNNI3 cow S79 451839 GEKGRALsTRCQPLE Troponin X -PRKCE PKCE Q02156 human ALDH2 217 P05091 ALDH2 human T429 62906102 MQILkFKtIEEVVGR Aldedh X -PRKCE PKCE Q02156 human PRKD2 25865 Q9BZL6 PRKD2 human S706 449864 ARIIGEksFRRsVVG Pkinase X -PRKCE PKCE Q02156 human PRKD2 25865 Q9BZL6 PRKD2 human S710 449865 GEksFRRsVVGtPAy Pkinase X -PRKCE PKCE Q02156 human occludin 100506658 Q16625 OCLN human T404 471472 HyEtDyttGGEsCDE X X -PRKCE PKCE Q02156 human KCNK3 3777 O14649 KCNK3 human T383 2840502 TGLHSLStFRGLMKR X X -PRKCE PKCE Q02156 human ephexin-5 442801 Q5FWH6 Arhgef15 mouse S107 17546056 PSPVSRRsIsPEPAP X X -PRKCE PKCE Q02156 human FGFR1 2260 P11362 FGFR1 human S779 27930809 PLDQysPsFPDTRSS X X -PRKCE PKCE Q02156 human TRPV1 7442 Q8NER1 TRPV1 human S801 450017 VPLLREAsARDRQsA X -PRKCE PKCE Q02156 human TICAM2 353376 Q86XR7 TICAM2 human S16 465617 NSCPLsLsWGKRHsV X X -PRKCE PKCE Q02156 human NANOG 79923 Q9H9S0 NANOG human T78 28070706 sPKGKQPtsAEKSVA X -PRKCE PKCE Q02156 human BAD 572 Q92934 BAD human S75 447860 EIRsRHssyPAGtED Bcl-2_BAD X X 9291; 5284; 9296; 5193; 11865; 94223 -PRKCE PKCE Q02156 human CACNA1B 257648 Q02294 Cacna1b rat S1757 465548 FEMLKHMsPPLGLGK GPHH X -PRKCE PKCE Q02156 human Tau iso8 4137 P10636-8 MAPT human S258 487453 PDLkNVKskIGstEN Tubulin-binding X -PRKCE PKCE Q02156 human CREB 1385 P16220 CREB1 human S119 448228 EILsRRPsyRkILND pKID X 9187; 9196; 9198; 4095; 14228; 14001; 39561; 80120; 44864; 54960; 95995 -PRKCE PKCE Q02156 human KIR3DL1 3811 P43629 KIR3DL1 human S415 990302 QRKITRPsQRPKtPP X -PRKCE PKCE Q02156 human XIAP 331 P98170 XIAP human S87 450336 VGRHRKVsPNCRFIN BIR X -PRKCE PKCE Q02156 human CACNA1B 257648 Q02294 Cacna1b rat S2132 465550 YsCDRFGsREPPQPK X -PRKCE PKCE Q02156 human P70S6KB 6199 Q9UBS0 RPS6KB2 human S473 450071 PPSGTKKsKRGRGRP X X -PRKCE PKCE Q02156 human K18 3875 P05783 KRT18 human S53 447734 IsVsrstsFrGGMGs X -PRKCE PKCE Q02156 human G-alpha i2 2771 P04899 GNAI2 human S44 12575205 LLLGAGEsGkSTIVk G-alpha X -PRKCE PKCE Q02156 human K8 16691 P11679 Krt8 mouse S24 448538 PrAFssRsFtsGPGA Keratin_2_head X -PRKCE PKCE Q02156 human PKCE 5581 Q02156 PRKCE human S729 448789 QEEFKGFsYFGEDLM Pkinase_C X X 9371 -PRKCE PKCE Q02156 human SLC24A2 84550 O54701 Slc24a2 rat T476 471067 SLSWPSNtRKQITFL X -PRKCE PKCE Q02156 human GJA1 24392 P08050 Gja1 rat S368 447813 QRPssRAssRAssRP X 3511; 52559 -PRKCE PKCE Q02156 human BAD 572 Q92934 BAD human S118 447863 GRELRRMsDEFVDsF Bcl-2_BAD X 9297 -PRKCE PKCE Q02156 human TET1 80312 Q8NFU7 TET1 human T1164 1881549500 DRRKkKPtVVSYQEN X X -PRKCE PKCE Q02156 human glutaminase iso3 2744 O94925-3 GLS human S314 937769500 RYVGKEPsGLRFNKL Glutaminase X X -PRKCE PKCE Q02156 human TNNI3 511094 P08057 TNNI3 cow T145 451483 RGKFKRPtLRRVRIS Troponin X -PRKCE PKCE Q02156 human IQGAP1 8826 P46940 IQGAP1 human S1443 454416 DKMKKsksVkEDsNL X X -PRKCE PKCE Q02156 human ALDH2 217 P05091 ALDH2 human T202 62906103 KLGPALAtGNVVVMK Aldedh X -PRKCE PKCE Q02156 human CACNA1C 100101555 P15381 CACB rabbit S528 486358 ARLAHRIsKSKFsRY X -PRKCE PKCE Q02156 human PRKD1 5587 Q15139 PRKD1 human S738 448589 ARIIGEksFRRsVVG Pkinase X 2054 -PRKCE PKCE Q02156 human coronin 1B 57175 Q9BR76 CORO1B human S2 456131 ______MsFRKVVRQ X -PRKCE PKCE Q02156 human GJA1 24392 P08050 Gja1 rat S369 459208 RPssRAssRAssRPR X -PRKCE PKCE Q02156 human RAB11A 8766 P62491 RAB11A human S177 22826101 TEIYRIVsQkQMSDR X -PRKCE PKCE Q02156 human RAB5A 5868 P20339 RAB5A human T7 33622402 _MAsrGAtRPNGPNT X -PRKCE PKCE Q02156 human NANOG 79923 Q9H9S0 NANOG human T280 28070709 GLNVIQQtTRYFStP X X -PRKCE PKCE Q02156 human MYBPC3 17868 O70468 Mybpc3 mouse S302 471081 sLLKKRDsFRRDskL X X -PRKCE PKCE Q02156 human ITGB1 3688 P05556 ITGB1 human T788 448600 PIyksAVttVVNPky Integrin_b_cyt X -PRKCE PKCE Q02156 human KCNK3 E2RAI2 KCNK3 dog T373 2840502 TGLHSLStFRGLMKR X -PRKCE PKCE Q02156 human CHAT iso3 1103 P28329-3 CHAT human S476 454037 HKAAVPAsEKLLLLK Carn_acyltransf X -PRKCE PKCE Q02156 human CACNA1B 257648 Q02294 Cacna1b rat S425 465547 KRAAtKKsRNDLIHA X -PRKCE PKCE Q02156 human GJA1 2697 P17302 GJA1 human S368 447813 QRPssRAssRAssRP X X 3511; 52559 -PRKCE PKCE Q02156 human ephexin-5 442801 Q5FWH6 Arhgef15 mouse S109 17546059 PVSRRsIsPEPAPCS X X -PRKCE PKCE Q02156 human TNNT2 286816 P13789 TNNT2 cow T281 451557 TRGKAKVtGRWK___ X -PRKCE PKCE Q02156 human CACNA1D 29716 P27732 Cacna1d rat S81 470135 PPPVGSLsQRKRQQY X -PRKCE PKCE Q02156 human K8 16691 P11679 Krt8 mouse S47 484005 RVGsssssFRGSMGT Keratin_2_head X -PRKCE PKCE Q02156 human PRKD2 25865 Q9BZL6 PRKD2 human S876 448800 QGLAERIsVL_____ X -PRKCE PKCE Q02156 human CACNA1B 257648 Q02294 Cacna1b rat T422 465546 AVLKRAAtKKsRNDL X -PRKCE PKCE Q02156 human PLM 476487 P56513 FXYD1 dog T89 455220 SsIRRLstRRR____ X -PRKCE PKCE Q02156 human IKKB 3551 O14920 IKBKB human S177 447492 AkELDQGsLCtsFVG Pkinase X X 2078; 2697; 2694; 14938; 92255; 36516; 36214 -PRKCE PKCE Q02156 human TNNT2 21956 P50752 Tnnt2 mouse S211 451755 QAQtERKsGKRQtER Troponin X -PRKCE PKCE Q02156 human ALDH2 217 P05091 ALDH2 human S296 62906101 KSPNIIMsDADMDWA Aldedh X -PRKCE PKCE Q02156 human GABRG2 29709 Q6PW52 Gabrg2 rat S365 486436 FVSNRKPsKDKDKKK Neur_chan_memb X -PRKCE PKCE Q02156 human occludin 100506658 Q16625 OCLN human T403 471471 DHyEtDyttGGEsCD X X -PRKCE PKCE Q02156 human PKCE 5581 Q02156 PRKCE human S368 2085101 NNIRKALsFDNRGEE X -PRKCE PKCE Q02156 human ATF-2 1386 P15336 ATF2 human T52 23305000 HkHKHEMtLKFGPAR X X -PRKCE PKCE Q02156 human GJA1 24392 P08050 Gja1 rat S373 459209 RAssRAssRPRPDDL X -PRKCE PKCE Q02156 human PRKD1 5587 Q15139 PRKD1 human S742 448590 GEksFRRsVVGtPAy Pkinase X -PRKCE PKCE Q02156 human CTNND1 1500 O60716 CTNND1 human S268 450453 PQVRVGGssVDLHRF X X -PRKCE PKCE Q02156 human Met 4233 P08581 MET human S985 450188 PHLDRLVsARsVsPt X -Csnk2a1 CK2A1 P19139 rat PAR-4 64513 Q62627 Pawr rat S223 476476 GRYKSTIsAPEEEIL ATG16 X X -Csnk2a1 CK2A1 P19139 rat BAD 12015 Q61337 Bad mouse T117 454387 HssyPAGtEEDEGME Bcl-2_BAD X -Csnk2a1 CK2A1 P19139 rat TCF4 6925 P15884 TCF4 human S55 451215 SNVEDRsssGSWGNG X -Csnk2a1 CK2A1 P19139 rat RIC8A 293614 Q80ZG1 Ric8a rat S435 468627 GRPEGQYsEDEDtDT Ric8 X -Csnk2a1 CK2A1 P19139 rat NFAT2 4772 O95644 NFATC1 human S187 465578 RSCNsEAsSYESNYS X -Csnk2a1 CK2A1 P19139 rat SSB 6741 P05455 SSB human S366 449301 GkktKFAsDDEHDEH X -Csnk2a1 CK2A1 P19139 rat DEK 7913 P35659 DEK human S301 465703 QNsSKKEsEsEDssD X -Csnk2a1 CK2A1 P19139 rat PAM 25508 P14925 Pam rat T946 455820 KGFDRVstEGsDQEK X -Csnk2a1 CK2A1 P19139 rat GAP43 29423 P07936 Gap43 rat T88 449599 kEGDGsAttDAAPAt Neuromodulin X -Csnk2a1 CK2A1 P19139 rat NCAM-L1 50687 Q05695 L1cam rat S1183 465573 GEyRsLEsDNEEKAF Bravo_FIGEY X -Csnk2a1 CK2A1 P19139 rat GAP43 29423 P07936 Gap43 rat T95 449601 ttDAAPAtsPKAEEP Neuromodulin X -Csnk2a1 CK2A1 P19139 rat Calmodulin 801 P0DP23 CALM3 human S82 448705 RkMkDtDsEEEIrEA X -Csnk2a1 CK2A1 P19139 rat eIF2B-epsilon 192234 Q64350 Eif2b5 rat S712 449907 LREAEEEssDDD___ W2 X -Csnk2a1 CK2A1 P19139 rat PAR-4 64513 Q62627 Pawr rat S124 28030293 GDEEEPDsAPEKGRS X X -Csnk2a1 CK2A1 P19139 rat p53 22059 P02340 Tp53 mouse S389 447535 VkkVGPDsD______ X 9281 -Csnk2a1 CK2A1 P19139 rat PTMA 786336 P01252 PTMA cow T13 459125 VDtSSEIttKDLKEK Prothymosin X -Csnk2a1 CK2A1 P19139 rat TCF4 6925 P15884 TCF4 human S54 451214 GSNVEDRsssGSWGN X -Csnk2a1 CK2A1 P19139 rat EGR1 1958 P18146 EGR1 human S378 11421601 RICMRNFsRSDHLTT zf-C2H2 X -Csnk2a1 CK2A1 P19139 rat calsequestrin 2 483134 P12637 CASQ2 dog S397 451464 DDDDGNNsDEEsNDD X X -Csnk2a1 CK2A1 P19139 rat GAP43 29423 P07936 Gap43 rat S96 449105 tDAAPAtsPKAEEPS Neuromodulin X -Csnk2a1 CK2A1 P19139 rat YY1 24919 Q8CHJ4 Yy1 rat S117 460025 EVVGGDDsDGLRAED X -Csnk2a1 CK2A1 P19139 rat Calmodulin 801 P0DP23 CALM3 human T80 448704 MARkMkDtDsEEEIr X -Csnk2a1 CK2A1 P19139 rat MAX 60661 P52164 Max rat S11 449308 NDDIEVEsDEEQPRF X -Csnk2a1 CK2A1 P19139 rat GAP43 29423 P07936 Gap43 rat S192 449598 PTETAEssQAEEEkE Neuromodulin X -Csnk2a1 CK2A1 P19139 rat EGR1 1958 P18146 EGR1 human S301 11423702 AFATQSGsQDLKALN X -Csnk2a1 CK2A1 P19139 rat SLK 9748 Q9H2G2 SLK human S347 466943 ssDLsIAssEEDKLs X -Csnk2a1 CK2A1 P19139 rat TNNT3 100009527 P02641 TNNT3 rabbit S2 466430 ______MsDEEVEHV X -Csnk2a1 CK2A1 P19139 rat PTMA 786336 P01252 PTMA cow T14 459126 DtSSEIttKDLKEKK Prothymosin X -Csnk2a1 CK2A1 P19139 rat TUBB3 246118 Q4QRB4 Tubb3 rat S444 451154 YEDDDEEsEAQGPK_ X -Csnk2a1 CK2A1 P19139 rat eIF2-beta 100009285 P41035 EIF2S2 rabbit S67 450072 DSRKKDAsDDLDDLN X -Csnk2a1 CK2A1 P19139 rat HMGA1 3159 P17096 HMGA1 human S102 452254 EEGIsQEssEEEQ__ X -Csnk2a1 CK2A1 P19139 rat SLK 9748 Q9H2G2 SLK human S348 466944 sDLsIAssEEDKLsQ X -Csnk2a1 CK2A1 P19139 rat CDC37 114562 Q63692 Cdc37 rat S13 450034 VWDHIEVsDDEDETH CDC37_N X X 13248 -Csnk2a1 CK2A1 P19139 rat DEK 7913 P35659 DEK human S244 476134 KKNKEEssDDEDKEs X -Csnk2a1 CK2A1 P19139 rat DEK 7913 P35659 DEK human S306 465705 KEsEsEDssDDEPLI X -Csnk2a1 CK2A1 P19139 rat Jun 24516 P17325 Jun rat S63 447686 KNSDLLtsPDVGLLK Jun X 5464; 9261; 2361; 97721; 91952 -Csnk2a1 CK2A1 P19139 rat EGR1 1958 P18146 EGR1 human S196 11423701 PLSCAVPsNDSSPIY DUF3446 X -Csnk2a1 CK2A1 P19139 rat PSMA3 29670 P18422 Psma3 rat S243 451184 AEkyAKEsLKEEDEs X -Csnk2a1 CK2A1 P19139 rat p70S6K 83840 P67999 Rps6kb1 rat S40 450117 DQPEDAGsEDELEEG X -Csnk2a1 CK2A1 P19139 rat ODC 18263 P00860 Odc1 mouse S303 451283 VWKEQPGsDDEDESN Orn_DAP_Arg_deC X -Csnk2a1 CK2A1 P19139 rat DEK 7913 P35659 DEK human S32 465616 MPGPREEsEEEEDED X -Csnk2a1 CK2A1 P19139 rat PTMA 786336 P01252 PTMA cow T8 459124 MSDAAVDtSSEIttK Prothymosin X -Csnk2a1 CK2A1 P19139 rat SP1 24790 Q01714 Sp1 rat T669 452043 SYCGKRFtRsDELQR zf-C2H2 X -Csnk2a1 CK2A1 P19139 rat MAX 60661 P52164 Max rat S2 449307 ______MsDNDDIEV X -Csnk2a1 CK2A1 P19139 rat Calmodulin 24242 P0DP29 Calm3 rat S102 448706 kDGNGyIsAAELRHV EF-hand_7 X -Csnk2a1 CK2A1 P19139 rat EGR1 1958 P18146 EGR1 human S104 11423700 YEHLTAEsFPDISLN X -Csnk2a1 CK2A1 P19139 rat CPT1A 25757 P32198 Cpt1a rat S747 479871 FsSPETDsHRFGKHL Carn_acyltransf X -Csnk2a1 CK2A1 P19139 rat DEK 7913 P35659 DEK human S303 465704 sSKKEsEsEDssDDE X -Csnk2a1 CK2A1 P19139 rat Calmodulin 801 P0DP23 CALM3 human S102 448706 kDGNGyIsAAELrHV EF-hand_7 X -Csnk2a1 CK2A1 P19139 rat p70S6K iso2 83840 P67999-2 Rps6kb1 rat S17 450117 DQPEDAGsEDELEEG X -Csnk2a1 CK2A1 P19139 rat calsequestrin 1 100009095 P07221 CASQ1 rabbit T381 451337 VLEGEINtEDDDDED Calsequestrin X -Csnk2a1 CK2A1 P19139 rat ACC1 60581 P11497 Acaca rat S29 448771 GsVsEDNsEDEIsNL X -Csnk2a1 CK2A1 P19139 rat Calmodulin 24242 P0DP29 Calm3 rat T80 448704 MARKMkDtDsEEEIR X -Csnk2a1 CK2A1 P19139 rat PAR-4 5074 Q96IZ0 PAWR human S231 476476 GRyksttsVsEEDVS X -Csnk2a1 CK2A1 P19139 rat calsequestrin 2 483134 P12637 CASQ2 dog S405 1868253001 DEEsNDDsDDDDE__ X X -Csnk2a1 CK2A1 P19139 rat RIC8A 293614 Q80ZG1 Ric8a rat T440 468628 QYsEDEDtDTEEYRE Ric8 X -Csnk2a1 CK2A1 P19139 rat TAGLN 25123 P31232 Tagln rat T139 18016558 ALGSLAVtKNDGHYR CH X -Csnk2a1 CK2A1 P19139 rat eIF2-beta 100009285 P41035 EIF2S2 rabbit S2 451805 ______MsGDEMIFD X -Csnk2a1 CK2A1 P19139 rat EGR1 1958 P18146 EGR1 human T148 11423703 PAPNSGNtLWPEPLF DUF3446 X -Csnk2a1 CK2A1 P19139 rat STX1A 116470 P32851 Stx1a rat S14 451261 ELRTAKDsDDDDDVt X X -Csnk2a1 CK2A1 P19139 rat calsequestrin 2 483134 P12637 CASQ2 dog S401 451475 GNNsDEEsNDDsDDD X X -Csnk2a1 CK2A1 P19139 rat TCF4 6925 P15884 TCF4 human S56 451216 NVEDRsssGSWGNGG X -Csnk2a1 CK2A1 P19139 rat Calmodulin 24242 P0DP29 Calm3 rat S82 448705 RKMkDtDsEEEIREA X X -Csnk2a1 CK2A1 P19139 rat PSMA3 29670 P18422 Psma3 rat S250 451185 sLKEEDEsDDDNM__ X -Csnk2a1 CK2A1 P19139 rat eIF2B-epsilon 192234 Q64350 Eif2b5 rat S713 449908 REAEEEssDDD____ W2 X -Csnk2a1 CK2A1 P19139 rat HMGA1 3159 P17096 HMGA1 human S103 452255 EGIsQEssEEEQ___ X -Csnk2a1 CK2A1 P19139 rat Jun 24516 P17325 Jun rat S73 447943 VGLLKLAsPELERLI Jun X 9164; 3270; 8752; 12714; 77955 -Csnk2a1 CK2A1 P19139 rat NMDAR2B 24410 Q00960 Grin2b rat S1480 454415 EKLssIEsDV_____ NMDAR2_C X -Csnk2a1 CK2A1 P19139 rat DEK 7913 P35659 DEK human S243 476133 EKKNKEEssDDEDKE X -Csnk2a1 CK2A1 P19139 rat ARC 85383 Q62881 Nol3 rat T149 448618 SEAVQPRtPEEPELE X -Csnk2a1 CK2A1 P19139 rat GAP43 29423 P07936 Gap43 rat T89 449600 EGDGsAttDAAPAts Neuromodulin X -Csnk2a1 CK2A1 P19139 rat Calmodulin 801 P0DP23 CALM3 human T118 469586 tNLGEkLtDEEVDEM EF-hand_7 X -Csnk2a1 CK2A1 P19139 rat GAP43 29423 P07936 Gap43 rat S191 449597 PPTETAEssQAEEEk Neuromodulin X -Csnk2a1 CK2A1 P19139 rat CPT1A 25757 P32198 Cpt1a rat S741 479870 FHISSKFsSPETDsH Carn_acyltransf X -Csnk2a1 CK2A1 P19139 rat PAM 25508 P14925 Pam rat S949 453092 DRVstEGsDQEKDED X -Csnk2a1 CK2A1 P19139 rat DEK 7913 P35659 DEK human S251 476135 sDDEDKEsEEEPPKK X -Csnk2a1 CK2A1 P19139 rat SYT1 25716 P21707 Syt1 rat T112 448549 DVKDLGKtMKDQALK X -STK3 MST2 Q13188 human GR 2908 P04150 NR3C1 human S682 1872513508 VPkDGLksQELFDEI Hormone_recep X -STK3 MST2 Q13188 human PKCA 5578 P17252 PRKCA human S226 2050181 LNPQWNEsFtFkLKP C2 X -STK3 MST2 Q13188 human Abl 25 P00519 ABL1 human T735 450291 DTEWRSVtLPRDLQS X 2864 -STK3 MST2 Q13188 human MOB1B 92597 Q7L9L4 MOB1B human T74 11555108 QINMLYGtITDFCTE Mob1_phocein X -STK3 MST2 Q13188 human SAV1 60485 Q9H4B6 SAV1 human S36 21507300 LLRNLMPsFIRHGPT X -STK3 MST2 Q13188 human GR 2908 P04150 NR3C1 human T562 1872513501 StWRIMTtLNMLGGR Hormone_recep X -STK3 MST2 Q13188 human MOB1A 55233 Q9H8S9 MOB1A human T35 3212769 LLkHAEAtLGsGNLR Mob1_phocein X 8699 -STK3 MST2 Q13188 human OBSCN 84033 Q5VST9 OBSCN human T5798 1881579400 AESVVVStAIQEFYK X -STK3 MST2 Q13188 human NEK2 4751 P51955 NEK2 human S406 26367604 NsEsQLtsksKCKDL X -STK3 MST2 Q13188 human MOB1A 55233 Q9H8S9 MOB1A human T12 34669905 FsSRssktFKPkkNI X -STK3 MST2 Q13188 human LC3B 67443 Q9CQV6 Map1lc3b mouse T50 37045604 QLPVLDktkFLVPDH ATG8 X X -STK3 MST2 Q13188 human LATS1 9113 O95835 LATS1 human S909 457594 HQRCLAHsLVGTPNY Pkinase X 9157 -STK3 MST2 Q13188 human H3 360198 P68433 H3c1 mouse S10 455676 tkQTARkstGGkAPr Histone X 9701; 9711; 9606; 3465; 3642; 3377; 3475; 3458; 5764; 47398; 8481; 8552; 53348; 29237; 66065; 43185; 64522; 52725 -STK3 MST2 Q13188 human AMPKA1 5562 Q13131 PRKAA1 human T183 448786 sDGEFLRtsCGsPNy Pkinase X 2535; 2531; 4188; 5256; 50081; 74281 -STK3 MST2 Q13188 human PKCA 5578 P17252 PRKCA human T228 3875546 PQWNEsFtFkLKPsD C2 X -STK3 MST2 Q13188 human SAV1 60485 Q9H4B6 SAV1 human S269 21507301 YRHPCAPsVPRyDQP X -STK3 MST2 Q13188 human MST2 6788 Q13188 STK3 human T378 50592100 DEEEEDGtMKRNAts X -STK3 MST2 Q13188 human SAV1 60485 Q9H4B6 SAV1 human T26 4270990 GKYVKKEtsPLLRNL X -STK3 MST2 Q13188 human GR 2908 P04150 NR3C1 human T668 1872513506 EEYLCMKtLLLLSSV Hormone_recep X -STK3 MST2 Q13188 human LATS1 9113 O95835 LATS1 human T967 1791601 MKVINWQtSLHIPPQ Pkinase X -STK3 MST2 Q13188 human YAP1 10413 P46937 YAP1 human S127 448847 PQHVRAHssPAsLQL X 4911; 13008; 92367; 57706 -STK3 MST2 Q13188 human SAV1 60485 Q9H4B6 SAV1 human S27 7447103 KYVKKEtsPLLRNLM X -STK3 MST2 Q13188 human LATS1 9113 O95835 LATS1 human T1079 457595 EHAFyEFtFRRFFDD X 8654 -STK3 MST2 Q13188 human NEK2 4751 P51955 NEK2 human S365 20721644 LkERkFLsLASNPEL X -STK3 MST2 Q13188 human STAT3 6774 P40763 STAT3 human T622 1877503800 kEGGVTFtWVEkDIS SH2 X X -STK3 MST2 Q13188 human LATS1 9113 O95835 LATS1 human T1060 1791600 EEENVNDtLNGWYKN X -STK3 MST2 Q13188 human MOB1A 55233 Q9H8S9 MOB1A human T74 2506801 QINMLYGtITEFCTE Mob1_phocein X -STK3 MST2 Q13188 human NEK2 4751 P51955 NEK2 human S356 12574602 ENLLkNYsLLkERkF X -STK3 MST2 Q13188 human GR 2908 P04150 NR3C1 human S746 1872513507 TFLDKTMsIEFPEML X -STK3 MST2 Q13188 human LC3B 81631 Q9GZQ8 MAP1LC3B human T50 37045604 QLPVLDktkFLVPDH ATG8 X X -STK3 MST2 Q13188 human MOB1B 92597 Q7L9L4 MOB1B human T35 3545001 LLkHAEAtLGsGNLR Mob1_phocein X X 8699 -STK3 MST2 Q13188 human H3 360198 P68433 H3c1 mouse S28 455677 ATkAArksAPATGGV Histone X 9713 -STK3 MST2 Q13188 human MST2 6788 Q13188 STK3 human T180 448899 DtMAkRNtVIGTPFW Pkinase X 3681; 49332 -STK3 MST2 Q13188 human QSK 23387 Q9Y2K2 SIK3 human T221 456036 TPGQLLKtWCGSPPY Pkinase X -STK3 MST2 Q13188 human LATS1 9113 O95835 LATS1 human T1012 1791603 kAHPFFKtIDFSSDL X -STK3 MST2 Q13188 human LATS1 9113 O95835 LATS1 human S872 1791604 GDHPRQDsMDFSNEW Pkinase X -STK3 MST2 Q13188 human NEK2 4751 P51955 NEK2 human S438 26367603 EkNYQLksRQILGMR X X -STK3 MST2 Q13188 human MOB1B 92597 Q7L9L4 MOB1B human T12 3545000 FGsRssktFKPkkNI X X 8843 -PKM PKM P14618 human MDM2 4193 Q00987 MDM2 human T351 17342607 kAkLENstQAEEGFD X -PKM PKM P14618 human MRLC2V 4633 P10916 MYL2 human Y118 473229 kGVLKADyVREMLtT X X -PKM PKM P14618 human SREBP-1 6720 P36956 SREBF1 human T59 900975702 AGSGAGGtDPAsPDT X -PKM PKM P14618 human STAT3 6774 P40763 STAT3 human Y705 448192 DPGsAAPyLktKFIC X X 4093; 9145; 4324; 9131; 9138; 4323; 4074; 4113; 48313; 20977; 25023; 8119; 52075; 52527; 73533; 61958; 73452; 16185; 74309 -PKM PKM P14618 human CtIP 5932 Q99708 RBBP8 human T126 1275585105 ELMNERNtLQEENKK CtIP_N X X -PKM PKM P14618 human MDM2 4193 Q00987 MDM2 human S166 448130 SsRRRAIsEtEENsD X 3521 -PKM PKM P14618 human PRAS40 84335 Q96B36 AKT1S1 human S203 454572 KRtEARssDEENGPP PRAS X X -PKM PKM P14618 human PRAS40 84335 Q96B36 AKT1S1 human S202 454571 EKRtEARssDEENGP PRAS X X -PKM PKM P14618 human SNAP23 8773 O00161 SNAP23 human S95 455262 NRTkNFEsGkAykTt SNAP-25 X X -TTN Titin Q8WZ42 human Telethonin 21393 O70548 Tcap mouse S157 448693 GPLRRtLsRsMsQEA Telethonin X -AK2 AK2 P54819 human LOXL3 84695 P58215 LOXL3 human S704 1881957100 PNFEVAEsDFTNNAM X -Pak5 PAK5 Q8C015 mouse BAD 12015 Q61337 Bad mouse S112 447860 ETRsRHssyPAGtEE Bcl-2_BAD X X 9291; 5284; 9296; 5193; 11865; 94223 -Prkd2 PRKD2 Q8BZ03 mouse PRKD2 101540 Q8BZ03 Prkd2 mouse S873 448800 QGLAERIsIL_____ X -Prkd2 PRKD2 Q8BZ03 mouse PRKD1 18760 Q62101 Prkd1 mouse S916 447632 KALSERVsIL_____ X 2051; 75148 -AATK Lmr1 Q6ZMQ8 human p53 7157 P04637 TP53 human S366 455223 PGGsRAHssHLkskk X X -Epha4 EphA4 Q03137 mouse EphA4 13838 Q03137 Epha4 mouse Y779 450858 EDDPEAAyttRGGKI PK_Tyr_Ser-Thr X 8793; 8862 -Epha4 EphA4 Q03137 mouse EphA4 13838 Q03137 Epha4 mouse Y928 450651 QAIKMDRyKDNFTAA SAM_2 X -Dyrk1a DYRK1A Q63470 rat Tau iso8 4137 P10636-8 MAPT human T231 449079 KKVAVVRtPPKsPss X 20473; 71429 -Dyrk1a DYRK1A Q63470 rat Tau iso8 4137 P10636-8 MAPT human S199 447927 GDRsGyssPGsPGtP X 29957 -Dyrk1a DYRK1A Q63470 rat DYRK1A 25255 Q63470 Dyrk1a rat Y321 448553 LGQRIyQyIQsRFYR Pkinase X X -Dyrk1a DYRK1A Q63470 rat Tau iso8 4137 P10636-8 MAPT human S396 449081 GAEIVyKsPVVsGDt X 9632 -Dyrk1a DYRK1A Q63470 rat Tau iso8 4137 P10636-8 MAPT human S404 449082 PVVsGDtsPRHLsNV X 35834; 20194; 98523; 91600; 49562 -Dyrk1a DYRK1A Q63470 rat N-WASP 682507 O08816 Wasl rat T259 23003804 IyDFIEKtGGVEAVK X -Dyrk1a DYRK1A Q63470 rat DYRK1A 25255 Q63470 Dyrk1a rat Y219 2869605 KHDTEMKyYIVHLKR Pkinase X -Dyrk1a DYRK1A Q63470 rat DYN1 140694 P21575 Dnm1 rat S795 447604 VPPARPGsRGPAPGP X -Dyrk1a DYRK1A Q63470 rat Tau iso8 4137 P10636-8 MAPT human S202 447928 sGyssPGsPGtPGsR X 39357; 30505 -Dyrk1a DYRK1A Q63470 rat N-WASP 682507 O08816 Wasl rat T202 23003803 LtKADIGtPSNFQHI PBD X -Dyrk1a DYRK1A Q63470 rat H3F3A 3020 P84243 H3-3A human T45 18545304 PHryrPGtVALrEIR Histone X -Dyrk1a DYRK1A Q63470 rat Tau iso8 4137 P10636-8 MAPT human T217 449078 sRtPsLPtPPtREPK X 33134; 51625 -Dyrk1a DYRK1A Q63470 rat N-WASP 682507 O08816 Wasl rat T196 23003801 KAKKKRLtKADIGtP X -Dyrk1a DYRK1A Q63470 rat Tau iso8 4137 P10636-8 MAPT human T181 447932 ktPPAPktPPssGEP X 12885; 66224; 62672 -Dyrk1a DYRK1A Q63470 rat Tau iso8 4137 P10636-8 MAPT human T212 447934 tPGsRsRtPsLPtPP X -Dyrk1a DYRK1A Q63470 rat Tau iso8 4137 P10636-8 MAPT human T205 447933 ssPGsPGtPGsRsRt X 25377; 43964; 53001; 49561; 20060; 33032; 30505; 20739; 98160 -Dyrk1a DYRK1A Q63470 rat Tau iso8 4137 P10636-8 MAPT human S422 449083 GsIDMVDsPQLAtLA X -BLVRA BVR P53004 human BVR 644 P53004 BLVRA human Y83 455762 ESSSHEDyIRQFLNA GFO_IDH_MocA X -BLVRA BVR P53004 human BVR 644 P53004 BLVRA human Y72 455761 SQEVEVAyICSESSS GFO_IDH_MocA X -BLVRA BVR P53004 human PKCB 5579 P05771 PRKCB human T500 447896 WDGVttktFCGtPDy Pkinase X X 9379; 2060; 38938 -ABL2 Arg P42684 human SHP-2 19247 P35235 Ptpn11 mouse Y279 474206 ENKNKNRyKNILPFD Y_phosphatase X -ABL2 Arg P42684 human Catalase 847 P04040 CAT human Y231 450444 NANGEAVyCkFHYkT Catalase X X -ABL2 Arg P42684 human Catalase 12359 P24270 Cat mouse Y386 450445 yRARVANyQRDGPMC Catalase X -ABL2 Arg P42684 human HRas 3265 P01112 HRAS human Y137 41198101 AQDLARSyGIPYIEt Ras X -ABL2 Arg P42684 human CRK 1398 P46108 CRK human Y221 447951 GGPEPGPyAQPsVNt X 3491 -ABL2 Arg P42684 human Rin1 225870 Q921Q7 Rin1 mouse Y35 450778 KPstDPLyDTPDTRG X -ABL2 Arg P42684 human Tau iso8 4137 P10636-8 MAPT human Y310 464352 GGsVQIVykPVDLsk Tubulin-binding X -ABL2 Arg P42684 human Arg 27 P42684 ABL2 human Y439 447923 RLMtGDtytAHAGAk PK_Tyr_Ser-Thr X -ABL2 Arg P42684 human IkB-beta 81525 Q9JIA3 Nfkbib rat Y161 457691 PRDASDTyLTQSQDH X -ABL2 Arg P42684 human PDGFRB 5159 P09619 PDGFRB human Y686 7437801 IITEyCRyGDLVDyL PK_Tyr_Ser-Thr X -ABL2 Arg P42684 human GPX1 2876 P07203 GPX1 human Y98 455673 EILNSLkyVRPGGGF GSHPx X X -ABL2 Arg P42684 human MICAL2 9645 O94851 MICAL2 human Y463 1875329208 INkNFEQyTLDPGTR X X -ABL2 Arg P42684 human galectin-3 3958 P17931 LGALS3 human Y79 13213701 GAPAPGVyPGPPSGP X X -ABL2 Arg P42684 human Catalase 12359 P24270 Cat mouse Y231 450444 NADGEAVyCkFHYkT Catalase X -ABL2 Arg P42684 human MICAL2 9645 O94851 MICAL2 human Y488 1875329204 PHQVKHLyITKELEH X X -ABL2 Arg P42684 human Arg 27 P42684 ABL2 human Y261 455657 GLVTTLHyPAPKCNK X -ABL2 Arg P42684 human C/EBP-beta 1051 P17676 CEBPB human Y78 9397201 RAIDFsPyLEPLGAP X -ABL2 Arg P42684 human IRF3 3661 Q14653 IRF3 human Y292 1867930600 rLGHCHTyWAVSEEL IRF-3 X -ABL2 Arg P42684 human CRK 417553 Q04929 CRK chicken Y222 447951 GGPEPGPyAQPSINT X -ABL2 Arg P42684 human Catalase 847 P04040 CAT human Y386 450445 yRARVANyQRDGPMC Catalase X X -ABL2 Arg P42684 human PSMA7 5688 O14818 PSMA7 human Y153 456317 QTDPsGtyHAWkANA Proteasome X X -ABL2 Arg P42684 human galectin-3 3958 P17931 LGALS3 human Y118 13213700 AGPLIVPyNLPLPGG Gal-bind_lectin X X -ABL2 Arg P42684 human Tau iso8 4137 P10636-8 MAPT human Y394 487463 DHGAEIVyKsPVVsG X -ABL2 Arg P42684 human SHP-2 19247 P35235 Ptpn11 mouse Y63 455054 IQNTGDyyDLyGGEK SH2 X -ABL2 Arg P42684 human TAZ 25937 Q9GZV5 WWTR1 human Y321 27138200 sGLGLGCySVPTtPE X -ABL2 Arg P42684 human Tau iso8 4137 P10636-8 MAPT human Y197 464351 KsGDRsGyssPGsPG X -ABL2 Arg P42684 human ITGB1 3688 P05556 ITGB1 human Y783 447710 DtGENPIyksAVttV Integrin_b_cyt X X -ABL2 Arg P42684 human Siva 10572 O15304 SIVA1 human Y34 448080 RGVCAERySQEVFEk Siva X X -ABL2 Arg P42684 human MICAL2 9645 O94851 MICAL2 human Y445 1875329206 LAERESLyRLLPQTT X X -ABL2 Arg P42684 human SHP-2 19247 P35235 Ptpn11 mouse Y580 448493 REDsARVyENVGLMQ X X 3703; 5431; 13328 -ATR ATR Q13535 human PARP1 142 P09874 PARP1 human S179 481744 FRPEYsAsQLkGFsL zf-PARP X X -ATR ATR Q13535 human CtIP 5932 Q99708 RBBP8 human T859 27427901 WEVGFPStQTCMERG SAE2 X X -ATR ATR Q13535 human ATRIP 84126 Q8WXE1 ATRIP human S68 454388 EELDTLAsQALsQCP X X -ATR ATR Q13535 human MCC 4163 P23508 MCC human S120 3624826 LRsELsQsQHEVNED X -ATR ATR Q13535 human 53BP1 7158 Q12888 TP53BP1 human T302 460977 PEPEVLstQEDLFDQ X -ATR ATR Q13535 human SIRT7 51547 Q9NRC8 SIRT7 human S134 1871979200 TLLQkGRsVsAADLS SIR2 X -ATR ATR Q13535 human SIRT7 51547 Q9NRC8 SIRT7 human S136 1871979201 LQkGRsVsAADLSEA SIR2 X -ATR ATR Q13535 human RAP80 51720 Q96RL1 UIMC1 human S205 486299 sGsWDQSsQPVFENV X -ATR ATR Q13535 human CUTL1 1523 P39880 CUX1 human S1357 477892 ADtEEPKsQGEAERE X -ATR ATR Q13535 human E2F1 1869 Q01094 E2F1 human S31 447867 ALRLLDSsQIVIISA X -ATR ATR Q13535 human p53 7157 P04637 TP53 human S37 447532 NVLsPLPsQAMDDLM TAD2 X 9289 -ATR ATR Q13535 human MDM2 4193 Q00987 MDM2 human S407 450263 SSSIIyssQEDVKEF X X -ATR ATR Q13535 human XPA 7507 P23025 XPA human S196 460698 RSLEVWGsQEALEEA X X -ATR ATR Q13535 human SP1 6667 P08047 SP1 human S101 767911 DLTATQLsQGANGWQ X -ATR ATR Q13535 human BRCA1 672 P38398 BRCA1 human S1280 767901 QVILAkAsQEHHLsE X -ATR ATR Q13535 human PSF2 51659 Q9Y248 GINS2 human S182 460800 QPLEstQsQDF____ X -ATR ATR Q13535 human MCPH1 79648 Q8NEM0 MCPH1 human S322 36125335 QKQAAGMsQETFEEk Microcephalin X -ATR ATR Q13535 human Chk1 1111 O14757 CHEK1 human S317 447833 ENVkYsssQPEPRTG X X 2344; 8191; 12302 -ATR ATR Q13535 human DBF4 10926 Q9UBU7 DBF4 human S502 23010417 FSTDNSGsQPKQKsD X X -ATR ATR Q13535 human FARSLA 2193 Q9Y285 FARSA human S301 477799 QRVkRtHsQGGyGsQ tRNA-synt_2d X -ATR ATR Q13535 human FANCD2 2177 Q9BXW9 FANCD2 human S717 453231 KDGGPVTsQESGQkL FancD2 X X -ATR ATR Q13535 human NPM1 4869 P06748 NPM1 human S125 459897 AVEEDAEsEDEEEED X -ATR ATR Q13535 human FANCD2 2177 Q9BXW9 FANCD2 human T691 470035 yGLEEYDtQDGIAIN FancD2 X X -ATR ATR Q13535 human p16-INK4A 1029 P42771 CDKN2A human S7 448829 _MEPAAGssMEPSAD X -ATR ATR Q13535 human p16-INK4A 1029 P42771 CDKN2A human S152 448832 IDAAEGPsDIPD___ X -ATR ATR Q13535 human FANCM 104806 Q8BGE5 Fancm mouse S1025 28117600 ASHSAGNsQQNLESN X -ATR ATR Q13535 human Smc1 8243 Q14683 SMC1A human S957 448697 IsQEEGssQGEDsVs SMC_N X 4805; 58052 -ATR ATR Q13535 human SFRS14 10147 Q8IX01 SUGP2 human T7 460968 _MAARRItQEtFDAV X -ATR ATR Q13535 human BRCA1 672 P38398 BRCA1 human S1524 448038 LQNRNYPsQEELIKV X 9009 -ATR ATR Q13535 human BLM 641 P54132 BLM human T99 450958 NAPAGQEtQRGGSkS BLM_N X -ATR ATR Q13535 human FANCD2 2177 Q9BXW9 FANCD2 human T596 460935 RsEsPsLtQERANLS FancD2 X -ATR ATR Q13535 human RFA2 6118 P15927 RPA2 human S72 1854604 RIGNVEIsQVTIVGI X -ATR ATR Q13535 human Artemis 64421 Q96SD1 DCLRE1C human S645 457531 NLSTNADsQsssDFE X -ATR ATR Q13535 human CREB 1385 P16220 CREB1 human S107 451811 sVDsVtDsQKRREIL pKID X X -ATR ATR Q13535 human IRS1 3667 P35568 IRS1 human S270 447566 EFRPRsKsQSssNCs X -ATR ATR Q13535 human FANCA 2175 O15360 FANCA human S1449 460787 AAPDADLsQEPHLF_ X X -ATR ATR Q13535 human MLL 4297 Q03164 KMT2A human S516 4709074 VHPPLPIsQsPENES X X -ATR ATR Q13535 human AKAP12 9590 Q02952 AKAP12 human S732 481957 TDGILAGsQEHDPGQ X -ATR ATR Q13535 human RFA2 6118 P15927 RPA2 human S174 1854605 MVLSkANsQPSAGRA RPA_C X -ATR ATR Q13535 human HUWE1 10075 Q7Z6Z7 HUWE1 human S2391 460925 DEAPsNLsQAstLQA X -ATR ATR Q13535 human NOT2 4848 Q9NZN8 CNOT2 human S101 472440 PQLNRsLsQGtQLPs X -ATR ATR Q13535 human BRCA1 672 P38398 BRCA1 human S1423 448036 AVLEQHGsQPSNSYP X X -ATR ATR Q13535 human Smc1 8243 Q14683 SMC1A human S966 448698 GEDsVsGsQRIssIy SMC_N X -ATR ATR Q13535 human PELP1 27043 Q8IZL8 PELP1 human S1033 472322 LAPEALPsQGEVERE X -ATR ATR Q13535 human RAD17 5884 O75943 RAD17 human S646 447755 ETWSLPLsQNSASEL X X 13404 -ATR ATR Q13535 human Chk1 1111 O14757 CHEK1 human S345 447834 LVQGIsFsQPtCPDH X X 2341; 2348; 12268; 76784 -ATR ATR Q13535 human MDC1 9656 Q14676 MDC1 human S513 460753 PGIHLERsQAsTtVD X -ATR ATR Q13535 human SARS 6301 P49591 SARS1 human S241 482693 MQEVAQLsQFDEELy X X -ATR ATR Q13535 human Fe65 322 O00213 APBB1 human S228 36841900 DSSWATLsQGSPSYG X -ATR ATR Q13535 human BRCA1 672 P38398 BRCA1 human S1143 767900 PMGSSHAsQVCSETP X -ATR ATR Q13535 human SMARCC2 6601 Q8TAQ2 SMARCC2 human S969 15707400 PPALPPGsQPIPPTG X -ATR ATR Q13535 human 53BP1 7158 Q12888 TP53BP1 human S176 483994 GFGVLELsQsQDVEE X -ATR ATR Q13535 human DBC-1 57805 Q8N163 CCAR2 human T454 453498 AAEAAPPtQEAQGET DBC1 X 4880 -ATR ATR Q13535 human 53BP1 7158 Q12888 TP53BP1 human S166 483993 GAEDTASsQLGFGVL X -ATR ATR Q13535 human MCM3 4172 P25205 MCM3 human S535 475983 ATDDPNFsQEDQQDT X -ATR ATR Q13535 human NBS1 4683 O60934 NBN human S343 448605 TtPGPsLsQGVsVDE X X 3001 -ATR ATR Q13535 human DNAPK 5591 P78527 PRKDC human T2609 448710 LtPMFVEtQAsQGtL DNAPKcs_CC5 X -ATR ATR Q13535 human ZDHHC13 54503 Q8IUH4 ZDHHC13 human S8 41455513 MEGPGLGsQCRNHSH X -ATR ATR Q13535 human SARS 6301 P49591 SARS1 human S101 23141783 ALANLkVsQIKKVRL Seryl_tRNA_N X X -ATR ATR Q13535 human CEP164 22897 Q9UPV0 CEP164 human S186 2201409 LGELMLPsQGLKTSA X X -ATR ATR Q13535 human p16-INK4A 1029 P42771 CDKN2A human S140 448831 AAGGTrGsNHARIDA Ank_2 X -ATR ATR Q13535 human Chk1 1111 O14757 CHEK1 human S296 447832 GFskHIQsNLDFsPV X 2349; 90178 -ATR ATR Q13535 human FANCI 55215 Q9NVI1 FANCI human S565 114809700 CsQSLSVsQVHVDVH FANCI_HD2 X -ATR ATR Q13535 human Artemis 64421 Q96SD1 DCLRE1C human S516 460660 SSTVAGGsQsPKLFS X -ATR ATR Q13535 human CTF18 63922 Q8WVB6 CHTF18 human S74 478125 PAAsVGssQGGARKR X -ATR ATR Q13535 human SRPK1 6732 Q96SB4 SRPK1 human S408 1872827400 QNGDSSTsQETDSCT X -ATR ATR Q13535 human SIRT7 209011 Q8BKJ9 Sirt7 mouse S137 1871979201 LQKGRPVsAADLSEA SIR2 X -ATR ATR Q13535 human BRCA1 672 P38398 BRCA1 human S1457 450008 SEKAVLTsQKsSEYP X -ATR ATR Q13535 human XPA 7507 P23025 XPA human S173 460697 VKkNPHHsQWGDMKL XPA_C X -ATR ATR Q13535 human KIFC1 3833 Q9BW19 KIFC1 human S26 477789 RPLIkAPsQLPLsGs X -ATR ATR Q13535 human XRCC2 7516 O43543 XRCC2 human S247 482708 FFSkQDDsQsSNQFS Rad51 X -ATR ATR Q13535 human 53BP1 7158 Q12888 TP53BP1 human S452 483996 PGSLPIPsQPQFSHD X -ATR ATR Q13535 human DNAPK 5591 P78527 PRKDC human T2647 448713 QQHDFtLtQTADGRs DNAPKcs_CC5 X -ATR ATR Q13535 human MCC 4163 P23508 MCC human S118 3624820 SELRsELsQsQHEVN X -ATR ATR Q13535 human DNAPK 5591 P78527 PRKDC human S2612 448711 MFVEtQAsQGtLQtR DNAPKcs_CC5 X -ATR ATR Q13535 human p16-INK4A 1029 P42771 CDKN2A human S8 448830 MEPAAGssMEPSADW X -ATR ATR Q13535 human FANCM 57697 Q8IYD8 FANCM human S1045 28117600 LSHSAVNsQQNLELN X -ATR ATR Q13535 human DCK 1633 P27707 DCK human S74 456305 EFEELtMsQkNGGNV dNK X 40371 -ATR ATR Q13535 human RFA2 6118 P15927 RPA2 human S33 448339 GFGsPAPsQAEkkSR X X 10148 -ATR ATR Q13535 human DBF4 10926 Q9UBU7 DBF4 human T449 23010416 DDIRQNFtQLPLHkN X X -ATR ATR Q13535 human SMARCAL1 50485 Q9NZC9 SMARCAL1 human S652 23146560 RLkSDVLsQLPAkQR SNF2-rel_dom X -ATR ATR Q13535 human PCAF 8850 Q92831 KAT2B human S264 1870426001 YWHLEAPsQRRLRsP PCAF_N X -ATR ATR Q13535 human p53 iso2 22059 Q80ZA1 Trp53 mouse S18 447490 ISLELPLsQETFSGL P53_TAD X -ATR ATR Q13535 human BLM 641 P54132 BLM human T122 450959 PKEVVCTtQNtPtVk BLM_N X -ATR ATR Q13535 human RASSF1 iso2 11186 Q9NS23-2 RASSF1 human S131 486364 EWETPDLsQAEIEQK X -ATR ATR Q13535 human RBM21 64852 Q9H6E5 TUT1 human S750 477956 HEAAQEWsQGEAGKG X -ATR ATR Q13535 human ATM 472 Q13315 ATM human S1981 448797 sLAFEEGsQSTtIss X X 4526; 5883; 13050 -ATR ATR Q13535 human USP28 57646 Q96RU2 USP28 human S714 467253 ESSTNSSsQDYSTsQ X -ATR ATR Q13535 human FANCD2 2177 Q9BXW9 FANCD2 human T608 470036 NLSDEQCtQVTSLLQ FancD2 X -ATR ATR Q13535 human Chk2 11200 O96017 CHEK2 human T68 447491 SsLEtVstQELYsIP X X 2197; 2661; 28130; 12812; 82263; 64180; 59068 -ATR ATR Q13535 human SRPK1 6732 Q96SB4 SRPK1 human T326 25724401 ENPPNKMtQEKLEEs X -ATR ATR Q13535 human ATR 545 Q13535 ATR human T1989 2226546 LCFPENEtPPEGkNM FAT X X 58014; 30632 -ATR ATR Q13535 human FANCI 55215 Q9NVI1 FANCI human S559 11952935 SLSSsQCsQSLSVsQ FANCI_HD2 X -ATR ATR Q13535 human RFA2 6118 P15927 RPA2 human T21 448340 yGGAGGYtQsPGGFG X -ATR ATR Q13535 human 53BP1 7158 Q12888 TP53BP1 human S831 452385 EPVEQdssQPsLPLV X -ATR ATR Q13535 human RAD17 5884 O75943 RAD17 human S656 447756 SASELPAsQPQPFSA X X 6981 -ATR ATR Q13535 human WRN 7486 Q14191 WRN human S1141 481875 PEKAYSSsQPVISAQ X -ATR ATR Q13535 human MCM2 4171 P49736 MCM2 human S108 456310 DVEELtAsQREAAER MCM2_N X X -ATR ATR Q13535 human DAXX 1616 Q9UER7 DAXX human S424 477893 EGPsGMAsQGCPsAS X -ATR ATR Q13535 human CtIP 225182 Q80YR6 Rbbp8 mouse T855 27427901 WEVGFPStQTCLERG SAE2 X -ATR ATR Q13535 human RFA2 6118 P15927 RPA2 human S52 1854603 HIVPCTIsQLLSATL X -ATR ATR Q13535 human Chk1 12649 O35280 Chek1 mouse S345 447834 LVQGISFsQPTCPEH X 2341; 2348; 12268; 76784 -ATR ATR Q13535 human POLH 5429 Q9Y253 POLH human S601 18330800 EMDLAHNsQSMHASS X X -ATR ATR Q13535 human DBF4 10926 Q9UBU7 DBF4 human S539 482262 GLItINSsQEHLTVQ X X -ATR ATR Q13535 human NBS1 4683 O60934 NBN human S615 460790 VPEssKIsQENEIGK X -ATR ATR Q13535 human p53 7157 P04637 TP53 human S15 447490 PsVEPPLsQEtFsDL P53_TAD X X 4030; 9235; 9284; 9286; 8695; 8514; 82530; 56979 -ATR ATR Q13535 human SUN2 25777 Q9UH99 SUN2 human S12 448844 SQRLtRysQGDDDGs X -ATR ATR Q13535 human ZSCAN5 79149 Q9BUG6 ZSCAN5A human T422 1279801 DVCQKQFtQKSYLKC zf-met X -ATR ATR Q13535 human PHF14 9678 O94880 PHF14 human S294 472334 tNDsLtLsQsKsNED X -ATR ATR Q13535 human ATRIP 84126 Q8WXE1 ATRIP human S72 454389 TLAsQALsQCPAAAR X X -ATR ATR Q13535 human CCDC82 79780 Q8N4S0 CCDC82 human S154 472592 DDQEKHLsQEDNDLN DUF4196 X -ATR ATR Q13535 human 53BP1 7158 Q12888 TP53BP1 human S178 483995 GVLELsQsQDVEENT X -ATR ATR Q13535 human SIAH1 6477 Q8IUQ4 SIAH1 human S19 2840508 GtSkCPPsQRVPALT X -ATR ATR Q13535 human EWS 2130 Q01844 EWSR1 human T79 7359501 QPPTGYTtPTAPQAY X -ATR ATR Q13535 human BORA 79866 Q6PGQ7 BORA human T501 2512943 QMDsGYNtQNCGSNI X -ATR ATR Q13535 human COPS1 2873 Q13098 GPS1 human S474 467704 ksPPREGsQGELtPA X -ATR ATR Q13535 human XRCC3 7517 O43542 XRCC3 human S225 482710 PFRCEFDsQASAPRA Rad51 X -ATR ATR Q13535 human FANCI 55215 Q9NVI1 FANCI human S556 11952934 VLGSLSSsQCsQSLS FANCI_HD2 X -ATR ATR Q13535 human USP28 57646 Q96RU2 USP28 human S67 467252 DERVkEPsQDtVATE X -ATR ATR Q13535 human VCP 7415 P55072 VCP human S784 456210 NQGGAGPsQGsGGGt X -ATR ATR Q13535 human RFA2 19891 Q62193 Rpa2 mouse S33 448339 GFGsPtPsQAEKKsR X 10148 -ATR ATR Q13535 human WDHD1 11169 O75717 WDHD1 human T826 458395 kAAELTAtQVEEEEE X -ATR ATR Q13535 human MLP 65108 P49006 MARCKSL1 human S71 454298 AIEPAPPsQGAEAKG MARCKS X -STK10 LOK O94804 human Radixin 5962 P35241 RDX human T564 448374 AGRDKyKtLRQIRQG ERM_C X X 3141; 3726; 32600 -STK10 LOK O94804 human Ezrin 7430 P15311 EZR human T567 448104 QGRDkyKtLRQIRQG ERM_C X X 3141; 3726; 32600 -STK10 LOK O94804 human PLK1 5347 P53350 PLK1 human T210 448139 YDGERKktLCGtPNy Pkinase X 4354; 5472; 9062 -STK10 LOK O94804 human Moesin 4478 P26038 MSN human T558 447706 LGRDKyKtLRQIRQG ERM_C X X 3141; 3726; 32600 -LIMK1 LIMK1 P53667 human Destrin 11034 P60981 DSTN human S3 449754 _____MAsGVQVADE X -LIMK1 LIMK1 P53667 human Cofilin-1 29271 P45592 Cfl1 rat S3 448444 _____MAsGVAVsDG X X 3313; 3311 -LIMK1 LIMK1 P53667 human Cofilin-1 1072 P23528 CFL1 human S3 448444 _____MAsGVAVsDG X X 3313; 3311 -Pdk1 PDHK1 Q8BFP9 mouse PDHA1 5160 P08559 PDHA1 human S293 448258 TYRyHGHsMsDPGVs E1_dh X 31866; 37115; 48447 -Prkcd PKCD P28867 mouse HSP27 15507 P14602 Hspb1 mouse S15 448401 FsLLrsPsWEPFRDW X X -Prkcd PKCD P28867 mouse NLRC4 268973 Q3UP24 Nlrc4 mouse S533 25784900 RPLWRQEsIQSLRNT NLRC4_HD X X -Prkcd PKCD P28867 mouse IRS1 16367 P35569 Irs1 mouse S318 451399 MVGGKPGsFRVRASs X 5610 -Prkcd PKCD P28867 mouse NRF2 18024 Q60795 Nfe2l2 mouse S40 450082 SREVFDFsQRQKDYE X -Prkcd PKCD P28867 mouse p40phox 17972 P97369 Ncf4 mouse T154 448266 LRRLRPRtRKIKGVs X 4311 -Prkcd PKCD P28867 mouse JNK1 26419 Q91Y86 Mapk8 mouse S129 464647 ELDHERMsYLLYQML Pkinase X -Prkcd PKCD P28867 mouse PKCD 18753 P28867 Prkcd mouse S643 448591 LNEKPQLsFsDKNLI Pkinase_C X 9376 -Prkcd PKCD P28867 mouse H2B 319187 P10853 H2bc15 mouse S14 449904 APAPkkGskkAVTkA Histone X 6959 -Prkcd PKCD P28867 mouse PXN 19303 Q8VI36 Pxn mouse T572 465506 LKQLNKGtFKEQNDK LIM X X -Prkcd PKCD P28867 mouse STAT3 20848 P42227 Stat3 mouse S727 448191 NtIDLPMsPRTLDSL X 9134; 9136; 34911; 94994; 49081; 58978; 87544; 71958; 50804 -Prkcd PKCD P28867 mouse p53 22059 P02340 Tp53 mouse S18 447490 IsLELPLsQEtFsGL P53_TAD X 9284; 9286; 12571; 56979 -Prkcd PKCD P28867 mouse HSP27 15507 P14602 Hspb1 mouse S86 448403 RALNRQLssGVsEIR X X 2406; 2401; 9709; 11892; 64293 -Prkcd PKCD P28867 mouse PKCG 18752 P63318 Prkcg mouse T514 451041 FPGSttRtFCGtPDy Pkinase X X 9379; 2060; 38938 -Prkcd PKCD P28867 mouse G6PD-2 14380 P97324 G6pd2 mouse T10 1869062303 EQVTLSRtQVCGILR X X -Prkcd PKCD P28867 mouse 14-3-3 zeta 22631 P63101 Ywhaz mouse S58 449833 VVGARRSsWRVVSsI 14-3-3 X X 52631 -Prkcd PKCD P28867 mouse hnRNP K 15387 P61979 Hnrnpk mouse S302 457408 GrGGrGGsrARNLPL X -Prkcd PKCD P28867 mouse 14-3-3 beta 7529 P31946 YWHAB human S60 450226 VVGARRssWRVISsI 14-3-3 X 52631 -Pdgfrb PDGFRB P05622 mouse PIK3R1 18708 P26450 Pik3r1 mouse Y508 451830 QERYSKEyIEKFKRE PI3K_P85_iSH2 X -Pdgfrb PDGFRB P05622 mouse PKCD 18753 P28867 Prkcd mouse Y332 450077 ILDNNGTyGKIWEGS X -Pdgfrb PDGFRB P05622 mouse SH2-B-beta 89817 Q62985 Sh2b1 rat Y439 448753 DRLSQGAyGGLSDRP X -Pdgfrb PDGFRB P05622 mouse PKCD 18753 P28867 Prkcd mouse Y311 447573 TTEsVGIyQGFEKKP X 2055 -Pdgfrb PDGFRB P05622 mouse PKACA 18747 P05132 Prkaca mouse Y331 15230353 DTSNFDDyEEEEIRV X -Pdgfrb PDGFRB P05622 mouse SHP-2 5781 Q06124 PTPN11 human Y542 448492 sKRkGHEytNIKysL X 3751; 94740; 15543; 64117 -Pdgfrb PDGFRB P05622 mouse PDGFRB 18596 P05622 Pdgfrb mouse Y856 447509 DIMRDSNyISkGSTF PK_Tyr_Ser-Thr X 3170 -Pdgfrb PDGFRB P05622 mouse Src 20779 P05480 Src mouse Y138 450213 TGyIPSNyVAPSDSI X X -HCK Hck P08631 human Abl 25 P00519 ABL1 human Y393 450298 RLMtGDtytAHAGAk PK_Tyr_Ser-Thr X 2865 -HCK Hck P08631 human ELMO1 9844 Q92556 ELMO1 human Y216 455872 VLNSHDLyQKVAQEI ELMO_ARM X X -HCK Hck P08631 human STAT5A 6776 P42229 STAT5A human Y694 447767 LAkAVDGyVkPQIkQ X 9365; 9356; 9359; 9351; 4322; 9314; 3939; 40284; 5387; 14603; 66740; 51879; 72712 -HCK Hck P08631 human ADAM15 8751 Q13444 ADAM15 human Y715 451223 LVMLGASyWYRARLH TM X X -HCK Hck P08631 human ELMO1 9844 Q92556 ELMO1 human Y18 455871 AIEWPGAyPkLMEID X X -HCK Hck P08631 human RAPGEF1 2889 Q13905 RAPGEF1 human Y504 448393 APIPSVPyAPFAAIL X X -HCK Hck P08631 human p73 7161 O15350 TP73 human Y28 482867 SLEPDStyFDLPQSS X -HCK Hck P08631 human Abl 25 P00519 ABL1 human Y128 459259 SLEKHSWyHGPVSRN SH2 X -HCK Hck P08631 human 5-LO 240 P09917 ALOX5 human Y95 4113150 LKTPHGDyIEFPCyR PLAT X -HCK Hck P08631 human Abl 11350 P00520 Abl1 mouse Y393 450298 RLMTGDTytAHAGAK PK_Tyr_Ser-Thr X 2865 -HCK Hck P08631 human Abl 25 P00519 ABL1 human Y226 450303 KRNKPtVyGVsPNyD X 2868; 2861 -HCK Hck P08631 human Abl 25 P00519 ABL1 human Y115 450305 QGWVPsNyItPVNSL X -HCK Hck P08631 human Abl 25 P00519 ABL1 human Y215 469589 GLITTLHyPAPKRNK X -HCK Hck P08631 human Abl 25 P00519 ABL1 human Y70 462900 PNLFVALyDFVAsGD SH3_1 X 3098 -HCK Hck P08631 human TBK1 29110 Q9UHD2 TBK1 human Y354 3437786 SSNQELIyEGRRLVL TBK1_ULD X -HCK Hck P08631 human Arg 11352 Q4JIM5 Abl2 mouse Y439 447923 RLMTGDTytAHAGAK PK_Tyr_Ser-Thr X -HCK Hck P08631 human Bcr 613 P11274 BCR human Y177 447792 ADAEKPFyVNVEFHH X 3901 -HCK Hck P08631 human ELMO1 9844 Q92556 ELMO1 human Y720 455565 IPKEPsNyDFVyDCN X X -HCK Hck P08631 human Abl 25 P00519 ABL1 human Y139 456712 VSRNAAEyLLsSGIN SH2 X -HCK Hck P08631 human Hck 3055 P08631 HCK human Y411 448168 RVIEDNEytAREGAk PK_Tyr_Ser-Thr X X 2101; 6943; 59548; 70926; 78740; 94361; 17320 -HCK Hck P08631 human STAT5B 6777 P51692 STAT5B human Y699 448198 tAkAVDGyVkPQIkQ X 9365; 9356; 9359; 9351; 4322; 9314; 3939; 40284; 5387; 14603; 66740; 51879; 72712 -HCK Hck P08631 human Abl 25 P00519 ABL1 human Y172 460505 LRyEGRVyHyRINTA SH2 X -HCK Hck P08631 human 5-LO 240 P09917 ALOX5 human Y54 33670310 ERGAVDSyDVTVDEE PLAT X -HCK Hck P08631 human Abl 25 P00519 ABL1 human Y185 450304 TAsDGKLyVsSESRF SH2 X 3009 -HCK Hck P08631 human ELMO1 9844 Q92556 ELMO1 human Y395 455874 AKHHQDAyIRIVLEN ELMO_CED12 X X -HCK Hck P08631 human ELMO1 9844 Q92556 ELMO1 human Y511 455873 SkLQNLSytEILkIR X X -HCK Hck P08631 human Hck 3055 P08631 HCK human Y522 448322 YTATEsQyQQQP___ X -HCK Hck P08631 human TBK1 29110 Q9UHD2 TBK1 human Y394 126839800 LNTIGLIyEkISLPk TBK1_ULD X -HCK Hck P08631 human 5-LO 240 P09917 ALOX5 human Y43 33670312 HLLDKPFyNDFERGA PLAT X -HCK Hck P08631 human PLCG2 5336 P16885 PLCG2 human Y1217 447939 LNNQLFLyDtHQNLR X X 3871 -HCK Hck P08631 human GRB2 2885 P62993 GRB2 human Y160 452038 QVPQQPtyVQALFDF X -Enpp1 ENPP1 Q924C3 rat ENPP1 85496 Q924C3 Enpp1 rat T238 451402 RPVYPTktFPNHYSI Phosphodiest X -Mos MOS P00536 mouse MEK1 5604 Q02750 MAP2K1 human S222 448513 LIDsMANsFVGtRSY Pkinase X 2338; 9121; 3958; 9154; 16211; 86128; 16780; 75262 -Mos MOS P00536 mouse MOS 17451 P00536 Mos mouse S25 448659 SVDSRSCsIPLVAPR X -Mos MOS P00536 mouse MEK1 5604 Q02750 MAP2K1 human S218 448514 VsGQLIDsMANsFVG Pkinase X 9121; 3958; 9154; 86128 -Mos MOS P00536 mouse MyoD 17927 P10085 Myod1 mouse S237 3188104 YSEAAREsRPGKSAA Myf5 X X -Mos MOS P00536 mouse MOS 17451 P00536 Mos mouse S232 450040 DLRCRQAsPHHIGGT Pkinase X -MAP3K11 MLK3 Q16584 human GLI1 2735 P08151 GLI1 human S1089 1873647706 NMAVGNMsVLLRSLP X X -MAP3K11 MLK3 Q16584 human PIN1 5300 Q13526 PIN1 human S138 25519816 QkPFEDAsFALrTGE Rotamase X X -MAP3K11 MLK3 Q16584 human AMPKA1 5562 Q13131 PRKAA1 human T183 448786 sDGEFLRtsCGsPNy Pkinase X X 2535; 2531; 4188; 5256; 50081; 74281 -MAP3K11 MLK3 Q16584 human MLK3 4296 Q16584 MAP3K11 human T277 448263 LAREWHKtTQMsAAG PK_Tyr_Ser-Thr X -MAP3K11 MLK3 Q16584 human PAK1 5058 Q13153 PAK1 human S204 448173 tKsVyTRsVIEPLPV X X 2605 -MAP3K11 MLK3 Q16584 human PAK1 5058 Q13153 PAK1 human S133 5832238 DVLEFyNsKKtsNsQ X X -MAP3K11 MLK3 Q16584 human MKK4 6416 P45985 MAP2K4 human S257 447654 ISGQLVDsIAKtRDA Pkinase X X 9156; 4514; 59056; 75450 -MAP3K11 MLK3 Q16584 human KIF2A iso1 16563 P28740-1 Kif2a mouse T245 50269505 TRYLENQtFRFDYAF Kinesin X -MAP3K11 MLK3 Q16584 human MLK3 4296 Q16584 MAP3K11 human S281 448262 WHKtTQMsAAGTYAW PK_Tyr_Ser-Thr X -MAP3K11 MLK3 Q16584 human MKK3 5606 P46734 MAP2K3 human S218 448276 IsGyLVDsVAKtMDA Pkinase X 9231; 9236; 12280 -MAP3K11 MLK3 Q16584 human GLI1 2735 P08151 GLI1 human T394 1873647704 HGPDAHVtKRHRGDG X X -MAP3K11 MLK3 Q16584 human MKK4 26398 P47809 Map2k4 mouse T259 447656 LVDsIAKtRDAGCRP Pkinase X 9151; 9156 -MAP3K11 MLK3 Q16584 human MKK4 26398 P47809 Map2k4 mouse S255 447654 ISGQLVDsIAKtRDA Pkinase X 9156; 4514; 59056; 75450 -MAP3K11 MLK3 Q16584 human MKK3 5606 P46734 MAP2K3 human T222 448277 LVDsVAKtMDAGCKP Pkinase X -MAP3K11 MLK3 Q16584 human MKK4 6416 P45985 MAP2K4 human T261 447656 LVDsIAKtRDAGCRP Pkinase X X 9151; 9156 -Tgfbr2 TGFBR2 iso1 Q62312-1 mouse TGFBR1 21812 Q64729 Tgfbr1 mouse S165 448244 VPNEEDPsLDRPFIS X -PDK3 PDHK3 Q15120 human PDHA1 5160 P08559 PDHA1 human S300 448259 sMsDPGVsyRtREEI E1_dh X -PDK3 PDHK3 Q15120 human PDHA1 18597 P35486 Pdha1 mouse S293 448258 TYRyHGHsMsDPGVs E1_dh X 31866; 37115; 48447 -PDK3 PDHK3 Q15120 human PDHA1 5160 P08559 PDHA1 human S293 448258 TYRyHGHsMsDPGVs E1_dh X 31866; 37115; 48447 -PDK3 PDHK3 Q15120 human PDHA2 5161 P29803 PDHA2 human S298 458870 sMsDPGVsyRtREEI E1_dh X -PDK3 PDHK3 Q15120 human PDHA2 5161 P29803 PDHA2 human S291 458869 TYRyHGHsMsDPGVs E1_dh X 31866; 37115; 48447 -Camk2d CAMK2D Q6PHZ2 mouse HDAC5 15184 Q9Z2V6 Hdac5 mouse S488 447996 RPLSRtQsSPLPQSP X 3424 -Camk2d CAMK2D Q6PHZ2 mouse GLO1 109801 Q9CPU0 Glo1 mouse T107 7106304 ELTHNWGtEDDETQS Glyoxalase X -Camk2d CAMK2D Q6PHZ2 mouse PLB 18821 P61014 Pln mouse T17 448115 SAIRRAstIEMPQQA Phospholamban X 8496 -Camk2d CAMK2D Q6PHZ2 mouse MYBPC3 17868 O70468 Mybpc3 mouse S302 471081 sLLKKRDsFRRDskL X X -Camk2d CAMK2D Q6PHZ2 mouse RYR2 20191 E9Q401 Ryr2 mouse S2813 458801 IsQtsQVsIDAAHGY X -Camk2d CAMK2D Q6PHZ2 mouse STX3 20908 Q64704 Stx3 mouse T14 31960301 QLKAKQLtQDDDTDE X -Camk2d CAMK2D Q6PHZ2 mouse GLO1 2739 Q04760 GLO1 human T107 7106304 ELTHNWGtEDDETQS Glyoxalase X -Dyrk3 DYRK3 Q922Y0 mouse DYRK3 226419 Q922Y0 Dyrk3 mouse Y368 451268 EYQKLYtyIQSRFYR Pkinase X -Dyrk3 DYRK3 Q922Y0 mouse CREB 1385 P16220 CREB1 human S119 448228 EILsRRPsyRkILND pKID X 9187; 9196; 9198; 4095; 14228; 14001; 39561; 80120; 44864; 54960; 95995 -ROCK2 ROCK2 O75116 human NHE1 6548 P19634 SLC9A1 human T653 4729330 LRsYNRHtLVADPyE NEXCaM_BD X -ROCK2 ROCK2 O75116 human CRMP-2 395155 Q90635 DPYSL2 chicken T555 448084 DNIPRRTtQRIVAPP X -ROCK2 ROCK2 O75116 human BACE 23621 P56817 BACE1 human S498 450178 DDFADDIsLLk____ X -ROCK2 ROCK2 O75116 human MFN2 64476 Q8R500 Mfn2 rat S442 4746700 AEEIRRLsVLVDEYQ X -ROCK2 ROCK2 O75116 human MRLC2V 4633 P10916 MYL2 human S15 2846506 KRAGGANsNVFsMFE X X -ROCK2 ROCK2 O75116 human SNAP-25 20614 P60879 Snap25 mouse T138 449875 GGFIRRVtNDARENE SNAP-25 X -ROCK2 ROCK2 O75116 human PPP1R14A 94274 Q96A00 PPP1R14A human T38 449098 QkRHARVtVkYDRRE PP1_inhibitor X -ROCK2 ROCK2 O75116 human p47phox 653361 P14598 NCF1 human S320 451726 QRsRKRLsQDAYRRN NECFESHC X X -ROCK2 ROCK2 O75116 human ROCK2 9475 O75116 ROCK2 human S1374 468651 MkIQQNQsIRRPsRQ X -ROCK2 ROCK2 O75116 human endophilin A1 6456 Q99962 SH3GL2 human T14 457634 KKQFHKAtQKVSEKV BAR X X -ROCK2 ROCK2 O75116 human NFAT2 18018 O88942 Nfatc1 mouse S243 4700879 PRHsPSTsPRAsITE X -ROCK2 ROCK2 O75116 human calponin 3 71994 Q9DAW9 Cnn3 mouse S293 4776192 QGtGTNGsEIsDsDy X -ROCK2 ROCK2 O75116 human TNNI3 21954 P48787 Tnni3 mouse T144 451483 RGKFKRPtLRRVRIs Troponin X -ROCK2 ROCK2 O75116 human ROCK2 9475 O75116 ROCK2 human S1366 23003812 ARssPRtsMkIQQNQ X -ROCK2 ROCK2 O75116 human MYPT1 116670 Q10728 Ppp1r12a rat S854 451999 RPREKRRstGVSFWT X -ROCK2 ROCK2 O75116 human LIMK2 3985 P53671 LIMK2 human T505 448683 NDRKKRYtVVGNPYW PK_Tyr_Ser-Thr X 3841 -ROCK2 ROCK2 O75116 human Vimentin 7431 P08670 VIM human S72 449026 ssAVrLrssVPGVRL Filament_head X -ROCK2 ROCK2 O75116 human CRMP-2 25416 P47942 Dpysl2 rat T555 448084 DNIPRRTtQRIVAPP X -ROCK2 ROCK2 O75116 human EEF1A1 1915 P68104 EEF1A1 human T432 2862100 AVRDMrQtVAVGVIk GTP_EFTU_D3 X -ROCK2 ROCK2 O75116 human TNNI3 21954 P48787 Tnni3 mouse S24 448424 APVRRRssANyRAYA Troponin-I_N X -ROCK2 ROCK2 O75116 human p47phox 653361 P14598 NCF1 human S304 449406 GAPPRRssIRNAHsI NECFESHC X X -ROCK2 ROCK2 O75116 human IRF4 16364 Q64287 Irf4 mouse S447 12265165 HRSLRHssIQE____ X -ROCK2 ROCK2 O75116 human MYPT1 4659 O14974 PPP1R12A human T696 448587 ARQsRRstQGVtLtD X 5163 -ROCK2 ROCK2 O75116 human calponin 3 71994 Q9DAW9 Cnn3 mouse S296 4776198 GTNGsEIsDsDyQAE X -ROCK2 ROCK2 O75116 human ROCK2 9475 O75116 ROCK2 human S1379 3892345 NQsIRRPsRQLAPNK X -ROCK2 ROCK2 O75116 human IRF4 16364 Q64287 Irf4 mouse S446 26335000 YHRSLRHssIQE___ X -ROCK2 ROCK2 O75116 human p47phox 653361 P14598 NCF1 human S345 451727 QARPGPQsPGsPLEE X X -ROCK2 ROCK2 O75116 human MYPT1 396020 Q90623 PPP1R12A chicken T695 448587 ARQSRRstQGVTLTD X 5163 -ROCK2 ROCK2 O75116 human SORL1 6653 Q92673 SORL1 human S2206 11546400 APMITGFsDDVPMVI X -ROCK2 ROCK2 O75116 human CRMP-2 1808 Q16555 DPYSL2 human T555 448084 DNIPRRttQRIVAPP X -ROCK2 ROCK2 O75116 human NFAT2 4772 O95644 NFATC1 human S241 4700879 PRHsPSTsPRAsVTE X -ROCK2 ROCK2 O75116 human DAB2 1601 P98082 DAB2 human S723 18008467 KPAPRQVsLPVTkst X -ROCK2 ROCK2 O75116 human APP iso4 351 P05067-4 APP human T654 448201 MLKKKQYtsIHHGVV APP_amyloid X -ROCK2 ROCK2 O75116 human p47phox 653361 P14598 NCF1 human S315 451725 AHsIHQRsRKRLsQD NECFESHC X X -ROCK2 ROCK2 O75116 human TNNI3 21954 P48787 Tnni3 mouse S23 448423 PAPVRRRssANyRAY Troponin-I_N X -ROCK2 ROCK2 O75116 human p47phox 653361 P14598 NCF1 human S328 449404 QDAYRRNsVRFLQQR NECFESHC X X -ROCK2 ROCK2 O75116 human calponin 3 1266 Q15417 CNN3 human S293 4776192 QGtGTNGsEIsDSDy X -ROCK2 ROCK2 O75116 human KIF2A iso1 16563 P28740-1 Kif2a mouse T482 50269511 PFRAsKLtQVLRDsF Kinesin X -ROCK2 ROCK2 O75116 human PPP1R14B 26472 Q96C90 PPP1R14B human T57 1904503 VRRQGKVtVkYDRKE PP1_inhibitor X -ROCK2 ROCK2 O75116 human MYPT1 17931 Q9DBR7 Ppp1r12a mouse T852 452075 PREKRRstGVSFWtQ X 4563 -Csf1r CSFR P09581 mouse CSFR 12978 P09581 Csf1r mouse Y721 448364 ssQGVDTyVEMRPVS PK_Tyr_Ser-Thr X X 3151; 3155; 64191 -Csf1r CSFR P09581 mouse CSFR 12978 P09581 Csf1r mouse Y697 451527 DsEGDssykNIHLEK PK_Tyr_Ser-Thr X X 3399 -Csf1r CSFR P09581 mouse CSFR 12978 P09581 Csf1r mouse Y974 455527 PLLQPNNyQFC____ X -Csf1r CSFR P09581 mouse CSFR 12978 P09581 Csf1r mouse Y807 448365 DIMNDSNyVVkGNAR PK_Tyr_Ser-Thr X X 3154 -Csf1r CSFR P09581 mouse CSFR 12978 P09581 Csf1r mouse Y921 455145 LERRDQDyANLPSSG X 3406 -Csf1r CSFR P09581 mouse CSFR 12978 P09581 Csf1r mouse Y706 451528 NIHLEKKyVRRDsGF PK_Tyr_Ser-Thr X 3080; 14591 -Pak3 PAK3 Q62829 rat PAK3 29433 Q62829 Pak3 rat S50 448125 NKKARLRsIFPGGGD X -Pak3 PAK3 Q62829 rat PAK3 29433 Q62829 Pak3 rat T421 448126 PEQSKRstMVGTPYW Pkinase X 2601 -Pak3 PAK3 Q62829 rat GluR1 50592 P19490 Gria1 rat S863 448566 TSTLPRNsGAGASGG X 8084 -Pak3 PAK3 Q62829 rat SYN1 281510 P17599 SYN1 cow S551 451574 PATRPPAsPsPQRQA X -Pak3 PAK3 Q62829 rat MYO6 17920 Q64331 Myo6 mouse T405 449089 TAGGTKGtVIkVPLk Myosin_head X -Pak3 PAK3 Q62829 rat MEK1 170851 Q01986 Map2k1 rat S298 448284 RtPGRPLsSYGMDSR Pkinase X 9128; 98195 -Pak3 PAK3 Q62829 rat SYN1 281510 P17599 SYN1 cow S605 450236 AGPTRQAsQAGPMPR X -Pak3 PAK3 Q62829 rat PAK3 29433 Q62829 Pak3 rat S139 448123 VNNQKYMsFTSGDKS X 2606 -Pak3 PAK3 Q62829 rat SYN1 281510 P17599 SYN1 cow S9 448378 NYLRRRLsDSNFMAN Synapsin_N X -Pak3 PAK3 Q62829 rat RAF1 5894 P04049 RAF1 human S338 447742 RPRGQRDssyyWEIE X X 9427 -Cdk16 CDK16 Q04735 mouse NSF 18195 P46460 Nsf mouse S569 460358 FPFIKICsPDKMIGF AAA X -Pak4 PAK4 B5DF62 rat TORC1 684527 Q157S1 Crtc1 rat S215 60885604 KAGSRPKsCEVPGIN TORC_M X -MAP3K14 Nik Q99558 human CREB 12912 Q01147 Creb1 mouse S128 448547 RkILNDLssDAPGVP pKID X -MAP3K14 Nik Q99558 human IKKA 1147 O15111 CHUK human S176 447778 AKDVDQGsLCtsFVG Pkinase X X 2078; 2697; 14938; 92255; 36516; 36214 -MAP3K14 Nik Q99558 human G6PD 2539 P11413 G6PD human S486 1871700807 PIPYIYGsRGPtEAD G6PD_C X -MAP3K14 Nik Q99558 human G6PD 2539 P11413 G6PD human S278 1871700805 VAMEKPAsTNSDDVR G6PD_C X -MAP3K14 Nik Q99558 human CREB 12912 Q01147 Creb1 mouse S100 451809 EsEDsQEsVDsVTDs pKID X -MAP3K14 Nik Q99558 human NFkB-p100 4791 Q00653 NFKB2 human S870 450167 kEDsAyGsQsVEQEA X 4810 -MAP3K14 Nik Q99558 human IkB-alpha 4792 P25963 NFKBIA human S32 448203 LLDDRHDsGLDsMkD X 5210; 2859; 9246; 5209 -MAP3K14 Nik Q99558 human ARP2 10097 P61160 ACTR2 human T238 36440501 QKLALEttVLVESYT Actin X X -MAP3K14 Nik Q99558 human Moesin 81521 O35763 Msn rat T558 447706 LGRDKYKtLRQIRQG ERM_C X 3141; 3726; 32600 -MAP3K14 Nik Q99558 human IkB-alpha 4792 P25963 NFKBIA human S36 448204 RHDsGLDsMkDEEyE X 5210; 9246 -MAP3K14 Nik Q99558 human ARP2 10097 P61160 ACTR2 human Y202 38546300 kLLLLRGyAFNHsAD Actin X X -MAP3K14 Nik Q99558 human G6PD 2539 P11413 G6PD human S40 1871700806 IFIIMGAsGDLAKKK G6PD_N X X -MAP3K14 Nik Q99558 human ARP2 10097 P61160 ACTR2 human T237 36440502 EQKLALEttVLVESY Actin X X -MAP3K14 Nik Q99558 human IKKB 3551 O14920 IKBKB human S177 447492 AkELDQGsLCtsFVG Pkinase X 2078; 2697; 2694; 14938; 92255; 36516; 36214 -MAP3K14 Nik Q99558 human IKKB 3551 O14920 IKBKB human S181 447489 DQGsLCtsFVGTLQy Pkinase X 2697; 2694; 14938; 92255; 36516; 36214 -MAP3K14 Nik Q99558 human JAK2 16452 Q62120 Jak2 mouse S633 1880516404 QEFVKFGsLDTyLKK X -MAP3K14 Nik Q99558 human Ezrin 54319 P31977 Ezr rat T567 448104 QGRDKYKtLRQIRQG ERM_C X X 3141; 3726; 32600 -MAP3K14 Nik Q99558 human IKKA 1147 O15111 CHUK human S180 447779 DQGsLCtsFVGTLQY Pkinase X 2697; 14938; 92255; 36516; 36214 -MAP3K14 Nik Q99558 human G6PD 2539 P11413 G6PD human S8 31088663 MAEQVALsrtQVCGI X -MAP3K14 Nik Q99558 human NFkB-p100 4791 Q00653 NFKB2 human S866 450166 tAEVkEDsAyGsQsV X 4810 -RPS6KB1 p70S6K P23443 human BACH2 60468 Q9BYV9 BACH2 human S521 470117 ETRTRTssSCSsYsY X -RPS6KB1 p70S6K P23443 human IRS1 3667 P35568 IRS1 human S636 447506 sGDyMPMsPKsVSAP X X 2388 -RPS6KB1 p70S6K P23443 human NDRG2 57447 Q9UN36 NDRG2 human S350 454251 RsRsRtLsQssEsGt X -RPS6KB1 p70S6K P23443 human KHSRP 8570 Q92945 KHSRP human S395 1876620110 DLLQSLrsGPPGPPG X -RPS6KB1 p70S6K P23443 human PDCD4 27250 Q53EL6 PDCD4 human S67 458381 kRRLRKNssRDsGrG X -RPS6KB1 p70S6K P23443 human p63 8626 Q9H3D4 TP63 human S560 4668108 LARLGCSsCLDYFTT SAM_2 X X -RPS6KB1 p70S6K P23443 human mTOR 2475 P42345 MTOR human S2448 447578 RsRtRtDsysAGQsV X X 2971; 2976; 5536; 54932 -RPS6KB1 p70S6K P23443 human TRB2 28951 Q92519 TRIB2 human S83 29604200 FRAVHLHsGEELVCK Pkinase X -RPS6KB1 p70S6K P23443 human S6 6194 P62753 RPS6 human S240 448094 RLssLRAstsKsEss X X 2215; 5364; 5018; 93315; 5044; 13020; 14236; 9468; 35708; 88441; 34918 -RPS6KB1 p70S6K P23443 human p70S6K 6198 P23443 RPS6KB1 human T412 448607 NQVFLGFtyVAPsVL Pkinase_C X 9206; 9234; 9205; 9209; 97596 -RPS6KB1 p70S6K P23443 human SMN 6606 Q16637 SMN1 human S49 1873529903 AyDkAVAsFkHALkN SMN X X -RPS6KB1 p70S6K P23443 human EEF2K 29904 O00418 EEF2K human S366 447827 sPQVRtLsGSRPPLL X X 3691 -RPS6KB1 p70S6K P23443 human BACH2 60468 Q9BYV9 BACH2 human S520 53354442 LETRTRTssSCSsYs X -RPS6KB1 p70S6K P23443 human Mad1 4084 Q05195 MXD1 human S145 2807903 IERIRMDsIGSTVSS X X -RPS6KB1 p70S6K P23443 human IRS1 3667 P35568 IRS1 human S307 450190 TRRsRtEsItAtsPA X X 2384; 2491 -RPS6KB1 p70S6K P23443 human RMP 8725 O94763 URI1 human S372 1028301 AKRKRKNstGsGHsA X X -RPS6KB1 p70S6K P23443 human Tau iso8 4137 P10636-8 MAPT human S262 447930 NVKskIGstENLkHQ Tubulin-binding X -RPS6KB1 p70S6K P23443 human PDCD4 27250 Q53EL6 PDCD4 human S457 458382 RGRKRFVsEGDGGRL X -RPS6KB1 p70S6K P23443 human IRS1 3667 P35568 IRS1 human S527 447561 RFRKRtHsAGtsPtI X -RPS6KB1 p70S6K P23443 human NCBP1 4686 Q09161 NCBP1 human S7 9764056 _MSRRRHsDENDGGQ X -RPS6KB1 p70S6K P23443 human PGC-1 alpha 19017 O70343 Ppargc1a mouse S568 20612406 PQRMRSRsRsFsRHR X X -RPS6KB1 p70S6K P23443 human IRS1 3667 P35568 IRS1 human S270 447566 EFRPRsKsQSssNCs X X -RPS6KB1 p70S6K P23443 human MDM2 17246 P23804 Mdm2 mouse S163 448130 SSRRRsIsEtEENTD X 3521 -RPS6KB1 p70S6K P23443 human GSK3B 56637 Q9WV60 Gsk3b mouse S9 449111 SGRPRttsFAEsCKP X 9336; 9331; 9327; 9323; 9322; 9325; 5558; 8566; 79774; 8466; 25462; 14026; 14332; 14310; 14630 -RPS6KB1 p70S6K P23443 human EIF4B 75705 Q8BGD9 Eif4b mouse S422 451290 RERsRtGsEssQtGA X 3591 -RPS6KB1 p70S6K P23443 human H2B 3018 P33778 H2BC3 human S36 449903 RKRsRkEsysIyVyk Histone X X -RPS6KB1 p70S6K P23443 human PIP5K1C 23396 O60331 PIP5K1C human T553 487222 QPRYRRRtQssGQDG X X -RPS6KB1 p70S6K P23443 human BAD 64639 O35147 Bad rat S137 447862 PFRGRsRsAPPNLWA Bcl-2_BAD X 9295; 5286; 4366 -RPS6KB1 p70S6K P23443 human SKAR 84271 Q9BY77 POLDIP3 human S385 454011 PRRVNsAsSsNPPAE X X -RPS6KB1 p70S6K P23443 human TRBP 6895 Q15633 TARBP2 human S283 27457469 ILSLRsCsLGsLGAL X -RPS6KB1 p70S6K P23443 human mTOR 2475 P42345 MTOR human T2446 450853 NKRsRtRtDsysAGQ X X -RPS6KB1 p70S6K P23443 human FMR1 2332 Q06787 FMR1 human S500 469583 NSEASNAsETESDHR FXMRP1_C_core X -RPS6KB1 p70S6K P23443 human IRS1 3667 P35568 IRS1 human S1101 453434 GCRRRHssEtFsStP X X -RPS6KB1 p70S6K P23443 human S6 6194 P62753 RPS6 human S244 448095 LRAstsKsEssQK__ X X 2215; 5364; 5018; 93315; 5044; 13020; 14236; 9468; 35708; 88441; 34918 -RPS6KB1 p70S6K P23443 human GSK3B 2932 P49841 GSK3B human S9 449111 SGRPRttsFAEsCkP X 9336; 9331; 9327; 9323; 9322; 9325; 5558; 8566; 79774; 8466; 25462; 14026; 14332; 14310; 14630 -RPS6KB1 p70S6K P23443 human Kaiso 10009 Q86T24 ZBTB33 human T606 34353150 yLSDRSStIPAMkDD X -RPS6KB1 p70S6K P23443 human NDRG2 57447 Q9UN36 NDRG2 human S332 451010 LsRsRtAsLtsAAsV X -RPS6KB1 p70S6K P23443 human BMAL1 11865 Q9WTL8 Bmal1 mouse S42 25230400 CNRKRKGsATDYQLD X 13936 -RPS6KB1 p70S6K P23443 human IRS1 16367 P35569 Irs1 mouse S1097 453434 GCRRRHssEtFSAPt X 2385 -RPS6KB1 p70S6K P23443 human Tau iso8 4137 P10636-8 MAPT human S214 447929 GsRsRtPsLPtPPtR X 77348 -RPS6KB1 p70S6K P23443 human DEPTOR 64798 Q8TB45 DEPTOR human S287 4723848 sMssCGssGyFsssP X X -RPS6KB1 p70S6K P23443 human ER-alpha 2099 P03372 ESR1 human S167 448102 GGRERLAsTNDkGSM Oest_recep X X 64508; 42101 -RPS6KB1 p70S6K P23443 human LTC4S 4056 Q16873 LTC4S human S36 40511991 ARRAFRVsPPLtTGP MAPEG X -RPS6KB1 p70S6K P23443 human S6 6194 P62753 RPS6 human S236 448093 AKRRRLssLRAstsK X X 5006; 4856; 4857; 4858; 4851; 4803; 2211; 3945; 3985; 5316; 4854; 8520; 48319; 40643; 9865; 38573; 14733; 27036; 34411; 62016; 62788; 81736; 97935; 99457; 15448 -RPS6KB1 p70S6K P23443 human MRE11A 4361 P49959 MRE11 human T597 4333497 sQrGrADtGLETSTr X X -RPS6KB1 p70S6K P23443 human CAD 790 P27708 CAD human S1859 451247 PPRIhRAsDPGLPAE X X 12662; 67235; 70307 -RPS6KB1 p70S6K P23443 human GluR1 14799 P23818 Gria1 mouse T858 3362100 NEAIRtstLPRNsGA X -RPS6KB1 p70S6K P23443 human NCBP1 4686 Q09161 NCBP1 human S22 1219020 PHKRRKtsDANEtED X -RPS6KB1 p70S6K P23443 human DEPTOR 64798 Q8TB45 DEPTOR human S286 21697912 ssMssCGssGyFsss X X -RPS6KB1 p70S6K P23443 human EGLN1 54583 Q9GZT9 EGLN1 human S125 7322687 ADPAAAAsPCRAAAG X -RPS6KB1 p70S6K P23443 human CCT2 10576 P78371 CCT2 human S260 472352 GsRVRVDstAkVAEI Cpn60_TCP1 X X -RPS6KB1 p70S6K P23443 human Tau iso8 4137 P10636-8 MAPT human T212 447934 tPGsRsRtPsLPtPP X -RPS6KB1 p70S6K P23443 human PGC-1 alpha 19017 O70343 Ppargc1a mouse S572 6421246 RSRsRsFsRHRSCSR X X -RPS6KB1 p70S6K P23443 human FMR1 14265 P35922 Fmr1 mouse S499 469583 NSEAsNAsETESDHR FXMRP1_C_core X -RPS6KB1 p70S6K P23443 human PIP5K1C 23396 O60331 PIP5K1C human S555 1855423 RYRRRtQssGQDGRP X X -RPS6KB1 p70S6K P23443 human GLI1 2735 P08151 GLI1 human S84 25123902 LTKKRALsISPLSDA X X -RPS6KB1 p70S6K P23443 human MSH6 2956 P52701 MSH6 human S309 4274110 RMVtGNGsLKRKSSR X X -RPS6KB1 p70S6K P23443 human RICTOR 253260 Q6R327 RICTOR human T1135 458276 NRRIRtLtEPsVDFN RICTOR_phospho X X 3806 -RPS6KB1 p70S6K P23443 human SRPK2 6733 P78362 SRPK2 human S494 483631 HDRSRtVsAsstGDL X -RPS6KB1 p70S6K P23443 human NCBP1 4686 Q09161 NCBP1 human T21 480103 QPHKRRKtsDANEtE X -RPS6KB1 p70S6K P23443 human EIF4B 1975 P23588 EIF4B human S422 451290 RERsRtGsEssQtGt X 3591 -RPS6KB1 p70S6K P23443 human S6 6194 P62753 RPS6 human S235 448092 IAKRRRLssLRAsts X X 5006; 4856; 4857; 4858; 4851; 4803; 2211; 3945; 3985; 5316; 4854; 8520; 48319; 40643; 9865; 38573; 14733; 27036; 34411; 62016; 62788; 81736; 97935; 99457; 15448 -RPS6KB1 p70S6K P23443 human SKAR 84271 Q9BY77 POLDIP3 human S383 454010 ELPRRVNsAsSsNPP X X -RPS6KB1 p70S6K P23443 human DEPTOR 64798 Q8TB45 DEPTOR human S291 4723858 CGssGyFsssPtLss X X -RPS6KB1 p70S6K P23443 human DNAJC2 22791 P54103 Dnajc2 mouse S47 469782 KRRNRNAstsFQELE X 12397 -RPS6KB1 p70S6K P23443 human EPRS 2058 P07814 EPRS1 human S999 9720900 NQGGGLsssGAGEGQ X X -RPS6KB1 p70S6K P23443 human CDK1 983 P06493 CDK1 human S39 455465 MkkIRLEsEEEGVPs Pkinase X X -Ulk2 ULK2 Q9QY01 mouse beclin 1 56208 O88597 Becn1 mouse S14 25268704 SSSTMQVsFVCQRCS X 84966 -TRPM7 ChaK1 Q96QT4 human MYH9 4627 P35579 MYH9 human S1808 2482304 VKskykAsItALEAk Myosin_tail_1 X -TRPM7 ChaK1 Q96QT4 human ChaK1 54822 Q96QT4 TRPM7 human T1482 2512905 VssLAGFtDCHRTsI X -TRPM7 ChaK1 Q96QT4 human ChaK1 54822 Q96QT4 TRPM7 human S1258 2512936 AQkAsEAsKVHNEIt X -TRPM7 ChaK1 Q96QT4 human ChaK1 54822 Q96QT4 TRPM7 human S1287 2512918 DDGPVRPsVWKKHGV X -TRPM7 ChaK1 Q96QT4 human ChaK1 54822 Q96QT4 TRPM7 human T1537 2512912 EMPsEEGtLNGLtsP X -TRPM7 ChaK1 Q96QT4 human ChaK1 58800 Q923J1 Trpm7 mouse S1567 455464 NLMRLsQsIPFVPVP X -TRPM7 ChaK1 Q96QT4 human ChaK1 54822 Q96QT4 TRPM7 human S1404 2512922 PPTKFFVstPsQPsC X -TRPM7 ChaK1 Q96QT4 human ChaK1 54822 Q96QT4 TRPM7 human S1387 2512908 KNQKLGssSTsIPHL X -TRPM7 ChaK1 Q96QT4 human ChaK1 54822 Q96QT4 TRPM7 human T1405 2512940 PTKFFVstPsQPsCK X -TRPM7 ChaK1 Q96QT4 human PLCG2 5336 P16885 PLCG2 human T1045 25692905 LQPESMRtEkyDPMP X -TRPM7 ChaK1 Q96QT4 human ANXA1 301 P04083 ANXA1 human S5 452051 ___MAMVsEFLKQAW X -TRPM7 ChaK1 Q96QT4 human RHOA 11848 Q9QUI0 Rhoa mouse S188 449035 ARRGKKKsGCLIL__ X X -TRPM7 ChaK1 Q96QT4 human PLCG2 5336 P16885 PLCG2 human S1164 25692906 AVKSGFRsVPLKNGY C2 X X -TRPM7 ChaK1 Q96QT4 human MYH9 17886 Q8VDD5 Myh9 mouse S1799 2482305 AkLQEMEsAVksKyK Myosin_tail_1 X -TRPM7 ChaK1 Q96QT4 human ChaK1 54822 Q96QT4 TRPM7 human S1390 2512931 KLGssSTsIPHLssP X -TRPM7 ChaK1 Q96QT4 human ChaK1 54822 Q96QT4 TRPM7 human T1435 2512928 KATEGDNtEFGAFVG X -TRPM7 ChaK1 Q96QT4 human ChaK1 54822 Q96QT4 TRPM7 human T1265 2512902 sKVHNEItRELsIsK X -TRPM7 ChaK1 Q96QT4 human ChaK1 54822 Q96QT4 TRPM7 human T1542 2512927 EGtLNGLtsPFKPAM X -TRPM7 ChaK1 Q96QT4 human ChaK1 54822 Q96QT4 TRPM7 human S1463 2512920 sNKIKILsNNNTsEN X -TRPM7 ChaK1 Q96QT4 human EEF2K 29904 O00418 EEF2K human S78 450687 ssGsPANsFHFkEAW X -TRPM7 ChaK1 Q96QT4 human ChaK1 54822 Q96QT4 TRPM7 human T1685 2512925 QRAAQKLtFAFNQMK Alpha_kinase X -TRPM7 ChaK1 Q96QT4 human TMOD1 7111 P28289 TMOD1 human S2 22561901 ______MsyRRELEK X -TRPM7 ChaK1 Q96QT4 human ChaK1 54822 Q96QT4 TRPM7 human S1851 2512937 LNLQPGNsTKESEST X -TRPM7 ChaK1 Q96QT4 human ChaK1 54822 Q96QT4 TRPM7 human S1358 2512933 SSGALFPsAVsPPEL X -TRPM7 ChaK1 Q96QT4 human TMOD1 7111 P28289 TMOD1 human T54 22561900 GLRQKDQtTKAPTGP Tropomodulin X -TRPM7 ChaK1 Q96QT4 human ChaK1 54822 Q96QT4 TRPM7 human S1695 2512916 FNQMKPKsIPYSPRF Alpha_kinase X -TRPM7 ChaK1 Q96QT4 human ChaK1 54822 Q96QT4 TRPM7 human S1468 2512929 ILsNNNTsENtLkRV X -TRPM7 ChaK1 Q96QT4 human ChaK1 58800 Q923J1 Trpm7 mouse S1511 455463 EDsPEVdsKAALLPD X -TRPM7 ChaK1 Q96QT4 human ChaK1 54822 Q96QT4 TRPM7 human S1543 2512904 GtLNGLtsPFKPAMD X -TRPM7 ChaK1 Q96QT4 human ChaK1 54822 Q96QT4 TRPM7 human S1660 2512923 EVVNTWSsIYKEDTV Alpha_kinase X -TRPM7 ChaK1 Q96QT4 human ChaK1 54822 Q96QT4 TRPM7 human S1193 2512911 DDKFHsGsEERIRVT X -TRPM7 ChaK1 Q96QT4 human ChaK1 54822 Q96QT4 TRPM7 human S1477 2512935 NtLkRVssLAGFtDC X -TRPM7 ChaK1 Q96QT4 human ChaK1 54822 Q96QT4 TRPM7 human S1860 2512924 KESESTNsVRLML__ X -TRPM7 ChaK1 Q96QT4 human ChaK1 54822 Q96QT4 TRPM7 human T1471 2512919 NNNTsENtLkRVssL X -TRPM7 ChaK1 Q96QT4 human ChaK1 54822 Q96QT4 TRPM7 human S1569 455464 NLMRLsQsIPFTPVP X -TRPM7 ChaK1 Q96QT4 human ANXA1 327662 P46193 ANXA1 cow S5 452051 ___MAMVsEFLKQAW X -TRPM7 ChaK1 Q96QT4 human ChaK1 54822 Q96QT4 TRPM7 human T1583 2512921 PPRGEPVtVYRLEES X -TRPM7 ChaK1 Q96QT4 human ChaK1 54822 Q96QT4 TRPM7 human T1830 2512906 DLKRNDYtPDkIIFP X -TRPM7 ChaK1 Q96QT4 human ChaK1 58800 Q923J1 Trpm7 mouse S1360 31909861 ALFPSAVsPPELRQR X -TRPM7 ChaK1 Q96QT4 human MYH9 17886 Q8VDD5 Myh9 mouse T1931 2482306 GDLPFVVtRRIVRKG X -TRPM7 ChaK1 Q96QT4 human ChaK1 54822 Q96QT4 TRPM7 human S1615 2512930 CAKIEFLsKEEMGGG X -TRPM7 ChaK1 Q96QT4 human ChaK1 54822 Q96QT4 TRPM7 human S1446 2512907 AFVGHRDsMDLQRFK X -TRPM7 ChaK1 Q96QT4 human MYH9 4627 P35579 MYH9 human S1803 2482303 EMEGtVKskykAsIt Myosin_tail_1 X -TRPM7 ChaK1 Q96QT4 human ChaK1 54822 Q96QT4 TRPM7 human S1456 2512910 LQRFKEtsNKIKILs X -TRPM7 ChaK1 Q96QT4 human ChaK1 54822 Q96QT4 TRPM7 human S1255 2512900 TLTAQkAsEAsKVHN X -TRPM7 ChaK1 Q96QT4 human ChaK1 54822 Q96QT4 TRPM7 human T1455 2512932 DLQRFKEtsNKIKIL X -TRPM7 ChaK1 Q96QT4 human ChaK1 58800 Q923J1 Trpm7 mouse S1403 2512922 PPtKFsVstPsQPSC X -TRPM7 ChaK1 Q96QT4 human ChaK1 54822 Q96QT4 TRPM7 human S1779 2512909 GENLTDPsVIKAEEK Alpha_kinase X -TRPM7 ChaK1 Q96QT4 human ChaK1 54822 Q96QT4 TRPM7 human T1163 2512913 DGPkLFLtEEDQkKL X -TRPM7 ChaK1 Q96QT4 human ChaK1 54822 Q96QT4 TRPM7 human S1476 2512941 ENtLkRVssLAGFtD X -TRPM7 ChaK1 Q96QT4 human ChaK1 54822 Q96QT4 TRPM7 human S1598 2512915 SPNILNNsMSSWSQL X -TRPM7 ChaK1 Q96QT4 human ChaK1 54822 Q96QT4 TRPM7 human S1567 2512914 RNNLMRLsQsIPFTP X -TRPM7 ChaK1 Q96QT4 human MYH9 17886 Q8VDD5 Myh9 mouse S1803 2482303 EMEsAVksKyKASIA Myosin_tail_1 X -TRPM7 ChaK1 Q96QT4 human ChaK1 54822 Q96QT4 TRPM7 human S1191 2512901 EKDDKFHsGsEERIR X -TRPM7 ChaK1 Q96QT4 human ChaK1 54822 Q96QT4 TRPM7 human T1551 2512934 PFKPAMDtNYYYSAV X -TRPM7 ChaK1 Q96QT4 human ChaK1 54822 Q96QT4 TRPM7 human S1493 467645 RTsIPVHsKQAEKIs X -TRPM7 ChaK1 Q96QT4 human ChaK1 54822 Q96QT4 TRPM7 human S1533 2512903 PsNREMPsEEGtLNG X -TRPM7 ChaK1 Q96QT4 human ChaK1 54822 Q96QT4 TRPM7 human T1505 480441 KIsRRPstEDtHEVD X -TRPM7 ChaK1 Q96QT4 human ChaK1 54822 Q96QT4 TRPM7 human S1271 2512926 ItRELsIsKHLAQNL X -TRPM7 ChaK1 Q96QT4 human MYH9 4627 P35579 MYH9 human T1800 2482302 kLQEMEGtVKskykA Myosin_tail_1 X -TRPM7 ChaK1 Q96QT4 human ChaK1 54822 Q96QT4 TRPM7 human T1508 2512938 RRPstEDtHEVDsKA X -TRPM7 ChaK1 Q96QT4 human ChaK1 54822 Q96QT4 TRPM7 human S1407 2512939 KFFVstPsQPsCKsH X -TRPM7 ChaK1 Q96QT4 human ChaK1 54822 Q96QT4 TRPM7 human S1513 455463 EDtHEVDsKAALIPD X -TRPM7 ChaK1 Q96QT4 human ChaK1 54822 Q96QT4 TRPM7 human S1527 2512917 DWLQDRPsNREMPsE X -Acvr1b ALK4 Q61271 mouse TTRAP 51567 O95551 TDP2 human T88 12563300 PkTyVDLtNEEtTDs X -Acvr1b ALK4 Q61271 mouse TTRAP 51567 O95551 TDP2 human T92 12563301 VDLtNEEtTDsTTSK X -MERTK Mer Q12866 human MLKL 197259 Q8NB16 MLKL human Y376 1868624704 DRVkstAyLSPQELE PK_Tyr_Ser-Thr X -MERTK Mer Q12866 human Akt1 207 P31749 AKT1 human S473 447855 RPHFPQFsysAsGtA Pkinase_C X 9271; 3787; 4060; 4051; 5102; 4058; 2336; 2337; 4075; 4070; 5012; 4071; 92982; 5315; 9563; 9018; 12694; 52240; 11962; 15116; 88106; 26580; 68035; 31957; 23430; 20235 -MERTK Mer Q12866 human STAT5A 6776 P42229 STAT5A human Y694 447767 LAkAVDGyVkPQIkQ X 9365; 9356; 9359; 9351; 4322; 9314; 3939; 40284; 5387; 14603; 66740; 51879; 72712 -MERTK Mer Q12866 human STAT3 6774 P40763 STAT3 human Y705 448192 DPGsAAPyLktKFIC X 4093; 9145; 4324; 9131; 9138; 4323; 4074; 4113; 48313; 20977; 25023; 8119; 52075; 52527; 73533; 61958; 73452; 16185; 74309 -MERTK Mer Q12866 human Mer 10461 Q12866 MERTK human Y749 449988 FGLsKKIysGDyyRQ PK_Tyr_Ser-Thr X X 44463 -MERTK Mer Q12866 human STAT5B 6777 P51692 STAT5B human Y699 448198 tAkAVDGyVkPQIkQ X 9365; 9356; 9359; 9351; 4322; 9314; 3939; 40284; 5387; 14603; 66740; 51879; 72712 -MERTK Mer Q12866 human Mer 10461 Q12866 MERTK human Y754 449990 KIysGDyyRQGRIAk PK_Tyr_Ser-Thr X X -MERTK Mer Q12866 human Mer 10461 Q12866 MERTK human Y753 449989 KKIysGDyyRQGRIA PK_Tyr_Ser-Thr X X -MERTK Mer Q12866 human Akt1 207 P31749 AKT1 human T308 447856 kDGAtMKtFCGtPEy Pkinase X 5106; 2965; 9275; 4056; 5056; 13842; 13038; 43506; 48646; 86758; 80722; 77440; 80556 -PAK6 PAK6 Q9NQU5 human PACSIN1 29993 Q9BY11 PACSIN1 human S346 4730476 SQAGDRGsVssYDRG X -PAK6 PAK6 Q9NQU5 human MDM2 4193 Q00987 MDM2 human S186 448131 RQRkRHksDsIsLsF X X -PAK6 PAK6 Q9NQU5 human ICAP1 9270 O14713 ITGB1BP1 human S10 1872961000 RKGKKRHssSsSQSS ICAP-1_inte_bdg X -PAK6 PAK6 Q9NQU5 human MDM2 4193 Q00987 MDM2 human T158 27620700 HLVSRPstSsRRRAI X X -PAK6 PAK6 Q9NQU5 human CTBP2 1488 P56545 CTBP2 human S164 2089803 REGTRVQsVEQIREV 2-Hacid_dh_C; 2-Hacid_dh X -PAK6 PAK6 Q9NQU5 human AR 367 P10275 AR human S579 4275600 YGALTCGsCKVFFKR zf-C4 X X -PAK6 PAK6 Q9NQU5 human CTBP1 1487 Q13363 CTBP1 human S100 2089801 RIIVRIGsGFDNIDI 2-Hacid_dh X -PAK6 PAK6 Q9NQU5 human LIMK1 3984 P53667 LIMK1 human T508 447808 PDRKKRYtVVGNPYW PK_Tyr_Ser-Thr X 3841 -PAK6 PAK6 Q9NQU5 human CTBP1 1487 Q13363 CTBP1 human S158 455351 REGTRVQsVEQIREV 2-Hacid_dh_C; 2-Hacid_dh X -Mark3 MARK3 Q03141 mouse MITF iso8 17342 Q08874-8 Mitf mouse S173 467214 PGLTISNsCPANLPN X -PAK1 PAK1 Q13153 human FXR1 8087 P51114 FXR1 human S420 467926 sERkDELsDWsLAGE FXMRP1_C_core X -PAK1 PAK1 Q13153 human ARPC1B 10095 O15143 ARPC1B human T21 10349703 HAWNkDRtQIAICPN X X -PAK1 PAK1 Q13153 human G-alpha(z) 2781 P19086 GNAZ human S16 451242 EKEAARRsRRIDRHL G-alpha X X -PAK1 PAK1 Q13153 human PAK1 18479 O88643 Pak1 mouse T212 448176 VIEPLPVtPtRDVAt X -PAK1 PAK1 Q13153 human ARHGEF2 9181 Q92974 ARHGEF2 human S886 451365 PVDPRRRsLPAGDAL X X -PAK1 PAK1 Q13153 human MEKK1 4214 Q13233 MAP3K1 human S67 3053616 RQLRKVRsVELDQLP X -PAK1 PAK1 Q13153 human TBCB 1155 Q99426 TBCB human S128 455785 VRsFLKRsKLGRyNE X X -PAK1 PAK1 Q13153 human CRK 1398 P46108 CRK human S41 454189 VFLVRDsstsPGDyV SH2 X -PAK1 PAK1 Q13153 human CTNNB1 1499 P35222 CTNNB1 human S675 457120 QDykKRLsVELtsSL X X 9567; 4176; 68076 -PAK1 PAK1 Q13153 human SHOT1 292139 A0MZ67 Shtn1 rat S101 4761847 NKTLKRIsMLYMAKL X -PAK1 PAK1 Q13153 human GDI2 2665 P50395 GDI2 human T248 1873090100 LSAIyGGtYMLNkPI GDI X -PAK1 PAK1 Q13153 human MICAL1 64780 Q8TDZ2 MICAL1 human S817 5434440 sPERQRLssLNLtPD X -PAK1 PAK1 Q13153 human PXN 5829 P49023 PXN human S258 465488 tQQQtRIsAssAtRE X -PAK1 PAK1 Q13153 human GDI2 2665 P50395 GDI2 human S382 5829589 PIEQkFVsIsDLLVP GDI X -PAK1 PAK1 Q13153 human TBCB 1155 Q99426 TBCB human S65 455784 GVDDKFYskLDQEDA Ubiquitin_2 X X -PAK1 PAK1 Q13153 human PXN iso2 5829 P49023-2 PXN human S272 465466 ELDELMAsLSDFKFM X X -PAK1 PAK1 Q13153 human PLK1 5347 P53350 PLK1 human S49 2715404 EVLVDPRsRRRYVRG X X -PAK1 PAK1 Q13153 human H3 8350 P68431 H3C1 human S10 455676 tkQtArkstGGkAPr Histone X X 9701; 9711; 9606; 3465; 3642; 3377; 3475; 3458; 5764; 47398; 8481; 8552; 53348; 29237; 66065; 43185; 64522; 52725 -PAK1 PAK1 Q13153 human PAK1 5058 Q13153 PAK1 human S204 448173 tKsVyTRsVIEPLPV X 2605 -PAK1 PAK1 Q13153 human Snail1 6615 O95863 SNAI1 human S246 455616 QACARTFsRMsLLHK X X -PAK1 PAK1 Q13153 human NET1 56349 Q9Z206 Net1 mouse S538 1868939200 NLRAQRRsCVVPGVM X -PAK1 PAK1 Q13153 human FLNA 2316 P21333 FLNA human S2292 4911900 FEDRkDGsCGVAYVV Filamin X -PAK1 PAK1 Q13153 human RhoGDI alpha 396 P52565 ARHGDIA human S174 452196 kGMLARGsYsIkSRF Rho_GDI X X -PAK1 PAK1 Q13153 human hnRNP E1 5093 Q15365 PCBP1 human T60 478358 NCPERIItLTGPTNA KH_1 X X -PAK1 PAK1 Q13153 human RAF1 110157 Q99N57 Raf1 mouse S338 447742 RPRGQRDssyyWEIE X 9427 -PAK1 PAK1 Q13153 human Cortactin 2017 Q14247 CTTN human S405 447700 KtQtPPVsPAPQPtE X X -PAK1 PAK1 Q13153 human LC8 8655 P63167 DYNLL1 human S88 454241 VAILLFKsG______ Dynein_light X X -PAK1 PAK1 Q13153 human BAD 12015 Q61337 Bad mouse S112 447860 ETRsRHssyPAGtEE Bcl-2_BAD X 9291; 5284; 9296; 5193; 11865; 94223 -PAK1 PAK1 Q13153 human CTBP1 Q9Z2F5 Ctbp1 rat S147 455351 REGTRVQsVEQIREV 2-Hacid_dh_C; 2-Hacid_dh X -PAK1 PAK1 Q13153 human ARL4A 10124 P40617 ARL4A human S143 1877718400 QDLRNSLsLSEIEKL Arf X X -PAK1 PAK1 Q13153 human NLRP3 114548 Q96P20 NLRP3 human S198 230295300 GKTKTCEsPVSPIKM FISNA X -PAK1 PAK1 Q13153 human ARL4D 379 P49703 ARL4D human S144 23083814 QDQPGALsAAEVEkR Arf X X -PAK1 PAK1 Q13153 human SHARP 23013 Q96T58 SPEN human T3568 455622 EGVARRMtVETDYCL SPOC X X -PAK1 PAK1 Q13153 human ARHGEF2 iso2 9181 Q92974-2 ARHGEF2 human S885 451365 PVDPRRRsLPAGDAL X 14143 -PAK1 PAK1 Q13153 human AurA 6790 O14965 AURKA human S342 457608 QETYKRIsRVEFTFP Pkinase X -PAK1 PAK1 Q13153 human STMN1 3925 P16949 STMN1 human S38 448556 sVPEFPLsPPkKkDL Stathmin X 3426; 4191 -PAK1 PAK1 Q13153 human GIT1 28964 Q9Y2X7 GIT1 human S700 465672 PALEPVRsSLRLLNA GIT1_C X -PAK1 PAK1 Q13153 human STAT5A 20850 P42230 Stat5a mouse S779 448750 DsLDARLsPPAGLFT X -PAK1 PAK1 Q13153 human hnRNP E1 5093 Q15365 PCBP1 human T127 478359 IKEIREStGAQVQVA KH_1 X X -PAK1 PAK1 Q13153 human KIF2A iso1 16563 P28740-1 Kif2a mouse T187 50538801 LDYRPLttADPIDEH X -PAK1 PAK1 Q13153 human Merlin 4771 P35240 NF2 human S518 448282 DTDMKRLsMEIEKEK ERM_C X X 9163; 13281 -PAK1 PAK1 Q13153 human Ebp1 5036 Q9UQ80 PA2G4 human T261 2303906 QyGLkMktSRAFFsE Peptidase_M24 X X -PAK1 PAK1 Q13153 human AML2 864 Q13761 RUNX3 human T209 25526800 ERLRMRVtPstPsPr X X -PAK1 PAK1 Q13153 human RhoGDI alpha 396 P52565 ARHGDIA human S101 452195 LEsFKkQsFVLkEGV Rho_GDI X X -PAK1 PAK1 Q13153 human STMN1 3925 P16949 STMN1 human S16 448554 kELEKrAsGQAFELI Stathmin X X 3353 -PAK1 PAK1 Q13153 human MEK1 5604 Q02750 MAP2K1 human S298 448284 RtPGRPLssyGMDSR Pkinase X X 9128; 98195 -PAK1 PAK1 Q13153 human BAD 572 Q92934 BAD human S99 447862 PFrGrsRsAPPNLWA Bcl-2_BAD X X 9295; 5286; 4366 -PAK1 PAK1 Q13153 human KIF2C 11004 Q99661 KIF2C human S111 25159900 kEsLRsRstRMstVS X X -PAK1 PAK1 Q13153 human AurA 6790 O14965 AURKA human T288 448784 APSsRRttLCGtLDy Pkinase X X 3079; 2914; 13464; 8525 -PAK1 PAK1 Q13153 human NET1 56349 Q9Z206 Net1 mouse S153 455601 TPTkRRssALWSEML X -PAK1 PAK1 Q13153 human RAF1 396245 P05625 RAF1 chicken S339 447743 PRGQRDssyyWEIEA X -PAK1 PAK1 Q13153 human SHOT1 71653 Q8K2Q9 Shtn1 mouse S101 4761847 NKTLKRIsMLYMAKL X -PAK1 PAK1 Q13153 human FLNA 192176 Q8BTM8 Flna mouse S2152 451357 TRRRRAPsVANIGsH Filamin X 4761 -PAK1 PAK1 Q13153 human PGM1 5236 P36871 PGM1 human T467 454029 SANDKVYtVEkADNF X X -PAK1 PAK1 Q13153 human PAK1 5058 Q13153 PAK1 human S199 448172 PRPEHtKsVyTRsVI X X 2605 -PAK1 PAK1 Q13153 human RAF1 5894 P04049 RAF1 human S339 447743 PRGQRDssyyWEIEA X -PAK1 PAK1 Q13153 human ILK 3611 Q13418 ILK human S246 479407 CPRLRIFsHPNVLPV PK_Tyr_Ser-Thr X X -PAK1 PAK1 Q13153 human BAD 572 Q92934 BAD human S75 447860 EIRsRHssyPAGtED Bcl-2_BAD X X 9291; 5284; 9296; 5193; 11865; 94223 -PAK1 PAK1 Q13153 human SHOT1 292139 A0MZ67 Shtn1 rat S249 485709 QNKLKRQsHLLLQSS X -PAK1 PAK1 Q13153 human KIF2C 11004 Q99661 KIF2C human S192 2132102 VNsVRRKsCLVkEVE X X -PAK1 PAK1 Q13153 human PGAM1 5223 P18669 PGAM1 human S23 455496 WNLENrFsGWyDADL His_Phos_1 X X -PAK1 PAK1 Q13153 human RhoGDI alpha 396 P52565 ARHGDIA human S176 1876737500 MLARGsYsIkSRFTD Rho_GDI X -PAK1 PAK1 Q13153 human ELF3 1999 P78545 ELF3 human S207 482811 GTGASRSsHSSDsGG X X -PAK1 PAK1 Q13153 human SHOT1 71653 Q8K2Q9 Shtn1 mouse S249 485709 QNkLKRQsHLLLQSS X -PAK1 PAK1 Q13153 human PGAM2 56012 O70250 Pgam2 mouse S118 4698936 QVkIWRRsFDtPPPP His_Phos_1 X X -PAK1 PAK1 Q13153 human MORC2 22880 Q9Y6X9 MORC2 human S739 3217905 AtPsRKRsVAVsDEE X X -PAK1 PAK1 Q13153 human TIE1 21846 Q06806 Tie1 mouse T794 50596802 LHRRRTFtYQSGSGE X -PAK1 PAK1 Q13153 human Cortactin 2017 Q14247 CTTN human S113 465664 skLskHCsQVDsVrG HS1_rep X -PAK1 PAK1 Q13153 human NLRP3 114548 Q96P20 NLRP3 human T659 1871776517 KIEINLStRMDHMVS X X -PAK1 PAK1 Q13153 human BAD 572 Q92934 BAD human S118 447863 GRELRRMsDEFVDsF Bcl-2_BAD X X 9297 -PAK1 PAK1 Q13153 human GIT1 28964 Q9Y2X7 GIT1 human S508 457607 RRDRQAFsMyEPGsA X -PAK1 PAK1 Q13153 human NRIF3 23421 Q13352 ITGB3BP human S28 2840505 SkITRKKsVITysPT CENP-R X X -PAK1 PAK1 Q13153 human BAD 572 Q92934 BAD human S74 5209400 VEIRsRHssyPAGtE Bcl-2_BAD X X -PAK1 PAK1 Q13153 human NLRP3 114548 Q96P20 NLRP3 human S163 409465601 ARLGEsVsLNKRYTR FISNA X -PAK1 PAK1 Q13153 human MRLC1 10398 P24844 MYL9 human S20 1863500 KRPQRAtsNVFAMFD X 3674; 3671; 3675; 95777 -PAK1 PAK1 Q13153 human FLNA 2316 P21333 FLNA human S2152 451357 tRRRRAPsVANVGsH Filamin X X 4761 -PAK1 PAK1 Q13153 human RAF1 396245 P05625 RAF1 chicken S338 447742 RPRGQRDssyyWEIE X -PAK1 PAK1 Q13153 human Snail2 6591 O43623 SNAI2 human S251 63243400 KNCsKTFsRMsLLHK zf-C2H2 X X -PAK1 PAK1 Q13153 human FLNA 2316 P21333 FLNA human S2370 4753817 AIDAkVHsPsGALEE Filamin X -PAK1 PAK1 Q13153 human BRAF 673 P15056 BRAF human S446 447804 KtLGRRDssDDWEIP X 2696 -PAK1 PAK1 Q13153 human MYPT1 116670 Q10728 Ppp1r12a rat T697 448587 ARQSRRstQGVTLTD X 5163 -PAK1 PAK1 Q13153 human PGAM1 5223 P18669 PGAM1 human S118 455497 QVkIWRRsyDVPPPP His_Phos_1 X X -PAK1 PAK1 Q13153 human JUB 16475 Q91XC0 Ajuba mouse T172 22499900 SRPCSNRtSGISMGY X X -PAK1 PAK1 Q13153 human PPP1R14A 114004 Q99MC0 Ppp1r14a rat T38 449098 QKRHARVtVkYDRRE PP1_inhibitor X -PAK1 PAK1 Q13153 human CTNNB1 1499 P35222 CTNNB1 human S552 472273 QDtQRRtsMGGtQQQ X 9566; 5651 -PAK1 PAK1 Q13153 human SHARP 23013 Q96T58 SPEN human S3486 455623 QPAPKQDssPHLTSQ X X -PAK1 PAK1 Q13153 human Cortactin 2017 Q14247 CTTN human S418 447701 tEErLPssPVyEDAA X X -PAK1 PAK1 Q13153 human KIF2A iso1 16563 P28740-1 Kif2a mouse S479 50269506 PHtPFRAsKLtQVLR Kinesin X -PAK1 PAK1 Q13153 human KIF2A iso1 16563 P28740-1 Kif2a mouse S488 31085778 LtQVLRDsFIGENSR Kinesin X -PAK1 PAK1 Q13153 human NET1 56349 Q9Z206 Net1 mouse S152 455600 PTPTkRRssALWSEM X X -PAK1 PAK1 Q13153 human LIMK1 3984 P53667 LIMK1 human T508 447808 PDRKKRYtVVGNPYW PK_Tyr_Ser-Thr X 3841 -PAK1 PAK1 Q13153 human PAK1 5058 Q13153 PAK1 human S144 448170 sNsQKyMsFtDksAE X X 2606 -PAK1 PAK1 Q13153 human RAF1 5894 P04049 RAF1 human S338 447742 RPRGQRDssyyWEIE X X 9427 -PAK1 PAK1 Q13153 human PREX2 80243 Q70Z35 PREX2 human S1107 35483225 DTISNRDsYSDCNSN X -PAK1 PAK1 Q13153 human BAD 12015 Q61337 Bad mouse S136 447862 PFRGRsRsAPPNLWA Bcl-2_BAD X 9295; 5286; 4366 -PAK1 PAK1 Q13153 human ILK 3611 Q13418 ILK human T173 479406 DTFWkGttRTRPRNG X X -PAK1 PAK1 Q13153 human CTBP1 1487 Q13363 CTBP1 human S158 455351 REGTRVQsVEQIREV 2-Hacid_dh_C; 2-Hacid_dh X X -PAK1 PAK1 Q13153 human PAK1 5058 Q13153 PAK1 human T423 448177 PEQSkRstMVGtPYW Pkinase X X 2601 -PAK1 PAK1 Q13153 human MICAL1 64780 Q8TDZ2 MICAL1 human S960 6226101 ELALRRQssSPEQQK bMERB_dom X -PAK1 PAK1 Q13153 human HACE1 57531 Q8IYU2 HACE1 human S385 10940679 LMKNKRDsTEITsIL X -PAK1 PAK1 Q13153 human ER-alpha 2099 P03372 ESR1 human S305 448805 IkRSkkNsLALSLtA X X -PAK1 PAK1 Q13153 human smMLCK 4638 Q15746 MYLK human S1772 1983833 SGLsGRKsstGsPts X -PAK1 PAK1 Q13153 human KIF2A iso1 16563 P28740-1 Kif2a mouse T186 50538800 SLDYRPLttADPIDE X -PAK1 PAK1 Q13153 human ARHGEF7 114559 O55043 Arhgef7 rat T526 455216 EFAVRKStAALEEDA RhoGEF67_u2 X -PAK1 PAK1 Q13153 human BAD 572 Q92934 BAD human S134 447864 KGLPRPKsAGtAtQM Bcl-2_BAD X X -PAK1 PAK1 Q13153 human PAK1 18479 O88643 Pak1 mouse S144 448170 SNSKKYMsFTDKSAE X 2606 -PAK1 PAK1 Q13153 human Vimentin 7431 P08670 VIM human S56 451514 srsLyAssPGGVyAt Filament_head X X 3877; 7391 -PAK1 PAK1 Q13153 human ATG5 9474 Q9H1Y0 ATG5 human T101 23084709 SALPWNItVHFKSFP APG5 X X -TRPM6 ChaK2 Q9BX84 human H4 8359 P62805 H4C1 human S1 448242 _______sGrGkGGk X X -TRPM6 ChaK2 Q9BX84 human H3 8350 P68431 H3C1 human T3 455678 _____ArtkQtArks Histone X 9714; 13576 -TRPM6 ChaK2 Q9BX84 human H2A.1 8329 P0C0S8 H2AC17 human S1 451190 _______sGrGkQGG Histone X X -TRPM6 ChaK2 Q9BX84 human ChaK2 140803 Q9BX84 TRPM6 human T1851 2255402 FNQVKPQtIPYTPRF Alpha_kinase X -TRPM6 ChaK2 Q9BX84 human H3 8350 P68431 H3C1 human T6 13321500 __ArtkQtArkstGG Histone X -Prkg1 PKG1 A9LNM8 rat CHIP 287155 D4A4T0 Stub1 rat S20 453857 LGtGGGGsPDKsPSA X X -Prkg1 PKG1 A9LNM8 rat VASP 7408 P50552 VASP human S239 448380 GAKLRKVsKQEEASG X 3114; 37565 -RPS6KB1 p70S6K iso2 P23443-2 human GSK3B 2932 P49841 GSK3B human S9 449111 SGRPRttsFAEsCkP X 9336; 9331; 9327; 9323; 9322; 9325; 5558; 8566; 79774; 8466; 25462; 14026; 14332; 14310; 14630 -RPS6KB1 p70S6K iso2 P23443-2 human EPRS 2058 P07814 EPRS1 human S999 9720900 NQGGGLsssGAGEGQ X -WNK1 WNK1 Q9H4A3 human PCF11 51585 O94913 PCF11 human S120 397383603 KSLFKLRstWDEIFP CID X X -WNK1 WNK1 Q9H4A3 human WNK1 65125 Q9H4A3 WNK1 human S382 454105 kRAsFAKsVIGTPEF Pkinase X X -WNK1 WNK1 Q9H4A3 human OSR1 108737 Q6P9R2 Oxsr1 mouse S325 456504 VRRVPGssGRLHKtE X -WNK1 WNK1 Q9H4A3 human KCC3 9990 Q9UHW9 SLC12A6 human T991 4770536 SAYTYERtLMMEQRS SLC12 X -WNK1 WNK1 Q9H4A3 human STLK3 53416 Q9Z1W9 Stk39 mouse T243 456505 tRNKVRKtFVGtPCW Pkinase X -WNK1 WNK1 Q9H4A3 human OSR1 9943 O95747 OXSR1 human S325 456504 VRRVPGssGRLHKtE X -WNK1 WNK1 Q9H4A3 human OSR1 9943 O95747 OXSR1 human T185 456503 TRNKVRktFVGtPCW Pkinase X -WNK1 WNK1 Q9H4A3 human KCC3 9990 Q9UHW9 SLC12A6 human T1048 4770548 YQEKVHMtWTKDKYM SLC12 X -WNK1 WNK1 Q9H4A3 human STLK3 27347 Q9UEW8 STK39 human T231 456505 tRNKVRktFVGtPCW Pkinase X -WNK1 WNK1 Q9H4A3 human PCF11 51585 O94913 PCF11 human T121 397383604 SLFKLRstWDEIFPL CID X X -WNK1 WNK1 Q9H4A3 human STLK3 27347 Q9UEW8 STK39 human S371 456506 VRRVPGssGHLHKTE X -INSR INSR P06213 human IRS1 3667 P35568 IRS1 human Y989 451287 VPssRGDyMTMQMSC X -INSR INSR P06213 human INSR iso2 3643 P06213-2 INSR human Y1173 447680 FGMTRDIyETDyyRK PK_Tyr_Ser-Thr X -INSR INSR P06213 human INSR iso2 3643 P06213-2 INSR human S1302 447677 EENKAPEsEELEMEF X -INSR INSR P06213 human GAB1 2549 Q13480 GAB1 human Y242 455030 FFQQQMIyDsPPSRA X -INSR INSR P06213 human BVR 644 P53004 BLVRA human Y291 455760 LAEEIQkyCCSRK__ X -INSR INSR P06213 human PTEN 5728 P60484 PTEN human Y174 464091 TIPSQRRyVyyysyL X -INSR INSR P06213 human Calmodulin 24242 P0DP29 Calm3 rat Y100 448707 FDkDGNGyIsAAELR EF-hand_7 X -INSR INSR P06213 human ADRB2 101836719 P04274 Adrb2 hamster Y350 449808 RRSSSKAyGNGySSN X -INSR INSR P06213 human PIK3R3 8503 Q92569 PIK3R3 human Y341 451553 NEDADENyFINEEDE X X -INSR INSR P06213 human INSR 3643 P06213 INSR human S1348 447678 GGRDGGSsLGFkRsy X -INSR INSR P06213 human CNGA1 281700 Q00194 CNGA1 cow Y503 27166602 QVySPGDyICKKGDI cNMP_binding X X -INSR INSR P06213 human STXBP3 20912 Q60770 Stxbp3 mouse Y521 459181 RQKPRTNyLELDRKN Sec1 X -INSR INSR P06213 human CEACAM1 81613 P16573 Ceacam1 rat Y488 447777 NKVDDVSySVLNFNA X -INSR INSR P06213 human INSR iso2 3643 P06213-2 INSR human Y1343 447683 sLGFKRSyEEHIPyT X -INSR INSR P06213 human IRS1 3667 P35568 IRS1 human Y896 447556 EPKsPGEyVNIEFGS X 3070 -INSR INSR P06213 human Calmodulin 24242 P0DP29 Calm3 rat Y139 448708 DGDGQVNyEEFVQMM EF-hand_7 X -INSR INSR P06213 human DOK1 1796 Q99704 DOK1 human Y362 448367 DPKEDPIyDEPEGLA X -INSR INSR P06213 human STAT5B 20851 P42232 Stat5b mouse Y699 448198 TAkAADGyVKPQIKQ X 9365; 9356; 9359; 9351; 4322; 9314; 3939; 40284; 5387; 14603; 66740; 51879; 72712 -INSR INSR P06213 human PTEN 5728 P60484 PTEN human Y27 34668100 GFDLDLTyIYPNIIA X -INSR INSR P06213 human IRS2 384783 P81122 Irs2 mouse Y628 457098 YNPyPEDyGDIEIGs X -INSR INSR P06213 human GAB1 2549 Q13480 GAB1 human Y659 447949 VADERVDyVVVDQQK X 12745 -INSR INSR P06213 human GAB1 2549 Q13480 GAB1 human Y373 447945 AsDtDssyCIPTAGM X -INSR INSR P06213 human INSR 3643 P06213 INSR human Y999 447685 yASSNPEyLSASDVF X -INSR INSR P06213 human IRS1 3667 P35568 IRS1 human Y1179 451288 GLENGLNyIDLDLVk X -INSR INSR P06213 human INSR 3643 P06213 INSR human S1314 447677 EENKAPEsEELEMEF X -INSR INSR P06213 human GAB1 2549 Q13480 GAB1 human Y589 449792 SHDSEENyVPMNPNL X -INSR INSR P06213 human PPP2CA 5515 P67775 PPP2CA human Y307 448571 VTRRtPDyFl_____ X -INSR INSR P06213 human INSR 3643 P06213 INSR human Y1355 447683 sLGFkRsyEEHIPyt X 3026 -INSR INSR P06213 human INSR 3643 P06213 INSR human Y1189 447681 RDIyEtDyyRkGGkG PK_Tyr_Ser-Thr X 3024; 3918; 2969 -INSR INSR P06213 human ADRB2 101836719 P04274 Adrb2 hamster Y354 449809 SKAyGNGySSNSNGK X -INSR INSR P06213 human BVR 644 P53004 BLVRA human Y198 455758 EERKEDQyMKMtVCL Biliv-reduc_cat X -INSR INSR P06213 human IRS2 384783 P81122 Irs2 mouse Y624 3597307 PKVAYNPyPEDyGDI X -INSR INSR P06213 human SOCS3 12702 O35718 Socs3 mouse Y204 450446 VNGHLDSyEKVTQLP X -INSR INSR P06213 human BVR 644 P53004 BLVRA human Y228 455759 PGLKRNRyLsFHFks Biliv-reduc_cat X -INSR INSR P06213 human PIK3R1 5295 P27986 PIK3R1 human Y607 448136 NENtEDQysLVEDDE X -INSR INSR P06213 human ARHGAP5 394 Q13017 ARHGAP5 human Y306 449920 NHPDYEEyINLEGTR RhoGAP-FF1 X -INSR INSR P06213 human DOK1 1796 Q99704 DOK1 human Y398 448369 ARVkEEGyELPyNPA X -INSR INSR P06213 human INSR iso2 3643 P06213-2 INSR human Y1177 447681 RDIyETDyyRKGGKG PK_Tyr_Ser-Thr X 3918; 2969 -INSR INSR P06213 human CNGA1 281700 Q00194 CNGA1 cow Y498 450319 LKLQPQVySPGDyIC cNMP_binding X X -INSR INSR P06213 human GAB1 2549 Q13480 GAB1 human Y447 449791 SEELDENyVPMNPNs X -INSR INSR P06213 human GAB1 2549 Q13480 GAB1 human Y472 447947 EPIQEANyVPMtPGT X -INSR INSR P06213 human INSR 3643 P06213 INSR human Y992 451597 DGPLGPLyASSNPEy X -INSR INSR P06213 human INSR iso2 3643 P06213-2 INSR human Y1349 447684 SyEEHIPyTHMNGGK X -INSR INSR P06213 human INSR iso2 3643 P06213-2 INSR human Y1178 447682 DIyETDyyRKGGKGL PK_Tyr_Ser-Thr X 2969 -INSR INSR P06213 human SHP-1 5777 P29350 PTPN6 human Y536 448506 QkGQEsEyGNItyPP X X -INSR INSR P06213 human PHB 5245 P35232 PHB1 human Y114 6374001 FtsIGEDyDERVLPs Band_7 X -INSR INSR P06213 human PIK3R1 5295 P27986 PIK3R1 human Y368 448134 STKMHGDytLTLRKG SH2 X -INSR INSR P06213 human Daple 440193 Q9P219 CCDC88C human Y2025 899136400 PQTVWyEyGCV____ X -INSR INSR P06213 human ADRB2 101836719 P04274 Adrb2 hamster Y364 449810 NSNGKTDyMGEASGC X X -INSR INSR P06213 human IkB-alpha 4792 P25963 NFKBIA human Y42 448737 DsMkDEEyEQMVkEL X -INSR INSR P06213 human GAB1 2549 Q13480 GAB1 human Y285 449801 TEADGELyVFNTPSG X -INSR INSR P06213 human INSR iso2 3643 P06213-2 INSR human S1336 447678 GGRDGGSsLGFKRSy X -INSR INSR P06213 human INSR 3643 P06213 INSR human Y1011 449048 DVFPCSVyVPDEWEV X -INSR INSR P06213 human INSR 3643 P06213 INSR human Y1361 447684 syEEHIPytHMNGGK X 3023 -INSR INSR P06213 human ADRB2 101836719 P04274 Adrb2 hamster Y141 449832 AITSPFKyQSLLTKN 7tm_1 X -INSR INSR P06213 human ADRB2 101836719 P04274 Adrb2 hamster Y132 449831 CVIAVDRyIAITSPF 7tm_1 X -INSR INSR P06213 human PIK3R1 5295 P27986 PIK3R1 human Y580 448135 LRKtRDQyLMWLTQK PI3K_P85_iSH2 X -INSR INSR P06213 human INSR 3643 P06213 INSR human Y1185 447680 FGMTRDIyEtDyyRk PK_Tyr_Ser-Thr X 3021; 80732 -INSR INSR P06213 human GAB1 2549 Q13480 GAB1 human Y627 447948 KGDKQVEyLDLDLDs X 3231; 3233 -INSR INSR P06213 human INSR 3643 P06213 INSR human Y1190 447682 DIyEtDyyRkGGkGL PK_Tyr_Ser-Thr X 3024; 2969 -Musk MUSK Q62838 rat MUSK Q62838 Musk rat Y812 2848303 MAHEEVIyYVRDGNI PK_Tyr_Ser-Thr X -Musk MUSK Q62838 rat MUSK Q62838 Musk rat Y754 2848302 RNIySADyyKADGND PK_Tyr_Ser-Thr X -Musk MUSK Q62838 rat MUSK Q62838 Musk rat Y576 2848301 YPRNNIEyVRDIGEG PK_Tyr_Ser-Thr X -Musk MUSK Q62838 rat MUSK Q62838 Musk rat Y755 2848300 NIySADyyKADGNDA PK_Tyr_Ser-Thr X -Musk MUSK Q62838 rat MUSK Q62838 Musk rat Y553 2848304 RLHPNPMyQRMPLLL X -MAP3K8 Cot P41279 human Radixin 5962 P35241 RDX human T564 448374 AGRDKyKtLRQIRQG ERM_C X 3141; 3726; 32600 -MAP3K8 Cot P41279 human PLCB3 18797 P51432 Plcb3 mouse S537 448450 TSLEPQKsLGEEsLS X 2481; 29021 -MAP3K8 Cot P41279 human IRF3 3661 Q14653 IRF3 human T180 28095000 sPsLDNPtPFPNLGP X -MAP3K8 Cot P41279 human Ezrin 7430 P15311 EZR human T567 448104 QGRDkyKtLRQIRQG ERM_C X 3141; 3726; 32600 -MAP3K8 Cot P41279 human Abl 25 P00519 ABL1 human T735 450291 DTEWRSVtLPRDLQS X 2864 -MAP3K8 Cot P41279 human MEK1 5604 Q02750 MAP2K1 human S222 448513 LIDsMANsFVGtRSY Pkinase X X 2338; 9121; 3958; 9154; 16211; 86128; 16780; 75262 -MAP3K8 Cot P41279 human p90RSK 6195 Q15418 RPS6KA1 human S380 447990 HQLFRGFsFVAtGLM Pkinase_C X 9341; 9335; 13575; 11989; 12032; 75266; 93317; 13397; 13588 -MAP3K8 Cot P41279 human CDK1 983 P06493 CDK1 human T161 447609 GIPIRVytHEVVTLW Pkinase X 9114 -MAP3K8 Cot P41279 human MEK1 5604 Q02750 MAP2K1 human S218 448514 VsGQLIDsMANsFVG Pkinase X X 9121; 3958; 9154; 86128 -MAP3K8 Cot P41279 human PLK1 5347 P53350 PLK1 human S137 448138 LELCRRRsLLELHkR Pkinase X X -MAP3K8 Cot P41279 human IRF3 3661 Q14653 IRF3 human S175 14567912 PQPLRsPsLDNPtPF X -MAP3K8 Cot P41279 human Chk1 1111 O14757 CHEK1 human S345 447834 LVQGIsFsQPtCPDH X 2341; 2348; 12268; 76784 -MAP3K8 Cot P41279 human MEK2 5605 P36507 MAP2K2 human S222 448073 VsGQLIDsMANsFVG Pkinase X X 9121; 3958; 9154; 86128 -MAP3K8 Cot P41279 human NPM1 4869 P06748 NPM1 human T199 448515 VkKsIrDtPAkNAQK X X 3541; 75984 -MAP3K8 Cot P41279 human IRF3 3661 Q14653 IRF3 human S123 4712212 DFSQPDTsPDTNGGG X -MAP3K8 Cot P41279 human MKK3 5606 P46734 MAP2K3 human S218 448276 IsGyLVDsVAKtMDA Pkinase X 9231; 9236; 12280 -MAP3K8 Cot P41279 human CREB 1385 P16220 CREB1 human S119 448228 EILsRRPsyRkILND pKID X 9187; 9196; 9198; 4095; 14228; 14001; 39561; 80120; 44864; 54960; 95995 -MAP3K8 Cot P41279 human eIF4G 1981 Q04637 EIF4G1 human S1147 449800 VVQRssLsRERGEKA X 2441 -MAP3K8 Cot P41279 human MKK6 5608 P52564 MAP2K6 human S207 448194 IsGyLVDsVAKtIDA Pkinase X 9231; 12280 -MAP3K8 Cot P41279 human 4E-BP1 1978 Q13541 EIF4EBP1 human T70 447528 rNsPVtktPPRDLPt eIF_4EBP X 9455; 13396 -MAP3K8 Cot P41279 human PLK1 5347 P53350 PLK1 human T210 448139 YDGERKktLCGtPNy Pkinase X 4354; 5472; 9062 -MAP3K8 Cot P41279 human Cot 26410 Q07174 Map3k8 mouse S141 467688 LTYRNIGsGFVPRGA Pkinase X -MAP3K8 Cot P41279 human Moesin 4478 P26038 MSN human T558 447706 LGRDKyKtLRQIRQG ERM_C X 3141; 3726; 32600 -MAP3K8 Cot P41279 human IRF3 3661 Q14653 IRF3 human S188 30312501 PFPNLGPsENPLkRL X -MAP3K8 Cot P41279 human MEK2 5605 P36507 MAP2K2 human S226 448074 LIDsMANsFVGtRSY Pkinase X X 2338; 9121; 3958; 9154; 16211; 86128; 16780; 75262 -MAP3K8 Cot P41279 human Cot 26410 Q07174 Map3k8 mouse S443 478514 EVLRRQRsLYIDLGA X -MAP3K8 Cot P41279 human H2B 3018 P33778 H2BC3 human S32 447801 DGKkRKRsRkEsysI Histone X -MAP3K8 Cot P41279 human IRF3 3661 Q14653 IRF3 human S173 6370303 PCPQPLRsPsLDNPt X -Rps6ka3 RSK2 P18654 mouse MASTL 67121 Q8C0P0 Mastl mouse T297 1269647500 QCRKRLGtSSTSSQS X -Rps6ka3 RSK2 P18654 mouse H3 360198 P68433 H3c1 mouse S10 455676 tkQTARkstGGkAPr Histone X X 9701; 9711; 9606; 3465; 3642; 3377; 3475; 3458; 5764; 47398; 8481; 8552; 53348; 29237; 66065; 43185; 64522; 52725 -Rps6ka3 RSK2 P18654 mouse H3 8350 P68431 H3C1 human S10 455676 tkQtArkstGGkAPr Histone X 9701; 9711; 9606; 3465; 3642; 3377; 3475; 3458; 5764; 47398; 8481; 8552; 53348; 29237; 66065; 43185; 64522; 52725 -Rps6ka3 RSK2 P18654 mouse Fos 14281 P01101 Fos mouse S362 448481 AAAHRKGsSSNEPSS X -Rps6ka3 RSK2 P18654 mouse CASP8 12370 O89110 Casp8 mouse T265 21258500 KMKDRKGtDCDKEAL Peptidase_C14 X -Rps6ka3 RSK2 P18654 mouse BAD 12015 Q61337 Bad mouse S112 447860 ETRsRHssyPAGtEE Bcl-2_BAD X X 9291; 5284; 9296; 5193; 11865; 94223 -Rps6ka3 RSK2 P18654 mouse ATF-4 11911 Q06507 Atf4 mouse S251 451447 NLPsPGGsRGSPRPK X X -Rps6ka3 RSK2 P18654 mouse p27Kip1 1027 P46527 CDKN1B human T198 448781 PGLRRRQt_______ X X -Rps6ka3 RSK2 P18654 mouse H3 iso3 15081 P84244 H3f3b mouse S10 455676 tKQTARksTGGkAPR Histone X 9701; 9711; 9706; 3465; 3642; 3377; 3475; 3458; 5764; 47398; 8481; 8552; 53348; 29237; 66065; 43185; 64522; 52725 -Rps6ka3 RSK2 P18654 mouse p27Kip1 1027 P46527 CDKN1B human S10 447874 NVRVSNGsPsLErMD X -Rps6ka3 RSK2 P18654 mouse TRAF6 22034 P70196 Traf6 mouse S46 1040254704 SASTGNLsssFMEEI X -Rps6ka3 RSK2 P18654 mouse TRAF6 22034 P70196 Traf6 mouse S48 1040254702 STGNLsssFMEEIQG X -Rps6ka3 RSK2 P18654 mouse MYBPC3 295929 P56741 Mybpc3 rat S288 471080 AGTGRRtsDSHEDAG X -Rps6ka3 RSK2 P18654 mouse HMGN1 15312 P18608 Hmgn1 mouse S7 465531 _MPKRKVsADGAAkA HMG14_17 X -Rps6ka3 RSK2 P18654 mouse RSK2 110651 P18654 Rps6ka3 mouse S386 448065 HQLFRGFsFVAITSD Pkinase_C X 9341; 9335; 13575; 11989; 12032; 75266; 93317; 13397; 13588 -Rps6ka3 RSK2 P18654 mouse C/EBP-beta 24253 P21272 Cebpb rat S273 13373502 QKKVEQLsRELSTLR bZIP_2 X -Rps6ka3 RSK2 P18654 mouse TRAF6 22034 P70196 Traf6 mouse S47 1040254703 ASTGNLsssFMEEIQ X -NUAK2 NuaK2 Q9H093 human LATS1 9113 O95835 LATS1 human S464 451855 NIPVRsNsFNNPLGN X -MAPK9 JNK2 P45984 human YAP1 iso3 10413 P46937-3 YAP1 human T154 3190681 VVSGPAAtPTAQHLR X -MAPK9 JNK2 P45984 human Tau iso8 4137 P10636-8 MAPT human T231 449079 KKVAVVRtPPKsPss X 20473; 71429 -MAPK9 JNK2 P45984 human ATF-2 1386 P15336 ATF2 human T69 448224 sVIVADQtPtPtRFL X X 9225; 94125; 40749; 61584; 44167 -MAPK9 JNK2 P45984 human APP iso4 351 P05067-4 APP human T668 448523 VEVDAAVtPEERHLs APP_amyloid X -MAPK9 JNK2 P45984 human ATF-2 1386 P15336 ATF2 human T71 448225 IVADQtPtPtRFLkN X X 9225; 9221; 5112; 94125; 13850; 40749; 15411; 24329; 61584; 27934; 92109; 20534; 35858 -MAPK9 JNK2 P45984 human JDP2 122953 Q8WYK2 JDP2 human T148 448312 VRtDsVKtPEsEGNP X -MAPK9 JNK2 P45984 human KLF13 51621 Q9Y2Y9 KLF13 human S119 40721820 GAAAAPPsPAWsEPE X -MAPK9 JNK2 P45984 human TOB1 10140 P50616 TOB1 human S154 455536 SSVSSsPsPPFGHSA X -MAPK9 JNK2 P45984 human YAP1 iso3 10413 P46937-3 YAP1 human T119 4959542 AGTAGALtPQHVRAH X -MAPK9 JNK2 P45984 human CTNNB1 12387 Q02248 Ctnnb1 mouse S191 467710 SRHAIMRsPQMVSAI X X -MAPK9 JNK2 P45984 human NFAT3 4776 Q14934 NFATC4 human S217 953803 GLGsPLPsPRAsPRP X -MAPK9 JNK2 P45984 human KLF13 51621 Q9Y2Y9 KLF13 human S123 40721822 APPsPAWsEPEPEAG X -MAPK9 JNK2 P45984 human GR 24413 P06536 Nr3c1 rat S246 451796 LIDENLLsPLAGEDD GCR X 97285 -MAPK9 JNK2 P45984 human PDX1 3651 P52945 PDX1 human S66 458402 QGsPPDIsPYEVPPL X -MAPK9 JNK2 P45984 human LIMD1 8994 Q9UGP4 LIMD1 human S277 451975 RVsPGLPsPNLENGA X X -MAPK9 JNK2 P45984 human LIMD1 8994 Q9UGP4 LIMD1 human S272 451974 TASsQRVsPGLPsPN X X -MAPK9 JNK2 P45984 human Bcl-xL 598 Q07817 BCL2L1 human T115 448162 LTSQLHItPGTAYQS Bcl-2 X -MAPK9 JNK2 P45984 human ATF-2 1386 P15336 ATF2 human S90 467297 GLFNELAsPFENEFk X -MAPK9 JNK2 P45984 human p53 7157 P04637 TP53 human S46 447536 AMDDLMLsPDDIEQW TAD2 X 2521 -MAPK9 JNK2 P45984 human WSTF 9031 Q9UIG0 BAZ1B human S158 3215310 ksDGACDsPssDKEN X -MAPK9 JNK2 P45984 human CDC25C 995 P30307 CDC25C human S168 449022 SEMKyLGsPIttVPK X X -MAPK9 JNK2 P45984 human SERT 6532 P31645 SLC6A4 human T616 7576402 IKsItPEtPTEIPCG X -MAPK9 JNK2 P45984 human YAP1 iso3 10413 P46937-3 YAP1 human S317 471290 GTQNPVSsPGMSQEL X -MAPK9 JNK2 P45984 human BID 637 P55957 BID human T59 448406 EGyDELQtDGNRsSH BID X X -MAPK9 JNK2 P45984 human LIMD1 8994 Q9UGP4 LIMD1 human S421 3214989 LGSVLLDsPssPRVr X X -MAPK9 JNK2 P45984 human PIN1 5300 Q13526 PIN1 human S115 1873647702 sQFSDCssAkARGDL Rotamase X -MAPK9 JNK2 P45984 human PSEN1 5663 P49768 PSEN1 human S319 3397301 NskyNAEstEREsQD Presenilin X X -MAPK9 JNK2 P45984 human Doublecortin iso2 1641 O43602-2 DCX human T321 451361 TSSSQLStPKSKQsP X -MAPK9 JNK2 P45984 human SH3BP5 117186 Q91Y80 Sh3bp5 rat S353 456020 PGSLDLPsPVSLSEF X -MAPK9 JNK2 P45984 human NFAT4 4775 Q12968 NFATC3 human S163 448857 SYRESSLsPsPASSI X X -MAPK9 JNK2 P45984 human Bcl-xL 598 Q07817 BCL2L1 human S62 449099 PSWHLADsPAVNGAT X -MAPK9 JNK2 P45984 human Doublecortin iso2 1641 O43602-2 DCX human S334 451359 sPIStPTsPGSLRkH X 3453; 14053 -MAPK9 JNK2 P45984 human p21Cip1 1026 P38936 CDKN1A human S98 478193 GGRRPGTsPALLQGT X -MAPK9 JNK2 P45984 human IRX3 16373 P81067 Irx3 mouse S389 1874748506 APPTLQLsPAAAAAA X -MAPK9 JNK2 P45984 human BNIP3 84480 Q9ET45 Bnip3 rat T66 4698307 DsPPRSQtPQDTNRA BNIP3 X -MAPK9 JNK2 P45984 human FOXO4 4303 P98177 FOXO4 human T451 448518 PIPKALGtPVLtPPt X -MAPK9 JNK2 P45984 human ATF-2 11909 P16951 Atf2 mouse T51 448224 sVIVADQtPtPtRFL X 9225; 94125; 40749; 61584; 44167 -MAPK9 JNK2 P45984 human SREBP-1 6720 P36956 SREBF1 human S117 469986 YPSMPAFsPGPGIkE X -MAPK9 JNK2 P45984 human GRASP65 64689 Q9BQQ3 GORASP1 human S274 455582 DPLPGPGsPSHsAPD X -MAPK9 JNK2 P45984 human BIM 12125 O54918 Bcl2l11 mouse S65 449330 GPLAPPAsPGPFATR X 4581; 4585 -MAPK9 JNK2 P45984 human Doublecortin iso2 1641 O43602-2 DCX human T331 469976 SKQsPIStPTsPGSL X -MAPK9 JNK2 P45984 human Tau iso8 4137 P10636-8 MAPT human S202 447928 sGyssPGsPGtPGsR X 39357; 30505 -MAPK9 JNK2 P45984 human Myc 4609 P01106 MYC human S86 449991 sRRsGLCsPSyVAVt Myc_N X -MAPK9 JNK2 P45984 human PSEN1 5663 P49768 PSEN1 human T320 3397302 skyNAEstEREsQDT Presenilin X X -MAPK9 JNK2 P45984 human p21Cip1 1026 P38936 CDKN1A human S130 455618 sGEQAEGsPGGPGDs X -MAPK9 JNK2 P45984 human RXRA 6256 P19793 RXRA human S260 450891 NMGLNPssPNDPVtN Hormone_recep X -MAPK9 JNK2 P45984 human YAP1 iso3 10413 P46937-3 YAP1 human S138 485036 SLQLGAVsPGTLTPT X -MAPK9 JNK2 P45984 human Bcl-xL 598 Q07817 BCL2L1 human T47 448163 GTESEMEtPsAINGN X -MAPK9 JNK2 P45984 human TOB1 10140 P50616 TOB1 human S152 455535 PASSVSSsPsPPFGH X -MAPK9 JNK2 P45984 human Tau iso8 4137 P10636-8 MAPT human T217 449078 sRtPsLPtPPtREPK X 33134; 51625 -MAPK9 JNK2 P45984 human BNIP3 84480 Q9ET45 Bnip3 rat S60 17548869 SKSSHCDsPPRSQtP BNIP3 X -MAPK9 JNK2 P45984 human IRX3 16373 P81067 Irx3 mouse S361 1874748504 SLAETATsPDNPRRS X -MAPK9 JNK2 P45984 human NFAT3 4776 Q14934 NFATC4 human S213 953804 ASRFGLGsPLPsPRA X -MAPK9 JNK2 P45984 human NFAT4 4775 Q12968 NFATC3 human S165 448858 RESSLsPsPASSISs X X -MAPK9 JNK2 P45984 human CBX7 52609 Q8VDS3 Cbx7 mouse T119 29669800 TNGPPPWtPTLPSSE CBX7_C X -MAPK9 JNK2 P45984 human Jun 3725 P05412 JUN human S73 447943 VGLLkLAsPELERLI Jun X X 9164; 3270; 8752; 12714; 77955 -MAPK9 JNK2 P45984 human Jun 16476 P05627 Jun mouse S63 447686 kNsDLLtsPDVGLLK Jun X 5464; 9261; 2361; 97721; 91952 -MAPK9 JNK2 P45984 human STMN1 16765 P54227 Stmn1 mouse S38 448556 sVPdFPLsPPKKKDL Stathmin X 3426; 4191 -MAPK9 JNK2 P45984 human p53 7157 P04637 TP53 human S20 447529 PLsQEtFsDLWkLLP P53_TAD X X 9287 -MAPK9 JNK2 P45984 human Tau iso8 4137 P10636-8 MAPT human T181 447932 ktPPAPktPPssGEP X 12885; 66224; 62672 -MAPK9 JNK2 P45984 human HES1 29577 Q04666 Hes1 rat S263 23298200 SVGPNAVsPSSGSSL X -MAPK9 JNK2 P45984 human MAPKAPK5 8550 Q8IW41 MAPKAPK5 human T182 450093 IDQGDLMtPQFtPyY Pkinase X -MAPK9 JNK2 P45984 human MARCKS 4082 P29966 MARCKS human S46 454165 VKVNGDAsPAAAEsG MARCKS X -MAPK9 JNK2 P45984 human Jun 3725 P05412 JUN human S63 447686 kNsDLLtsPDVGLLk Jun X X 5464; 9261; 2361; 97721; 91952 -MAPK9 JNK2 P45984 human ATF-2 11909 P16951 Atf2 mouse T53 448225 IVADQtPtPtRFLKN X 9225; 9221; 5112; 94125; 13850; 40749; 15411; 24329; 61584; 27934; 92109; 20534; 35858 -MAPK9 JNK2 P45984 human SHC1 20416 P98083 Shc1 mouse S36 448508 TPPEELPsPSASSLG X -MAPK9 JNK2 P45984 human Myc 4609 P01106 MYC human S77 448586 LLPtPPLsPsRRsGL Myc_N X 13748 -MAPK9 JNK2 P45984 human CDK4 1019 P11802 CDK4 human T172 448476 YSYQMALtPVVVTLW Pkinase X -MAPK9 JNK2 P45984 human STMN1 16765 P54227 Stmn1 mouse S25 448555 QAFELILsPRskEsV Stathmin X -MAPK9 JNK2 P45984 human PDX1 3651 P52945 PDX1 human S61 458401 LGALEQGsPPDIsPY X -MAPK9 JNK2 P45984 human Tau iso8 4137 P10636-8 MAPT human T212 447934 tPGsRsRtPsLPtPP X -MAPK9 JNK2 P45984 human Oct4 18999 P20263 Pou5f1 mouse S347 25236701 VPVtALGsPMHSN__ X -MAPK9 JNK2 P45984 human CTNNB1 12387 Q02248 Ctnnb1 mouse S605 3545003 LFVQLLYsPIENIQR Arm X X -MAPK9 JNK2 P45984 human TAB1 10454 Q15750 TAB1 human S438 456224 tPTLTNQsPTLtLQS X -MAPK9 JNK2 P45984 human JIP1 9479 Q9UQF2 MAPK8IP1 human T103 449924 LIDAtGDtPGAEDDE X -MAPK9 JNK2 P45984 human LIMD1 8994 Q9UGP4 LIMD1 human S424 3214995 VLLDsPssPRVrLPC X X -MAPK9 JNK2 P45984 human IP3R1 16438 P11881 Itpr1 mouse S1755 450682 RPSGRREsLtsFGNG X 3760; 8548 -MAPK9 JNK2 P45984 human TOB1 10140 P50616 TOB1 human S164 455537 FGHSAAVsPTFMPRS X -MAPK9 JNK2 P45984 human FOXO4 4303 P98177 FOXO4 human T455 448570 ALGtPVLtPPtEAAS X -MAPK9 JNK2 P45984 human GRASP65 56082 O35254 Gorasp1 rat S277 455582 EQLPGPGsPGHGTAD X X -MAPK9 JNK2 P45984 human TIF1A 54700 Q9NYV6 RRN3 human T200 455599 IARYVPstPWFLMPI RRN3 X -MAPK9 JNK2 P45984 human p21Cip1 1026 P38936 CDKN1A human T57 451222 NFDFVtEtPLEGDFA CDI X -MAPK9 JNK2 P45984 human YAP1 iso3 10413 P46937-3 YAP1 human T362 23939103 SSySVPRtPDDFLNS X X -MAPK9 JNK2 P45984 human APLP2 334 Q06481 APLP2 human T736 451599 VEVDPMLtPEERHLN APP_amyloid X -LATS2 LATS2 Q9NRM7 human YAP1 10413 P46937 YAP1 human S397 3190672 tyHSRDEstDsGLsM X X -LATS2 LATS2 Q9NRM7 human p21Cip1 1026 P38936 CDKN1A human S146 447836 GRkRRQtsMTDFyHs X X -LATS2 LATS2 Q9NRM7 human YAP1 22601 P46938 Yap1 mouse S382 3190672 TyHSRDEstDsGLSM X 13619 -LATS2 LATS2 Q9NRM7 human Snail2 6591 O43623 SNAI2 human T208 25311911 QGHIRtHtGEkPFSC X X -LATS2 LATS2 Q9NRM7 human MTF1 4520 Q14872 MTF1 human S152 50784002 EGCPRTysTAGNLRT zf-C2H2 X -LATS2 LATS2 Q9NRM7 human AMOTL2 51421 Q9Y2J4 AMOTL2 human S159 29674704 HGHVRsLsERLLQLs X -LATS2 LATS2 Q9NRM7 human AMOT 27494 Q8VHG2 Amot mouse S176 28699604 QGHVRSLsERLMQMs X -LATS2 LATS2 Q9NRM7 human YAP1 iso2 10413 P46937-2 YAP1 human S109 452305 KsHsRQAstDAGtAG X 46931; 53749 -LATS2 LATS2 Q9NRM7 human YAP1 10413 P46937 YAP1 human S127 448847 PQHVRAHssPAsLQL X 4911; 13008; 92367; 57706 -LATS2 LATS2 Q9NRM7 human TAZ 97064 Q9EPK5 Wwtr1 mouse S89 457660 AQHVRSHssPAsLQL X 75275; 59971 -LATS2 LATS2 Q9NRM7 human YAP1 iso2 10413 P46937-2 YAP1 human S127 448847 PQHVRAHssPASLQL X X 57706 -LATS2 LATS2 Q9NRM7 human YAP1 10413 P46937 YAP1 human S109 452305 ksHsRQAstDAGtAG X 46931; 53749 -LATS2 LATS2 Q9NRM7 human YAP1 iso2 10413 P46937-2 YAP1 human S381 3190672 TYHSRDEsTDsGLsM X 13619 -LATS2 LATS2 Q9NRM7 human TAZ 25937 Q9GZV5 WWTR1 human S89 457660 AQHVRsHssPAsLQL X 75275; 59971 -LATS2 LATS2 Q9NRM7 human Snail1 6615 O95863 SNAI1 human T203 21400402 QGHVRtHtGEkPFSC X X -LATS2 LATS2 Q9NRM7 human INCENP 3619 Q9NQS7 INCENP human S894 450468 RYHKRtssAVWNsPP X -LATS2 LATS2 Q9NRM7 human YAP1 22601 P46938 Yap1 mouse S112 448847 PQHVRAHssPAsLQL X 4911; 13008; 92367; 57706 -LATS2 LATS2 Q9NRM7 human Abl iso2 25 P00519-2 ABL1 human T197 12121095 VYHYRINtASDGKLy SH2 X X -LATS2 LATS2 Q9NRM7 human LATS2 26524 Q9NRM7 LATS2 human S835 28706304 GSHVRQDsMEPSDLW Pkinase X -LATS2 LATS2 Q9NRM7 human CDC26 246184 Q8NHZ8 CDC26 human T7 10815632 _MLRRKPtRLELKLD ANAPC_CDC26 X X -LATS2 LATS2 Q9NRM7 human Raptor 57521 Q8N122 RPTOR human S606 53407301 SAHEkLYsLLSDPIP HEAT X -LATS2 LATS2 Q9NRM7 human PQBP1 10084 O60828 PQBP1 human S247 3175780 FQQRPYPsPGAVLRA X X -LATS2 LATS2 Q9NRM7 human YAP1 iso2 10413 P46937-2 YAP1 human S61 484116 IVHVRGDsEtDLEAL X -LATS2 LATS2 Q9NRM7 human PRPS1 5631 P60891 PRPS1 human S285 1874748500 EDkMKHCsKIQVIDI Pribosyl_synth X X -LATS2 LATS2 Q9NRM7 human 14-3-3 gamma 7532 P61981 YWHAG human S59 3892745 VVGARRSsWRVISsI 14-3-3 X X 52631 -LATS2 LATS2 Q9NRM7 human KIF23 9493 Q02241 KIF23 human S814 470674 LRHRRsRsAGDRWVD MKLP1_Arf_bdg X -LATS2 LATS2 Q9NRM7 human AMOT 154796 Q4VCS5 AMOT human S175 28699604 QGHVRSLsERLMQMS X X -LATS2 LATS2 Q9NRM7 human KIF23 9493 Q02241 KIF23 human S716 453934 QLHRRsNsCsSISVA X -LATS2 LATS2 Q9NRM7 human PRPS2 5634 P11908 PRPS2 human T285 1874748502 EDkMkHCtKIQVIDI Pribosyl_synth X X -LATS2 LATS2 Q9NRM7 human YAP1 iso2 10413 P46937-2 YAP1 human S164 471933 AQHLRQssFEIPDDV X -MLKL MLKL Q8NB16 human CNR2 1269 P34972 CNR2 human S352 450818 kITPWPDsRDLDLSD X -CAMKK2 CAMKK2 Q96RR4 human SIRT1 23411 Q96EB6 SIRT1 human S47 452899 DGPGLERsPGEPGGA X X 2314 -CAMKK2 CAMKK2 Q96RR4 human AMPKA1 65248 P54645 Prkaa1 rat T183 448786 SDGEFLRtsCGSPNY Pkinase X 2535; 2531; 4188; 5256; 50081; 74281 -CAMKK2 CAMKK2 Q96RR4 human AMPKA1 5562 Q13131 PRKAA1 human T183 448786 sDGEFLRtsCGsPNy Pkinase X X 2535; 2531; 4188; 5256; 50081; 74281 -CAMKK2 CAMKK2 Q96RR4 human AMPKA2 108079 Q8BRK8 Prkaa2 mouse T172 448026 sDGEFLRtsCGsPNY Pkinase X X 2535; 2531; 5256; 50081; 74281 -CAMKK2 CAMKK2 Q96RR4 human SIRT1 23411 Q96EB6 SIRT1 human S27 452898 ADREAAssPAGEPLR X X 2327 -CAMKK2 CAMKK2 Q96RR4 human CAMKK2 83506 O88831 Camkk2 rat T482 21336500 KHIPSLAtVILVKTM X -CAMKK2 CAMKK2 Q96RR4 human PACSIN1 29704 Q9Z0W5 Pacsin1 rat T355 20503414 DRGQAYAtEWsDDEs X -CAMKK2 CAMKK2 Q96RR4 human CAMKK2 10645 Q96RR4 CAMKK2 human T85 31873289 GQEVPLDtSGSQARP X X -CAMKK2 CAMKK2 Q96RR4 human AMPKA2 5563 P54646 PRKAA2 human T172 448026 sDGEFLRtsCGsPNy Pkinase X X 2535; 2531; 5256; 50081; 74281 -CAMKK2 CAMKK2 Q96RR4 human Akt1 207 P31749 AKT1 human T308 447856 kDGAtMKtFCGtPEy Pkinase X 5106; 2965; 9275; 4056; 5056; 13842; 13038; 43506; 48646; 86758; 80722; 77440; 80556 -Pak6 PAK6 Q3ULB5 mouse LIMK1 3984 P53667 LIMK1 human T508 447808 PDRKKRYtVVGNPYW PK_Tyr_Ser-Thr X 3841 -MAP4K4 HGK O95819 human Radixin 5962 P35241 RDX human T564 448374 AGRDKyKtLRQIRQG ERM_C X 3141; 3726; 32600 -MAP4K4 HGK O95819 human Ezrin 7430 P15311 EZR human T567 448104 QGRDkyKtLRQIRQG ERM_C X 3141; 3726; 32600 -MAP4K4 HGK O95819 human SMAD1 4086 Q15797 SMAD1 human T322 25802105 sNVNRNStIENTRRH MH2 X X -MAP4K4 HGK O95819 human GR 2908 P04150 NR3C1 human T562 1872513501 StWRIMTtLNMLGGR Hormone_recep X -MAP4K4 HGK O95819 human LATS1 9113 O95835 LATS1 human T1079 457595 EHAFyEFtFRRFFDD X X 8654 -MAP4K4 HGK O95819 human Huntingtin 3064 P42858 HTT human S13 10206805 kLMkAFEsLksFQQQ X X -MAP4K4 HGK O95819 human MLK3 4296 Q16584 MAP3K11 human T738 4271419 EEEPRGGtVsPPPGT X X -MAP4K4 HGK O95819 human ADAM10 102 O14672 ADAM10 human S436 4697183 NNKFSLCsIRNISQV Reprolysin_2 X X -MAP4K4 HGK O95819 human GR 2908 P04150 NR3C1 human T519 1872513502 SENPGNKtIVPAtLP X -MAP4K4 HGK O95819 human Moesin 4478 P26038 MSN human T558 447706 LGRDKyKtLRQIRQG ERM_C X X 3141; 3726; 32600 -MAP4K4 HGK O95819 human Huntingtin 3064 P42858 HTT human T3 10206804 _____MAtLEkLMkA X X -Pak3 PAK3 Q61036 mouse Cortactin 13043 Q60598 Cttn mouse S113 465664 skLSKHCsQVDsVrG HS1_rep X -Pak3 PAK3 Q61036 mouse Cortactin 13043 Q60598 Cttn mouse S282 465666 VQSERQDsSAVGFDy HS1_rep X -Pak3 PAK3 Q61036 mouse Caldesmon 373965 P12957 CALD1 chicken S702 456707 GLKVGVSsRINEWLT Caldesmon X -Pak3 PAK3 Q61036 mouse Cortactin 13043 Q60598 Cttn mouse S150 465665 GKTEKHAsQkDysSG HS1_rep X -Pak3 PAK3 Q61036 mouse Caldesmon 373965 P12957 CALD1 chicken S672 456706 EGVRNIKsMWEKGNV Caldesmon X -Mapkapk3 MAPKAPK3 Q3UMW7 mouse WNK4 65266 Q96J92 WNK4 human S575 53332700 PFLFRHAsYSSTTSD X -Mapkapk3 MAPKAPK3 Q3UMW7 mouse TTP 22695 P22893 Zfp36 mouse S52 451150 RLTGRSTsLVEGRsC X -Mapkapk3 MAPKAPK3 Q3UMW7 mouse TTP 22695 P22893 Zfp36 mouse S178 451151 HVLRQsIsFsGLPsG X -Camk2a CAMK2A P11275 rat CAMK2A 25400 P11275 Camk2a rat T286 447797 sCMHRQEtVDCLkkF X X 12716 -Camk2a CAMK2A P11275 rat Tau iso8 4137 P10636-8 MAPT human T231 449079 KKVAVVRtPPKsPss X 20473; 71429 -Camk2a CAMK2A P11275 rat SAPAP1 65040 P97836 Dlgap1 rat S389 481511 YLKATQPsLTELTTL X -Camk2a CAMK2A P11275 rat EGFR 1956 P00533 EGFR human S768 452119 DEAyVMAsVDNPHVC PK_Tyr_Ser-Thr X -Camk2a CAMK2A P11275 rat Tau iso2 4137 P10636-2 MAPT human S315 449082 PVVSGDTsPRHLsNV X 35834; 20194; 98523; 91600; 49562 -Camk2a CAMK2A P11275 rat EGFR 1956 P00533 EGFR human S1070 448051 DsFLQRyssDPtGAL X 2238 -Camk2a CAMK2A P11275 rat RYR2 689560 B0LPN4 Ryr2 rat S2804 458801 IsQTsQVsIDAAHGY X X -Camk2a CAMK2A P11275 rat DRP1 74006 Q8K1M6 Dnm1l mouse S622 454690 PIPIMPAsPQKGHAV X 3455; 4494; 63940 -Camk2a CAMK2A P11275 rat CAMK2B 24245 P08413 Camk2b rat T287 450048 sMMHRQEtVECLkkF X 12716 -Camk2a CAMK2A P11275 rat SYN1 281510 P17599 SYN1 cow S568 456356 PQATRQTsVSGQAPP X -Camk2a CAMK2A P11275 rat nNOS 24598 P29476 Nos1 rat S847 447886 SYKVRFNsVSSYSDS Flavodoxin_1 X X -Camk2a CAMK2A P11275 rat 14-3-3 beta 56011 P35213 Ywhab rat S65 467269 RSsWRVIsSIEQkTE 14-3-3 X -Camk2a CAMK2A P11275 rat EGFR 1956 P00533 EGFR human S1166 452120 QkGsHQIsLDNPDyQ X -Camk2a CAMK2A P11275 rat Tau iso6 4137 P10636-6 MAPT human S346 449082 PVVSGDTsPRHLSNV X 35834; 20194; 98523; 91600; 49562 -Camk2a CAMK2A P11275 rat Spinophilin 84686 O35274 Ppp1r9b rat S100 448729 LsLPRAssLNENVDH X X -Camk2a CAMK2A P11275 rat SAPAP1 65040 P97836 Dlgap1 rat S691 12130200 KTSSKFQsVGVQVEE GKAP X -Camk2a CAMK2A P11275 rat TH iso4 7054 P07101-4 TH human S44 448545 RFIGRRQsLIEDARK TOH_N X 2791 -Camk2a CAMK2A P11275 rat DLG1 25252 Q62696 Dlg1 rat S39 451614 SSIERVIsIFQSNLF L27_1 X -Camk2a CAMK2A P11275 rat SynGAP 192117 Q9QUH6 Syngap1 rat S1118 481550 kEGsIGGsGGsGGGG DUF3498 X -Camk2a CAMK2A P11275 rat CAMK2B 24245 P08413 Camk2b rat T254 2048065 NLINQMLtINPAkRI Pkinase X -Camk2a CAMK2A P11275 rat PLA2G4A 5321 P47712 PLA2G4A human S515 447598 SDFATQDsFDDDELD PLA2_B X X -Camk2a CAMK2A P11275 rat Tau iso6 4137 P10636-6 MAPT human T173 449079 KKVAVVRtPPKsPSS X 20473; 71429 -Camk2a CAMK2A P11275 rat Tau iso8 4137 P10636-8 MAPT human S396 449081 GAEIVyKsPVVsGDt X 9632 -Camk2a CAMK2A P11275 rat CPEB 293056 P0C279 Cpeb1 rat T171 449610 VRGSRLDtRPILDSR CEBP1_N X X -Camk2a CAMK2A P11275 rat SynGAP 192117 Q9QUH6 Syngap1 rat S1138 451016 PSITkQHsQTPSTLN DUF3498 X -Camk2a CAMK2A P11275 rat Tau iso8 4137 P10636-8 MAPT human S404 449082 PVVsGDtsPRHLsNV X 35834; 20194; 98523; 91600; 49562 -Camk2a CAMK2A P11275 rat kalirin 84009 P97924 Kalrn rat T77 1315601 DVCKRGFtVIIDMRG CRAL_TRIO_2 X X -Camk2a CAMK2A P11275 rat Vimentin 22352 P20152 Vim mouse S83 451816 GVRLLQDsVdFsLAD Filament_head X 3878; 12569 -Camk2a CAMK2A P11275 rat Tau iso8 4137 P10636-8 MAPT human S262 447930 NVKskIGstENLkHQ Tubulin-binding X X -Camk2a CAMK2A P11275 rat TH iso3 7054 P07101-3 TH human S19 448542 KGFRRAVsELDAKQA TOH_N X -Camk2a CAMK2A P11275 rat CAMK4 25050 P13234 Camk4 rat S333 2827403 VkAVVAssRLGsASS X -Camk2a CAMK2A P11275 rat NUMB 8650 P49757 NUMB human S276 456490 EQLARQGsFrGFPAL NumbF X 4140; 9878 -Camk2a CAMK2A P11275 rat Tau iso5 4137 P10636-5 MAPT human T231 449079 KKVAVVRtPPKsPSS X 20473; 71429 -Camk2a CAMK2A P11275 rat CACNB2 116600 Q8VGC3 Cacnb2 rat T549 470081 RGLSRQEtFDsETQE X X -Camk2a CAMK2A P11275 rat PSD-95 29495 P31016 Dlg4 rat S73 471390 ITLERGNsGLGFSIA PDZ X -Camk2a CAMK2A P11275 rat TPH2 121278 Q8IWU9 TPH2 human S19 470085 YWARRGFsLDSAVPE X -Camk2a CAMK2A P11275 rat GABRG2 14406 P22723 Gabrg2 mouse S393 452034 TIDIRPRsAtIQMNN Neur_chan_memb X -Camk2a CAMK2A P11275 rat TH iso4 7054 P07101-4 TH human S19 448542 KGFRRAVsELDAKQA TOH_N X -Camk2a CAMK2A P11275 rat GABRG2 14406 P22723 Gabrg2 mouse S381 452033 NPLLRMFsFKAPTID Neur_chan_memb X -Camk2a CAMK2A P11275 rat GluR1 50592 P19490 Gria1 rat S849 448565 FCLIPQQsINEAIrT X X 75574 -Camk2a CAMK2A P11275 rat SynGAP 192117 Q9QUH6 Syngap1 rat S1121 481551 sIGGsGGsGGGGGGG DUF3498 X -Camk2a CAMK2A P11275 rat CREB iso1 81646 P15337-1 Creb1 rat S133 448228 EILsRRPsYRkILND pKID X 9187; 9196; 9198; 4095; 14228; 14001; 39561; 80120; 44864; 54960; 95995 -Camk2a CAMK2A P11275 rat APOBEC3G 60489 Q9HC16 APOBEC3G human T218 21656100 WVRGRHEtyLCYEVE NAD2 X -Camk2a CAMK2A P11275 rat NMDAR2B 24410 Q00960 Grin2b rat S1303 450171 NKLRRQHsyDtFVDL NMDAR2_C X X 20274; 71335 -Camk2a CAMK2A P11275 rat Tau iso5 4137 P10636-5 MAPT human S365 449081 GAEIVYKsPVVsGDT X 9632 -Camk2a CAMK2A P11275 rat SAPAP3 286923 P97838 Dlgap3 rat S930 481288 GVPVKERsLDsVDRQ GKAP X -Camk2a CAMK2A P11275 rat HER2 2064 P04626 ERBB2 human T1172 451643 AtLERPKtLsPGKNG X X -Camk2a CAMK2A P11275 rat MOR-1 25601 P33535 Oprm1 rat S261 447781 LMILRLKsVRMLsGS 7tm_1 X -Camk2a CAMK2A P11275 rat SHANK3 59312 Q9JLU4 Shank3 rat S1511 2048965 QLNKDTRsLGEEPVG X -Camk2a CAMK2A P11275 rat SynGAP 192117 Q9QUH6 Syngap1 rat S766 4792737 MMRDLNssIDLQSFM DUF3498 X -Camk2a CAMK2A P11275 rat mGluR1 24414 P23385 Grm1 rat T871 4713375 KLPCRSNtFLNIFRR X -Camk2a CAMK2A P11275 rat TH 7054 P07101 TH human S19 448542 KGFRRAVsELDAKQA TOH_N X -Camk2a CAMK2A P11275 rat SHANK3 59312 Q9JLU4 Shank3 rat S781 471376 KGIPRTKsVGEDEKL X X -Camk2a CAMK2A P11275 rat C/EBP-beta 1051 P17676 CEBPB human S325 11180067 EQLSRELsTLRNLFk X -Camk2a CAMK2A P11275 rat GABRB1 14400 P50571 Gabrb1 mouse S434 450244 GRIRRRAsQLKVKIP Neur_chan_memb X -Camk2a CAMK2A P11275 rat CAMK2A 25400 P11275 Camk2a rat S314 451708 MLAtRNFsGGKSGGN X -Camk2a CAMK2A P11275 rat SYN1 24949 P09951 Syn1 rat S603 450236 AGPIRQAsQAGPGPR X 88246 -Camk2a CAMK2A P11275 rat CREB iso1 81646 P15337-1 Creb1 rat S142 448547 RkILNDLssDAPGVP pKID X X -Camk2a CAMK2A P11275 rat SynGAP 192117 Q9QUH6 Syngap1 rat S780 451015 MARGLNSsMDMARLP DUF3498 X -Camk2a CAMK2A P11275 rat CAMK2A 25400 P11275 Camk2a rat T253 451571 DLINkMLtINPskRI Pkinase X -Camk2a CAMK2A P11275 rat Tau iso2 4137 P10636-2 MAPT human S307 449081 GAEIVYKsPVVSGDT X 9632 -Camk2a CAMK2A P11275 rat CAMK2B 24245 P08413 Camk2b rat S315 451707 MLAtRNFsVGRQttA X -Camk2a CAMK2A P11275 rat TH 25085 P04177 Th rat S19 448542 KGFRRAVsEQDAKQA TOH_N X -Camk2a CAMK2A P11275 rat Abi-1 11308 Q8CBW3 Abi1 mouse S88 27115701 SQLRRMEsSINHISQ X -Camk2a CAMK2A P11275 rat VAMP2 22318 P63044 Vamp2 mouse S61 451445 LERDQkLsELDDRAD Synaptobrevin X -Camk2a CAMK2A P11275 rat ASIC1 79123 P55926 Asic1 rat S477 449558 QKEAKRssADKGVAL X -Camk2a CAMK2A P11275 rat Kv4.3 65195 Q62897 Kcnd3 rat S569 455338 LPATRLRsMQELSTI X -Camk2a CAMK2A P11275 rat CAMK2A 25400 P11275 Camk2a rat T305 448802 kLkGAILttMLAtRN X -Camk2a CAMK2A P11275 rat CAMK2A 25400 P11275 Camk2a rat T306 449596 LkGAILttMLAtRNF X -Camk2a CAMK2A P11275 rat EGFR 1956 P00533 EGFR human S1071 448052 sFLQRyssDPtGALt X 2238 -Camk2a CAMK2A P11275 rat CAMK4 25050 P13234 Camk4 rat S341 2827400 RLGsASSsHTNIQES X -Camk2a CAMK2A P11275 rat DLG1 25252 Q62696 Dlg1 rat S232 451615 ITLERGNsGLGFSIA PDZ X X -Camk2a CAMK2A P11275 rat GluR KA2 24407 Q63273 Grik5 rat S859 27535800 AVSCRKTsRSRRRRR X -Camk2a CAMK2A P11275 rat CACNA1C 24239 P22002 Cacna1c rat T1603 7437803 RTALRIKtEGNLEQA Ca_chan_IQ X X -Camk2a CAMK2A P11275 rat SHANK3 59312 Q9JLU4 Shank3 rat S685 3844913 PPPKRAPsTTLTLRS X -Camk2a CAMK2A P11275 rat EGFR 1956 P00533 EGFR human S1081 452121 tGALtEDsIDDtFLP X -Camk2a CAMK2A P11275 rat Vimentin 22352 P20152 Vim mouse S39 451766 TTsTRTysLGsALRP Filament_head X 13614 -Camk2a CAMK2A P11275 rat RYR2 689560 B0LPN4 Ryr2 rat S2798 448848 yNRTRRIsQTsQVsI X -Camk2a CAMK2A P11275 rat LRRC7 117284 P70587 Lrrc7 rat T827 12157800 PLELEQstHRHtPET X -Camk2a CAMK2A P11275 rat GABRG2 14406 P22723 Gabrg2 mouse T395 452035 DIRPRsAtIQMNNAT Neur_chan_memb X -Camk2a CAMK2A P11275 rat CAMK4 25050 P13234 Camk4 rat S332 450138 AVkAVVAssRLGsAS X -Camk2a CAMK2A P11275 rat Tau iso5 4137 P10636-5 MAPT human S373 449082 PVVsGDTsPRHLSNV X 35834; 20194; 98523; 91600; 49562 -Camk2a CAMK2A P11275 rat TH 25085 P04177 Th rat S40 448545 RFIGRRQsLIEDARK TOH_N X 2791 -Camk2a CAMK2A P11275 rat TH iso2 7054 P07101-2 TH human S19 448542 KGFRRAVsELDAKQA TOH_N X -Camk2a CAMK2A P11275 rat SYN1 24949 P09951 Syn1 rat S566 456356 PQAtRQAsIsGPAPP X -Camk2a CAMK2A P11275 rat TH iso2 7054 P07101-2 TH human S67 448545 RFIGRRQsLIEDARK TOH_N X 2791 -Camk2a CAMK2A P11275 rat SHANK3 59312 Q9JLU4 Shank3 rat S694 2022961 TLTLRSKsMTAELEE X -Camk2a CAMK2A P11275 rat GluR KA2 24407 Q63273 Grik5 rat T976 27535801 PTGPRELtEHE____ X -Camk2a CAMK2A P11275 rat 14-3-3 beta 56011 P35213 Ywhab rat S60 450226 VVGARRSsWRVIsSI 14-3-3 X 52631 -Camk2a CAMK2A P11275 rat Tau iso6 4137 P10636-6 MAPT human S338 449081 GAEIVYKsPVVSGDT X 9632 -Camk2a CAMK2A P11275 rat Spinophilin 84686 O35274 Ppp1r9b rat S99 2023901 RLsLPRAssLNENVD X -Camk2a CAMK2A P11275 rat MOR-1 25601 P33535 Oprm1 rat S266 447782 LKsVRMLsGSKEKDR 7tm_1 X -Camk2a CAMK2A P11275 rat GluR KA2 24407 Q63273 Grik5 rat S892 19014315 LsNGKLysAGAGGDA X -Camk2a CAMK2A P11275 rat Tau iso6 4137 P10636-6 MAPT human S177 449080 VVRtPPKsPSSAKSR X 20473 -Camk2a CAMK2A P11275 rat TH 7054 P07101 TH human S71 448545 RFIGRRQsLIEDARK TOH_N X 2791 -Camk2a CAMK2A P11275 rat SynGAP 192117 Q9QUH6 Syngap1 rat S1073 469613 PPLQRGKsQQLTVsA DUF3498 X -Camk2a CAMK2A P11275 rat GABRB1 14400 P50571 Gabrb1 mouse S409 451812 IQyRKPLssREGFGR Neur_chan_memb X -Camk2a CAMK2A P11275 rat SynGAP 192117 Q9QUH6 Syngap1 rat S765 4792731 yMMRDLNssIDLQSF DUF3498 X -Camk2a CAMK2A P11275 rat SAPAP2 116681 P97837 Dlgap2 rat S1012 2049577 FPITREKsLDLPDRQ GKAP X -Camk2a CAMK2A P11275 rat GABRB3 14402 P63080 Gabrb3 mouse S406 486453 GIQYRKQsMPKEGHG Neur_chan_memb X -Camk2a CAMK2A P11275 rat SYN1 281510 P17599 SYN1 cow S605 450236 AGPTRQAsQAGPMPR X -Camk2a CAMK2A P11275 rat KCNMA1 282573 Q28204 KCNMA1 cow T139 469977 PVDEKEEtVAAEVGW X -Camk2a CAMK2A P11275 rat LRRC7 117284 P70587 Lrrc7 rat S826 2049457 VPLELEQstHRHtPE X -Camk2a CAMK2A P11275 rat APP 54226 P08592 App rat T729 448201 MLKKKQYtsIHHGVV APP_amyloid X -Camk2a CAMK2A P11275 rat CAMK2A 25400 P11275 Camk2a rat S279 452116 SHRSTVAsCMHRQEt X -Camk2a CAMK2A P11275 rat SYN1 20964 O88935 Syn1 mouse S605 450236 AGPtRQAsQAGPGPr X 88246 -Camk2a CAMK2A P11275 rat STMN1 29332 P13668 Stmn1 rat S16 448554 kELEKRAsGQAFELI Stathmin X 3353 -Camk2a CAMK2A P11275 rat NEUROD1 29458 Q64289 Neurod1 rat S336 451110 IPIDNIMsFDSHSHH X X -Camk2a CAMK2A P11275 rat Tau iso5 4137 P10636-5 MAPT human S235 449080 VVRtPPKsPSSAKSR X 20473 -Camk2a CAMK2A P11275 rat SAPAP1 65040 P97836 Dlgap1 rat S947 481515 APLIRERsLESSQRQ GKAP X -Camk2a CAMK2A P11275 rat ASIC1 79123 P55926 Asic1 rat S476 458230 CQKEAKRssADKGVA X -Camk2a CAMK2A P11275 rat CAMK4 25050 P13234 Camk4 rat S337 2192720 VAssRLGsASSsHTN X -Camk2a CAMK2A P11275 rat myogenin 17928 P12979 Myog mouse T87 451161 VDRRRAAtLREKRRL HLH X -Camk2a CAMK2A P11275 rat PEX5L 286937 Q925N3 Pex5l rat S237 481412 ALLsRNHsLEEEFER X -Camk2a CAMK2A P11275 rat Tau iso8 4137 P10636-8 MAPT human S235 449080 VVRtPPKsPssAKsR X 20473 -Camk2a CAMK2A P11275 rat NUMBL 292732 A1L1I3 Numbl rat S305 456489 EQLVRQGsFRGFPAL NumbF X -Camk2a CAMK2A P11275 rat TH iso3 7054 P07101-3 TH human S40 448545 RFIGRRQsLIEDARK TOH_N X 2791 -Camk2a CAMK2A P11275 rat SHANK1 78957 Q9WV48 Shank1 rat S783 12130201 RLPPPAIsLRSKSMT X -Camk2a CAMK2A P11275 rat SynGAP 192117 Q9QUH6 Syngap1 rat S1114 481549 QsLSkEGsIGGsGGs DUF3498 X -Camk2a CAMK2A P11275 rat RPT6 81827 P62198 Psmc5 rat S120 483970 RVALRNDsYTLHKIL Prot_ATP_ID_OB X -Camk2a CAMK2A P11275 rat SYT1 25716 P21707 Syt1 rat T112 448549 DVKDLGKtMKDQALK X X -CSNK2B CK2B P67870 human ATF-4 468 P18848 ATF4 human S215 27833501 IKEEDTPsDNDsGIC X -CSNK2B CK2B P67870 human TPM1 22003 P58771 Tpm1 mouse S283 451804 HALNDMtsI______ Tropomyosin X -CSNK2B CK2B P67870 human MYH9 4627 P35579 MYH9 human S1916 451181 AMNREVssLkNkLRr Myosin_tail_1 X -CSNK2B CK2B P67870 human NHE3 100009430 P26432 NHE-3 rabbit S719 3496800 KERELELsDPEEAPD X -CSNK2B CK2B P67870 human DLG3 iso2 1741 Q92796-2 DLG3 human S295 4710993 QGVTSNtsDSESSSK X -CSNK2B CK2B P67870 human SEC63 11231 Q9UGP8 SEC63 human S748 3215004 DsEGFEDsFEEEEEE X X -CSNK2B CK2B P67870 human RAD17 5884 O75943 RAD17 human S678 1184590201 IIIEDyEsDGt____ X -CSNK2B CK2B P67870 human p53 7157 P04637 TP53 human S392 447535 FktEGPDsD______ X X 9281 -CSNK2B CK2B P67870 human Snail1 6615 O95863 SNAI1 human S92 452602 VAELTsLsDEDsGkG X X -CSNK2B CK2B P67870 human SORT1 6272 Q99523 SORT1 human S825 468808 KsGyHDDsDEDLLE_ X -CSNK2B CK2B P67870 human OLIG2 50913 Q9EQW6 Olig2 mouse S13 18357900 SLVSsRPssPEPDDL X -CSNK2B CK2B P67870 human CCDC106 29903 Q9BWC9 CCDC106 human S147 1867984200 SGASEEGsASERRRQ CCDC106 X X -CSNK2B CK2B P67870 human CCDC106 29903 Q9BWC9 CCDC106 human S130 31084482 GGAGGEAsDPESAAS CCDC106 X X -CSNK2B CK2B P67870 human FADD 8772 Q13158 FADD human S200 40510683 MsPMsWNsDAsTSEA X X -CSNK2B CK2B P67870 human SEC63 11231 Q9UGP8 SEC63 human S574 27440601 EEVsDKGsDsEEEET X X -CSNK2B CK2B P67870 human SEC63 11231 Q9UGP8 SEC63 human S576 27440600 VsDKGsDsEEEETNR X X -CSNK2B CK2B P67870 human DLG3 58948 Q62936 Dlg3 rat S632 4710993 KGVTSNTsDSESSSK X -Mapk9 JNK2 P49186 rat Doublecortin iso2 1641 O43602-2 DCX human T321 451361 TSSSQLStPKSKQsP X -Mapk9 JNK2 P49186 rat Doublecortin iso2 1641 O43602-2 DCX human S334 451359 sPIStPTsPGSLRkH X 3453; 14053 -Mapk9 JNK2 P49186 rat Doublecortin iso2 1641 O43602-2 DCX human T331 469976 SKQsPIStPTsPGSL X -Mapk9 JNK2 P49186 rat CTNND2 114028 NP_001258431 Ctnnd2 rat S444 480954 RTSTAPSsPGVDSVP X -FGFR1 FGFR1 P11362 human IDH1 3417 O75874 IDH1 human Y42 3563660 VELDLHsyDLGIENR Iso_dh X -FGFR1 FGFR1 P11362 human PKM 18746 P52480 Pkm mouse Y105 450528 FAsDPILyRPVAVAL PK X X 3827 -FGFR1 FGFR1 P11362 human PDP1 54704 Q9P0J1 PDP1 human Y94 15422109 SILkANEySFkVPEF X X -FGFR1 FGFR1 P11362 human FGFR1 2260 P11362 FGFR1 human Y653 447918 RDIHHIDyykKTTNG PK_Tyr_Ser-Thr X 3471; 3476; 52928 -FGFR1 FGFR1 P11362 human FGFR1 2260 P11362 FGFR1 human Y583 448702 RRPPGLEyCyNPsHN PK_Tyr_Ser-Thr X -FGFR1 FGFR1 P11362 human AMOTL2 51421 Q9Y2J4 AMOTL2 human Y107 15561222 kGEELPTyEEAKAHS X -FGFR1 FGFR1 P11362 human ZNF198 7750 Q9UBW7 ZMYM2 human Y680 464588 KLHCIVTyCEyCQEE X -FGFR1 FGFR1 P11362 human ZNF198 7750 Q9UBW7 ZMYM2 human Y683 464589 CIVTyCEyCQEEKTL X -FGFR1 FGFR1 P11362 human FGFR1 2260 P11362 FGFR1 human Y585 448703 PPGLEyCyNPsHNPE PK_Tyr_Ser-Thr X -FGFR1 FGFR1 P11362 human ZNF198 7750 Q9UBW7 ZMYM2 human Y557 464584 QCIGPNGyMEPYCSt zf-FCS X -FGFR1 FGFR1 P11362 human NUDE1 67203 Q9CZA6 Nde1 mouse Y279 448969 ASCRNFMyDQsPsRT NUDE_C X -FGFR1 FGFR1 P11362 human PDHK1 5163 Q15118 PDK1 human Y136 11057941 AEDAkAIyDFTDTVI BCDHK_Adom3 X X -FGFR1 FGFR1 P11362 human ZNF198 7750 Q9UBW7 ZMYM2 human Y502 464583 CQSCVSEykQVGSHP zf-FCS X -FGFR1 FGFR1 P11362 human STAT3 6774 P40763 STAT3 human Y705 448192 DPGsAAPyLktKFIC X 4093; 9145; 4324; 9131; 9138; 4323; 4074; 4113; 48313; 20977; 25023; 8119; 52075; 52527; 73533; 61958; 73452; 16185; 74309 -FGFR1 FGFR1 P11362 human NUDE1 67203 Q9CZA6 Nde1 mouse Y90 912008302 EMQHSEGyRQISALE X -FGFR1 FGFR1 P11362 human LDH-A 3939 P00338 LDHA human Y83 3780568 kIVSGkDyNVTANsk Ldh_1_N X -FGFR1 FGFR1 P11362 human PDHK1 5163 Q15118 PDK1 human Y244 465268 RRLCDLyyINSPELE X X -FGFR1 FGFR1 P11362 human FGFR1 2260 P11362 FGFR1 human Y730 448642 SNCTNELyMMMRDCW PK_Tyr_Ser-Thr X -FGFR1 FGFR1 P11362 human ZDHHC3 69035 Q8R173 Zdhhc3 mouse Y18 462842 DIERKPEyLQPEKCA X -FGFR1 FGFR1 P11362 human ZNF198 7750 Q9UBW7 ZMYM2 human Y729 464590 LRCVTCNyCSQLCKk zf-FCS X -FGFR1 FGFR1 P11362 human FGFR1 2260 P11362 FGFR1 human Y654 447919 DIHHIDyykKTTNGR PK_Tyr_Ser-Thr X 3471; 3476; 52928 -FGFR1 FGFR1 P11362 human ITGB4 3691 P16144 ITGB4 human Y1564 456323 LQGYSVEyQLLNGGE fn3 X -FGFR1 FGFR1 P11362 human NLGN1 192167 Q99K10 Nlgn1 mouse Y782 1008111 RTACPPDyTLAMRRS X -FGFR1 FGFR1 P11362 human ZNF198 7750 Q9UBW7 ZMYM2 human Y595 464585 KRNsLPQyQATMPDG X -FGFR1 FGFR1 P11362 human FGFR1 2260 P11362 FGFR1 human Y154 448774 NRMPVAPyWTSPEKM X -FGFR1 FGFR1 P11362 human FGFR1 2260 P11362 FGFR1 human Y766 447922 ALTSNQEyLDLSMPL X 2544; 84309 -FGFR1 FGFR1 P11362 human FGFR1 2260 P11362 FGFR1 human Y463 448641 MLAGVSEyELPEDPR X -FGFR1 FGFR1 P11362 human PDP1 54704 Q9P0J1 PDP1 human Y381 15422118 DQLNDNEyTkFIPPN PP2C X -FGFR1 FGFR1 P11362 human PLCG1 5335 P19174 PLCG1 human Y783 447667 EGRNPGFyVEANPMP X 2821; 14461; 14008; 25678; 88717 -FGFR1 FGFR1 P11362 human LDH-A 3939 P00338 LDHA human Y10 454712 tLkDQLIyNLLkEEQ X X -FGFR1 FGFR1 P11362 human PDHA1 5160 P08559 PDHA1 human Y301 454753 MsDPGVsyRtREEIQ E1_dh X -FGFR1 FGFR1 P11362 human PDHK1 5163 Q15118 PDK1 human Y243 462384 ARRLCDLyyINSPEL X X -FGFR1 FGFR1 P11362 human ACAT1 38 P24752 ACAT1 human Y407 10943316 HALKQGEyGLASICN Thiolase_C X -FGFR1 FGFR1 P11362 human ZNF198 7750 Q9UBW7 ZMYM2 human Y605 464586 TMPDGkLyNFCNsSC X -ERN1 IRE1 O75460 human IRE1 2081 O75460 ERN1 human Y628 41192601 EHPNVIRyFCTEkDR Pkinase X -GRK3 GRK3 P35626 human KOR-3 4987 P41146 OPRL1 human S346 1868135700 LRRDVQVsDRVRsIA X -GRK3 GRK3 P35626 human KOR-1 18387 P33534 Oprk1 mouse S369 449609 NtVQDPAsMRDVGGM X X -GRK3 GRK3 P35626 human CCR5 1234 P51681 CCR5 human S337 448725 EAPERAssVyTRstG X -GRK3 GRK3 P35626 human SSTR2 P30680 Sstr2 rat T353 7652102 DKsRLNEttEtQRtL X -GRK3 GRK3 P35626 human SSTR2 6752 P30874 SSTR2 human S341 7652103 GTDDGERsDsKQDKS X -GRK3 GRK3 P35626 human MOR-1 18390 P42866 Oprm1 mouse T376 20727901 NtREHPstANtVDRT X -GRK3 GRK3 P35626 human KOR-3 4987 P41146 OPRL1 human S351 1868135701 QVsDRVRsIAKDVAL X -GRK3 GRK3 P35626 human DOR-1 4985 P41143 OPRD1 human T361 448551 RERVtACtPsDGPGG X -GRK3 GRK3 P35626 human CXCR4 12767 P70658 Cxcr4 mouse S354 12575201 VsTESEsssFHSs__ X -GRK3 GRK3 P35626 human SSTR2 P30680 Sstr2 rat T359 12577700 EttEtQRtLLNGDLQ X -GRK3 GRK3 P35626 human TXA2-R iso2 6915 P21731-2 TBXA2R human S357 469629 RLPGSSDsRASASRA X -GRK3 GRK3 P35626 human DOR-1 4985 P41143 OPRD1 human S363 448550 RVtACtPsDGPGGGA X -GRK3 GRK3 P35626 human ADRB2 154 P07550 ADRB2 human S355 458916 KAyGNGyssNGNtGE X X -GRK3 GRK3 P35626 human TXA2-R iso2 6915 P21731-2 TBXA2R human S239 469628 AQQRPRDsEVEMMAQ 7tm_1 X -GRK3 GRK3 P35626 human KOR-3 4987 P41146 OPRL1 human S363 27150200 VALACKtsETVPRPA X -GRK3 GRK3 P35626 human CCR5 1234 P51681 CCR5 human S342 449902 AssVyTRstGEQEIs X -GRK3 GRK3 P35626 human SSTR2 P30680 Sstr2 rat T356 12577701 RLNEttEtQRtLLNG X -GRK3 GRK3 P35626 human SSTR2 P30680 Sstr2 rat T354 7652101 KsRLNEttEtQRtLL X -GRK3 GRK3 P35626 human MOR-1 18390 P42866 Oprm1 mouse T370 447785 sARIRQNtREHPstA X -GRK3 GRK3 P35626 human MOR-1 18390 P42866 Oprm1 mouse S375 447784 QNtREHPstANtVDR X 3451 -GRK3 GRK3 P35626 human ADRB2 154 P07550 ADRB2 human S356 458917 AyGNGyssNGNtGEQ X X -GRK3 GRK3 P35626 human CCR5 1234 P51681 CCR5 human S336 449901 QEAPERAssVyTRst X -GRK3 GRK3 P35626 human SSTR2 6752 P30874 SSTR2 human S343 7652105 DDGERsDsKQDKSRL X -GRK3 GRK3 P35626 human CCR5 1234 P51681 CCR5 human S349 448724 stGEQEIsVGL____ X -GRK3 GRK3 P35626 human CXCR4 12767 P70658 Cxcr4 mouse S353 7997136 sVsTESEsssFHSs_ X -GRK3 GRK3 P35626 human KOR-3 4987 P41146 OPRL1 human T362 1868135702 DVALACKtsETVPRP X -GRK3 GRK3 P35626 human MOR-1 18390 P42866 Oprm1 mouse T379 20727900 EHPstANtVDRTNHQ X -SGK3 SGK3 Q96BR1 human ITCH 83737 Q96J02 ITCH human S450 470110 GWEkRTDsNGRVYFV WW X -SGK3 SGK3 Q96BR1 human L-plastin 3936 P13796 LCP1 human S5 450852 ___MARGsVsDEEMM X X -SGK3 SGK3 Q96BR1 human ITCH 83737 Q96J02 ITCH human T385 26342102 DHFTRTTtWQRPTLE WW X -SGK3 SGK3 Q96BR1 human WDR44 54521 Q5JSH3 WDR44 human S344 480095 PQRPRsNsGRELtDE X -SGK3 SGK3 Q96BR1 human FLI 2314 Q13045 FLII human S436 470489 RLRRRKDsAQDDQAK X X -SGK3 SGK3 Q96BR1 human FLI 2314 Q13045 FLII human T818 25787600 LHRPRHAtVSRsLEG Gelsolin X -SGK3 SGK3 Q96BR1 human GSK3B 2932 P49841 GSK3B human S9 449111 SGRPRttsFAEsCkP X X 9336; 9331; 9327; 9323; 9322; 9325; 5558; 8566; 79774; 8466; 25462; 14026; 14332; 14310; 14630 -SGK3 SGK3 Q96BR1 human MDM2 4193 Q00987 MDM2 human S166 448130 SsRRRAIsEtEENsD X 3521 -SGK3 SGK3 Q96BR1 human HSD17B4 3295 P51659 HSD17B4 human S318 7445507 NHtSRAtstATsGFA X -ATM ATM Q13315 human FANCI 55215 Q9NVI1 FANCI human S972 11952933 SLLNLLSsQEEDFNS FANCI_S3 X -ATM ATM Q13315 human KHDC3L 154288 Q587J8 KHDC3L human T145 1673970100 IEVREAGtQRSVEVR X -ATM ATM Q13315 human MCM3 17215 P25206 Mcm3 mouse S732 475062 sQEKtDDsQEtQDsQ X -ATM ATM Q13315 human NKX3-1 4824 Q99801 NKX3-1 human T166 28750702 kNLkLTEtQVKIWFQ Homeodomain X -ATM ATM Q13315 human 53BP1 7158 Q12888 TP53BP1 human S29 450162 IEDsQPEsQVLEDDS X 2674 -ATM ATM Q13315 human KHSRP 8570 Q92945 KHSRP human S670 482098 GPGAPPGsQPDySAA DUF1897 X X -ATM ATM Q13315 human Artemis 64421 Q96SD1 DCLRE1C human S503 466574 NDEITDEsLENFPSS X -ATM ATM Q13315 human RRM2B 50484 Q7LG56 RRM2B human S72 5014902 TAEEVDLsKDLPHWN Ribonuc_red_sm X X -ATM ATM Q13315 human DBN1 iso3 1627 Q16643-3 DBN1 human S647 472365 SEGYFSQsQEEEFAQ X X -ATM ATM Q13315 human KHDC3L 154288 Q587J8 KHDC3L human T156 25285513 VEVREAGtQRSVEVQ X -ATM ATM Q13315 human CROCC iso2 9696 Q5TZA2-2 CROCC human S922 481961 TESELRAsQEKISKM X X -ATM ATM Q13315 human FANCD2 2177 Q9BXW9 FANCD2 human S222 447816 LPEILGDsQHADVGK FancD2 X X -ATM ATM Q13315 human FBXW7 55294 Q969H0 FBXW7 human S26 482101 LRGNPSssQVDEEQM X -ATM ATM Q13315 human RAP80 51720 Q96RL1 UIMC1 human S205 486299 sGsWDQSsQPVFENV X -ATM ATM Q13315 human WAPL 23063 Q7Z5K2 WAPL human S498 1880758402 PPESNDNsQDSQSGT X -ATM ATM Q13315 human E2F1 1869 Q01094 E2F1 human S31 447867 ALRLLDSsQIVIISA X X -ATM ATM Q13315 human MDM2 4193 Q00987 MDM2 human S407 450263 SSSIIyssQEDVKEF X -ATM ATM Q13315 human p53 7157 P04637 TP53 human S37 447532 NVLsPLPsQAMDDLM TAD2 X 9289 -ATM ATM Q13315 human Chk2 11200 O96017 CHEK2 human S33 447549 tQsQGSSsQsQGIss X 2665 -ATM ATM Q13315 human SLX4 84464 Q8IY92 SLX4 human S1631 11952923 PHCQTLAsQTYKPSR X -ATM ATM Q13315 human NFAT5 10725 O94916 NFAT5 human S1247 452031 AMQSNSPsQEQQQQQ X -ATM ATM Q13315 human TRIM24 8805 O15164 TRIM24 human S217 1880463700 PEAVGVTsQRPVFCP X -ATM ATM Q13315 human POLL 27343 Q9UGP5 POLL human T204 62925702 EASDGEEtQVSAADL X -ATM ATM Q13315 human PTEN 5728 P60484 PTEN human T398 4695758 PFDEDQHtQItkV__ X -ATM ATM Q13315 human XPA 7507 P23025 XPA human S196 460698 RSLEVWGsQEALEEA X -ATM ATM Q13315 human hnRNP P2 2521 P35637 FUS human S42 3306333 QQSYSGYsQSTDTSG X -ATM ATM Q13315 human MDM2 4193 Q00987 MDM2 human S386 11956709 DDKITQAsQsQESED X X -ATM ATM Q13315 human USP2 9099 O75604 USP2 human S2 1880716202 ______MsQLSSTLK X -ATM ATM Q13315 human HUWE1 10075 Q7Z6Z7 HUWE1 human S3797 482007 QAAtsESsQSEAsVR X -ATM ATM Q13315 human SP1 6667 P08047 SP1 human S101 767911 DLTATQLsQGANGWQ X X -ATM ATM Q13315 human NRF1 4899 Q16656 NRF1 human T259 23255803 QKQRVSWtQALRTIV Nrf1_DNA-bind X -ATM ATM Q13315 human MED1 5469 Q15648 MED1 human S872 11952939 FNPDLLNsQsQSGFG X -ATM ATM Q13315 human RAGE 11596 Q62151 Ager mouse S376 4731271 EERKAPEsQEDEEER X X -ATM ATM Q13315 human HSP90A 3320 P07900 HSP90AA1 human T7 448320 _MPEEtQtQDQPMEE X 3488 -ATM ATM Q13315 human SMC3 9126 Q9UQE7 SMC3 human S1067 453059 GDVEGsQsQDEGEGs SMC_N X -ATM ATM Q13315 human OBFC2B 79035 Q9BQ15 NABP2 human T117 12526701 EPNPEYstQQAPNKA X -ATM ATM Q13315 human TET1 80312 Q8NFU7 TET1 human S1976 1881549504 PPsDEPLsDDPLSPA X X -ATM ATM Q13315 human YAP1 10413 P46937 YAP1 human Y391 15565111 PFLNsGtyHSRDEst X -ATM ATM Q13315 human MCPH1 79648 Q8NEM0 MCPH1 human S322 36125335 QKQAAGMsQETFEEk Microcephalin X -ATM ATM Q13315 human DTYMK 1841 P23919 DTYMK human S88 1253766700 PLIkEKLsQGVtLVV Thymidylate_kin X -ATM ATM Q13315 human RNF40 9810 O75150 RNF40 human S853 11952910 EkELTLRsQALELNK X -ATM ATM Q13315 human TOP2B iso2 7155 Q02880-2 TOP2B human S1134 34733062 SSDsGTPsGPDFNYI DNA_topoisoIV X -ATM ATM Q13315 human PPM1G 5496 O15355 PPM1G human S183 460849 GTGEEPGsQGLNGEA X X -ATM ATM Q13315 human AVEN 57099 Q9NQS1 AVEN human S308 4859800 NILPDQTsQDLKSKE X -ATM ATM Q13315 human MEN1 iso1 4221 O00255-1 MEN1 human S399 477697 EERPGEQsQGTQSQG Menin X -ATM ATM Q13315 human 53BP1 7158 Q12888 TP53BP1 human S1778 458312 FNkQYTEsQLRAGAG X 2675 -ATM ATM Q13315 human HUWE1 10075 Q7Z6Z7 HUWE1 human S3377 1249861 kACsPCSsQSSSSGI X -ATM ATM Q13315 human RFA2 6118 P15927 RPA2 human S29 448338 QsPGGFGsPAPsQAE X -ATM ATM Q13315 human DBF4 10926 Q9UBU7 DBF4 human S502 23010417 FSTDNSGsQPKQKsD X X -ATM ATM Q13315 human PPP1R2 5504 P41236 PPP1R2 human S44 2231000 DEELSKKsQKWDEMN X X -ATM ATM Q13315 human 4E-BP1 116636 Q62622 Eif4ebp1 rat S111 447526 KRAGGEEsQFEMDI_ eIF_4EBP X X -ATM ATM Q13315 human Artemis 64421 Q96SD1 DCLRE1C human S649 38410201 NADsQsssDFEVPst X -ATM ATM Q13315 human CBL 867 P22681 CBL human S866 1868914506 SEIENLMsQGYSYQD UBA X X -ATM ATM Q13315 human Chk2 11200 O96017 CHEK2 human S28 447548 PHGsVtQsQGSSsQs X -ATM ATM Q13315 human PRPF19 27339 Q9UMS4 PRPF19 human S149 25247501 VPQAVPSsQPSVVGA X -ATM ATM Q13315 human MAD1L1 8379 Q9Y6D9 MAD1L1 human S214 482335 kIQELQAsQEARADH MAD X X -ATM ATM Q13315 human UCHL3 7347 P15374 UCHL3 human S75 482705 EEEEKIKsQGQDVTS Peptidase_C12 X X -ATM ATM Q13315 human RANBP9 10048 Q96S59 RANBP9 human S550 54363507 NSINMSRsQQVNNFT CTLH X -ATM ATM Q13315 human SMC3 9126 Q9UQE7 SMC3 human S1083 453061 EsErGsGsQssVPSV SMC_N X X -ATM ATM Q13315 human ATM 472 Q13315 ATM human S367 467198 DTRSLEIsQSyTttQ X X -ATM ATM Q13315 human Pnk1 11284 Q96T60 PNKP human S114 460832 EEtRtPEsQPDtPPG X X 3522 -ATM ATM Q13315 human TAO1 57551 Q7L7X3 TAOK1 human T643 3627518 EELNKRQtQKDLEHA X -ATM ATM Q13315 human CtIP 5932 Q99708 RBBP8 human S664 448391 IDPGADLsQYKMDVT X -ATM ATM Q13315 human p53 7157 P04637 TP53 human S46 447536 AMDDLMLsPDDIEQW TAD2 X X 2521 -ATM ATM Q13315 human TOPBP1 11073 Q92547 TOPBP1 human S853 4742692 LEtPGRPsQQkRKPs X -ATM ATM Q13315 human NIPBL 25836 Q6KC79 NIPBL human S563 1880758400 sItQDSDsIKKPEEI X -ATM ATM Q13315 human TAO1 57551 Q7L7X3 TAOK1 human S990 3627517 SrSTsVTsQIsNGSH X -ATM ATM Q13315 human FANCI 55215 Q9NVI1 FANCI human S1121 482144 TLSEEAssQATLPNQ FANCI_S4 X -ATM ATM Q13315 human FANCD2 2177 Q9BXW9 FANCD2 human S717 453231 KDGGPVTsQESGQkL FancD2 X -ATM ATM Q13315 human AVEN 57099 Q9NQS1 AVEN human S135 4859801 VNNESGEsQRGTDFS X -ATM ATM Q13315 human HUWE1 10075 Q7Z6Z7 HUWE1 human S927 11952913 ISVNQWGsQLGLSVL X -ATM ATM Q13315 human MRE11A 4361 P49959 MRE11 human S678 460789 sskIMsQsQVsKGVD X X -ATM ATM Q13315 human TCF8 6935 P37275 ZEB1 human S585 36552500 GDGNLsPsQPPLKNL X X -ATM ATM Q13315 human MCM3 17215 P25206 Mcm3 mouse S725 475061 HtPKtDDsQEKtDDs X -ATM ATM Q13315 human FANCI 55215 Q9NVI1 FANCI human S730 482143 LDksADFsQsTSIGI FANCI_HD2 X -ATM ATM Q13315 human HUWE1 10075 Q7Z6Z7 HUWE1 human S2339 11952914 GQPEVLSsQEMQVEN X -ATM ATM Q13315 human ATM 472 Q13315 ATM human T1885 4731752 sQTSRsTtPANLDsE X -ATM ATM Q13315 human MED1 5469 Q15648 MED1 human S1141 11952942 sQGSSGSsQSKNSsQ X -ATM ATM Q13315 human FANCD2 2177 Q9BXW9 FANCD2 human T691 470035 yGLEEYDtQDGIAIN FancD2 X -ATM ATM Q13315 human L3MBTL2 83746 Q969R5 L3MBTL2 human S335 1046182902 RLEVVDKsQVsRTRM MBT X -ATM ATM Q13315 human APLF 200558 Q8IW19 APLF human S116 482841 MQCTLRNsQVLDEDN X -ATM ATM Q13315 human FBXL11 22992 Q9Y2K7 KDM2A human T632 482318 EVDQNEEtQDFEKKL PHD_4 X X -ATM ATM Q13315 human ID3 3399 Q02535 ID3 human S65 297110002 VPRGTQLsQVEILQR HLH X -ATM ATM Q13315 human ATM 472 Q13315 ATM human S2996 7433302 QECkRNLsDIDQSFN X X -ATM ATM Q13315 human BAT3 7917 P46379 BAG6 human S26 11952932 VLVktLDsQTRTFIV ubiquitin X -ATM ATM Q13315 human Smc1 8243 Q14683 SMC1A human S957 448697 IsQEEGssQGEDsVs SMC_N X X 4805; 58052 -ATM ATM Q13315 human Artemis 64421 Q96SD1 DCLRE1C human T656 38410200 sDFEVPstPEAELPK X -ATM ATM Q13315 human BRCA1 672 P38398 BRCA1 human S1524 448038 LQNRNYPsQEELIKV X X 9009 -ATM ATM Q13315 human TRF1 7013 P54274 TERF1 human S367 22996308 SRIPVSKsQPVtPEK X X -ATM ATM Q13315 human RAGE 11596 Q62151 Ager mouse S389 4731275 ERAELNQsEEAEMPE X X -ATM ATM Q13315 human GIT2 9815 Q14161 GIT2 human S384 30999681 NNQHsVEsQDNDQPd X -ATM ATM Q13315 human SCC-112 23244 Q29RF7 PDS5A human S1278 3965429 GRRPKsEsQGNATKN X -ATM ATM Q13315 human DCK 13178 P43346 Dck mouse S74 456305 EFEELTtsQKSGGNV dNK X X -ATM ATM Q13315 human BRCA1 672 P38398 BRCA1 human S1387 455495 EDCSGLSsQSDILTt X X -ATM ATM Q13315 human ATM 472 Q13315 ATM human S1893 467199 PANLDsEsEHFFRCC X X -ATM ATM Q13315 human COPS5 10987 Q92905 COPS5 human S320 33365506 EAIHGLMsQVIkDkL CSN5_C X X -ATM ATM Q13315 human RNF138 51444 Q8WVD3 RNF138 human S124 472443 IIPNFQIsQDsVGNS X -ATM ATM Q13315 human SLX4 84464 Q8IY92 SLX4 human S1271 11952922 sRSRDCSsQtQISSL X -ATM ATM Q13315 human ATF-2 1386 P15336 ATF2 human S490 455782 QSTEPALsQIVMAPS X -ATM ATM Q13315 human MDC1 9656 Q14676 MDC1 human T4 3965656 ____MEDtQAIDWDV X X -ATM ATM Q13315 human HIF1A 3091 Q16665 HIF1A human S696 17595900 NVLsVALsQRTtVPE X X -ATM ATM Q13315 human BLM 641 P54132 BLM human T99 450958 NAPAGQEtQRGGSkS BLM_N X X -ATM ATM Q13315 human USP28 57646 Q96RU2 USP28 human S720 11952928 SsQDYSTsQEPSVAS X -ATM ATM Q13315 human USP10 9100 Q14694 USP10 human T42 12483201 SGTVLCGtQAVDKLP X -ATM ATM Q13315 human Artemis 64421 Q96SD1 DCLRE1C human S645 457531 NLSTNADsQsssDFE X X -ATM ATM Q13315 human CREB 1385 P16220 CREB1 human S107 451811 sVDsVtDsQKRREIL pKID X X -ATM ATM Q13315 human EZH2 iso2 2146 Q15910-2 EZH2 human S734 29606713 LFFDYRYsQADALKY X X -ATM ATM Q13315 human UBR5 51366 O95071 UBR5 human S1532 11952918 SDQSSSSsQSQSSYI X -ATM ATM Q13315 human USP34 9736 Q70CQ2 USP34 human S718 11952930 ATHIAQGsQESCITR X -ATM ATM Q13315 human MDM2 4193 Q00987 MDM2 human S425 11956708 EtQDKEEsVESsLPL X -ATM ATM Q13315 human Smc1 8243 Q14683 SMC1A human S360 452414 RMEEEsQsQGRDLtL SMC_N X 4029 -ATM ATM Q13315 human KHDRBS1 10657 Q07666 KHDRBS1 human T61 3194543 GARAsPAtQPPPLLP X -ATM ATM Q13315 human HUWE1 10075 Q7Z6Z7 HUWE1 human S2636 4955267 HDQsTAtsQAGTLSS X -ATM ATM Q13315 human ATF-2 1386 P15336 ATF2 human S498 455783 QIVMAPSsQSQPSGS X -ATM ATM Q13315 human WAPL 23063 Q7Z5K2 WAPL human S305 22780675 RANKTkssQGASNFD X -ATM ATM Q13315 human DDX1 1653 Q92499 DDX1 human S671 36406800 EHLNCTIsQVEPDIK X X -ATM ATM Q13315 human p53 7157 P04637 TP53 human S33 447531 LPENNVLsPLPsQAM X 2526 -ATM ATM Q13315 human CtIP 225182 Q80YR6 Rbbp8 mouse T843 7113805 FRYIPPNtPENFWEV SAE2 X -ATM ATM Q13315 human TRF1 7013 P54274 TERF1 human S219 448475 SKLLMIIsQKDTFHS TRF X X -ATM ATM Q13315 human HNF1A 6927 P20823 HNF1A human S249 451310 IQRGVsPsQAQGLGS X X -ATM ATM Q13315 human ATM 472 Q13315 ATM human S440 486365 SPLLMILsQLLPQQR X -ATM ATM Q13315 human MDC1 9656 Q14676 MDC1 human T98 20583303 DCGsLNGtQILRPPK FHA X X -ATM ATM Q13315 human PPP2R5C 5527 Q13362 PPP2R5C human S520 18958501 CRADELAsQDGR___ X X -ATM ATM Q13315 human p63 22061 O88898 Tp63 mouse S41 27937106 SYYRSAMsQSTQTSE X -ATM ATM Q13315 human RIF1 55183 Q5UIP0 RIF1 human S1851 481963 sEAMsLEsQEsPNEN X -ATM ATM Q13315 human ATM 300711 D4ACL8 Atm rat S1988 448797 sPTFEEGsQGTTISS X -ATM ATM Q13315 human beclin 1 8678 Q14457 BECN1 human T57 4275031 AQAkPGEtQEEETNs X X -ATM ATM Q13315 human DYRK2 8445 Q92630 DYRK2 human T106 11489910 NKRTVLTtQPNGLTT X -ATM ATM Q13315 human MDM2 4193 Q00987 MDM2 human S395 447898 sQESEDysQPSTSSS X X -ATM ATM Q13315 human Smc1 8243 Q14683 SMC1A human S358 481894 EERMEEEsQsQGRDL SMC_N X -ATM ATM Q13315 human BRCA1 672 P38398 BRCA1 human S1423 448036 AVLEQHGsQPSNSYP X X -ATM ATM Q13315 human AATF 26574 Q9NY61 AATF human S189 3753300 EGDDAEDsQGEsEED X -ATM ATM Q13315 human MLLT1 4298 Q03111 MLLT1 human S398 40666502 FEPsQNHsQGPLRsM X -ATM ATM Q13315 human SMURF2 64750 Q9HAU4 SMURF2 human S384 1870790704 kILRQELsQQQPQAG X -ATM ATM Q13315 human Smc1 8243 Q14683 SMC1A human S966 448698 GEDsVsGsQRIssIy SMC_N X X -ATM ATM Q13315 human PELP1 27043 Q8IZL8 PELP1 human S1033 472322 LAPEALPsQGEVERE X -ATM ATM Q13315 human RAD17 5884 O75943 RAD17 human S646 447755 ETWSLPLsQNSASEL X X 13404 -ATM ATM Q13315 human PIDD 55367 Q9HB75 PIDD1 human T788 25680403 DAETGFLtQSNLLSV X X -ATM ATM Q13315 human Chk1 1111 O14757 CHEK1 human S345 447834 LVQGIsFsQPtCPDH X 2341; 2348; 12268; 76784 -ATM ATM Q13315 human 53BP1 7158 Q12888 TP53BP1 human S1219 481849 DDtEsLHsQGEEEFD X X -ATM ATM Q13315 human NIPBL 25836 Q6KC79 NIPBL human S553 1249849 HQAGRVDsQAsItQD X -ATM ATM Q13315 human TOPBP1 11073 Q92547 TOPBP1 human S554 11379601 ITEEGLFsQKSFLVL X -ATM ATM Q13315 human MED1 5469 Q15648 MED1 human S887 11952940 EEYFDESsQSGDNDD X -ATM ATM Q13315 human 53BP1 7158 Q12888 TP53BP1 human S25 450163 PCLIIEDsQPEsQVL X 2674 -ATM ATM Q13315 human SLX4 84464 Q8IY92 SLX4 human S1138 11952925 PDHsSSRsQKSSSKL X -ATM ATM Q13315 human CCDC6 8030 Q16204 CCDC6 human T434 479429 tPPPSPNtQTPVQPP X -ATM ATM Q13315 human RAGE 177 Q15109 AGER human S391 4731275 ERAELNQsEEPEAGE X -ATM ATM Q13315 human BAT3 7917 P46379 BAG6 human S218 11952931 PEPVALSsQTSEPVE X -ATM ATM Q13315 human MED1 5469 Q15648 MED1 human S1134 477909 LsSSMyssQGSSGSs X -ATM ATM Q13315 human TDP1 55775 Q9NUW8 TDP1 human S563 460794 KQKFFAGsQEPMATF Tyr-DNA_phospho X -ATM ATM Q13315 human BRCA1 672 P38398 BRCA1 human S1497 448730 EPGVERssPsKCPsL X -ATM ATM Q13315 human BUB1 699 O43683 BUB1 human S314 481705 sHEDLPAsQERSEVN X X -ATM ATM Q13315 human BRCA1 672 P38398 BRCA1 human S1189 450007 QKGELsRsPsPFtHT X -ATM ATM Q13315 human SARS 6301 P49591 SARS1 human S241 482693 MQEVAQLsQFDEELy X X -ATM ATM Q13315 human Fe65 322 O00213 APBB1 human S228 36841900 DSSWATLsQGSPSYG X -ATM ATM Q13315 human HIC1 3090 Q14526 HIC1 human S713 1872610000 DKAAEVLsQGAHLAA X -ATM ATM Q13315 human SMC3 9126 Q9UQE7 SMC3 human S383 1880758200 YAkQGRGsQFTsKEE X -ATM ATM Q13315 human DGCR8 54487 Q8WYQ5 DGCR8 human S677 1874101914 RVGKQLAsQKILQLL dsrm X X -ATM ATM Q13315 human SMARCC2 6601 Q8TAQ2 SMARCC2 human S969 15707400 PPALPPGsQPIPPTG X -ATM ATM Q13315 human USP10 9100 Q14694 USP10 human S337 12483200 ASGTLPVsQPKsWAS X -ATM ATM Q13315 human DNAPK 5591 P78527 PRKDC human T2638 448712 VAGQIRAtQQQHDFt DNAPKcs_CC5 X -ATM ATM Q13315 human UFL1 23376 O94874 UFL1 human S462 15436603 DDDsDDEsQssHtGK X -ATM ATM Q13315 human Artemis 64421 Q96SD1 DCLRE1C human S648 38410203 TNADsQsssDFEVPs X -ATM ATM Q13315 human SMAD1 4086 Q15797 SMAD1 human S239 25546600 DPMTQDGsQPMDTNM X X -ATM ATM Q13315 human VCP 7415 P55072 VCP human S326 3850834 EVERRIVsQLLtLMD AAA X -ATM ATM Q13315 human MCM3 4172 P25205 MCM3 human S535 475983 ATDDPNFsQEDQQDT X X -ATM ATM Q13315 human CBL 867 P22681 CBL human T640 23090718 DVPRLGstFsLDtsM X X -ATM ATM Q13315 human NBS1 4683 O60934 NBN human S343 448605 TtPGPsLsQGVsVDE X X 3001 -ATM ATM Q13315 human DNAPK 5591 P78527 PRKDC human T2609 448710 LtPMFVEtQAsQGtL DNAPKcs_CC5 X -ATM ATM Q13315 human SP1 6667 P08047 SP1 human S56 767910 tGGGGQEsQPsPLAL X -ATM ATM Q13315 human UBR5 51366 O95071 UBR5 human S191 11952917 VIPEELIsQAQVVLQ E3_UbLigase_EDD X -ATM ATM Q13315 human RANBP9 10048 Q96S59 RANBP9 human S603 482142 tEMEVDSsQLRRQLC CTLH X X -ATM ATM Q13315 human TOPBP1 11073 Q92547 TOPBP1 human T1062 460941 NDSkGVLtQtLEMRE X -ATM ATM Q13315 human SARS 6301 P49591 SARS1 human S101 23141783 ALANLkVsQIKKVRL Seryl_tRNA_N X X -ATM ATM Q13315 human NFAT5 10725 O94916 NFAT5 human S1197 452030 HIQTPMLsQEQAQPP X -ATM ATM Q13315 human Ku70 2547 P12956 XRCC6 human S27 449267 QEENLEAsGDykYsG X -ATM ATM Q13315 human TAO3 51347 Q9H2K8 TAOK3 human S359 468905 SMSVSTGsQSSSVNS X -ATM ATM Q13315 human USP28 57646 Q96RU2 USP28 human S495 11952927 STSTEsSsQDVESTF UCH X -ATM ATM Q13315 human BTRC 8945 Q9Y297 BTRC human S158 1872610002 EFVEHLIsQMCHYQH Beta-TrCP_D X -ATM ATM Q13315 human ITCH iso2 83737 Q96J02-2 ITCH human S161 33522000 TTCSESAsQNDDGSR X -ATM ATM Q13315 human METTL3 56339 Q86U44 METTL3 human S43 483736 rNPEAALsPTFRsDs X X -ATM ATM Q13315 human BANP 53325 Q8VBU8 Banp mouse S370 36440208 PTSELQQsQPQALHY X X -ATM ATM Q13315 human C1QBP 12261 O35658 C1qbp mouse S147 1783001 FDGEEEPsQGQKAEE MAM33 X -ATM ATM Q13315 human RFWD3 55159 Q6PCD5 RFWD3 human S63 11952912 APAEVISsQATPPLL X -ATM ATM Q13315 human ZNF148 7707 Q9UQR1 ZNF148 human S202 483978 GEkPFQCsQCDMRFI zf-C2H2 X X -ATM ATM Q13315 human Pnk1 11284 Q96T60 PNKP human S126 460833 PPGtPLVsQDEKRDA X X -ATM ATM Q13315 human RAP80 20184 Q5U5Q9 Uimc1 mouse S205 486299 SGSWDQSsQPVFENE X -ATM ATM Q13315 human RAD17 5884 O75943 RAD17 human T633 31894301 EESLGEPtQATVPET X X -ATM ATM Q13315 human RASSF1 11186 Q9NS23 RASSF1 human S135 486364 EWETPDLsQAEIEQk X X -ATM ATM Q13315 human NKX3-1 4824 Q99801 NKX3-1 human T134 28750701 SRAAFSHtQVIELER Homeodomain X -ATM ATM Q13315 human Abraxas 84142 Q6UWZ7 ABRAXAS1 human S406 3203163 GFGEYsRsPtF____ X -ATM ATM Q13315 human Artemis 64421 Q96SD1 DCLRE1C human S516 460660 SSTVAGGsQsPKLFS X X -ATM ATM Q13315 human CREB 1385 P16220 CREB1 human S119 448228 EILsRRPsyRkILND pKID X X 9187; 9196; 9198; 4095; 14228; 14001; 39561; 80120; 44864; 54960; 95995 -ATM ATM Q13315 human KHDRBS1 10657 Q07666 KHDRBS1 human S388 5832066 EGYEGYysQsQGDSE Sam68-YY X -ATM ATM Q13315 human SMC3 9126 Q9UQE7 SMC3 human S1065 453058 KkGDVEGsQsQDEGE SMC_N X -ATM ATM Q13315 human TAO3 51347 Q9H2K8 TAOK3 human S551 11952936 DLTTFLEsQKKQYKI X -ATM ATM Q13315 human UBR5 51366 O95071 UBR5 human S174 11952916 rGsGLLGsQPQPVIP X -ATM ATM Q13315 human SRPK1 6732 Q96SB4 SRPK1 human S408 1872827400 QNGDSSTsQETDSCT X -ATM ATM Q13315 human CREB iso1 1385 P16220-1 CREB1 human T100 457131 LKRLFsGtQISTIAE X -ATM ATM Q13315 human p27Kip1 1027 P46527 CDKN1B human S140 481797 PkTDPSDsQTGLAEQ X X -ATM ATM Q13315 human MED1 5469 Q15648 MED1 human S816 11952938 DSSSSGHsQSTLFDS X -ATM ATM Q13315 human CREB 1385 P16220 CREB1 human S97 451808 TIAEsEDsQEsVDsV X -ATM ATM Q13315 human BRCA1 672 P38398 BRCA1 human S1457 450008 SEKAVLTsQKsSEYP X X -ATM ATM Q13315 human EHMT2 10919 Q96KQ7 EHMT2 human S569 456315 APAPPPLsQDVPGRA X -ATM ATM Q13315 human COP1 64326 Q8NHY2 COP1 human S387 467307 SDDSRTAsQLDEFQE X X -ATM ATM Q13315 human CtIP 5932 Q99708 RBBP8 human S745 448392 SCLADSFsQAADEEE X -ATM ATM Q13315 human XPA 7507 P23025 XPA human S173 460697 VKkNPHHsQWGDMKL XPA_C X -ATM ATM Q13315 human RNF20 56254 Q5VTR2 RNF20 human S545 482124 PDsEDLSsQSsAsKA X -ATM ATM Q13315 human KIFC1 3833 Q9BW19 KIFC1 human S26 477789 RPLIkAPsQLPLsGs X -ATM ATM Q13315 human PKM 5315 P14618 PKM human T328 481749 GkPVICAtQMLESMI PK X -ATM ATM Q13315 human CHD-4 1108 Q14839 CHD4 human S1349 481897 QVNYNDGsQEDRDWQ DUF1087 X -ATM ATM Q13315 human MRE11A 4361 P49959 MRE11 human S676 460788 tSsskIMsQsQVsKG X X 4859 -ATM ATM Q13315 human SLX4 84464 Q8IY92 SLX4 human S1716 11952924 GSDSSLSsQSSSSCE X -ATM ATM Q13315 human ZNF420 147923 Q8TAQ5 ZNF420 human S68 7669300 NTYETELsQWEMSDR X -ATM ATM Q13315 human DNAPK 5591 P78527 PRKDC human T2647 448713 QQHDFtLtQTADGRs DNAPKcs_CC5 X -ATM ATM Q13315 human HUWE1 10075 Q7Z6Z7 HUWE1 human S3695 11952915 ENVVIVAsQkRPLGG X -ATM ATM Q13315 human DBN1 56320 Q9QXS6 Dbn1 mouse S658 472365 SEGyFsQsQEEEFAQ X -ATM ATM Q13315 human NUSAP1 51203 Q9BXS6 NUSAP1 human S124 482179 QNHEKQEsQDLRATA X -ATM ATM Q13315 human RAD18 56852 Q9NS91 RAD18 human S403 482231 TSVTNHFsQSKLDsP X 14978; 8393 -ATM ATM Q13315 human DNAPK 5591 P78527 PRKDC human S2612 448711 MFVEtQAsQGtLQtR DNAPKcs_CC5 X -ATM ATM Q13315 human Cortactin 2017 Q14247 CTTN human S113 465664 skLskHCsQVDsVrG HS1_rep X X -ATM ATM Q13315 human WHSC1 7468 O96028 NSD2 human S102 481737 DAkLRFEsQEMKGIG X -ATM ATM Q13315 human ZNF207 7756 O43670 ZNF207 human S104 56818116 LEQktQEsQKKKQQD X -ATM ATM Q13315 human USP34 9736 Q70CQ2 USP34 human S1751 11952929 NIHIkDAsQTTLLDL X -ATM ATM Q13315 human FMIP 8563 Q13769 THOC5 human S312 467901 EDsQDDEsDsDAEEE FmiP_Thoc5 X -ATM ATM Q13315 human MED1 5469 Q15648 MED1 human S874 11952943 PDLLNsQsQSGFGEE X -ATM ATM Q13315 human HSP90A 3320 P07900 HSP90AA1 human T5 448319 ___MPEEtQtQDQPM X 3488 -ATM ATM Q13315 human ZBTB2 57621 Q8N680 ZBTB2 human S115 11952921 IQEASLAsQGAFSHP BTB X -ATM ATM Q13315 human RNF40 9810 O75150 RNF40 human S819 11952909 EQVLGLksQVDAQLL X -ATM ATM Q13315 human KHDRBS1 10657 Q07666 KHDRBS1 human S390 34500272 YEGYysQsQGDSEyy Sam68-YY X -ATM ATM Q13315 human MDM2 4193 Q00987 MDM2 human T419 448132 KEFEREEtQDKEEsV X -ATM ATM Q13315 human Abraxas 84142 Q6UWZ7 ABRAXAS1 human S404 25173562 MkGFGEYsRsPtF__ X -ATM ATM Q13315 human p63 8626 Q9H3D4 TP63 human S479 4668107 MNKLPsVsQLINPQQ X X -ATM ATM Q13315 human DCK 1633 P27707 DCK human S74 456305 EFEELtMsQkNGGNV dNK X X 40371 -ATM ATM Q13315 human KHSRP 8570 Q92945 KHSRP human S274 482097 MILIQDGsQNtNVDk KH_1 X X -ATM ATM Q13315 human p53 24842 P10361 Tp53 rat S15 447490 MsIELPLsQEtFsCL P53_TAD X 9284; 9286; 12571; 56979 -ATM ATM Q13315 human BMAL1 406 O00327 BMAL1 human S183 1884110700 VFKILNYsQNDLIGQ X -ATM ATM Q13315 human IKKA 1147 O15111 CHUK human S473 487499 KNTLISAsQQLKAKL IKBKB_SDD X -ATM ATM Q13315 human DBF4 10926 Q9UBU7 DBF4 human T449 23010416 DDIRQNFtQLPLHkN X X -ATM ATM Q13315 human WRAP53 55135 Q9BUR4 WRAP53 human S64 482238 PVAGSAVsQELREGD X -ATM ATM Q13315 human KIBRA 23286 Q8IX03 WWC1 human T1006 54400801 RTWHSQLtQEISVLK X X -ATM ATM Q13315 human RNF40 9810 O75150 RNF40 human S114 18710201 ALLRCHEsQGELSSA X X -ATM ATM Q13315 human p53 7157 P04637 TP53 human S20 447529 PLsQEtFsDLWkLLP P53_TAD X 9287 -ATM ATM Q13315 human ESCO2 157570 Q56NI9 ESCO2 human S196 1881957102 SNAPRVLsQKIKPQV X -ATM ATM Q13315 human MRE11A 4361 P49959 MRE11 human S264 486366 EQQLFYIsQPGSSVV X -ATM ATM Q13315 human GLUT1 6513 P11166 SLC2A1 human S490 477830 FHPLGADsQV_____ X X -ATM ATM Q13315 human USP15 9958 Q9Y4E8 USP15 human S678 11952926 LPSENENsQSEDSVG UCH X -ATM ATM Q13315 human LARP7 51574 Q4G0J3 LARP7 human T440 1869962000 ANREECRtQEKVNAt X -ATM ATM Q13315 human RFA2 6118 P15927 RPA2 human S23 448337 GAGGYtQsPGGFGsP X -ATM ATM Q13315 human BRCA1 672 P38398 BRCA1 human S1542 450009 EEQQLEEsGPHDLtE X -ATM ATM Q13315 human Chk2 11200 O96017 CHEK2 human S35 447550 sQGSSsQsQGIssss X 2665 -ATM ATM Q13315 human TDP1 55775 Q9NUW8 TDP1 human S365 11952937 TPGrFQGsQkDNWGH Tyr-DNA_phospho X -ATM ATM Q13315 human BLM 641 P54132 BLM human T122 450959 PKEVVCTtQNtPtVk BLM_N X -ATM ATM Q13315 human SIM2 6493 Q14190 SIM2 human S115 1385533600 ASVHLGLsQVELTGN PAS X -ATM ATM Q13315 human RASSF1 iso2 11186 Q9NS23-2 RASSF1 human S131 486364 EWETPDLsQAEIEQK X X -ATM ATM Q13315 human RANBP9 10048 Q96S59 RANBP9 human S181 54363506 kFSYIGLsQNNLRVH X X -ATM ATM Q13315 human RAP80 20184 Q5U5Q9 Uimc1 mouse S402 482139 TTSRGQSsQGLFVEE X -ATM ATM Q13315 human SMC3 9126 Q9UQE7 SMC3 human S787 482312 ELGtDLLsQLsLEDQ SMC_N X -ATM ATM Q13315 human UBR5 51366 O95071 UBR5 human S1679 11952919 SDSDSSSsQSDDIEQ X -ATM ATM Q13315 human FBXO31 79791 Q5XUX0 FBXO31 human S278 13216200 LMKFIytsQYDNCLt X X -ATM ATM Q13315 human GIT2 9815 Q14161 GIT2 human T195 38539203 VYGADPGtQDSSGKT Ank_2 X -ATM ATM Q13315 human ATM 472 Q13315 ATM human S1981 448797 sLAFEEGsQSTtIss X X 4526; 5883; 13050 -ATM ATM Q13315 human MYST1 84148 Q9H7Z6 KAT8 human T392 34424910 LSQMTSItQNDIIST MOZ_SAS X X -ATM ATM Q13315 human USP2 9099 O75604 USP2 human T137 1880716200 YDQGVTLtQKLDsQs X -ATM ATM Q13315 human USP28 57646 Q96RU2 USP28 human S714 467253 ESSTNSSsQDYSTsQ X -ATM ATM Q13315 human RFWD3 55159 Q6PCD5 RFWD3 human S46 11952911 VPADVVSsQGVPSIL X -ATM ATM Q13315 human Smc1 8243 Q14683 SMC1A human S951 460802 kGtMDDIsQEEGssQ SMC_N X -ATM ATM Q13315 human p300 2033 Q09472 EP300 human S106 14652802 GPGQVMAsQAQQSSP X X -ATM ATM Q13315 human RAD50 10111 Q92878 RAD50 human S635 453831 KLFDVCGsQDFEsDL X X 14223; 74778 -ATM ATM Q13315 human DNAPK 5591 P78527 PRKDC human S3205 452351 tPLPEDNsMNVDQDG FAT X -ATM ATM Q13315 human NBS1 4683 O60934 NBN human S278 449968 VDTGITNsQTLIPDC NIBRIN_BRCT_II X X -ATM ATM Q13315 human TIF1B 10155 Q13263 TRIM28 human S824 460839 LPGAGLssQELsGGP X 4127 -ATM ATM Q13315 human Chk2 11200 O96017 CHEK2 human T68 447491 SsLEtVstQELYsIP X X 2197; 2661; 28130; 12812; 82263; 64180; 59068 -ATM ATM Q13315 human Ku70 2547 P12956 XRCC6 human S33 50247606 AsGDykYsGRDsLIF X -ATM ATM Q13315 human SRPK1 6732 Q96SB4 SRPK1 human T326 25724401 ENPPNKMtQEKLEEs X -ATM ATM Q13315 human TET1 80312 Q8NFU7 TET1 human S1971 1881549502 SEADEPPsDEPLsDD X X -ATM ATM Q13315 human FANCI 55215 Q9NVI1 FANCI human S559 11952935 SLSSsQCsQSLSVsQ FANCI_HD2 X -ATM ATM Q13315 human RFA2 6118 P15927 RPA2 human T21 448340 yGGAGGYtQsPGGFG X X -ATM ATM Q13315 human TTC5 219022 Q99LG4 Ttc5 mouse S203 12559514 TGQNPKIsQQALSAY X -ATM ATM Q13315 human H2AX 3014 P16104 H2AX human S139 448841 GkkAtQAsQEy____ X 2577; 9719; 9720; 9718; 4309; 5763; 5438; 93629; 80312; 20304; 85410; 97148; 60566; 59141 -ATM ATM Q13315 human TAO1 57551 Q7L7X3 TAOK1 human T785 3627516 SINEMLStQALRLDE X -ATM ATM Q13315 human ESCO2 157570 Q56NI9 ESCO2 human T233 1881957104 NEPSLGRtQKSKSEV X -ATM ATM Q13315 human RNF20 56254 Q5VTR2 RNF20 human S522 3201825 sGsALLQsQsstEDP X -ATM ATM Q13315 human GLTSCR2 29997 Q9NZM5 NOP53 human T289 60120300 PATEQAAtQESTFQE Nop53 X -ATM ATM Q13315 human GLTSCR2 29997 Q9NZM5 NOP53 human S233 23110061 ARLHTKPsQAPAVEV Nop53 X -ATM ATM Q13315 human MDM4 4194 O15151 MDM4 human S403 474540 DLAHSSEsQETISSM X X -ATM ATM Q13315 human RAD17 5884 O75943 RAD17 human S656 447756 SASELPAsQPQPFSA X X 6981 -ATM ATM Q13315 human NHEJ1 79840 Q9H9Q4 NHEJ1 human S251 4084900 AsLQGIDsQCVNQPE X -ATM ATM Q13315 human WRN 7486 Q14191 WRN human S1141 481875 PEKAYSSsQPVISAQ X -ATM ATM Q13315 human AMPKA2 5563 P54646 PRKAA2 human T172 448026 sDGEFLRtsCGsPNy Pkinase X 2535; 2531; 5256; 50081; 74281 -ATM ATM Q13315 human DNAPK 5591 P78527 PRKDC human T4102 1881979000 EsGLSEEtQVkCLMD X X -ATM ATM Q13315 human CtIP 225182 Q80YR6 Rbbp8 mouse T855 27427901 WEVGFPStQTCLERG SAE2 X -ATM ATM Q13315 human MED1 5469 Q15648 MED1 human S1147 11952941 SsQSKNSsQsGGKPG X -ATM ATM Q13315 human TOPBP1 11073 Q92547 TOPBP1 human S492 460804 QADEDLLsQyENGss X -ATM ATM Q13315 human separase 9700 Q14674 ESPL1 human S1660 1269647504 ADQLQGLsLQEMPGD X X -ATM ATM Q13315 human DAXX 1616 Q9UER7 DAXX human S564 27571800 LEEESPVsQLFELEI X X -ATM ATM Q13315 human 4E-BP1 1978 Q13541 EIF4EBP1 human S94 476291 DEPPMEAsQSHLRNs eIF_4EBP X -ATM ATM Q13315 human TRIM24 8805 O15164 TRIM24 human S768 481699 TsLLLNSsQSstSEE X X -ATM ATM Q13315 human HBXIP 10542 O43504 LAMTOR5 human S26 482652 VGVLCTDsQGLNLGC LAMTOR5 X X -ATM ATM Q13315 human FMIP 8563 Q13769 THOC5 human S314 467902 sQDDEsDsDAEEEQt FmiP_Thoc5 X -ATM ATM Q13315 human DBF4 10926 Q9UBU7 DBF4 human S539 482262 GLItINSsQEHLTVQ X X -ATM ATM Q13315 human Chk2 11200 O96017 CHEK2 human T26 447547 sQPHGsVtQsQGSSs X -ATM ATM Q13315 human NBS1 4683 O60934 NBN human S615 460790 VPEssKIsQENEIGK X X -ATM ATM Q13315 human p53 7157 P04637 TP53 human S15 447490 PsVEPPLsQEtFsDL P53_TAD X X 4030; 9235; 9284; 9286; 8695; 8514; 82530; 56979 -ATM ATM Q13315 human NFAT5 10725 O94916 NFAT5 human S1367 452032 LVQGSPSsQEQQVTL X -ATM ATM Q13315 human TOPBP1 11073 Q92547 TOPBP1 human S1138 482079 PDVNTEPsQNEQIIW X -ATM ATM Q13315 human SMARCA4 6597 P51532 SMARCA4 human S721 481804 VDDEyGVsQALARGL X X -ATM ATM Q13315 human TDP1 55775 Q9NUW8 TDP1 human S81 11279401 PKRQKsGsQEDLGWC X X -ATM ATM Q13315 human PTEN 5728 P60484 PTEN human S113 33636428 EDLDQWLsEDDNHVA X X -ATM ATM Q13315 human NBS1 4683 O60934 NBN human S397 460791 EQKFRMLsQDAPtVK X X -ATM ATM Q13315 human RNF20 56254 Q5VTR2 RNF20 human S172 18710200 SSSEEMEsQLQERVE X X -ATM ATM Q13315 human UBR5 51366 O95071 UBR5 human S2586 11952920 LRQLILAsQSSDADA HECT X -ATM ATM Q13315 human BUB3 9184 O43684 BUB3 human S135 1876205008 PCNAGtFsQPEkVyT X X -ATM ATM Q13315 human COPS3 26572 O88543 Cops3 mouse S410 482300 FVQKsMGsQEDDSGN X -ATM ATM Q13315 human Artemis 64421 Q96SD1 DCLRE1C human S647 38410204 STNADsQsssDFEVP X -ATM ATM Q13315 human DYRK2 8445 Q92630 DYRK2 human S442 11489909 IELLGMPsQKLLDAs Pkinase X -ATM ATM Q13315 human SIAH1 6477 Q8IUQ4 SIAH1 human S19 2840508 GtSkCPPsQRVPALT X X -ATM ATM Q13315 human EWS 2130 Q01844 EWSR1 human T79 7359501 QPPTGYTtPTAPQAY X -ATM ATM Q13315 human COPS1 2873 Q13098 GPS1 human S474 467704 ksPPREGsQGELtPA X -ATM ATM Q13315 human USP52 9924 Q504Q3 PAN2 human S1003 50792538 TKSTIkPsQMSVARI RNase_T X X -ATM ATM Q13315 human RAD9A 5883 Q99638 RAD9A human S272 447824 LSDtDSHsQDLGsPE X X -ATM ATM Q13315 human MLH1 4292 P40692 MLH1 human S406 12217082 PLSkPLSsQPQAIVT X -ATM ATM Q13315 human FMIP 8563 Q13769 THOC5 human S307 467900 LFKPPEDsQDDEsDs FmiP_Thoc5 X -ATM ATM Q13315 human TRIM24 8805 O15164 TRIM24 human S808 3174917 kSEWLDPsQKsPLHV X X -ATM ATM Q13315 human NBS1 27354 Q9R207 Nbn mouse T278 449968 VDVGITNtQLIISHS NIBRIN_BRCT_II X -ATM ATM Q13315 human FANCI 55215 Q9NVI1 FANCI human S556 11952934 VLGSLSSsQCsQSLS FANCI_HD2 X -ATM ATM Q13315 human MLLT1 4298 Q03111 MLLT1 human S394 40666501 SDSDFEPsQNHsQGP X -ATM ATM Q13315 human polybromo 1 55193 Q86U86 PBRM1 human S948 453717 SGLHRTYsQDCSFKN X 82088 -ATM ATM Q13315 human EYA3 2140 Q99504 EYA3 human S266 460853 PSTsPsLsQttPsKD X -ATM ATM Q13315 human USP28 57646 Q96RU2 USP28 human S67 467252 DERVkEPsQDtVATE X -ATM ATM Q13315 human UBQLN4 56893 Q9NRR5 UBQLN4 human S318 482228 GNSDsSSsQPLRTEN X -ATM ATM Q13315 human MED1 5469 Q15648 MED1 human S953 481921 LMEHHsGsQGPLLTT X -ATM ATM Q13315 human MDM2 4193 Q00987 MDM2 human S429 11956707 KEEsVESsLPLNAIE X X -ATM ATM Q13315 human PPP2R1A 51792 Q76MZ3 Ppp2r1a mouse S401 1880515600 VIGIRQLsQSLLPAI X X -ATM ATM Q13315 human DDX1 1653 Q92499 DDX1 human S377 36406801 DEADGLLsQGysDFI DEAD X X -ATM ATM Q13315 human SPOP 8405 O43791 SPOP human S119 1874115101 EETKAMEsQRAYRFV MATH X -ATM ATM Q13315 human matrin 3 9782 P43243 MATR3 human S208 452690 DyDHGsRsQEsGyyD X -ATM ATM Q13315 human PEX5 5830 P50542 PEX5 human S141 50389701 DYNETDWsQEFISEV X -NTRK1 TrkA P04629 human SH2-B-beta 25970 Q9NRF2 SH2B1 human Y753 408589400 PRAINNQySFV____ X -NTRK1 TrkA P04629 human CTNNB1 1499 P35222 CTNNB1 human Y142 449044 AVVNLINyQDDAELA X X -NTRK1 TrkA P04629 human TrkA iso2 4914 P04629-2 NTRK1 human Y490 447762 HIIENPQyFSDACVH X 9141; 4619 -NTRK1 TrkA P04629 human TrkA iso2 4914 P04629-2 NTRK1 human Y674 447763 RDIySTDyyRVGGRT PK_Tyr_Ser-Thr X -NTRK1 TrkA P04629 human TrkA 4914 P04629 NTRK1 human Y680 447763 RDIySTDyyRVGGRT PK_Tyr_Ser-Thr X X 4621 -NTRK1 TrkA P04629 human SHC3 iso2 53358 Q92529-2 SHC3 human Y218 451254 GDGSDHPyyNSIPSK X -NTRK1 TrkA P04629 human SHC3 iso2 53358 Q92529-2 SHC3 human Y256 451255 FAGKEQTyyQGRHLG X -NTRK1 TrkA P04629 human TrkA iso2 4914 P04629-2 NTRK1 human Y670 449759 FGMSRDIySTDyyRV PK_Tyr_Ser-Thr X -NTRK1 TrkA P04629 human TrkA 4914 P04629 NTRK1 human Y496 447762 HIIENPQyFSDACVH X 9141; 4619 -NTRK1 TrkA P04629 human STAT3 6774 P40763 STAT3 human Y705 448192 DPGsAAPyLktKFIC X X 4093; 9145; 4324; 9131; 9138; 4323; 4074; 4113; 48313; 20977; 25023; 8119; 52075; 52527; 73533; 61958; 73452; 16185; 74309 -NTRK1 TrkA P04629 human SHC1 iso2 6464 P29353-2 SHC1 human Y317 448511 ELFDDPSyVNVQNLD X -NTRK1 TrkA P04629 human PLCG1 5335 P19174 PLCG1 human Y771 448575 IGtAEPdyGALyEGR X -NTRK1 TrkA P04629 human PLCG1 5335 P19174 PLCG1 human Y783 447667 EGRNPGFyVEANPMP X 2821; 14461; 14008; 25678; 88717 -NTRK1 TrkA P04629 human TrkA iso2 4914 P04629-2 NTRK1 human Y675 447764 DIySTDyyRVGGRTM PK_Tyr_Ser-Thr X -NTRK1 TrkA P04629 human TrkA iso2 4914 P04629-2 NTRK1 human Y751 449758 RACPPEVyAIMRGCW PK_Tyr_Ser-Thr X -NTRK1 TrkA P04629 human TrkA 4914 P04629 NTRK1 human Y681 447764 DIySTDyyRVGGRTM PK_Tyr_Ser-Thr X X 4621 -NTRK1 TrkA P04629 human TrkA iso2 4914 P04629-2 NTRK1 human Y785 447765 LAQAPPVyLDVLG__ X 4168 -NTRK1 TrkA P04629 human SHC3 iso2 53358 Q92529-2 SHC3 human Y301 451259 PTGEAPTyVNTQQIP X -NTRK1 TrkA P04629 human SHC3 iso2 53358 Q92529-2 SHC3 human Y257 451256 AGKEQTyyQGRHLGD X -NTRK1 TrkA P04629 human SHC3 iso2 53358 Q92529-2 SHC3 human Y283 451257 RQGSSDIySTPEGKL X -NTRK1 TrkA P04629 human SHC3 iso2 53358 Q92529-2 SHC3 human Y219 451258 DGSDHPyyNSIPSKM X -Wee1 Wee1 P47810 mouse CDK1 12534 P11440 Cdk1 mouse Y15 447610 EKIGEGtyGVVyKGR Pkinase X 4539; 9111; 14566; 77897 -PKN3 PKN3 Q6P5Z2 human EGFR 1956 P00533 EGFR human T678 448053 RHIVRKRtLRRLLQE X 14343 -PKN3 PKN3 Q6P5Z2 human Restin 6249 P30622 CLIP1 human S312 4769833 AsLKRsPsAssLsSM X -MAP2K1 MEK1 P29678 rabbit MEK1 100009316 P29678 MAP2K1 rabbit Y300 2133800 PGRPLsSyGMDSRPP Pkinase X -MAP2K1 MEK1 P29678 rabbit ERK2 26413 P63085 Mapk1 mouse Y185 447594 HtGFLtEyVAtRWYR Pkinase X 9106; 4370; 4374; 9101; 4375; 4376; 4377; 3510; 5726; 88569; 13214; 13148; 70235; 9488; 89967; 8544; 14196; 14227; 14095; 14474; 75165; 98168; 33370; 54240; 15892; 45899; 55088; 9524; 69217; 48735 -MAP2K1 MEK1 P29678 rabbit MEK1 100009316 P29678 MAP2K1 rabbit S298 448284 RtPGRPLsSyGMDSR Pkinase X -MAP2K1 MEK1 P29678 rabbit ERK2 26413 P63085 Mapk1 mouse T183 447593 HDHtGFLtEyVAtRW Pkinase X 9106; 4370; 4374; 9101; 4375; 4376; 4377; 3510; 5726; 88569; 13214; 13148; 70235; 9488; 89967; 8544; 14196; 14227; 14095; 14474; 75165; 98168; 33370; 54240; 15892; 45899; 55088; 9524; 69217; 48735 -MAP2K1 MEK1 P29678 rabbit ERK2 116590 P63086 Mapk1 rat T183 447593 HDHtGFLtEyVAtRW Pkinase X 9106; 4370; 4374; 9101; 4375; 4376; 4377; 3510; 5726; 88569; 13214; 13148; 70235; 9488; 89967; 8544; 14196; 14227; 14095; 14474; 75165; 98168; 33370; 54240; 15892; 45899; 55088; 9524; 69217; 48735 -MAP2K1 MEK1 P29678 rabbit ERK1 5595 P27361 MAPK3 human T202 447542 HDHtGFLtEyVAtRW Pkinase X 9106; 4370; 4374; 9101; 4375; 4376; 4377; 3510; 5726; 88569; 13214; 13148; 70235; 9488; 89967; 8544; 14196; 14227; 14095; 14474; 75165; 98168; 33370; 54240; 15892; 45899; 55088; 9524; 69217; 48735 -MAP2K1 MEK1 P29678 rabbit ERK1 5595 P27361 MAPK3 human Y204 447543 HtGFLtEyVAtRWyr Pkinase X 9106; 4370; 4374; 9101; 4375; 4376; 4377; 3510; 5726; 88569; 13214; 13148; 70235; 9488; 89967; 8544; 14196; 14227; 14095; 14474; 75165; 98168; 33370; 54240; 15892; 45899; 55088; 9524; 69217; 48735 -Atm ATM Q62388 mouse MCM3 17215 P25206 Mcm3 mouse S732 475062 sQEKtDDsQEtQDsQ X -Atm ATM Q62388 mouse MCM3 17215 P25206 Mcm3 mouse S725 475061 HtPKtDDsQEKtDDs X -Atm ATM Q62388 mouse LKB1 20869 Q9WTK7 Stk11 mouse T366 448151 IEDGIIytQDFTVPG X X -Atm ATM Q62388 mouse MCM3 4172 P25205 MCM3 human S728 475062 HtPKtADsQETkEsQ X -Atm ATM Q62388 mouse PTEN 19211 O08586 Pten mouse S398 4695758 PFDEDQHsQITKV__ X -Atm ATM Q62388 mouse MDM2 4193 Q00987 MDM2 human S395 447898 sQESEDysQPSTSSS X -Atm ATM Q62388 mouse LKB1 20869 Q9WTK7 Stk11 mouse S431 448147 sNKIRRLsACKQQ__ X X 3482 -Atm ATM Q62388 mouse IKKG 8517 Q9Y6K9 IKBKG human S85 458399 ELLHFQAsQREEKEF NEMO X X -Atm ATM Q62388 mouse p53 22059 P02340 Tp53 mouse S18 447490 IsLELPLsQEtFsGL P53_TAD X 9284; 9286; 12571; 56979 -Atm ATM Q62388 mouse Abl 25 P00519 ABL1 human S446 450296 PYPGIDLsQVYELLE PK_Tyr_Ser-Thr X -Atm ATM Q62388 mouse CREB 12912 Q01147 Creb1 mouse S107 451811 sVDsVTDsQKRREIL pKID X -Atm ATM Q62388 mouse SYN1 iso3 20964 O88935-3 Syn1 mouse S656 472577 APPRPSLsQDEVKAE X -Atm ATM Q62388 mouse ATM 11920 Q62388 Atm mouse S1987 448797 SPTFEEGsQGTTIsS X X -Atm ATM Q62388 mouse Smc1 24061 Q9CU62 Smc1a mouse S957 448697 ISQEEGSsQGEESVS SMC_N X 4805; 58052 -Atm ATM Q62388 mouse H2AX 15270 P27661 H2ax mouse S139 448841 GkKAsQAsQEy____ X X 2577; 9719; 9720; 9718; 4309; 5763; 5438; 93629; 80312; 20304; 85410; 97148; 60566; 59141 -Atm ATM Q62388 mouse CtIP 225182 Q80YR6 Rbbp8 mouse T855 27427901 WEVGFPStQTCLERG SAE2 X -Atm ATM Q62388 mouse USP15 14479 Q8R5H1 Usp15 mouse S678 11952926 LPSENENsQSEDSVG UCH X -Atm ATM Q62388 mouse p53 7157 P04637 TP53 human S15 447490 PsVEPPLsQEtFsDL P53_TAD X 4030; 9235; 9284; 9286; 8695; 8514; 82530; 56979 -Atm ATM Q62388 mouse TIF1B 21849 Q62318 Trim28 mouse S824 460839 LPSAGLssQELSGPG X 4127 -MAPK13 P38D O15264 human MAFA O57342 MAFA quail T57 456028 LSSTPLStPCSSVPS X X -MAPK13 P38D O15264 human MEF2D 4209 Q14814 MEF2D human S180 449933 LTDPRLLsPQQPALQ X -MAPK13 P38D O15264 human PSD-95 29495 P31016 Dlg4 rat T287 469607 TDyPtAMtPTsPRRY PDZ_assoc X -MAPK13 P38D O15264 human PRKD1 18760 Q62101 Prkd1 mouse S403 4169976 EDSNRtIsPstsNNI X -MAPK13 P38D O15264 human EEF2K 29904 O00418 EEF2K human S396 450812 TFDsLPssPssAtPH X -MAPK13 P38D O15264 human Tau iso8 4137 P10636-8 MAPT human S396 449081 GAEIVyKsPVVsGDt X 9632 -MAPK13 P38D O15264 human Tau iso8 4137 P10636-8 MAPT human S404 449082 PVVsGDtsPRHLsNV X 35834; 20194; 98523; 91600; 49562 -MAPK13 P38D O15264 human MEF2D 4209 Q14814 MEF2D human S121 2246700 EDKyRRAsEELDGLF HJURP_C X -MAPK13 P38D O15264 human PRKD1 18760 Q62101 Prkd1 mouse S407 3196826 RtIsPstsNNIPLMR X -MAPK13 P38D O15264 human MEF2D 4209 Q14814 MEF2D human S251 3196577 NkVIPAksPPPPtHS X -MAPK13 P38D O15264 human STMN1 3925 P16949 STMN1 human S25 448555 QAFELILsPrskEsV Stathmin X X -MAPK13 P38D O15264 human ISL1 3670 P61371 ISL1 human S269 515814094 GTPMVAAsPERHDGG X -MAPK13 P38D O15264 human MEF2D 4209 Q14814 MEF2D human S275 1883583402 PDLRVITsQAGKGLM X -MAPK13 P38D O15264 human STMN1 3925 P16949 STMN1 human S38 448556 sVPEFPLsPPkKkDL Stathmin X X 3426; 4191 -MAPK13 P38D O15264 human SQSTM1 8878 Q13501 SQSTM1 human T269 457004 GGkRsRLtPVsPEss X X 13121 -MAPK13 P38D O15264 human CCND3 896 P30281 CCND3 human T283 452160 QGPsQtstPtDVtAI X 53966 -MAPK13 P38D O15264 human MAFA O57342 MAFA quail T113 456029 NPEALNLtPEDAVEA Maf_N X X -MAPK13 P38D O15264 human PRKD1 18760 Q62101 Prkd1 mouse S748 448590 GEksFRRsVVGtPAy Pkinase X 2054 -MAPK13 P38D O15264 human DLG1 25252 Q62696 Dlg1 rat T209 35547401 VNTDSLEtPTYVNGT MAGUK_N_PEST X -MAPK13 P38D O15264 human MEF2D 4209 Q14814 MEF2D human S472 31862283 EPGDGLssPAGGSYE X -MAPK13 P38D O15264 human GYS1 2997 P13807 GYS1 human S723 4787599 sssLStPsEPLsPts X -MAPK13 P38D O15264 human EEF2K 29904 O00418 EEF2K human S359 447826 GtEEKCGsPQVRtLs X X -MAPK13 P38D O15264 human Tau iso8 4137 P10636-8 MAPT human T217 449078 sRtPsLPtPPtREPK X 33134; 51625 -MAPK13 P38D O15264 human HSF1 3297 Q00613 HSF1 human S307 449046 EPPsPPQsPRVEEAs Vert_HS_TF X -MAPK13 P38D O15264 human DLG1 25252 Q62696 Dlg1 rat S442 5931300 YLGQTPAsPARYsPI PDZ_assoc X -MAPK13 P38D O15264 human STMN1 29332 P13668 Stmn1 rat S25 448555 QAFELILsPRSKESV Stathmin X -MAPK13 P38D O15264 human NALP1 22861 Q9C000 NLRP1 human S107 1880261804 PSEPHLGsPSQPTST X -MAPK13 P38D O15264 human MEF2D 4209 Q14814 MEF2D human S444 449407 SIkSEPVsPsRERsP X X -MAPK13 P38D O15264 human HSF1 3297 Q00613 HSF1 human S303 449045 RVkEEPPsPPQsPRV Vert_HS_TF X -MAPK13 P38D O15264 human Tip60 iso2 10524 Q92993-2 KAT5 human T106 10800707 VEVVsPAtPVPSETA X X -MAPK13 P38D O15264 human DLG1 25252 Q62696 Dlg1 rat S158 2024309 FVSHSHIsPIKPTEA MAGUK_N_PEST X -MAPK13 P38D O15264 human PRKD1 18760 Q62101 Prkd1 mouse S203 449896 GVRRRRLsNVsLTGL X -MAPK13 P38D O15264 human Tau iso8 4137 P10636-8 MAPT human T212 447934 tPGsRsRtPsLPtPP X -MAPK13 P38D O15264 human GYS1 2997 P13807 GYS1 human S727 457615 StPsEPLsPtssLGE X -MAPK13 P38D O15264 human MEF2D 4209 Q14814 MEF2D human S231 3196574 GYVsARAsPGLLPVA X -MAPK13 P38D O15264 human HSF1 3297 Q00613 HSF1 human S326 455484 ssVDtLLsPTALIDs Vert_HS_TF X -MAPK13 P38D O15264 human PRKD1 18760 Q62101 Prkd1 mouse S255 449897 GREKRsNsQSYIGRP X -MAPK13 P38D O15264 human MAFA O57342 MAFA quail S272 456030 RGFPRETsPPAAPKT X X -MAPK13 P38D O15264 human GYS1 2997 P13807 GYS1 human T278 1875332700 kRkPDIVtPNGLNVk Glycogen_syn X -MAPK13 P38D O15264 human SQSTM1 8878 Q13501 SQSTM1 human S272 454787 RsRLtPVsPEssstE X X 13121 -MAPK13 P38D O15264 human Tip60 10524 Q92993 KAT5 human T158 10800707 VEVVsPAtPVPSETA X X -MAPK13 P38D O15264 human PRKD1 18760 Q62101 Prkd1 mouse S206 455754 RRRLsNVsLTGLGtV X -MYO3A MYO3A Q8NEV4 human MYO3A 53904 Q8NEV4 MYO3A human T919 29674701 TRHARETtNMKTQTV Myosin_head X -MYO3A MYO3A Q8NEV4 human MYO3A 53904 Q8NEV4 MYO3A human T184 29674700 stRHRRNtSVGtPFW Pkinase X -MYO3A MYO3A Q8NEV4 human MYO3A 53904 Q8NEV4 MYO3A human T908 29674702 INLAKGDtGEATRHA Myosin_head X -MYO3A MYO3A Q8NEV4 human MYO3A 53904 Q8NEV4 MYO3A human T178 23252211 VSAQLTstRHRRNtS Pkinase X -MYO3A MYO3A Q8NEV4 human MYO3A 53904 Q8NEV4 MYO3A human T188 36841901 RRNtSVGtPFWMAPE Pkinase X -FYN Fyn P06241 human DAB1 iso1 ABR15760 DAB1 pig Y197 447961 SQKKEGVyDVPKSQP X -FYN Fyn P06241 human NMDAR2A 2903 Q12879 GRIN2A human Y1118 11267004 SSPRDKIyTIDGEKE NMDAR2_C X -FYN Fyn P06241 human ITCH 83737 Q96J02 ITCH human Y420 454077 QFNQRFIyGNQDLFA X -FYN Fyn P06241 human NMT1 4836 P30419 NMT1 human Y180 10336300 YTLLNENyVEDDDNM NMT X -FYN Fyn P06241 human DCBLD2 131566 Q96PD2 DCBLD2 human Y750 454600 PAPDELVyQVPQStQ X -FYN Fyn P06241 human DCC 25311 Q63155 Dcc rat Y1261 454410 PTLESAQyPGILPsP Neogenin_C X -FYN Fyn P06241 human CD5 921 P06127 CD5 human Y453 447774 AsHVDNEysQPPRNs X -FYN Fyn P06241 human SLAP-130 2533 O15117 FYB1 human Y651 452095 LDMGDEVyDDVDTSD X -FYN Fyn P06241 human SLAP-130 2533 O15117 FYB1 human Y625 23144933 PPPDDDIydGIEEED X -FYN Fyn P06241 human PLCG2 5336 P16885 PLCG2 human Y753 447940 ERDINSLyDVsRMyV X -FYN Fyn P06241 human Abl 25 P00519 ABL1 human Y393 450298 RLMtGDtytAHAGAk PK_Tyr_Ser-Thr X 2865 -FYN Fyn P06241 human IFITM3 10410 Q01628 IFITM3 human Y20 463584 NSGQPPNyEMLkEEH X -FYN Fyn P06241 human DCBLD2 131566 Q96PD2 DCBLD2 human Y715 455062 PPPLVGtyNtLLsRt X -FYN Fyn P06241 human ARHGAP3 1124 P52757 CHN2 human Y21 482808 VSSDAEEyQPPIWKS X X -FYN Fyn P06241 human SNX26 115703 O14559 ARHGAP33 human Y406 465993 PLLTYQLyGKFSEAM RhoGAP X -FYN Fyn P06241 human NMDAR2A 2903 Q12879 GRIN2A human Y1246 458210 CLRMGNLyDIDEDQM NMDAR2_C X 4206 -FYN Fyn P06241 human Ig-alpha 12518 P11911 Cd79a mouse Y182 473649 DyEDENLyEGLNLDD ITAM X 14948; 5173; 14732; 29742; 52821; 17749 -FYN Fyn P06241 human PAG 55824 Q9NWQ8 PAG1 human Y317 450659 EEEIsAMyssVNKPG PAG X -FYN Fyn P06241 human SKAP55 8631 Q86WV1 SKAP1 human Y232 451308 EEEKEETyDDIDGFD X -FYN Fyn P06241 human DCBLD2 131566 Q96PD2 DCBLD2 human Y565 458665 KKkTEGtyDLPyWDR X -FYN Fyn P06241 human NMDAR2A 2903 Q12879 GRIN2A human Y1105 4109553 CSEVERTyLKTKSSS NMDAR2_C X -FYN Fyn P06241 human DCBLD2 131566 Q96PD2 DCBLD2 human S657 1869653003 ADLDPyNsPGQEVyH X -FYN Fyn P06241 human DAB1 iso2 13131 P97318-2 Dab1 mouse Y200 447960 VEDPVyQyIVFEAGH X -FYN Fyn P06241 human CRMP-1 1400 Q14194 CRMP1 human Y504 454682 GMyDGPVyEVPAtPK X -FYN Fyn P06241 human SCN5A 6331 Q14524 SCN5A human Y1494 455659 MTEEQKkyyNAMKKL X -FYN Fyn P06241 human PECAM-1 5175 P16284 PECAM1 human Y690 448759 PLNsDVQytEVQVSS X -FYN Fyn P06241 human MAP2 iso3 4133 P11137-3 MAP2 human Y67 454429 EHGSQGTySNTKENG X -FYN Fyn P06241 human calponin 3 54321 P37397 Cnn3 rat Y261 452163 SQKGMSVyGLGRQVY Calponin X -FYN Fyn P06241 human LKB1 20869 Q9WTK7 Stk11 mouse Y365 13258701 DIEDGIIytQDFTVP X X -FYN Fyn P06241 human DCC 25311 Q63155 Dcc rat Y1418 454409 TEDPASVyEQDDLSE Neogenin_C X -FYN Fyn P06241 human STAM2 10254 O75886 STAM2 human Y371 449670 LVNEAPVysVysKLH X -FYN Fyn P06241 human APP 351 P05067 APP human Y757 448202 SkMQQNGyENPtykF APP_amyloid X -FYN Fyn P06241 human Hic-5 7041 O43294 TGFB1I1 human Y60 450964 SGDKDHLystVCKPR Paxillin X -FYN Fyn P06241 human IFITM3 66141 Q9CQW9 Ifitm3 mouse Y27 482855 yERIkEEyEVAEMGA X -FYN Fyn P06241 human SLAM 6504 Q13291 SLAMF1 human Y281 447633 EKKsLtIyAQVQKPG X -FYN Fyn P06241 human Cortactin 2017 Q14247 CTTN human Y470 447703 AyATEAVyESAEAPG X -FYN Fyn P06241 human calponin 1 65204 Q08290 Cnn1 rat Y261 452161 SQRGMTVyGLPRQVY Calponin X -FYN Fyn P06241 human CENTG1 iso2 116986 Q99490-2 AGAP2 human Y682 467224 ESWIRAKyEQLLFLA ArfGap X X -FYN Fyn P06241 human GABRG2 14406 P22723 Gabrg2 mouse Y413 455818 ERDEEyGyECLDGKD Neur_chan_memb X -FYN Fyn P06241 human Lmr1 iso2 11302 Q80YE4-2 Aatk mouse Y46 4269100 AQTGPDVyVLPLTEV X X -FYN Fyn P06241 human CTNND1 12388 P30999 Ctnnd1 mouse Y228 449648 yPGGsDNyGsLsRVT X 2911 -FYN Fyn P06241 human BSG iso2 682 P35613-2 BSG human Y140 1868502601 PVTDWAWyKITDSED Ig_3 X X -FYN Fyn P06241 human SLAM 6504 Q13291 SLAMF1 human Y307 448264 QDPCTTIyVAATEPV X -FYN Fyn P06241 human NPHS1 54631 Q9QZS7 Nphs1 mouse Y1191 2299202 MAFPGHLyDEVERVY X X -FYN Fyn P06241 human FLOT1 10211 O75955 FLOT1 human Y160 462262 DIHDDQDyLHsLGkA Band_7 X -FYN Fyn P06241 human NPHS1 64563 Q9R044 Nphs1 rat Y1212 6377601 DEVRMDPyDLRWPEV X -FYN Fyn P06241 human Fyn 2534 P06241 FYN human Y28 447879 sLNQssGyRyGTDPT X -FYN Fyn P06241 human DCBLD2 131566 Q96PD2 DCBLD2 human Y569 473074 EGtyDLPyWDRAGWW X -FYN Fyn P06241 human STAM2 10254 O75886 STAM2 human Y291 474371 kSEPEPVyIDEDkMD X -FYN Fyn P06241 human PTPRJ 5795 Q12913 PTPRJ human Y1320 15228667 NtTAMtIyENLAPVT X -FYN Fyn P06241 human Abl 25 P00519 ABL1 human Y128 459259 SLEKHSWyHGPVSRN SH2 X -FYN Fyn P06241 human PTPRJ 5795 Q12913 PTPRJ human Y1311 473909 DSkVDLIyQNtTAMt X -FYN Fyn P06241 human NPHS1 64563 Q9R044 Nphs1 rat Y1171 6377603 PTLEEVLyHQGAEGE X -FYN Fyn P06241 human BSG iso2 682 P35613-2 BSG human Y183 38486780 MEADPGQyRCNGTSS Ig_3 X X -FYN Fyn P06241 human FLOT2 2319 Q14254 FLOT2 human Y163 475941 DVYDkVDyLSsLGkT Band_7 X -FYN Fyn P06241 human H3F3A 3020 P84243 H3-3A human S10 18545301 tkQTARkstGGkAPR Histone X X 9706; 3458 -FYN Fyn P06241 human NPHS1 64563 Q9R044 Nphs1 rat Y1228 469566 CEDPRGIyDQVAADM X -FYN Fyn P06241 human NPHS1 64563 Q9R044 Nphs1 rat Y1152 6377604 TAEVDPNyySMRDFS X -FYN Fyn P06241 human DAB1 100037307 A1Y2K0 DAB1 pig Y198 447629 EDVEDPVyQyIVFEA X -FYN Fyn P06241 human PXN iso2 5829 P49023-2 PXN human Y118 448604 VGEEEHVysFPNKQK Paxillin X 2541; 69363 -FYN Fyn P06241 human FCGR2B 2213 P31994 FCGR2B human Y292 448507 GAENTITysLLMHPD X -FYN Fyn P06241 human NMDAR2A 2903 Q12879 GRIN2A human Y1267 461052 PATGEQVyQQDWAQN NMDAR2_C X -FYN Fyn P06241 human LKB1 20869 Q9WTK7 Stk11 mouse Y261 13258700 PFEGDNIyKLFENIG Pkinase X X -FYN Fyn P06241 human RSK2 6197 P51812 RPS6KA3 human Y483 464202 IItLkDVyDDGKyVY Pkinase X -FYN Fyn P06241 human DCBLD2 131566 Q96PD2 DCBLD2 human Y655 478857 GyADLDPyNsPGQEV X -FYN Fyn P06241 human NPHS1 64563 Q9R044 Nphs1 rat Y1153 1317600 AEVDPNyySMRDFSP X -FYN Fyn P06241 human PPP2CA 5515 P67775 PPP2CA human Y307 448571 VTRRtPDyFl_____ X -FYN Fyn P06241 human Abl 25 P00519 ABL1 human Y226 450303 KRNKPtVyGVsPNyD X 2868; 2861 -FYN Fyn P06241 human SNCA 6622 P37840 SNCA human Y125 448279 VDPDNEAyEMPsEEG Synuclein X -FYN Fyn P06241 human SCN5A 6331 Q14524 SCN5A human Y1495 455660 TEEQKkyyNAMKKLG X X -FYN Fyn P06241 human Fyn 2534 P06241 FYN human Y39 447881 TDPTPQHyPSFGVTS X -FYN Fyn P06241 human SKAP55 8631 Q86WV1 SKAP1 human Y295 460296 TRRKGVDyASyyQGL X -FYN Fyn P06241 human PPP2CA 5515 P67775 PPP2CA human Y284 457325 ELDDTLkySFLQFDP X -FYN Fyn P06241 human NOX4 50507 Q9NPH5 NOX4 human Y566 57848101 LSNQNNSyGTRFEYN X -FYN Fyn P06241 human Fyn 2534 P06241 FYN human Y214 455043 KLDNGGyyITtRAQF SH2 X -FYN Fyn P06241 human Cortactin 2017 Q14247 CTTN human Y446 448776 GtEPEPVysMEAADy X -FYN Fyn P06241 human LKB1 20869 Q9WTK7 Stk11 mouse Y166 13258702 QLIDGLEyLHSQGIV Pkinase X -FYN Fyn P06241 human PLXNA2 5362 O75051 PLXNA2 human Y1677 1121331800 sKMVSEIyLTRLLAT Plexin_cytopl X -FYN Fyn P06241 human CD3E 916 P07766 CD3E human Y199 448917 RKGQRDLysGLNQRR ITAM X -FYN Fyn P06241 human Abl 25 P00519 ABL1 human Y115 450305 QGWVPsNyItPVNSL X -FYN Fyn P06241 human STAT3 6774 P40763 STAT3 human Y705 448192 DPGsAAPyLktKFIC X 4093; 9145; 4324; 9131; 9138; 4323; 4074; 4113; 48313; 20977; 25023; 8119; 52075; 52527; 73533; 61958; 73452; 16185; 74309 -FYN Fyn P06241 human KIRREL 170643 Q80W68 Kirrel1 mouse Y719 455014 SQLSyENyEKFNSHP X -FYN Fyn P06241 human CBL 867 P22681 CBL human Y774 448531 sENEDDGyDVPKPPV X 3555 -FYN Fyn P06241 human PLEKHG1 57480 Q9ULL1 PLEKHG1 human Y661 15502837 IDDIDHVyDNISYED X X -FYN Fyn P06241 human FCGR2A 2212 P12318 FCGR2A human Y288 449553 yEtADGGyMtLNPRA X -FYN Fyn P06241 human Abl 25 P00519 ABL1 human Y215 469589 GLITTLHyPAPKRNK X -FYN Fyn P06241 human Abl 25 P00519 ABL1 human Y70 462900 PNLFVALyDFVAsGD SH3_1 X 3098 -FYN Fyn P06241 human Fyn 2534 P06241 FYN human Y213 451536 RKLDNGGyyITtRAQ SH2 X -FYN Fyn P06241 human Nogo 57142 Q9NQC3 RTN4 human Y694 470039 LQETEAPyISIACDL X -FYN Fyn P06241 human DAB1 100037307 A1Y2K0 DAB1 pig Y200 447960 VEDPVyQyIVFEAGH X -FYN Fyn P06241 human DCBLD2 131566 Q96PD2 DCBLD2 human Y649 473121 EEGKEAGyADLDPyN X -FYN Fyn P06241 human CD133 8842 O43490 PROM1 human Y828 462569 RMDsEDVyDDVEtIP X -FYN Fyn P06241 human CLIC5 53405 Q9NZA1 CLIC5 human Y33 3081200 EENESPHyDDVHEYL X -FYN Fyn P06241 human CENTG1 iso2 116986 Q99490-2 AGAP2 human Y774 467225 QGRTALFyARQAGSQ Ank_2 X X -FYN Fyn P06241 human RSK2 6197 P51812 RPS6KA3 human Y707 448775 KGAMAAtysALNRNQ X -FYN Fyn P06241 human NPHS1 64563 Q9R044 Nphs1 rat Y1204 469565 PGAWGPLyDEVRMDP X -FYN Fyn P06241 human NMDAR2A 2903 Q12879 GRIN2A human Y943 461053 SDkGNLMysDNRSFQ NMDAR2_C X -FYN Fyn P06241 human IP3R1 3708 Q14643 ITPR1 human Y353 450970 NAQEKMVySLVSVPE MIR X X -FYN Fyn P06241 human PTPRT iso1 11122 O14522-1 PTPRT human Y915 11315001 GYGFKEEyEALPEGQ X -FYN Fyn P06241 human Fyn 2534 P06241 FYN human Y420 447882 RLIEDNEytARQGAk PK_Tyr_Ser-Thr X X 2101; 6943; 59548; 70926; 78740; 94361; 17320 -FYN Fyn P06241 human Tau iso8 4137 P10636-8 MAPT human Y18 454024 MEDHAGtyGLGDRKD X -FYN Fyn P06241 human PSD-95 1742 P78352 DLG4 human Y523 4093600 REDSVLSyETVTQME X X -FYN Fyn P06241 human CD300LB 124599 A8K4G0 CD300LB human Y188 975498 EPGEQPIyMNFSEPL X -FYN Fyn P06241 human DAB1 iso2 13131 P97318-2 Dab1 mouse Y185 447959 KQCEQAVyQTILEED X -FYN Fyn P06241 human SLAP-130 2533 O15117 FYB1 human Y571 454079 TTAVEIDyDsLkLKK X X -FYN Fyn P06241 human SKAP55 8631 Q86WV1 SKAP1 human Y298 460297 KGVDyASyyQGLWDC X -FYN Fyn P06241 human calponin 1 65204 Q08290 Cnn1 rat Y182 452162 sQQGMTAyGTRRHLY Calponin X -FYN Fyn P06241 human DAB1 iso2 13131 P97318-2 Dab1 mouse Y198 447629 EDVEDPVyQyIVFEA X -FYN Fyn P06241 human CTNND1 12388 P30999 Ctnnd1 mouse Y112 472275 PGQIVETyTEEDPEG X -FYN Fyn P06241 human NMDAR2A 2903 Q12879 GRIN2A human Y1325 458211 RLLEGNFyGSLFSVP NMDAR2_C X -FYN Fyn P06241 human SLAP-130 2533 O15117 FYB1 human Y771 449430 ADNDGEIyDDIAdGC hSH3 X -FYN Fyn P06241 human PLXNA2 5362 O75051 PLXNA2 human Y1605 474307 VPKQTSSyNIPASAs Plexin_cytopl X -FYN Fyn P06241 human cytohesin 1 19157 Q9QX11 Cyth1 mouse Y382 464074 AISRDPFyEMLAARK X -FYN Fyn P06241 human caveolin-1 857 Q03135 CAV1 human Y14 448422 VDsEGHLytVPIREQ X X 3251 -FYN Fyn P06241 human Bcr 613 P11274 BCR human Y177 447792 ADAEKPFyVNVEFHH X 3901 -FYN Fyn P06241 human DBNL 13169 Q62418 Dbnl mouse Y340 450090 QTEEEPTyEVPPEQD X -FYN Fyn P06241 human CD3E 916 P07766 CD3E human Y188 448918 PPVPNPDyEPIRKGQ ITAM X -FYN Fyn P06241 human GRB10 2887 Q13322 GRB10 human Y67 448348 NASLESLySACSMQS X X -FYN Fyn P06241 human SLAP-130 2533 O15117 FYB1 human Y559 15149800 GRTARGsyGyIKTTA SH3_2 X -FYN Fyn P06241 human KIRREL 310695 Q6X936 Kirrel1 rat Y637 463751 MKDPTNGyyNVRAHE X X -FYN Fyn P06241 human CTNNG 3728 P14923 JUP human Y133 456971 AIVHLINyQDDAELA X -FYN Fyn P06241 human NRF2 4780 Q16236 NFE2L2 human Y576 460703 RDEDGkPysPSEYSL X -FYN Fyn P06241 human PLXNA1 5361 Q9UIW2 PLXNA1 human Y1679 1121331801 sKMVSEIyLTRLLAT Plexin_cytopl X -FYN Fyn P06241 human MAP2 iso3 4133 P11137-3 MAP2 human Y50 2792500 RSANGFPyREDEEGA X -FYN Fyn P06241 human PLCG2 5336 P16885 PLCG2 human Y759 447941 LyDVsRMyVDPsEIN X 3874; 50535 -FYN Fyn P06241 human RSK2 6197 P51812 RPS6KA3 human Y529 464205 TITKTVEyLHAQGVV Pkinase X X -FYN Fyn P06241 human EFTU 281556 P49410 TUFM cow Y115 55372798 INAAHVEySTAARHY GTP_EFTU X -FYN Fyn P06241 human KIRREL 310695 Q6X936 Kirrel1 rat Y638 463752 KDPTNGyyNVRAHED X X -FYN Fyn P06241 human RSK2 6197 P51812 RPS6KA3 human Y580 3455194 GLLMtPCytANFVAP Pkinase X -FYN Fyn P06241 human Lmr1 iso2 11302 Q80YE4-2 Aatk mouse Y25 4269101 ENAEGDEyVADFSEQ X X -FYN Fyn P06241 human CD133 8842 O43490 PROM1 human Y852 462570 GYHkDHVyGIHNPVM X -FYN Fyn P06241 human HER2 2064 P04626 ERBB2 human Y877 448694 LDIDEtEyHADGGkV PK_Tyr_Ser-Thr X 2241 -FYN Fyn P06241 human DLC1 50768 Q9R0Z9 Dlc1 mouse Y702 1869008601 SAEDNVNyEGQSAYD RhoGAP X -FYN Fyn P06241 human IFITM3 66141 Q9CQW9 Ifitm3 mouse Y20 463584 SGGQPPNyERIkEEy X -FYN Fyn P06241 human PECAM-1 5175 P16284 PECAM1 human Y713 448760 KKDtEtVysEVRKAV X -FYN Fyn P06241 human DCBLD2 131566 Q96PD2 DCBLD2 human Y621 454599 LQADsAEyAQPLVGG X -FYN Fyn P06241 human TRIO 310192 F1M0Z1 Trio rat Y2685 27425000 LLNPNYIyDVPPEFV X -FYN Fyn P06241 human Abl 25 P00519 ABL1 human Y139 456712 VSRNAAEyLLsSGIN SH2 X -FYN Fyn P06241 human Cortactin 2017 Q14247 CTTN human Y486 447704 yPAEDStyDEYENDL X -FYN Fyn P06241 human DCBLD2 131566 Q96PD2 DCBLD2 human Y732 455063 CssAQAQyDtPKAGk X -FYN Fyn P06241 human CRMP-4 25418 Q62952 Dpysl3 rat Y32 464893 VNDDQSFyADIYMED X -FYN Fyn P06241 human PRC1 9055 O43663 PRC1 human Y464 474466 QTETEMLyGsAPRtP MAP65_ASE1 X -FYN Fyn P06241 human KIRREL 170643 Q80W68 Kirrel1 mouse Y716 455015 DTTSQLSyENyEKFN X -FYN Fyn P06241 human DCBLD2 131566 Q96PD2 DCBLD2 human Y677 475112 LPITGPEyAtPIIMD X -FYN Fyn P06241 human EFTU 281556 P49410 TUFM cow Y246 474427 LLDAVDTyIPVPTRD GTP_EFTU X -FYN Fyn P06241 human Cortactin 2017 Q14247 CTTN human Y421 447702 rLPssPVyEDAAsFK X 4569 -FYN Fyn P06241 human Fyn 2534 P06241 FYN human Y30 447880 NQssGyRyGTDPTPQ X -FYN Fyn P06241 human SKAP2 54353 Q3UND0 Skap2 mouse Y260 449668 QPIDDEIyEELPEEE X X -FYN Fyn P06241 human RSK2 6197 P51812 RPS6KA3 human Y470 478835 EIEILLRyGQHPNII Pkinase X -FYN Fyn P06241 human STAM2 10254 O75886 STAM2 human Y374 449671 EAPVysVysKLHPPA X -FYN Fyn P06241 human DLC1 50768 Q9R0Z9 Dlc1 mouse Y452 1869008602 NVPGSILySSSGELA X -FYN Fyn P06241 human SLAP-130 2533 O15117 FYB1 human Y595 452094 IEDDQEVyDDVAEQD X X -FYN Fyn P06241 human DCBLD2 131566 Q96PD2 DCBLD2 human S618 23097815 TTVLQADsAEyAQPL X -FYN Fyn P06241 human KIRREL 170643 Q80W68 Kirrel1 mouse Y638 463752 kDPTNGyyNVRAHED X X -FYN Fyn P06241 human AMPKA2 5563 P54646 PRKAA2 human Y436 58109404 EWKVVNAyHLRVRRK AdenylateSensor X X -FYN Fyn P06241 human PGD 5226 P52209 PGD human Y481 465221 GtVSSssyNA_____ X X -FYN Fyn P06241 human P38A 1432 Q16539 MAPK14 human Y323 455799 DEPVADPyDQsFESR X -FYN Fyn P06241 human IREM-1 146722 Q8TDQ1 CD300LF human Y263 474549 AEDQEPTyCNMGHLS X -FYN Fyn P06241 human DCBLD2 131566 Q96PD2 DCBLD2 human Y666 478858 GQEVyHAyAEPLPIT X -FYN Fyn P06241 human Ig-beta 15985 P15530 Cd79b mouse Y195 459286 GMEEDHTyEGLNIDQ ITAM X -FYN Fyn P06241 human SCN9A 6335 Q15858 SCN9A human Y1482 1121331802 TEEQKkyyNAMKKLG X -FYN Fyn P06241 human CTNNB1 12387 Q02248 Ctnnb1 mouse Y142 449044 AVVNLINyQDDAELA X -FYN Fyn P06241 human SLAM 6504 Q13291 SLAMF1 human Y327 447634 ETNSITVyASVTLPE X -FYN Fyn P06241 human CBL 867 P22681 CBL human Y700 448529 EGEEDtEyMtPssRP X 8869 -FYN Fyn P06241 human DAB1 iso1 ABR15760 DAB1 pig Y185 447959 KQCEQAVyQVPTSQK X -FYN Fyn P06241 human DAB1 100037307 A1Y2K0 DAB1 pig Y232 447961 SQKKEGVyDVPKSQP X -FYN Fyn P06241 human Abl 25 P00519 ABL1 human Y172 460505 LRyEGRVyHyRINTA SH2 X -FYN Fyn P06241 human CD5 921 P06127 CD5 human Y487 447775 DNssDsDyDLHGAQR X -FYN Fyn P06241 human COX-2 5743 P35354 PTGS2 human Y446 484179 DQSRQMkyQSFNEYR An_peroxidase X -FYN Fyn P06241 human DAB1 iso2 13131 P97318-2 Dab1 mouse Y232 447961 SQKKEGVyDVPKSQP X -FYN Fyn P06241 human GUCY1B1 54195 O54865 Gucy1b1 mouse Y192 469612 ESKEEDFyEDLDRFE X -FYN Fyn P06241 human Siglec-10 89790 Q96LC7 SIGLEC10 human Y667 450087 ESQEELHyATLNFPG X -FYN Fyn P06241 human RSK2 6197 P51812 RPS6KA3 human Y644 473285 KFSLSGGyWNSVSDT Pkinase X -FYN Fyn P06241 human CRMP-2 25416 P47942 Dpysl2 rat Y32 463168 VNDDQSFyADIYMED X X -FYN Fyn P06241 human PBK 55872 Q96KB5 PBK human Y272 54400800 DFDDEAYyAALGTRP Pkinase X X -FYN Fyn P06241 human TIGIT 201633 Q495A1 TIGIT human Y225 27266400 DCAELHDyFNVLSYR X -FYN Fyn P06241 human NMDAR2A 2903 Q12879 GRIN2A human Y1187 476853 NNDQyKLySKHFTLK NMDAR2_C X -FYN Fyn P06241 human GABRG2 14406 P22723 Gabrg2 mouse Y411 455817 LQERDEEyGyECLDG Neur_chan_memb X -FYN Fyn P06241 human PLEKHG1 57480 Q9ULL1 PLEKHG1 human Y742 1876191900 QAVEENIyDTIGLPD X X -FYN Fyn P06241 human DCBLD2 131566 Q96PD2 DCBLD2 human Y663 3974132 NsPGQEVyHAyAEPL X -FYN Fyn P06241 human PTPRT iso1 11122 O14522-1 PTPRT human Y1030 458414 WPDDTEVyGDIKVTL Y_phosphatase X -FYN Fyn P06241 human SCN9A 6335 Q15858 SCN9A human Y1481 1121331803 MTEEQKkyyNAMKKL X -FYN Fyn P06241 human SLAP-130 2533 O15117 FYB1 human Y755 464285 CRNEEGkyGyVLRSy hSH3 X -FYN Fyn P06241 human NPHS1 54631 Q9QZS7 Nphs1 mouse Y1208 469565 PGVWGPLyDEVQMDP X X -FYN Fyn P06241 human FAK 25614 O35346 Ptk2 rat Y928 447966 DRSNDKVyENVTGLV Focal_AT X 3284 -FYN Fyn P06241 human DBNL 13169 Q62418 Dbnl mouse Y350 450091 PPEQDTLyEEPPLVQ X -FYN Fyn P06241 human NPHS1 64563 Q9R044 Nphs1 rat Y1194 6377600 HDEVERAyGPPGAWG X -FYN Fyn P06241 human Fyn 2534 P06241 FYN human Y185 465282 sETtkGAysLsIRDW SH2 X -FYN Fyn P06241 human Cortactin 2017 Q14247 CTTN human Y453 449517 ysMEAADyREASSQQ X -FYN Fyn P06241 human Abl 25 P00519 ABL1 human Y185 450304 TAsDGKLyVsSESRF SH2 X 3009 -FYN Fyn P06241 human CBL 867 P22681 CBL human Y731 448530 QQIDSCTyEAMyNIQ X X 3554 -FYN Fyn P06241 human DAB1 100037307 A1Y2K0 DAB1 pig Y185 447959 KQCEQAVyQTILEED X -FYN Fyn P06241 human RSK2 6197 P51812 RPS6KA3 human Y488 464203 DVyDDGKyVYVVTEL Pkinase X -FYN Fyn P06241 human hnRNP P2 2521 P35637 FUS human Y526 50318713 QDrrErPy_______ X -FYN Fyn P06241 human CTNND1 12388 P30999 Ctnnd1 mouse Y96 449495 QDHNHLLystIPRMQ X -FYN Fyn P06241 human SHP-2 5781 Q06124 PTPN11 human Y542 448492 sKRkGHEytNIKysL X 3751; 94740; 15543; 64117 -FYN Fyn P06241 human MAP2 4133 P11137 MAP2 human Y67 454429 EHGsQGtySNTKENG X -FYN Fyn P06241 human PLXNA1 5361 Q9UIW2 PLXNA1 human Y1608 458728 VPKQTSAyNISNSSt Plexin_cytopl X -FYN Fyn P06241 human DNAM-1 10666 Q15762 CD226 human Y322 454845 DDTREDIyVNyPTFs X -FYN Fyn P06241 human KIRREL 170643 Q80W68 Kirrel1 mouse Y637 463751 MkDPTNGyyNVRAHE X X -FYN Fyn P06241 human NMDAR2B 14812 Q01097 Grin2b mouse Y1070 461055 IsTHtVTyGNIEGNA NMDAR2_C X 4209 -FYN Fyn P06241 human LKB1 20869 Q9WTK7 Stk11 mouse Y156 13258703 PVCQAHGyFRQLIDG Pkinase X -FYN Fyn P06241 human LKB1 20869 Q9WTK7 Stk11 mouse Y60 448152 DLLGEGSyGKVKEVL Pkinase X -FYN Fyn P06241 human CTNNG 3728 P14923 JUP human Y550 456972 AAGtQQPytDGVRME X -FYN Fyn P06241 human ADD2 119 P35612 ADD2 human Y489 449419 PNQFVPLyTDPQEVL X -FYN Fyn P06241 human SLAP-130 2533 O15117 FYB1 human Y757 464286 NEEGkyGyVLRSyLA hSH3 X -FYN Fyn P06241 human NPHS1 64563 Q9R044 Nphs1 rat Y1127 6377602 EDRIRNEyEESQWTG X -FYN Fyn P06241 human IREM-1 146722 Q8TDQ1 CD300LF human Y236 474548 VDQVEVEyVTMASLP SIT X -FYN Fyn P06241 human SLAP-130 2533 O15117 FYB1 human Y780 459246 DIAdGCIyDND____ hSH3 X -FYN Fyn P06241 human IKKG 8517 Q9Y6K9 IKBKG human Y374 473650 PLPPAPAyLssPLAL X -FYN Fyn P06241 human PKACA 5566 P17612 PRKACA human Y70 1269647501 HKETGNHyAMKILDK Pkinase X -Camk1 CAMK1A Q91YS8 mouse PPM1H 319468 Q3UYC0 Ppm1h mouse S210 3215799 RTLTRAAsLrGGVGA X X -TTK TTK P33981 human USP16 10600 Q9Y5T5 USP16 human S415 3217536 VEDEDQDsEEEKDND UCH X -TTK TTK P33981 human HSP90A 3320 P07900 HSP90AA1 human T115 13256102 GtIAksGtkAFMEAL HATPase_c X -TTK TTK P33981 human TTK 7272 P33981 TTK human S742 4145509 QQIINQIsKLHAIID Pkinase X -TTK TTK P33981 human BLM 641 P54132 BLM human S1296 452326 TsPAEDssPGISLSs X -TTK TTK P33981 human TTK 7272 P33981 TTK human T46 41389704 NKISADttDNsGTVN X -TTK TTK P33981 human USP16 10600 Q9Y5T5 USP16 human T554 3217539 EVLtssPtRNLNGAY UCH X -TTK TTK P33981 human Abl 25 P00519 ABL1 human T735 450291 DTEWRSVtLPRDLQS X X 2864 -TTK TTK P33981 human TTK 7272 P33981 TTK human T288 6370307 sPDCDVktDDsVVPC X X -TTK TTK P33981 human TTK 7272 P33981 TTK human T33 2846502 kFkNEDLtDELsLNK X X -TTK TTK P33981 human HSPA9B 3313 P38646 HSPA9 human T62 483967 VVGIDLGtTNsCVAV HSP70 X -TTK TTK P33981 human TTK 7272 P33981 TTK human S321 3189826 SkPsGNDsCELRNLk X -TTK TTK P33981 human TTK 7272 P33981 TTK human T12 13194901 DLsGRELtIDsIMNk X X -TTK TTK P33981 human MAD1L1 8379 Q9Y6D9 MAD1L1 human S22 5024704 RsLNNFIsQRVEGGs X -TTK TTK P33981 human ARHGEF17 9828 Q96PE2 ARHGEF17 human T1007 54363501 APsLEDVtKQYMLNL X -TTK TTK P33981 human MAD1L1 8379 Q9Y6D9 MAD1L1 human S610 334535801 ELKKQVEsAELkNQR MAD X -TTK TTK P33981 human TTK 7272 P33981 TTK human T371 1737600 LLAkLEEtkEyQEPE X -TTK TTK P33981 human TTK 7272 P33981 TTK human T849 4145517 HNSsSsktFEkkRGK X -TTK TTK P33981 human MAD1L1 8379 Q9Y6D9 MAD1L1 human S62 334535803 AEQIRSksHLIQVER MAD X -TTK TTK P33981 human ARHGEF17 9828 Q96PE2 ARHGEF17 human T944 54363500 DEGsQDQtGsLsRAR X -TTK TTK P33981 human TTK 7272 P33981 TTK human T795 4145512 HPYVQIQtHPVNQMA X -TTK TTK P33981 human MAP4 4134 P27816 MAP4 human S928 468166 SRLAtNtsAPDLkNV Tubulin-binding X X -TTK TTK P33981 human Borealin 55143 Q53HL2 CDCA8 human T230 4203200 DskEIFLtVPVGGGE Borealin X -TTK TTK P33981 human BUB1B 701 O60566 BUB1B human S670 3207630 TLsIkkLsPIIEDsR X -TTK TTK P33981 human TTK 7272 P33981 TTK human T686 487541 VkDSQVGtVNYMPPE Pkinase X X -TTK TTK P33981 human TTK 7272 P33981 TTK human S821 467281 GQLVGLNsPNsILkA X -TTK TTK P33981 human TTK 7272 P33981 TTK human T676 487540 NQMQPDttsVVkDSQ Pkinase X X -TTK TTK P33981 human NCAPH2 29781 Q6IBW4 NCAPH2 human S492 459636 FVQEtELsQRIRDWE CNDH2_C X X -TTK TTK P33981 human ARHGEF17 9828 Q96PE2 ARHGEF17 human T751 54363502 AATSEEPtGFSVDSN X -TTK TTK P33981 human USP16 10600 Q9Y5T5 USP16 human S552 449274 DLEVLtssPtRNLNG UCH X -TTK TTK P33981 human BLM 641 P54132 BLM human S1290 467080 QKYSEWTsPAEDssP X -TTK TTK P33981 human TTK 7272 P33981 TTK human S847 4145515 ESHNSsSsktFEkkR X -TTK TTK P33981 human MAD1L1 8379 Q9Y6D9 MAD1L1 human T8 41286654 MEDLGENtMVLstLR X -TTK TTK P33981 human TTK 7272 P33981 TTK human S7 4272730 _MEsEDLsGRELtID X -TTK TTK P33981 human Borealin 55143 Q53HL2 CDCA8 human T94 4203201 AtADLDItEINkLtA X -TTK TTK P33981 human TTK 7272 P33981 TTK human S362 13194902 TLKNktEssLLAkLE X -TTK TTK P33981 human TTK 7272 P33981 TTK human T45 1880463702 LNKISADttDNsGTV X -TTK TTK P33981 human BUB1B 701 O60566 BUB1B human S1043 483373 WkVGkLtsPGALLFQ X -TTK TTK P33981 human MAD1L1 8379 Q9Y6D9 MAD1L1 human S598 18911590 AAASLPsskEVAELK MAD X -TTK TTK P33981 human BLM 641 P54132 BLM human S144 467079 KKLEFSssPDSLSTI BLM_N X -TTK TTK P33981 human TTK 7272 P33981 TTK human S49 1880463704 SADttDNsGTVNQIM X -TTK TTK P33981 human TTK 7272 P33981 TTK human T805 4145510 VNQMAkGttEEMkyV X -TTK TTK P33981 human BUB1B 701 O60566 BUB1B human S435 3207627 REAELLtsAEkRAEM X -TTK TTK P33981 human Borealin 55143 Q53HL2 CDCA8 human T169 4203202 KRssRANtVtPAVGR Borealin X -TTK TTK P33981 human TTK 7272 P33981 TTK human S80 2846503 EkNSVPLsDALLNkL X -TTK TTK P33981 human MAP4 4134 P27816 MAP4 human T927 10422252 LSRLAtNtsAPDLkN Tubulin-binding X X -TTK TTK P33981 human Borealin 55143 Q53HL2 CDCA8 human T88 4203203 QALEEAAtADLDItE X -TTK TTK P33981 human TTK 7272 P33981 TTK human S824 3189832 VGLNsPNsILkAAkT X -TTK TTK P33981 human TTK 7272 P33981 TTK human T564 4145511 LEEADNQtLDSYRNE Pkinase X -TTK TTK P33981 human HSPA9B 3313 P38646 HSPA9 human S65 483968 IDLGtTNsCVAVMEG HSP70 X -TTK TTK P33981 human BUB1B 701 O60566 BUB1B human S543 4049929 LsEkKNksPPADPPR X -TTK TTK P33981 human TTK 7272 P33981 TTK human S37 2846500 EDLtDELsLNKISAD X X -TTK TTK P33981 human SLC4A4 8671 Q9Y6R1 SLC4A4 human S12 3951822 AVLDRGAsFLKHVCD X -TTK TTK P33981 human TTK 7272 P33981 TTK human T806 4145514 NQMAkGttEEMkyVL X -TTK TTK P33981 human Chk2 11200 O96017 CHEK2 human T68 447491 SsLEtVstQELYsIP X 2197; 2661; 28130; 12812; 82263; 64180; 59068 -TTK TTK P33981 human Borealin 55143 Q53HL2 CDCA8 human S238 9721503 VPVGGGEsLRLLAsD Borealin X -TTK TTK P33981 human TTK 7272 P33981 TTK human T675 487539 ANQMQPDttsVVkDS Pkinase X X -TTK TTK P33981 human TTK 7272 P33981 TTK human S363 1737601 LKNktEssLLAkLEE X X -TTK TTK P33981 human MAD1L1 8379 Q9Y6D9 MAD1L1 human T716 334535800 LELFSRQtVA_____ MAD X X -TTK TTK P33981 human MAD1L1 8379 Q9Y6D9 MAD1L1 human T323 334535802 SWERLDQtMGLSIRT MAD X -TTK TTK P33981 human TTK 7272 P33981 TTK human S845 4145516 GGESHNSsSsktFEk X -TTK TTK P33981 human TTK 7272 P33981 TTK human T360 1737602 sITLKNktEssLLAk X X -TTK TTK P33981 human TTK 7272 P33981 TTK human S582 4145513 LNkLQQHsDkIIRLY Pkinase X -TTK TTK P33981 human TTK 7272 P33981 TTK human S436 950200 VFSVskQsPPIsTSk X -TTK TTK P33981 human TTK 7272 P33981 TTK human Y811 459314 GttEEMkyVLGQLVG X -TTK TTK P33981 human RMI2 116028 Q96E14 RMI2 human S112 29606701 MGVVQACsPEPCLQA RMI2 X -TTK TTK P33981 human TTK 7272 P33981 TTK human S15 13194900 GRELtIDsIMNkVRD X X -TTK TTK P33981 human MAD1L1 8379 Q9Y6D9 MAD1L1 human T624 334535804 RLkEVFQtkIQEFRK MAD X -TTK TTK P33981 human TTK 7272 P33981 TTK human S677 6311911 QMQPDttsVVkDSQV Pkinase X X -GRK1 GRK1 Q15835 human Rhodopsin 509933 P02699 RHO cow S334 448677 PLGDDEAsttVsKtE X -GRK1 GRK1 Q15835 human Rhodopsin 509933 P02699 RHO cow T340 448681 AsttVsKtEtsQVAP X -GRK1 GRK1 Q15835 human Rhodopsin 509933 P02699 RHO cow T342 452181 ttVsKtEtsQVAPA_ X -GRK1 GRK1 Q15835 human GPR120 iso1 338557 Q5NUL3-1 FFAR4 human S366 31014808 GAILtDtsVKRNDLs X -GRK1 GRK1 Q15835 human occludin 18260 Q61146 Ocln mouse S507 1976701 KQLKSKLsHIKRMVG Occludin_ELL X X -GRK1 GRK1 Q15835 human Claudin-5 12741 O54942 Cldn5 mouse T207 454390 YSAPRRPtANGDyDk X X -GRK1 GRK1 Q15835 human Rhodopsin 509933 P02699 RHO cow S343 448680 tVsKtEtsQVAPA__ X -GRK1 GRK1 Q15835 human occludin 18260 Q61146 Ocln mouse T382 1976700 tPSKRAPtKGKAGKG X X -GRK1 GRK1 Q15835 human KOR-1 4986 P41145 OPRK1 human S358 1975303 RMERQSTsRVRNTVQ X -GRK1 GRK1 Q15835 human Rhodopsin 509933 P02699 RHO cow S338 448679 DEAsttVsKtEtsQV X -GRK1 GRK1 Q15835 human GPR120 iso1 338557 Q5NUL3-1 FFAR4 human T363 31014807 PEKGAILtDtsVKRN X -GRK1 GRK1 Q15835 human GPR120 iso1 338557 Q5NUL3-1 FFAR4 human S373 31014806 sVKRNDLsIIsG___ X -CSNK1A1L CK1A2 Q8N752 human NFAT5 10725 O94916 NFAT5 human S158 2715403 LLDNsRMsCQDEGCG X -PRKCA PKCA P17252 human eNOS 4846 P29474 NOS3 human T495 447885 TGITRKKtFKEVANA X 9574 -PRKCA PKCA P17252 human TACSTD2 4070 P09758 TACSTD2 human S303 451171 VITNRRKsGKYKKVE X X -PRKCA PKCA P17252 human JPH2 57158 Q9BR39 JPH2 human S165 4779179 PLRTsLssLRsEHsN X -PRKCA PKCA P17252 human TOP1 7150 P11387 TOP1 human S21 2721301 ADFRLNDsHKHKDKH X -PRKCA PKCA P17252 human CYP2E1 1571 P05181 CYP2E1 human S247 23097372 AEVKEyVsERVkEHH p450 X -PRKCA PKCA P17252 human MYBPC1 iso2 109272 G0YZM8 Mybpc1 mouse S204 4738635 IRSAFKRsGEGQEDA X -PRKCA PKCA P17252 human p40phox 4689 Q15080 NCF4 human S315 448265 RQARGLPsQKRLFPW PB1 X X -PRKCA PKCA P17252 human ANXA1 301 P04083 ANXA1 human S28 452053 yVQtVksskGGPGsA X -PRKCA PKCA P17252 human AKAP12 83425 Q5QD51 Akap12 rat S507 469987 SPLKKLFsSsGLKKL X -PRKCA PKCA P17252 human CK1D 64462 Q06486 Csnk1d rat S393 53356806 LTGRQDtsRMstsQI X -PRKCA PKCA P17252 human MARCKS 613548 P12624 MARCKS cow S162 447787 KRFsFKKsFKLsGFs MARCKS X 11992 -PRKCA PKCA P17252 human PTP1B 5770 P18031 PTPN1 human S378 448669 RSRVVGGsLrGAQAA X -PRKCA PKCA P17252 human PLCG1 5335 P19174 PLCG1 human S1248 448665 HGrAREGsFEsRyQQ X X 4510; 13349; 8713 -PRKCA PKCA P17252 human FLNC 68794 Q8VHX6 Flnc mouse S2625 15403523 sSSsRGAsySSIPKF X -PRKCA PKCA P17252 human Tau iso8 4137 P10636-8 MAPT human S352 487459 DFKDrVQskIGsLDN Tubulin-binding X -PRKCA PKCA P17252 human PPAR-alpha 25747 P37230 Ppara rat T129 457548 CKGFFRRtIRLKLAY zf-C4 X -PRKCA PKCA P17252 human CENTA1 11033 O75689 ADAP1 human T276 11380901 GFRkRWFtMDDRRLM PH X -PRKCA PKCA P17252 human SERT 6532 P31645 SLC6A4 human T603 31014805 RLIITPGtFKERIIK X -PRKCA PKCA P17252 human PACSIN2 23970 Q9WVE8 Pacsin2 mouse S313 4786393 ADLNRtLsRREKKKA X X -PRKCA PKCA P17252 human ITGB2 3689 P05107 ITGB2 human S745 448532 FEkEKLksQWNNDNP Integrin_b_cyt X -PRKCA PKCA P17252 human G-alpha(z) 2781 P19086 GNAZ human S16 451242 EKEAARRsRRIDRHL G-alpha X X -PRKCA PKCA P17252 human PCDHGA3 93711 Q91XY5 Pcdhga3 mouse S922 41590812 GNGNKKKsGKKEKK_ Cadherin_tail X -PRKCA PKCA P17252 human C5aR 728 P21730 C5AR1 human S314 450055 FQGRLRKsLPsLLRN X -PRKCA PKCA P17252 human CDC42EP4 23580 Q9H3Q1 CDC42EP4 human S18 3212334 sVHskRRsRADLtAE X X -PRKCA PKCA P17252 human ADCY6 25289 Q03343 Adcy6 rat T931 455530 HAQQVEStARLDFLW X -PRKCA PKCA P17252 human RhoGDI alpha 396 P52565 ARHGDIA human S34 467490 ykPPAQKsIQEIQEL Rho_GDI X -PRKCA PKCA P17252 human CK1D 1453 P48730 CSNK1D human T174 1871153001 YRENkNLtGtARYAs Pkinase X -PRKCA PKCA P17252 human Ku70 2547 P12956 XRCC6 human S77 1875071706 VYISKIIssDRDLLA Ku_N X X -PRKCA PKCA P17252 human CK1D 1453 P48730 CSNK1D human S181 1868926301 tGtARYAsINTHLGI Pkinase X X -PRKCA PKCA P17252 human NHERF 9368 O14745 NHERF1 human S340 455753 RAHQKRssKRAPQMD EBP50_C X X -PRKCA PKCA P17252 human PKCE 18754 P16054 Prkce mouse S368 2085101 NNIRKALsFDNRGEE X -PRKCA PKCA P17252 human TACE 6868 P78536 ADAM17 human T735 449804 kPFPAPQtPGRLQPA X -PRKCA PKCA P17252 human CK1D 64462 Q06486 Csnk1d rat S328 3190837 PATRGLPstAsGRLR X -PRKCA PKCA P17252 human RRAD 6236 P55042 RRAD human S257 457395 QIRLRRDsKEANARR X -PRKCA PKCA P17252 human SRF 6722 P11831 SRF human S162 460665 LRRYtTFsKRkTGIM SRF-TF X X -PRKCA PKCA P17252 human MT1 24567 P02803 Mt1 rat S32 7965104 KCTSCKKsCCSCCPV Metallothio X -PRKCA PKCA P17252 human VTN 7448 P04004 VTN human S393 452177 sRGRNQNsRRPsRAT X -PRKCA PKCA P17252 human ATP5C 509 P36542 ATP5F1C human S146 467518 GILYRtHsDQFLVAF ATP-synt X -PRKCA PKCA P17252 human EGLN2 112398 Q96KS0 EGLN2 human S226 4213803 LRDGQLVsQRAIPPR X -PRKCA PKCA P17252 human PPAR-alpha 5465 Q07869 PPARA human S230 2902207 VKARVILsGKASNNP X -PRKCA PKCA P17252 human TNNI3 511094 P08057 TNNI3 cow S44 450690 AKKKSKIsAsRKLQL X -PRKCA PKCA P17252 human Ezrin 7430 P15311 EZR human T567 448104 QGRDkyKtLRQIRQG ERM_C X 3141; 3726; 32600 -PRKCA PKCA P17252 human CACNA1C 100101555 P15381 CACB rabbit S1928 455278 ASLGRRAsFHLECLK CAC1F_C X X -PRKCA PKCA P17252 human p21Cip1 1026 P38936 CDKN1A human S146 447836 GRkRRQtsMTDFyHs X -PRKCA PKCA P17252 human SRF 6722 P11831 SRF human T159 449631 DNkLRRYtTFsKRkT SRF-TF X X -PRKCA PKCA P17252 human CACNA1C 12288 Q01815 Cacna1c mouse S1644 480102 QGLVGkPsQRNALsL X -PRKCA PKCA P17252 human CDC42EP4 23580 Q9H3Q1 CDC42EP4 human S80 35524901 SskRsLLsRKFRGSK PBD X X -PRKCA PKCA P17252 human GMF-beta 2764 P60983 GMFB human S72 451487 QPRFIVYsYkYQHDD Cofilin_ADF X -PRKCA PKCA P17252 human CELF1 10658 Q92879 CELF1 human S179 29668003 QtMEGCssPMVVkFA X -PRKCA PKCA P17252 human Kv11.1 3757 Q12809 KCNH2 human S890 3893409 RQRKRKLsFRRRtDK X -PRKCA PKCA P17252 human GRF-1 2909 Q9NRY4 ARHGAP35 human S1236 7159801 PKPKPRPsITKATWE RhoGAP_pG1_pG2 X -PRKCA PKCA P17252 human sialophorin 6693 P16150 SPN human S351 451340 tFFGRRKsRQGsLAM X -PRKCA PKCA P17252 human CK1D 64462 Q06486 Csnk1d rat S370 483997 MERERKVsMRLHRGA X -PRKCA PKCA P17252 human TRPV1 83810 O35433 Trpv1 rat S820 456218 QLKHYTGsLkPEDAE X -PRKCA PKCA P17252 human TRPV5 56302 Q9NQA5 TRPV5 human S299 470108 FLELVVSsDKREARQ X -PRKCA PKCA P17252 human mGluR7 81672 P35400 Grm7 rat S862 2846504 NVQKRKRsFKAVVTA X -PRKCA PKCA P17252 human NMDAR1 24408 P35439 Grin1 rat S889 449107 AITSTLAssFKRRRs X -PRKCA PKCA P17252 human FLOT1 10211 O75955 FLOT1 human S315 18750500 QAEAEAAsVRMRGEA X X -PRKCA PKCA P17252 human IGFBP1 3484 P08833 IGFBP1 human S144 451659 NFHLMAPsEEDHSIL X -PRKCA PKCA P17252 human KCNJ8 25472 Q63664 Kcnj8 rat S391 1458602 NsMRRNNsMRRSNsI X -PRKCA PKCA P17252 human FLNC 2318 Q14315 FLNC human S2624 15403523 sSssRGssyssIPkF X -PRKCA PKCA P17252 human EIF6 3692 P56537 EIF6 human S235 450271 QPstIAtsMRDsLID X X -PRKCA PKCA P17252 human SHP-2 5781 Q06124 PTPN11 human S591 469623 GLMQQQksFR_____ X -PRKCA PKCA P17252 human TNNT2 286816 P13789 TNNT2 cow S195 451755 KAQtERKsGKRQtER Troponin X -PRKCA PKCA P17252 human CELF1 10658 Q92879 CELF1 human S28 3347300 GQVPrtWsEkDLREL RRM_1 X -PRKCA PKCA P17252 human MYH9 4627 P35579 MYH9 human S1916 451181 AMNREVssLkNkLRr Myosin_tail_1 X -PRKCA PKCA P17252 human GJA1 24392 P08050 Gja1 rat S364 450183 AIVDQRPssRAssRA X -PRKCA PKCA P17252 human hnRNP A1 29578 P04256 Hnrnpa1 rat S197 2874413 SSsQRGRsGsGNFGG X -PRKCA PKCA P17252 human KCNE3 10008 Q9Y6H6 KCNE3 human S82 460569 LILGYTRsRKVDKRS ISK_Channel X -PRKCA PKCA P17252 human CTPS 1503 P17812 CTPS1 human T455 473570 MRLGKRRtLFQTkNs GATase X X -PRKCA PKCA P17252 human TRPV5 Q9XSM3 Trpv5 rabbit S654 470109 YVEAFKCsDKEDGQE X -PRKCA PKCA P17252 human H1R 3269 P35367 HRH1 human S398 450937 WKRLRsHsRQyVSGL 7tm_1 X -PRKCA PKCA P17252 human CYP2E1 1571 P05181 CYP2E1 human T69 23940005 QRFGPVFtLYVGsQR p450 X -PRKCA PKCA P17252 human MARCKS 396473 P16527 MARCKS chicken S124 447786 KKKKKRFsFKKsFKL MARCKS X 11992 -PRKCA PKCA P17252 human ANXA2 302 P07355 ANXA2 human S26 450879 tPPsAyGsVkAytNF X X -PRKCA PKCA P17252 human rabphilin 3A 171039 P47709 Rph3a rat S234 455904 GPPTRRAsEARMSTT X -PRKCA PKCA P17252 human CYP3A4 1576 P08684 CYP3A4 human T264 5938005 KEsRLEDtQKHRVDF p450 X -PRKCA PKCA P17252 human PXR 8856 O75469 NR1I2 human T408 9730704 RSINAQHtQRLLRIQ Hormone_recep X -PRKCA PKCA P17252 human RSC1A1 Q29106 RSC1A1 pig S370 10433802 LHELLVIsSKPALEN X -PRKCA PKCA P17252 human hnRNP A1 29578 P04256 Hnrnpa1 rat S95 476057 RAVSREDsQRPGAHL X -PRKCA PKCA P17252 human SLC6A2 6530 P23975 SLC6A2 human T258 465613 SLWKGVKtsGKVVWI SNF X -PRKCA PKCA P17252 human TNNI3 511094 P08057 TNNI3 cow S25 448424 PPVRRRssANYRAYA Troponin-I_N X -PRKCA PKCA P17252 human CK1D 1453 P48730 CSNK1D human S53 1868926300 HPQLHIEskIYkMMQ Pkinase X X -PRKCA PKCA P17252 human syndecan-4 24771 P34901 Sdc4 rat S183 449863 MKKKDEGsYDLGKKP Syndecan X -PRKCA PKCA P17252 human uPA 5328 P00749 PLAU human S158 451052 CADGKKPsSPPEELK X -PRKCA PKCA P17252 human p14ARF 1029 Q8N726 CDKN2A human T8 27523604 MVRRFLVtLRIRRAC P19Arf_N X -PRKCA PKCA P17252 human Claudin-4 12740 O35054 Cldn4 mouse S195 4199301 RSNDKPYsAkYsAAR X -PRKCA PKCA P17252 human CYSLTR1 10800 Q9Y271 CYSLTR1 human S315 11143521 tFRKHsLssVTYVPR X -PRKCA PKCA P17252 human HDAC4 9759 P56524 HDAC4 human S632 448490 RPLSRAQssPAsAtF X 3424 -PRKCA PKCA P17252 human IL2RA 3559 P01589 IL2RA human S268 455369 WQRRQRKsRRtI___ X X -PRKCA PKCA P17252 human SERT 6532 P31645 SLC6A4 human S149 31014804 yHRNGCIsIWRKICP SNF X -PRKCA PKCA P17252 human CFTR 1080 P13569 CFTR human S737 449981 EPLERRLsLVPDSEQ CFTR_R X -PRKCA PKCA P17252 human PPP2R5A 5525 Q15172 PPP2R5A human S41 3196904 RQKRsQGssQFRsQG X -PRKCA PKCA P17252 human TRPV4 63873 Q9EPK8 Trpv4 mouse S824 4777181 LRRDRWssVVPRVVE X -PRKCA PKCA P17252 human CFTR 1080 P13569 CFTR human T682 2907505 APVSWTEtKKQsFKQ CFTR_R X -PRKCA PKCA P17252 human RRAD 6236 P55042 RRAD human S273 457396 AGTRRREsLGKKAKR X -PRKCA PKCA P17252 human ITGB4 3691 P16144 ITGB4 human S1356 451653 ysDDVLRsPSGsQRP X -PRKCA PKCA P17252 human Kv-beta2 8514 Q13303 KCNAB2 human S266 451000 IPPYSRAsLkGYQWL Aldo_ket_red X -PRKCA PKCA P17252 human MMP2 4313 P08253 MMP2 human T377 479860 DGKMWCAttANYDDD Peptidase_M10; fn2 X -PRKCA PKCA P17252 human NMDAR2A 2903 Q12879 GRIN2A human S929 485949 ADFIQRGsLIMDMVS NMDAR2_C X -PRKCA PKCA P17252 human AQP1 358 P29972 AQP1 human T157 482806 VLCVLATtDRRRRDL MIP X X -PRKCA PKCA P17252 human CTNND1 12388 P30999 Ctnnd1 mouse S879 450459 LIDRNQKsDKKPDRE X -PRKCA PKCA P17252 human coronin 1A 12721 O89053 Coro1a mouse S426 31905585 PEPsGtPssDTVsRL Trimer_CC X -PRKCA PKCA P17252 human ITGB2 3689 P05107 ITGB2 human T758 448533 NPLFksAtttVMNPk Integrin_b_cyt X -PRKCA PKCA P17252 human DAB2 79128 O88797 Dab2 rat S24 451211 QAAPKAPsKKEKKKG X -PRKCA PKCA P17252 human CYP2E1 1571 P05181 CYP2E1 human S56 23940003 ELKNIPKsFtRLAQR p450 X -PRKCA PKCA P17252 human FLNC 2318 Q14315 FLNC human S2623 27449343 KsSssRGssyssIPk X -PRKCA PKCA P17252 human KCNMA1 282573 Q28204 KCNMA1 cow S695 456596 DEQPSTLsPKKKQRN X -PRKCA PKCA P17252 human PKCE 5581 Q02156 PRKCE human S316 2085100 tPDKITNsGQRRkKL X -PRKCA PKCA P17252 human uPA 5328 P00749 PLAU human S323 451053 TGFGKENsTDYLYPE Trypsin X -PRKCA PKCA P17252 human LRP1 4035 Q07954 LRP1 human S4523 7103863 GsRHsLAsTDEkREL X X -PRKCA PKCA P17252 human GLT1 20511 P43006 Slc1a2 mouse S562 486052 nGksADCsVEEEPWk X -PRKCA PKCA P17252 human PDE3A 5139 Q14432 PDE3A human S293 471416 FkRRRRsssVVsAEM X -PRKCA PKCA P17252 human ADD2 119 P35612 ADD2 human S726 449803 KKKEKVEs_______ X -PRKCA PKCA P17252 human ULK1 8408 O75385 ULK1 human S423 1880900310 GRAGPFSsSRCGAsV X -PRKCA PKCA P17252 human SLC29A1 63959 Q9JIM1 Slc29a1 mouse S281 21326706 PPtNRNQsIKAILKs Nucleoside_tran X -PRKCA PKCA P17252 human RRAD 6236 P55042 RRAD human S214 457394 LVRSREVsVDEGRAC Ras X -PRKCA PKCA P17252 human TRPV6 55503 Q9H1D0 TRPV6 human T742 11381600 WERLRQGtLRRDLRG X -PRKCA PKCA P17252 human DMBT1 12945 Q60997 Dmbt1 mouse S2082 13201903 IDRGQPPsTKL____ X -PRKCA PKCA P17252 human ROMK 3758 P48048 KCNJ1 human T193 2813503 KKRAKtItFSKNAVI IRK_C X -PRKCA PKCA P17252 human VTN 7448 P04004 VTN human S397 452178 NQNsRRPsRATWLSL X -PRKCA PKCA P17252 human ADRA1D 146 P25100 ADRA1D human S334 1424270003 HtFRssLsVRLLKFS 7tm_1 X -PRKCA PKCA P17252 human ITGB1 3688 P05556 ITGB1 human S785 452040 GENPIyksAVttVVN Integrin_b_cyt X -PRKCA PKCA P17252 human EGLN2 112398 Q96KS0 EGLN2 human S132 4213804 GGDAPsPsKRPWARQ X -PRKCA PKCA P17252 human calponin 1 396911 Q08092 CNN1 pig S175 450890 MGTNKFAsQQGMTAY Calponin X -PRKCA PKCA P17252 human ITGB4 iso2 3691 P16144-2 ITGB4 human S1424 465821 tLTRDyNsLTRSEHS X -PRKCA PKCA P17252 human CYP3A4 1576 P08684 CYP3A4 human S131 22553305 EEWkRLRsLLsPtFT p450 X -PRKCA PKCA P17252 human Sin1 79109 Q9BPZ7 MAPKAP1 human S128 3830292 kSLFEKKsLKEKPPI SIN1 X -PRKCA PKCA P17252 human Akt1 207 P31749 AKT1 human S473 447855 RPHFPQFsysAsGtA Pkinase_C X X 9271; 3787; 4060; 4051; 5102; 4058; 2336; 2337; 4075; 4070; 5012; 4071; 92982; 5315; 9563; 9018; 12694; 52240; 11962; 15116; 88106; 26580; 68035; 31957; 23430; 20235 -PRKCA PKCA P17252 human PPP1R14A 94274 Q96A00 PPP1R14A human T38 449098 QkRHARVtVkYDRRE PP1_inhibitor X -PRKCA PKCA P17252 human RKIP 29542 P31044 Pebp1 rat S153 448755 RGkFkVEsFRKKYHL PBP X -PRKCA PKCA P17252 human p47phox 653361 P14598 NCF1 human S320 451726 QRsRKRLsQDAYRRN NECFESHC X -PRKCA PKCA P17252 human GluR4 29629 P19493 Gria4 rat S862 448810 TRNKARLsITGSVGE X -PRKCA PKCA P17252 human p53 7157 P04637 TP53 human S376 447570 LkskkGQstsRHkkL X -PRKCA PKCA P17252 human MOR-1 18390 P42866 Oprm1 mouse S363 447783 STIEQQNsARIRQNt X X -PRKCA PKCA P17252 human NOXA1 10811 Q86UR1 NOXA1 human S172 990300 DQVQRRGsLPPRQVP X X -PRKCA PKCA P17252 human DAT 24898 P23977 Slc6a3 rat S4 454428 ____MsKsKCsVGPM X -PRKCA PKCA P17252 human 4E-BP1 116636 Q62622 Eif4ebp1 rat S64 447527 FLMECRNsPVAKtPP eIF_4EBP X 9451; 9456 -PRKCA PKCA P17252 human SCN2A 24766 P04775 Scn2a rat S610 451195 DNDSRRDsLFVPHRH Na_trans_cytopl X -PRKCA PKCA P17252 human CD4 920 P01730 CD4 human S440 469618 sQIkRLLsEKKTCQC Tcell_CD4_C X -PRKCA PKCA P17252 human RALB 5899 P11234 RALB human S198 16827200 KSSKNKKsFKERCCL X X -PRKCA PKCA P17252 human RALBP1 10928 Q15311 RALBP1 human S118 487528 VFKKPsFsKKKEKDF X -PRKCA PKCA P17252 human TNNI3 7137 P19429 TNNI3 human S23 448423 PAPIRRRssNyRAyA Troponin-I_N X 4004 -PRKCA PKCA P17252 human TUBA1C 84790 Q9BQE3 TUBA1C human S165 8046500 sVDyGkkskLEFSIy Tubulin X -PRKCA PKCA P17252 human EphA2 1969 P29317 EPHA2 human S892 3189622 ADFDPRVsIRLPsts X X -PRKCA PKCA P17252 human RhoGDI beta 397 P52566 ARHGDIB human S31 4933709 ykPPPQksLkELQEM Rho_GDI X X -PRKCA PKCA P17252 human Caldesmon 373965 P12957 CALD1 chicken S615 2873302 RAEFLNKsAQKSGMK Caldesmon X -PRKCA PKCA P17252 human SLC18A2 6571 Q05940 SLC18A2 human S15 30332702 LVRWLQEsRRsRKLI X -PRKCA PKCA P17252 human AQP4 361 P55087 AQP4 human S180 467301 TIFASCDsKRTDVTG MIP X -PRKCA PKCA P17252 human PTP-PEST 5782 Q05209 PTPN12 human S435 451312 KKLERNLsFEIKKVP X X -PRKCA PKCA P17252 human CYP3A4 1576 P08684 CYP3A4 human S100 22553303 VLVKECYsVFtNRRP p450 X -PRKCA PKCA P17252 human EGFR 1956 P00533 EGFR human T678 448053 RHIVRKRtLRRLLQE X X 14343 -PRKCA PKCA P17252 human ADCY6 25289 Q03343 Adcy6 rat S10 450817 LPVARSGsGRSSMsW X -PRKCA PKCA P17252 human GRK7 131890 Q8WTQ7 GRK7 human S36 456355 ELQRRRRsLALPGLQ X -PRKCA PKCA P17252 human NHERF E2RGF3 SLC9A3R1 dog S349 455753 RAHQKRssKRAPQMD EBP50_C X X -PRKCA PKCA P17252 human TfR 7037 P02786 TFRC human S24 451671 PLsytRFsLARQVDG X -PRKCA PKCA P17252 human INSR 3643 P06213 INSR human S1062 451562 AVkTVNEsAsLRERI PK_Tyr_Ser-Thr X -PRKCA PKCA P17252 human Kv3.4 3749 Q03721 KCNC4 human S21 451078 KsGNKPPsKTCLKEE Potassium_chann X -PRKCA PKCA P17252 human Vinculin 396422 P12003 VCL chicken S1114 451252 VREAEAAsIKIRTDA X -PRKCA PKCA P17252 human PLM 58971 O08589 Fxyd1 rat T89 455220 SsIRRLstRRR____ X -PRKCA PKCA P17252 human TRPV1 83810 O35433 Trpv1 rat T704 487542 WKLQRAItILDTEKS X -PRKCA PKCA P17252 human ADCY2 81636 P26769 Adcy2 rat S490 25795203 DGAKMRAsVRMTRYL X -PRKCA PKCA P17252 human AQP2 359 P41181 AQP2 human S256 449854 REVRRRQsVELHsPQ X -PRKCA PKCA P17252 human AMPKA1 5562 Q13131 PRKAA1 human S496 450431 AtPQRsGsVsNyRSC AdenylateSensor X 4185; 4184; 2537 -PRKCA PKCA P17252 human myelin P0 539462 P10522 MPZ cow S210 458930 HKTAKDAsKRGRQTP Myelin-PO_C X -PRKCA PKCA P17252 human AID 11628 Q9WVE0 Aicda mouse S3 20660600 _____MDsLLMKQKK X -PRKCA PKCA P17252 human CACNA1C 100101555 P15381 CACB rabbit S533 453091 RIsKSKFsRYWRRWN X -PRKCA PKCA P17252 human MARCKS 396473 P16527 MARCKS chicken S132 466360 FKKsFKLsGFsFKKN MARCKS X 8722 -PRKCA PKCA P17252 human SHP-2 5781 Q06124 PTPN11 human S576 469622 CAEMREDsARVyENV X -PRKCA PKCA P17252 human PKG1 5592 Q13976 PRKG1 human T59 1870119330 THIGPRTtRAQGIsA X -PRKCA PKCA P17252 human SLC6A2 6530 P23975 SLC6A2 human S259 465614 LWKGVKtsGKVVWIT SNF X -PRKCA PKCA P17252 human NOX5 iso4 79400 Q96PH1-4 NOX5 human T494 472625 KRLsRSVtMRKsQRS FAD_binding_8 X X -PRKCA PKCA P17252 human CaR 846 P41180 CASR human S875 4782110 TIEEVRCsTAAHAFK X -PRKCA PKCA P17252 human mGluR5 iso2 24418 P31424-2 Grm5 rat S901 4213805 QHLWQRLsVHINKKE X X -PRKCA PKCA P17252 human NMDAR1 24408 P35439 Grin1 rat S897 448256 sFKRRRssKDtSTGG X -PRKCA PKCA P17252 human N-CoR1 9611 O75376 NCOR1 human S70 3828921 QQLRRRPsLLsEFHP X -PRKCA PKCA P17252 human EPB41 iso4 2035 P11171-4 EPB41 human S312 455112 QAQTRQAsALIDRPA FA X -PRKCA PKCA P17252 human ADRA1D 146 P25100 ADRA1D human S332 1424270006 KGHtFRssLsVRLLK 7tm_1 X -PRKCA PKCA P17252 human Cortactin 60465 A6HYF4 Cttn rat T145 41425400 GFEYQGktEKHASQK HS1_rep X -PRKCA PKCA P17252 human TNNT2 21956 P50752 Tnnt2 mouse T207 449038 YIQkQAQtERKsGKR Troponin X -PRKCA PKCA P17252 human CACNA1C 100101555 P15381 CACB rabbit S1843 9808101 EAAWKLssKRCHSQE CAC1F_C X -PRKCA PKCA P17252 human p21Cip1 1026 P38936 CDKN1A human S153 456134 sMTDFyHskRrLIFS X X -PRKCA PKCA P17252 human PLM 476487 P56513 FXYD1 dog S83 451424 EEGTFRSsIRRLstR X X -PRKCA PKCA P17252 human NR2C1 22025 Q505F1 Nr2c1 mouse S185 457682 IEVSREKsSNCAAST X -PRKCA PKCA P17252 human CYP2E1 1571 P05181 CYP2E1 human S424 23940008 ENGkFkYsDYFkPFs p450 X -PRKCA PKCA P17252 human SLC1A1 25550 P51907 Slc1a1 rat T5 13204400 ___MGKPtSSGCDWR X -PRKCA PKCA P17252 human GluR1 2890 P42261 GRIA1 human S836 467226 cYKsRsEsKRMKGFC X -PRKCA PKCA P17252 human RIGI 23586 O95786 RIGI human T170 12613700 DkENWPktLkLALEk CARD_2 X X -PRKCA PKCA P17252 human PPAR-alpha 5465 Q07869 PPARA human S179 457549 RFGRMPRsEKAKLkA X -PRKCA PKCA P17252 human TNNI3 7137 P19429 TNNI3 human T143 451483 RGKFKRPtLRrVrIs Troponin X -PRKCA PKCA P17252 human GJA1 24392 P08050 Gja1 rat S372 465460 sRAssRAssRPRPDD X -PRKCA PKCA P17252 human mGluR7 108073 Q68ED2 Grm7 mouse S862 2846504 NVQKRKRsFKAVVTA X -PRKCA PKCA P17252 human RSC1A1 6248 Q92681 RSC1A1 human S366 10433802 LHELLVVsSkPASEN X -PRKCA PKCA P17252 human CENTA1 11033 O75689 ADAP1 human S87 11380900 AARARFEsKVPSFYY ArfGap X -PRKCA PKCA P17252 human PDE5A 281972 Q28156 PDE5A cow S92 448178 GTPTRKIsASEFDRP X -PRKCA PKCA P17252 human NHERF 9368 O14745 NHERF1 human S339 455752 ERAHQKRssKRAPQM EBP50_C X X -PRKCA PKCA P17252 human L-plastin 3936 P13796 LCP1 human S5 450852 ___MARGsVsDEEMM X -PRKCA PKCA P17252 human DAT 24898 P23977 Slc6a3 rat S13 451138 CsVGPMssVVAPAKE X -PRKCA PKCA P17252 human ARHGEF1 9138 Q92888 ARHGEF1 human S240 4936516 TkSGDKKsGRNFFRK X -PRKCA PKCA P17252 human TNNI3 29248 P23693 Tnni3 rat S23 448423 PAPVRRRssANYRAY Troponin-I_N X 4004 -PRKCA PKCA P17252 human neurogranin 4900 Q92686 NRGN human S36 455913 AAAKIQAsFrGHMAR IQ X -PRKCA PKCA P17252 human IRS1 16367 P35569 Irs1 mouse S318 451399 MVGGKPGsFRVRASs X 5610 -PRKCA PKCA P17252 human CYSLTR1 58861 Q99JA4 Cysltr1 mouse T151 27717317 VQNINLVtQKKARFV 7tm_1 X -PRKCA PKCA P17252 human Tau iso8 4137 P10636-8 MAPT human S324 449328 kVtskCGsLGNIHHk Tubulin-binding X -PRKCA PKCA P17252 human Vimentin 7431 P08670 VIM human S8 471087 MStrsVssssyrrMF Filament_head X -PRKCA PKCA P17252 human GSK3A 606496 Q2NL51 Gsk3a mouse S21 448584 sGRARtssFAEPGGG X 9337; 9316; 9331; 9327; 8452; 8566 -PRKCA PKCA P17252 human UGT1A3 54659 P35503 UGT1A3 human S43 34357665 IDGSHWLsMREVLRE UDPGT X -PRKCA PKCA P17252 human Mena iso4 13800 Q03173-4 Enah mouse S236 451465 WERERRMsNAAPSSD X -PRKCA PKCA P17252 human NMDAR2B 2904 Q13224 GRIN2B human S1323 455808 ALAPRSVsLKDKGRF NMDAR2_C X -PRKCA PKCA P17252 human Akt1 24185 P47196 Akt1 rat S473 447855 RPHFPQFsYSASGTA Pkinase_C X 9271; 3787; 4060; 4051; 5102; 4058; 2336; 2337; 4075; 4070; 5012; 4071; 92982; 5315; 9563; 9018; 12694; 52240; 11962; 15116; 88106; 26580; 68035; 31957; 23430; 20235 -PRKCA PKCA P17252 human Titin 22138 A2ASS6 Ttn mouse S12884 4693667 RKkLRPGsGGEKPPD X -PRKCA PKCA P17252 human Lck 3932 P06239 LCK human S42 447819 tLLIRNGsEVRDPLV X -PRKCA PKCA P17252 human Vimentin 7431 P08670 VIM human S9 455450 StrsVssssyrrMFG Filament_head X -PRKCA PKCA P17252 human NCAM-L1 3897 P32004 L1CAM human T1172 4702537 ARPMkDEtFGEyRSL Bravo_FIGEY X -PRKCA PKCA P17252 human Vinculin 396422 P12003 VCL chicken S1102 451251 NAQNLMQsVKETVRE X -PRKCA PKCA P17252 human PLM 476487 P56513 FXYD1 dog S88 451425 RSsIRRLstRRR___ X X -PRKCA PKCA P17252 human RRAD 6236 P55042 RRAD human S290 457397 GRIVARNsRKMAFRA X -PRKCA PKCA P17252 human Caldesmon 373965 P12957 CALD1 chicken S602 457430 CFsPKGSsLKIEERA Caldesmon X -PRKCA PKCA P17252 human PITPNC1 26207 Q9UKF7 PITPNC1 human S274 454503 SVRsAPSsAPstPLs X -PRKCA PKCA P17252 human PR 5241 P06401 PGR human S400 449842 GAEAsARsPRSYLVA Prog_receptor X -PRKCA PKCA P17252 human STXBP1 25558 P61765 Stxbp1 rat S306 448743 VSQEVTRsLkDFSSs Sec1 X -PRKCA PKCA P17252 human PPP1R1A 58977 P19103 Ppp1r1a rat S65 469609 PLLKSTLsMsPRQRK DARPP-32 X X -PRKCA PKCA P17252 human CYP2E1 1571 P05181 CYP2E1 human T387 23940012 GYLIPKGtVVVPTLD p450 X -PRKCA PKCA P17252 human GluR1 50592 P19490 Gria1 rat S849 448565 FCLIPQQsINEAIrT X 75574 -PRKCA PKCA P17252 human MARCKS 4082 P29966 MARCKS human S163 447787 KRFsFkKsFkLsGFs MARCKS X X 2741; 11992 -PRKCA PKCA P17252 human TRPM4 54795 Q8TD43 TRPM4 human S1152 12559512 sERLKRTsQKVDLAL X -PRKCA PKCA P17252 human CELF1 10658 Q92879 CELF1 human T173 29668007 kAMHQAQtMEGCssP RRM_1 X -PRKCA PKCA P17252 human FBXW7 55294 Q969H0 FBXW7 human S10 17337000 QELLSVGsKRRRTGG X -PRKCA PKCA P17252 human JAK2 3717 O60674 JAK2 human S518 56527201 VFRTNGVsDVPtsPT X -PRKCA PKCA P17252 human SLC22A1 24904 Q63089 Slc22a1 rat T550 455614 TIYLQVQtGKSSST_ X -PRKCA PKCA P17252 human Cofilin-1 1072 P23528 CFL1 human S23 9218412 NDMkVRksstPEEVk Cofilin_ADF X X -PRKCA PKCA P17252 human PKCE 5581 Q02156 PRKCE human S234 479975 EtPDQVGsQRFSVNM X -PRKCA PKCA P17252 human CYSLTR1 10800 Q9Y271 CYSLTR1 human S313 11143517 LstFRKHsLssVTYV X -PRKCA PKCA P17252 human SLC38A3 252919 Q9JHZ9 Slc38a3 rat S52 19001700 KGFLQQSsSKEPHFT X -PRKCA PKCA P17252 human IGFBP1 3484 P08833 IGFBP1 human S126 451658 GsPEsPEstEITEEE X -PRKCA PKCA P17252 human GLT1 29482 P31596 Slc1a2 rat S563 486052 NGksADCsVEEEPWk X -PRKCA PKCA P17252 human CELF1 10658 Q92879 CELF1 human S302 3347301 TSSGSsPsSSSSNSV X -PRKCA PKCA P17252 human MBP 618684 P02687 MBP cow S109 451768 QGKGrGLsLSRFsWG Myelin_MBP X -PRKCA PKCA P17252 human PIP5K1B 18719 P70181 Pip5k1b mouse S413 27461455 PSKKRCNsIAALKAT X X -PRKCA PKCA P17252 human GPR120 iso1 338557 Q5NUL3-1 FFAR4 human S366 31014808 GAILtDtsVKRNDLs X -PRKCA PKCA P17252 human ROMK 3758 P48048 KCNJ1 human S4 2813507 ____MNAsSRNVFDT X -PRKCA PKCA P17252 human IGFBP1 3484 P08833 IGFBP1 human S123 4668105 AEAGsPEsPEstEIT X -PRKCA PKCA P17252 human CaR 846 P41180 CASR human T888 449862 FKVAARAtLRRsNVs X X -PRKCA PKCA P17252 human DOCK8 81704 Q8NF50 DOCK8 human S2082 3929310 VEsQKRDsFHRSsFR X -PRKCA PKCA P17252 human NFkB-p65 5970 Q04206 RELA human S536 447800 sGDEDFSsIADMDFS X 4887; 3036; 3031; 4886; 3033; 4025; 5733; 13346; 76778; 31553; 80477; 73992; 87672; 83962 -PRKCA PKCA P17252 human NOXO1 iso3 124056 Q8NFA2-3 NOXO1 human T341 28758706 AIQSRCCtVTRRALE X X -PRKCA PKCA P17252 human CHAT iso3 1103 P28329-3 CHAT human S440 449057 VPTYESAsIRRFQEG Carn_acyltransf X -PRKCA PKCA P17252 human BAP37 11331 Q99623 PHB2 human S39 1868188300 VAyGVREsVFTVEGG X X -PRKCA PKCA P17252 human FBXW7 55294 Q969H0 FBXW7 human S18 17337001 KRRRTGGsLRGNPSs X X -PRKCA PKCA P17252 human PLD2 5338 O14939 PLD2 human T252 456498 LLYMCLEtGAISFVQ X -PRKCA PKCA P17252 human GJA1 24392 P08050 Gja1 rat S365 459207 IVDQRPssRAssRAs X -PRKCA PKCA P17252 human MBP 618684 P02687 MBP cow S150 487420 HDAQGtLsKIFKLGG Myelin_MBP X -PRKCA PKCA P17252 human MARCKS 613548 P12624 MARCKS cow S169 451837 sFKLsGFsFKKNKKE MARCKS X 8722 -PRKCA PKCA P17252 human ADCY6 25289 Q03343 Adcy6 rat S674 455529 EDLEKKYsRKVDPRF Adcy_cons_dom X -PRKCA PKCA P17252 human TXA2-R 6915 P21731 TBXA2R human S331 470029 sTRPRsLsLQPQLtQ X -PRKCA PKCA P17252 human ANXA5 iso2 AAB24204 ANXA5 cow T22 2358301 DERADAEtLRKAMKG Annexin X -PRKCA PKCA P17252 human NMDAR2B 2904 Q13224 GRIN2B human S1415 1874095504 QPtVAGAsKARPDFR NMDAR2_C X -PRKCA PKCA P17252 human TRPV1 83810 O35433 Trpv1 rat T144 456216 QRSKKRLtDSEFKDP Ank_2 X -PRKCA PKCA P17252 human GluR6 2898 Q13002 GRIK2 human S868 478417 MVEELRMsLKcQRRL X -PRKCA PKCA P17252 human GSK3B 56637 Q9WV60 Gsk3b mouse S9 449111 SGRPRttsFAEsCKP X X 9336; 9331; 9327; 9323; 9322; 9325; 5558; 8566; 79774; 8466; 25462; 14026; 14332; 14310; 14630 -PRKCA PKCA P17252 human TAUT 404000 Q00589 SLC6A6 dog S322 450688 YNKYKYNsYRDCMLL SNF X X -PRKCA PKCA P17252 human SLC6A12 404013 P27799 SLC6A12 dog T40 33673901 VKDRGQWtNKMEFVL SNF X -PRKCA PKCA P17252 human eNOS 287024 P29473 NOS3 cow T497 447885 AGITRKktFKEVANA X -PRKCA PKCA P17252 human LRP1 4035 Q07954 LRP1 human T4460 12526700 GFQHQRMtNGAMNVE X X -PRKCA PKCA P17252 human TNNI3 511094 P08057 TNNI3 cow S46 450691 KKSKIsAsRKLQLKT X -PRKCA PKCA P17252 human hnRNP A1 29578 P04256 Hnrnpa1 rat S223 2874412 FGrGGNFsGrGGFGG X -PRKCA PKCA P17252 human SSTR2 P30680 Sstr2 rat S343 7652105 EDGERsDsKQDKsRL X -PRKCA PKCA P17252 human NR1H4 iso2 9971 Q96RI1-2 NR1H4 human S154 4245800 CKGFFRRsITKNAVY zf-C4 X X -PRKCA PKCA P17252 human C5aR 728 P21730 C5AR1 human S332 448822 EEsVVREsKsFTRsT X -PRKCA PKCA P17252 human NLGN4X 57502 Q8N0W4 NLGN4X human T707 40245512 KDKRRHEtHRRPSPQ X X -PRKCA PKCA P17252 human RhoGDI alpha 396 P52565 ARHGDIA human S96 486318 DLtGDLEsFKkQsFV Rho_GDI X X -PRKCA PKCA P17252 human HSP27 3315 P04792 HSPB1 human S15 448401 FsLLrGPsWDPFrDW X 2404 -PRKCA PKCA P17252 human ARRB1 408 P49407 ARRB1 human S163 31894300 EkIHKRNsVRLVIRK Arrestin_N X X -PRKCA PKCA P17252 human DAT 24898 P23977 Slc6a3 rat S7 451136 _MsKsKCsVGPMssV X -PRKCA PKCA P17252 human CYSLTR1 58861 Q99JA4 Cysltr1 mouse T323 11143513 NFRRRLStFRKHSLs X -PRKCA PKCA P17252 human TNNI3 7137 P19429 TNNI3 human S44 450691 KKskIsAsRKLQLKt X -PRKCA PKCA P17252 human LRP1 4035 Q07954 LRP1 human S4517 4769100 LyMGGHGsRHsLAsT X X -PRKCA PKCA P17252 human myelin P0 539462 P10522 MPZ cow S233 458933 SRSTKAAsEKKTKGL Myelin-PO_C X -PRKCA PKCA P17252 human TXA2-R 6915 P21731 TBXA2R human S324 3061802 RRLQPRLsTRPRsLs X -PRKCA PKCA P17252 human CHAT iso3 1103 P28329-3 CHAT human S347 454036 LKHVTQssRKLIRAD Carn_acyltransf X -PRKCA PKCA P17252 human MARCKS 396473 P16527 MARCKS chicken S135 451837 sFKLsGFsFKKNKKE MARCKS X 8722 -PRKCA PKCA P17252 human CYP3A4 1576 P08684 CYP3A4 human S116 8084159 GPVGFMksAIsIAED p450 X -PRKCA PKCA P17252 human TXA2-R 6915 P21731 TBXA2R human S329 450989 RLsTRPRsLsLQPQL X -PRKCA PKCA P17252 human DTNB 1838 O60941 DTNB human T212 27100603 MLNMFLDtMMADPPP EF-hand_3 X -PRKCA PKCA P17252 human CK1D 1453 P48730 CSNK1D human S298 1871153003 NMLKFGAsRAADDAE X -PRKCA PKCA P17252 human coronin 1A 11151 P31146 CORO1A human T412 3995219 RVNRGLDtGRRRAAP Trimer_CC X X -PRKCA PKCA P17252 human CHAT iso3 1103 P28329-3 CHAT human T255 454038 TVLVKDStNRDSLDM Carn_acyltransf X -PRKCA PKCA P17252 human p47phox 653361 P14598 NCF1 human S370 451730 PAVPPRPsADLILNR p47_phox_C X -PRKCA PKCA P17252 human ASIC3 286920 O35240 Asic3 rat T40 12518704 IFGPGGLtLRRGLWA TM; ASC X -PRKCA PKCA P17252 human NPHS1 4868 O60500 NPHS1 human T1125 18507017 QWtGERDtQSSTVST X X -PRKCA PKCA P17252 human GluR5 29559 P22756 Grik1 rat S923 457626 QKKLKKKsRTKGKsS X -PRKCA PKCA P17252 human PFKFB3 5209 Q16875 PFKFB3 human S461 448801 NPLMRRNsVtPLAsP X -PRKCA PKCA P17252 human LSD1 99982 Q6ZQ88 Kdm1a mouse S112 3828907 TPEGRRTsRRKRAKV X X -PRKCA PKCA P17252 human SCN2A 24766 P04775 Scn2a rat S576 2999206 PrRNsRAsLFNFKGR Na_trans_cytopl X -PRKCA PKCA P17252 human RRAD 6236 P55042 RRAD human S299 457398 KMAFRAKsKsCHDLS X -PRKCA PKCA P17252 human eIF2-gamma 1968 P41091 EIF2S3 human T66 21514202 kAISGVHtVRFkNEL GTP_EFTU X -PRKCA PKCA P17252 human CYP3A4 1576 P08684 CYP3A4 human T284 22553307 DSQNSkEtESHKALS p450 X -PRKCA PKCA P17252 human ITGB2 3689 P05107 ITGB2 human T760 450185 LFksAtttVMNPkFA Integrin_b_cyt X -PRKCA PKCA P17252 human MKLN1 27418 O89050 Mkln1 mouse T515 474505 MVPMTGFtQRATIDP X -PRKCA PKCA P17252 human CACNA1B 257648 Q02294 Cacna1b rat S774 455280 SVWEQRAsQLRLQNL X -PRKCA PKCA P17252 human KCNMA1 3778 Q12791 KCNMA1 human S1200 9805700 SHSsQSSsKKSSsVH X -PRKCA PKCA P17252 human ITGB4 3691 P16144 ITGB4 human S1364 451655 PSGsQRPsVSDDTGC X -PRKCA PKCA P17252 human Titin 22138 A2ASS6 Ttn mouse S12742 10029600 KEEVVLksVLRKKPE X -PRKCA PKCA P17252 human TRPV1 7442 Q8NER1 TRPV1 human S502 450016 YFLQRRPsMKTLFVD Ion_trans X -PRKCA PKCA P17252 human mGluR5 24418 P31424 Grm5 rat S839 455778 VRSAFTTstVVRMHV X -PRKCA PKCA P17252 human TNNT2 286816 P13789 TNNT2 cow T200 451556 RKsGKRQtEREKKKK Troponin X -PRKCA PKCA P17252 human PTPN22 26191 Q9Y2R2 PTPN22 human S751 5963554 kSFtRSKsLKILRNM X X -PRKCA PKCA P17252 human Tau iso8 4137 P10636-8 MAPT human S293 449327 NVQskCGsKDNIkHV Tubulin-binding X -PRKCA PKCA P17252 human CYP2E1 1571 P05181 CYP2E1 human S431 23940014 sDYFkPFstGkRVCA p450 X -PRKCA PKCA P17252 human GluR6 14806 P39087 Grik2 mouse S846 11496000 VGEFLYKsKKNAQLE X X -PRKCA PKCA P17252 human MBP 618684 P02687 MBP cow S131 451769 FGYGGRAsDYKSAHK Myelin_MBP X -PRKCA PKCA P17252 human PPP1R14A 397610 O18734 PPP1R14A pig T38 449098 QKRHARVtVKYDRRE PP1_inhibitor X -PRKCA PKCA P17252 human TRPM2 iso3 7226 O94759-3 TRPM2 human S39 30312508 NLRRSNSsLFKSWRL X -PRKCA PKCA P17252 human CELF1 10658 Q92879 CELF1 human S300 29668005 VLTSSGSsPsSSSSN X -PRKCA PKCA P17252 human SH2-B-beta 25970 Q9NRF2 SH2B1 human S165 21336501 VGRsVRGsVRGILQW X -PRKCA PKCA P17252 human TXA2-R 6915 P21731 TBXA2R human T337 451395 LsLQPQLtQRSGLQ_ X -PRKCA PKCA P17252 human PPP1R1A 5502 Q13522 PPP1R1A human T75 471085 PRQRKKMtRItPTMK DARPP-32 X -PRKCA PKCA P17252 human TNNI3 511094 P08057 TNNI3 cow S79 451839 GEKGRALsTRCQPLE Troponin X -PRKCA PKCA P17252 human TNNI3 7137 P19429 TNNI3 human S42 450690 AKKKskIsAsRKLQL X -PRKCA PKCA P17252 human Bcl-11B 64919 Q9C0K0 BCL11B human S2 55578701 ______MsRRKQGNP X -PRKCA PKCA P17252 human SLC29A1 63959 Q9JIM1 Slc29a1 mouse S288 21326707 sIKAILKsICVPALS Nucleoside_tran X -PRKCA PKCA P17252 human Kit 3815 P10721 KIT human S746 450036 RRsVRIGsyIERDVT PK_Tyr_Ser-Thr X -PRKCA PKCA P17252 human THOP1 64517 P24155 Thop1 rat S644 448213 VGMDYRTsILRPGGS Peptidase_M3 X -PRKCA PKCA P17252 human MYBPC1 iso2 109272 G0YZM8 Mybpc1 mouse T84 21560211 NANSQLstLFVEKPQ I-set X -PRKCA PKCA P17252 human ADD1 11518 Q9QYC0 Add1 mouse S724 449829 KKKFRtPsFLKKSKK X -PRKCA PKCA P17252 human NR2C1 22025 Q505F1 Nr2c1 mouse S568 456552 IGNVRIDsVIPHILK X -PRKCA PKCA P17252 human p47phox 653361 P14598 NCF1 human S304 449406 GAPPRRssIRNAHsI NECFESHC X -PRKCA PKCA P17252 human AQP1 358 P29972 AQP1 human T239 482807 APRSsDLtDRVKVWT X X -PRKCA PKCA P17252 human MKLN1 27418 O89050 Mkln1 mouse S324 474504 TEKENGPsARSCHKM Kelch_3 X -PRKCA PKCA P17252 human C5aR 728 P21730 C5AR1 human S327 448821 RNVLtEEsVVREsKs X -PRKCA PKCA P17252 human SLC22A1 24904 Q63089 Slc22a1 rat S292 455611 EsPRWLLsQKRtTRA Sugar_tr X -PRKCA PKCA P17252 human CYP1A1 13076 P00184 Cyp1a1 mouse T35 471065 WVVRATRtWVPKGLK X -PRKCA PKCA P17252 human basonuclin 1 646 Q01954 BNC1 human S541 451420 KKksRKSsMPIkIEK X -PRKCA PKCA P17252 human LRRK1 79705 Q38SD2 LRRK1 human S1064 15411924 NRKVTIysFTGNQRN X -PRKCA PKCA P17252 human myelin P0 539462 P10522 MPZ cow S243 458935 KTKGLGEsRKDKK__ Myelin-PO_C X -PRKCA PKCA P17252 human H1R 3269 P35367 HRH1 human S396 453404 FTWKRLRsHsRQyVS 7tm_1 X -PRKCA PKCA P17252 human MMP2 4313 P08253 MMP2 human S160 479858 DVTPLRFsRIHDGEA Peptidase_M10 X -PRKCA PKCA P17252 human CK1D 64462 Q06486 Csnk1d rat T392 53356804 DLTGRQDtsRMstsQ X -PRKCA PKCA P17252 human K20 54474 P35900 KRT20 human S13 463823 RSFHRsLsSSLQAPV X 39359 -PRKCA PKCA P17252 human TUBA1A 7846 Q71U36 TUBA1A human S165 25757493 sVDyGkkskLEFSIy Tubulin X -PRKCA PKCA P17252 human RORA 6095 P35398 RORA human S100 1212279800 CKGFFRRsQQSNATY zf-C4 X -PRKCA PKCA P17252 human ANXA2 282689 P04272 ANXA2 cow S26 450879 TPPSAyGsVKAYTNF X X -PRKCA PKCA P17252 human PRKD2 25865 Q9BZL6 PRKD2 human S706 449864 ARIIGEksFRRsVVG Pkinase X -PRKCA PKCA P17252 human Kv4.2 Q63881 Kcnd2 rat S537 4668100 CSRRHKKsFRIPNAN DUF3399 X X -PRKCA PKCA P17252 human ADCY6 25289 Q03343 Adcy6 rat S568 455528 TFLILGAsQKRKEEK X -PRKCA PKCA P17252 human AR 11835 P19091 Ar mouse S794 1875398900 MKALLLFsIIPVDGL Hormone_recep X -PRKCA PKCA P17252 human Kir6.2 16514 Q61743 Kcnj11 mouse S372 22874702 RGPLRKRsVAVAKAK X -PRKCA PKCA P17252 human PRKD1 5587 Q15139 PRKD1 human S412 20615903 PLMRVVQsVKHTKRK X -PRKCA PKCA P17252 human PRKD2 25865 Q9BZL6 PRKD2 human S710 449865 GEksFRRsVVGtPAy Pkinase X -PRKCA PKCA P17252 human NMDAR1 24408 P35439 Grin1 rat S890 447737 ITSTLAssFKRRRss X -PRKCA PKCA P17252 human pleckstrin 5341 P08567 PLEK human S117 451306 ARKstRRsIRLPEtI X X -PRKCA PKCA P17252 human MBP 618684 P02687 MBP cow S10 456424 QKRPsQRsKYLASAs X -PRKCA PKCA P17252 human EWS 2130 Q01844 EWSR1 human S266 448028 SSYGQQSsFRQDHPS X -PRKCA PKCA P17252 human DNAM-1 10666 Q15762 CD226 human S329 450987 yVNyPTFsRRPKTRV X -PRKCA PKCA P17252 human GSK3A 2931 P49840 GSK3A human S21 448584 sGrARtssFAEPGGG X X 9337; 9316; 9331; 5090; 9327; 8452; 8566 -PRKCA PKCA P17252 human DAT 6531 Q01959 SLC6A3 human S12 451137 kCsVGLMssVVAPAK X -PRKCA PKCA P17252 human GAP43 29423 P07936 Gap43 rat S41 448719 AATkIQAsFRGHITR IQ X -PRKCA PKCA P17252 human ARX 170302 Q96QS3 ARX human S174 1297351802 VSISRSKsYRENGAP X -PRKCA PKCA P17252 human ZFP64 55734 Q9NTW7 ZFP64 human S226 7322830 NKHLRIHsDERPFKC zf-H2C2_5 X X -PRKCA PKCA P17252 human GRF-1 2909 Q9NRY4 ARHGAP35 human S1221 10406116 RRRNILRsLRRNtKK RhoGAP_pG1_pG2 X -PRKCA PKCA P17252 human TRPV1 83810 O35433 Trpv1 rat S800 450017 VPLLRDAsTRDRHAT X X -PRKCA PKCA P17252 human PODXL 192181 Q9WTQ2 Podxl rat S415 21514209 GCCHQRIsQRKDQQR CD34_antigen X -PRKCA PKCA P17252 human ANXA2 302 P07355 ANXA2 human S12 450880 HEILCkLsLEGDHst X -PRKCA PKCA P17252 human ADRA1D 146 P25100 ADRA1D human S300 1424270001 KRERGKAsEVVLRIH 7tm_1 X -PRKCA PKCA P17252 human DOR-1 18386 P32300 Oprd1 mouse S344 448552 CGRQEPGsLRRPRQA X -PRKCA PKCA P17252 human RAB37 326624 Q96AX2 RAB37 human T172 556476901 YGVPFLEtSAKTGMN Ras X -PRKCA PKCA P17252 human KCNJ8 25472 Q63664 Kcnj8 rat S379 1458601 SELSHQNsLRKRNsM X -PRKCA PKCA P17252 human p47phox 653361 P14598 NCF1 human S379 451498 DLILNRCsEstKRKL p47_phox_C X -PRKCA PKCA P17252 human FRAT1 10023 Q92837 FRAT1 human S188 471366 RLQQRRGsQPETRTG GSK-3_bind X -PRKCA PKCA P17252 human LRRK1 79705 Q38SD2 LRRK1 human T1075 1879806800 NQRNRCstFRVKRNQ X -PRKCA PKCA P17252 human MRLC1 10398 P24844 MYL9 human S3 4964100 _____MssKRAKAKt X -PRKCA PKCA P17252 human APLP2 334 Q06481 APLP2 human T723 11500600 LRKRQYGtISHGIVE APP_amyloid X -PRKCA PKCA P17252 human GHSR 2693 Q92847 GHSR human T261 25293461 RDQNHKQtVKMLAVV 7tm_1 X -PRKCA PKCA P17252 human H1R 3269 P35367 HRH1 human T478 453403 CNENFKKtFKRILHI X -PRKCA PKCA P17252 human AT2 24182 P35351 Agtr2 rat S354 469106 MsCRKSSsLREMDTF X -PRKCA PKCA P17252 human GluR-delta2 14804 Q61625 Grid2 mouse S945 3595502 QTLSRTLsAkAASGF X -PRKCA PKCA P17252 human IRS1 25467 P35570 Irs1 rat S612 447562 DDGyMPMsPGVAPVP X 3193; 2386; 3203 -PRKCA PKCA P17252 human MARCKS 4082 P29966 MARCKS human S159 447786 kkKKKRFsFkKsFkL MARCKS X X 2741; 11992 -PRKCA PKCA P17252 human CELF1 10658 Q92879 CELF1 human S241 29668004 LLQQTASsGNLNTLS X -PRKCA PKCA P17252 human NMDAR1 24408 P35439 Grin1 rat S896 448255 ssFKRRRssKDtSTG X -PRKCA PKCA P17252 human ATP1A1 24211 P06685 Atp1a1 rat S23 449087 sEHGDkkskkAKKER X 4006 -PRKCA PKCA P17252 human CYP2E1 1571 P05181 CYP2E1 human S129 455561 WKDIRRFsLttLRNY p450 X -PRKCA PKCA P17252 human NOX5 iso4 79400 Q96PH1-4 NOX5 human S498 472626 RSVtMRKsQRSsKGS FAD_binding_8 X X -PRKCA PKCA P17252 human TAGLN2 8407 P37802 TAGLN2 human S185 1983445 MGtNrGAsQAGMtGy Calponin X -PRKCA PKCA P17252 human BEST1 7439 O76090 BEST1 human S358 9720901 SAQFRRAsFMGSTFN X -PRKCA PKCA P17252 human ephexin-5 442801 Q5FWH6 Arhgef15 mouse S107 17546056 PSPVSRRsIsPEPAP X X -PRKCA PKCA P17252 human HNF4 alpha 25735 P22449 Hnf4a rat S87 478421 CKGFFRRsVRKNHMY zf-C4 X -PRKCA PKCA P17252 human ITGB4 3691 P16144 ITGB4 human S1360 451654 VLRsPSGsQRPsVSD X X -PRKCA PKCA P17252 human TRPV1 7442 Q8NER1 TRPV1 human S801 450017 VPLLREAsARDRQsA X -PRKCA PKCA P17252 human CYP3A4 1576 P08684 CYP3A4 human T92 22553302 TDPDMIKtVLVKECY p450 X -PRKCA PKCA P17252 human GluR6 14806 P39087 Grik2 mouse S868 478417 MVEELRMsLKCQRRL X X -PRKCA PKCA P17252 human MRLC1 10398 P24844 MYL9 human T10 4964102 sKRAKAKttKKRPQR X X -PRKCA PKCA P17252 human GAP43 281777 P06836 GAP43 cow S41 448719 AATKIQAsFRGHITR IQ X -PRKCA PKCA P17252 human CYP2E1 1571 P05181 CYP2E1 human T58 23940004 KNIPKsFtRLAQRFG p450 X -PRKCA PKCA P17252 human NHERF 26941 P70441 Nherf1 mouse S77 957200 ETHQQVVsRIRAALN PDZ X -PRKCA PKCA P17252 human hnRNP A1 29578 P04256 Hnrnpa1 rat S199 451555 sQRGRsGsGNFGGGr X -PRKCA PKCA P17252 human MARCKS 396473 P16527 MARCKS chicken S128 447787 KRFsFKKsFKLsGFs MARCKS X 11992 -PRKCA PKCA P17252 human DTNB 1838 O60941 DTNB human T179 27100601 KEVLKLPtAVFEGPS EF-hand_3 X -PRKCA PKCA P17252 human APPL 26060 Q9UKG1 APPL1 human S430 13204434 ARTSssGsLGSESTN X -PRKCA PKCA P17252 human HER2 2064 P04626 ERBB2 human T686 451817 QQKIRKYtMRRLLQE X 88583 -PRKCA PKCA P17252 human TNNT2 21956 P50752 Tnnt2 mouse S288 457603 INDNQkVsKTRGKAK Troponin X -PRKCA PKCA P17252 human Claudin-4 1364 O14493 CLDN4 human S194 4199301 PRTDKPysAKysAAR X -PRKCA PKCA P17252 human MMP2 4313 P08253 MMP2 human T378 479861 GKMWCAttANYDDDR Peptidase_M10; fn2 X -PRKCA PKCA P17252 human GluR5 29559 P22756 Grik1 rat S929 457627 KsRTKGKsSFTSILT X -PRKCA PKCA P17252 human LRP1 4035 Q07954 LRP1 human S4520 450168 GGHGsRHsLAsTDEk X X -PRKCA PKCA P17252 human ATP4A 397552 P19156 ATP4A pig S27 3189202 GDMAAKMsKKKAGRG H-K_ATPase_N X -PRKCA PKCA P17252 human SLC22A1 24904 Q63089 Slc22a1 rat T296 455612 WLLsQKRtTRAVRIM Sugar_tr X -PRKCA PKCA P17252 human TNNI3 511094 P08057 TNNI3 cow S24 448423 PPPVRRRssANYRAY Troponin-I_N X -PRKCA PKCA P17252 human TNNI3 7137 P19429 TNNI3 human S199 4707844 RkNIDALsGMEGRKK X -PRKCA PKCA P17252 human KCC2 171373 Q63633 Slc12a5 rat S963 487533 ITDESRGsIRRKNPA SLC12 X X -PRKCA PKCA P17252 human ABCB1 5243 P08183 ABCB1 human S661 456983 SSNDSRSsLIRKRsT X -PRKCA PKCA P17252 human Src 396442 P00523 SRC chicken S12 448230 KSKPKDPsQRRRsLE X X -PRKCA PKCA P17252 human Cortactin 60465 A6HYF4 Cttn rat S135 31881968 QMDRVDQsAVGFEYQ HS1_rep X -PRKCA PKCA P17252 human TRPV1 83810 O35433 Trpv1 rat S502 450016 YFLQRRPsLKSLFVD Ion_trans X X -PRKCA PKCA P17252 human NR1H4 iso2 9971 Q96RI1-2 NR1H4 human S135 4245801 VVCGDRAsGYHYNAL zf-C4 X X -PRKCA PKCA P17252 human AKAP12 83425 Q5QD51 Akap12 rat S515 469988 SsGLKKLsGKKQKGK X -PRKCA PKCA P17252 human TRPV1 83810 O35433 Trpv1 rat S774 456217 EGVKRTLsFSLRSGR X -PRKCA PKCA P17252 human DYNC1I2 116659 Q62871 Dync1i2 rat S89 3195347 VPPPMSPssKSVstP X -PRKCA PKCA P17252 human MBD4 8930 O95243 MBD4 human S262 22730000 sGFVQSDsKRESVCN X -PRKCA PKCA P17252 human ROMK 3758 P48048 KCNJ1 human S201 2813508 FSKNAVIskRGGKLC IRK_C X -PRKCA PKCA P17252 human Tau iso8 4137 P10636-8 MAPT human S258 487453 PDLkNVKskIGstEN Tubulin-binding X -PRKCA PKCA P17252 human ABCB1 5243 P08183 ABCB1 human S667 455363 SsLIRKRsTRRsVRG X -PRKCA PKCA P17252 human Cofilin-1 1072 P23528 CFL1 human S24 9218418 DMkVRksstPEEVkk Cofilin_ADF X X -PRKCA PKCA P17252 human NHERF 9368 O14745 NHERF1 human S162 450312 CtMKKGPsGyGFNLH PDZ X -PRKCA PKCA P17252 human p53 7157 P04637 TP53 human T377 3309800 kskkGQstsRHkkLM X -PRKCA PKCA P17252 human PANX1 24145 Q96RD7 PANX1 human Y199 462886 KYPIVEQyLkTkkNS Innexin X -PRKCA PKCA P17252 human SNAP-25 6616 P60880 SNAP25 human S187 448668 RIMEKADsNKTRIDE X X -PRKCA PKCA P17252 human ANXA1 301 P04083 ANXA1 human S27 447972 EyVQtVksskGGPGs X -PRKCA PKCA P17252 human DOCK8 81704 Q8NF50 DOCK8 human S2087 4041179 RDsFHRSsFRKCETQ X -PRKCA PKCA P17252 human RALBP1 10928 Q15311 RALBP1 human S353 3136102 LSPTVQIsNRVLYVF RhoGAP X -PRKCA PKCA P17252 human CYP3A4 1576 P08684 CYP3A4 human S139 15499923 LLsPtFTsGKLKEMV p450 X -PRKCA PKCA P17252 human PAK5 57144 Q9P286 PAK5 human S99 29574070 ISVTRSNsLRKESPP X -PRKCA PKCA P17252 human cytohesin 2 9266 Q99418 CYTH2 human S392 450661 AARKKRIsVKKKQEQ X -PRKCA PKCA P17252 human ATF-2 1386 P15336 ATF2 human S121 6406001 LAtPIIRsKIEEPSV X -PRKCA PKCA P17252 human CTNND1 1500 O60716 CTNND1 human S879 450459 LIDRNQksDkkPDRE X -PRKCA PKCA P17252 human PICK1 84591 Q9EP80 Pick1 rat S77 23045800 ITGVNGRsIKGKtKV PDZ X -PRKCA PKCA P17252 human MARCKS 613548 P12624 MARCKS cow S166 466360 FKKsFKLsGFsFKKN MARCKS X 8722 -PRKCA PKCA P17252 human profilin 1 513895 P02584 PFN1 cow S138 2850008 MASHLRRsQY_____ Profilin X -PRKCA PKCA P17252 human MBD4 8930 O95243 MBD4 human S165 22730001 CSMAALTsHLQNQSN X -PRKCA PKCA P17252 human HOXA9 15405 P09631 Hoxa9 mouse T205 2906101 NWLHARstRKKRCPY X -PRKCA PKCA P17252 human CYP2E1 1571 P05181 CYP2E1 human S74 23940006 VFtLYVGsQRMVVMH p450 X -PRKCA PKCA P17252 human KIR3DL1 3811 P43629 KIR3DL1 human S415 990302 QRKITRPsQRPKtPP X -PRKCA PKCA P17252 human MARCKS 4082 P29966 MARCKS human S167 466360 FkKsFkLsGFsFkKN MARCKS X 8722 -PRKCA PKCA P17252 human CACNA1C 12288 Q01815 Cacna1c mouse S1897 455278 ASLGRRAsFHLECLK CAC1F_C X -PRKCA PKCA P17252 human PDE3A 5139 Q14432 PDE3A human S292 471415 VFkRRRRsssVVsAE X -PRKCA PKCA P17252 human CD36 948 P16671 CD36 human T92 23017300 VKQRGPYtYRVRFLA CD36 X -PRKCA PKCA P17252 human p53 7157 P04637 TP53 human S371 447533 AHssHLkskkGQsts X -PRKCA PKCA P17252 human Titin 7273 Q8WZ42 TTN human S12022 4693667 RRKLRPGsGGEKPPD X -PRKCA PKCA P17252 human GSK3B 2932 P49841 GSK3B human S9 449111 SGRPRttsFAEsCkP X X 9336; 9331; 9327; 9323; 9322; 9325; 5558; 8566; 79774; 8466; 25462; 14026; 14332; 14310; 14630 -PRKCA PKCA P17252 human LRRK1 79705 Q38SD2 LRRK1 human S1074 1879806802 GNQRNRCstFRVKRN X -PRKCA PKCA P17252 human PLM 5348 O00168 FXYD1 human S88 451425 RssIRRLstRRR___ X -PRKCA PKCA P17252 human fascin 6624 Q16658 FSCN1 human S39 450888 KVNASAssLkkkQIW Fascin X X -PRKCA PKCA P17252 human VTN 7448 P04004 VTN human S386 452176 YRsQRGHsRGRNQNs X -PRKCA PKCA P17252 human PPP1R1A 58977 P19103 Ppp1r1a rat S67 447758 LKSTLsMsPRQRKKM DARPP-32 X -PRKCA PKCA P17252 human HuR 1994 Q15717 ELAVL1 human S221 478357 QAQrFrFsPMGVDHM X -PRKCA PKCA P17252 human TACSTD2 4070 P09758 TACSTD2 human S322 470219 GELRkEPsL______ X -PRKCA PKCA P17252 human RALBP1 10928 Q15311 RALBP1 human S509 3136100 FLRRQIAsEKEEIER X -PRKCA PKCA P17252 human Ebp1 5036 Q9UQ80 PA2G4 human S360 478276 ELkALLQssAsRKtQ X -PRKCA PKCA P17252 human NF1 iso2 4763 P21359-2 NF1 human S2808 456895 QKQRSAGsFKRNsIK X -PRKCA PKCA P17252 human SNAP-25 25012 P60881 Snap25 rat S187 448668 RIMEkADsNkTRIDE X -PRKCA PKCA P17252 human RKIP 5037 P30086 PEBP1 human S153 448755 RGKFkVAsFRKKYEL PBP X -PRKCA PKCA P17252 human DYN1 1759 Q05193 DNM1 human S778 450206 GRRsPtssPtPQRRA X -PRKCA PKCA P17252 human RAF1 5894 P04049 RAF1 human S499 450237 VksRWsGsQQVEQPT PK_Tyr_Ser-Thr X X -PRKCA PKCA P17252 human C5aR 728 P21730 C5AR1 human S338 448820 EsKsFTRsTVDTMAQ X -PRKCA PKCA P17252 human PRKD3 23683 O94806 PRKD3 human S731 456755 ARIIGEksFRRsVVG Pkinase X -PRKCA PKCA P17252 human AR 367 P10275 AR human S579 4275600 YGALTCGsCKVFFKR zf-C4 X X -PRKCA PKCA P17252 human PTPRA 19262 P18052 Ptpra mouse S204 447612 PLLARsPstNRKYPP X -PRKCA PKCA P17252 human PDE3A 5139 Q14432 PDE3A human S428 456821 IPKRLRRsLPPGLLR X X -PRKCA PKCA P17252 human CYP2E1 1571 P05181 CYP2E1 human T132 23940010 IRRFsLttLRNYGMG p450 X -PRKCA PKCA P17252 human Bcl-2 596 P10415 BCL2 human S70 448395 RDPVARtsPLQtPAA X X 2834; 2827 -PRKCA PKCA P17252 human TRPM2 28240 Q91YD4 Trpm2 mouse T738 1879806400 GGIQAFLtKVWWGQL X -PRKCA PKCA P17252 human PLM 58971 O08589 Fxyd1 rat S83 451424 EEGtFRSsIRRLstR X -PRKCA PKCA P17252 human CELF1 10658 Q92879 CELF1 human S52 25733984 INVLRDRsQNPPQSk RRM_1 X -PRKCA PKCA P17252 human PACSIN2 11252 Q9UNF0 PACSIN2 human S313 4786393 ADLNRtLsRREKKKA X -PRKCA PKCA P17252 human JAM-A 50848 Q9Y624 F11R human S284 467829 kVIysQPsARsEGEF X X -PRKCA PKCA P17252 human ABCB1 5243 P08183 ABCB1 human S671 455365 RKRsTRRsVRGsQAQ X -PRKCA PKCA P17252 human ADRA1D 146 P25100 ADRA1D human S323 1424270002 DGAHGMRsAKGHtFR 7tm_1 X -PRKCA PKCA P17252 human hnRNP A1 29578 P04256 Hnrnpa1 rat T103 2874414 QRPGAHLtVKKIFVG X -PRKCA PKCA P17252 human CYP3A4 1576 P08684 CYP3A4 human T136 22553304 LRsLLsPtFTsGKLK p450 X -PRKCA PKCA P17252 human P70S6KB 6199 Q9UBS0 RPS6KB2 human S473 450071 PPSGTKKsKRGRGRP X X -PRKCA PKCA P17252 human SATB1 6304 Q01826 SATB1 human S185 464645 DLPPEQWsHTtVRNA CUTL X X -PRKCA PKCA P17252 human CD4 920 P01730 CD4 human S433 451188 RRQAERMsQIkRLLs Tcell_CD4_C X -PRKCA PKCA P17252 human PLM 58971 O08589 Fxyd1 rat S88 451425 RSsIRRLstRRR___ X -PRKCA PKCA P17252 human PTP-PEST 5782 Q05209 PTPN12 human S39 451311 FMRLRRLstKYRTEK X X -PRKCA PKCA P17252 human IREB1 48 P21399 ACO1 human S711 455225 REFNSYGsRrGNDAV Aconitase_C X -PRKCA PKCA P17252 human TXA2-R 6915 P21731 TBXA2R human S145 469630 FSRPAVAsQRRAWAT 7tm_1 X -PRKCA PKCA P17252 human MAP4 281295 P36225 MAP4 cow S815 4001700 PKSTTTSsVKKSTTV X -PRKCA PKCA P17252 human SNAP-25 6616 P60880 SNAP25 human T138 449875 GGFIRRVtNDARENE SNAP-25 X -PRKCA PKCA P17252 human INSR 3643 P06213 INSR human S1064 451563 kTVNEsAsLRERIEF PK_Tyr_Ser-Thr X -PRKCA PKCA P17252 human RAF1 5894 P04049 RAF1 human S43 447744 FGyQRRAsDDGKLtD X -PRKCA PKCA P17252 human FMNL2 iso3 114793 Q96PY5-3 FMNL2 human S1072 48891101 RADAVRRsVRRRFDD X X -PRKCA PKCA P17252 human RORA 6095 P35398 RORA human S35 12613703 ETPLNQEsArKSEPP X X -PRKCA PKCA P17252 human SLC18A2 6571 Q05940 SLC18A2 human S18 30332701 WLQEsRRsRKLILFI X -PRKCA PKCA P17252 human MMP2 4313 P08253 MMP2 human S365 479863 NKyEsCtsAGRsDGK Peptidase_M10; fn2 X -PRKCA PKCA P17252 human CACNA1C 100101555 P15381 CACB rabbit S1842 9808100 QEAAWKLssKRCHSQ CAC1F_C X -PRKCA PKCA P17252 human SH2-B-beta 25970 Q9NRF2 SH2B1 human S161 21336502 sLRsVGRsVRGsVRG X -PRKCA PKCA P17252 human RIGI 23586 O95786 RIGI human S8 12613701 MTTEQRRsLQAFQDY CARD_2 X X -PRKCA PKCA P17252 human Ebp1 5036 Q9UQ80 PA2G4 human T366 3850595 QssAsRKtQKKKKKk X -PRKCA PKCA P17252 human HMGA1 117062 Q8K585 Hmga1 rat S44 479856 PGTALVGsQKEPSEV X -PRKCA PKCA P17252 human Ret 5979 P07949 RET human T675 22553316 PISSAEMtFRRPAQA X -PRKCA PKCA P17252 human CYSLTR1 10800 Q9Y271 CYSLTR1 human S316 11146368 FRKHsLssVTYVPRK X -PRKCA PKCA P17252 human ADCY2 81636 P26769 Adcy2 rat S543 25795202 NRTLRTKsQKKRFEE Adcy_cons_dom X -PRKCA PKCA P17252 human CFLAR iso2 8837 O15519-2 CFLAR human S193 7590803 LQAAIQKsLKDPSNN X -PRKCA PKCA P17252 human GJA1 24392 P08050 Gja1 rat S368 447813 QRPssRAssRAssRP X 3511; 52559 -PRKCA PKCA P17252 human GRK2 156 P25098 GRK2 human S29 447724 ATPAARAskkILLPE X -PRKCA PKCA P17252 human Vimentin 7431 P08670 VIM human S10 455451 trsVssssyrrMFGG Filament_head X -PRKCA PKCA P17252 human PITPNC1 26207 Q9UKF7 PITPNC1 human S299 478664 KDRPRKKsAPEtLtL X -PRKCA PKCA P17252 human C5aR 728 P21730 C5AR1 human S334 448819 sVVREsKsFTRsTVD X -PRKCA PKCA P17252 human Vimentin 7431 P08670 VIM human S5 471086 ___MStrsVssssyr X -PRKCA PKCA P17252 human eIF4G 1981 Q04637 EIF4G1 human S1185 482920 RtPATKRsFskEVEE X X -PRKCA PKCA P17252 human TRPC3 7222 Q13507 TRPC3 human S785 454431 PPFsLVPsPKsFVyF X -PRKCA PKCA P17252 human SPHK1 20698 Q8CI15 Sphk1 mouse S373 51621300 DAPSGRDsRRGPPPE X X -PRKCA PKCA P17252 human NHERF 9368 O14745 NHERF1 human S77 957200 ETHQQVVsRIRAALN PDZ X -PRKCA PKCA P17252 human Kv3.4 3749 Q03721 KCNC4 human S15 451077 ssYRGRKsGNKPPsK Potassium_chann X -PRKCA PKCA P17252 human Claudin-1 9076 O95832 CLDN1 human T191 1869121000 CSCPRkTtsYPtPRP X -PRKCA PKCA P17252 human CTPS 1503 P17812 CTPS1 human S462 479852 tLFQTkNsVMRkLYG GATase X X -PRKCA PKCA P17252 human CK1D 64462 Q06486 Csnk1d rat T397 3362909 QDtsRMstsQIPGRV X -PRKCA PKCA P17252 human TNNI3 511094 P08057 TNNI3 cow T145 451483 RGKFKRPtLRRVRIS Troponin X -PRKCA PKCA P17252 human TGFBR1 7046 P36897 TGFBR1 human T200 4325704 LPLLVQRtIARtIVL TGF_beta_GS X X -PRKCA PKCA P17252 human IQGAP1 8826 P46940 IQGAP1 human S1443 454416 DKMKKsksVkEDsNL X X -PRKCA PKCA P17252 human EAR-2 2063 P10588 NR2F6 human S83 25802106 CKSFFKRsIRRNLsY zf-C4 X -PRKCA PKCA P17252 human KLHL3 26249 Q9UH77 KLHL3 human S433 36440206 PMNTRRSsVGVGVVE Kelch_1 X X -PRKCA PKCA P17252 human NFL 100521224 P02547 NEFL pig S28 457197 TPRVHISsVRSGYsT Filament_head X -PRKCA PKCA P17252 human TXA2-R iso2 6915 P21731-2 TBXA2R human T399 451396 LLPFEPPtGKALSRK X -PRKCA PKCA P17252 human PPP1R1A 5502 Q13522 PPP1R1A human S67 447758 LKSTLAMsPRQRKKM DARPP-32 X -PRKCA PKCA P17252 human CK1D 1453 P48730 CSNK1D human T161 1871153000 KKYRDARtHQHIPYR Pkinase X -PRKCA PKCA P17252 human CACNA1C 100101555 P15381 CACB rabbit S528 486358 ARLAHRIsKSKFsRY X -PRKCA PKCA P17252 human MOR-1 18390 P42866 Oprm1 mouse T370 447785 sARIRQNtREHPstA X -PRKCA PKCA P17252 human HuR 1994 Q15717 ELAVL1 human S158 478356 FIRFDKRsEAEEAIT RRM_1 X -PRKCA PKCA P17252 human PRKD1 5587 Q15139 PRKD1 human S738 448589 ARIIGEksFRRsVVG Pkinase X X 2054 -PRKCA PKCA P17252 human GJA1 2697 P17302 GJA1 human S372 465460 sRAssRAssRPRPDD X -PRKCA PKCA P17252 human GRF-1 2909 Q9NRY4 ARHGAP35 human T1226 7159800 LRsLRRNtKKPKPKP RhoGAP_pG1_pG2 X -PRKCA PKCA P17252 human HuR 1994 Q15717 ELAVL1 human S318 2246702 GDkILQVsFkTNkSH X -PRKCA PKCA P17252 human TNNT2 21956 P50752 Tnnt2 mouse T216 451556 RKsGKRQtEREKKKK Troponin X -PRKCA PKCA P17252 human PDE3A 5139 Q14432 PDE3A human S312 456900 SKSHRRTsLPCIPRE X X -PRKCA PKCA P17252 human KCNJ8 25472 Q63664 Kcnj8 rat S385 483976 NsLRKRNsMRRNNsM X -PRKCA PKCA P17252 human ANXA5 iso3 AAB24205 ANXA5 cow T22 2358301 DERADAEtLRKAMKG Annexin X -PRKCA PKCA P17252 human GluR6 54257 P42260 Grik2 rat S846 11496000 VGEFLYKsKKNAQLE X -PRKCA PKCA P17252 human Kit 3815 P10721 KIT human S741 450035 TkADkRRsVRIGsyI PK_Tyr_Ser-Thr X -PRKCA PKCA P17252 human CREM 12916 P27699 Crem mouse S133 448412 EILSRRPsYRKILNE pKID X 4095; 14228; 14001 -PRKCA PKCA P17252 human coronin 1B 57175 Q9BR76 CORO1B human S2 456131 ______MsFRKVVRQ X X -PRKCA PKCA P17252 human SNAP-25 20614 P60879 Snap25 mouse S187 448668 RIMEkADsNkTRIDE X -PRKCA PKCA P17252 human AA-NAT 25120 Q64666 Aanat rat T29 452141 LGCQRRHtLPASEFR X -PRKCA PKCA P17252 human CFTR 1080 P13569 CFTR human S660 449979 FSAERRNsILTETLH CFTR_R X -PRKCA PKCA P17252 human PPAR-alpha 25747 P37230 Ppara rat S142 457550 AYDKCDRsCKIQKKN zf-C4 X -PRKCA PKCA P17252 human CK1D 64462 Q06486 Csnk1d rat T329 31869461 ATRGLPstAsGRLRG X -PRKCA PKCA P17252 human GluR1 14799 P23818 Gria1 mouse T858 3362100 NEAIRtstLPRNsGA X X -PRKCA PKCA P17252 human GJA1 24392 P08050 Gja1 rat S369 459208 RPssRAssRAssRPR X -PRKCA PKCA P17252 human SLC22A1 24904 Q63089 Slc22a1 rat S286 455610 YYWFVPEsPRWLLsQ Sugar_tr X -PRKCA PKCA P17252 human KCNJ13 3769 O60928 KCNJ13 human S201 6039502 TRPSPLTsVRVSAVL IRK_C X -PRKCA PKCA P17252 human Claudin-7 1366 O95471 CLDN7 human S204 27732000 VPRsYPksNsskEyV X -PRKCA PKCA P17252 human PLCD1 P10688 Plcd1 rat S35 9993602 LLKVKSSsWRRERFY PH_12 X -PRKCA PKCA P17252 human PDE3A 5139 Q14432 PDE3A human S438 456984 PGLLRRVsstWtttt X X -PRKCA PKCA P17252 human SLC1A1 25550 P51907 Slc1a1 rat S465 471076 TGIVEKLsKKELEQV X -PRKCA PKCA P17252 human CDK1 396252 P13863 CDK1 chicken S277 465625 YDPAKRIsGKMALNH Pkinase X -PRKCA PKCA P17252 human GUCY2C 397193 P55204 GUCY2C pig S1052 451300 RKPTRVAsYKKGTLE X -PRKCA PKCA P17252 human KRas iso2 3845 P01116-2 KRAS human S181 459210 GKKKKkKskTkCVIM X -PRKCA PKCA P17252 human TH 25085 P04177 Th rat S40 448545 RFIGRRQsLIEDARK TOH_N X 2791 -PRKCA PKCA P17252 human APLP1 11803 Q03157 Aplp1 mouse T615 11500601 RKKKPYGtISHGVVE APP_amyloid X -PRKCA PKCA P17252 human PDE3A 5139 Q14432 PDE3A human S492 4787245 MTLTkSRsFtSSyAI X X -PRKCA PKCA P17252 human CACNA1C 24239 P22002 Cacna1c rat S1927 455278 ASLGRRAsFHLECLK CAC1F_C X X -PRKCA PKCA P17252 human SHOC2 8036 Q9UQ13 SHOC2 human S297 31905007 GLRYNRLsAIPRSLA LRR_8 X -PRKCA PKCA P17252 human Kv7.2 170848 O88943 Kcnq2 rat S541 11082901 sKRKFKEsLRPYDVM KCNQ_channel X -PRKCA PKCA P17252 human p47phox 653361 P14598 NCF1 human S315 451725 AHsIHQRsRKRLsQD NECFESHC X -PRKCA PKCA P17252 human CFTR 1080 P13569 CFTR human S686 449980 WTEtKKQsFKQTGEF CFTR_R X -PRKCA PKCA P17252 human CYP3A4 1576 P08684 CYP3A4 human S398 22553308 GVVVMIPsYALHRDP p450 X -PRKCA PKCA P17252 human SHP-1 5777 P29350 PTPN6 human S591 454019 DKEKsKGsLKRK___ X X -PRKCA PKCA P17252 human ADD2 119 P35612 ADD2 human S713 449802 KKKFRtPsFLKKsKK X -PRKCA PKCA P17252 human G-alpha(z) 2781 P19086 GNAZ human S27 451241 DRHLRSEsQRQRREI G-alpha X X -PRKCA PKCA P17252 human JAK2 3717 O60674 JAK2 human T174 56527200 kVPVTHEtQEECLGM FERM_F2 X -PRKCA PKCA P17252 human Kv4.2 Q63881 Kcnd2 rat S447 4668101 SANAYMQsKRNGLLS X -PRKCA PKCA P17252 human Cortactin 60465 A6HYF4 Cttn rat S172 15176497 QADRVDKsAVGFDYQ HS1_rep X -PRKCA PKCA P17252 human SERT 6532 P31645 SLC6A4 human S277 31014802 IWKGVKtsGKVVWVT SNF X -PRKCA PKCA P17252 human NR1I3 9970 Q14994 NR1I3 human T38 11281700 CKGFFRRtVSKSIGP zf-C4 X -PRKCA PKCA P17252 human AHR 196 P35869 AHR human S12 451412 SANITYAsRKRRKPV X -PRKCA PKCA P17252 human HIR 3761 P48050 KCNJ4 human T53 450871 IFTTCVDtRWRYMLM IRK X -PRKCA PKCA P17252 human SPIC 121599 Q8N5J4 SPIC human Y191 15570419 KIRRKLTyQFSEAIL Ets X -PRKCA PKCA P17252 human DYNC1I2 116659 Q62871 Dync1i2 rat S90 4033130 PPPMSPssKSVstPs X -PRKCA PKCA P17252 human PITPNB 114561 P53812 Pitpnb rat S262 451299 ETMRKKGsVRGTSAA X -PRKCA PKCA P17252 human ADD1 118 P35611 ADD1 human S726 449829 KKKFRtPsFLKKsKK X -PRKCA PKCA P17252 human CFLAR 8837 O15519 CFLAR human S193 7590803 LQAAIQksLkDPSNN X -PRKCA PKCA P17252 human RGS7 6000 P49802 RGS7 human S434 455540 YKLMKSDsYPRFIRS RGS X -PRKCA PKCA P17252 human neurogranin 616955 P35722 NRGN cow S36 455913 AAAKIQAsFRGHMAR IQ X -PRKCA PKCA P17252 human Kv7.2 3785 O43526 KCNQ2 human T217 457689 RMDRRGGtWKLLGSV Ion_trans; TM X X -PRKCA PKCA P17252 human PDE3A 5139 Q14432 PDE3A human S465 456985 VRRDRsTsIkLQEAP X X -PRKCA PKCA P17252 human SLC22A1 24904 Q63089 Slc22a1 rat S328 455613 LCLEEDAsEKRSPsF Sugar_tr X -PRKCA PKCA P17252 human MBP 618684 P02687 MBP cow S54 451832 RGAPKRGsGKDGHHA Myelin_MBP X -PRKCA PKCA P17252 human S6 29304 P62755 Rps6 rat S236 448093 AKRRRLssLRAstsK X 5006; 4856; 4857; 4858; 4851; 4803; 2211; 3945; 3985; 5316; 4854; 8520; 48319; 40643; 9865; 38573; 14733; 27036; 34411; 62016; 62788; 81736; 97935; 99457; 15448 -PRKCA PKCA P17252 human PPAR-gamma 5468 P37231 PPARG human T166 1880248400 CKGFFRRtIRLKLIY X X -PRKCA PKCA P17252 human CYBA 13057 Q61462 Cyba mouse T147 7103047 ERPQVGGtIkQPPTN Cytochrom_B558a X -PRKCA PKCA P17252 human NHERF E2RGF3 SLC9A3R1 dog S348 455752 ERAHQKRssKRAPQM EBP50_C X X -PRKCA PKCA P17252 human NOX5 iso4 79400 Q96PH1-4 NOX5 human S490 20612401 GRGSKRLsRSVtMRK FAD_binding_8 X X -PRKCA PKCA P17252 human NFL 100521224 P02547 NEFL pig S13 457195 SEPYYSTsYKRRYVE Filament_head X -PRKCA PKCA P17252 human CYP3A4 1576 P08684 CYP3A4 human S119 22553300 GFMksAIsIAEDEEW p450 X -PRKCA PKCA P17252 human GPSM2 29899 P81274 GPSM2 human S408 4766076 PKLGRRHsMENMELM X -PRKCA PKCA P17252 human Pim1 iso2 5292 P11309-2 PIM1 human S65 1190526800 HSHSPRHsLRHSPGS X X -PRKCA PKCA P17252 human p47phox 653361 P14598 NCF1 human S328 449404 QDAYRRNsVRFLQQR NECFESHC X -PRKCA PKCA P17252 human RASSF1 iso2 11186 Q9NS23-2 RASSF1 human S197 18748000 RGPGRGTsVRRRtsF X X -PRKCA PKCA P17252 human p40phox 4689 Q15080 NCF4 human T154 448266 LRRLRPRtRKVKSVs X X 4311 -PRKCA PKCA P17252 human CACNA1B 257648 Q02294 Cacna1b rat S898 455281 ARPRRsHsKEAPGAD X -PRKCA PKCA P17252 human CYP3A4 1576 P08684 CYP3A4 human S420 5938007 kFLPERFsKKNKDNI p450 X -PRKCA PKCA P17252 human NKX3-1 4824 Q99801 NKX3-1 human S48 3078000 RQGGRTSsQRQRDPE X X -PRKCA PKCA P17252 human NMDAR2C 24411 Q00961 Grin2c rat S1231 463822 SCTWRRVssLEsEV_ X X -PRKCA PKCA P17252 human p53 7157 P04637 TP53 human S378 447534 skkGQstsRHkkLMF X -PRKCA PKCA P17252 human occludin 18260 Q61146 Ocln mouse S338 455819 GKRSYPEsFYKSTPL X -PRKCA PKCA P17252 human ROBO3 64221 Q96MS0 ROBO3 human S1330 15414501 WLPYSRPsFLSrGQG X X -PRKCA PKCA P17252 human CD5 921 P06127 CD5 human T434 450129 MsFHRNHtAtVRsHA X -PRKCA PKCA P17252 human DAT 6531 Q01959 SLC6A3 human S7 451136 _MsKskCsVGLMssV X -PRKCA PKCA P17252 human p73 7161 O15350 TP73 human S388 6417400 VPQPLVDsYRQQQQL X -PRKCA PKCA P17252 human GNMT 27232 Q14749 GNMT human S10 460706 DSVYRtRsLGVAAEG X -PRKCA PKCA P17252 human CHAT iso3 1103 P28329-3 CHAT human S476 454037 HKAAVPAsEKLLLLK Carn_acyltransf X -PRKCA PKCA P17252 human PCYT2 68671 Q922E4 Pcyt2 mouse S215 31834925 VsQFLQTsQKIIQFA X -PRKCA PKCA P17252 human AFAP 60312 Q8N556 AFAP1 human S277 2853100 AELEKKLssERPssD X -PRKCA PKCA P17252 human MBP 618684 P02687 MBP cow S160 456582 FKLGGRDsRSGsPMA Myelin_MBP X -PRKCA PKCA P17252 human PPP1R16B 26051 Q96T49 PPP1R16B human S331 62459400 sQLRHKSsLsRRTsS X X -PRKCA PKCA P17252 human PTPRA 19262 P18052 Ptpra mouse S180 447611 QAGsHSNsFRLSNGR X -PRKCA PKCA P17252 human VDR 7421 P11473 VDR human S51 451285 CKGFFRRsMKRKALF zf-C4 X -PRKCA PKCA P17252 human PEA-15 100736554 Q9Z297 Pea15 hamster S104 455750 TKLTRIPsAKKYKDI X -PRKCA PKCA P17252 human MMP2 4313 P08253 MMP2 human T250 479859 EYNsCTDtGRSDGFL Peptidase_M10; fn2 X -PRKCA PKCA P17252 human F3 2152 P13726 F3 human S290 451613 GQsWkENsPLNVs__ X -PRKCA PKCA P17252 human hnRNP A1 29578 P04256 Hnrnpa1 rat S231 2874411 GrGGFGGsrGGGGYG X -PRKCA PKCA P17252 human MRLC1 10398 P24844 MYL9 human S2 4964101 ______MssKRAKAK X -PRKCA PKCA P17252 human GJA1 2697 P17302 GJA1 human S368 447813 QRPssRAssRAssRP X X 3511; 52559 -PRKCA PKCA P17252 human CYP2E1 1571 P05181 CYP2E1 human T373 23940002 SNLPHEAtRDtIFrG p450 X -PRKCA PKCA P17252 human ephexin-5 442801 Q5FWH6 Arhgef15 mouse S109 17546059 PVSRRsIsPEPAPCS X X -PRKCA PKCA P17252 human ADRA1D 146 P25100 ADRA1D human S516 1346843003 QLRAKVssLsHKIRA X -PRKCA PKCA P17252 human KCNK9 51305 Q9NPC2 KCNK9 human T341 40686300 IEEISPStLKNSLFP X -PRKCA PKCA P17252 human CELF1 10658 Q92879 CELF1 human S178 29668006 AQtMEGCssPMVVkF RRM_1 X -PRKCA PKCA P17252 human TNNT2 286816 P13789 TNNT2 cow T281 451557 TRGKAKVtGRWK___ X -PRKCA PKCA P17252 human NG2 81651 Q00657 Cspg4 rat T2256 454952 YLRKRNKtGKHDVQV X X -PRKCA PKCA P17252 human CYP3A4 1576 P08684 CYP3A4 human S134 17547617 kRLRsLLsPtFTsGK p450 X -PRKCA PKCA P17252 human TNNI3 29248 P23693 Tnni3 rat S24 448424 APVRRRssANYRAYA Troponin-I_N X 4004 -PRKCA PKCA P17252 human STXBP1 25558 P61765 Stxbp1 rat S313 448744 sLkDFSSsKRMNTGE Sec1 X -PRKCA PKCA P17252 human CYP2E1 1571 P05181 CYP2E1 human T131 23940009 DIRRFsLttLRNYGM p450 X -PRKCA PKCA P17252 human PDLIM2 213019 Q8R1G6 Pdlim2 mouse S137 4763817 PRPCsPFstPPPtsP X X -PRKCA PKCA P17252 human DLG1 1739 Q12959 DLG1 human T657 22496705 KERARLKtVkFNsKT X -PRKCA PKCA P17252 human lamin A/C 16905 P48678 Lmna mouse S575 1207201 RGsHCsGsGDPAEYN X -PRKCA PKCA P17252 human CHAT iso3 1103 P28329-3 CHAT human S346 454035 LLKHVTQssRKLIRA Carn_acyltransf X -PRKCA PKCA P17252 human CFTR 1080 P13569 CFTR human S795 449982 TAsTRKVsLAPQANL CFTR_R X -PRKCA PKCA P17252 human KCNMA1 282573 Q28204 KCNMA1 cow S1151 14364501 NRQNRPKsRESRDKQ X -PRKCA PKCA P17252 human H3 8350 P68431 H3C1 human T6 13321500 __ArtkQtArkstGG Histone X -PRKCA PKCA P17252 human CK1D 1453 P48730 CSNK1D human S191 1871153002 THLGIEQsRRDDLES Pkinase X -PRKCA PKCA P17252 human SCN9A iso3 6335 Q15858-3 SCN9A human I848 1871432202 LNMLIKIiGNSVGAL Ion_trans X -PRKCA PKCA P17252 human EGLN2 112398 Q96KS0 EGLN2 human S234 4213802 QRAIPPRsIRGDQIA X -PRKCA PKCA P17252 human AID 11628 Q9WVE0 Aicda mouse T140 6835300 GVQIGIMtFKDYFYC APOBEC2 X -PRKCA PKCA P17252 human CD44 960 P16070 CD44 human S672 455524 AVCIAVNsRRRCGQK X -PRKCA PKCA P17252 human CYP3A4 1576 P08684 CYP3A4 human T103 22553306 KECYsVFtNRRPFGP p450 X -PRKCA PKCA P17252 human HABP4 22927 Q5JVS0 HABP4 human T375 11380903 GRGARGGtRGGRGRI IHABP4_N X -PRKCA PKCA P17252 human KCNJ8 25472 Q63664 Kcnj8 rat S397 471151 NsMRRSNsIRRNNSS X -PRKCA PKCA P17252 human GluR1 50592 P19490 Gria1 rat S836 467226 CYkSRSEskRMkGFC X X -PRKCA PKCA P17252 human PRKD2 25865 Q9BZL6 PRKD2 human S876 448800 QGLAERIsVL_____ X -PRKCA PKCA P17252 human TXN 7295 P10599 TXN human T100 457590 NkEkLEAtINELV__ Thioredoxin X -PRKCA PKCA P17252 human ASIC3 286920 O35240 Asic3 rat S523 12518703 VTKTLSAsHRTCYLV X -PRKCA PKCA P17252 human GSTA4 2941 O15217 GSTA4 human T193 455667 VKLsNIPtIKRFLEP GST_C_3 X -PRKCA PKCA P17252 human TNNT2 7139 P45379 TNNT2 human S189 4708251 ARKKKALsNMMHFGG Troponin X -PRKCA PKCA P17252 human PPP1R14B 26472 Q96C90 PPP1R14B human T57 1904503 VRRQGKVtVkYDRKE PP1_inhibitor X -PRKCA PKCA P17252 human PLCB1 P10894 PLCB1 cow S887 450172 HSQPAPGsVKAPAKT X -PRKCA PKCA P17252 human kindlin-3 83706 Q86UX7 FERMT3 human S484 15424197 LSLQRtGsGGPGNHP FERM_M X -PRKCA PKCA P17252 human TRPV5 56302 Q9NQA5 TRPV5 human S654 470109 yVEVFKNsDKEDDQE X -PRKCA PKCA P17252 human VTN 7448 P04004 VTN human S381 452175 RNRKGYRsQRGHsRG X -PRKCA PKCA P17252 human PLM 476487 P56513 FXYD1 dog T89 455220 SsIRRLstRRR____ X -PRKCA PKCA P17252 human p300 2033 Q09472 EP300 human S89 447592 SELLRSGsSPNLNMG X -PRKCA PKCA P17252 human IKKB 3551 O14920 IKBKB human S177 447492 AkELDQGsLCtsFVG Pkinase X 2078; 2697; 2694; 14938; 92255; 36516; 36214 -PRKCA PKCA P17252 human ICOSLG 23308 O75144 ICOSLG human S285 33625706 RDRCLQHsYAGAWAV X -PRKCA PKCA P17252 human TUBA1C 84790 Q9BQE3 TUBA1C human S158 4710870 sLLMERLsVDyGkks Tubulin X -PRKCA PKCA P17252 human C5aR 728 P21730 C5AR1 human S317 450056 RLRKsLPsLLRNVLt X -PRKCA PKCA P17252 human IL2RA 3559 P01589 IL2RA human T271 455370 RQRKsRRtI______ X X -PRKCA PKCA P17252 human CYP2E1 1571 P05181 CYP2E1 human T432 23940011 DYFkPFstGkRVCAG p450 X -PRKCA PKCA P17252 human SCN2A 24766 P04775 Scn2a rat S1506 2999207 NAMKKLGsKKPQKPI X -PRKCA PKCA P17252 human CK1D 1453 P48730 CSNK1D human T176 1868926302 ENkNLtGtARYAsIN Pkinase X X -PRKCA PKCA P17252 human TNNT2 21956 P50752 Tnnt2 mouse S211 451755 QAQtERKsGKRQtER Troponin X -PRKCA PKCA P17252 human pleckstrin 5341 P08567 PLEK human S113 451305 GQKFARKstRRsIRL X X -PRKCA PKCA P17252 human ADRA1D 146 P25100 ADRA1D human S518 1346843000 RAKVssLsHKIRAGG X -PRKCA PKCA P17252 human ICLN 403971 P35521 CLNS1A dog S45 456841 YIAESRLsWLDGSGL Voldacs X -PRKCA PKCA P17252 human DOCK8 81704 Q8NF50 DOCK8 human S2077 3929061 KPIFRVEsQKRDsFH X -PRKCA PKCA P17252 human HDAC5 10014 Q9UQL6 HDAC5 human S259 447995 FPLRkTAsEPNLKVR X 3443 -PRKCA PKCA P17252 human GPR120 iso1 338557 Q5NUL3-1 FFAR4 human T363 31014807 PEKGAILtDtsVKRN X -PRKCA PKCA P17252 human SHOC2 8036 Q9UQ13 SHOC2 human T71 34669125 VAFSVDNtIKRPNPA X -PRKCA PKCA P17252 human calcyon 192349 P58821 Caly rat S169 25687501 MPAIWGNsYRAGKEE Calcyon X -PRKCA PKCA P17252 human MBP 618684 P02687 MBP cow S7 451831 _AAQKRPsQRsKYLA X -PRKCA PKCA P17252 human TRPM4 54795 Q8TD43 TRPM4 human S1145 12559511 RDKRESDsERLKRTs X -PRKCA PKCA P17252 human Vimentin 7431 P08670 VIM human S7 455449 _MStrsVssssyrrM Filament_head X -PRKCA PKCA P17252 human Ku70 2547 P12956 XRCC6 human S78 1875071708 YISKIIssDRDLLAV Ku_N X X -PRKCA PKCA P17252 human IREB1 48 P21399 ACO1 human S138 451387 DFNRRADsLQkNQDL Aconitase X -PRKCA PKCA P17252 human H2B 3018 P33778 H2BC3 human S32 447801 DGKkRKRsRkEsysI Histone X -PRKCA PKCA P17252 human MYBPC1 iso2 109272 G0YZM8 Mybpc1 mouse S83 21560212 QNANSQLstLFVEKP X -PRKCA PKCA P17252 human PPP1CA 100009298 P62139 PPP1CA rabbit S325 452050 PItPPRNsAKAKK__ X -PRKCA PKCA P17252 human CYP2E1 1571 P05181 CYP2E1 human S145 23940000 MGKQGNEsRIQREAH p450 X -PRKCA PKCA P17252 human AHR 196 P35869 AHR human S36 451413 EGIkSNPsKRHRDRL HLH X -PRKCA PKCA P17252 human hnRNP A1 29578 P04256 Hnrnpa1 rat S192 456539 EMASASSsQRGRsGs X -PRKCA PKCA P17252 human IRS1 25467 P35570 Irs1 rat S307 447558 TEsITATsPASMVGG X 2381 -PRKCA PKCA P17252 human GPSM2 76123 Q8VDU0 Gpsm2 mouse S408 4766076 AKLGRRHsMENLELM X -PRKCA PKCA P17252 human PKCE 5581 Q02156 PRKCE human S368 2085101 NNIRKALsFDNRGEE X -PRKCA PKCA P17252 human MARCKS 4082 P29966 MARCKS human S170 451837 sFkLsGFsFkKNKkE MARCKS X -PRKCA PKCA P17252 human CD3G 917 P09693 CD3G human S148 451430 GVRQsRAsDkQTLLP X -PRKCA PKCA P17252 human GJA1 24392 P08050 Gja1 rat S373 459209 RAssRAssRPRPDDL X -PRKCA PKCA P17252 human p47phox 653361 P14598 NCF1 human S303 449405 RGAPPRRssIRNAHs NECFESHC X -PRKCA PKCA P17252 human GPR120 iso1 338557 Q5NUL3-1 FFAR4 human S373 31014806 sVKRNDLsIIsG___ X -PRKCA PKCA P17252 human IREM-1 146722 Q8TDQ1 CD300LF human T221 1868016201 GTsPQKAtTKLSSAQ SIT X -PRKCA PKCA P17252 human IKKB 3551 O14920 IKBKB human S181 447489 DQGsLCtsFVGTLQy Pkinase X 2697; 2694; 14938; 92255; 36516; 36214 -PRKCA PKCA P17252 human ILK 3611 Q13418 ILK human T181 6191018 RTRPRNGtLNkHsGI X -PRKCA PKCA P17252 human NR2C1 22025 Q505F1 Nr2c1 mouse S461 456551 MSPERRKsLMEHIFK Hormone_recep X -PRKCA PKCA P17252 human FMIP 8563 Q13769 THOC5 human S5 453432 ___MSSEssKKRKPK X X -PRKCA PKCA P17252 human F3 2152 P13726 F3 human S285 451611 RKAGVGQsWkENsPL X -PRKCA PKCA P17252 human TAGLN2 8407 P37802 TAGLN2 human T180 4786351 VIGLQMGtNrGAsQA Calponin X -PRKCA PKCA P17252 human PTGIR 5739 P43119 PTGIR human S328 450985 TPLSQLAsGRRDPRA X -PRKCA PKCA P17252 human TAGLN2 8407 P37802 TAGLN2 human S11 27462345 rGPAyGLsREVQQkI X -PRKCA PKCA P17252 human NOXO1 iso3 124056 Q8NFA2-3 NOXO1 human S154 27454492 SRAAGRLsIHSLEAQ X X -PRKCA PKCA P17252 human ANXA2 12306 P07356 Anxa2 mouse S26 450879 tPPsAyGsVKPytNF X -PRKCA PKCA P17252 human MOR-1 25601 P33535 Oprm1 rat S363 447783 stIEQQNsTRVRQNt X -PRKCA PKCA P17252 human ILK 3611 Q13418 ILK human T173 479406 DTFWkGttRTRPRNG X X -PRKCA PKCA P17252 human CYP3A4 1576 P08684 CYP3A4 human S259 22553301 SVKRMKEsRLEDtQK p450 X -PRKCA PKCA P17252 human GSTP1 2950 P09211 GSTP1 human S185 455118 SAYVGRLsARPkLkA GST_C_3 X X -PRKCA PKCA P17252 human PRKD1 5587 Q15139 PRKD1 human S742 448590 GEksFRRsVVGtPAy Pkinase X X -PRKCA PKCA P17252 human HABP4 22927 Q5JVS0 HABP4 human T354 11380902 RKPANDItSQLEINF IHABP4_N X -PRKCA PKCA P17252 human CACNA1C 100101555 P15381 CACB rabbit S1674 480102 QGLVGKPsQRNALSL X -PRKCA PKCA P17252 human PLCB3 5331 Q01970 PLCB3 human S1105 448448 LDRKRHNsIsEAKMR PLC-beta_C X X 2484 -PRKCA PKCA P17252 human EPB41 iso4 2035 P11171-4 EPB41 human S331 451158 RTASKRAsRSLDGAA FA X -PRKCA PKCA P17252 human CD5 921 P06127 CD5 human T436 450130 FHRNHtAtVRsHAEN X -PRKCA PKCA P17252 human RhoGDI alpha 192662 Q99PT1 Arhgdia mouse S96 486318 DLTGDLEsFkkQsFV Rho_GDI X -PRKCA PKCA P17252 human TAGLN 6876 Q01995 TAGLN human S181 469978 VIGLQMGsNrGAsQA Calponin X -PRKCA PKCA P17252 human PLD2 5338 O14939 PLD2 human S243 456497 RWLVVKDsFLLYMCL X -PRKCA PKCA P17252 human MARCKS 613548 P12624 MARCKS cow S158 447786 KKKKKRFsFKKsFKL MARCKS X 11992 -PRKCA PKCA P17252 human CYBA 1535 P13498 CYBA human T147 7103047 ERPQIGGtIkQPPsN Cytochrom_B558a X -PRKCA PKCA P17252 human SUN1 23353 O94901 SUN1 human S55 179463700 sPRMsRRsLRLATTA X -PRKCA PKCA P17252 human IRS1 25467 P35570 Irs1 rat S24 455604 GYLRKPKsMHKRFFV PH X -PRKCA PKCA P17252 human MBP 618684 P02687 MBP cow S45 10306407 SLGRFFGsDRGAPKR Myelin_MBP X -PRKCA PKCA P17252 human SLC29A1 63959 Q9JIM1 Slc29a1 mouse T276 21326705 PGPNsPPtNRNQsIK Nucleoside_tran X -PRKCA PKCA P17252 human ADD1 118 P35611 ADD1 human S716 449828 GsPGKsPsKKKKKFR X -PRKCA PKCA P17252 human PLCB1 24654 P10687 Plcb1 rat S887 450172 HSQPAPGsVKAPAKT X X -PRKCA PKCA P17252 human CFTR 1080 P13569 CFTR human S641 2907508 QNLQPDFsSKLMGCD CFTR_R X -PRKCA PKCA P17252 human RASSF1 iso2 11186 Q9NS23-2 RASSF1 human S203 484000 TsVRRRtsFYLPKDA RA X X -PRKCA PKCA P17252 human rabphilin 3A 171039 P47709 Rph3a rat S274 455801 QGLRRANsVQASRPA X -PRKCA PKCA P17252 human p47phox 653361 P14598 NCF1 human S359 451729 EERQtQRsKPQPAVP p47_phox_C X -PRKCA PKCA P17252 human VASP 7408 P50552 VASP human S157 448379 EHIERRVsNAGGPPA X 3111; 84519 -PRKCA PKCA P17252 human CYP2E1 1571 P05181 CYP2E1 human T376 23940013 PHEAtRDtIFrGYLI p450 X -PRKCA PKCA P17252 human myogenin 17928 P12979 Myog mouse T87 451161 VDRRRAAtLREKRRL HLH X -PRKCA PKCA P17252 human Titin 7273 Q8WZ42 TTN human S11878 10029600 KEEVVLKsVLRKRPE X -PRKCA PKCA P17252 human Caldesmon 100009077 Q28708 CALD1 rabbit S529 448466 QSVDKVTsPTKV___ X -PRKCA PKCA P17252 human BKR2 624 P30411 BDKRB2 human S373 447664 sMGTLRTsIsVERQI X -PRKCA PKCA P17252 human HOXA9 15405 P09631 Hoxa9 mouse S204 2906100 ANWLHARstRKKRCP X -PRKCA PKCA P17252 human TRPV5 Q9XSM3 Trpv5 rabbit S299 470108 FLELVVSsKKREARQ X -PRKCA PKCA P17252 human NPHS1 4868 O60500 NPHS1 human T1120 18507016 EYEESQWtGERDtQS X X -PRKCA PKCA P17252 human NFL 100521224 P02547 NEFL pig S34 457198 SsVRSGYsTARSAYS Filament_head X -PRKCA PKCA P17252 human SCN5A 6331 Q14524 SCN5A human S1503 9993604 NAMKKLGsKKPQKPI X -PRKCA PKCA P17252 human CFTR 1080 P13569 CFTR human S813 449983 DIYsRRLsQEtGLEI CFTR_R X -PRKCA PKCA P17252 human HMGA1 117062 Q8K585 Hmga1 rat S64 3136103 PRGRPKGsKNKGTAK X -PRKCA PKCA P17252 human NMNAT1 64802 Q9HAN9 NMNAT1 human S136 478388 WTETQDSsQKKSLEP CTP_transf_like X -PRKCA PKCA P17252 human CACNA1C 100101555 P15381 CACB rabbit S1517 460572 DYLTRDWsILGPHHL Ion_trans X -PRKCA PKCA P17252 human TNNT2 21956 P50752 Tnnt2 mouse T297 451557 TRGKAKVtGRWK___ Troponin X -PRKCA PKCA P17252 human FMIP 8563 Q13769 THOC5 human S6 453433 __MSSEssKKRKPKV X X -PRKCA PKCA P17252 human NFL 100521224 P02547 NEFL pig S52 457199 APVSSSLsVRRSYSS Filament_head X -PRKCA PKCA P17252 human CYP2E1 1571 P05181 CYP2E1 human T121 23940007 IIFNNGPtWKDIRRF p450 X -PRKCA PKCA P17252 human GluR1 2890 P42261 GRIA1 human S834 9486201 EFcYKsRsEsKRMKG X -PRKCA PKCA P17252 human DRD2 1813 P14416 DRD2 human S229 487433 RVNtkRssRAFRAHL 7tm_1 X -PRKCA PKCA P17252 human TNNI3 7137 P19429 TNNI3 human S24 448424 APIRRRssNyRAyAt Troponin-I_N X 4004 -PRKCA PKCA P17252 human RALBP1 10928 Q15311 RALBP1 human T297 3136101 ACGRTTEtEkVQEFQ RhoGAP X -PRKCA PKCA P17252 human DTNB 1838 O60941 DTNB human T69 27100602 FRDNGLNtLDHTTEI EF-hand_2 X -PRKCA PKCA P17252 human GluR6 54257 P42260 Grik2 rat S868 478417 MVEELRMsLKCQRRL X -PRKCA PKCA P17252 human IGFBP1 3484 P08833 IGFBP1 human S194 451660 LAKAQETsGEEIsKF Thyroglobulin_1 X -PRKCA PKCA P17252 human GPR15 2838 P49685 GPR15 human S357 125971702 FARRRKRsVsL____ X -PRKCA PKCA P17252 human DRD2 1813 P14416 DRD2 human S228 487432 kRVNtkRssRAFRAH 7tm_1 X -PRKCA PKCA P17252 human Met 4233 P08581 MET human S985 450188 PHLDRLVsARsVsPt X -PRKCA PKCA P17252 human GluR1 2890 P42261 GRIA1 human S849 448565 FCLIPQQsINEAIRT X X 75574 -PRKCA PKCA P17252 human TWIST1 7291 Q15672 TWIST1 human S144 41455181 tLPSDkLskIQTLkL HLH X -PRKCA PKCA P17252 human Tau iso8 4137 P10636-8 MAPT human S305 487457 kHVPGGGsVQIVykP Tubulin-binding X -PRKCA PKCA P17252 human GluR2 29627 P19491 Gria2 rat S880 448351 yNVyGIEsVkI____ X -PRKCA PKCA P17252 human Kv1.5 3741 P22460 KCNA5 human T15 465994 LENGGAMtVRGGDEA X -PRKCA PKCA P17252 human PPAR-alpha 25747 P37230 Ppara rat S179 457549 RFGRMPRsEKAKLKA X -PRKCA PKCA P17252 human Akt1 207 P31749 AKT1 human T308 447856 kDGAtMKtFCGtPEy Pkinase X 5106; 2965; 9275; 4056; 5056; 13842; 13038; 43506; 48646; 86758; 80722; 77440; 80556 -PRKCA PKCA P17252 human ITGB4 3691 P16144 ITGB4 human S1494 465821 tLtRDyNsLtRsEHs X X -MAP4K2 GCK Q12851 human LATS1 9113 O95835 LATS1 human T1079 457595 EHAFyEFtFRRFFDD X 8654 -MAP4K2 GCK Q12851 human PSMD2 5708 Q13200 PSMD2 human S361 487471 ENNrFGGsGsQVDsA X -MAP4K2 GCK Q12851 human PRH 5555 P02810 PRH2 human S24 451070 QDLDEDVsQEDVPLV Pro-rich X -MAP4K2 GCK Q12851 human Huntingtin 3064 P42858 HTT human T3 10206804 _____MAtLEkLMkA X X -plk1 PLK1 P70032 frog MASTL 84930 Q96GX5 MASTL human S875 3209091 tAQHLtVsGFsL___ X -plk1 PLK1 P70032 frog MASTL 84930 Q96GX5 MASTL human T860 58984001 QPDDETDtSYFEARN X -plk1 PLK1 P70032 frog MASTL 84930 Q96GX5 MASTL human T75 58984000 DMINkNMtHQVQAER Pkinase X -plk1 PLK1 P70032 frog MASTL 84930 Q96GX5 MASTL human S597 58984002 SDRSIKEssFEESNI X -plk1 PLK1 P70032 frog MASTL 84930 Q96GX5 MASTL human S598 15412079 DRSIKEssFEESNIE X -plk1 PLK1 P70032 frog MASTL 84930 Q96GX5 MASTL human T873 57812701 RNtAQHLtVsGFsL_ X -plk1 PLK1 P70032 frog MASTL 84930 Q96GX5 MASTL human S512 3209079 NkENIVNsFtDkQQt X -plk1 PLK1 P70032 frog MASTL 84930 Q96GX5 MASTL human S552 3209082 KRDYLsssFLCsDDD X -STK26 MST4 Q9P289 human Ezrin 7430 P15311 EZR human T567 448104 QGRDkyKtLRQIRQG ERM_C X X 3141; 3726; 32600 -STK26 MST4 Q9P289 human YAP1 10413 P46937 YAP1 human S94 3253276 RLRkLPDsFFkPPEP X -STK26 MST4 Q9P289 human AMPKA1 5562 Q13131 PRKAA1 human T183 448786 sDGEFLRtsCGsPNy Pkinase X 2535; 2531; 4188; 5256; 50081; 74281 -STK26 MST4 Q9P289 human KEPI 81706 Q8TAE6 PPP1R14C human T73 10296602 RHQQGKVtVkYDRKE PP1_inhibitor X -STK26 MST4 Q9P289 human YAP1 10413 P46937 YAP1 human T83 27460703 ktANVPQtVPMRLRk X X -STK26 MST4 Q9P289 human DDEFL1 55616 Q8TDY4 ASAP3 human T545 181213000 HRFARRCtPEPQRLW X -STK26 MST4 Q9P289 human TRAF6 22034 P70196 Traf6 mouse T494 34362608 LEALRQGtFIKDDTL X -STK26 MST4 Q9P289 human YAP1 10413 P46937 YAP1 human T77 126835301 NAVMNPktANVPQtV X -STK26 MST4 Q9P289 human PDCD10 11235 Q9BUL8 PDCD10 human T43 7452901 VNLsAAQtLRAAFIk DUF1241 X -STK26 MST4 Q9P289 human TRAF6 22034 P70196 Traf6 mouse T471 40240800 LLAFQRPtIPRNPKG X -STK26 MST4 Q9P289 human YAP1 10413 P46937 YAP1 human T41 1868502600 GQPAPAAtQAAPQAP X -STK26 MST4 Q9P289 human QSK 23387 Q9Y2K2 SIK3 human T221 456036 TPGQLLKtWCGSPPY Pkinase X -STK26 MST4 Q9P289 human PDCD10 11235 Q9BUL8 PDCD10 human S39 7452900 ELERVNLsAAQtLRA DUF1241 X -STK26 MST4 Q9P289 human YAP1 10413 P46937 YAP1 human T110 452306 sHsRQAstDAGtAGA X -STK26 MST4 Q9P289 human ATG4B 23192 Q9Y4P1 ATG4B human S383 470896 RLERFFDsEDEDFEI ATG4_LIR X X 19386; 40592 -Aurkb AurB O70126 mouse Vimentin 22352 P20152 Vim mouse S73 449025 sAVRLRssVPGVRLL Filament_head X X -Aurkb AurB O70126 mouse HEC1 67052 Q9D0F1 Ndc80 mouse S55 459763 PTSERKVsIFGKRTs Ndc80_HEC X -Aurkb AurB O70126 mouse Vimentin 22352 P20152 Vim mouse S65 2301100 GGAyVtRssAVRLRs Filament_head X -Aurkb AurB O70126 mouse H3 360198 P68433 H3c1 mouse S10 455676 tkQTARkstGGkAPr Histone X 9701; 9711; 9606; 3465; 3642; 3377; 3475; 3458; 5764; 47398; 8481; 8552; 53348; 29237; 66065; 43185; 64522; 52725 -Aurkb AurB O70126 mouse CASP2 12366 P29594 Casp2 mouse S384 1869992407 MRNTKRGsWYIEALT Peptidase_C14 X -Aurkb AurB O70126 mouse Vimentin 22352 P20152 Vim mouse S87 2301101 LQDsVdFsLADAINT Filament_head X -Aurkb AurB O70126 mouse Vimentin 22352 P20152 Vim mouse S7 455449 _MSTRsVssssYRRM Filament_head X -Aurkb AurB O70126 mouse SGOL2 68549 Q7TSY8 Sgo2a mouse T521 27462598 LSKPSRQtFVIRKSE X -Aurkb AurB O70126 mouse SGOL2 68549 Q7TSY8 Sgo2a mouse T600 89115100 KQKINRRtKIISVMS X -Aurkb AurB O70126 mouse Vimentin 22352 P20152 Vim mouse S25 455453 sGTssRPssNRsYVT Filament_head X -Aurkb AurB O70126 mouse Vimentin 22352 P20152 Vim mouse S39 451766 TTsTRTysLGsALRP Filament_head X 13614 -Aurkb AurB O70126 mouse H3 iso3 15081 P84244 H3f3b mouse S10 455676 tKQTARksTGGkAPR Histone X X 9701; 9711; 9706; 3465; 3642; 3377; 3475; 3458; 5764; 47398; 8481; 8552; 53348; 29237; 66065; 43185; 64522; 52725 -Aurkb AurB O70126 mouse H3 360198 P68433 H3c1 mouse S28 455677 ATkAArksAPATGGV Histone X 9713 -Aurkb AurB O70126 mouse Vimentin 22352 P20152 Vim mouse S66 451765 GAyVtRssAVRLRss Filament_head X -Aurkb AurB O70126 mouse Vimentin 22352 P20152 Vim mouse S47 455455 LGsALRPstsRsLys Filament_head X -Aurkb AurB O70126 mouse K5 110308 Q922U2 Krt5 mouse S31 4769949 tPsVsRTsFssVsRS Keratin_2_head X X -Phkg2 PHKG2 Q9DB30 mouse QSK 23387 Q9Y2K2 SIK3 human S551 468543 GPLGRRAsDGGANIQ X -Phkg2 PHKG2 Q9DB30 mouse QSK 23387 Q9Y2K2 SIK3 human T469 480134 YLSMRRHtVGVADPR X -SRMS SRMS Q9H3Y6 human MKK4 6416 P45985 MAP2K4 human Y307 1881548608 LATGRFPyPKWNSVF X -SRMS SRMS Q9H3Y6 human Brk 5753 Q13882 PTK6 human Y447 450276 RLSSFtsyENPT___ X X -SRMS SRMS Q9H3Y6 human MKK4 6416 P45985 MAP2K4 human Y269 1881548606 RDAGCRPyMAPERID X -SRMS SRMS Q9H3Y6 human FKBP5 2289 Q13451 FKBP5 human Y54 456461 PMIGDKVyVHYKGKL FKBP_C X -SRMS SRMS Q9H3Y6 human SRMS 6725 Q9H3Y6 SRMS human Y380 1873559810 RLLKDDIySPSSSSK PK_Tyr_Ser-Thr X -Stk4 MST1 Q9JI11 mouse IkB-alpha 18035 Q9Z1E3 Nfkbia mouse S32 448203 LVDDRHDsGLDsMKD X 5210; 2859; 9246; 5209 -Stk4 MST1 Q9JI11 mouse IkB-alpha 18035 Q9Z1E3 Nfkbia mouse S36 448204 RHDsGLDsMKDEEYE X 5210; 9246 -Stk4 MST1 Q9JI11 mouse MST1 58231 Q9JI11 Stk4 mouse T387 450050 tMKRRDEtMQPAKPS X -Stk4 MST1 Q9JI11 mouse MST1 58231 Q9JI11 Stk4 mouse T177 450049 VAGQLTDtMAKRNtV Pkinase X -Stk4 MST1 Q9JI11 mouse MST1 58231 Q9JI11 Stk4 mouse T183 447925 DtMAKRNtVIGTPFW Pkinase X 3681; 49332 -Gsk3a GSK3A Q2NL51 mouse YAF2 67057 Q99LW6 Yaf2 mouse S166 3205731 RGVsRsssPRGEAss X -Gsk3a GSK3A Q2NL51 mouse PXN 19303 Q8VI36 Pxn mouse S126 450227 sFPNKQksAEPsPtV Paxillin X -Gsk3a GSK3A Q2NL51 mouse Cbl-b 208650 Q3TTA7 Cblb mouse S476 3823372 KCTDRQNsPVtsPGs X -Gsk3a GSK3A Q2NL51 mouse neurogenin 2 11924 P70447 Neurog2 mouse S231 2255101 SPYSCTLsPAsPGSD X -Gsk3a GSK3A Q2NL51 mouse Cbl-b 208650 Q3TTA7 Cblb mouse S480 4717392 RQNsPVtsPGssPLA X -Gsk3a GSK3A Q2NL51 mouse neurogenin 2 11924 P70447 Neurog2 mouse S234 2255100 SCTLsPAsPGSDVDy X -Gsk3a GSK3A Q2NL51 mouse PPAR-alpha 19013 P23204 Ppara mouse S280 1867858200 FHCCQCMsVETVTEL Hormone_recep X -BRSK1 BRSK1 Q8TDC3 human ERC2 259269 Q8K3M6 Erc2 rat S45 4740442 GGTGKTLsMENIQSL X -BRSK1 BRSK1 Q8TDC3 human Tau iso8 4137 P10636-8 MAPT human S262 447930 NVKskIGstENLkHQ Tubulin-binding X -BRSK1 BRSK1 Q8TDC3 human TUBG1 7283 P23258 TUBG1 human S385 34424909 MANHTSIsSLFERTC Tubulin_C X -BRSK1 BRSK1 Q8TDC3 human Tau iso8 4137 P10636-8 MAPT human S356 449104 rVQskIGsLDNItHV Tubulin-binding X -BRSK1 BRSK1 Q8TDC3 human TUBG1 7283 P23258 TUBG1 human S131 10045600 READGsDsLEGFVLC Tubulin X -HASPIN Haspin Q8TF76 human H3 8350 P68431 H3C1 human T3 455678 _____ArtkQtArks Histone X X 9714; 13576 -HASPIN Haspin Q8TF76 human H3 360198 P68433 H3c1 mouse T3 455678 _____ARtkQTARks Histone X 9714; 13576 -Map2k1 MEK1 P31938 mouse MyoD 17927 P10085 Myod1 mouse Y156 18755302 ILRNAIRyIEGLQAL HLH X -Map2k1 MEK1 P31938 mouse ERK2 26413 P63085 Mapk1 mouse Y185 447594 HtGFLtEyVAtRWYR Pkinase X X 9106; 4370; 4374; 9101; 4375; 4376; 4377; 3510; 5726; 88569; 13214; 13148; 70235; 9488; 89967; 8544; 14196; 14227; 14095; 14474; 75165; 98168; 33370; 54240; 15892; 45899; 55088; 9524; 69217; 48735 -Map2k1 MEK1 P31938 mouse ERK1 26417 Q63844 Mapk3 mouse T203 447542 HDHtGFLtEyVAtRW Pkinase X X 9106; 4370; 4374; 9101; 4375; 4376; 4377; 3510; 5726; 88569; 13214; 13148; 70235; 9488; 89967; 8544; 14196; 14227; 14095; 14474; 75165; 98168; 33370; 54240; 15892; 45899; 55088; 9524; 69217; 48735 -Map2k1 MEK1 P31938 mouse ERK2 26413 P63085 Mapk1 mouse T183 447593 HDHtGFLtEyVAtRW Pkinase X X 9106; 4370; 4374; 9101; 4375; 4376; 4377; 3510; 5726; 88569; 13214; 13148; 70235; 9488; 89967; 8544; 14196; 14227; 14095; 14474; 75165; 98168; 33370; 54240; 15892; 45899; 55088; 9524; 69217; 48735 -Map2k1 MEK1 P31938 mouse ERK1 26417 Q63844 Mapk3 mouse Y205 447543 HtGFLtEyVAtRWyR Pkinase X X 9106; 4370; 4374; 9101; 4375; 4376; 4377; 3510; 5726; 88569; 13214; 13148; 70235; 9488; 89967; 8544; 14196; 14227; 14095; 14474; 75165; 98168; 33370; 54240; 15892; 45899; 55088; 9524; 69217; 48735 -Cdk5 CDK5 Q03114 rat MEF2D 81518 O89038 Mef2d rat S430 449407 SIKSEPVsPSRERSP X X -Cdk5 CDK5 Q03114 rat SYNJ1 iso5 85238 Q62910-5 Synj1 rat S1144 450679 KEFGAPKsPGTARKD X -Cdk5 CDK5 Q03114 rat APP iso4 351 P05067-4 APP human T668 448523 VEVDAAVtPEERHLs APP_amyloid X -Cdk5 CDK5 Q03114 rat HER3 29496 Q62799 Erbb3 rat T871 451841 LLHSEAKtPIKWMAL PK_Tyr_Ser-Thr X X -Cdk5 CDK5 Q03114 rat SEPT5 116728 Q9JJM9 Septin5 rat S327 454379 tQDSRMEsPIPILPL X -Cdk5 CDK5 Q03114 rat Cortactin 60465 A6HYF4 Cttn rat T219 15418706 GFEYQGKtEKHESQk HS1_rep X -Cdk5 CDK5 Q03114 rat MAP2 iso2 25595 P15146-2 Map2 rat S136 448323 ETVNLPPsPPPSPAS X 4541 -Cdk5 CDK5 Q03114 rat NMDAR2A 24409 Q00959 Grin2a rat S1232 448260 sGHFtMRsPFkCDAC NMDAR2_C X X -Cdk5 CDK5 Q03114 rat nestin iso2 25491 P21263-2 Nes rat T1495 449819 GETLPDStPLGLYLR X -Cdk5 CDK5 Q03114 rat SYN3 27204 Q8JZP2 Syn3 mouse S404 482763 VPGATVPsPLRPWGP X -Cdk5 CDK5 Q03114 rat nestin iso2 25491 P21263-2 Nes rat T316 449820 AENSRLQtPGRGSQA X X -Cdk5 CDK5 Q03114 rat nNOS 24598 P29476 Nos1 rat S293 56689901 QSPTKNGsPSRCPRF X -Cdk5 CDK5 Q03114 rat DYN1 140694 P21575 Dnm1 rat S774 450205 SVPAGRRsPTSsPTP X X -Cdk5 CDK5 Q03114 rat FZR1 51343 Q9UM11 FZR1 human S163 4661904 kSQKLLRsPRKPTRK X -Cdk5 CDK5 Q03114 rat Cortactin 60465 A6HYF4 Cttn rat T145 41425400 GFEYQGktEKHASQK HS1_rep X -Cdk5 CDK5 Q03114 rat PKLR iso2 24651 P12928-2 Pklr rat S113 31084572 ATESFATsPLSYRPV PK X -Cdk5 CDK5 Q03114 rat SEPT5 116728 Q9JJM9 Septin5 rat S161 2753800 HCCLYFIsPFGHGLR Septin X -Cdk5 CDK5 Q03114 rat SYNJ1 85238 Q62910 Synj1 rat S1160 450679 REMEAPKsPGTARKD X -Cdk5 CDK5 Q03114 rat HER2 24337 P06494 Erbb2 rat S1176 451842 LERPKTLsPGKNGVV X X -Cdk5 CDK5 Q03114 rat MAP2 25595 P15146 Map2 rat S136 448323 ETVNLPPsPPPsPAS X 4541 -Cdk5 CDK5 Q03114 rat FZR1 51343 Q9UM11 FZR1 human T121 3827860 DRRLQPstPEKkGLF X -Cdk5 CDK5 Q03114 rat KIF11 F1MAB8 Kif11 rat T926 448410 LDIPTGMtPERKNYL Microtub_bind X -Cdk5 CDK5 Q03114 rat JNK3 25272 P49187 Mapk10 rat T131 448033 ISLLNVFtPQKTLEE Pkinase X X -Cdk5 CDK5 Q03114 rat HER3 29496 Q62799 Erbb3 rat S1120 451840 RSRSRSRsPRPRGDS X X -Cdk5 CDK5 Q03114 rat WAVE2 313024 Q5FWU0 Wasf2 rat S137 4258800 PPPLNNLsPYRDDGK X -Cdk5 CDK5 Q03114 rat FZR1 51343 Q9UM11 FZR1 human S40 3215931 PAssPVssPsKHGDR X -Cdk5 CDK5 Q03114 rat TRPV1 83810 O35433 Trpv1 rat T406 473576 IAYSSSEtPNRHDML X X -Cdk5 CDK5 Q03114 rat SYN1 24949 P09951 Syn1 rat S551 448377 ARPPAsPsPQRQAGP X -Cdk5 CDK5 Q03114 rat AP2M1 116563 P84092 Ap2m1 rat S45 2048345 HARQQVRsPVTNIAR Clat_adaptor_s X X -Cdk5 CDK5 Q03114 rat DBN1 81653 Q07266 Dbn1 rat S142 452446 NGLARLSsPVLHRLR X -Cdk5 CDK5 Q03114 rat MAP2 iso3 25595 P15146-3 Map2 rat S136 448323 ETVNLPPsPPPSPAS X 4541 -Cdk5 CDK5 Q03114 rat CDK16 18555 Q04735 Cdk16 mouse S95 453454 tssDEVQsPVRVRMR X -Cdk5 CDK5 Q03114 rat PKAR2B 24679 P12369 Prkar2b rat T69 10941783 GAAAGGGtPsKGVNF X -Cdk5 CDK5 Q03114 rat SOX6 20679 P40645 Sox6 mouse T119 4706790 MNSVTFGtPERRKGs X X -Cdk5 CDK5 Q03114 rat Huntingtin 29424 P51111 Htt rat S1150 465621 LTNPPSLsPIRRKGK X -Cdk5 CDK5 Q03114 rat KIF13B 305967 Q70AM4 Kif13b rat T506 27145806 PEGQVMLtPQKNTRT FHA X -Cdk5 CDK5 Q03114 rat CACNA1D 29716 P27732 Cacna1d rat S1947 1827354811 IGYDsRRsPRRRLLP CAC1F_C X X -Cdk5 CDK5 Q03114 rat TH 25085 P04177 Th rat S31 448544 KQAEAVtsPRFIGRR TOH_N X 3370; 13041 -Cdk5 CDK5 Q03114 rat Huntingtin 29424 P51111 Htt rat S1170 465620 EQTSTPMsPKKGGEA X -Cdk5 CDK5 Q03114 rat PPP1CA 24668 P62138 Ppp1ca rat T320 448686 NPGGRPItPPRNSAK X -Cdk5 CDK5 Q03114 rat DYN1 140694 P21575 Dnm1 rat S778 450206 GRRsPTSsPTPQRRA X X -Cdk5 CDK5 Q03114 rat APP iso2 54226 P08592-2 App rat T668 448523 VEVDAAVtPEERHLS APP_amyloid X X 3823; 6986 -Cdk5 CDK5 Q03114 rat gephyrin 64845 Q03555 Gphn rat S283 2020113 LSttPsEsPRAQAts X X -pYV0001 YpkA YP_068414 bacteria G-alpha(q) 2776 P50148 GNAQ human S53 482964 GTGEsGksTFIKQMR G-alpha X -IKBKB IKKB O14920 human CYLD 1540 Q9NQC7 CYLD human S432 12173909 KMPNTNGsIGHsPLs CYLD_phos_site X X -IKBKB IKKB O14920 human PUMA 27113 Q9BXH1 BBC3 human S106 18610002 LAEQHLEsPVPSAPG PUMA X -IKBKB IKKB O14920 human IkB-alpha 18035 Q9Z1E3 Nfkbia mouse S32 448203 LVDDRHDsGLDsMKD X X 5210; 2859; 9246; 5209 -IKBKB IKKB O14920 human NFkB-p105 4790 P19838 NFKB1 human S923 447769 DELRDSDsVCDsGVE X -IKBKB IKKB O14920 human IKKG 16151 O88522 Ikbkg mouse S375 449755 HsFHLALsNQRRsPP X -IKBKB IKKB O14920 human IRF3 3661 Q14653 IRF3 human T404 449031 NsHPLsLtsDQYKAY X -IKBKB IKKB O14920 human IKKB 16150 O88351 Ikbkb mouse S181 447489 DQGsLCTsFVGTLQy Pkinase X 2697; 2694; 14938; 92255; 36516; 36214 -IKBKB IKKB O14920 human Fos 2353 P01100 FOS human S308 7388000 ADWEPLHsGSLGMGP X -IKBKB IKKB O14920 human TNFAIP3 21929 Q60769 Tnfaip3 mouse S381 487535 EPSTPQLsLMDIKCE X -IKBKB IKKB O14920 human COPS5 10987 Q92905 COPS5 human S201 1827354807 kPPDEGPsEyQtIPL X X -IKBKB IKKB O14920 human p63 8626 Q9H3D4 TP63 human S43 27937107 yRSTMSQsTQtNEFL X -IKBKB IKKB O14920 human TSC1 7248 Q92574 TSC1 human S487 5277800 AAIsRELsEItTAEA Hamartin X X -IKBKB IKKB O14920 human Bcl-10 8915 O95999 BCL10 human S138 470125 NNLsRsNsDEsNFsE X X -IKBKB IKKB O14920 human TNF-R1 7132 P19438 TNFRSF1A human S381 20831307 FVRRLGLsDHEIDRL Death X X -IKBKB IKKB O14920 human CYLD 1540 Q9NQC7 CYLD human S439 12173911 sIGHsPLsLsAQsVM CYLD_phos_site X X -IKBKB IKKB O14920 human PUMA 27113 Q9BXH1 BBC3 human S96 18610001 RPDGPQPsLSLAEQH PUMA X -IKBKB IKKB O14920 human TNFAIP3 7128 P21580 TNFAIP3 human S381 487535 EPsVPQLsLMDVKCE X X 63523 -IKBKB IKKB O14920 human AMPKA1 105787 Q5EG47 Prkaa1 mouse T183 448786 sDGEFLRtsCGsPNY Pkinase X X 2535; 2531; 4188; 5256; 50081; 74281 -IKBKB IKKB O14920 human RAPGEF2 9693 Q9Y4G8 RAPGEF2 human S1254 30995202 GsWTSCSsGsHDNIQ X X -IKBKB IKKB O14920 human MTURN 222166 Q8N3F0 MTURN human S58 149319100 GDNFHVWsESEDCLP DUF4581 X -IKBKB IKKB O14920 human CYLD 1540 Q9NQC7 CYLD human S436 12173907 TNGsIGHsPLsLsAQ CYLD_phos_site X X -IKBKB IKKB O14920 human IRF3 3661 Q14653 IRF3 human S398 449029 VDLHIsNsHPLsLts X -IKBKB IKKB O14920 human MCPIP1 230738 Q5D1E7 Zc3h12a mouse S435 22730005 TSQECLDsGIGsLES X -IKBKB IKKB O14920 human IKKG 8517 Q9Y6K9 IKBKG human S43 449037 PAMLHLPsEQGAPEt X X -IKBKB IKKB O14920 human IKKG 8517 Q9Y6K9 IKBKG human S68 1226900 LRDAIRQsNQILRER NEMO X -IKBKB IKKB O14920 human NFkB-p65 5970 Q04206 RELA human S536 447800 sGDEDFSsIADMDFS X X 4887; 3036; 3031; 4886; 3033; 4025; 5733; 13346; 76778; 31553; 80477; 73992; 87672; 83962 -IKBKB IKKB O14920 human MAVS 57506 Q7Z434 MAVS human S442 58984003 CFEDLAIsASTSLGM X X -IKBKB IKKB O14920 human NFkB-p65 5970 Q04206 RELA human S468 451145 AVFTDLAsVDNsEFQ X X 3039 -IKBKB IKKB O14920 human DOK1 1796 Q99704 DOK1 human S450 454885 sHNsALysQVQKSGA X -IKBKB IKKB O14920 human SNAP23 20619 O09044 Snap23 mouse S95 455262 NRTkNFEsGKNYkAt SNAP-25 X X -IKBKB IKKB O14920 human EDC4 23644 Q6P2E9 EDC4 human S583 4271998 PAPADFLsLssEtKP X -IKBKB IKKB O14920 human Bcl-10 8915 O95999 BCL10 human S136 15402376 AtNNLsRsNsDEsNF X X -IKBKB IKKB O14920 human PFKFB3 5209 Q16875 PFKFB3 human S269 58109402 QGRIGGDsGLSsRGK His_Phos_1 X X -IKBKB IKKB O14920 human Bcl-3 602 P20749 BCL3 human S454 31867760 PsPAPGGs_______ X -IKBKB IKKB O14920 human ASB8 140461 Q9H765 ASB8 human S31 1868140200 RTIAAIRsFPHDNVE Ank_2 X -IKBKB IKKB O14920 human Bcl-10 8915 O95999 BCL10 human S144 15408027 NsDEsNFsEkLRAST X X -IKBKB IKKB O14920 human TSC1 7248 Q92574 TSC1 human S511 3208191 DsPFyRDsLPGsQRK Hamartin X X -IKBKB IKKB O14920 human RPS3 6188 P23396 RPS3 human S209 9765788 kPLPDHVsIVEPkDE X -IKBKB IKKB O14920 human Huntingtin 3064 P42858 HTT human S16 12056100 kAFEsLksFQQQQQQ X X -IKBKB IKKB O14920 human IRF3 3661 Q14653 IRF3 human S402 449030 IsNsHPLsLtsDQYK X -IKBKB IKKB O14920 human IKKB 3551 O14920 IKBKB human S258 31849417 GTVKFsssLPyPNNL Pkinase X X -IKBKB IKKB O14920 human optineurin 10133 Q96CV9 OPTN human S513 21214714 FEDGGRQsLMEMQsR X -IKBKB IKKB O14920 human Myc 4609 P01106 MYC human S82 4967400 PLsPsRRsGLCsPSy Myc_N X -IKBKB IKKB O14920 human COPS5 10987 Q92905 COPS5 human T205 1827354804 EGPsEyQtIPLNkIE X X -IKBKB IKKB O14920 human NFkB-p65 5970 Q04206 RELA human S311 449966 RtyEtFksIMkksPF X -IKBKB IKKB O14920 human IKKG 16151 O88522 Ikbkg mouse S369 448798 LPAPAHHsFHLALsN X -IKBKB IKKB O14920 human NFkB-p65 5970 Q04206 RELA human S42 25302155 RYkCEGRsAGsIPGE RHD_DNA_bind X -IKBKB IKKB O14920 human IkB-alpha 4792 P25963 NFKBIA human S32 448203 LLDDRHDsGLDsMkD X X 5210; 2859; 9246; 5209 -IKBKB IKKB O14920 human IKKG 8517 Q9Y6K9 IKBKG human S85 458399 ELLHFQAsQREEKEF NEMO X -IKBKB IKKB O14920 human FOXO3A 2309 O43524 FOXO3 human S644 451438 GLDFNFDsLISTQNV FOXO-TAD X X -IKBKB IKKB O14920 human REL 5966 Q04864 REL human S557 480318 SNTTVFVsQSDAFEG X -IKBKB IKKB O14920 human IRF5 3663 Q13568 IRF5 human S446 26389901 DsIRLQIsNPDLKDR X X -IKBKB IKKB O14920 human NFkB-p105 4790 P19838 NFKB1 human S927 447770 DSDsVCDsGVETsFR X X -IKBKB IKKB O14920 human Huntingtin 15194 P42859 Htt mouse S13 10206805 kLMkAFEsLksFQQQ X -IKBKB IKKB O14920 human DOK1 1796 Q99704 DOK1 human S446 454884 sGIKsHNsALysQVQ X -IKBKB IKKB O14920 human CYLD 1540 Q9NQC7 CYLD human S441 12173908 GHsPLsLsAQsVMEE CYLD_phos_site X X -IKBKB IKKB O14920 human NFkB-p65 5970 Q04206 RELA human S131 477907 RDLEQAIsQRIQtNN RHD_DNA_bind X -IKBKB IKKB O14920 human Myc 4609 P01106 MYC human S86 449991 sRRsGLCsPSyVAVt Myc_N X -IKBKB IKKB O14920 human NFkB-p65 5970 Q04206 RELA human S45 25302163 CEGRsAGsIPGERST RHD_DNA_bind X -IKBKB IKKB O14920 human KIF2A iso1 16563 P28740-1 Kif2a mouse S456 23119260 EGAEINKsLLALKEC Kinesin X -IKBKB IKKB O14920 human p73 7161 O15350 TP73 human S471 18944909 GEMSSSHsAQSMVSG X X -IKBKB IKKB O14920 human p63 8626 Q9H3D4 TP63 human S51 28802100 TQtNEFLsPEVFQHI X -IKBKB IKKB O14920 human IkB-alpha 18035 Q9Z1E3 Nfkbia mouse S36 448204 RHDsGLDsMKDEEYE X X 5210; 9246 -IKBKB IKKB O14920 human NFkB-p65 5970 Q04206 RELA human S261 56850201 tPPYADPsLQAPVRV RHD_dimer X -IKBKB IKKB O14920 human DOK1 1796 Q99704 DOK1 human S439 454882 EPGtATGsGIKsHNs X -IKBKB IKKB O14920 human IkB-alpha 4792 P25963 NFKBIA human S36 448204 RHDsGLDsMkDEEyE X X 5210; 9246 -IKBKB IKKB O14920 human NKX3-2 12020 P97503 Nkx3-2 mouse S148 20473603 EAPVRsDsEMSASVS X -IKBKB IKKB O14920 human RELB 5971 Q01201 RELB human S472 36392502 DFFSGTVsLPGLEPP RelB_transactiv X X -IKBKB IKKB O14920 human IGPR-1 126259 Q96BF3 TMIGD2 human S220 14160579 GKDQRGQsIyStSFP X X -IKBKB IKKB O14920 human NFkB-p105 4790 P19838 NFKB1 human S80 1869465801 sSEKNKKsYPQVKIC RHD_DNA_bind X X -IKBKB IKKB O14920 human Huntingtin 3064 P42858 HTT human S13 10206805 kLMkAFEsLksFQQQ X X -IKBKB IKKB O14920 human EDC4 23644 Q6P2E9 EDC4 human S855 56660920 GLQEKHKsLAFHRPP X -IKBKB IKKB O14920 human p16-INK4A 1029 P42771 CDKN2A human S8 448830 MEPAAGssMEPSADW X X -IKBKB IKKB O14920 human IRF3 3661 Q14653 IRF3 human S396 449028 NtVDLHIsNsHPLsL X 4947; 29047; 83611; 10327; 53539; 81093; 52270; 61166 -IKBKB IKKB O14920 human IKKG 8517 Q9Y6K9 IKBKG human S31 449036 QDVLGEEsPLGKPAM X -IKBKB IKKB O14920 human CYLD 1540 Q9NQC7 CYLD human S568 1874990002 LAFGGYLsEVVEENT X -IKBKB IKKB O14920 human EDC4 23644 Q6P2E9 EDC4 human S107 23101593 IVASsDssISskARG X -IKBKB IKKB O14920 human MCPIP1 230738 Q5D1E7 Zc3h12a mouse S439 22730006 CLDsGIGsLESQMSE X -IKBKB IKKB O14920 human NKX3-2 12020 P97503 Nkx3-2 mouse S146 20473604 EEEAPVRsDsEMSAS X -IKBKB IKKB O14920 human NFkB-p65 19697 Q04207 Rela mouse S545 25302159 MDFSALLsQISS___ X -IKBKB IKKB O14920 human FOXO1A 2308 Q12778 FOXO1 human S319 449113 TFRPRtssNAstIsG X X 2486 -IKBKB IKKB O14920 human STAT1 6772 P42224 STAT1 human T749 56654462 EFDsMMNtV______ X -IKBKB IKKB O14920 human NKX3-2 12020 P97503 Nkx3-2 mouse S168 20473602 RGEDDSVsPGGARVP X -IKBKB IKKB O14920 human CYLD 74256 Q80TQ2 Cyld mouse S414 4745557 SSENRFHsLPFsLtK CYLD_phos_site X -IKBKB IKKB O14920 human CYLD 1540 Q9NQC7 CYLD human S444 12173910 PLsLsAQsVMEELNT CYLD_phos_site X X -IKBKB IKKB O14920 human CYLD 1540 Q9NQC7 CYLD human S422 4745563 RFHsLPFsLtKMPNT CYLD_phos_site X X -IKBKB IKKB O14920 human AMPKA1 105787 Q5EG47 Prkaa1 mouse S184 3195152 DGEFLRtsCGsPNYA Pkinase X -IKBKB IKKB O14920 human PUMA 27113 Q9BXH1 BBC3 human S10 18610000 RARQEGSsPEPVEGL PUMA X -IKBKB IKKB O14920 human HSC70 15481 P63017 Hspa8 mouse S85 31857927 FDDAVVQsDMkHWPF HSP70 X X -IKBKB IKKB O14920 human SNAP23 20619 O09044 Snap23 mouse S120 455263 NVVskQPsRITNGQP SNAP-25 X X -IKBKB IKKB O14920 human EDC4 23644 Q6P2E9 EDC4 human S405 1337911000 PDIFSSVsVPPSLKV Ge1_WD40 X -IKBKB IKKB O14920 human Bcl-10 8915 O95999 BCL10 human S141 4786673 sRsNsDEsNFsEkLR X X -IKBKB IKKB O14920 human IRS1 3667 P35568 IRS1 human S312 447558 tEsItAtsPAsMVGG X 2381 -IKBKB IKKB O14920 human IKKB 3551 O14920 IKBKB human S177 447492 AkELDQGsLCtsFVG Pkinase X X 2078; 2697; 2694; 14938; 92255; 36516; 36214 -IKBKB IKKB O14920 human NFkB-p65 19697 Q04207 Rela mouse S534 447800 sGDEDFssIADMDFS X X 4887; 3036; 3031; 4886; 3033; 4025; 5733; 13346; 76778; 31553; 80477; 73992; 87672; 83962 -IKBKB IKKB O14920 human AMPKA1 105787 Q5EG47 Prkaa1 mouse T388 7712505 EtPRARHtLDELNPQ X -IKBKB IKKB O14920 human IKKB 3551 O14920 IKBKB human S181 447489 DQGsLCtsFVGTLQy Pkinase X X 2697; 2694; 14938; 92255; 36516; 36214 -IKBKB IKKB O14920 human PIK3R1 18708 P26450 Pik3r1 mouse S690 25018700 EPYNLYSsLKELVLH SH2 X -IKBKB IKKB O14920 human NFkB-p65 19697 Q04207 Rela mouse S467 451145 GVFTDLAsVDNSEFQ X 3039 -IKBKB IKKB O14920 human IKKG 8517 Q9Y6K9 IKBKG human S376 448798 PPAPAyLssPLALPs X 2689 -IKBKB IKKB O14920 human CYLD 1540 Q9NQC7 CYLD human S418 4745557 TTENRFHsLPFsLtK CYLD_phos_site X X 4500 -IKBKB IKKB O14920 human NFkB-p105 4790 P19838 NFKB1 human S932 447771 CDsGVETsFRKLsFt X 4806; 4808; 41317 -IKBKB IKKB O14920 human Huntingtin 3064 P42858 HTT human T3 10206804 _____MAtLEkLMkA X -IKBKB IKKB O14920 human SNAP23 8773 O00161 SNAP23 human S95 455262 NRTkNFEsGkAykTt SNAP-25 X -IKBKB IKKB O14920 human Bcl-10 8915 O95999 BCL10 human S134 467254 DGAtNNLsRsNsDEs X X -IKBKB IKKB O14920 human DOK1 1796 Q99704 DOK1 human S443 454883 ATGsGIKsHNsALys X -IKBKB IKKB O14920 human IRF3 3661 Q14653 IRF3 human S405 449032 sHPLsLtsDQYKAYL X -Prkaca PKACA P27791 rat GSK3B 84027 P18266 Gsk3b rat S9 449111 SGRPRTTsFAESCKP X 9336; 9331; 9327; 9323; 9322; 9325; 5558; 8566; 79774; 8466; 25462; 14026; 14332; 14310; 14630 -Prkaca PKACA P27791 rat mGluR2 24415 P31421 Grm2 rat S843 450654 GSAAPRAsANLGQGS X X -Prkaca PKACA P27791 rat PPP1R1A 58977 P19103 Ppp1r1a rat T35 447759 QIRRRRPtPATLVLT DARPP-32 X -Prkaca PKACA P27791 rat RKIP 29542 P31044 Pebp1 rat S51 3189670 TQVMNRPssIsWDGL PBP X -Prkaca PKACA P27791 rat Merlin 25744 Q63648 Nf2 rat S514 448282 DTDMKRLsMEIEKEK ERM_C X 9163; 13281 -Prkaca PKACA P27791 rat PLCB3 29322 Q99JE6 Plcb3 rat S1105 448448 LDRKRNNsISEAKTR PLC-beta_C X 2484 -Prkaca PKACA P27791 rat phosducin 287007 P19632 PDC cow S73 451205 ERFSRKMsVQEYELI Phosducin X -Prkaca PKACA P27791 rat NHE3 24784 P26433 Slc9a3 rat S552 450899 AEGERRGsLAFIRSP X -Prkaca PKACA P27791 rat Nur77 79240 P22829 Nr4a1 rat S350 447942 GRRGRLPsKPKQPPD X 5095 -Prkaca PKACA P27791 rat RIMS1 84556 Q9JIR4 Rims1 rat S413 450481 ARHERRHsDVALPHT X -Prkaca PKACA P27791 rat GluR6 54257 P42260 Grik2 rat S856 478416 NAQLEKRsFCSAMVE X -Prkaca PKACA P27791 rat GLUT2 25351 P12336 Slc2a2 rat S503 451346 EFRKKsGsAPPRKAt X X -Prkaca PKACA P27791 rat AMPKA1 105787 Q5EG47 Prkaa1 mouse S496 450431 AtPQRsGsIsNYRsC AdenylateSensor X 4185; 4184; 2537 -Prkaca PKACA P27791 rat NFE2L1 4779 Q14494 NFE2L1 human S599 454236 PSALKKGsKEKQADF X -Prkaca PKACA P27791 rat BAD 64639 O35147 Bad rat S156 447863 GRELRRMsDEFEGSF Bcl-2_BAD X -Prkaca PKACA P27791 rat PDE3B 29516 Q63085 Pde3b rat S302 449873 GKMFRRPsLPCISRE X -Prkaca PKACA P27791 rat CBX3 297093 Q5RJK5 Cbx3 rat S93 457001 KDGTKRKsLsDsESD X X -Prkaca PKACA P27791 rat NFL 83613 P19527 Nefl rat S42 457402 TARsAySsySAPVsS Filament_head X -Prkaca PKACA P27791 rat STEP iso3 84867 P54829-3 PTPN5 human S221 448294 GLQERRGsNVSLTLD X X -Prkaca PKACA P27791 rat STMN1 29332 P13668 Stmn1 rat S63 448557 AAEERRKsHEAEVLk Stathmin X -Prkaca PKACA P27791 rat PHKG1 100009297 P00518 PHKG1 rabbit S82 455919 VDILRKVsGHPNIIQ Pkinase X -Prkaca PKACA P27791 rat HSL 25330 P15304 Lipe rat S960 450195 GFHPRRssQGVLHMP Abhydrolase_3 X 4126 -Prkaca PKACA P27791 rat ACC1 60581 P11497 Acaca rat S77 448291 LAFHMRSsMsGLHLV X -Prkaca PKACA P27791 rat rabphilin 3A 171039 P47709 Rph3a rat S234 455904 GPPTRRAsEARMSTT X -Prkaca PKACA P27791 rat KCNN4 65206 Q9QYW1 Kcnn4 rat T327 452144 AWMYYKHtRRKDsRA CaMBD X -Prkaca PKACA P27791 rat IP3R3 3710 Q14573 ITPR3 human S916 468030 GGKNVRRsIQGVGHM X -Prkaca PKACA P27791 rat FBPase 24362 P19112 Fbp1 rat S357 449856 AREsPVHsICDELF_ X -Prkaca PKACA P27791 rat NFL 83613 P19527 Nefl rat S50 457403 ySAPVsSsLSVRRsY Filament_head X -Prkaca PKACA P27791 rat SNAP-25 25012 P60881 Snap25 rat T138 449875 GGFIRRVtNDARENE SNAP-25 X -Prkaca PKACA P27791 rat PIK3R1 282307 P23727 PIK3R1 cow S83 471075 YIGRKKIsPPtPKPR X -Prkaca PKACA P27791 rat NKX2-1 25628 P23441 Nkx2-1 rat T9 451108 SMSPKHTtPFsVSDI X -Prkaca PKACA P27791 rat TP2 24840 P11101 Tnp2 rat S109 450902 HRAkRRSsGRRYK__ TP2 X -Prkaca PKACA P27791 rat mGluR3 24416 P31422 Grm3 rat S845 450252 RLHLNRFsVSGTATT X -Prkaca PKACA P27791 rat GluR4 29629 P19493 Gria4 rat S862 448810 TRNKARLsITGSVGE X -Prkaca PKACA P27791 rat SCN2A 24766 P04775 Scn2a rat S610 451195 DNDSRRDsLFVPHRH Na_trans_cytopl X -Prkaca PKACA P27791 rat PAH 24616 P04176 Pah rat S16 449074 GVLSRKLsDFGQETS X -Prkaca PKACA P27791 rat NFM 24588 P12839 Nefm rat S2 457406 ______MsYTLDSLG X -Prkaca PKACA P27791 rat NFL 83613 P19527 Nefl rat S436 457404 QSSsyLMsARAFPAy X -Prkaca PKACA P27791 rat SCN2A 24766 P04775 Scn2a rat S554 452015 TYEKRFssPHQsLLS X -Prkaca PKACA P27791 rat NFkB-p65 309165 Q7TQN4 Rela rat S276 447798 SMQLRRPsDRELSEP RHD_dimer X -Prkaca PKACA P27791 rat Tau iso8 4137 P10636-8 MAPT human S262 447930 NVKskIGstENLkHQ Tubulin-binding X -Prkaca PKACA P27791 rat FBPase 24362 P19112 Fbp1 rat S342 449869 DKAKsRPsLPLPQSR X -Prkaca PKACA P27791 rat SCN5A 25665 P15389 Scn5a rat S526 451568 TSMRPRSsRGsIFTF Na_trans_cytopl X X -Prkaca PKACA P27791 rat AQP2 25386 P34080 Aqp2 rat S269 3339002 PQsLPRGskA_____ X -Prkaca PKACA P27791 rat HSL 25330 P15304 Lipe rat S863 448803 LTESMRRsVsEAALA X -Prkaca PKACA P27791 rat EEF2K 25435 P70531 Eef2k rat S365 447827 sPRIRTLsGSRPPLL X -Prkaca PKACA P27791 rat SYN1 24949 P09951 Syn1 rat S9 448378 NYLRRRLsDSNFMAN Synapsin_N X 2311; 67605 -Prkaca PKACA P27791 rat AMPKA1 65248 P54645 Prkaa1 rat S496 450431 AtPQRSGsISNYRSC AdenylateSensor X 4185; 4184; 2537 -Prkaca PKACA P27791 rat SYN3 29130 O70441 Syn3 rat S9 449840 NFLRRRLsDSSFVAN Synapsin_N X -Prkaca PKACA P27791 rat DNAJC5 79130 P60905 Dnajc5 rat S10 448129 DQRQRsLsTsGEsLY X X -Prkaca PKACA P27791 rat NFM 24588 P12839 Nefm rat S609 448044 AKsPVPKsPVEEVKP X -Prkaca PKACA P27791 rat Kir5.1 29719 P52191 Kcnj16 rat S417 451508 LNRISMEsQM_____ X -Prkaca PKACA P27791 rat HSL 25330 P15304 Lipe rat S959 450194 DGFHPRRssQGVLHM Abhydrolase_3 X -Prkaca PKACA P27791 rat SLC38A3 252919 Q9JHZ9 Slc38a3 rat S52 19001700 KGFLQQSsSKEPHFT X -Prkaca PKACA P27791 rat CREB iso1 81646 P15337-1 Creb1 rat S133 448228 EILsRRPsYRkILND pKID X X 9187; 9196; 9198; 4095; 14228; 14001; 39561; 80120; 44864; 54960; 95995 -Prkaca PKACA P27791 rat mGluR2 24415 P31421 Grm2 rat S675 452085 AQRPRFIsPASQVAI 7tm_3 X -Prkaca PKACA P27791 rat PDE1A 281969 P14100 PDE1A cow S120 451186 EEKPRFRsIVHVVQA PDEase_I_N X -Prkaca PKACA P27791 rat SCN2A 24766 P04775 Scn2a rat S573 451193 LFsPrRNsRAsLFNF Na_trans_cytopl X -Prkaca PKACA P27791 rat IPO13 116458 Q9JM04 Ipo13 rat S193 15420334 RKGLVRAsLAVECGA Xpo1 X -Prkaca PKACA P27791 rat Myf-6 25714 P19335 Myf6 rat S221 451240 SSLQRLssIVDSISS X -Prkaca PKACA P27791 rat Kv1.4 25469 P15385 Kcna4 rat S229 457537 FFDRNRPsFDAILYY BTB_2 X -Prkaca PKACA P27791 rat DRP1 114114 O35303 Dnm1l rat S656 483971 VPVARKLsAREQRDC X 4867; 6319 -Prkaca PKACA P27791 rat MYPT1 116670 Q10728 Ppp1r12a rat S669 478658 EVRERRRsYLTPVRD X 3048 -Prkaca PKACA P27791 rat KCNN4 65206 Q9QYW1 Kcnn4 rat S312 452143 YAKEMKEsAARLLQE CaMBD X -Prkaca PKACA P27791 rat GHF-1 25517 P10037 Pou1f1 rat T220 451518 RKRKRRTtISIAAKD Homeodomain X -Prkaca PKACA P27791 rat AQP2 25386 P34080 Aqp2 rat S261 464644 RQsVELHsPQsLPRG X -Prkaca PKACA P27791 rat NFL 83613 P19527 Nefl rat S13 457195 YEPYFSTsYkRRYVE Filament_head X -Prkaca PKACA P27791 rat HSP20 192245 P97541 Hspb6 rat S16 450706 PsWLRRAsAPLPGFS Crystallin X 36519 -Prkaca PKACA P27791 rat BAD 64639 O35147 Bad rat S137 447862 PFRGRsRsAPPNLWA Bcl-2_BAD X 9295; 5286; 4366 -Prkaca PKACA P27791 rat SLC14A2 54302 Q62668 Slc14a2 rat S486 2813501 TVFPRRKsVFHIEWS X -Prkaca PKACA P27791 rat THOP1 64517 P24155 Thop1 rat S644 448213 VGMDYRTsILRPGGS Peptidase_M3 X X -Prkaca PKACA P27791 rat LC3B 81631 Q9GZQ8 MAP1LC3B human T6 14150105 __MPSEktFKQRRTF X -Prkaca PKACA P27791 rat Myf-6 25714 P19335 Myf6 rat S220 451239 SSSLQRLssIVDSIS X -Prkaca PKACA P27791 rat PAK1 29431 P35465 Pak1 rat T422 448177 PEQSKRstMVGTPYW Pkinase X -Prkaca PKACA P27791 rat GLUT2 25351 P12336 Slc2a2 rat S489 451344 VPETKGKsFDEIAAE Sugar_tr X X -Prkaca PKACA P27791 rat H3 291159 Q6LED0 Hist1h2ail1 rat S10 455676 tkQTARkstGGkAPR Histone X X 9701; 9711; 9606; 3465; 3642; 3377; 3475; 3458; 5764; 47398; 8481; 8552; 53348; 29237; 66065; 43185; 64522; 52725 -Prkaca PKACA P27791 rat EEF2K 25435 P70531 Eef2k rat S499 455998 RLHLPRPsAVALEVQ X -Prkaca PKACA P27791 rat GluR1 50592 P19490 Gria1 rat S863 448566 TSTLPRNsGAGASGG X 8084 -Prkaca PKACA P27791 rat STEP iso3 84867 P54829-3 PTPN5 human S160 51170600 PPEDRRQsVSRQPSF X X -Prkaca PKACA P27791 rat IP3R3 3710 Q14573 ITPR3 human S934 475070 MVLsRkQsVFsAPsL X -Prkaca PKACA P27791 rat ACC1 60581 P11497 Acaca rat S1200 448290 IPtLNRMsFASNLNH ACC_central X -Prkaca PKACA P27791 rat HSL 25330 P15304 Lipe rat S865 448804 ESMRRsVsEAALAQP X 4137 -Prkaca PKACA P27791 rat NHE3 24784 P26433 Slc9a3 rat S605 450900 SLEQRRRsIRDTEDM X -Prkaca PKACA P27791 rat dynactin 1 29167 P28023 Dctn1 rat S19 455515 TPSGSRMsTEASARP X X -Prkaca PKACA P27791 rat Survivin 332 O15392 BIRC5 human S20 485776 FLkDHRIstFkNWPF BIR X -Prkaca PKACA P27791 rat CYP3A5 25642 P04800 Cyp3a1 rat S393 451172 GVFMPKGsVVMIPSY p450 X -Prkaca PKACA P27791 rat PKD2 5311 Q13563 PKD2 human S801 15702202 SSLPRPMsSRSFPRs X -Prkaca PKACA P27791 rat CAMKK2 83506 O88831 Camkk2 rat T144 15425433 PRMPRRPtVESHHVS X X -Prkaca PKACA P27791 rat GLUT2 25351 P12336 Slc2a2 rat T510 451347 sAPPRKAtVQMEFLG X X -Prkaca PKACA P27791 rat CACNA1C 12288 Q01815 Cacna1c mouse S1897 455278 ASLGRRAsFHLECLK CAC1F_C X -Prkaca PKACA P27791 rat PLM 5348 O00168 FXYD1 human S88 451425 RssIRRLstRRR___ X -Prkaca PKACA P27791 rat IP3R3 3710 Q14573 ITPR3 human S1832 475071 TTkGRVAsFsIPGss X -Prkaca PKACA P27791 rat SCN2A 24766 P04775 Scn2a rat S623 451196 RHGERRPsNVSQASR Na_trans_cytopl X -Prkaca PKACA P27791 rat GATA4 54254 P46152 Gata4 rat S261 450013 IKPQRRLsASRRVGL X -Prkaca PKACA P27791 rat RYR2 689560 B0LPN4 Ryr2 rat S2021 455603 TIRGRLLsLVEKVTY X -Prkaca PKACA P27791 rat Tau iso8 4137 P10636-8 MAPT human S214 447929 GsRsRtPsLPtPPtR X 77348 -Prkaca PKACA P27791 rat PLM 58971 O08589 Fxyd1 rat S88 451425 RSsIRRLstRRR___ X -Prkaca PKACA P27791 rat Nur77 79240 P22829 Nr4a1 rat S340 451513 KEVVRTDsLKGRRGR X -Prkaca PKACA P27791 rat PDE10A iso2 10846 Q9Y233-2 PDE10A human T16 478273 AScFRRLtECFLSPS X -Prkaca PKACA P27791 rat NFM 24588 P12839 Nefm rat S604 451836 EKPEKAKsPVPKsPV X -Prkaca PKACA P27791 rat phosducin 25343 P20942 Pdc rat S73 451205 ERMSRKMsIQEYELI Phosducin X -Prkaca PKACA P27791 rat SHANK3 59312 Q9JLU4 Shank3 rat S685 3844913 PPPKRAPsTTLTLRS X -Prkaca PKACA P27791 rat PKAR2B 24679 P12369 Prkar2b rat S112 452036 NRFTRRAsVCAEAyN X -Prkaca PKACA P27791 rat HMGCR 101843185 P09610 HMGCR hamster S871 448568 SHMVHNRsKINLQDL X -Prkaca PKACA P27791 rat Stargazin 84347 Q71RJ2 Cacng2 rat T321 451273 NTANRRTtPV_____ X X -Prkaca PKACA P27791 rat RYR2 689560 B0LPN4 Ryr2 rat S2798 448848 yNRTRRIsQTsQVsI X -Prkaca PKACA P27791 rat KCNN4 65206 Q9QYW1 Kcnn4 rat T348 452146 KMLAAIHtFRQVRLK CaMBD X -Prkaca PKACA P27791 rat nAChRA7 25302 Q05941 Chrna7 rat S365 451182 QHKPRRCsLASVELS Neur_chan_memb X -Prkaca PKACA P27791 rat ATP1A1 24211 P06685 Atp1a1 rat S943 451649 ICKTRRNsVFQQGMK Cation_ATPase_C X -Prkaca PKACA P27791 rat TH 25085 P04177 Th rat S40 448545 RFIGRRQsLIEDARK TOH_N X X 2791 -Prkaca PKACA P27791 rat CACNA1C 24239 P22002 Cacna1c rat S1927 455278 ASLGRRAsFHLECLK CAC1F_C X -Prkaca PKACA P27791 rat prolactin 24683 P01237 Prl rat S206 451732 IRCLRRDsHKVDNYL Hormone_1 X -Prkaca PKACA P27791 rat eIF2-beta 100009285 P41035 EIF2S2 rabbit S218 454002 RVGTKKTsFVNFTDI eIF-5_eIF-2B X -Prkaca PKACA P27791 rat neurabin 1 84685 O35867 Ppp1r9a rat S461 455523 ANRKIKFsCAPIKVF PDZ_5 X X -Prkaca PKACA P27791 rat HMGCR 25675 P51639 Hmgcr rat S871 448568 SHMVHNRsKINLQDL X -Prkaca PKACA P27791 rat LC3B 81631 Q9GZQ8 MAP1LC3B human T29 14150106 LIREQHPtkIPVIIE ATG8 X -Prkaca PKACA P27791 rat NPPA 24602 P01161 Nppa rat S128 22689700 PRSLRRSsCFGGRID ANP X -Prkaca PKACA P27791 rat Myf-6 25714 P19335 Myf6 rat S89 451238 CKTCKRKsAPTDRRK Basic X -Prkaca PKACA P27791 rat NFM 24588 P12839 Nefm rat S767 451045 VTNGLDVsPAEEKKG X -Prkaca PKACA P27791 rat SCN2A 24766 P04775 Scn2a rat S687 451194 EIRKRRsssyHVsMD Na_trans_cytopl X -Prkaca PKACA P27791 rat EVL 51466 Q9UI08 EVL human S158 11379602 EsLERRTsATGPILP X -Prkaca PKACA P27791 rat SCN5A 25665 P15389 Scn5a rat S529 451569 RPRSsRGsIFTFRRR Na_trans_cytopl X X -Prkaca PKACA P27791 rat SYN2 29179 Q63537 Syn2 rat S10 449839 NFLRRRLsDSSFIAN Synapsin_N X -Prkaca PKACA P27791 rat STMN2 84510 P21818 Stmn2 rat S97 455607 AAEGRRKsQEAQVLK Stathmin X -Prkaca PKACA P27791 rat AQP2 25386 P34080 Aqp2 rat S264 2238600 VELHsPQsLPRGskA X -Prkaca PKACA P27791 rat NFM 24588 P12839 Nefm rat S667 448045 PDKKKAEsPVKEKAV X -Prkaca PKACA P27791 rat CAMKK1 60341 P97756 Camkk1 rat T108 452083 PRAWRRPtIESHHVA X -Prkaca PKACA P27791 rat TP2 24840 P11101 Tnp2 rat T101 450901 AVRRRKRtHRAkRRS TP2 X -Prkaca PKACA P27791 rat Restin 65201 Q9JK25 Clip1 rat S311 4769833 ASLKRsPsAssLSSM X -Prkaca PKACA P27791 rat C/EBP-beta 24253 P21272 Cebpb rat S105 448425 AKPSKKPsDYGyVsL X 3081 -Prkaca PKACA P27791 rat STEP 29644 P35234 Ptpn5 rat S49 448294 GLQERRGsNVSLTLD X X 5659 -Prkaca PKACA P27791 rat SYN1 281510 P17599 SYN1 cow S9 448378 NYLRRRLsDSNFMAN Synapsin_N X -Prkaca PKACA P27791 rat STMN2 84510 P21818 Stmn2 rat S50 455606 KQINKRAsGQAFELI Stathmin X -Prkaca PKACA P27791 rat STMN1 29332 P13668 Stmn1 rat S16 448554 kELEKRAsGQAFELI Stathmin X 3353 -Prkaca PKACA P27791 rat PDE4B 24626 P14646 Pde4b rat S133 449097 GHSQRREsFLYRSDs X -Prkaca PKACA P27791 rat SYT7 59267 Q62747 Syt7 rat S103 4758666 RRTEPRSsVSDLVNS X -Prkaca PKACA P27791 rat NFM 24588 P12839 Nefm rat S47 457407 SWSRGSPstVSSSYK Filament_head X -Prkaca PKACA P27791 rat GLUT2 25351 P12336 Slc2a2 rat S501 451345 AAEFRKKsGsAPPRK X X -Prkaca PKACA P27791 rat PDE1A 281969 P14100 PDE1A cow S138 457690 VERMYRKsYHMVGLA X -Prkaca PKACA P27791 rat GSK3A 50686 P18265 Gsk3a rat S21 448584 SGRARtssFAEPGGG X 9337; 9316; 9331; 9327; 8452; 8566 -Prkaca PKACA P27791 rat CAMKK1 60341 P97756 Camkk1 rat S458 486077 KSMLRKRsFGNPFEP X -Prkaca PKACA P27791 rat BAD 64639 O35147 Bad rat S113 447860 ETRSRHssYPAGtEE Bcl-2_BAD X 9291; 5284; 9296; 5193; 11865; 94223 -Prkaca PKACA P27791 rat PEX5L 286937 Q925N3 Pex5l rat S237 481412 ALLsRNHsLEEEFER X -Prkaca PKACA P27791 rat AQP2 25386 P34080 Aqp2 rat S256 449854 REVRRRQsVELHsPQ X X -Prkaca PKACA P27791 rat AKAP13 11214 Q12802 AKAP13 human S2733 455336 sVsPKRNsISRTHKD X -Prkaca PKACA P27791 rat C/EBP-beta 24253 P21272 Cebpb rat S240 452156 NNIAVRKsRDKAKMR bZIP_2 X -Prkaca PKACA P27791 rat KCNN4 65206 Q9QYW1 Kcnn4 rat S332 452145 KHtRRKDsRAARRHQ CaMBD X -Prkaca PKACA P27791 rat GluR6 54257 P42260 Grik2 rat S868 478417 MVEELRMsLKCQRRL X -Prkaca PKACA P27791 rat GHF-1 25517 P10037 Pou1f1 rat S115 451519 KQELRRKsKLVEEPI X -Prkaca PKACA P27791 rat PLB 64672 P61016 Pln rat S16 448114 RSAIRRAstIEMPQQ Phospholamban X 8496 -Prkaca PKACA P27791 rat ANP-C 25339 P41740 Npr3 rat T505 15108900 FRKKYRItIERRNHQ X -Prkaca PKACA P27791 rat NFL 83613 P19527 Nefl rat S3 2872003 _____MSsFSYEPYF X -MKNK1 Mnk1 Q9BUB5 human PNPLA8 50640 Q9NP80 PNPLA8 human S511 18638838 ELYRKLGsDVFsQNV Patatin X -MKNK1 Mnk1 Q9BUB5 human SynGAP 240057 F6SEU4 Syngap1 mouse S788 19014968 MDMARLPsPtKEkPP DUF3498 X -MKNK1 Mnk1 Q9BUB5 human EIF4E 13684 P63073 Eif4e mouse T210 450199 TATKSGsttKNRFVV X X -MKNK1 Mnk1 Q9BUB5 human EIF4E 13684 P63073 Eif4e mouse S209 447776 DTATKSGsttKNRFV X X 9741 -MKNK1 Mnk1 Q9BUB5 human PSF 6421 P23246 SFPQ human S283 3182056 EGFkANLsLLRRPGE X -MKNK1 Mnk1 Q9BUB5 human PSF 6421 P23246 SFPQ human S8 25802101 MSRDRFrsrGGGGGG X -MKNK1 Mnk1 Q9BUB5 human hnRNP A1 3178 P09651 HNRNPA1 human S192 456539 EMASAsssQrGrsGs X -MKNK1 Mnk1 Q9BUB5 human hnRNP A1 3178 P09651 HNRNPA1 human S364 455936 yGGssssssyGsGrr X -MKNK1 Mnk1 Q9BUB5 human SPRY2 10253 O43597 SPRY2 human S112 465675 APLSRSIsTVssGsR X X -MKNK1 Mnk1 Q9BUB5 human EIF4E 1977 P06730 EIF4E human S209 447776 DtATksGsttKNRFV X X 9741 -MKNK1 Mnk1 Q9BUB5 human hnRNP A1 3178 P09651 HNRNPA1 human S363 456542 GyGGssssssyGsGr X -MKNK1 Mnk1 Q9BUB5 human hnRNP A1 3178 P09651 HNRNPA1 human S362 456541 GGyGGssssssyGsG X -MKNK1 Mnk1 Q9BUB5 human SPRY2 10253 O43597 SPRY2 human S121 465676 VssGsRSsTRtSTSs X X -MARK4 MARK4 Q96L34 human TNK1 8711 Q13470 TNK1 human S502 483166 RMKGIsRsLEsVLsL X -MARK4 MARK4 Q96L34 human TORC2 74343 Q3U182 Crtc2 mouse S171 454622 sALNRtSsDsALHTs TORC_M X -MARK4 MARK4 Q96L34 human TORC2 74343 Q3U182 Crtc2 mouse S275 3174300 PAMNTGGsLPDLTNL TORC_M X -MARK4 MARK4 Q96L34 human TORC2 74343 Q3U182 Crtc2 mouse S307 454633 PSLSGGNsTTNLTHT TORC_M X -AURKB AurB Q96GD4 human NuMA-1 4926 Q14980 NUMA1 human T2055 472502 MAFsILNtPkkLGNs X 14951 -AURKB AurB Q96GD4 human MgcRacGAP 29127 Q9H0H5 RACGAP1 human S387 449096 ETGLYRIsGCDRTVK RhoGAP X X -AURKB AurB Q96GD4 human HEC1 10403 O14777 NDC80 human T49 474512 kLsINkPtsERkVsL X -AURKB AurB Q96GD4 human SHCBP1 79801 Q8NEM2 SHCBP1 human S634 3206817 QIKKKRLsELGITQA X X -AURKB AurB Q96GD4 human Rb 5925 P06400 RB1 human S780 447978 strPPtLsPIPHIPr Rb_C X 9307; 3590; 8180 -AURKB AurB Q96GD4 human ZWINT 11130 O95229 ZWINT human S262 20765003 MGRDPGVsFkAVGLQ Zwint X X -AURKB AurB Q96GD4 human DNAPK 5591 P78527 PRKDC human S511 7445645 EsEDHRAsGEVRtGk DNA-PKcs_N X -AURKB AurB Q96GD4 human H2B1M 8342 Q99879 H2BC14 human Y83 11173392 EAsrLAHyNkrstIt Histone X -AURKB AurB Q96GD4 human AML2 864 Q13761 RUNX3 human T14 4733089 PSTSRRFtPPsPAFP X -AURKB AurB Q96GD4 human H2B1H 8345 Q93079 H2BC9 human Y83 11173384 EAsrLAHyNkrstIt Histone X -AURKB AurB Q96GD4 human Borealin 55143 Q53HL2 CDCA8 human T278 482837 QICssIRtHK_____ X -AURKB AurB Q96GD4 human H2B1D 3017 P58876 H2BC5 human Y83 11173360 EAsrLAHyNkrstIt Histone X -AURKB AurB Q96GD4 human INCENP 3619 Q9NQS7 INCENP human S72 4172633 RRKKRRIsyVQDENR X -AURKB AurB Q96GD4 human GFAP 2670 P14136 GFAP human S38 449621 LGPGTRLsLARMPPP Filament_head X X -AURKB AurB Q96GD4 human smMLCK 396445 P11799 MYLK chicken S140 41411900 KTPGGRLsVPPVEHR X -AURKB AurB Q96GD4 human HIST2H2BC 337873 Q6DN03 H2BC20P human S78 50780569 ERIAGEAsrLAHyNk Histone X -AURKB AurB Q96GD4 human desmin 1674 P17661 DES human T17 449613 RVssYRRtFGGAPGF Filament_head X X -AURKB AurB Q96GD4 human DEK 7913 P35659 DEK human T67 27777400 KKKVERLtMQVssLQ X -AURKB AurB Q96GD4 human K8 3856 P05787 KRT8 human T6 27777403 __MsIRVtQksykVs Keratin_2_head X -AURKB AurB Q96GD4 human CDCA5 113130 Q96FF9 CDCA5 human S126 20727702 NPEAEsssKEGELDA Sororin X X -AURKB AurB Q96GD4 human Diaphanous-2 iso4 1730 Q17R91 DIAPH2 human S820 18707505 HINNIKPsIIAVTLA FH2 X -AURKB AurB Q96GD4 human MYBBP1A 10514 Q9BQG0 MYBBP1A human S1303 3210687 ARKKARLsLVIRsPs X X -AURKB AurB Q96GD4 human CDCA5 113130 Q96FF9 CDCA5 human T111 469415 ktHsVPAtPtStPVP Sororin X X -AURKB AurB Q96GD4 human Haspin 83903 Q8TF76 HASPIN human S93 3207480 RVPKDRPsLTVtPkR X X -AURKB AurB Q96GD4 human ataxin-10 25814 Q9UBB4 ATXN10 human S12 14159379 rPPPArLsGVMVPAP X X -AURKB AurB Q96GD4 human H2B1C 8347 P62807 H2BC4 human S78 50780190 ErIAGEAsrLAHyNk Histone X -AURKB AurB Q96GD4 human DSN1 79980 Q9H410 DSN1 human S109 3595501 KETNRRksLHPIHQG MIS13 X X -AURKB AurB Q96GD4 human KIF4A 24137 O95239 KIF4A human T799 479906 PPKLRRRtFsLTEVR X X -AURKB AurB Q96GD4 human COBLL1 22837 Q53SF7 COBLL1 human S876 4721016 LQMQKRVsGHyVTSA X -AURKB AurB Q96GD4 human PPHLN1 51535 Q8NEY8 PPHLN1 human S110 476417 RDGFRRksFyssHyA X -AURKB AurB Q96GD4 human RIF1 55183 Q5UIP0 RIF1 human S2205 3201699 VNkVRRVsFADPIyQ X -AURKB AurB Q96GD4 human PLEKHG6 55200 Q3KR16 PLEKHG6 human T544 31834908 SPStRPstPsLEGSQ X X -AURKB AurB Q96GD4 human NuMA-1 4926 Q14980 NUMA1 human T1811 1245323 tRsARRRttQIINIt X -AURKB AurB Q96GD4 human NSUN2 54888 Q08J23 NSUN2 human S139 478355 SRKILRksPHLEkFH X X -AURKB AurB Q96GD4 human KIF20A 10112 O95235 KIF20A human S878 4712595 RILRsRRsPLLKsGP X X -AURKB AurB Q96GD4 human Nlp 22981 Q9Y2I6 NINL human S585 15668108 RLPKNRHsPSWsPDG X X -AURKB AurB Q96GD4 human CKAP2 26586 Q8WWK9 CKAP2 human S628 7603500 FLtPVRRsRRLQEKT CKAP2_C X X -AURKB AurB Q96GD4 human KIF2C 11004 Q99661 KIF2C human S95 451107 IQkQKRRsVNSkIPA X X -AURKB AurB Q96GD4 human desmin 1674 P17661 DES human S60 449614 VyQVsRtsGGAGGLG Filament_head X X -AURKB AurB Q96GD4 human HEC1 10403 O14777 NDC80 human S15 474511 SGGAGRLsMQELrSQ X -AURKB AurB Q96GD4 human NPM1 4869 P06748 NPM1 human S125 459897 AVEEDAEsEDEEEED X X -AURKB AurB Q96GD4 human H3 8350 P68431 H3C1 human T3 455678 _____ArtkQtArks Histone X 9714; 13576 -AURKB AurB Q96GD4 human ATM 472 Q13315 ATM human S1403 22496700 CHkTKLKsILEILSk X X -AURKB AurB Q96GD4 human AurB 9212 Q96GD4 AURKB human T16 15497293 PWPyGRQtAPsGLST X -AURKB AurB Q96GD4 human RPL21 6144 P46778 RPL21 human S104 14579432 kHSKsRDsFLkRVKE X -AURKB AurB Q96GD4 human Nlp 22981 Q9Y2I6 NINL human S448 15668107 QGYRERLsLLRSEVE X X -AURKB AurB Q96GD4 human HEC1 10403 O14777 NDC80 human S44 474539 kPtFGkLsINkPtsE X X -AURKB AurB Q96GD4 human H3 8350 P68431 H3C1 human S10 455676 tkQtArkstGGkAPr Histone X X 9701; 9711; 9606; 3465; 3642; 3377; 3475; 3458; 5764; 47398; 8481; 8552; 53348; 29237; 66065; 43185; 64522; 52725 -AURKB AurB Q96GD4 human H3 360198 P68433 H3c1 mouse S10 455676 tkQTARkstGGkAPr Histone X X 9701; 9711; 9606; 3465; 3642; 3377; 3475; 3458; 5764; 47398; 8481; 8552; 53348; 29237; 66065; 43185; 64522; 52725 -AURKB AurB Q96GD4 human RPRD1B 70470 Q9CSU0 Rprd1b mouse S145 10404515 kAAEEKKsLKRTFQQ X X -AURKB AurB Q96GD4 human ZWINT 11130 O95229 ZWINT human T251 20765002 TRPQEQstGDTMGRD Zwint X X -AURKB AurB Q96GD4 human SH2D4A 63898 Q9H788 SH2D4A human S261 7322753 REDYKRLsLGAQKGR X -AURKB AurB Q96GD4 human CASC5 57082 Q8NG31 KNL1 human S24 3829218 RPVRRRHssILkPPR X X -AURKB AurB Q96GD4 human Haspin 83903 Q8TF76 HASPIN human S4 1697837100 ____MAAsLPGPGsR X -AURKB AurB Q96GD4 human KIF2C 380006 Q91636 kif2c frog S110 2132101 KEVAAKNsLLSESGA X -AURKB AurB Q96GD4 human KIF4A 24137 O95239 KIF4A human S801 459849 KLRRRtFsLTEVRGQ X -AURKB AurB Q96GD4 human CASP2 12366 P29594 Casp2 mouse S384 1869992407 MRNTKRGsWYIEALT Peptidase_C14 X -AURKB AurB Q96GD4 human H2B1N 8341 Q99877 H2BC15 human Y83 11173388 EAsrLAHyNkrstIt Histone X -AURKB AurB Q96GD4 human H2B1M 8342 Q99879 H2BC14 human S78 50780223 ErIAGEAsrLAHyNk Histone X -AURKB AurB Q96GD4 human SEPT1 1731 Q8WYJ6 SEPTIN1 human S320 457108 RSKLSRQsAtEIPLP X -AURKB AurB Q96GD4 human KIF2C 11004 Q99661 KIF2C human S115 2132104 RsRstRMstVSELRI X -AURKB AurB Q96GD4 human RPS10 6204 P46783 RPS10 human T118 25752435 GERPARLtrGEADRD X -AURKB AurB Q96GD4 human H3F3A 3020 P84243 H3-3A human S10 18545301 tkQTARkstGGkAPR Histone X X 9706; 3458 -AURKB AurB Q96GD4 human HMGN2 3151 P05204 HMGN2 human S29 2574920 QRRsARLsAkPAPPk HMG14_17 X X -AURKB AurB Q96GD4 human DDX52 11056 Q9Y2R4 DDX52 human S22 10155029 kFDTRRFsADAArFQ X -AURKB AurB Q96GD4 human IkB-alpha 4792 P25963 NFKBIA human S262 1873119302 QLTWGRPsTRIQQQL X -AURKB AurB Q96GD4 human HIST1H2BJ 8970 P06899 H2BC11 human Y83 21691330 EAsrLAHyNkrstIT Histone X -AURKB AurB Q96GD4 human HEC1 10403 O14777 NDC80 human S5 474510 ___MKRSsVsSGGAG X -AURKB AurB Q96GD4 human HIST2H2BD 337874 Q6DRA6 H2BC19P human Y83 34433758 EAsrLAHyNkRSTIT Histone X -AURKB AurB Q96GD4 human ARHGAP21 57584 Q5T5U3 ARHGAP21 human S131 27777421 IIKVNGEsVIGKTYS PDZ_6 X -AURKB AurB Q96GD4 human AML2 864 Q13761 RUNX3 human T173 55571501 YHRAIkVtVDGPREP Runt X -AURKB AurB Q96GD4 human HP1 alpha 23468 P45973 CBX5 human S92 455944 SESNKRksNFsNsAD X X -AURKB AurB Q96GD4 human H2B1H 8345 Q93079 H2BC9 human S78 50780205 ErIAGEAsrLAHyNk Histone X -AURKB AurB Q96GD4 human H2B2F 440689 Q5QNW6 H2BC18 human S78 50780244 ErIAGEAsrLAHyNk Histone X -AURKB AurB Q96GD4 human HSP90B 3326 P08238 HSP90AB1 human S452 2565363 stNRRRLsELLRyHt HSP90 X -AURKB AurB Q96GD4 human HEC1 10403 O14777 NDC80 human S55 459763 PtsERkVsLFGkRts Ndc80_HEC X X -AURKB AurB Q96GD4 human H3F3A 3020 P84243 H3-3A human S28 18545302 ATkAARksAPsTGGV Histone X X -AURKB AurB Q96GD4 human CDT1 81620 Q9H211 CDT1 human T102 31889833 GQKIKKStPAAGQPP X -AURKB AurB Q96GD4 human p53 7157 P04637 TP53 human S183 18675301 CPHHERCsDsDGLAP P53 X X -AURKB AurB Q96GD4 human NAGK 55577 Q9UJ70 NAGK human S76 3245045 RsLGLsLsGGDQEDA BcrAD_BadFG X -AURKB AurB Q96GD4 human PLEKHG6 55200 Q3KR16 PLEKHG6 human T620 31834904 LRRDPRLtFSTLELR X -AURKB AurB Q96GD4 human LMO7 4008 Q8WWI1 LMO7 human S300 4687515 DMsyRRIsAVEPkTA DUF4757 X -AURKB AurB Q96GD4 human HIST1H2BJ 8970 P06899 H2BC11 human S78 50780565 ErIAGEAsrLAHyNk Histone X -AURKB AurB Q96GD4 human H3 8350 P68431 H3C1 human S28 455677 ATkAArksAPATGGV Histone X X 9713 -AURKB AurB Q96GD4 human LMO7 4008 Q8WWI1 LMO7 human S751 4687531 kWKDRRksYtsDLQK DUF4757 X -AURKB AurB Q96GD4 human NSBP1 79366 P82970 HMGN5 human S20 456122 RQEPKRRsARLsAML HMG14_17 X -AURKB AurB Q96GD4 human KIBRA 23286 Q8IX03 WWC1 human S539 20751200 tsLsPRSsLSsPSPP X X -AURKB AurB Q96GD4 human PLEKHG6 55200 Q3KR16 PLEKHG6 human S645 27458320 PQAPQRRsAPELPEG X -AURKB AurB Q96GD4 human GFAP 2670 P14136 GFAP human S13 449619 ItsAArrsyVSsGEM Filament_head X X -AURKB AurB Q96GD4 human H2B1N 8341 Q99877 H2BC15 human S78 50780230 ErIAGEAsrLAHyNk Histone X -AURKB AurB Q96GD4 human Haspin 83903 Q8TF76 HASPIN human S143 3207474 PPFPsRDsGRLsPDL X X -AURKB AurB Q96GD4 human RPL8 6132 P62917 RPL8 human S130 15423003 RGKLARAsGNyATVI Ribosomal_L2_C X -AURKB AurB Q96GD4 human KIF2C 11004 Q99661 KIF2C human S109 2132103 APkEsLRsRstRMst X -AURKB AurB Q96GD4 human HIST2H2BC 337873 Q6DN03 H2BC20P human Y83 34433756 EAsrLAHyNkRSTIT Histone X -AURKB AurB Q96GD4 human MIS18A 54069 Q9NYP9 MIS18A human S36 18012204 sLLGkrLsEDssRHQ X X -AURKB AurB Q96GD4 human CASC5 57082 Q8NG31 KNL1 human S60 459643 KKNSRRVsFADTIKV X X -AURKB AurB Q96GD4 human Survivin 332 O15392 BIRC5 human T34 447705 FLEGCACtPERMAEA BIR X 8888 -AURKB AurB Q96GD4 human SSU72 29101 Q9NP77 SSU72 human S3 10940613 _____MPssPLRVAV X -AURKB AurB Q96GD4 human p53 7157 P04637 TP53 human S269 17677100 GNLLGRNsFEVRVCA P53 X X -AURKB AurB Q96GD4 human KIF2C 11004 Q99661 KIF2C human S111 25159900 kEsLRsRstRMstVS X -AURKB AurB Q96GD4 human Diaphanous-2 iso4 1730 Q17R91 DIAPH2 human T882 18707507 KSADQKTtLLHFIAD FH2 X -AURKB AurB Q96GD4 human CDT1 81620 Q9H211 CDT1 human T358 1239966007 PPATEkLtTAQEVLA X -AURKB AurB Q96GD4 human SSU72 29101 Q9NP77 SSU72 human S19 29614601 CSSNQNRsMEAHNIL Ssu72 X X -AURKB AurB Q96GD4 human Borealin 55143 Q53HL2 CDCA8 human S154 482835 PSKKRtQsIQGKGKG X -AURKB AurB Q96GD4 human H2B 3018 P33778 H2BC3 human S78 50780176 ErIAGEAsrLAHyNk Histone X -AURKB AurB Q96GD4 human H2B1C 8347 P62807 H2BC4 human Y83 11173364 EAsrLAHyNkrstIt Histone X -AURKB AurB Q96GD4 human PLEKHG6 55200 Q3KR16 PLEKHG6 human T540 31834906 QDRESPStRPstPsL X -AURKB AurB Q96GD4 human SAS10 57050 Q9NQZ2 UTP3 human S462 12668129 RKEEQRYsGELsGIR Sas10 X -AURKB AurB Q96GD4 human CDCA5 113130 Q96FF9 CDCA5 human S139 20727378 DARDLEMsKKVRRsy Sororin X X -AURKB AurB Q96GD4 human IkB-alpha 4792 P25963 NFKBIA human S32 448203 LLDDRHDsGLDsMkD X 5210; 2859; 9246; 5209 -AURKB AurB Q96GD4 human KIF2C 380006 Q91636 kif2c frog S196 2132102 NNQGRRKsNIVKEME X X -AURKB AurB Q96GD4 human CDT1 81620 Q9H211 CDT1 human S143 1239966006 RVRALkAsAQDAGES X -AURKB AurB Q96GD4 human ZWINT 11130 O95229 ZWINT human S250 20765004 PTRPQEQstGDTMGR Zwint X X -AURKB AurB Q96GD4 human SSH3 54961 Q8TE77 SSH3 human S37 467353 SRLQRRQsFAVLRGA X 13873 -AURKB AurB Q96GD4 human H3 291159 Q6LED0 Hist1h2ail1 rat S10 455676 tkQTARkstGGkAPR Histone X 9701; 9711; 9606; 3465; 3642; 3377; 3475; 3458; 5764; 47398; 8481; 8552; 53348; 29237; 66065; 43185; 64522; 52725 -AURKB AurB Q96GD4 human AHNAK 79026 Q09666 AHNAK human T158 2565491 ItVtRRVtAytVDVT X -AURKB AurB Q96GD4 human CSIG 26156 O76021 RSL1D1 human T312 27777405 KRQQARktAsVLskD X -AURKB AurB Q96GD4 human RBMX 27316 P38159 RBMX human S326 3190081 GyGGsRDsysssRsD X -AURKB AurB Q96GD4 human INCENP 3619 Q9NQS7 INCENP human T494 27777401 kVVRPLRtFLHtVQR X -AURKB AurB Q96GD4 human CDCA5 113130 Q96FF9 CDCA5 human S33 472118 LRRsQRKsGsELPsI X X -AURKB AurB Q96GD4 human RBM3 5935 P98179 RBM3 human S147 3193835 QGGyDrysGGNyRDN X -AURKB AurB Q96GD4 human INCENP 3619 Q9NQS7 INCENP human S894 450468 RYHKRtssAVWNsPP X X -AURKB AurB Q96GD4 human 53BP1 7158 Q12888 TP53BP1 human S1342 3194873 GPLrGktsGtEPADF X X -AURKB AurB Q96GD4 human RPRD1B 58490 Q9NQG5 RPRD1B human S145 10404515 KATEEKKsLKRTFQQ X X -AURKB AurB Q96GD4 human ZFYVE19 84936 Q96K21 ZFYVE19 human S22 34488101 yAGCRRAsGFPALGR X -AURKB AurB Q96GD4 human DDX3 1654 O00571 DDX3X human S594 3174419 rSKssrFsGGFGArD X -AURKB AurB Q96GD4 human INCENP 3619 Q9NQS7 INCENP human S899 459782 tssAVWNsPPLQGAR X -AURKB AurB Q96GD4 human KIF2C 11004 Q99661 KIF2C human S192 2132102 VNsVRRKsCLVkEVE X -AURKB AurB Q96GD4 human H2BFH 8348 P23527 H2BC17 human Y83 11173345 EAsrLAHyNkrstIt Histone X -AURKB AurB Q96GD4 human PLEKHG6 55200 Q3KR16 PLEKHG6 human S546 31834907 StRPstPsLEGSQSS X -AURKB AurB Q96GD4 human hnRNP U 3192 Q00839 HNRNPU human S14 18010531 NVkKLkVsELkEELk SAP X -AURKB AurB Q96GD4 human GFAP 2670 P14136 GFAP human T7 449617 _MERRRItsAArrsy Filament_head X X -AURKB AurB Q96GD4 human AurB 9212 Q96GD4 AURKB human S7 459674 _MAQkENsyPWPyGR X -AURKB AurB Q96GD4 human Diaphanous-2 iso4 1730 Q17R91 DIAPH2 human T66 11147321 ITSFRKStVKKEKPL X -AURKB AurB Q96GD4 human RPA1 6117 P27694 RPA1 human S384 3189442 AIkGARVsDFGGRSL REPA_OB_2 X X -AURKB AurB Q96GD4 human p53 7157 P04637 TP53 human T284 18675300 CPGRDRRtEEENLrk P53 X X -AURKB AurB Q96GD4 human AurB 9212 Q96GD4 AURKB human T232 450325 APsLRRktMCGtLDy Pkinase X X 2914; 13464; 8525 -AURKB AurB Q96GD4 human HMGN2 3151 P05204 HMGN2 human S25 3146800 kDEPQRRsARLsAkP HMG14_17 X X -AURKB AurB Q96GD4 human smMLCK 396445 P11799 MYLK chicken S149 17555039 PPVEHRPsIWGESPP X -AURKB AurB Q96GD4 human MRLC2 103910 O14950 MYL12B human S20 448595 KRPQRAtsNVFAMFD X -AURKB AurB Q96GD4 human YY1 7528 P25490 YY1 human S184 476106 GKKsGKksyLsGGAG X X -AURKB AurB Q96GD4 human PAR3-alpha 56288 Q8TEW0 PARD3 human S962 11279402 SSRsGREsVSTAsDQ X X -AURKB AurB Q96GD4 human INCENP 3619 Q9NQS7 INCENP human S518 27777402 APRsVMKsFIKRNtP X -AURKB AurB Q96GD4 human PLK1 5347 P53350 PLK1 human T210 448139 YDGERKktLCGtPNy Pkinase X 4354; 5472; 9062 -AURKB AurB Q96GD4 human RDBP 7936 P18615 NELFE human S131 3181196 SRRPQRksLyEsFVS X -AURKB AurB Q96GD4 human CDCA2 157313 Q69YH5 CDCA2 human S977 10424830 EPGKRRKsFCIsTLA X X -AURKB AurB Q96GD4 human KIF23 iso2 9493 Q02241-2 KIF23 human S708 2902205 IRLRHRRsRsAGDRW MKLP1_Arf_bdg X -AURKB AurB Q96GD4 human CCDC86 79080 Q9H6F5 CCDC86 human S255 3965729 DRsKKRFsQMLQDkP Cgr1 X -AURKB AurB Q96GD4 human Borealin 55143 Q53HL2 CDCA8 human S165 475063 KGKGKRssRANtVtP Borealin X -AURKB AurB Q96GD4 human H2B2E 8349 Q16778 H2BC21 human Y83 11173368 EAsrLAHyNkrstIt Histone X -AURKB AurB Q96GD4 human Vimentin 7431 P08670 VIM human S73 449025 sAVrLrssVPGVRLL Filament_head X X -AURKB AurB Q96GD4 human hnRNP U 3192 Q00839 HNRNPU human S26 476219 ELkKRRLsDkGLkAE SAP X -AURKB AurB Q96GD4 human MgcRacGAP 29127 Q9H0H5 RACGAP1 human T249 478691 WTRSRRktGtLQPWN X -AURKB AurB Q96GD4 human NuMA-1 4926 Q14980 NUMA1 human S2047 4748253 kQADRRQsMAFsILN X -AURKB AurB Q96GD4 human H2B2E 8349 Q16778 H2BC21 human S78 50780236 ErIAGEAsrLAHyNk Histone X -AURKB AurB Q96GD4 human MYH10 4628 P35580 MYH10 human T1847 1874404500 ANKLVRRtEKKLKEI Myosin_tail_1 X X -AURKB AurB Q96GD4 human Nlp 22981 Q9Y2I6 NINL human S185 15668109 WDSEDFGsPQKSCsP X X -AURKB AurB Q96GD4 human CDCA5 113130 Q96FF9 CDCA5 human S83 3208977 PRRsPRIsFFLEKEN X X -AURKB AurB Q96GD4 human CDCA2 157313 Q69YH5 CDCA2 human S893 28698800 sETKVRRsTRLQKDL X X -AURKB AurB Q96GD4 human H3 360198 P68433 H3c1 mouse S28 455677 ATkAArksAPATGGV Histone X 9713 -AURKB AurB Q96GD4 human INCENP 3619 Q9NQS7 INCENP human T892 450466 KPRYHKRtssAVWNs X -AURKB AurB Q96GD4 human Oct4 18999 P20263 Pou5f1 mouse T343 291887109 AFPSVPVtALGsPMH X -AURKB AurB Q96GD4 human INCENP 3619 Q9NQS7 INCENP human T59 458332 EPELMPKtPSQKNRR X -AURKB AurB Q96GD4 human CHMP4C 92421 Q96CF2 CHMP4C human S215 1221009 RRsRAAssQRAEEED X X -AURKB AurB Q96GD4 human H2B1D 3017 P58876 H2BC5 human S78 50780196 ErIAGEAsrLAHyNk Histone X -AURKB AurB Q96GD4 human H2BFH 8348 P23527 H2BC17 human S78 50780248 ErIAGEAsrLAHyNk Histone X -AURKB AurB Q96GD4 human H2B1K 85236 O60814 H2BC12 human Y83 11173341 EAsrLAHyNkrstIt Histone X -AURKB AurB Q96GD4 human IkB-alpha 4792 P25963 NFKBIA human S63 1873119300 PQEVPRGsEPWkQQL X -AURKB AurB Q96GD4 human CDCA5 113130 Q96FF9 CDCA5 human T159 483401 LGsAStstPGRRsCF Sororin X X -AURKB AurB Q96GD4 human PLEKHG6 55200 Q3KR16 PLEKHG6 human S697 31834903 LRGQLPSsPTHADSA X -AURKB AurB Q96GD4 human CKAP2 26586 Q8WWK9 CKAP2 human T39 27446366 EHLLRRktLFAYKQE X -AURKB AurB Q96GD4 human HIST2H2BD 337874 Q6DRA6 H2BC19P human S78 50780571 ERIAGEAsrLAHyNk Histone X -AURKB AurB Q96GD4 human NSBP1 79366 P82970 HMGN5 human S24 456123 KRRsARLsAMLVPVt HMG14_17 X -AURKB AurB Q96GD4 human RBM14 10432 Q96PK6 RBM14 human S618 468597 LsDyrRLsEsQLsFR X -AURKB AurB Q96GD4 human MISP 126353 Q8IVT2 MISP human S348 27445089 RRERGRPsLyVQRDI AKAP2_C X -AURKB AurB Q96GD4 human SEPT1 1731 Q8WYJ6 SEPTIN1 human S312 457107 PGARDRAsRSKLSRQ X -AURKB AurB Q96GD4 human EB3 22924 Q9UPY8 MAPRE3 human S176 4740060 MQTSGRLsNVAPPCI X X -AURKB AurB Q96GD4 human CDCA5 113130 Q96FF9 CDCA5 human T151 28750703 RsysRLEtLGsASts Sororin X X -AURKB AurB Q96GD4 human Diaphanous-2 iso4 1730 Q17R91 DIAPH2 human S196 18707506 CLESLRVsLTSNPVS Drf_GBD X X -AURKB AurB Q96GD4 human CDCA5 113130 Q96FF9 CDCA5 human S164 9316471 tstPGRRsCFGFEGL Sororin X X -AURKB AurB Q96GD4 human H2B1K 85236 O60814 H2BC12 human S78 50780211 ErIAGEAsrLAHyNk Histone X -AURKB AurB Q96GD4 human INCENP 16319 Q9WU62 Incenp mouse S862 450468 RYHKRtssAVWNsPP X -AURKB AurB Q96GD4 human ARHGAP23 57636 Q9P227 ARHGAP23 human S127 27777422 LVkVNGEsVIGKTYS PDZ_6 X -AURKB AurB Q96GD4 human MCL1 4170 Q07820 MCL1 human T301 1868532700 ITDVLVRtkRDWLVk Bcl-2 X -AURKB AurB Q96GD4 human NuMA-1 4926 Q14980 NUMA1 human S1969 3196643 QEtLRRAsMQPIQIA X -AURKB AurB Q96GD4 human PTRF 284119 Q6NZI2 CAVIN1 human S300 465873 SRDkLRksFtPDHVV PTRF_SDPR X -AURKB AurB Q96GD4 human SPT16 11198 Q9Y5B9 SUPT16H human T494 7997652 EEAkRRLtEQkGEQQ X -AURKB AurB Q96GD4 human GBF1 8729 Q92538 GBF1 human S174 2565467 ICFEMRLsELLRKSA DCB X -AURKB AurB Q96GD4 human H2B 3018 P33778 H2BC3 human Y83 11173348 EAsrLAHyNkrstIt Histone X -AURKB AurB Q96GD4 human CDCA5 113130 Q96FF9 CDCA5 human T115 469416 VPAtPtStPVPNPEA Sororin X X -AURKB AurB Q96GD4 human CDCA2 157313 Q69YH5 CDCA2 human S981 26418520 RRKsFCIsTLANTKA X X -AURKB AurB Q96GD4 human Survivin 332 O15392 BIRC5 human T117 450947 kNkIAkEtNNkkkEF X X -AURKB AurB Q96GD4 human desmin 1674 P17661 DES human S12 449612 ysSSQRVssYRRtFG Filament_head X X -AURKB AurB Q96GD4 human CDT1 81620 Q9H211 CDT1 human T7 1239966005 _MEQRRVtDFFARRR X -AURKB AurB Q96GD4 human p53 7157 P04637 TP53 human S215 454242 DrNtFrHsVVVPyEP P53 X X -AURKB AurB Q96GD4 human INCENP 3619 Q9NQS7 INCENP human S893 450467 PRYHKRtssAVWNsP X X -AURKB AurB Q96GD4 human HEC1 10403 O14777 NDC80 human S69 474513 sGHGsRNsQLGIFss Ndc80_HEC X -AURKB AurB Q96GD4 human PLEKHG6 55200 Q3KR16 PLEKHG6 human S543 31834905 ESPStRPstPsLEGS X -AURKB AurB Q96GD4 human PRRC2C 23215 Q9Y520 PRRC2C human S1013 27777419 NDRPVRRsGPIKKPV X -AURKB AurB Q96GD4 human NPM1 18148 Q61937 Npm1 mouse S125 459897 AVEEDAEsEDEDEED X -AURKB AurB Q96GD4 human DSN1 79980 Q9H410 DSN1 human S100 480153 RQsWRRAsMKETNRR MIS13 X X -AURKB AurB Q96GD4 human NUDC 10726 Q9Y266 NUDC human T40 11164887 FSFLRRktDFFIGGE Nudc_N X -AURKB AurB Q96GD4 human CHMP4C 92421 Q96CF2 CHMP4C human S210 25123900 MSSTARRsRAAssQR X X -AURKB AurB Q96GD4 human NUSAP1 51203 Q9BXS6 NUSAP1 human S240 469451 VPPRGRLsVAstPIs NUSAP X -AURKB AurB Q96GD4 human RBM14 10432 Q96PK6 RBM14 human S649 3209652 HsDyArysGsyNDyL X -AURKB AurB Q96GD4 human HSP90B 3326 P08238 HSP90AB1 human S255 449266 PKIEDVGsDEEDDsG HSP90 X -AURKB AurB Q96GD4 human Haspin 83903 Q8TF76 HASPIN human S108 7990677 WKLRARPsLtVtPRR X X -AURKB AurB Q96GD4 human Borealin 55143 Q53HL2 CDCA8 human S275 482836 RLAQICssIRtHK__ Borealin X -AURKB AurB Q96GD4 human KI-67 4288 P46013 MKI67 human S374 459806 ytTGRREsVNLGkSE X -AURKB AurB Q96GD4 human Borealin 55143 Q53HL2 CDCA8 human S219 460351 YNIsGNGsPLADskE Borealin X -AURKB AurB Q96GD4 human p53 7157 P04637 TP53 human T211 25535400 EYLDDrNtFrHsVVV P53 X X -AURKB AurB Q96GD4 human CENPA 1058 P49450 CENPA human S7 448601 _MGPRRRsRKPEAPR Histone X 2187 -AURKB AurB Q96GD4 human RASSF1 iso2 11186 Q9NS23-2 RASSF1 human S203 484000 TsVRRRtsFYLPKDA RA X X -AURKB AurB Q96GD4 human DDA1 79016 Q9BW61 DDA1 human S33 1211350 kAsNRRPsVyLPTRE DDA1 X -AURKB AurB Q96GD4 human KIF23 9493 Q02241 KIF23 human S911 459840 NGsRKRRsstVAPAQ X -AURKB AurB Q96GD4 human SSU72 29101 Q9NP77 SSU72 human S4 10940616 ____MPssPLRVAVV X -AURKB AurB Q96GD4 human KIF2C 380006 Q91636 kif2c frog T95 451107 SQNHKRKtISKIPAP X X -AURKB AurB Q96GD4 human MPHOSPH10 10199 O00566 MPHOSPH10 human T332 14576278 KESLKRVtFALPDDA Mpp10 X -AURKB AurB Q96GD4 human SEPT1 1731 Q8WYJ6 SEPTIN1 human S253 457106 PVRGRRysWGtVEVE Septin X -AURKB AurB Q96GD4 human KI-67 4288 P46013 MKI67 human S538 3148110 EAPTKRksLVMHtPP PP1_bind X -AURKB AurB Q96GD4 human PKM 5315 P14618 PKM human T45 476071 PPItARNtGIICtIG PK X X -AURKB AurB Q96GD4 human CDCA5 113130 Q96FF9 CDCA5 human S79 470691 AVQsPRRsPRIsFFL X X -AURKB AurB Q96GD4 human CHMP4C 92421 Q96CF2 CHMP4C human S214 1247825 ARRsRAAssQRAEEE X X -AURKB AurB Q96GD4 human USP13 8975 Q92995 USP13 human S114 3849419 ALPkRRNsKIFLDLD X X -AURKB AurB Q96GD4 human DDX3Y 8653 O15523 DDX3Y human S592 4271209 RSKSNrFsGGFGArD X -AURKB AurB Q96GD4 human HDAC5 10014 Q9UQL6 HDAC5 human S278 4788482 QKVAERRssPLLRRK X X -AURKB AurB Q96GD4 human H2B2F 440689 Q5QNW6 H2BC18 human Y83 11173373 EAsrLAHyNkrstIt Histone X -AURKB AurB Q96GD4 human Plectin-1 5339 Q15149 PLEC human T2886 480098 PVRNRRLtVNEAVKE Plectin X -AURKB AurB Q96GD4 human INCENP 16319 Q9WU62 Incenp mouse S861 450467 TRYHKRtssAVWNsP X -AURKB AurB Q96GD4 human RBMXL1 494115 Q96E39 RBMXL1 human S326 11537510 GyGGsRDsysSSRsD X -RPS6KA2 RSK3 Q15349 human BUD13 84811 Q9BRD0 BUD13 human T159 470734 PRRARHDtPDPsPLR X X -RPS6KA2 RSK3 Q15349 human RSK3 6196 Q15349 RPS6KA2 human S218 1883400 DHDKRAysFCGtIEY Pkinase X -RPS6KA2 RSK3 Q15349 human BUD13 84811 Q9BRD0 BUD13 human S235 1221273 PRRARHGssDIssPR X X -RPS6KA2 RSK3 Q15349 human RSK3 6196 Q15349 RPS6KA2 human T570 478057 AGNGLLMtPCytANF Pkinase X -RPS6KA2 RSK3 Q15349 human CREB 1385 P16220 CREB1 human S119 448228 EILsRRPsyRkILND pKID X 9187; 9196; 9198; 4095; 14228; 14001; 39561; 80120; 44864; 54960; 95995 -RPS6KA2 RSK3 Q15349 human ataxin-1 6310 P54253 ATXN1 human S775 449110 AtRKRRWsAPESRKL X X -Fam20c FAM20C Q5MJS3 mouse FGF23 8074 Q9GZV9 FGF23 human S180 33365504 IPRRHtRsAEDDSER X -Fam20c FAM20C Q5MJS3 mouse HRC 3270 P23327 HRC human S96 34499322 EKEDEDVsKEyGHLL X -Fam20c FAM20C Q5MJS3 mouse FGF23 8074 Q9GZV9 FGF23 human S207 36400703 TPAPASCsQELPsAE X -Fam20c FAM20C Q5MJS3 mouse FGF23 64654 Q9EPC2 Fgf23 mouse S212 36400702 SCSRELPsAEEGGPA X -Fam20c FAM20C Q5MJS3 mouse FGF23 8074 Q9GZV9 FGF23 human S212 36400702 SCsQELPsAEDNSPM X -Mylk2 skMLCK Q8VCR8 mouse MYL7 17898 Q9QVP4 Myl7 mouse S23 465733 KQAQRGssNVFsMFE X -Mylk2 skMLCK Q8VCR8 mouse MYL7 17898 Q9QVP4 Myl7 mouse S22 465732 TKQAQRGssNVFsMF X -BLK BLK P51451 human BLK 12143 P16277 Blk mouse Y383 447715 ARIIDSEyTAQEGAK PK_Tyr_Ser-Thr X 70926; 78740; 94361; 17320 -BLK BLK P51451 human FAM83A 84985 Q86UY5 FAM83A human Y138 463316 EKssAtVyFQtVKHN FAM83 X X -BLK BLK P51451 human FCGR2A 2212 P12318 FCGR2A human Y304 449552 tDDDKNIyLTLPPND X -BLK BLK P51451 human FCGR2B 2213 P31994 FCGR2B human Y292 448507 GAENTITysLLMHPD X -BLK BLK P51451 human FCGR2A 2212 P12318 FCGR2A human Y288 449553 yEtADGGyMtLNPRA X -BLK BLK P51451 human SOCS1 8651 O15524 SOCS1 human Y80 1868450203 LLDACGFyWGPLSVH SH2 X -BLK BLK P51451 human cGAS 115004 Q8N884 CGAS human Y215 1271626200 LLNTGSYyEHVKIsA Mab-21 X -BLK BLK P51451 human FCGR2C 9103 P31995 FCGR2C human Y310 449501 tDDDKNIyLTLPPND X -BLK BLK P51451 human DBNL 13169 Q62418 Dbnl mouse Y340 450090 QTEEEPTyEVPPEQD X -BLK BLK P51451 human DBNL 13169 Q62418 Dbnl mouse Y350 450091 PPEQDTLyEEPPLVQ X -Csnk1e CK1E Q9JJ76 rat DARPP-32 360616 Q6J4I0 Ppp1r1b rat S137 448046 EEDEEEDsQAEVLKG DARPP-32 X -Csnk1e CK1E Q9JJ76 rat DARPP-32 360616 Q6J4I0 Ppp1r1b rat T34 448047 MIRRRRPtPALLFRV DARPP-32 X 12438 -BRD4 BRD4 O60885 human POLR2A 20020 P08775 Polr2a mouse S1616 450204 TPQSPSYsPtsPSYS RNA_pol_Rpb1_R X 4735; 13499; 13546; 31262 -BRD4 BRD4 O60885 human POLR2A 5430 P24928 POLR2A human S1616 450204 TPQSPSysPtsPsYS RNA_pol_Rpb1_R X X 4735; 13499; 13546; 31262 -Rock2 ROCK2 P70336 mouse MRLC1 10398 P24844 MYL9 human T19 1863501 KKRPQRAtsNVFAMF X 3674; 95777 -Rock2 ROCK2 P70336 mouse Ezrin 22350 P26040 Ezr mouse T567 448104 QGRDKYKtLRQIRQG ERM_C X X 3141; 3726; 32600 -Rock2 ROCK2 P70336 mouse calponin 3 71994 Q9DAW9 Cnn3 mouse S293 4776192 QGtGTNGsEIsDsDy X -Rock2 ROCK2 P70336 mouse IRS1 16367 P35569 Irs1 mouse S635 447507 yMPMsPKsVsAPQQI X X 2388 -Rock2 ROCK2 P70336 mouse MRLC2 67938 Q3THE2 Myl12b mouse S20 448595 KRPQRAtsNVFAMFD X -Rock2 ROCK2 P70336 mouse Moesin 17698 P26041 Msn mouse T558 447706 LGRDKYKtLRQIRQG ERM_C X X 3141; 3726; 32600 -Rock2 ROCK2 P70336 mouse Radixin 19684 P26043 Rdx mouse T564 448374 AGRDKYKtLRQIRQG ERM_C X X 3141; 3726; 32600 -Rock2 ROCK2 P70336 mouse ADD1 11518 Q9QYC0 Add1 mouse S724 449829 KKKFRtPsFLKKSKK X -Rock2 ROCK2 P70336 mouse IRF4 16364 Q64287 Irf4 mouse S447 12265165 HRSLRHssIQE____ X -Rock2 ROCK2 P70336 mouse calponin 3 71994 Q9DAW9 Cnn3 mouse S296 4776198 GTNGsEIsDsDyQAE X -Rock2 ROCK2 P70336 mouse IRS1 16367 P35569 Irs1 mouse S632 447506 NGDyMPMsPKsVsAP X X 2388 -Rock2 ROCK2 P70336 mouse IRF4 16364 Q64287 Irf4 mouse S446 26335000 YHRSLRHssIQE___ X -Rock2 ROCK2 P70336 mouse Cofilin-1 1072 P23528 CFL1 human S3 448444 _____MAsGVAVsDG X 3313; 3311 -Mylk2 skMLCK P20689 rat skMLCK 117558 P20689 Mylk2 rat S168 2864200 PAFLHsPsCPAIISC X -MYLK smMLCK P11799 chicken MRLC1 296313 Q64122 Myl9 rat S20 1863500 KRPQSAtsNVFAMFD X 3674; 3671; 3675; 95777 -MYLK smMLCK P11799 chicken smMLCK 396445 P11799 MYLK chicken S1765 468781 GRKAsGssPTsPINA X -MYLK smMLCK P11799 chicken TNNI3 21954 P48787 Tnni3 mouse T144 451483 RGKFKRPtLRRVRIs Troponin X -MYLK smMLCK P11799 chicken MRLC3 10627 P19105 MYL12A human S19 7382102 KRPQRAtsNVFAMFD X -MYLK smMLCK P11799 chicken MRLC1 296313 Q64122 Myl9 rat T19 1863501 KKRPQSAtsNVFAMF X 3674; 95777 -MYLK smMLCK P11799 chicken smMLCK 396445 P11799 MYLK chicken T1797 2874403 PHVKPYFtKtILDME I-set X -MYLK smMLCK P11799 chicken smMLCK 396445 P11799 MYLK chicken S1749 466361 RAIGRLSsMAMISGM X -MYLK smMLCK P11799 chicken TNNI3 21954 P48787 Tnni3 mouse S45 450691 KKSKIsAsRKLQLkT X -MYLK smMLCK P11799 chicken smMLCK 396445 P11799 MYLK chicken S1757 2874409 MAMISGMsGRKAsGs X -MYLK smMLCK P11799 chicken smMLCK 396445 P11799 MYLK chicken T1799 2874402 VKPYFtKtILDMEVV I-set X -MYLK smMLCK P11799 chicken MRLC1 10398 P24844 MYL9 human S20 1863500 KRPQRAtsNVFAMFD X 3674; 3671; 3675; 95777 -MYLK smMLCK P11799 chicken MRLC1 98932 Q9CQ19 Myl9 mouse S20 1863500 KRPQRAtsNVFAMFD X 3674; 3671; 3675; 95777 -MYLK smMLCK P11799 chicken MRLC1 98932 Q9CQ19 Myl9 mouse T19 1863501 KKRPQRAtsNVFAMF X 3674; 95777 -MYLK smMLCK P11799 chicken smMLCK 396445 P11799 MYLK chicken T1737 2874410 ARRKWQKtGHAVRAI X -MYLK smMLCK P11799 chicken smMLCK 396445 P11799 MYLK chicken S1764 2874401 sGRKAsGssPTsPIN X -MYLK smMLCK P11799 chicken TNNI3 21954 P48787 Tnni3 mouse S43 450690 AkKKSKIsAsRKLQL X -MYLK smMLCK P11799 chicken MRLC3 10627 P19105 MYL12A human T18 7382101 KKRPQRAtsNVFAMF X -Bckdk BCKDK Q00972 rat BCKDH E1-alpha 25244 P11960 Bckdha rat S333 449636 TYRIGHHstsDDSSA E1_dh X X 40368 -Bckdk BCKDK Q00972 rat BCKDH E1-alpha 593 P12694 BCKDHA human S347 451657 DDssAyRsVDEVNyW E1_dh X -Bckdk BCKDK Q00972 rat BCKDK 29603 Q00972 Bckdk rat S52 2874404 ERSKTVTsFYNQSAI X -Bckdk BCKDK Q00972 rat BCKDH E1-alpha 25244 P11960 Bckdha rat S343 451657 DDSSAyRsVDEVNYW E1_dh X -Bckdk BCKDK Q00972 rat BCKDHB 594 P21953 BCKDHB human S318 3336900 DVDTICKsVIKTGRL Transketolase_C X -Bckdk BCKDK Q00972 rat BCKDH E1-alpha 593 P12694 BCKDHA human S337 449636 TYRIGHHstsDDssA E1_dh X 40368 -NEK2 NEK2 P51955 human NEK2 4751 P51955 NEK2 human S241 12574600 RRIPYRYsDELNEII Pkinase X -NEK2 NEK2 P51955 human Tara iso5 11078 Q9H2D6-5 TRIOBP human T221 33365503 RRKWFEAtDSRTPEV X -NEK2 NEK2 P51955 human CEP250 11190 Q9BV73 CEP250 human S2417 20831304 ETRRLDEsLtQsLTs X -NEK2 NEK2 P51955 human LIP8 116840 Q8N137 CNTROB human S41 27565613 VtsQLYAsLRLsRQA X -NEK2 NEK2 P51955 human NPM1 4869 P06748 NPM1 human S88 4169620 MsVQPtVsLGGFEIt Nucleoplasmin X -NEK2 NEK2 P51955 human SGO1 151648 Q5FBB7 SGO1 human S14 486241 LKKSFQDsLEDIkKR X X -NEK2 NEK2 P51955 human EEF2 1938 P13639 EEF2 human S595 27620701 NVLCLsksPNkHNRL X -NEK2 NEK2 P51955 human NEK2 4751 P51955 NEK2 human S397 1983725 skENIMRsENsEsQL X -NEK2 NEK2 P51955 human NEK2 4751 P51955 NEK2 human S428 12574605 QLRAQALsDIEkNYQ X -NEK2 NEK2 P51955 human DVL3 1857 Q92997 DVL3 human S643 34668102 sHHsLAssLRSHHTH Dsh_C X X -NEK2 NEK2 P51955 human FANCA 2175 O15360 FANCA human T351 11076033 REWsFARtHPLLTsL Fanconi_A_N X X -NEK2 NEK2 P51955 human LRRC45 201255 Q96CN5 LRRC45 human S661 28850300 VLAYVQAsPVRtLsP X X -NEK2 NEK2 P51955 human NEK2 4751 P51955 NEK2 human T170 4271902 ARILNHDtsFAktFV Pkinase X -NEK2 NEK2 P51955 human SGO1 151648 Q5FBB7 SGO1 human S507 486242 TDLCFLNsPIFKQKK X X -NEK2 NEK2 P51955 human GAS2L1 10634 Q99501 GAS2L1 human S352 1974202 HPRSRRysGDsDssA X X -NEK2 NEK2 P51955 human NEK2 4751 P51955 NEK2 human S171 12574604 RILNHDtsFAktFVG Pkinase X -NEK2 NEK2 P51955 human NEK2 4751 P51955 NEK2 human S402 478164 MRsENsEsQLtsksK X -NEK2 NEK2 P51955 human DVL3 1857 Q92997 DVL3 human S697 4729017 VPPELTAsrQsFRMA Dsh_C X X -NEK2 NEK2 P51955 human NEK2 4751 P51955 NEK2 human S356 12574602 ENLLkNYsLLkERkF X -NEK2 NEK2 P51955 human LIP8 116840 Q8N137 CNTROB human T35 27565612 NQVSSEVtsQLYAsL X -NEK2 NEK2 P51955 human CEP250 11190 Q9BV73 CEP250 human S2064 1869636100 REQLLEksLAQRVQE X -NEK2 NEK2 P51955 human PPP1CC 5501 P36873 PPP1CC human T307 3190033 EKKkPNAtRPVtPPR X -NEK2 NEK2 P51955 human PD-L1 29126 Q9NZQ7 CD274 human T194 1874101908 EEKLFNVtsTLRINT C2-set_2 X X -NEK2 NEK2 P51955 human DVL3 1857 Q92997 DVL3 human T15 34668103 YHLDGQEtPYLVKLP DIX X X -NEK2 NEK2 P51955 human TRF1 7013 P54274 TERF1 human S114 63083903 AIIHGLSsLTACQLR TRF X -NEK2 NEK2 P51955 human NEK2 4751 P51955 NEK2 human T175 12574603 HDtsFAktFVGtPYY Pkinase X -NEK2 NEK2 P51955 human NPM1 4869 P06748 NPM1 human S70 459898 EAMNyEGsPIkVtLA Nucleoplasmin X -NEK2 NEK2 P51955 human PD-L1 29126 Q9NZQ7 CD274 human T210 1874101910 TNEIFYCtFRRLDPE C2-set_2 X X -NEK2 NEK2 P51955 human YAP1 10413 P46937 YAP1 human T143 3190678 AVsPGtLtPtGVVsG X -NEK2 NEK2 P51955 human LIP8 116840 Q8N137 CNTROB human S36 27565611 QVSSEVtsQLYAsLR X -NEK2 NEK2 P51955 human NEK2 4751 P51955 NEK2 human T179 12574601 FAktFVGtPYYMsPE Pkinase X -NEK2 NEK2 P51955 human PPP1CC 5501 P36873 PPP1CC human T318 11379600 tPPRGMItkQAkK__ X -NEK2 NEK2 P51955 human HEC1 10403 O14777 NDC80 human S165 449867 LGYPFALsKSSMYTV Ndc80_HEC X X -NEK2 NEK2 P51955 human OLA1 29789 Q9NTK5 OLA1 human T124 1883583904 CDGIFHLtRAFEDDD X -NEK2 NEK2 P51955 human DVL3 1857 Q92997 DVL3 human S280 34668101 DGGIYIGsIMkGGAV PDZ X X -NEK2 NEK2 P51955 human CEP250 11190 Q9BV73 CEP250 human S2421 20831305 LDEsLtQsLTsPGPV X -NEK2 NEK2 P51955 human p53 7157 P04637 TP53 human S315 447530 LPNNtsssPQPkkkP X X 2528 -NEK2 NEK2 P51955 human LIP8 116840 Q8N137 CNTROB human S45 27565614 LYAsLRLsRQAEATA X -PIM1 Pim1 P11309 human LDH-A 3939 P00338 LDHA human S161 31882218 PkNrVIGsGCNLDsA X X -PIM1 Pim1 P11309 human UHRF1 iso2 29128 Q96T88-2 UHRF1 human S311 2902206 DNPMRRKsGPSCKHC X X -PIM1 Pim1 P11309 human CAPZA1 829 P52907 CAPZA1 human S126 1870026100 SWREsCDsALRAYVk F-actin_cap_A X X -PIM1 Pim1 P11309 human 4E-BP1 13685 Q60876 Eif4ebp1 mouse S64 447527 FLMECRNsPVAKtPP eIF_4EBP X 9451; 9456 -PIM1 Pim1 P11309 human p21Cip1 1026 P38936 CDKN1A human S146 447836 GRkRRQtsMTDFyHs X -PIM1 Pim1 P11309 human DRP1 10059 O00429 DNM1L human S637 483971 VPVARKLsAREQRDC X 4867; 6319 -PIM1 Pim1 P11309 human MARK3 iso3 4140 P27448-3 MARK3 human T95 3597305 DKtQLNPtsLQKLFR Pkinase X -PIM1 Pim1 P11309 human CBX8 57332 Q9HC52 CBX8 human S196 1874101936 PssPGDSsKKRGPKP X X -PIM1 Pim1 P11309 human NFAT2 4772 O95644 NFATC1 human S245 448861 PSTsPRAsVTEEsWL X -PIM1 Pim1 P11309 human AML2 864 Q13761 RUNX3 human T155 6097703 ksFtLtItVFTNPTQ Runt X -PIM1 Pim1 P11309 human NFAT2 4772 O95644 NFATC1 human S269 448862 PCNKRKYsLNGRQPP X -PIM1 Pim1 P11309 human 14-3-3 zeta 7534 P63104 YWHAZ human S64 10407031 ssWRVVssIEQkTEG 14-3-3 X X -PIM1 Pim1 P11309 human DEPDC5 9681 O75140 DEPDC5 human S1530 3845300 QQRRRRNstSSTNQN DEPDC5_CTD X -PIM1 Pim1 P11309 human p27Kip1 1027 P46527 CDKN1B human T157 448645 GIRkrPAtDDSSTQN X X -PIM1 Pim1 P11309 human NKX3-1 4824 Q99801 NKX3-1 human S186 7998431 TKRkQLssELGDLEK X -PIM1 Pim1 P11309 human MDM2 4193 Q00987 MDM2 human S186 448131 RQRkRHksDsIsLsF X X -PIM1 Pim1 P11309 human H3 8350 P68431 H3C1 human S10 455676 tkQtArkstGGkAPr Histone X X 9701; 9711; 9606; 3465; 3642; 3377; 3475; 3458; 5764; 47398; 8481; 8552; 53348; 29237; 66065; 43185; 64522; 52725 -PIM1 Pim1 P11309 human NFAT2 4772 O95644 NFATC1 human T154 1869090801 SSKRsPstATLsLPs X -PIM1 Pim1 P11309 human ABCG2 9429 Q9UNQ0 ABCG2 human T362 1818104 GEkKKKItVFKEISY X -PIM1 Pim1 P11309 human SKP2 6502 Q13309 SKP2 human T417 15165300 WGIkCRLtLQkPSCL X -PIM1 Pim1 P11309 human LKB1 6794 Q15831 STK11 human S334 448146 DTKDRWRsMtVVPYL X X 3055 -PIM1 Pim1 P11309 human NFAT2 4772 O95644 NFATC1 human S151 56629000 VLPSSKRsPstATLs X -PIM1 Pim1 P11309 human STAT5B 6777 P51692 STAT5B human S731 448751 TyMDQAPsPAVCPQA X -PIM1 Pim1 P11309 human S6 20104 P62754 Rps6 mouse S235 448092 IAKRRRLssLRAsts X 5006; 4856; 4857; 4858; 4851; 4803; 2211; 3945; 3985; 5316; 4854; 8520; 48319; 40643; 9865; 38573; 14733; 27036; 34411; 62016; 62788; 81736; 97935; 99457; 15448 -PIM1 Pim1 P11309 human AR 367 P10275 AR human T851 5204777 ACkRkNPtSCSRRFy Hormone_recep X X -PIM1 Pim1 P11309 human NKX3-1 4824 Q99801 NKX3-1 human S195 4913200 LGDLEKHssLPALKE X -PIM1 Pim1 P11309 human BAD 12015 Q61337 Bad mouse S112 447860 ETRsRHssyPAGtEE Bcl-2_BAD X X 9291; 5284; 9296; 5193; 11865; 94223 -PIM1 Pim1 P11309 human NKX3-1 4824 Q99801 NKX3-1 human S196 4825100 GDLEKHssLPALKEE X -PIM1 Pim1 P11309 human NFAT2 4772 O95644 NFATC1 human S153 1869090803 PSSKRsPstATLsLP X -PIM1 Pim1 P11309 human NFAT2 4772 O95644 NFATC1 human T339 1869090805 PVKsRkttLEQPPsV X -PIM1 Pim1 P11309 human Myc 4609 P01106 MYC human S308 10852562 GHskPPHsPLVLkrC Myc_N X -PIM1 Pim1 P11309 human AR 367 P10275 AR human S215 448577 SGRAREAsGAPtsSK Androgen_recep X X -PIM1 Pim1 P11309 human p21Cip1 1026 P38936 CDKN1A human T145 447837 QGRkRRQtsMTDFyH X X -PIM1 Pim1 P11309 human LDH-A 3939 P00338 LDHA human S319 24986816 EEARLkksADtLWGI Ldh_1_C X -PIM1 Pim1 P11309 human CXCR4 12767 P70658 Cxcr4 mouse S346 458320 GKRGGHssVsTESEs X 59028 -PIM1 Pim1 P11309 human HBP1 26959 O60381 HBP1 human S372 63253100 SAVYVLSsMARQRrA X X -PIM1 Pim1 P11309 human NFAT2 4772 O95644 NFATC1 human S335 1869090800 GDGVPVKsRkttLEQ X -PIM1 Pim1 P11309 human CAPZB iso1 832 P47756-1 CAPZB human S226 27445587 DMENkIRsTLNEIyF F_actin_cap_B X X -PIM1 Pim1 P11309 human NKX3-1 4824 Q99801 NKX3-1 human S185 4825101 KTKRkQLssELGDLE X -PIM1 Pim1 P11309 human SKP2 6502 Q13309 SKP2 human S64 457412 sNLGHPEsPPRkRLk X 14865 -PIM1 Pim1 P11309 human BAD 12015 Q61337 Bad mouse S155 447863 GRELRRMsDEFEGsF Bcl-2_BAD X X 9297 -PIM1 Pim1 P11309 human EIF4B 1975 P23588 EIF4B human S406 470374 RPRERHPsWRsEEtQ X 8151; 5399 -PIM1 Pim1 P11309 human SKP2 6502 Q13309 SKP2 human S72 480507 PPRkRLkskGsDkDF X -PIM1 Pim1 P11309 human Myc 17869 P01108 Myc mouse S344 2750300 AkRAKLDsGRVLKQI Myc_N X X -PIM1 Pim1 P11309 human ASK1 4217 Q99683 MAP3K5 human S83 447735 ATRGRGssVGGGSrR X X 3761 -PIM1 Pim1 P11309 human BAD 572 Q92934 BAD human S75 447860 EIRsRHssyPAGtED Bcl-2_BAD X 9291; 5284; 9296; 5193; 11865; 94223 -PIM1 Pim1 P11309 human AR 367 P10275 AR human S220 1875072200 EAsGAPtsSKDNyLG Androgen_recep X -PIM1 Pim1 P11309 human AML2 864 Q13761 RUNX3 human S149 6097701 GRSGRGksFtLtItV Runt X -PIM1 Pim1 P11309 human Oct4 5460 Q01860 POU5F1 human S288 22830416 RRQKGKRsssDyAQR X -PIM1 Pim1 P11309 human IRS1 3667 P35568 IRS1 human S1101 453434 GCRRRHssEtFsStP X X -PIM1 Pim1 P11309 human Abi-2 10152 Q9NYB9 ABI2 human S183 4710620 PPtQKPPsPPMsGKG X X -PIM1 Pim1 P11309 human MDM2 4193 Q00987 MDM2 human S166 448130 SsRRRAIsEtEENsD X X 3521 -PIM1 Pim1 P11309 human FOXO3A 2309 O43524 FOXO3 human T32 448602 QsRPRsCtWPLQRPE X 2599; 9464 -PIM1 Pim1 P11309 human CAPZB iso1 832 P47756-1 CAPZB human T186 14571038 tNKsGsGtMNLGGsL F_actin_cap_B X X -PIM1 Pim1 P11309 human eNOS 4846 P29474 NOS3 human S633 448637 WRRKRKEssNtDsAG Flavodoxin_1 X X -PIM1 Pim1 P11309 human IRS2 8660 Q9Y4H2 IRS2 human S1149 453435 GGRRRHssEtFSsTt X 2385 -PIM1 Pim1 P11309 human p27Kip1 1027 P46527 CDKN1B human T198 448781 PGLRRRQt_______ X X -PIM1 Pim1 P11309 human HIF1A 3091 Q16665 HIF1A human T455 31887953 LAMsPLPtAEtPkPL X X -PIM1 Pim1 P11309 human NFAT2 4772 O95644 NFATC1 human S256 1869090802 EsWLGARssRPAsPC X -PIM1 Pim1 P11309 human HBP1 26959 O60381 HBP1 human S380 3252925 MARQRrAsLsCGGPG X X -PIM1 Pim1 P11309 human Notch 1 18128 Q01705 Notch1 mouse S2152 3252805 GkkARkPsTkGLACG X X -PIM1 Pim1 P11309 human PSMD2 5708 Q13200 PSMD2 human S361 487471 ENNrFGGsGsQVDsA X X -PIM1 Pim1 P11309 human AML2 864 Q13761 RUNX3 human T151 6097702 SGRGksFtLtItVFT Runt X -PIM1 Pim1 P11309 human MARK3 iso3 4140 P27448-3 MARK3 human T90 3597303 AIKIIDKtQLNPtsL Pkinase X -PIM1 Pim1 P11309 human CAPZA1 829 P52907 CAPZA1 human S106 27445584 DHLRkEAsDPQPEEA F-actin_cap_A X X -PIM1 Pim1 P11309 human NFkB-p65 5970 Q04206 RELA human S276 447798 sMQLRRPsDRELsEP RHD_dimer X X -PIM1 Pim1 P11309 human NDRG1 10397 Q92597 NDRG1 human S330 452879 LMRsRtAsGssVtsL X 3506; 11899 -PIM1 Pim1 P11309 human NFAT2 4772 O95644 NFATC1 human S257 40512526 sWLGARssRPAsPCN X -PIM1 Pim1 P11309 human HIF2A 2034 Q99814 EPAS1 human S435 1874020200 GKAILPPsQPWATEL X -PIM1 Pim1 P11309 human NFAT2 4772 O95644 NFATC1 human T338 1869090804 VPVKsRkttLEQPPs X -PIM1 Pim1 P11309 human CAPZB iso1 832 P47756-1 CAPZB human S192 23090287 GtMNLGGsLtRQMEk F_actin_cap_B X X -PIM1 Pim1 P11309 human Oct4 5460 Q01860 POU5F1 human S289 22830418 RQKGKRsssDyAQRE X -PIM1 Pim1 P11309 human CXCR4 7852 P61073 CXCR4 human S339 458320 GkrGGHssVstEsEs X 59028 -PIM1 Pim1 P11309 human NKX3-1 4824 Q99801 NKX3-1 human T89 464287 AAPEEAEtLAEtEPE X -PIM1 Pim1 P11309 human MARK3 iso3 4140 P27448-3 MARK3 human S96 3597304 KtQLNPtsLQKLFRE Pkinase X -PIM1 Pim1 P11309 human AML2 864 Q13761 RUNX3 human T153 6097700 RGksFtLtItVFTNP Runt X -PIM1 Pim1 P11309 human BAD 12015 Q61337 Bad mouse S136 447862 PFRGRsRsAPPNLWA Bcl-2_BAD X X 9295; 5286; 4366 -PIM1 Pim1 P11309 human FOXO3A 2309 O43524 FOXO3 human S253 449108 APRRRAVsMDNSNkY X 9466; 13129 -PIM1 Pim1 P11309 human S6 20104 P62754 Rps6 mouse S236 448093 AKRRRLssLRAstsK X 5006; 4856; 4857; 4858; 4851; 4803; 2211; 3945; 3985; 5316; 4854; 8520; 48319; 40643; 9865; 38573; 14733; 27036; 34411; 62016; 62788; 81736; 97935; 99457; 15448 -PIM1 Pim1 P11309 human NFAT2 4772 O95644 NFATC1 human S278 41453273 NGRQPPYsPHHsPTP X -PIM1 Pim1 P11309 human FOXP3 50943 Q9BZS1 FOXP3 human S422 35517300 KkRsQRPsRCSNPTP X X -STK4 MST1 Q13043 human TNNI3 7137 P19429 TNNI3 human T129 6796400 ITEIADLtQkIFDLR Troponin X X -STK4 MST1 Q13043 human PRDX1 5052 Q06830 PRDX1 human T183 476233 GWkPGsDtIkPDVQk 1-cysPrx_C X -STK4 MST1 Q13043 human GR 2908 P04150 NR3C1 human S682 1872513508 VPkDGLksQELFDEI Hormone_recep X -STK4 MST1 Q13043 human GJA1 2697 P17302 GJA1 human S255 448852 HAtsGALsPAkDCGs X X -STK4 MST1 Q13043 human MST1 6789 Q13043 STK4 human T183 447925 DtMAkRNtVIGTPFW Pkinase X X 3681; 49332 -STK4 MST1 Q13043 human FOXO1A 2308 Q12778 FOXO1 human S212 4258803 SSAGWkNsIRHNLsL Forkhead X -STK4 MST1 Q13043 human Abl 25 P00519 ABL1 human T735 450291 DTEWRSVtLPRDLQS X 2864 -STK4 MST1 Q13043 human FOXO1A 2308 Q12778 FOXO1 human S218 4258805 NsIRHNLsLHSkFIR Forkhead X -STK4 MST1 Q13043 human GR 2908 P04150 NR3C1 human T562 1872513501 StWRIMTtLNMLGGR Hormone_recep X -STK4 MST1 Q13043 human MOB1A 55233 Q9H8S9 MOB1A human T35 3212769 LLkHAEAtLGsGNLR Mob1_phocein X X 8699 -STK4 MST1 Q13043 human Bcl-xL 12048 Q64373 Bcl2l1 mouse S14 33668512 ELVVDFLsYKLSQKG BH4 X X -STK4 MST1 Q13043 human LC3B 67443 Q9CQV6 Map1lc3b mouse T50 37045604 QLPVLDktkFLVPDH ATG8 X X -STK4 MST1 Q13043 human AMPKA1 5562 Q13131 PRKAA1 human T183 448786 sDGEFLRtsCGsPNy Pkinase X 2535; 2531; 4188; 5256; 50081; 74281 -STK4 MST1 Q13043 human H2B 3018 P33778 H2BC3 human S14 449904 APAPkkGskkAItkA Histone X X 6959 -STK4 MST1 Q13043 human NDR1 11329 Q15208 STK38 human T444 460659 DWVFINytyKRFEGL Pkinase_C X -STK4 MST1 Q13043 human LATS2 305922 NP_001100737 Lats2 rat T999 31843001 EHAFYEFtFRRFFDD Pkinase_C X 8654 -STK4 MST1 Q13043 human TNNI3 7137 P19429 TNNI3 human T143 451483 RGKFKRPtLRrVrIs Troponin X X -STK4 MST1 Q13043 human MST1 6789 Q13043 STK4 human T353 64227000 TMTDGANtMIEHDDt X -STK4 MST1 Q13043 human FOXO3A 2309 O43524 FOXO3 human S243 464652 INPDGGksGkAPRRR Forkhead X -STK4 MST1 Q13043 human FOXO3A 2309 O43524 FOXO3 human S209 464289 SSAGWkNsIRHNLsL Forkhead X X -STK4 MST1 Q13043 human GR 2908 P04150 NR3C1 human T668 1872513506 EEYLCMKtLLLLSSV Hormone_recep X -STK4 MST1 Q13043 human LATS1 9113 O95835 LATS1 human T1079 457595 EHAFyEFtFRRFFDD X 8654 -STK4 MST1 Q13043 human UNC5B 219699 Q8IZJ1 UNC5B human T428 1870414700 FHPVNFKtARPSNPQ X -STK4 MST1 Q13043 human beclin 1 8678 Q14457 BECN1 human T108 29606706 GEASDGGtMENLSRR BH3 X X -STK4 MST1 Q13043 human PRDX1 5052 Q06830 PRDX1 human T90 455554 CHLAWVNtPkkQGGL AhpC-TSA X -STK4 MST1 Q13043 human LATS1 308265 F1M2K4 Lats1 rat T1079 457595 EHAFYEFtFRRFFDD X 8654 -STK4 MST1 Q13043 human FOXO3A 2309 O43524 FOXO3 human S231 465447 QNEGTGKssWWIINP Forkhead X -STK4 MST1 Q13043 human IRF3 3661 Q14653 IRF3 human T75 55458201 RDkPDLPtWkRNFRs IRF X X -STK4 MST1 Q13043 human YAP1 22601 P46938 Yap1 mouse S112 448847 PQHVRAHssPAsLQL X 4911; 13008; 92367; 57706 -STK4 MST1 Q13043 human MST1 58231 Q9JI11 Stk4 mouse S327 447924 sEEDEMDsGtMVRAA X -STK4 MST1 Q13043 human FOXO1A 2308 Q12778 FOXO1 human S235 4258802 NEGTGKssWWMLNPE Forkhead X -STK4 MST1 Q13043 human GR 2908 P04150 NR3C1 human S746 1872513507 TFLDKTMsIEFPEML X -STK4 MST1 Q13043 human AurB 9212 Q96GD4 AURKB human T232 450325 APsLRRktMCGtLDy Pkinase X 2914; 13464; 8525 -STK4 MST1 Q13043 human FOXO1A 2308 Q12778 FOXO1 human S234 4258804 QNEGTGKssWWMLNP Forkhead X -STK4 MST1 Q13043 human FOXO3A 2309 O43524 FOXO3 human S232 465448 NEGTGKssWWIINPD Forkhead X -STK4 MST1 Q13043 human TNNI3 7137 P19429 TNNI3 human T31 6796401 sNyRAyAtEPHAKKK Troponin-I_N X X -STK4 MST1 Q13043 human LC3B 81631 Q9GZQ8 MAP1LC3B human T50 37045604 QLPVLDktkFLVPDH ATG8 X X -STK4 MST1 Q13043 human Nur77 3164 P22736 NR4A1 human T366 1881000304 AsPANLLtSLVRAHL X X -STK4 MST1 Q13043 human FOXO3A 2309 O43524 FOXO3 human S215 464651 NsIRHNLsLHSRFMR Forkhead X -STK4 MST1 Q13043 human MOB1B 92597 Q7L9L4 MOB1B human T35 3545001 LLkHAEAtLGsGNLR Mob1_phocein X 8699 -STK4 MST1 Q13043 human ITGA2 3673 P17301 ITGA2 human S1180 3181118 IDETtELss______ X -STK4 MST1 Q13043 human MST1 6789 Q13043 STK4 human T367 7445972 tLPSQLGtMVINAED X -STK4 MST1 Q13043 human QSK 23387 Q9Y2K2 SIK3 human T221 456036 TPGQLLKtWCGSPPY Pkinase X -STK4 MST1 Q13043 human PRDX1 5052 Q06830 PRDX1 human T18 17401748 PAPNFkAtAVMPDGQ AhpC-TSA X -STK4 MST1 Q13043 human H2AX 3014 P16104 H2AX human S139 448841 GkkAtQAsQEy____ X X 2577; 9719; 9720; 9718; 4309; 5763; 5438; 93629; 80312; 20304; 85410; 97148; 60566; 59141 -STK4 MST1 Q13043 human TNNI3 7137 P19429 TNNI3 human T51 6796402 sRKLQLKtLLLQIAK Troponin X X -STK4 MST1 Q13043 human MOB1B 92597 Q7L9L4 MOB1B human T12 3545000 FGsRssktFKPkkNI X 8843 -STK4 MST1 Q13043 human FOXO1A 84482 G3V7R4 Foxo1 rat S206 4258803 SSAGWKNsIRHNLSL Forkhead X X -STK4 MST1 Q13043 human IRF3 3661 Q14653 IRF3 human T253 55458200 PDPGMSLtDRGVMsY IRF-3 X X -STK4 MST1 Q13043 human L-plastin 18826 Q61233 Lcp1 mouse T89 3851696 KSTEVAKtFRKAINK X X -Ripk3 RIPK3 Q9QZL0 mouse MLKL 74568 Q9D2Y4 Mlkl mouse T349 8148779 TQNsIsRtAKSTKAE PK_Tyr_Ser-Thr X -Ripk3 RIPK3 Q9QZL0 mouse AMPKA1 105787 Q5EG47 Prkaa1 mouse T183 448786 sDGEFLRtsCGsPNY Pkinase X 2535; 2531; 4188; 5256; 50081; 74281 -Ripk3 RIPK3 Q9QZL0 mouse RIPK3 56532 Q9QZL0 Ripk3 mouse S232 23003800 AELVDKtsLIRETVC Pkinase X X 57220; 91702 -Ripk3 RIPK3 Q9QZL0 mouse MLKL 74568 Q9D2Y4 Mlkl mouse S345 22996309 ELSKTQNsIsRtAKS PK_Tyr_Ser-Thr X X 37333; 17825 -Ripk3 RIPK3 Q9QZL0 mouse CAMK2D 108058 Q6PHZ2 Camk2d mouse T287 450982 sMMHRQEtVDCLkkF X 12716 -Ripk3 RIPK3 Q9QZL0 mouse RIPK3 56532 Q9QZL0 Ripk3 mouse T231 27928506 EAELVDKtsLIRETV Pkinase X X 57220; 91702 -Ripk3 RIPK3 Q9QZL0 mouse MLKL 74568 Q9D2Y4 Mlkl mouse S347 29611200 SKTQNsIsRtAKSTK PK_Tyr_Ser-Thr X -MOS MOS P00540 human Vimentin 7431 P08670 VIM human S459 470128 GQVINEtsQHHDDLE X -MOS MOS P00540 human Vimentin 7431 P08670 VIM human T458 471089 DGQVINEtsQHHDDL X -MOS MOS P00540 human MEK1 100009316 P29678 MAP2K1 rabbit S218 448514 VSGQLIDsMANsFVG Pkinase X 9121; 3958; 9154; 86128 -MOS MOS P00540 human MEK1 100009316 P29678 MAP2K1 rabbit S222 448513 LIDsMANsFVGTRSY Pkinase X 2338; 9121; 3958; 9154; 16211; 86128; 16780; 75262 -MOS MOS P00540 human MOS 17451 P00536 Mos mouse S3 448658 _____MPsPLSLCRY X -Tec TEC P24604 mouse MAF 17132 P54843 Maf mouse Y21 25673104 TSPLAMEyVNDFDLM X -Tec TEC P24604 mouse MAF 17132 P54843 Maf mouse Y131 25673103 LQGGFDGyARGAQQL X -Tec TEC P24604 mouse MAF 17132 P54843 Maf mouse Y92 25673105 KAHLEDYyWMTGYPQ Maf_N X -Prkcz PKCZ Q02956 mouse PRKD1 18760 Q62101 Prkd1 mouse S744 448589 ARIIGEksFRRsVVG Pkinase X 2054 -Prkcz PKCZ Q02956 mouse NR0B2 23957 Q62227 Nr0b2 mouse T58 28702400 RLCAPHRtCREALDV Hormone_recep X -Prkcz PKCZ Q02956 mouse CBP 12914 P45481 Crebbp mouse S436 447689 CLPLKNAsDKRNQQT X -Prkcz PKCZ Q02956 mouse AS160 210789 Q8BYJ6 Tbc1d4 mouse S595 455920 RMRGRLGsMDsFERA X 8730 -Prkcz PKCZ Q02956 mouse PAR3-alpha 81918 Q9Z340 Pard3 rat S827 467266 REGFGRQsMSEKRtK X -Prkcz PKCZ Q02956 mouse PRKD1 18760 Q62101 Prkd1 mouse S748 448590 GEksFRRsVVGtPAy Pkinase X 2054 -Prkcz PKCZ Q02956 mouse PIN1 23988 Q9QUR7 Pin1 mouse S16 447772 PGWEkRMsRSSGRVY WW X X -Prkcz PKCZ Q02956 mouse DAB2 13132 P98078 Dab2 mouse S24 451211 QAAPKAPsKKEKKKG X -Prkcz PKCZ Q02956 mouse SQSTM1 18412 Q64337 Sqstm1 mouse S351 14580829 SsKEVDPsTGELQsL X 95697; 16177; 12074 -Prkcz PKCZ Q02956 mouse P70S6KB 6199 Q9UBS0 RPS6KB2 human S473 450071 PPSGTKKsKRGRGRP X -Prkcz PKCZ Q02956 mouse CTNNB1 12387 Q02248 Ctnnb1 mouse S45 447488 GATtTAPsLsGkGNP X 9565; 9564; 24710; 70034; 19807; 96727; 77605 -Prkcz PKCZ Q02956 mouse TRAF2 22030 P39429 Traf2 mouse T117 471341 DGCTWKGtLKEYESC X X -Prkcz PKCZ Q02956 mouse PKCZ 18762 Q02956 Prkcz mouse T560 447572 TSEPVQLtPDDEDVI Pkinase_C X -Prkcz PKCZ Q02956 mouse NFkB-p65 19697 Q04207 Rela mouse S311 449966 RTYETFksIMKKSPF X X -Prkcz PKCZ Q02956 mouse JAM-A 16456 O88792 F11r mouse S285 467829 kVIysQPstRsEGEF X -Prkcz PKCZ Q02956 mouse NUMB 18222 Q9QZS3 Numb mouse S295 470030 sPFKRQLsLRINELP NumbF X -TRIB2 TRB2 Q92519 human PKM 5315 P14618 PKM human S37 476070 MCRLDIDsPPItARN X X - TGFBR2 no information TGFBR1 7046 P36897 TGFBR1 human Y182 7791190 TtLkDLIyDMttsGs TGF_beta_GS X -MAP4K3 KHS2 Q8IVH8 human ACE2 59272 Q9BYF1 ACE2 human S783 23078777 sGENPyAsIDIsKGE X X -MAP4K3 KHS2 Q8IVH8 human TFEB 7942 P19484 TFEB human S3 54467500 _____MAsRIGLrMQ X -MAP4K3 KHS2 Q8IVH8 human KHS2 8491 Q8IVH8 MAP4K3 human S170 12655400 AtIAkRKsFIGTPYW Pkinase X X -MAP4K3 KHS2 Q8IVH8 human IQGAP1 8826 P46940 IQGAP1 human S480 1869135500 NTVWKQLsSSVTGLT X X -MAP4K3 KHS2 Q8IVH8 human PKCT 5588 Q04759 PRKCQ human T538 447907 LGDAktNtFCGtPDy Pkinase X X 9379; 9377; 2060; 38938 -MAP4K3 KHS2 Q8IVH8 human ACE2 59272 Q9BYF1 ACE2 human S776 1880091000 KkkNkARsGENPyAs X X -MAP4K3 KHS2 Q8IVH8 human IKKB 3551 O14920 IKBKB human S733 5014908 TVREQDQsFtALDWs IKKbetaNEMObind X X -Prkg1 PKG1 iso2 P0C605-2 mouse VASP 22323 P70460 Vasp mouse S153 448379 EHMERRVsNAGGPPA X X 3111; 84519 -Prkg1 PKG1 iso2 P0C605-2 mouse Lasp-1 16796 Q61792 Lasp1 mouse T156 454432 SSSYRRPtEQQQPQP X -FAM20C FAM20C Q8IXL6 human FGF23 8074 Q9GZV9 FGF23 human S180 33365504 IPRRHtRsAEDDSER X X -FAM20C FAM20C Q8IXL6 human PDIA1 5034 P07237 P4HB human S357 56652490 KIKPHLMsQELPEDW X -FAM20C FAM20C Q8IXL6 human FETUA 197 P02765 AHSG human S330 467425 VVsLGsPsGEVsHPR X -FAM20C FAM20C Q8IXL6 human FAM20C 56975 Q8IXL6 FAM20C human S106 1874398900 SsNLSSHsLEKLPPA X -FAM20C FAM20C Q8IXL6 human 7B2 25719 P27682 Scg5 rat T97 40411700 PNIVAELtGDNIPKD Secretogranin_V X -FAM20C FAM20C Q8IXL6 human PCSK9 255738 Q8NBP7 PCSK9 human S47 2811403 ELVLALRsEEDGLAE X X -FAM20C FAM20C Q8IXL6 human VWF 7450 P04275 VWF human S1517 1867984204 GEADFNRsKEFMEEV VWA X -FAM20C FAM20C Q8IXL6 human HRC 3270 P23327 HRC human S96 34499322 EKEDEDVsKEyGHLL X -FAM20C FAM20C Q8IXL6 human PCSK7 9159 Q16549 PCSK7 human S505 1827354800 AIPQSPRsLEVLWNV X -FAM20C FAM20C Q8IXL6 human 7B2 25719 P27682 Scg5 rat T135 25728419 CLENAPDtAEFsREF Secretogranin_V X -FAM20C FAM20C Q8IXL6 human ERO1L 30001 Q96HE7 ERO1A human S145 36122817 GAVDEsLsEETQkAV ERO1 X -FAM20C FAM20C Q8IXL6 human VWF 7450 P04275 VWF human S1613 1867984205 MVTGNPAsDEIKRLP VWA X -Mapk14 P38A P47811 mouse ULK1 22241 O70405 Ulk1 mouse S757 483139 PVVFtVGsPPsGAtP X 14202; 6888; 29313 -Mapk14 P38A P47811 mouse ATG5 11793 Q99J83 Atg5 mouse T75 27138202 IWFEYEGtPLKWHYP X -Mapk14 P38A P47811 mouse FOXO1A 56458 Q9R1E0 Foxo1 mouse S475 478372 PPHNDIMsPVDPGVA FOXO_KIX_bdg X X -Mapk14 P38A P47811 mouse hnRNP H1 59013 O35737 Hnrnph1 mouse S104 455395 LKHtGPNsPDtANDG X -Mapk14 P38A P47811 mouse ATF-2 1386 P15336 ATF2 human T69 448224 sVIVADQtPtPtRFL X 9225; 94125; 40749; 61584; 44167 -Mapk14 P38A P47811 mouse FOXO1A 56458 Q9R1E0 Foxo1 mouse S326 448076 stISGRLsPIMtEQD X -Mapk14 P38A P47811 mouse ATF-2 1386 P15336 ATF2 human T71 448225 IVADQtPtPtRFLkN X 9225; 9221; 5112; 94125; 13850; 40749; 15411; 24329; 61584; 27934; 92109; 20534; 35858 -Mapk14 P38A P47811 mouse K8 16691 P11679 Krt8 mouse S80 448539 TVNQSLLsPLkLEVD Keratin_2_head X -Mapk14 P38A P47811 mouse P38A 26416 P47811 Mapk14 mouse T180 447970 RHtDDEMtGyVAtRW Pkinase X 9211; 9215; 4551; 9216; 4552; 4631; 4511; 4092; 9219; 24678; 8632; 6908; 41768; 51255; 14594; 14598; 62979 -Mapk14 P38A P47811 mouse PSMD1 5707 Q99460 PSMD1 human T273 452931 QNLRtVGtPIAsVPG X X -Mapk14 P38A P47811 mouse K8 16691 P11679 Krt8 mouse S438 448540 sSYGGLTsPGFSYGM X -Mapk14 P38A P47811 mouse FOXO1A 56458 Q9R1E0 Foxo1 mouse S429 478370 TYGQSSMsPLPQMPM FOXO_KIX_bdg X -Mapk14 P38A P47811 mouse Myf-6 17878 P15375 Myf6 mouse S31 2907504 PLEVAEGsPLYPGSD Basic X -Mapk14 P38A P47811 mouse FOXO1A 56458 Q9R1E0 Foxo1 mouse T557 478373 NRLtPVKtPLQVPLS X -Mapk14 P38A P47811 mouse PRDX6 11758 O08709 Prdx6 mouse T93 484030 INAyNGEtPTEkLPF AhpC-TSA X X -Mapk14 P38A P47811 mouse GR 2908 P04150 NR3C1 human S134 3178932 ANLNRstsVPENPkS GCR X 85060 -Mapk14 P38A P47811 mouse MITF iso8 17342 Q08874-8 Mitf mouse S307 451221 IPSTGLCsPDLVNRI DUF3371 X X -Mapk14 P38A P47811 mouse TAB3 257397 Q8N5C8 TAB3 human T404 1295506 HSLYTATtPPSssPS X -Mapk14 P38A P47811 mouse XBP1 22433 O35426 Xbp1 mouse S61 21688102 RQRLTHLsPEEKALR bZIP_1 X -Mapk14 P38A P47811 mouse RARG iso2 19411 P18911-2 Rarg mouse S68 455544 EMVPSsPsPPPPPRV X -Mapk14 P38A P47811 mouse AHNAK 66395 E9Q616 Ahnak mouse S5555 452765 KPRHRsNsFsDEREF X -Mapk14 P38A P47811 mouse osterix 170574 Q8VI67 Sp7 mouse S73 15334100 SSTNGLLsPAGsPPA X X -Mapk14 P38A P47811 mouse Kv4.2 16508 Q9Z0V2 Kcnd2 mouse T607 457612 IPtPPVttPEGDDRP X -Mapk14 P38A P47811 mouse Myf-6 17878 P15375 Myf6 mouse S42 2907503 PGSDGTLsPCQDQMP Basic X -Mapk14 P38A P47811 mouse GATA3 14462 P23772 Gata3 mouse S308 456464 IKPKRRLsAARRAGT X -Mapk14 P38A P47811 mouse STAT3 20848 P42227 Stat3 mouse S727 448191 NtIDLPMsPRTLDSL X 9134; 9136; 34911; 94994; 49081; 58978; 87544; 71958; 50804 -Mapk14 P38A P47811 mouse ATF-2 11909 P16951 Atf2 mouse T51 448224 sVIVADQtPtPtRFL X X 9225; 94125; 40749; 61584; 44167 -Mapk14 P38A P47811 mouse PARK2 50873 Q9WVS6 Prkn mouse S131 454421 DTDSKRDsEAARGPV X -Mapk14 P38A P47811 mouse FOXO1A 56458 Q9R1E0 Foxo1 mouse S413 478368 PPNTSLNsPsPNYSK X -Mapk14 P38A P47811 mouse p53 22059 P02340 Tp53 mouse S18 447490 IsLELPLsQEtFsGL P53_TAD X X 9284; 9286; 12571; 56979 -Mapk14 P38A P47811 mouse p21Cip1 1026 P38936 CDKN1A human S130 455618 sGEQAEGsPGGPGDs X -Mapk14 P38A P47811 mouse AHNAK 66395 E9Q616 Ahnak mouse S5566 3148527 EREFsAPstPtGtLE X -Mapk14 P38A P47811 mouse hnRNP H2 56258 P70333 Hnrnph2 mouse S104 455396 LKHtGPNsPDtANDG X -Mapk14 P38A P47811 mouse osterix 170574 Q8VI67 Sp7 mouse S77 15334101 GLLsPAGsPPAPASG X X -Mapk14 P38A P47811 mouse IWS1 73473 Q8C1D8 Iws1 mouse S183 4756568 EPPKPRIsDsEsEEL X X -Mapk14 P38A P47811 mouse H3 iso3 15081 P84244 H3f3b mouse S28 455677 ATkAArksAPSTGGV Histone X 9713 -Mapk14 P38A P47811 mouse Myb 17863 P06876 Myb mouse T486 1308921 PLKMLPQtPSHAVED Cmyb_C X -Mapk14 P38A P47811 mouse STAT4 20849 P42228 Stat4 mouse S722 447789 PSDLLPMsPSAYAVL X X -Mapk14 P38A P47811 mouse RARG iso2 19411 P18911-2 Rarg mouse S66 455543 SEEMVPSsPsPPPPP X -Mapk14 P38A P47811 mouse NFAT3 73181 Q8K120 Nfatc4 mouse S170 448860 GGAFFsPsPGSSSLS X -Mapk14 P38A P47811 mouse E2A 21423 P15806 Tcf3 mouse S140 455905 LSsPGPLsPSGIKSS X X -Mapk14 P38A P47811 mouse PGRMC1 53328 O55022 Pgrmc1 mouse S181 452525 GEEPtVysDDEEPKD X X -Mapk14 P38A P47811 mouse P38A 26416 P47811 Mapk14 mouse Y182 447971 tDDEMtGyVAtRWYR Pkinase X 9211; 9215; 4551; 9216; 4552; 4631; 4511; 4092; 9219; 24678; 8632; 6908; 41768; 51255; 14594; 14598; 62979 -Mapk14 P38A P47811 mouse ATF-2 11909 P16951 Atf2 mouse T53 448225 IVADQtPtPtRFLKN X 9225; 9221; 5112; 94125; 13850; 40749; 15411; 24329; 61584; 27934; 92109; 20534; 35858 -Mapk14 P38A P47811 mouse FOXO1A 56458 Q9R1E0 Foxo1 mouse S467 478371 KELLtsDsPPHNDIM FOXO_KIX_bdg X X -Mapk14 P38A P47811 mouse XBP1 22433 O35426 Xbp1 mouse T48 21688103 AGSEASGtPQARKRQ X -Mapk14 P38A P47811 mouse Tip60 iso2 10524 Q92993-2 KAT5 human T106 10800707 VEVVsPAtPVPSETA X -Mapk14 P38A P47811 mouse ZC3H10 103284 Q8R205 Zc3h10 mouse S126 36133857 VAAGLGLsPADLPNG X -Mapk14 P38A P47811 mouse AHNAK 66395 E9Q616 Ahnak mouse S4906 7103416 VPDVDIssPGINVEA X X -Mapk14 P38A P47811 mouse CLIC1 114584 Q9Z1Q5 Clic1 mouse S146 15408945 VLDNYLTsPLPEEVD GST_C_2 X -Mapk14 P38A P47811 mouse C/EBP-beta 12608 P28033 Cebpb mouse T188 447878 sSssPPGtPSPADAK X 3084 -Mapk14 P38A P47811 mouse Mtres1 67851 Q9CQF4 Mtres1 mouse S106 457079 KEADEEDsDEETsyP X -Mapk14 P38A P47811 mouse RANBP2 19386 Q9ERU9 Ranbp2 mouse S2505 468573 KNRPGyVsEEEEDDE IR1-M X -Mapk14 P38A P47811 mouse AQP2 11827 P56402 Aqp2 mouse S261 464644 RQsVELHsPQsLPRG X -Mapk14 P38A P47811 mouse NFAT1 18019 Q60591 Nfatc2 mouse S79 628303302 CNPLASLsGEPPGRF X -Mapk14 P38A P47811 mouse FOXO1A 56458 Q9R1E0 Foxo1 mouse S284 478910 GQEGPGDsPGSQFSK X -Mapk14 P38A P47811 mouse CRYAB 12955 P23927 Cryab mouse S59 448783 PSFLRAPsWIDtGLS X -Mapk14 P38A P47811 mouse Akt1 11651 P31750 Akt1 mouse S473 447855 RPHFPQFsysAsGtA Pkinase_C X 9271; 3787; 4060; 4051; 5102; 4058; 2336; 2337; 4075; 4070; 5012; 4071; 92982; 5315; 9563; 9018; 12694; 52240; 11962; 15116; 88106; 26580; 68035; 31957; 23430; 20235 -Mapk14 P38A P47811 mouse SCN8A 29710 O88420 Scn8a rat S553 456209 SLLSIPGsPFLSRHN Na_trans_cytopl X -Mapk14 P38A P47811 mouse TAB3 257397 Q8N5C8 TAB3 human S60 1295505 yLyMEyHsPDDNRMN X -Mapk14 P38A P47811 mouse GRP78 14828 P20029 Hspa5 mouse T649 4704207 PPtGEEDtsEKDEL_ X X -Mapk14 P38A P47811 mouse FAM65A 75687 Q68FE6 Ripor1 mouse S875 4734442 PGDRHTssPEVVAED X -Mapk14 P38A P47811 mouse ASS1 11898 P16460 Ass1 mouse S219 4703613 DPAkAPNsPDVLEIE Arginosuc_synth X -Mapk14 P38A P47811 mouse NFAT3 73181 Q8K120 Nfatc4 mouse S168 448859 QGGGAFFsPsPGSSS X -Mapk14 P38A P47811 mouse Akt1 11651 P31750 Akt1 mouse T308 447856 KDGAtMKtFCGtPEy Pkinase X 5106; 2965; 9275; 4056; 5056; 13842; 13038; 43506; 48646; 86758; 80722; 77440; 80556 -Mapk14 P38A P47811 mouse FOXO1A 56458 Q9R1E0 Foxo1 mouse S295 471972 QFSKWPAsPGSHsND X -Mapk14 P38A P47811 mouse IWS1 73473 Q8C1D8 Iws1 mouse S185 453543 PKPRIsDsEsEELPK X X -Mapk14 P38A P47811 mouse Tip60 10524 Q92993 KAT5 human T158 10800707 VEVVsPAtPVPSETA X -Mapk14 P38A P47811 mouse STAT1 20846 P42225 Stat1 mouse S727 447753 tDNLLPMsPEEFDEM STAT1_TAZ2bind X 9177; 8826; 62390 -Mapk14 P38A P47811 mouse SMARCD3 66993 Q6P9Z1 Smarcd3 mouse T229 8097074 HLVEWHRtPTTQETD X -Mapk14 P38A P47811 mouse Mtres1 67851 Q9CQF4 Mtres1 mouse S116 3214449 ETsyPERsEQEEELE X -Prkcd PKCD P09215 rat PLCB3 29322 Q99JE6 Plcb3 rat S1105 448448 LDRKRNNsISEAKTR PLC-beta_C X 2484 -Prkcd PKCD P09215 rat PKCD 170538 P09215 Prkcd rat S662 447580 QtAFKGFsFVNPKYE Pkinase_C X 9371 -Prkcd PKCD P09215 rat PRKD1 85421 Q9WTQ1 Prkd1 rat S748 448590 GEKsFRRsVVGTPAY Pkinase X -Prkcd PKCD P09215 rat TNNI3 29248 P23693 Tnni3 rat S23 448423 PAPVRRRssANYRAY Troponin-I_N X 4004 -Prkcd PKCD P09215 rat 14-3-3 eta 22629 P68510 Ywhah mouse S59 450482 VVGARRSsWRVIssI 14-3-3 X 52631 -Prkcd PKCD P09215 rat 14-3-3 beta 54401 Q9CQV8 Ywhab mouse S60 450226 VVGARRSsWRVIssI 14-3-3 X 52631 -Prkcd PKCD P09215 rat TNNI3 29248 P23693 Tnni3 rat T144 451483 RGKFkRPtLRRVRIs Troponin X -Prkcd PKCD P09215 rat IRS1 25467 P35570 Irs1 rat S357 4859802 HAHRHRGssRLHPPL X -Prkcd PKCD P09215 rat VGCNL1 266760 Q6Q760 Nalcn rat S1653 1869465802 TLSDRGGsRQDAADT X -Prkcd PKCD P09215 rat PLSCR1 5359 O15162 PLSCR1 human T161 11380906 CGPSRPFtLRIIDNM Scramblase X -Prkcd PKCD P09215 rat KLF4 114505 Q923V7 Klf4 rat T400 22996305 RKRTATHtCDYAGCG zf-C2H2 X -Prkcd PKCD P09215 rat CKM 24265 P00564 Ckm rat S128 5410301 LDPNyVLssRVRTGR X -Prkcd PKCD P09215 rat 14-3-3 zeta 22631 P63101 Ywhaz mouse S58 449833 VVGARRSsWRVVSsI 14-3-3 X 52631 -Prkcd PKCD P09215 rat PRKD1 85421 Q9WTQ1 Prkd1 rat S744 448589 ARIIGEKsFRRsVVG Pkinase X -Prkcd PKCD P09215 rat GRK2 156 P25098 GRK2 human S29 447724 ATPAARAskkILLPE X -Prkcd PKCD P09215 rat Ebp1 288778 Q6AYD3 Pa2g4 rat S360 478276 ELKALLQsSASRKTQ X -Prkcd PKCD P09215 rat TNNI3 29248 P23693 Tnni3 rat S24 448424 APVRRRssANYRAYA Troponin-I_N X 4004 -Prkcd PKCD P09215 rat G-gamma 12 14701 Q9DAS9 Gng12 mouse S2 447876 ______MssktAstN X -Ilk ILK O55222 mouse ILK 16202 O55222 Ilk mouse S343 448495 SMADVKFsFQCPGRM PK_Tyr_Ser-Thr X -EPHA4 EphA4 P54764 human ephexin-1 53972 Q8CHT1 Ngef mouse Y177 455579 IEQIGLLyQEyRDKS X -EPHA4 EphA4 P54764 human EphA4 2043 P54764 EPHA4 human Y779 450858 EDDPEAAyTtRGGKI PK_Tyr_Ser-Thr X 8793; 8862 -EPHA4 EphA4 P54764 human EphA4 2043 P54764 EPHA4 human Y602 450857 tyVDPFtyEDPNQAV EphA2_TM X -EPHA4 EphA4 P54764 human GMPR 2766 P36959 GMPR human Y267 1005248 GRKLKLFyGMssDtA IMPDH X X -EPHA4 EphA4 P54764 human PAR3-alpha 81918 Q9Z340 Pard3 rat Y1080 454961 RQARERDyAEIQDFH X -EPHA4 EphA4 P54764 human PAR3-alpha 81918 Q9Z340 Pard3 rat Y1127 457508 GHLMDTLyAQVKKPR X X -EPHA4 EphA4 P54764 human EphA4 2043 P54764 EPHA4 human Y596 450856 LNQGVRtyVDPFtyE EphA2_TM X -Hck Hck P08103 mouse Hck 15162 P08103 Hck mouse Y409 448168 RIIEDNEytAREGAK PK_Tyr_Ser-Thr X X 2101; 6943; 59548; 70926; 78740; 94361; 17320 -Hck Hck P08103 mouse Abl 11350 P00520 Abl1 mouse Y393 450298 RLMTGDTytAHAGAK PK_Tyr_Ser-Thr X 2865 -Hck Hck P08103 mouse PKCD 18753 P28867 Prkcd mouse Y523 450231 EILQGLKySFSVDWW Pkinase X X -Hck Hck P08103 mouse PKCD 18753 P28867 Prkcd mouse Y311 447573 TTEsVGIyQGFEKKP X 2055 -Hck Hck P08103 mouse Hck 15162 P08103 Hck mouse Y50 448169 ANQKGPVyVPDPTSS X X -Hck Hck P08103 mouse WASP 7454 P42768 WAS human Y291 447985 AEtsKLIyDFIEDQG PBD X X -Chuk IKKA Q60680 mouse IkB-alpha 18035 Q9Z1E3 Nfkbia mouse S32 448203 LVDDRHDsGLDsMKD X 5210; 2859; 9246; 5209 -Chuk IKKA Q60680 mouse RORC iso2 19885 P51450-2 Rorc mouse S376 139835702 GCSELISsIFDFSHF Hormone_recep X -Chuk IKKA Q60680 mouse p27Kip1 12576 P46414 Cdkn1b mouse T183 23128659 DGsPNAGtVEQtPKK X -Chuk IKKA Q60680 mouse p27Kip1 12576 P46414 Cdkn1b mouse S12 9316305 RVsNGsPsLERMDAR X -Chuk IKKA Q60680 mouse p27Kip1 12576 P46414 Cdkn1b mouse S178 450208 EENVsDGsPNAGtVE X -Chuk IKKA Q60680 mouse p27Kip1 12576 P46414 Cdkn1b mouse T42 28058802 PVNHEELtRDLEKHC CDI X -Chuk IKKA Q60680 mouse IkB-alpha 18035 Q9Z1E3 Nfkbia mouse S36 448204 RHDsGLDsMKDEEYE X 5210; 9246 -Chuk IKKA Q60680 mouse IRS1 16367 P35569 Irs1 mouse S307 447558 tEsITAtsPAsMVGG X 2381 -Chuk IKKA Q60680 mouse p27Kip1 12576 P46414 Cdkn1b mouse S175 28058801 NRtEENVsDGsPNAG X -Chuk IKKA Q60680 mouse H3 iso3 15081 P84244 H3f3b mouse S10 455676 tKQTARksTGGkAPR Histone X X 9701; 9711; 9706; 3465; 3642; 3377; 3475; 3458; 5764; 47398; 8481; 8552; 53348; 29237; 66065; 43185; 64522; 52725 -Chuk IKKA Q60680 mouse NFkB-p65 19697 Q04207 Rela mouse S534 447800 sGDEDFssIADMDFS X X 4887; 3036; 3031; 4886; 3033; 4025; 5733; 13346; 76778; 31553; 80477; 73992; 87672; 83962 -SRPK2 SRPK2 P78362 human RIMS1 84556 Q9JIR4 Rims1 rat S413 450481 ARHERRHsDVALPHT X -SRPK2 SRPK2 P78362 human RIMS1 84556 Q9JIR4 Rims1 rat S1078 4725320 RPDTSLHsPERERHS X -SRPK2 SRPK2 P78362 human RIMS1 84556 Q9JIR4 Rims1 rat S287 455664 KQASRSRsEPPRERK X -SRPK2 SRPK2 P78362 human LGMN 5641 Q99538 LGMN human S226 183811000 CYYDEkRsTYLGDWY Peptidase_C13 X X -SRPK2 SRPK2 P78362 human SRPK2 20817 O54781 Srpk2 mouse T485 483237 PsHDRsRtVsAsstG X -SRPK2 SRPK2 P78362 human RIMS1 84556 Q9JIR4 Rims1 rat S447 2761601 ARVsPPEsPRARAAA X -SRPK2 SRPK2 P78362 human RIMS1 84556 Q9JIR4 Rims1 rat S1045 4725312 PRAKRGRsAESLHMT X -SRPK2 SRPK2 P78362 human acinus 22985 Q9UKV3 ACIN1 human S1180 456759 GPRsRsRsRDRRRKE RSB_motif X X -SRPK2 SRPK2 P78362 human RIMS1 84556 Q9JIR4 Rims1 rat S514 4772463 ESMLRNDsLSSDQSE X -SRPK2 SRPK2 P78362 human SRPK2 6733 P78362 SRPK2 human S494 483631 HDRSRtVsAsstGDL X -SRPK2 SRPK2 P78362 human Tau 4137 P10636 MAPT human S214 3847081 GGKERPGsKEEVDED X X -SRPK2 SRPK2 P78362 human RIMS1 84556 Q9JIR4 Rims1 rat S1066 3926128 LDRARSAsTNCLRPD X -CDK11A CDK11A iso10 Q9UQ88-10 human CDK11B iso12 984 P21127-12 CDK11B human T370 17671300 KHEYFREtPLPIDPS X X -PRKX PRKX P51817 human SMAD6 4091 O43541 SMAD6 human S435 460301 RKVPPGYsIKVFDFE MH2 X -PRKX PRKX P51817 human PKD1 5310 P98161 PKD1 human S4166 2859800 EPLPSRSsRGsKVSP X X -Camk2d CAMK2D P15791 rat SCN5A 6331 Q14524 SCN5A human T594 25244201 LHGkKNStVDCNGVV Na_trans_cytopl X -Camk2d CAMK2D P15791 rat CACNB1 50688 P54283 Cacnb1 rat T499 471963 WALSRQDtFDADTPG X -Camk2d CAMK2D P15791 rat CACNB2 iso2 116600 Q8VGC3-2 Cacnb2 rat T498 470081 RGLSRQEtFDSETQE X X -Camk2d CAMK2D P15791 rat SCN5A 6331 Q14524 SCN5A human S516 4719558 LsLTrGLsRTsMKPR Na_trans_cytopl X -Camk2d CAMK2D P15791 rat RYR2 689560 B0LPN4 Ryr2 rat S2798 448848 yNRTRRIsQTsQVsI X -Camk2d CAMK2D P15791 rat PLB 64672 P61016 Pln rat T17 448115 SAIRRAstIEMPQQA Phospholamban X 8496 -Camk2d CAMK2D P15791 rat CAMK2D 24246 P15791 Camk2d rat T287 450982 sMMHRQEtVDCLkkF X X 12716 -DYRK1A DYRK1A P85051 rabbit FOXO1A 2308 Q12778 FOXO1 human S329 448076 stIsGRLsPIMtEQD X -MAPK6 ERK3 Q16659 human SRC-3 8202 Q9Y6Q9 NCOA3 human S857 453084 PPYNRAVsLDsPVsV X X -MAPK6 ERK3 Q16659 human supervillin 6840 O95425 SVIL human S245 468887 sFtEVPRsPKHAHSS X X -MAPK6 ERK3 Q16659 human Arp3 10096 P61158 ACTR3 human S418 480945 NPVFGVMs_______ X X -MAPK6 ERK3 Q16659 human ERK3 5597 Q16659 MAPK6 human S189 448267 ySHKGHLsEGLVTkW Pkinase X -MAPK6 ERK3 Q16659 human TTRAP 51567 O95551 TDP2 human S60 52421901 EMERALNsyFEPPVE UBA_4 X -Prkg1 PKG1 P0C605 mouse KCNMA1 iso5 16531 Q08460-5 Kcnma1 mouse S873 469989 HGMLRQPsITTGVNI X X -Prkg1 PKG1 P0C605 mouse SMAD3 17127 Q8BUN5 Smad3 mouse T388 1243500 GAEYRRQtVTSTPCW MH2 X -Prkg1 PKG1 P0C605 mouse SMAD3 17127 Q8BUN5 Smad3 mouse S309 1243501 EVFAECLsDSAIFVQ MH2 X -Prkg1 PKG1 P0C605 mouse PKG1 iso2 19091 P0C605-2 Prkg1 mouse S81 51573802 RTKRQAIsAEPTAFD X -Prkg1 PKG1 P0C605 mouse RHOA 11848 Q9QUI0 Rhoa mouse S188 449035 ARRGKKKsGCLIL__ X -Prkg1 PKG1 P0C605 mouse PKG1 19091 P0C605 Prkg1 mouse T59 448837 THIGPRTtRAQGISA X -Prkg1 PKG1 P0C605 mouse GABRB1 14400 P50571 Gabrb1 mouse S434 450244 GRIRRRAsQLKVKIP Neur_chan_memb X -Prkg1 PKG1 P0C605 mouse Lasp-1 16796 Q61792 Lasp1 mouse T156 454432 SSSYRRPtEQQQPQP X -Prkg1 PKG1 P0C605 mouse BAD 12015 Q61337 Bad mouse S155 447863 GRELRRMsDEFEGsF Bcl-2_BAD X 9297 -Prkg1 PKG1 P0C605 mouse TRPC6 22068 Q61143 Trpc6 mouse T69 470868 RLTHRRQtILREKGR X -Prkg1 PKG1 P0C605 mouse KCNMA1 iso5 16531 Q08460-5 Kcnma1 mouse S1112 466425 QSSSKKSsSVHSIPS X -Prkg1 PKG1 P0C605 mouse GSBS Q8CJC8 Gsbs rat T123 2999004 KRPRRKDtPAFHVPP X -Prkg1 PKG1 P0C605 mouse PKG1 19091 P0C605 Prkg1 mouse T85 452151 RQAFRKFtKSERSKD X -Prkg1 PKG1 P0C605 mouse KCNMA1 iso5 16531 Q08460-5 Kcnma1 mouse S692 27842903 SNVKKYDsTGMFHWC X X -Prkg1 PKG1 P0C605 mouse PDE5A 242202 Q8CG03 Pde5a mouse S92 448178 GAPARKIsASEFDRP X -Prkg1 PKG1 P0C605 mouse GSBS Q8CJC8 Gsbs rat T72 2999005 KKPRRKDtPALHIPP X -Prkg1 PKG1 P0C605 mouse PKG1 iso2 19091 P0C605-2 Prkg1 mouse T58 34434401 RSVIRPAtQQAQKQs X -Prkg1 PKG1 P0C605 mouse PKG1 iso2 19091 P0C605-2 Prkg1 mouse S65 1870119329 tQQAQKQsAsTLQGE X -Prkg1 PKG1 P0C605 mouse HSP20 126393 O14558 HSPB6 human S16 450706 PSWLRRAsAPLPGLS Crystallin X 36519 -CAMK2G CAMK2G Q13555 human BAD 12015 Q61337 Bad mouse S170 447864 KGLPRPKsAGtATQM Bcl-2_BAD X -CAMK2G CAMK2G Q13555 human CAMK2G 818 Q13555 CAMK2G human S319 2874405 RNFsAAKsLLNKKsD X -CAMK2G CAMK2G Q13555 human ITPKB 3707 P27987 ITPKB human S174 3189511 PRLGRARsPsPCPFR X X -CAMK2G CAMK2G Q13555 human CAMK2G 818 Q13555 CAMK2G human S280 481026 CQRsTVAsMMHRQEt X -CAMK2G CAMK2G Q13555 human DAB2 1601 P98082 DAB2 human S723 18008467 KPAPRQVsLPVTkst X -CAMK2G CAMK2G Q13555 human LXR-beta 7376 P55055 NR1H2 human S426 18502600 RMLMKLVsLRTLsSV Hormone_recep X -CAMK2G CAMK2G Q13555 human occludin 100506658 Q16625 OCLN human S471 6094301 LDDyREEsEEyMAAA Occludin_ELL X -CAMK2G CAMK2G Q13555 human CACNA1H 8912 O95180 CACNA1H human S1198 22648004 tPLRRAEsLDPRPLR X -Gucy2e GUCY2D P52785 mouse GUCY2D 14919 P52785 Gucy2e mouse S538 11502404 RssLATRsASDIRSV X -Gucy2e GUCY2D P52785 mouse GUCY2D 14919 P52785 Gucy2e mouse S530 11502403 SRKVVQGsRssLATR X -Gucy2e GUCY2D P52785 mouse GUCY2D 14919 P52785 Gucy2e mouse S533 11502406 VVQGsRssLATRsAS X -Gucy2e GUCY2D P52785 mouse GUCY2D 14919 P52785 Gucy2e mouse S532 11502405 KVVQGsRssLATRsA X -PDK1 PDHK1 Q15118 human PDHA1 100294678 P29804 PDHA1 pig S231 448257 NRYGMGTsVERAAAS E1_dh X -PDK1 PDHK1 Q15118 human PDHA1 5160 P08559 PDHA1 human S300 448259 sMsDPGVsyRtREEI E1_dh X X -PDK1 PDHK1 Q15118 human PDHA1 18597 P35486 Pdha1 mouse S293 448258 TYRyHGHsMsDPGVs E1_dh X 31866; 37115; 48447 -PDK1 PDHK1 Q15118 human PDHA1 5160 P08559 PDHA1 human S293 448258 TYRyHGHsMsDPGVs E1_dh X X 31866; 37115; 48447 -PDK1 PDHK1 Q15118 human PDHA2 5161 P29803 PDHA2 human S298 458870 sMsDPGVsyRtREEI E1_dh X -PDK1 PDHK1 Q15118 human PDHA1 100294678 P29804 PDHA1 pig S299 448259 sMSDPGVsYRTREEI E1_dh X -PDK1 PDHK1 Q15118 human PDHA1 100294678 P29804 PDHA1 pig S292 448258 TYRYHGHsMSDPGVs E1_dh X 31866; 37115; 48447 -PDK1 PDHK1 Q15118 human PDHA1 5160 P08559 PDHA1 human S232 448257 NRyGMGtsVERAAAs E1_dh X X 15289 -PDK1 PDHK1 Q15118 human PDHA2 5161 P29803 PDHA2 human S291 458869 TYRyHGHsMsDPGVs E1_dh X 31866; 37115; 48447 -PDK1 PDHK1 Q15118 human PDHA2 5161 P29803 PDHA2 human S230 458871 NLYGMGTsTERAAAS E1_dh X -PDK1 PDHK1 Q15118 human PDHA1 18597 P35486 Pdha1 mouse S232 448257 NRyGMGtsVERAAAS E1_dh X -MAPK8 JNK1 P45983 human SIRT1 23411 Q96EB6 SIRT1 human S47 452899 DGPGLERsPGEPGGA X X 2314 -MAPK8 JNK1 P45983 human YAP1 iso3 10413 P46937-3 YAP1 human T154 3190681 VVSGPAAtPTAQHLR X -MAPK8 JNK1 P45983 human STMN2 84510 P21818 Stmn2 rat S62 450174 ELILKPPsPISEAPR Stathmin X -MAPK8 JNK1 P45983 human Tau iso8 4137 P10636-8 MAPT human T231 449079 KKVAVVRtPPKsPss X 20473; 71429 -MAPK8 JNK1 P45983 human JunB 3726 P17275 JUNB human T102 1814001 SNGVITTtPtPPGQy Jun X 8053 -MAPK8 JNK1 P45983 human SYT4 64440 P50232 Syt4 rat S135 4706863 ETEKEAVsPESLKSS X X -MAPK8 JNK1 P45983 human STMN1 29332 P13668 Stmn1 rat S38 448556 SVPEFPLsPPKKkDL Stathmin X 3426; 4191 -MAPK8 JNK1 P45983 human 4E-T 56478 Q9NRA8 EIF4ENIF1 human S513 3213594 NLEsHLMsPAEIPGQ EIF4E-T X X -MAPK8 JNK1 P45983 human EEF1A2 1917 Q05639 EEF1A2 human S358 27930803 GQISAGYsPVIDCHT GTP_EFTU_D3 X -MAPK8 JNK1 P45983 human ATF-2 1386 P15336 ATF2 human T69 448224 sVIVADQtPtPtRFL X X 9225; 94125; 40749; 61584; 44167 -MAPK8 JNK1 P45983 human APP iso4 351 P05067-4 APP human T668 448523 VEVDAAVtPEERHLs APP_amyloid X X -MAPK8 JNK1 P45983 human FOXO3A 2309 O43524 FOXO3 human S574 20799900 SAkHQQQsPVSQSMQ X -MAPK8 JNK1 P45983 human RARA 5914 P10276 RARA human S461 455330 RSSPATHsP______ X X -MAPK8 JNK1 P45983 human LMO7 iso3 361084 Q6JBI6 Lmo7 rat S1298 483780 SVKTsPGsPsPRSHs X -MAPK8 JNK1 P45983 human ATF-2 1386 P15336 ATF2 human T71 448225 IVADQtPtPtRFLkN X X 9225; 9221; 5112; 94125; 13850; 40749; 15411; 24329; 61584; 27934; 92109; 20534; 35858 -MAPK8 JNK1 P45983 human DRPLA 1822 P54259 ATN1 human S739 450317 EEyETPEsPVPPARs Atrophin-1 X -MAPK8 JNK1 P45983 human Nur77 3164 P22736 NR4A1 human S95 471072 TSSSSATsPASASFk X X -MAPK8 JNK1 P45983 human WDR62 284403 O43379 WDR62 human T1053 460021 PsssLPQtPEQEKFL X X -MAPK8 JNK1 P45983 human SP1 6667 P08047 SP1 human T278 1988302 SVSAATLtPSSQAVT X X -MAPK8 JNK1 P45983 human BIM 12125 O54918 Bcl2l11 mouse S114 449072 DKStQtPsPPCQAFN X -MAPK8 JNK1 P45983 human SMAD2 Q1W668 SMAD2 cow S245 448794 NQSMDTGsPAELsPT X -MAPK8 JNK1 P45983 human 14-3-3 sigma 2810 P31947 SFN human S186 456054 FHYEIANsPEEAISL 14-3-3 X X -MAPK8 JNK1 P45983 human DUSP8 18218 O09112 Dusp8 mouse S520 22598804 LDsPGtPsPDGPWCF X -MAPK8 JNK1 P45983 human JIP1 9479 Q9UQF2 MAPK8IP1 human T205 449954 PLKtGEQtPPHEHIC X -MAPK8 JNK1 P45983 human 4E-T 56478 Q9NRA8 EIF4ENIF1 human S301 14572931 DAVLPEQsPGDFDFN EIF4E-T X X -MAPK8 JNK1 P45983 human RBM17 84991 Q96I25 RBM17 human S222 3209223 EEQDRPRsPtGPsNs X -MAPK8 JNK1 P45983 human JIP3 30957 Q9ESN9 Mapk8ip3 mouse T287 458343 SVPSAAVtPLNESLQ X X -MAPK8 JNK1 P45983 human LAT iso2 27040 O43561-2 LAT human T155 451994 PSAPALStPGIRDSA LAT X X -MAPK8 JNK1 P45983 human CTNNB1 12387 Q02248 Ctnnb1 mouse S191 467710 SRHAIMRsPQMVSAI X -MAPK8 JNK1 P45983 human STAT6 6778 P42226 STAT6 human S707 17772900 IPPYQGLsPEESVNV STAT6_C X X -MAPK8 JNK1 P45983 human CTBP1 1487 Q13363 CTBP1 human S422 455350 AHPPHAPsPGQTVkP X X -MAPK8 JNK1 P45983 human NRL 18185 P54846 Nrl mouse S50 478419 PYSSVPPsPTFSEPG X -MAPK8 JNK1 P45983 human NFAT3 4776 Q14934 NFATC4 human S217 953803 GLGsPLPsPRAsPRP X -MAPK8 JNK1 P45983 human JunD 3727 P17535 JUND human S100 456168 LGLLkLAsPELERLI Jun X 9164 -MAPK8 JNK1 P45983 human DUSP8 18218 O09112 Dusp8 mouse S515 22598803 GWVPPLDsPGtPsPD X -MAPK8 JNK1 P45983 human NRF2 4780 Q16236 NFE2L2 human S408 10292700 GDMVQPLsPSQGQST X -MAPK8 JNK1 P45983 human GR 24413 P06536 Nr3c1 rat S246 451796 LIDENLLsPLAGEDD GCR X X 97285 -MAPK8 JNK1 P45983 human GAP43 14432 P06837 Gap43 mouse T172 449106 VtDAAAttPAAEDAA Neuromodulin X -MAPK8 JNK1 P45983 human 4E-T 56478 Q9NRA8 EIF4ENIF1 human S693 3213600 ASITSMLsPSFTPTS EIF4E-T X X -MAPK8 JNK1 P45983 human LIMD1 8994 Q9UGP4 LIMD1 human S277 451975 RVsPGLPsPNLENGA X X -MAPK8 JNK1 P45983 human LIMD1 8994 Q9UGP4 LIMD1 human S272 451974 TASsQRVsPGLPsPN X X -MAPK8 JNK1 P45983 human CTNNB1 1499 P35222 CTNNB1 human S37 447582 yLDsGIHsGATtTAP X X 9561; 2009; 4270; 13537; 41334; 60180 -MAPK8 JNK1 P45983 human Bcl-xL 598 Q07817 BCL2L1 human T115 448162 LTSQLHItPGTAYQS Bcl-2 X -MAPK8 JNK1 P45983 human LMO7 iso3 361084 Q6JBI6 Lmo7 rat S1300 449450 KTsPGsPsPRSHsPS X -MAPK8 JNK1 P45983 human GRB7 2886 Q14451 GRB7 human S194 58912301 KyELFKssPHSLFPE X -MAPK8 JNK1 P45983 human GLE1 2733 Q53GS7 GLE1 human S99 18010022 ssAFsPAsPAtPNGT X -MAPK8 JNK1 P45983 human CDT1 81620 Q9H211 CDT1 human S391 20804632 LRSAAPssPGsPrPA X -MAPK8 JNK1 P45983 human ATF-2 1386 P15336 ATF2 human S90 467297 GLFNELAsPFENEFk X X -MAPK8 JNK1 P45983 human MCL1 4170 Q07820 MCL1 human S64 479431 IGGSAGAsPPStLtP X 13297 -MAPK8 JNK1 P45983 human CDC25C 995 P30307 CDC25C human S168 449022 SEMKyLGsPIttVPK X -MAPK8 JNK1 P45983 human Raptor 57521 Q8N122 RPTOR human S696 11315003 EKNyALPsPAttEGG X X -MAPK8 JNK1 P45983 human Tau iso8 4137 P10636-8 MAPT human S396 449081 GAEIVyKsPVVsGDt X 9632 -MAPK8 JNK1 P45983 human YAP1 iso3 10413 P46937-3 YAP1 human S317 471290 GTQNPVSsPGMSQEL X -MAPK8 JNK1 P45983 human NEIL1 79661 Q96FI4 NEIL1 human S207 36704364 ALQQHRPsPELTLSQ X -MAPK8 JNK1 P45983 human MLP 17357 P28667 Marcksl1 mouse T183 454301 PQAAEPstPsGPEsG MARCKS X -MAPK8 JNK1 P45983 human PPAR-gamma 5468 P37231 PPARG human S112 448062 AIkVEPAsPPYYSEK X -MAPK8 JNK1 P45983 human CDT1 81620 Q9H211 CDT1 human T402 20804634 PrPALPAtPPAtPPA X -MAPK8 JNK1 P45983 human BID 637 P55957 BID human T59 448406 EGyDELQtDGNRsSH BID X X -MAPK8 JNK1 P45983 human SRC-3 8202 Q9Y6Q9 NCOA3 human S860 454106 NRAVsLDsPVsVGss X -MAPK8 JNK1 P45983 human 4E-T 56478 Q9NRA8 EIF4ENIF1 human S752 26392102 PsADRDssPttNSkL X X -MAPK8 JNK1 P45983 human K8 3856 P05787 KRT8 human S74 448539 tVNQsLLsPLVLEVD Keratin_2_head X -MAPK8 JNK1 P45983 human BIM iso2 10018 O43521-2 BCL2L11 human S58 449072 DKSTQtPsPPCQAFN X X -MAPK8 JNK1 P45983 human BIM 64547 O88498 Bcl2l11 rat S55 454235 GDRCPHGsPQGPLAP X 4550 -MAPK8 JNK1 P45983 human DUSP8 18218 O09112 Dusp8 mouse T518 22598802 PPLDsPGtPsPDGPW X -MAPK8 JNK1 P45983 human APP 54226 P08592 App rat T743 448523 VEVDAAVtPEERHLS APP_amyloid X X 3823; 6986 -MAPK8 JNK1 P45983 human Jun 3725 P05412 JUN human T91 450448 SNGHItTtPtPtQFL Jun X X 2303 -MAPK8 JNK1 P45983 human PKM iso2 5315 P14618-2 PKM human T365 31886917 CIMLSGEtAKGDyPL PK X -MAPK8 JNK1 P45983 human LIMD1 8994 Q9UGP4 LIMD1 human S421 3214989 LGSVLLDsPssPRVr X X -MAPK8 JNK1 P45983 human PIN1 5300 Q13526 PIN1 human S115 1873647702 sQFSDCssAkARGDL Rotamase X X -MAPK8 JNK1 P45983 human STMN2 11075 Q93045 STMN2 human S73 450173 EAPRTLAsPKKkDLs Stathmin X -MAPK8 JNK1 P45983 human NLRP3 114548 Q96P20 NLRP3 human S198 230295300 GKTKTCEsPVSPIKM FISNA X X -MAPK8 JNK1 P45983 human SRC-3 8202 Q9Y6Q9 NCOA3 human S543 454108 SLLSTLSsPGPKLDN NCOA_u2 X -MAPK8 JNK1 P45983 human JIP3 30957 Q9ESN9 Mapk8ip3 mouse T266 458341 GQSSAAAtPSTTGTK X X -MAPK8 JNK1 P45983 human AR 367 P10275 AR human S651 448414 GEASSTTsPTEETTQ X X -MAPK8 JNK1 P45983 human STAT3 6774 P40763 STAT3 human S727 448191 NtIDLPMsPrTLDSL X X 9134; 9136; 34911; 94994; 49081; 58978; 87544; 71958; 50804 -MAPK8 JNK1 P45983 human MCL1 4170 Q07820 MCL1 human S121 1172400 PAADAIMsPEEELDG X -MAPK8 JNK1 P45983 human CDT1 81620 Q9H211 CDT1 human S411 21440504 PAtPPAAsPsALkGV X -MAPK8 JNK1 P45983 human SP1 6667 P08047 SP1 human T739 448227 sEGSGtAtPSALITT X X -MAPK8 JNK1 P45983 human hnRNP K 3190 P61978 HNRNPK human S353 450147 DSAIDTWsPSEWQMA X -MAPK8 JNK1 P45983 human BIM iso2 10018 O43521-2 BCL2L11 human S44 449602 QTEPQDRsPAPMSCD X X -MAPK8 JNK1 P45983 human Bcl-xL 598 Q07817 BCL2L1 human S62 449099 PSWHLADsPAVNGAT X X -MAPK8 JNK1 P45983 human DIABLO 56616 Q9NR28 DIABLO human S6 31857552 __MAALKsWLsRsVt X X -MAPK8 JNK1 P45983 human ITCH 16396 Q8C863 Itch mouse S199 459622 kRANGNNsPSLSNGG X -MAPK8 JNK1 P45983 human OSBP2 23762 Q969R2 OSBP2 human S762 11171320 ECSKVMHssPssPsS Oxysterol_BP X -MAPK8 JNK1 P45983 human MAFB 16658 P54841 Mafb mouse T62 11555107 VSSTPLstPCssVPs X X -MAPK8 JNK1 P45983 human NRF2 4780 Q16236 NFE2L2 human S577 10292702 DEDGkPysPSEYSLQ X -MAPK8 JNK1 P45983 human eNOS 4846 P29474 NOS3 human S114 448638 RKLQGRPsPGPPAPE X X 9575 -MAPK8 JNK1 P45983 human SRC-3 8202 Q9Y6Q9 NCOA3 human T24 454110 KRKLPCDtPGQGLtC X 2979 -MAPK8 JNK1 P45983 human p21Cip1 1026 P38936 CDKN1A human S98 478193 GGRRPGTsPALLQGT X -MAPK8 JNK1 P45983 human CDC25B iso2 994 P30305-2 CDC25B human S103 9819903 GLCMDsPsPMDPHMA M-inducer_phosp X X -MAPK8 JNK1 P45983 human GLI2 2736 P10070 GLI2 human T1546 1874115100 QNSSRLTtPRNSLTL X X -MAPK8 JNK1 P45983 human STMN3 50861 Q9NZ72 STMN3 human S60 4698871 sFEVILksPSDLsPE Stathmin X -MAPK8 JNK1 P45983 human NF-E2 4778 Q16621 NFE2 human S346 18755000 DESGNSYsPEEYALQ X X -MAPK8 JNK1 P45983 human SIRT1 23411 Q96EB6 SIRT1 human S27 452898 ADREAAssPAGEPLR X X 2327 -MAPK8 JNK1 P45983 human OSBP2 23762 Q969R2 OSBP2 human S766 15721694 VMHssPssPsSDGKQ Oxysterol_BP X -MAPK8 JNK1 P45983 human BNIP3 84480 Q9ET45 Bnip3 rat T66 4698307 DsPPRSQtPQDTNRA BNIP3 X X -MAPK8 JNK1 P45983 human FOXO4 4303 P98177 FOXO4 human T451 448518 PIPKALGtPVLtPPt X X -MAPK8 JNK1 P45983 human GLE1 2733 Q53GS7 GLE1 human T102 472369 FsPAsPAtPNGTKGk X -MAPK8 JNK1 P45983 human JIP3 30957 Q9ESN9 Mapk8ip3 mouse T276 458342 TTGTKSNtPtSSVPS X X -MAPK8 JNK1 P45983 human ATF-2 11909 P16951 Atf2 mouse T51 448224 sVIVADQtPtPtRFL X 9225; 94125; 40749; 61584; 44167 -MAPK8 JNK1 P45983 human SREBP-1 6720 P36956 SREBF1 human S117 469986 YPSMPAFsPGPGIkE X X -MAPK8 JNK1 P45983 human GR 2908 P04150 NR3C1 human S226 451796 IDENCLLsPLAGEDD GCR X X 97285 -MAPK8 JNK1 P45983 human p53 7157 P04637 TP53 human T81 447540 APAPAAPtPAAPAPA X X 2676 -MAPK8 JNK1 P45983 human Bcl-2 596 P10415 BCL2 human S87 448396 AAAGPALsPVPPVVH X X -MAPK8 JNK1 P45983 human RBM17 84991 Q96I25 RBM17 human T71 470694 DDrQIVDtPPHVAAG X -MAPK8 JNK1 P45983 human SYT4 6860 Q9H2B2 SYT4 human S135 4706863 EGEKESVsPESLKSS X X -MAPK8 JNK1 P45983 human BIM 12125 O54918 Bcl2l11 mouse S65 449330 GPLAPPAsPGPFATR X 4581; 4585 -MAPK8 JNK1 P45983 human SREBP-1 iso3 6720 P36956-3 SREBF1 human T81 36533415 SPPQPAPtPLKMYPS X -MAPK8 JNK1 P45983 human SMAD2 Q1W668 SMAD2 cow S255 448796 ELsPTTLsPVNHSLD X -MAPK8 JNK1 P45983 human CDT1 81620 Q9H211 CDT1 human T29 455584 PPkLACRtPsPARPA X -MAPK8 JNK1 P45983 human Tau iso8 4137 P10636-8 MAPT human S202 447928 sGyssPGsPGtPGsR X X 39357; 30505 -MAPK8 JNK1 P45983 human Myc 4609 P01106 MYC human S86 449991 sRRsGLCsPSyVAVt Myc_N X X -MAPK8 JNK1 P45983 human MLP 17357 P28667 Marcksl1 mouse S120 454291 GGDssAssPtEEEQE MARCKS X -MAPK8 JNK1 P45983 human BIM iso2 10018 O43521-2 BCL2L11 human T56 449071 SCDKSTQtPsPPCQA X X -MAPK8 JNK1 P45983 human PSD-95 29495 P31016 Dlg4 rat S295 456936 PTsPRRYsPVAKDLL PDZ_assoc X 45737 -MAPK8 JNK1 P45983 human p21Cip1 1026 P38936 CDKN1A human S130 455618 sGEQAEGsPGGPGDs X X -MAPK8 JNK1 P45983 human SARM1 23098 Q6SZW1 SARM1 human S548 4739912 AAREMLHsPLPCTGG X X -MAPK8 JNK1 P45983 human RXRA 6256 P19793 RXRA human S260 450891 NMGLNPssPNDPVtN Hormone_recep X -MAPK8 JNK1 P45983 human p63 8626 Q9H3D4 TP63 human S51 28802100 TQtNEFLsPEVFQHI X -MAPK8 JNK1 P45983 human Doublecortin 13193 O88809 Dcx mouse S332 451363 StPKsKQsPIStPts X -MAPK8 JNK1 P45983 human EEF1A2 1917 Q05639 EEF1A2 human S205 27930804 GDNMLEPsPNMPWFK GTP_EFTU X -MAPK8 JNK1 P45983 human PXN 5829 P49023 PXN human S178 448603 PPLPGALsPLyGVPE Paxillin X X -MAPK8 JNK1 P45983 human Bcl-xL 598 Q07817 BCL2L1 human T47 448163 GTESEMEtPsAINGN X -MAPK8 JNK1 P45983 human BAD 12015 Q61337 Bad mouse T201 450485 NLGKGGStPSQ____ Bcl-2_BAD X X -MAPK8 JNK1 P45983 human NFAT1 18019 Q60591 Nfatc2 mouse S170 449624 YREPLCLsPAssGss X -MAPK8 JNK1 P45983 human AML3 860 Q13950 RUNX2 human S118 460037 AELVRTDsPNFLCSV Runt X X -MAPK8 JNK1 P45983 human NFAT1 18019 Q60591 Nfatc2 mouse S223 447847 PRtsPIMsPRTsLAE X -MAPK8 JNK1 P45983 human LMO7 iso3 361084 Q6JBI6 Lmo7 rat S1295 50307600 LAGSVKTsPGsPsPR X -MAPK8 JNK1 P45983 human HuR 1994 Q15717 ELAVL1 human S221 478357 QAQrFrFsPMGVDHM X -MAPK8 JNK1 P45983 human ARHGAP8 23779 P85298 ARHGAP8 human S455 3635677 tKPtLPPsPLMAARR X X -MAPK8 JNK1 P45983 human BNIP3 84480 Q9ET45 Bnip3 rat S60 17548869 SKSSHCDsPPRSQtP BNIP3 X X -MAPK8 JNK1 P45983 human BIM 64547 O88498 Bcl2l11 rat S65 449330 GPLAPPAsPGPFATR X X 4581; 4585 -MAPK8 JNK1 P45983 human Bcl-2 596 P10415 BCL2 human S70 448395 RDPVARtsPLQtPAA X X 2834; 2827 -MAPK8 JNK1 P45983 human SRC-3 8202 Q9Y6Q9 NCOA3 human S867 454107 sPVsVGssPPVKNIS X -MAPK8 JNK1 P45983 human TWIST1 7291 Q15672 TWIST1 human S68 18905000 GGGDEPGsPAQGkRG X X -MAPK8 JNK1 P45983 human PPM1J 71887 Q149T7 Ppm1j mouse S92 2846507 HAGRAVQsPPDTGRR X X -MAPK8 JNK1 P45983 human NFAT3 4776 Q14934 NFATC4 human S213 953804 ASRFGLGsPLPsPRA X -MAPK8 JNK1 P45983 human DIABLO 56616 Q9NR28 DIABLO human S9 31857555 AALKsWLsRsVtSFF Smac_DIABLO X X -MAPK8 JNK1 P45983 human ELF4 2000 Q99607 ELF4 human S641 463812 SGSLLTRsPtPAPFs X X -MAPK8 JNK1 P45983 human Jun 3725 P05412 JUN human S73 447943 VGLLkLAsPELERLI Jun X X 9164; 3270; 8752; 12714; 77955 -MAPK8 JNK1 P45983 human SREBP-1 iso3 6720 P36956-3 SREBF1 human S93 469986 YPSMPAFsPGPGIKE X -MAPK8 JNK1 P45983 human CDC25B iso2 994 P30305-2 CDC25B human S101 9819902 DAGLCMDsPsPMDPH M-inducer_phosp X X -MAPK8 JNK1 P45983 human Jun 16476 P05627 Jun mouse S63 447686 kNsDLLtsPDVGLLK Jun X X 5464; 9261; 2361; 97721; 91952 -MAPK8 JNK1 P45983 human MST1 6789 Q13043 STK4 human S82 12057400 SIMQQCDsPHVVKYY Pkinase X X -MAPK8 JNK1 P45983 human STMN1 16765 P54227 Stmn1 mouse S38 448556 sVPdFPLsPPKKKDL Stathmin X X 3426; 4191 -MAPK8 JNK1 P45983 human STMN2 84510 P21818 Stmn2 rat S73 450173 EAPRTLAsPKKkDLs Stathmin X -MAPK8 JNK1 P45983 human DGCR8 54487 Q8WYQ5 DGCR8 human S153 34490414 AECGLLLsPVSGDVH X X -MAPK8 JNK1 P45983 human ABRA 286965 Q8K4K7 Abra rat T62 1255792402 ATQDLPHtPKEPGPR X X -MAPK8 JNK1 P45983 human p53 7157 P04637 TP53 human S20 447529 PLsQEtFsDLWkLLP P53_TAD X X 9287 -MAPK8 JNK1 P45983 human 4E-T 56478 Q9NRA8 EIF4ENIF1 human S587 454357 yLrPrIPsPIGFtPG EIF4E-T X X -MAPK8 JNK1 P45983 human Bcl-2 12043 P10417 Bcl2 mouse S70 448395 RDMAARtsPLRPLVA X X -MAPK8 JNK1 P45983 human NFAT1 18019 Q60591 Nfatc2 mouse T116 455763 PsPRIEItPSHELMQ X X -MAPK8 JNK1 P45983 human SCYE1 9255 Q12904 AIMP1 human S140 12440055 KKEKkQQsIAGsADS X X -MAPK8 JNK1 P45983 human Raptor 57521 Q8N122 RPTOR human S863 453732 LtQsAPAsPtNkGVH X X -MAPK8 JNK1 P45983 human NRF2 4780 Q16236 NFE2L2 human S215 10292704 VETTMVPsPEAKLTE X -MAPK8 JNK1 P45983 human Tau iso8 4137 P10636-8 MAPT human T181 447932 ktPPAPktPPssGEP X 12885; 66224; 62672 -MAPK8 JNK1 P45983 human HES1 29577 Q04666 Hes1 rat S263 23298200 SVGPNAVsPSSGSSL X X -MAPK8 JNK1 P45983 human LMO7 iso3 361084 Q6JBI6 Lmo7 rat S1305 3207705 sPsPRSHsPSMSQSG X -MAPK8 JNK1 P45983 human MARCKS 4082 P29966 MARCKS human S46 454165 VKVNGDAsPAAAEsG MARCKS X -MAPK8 JNK1 P45983 human Jun 3725 P05412 JUN human S63 447686 kNsDLLtsPDVGLLk Jun X X 5464; 9261; 2361; 97721; 91952 -MAPK8 JNK1 P45983 human ATF-2 11909 P16951 Atf2 mouse T53 448225 IVADQtPtPtRFLKN X 9225; 9221; 5112; 94125; 13850; 40749; 15411; 24329; 61584; 27934; 92109; 20534; 35858 -MAPK8 JNK1 P45983 human SIRT6 51548 Q8N6T7 SIRT6 human S10 23144710 VNYAAGLsPYADKGk X X -MAPK8 JNK1 P45983 human MCL1 4170 Q07820 MCL1 human T163 455375 tDGsLPstPPPAEEE X 4579; 14765 -MAPK8 JNK1 P45983 human Bcl-2 596 P10415 BCL2 human T69 448398 SRDPVARtsPLQtPA X -MAPK8 JNK1 P45983 human CDT1 81620 Q9H211 CDT1 human S491 21440505 GSCCTIMsPGEMEKH CDT1_C X -MAPK8 JNK1 P45983 human SHC1 20416 P98083 Shc1 mouse S36 448508 TPPEELPsPSASSLG X X -MAPK8 JNK1 P45983 human OSBP2 23762 Q969R2 OSBP2 human S768 15721697 HssPssPsSDGKQKT Oxysterol_BP X -MAPK8 JNK1 P45983 human BMF 90427 Q96LC9 BMF human S74 11267001 DKATQTLsPAsPSQG BMF X -MAPK8 JNK1 P45983 human SND1 27044 Q7KZF4 SND1 human T103 18015998 CFtIENktPQGrEyG SNase X X -MAPK8 JNK1 P45983 human GAP43 14432 P06837 Gap43 mouse S96 449105 tDAAPAtsPkAEEPs Neuromodulin X -MAPK8 JNK1 P45983 human Myc 4609 P01106 MYC human S77 448586 LLPtPPLsPsRRsGL Myc_N X X 13748 -MAPK8 JNK1 P45983 human NEIL1 79661 Q96FI4 NEIL1 human S61 57829900 KELRLILsPLPGAQP Fapy_DNA_glyco X -MAPK8 JNK1 P45983 human CDK4 1019 P11802 CDK4 human T172 448476 YSYQMALtPVVVTLW Pkinase X -MAPK8 JNK1 P45983 human STMN1 16765 P54227 Stmn1 mouse S25 448555 QAFELILsPRskEsV Stathmin X X -MAPK8 JNK1 P45983 human CTNNB1 1499 P35222 CTNNB1 human S33 447487 QQQsyLDsGIHsGAT X X 9561; 2009; 4270; 13537; 41334; 60180 -MAPK8 JNK1 P45983 human Raptor 57521 Q8N122 RPTOR human T706 11315002 ttEGGsLtPVRDsPC X X -MAPK8 JNK1 P45983 human BIM 12125 O54918 Bcl2l11 mouse S100 449602 FSFDTDRsPAPMsCD X -MAPK8 JNK1 P45983 human GNMT 27232 Q14749 GNMT human S10 460706 DSVYRtRsLGVAAEG X -MAPK8 JNK1 P45983 human PPM1J 71887 Q149T7 Ppm1j mouse T202 2846508 PPLCLPStPGtPGAP X X -MAPK8 JNK1 P45983 human NFAT2 4772 O95644 NFATC1 human S172 465577 YRDPsCLsPASSLSS X -MAPK8 JNK1 P45983 human 4E-T 56478 Q9NRA8 EIF4ENIF1 human S374 7322864 GLEQAILsPGQNsGN EIF4E-T X X -MAPK8 JNK1 P45983 human SIRT1 23411 Q96EB6 SIRT1 human T530 6006905 YLSELPPtPLHVsED X X -MAPK8 JNK1 P45983 human JunB 3726 P17275 JUNB human T104 1814000 GVITTtPtPPGQyFy Jun X 8053 -MAPK8 JNK1 P45983 human Oct4 18999 P20263 Pou5f1 mouse S347 25236701 VPVtALGsPMHSN__ X -MAPK8 JNK1 P45983 human CTNNB1 12387 Q02248 Ctnnb1 mouse S605 3545003 LFVQLLYsPIENIQR Arm X -MAPK8 JNK1 P45983 human MLP 17357 P28667 Marcksl1 mouse T148 454299 QEGKAAAtPEsQEPQ MARCKS X -MAPK8 JNK1 P45983 human RARA 5914 P10276 RARA human T181 455328 CSESYTLtPEVGELI X X -MAPK8 JNK1 P45983 human MAP2 25595 P15146 Map2 rat T1622 450181 YSSRtPGtPGtPSyP X 4544 -MAPK8 JNK1 P45983 human MAP2 25595 P15146 Map2 rat T1619 4704347 PPsYSSRtPGtPGtP X -MAPK8 JNK1 P45983 human OSBP2 23762 Q969R2 OSBP2 human S763 31727226 CSKVMHssPssPsSD Oxysterol_BP X -MAPK8 JNK1 P45983 human IRS1 3667 P35568 IRS1 human S312 447558 tEsItAtsPAsMVGG X 2381 -MAPK8 JNK1 P45983 human TAB1 10454 Q15750 TAB1 human S438 456224 tPTLTNQsPTLtLQS X X -MAPK8 JNK1 P45983 human JIP1 9479 Q9UQF2 MAPK8IP1 human T103 449924 LIDAtGDtPGAEDDE X X -MAPK8 JNK1 P45983 human CTNNB1 1499 P35222 CTNNB1 human T41 447583 GIHsGATtTAPsLsG X X 9561; 9565; 4270; 13537; 41334; 60180 -MAPK8 JNK1 P45983 human LIMD1 8994 Q9UGP4 LIMD1 human S424 3214995 VLLDsPssPRVrLPC X X -MAPK8 JNK1 P45983 human mGluR5 24418 P31424 Grm5 rat T1087 1876620108 ATPGPPGtPICSSYL X X -MAPK8 JNK1 P45983 human IP3R1 16438 P11881 Itpr1 mouse S1755 450682 RPSGRREsLtsFGNG X 3760; 8548 -MAPK8 JNK1 P45983 human GLE1 2733 Q53GS7 GLE1 human S93 31084897 PKsPDAssAFsPAsP X -MAPK8 JNK1 P45983 human 14-3-3 zeta 7534 P63104 YWHAZ human S184 449855 FyYEILNsPEKACSL 14-3-3 X X -MAPK8 JNK1 P45983 human FOXO4 4303 P98177 FOXO4 human T455 448570 ALGtPVLtPPtEAAS X X -MAPK8 JNK1 P45983 human NEIL1 79661 Q96FI4 NEIL1 human S306 34504097 KSKATQLsPEDRVED X -MAPK8 JNK1 P45983 human 14-3-3 beta 7529 P31946 YWHAB human S186 449845 FyYEILNsPEKACSL 14-3-3 X -MAPK8 JNK1 P45983 human FOXO4 4303 P98177 FOXO4 human T227 15798100 PAPPEGAtPTsPVGH X X -MAPK8 JNK1 P45983 human FOXO4 4303 P98177 FOXO4 human S230 471960 PEGAtPTsPVGHFAK X -MAPK8 JNK1 P45983 human GLE1 2733 Q53GS7 GLE1 human S92 50831365 VPKsPDAssAFsPAs X -MAPK8 JNK1 P45983 human RARA 5914 P10276 RARA human S445 455329 APPPGSCsPSLSPSS X X -MAPK8 JNK1 P45983 human PPM1J 71887 Q149T7 Ppm1j mouse T205 2846509 CLPStPGtPGAPSPS X X -MAPK8 JNK1 P45983 human NFAT1 18019 Q60591 Nfatc2 mouse S110 1861201 PAGAsGPsPRIEItP X -MAPK8 JNK1 P45983 human NFAT1 18019 Q60591 Nfatc2 mouse S219 447846 AHYsPRtsPIMsPRT X -MAPK8 JNK1 P45983 human MAP2 25595 P15146 Map2 rat T1625 450182 RtPGtPGtPSyPRTP X 4544 -MAPK8 JNK1 P45983 human CDT1 81620 Q9H211 CDT1 human T406 21440503 LPAtPPAtPPAAsPs X -MAPK8 JNK1 P45983 human BIM 12125 O54918 Bcl2l11 mouse T112 449071 sCDKStQtPsPPCQA X -MAPK8 JNK1 P45983 human LMO7 iso3 361084 Q6JBI6 Lmo7 rat S727 4687599 SLREVSRsPDQFSDM X -MAPK8 JNK1 P45983 human hnRNP K 3190 P61978 HNRNPK human S216 450148 ILDLIsEsPIkGRAQ X -MAPK8 JNK1 P45983 human GLE1 2733 Q53GS7 GLE1 human S88 12667856 QPSFVPKsPDAssAF X -MAPK8 JNK1 P45983 human IRF3 3661 Q14653 IRF3 human S173 6370303 PCPQPLRsPsLDNPt X X -MAPK8 JNK1 P45983 human K8 3856 P05787 KRT8 human S432 448540 sAyGGLtsPGLsysL X -MAPK8 JNK1 P45983 human FOXO3A 56484 Q9WVH4 Foxo3 mouse S573 20799900 SAkHQQQsPASQSMQ X -MAPK8 JNK1 P45983 human p21Cip1 1026 P38936 CDKN1A human T57 451222 NFDFVtEtPLEGDFA CDI X -MAPK8 JNK1 P45983 human ITCH 16396 Q8C863 Itch mouse T222 459624 PSRPPPPtPRRPASV X -MAPK8 JNK1 P45983 human NFAT1 18019 Q60591 Nfatc2 mouse T332 451863 WKtsPDPtPVSTAPS X -MAPK8 JNK1 P45983 human ITCH 16396 Q8C863 Itch mouse S232 459623 RPASVNGsPSTNSDS X -MAPK8 JNK1 P45983 human YAP1 iso3 10413 P46937-3 YAP1 human T362 23939103 SSySVPRtPDDFLNS X X -MAPK8 JNK1 P45983 human DCP1A 55802 Q9NPI6 DCP1A human S315 3213294 PtytIPLsPVLsPtL X X -MAPK8 JNK1 P45983 human SRC-3 8202 Q9Y6Q9 NCOA3 human S505 454109 SPVAGVHsPMAsSGN NCOA_u2 X -MAPK8 JNK1 P45983 human Jun 3725 P05412 JUN human T93 450449 GHItTtPtPtQFLCP Jun X X 2993 -MAPK8 JNK1 P45983 human APLP2 334 Q06481 APLP2 human T736 451599 VEVDPMLtPEERHLN APP_amyloid X X -MAPK8 JNK1 P45983 human STAT1 20846 P42225 Stat1 mouse S727 447753 tDNLLPMsPEEFDEM STAT1_TAZ2bind X 9177; 8826; 62390 -MAPK8 JNK1 P45983 human IRS2 384783 P81122 Irs2 mouse S488 1308920 GSAsASGsPSDPGFM X -MAPK8 JNK1 P45983 human NF-E2 4778 Q16621 NFE2 human S157 11489902 LNYSDAEsLELEGTE X X -MARK3 MARK3 P27448 human MEF2C 4208 Q06413 MEF2C human S222 474086 GYGNPRNsPGLLVsP X -MARK3 MARK3 P27448 human PPP1R2 5504 P41236 PPP1R2 human S72 3190237 LMKIDEPstPyHSMM IPP-2 X -MARK3 MARK3 P27448 human CDC25C 995 P30307 CDC25C human S216 448418 sGLyRsPsMPENLNR M-inducer_phosp X 9528; 4901; 30790 -MARK3 MARK3 P27448 human TNK1 8711 Q13470 TNK1 human S502 483166 RMKGIsRsLEsVLsL X -MARK3 MARK3 P27448 human FEZ1 9638 Q99689 FEZ1 human S58 454522 SEIISFKsMEDLVNE FEZ X X -MARK3 MARK3 P27448 human ARHGEF2 9181 Q92974 ARHGEF2 human S151 1211018 LsLAksVsttNIAGH X X -MARK3 MARK3 P27448 human TORC2 74343 Q3U182 Crtc2 mouse S275 3174300 PAMNTGGsLPDLTNL TORC_M X -Tek TIE2 Q02858 mouse TIE2 21687 Q02858 Tek mouse Y1100 450256 MLEERKTyVNTTLyE X X -AKT2 Akt2 P31751 human SFRS5 29667 Q09167 Srsf5 rat S86 3685800 GRGRGRYsDRFSSRR X -AKT2 Akt2 P31751 human ATP7A 538 Q04656 ATP7A human S1424 50479822 SYELPARsQIGQKsP X X -AKT2 Akt2 P31751 human plakophilin 1 5317 Q13835 PKP1 human S63 18261122 ssQsstLsHsNRGsM X X -AKT2 Akt2 P31751 human GAB2 14389 Q9Z1S8 Gab2 mouse T388 448383 ATIPRRNtLPAMDNS X -AKT2 Akt2 P31751 human IRF3 3661 Q14653 IRF3 human T180 28095000 sPsLDNPtPFPNLGP X -AKT2 Akt2 P31751 human CD34 12490 Q64314 Cd34 mouse S343 4733136 yssGPGAsPETQGkA CD34_antigen X -AKT2 Akt2 P31751 human QIK 235344 Q8CFH6 Sik2 mouse S358 487501 DGRQRRPstIAEQTV X -AKT2 Akt2 P31751 human EGFR 1956 P00533 EGFR human S229 18944906 rCrGKSPsDCCHNQC Furin-like X -AKT2 Akt2 P31751 human plakophilin 1 5317 Q13835 PKP1 human T179 27717307 LGsKGQKttQNRysF X X -AKT2 Akt2 P31751 human Ezrin 7430 P15311 EZR human T567 448104 QGRDkyKtLRQIRQG ERM_C X X 3141; 3726; 32600 -AKT2 Akt2 P31751 human CBY1 25776 Q9Y3M2 CBY1 human S20 2850009 TPPRKsAsLSNLHsL Chibby X -AKT2 Akt2 P31751 human CLK2 12748 O35491 Clk2 mouse T343 26375903 HHSTIVstRHYRAPE Pkinase X -AKT2 Akt2 P31751 human HSF1 3297 Q00613 HSF1 human S230 448072 PkYSRQFsLEHVHGS X X -AKT2 Akt2 P31751 human BMI1 648 P35226 BMI1 human S316 6150348 ANRPRKssVNGSSAT X X -AKT2 Akt2 P31751 human ADAR 103 P55265 ADAR human T1033 1868546602 RLGERLRtMSCSDKI A_deamin X -AKT2 Akt2 P31751 human plakophilin 1 5317 Q13835 PKP1 human S191 15405309 ysFystCsGQKAIKK X X -AKT2 Akt2 P31751 human FLNC 2318 Q14315 FLNC human S2233 467899 LGRERLGsFGsItRQ Filamin X -AKT2 Akt2 P31751 human plakophilin 1 5317 Q13835 PKP1 human T180 27717309 GsKGQKttQNRysFy X X -AKT2 Akt2 P31751 human IRS2 8660 Q9Y4H2 IRS2 human S365 483509 sCRVRtAsEGDGGAA X -AKT2 Akt2 P31751 human H3 8350 P68431 H3C1 human S10 455676 tkQtArkstGGkAPr Histone X 9701; 9711; 9606; 3465; 3642; 3377; 3475; 3458; 5764; 47398; 8481; 8552; 53348; 29237; 66065; 43185; 64522; 52725 -AKT2 Akt2 P31751 human WIPF1 7456 O43516 WIPF1 human T398 14582886 TSRALPAtPQLPSrS X X -AKT2 Akt2 P31751 human plakophilin 1 5317 Q13835 PKP1 human S127 7102607 ysQMENWsRHYPRGS X X -AKT2 Akt2 P31751 human EDC3 80153 Q96F86 EDC3 human S161 1211074 sFRRRHNsWssssRH Edc3_linker X -AKT2 Akt2 P31751 human ATP7A 538 Q04656 ATP7A human S1466 4733428 ysRAsINsLLsDkRs X X -AKT2 Akt2 P31751 human plakophilin 1 5317 Q13835 PKP1 human S118 4712605 EPDNRRFssysQMEN X X -AKT2 Akt2 P31751 human BAP37 11331 Q99623 PHB2 human S91 22342307 RARPRkIssPTGSkD Band_7 X -AKT2 Akt2 P31751 human IKKA 1147 O15111 CHUK human T23 447780 EMRERLGtGGFGNVC Pkinase X X -AKT2 Akt2 P31751 human BAP37 11331 Q99623 PHB2 human S176 31828200 TERAKDFsLILDDVA Band_7 X -AKT2 Akt2 P31751 human H3 8350 P68431 H3C1 human S28 455677 ATkAArksAPATGGV Histone X 9713 -AKT2 Akt2 P31751 human RED1 104 P78563 ADARB1 human T553 31884906 LQGERLLtMSCSDKI A_deamin X -AKT2 Akt2 P31751 human plakophilin 1 5317 Q13835 PKP1 human S65 465636 QsstLsHsNRGsMyD X X -AKT2 Akt2 P31751 human MYO5A 17918 Q99104 Myo5a mouse S1650 480053 GLRKRtssIADEGty X -AKT2 Akt2 P31751 human lamin A/C 4000 P02545 LMNA human S390 452605 EEErLRLsPsPtsQR X X -AKT2 Akt2 P31751 human ATP7A 538 Q04656 ATP7A human S1463 4733422 IVNysRAsINsLLsD X X -AKT2 Akt2 P31751 human plakophilin 1 5317 Q13835 PKP1 human T171 27717301 RGtLRKGtLGsKGQK X X -AKT2 Akt2 P31751 human CAD 69719 B2RQC6 Cad mouse S1406 451249 GAGGRRLssFVTKGY MGS X -AKT2 Akt2 P31751 human CAD 69719 B2RQC6 Cad mouse S1859 451247 PPRIHRAsDPGLPAE X 12662; 67235; 70307 -AKT2 Akt2 P31751 human plakophilin 1 5317 Q13835 PKP1 human T82 15405303 ADNyNyGttsRssYy X X -AKT2 Akt2 P31751 human IRF3 3661 Q14653 IRF3 human S175 14567912 PQPLRsPsLDNPtPF X -AKT2 Akt2 P31751 human PPIF 10105 P30405 PPIF human S31 40256000 LPAARACsKGsGDPS X X -AKT2 Akt2 P31751 human plakophilin 1 5317 Q13835 PKP1 human T61 27717305 sKssQsstLsHsNRG X X -AKT2 Akt2 P31751 human GAPDH 2597 P04406 GAPDH human T237 4658322 GMAFrVPtANVsVVD Gp_dh_C X -AKT2 Akt2 P31751 human PITX2 18741 P97474 Pitx2 mouse T90 25790902 KRQRRQRtHFTSQQL Homeodomain X -AKT2 Akt2 P31751 human plakophilin 1 5317 Q13835 PKP1 human S69 23132559 LsHsNRGsMyDGLAD X X -AKT2 Akt2 P31751 human plakophilin 1 5317 Q13835 PKP1 human S174 27717303 LRKGtLGsKGQKttQ X X -AKT2 Akt2 P31751 human lamin A/C 4000 P02545 LMNA human S404 478681 RsRGRAssHssQtQG X -AKT2 Akt2 P31751 human plakophilin 1 5317 Q13835 PKP1 human S54 27717310 MTVKRQKsKssQsst X X -AKT2 Akt2 P31751 human ASK1 4217 Q99683 MAP3K5 human S83 447735 ATRGRGssVGGGSrR X X 3761 -AKT2 Akt2 P31751 human HTRA2 27429 O43464 HTRA2 human S212 477180 RVRVRLLsGDTYEAV Trypsin_2; Peptidase_M50 X X -AKT2 Akt2 P31751 human hnRNP E1 23983 P60335 Pcbp1 mouse S43 13258708 VKRIREEsGARINIs KH_1 X -AKT2 Akt2 P31751 human LBR G1N806 LBR turkey S82 14575430 RSRsRsRsRsPGRPA X -AKT2 Akt2 P31751 human plakophilin 1 5317 Q13835 PKP1 human S185 15405312 KttQNRysFystCsG X X -AKT2 Akt2 P31751 human XIAP 331 P98170 XIAP human S87 450336 VGRHRKVsPNCRFIN BIR X X -AKT2 Akt2 P31751 human plakophilin 1 5317 Q13835 PKP1 human S57 27717308 KRQKsKssQsstLsH X X -AKT2 Akt2 P31751 human IRF3 3661 Q14653 IRF3 human S14 23116256 RILPWLVsQLDLGQL IRF X -AKT2 Akt2 P31751 human CYCS 54205 P99999 CYCS human Y47 3416311 ktGQAPGysytAANk Cytochrom_C X -AKT2 Akt2 P31751 human IRS2 8660 Q9Y4H2 IRS2 human S1149 453435 GGRRRHssEtFSsTt X 2385 -AKT2 Akt2 P31751 human RENT1 5976 Q92900 UPF1 human T151 50788283 FCNGRGNtSGSHIVN UPF1_Zn_bind X -AKT2 Akt2 P31751 human p300 328572 B2RWS6 Ep300 mouse S1733 1295500 PGDSRRLsIQRCIQS X -AKT2 Akt2 P31751 human GATA6 iso2 2627 Q92908-2 GATA6 human S290 18009944 KPQKRVPsSRRLGLS X X -AKT2 Akt2 P31751 human ER-alpha 2099 P03372 ESR1 human S167 448102 GGRERLAsTNDkGSM Oest_recep X 64508; 42101 -AKT2 Akt2 P31751 human plakophilin 1 5317 Q13835 PKP1 human T166 15405306 LyCDPRGtLRKGtLG X X -AKT2 Akt2 P31751 human plakophilin 1 5317 Q13835 PKP1 human T189 15413424 NRysFystCsGQKAI X X -AKT2 Akt2 P31751 human fascin 6624 Q16658 FSCN1 human T403 15720201 GCRkVTGtLDANRSS Fascin X X -AKT2 Akt2 P31751 human MgcRacGAP 29127 Q9H0H5 RACGAP1 human T249 478691 WTRSRRktGtLQPWN X -AKT2 Akt2 P31751 human IRS2 8660 Q9Y4H2 IRS2 human S306 3217341 EFRPRsksQssGssA X X -AKT2 Akt2 P31751 human LBR G1N806 LBR turkey S80 14575427 SRRSRsRsRsRsPGR X -AKT2 Akt2 P31751 human RSK2 6197 P51812 RPS6KA3 human T115 1880515604 KVRDRVRtKMERDIL X -AKT2 Akt2 P31751 human Merlin 4771 P35240 NF2 human S10 1720901 GAIASRMsFSsLkRK X -AKT2 Akt2 P31751 human plakophilin 1 5317 Q13835 PKP1 human S188 15413421 QNRysFystCsGQKA X X -AKT2 Akt2 P31751 human plakophilin 1 5317 Q13835 PKP1 human S84 27717311 NyNyGttsRssYySK X X -AKT2 Akt2 P31751 human plakophilin 1 5317 Q13835 PKP1 human S60 27717302 KsKssQsstLsHsNR X X -AKT2 Akt2 P31751 human plakophilin 1 5317 Q13835 PKP1 human S121 465635 NRRFssysQMENWsR X X -AKT2 Akt2 P31751 human KHSRP 8570 Q92945 KHSRP human S193 473552 GLPERsVsLtGAPEs KH_1 X -AKT2 Akt2 P31751 human PIP5K1C 23396 O60331 PIP5K1C human S555 1855423 RYRRRtQssGQDGRP X -AKT2 Akt2 P31751 human MAT1A 4143 Q00266 MAT1A human T202 1874404504 VIPVRIHtIVISVQH S-AdoMet_synt_M X -AKT2 Akt2 P31751 human TMOD3 50875 Q9JHJ0 Tmod3 mouse S71 456118 FDRERLLsYLEkQAL Tropomodulin X X -AKT2 Akt2 P31751 human HSF1 3297 Q00613 HSF1 human S326 455484 ssVDtLLsPTALIDs Vert_HS_TF X -AKT2 Akt2 P31751 human CTNNB1 1499 P35222 CTNNB1 human S552 472273 QDtQRRtsMGGtQQQ X X 9566; 5651 -AKT2 Akt2 P31751 human ANKRD2 26287 Q9GZV1 ANKRD2 human S99 480101 QERVRKTsLDLRREI X X -AKT2 Akt2 P31751 human IRS2 8660 Q9Y4H2 IRS2 human S577 483923 GLRKRtysLttPARQ X X -AKT2 Akt2 P31751 human IRF3 3661 Q14653 IRF3 human T207 1876336802 EEWEFEVtAFYRGRQ IRF-3 X -AKT2 Akt2 P31751 human HK2 15277 O08528 Hk2 mouse T473 28704601 QHRARQKtLESLKLS Hexokinase_1 X -AKT2 Akt2 P31751 human CDP138 9847 Q86YS7 C2CD5 human S197 21398500 EARQRLIsLMsGELQ X X -AKT2 Akt2 P31751 human SH3RF1 57630 Q7Z6J0 SH3RF1 human S304 482847 KNTKKRHsFtsLtMA X -AKT2 Akt2 P31751 human p300 328572 B2RWS6 Ep300 mouse S1833 447591 MLRRRMAsMQRTGVA X -AKT2 Akt2 P31751 human PDHK1 5163 Q15118 PDK1 human T346 13831355 APRPRVEtsRAVPLA HATPase_c X X -AKT2 Akt2 P31751 human plakophilin 1 5317 Q13835 PKP1 human S59 27717304 QKsKssQsstLsHsN X X -AKT2 Akt2 P31751 human H3 8350 P68431 H3C1 human T45 455679 PHryrPGtVALrEIR Histone X X -AKT2 Akt2 P31751 human plakophilin 1 5317 Q13835 PKP1 human S119 4712610 PDNRRFssysQMENW X X -AKT2 Akt2 P31751 human EPRS 2058 P07814 EPRS1 human S999 9720900 NQGGGLsssGAGEGQ X -AKT2 Akt2 P31751 human WIPF1 7456 O43516 WIPF1 human S154 23073655 PGrFPVPsPGHRSGP X -AKT2 Akt2 P31751 human plakophilin 1 5317 Q13835 PKP1 human S56 27717306 VKRQKsKssQsstLs X X -AKT2 Akt2 P31751 human MAT1A 4143 Q00266 MAT1A human S180 1874404502 LPWLRPDsKTQVTVQ S-AdoMet_synt_M X -AKT2 Akt2 P31751 human GAB2 14389 Q9Z1S8 Gab2 mouse S211 4825112 TENARSAsFSQGTRQ X -HIPK3 HIPK3 Q9H422 human DAXX 1616 Q9UER7 DAXX human S668 448623 KKICtLPsPPsPLAs X -PRKCB PKCB P05771 human ANXA1 301 P04083 ANXA1 human S28 452053 yVQtVksskGGPGsA X -PRKCB PKCB P05771 human CARD11 416476 Q5F3W0 RCJMB04_5k17 chicken S668 457639 LERPFRPsVTSVGRI X X 5189 -PRKCB PKCB P05771 human Tau iso8 4137 P10636-8 MAPT human S352 487459 DFKDrVQskIGsLDN Tubulin-binding X -PRKCB PKCB P05771 human ITGB2 3689 P05107 ITGB2 human S745 448532 FEkEKLksQWNNDNP Integrin_b_cyt X -PRKCB PKCB P05771 human PKCB iso2 5579 P05771-2 PRKCB human S660 1869073011 QsEFEGFsFVNsEFL Pkinase_C X 9371 -PRKCB PKCB P05771 human CACNA1C 100101555 P15381 CACB rabbit S1928 455278 ASLGRRAsFHLECLK CAC1F_C X X -PRKCB PKCB P05771 human SHP-2 5781 Q06124 PTPN11 human S591 469623 GLMQQQksFR_____ X -PRKCB PKCB P05771 human MYH9 4627 P35579 MYH9 human S1916 451181 AMNREVssLkNkLRr Myosin_tail_1 X -PRKCB PKCB P05771 human ANXA2 302 P07355 ANXA2 human S26 450879 tPPsAyGsVkAytNF X -PRKCB PKCB P05771 human CARD11 108723 Q8CIS0 Card11 mouse S564 457637 QPHRSRSsIMsItAE X -PRKCB PKCB P05771 human LIN28B 389421 Q6ZN17 LIN28B human S243 1870790709 EQSKkGPsVQKRKKT X -PRKCB PKCB P05771 human ORAI1 84876 Q96D31 ORAI1 human S27 469411 GGSTTsGsRRsRRRs X X -PRKCB PKCB P05771 human Kv3.4 3749 Q03721 KCNC4 human S9 451076 ISSVCVssYRGRKsG Potassium_chann X -PRKCB PKCB P05771 human ATP1A1 24211 P06685 Atp1a1 rat S16 449086 KyEPAAVsEHGDkks X 4020 -PRKCB PKCB P05771 human ITGB2 3689 P05107 ITGB2 human T758 448533 NPLFksAtttVMNPk Integrin_b_cyt X -PRKCB PKCB P05771 human PIK3CG 5294 P48736 PIK3CG human S582 28702402 LWHFRYEsLKHPKAY PI3Ka X X -PRKCB PKCB P05771 human Akt1 207 P31749 AKT1 human S473 447855 RPHFPQFsysAsGtA Pkinase_C X 9271; 3787; 4060; 4051; 5102; 4058; 2336; 2337; 4075; 4070; 5012; 4071; 92982; 5315; 9563; 9018; 12694; 52240; 11962; 15116; 88106; 26580; 68035; 31957; 23430; 20235 -PRKCB PKCB P05771 human p47phox 653361 P14598 NCF1 human S320 451726 QRsRKRLsQDAYRRN NECFESHC X -PRKCB PKCB P05771 human IBTK 25998 Q9P2D0 IBTK human S1200 21358401 ASSLHsVsSksFRDF X X -PRKCB PKCB P05771 human EphA2 1969 P29317 EPHA2 human S892 3189622 ADFDPRVsIRLPsts X X -PRKCB PKCB P05771 human Kv3.4 3749 Q03721 KCNC4 human S21 451078 KsGNKPPsKTCLKEE Potassium_chann X -PRKCB PKCB P05771 human AMPKA1 5562 Q13131 PRKAA1 human S496 450431 AtPQRsGsVsNyRSC AdenylateSensor X 4185; 4184; 2537 -PRKCB PKCB P05771 human AID 11628 Q9WVE0 Aicda mouse S3 20660600 _____MDsLLMKQKK X -PRKCB PKCB P05771 human CACNA1C 100101555 P15381 CACB rabbit S533 453091 RIsKSKFsRYWRRWN X -PRKCB PKCB P05771 human SHP-2 5781 Q06124 PTPN11 human S576 469622 CAEMREDsARVyENV X -PRKCB PKCB P05771 human NOX5 iso4 79400 Q96PH1-4 NOX5 human T494 472625 KRLsRSVtMRKsQRS FAD_binding_8 X -PRKCB PKCB P05771 human EPB41 iso4 2035 P11171-4 EPB41 human S312 455112 QAQTRQAsALIDRPA FA X -PRKCB PKCB P05771 human STMN1 3925 P16949 STMN1 human S25 448555 QAFELILsPrskEsV Stathmin X -PRKCB PKCB P05771 human TFEB 21425 Q9R210 Tfeb mouse S462 4785132 PEASKAssRRssFsM DUF3371 X -PRKCB PKCB P05771 human IRS1 16367 P35569 Irs1 mouse S318 451399 MVGGKPGsFRVRASs X 5610 -PRKCB PKCB P05771 human TYR 7299 P14679 TYR human S527 486440 DYHsLYQsHL_____ X X -PRKCB PKCB P05771 human Tau iso8 4137 P10636-8 MAPT human S324 449328 kVtskCGsLGNIHHk Tubulin-binding X -PRKCB PKCB P05771 human GSK3A 606496 Q2NL51 Gsk3a mouse S21 448584 sGRARtssFAEPGGG X 9337; 9316; 9331; 9327; 8452; 8566 -PRKCB PKCB P05771 human MARCKS 4082 P29966 MARCKS human S163 447787 KRFsFkKsFkLsGFs MARCKS X 2741; 11992 -PRKCB PKCB P05771 human RBCK1 Q62921 Rbck1 rat T161 2103604 DLGFKDLtLQPRGPL X -PRKCB PKCB P05771 human CHAT iso3 1103 P28329-3 CHAT human S440 449057 VPTYESAsIRRFQEG Carn_acyltransf X -PRKCB PKCB P05771 human STMN1 3925 P16949 STMN1 human S38 448556 sVPEFPLsPPkKkDL Stathmin X 3426; 4191 -PRKCB PKCB P05771 human GSK3B 56637 Q9WV60 Gsk3b mouse S9 449111 SGRPRttsFAEsCKP X 9336; 9331; 9327; 9323; 9322; 9325; 5558; 8566; 79774; 8466; 25462; 14026; 14332; 14310; 14630 -PRKCB PKCB P05771 human MSX2 4488 P35548 MSX2 human T135 25554905 HMsPTTCtLRKHKtN X X -PRKCB PKCB P05771 human RBCK1 Q62921 Rbck1 rat S270 2103606 HVQLEQRsLVLNtEP X -PRKCB PKCB P05771 human CHAT iso3 1103 P28329-3 CHAT human S347 454036 LKHVTQssRKLIRAD Carn_acyltransf X -PRKCB PKCB P05771 human CHAT iso3 1103 P28329-3 CHAT human T255 454038 TVLVKDStNRDSLDM Carn_acyltransf X -PRKCB PKCB P05771 human CARD11 108723 Q8CIS0 Card11 mouse S657 457639 LERPFRPsVTSGGHV X X 5189 -PRKCB PKCB P05771 human TYR 7299 P14679 TYR human S523 486439 MEKEDYHsLYQsHL_ X X -PRKCB PKCB P05771 human mGluR5 24418 P31424 Grm5 rat S839 455778 VRSAFTTstVVRMHV X -PRKCB PKCB P05771 human CARD11 108723 Q8CIS0 Card11 mouse S649 457638 NLMLRKFsLERPFRP X X -PRKCB PKCB P05771 human Tau iso8 4137 P10636-8 MAPT human S293 449327 NVQskCGsKDNIkHV Tubulin-binding X -PRKCB PKCB P05771 human p47phox 653361 P14598 NCF1 human S304 449406 GAPPRRssIRNAHsI NECFESHC X -PRKCB PKCB P05771 human TFEB 21425 Q9R210 Tfeb mouse S466 4785142 KAssRRssFsMEEGD DUF3371 X -PRKCB PKCB P05771 human SHC1 6464 P29353 SHC1 human T206 58109400 VPGAkGAtRRRKPCs PID X -PRKCB PKCB P05771 human GSK3A 2931 P49840 GSK3A human S21 448584 sGrARtssFAEPGGG X 9337; 9316; 9331; 5090; 9327; 8452; 8566 -PRKCB PKCB P05771 human IBTK 25998 Q9P2D0 IBTK human S1203 15483703 LHsVsSksFRDFLLE X X -PRKCB PKCB P05771 human TRPM8 79054 Q7Z2W7 TRPM8 human S1040 34360655 CKEKNMEssVCCFKN X -PRKCB PKCB P05771 human MARCKS 4082 P29966 MARCKS human S159 447786 kkKKKRFsFkKsFkL MARCKS X 2741; 11992 -PRKCB PKCB P05771 human ATP1A1 24211 P06685 Atp1a1 rat S23 449087 sEHGDkkskkAKKER X 4006 -PRKCB PKCB P05771 human NOX5 iso4 79400 Q96PH1-4 NOX5 human S498 472626 RSVtMRKsQRSsKGS FAD_binding_8 X -PRKCB PKCB P05771 human HNF4 alpha 25735 P22449 Hnf4a rat S87 478421 CKGFFRRsVRKNHMY zf-C4 X -PRKCB PKCB P05771 human GRN 2896 P28799 GRN human S81 41198100 IFTVSGTsSCCPFPE Granulin X -PRKCB PKCB P05771 human SHC1 6464 P29353 SHC1 human S213 58109401 tRRRKPCsRPLSSIL PID X -PRKCB PKCB P05771 human RASGRP3 421460 Q5ZID9 RASGRP3 chicken T133 454419 YDWMRRVtQRKKISK X -PRKCB PKCB P05771 human Tau iso8 4137 P10636-8 MAPT human S258 487453 PDLkNVKskIGstEN Tubulin-binding X -PRKCB PKCB P05771 human Kv3.4 3749 Q03721 KCNC4 human S8 451075 MISSVCVssYRGRKs Potassium_chann X -PRKCB PKCB P05771 human ATF-2 1386 P15336 ATF2 human S121 6406001 LAtPIIRsKIEEPSV X -PRKCB PKCB P05771 human GSK3B 2932 P49841 GSK3B human S9 449111 SGRPRttsFAEsCkP X 9336; 9331; 9327; 9323; 9322; 9325; 5558; 8566; 79774; 8466; 25462; 14026; 14332; 14310; 14630 -PRKCB PKCB P05771 human RBCK1 Q62921 Rbck1 rat S285 2103608 AECPVCYsVLAPGEA zf-RING_UBOX X -PRKCB PKCB P05771 human SNAP-25 25012 P60881 Snap25 rat S187 448668 RIMEkADsNkTRIDE X -PRKCB PKCB P05771 human TFEB 21425 Q9R210 Tfeb mouse S461 4785127 sPEASKAssRRssFs DUF3371 X -PRKCB PKCB P05771 human occludin 100506658 Q16625 OCLN human S490 6094300 RLKQVkGsADYKSKK Occludin_ELL X X -PRKCB PKCB P05771 human P70S6KB 6199 Q9UBS0 RPS6KB2 human S473 450071 PPSGTKKsKRGRGRP X X -PRKCB PKCB P05771 human ORAI1 84876 Q96D31 ORAI1 human S30 14932000 TTsGsRRsRRRsGDG X X -PRKCB PKCB P05771 human HMGA1 117062 Q8K585 Hmga1 rat S44 479856 PGTALVGsQKEPSEV X -PRKCB PKCB P05771 human MSX2 4488 P35548 MSX2 human T141 25554904 CtLRKHKtNRKPRTP X X -PRKCB PKCB P05771 human CFLAR iso2 8837 O15519-2 CFLAR human S193 7590803 LQAAIQKsLKDPSNN X -PRKCB PKCB P05771 human RBCK1 Q62921 Rbck1 rat T275 2103607 QRsLVLNtEPAECPV X -PRKCB PKCB P05771 human RBCK1 Q62921 Rbck1 rat S137 2103603 LLSARNTsLNPQELQ X -PRKCB PKCB P05771 human C5aR 728 P21730 C5AR1 human S334 448819 sVVREsKsFTRsTVD X X -PRKCB PKCB P05771 human Kv3.4 3749 Q03721 KCNC4 human S15 451077 ssYRGRKsGNKPPsK Potassium_chann X -PRKCB PKCB P05771 human Claudin-1 9076 O95832 CLDN1 human T191 1869121000 CSCPRkTtsYPtPRP X -PRKCB PKCB P05771 human KLHL3 26249 Q9UH77 KLHL3 human S433 36440206 PMNTRRSsVGVGVVE Kelch_1 X X -PRKCB PKCB P05771 human IRS1 3667 P35568 IRS1 human S323 451399 MVGGKPGsFRVRAss X 5610 -PRKCB PKCB P05771 human CACNA1C 100101555 P15381 CACB rabbit S528 486358 ARLAHRIsKSKFsRY X -PRKCB PKCB P05771 human SHC1 6464 P29353 SHC1 human S139 448791 EEWTRHGsFVNkPtR X X -PRKCB PKCB P05771 human p47phox 653361 P14598 NCF1 human S315 451725 AHsIHQRsRKRLsQD NECFESHC X -PRKCB PKCB P05771 human CFLAR 8837 O15519 CFLAR human S193 7590803 LQAAIQksLkDPSNN X -PRKCB PKCB P05771 human TRPM8 79054 Q7Z2W7 TRPM8 human S1041 34360658 KEKNMEssVCCFKNE X -PRKCB PKCB P05771 human p47phox 653361 P14598 NCF1 human S328 449404 QDAYRRNsVRFLQQR NECFESHC X -PRKCB PKCB P05771 human CHAT iso3 1103 P28329-3 CHAT human S476 454037 HKAAVPAsEKLLLLK Carn_acyltransf X -PRKCB PKCB P05771 human TFEB 21425 Q9R210 Tfeb mouse S468 4785147 ssRRssFsMEEGDVL DUF3371 X -PRKCB PKCB P05771 human CHAT iso3 1103 P28329-3 CHAT human S346 454035 LLKHVTQssRKLIRA Carn_acyltransf X -PRKCB PKCB P05771 human NFAT90 3609 Q12906 ILF3 human S647 3496801 rGrGRGGsIRGRGRG X X -PRKCB PKCB P05771 human H3 8350 P68431 H3C1 human T6 13321500 __ArtkQtArkstGG Histone X X -PRKCB PKCB P05771 human AID 11628 Q9WVE0 Aicda mouse T140 6835300 GVQIGIMtFKDYFYC APOBEC2 X -PRKCB PKCB P05771 human FCER1G 2207 P30273 FCER1G human S69 13310016 DGVytGLstRNQEty ITAM X -PRKCB PKCB P05771 human IRS1 3667 P35568 IRS1 human S441 1990800 SPCDFRSsFRsVtPD X -PRKCB PKCB P05771 human GLUT1 24778 P11167 Slc2a1 rat S226 10827359 NEENRAKsVLKKLRG Sugar_tr X -PRKCB PKCB P05771 human ACSL4 2182 O60488 ACSL4 human T328 1876129100 LAHVLELtAEISCFT AMP-binding X X -PRKCB PKCB P05771 human CACNA1C 100101555 P15381 CACB rabbit S1674 480102 QGLVGKPsQRNALSL X X -PRKCB PKCB P05771 human RBCK1 Q62921 Rbck1 rat T207 2103605 CTFINKPtRPGCEMC X -PRKCB PKCB P05771 human occludin 18260 Q61146 Ocln mouse S489 6094300 RLKQVKGsADYKSKR Occludin_ELL X -PRKCB PKCB P05771 human HMGA1 117062 Q8K585 Hmga1 rat S64 3136103 PRGRPKGsKNKGTAK X -PRKCB PKCB P05771 human Akt1 207 P31749 AKT1 human T308 447856 kDGAtMKtFCGtPEy Pkinase X 5106; 2965; 9275; 4056; 5056; 13842; 13038; 43506; 48646; 86758; 80722; 77440; 80556 -Ephb3 EphB3 P54754 mouse NCAM-L1 16728 P11627 L1cam mouse Y1232 10272401 DGsFIGQySGKKEKE Bravo_FIGEY X -Tesk2 TESK2 Q924U5 rat Cofilin-1 29271 P45592 Cfl1 rat S3 448444 _____MAsGVAVsDG X X 3313; 3311 -PBK PBK Q96KB5 human PRPK 112858 Q96S44 TP53RK human S250 1981300 RLRGRKRsMVG____ X X -PBK PBK Q96KB5 human ULK1 8408 O75385 ULK1 human S469 483137 IRRsGstsPLGFARA X X -PBK PBK Q96KB5 human H3 8350 P68431 H3C1 human S10 455676 tkQtArkstGGkAPr Histone X X 9701; 9711; 9606; 3465; 3642; 3377; 3475; 3458; 5764; 47398; 8481; 8552; 53348; 29237; 66065; 43185; 64522; 52725 -PBK PBK Q96KB5 human YB-1 4904 P67809 YBX1 human T89 36130583 EDVFVHQtAIkkNNP CSD X X -PBK PBK Q96KB5 human Jun 3725 P05412 JUN human S73 447943 VGLLkLAsPELERLI Jun X X 9164; 3270; 8752; 12714; 77955 -PBK PBK Q96KB5 human YB-1 4904 P67809 YBX1 human S209 7998039 YGrrPQysNPPVQGE X X -PBK PBK Q96KB5 human Jun 3725 P05412 JUN human S63 447686 kNsDLLtsPDVGLLk Jun X X 5464; 9261; 2361; 97721; 91952 -PBK PBK Q96KB5 human GPSM2 29899 P81274 GPSM2 human T457 18412000 LKGKKYKtNsstkVL X X -PBK PBK Q96KB5 human PRDX1 5052 Q06830 PRDX1 human S32 15334103 QFkDIsLsDykGkYV AhpC-TSA X X -PBK PBK Q96KB5 human ULK1 8408 O75385 ULK1 human S533 31868990 AEMrGGRsPRPGssA X X -PBK PBK Q96KB5 human ULK1 8408 O75385 ULK1 human S495 6220991 GVLARKMsLGGGRPY X X -Camkk2 CAMKK2 Q8C078 mouse AMPKA1 65248 P54645 Prkaa1 rat T183 448786 SDGEFLRtsCGSPNY Pkinase X 2535; 2531; 4188; 5256; 50081; 74281 -Camkk2 CAMKK2 Q8C078 mouse AMPKA1 105787 Q5EG47 Prkaa1 mouse T183 448786 sDGEFLRtsCGsPNY Pkinase X 2535; 2531; 4188; 5256; 50081; 74281 -PASK PASK Q96RG2 human PASK 23178 Q96RG2 PASK human T1165 454397 LFYtFCGtIEYCAPE Pkinase X -PASK PASK Q96RG2 human PASK 23178 Q96RG2 PASK human T1161 454396 ERGKLFYtFCGtIEY Pkinase X -PASK PASK Q96RG2 human EEF1A1 1915 P68104 EEF1A1 human T432 2862100 AVRDMrQtVAVGVIk GTP_EFTU_D3 X -PASK PASK Q96RG2 human PASK 23178 Q96RG2 PASK human T307 1868450201 VGRARDGtTFPLSLk X -PASK PASK Q96RG2 human WDR5 11091 P61964 WDR5 human S49 25758598 AGHTkAVsSVKFsPN WD40 X -PASK PASK Q96RG2 human GYS1 100008660 P13834 GYS1 rabbit S641 448237 YRYPRPAsVPPsPSL Glycogen_syn X -PASK PASK Q96RG2 human PDX1 18609 P52946 Pdx1 mouse T152 470134 EENKRTRtAYTRAQL Homeodomain X -Atm ATM D4ACL8 rat DBN1 81653 Q07266 Dbn1 rat S659 472365 SEGYFSQsQEEEFAQ X -EIF2AK3 PERK Q9NZJ5 human PERK 13666 Q9Z2B5 Eif2ak3 mouse Y561 30310301 QCQTESKyDSVSADV X X -EIF2AK3 PERK Q9NZJ5 human FBPase 2203 P09467 FBP1 human S170 1880113501 AGYALYGsATMLVLA X X -EIF2AK3 PERK Q9NZJ5 human PERK 9451 Q9NZJ5 EIF2AK3 human T982 447936 MPAYARHtGQVGTKL Pkinase X -EIF2AK3 PERK Q9NZJ5 human eIF2-alpha 1965 P05198 EIF2S1 human S49 450210 IEGMILLsELsRRRI S1 X -EIF2AK3 PERK Q9NZJ5 human eIF2-alpha 13665 Q6ZWX6 Eif2s1 mouse S52 447635 MILLSELsRrrIRSI S1 X X 3597; 9721; 3398; 5199; 53085; 95797 -EIF2AK3 PERK Q9NZJ5 human eIF2-alpha 1965 P05198 EIF2S1 human S52 447635 MILLsELsRRRIRsI S1 X X 3597; 9721; 3398; 5199; 53085; 95797 -EIF2AK3 PERK Q9NZJ5 human PERK 13666 Q9Z2B5 Eif2ak3 mouse Y615 1256400 NKVDDCNyAIKRIRL Pkinase X X -Insr INSR P15208 mouse STXBP3 20912 Q60770 Stxbp3 mouse Y521 459181 RQKPRTNyLELDRKN Sec1 X -Insr INSR P15208 mouse APS 23921 Q9JID9 Sh2b2 mouse Y618 448842 ARAVENQySFY____ X -Insr INSR P15208 mouse FABP4 11770 P04117 Fabp4 mouse Y20 451170 sSENFDDyMkEVGVG Lipocalin X -Insr INSR P15208 mouse caveolin-1 12389 P49817 Cav1 mouse Y14 448422 VDsEGHLytVPIREQ X 3251 -BRAF BRAF P15056 human NHE1 6548 P19634 SLC9A1 human T653 4729330 LRsYNRHtLVADPyE NEXCaM_BD X X -BRAF BRAF P15056 human EEF1A1 1915 P68104 EEF1A1 human T88 15229616 EtSkyyVtIIDAPGH GTP_EFTU X -BRAF BRAF P15056 human BRAF 673 P15056 BRAF human S465 4959522 tVGQRIGsGsFGtVY PK_Tyr_Ser-Thr X -BRAF BRAF P15056 human MEK1 5604 Q02750 MAP2K1 human S222 448513 LIDsMANsFVGtRSY Pkinase X X 2338; 9121; 3958; 9154; 16211; 86128; 16780; 75262 -BRAF BRAF P15056 human EEF1A2 1917 Q05639 EEF1A2 human S21 5434143 GHVDSGkstttGHLI GTP_EFTU X -BRAF BRAF P15056 human MEK1 5604 Q02750 MAP2K1 human S218 448514 VsGQLIDsMANsFVG Pkinase X X 9121; 3958; 9154; 86128 -BRAF BRAF P15056 human TTK 7272 P33981 TTK human S281 1737603 VPVNLLNsPDCDVkt X -BRAF BRAF P15056 human BAD 572 Q92934 BAD human S99 447862 PFrGrsRsAPPNLWA Bcl-2_BAD X X 9295; 5286; 4366 -BRAF BRAF P15056 human MEK2 5605 P36507 MAP2K2 human S222 448073 VsGQLIDsMANsFVG Pkinase X 9121; 3958; 9154; 86128 -BRAF BRAF P15056 human BAD 572 Q92934 BAD human S75 447860 EIRsRHssyPAGtED Bcl-2_BAD X X 9291; 5284; 9296; 5193; 11865; 94223 -BRAF BRAF P15056 human NANOG 79923 Q9H9S0 NANOG human S68 1394461701 LIQDsPDsStsPKGK X X -BRAF BRAF P15056 human EEF1A1 1915 P68104 EEF1A1 human S21 5434136 GHVDSGkstttGHLI GTP_EFTU X -BRAF BRAF P15056 human BRAF 673 P15056 BRAF human S614 14159399 SHQFEQLsGSILWMA PK_Tyr_Ser-Thr X -BRAF BRAF P15056 human BAD 572 Q92934 BAD human S118 447863 GRELRRMsDEFVDsF Bcl-2_BAD X X 9297 -BRAF BRAF P15056 human BRAF 673 P15056 BRAF human S467 28070701 GQRIGsGsFGtVYkG PK_Tyr_Ser-Thr X -BRAF BRAF P15056 human BRAF 673 P15056 BRAF human T373 458858 APNVHINtIEPVNID X -BRAF BRAF P15056 human MEK2 5605 P36507 MAP2K2 human S226 448074 LIDsMANsFVGtRSY Pkinase X 2338; 9121; 3958; 9154; 16211; 86128; 16780; 75262 -BRAF BRAF P15056 human TTK 7272 P33981 TTK human S436 950200 VFSVskQsPPIsTSk X -BRAF BRAF P15056 human BAD 572 Q92934 BAD human S134 447864 KGLPRPKsAGtAtQM Bcl-2_BAD X X -NEK9 NEK9 Q8TD19 human CSN2 281099 P02666 CSN2 cow S157 2869600 LPLPLLQsWMHQPHQ Casein X -NEK9 NEK9 Q8TD19 human NEK9 91754 Q8TD19 NEK9 human S944 4272073 GQQVGMHskGTQTAK X X -NEK9 NEK9 Q8TD19 human CSN2 281099 P02666 CSN2 cow S72 11334000 HPFAQTQsLVYPFPG X -NEK9 NEK9 Q8TD19 human CSN2 281099 P02666 CSN2 cow S139 2869601 EPFTESQsLTLTDVE Casein X -NEK9 NEK9 Q8TD19 human NEDD1 121441 Q8NHV4 NEDD1 human S377 12737836 EkAGLPRsINTDtLS X -NEK9 NEK9 Q8TD19 human LC3B 81631 Q9GZQ8 MAP1LC3B human T50 37045604 QLPVLDktkFLVPDH ATG8 X X -NEK9 NEK9 Q8TD19 human NEK7 140609 Q8TDX7 NEK7 human S195 4271152 skttAAHsLVGtPyy Pkinase X -NEK9 NEK9 Q8TD19 human NEK6 10783 Q9HC98 NEK6 human S206 448024 sEttAAHsLVGtPyy Pkinase X X -NEK9 NEK9 Q8TD19 human NEK9 91754 Q8TD19 NEK9 human T210 451116 SEYsMAEtLVGtPYY Pkinase X X -MYLK smMLCK Q15746 human MRLC2V 4633 P10916 MYL2 human S15 2846506 KRAGGANsNVFsMFE X X -MYLK smMLCK Q15746 human MRLC1 10398 P24844 MYL9 human T19 1863501 KKRPQRAtsNVFAMF X 3674; 95777 -MYLK smMLCK Q15746 human Caldesmon 373965 P12957 CALD1 chicken T693 3194456 TGtPNKEtAGLKVGV Caldesmon X -MYLK smMLCK Q15746 human Caldesmon 373965 P12957 CALD1 chicken S73 457422 SEVNAQNsVAEEETK Caldesmon X -MYLK smMLCK Q15746 human Caldesmon 373965 P12957 CALD1 chicken S702 456707 GLKVGVSsRINEWLT Caldesmon X -MYLK smMLCK Q15746 human MRLC2 103910 O14950 MYL12B human S20 448595 KRPQRAtsNVFAMFD X X -MYLK smMLCK Q15746 human Caldesmon 373965 P12957 CALD1 chicken T626 14823409 SGMKPAHttAVVsKI Caldesmon X -MYLK smMLCK Q15746 human MRLC1 10398 P24844 MYL9 human S20 1863500 KRPQRAtsNVFAMFD X 3674; 3671; 3675; 95777 -MYLK smMLCK Q15746 human Caldesmon 373965 P12957 CALD1 chicken S658 14823410 KPAKPAAsDLPVPAE Caldesmon X -MYLK smMLCK Q15746 human MRLC2 103910 O14950 MYL12B human T19 448596 KKRPQRAtsNVFAMF X -MYLK smMLCK Q15746 human MRLC2 50685 P18666 Myl12b rat S20 448595 KRPQRAtsNVFAMFD X -Cdc42bpa MRCKA O54874 rat LIMK2 29524 P53670 Limk2 rat T505 448683 SDRKKRYtVVGNPYW PK_Tyr_Ser-Thr X 3841 -CDK15 CDK15 Q96Q40 human PAK4 10298 O96013 PAK4 human S291 2192537 PGPPGPRsPQREPQR X X -Uhmk1 KIS Q63285 rat MBP 618684 P02687 MBP cow S164 451833 GRDsRSGsPMARR__ Myelin_MBP X -Uhmk1 KIS Q63285 rat SYN1 281510 P17599 SYN1 cow S438 2020553 GSHSQTPsPGALPLG X -Uhmk1 KIS Q63285 rat PAM 25508 P14925 Pam rat S949 453092 DRVstEGsDQEKDED X X -KHK KHK P50053 human 14-3-3 eta 7533 Q04917 YWHAH human S25 14159200 ERyDDMAsAMKAVTE 14-3-3 X X -Zap70 ZAP70 P43404 mouse LAT 16797 O54957 Lat mouse Y136 447760 EDDyPNGyLVVLPDS LAT X -Zap70 ZAP70 P43404 mouse LAT 16797 O54957 Lat mouse Y175 448004 SVESCEDyVNVPESE LAT X 3581 -Zap70 ZAP70 P43404 mouse LAT 16797 O54957 Lat mouse Y235 448006 DGEEAPDyENLQELN LAT X 54364; 45170 -Zap70 ZAP70 P43404 mouse LAT 16797 O54957 Lat mouse Y195 448005 SLDGSREyVNVsPEQ LAT X 3584; 20172 -Grk1 GRK1 Q9WVL4 mouse Rhodopsin 212541 P15409 Rho mouse S338 448679 DDAsATAsKtEtsQV X X -Grk1 GRK1 Q9WVL4 mouse Rhodopsin 212541 P15409 Rho mouse S334 448677 PLGDDDAsATAsKtE X -Cdc7 CDC7 Q9Z0H0 mouse NHEJ1 75570 Q3KNJ2 Nhej1 mouse S245 4084901 TQASSSTsPRGTDNQ X -Hipk4 HIPK4 Q3V016 mouse NDEL1 83431 Q9ERR1 Ndel1 mouse S336 1869686801 LGSsRPSsAPGMLPL X -PRKCG PKCG P05129 human HSP90A 3320 P07900 HSP90AA1 human T115 13256102 GtIAksGtkAFMEAL HATPase_c X X -PRKCG PKCG P05129 human DNAJC5 80331 Q9H3Z4 DNAJC5 human S34 10407117 TSDDIKKsYRKLALk DnaJ X X -PRKCG PKCG P05129 human Tau iso8 4137 P10636-8 MAPT human S352 487459 DFKDrVQskIGsLDN Tubulin-binding X -PRKCG PKCG P05129 human DAB2 1601 P98082 DAB2 human S24 451211 QAAPKAPsKKEKKKG X -PRKCG PKCG P05129 human CACNA1C 100101555 P15381 CACB rabbit S1928 455278 ASLGRRAsFHLECLK CAC1F_C X -PRKCG PKCG P05129 human Kv3.4 3749 Q03721 KCNC4 human S9 451076 ISSVCVssYRGRKsG Potassium_chann X -PRKCG PKCG P05129 human SYN1 20964 O88935 Syn1 mouse S553 448377 ArPPAsPsPQrQAGA X -PRKCG PKCG P05129 human GluR4 29629 P19493 Gria4 rat S862 448810 TRNKARLsITGSVGE X -PRKCG PKCG P05129 human MOR-1 18390 P42866 Oprm1 mouse S363 447783 STIEQQNsARIRQNt X -PRKCG PKCG P05129 human Kv3.4 3749 Q03721 KCNC4 human S21 451078 KsGNKPPsKTCLKEE Potassium_chann X -PRKCG PKCG P05129 human AID 11628 Q9WVE0 Aicda mouse S3 20660600 _____MDsLLMKQKK X -PRKCG PKCG P05129 human CACNA1C 100101555 P15381 CACB rabbit S533 453091 RIsKSKFsRYWRRWN X -PRKCG PKCG P05129 human SYN1 20964 O88935 Syn1 mouse S551 451574 PAArPPAsPsPQrQA X -PRKCG PKCG P05129 human HSP90A 3320 P07900 HSP90AA1 human T425 30957300 KkCLELFtELAEDkE HSP90 X X -PRKCG PKCG P05129 human Tau iso8 4137 P10636-8 MAPT human S324 449328 kVtskCGsLGNIHHk Tubulin-binding X -PRKCG PKCG P05129 human SLC38A3 252919 Q9JHZ9 Slc38a3 rat S52 19001700 KGFLQQSsSKEPHFT X -PRKCG PKCG P05129 human DRAK2 170904 Q91XS8 Stk17b rat S350 1735800 PEDDSLLsKRFRFDD X X -PRKCG PKCG P05129 human MLP 17357 P28667 Marcksl1 mouse S93 477961 PKKKKKFsFKKPFKL MARCKS X -PRKCG PKCG P05129 human CHAT iso3 1103 P28329-3 CHAT human S440 449057 VPTYESAsIRRFQEG Carn_acyltransf X -PRKCG PKCG P05129 human CHAT iso3 1103 P28329-3 CHAT human S347 454036 LKHVTQssRKLIRAD Carn_acyltransf X -PRKCG PKCG P05129 human NGFR 4804 P08138 NGFR human S277 9993601 IAFKRWNsCKQNKQG TNFR_16_TM X -PRKCG PKCG P05129 human CHAT iso3 1103 P28329-3 CHAT human T255 454038 TVLVKDStNRDSLDM Carn_acyltransf X -PRKCG PKCG P05129 human mGluR5 24418 P31424 Grm5 rat S839 455778 VRSAFTTstVVRMHV X -PRKCG PKCG P05129 human Tau iso8 4137 P10636-8 MAPT human S293 449327 NVQskCGsKDNIkHV Tubulin-binding X -PRKCG PKCG P05129 human GSK3A 2931 P49840 GSK3A human S21 448584 sGrARtssFAEPGGG X 9337; 9316; 9331; 5090; 9327; 8452; 8566 -PRKCG PKCG P05129 human HNF4 alpha 25735 P22449 Hnf4a rat S87 478421 CKGFFRRsVRKNHMY zf-C4 X -PRKCG PKCG P05129 human fascin 14086 Q61553 Fscn1 mouse S39 450888 KVNASAssLkkKQIW Fascin X -PRKCG PKCG P05129 human Tau iso8 4137 P10636-8 MAPT human S258 487453 PDLkNVKskIGstEN Tubulin-binding X -PRKCG PKCG P05129 human Kv3.4 3749 Q03721 KCNC4 human S8 451075 MISSVCVssYRGRKs Potassium_chann X -PRKCG PKCG P05129 human NADK 65220 O95544 NADK human S64 467326 kEFRRtRsLHGPCPV X X -PRKCG PKCG P05129 human KIR3DL1 3811 P43629 KIR3DL1 human S415 990302 QRKITRPsQRPKtPP X -PRKCG PKCG P05129 human GSK3B 2932 P49841 GSK3B human S9 449111 SGRPRttsFAEsCkP X 9336; 9331; 9327; 9323; 9322; 9325; 5558; 8566; 79774; 8466; 25462; 14026; 14332; 14310; 14630 -PRKCG PKCG P05129 human TRPC3 7222 Q13507 TRPC3 human T646 20612407 LQISLGRtVKDIFKF Ion_trans X -PRKCG PKCG P05129 human MMP14 4323 P50281 MMP14 human T567 7992400 FFFRRHGtPRRLLyC DUF3377 X -PRKCG PKCG P05129 human P70S6KB 6199 Q9UBS0 RPS6KB2 human S473 450071 PPSGTKKsKRGRGRP X X -PRKCG PKCG P05129 human ARHGEF7 8874 Q14155 ARHGEF7 human S518 454356 LSASPRMsGFIYQGK PH X X -PRKCG PKCG P05129 human HMGA1 117062 Q8K585 Hmga1 rat S44 479856 PGTALVGsQKEPSEV X -PRKCG PKCG P05129 human GJA1 24392 P08050 Gja1 rat S368 447813 QRPssRAssRAssRP X 3511; 52559 -PRKCG PKCG P05129 human GRK2 156 P25098 GRK2 human S29 447724 ATPAARAskkILLPE X -PRKCG PKCG P05129 human C5aR 728 P21730 C5AR1 human S334 448819 sVVREsKsFTRsTVD X -PRKCG PKCG P05129 human Kv3.4 3749 Q03721 KCNC4 human S15 451077 ssYRGRKsGNKPPsK Potassium_chann X -PRKCG PKCG P05129 human CACNA1C 100101555 P15381 CACB rabbit S528 486358 ARLAHRIsKSKFsRY X -PRKCG PKCG P05129 human DNAJC5 80331 Q9H3Z4 DNAJC5 human S10 448129 DQRQRsLstsGEsLy X X -PRKCG PKCG P05129 human APTX 54840 Q7Z2E3 APTX human T125 9397200 AKNPGLEtHRKRKRs X X -PRKCG PKCG P05129 human CD5 921 P06127 CD5 human T434 450129 MsFHRNHtAtVRsHA X -PRKCG PKCG P05129 human CHAT iso3 1103 P28329-3 CHAT human S476 454037 HKAAVPAsEKLLLLK Carn_acyltransf X -PRKCG PKCG P05129 human GLRB 14658 P48168 Glrb mouse S425 2048205 NDFSIVGsLPRDFEL Neur_chan_memb X -PRKCG PKCG P05129 human HSP90A 3320 P07900 HSP90AA1 human T603 12078914 PCCIVtstyGWtANM HSP90 X X -PRKCG PKCG P05129 human CHAT iso3 1103 P28329-3 CHAT human S346 454035 LLKHVTQssRKLIRA Carn_acyltransf X -PRKCG PKCG P05129 human ARHGEF7 8874 Q14155 ARHGEF7 human S761 14569926 DSLGRRSsLsRLEPS X X -PRKCG PKCG P05129 human MLP 17357 P28667 Marcksl1 mouse S104 465848 PFKLsGLsFkRNRkE MARCKS X -PRKCG PKCG P05129 human CACNA1C 100101555 P15381 CACB rabbit S1674 480102 QGLVGKPsQRNALSL X -PRKCG PKCG P05129 human CD5 921 P06127 CD5 human T436 450130 FHRNHtAtVRsHAEN X -PRKCG PKCG P05129 human NADK 65220 O95544 NADK human S46 1210510 RGRAKsrsLsAsPAL X X -PRKCG PKCG P05129 human HMGA1 117062 Q8K585 Hmga1 rat S64 3136103 PRGRPKGsKNKGTAK X -Akt2 Akt2 P47197 rat SFRS5 29667 Q09167 Srsf5 rat S86 3685800 GRGRGRYsDRFSSRR X -Akt2 Akt2 P47197 rat S6 29304 P62755 Rps6 rat S235 448092 IAKRRRLssLRAsts X 5006; 4856; 4857; 4858; 4851; 4803; 2211; 3945; 3985; 5316; 4854; 8520; 48319; 40643; 9865; 38573; 14733; 27036; 34411; 62016; 62788; 81736; 97935; 99457; 15448 -Akt2 Akt2 P47197 rat S6 29304 P62755 Rps6 rat S236 448093 AKRRRLssLRAstsK X 5006; 4856; 4857; 4858; 4851; 4803; 2211; 3945; 3985; 5316; 4854; 8520; 48319; 40643; 9865; 38573; 14733; 27036; 34411; 62016; 62788; 81736; 97935; 99457; 15448 -VRK3 VRK3 Q8IV63 human BAF 8815 O75531 BANF1 human S4 458302 ____MttsQkHRDFV BAF X X -FLT3 FLT3 P36888 human FLT3 2322 P36888 FLT3 human Y955 454873 ADAEEAMyQNVDGRV X -FLT3 FLT3 P36888 human FLT3 2322 P36888 FLT3 human Y726 448644 kEHNFSFyPtFQSHP PK_Tyr_Ser-Thr X -FLT3 FLT3 P36888 human FLT3 2322 P36888 FLT3 human Y591 448190 SSDNEyFyVDFREyE X 3474; 3466; 3461; 3464; 48437; 25619; 23991; 60413 -FLT3 FLT3 P36888 human SIRT3 23410 Q9NTG7 SIRT3 human Y226 1881476100 KGLLLRLyTQNIDGL X -FLT3 FLT3 P36888 human EphB6 418308 Q07497 EPHB6 chicken Y594 449769 SKRRETPyTDRLQQy EphA2_TM X -FLT3 FLT3 P36888 human IDH1 3417 O75874 IDH1 human Y391 462261 PNVQRsDyLNTFEFM Iso_dh X -FLT3 FLT3 P36888 human IDH2 3418 P48735 IDH2 human Y107 1914598 sALATQkysVAVkCA Iso_dh X -FLT3 FLT3 P36888 human FLT3 2322 P36888 FLT3 human Y969 454874 VSECPHtyQNrrPFS X 3463 -FLT3 FLT3 P36888 human SHP-2 5781 Q06124 PTPN11 human Y62 449573 KIQNtGDyyDLyGGE SH2 X -FLT3 FLT3 P36888 human FLT3 2322 P36888 FLT3 human Y842 454872 DIMSDsNyVVRGNAR PK_Tyr_Ser-Thr X 4577 -FLT3 FLT3 P36888 human FLT3 2322 P36888 FLT3 human Y599 448643 VDFREyEyDLkWEFP X -FLT3 FLT3 P36888 human FLT3 2322 P36888 FLT3 human Y589 448189 TGSSDNEyFyVDFRE X 3464; 48437; 25619; 23991; 60413 -FLT3 FLT3 P36888 human PDHA1 5160 P08559 PDHA1 human Y301 454753 MsDPGVsyRtREEIQ E1_dh X -FLT3 FLT3 P36888 human PDHK1 5163 Q15118 PDK1 human Y243 462384 ARRLCDLyyINSPEL X -FLT3 FLT3 P36888 human EphB6 418308 Q07497 EPHB6 chicken Y601 461924 yTDRLQQyISTRGLG EphA2_TM X -Jak1 JAK1 P52332 mouse SH2-B-beta 89817 Q62985 Sh2b1 rat Y439 448753 DRLSQGAyGGLSDRP X -Jak1 JAK1 P52332 mouse SHP-2 19247 P35235 Ptpn11 mouse Y327 451496 NSKPKKSyIATQGCL Y_phosphatase X -Jak1 JAK1 P52332 mouse SH2-B-beta 89817 Q62985 Sh2b1 rat Y494 448754 VHPLSTPyPPLDTPE X -Jak1 JAK1 P52332 mouse SHP-2 19247 P35235 Ptpn11 mouse Y304 451495 PNEPVSDyINANIIM Y_phosphatase X -Jak1 JAK1 P52332 mouse GSK3B 56637 Q9WV60 Gsk3b mouse Y216 448569 RGEPNVsyICsRYYR Pkinase X -Jak1 JAK1 P52332 mouse IL7R 16197 P16872 Il7r mouse Y449 451291 VLNQEEAyVTMSSFY X -SRPK1 SRPK1 Q96SB4 human LBR G1N806 LBR turkey S78 18911472 SPSRRSRsRsRsRsP X -SRPK1 SRPK1 Q96SB4 human SRPK1 6732 Q96SB4 SRPK1 human S309 468861 RPNKQEEsEsPVERP X X -SRPK1 SRPK1 Q96SB4 human SF2 6426 Q07955 SRSF1 human S219 2303913 RsRsRsRsNsRsRsy X -SRPK1 SRPK1 Q96SB4 human SRPK1 6732 Q96SB4 SRPK1 human S33 3209895 sEtQHRGsAPHsEsD X X -SRPK1 SRPK1 Q96SB4 human LBR G1N806 LBR turkey S84 14575424 RsRsRsRsPGRPAKG X -SRPK1 SRPK1 Q96SB4 human SF2 6426 Q07955 SRSF1 human S209 2303911 yGRsRsRsRsRsRsR X -SRPK1 SRPK1 Q96SB4 human SF2 6426 Q07955 SRSF1 human S223 2303916 RsRsNsRsRsysPRR X -SRPK1 SRPK1 Q96SB4 human SF2 6426 Q07955 SRSF1 human S215 2303908 RsRsRsRsRsRsNsR X -SRPK1 SRPK1 Q96SB4 human RBM8A 9939 Q9Y5S9 RBM8A human S168 456535 GGRRRsRsPDRRRR_ X -SRPK1 SRPK1 Q96SB4 human SF2 6426 Q07955 SRSF1 human S207 2303910 PsyGRsRsRsRsRsR X -SRPK1 SRPK1 Q96SB4 human RBM20 309544 E9PT37 Rbm20 rat S638 31086436 YGPERPRsRsPMsRs X X -SRPK1 SRPK1 Q96SB4 human SRPK1 6732 Q96SB4 SRPK1 human S587 25724400 LIVAGkYskEFFTKK Pkinase X -SRPK1 SRPK1 Q96SB4 human RBM8A 9939 Q9Y5S9 RBM8A human S166 456534 RRGGRRRsRsPDRRR X -SRPK1 SRPK1 Q96SB4 human RBM4 5936 Q9BWF3 RBM4 human S309 476783 SyYGRDRsPLRRATA X -SRPK1 SRPK1 Q96SB4 human LBR G1N806 LBR turkey S82 14575430 RSRsRsRsRsPGRPA X -SRPK1 SRPK1 Q96SB4 human SF2 6426 Q07955 SRSF1 human S225 2303914 RsNsRsRsysPRRsR X -SRPK1 SRPK1 Q96SB4 human LBR G1N806 LBR turkey S80 14575427 SRRSRsRsRsRsPGR X -SRPK1 SRPK1 Q96SB4 human SF2 6426 Q07955 SRSF1 human S211 2303912 RsRsRsRsRsRsRsR X -SRPK1 SRPK1 Q96SB4 human SF2 6426 Q07955 SRSF1 human S213 2303907 RsRsRsRsRsRsRsN X -SRPK1 SRPK1 Q96SB4 human SF2 6426 Q07955 SRSF1 human S221 2303917 RsRsRsNsRsRsysP X -SRPK1 SRPK1 Q96SB4 human SF2 6426 Q07955 SRSF1 human S217 2303909 RsRsRsRsRsNsRsR X -SRPK1 SRPK1 Q96SB4 human SF2 6426 Q07955 SRSF1 human S227 2303915 NsRsRsysPRRsRGs X -SRPK1 SRPK1 Q96SB4 human SRPK1 6732 Q96SB4 SRPK1 human T326 25724401 ENPPNKMtQEKLEEs X X -SRPK1 SRPK1 Q96SB4 human SF2 6426 Q07955 SRSF1 human S205 454790 RsPsyGRsRsRsRsR X -SRPK1 SRPK1 Q96SB4 human RBM20 309544 E9PT37 Rbm20 rat S640 31086439 PERPRsRsPMsRsLS X X -Pdpk1 PDK1 O55173 rat SGK1 29517 Q06226 Sgk1 rat T256 448431 EHNGTTstFCGTPEY Pkinase X -Pdpk1 PDK1 O55173 rat PKCZ 25522 P09217 Prkcz rat T560 447572 TSEPVQLtPDDEDVI Pkinase_C X X -Pdpk1 PDK1 O55173 rat p70S6K 83840 P67999 Rps6kb1 rat T412 448607 NQVFLGFtYVAPSVL Pkinase_C X 9206; 9234; 9205; 97596 -Pdpk1 PDK1 O55173 rat PKCZ 25522 P09217 Prkcz rat T410 447510 GPGDTTStFCGTPNY Pkinase X X 9378; 2060 -Pdpk1 PDK1 O55173 rat KIDINS220 116478 Q9EQG6 Kidins220 rat S918 451418 RTITRQMsFDLTKLL KAP_NTPase X -PRKCZ PKCZ Q05513 human PTEN 5728 P60484 PTEN human S380 448313 EPDHyRYsDttDsDP X 9551; 9554; 9549; 7960 -PRKCZ PKCZ Q05513 human MARK2 2011 Q7KZI7 MARK2 human T596 453427 rGVssRstFHAGQLR X X -PRKCZ PKCZ Q05513 human CABP4 73660 Q8VHC5 Cabp4 mouse S37 1315600 PALTRRRsKKESWHP X X -PRKCZ PKCZ Q05513 human Tau iso8 4137 P10636-8 MAPT human S352 487459 DFKDrVQskIGsLDN Tubulin-binding X -PRKCZ PKCZ Q05513 human RhoE 390 P61587 RND3 human S210 27933600 KNVKRNKsQRATKRI X -PRKCZ PKCZ Q05513 human BVR 644 P53004 BLVRA human S230 478716 LKRNRyLsFHFksGs Biliv-reduc_cat X X -PRKCZ PKCZ Q05513 human Notch 1 18128 Q01705 Notch1 mouse S1791 35502500 LkPLKNAsDGALMDD X X -PRKCZ PKCZ Q05513 human TNNI3 511094 P08057 TNNI3 cow S44 450690 AKKKSKIsAsRKLQL X -PRKCZ PKCZ Q05513 human CACNA1C 100101555 P15381 CACB rabbit S1928 455278 ASLGRRAsFHLECLK CAC1F_C X -PRKCZ PKCZ Q05513 human GSK3B 2932 P49841 GSK3B human S147 51621301 YRVARHYsRAKQTLP Pkinase X -PRKCZ PKCZ Q05513 human NUMB iso3 8650 P49757-3 NUMB human S7 487518 _MNKLRQsFRRKKDV X -PRKCZ PKCZ Q05513 human LKB1 iso2 6794 Q15831-2 STK11 human S399 27933602 DLSGEEAsRPAPQ__ X X -PRKCZ PKCZ Q05513 human ATP1B1 25650 P07340 Atp1b1 rat S11 29573988 GKAkEEGsWkkFIWN Na_K-ATPase X -PRKCZ PKCZ Q05513 human AQP9 366 O43315 AQP9 human S222 477184 MNPARDLsPRLFTAL MIP X -PRKCZ PKCZ Q05513 human ATP1A1 24211 P06685 Atp1a1 rat S16 449086 KyEPAAVsEHGDkks X 4020 -PRKCZ PKCZ Q05513 human SRC-3 8202 Q9Y6Q9 NCOA3 human S1042 4252806 DDLVGPPsNLEGQsD X -PRKCZ PKCZ Q05513 human occludin 100506658 Q16625 OCLN human T438 19083405 LYKRNFDtGLQEyKs Occludin_ELL X X -PRKCZ PKCZ Q05513 human MARK3 4140 P27448 MARK3 human T564 466001 RGTASRStFHGQPRE X X -PRKCZ PKCZ Q05513 human PLA2G4A 5321 P47712 PLA2G4A human T376 1869344400 GskFFMGtVVKKYEE PLA2_B X -PRKCZ PKCZ Q05513 human PAK4 10298 O96013 PAK4 human S99 2192540 MsVTRsNsLRRDsPP X X -PRKCZ PKCZ Q05513 human PPP1R14A 94274 Q96A00 PPP1R14A human T38 449098 QkRHARVtVkYDRRE PP1_inhibitor X -PRKCZ PKCZ Q05513 human p47phox 653361 P14598 NCF1 human S320 451726 QRsRKRLsQDAYRRN NECFESHC X -PRKCZ PKCZ Q05513 human EphA2 1969 P29317 EPHA2 human S892 3189622 ADFDPRVsIRLPsts X X -PRKCZ PKCZ Q05513 human PHGDH 26227 O43175 PHGDH human T57 4730705 GLIVRsAtkVtADVI 2-Hacid_dh X X -PRKCZ PKCZ Q05513 human PIAS4 51588 Q8N2W9 PIAS4 human S18 56589715 MVMSFRVsDLQMLLG X -PRKCZ PKCZ Q05513 human NUMB iso3 8650 P49757-3 NUMB human S284 470030 sPFKRQLsLRINELP NumbF X -PRKCZ PKCZ Q05513 human CTNNB1 1499 P35222 CTNNB1 human S45 447488 GATtTAPsLsGkGNP X 9565; 9564; 24710; 70034; 19807; 96727; 77605 -PRKCZ PKCZ Q05513 human AID 11628 Q9WVE0 Aicda mouse S3 20660600 _____MDsLLMKQKK X -PRKCZ PKCZ Q05513 human CACNA1C 100101555 P15381 CACB rabbit S533 453091 RIsKSKFsRYWRRWN X -PRKCZ PKCZ Q05513 human PHGDH 26227 O43175 PHGDH human T78 4730715 QVVGrAGtGVDNVDL 2-Hacid_dh X X -PRKCZ PKCZ Q05513 human SRC-3 8202 Q9Y6Q9 NCOA3 human T1064 4252807 LHtLLsNtDAtGLEE Nuc_rec_co-act X -PRKCZ PKCZ Q05513 human MYH10 4628 P35580 MYH10 human S1935 4730818 LRrGGPIsFsssrSG X -PRKCZ PKCZ Q05513 human p47phox 114553 F1M707 Ncf1 rat S316 451725 AQSIHQRsRKRLsQD NECFESHC X -PRKCZ PKCZ Q05513 human ERK5 23939 Q9WVS8 Mapk7 mouse S486 450251 LKAALLKsLRSRLRD X -PRKCZ PKCZ Q05513 human CASP9 842 P55211 CASP9 human S144 458346 GDVGALEsLRGNADL X X -PRKCZ PKCZ Q05513 human HMGB1 3146 P09429 HMGB1 human S39 7320388 PDAsVNFsEFskkCs HMG_box_2 X -PRKCZ PKCZ Q05513 human Tau iso8 4137 P10636-8 MAPT human S324 449328 kVtskCGsLGNIHHk Tubulin-binding X -PRKCZ PKCZ Q05513 human Snail1 6615 O95863 SNAI1 human S249 1867725600 ARTFsRMsLLHKHQE X X -PRKCZ PKCZ Q05513 human IRS1 25467 P35570 Irs1 rat S498 451680 PGATMGTsPALtGDE X -PRKCZ PKCZ Q05513 human CHAT iso3 1103 P28329-3 CHAT human S440 449057 VPTYESAsIRRFQEG Carn_acyltransf X -PRKCZ PKCZ Q05513 human eNOS 287024 P29473 NOS3 cow T497 447885 AGITRKktFKEVANA X -PRKCZ PKCZ Q05513 human TNNI3 511094 P08057 TNNI3 cow S46 450691 KKSKIsAsRKLQLKT X -PRKCZ PKCZ Q05513 human YAP1 10413 P46937 YAP1 human S109 452305 ksHsRQAstDAGtAG X 46931; 53749 -PRKCZ PKCZ Q05513 human IRAP 171105 P97629 Lnpep rat S91 459010 RSSGLRNsATGYRQS X -PRKCZ PKCZ Q05513 human LKB1 20869 Q9WTK7 Stk11 mouse S431 448147 sNKIRRLsACKQQ__ X 3482 -PRKCZ PKCZ Q05513 human P311 9315 Q16612 NREP human S59 457551 LGSSELRsPRISYLH Alveol-reg_P311 X -PRKCZ PKCZ Q05513 human Tau iso8 4137 P10636-8 MAPT human S293 449327 NVQskCGsKDNIkHV Tubulin-binding X -PRKCZ PKCZ Q05513 human GEM 2669 P55040 GEM human S261 450647 AyQKRKEsMPRKARR X -PRKCZ PKCZ Q05513 human RAGE 177 Q15109 AGER human S391 4731275 ERAELNQsEEPEAGE X X -PRKCZ PKCZ Q05513 human p47phox 653361 P14598 NCF1 human S304 449406 GAPPRRssIRNAHsI NECFESHC X X -PRKCZ PKCZ Q05513 human IRS1 25467 P35570 Irs1 rat S570 451681 RLPGYRHsAFVPTHS X -PRKCZ PKCZ Q05513 human NFkB-p65 5970 Q04206 RELA human S311 449966 RtyEtFksIMkksPF X -PRKCZ PKCZ Q05513 human PARD6A 50855 Q9NPB6 PARD6A human S345 15714600 RGDGSGFsL______ X -PRKCZ PKCZ Q05513 human SRC-3 8202 Q9Y6Q9 NCOA3 human S1062 4252805 DQLHtLLsNtDAtGL Nuc_rec_co-act X -PRKCZ PKCZ Q05513 human CDK5R1 12569 P61809 Cdk5r1 mouse S33 13421403 HYTAVQNsKNAKDKN X X -PRKCZ PKCZ Q05513 human PAR3-alpha 81918 Q9Z340 Pard3 rat S827 467266 REGFGRQsMSEKRtK X -PRKCZ PKCZ Q05513 human IRS1 25467 P35570 Irs1 rat S612 447562 DDGyMPMsPGVAPVP X 3193; 2386; 3203 -PRKCZ PKCZ Q05513 human SRC-3 8202 Q9Y6Q9 NCOA3 human T1059 4252801 ALLDQLHtLLsNtDA Nuc_rec_co-act X -PRKCZ PKCZ Q05513 human MYH10 4628 P35580 MYH10 human S1956 465600 EGAsLELsDDDtEsK X -PRKCZ PKCZ Q05513 human occludin 100506658 Q16625 OCLN human T404 471472 HyEtDyttGGEsCDE X X -PRKCZ PKCZ Q05513 human SRC-3 8202 Q9Y6Q9 NCOA3 human S1033 4252802 NRPLLRNsLDDLVGP X -PRKCZ PKCZ Q05513 human PHGDH 26227 O43175 PHGDH human S55 27457668 CEGLIVRsAtkVtAD 2-Hacid_dh X X -PRKCZ PKCZ Q05513 human Vimentin 7431 P08670 VIM human S34 455454 srsyVttstrtysLG Filament_head X -PRKCZ PKCZ Q05513 human KLF10 7071 Q13118 KLF10 human S384 5263526 GkTYFKssHLkAHTR X -PRKCZ PKCZ Q05513 human Tau iso8 4137 P10636-8 MAPT human S258 487453 PDLkNVKskIGstEN Tubulin-binding X -PRKCZ PKCZ Q05513 human PAK5 57144 Q9P286 PAK5 human S99 29574070 ISVTRSNsLRKESPP X -PRKCZ PKCZ Q05513 human IRS1 25467 P35570 Irs1 rat S318 451399 MVGGkPGsFRVRAss X 5610 -PRKCZ PKCZ Q05513 human GSK3B 2932 P49841 GSK3B human S9 449111 SGRPRttsFAEsCkP X 9336; 9331; 9327; 9323; 9322; 9325; 5558; 8566; 79774; 8466; 25462; 14026; 14332; 14310; 14630 -PRKCZ PKCZ Q05513 human ZO2 403854 Q95168 TJP2 dog S257 28700303 PDARHAGsRsRsREH X -PRKCZ PKCZ Q05513 human MYH10 4628 P35580 MYH10 human S1937 2017900 rGGPIsFsssrSGRR X X -PRKCZ PKCZ Q05513 human PKCZ 18762 Q02956 Prkcz mouse S186 3136104 TCRRHMDsVMPSQEP X -PRKCZ PKCZ Q05513 human P70S6KB 6199 Q9UBS0 RPS6KB2 human S473 450071 PPSGTKKsKRGRGRP X -PRKCZ PKCZ Q05513 human PKCZ 18762 Q02956 Prkcz mouse S113 5250802 PCPGEDKsIYRRGAR X -PRKCZ PKCZ Q05513 human AQP9 366 O43315 AQP9 human S11 477183 EGAEKGKsFKQRLVL X X -PRKCZ PKCZ Q05513 human SP1 6667 P08047 SP1 human T668 452043 SYCGKRFtRsDELQR zf-C2H2 X X -PRKCZ PKCZ Q05513 human BAX 581 Q07812 BAX human S184 451017 VAGVLTAsLtIWKKM TM X X -PRKCZ PKCZ Q05513 human SMARCD3 6604 Q6STE5 SMARCD3 human S247 27422800 VKRPGDLsVRCTLLL X X -PRKCZ PKCZ Q05513 human LKB1 6794 Q15831 STK11 human S428 448147 SSkIRRLsACkQQ__ X X 3482 -PRKCZ PKCZ Q05513 human LC3B 81631 Q9GZQ8 MAP1LC3B human T50 37045604 QLPVLDktkFLVPDH ATG8 X X -PRKCZ PKCZ Q05513 human NR1H4 iso2 9971 Q96RI1-2 NR1H4 human T442 3333402 GRLTELRtFNHHHAE Hormone_recep X -PRKCZ PKCZ Q05513 human occludin 100506658 Q16625 OCLN human T424 19083406 IREYPPItSDQQRQL Occludin_ELL X X -PRKCZ PKCZ Q05513 human CACNA1C 100101555 P15381 CACB rabbit S528 486358 ARLAHRIsKSKFsRY X -PRKCZ PKCZ Q05513 human IRS1 3667 P35568 IRS1 human S323 451399 MVGGKPGsFRVRAss X X 5610 -PRKCZ PKCZ Q05513 human SP1 6667 P08047 SP1 human T681 470069 QRHKRtHtGEkkFAC X X -PRKCZ PKCZ Q05513 human HMGB1 3146 P09429 HMGB1 human S53 25604400 sERWktMsAkEKGkF HMG_box_2 X -PRKCZ PKCZ Q05513 human p47phox 653361 P14598 NCF1 human S315 451725 AHsIHQRsRKRLsQD NECFESHC X -PRKCZ PKCZ Q05513 human ADD2 119 P35612 ADD2 human S713 449802 KKKFRtPsFLKKsKK X -PRKCZ PKCZ Q05513 human ADD1 118 P35611 ADD1 human S726 449829 KKKFRtPsFLKKsKK X -PRKCZ PKCZ Q05513 human SLP-2 30968 Q9UJZ1 STOML2 human S17 20745207 GALLLRGsLLASGRA X X -PRKCZ PKCZ Q05513 human Vimentin 7431 P08670 VIM human S39 451766 ttstrtysLGsALrP Filament_head X 13614 -PRKCZ PKCZ Q05513 human SRC-3 8202 Q9Y6Q9 NCOA3 human T1114 4252804 KAGLYGQtYPAQGPP X -PRKCZ PKCZ Q05513 human p47phox 653361 P14598 NCF1 human S328 449404 QDAYRRNsVRFLQQR NECFESHC X -PRKCZ PKCZ Q05513 human RED1 104 P78563 ADARB1 human S211 23138309 GDLSLSAsPVPAsLA X X -PRKCZ PKCZ Q05513 human NR0B2 8431 Q15466 NR0B2 human T55 28702400 QLCAPHRtCrEALDV Hormone_recep X X -PRKCZ PKCZ Q05513 human CHAT iso3 1103 P28329-3 CHAT human S476 454037 HKAAVPAsEKLLLLK Carn_acyltransf X -PRKCZ PKCZ Q05513 human YAP1 10413 P46937 YAP1 human T110 452306 sHsRQAstDAGtAGA X -PRKCZ PKCZ Q05513 human HMGB1 3146 P09429 HMGB1 human S181 20506700 GVVkAEKsKKKKEEE X -PRKCZ PKCZ Q05513 human PKCZ 18762 Q02956 Prkcz mouse T560 447572 TSEPVQLtPDDEDVI Pkinase_C X -PRKCZ PKCZ Q05513 human HABP4 22927 Q5JVS0 HABP4 human T375 11380903 GRGARGGtRGGRGRI IHABP4_N X -PRKCZ PKCZ Q05513 human IKKB 3551 O14920 IKBKB human S177 447492 AkELDQGsLCtsFVG Pkinase X 2078; 2697; 2694; 14938; 92255; 36516; 36214 -PRKCZ PKCZ Q05513 human BVR 644 P53004 BLVRA human S149 486325 GkDLLkGsLLFTAGP Biliv-reduc_cat X X -PRKCZ PKCZ Q05513 human IRS1 3667 P35568 IRS1 human S441 1990800 SPCDFRSsFRsVtPD X -PRKCZ PKCZ Q05513 human IRAP 171105 P97629 Lnpep rat S80 459009 SAKLLGMsFMNRSSG X -PRKCZ PKCZ Q05513 human KIBRA 23286 Q8IX03 WWC1 human S978 5310901 KRPSsVKsLRSERLI X -PRKCZ PKCZ Q05513 human SRC-3 8202 Q9Y6Q9 NCOA3 human T1067 4252800 LLsNtDAtGLEEIDR Nuc_rec_co-act X -PRKCZ PKCZ Q05513 human SRC-3 8202 Q9Y6Q9 NCOA3 human S1048 4252803 PsNLEGQsDERALLD Nuc_rec_co-act X -PRKCZ PKCZ Q05513 human PTEN 5728 P60484 PTEN human T383 448315 HyRYsDttDsDPENE X 9554; 9549; 7960 -PRKCZ PKCZ Q05513 human occludin 100506658 Q16625 OCLN human T403 471471 DHyEtDyttGGEsCD X X -PRKCZ PKCZ Q05513 human IRS1 25467 P35570 Irs1 rat S307 447558 TEsITATsPASMVGG X 2381 -PRKCZ PKCZ Q05513 human SP1 6667 P08047 SP1 human S670 2255401 CGKRFtRsDELQRHK zf-C2H2 X X -PRKCZ PKCZ Q05513 human IKKB 3551 O14920 IKBKB human S181 447489 DQGsLCtsFVGTLQy Pkinase X 2697; 2694; 14938; 92255; 36516; 36214 -PRKCZ PKCZ Q05513 human KIBRA 23286 Q8IX03 WWC1 human S975 5310900 VRMKRPSsVKsLRSE X -PRKCZ PKCZ Q05513 human KLF10 7071 Q13118 KLF10 human T445 20573500 FMRSDHLtkHARRHL zf-C2H2 X -PRKCZ PKCZ Q05513 human SP1 6667 P08047 SP1 human S641 470040 GKVYGKtsHLRAHLR zf-C2H2 X X -PRKCZ PKCZ Q05513 human HABP4 22927 Q5JVS0 HABP4 human T354 11380902 RKPANDItSQLEINF IHABP4_N X -PRKCZ PKCZ Q05513 human CACNA1C 100101555 P15381 CACB rabbit S1674 480102 QGLVGKPsQRNALSL X -PRKCZ PKCZ Q05513 human LKB1 6794 Q15831 STK11 human S307 7710000 IRQIRQHsWFRkKHP Pkinase X X -PRKCZ PKCZ Q05513 human PFKFB2 287019 P26285 PFKFB2 cow T476 465673 TPLSSSNtIRRPRNY X -PRKCZ PKCZ Q05513 human JAM-A 16456 O88792 F11r mouse S285 467829 kVIysQPstRsEGEF X X -PRKCZ PKCZ Q05513 human PTEN 5728 P60484 PTEN human T382 448314 DHyRYsDttDsDPEN X 9554; 9549; 7960 -PRKCZ PKCZ Q05513 human IRS1 25467 P35570 Irs1 rat S24 455604 GYLRKPKsMHKRFFV PH X -PRKCZ PKCZ Q05513 human TRAF2 7186 Q12933 TRAF2 human S55 7378202 QCGHRYCsFCLASIL zf-C3HC4 X X -PRKCZ PKCZ Q05513 human NRF2 4780 Q16236 NFE2L2 human S40 450082 SREVFDFsQRRkEYE X -PRKCZ PKCZ Q05513 human NUMB iso3 8650 P49757-3 NUMB human S265 456490 EQLARQGsFRGFPAL NumbF X 4140; 9878 -PRKCZ PKCZ Q05513 human RED1 104 P78563 ADARB1 human S216 1040254700 SAsPVPAsLAQPPLP X X -PRKCZ PKCZ Q05513 human NUMB 18222 Q9QZS3 Numb mouse S295 470030 sPFKRQLsLRINELP NumbF X -PRKCZ PKCZ Q05513 human SP1 6667 P08047 SP1 human S702 5262508 FMRsDHLskHIKtHQ zf-C2H2 X -PRKCZ PKCZ Q05513 human Vimentin 7431 P08670 VIM human S56 451514 srsLyAssPGGVyAt Filament_head X 3877; 7391 - PKCE no information TRPV1 83810 O35433 Trpv1 rat T704 487542 WKLQRAItILDTEKS X - PKCE no information ZO2 403854 Q95168 TJP2 dog S369 9730701 QLVVLRDsKQTLINI X - PKCE no information TRPV1 83810 O35433 Trpv1 rat S502 450016 YFLQRRPsLKSLFVD Ion_trans X -WEE1 Wee1 P30291 human CDK1 54237 P39951 Cdk1 rat Y15 447610 EKIGEGtyGVVyKGR Pkinase X 4539; 9111; 14566; 77897 -WEE1 Wee1 P30291 human HSP90A 3320 P07900 HSP90AA1 human Y38 15229603 SLIINtFySNkEIFL X -WEE1 Wee1 P30291 human CDK2 1017 P24941 CDK2 human Y15 447740 EkIGEGtyGVVykAR Pkinase X -WEE1 Wee1 P30291 human CDK1 12534 P11440 Cdk1 mouse Y15 447610 EKIGEGtyGVVyKGR Pkinase X 4539; 9111; 14566; 77897 -WEE1 Wee1 P30291 human CDK1 983 P06493 CDK1 human Y15 447610 EkIGEGtyGVVykGR Pkinase X X 4539; 9111; 14566; 77897 -WEE1 Wee1 P30291 human ERG 2078 P11308 ERG human Y183 1870421702 FQRLtPSyNADILLS SAM_PNT X X -PLK3 PLK3 Q9H4B4 human ATF-2 1386 P15336 ATF2 human T69 448224 sVIVADQtPtPtRFL X 9225; 94125; 40749; 61584; 44167 -PLK3 PLK3 Q9H4B4 human 14-3-3 epsilon 7531 P62258 YWHAE human T208 14569209 DAIAELDtLsEEsyk 14-3-3 X -PLK3 PLK3 Q9H4B4 human ATF-2 1386 P15336 ATF2 human T71 448225 IVADQtPtPtRFLkN X 9225; 9221; 5112; 94125; 13850; 40749; 15411; 24329; 61584; 27934; 92109; 20534; 35858 -PLK3 PLK3 Q9H4B4 human TOP2A 7153 P11388 TOP2A human T1343 448763 FsDFDEKtDDEDFVP X X -PLK3 PLK3 Q9H4B4 human CALU 813 O43852 CALU human S44 4274908 kVHNDAQsFDyDHDA X -PLK3 PLK3 Q9H4B4 human Chk2 11200 O96017 CHEK2 human S62 3793200 sSSGTLSsLEtVstQ X -PLK3 PLK3 Q9H4B4 human HSP90B 3326 P08238 HSP90AB1 human S718 3177650 LEGDEDAsRMEEVD_ X -PLK3 PLK3 Q9H4B4 human NFL 18039 P08551 Nefl mouse S473 450895 EAKDEPPsEGEAEEE X -PLK3 PLK3 Q9H4B4 human CALU 813 O43852 CALU human T254 25688703 GkMDKEEtkDWILPs X -PLK3 PLK3 Q9H4B4 human CALU 813 O43852 CALU human T60 25688700 LGAEEAktFDQLtPE X -PLK3 PLK3 Q9H4B4 human PTEN 5728 P60484 PTEN human S370 448649 TSVtPDVsDNEPDHy X -PLK3 PLK3 Q9H4B4 human CDC25C 995 P30307 CDC25C human S191 450979 EDQAEEIsDELMEFs M-inducer_phosp X -PLK3 PLK3 Q9H4B4 human SNCB 6620 Q16143 SNCB human S118 448525 LMEPEGEsYEDPPQE Synuclein X X -PLK3 PLK3 Q9H4B4 human Bcl-xL 598 Q07817 BCL2L1 human S49 21336504 ESEMEtPsAINGNPS X X -PLK3 PLK3 Q9H4B4 human SNCA 6622 P37840 SNCA human S129 448278 NEAyEMPsEEGyQDy Synuclein X X 23706; 87281 -PLK3 PLK3 Q9H4B4 human HIF1A 3091 Q16665 HIF1A human S657 17331802 EttsATssPYRDTQS X X -PLK3 PLK3 Q9H4B4 human SNCA 20617 O55042 Snca mouse S129 448278 SEAyEMPsEEGYQDY Synuclein X 23706; 87281 -PLK3 PLK3 Q9H4B4 human Chk2 11200 O96017 CHEK2 human S73 2251701 VstQELYsIPEDQEP X -PLK3 PLK3 Q9H4B4 human PTEN 5728 P60484 PTEN human T366 449634 ASSsTSVtPDVsDNE X -PLK3 PLK3 Q9H4B4 human CALU 813 O43852 CALU human T196 25688702 KDIVVQEtMEDIDKN EF-hand_5 X -PLK3 PLK3 Q9H4B4 human NPM1 4869 P06748 NPM1 human S4 452023 ____MEDsMDMDMsP X 3520 -PLK3 PLK3 Q9H4B4 human CDC25C 995 P30307 CDC25C human S198 448636 sDELMEFsLKDQEAK M-inducer_phosp X 9529 -PLK3 PLK3 Q9H4B4 human Jun 3725 P05412 JUN human S73 447943 VGLLkLAsPELERLI Jun X 9164; 3270; 8752; 12714; 77955 -PLK3 PLK3 Q9H4B4 human p53 7157 P04637 TP53 human S20 447529 PLsQEtFsDLWkLLP P53_TAD X X 9287 -PLK3 PLK3 Q9H4B4 human CCNB1 891 P14635 CCNB1 human S133 448445 sPsPMETsGCAPAEE X 4133 -PLK3 PLK3 Q9H4B4 human Jun 3725 P05412 JUN human S63 447686 kNsDLLtsPDVGLLk Jun X 5464; 9261; 2361; 97721; 91952 -PLK3 PLK3 Q9H4B4 human CASP8 841 Q14790 CASP8 human T273 56640300 DAGALTTtFEELHFE Peptidase_C14 X X -PLK3 PLK3 Q9H4B4 human VRK1 7443 Q99986 VRK1 human S342 5938010 DDGkLDLsVVENGGL X X -PLK3 PLK3 Q9H4B4 human CDC25A 993 P30304 CDC25A human T80 4209300 RMGssEstDsGFCLD X X -PLK3 PLK3 Q9H4B4 human occludin 100506658 Q16625 OCLN human S471 6094301 LDDyREEsEEyMAAA Occludin_ELL X -PLK3 PLK3 Q9H4B4 human HIF1A 3091 Q16665 HIF1A human S576 17331801 DDDFQLRsFDQLSPL HIF-1 X X -PLK3 PLK3 Q9H4B4 human CALU 813 O43852 CALU human T177 25688701 IATkEEFtAFLHPEE X -CDK13 CDK13 Q14004 human SERINC5 256987 Q86VE9 SERINC5 human S360 1874340202 ARCCFCFsPGGEDTE Serinc X X -CDK13 CDK13 Q14004 human 4E-BP1 1978 Q13541 EIF4EBP1 human S65 447527 FLMECrNsPVtktPP eIF_4EBP X 9451; 9456; 13443 -CDK13 CDK13 Q14004 human EIF4B 1975 P23588 EIF4B human S406 470374 RPRERHPsWRsEEtQ X X 8151; 5399 -CDK13 CDK13 Q14004 human POLR2A 5430 P24928 POLR2A human S1616 450204 TPQSPSysPtsPsYS RNA_pol_Rpb1_R X 4735; 13499; 13546; 31262 -CDK13 CDK13 Q14004 human 4E-BP1 1978 Q13541 EIF4EBP1 human T70 447528 rNsPVtktPPRDLPt eIF_4EBP X 9455; 13396 -CDK13 CDK13 Q14004 human POLR2A 5430 P24928 POLR2A human S1619 447616 SPSysPtsPsYSPTS RNA_pol_Rpb1_R X 4735; 13523; 13546; 67221 -CDK13 CDK13 Q14004 human 4E-BP1 1978 Q13541 EIF4EBP1 human T46 447496 GGtLFsttPGGtRII eIF_4EBP X X 2855; 9459; 2846; 4923; 5123; 3929; 7547; 45613; 39788 -CDK13 CDK13 Q14004 human EIF4B 1975 P23588 EIF4B human S422 451290 RERsRtGsEssQtGt X 3591 -MAPK10 JNK3 P53779 human APP iso4 351 P05067-4 APP human T668 448523 VEVDAAVtPEERHLs APP_amyloid X X -MAPK10 JNK3 P53779 human DRPLA 1822 P54259 ATN1 human S739 450317 EEyETPEsPVPPARs Atrophin-1 X -MAPK10 JNK3 P53779 human GR 24413 P06536 Nr3c1 rat S246 451796 LIDENLLsPLAGEDD GCR X 97285 -MAPK10 JNK3 P53779 human BID 637 P55957 BID human T59 448406 EGyDELQtDGNRsSH BID X -MAPK10 JNK3 P53779 human Myc 4609 P01106 MYC human T73 448496 kkFELLPtPPLsPsR Myc_N X 46650 -MAPK10 JNK3 P53779 human OSBP2 23762 Q969R2 OSBP2 human S762 11171320 ECSKVMHssPssPsS Oxysterol_BP X -MAPK10 JNK3 P53779 human p21Cip1 1026 P38936 CDKN1A human S98 478193 GGRRPGTsPALLQGT X -MAPK10 JNK3 P53779 human OSBP2 23762 Q969R2 OSBP2 human S766 15721694 VMHssPssPsSDGKQ Oxysterol_BP X -MAPK10 JNK3 P53779 human BIM 12125 O54918 Bcl2l11 mouse S65 449330 GPLAPPAsPGPFATR X 4581; 4585 -MAPK10 JNK3 P53779 human Myc 4609 P01106 MYC human S86 449991 sRRsGLCsPSyVAVt Myc_N X -MAPK10 JNK3 P53779 human p21Cip1 1026 P38936 CDKN1A human S130 455618 sGEQAEGsPGGPGDs X -MAPK10 JNK3 P53779 human CBX7 52609 Q8VDS3 Cbx7 mouse T119 29669800 TNGPPPWtPTLPSSE CBX7_C X -MAPK10 JNK3 P53779 human STMN1 16765 P54227 Stmn1 mouse S38 448556 sVPdFPLsPPKKKDL Stathmin X 3426; 4191 -MAPK10 JNK3 P53779 human MCL1 17210 P97287 Mcl1 mouse S102 1172400 SAAAAIVsPEEELDG X -MAPK10 JNK3 P53779 human MCL1 17210 P97287 Mcl1 mouse T144 455375 ADGsLPStPPPPEEE X 4579 -MAPK10 JNK3 P53779 human SHC1 20416 P98083 Shc1 mouse S36 448508 TPPEELPsPSASSLG X -MAPK10 JNK3 P53779 human OSBP2 23762 Q969R2 OSBP2 human S768 15721697 HssPssPsSDGKQKT Oxysterol_BP X -MAPK10 JNK3 P53779 human Myc 4609 P01106 MYC human S77 448586 LLPtPPLsPsRRsGL Myc_N X 13748 -MAPK10 JNK3 P53779 human KIF5C 16574 P28738 Kif5c mouse S176 54436200 CTERFVSsPEEVMDV Kinesin X -MAPK10 JNK3 P53779 human STMN1 16765 P54227 Stmn1 mouse S25 448555 QAFELILsPRskEsV Stathmin X -MAPK10 JNK3 P53779 human NFAT2 4772 O95644 NFATC1 human S172 465577 YRDPsCLsPASSLSS X -MAPK10 JNK3 P53779 human OSBP2 23762 Q969R2 OSBP2 human S763 31727226 CSKVMHssPssPsSD Oxysterol_BP X -MAPK10 JNK3 P53779 human KIF5B 16573 Q61768 Kif5b mouse S175 29603400 CTERFVCsPDEVMDT Kinesin X -MAPK10 JNK3 P53779 human APLP2 334 Q06481 APLP2 human T736 451599 VEVDPMLtPEERHLN APP_amyloid X -NEK1 NEK1 Q96PY6 human TAZ 97064 Q9EPK5 Wwtr1 mouse S309 6145195 sREQSTDsGLGLGCy X X -NEK1 NEK1 Q96PY6 human ME1 4199 P48163 ME1 human S336 4701731 KKIWLVDskGLIVKG Malic_M X -NEK1 NEK1 Q96PY6 human VHL 7428 P40337 VHL human T105 23072361 YPtLPPGtGRRIHsy VHL X -NEK1 NEK1 Q96PY6 human RAD54L 8438 Q92698 RAD54L human S572 56589700 PDFVFMLsSKAGGCG Helicase_C X X -NEK1 NEK1 Q96PY6 human VHL 7428 P40337 VHL human T202 27434503 QkDLERLtQERIAHQ VHL_C X -NEK1 NEK1 Q96PY6 human VHL 7428 P40337 VHL human Y112 27434505 tGRRIHsyRGHLWLF VHL X -NEK1 NEK1 Q96PY6 human VHL 7428 P40337 VHL human S183 15227904 RRLDIVRsLyEDLED VHL_C X -NEK1 NEK1 Q96PY6 human VDAC1 7416 P21796 VDAC1 human S193 6406004 DGtEFGGsIyQkVNK Porin_3; TM X X -NEK1 NEK1 Q96PY6 human VHL 7428 P40337 VHL human Y175 27434504 sLVkPENyRRLDIVR VHL_C X -NEK1 NEK1 Q96PY6 human VHL 7428 P40337 VHL human S168 27434501 RCLQVVRsLVkPENy VHL_C X -NEK1 NEK1 Q96PY6 human VHL 7428 P40337 VHL human T100 27434502 GEPQPYPtLPPGtGR VHL X -NEK1 NEK1 Q96PY6 human HEC1 10403 O14777 NDC80 human S165 449867 LGYPFALsKSSMYTV Ndc80_HEC X -JMJD6 JMJD6 Q6NYC1 human H2AX 3014 P16104 H2AX human Y39 462307 RLLRkGHyAERVGAG Histone X X -CDK20 CDK20 Q8IZL9 human ICK 22858 Q9UPZ9 CILK1 human T157 456051 IRSKPPytDyVSTRW Pkinase X X -CDK20 CDK20 Q8IZL9 human CDK2 1017 P24941 CDK2 human T160 447739 GVPVRtytHEVVtLW Pkinase X X 2561 -Mapk3 ERK1 P21708 rat STMN2 84510 P21818 Stmn2 rat S62 450174 ELILKPPsPISEAPR Stathmin X -Mapk3 ERK1 P21708 rat p90RSK 6195 Q15418 RPS6KA1 human T573 447993 AENGLLMtPCytANF Pkinase X 9346 -Mapk3 ERK1 P21708 rat GJA1 24392 P08050 Gja1 rat S282 448854 TAPLsPMsPPGYkLV X X -Mapk3 ERK1 P21708 rat NSMF 117536 Q9EPI6 Nsmf rat S180 27713502 AKLVPGPsPRAFGLE X -Mapk3 ERK1 P21708 rat HSL 25330 P15304 Lipe rat S900 450193 GNSEPSDsPEMSQsM X -Mapk3 ERK1 P21708 rat ATP1A1 24211 P06685 Atp1a1 rat S16 449086 KyEPAAVsEHGDkks X X 4020 -Mapk3 ERK1 P21708 rat MAP2 iso2 25595 P15146-2 Map2 rat S136 448323 ETVNLPPsPPPSPAS X 4541 -Mapk3 ERK1 P21708 rat TRPV2 29465 Q9WUD2 Trpv2 rat S6 29631548 __MTSASsPPAFRLE X -Mapk3 ERK1 P21708 rat TRPV2 29465 Q9WUD2 Trpv2 rat S47 12738661 QREDRNSsPQIKVNL X -Mapk3 ERK1 P21708 rat NuMA-1 308870 F1LW91 Numa1 rat S1723 453119 SVPGEPAsPIsQRLP X -Mapk3 ERK1 P21708 rat HMG20A 315689 D3Z937 Hmg20a rat S105 469654 RDSNAPKsPLTGYVR HMG_box X -Mapk3 ERK1 P21708 rat AML1 861 Q01196 RUNX1 human S266 454400 QYLGsIAsPsVHPAt X X -Mapk3 ERK1 P21708 rat JunB 24517 P24898 Junb rat S256 452631 RDAtPPVsPINMEDQ X -Mapk3 ERK1 P21708 rat Fos 314322 P12841 Fos rat T331 448484 CtPVVTCtPSCTTYT X -Mapk3 ERK1 P21708 rat SYN1 24949 P09951 Syn1 rat S62 451572 stAAPVAsPAAPsPG X -Mapk3 ERK1 P21708 rat CAD 101843763 P08955 Cad hamster T456 451248 KVYFLPItPHYVTQV X -Mapk3 ERK1 P21708 rat ELK1 314436 A4GTP4 Elk1 rat S382 447872 IHFWSTLsPIAPRSP X -Mapk3 ERK1 P21708 rat DUSP6 116663 Q64346 Dusp6 rat S197 455266 SATDSDGsPLSNSQP X -Mapk3 ERK1 P21708 rat SYN1 24949 P09951 Syn1 rat S549 451574 PAARPPAsPsPQRQA X -Mapk3 ERK1 P21708 rat LIFR 3977 P42702 LIFR human S1044 450385 WNLVsPDsPRsIDSN X -Mapk3 ERK1 P21708 rat PTP-SL iso2 19279 Q62132-2 Ptprr mouse T253 450119 EPFVAVStPREKVAM X -Mapk3 ERK1 P21708 rat MAP2 25595 P15146 Map2 rat S136 448323 ETVNLPPsPPPsPAS X 4541 -Mapk3 ERK1 P21708 rat Fos 314322 P12841 Fos rat S374 448482 PSSDSLSsPTLLAL_ X -Mapk3 ERK1 P21708 rat GJA1 24392 P08050 Gja1 rat S279 448853 SSPTAPLsPMsPPGY X X -Mapk3 ERK1 P21708 rat SP1 6667 P08047 SP1 human T739 448227 sEGSGtAtPSALITT X -Mapk3 ERK1 P21708 rat ENaC-gamma 24768 P37091 Scnn1g rat T623 451220 PGSTVPGtPPPRYNT X -Mapk3 ERK1 P21708 rat SYN1 24949 P09951 Syn1 rat S67 451573 VAsPAAPsPGSSGGG X -Mapk3 ERK1 P21708 rat UBF 25574 P25977 Ubtf rat T117 448504 DFPKKPLtPYFRFFM HMG_box X X -Mapk3 ERK1 P21708 rat ERK1 50689 P21708 Mapk3 rat T208 3949243 FLtEyVAtRWYRAPE Pkinase X X -Mapk3 ERK1 P21708 rat Bcl-2 24224 P49950 Bcl2 rat S70 448395 RDTAARTsPLRPLVA X -Mapk3 ERK1 P21708 rat TRPV2 29465 Q9WUD2 Trpv2 rat S37 8110156 QEPPPMEsPFQREDR X -Mapk3 ERK1 P21708 rat AML1 861 Q01196 RUNX1 human S249 454399 DTRQIQPsPPWsyDQ X X 4327 -Mapk3 ERK1 P21708 rat GJA1 24392 P08050 Gja1 rat S255 448852 HATTGPLsPskDCGs X -Mapk3 ERK1 P21708 rat SMAD3 4088 P84022 SMAD3 human S208 451179 DAGsPNLsPNPMsPA X -Mapk3 ERK1 P21708 rat ENaC-beta 24767 P37090 Scnn1b rat T613 451219 QTLPIPGtPPPNYDS X -Mapk3 ERK1 P21708 rat STMN2 84510 P21818 Stmn2 rat S73 450173 EAPRTLAsPKKkDLs Stathmin X -Mapk3 ERK1 P21708 rat DDX47 297685 G3V727 Ddx47 rat S9 9765795 AADEEPDsPtEALQT X -Mapk3 ERK1 P21708 rat JunD 24518 P52909 Jund rat S100 456168 LGLLKLAsPELERLI Jun X 9164 -Mapk3 ERK1 P21708 rat gephyrin 64845 Q03555 Gphn rat S281 483463 AsLSttPsEsPRAQA X -Mapk3 ERK1 P21708 rat Caldesmon 25687 Q62736 Cald1 rat S527 448466 QSVDKVTsPTKV___ X -Mapk3 ERK1 P21708 rat ZO1 292994 A0A0G2K2P5 Tjp1 rat S402 28100900 PDVDLPVsPSDGVLP X -Mapk3 ERK1 P21708 rat Myc 4609 P01106 MYC human S77 448586 LLPtPPLsPsRRsGL Myc_N X 13748 -Mapk3 ERK1 P21708 rat MAP2 iso3 25595 P15146-3 Map2 rat S136 448323 ETVNLPPsPPPSPAS X 4541 -Mapk3 ERK1 P21708 rat MAP2 25595 P15146 Map2 rat T1622 450181 YSSRtPGtPGtPSyP X 4544 -Mapk3 ERK1 P21708 rat SP1 6667 P08047 SP1 human T453 448226 SGPIIIRtPTVGPNG X -Mapk3 ERK1 P21708 rat EFNB3 360546 G3V7D4-1 Efnb3 rat S332 27722391 VQDGPPQsPPNIYYK X -Mapk3 ERK1 P21708 rat TRPV2 29465 Q9WUD2 Trpv2 rat S760 7103644 LPLQVLQsP______ X -Mapk3 ERK1 P21708 rat MEK2 58960 P36506 Map2k2 rat S295 3822601 DGEPHSVsPRPRPPG Pkinase X -Mapk3 ERK1 P21708 rat UBF 25574 P25977 Ubtf rat T201 448505 DIPEKPKtPQQLWYT HMG_box X X -Mapk3 ERK1 P21708 rat TH 25085 P04177 Th rat S31 448544 KQAEAVtsPRFIGRR TOH_N X X 3370; 13041 -Mapk3 ERK1 P21708 rat GRASP65 56082 O35254 Gorasp1 rat S277 455582 EQLPGPGsPGHGTAD X -Mapk3 ERK1 P21708 rat MAP2 25595 P15146 Map2 rat T1625 450182 RtPGtPGtPSyPRTP X 4544 -Mapk3 ERK1 P21708 rat Jun 24516 P17325 Jun rat S246 450451 PGETPPLsPIDMESQ X 2994 -Mknk1 Mnk1 O08605 mouse EIF4E 13684 P63073 Eif4e mouse S209 447776 DTATKSGsttKNRFV X 9741 -Mknk1 Mnk1 O08605 mouse PLA2G4A 18783 P47713 Pla2g4a mouse S726 447599 RQNPsRCsVsLsNVE X X -Mknk1 Mnk1 O08605 mouse EIF4E 1977 P06730 EIF4E human S209 447776 DtATksGsttKNRFV X X 9741 -CSNK1G3 CK1G3 Q9Y6M4 human SNCA 6622 P37840 SNCA human T64 1876998407 EktkEQVtNVGGAVV Synuclein X -CSNK1G3 CK1G3 Q9Y6M4 human LRP6 4040 O75581 LRP6 human T1479 457635 SSsstKGtyFPAILN X -CSNK1G3 CK1G3 Q9Y6M4 human SNCA 20617 O55042 Snca mouse T64 1876998407 EKtKEQVtNVGGAVV Synuclein X -CSNK1G3 CK1G3 Q9Y6M4 human LRP6 4040 O75581 LRP6 human S1490 456289 AILNPPPsPAtERsH X 2568 -CSNK1G3 CK1G3 Q9Y6M4 human LYN 4067 P07948 LYN human S13 1983291 SKGkDsLsDDGVDLk X -Camk1 CAMK1A Q63450 rat NUMB 8650 P49757 NUMB human S276 456490 EQLARQGsFrGFPAL NumbF X X 4140; 9878 -Camk1 CAMK1A Q63450 rat SYN1 24949 P09951 Syn1 rat S9 448378 NYLRRRLsDSNFMAN Synapsin_N X 2311; 67605 -Camk1 CAMK1A Q63450 rat CREB iso1 81646 P15337-1 Creb1 rat S133 448228 EILsRRPsYRkILND pKID X 9187; 9196; 9198; 4095; 14228; 14001; 39561; 80120; 44864; 54960; 95995 -Camk1 CAMK1A Q63450 rat nNOS 24598 P29476 Nos1 rat S741 452159 LAEAVkFsAkLMGQA X X -Camk1 CAMK1A Q63450 rat K18 3875 P05783 KRT18 human S53 447734 IsVsrstsFrGGMGs X -Camk1 CAMK1A Q63450 rat MRLC1 10398 P24844 MYL9 human S20 1863500 KRPQRAtsNVFAMFD X 3674; 3671; 3675; 95777 -Camk1 CAMK1A Q63450 rat HMGCR 25675 P51639 Hmgcr rat S871 448568 SHMVHNRsKINLQDL X -Camk1 CAMK1A Q63450 rat CAMKK1 60341 P97756 Camkk1 rat T108 452083 PRAWRRPtIESHHVA X -Camk1 CAMK1A Q63450 rat SYN1 281510 P17599 SYN1 cow S9 448378 NYLRRRLsDSNFMAN Synapsin_N X -Camk1 CAMK1A Q63450 rat NUMBL 292732 A1L1I3 Numbl rat S305 456489 EQLVRQGsFRGFPAL NumbF X X -Prkch PKCH P23298 mouse PRKD1 18760 Q62101 Prkd1 mouse S744 448589 ARIIGEksFRRsVVG Pkinase X 2054 -Prkch PKCH P23298 mouse PRKD1 85421 Q9WTQ1 Prkd1 rat S748 448590 GEKsFRRsVVGTPAY Pkinase X -Prkch PKCH P23298 mouse PRKD1 18760 Q62101 Prkd1 mouse S748 448590 GEksFRRsVVGtPAy Pkinase X 2054 -Prkch PKCH P23298 mouse PRKD1 85421 Q9WTQ1 Prkd1 rat S744 448589 ARIIGEKsFRRsVVG Pkinase X -AXL AXL P30530 human MLKL 197259 Q8NB16 MLKL human Y376 1868624704 DRVkstAyLSPQELE PK_Tyr_Ser-Thr X -AXL AXL P30530 human ELMO2 63916 Q96JJ3 ELMO2 human Y713 477009 IPKEPssyDFVyHyG X -AXL AXL P30530 human Akt1 207 P31749 AKT1 human S473 447855 RPHFPQFsysAsGtA Pkinase_C X 9271; 3787; 4060; 4051; 5102; 4058; 2336; 2337; 4075; 4070; 5012; 4071; 92982; 5315; 9563; 9018; 12694; 52240; 11962; 15116; 88106; 26580; 68035; 31957; 23430; 20235 -AXL AXL P30530 human STAT5A 6776 P42229 STAT5A human Y694 447767 LAkAVDGyVkPQIkQ X 9365; 9356; 9359; 9351; 4322; 9314; 3939; 40284; 5387; 14603; 66740; 51879; 72712 -AXL AXL P30530 human ELMO1 9844 Q92556 ELMO1 human Y724 455566 PsNyDFVyDCN____ X -AXL AXL P30530 human STAT3 6774 P40763 STAT3 human Y705 448192 DPGsAAPyLktKFIC X 4093; 9145; 4324; 9131; 9138; 4323; 4074; 4113; 48313; 20977; 25023; 8119; 52075; 52527; 73533; 61958; 73452; 16185; 74309 -AXL AXL P30530 human Lck 3932 P06239 LCK human Y394 447822 RLIEDNEytAREGAk PK_Tyr_Ser-Thr X 2101; 6943; 59548; 70926; 78740; 94361; 17320 -AXL AXL P30530 human Fyn 2534 P06241 FYN human Y420 447882 RLIEDNEytARQGAk PK_Tyr_Ser-Thr X 2101; 6943; 59548; 70926; 78740; 94361; 17320 -AXL AXL P30530 human ELMO1 9844 Q92556 ELMO1 human Y720 455565 IPKEPsNyDFVyDCN X X -AXL AXL P30530 human LYN 4067 P07948 LYN human Y397 448695 RVIEDNEytAREGAk PK_Tyr_Ser-Thr X 2101; 6943; 59548; 70926; 78740; 94361; 17320 -AXL AXL P30530 human Hck 3055 P08631 HCK human Y411 448168 RVIEDNEytAREGAk PK_Tyr_Ser-Thr X 2101; 6943; 59548; 70926; 78740; 94361; 17320 -AXL AXL P30530 human STAT5B 6777 P51692 STAT5B human Y699 448198 tAkAVDGyVkPQIkQ X 9365; 9356; 9359; 9351; 4322; 9314; 3939; 40284; 5387; 14603; 66740; 51879; 72712 -AXL AXL P30530 human Src 6714 P12931 SRC human Y419 448234 RLIEDNEytARQGAk PK_Tyr_Ser-Thr X 2101; 6943; 59548; 70926; 78740; 94361; 17320 -AXL AXL P30530 human Yes 7525 P07947 YES1 human Y426 447619 RLIEDNEytARQGAk PK_Tyr_Ser-Thr X 2101; 6943; 59548; 70926; 78740; 94361; 17320 -AXL AXL P30530 human Akt1 207 P31749 AKT1 human T308 447856 kDGAtMKtFCGtPEy Pkinase X 5106; 2965; 9275; 4056; 5056; 13842; 13038; 43506; 48646; 86758; 80722; 77440; 80556 -Plk2 PLK2 P53351 mouse SNCA 6622 P37840 SNCA human S129 448278 NEAyEMPsEEGyQDy Synuclein X 23706; 87281 -Plk2 PLK2 P53351 mouse SNCA 20617 O55042 Snca mouse S129 448278 SEAyEMPsEEGYQDY Synuclein X 23706; 87281 -Fgfr2 FGFR2 P21803 mouse PLCG1 18803 Q62077 Plcg1 mouse Y771 448575 IGTAEPDyGALyEGR X -DAPK3 DAPK3 O43293 human PPP1R14A 94274 Q96A00 PPP1R14A human S12 10294800 rLGKRVLsKLQsPSr PP1_inhibitor X -DAPK3 DAPK3 O43293 human DAPK3 1613 O43293 DAPK3 human T306 454894 tTRLkEytIksHssL X -DAPK3 DAPK3 O43293 human DAPK3 1613 O43293 DAPK3 human S311 454895 EytIksHssLPPNNS X -DAPK3 DAPK3 O43293 human MRLC1 296313 Q64122 Myl9 rat S20 1863500 KRPQSAtsNVFAMFD X 3674; 3671; 3675; 95777 -DAPK3 DAPK3 O43293 human LMO7 iso3 4008 Q8WWI1-3 LMO7 human S863 478135 LKNLKRRsQFFEQGS X X -DAPK3 DAPK3 O43293 human MRLC1 10398 P24844 MYL9 human T19 1863501 KKRPQRAtsNVFAMF X 3674; 95777 -DAPK3 DAPK3 O43293 human PPP1R14A 94274 Q96A00 PPP1R14A human T38 449098 QkRHARVtVkYDRRE PP1_inhibitor X -DAPK3 DAPK3 O43293 human MDM2 4193 Q00987 MDM2 human S186 448131 RQRkRHksDsIsLsF X -DAPK3 DAPK3 O43293 human MRLC1 296313 Q64122 Myl9 rat T19 1863501 KKRPQSAtsNVFAMF X 3674; 95777 -DAPK3 DAPK3 O43293 human p21Cip1 1026 P38936 CDKN1A human T145 447837 QGRkRRQtsMTDFyH X X -DAPK3 DAPK3 O43293 human beclin 1 8678 Q14457 BECN1 human S90 472001 IPPARMMstEsANsF X X 29362; 86455 -DAPK3 DAPK3 O43293 human TRIP12 9320 Q14669 TRIP12 human S312 452826 STKkRsEsPPAELPs X -DAPK3 DAPK3 O43293 human MYPT1 396020 Q90623 PPP1R12A chicken T695 448587 ARQSRRstQGVTLTD X X 5163 -DAPK3 DAPK3 O43293 human MDM2 4193 Q00987 MDM2 human S166 448130 SsRRRAIsEtEENsD X 3521 -DAPK3 DAPK3 O43293 human RPL13A 23521 P40429 RPL13A human S77 5594501 PYHFrAPsRIFWRTV Ribosomal_L13 X X -DAPK3 DAPK3 O43293 human MRLC2 103910 O14950 MYL12B human S20 448595 KRPQRAtsNVFAMFD X X -DAPK3 DAPK3 O43293 human p53 7157 P04637 TP53 human S20 447529 PLsQEtFsDLWkLLP P53_TAD X 9287 -DAPK3 DAPK3 O43293 human DAPK3 1613 O43293 DAPK3 human T180 454890 EFKNIFGtPEFVAPE Pkinase X -DAPK3 DAPK3 O43293 human MRLC1 10398 P24844 MYL9 human S20 1863500 KRPQRAtsNVFAMFD X 3674; 3671; 3675; 95777 -DAPK3 DAPK3 O43293 human MRLC1 98932 Q9CQ19 Myl9 mouse S20 1863500 KRPQRAtsNVFAMFD X X 3674; 3671; 3675; 95777 -DAPK3 DAPK3 O43293 human MRLC1 98932 Q9CQ19 Myl9 mouse T19 1863501 KKRPQRAtsNVFAMF X X 3674; 95777 -DAPK3 DAPK3 O43293 human DAPK3 1613 O43293 DAPK3 human T225 454891 LGETKQEtLTNISAV Pkinase X -DAPK3 DAPK3 O43293 human MYPT1 396020 Q90623 PPP1R12A chicken S849 451999 RPREKRRstGVSFWT X -DAPK3 DAPK3 O43293 human DAPK3 1613 O43293 DAPK3 human T265 454892 KDPKRRMtIAQSLEH Pkinase X -DAPK3 DAPK3 O43293 human MRLC2 103910 O14950 MYL12B human T19 448596 KKRPQRAtsNVFAMF X X -DAPK3 DAPK3 O43293 human CDC14A 8556 Q9UNH5 CDC14A human S484 31085757 INSRLASsLGNLNAA X -DAPK3 DAPK3 O43293 human DAPK3 1613 O43293 DAPK3 human T299 454893 PERRRLKtTRLkEyt X -DAPK3 DAPK3 O43293 human MYPT1 396020 Q90623 PPP1R12A chicken T716 3078001 tIGRSRStRTREQEN X - P38A no information Tip60 10524 Q92993 KAT5 human T158 10800707 VEVVsPAtPVPSETA X -FGFR2 FGFR2 P21802 human FGFR2 2263 P21802 FGFR2 human Y769 448113 TLTTNEEyLDLSQPL X -FGFR2 FGFR2 P21802 human CTNNB1 1499 P35222 CTNNB1 human Y142 449044 AVVNLINyQDDAELA X X -FGFR2 FGFR2 P21802 human ephexin-1 53972 Q8CHT1 Ngef mouse Y177 455579 IEQIGLLyQEyRDKS X -FGFR2 FGFR2 P21802 human PTEN 5728 P60484 PTEN human Y240 448316 RREDKFMyFEFPQPL PTEN_C2 X X -FGFR2 FGFR2 P21802 human GLO1 2739 Q04760 GLO1 human Y136 463450 GIAVPDVysACkRFE Glyoxalase X -FGFR2 FGFR2 P21802 human PIGL 9487 Q9Y2B2 PIGL human Y81 1881980200 LCFSAGNyYNQGETR X X -FGFR2 FGFR2 P21802 human TfR 7037 P02786 TFRC human Y20 448928 FGGEPLsytRFsLAR X -FGFR2 FGFR2 P21802 human GRB2 2885 P62993 GRB2 human Y160 452038 QVPQQPtyVQALFDF X -BRSK1 BRSK1 iso2 Q8TDC3-2 human AMPKA1 5562 Q13131 PRKAA1 human T183 448786 sDGEFLRtsCGsPNy Pkinase X 2535; 2531; 4188; 5256; 50081; 74281 -BRSK1 BRSK1 iso2 Q8TDC3-2 human CDC25B 994 P30305 CDC25B human S375 455380 ARVLRsksLCHDEIE M-inducer_phosp X -BRSK1 BRSK1 iso2 Q8TDC3-2 human CDC25C 995 P30307 CDC25C human S216 448418 sGLyRsPsMPENLNR M-inducer_phosp X X 9528; 4901; 30790 -BRSK1 BRSK1 iso2 Q8TDC3-2 human BRSK1 iso2 84446 Q8TDC3-2 BRSK1 human T205 456027 VGDSLLEtSCGsPHY Pkinase X -BRSK1 BRSK1 iso2 Q8TDC3-2 human Wee1 7465 P30291 WEE1 human S642 455381 KKMNRSVsLtIy___ X 4910 -BRSK1 BRSK1 iso2 Q8TDC3-2 human TUBG1 7283 P23258 TUBG1 human S131 10045600 READGsDsLEGFVLC Tubulin X X -BRSK1 BRSK1 iso2 Q8TDC3-2 human Tau 29477 P19332 Mapt rat S573 447930 NVRSKIGsTENLKHQ Tubulin-binding X -BRSK1 BRSK1 iso2 Q8TDC3-2 human BRSK1 iso2 84446 Q8TDC3-2 BRSK1 human S209 464650 LLEtSCGsPHYACPE Pkinase X -TNK2 Ack Q07912 human N-WASP 682507 O08816 Wasl rat S239 457322 LFDMCGIsEAQLKDR PBD X X -TNK2 Ack Q07912 human CSK 12988 P41241 Csk mouse Y18 41510404 GTECIAKyNFHGTAE SH3_1 X -TNK2 Ack Q07912 human AR 367 P10275 AR human Y365 478251 AyQSRDyyNFPLALA Androgen_recep X -TNK2 Ack Q07912 human Ack 10188 Q07912 TNK2 human Y860 448884 KVsstHyyLLPERPs X -TNK2 Ack Q07912 human Akt1 207 P31749 AKT1 human S473 447855 RPHFPQFsysAsGtA Pkinase_C X 9271; 3787; 4060; 4051; 5102; 4058; 2336; 2337; 4075; 4070; 5012; 4071; 92982; 5315; 9563; 9018; 12694; 52240; 11962; 15116; 88106; 26580; 68035; 31957; 23430; 20235 -TNK2 Ack Q07912 human AR 367 P10275 AR human Y269 478250 QLRGDCMyAPLLGVP Androgen_recep X -TNK2 Ack Q07912 human Ack 10188 Q07912 TNK2 human Y284 450946 LPQNDDHyVMQEHRK PK_Tyr_Ser-Thr X 3138 -TNK2 Ack Q07912 human H4 8359 P62805 H4C1 human Y88 457867 VtAMDVVyALkRQGR CENP-T_C X X -TNK2 Ack Q07912 human PAG 94212 Q3U1F9 Pag1 mouse Y224 450995 GKADFAEyAsVDRNK PAG X -TNK2 Ack Q07912 human p27Kip1 1027 P46527 CDKN1B human Y88 456818 kGsLPEFyyRPPRPP X -TNK2 Ack Q07912 human ATP5A1 498 P25705 ATP5F1A human Y243 461991 SDEkkkLyCIyVAIG ATP-synt_ab X X -TNK2 Ack Q07912 human Ack 10188 Q07912 TNK2 human Y859 448883 KKVsstHyyLLPERP X -TNK2 Ack Q07912 human ATP5A1 498 P25705 ATP5F1A human Y246 477314 kkkLyCIyVAIGQKR ATP-synt_ab X X -TNK2 Ack Q07912 human PAG 94212 Q3U1F9 Pag1 mouse Y314 450659 EEEISAMySSVNKPG PAG X -TNK2 Ack Q07912 human WWOX 51741 Q9NZC7 WWOX human Y287 457684 LSPTKNDyWAMLAYN X -TNK2 Ack Q07912 human PAG 94212 Q3U1F9 Pag1 mouse Y414 448996 HVPKEsDyEsIGDLQ PAG X -TNK2 Ack Q07912 human Ack 51789 O54967 Tnk2 mouse Y284 450946 LPQNDDHyVMQEHRK PK_Tyr_Ser-Thr X 3138 -TNK2 Ack Q07912 human AR 367 P10275 AR human Y535 470068 MDSYSGPyGDMRLET X -TNK2 Ack Q07912 human JMJD1A 55818 Q9Y4C1 KDM3A human Y1114 35527104 ITPEDRKyGTTNLHL X -TNK2 Ack Q07912 human WASP 7454 P42768 WAS human Y291 447985 AEtsKLIyDFIEDQG PBD X -TNK2 Ack Q07912 human N-WASP 682507 O08816 Wasl rat Y253 450253 REtsKVIyDFIEKtG PBD X -Plk1 PLK1 Q62673 rat DYNC1I2 116659 Q62871 Dync1i2 rat T95 469264 PssKSVstPsEAGsQ X -AKT3 Akt3 Q9Y243 human IRF7 54123 P70434 Irf7 mouse S437 486437 SsLGLCLssTNsLYE X 24129 -AKT3 Akt3 Q9Y243 human IRF7 54123 P70434 Irf7 mouse S438 486438 sLGLCLssTNsLYED X 24129 -AKT3 Akt3 Q9Y243 human HSF1 3297 Q00613 HSF1 human S230 448072 PkYSRQFsLEHVHGS X X -AKT3 Akt3 Q9Y243 human ADAR 103 P55265 ADAR human T1033 1868546602 RLGERLRtMSCSDKI A_deamin X -AKT3 Akt3 Q9Y243 human GSK3B 56637 Q9WV60 Gsk3b mouse S9 449111 SGRPRttsFAEsCKP X 9336; 9331; 9327; 9323; 9322; 9325; 5558; 8566; 79774; 8466; 25462; 14026; 14332; 14310; 14630 -AKT3 Akt3 Q9Y243 human RED1 104 P78563 ADARB1 human T553 31884906 LQGERLLtMSCSDKI A_deamin X -AKT3 Akt3 Q9Y243 human p47phox 653361 P14598 NCF1 human S304 449406 GAPPRRssIRNAHsI NECFESHC X -AKT3 Akt3 Q9Y243 human IRF3 54131 P70671 Irf3 mouse S378 448696 MAREGGAssLKTVDL X -AKT3 Akt3 Q9Y243 human AGO2 27161 Q9UKV8 AGO2 human S387 472450 SkLMRsAsFNtDPyV ArgoL2 X X -AKT3 Akt3 Q9Y243 human TSC2 22084 Q61037 Tsc2 mouse T1465 448546 GLRPRGYtISDSAPS X 3617; 3611 -AKT3 Akt3 Q9Y243 human IWS1 55677 Q96ST2 IWS1 human T721 1851496 QRRRMNstGGQtPRR X X -AKT3 Akt3 Q9Y243 human CYCS 54205 P99999 CYCS human Y47 3416311 ktGQAPGysytAANk Cytochrom_C X -AKT3 Akt3 Q9Y243 human RENT1 5976 Q92900 UPF1 human T151 50788283 FCNGRGNtSGSHIVN UPF1_Zn_bind X -AKT3 Akt3 Q9Y243 human TBX3 6926 O15119 TBX3 human S719 23151362 AEkEAAtsELQSIQR X X -AKT3 Akt3 Q9Y243 human BRAF 673 P15056 BRAF human S365 450243 GQRDRsssAPNVHIN X X -AKT3 Akt3 Q9Y243 human RSK2 6197 P51812 RPS6KA3 human T115 1880515604 KVRDRVRtKMERDIL X -AKT3 Akt3 Q9Y243 human BRAF 673 P15056 BRAF human S429 447803 PQRERKsssssEDRN X X -AKT3 Akt3 Q9Y243 human Merlin 4771 P35240 NF2 human S10 1720901 GAIASRMsFSsLkRK X -AKT3 Akt3 Q9Y243 human p47phox 653361 P14598 NCF1 human S328 449404 QDAYRRNsVRFLQQR NECFESHC X -AKT3 Akt3 Q9Y243 human EMSY 56946 Q7Z589 EMSY human T207 1210942 KPRKRRRtNsssssP X -AKT3 Akt3 Q9Y243 human IRF3 3661 Q14653 IRF3 human S385 448696 MARVGGAssLENtVD X -AKT3 Akt3 Q9Y243 human IWS1 55677 Q96ST2 IWS1 human S720 477902 PQRRRMNstGGQtPR X X -AKT3 Akt3 Q9Y243 human EMSY 56946 Q7Z589 EMSY human S209 453526 RKRRRtNsssssPVV X -MAP3K1 MEKK1 Q13233 human MAFA 389692 Q8NHW3 MAFA human S14 1713900 MGAELPSsPLAIEYV X -MAP3K1 MEKK1 Q13233 human MKK7 5609 O14733 MAP2K7 human T275 447698 LVDsKAKtRsAGCAA Pkinase X 4171 -MAP3K1 MEKK1 Q13233 human MEK1 26395 P31938 Map2k1 mouse T292 448287 EtPPRPRtPGRPLsS Pkinase X 26975 -MAP3K1 MEKK1 Q13233 human MKK7 5609 O14733 MAP2K7 human S271 447697 IsGRLVDsKAKtRsA Pkinase X 4171 -MAP3K1 MEKK1 Q13233 human Notch 1 4851 P46531 NOTCH1 human T2511 483083 VPEHPFLtPsPEsPD X -MAP3K1 MEKK1 Q13233 human FADD 8772 Q13158 FADD human S194 447653 QNRsGAMsPMsWNsD X 2781 -MAP3K1 MEKK1 Q13233 human MAFA 389692 Q8NHW3 MAFA human S65 5403102 PCSsVPSsPSFCAPS X -MAP3K1 MEKK1 Q13233 human IKKB 3551 O14920 IKBKB human S181 447489 DQGsLCtsFVGTLQy Pkinase X 2697; 2694; 14938; 92255; 36516; 36214 -TP53RK PRPK Q96S44 human p53 7157 P04637 TP53 human S15 447490 PsVEPPLsQEtFsDL P53_TAD X X 4030; 9235; 9284; 9286; 8695; 8514; 82530; 56979 -ALK ALK Q9UM73 human ALK 238 Q9UM73 ALK human Y1604 447828 tAPGAGHyEDTILkS X 3341 -ALK ALK Q9UM73 human ELP3 55140 Q9H9T3 ELP3 human Y202 450611 GHtSNNIyEAVkySE Radical_SAM X X -ALK ALK Q9UM73 human ALK 238 Q9UM73 ALK human Y1278 450377 FGMARDIyRAsyyRK PK_Tyr_Ser-Thr X 3983; 3710; 6941 -ALK ALK Q9UM73 human CDK9 1025 P50750 CDK9 human Y19 1880104202 FCDEVSkyEkLAkIG X X -ALK ALK Q9UM73 human PSF 6421 P23246 SFPQ human Y293 482843 RRPGEktyTQRCRLF X X -ALK ALK Q9UM73 human ATIC 471 P31939 ATIC human Y104 456299 RVVACNLyPFVkTVA MGS X -ALK ALK Q9UM73 human SNIP 80725 Q9C0H9 SRCIN1 human Y396 456704 LVKGEGLyADPyGLL X -ALK ALK Q9UM73 human STAT3 6774 P40763 STAT3 human Y705 448192 DPGsAAPyLktKFIC X 4093; 9145; 4324; 9131; 9138; 4323; 4074; 4113; 48313; 20977; 25023; 8119; 52075; 52527; 73533; 61958; 73452; 16185; 74309 -ALK ALK Q9UM73 human SHP-2 5781 Q06124 PTPN11 human Y580 448493 REDsARVyENVGLMQ X 3703; 5431; 13328 -ALK ALK Q9UM73 human STAT3 20848 P42227 Stat3 mouse Y705 448192 DPGsAAPyLktkFIC X 4093; 9145; 4324; 9131; 9138; 4323; 4074; 4113; 48313; 20977; 25023; 8119; 52075; 52527; 73533; 61958; 73452; 16185; 74309 -ALK ALK Q9UM73 human PBK 55872 Q96KB5 PBK human Y74 473837 NPICNDHyRsVyQkR Pkinase X -ALK ALK Q9UM73 human VASP 7408 P50552 VASP human Y39 449577 AFSRVQIyHNPtANs WH1 X -ALK ALK Q9UM73 human SHP-2 5781 Q06124 PTPN11 human Y542 448492 sKRkGHEytNIKysL X 3751; 94740; 15543; 64117 -ALK ALK Q9UM73 human GRB2 2885 P62993 GRB2 human Y160 452038 QVPQQPtyVQALFDF X -RPS6KA5 MSK1 O75582 human 4E-BP1 13685 Q60876 Eif4ebp1 mouse S64 447527 FLMECRNsPVAKtPP eIF_4EBP X X 9451; 9456 -RPS6KA5 MSK1 O75582 human MSK1 9252 O75582 RPS6KA5 human S376 448216 EKLFQGysFVAPsIL Pkinase_C X X 9591 -RPS6KA5 MSK1 O75582 human Nur77 15370 P12813 Nr4a1 mouse S354 447942 GRRGRLPsKPKQPPD X 5095 -RPS6KA5 MSK1 O75582 human MSK1 9252 O75582 RPS6KA5 human S381 455795 GysFVAPsILFkRNA X X -RPS6KA5 MSK1 O75582 human LRRC8A 56262 Q8IWT6 LRRC8A human S217 471190 PMLQRtKsRIEQGIV Pannexin_like X -RPS6KA5 MSK1 O75582 human MSK1 9252 O75582 RPS6KA5 human S212 448214 DETERAYsFCGTIEY Pkinase X X -RPS6KA5 MSK1 O75582 human RARA 5914 P10276 RARA human S369 451381 YVRKRRPsRPHMFPK Hormone_recep X X -RPS6KA5 MSK1 O75582 human H3 8350 P68431 H3C1 human S10 455676 tkQtArkstGGkAPr Histone X X 9701; 9711; 9606; 3465; 3642; 3377; 3475; 3458; 5764; 47398; 8481; 8552; 53348; 29237; 66065; 43185; 64522; 52725 -RPS6KA5 MSK1 O75582 human H3 360198 P68433 H3c1 mouse S10 455676 tkQTARkstGGkAPr Histone X 9701; 9711; 9606; 3465; 3642; 3377; 3475; 3458; 5764; 47398; 8481; 8552; 53348; 29237; 66065; 43185; 64522; 52725 -RPS6KA5 MSK1 O75582 human SRF 6722 P11831 SRF human S103 447692 RGLKRsLsEMEIGMV X 4261 -RPS6KA5 MSK1 O75582 human CREB iso1 81646 P15337-1 Creb1 rat S133 448228 EILsRRPsYRkILND pKID X 9187; 9196; 9198; 4095; 14228; 14001; 39561; 80120; 44864; 54960; 95995 -RPS6KA5 MSK1 O75582 human H2A.1 8329 P0C0S8 H2AC17 human S1 451190 _______sGrGkQGG Histone X -RPS6KA5 MSK1 O75582 human H3 8350 P68431 H3C1 human S28 455677 ATkAArksAPATGGV Histone X X 9713 -RPS6KA5 MSK1 O75582 human MSK1 9252 O75582 RPS6KA5 human S752 455797 KMKKTstsTETRsss X X -RPS6KA5 MSK1 O75582 human TIF1B 21849 Q62318 Trim28 mouse S473 452391 SGMkRsRsGEGEVSG X X -RPS6KA5 MSK1 O75582 human CBX3 11335 Q13185 CBX3 human S93 457001 kDGtKRksLsDsEsD X X 2600 -RPS6KA5 MSK1 O75582 human BAD 12015 Q61337 Bad mouse S155 447863 GRELRRMsDEFEGsF Bcl-2_BAD X 9297 -RPS6KA5 MSK1 O75582 human 4E-BP1 13685 Q60876 Eif4ebp1 mouse T36 447497 PPGDysttPGGtLFs eIF_4EBP X 2855; 9459; 2846; 4923; 5123; 3929; 7547; 45613; 39788 -RPS6KA5 MSK1 O75582 human CREB 1385 P16220 CREB1 human S119 448228 EILsRRPsyRkILND pKID X X 9187; 9196; 9198; 4095; 14228; 14001; 39561; 80120; 44864; 54960; 95995 -RPS6KA5 MSK1 O75582 human NFkB-p65 19697 Q04207 Rela mouse S276 447798 SMQLRRPsDRELSEP RHD_dimer X -RPS6KA5 MSK1 O75582 human JMJD1A 55818 Q9Y4C1 KDM3A human S264 8100021 IGAVKRKssENNGTL X X -RPS6KA5 MSK1 O75582 human MSK1 9252 O75582 RPS6KA5 human S750 455796 RRKMKKTstsTETRs X X -RPS6KA5 MSK1 O75582 human ataxin-1 6310 P54253 ATXN1 human S775 449110 AtRKRRWsAPESRKL X X -RPS6KA5 MSK1 O75582 human ATF-1 466 P18846 ATF1 human S63 449762 GILARRPsyRKILkD pKID X X 4095; 14228; 14001 -RPS6KA5 MSK1 O75582 human NFkB-p65 5970 Q04206 RELA human S276 447798 sMQLRRPsDRELsEP RHD_dimer X X -RPS6KA5 MSK1 O75582 human WNK1 65125 Q9H4A3 WNK1 human T60 450948 EYRRRRHtMDKDSrG X 4946 -RPS6KA5 MSK1 O75582 human H3 360198 P68433 H3c1 mouse S28 455677 ATkAArksAPATGGV Histone X 9713 -RPS6KA5 MSK1 O75582 human ELK1 2002 P19419 ELK1 human S383 447872 IHFWSTLsPIAPRsP X 9181; 9186 -RPS6KA5 MSK1 O75582 human CREB 12912 Q01147 Creb1 mouse S119 448228 EILsRRPsyRkILND pKID X 9187; 9196; 9198; 4095; 14228; 14001; 39561; 80120; 44864; 54960; 95995 -RPS6KA5 MSK1 O75582 human TH iso3 7054 P07101-3 TH human S40 448545 RFIGRRQsLIEDARK TOH_N X 2791 -RPS6KA5 MSK1 O75582 human MSK1 9252 O75582 RPS6KA5 human S758 455798 tsTETRssssESSHS X X -RPS6KA5 MSK1 O75582 human H2A.1 319172 C0HKE1 H2ac4 mouse S1 451190 _______sGRGkQGG Histone X -EGFR EGFR P00533 human G-alpha i1 2770 P63096 GNAI1 human Y320 22641096 RKDTkEIyTHFTCAT G-alpha X X -EGFR EGFR P00533 human GSTP1 2950 P09211 GSTP1 human Y8 459294 MPPyTVVyFPVRGRC GST_N X X -EGFR EGFR P00533 human SHC1 iso3 6464 P29353-3 SHC1 human Y194 448509 EEPPDHQyyNDFPGK X -EGFR EGFR P00533 human GSTP1 2950 P09211 GSTP1 human Y4 462289 ____MPPyTVVyFPV GST_N X X -EGFR EGFR P00533 human EPS15 13858 P42567 Eps15 mouse Y850 450484 NFANFSAyPsEEDMI X -EGFR EGFR P00533 human PKCD 170538 P09215 Prkcd rat Y311 447573 TPETVGIyQGFEKKT X 2055 -EGFR EGFR P00533 human SHC1 iso3 6464 P29353-3 SHC1 human Y272 448511 ELFDDPSyVNVQNLD X -EGFR EGFR P00533 human VAV2 7410 P52735 VAV2 human Y172 452202 EDGGDDIyEDIIKVE X -EGFR EGFR P00533 human GRK2 282682 P21146 GRK2 cow Y92 456873 FyEEIKKyEKLETEE RGS X X -EGFR EGFR P00533 human CTNNB1 1499 P35222 CTNNB1 human Y142 449044 AVVNLINyQDDAELA X X -EGFR EGFR P00533 human SHC1 iso2 6464 P29353-2 SHC1 human Y239 448509 EEPPDHQyyNDFPGK X X -EGFR EGFR P00533 human PIP5K1C 18717 O70161 Pip5k1c mouse Y634 486321 DAPSTDIyFPTDERS X -EGFR EGFR P00533 human GAB1 2549 Q13480 GAB1 human Y406 447946 DAssQDCyDIPRAFP X -EGFR EGFR P00533 human PELI1 57162 Q96FA3 PELI1 human T264 1881000300 EGLSHTPtVkHLEAL X -EGFR EGFR P00533 human Calmodulin 24242 P0DP29 Calm3 rat Y100 448707 FDkDGNGyIsAAELR EF-hand_7 X -EGFR EGFR P00533 human beclin 1 8678 Q14457 BECN1 human Y233 477225 EAQyQREysEFkRQQ APG6_N X X -EGFR EGFR P00533 human RAIG1 9052 Q8NFJ5 GPRC5A human Y350 450339 WPsPykDyEVkKEGs X -EGFR EGFR P00533 human PLCG1 281987 P08487 PLCG1 cow Y472 447666 KLAEGSAyEEVPTSV X -EGFR EGFR P00533 human SQSTM1 8878 Q13501 SQSTM1 human Y433 11112748 AALDtIQyskHPPPL UBA_5 X -EGFR EGFR P00533 human PKIA 100343293 P61926 LOC100343293 rabbit Y8 451401 MTDVETTyADFIASG PKI X -EGFR EGFR P00533 human SCD 6319 O00767 SCD human Y14 457823 QDDISSSyTTTTTIT X X -EGFR EGFR P00533 human ANXA1 301 P04083 ANXA1 human Y21 447974 IENEEQEyVQtVkss X -EGFR EGFR P00533 human SCD 6319 O00767 SCD human Y55 3411245 PDIkDDIyDPTykDk X X -EGFR EGFR P00533 human Calmodulin 24242 P0DP29 Calm3 rat Y139 448708 DGDGQVNyEEFVQMM EF-hand_7 X -EGFR EGFR P00533 human HIP1 3092 O00291 HIP1 human Y152 28704600 LLRTKMEyHTkNPRF ANTH X -EGFR EGFR P00533 human PLCG1 25738 P10686 Plcg1 rat Y1253 448576 EGsFEARyQQPFEDF X -EGFR EGFR P00533 human beclin 1 8678 Q14457 BECN1 human Y229 28850302 LDQEEAQyQREysEF APG6_N X X -EGFR EGFR P00533 human PTP1B 5770 P18031 PTPN1 human Y66 447812 LHQEDNDyINAsLIk Y_phosphatase X X -EGFR EGFR P00533 human EGFR 1956 P00533 EGFR human Y1092 448057 tFLPVPEyINQsVPk X X 2236; 2234; 3777; 14565; 8543; 48576 -EGFR EGFR P00533 human GAB1 2549 Q13480 GAB1 human Y659 447949 VADERVDyVVVDQQK X 12745 -EGFR EGFR P00533 human SHC1 iso2 6464 P29353-2 SHC1 human Y240 448510 EPPDHQyyNDFPGKE X X -EGFR EGFR P00533 human GAB1 2549 Q13480 GAB1 human Y373 447945 AsDtDssyCIPTAGM X -EGFR EGFR P00533 human SHC3 iso2 53358 Q92529-2 SHC3 human Y218 451254 GDGSDHPyyNSIPSK X -EGFR EGFR P00533 human HIR 3761 P48050 KCNJ4 human Y234 19003800 YMTQEGEyLPLDQRD IRK_C X -EGFR EGFR P00533 human GAB1 2549 Q13480 GAB1 human Y589 449792 SHDSEENyVPMNPNL X -EGFR EGFR P00533 human SHC3 iso2 53358 Q92529-2 SHC3 human Y256 451255 FAGKEQTyyQGRHLG X -EGFR EGFR P00533 human PPP2CA 5515 P67775 PPP2CA human Y307 448571 VTRRtPDyFl_____ X -EGFR EGFR P00533 human PKM 5315 P14618 PKM human Y148 454768 kItLDNAyMEkCDEN PK X X -EGFR EGFR P00533 human GRF-1 232906 Q91YM2 Arhgap35 mouse Y1105 448941 RNEEENIysVPHDST RhoGAP_pG1_pG2 X -EGFR EGFR P00533 human USP8 9101 P40818 USP8 human Y810 23071951 DYFNRNCyQDDINRS UCH X -EGFR EGFR P00533 human DDEFL1 55616 Q8TDY4 ASAP3 human Y34 28704100 FAAKMPRyRGAALAR BAR_3 X X -EGFR EGFR P00533 human G-alpha i1 2770 P63096 GNAI1 human Y155 5688819 LNDSAAyyLNDLDRI G-alpha X X -EGFR EGFR P00533 human PELI1 57162 Q96FA3 PELI1 human Y154 3800785 PPFTARIyAAGFDSS Pellino X -EGFR EGFR P00533 human EGFR 1956 P00533 EGFR human Y1110 448058 GsVQNPVyHNQPLNP X X 2220 -EGFR EGFR P00533 human PLCG1 281987 P08487 PLCG1 cow Y783 447667 EGRNPGFyVEANPMP X -EGFR EGFR P00533 human KCNN1 3780 Q92952 KCNN1 human Y109 17436177 KRKRLsDyALIFGMF SK_channel X -EGFR EGFR P00533 human girdin 55704 Q3V6T2 CCDC88A human Y1799 450762 QSkDsNPyAtLPRAS X -EGFR EGFR P00533 human EGFR 1956 P00533 EGFR human Y1197 448060 stAENAEyLRVAPQS X X 2244; 4407; 47737 -EGFR EGFR P00533 human AGO2 27161 Q9UKV8 AGO2 human Y393 17533102 AsFNtDPyVREFGIM ArgoL2 X -EGFR EGFR P00533 human DNAPK 5591 P78527 PRKDC human T2609 448710 LtPMFVEtQAsQGtL DNAPKcs_CC5 X -EGFR EGFR P00533 human VAV2 7410 P52735 VAV2 human Y142 452200 TENDDDVyRSLEELA X -EGFR EGFR P00533 human RAIG1 9052 Q8NFJ5 GPRC5A human Y320 455045 GDtLyAPystHFQLQ X -EGFR EGFR P00533 human CRK 54245 Q63768 Crk rat Y221 447951 GGPEPGPyAQPsVNt X 3491 -EGFR EGFR P00533 human PFKP 5214 Q01813 PFKP human Y64 1426260400 VYFIYEGyQGMVDGG PFK X X -EGFR EGFR P00533 human GLUD1 14661 P26443 Glud1 mouse Y135 3552510 sWEVIEGyRAQHSQH ELFV_dehydrog_N X X -EGFR EGFR P00533 human SHC1 iso2 6464 P29353-2 SHC1 human Y317 448511 ELFDDPSyVNVQNLD X X -EGFR EGFR P00533 human STING 340061 Q86WV6 STING1 human Y245 1869808400 RVysNSIyELLENGQ TMEM173 X X -EGFR EGFR P00533 human PLCG1 281987 P08487 PLCG1 cow Y771 448575 IGTAEPDyGALyEGR X -EGFR EGFR P00533 human CCDC50 152137 Q8IVM0 CCDC50 human Y304 6377636 SSHkGFHyKH_____ X -EGFR EGFR P00533 human EGFR 1956 P00533 EGFR human Y1016 448055 DVVDADEyLIPQQGF X X 2235 -EGFR EGFR P00533 human ER-alpha 2099 P03372 ESR1 human S118 448101 LHPPPQLsPFLQPHG Oest_recep X 2511 -EGFR EGFR P00533 human PLCG1 5335 P19174 PLCG1 human Y771 448575 IGtAEPdyGALyEGR X -EGFR EGFR P00533 human FAK 5747 Q05397 PTK2 human Y5 7445815 ___MAAAyLDPNLNH X X -EGFR EGFR P00533 human PCNA 5111 P12004 PCNA human Y211 471414 QLTFALryLNFFtkA PCNA_C X X -EGFR EGFR P00533 human SPRED1 161742 Q7Z699 SPRED1 human S105 36131862 KFGLTFQsPADARAF WH1 X -EGFR EGFR P00533 human PLD2 5338 O14939 PLD2 human Y296 10036102 LILkCSSyRQARWWA X -EGFR EGFR P00533 human USP8 9101 P40818 USP8 human Y717 484371 PsKLKRsyssPDItQ X -EGFR EGFR P00533 human SCD 6319 O00767 SCD human Y41 3411240 kLETMPLyLEDDIRP X X -EGFR EGFR P00533 human EGFR 1956 P00533 EGFR human Y869 448061 LGAEEkEyHAEGGkV PK_Tyr_Ser-Thr X 2231; 6963 -EGFR EGFR P00533 human ACTN4 60595 P57780 Actn4 mouse Y4 11498501 ____MVDyHAANQAY X -EGFR EGFR P00533 human VAV2 7410 P52735 VAV2 human Y159 452201 HDLGEDIyDCVPCED X -EGFR EGFR P00533 human beclin 1 8678 Q14457 BECN1 human Y352 28850301 KSKELPLyCSGGLRF APG6 X X -EGFR EGFR P00533 human PLCG1 25738 P10686 Plcg1 rat Y783 447667 EGRNPGFyVEANPMP X 2821; 14461; 14008; 25678; 88717 -EGFR EGFR P00533 human PKCD 170538 P09215 Prkcd rat Y332 450077 IPDNNGTyGKIWEGS X -EGFR EGFR P00533 human EPB41 iso4 2035 P11171-4 EPB41 human Y418 451704 RLDGENIyIRHSNLM X -EGFR EGFR P00533 human GAB1 2549 Q13480 GAB1 human Y447 449791 SEELDENyVPMNPNs X -EGFR EGFR P00533 human ACTN4 60595 P57780 Actn4 mouse Y32 11498502 GGGSMGDyMAQEDDW X -EGFR EGFR P00533 human GAB1 2549 Q13480 GAB1 human Y472 447947 EPIQEANyVPMtPGT X -EGFR EGFR P00533 human SHC1 iso3 6464 P29353-3 SHC1 human Y195 448510 EPPDHQyyNDFPGKE X -EGFR EGFR P00533 human FAM129B 64855 Q96TA1 NIBAN2 human Y593 25299904 PIDWGEEysNSGGGG X X -EGFR EGFR P00533 human HDAC6 10013 Q9UBN7 HDAC6 human Y570 12127406 SSNFDSIyICPSTFA Hist_deacetyl X -EGFR EGFR P00533 human LRRK1 79705 Q38SD2 LRRK1 human Y971 23303206 TQQTEEQyFQFLAKF COR X X -EGFR EGFR P00533 human ATM 472 Q13315 ATM human Y370 38535268 SLEIsQSyTttQRES X X -EGFR EGFR P00533 human PDP1 54704 Q9P0J1 PDP1 human Y381 15422118 DQLNDNEyTkFIPPN PP2C X -EGFR EGFR P00533 human PLCG1 5335 P19174 PLCG1 human Y783 447667 EGRNPGFyVEANPMP X 2821; 14461; 14008; 25678; 88717 -EGFR EGFR P00533 human HDAC1 3065 Q13547 HDAC1 human Y72 55375010 TkYHSDDyIkFLRSI Hist_deacetyl X -EGFR EGFR P00533 human TLR3 7098 O15455 TLR3 human Y858 25680401 FLEEIPDyKLNHALC TIR X X -EGFR EGFR P00533 human ABCA1 19 O95477 ABCA1 human S2054 455498 GGNkRKLsTAMALIG ABC_tran X -EGFR EGFR P00533 human RGS16 6004 O15492 RGS16 human Y168 448652 TLMEKDSyPRFLkSP RGS X -EGFR EGFR P00533 human G-alpha i1 2770 P63096 GNAI1 human Y154 1871177702 QLNDSAAyyLNDLDR G-alpha X X -EGFR EGFR P00533 human FAK 5747 Q05397 PTK2 human Y194 18122800 ALEKKSNyEVLEkDV FERM_M X X -EGFR EGFR P00533 human CTNNB1 1499 P35222 CTNNB1 human Y654 447585 RNEGVAtyAAAVLFR X -EGFR EGFR P00533 human Daple 440193 Q9P219 CCDC88C human Y2025 899136400 PQTVWyEyGCV____ X -EGFR EGFR P00533 human Ezrin 7430 P15311 EZR human Y354 448105 LMLRLQDyEEktKKA ERM_helical X 3144; 5484 -EGFR EGFR P00533 human TRIP13 9319 Q15645 TRIP13 human Y206 35479941 RLSSRYRyGQLIEIN AAA X -EGFR EGFR P00533 human LYN 4067 P07948 LYN human Y32 454717 RNTERtIyVRDPTSN X X -EGFR EGFR P00533 human GAB1 2549 Q13480 GAB1 human Y285 449801 TEADGELyVFNTPSG X -EGFR EGFR P00533 human ZNRF1 170737 Q91V17 Znrf1 mouse Y103 479016 TyAHGNGyQETGGGH X -EGFR EGFR P00533 human GSTP1 2950 P09211 GSTP1 human Y199 463460 AFLAsPEyVNLPING X X -EGFR EGFR P00533 human CCDC50 152137 Q8IVM0 CCDC50 human Y279 462101 tDGEDADytHFtNQQ X -EGFR EGFR P00533 human SOX2 6657 P48431 SOX2 human Y277 27722639 LRDMISMyLPGAEVP X -EGFR EGFR P00533 human IKKE 9641 Q14164 IKBKE human Y179 23115344 sVYGTEEyLHPDMYE Pkinase X -EGFR EGFR P00533 human Kv4.3 3752 Q9UK17 KCND3 human Y136 23045803 GDCCYEEyKDRKREN X -EGFR EGFR P00533 human RAIG1 9052 Q8NFJ5 GPRC5A human Y317 451750 EEtGDtLyAPystHF X -EGFR EGFR P00533 human girdin 55704 Q3V6T2 CCDC88A human Y1765 450761 PRktEDtyFISSAGk X -EGFR EGFR P00533 human GRK2 282682 P21146 GRK2 cow Y86 447727 AKPLVEFyEEIKKyE RGS X X -EGFR EGFR P00533 human CCDC50 152137 Q8IVM0 CCDC50 human Y217 6377637 MAEEkKAykkAkERE X -EGFR EGFR P00533 human RAIG1 9052 Q8NFJ5 GPRC5A human Y347 450338 AHAWPsPykDyEVkK X -EGFR EGFR P00533 human SHC3 iso2 53358 Q92529-2 SHC3 human Y301 451259 PTGEAPTyVNTQQIP X -EGFR EGFR P00533 human Ezrin 7430 P15311 EZR human Y146 448758 kEVHksGyLSsERLI FERM_M X -EGFR EGFR P00533 human MRLC3 10627 P19105 MYL12A human Y155 7382105 DkkGNFNyIEFTRIL EF-hand_11 X -EGFR EGFR P00533 human SHC3 iso2 53358 Q92529-2 SHC3 human Y257 451256 AGKEQTyyQGRHLGD X -EGFR EGFR P00533 human PPAR-delta 5467 Q03181 PPARD human Y108 1868968410 TIRMKLEyEKCERSC zf-C4 X X -EGFR EGFR P00533 human GRK2 282682 P21146 GRK2 cow Y13 456872 AVLADVSyLMAMEKS X X -EGFR EGFR P00533 human SHC3 iso2 53358 Q92529-2 SHC3 human Y283 451257 RQGSSDIySTPEGKL X -EGFR EGFR P00533 human RASA1 25676 P50904 Rasa1 rat Y451 449959 TVDGKEIyNTIRRKT X X -EGFR EGFR P00533 human PPAR-gamma iso2 5468 P37231-2 PPARG human Y74 9256871 YDLKLQEyQSAIkVE PPARgamma_N X X -EGFR EGFR P00533 human SHC3 iso2 53358 Q92529-2 SHC3 human Y219 451258 DGSDHPyyNSIPSKM X -EGFR EGFR P00533 human EGFR 1956 P00533 EGFR human Y1172 448059 IsLDNPDyQQDFFPk X X 4404 -EGFR EGFR P00533 human GAB1 2549 Q13480 GAB1 human Y627 447948 KGDKQVEyLDLDLDs X 3231; 3233 -EGFR EGFR P00533 human TRIP13 9319 Q15645 TRIP13 human Y56 450833 HNIVFGDyTWTEFDE X X -EGFR EGFR P00533 human PLCG1 281987 P08487 PLCG1 cow Y1254 448576 EGsFEARyQQPFEDF X -EGFR EGFR P00533 human IKKE 9641 Q14164 IKBKE human Y153 56589701 GEEGQSIykLTDFGA Pkinase X -MYLK2 skMLCK P07313 rabbit skMLCK P07313 MYLK2 rabbit S235 2869608 AKVQGDTsRGIEFQA X -MYLK2 skMLCK P07313 rabbit skMLCK P07313 MYLK2 rabbit S161 2864200 PAFLHSPsCPAIIAS X -PAK2 PAK2 Q13177 human smMLCK 100009143 P29294 MYLK rabbit S991 452099 VRAIGRLsSMAMISG X -PAK2 PAK2 Q13177 human Myc 4609 P01106 MYC human S388 450961 RRNELkRsFFALRDQ HLH X X -PAK2 PAK2 Q13177 human ARHGAP15 55843 Q53QZ3 ARHGAP15 human S292 28712601 kVCERENsTVPWFVk X -PAK2 PAK2 Q13177 human H4 8359 P62805 H4C1 human S47 449870 RGGVKrIsGLIyEEt CENP-T_C X X -PAK2 PAK2 Q13177 human Jun 3725 P05412 JUN human T2 17737603 ______MtAKMETtF X X -PAK2 PAK2 Q13177 human Caldesmon 800 Q05682 CALD1 human S744 456707 GLKVGVSsRINEWLT Caldesmon X -PAK2 PAK2 Q13177 human Jun 3725 P05412 JUN human T286 17737605 RLEEKVKtLKAQNSE bZIP_1 X X -PAK2 PAK2 Q13177 human Myc 4609 P01106 MYC human T373 450960 EENVkRRtHNVLERQ HLH X -PAK2 PAK2 Q13177 human MICAL1 64780 Q8TDZ2 MICAL1 human S817 5434440 sPERQRLssLNLtPD X -PAK2 PAK2 Q13177 human SORT1 6272 Q99523 SORT1 human S793 3823097 RFLVHRYsVLQQHAE X -PAK2 PAK2 Q13177 human RhoGDI alpha 360678 Q5XI73 Arhgdia rat S101 452195 LESFKkQsFVLkEGV Rho_GDI X X -PAK2 PAK2 Q13177 human Mnk1 17346 O08605 Mknk1 mouse T34 454028 RRKKKRKtRATDsLP X -PAK2 PAK2 Q13177 human CASP7 840 P55210 CASP7 human S239 20473607 WRsPGRGsWFVQALC Peptidase_C14 X X -PAK2 PAK2 Q13177 human Abl 25 P00519 ABL1 human S619 1779805 PtPPKRsssFREMDG X X -PAK2 PAK2 Q13177 human PAK2 5062 Q13177 PAK2 human S192 448296 PRPDHTksIytRsVI X 2605 -PAK2 PAK2 Q13177 human smMLCK 100009143 P29294 MYLK rabbit S439 452098 MKSRRPKsSLPPVLG X -PAK2 PAK2 Q13177 human PAK2 5062 Q13177 PAK2 human S141 448295 tVkQKyLsFtPPEkd X 2606 -PAK2 PAK2 Q13177 human SMAD2 4087 Q15796 SMAD2 human S467 447495 sVRCssMs_______ X 3108; 8828; 11979; 26945; 55041; 68550; 18338; 56532; 67804 -PAK2 PAK2 Q13177 human Merlin 4771 P35240 NF2 human S518 448282 DTDMKRLsMEIEKEK ERM_C X X 9163; 13281 -PAK2 PAK2 Q13177 human SMAD2 4087 Q15796 SMAD2 human S417 447569 RMCTIRMsFVkGWGA MH2 X X -PAK2 PAK2 Q13177 human eIF4G 1981 Q04637 EIF4G1 human S895 458380 RDIARRRsLGNIkFI MIF4G X -PAK2 PAK2 Q13177 human ARHGAP15 55843 Q53QZ3 ARHGAP15 human S4 28712600 ____MQKsTNsDTSV X -PAK2 PAK2 Q13177 human RORC 19885 P51450 Rorc mouse S337 25308318 VEFAKRLsGFMELCQ Hormone_recep X X -PAK2 PAK2 Q13177 human SYN1 281510 P17599 SYN1 cow S551 451574 PATRPPAsPsPQRQA X -PAK2 PAK2 Q13177 human ARHGAP15 55843 Q53QZ3 ARHGAP15 human S43 14159324 DRLsQsksMILTDVG X -PAK2 PAK2 Q13177 human PAK2 5062 Q13177 PAK2 human T402 448300 PEQSkRstMVGtPYW Pkinase X 2601 -PAK2 PAK2 Q13177 human RhoGDI alpha 360678 Q5XI73 Arhgdia rat S34 467490 YkPPAQKsIQEIQEL Rho_GDI X X -PAK2 PAK2 Q13177 human PAK2 224105 Q8CIN4 Pak2 mouse S141 448295 TVkQKyLsFtPPEKD X 2606 -PAK2 PAK2 Q13177 human Jun 3725 P05412 JUN human T8 17737604 MtAKMETtFYDDALN Jun X X -PAK2 PAK2 Q13177 human SMAD2 4087 Q15796 SMAD2 human S465 447494 sPsVRCssMs_____ X 3108; 8828; 11979; 26945; 55041; 68550; 18338; 56532; 67804 -PAK2 PAK2 Q13177 human Myc 4609 P01106 MYC human T415 450962 VVILKkAtAYILsVQ HLH X -PAK2 PAK2 Q13177 human PXN 5829 P49023 PXN human S272 465466 ELDELMAsLsDFkIQ X -PAK2 PAK2 Q13177 human CASP7 840 P55210 CASP7 human S30 12069580 DAKPDRssFVPsLFs X X -PAK2 PAK2 Q13177 human Caldesmon 800 Q05682 CALD1 human S714 456706 EGVRNIksMWEkGNV Caldesmon X -PAK2 PAK2 Q13177 human ARHGAP15 55843 Q53QZ3 ARHGAP15 human S41 23083229 HHDRLsQsksMILTD X -PAK2 PAK2 Q13177 human ERK3 5597 Q16659 MAPK6 human S189 448267 ySHKGHLsEGLVTkW Pkinase X -PAK2 PAK2 Q13177 human PXN 5829 P49023 PXN human S274 465490 DELMAsLsDFkIQGL X -PAK2 PAK2 Q13177 human PAK2 5062 Q13177 PAK2 human S197 448297 TksIytRsVIDPVPA X 2605 -PAK2 PAK2 Q13177 human CASP7 840 P55210 CASP7 human T173 20473606 FRGDRCktLLEkPKL Peptidase_C14 X X -PAK2 PAK2 Q13177 human CTNNB1 1499 P35222 CTNNB1 human S552 472273 QDtQRRtsMGGtQQQ X 9566; 5651 -PAK2 PAK2 Q13177 human Mnk1 17346 O08605 Mknk1 mouse S39 454027 RKtRATDsLPGKFED X -PAK2 PAK2 Q13177 human SYN1 281510 P17599 SYN1 cow S605 450236 AGPTRQAsQAGPMPR X -PAK2 PAK2 Q13177 human SMAD2 4087 Q15796 SMAD2 human S464 447567 GsPsVRCssMs____ X -PAK2 PAK2 Q13177 human Jun 3725 P05412 JUN human T89 17737602 QSSNGHItTtPtPtQ Jun X X -PAK2 PAK2 Q13177 human SYN1 281510 P17599 SYN1 cow S9 448378 NYLRRRLsDSNFMAN Synapsin_N X -PAK2 PAK2 Q13177 human PREX2 80243 Q70Z35 PREX2 human S1107 35483225 DTISNRDsYSDCNSN X -PAK2 PAK2 Q13177 human RAF1 5894 P04049 RAF1 human S338 447742 RPRGQRDssyyWEIE X X 9427 -PAK2 PAK2 Q13177 human MICAL1 64780 Q8TDZ2 MICAL1 human S960 6226101 ELALRRQssSPEQQK bMERB_dom X -PAK2 PAK2 Q13177 human HACE1 57531 Q8IYU2 HACE1 human S385 10940679 LMKNKRDsTEITsIL X -PAK2 PAK2 Q13177 human SLC25A5 292 P05141 SLC25A5 human T107 1876923700 LGGVDkRtQFWLyFA X -PAK2 PAK2 Q13177 human Jun 3725 P05412 JUN human T93 450449 GHItTtPtPtQFLCP Jun X X 2993 -PAK2 PAK2 Q13177 human Abl 25 P00519 ABL1 human S618 1779804 APtPPKRsssFREMD X X -MAP4K5 KHS1 Q9Y4K4 human GSK3B 56637 Q9WV60 Gsk3b mouse S9 449111 SGRPRttsFAEsCKP X 9336; 9331; 9327; 9323; 9322; 9325; 5558; 8566; 79774; 8466; 25462; 14026; 14332; 14310; 14630 -MAP4K5 KHS1 Q9Y4K4 human GSK3B 2932 P49841 GSK3B human S9 449111 SGRPRttsFAEsCkP X X 9336; 9331; 9327; 9323; 9322; 9325; 5558; 8566; 79774; 8466; 25462; 14026; 14332; 14310; 14630 -Nlk NLK O54949 mouse Huntingtin 15194 P42859 Htt mouse S120 1869087500 LCSNDAEsDVRMVAD X X -NTRK3 TrkC Q16288 human NLGN1 192167 Q99K10 Nlgn1 mouse Y782 1008111 RTACPPDyTLAMRRS X -Mastl MASTL Q8C0P0 mouse ENSA 56205 P60840 Ensa mouse S67 455934 KGQkyFDsGDyNMAK Endosulfine X 5240 -Mapk9 JNK2 Q9WTU6 mouse DLK 26404 Q60700 Map3k12 mouse S533 27447446 RNVPQKLsPHSKRPD X X -Mapk9 JNK2 Q9WTU6 mouse NFAT3 4776 Q14934 NFATC4 human S217 953803 GLGsPLPsPRAsPRP X -Mapk9 JNK2 Q9WTU6 mouse BMAL1 406 O00327 BMAL1 human S592 25352000 DNDQGSSsPSNDEAA X -Mapk9 JNK2 Q9WTU6 mouse RXRA 20181 P28700 Rxra mouse S265 450891 NMGLNPSsPNDPVTN Hormone_recep X -Mapk9 JNK2 Q9WTU6 mouse BMAL1 406 O00327 BMAL1 human S520 25352001 SPSSCGSsPLNITSt X -Mapk9 JNK2 Q9WTU6 mouse LISCH iso2 54135 Q99KG5-2 Lsr mouse S288 4771509 PGDFDRTsSVGGHSS X -Mapk9 JNK2 Q9WTU6 mouse RXRA 20181 P28700 Rxra mouse S61 453094 SPISTLSsPINGMGP Nuc_recep-AF1 X -Mapk9 JNK2 Q9WTU6 mouse DLK 26404 Q60700 Map3k12 mouse T43 4727854 CtPEKDLtPTQCVLR X X -Mapk9 JNK2 Q9WTU6 mouse BIM 12125 O54918 Bcl2l11 mouse S65 449330 GPLAPPAsPGPFATR X 4581; 4585 -Mapk9 JNK2 Q9WTU6 mouse RXRA 20181 P28700 Rxra mouse S75 453095 PPFSVISsPMGPHSM Nuc_recep-AF1 X -Mapk9 JNK2 Q9WTU6 mouse RXRA 20181 P28700 Rxra mouse T87 453096 HSMSVPTtPTLGFGT Nuc_recep-AF1 X -Mapk9 JNK2 Q9WTU6 mouse NFAT3 4776 Q14934 NFATC4 human S213 953804 ASRFGLGsPLPsPRA X -Mapk9 JNK2 Q9WTU6 mouse H3 iso3 15081 P84244 H3f3b mouse S28 455677 ATkAArksAPSTGGV Histone X 9713 -Mapk9 JNK2 Q9WTU6 mouse Jun 16476 P05627 Jun mouse S63 447686 kNsDLLtsPDVGLLK Jun X 5464; 9261; 2361; 97721; 91952 -Mapk9 JNK2 Q9WTU6 mouse p70S6K 6198 P23443 RPS6KB1 human S434 448356 sFEPKIRsPRRFIGs X -Mapk9 JNK2 Q9WTU6 mouse H2AX 15270 P27661 H2ax mouse S139 448841 GkKAsQAsQEy____ X X 2577; 9719; 9720; 9718; 4309; 5763; 5438; 93629; 80312; 20304; 85410; 97148; 60566; 59141 -Mapk9 JNK2 Q9WTU6 mouse Ets-2 23872 P15037 Ets2 mouse T72 447688 SCELPLLtPCSKAVM X -Mapk9 JNK2 Q9WTU6 mouse BMAL1 406 O00327 BMAL1 human T527 448633 sPLNITStPPPDASS X -Jak2 JAK2 Q62689 rat STAT5A 24918 Q62771 Stat5a rat Y694 447767 LAKAVDGyVKPQIKQ X 9365; 9356; 9359; 9351; 4322; 9314; 3939; 40284; 5387; 14603; 66740; 51879; 72712 -Jak2 JAK2 Q62689 rat GH receptor 25235 P16310 Ghr rat Y338 455508 DNyKPDFyNDDSWVE GHBP X -Jak2 JAK2 Q62689 rat STAT5B 25126 P52632 Stat5b rat Y699 448198 TAKAADGyVKPQIKQ X 9365; 9356; 9359; 9351; 4322; 9314; 3939; 40284; 5387; 14603; 66740; 51879; 72712 -Jak2 JAK2 Q62689 rat GH receptor 25235 P16310 Ghr rat Y333 455507 ILGIHDNyKPDFyND GHBP X -Eef2k EEF2K P70531 rat EEF2 29565 P05197 Eef2 rat T57 448040 RAGEtRFtDtRKDEQ GTP_EFTU X X 2331 -STK17A DRAK1 Q9UEE5 human p53 7157 P04637 TP53 human S20 447529 PLsQEtFsDLWkLLP P53_TAD X 9287 -Map3k1 MEKK1 P53349 mouse MEK1 170851 Q01986 Map2k1 rat S218 448514 VsGQLIDsMANsFVG Pkinase X 9121; 3958; 9154; 86128 -Map3k1 MEKK1 P53349 mouse MEKK1 26401 P53349 Map3k1 mouse T1393 448079 FQGQLLGtIAFMAPE Pkinase X -Map3k1 MEKK1 P53349 mouse MEKK1 26401 P53349 Map3k1 mouse T1381 448078 ARLASKGtGAGEFQG Pkinase X X -Map3k1 MEKK1 P53349 mouse STAT3 20848 P42227 Stat3 mouse S727 448191 NtIDLPMsPRTLDSL X X 9134; 9136; 34911; 94994; 49081; 58978; 87544; 71958; 50804 -Map3k1 MEKK1 P53349 mouse MEK1 170851 Q01986 Map2k1 rat S222 448513 LIDsMANsFVGTRSY Pkinase X 2338; 9121; 3958; 9154; 16211; 86128; 16780; 75262 -MAPK15 ERK7 Q8TD08 human ERK7 225689 Q8TD08 MAPK15 human T381 459223 DPQLPsRtPVQGPRP X -MAPK15 ERK7 Q8TD08 human ERK7 225689 Q8TD08 MAPK15 human Y177 459217 EDQAVtEyVATRWYR Pkinase X X -MAPK15 ERK7 Q8TD08 human ERK7 225689 Q8TD08 MAPK15 human S192 459218 APEVLLSsHRYTLGV Pkinase X -MAPK15 ERK7 Q8TD08 human ERK7 225689 Q8TD08 MAPK15 human S331 459219 AHEGVQLsVPEYRSR X -MAPK15 ERK7 Q8TD08 human ERK7 225689 Q8TD08 MAPK15 human S362 459221 EKGPEGVsPSQAHLH X -MAPK15 ERK7 Q8TD08 human IkB-alpha 4792 P25963 NFKBIA human S32 448203 LLDDRHDsGLDsMkD X X 5210; 2859; 9246; 5209 -MAPK15 ERK7 Q8TD08 human ERK7 225689 Q8TD08 MAPK15 human S379 459222 RADPQLPsRtPVQGP X -MAPK15 ERK7 Q8TD08 human IkB-alpha 4792 P25963 NFKBIA human S36 448204 RHDsGLDsMkDEEyE X X 5210; 9246 -MAPK15 ERK7 Q8TD08 human Jun 3725 P05412 JUN human S73 447943 VGLLkLAsPELERLI Jun X X 9164; 3270; 8752; 12714; 77955 -MAPK15 ERK7 Q8TD08 human Jun 3725 P05412 JUN human S63 447686 kNsDLLtsPDVGLLk Jun X X 5464; 9261; 2361; 97721; 91952 -MAPK15 ERK7 Q8TD08 human ERK7 225689 Q8TD08 MAPK15 human T175 459216 GPEDQAVtEyVATRW Pkinase X X -MAPK15 ERK7 Q8TD08 human ERK7 225689 Q8TD08 MAPK15 human T352 459220 ECGGSSGtSREKGPE X -Cdkl5 CDKL5 Q3UTQ8 mouse ARHGEF2 16800 Q60875 Arhgef2 mouse S122 4770069 TTRERPtsAIyPsDs X -Cdkl5 CDKL5 Q3UTQ8 mouse RP1 212307 Q8R001 Mapre2 mouse S222 476320 STPsRPssAKRASSS X X -Cdkl5 CDKL5 Q3UTQ8 mouse BPY2-IP1 270058 Q8C052 Map1s mouse S812 476391 GDRNRPLsARSEPAD X X -Cdkl5 CDKL5 Q3UTQ8 mouse BPY2-IP1 270058 Q8C052 Map1s mouse S786 27444827 KAPARPssAsAtPRA X X -Tyro3 Tyro3 P55144 mouse Tyro3 22174 P55144 Tyro3 mouse Y756 150180313 EEVYDLMyQCWSADP PK_Tyr_Ser-Thr X -Tyro3 Tyro3 P55144 mouse Tyro3 22174 P55144 Tyro3 mouse Y723 150180314 MTRGQTPyAGIENAE PK_Tyr_Ser-Thr X -AKT1 Akt1 P31749 human DIABLO 56616 Q9NR28 DIABLO human S67 29431803 AQkSEPHsLSSEALM Smac_DIABLO X X -AKT1 Akt1 P31749 human BEX1 501625 Q3MKQ2 Bex1 rat S105 14788300 KLRERQLsHSLRAVS BEX X X -AKT1 Akt1 P31749 human BIM 10018 O43521 BCL2L11 human S87 458219 FIFMRRSsLLSRSss X -AKT1 Akt1 P31749 human PKM 5315 P14618 PKM human S222 27110046 AVDLPAVsEkDIQDL PK X X -AKT1 Akt1 P31749 human TFEB 7942 P19484 TFEB human S467 4785142 KASsRRssFsMEEGD DUF3371 X X -AKT1 Akt1 P31749 human CTNND2 18163 O35927 Ctnnd2 mouse T454 480958 tGTFRtstAPssPGV X -AKT1 Akt1 P31749 human PLCG1 5335 P19174 PLCG1 human S1248 448665 HGrAREGsFEsRyQQ X 4510; 13349; 8713 -AKT1 Akt1 P31749 human CACNB2 116600 Q8VGC3 Cacnb2 rat S625 469619 KQRSRHKsKDRYCDK X -AKT1 Akt1 P31749 human MLK3 4296 Q16584 MAP3K11 human S674 448790 PGRERGEsPTtPPTP X X -AKT1 Akt1 P31749 human AS160 9882 O60343 TBC1D4 human S318 455925 EFRsRCssVtGVQRR PID X X 8619 -AKT1 Akt1 P31749 human RALGAPA2 57186 Q2PPJ7 RALGAPA2 human T715 460565 PMRFRsAttSGAPGV X -AKT1 Akt1 P31749 human SIK 150094 P57059 SIK1 human S435 7445611 VFRPRPVsPsSLLDT X X -AKT1 Akt1 P31749 human PHB 5245 P35232 PHB1 human T258 11139253 LSRSRNItyLPAGQs X -AKT1 Akt1 P31749 human PCK1 5105 P35558 PCK1 human S90 1868515110 RDVARIEsktVIVTQ PEPCK_N X X -AKT1 Akt1 P31749 human Nur77 79240 P22829 Nr4a1 rat S350 447942 GRRGRLPsKPKQPPD X X 5095 -AKT1 Akt1 P31749 human MST1 6789 Q13043 STK4 human T183 447925 DtMAkRNtVIGTPFW Pkinase X 3681; 49332 -AKT1 Akt1 P31749 human AMPKA1 5562 Q13131 PRKAA1 human S494 4717473 GtAtPQRsGsVsNyR AdenylateSensor X -AKT1 Akt1 P31749 human Merlin 4771 P35240 NF2 human S315 487469 MRRRKADsLEVQQMk FERM_C X -AKT1 Akt1 P31749 human acinus 305884 E9PST5 Acin1 rat S1180 456759 GPRSRSRsRDRRRKE RSB_motif X -AKT1 Akt1 P31749 human TOPBP1 11073 Q92547 TOPBP1 human S1159 472408 EERARLAsNLQWPSC X X -AKT1 Akt1 P31749 human TWIST1 7291 Q15672 TWIST1 human T121 38546302 NVRERQRtQsLNEAF HLH X X -AKT1 Akt1 P31749 human BACH2 12014 P97303 Bach2 mouse S520 470117 EtRTRtsssCssYsY X -AKT1 Akt1 P31749 human NFkB-p65 309165 Q7TQN4 Rela rat S535 447800 sGDEDFSsIADMDFS X 4887; 3036; 3031; 4886; 3033; 4025; 5733; 13346; 76778; 31553; 80477; 73992; 87672; 83962 -AKT1 Akt1 P31749 human NHE1 6548 P19634 SLC9A1 human S703 448347 MsRARIGsDPLAyEP X -AKT1 Akt1 P31749 human APS 114203 Q9Z200 Sh2b2 rat S588 456846 SARSRSNsTEHLLEA X X -AKT1 Akt1 P31749 human EGFR 1956 P00533 EGFR human S229 18944906 rCrGKSPsDCCHNQC Furin-like X X -AKT1 Akt1 P31749 human TBC1D1 57915 Q60949 Tbc1d1 mouse S700 2228807 KKLHssssVPNFLKF X 6929 -AKT1 Akt1 P31749 human CABLES1 91768 Q8TDN4 CABLES1 human T415 3207279 AFGARRNtIDstSsF X X -AKT1 Akt1 P31749 human p21Cip1 12575 P39689 Cdkn1a mouse T140 447837 QGRKRRQtsLTDFYH X -AKT1 Akt1 P31749 human p21Cip1 1026 P38936 CDKN1A human S146 447836 GRkRRQtsMTDFyHs X X -AKT1 Akt1 P31749 human Btk 695 Q06187 BTK human S51 28710300 FERGRRGsKKGsIDV PH X -AKT1 Akt1 P31749 human MITF 4286 O75030 MITF human S516 450265 KtssRRssMSMEETE DUF3371 X X -AKT1 Akt1 P31749 human IRAK1 3654 P51617 IRAK1 human T100 447720 LRARDIItAWHPPAP Death X -AKT1 Akt1 P31749 human PPP1CA 5499 P62136 PPP1CA human T320 448686 NPGGRPItPPRNsAK X 2581 -AKT1 Akt1 P31749 human PANK4 55229 Q9NVE7 PANK4 human T406 478688 AQRARsGtFDLLEMD X X -AKT1 Akt1 P31749 human CK1D 64462 Q06486 Csnk1d rat S370 483997 MERERKVsMRLHRGA X -AKT1 Akt1 P31749 human CSK 12988 P41241 Csk mouse S284 23096469 YLRSRGRsVLGGDCL PK_Tyr_Ser-Thr X -AKT1 Akt1 P31749 human SKI 6497 P12755 SKI human T458 11279400 QPRKRKLtVDTPGAP X X -AKT1 Akt1 P31749 human CARD11 84433 Q9BXL7 CARD11 human S652 457639 LERPFRPsVtsVGHV X 5189 -AKT1 Akt1 P31749 human TWIST1 7291 Q15672 TWIST1 human S42 14821304 GGRkRRSsRRsAGGG X X -AKT1 Akt1 P31749 human MST1 6789 Q13043 STK4 human T120 11496001 IIRLRNktLTEDEIA Pkinase X X -AKT1 Akt1 P31749 human FOXO4 4303 P98177 FOXO4 human S262 448517 TFRPRSssNAsSVsT X X -AKT1 Akt1 P31749 human RARA 5914 P10276 RARA human S96 465508 FVCQDKSsGYHYGVS zf-C4 X X -AKT1 Akt1 P31749 human PRPK 112858 Q96S44 TP53RK human S250 1981300 RLRGRKRsMVG____ X X -AKT1 Akt1 P31749 human K19 3880 P08727 KRT19 human S35 449970 GVAFrAPsIHGGsGG X X -AKT1 Akt1 P31749 human TBC1D1 57915 Q60949 Tbc1d1 mouse S231 2103609 RPMRKsFsQPGLRSL X -AKT1 Akt1 P31749 human 14-3-3 zeta 7534 P63104 YWHAZ human S58 449833 VVGARRssWRVVssI 14-3-3 X X 52631 -AKT1 Akt1 P31749 human CBY1 25776 Q9Y3M2 CBY1 human S20 2850009 TPPRKsAsLSNLHsL Chibby X -AKT1 Akt1 P31749 human CELF1 10658 Q92879 CELF1 human S28 3347300 GQVPrtWsEkDLREL RRM_1 X -AKT1 Akt1 P31749 human ER-beta 13983 O08537 Esr2 mouse S236 473056 VRRQRSAsEQVHCLN X -AKT1 Akt1 P31749 human PDCD4 27250 Q53EL6 PDCD4 human S67 458381 kRRLRKNssRDsGrG X X -AKT1 Akt1 P31749 human Sin1 227743 Q8BKH7 Mapkap1 mouse T86 3253548 GIRRRSNtAQRLERL SIN1 X 14716 -AKT1 Akt1 P31749 human p57Kip2 1028 P49918 CDKN1C human T310 450869 GVGsVEQtPRKRLR_ X X 2558 -AKT1 Akt1 P31749 human PHF20 51230 Q9BVI0 PHF20 human S265 15413296 RKRGRPPsIAPTAVD DUF3776 X -AKT1 Akt1 P31749 human eNOS 397557 Q7YSG7 NOS3 pig S1179 447884 TSRIRtQsFSLQERH X -AKT1 Akt1 P31749 human HSF1 3297 Q00613 HSF1 human S230 448072 PkYSRQFsLEHVHGS X X -AKT1 Akt1 P31749 human BMI1 648 P35226 BMI1 human S316 6150348 ANRPRKssVNGSSAT X X -AKT1 Akt1 P31749 human CLK2 1196 P49760 CLK2 human S34 15339201 HKRRRSRsWSSSSDR X X -AKT1 Akt1 P31749 human mTOR 2475 P42345 MTOR human S2448 447578 RsRtRtDsysAGQsV X X 2971; 2976; 5536; 54932 -AKT1 Akt1 P31749 human PYGO2 90780 Q9BRQ0 PYGO2 human S48 5965932 PEKKRRKsNtQGPAY X X -AKT1 Akt1 P31749 human FOXG1 15228 Q60987 Foxg1 mouse T271 482881 KLRRRSTtSRAKLAF X X -AKT1 Akt1 P31749 human ACLY 47 P53396 ACLY human S455 448631 PAPsRtAsFsEsRAD X 4331 -AKT1 Akt1 P31749 human PFKFB2 5208 O60825 PFKFB2 human S466 448460 PVRMRRNsFtPLssS X X -AKT1 Akt1 P31749 human FOXO1A 84482 G3V7R4 Foxo1 rat S313 449113 TFRPRTSsNAsTIsG X 2486 -AKT1 Akt1 P31749 human SHP-1 15170 P29351 Ptpn6 mouse T394 23144271 TAEYkLRtLQISPLD Y_phosphatase X -AKT1 Akt1 P31749 human NuaK1 9891 O60285 NUAK1 human S600 448726 PARQRIRsCVsAENF X X -AKT1 Akt1 P31749 human AurB 9212 Q96GD4 AURKB human T73 23085287 DILTRHFtIDDFEIG X X -AKT1 Akt1 P31749 human ADAR 103 P55265 ADAR human T1033 1868546602 RLGERLRtMSCSDKI A_deamin X X -AKT1 Akt1 P31749 human INVS 27130 Q9Y283 INVS human T866 55578723 ARRLEtstLSEDFQV X X -AKT1 Akt1 P31749 human HSF1 3297 Q00613 HSF1 human T527 1876167504 PPKAkDPtVS_____ Vert_HS_TF X -AKT1 Akt1 P31749 human DEPDC5 9681 O75140 DEPDC5 human S1530 3845300 QQRRRRNstSSTNQN DEPDC5_CTD X -AKT1 Akt1 P31749 human p27Kip1 1027 P46527 CDKN1B human T157 448645 GIRkrPAtDDSSTQN X X -AKT1 Akt1 P31749 human SFRS3 6428 P84103 SRSF3 human S128 6421243 FsRsRsRsLsRDRRR X -AKT1 Akt1 P31749 human MST2 6788 Q13188 STK3 human T384 3195191 GtMKRNAtsPQVQRP X X -AKT1 Akt1 P31749 human BRCA1 672 P38398 BRCA1 human S694 4787521 QTSKRHDsDTFPELk X X -AKT1 Akt1 P31749 human MLL4 iso3 8085 O14686-3 KMT2D human S1331 1217705 RGRARLKsTASSIET X -AKT1 Akt1 P31749 human PIKFYVE iso1 18711 Q9Z1T6-1 Pikfyve mouse S105 14881303 EELHRRSsVLENTLP X -AKT1 Akt1 P31749 human CLOCK 12753 O08785 Clock mouse S845 23094535 LPRHRtDsLTDPSKV X X -AKT1 Akt1 P31749 human SUMO1 7341 P63165 SUMO1 human T76 15178384 QrIADNHtPkELGME Rad60-SLD X X -AKT1 Akt1 P31749 human BRF1 677 Q07352 ZFP36L1 human S92 470147 RFRDRsFsEGGERLL Tis11B_N X X -AKT1 Akt1 P31749 human RNF11 26994 Q9Y3C5 RNF11 human T135 2893400 DWLMRSFtCPSCMEP zf-RING_2 X -AKT1 Akt1 P31749 human ULK1 22241 O70405 Ulk1 mouse S774 4699305 STRTRMFsVGsSSsL X -AKT1 Akt1 P31749 human SFRS3 6428 P84103 SRSF3 human S130 6421240 RsRsRsLsRDRRRER X -AKT1 Akt1 P31749 human FLNC 2318 Q14315 FLNC human S2233 467899 LGRERLGsFGsItRQ Filamin X -AKT1 Akt1 P31749 human CENTB1 9744 Q15027 ACAP1 human S554 458238 sIRPRPGsLRSkPEP X X -AKT1 Akt1 P31749 human PHF20 51230 Q9BVI0 PHF20 human S291 23303200 ELRRRKIsKGCEVPL X X -AKT1 Akt1 P31749 human USP4 7375 Q13107 USP4 human S445 5204831 NHRLRNDsVIVDTFH UCH X X -AKT1 Akt1 P31749 human PRSS15 9361 P36776 LONP1 human S181 1869121003 NESDVVEsLDEIyHT LON_substr_bdg X X -AKT1 Akt1 P31749 human NMDAR2C 24411 Q00961 Grin2c rat S1083 7979604 GPRPRHAsLPSSVAE X X -AKT1 Akt1 P31749 human SP1 6667 P08047 SP1 human S42 3180261 FsQARSSsTGsSSSt X X -AKT1 Akt1 P31749 human AML3 860 Q13950 RUNX2 human S196 27728401 GRSGRGKsFtLtITV Runt X -AKT1 Akt1 P31749 human p57Kip2 1028 P49918 CDKN1C human S282 9318134 FFAkRKRsAPEKSSG X X -AKT1 Akt1 P31749 human NQO1 1728 P15559 NQO1 human T128 1868914500 FIGEFAytyAAMyDk Flavodoxin_2 X X -AKT1 Akt1 P31749 human TSC2 24855 P49816 Tsc2 rat S1130 448499 GARDRVRsMsGGHGL X -AKT1 Akt1 P31749 human FOXO4 4303 P98177 FOXO4 human T32 455572 QsRPRsCtWPLPRPE X X 2599 -AKT1 Akt1 P31749 human eNOS 287024 P29473 NOS3 cow S617 448656 SYKIRFNsVSCSDPL Flavodoxin_1 X -AKT1 Akt1 P31749 human Mad1 4084 Q05195 MXD1 human S145 2807903 IERIRMDsIGSTVSS X X -AKT1 Akt1 P31749 human cytohesin 3 19159 O08967 Cyth3 mouse S155 25585001 ALRQFLWsFRLPGEA Sec7 X X -AKT1 Akt1 P31749 human beclin 1 8678 Q14457 BECN1 human S295 27156801 FRLGRLPsVPVEWNE APG6 X X -AKT1 Akt1 P31749 human RBM8A 9939 Q9Y5S9 RBM8A human S168 456535 GGRRRsRsPDRRRR_ X -AKT1 Akt1 P31749 human YB-1 4904 P67809 YBX1 human S102 455636 NPRKyLrsVGDGEtV CSD X X 2900 -AKT1 Akt1 P31749 human MDM2 4193 Q00987 MDM2 human S186 448131 RQRkRHksDsIsLsF X X -AKT1 Akt1 P31749 human SOX2 6657 P48431 SOX2 human T116 17490601 KYRPRRktktLMkKD SOXp X X -AKT1 Akt1 P31749 human AMPKA1 5562 Q13131 PRKAA1 human S496 450431 AtPQRsGsVsNyRSC AdenylateSensor X 4185; 4184; 2537 -AKT1 Akt1 P31749 human JARID1A 5927 P29375 KDM5A human S1255 56630502 CLTERAMsWQDRARQ X -AKT1 Akt1 P31749 human GATA2 2624 P23769 GATA2 human S401 455583 QTRNRKMsNKSKKSK X -AKT1 Akt1 P31749 human CCNF 899 P41002 CCNF human S577 234613503 TKRKRENsLQEDRGS X X -AKT1 Akt1 P31749 human FAK 5747 Q05397 PTK2 human S695 25291278 EERMRMEsRRQAtVs X X -AKT1 Akt1 P31749 human ADRB2 154 P07550 ADRB2 human S346 447911 LLCLRRssLKAyGNG X X -AKT1 Akt1 P31749 human acinus 305884 E9PST5 Acin1 rat S1329 456760 HSRSRsRsTPVRDRG X -AKT1 Akt1 P31749 human USP14 9097 P54578 USP14 human S432 31083558 THQGRSSsSGHyVSW UCH X X -AKT1 Akt1 P31749 human GR 2908 P04150 NR3C1 human S134 3178932 ANLNRstsVPENPkS GCR X X 85060 -AKT1 Akt1 P31749 human PKM 5315 P14618 PKM human S97 27110058 NVrtAtEsFAsDPIL PK X -AKT1 Akt1 P31749 human CTNNB1 12387 Q02248 Ctnnb1 mouse S552 472273 QDTQRRtsMGGtQQQ X X 9566; 5651 -AKT1 Akt1 P31749 human HES5 388585 Q5TA89 HES5 human S35 1867750500 RRDRINssIEQLKLL HLH X -AKT1 Akt1 P31749 human PDCD4 27250 Q53EL6 PDCD4 human S457 458382 RGRKRFVsEGDGGRL X X -AKT1 Akt1 P31749 human RPL13 6137 P26373 RPL13 human S106 480036 DPrRRNkstEsLQAN Ribosomal_L13e X -AKT1 Akt1 P31749 human VCP 7415 P55072 VCP human S352 457556 AAtNRPNsIDPALRR AAA X X -AKT1 Akt1 P31749 human CBP 1387 Q92793 CREBBP human T1871 474502 LMRRRMAtMNtRNVP X X -AKT1 Akt1 P31749 human AML3 860 Q13950 RUNX2 human T198 27728402 SGRGKsFtLtITVFT Runt X -AKT1 Akt1 P31749 human ZNF322A 79692 Q6U7Q0 ZNF322 human S224 114810402 EKSYRHRsAFIVHKR zf-C2H2 X X -AKT1 Akt1 P31749 human COPS6 10980 Q7L5N1 COPS6 human S60 27166600 DHWIRMRsQEGRPVQ JAB X X -AKT1 Akt1 P31749 human EDC3 80153 Q96F86 EDC3 human S161 1211074 sFRRRHNsWssssRH Edc3_linker X -AKT1 Akt1 P31749 human eNOS 24600 Q62600 Nos3 rat S1176 447884 TSRIRtQsFsLQERQ X 9570 -AKT1 Akt1 P31749 human AMPKA1 65248 P54645 Prkaa1 rat S496 450431 AtPQRSGsISNYRSC AdenylateSensor X 4185; 4184; 2537 -AKT1 Akt1 P31749 human DNAJC5 79130 P60905 Dnajc5 rat S10 448129 DQRQRsLsTsGEsLY X X -AKT1 Akt1 P31749 human PIK3R6 146850 Q5UE93 PIK3R6 human T607 10799542 SHRPREVtVsLRAtG PI3K_1B_p101 X -AKT1 Akt1 P31749 human GSK3A 606496 Q2NL51 Gsk3a mouse S21 448584 sGRARtssFAEPGGG X 9337; 9316; 9331; 9327; 8452; 8566 -AKT1 Akt1 P31749 human ITCH 83737 Q96J02 ITCH human S257 83110609 PsRPPRPsRPPPPTP X X -AKT1 Akt1 P31749 human PANK2 80025 Q9BZ23 PANK2 human S189 478697 TRRDRLGsysGPtsV X X -AKT1 Akt1 P31749 human TKT 7086 P29401 TKT human T382 34711200 GCATRNRtVPFCsTF Transket_pyr X -AKT1 Akt1 P31749 human FANCA 2175 O15360 FANCA human S1149 9802800 CLRSRDPsLMVDFIL X -AKT1 Akt1 P31749 human CDCA7 83879 Q9BWT1 CDCA7 human T163 4774845 SRRPRRRtFPGVASR X X -AKT1 Akt1 P31749 human HIST1H2BJ 8970 P06899 H2BC11 human S36 23113177 RKRSRkEsysIyVyk Histone X -AKT1 Akt1 P31749 human BAD 12015 Q61337 Bad mouse S112 447860 ETRsRHssyPAGtEE Bcl-2_BAD X 9291; 5284; 9296; 5193; 11865; 94223 -AKT1 Akt1 P31749 human TRF1 7013 P54274 TERF1 human T358 12115364 KKESRRAtESRIPVS X X -AKT1 Akt1 P31749 human p300 2033 Q09472 EP300 human S1834 447591 MLRRRMAsMQRTGVV X X -AKT1 Akt1 P31749 human THOC4 10189 Q86V81 ALYREF human T219 4614100 GGGtrRGtRGGARGR FoP_duplication X X -AKT1 Akt1 P31749 human BAP37 11331 Q99623 PHB2 human S91 22342307 RARPRkIssPTGSkD Band_7 X X -AKT1 Akt1 P31749 human METTL1 4234 Q9UBP6 METTL1 human S27 3627513 YYRQrAHsNPMADHT X X -AKT1 Akt1 P31749 human Bcl-10 8915 O95999 BCL10 human S231 469573 PLRsRtVsRQ_____ X -AKT1 Akt1 P31749 human CREB iso1 81646 P15337-1 Creb1 rat S133 448228 EILsRRPsYRkILND pKID X X 9187; 9196; 9198; 4095; 14228; 14001; 39561; 80120; 44864; 54960; 95995 -AKT1 Akt1 P31749 human GJA1 2697 P17302 GJA1 human S373 459209 RAssRAssRPRPDDL X X -AKT1 Akt1 P31749 human MDM2 17246 P23804 Mdm2 mouse S163 448130 SSRRRsIsEtEENTD X 3521 -AKT1 Akt1 P31749 human RAF1 5894 P04049 RAF1 human S259 447741 sQRQRststPNVHMV X 9421; 20011 -AKT1 Akt1 P31749 human lamin A/C 16905 P48678 Lmna mouse S404 478681 RsRGRAssHssQsQG X -AKT1 Akt1 P31749 human TSC2 7249 P49815 TSC2 human S981 454014 AFRCRSIsVSEHVVR X -AKT1 Akt1 P31749 human TSC2 24855 P49816 Tsc2 rat T1466 448546 GLRPRGYtISDSAPS X 3617; 3611 -AKT1 Akt1 P31749 human FOXO1A 2308 Q12778 FOXO1 human S256 448075 sPrRrAAsMDNNskF X X 9461; 84192 -AKT1 Akt1 P31749 human SSH1 54434 Q8WYL5 SSH1 human T826 35524905 AGLVRKHtKELERLK X X -AKT1 Akt1 P31749 human IKKA 1147 O15111 CHUK human T23 447780 EMRERLGtGGFGNVC Pkinase X X -AKT1 Akt1 P31749 human SH3RF1 59009 Q69ZI1 Sh3rf1 mouse S304 482847 KNTRKRHsFTSLTMA X -AKT1 Akt1 P31749 human CABLES1 91768 Q8TDN4 CABLES1 human T309 4270180 APLRRCRtLsGsPRP X X -AKT1 Akt1 P31749 human INVS 27130 Q9Y283 INVS human T864 55578722 SGARRLEtstLSEDF X X -AKT1 Akt1 P31749 human ephexin-1 25791 Q8N5V2 NGEF human S18 34499273 KTRRKsAsDQWNTDN X -AKT1 Akt1 P31749 human TRF1 7013 P54274 TERF1 human T273 6417401 sKRTRtItSQDKPSG X X -AKT1 Akt1 P31749 human GOLGA3 269682 P55937 Golga3 mouse S174 487482 VKRHRERsSQPAtKM X -AKT1 Akt1 P31749 human CENTG1 iso2 116986 Q99490-2 AGAP2 human S472 477808 RNLARALsTDCTPSG X X -AKT1 Akt1 P31749 human SIRT6 51548 Q8N6T7 SIRT6 human S338 7916000 PKRERPtsPAPHRPP X X -AKT1 Akt1 P31749 human GSK3B 56637 Q9WV60 Gsk3b mouse S9 449111 SGRPRttsFAEsCKP X X 9336; 9331; 9327; 9323; 9322; 9325; 5558; 8566; 79774; 8466; 25462; 14026; 14332; 14310; 14630 -AKT1 Akt1 P31749 human BAP37 11331 Q99623 PHB2 human S176 31828200 TERAKDFsLILDDVA Band_7 X X -AKT1 Akt1 P31749 human ACLY 47 P53396 ACLY human T447 455371 NAsGststPAPsRtA X -AKT1 Akt1 P31749 human MST1 6789 Q13043 STK4 human T387 450050 tMKRRDEtMQPAKPs X X -AKT1 Akt1 P31749 human AS160 9882 O60343 TBC1D4 human S570 455923 AKRsLtssLENIFsr X -AKT1 Akt1 P31749 human YAP1 10413 P46937 YAP1 human S127 448847 PQHVRAHssPAsLQL X X 4911; 13008; 92367; 57706 -AKT1 Akt1 P31749 human NBA1 29086 Q9NWV8 BABAM1 human S29 479974 EPRPRtRsNPEGAED X X 12110 -AKT1 Akt1 P31749 human RED1 104 P78563 ADARB1 human T553 31884906 LQGERLLtMSCSDKI A_deamin X X -AKT1 Akt1 P31749 human TBC1D1 23216 Q86TI0 TBC1D1 human T596 1247778 AFRRRANtLsHFPIE X -AKT1 Akt1 P31749 human VCP 7415 P55072 VCP human S746 457557 AMRFARRsVsDNDIr Vps4_C X X -AKT1 Akt1 P31749 human ACLY 47 P53396 ACLY human S451 455372 ststPAPsRtAsFsE X -AKT1 Akt1 P31749 human MKK4 6416 P45985 MAP2K4 human S80 447655 IERLRtHsIESSGkL X X 9155 -AKT1 Akt1 P31749 human p27Kip1 12576 P46414 Cdkn1b mouse S10 447874 NVRVsNGsPsLERMD X -AKT1 Akt1 P31749 human TIFA 92610 Q96CG3 TIFA human T9 50409900 tSFEDADtEEtVTCL X -AKT1 Akt1 P31749 human p21Cip1 114851 Q64315 Cdkn1a rat S146 447836 GRKRRQtsLTDFYHS X -AKT1 Akt1 P31749 human TERT 7015 O14746 TERT human S824 11418801 AVRIRGKsYVQCQGI RVT_1 X -AKT1 Akt1 P31749 human Merlin 4771 P35240 NF2 human S518 448282 DTDMKRLsMEIEKEK ERM_C X 9163; 13281 -AKT1 Akt1 P31749 human RARG iso2 19411 P18911-2 Rarg mouse S379 1869601000 ITDLRGIsTKGAERA Hormone_recep X -AKT1 Akt1 P31749 human TBC1D1 57915 Q60949 Tbc1d1 mouse S660 2228809 PRLNPSAssPNFFKY X 6928 -AKT1 Akt1 P31749 human EIF4B 75705 Q8BGD9 Eif4b mouse S422 451290 RERsRtGsEssQtGA X 3591 -AKT1 Akt1 P31749 human p21Cip1 12575 P39689 Cdkn1a mouse S141 447836 GRKRRQtsLTDFYHS X -AKT1 Akt1 P31749 human RARG 5916 P13631 RARG human S371 62884000 YARRRRPsQPYMFPR Hormone_recep X -AKT1 Akt1 P31749 human AR 367 P10275 AR human S215 448577 SGRAREAsGAPtsSK Androgen_recep X X -AKT1 Akt1 P31749 human DLC1 10395 Q96QB1 DLC1 human S766 458383 VTRTRsLsACNKRVG X X -AKT1 Akt1 P31749 human TBC1D1 57915 Q60949 Tbc1d1 mouse T590 1247778 AFRRRANtLsHFPVE X -AKT1 Akt1 P31749 human PFKFB3 5209 Q16875 PFKFB3 human S461 448801 NPLMRRNsVtPLAsP X X -AKT1 Akt1 P31749 human UBC9 7329 P63279 UBE2I human T35 18914511 PTKNPDGtMNLMNWE UQ_con X X -AKT1 Akt1 P31749 human p21Cip1 1026 P38936 CDKN1A human T145 447837 QGRkRRQtsMTDFyH X X -AKT1 Akt1 P31749 human EphA2 1969 P29317 EPHA2 human S897 1244153 RVsIRLPstsGsEGV X 16662; 6347 -AKT1 Akt1 P31749 human MDM2 4193 Q00987 MDM2 human S188 453413 RkRHksDsIsLsFDE X X -AKT1 Akt1 P31749 human FAK 5747 Q05397 PTK2 human T700 485788 MEsRRQAtVsWDsGG X X -AKT1 Akt1 P31749 human RPS3A 6189 P61247 RPS3A human T10 31828206 VGKNKRLtKGGKKGA X -AKT1 Akt1 P31749 human CFLAR 8837 O15519 CFLAR human S273 7590800 LLRDTFTsLGYEVQK Peptidase_C14 X -AKT1 Akt1 P31749 human H2B 3018 P33778 H2BC3 human S36 449903 RKRsRkEsysIyVyk Histone X -AKT1 Akt1 P31749 human FOXO1A 2308 Q12778 FOXO1 human T24 448560 LPRPRsCtWPLPRPE X X 2599; 9464 -AKT1 Akt1 P31749 human DNMT1 1786 P26358 DNMT1 human S143 3189394 RtPRRsksDGEAkPE X X -AKT1 Akt1 P31749 human nNOS 18125 Q9Z0J4 Nos1 mouse S1412 449830 TNRLRSEsIAFIEES X -AKT1 Akt1 P31749 human SCYL1 57410 Q96KG9 SCYL1 human T469 33402213 sTRHRVLtSAFSRAT X X -AKT1 Akt1 P31749 human cytohesin 2 9266 Q99418 CYTH2 human T276 30306600 LGGGRVKtWKRRWFI PH X -AKT1 Akt1 P31749 human EYA1 2138 Q99502 EYA1 human S299 41156500 SDRLRRGsDGKsRGR X -AKT1 Akt1 P31749 human TAL1 6886 P17542 TAL1 human T90 457536 EARHRVPttELCRPP X X -AKT1 Akt1 P31749 human BAD 572 Q92934 BAD human S99 447862 PFrGrsRsAPPNLWA Bcl-2_BAD X X 9295; 5286; 4366 -AKT1 Akt1 P31749 human PFKFB2 5208 O60825 PFKFB2 human S483 452046 IRRPRNysVGsRPLK X X 13064 -AKT1 Akt1 P31749 human NIBAN1 116496 Q9BZQ8 NIBAN1 human S602 467580 AsPARRAsAILPGVL X X -AKT1 Akt1 P31749 human CENTG1 iso2 116986 Q99490-2 AGAP2 human S629 4719772 THLSRVRsLDLDDWP ArfGap X X -AKT1 Akt1 P31749 human hnRNP A1 3178 P09651 HNRNPA1 human S199 451555 sQrGrsGsGNFGGGr X X -AKT1 Akt1 P31749 human CS 12974 Q9CZU6 Cs mouse S225 4774521 RNLYREGssIGAIDs Citrate_synt X -AKT1 Akt1 P31749 human SMAD3 4088 P84022 SMAD3 human T179 451177 PQSNIPEtPPPGYLS X -AKT1 Akt1 P31749 human PTP1B 5770 P18031 PTPN1 human S50 447811 RNRyRDVsPFDHsRI Y_phosphatase X X -AKT1 Akt1 P31749 human Akt1 207 P31749 AKT1 human S246 460649 LSRERVFsEDRARFY Pkinase X -AKT1 Akt1 P31749 human NCL 4691 P19338 NCL human T641 21697920 EIDGNkVtLDWAkPK RRM_1 X -AKT1 Akt1 P31749 human RPL7A 6130 P62424 RPL7A human T106 31828203 AHkYRPEtkQEKKQR X -AKT1 Akt1 P31749 human p47phox 653361 P14598 NCF1 human S304 449406 GAPPRRssIRNAHsI NECFESHC X -AKT1 Akt1 P31749 human TFEB 21425 Q9R210 Tfeb mouse S466 4785142 KAssRRssFsMEEGD DUF3371 X -AKT1 Akt1 P31749 human Nur77 3164 P22736 NR4A1 human S351 447942 GRRGRLPsKPKQPPD X X 5095 -AKT1 Akt1 P31749 human Huntingtin 3064 P42858 HTT human S419 448106 GGRsRsGsIVELIAG X X -AKT1 Akt1 P31749 human USP8 84092 Q80U87 Usp8 mouse T907 475072 TCRRRSRtFEAFMYL UCH X -AKT1 Akt1 P31749 human VCP 7415 P55072 VCP human S748 457558 RFARRsVsDNDIrky Vps4_C X X -AKT1 Akt1 P31749 human FBXW7 55294 Q969H0 FBXW7 human S227 17792400 QQRRRITsVQPPTGL X -AKT1 Akt1 P31749 human Ron 4486 Q04912 MST1R human S1394 450270 VRRPRPLsEPPRPT_ X X -AKT1 Akt1 P31749 human ENaC-alpha 25122 P37089 Scnn1a rat S621 454020 RFRsRYWsPGRGARG X -AKT1 Akt1 P31749 human VDAC2 7417 P45880 VDAC2 human S48 25316247 DVKtksCsGVEFSts Porin_3 X -AKT1 Akt1 P31749 human RAC1 5879 P63000 RAC1 human S71 447994 yDRLRPLsYPQTDVF Ras X 2461 -AKT1 Akt1 P31749 human GSK3A 2931 P49840 GSK3A human S21 448584 sGrARtssFAEPGGG X 9337; 9316; 9331; 5090; 9327; 8452; 8566 -AKT1 Akt1 P31749 human FOXO4 54601 Q9WVH3 Foxo4 mouse S197 448516 APRRRAAsMDSSSKL X 9471 -AKT1 Akt1 P31749 human WHSC1 7468 O96028 NSD2 human S172 478693 ARRNRKRsIKyDsLL X X -AKT1 Akt1 P31749 human HSP27 3315 P04792 HSPB1 human S82 448403 RALsRQLssGVsEIr X X 2406; 2401; 9709; 11892; 64293 -AKT1 Akt1 P31749 human NHE3 100009430 P26432 NHE-3 rabbit S515 31839901 NFDRRFLsKLLMRQs X X -AKT1 Akt1 P31749 human ATASE 5471 Q06203 PPAT human T397 1868225800 DSIVRGNtIsPIIkL Pribosyltran X -AKT1 Akt1 P31749 human USP35 57558 Q9P2H5 USP35 human S613 3214749 CRRRRLGsVMRPTED UCH X -AKT1 Akt1 P31749 human TTC3 7267 P53804 TTC3 human S378 12473003 AYTPRsLsAPIFTTS X X -AKT1 Akt1 P31749 human PLD2 5338 O14939 PLD2 human T175 1993000 NyLNRLLtMSFyRNY PX X -AKT1 Akt1 P31749 human BMI1 12151 P25916 Bmi1 mouse S314 6150348 ASRPRKssLNGSSAT X -AKT1 Akt1 P31749 human MDM4 4194 O15151 MDM4 human S367 457676 PDCRRtIsAPVVRPk X X -AKT1 Akt1 P31749 human CARD11 84433 Q9BXL7 CARD11 human S558 4737145 MQPPRsRssIMsITA X -AKT1 Akt1 P31749 human ARHGAP22 58504 Q7Z5H3 ARHGAP22 human S16 22262003 ARRARsKsLVMGEQS X -AKT1 Akt1 P31749 human NHE1 6548 P19634 SLC9A1 human S648 3880766 KTRQRLRsYNRHtLV NEXCaM_BD X -AKT1 Akt1 P31749 human PIKFYVE iso1 18711 Q9Z1T6-1 Pikfyve mouse S318 457532 PARNRsAsITNLSLD X -AKT1 Akt1 P31749 human Btk 695 Q06187 BTK human T495 28710301 EMRHRFQtQQLLEMC PK_Tyr_Ser-Thr X -AKT1 Akt1 P31749 human eNOS 4846 P29474 NOS3 human S615 448656 SYKIRFNsISCSDPL Flavodoxin_1 X -AKT1 Akt1 P31749 human HK2 3099 P52789 HK2 human T473 28704601 QHRARQktLEHLQLS Hexokinase_1 X -AKT1 Akt1 P31749 human THOC4 10189 Q86V81 ALYREF human S34 4614101 RGRGrAGsQGGrGGG X -AKT1 Akt1 P31749 human SKP2 6502 Q13309 SKP2 human S72 480507 PPRkRLkskGsDkDF X -AKT1 Akt1 P31749 human Akt1 207 P31749 AKT1 human T72 460648 tERPRPNtFIIRCLQ PH X -AKT1 Akt1 P31749 human JARID1A 5927 P29375 KDM5A human S287 56630503 RQRKGtLsVNFVDLY X -AKT1 Akt1 P31749 human TSC2 7249 P49815 TSC2 human T1462 448546 GLrPrGytISDsAPs X X 3617; 3611 -AKT1 Akt1 P31749 human TRBP 6895 Q15633 TARBP2 human S283 27457469 ILSLRsCsLGsLGAL X -AKT1 Akt1 P31749 human PKM 5315 P14618 PKM human S37 476070 MCRLDIDsPPItARN X -AKT1 Akt1 P31749 human lamin A/C 4000 P02545 LMNA human S404 478681 RsRGRAssHssQtQG X X -AKT1 Akt1 P31749 human BRCA1 672 P38398 BRCA1 human T509 448039 LKRKRRPtsGLHPED X X -AKT1 Akt1 P31749 human CASP9 842 P55211 CASP9 human S196 448454 kLRRRFssLHFMVEV Peptidase_C14 X X -AKT1 Akt1 P31749 human girdin 55704 Q3V6T2 CCDC88A human S1417 456477 INRERQksLtLtPTR X X -AKT1 Akt1 P31749 human mTOR 2475 P42345 MTOR human T2446 450853 NKRsRtRtDsysAGQ X -AKT1 Akt1 P31749 human ERR3 26381 P62509 Esrrg mouse S179 36400701 ITKRRRKsCQACRFM zf-C4 X -AKT1 Akt1 P31749 human FLI 2314 Q13045 FLII human S436 470489 RLRRRKDsAQDDQAK X -AKT1 Akt1 P31749 human NHE1 6548 P19634 SLC9A1 human S796 460570 QRIQRCLsDPGPHPE X -AKT1 Akt1 P31749 human ZRANB1 54764 Q9UGI0 ZRANB1 human S78 1105513501 SARPRVksSYSMENA X X -AKT1 Akt1 P31749 human ASK1 4217 Q99683 MAP3K5 human S83 447735 ATRGRGssVGGGSrR X X 3761 -AKT1 Akt1 P31749 human HTRA2 27429 O43464 HTRA2 human S212 477180 RVRVRLLsGDTYEAV Trypsin_2; Peptidase_M50 X X -AKT1 Akt1 P31749 human NDRG2 57447 Q9UN36 NDRG2 human T348 451009 GNRsRsRtLsQssEs X -AKT1 Akt1 P31749 human Bcl-10 8915 O95999 BCL10 human S218 469572 EEGTCANsSEMFLPL X -AKT1 Akt1 P31749 human USP33 23032 Q8TEY7 USP33 human T185 1883930900 ELRARGLtGLKNIGN X -AKT1 Akt1 P31749 human DTNBP1 94245 Q91WZ8 Dtnbp1 mouse S11 480124 TLRERLLsVQQDFTS X X -AKT1 Akt1 P31749 human DLC1 58834 Q63744 Dlc1 rat S330 458383 VTRTRSLsTCNKRVG X X -AKT1 Akt1 P31749 human PFKFB2 287019 P26285 PFKFB2 cow S484 452046 IRRPRNYsVGSRPLQ X -AKT1 Akt1 P31749 human METTL1 17299 Q9Z120 Mettl1 mouse S21 3627513 YYRQRAHsNPMADHT X -AKT1 Akt1 P31749 human eNOS 4846 P29474 NOS3 human S1177 447884 TSRIRtQsFsLQERQ X X 9571; 9570 -AKT1 Akt1 P31749 human CREB 1385 P16220 CREB1 human S119 448228 EILsRRPsyRkILND pKID X 9187; 9196; 9198; 4095; 14228; 14001; 39561; 80120; 44864; 54960; 95995 -AKT1 Akt1 P31749 human hnRNP E1 23983 P60335 Pcbp1 mouse S43 13258708 VKRIREEsGARINIs KH_1 X -AKT1 Akt1 P31749 human N-CoR1 9611 O75376 NCOR1 human S1450 1210494 tVRSRHtsVVsSGPs X X -AKT1 Akt1 P31749 human RAB3IP 117177 Q96QF0 RAB3IP human S165 472425 LSRLRsPsVLEVREK X X -AKT1 Akt1 P31749 human PCGF2 7703 P35227 PCGF2 human T334 34606690 TSRGRKMtVNGAPVP X X -AKT1 Akt1 P31749 human ITGB3 3690 P05106 ITGB3 human T779 470104 LyKEAtstFTNItyR Integrin_b_cyt X -AKT1 Akt1 P31749 human LBR G1N806 LBR turkey S82 14575430 RSRsRsRsRsPGRPA X -AKT1 Akt1 P31749 human FOXO3A 294515 D3ZBQ1 Foxo3 rat S252 449108 APRRRAVsMDNSNkY X 9466; 13129 -AKT1 Akt1 P31749 human WT1 iso7 7490 P19544-7 WT1 human S67 56653434 GRRsRGAsGsEPQQM X X -AKT1 Akt1 P31749 human XIAP 331 P98170 XIAP human S87 450336 VGRHRKVsPNCRFIN BIR X X -AKT1 Akt1 P31749 human TSC2 7249 P49815 TSC2 human S939 448501 sFRARstsLNERPKs X 3615 -AKT1 Akt1 P31749 human SP1 6667 P08047 SP1 human S698 5262507 CPkRFMRsDHLskHI zf-C2H2 X X -AKT1 Akt1 P31749 human MLK3 4296 Q16584 MAP3K11 human T477 36324901 HVRRRRGtFKRSKLR X X -AKT1 Akt1 P31749 human GSK3B 2932 P49841 GSK3B human S9 449111 SGRPRttsFAEsCkP X X 9336; 9331; 9327; 9323; 9322; 9325; 5558; 8566; 79774; 8466; 25462; 14026; 14332; 14310; 14630 -AKT1 Akt1 P31749 human RPS3 6188 P23396 RPS3 human T70 15113600 GrrIrELtAVVQkRF KH_2 X X -AKT1 Akt1 P31749 human Kaiso 10009 Q86T24 ZBTB33 human T606 34353150 yLSDRSStIPAMkDD X -AKT1 Akt1 P31749 human ZRANB1 54764 Q9UGI0 ZRANB1 human T117 1105513502 QRRTRsPtESPQSSG X X -AKT1 Akt1 P31749 human NDRG2 57447 Q9UN36 NDRG2 human S332 451010 LsRsRtAsLtsAAsV X -AKT1 Akt1 P31749 human RPS3A 6189 P61247 RPS3A human S112 31828205 LTRDkMCsMVKKWQT Ribosomal_S3Ae X -AKT1 Akt1 P31749 human RANBP3 8498 Q9H6Z4 RANBP3 human S126 460735 VKRERtssLtQFPPs X X 9380 -AKT1 Akt1 P31749 human AS160 9882 O60343 TBC1D4 human S751 455924 EGRKRtsstCsNEsL X -AKT1 Akt1 P31749 human Merlin 4771 P35240 NF2 human T230 487468 AIRNKKGtELLLGVD FERM_C X -AKT1 Akt1 P31749 human TBC1D1 57915 Q60949 Tbc1d1 mouse T499 2228808 NRAKRsLtEsLEsIL X -AKT1 Akt1 P31749 human EZH2 2146 Q15910 EZH2 human S21 457606 CWRKRVKsEyMRLRQ X X -AKT1 Akt1 P31749 human IGPR-1 126259 Q96BF3 TMIGD2 human S220 14160579 GKDQRGQsIyStSFP X X -AKT1 Akt1 P31749 human AR 367 P10275 AR human S792 448415 CVRMRHLsQEFGWLQ Hormone_recep X X -AKT1 Akt1 P31749 human ephexin-1 25791 Q8N5V2 NGEF human S16 34501054 LEKTRRKsAsDQWNT X -AKT1 Akt1 P31749 human MDM2 4193 Q00987 MDM2 human S166 448130 SsRRRAIsEtEENsD X X 3521 -AKT1 Akt1 P31749 human cytohesin 3 19159 O08967 Cyth3 mouse T280 25585002 KLGGRVKtWKRRWFI PH X X -AKT1 Akt1 P31749 human PRAS40 84335 Q96B36 AKT1S1 human T246 470067 LPRPRLNtsDFQkLK PRAS X X 2640; 2997; 32263; 13175; 60202 -AKT1 Akt1 P31749 human AML3 860 Q13950 RUNX2 human T200 27728400 RGKsFtLtITVFTNP Runt X -AKT1 Akt1 P31749 human FOXO4 54601 Q9WVH3 Foxo4 mouse T32 455572 QSRPRSCtWPLPRPD X -AKT1 Akt1 P31749 human ARHGAP19 84986 Q14CB8 ARHGAP19 human S422 3196670 QkRARsRsFsGLIkR X -AKT1 Akt1 P31749 human IWS1 55677 Q96ST2 IWS1 human T721 1851496 QRRRMNstGGQtPRR X -AKT1 Akt1 P31749 human SOX2 20674 P48432 Sox2 mouse T118 17490601 kYRPRRktkTLMkKD SOXp X X -AKT1 Akt1 P31749 human TIE1 21846 Q06806 Tie1 mouse T794 50596802 LHRRRTFtYQSGSGE X X -AKT1 Akt1 P31749 human FBXO31 79791 Q5XUX0 FBXO31 human S33 485583 AETAAADsEPDtDPE X -AKT1 Akt1 P31749 human SLC7A11 23657 Q9UPY5 SLC7A11 human S26 470841 NVNGRLPsLGNkEPP X X -AKT1 Akt1 P31749 human FOXO3A 2309 O43524 FOXO3 human T32 448602 QsRPRsCtWPLQRPE X X 2599; 9464 -AKT1 Akt1 P31749 human CYCS 54205 P99999 CYCS human Y47 3416311 ktGQAPGysytAANk Cytochrom_C X X -AKT1 Akt1 P31749 human beclin 1 8678 Q14457 BECN1 human S234 27156802 AQyQREysEFkRQQL APG6_N X -AKT1 Akt1 P31749 human BAX 581 Q07812 BAX human S184 451017 VAGVLTAsLtIWKKM TM X -AKT1 Akt1 P31749 human RENT1 5976 Q92900 UPF1 human T151 50788283 FCNGRGNtSGSHIVN UPF1_Zn_bind X X -AKT1 Akt1 P31749 human AS160 9882 O60343 TBC1D4 human S341 455922 QPRRRHAsAPsHVQP PID X -AKT1 Akt1 P31749 human p27Kip1 1027 P46527 CDKN1B human T198 448781 PGLRRRQt_______ X X -AKT1 Akt1 P31749 human MYST3 7994 Q92794 KAT6A human T369 19008950 RGRKRKItLSSQSAS X X -AKT1 Akt1 P31749 human JARID1A 5927 P29375 KDM5A human T285 56630501 QMRQRKGtLsVNFVD X -AKT1 Akt1 P31749 human ACOT4 122970 Q8N9L9 ACOT4 human S392 1871177703 GGEPRAHskAQEDAW BAAT_C X X -AKT1 Akt1 P31749 human SIK 150094 P57059 SIK1 human T182 456034 kSGEPLStWCGSPPY Pkinase X -AKT1 Akt1 P31749 human TSC2 24855 P49816 Tsc2 rat S939 448501 KFRARSTsLNERPKS X 3615 -AKT1 Akt1 P31749 human acinus 22985 Q9UKV3 ACIN1 human S1180 456759 GPRsRsRsRDRRRKE RSB_motif X -AKT1 Akt1 P31749 human YB-1 4904 P67809 YBX1 human S209 7998039 YGrrPQysNPPVQGE X -AKT1 Akt1 P31749 human p300 328572 B2RWS6 Ep300 mouse S1733 1295500 PGDSRRLsIQRCIQS X X -AKT1 Akt1 P31749 human PRSS15 9361 P36776 LONP1 human S173 1869121004 VFLKRDDsNESDVVE LON_substr_bdg X X -AKT1 Akt1 P31749 human FOXO4 4303 P98177 FOXO4 human S197 448516 APRRRAAsMDsSSKL X X 9471 -AKT1 Akt1 P31749 human lamin A/C 60374 P48679 Lmna rat S301 480106 QSRIRIDsLSAQLSQ Filament X -AKT1 Akt1 P31749 human ZNF322A 79692 Q6U7Q0 ZNF322 human T262 10990183 IVHQRVHtGEkPYKC X X -AKT1 Akt1 P31749 human MST2 6788 Q13188 STK3 human T117 12615900 IIRLRNktLIEDEIA Pkinase X X -AKT1 Akt1 P31749 human peripherin 19132 P15331 Prph mouse S66 483953 sssArLGsFRAPRAG Filament_head X X -AKT1 Akt1 P31749 human ER-alpha 2099 P03372 ESR1 human S167 448102 GGRERLAsTNDkGSM Oest_recep X X 64508; 42101 -AKT1 Akt1 P31749 human FOXO1A 2308 Q12778 FOXO1 human S319 449113 TFRPRtssNAstIsG X X 2486 -AKT1 Akt1 P31749 human GABRB2 25451 P63138 Gabrb2 rat S434 449329 SRLRRRAsQLKITIP Neur_chan_memb X X -AKT1 Akt1 P31749 human MASTL 84930 Q96GX5 MASTL human T299 1269647500 QsRKRLAtSSAsSQS X -AKT1 Akt1 P31749 human TXNIP 56338 Q8BG60 Txnip mouse S309 277409200 GLSSRTSsMASRTSS X X -AKT1 Akt1 P31749 human CDK2 1017 P24941 CDK2 human T39 2712201 LkKIRLDtETEGVPs Pkinase X X -AKT1 Akt1 P31749 human FOXG1 2290 P55316 FOXG1 human T279 482881 KLRRRsttsRAKLAF X -AKT1 Akt1 P31749 human TBC1D1 57915 Q60949 Tbc1d1 mouse S621 2228806 RKLMRYHsVstETPH X -AKT1 Akt1 P31749 human BRAF 673 P15056 BRAF human S365 450243 GQRDRsssAPNVHIN X -AKT1 Akt1 P31749 human CARHSP1 23589 Q9Y2V2 CARHSP1 human S52 453062 tRRtrtFsAtVRAsQ X X -AKT1 Akt1 P31749 human NHERF 9368 O14745 NHERF1 human T156 3864004 ELRPRLCtMKKGPsG PDZ X X -AKT1 Akt1 P31749 human arfaptin 2 23647 P53365 ARFIP2 human S260 455884 GTRGRLEsAQATFQA Arfaptin X X -AKT1 Akt1 P31749 human PAPD4 167153 Q6PIY7 TENT2 human S116 50785745 LsGERRYsMPPLFHT X -AKT1 Akt1 P31749 human TBC1D7 51256 Q9P0N9 TBC1D7 human S124 15415675 GkLPRsPsFPLEPDD X X -AKT1 Akt1 P31749 human S6 6194 P62753 RPS6 human S236 448093 AKRRRLssLRAstsK X 5006; 4856; 4857; 4858; 4851; 4803; 2211; 3945; 3985; 5316; 4854; 8520; 48319; 40643; 9865; 38573; 14733; 27036; 34411; 62016; 62788; 81736; 97935; 99457; 15448 -AKT1 Akt1 P31749 human Chk1 1111 O14757 CHEK1 human S280 447831 AKRPRVtsGGVsEsP X X 2347 -AKT1 Akt1 P31749 human LBR G1N806 LBR turkey S80 14575427 SRRSRsRsRsRsPGR X -AKT1 Akt1 P31749 human SH3BP4 23677 Q9P0V3 SH3BP4 human S246 3214461 FRsKRsYsLsELsVL X -AKT1 Akt1 P31749 human GAB2 9846 Q9UQC2 GAB2 human S159 448382 LLRERKSsAPSHsSQ X X 3884 -AKT1 Akt1 P31749 human DRP1 10059 O00429 DNM1L human S616 454690 PIPIMPAsPQKGHAV X 3455; 4494; 63940 -AKT1 Akt1 P31749 human BRF1 677 Q07352 ZFP36L1 human S203 470146 PRLQHsFsFAGFPSA X -AKT1 Akt1 P31749 human ataxin-1 6310 P54253 ATXN1 human S775 449110 AtRKRRWsAPESRKL X X -AKT1 Akt1 P31749 human LARP6 55323 Q9BRS8 LARP6 human S451 485240 QEKsPGtsPLLsRKM X X -AKT1 Akt1 P31749 human ATP1A1 24211 P06685 Atp1a1 rat S943 451649 ICKTRRNsVFQQGMK Cation_ATPase_C X -AKT1 Akt1 P31749 human GJA1 24392 P08050 Gja1 rat S369 459208 RPssRAssRAssRPR X -AKT1 Akt1 P31749 human ASK1 26408 O35099 Map3k5 mouse S90 447735 ATRGRGNsGSGGGRR X -AKT1 Akt1 P31749 human DENND1A 227801 Q8K382 Dennd1a mouse S536 484447 PYRtLKEsDsAEGDE X -AKT1 Akt1 P31749 human PKM 5315 P14618 PKM human S202 15721963 tEVENGGsLGskkGV PK X -AKT1 Akt1 P31749 human WNK1 65125 Q9H4A3 WNK1 human T60 450948 EYRRRRHtMDKDSrG X X 4946 -AKT1 Akt1 P31749 human LTB4R2 56413 Q9NPC1 LTB4R2 human T324 12267086 GGRSREGtMELRTTP TM X X -AKT1 Akt1 P31749 human RSK2 6197 P51812 RPS6KA3 human T115 1880515604 KVRDRVRtKMERDIL X X -AKT1 Akt1 P31749 human PDE3A 54611 Q9Z0X4 Pde3a mouse S291 471416 WKRRRRsssVVAGEM X -AKT1 Akt1 P31749 human FLNA 2316 P21333 FLNA human S2152 451357 tRRRRAPsVANVGsH Filamin X 4761 -AKT1 Akt1 P31749 human AS160 9882 O60343 TBC1D4 human T642 455921 QFRRRAHtFsHPPss X X 4288; 8881 -AKT1 Akt1 P31749 human INVS 27130 Q9Y283 INVS human S865 55578721 GARRLEtstLSEDFQ X X -AKT1 Akt1 P31749 human Wee1 7465 P30291 WEE1 human S642 455381 KKMNRSVsLtIy___ X 4910 -AKT1 Akt1 P31749 human BRAF 673 P15056 BRAF human S429 447803 PQRERKsssssEDRN X -AKT1 Akt1 P31749 human Merlin 4771 P35240 NF2 human S10 1720901 GAIASRMsFSsLkRK X X -AKT1 Akt1 P31749 human CCT2 10576 P78371 CCT2 human S260 472352 GsRVRVDstAkVAEI Cpn60_TCP1 X X -AKT1 Akt1 P31749 human Cot 1326 P41279 MAP3K8 human S400 447712 EDQPRCQsLDSALLE X 4491 -AKT1 Akt1 P31749 human DLC1 10395 Q96QB1 DLC1 human S735 15499997 MVRKRsVsNstQtSS X X -AKT1 Akt1 P31749 human JARID1A 5927 P29375 KDM5A human T1225 56630500 SRRPRLEtILSLLVS X -AKT1 Akt1 P31749 human DJ-1 11315 Q99497 PARK7 human T125 1869992402 GFGSKVTtHPLAkDk DJ-1_PfpI X -AKT1 Akt1 P31749 human SP1 6667 P08047 SP1 human T679 25312143 ELQRHKRtHtGEkkF zf-C2H2 X X -AKT1 Akt1 P31749 human Vimentin 7431 P08670 VIM human S39 451766 ttstrtysLGsALrP Filament_head X X 13614 -AKT1 Akt1 P31749 human CARD11 84433 Q9BXL7 CARD11 human S644 457638 NLMFRKFsLERPFRP X -AKT1 Akt1 P31749 human TSC2 24855 P49816 Tsc2 rat S1132 448500 RDRVRsMsGGHGLRV X -AKT1 Akt1 P31749 human PANK2 80025 Q9BZ23 PANK2 human S169 478728 PLRRRAssAsVPAVG X X -AKT1 Akt1 P31749 human UBE2S 27338 Q16763 UBE2S human T152 58109405 AARARLLtEIHGGAG UQ_con X X -AKT1 Akt1 P31749 human AS160 9882 O60343 TBC1D4 human T568 486326 NKAKRsLtssLENIF X -AKT1 Akt1 P31749 human p47phox 653361 P14598 NCF1 human S328 449404 QDAYRRNsVRFLQQR NECFESHC X -AKT1 Akt1 P31749 human SFRS3 6428 P84103 SRSF3 human S122 6421062 SPRRRsFsRsRsRsL X -AKT1 Akt1 P31749 human SSB 6741 P05455 SSB human T389 477729 VKRAREEtDkEEPAS X X -AKT1 Akt1 P31749 human ZNF322A 79692 Q6U7Q0 ZNF322 human T150 1869121002 LVHQRSHtGEKPYLC X X -AKT1 Akt1 P31749 human Bcl-3 602 P20749 BCL3 human S41 27444668 kRPLRAPsPEPAAPR X -AKT1 Akt1 P31749 human AS160 9882 O60343 TBC1D4 human S588 455920 RMRGRLGsVDsFERs X X 8730 -AKT1 Akt1 P31749 human HSP70 3303 P0DMV8 HSPA1B human S631 483567 AQGPkGGsGsGPtIE X X -AKT1 Akt1 P31749 human eNOS 287024 P29473 NOS3 cow S1179 447884 TSRIRtQsFsLQERH X X 9570 -AKT1 Akt1 P31749 human DENND1A 227801 Q8K382 Dennd1a mouse S538 484448 RtLKEsDsAEGDETE X -AKT1 Akt1 P31749 human E2A iso2 21423 P15806-2 Tcf3 mouse S527 483180 VPRtRtsstDEVLsL X -AKT1 Akt1 P31749 human p27Kip1 1027 P46527 CDKN1B human S10 447874 NVRVSNGsPsLErMD X X -AKT1 Akt1 P31749 human CCNF 899 P41002 CCNF human T31 234613504 RRRPRNLtILSLPED X X -AKT1 Akt1 P31749 human Sin1 79109 Q9BPZ7 MAPKAP1 human T86 3253548 GIRRRsNtAQRLERL SIN1 X 14716 -AKT1 Akt1 P31749 human MVD 4597 P53602 MVD human S96 476192 LARKRRNsRDGDPLP X -AKT1 Akt1 P31749 human SFRS3 6428 P84103 SRSF3 human S138 470451 RDRRRERsLsRERNH X -AKT1 Akt1 P31749 human CBX3 11335 Q13185 CBX3 human T89 31828201 AGkEkDGtKRksLsD X -AKT1 Akt1 P31749 human p21Cip1 114851 Q64315 Cdkn1a rat T145 447837 QGRKRRQtsLTDFYH X -AKT1 Akt1 P31749 human DLC1 10395 Q96QB1 DLC1 human S1004 34490415 RHRLRWHsFQSSHRP X X -AKT1 Akt1 P31749 human TKT 7086 P29401 TKT human S387 18503161 NRtVPFCsTFAAFFT Transket_pyr X -AKT1 Akt1 P31749 human JARID1A 5927 P29375 KDM5A human S225 36123496 TRRVkTQsESGDVSR X -AKT1 Akt1 P31749 human Zyxin 7791 Q15942 ZYX human S142 460644 PQPREKVssIDLEId X X 4863; 8467 -AKT1 Akt1 P31749 human FAF1 11124 Q9UNN5 FAF1 human S582 480070 kLRIRtPsGEFLERR UBX X X -AKT1 Akt1 P31749 human CBX3 11335 Q13185 CBX3 human T55 31828202 FLkWkGFtDADNtWE Chromo X -AKT1 Akt1 P31749 human RALGAPA2 57186 Q2PPJ7 RALGAPA2 human S486 485552 SsWGRTYsFtSAMsR X -AKT1 Akt1 P31749 human AS160 9882 O60343 TBC1D4 human S666 486327 GRAQGVRsPLLRQSS X -AKT1 Akt1 P31749 human RGC32 iso2 28984 Q9H4X1-2 RGCC human S45 6370305 ERMKRRSsAsVSDSS RGCC X -AKT1 Akt1 P31749 human Akt1 11651 P31750 Akt1 mouse S473 447855 RPHFPQFsysAsGtA Pkinase_C X 9271; 3787; 4060; 4051; 5102; 4058; 2336; 2337; 4075; 4070; 5012; 4071; 92982; 5315; 9563; 9018; 12694; 52240; 11962; 15116; 88106; 26580; 68035; 31957; 23430; 20235 -AKT1 Akt1 P31749 human TBC1D1 57915 Q60949 Tbc1d1 mouse T253 2228805 DASLRSStFssFDND X -AKT1 Akt1 P31749 human NPM1 4869 P06748 NPM1 human S48 14577038 QLsLrTVsLGAGAkD Nucleoplasmin X X -AKT1 Akt1 P31749 human KHSRP 8570 Q92945 KHSRP human S193 473552 GLPERsVsLtGAPEs KH_1 X -AKT1 Akt1 P31749 human PIP5K1C 23396 O60331 PIP5K1C human S555 1855423 RYRRRtQssGQDGRP X X -AKT1 Akt1 P31749 human CLK2 1196 P49760 CLK2 human T127 15339202 RRRRRSRtFSRSSSQ X X -AKT1 Akt1 P31749 human HES5 388585 Q5TA89 HES5 human S34 1867750501 MRRDRINssIEQLKL HLH X -AKT1 Akt1 P31749 human FOXO3A 294515 D3ZBQ1 Foxo3 rat T32 448602 QSRPRSCtWPLQRPE X 9464 -AKT1 Akt1 P31749 human NFAT90 3609 Q12906 ILF3 human S647 3496801 rGrGRGGsIRGRGRG X X -AKT1 Akt1 P31749 human SYTL1 84958 Q8IYJ3 SYTL1 human S241 456480 RMLsSSSsVSSLNSS X -AKT1 Akt1 P31749 human PGC-1 alpha 19017 O70343 Ppargc1a mouse S570 2045307 RMRSRsRsFsRHRSC X -AKT1 Akt1 P31749 human HuR 1994 Q15717 ELAVL1 human S100 474553 VSYARPSsEVIkDAN X X -AKT1 Akt1 P31749 human HSF1 3297 Q00613 HSF1 human S326 455484 ssVDtLLsPTALIDs Vert_HS_TF X X -AKT1 Akt1 P31749 human CTNNB1 1499 P35222 CTNNB1 human S552 472273 QDtQRRtsMGGtQQQ X X 9566; 5651 -AKT1 Akt1 P31749 human TWIST1 7291 Q15672 TWIST1 human S123 14821303 RERQRtQsLNEAFAA HLH X X -AKT1 Akt1 P31749 human PACS2 23241 Q86VP3 PACS2 human S437 480160 GRRGRStsLKERQAA X -AKT1 Akt1 P31749 human TSPYL5 85453 Q86VY4 TSPYL5 human T120 3245189 SERLAADtVFVGTAG X -AKT1 Akt1 P31749 human TERT 7015 O14746 TERT human S227 11418800 GARRRGGsASRSLPL X X -AKT1 Akt1 P31749 human GOLGA3 269682 P55937 Golga3 mouse S385 478659 EVRsRRDsICssVSM X -AKT1 Akt1 P31749 human EDG-1 1901 P21453 S1PR1 human T236 447691 RTRSRRLtFRKNISK 7tm_1 X X -AKT1 Akt1 P31749 human FOXO3A 56484 Q9WVH4 Foxo3 mouse T32 448602 QSRPRSCtWPLQRPE X 9464 -AKT1 Akt1 P31749 human NHEJ1 79840 Q9H9Q4 NHEJ1 human T181 35499302 LIRDRLktEPFEENS X X -AKT1 Akt1 P31749 human PDE3A 54611 Q9Z0X4 Pde3a mouse S292 471417 KRRRRsssVVAGEMS X -AKT1 Akt1 P31749 human HK2 15277 O08528 Hk2 mouse T473 28704601 QHRARQKtLESLKLS Hexokinase_1 X X -AKT1 Akt1 P31749 human lamin A/C 4000 P02545 LMNA human S301 480106 QsRIRIDsLsAQLsQ Filament X -AKT1 Akt1 P31749 human lamin A/C 60374 P48679 Lmna rat S404 478681 RSRGRAssHssQSQG X -AKT1 Akt1 P31749 human PIKFYVE 200576 Q9Y2I7 PIKFYVE human S318 3216759 LsLDRsGsPMVPSyE X -AKT1 Akt1 P31749 human ATG4B 23192 Q9Y4P1 ATG4B human S34 4750282 WILGRKYsIFTEkDE X -AKT1 Akt1 P31749 human SFRS3 6428 P84103 SRSF3 human S140 470452 RRRERsLsRERNHKP X -AKT1 Akt1 P31749 human RICTOR 253260 Q6R327 RICTOR human T1135 458276 NRRIRtLtEPsVDFN RICTOR_phospho X 3806 -AKT1 Akt1 P31749 human FOXA2 3170 Q9Y261 FOXA2 human T156 4911901 KTYRRSYtHAKPPYS Forkhead_N X -AKT1 Akt1 P31749 human PERK 13666 Q9Z2B5 Eif2ak3 mouse T799 11073906 YTRSREGtSSSIVFE X -AKT1 Akt1 P31749 human palladin 23022 Q8WX93 PALLD human S1118 468361 VRRPRsRsRDsGDEN X X -AKT1 Akt1 P31749 human PIKFYVE 200576 Q9Y2I7 PIKFYVE human S307 457532 PARNRsAsItNLsLD X X -AKT1 Akt1 P31749 human SH3RF1 57630 Q7Z6J0 SH3RF1 human S304 482847 KNTKKRHsFtsLtMA X -AKT1 Akt1 P31749 human HJURP 55355 Q8NCD3 HJURP human S486 482923 GLEtRRLsLPssKAK X -AKT1 Akt1 P31749 human ZNF322A 79692 Q6U7Q0 ZNF322 human T234 1246856 IVHKRVHtGEkPYKC X X -AKT1 Akt1 P31749 human PFKFB2 287019 P26285 PFKFB2 cow S467 448460 PVRMRRNsFTPLSSS X -AKT1 Akt1 P31749 human p300 328572 B2RWS6 Ep300 mouse S1833 447591 MLRRRMAsMQRTGVA X X -AKT1 Akt1 P31749 human AML3 860 Q13950 RUNX2 human S28 3053615 PSTsRRFsPPSssLQ X -AKT1 Akt1 P31749 human PAPD4 167153 Q6PIY7 TENT2 human S110 31880251 VNQIVPLsGERRYsM X -AKT1 Akt1 P31749 human IRS1 3667 P35568 IRS1 human S629 478346 VPsGRKGsGDyMPMs X X -AKT1 Akt1 P31749 human NCL 4691 P19338 NCL human T707 21697921 HKPQGKKtKFE____ X -AKT1 Akt1 P31749 human GJA1 24392 P08050 Gja1 rat S373 459209 RAssRAssRPRPDDL X -AKT1 Akt1 P31749 human Myt1 Q95YJ1 Pkmyt1 starfish S75 449752 ESRPRAVsFRQSEPS X X -AKT1 Akt1 P31749 human PDHK1 5163 Q15118 PDK1 human T346 13831355 APRPRVEtsRAVPLA HATPase_c X -AKT1 Akt1 P31749 human RPS3A 6189 P61247 RPS3A human T88 31828204 FRkFkLItEDVQGkN Ribosomal_S3Ae X -AKT1 Akt1 P31749 human HIST2H3A/C/D 126961 Q71DI3 H3C14 human T45 18465115 PHryrPGtVALrEIR Histone X -AKT1 Akt1 P31749 human BAD 12015 Q61337 Bad mouse S136 447862 PFRGRsRsAPPNLWA Bcl-2_BAD X X 9295; 5286; 4366 -AKT1 Akt1 P31749 human GATSL3 652968 Q8WTX7 CASTOR1 human S14 25293269 EHRVRVLsVARPGLW Castor1_N X X -AKT1 Akt1 P31749 human FOXO3A 2309 O43524 FOXO3 human S253 449108 APRRRAVsMDNSNkY X X 9466; 13129 -AKT1 Akt1 P31749 human PAR-4 64513 Q62627 Pawr rat S249 456965 SRHNRDTsAPANFAS ATG16; DUF724; DUF4164 X X -AKT1 Akt1 P31749 human SRPK2 6733 P78362 SRPK2 human T492 483237 PSHDRSRtVsAsstG X X -AKT1 Akt1 P31749 human NMDAR2C 14813 Q01098 Grin2c mouse S1084 7979604 GPRPRHAsLPSSVAE X -AKT1 Akt1 P31749 human GATA1 2623 P15976 GATA1 human S310 451231 QtRNRKAsGkGkkkR X X -AKT1 Akt1 P31749 human HSF1 3297 Q00613 HSF1 human T142 449066 DsVTKLLtDVQLMKG X -AKT1 Akt1 P31749 human H3 8350 P68431 H3C1 human T45 455679 PHryrPGtVALrEIR Histone X X -AKT1 Akt1 P31749 human SSB 20823 P32067 Ssb mouse T301 452110 LLRNKKVtWkVLEGH RRM_3 X -AKT1 Akt1 P31749 human PHB 18673 P67778 Phb1 mouse T258 11139253 LSRSRNItyLPAGQs X -AKT1 Akt1 P31749 human GSK3A 50686 P18265 Gsk3a rat S21 448584 SGRARtssFAEPGGG X 9337; 9316; 9331; 9327; 8452; 8566 -AKT1 Akt1 P31749 human NLRP3 114548 Q96P20 NLRP3 human S5 38492201 ___MKMAsTRCKLAR X -AKT1 Akt1 P31749 human Kv11.1 iso5 3757 Q12809_VAR_014388 KCNH2 human T897 4839200 SFRRRtDtDtEQPGE X -AKT1 Akt1 P31749 human ER-alpha 2099 P03372 ESR1 human S305 448805 IkRSkkNsLALSLtA X -AKT1 Akt1 P31749 human CK2A1 1457 P68400 CSNK2A1 human T13 31012808 PsRARVytDVNtHRP X X -AKT1 Akt1 P31749 human NQO1 1728 P15559 NQO1 human S40 23255660 kGWEVVEsDLyAMNF Flavodoxin_2 X -AKT1 Akt1 P31749 human DOCK6 57572 Q96HP0 DOCK6 human S1194 27806316 GQRsRLAsMLDSDTE X X -AKT1 Akt1 P31749 human Huntingtin 15194 P42859 Htt mouse S398 448106 RGRGRsGsIVELLAG X -AKT1 Akt1 P31749 human K8 3856 P05787 KRT8 human S432 448540 sAyGGLtsPGLsysL X -AKT1 Akt1 P31749 human IWS1 55677 Q96ST2 IWS1 human S720 477902 PQRRRMNstGGQtPR X -AKT1 Akt1 P31749 human NHE1 24782 P26431 Slc9a1 rat S652 3880766 KTRQRLRsYNRHTLV NEXCaM_BD X X -AKT1 Akt1 P31749 human EPRS 2058 P07814 EPRS1 human S999 9720900 NQGGGLsssGAGEGQ X X -AKT1 Akt1 P31749 human FLCN 201163 Q8NFG4 FLCN human S62 3206874 NSRMRAHsPAEGAsV X X -AKT1 Akt1 P31749 human H2B2F 440689 Q5QNW6 H2BC18 human S36 1210846 RKRsRkEsysVyVyk Histone X -AKT1 Akt1 P31749 human EMSY 56946 Q7Z589 EMSY human S209 453526 RKRRRtNsssssPVV X X -AKT1 Akt1 P31749 human IP3R1 25262 P29994 Itpr1 rat S2682 458310 FPRMRAMsLVSSDSE X X -AKT1 Akt1 P31749 human SH3BP4 98402 Q921I6 Sh3bp4 mouse S245 3214461 FRsKRsYsLSELsVL X X -AKT1 Akt1 P31749 human USP10 9100 Q14694 USP10 human T674 10801134 VEIsRRVtLEkLPPV UCH X X -AKT1 Akt1 P31749 human PEA-15 8682 Q15121 PEA15 human S116 450281 kDIIRQPsEEEIIKL X X -AKT1 Akt1 P31749 human RSK2 6197 P51812 RPS6KA3 human S19 7445513 KMAVEsPsDSAENGQ X X -AKT1 Akt1 P31749 human GATA1 14460 P17679 Gata1 mouse S310 451231 QTRNRkAsGkGKKkR X -AKT1 Akt1 P31749 human DBNL 28988 Q9UJU6 DBNL human S269 467729 KQKERAMsttsIssP X -AKT1 Akt1 P31749 human DBNL 28988 Q9UJU6 DBNL human T291 476604 PFLQkQLtQPEtHFG X -AKT1 Akt1 P31749 human cGAS 214763 Q8C6L5 Cgas mouse S291 36128853 VEKEKPGsPAVTLLI Mab-21 X X -AKT1 Akt1 P31749 human MAZ 4150 P56270 MAZ human T385 449095 kDRLRAHtVRHEEKV X X -AKT1 Akt1 P31749 human TFE3 209446 Q64092 Tfe3 mouse S565 455896 KAssRRssFsMEEES DUF3371 X X -AKT1 Akt1 P31749 human PLB 64672 P61016 Pln rat S16 448114 RSAIRRAstIEMPQQ Phospholamban X 8496 -AKT1 Akt1 P31749 human HMOX1 3162 P09601 HMOX1 human S188 2897404 LYRSRMNsLEMtPAV Heme_oxygenase X X -AKT1 Akt1 P31749 human RPS3 27050 P62908 Rps3 mouse T70 15113600 GRRIRELtAVVQkRF KH_2 X -AKT1 Akt1 P31749 human TIAM1 7074 Q13009 TIAM1 human S231 468938 sTCQRANsLGDLYAQ X X -AKT1 Akt1 P31749 human IRE1 78943 Q9EQY0 Ern1 mouse S724 7161100 KLAVGRHsFSRRsGV Pkinase X X -AKT1 Akt1 P31749 human PDE3A 54611 Q9Z0X4 Pde3a mouse S290 471415 GWKRRRRsssVVAGE X -RET Ret P07949 human Ret 5979 P07949 RET human Y981 450703 DNCSEEMyRLMLQCW PK_Tyr_Ser-Thr X X -RET Ret P07949 human FAK 5747 Q05397 PTK2 human Y925 447966 DRsNDkVyENVtGLV Focal_AT X 3284 -RET Ret P07949 human Ret 5979 P07949 RET human Y1090 450704 TNTGFPRyPNDSVyA X -RET Ret P07949 human ATF-4 468 P18848 ATF4 human T107 40420006 LGIDDLEtMPDDLLt X X -RET Ret P07949 human FAK 5747 Q05397 PTK2 human Y577 447890 yMEDstyyKAsKGKL PK_Tyr_Ser-Thr X X 3281 -RET Ret P07949 human ATF-4 468 P18848 ATF4 human T115 40420008 MPDDLLttLDDtCDL X X -RET Ret P07949 human JNK2 5601 P45984 MAPK9 human Y185 447652 tNFMMtPyVVtRYYR Pkinase X -RET Ret P07949 human Ret 5979 P07949 RET human Y1096 449891 RyPNDSVyANWMLSP X -RET Ret P07949 human JNK1 5599 P45983 MAPK8 human Y185 447645 tsFMMtPyVVtRYYR Pkinase X 5136; 4668; 4671; 9257; 9255; 9251; 4306; 5755; 16014; 58328 -RET Ret P07949 human PIK3R1 5295 P27986 PIK3R1 human Y203 25693200 PVIPAAVySEMIsLA RhoGAP X -RET Ret P07949 human Ret 5979 P07949 RET human Y826 449893 SRKVGPGyLGSGGSR PK_Tyr_Ser-Thr X -RET Ret P07949 human Ret 5979 P07949 RET human Y1015 449894 MMVKRRDyLDLAAST X -RET Ret P07949 human PDK1 5170 O15530 PDPK1 human Y9 447696 ARTTSQLyDAVPIQS X -RET Ret P07949 human ATF-4 468 P18848 ATF4 human T114 40420007 tMPDDLLttLDDtCD X X -RET Ret P07949 human DOK1 1796 Q99704 DOK1 human Y398 448369 ARVkEEGyELPyNPA X -RET Ret P07949 human Ret 5979 P07949 RET human Y809 450701 LIVEyAKyGSLRGFL PK_Tyr_Ser-Thr X -RET Ret P07949 human FAK 5747 Q05397 PTK2 human Y861 447965 PIGNQHIyQPVGKPD X -RET Ret P07949 human ATF-4 468 P18848 ATF4 human T119 40420009 LLttLDDtCDLFAPL X X -RET Ret P07949 human Ret 5979 P07949 RET human Y1029 449895 TPSDSLIyDDGLSEE X -RET Ret P07949 human Ret 5979 P07949 RET human Y687 449892 AQAFPVsysSSGARR X -RET Ret P07949 human PLCG1 5335 P19174 PLCG1 human Y783 447667 EGRNPGFyVEANPMP X 2821; 14461; 14008; 25678; 88717 -RET Ret P07949 human ERK1 5595 P27361 MAPK3 human T202 447542 HDHtGFLtEyVAtRW Pkinase X 9106; 4370; 4374; 9101; 4375; 4376; 4377; 3510; 5726; 88569; 13214; 13148; 70235; 9488; 89967; 8544; 14196; 14227; 14095; 14474; 75165; 98168; 33370; 54240; 15892; 45899; 55088; 9524; 69217; 48735 -RET Ret P07949 human AFAP1L2 84632 Q8N4X5 AFAP1L2 human Y54 462131 SSSsDEEyIyMNKVt X -RET Ret P07949 human Akt1 207 P31749 AKT1 human Y315 448519 tFCGtPEyLAPEVLE Pkinase X X -RET Ret P07949 human Ret 5979 P07949 RET human Y806 450700 PLLLIVEyAKyGSLR PK_Tyr_Ser-Thr X -RET Ret P07949 human Ret 5979 P07949 RET human Y900 450702 FGLSRDVyEEDsyVK PK_Tyr_Ser-Thr X -RET Ret P07949 human ERK2 5594 P28482 MAPK1 human Y187 447594 HtGFLtEyVAtRWyr Pkinase X 9106; 4370; 4374; 9101; 4375; 4376; 4377; 3510; 5726; 88569; 13214; 13148; 70235; 9488; 89967; 8544; 14196; 14227; 14095; 14474; 75165; 98168; 33370; 54240; 15892; 45899; 55088; 9524; 69217; 48735 -RET Ret P07949 human Ret 5979 P07949 RET human Y905 447627 DVyEEDsyVKRsQGR PK_Tyr_Ser-Thr X X 3221 -RET Ret P07949 human FAK 5747 Q05397 PTK2 human Y576 447889 RyMEDstyyKAsKGK PK_Tyr_Ser-Thr X X 3281 -RET Ret P07949 human ERK1 5595 P27361 MAPK3 human Y204 447543 HtGFLtEyVAtRWyr Pkinase X X 9106; 4370; 4374; 9101; 4375; 4376; 4377; 3510; 5726; 88569; 13214; 13148; 70235; 9488; 89967; 8544; 14196; 14227; 14095; 14474; 75165; 98168; 33370; 54240; 15892; 45899; 55088; 9524; 69217; 48735 -RET Ret P07949 human Ret 5979 P07949 RET human Y1062 447625 TWIENkLyGMsDPNW X X -RET Ret P07949 human P38A 1432 Q16539 MAPK14 human Y182 447971 tDDEMtGyVAtRWYR Pkinase X 9211; 9215; 4551; 9216; 4552; 4631; 4511; 4092; 9219; 24678; 8632; 6908; 41768; 51255; 14594; 14598; 62979 -Tesk1 TESK1 Q63572 rat Destrin 11034 P60981 DSTN human S3 449754 _____MAsGVQVADE X X -Tesk1 TESK1 Q63572 rat TESK1 29460 Q63572 Tesk1 rat S215 452045 EPLAVVGsPYWMAPE PK_Tyr_Ser-Thr X -Tesk1 TESK1 Q63572 rat Cofilin-1 12631 P18760 Cfl1 mouse S3 448444 _____MAsGVAVsDG X 3313; 3311 -Tesk1 TESK1 Q63572 rat Cofilin-1 1072 P23528 CFL1 human S3 448444 _____MAsGVAVsDG X X 3313; 3311 -HIPK4 HIPK4 Q8NE63 human RIMBP3 239731 Q3V0F0 Rimbp3 mouse S15 1879727000 PLGGGRAsPKKPSsP X -HIPK4 HIPK4 Q8NE63 human RIMBP3 239731 Q3V0F0 Rimbp3 mouse S21 36704995 AsPKKPSsPGPAAAV X -HIPK4 HIPK4 Q8NE63 human RIMBP3 239731 Q3V0F0 Rimbp3 mouse S263 17545556 NTGVRVHsPNDLLPT X -HIPK4 HIPK4 Q8NE63 human RIMBP3 239731 Q3V0F0 Rimbp3 mouse S347 599813228 PCEASTSsPPGLDYQ X -Prkcz PKCZ P09217 rat PKCZ 25522 P09217 Prkcz rat T560 447572 TSEPVQLtPDDEDVI Pkinase_C X -Prkcz PKCZ P09217 rat ATP1A1 24211 P06685 Atp1a1 rat S16 449086 KyEPAAVsEHGDkks X 4020 -Prkcz PKCZ P09217 rat ATP1A1 24211 P06685 Atp1a1 rat S23 449087 sEHGDkkskkAKKER X 4006 -Prkcz PKCZ P09217 rat IRS1 25467 P35570 Irs1 rat S318 451399 MVGGkPGsFRVRAss X X 5610 -Prkcz PKCZ P09217 rat Akt1 24185 P47196 Akt1 rat T34 455493 FLLKNDGtFIGYKER PH X -Prkcb PKCB iso2 P68403-2 rat RKIP 29542 P31044 Pebp1 rat S153 448755 RGkFkVEsFRKKYHL PBP X -Prkcb PKCB iso2 P68403-2 rat GABRB3 24922 P63079 Gabrb3 rat S433 450246 THLRRRssQLKIKIP Neur_chan_memb X -Prkcb PKCB iso2 P68403-2 rat GABRB3 24922 P63079 Gabrb3 rat S432 450245 KTHLRRRssQLKIKI Neur_chan_memb X -Prkcb PKCB iso2 P68403-2 rat GABRB1 25450 P15431 Gabrb1 rat S434 450244 GRIRRRAsQLKVKIP Neur_chan_memb X -CDK5 CDK5 Q02399 cow PPP1CA 5499 P62136 PPP1CA human T320 448686 NPGGRPItPPRNsAK X 2581 -CDK5 CDK5 Q02399 cow SYN1 281510 P17599 SYN1 cow S553 448377 TRPPAsPsPQRQAGP X -CDK5 CDK5 Q02399 cow PPP1R1A 5502 Q13522 PPP1R1A human S67 447758 LKSTLAMsPRQRKKM DARPP-32 X -LYN LYN P07948 human Syk 20963 P48025 Syk mouse Y317 447658 STVSFNPyEPtGGPW X X 2715 -LYN LYN P07948 human NMT1 4836 P30419 NMT1 human Y180 10336300 YTLLNENyVEDDDNM NMT X -LYN LYN P07948 human Abl 25 P00519 ABL1 human Y393 450298 RLMtGDtytAHAGAk PK_Tyr_Ser-Thr X 2865 -LYN LYN P07948 human YY1 7528 P25490 YY1 human Y8 41608701 MASGDTLyIATDGSE X -LYN LYN P07948 human AKAP8 10270 O43823 AKAP8 human Y53 40420004 TTGATySyGPASWEA X -LYN LYN P07948 human GCET2 257144 Q8N6F7 GCSAM human Y106 463673 sGNsAEEyyENVPCk HGAL X -LYN LYN P07948 human ACLY 47 P53396 ACLY human Y682 450360 sRtTDGVyEGVAIGG Ligase_CoA X X -LYN LYN P07948 human RGS16 6004 O15492 RGS16 human Y177 448653 RFLkSPAyRDLAAQA RGS X -LYN LYN P07948 human Ig-alpha 12518 P11911 Cd79a mouse Y182 473649 DyEDENLyEGLNLDD ITAM X 14948; 5173; 14732; 29742; 52821; 17749 -LYN LYN P07948 human CD163L1 338056 P30205 CD163L1 cow Y1326 470034 DALAEAVyEELDYLL X -LYN LYN P07948 human SLC4A1 6521 P02730 SLC4A1 human Y21 457533 ENLEQEEyEDPDIPE X -LYN LYN P07948 human SLC4A1 6521 P02730 SLC4A1 human Y8 451570 MEELQDDyEDMMEEN X -LYN LYN P07948 human SHP-1 5777 P29350 PTPN6 human Y564 448912 sKHkEDVyENLHTkN X 8849 -LYN LYN P07948 human FCGR2A 2212 P12318 FCGR2A human Y304 449552 tDDDKNIyLTLPPND X -LYN LYN P07948 human ACLY 47 P53396 ACLY human Y131 450359 YATREGDyVLFHHEG X X -LYN LYN P07948 human CSF2RB 1439 P32927 CSF2RB human Y882 2358800 KALKQQDyLSLPPWE X -LYN LYN P07948 human FAM82A2 55177 Q96TC7 RMDN3 human Y176 19009800 DAESEGGytTANAEs X -LYN LYN P07948 human CSF2RB 1439 P32927 CSF2RB human Y822 450124 VLQQVGDyCFLPGLG X -LYN LYN P07948 human TIF1B 10155 Q13263 TRIM28 human Y517 464439 PGsTtEDyNLIVIER X -LYN LYN P07948 human CASP8 841 Q14790 CASP8 human Y380 460647 tDsEEQPyLEMDLSs Peptidase_C14 X -LYN LYN P07948 human Syk 6850 P43405 SYK human Y323 447658 sTVsFNPyEPELAPW X 2715 -LYN LYN P07948 human CSF2RB 1439 P32927 CSF2RB human Y466 3141903 ALRFCGIyGyRLRRk X -LYN LYN P07948 human CASP8 841 Q14790 CASP8 human Y448 1032277 TILTEVNyEVSNKDD Peptidase_C14 X -LYN LYN P07948 human CD19 930 P15391 CD19 human Y500 447638 TSLGsQsyEDMRGIL X X -LYN LYN P07948 human IRF5 3663 Q13568 IRF5 human Y335 25742049 QLQGQDLyAIRLCQC IRF-3 X -LYN LYN P07948 human LY96 23643 Q9Y6Y9 LY96 human Y131 21400400 IKFSKGKyKCVVEAI E1_DerP2_DerF2 X -LYN LYN P07948 human YY1 7528 P25490 YY1 human Y383 41608702 IHtGDrPyVCPFDGC zf-C2H2 X X -LYN LYN P07948 human Btk 12229 P35991 Btk mouse Y551 447486 RYVLDDEyTsSVGSK PK_Tyr_Ser-Thr X 69360; 18805; 64137; 16803 -LYN LYN P07948 human SLC4A1 6521 P02730 SLC4A1 human Y359 455384 AKPDssFyKGLDLNG X X -LYN LYN P07948 human Abl 25 P00519 ABL1 human Y128 459259 SLEKHSWyHGPVSRN SH2 X -LYN LYN P07948 human AKAP8 10270 O43823 AKAP8 human Y154 476956 RPsySyDyEFDLGSD X -LYN LYN P07948 human BIM 12125 O54918 Bcl2l11 mouse Y161 810853200 GDEFNETyTRRVFAN Bclx_interact X -LYN LYN P07948 human p27Kip1 1027 P46527 CDKN1B human Y88 456818 kGsLPEFyyRPPRPP X -LYN LYN P07948 human FCGR2B 2213 P31994 FCGR2B human Y292 448507 GAENTITysLLMHPD X -LYN LYN P07948 human TIF1B 10155 Q13263 TRIM28 human Y449 3576406 PMEVQEGyGFGsGDD X -LYN LYN P07948 human AKAP8 10270 O43823 AKAP8 human Y539 40420000 IVkMLEkyLKGEDPF AKAP95 X -LYN LYN P07948 human PTEN 5728 P60484 PTEN human Y240 448316 RREDKFMyFEFPQPL PTEN_C2 X -LYN LYN P07948 human LAB 7462 Q9GZY6 LAT2 human Y95 455006 EDPASSRyQNFSkGs LAT2 X -LYN LYN P07948 human CBL 867 P22681 CBL human Y371 449753 TQEQyELyCEMGSTF X -LYN LYN P07948 human Abl 25 P00519 ABL1 human Y226 450303 KRNKPtVyGVsPNyD X 2868; 2861 -LYN LYN P07948 human LY96 23643 Q9Y6Y9 LY96 human Y22 21400401 FTEAQKQyWVCNSSD X -LYN LYN P07948 human Abl 25 P00519 ABL1 human Y115 450305 QGWVPsNyItPVNSL X -LYN LYN P07948 human GCET2 257144 Q8N6F7 GCSAM human Y128 463674 LGGTEtEySLLHMPS HGAL X X -LYN LYN P07948 human Syk 6850 P43405 SYK human Y348 447659 LPMDtEVyEsPyADP X -LYN LYN P07948 human PKCD 18753 P28867 Prkcd mouse Y565 447576 IRVDTPHyPRWITKE Pkinase X -LYN LYN P07948 human GCET2 257144 Q8N6F7 GCSAM human Y107 454098 GNsAEEyyENVPCkA HGAL X X -LYN LYN P07948 human IKKB 3551 O14920 IKBKB human Y188 449632 sFVGTLQyLAPELLE Pkinase X -LYN LYN P07948 human ACLY 47 P53396 ACLY human Y252 462909 EAyPEEAyIADLDAk Citrate_bind X X -LYN LYN P07948 human Abl 25 P00519 ABL1 human Y215 469589 GLITTLHyPAPKRNK X -LYN LYN P07948 human Abl 25 P00519 ABL1 human Y70 462900 PNLFVALyDFVAsGD SH3_1 X 3098 -LYN LYN P07948 human PEAK1 79834 Q9H792 PEAK1 human Y635 449709 IVINPNAyDNLAIyK X -LYN LYN P07948 human CDK4 1019 P11802 CDK4 human Y17 455500 AEIGVGAyGTVYkAR Pkinase X -LYN LYN P07948 human AKAP8 10270 O43823 AKAP8 human Y146 40420002 CLPEHNPyRPsySyD X -LYN LYN P07948 human AKAP8 10270 O43823 AKAP8 human Y170 15417596 NGsFGGQySECRDPA X -LYN LYN P07948 human Syk 6850 P43405 SYK human Y526 447662 LRADENyykAQtHGK PK_Tyr_Ser-Thr X 2711; 2710; 12967; 5514; 4349; 6485; 12081; 46994; 16859 -LYN LYN P07948 human SOCS1 8651 O15524 SOCS1 human Y80 1868450203 LLDACGFyWGPLSVH SH2 X -LYN LYN P07948 human LYN 4067 P07948 LYN human Y508 447624 ytAtEGQyQQQP___ X 2731 -LYN LYN P07948 human COX-2 5743 P35354 PTGS2 human Y120 34434400 PPTYNADyGYKSWEA X -LYN LYN P07948 human GLO1 2739 Q04760 GLO1 human Y136 463450 GIAVPDVysACkRFE Glyoxalase X -LYN LYN P07948 human LAB 7462 Q9GZY6 LAT2 human Y119 454710 DPIAMEyyNWGRFSk LAT2 X -LYN LYN P07948 human SLC4A1 6521 P02730 SLC4A1 human Y904 455304 EEEGRDEyDEVAMPV X X -LYN LYN P07948 human FCGR2C 9103 P31995 FCGR2C human Y310 449501 tDDDKNIyLTLPPND X -LYN LYN P07948 human Bcr 613 P11274 BCR human Y177 447792 ADAEKPFyVNVEFHH X 3901 -LYN LYN P07948 human ACLY 47 P53396 ACLY human Y659 55373280 yRPGsVAyVSRsGGM X X -LYN LYN P07948 human DBNL 13169 Q62418 Dbnl mouse Y340 450090 QTEEEPTyEVPPEQD X -LYN LYN P07948 human Btk 695 Q06187 BTK human Y223 447485 LKKVVALyDyMPMNA SH3_1 X 5082; 87141; 87457 -LYN LYN P07948 human AKAP8 10270 O43823 AKAP8 human Y51 40420005 SVTTGATySyGPASW X -LYN LYN P07948 human PKCD 18753 P28867 Prkcd mouse Y311 447573 TTEsVGIyQGFEKKP X 2055 -LYN LYN P07948 human IFITM3 66141 Q9CQW9 Ifitm3 mouse Y20 463584 SGGQPPNyERIkEEy X -LYN LYN P07948 human CD19 930 P15391 CD19 human Y531 447639 HEEDADsyENMDNPD X X 3571 -LYN LYN P07948 human Abl 25 P00519 ABL1 human Y139 456712 VSRNAAEyLLsSGIN SH2 X -LYN LYN P07948 human LAB 7462 Q9GZY6 LAT2 human Y110 454708 RHGsEEAyIDPIAME LAT2 X -LYN LYN P07948 human IRF5 3663 Q13568 IRF5 human Y313 57775901 PSDkQRFyTNQLLDV IRF-3 X -LYN LYN P07948 human LYN 4067 P07948 LYN human Y397 448695 RVIEDNEytAREGAk PK_Tyr_Ser-Thr X 2101; 6943; 59548; 70926; 78740; 94361; 17320 -LYN LYN P07948 human PKCD 18753 P28867 Prkcd mouse Y155 447575 IKQAKIHyIKNHEFI X -LYN LYN P07948 human AKAP8 10270 O43823 AKAP8 human Y152 7366805 PyRPsySyDyEFDLG X -LYN LYN P07948 human AKAP8 10270 O43823 AKAP8 human Y150 15407467 HNPyRPsySyDyEFD X -LYN LYN P07948 human Ig-beta 15985 P15530 Cd79b mouse Y195 459286 GMEEDHTyEGLNIDQ ITAM X -LYN LYN P07948 human GluR2 14800 P23819 Gria2 mouse Y876 452173 ykEGyNVyGIEsVKI X 4027; 3921 -LYN LYN P07948 human Syk 20963 P48025 Syk mouse Y519 447661 ALRADENyyKAQTHG PK_Tyr_Ser-Thr X 2711; 2710; 12967; 5514; 4349; 6485; 12081; 46994; 16859 -LYN LYN P07948 human AFAP1L1 106877 Q8BZI0 Afap1l1 mouse Y127 41691500 KPPPEDYyEEALPLG X -LYN LYN P07948 human SHP-1 5777 P29350 PTPN6 human Y536 448506 QkGQEsEyGNItyPP X X -LYN LYN P07948 human SLAM 6504 Q13291 SLAMF1 human Y327 447634 ETNSITVyASVTLPE X X -LYN LYN P07948 human GCET2 257144 Q8N6F7 GCSAM human Y86 449473 tysEELCytLINHRV HGAL X -LYN LYN P07948 human RGS16 6004 O15492 RGS16 human Y168 448652 TLMEKDSyPRFLkSP RGS X -LYN LYN P07948 human leupaxin 107321 Q99N69 Lpxn mouse Y72 449706 NIQEPNVysEVQEPK X -LYN LYN P07948 human SHP-1 15170 P29351 Ptpn6 mouse Y536 448506 QKGQEsEyGNItyPP X -LYN LYN P07948 human LYN 17096 P25911 Lyn mouse Y397 448695 RVIEDNEytAREGAK PK_Tyr_Ser-Thr X 2101; 6943; 59548; 70926; 78740; 94361; 17320 -LYN LYN P07948 human Abl 25 P00519 ABL1 human Y172 460505 LRyEGRVyHyRINTA SH2 X -LYN LYN P07948 human AKAP8 10270 O43823 AKAP8 human Y80 40420001 PAMHMASyGPEPCTD X -LYN LYN P07948 human LAB 7462 Q9GZY6 LAT2 human Y136 450963 EDDDANsyENVLICK LAT2 X -LYN LYN P07948 human PKCD 18753 P28867 Prkcd mouse Y52 447574 VQkKPTMyPEWKTTF X -LYN LYN P07948 human Syk 20963 P48025 Syk mouse Y520 447662 LRADENyyKAQTHGK PK_Tyr_Ser-Thr X 2711; 2710; 12967; 5514; 4349; 6485; 12081; 46994; 16859 -LYN LYN P07948 human LAB 7462 Q9GZY6 LAT2 human Y118 454709 IDPIAMEyyNWGRFS LAT2 X -LYN LYN P07948 human Syk 6850 P43405 SYK human Y352 447660 tEVyEsPyADPEEIR X 2701; 2717; 14791; 73382; 82975; 31754 -LYN LYN P07948 human BIM 12125 O54918 Bcl2l11 mouse Y92 56650528 LsRSSsGyFSFDTDR X X -LYN LYN P07948 human ACLY 47 P53396 ACLY human Y384 462910 VRrGGPNyQEGLrVM Citrate_bind X X -LYN LYN P07948 human ACLY 47 P53396 ACLY human Y227 1868989000 KVDATADyICkVkWG X X -LYN LYN P07948 human HS1 3059 P14317 HCLS1 human Y222 452057 MEAPttAykkTTPIE X -LYN LYN P07948 human Btk 695 Q06187 BTK human Y551 447486 RYVLDDEytsSVGSk PK_Tyr_Ser-Thr X 69360; 18805; 64137; 16803 -LYN LYN P07948 human DBNL 13169 Q62418 Dbnl mouse Y350 450091 PPEQDTLyEEPPLVQ X -LYN LYN P07948 human Abl 25 P00519 ABL1 human Y185 450304 TAsDGKLyVsSESRF SH2 X 3009 -LYN LYN P07948 human GCET2 257144 Q8N6F7 GCSAM human Y80 449472 QDNVDQtysEELCyt HGAL X -LYN LYN P07948 human Syk 6850 P43405 SYK human Y525 447661 ALRADENyykAQtHG PK_Tyr_Ser-Thr X 2711; 2710; 12967; 5514; 4349; 6485; 12081; 46994; 16859 -LYN LYN P07948 human IKKB 3551 O14920 IKBKB human Y199 449633 ELLEQQKyTVTVDYW Pkinase X -LYN LYN P07948 human CSF2RB 1439 P32927 CSF2RB human Y468 3141904 RFCGIyGyRLRRkWE X -LYN LYN P07948 human Lasp-1 3927 Q14847 LASP1 human Y171 451675 IPtsAPVyQQPQQQP X -LYN LYN P07948 human YY1 7528 P25490 YY1 human Y254 464367 sPPDySEyMTGkKLP X -LYN LYN P07948 human WASP 7454 P42768 WAS human Y291 447985 AEtsKLIyDFIEDQG PBD X -LYN LYN P07948 human Syk 20963 P48025 Syk mouse Y346 447660 TEVyESPyADPEEIR X 2701; 2717; 14791; 73382; 82975; 31754 -LYN LYN P07948 human SLCO1B1 10599 Q9Y6L6 SLCO1B1 human Y645 13831749 VLyIILIyAMKKKYQ TM X -LYN LYN P07948 human MCM7 4176 P33993 MCM7 human Y600 463418 WASkDAtyTSARtLL MCM_lid X X -LYN LYN P07948 human DAPP1 27071 Q9UN19 DAPP1 human Y139 448325 kVEEPsIyEsVRVHT X 13703 -LYN LYN P07948 human AFAP1L1 106877 Q8BZI0 Afap1l1 mouse Y557 462143 QWPEPRIyDEVPYEK X -LYN LYN P07948 human TIF1B 10155 Q13263 TRIM28 human Y458 454817 FGsGDDPyssAEPHV X -LYN LYN P07948 human AKAP8 10270 O43823 AKAP8 human Y311 3582467 KRkQFQLyEEPDTkL X -LYN LYN P07948 human AKAP8 10270 O43823 AKAP8 human Y436 40420003 TVEFLQEyIVNRNKK AKAP95 X -LYN LYN P07948 human NIPP-1 5511 Q12972 PPP1R8 human Y335 3101800 NEPKKKKyAKEAWPG X -LYN LYN P07948 human IKKG 8517 Q9Y6K9 IKBKG human Y374 473650 PLPPAPAyLssPLAL X -RPS6KA3 RSK2 P51812 human NFAT3 4776 Q14934 NFATC4 human S289 4777119 PALsRRGsLGEEGsE X X -RPS6KA3 RSK2 P51812 human KIBRA 23286 Q8IX03 WWC1 human S947 453630 CRLNRsDsDSSTLSK X X -RPS6KA3 RSK2 P51812 human NFAT3 4776 Q14934 NFATC4 human S281 13419502 SGTPSSAsPALsRRG X X -RPS6KA3 RSK2 P51812 human TH iso4 7054 P07101-4 TH human S44 448545 RFIGRRQsLIEDARK TOH_N X 2791 -RPS6KA3 RSK2 P51812 human RIOK2 55781 Q9BVS4 RIOK2 human S483 7446950 QYRTRtLsItssGsA X -RPS6KA3 RSK2 P51812 human Nur77 15370 P12813 Nr4a1 mouse S354 447942 GRRGRLPsKPKQPPD X 5095 -RPS6KA3 RSK2 P51812 human PKR 5610 P19525 EIF2AK2 human T451 448089 kRtRSKGtLRyMsPE Pkinase X -RPS6KA3 RSK2 P51812 human MASTL 67121 Q8C0P0 Mastl mouse T297 1269647500 QCRKRLGtSSTSSQS X -RPS6KA3 RSK2 P51812 human YB-1 4904 P67809 YBX1 human S102 455636 NPRKyLrsVGDGEtV CSD X X 2900 -RPS6KA3 RSK2 P51812 human TINF2 26277 Q9BSI4 TINF2 human S295 3245684 FPFRNLGsPtQVISk X X -RPS6KA3 RSK2 P51812 human H3 8350 P68431 H3C1 human S10 455676 tkQtArkstGGkAPr Histone X 9701; 9711; 9606; 3465; 3642; 3377; 3475; 3458; 5764; 47398; 8481; 8552; 53348; 29237; 66065; 43185; 64522; 52725 -RPS6KA3 RSK2 P51812 human TIF1A 54700 Q9NYV6 RRN3 human S649 448839 PVLYMQPsPL_____ X -RPS6KA3 RSK2 P51812 human S6 20104 P62754 Rps6 mouse S235 448092 IAKRRRLssLRAsts X 5006; 4856; 4857; 4858; 4851; 4803; 2211; 3945; 3985; 5316; 4854; 8520; 48319; 40643; 9865; 38573; 14733; 27036; 34411; 62016; 62788; 81736; 97935; 99457; 15448 -RPS6KA3 RSK2 P51812 human L-plastin 3936 P13796 LCP1 human S5 450852 ___MARGsVsDEEMM X -RPS6KA3 RSK2 P51812 human MRLC3 10627 P19105 MYL12A human S19 7382102 KRPQRAtsNVFAMFD X X -RPS6KA3 RSK2 P51812 human TBX21 30009 Q9UL17 TBX21 human S503 56676120 DSKRRRVsPYPsSGD X X -RPS6KA3 RSK2 P51812 human TBX21 30009 Q9UL17 TBX21 human S507 322212300 RRVsPYPsSGDSsSP X X -RPS6KA3 RSK2 P51812 human ASK1 4217 Q99683 MAP3K5 human T1109 27928508 DRKIIATtLSKLkLE HisK-N-like X X -RPS6KA3 RSK2 P51812 human DAPK1 1612 P53355 DAPK1 human S289 457379 QALSRKAsAVNMEkF X -RPS6KA3 RSK2 P51812 human CREB iso1 81646 P15337-1 Creb1 rat S133 448228 EILsRRPsYRkILND pKID X 9187; 9196; 9198; 4095; 14228; 14001; 39561; 80120; 44864; 54960; 95995 -RPS6KA3 RSK2 P51812 human STAT3 6774 P40763 STAT3 human S727 448191 NtIDLPMsPrTLDSL X 9134; 9136; 34911; 94994; 49081; 58978; 87544; 71958; 50804 -RPS6KA3 RSK2 P51812 human STMN1 3925 P16949 STMN1 human S16 448554 kELEKrAsGQAFELI Stathmin X X 3353 -RPS6KA3 RSK2 P51812 human EphA2 1969 P29317 EPHA2 human S897 1244153 RVsIRLPstsGsEGV X X 16662; 6347 -RPS6KA3 RSK2 P51812 human BAD 572 Q92934 BAD human S99 447862 PFrGrsRsAPPNLWA Bcl-2_BAD X 9295; 5286; 4366 -RPS6KA3 RSK2 P51812 human NFAT3 4776 Q14934 NFATC4 human S344 11163859 QAVALPRsEEPASCN X X -RPS6KA3 RSK2 P51812 human KIBRA 23286 Q8IX03 WWC1 human T929 3205626 stIIRsKtFsPGPQS X X -RPS6KA3 RSK2 P51812 human IkB-alpha 4792 P25963 NFKBIA human S32 448203 LLDDRHDsGLDsMkD X X 5210; 2859; 9246; 5209 -RPS6KA3 RSK2 P51812 human GSK3A 2931 P49840 GSK3A human S21 448584 sGrARtssFAEPGGG X 9337; 9316; 9331; 5090; 9327; 8452; 8566 -RPS6KA3 RSK2 P51812 human PPP1R3A 5506 Q16821 PPP1R3A human S65 449321 SSGTRRVsFADSFGF X -RPS6KA3 RSK2 P51812 human NFAT3 4776 Q14934 NFATC4 human S676 455348 SNGRRKRsPTQSFRF RHD_dimer X X -RPS6KA3 RSK2 P51812 human 5-HT(2A) 29595 P14842 Htr2a rat S314 6057801 AGRRTMQsISNEQKA 7tm_1 X X -RPS6KA3 RSK2 P51812 human NFAT3 4776 Q14934 NFATC4 human S285 13419501 SSAsPALsRRGsLGE X X -RPS6KA3 RSK2 P51812 human SPRED2 200734 Q7Z698 SPRED2 human S168 12738131 QPTRTIssPTSCEHR X X -RPS6KA3 RSK2 P51812 human ASK1 4217 Q99683 MAP3K5 human S83 447735 ATRGRGssVGGGSrR X X 3761 -RPS6KA3 RSK2 P51812 human BAD 572 Q92934 BAD human S75 447860 EIRsRHssyPAGtED Bcl-2_BAD X X 9291; 5284; 9296; 5193; 11865; 94223 -RPS6KA3 RSK2 P51812 human CASP8 841 Q14790 CASP8 human T263 21258500 SIRDRNGtHLDAGAL Peptidase_C14 X X -RPS6KA3 RSK2 P51812 human PFKFB2 287019 P26285 PFKFB2 cow S484 452046 IRRPRNYsVGSRPLQ X -RPS6KA3 RSK2 P51812 human CREB 1385 P16220 CREB1 human S119 448228 EILsRRPsyRkILND pKID X 9187; 9196; 9198; 4095; 14228; 14001; 39561; 80120; 44864; 54960; 95995 -RPS6KA3 RSK2 P51812 human GSK3B 2932 P49841 GSK3B human S9 449111 SGRPRttsFAEsCkP X X 9336; 9331; 9327; 9323; 9322; 9325; 5558; 8566; 79774; 8466; 25462; 14026; 14332; 14310; 14630 -RPS6KA3 RSK2 P51812 human RANBP3 8498 Q9H6Z4 RANBP3 human S126 460735 VKRERtssLtQFPPs X 9380 -RPS6KA3 RSK2 P51812 human GATA4 54254 P46152 Gata4 rat S261 450013 IKPQRRLsASRRVGL X -RPS6KA3 RSK2 P51812 human ER-alpha 2099 P03372 ESR1 human S167 448102 GGRERLAsTNDkGSM Oest_recep X 64508; 42101 -RPS6KA3 RSK2 P51812 human H2AX 3014 P16104 H2AX human S16 33703202 kARAkAksRSsrAGL Histone X X -RPS6KA3 RSK2 P51812 human S6 6194 P62753 RPS6 human S236 448093 AKRRRLssLRAstsK X 5006; 4856; 4857; 4858; 4851; 4803; 2211; 3945; 3985; 5316; 4854; 8520; 48319; 40643; 9865; 38573; 14733; 27036; 34411; 62016; 62788; 81736; 97935; 99457; 15448 -RPS6KA3 RSK2 P51812 human RSK2 6197 P51812 RPS6KA3 human S386 448065 HQLFRGFsFVAItsD Pkinase_C X 9341; 9335; 13575; 11989; 12032; 75266; 93317; 13397; 13588 -RPS6KA3 RSK2 P51812 human VGLL1 51442 Q99990 VGLL1 human S84 1870773106 PNQWRYSsPWTKPQP X -RPS6KA3 RSK2 P51812 human NFkB-p65 5970 Q04206 RELA human S276 447798 sMQLRRPsDRELsEP RHD_dimer X -RPS6KA3 RSK2 P51812 human TINF2 26277 Q9BSI4 TINF2 human S330 7322600 ASTGKSKsPCQTLGG X X -RPS6KA3 RSK2 P51812 human TH iso2 7054 P07101-2 TH human S67 448545 RFIGRRQsLIEDARK TOH_N X 2791 -RPS6KA3 RSK2 P51812 human ASK1 4217 Q99683 MAP3K5 human T1326 27928509 VNGADEDtISRFLAE X X -RPS6KA3 RSK2 P51812 human S6 29304 P62755 Rps6 rat S236 448093 AKRRRLssLRAstsK X 5006; 4856; 4857; 4858; 4851; 4803; 2211; 3945; 3985; 5316; 4854; 8520; 48319; 40643; 9865; 38573; 14733; 27036; 34411; 62016; 62788; 81736; 97935; 99457; 15448 -RPS6KA3 RSK2 P51812 human TH 7054 P07101 TH human S71 448545 RFIGRRQsLIEDARK TOH_N X 2791 -RPS6KA3 RSK2 P51812 human PPP1R3A 5506 Q16821 PPP1R3A human S46 449320 PQPSRRGsDssEDIY X -RPS6KA3 RSK2 P51812 human ATF-4 468 P18848 ATF4 human S245 451446 TrGSPNRsLPsPGVL X X -RPS6KA3 RSK2 P51812 human FOXN2 3344 P32314 FOXN2 human S369 799824600 LGDsGYAsQPCAKIS X -RPS6KA3 RSK2 P51812 human FOXN2 3344 P32314 FOXN2 human S365 799824601 EDDPLGDsGYAsQPC X -RPS6KA3 RSK2 P51812 human MYBPC3 295929 P56741 Mybpc3 rat S288 471080 AGTGRRtsDSHEDAG X -RPS6KA3 RSK2 P51812 human SPRED2 200734 Q7Z698 SPRED2 human S167 23147996 EQPTRTIssPTSCEH X X -RPS6KA3 RSK2 P51812 human H2B 3018 P33778 H2BC3 human S32 447801 DGKkRKRsRkEsysI Histone X X -RPS6KA3 RSK2 P51812 human PFKFB2 287019 P26285 PFKFB2 cow S467 448460 PVRMRRNsFTPLSSS X -RPS6KA3 RSK2 P51812 human FGFR1 2260 P11362 FGFR1 human S789 4703530 DTRSSTCsSGEDSVF X X -RPS6KA3 RSK2 P51812 human S6 6194 P62753 RPS6 human S235 448092 IAKRRRLssLRAsts X 5006; 4856; 4857; 4858; 4851; 4803; 2211; 3945; 3985; 5316; 4854; 8520; 48319; 40643; 9865; 38573; 14733; 27036; 34411; 62016; 62788; 81736; 97935; 99457; 15448 -RPS6KA3 RSK2 P51812 human NHE3 6550 P48764 SLC9A3 human S663 457469 TMRKRLEsFKSTKLG X -RPS6KA3 RSK2 P51812 human TH iso3 7054 P07101-3 TH human S40 448545 RFIGRRQsLIEDARK TOH_N X 2791 -RPS6KA3 RSK2 P51812 human capicua 23152 Q96RK0 CIC human S173 3209781 PGKRRtQsLsALPKE X -RPS6KA3 RSK2 P51812 human C/EBP-beta 24253 P21272 Cebpb rat S273 13373502 QKKVEQLsRELSTLR bZIP_2 X -RPS6KA3 RSK2 P51812 human eIF2-alpha 1965 P05198 EIF2S1 human S52 447635 MILLsELsRRRIRsI S1 X 3597; 9721; 3398; 5199; 53085; 95797 -RPS6KA3 RSK2 P51812 human S6 20104 P62754 Rps6 mouse S236 448093 AKRRRLssLRAstsK X 5006; 4856; 4857; 4858; 4851; 4803; 2211; 3945; 3985; 5316; 4854; 8520; 48319; 40643; 9865; 38573; 14733; 27036; 34411; 62016; 62788; 81736; 97935; 99457; 15448 -RPS6KA3 RSK2 P51812 human KCNK3 3777 O14649 KCNK3 human S393 2840504 GLMKRRssV______ X -TTBK2 TTBK2 Q6IQ55 human SV2A 9900 Q7L0J3 SV2A human S47 4779746 EysRRsYsRFEEEDD X -TTBK2 TTBK2 Q6IQ55 human SV2A 9900 Q7L0J3 SV2A human T84 4779764 GGAssDAtEGHDEDD X -TTBK2 TTBK2 Q6IQ55 human SV2A 9900 Q7L0J3 SV2A human S45 40245506 QDEysRRsYsRFEEE X -TTBK2 TTBK2 Q6IQ55 human CCDC41 51134 Q9Y592 CEP83 human S698 14571164 KQLEELGsSGE____ X X -TTBK2 TTBK2 Q6IQ55 human SV2A 9900 Q7L0J3 SV2A human S80 4779752 DEEEGGAssDAtEGH X -TTBK2 TTBK2 Q6IQ55 human SV2A 9900 Q7L0J3 SV2A human S81 4779758 EEEGGAssDAtEGHD X -TTBK2 TTBK2 Q6IQ55 human SV2A 9900 Q7L0J3 SV2A human S42 15415491 DRVQDEysRRsYsRF X -TTBK2 TTBK2 Q6IQ55 human KIF2A 3796 O00139 KIF2A human S135 4705535 SSAQQNGsVsDIsPV X X -Csnk1g2 CK1G2 Q8BVP5 mouse CK1G2 103236 Q8BVP5 Csnk1g2 mouse T215 1871246001 EHKsLTGtARYMSIN Pkinase X -Csnk1g2 CK1G2 Q8BVP5 mouse CK1G2 103236 Q8BVP5 Csnk1g2 mouse S211 1871246000 IPYREHKsLTGtARY Pkinase X -BTK Btk Q06187 human GTF2I iso2 2969 P78347-2 GTF2I human Y248 448250 EESEDPDyyQyNIQG X X -BTK Btk Q06187 human PLCG2 5336 P16885 PLCG2 human Y753 447940 ERDINSLyDVsRMyV X X -BTK Btk Q06187 human TIRAP 114609 P58753 TIRAP human Y106 463809 AAQDLVSyLEGSTAS TIR_2 X -BTK Btk Q06187 human Btk 12229 P35991 Btk mouse Y223 447485 LKKVVALyDyMPMNA SH3_1 X 5082; 87141; 87457 -BTK Btk Q06187 human Etk 660 P51813 BMX human Y216 449835 SSTSLAQyDSNSKKI X -BTK Btk Q06187 human Ikaros 10320 Q13422 IKZF1 human S214 28735108 GRSYKQRssLEEHkE zf-C2H2 X -BTK Btk Q06187 human CREB iso1 81646 P15337-1 Creb1 rat S133 448228 EILsRRPsYRkILND pKID X 9187; 9196; 9198; 4095; 14228; 14001; 39561; 80120; 44864; 54960; 95995 -BTK Btk Q06187 human PLCG2 29337 P24135 Plcg2 rat Y753 447940 ERDINSLyDVSRMyV X X -BTK Btk Q06187 human Ikaros 10320 Q13422 IKZF1 human S215 28735107 RSYKQRssLEEHkER zf-C2H2 X -BTK Btk Q06187 human TIRAP 114609 P58753 TIRAP human Y86 463808 SSRWSKDyDVCVCHS X -BTK Btk Q06187 human TEC 7006 P42680 TEC human Y206 449836 RLERGQEyLILEKND SH3_1 X -BTK Btk Q06187 human GTF2I iso2 2969 P78347-2 GTF2I human Y357 448251 QSHVEDLyVEGLPEG GTF2I X X -BTK Btk Q06187 human PLCG2 29337 P24135 Plcg2 rat Y1197 447938 LESEEELySSCRQLR X X -BTK Btk Q06187 human IkB-alpha 4792 P25963 NFKBIA human Y305 448799 FtEDELPyDDCVFGG X X -BTK Btk Q06187 human PLCG2 29337 P24135 Plcg2 rat Y1217 447939 LNNQLFLyDTHQNLR X X 3871 -BTK Btk Q06187 human Btk 695 Q06187 BTK human Y223 447485 LKKVVALyDyMPMNA SH3_1 X X 5082; 87141; 87457 -BTK Btk Q06187 human ITK 3702 Q08881 ITK human Y180 449834 ETVVIALyDyQtNDP SH3_1 X -BTK Btk Q06187 human TIRAP 114609 P58753 TIRAP human Y187 463810 SGLSRAAyPPELRFM TIR_2 X -BTK Btk Q06187 human PLCG2 5336 P16885 PLCG2 human Y759 447941 LyDVsRMyVDPsEIN X X 3874; 50535 -BTK Btk Q06187 human G3BP-1 10146 Q13283 G3BP1 human Y40 1877717200 FYGkNSSyVHGGLDs NTF2 X -BTK Btk Q06187 human STAT5A 20850 P42230 Stat5a mouse Y694 447767 LAKAVDGyVkPQIKQ X 9365; 9356; 9359; 9351; 4322; 9314; 3939; 40284; 5387; 14603; 66740; 51879; 72712 -BTK Btk Q06187 human IkB-alpha 4792 P25963 NFKBIA human Y289 1867984206 EsEDEEsyDtEsEFT X -BTK Btk Q06187 human DDX41 51428 Q9UJV9 DDX41 human Y414 40253300 DVIQEVEyVkEEAKM X X -BTK Btk Q06187 human GTF2I iso2 2969 P78347-2 GTF2I human Y462 448252 EAHPNDLyVEGLPEN GTF2I X X -BTK Btk Q06187 human Btk 695 Q06187 BTK human Y551 447486 RYVLDDEytsSVGSk PK_Tyr_Ser-Thr X X 69360; 18805; 64137; 16803 -BTK Btk Q06187 human p53 7157 P04637 TP53 human S15 447490 PsVEPPLsQEtFsDL P53_TAD X X 4030; 9235; 9284; 9286; 8695; 8514; 82530; 56979 -BTK Btk Q06187 human PLCG2 29337 P24135 Plcg2 rat Y759 447941 LyDVSRMyVDPSEIN X X 3874; 50535 -BTK Btk Q06187 human PLCG2 5336 P16885 PLCG2 human Y1217 447939 LNNQLFLyDtHQNLR X 3871 -Camk2g CAMK2G Q923T9 mouse STAT1 6772 P42224 STAT1 human S727 447753 TDNLLPMsPEEFDEV STAT1_TAZ2bind X 9177; 8826; 62390 -Camk2g CAMK2G Q923T9 mouse ANO1 101772 Q8BHY3 Ano1 mouse S673 288031701 YLKLRRQsPSDREEY Anoctamin X -IRAK4 IRAK4 Q9NWZ3 human PELI1 57162 Q96FA3 PELI1 human T80 7388010 DQHsIsYtLsRAQtV Pellino X -IRAK4 IRAK4 Q9NWZ3 human p47phox 653361 P14598 NCF1 human S348 451728 PGPQsPGsPLEEERQ X -IRAK4 IRAK4 Q9NWZ3 human IRAK4 51135 Q9NWZ3 IRAK4 human T345 2045325 kFAQtVMtsRIVGTt PK_Tyr_Ser-Thr X X 12914; 11927; 80738; 87995 -IRAK4 IRAK4 Q9NWZ3 human PELI1 57162 Q96FA3 PELI1 human T288 7388016 QCPVGFNtLAFPsMk Pellino X -IRAK4 IRAK4 Q9NWZ3 human PELI1 57162 Q96FA3 PELI1 human T127 7452903 GSQSNsDtQSVQSTI Pellino X -IRAK4 IRAK4 Q9NWZ3 human p47phox 653361 P14598 NCF1 human T356 474563 PLEEERQtQRsKPQP X X -IRAK4 IRAK4 Q9NWZ3 human p47phox 653361 P14598 NCF1 human S320 451726 QRsRKRLsQDAYRRN NECFESHC X X -IRAK4 IRAK4 Q9NWZ3 human IRAK1 3654 P51617 IRAK1 human S376 449756 GSsPsQssMVARtQT Pkinase X -IRAK4 IRAK4 Q9NWZ3 human IRAK4 51135 Q9NWZ3 IRAK4 human T209 2859006 KGYVNNttVAVKKLA PK_Tyr_Ser-Thr X -IRAK4 IRAK4 Q9NWZ3 human IRAK4 51135 Q9NWZ3 IRAK4 human S8 2859004 MNkPItPsTYVRCLN X -IRAK4 IRAK4 Q9NWZ3 human IRAK4 51135 Q9NWZ3 IRAK4 human S346 2045338 FAQtVMtsRIVGTtA PK_Tyr_Ser-Thr X X 12914; 11927; 80738; 87995 -IRAK4 IRAK4 Q9NWZ3 human p47phox 653361 P14598 NCF1 human S370 451730 PAVPPRPsADLILNR p47_phox_C X -IRAK4 IRAK4 Q9NWZ3 human PELI1 57162 Q96FA3 PELI1 human S82 7388012 HsIsYtLsRAQtVVV Pellino X -IRAK4 IRAK4 Q9NWZ3 human IRAK4 51135 Q9NWZ3 IRAK4 human T342 2045344 AsEkFAQtVMtsRIV PK_Tyr_Ser-Thr X X -IRAK4 IRAK4 Q9NWZ3 human IRAK4 51135 Q9NWZ3 IRAK4 human T352 31823504 tsRIVGTtAYMAPEA PK_Tyr_Ser-Thr X -IRAK4 IRAK4 Q9NWZ3 human PELI1 57162 Q96FA3 PELI1 human S70 7452902 PQAAKAIsNKDQHsI Pellino X -IRAK4 IRAK4 Q9NWZ3 human p47phox 653361 P14598 NCF1 human S288 474561 QKsGQDVsQAQRQIK NECFESHC X X -IRAK4 IRAK4 Q9NWZ3 human p47phox 653361 P14598 NCF1 human T153 474560 KSTATDItGPIILQT X -IRAK4 IRAK4 Q9NWZ3 human IRAK1 3654 P51617 IRAK1 human T387 447721 RtQTVRGtLAYLPEE Pkinase X -IRAK4 IRAK4 Q9NWZ3 human IRAK4 51135 Q9NWZ3 IRAK4 human T208 2859008 YKGYVNNttVAVKKL PK_Tyr_Ser-Thr X -IRAK4 IRAK4 Q9NWZ3 human PELI1 57162 Q96FA3 PELI1 human S78 7388013 NKDQHsIsYtLsRAQ Pellino X -IRAK4 IRAK4 Q9NWZ3 human PELI1 57162 Q96FA3 PELI1 human T86 7388011 YtLsRAQtVVVEYTH Pellino X -IRAK4 IRAK4 Q9NWZ3 human p47phox 653361 P14598 NCF1 human S345 451727 QARPGPQsPGsPLEE X X -IRAK4 IRAK4 Q9NWZ3 human p47phox 653361 P14598 NCF1 human T133 474558 KLPTDNQtKKPEtyL X X -IRAK4 IRAK4 Q9NWZ3 human p47phox 653361 P14598 NCF1 human T138 474559 NQtKKPEtyLMPKDG X -IRAK4 IRAK4 Q9NWZ3 human IRAK4 51135 Q9NWZ3 IRAK4 human T6 2859005 __MNkPItPsTYVRC X -IRAK4 IRAK4 Q9NWZ3 human IRAK4 51135 Q9NWZ3 IRAK4 human S151 2859001 SYMPPDsssPENKsL X -IRAK4 IRAK4 Q9NWZ3 human PELI1 57162 Q96FA3 PELI1 human S293 7388014 FNtLAFPsMkRkDVV Pellino X -IRAK4 IRAK4 Q9NWZ3 human IRAK4 51135 Q9NWZ3 IRAK4 human S152 2859003 YMPPDsssPENKsLE X -IRAK4 IRAK4 Q9NWZ3 human IRAK4 51135 Q9NWZ3 IRAK4 human S114 2859007 KTANTLPskEAITVQ X -IRAK4 IRAK4 Q9NWZ3 human PELI1 57162 Q96FA3 PELI1 human S76 7388015 IsNKDQHsIsYtLsR Pellino X -IRAK4 IRAK4 Q9NWZ3 human IRAK4 51135 Q9NWZ3 IRAK4 human S150 2859002 QSYMPPDsssPENKs X -IRAK4 IRAK4 Q9NWZ3 human p47phox 653361 P14598 NCF1 human S359 451729 EERQtQRsKPQPAVP p47_phox_C X -Mapk8 JNK1 Q91Y86 mouse JunB 3726 P17275 JUNB human T102 1814001 SNGVITTtPtPPGQy Jun X 8053 -Mapk8 JNK1 Q91Y86 mouse Jun 16476 P05627 Jun mouse S73 447943 VGLLKLAsPELERLI Jun X X 9164; 3270; 8752; 12714; 77955 -Mapk8 JNK1 Q91Y86 mouse EEF1A2 1917 Q05639 EEF1A2 human S358 27930803 GQISAGYsPVIDCHT GTP_EFTU_D3 X -Mapk8 JNK1 Q91Y86 mouse NET1 307098 A0A8I6AVA8 Net1 rat S106 3204291 TSLANLIsPVRNGAV X -Mapk8 JNK1 Q91Y86 mouse ATF-2 1386 P15336 ATF2 human T71 448225 IVADQtPtPtRFLkN X 9225; 9221; 5112; 94125; 13850; 40749; 15411; 24329; 61584; 27934; 92109; 20534; 35858 -Mapk8 JNK1 Q91Y86 mouse SIRT1 93759 Q923E4 Sirt1 mouse S46 452899 DGPGLGRsPGEPsAA X -Mapk8 JNK1 Q91Y86 mouse NRL 18185 P54846 Nrl mouse S50 478419 PYSSVPPsPTFSEPG X -Mapk8 JNK1 Q91Y86 mouse NFAT3 4776 Q14934 NFATC4 human S217 953803 GLGsPLPsPRAsPRP X -Mapk8 JNK1 Q91Y86 mouse SARM1 287545 D3ZUM2 Sarm1 rat S548 4739912 AAREMLHsPLPCTGG X -Mapk8 JNK1 Q91Y86 mouse DICER1 192119 Q8R418 Dicer1 mouse S1456 31084113 IDSMLMGsGAFVRkI Ribonuclease_3 X -Mapk8 JNK1 Q91Y86 mouse MLP 17357 P28667 Marcksl1 mouse T183 454301 PQAAEPstPsGPEsG MARCKS X -Mapk8 JNK1 Q91Y86 mouse BMAL1 406 O00327 BMAL1 human S592 25352000 DNDQGSSsPSNDEAA X -Mapk8 JNK1 Q91Y86 mouse RXRA 20181 P28700 Rxra mouse S265 450891 NMGLNPSsPNDPVTN Hormone_recep X -Mapk8 JNK1 Q91Y86 mouse BMAL1 406 O00327 BMAL1 human S520 25352001 SPSSCGSsPLNITSt X -Mapk8 JNK1 Q91Y86 mouse LISCH iso2 54135 Q99KG5-2 Lsr mouse S288 4771509 PGDFDRTsSVGGHSS X X -Mapk8 JNK1 Q91Y86 mouse STMN2 20257 P55821 Stmn2 mouse S62 450174 ELILKPPsPIsEAPR Stathmin X -Mapk8 JNK1 Q91Y86 mouse BAD 12015 Q61337 Bad mouse S112 447860 ETRsRHssyPAGtEE Bcl-2_BAD X X 9291; 5284; 9296; 5193; 11865; 94223 -Mapk8 JNK1 Q91Y86 mouse PPAR-gamma 19016 P37238 Pparg mouse S112 448062 AIkVEPAsPPYYSEK X -Mapk8 JNK1 Q91Y86 mouse Jun 16476 P05627 Jun mouse T93 450449 GHITTtPtPtQFLCP Jun X X 2993 -Mapk8 JNK1 Q91Y86 mouse RXRA 20181 P28700 Rxra mouse S61 453094 SPISTLSsPINGMGP Nuc_recep-AF1 X -Mapk8 JNK1 Q91Y86 mouse IRX3 16373 P81067 Irx3 mouse S389 1874748506 APPTLQLsPAAAAAA X -Mapk8 JNK1 Q91Y86 mouse STAT3 20848 P42227 Stat3 mouse S727 448191 NtIDLPMsPRTLDSL X 9134; 9136; 34911; 94994; 49081; 58978; 87544; 71958; 50804 -Mapk8 JNK1 Q91Y86 mouse ATF-2 11909 P16951 Atf2 mouse T51 448224 sVIVADQtPtPtRFL X X 9225; 94125; 40749; 61584; 44167 -Mapk8 JNK1 Q91Y86 mouse BAD 12015 Q61337 Bad mouse S128 447861 EGMEEELsPFRGRsR Bcl-2_BAD X -Mapk8 JNK1 Q91Y86 mouse BIM 12125 O54918 Bcl2l11 mouse S65 449330 GPLAPPAsPGPFATR X 4581; 4585 -Mapk8 JNK1 Q91Y86 mouse Jun 16476 P05627 Jun mouse T91 450448 sNGHITTtPtPtQFL Jun X X 2303 -Mapk8 JNK1 Q91Y86 mouse MLP 17357 P28667 Marcksl1 mouse S120 454291 GGDssAssPtEEEQE MARCKS X -Mapk8 JNK1 Q91Y86 mouse RXRA 20181 P28700 Rxra mouse S75 453095 PPFSVISsPMGPHSM Nuc_recep-AF1 X -Mapk8 JNK1 Q91Y86 mouse ELK3 13713 P41971 Elk3 mouse S359 450031 IHFWSSLsPVAPLsP X X -Mapk8 JNK1 Q91Y86 mouse JDP2 81703 P97875 Jdp2 mouse T148 448312 VRTDsVRtPEsEGNP X -Mapk8 JNK1 Q91Y86 mouse Doublecortin 13193 O88809 Dcx mouse S332 451363 StPKsKQsPIStPts X -Mapk8 JNK1 Q91Y86 mouse EEF1A2 1917 Q05639 EEF1A2 human S205 27930804 GDNMLEPsPNMPWFK GTP_EFTU X -Mapk8 JNK1 Q91Y86 mouse RXRA 20181 P28700 Rxra mouse T87 453096 HSMSVPTtPTLGFGT Nuc_recep-AF1 X -Mapk8 JNK1 Q91Y86 mouse BAD 12015 Q61337 Bad mouse T201 450485 NLGKGGStPSQ____ Bcl-2_BAD X X -Mapk8 JNK1 Q91Y86 mouse IRX3 16373 P81067 Irx3 mouse S361 1874748504 SLAETATsPDNPRRS X -Mapk8 JNK1 Q91Y86 mouse IRS1 16367 P35569 Irs1 mouse S307 447558 tEsITAtsPAsMVGG X 2381 -Mapk8 JNK1 Q91Y86 mouse NFAT3 4776 Q14934 NFATC4 human S213 953804 ASRFGLGsPLPsPRA X -Mapk8 JNK1 Q91Y86 mouse H3 iso3 15081 P84244 H3f3b mouse S28 455677 ATkAArksAPSTGGV Histone X 9713 -Mapk8 JNK1 Q91Y86 mouse STMN2 20257 P55821 Stmn2 mouse S73 450173 EAPRTLAsPKKKDLs Stathmin X -Mapk8 JNK1 Q91Y86 mouse Jun 16476 P05627 Jun mouse S63 447686 kNsDLLtsPDVGLLK Jun X X 5464; 9261; 2361; 97721; 91952 -Mapk8 JNK1 Q91Y86 mouse ATF-2 11909 P16951 Atf2 mouse T53 448225 IVADQtPtPtRFLKN X 9225; 9221; 5112; 94125; 13850; 40749; 15411; 24329; 61584; 27934; 92109; 20534; 35858 -Mapk8 JNK1 Q91Y86 mouse p70S6K 6198 P23443 RPS6KB1 human S434 448356 sFEPKIRsPRRFIGs X -Mapk8 JNK1 Q91Y86 mouse JunB 3726 P17275 JUNB human T104 1814000 GVITTtPtPPGQyFy Jun X 8053 -Mapk8 JNK1 Q91Y86 mouse PYCARD 66824 Q9EPB4 Pycard mouse Y144 465096 SVLTEGQyQAVRAET CARD X -Mapk8 JNK1 Q91Y86 mouse MLP 17357 P28667 Marcksl1 mouse T148 454299 QEGKAAAtPEsQEPQ MARCKS X -Mapk8 JNK1 Q91Y86 mouse H2AX 15270 P27661 H2ax mouse S139 448841 GkKAsQAsQEy____ X X 2577; 9719; 9720; 9718; 4309; 5763; 5438; 93629; 80312; 20304; 85410; 97148; 60566; 59141 -Mapk8 JNK1 Q91Y86 mouse BIM 12125 O54918 Bcl2l11 mouse T112 449071 sCDKStQtPsPPCQA X -Mapk8 JNK1 Q91Y86 mouse BMAL1 406 O00327 BMAL1 human T527 448633 sPLNITStPPPDASS X -Mapk8 JNK1 Q91Y86 mouse ELK3 13713 P41971 Elk3 mouse S365 450032 LsPVAPLsPARLQGP X X -Mapk8 JNK1 Q91Y86 mouse STAT1 20846 P42225 Stat1 mouse S727 447753 tDNLLPMsPEEFDEM STAT1_TAZ2bind X 9177; 8826; 62390 -RIOK1 RIOK1 Q9BRS2 human G3BP-2 9908 Q9UN86 G3BP2 human T226 3072179 EELEEKsttPPPAEP X -TNIK TNIK Q9UKE5 human SMAD1 4086 Q15797 SMAD1 human T322 25802105 sNVNRNStIENTRRH MH2 X X -TNIK TNIK Q9UKE5 human TCF7L2 6934 Q9NQB0 TCF7L2 human S177 14918200 QALkDARsPsPAHIV CTNNB1_binding X X -TNIK TNIK Q9UKE5 human Huntingtin 3064 P42858 HTT human S13 10206805 kLMkAFEsLksFQQQ X X -TNIK TNIK Q9UKE5 human Huntingtin 3064 P42858 HTT human T3 10206804 _____MAtLEkLMkA X X -GRK2 GRK2 P21146 cow PDGFRB 5159 P09619 PDGFRB human S1104 454229 PRAEAEDsFL_____ X -GRK2 GRK2 P21146 cow DOR-1 18386 P32300 Oprd1 mouse S363 448550 RVtACtPsDGPGGGA X -GRK2 GRK2 P21146 cow ADRA1B 101843941 P18841 ADRA1B hamster S404 451004 RSQsRKDsLDDsGsC X -GRK2 GRK2 P21146 cow NEDD4 17999 P46935 Nedd4 mouse T470 482846 PPGWEERtHTDGRVF WW X -GRK2 GRK2 P21146 cow ADRB2 154 P07550 ADRB2 human S355 458916 KAyGNGyssNGNtGE X X -GRK2 GRK2 P21146 cow ADRA1B 101843941 P18841 ADRA1B hamster S408 451005 RKDsLDDsGsCMSGS X -GRK2 GRK2 P21146 cow MC4R 4160 P32245 MC4R human S329 449102 LGGLCDLssRY____ X -GRK2 GRK2 P21146 cow MC4R 4160 P32245 MC4R human S330 449103 GGLCDLssRY_____ X -GRK2 GRK2 P21146 cow DOR-1 18386 P32300 Oprd1 mouse T358 449761 AttRERVtACtPsDG X -GRK2 GRK2 P21146 cow ADRB2 154 P07550 ADRB2 human S356 458917 AyGNGyssNGNtGEQ X X -GRK2 GRK2 P21146 cow ADRA1B 101843941 P18841 ADRA1B hamster S410 451006 DsLDDsGsCMSGSQR X -TTBK1 TTBK1 Q5TCY1 human Tau iso8 4137 P10636-8 MAPT human S199 447927 GDRsGyssPGsPGtP X X 29957 -TTBK1 TTBK1 Q5TCY1 human Tau 281296 P29172 MAPT cow S242 449080 VVRTPPKsPSAAKSR X 20473 -TTBK1 TTBK1 Q5TCY1 human Tau 281296 P29172 MAPT cow S403 449081 GAEIVYKsPVVSGDT X -TTBK1 TTBK1 Q5TCY1 human Tau iso8 4137 P10636-8 MAPT human S202 447928 sGyssPGsPGtPGsR X X 39357; 30505 -TTBK1 TTBK1 Q5TCY1 human Tau iso8 4137 P10636-8 MAPT human S198 449551 sGDRsGyssPGsPGt X X -TTBK1 TTBK1 Q5TCY1 human Tau 281296 P29172 MAPT cow S209 447928 sGYSSPGsPGtPGSR X 39357; 30505 -TTBK1 TTBK1 Q5TCY1 human Tau 281296 P29172 MAPT cow S202 450221 SGKSGDRsGYSSPGs X -TTBK1 TTBK1 Q5TCY1 human Tau iso8 4137 P10636-8 MAPT human T427 474503 VDsPQLAtLADEVsA X -TTBK1 TTBK1 Q5TCY1 human Tau iso8 4137 P10636-8 MAPT human Y197 464351 KsGDRsGyssPGsPG X -TTBK1 TTBK1 Q5TCY1 human Tau 281296 P29172 MAPT cow T212 447933 SSPGsPGtPGSRSRT X 25377; 43964; 53001; 49561; 20060; 33032; 30505; 20739; 98160 -TTBK1 TTBK1 Q5TCY1 human Tau 281296 P29172 MAPT cow S411 449082 PVVSGDTsPRHLSNV X 35834; 20194; 98523; 91600; 49562 -TTBK1 TTBK1 Q5TCY1 human Tau iso8 4137 P10636-8 MAPT human S422 449083 GsIDMVDsPQLAtLA X X -TTBK1 TTBK1 Q5TCY1 human Tau iso8 4137 P10636-8 MAPT human S416 454127 sNVsstGsIDMVDsP X 15013; 61160 -Slk SLK O54988 mouse PXN 19303 Q8VI36 Pxn mouse S250 3653284 SsPQRVTsSQQQTRI Paxillin X -Prkg2 PKG2 Q61410 mouse MRVI1 10335 Q9Y6F6 IRAG1 human S689 485352 NMPRRRVsVAVVPKF MRVI1 X -Prkg2 PKG2 Q61410 mouse PKG2 19092 Q61410 Prkg2 mouse S110 450474 LDVHRKtsGLVsLHs X -Prkg2 PKG2 Q61410 mouse PKG2 19092 Q61410 Prkg2 mouse T109 450478 PLDVHRKtsGLVsLH X -Prkg2 PKG2 Q61410 mouse PKG2 19092 Q61410 Prkg2 mouse S126 450477 RGAKAGVsAEPTTRT X -Prkg2 PKG2 Q61410 mouse PKG2 19092 Q61410 Prkg2 mouse S114 450475 RKtsGLVsLHsRRGA X -Prkg2 PKG2 Q61410 mouse PKG2 19092 Q61410 Prkg2 mouse S92 450472 VIHVQGGsPLQAsPD X -Prkg2 PKG2 Q61410 mouse PKG2 19092 Q61410 Prkg2 mouse S117 450473 sGLVsLHsRRGAKAG X -Prkg2 PKG2 Q61410 mouse PKG2 19092 Q61410 Prkg2 mouse S445 450476 KEKVARFsSTSPFQN X -Lyn LYN P25911 mouse Syk 20963 P48025 Syk mouse Y317 447658 STVSFNPyEPtGGPW X 2715 -Lyn LYN P25911 mouse FCGR2A 2212 P12318 FCGR2A human Y304 449552 tDDDKNIyLTLPPND X -Lyn LYN P25911 mouse EPOR 13857 P14753 Epor mouse Y488 457448 DGPySHPyENSLVPD X -Lyn LYN P25911 mouse ZDHHC5 228136 Q8VDZ4 Zdhhc5 mouse Y91 462809 DDFRAPLyKTVEIKG X -Lyn LYN P25911 mouse EPOR 13857 P14753 Epor mouse Y503 449885 SEPLHPGyVACS___ X -Lyn LYN P25911 mouse SHP-1 15170 P29351 Ptpn6 mouse Y564 448912 sKHKEEVyENVHsKS X 8849 -Lyn LYN P25911 mouse TRPV4 63873 Q9EPK8 Trpv4 mouse Y253 448752 IERRCKHyVELLVAQ Ank X X -Lyn LYN P25911 mouse PAG 64019 Q9JM80 Pag1 rat Y381 463949 GEEPEPDyEAIQTLN PAG X -Lyn LYN P25911 mouse DOK2 13449 O70469 Dok2 mouse Y276 452174 LPRPESPySRPHDSL X -Lyn LYN P25911 mouse STAT5A 6776 P42229 STAT5A human Y694 447767 LAkAVDGyVkPQIkQ X 9365; 9356; 9359; 9351; 4322; 9314; 3939; 40284; 5387; 14603; 66740; 51879; 72712 -Lyn LYN P25911 mouse FCER1G 14127 P20491 Fcer1g mouse Y65 451737 REkADAVytGLNTRs ITAM X -Lyn LYN P25911 mouse PKCD 18753 P28867 Prkcd mouse Y332 450077 ILDNNGTyGKIWEGS X -Lyn LYN P25911 mouse p27Kip1 1027 P46527 CDKN1B human Y88 456818 kGsLPEFyyRPPRPP X -Lyn LYN P25911 mouse Syk 20963 P48025 Syk mouse Y342 447659 LPMDTEVyESPyADP X -Lyn LYN P25911 mouse PAG 64019 Q9JM80 Pag1 rat Y409 448996 LVPKENDyESIGDLQ PAG X -Lyn LYN P25911 mouse PAG 64019 Q9JM80 Pag1 rat Y314 450659 EEEISAMysSVNKPG PAG X -Lyn LYN P25911 mouse PAG 94212 Q3U1F9 Pag1 mouse Y386 463949 sEEPEPDyEAIQTLN PAG X X -Lyn LYN P25911 mouse DOK2 13449 O70469 Dok2 mouse Y304 448880 PGAPEGEyAVPFDTV X -Lyn LYN P25911 mouse PHB 18673 P67778 Phb1 mouse Y259 6374000 SRSRNItyLPAGQsV X -Lyn LYN P25911 mouse FCGR2C 9103 P31995 FCGR2C human Y310 449501 tDDDKNIyLTLPPND X -Lyn LYN P25911 mouse FCER1G 14127 P20491 Fcer1g mouse Y76 454847 NTRsQETyEtLkHEk ITAM X -Lyn LYN P25911 mouse DOK2 13449 O70469 Dok2 mouse Y351 447615 APLPDHIyDEPEGVA X 3911 -Lyn LYN P25911 mouse PKCD 18753 P28867 Prkcd mouse Y311 447573 TTEsVGIyQGFEKKP X X 2055 -Lyn LYN P25911 mouse PPP2CA 19052 P63330 Ppp2ca mouse Y307 448571 VTRRtPDyFl_____ X -Lyn LYN P25911 mouse PHB 18673 P67778 Phb1 mouse Y114 6374001 YTsIGEDyDERVLPS Band_7 X -Lyn LYN P25911 mouse SHP-1 15170 P29351 Ptpn6 mouse Y536 448506 QKGQEsEyGNItyPP X -Lyn LYN P25911 mouse LYN 17096 P25911 Lyn mouse Y397 448695 RVIEDNEytAREGAK PK_Tyr_Ser-Thr X X 2101; 6943; 59548; 70926; 78740; 94361; 17320 -Lyn LYN P25911 mouse RAF1 110157 Q99N57 Raf1 mouse Y341 447750 GQRDssyyWEIEASE X -Lyn LYN P25911 mouse Cortactin 13043 Q60598 Cttn mouse Y466 447703 TyTSEPVyETTEAPG X -Lyn LYN P25911 mouse PAG 94212 Q3U1F9 Pag1 mouse Y414 448996 HVPKEsDyEsIGDLQ PAG X X -Lyn LYN P25911 mouse Syk 20963 P48025 Syk mouse Y346 447660 TEVyESPyADPEEIR X 2701; 2717; 14791; 73382; 82975; 31754 -Taok1 TAO1 O88664 rat MARK2 60328 O08679 Mark2 rat T208 449999 TFGNKLDtFCGsPPY Pkinase X X 4836 -MAP3K20 ZAK Q9NYL2 human H3 8350 P68431 H3C1 human S28 455677 ATkAArksAPATGGV Histone X X 9713 -MAP3K20 ZAK Q9NYL2 human ZAK 51776 Q9NYL2 MAP3K20 human T162 455378 sRFHNHttHMsLVGt PK_Tyr_Ser-Thr X X -MAP3K20 ZAK Q9NYL2 human ZAK 51776 Q9NYL2 MAP3K20 human S165 455379 HNHttHMsLVGtFPW PK_Tyr_Ser-Thr X X -MAP3K20 ZAK Q9NYL2 human Chk2 11200 O96017 CHEK2 human T68 447491 SsLEtVstQELYsIP X X 2197; 2661; 28130; 12812; 82263; 64180; 59068 -MAP3K20 ZAK Q9NYL2 human ZAK 51776 Q9NYL2 MAP3K20 human T161 455377 AsRFHNHttHMsLVG PK_Tyr_Ser-Thr X X -MAP3K4 MEKK4 Q9Y6R4 human HOXA10 3206 P31260 HOXA10 human T362 1880104200 FLFNMyLtRERRLEI X X -MAP3K4 MEKK4 Q9Y6R4 human MEKK4 4216 Q9Y6R4 MAP3K4 human T1494 479428 KLKNNAQtMPGEVNS Pkinase X -Prkca PKCA P20444 mouse Vimentin 22352 P20152 Vim mouse S26 451767 GTssRPssNRsYVTT Filament_head X -Prkca PKCA P20444 mouse CD34 12490 Q64314 Cd34 mouse S337 18707502 NGGGQGyssGPGAsP CD34_antigen X -Prkca PKCA P20444 mouse MYBPC1 iso2 109272 G0YZM8 Mybpc1 mouse S204 4738635 IRSAFKRsGEGQEDA X -Prkca PKCA P20444 mouse PRKD1 18760 Q62101 Prkd1 mouse S744 448589 ARIIGEksFRRsVVG Pkinase X 2054 -Prkca PKCA P20444 mouse lamin A/C 16905 P48678 Lmna mouse S5 465449 ___MEtPsQRRAtRs X -Prkca PKCA P20444 mouse CD34 12490 Q64314 Cd34 mouse S343 4733136 yssGPGAsPETQGkA CD34_antigen X -Prkca PKCA P20444 mouse GluR1 14799 P23818 Gria1 mouse S849 448565 FCLIPQQsINEAIRt X 75574 -Prkca PKCA P20444 mouse SHISA7 232813 Q8C3Q5 Shisa7 mouse S417 33636590 LGDGSRAsRYEFTLP X -Prkca PKCA P20444 mouse RAF1 5894 P04049 RAF1 human S497 3082308 AtVksRWsGsQQVEQ PK_Tyr_Ser-Thr X -Prkca PKCA P20444 mouse Ezrin 7430 P15311 EZR human T567 448104 QGRDkyKtLRQIRQG ERM_C X 3141; 3726; 32600 -Prkca PKCA P20444 mouse lamin A/C 16905 P48678 Lmna mouse T416 465451 sQGGGsVtkkRKLEs X -Prkca PKCA P20444 mouse SIK 17691 Q60670 Sik1 mouse S577 465992 FQEGRRAsDTSLTQG X -Prkca PKCA P20444 mouse G-gamma 12 286850 Q28024 GNG12 cow S3 447877 _____MSsKTASTNN X -Prkca PKCA P20444 mouse PLM 56188 Q9Z239 Fxyd1 mouse S88 451425 RssIRRLssRRR___ X -Prkca PKCA P20444 mouse GluR2 14800 P23819 Gria2 mouse S880 448351 yNVyGIEsVKI____ X -Prkca PKCA P20444 mouse HSP27 15507 P14602 Hspb1 mouse S15 448401 FsLLrsPsWEPFRDW X X -Prkca PKCA P20444 mouse KCC2 iso2 57138 Q91V14-2 Slc12a5 mouse S940 487533 ItDEsRGsIRRKNPA SLC12 X X -Prkca PKCA P20444 mouse EGFR 1956 P00533 EGFR human T678 448053 RHIVRKRtLRRLLQE X 14343 -Prkca PKCA P20444 mouse TfR 7037 P02786 TFRC human S24 451671 PLsytRFsLARQVDG X -Prkca PKCA P20444 mouse ER-alpha 13982 P19785 Esr1 mouse S216 12127402 CKAFFKRsIQGHNDY zf-C4 X -Prkca PKCA P20444 mouse TNNI3 21954 P48787 Tnni3 mouse T144 451483 RGKFKRPtLRRVRIs Troponin X -Prkca PKCA P20444 mouse lamin A/C 16905 P48678 Lmna mouse S525 465453 NTWGCGSsLRTALIN LTD X -Prkca PKCA P20444 mouse mGluR7 108073 Q68ED2 Grm7 mouse S862 2846504 NVQKRKRsFKAVVTA X -Prkca PKCA P20444 mouse CBP 12914 P45481 Crebbp mouse S436 447689 CLPLKNAsDKRNQQT X -Prkca PKCA P20444 mouse NRF2 18024 Q60795 Nfe2l2 mouse S40 450082 SREVFDFsQRQKDYE X X -Prkca PKCA P20444 mouse GABRB3 14402 P63080 Gabrb3 mouse S432 450245 KTHLRRRssQLKIKI Neur_chan_memb X -Prkca PKCA P20444 mouse PKCB 18751 P68404 Prkcb mouse T500 447896 WDGVttKtFCGtPDy Pkinase X 9379; 2060; 38938 -Prkca PKCA P20444 mouse Vimentin 22352 P20152 Vim mouse S7 455449 _MSTRsVssssYRRM Filament_head X -Prkca PKCA P20444 mouse Vimentin 22352 P20152 Vim mouse S21 455452 MFGGsGTssRPssNR Filament_head X -Prkca PKCA P20444 mouse lamin A/C 16905 P48678 Lmna mouse S652 465465 RsyLLGNssPRSQSS X -Prkca PKCA P20444 mouse PPP1R1A 58200 Q9ERT9 Ppp1r1a mouse S67 447758 LKSTLsMsPRQRKKM DARPP-32 X -Prkca PKCA P20444 mouse Vimentin 22352 P20152 Vim mouse S10 455451 TRsVssssYRRMFGG Filament_head X -Prkca PKCA P20444 mouse Vimentin 22352 P20152 Vim mouse S34 455454 NRsYVTTsTRTysLG Filament_head X -Prkca PKCA P20444 mouse TNNI3 21954 P48787 Tnni3 mouse S24 448424 APVRRRssANyRAYA Troponin-I_N X -Prkca PKCA P20444 mouse MYBPC1 iso2 109272 G0YZM8 Mybpc1 mouse T84 21560211 NANSQLstLFVEKPQ I-set X -Prkca PKCA P20444 mouse lamin A/C 16905 P48678 Lmna mouse T199 465450 DAENRLQtLkEELDF Filament X -Prkca PKCA P20444 mouse NR2C1 22025 Q505F1 Nr2c1 mouse S568 456552 IGNVRIDsVIPHILK X -Prkca PKCA P20444 mouse PITPNB 56305 P53811 Pitpnb mouse S262 451299 ETMRKKGsVRGTsAA X X -Prkca PKCA P20444 mouse AR 11835 P19091 Ar mouse S794 1875398900 MKALLLFsIIPVDGL Hormone_recep X -Prkca PKCA P20444 mouse Rhodopsin 212541 P15409 Rho mouse S338 448679 DDAsATAsKtEtsQV X -Prkca PKCA P20444 mouse Rhodopsin 212541 P15409 Rho mouse S334 448677 PLGDDDAsATAsKtE X -Prkca PKCA P20444 mouse PKCA 18750 P20444 Prkca mouse S657 448597 QsDFEGFsyVNPQFV Pkinase_C X 9371 -Prkca PKCA P20444 mouse JPH2 59091 Q9ET78 Jph2 mouse S165 4779179 PLRtsLSsLRSEHSN X -Prkca PKCA P20444 mouse GABRB3 14402 P63080 Gabrb3 mouse S433 450246 THLRRRssQLKIKIP Neur_chan_memb X -Prkca PKCA P20444 mouse AQP4 11829 P55088 Aqp4 mouse S180 467301 TIFASCDsKRTDVTG MIP X -Prkca PKCA P20444 mouse NHERF 26941 P70441 Nherf1 mouse S77 957200 ETHQQVVsRIRAALN PDZ X -Prkca PKCA P20444 mouse APPL 26060 Q9UKG1 APPL1 human S430 13204434 ARTSssGsLGSESTN X -Prkca PKCA P20444 mouse Vimentin 22352 P20152 Vim mouse S51 449416 LRPstsRsLysssPG Filament_head X -Prkca PKCA P20444 mouse HSP27 15507 P14602 Hspb1 mouse S86 448403 RALNRQLssGVsEIR X X 2406; 2401; 9709; 11892; 64293 -Prkca PKCA P20444 mouse fascin 14086 Q61553 Fscn1 mouse S39 450888 KVNASAssLkkKQIW Fascin X -Prkca PKCA P20444 mouse STX7 53331 O70439 Stx7 mouse S125 468880 FVARVRAssRVsGGF X -Prkca PKCA P20444 mouse GRK2 25238 P26817 Grk2 rat S29 447724 ATPAARAsKKILLPE X -Prkca PKCA P20444 mouse TNNI3 21954 P48787 Tnni3 mouse S45 450691 KKSKIsAsRKLQLkT X -Prkca PKCA P20444 mouse CD34 12490 Q64314 Cd34 mouse S338 15408590 GGGQGyssGPGAsPE CD34_antigen X -Prkca PKCA P20444 mouse PITPNB 56305 P53811 Pitpnb mouse S165 451298 EDPALFHsVKTKRGP IP_trans X -Prkca PKCA P20444 mouse Vimentin 22352 P20152 Vim mouse S42 451789 TRTysLGsALRPsts Filament_head X -Prkca PKCA P20444 mouse SHISA7 232813 Q8C3Q5 Shisa7 mouse S317 1872500601 STLSCSRsFHNLSHL X -Prkca PKCA P20444 mouse Vimentin 22352 P20152 Vim mouse S25 455453 sGTssRPssNRsYVT Filament_head X -Prkca PKCA P20444 mouse PPFIA3 140591 Q91Z79 Ppfia3 rat S760 1873117000 HKAPKRKsIKssIGR X X -Prkca PKCA P20444 mouse PKCA 18750 P20444 Prkca mouse T497 448598 MDGVttRtFCGtPDy Pkinase X 9379; 2060; 38938 -Prkca PKCA P20444 mouse GJA1 24392 P08050 Gja1 rat S368 447813 QRPssRAssRAssRP X 3511; 52559 -Prkca PKCA P20444 mouse Vimentin 22352 P20152 Vim mouse S39 451766 TTsTRTysLGsALRP Filament_head X 13614 -Prkca PKCA P20444 mouse KCNE1 25471 P15383 Kcne1 rat S103 10349700 FQARVLEsFRACYVI ISK_Channel X -Prkca PKCA P20444 mouse TMPO 21917 Q61029 Tmpo mouse S179 451480 RQNGsNDsDRysDND X -Prkca PKCA P20444 mouse NPHS1 54631 Q9QZS7 Nphs1 mouse T1139 18507017 QWtGDRDtRSSTVST X -Prkca PKCA P20444 mouse NPHS1 54631 Q9QZS7 Nphs1 mouse T1134 18507016 EYEESQWtGDRDtRS X -Prkca PKCA P20444 mouse CREM 12916 P27699 Crem mouse S133 448412 EILSRRPsYRKILNE pKID X 4095; 14228; 14001 -Prkca PKCA P20444 mouse SNAP-25 20614 P60879 Snap25 mouse S187 448668 RIMEkADsNkTRIDE X -Prkca PKCA P20444 mouse GluR1 14799 P23818 Gria1 mouse T858 3362100 NEAIRtstLPRNsGA X X -Prkca PKCA P20444 mouse TNNI3 21954 P48787 Tnni3 mouse S23 448423 PAPVRRRssANyRAY Troponin-I_N X -Prkca PKCA P20444 mouse AYTL1 270084 Q8BYI6 Lpcat2 mouse S34 15146101 PMVPRQAsFFPPPVP X -Prkca PKCA P20444 mouse DLX3 13393 Q64205 Dlx3 mouse S138 455813 KPRTIYSsYQLAALQ Homeodomain X -Prkca PKCA P20444 mouse Vimentin 22352 P20152 Vim mouse S66 451765 GAyVtRssAVRLRss Filament_head X -Prkca PKCA P20444 mouse Akt1 11651 P31750 Akt1 mouse S473 447855 RPHFPQFsysAsGtA Pkinase_C X 9271; 3787; 4060; 4051; 5102; 4058; 2336; 2337; 4075; 4070; 5012; 4071; 92982; 5315; 9563; 9018; 12694; 52240; 11962; 15116; 88106; 26580; 68035; 31957; 23430; 20235 -Prkca PKCA P20444 mouse RAF1 5894 P04049 RAF1 human S619 5822317 sLPKINRsAsEPsLH X -Prkca PKCA P20444 mouse lamin A/C 16905 P48678 Lmna mouse T480 465452 NGDDPLMtYRFPPKF LTD X -Prkca PKCA P20444 mouse PEA-15 18611 Q62048 Pea15 mouse S104 455750 TkLtRIPsAKKyKDI X X 2776 -Prkca PKCA P20444 mouse CD34 12490 Q64314 Cd34 mouse S371 18707501 ATSRNGHsARQHVVA CD34_antigen X -Prkca PKCA P20444 mouse MYBPC1 iso2 109272 G0YZM8 Mybpc1 mouse S83 21560212 QNANSQLstLFVEKP X -Prkca PKCA P20444 mouse NR2C1 22025 Q505F1 Nr2c1 mouse S461 456551 MSPERRKsLMEHIFK Hormone_recep X -Prkca PKCA P20444 mouse Vimentin 22352 P20152 Vim mouse S9 455450 STRsVssssYRRMFG Filament_head X -Prkca PKCA P20444 mouse TNNI3 21954 P48787 Tnni3 mouse S43 450690 AkKKSKIsAsRKLQL X -Prkca PKCA P20444 mouse IRS1 25467 P35570 Irs1 rat S24 455604 GYLRKPKsMHKRFFV PH X -Prkca PKCA P20444 mouse KLHL3 100503085 E0CZ16 Klhl3 mouse S433 36440206 PMNTRRSsVGVGVVE Kelch_1 X -Prkca PKCA P20444 mouse CD34 12490 Q64314 Cd34 mouse S313 18707500 YFLMNRRsWSPTGER CD34_antigen X -Prkca PKCA P20444 mouse TDG 21665 P56581 Tdg mouse S99 11509300 TSkksGksTKSKEKQ X X -Prkca PKCA P20444 mouse TDG 21665 P56581 Tdg mouse S96 11509301 KPATSkksGksTKSK X X -Prkca PKCA P20444 mouse RXRA 20181 P28700 Rxra mouse T167 1868546605 CKGFFKRtVRKDLTY zf-C4 X -Prkca PKCA P20444 mouse GluR2 29627 P19491 Gria2 rat S880 448351 yNVyGIEsVkI____ X -Stk39 STLK3 Q9Z1W9 mouse NCCT 20497 P59158 Slc12a3 mouse T58 469617 MRtFGYNtIDVVPAY AA_permease_N X -Stk39 STLK3 Q9Z1W9 mouse STLK3 53416 Q9Z1W9 Stk39 mouse T247 458885 VRKtFVGtPCWMAPE Pkinase X -Stk39 STLK3 Q9Z1W9 mouse STLK3 53416 Q9Z1W9 Stk39 mouse T243 456505 tRNKVRKtFVGtPCW Pkinase X -Ptk2 FAK P34152 mouse YAP1 10413 P46937 YAP1 human S397 3190672 tyHSRDEstDsGLsM X -Ptk2 FAK P34152 mouse FAK 14083 P34152 Ptk2 mouse Y397 447887 sVsEtDDyAEIIDEE X 3283; 8556 -Ptk2 FAK P34152 mouse TAK1 26409 Q62073 Map3k7 mouse S412 455196 NGQPRRRsIQDLtVT X 9339 -Ptk2 FAK P34152 mouse EphA2 13836 Q03145 Epha2 mouse Y773 450861 EDDPEAtyTtsGGKI PK_Tyr_Ser-Thr X 8244; 8862 -Ptk2 FAK P34152 mouse GSK3B 56637 Q9WV60 Gsk3b mouse Y216 448569 RGEPNVsyICsRYYR Pkinase X -Prkaca PKACA P05132 mouse MYBPC1 iso2 109272 G0YZM8 Mybpc1 mouse S204 4738635 IRSAFKRsGEGQEDA X -Prkaca PKACA P05132 mouse HSP20 243912 Q5EBG6 Hspb6 mouse S16 450706 PsWLRRAsAPLPGFS Crystallin X 36519 -Prkaca PKACA P05132 mouse FLNC 68794 Q8VHX6 Flnc mouse S2625 15403523 sSSsRGAsySSIPKF X -Prkaca PKACA P05132 mouse HSL 16890 P54310 Lipe mouse S557 448803 PtESMRRsVsEAALA X 4139 -Prkaca PKACA P05132 mouse MARCKS 17118 P26645 Marcks mouse S160 466360 FKKsFkLsGFsFKKs MARCKS X 8722 -Prkaca PKACA P05132 mouse Spinophilin 217124 Q6R891 Ppp1r9b mouse S94 448728 SDRGVRLsLPRAssL X -Prkaca PKACA P05132 mouse SHISA7 232813 Q8C3Q5 Shisa7 mouse T366 1872500602 QLEMPRGtLPLHALR X -Prkaca PKACA P05132 mouse GluR1 14799 P23818 Gria1 mouse S849 448565 FCLIPQQsINEAIRt X 75574 -Prkaca PKACA P05132 mouse SHISA7 232813 Q8C3Q5 Shisa7 mouse S417 33636590 LGDGSRAsRYEFTLP X -Prkaca PKACA P05132 mouse AMPKA1 105787 Q5EG47 Prkaa1 mouse S496 450431 AtPQRsGsIsNYRsC AdenylateSensor X 4185; 4184; 2537 -Prkaca PKACA P05132 mouse CRMP-2 12934 O08553 Dpysl2 mouse T555 448084 DNIPRRttQRIVAPP X -Prkaca PKACA P05132 mouse HSL 3991 Q05469 LIPE human S951 450195 GFHPRRssQGAtQMP Abhydrolase_3 X -Prkaca PKACA P05132 mouse nAChRA7 11441 P49582 Chrna7 mouse S365 451182 QHKPRRCsLASVELS Neur_chan_memb X -Prkaca PKACA P05132 mouse smMLCK 396445 P11799 MYLK chicken S140 41411900 KTPGGRLsVPPVEHR X -Prkaca PKACA P05132 mouse PTRF 19285 O54724 Cavin1 mouse S368 452129 tDLLRGssPDVHtLL X -Prkaca PKACA P05132 mouse IP3R1 16438 P11881 Itpr1 mouse S1588 450681 RNAARRDsVLAAsRD X -Prkaca PKACA P05132 mouse NFAT2 4772 O95644 NFATC1 human S245 448861 PSTsPRAsVTEEsWL X -Prkaca PKACA P05132 mouse LDB3 24131 Q9JKS4 Ldb3 mouse S265 10364530 DEWARRSsNLQSRSF DUF4749 X -Prkaca PKACA P05132 mouse perilipin 1 25629 P43884 Plin1 rat S277 450081 QVVSRRQsEVRVPWL Perilipin X -Prkaca PKACA P05132 mouse GJD2 14617 O54851 Gjd2 mouse S293 471387 GAQAKRKsVYEIRNK X -Prkaca PKACA P05132 mouse SIK 17691 Q60670 Sik1 mouse S577 465992 FQEGRRAsDTSLTQG X -Prkaca PKACA P05132 mouse MLPH 171531 Q91V27 Mlph mouse S498 7103618 sGKPRRKsGIPIFLP Rab_eff_C X -Prkaca PKACA P05132 mouse GluR1 14799 P23818 Gria1 mouse S863 448566 tstLPRNsGAGASGG X X 8084 -Prkaca PKACA P05132 mouse PLCL1 227120 Q3USB7 Plcl1 mouse T94 453436 KCGGRKKtVsFSSMP X -Prkaca PKACA P05132 mouse perilipin 1 25629 P43884 Plin1 rat S81 450079 EPVVRRLsTQFTAAN Perilipin X -Prkaca PKACA P05132 mouse SLC29A1 63959 Q9JIM1 Slc29a1 mouse S266 21326703 PKGRREEsGVPGPNs Nucleoside_tran X -Prkaca PKACA P05132 mouse CITED1 12705 P97769 Cited1 mouse S79 8112774 GsPTATPssKPPsFN CITED X -Prkaca PKACA P05132 mouse MARCKS 17118 P26645 Marcks mouse S163 451837 sFkLsGFsFKKsKKE MARCKS X 8722 -Prkaca PKACA P05132 mouse NMDAR2B 14812 Q01097 Grin2b mouse Y1472 448167 GSSNGHVyEKLSSIE NMDAR2_C X 4208 -Prkaca PKACA P05132 mouse NFAT2 4772 O95644 NFATC1 human S269 448862 PCNKRKYsLNGRQPP X -Prkaca PKACA P05132 mouse KIFAP3 16579 P70188 Kifap3 mouse S102 18260847 YLQNRRDsLPGKEKK KAP X -Prkaca PKACA P05132 mouse ABHD5 67469 Q9DBL9 Abhd5 mouse S239 36744500 PDFKRKYsSMFEDDT X -Prkaca PKACA P05132 mouse RAF1 110157 Q99N57 Raf1 mouse S233 448651 AsSQHRYstPHAFTF X -Prkaca PKACA P05132 mouse SLC29A1 63959 Q9JIM1 Slc29a1 mouse S281 21326706 PPtNRNQsIKAILKs Nucleoside_tran X -Prkaca PKACA P05132 mouse ARPP-21 74100 Q9DCB4 Arpp21 mouse S57 448050 QERRKsksGAGkGkL X X -Prkaca PKACA P05132 mouse perilipin 1 103968 Q8CGN5 Plin1 mouse S492 459628 EKPARRVsDsFFRPs X -Prkaca PKACA P05132 mouse SNAP-25 20614 P60879 Snap25 mouse T138 449875 GGFIRRVtNDARENE SNAP-25 X -Prkaca PKACA P05132 mouse CDC25B 12531 P30306 Cdc25b mouse S321 448409 QRLFRsPsMPCSVIR M-inducer_phosp X -Prkaca PKACA P05132 mouse HSP27 15507 P14602 Hspb1 mouse S15 448401 FsLLrsPsWEPFRDW X X -Prkaca PKACA P05132 mouse PPP2R5D 21770 Q7TNL5 Ppp2r5d mouse S68 457389 QLSKIKYsGGPQIVK X -Prkaca PKACA P05132 mouse SPTBN1 20742 Q62261 Sptbn1 mouse T346 451391 QQLQAFNtYRTVEKP Spectrin X -Prkaca PKACA P05132 mouse ARHGAP14 259302 Q812A2 Srgap3 mouse S858 3175109 MGRVRLRsDGAAIPR X -Prkaca PKACA P05132 mouse TIAM2 24001 Q6ZPF3 Tiam2 mouse S782 19003600 KGREKRAsITQMFDS X -Prkaca PKACA P05132 mouse RASGRF1 19417 P27671 Rasgrf1 mouse S822 450230 LSASRKHsSDVLKEE X -Prkaca PKACA P05132 mouse HDAC4 9759 P56524 HDAC4 human S265 4737971 QKVAERRssPLLRRK X -Prkaca PKACA P05132 mouse GABRA2 14395 P26048 Gabra2 mouse S359 1869636101 DKKKEKGsVMIQNNA X X -Prkaca PKACA P05132 mouse STMN1 3925 P16949 STMN1 human S63 448557 AAEERRksHEAEVLk Stathmin X -Prkaca PKACA P05132 mouse melanopsin 30044 Q9QXZ9 Opn4 mouse T186 26415701 GRGsKRRtALVLLGV 7tm_1 X -Prkaca PKACA P05132 mouse SHISA7 232813 Q8C3Q5 Shisa7 mouse S405 3989799 PNPRRVMsQEHLLGD X -Prkaca PKACA P05132 mouse HDAC4 9759 P56524 HDAC4 human S266 4737976 KVAERRssPLLRRKD X -Prkaca PKACA P05132 mouse COX4I1 12857 P19783 Cox4i1 mouse S58 479944 HVTMLsAsQkALKEk COX4 X -Prkaca PKACA P05132 mouse LDB3 24131 Q9JKS4 Ldb3 mouse S296 28850313 EEALRRSsTPIEHAP X -Prkaca PKACA P05132 mouse MYBPC3 17868 O70468 Mybpc3 mouse T65 30324203 AAEGkRHtLTVRDAs I-set X -Prkaca PKACA P05132 mouse SIRT1 93759 Q923E4 Sirt1 mouse S434 22568200 LLIVIGSsLKVRPVA SIR2 X -Prkaca PKACA P05132 mouse PTP-SL iso2 19279 Q62132-2 Ptprr mouse S231 31949800 GLQERRGsNVSLTLD X -Prkaca PKACA P05132 mouse SLC43A2 215113 Q8CGA3 Slc43a2 mouse S274 2508983 TTVGRRLsVGssMRt MFS_1 X -Prkaca PKACA P05132 mouse Fos 14281 P01101 Fos mouse S362 448481 AAAHRKGsSSNEPSS X -Prkaca PKACA P05132 mouse PPP2R5D 21770 Q7TNL5 Ppp2r5d mouse S566 457390 KVLLRRKsELPQDVy X -Prkaca PKACA P05132 mouse SHISA7 232813 Q8C3Q5 Shisa7 mouse S430 480319 LPRARLVsQEHLLLs X -Prkaca PKACA P05132 mouse MOS 17451 P00536 Mos mouse S25 448659 SVDSRSCsIPLVAPR X X -Prkaca PKACA P05132 mouse BAD 12015 Q61337 Bad mouse S112 447860 ETRsRHssyPAGtEE Bcl-2_BAD X X 9291; 5284; 9296; 5193; 11865; 94223 -Prkaca PKACA P05132 mouse PPP1R1A 58200 Q9ERT9 Ppp1r1a mouse T35 447759 QIRRRRPtPATLVLt DARPP-32 X -Prkaca PKACA P05132 mouse APOBEC3G 60489 Q9HC16 APOBEC3G human T218 21656100 WVRGRHEtyLCYEVE NAD2 X -Prkaca PKACA P05132 mouse RAF1 5894 P04049 RAF1 human S259 447741 sQRQRststPNVHMV X 9421; 20011 -Prkaca PKACA P05132 mouse CDK18 18557 Q04899 Cdk18 mouse S66 2192678 RQNQRRFsMEDLNKR X X -Prkaca PKACA P05132 mouse H1E 3008 P10412 H1-4 human S36 456059 GAAkRkAsGPPVsEL X -Prkaca PKACA P05132 mouse MYBPC3 17868 O70468 Mybpc3 mouse S47 4699355 VRWQRDGsDItANDK I-set X -Prkaca PKACA P05132 mouse NLRP3 114548 Q96P20 NLRP3 human S295 57761902 HKIVRKPsRILFLMD NACHT X -Prkaca PKACA P05132 mouse MYBPC1 iso2 109272 G0YZM8 Mybpc1 mouse S59 21560210 RALERKDsEWsLGES X -Prkaca PKACA P05132 mouse PKACA 18747 P05132 Prkaca mouse S339 449886 EEEEIRVsINEKCGK X -Prkaca PKACA P05132 mouse STEP 19259 P54830 Ptpn5 mouse S221 448294 GLQERRGsNVSLTLD X 5659 -Prkaca PKACA P05132 mouse Vimentin 22352 P20152 Vim mouse S7 455449 _MSTRsVssssYRRM Filament_head X -Prkaca PKACA P05132 mouse ASK1 26408 O35099 Map3k5 mouse S973 447736 NEYLRSIsLPVPVLV X 3764 -Prkaca PKACA P05132 mouse PLCL1 227120 Q3USB7 Plcl1 mouse S96 453437 GGRKKtVsFSSMPSE X -Prkaca PKACA P05132 mouse perilipin 1 103968 Q8CGN5 Plin1 mouse S517 471365 YsQLRKKs_______ X -Prkaca PKACA P05132 mouse CDC25B 12531 P30306 Cdc25b mouse S149 7998663 FTIKRFRsLPVRLLE M-inducer_phosp X -Prkaca PKACA P05132 mouse BANP 53325 Q8VBU8 Banp mouse S347 475059 SFSRRTPsSSSYSAS X -Prkaca PKACA P05132 mouse ATF-4 11911 Q06507 Atf4 mouse S218 448436 DTPSDNDsGICMSPE X -Prkaca PKACA P05132 mouse AurC 20871 O88445 Aurkc mouse T171 455456 TPSLRRKtMCGtLDY Pkinase X 2914; 13464; 8525 -Prkaca PKACA P05132 mouse PPP1R3A 100009140 Q00756 RG1 rabbit S48 449320 PQPSRRGsESSEEVY X -Prkaca PKACA P05132 mouse LKB1 20869 Q9WTK7 Stk11 mouse S431 448147 sNKIRRLsACKQQ__ X X 3482 -Prkaca PKACA P05132 mouse MYBPC3 295929 P56741 Mybpc3 rat S279 471079 RSAFRRTsLAGTGRR X X -Prkaca PKACA P05132 mouse MARCKS 17118 P26645 Marcks mouse S152 447786 kkKKKRFsFKKsFkL MARCKS X 2741; 11992 -Prkaca PKACA P05132 mouse ARX 11878 O35085 Arx mouse S266 1869973800 LKEPRRCsVATTGTV X -Prkaca PKACA P05132 mouse USP20 74270 Q8C6M1 Usp20 mouse S334 7323248 RMKDRKFsWGQQRTN X -Prkaca PKACA P05132 mouse PLB 18821 P61014 Pln mouse T17 448115 SAIRRAstIEMPQQA Phospholamban X 8496 -Prkaca PKACA P05132 mouse AKAP9 10142 Q99996 AKAP9 human S43 456204 QkKKRKTsSsKHDVS X -Prkaca PKACA P05132 mouse Kv4.2 16508 Q9Z0V2 Kcnd2 mouse S552 450462 VsGsHRGsVQELSTI X X -Prkaca PKACA P05132 mouse SLC29A1 63959 Q9JIM1 Slc29a1 mouse S288 21326707 sIKAILKsICVPALS Nucleoside_tran X -Prkaca PKACA P05132 mouse TNNI3 21954 P48787 Tnni3 mouse S24 448424 APVRRRssANyRAYA Troponin-I_N X X -Prkaca PKACA P05132 mouse TPH1 100009100 P17290 TPH1 rabbit S58 451575 RKSKRRNsEFEIFVD X -Prkaca PKACA P05132 mouse PLB 18821 P61014 Pln mouse S16 448114 RSAIRRAstIEMPQQ Phospholamban X 8496 -Prkaca PKACA P05132 mouse Lasp-1 16796 Q61792 Lasp1 mouse T156 454432 SSSYRRPtEQQQPQP X -Prkaca PKACA P05132 mouse WEE1B 381759 Q66JT0 Wee2 mouse S15 456697 QGLNKKLsFSFCEED X -Prkaca PKACA P05132 mouse GLUL 14645 P15105 Glul mouse S343 467948 yFEDRRPsANCDPYA X X -Prkaca PKACA P05132 mouse HSL 16890 P54310 Lipe mouse S559 448804 ESMRRsVsEAALAQP X 4137 -Prkaca PKACA P05132 mouse HNF4 alpha 15378 P49698 Hnf4a mouse S143 458369 RIStRRssYEDSsLP X -Prkaca PKACA P05132 mouse MOS 17451 P00536 Mos mouse S71 450039 CLMHRLGsGGFGSVY Pkinase X X -Prkaca PKACA P05132 mouse SHISA7 232813 Q8C3Q5 Shisa7 mouse S306 19014882 AMPPPsPsLHYSTLS X -Prkaca PKACA P05132 mouse RAF1 5894 P04049 RAF1 human S621 447746 PKINRsAsEPsLHRA X X -Prkaca PKACA P05132 mouse QIK 235344 Q8CFH6 Sik2 mouse S587 3212040 FREGRRAsDtsLTQG X -Prkaca PKACA P05132 mouse QSK 70661 Q6P4S6 Sik3 mouse S609 1868968411 QRYLANRsKRHTLAM X -Prkaca PKACA P05132 mouse BAD 12015 Q61337 Bad mouse S155 447863 GRELRRMsDEFEGsF Bcl-2_BAD X X 9297 -Prkaca PKACA P05132 mouse melanopsin 30044 Q9QXZ9 Opn4 mouse S287 26415700 RQWQRLQsEWKMAKV 7tm_1 X -Prkaca PKACA P05132 mouse perilipin 5 66968 Q8BVZ1 Plin5 mouse S155 8095494 AQRGRRWsGELRRsM Perilipin X X -Prkaca PKACA P05132 mouse NHERF 26941 P70441 Nherf1 mouse S77 957200 ETHQQVVsRIRAALN PDZ X -Prkaca PKACA P05132 mouse Vimentin 22352 P20152 Vim mouse S51 449416 LRPstsRsLysssPG Filament_head X -Prkaca PKACA P05132 mouse PKACA 18747 P05132 Prkaca mouse T198 448459 RVKGRtWtLCGtPEY Pkinase X 4781; 5661 -Prkaca PKACA P05132 mouse HSP27 15507 P14602 Hspb1 mouse S86 448403 RALNRQLssGVsEIR X X 2406; 2401; 9709; 11892; 64293 -Prkaca PKACA P05132 mouse RHOA 387 P61586 RHOA human S188 449035 ARRGKKKsGCLVL__ X X -Prkaca PKACA P05132 mouse Kv4.2 16508 Q9Z0V2 Kcnd2 mouse T38 450461 PRQERKRtQDALIVL X X -Prkaca PKACA P05132 mouse CACNA1C iso5 12288 Q0PCR6 Cacna1c mouse S1927 455278 ASLGRRAsFHLECLK CAC1F_C X -Prkaca PKACA P05132 mouse DARPP-32 19049 Q60829 Ppp1r1b mouse T34 448047 MIRRRRPtPAMLFRV DARPP-32 X X 12438 -Prkaca PKACA P05132 mouse CAMK1D iso2 227541 Q8BW96-2 Camk1d mouse S349 7101531 SFLLRRGsQESELRG X X -Prkaca PKACA P05132 mouse GJD2 14617 O54851 Gjd2 mouse S315 471389 PNFGRTQsSDSAYV_ X -Prkaca PKACA P05132 mouse AQP0 17339 P51180 Mip mouse S235 450116 KSVSERLsILKGARP X -Prkaca PKACA P05132 mouse NLGN1 192167 Q99K10 Nlgn1 mouse S839 1868546601 HPHPHSHsTTRV___ X X -Prkaca PKACA P05132 mouse CREB 1385 P16220 CREB1 human S119 448228 EILsRRPsyRkILND pKID X X 9187; 9196; 9198; 4095; 14228; 14001; 39561; 80120; 44864; 54960; 95995 -Prkaca PKACA P05132 mouse MOS 17451 P00536 Mos mouse S232 450040 DLRCRQAsPHHIGGT Pkinase X X -Prkaca PKACA P05132 mouse ADAM22 11496 Q9R1V6 Adam22 mouse S855 469109 RFRPRsNsTEtLsPA X -Prkaca PKACA P05132 mouse MYBPC3 17868 O70468 Mybpc3 mouse S282 471080 AGAGRRtsDsHEDAG X -Prkaca PKACA P05132 mouse KCNK18 332396 Q6VV64 Kcnk18 mouse S264 2712200 RPVERSNsCPELVLG X -Prkaca PKACA P05132 mouse TRPC6 22068 Q61143 Trpc6 mouse S28 22280200 AGTRRNEsQDYLLMD X -Prkaca PKACA P05132 mouse PKD1 18763 O08852 Pkd1 mouse S4159 457387 PSRSSRGsKSSPVVL X -Prkaca PKACA P05132 mouse RASGRF1 19417 P27671 Rasgrf1 mouse S745 450229 PsRRRKLsLNIPIIT RasGEF_N X -Prkaca PKACA P05132 mouse NFkB-p65 19697 Q04207 Rela mouse S276 447798 SMQLRRPsDRELSEP RHD_dimer X X -Prkaca PKACA P05132 mouse CHCHD3 66075 Q9CRB9 Chchd3 mouse T11 4038300 TASTRRVtFEADENE X -Prkaca PKACA P05132 mouse SHISA7 232813 Q8C3Q5 Shisa7 mouse S317 1872500601 STLSCSRsFHNLSHL X -Prkaca PKACA P05132 mouse ASK1 26408 O35099 Map3k5 mouse S993 7449405 SSEYGSVsPDTELKA X -Prkaca PKACA P05132 mouse GATA4 54254 P46152 Gata4 rat S261 450013 IKPQRRLsASRRVGL X -Prkaca PKACA P05132 mouse HSL 16890 P54310 Lipe mouse S651 450195 GFHPRRssQGVLHMP Abhydrolase_3 X 4126; 45804 -Prkaca PKACA P05132 mouse PGC-1 alpha 19017 O70343 Ppargc1a mouse S241 13861602 KCASKKKsHTQPQSQ X -Prkaca PKACA P05132 mouse NFM 18040 P08553 Nefm mouse S23 452024 RVTEtRSsFSrVsGs Filament_head X -Prkaca PKACA P05132 mouse PTRF 19285 O54724 Cavin1 mouse S171 485274 LPAkLsVsksLkEsE PTRF_SDPR X -Prkaca PKACA P05132 mouse CSF2RB 1439 P32927 CSF2RB human S601 448463 LGPPHSRsLPDILGQ X X -Prkaca PKACA P05132 mouse melanopsin 30044 Q9QXZ9 Opn4 mouse S182 26415702 LATIGRGsKRRtALV 7tm_1 X -Prkaca PKACA P05132 mouse smMLCK 396445 P11799 MYLK chicken S149 17555039 PPVEHRPsIWGESPP X -Prkaca PKACA P05132 mouse BNIP3 12176 O55003 Bnip3 mouse T181 41388500 IYIGRRLtTSTSTF_ BNIP3 X -Prkaca PKACA P05132 mouse RAF1 5894 P04049 RAF1 human S43 447744 FGyQRRAsDDGKLtD X -Prkaca PKACA P05132 mouse SNAPIN 20615 Q9Z266 Snapin mouse S50 448453 HVHAVREsQVELREQ Snapin_Pallidin X -Prkaca PKACA P05132 mouse MEF2D 17261 Q63943 Mef2d mouse S190 2246701 QPALQRNsVsPGLPQ X -Prkaca PKACA P05132 mouse AIDA 108909 Q8C4Q6 Aida mouse S161 15495718 TLLPRLPsEPGMtLL Aida_C2 X X -Prkaca PKACA P05132 mouse MYBPC3 17868 O70468 Mybpc3 mouse T290 4699397 DsHEDAGtPDFSsLL X -Prkaca PKACA P05132 mouse Vimentin 22352 P20152 Vim mouse S25 455453 sGTssRPssNRsYVT Filament_head X -Prkaca PKACA P05132 mouse PLCL1 5334 Q15111 PLCL1 human T246 467202 PRFMWLKtVFEAADV X -Prkaca PKACA P05132 mouse MYBPC1 iso2 109272 G0YZM8 Mybpc1 mouse S62 21560209 ERKDsEWsLGESPAG X -Prkaca PKACA P05132 mouse Kir6.2 16514 Q61743 Kcnj11 mouse T224 453090 MQVVRKTtSPEGEVV IRK_C X -Prkaca PKACA P05132 mouse TEAD1 21676 P30051 Tead1 mouse S102 450655 QVLARRKsRDFHSKL X X -Prkaca PKACA P05132 mouse Vimentin 22352 P20152 Vim mouse S39 451766 TTsTRTysLGsALRP Filament_head X 13614 -Prkaca PKACA P05132 mouse PPP1R3A 140491 Q99MR9 Ppp1r3a mouse S67 449321 TSASRRVsFADsLGF X -Prkaca PKACA P05132 mouse PPP2R5D 21770 Q7TNL5 Ppp2r5d mouse S53 457388 PssNKRPsNStPPPT X -Prkaca PKACA P05132 mouse CEACAM1 81613 P16573 Ceacam1 rat S449 22636602 ALAYFLYsRKTGGGS X -Prkaca PKACA P05132 mouse PHLPP2 244650 Q8BXA7 Phlpp2 mouse S1116 17546653 PRPERRCsLHPASsA X -Prkaca PKACA P05132 mouse CREM 12916 P27699 Crem mouse S133 448412 EILSRRPsYRKILNE pKID X 4095; 14228; 14001 -Prkaca PKACA P05132 mouse HSL 3991 Q05469 LIPE human S853 448803 IAEPMRRsVsEAALA X 4139 -Prkaca PKACA P05132 mouse GJD2 14617 O54851 Gjd2 mouse S306 471388 NKDLPRVsVPNFGRT X -Prkaca PKACA P05132 mouse SNAPIN 295217 P60192 Snapin rat S50 448453 HVHAVREsQVELREQ Snapin_Pallidin X -Prkaca PKACA P05132 mouse NF-E2 18022 Q07279 Nfe2 mouse S170 450012 MEAGRRRsEYVDMYP X X -Prkaca PKACA P05132 mouse MEF2D 17261 Q63943 Mef2d mouse S121 2246700 EDKYRRAsEELDGLF HJURP_C X -Prkaca PKACA P05132 mouse NFkB-p65 5970 Q04206 RELA human S276 447798 sMQLRRPsDRELsEP RHD_dimer X -Prkaca PKACA P05132 mouse FLNA 2316 P21333 FLNA human S2152 451357 tRRRRAPsVANVGsH Filamin X 4761 -Prkaca PKACA P05132 mouse RYR2 20191 E9Q401 Ryr2 mouse S2807 448848 YNRTRRIsQtsQVsI X -Prkaca PKACA P05132 mouse QSK 70661 Q6P4S6 Sik3 mouse S551 468543 GPLGRRAsDGGANIQ X -Prkaca PKACA P05132 mouse RARA 19401 P11416 Rara mouse S369 451381 YVRKRRPsRPHMFPK Hormone_recep X X -Prkaca PKACA P05132 mouse CDK18 18557 Q04899 Cdk18 mouse S12 2192675 KNFKRRLsLSVPRPE X X -Prkaca PKACA P05132 mouse TNNI3 21954 P48787 Tnni3 mouse S23 448423 PAPVRRRssANyRAY Troponin-I_N X X -Prkaca PKACA P05132 mouse MYBPC3 17868 O70468 Mybpc3 mouse S302 471081 sLLKKRDsFRRDskL X -Prkaca PKACA P05132 mouse Doublecortin 13193 O88809 Dcx mouse S47 451112 TRTLQALsNEKKAKK X X -Prkaca PKACA P05132 mouse MARCKS 17118 P26645 Marcks mouse S156 447787 KRFsFKKsFkLsGFs MARCKS X 2741; 11992 -Prkaca PKACA P05132 mouse ADAM22 11496 Q9R1V6 Adam22 mouse S832 469108 NGRPRsNsWQGNMGG X -Prkaca PKACA P05132 mouse Vimentin 22352 P20152 Vim mouse S66 451765 GAyVtRssAVRLRss Filament_head X -Prkaca PKACA P05132 mouse HSL 3991 Q05469 LIPE human S855 448804 EPMRRsVsEAALAQP X 4137 -Prkaca PKACA P05132 mouse CDK18 18557 Q04899 Cdk18 mouse S109 468386 TRMSRRAsLsDIGFG X X -Prkaca PKACA P05132 mouse SLC29A1 63959 Q9JIM1 Slc29a1 mouse S273 21326704 sGVPGPNsPPtNRNQ Nucleoside_tran X -Prkaca PKACA P05132 mouse HPK1 26411 P70218 Map4k1 mouse S171 455474 ATLARRLsFIGTPYW Pkinase X -Prkaca PKACA P05132 mouse Vimentin 22352 P20152 Vim mouse S47 455455 LGsALRPstsRsLys Filament_head X -Prkaca PKACA P05132 mouse PPM1H 319468 Q3UYC0 Ppm1h mouse S123 479930 RNsKRRssLPNGEGL X X -Prkaca PKACA P05132 mouse SLC23A2 54338 Q9EPR4 Slc23a2 mouse S640 483980 KSENSRSsDKDsQAt X X -Prkaca PKACA P05132 mouse SHISA7 232813 Q8C3Q5 Shisa7 mouse S340 1872500600 kSELNRYsSLKRLAE X -Prkaca PKACA P05132 mouse 5-LO 240 P09917 ALOX5 human S524 452140 GMRGRKSsGFPkSVK Lipoxygenase X X -Prkaca PKACA P05132 mouse MYBPC3 295929 P56741 Mybpc3 rat S307 471081 SSLLKKSsFRRDsKL X X -Prkaca PKACA P05132 mouse PTRF 19285 O54724 Cavin1 mouse T304 2566127 DKLRksFtPDHVVyA PTRF_SDPR X -Prkaca PKACA P05132 mouse TIAM2 24001 Q6ZPF3 Tiam2 mouse S1562 19003601 VAESRRDsKSTELEK X -Prkaca PKACA P05132 mouse Merlin 18016 P46662 Nf2 mouse S518 448282 DTDMKRLsMEIEKEK ERM_C X X 9163; 13281 -Prkaca PKACA P05132 mouse GABRB1 14400 P50571 Gabrb1 mouse S409 451812 IQyRKPLssREGFGR Neur_chan_memb X -Prkaca PKACA P05132 mouse MYBPC3 17868 O70468 Mybpc3 mouse S307 2846505 RDsFRRDskLEAPAE X -Prkaca PKACA P05132 mouse JMJD3 216850 Q5NCY0 Kdm6b mouse T1044 1867766700 GGVsKVKtPTAPAPP X X -Prkaca PKACA P05132 mouse MYBPC3 17868 O70468 Mybpc3 mouse S105 17660717 APPEkAEsEVAPGAP X -Prkaca PKACA P05132 mouse IP3R1 16438 P11881 Itpr1 mouse S1755 450682 RPSGRREsLtsFGNG X 3760; 8548 -Prkaca PKACA P05132 mouse TIAM2 24001 Q6ZPF3 Tiam2 mouse T749 15503728 DSTLRKRtLsLTQRG X X -Prkaca PKACA P05132 mouse NLRP3 216799 Q8R4B8 Nlrp3 mouse S291 57761902 CKILRKPsRILFLMD NACHT X -Prkaca PKACA P05132 mouse Restin 65201 Q9JK25 Clip1 rat S311 4769833 ASLKRsPsAssLSSM X -Prkaca PKACA P05132 mouse PTRF 19285 O54724 Cavin1 mouse S169 460680 VkLPAkLsVsksLkE PTRF_SDPR X -Prkaca PKACA P05132 mouse HSL 3991 Q05469 LIPE human S950 450194 EGFHPRRssQGAtQM Abhydrolase_3 X -Prkaca PKACA P05132 mouse Merlin 18016 P46662 Nf2 mouse S10 1720901 GAIASRMsFSsLKRK X X -Prkaca PKACA P05132 mouse BAD 12015 Q61337 Bad mouse S136 447862 PFRGRsRsAPPNLWA Bcl-2_BAD X X 9295; 5286; 4366 -Prkaca PKACA P05132 mouse PHLPP2 244650 Q8BXA7 Phlpp2 mouse S1207 4754865 FGIRRQNsVNsGILL X -Prkaca PKACA P05132 mouse NMDAR2B 14812 Q01097 Grin2b mouse S1303 450171 NKLRRQHsyDtFVDL NMDAR2_C X 20274; 71335 -Prkaca PKACA P05132 mouse PIP5K1B 18719 P70181 Pip5k1b mouse S214 455789 STYKRRAsRKEREKP PIP5K X X -Prkaca PKACA P05132 mouse DARPP-32 360616 Q6J4I0 Ppp1r1b rat T34 448047 MIRRRRPtPALLFRV DARPP-32 X 12438 -Prkaca PKACA P05132 mouse Stargazin 12300 O88602 Cacng2 mouse T321 451273 NTANRRTtPV_____ X -Prkaca PKACA P05132 mouse SLC29A1 63959 Q9JIM1 Slc29a1 mouse T276 21326705 PGPNsPPtNRNQsIK Nucleoside_tran X -Prkaca PKACA P05132 mouse GLUL 14645 P15105 Glul mouse T301 15501403 LDNARRLtGFHETSN X X -Prkaca PKACA P05132 mouse SIK 59329 Q9R1U5 Sik1 rat S577 465992 FQEGRRAsDTSLTQG X -Prkaca PKACA P05132 mouse perilipin 1 25629 P43884 Plin1 rat S223 450080 PSLLRRVstLANTLS Perilipin X -Prkaca PKACA P05132 mouse SLC23A2 54338 Q9EPR4 Slc23a2 mouse S403 483979 YYACARLsCAPPPPI Xan_ur_permease X X -Prkaca PKACA P05132 mouse MYBPC3 17868 O70468 Mybpc3 mouse S273 471079 RsAFRRtsLAGAGRR X -Prkaca PKACA P05132 mouse HSP20 126393 O14558 HSPB6 human S16 450706 PSWLRRAsAPLPGLS Crystallin X 36519 -Prkaca PKACA P05132 mouse GJD2 14617 O54851 Gjd2 mouse S110 471386 KQRERRYsTVFLALD Connexin X -Prkaca PKACA P05132 mouse DUSP9 75590 Q7TNL7 Dusp9 mouse S58 22694400 LRRLRRGsMSVRSLL Rhodanese X X -Prkaca PKACA P05132 mouse CACNA1C iso5 12288 Q0PCR6 Cacna1c mouse S1700 4714250 PEIRRAIsGDLtAEE CAC1F_C X -Prkaca PKACA P05132 mouse IRE1 78943 Q9EQY0 Ern1 mouse S724 7161100 KLAVGRHsFSRRsGV Pkinase X -NUAK1 NuaK1 O60285 human p21Cip1 1026 P38936 CDKN1A human S146 447836 GRkRRQtsMTDFyHs X -NUAK1 NuaK1 O60285 human MYPT1 4659 O14974 PPP1R12A human S472 452042 AGVTRsAssPRLsss X X -NUAK1 NuaK1 O60285 human Tau iso8 4137 P10636-8 MAPT human S262 447930 NVKskIGstENLkHQ Tubulin-binding X X -NUAK1 NuaK1 O60285 human CASP6 839 P55212 CASP6 human S257 452136 TLVNRKVsQRRVDFc Peptidase_C14 X -NUAK1 NuaK1 O60285 human p53 7157 P04637 TP53 human S392 447535 FktEGPDsD______ X 9281 -NUAK1 NuaK1 O60285 human MYPT1 4659 O14974 PPP1R12A human S910 1983104 sLLGRsGsysyLEER X X -NUAK1 NuaK1 O60285 human p21Cip1 12575 P39689 Cdkn1a mouse S141 447836 GRKRRQtsLTDFYHS X -NUAK1 NuaK1 O60285 human LATS1 9113 O95835 LATS1 human S464 451855 NIPVRsNsFNNPLGN X X -NUAK1 NuaK1 O60285 human p21Cip1 12575 P39689 Cdkn1a mouse S78 14577356 GLPKVyLsPGSRSRD X -NUAK1 NuaK1 O60285 human Tau iso8 4137 P10636-8 MAPT human S356 449104 rVQskIGsLDNItHV Tubulin-binding X X -NUAK1 NuaK1 O60285 human MYPT1 4659 O14974 PPP1R12A human S445 452077 LGLRktGsyGALAEI X X -NUAK1 NuaK1 O60285 human p53 7157 P04637 TP53 human S15 447490 PsVEPPLsQEtFsDL P53_TAD X 4030; 9235; 9284; 9286; 8695; 8514; 82530; 56979 -Mark2 MARK2 Q05512 mouse CAMSAP1 227634 A2AHC3 Camsap1 mouse S1464 1869962002 PIIHNAIsHCCLAGK CAMSAP_CKK X -Mark2 MARK2 Q05512 mouse KIFAP3 16579 P70188 Kifap3 mouse S60 4711034 QKIIRLKsLNANtDI KAP X -ULK2 ULK2 Q8IYT8 human STX17 55014 P56962 STX17 human S289 4774791 MMEKLtSsCPDLPSQ X -ULK2 ULK2 Q8IYT8 human STING 340061 Q86WV6 STING1 human S366 31064700 QEPELLIsGMEkPLP X 30495; 39887; 85735; 50907; 19781; 41622; 43499; 40818; 99309; 72650 -ULK2 ULK2 Q8IYT8 human beclin 1 8678 Q14457 BECN1 human S30 7446159 QPLkLDTsFkILDRV X 54101; 35955 -ULK2 ULK2 Q8IYT8 human Raptor 57521 Q8N122 RPTOR human S792 2314600 DKMRRAssYSsLNSL X 2083; 89146 -ULK2 ULK2 Q8IYT8 human DENND3 22898 A2RUS2 DENND3 human S490 23050193 ELAPRNSsLRLtDTA X -ULK2 ULK2 Q8IYT8 human Raptor 57521 Q8N122 RPTOR human S855 3205935 QRVLDtssLtQsAPA X -ULK2 ULK2 Q8IYT8 human Raptor 57521 Q8N122 RPTOR human S859 2024885 DtssLtQsAPAsPtN X -ULK2 ULK2 Q8IYT8 human SEC16A 9919 O15027 SEC16A human S846 55578720 LAQPINFsVSLSNSH X -ULK2 ULK2 Q8IYT8 human PIK3C3 5289 Q8NEB9 PIK3C3 human S249 35483209 ESsPILTsFELVKVP X 13857 -ULK2 ULK2 Q8IYT8 human DENND3 22898 A2RUS2 DENND3 human S472 7997148 THRRMVVsMPNLQDI X diff --git a/Regulatory_sites b/Regulatory_sites deleted file mode 100644 index 20b3aff..0000000 --- a/Regulatory_sites +++ /dev/null @@ -1,20194 +0,0 @@ -GENE PROTEIN PROT_TYPE ACC_ID GENE_ID HU_CHR_LOC ORGANISM MOD_RSD SITE_GRP_ID SITE_+/-7_AA DOMAIN ON_FUNCTION ON_PROCESS ON_PROT_INTERACT ON_OTHER_INTERACT PMIDs LT_LIT MS_LIT MS_CST NOTES -AQP2 AQP2 Channel, misc.; Membrane protein, integral; Membrane protein, multi-pass; Transporter; Transporter, aquaporin family P41181 359 12q13.12 human K270-ub 999601 QSLPRGTkA______ protein degradation; intracellular localization; phosphorylation 19357255; 21209006 6 0 0 LIP5 binding to AQP2 is independent of AQP2 ubiquitination; stimulates phosphorylation of S261 -Pdpk1 PDK1 EC 2.7.11.1; KINASE; Kinase, protein; Nuclear receptor co-regulator; Protein kinase, AGC; Protein kinase, Ser/Thr (non-receptor) O55173 81745 10q12 rat Y379-p 447695 DEDCYGNyDNLLSQF enzymatic activity, induced translation, altered; cell adhesion, altered 18559349 8 1 0 Induces fibronectin expression and deposition and increases AngII mesangial cell hypertrophy -CD200R1 CD200R Membrane protein, integral; Receptor, misc. Q8TD46 131450 3q13.2 human Y325-p 458379 TEKNNPLyDTTNKVK molecular association, regulation DOK2(INDUCES) 19786546 2 2 11 recruitment of RasGAP by Dok2 -Gsk3b GSK3B EC 2.7.11.1; EC 2.7.11.26; KINASE; Kinase, protein; Protein kinase, CMGC; Protein kinase, Ser/Thr (non-receptor) P18266 84027 11q21 rat S9-p 449111 SGRPRTTsFAESCKP protein stabilization; molecular association, regulation; intracellular localization; enzymatic activity, inhibited; activity, inhibited; phosphorylation cell cycle regulation; apoptosis, altered; cell motility, induced; signaling pathway regulation; transcription, altered; autophagy, induced; cell growth, induced; apoptosis, inhibited; cytoskeletal reorganization; cell growth, altered 14-3-3 beta(INDUCES) 11018058; 11094086; 11533051; 15073173; 17200689; 19801631; 20841359; 21702924; 21736902; 22039465; 22046442; 22228770; 33518533; 33575839; 33864097; 34577062; 35216064; 8816781 570 46 227 -Sik2 QIK EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, CAMK; Protein kinase, Ser/Thr (non-receptor) Q3LRT3 315649 8q23 rat T484-p 478056 RSGQRRHtLSEVTNQ protein degradation 21220102 3 10 85 -PTEN PTEN Carbohydrate Metabolism - inositol phosphate; EC 3.1.3.16; EC 3.1.3.48; EC 3.1.3.67; Motility/polarity/chemotaxis; Nuclear receptor co-regulator; PHOSPHATASE; Phosphatase, lipid; Tumor suppressor P60484 5728 10q23.31 human S380-p 448313 EPDHYRYsDTTDSDP molecular association, regulation; protein stabilization; intracellular localization; enzymatic activity, inhibited; protein conformation; phosphorylation; enzymatic activity, altered cell cycle regulation; carcinogenesis, induced; signaling pathway regulation; transcription, altered; neural plasticity; cell differentiation, altered; chromatin organization, altered; cell motility, altered; apoptosis, inhibited PTEN(INDUCES); PTEN(DISRUPTS) DNA(INDUCES) 10866658; 11035045; 12077256; 17240336; 17565999; 22413754; 24706748; 24766807; 25823029; 33760042; 35884549; 36155262 40 0 0 regulates CHK1 phosphorylation and activation and H2AX phosphorylation -Psma2 PSMA2 EC 3.4.25.1; Protease; Proteasome complex P17220 29669 17q12.1 rat Y121-p 450235 VASVMQEyTQSGGVR Proteasome intracellular localization 8794741 1 0 0 -DDX5 DDX5 EC 3.6.4.13; Helicase; Nuclear receptor co-regulator; Nucleolus; RNA splicing; RNA-binding; Spliceosome P17844 1655 17q23.3 human T69-p 1875793000 HPDLARRtAQEVETY sumoylation; protein stabilization; molecular association, regulation; ubiquitination carcinogenesis, induced; cell motility, induced; cell growth, induced PIAS1(INDUCES); DROSHA(INDUCES); DGCR8(INDUCES) 34936874 1 0 0 inhibits ubiquitination -MAPT Tau iso8 ACETYLTRANSFERASE; Acetyltransferase; Cytoskeletal P10636-8 4137 17q21.31 human T231-p 449079 KKVAVVRtPPKSPSS molecular association, regulation; protein processing; intracellular localization; protein conformation; phosphorylation apoptosis, altered; cell growth, inhibited; autophagy, inhibited; cytoskeletal reorganization; signaling pathway regulation TUBA4A(DISRUPTS); Fyn(DISRUPTS); Tau iso8(INDUCES); TUBA1A(INDUCES); PIN1(INDUCES); BIN1(DISRUPTS) 12414518; 15190058; 15542598; 16024016; 16115884; 16687396; 17045592; 20375017; 20550628; 20663882; 21731772; 25573097; 29298849; 31065832; 33710538; 33967735 149 48 14 -DICER1 DICER1 Cell development/differentiation; EC 3.1.26.3; Helicase; RNA processing; RNA-binding; Ribonuclease Q9UPY3 23405 14q32.13 human S1016-p 3216312 GKALPLSsAEKRKAK PAZ intracellular localization carcinogenesis, induced; DNA repair, induced; cell growth, induced; RNA stability, altered 28642363; 35995401 2 8 0 -DNMT1 DNMT1 Amino Acid Metabolism - cysteine and methionine; Cell development/differentiation; EC 2.1.1.37; METHYLTRANSFERASE; Methyltransferase; Methyltransferase, DNA; Transcription regulation P26358 1786 19p13.2 human K961-ac 25171006 SPVKRPRkEPVDEDL BAH cell cycle regulation 21947282 1 1 0 -BUB3 BUB3 Cell cycle regulation O43684 9184 10q26.13 human S19-p 15180600 PPEDGISsVKFSPNT WD40 apoptosis, induced 20057499 1 1 0 caspase-independent mitotic death (CIMD) -EIF2S1 eIF2-alpha RNA-binding; Translation; Translation initiation P05198 1965 14q23.3 human K141-ac 11324636 TAWVFDDkYKRPGYG EIF_2_alpha apoptosis, induced 27911441 1 5 0 -BUD13 BUD13 RNA splicing; Spliceosome Q9BRD0 84811 11q23.3 human T159-p 470734 PRRARHDtPDPSPLR molecular association, regulation carcinogenesis, induced; cell growth, induced FBXW7(DISRUPTS) 37382881 1 56 44 -MRE11 MRE11A Cell cycle regulation; DNA repair, damage; DNA-binding; Deoxyribonuclease P49959 4361 11q21 human S382-p 11506403 PFSVLRFsQKFVDRV Mre11_DNA_bind molecular association, regulation DNA(DISRUPTS) 19709933 1 0 0 -CLASP2 CLASP2 Cytoskeletal; Motility/polarity/chemotaxis O75122 23122 3p22.3 human S1092-p 27434506 MKLTQEEsFSVWDEH cell cycle regulation 23045552 1 1 0 -Syk Syk EC 2.7.10.2; KINASE; Kinase, protein; Protein kinase, TK; Protein kinase, tyrosine (non-receptor) P48025 20963 13 A5|13 27.41 cM mouse Y317-p 447658 STVSFNPyEPTGGPW molecular association, regulation; enzymatic activity, inhibited; protein conformation; phosphorylation endocytosis, altered; transcription, altered; signaling pathway regulation CBL(INDUCES); PIK3R1(INDUCES) 12077122; 15536084; 15576379; 9820500 21 30 1019 -E2F1 E2F1 DNA-binding; Transcription factor Q01094 1869 20q11.22 human K120-ac 459018 RHPGKGVkSPGEKSR protein stabilization; molecular association, regulation apoptosis, induced; transcription, induced DNA(INDUCES) 10675335; 10753885; 22184068 3 0 0 etoposide-induced DNA damage, pRB-free form of E2F1, does not bind to pRB; both complexes act in parallel to induce transcription of proapoptotic genes -BRIP1 BRIP1 EC 3.6.4.13; Helicase; Oncoprotein Q9BX63 83990 17q23.2 human K1249-ac 15293613 KGMFPGFk_______ DNA repair, induced 22792074 1 1 1 FANCJ K1249R or BRIP1 K1249Q promotes pol H- or Rad54-dependent repair, respectively; promotes resection-associated events; promote an RPA response -FOXO4 FOXO4 DNA-binding; Oncoprotein; Transcription factor P98177 4303 Xq13.1 human S268-p 231166708 SSNASSVsTRLSPLR protein degradation; phosphorylation 28945225 1 0 0 26 S proteasome-mediated FOXO4 proteolysis in the nuclei of RAS mutant colon cancer cells -Cabp4 CABP4 Calcium-binding Q8VHC5 73660 19|19 A mouse S37-p 1315600 PALTRRRsKKESWHP activity, induced; molecular association, regulation CACNA1F(INDUCES) 18003854; 23341017 2 1 0 Ca2+ v1.3 channel activity induced; Ca(2+) current kinetics -NCOA3 SRC-3 ACETYLTRANSFERASE; Acetyltransferase; EC 2.3.1.48; Motility/polarity/chemotaxis; Nuclear receptor co-regulator; Transcription, coactivator/corepressor Q9Y6Q9 8202 20q13.12 human S857-p 453084 PPYNRAVsLDSPVSV molecular association, regulation carcinogenesis, induced; cell growth, induced; cell motility, induced; transcription, induced ER-alpha(DISRUPTS); ETV4(INDUCES) 15383283; 22505454; 23850489; 33542078; 36476868 11 48 5 -GNA11 G-alpha 11 G protein; G protein, heterotrimeric; G protein, heterotrimeric alpha G(q) P29992 2767 19p13.3 human S154-p 471084 RRREYQLsDSAKYYL G-alpha molecular association, regulation; receptor desensitization, altered 5-HT(2A)(DISRUPTS) 17056873; 17646429 2 0 0 -Il1rl1 IL1RL1 Membrane protein, integral; Receptor, cytokine P14719 17082 1 B|1 19.19 cM mouse K326-ub 25585003 HTIRLRRkQPIDHRS protein degradation apoptosis, inhibited 22660580 1 0 0 -POLE POLE DNA repair, damage; DNA replication; EC 2.7.7.7; Nucleotide Metabolism - purine; Nucleotide Metabolism - pyrimidine; Transferase Q07864 5426 12q24.33 human S1940-p 481837 IHCGLQDsQKAGGAE molecular association, regulation MMS19(INDUCES) 27235625 1 8 24 -CDC25C CDC25C EC 3.1.3.48; Motility/polarity/chemotaxis; PHOSPHATASE; Protein phosphatase, dual-specificity P30307 995 5q31.2 human S75-p 125104500 PKRCLDLsNLSSGEI cell cycle regulation 28591578 1 1 0 -ECE1 ECE1 iso3 Cell surface; EC 3.4.24.71; Membrane protein, integral; Protease; Vesicle P42892-3 1889 1p36.12 human S20-p 3053606 EDLVDSLsEGDAYPN protein stabilization; intracellular localization; phosphorylation cell cycle regulation; carcinogenesis, induced; cell growth, induced; cell motility, induced; apoptosis, inhibited; transcription, induced 26543229; 32850305 3 11 0 induces FAK phosphorylation; colon cancer cell invasion. -DCX Doublecortin Cytoskeletal; Motility/polarity/chemotaxis O43602 1641 Xq23 human S297-p 451111 PQKTSAKsPGPMRRS molecular association, regulation cytoskeletal reorganization TUBA1B(DISRUPTS); ACTA1(INDUCES) 15632197 8 1 4 -CD5 CD5 Cell surface; Membrane protein, integral P06127 921 11q12.2 human Y453-p 447774 ASHVDNEySQPPRNS activity, induced 11751967 6 10 292 phosphorylation of Y453 is essential for CD5 functions, including inhibition of the BCR-induced calcium response, inhibition of Akt translocation, inhibition of IL-2 production. -CHRM2 mAChR M2 GPCR, family 1; Membrane protein, integral; Membrane protein, multi-pass; Receptor, GPCR P08172 1129 7q33 human T423-p 487430 CIPNTVWtIGYWLCY 7tm_1 molecular association, regulation 17525129 1 0 0 -MFN2 MFN2 Cell cycle regulation; Cytoskeletal; EC 3.6.5.-; Hydrolase; Membrane protein, integral; Membrane protein, multi-pass; Mitochondrial O95140 9927 1p36.22 human S27-p 25594503 HMAEVNAsPLKHFVT protein degradation; ubiquitination apoptosis, induced HUWE1(INDUCES) 22748923 2 3 0 HUWE1 associates with Mfn2, and leads to Its ubiquitination and degradation. -PACS2 PACS2 Q86VP3 23241 14q32.33 human S207-p 1884003500 EEEYESFsSEQEASD intracellular localization 37523531 1 0 0 -KCNMA1 KCNMA1 Channel, potassium; Endoplasmic reticulum; Membrane protein, integral; Membrane protein, multi-pass Q12791 3778 10q22.3 human S992-p 469989 HGMLRQPsITTGVNI activity, induced 11078709 4 2 0 -Hcn1 HCN1 Membrane protein, integral; Membrane protein, multi-pass Q9JKB0 rat S791-p 1872043505 PKNEVHKsTQALHNT activity, inhibited 33571596 1 1 0 -Pycard PYCARD Adaptor/scaffold; Tumor suppressor Q9EPB4 66824 7|7 F3 mouse K55-ub 1881518205 DAIDLTDkLVSYYLE molecular association, regulation NLRP3(INDUCES); PYCARD(INDUCES) 34706239 1 0 0 PYCARD oigomerization, NLRP3 infammasome activation -CCNA2 CCNA2 Cell cycle regulation; Nuclear receptor co-regulator P20248 890 4q27 human K68-ac 7761213 LAQQQRPkTRRVAPL Cyclin_N2 protein degradation; molecular association, regulation cell cycle regulation CDK2(DISRUPTS) 19483727; 23760262 2 1 0 -ACTL6A BAF53A O96019 86 3q26.33 human S233-p 471130 KEAVREGsPANWKRK Actin molecular association, regulation apoptosis, induced; transcription, induced RASSF6(INDUCES) 34898277 1 37 10 -HDAC3 HDAC3 Apoptosis; Cell cycle regulation; DEACETYLASE; Deacetylase; EC 3.5.1.98; Nuclear receptor co-regulator; Transcription, coactivator/corepressor O15379 8841 5q31.3 human Y331-p 15228119 PYSEYFEyFAPDFTL activity, induced; intracellular localization; enzymatic activity, induced carcinogenesis, induced; cell growth, induced 30317579; 31430896 2 0 1 -CROCC CROCC iso2 Cytoskeletal Q5TZA2-2 9696 1p36.13 human S922-p 481961 TESELRAsQEKISKM protein stabilization; phosphorylation carcinogenesis, inhibited; cell growth, inhibited; transcription, induced 24240686 1 3 0 p38 phosphorylation; suppress ubiquitination/protein degradation -TBX21 TBX21 DNA-binding; Transcription factor Q9UL17 30009 17q21.32 human Y305-p 20583305 QFIAVTAyQNAEITQ T-box molecular association, regulation cell differentiation, altered; cell growth, induced; transcription, induced DNA(INDUCES) 21690296 1 0 0 -Ryr2 RYR2 Channel, ligand-gated; Membrane protein, integral; Membrane protein, multi-pass; Transporter; Transporter, ion channel E9Q401 20191 13 A1|13 4.38 cM mouse S2030-p 455603 TIRGRLLsLVEKVTY activity, induced; protein conformation; phosphorylation 17693412; 17967164; 30541771 14 4 1 inhibits phosphorylation at S2807 and S2813, increases calcium sensitivity -Rit1 RIT1 G protein; G protein, monomeric; G protein, monomeric, Ras P70426 19769 3|3 F1 mouse K135-ub 12382090 PVVLVGNkSDLKQLR Ras protein degradation; ubiquitination 30872527 1 3 2 ubiquitination occured only when TUBEs and LZTR1 were coexpressed, when RIT1 oncogenic mutations are present ubiquitination was decreased -ADD2 ADD2 Cytoskeletal; Motility/polarity/chemotaxis P35612 119 2p13.3 human S697-p 467408 GPMSPEGsPSKSPSK cell growth, induced; cytoskeletal reorganization 21606488 1 13 0 -LEPR LEPR Membrane protein, integral; Receptor, cytokine P48357 3953 1p31.3 human K879-ub 1872271904 WEDVPNPkNCSWAQG receptor internalization, induced endocytosis, induced 16482222 1 0 0 -MAD1L1 MAD1L1 Cell cycle regulation; Cytoskeletal Q9Y6D9 8379 7p22.3 human T680-p 5024706 SKMQLLEtEFSHTVG MAD activity, induced; intracellular localization cell cycle regulation 18922800 1 1 0 -TRPV1 TRPV1 Channel, cation; Membrane protein, integral; Membrane protein, multi-pass; Receptor, misc. Q8NER1 7442 17p13.2 human Y200-p 458384 ASYTDSYyKGQTALH Ank_2 receptor desensitization, altered; intracellular localization 16319926 2 0 0 -ATG13 ATG13 Autophagy; Vesicle O75143 9776 11p11.2 human T342-p 1869357206 DRTHCAAtPSSSEDT cell cycle regulation; autophagy, induced; cell growth, induced 32516310 1 1 0 -Map3k8 Cot EC 2.7.11.25; KINASE; Kinase, protein; Oncoprotein; Protein kinase, STE; Protein kinase, Ser/Thr (non-receptor) Q07174 26410 18 A1|18 2.73 cM mouse S400-p 447712 EDQPRCQsLDSALFE activity, induced; molecular association, regulation; phosphorylation signaling pathway regulation ERK2(INDUCES); 14-3-3 gamma(INDUCES) 17709378; 24912162 4 2 0 induces Cot signaling -Cd22 CD22 Cell surface; Membrane protein, integral P35329 12483 7 B1|7 19.26 cM mouse Y863-p 450944 QAKEDVDyVTLKH__ molecular association, regulation; activity, inhibited; phosphorylation Syk(INDUCES); PLCG1(INDUCES); SHP-1(INDUCES); PIK3R1(INDUCES) 10373493; 11551923; 18024433; 27276708 6 0 12 negatively regulate calcium signal -ITPR1 IP3R1 Channel, calcium; Channel, ligand-gated; Membrane protein, integral; Membrane protein, multi-pass Q14643 3708 3p26.1 human T800-p 450269 RDPQEQVtPVKYARL molecular association, regulation exocytosis, induced Other(INDUCES) 16237118 4 0 0 enhances IP3 binding to IP3R1, and calcium release -Pdgfrb PDGFRB EC 2.7.10.1; KINASE; Kinase, protein; Membrane protein, integral; Oncoprotein; Protein kinase, TK; Protein kinase, tyrosine (receptor) P05622 18596 18 E1|18 34.41 cM mouse Y580-p 447519 SDGHEYIyVDPVQLP molecular association, regulation PLCG1(INDUCES) 11281646 6 1 0 -Bckdha BCKDH E1-alpha Amino Acid Metabolism - valine, leucine and isoleucine degradation; EC 1.2.4.4; Lyase; Mitochondrial; Oxidoreductase P11960 25244 1q21 rat S333-p 449636 TYRIGHHsTSDDSSA E1_dh enzymatic activity, inhibited cell growth, induced 27472223; 3947057 10 60 24 inhibited catabolism of the branched-chain amino acids, decrease phosphorylation frogleg phenotype -Cdh1 CDH1 Cell adhesion; Membrane protein, integral; Motility/polarity/chemotaxis; UBIQUITIN LIGASE; Ubiquitin ligase P09803 12550 8 D3|8 53.18 cM mouse S840-p 465565 LVFDYEGsGSEAASL CADH_Y-type_LIR molecular association, regulation CTNNB1(INDUCES) 11348595 5 1 0 -VCP VCP Chaperone; DNA repair, damage; EC 3.6.4.6; Endoplasmic reticulum; Hydrolase P55072 7415 9p13.3 human T76-p 1876872800 CIVLSDDtCSDEKIR CDC48_N intracellular localization; protein conformation cell cycle regulation; carcinogenesis, induced; apoptosis, inhibited; cytoskeletal reorganization; transcription, altered 35430615 1 0 0 -MDC1 MDC1 Cell cycle regulation Q14676 9656 6p21.33 human S20-p 63083900 EEEETEQsSESLRCN intracellular localization cell cycle regulation 28193847 1 0 0 maintenance of chrosome stabiliy -SLC6A3 DAT Membrane protein, integral; Membrane protein, multi-pass; Transporter; Transporter, SLC family Q01959 6531 5p15.33 human T613-p 451142 RGEVRQFtLRHWLKV signaling pathway regulation 22514303 2 0 0 -H2ac4 H2A.1 DNA-binding C0HKE1 319172 13|13 A3.1 mouse K118-ub 3945247 IQAVLLPkKTESHHK Histone_H2A_C molecular association, regulation; ubiquitination cell cycle regulation; cell growth, induced; transcription, altered; transcription, inhibited FBXL10(INDUCES) DNA(INDUCES) 23256043; 23395003; 24025767; 24070375 12 14 157 -HIF1A HIF1A Autophagy; DNA-binding; Transcription factor Q16665 3091 14q23.2 human K10-ac 25126718 GAGGANDkKKISSER protein degradation transcription, inhibited 21917920; 28319066 2 0 0 -H3C1 H3 DNA-binding P68431 8350 6p22.2 human K27-m2 1308912 LATKAARkSAPATGG Histone carcinogenesis, induced; cell differentiation, induced; chromatin organization, altered; transcription, induced; transcription, inhibited 18628788; 20132554; 20864036; 31015297 42 21 7 -IL2RB IL2RB Membrane protein, integral; Receptor, cytokine P14784 3560 22q12.3 human Y418-p 450884 LSGEDDAyCTFPSRD molecular association, regulation apoptosis, inhibited; cell growth, altered SHB(INDUCES) 12200137 3 0 0 -IRF3 IRF3 DNA-binding; Transcription factor Q14653 3661 19q13.33 human T135-p 477901 GGGSTSDtQEDILDE protein stabilization; intracellular localization 11867762 2 24 7 -EEF2 EEF2 Translation; Translation elongation P13639 1938 19p13.3 human K594-m1 58123400 SNVLCLSkSPNKHNR molecular association, regulation L3MBTL iso4(INDUCES) 23583077 0 1 0 -YAP1 YAP1 Oncoprotein; Transcription, coactivator/corepressor P46937 10413 11q22.1 human S367-p 471290 GTQNPVSsPGMSQEL molecular association, regulation; intracellular localization cell cycle regulation; carcinogenesis, induced; cell motility, induced; apoptosis, inhibited; cytoskeletal reorganization TEAD4(DISRUPTS) 24101154; 24812269; 26933062 8 29 12 mitotic shift, important for proper mitosis and cytokinesis -PHB1 PHB Apoptosis; Cell cycle regulation; Chaperone; Mitochondrial; Motility/polarity/chemotaxis; Nuclear receptor co-regulator; Oncoprotein; Transcription, coactivator/corepressor P35232 5245 17q21.33 human T258-p 11139253 LSRSRNItYLPAGQS protein stabilization; molecular association, regulation; intracellular localization; phosphorylation carcinogenesis, induced; cell growth, induced; cell motility, induced; apoptosis, inhibited; transcription, inhibited; signaling pathway regulation ER-alpha(DISRUPTS); RAF1(INDUCES) DNA(DISRUPTS) 22410782; 25575814; 25719244; 32665357 6 0 1 induces ERK phosphorylation and modulates Ras phosphorylation; dephosphorylation induces binding to Axin1 promoter thus inhibiting Wnt/beta-catenin signaling through degradation of beta-catenin; PIP3 induced migration/invasion, colonization/ metastasis ; mitochondrial localization -NCOA3 SRC-3 ACETYLTRANSFERASE; Acetyltransferase; EC 2.3.1.48; Motility/polarity/chemotaxis; Nuclear receptor co-regulator; Transcription, coactivator/corepressor Q9Y6Q9 8202 20q13.12 human S102-p 4661900 VQKADVSsTGQGVID protein degradation; molecular association, regulation carcinogenesis, inhibited; cell growth, altered SPOP(INDUCES) 18922467; 21577200 2 0 0 -ATM ATM DNA repair, damage; EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, Ser/Thr (non-receptor); Protein kinase, atypical; Tumor suppressor Q13315 472 11q22.3 human T373-p 481860 ISQSYTTtQRESSDY enzymatic activity, inhibited; protein conformation cell cycle regulation; apoptosis, inhibited 27939942 1 1 0 -EGFR EGFR EC 2.7.10.1; KINASE; Kinase, protein; Membrane protein, integral; Oncoprotein; Protein kinase, TK; Protein kinase, tyrosine (receptor) P00533 1956 7p11.2 human K860-ub 1065315 ITDFGLAkLLGAEEK PK_Tyr_Ser-Thr protein degradation 17940017 1 6 1 -Polr2a POLR2A EC 2.7.7.48; EC 2.7.7.6; Nucleotide Metabolism - purine; Nucleotide Metabolism - pyrimidine; Transcription initiation complex; Transferase P08775 20020 11 B3|11 42.86 cM mouse S1616-p 450204 TPQSPSYsPTSPSYS RNA_pol_Rpb1_R molecular association, regulation; intracellular localization; enzymatic activity, inhibited; phosphorylation; enzymatic activity, induced RNA splicing, induced; transcription, induced; transcription, altered SETD1B(INDUCES); SETD2(INDUCES); U2AF2(INDUCES); SETD1A(INDUCES) 17535807; 21385826; 21639898; 27322654; 28423325; 28768201 81 4 0 recruitment of CDK9 to the Cxcl1 locus, repressed by Hes1 ; elongation, splicing optimization correlates with increasing S1616 phosphorylatio; deletion of MNAT reduces S1619 phosphorylation and defective capping and reduced S1616 phosphorylation and defect in Pol II transcription -Nr4a1 Nur77 Apoptosis; DNA-binding; Nuclear receptor P22829 79240 7q36 rat S350-p 447942 GRRGRLPsKPKQPPD molecular association, regulation apoptosis, inhibited 14-3-3 beta(INDUCES) DNA(INDUCES) 11438550; 16835233 11 4 0 -Aicda AID EC 3.5.4.38; Hydrolase Q9WVE0 11628 6|6 F1 mouse T27-p 471423 WAKGRHEtYLCYVVK APOBEC2 molecular association, regulation; enzymatic activity, induced chromatin organization, altered RPA1(INDUCES) 16251902; 17911613 5 2 0 promotes deamination of transcribed dsDNA substrates in B cells; Mutation of either site significantly decreases gene conversion (GCV) & somatic hypermutation (SHM) frequency. -PLCG1 PLCG1 Carbohydrate Metabolism - inositol phosphate; EC 3.1.4.11; Motility/polarity/chemotaxis; Phospholipase P19174 5335 20q12 human Y1253-p 448576 EGSFESRyQQPFEDF intracellular localization 22847294 12 19 85 nuclear localization -DVL2 DVL2 Adaptor/scaffold; Motility/polarity/chemotaxis O14641 1856 17p13.1 human Y18-p 12170303 VGETKVIyHLDEEET DIX transcription, induced 19920076 1 1 0 regulates Wnt3a/beta-catenin signaling -Agtr1a AT1 GPCR, family 1; Membrane protein, integral; Membrane protein, multi-pass; Receptor, GPCR P29754 11607 13 A3.2|13 13.19 cM mouse Y319-p 448745 YFLQLLKyIPPKAKS activity, induced 16902180 5 0 0 Transgenic mice with cardiac-specific overexpression of Y319F mutant AT1 have reduced EGFR activation, and do not develop cardiac hypertrophy, fibrosis or apoptosis -Lpp LPP Adaptor/scaffold; Cytoskeletal; Motility/polarity/chemotaxis Q8BFW7 210126 16|16 B1 mouse Y318-p 448947 RSEGDTAyGQQVQPN cell cycle regulation; cell motility, altered 18515860 1 16 256 -WDR62 WDR62 Adaptor/scaffold O43379 284403 19q13.12 human T1053-p 460021 PSSSLPQtPEQEKFL activity, induced; protein degradation; molecular association, regulation; ubiquitination; intracellular localization; protein conformation cell cycle regulation; cytoskeletal reorganization FBXW7(INDUCES) 25501809; 30566428; 34137789 3 10 21 -FOXO1 FOXO1A DNA-binding; Nuclear receptor co-regulator; Oncoprotein; Transcription factor Q12778 2308 13q14.11 human S212-p 4258803 SSAGWKNsIRHNLSL Forkhead molecular association, regulation DNA(DISRUPTS) 18786403 3 1 0 -TCF3 E2A Cell development/differentiation; DNA-binding; Oncoprotein; Transcription factor P15923 6929 19p13.3 human S379-p 3180968 AGAPGALsPSYDGGL activity, inhibited transcription, inhibited 19801649 1 35 15 -Acin1 acinus Apoptosis; RNA splicing; RNA-binding; Spliceosome E9PST5 305884 15p13 rat S1180-p 456759 GPRSRSRsRDRRRKE RSB_motif protein stabilization 16177823 4 2 0 S1180 phosphorylation prevents proteolytic degradation of acinus and blocks chromatin condensation in vivo and in vitro -DEPTOR DEPTOR Apoptosis Q8TB45 64798 8q24.12 human S244-p 4723808 SSQETHDsPFCLRKQ protein degradation; molecular association, regulation carcinogenesis, induced; apoptosis, inhibited; signaling pathway regulation mTOR(DISRUPTS) 19446321 2 17 9 PI3K-Akt signaling -REST REST C2H2-type zinc finger protein; Cell development/differentiation; DNA-binding; Transcription factor Q13127 5978 4q12 human S861-p 36320700 SVSTEDLsPPSPPLP protein degradation; molecular association, regulation; protein conformation cell differentiation, inhibited; transcription, induced BTRC(INDUCES); RCOR1(DISRUPTS); PIN1(INDUCES) 25197063; 30217818 2 2 0 -Sik2 QIK EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, CAMK; Protein kinase, Ser/Thr (non-receptor) Q8CFH6 235344 9|9 A5.3 mouse S358-p 487501 DGRQRRPsTIAEQTV enzymatic activity, induced 17805301 5 9 134 -SP1 SP1 C2H2-type zinc finger protein; DNA-binding; Transcription factor P08047 6667 12q13.13 human S612-gl 5262505 TCPYCKDsEGRGSGD transcription, induced 18513490 2 1 0 -Ripk1 RIPK1 EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, Ser/Thr (non-receptor); Protein kinase, TKL Q60855 19766 13 A3.3|13 14.01 cM mouse S25-p 27116402 LEKTDLDsGGFGKVS PK_Tyr_Ser-Thr enzymatic activity, inhibited; phosphorylation 36707047 3 4 0 inhibits phosphorylation of itself at S166 -TRADD TRADD Adaptor/scaffold; Apoptosis Q15628 8717 16q22.1 human S296-p 20831308 LEENELTsLAEDLLG Death molecular association, regulation transcription, induced FADD(INDUCES); TNF-R1(INDUCES); RIP(INDUCES) 21724995 1 0 0 -ELF4 ELF4 DNA-binding; Oncoprotein; Transcription factor Q99607 2000 Xq26.1 human T643-p 463813 SLLTRSPtPAPFSPF protein degradation 16581786; 25081543 2 6 2 -Blnk BLNK Adaptor/scaffold Q9QUN3 17060 19 C3|19 34.26 cM mouse K42-ub 23303202 KIKKLKVkGPPSVPR molecular association, regulation; ubiquitination 14-3-3 beta(INDUCES) 22334673 1 0 0 Thr-152 phosphorylation induces BLNK ubiquitination at K37, K38, K42. -Nfatc2 NFAT1 DNA-binding; Transcription factor Q60591 18019 2 H3|2 88.91 cM mouse K897-sm 12057402 LPTGVTVkQEQNLDQ intracellular localization transcription, induced 15117942 1 1 0 -APOBEC3G APOBEC3G EC 3.5.4.-; Hydrolase; RNA processing; RNA-binding Q9HC16 60489 22q13.1 human K297-ub 11956702 SCAQEMAkFISKNKH NAD2 protein degradation 19887642 1 0 0 -RAPH1 RAPH1 Adaptor/scaffold; Motility/polarity/chemotaxis Q70E73 65059 2q33.2 human Y426-p 465028 LLRASGIyYVPKGKA PH molecular association, regulation cell motility, induced 26996666 2 1 14 Lpd-Scar/WAVE interaction is positively regulated by c-Abl and c-Src, breast cancer cell invasion -CYCS CYCS Apoptosis; Mitochondrial; Oxidoreductase; PHOSPHATASE; Protein phosphatase, Ser/Thr (non-receptor) P00004 100053958 horse K73-ac 479678 MEYLENPkKYIPGTK Cytochrom_C enzymatic activity, induced 19645667 1 5 83 -NKAP NKAP Unknown function Q8N5F7 79576 Xq24 human Y352-p 34731681 ASFECSGyVMSGSRH Nkap_C molecular association, regulation apoptosis, inhibited HDAC3(INDUCES) 30804042 1 0 2 regulates hematopoietic stem cell maintenance and survival -TTK TTK Cancer Testis Antigen (CTA); EC 2.7.12.1; KINASE; Kinase, protein; Protein kinase, Other; Protein kinase, dual-specificity (non-receptor) P33981 7272 6q14.1 human T46-p 41389704 NKISADTtDNSGTVN intracellular localization; enzymatic activity, induced 26119734; 36395767 2 1 0 -KIF18A KIF18A Microtubule-binding; Motor Q8NI77 81930 11p14.1 human S684-p 3207072 KGQHTLKsPPSQSVQ molecular association, regulation; enzymatic activity, inhibited cell cycle regulation PPP2R2C(DISRUPTS); PPP2R3B(INDUCES); PPP2R5C(DISRUPTS); PPP2R3A(INDUCES) 32900880 0 8 0 -Pard3 PAR3-alpha Adaptor/scaffold; Motility/polarity/chemotaxis Q9Z340 81918 19q12 rat S852-p 1983958 VKTRKSKsMDLGIAD intracellular localization cytoskeletal reorganization 33093242 1 42 0 regulation of PAR3 oligomerization, regulation of tight junction formations and morphological changes in epithelial cell layer -Cacng2 Stargazin Channel, calcium; Membrane protein, integral; Membrane protein, multi-pass Q71RJ2 84347 7q34 rat S237-p 455314 RYRYQRRsRSSSRST molecular association, regulation neural plasticity PSD-95(INDUCES) 25843401 3 0 0 -PDE6G PDE6G EC 3.1.4.35; Nucleotide Metabolism - purine; Phosphodiesterase P04972 281977 cow T22-p 449334 RVMGGPVtPRKGPPK PDE6_gamma phosphorylation 19878658 5 1 5 mutation of this site attenuates basal PDE6G phosphorylation at T35 -NCAM1 NCAM1 iso1 Cell adhesion; Membrane protein, GPI anchor; Membrane protein, integral; Motility/polarity/chemotaxis P13591-1 4684 11q23.2 human S774-p 456432 AAFSKDEsKEPIVEV phosphorylation cell growth, induced 22419107 2 32 2 CREB phosphorylation and activation -RELA NFkB-p65 DNA-binding; Nuclear receptor co-regulator; Transcription factor Q04206 5970 11q13.1 human K315-m1 7493901 TFKSIMKkSPFSGPT protein degradation transcription, inhibited 19262565 2 1 0 -JUN Jun Oncoprotein; Transcription factor P05412 3725 1p32.1 human S249-p 455367 LSPIDMEsQERIKAE molecular association, regulation; activity, inhibited carcinogenesis, induced; cell growth, induced; apoptosis, inhibited; transcription, altered SP1(DISRUPTS) 1516134; 17215518; 34936696 4 1 1 -SMN1 SMN RNA processing; RNA-binding Q16637 6606 5q13.2 human S18-p 12668173 GVPEQEDsVLFRRGT molecular association, regulation; intracellular localization coilin(INDUCES) 24602413 1 4 0 -Stx16 STX16 Membrane protein, integral; Vesicle Q8BVI5 228960 2|2 H4 mouse T7-p 4754210 _MATRRLtDAFLLLR molecular association, regulation; intracellular localization VPS45A(DISRUPTS) 37520260 1 2 12 regulates GLUT4 localization -NUMB NUMB iso3 Cell development/differentiation P49757-3 8650 14q24.2-q24.3 human S7-p 487518 _MNKLRQsFRRKKDV molecular association, regulation; intracellular localization endocytosis, inhibited AP2A1(DISRUPTS); CDH1(DISRUPTS); CTNND1(DISRUPTS) 21775625 2 3 1 -Mapt Tau ACETYLTRANSFERASE; Acetyltransferase; Cytoskeletal P10637 17762 11 67.79 cM|11 E1 mouse S701-p 449132 DTSPRHLsNVSSTGS molecular association, regulation AKAP5(INDUCES); PKAR2B(INDUCES); PKACB(INDUCES) 10460255 13 10 5 -Cux1 CUTL1 DNA-binding; Membrane protein, integral; Transcription factor P53564 13047 5 G2|5 75.96 cM mouse S1170-p 487431 PKPWHKLsLKGREPF CUT transcription, inhibited 17682059 1 0 0 inhibits FIH-1 expression -YBX3 CSDA RNA-binding; Transcription factor P16989 8531 12p13.2 human S134-p 3181076 NPRKYLRsVGDGETV CSD cell growth, induced 21368869 1 30 1 -SP1 SP1 C2H2-type zinc finger protein; DNA-binding; Transcription factor P08047 6667 12q13.13 human T737-p 36897200 AGSEGSGtATPSALI protein stabilization; molecular association, regulation; intracellular localization cell cycle regulation RNF4(DISRUPTS) DNA(DISRUPTS) 25398907 1 0 0 -Oprd1 DOR-1 GPCR, family 1; Membrane protein, integral; Membrane protein, multi-pass; Receptor, GPCR P32300 18386 4 D2.3|4 64.78 cM mouse S363-p 448550 RVTACTPsDGPGGGA receptor internalization, induced; receptor desensitization, induced; receptor desensitization, altered; intracellular localization; receptor internalization, altered 10973976; 19014372; 21220103 12 1 0 -CTTN Cortactin Actin-binding; Cytoskeletal; Motility/polarity/chemotaxis Q14247 2017 11q13.3 human K87-ac 466100 ASHGYGGkFGVEQDR HS1_rep molecular association, regulation; intracellular localization cell motility, inhibited ACTB(DISRUPTS) 17643370 1 4 13 Acetylation prevents localization to membrane ruf?es. -NRF1 NRF1 DNA-binding; Transcription factor Q16656 4899 7q32.2 human S102-p 1868914505 HVFESNPsIRKRQQT Nrf1_DNA-bind molecular association, regulation cell cycle regulation; transcription, altered DNA(DISRUPTS) 31350280 1 1 0 meiotic regulation -TOP1 TOP1 EC 5.99.1.2; Isomerase; Nucleolus; Oncoprotein P11387 7150 20q12 human K391-sm 40724402 INCSKDAkVPSPPPG Topoisom_I_N molecular association, regulation; enzymatic activity, inhibited POLR2A(INDUCES) 25851487 1 0 0 recruitment of mRNA processing factors to transcriptionally active chromatin preventing R-loops -FUS hnRNP P2 DNA-binding; Nuclear receptor co-regulator; Oncoprotein; RNA splicing; RNA-binding; SUMO LIGASE P35637 2521 16p11.2 human S42-p 3306333 QQSYSGYsQSTDTSG molecular association, regulation; protein conformation 28942918; 29610493 6 2 0 strongly reduced the effects of DNA-PK treatment on both hydrogel binding and droplet formation; precise steric regulation of the rolled-sheet amyloid fibril architecture formed by hnRNP P2 RAC1 and its potential contribution to the assembly of hnRNP P2 in RNA granules -PGR PR DNA-binding; Nuclear receptor; Transcription factor P06401 5241 11q22.1 human K183-ac 30332700 SGTAAAHkVLPRGLS Prog_receptor molecular association, regulation; phosphorylation transcription, induced DNA(INDUCES) 24302725 1 1 0 FKBP5 transcription; associated with increased S294 phosphorylation -MDM2 MDM2 EC 6.3.2.-; EC 6.3.2.19; Inhibitor; Ligase; NEDDYLATION LIGASE; Neddylation Ligase; Nucleolus; Oncoprotein; UBIQUITIN LIGASE; Ubiquitin conjugating system; Ubiquitin ligase Q00987 4193 12q15 human S386-p 11956709 DDKITQAsQSQESED molecular association, regulation; ubiquitination; enzymatic activity, inhibited; protein conformation MDM2(DISRUPTS); p53(DISRUPTS) 19816404; 21986495 3 2 0 oligomerization inhibited; phospho-mimic mutant is defective for p53 poly-ubiquitination -PLK4 PLK4 EC 2.7.11.21; KINASE; Kinase, protein; Nucleolus; Protein kinase, Other; Protein kinase, Ser/Thr (non-receptor) O00444 10733 4q28.1 human T170-p 480636 MPHEKHYtLCGTPNY Pkinase molecular association, regulation; enzymatic activity, induced STIL(INDUCES) 26101219 2 1 1 -HCST HCST Adaptor/scaffold; Membrane protein, integral Q9UBK5 10870 19q13.12 human Y86-p 23112287 AQEDGKVyINMPGRG DAP10 intracellular localization 25002577 1 1 1 recruitment of PI3K, GRB2 & GRB7 -Map3k4 MEKK4 EC 2.7.11.25; KINASE; Kinase, protein; Protein kinase, STE; Protein kinase, Ser/Thr (non-receptor) O08648 26407 17 8.42 cM|17 A1 mouse S116-p 20804890 KMNTPSQsPHKDLGK MEKK4_N molecular association, regulation; enzymatic activity, induced GADD45A(INDUCES) 27358404 1 5 0 -Plk4 PLK4 EC 2.7.11.21; KINASE; Kinase, protein; Nucleolus; Protein kinase, Other; Protein kinase, Ser/Thr (non-receptor) Q64702 20873 3|3 B mouse S297-p 12654005 LSTTITAsSGTSLSG protein degradation; ubiquitination 20100909 2 1 0 -FOXO4 FOXO4 DNA-binding; Oncoprotein; Transcription factor P98177 4303 Xq13.1 human K189-ac 459043 PEGGKSGkAPRRRAA Forkhead activity, inhibited transcription, inhibited 12964026 2 1 0 -RBM17 RBM17 RNA splicing; RNA-binding; Spliceosome Q96I25 84991 10p15.1 human S288-p 27936103 DATEKDAsKKSDSNP molecular association, regulation; phosphorylation cell motility, induced RNA(DISRUPTS) 23519612 1 0 0 induced cell invasion, enhanced Cortactin phosphorylation at ERK-dependent sites -Stk11 LKB1 Autophagy; EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, CAMK; Protein kinase, Ser/Thr (non-receptor); Tumor suppressor Q9WTK7 20869 10|10 C1 mouse Y365-p 13258701 DIEDGIIyTQDFTVP molecular association, regulation; intracellular localization; phosphorylation cell differentiation, induced; signaling pathway regulation PLCG1(INDUCES); LAT(INDUCES); Fyn(INDUCES) 20142099; 21487392; 24586906 3 0 0 TCR signaling, recruitment of PLCG1 to the LAT signalosome; mutation of this site increses AMPK phosphorylation; LKB1 cytosolic localization, induced AMPK phosphorylation -MAPK7 ERK5 EC 2.7.11.24; KINASE; Kinase, protein; Protein kinase, CMGC; Protein kinase, Ser/Thr (non-receptor) Q13164 5598 17p11.2 human Y221-p 448206 HQYFMTEyVATRWYR Pkinase cell cycle regulation; carcinogenesis, induced; cell motility, induced; apoptosis, inhibited; transcription, induced 20138986; 31980741; 34655447 20 28 955 -Pax6 PAX6 DNA-binding; Motility/polarity/chemotaxis; Transcription factor P63015 18508 2 E3|2 55.31 cM mouse T281-p 458808 QRRQASNtPSHIPIS transcription, induced 16407227 1 0 0 -NR3C1 GR DNA-binding; Mitochondrial; Nuclear receptor; Transcription factor P04150 2908 5q31.3 human T556-p 1872513510 DSSVPDStWRIMTTL Hormone_recep molecular association, regulation 14-3-3 zeta(INDUCES) 33744286 1 0 0 -FPR1 FPR1 GPCR, family 1; Membrane protein, integral; Membrane protein, multi-pass; Motility/polarity/chemotaxis; Receptor, GPCR P21462 2357 19q13.41 human S342-p 450850 ATNSTLPsAEVELQA molecular association, regulation cell motility, induced GRK2(DISRUPTS) 22447027 1 0 0 -MYO9B MYO9B Actin-binding; GAP; GAP, Rac/Rho; Motility/polarity/chemotaxis; Motor Q13459 4650 19p13.11 human T1271-p 471989 APGSAPEtPEDKSKP cell differentiation, inhibited 30872405 1 45 59 -Ap2b1 AP2B1 Vesicle P62944 140670 10q26 rat Y888-p 462927 VEGQDMLyQSLKLTN B2-adapt-app_C molecular association, regulation endocytosis, altered ARRB1(DISRUPTS); LDLRAP1(DISRUPTS) 24798335 1 6 46 phosphomimetic Y888E mutation disrupts binding -NFE2L2 NRF2 DNA-binding; Transcription factor Q16236 4780 2q31.2 human S558-p 10292703 HLLKKQLsTLYLEVF bZIP_Maf protein stabilization; intracellular localization cell differentiation, inhibited; transcription, induced 19668370; 37126714 3 2 0 -WRN WRN Cell cycle regulation; DNA repair, damage; DNA-binding; EC 3.6.4.12; Helicase; Nucleolus Q14191 7486 8p12 human S440-p 3196118 DTSYVIEsDEDLEME intracellular localization DNA repair, induced 24429382 2 17 2 localization to nucleoli, protection of cells from DSBs produced by etoposide -PRKCQ PKCT EC 2.7.11.13; KINASE; Kinase, protein; Protein kinase, AGC; Protein kinase, Ser/Thr (non-receptor) Q04759 5588 10p15.1 human T219-p 457380 SAINSREtMFHKERF intracellular localization 16252004 2 1 0 phosphorylation of site may be important in antigen receptor-mediated signaling -PDE4D PDE4D iso2 EC 3.1.4.53; Nucleotide Metabolism - purine; Phosphodiesterase Q08499-2 5144 5q11.2-q12.1 human S13-p 2188800 NFPFRRHsWICFDVD molecular association, regulation NDEL1(DISRUPTS); AKAP6(INDUCES) 15182229; 18845247 5 3 0 -Hmga2 HMGA2 DNA-binding; Oncoprotein P52927 15364 10 D2|10 67.94 cM mouse S59-p 11452900 PKGSKNKsPSKAAQK molecular association, regulation; protein conformation DNA(DISRUPTS) 10636877 1 2 0 -MORC3 MORC3 Cell cycle regulation; RNA-binding Q14149 23515 21q22.12 human K650-sm 14988619 EVPSLVVkKEETVED molecular association, regulation PML(INDUCES) 20501696 1 3 0 -TCF7L2 TCF7L2 Apoptosis; Cell cycle regulation; Cell development/differentiation; DNA-binding; Motility/polarity/chemotaxis; Transcription factor Q9NQB0 6934 10q25.2-q25.3 human T212-p 11499002 TYSNEHFtPGNPPPH CTNNB1_binding molecular association, regulation DNA(DISRUPTS) 12556497 1 0 0 Beta-catenin-TCF7L2 complex DNA binding -CDCA5 CDCA5 Cell cycle regulation Q96FF9 113130 11q13.1 human S126-p 20727702 NPEAESSsKEGELDA Sororin activity, inhibited cell cycle regulation SCC-112(DISRUPTS) 23901111 1 2 0 -APEX1 APE1 DNA repair, damage; DNA-binding; Deoxyribonuclease; EC 4.2.99.18; Endoplasmic reticulum; Hydrolase; Lyase; Nuclear receptor co-regulator; Nucleolus; Transcription, coactivator/corepressor P27695 328 14q11.2 human R301-me 1877347600 ALCDSKIrSKALGSD Exo_endo_phos molecular association, regulation TOM20(INDUCES) 32679368 1 0 0 mitochondrial translocation -TCERG1 TCERG1 RNA-binding; Spliceosome; Transcription factor O14776 10915 5q32 human K503-sm 13258711 EEPIKEIkEEPKEEE transcription, inhibited 20215116 1 2 0 sumoylation negatively regulates TCERG transcriptional activity -Chmp5 CHMP5 Cell cycle regulation; Vesicle Q9D7S9 76959 4|4 A5 mouse S30-p 36130689 TVDSRAEsIDKKISR Snf7 protein stabilization USP8(INDUCES) 28553951 1 4 0 -SHC1 SHC1 iso2 Adaptor/scaffold; Apoptosis; Mitochondrial; Motility/polarity/chemotaxis P29353-2 6464 1q21.3 human Y239-p 448509 EEPPDHQyYNDFPGK activity, induced; molecular association, regulation; activity, inhibited; phosphorylation cell growth, induced; cell motility, altered; transcription, induced; cytoskeletal reorganization GRB2(INDUCES); SHIP(INDUCES); GRB2(DISRUPTS); ZAP70(INDUCES); VAV1(INDUCES) 10598576; 10891441; 17537990; 9121430; 9710204; 9813159 32 22 947 Y317F activates MAPK; f-actin cytoskeleton, chemotaxis. -Zfp36 TTP DNA-binding; RNA-binding P22893 22695 7 A3-B1|7 16.72 cM mouse S52-p 451150 RLTGRSTsLVEGRSC activity, induced; protein stabilization; molecular association, regulation; intracellular localization; activity, inhibited translation, altered; transcription, induced 14-3-3 beta(INDUCES); CAF-1A(DISRUPTS); CAF-1B(DISRUPTS) 15014438; 16508015; 20595389; 26002976; 26019272; 31527197; 36961408 11 16 0 -CERS5 LASS5 DNA-binding; EC 2.3.1.24; Membrane protein, integral; Membrane protein, multi-pass; Transferase Q8N5B7 91012 12q13.12 human S350-p 18260879 KVSKDDRsDVESSSE enzymatic activity, induced 26887952 1 6 0 -PRKD1 PRKD1 Autophagy; EC 2.7.11.13; KINASE; Kinase, protein; Motility/polarity/chemotaxis; Protein kinase, CAMK; Protein kinase, Ser/Thr (non-receptor) Q15139 5587 14q12 human S208-p 455754 RRRLSNVsLTGVSTI molecular association, regulation 14-3-3 beta(INDUCES) 15755722 2 23 13 -Lcp2 SLP76 Adaptor/scaffold Q60787 16822 11|11 A4 mouse Y128-p 448219 DGEDDGDyESPNEEE molecular association, regulation; phosphorylation cell differentiation, altered; apoptosis, altered; cytoskeletal reorganization; cell adhesion, altered; transcription, induced; signaling pathway regulation; transcription, altered VAV1(INDUCES) 11313406; 12640123; 16456002; 18342008; 18663126; 22291096; 9047237 25 1 0 mutation of this site impairs thrombus formation; required for intergrin activation -BRSK2 BRSK2 EC 2.7.11.1; EC 2.7.11.26; KINASE; Kinase, protein; Protein kinase, CAMK; Protein kinase, Ser/Thr (non-receptor) Q8IWQ3 9024 11p15.5 human T260-p 470033 VDAARRLtLEHIQKH Pkinase enzymatic activity, induced 16870137 2 0 0 -NABP2 OBFC2B Cell cycle regulation; DNA repair, damage Q9BQ15 79035 12q13.3 human K79-sm 1877008701 KGYASVFkGCLTLYT tRNA_anti-codon protein stabilization; molecular association, regulation apoptosis, induced NBS1(INDUCES) 32576812 1 0 0 recruitment of the MRN complex to DSB sites, sumoylation enhances the sensitivity of cancer cells to DNA damage agents -Ctnnb1 CTNNB1 Actin-binding; Cell adhesion; Motility/polarity/chemotaxis; Nuclear receptor co-regulator; Oncoprotein; Transcription factor Q9WU82 84353 8q32 rat S45-p 447488 GATTTAPsLSGKGNP protein degradation 14985333 57 7 0 -Hmgcs2 HMGCS2 Amino Acid Metabolism - valine, leucine and isoleucine degradation; Carbohydrate Metabolism - butanoate; EC 2.3.3.10; Lipid Metabolism - synthesis and degradation of ketone bodies; Mitochondrial; Secondary Metabolites Metabolism - terpenoid backbone biosynthesis; Transferase P54869 15360 3 F2.2|3 42.74 cM mouse K310-sc 33339742 PFCKMVQkSLARLMF HMG_CoA_synt_C enzymatic activity, inhibited 24315375 0 2 0 K83E or K310E mutants lose enzymatic activity -FOXK2 FOXK2 DNA-binding; Transcription factor Q01167 3607 17q25.3 human S373-p 3193955 SSRSAPAsPNHAGVL protein stabilization apoptosis, altered; transcription, altered 20810654 1 24 29 -JUNB JunB Motility/polarity/chemotaxis; Oncoprotein; Transcription factor P17275 3726 19p13.13 human S79-p 454237 QGSDTGAsLKLASSE Jun activity, induced transcription, altered p300(INDUCES) 15308641 2 0 0 -P2rx3 P2X3 Channel, ligand-gated; Membrane protein, integral; Membrane protein, multi-pass P49654 81739 3q24 rat T388-p 33402211 ATVEKQStDSGAYSI activity, induced; molecular association, regulation; intracellular localization caveolin-1(INDUCES) 24755854 1 0 0 induced receptor membrane insertion, enhanced P2X3 receptor response at cell membrane -STK11 LKB1 iso2 Autophagy; EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, CAMK; Protein kinase, Ser/Thr (non-receptor); Tumor suppressor Q15831-2 6794 19p13.3 human S399-p 27933602 DLSGEEAsRPAPQ__ intracellular localization; enzymatic activity, induced 23612973 1 0 0 S399 is required for metformin activation of AMPK.; translocation from nucleus to cytosol -Trim28 TIF1B EC 6.3.2.-; KINASE; Kinase, protein; Ligase; Nuclear receptor co-regulator; Protein kinase, atypical; SUMO LIGASE; SUMO ligase; Transcription, coactivator/corepressor; UBIQUITIN LIGASE; Ubiquitin conjugating system; Ubiquitin ligase Q62318 21849 7|7 A1 mouse K575-sm 3142605 APEGPETkPVLMPLT transcription, inhibited 17298944 2 4 0 -HRH1 H1R GPCR, family 1; Membrane protein, integral; Membrane protein, multi-pass; Receptor, GPCR P35367 3269 3p25.3 human S398-p 450937 WKRLRSHsRQYVSGL 7tm_1 receptor desensitization, altered; receptor internalization, altered 10101032; 15107581; 15328002 4 0 0 -Kcnj10 Kir4.1 Channel, ligand-gated; Channel, potassium; Membrane protein, integral; Membrane protein, multi-pass P49655 29718 13q24 rat S377-p 2243103 SALSVRIsNV_____ molecular association, regulation; intracellular localization MAGI1(DISRUPTS) 18303016 1 1 0 -Ctnnb1 CTNNB1 Actin-binding; Cell adhesion; Motility/polarity/chemotaxis; Nuclear receptor co-regulator; Oncoprotein; Transcription factor Q02248 12387 9 F4|9 72.19 cM mouse Y86-p 447584 VADIDGQyAMTRAQR intracellular localization transcription, induced 27572314 9 1 22 translocation to nucleus -ACTB ACTB Cytoskeletal; Motility/polarity/chemotaxis P60709 60 7p22.1 human K68-m3 1877292603 KRGILTLkYPIEHGI Actin cell motility, induced; cytoskeletal reorganization 33008892 2 1 0 -PPM1G PPM1G EC 3.1.3.16; Motility/polarity/chemotaxis; PHOSPHATASE; Protein phosphatase, Ser/Thr (non-receptor); Spliceosome O15355 5496 2p23.3 human S183-p 460849 GTGEEPGsQGLNGEA molecular association, regulation RNA(INDUCES) 26324325 1 12 67 -SIAH2 SIAH2 EC 6.3.2.-; EC 6.3.2.19; Ligase; Transcription, coactivator/corepressor; UBIQUITIN LIGASE; Ubiquitin conjugating system; Ubiquitin ligase O43255 6478 3q25.1 human T119-p 26371004 PTCRGALtPSIRNLA protein degradation; intracellular localization; enzymatic activity, induced cytoskeletal reorganization 22878263; 23044042; 26751770 3 3 0 -SOX2 SOX2 Cell development/differentiation; DNA-binding; Transcription factor P48431 6657 3q26.33 human S250-p 6738003 VVKSEASsSPPVVTS molecular association, regulation cell cycle regulation; cell differentiation, induced Oct4(INDUCES) RNA(INDUCES) 34497381 1 4 0 -Dab1 DAB1 iso2 Adaptor/scaffold P97318-2 13131 4 C6|4 47.79 cM mouse S481-p 479420 STTPSTNsPPTPAPR phosphorylation 16529723 1 0 0 inhibits tyrosine phosphorylation -Axin1 axin 1 Adaptor/scaffold; Tumor suppressor O70239 79257 10q12 rat S325-p 2226510 ANDSEQQsLSSDADT cytoskeletal reorganization 22933777 1 0 0 Phosphorylation regulates responsive to Sema3A induced growth cone collapse. -BRSK2 BRSK2 EC 2.7.11.1; EC 2.7.11.26; KINASE; Kinase, protein; Protein kinase, CAMK; Protein kinase, Ser/Thr (non-receptor) Q8IWQ3 9024 11p15.5 human T443-p 17551641 PRGSPLPtPKGTPVH enzymatic activity, inhibited 23629625 2 2 0 -STAT2 STAT2 DNA-binding; Transcription factor P52630 6773 12q13.3 human S393-p 1869778702 LTPEKGQsQGLIWDF STAT_bind protein degradation; molecular association, regulation; ubiquitination carcinogenesis, inhibited; cell growth, inhibited; signaling pathway regulation FBXW7(INDUCES) 31843895 1 0 0 by FBXW7 interaction; FBXW7-STAT2 interaction regulate melanoma cell and colony growth -SNAI2 Snail2 Apoptosis; C2H2-type zinc finger protein; Motility/polarity/chemotaxis; Transcription factor O43623 6591 8q11.21 human S54-p 31961400 ILSSGAYsPITVWTT protein degradation; ubiquitination cell cycle regulation 24662826 1 0 0 -Dusp8 DUSP8 EC 3.1.3.16; EC 3.1.3.48; Motility/polarity/chemotaxis; PHOSPHATASE; Protein phosphatase, dual-specificity O09112 18218 7 F5|7 87.59 cM mouse S515-p 22598803 GWVPPLDsPGTPSPD enzymatic activity, inhibited signaling pathway regulation 22100391 1 1 0 activates JNK pathway -PTPN7 HePTP EC 3.1.3.48; Motility/polarity/chemotaxis; PHOSPHATASE; Protein phosphatase, tyrosine (non-receptor) P35236 5778 1q32.1 human S246-p 460715 QYQEERRsVKHILFS Y_phosphatase intracellular localization; enzymatic activity, induced 16479000 1 0 0 inhibits TCR-induced gene activation -SLC6A3 DAT Membrane protein, integral; Membrane protein, multi-pass; Transporter; Transporter, SLC family Q01959 6531 5p15.33 human S13-p 451138 CSVGLMSsVVAPAKE activity, induced 16908408 4 0 0 stimulates DAT-mediated efflux of dopamine -RET Ret EC 2.7.10.1; KINASE; Kinase, protein; Membrane protein, integral; Oncoprotein; Protein kinase, TK; Protein kinase, tyrosine (receptor) P07949 5979 10q11.21 human S696-p 451267 SSGARRPsLDSMENQ molecular association, regulation; enzymatic activity, induced cytoskeletal reorganization 11886862; 20682772 5 7 0 regulation of Rac activation and GDNF induced lamellipodia formation.; inhibits interaction of SHP2 with Ret Y687 -Rnd3 RhoE G protein; G protein, monomeric; G protein, monomeric, Rho; Motility/polarity/chemotaxis P61588 74194 2|2 C1.1 mouse K235-ub 40212800 AVATDLRkDKAKSCT protein degradation cell cycle regulation 24045951 1 0 0 -BRD4 BRD4 KINASE; Kinase, protein; Protein kinase, Ser/Thr (non-receptor); Protein kinase, atypical O60885 23476 19p13.12 human R183-m1 57691848 AKGRGRGrKETGTAK carcinogenesis, induced; DNA repair, induced; cell growth, induced; transcription, induced 36475791 1 2 0 -Steap4 STEAP4 EC 1.16.1.-; Membrane protein, integral; Membrane protein, multi-pass; Oxidoreductase Q923B6 117167 5|5 A1 mouse K18-ub 27211122 LTTDSSEkQGVVCIF protein degradation 35747386 1 2 0 -DRD2 DRD2 GPCR, family 1; Membrane protein, integral; Membrane protein, multi-pass; Receptor, GPCR P14416 1813 11q23.2 human K258-ub 1877221609 KLCTVIMkSNGSFPV 7tm_1 protein degradation 32572597 1 0 0 -MEF2D MEF2D DNA-binding; Transcription factor Q14814 4209 1q22 human S98-p 470518 KGFNGCDsPEPDGED HJURP_C molecular association, regulation; ubiquitination SKP2(INDUCES) 25733682 2 24 5 -Sh3glb1 endophilin B1 Apoptosis; Autophagy; EC 2.3.1.-; Mitochondrial; Transferase Q9JK48 54673 3|3 H2 mouse T145-p 26318403 TSALNFLtPLRNFIE BAR molecular association, regulation; protein conformation autophagy, induced beclin 1(INDUCES); UVRAG(INDUCES) 21499257 2 0 0 dimerization; neuronal cell loss -Syngap1 SynGAP GAP; GAP, Ras F6SEU4 240057 17|17 A3.3 mouse S857-p 37045603 GPGGRLNsSSVSNLA DUF3498 activity, induced 25533468 1 1 0 phosphorylation of this site increases HRas GAP activity of S88A/T790A/S817A SunGAP mutant -PLCB1 PLCB1 Carbohydrate Metabolism - inositol phosphate; EC 3.1.4.11; Phospholipase Q9NQ66 23236 20p12.3 human S887-p 450172 HSQPAPGsVKAPAKT intracellular localization 21338571 3 1 0 -F2RL1 F2RL1 GPCR, family 1; Membrane protein, integral; Membrane protein, multi-pass; Receptor, GPCR P55085 2150 5q13.3 human S388-p 15409901 RKSSSYSsSSTTVKT receptor desensitization, induced; molecular association, regulation; phosphorylation signaling pathway regulation ARRB1(INDUCES); ARRB2(INDUCES) 33073187 1 0 3 inhibits ERK phosphorylation and signaling; regulates calcium signaling -RYR1 RYR1 Channel, calcium; Membrane protein, integral; Membrane protein, multi-pass; Transporter; Transporter, ion channel P11716 100009540 rabbit S2843-p 451818 KKKTRKIsQTAQTYD molecular association, regulation CAMK2B(INDUCES) 22913516 12 8 0 20% reduction in binding with S2843A mutant -H3C14 HIST2H3A/C/D DNA-binding Q71DI3 126961 1q21.2 human K9-ac 18465124 RTKQTARkSTGGKAP Histone chromatin organization, altered; transcription, induced 20075197 1 5 55 -OFD1 OFD1 Cell cycle regulation O75665 8481 Xp22.2 human S735-p 480374 GTSSRRLsSTPLPKA protein degradation; molecular association, regulation; ubiquitination transcription, induced; cytoskeletal reorganization; signaling pathway regulation WDR67(INDUCES) 33934390 1 13 12 induces SHH pathway -orf9b Accessory protein 9b P0DTD2 SARSCoV2 K4-ub 1883454306 ____MDPkISEMHPA protein degradation; ubiquitination 35638730 1 0 0 reduces ORF9b-mediated IFN and NF-kB inhibition -HAVCR1 TIM-1 Membrane protein, integral Q96D42 26762 5q33.3 human Y355-p 20842101 VQAEDNIyIENSLYA receptor internalization, altered; intracellular localization 29321304 2 0 7 receptor surface of 350A mutant, 350A mutant enhanced HCV infection -EPHA4 EphA4 EC 2.7.10.1; KINASE; Kinase, protein; Membrane protein, integral; Protein kinase, TK; Protein kinase, tyrosine (receptor) P54764 2043 2q36.1 human Y779-p 450858 EDDPEAAyTTRGGKI PK_Tyr_Ser-Thr enzymatic activity, induced 21439481 2 33 700 -Jak2 JAK2 EC 2.7.10.2; KINASE; Kinase, protein; Oncoprotein; Protein kinase, TK; Protein kinase, tyrosine (non-receptor) Q62120 16452 19 C1|19 23.73 cM mouse S523-p 465671 GISDVQIsPTLQRHN enzymatic activity, inhibited; phosphorylation 16705159; 16705160; 19364823 4 21 1 -Sdc4 syndecan-4 Cell adhesion; Membrane protein, integral; Motility/polarity/chemotaxis P34901 24771 3q42 rat S183-p 449863 MKKKDEGsYDLGKKP Syndecan protein conformation cell adhesion, induced; cell motility, inhibited 16310216; 22504297 11 1 0 decreased Rho A activation -IKZF1 Ikaros C2H2-type zinc finger protein; DNA-binding; Transcription factor Q13422 10320 7p12.2 human S364-p 4714822 GTPRSNHsAQDSAVE molecular association, regulation; intracellular localization cell differentiation, induced; transcription, induced DNA(INDUCES) 23071339 1 8 0 induces transcription of DNAJC6, EIF4e3, TNFAIP8L2; nuclear localization -RPL11 RPL11 Motility/polarity/chemotaxis; Nucleolus; Ribosomal; Translation P62913 6135 1p36.11 human K52-ne 12067604 GQTPVFSkARYTVRS Ribosomal_L5 protein stabilization; intracellular localization 19713960 1 0 0 -Jak2 JAK2 EC 2.7.10.2; KINASE; Kinase, protein; Oncoprotein; Protein kinase, TK; Protein kinase, tyrosine (non-receptor) Q62120 16452 19 C1|19 23.73 cM mouse Y1008-p 448408 LPQDKEYyKVKEPGE PK_Tyr_Ser-Thr ubiquitination; enzymatic activity, induced carcinogenesis, induced; cell growth, induced; signaling pathway regulation 16705159; 16705160; 18160720; 20304997; 21685897; 24614172; 33539470; 36356831; 36400972 77 2 16 -ZAP70 ZAP70 EC 2.7.10.2; KINASE; Kinase, protein; Protein kinase, TK; Protein kinase, tyrosine (non-receptor) P43403 7535 2q11.2 human Y474-p 455368 VLLVNRHyAKISDFG PK_Tyr_Ser-Thr activity, induced; molecular association, regulation SHC1(INDUCES) 9685404 1 0 3 -Kcnj4 HIR Channel, potassium; Membrane protein, integral; Membrane protein, multi-pass P52190 116649 7q34 rat S444-p 9819904 NISYRREsAI_____ molecular association, regulation TAX1BP3(DISRUPTS) 19635485 1 0 0 -TOPORS TOPORS Cell cycle regulation; EC 6.3.2.-; EC 6.3.2.19; Ligase; SUMO LIGASE; SUMO conjugating system; SUMO ligase; UBIQUITIN LIGASE; Ubiquitin conjugating system; Ubiquitin ligase Q9NS56 10210 9p21.1 human S718-p 5938002 KDRDGYEsSYRRRTL protein degradation; sumoylation; ubiquitination; enzymatic activity, altered cell cycle regulation 19473992; 19821153; 26872363 3 2 0 -PPARGC1A PGC-1 alpha Nuclear receptor co-regulator; Transcription, coactivator/corepressor Q9UBK2 10891 4p15.2 human K278-ac 63355301 KGSPFENkTIERTLS transcription, inhibited 28340340 0 1 0 -Foxo3 FOXO3A Autophagy; DNA-binding; Oncoprotein; Transcription factor Q9WVH4 56484 10 B2|10 22.79 cM mouse S208-p 464289 SSAGWKNsIRHNLSL Forkhead protein stabilization 24453252 4 0 0 -RIF1 RIF1 DNA repair, damage Q5UIP0 55183 2q23.3 human S2205-p 3201699 VNKVRRVsFADPIYQ molecular association, regulation; enzymatic activity, inhibited cell cycle regulation PPP2R2C(DISRUPTS); PPP2R3B(INDUCES); PPP2R5C(DISRUPTS); PPP2R3A(INDUCES) 31209037; 32900880 5 20 77 -PSEN1 PSEN1 Cell surface; EC 3.4.23.-; Membrane protein, integral; Membrane protein, multi-pass; Mitochondrial; Protease P49768 5663 14q24.2 human S366-p 3191056 AAVQELSsSILAGED Presenilin protein conformation 28132667 1 14 0 PS1 pathogenic conformational shift -Ephb2 EphB2 EC 2.7.10.1; KINASE; Kinase, protein; Membrane protein, integral; Protein kinase, TK; Protein kinase, tyrosine (receptor); Tumor suppressor P54763 13844 4 D3|4 69.0 cM mouse Y742-p 448330 KYLADMNyVHRDLAA PK_Tyr_Ser-Thr protein conformation 16977320 3 4 0 modulates conformation of the activation section of EphB2 (residues Y604-Y610) -Pparg PPAR-gamma iso2 DNA-binding; Nuclear receptor; Transcription factor P37238-2 19016 6 E3|6 53.41 cM mouse K365-sm 12004433 FGDFMEPkFEFAVKF Hormone_recep molecular association, regulation transcription, altered; transcription, inhibited HDAC3(INDUCES); N-CoR1(INDUCES) 16127449; 23826177 8 0 0 necessary for ligand-induced reduction of sumoylation -Nr0b2 NR0B2 Nuclear receptor; Nuclear receptor co-regulator; Transcription, coactivator/corepressor Q62227 23957 4 D2.3|4 66.25 cM mouse T58-p 28702400 RLCAPHRtCREALDV Hormone_recep molecular association, regulation; intracellular localization autophagy, induced; transcription, induced SREBP-2(INDUCES); AHR(INDUCES) DNA(INDUCES) 26634251; 35686465; 37348559 4 0 0 -PLCG2 PLCG2 Carbohydrate Metabolism - inositol phosphate; EC 3.1.4.11; Motility/polarity/chemotaxis; Phospholipase P16885 5336 16q23.3 human T1045-p 25692905 LQPESMRtEKYDPMP signaling pathway regulation 22759789 1 0 0 B cell receptor signaling -TOP2A TOP2A EC 5.99.1.3; Isomerase P11388 7153 17q21.2 human S1247-p 452238 KNENTEGsPQEDGVE sumoylation; intracellular localization cell cycle regulation 30871006 2 63 4 -CGAS cGAS EC 2.7.7.86 Q8N884 115004 6q13 human K414-ac 11322517 KDCLKLMkYLLEQLK Mab-21_C enzymatic activity, inhibited; protein conformation; activity, inhibited apoptosis, inhibited 30799039; 32345711; 33438687 3 3 0 -Camk2b CAMK2B EC 2.7.11.17; KINASE; Kinase, protein; Protein kinase, CAMK; Protein kinase, Ser/Thr (non-receptor) P08413 24245 14q21 rat T382-p 48915804 AALEPQTtVIHNPVD molecular association, regulation 26291163 1 2 0 inhibits interaction with F-actin, regulates synaptic plasticity -MDM2 MDM2 EC 6.3.2.-; EC 6.3.2.19; Inhibitor; Ligase; NEDDYLATION LIGASE; Neddylation Ligase; Nucleolus; Oncoprotein; UBIQUITIN LIGASE; Ubiquitin conjugating system; Ubiquitin ligase Q00987 4193 12q15 human S242-p 454921 WLDQDSVsDQFSVEF activity, induced 12167711 3 1 0 promotes p53 degradation -Sstr2 SSTR2 GPCR, family 1; Membrane protein, integral; Membrane protein, multi-pass; Receptor, GPCR P30680 rat T353-p 7652102 DKSRLNEtTETQRTL activity, induced; intracellular localization; receptor internalization, altered signaling pathway regulation 21493671; 21795688 9 0 1 Dephosphorylation is initiated directly after receptor activation at or near the plasma membrane; leads to disruption of the ?-arrestin- GPCR complex -H1-2 H1C DNA-binding P16403 3006 6p22.2 human T165-p 18910728 AKKPAAAtVTKKVAK cell growth, altered 24873882 1 3 0 -Dzip1 DZIP1 C2H2-type zinc finger protein Q8BMD2 66573 14|14 E4 mouse S714-p 21241900 DTDWTEGsEMDDSDF transcription, induced; signaling pathway regulation 21878643 1 1 0 involved in Gli1 nad Gli3 turnover pathway -TLN1 talin 1 Cytoskeletal; Motility/polarity/chemotaxis Q9Y490 7094 9p13.3 human K2454-me 1873284342 DQDSEAMkRLQAAGN I_LWEQ carcinogenesis, induced; cell growth, induced; cytoskeletal reorganization; cell adhesion, altered VAV1(INDUCES) 28967906 1 0 0 induces STAT3 activation and phosphorylation -RCHY1 RCHY1 EC 6.3.2.-; EC 6.3.2.19; Nuclear receptor co-regulator; UBIQUITIN LIGASE; Ubiquitin conjugating system; Ubiquitin ligase Q96PM5 25898 4q21.1 human T154-p 483981 ICLEDIHtSRVVAHV zf-RING_2 ubiquitination; intracellular localization; enzymatic activity, inhibited cell growth, altered p53(DISRUPTS) 17568776 1 1 0 cytoplasmic localization -Tbc1d1 TBC1D1 DEUBIQUITINASE; GAP; GAP, Rab; Ubiquitin-specific protease Q60949 57915 5 C3.1|5 32.8 cM mouse S501-p 3996102 AKRSLTEsLESILSR activity, inhibited 19740738 1 10 2 reduces inhibitory effect on TBC1D1 on GLUT4 translocation -STARD3 STARD3 Membrane protein, integral; Membrane protein, multi-pass Q14849 10948 17q12 human S213-p 12738030 QFYSPPEsFAGSDNE MENTAL molecular association, regulation VAPA(INDUCES) 35231443 1 3 0 -POLM POLM DNA repair, damage; EC 2.7.7.7; Transferase Q9NP87 27434 7p13 human S372-p 28758702 HQHSCCEsPTRLAQQ DNA_pol_B_palm molecular association, regulation; enzymatic activity, inhibited; protein conformation DNA(DISRUPTS) 23933132; 31138645 2 0 0 Increase the stability of Loop1 -BACE1 BACE EC 3.4.23.46; Membrane protein, integral; Protease P56817 23621 11q23.3 human K126-ac 478256 STYRDLRkGVYVPYT Asp protein stabilization; intracellular localization 17425515 1 1 1 regulates translocation through secretory pathway -PRPF3 PRPF3 RNA processing; RNA splicing; Spliceosome O43395 9129 1q21.2 human K559-sm 1872852110 SNPAKKFkIEANAGQ DUF1115 molecular association, regulation RNA splicing, induced EFTUD2(INDUCES); SF3A1(INDUCES); PRP4(INDUCES) 28379520 1 0 0 -HMGN1 HMGN1 DNA-binding; Nuclear receptor co-regulator P05114 3150 21q22.2 human K61-ac 458853 GKRGAKGkQAEVANQ HMG14_17 molecular association, regulation DNA(DISRUPTS) 10753971 1 2 0 -PGR PR DNA-binding; Nuclear receptor; Transcription factor P06401 5241 11q22.1 human S676-p 450154 LSQRFTFsPGQDIQL transcription, induced 8662865 2 2 0 -SRF SRF Motility/polarity/chemotaxis; Transcription factor P11831 6722 6p21.1 human S251-p 13203802 TDLTYQVsESDSSGE transcription, inhibited 8375385 1 0 0 -Snap25 SNAP-25 Vesicle P60881 25012 3q36 rat T138-p 449875 GGFIRRVtNDARENE SNAP-25 molecular association, regulation neural plasticity; exocytosis, inhibited; signaling pathway regulation STX1A(DISRUPTS) 26721188; 30728295 7 5 3 -DNAJB8 DNAJB8 Chaperone Q8NHS0 165721 3q21.3 human K216-ac 12615902 VEEDGQLkSVTVNGK activity, induced 20159555 1 1 0 -NRIP1 RIP140 Nuclear receptor co-regulator; Transcription, coactivator/corepressor P48552 8204 21q11.2-q21.1 human K756-sm 2798318 QILMVKIkSEPCDDL NRIP1_repr_3 intracellular localization transcription, inhibited 18211901 1 1 0 -CCDC6 CCDC6 Apoptosis; Cytoskeletal; Oncoprotein Q16204 8030 10q21.2 human K266-sm 27992503 MRHIRFLkNEVERLK DUF2046 intracellular localization transcription, induced; signaling pathway regulation 23145146 1 0 0 cyclic AMP activity -TGFB1I1 Hic-5 Motility/polarity/chemotaxis; Nuclear receptor co-regulator; Transcription, coactivator/corepressor O43294 7041 16p11.2 human Y60-p 450964 SGDKDHLySTVCKPR Paxillin molecular association, regulation; activity, inhibited transcription, altered SH2D1B(NOT_REPORTED); CSK(INDUCES); AR(DISRUPTS) 10838081; 11856738; 23322602 3 7 20 -CTDSP1 CTDSP1 EC 3.1.3.16; PHOSPHATASE; Protein phosphatase, Ser/Thr (non-receptor) Q9GZU7 58190 2q35 human S245-p 40684504 LPFFEQLsRVDDVYS NIF enzymatic activity, inhibited cell growth, inhibited 25893300 1 0 0 -Mark2 MARK2 EC 2.7.11.1; EC 2.7.11.26; KINASE; Kinase, protein; Protein kinase, CAMK; Protein kinase, Ser/Thr (non-receptor) O08679 60328 1q43 rat T539-p 453427 RGVSSRStFHAGQLR enzymatic activity, inhibited 16717194 5 19 1 -Pxn PXN Adaptor/scaffold; Cell adhesion; Cytoskeletal; Motility/polarity/chemotaxis Q8VI36 19303 5 F|5 56.1 cM mouse S126-p 450227 SFPNKQKsAEPSPTV Paxillin cell motility, altered; cytoskeletal reorganization 16537926 8 28 4 regulates cells spreading -KCNA5 Kv1.5 Channel, potassium; Membrane protein, integral; Membrane protein, multi-pass P22460 3741 12p13.32 human S592-p 1269647506 KCNVKAKsNVDLRRS activity, inhibited 30279167 1 0 0 mediates HPV -Ghr GH receptor Membrane protein, integral; Receptor, cytokine P16310 25235 2q16 rat Y487-p 450479 SLANIDFyAQVSDIT GHBP molecular association, regulation SHP-2(INDUCES) 10976913 2 0 0 Minor SHP-2 interacting phosphorylation site. -VCP VCP Chaperone; DNA repair, damage; EC 3.6.4.6; Endoplasmic reticulum; Hydrolase P55072 7415 9p13.3 human S664-p 7435526 LKANLRKsPVAKDVD molecular association, regulation; intracellular localization; phosphorylation cell cycle regulation OTUB1(INDUCES); CLN3(INDUCES) 29950310 1 2 0 Cdc48 in the stabilization of Cln3 in the nucleus, regulates G1-cyclin activity for cell cycle entry, enhanced pRB phosphorylation -FYB2 ARAP Adaptor/scaffold Q5VWT5 199920 1p32.2 human Y491-p 56614902 SSISEEIyDDVEYSR molecular association, regulation; intracellular localization signaling pathway regulation SLP76(INDUCES) 27335501 1 0 0 -Bid BID Apoptosis; Mitochondrial P70444 12122 6 F1|6 57.02 cM mouse S78-p 456957 RIEPDSEsQEEIIHN BID cell cycle regulation; apoptosis, induced; apoptosis, inhibited 16122425; 16122426; 24767991 6 6 0 -Erbb2 HER2 EC 2.7.10.1; KINASE; Kinase, protein; Membrane protein, integral; Oncoprotein; Protein kinase, TK; Protein kinase, tyrosine (receptor) P06494 24337 10q31 rat Y1250-p 447614 PTAENPEyLGLDVPV molecular association, regulation cell growth, altered EGFR(INDUCES); Chk1(INDUCES) 1354355; 15163624; 9461599 60 15 200 -CREM CREM DNA-binding; Transcription factor Q03060 1390 10p11.21 human S277-p 450066 ASPGSLHsPQQLAEE protein degradation; ubiquitination 11466319 4 12 1 -Elavl4 ELAVL4 RNA-binding O09032 432358 5q35 rat R248-me 478333 PLHHQAQrFRLDNLL cell growth, induced 16508003 1 0 0 -NRAS NRas G protein; G protein, monomeric; G protein, monomeric, Ras; Motility/polarity/chemotaxis; Oncoprotein P01111 4893 1p13.2 human Y32-p 15228782 QNHFVDEyDPTIEDS Ras molecular association, regulation; activity, inhibited RASA1(INDUCES); RALA(INDUCES) 25157176; 26617336 2 4 8 -Myb Myb DNA-binding; Oncoprotein; Transcription factor P06876 17863 10 A3|10 9.75 cM mouse S556-p 1308923 TQLFSQAsPVADAPN protein degradation 18006338 1 0 0 stress-induced degredation -EGLN2 EGLN2 EC 1.14.11.29; Oxidoreductase Q96KS0 112398 19q13.2 human S132-p 4213804 GGDAPSPsKRPWARQ enzymatic activity, inhibited 18710826 1 0 0 -CDC7 CDC7 EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, Other; Protein kinase, Ser/Thr (non-receptor) O00311 8317 1p22.2-p22.1 human T472-p 23092186 LRGMDSStPKLTSDI Pkinase protein degradation; ubiquitination 27611229 1 0 1 -SUMO1 SUMO1 Nuclear receptor co-regulator; Ubiquitin-like modifier P63165 7341 2q33.1 human T76-p 15178384 QRIADNHtPKELGME Rad60-SLD sumoylation; protein stabilization cell growth, induced; transcription, induced 25867063 1 2 0 induces global sumoylation -Arhgef7 ARHGEF7 GEF; GEF, Rac/Rho; Motility/polarity/chemotaxis O55043 114559 16q12.5 rat S71-p 3573357 KPSEKPVsPKSGTLK molecular association, regulation; protein conformation 14-3-3 beta(INDUCES); NEDD4 iso2(INDUCES) 31566435 1 31 0 Regulates ENaC activity -ITGB4 ITGB4 iso2 Cell adhesion; Membrane protein, integral; Motility/polarity/chemotaxis; Receptor, misc. P16144-2 3691 17q25.1 human Y1642-p 450143 GLSENVPyKFKVQAR fn3 molecular association, regulation cell adhesion, altered SHC1(INDUCES) 11044453 1 0 0 -FGF14 FGF14 Cell development/differentiation; Cytokine Q92915 2259 13q33.1 human S230-p 54201600 VTPSKSTsASAIMNG activity, induced; intracellular localization SCN2A(INDUCES); SCN8A(INDUCES) 26917740 1 1 0 axodendritic polarity, FGF14 modulation of Nav mediated currents -RND3 RhoE G protein; G protein, monomeric; G protein, monomeric, Rho; Motility/polarity/chemotaxis P61587 390 2q23.3 human S11-p 455489 RRASQKLsSKSIMDP protein stabilization; intracellular localization 15775972 1 0 0 -KLC2 KLC2 Microtubule-binding; Motor Q9H0B6 64837 11q13.2 human S582-p 452949 PRMKRASsLNFLNKS molecular association, regulation 14-3-3 beta(INDUCES) 21725060 2 75 63 mutation of this site prevents 14-3-3 binding (pan-14-3-3 antibody) -BAZ1B WSTF DNA replication; EC 2.7.10.2; KINASE; Kinase, protein; Nuclear receptor co-regulator; Protein kinase, Ser/Thr (non-receptor); Protein kinase, tyrosine (non-receptor) Q9UIG0 9031 7q11.23 human S158-p 3215310 KSDGACDsPSSDKEN molecular association, regulation; phosphorylation; enzymatic activity, induced carcinogenesis, induced; cell growth, induced; transcription, induced H2AX(INDUCES) 19776015; 32518374 3 14 5 promotes phosphorylation of WSTF at S158 -Ptpn6 SHP-1 EC 3.1.3.48; Motility/polarity/chemotaxis; PHOSPHATASE; Protein phosphatase, tyrosine (non-receptor) P29351 15170 6 F2|6 59.17 cM mouse Y564-p 448912 SKHKEEVyENVHSKS enzymatic activity, induced cell growth, altered 20858858 18 19 776 -TAOK1 TAO1 EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, STE; Protein kinase, Ser/Thr (non-receptor) Q7L7X3 57551 17q11.2 human S990-p 3627517 SRSTSVTsQISNGSH activity, induced cell cycle regulation 17396146 1 0 5 -MKNK1 Mnk1 EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, CAMK; Protein kinase, Ser/Thr (non-receptor); Translation Q9BUB5 8569 1p33 human T250-p 447621 NSCTPITtPELTTPC Pkinase enzymatic activity, induced apoptosis, inhibited; cell growth, altered 17130135; 17590453; 18299328 14 1 1 Disruption of Mnk1 Mnk2 enhances As2O4 inducedapoptosis. -KIT Kit EC 2.7.10.1; KINASE; Kinase, protein; Membrane protein, integral; Oncoprotein; Protein kinase, TK; Protein kinase, tyrosine (receptor) P10721 3815 4q12 human Y568-p 448014 EEINGNNyVYIDPTQ activity, induced; protein degradation; molecular association, regulation; receptor internalization, altered; enzymatic activity, induced; phosphorylation cell growth, altered CTK(INDUCES); Src(INDUCES); APS(INDUCES); SHP-2(INDUCES); CBL(INDUCES) 12444928; 12878163; 16780420; 20147452; 21887372; 9038210; 9528781 13 3 18 -BBC3 PUMA Apoptosis; Mitochondrial Q9BXH1 27113 19q13.32 human S96-p 18610001 RPDGPQPsLSLAEQH PUMA molecular association, regulation; intracellular localization MPC1(INDUCES) 30712844 2 0 0 PUMA interacts with MPC and distrupts the oligomerization of MPC1 and MPC2 -DES desmin Cytoskeletal; Motility/polarity/chemotaxis P17661 1674 2q35 human S60-p 449614 VYQVSRTsGGAGGLG Filament_head intracellular localization cytoskeletal reorganization 12686604 2 7 0 Mutated desmin sites showed failure of desmin filaments to segregate into daughter cells. ; Phosphorylated at the clevage furrow during cytokinesis. -ATG9A ATG9A Autophagy; Membrane protein, integral; Membrane protein, multi-pass; Vesicle Q7Z3C6 79065 2q35 human S14-p 3203970 EYQRLEAsYSDSPPG autophagy, induced 27934868 1 14 16 -Pdcd4 PDCD4 Apoptosis; Tumor suppressor Q61823 18569 19 D2|19 48.73 cM mouse S94-p 472106 SGVAVPTsPKGRLLD translation, inhibited 28644433 1 57 46 -MRNIP MRNIP Unknown function Q6NTE8 51149 5q35.3 human S100-p 57812704 NVKQQEKsQPSESRW MRNIP intracellular localization 27568553 1 0 0 -Ceacam1 CEACAM1 Cell adhesion; Immunoglobulin superfamily; Membrane protein, integral; Motility/polarity/chemotaxis P16573 81613 1q21 rat Y488-p 447777 NKVDDVSySVLNFNA activity, induced 7518458; 7626603 10 2 0 phosphorylation of this site may regulate the kinetics of bile acid efflux activity of CEACAM1; Phosphorylation of CEACAM1 induces Ca2+/Mg2+-dependent ecto ATPase activity. -BCAR1 P130Cas Adaptor/scaffold; Motility/polarity/chemotaxis P56945 9564 16q23.1 human Y165-p 448722 PSPATDLyQVPPGPG activity, induced carcinogenesis, induced; cell motility, induced; cell adhesion, induced; cytoskeletal reorganization 22084245; 34169835 13 1 0 -TTK TTK Cancer Testis Antigen (CTA); EC 2.7.12.1; KINASE; Kinase, protein; Protein kinase, Other; Protein kinase, dual-specificity (non-receptor) P33981 7272 6q14.1 human T458-p 15428764 CKTPSSNtLDDYMSC intracellular localization; enzymatic activity, induced 26119734 1 0 1 regulates spindle assembly checkpoint and recruitment of SAC proteins -OTC OTC Amino Acid Metabolism - arginine and proline; EC 2.1.3.3; Mitochondrial; Transferase P00480 5009 Xp11.4 human K88-ac 467097 SLGMIFEkRSTRTRL OTCace_N enzymatic activity, inhibited 19318352 1 7 30 -HABP4 HABP4 Transcription regulation Q5JVS0 22927 9q22.32 human K276-sm 1873147502 PEEESPAkVPELEVE HABP4_PAI-RBP1 molecular association, regulation 28695742 1 0 0 Presence of SUMO-1 strongly influences the interaction of HABP4 (Ki-1/57) with other cellular proteins.; Fewer PML-nuclear bodies when compared to non-SUMOylated triple mutants, but not when treated with As2O2 -COX5B COX5B EC 1.9.3.1; Energy Metabolism - oxidative phosphorylation; Mitochondrial; Oxidoreductase P00428 cow S33-p 25265505 SVVRSMAsGGGVPTD COX5B enzymatic activity, inhibited 22522801 0 1 0 -NR3C2 MCR DNA-binding; Nuclear receptor P08235 4306 4q31.23 human K953-sm 3144807 FRESHALkVEFPAML transcription, induced; transcription, inhibited 14500761; 17105732 3 0 0 Ubc9 can be a transcriptional mineralocorticoid receptor coactivator. -INSR INSR iso2 EC 2.7.10.1; KINASE; Kinase, protein; Membrane protein, integral; Protein kinase, TK; Protein kinase, tyrosine (receptor) P06213-2 3643 19p13.2 human Y1343-p 447683 SLGFKRSyEEHIPYT activity, inhibited cell cycle regulation 2026614 15 5 2 -NCF1 p47phox EC 1.-.-.-; Oxidoreductase P14598 653361 7q11.23 human S320-p 451726 QRSRKRLsQDAYRRN NECFESHC molecular association, regulation; enzymatic activity, induced signaling pathway regulation CYBA(INDUCES) 12056906; 31736979; 35108370 13 10 8 LPS-induced activation of p38MAPK and ERK1/2 signaling pathways -ACTN4 ACTN4 Cytoskeletal; Motility/polarity/chemotaxis O43707 81 19q13.2 human Y31-p 11498502 GGGSMGDyMAQEDDW molecular association, regulation; intracellular localization; protein conformation; phosphorylation apoptosis, induced; cell motility, inhibited; cytoskeletal reorganization; cell growth, altered ACTA1(DISRUPTS); ACTB(DISRUPTS) 19920151; 26012634; 31664084 5 1 0 -Nrip1 RIP140 Nuclear receptor co-regulator; Transcription, coactivator/corepressor Q8CBD1 268903 16|16 C3.1 mouse K932-ac 459041 RSWARESkSFNVLKQ NRIP1_repr_4 intracellular localization transcription, inhibited 15879431 0 2 0 -Gria4 GluR4 Channel, ligand-gated; Membrane protein, integral; Membrane protein, multi-pass P19493 29629 8q11 rat S862-p 448810 TRNKARLsITGSVGE receptor internalization, altered; intracellular localization 12536214 6 4 1 -MBD4 MBD4 Apoptosis; DNA repair, damage; Deoxyribonuclease; EC 3.2.2.- O95243 8930 3q21.3 human K215-sm 1877787601 TSTHLLLkEDEGVDD DNA repair, induced 31476572 1 1 0 -GLI3 GLI3 C2H2-type zinc finger protein; Transcription factor P10071 2737 7p14.1 human K779-ub 6097712 TKWMEHVkLERLKQV protein processing 16705181 1 0 0 -Grid2 GluR-delta2 Channel, calcium; Channel, ligand-gated; Membrane protein, integral; Membrane protein, multi-pass Q63226 79220 4q31 rat S945-p 3595502 QTLSRTLsAKAASGF molecular association, regulation AIP1(INDUCES) 12589829 3 0 0 -SOX10 SOX10 Cell development/differentiation; DNA-binding; Transcription factor P56693 6663 22q13.1 human S45-p 456247 GGSGLRAsPGPGELG Sox_N protein stabilization 29315345 2 6 0 -Xbp1 XBP1 iso2 DNA-binding; Transcription factor O35426-2 22433 mouse S348-p 1876695603 SPFSDMSsPLGTDHS intracellular localization 34421344 1 0 0 increased S348 phosphorylation increases sumoylation and inhibits nuclear localization -Pard3 PAR3-alpha Adaptor/scaffold; Motility/polarity/chemotaxis Q9Z340 81918 19q12 rat S144-p 455668 PLHVRRSsDPALTGL molecular association, regulation 14-3-3 zeta(INDUCES) 33093242 4 21 26 -SLC6A4 SERT Membrane protein, integral; Membrane protein, multi-pass; Transporter P31645 6532 17q11.2 human T616-p 7576402 IKSITPEtPTEIPCG molecular association, regulation; intracellular localization Vimentin(DISRUPTS) 19270731 2 1 0 -MARK2 MARK2 iso13 EC 2.7.11.1; EC 2.7.11.26; KINASE; Kinase, protein; Protein kinase, CAMK; Protein kinase, Ser/Thr (non-receptor) Q7KZI7-13 2011 11q13.1 human T324-p 4145507 RYNEVMAtYLLLGYK UBA intracellular localization cytoskeletal reorganization; cell growth, altered 18760999 1 0 0 -NOS3 eNOS Amino Acid Metabolism - arginine and proline; EC 1.14.13.39; Oxidoreductase P29473 287024 cow S116-p 448638 RKLQTRPsPGPPPAE molecular association, regulation; enzymatic activity, inhibited; phosphorylation Src(DISRUPTS); Akt1(DISRUPTS) 12050171; 12591925; 23727078 22 4 0 eNOS S115A mutation increases phosphorylation of S1178 by about 50%; dephosphorylation of this site facilitates phosphorylation of Y83 -UBE2R2 UBC3B EC 6.3.2.19; Ligase; UBIQUITIN LIGASE; Ubiquitin conjugating system; Ubiquitin ligase Q712K3 54926 9p13.3 human S233-p 449751 DCYDDDDsGNEES__ molecular association, regulation transcription, altered BRD8 iso2(INDUCES) 12037680 1 1 0 CK2-dependent phosphorylation of UCB3C leads to beta-catenin degredation and inhibition of beta-catenin transcription. -MYBPC3 MYBPC3 Myosin-binding Q14896 4607 11p11.2 human S304-p 471081 SLLKKRDsFRTPRDS cytoskeletal reorganization 20018870 28 6 0 regulation of cardiac myofilament function -RAB7A Rab7 G protein; G protein, monomeric; G protein, monomeric, Rab P51149 7879 3q21.3 human K175-sm 1881818301 TIARNALkQETEVEL protein degradation; molecular association, regulation; enzymatic activity, induced PLEKHM1(DISRUPTS); RILP(DISRUPTS) 30510112 1 1 0 SUMOylation prevents bacterial multiplication and SCV stability, increases its GTPase activity -PIP5K1C PIP5K1C Carbohydrate Metabolism - inositol phosphate; EC 2.7.1.68; Kinase, lipid; Motility/polarity/chemotaxis O60331 23396 19p13.3 human S448-p 17550224 NTVFRKNsSLKSSPS molecular association, regulation; enzymatic activity, inhibited carcinogenesis, altered; cell motility, altered; cell adhesion, induced talin 1(DISRUPTS) 27775029; 30555634 2 1 0 Phosphorylation of PIP5K1C serve as an indicator of aggressiveness of breast tumors -Hsf1 HSF1 DNA-binding; Transcription factor P38532 15499 15 D3|15 35.95 cM mouse S303-p 449045 RVKQEPPsPPHSPRV Vert_HS_TF activity, inhibited transcription, inhibited; transcription, altered 11162511; 28724629 23 59 5 low but significant expression of Hsps under physiological growth conditions and after a mild stress -HLA-DRA HLA-DRA Membrane protein, integral P01903 3122 6p21.32 human K244-ub 6140801 FIIKGLRkSNAAERR intracellular localization 19117940 1 0 0 -ATM ATM DNA repair, damage; EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, Ser/Thr (non-receptor); Protein kinase, atypical; Tumor suppressor Q13315 472 11q22.3 human S1403-p 22496700 CHKTKLKsILEILSK enzymatic activity, induced cell cycle regulation 22099307 1 0 0 phosphorylation of S1403 is required for mitotic activation of ATM; required for the spindle checkpoint activation -MYLK smMLCK EC 2.7.11.18; KINASE; Kinase, protein; Protein kinase, CAMK; Protein kinase, Ser/Thr (non-receptor) P29294 100009143 rabbit S1011-p 468782 SSTGSPTsPLTAERL intracellular localization 12176732 5 22 2 -PHF2 PHF2 DEMETHYLASE; Demethylase; EC 1.14.11.-; Nucleolus O75151 5253 9q22.31 human S1056-p 11138771 FLTQRRPsASSPNNN molecular association, regulation transcription, induced Mrf-2(INDUCES) DNA(INDUCES) 21532585 1 12 7 demethylation of Mrf-2 K336, complex is then targeted to promoters and removes repressive H3K9m2 -CFTR CFTR Channel, chloride; EC 3.6.3.49; Hydrolase; Membrane protein, integral; Membrane protein, multi-pass; Transporter; Transporter, ABC family P13569 1080 7q31.2 human S511-p 477193 ENIIFGVsYDEYRYR ABC_tran activity, induced 17289674 2 0 0 regulates CFTR channel gating -LATS2 LATS2 EC 2.7.11.1; KINASE; Kinase, protein; Nuclear receptor co-regulator; Protein kinase, AGC; Protein kinase, Ser/Thr (non-receptor); Tumor suppressor Q9NRM7 26524 13q12.11 human S408-p 17600400 PVPSRTNsFNSHQPR activity, induced cell cycle regulation; apoptosis, inhibited; signaling pathway regulation 21118956; 30800215 2 5 0 Hippo pathway; in SAS cell line -GPKOW GPKOW RNA-binding Q92917 27238 Xp11.23 human T316-p 21127301 GTASSRKtLWNQELY molecular association, regulation RNA(DISRUPTS) 21880142 1 0 0 regulates pre-mRNA processing -DRD1 DRD1 GPCR, family 1; Membrane protein, integral; Membrane protein, multi-pass; Receptor, GPCR P21728 1812 5q35.2 human T428-p 458339 SVILDYDtDVSLEKI molecular association, regulation signaling pathway regulation G-alpha(s)(INDUCES); ARR3(INDUCES) 32503917 2 0 0 ERK1/2 activation -SNX18 SNX18 Motility/polarity/chemotaxis; Vesicle Q96RF0 112574 5q11.2 human S233-p 7322488 SRNLNRFsTFVKSGG autophagy, inhibited 23878278 1 3 0 -SULT4A1 SULT4A1 EC 2.8.2.-; Transferase Q9BR01 25830 22q13.31 human T11-p 2048305 SEAETPStPGEFESK protein degradation; molecular association, regulation PIN1(INDUCES) 19439498; 20920535 2 4 0 -Lrp1 LRP1 Cell surface; Membrane protein, integral; Motility/polarity/chemotaxis; Receptor, misc. Q91ZX7 16971 10|10 D3 mouse Y4474-p 473712 VEIGNPTyKMYEGGE activity, induced; molecular association, regulation RAB8A(INDUCES) 30208326 4 3 2 -PJA2 PJA2 EC 6.3.2.-; EC 6.3.2.19; Ligase; UBIQUITIN LIGASE; Ubiquitin conjugating system; Ubiquitin ligase O43164 9867 5q21.3 human T389-p 18713701 RVITQREtENNQMTS ubiquitination; enzymatic activity, induced signaling pathway regulation 21423175 1 0 0 S342A/T389A mutant fails to ubiquitylate PKAR2A in vitro -STX17 STX17 Membrane protein, integral; Membrane protein, multi-pass; Vesicle P56962 55014 9q31.1 human S202-p 102898200 SQQEKIDsIADHVNS SNARE intracellular localization autophagy, induced ATG101(INDUCES); RB1CC1(INDUCES) 30827897 1 1 0 assembly of ULK1-ATG13-FIP200 complexes; Localizes to the Golgi; colocalization and association with LC3 -Pag1 PAG Adaptor/scaffold; Membrane protein, integral Q9JM80 64019 2q23 rat Y165-p 454745 GPGVEGPyEVLKDSS PAG cell growth, altered 18498747 1 23 136 -GLI1 GLI1 C2H2-type zinc finger protein; Oncoprotein; Transcription factor P08151 2735 12q13.3 human S243-p 27708601 DCRWDGCsQEFDSQE molecular association, regulation; intracellular localization cell growth, induced; transcription, induced; transcription, inhibited SUFU(INDUCES) DNA(INDUCES); DNA(DISRUPTS) 23446420; 29662197 2 0 0 localized in cytoplasm -G6PD G6PD Carbohydrate Metabolism - pentose phosphate pathway; Cell development/differentiation; EC 1.1.1.49; Other Amino Acids Metabolism - glutathione; Oxidoreductase P11413 2539 Xq28 human Y428-p 7705803 DLTYGNRyKNVKLPD G6PD_C cell motility, altered 19359662 2 1 0 modulates Akt activity -KRT8 K8 Cytoskeletal P05787 3856 12q13.13 human K101-ac 461563 QIKTLNNkFASFIDK Filament cytoskeletal reorganization 18203277 1 4 43 intermediate filament stabilization -KLF1 KLF1 C2H2-type zinc finger protein; DNA-binding; Transcription factor Q13351 10661 19p13.13 human K265-ac 460629 IAETAPSkRGRRSWA activity, induced transcription, induced 9707565 1 0 0 -CYLD CYLD DEUBIQUITINASE; EC 3.4.19.12; Protease; Tumor suppressor; Ubiquitin conjugating system; Ubiquitin-specific protease Q9NQC7 1540 16q12.1 human S436-p 12173907 TNGSIGHsPLSLSAQ CYLD_phos_site ubiquitination 15870263 1 0 0 induces ubiquitination of TRAF2 -LAT LAT iso2 Adaptor/scaffold; Membrane protein, integral O43561-2 27040 16p11.2 human Y171-p 448004 SMESIDDyVNVPESG LAT activity, induced; molecular association, regulation; phosphorylation cell differentiation, altered; cell motility, induced; cell growth, inhibited; cell adhesion, altered; signaling pathway regulation; transcription, altered GRB2(INDUCES); PLCG1(INDUCES); GADS(INDUCES); THEMIS(INDUCES); TSAd(INDUCES) 11395491; 12496416; 15029250; 15100278; 23460737; 27896837; 28699640; 30510001; 34161759; 35124007 24 1 17 induces Erk and calcium signaling; reduces contact times between T cells and dendritic cells -IRF3 IRF3 DNA-binding; Transcription factor Q14653 3661 19q13.33 human K105-ub 1877340003 KDPHDPHkIYEFVNS IRF transcription, induced DNA(INDUCES) 32075857 1 0 0 -FFAR1 FFAR1 GPCR, family 1; Membrane protein, integral; Membrane protein, multi-pass; Receptor, GPCR O14842 2864 19q13.12 human S298-p 25292282 ARTQGGKsQK_____ receptor internalization, induced; intracellular localization; phosphorylation signaling pathway regulation 35065200 1 1 1 induces ERK phosphorylation, induces FFA1 receptor signaling -TTK TTK Cancer Testis Antigen (CTA); EC 2.7.12.1; KINASE; Kinase, protein; Protein kinase, Other; Protein kinase, dual-specificity (non-receptor) P33981 7272 6q14.1 human T453-p 471487 DPKSICKtPSSNTLD protein stabilization; molecular association, regulation CDKN3(INDUCES) 26586430 2 4 9 recruiting Cdkn3 to centrosomes, interaction is required for maintaining the proper number of centrosomes -TNK2 Ack EC 2.7.10.2; EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, TK; Protein kinase, tyrosine (non-receptor) Q07912 10188 3q29 human Y284-p 450946 LPQNDDHyVMQEHRK PK_Tyr_Ser-Thr phosphorylation; enzymatic activity, induced cell cycle regulation; cell growth, induced; apoptosis, inhibited; transcription, induced 16472662; 25148682; 37330596 14 28 235 -Irs1 IRS1 Adaptor/scaffold; Motility/polarity/chemotaxis P35569 16367 1 C5|1 42.0 cM mouse S302-p 450190 TRRSRTEsITATSPA phosphorylation neural plasticity; signaling pathway regulation; cell growth, altered 14623899; 20332342; 32075735 56 12 1 -Syngap1 SynGAP GAP; GAP, Ras F6SEU4 240057 17|17 A3.3 mouse S817-p 33636339 RPPLARSsPAYCTSS DUF3498 activity, induced 25533468 1 1 2 S817D mutation increases Rap2 GAP , rap1 GAP and HRas GAP activities of SynGAP -PFN1 profilin 1 Actin-binding; Cytoskeletal; Motility/polarity/chemotaxis P07737 5216 17p13.2 human Y129-p 450514 GLINKKCyEMASHLR Profilin protein stabilization; molecular association, regulation carcinogenesis, induced; cell growth, induced; transcription, induced VHL(INDUCES) 24747440 4 25 658 prevents degradation of HIF-1a -TOP1 TOP1 EC 5.99.1.2; Isomerase; Nucleolus; Oncoprotein P11387 7150 20q12 human K117-sm 2793907 FSSPPQIkDEPEDDG molecular association, regulation; intracellular localization apoptosis, induced DNA(INDUCES) 12149243; 12439742 4 5 0 increase in CPT-induced apoptosis; enhances TOPO1-DNA cleavable complex formation induced by CPT -Myl12b MRLC2 Contractile Q3THE2 67938 17|17 E1.3 mouse S2-p 448593 ______MsSKKAKTK cytoskeletal reorganization; cell adhesion, altered 17928407 1 0 0 induced disassembly of stress fibers and decreased large focal adhesions -SLK SLK EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, STE; Protein kinase, Ser/Thr (non-receptor) Q9H2G2 9748 10q24.33-q25.1 human T183-p 1211366 VSAKNTRtIQRRDSF Pkinase molecular association, regulation; phosphorylation; enzymatic activity, induced apoptosis, induced SLK(INDUCES) 22203681; 28475647 2 13 27 induces phosphorylation of JNK and p38, homodimerization induces kinase activity -Mapk3 ERK1 EC 2.7.11.24; KINASE; Kinase, protein; Protein kinase, CMGC; Protein kinase, Ser/Thr (non-receptor) Q63844 26417 7 F3|7 69.25 cM mouse T203-p 447542 HDHTGFLtEYVATRW Pkinase intracellular localization; enzymatic activity, induced cell cycle regulation; carcinogenesis, induced; carcinogenesis, inhibited; apoptosis, induced; cell motility, induced; cell growth, inhibited; cell motility, inhibited; transcription, induced; signaling pathway regulation; transcription, altered; neural plasticity; cell growth, induced; apoptosis, inhibited; cytoskeletal reorganization; transcription, inhibited 10867029; 11934884; 12446705; 1518847; 15788406; 15975986; 19004831; 21562256; 21706057; 21813649; 21887248; 21917714; 25584415; 34118691; 34191798; 34520454; 34617326; 35085550; 35857631; 36070687; 36088505; 36310322; 36736425; 37160873; 37430253 1343 110 2017 -Nfat5 NFAT5 Transcription factor Q9WV30 54446 8 D3|8 53.93 cM mouse Y143-p 12127405 PKRHTVLyISPPPED molecular association, regulation transcription, inhibited TAZ(INDUCES) 23045390 5 1 0 Y316 TAZ negatively regulates SL6A12 and SLC5A3 gene expression; luciferase reporter -SEPTIN9 SEPT9 Cell cycle regulation; Cytoskeletal; Hydrolase Q9UHD8 10801 17q25.3 human S30-p 453398 SGPALKRsFEVEEVE apoptosis, induced; cell adhesion, induced 25944883 1 73 26 -KHDRBS1 KHDRBS1 RNA-binding Q07666 10657 1p35.2 human R310-m1 476771 GRGVGPPrGALVRGT intracellular localization 12529443 1 4 19 -EEF2 EEF2 Translation; Translation elongation P55823 rabbit T56-p 448040 RAGETRFtDTRKDEQ GTP_EFTU activity, inhibited 8386634 39 61 54 -MAVS MAVS Adaptor/scaffold; Membrane protein, integral Q7Z434 57506 20p13 human K10-ub 89115600 FAEDKTYkYICRNFS CARD_2 molecular association, regulation MAVS(INDUCES) 27992402 1 0 0 -FERMT1 kindlin-1 Cytoskeletal; Motility/polarity/chemotaxis Q9BQL6 55612 20p12.3 human S179-p 2508995 TASGSSVsPGLYSKT protein degradation cell cycle regulation; cell growth, induced; apoptosis, inhibited; cytoskeletal reorganization; cell adhesion, inhibited 35469017 1 6 0 -Sf1 SF1 RNA splicing; RNA-binding; Spliceosome; Transcription, coactivator/corepressor NP_001104263 117855 1q43 rat S20-p 449919 PSKKRKRsRWNQDTM SF1-HH molecular association, regulation RNA splicing, altered U2AF2(DISRUPTS) 10449420 2 3 0 -Fmr1 FMR1 Nucleolus; RNA-binding; Translation P35922 14265 X A7.1|X 34.83 cM mouse R538-me 4046003 RRRRGGGrGQGGRGR FXMRP1_C_core molecular association, regulation RNA(DISRUPTS) 20064924 2 0 0 methylation inhibits sc1 RNA binding; R533 and R538 determine association with polyribosomes; methylation doesnot inhibit AATYK mRNA association; different RNAs have distinct molecular requirements for binding to FMR1 -Grin1 NMDAR1 Channel, calcium; Channel, ligand-gated; Membrane protein, integral; Membrane protein, multi-pass P35439 24408 3p13 rat S897-p 448256 SFKRRRSsKDTSTGG receptor desensitization, inhibited; molecular association, regulation; receptor inactivation, inhibited Calmodulin(DISRUPTS) 24847051; 9252405 27 0 0 -Ulk1 ULK1 Autophagy; EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, Other; Protein kinase, Ser/Thr (non-receptor) O70405 22241 5|5 F mouse S467-p 483136 SAIRRSGsTTPLGFG autophagy, altered 21205641 3 21 4 -ROCK1 ROCK1 EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, AGC; Protein kinase, Ser/Thr (non-receptor) Q13464 6093 18q11.1 human T1337-p 18261228 RTLSTRStANQSFRK intracellular localization cytoskeletal reorganization 21685893 1 3 2 inhibits apical constriction -ADRA1D ADRA1D GPCR, family 1; Membrane protein, integral; Membrane protein, multi-pass; Receptor, GPCR P25100 146 20p13 human S332-p 1424270006 KGHTFRSsLSVRLLK 7tm_1 receptor internalization, altered signaling pathway regulation 29551601 1 1 0 regulates ERK signaling pathway, induces calcium signaling de-sensitization -TCF7L2 TCF7L2 Apoptosis; Cell cycle regulation; Cell development/differentiation; DNA-binding; Motility/polarity/chemotaxis; Transcription factor Q9NQB0 6934 10q25.2-q25.3 human S177-p 14918200 QALKDARsPSPAHIV CTNNB1_binding transcription, induced 20530691 1 9 0 -WWOX WWOX Apoptosis; EC 1.1.1.-; Oxidoreductase; Tumor suppressor Q9NZC7 51741 16q23.1-q23.2 human K274-ub 21188582 DINDSLGkLDFSRLS protein stabilization; molecular association, regulation cell cycle regulation; DNA repair, induced ATM(INDUCES) 26675548 1 3 0 G2/M phase checkpoint activation, maintains genomic stability -Lck Lck EC 2.7.10.2; KINASE; Kinase, protein; Oncoprotein; Protein kinase, TK; Protein kinase, tyrosine (non-receptor) P06240 16818 4 D2.2|4 63.26 cM mouse Y505-p 447823 FTATEGQyQPQP___ protein stabilization; intracellular localization; enzymatic activity, inhibited; phosphorylation cell differentiation, inhibited; cell cycle regulation; carcinogenesis, induced; apoptosis, altered; cell growth, inhibited; signaling pathway regulation 14749125; 15199125; 15699109; 17719247; 33420490; 33684096; 35638332; 36376335; 8413300 57 32 805 inhibits phosphorylation of PLCG1, LAT and ZAP70; inhibits phosphorylation of ZAP70, ERK, and translocation of NFATc2, inhibits ERK signaling -Kcnj12 KCNJ12 Membrane protein, integral; Membrane protein, multi-pass P52188 117052 10q22 rat S425-p 2150913 ERPYRREsEI_____ molecular association, regulation DLG1(DISRUPTS) 11181181 1 0 0 -Atoh1 ATOH1 Cell development/differentiation; DNA-binding; Transcription factor P48985 11921 6 C1|6 30.03 cM mouse S193-p 149314900 FNNDKKLsKYETLQM HLH cell motility, inhibited 28729444 1 0 0 193A mutant has a neuronal progenitor migration defect, motor coordination deficits and cerebellar foliation defects, mutant mice are deaf and lose inner ear hair cells -FH fumarase iso2 Carbohydrate Metabolism - citrate (TCA) cycle; EC 4.2.1.2; Lyase; Mitochondrial; Tumor suppressor P07954-2 2271 1q43 human S128-p 31878710 MLGGELGsKIPVHPN Lyase_1 intracellular localization; enzymatic activity, inhibited 33058874 1 2 0 -SIRT7 SIRT7 DEACETYLASE; Deacetylase; EC 3.5.1.-; Nucleolus Q9NRC8 51547 17q25.3 human T153-p 125108501 TLTHMSItRLHEQKL SIR2 activity, induced; protein degradation; molecular association, regulation; intracellular localization transcription, inhibited REG3G(INDUCES) 27511885; 28582407 2 0 0 inhibits rDNA transcription, saves energy to maintain cell survival -Rrad RRAD G protein; G protein, monomeric; G protein, monomeric, RGK NP_445790 83521 19p14 rat S272-p 457396 AGTRRREsLGKKAKR activity, induced 36215501 4 1 0 induces CaV1.2 activity -Rnf31 RNF31 EC 6.3.2.-; EC 6.3.2.19; Ligase; UBIQUITIN LIGASE; Ubiquitin conjugating system; Ubiquitin ligase Q924T7 268749 14|14 C3 mouse K1050-ub 21183662 YQARLLQkLREEVPL enzymatic activity, inhibited; protein conformation transcription, inhibited 26578682 1 5 0 negatively regulates NF-kB activation induced by bacterial LPS-mediated TLR4 stimulation -PTPN11 SHP-2 iso1 EC 3.1.3.48; Motility/polarity/chemotaxis; PHOSPHATASE; Protein phosphatase, tyrosine (non-receptor) Q06124-1 5781 12q24.13 human Y546-p 448492 SKRKGHEyTNIKYSL molecular association, regulation; enzymatic activity, induced GAB2(INDUCES) 23980151 38 25 442 -Smarca2 SMARCA2 EC 3.6.1.-; EC 3.6.4.-; Helicase; Nuclear receptor co-regulator; Transcription, coactivator/corepressor Q6DIC0 67155 19 C1|19 21.17 cM mouse K1551-ac 460624 RPNRGKAkPVVSDFD molecular association, regulation; protein conformation cell growth, induced; transcription, inhibited Rb(DISRUPTS) DNA(DISRUPTS) 14657023 1 0 0 -SNAI2 Snail2 Apoptosis; C2H2-type zinc finger protein; Motility/polarity/chemotaxis; Transcription factor O43623 6591 8q11.21 human K166-ac 59171804 FSCKYCDkEYVSLGA zf-C2H2 protein stabilization cell motility, induced 32737855 2 2 0 promotes breast cancer cell EMT and migration -Rb1 Rb Nuclear receptor co-regulator; Oncoprotein; Transcription, coactivator/corepressor; Tumor suppressor P13405 19645 14 38.73 cM|14 D3 mouse S804-p 448717 IYISPLKsPYKISEG Rb_C molecular association, regulation; protein conformation; phosphorylation cell cycle regulation; carcinogenesis, induced; transcription, induced; transcription, altered; chromatin organization, altered; cell growth, induced; apoptosis, inhibited; DNA repair, inhibited; transcription, inhibited; cell growth, altered E2F1(DISRUPTS); SUV420H1(DISRUPTS); SUV420H2(DISRUPTS) 10207050; 1565466; 19217427; 32086342; 33826903; 35023164; 35947949; 9671466 96 40 80 transcriptional downregulation of the E2F-1, E2F-2, dihydrofolate reductase, thymidine kinase, c-myc, proliferating-cell nuclear antigen, p107, and p21/Cip1 genes -GCM1 GCM1 DNA-binding; Transcription factor Q9NP62 8521 6p12.1 human S322-p 7979600 NYPFPLTsWPCSFSP protein degradation; acetylation; molecular association, regulation; ubiquitination transcription, inhibited FBXW2(INDUCES) 19416964; 20855292 2 0 0 inhibits acetylation -GLI3 GLI3 C2H2-type zinc finger protein; Transcription factor P10071 2737 7p14.1 human K595-m1 56418601 SNASDRAkHQNRTHS zf-C2H2 molecular association, regulation cell growth, induced DNA(INDUCES) 27146893 1 1 0 positively regulates tumorigenesis in NSCLCs -Yy1 YY1 C2H2-type zinc finger protein; Cell development/differentiation; Transcription factor Q8CHJ4 24919 6q32 rat S117-p 460025 EVVGGDDsDGLRAED molecular association, regulation cell growth, induced; transcription, altered ZKSCAN4(INDUCES) DNA(INDUCES) 34747636 3 34 0 -RET Ret EC 2.7.10.1; KINASE; Kinase, protein; Membrane protein, integral; Oncoprotein; Protein kinase, TK; Protein kinase, tyrosine (receptor) P07949 5979 10q11.21 human Y1096-p 449891 RYPNDSVyANWMLSP molecular association, regulation GRB2(INDUCES); PIK3R1(INDUCES) 10995764; 15677445 7 2 3 -Pin1 PIN1 EC 5.2.1.8; Isomerase; Nuclear receptor co-regulator Q9QUR7 23988 9 A3|9 7.6 cM mouse S73-p 18710000 HSQSRRPsSWRQEKI Rotamase enzymatic activity, inhibited; phosphorylation 35002518 6 1 0 induces Tau hyperphosphorylation -Vangl2 VANGL2 Adaptor/scaffold; Membrane protein, integral; Membrane protein, multi-pass Q91ZD4 93840 1 H3|1 79.54 cM mouse S464-p 18507000 AKQWTLVsEEPVTNG Strabismus protein stabilization 21316586 1 0 0 -Slc24a4 SLC24A4 Membrane protein, integral; Membrane protein, multi-pass; Transporter; Transporter, SLC family Q8CGQ8 238384 12|12 E mouse T331-p 29674703 AGLRIMItNKFGPRT activity, induced 24224486 1 0 0 T312A reduced the stimulatory effect of ATP by 50%. -Arnt ARNT DNA-binding; Motility/polarity/chemotaxis; Transcription factor P53762 11863 3 F2.1|3 40.74 cM mouse K245-sm 2293714 DLKTGTVkKEGQQSS PAS molecular association, regulation transcription, inhibited PML(DISRUPTS) 12354770 1 0 0 -RAD51 RAD51 DNA repair, damage; Mitochondrial Q06609 5888 15q15.1 human T13-p 23305002 QLEANADtSVEEESF molecular association, regulation; intracellular localization DNA repair, induced NBS1(INDUCES); BRCA2(INDUCES) 22325354; 24835992 2 1 0 involved in DNA damage recognition and homologous recombination (HR) repair -RBL2 Rb-like 2 Transcription, coactivator/corepressor; Tumor suppressor Q08999 5934 16q12.2 human S662-p 449728 GLGRSITsPTTLYDR molecular association, regulation cell cycle regulation E2F4(DISRUPTS) 11157749; 12006580 3 14 3 -Ciz1 CIZ1 Cell cycle regulation Q8VEH2 68379 2|2 B mouse T192-p 22648005 ARTPSSTtPNRKDSS molecular association, regulation; activity, inhibited cell cycle regulation CCNA1(DISRUPTS) 15585571; 25736292 2 0 0 phosphorylation of T293 and T192, T144 are required for interaction with the cyclinA-CDK2 complex and directing it to chromatin; DNA replication -Mpl MPL Membrane protein, integral; Receptor, cytokine Q08351 17480 4 D2.1|4 54.61 cM mouse Y616-p 450267 THIANHSyLPLSYWQ activity, induced; phosphorylation cell differentiation, altered; transcription, altered; cell growth, altered SHC1(INDUCES) 10803464; 14726379; 19996410; 8978680 11 1 1 TPO induced differentiation requires C-terminal, Y616-p. -BLM BLM DNA repair, damage; DNA replication; EC 3.6.4.12; Helicase P54132 641 15q26.1 human T99-p 450958 NAPAGQEtQRGGSKS BLM_N molecular association, regulation cell cycle regulation; apoptosis, inhibited H2AX(INDUCES); PML(DISRUPTS); TOP3A(DISRUPTS) 12034743; 14729972; 16199871 6 0 0 In cells expressing BLM T99A/T122A after HU release, entrance into G1 phase was delayed, with p-Chk-1 levels remaining elevated. ; radiosensitivity -Gata1 GATA1 DNA-binding; Transcription factor P17679 14460 X A1.1|X 3.59 cM mouse K312-ac 459079 RNRKASGkGKKKRGS protein degradation; acetylation; ubiquitination; phosphorylation cell differentiation, induced DNA(INDUCES) 10207073; 16858405 6 1 0 -SHC4 SHC4 Adaptor/scaffold Q6S5L8 399694 15q21.1 human Y413-p 63044905 IQCEKLCyLPGNSKC molecular association, regulation SHP-2(INDUCES) 28213521 1 1 0 -YWHAZ 14-3-3 zeta Adaptor/scaffold; Motility/polarity/chemotaxis P63104 7534 8q22.3 human T232-p 449846 LTLWTSDtQGDEAEA molecular association, regulation; protein conformation; activity, inhibited 14-3-3 zeta(DISRUPTS); RAF1(DISRUPTS); Tau iso3(DISRUPTS); HSP20(DISRUPTS) 14613942; 15119949; 18559254; 21081103; 9360956 7 12 26 -Srebf1 SREBP-1 iso1 DNA-binding; Membrane protein, integral; Membrane protein, multi-pass; Transcription factor P56720-1 78968 10q22 rat S73-p 14580856 KVTPAPLsPPPSAPT protein degradation; molecular association, regulation; ubiquitination transcription, inhibited SCAP(DISRUPTS) 26589965 1 10 0 -KRT8 K8 Cytoskeletal P05787 3856 12q13.13 human S74-p 448539 TVNQSLLsPLVLEVD Keratin_2_head protein stabilization; molecular association, regulation; ubiquitination; intracellular localization carcinogenesis, inhibited; cell growth, inhibited; apoptosis, induced; cell motility, altered; cell motility, inhibited; cytoskeletal reorganization JNK1(INDUCES); P38A(INDUCES) 10623656; 11781324; 11788583; 15368451; 15707998; 15972820; 17535969; 18617517; 19115206; 19246484; 22114688; 31427430; 32365802 29 8 9 induces solubility of keratin filaments and inhibits polymerization -FANCD2 FANCD2 DNA repair, damage Q9BXW9 2177 3p25.3 human T596-p 460935 RSESPSLtQERANLS FancD2 activity, induced; molecular association, regulation; ubiquitination; intracellular localization signaling pathway regulation DNA(INDUCES) 37392383 2 3 9 regulates the FA pathway -FGFR1 FGFR1 EC 2.7.10.1; KINASE; Kinase, protein; Membrane protein, integral; Oncoprotein; Protein kinase, TK; Protein kinase, tyrosine (receptor) P11362 2260 8p11.23 human S777-p 2721300 SMPLDQYsPSFPDTR intracellular localization cell growth, inhibited; cell motility, inhibited 18411303; 23405013 4 1 0 in DRG neurons axon length was increased in neurons overexpresing the S777A mutant. -P2rx1 P2X1 Channel, ligand-gated; Membrane protein, integral; Membrane protein, multi-pass P51576 18436 11 B4|11 45.09 cM mouse S387-p 26392105 ERDPAATsSTLGLQE carcinogenesis, induced; cell growth, induced 36418376 2 1 0 -SOX9 SOX9 DNA-binding; Transcription factor P48436 6662 17q24.3 human S64-p 451039 EPDLKKEsEEDKFPV Sox_N molecular association, regulation; intracellular localization KPNB1(INDUCES) 15889150 6 0 0 -Prkaa1 AMPKA1 Autophagy; EC 2.7.11.1; EC 2.7.11.26; EC 2.7.11.27; EC 2.7.11.31; KINASE; Kinase, protein; Protein kinase, CAMK; Protein kinase, Ser/Thr (non-receptor) P54645 65248 2q16 rat S496-p 450431 ATPQRSGsISNYRSC AdenylateSensor activity, induced; enzymatic activity, inhibited cell cycle regulation; transcription, induced; signaling pathway regulation 16340011; 17023420; 17032173; 35863470 19 46 55 regulates the AMPK-SIRT3 pathway -PML PML Nucleolus; Oncoprotein; SUMO LIGASE; SUMO conjugating system; SUMO ligase; Transcription factor; Tumor suppressor; Ubiquitin conjugating system P29590 5371 15q24.1 human K487-sm 2793912 SQTQCPRkVIKMESE DUF3583 intracellular localization transcription, induced 23542129; 9885291 2 0 0 -Tfeb TFEB DNA-binding; Transcription factor Q9R210 21425 17 C|17 23.99 cM mouse S462-p 4785132 PEASKASsRRSSFSM DUF3371 protein stabilization; intracellular localization autophagy, induced; transcription, induced 23599343; 35686465 2 3 0 -SHMT1 SHMT1 Amino Acid Metabolism - glycine, serine and threonine; Cofactor and Vitamin Metabolism - one carbon pool by folate; EC 2.1.2.1; Energy Metabolism - methane; Lyase; METHYLTRANSFERASE; Methyltransferase; Mitochondrial; Other Amino Acids Metabolism - cyanoamino acid P34896 6470 17p11.2 human K39-sm 12004407 EVYNIIKkESNRQRV SHMT intracellular localization 17446168 1 0 0 -Dyrk1a DYRK1A EC 2.7.12.2; KINASE; Kinase, protein; Protein kinase, CMGC; Protein kinase, dual-specificity (non-receptor) Q61214 13548 16 C4|16 55.3 cM mouse Y147-p 463250 YDDDNYDyIVKNGEK intracellular localization cell cycle regulation; cell differentiation, altered 21878370 1 2 18 -Il6st gp130 Membrane protein, integral; Receptor, cytokine Q00560 16195 13 D2.2|13 63.73 cM mouse Y757-p 448181 STASTVQySTVVHSG activity, induced; molecular association, regulation; phosphorylation signaling pathway regulation; transcription, altered SOCS3(INDUCES); SHP-2(INDUCES) 12070777; 12593670; 36947594 14 1 2 protection from bacterial infection, promotes increases in IFN-gamma levels; SHP-2 phosphorylation; regulates Src and MAPK/ERK signaling -Mapt Tau ACETYLTRANSFERASE; Acetyltransferase; Cytoskeletal P19332 29477 10q32.1 rat S727-p 454127 SNVSSTGsIDMVDSP neural plasticity 33768378; 33797746 8 13 0 -FERMT1 kindlin-1 Cytoskeletal; Motility/polarity/chemotaxis Q9BQL6 55612 20p12.3 human S176-p 31869918 SSPTASGsSVSPGLY protein degradation cell cycle regulation; cell growth, induced; apoptosis, inhibited; cytoskeletal reorganization; cell adhesion, inhibited 35469017 1 2 0 -WRN WRN Cell cycle regulation; DNA repair, damage; DNA-binding; EC 3.6.4.12; Helicase; Nucleolus Q14191 7486 8p12 human K1117-ac 14512101 YSYKPCDkISSGSNI protein stabilization; ubiquitination 20428248 1 1 0 inhibits ubiquitination -Cysltr1 CYSLTR1 GPCR, family 1; Membrane protein, integral; Membrane protein, multi-pass; Receptor, GPCR Q99JA4 58861 X|X D mouse T151-p 27717317 VQNINLVtQKKARFV 7tm_1 receptor desensitization, induced 23485744 1 0 0 -KCND2 Kv4.2 Channel, potassium; Membrane protein, integral; Membrane protein, multi-pass Q9NZV8 3751 7q31.31 human K579-sm 1879723001 SRSSLNAkMEECVKL endocytosis, inhibited 34795560 2 0 0 ~37?70% increase in channel surface expression and IA Gmax, 65 %reduction in ternary complexes internalization with KChIP2a and DPP10c -PROX1 PROX1 DNA-binding; Nuclear receptor co-regulator; Transcription factor Q92786 5629 1q32.3 human K556-sm 6124707 GLSLSLIkSECGDLQ molecular association, regulation; intracellular localization cell growth, induced; transcription, induced HDAC3(DISRUPTS) DNA(INDUCES) 18948102; 19706680 2 0 0 induces lymphangiogenesis; Sumoylation downregulates the corepressor activity of Prox1 and reduces its recruitment of HDAC3. -EGFR EGFR EC 2.7.10.1; KINASE; Kinase, protein; Membrane protein, integral; Oncoprotein; Protein kinase, TK; Protein kinase, tyrosine (receptor) P00533 1956 7p11.2 human T1041-p 3178896 LLSSLSAtSNNSTVA receptor internalization, induced; protein degradation 24797263 2 4 0 -CENPT CENPT DNA replication F1NPG5 chicken S88-p 27528600 IQNQPQVsPLALQTV CENP-T_N molecular association, regulation SPC25(INDUCES); SPBC24(INDUCES) 23334297 1 0 0 -INSIG1 INSIG1 Membrane protein, integral; Membrane protein, multi-pass O15503 3638 7q36.3 human K156-ub 486340 SHLGEPHkFKREWAS INSIG protein degradation 16399501; 16549805 2 0 0 INSIG1 is degraded more rapidly than INSIG2 which controlled by serine residues flanking the ubiquitination sites in both proteins. -Eif2b5 eIF2B-epsilon Translation; Translation initiation Q64350 192234 11q23 rat S535-p 449905 VDPEELDsRAGSPQL translation, altered; cytoskeletal reorganization; signaling pathway regulation; translation, inhibited; cell growth, altered 15001529; 22231169 10 3 0 -CREB1 CREB DNA-binding; Transcription factor P16220 1385 2q33.3 human S107-p 451811 SVDSVTDsQKRREIL pKID molecular association, regulation; activity, inhibited transcription, inhibited CBP(DISRUPTS) 15073328; 17209043 12 0 0 -JUN Jun Oncoprotein; Transcription factor P05412 3725 1p32.1 human T91-p 450448 SNGHITTtPTPTQFL Jun molecular association, regulation; activity, inhibited transcription, inhibited; transcription, altered MBD3(DISRUPTS); TCF4(DISRUPTS) DNA(DISRUPTS) 12853483; 36253406; 7744008 8 2 0 -STK4 MST1 Autophagy; EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, STE; Protein kinase, Ser/Thr (non-receptor) Q13043 6789 20q13.12 human K59-m2 63128907 TGQIVAIkQVPVESD Pkinase enzymatic activity, inhibited 28114269 1 1 0 -Tomm70a TOMM70A Membrane protein, integral; Mitochondrial; Receptor, protein translocating Q9CZW5 28185 16 C1.1|16 34.22 cM mouse S94-p 1983231 KTPEGRAsPALGSGH O-GlcNAc glycosylation; intracellular localization 33592173 1 89 2 inhibits MIC19 nuclear import -NFE2 NF-E2 Cytoskeletal; DNA-binding; Transcription factor Q16621 4778 12q13.13 human K137-ub 11489903 GLPAGPPkPQEDPES protein degradation; ubiquitination transcription, inhibited 19966288 1 0 0 -DNM1L DRP1 Apoptosis; EC 3.6.5.5; Endoplasmic reticulum; Hydrolase; Microtubule-binding; Mitochondrial; Motor O00429 10059 12p11.21 human K535-sm 9859921 VSRDKSSkVPSALAP activity, induced; intracellular localization 19638400 1 0 0 sumoylation is linked to its GTPase activity cycle, and influenced by DRP1 localization -Kcnb1 Kv2.1 Channel, cation; Channel, ligand-gated; Channel, potassium; Membrane protein, integral; Membrane protein, multi-pass Q03717 16500 2 H3|2 87.22 cM mouse Y690-p 22874701 LLPALGLyHDPLRNR apoptosis, induced 33333928 2 2 2 -GPBAR1 GPBAR1 GPCR, family 1; Membrane protein, integral; Membrane protein, multi-pass; Receptor, GPCR Q8TDU6 151306 2q35 human S323-p 1877729204 AYHPSSQsSVDLDLN molecular association, regulation cell growth, induced; apoptosis, inhibited ARRB1(INDUCES) 35858343 0 1 0 -PRMT1 PRMT1 EC 2.1.1.125; METHYLTRANSFERASE; Methyltransferase; Methyltransferase, protein arginine; Nuclear receptor co-regulator Q99873 3276 19q13.33 human Y309-p 454762 STSPESPyTHWKQTV molecular association, regulation; intracellular localization; enzymatic activity, induced carcinogenesis, induced; cell growth, induced; signaling pathway regulation hnRNP A3(DISRUPTS); hnRNP A1(DISRUPTS) 24358983; 36995937 2 15 126 induces mTOR signaling -TP53 p53 Activator; DNA-binding; Motility/polarity/chemotaxis; Nuclear receptor co-regulator; Transcription factor; Tumor suppressor P04637 7157 17p13.1 human K373-m2 13906423 SSHLKSKkGQSTSRH carcinogenesis, induced; apoptosis, inhibited 20118233 1 0 0 -Mlxipl ChREBP Transcription factor Q99MZ3 58805 5|5 G2 mouse S839-gl 89115102 RQLSTSTsILTDPSL molecular association, regulation; intracellular localization; protein conformation transcription, induced DNA(INDUCES) 28450420 1 0 0 assist translocation of ChREBP from nucleus to cytoplasm -MDM2 MDM2 EC 6.3.2.-; EC 6.3.2.19; Inhibitor; Ligase; NEDDYLATION LIGASE; Neddylation Ligase; Nucleolus; Oncoprotein; UBIQUITIN LIGASE; Ubiquitin conjugating system; Ubiquitin ligase Q00987 4193 12q15 human S425-p 11956708 ETQDKEEsVESSLPL molecular association, regulation; enzymatic activity, inhibited; protein conformation p53(DISRUPTS) 21986495 1 2 0 oligomerization inhibited -GOLGA2 GM130 Cytoskeletal Q08379 2801 9q34.11 human S37-p 454438 REYQQRNsPGVPTGA molecular association, regulation KPNA1(INDUCES); TAP(DISRUPTS) 26165940; 9753325 4 18 1 -NUP62 NUP62 Adaptor/scaffold; Nucleoporin P37198 23636 19q13.33 human S272-p 36440511 SGTSTTTsTAATATA protein degradation; phosphorylation signaling pathway regulation 30401435 1 0 0 induces phosphorylation of IRS1, regulates p38?/p62/mTORC1 pathway -CDK11A CDK11A iso10 Cell cycle regulation; EC 2.7.11.22; KINASE; Kinase, protein; Motility/polarity/chemotaxis; Protein kinase, CMGC; Protein kinase, Ser/Thr (non-receptor); RNA processing Q9UQ88-10 728642 1p36.33 human T370-p 35521302 KHEYFREtPLPIDPS enzymatic activity, induced carcinogenesis, inhibited; cell adhesion, altered; transcription, inhibited; signaling pathway regulation 25106495; 26470709 2 1 0 inhibited the VEGF promoter activity, inhibits angiogenesis; breast cancer metastasis inhibited, integrin B3 promoter activity inhibited, ERalpha protein levels repressed; inhibiting the invasion of breast cancer cells -MYC Myc DNA-binding; Nucleolus; Oncoprotein; Transcription factor P01106 4609 8q24.21 human T73-p 448496 KKFELLPtPPLSPSR Myc_N protein degradation; protein stabilization; molecular association, regulation; ubiquitination; intracellular localization; protein conformation; phosphorylation cell cycle regulation; carcinogenesis, induced; carcinogenesis, inhibited; cell growth, inhibited; apoptosis, induced; transcription, induced; transcription, altered; cell differentiation, altered; autophagy, induced; cell growth, induced; DNA repair, inhibited; transcription, inhibited; cell growth, altered FBXW7(INDUCES); SH2BP1(INDUCES); OTUD6A(INDUCES); CDC73(INDUCES); AurA(INDUCES); PIN1(INDUCES); TUBA4A(DISRUPTS); FBXW7(DISRUPTS) DNA(DISRUPTS) 10706881; 10713166; 10866684; 11018017; 11877389; 11904304; 14563837; 15103331; 15150404; 15673569; 16452238; 17634226; 18408012; 19028839; 19131971; 21441954; 21808024; 22025562; 23318434; 23716601; 24030976; 24998853; 25944903; 26687678; 27213815; 27239040; 27795300; 33461590; 33520979; 33541412; 33627622; 34504649; 35089787; 35217790; 35619182; 36012403; 36718632; 36719686; 37400551; 37495110; 37656618; 8386367 83 40 30 -SRF SRF Motility/polarity/chemotaxis; Transcription factor P11831 6722 6p21.1 human S103-p 447692 RGLKRSLsEMEIGMV molecular association, regulation transcription, altered DNA(INDUCES) 11859076; 1547771; 23548149; 8413226 14 3 5 -CDC37 CDC37 Chaperone Q16543 11140 19p13.2 human S13-p 450034 VWDHIEVsDDEDETH CDC37_N molecular association, regulation HSP90A(INDUCES); HRI(INDUCES) 12930845; 27105117 13 29 0 S13 phosphorylation does not impact recognition or affnity for BRAF. S13 affects chaperone cycle at a stage later than Cdc37 recognition. -Rasgrf1 RASGRF1 GEF; GEF, Ras P28818 192213 8q31 rat S760-p 18710206 LASLGCPsDGYTNIH protein degradation 21382555 1 1 0 -SRF SRF Motility/polarity/chemotaxis; Transcription factor P11831 6722 6p21.1 human K147-sm 2303901 TRGRVKIkMEFIDNK transcription, inhibited 12788062 1 0 0 -PGK1 PGK1 Carbohydrate Metabolism - glycolysis and gluconeogenesis; EC 2.7.2.3; KINASE; Kinase, other P00558 5230 Xq21.1 human S256-p 23131090 NNMEIGTsLFDEEGA PGK molecular association, regulation carcinogenesis, induced; cell growth, induced CDC7(INDUCES) 30392930 1 0 3 -RCOR1 RCOR1 Nuclear receptor co-regulator; Transcription, coactivator/corepressor Q9UKL0 23186 14q32.31-q32.32 human K297-sm 4645800 TETVPQVkKEKHSTQ transcription, inhibited 18854179 1 1 0 -Bad BAD Apoptosis Q61337 12015 19|19 A mouse S112-p 447860 ETRSRHSsYPAGTEE Bcl-2_BAD activity, induced; molecular association, regulation; intracellular localization apoptosis, altered; apoptosis, inhibited Bcl-xL(NOT_REPORTED); JNK1(DISRUPTS); 14-3-3 epsilon(INDUCES); PKACA(INDUCES); 14-3-3 beta(NOT_REPORTED); 14-3-3 beta(INDUCES); PPP2CA(INDUCES); Bcl-2(DISRUPTS); PKCA(INDUCES); Bcl-xL(DISRUPTS) 10230394; 10521512; 10574959; 10611223; 10777478; 10837486; 10887134; 10996800; 11583580; 11717309; 11983683; 12897128; 12944463; 12954615; 14670836; 15123689; 15280015; 15849194; 16009721; 16103085; 19217411; 19915011; 22103330; 23332762; 8929531 129 22 172 -RAD17 RAD17 Cell cycle regulation O75943 5884 5q13.2 human S678-p 1184590201 IIIEDYEsDGT____ molecular association, regulation; phosphorylation RAD1(INDUCES) 29902452; 31353086 2 0 0 induces phosphorylation of other sites -RUNX3 AML2 DNA-binding; Transcription factor Q13761 864 1p36.11 human T173-p 55571501 YHRAIKVtVDGPREP Runt molecular association, regulation cell cycle regulation; transcription, induced DNA(DISRUPTS) 27217562 1 0 0 regulating mitotic entry -ESR1 ER-alpha DNA-binding; Nuclear receptor; Transcription factor P03372 2099 6q25.1-q25.2 human K303-ac 459012 LMIKRSKkNSLALSL activity, induced; activity, inhibited; phosphorylation cell growth, inhibited; transcription, inhibited; transcription, altered 11279135; 15604293; 18471979; 19887647 4 1 0 K302/303A mutants are more active then wt protein at low concentration of E2 ; inhibits phosphorylation at S305; makes K302 a poorer substrate for methylation; suppresses ligand sensitivity -AQP2 AQP2 Channel, misc.; Membrane protein, integral; Membrane protein, multi-pass; Transporter; Transporter, aquaporin family P41181 359 12q13.12 human S264-p 2238600 VELHSPQsLPRGTKA intracellular localization exocytosis, induced 22778181; 32529500 20 8 0 -PTH1R PTHR GPCR, family 2; Membrane protein, integral; Membrane protein, multi-pass; Receptor, GPCR Q03431 5745 3p21.31 human T387-p 801662704 NIVRVLAtKLRETNA 7tm_2 molecular association, regulation; ubiquitination ARRB1(INDUCES) 29444827 1 1 0 abrogation of phosphorylation at positions T387and T392 dramatically decreased PTHR ubiquitination -AKT1 Akt1 EC 2.7.11.1; KINASE; Kinase, protein; Oncoprotein; Protein kinase, AGC; Protein kinase, Ser/Thr (non-receptor) P31749 207 14q32.33 human T450-p 447857 TAQMITItPPDQDDS Pkinase_C protein stabilization; molecular association, regulation; enzymatic activity, inhibited; phosphorylation; enzymatic activity, induced; activity, induced; ubiquitination; protein conformation carcinogenesis, induced; cell motility, induced; apoptosis, induced; signaling pathway regulation; transcription, altered; cell differentiation, altered; translation, altered; cell growth, induced PIN1(INDUCES) 15065872; 16306447; 17446865; 19448664; 20186153; 21045808; 21577208; 33941854; 34385319; 35625759; 9690513 30 5 1 -SLC12A3 NCCT Membrane protein, integral; Membrane protein, multi-pass; Transporter; Transporter, SLC family P55017 6559 16q13 human S73-p 469631 TYEHYANsTQPGEPR AA_permease_N activity, induced; molecular association, regulation; protein conformation ADD3(DISRUPTS) 21164023; 36792826 15 2 1 -EEF2 EEF2 Translation; Translation elongation P13639 1938 19p13.3 human K322-sm 32005105 LIEKLDIkLDSEDKD GTP_EFTU phosphorylation 24648518 1 0 0 induces tyrosine phosphorylation of itself -EEF2 EEF2 Translation; Translation elongation P13639 1938 19p13.3 human S595-p 27620701 NVLCLSKsPNKHNRL ADP-ribosylation; activity, induced; protein conformation; phosphorylation cell cycle regulation 23184662; 30218597 2 2 0 EEF2-T56 phosphorylation; phosphorylation of this site interferes with toxin-mediated ADP-ribosylation of EEF2 at H175 -Ppp1r1a PPP1R1A Inhibitor; Protein phosphatase, regulatory subunit Q9ERT9 58200 15|15 F3 mouse T35-p 447759 QIRRRRPtPATLVLT DARPP-32 molecular association, regulation PPA1(DISRUPTS) 24244723 14 4 0 -Notch1 Notch 1 Membrane protein, integral; Motility/polarity/chemotaxis; Oncoprotein; Receptor, misc.; Transcription factor Q01705 18128 2 A3|2 18.91 cM mouse R2361-m2 409457000 YQGLPNTrLATQPHL activity, induced; protein degradation; ubiquitination transcription, induced 25805888 1 1 0 -Bmp2k BIKE EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, Other; Protein kinase, Ser/Thr (non-receptor) Q91Z96 140780 5|5 E3 mouse S1010-p 467549 KKVGRRDsQSSNEFL BMP2K_C intracellular localization 36739695 1 35 0 -POLH POLH DNA repair, damage; EC 2.7.7.7; Transferase Q9Y253 5429 6p21.1 human K619-sm 1877365914 SVLEVTQkATPNPSL intracellular localization; enzymatic activity, inhibited 32350109 1 1 0 -HPSE HPSE EC 3.2.1.166; Extracellular matrix; Glycan Metabolism - glycosaminoglycan degradation; Hydrolase; Secreted; Secreted, signal peptide Q9Y251 10855 4q21.23 human Y156-p 3785036 QLLLREHyQKKFKNS Glyco_hydro_79n enzymatic activity, induced 21831044 1 0 0 regulates neuritogenesis -Card11 CARD11 Adaptor/scaffold Q8CIS0 108723 5|5 G2 mouse S620-p 5403700 RYSFGPPsIHSSSSS activity, inhibited 19917688 3 0 0 -Raf1 RAF1 EC 2.7.11.1; KINASE; Kinase, protein; Oncoprotein; Protein kinase, Ser/Thr (non-receptor); Protein kinase, TKL Q99N57 110157 6 E3|6 53.62 cM mouse Y340-p 447749 RGQRDSSyYWEIEAS phosphorylation; enzymatic activity, induced apoptosis, altered 11296227; 17535812 29 1 1 Bad Ser 112 + 136 phosphorylation -Adrb2 ADRB2 GPCR, family 1; Membrane protein, integral; Membrane protein, multi-pass; Receptor, GPCR P18762 11555 18 E1|18 35.1 cM mouse S355-p 458916 KTYGNGYsSNSNGRT receptor internalization, induced; receptor internalization, altered cell motility, induced; signaling pathway regulation 18056263; 25460042; 27541735; 31088898 27 2 0 IRS2 is required for ADRB2 internalization; B-arrestin mediated signaling; internalization and the contraction response -MYB Myb DNA-binding; Oncoprotein; Transcription factor P10242 4602 6q23.3 human K471-ac 458941 PRTPTPFkHALAAQE Cmyb_C molecular association, regulation transcription, induced DNA(INDUCES) 10656693 1 4 1 -LMNB1 Lamin B1 Cytoskeletal P20700 4001 5q23.2 human S395-p 448732 LKLSPSPsSRVTVSR cell cycle regulation 8663071 3 11 1 -SOD2 SOD2 EC 1.15.1.1; Mitochondrial; Oxidoreductase P04179 6648 6q25.3 human K68-ac 461133 NLNVTEEkYQEALAK Sod_Fe_N protein stabilization; intracellular localization; enzymatic activity, inhibited; activity, inhibited; protein conformation; enzymatic activity, altered cell differentiation, inhibited; cell cycle regulation; carcinogenesis, induced; cell growth, induced; cell differentiation, induced; transcription, induced 21566644; 25908444; 27540894; 27721400; 28369333; 28584055; 28687409; 31160585; 31189433; 31591207; 33680286; 33867840 23 13 8 dysregulated mitochondrial structure and localization, acetylation mimetic disrupts mitochondrial ultrastructure and metabolism. -UBXN2B UBXN2B Adaptor/scaffold; Endoplasmic reticulum Q14CS0 137886 8q12.1 human S56-p 3217941 PKATVFKsPRTPPQR molecular association, regulation; intracellular localization 20875789 1 6 4 important for Golgi disassembly at mitosis; inhibits p37 binding to Golgi membranes -H3F3C H3 DNA-binding P84229 427887 chicken K4-m2 459004 ____ARTkQTARKST Histone chromatin organization, altered; transcription, induced 17913747 108 10 0 -Nfatc2 NFAT1 DNA-binding; Transcription factor Q60591 18019 2 H3|2 88.91 cM mouse S177-p 447843 SPASSGSsASFISDT transcription, inhibited 11030334 0 1 0 -Rap1gap RAP1GAP iso2 GAP; GAP, Ras; Motility/polarity/chemotaxis A2ALS5-2 110351 4 D3|4 70.02 cM mouse S563-p 3190708 PFGSRRSsAIGIENI neural plasticity; signaling pathway regulation 33301817 4 25 25 A2aR-PKA-Rap1-MAPK signaling pathway -Nrip1 RIP140 Nuclear receptor co-regulator; Transcription, coactivator/corepressor Q8CBD1 268903 16|16 C3.1 mouse Y364-p 25234802 SSPKNTSyKNSLERN protein degradation; ubiquitination 22388040 1 0 0 regulates inflamatory responses and contributes to endotoxin tolerance -Was WASP Adaptor/scaffold; Motility/polarity/chemotaxis P70315 22376 X A1.1|X 3.65 cM mouse Y293-p 447985 AETSKLIyDFIEDQG PBD activity, induced; protein stabilization cell motility, altered; cytoskeletal reorganization; cell growth, altered 14707117; 19805221; 24223520 12 35 657 -MAP3K8 Cot EC 2.7.11.25; KINASE; Kinase, protein; Oncoprotein; Protein kinase, STE; Protein kinase, Ser/Thr (non-receptor) P41279 1326 10p11.23 human T290-p 455276 FPKDLRGtEIYMSPE Pkinase protein degradation; molecular association, regulation; phosphorylation; enzymatic activity, induced NFkB-p105(DISRUPTS) 15466476; 15699325; 16806191 6 0 0 required for phosphorylation of Cot Ser62 -Cebpb C/EBP-beta DNA-binding; Motility/polarity/chemotaxis; Transcription factor P28033 12608 2 H3|2 87.58 cM mouse S184-p 455886 LSTSSSSsPPGTPSP activity, induced; molecular association, regulation; protein conformation cell cycle regulation; cell differentiation, altered; cell differentiation, induced; transcription, induced; transcription, altered C/EBP-beta(INDUCES) DNA(INDUCES) 15985551; 17264204; 17601773; 19478079 8 9 9 -RBPJ RBPJ Cell development/differentiation; Transcription factor Q06330 3516 4p15.2 human K175-ub 41493905 SKKKQSLkNADLCIA LAG1-DNAbind chromatin organization, altered; transcription, induced 36129980 1 2 0 positively regulates Notch signaling -NACA NACA iso1 Motility/polarity/chemotaxis; Transcription, coactivator/corepressor Q13765 4666 12q13.3 human S151-p 4712206 KVQGEAVsNIQENTQ intracellular localization; activity, inhibited cell differentiation, inhibited; transcription, inhibited 30948508 1 5 0 -IGFBP1 IGFBP1 Secreted; Secreted, signal peptide P08833 3484 7p12.3 human S126-p 451658 GSPESPEsTEITEEE activity, induced; molecular association, regulation; activity, inhibited; phosphorylation signaling pathway regulation IGF1(INDUCES); CK2B(INDUCES) 18772238; 20143870; 23354097; 25957086; 32502935; 7683525 14 10 0 regulates mTOR and AAR signaling; inhibits IGF-1RB autophosphorylation and activity; S126A and S144A mutants inhibit IGF1R autophosphorylation -GAB1 GAB1 Adaptor/scaffold; Motility/polarity/chemotaxis Q13480 2549 4q31.21 human Y589-p 449792 SHDSEENyVPMNPNL molecular association, regulation SHP-2(INDUCES); PIK3R1(INDUCES) 10978177; 9658397 8 0 0 -RAD52 RAD52 DNA repair, damage P43351 5893 12p13.33 human K192-ac 971232905 EVDLTKAkRQDLEPS molecular association, regulation; intracellular localization DNA repair, induced RFA2(INDUCES); RPA3(INDUCES); RAD51(INDUCES); RPA1(INDUCES) 29590107 1 1 0 accumulation of RAD52 at DSB sites -Sox11 SOX11 DNA-binding; Transcription factor Q7M6Y2 20666 12|12 A2 mouse S30-p 56654271 EGEFMACsPVALDES intracellular localization transcription, induced 29973868 1 2 0 promotes nuclear vs. cytoplasmic localization but export to the cytoplasm may support the transcriptional inactivation of SOX11 -SMAD6 SMAD6 DNA-binding; Transcription factor O43541 4091 15q22.31 human K173-ub 31914118 LLLEQELkTVTYSLL MH1 molecular association, regulation; phosphorylation cell differentiation, induced; transcription, induced; signaling pathway regulation ALK2(DISRUPTS) 23455153 1 0 0 enhances Smad1 phosphorylation -GPLD1 GPLD1 EC 3.1.4.50; Glycan Metabolism - glycosylphosphatidylinositol (GPI)-anchor biosynthesis; Phospholipase; Secreted; Secreted, signal peptide P80109 287025 cow T309-p 457382 NGFHKNVtAALTKNI enzymatic activity, inhibited 10384965 1 0 0 -Map2 MAP2 iso3 Cytoskeletal; Motility/polarity/chemotaxis P15146-3 25595 9q32 rat K314-ac 62495503 LPDLKNVkSKIGSTD Tubulin-binding cytoskeletal reorganization 28002468 1 1 0 -Ppp2ca PPP2CA EC 3.1.3.16; Motility/polarity/chemotaxis; PHOSPHATASE; Protein phosphatase, Ser/Thr (non-receptor) P63331 24672 10q22 rat Y307-p 448571 VTRRTPDyFL_____ activity, induced; molecular association, regulation; enzymatic activity, inhibited; phosphorylation autophagy, inhibited; translation, induced PPP2CB(DISRUPTS) 17537547; 20542922; 22892311; 23796501; 25391447; 26378614 73 1 0 may contribute to SNCA accumulation -AKAP8 AKAP8 Adaptor/scaffold; Cell cycle regulation; Mitochondrial; RNA-binding O43823 10270 19p13.12 human Y539-p 40420000 IVKMLEKyLKGEDPF AKAP95 molecular association, regulation 25770215 1 0 0 Phenylalanine mutants inhibited dissociation from nuclear structures; structural chromatin changes -CASR CaR GPCR, family 3; Membrane protein, integral; Membrane protein, multi-pass; Motility/polarity/chemotaxis; Receptor, GPCR P41180 846 3q13.33-q21.1 human T888-p 449862 FKVAARAtLRRSNVS activity, induced; receptor desensitization, altered; activity, inhibited; phosphorylation signaling pathway regulation 12356761; 12409307; 15212956; 17376781; 21135065; 24336654; 31189667; 36818436; 9694886 10 1 0 regulates Ca2+ sensitivity -ACHE AChE EC 3.1.1.7; Hydrolase; Lipid Metabolism - glycerophospholipid; Membrane protein, GPI anchor P22303 43 7q22.1 human Y164-p 10799701 GASSLDVyDGRFLVQ COesterase enzymatic activity, induced 7836436 1 0 0 -MAP4K4 HGK EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, STE; Protein kinase, Ser/Thr (non-receptor) O95819 9448 2q11.2 human T191-p 7320315 RRNTFIGtPYWMAPE Pkinase activity, induced; enzymatic activity, inhibited; phosphorylation carcinogenesis, inhibited; cell growth, inhibited; cell adhesion, induced; signaling pathway regulation 12612079; 31792377 2 2 5 pLATS1 at T1079; mostly blocked invasive response; Hippo pathway -PRKCE PKCE EC 2.7.11.13; KINASE; Kinase, protein; Protein kinase, AGC; Protein kinase, Ser/Thr (non-receptor) Q02156 5581 2p21 human S346-p 2807904 SEEDRSKsAPTSPCD molecular association, regulation cell cycle regulation; transcription, altered 14-3-3 beta(INDUCES); 14-3-3 zeta(INDUCES) 18458086; 18604201; 34143863 3 11 0 -NCOA3 SRC-3 ACETYLTRANSFERASE; Acetyltransferase; EC 2.3.1.48; Motility/polarity/chemotaxis; Nuclear receptor co-regulator; Transcription, coactivator/corepressor Q9Y6Q9 8202 20q13.12 human K620-ac 460610 LESKGHKkLLQLLTC SRC-1 molecular association, regulation transcription, inhibited ER-alpha(DISRUPTS) 10490106 1 0 2 -H3c1 H3 DNA-binding P68433 360198 13|13 A3.1 mouse K27-m3 1308913 LATKAARkSAPATGG Histone molecular association, regulation; intracellular localization cell differentiation, inhibited; endocytosis, altered; transcription, altered; cell differentiation, altered; RNA splicing, altered; chromatin organization, altered; cell differentiation, induced; cell adhesion, altered; transcription, inhibited DNMT3A(INDUCES) DNA(INDUCES) 16717091; 17967893; 18039862; 19303854; 19434510; 19567879; 19915707; 20147304; 20395309; 20543957; 20574709; 20935159; 22237151; 23362347; 23375371; 24070375; 24162653; 26716510; 33195484; 33986537; 35035682; 35640597 195 24 3 JMJD3 inhibited H3K27me3 methylation levels which promoted BDNF transcription ; H2AK119ub1 was with other modications and worked with H3K27me3 to inhibit transcription.; axon guidance -ZBTB16 PLZF C2H2-type zinc finger protein; DNA-binding; Oncoprotein; Transcription, coactivator/corepressor Q05516 7704 11q23.2 human T282-p 2134716 RGKEGPGtPTRSSVI protein degradation cell cycle regulation; transcription, altered; cell growth, altered 18246121 1 3 4 -EAF2 EAF2 Transcription regulation Q96CJ1 55840 3q13.33 human K81-ub 55591502 TVFKGSKkPYLKECI EAF apoptosis, inhibited 27058417 1 0 0 -HINT1 HINT1 Cytoskeletal; EC 3.-.-.-; Hydrolase P49773 3094 5q23.3 human K21-ac 461229 GGDTIFGkIIRKEIP molecular association, regulation carcinogenesis, induced; cell growth, induced; transcription, induced CTNNB1(DISRUPTS); MITF(INDUCES) 28394346; 32636443 2 7 14 -SMN1 SMN RNA processing; RNA-binding Q16637 6606 5q13.2 human Y130-p 1025402 CVVVYTGyGNREEQN SMN molecular association, regulation; intracellular localization coilin(INDUCES) 24602413 1 2 0 -NEDD9 Cas-L Adaptor/scaffold; Motility/polarity/chemotaxis Q14511 4739 6p24.2 human T804-p 348338201 AALHYPStTALQEMV CAS_C molecular association, regulation; intracellular localization cell motility, induced PLK1(NOT_REPORTED) 29191835 1 1 0 localization of HEF1 to FAs -SIT1 SIT Adaptor/scaffold; Membrane protein, integral Q9Y3P8 27240 9p13.3 human Y169-p 448964 SGPEPELyASVCAQT activity, inhibited 11433379 1 2 146 SIT inhibition of T cell activation -ZNF622 ZNF622 Transcription factor Q969S3 90441 5p15.1 human S314-p 20765001 WCNEKGKsFYSTEAV zf-C2H2_2 phosphorylation apoptosis, induced; transcription, induced; signaling pathway regulation 21771788 1 0 0 increases phosphorylation of ASK1 substrates. Suppress PDK1 signaling -PML PML Nucleolus; Oncoprotein; SUMO LIGASE; SUMO conjugating system; SUMO ligase; Transcription factor; Tumor suppressor; Ubiquitin conjugating system P29590 5371 15q24.1 human K616-sm 56709103 PLVFFDLkIDNETQK molecular association, regulation PIAS1(INDUCES) 27099310 1 1 0 regulators of host immunity to virus infection of HSV1 -MAP3K7 TAK1 EC 2.7.11.25; KINASE; Kinase, protein; Protein kinase, Ser/Thr (non-receptor); Protein kinase, TKL O43318 6885 6q15 human T178-ac 1880881708 LKICDFGtACDIQTH phosphorylation signaling pathway regulation 36270986 1 1 0 induces TAK1-ADAM17 signaling; inhibits phosphorylation of itself at T184/T187 -Ola1 OLA1 EC 3.6.3.-; Hydrolase; Nucleolus Q9CZ30 67059 2|2 C3 mouse Y236-p 1880539204 VNLSEKDyIRKKNKW protein stabilization; molecular association, regulation; ubiquitination; intracellular localization IMPA1(INDUCES) 36481055 1 1 0 inhibits ubiquitination -SOX6 SOX6 DNA-binding P35712 55553 11p15.2 human K417-sm 2407405 TSPVTQVkDEAAAQP intracellular localization transcription, inhibited 16442531 1 0 0 -Opn4 melanopsin GPCR, family 1; Membrane protein, integral; Membrane protein, multi-pass; Receptor, GPCR Q8R456 192223 16p15 rat S398-p 36745801 SSQSSDLsWISGQKR activity, induced 25378407 1 0 0 increases Ca2+ response -ABL2 Arg EC 2.7.10.2; KINASE; Kinase, protein; Oncoprotein; Protein kinase, TK; Protein kinase, tyrosine (non-receptor) P42684 27 1q25.2 human Y310-p 456544 YVGVWKKySLTVAVK PK_Tyr_Ser-Thr enzymatic activity, induced 34144039 1 4 56 -IKBKB IKKB EC 2.7.11.10; KINASE; Kinase, protein; Protein kinase, Other; Protein kinase, Ser/Thr (non-receptor) O14920 3551 8p11.21 human K238-ub 1881186500 WHSKVRQkSEVDIVV molecular association, regulation; phosphorylation NFkB-p105(DISRUPTS) 33523871 1 1 0 ubiquitylation inhibits phosphorylation of p105 -Mecp2 MECP2 Transcription, coactivator/corepressor Q9Z2D6 17257 X A7.3|X 37.63 cM mouse K223-sm 31089522 SPGKLVVkMPFQASP molecular association, regulation neural plasticity; transcription, inhibited HDAC1(INDUCES); HDAC2(INDUCES) 24188180 1 0 0 -SLC7A5 SLC7A5 Membrane protein, integral; Membrane protein, multi-pass; Transporter; Transporter, SLC family Q01650 8140 16q24.2 human K25-ub 21185156 EKEEAREkMLAAKSA protein degradation endocytosis, induced 31728037 1 5 0 PMA-induced endocytosis -PRKCA PKCA EC 2.7.11.13; KINASE; Kinase, protein; Oncoprotein; Protein kinase, AGC; Protein kinase, Ser/Thr (non-receptor) P17252 5578 17q24.2 human Y658-p 455927 SDFEGFSyVNPQFVH Pkinase_C intracellular localization 16627824 5 0 0 -Nefm NFM Cytoskeletal P08553 18040 14|14 D1 mouse S506-p 448042 AEKSPVKsPEAKEEE cytoskeletal reorganization 19193875 3 5 6 slightly altered axoplasmic organization in 7S/A mice mutant -Clock CLOCK ACETYLTRANSFERASE; Acetyltransferase; DNA-binding; EC 2.3.1.48; Transcription factor O08785 12753 5 C3.3|5 40.63 cM mouse S42-p 7911902 KRVSRNKsEKKRRDQ HLH protein degradation; intracellular localization transcription, inhibited DNA(DISRUPTS) 19414601 1 1 0 inhibits transcription -Lpcat1 LPCAT1 ACETYLTRANSFERASE; Acetyltransferase; EC 2.3.1.23; EC 2.3.1.67; Endoplasmic reticulum; Membrane protein, integral Q3TFD2 210992 13|13 C1 mouse S182-p 17533101 VSRSDQDsRRKTVEE Acyltransferase protein degradation; ubiquitination 21068446 1 0 0 -Lima1 eplin Actin-binding; Cytoskeletal; Motility/polarity/chemotaxis Q9ERG0 65970 15 F1|15 56.13 cM mouse S692-p 460654 NHVHAQQsPLEPEAP molecular association, regulation cell motility, induced; cytoskeletal reorganization ACTB(DISRUPTS) 17875928 1 27 26 destabilization of stress fibres, membrane ruffle formation -L3MBTL2 L3MBTL2 Histone-binding Q969R5 83746 22q13.2 human K675-sm 31089506 EIIAVRVkEEHLDVA ubiquitination transcription, inhibited 24369422 2 2 0 induces Histone ubiquitination -RELA NFkB-p65 DNA-binding; Nuclear receptor co-regulator; Transcription factor Q04206 5970 11q13.1 human R174-m2 54221300 DPSGRPLrLPPVLSH RHD_DNA_bind transcription, induced DNA(INDUCES) 26901772 1 1 0 expression of CXCL11 -Irf1 IRF1 Transcription factor; Tumor suppressor P15314 16362 11 B1.3|11 32.0 cM mouse T181-p 1380568700 LDMERDItPALSPCV protein degradation; molecular association, regulation; ubiquitination cell growth, inhibited; transcription, induced FBXW7(INDUCES) 30854564 1 0 0 de-stabilization of chromatin-associated IRF1; induced expression of TRAIL, OAS3, PSMA6, and TBC1D32; RNA-Pol-II elongation; anti-proliferative activity in cancer cells -CCAR2 DBC-1 Apoptosis; Mitochondrial; Nuclear receptor co-regulator; RNA-binding; Tumor suppressor Q8N163 57805 8p21.3 human K112-ac 31068002 AVPWNAVkVQTLSNQ S1-like molecular association, regulation apoptosis, induced; transcription, inhibited SIRT1(DISRUPTS) 23892437; 24126058 2 2 0 -NUMA1 NuMA-1 Cell cycle regulation; Motility/polarity/chemotaxis Q14980 4926 11q13.4 human T1804-p 3196649 FLDSGRKtRSARRRT intracellular localization cell growth, induced; apoptosis, inhibited 23097092 1 3 1 cell proliferation increased -Cd22 CD22 Cell surface; Membrane protein, integral P35329 12483 7 B1|7 19.26 cM mouse Y817-p 459310 NNSDSVTySVIQKRP molecular association, regulation; phosphorylation SHP-1(INDUCES) 18024433 3 2 5 -Ret Ret EC 2.7.10.1; KINASE; Kinase, protein; Membrane protein, integral; Oncoprotein; Protein kinase, TK; Protein kinase, tyrosine (receptor) P35546 19713 6 F1|6 55.86 cM mouse Y1063-p 447625 TWIENKLyGMSDPNW molecular association, regulation; enzymatic activity, induced cell growth, induced; transcription, induced; cytoskeletal reorganization DOK4(INDUCES); DOK2(INDUCES); DOK1(INDUCES); DOK5(INDUCES) 11470823; 12087092; 25970250; 33561442 42 2 2 -SDC2 syndecan-2 Cell adhesion; Cell surface; Membrane protein, integral; Motility/polarity/chemotaxis P34741 6383 8q22.1 human Y179-p 448375 RKKDEGSyDLGERKP Syndecan molecular association, regulation RACK1(INDUCES) 16997272 2 2 6 -Cd5 CD5 Cell surface; Membrane protein, integral P13379 12507 19 A|19 7.16 cM mouse Y464-p 450105 RNSHLSAyPALEGAL molecular association, regulation PIK3R1(NOT_REPORTED) 9079809 4 1 22 -EHHADH EHHADH Amino Acid Metabolism - lysine degradation; Amino Acid Metabolism - tryptophan; Amino Acid Metabolism - valine, leucine and isoleucine degradation; Carbohydrate Metabolism - butanoate; Carbohydrate Metabolism - propanoate; EC 1.1.1.35; EC 4.2.1.17; EC 5.3.3.8; Isomerase; Lipid Metabolism - fatty acid; Lyase; Mitochondrial; Other Amino Acids Metabolism - beta-alanine; Oxidoreductase; Secondary Metabolites Metabolism - limonene and pinene degradation Q08426 1962 3q27.2 human K584-ac 461837 KGWYQYDkPLGRIHK enzymatic activity, induced 20167786 0 7 24 -SIK2 QIK EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, CAMK; Protein kinase, Ser/Thr (non-receptor) Q9H0K1 23235 11q23.1 human S587-p 3212040 FREGRRAsDTSLTQG enzymatic activity, inhibited 24841198 4 35 17 -Map3k5 ASK1 EC 2.7.11.25; KINASE; Kinase, protein; Protein kinase, STE; Protein kinase, Ser/Thr (non-receptor) O35099 26408 10|10 A3 mouse S973-p 447736 NEYLRSIsLPVPVLV enzymatic activity, inhibited; phosphorylation apoptosis, induced; transcription, altered 19920149; 36418313 17 4 1 inhibits JNK phosphorylation -MYBL2 B-Myb DNA-binding; Motility/polarity/chemotaxis; Transcription factor P10244 4605 20q13.12 human S577-p 450115 RKPGLRRsPIKKVRK Cmyb_C molecular association, regulation; protein conformation; phosphorylation cell cycle regulation; transcription, induced PIN1(INDUCES); B-Myb(DISRUPTS) DNA(DISRUPTS) 32979888 5 0 0 primes for phosphorylation at T487 -STIM1 STIM1 Calcium-binding; Endoplasmic reticulum; Membrane protein, integral Q13586 6786 11p15.4 human Y316-p 1870020002 NERSRQKyAEEELEQ molecular association, regulation; activity, inhibited ORAI1(INDUCES); TMEM66(DISRUPTS) 30975919 1 0 0 -IRF9 IRF9 DNA-binding; Transcription factor Q00978 10379 14q12 human S252-p 1881230100 AEPSGSEsSMEQVLF transcription, altered 36662450 1 1 0 -ITM2A ITM2A Membrane protein, integral O43736 9452 Xq21.1 human T35-p 1869192400 TVRTQILtGKELRVA enzymatic activity, induced carcinogenesis, inhibited; autophagy, induced 31438969 1 1 0 mTOR enzymatic activity induced -FLNB FLNB Actin-binding; Motility/polarity/chemotaxis O75369 2317 3p14.3 human K1147-ub 27583503 GPGLEHGkVGEAGLL Filamin molecular association, regulation; intracellular localization HDAC7(INDUCES) 23401860 1 0 0 PMA treatment enhances ubiquitination of FLNB and led to an increase in HDAC7 cytoplasmic accumulation. -BRCA1 BRCA1 EC 6.3.2.-; Nuclear receptor co-regulator; Transcription, coactivator/corepressor; Tumor suppressor; UBIQUITIN LIGASE; Ubiquitin conjugating system; Ubiquitin ligase P38398 672 17q21.31 human T1394-p 1874020208 SQSDILTtQQRDTMQ cell cycle regulation; carcinogenesis, altered; DNA repair, altered 34301763 1 1 0 -HSP90AA1 HSP90A Chaperone; Heat shock protein P07900 3320 14q32.31 human K292-ac 2884403 IDQEELNkTKPIWTR HSP90 molecular association, regulation TEBP(DISRUPTS); HSP70(DISRUPTS); HSP40(DISRUPTS) 18559531 1 6 2 -Ccne1 CCNE1 Activator; Cell cycle regulation; Nuclear receptor co-regulator Q61457 12447 7 B3|7 25.35 cM mouse T74-p 454411 DPCSFIPtPNKEEDN protein degradation; ubiquitination; methylation; activity, inhibited; phosphorylation cell cycle regulation; cell differentiation, altered; cell differentiation, induced; apoptosis, inhibited; DNA repair, altered; transcription, altered; cell growth, altered 18559482; 23873023; 24958101 8 1 0 using knock-in mutations impaired Fbw7-mediated degradation; T74A/T393A mutation causes increased Cdk2 kinase activity and stability and regulation by Fbw7. ; required for HSCs' multilineage reconstitution ability, and prevention of chromosome instability (CIN); regulation of oxidative metabolism and ROS production during terminal maturation; Phosphorylation at T74 and T393 causes dephosphorylation of Rb and demethylation of H3K9 -PTEN PTEN Carbohydrate Metabolism - inositol phosphate; EC 3.1.3.16; EC 3.1.3.48; EC 3.1.3.67; Motility/polarity/chemotaxis; Nuclear receptor co-regulator; PHOSPHATASE; Phosphatase, lipid; Tumor suppressor P60484 5728 10q23.31 human S370-p 448649 TSVTPDVsDNEPDHY molecular association, regulation; protein stabilization; intracellular localization; enzymatic activity, inhibited PTEN(DISRUPTS); RAD52(INDUCES) 11035045; 17565999; 24047694 12 7 0 facilitates translocation to chromatin and interaction with RAD52 -AMD1 AMD1 Amino Acid Metabolism - arginine and proline; Amino Acid Metabolism - cysteine and methionine; EC 4.1.1.50; Lyase P17707 262 6q21 human S298-p 3181139 KCRTVLAsPQKIEGF SAM_decarbox protein stabilization 28658205 1 6 0 -FDX1 adrenodoxin Mitochondrial P00257 281157 cow T129-p 455475 FEKLEAItDEENDML Fer2 molecular association, regulation CYP11A1(INDUCES) 15751958; 17358057 2 4 0 -Map2k1 MEK1 EC 2.7.12.2; KINASE; Kinase, protein; Protein kinase, STE; Protein kinase, dual-specificity (non-receptor) P31938 26395 9 C|9 34.55 cM mouse S222-p 448513 LIDSMANsFVGTRSY Pkinase enzymatic activity, induced cell growth, altered 10749122; 16103085; 7731726 117 20 203 -CGAS cGAS EC 2.7.7.86 Q8N884 115004 6q13 human K414-ub 12389582 KDCLKLMkYLLEQLK Mab-21_C protein degradation; molecular association, regulation autophagy, induced; signaling pathway regulation SQSTM1(INDUCES) 27666593 2 3 4 promotes type I-interferon signaling -Nlrp3 NLRP3 Inhibitor Q8R4B8 216799 11|11 B1.3 mouse K380-ub 1881493601 KRKEYFFkYFSNELQ NACHT protein degradation 33976226 1 0 0 -TGFB1 TGFB1 Motility/polarity/chemotaxis; Secreted; Secreted, signal peptide P01137 7040 19q13.2 human K315-ub 1881978301 WKWIHEPkGYHANFC TGF_beta protein degradation 35701426 1 1 0 p62-dependent autophagic degradation of TGFB1 -CDC25B CDC25B EC 3.1.3.48; Motility/polarity/chemotaxis; Nuclear receptor co-regulator; PHOSPHATASE; Protein phosphatase, dual-specificity P30305 994 20p13 human S375-p 455380 ARVLRSKsLCHDEIE M-inducer_phosp molecular association, regulation 14-3-3 beta(INDUCES) 11333986 4 24 2 -TGS1 PIMT EC 2.1.1.-; METHYLTRANSFERASE; Methyltransferase; Nuclear receptor co-regulator; RNA processing Q96RS0 96764 8q12.1 human S656-p 1881245402 AQRYRLFsRFDDGIK molecular association, regulation; phosphorylation transcription, altered; signaling pathway regulation p300(INDUCES) 36866247 1 0 0 induces PKA-PIMT-Ep300 signaling, regulates AKT phosphorylation -SHC4 SHC4 Adaptor/scaffold Q6S5L8 399694 15q21.1 human Y374-p 3654466 EEREDHEyYNEIPGK molecular association, regulation SHP-2(INDUCES) 28213521 1 2 4 -LMNA lamin A/C Cytoskeletal P02545 4000 1q22 human S390-p 452605 EEERLRLsPSPTSQR activity, induced; intracellular localization; phosphorylation chromatin organization, altered; DNA repair, inhibited 18815303; 37378334 5 119 129 induces H2AX phosphorylation; nuclear lamin disassemby -GRHL3 GRHL3 DNA-binding; Transcription factor Q8TE85 57822 1p36.11 human T454-p 1077816900 RPETDLEtPPVLFIP transcription, inhibited 29702134 1 1 0 -Ncam1 NCAM1 Cell adhesion; Membrane protein, GPI anchor; Membrane protein, integral; Motility/polarity/chemotaxis P13596 24586 8q23 rat S784-p 456432 AAFSKDEsKEPIVEV molecular association, regulation CRMP-2(INDUCES) 23377853 2 32 2 -MCM2 MCM2 DNA-binding; EC 3.6.4.12 P49736 4171 3q21.3 human S40-p 452311 RRTDALTsSPGRDLP molecular association, regulation; enzymatic activity, induced cell cycle regulation; carcinogenesis, induced; chromatin organization, altered; apoptosis, inhibited; cell growth, altered DNA(INDUCES) 16446360; 17062569; 25843623; 28273463; 31578521 12 29 18 loss of CDC7 induce senescence in liver cancer cells -PTK2 FAK EC 2.7.10.2; KINASE; Kinase, protein; Protein kinase, TK; Protein kinase, tyrosine (non-receptor) Q05397 5747 8q24.3 human S732-p 450196 SSEGFYPsPQHMVQT cell motility, altered; cell adhesion, altered 16760434 5 1 0 triggers the formation of the ventral focal adhesions -Wwtr1 TAZ Oncoprotein; Transcription, coactivator/corepressor Q9EPK5 97064 3|3 D mouse S89-p 457660 AQHVRSHsSPASLQL molecular association, regulation; intracellular localization transcription, inhibited 14-3-3 epsilon(INDUCES); 14-3-3 epsilon(DISRUPTS) 11118213; 25362852; 25961935; 35619099 31 20 79 -HIPK2 HIPK2 EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, CMGC; Protein kinase, Ser/Thr (non-receptor) Q9H2X6 28996 7q34 human Y367-p 1033356 TYLQSRYyRAPEIIL Pkinase protein stabilization; intracellular localization apoptosis, induced; transcription, induced 25944899 1 1 0 -PDGFRB PDGFRB EC 2.7.10.1; KINASE; Kinase, protein; Membrane protein, integral; Oncoprotein; Protein kinase, TK; Protein kinase, tyrosine (receptor) P09619 5159 5q32 human Y771-p 447517 ADIESSNyMAPYDNY PK_Tyr_Ser-Thr molecular association, regulation RASA1(INDUCES); Arg(INDUCES); SHC1(INDUCES) 11896619; 1314164; 1375321; 34144039; 7935391; 8195171 14 4 5 Y579 most important for Shc binding. Phosphorylation of Shc not dependent on individual PDGFRB sites. -BCR Bcr EC 2.7.11.1; GAP; GAP, Rac/Rho; GEF, Rac/Rho; KINASE; Kinase, protein; Oncoprotein; Protein kinase, Ser/Thr (non-receptor); Protein kinase, atypical P11274 613 22q11.23 human S354-p 447791 SGQSSRVsPSPTTYR molecular association, regulation apoptosis, induced Abl iso2(INDUCES) 11809685 3 13 60 -Bach2 BACH2 DNA-binding; Transcription factor P97303 12014 4|4 A5 mouse K201-sm 2798314 TAIPVAEkEEALLPE intracellular localization transcription, inhibited 15060166 2 0 0 formation of PML bodies -RB1 Rb Nuclear receptor co-regulator; Oncoprotein; Transcription, coactivator/corepressor; Tumor suppressor P06400 5925 13q14.2 human S788-p 450022 PIPHIPRsPYKFPSS Rb_C molecular association, regulation cell growth, altered E2F1(DISRUPTS); TFDP1(DISRUPTS) 16360038; 9315635 12 20 79 -IKBKB IKKB EC 2.7.11.10; KINASE; Kinase, protein; Protein kinase, Other; Protein kinase, Ser/Thr (non-receptor) O14920 3551 8p11.21 human Y188-p 449632 SFVGTLQyLAPELLE Pkinase activity, induced transcription, altered 12645577; 12707358 6 0 0 -Vim Vimentin Cytoskeletal; Motility/polarity/chemotaxis P20152 22352 2 A1|2 10.04 cM mouse S8-p 471087 MSTRSVSsSSYRRMF Filament_head molecular association, regulation endocytosis, induced JAG1(INDUCES) 28533359 3 3 1 transendocytosis -XRCC1 XRCC1 DNA repair, damage P18887 7515 19q13.31 human T284-p 5014905 APTRTPAtAPVPARA activity, induced; molecular association, regulation cell growth, altered MPG(INDUCES); CCNO(INDUCES) 18971944 1 1 0 promotes base excision repair -USP25 USP25 DEUBIQUITINASE; EC 3.4.19.12; Protease; Ubiquitin conjugating system; Ubiquitin-specific protease Q9UHP3 29761 21q21.1 human K141-sm 3084636 EASIAENkACLKRTP ubiquitination; enzymatic activity, inhibited 18538659 1 0 0 sumoylation inhibits ubiquitin chain hydrolysis and has reduced afinity to ubiquitin chains -SMAD4 SMAD4 DNA-binding; Nuclear receptor co-regulator; Transcription, coactivator/corepressor Q13485 4089 18q21.2 human K519-ub 7388009 DYPRQSIkETPCWIE MH2 protein degradation cell differentiation, induced; signaling pathway regulation 19135894; 28468752 2 3 0 TGF-beta signaling; inhibits Activin-BMP signaling -GALNT2 GALNT2 EC 2.4.1.41; Glycan Metabolism - O-glycan biosynthesis; Membrane protein, integral; Transferase Q10471 2590 1q42.13 human K103-ac 25336505 QDPYARNkFNQVESD enzymatic activity, inhibited; O-GalNAc glycosylation 21651894 0 1 0 inhibits glycosylation of mucin -PA2G4 Ebp1 Nuclear receptor co-regulator; Nucleolus; Transcription, coactivator/corepressor Q9UQ80 5036 12q13.2 human T261-p 2303906 QYGLKMKtSRAFFSE Peptidase_M24 activity, inhibited cell growth, induced; transcription, induced 18283314 2 0 0 -Map3k1 MEKK1 EC 2.7.11.25; KINASE; Kinase, protein; Ligase; Protein kinase, STE; Protein kinase, Ser/Thr (non-receptor); UBIQUITIN LIGASE; Ubiquitin conjugating system; Ubiquitin ligase P53349 26401 13 D2.2|13 63.36 cM mouse T1381-p 448078 ARLASKGtGAGEFQG Pkinase enzymatic activity, induced 25260751; 9078260 3 0 0 -Raf1 RAF1 EC 2.7.11.1; KINASE; Kinase, protein; Oncoprotein; Protein kinase, Ser/Thr (non-receptor); Protein kinase, TKL Q99N57 110157 6 E3|6 53.62 cM mouse S621-p 447746 PKINRSAsEPSLHRA protein stabilization; molecular association, regulation 14-3-3 beta(INDUCES); ROCK2(DISRUPTS); BRAF iso1(INDUCES) 11782426; 18922468; 28270557 24 70 10 -AR AR DNA-binding; Nuclear receptor; Transcription factor P10275 367 Xq12 human S215-p 448577 SGRAREAsGAPTSSK Androgen_recep activity, induced; protein degradation; molecular association, regulation; protein stabilization; ubiquitination; intracellular localization; activity, inhibited cell cycle regulation; carcinogenesis, induced; cell growth, induced; apoptosis, inhibited; transcription, induced; signaling pathway regulation; transcription, altered MDM2(INDUCES) 11404460; 17470458; 21601007; 22155408; 22584579; 29423094; 31429764 15 0 0 -NUMA1 NuMA-1 Cell cycle regulation; Motility/polarity/chemotaxis Q14980 4926 11q13.4 human S2087-p 28722901 TRSGTRRsPRIATTT cell growth, induced; apoptosis, inhibited 23097092 2 2 0 cell proliferation increased -Rasgrf1 RASGRF1 GEF; GEF, Ras P28818 192213 8q31 rat S898-p 448487 KEIYRRMsLANTGYS activity, induced; intracellular localization cytoskeletal reorganization; cell growth, altered 12538592 3 0 0 -PDE5A PDE5A EC 3.1.4.35; Nucleotide Metabolism - purine; Phosphodiesterase O76074 8654 4q26 human S104-p 36392501 PTRKISAsEFDRPLR enzymatic activity, inhibited; protein conformation 25247292 1 0 0 -GORASP2 GRASP55 Motility/polarity/chemotaxis; Vesicle Q9H8Y8 26003 2q31.1 human S189-p 31949801 SAWGGEGsLGCGIGY GRASP55_65 protein conformation 24505136 1 0 0 inhibits tethering -DSTN Destrin Actin-binding; Motility/polarity/chemotaxis P60981 11034 20p12.1 human S3-p 449754 _____MAsGVQVADE cytoskeletal reorganization; cell adhesion, altered 11171090 4 47 1 -ARAF ARAF EC 2.7.11.1; KINASE; Kinase, protein; Oncoprotein; Protein kinase, Ser/Thr (non-receptor); Protein kinase, TKL P10398 369 Xp11.3 human T442-p 3306325 IFLHEGLtVKIGDFG PK_Tyr_Ser-Thr enzymatic activity, induced 18662992 0 1 0 -WWOX WWOX Apoptosis; EC 1.1.1.-; Oxidoreductase; Tumor suppressor Q9NZC7 51741 16q23.1-q23.2 human Y33-p 449043 TTKDGWVyYANHTEE WW molecular association, regulation; intracellular localization; protein conformation; enzymatic activity, induced apoptosis, altered; carcinogenesis, inhibited; cell growth, inhibited; apoptosis, induced; transcription, induced; cell motility, inhibited; signaling pathway regulation; cell growth, induced HYAL2(INDUCES); TIAF1(INDUCES); p53(INDUCES); JNK1(DISRUPTS); p73(INDUCES); JNK1(INDUCES); p73(DISRUPTS) 12514174; 15070730; 15664696; 16115915; 16219768; 18371080; 19366691; 24899407; 26120275; 27845895; 31315632; 31752354; 32185845 21 1 0 in 4T1 cells; Erk/WWOX signaling -MS4A2 FcER1B Membrane protein, integral; Membrane protein, multi-pass; Receptor, misc. Q01362 2206 11q12.1 human Y219-p 454405 KVPEDRVyEELNIYS molecular association, regulation LYN(INDUCES) 15339926 2 1 0 -COL17A1 COL17A1 Extracellular matrix; Membrane protein, integral; Motility/polarity/chemotaxis Q9UMD9 1308 10q25.1 human S542-p 484006 LDKIGLHsDSQEELW cell adhesion, altered 17545155 1 0 0 regulates COL17A1 shedding of ectodomain -Cct2 CCT2 Chaperone P80314 12461 10|10 D2 mouse S260-p 472352 GSRVRVDsTAKVAEI Cpn60_TCP1 molecular association, regulation 21440620 3 19 249 chaperonin protein folding -MAP2K4 MKK4 EC 2.7.12.2; KINASE; Kinase, protein; Protein kinase, STE; Protein kinase, dual-specificity (non-receptor) P45985 6416 17p12 human K140-ub 11998604 IRSTVDEkEQKQLLM Pkinase protein degradation 19737936 1 0 0 -CALR Calreticulin ACETYLTRANSFERASE; Acetyltransferase; Calcium-binding; Motility/polarity/chemotaxis; Nuclear receptor co-regulator; Secreted; Secreted, signal peptide P27797 811 19p13.13 human K62-ac 4219815 KFYGDEEkDKGLQTS Calreticulin protein conformation 18795239 1 3 0 -Stk39 STLK3 EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, STE; Protein kinase, Ser/Thr (non-receptor) Q9Z1W9 53416 2|2 C1.3 mouse S383-p 456506 VRRVPGSsGHLHKTE intracellular localization; phosphorylation; enzymatic activity, induced 20463172; 23940364; 24808538; 25651563; 26108786 20 20 1 apical phosphorylation at the apical membrane of DCT segments that is absent in SPAK KO mice; Increased phosphorylation of T96 and T101 of NKCC2; Regulatory volume increase (RVI) induced. Activity of NKCC1 cotransporter induced -PPP1R2 PPP1R2 Inhibitor; Motility/polarity/chemotaxis; Protein phosphatase, regulatory subunit P41236 5504 3q29 human S72-p 3190237 LMKIDEPsTPYHSMM IPP-2 cell motility, altered 26590424 2 1 0 -CACNA1C CACNA1C Channel, calcium; Membrane protein, integral; Membrane protein, multi-pass BAA34185.2 guinea pig S1699-p 4714250 PEIRRAIsGDLTAEE CAC1F_C activity, induced; molecular association, regulation; protein conformation Calmodulin(DISRUPTS) 30042022 17 7 0 -MEF2C MEF2C DNA-binding; Transcription factor Q06413 4208 5q14.3 human K239-ac 12674407 LNKNMQAkSPPPMNL molecular association, regulation cell differentiation, induced; transcription, induced MRF(INDUCES) DNA(INDUCES) 15831463 1 0 0 -MUS81 MUS81 Deoxyribonuclease; EC 3.1.22.-; Nucleolus Q96NY9 80198 11q13.1 human K10-sm 1872852104 APVRLGRkRPLPACP cell cycle regulation; DNA repair, induced 28318385 1 0 0 regulates genomic stability and chromosome alignment -MAP3K5 ASK1 EC 2.7.11.25; KINASE; Kinase, protein; Protein kinase, STE; Protein kinase, Ser/Thr (non-receptor) Q99683 4217 6q23.3 human T825-p 34366326 LKISDFGtSKRLAGI Pkinase protein conformation; enzymatic activity, induced apoptosis, induced; transcription, induced 28888991 1 0 1 dimerization -VIM Vimentin Cytoskeletal; Motility/polarity/chemotaxis P08670 7431 10p13 human K120-ac 475919 RFANYIDkVRFLEQQ Filament carcinogenesis, induced; cell motility, induced 30659753; 30662803 2 8 3 EMT in HCC -Stk11 LKB1 Autophagy; EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, CAMK; Protein kinase, Ser/Thr (non-receptor); Tumor suppressor Q9WTK7 20869 10|10 C1 mouse S431-p 448147 SNKIRRLsACKQQ__ intracellular localization; phosphorylation; enzymatic activity, induced carcinogenesis, inhibited; autophagy, induced; cell differentiation, induced; apoptosis, inhibited; cytoskeletal reorganization; cell growth, altered BRSK1(INDUCES); AMPKA1(INDUCES); Tau(INDUCES) 11297520; 17482548; 17482549; 31930700; 34006524 33 2 3 -PHKB PHKB KINASE; Protein kinase, regulatory subunit P12798 100009137 rabbit S27-p 470138 ARTKRSGsVYEPLKS molecular association, regulation 17123541 2 26 6 Mutations of S12 and S27 increased Beta subunit self interactions. -KCNQ3 Kv7.3 Channel, potassium; Membrane protein, integral; Membrane protein, multi-pass O43525 3786 8q24.22 human T246-p 457688 RMDRRGGtWKLLGSA Ion_trans; TM activity, induced 16319223 1 1 0 -NFATC2 NFAT1 DNA-binding; Transcription factor Q13469 4773 20q13.2 human S79-p 628303302 YSPLASLsGEPPGRF molecular association, regulation; intracellular localization transcription, induced PPP3CA(INDUCES) 29357353 1 0 0 nuclear translocation, TCR-mediated IL-2 and TNF-alpha production -Sgo1 SGO1 Cell cycle regulation Q9CXH7 72415 17|17 C mouse S73-p 2535906 LALENEKsKVREAQD intracellular localization 18331714 1 0 0 S73A and T146A mutants do not localize to the spindle pole region -Mitf MITF iso8 DNA-binding; Oncoprotein; Transcription factor Q08874-8 17342 6 D3|6 45.05 cM mouse K316-sm 3590700 DLVNRIIkQEPVLEN DUF3371 molecular association, regulation transcription, inhibited hnRNP P2(DISRUPTS); SMARCA4(DISRUPTS) 24257758 3 1 0 -Tph1 TPH1 Amino Acid Metabolism - tryptophan; EC 1.14.16.4; Oxidoreductase P09810 rat S58-p 451575 RKSKRRNsEFEIFVD enzymatic activity, induced 9109552 4 1 0 -Tgif1 TGIF DNA-binding; Nuclear receptor co-regulator; Transcription, coactivator/corepressor P70284 21815 17|17 E1.3 mouse K259-ub 12159004 LLVDVALkRAAEMEL protein stabilization 20064471 1 0 0 -Dapk1 DAPK1 Apoptosis; Autophagy; EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, CAMK; Protein kinase, Ser/Thr (non-receptor) Q80YE7 69635 13 B2|13 32.53 cM mouse S308-p 448142 ARKKWKQsVRLISLC protein degradation; molecular association, regulation; enzymatic activity, inhibited apoptosis, altered; apoptosis, induced CHIP(DISRUPTS); NMDAR2B(DISRUPTS); MIB1(DISRUPTS); Calmodulin(DISRUPTS) 15729359; 17056602; 17324930; 18806755; 20141836; 28614711 11 4 0 -RAF1 RAF1 EC 2.7.11.1; KINASE; Kinase, protein; Oncoprotein; Protein kinase, Ser/Thr (non-receptor); Protein kinase, TKL P04049 5894 3p25.2 human S624-p 18014563 NRSASEPsLHRAAHT molecular association, regulation; phosphorylation BRAF(DISRUPTS); 14-3-3 beta(DISRUPTS) 37625591 1 4 0 inhibits phosphorylation of itself at S338 and also MEK phosphorylation -RICTOR RICTOR Adaptor/scaffold; Cell cycle regulation; Ubiquitin conjugating system Q6R327 253260 5p13.1 human K1116-ac 41692100 HRSSSDPkGGKLSSE RICTOR_phospho signaling pathway regulation 26170313 1 0 0 induces mTORC2 signaling -NEK2 NEK2 EC 2.7.11.1; KINASE; Kinase, protein; Nucleolus; Protein kinase, Other; Protein kinase, Ser/Thr (non-receptor) P51955 4751 1q32.3 human T170-p 4271902 ARILNHDtSFAKTFV Pkinase enzymatic activity, induced 17197699 1 1 0 -DCX Doublecortin iso2 Cytoskeletal; Motility/polarity/chemotaxis O43602-2 1641 Xq23 human S334-p 451359 SPISTPTsPGSLRKH intracellular localization cell motility, altered; cytoskeletal reorganization 14765123 4 5 17 affects doublecortin localization to growth cones, neurite outgrowth, and neuronal motility -GIT2 GIT2 GAP; GAP, ARF; Motility/polarity/chemotaxis Q9Y621 374035 chicken Y392-p 456754 QDNDQPDyDSVASDE molecular association, regulation; intracellular localization cell adhesion, altered PXN(INDUCES) 16000375 1 6 25 -RHOU RHOU G protein; G protein, monomeric; G protein, monomeric, Rho; Motility/polarity/chemotaxis Q7L0Q8 58480 1q42.13 human Y254-p 14918203 SKSWWKKyCCFV___ molecular association, regulation; intracellular localization; activity, inhibited cytoskeletal reorganization; cell growth, altered PAK1(DISRUPTS) 20547754 1 0 0 -HDAC1 HDAC1 DEACETYLASE; Deacetylase; EC 3.5.1.98; Hydrolase; Nuclear receptor co-regulator Q13547 3065 1p35.2-p35.1 human S423-p 447913 CEEEFSDsEEEGEGG molecular association, regulation; enzymatic activity, induced SIN3A(INDUCES) 11602581 1 69 39 -GYS1 GYS1 Carbohydrate Metabolism - starch and sucrose; EC 2.4.1.11; Transferase P13807 2997 19q13.33 human S8-p 449898 MPLNRTLsMSSLPGL enzymatic activity, inhibited 19339242; 35793618 16 1 0 -STAT3 STAT3 DNA-binding; Motility/polarity/chemotaxis; Nuclear receptor co-regulator; Transcription factor P40763 6774 17q21.2 human K685-ac 458927 PKEEAFGkYCRPESQ activity, induced; protein stabilization; molecular association, regulation; methylation; intracellular localization; phosphorylation cell differentiation, inhibited; cell cycle regulation; carcinogenesis, induced; cell motility, induced; transcription, induced; signaling pathway regulation; cell differentiation, induced; cell growth, induced; apoptosis, inhibited; transcription, inhibited DMAP1(INDUCES); STAT3(INDUCES); CD44(INDUCES); DNMT1(INDUCES); ER-alpha(INDUCES) DNA(INDUCES) 15649887; 17917251; 19506034; 21098725; 21701559; 22116549; 26675255; 27086926; 27582487; 28445726; 29137356; 31170499; 31409371; 32393833; 33446662; 33859766 27 2 0 Acetylated STAT3 upon HDAC inhibition was protected fom degradation and induced transcription of IGF2, developing resistance to HDI treatment.; downregulation of CAV1 activates AKT pathway inducing cellular transformation; translocation of acetylated STAT3 into mitochondria after glutamate stimulation; enhanced methylation of GATA6, HDAC1/2 inhibition on and VCAM-1 expression; transcriptional increase in IGF2 expression in vorinostat-resistant NSCLC cells; SIRT1 activation inhibitss Th17 cell differentiation through STAT3 deacetylation; ER-alpha mediates both phosphorylation and acetylation of STAT3 at 1 h upon IL-6 treatment, ER-alpha recruits p300 and mediates IL-6-induced STAT3 acetylation, ER-alpha-STAT3 complex binding to the MMP2 and MMP9 promoter, leading to transcription and breast cancer cell migration; interaction between acetylated STAT3 and the CAV1 promoter -NFATC1 NFAT2 DNA-binding; Transcription factor O95644 4772 18q23 human S335-p 1869090800 GDGVPVKsRKTTLEQ activity, induced carcinogenesis, induced; cell motility, induced; transcription, induced 31730483 1 1 0 multiple sites mutatnt -MCL1 MCL1 Apoptosis; Channel, misc.; Inhibitor; Membrane protein, integral; Mitochondrial Q07820 4170 1q21.2 human K136-ub 10843917 YEPEPLGkRPAVLPL protein degradation 28522751 2 2 10 -PRKCD PKCD EC 2.7.11.13; KINASE; Kinase, protein; Nuclear receptor co-regulator; Protein kinase, AGC; Protein kinase, Ser/Thr (non-receptor); Protein kinase, tyrosine (non-receptor); Tumor suppressor Q05655 5580 3p21.1 human T295-p 4272376 AEALNQVtQRASRRS enzymatic activity, induced 19366211 3 5 1 -TBC1D1 TBC1D1 DEUBIQUITINASE; GAP; GAP, Rab; Ubiquitin-specific protease Q86TI0 23216 4p14 human S237-p 2103609 RPMRKSFsQPGLRSL molecular association, regulation transcription, inhibited 14-3-3 sigma(INDUCES) 17995453; 35061665 10 43 97 destabilizes PPARG -Adcy6 ADCY6 Adenylyl cyclase; EC 4.6.1.1; Lyase; Membrane protein, integral; Membrane protein, multi-pass; Nucleotide Metabolism - purine; Transporter; Transporter, aquaporin family AAA40678 25289 7q36 rat S744-p 467272 PNALQRLsRSIVRSR enzymatic activity, induced 11327830; 15470083 2 0 0 increases potentiation -LATS2 LATS2 EC 2.7.11.1; KINASE; Kinase, protein; Nuclear receptor co-regulator; Protein kinase, AGC; Protein kinase, Ser/Thr (non-receptor); Tumor suppressor Q9NRM7 26524 13q12.11 human T168-gl 1869341905 GLMPTPVtRRPSFEG phosphorylation carcinogenesis, induced; cell growth, induced 32513743 1 1 0 inhibits phosphorylation at LATS2-S872 and T1041 -GARS1 GARS Aminoacyl-tRNA synthetase; EC 6.1.1.14; Ligase; Mitochondrial; Translation; Translation regulation P41250 2617 7p14.3 human S704-p 1352793601 AEISELPsIVQDLAN HGTP_anticodon molecular association, regulation; intracellular localization NFkB-p100(INDUCES) 30471104 1 0 0 -TP53BP1 53BP1 DNA repair, damage; Transcription, coactivator/corepressor Q12888 7158 15q15.3 human S25-p 450163 PCLIIEDsQPESQVL apoptosis, altered 19876065 3 0 0 -Sik1 SIK EC 2.7.11.1; KINASE; Kinase, protein; Motility/polarity/chemotaxis; Protein kinase, CAMK; Protein kinase, Ser/Thr (non-receptor); Tumor suppressor Q60670 17691 17 B1|17 17.25 cM mouse T182-p 456034 KPGEPLStWCGSPPY Pkinase enzymatic activity, induced 25918234 8 0 0 regulates CAMP levels and insulin secretion -ATP7B ATP7B EC 3.6.3.54; Hydrolase; Membrane protein, integral; Membrane protein, multi-pass; Transporter; Transporter, ion channel; Vesicle P35670 540 13q14.3 human S478-p 11267008 APDILAKsPQSTRAV protein stabilization; intracellular localization 21189263 1 4 0 protein trafficking -Nr2e3 NR2E3 Nuclear receptor Q9QXZ7 23958 9 B|9 32.35 cM mouse K322-sm 7324001 KPETRGLkDPEHVEA Hormone_recep transcription, inhibited 19186166 1 0 0 -HIPK2 HIPK2 EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, CMGC; Protein kinase, Ser/Thr (non-receptor) Q9H2X6 28996 7q34 human K805-ub 3059903 TTSSRKSkQHQSSVR protein degradation 18536714 1 0 0 -RAB8A RAB8A G protein; G protein, monomeric; G protein, monomeric, Rab; Motility/polarity/chemotaxis; Oncoprotein P61006 4218 19p13.11 human T72-p 4709152 AGQERFRtITTAYYR Ras receptor recycling, inhibited; molecular association, regulation; intracellular localization; activity, inhibited endocytosis, inhibited RAB3IP(DISRUPTS); RILPL2(INDUCES) 30709905; 32017888; 33887226; 34914695 13 5 6 -Vim Vimentin Cytoskeletal; Motility/polarity/chemotaxis P20152 22352 2 A1|2 10.04 cM mouse S10-p 455451 TRSVSSSsYRRMFGG Filament_head molecular association, regulation endocytosis, induced JAG1(INDUCES) 28533359 4 11 1 transendocytosis -MYC Myc DNA-binding; Nucleolus; Oncoprotein; Transcription factor P01106 4609 8q24.21 human K413-sm 40724406 PKVVILKkATAYILS HLH protein degradation; ubiquitination transcription, inhibited 25895136 1 2 0 -Irx3 IRX3 DNA-binding P81067 16373 8 C5|8 44.55 cM mouse S389-p 1874748506 APPTLQLsPAAAAAA molecular association, regulation; intracellular localization transcription, induced IRX3(INDUCES) 34556885 1 1 0 IRX3 dimerization, nuclear translocation -TRIM9 TRIM9 iso5 EC 6.3.2.-; UBIQUITIN LIGASE; Ubiquitin conjugating system; Ubiquitin ligase Q9C026-5 114088 14q22.1 human S80-p 1046182901 EADSGYGsYGGFASA protein stabilization 29669288 1 0 0 MKK6 enhances TRIM9s phosphorylation to inhibit Its ubiquitination -BCL11B Bcl-11B C2H2-type zinc finger protein; Nuclear receptor co-regulator; Transcription regulation Q9C0K0 64919 14q32.2 human S2-p 55578701 ______MsRRKQGNP molecular association, regulation transcription, induced MTA3(DISRUPTS); MTA1(DISRUPTS) 27161321 1 0 0 no effect on SUMOylation -NAT1 NAT1 ACETYLTRANSFERASE; Acetyltransferase; EC 2.3.1.5; Secondary Metabolites Metabolism - caffeine; Xenobiotic Metabolism - drug metabolism - other enzymes P18440 9 8p22 human K100-ac 1876800100 VYSTPAKkYSTGMIH Acetyltransf_2 molecular association, regulation; enzymatic activity, inhibited PPAT(DISRUPTS) 32487734 1 0 0 acetylation inhibited the allosteric effects of ATP on NAT1 -AXL AXL EC 2.7.10.1; KINASE; Kinase, protein; Membrane protein, integral; Oncoprotein; Protein kinase, TK; Protein kinase, tyrosine (receptor) P30530 558 19q13.2 human Y821-p 451491 QEPDEILyVNMDEGG molecular association, regulation; phosphorylation carcinogenesis, induced; cell growth, induced; signaling pathway regulation GRB2(INDUCES); PLCG1(INDUCES); PIK3R2(INDUCES); PIK3R1(INDUCES) 32439698; 9178760 2 1 0 induces phosphorylation and increases levels of c-Abl, regulates c-Abl signaling -REL REL Oncoprotein; Transcription factor Q04864 5966 2p16.1 human S523-p 1980801 SMNLENPsCNSVLDP activity, induced transcription, induced 16585559 1 0 0 Double mutant S491A S494 is not responsive to NIK-induced activation of transcription at the IL-2 promoter. The comparable site to S494 in mouse Rel is an alanine, so S491 may be the more important residue. -Irgm1 IRGM EC 3.6.5.-; Endoplasmic reticulum; Hydrolase Q60766 15944 11|11 B1.2 mouse K270-ub 15492001 TLYGTYEkIVGDKVA IIGP protein degradation 35197566 1 2 1 -KCNT1 KCNT1 Channel, potassium; Membrane protein, integral; Membrane protein, multi-pass Q5JUK3 57582 9q34.3 human S407-p 27259018 VLQIPLWsQRVIYLQ activity, induced; molecular association, regulation PHACTR1(INDUCES) 27545877 2 0 0 decreases KCNT1-associated mass at the plasma membrane -Slc12a2 NKCC1 Membrane protein, integral; Membrane protein, multi-pass; Transporter; Transporter, SLC family P55012 20496 18 D3|18 32.15 cM mouse T200-p 467236 YYDTHTNtYYLRTFG AA_permease_N activity, induced; enzymatic activity, induced 20463172; 26069258 12 1 0 Enzymatic activation by SLK3 requires two threonines separated by 4 amino acids. ; Ischemic cell death -OTUD5 OTUD5 DEUBIQUITINASE; EC 3.4.19.12; Protease; Ubiquitin-specific protease Q96G74 55593 Xp11.23 human S177-p 449291 EVGAGYNsEDEYEAA protein conformation; enzymatic activity, induced 22245969; 30232733; 32071088; 33417762 5 27 2 -NBN NBS1 Cell cycle regulation; DNA repair, damage O60934 4683 8q21.3 human K698-ac 487515 VTYPGAGkLPHIIGG Nbs1_C phosphorylation cell cycle regulation; apoptosis, induced 17612497 2 1 0 inhibits phosphorylation at S343 -Ets1 Ets-1 DNA-binding; Motility/polarity/chemotaxis; Oncoprotein; Transcription factor P27577 23871 9 A4|9 17.97 cM mouse K227-sm 3656300 QTDYFAIkQEVLTPD Ets1_N_flank transcription, inhibited 16729975; 16862185 2 0 0 -Cnr1 CNR1 GPCR, family 1; Membrane protein, integral; Membrane protein, multi-pass; Receptor, GPCR P20272 25248 5q21 rat T322-p 1871994101 QKSIIIHtSEDGKVQ 7tm_1 exocytosis, inhibited 33582301 1 0 0 -OSBP2 OSBP2 Q969R2 23762 22q12.2 human S766-p 15721694 VMHSSPSsPSSDGKQ Oxysterol_BP molecular association, regulation; protein conformation signaling pathway regulation Vimentin(INDUCES) 30925160 1 4 2 -Cilk1 ICK EC 2.7.11.22; KINASE; Kinase, protein; Protein kinase, CMGC; Protein kinase, Ser/Thr (non-receptor) Q9JKV2 56542 9|9 E1 mouse Y159-p 456052 SRPPYTDyVSTRWYR Pkinase enzymatic activity, induced 15988018 1 30 435 -YAP1 YAP1 iso2 Oncoprotein; Transcription, coactivator/corepressor P46937-2 10413 11q22.1 human S381-p 3190672 TYHSRDEsTDSGLSM protein degradation; ubiquitination; activity, inhibited; phosphorylation cell differentiation, induced; cell growth, inhibited; transcription, inhibited BTRC(INDUCES) 19141641; 20048001; 23027127; 23752589 32 13 5 -NFATC3 NFAT4 DNA-binding; Transcription factor Q12968 4775 16q22.1 human K384-sm 1881937804 LGSQYPLkKDSCGDQ molecular association, regulation; intracellular localization cell growth, inhibited; cell motility, inhibited GSK3B(INDUCES) 35484132 1 0 0 DeSUMOylation of NFATc3 by SENP3 promotes PDAC cell proliferation, migration, and invasion; NFATc3 K384 deSUMOylation by SENP3 increases nuclear translocation of NFATc3 by decreasing its interaction with GSK-3? -CCDC88A girdin Actin-binding Q3V6T2 55704 2p16.1 human Y1799-p 450762 QSKDSNPyATLPRAS molecular association, regulation; intracellular localization; phosphorylation cell differentiation, inhibited; carcinogenesis, induced; cell motility, induced; cytoskeletal reorganization PIK3R1(INDUCES) 21954290; 25707853; 26887938; 32307399 5 13 137 -BRCA1 BRCA1 EC 6.3.2.-; Nuclear receptor co-regulator; Transcription, coactivator/corepressor; Tumor suppressor; UBIQUITIN LIGASE; Ubiquitin conjugating system; Ubiquitin ligase P38398 672 17q21.31 human S1497-p 448730 EPGVERSsPSKCPSL molecular association, regulation; intracellular localization cell growth, induced ATM(INDUCES) 10550055; 19683496; 21706030 7 4 2 -TAF10 TAF10 Nuclear receptor co-regulator; Transcription initiation complex Q12962 6881 11p15.4 human K189-m3 57824500 GSSRSKSkDRKYTLT transcription, induced 25959397 1 0 0 oxidation inhibits transcription -VHL VHL Tumor suppressor; UBIQUITIN LIGASE; Ubiquitin ligase P40337 7428 3p25.3 human S38-p 15573200 EESGAEEsGPEESGP protein degradation transcription, altered 20637892; 26973240 2 0 0 VHL clevaage and subsequent degradation; regulates p53 activity and degradation of HIF1A -POU5F1 Oct4 DNA-binding; Transcription factor Q01860 5460 6p21.33 human K151-m1 57951804 KELEQFAkLLKQKRI Pou molecular association, regulation transcription, induced SOX2(INDUCES) 27369080 1 1 0 -Map2k1 MEK1 EC 2.7.12.2; KINASE; Kinase, protein; Protein kinase, STE; Protein kinase, dual-specificity (non-receptor) P31938 26395 9 C|9 34.55 cM mouse T292-p 448287 ETPPRPRtPGRPLSS Pkinase molecular association, regulation; enzymatic activity, inhibited; phosphorylation cell motility, induced; cell adhesion, altered; cell growth, altered ERK2(INDUCES) 12167697; 19219045 14 6 0 required to modulate phosphorylation of MEK1 and MEK2 heterodimer -HIC1 HIC1 C2H2-type zinc finger protein; Transcription factor; Tumor suppressor Q14526 3090 17p13.3 human S713-p 1872610000 DKAAEVLsQGAHLAA DNA repair, induced 33756345 1 1 0 -TRIM21 TRIM21 EC 6.3.2.-; Ligase; UBIQUITIN LIGASE; Ubiquitin conjugating system; Ubiquitin ligase P19474 6737 11p15.4 human K385-ac 1875282500 WTIWLWNkQKYEAGT SPRY molecular association, regulation TRIM21(DISRUPTS) 32796032 1 0 0 induces the antibody-dependent intracellular neutralization (ADIN) of the nonenveloped DNA virus adenovirus (AdV) type 5 ; Hyperacetylation of TRIM21 bLocks dimerization and ubiquitinalion -RIGI RIGI EC 3.6.4.13; Hydrolase O95786 23586 9p21.1 human K115-ub 62480701 KRLQPEFkTRIIPTD CARD_2 protein degradation transcription, inhibited 27506794 1 2 0 -SIRPA SHPS1 Cell adhesion; Cell surface; Membrane protein, integral; Motility/polarity/chemotaxis; Receptor, misc. P78324 140885 20p13 human Y470-p 451114 ASEDTLTyADLDMVH molecular association, regulation; phosphorylation cell motility, induced; cell growth, induced; signaling pathway regulation CTK(INDUCES); SHP-2(INDUCES); SHP-1(INDUCES) 10842184; 18233962; 21799000 5 8 18 regulation TLR3/4-dependent cytokine production pathway; Mutation of these 4 tyrosines does not affect JAK2 binding. However, overexpression of the WT SHPS1 but not the 4 tyrosine to phenylalanine mutation reduces tyrosine phosphorylation of Jak2, STAT5B, and STAT3 and activation of Erk1/2 in response to growth hormone. Does not affect STAT3 tyrosine phosphorylation in response to LIF agonist.; induces phosphorylation of itself at Y429 and Y453, and of MAPK, regulates SHPS1- signaling -IKBKG IKKG Adaptor/scaffold; Protein kinase, regulatory subunit Q9Y6K9 8517 Xq28 human S8-p 62382604 MNRHLWKsQLCEMVQ protein stabilization transcription, induced 27929056 1 0 0 -Scimp UNQ5783 Membrane protein, integral Q3UU41 327957 11|11 B3 mouse Y120-p 464680 STEPENDyDDVEIPA SCIMP molecular association, regulation transcription, induced GRB2(INDUCES); TLR4(INDUCES); CSK(INDUCES); Syk(INDUCES); TLR2(INDUCES); BLNK(INDUCES); TLR3(INDUCES); TLR1(INDUCES) 34496234; 35337798 2 2 6 -Rab10 RAB10 G protein; G protein, monomeric; G protein, monomeric, Rab P35281 50993 6q14 rat Y6-p 473923 __MAKKTyDLLFKLL molecular association, regulation MICAL3(INDUCES); MICAL1(INDUCES) 35227894 1 5 58 -CKAP4 CKAP4 Endoplasmic reticulum; Membrane protein, integral Q07065 10970 12q23.3 human S3-p 455353 _____MPsAKQRGSK molecular association, regulation; intracellular localization; palmitoylation neural plasticity; cell growth, inhibited; cytoskeletal reorganization; transcription, altered; signaling pathway regulation DNA(INDUCES) 15703217; 22265418; 22536245 3 0 0 -SAMD4B SAMD4B Unknown function Q5PRF9 55095 19q13.2 human S642-p 21688100 SSVQRTHsLPVHSSP molecular association, regulation 14-3-3 beta(INDUCES) 21725060 1 1 3 mutation of this site prevents 14-3-3 binding (pan-14-3-3 antibody) -HMGN2 HMGN2 DNA-binding P05204 3151 1p36.11 human K18-sm 33622401 KGDKAKVkDEPQRRS HMG14_17 protein stabilization; molecular association, regulation chromatin organization, altered; transcription, induced DNA(DISRUPTS) 24872413 1 0 0 -Ahrr AHRR Transcription factor Q3U1U7 11624 13|13 C1 mouse K542-sm 6423504 LSLDVPIkMENESGS molecular association, regulation transcription, inhibited ANKRA2(INDUCES); HDAC5(INDUCES); HDAC4(INDUCES) 19251700 1 0 0 -Pln PLB Inhibitor; Membrane protein, integral P61014 18821 10|10 B3 mouse S16-p 448114 RSAIRRAsTIEMPQQ Phospholamban activity, induced; protein degradation; molecular association, regulation PPP1R3A(DISRUPTS) 11861420; 24244723; 26966065 78 15 66 -DDIT3 DDIT3 Autophagy; DNA-binding; Oncoprotein; Transcription factor P35638 1649 12q13.3 human S82-p 448091 STSQSPHsPDSSQSS transcription, altered 8650547 1 1 0 CHOP-Gal-4 chimeric protein induced a reporter gene expression. -TUBA1A TUBA1A Cytoskeletal; Motility/polarity/chemotaxis Q71U36 7846 12q13.12 human S165-p 25757493 SVDYGKKsKLEFSIY Tubulin cell cycle regulation; carcinogenesis, inhibited; cell growth, inhibited; cytoskeletal reorganization; transcription, altered 30176291 1 0 1 S165D-high expression of N-cadherin while suppressing E-cadherin protein, whereas for 165N E-cadherin remains high, and N-cadherin is decreased -KRT6A K6a Cytoskeletal P02538 3853 12q13.13 human K180-ub 12292903 KFASFIDkVRFLEQQ Filament ubiquitination 29191848 1 6 7 -ESR2 ER-beta DNA-binding; Nuclear receptor Q92731 2100 14q23.2-q23.3 human Y36-p 34425602 SIYIPSSyVDSHHEY ERbeta_N molecular association, regulation; ubiquitination cell growth, inhibited; cell motility, inhibited; transcription, induced p300(INDUCES) 24960160; 27323858 2 0 0 -SNCA SNCA Adaptor/scaffold P37840 6622 4q22.1 human S87-p 449948 KTVEGAGsIAAATGF Synuclein molecular association, regulation apoptosis, induced SNCA(DISRUPTS); SNCA(INDUCES) 16959772; 28919642; 36690898 9 1 0 induces seeding of pathological a-Syn prepared from Lewy body disease (LBD) brains and inhibits seeding of pathological a-Syn prepared from multiple system atrophy brains ; reduces SNCA binding from the membrane ; promotes intracellular SNCA inclusion formation and increases cell's cytotoxicity -Trim28 TIF1B EC 6.3.2.-; KINASE; Kinase, protein; Ligase; Nuclear receptor co-regulator; Protein kinase, atypical; SUMO LIGASE; SUMO ligase; Transcription, coactivator/corepressor; UBIQUITIN LIGASE; Ubiquitin conjugating system; Ubiquitin ligase Q62318 21849 7|7 A1 mouse S473-p 452391 SGMKRSRsGEGEVSG molecular association, regulation; intracellular localization cell cycle regulation; transcription, induced; signaling pathway regulation; transcription, altered; DNA repair, induced; cell differentiation, induced; chromatin organization, altered; cell growth, induced; transcription, inhibited HDAC11(DISRUPTS); CBX1(DISRUPTS); EHMT2(DISRUPTS) 18590578; 22205726; 25737281; 33619215; 33657380 27 117 20 increase skeletal muscle size and regulates function through RSmTOR signaling; induce hypertrophy -CDKN1A p21Cip1 Cell cycle regulation; Inhibitor P38936 1026 6p21.2 human K161-ub 9897003 KRRLIFSkRKP____ protein degradation; ubiquitination cell cycle regulation; carcinogenesis, induced; cell growth, induced; apoptosis, inhibited 13678583; 17429006; 28446751; 35732617 5 0 0 -Snap23 SNAP23 Vesicle O70377 64630 3q35 rat S95-p 455262 NRTKNFEsGKNYKAT SNAP-25 molecular association, regulation; intracellular localization exocytosis, altered STX17(INDUCES); STX1A(INDUCES) 20967886; 33213278; 37057886 14 4 2 -UBE2N UBE2N DNA repair, damage; EC 6.3.2.19; Ligase; UBIQUITIN LIGASE; Ubiquitin conjugating system; Ubiquitin ligase P61088 7334 12q22 human K92-ub 3931511 RICLDILkDKWSPAL UQ_con protein conformation 32286321 1 9 156 ubiquitination is inhibited through competing with Ub to bind MavC -FOXO3 FOXO3A Autophagy; DNA-binding; Oncoprotein; Transcription factor O43524 2309 6q21 human S12-p 9318037 PASPAPLsPLEVELD transcription, induced 29445193 2 22 14 activate mitochondrial transcription in surviving cells, while the FoxO3A-S12A/S30A mutant contributed to apoptosis induction in metabolically stressed cancer cells. -MITF MITF DNA-binding; Oncoprotein; Transcription factor O75030 4286 3p13 human K308-ub 485779 SEARALAkERQKKDN protein degradation; molecular association, regulation autophagy, induced SQSTM1(INDUCES) 35092699 2 0 0 -Ar AR DNA-binding; Nuclear receptor; Transcription factor P19091 11835 X C3|X 42.82 cM mouse S794-p 1875398900 MKALLLFsIIPVDGL Hormone_recep molecular association, regulation; intracellular localization; activity, inhibited; phosphorylation carcinogenesis, altered; transcription, inhibited; transcription, altered; signaling pathway regulation AR(INDUCES) 34715066; 36470072 2 0 0 -MAPK4 ERK4 EC 2.7.11.24; KINASE; Kinase, protein; Protein kinase, CMGC; Protein kinase, Ser/Thr (non-receptor) P31152 5596 18q21.1-q21.2 human S186-p 2228602 YSHKGYLsEGLVTKW Pkinase molecular association, regulation MAPKAPK5(INDUCES) 18248330 1 14 2 -Nr2e3 NR2E3 Nuclear receptor Q9QXZ7 23958 9 B|9 32.35 cM mouse K178-sm 7324000 ITAETCAkLEPEDAE transcription, inhibited 19186166 1 0 0 -Rab13 RAB13 G protein; G protein, monomeric; G protein, monomeric, Rab Q9DD03 68328 3 F1|3 39.21 cM mouse K46-ub 1883494501 STIGIDFkIRTVDIE molecular association, regulation GDI1(DISRUPTS) 35343654 1 0 0 Promotes the Post-Golgi Tra?cking of TLR4 and TLR9 -LAT LAT Adaptor/scaffold; Membrane protein, integral O43561 27040 16p11.2 human Y220-p 448005 SLDGSREyVNVSQEL LAT activity, induced; molecular association, regulation cytoskeletal reorganization; transcription, induced; transcription, altered SLP76(INDUCES); GRB2(INDUCES); PLCG1(INDUCES); GADS(INDUCES) 10811803; 11046020; 20460647 40 4 54 NF-AT mediated transcription; Does not regulate integrin mediated adhesion.; association of LAT-rich vesicles with surface clusters of SLP76 -EGFR EGFR EC 2.7.10.1; KINASE; Kinase, protein; Membrane protein, integral; Oncoprotein; Protein kinase, TK; Protein kinase, tyrosine (receptor) P00533 1956 7p11.2 human K708-ub 1065311 QALLRILkETEFKKI protein degradation 17940017 1 4 0 -TERF2 TRF2 DNA repair, damage; DNA-binding Q15554 7014 16q22.1 human R67-me 10338214 RASRSSGrARRGRHE cell cycle regulation; cell growth, altered 19596784 1 0 0 -CTNNB1 CTNNB1 Actin-binding; Cell adhesion; Motility/polarity/chemotaxis; Nuclear receptor co-regulator; Oncoprotein; Transcription factor P35222 1499 3p22.1 human T472-p 3653236 ICALRHLtSRHQEAE Arm apoptosis, induced; transcription, inhibited 24117889 1 1 0 -CNR1 CNR1 GPCR, family 1; Membrane protein, integral; Membrane protein, multi-pass; Receptor, GPCR P21554 1268 6q15 human T467-p 22342301 TMSVSTDtSAEAL__ molecular association, regulation CRIP1(DISRUPTS); ARRB2(DISRUPTS) 27895162 2 0 0 -USP10 USP10 DEUBIQUITINASE; EC 3.4.19.12; Protease; RNA-binding; Ubiquitin conjugating system; Ubiquitin-specific protease Q14694 9100 16q24.1 human S337-p 12483200 ASGTLPVsQPKSWAS protein stabilization; ubiquitination; intracellular localization carcinogenesis, inhibited; cell growth, altered 20096447 1 0 0 regulates p53 homeostasis -GSK3A GSK3A EC 2.7.11.1; EC 2.7.11.26; KINASE; Kinase, protein; Protein kinase, CMGC; Protein kinase, Ser/Thr (non-receptor) P49840 2931 19q13.2 human S21-p 448584 SGRARTSsFAEPGGG protein degradation; ubiquitination; enzymatic activity, inhibited carcinogenesis, induced; cell growth, induced; apoptosis, induced; apoptosis, inhibited 11035810; 11520785; 11956225; 18701488; 21530327; 21868755; 24879152; 25714023; 37495110 156 24 277 -PARP1 PARP1 DNA repair, damage; EC 2.4.2.30; Nuclear envelope; Nuclear receptor co-regulator; Nucleolus; Transferase P09874 142 1q42.12 human K23-m1 1883588000 SGRASCKkCSESIPK DNA repair, induced 35847980 1 1 0 repair of stalled replication forks -PACSIN2 PACSIN2 Adaptor/scaffold; Motility/polarity/chemotaxis Q9UNF0 11252 22q13.2 human S372-p 3215997 EDEDDTGsTVSEKDD molecular association, regulation; receptor internalization, altered neural plasticity PICK1(DISRUPTS) 23918399 1 3 0 regulates AMPAR trafficking -DEK DEK DNA replication; DNA-binding; Histone-binding; Oncoprotein; RNA splicing P35659 7913 6p22.3 human S32-p 465616 MPGPREEsEEEEDED molecular association, regulation RNA splicing, altered U2AF1(INDUCES) 16809543 3 57 43 -Rho Rhodopsin GPCR, family 1; Membrane protein, integral; Membrane protein, multi-pass; Receptor, GPCR P15409 212541 6 E3|6 53.72 cM mouse S334-p 448677 PLGDDDAsATASKTE receptor inactivation, altered 11086991 8 6 0 Mutant rhodopsins had prolonged rate of recovery with increasing number of phosphorylation sites. -CTPS1 CTPS EC 6.3.4.2; Ligase; Motility/polarity/chemotaxis; Nucleotide Metabolism - pyrimidine P17812 1503 1p34.2 human S574-p 452258 YSDRSGSsSPDSEIT activity, inhibited 17681942 1 51 5 -CNOT7 CNOT7 EC 3.1.13.4; Transcription, coactivator/corepressor Q9UIV1 29883 8p22 human K206-ac 59117700 MKSCKNLkGGLQEVA CAF1 molecular association, regulation cell differentiation, inhibited; RNA stability, inhibited RNA(INDUCES) 27635759 1 1 0 -Syngap1 SynGAP GAP; GAP, Ras Q9QUH6 192117 20p12 rat S780-p 451015 MARGLNSsMDMARLP DUF3498 activity, induced 14970204 2 6 0 -ADAM17 TACE EC 3.4.24.86; Membrane protein, integral; Motility/polarity/chemotaxis; Protease P78536 6868 2p25.1 human S819-p 449039 QRQNRVDsKETEC__ enzymatic activity, induced 20188673 3 7 1 -Cdk5r1 CDK5R1 Protein kinase, regulatory subunit P61809 12569 11 B5|11 47.94 cM mouse S33-p 13421403 HYTAVQNsKNAKDKN protein processing 20200223 1 0 0 calpain-mediated cleavage -NCOA3 SRC-3 ACETYLTRANSFERASE; Acetyltransferase; EC 2.3.1.48; Motility/polarity/chemotaxis; Nuclear receptor co-regulator; Transcription, coactivator/corepressor Q9Y6Q9 8202 20q13.12 human S1062-p 4252805 DQLHTLLsNTDATGL Nuc_rec_co-act protein stabilization; molecular association, regulation carcinogenesis, induced; transcription, induced ATF-4(INDUCES); PSMA3(DISRUPTS) DNA(INDUCES) 18313384; 31975428 2 1 1 induces binding to promoters of genes in the purine pathway; some subset of these 8 residues -MYC Myc iso1 DNA-binding; Nucleolus; Oncoprotein; Transcription factor P01106-1 4609 8q24.21 human K323-ub 21179450 RKDYPAAkRVKLDSV Myc_N protein degradation carcinogenesis, inhibited; transcription, inhibited 35296795 1 1 0 -ITGB1BP1 ICAP1 Cell adhesion; Motility/polarity/chemotaxis O14713 9270 2p25.1 human S10-p 1872961000 RKGKKRHsSSSSQSS ICAP-1_inte_bdg intracellular localization 32005669 1 0 0 regulates localization of itself and of KRIT1 -Foxp2 FOXP2 C2H2-type zinc finger protein; DNA-binding P58463 114142 6|6 A1 mouse K673-sm 56423807 HIHSIHVkEEPVIAE intracellular localization cell growth, induced; cell differentiation, induced; transcription, inhibited 27009683 1 0 0 -BCL2 Bcl-2 Apoptosis; Autophagy; Membrane protein, integral; Oncoprotein P10415 596 18q21.33 human S87-p 448396 AAAGPALsPVPPVVH molecular association, regulation; protein stabilization; ubiquitination; protein conformation; activity, inhibited apoptosis, altered; apoptosis, induced; apoptosis, inhibited BAX(INDUCES); beclin 1(DISRUPTS); PIN1(INDUCES); p53(DISRUPTS) 10567572; 10669763; 11077443; 11495898; 12039864; 15703383; 16714293; 16738310; 17097560; 18570871; 19029119; 19336399; 23272207; 25826088; 34064109 22 1 0 -Eif2ak2 PKR EC 2.7.10.2; EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, Other; Protein kinase, Ser/Thr (non-receptor); Protein kinase, tyrosine (non-receptor); Translation Q03963 19106 17 E3|17 49.56 cM mouse T414-p 448089 SRTRRTGtLQYMSPE Pkinase apoptosis, induced; translation, inhibited 34647267 15 1 0 -ACE2 ACE2 EC 3.4.17.23; Membrane protein, integral; Protease Q9BYF1 59272 Xp22.2 human S787-p 1868161400 PYASIDIsKGENNPG transcription, induced 20484496 2 0 0 activation of ERK1/2 and upregulation of CCL2by SARS-CoV VLPs -EGFR EGFR EC 2.7.10.1; KINASE; Kinase, protein; Membrane protein, integral; Oncoprotein; Protein kinase, TK; Protein kinase, tyrosine (receptor) P00533 1956 7p11.2 human R224-m2 56856901 QQCSGRCrGKSPSDC Furin-like intracellular localization; protein conformation; enzymatic activity, induced cell growth, induced 26571401 1 1 0 -RBL1 Rb-like 1 Transcription, coactivator/corepressor; Tumor suppressor P28749 5933 20q11.23 human S640-p 451296 RRDMQPLsPISVHER cell growth, altered 11884610 3 24 10 -SLAMF7 SLAMF7 Immunoglobulin superfamily; Membrane protein, integral Q9NQ25 57823 1q23.3 human Y284-p 455053 HSGENTEyDTIPHTN intracellular localization; phosphorylation 25312647 1 2 14 Y284 is needed for tyrosine phosphorylation of SHIP-1 in response to SLAMF7 engagement -ITGB7 ITGB7 Cell adhesion; Membrane protein, integral; Motility/polarity/chemotaxis; Receptor, misc. P26010 3695 12q13.13 human T784-p 464648 LYKSAITtTINPRFQ Integrin_b_cyt molecular association, regulation FLNA(DISRUPTS) 16455489 1 0 0 based on glutamate mutant of threonine site -Eef2k EEF2K EC 2.7.11.20; KINASE; Kinase, protein; Protein kinase, Ser/Thr (non-receptor); Protein kinase, atypical; Translation P70531 25435 1q36 rat S499-p 455998 RLHLPRPsAVALEVQ phosphorylation; enzymatic activity, induced 11171059; 33191388 6 9 2 induces phosphorylation of EEf2 -SMAD1 SMAD1 DNA-binding; Transcription factor Q15797 4086 4q31.21 human S239-p 25546600 DPMTQDGsQPMDTNM activity, induced; molecular association, regulation DNA repair, induced; carcinogenesis, inhibited; apoptosis, induced; transcription, induced p53(INDUCES); PPPM1A(INDUCES) 22588298 1 0 0 -Med17 MED17 Nuclear receptor co-regulator; Transcription, coactivator/corepressor Q8VCD5 234959 9|9 A2 mouse S53-p 4765330 RIDFSQGsGSEEEEA activity, induced; intracellular localization transcription, induced 28223413 1 8 0 Induced FASN promoter activity, activation of lipogenic genes, MED17 recruitment to FASN promoter -CLOCK CLOCK ACETYLTRANSFERASE; Acetyltransferase; DNA-binding; EC 2.3.1.48; Transcription factor O15516 9575 4q12 human S106-p 1881001400 DWKPTFLsNEEFTQL molecular association, regulation; intracellular localization carcinogenesis, induced; cell growth, induced; apoptosis, inhibited; transcription, inhibited Exportin-1(INDUCES); PRPS1(INDUCES); PRPS2(INDUCES); BMAL1(DISRUPTS) 36646788 1 1 0 binding to PRPS1/2 inhibits HSC70 binding to PRPS1/2 -RAC1 RAC1 G protein; G protein, monomeric; G protein, monomeric, Rho; Motility/polarity/chemotaxis P63000 5879 7p22.1 human K166-ub 12108617 ALTQRGLkTVFDEAI Ras protein degradation cell motility, inhibited 23512198 1 9 2 -Des desmin Cytoskeletal; Motility/polarity/chemotaxis P31001 13346 1 C4|1 38.85 cM mouse S8-p 478271 MSQAYSSsQRVSSYR transcription, altered; cell growth, altered 17381546 1 0 0 important for cardiomyogenesis -Stat5a STAT5A DNA-binding; Motility/polarity/chemotaxis; Oncoprotein; Transcription factor P42230 20850 11 D|11 63.77 cM mouse S725-p 448749 TYMDQAPsPVVCPQP activity, induced; molecular association, regulation; activity, inhibited; phosphorylation carcinogenesis, altered; cell growth, induced DNA(DISRUPTS) 10744710; 12091337; 12529425; 20508164; 24263804 19 1 0 -VCL Vinculin iso2 Cell adhesion; Cytoskeletal; Motility/polarity/chemotaxis P18206-2 7414 10q22.2 human Y1065-p 454003 WVRKTPWyQ______ Vinculin activity, induced; molecular association, regulation; protein conformation cell adhesion, altered; cytoskeletal reorganization BSG(INDUCES); talin 1(INDUCES) 20678470; 24338477; 25033086 9 1 22 -Dnm2 DYN2 EC 3.6.5.5; Hydrolase; Microtubule-binding; Motility/polarity/chemotaxis; Vesicle P39054 13430 9 A3|9 7.79 cM mouse S764-p 3191449 LQNTSGHsPTPQRRP enzymatic activity, inhibited signaling pathway regulation 32510172 5 9 0 phosphorylation of this site inhibits Fc gamma R-mediated phagocytosis -MFF MFF Membrane protein, integral; Mitochondrial Q9GZY8 56947 2q36.3 human K302-ub 41529300 SLRRQIIkLNRRLQL Miff protein degradation 31112535 2 1 0 PARK2 mediated lysosomal degradation of MFF -LRP2 LRP2 Membrane protein, integral; Motility/polarity/chemotaxis; Receptor, misc. P98164 4036 2q31.1 human T4478-p 767906 SENGNGVtFRSGADL receptor internalization, altered; receptor recycling, altered 17555532 1 0 0 -MAFA MAFA DNA-binding; Oncoprotein; Transcription factor; Tumor suppressor Q8NHW3 389692 8q24.3 human T53-p 1320402 PPGSLSStPLSTPCS protein degradation; molecular association, regulation; ubiquitination carcinogenesis, induced; transcription, induced PCAF(INDUCES) 18042454 4 1 0 -CIITA CIITA DNA-binding; EC 2.7.11.1; KINASE; Protein kinase, Ser/Thr (non-receptor); Transcription, coactivator/corepressor P33076 4261 16p13.13 human S286-p 2902204 TSPDRPGsTSPFAPS intracellular localization transcription, altered 15210796 1 0 0 -PRKAA1 AMPKA1 Autophagy; EC 2.7.11.1; EC 2.7.11.26; EC 2.7.11.27; EC 2.7.11.31; KINASE; Kinase, protein; Protein kinase, CAMK; Protein kinase, Ser/Thr (non-receptor) Q13131 5562 5p13.1 human T490-p 3195170 EAKSGTAtPQRSGSV AdenylateSensor protein conformation; phosphorylation transcription, induced; autophagy, inhibited; translation, induced 23623684 1 32 56 induces phosphorylation of T482 and S486 and inhibits phosphorylation at T172 and of ACC and Raptor -PIP5K1C PIP5K1C Carbohydrate Metabolism - inositol phosphate; EC 2.7.1.68; Kinase, lipid; Motility/polarity/chemotaxis O60331 23396 19p13.3 human S453-p 15721933 KNSSLKSsPSKKGRG enzymatic activity, inhibited 30040488 1 3 0 induces cell invasion, decreases fibronectin secretion -SPP1 osteopontin Secreted; Secreted, signal peptide P10451 6696 4q22.1 human S123-p 455738 DSHQSDEsHHSDESD Osteopontin molecular association, regulation; activity, inhibited Other(INDUCES) 19775205 1 5 0 peptide with phosphorylated S117, S120, S123, S126 and S129 has increased binding to hydroxyapatite, and inhibits bone mineralization in vivo and in vitro -RANBP2 RANBP2 Adaptor/scaffold; EC 5.2.1.8; EC 6.3.2.-; Ligase; Nuclear export; Nucleoporin; SUMO LIGASE; SUMO conjugating system; SUMO ligase P49792 5903 2q13 human T2153-p 3191215 LLDIPLQtPHKLVDT molecular association, regulation; intracellular localization BICD2(INDUCES) 26051540 1 25 19 targets BicD2 to the NE of RGP cells to induce apical nuclear migration -PRKDC DNAPK DNA repair, damage; EC 2.7.11.1; KINASE; Kinase, protein; Nucleolus; Protein kinase, Ser/Thr (non-receptor); Protein kinase, atypical P78527 5591 8q11.21 human T2609-p 448710 LTPMFVEtQASQGTL DNAPKcs_CC5 molecular association, regulation; intracellular localization; protein conformation; enzymatic activity, induced cell cycle regulation; carcinogenesis, induced; DNA repair, induced; chromatin organization, altered; DNA repair, altered; cell growth, altered SLC25A5(DISRUPTS) DNA(DISRUPTS) 12231622; 17189255; 18037521; 19244120; 20406977; 24687855; 24844881; 31980741; 32868446; 34249431; 35974014; 36727301 36 8 22 -CRMP1 CRMP-1 Cell development/differentiation; Cytoskeletal; Hydrolase Q14194 1400 4p16.2 human T101-p 11539300 RAALVGGtTMIIDHV Amidohydro_1 cell cycle regulation 19799413 1 1 0 -HMGN1 HMGN1 DNA-binding; Nuclear receptor co-regulator P05114 3150 21q22.2 human S21-p 454111 KEEPKRRsARLSAKP HMG14_17 molecular association, regulation; intracellular localization transcription, altered 14-3-3 zeta(INDUCES); SRF(DISRUPTS) DNA(DISRUPTS) 10739259; 12215538; 17938209 4 9 14 -Map3k4 MEKK4 EC 2.7.11.25; KINASE; Kinase, protein; Protein kinase, STE; Protein kinase, Ser/Thr (non-receptor) O08648 26407 17 8.42 cM|17 A1 mouse S1241-p 4695872 RSLSRHSsPTEERDE MEKK4_N molecular association, regulation; enzymatic activity, induced GADD45A(INDUCES) 27358404 1 16 1 -NDRG1 NDRG1 Cell development/differentiation; Vesicle Q92597 10397 8q24.22 human T346-p 454245 GTRSRSHtSEGTRSR phosphorylation carcinogenesis, induced; carcinogenesis, inhibited; carcinogenesis, altered; cell differentiation, induced; cell growth, induced; apoptosis, inhibited; signaling pathway regulation 20416281; 21719465; 27451907; 33003561; 37298315 26 13 246 -MAPT Tau iso3 ACETYLTRANSFERASE; Acetyltransferase; Cytoskeletal P10636-3 4137 17q21.31 human S105-p 447927 GDRSGYSsPGSPGTP molecular association, regulation cytoskeletal reorganization 10747907 91 33 33 regulates association with membrane -PKP3 plakophilin 3 Cell adhesion Q9Y446 11187 11p15.5 human S285-p 4782043 APSVRSLsLSLADSG molecular association, regulation; intracellular localization cell adhesion, induced; cell motility, inhibited 14-3-3 sigma(INDUCES) 24124604; 29678907 2 8 0 strong plasma membrane association with or without 14-3-3 sigma overexpression in WT cells; Mutants unable to associate with 14-3-3 sigma, display decreased adhesion and increased motility. -LIFR LIFR Membrane protein, integral; Receptor, cytokine P42702 3977 5p13.1 human S887-p 4707125 KALQFQKsVCEGSSA protein conformation 28122243 1 6 2 ESC pluripotency in vivo -Htr2a 5-HT(2A) GPCR, family 1; Membrane protein, integral; Membrane protein, multi-pass; Receptor, GPCR P14842 29595 15q11 rat S314-p 6057801 AGRRTMQsISNEQKA 7tm_1 receptor desensitization, altered; activity, inhibited 19103592 1 0 0 -Myod1 MyoD DNA-binding; RNA splicing; Transcription factor P10085 17927 7 B3|7 30.03 cM mouse S237-p 3188104 YSEAAREsRPGKSAA Myf5 activity, induced transcription, altered 10838091 1 0 0 -PHLPP1 PHLPP EC 3.1.3.16; PHOSPHATASE; Protein phosphatase, Ser/Thr (non-receptor); Tumor suppressor O60346 23239 18q21.33 human S336-p 27454806 FVGGPVSsPRAPRPV cell cycle regulation 33397691 1 7 0 -POLI POLI DNA repair, damage; EC 2.7.7.7; Transferase Q9UNA4 11201 18q21.2 human K729-ub 50771309 KELLAEWkRAGSDFH protein degradation 26370087 1 2 0 -MUC1 MUC1 Actin-binding; Cell adhesion; Membrane protein, integral; Motility/polarity/chemotaxis; Nuclear receptor co-regulator; Tumor suppressor P15941 4582 1q22 human Y1243-p 454879 NGGSSLSyTNPAVAA molecular association, regulation; intracellular localization; receptor internalization, altered GRB2(INDUCES); Abl(INDUCES) 15471854; 16888623 3 5 79 MUC1 blocks binding of Abl to 14-3-3 proteins, Abl phosphorylates MUC1 on Y1243; Y1203 and Y1243 are both required for efficient mucin 1 endocytosis -Lcp2 SLP76 Adaptor/scaffold Q60787 16822 11|11 A4 mouse T341-p 15415128 LPSMSSNtFPSRSVQ molecular association, regulation 14-3-3 zeta(INDUCES) 35061003 0 3 18 -DAXX DAXX Apoptosis; Nuclear receptor co-regulator; Nucleolus; Transcription, coactivator/corepressor Q9UER7 1616 6p21.32 human S176-p 3214944 TNAENTAsQSPRTRG protein stabilization; ubiquitination apoptosis, induced 19789334; 19789335 2 0 0 required for TNF alpha -dependent accumulation of Daxx in cells ; phosphorylation induces K63-linked polyubiquitination of DAXX at K122 -Nufip2 82-FIP RNA processing; RNA-binding; Translation Q5F2E7 68564 11|11 B5 mouse S114-p 3204054 ISLKSLSsDEATNPI NUFIP2 carcinogenesis, induced; translation, induced 33972660 1 13 0 -H2BC3 H2B DNA-binding P33778 3018 6p22.2 human K5-ac 458955 ___PEPSkSAPAPKK Histone cell cycle regulation; carcinogenesis, induced; chromatin organization, altered; transcription, induced; transcription, altered 16283522; 19883641 7 7 115 -Id2 ID2 DNA-binding; Transcription, coactivator/corepressor P41136 15902 12 A1.3|12 8.57 cM mouse S5-p 451265 ___MKAFsPVRSVRK intracellular localization cell cycle regulation; apoptosis, altered; cell growth, altered 19609365 4 6 0 Phosphorylated Id2 is localized to the nucleus. -Nfe2l2 NRF2 DNA-binding; Transcription factor Q60795 18024 2 C3|2 44.75 cM mouse S550-p 10292703 HLLKRRLsTLYLEVF bZIP_Maf intracellular localization transcription, induced 27161318 3 2 0 nuclear accumulation -LRP6 LRP6 Membrane protein, integral; Receptor, misc. O75581 4040 12p13.2 human T1548-p 21009100 YAPSRRMtSVATAKG molecular association, regulation; intracellular localization G-alpha(s)(INDUCES) 21406690 1 0 0 mutation impairs G-alpha-s movement to plasma membrane -Hnf4a HNF4 alpha DNA-binding; Nuclear receptor; Transcription factor P22449 25735 3q42 rat S87-p 478421 CKGFFRRsVRKNHMY zf-C4 protein degradation; intracellular localization transcription, altered DNA(DISRUPTS) 17389749 1 0 0 S87D mutation impairs nuclear localization. -NABP2 OBFC2B Cell cycle regulation; DNA repair, damage Q9BQ15 79035 12q13.3 human K94-sm 1877008702 GRGGDLQkIGEFCMV tRNA_anti-codon protein stabilization; molecular association, regulation apoptosis, induced NBS1(INDUCES) 32576812 1 0 0 recruitment of the MRN complex to DSB sites, sumoylation enhances the sensitivity of cancer cells to DNA damage agents -IRAK1 IRAK1 EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, Ser/Thr (non-receptor); Protein kinase, TKL P51617 3654 Xq28 human T387-p 447721 RTQTVRGtLAYLPEE Pkinase molecular association, regulation; phosphorylation; enzymatic activity, induced signaling pathway regulation TRAF6(INDUCES) 14625308; 31511642 5 1 0 induces MAPK and NF-kB signaling pathways by inducing phosphorylation of JNK and ERK -KCNJ1 ROMK Channel, potassium; Membrane protein, integral; Membrane protein, multi-pass P48048 3758 11q24.3 human S44-p 449605 RQRARLVsKDGRCNI IRK protein processing; activity, inhibited 15987778; 18571730 9 0 0 -Tdg TDG DNA repair, damage; EC 3.2.2.29; Hydrolase; Nuclear receptor co-regulator P56581 21665 10 C1|10 39.72 cM mouse K70-ac 458993 EPAPEAPkRRKRKPR molecular association, regulation; acetylation DNA repair, induced; chromatin organization, altered; transcription, induced APE1(DISRUPTS) 11864601 1 0 0 histone acetylation -CENPQ CENPQ Q7L2Z9 55166 6p12.3 human S255-p 40245504 SSQMKSMsTFIEEAY CENP-Q molecular association, regulation; intracellular localization DNA(DISRUPTS) 25670858 1 1 0 CENPQ phosphorylation promotes the delocalization of the PBIP1-CENPQ complex from kinetochores -RAD52 RAD52 DNA repair, damage P43351 5893 12p13.33 human K133-ac 971232903 YGVSEGLkSKALSLE Rad52_Rad22 molecular association, regulation; intracellular localization DNA repair, induced RFA2(INDUCES); RPA3(INDUCES); RAD51(INDUCES); RPA1(INDUCES) 29590107 1 1 0 accumulation of RAD52 at DSB sites -Prkaa1 AMPKA1 Autophagy; EC 2.7.11.1; EC 2.7.11.26; EC 2.7.11.27; EC 2.7.11.31; KINASE; Kinase, protein; Protein kinase, CAMK; Protein kinase, Ser/Thr (non-receptor) Q5EG47 105787 15|15 A1 mouse S172-p 15407586 KIADFGLsNMMSDGE Pkinase enzymatic activity, induced 33400924 8 1 4 -Wasl N-WASP Adaptor/scaffold; Motility/polarity/chemotaxis O08816 682507 4q22 rat T202-p 23003803 LTKADIGtPSNFQHI PBD molecular association, regulation; protein conformation cytoskeletal reorganization 22250195 1 1 0 inhibits actin polymerization in vitro; inhibits the filopodia promoting activity of N-WASP -Kcnj3 GIRK1 Channel, potassium; Membrane protein, integral; Membrane protein, multi-pass P63251 50599 3q21 rat Y12-p 457610 RRKFGDDyQVVTTSS activity, inhibited 10833508 5 0 0 -Ehmt2 EHMT2 Amino Acid Metabolism - lysine degradation; EC 2.1.1.43; METHYLTRANSFERASE; Methyltransferase; Methyltransferase, protein lysine Q9Z148 110147 17 B1|17 18.45 cM mouse K167-m2 1458625 IVLGHATkSFPSSPS molecular association, regulation HP1 alpha(INDUCES); CBX3(INDUCES) 17707231 1 2 0 -TSC2 TSC2 Cell cycle regulation; GAP; GAP, misc.; Nuclear receptor co-regulator; Tumor suppressor P49815 7249 16p13.3 human T1462-p 448546 GLRPRGYtISDSAPS activity, inhibited; phosphorylation cell cycle regulation; carcinogenesis, induced; carcinogenesis, inhibited; apoptosis, induced; signaling pathway regulation; transcription, altered; autophagy, induced; cell growth, induced; apoptosis, inhibited 15342917; 16702951; 21893193; 23142783; 27451907; 33273660; 35154579; 35670018; 37160904 64 14 48 regulates mTOR and downstream signaling -JAK2 JAK2 EC 2.7.10.2; KINASE; Kinase, protein; Oncoprotein; Protein kinase, TK; Protein kinase, tyrosine (non-receptor) O60674 3717 9p24.1 human K970-ub 1873147100 GMEYLGTkRYIHRDL PK_Tyr_Ser-Thr phosphorylation; enzymatic activity, induced transcription, induced; signaling pathway regulation 28676638 1 0 0 JAK2/STAT5 signal axis -PKM PKM Carbohydrate Metabolism - glycolysis and gluconeogenesis; Carbohydrate Metabolism - pyruvate; EC 2.7.1.40; KINASE; Kinase, other; Mitochondrial; Nucleotide Metabolism - purine P14618 5315 15q23 human S37-p 476070 MCRLDIDsPPITARN activity, induced; molecular association, regulation; intracellular localization; enzymatic activity, altered; phosphorylation carcinogenesis, induced; cell motility, induced; cell growth, induced; apoptosis, inhibited; transcription, induced; transcription, altered; transcription, inhibited CTNNB1(DISRUPTS); PKM(INDUCES); ERK2(INDUCES); ERK1(INDUCES); PKM(DISRUPTS); PIN1(INDUCES); PPP1R26(INDUCES) Other(INDUCES) 23178880; 25446258; 27323830; 27485204; 29229835; 32078667; 32989054; 34185676; 34966685; 35292107; 35790734 17 62 6 -PYCARD PYCARD Adaptor/scaffold; Tumor suppressor Q9ULZ3 29108 16p11.2 human Y137-p 3920078 EWLLDALyGKVLTDE CARD activity, induced signaling pathway regulation 31333677 1 0 1 important for NLRP2 inflammasome complex formation and function -FOXO1 FOXO1A DNA-binding; Nuclear receptor co-regulator; Oncoprotein; Transcription factor Q12778 2308 13q14.11 human S394-p 12607401 LTVSTQSsPGTMMQQ intracellular localization transcription, altered 20061393 1 0 0 multiple site mutant (8A) -KCNMB4 KCNMB4 Channel, potassium; Membrane protein, integral; Membrane protein, multi-pass Q86W47 27345 12q15 human T11-p 451271 LRVAYEYtEAEDKSI CaKB activity, inhibited 11790768 1 0 0 regulates slowpoke K(+) channel kinetics -CLDN4 Claudin-4 Cytoskeletal; Membrane protein, integral; Membrane protein, multi-pass O14493 1364 7q11.23 human S194-p 4199301 PRTDKPYsAKYSAAR intracellular localization cytoskeletal reorganization 18786529 2 1 1 -KIF2A KIF2A Microtubule-binding; Motor O00139 3796 5q12.1 human T554-p 40240801 ANRVKELtVDPTAAG intracellular localization cytoskeletal reorganization 25660017 1 0 0 similar temporal and spatial localization; microtubule depolymerization, disassemble primary cilia -MAPT Tau iso8 ACETYLTRANSFERASE; Acetyltransferase; Cytoskeletal P10636-8 4137 17q21.31 human K281-ac 1873575602 KVQIINKkLDLSNVQ Tubulin-binding intracellular localization; phosphorylation cytoskeletal reorganization 27356871; 28855586 5 2 0 -CDC25C CDC25C EC 3.1.3.48; Motility/polarity/chemotaxis; PHOSPHATASE; Protein phosphatase, dual-specificity P30307 995 5q31.2 human S263-p 486328 LCLKKTVsLCDITIT M-inducer_phosp intracellular localization 17662724 1 7 3 negatively regulates translocation from cytoplasm to nucleus -FOS Fos DNA-binding; Motility/polarity/chemotaxis; Oncoprotein; Transcription factor P01100 2353 14q24.3 human S32-p 470080 DSLSYYHsPADSFSS protein stabilization; molecular association, regulation UBR1(DISRUPTS) 17018293 4 0 0 -NAT10 ALP ACETYLTRANSFERASE; Acetyltransferase; EC 2.3.1.-; Nucleolus Q9H0A0 55226 11p13 human K426-ac 466140 TGRSLSLkLIQQLRQ Helicase_RecD enzymatic activity, induced transcription, induced 27993683 1 6 18 -Dab1 DAB1 Adaptor/scaffold P97318 13131 4 C6|4 47.79 cM mouse Y198-p 447629 EDVEDPVyQYIVFEA molecular association, regulation; intracellular localization neural plasticity; cell differentiation, induced; cell motility, altered; cytoskeletal reorganization Src(INDUCES); SOCS1(INDUCES); PIK3R1(INDUCES) 14517291; 19796633; 22586277 11 1 0 alternatively spliced variants -Hnf4a HNF4 alpha DNA-binding; Nuclear receptor; Transcription factor P49698 15378 2 H3|2 84.32 cM mouse S313-p 449926 GKIKRLRsQVQVSLE Hormone_recep carcinogenesis, inhibited; cell differentiation, induced 34616001 5 3 0 -Golga2 GM130 Cytoskeletal Q62839 64528 3p12 rat S37-p 454438 REYQQKNsPGVPAGA cell cycle regulation 20699666 4 18 1 -KAT2B PCAF ACETYLTRANSFERASE; Acetyltransferase; EC 2.3.1.48; Nuclear receptor co-regulator Q92831 8850 3p24.3 human K428-ac 458985 LEANPGEkRKMTDSH enzymatic activity, induced 12888487 1 0 0 in vitro -Zc3hav1 ZAP RNA-binding; Transferase Q8K3Y6 252832 4q22 rat S262-p 1870336230 HNSLEFLsPVVSPLG activity, induced 22514281 1 0 0 -CIITA CIITA DNA-binding; EC 2.7.11.1; KINASE; Protein kinase, Ser/Thr (non-receptor); Transcription, coactivator/corepressor P33076 4261 16p13.13 human K144-ac 458926 EVGQKSQkRPFPEEL intracellular localization transcription, induced 11046145 1 0 0 nuclear localization -RHOA RHOA G protein; G protein, monomeric; G protein, monomeric, Rho; Motility/polarity/chemotaxis; Oncoprotein P61586 387 3p21.31 human S188-p 449035 ARRGKKKsGCLVL__ protein stabilization; molecular association, regulation; enzymatic activity, inhibited; intracellular localization; activity, inhibited; phosphorylation cell differentiation, induced; cell motility, induced; apoptosis, inhibited; cytoskeletal reorganization; endocytosis, inhibited KRas iso2(INDUCES); PKN1(INDUCES); RhoGDI alpha(INDUCES); ROCK1(DISRUPTS); Diaphanous-1(INDUCES) 11162591; 12654918; 15890975; 16109481; 20591975; 21572420; 34088899; 34497151; 34551282 17 0 0 induces AKT phosphorylation, inhibits MLC phosphorylation -ANAPC1 APC1 Cell cycle regulation; Ubiquitin conjugating system Q9H1A4 64682 2q13 human S373-p 455826 VQRFNISsHNQSPKR activity, induced 27120157 2 5 0 -Rorc RORC iso2 DNA-binding; Nuclear receptor; Transcription factor P51450-2 19885 3|3 F2.1 mouse S484-p 139835701 PLYKELFsTDVESPE cell differentiation, inhibited; transcription, inhibited 28667162 1 1 0 -MAP3K5 ASK1 EC 2.7.11.25; KINASE; Kinase, protein; Protein kinase, STE; Protein kinase, Ser/Thr (non-receptor) Q99683 4217 6q23.3 human S83-p 447735 ATRGRGSsVGGGSRR enzymatic activity, inhibited; enzymatic activity, induced; phosphorylation carcinogenesis, induced; apoptosis, altered; apoptosis, inhibited; signaling pathway regulation; transcription, altered 11154276; 12697749; 14500571; 15782121; 16532036; 18794113; 19749799; 23608533; 26912789; 30205811 16 2 6 regulates ASK1-MAPK pathway -COIL coilin Oxidoreductase P38432 8161 17q22 human S202-p 10336301 KKAKNPKsPKVQAVK Coilin_N intracellular localization 9013710 1 0 0 S202A mutant is localized to nucloplasmic coiled bodies, while S202D is localized to intranucleolar domains. Phosphorylation may regulate SnRNP-nucleolar interactions. -SRC Src EC 2.7.10.2; KINASE; Kinase, protein; Oncoprotein; Protein kinase, TK; Protein kinase, tyrosine (non-receptor) P00523 396442 chicken S12-p 448230 KSKPKDPsQRRRSLE molecular association, regulation; phosphorylation cell growth, altered PKCD(DISRUPTS) 2474754; 9148947 5 1 1 Mutation of S16 increases phosphorylation at S12 -BAD BAD Apoptosis Q92934 572 11q13.1 human S75-p 447860 EIRSRHSsYPAGTED Bcl-2_BAD activity, induced; molecular association, regulation; activity, inhibited carcinogenesis, induced; apoptosis, altered; apoptosis, induced; transcription, altered; apoptosis, inhibited; cell adhesion, altered; transcription, inhibited; cell growth, altered 14-3-3 beta(INDUCES); Bcl-2(DISRUPTS); Bcl-xL(DISRUPTS) 10558990; 10611223; 10976111; 11085518; 12897059; 12970779; 14678993; 15121878; 15226424; 15972258; 17670745; 18246127; 18794113; 19154409; 20566643; 21187157; 21419810; 22096607; 25681438; 26366732; 33755959; 34138895 129 22 172 -Cav3 caveolin-3 Cell development/differentiation; Dystrophin complex; Extracellular matrix; Motility/polarity/chemotaxis P51638 29161 4q41 rat K38-sm 25087000 NINEDIVkVDFEDVI Caveolin receptor desensitization, altered 21362625 1 0 0 -Lpin1 LPIN1 EC 3.1.3.4; Phosphatase, lipid Q91ZP3 14245 12 A1.1|12 7.9 cM mouse S483-p 471356 VGGSGIDsGVESTSD molecular association, regulation BTRC(INDUCES) 28049764 2 9 0 -HSP90AA1 HSP90A Chaperone; Heat shock protein P07900 3320 14q32.31 human Y38-p 15229603 SLIINTFySNKEIFL molecular association, regulation apoptosis, inhibited Src(INDUCES); AHSA1(INDUCES); RAF1(INDUCES); HER2(INDUCES) 20159553 1 0 33 interaction with HSP90A client proteins; Silencing of Wee1 sensitizes cells to apoptosis induced by HSP90A inhibitor. -SOX11 SOX11 DNA-binding; Transcription factor P35716 6664 2p25.2 human K91-sm 1881173700 GKRWKMLkDSEKIPF sumoylation cell growth, induced 33441400 1 0 0 in vitro and in vivo K91A mutant induces RGC (retinal ganglion cell) cell death and optic nerve regeneration -MYC Myc DNA-binding; Nucleolus; Oncoprotein; Transcription factor P01106 4609 8q24.21 human T415-p 450962 VVILKKAtAYILSVQ HLH molecular association, regulation carcinogenesis, inhibited; cell growth, inhibited; cell differentiation, induced; transcription, induced MAX(DISRUPTS) DNA(INDUCES); DNA(DISRUPTS) 22020439; 25326649; 26678338 6 0 0 repression of YAP/TAZ activity -NCOA1 SRC-1 ACETYLTRANSFERASE; Acetyltransferase; DNA-binding; EC 2.3.1.48; Nuclear receptor co-regulator; Oncoprotein; Transcription, coactivator/corepressor Q15788 8648 2p23.3 human K774-sm 2407404 SLDDVKVkVEKKEQM intracellular localization transcription, induced PR(INDUCES) 12529333 1 0 0 -SSBP3 SSBP3 Cell cycle regulation; DNA-binding; Transcription regulation Q9BWW4 23648 1p32.3 human Y25-p 1806901 EKLALYVyEYLLHVG activity, induced; intracellular localization transcription, induced 18080319 1 0 0 -MAPT Tau iso8 ACETYLTRANSFERASE; Acetyltransferase; Cytoskeletal P10636-8 4137 17q21.31 human K340-sm 3829800 GGGQVEVkSEKLDFK Tubulin-binding protein stabilization; ubiquitination; phosphorylation 25378699 2 0 0 induces phosphorylation of itself at multiple sites and inhibits its ubiquitination -GMNN Geminin Cell cycle regulation; Motility/polarity/chemotaxis O75496 51053 6p22.3 human T203-p 475945 EGTVSSStDAKPCI_ apoptosis, altered 17261582 1 0 0 regulates geminin cleavage by caspase-3 -PPARG PPAR-gamma DNA-binding; Nuclear receptor; Transcription factor P37231 5468 3p25.2 human K107-sm 3617602 QEYQSAIkVEPASPP PPARgamma_N protein degradation cell differentiation, inhibited; carcinogenesis, inhibited; cell growth, inhibited; transcription, induced; transcription, altered; transcription, inhibited 15229330; 15507114; 25409419; 26244663; 29137280 15 0 0 transcription of a subset of PPAR-gamma target genes involved in lipid metabolism -IGF1R IGF1R EC 2.7.10.1; KINASE; Kinase, protein; Membrane protein, integral; Protein kinase, TK; Protein kinase, tyrosine (receptor) P08069 3480 15q26.3 human Y980-p 448390 YASVNPEyFSAADVY activity, induced; phosphorylation cell cycle regulation; cell differentiation, altered; apoptosis, altered; cell growth, altered 10746631; 10786694; 7834637 8 0 7 -PALLD palladin Cytoskeletal; Motility/polarity/chemotaxis Q8WX93 23022 4q32.3 human S688-p 18013438 APRSAPPsPPFPPPP molecular association, regulation cell motility, inhibited Abl(DISRUPTS) 22216253 1 6 0 -H4-16 H4 DNA-binding NP_001139343 530773 cow K16-ac 458960 GLGKGGAkRHRKVLR methylation cell cycle regulation 18698155 106 26 531 complex relationship of acetylation and methylation of CpG dinucleotides on DNA, during development of gametogenesis and embryogenesis -MAP3K20 ZAK EC 2.7.11.25; KINASE; Kinase, protein; Protein kinase, Ser/Thr (non-receptor); Protein kinase, TKL Q9NYL2 51776 2q31.1 human T162-p 455378 SRFHNHTtHMSLVGT PK_Tyr_Ser-Thr enzymatic activity, induced 15342622 1 0 0 -NFATC4 NFAT3 DNA-binding; Transcription factor Q14934 4776 14q12 human S259-p 31859079 APGPTPAsPRPASPC cell growth, induced; transcription, induced 27893713 1 1 0 -TPPP TPPP Cytoskeletal O94811 11076 5p15.33 human S107-p 31094519 FSKIKGKsCRTITFE p25-alpha acetylation; phosphorylation transcription, induced 23727580 1 0 0 decreases B-Catennin phosphorylation and acetylation and induces its expression -SPDEF SPDEF DNA-binding; Motility/polarity/chemotaxis; Nuclear receptor co-regulator; Transcription factor O95238 25803 6p21.31 human S243-p 54165902 TDSEVDSsCSGQPIH protein degradation cell motility, induced 26885618 1 0 0 enhances migration and invasion of prostate cancer cells -Nfil3 E4BP4 DNA-binding; Transcription factor O08750 18030 13 B1|13 27.68 cM mouse S301-p 470506 VPKGPIHsPVELQRV Vert_IL3-reg_TF transcription, inhibited 29311361 1 29 13 NK cell production inhibited -TP53 p53 Activator; DNA-binding; Motility/polarity/chemotaxis; Nuclear receptor co-regulator; Transcription factor; Tumor suppressor P04637 7157 17p13.1 human K373-ne 12067101 SSHLKSKkGQSTSRH transcription, inhibited 15242646 1 0 0 -Crebbp CBP ACETYLTRANSFERASE; Acetyltransferase; DNA-binding; EC 2.3.1.48; Motility/polarity/chemotaxis; Nuclear receptor co-regulator; Transcription, coactivator/corepressor P45481 12914 16 A1|16 2.4 cM mouse K1596-ac 461371 KNNKKTNkNKSSISR HAT_KAT11 acetylation 28630323 1 6 255 autoacetylation of CBP K1596 (autoregulatory loop (AL) of CBP) has a negative regulatory effect on acetylation of H3K27 -NFE2L2 NRF2 DNA-binding; Transcription factor Q16236 4780 2q31.2 human K508-ac 7106327 IRRRGKNkVAAQNCR bZIP_Maf molecular association, regulation transcription, induced DNA(INDUCES) 19273602 1 1 0 -LGALS3 galectin-3 Cell surface; Extracellular matrix; Motility/polarity/chemotaxis P17931 3958 14q22.3 human S6-p 450131 __MADNFsLHDALSG molecular association, regulation; intracellular localization; protein conformation cell cycle regulation; apoptosis, inhibited MUC1(DISRUPTS); LAMA1(DISRUPTS) 10961987; 11724777; 15121858; 24269589; 26911284 8 2 0 Expression of S5 mutants of galectin-3 failed to protect cells from cisplatin-induced death and poly(ADP-ribose) polymerase from degradation when compared with wild type galectin-3.; may allosterically influence carbohydrate binding to the S-face; little effect on interactions between the NT and CRD F-face; Phosphorylation of S6 and S12 In N-terminal promotes association with carbohydrate recognition domain (CRD), while phosphorylation of Y107 and Y118 attenuates this interaction. -PCGF1 PCGF1 EC 6.3.2.-; Ubiquitin conjugating system Q9BSM1 84759 2p13.1 human Y109-p 2897401 RVMQDIVyKLVPGLQ transcription, inhibited 15620699 1 0 0 -STK38 NDR1 EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, AGC; Protein kinase, Ser/Thr (non-receptor) Q15208 11329 6p21.31 human S10-p 22553319 MTGSTPCsSMSNHTK enzymatic activity, inhibited; phosphorylation signaling pathway regulation 22142472 1 0 0 primes phosphorylation at S6 and T7, induces JNK phosphorylation, regulates cell death through JNK signaling -RAP1GAP RAP1GAP GAP; GAP, Ras; Motility/polarity/chemotaxis P47736 5909 1p36.12 human S525-p 450258 AGQKTPDsGHVSQEP protein degradation; molecular association, regulation; ubiquitination cell growth, induced BTRC(INDUCES) 14660640; 25329897 2 1 0 Rap1GAP degradation is required for cell proliferation. -Pebp1 RKIP Lipid-binding; Protein kinase, regulatory subunit P31044 29542 12q16 rat S52-p 3189664 QVMNRPSsISWDGLD PBP phosphorylation 35696587 2 35 11 inhibits phosphorylation at S51 -Csf3r GCSFR Membrane protein, integral; Receptor, cytokine P40223 12986 4 D2.2|4 59.77 cM mouse Y788-p 449311 PTPSPKSyENIWFHS activity, induced; phosphorylation 7489718; 9032244 5 0 0 JNK activation and SHC phosphorylation; Mutation of Y788 abolished the ability of the receptor to stimulate tyrosine phosphorylation of a cellular protein with an Mr of 54 kDa. -DPYSL2 CRMP-2 Microtubule-binding; Motility/polarity/chemotaxis Q16555 1808 8p21.2 human K374-sm 31094501 DKAVVTGkMDENQFV Amidohydro_1 receptor internalization, induced; intracellular localization 33478555 6 0 0 Numb, Nedd4-2 and Eps15 compex is necessary for non-SUMOylated CRMP2-mediated internalization of sodium channels in vivo -Rbl2 Rb-like 2 Transcription, coactivator/corepressor; Tumor suppressor Q64700 19651 8 C4|8 44.25 cM mouse K128-ac 15207810 SLIEFFNkMKKWEDM DUF3452 phosphorylation 23029429 2 1 0 enhances phosphorylation of Rb-like2 -EGFR EGFR EC 2.7.10.1; KINASE; Kinase, protein; Membrane protein, integral; Oncoprotein; Protein kinase, TK; Protein kinase, tyrosine (receptor) P00533 1956 7p11.2 human Y1016-p 448055 DVVDADEyLIPQQGF activity, induced; molecular association, regulation; receptor internalization, altered; intracellular localization; protein conformation; phosphorylation; enzymatic activity, induced endocytosis, altered; carcinogenesis, inhibited; cell motility, altered; cell adhesion, altered; signaling pathway regulation SOS1(INDUCES); RASA1(INDUCES); VAV2(INDUCES); SHP-2(INDUCES); GRB2(DISRUPTS) 10069801; 10653583; 12454019; 1314835; 14560030; 15592458; 15708852; 16729043; 17575160; 19002495; 21787862; 31197039; 7506413; 8408058; 9020117 45 7 12 -Zc3hav1 ZAP RNA-binding; Transferase Q8K3Y6 252832 4q22 rat S270-p 3203916 PVVSPLGsGPPSPDV activity, induced 22514281 1 20 0 -Add2 ADD2 Cytoskeletal; Motility/polarity/chemotaxis Q05764 24171 4q34 rat S712-p 449802 KKKFRTPsFLKKSKK intracellular localization cytoskeletal reorganization 9679146 8 58 159 -LHX3 LHX3 DNA-binding; Transcription factor Q9UBR4 8022 9q34.3 human S238-p 455299 MKRSRGGsKSDKDSV activity, induced transcription, induced 15517599 1 0 0 no change in binding to DNA or to certain proteins (NLI, PIT1, or MRG1) -Ppargc1b PGC-1 beta Nuclear receptor co-regulator; Transcription, coactivator/corepressor Q8VHJ7 170826 18|18 E1 mouse K933-ac 7761211 TRSKRGQkHGFITFR RRM_1 intracellular localization transcription, inhibited 19491097 1 1 0 -Chmp5 CHMP5 Cell cycle regulation; Vesicle Q9D7S9 76959 4|4 A5 mouse S26-p 87391001 DCIGTVDsRAESIDK Snf7 protein stabilization USP8(INDUCES) 28553951 1 1 0 -MRTFA MKL1 Oncoprotein; Transcription, coactivator/corepressor Q969V6 57591 22q13.1-q13.2 human S454-p 467355 TGSTPPVsPTPSERS intracellular localization transcription, altered 18694962; 22139079 3 44 15 stimulates MKL1 binding to G-actin and its nuclear export -JUNB JunB Motility/polarity/chemotaxis; Oncoprotein; Transcription factor P17275 3726 19p13.13 human T255-p 465822 EARSRDAtPPVSPIN Jun protein degradation FBXW7(INDUCES) 22710716 1 51 16 mitosis progression and chromatid cohesion -G6PD G6PD Carbohydrate Metabolism - pentose phosphate pathway; Cell development/differentiation; EC 1.1.1.49; Other Amino Acids Metabolism - glutathione; Oxidoreductase P11413 2539 Xq28 human Y507-p 451668 GFQYEGTyKWVNPHK G6PD_C cell motility, altered 19359662 2 28 773 modulates Akt activity -NFE2L2 NRF2 DNA-binding; Transcription factor Q16236 4780 2q31.2 human Y576-p 460703 RDEDGKPySPSEYSL protein degradation; ubiquitination; intracellular localization apoptosis, induced; transcription, inhibited 21097520; 21690096; 32295843 6 1 1 -Rps6kb1 p70S6K iso2 EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, AGC; Protein kinase, Ser/Thr (non-receptor); Translation P67999-2 83840 10q26 rat S17-p 450117 DQPEDAGsEDELEEG molecular association, regulation Exportin-1(INDUCES) 16895915 2 1 6 -SHOX SHOX DNA-binding; Transcription factor O15266 6473 X;Y human S106-p 457680 EKREDVKsEDEDGQT cell cycle regulation; transcription, induced 16325853 1 1 0 -ECE1 ECE1 iso3 Cell surface; EC 3.4.24.71; Membrane protein, integral; Protease; Vesicle P42892-3 1889 1p36.12 human K6-ub 1877956802 __MMSTYkRATLDEE protein degradation cell growth, inhibited 31788944 1 0 0 K6R mutant enhances stability, tumor growth and EMT invasiveness -CYTH2 cytohesin 2 GEF; GEF, ARF Q99418 9266 19q13.33 human S392-p 450661 AARKKRIsVKKKQEQ protein stabilization; molecular association, regulation; intracellular localization; protein conformation ATP6V0A2(DISRUPTS) 10531036; 20153292; 24083777 4 1 11 increases both the helicity and stability of the C-terminus, formation of salt bridges between p-S392 and Arg390,Lys395, and Lys396 -BBC3 PUMA Apoptosis; Mitochondrial Q9BXH1 27113 19q13.32 human Y152-p 29674707 ADDLNAQyERRRQEE PUMA protein degradation; intracellular localization cell growth, induced; apoptosis, inhibited 24236056 1 0 0 -HSP90AA1 HSP90A Chaperone; Heat shock protein P07900 3320 14q32.31 human K478-ac 2884404 GDEMVSLkDYCTRMK HSP90 molecular association, regulation CHIP(DISRUPTS); TEBP(DISRUPTS); HSP70(DISRUPTS); HSP40(DISRUPTS) 18559531 1 2 0 -EZH2 EZH2 EC 2.1.1.43; METHYLTRANSFERASE; Methyltransferase; Methyltransferase, protein lysine Q15910 2146 7q36.1 human Y244-p 59087901 AEELKEKyKELTEQQ PRC2_HTH_1 molecular association, regulation; protein conformation cell growth, induced; transcription, induced POLR2A(INDUCES); PRRC2C iso2(INDUCES) DNA(INDUCES) 27297789; 32631994 2 0 0 -DNAJB1 HSP40 Chaperone; Nucleolus P25685 3337 19p13.12 human S151-p 23099871 VNFGRSRsAQEPARK transcription, inhibited 24309468 1 1 1 -CREBBP CBP ACETYLTRANSFERASE; Acetyltransferase; DNA-binding; EC 2.3.1.48; Motility/polarity/chemotaxis; Nuclear receptor co-regulator; Transcription, coactivator/corepressor Q92793 1387 16p13.3 human R742-me 475951 PQAPMGPrAASPMNH molecular association, regulation; acetylation; enzymatic activity, induced transcription, induced; signaling pathway regulation RAC3(INDUCES); ER-alpha(INDUCES) DNA(INDUCES) 12374746; 21632823 2 0 0 steroid hormone signaling, GRIP1 and steroid hormone-induced transcription; induces CBP autoacetylation -LRRK1 LRRK1 EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, Ser/Thr (non-receptor); Protein kinase, TKL Q38SD2 79705 15q26.3 human T1427-p 41694202 GALGVEGtPGYQAPE Pkinase molecular association, regulation; enzymatic activity, induced; phosphorylation cytoskeletal reorganization WDR34(INDUCES); WDR60(INDUCES) 26192437; 36254578 2 0 0 -Abcc9 ABCC9 Channel, potassium; Membrane protein, integral; Membrane protein, multi-pass; Transporter; Transporter, ABC family Q63563 25560 4q44 rat S636-p 41608700 KKHTGVQsKPINRKQ activity, induced; protein stabilization; protein conformation 26198630 1 1 0 -ATF4 ATF-4 DNA-binding; Transcription factor P18848 468 22q13.1 human S219-p 448436 DTPSDNDsGICMSPE protein degradation; protein stabilization; molecular association, regulation transcription, altered BRD8 iso2(INDUCES); FBW1B(INDUCES) 11238952; 18052253; 21706477 4 0 0 -Gab1 GAB1 Adaptor/scaffold; Motility/polarity/chemotaxis Q9QYY0 14388 8|8 C2 mouse S552-p 454074 ELQAPVRsPITRSFA activity, induced; molecular association, regulation; intracellular localization; protein conformation GAB1(DISRUPTS) 19050043; 25460044; 28365441 3 9 0 -Pde4d PDE4D iso6 EC 3.1.4.53; Nucleotide Metabolism - purine; Phosphodiesterase P14270-6 24627 rat S585-p 451090 YQSTIPQsPSPAPDD cell cycle regulation 24815749 7 3 0 -Dab1 DAB1 iso2 Adaptor/scaffold P97318-2 13131 4 C6|4 47.79 cM mouse T476-p 479419 LTPVTSTtPSTNSPP phosphorylation 16529723 1 0 0 inhibits tyrosine phosphorylation -YAP1 YAP1 Oncoprotein; Transcription, coactivator/corepressor P46937 10413 11q22.1 human S164-p 471933 AQHLRQSsFEIPDDV cell growth, induced; cell growth, inhibited; apoptosis, induced; cell motility, altered; transcription, inhibited 24658687; 28416665 13 16 45 sensitivity to gemcitabine -MRTFA MKL1 Oncoprotein; Transcription, coactivator/corepressor Q969V6 57591 22q13.1-q13.2 human K499-sm 2407402 SPLQILVkEEGPRAG transcription, inhibited 16098147 1 1 0 -FOXM1 FOXM1 iso2 DNA-binding; Transcription factor Q08050-2 2305 12p13.33 human K463-sm 31898503 PHLARPIkVESPPLE protein degradation transcription, inhibited 25533473 2 0 0 -Cd79a Ig-alpha Immunoglobulin superfamily; Membrane protein, integral P11911 12518 7 A3|7 13.49 cM mouse Y204-p 447752 SRGLQGTyQDVGNLH activity, induced; molecular association, regulation; intracellular localization cell differentiation, altered; signaling pathway regulation; cell growth, altered GRB2(INDUCES); BLNK(INDUCES); VAV1(INDUCES) 11449366; 11859098; 11909947; 16860757; 17163454 6 5 30 Ca(2+) signaling; promotes B cell activation, proliferation and differentiation. -CSF3R GCSFR Membrane protein, integral; Receptor, cytokine Q99062 1441 1p34.3 human Y787-p 449311 LTPSPKSyENLWFQA activity, induced; molecular association, regulation; activity, inhibited; phosphorylation cell growth, altered SHIP(INDUCES); SHC1(INDUCES) 15470047; 8547634 5 0 0 SHIP and Shc phosphorylation -LASP1 Lasp-1 Actin-binding; Motility/polarity/chemotaxis O77506 100009568 rabbit S99-p 450464 KNKGRGFsVVADTPE intracellular localization cytoskeletal reorganization 12432067 1 6 1 -Cacna1c CACNA1C iso5 Channel, calcium; Membrane protein, integral; Membrane protein, multi-pass Q0PCR6 12288 6 F1|6 55.86 cM mouse T1704-p 17620920 RAISGDLtAEEELDK CAC1F_C activity, induced 24218620 9 1 0 increased channel current and contractility in response to beta-adrenergic stimulation, exercise capacity and cardiac function in vivo -FPR2 FPR2 GPCR, family 1; Membrane protein, integral; Membrane protein, multi-pass; Motility/polarity/chemotaxis; Receptor, GPCR P25090 2358 19q13.41 human S236-p 3176601 HKKGMIKsSRPLRVL 7tm_1 receptor desensitization, altered 11063592 1 0 0 downregulates PLA2 and PLD activation -ETV5 ERM DNA-binding; Transcription factor P41161 2119 3q27.2 human K468-sm 2887210 DNQRPFLkAESECHL transcription, inhibited 18243147 1 0 0 -Dll1 DLL1 Cell development/differentiation; Membrane protein, integral; Motility/polarity/chemotaxis Q61483 13388 17 A2|17 8.95 cM mouse T638-p 31012807 SFKVRYPtVDYNLVR transcription, induced 24449764 1 1 0 mutant shows increased stability -NONO NONO Nuclear receptor co-regulator; Nucleolus; RNA splicing; RNA-binding Q15233 4841 Xq13.1 human K371-ac 9263619 RRQQEGFkGTFPDAR transcription, induced 35843094 1 1 7 transcription of the IL-8 gene -EPM2A laforin EC 3.1.3.16; EC 3.1.3.48; Motility/polarity/chemotaxis; PHOSPHATASE; Protein phosphatase, dual-specificity O95278 7957 6q24.3 human S25-p 20583300 PELLVVGsRPELGRW CBM_20 protein stabilization; molecular association, regulation; enzymatic activity, induced laforin(INDUCES); NHLRC1(INDUCES); PPP1CA(INDUCES); AMPKA2(INDUCES) 21728993 1 1 0 -ZNF281 ZNF281 C2H2-type zinc finger protein; DNA-binding; Transcription factor Q9Y2X9 23528 1q32.1 human S807-p 460884 STGFQIPsQELASQI intracellular localization DNA repair, induced 31570788 1 3 4 -TRPS1 TRPS1 C2H2-type zinc finger protein; Transcription factor Q9UHF7 7227 8q23.3 human K1201-sm 3278911 EGPLNVVkTEKVDRS transcription, inhibited 17391059 2 4 0 -PTPN1 PTP1B EC 3.1.3.48; Motility/polarity/chemotaxis; PHOSPHATASE; Phosphatase; Protein phosphatase, tyrosine (non-receptor) P18031 5770 20q13.13 human S286-p 27528603 KFIMGDSsVQDQWKE enzymatic activity, induced apoptosis, induced 23348582 1 0 0 S286 phosphorylation promotes mitotic cell death. -MSH5 MSH5 Cell cycle regulation; DNA repair, damage; DNA replication O43196 4439 6p21.33 human Y742-p 29570701 GNDLVFFyQVCEGVA MutS_V molecular association, regulation DNA repair, induced DNA(INDUCES) 24023853 1 0 0 -Slc5a5 SLC5A5 Membrane protein, integral; Membrane protein, multi-pass; Transporter; Transporter, SLC family Q63008 114613 16p14 rat S43-p 990307 LARGGQRsADDFFTG activity, induced 17913707 1 1 1 -ERBB3 HER3 EC 2.7.10.1; KINASE; Kinase, protein; Membrane protein, integral; Oncoprotein; Protein kinase, TK; Protein kinase, tyrosine (receptor) P21860 2065 12q13.2 human Y1328-p 451650 SAFDNPDyWHSRLFP molecular association, regulation SHC1(INDUCES) 16729043 4 17 216 -EIF4E EIF4E Translation; Translation initiation P06730 1977 4q23 human K159-ub 486277 AVVNVRAkGDKIAIW IF4E protein degradation; molecular association, regulation; phosphorylation translation, altered eIF4G(DISRUPTS) 16720573 1 0 0 inhibits phosphorylation -SLC6A3 DAT Membrane protein, integral; Membrane protein, multi-pass; Transporter; Transporter, SLC family Q01959 6531 5p15.33 human T48-p 1385533601 QLTSSTLtNPRQSPV palmitoylation 30587577 1 1 0 Increased palmitoylation in dephosphomimetic mutant. -ZEB2 ZEB2 C2H2-type zinc finger protein; DNA-binding; Motility/polarity/chemotaxis; Transcription, coactivator/corepressor O60315 9839 2q22.3 human K866-sm 3726901 PLNLTFIkKEFSNSN molecular association, regulation transcription, induced CTBP1(DISRUPTS) 16061479 1 1 0 -SENP3 SENP3 DESUMOYLASE; EC 3.4.22.68; Nucleolus; Protease; Sumo-specific protease Q9H4L4 26168 17p13.1 human S26-p 4957737 GIPPAYSsPRRERLR molecular association, regulation; intracellular localization NPM1(INDUCES) 25288641 1 4 15 ribosome biogenesis-28S rRNA maturation -Cttn Cortactin Actin-binding; Cytoskeletal; Motility/polarity/chemotaxis Q60598 13043 7|7 F5 mouse K235-ac 461721 YVKGFGGkFGVQTDR HS1_rep molecular association, regulation; acetylation; intracellular localization DIP2A(INDUCES) 31600191 2 4 21 DIP2A regulates spine morphology and synaptic transmission through acetylation of cortactin; Interaction of DIP2A-cortactin is required for acetylated cortactin; acetylation mimetic cortactin rescues the repetitive behaviors in Dip2a KO mice; acetylation alleviated abnormal PSD95 clustering at the spine head in DIP2A KO neurons -GJA8 GJA8 Channel, misc.; Membrane protein, integral; Membrane protein, multi-pass P48165 2703 1q21.2 human S258-p 2574911 SLHSIAVsSIQKAKG protein stabilization; intracellular localization 35120923 1 2 0 -LMNB1 Lamin B1 Cytoskeletal P20700 4001 5q23.2 human T575-p 3177672 ELFHQQGtPRASNRS molecular association, regulation; intracellular localization Oct1(DISRUPTS) 28542436 1 32 57 -Npm1 NPM1 Nucleolus; Oncoprotein; RNA-binding; Translation Q61937 18148 11|11 A4 mouse S88-p 4169620 MSVQPTVsLGGFEIT Nucleoplasmin protein conformation 24616519 2 12 0 -MARK2 MARK2 EC 2.7.11.1; EC 2.7.11.26; KINASE; Kinase, protein; Protein kinase, CAMK; Protein kinase, Ser/Thr (non-receptor) Q7KZI7 2011 11q13.1 human S400-p 5635600 HKVQRSVsANPKQRR molecular association, regulation; intracellular localization 14-3-3 beta(INDUCES) 19011111 1 5 0 -Hnf4a HNF4 alpha DNA-binding; Nuclear receptor; Transcription factor P49698 15378 2 H3|2 84.32 cM mouse S318-p 20510201 LRSQVQVsLEDYIND Hormone_recep molecular association, regulation SSU72(INDUCES) 34616001 2 1 0 -KRT6A K6a Cytoskeletal P02538 3853 12q13.13 human K194-ub 15492068 QNKVLETkWTLLQEQ Filament ubiquitination 29191848 1 1 1 -CETN2 CETN2 Calcium-binding; Cell cycle regulation; DNA repair, damage P41208 1069 Xq28 human S170-p 448199 LRIMKKTsLY_____ molecular association, regulation; protein stabilization; protein conformation cell cycle regulation; cell growth, altered XPC(DISRUPTS) 11279195; 21731694; 31202846 4 0 0 centrosome amplification -Irak1bp1 IRAK1BP1 Transcription regulation Q9ESJ7 65099 9|9 E2 mouse T246-p 12524605 AASKVFItFEVKGKE SIMPL intracellular localization transcription, altered 17079333 1 0 1 nuclear localization -H2-Eb1 HLA-DRB1 Membrane protein, integral P18468 14969 17 B1|17 17.98 cM mouse K225-ub 3597309 QSTSAQNkMLSGVGG receptor recycling, inhibited; protein degradation endocytosis, altered 16785530; 17255932 3 0 0 -BCAR1 P130Cas Adaptor/scaffold; Motility/polarity/chemotaxis P56945 9564 16q23.1 human S437-p 8069100 SSTGSTRsSQSASSL intracellular localization cell motility, altered 19454314 1 1 0 -STARD10 STARD10 Q9Y365 10809 11q13.4 human S284-p 483984 GGAGGEGsDDDTSLT activity, inhibited 17561512 1 30 6 Inhibits lipid transfer activity in vitro -Prkcd PKCD EC 2.7.11.13; KINASE; Kinase, protein; Nuclear receptor co-regulator; Protein kinase, AGC; Protein kinase, Ser/Thr (non-receptor); Protein kinase, tyrosine (non-receptor); Tumor suppressor P28867 18753 14 B|14 18.82 cM mouse Y311-p 447573 TTESVGIyQGFEKKP intracellular localization; phosphorylation; enzymatic activity, induced apoptosis, induced 27531930; 33932405; 33995031 44 60 1707 -RBBP8 CtIP EC 3.1.-.-; Transcription, coactivator/corepressor Q99708 5932 18q11.2 human T731-p 1868101002 LEDMFDRtTHEEYES cell cycle regulation; DNA repair, inhibited 30202980 1 0 0 supress DSB end resection -MACF1 ACF7 Actin-binding; Cytoskeletal; Motility/polarity/chemotaxis Q9UPN3 23499 1p34.3 human S7230-p 18507014 KPSSRAAsPTRSSSS intracellular localization cell motility, induced; cytoskeletal reorganization 21295697 1 3 2 inhibits localization along microtubules, alters organization of microtubules, regulates skin wound repair, SC migration -ZFPM1 FOG1 C2H2-type zinc finger protein; Transcription regulation Q8IX07 161882 16q24.2 human K463-sm 14988612 PAAPRSIkVEAVEEP molecular association, regulation CTBP1(INDUCES) 20587419 1 0 0 -Tbc1d1 TBC1D1 DEUBIQUITINASE; GAP; GAP, Rab; Ubiquitin-specific protease Q60949 57915 5 C3.1|5 32.8 cM mouse T499-p 2228808 NRAKRSLtESLESIL activity, inhibited 19740738 2 7 2 reduces inhibitory effect on TBC1D1 on GLUT4 translocation -Gata4 GATA4 Motility/polarity/chemotaxis; Transcription factor P46152 54254 15p12 rat S261-p 450013 IKPQRRLsASRRVGL activity, induced; molecular association, regulation cell growth, induced; transcription, induced p300(INDUCES); NKX2-5(INDUCES) DNA(INDUCES) 12670947; 22227582 9 1 1 -FBXL2 FBXL2 UBIQUITIN LIGASE; Ubiquitin ligase Q9UKC9 25827 3p22.3 human T404-p 15278700 HAYFAPVtPPTAVAG molecular association, regulation; ubiquitination FBXO3(INDUCES) 23542741; 27010866 2 4 2 ApaG domain alone is necessary, but not sufficient for binding and degradation of FBxl2; induces ubiquitination of FBXL2-K201; T404 FBLX2 phosphorylated peptide does not bind FBxo3 ApaG domain in vitro -PDE3A PDE3A EC 3.1.4.17; Membrane protein, integral; Membrane protein, multi-pass; Nucleotide Metabolism - purine; Phosphodiesterase Q14432 5139 12p12.2 human S428-p 456821 IPKRLRRsLPPGLLR molecular association, regulation; enzymatic activity, induced cell growth, induced 14-3-3 beta(INDUCES); 14-3-3 sigma(INDUCES) 16153182; 19261611; 25961942 5 11 1 -IL6ST gp130 Membrane protein, integral; Receptor, cytokine P40189 3572 5q11.2 human Y915-p 448183 QTVRQGGyMPQ____ cell cycle regulation; transcription, altered 10623831 2 1 7 -RPS3 RPS3 Apoptosis; EC 4.2.99.18; RNA-binding; Ribosomal; Translation P23396 6188 11q13.4 human T42-p 455909 SGVEVRVtPTRTEII KH_2 intracellular localization 17560175 2 0 0 translocation to nucleus -UBXN7 UBXN7 Unknown function O94888 26043 3q29 human K99-ub 6778629 EPLFGAPkRRRPARS protein degradation; ubiquitination signaling pathway regulation 36096451 1 11 39 HBV X protein promotes K48-linked ubiquitination of UBXN7 protein at K99, UBXN7 up-regulated ubiquitination of IKKB and inhibits NF-kB signaling pathway by promoting the degradation of IKK-beta -CCDC88A girdin Actin-binding Q3V6T2 55704 2p16.1 human S1690-p 27811900 LQQFLEEsNKLTSVQ molecular association, regulation; phosphorylation cell growth, induced; cytoskeletal reorganization; cell motility, inhibited G-alpha(s)(INDUCES); G-alpha i3(DISRUPTS); G-alpha i1(DISRUPTS) 23509302; 27621449; 31363053 3 0 0 Akt phosphorylation inhibited -HK1 HK1 Carbohydrate Metabolism - amino sugar and nucleotide sugar; Carbohydrate Metabolism - fructose and mannose; Carbohydrate Metabolism - galactose; Carbohydrate Metabolism - glycolysis and gluconeogenesis; Carbohydrate Metabolism - starch and sucrose; EC 2.7.1.1; Kinase, other; Mitochondrial P19367 3098 10q22.1 human Y732-p 462391 YDRLVDEySLNAGKQ Hexokinase_2 protein conformation; enzymatic activity, induced cell motility, induced; cell growth, induced 28054552 1 2 35 promote cell migration and invasion; tumour incidence and metastasis -Prkab1 AMPKB1 Autophagy; KINASE; Protein kinase, regulatory subunit P80386 83803 12q16 rat S182-p 448110 DVSELSSsPPGPYHQ intracellular localization 11171104 4 17 1 -WWTR1 TAZ Oncoprotein; Transcription, coactivator/corepressor Q9GZV5 25937 3q25.1 human T326-p 41594201 GCYSVPTtPEDFLSN protein degradation; activity, inhibited carcinogenesis, inhibited; cell growth, inhibited; cell motility, inhibited; transcription, inhibited 26183396; 26375055 2 0 0 -CDC25C CDC25C EC 3.1.3.48; Motility/polarity/chemotaxis; PHOSPHATASE; Protein phosphatase, dual-specificity P30307 995 5q31.2 human T48-p 448419 VCPDVPRtPVGKFLG protein degradation; molecular association, regulation cell cycle regulation; cell adhesion, altered NEDD4(INDUCES); PIN1(INDUCES) 10037602; 24710276; 8119945 7 10 15 -CARD9 CARD9 Adaptor/scaffold Q9H257 64170 9q34.3 human K125-ub 50760800 LLMTEVMkLQKKVQD activity, induced transcription, induced; signaling pathway regulation 26488816 1 0 0 regulates anti-fungal innate immune signaling via C-type lectin receptor -Pdx1 PDX1 DNA-binding; Transcription factor P52947 29535 12p11 rat Y68-p 458821 SPPDISPyEVPPLAD activity, induced; molecular association, regulation transcription, induced p300(INDUCES) 15001545 1 0 0 -SMAD6 SMAD6 DNA-binding; Transcription factor O43541 4091 15q22.31 human R82-m2 1880719800 RGAQGAGrRRRAGGP molecular association, regulation; intracellular localization cell differentiation, inhibited SMAD1(INDUCES) 33667543 2 0 0 Disrupts SMAD1-SMAD4 complex formation,required for nuclear localization of SMAD1, promotes cell invasion, inhibits osteogenic differentiation -IRF5 IRF5 DNA-binding; Transcription factor Q13568 3663 7q32.1 human K411-ub 4666601 PDRKPREkKLITVQV IRF-3 molecular association, regulation; ubiquitination; intracellular localization transcription, induced; transcription, inhibited LYN(INDUCES) 18824541; 27521268 2 1 0 pro-inflammatory cytokine gene transcription; nuclear translocation; inhibition of IRF5 activation by Lyn requires their physical Interaction, Lyn inhibits IRF5 ubiquitination and phosphorylation by protecting IRF5 from each of PTM enzymes -Pdpk1 PDK1 EC 2.7.11.1; KINASE; Kinase, protein; Nuclear receptor co-regulator; Protein kinase, AGC; Protein kinase, Ser/Thr (non-receptor) Q9Z2A0 18607 17|17 A3.3 mouse S244-p 447693 SKQARANsFVGTAQY Pkinase enzymatic activity, induced cell growth, induced 11570885; 14623982; 35210408 63 95 264 -Irs1 IRS1 Adaptor/scaffold; Motility/polarity/chemotaxis P35569 16367 1 C5|1 42.0 cM mouse S307-p 447558 TESITATsPASMVGG phosphorylation neural plasticity; cell differentiation, inhibited; signaling pathway regulation 10722755; 21852229; 32075735; 34694913 77 14 0 -AKT1 Akt1 EC 2.7.11.1; KINASE; Kinase, protein; Oncoprotein; Protein kinase, AGC; Protein kinase, Ser/Thr (non-receptor) P31749 207 14q32.33 human S129-p 450019 SGSPSDNsGAEEMEV molecular association, regulation; phosphorylation; enzymatic activity, induced cell cycle regulation; carcinogenesis, induced; cell motility, induced; cell growth, induced; apoptosis, inhibited; transcription, induced; signaling pathway regulation palladin(INDUCES) 15818404; 21159648; 21735093; 24769357; 36243702 13 48 2 -DDX17 DDX17 iso3 EC 3.6.4.13; Helicase; Nuclear receptor co-regulator; Nucleolus; RNA processing; RNA-binding; Spliceosome; Transcription, coactivator/corepressor Q92841-3 10521 22q13.1 human K29-ac 15211507 GGGGLPPkKFGNPGE protein stabilization; molecular association, regulation cell cycle regulation; apoptosis, inhibited HDAC3(INDUCES); HDAC1(INDUCES) 20663877 1 1 0 -Trpv1 TRPV1 Channel, cation; Membrane protein, integral; Membrane protein, multi-pass; Receptor, misc. O35433 83810 10q24 rat T370-p 455383 RHLSRKFtEWAYGPV molecular association, regulation; receptor desensitization, altered ARRB2 iso2(INDUCES) 15691846; 23360390 4 0 0 -Frs2 FRS2 Adaptor/scaffold Q8C180 327826 10|10 D2 mouse Y196-p 448153 AEEQVHTyVNTTGVQ molecular association, regulation GRB2(INDUCES) 9182757 7 3 9 -G6pd2 G6PD-2 EC 1.1.1.49; Oxidoreductase P97324 14380 5 C3.1|5 31.99 cM mouse T10-p 1869062303 EQVTLSRtQVCGILR enzymatic activity, induced carcinogenesis, induced; cell growth, induced 32259365 1 0 0 -Yap1 YAP1 Oncoprotein; Transcription, coactivator/corepressor P46938 22601 9|9 A1 mouse Y392-p 473004 SGLSMSSySIPRTPD protein stabilization; molecular association, regulation; intracellular localization transcription, induced; signaling pathway regulation TEAD1(INDUCES); TEAD4(INDUCES); Src iso1(INDUCES); gp130(INDUCES) 23708000; 25731159; 31018132; 33474722 23 3 4 -LPO LPO EC 1.11.1.7; Oxidoreductase; Secreted; Secreted, signal peptide ABN41562 100860761 goat S315-p 1779806 LVYGSEPsLASRLRN An_peroxidase enzymatic activity, induced 18191143 2 0 0 facilitates calcium ion binding -Foxo1 FOXO1A DNA-binding; Nuclear receptor co-regulator; Oncoprotein; Transcription factor Q9R1E0 56458 3 C|3 23.19 cM mouse S253-p 448075 SPRRRAAsMDNNSKF protein degradation; molecular association, regulation; ubiquitination; intracellular localization; activity, inhibited; phosphorylation cell cycle regulation; apoptosis, induced; cell motility, inhibited; transcription, induced; signaling pathway regulation; cell growth, induced; apoptosis, inhibited; transcription, inhibited 10377430; 10698940; 11375271; 20921625; 22848439; 25119572; 26929406; 28559285; 33503413; 33530926; 33786575; 34556581; 35197460; 35878408; 36870057 98 8 48 -CDKN2A p16-INK4A Cell cycle regulation; Nucleolus; Tumor suppressor P42771 1029 9p21.3 human S8-p 448830 MEPAAGSsMEPSADW protein stabilization; activity, inhibited 20152798; 21270107 3 0 0 -CSF2RB CSF2RB Membrane protein, integral; Receptor, cytokine P32927 1439 22q12.3 human S601-p 448463 LGPPHSRsLPDILGQ activity, induced; molecular association, regulation; phosphorylation apoptosis, inhibited; transcription, altered 14-3-3 beta(INDUCES); PIK3R1(INDUCES) 10477722; 10949031; 12920017 6 1 0 S601 is important for NF-kB and Akt activation, and Bcl-2 expression. -Map2 MAP2 iso3 Cytoskeletal; Motility/polarity/chemotaxis P15146-3 25595 9q32 rat K107-ac 62495519 AEAVAVLkGEQEKEA cytoskeletal reorganization 28002468 1 1 0 -Rims1 RIMS1 Adaptor/scaffold; Vesicle Q9JIR4 84556 9q13 rat S241-p 455663 RLQERSRsQTPLSTA molecular association, regulation 14-3-3 beta(INDUCES); 14-3-3 gamma(INDUCES); 14-3-3 eta(INDUCES) 12871946 1 0 0 -CTTN Cortactin Actin-binding; Cytoskeletal; Motility/polarity/chemotaxis Q14247 2017 11q13.3 human S113-p 465664 SKLSKHCsQVDSVRG HS1_rep molecular association, regulation carcinogenesis, induced; cell motility, induced; cytoskeletal reorganization ARPC1B(INDUCES); ARPC2(INDUCES) 24859002; 30562756 3 16 17 destabilization of invadopodia structures through serine phosphorylation of cortactin; Arp2/3 complex binding; S113A mutant dissasembled invadopodia only 30% of the time -Fndc5 FNDC5 Membrane protein, integral Q8K4Z2 384061 4|4 D2.2 mouse K177-ac 1881215703 CRQYDIIkDNEPNNN ubiquitination 33754067 1 0 0 SIRT2-dependent deacetylation and deubiquitination increases stability -STK3 MST2 Autophagy; EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, STE; Protein kinase, Ser/Thr (non-receptor) Q13188 6788 8q22.2 human T336-p 3801535 TSVESVGtMRATSTM ubiquitination; intracellular localization; phosphorylation cell cycle regulation; carcinogenesis, induced 37739411 1 8 33 TRIM69 regulates centrosome dynamics and mitotic progression and centrosome amplification, regulates centrosome clustering, promotes triple-negative breast cancer; TRIM69A regulates MST2 ubiquitination and intracellular localization -Cers2 LASS2 DNA-binding; Membrane protein, integral; Membrane protein, multi-pass; Transferase Q924Z4 76893 3|3 F2.1 mouse T346-p 469769 ERSDREEtESSEGEE enzymatic activity, induced 26887952 1 42 217 -Flot2 FLOT2 Cell adhesion Q9Z2S9 83764 10q25 rat Y163-p 475941 DVYDKVDyLSSLGKT Band_7 molecular association, regulation; intracellular localization cell motility, altered; cytoskeletal reorganization FLOT1(INDUCES) 17213334; 19318123 4 3 36 -PTPN3 PTPN3 EC 3.1.3.48; Motility/polarity/chemotaxis; PHOSPHATASE; Protein phosphatase, tyrosine (non-receptor) P26045 5774 9q31.3 human S835-p 451192 VRSLRVDsEPVLVHC Y_phosphatase molecular association, regulation 14-3-3 beta(INDUCES) 9341175 1 0 1 -KRT12 K12 Cytoskeletal Q99456 3859 17q21.2 human K189-ub 52490402 LIEDLRNkIISASIG Filament protein degradation 26676607 0 1 0 -Mdm2 MDM2 EC 6.3.2.-; EC 6.3.2.19; Inhibitor; Ligase; NEDDYLATION LIGASE; Neddylation Ligase; Nucleolus; Oncoprotein; UBIQUITIN LIGASE; Ubiquitin conjugating system; Ubiquitin ligase P23804 17246 10 D2|10 66.32 cM mouse S183-p 448131 RHRKRRRsLSFDPSL carcinogenesis, induced; apoptosis, inhibited 20841468 14 9 2 coexpression of S163D/S183D with Neu results in faster tumor formation -STAT5B STAT5B DNA-binding; Oncoprotein; Transcription factor P51692 6777 17q21.2 human K705-ac 62484404 GYVKPQIkQVVPEFV phosphorylation transcription, induced 23980167 1 0 0 increases pSTAT5B at Y699 -SMAD4 SMAD4 DNA-binding; Nuclear receptor co-regulator; Transcription, coactivator/corepressor Q13485 4089 18q21.2 human T273-p 36694102 TTWTGSRtAPYTPNL protein degradation; molecular association, regulation; ubiquitination carcinogenesis, inhibited; transcription, inhibited; signaling pathway regulation BTRC(INDUCES) 25373906 1 0 0 -IRF7 IRF7 DNA-binding; Transcription factor Q92985 3665 11p15.5 human S471-p 1276102 GTQREGVsSLDSSSL transcription, inhibited 10893229 3 0 0 -FMNL2 FMNL2 iso3 Cytoskeletal Q96PY5-3 114793 2q23.3 human S1072-p 48891101 RADAVRRsVRRRFDD molecular association, regulation; intracellular localization endocytosis, induced; cell motility, induced ITGA5(INDUCES) 26256210 1 0 0 localization from the plasma membrane to endosomal membrane compartments, promoted cell invasion -CAT Catalase Amino Acid Metabolism - tryptophan; Apoptosis; EC 1.11.1.6; Endoplasmic reticulum; Energy Metabolism - methane; Hydrolase; Mitochondrial; Oxidoreductase P04040 847 11p13 human Y386-p 450445 YRARVANyQRDGPMC Catalase enzymatic activity, induced 12777400 2 0 0 -HSPB1 HSP27 Chaperone; Heat shock protein; Motility/polarity/chemotaxis; SUMO LIGASE; SUMO ligase P15991 hamster S90-p 448403 RALNRQLsSGVSEIR activity, induced; molecular association, regulation apoptosis, altered IKKA(INDUCES); HSP27(DISRUPTS) 10092617; 15033973; 15944157; 16840786 78 104 289 -Pex14 PEX14 Adaptor/scaffold Q642G4 64460 5q36 rat S247-p 1869992403 SWQIPVKsPSPSSPA molecular association, regulation; intracellular localization Catalase(DISRUPTS) 32831175 1 1 0 regulates peroxisomal catalase import -ALDOA ALDOA Carbohydrate Metabolism - fructose and mannose; Carbohydrate Metabolism - glycolysis and gluconeogenesis; Carbohydrate Metabolism - pentose phosphate pathway; EC 4.1.2.13; KINASE; Lyase; Mitochondrial P00883 100009055 rabbit H362-p 451798 ESLFISNhAY_____ Glycolytic enzymatic activity, inhibited 2275541 1 0 0 -SLC29A1 SLC29A1 Membrane protein, integral; Membrane protein, multi-pass; Transporter; Transporter, SLC family Q99808 2030 6p21.1 human S281-p 21326706 QPTNESHsIKAILKN Nucleoside_tran activity, induced 25725289 2 1 0 -RPS6KA3 RSK2 EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, AGC; Protein kinase, Ser/Thr (non-receptor) P51812 6197 Xp22.12 human S227-p 448063 DHEKKAYsFCGTVEY Pkinase activity, induced; enzymatic activity, induced carcinogenesis, induced; cell growth, induced; apoptosis, inhibited 10980595; 23012246; 23708659 14 43 151 upregulation of c-Myc, p21WAF1/CIP1, CCND2 and MCL1 -Fzd3 FZD3 GPCR, Fz/Smo family; Membrane protein, integral; Membrane protein, multi-pass; Receptor, GPCR Q61086 14365 14 D1|14 34.09 cM mouse S637-p 18507002 NEQSRHSsIRDLSNN receptor internalization, inhibited; phosphorylation endocytosis, inhibited 21316586 1 0 0 enhances PCP signaling, regulating c-Jun phosphorylation, and affecting growth cone guidance -TLN1 talin 1 Cytoskeletal; Motility/polarity/chemotaxis Q9Y490 7094 9p13.3 human S446-p 4704923 VGKVEHGsVALPAIM cell motility, altered; cell adhesion, inhibited 27698901 1 4 0 -Brsk2 BRSK2 EC 2.7.11.1; EC 2.7.11.26; KINASE; Kinase, protein; Protein kinase, CAMK; Protein kinase, Ser/Thr (non-receptor) Q69Z98 75770 7|7 F5 mouse T452-p 4734897 PKGTPVHtPKESPAG protein stabilization; enzymatic activity, inhibited; phosphorylation 23790753 1 1 0 inhibits axon branching (activated in BRSK2 18A mutant) -Tal1 TAL1 DNA-binding; Oncoprotein; Transcription factor P22091 21349 4 D1|4 52.73 cM mouse K221-ac 458991 IPTHPPDkKLSKNEI HLH molecular association, regulation cell differentiation, induced; transcription, induced SIN3A(DISRUPTS) DNA(INDUCES) 11118214 1 0 1 -EXO1 EXO1 EC 3.1.-.-; Hydrolase Q9UQ84 9156 1q43 human S746-p 1240803 PGLYKSSsADSLSTT molecular association, regulation; protein conformation chromatin organization, altered; signaling pathway regulation 14-3-3 beta(INDUCES); 14-3-3 sigma(INDUCES); 14-3-3 gamma(INDUCES); 14-3-3 eta(INDUCES) 22222486; 31053472 2 7 3 Ca2+- CAMKK2-AMPK-Exo1 signaling pathway -SMAD3 SMAD3 DNA-binding; Nuclear receptor co-regulator; Transcription factor P84022 4088 15q22.33 human K333-m3 1883845002 WHPATVCkIPPGCNL activity, induced; intracellular localization carcinogenesis, induced; cell motility, induced 35085106 1 1 0 targeting SMAD3 K53/K333 methylation inhibits cancer metastasis; membrane localization; promotes migration and invasion -DAP3 DAP3 Apoptosis; Mitochondrial; Nuclear receptor co-regulator P51398 7818 1q22 human T216-p 2226202 VWNKREStEKGSPLG DAP3 apoptosis, induced 18227431 1 1 0 -APEX1 APE1 DNA repair, damage; DNA-binding; Deoxyribonuclease; EC 4.2.99.18; Endoplasmic reticulum; Hydrolase; Lyase; Nuclear receptor co-regulator; Nucleolus; Transcription, coactivator/corepressor P27695 328 14q11.2 human K25-ub 6423509 RTEPEAKkSKTAAKK protein degradation; enzymatic activity, altered 19219073 1 0 0 -Igf1r IGF1R EC 2.7.10.1; KINASE; Kinase, protein; Membrane protein, integral; Protein kinase, TK; Protein kinase, tyrosine (receptor) Q60751 16001 7 C|7 37.27 cM mouse Y1168-p 448388 DIYETDYyRKGGKGL PK_Tyr_Ser-Thr intracellular localization; enzymatic activity, induced cell cycle regulation; cell growth, induced; cell differentiation, induced 23954591; 35320720; 8940173 16 15 107 -MAPT Tau iso8 ACETYLTRANSFERASE; Acetyltransferase; Cytoskeletal P10636-8 4137 17q21.31 human K353-ac 1877491202 FKDRVQSkIGSLDNI Tubulin-binding molecular association, regulation; protein conformation 34426645 2 1 0 acetylation mimetics are aggregation resistant, inhibit prion-like seeded P301L mutation aggregation, alter conformation of P301L/S320F aggregation; reduced tau microtuble interactions -NR4A1 Nur77 Apoptosis; DNA-binding; Nuclear receptor P22736 3164 12q13.13 human T366-p 1881000304 ASPANLLtSLVRAHL cell adhesion, induced; transcription, induced; signaling pathway regulation 36623453 1 1 0 induces the ?3 integrin/FAK signalling pathway -FEN1 FEN1 DNA repair, damage; DNA-binding; Deoxyribonuclease; EC 3.1.-.-; Nuclear receptor co-regulator; Nucleolus; Ribonuclease P39748 2237 11q12.2 human R192-me 15550800 FGSPVLMrHLTASEA XPG_I molecular association, regulation; methylation; intracellular localization; phosphorylation cell cycle regulation PCNA(INDUCES) 20729856; 32783654 2 1 0 R192 methylation inhibits succinylation -DLG4 PSD-95 Adaptor/scaffold P78352 1742 17p13.1 human S78-p 1875393400 GNSGLGFsIAGGTDN PDZ molecular association, regulation NMDAR2B(DISRUPTS); Stargazin(DISRUPTS) Other(DISRUPTS) 34761188 0 1 0 inhibits binding to AVLX-144 -Cap1 CAP1 Actin-binding; Cytoskeletal P40124 12331 4|4 D2.2 mouse S309-p 2525971 PKPQTSPsPKPATKK molecular association, regulation; intracellular localization cytoskeletal reorganization; cell motility, inhibited Cofilin-1(DISRUPTS); ACTA1(INDUCES) 25315833 5 47 6 -TAX1BP1 TAX1BP1 Apoptosis Q86VP1 8887 7p15.2 human S25-p 1336919201 IFQNVAKsYLPNAHL SKICH molecular association, regulation autophagy, altered NAP1L1(INDUCES) 30459273 1 0 0 -MSX2 MSX2 DNA-binding; Transcription, coactivator/corepressor P35548 4488 5q35.2 human T141-p 25554904 CTLRKHKtNRKPRTP protein stabilization cell differentiation, inhibited; transcription, inhibited 22633971 1 0 0 -Nolc1 NOLC1 Nucleolus; RNA-binding; Transcription, coactivator/corepressor P41777 64896 1q54 rat S628-p 455686 KGEKRASsPFRRVRE activity, induced transcription, altered 12167624 1 37 13 -DAB2IP DAB2IP iso2 GAP; GAP, Ras; Tumor suppressor Q5VWQ8-2 153090 9q33.2 human T531-p 1875342306 DVHTALStPGSGQLP DUF3498 ubiquitination; phosphorylation cell cycle regulation; carcinogenesis, inhibited; chromatin organization, altered; cytoskeletal reorganization PLK1(INDUCES) 34775484 1 0 0 inhibitrs CDC20 ubiquitination, induces PLK1, TTK phosphorylation -ITPR1 IP3R1 Channel, calcium; Channel, ligand-gated; Membrane protein, integral; Membrane protein, multi-pass Q14643 3708 3p26.1 human S1598-p 450681 RNAARRDsVLAASRD molecular association, regulation Calmodulin(DISRUPTS) 17696464 10 51 3 regulates calcium dependent binding -HIF1A HIF1A Autophagy; DNA-binding; Transcription factor Q16665 3091 14q23.2 human K477-sm 3656305 LNQEVALkLEPNPES protein stabilization transcription, induced; transcription, inhibited 15465032; 19680224 2 1 0 -Cdkn1c p57Kip2 iso2 Cell cycle regulation; Inhibitor; Nuclear receptor co-regulator; Tumor suppressor P49919-2 12577 7 F5|7 88.22 cM mouse T143-p 25525402 AEPTPPAtPAPASDL molecular association, regulation cell cycle regulation CDK2(INDUCES) 22569127 1 0 0 promotes cell survival upon osmostress -PPP1R12C PPP1R12C Protein phosphatase, regulatory subunit Q9BZL4 54776 19q13.42 human S452-p 472608 AGLQRSAsSSWLEGT molecular association, regulation 14-3-3 zeta(INDUCES) 22137581 2 28 41 mitotic progression -Rptor Raptor Adaptor/scaffold Q8K4Q0 74370 11|11 E2 mouse T706-p 11315002 ATEGGSLtPVRDSPC molecular association, regulation signaling pathway regulation PRAS40(INDUCES); p70S6K(INDUCES) 24239769 8 9 0 mechanical stress-induced mTOR signaling -RFC1 RFC1 DNA replication P35251 5981 4p14 human T76-p 26334306 SDSESEEtLQVKNAK enzymatic activity, induced 32907938 1 0 1 regulates ATPase activity of hRFC, it decreases in alanine mutation -Per1 PER1 Transcription factor O35973 18626 11|11 B3 mouse S714-p 465536 ALANKAEsVVSVTSQ phosphorylation 16750171 2 0 0 implicated in regulation of phosphorylation of other CK1epsilon sites -Gphn gephyrin Adaptor/scaffold; EC 2.10.1.1; EC 2.7.7.75 Q03555 64845 6q24 rat K756-sm 1876579504 EQYVELHkGEVVDVM MoeA_C molecular association, regulation gephyrin(DISRUPTS) 35307349 1 0 0 -BCAR1 P130Cas Adaptor/scaffold; Motility/polarity/chemotaxis P56945 9564 16q23.1 human Y12-p 4251353 NVLAKALyDNVAESP SH3_1 molecular association, regulation; intracellular localization; phosphorylation; enzymatic activity, induced carcinogenesis, induced; cell motility, induced; cell adhesion, inhibited PTP-PEST(DISRUPTS); FAK(DISRUPTS) 21937722 1 1 2 inhibits tyrosine phosphorylation, induces gelatinase activity -HIC1 HIC1 C2H2-type zinc finger protein; Transcription factor; Tumor suppressor Q14526 3090 17p13.3 human K333-sm 1910102 SLLYRWMkHEPGLGS molecular association, regulation DNA repair, induced; transcription, inhibited RBBP4(INDUCES); MTA1(INDUCES) 17283066; 20547755; 23417673 3 0 0 -PANX1 PANX1 Cell adhesion; Membrane protein, integral; Membrane protein, multi-pass Q96RD7 24145 11q21 human Y10-p 23129120 IAQLATEyVFSDFLL activity, induced carcinogenesis, induced; cell growth, induced 37056395 1 1 2 -NBN NBS1 Cell cycle regulation; DNA repair, damage O60934 4683 8q21.3 human K233-ac 487508 TFIFLNAkQHKKLSS NIBRIN_BRCT_II phosphorylation cell cycle regulation; apoptosis, induced; DNA repair, inhibited 17612497; 28869605 3 1 0 -HMGN1 HMGN1 DNA-binding; Nuclear receptor co-regulator P05114 3150 21q22.2 human S8-p 465531 MPKRKVSsAEGAAKE HMG14_17 intracellular localization 10739259 5 29 6 Phosphorylation facilitates localization to non-nuclear pools. -DROSHA DROSHA EC 3.1.26.3; Nucleolus; RNA processing; RNA-binding; Ribonuclease Q9NRR4 29102 5p13.3 human S355-p 30985044 LEIVNHRsPSREKKR molecular association, regulation DGCR8(DISRUPTS) 25699712 1 12 0 -DCK DCK EC 2.7.1.74; Kinase, other; Nucleotide Metabolism - purine; Nucleotide Metabolism - pyrimidine P27707 1633 4q13.3 human S74-p 456305 EFEELTMsQKNGGNV dNK activity, induced; molecular association, regulation; protein conformation; enzymatic activity, induced cell cycle regulation; DNA repair, induced; autophagy, induced; apoptosis, inhibited; signaling pathway regulation CDK1(INDUCES) 16361699; 17065079; 18258203; 20544527; 20637175; 21351740; 22490700; 22850745; 24462681; 25101980; 27879648; 29393406 16 28 92 IR induced autophagy -MECOM EVI1 C2H2-type zinc finger protein; Methyltransferase, protein lysine, predicted; Oncoprotein; Transcription regulation; Transcription, coactivator/corepressor Q03112 2122 3q26.2 human K752-ac 13362616 TTKRKDEkPLTPVPS molecular association, regulation DNA(INDUCES) 20363750 1 0 0 GATA-2 transcription induced -EZR Ezrin Cytoskeletal; Motility/polarity/chemotaxis P15311 7430 6q25.3 human S66-p 458400 LKLDKKVsAQEVRKE FERM_N molecular association, regulation; intracellular localization; protein conformation; phosphorylation exocytosis, induced; apoptosis, inhibited; cytoskeletal reorganization STX3(INDUCES); DDEFL1(INDUCES) 12840026; 16438931; 25301939; 26010871; 26405038; 28808054 8 1 0 important for cell secretion -METTL3 METTL3 EC 2.1.1.62; METHYLTRANSFERASE; Methyltransferase; RNA processing Q86U44 56339 14q11.2 human S50-p 3204585 SPTFRSDsPVPTAPT protein stabilization; molecular association, regulation; methylation carcinogenesis, induced; cell differentiation, induced USP5(DISRUPTS) 33217317 1 12 0 -WAS WASP Adaptor/scaffold; Motility/polarity/chemotaxis P42768 7454 Xp11.23 human Y102-p 60110900 LLWEQELySQLVYST WH1 protein degradation; molecular association, regulation carcinogenesis, induced; cell growth, induced WIPF1(DISRUPTS) 27694894 1 1 0 -Mapk8ip1 JIP1 Adaptor/scaffold Q9WVI9 19099 2|2 E1 mouse Y409-p 234613502 ESDSATVyDNCASAS molecular association, regulation Src iso1(INDUCES) 28930674 1 0 0 -Nrip1 RIP140 Nuclear receptor co-regulator; Transcription, coactivator/corepressor Q8CBD1 268903 16|16 C3.1 mouse K653-me 6742802 GEEQRPCkQLLSGNP NRIP1_repr_2 molecular association, regulation; methylation transcription, inhibited HDAC3(INDUCES) 19216533 1 1 0 inhibits arginine methylation -CPT2 CPT2 EC 2.3.1.21; Lipid Metabolism - fatty acid; Mitochondrial; Transferase P23786 1376 1p32.3 human K79-ac 1883486800 LNDGQFRkTEQFCKS acetylation 35728063 1 1 0 acetylation causes acylcarnitine accumulation cause mitochondrial damage in platelets and nucleated cells, blocking acylcarnitine generation with AMPK or CPT1 inhibitors, and SIRT3 agonists can induce platelet survival -AATF AATF Nucleolus; RNA-binding; Transcription factor Q9NY61 26574 17q12 human S321-p 460427 AGSEEISsEDDELVE AATF-Che1 acetylation chromatin organization, altered; cell growth, induced; transcription, induced H3(INDUCES) 34266450 1 53 7 induces histone acetylation -SKA3 SKA3 Cell cycle regulation Q8IX90 221150 13q12.11 human T217-p 3205641 MDDFECVtPKLEHFG molecular association, regulation; intracellular localization cell cycle regulation; chromatin organization, altered; cytoskeletal reorganization HEC1(INDUCES) 32491969 1 7 1 -Src Src iso1 EC 2.7.10.2; KINASE; Kinase, protein; Oncoprotein; Protein kinase, TK; Protein kinase, tyrosine (non-receptor) P05480-1 20779 2 H1|2 78.35 cM mouse Y535-p 448235 FTSTEPQyQPGENL_ molecular association, regulation; enzymatic activity, inhibited; enzymatic activity, induced transcription, inhibited; signaling pathway regulation; cell growth, altered Afadin(DISRUPTS); GRB2(INDUCES) 11713208; 17491594; 19147357; 21383697 153 24 968 transcription of miR-99a inhibited.; growth and transformation regulated through Cul5 -TACC3 TACC3 Cell cycle regulation F1NCL7 422899 chicken S569-p 41590808 GTSSFKEsALRKQSL intracellular localization 26134678 1 0 0 localization to the mitotic spindle -NPM/ALK NPM-ALK KINASE; Kinase, protein; Protein kinase, TK; Protein kinase, tyrosine (receptor) AAA58698 human Y156-p 27275109 MTDYNPNyCFAGKTS molecular association, regulation transcription, induced SNTB1(INDUCES); IRS1(INDUCES) 17086210; 17110082; 8633037 3 2 3 -TAB2 TAB2 Adaptor/scaffold Q9NYJ8 23118 6q25.1 human K329-sm 31089526 RKNQIEIkLEPPQRN molecular association, regulation signaling pathway regulation; transcription, inhibited 24096733; 33184450 2 0 0 inhibition of TRAF6/TAB2/TAK1 complex and downstream MAPK and NF-?B pathway -ARAF ARAF EC 2.7.11.1; KINASE; Kinase, protein; Oncoprotein; Protein kinase, Ser/Thr (non-receptor); Protein kinase, TKL P10398 369 Xp11.3 human T455-p 3306307 FGLATVKtRWSGAQP PK_Tyr_Ser-Thr enzymatic activity, induced 18662992 0 1 1 -H2BC3 H2B DNA-binding P33778 3018 6p22.2 human K120-ub 465519 EGTKAVTkYTSSK__ protein stabilization; molecular association, regulation; ubiquitination; intracellular localization; methylation; protein conformation carcinogenesis, induced; carcinogenesis, inhibited; cell growth, inhibited; transcription, induced; transcription, altered; DNA repair, induced; cell growth, induced; chromatin organization, altered; autophagy, inhibited; transcription, inhibited SMARCC1(INDUCES); USP44(DISRUPTS); SMARCA4(INDUCES); NBS1(INDUCES); SMARCB1(INDUCES); DOT1L(INDUCES); BRCA1(INDUCES) 16307923; 16713563; 21362548; 23933260; 26240340; 27132940; 32051583; 32076268; 32458023; 32934196; 35078192; 35172132; 35690146; 35739357; 36419136 35 21 138 Dot1L is recruited OGT to chromatin to enhance histone H2B S112 O-GlcNAc and increases H2B K120 ubiquitination; reduced ubiquitylation level indicated autophagy induction; polyubiquitylation at multiple sites including K120, and monoubiquitylation leads to activation of transcription, K11-linked and K11/K48-branched chains-active APC/C, accumulated at specific genes in mitotic hESCs co-occupied by WDR5 and TBP; p53 target genes including PPM1D, BTG2, PLK2, MDM2, p21Cip1 and PUMA, genes related to ERK/MAPK signalling; UBR7 monoubiquitinatesf histone H2BK120, which a?ects binding of H2BK120ub on Keap1 promoter inducing transcription; enrichment of H2Bk120 is associated with transcriptional elongation and gene expression levels following DNA damage; linc-RA1 stabilized the level of H2B K120 monoubiquitination, inhibiting the interaction of H2BK120 and USP44, which inhibits autophagy; inc-RA1 stabilizes the level of H2Bub1 by inhibiting the interaction between H2Bub1 and USP44, inhibiting autophagy; ubiquitin and nucleosome acidic patch binding by DOT1L are required for cell proliferation in a leukemia model -ETV5 ERM DNA-binding; Transcription factor P41161 2119 3q27.2 human K263-sm 2887208 PPPPQGFkQEYHDPL ETS_PEA3_N transcription, inhibited 15857832; 18243147 2 0 0 -GAREM2 FAM59B Unknown function Q75VX8 150946 2p23.3 human Y551-p 28850310 SPDTYSLyCYPCTWG molecular association, regulation cell differentiation, induced; signaling pathway regulation GRB2(INDUCES) 24003223 1 0 0 -Ripk3 RIPK3 EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, Ser/Thr (non-receptor); Protein kinase, TKL Q9QZL0 56532 14|14 C3 mouse T231-p 27928506 EAELVDKtSLIRETV Pkinase molecular association, regulation; intracellular localization; protein conformation; phosphorylation apoptosis, induced; apoptosis, inhibited MLKL(INDUCES) 23612963; 24902902; 25459880; 31511692; 35648750 13 2 0 -Ppargc1b PGC-1 beta Nuclear receptor co-regulator; Transcription, coactivator/corepressor Q8VHJ7 170826 18|18 E1 mouse K230-ac 7761205 VLPCPRVkACSPTPH intracellular localization transcription, inhibited 19491097 1 1 0 -PKM PKM Carbohydrate Metabolism - glycolysis and gluconeogenesis; Carbohydrate Metabolism - pyruvate; EC 2.7.1.40; KINASE; Kinase, other; Mitochondrial; Nucleotide Metabolism - purine P14618 5315 15q23 human S406-gl 394791403 RRLAPITsDPTEATA molecular association, regulation; intracellular localization; protein conformation; phosphorylation cell growth, induced ERK2(INDUCES); ERK1(INDUCES) 29229835 2 1 0 promotes Warburg effect and cell proliferation, tumor growth, disassociation of the PKM2 tetramer ; nuclear translocation -SLC30A2 SLC30A2 Membrane protein, integral; Membrane protein, multi-pass; Transporter; Transporter, SLC family Q9BRI3 7780 1p36.11 human S296-p 40413916 AVRDLLLsVEGVEAL intracellular localization 25808614 1 0 0 ZnT2 targeted to lysosome, lysosomal-mediated cell death (LCD) -SFTPC SFTPC Lipid-binding P11686 6440 8p21.3 human K6-ub 9381808 __MDVGSkEVLMESP SP_C-Propep protein processing endocytosis, induced 19423771 1 0 0 processing of proSFTPC to mature peptide -PRKCQ PKCT EC 2.7.11.13; KINASE; Kinase, protein; Protein kinase, AGC; Protein kinase, Ser/Thr (non-receptor) Q04759 5588 10p15.1 human T538-p 447907 LGDAKTNtFCGTPDY Pkinase enzymatic activity, induced carcinogenesis, inhibited; autophagy, induced; cell growth, inhibited; signaling pathway regulation; transcription, altered 11772397; 16252004; 21983831; 35403545 17 7 23 -Yap1 YAP1 Oncoprotein; Transcription, coactivator/corepressor P46938 22601 9|9 A1 mouse T48-p 484117 HVRGDSEtDLEALFN intracellular localization carcinogenesis, induced; cell differentiation, induced; transcription, induced 33574090 2 23 0 -Psen1 PSEN1 Cell surface; EC 3.4.23.-; Membrane protein, integral; Membrane protein, multi-pass; Mitochondrial; Protease P49769 19164 12 D1|12 38.84 cM mouse S367-p 454173 AVQELSGsILTSEDP Presenilin molecular association, regulation autophagy, induced ANXA2(INDUCES) 28533411 2 47 3 -CDC34 CDC34 EC 6.3.2.19; Ligase; UBIQUITIN LIGASE; Ubiquitin conjugating system; Ubiquitin ligase P49427 997 19p13.3 human T233-p 448689 DDEDDSGtEES____ intracellular localization 11546811 2 0 0 -Pik3r2 PIK3R2 Kinase, lipid; Motility/polarity/chemotaxis O08908 18709 8 B3.3|8 34.15 cM mouse Y458-p 449572 SREYDQLyEEYTRTS PI3K_P85_iSH2 carcinogenesis, induced; autophagy, induced; cell motility, induced; transcription, induced 22388104; 34706731 10 55 1664 -PSEN2 PSEN2 Cell surface; EC 3.4.23.-; Membrane protein, integral; Membrane protein, multi-pass; Protease P49810 5664 1q42.13 human S330-p 448567 MEEDSYDsFGEPSYP Presenilin; Presenilin protein stabilization apoptosis, inhibited 9990034 2 0 0 Phosphorylation of Presenilin 2 inhibits its cleavage by caspase-3. -ADRA2A ADRA2A GPCR, family 1; Membrane protein, integral; Membrane protein, multi-pass; Receptor, GPCR P08913 150 10q25.2 human S312-p 456350 ALDLEESsSSDHAER 7tm_1 activity, inhibited 7876239 1 2 0 -Lhcgr LHR GPCR, family 1; Membrane protein, integral; Membrane protein, multi-pass; Receptor, GPCR P16235 25477 6q12 rat S665-p 451063 KEFSAYTsNCKNGFP receptor internalization, altered 9660797 1 0 0 S665 is required for agonist-induced uncoupling and internalization. -ORC2 ORC2 DNA replication Q13416 4999 2q33.1 human T116-p 3195386 LASELAKtPQKSVSF molecular association, regulation cell cycle regulation DNA(DISRUPTS) 22334659; 24732362 3 17 15 -Tbxa2r TXA2-R GPCR, family 1; Membrane protein, integral; Membrane protein, multi-pass; Receptor, GPCR P30987 21390 10 C1|10 39.72 cM mouse T226-p 3061801 TLCRVYHtREATQRP 7tm_1 receptor desensitization, altered 12428680 1 0 0 GRK2 mediated but not PKC -BRAF BRAF EC 2.7.11.1; KINASE; Kinase, protein; Oncoprotein; Protein kinase, Ser/Thr (non-receptor); Protein kinase, TKL P15056 673 7q34 human S365-p 450243 GQRDRSSsAPNVHIN molecular association, regulation; enzymatic activity, inhibited transcription, induced; cell growth, altered 14-3-3 beta(INDUCES) 10869359; 11293329; 18451171; 37625591 9 27 30 -Akt1s1 PRAS40 Apoptosis D3ZH75 292887 1q22 rat T247-p 470067 LPRPRLNtSDFQKLK PRAS molecular association, regulation TORC1(DISRUPTS) 20484410 50 69 781 -GTF2F1 GTF2F1 EC 2.7.11.1; KINASE; Kinase, protein; Transcription initiation complex P35269 2962 19p13.3 human S385-p 483594 GGSSRGNsRPGTPSA TFIIF_alpha activity, inhibited transcription, inhibited 10428810 1 52 231 slows down RNA pol II elongation -MAPK14 P38A EC 2.7.11.24; KINASE; Kinase, protein; Protein kinase, CMGC; Protein kinase, Ser/Thr (non-receptor) Q16539 1432 6p21.31 human Y323-p 455799 DEPVADPyDQSFESR phosphorylation; enzymatic activity, induced 15735648 8 1 0 -Bcl2 Bcl-2 Apoptosis; Autophagy; Membrane protein, integral; Oncoprotein P10417 12043 1 E2.1|1 49.76 cM mouse S70-p 448395 RDMAARTsPLRPLVA protein stabilization; molecular association, regulation; phosphorylation cell cycle regulation; autophagy, induced; cell growth, induced; cell differentiation, induced; apoptosis, inhibited BAX(INDUCES); beclin 1(DISRUPTS) 10677502; 11323415; 14660795; 18463240; 32051584; 35183115; 35702893; 37179010; 9115213 49 1 0 -Axin1 axin 1 Adaptor/scaffold; Tumor suppressor O70239 79257 10q12 rat T480-p 451091 HVQRVMRtPGCQSPG Axin_b-cat_bind cytoskeletal reorganization 22933777 5 6 0 Phosphorylation regulates responsive to Sema3A induced growth cone collapse. -PTPN11 SHP-2 iso1 EC 3.1.3.48; Motility/polarity/chemotaxis; PHOSPHATASE; Protein phosphatase, tyrosine (non-receptor) Q06124-1 5781 12q24.13 human T73-p 40407604 YGGEKFAtLAELVQY SH2 molecular association, regulation; enzymatic activity, inhibited; phosphorylation GAB1(DISRUPTS); GAB2(DISRUPTS); PRKD1(DISRUPTS) 25802336 1 0 0 enhances phosphorylation of PKD1 -FURIN FURIN Cell surface; EC 3.4.21.75; Membrane protein, integral; Protease; Vesicle P09958 5045 15q26.1 human S775-p 469743 QEECPSDsEEDEGRG intracellular localization 8846780 2 9 0 retrieval to the trans-Golgi network -ATM ATM DNA repair, damage; EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, Ser/Thr (non-receptor); Protein kinase, atypical; Tumor suppressor Q13315 472 11q22.3 human Y370-p 38535268 SLEISQSyTTTQRES enzymatic activity, induced 25601159 1 1 0 facilitates its activation upon IR treatment -STK11 LKB1 Autophagy; EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, CAMK; Protein kinase, Ser/Thr (non-receptor); Tumor suppressor Q15831 6794 19p13.3 human T402-p 11454702 TEAAQLStKSRAEGR enzymatic activity, induced 12805220 1 0 0 STRAD increases LKB1 activation -Dzip1 DZIP1 C2H2-type zinc finger protein Q8BMD2 66573 14|14 E4 mouse S706-p 21241901 FGKSAVKsDTDWTEG transcription, induced; signaling pathway regulation 21878643 1 0 0 involved in Gli1 nad Gli3 turnover pathway -SLC2A1 GLUT1 Membrane protein, integral; Membrane protein, multi-pass; Transporter; Transporter, SLC family P11166 6513 1p34.2 human S490-p 477830 FHPLGADsQV_____ activity, induced; molecular association, regulation; intracellular localization carcinogenesis, induced; cell motility, induced; translation, induced; signaling pathway regulation GIPC1(INDUCES) 23776597; 30799198 2 16 49 Increased glucose and DHA transport, increased cell surface expression of GLUT1; induce PKM2 activation and glycolysis -Chuk IKKA EC 2.7.11.10; KINASE; Kinase, protein; Protein kinase, Other; Protein kinase, Ser/Thr (non-receptor) Q60680 12675 19 C3|19 36.71 cM mouse S180-p 447779 DQGSLCTsFVGTLQY Pkinase enzymatic activity, induced cell differentiation, inhibited; apoptosis, altered; apoptosis, induced; transcription, altered; cell growth, altered 15935065; 18497757; 35449211; 35637461 44 0 0 -ICAM3 ICAM3 Cell adhesion; Immunoglobulin superfamily; Membrane protein, integral P32942 3385 19p13.2 human S516-p 451212 VFREHQRsGSYHVRE intracellular localization 11784723 1 0 1 -TEK TIE2 EC 2.7.10.1; KINASE; Kinase, protein; Membrane protein, integral; Protein kinase, TK; Protein kinase, tyrosine (receptor) Q02763 7010 9p21.2 human Y1108-p 448372 TYVNTTLyEKFTYAG enzymatic activity, induced 20973951 4 0 1 -LILRB2 LILRB2 Membrane protein, integral; Receptor, misc. Q8N423 10288 19q13.42 human Y591-p 464930 PPAEPSIyATLAIH_ molecular association, regulation CSK(INDUCES); SHP-1(INDUCES) 11907092; 15474475 2 0 1 Mutation of Y533 prevented binding in vivo. -AQP4 AQP4 iso4 Channel, misc.; Membrane protein, integral; Membrane protein, multi-pass; Transporter; Transporter, aquaporin family A0A5F9ZHR4 361 18q11.2 human S331-p 1877492100 XLEDRTEsRQDSLEL intracellular localization 35625560 1 0 0 -ZBTB16 PLZF C2H2-type zinc finger protein; DNA-binding; Oncoprotein; Transcription, coactivator/corepressor Q05516 7704 11q23.2 human K242-sm 2303904 HPGVAEVkTEMMQVD protein stabilization; molecular association, regulation; ubiquitination; intracellular localization cell cycle regulation; cell growth, inhibited; apoptosis, inhibited; transcription, inhibited DNA(INDUCES) 14527952; 17498654; 18348865; 18396468 4 0 0 nuclear localization, inhibits ubiquitination; nuclear localization -PDP1 PDP1 EC 3.1.3.43; Mitochondrial; Motility/polarity/chemotaxis; PHOSPHATASE; Protein phosphatase, Ser/Thr (non-receptor) Q9P0J1 54704 8q22.1 human Y381-p 15422118 DQLNDNEyTKFIPPN PP2C molecular association, regulation SIRT3(DISRUPTS); ACAT1(INDUCES) 24486017 2 1 0 -SLC6A12 SLC6A12 Membrane protein, integral; Membrane protein, multi-pass; Transporter; Transporter, SLC family P27799 404013 dog T612-p 454881 LIVGEKEtHL_____ molecular association, regulation; phosphorylation LIN7C(DISRUPTS) 15591048 1 0 0 -MARK2 MARK2 EC 2.7.11.1; EC 2.7.11.26; KINASE; Kinase, protein; Protein kinase, CAMK; Protein kinase, Ser/Thr (non-receptor) Q7KZI7 2011 11q13.1 human S619-p 455400 PYGVTPAsPSGHSQG cell cycle regulation; carcinogenesis, induced; apoptosis, inhibited 35780183 1 34 102 -THEM4 CTMP EC 3.1.2.2; Mitochondrial Q5T1C6 117145 1q21.3 human S37-p 9721501 RPELRSFsSEEVILK intracellular localization 19604401 1 1 0 -MOK MOK EC 2.7.11.22; KINASE; Kinase, protein; Protein kinase, CMGC; Protein kinase, Ser/Thr (non-receptor) Q9UQ07 5891 14q32.31 human T159-p 450005 VYSKQPYtEYISTRW Pkinase activity, induced 10421840 1 1 0 While the authors did not prove that these sites were phosphorylated, mutation of both T159 and Y161, located in the activation loop, abolished the enzymatic activity of the kinase. -Nfatc4 NFAT3 DNA-binding; Transcription factor Q8K120 73181 14|14 C3 mouse S170-p 448860 GGAFFSPsPGSSSLS intracellular localization; activity, inhibited transcription, altered 18347059; 18691762; 27307045 7 0 1 -TBK1 TBK1 EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, Other; Protein kinase, Ser/Thr (non-receptor) Q9UHD2 29110 12q14.2 human K692-ac 1881543100 EMTLGMKkLKEEMEG molecular association, regulation TBK1(DISRUPTS) 32772249 1 1 0 dimerization- effect of K692A,D mutants -Traf6 TRAF6 EC 6.3.2.-; Ligase; UBIQUITIN LIGASE; Ubiquitin conjugating system; Ubiquitin ligase P70196 22034 2|2 E2 mouse T471-p 40240800 LLAFQRPtIPRNPKG ubiquitination; protein conformation transcription, inhibited 25642822 1 0 0 prevent its oligomerization and autoubiquitination, inhibits LPS-stimulated transcription of Tnf and Il6 -NME1 NME1 EC 2.7.4.6; KINASE; Kinase, nucleoside diphosphate; Kinase, other; Nucleotide Metabolism - purine; Nucleotide Metabolism - pyrimidine; Protein kinase, histidine; Tumor suppressor P15531 4830 17q21.33 human S44-p 450096 GLKFMQAsEDLLKEH NDK cell growth, altered 12859952 4 1 1 inhibits colony formation in soft agar -Hist1h2ail1 H3 DNA-binding Q6LED0 291159 17p11 rat S28-p 455677 ATKAARKsAPATGGV Histone transcription, induced 22025646 50 18 0 at c-Jun and PAI gene promoters -Amph amphiphysin Vesicle Q7TQF7 218038 13 A2|13 6.89 cM mouse T260-p 3147510 GPLRIAKtPSPPEEP endocytosis, altered 18761055 1 8 1 -NUMA1 NuMA-1 Cell cycle regulation; Motility/polarity/chemotaxis Q14980 4926 11q13.4 human S2047-p 4748253 KQADRRQsMAFSILN intracellular localization cell growth, induced; apoptosis, inhibited 23097092 3 26 2 cell proliferation increased -Mpl MPL Membrane protein, integral; Receptor, cytokine Q08351 17480 4 D2.1|4 54.61 cM mouse S568-p 3091405 ILPKSSEsTPLPLCP activity, induced; phosphorylation cell growth, altered 10918061 1 0 0 tyrosine phosphorylation of JAK2 -Ctnnd1 CTNND1 Actin-binding; Adaptor/scaffold; Cell adhesion; G protein regulator, misc.; Motility/polarity/chemotaxis P30999 12388 2 D|2 49.45 cM mouse S268-p 450453 PQVRVGGsSVDLHRF molecular association, regulation cell adhesion, inhibited 26175155; 26845024 12 73 56 310A and 268A mutants showed clumping, overall phosphorylation regulates activity; decreased homophilic binding affinity of E-cadherin -RCAN1 RCAN1 iso2 Inhibitor P53805-2 1827 21q22.12 human S93-p 25687504 AQTLHIGsSHLAPPN Calcipressin protein stabilization transcription, inhibited 25753203 3 2 0 enhances the inhibition of calcineurin activity -KCNA3 Kv1.3 Channel, potassium; Membrane protein, integral; Membrane protein, multi-pass P22001 3738 1p13.3 human S511-p 4703603 SCQHLSSsAEELRKA cell growth, induced 26655221 1 1 1 -CASQ2 calsequestrin 2 Calcium-binding P12637 483134 dog S401-p 451475 GNNSDEEsNDDSDDD intracellular localization 21431367 2 1 0 regulates intracellular trafficking of calsequestrin 2 -Gja4 GJA4 Cell adhesion; Membrane protein, integral; Membrane protein, multi-pass P28235 14612 4 D2.2|4 61.47 cM mouse S275-p 1867850300 PMGEGPSsPPCPTYN protein conformation apoptosis, induced; apoptosis, inhibited 30736283 1 0 0 intramolecular interaction between the mid- and the end-tail of GJA4; at low cells density; at high cells density -HDAC9 HDAC9 DEACETYLASE; Deacetylase; EC 3.5.1.98; Transcription, coactivator/corepressor Q9UKV0 9734 7p21.1 human S253-p 13204427 KDGNVVTsFKKRMFE intracellular localization 20188095 1 0 0 -NR3C2 MCR DNA-binding; Nuclear receptor P08235 4306 4q31.23 human S287-p 4767239 SVKSPVSsPNNVTLR protein degradation; ubiquitination transcription, inhibited 22798426 1 5 0 -GAB2 GAB2 Adaptor/scaffold Q9UQC2 9846 11q14.1 human S159-p 448382 LLRERKSsAPSHSSQ molecular association, regulation cell growth, altered HER2(DISRUPTS); SHC1(DISRUPTS) 11782427 3 1 0 Introduction of the S159A mutation markedly enhanced HRG-stimulated tyrosine phosphorylation of Gab2. A global amplification of HRG-induced tyrosine phosphorylation was observed in cells expressing S159A Gab2. -DGCR8 DGCR8 Nucleolus; RNA processing; RNA-binding Q8WYQ5 54487 22q11.21 human S280-p 14572439 HPSDGETsVQPMMTK protein stabilization 24239349 0 2 1 -NEDD4 NEDD4 EC 6.3.2.-; EC 6.3.2.19; Ligase; Nuclear receptor co-regulator; UBIQUITIN LIGASE; Ubiquitin conjugating system; Ubiquitin ligase P46934 4734 15q21.3 human K1279-ub 1877089302 EQWGTPEkLPRAHTC HECT protein stabilization; molecular association, regulation autophagy, induced USP13(INDUCES); PIK3C3(INDUCES) 32101753 1 0 0 autoregulated K29 linked ubiquitination required for interaction with USP13 and VPS34, deubiquitination and stabilization of VPS3, deubiquitination and stabilization of VPS34, promoting the formation of autophagosomes -ARHGAP18 ARHGAP18 GAP; GAP, Rac/Rho Q8N392 93663 6q22.33 human T158-p 4760950 RVETVSQtLRKKNKQ cytoskeletal reorganization 25456499 1 6 2 spine development -EGFR EGFR EC 2.7.10.1; KINASE; Kinase, protein; Membrane protein, integral; Oncoprotein; Protein kinase, TK; Protein kinase, tyrosine (receptor) P00533 1956 7p11.2 human Y1125-p 449795 APSRDPHyQDPHSTA molecular association, regulation GRB2(INDUCES) 16729043 5 1 40 -WWTR1 TAZ Oncoprotein; Transcription, coactivator/corepressor Q9GZV5 25937 3q25.1 human S90-p 4777166 QHVRSHSsPASLQLG protein degradation; activity, inhibited carcinogenesis, inhibited; cell growth, inhibited; cell motility, inhibited; transcription, inhibited 26183396; 26375055 2 6 14 -UVRAG UVRAG Autophagy Q9P2Y5 7405 11q13.5 human S550-p 4761506 KITSLSSsLDTSLDF enzymatic activity, induced 26139536 2 22 0 alters lysosomal morphology and lysosomal tubulation -EIF2AK2 PKR EC 2.7.10.2; EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, Other; Protein kinase, Ser/Thr (non-receptor); Protein kinase, tyrosine (non-receptor); Translation P19525 5610 2p22.2 human S456-p 3181637 KGTLRYMsPEQISSQ Pkinase carcinogenesis, induced; cell motility, induced; cell growth, induced; apoptosis, inhibited 34799660 1 5 0 -PTPN6 SHP-1 EC 3.1.3.48; Motility/polarity/chemotaxis; PHOSPHATASE; Protein phosphatase, tyrosine (non-receptor) P29350 5777 12p13.31 human Y536-p 448506 QKGQESEyGNITYPP molecular association, regulation; enzymatic activity, induced cell motility, induced; cell growth, induced; transcription, induced; cell adhesion, inhibited; transcription, inhibited; signaling pathway regulation GRB2(INDUCES) 12468540; 14551136; 14699166; 17675340; 18377662; 21900501; 28692056; 34010642 20 24 637 -CAPZA1 CAPZA1 Actin-binding; Motility/polarity/chemotaxis P52907 829 1p13.2 human S106-p 27445584 DHLRKEAsDPQPEEA F-actin_cap_A cell motility, induced; cell adhesion, induced; cytoskeletal reorganization 32771000 1 5 0 -Gnaq G-alpha(q) G protein; G protein, heterotrimeric; G protein, heterotrimeric alpha G(q) P21279 14682 19 A|19 11.01 cM mouse Y356-p 449722 LQLNLKEyNLV____ activity, induced mAChR m1(NOT_REPORTED) 9188537 2 0 2 -TCF4 TCF4 DNA-binding; Transcription factor P15884 6925 18q21.2 human S56-p 451216 NVEDRSSsGSWGNGG molecular association, regulation transcription, induced CTNNG(DISRUPTS) 11711551 1 0 0 -IL1RL1 IL1RL1 Membrane protein, integral; Receptor, cytokine Q01638 9173 2q12.1 human K511-ub 1883430200 MKVQGTIkWREDHIA protein stabilization; phosphorylation transcription, induced; signaling pathway regulation 35238669 1 0 0 Il-33?induced phosphorylation, induction of downstream inflammatory genes -PTEN PTEN Carbohydrate Metabolism - inositol phosphate; EC 3.1.3.16; EC 3.1.3.48; EC 3.1.3.67; Motility/polarity/chemotaxis; Nuclear receptor co-regulator; PHOSPHATASE; Phosphatase, lipid; Tumor suppressor P60484 5728 10q23.31 human K80-ub 27205464 ERHYDTAkFNCRVAQ ubiquitination 30631154 3 5 0 PTEN dephosphorylates master regulators of EMT in vivo; K27-linked polyubiquitination alters PTEN substrate binding; converted PTEN from a phosphoinositide/protein tyrosine phosphatase to a protein serine/threonine phosphatase -Bcl2l11 BIM Apoptosis O54918 12125 2|2 F1 mouse S105-p 471329 DRSPAPMsCDKSTQT protein degradation apoptosis, inhibited 17105963 1 0 0 -Kcnq2 Kv7.2 Channel, potassium; Membrane protein, integral; Membrane protein, multi-pass O88943 170848 3q43 rat S541-p 11082901 SKRKFKEsLRPYDVM KCNQ_channel activity, induced; molecular association, regulation Calmodulin(DISRUPTS) 12754513; 22643219 3 0 0 reduces the affinity with PIP2; Mutants showed reduced currents induced by acetylcholine. -BRD4 BRD4 KINASE; Kinase, protein; Protein kinase, Ser/Thr (non-receptor); Protein kinase, atypical O60885 23476 19p13.12 human K99-me 1881502504 LNLPDYYkIIKTPMD molecular association, regulation transcription, induced; transcription, inhibited; translation, inhibited E2F1(INDUCES) 34039605; 36300937 2 1 0 HPV transcriptional activation; inhibits the expression of genes involved in mRNA translation, translation?related target genes -Nkx2-1 NKX2-1 Cell development/differentiation; DNA-binding; Transcription factor P50220 21869 12 C1|12 24.42 cM mouse S23-p 21478902 ILSPLEEsYKKVGME molecular association, regulation carcinogenesis, induced; cell growth, induced; transcription, induced DNA(INDUCES) 36194647 2 1 0 -Grb10 GRB10 Adaptor/scaffold Q60760 14783 11 A1|11 7.15 cM mouse S455-p 455333 NAPMRSVsENSLVAM BPS molecular association, regulation 14-3-3 eta(INDUCES) 15722337 2 8 0 -NF1 NF1 iso2 GAP; GAP, Ras; Motility/polarity/chemotaxis; Nucleolus; Tumor suppressor P21359-2 4763 17q11.2 human S2576-p 456014 HPHLRKVsVSESNVL molecular association, regulation; activity, inhibited 14-3-3 beta(INDUCES) 14741381 1 18 10 -ITGB7 ITGB7 Cell adhesion; Membrane protein, integral; Motility/polarity/chemotaxis; Receptor, misc. P26010 3695 12q13.13 human T783-p 450186 PLYKSAItTTINPRF Integrin_b_cyt molecular association, regulation FLNA(DISRUPTS) 16455489 2 0 0 based on glutamate mutant of threonine site -EPHA4 EphA4 EC 2.7.10.1; KINASE; Kinase, protein; Membrane protein, integral; Protein kinase, TK; Protein kinase, tyrosine (receptor) P54764 2043 2q36.1 human Y596-p 450856 LNQGVRTyVDPFTYE EphA2_TM enzymatic activity, induced 21439481 5 14 75 -TBC1D4 AS160 GAP; GAP, Rab O60343 9882 13q22.2 human T642-p 455921 QFRRRAHtFSHPPSS molecular association, regulation endocytosis, induced; signaling pathway regulation 14-3-3 beta(INDUCES); 14-3-3 theta(INDUCES); 14-3-3 epsilon(INDUCES) 16880201; 17617058; 20410134; 26465605 45 21 134 albumin endocytosis; multiple sites (6P) mutant -TRIM65 TRIM65 Ubiquitin conjugating system Q6PJ69 201292 17q25.1 human S181-p 1871608302 CILASWVsGKFSSLL carcinogenesis, inhibited; signaling pathway regulation 31332286 1 1 0 dephosphorylated form (6A mutant) contributes to TRIM65 function in tumor progression -Prkcb PKCB EC 2.7.11.13; KINASE; Kinase, protein; Motility/polarity/chemotaxis; Protein kinase, AGC; Protein kinase, Ser/Thr (non-receptor) P68403 25023 1q36 rat T635-p 1869073012 SNFDKEFtRQPVELT Pkinase_C intracellular localization; enzymatic activity, induced transcription, altered 8327493 3 0 0 increases expression of c-Fos and c-Jun -Lpxn leupaxin Adaptor/scaffold; Cytoskeletal; Motility/polarity/chemotaxis Q99N69 107321 19|19 A mouse Y72-p 449706 NIQEPNVySEVQEPK activity, induced 17640867 2 2 48 important for laupaxin-mediated repression of BCR-induced IL-2 production -MAP3K2 MEKK2 EC 2.7.11.25; KINASE; Kinase, protein; Protein kinase, STE; Protein kinase, Ser/Thr (non-receptor) Q9Y2U5 10746 2q14.3 human T522-p 1904500 GTGMKSVtGTPYWMS Pkinase phosphorylation; enzymatic activity, induced transcription, altered 16362041 1 1 0 Mutation of S520A inhibits activation and is the key residue. Double mutation of T522A,T524A reduces activation effect. T522A seems to have the least effect of the three single mutations. The triple STT to AAA mutation is akin to kinase dead. Activation leads to Erk5 and JNKK2 phosphorylation/activation. -Mlf2 MLF2 Cell adhesion Q99KX1 30853 6|6 F2 mouse S28-p 13261776 AIHRQHMsRMLSGGF Mlf1IP activity, induced carcinogenesis, induced; cell growth, induced 31831854 1 2 0 -PTPN12 PTP-PEST EC 3.1.3.48; Motility/polarity/chemotaxis; PHOSPHATASE; Protein phosphatase, tyrosine (non-receptor) Q05209 5782 7q11.23 human S571-p 1983755 KTVSLTPsPTTQVET molecular association, regulation; phosphorylation carcinogenesis, induced; cell motility, induced; cell adhesion, inhibited FAK(INDUCES); PIN1(INDUCES) 21876001 1 13 3 induces dephosphorylation of FAK -Map3k11 MLK3 EC 2.7.11.25; KINASE; Kinase, protein; Protein kinase, Ser/Thr (non-receptor); Protein kinase, TKL Q80XI6 26403 19 A|19 4.34 cM mouse T278-p 448263 LAREWHKtTQMSAAG PK_Tyr_Ser-Thr enzymatic activity, induced 34324442 8 0 0 -AFF1 AF-4 Oncoprotein; Transcription factor P51825 4299 4q21.3-q22.1 human T220-p 3191677 PIHSNQQtLPRTQGS AF-4 protein degradation; molecular association, regulation; intracellular localization transcription, induced 14-3-3 theta(INDUCES); CDK9(INDUCES) 21574958 1 3 1 nuclear import-export -SATB2 SATB2 DNA-binding Q9UPW6 23314 2q33.1 human K233-sm 2894437 YKKYKKIkVERVERE CUTL molecular association, regulation; intracellular localization transcription, inhibited DNA(DISRUPTS) 14701874 1 0 0 -AGO2 AGO2 EC 3.1.26.n2; RNA processing; RNA-binding Q9UKV8 27161 8q24.3 human K402-sm 34823402 REFGIMVkDEMTDVT ArgoL2 protein degradation 25036361 1 0 0 -FGR FGR EC 2.7.10.2; KINASE; Kinase, protein; Mitochondrial; Oncoprotein; Protein kinase, TK; Protein kinase, tyrosine (non-receptor) P09769 2268 1p35.3 human Y412-p 448120 RLIKDDEyNPCQGSK PK_Tyr_Ser-Thr carcinogenesis, induced; DNA repair, induced 29989005 4 8 197 -STK4 MST1 Autophagy; EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, STE; Protein kinase, Ser/Thr (non-receptor) Q13043 6789 20q13.12 human T367-p 7445972 TLPSQLGtMVINAED molecular association, regulation MOB1A(INDUCES); MST1(DISRUPTS) 28373297; 28373298 2 3 0 fluorescence polarization -NDRG1 NDRG1 Cell development/differentiation; Vesicle Q92597 10397 8q24.22 human S330-p 452879 LMRSRTAsGSSVTSL protein degradation; molecular association, regulation; intracellular localization; phosphorylation carcinogenesis, induced; carcinogenesis, inhibited; carcinogenesis, altered; cell motility, induced; transcription, induced AR(DISRUPTS) 20416281; 21719465; 33398037 10 74 485 -MAPT Tau iso3 ACETYLTRANSFERASE; Acetyltransferase; Cytoskeletal P10636-3 4137 17q21.31 human S108-p 447928 SGYSSPGsPGTPGSR molecular association, regulation cytoskeletal reorganization 10747907 175 57 116 regulates association with membrane -NR5A1 STF-1 Nuclear receptor; Transcription, coactivator/corepressor Q13285 2516 9q33.3 human K119-sm 2798301 QIRANGFkLETGPPM molecular association, regulation; intracellular localization transcription, inhibited PITX1(DISRUPTS); RAD54L2(INDUCES) DNA(INDUCES) 15192092; 19692572; 19995909 7 0 0 -RET Ret EC 2.7.10.1; KINASE; Kinase, protein; Membrane protein, integral; Oncoprotein; Protein kinase, TK; Protein kinase, tyrosine (receptor) P07949 5979 10q11.21 human Y806-p 450700 PLLLIVEyAKYGSLR PK_Tyr_Ser-Thr enzymatic activity, induced cell growth, altered 14711813 1 0 0 -CD79B Ig-beta Membrane protein, integral; Receptor, misc. P40259 974 17q23.3 human Y196-p 459286 GMEEDHTyEGLDIDQ phosphorylation signaling pathway regulation 37467575 2 1 5 inhibits DOCK8 phosphorylation, regulates BCR signaling -ACBD4 ACBD4 Lipid-binding Q8NC06 79777 17q21.31 human S183-p 1876128604 DSEVFCDsLEQLEPE molecular association, regulation VAPB(DISRUPTS) 35019937 1 0 0 -ADD1 ADD1 Cytoskeletal; Motility/polarity/chemotaxis P35611 118 4p16.3 human S726-p 449829 KKKFRTPsFLKKSKK molecular association, regulation; intracellular localization cell cycle regulation; carcinogenesis, induced; endocytosis, induced; cell motility, induced; cytoskeletal reorganization TPX2(INDUCES) 15910744; 17341583; 21736685; 23349050; 29925526; 31548578; 9679146 24 57 158 -Mfn1 MFN1 EC 3.6.5.-; Hydrolase; Membrane protein, integral; Membrane protein, multi-pass; Mitochondrial Q8R4Z9 192647 2q24 rat S86-p 1498941800 AFFGRTSsGKSSVIN Dynamin_N enzymatic activity, inhibited apoptosis, induced 30659190 1 1 0 -MAF1 MAF1 Transcription regulation Q9H063 84232 8q24.3 human T64-p 3211923 EALSPPQtSGLSPSR Maf1 transcription, induced 20233713 1 4 1 -ANXA1 ANXA1 Calcium-binding; Lipid-binding P04083 301 9q21.13 human T24-p 452052 EEQEYVQtVKSSKGG molecular association, regulation ACTB(INDUCES) 27634935 2 0 0 -Mark1 MARK1 EC 2.7.11.1; EC 2.7.11.26; KINASE; Kinase, protein; Protein kinase, CAMK; Protein kinase, Ser/Thr (non-receptor) O08678 117016 13q26 rat T215-p 456037 TVGNKLDtFCGSPPY Pkinase enzymatic activity, induced 9108484 4 45 33 -Nono NONO Nuclear receptor co-regulator; Nucleolus; RNA splicing; RNA-binding Q99K48 53610 X|X D mouse T15-p 18013091 NLEKQNHtPRKHHQH molecular association, regulation RNA(DISRUPTS) 21819346 1 3 15 except G-rich RNA -ERRFI1 MIG-6 Inhibitor; Tumor suppressor Q9UJM3 54206 1p36.23 human S251-p 3215403 RRLRRSHsGPAGSFN activity, induced; phosphorylation signaling pathway regulation; cell growth, altered 22505024 3 41 39 EGF-signaling, EGFR autophosphorylation enhanced -HDAC1 HDAC1 DEACETYLASE; Deacetylase; EC 3.5.1.98; Hydrolase; Nuclear receptor co-regulator Q13547 3065 1p35.2-p35.1 human K220-ac 4219802 DIGAGKGkYYAVNYP Hist_deacetyl enzymatic activity, inhibited transcription, inhibited 16762839 1 2 5 -CHMP4C CHMP4C Vesicle Q96CF2 92421 8q21.13 human S215-p 1221009 RRSRAASsQRAEEED cell cycle regulation 22724069 2 1 22 mutations of site increase cytokinesis failure -Tpt1 TPT1 Calcium-binding; Microtubule-binding P63028 22070 14 D3|14 40.29 cM mouse S46-p 476067 TEGAIDDsLIGGNAS TCTP phosphorylation cell cycle regulation; apoptosis, altered; cytoskeletal reorganization 12167714 8 11 9 -GRK1 GRK1 EC 2.7.11.14; KINASE; Kinase, protein; Protein kinase, AGC; Protein kinase, Ser/Thr (non-receptor) Q15835 6011 13q34 human T492-p 2530400 QDVGAFStVKGVAFD molecular association, regulation Rhodopsin(INDUCES) 34262173 3 1 0 -MAP2K4 MKK4 EC 2.7.12.2; KINASE; Kinase, protein; Protein kinase, STE; Protein kinase, dual-specificity (non-receptor) P45985 6416 17p12 human Y269-p 1881548606 RDAGCRPyMAPERID enzymatic activity, inhibited carcinogenesis, inhibited; apoptosis, induced; transcription, inhibited 37020040 1 1 0 -EIF2AK2 PKR EC 2.7.10.2; EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, Other; Protein kinase, Ser/Thr (non-receptor); Protein kinase, tyrosine (non-receptor); Translation P19525 5610 2p22.2 human S97-p 1872824902 TNSSEGLsMGNYIGL molecular association, regulation; enzymatic activity, inhibited; protein conformation; phosphorylation apoptosis, inhibited PKR(INDUCES) RNA(INDUCES) 33911136 1 1 0 inhibits phosphorylation at other sites and of elF2 -Nanog NANOG Cell development/differentiation; DNA-binding; Transcription factor Q80Z64 71950 6|6 F1 mouse S130-p 1870790707 LQQMQELsSILNLSY Homeodomain molecular association, regulation; protein conformation DNA(DISRUPTS) 33107035 1 1 0 decreases self-renewal function of NANOG -Mpz myelin P0 Adaptor/scaffold; Membrane protein, integral P06907 24564 13q24 rat S233-p 458933 SRSTKAAsEKKSKGL Myelin-PO_C cell adhesion, altered 17502419 4 1 0 -Birc5 Survivin Apoptosis O70201 11799 11|11 E2 mouse T34-p 447705 FLEDCACtPERMAEA BIR protein stabilization; ubiquitination carcinogenesis, induced; apoptosis, inhibited; cell growth, altered 10949038; 18816410; 36450751 19 6 7 -AURKB AurB EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, Other; Protein kinase, Ser/Thr (non-receptor) Q96GD4 9212 17p13.1 human K85-sm 25087009 EIGRPLGkGKFGNVY Pkinase phosphorylation; enzymatic activity, induced 21554500 1 0 0 induces phosphorylation at T232 -PICK1 PICK1 Adaptor/scaffold; Cell development/differentiation; Ligand, receptor tyrosine kinase Q9NRD5 9463 22q13.1 human S411-p 50642304 GPLDKGGsWCDS___ molecular association, regulation GluR2(INDUCES) 26472923 1 2 0 S415 was essential for binding to GluA2 -EIF2AK2 PKR EC 2.7.10.2; EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, Other; Protein kinase, Ser/Thr (non-receptor); Protein kinase, tyrosine (non-receptor); Translation P19525 5610 2p22.2 human T88-p 3753308 AVSPLLLtTTNSSEG enzymatic activity, induced 11152499 1 0 0 -Map3k1 MEKK1 EC 2.7.11.25; KINASE; Kinase, protein; Ligase; Protein kinase, STE; Protein kinase, Ser/Thr (non-receptor); UBIQUITIN LIGASE; Ubiquitin conjugating system; Ubiquitin ligase P53349 26401 13 D2.2|13 63.36 cM mouse S71-p 3053616 RQLRKVRsVELDQLP enzymatic activity, induced 25260751 2 2 0 -PAPOLA PAP-alpha EC 2.7.7.19; RNA processing; RNA splicing; Transferase P51003 10914 14q32.2 human K662-sm 2586342 PHKEESPkKTKTEED protein stabilization; intracellular localization; enzymatic activity, inhibited 18281463 1 0 0 -Dppa4 DPPA4 Cell development/differentiation Q8CCG4 73693 16|16 B5 mouse K141-sm 1877126903 RLKTAHKkMKTEPGE transcription, inhibited 32937131 1 1 0 -Cdk7 CDK7 Cell cycle regulation; EC 2.7.11.22; EC 2.7.11.23; KINASE; Kinase, protein; Nuclear receptor co-regulator; Protein kinase, CMGC; Protein kinase, Ser/Thr (non-receptor) Q03147 12572 13 D1|13 53.23 cM mouse S164-p 450041 GLAKSFGsPNRAYTH Pkinase enzymatic activity, induced 7553872 4 52 21 -NOX5 NOX5 iso4 EC 1.6.3.-; Membrane protein, integral; Membrane protein, multi-pass; Oxidoreductase Q96PH1-4 79400 15q23 human S490-p 20612401 GRGSKRLsRSVTMRK FAD_binding_8 activity, induced; enzymatic activity, induced 24505490; 24992705 3 0 0 -CKAP2 CKAP2 Cell cycle regulation Q8WWK9 26586 13q14.3 human T623-p 460436 FKELKFLtPVRRSRR CKAP2_C protein degradation cell cycle regulation 19369249; 19641375 2 5 3 -GPSM2 GPSM2 G protein regulator, misc. P81274 29899 1p13.3 human S408-p 4766076 PKLGRRHsMENMELM molecular association, regulation; intracellular localization cell cycle regulation G-alpha i2(DISRUPTS) 20933426 2 21 9 stimulates binding to 14-3-3 -USP28 USP28 DEUBIQUITINASE; EC 3.4.19.12; Protease; Ubiquitin-specific protease Q96RU2 57646 11q23.2 human S714-p 467253 ESSTNSSsQDYSTSQ molecular association, regulation; ubiquitination; enzymatic activity, induced carcinogenesis, induced; DNA repair, induced; apoptosis, altered KLHL2(DISRUPTS) 16901786; 31938050; 34611298 4 4 0 induces substrate deubiquitination -ADD2 ADD2 Cytoskeletal; Motility/polarity/chemotaxis P35612 119 2p13.3 human S613-p 3147399 AKEAETKsPLVSPSK phosphorylation cell growth, induced; cytoskeletal reorganization 21606488 1 18 4 -Irf7 IRF7 DNA-binding; Transcription factor P70434 54123 7|7 F5 mouse K406-sm 3278901 EKTLILVkLEPWVCK IRF-3 transcription, inhibited 18635538 1 0 0 -Zc3h10 ZC3H10 DNA-binding Q8R205 103284 10|10 D3 mouse S126-p 36133857 VAAGLGLsPADLPNG molecular association, regulation transcription, induced DNA(INDUCES) 31775033 1 4 0 induces binding to UCP1 promoters -Scn8a SCN8A Channel, sodium; Membrane protein, integral; Membrane protein, multi-pass Q9WTU3 20273 15 56.39 cM|15 F1 mouse S553-p 456209 SLLSIPGsPFLSRHN Na_trans_cytopl molecular association, regulation; activity, inhibited NEDD4L(INDUCES) 20530479 2 0 1 -SSB SSB Transcription initiation complex P05455 6741 2q31.1 human T389-p 477729 VKRAREEtDKEEPAS carcinogenesis, induced; cell motility, induced; cell growth, induced; translation, induced 25520193; 33477794 2 5 153 Regulates cancer cell plasticity; CCND1 IRES-mediated translation (not Cap-dependent translation), inhibits RNA chaperon activity, regulates helix destabilization activity of La -NEDD1 NEDD1 Cell cycle regulation Q8NHV4 121441 12q23.1 human S568-p 25533011 AGVASSLsEKIADSI molecular association, regulation cytoskeletal reorganization TUBG1(INDUCES) 22595525 2 2 0 Promote NEDD1 activity; regulates spindle assembly in mitosis -RET Ret EC 2.7.10.1; KINASE; Kinase, protein; Membrane protein, integral; Oncoprotein; Protein kinase, TK; Protein kinase, tyrosine (receptor) P07949 5979 10q11.21 human Y900-p 450702 FGLSRDVyEEDSYVK PK_Tyr_Ser-Thr enzymatic activity, induced 14711813; 16928683; 28009299 2 4 23 -IL6ST gp130 Membrane protein, integral; Receptor, cytokine P40189 3572 5q11.2 human Y767-p 450053 STVVHSGyRHQVPSV cell cycle regulation; transcription, altered 10623831 2 1 5 -Grin2c NMDAR2C Channel, calcium; Channel, ligand-gated; Membrane protein, integral; Membrane protein, multi-pass Q00961 24411 10q32.1 rat S1231-p 463822 SCTWRRVsSLESEV_ activity, induced 16606616 1 1 0 regulates kinetics of ion channel -Tsc2 TSC2 iso2 Cell cycle regulation; GAP; GAP, misc.; Nuclear receptor co-regulator; Tumor suppressor P49816-2 24855 10q12 rat T1228-p 450211 PTLPRSNtVASFSSL phosphorylation 14651849 1 3 0 regulates p70S6K phosphorylation -SDC1 syndecan-1 Extracellular matrix; Membrane protein, integral; Motility/polarity/chemotaxis P18827 6382 2p24.1 human Y286-p 458494 KKKDEGSySLEEPKQ Syndecan endocytosis, induced 29109268 2 9 29 -MVP MVP RNA-binding Q14764 9961 16p11.2 human T52-p 28102700 FAPMRMVtVPPRHYC Vault_2 molecular association, regulation; activity, inhibited DNA repair, induced 14-3-3 epsilon(INDUCES) 23590642 1 0 0 14-3-3e negatively regulating the BLM resistance activity of MVP and induce DDR -Gabrg2 GABRG2 iso2 Channel, chloride; Channel, ligand-gated; Membrane protein, integral; Membrane protein, multi-pass; Transporter; Transporter, ion channel P22723-2 14406 11 A5|11 24.8 cM mouse Y405-p 455818 ERDEEYGyECLDGKD Neur_chan_memb receptor inactivation, induced; activity, induced; receptor internalization, inhibited neural plasticity 17442679; 23904608; 24068823 7 0 0 potentiated GABA currents; neurogenesis, reduces depressive like behaviors; knockout leads to increease in GABA mediated tonic current, in females only -VAV3 VAV3 Actin-binding; Adaptor/scaffold; GEF; GEF, Rac/Rho; Motility/polarity/chemotaxis; Nuclear receptor co-regulator Q9UKW4 10451 1p13.3 human Y173-p 455605 EDEGGEVyEDLMKAE activity, induced 11917103; 32561640 6 0 0 VAV3 signaling activity -H4C1 H4 DNA-binding P62805 8359 6p22.2 human R3-me 4145501 _____SGrGKGGKGL acetylation cell cycle regulation; chromatin organization, altered; transcription, induced; transcription, inhibited 11387442; 15345777; 19741270 6 0 0 regulates epigenetic regulation of chromation in a cell-cycle dependent manner -CYLD CYLD DEUBIQUITINASE; EC 3.4.19.12; Protease; Tumor suppressor; Ubiquitin conjugating system; Ubiquitin-specific protease Q9NQC7 1540 16q12.1 human S422-p 4745563 RFHSLPFsLTKMPNT CYLD_phos_site ubiquitination 15870263 1 14 4 induces ubiquitination of TRAF2 -XRCC6 Ku70 DNA repair, damage; DNA-binding; EC 3.6.4.-; EC 4.2.99.-; Helicase; Nuclear receptor co-regulator; RNA-binding P12956 2547 22q13.2 human S33-p 50247606 ASGDYKYsGRDSLIF molecular association, regulation; intracellular localization cell cycle regulation; DNA repair, induced; chromatin organization, altered; DNA repair, altered; apoptosis, inhibited UBE2M(DISRUPTS); UBE2A(INDUCES); RIF1(INDUCES); N4BP1(INDUCES); POLR2F(INDUCES); UBE2G2(INDUCES); TIF1G(INDUCES) DNA(DISRUPTS) 26337656; 34718776 2 1 0 -PELI1 PELI1 Adaptor/scaffold; EC 6.3.2.-; EC 6.3.2.19; Ligase; UBIQUITIN LIGASE; Ubiquitin conjugating system; Ubiquitin ligase Q96FA3 57162 2p14 human S39-p 1870773105 GDRGRRKsRFALFKR Pellino protein degradation; molecular association, regulation; ubiquitination RIPK1(DISRUPTS); TICAM1(DISRUPTS); ubiquitin(DISRUPTS) 33052227 1 0 0 -SEC16A SEC16A EC 3.1.3.36; Phosphatase (non-protein) O15027 9919 9q34.3 human S846-p 55578720 LAQPINFsVSLSNSH intracellular localization autophagy, induced 27203176 1 1 0 assembly of COPII components at ERESs and traf?cking of associated secretory cargos -CDKN1B p27Kip1 Cell cycle regulation; Inhibitor; Oncoprotein; Protein kinase, regulatory subunit P46527 1027 12p13.1 human S10-p 447874 NVRVSNGsPSLERMD protein degradation; molecular association, regulation; protein stabilization; intracellular localization; phosphorylation cell cycle regulation; carcinogenesis, induced; cell motility, induced; cell adhesion, induced; transcription, altered; cell growth, induced; apoptosis, inhibited; cytoskeletal reorganization CTNNB1(DISRUPTS); Exportin-1(INDUCES) 10831586; 11726503; 11889117; 12093740; 12119282; 12482975; 12529437; 12700233; 15579463; 16160006; 18272788; 19672859; 20851109; 21715331; 23230143; 25205104; 26223520; 26307683; 26528715; 27175940; 27197201; 33316141 47 36 1 migration and invasion, cytoplasmic localization; S-phase entry in E7 expressing cells -Pttg1 Securin Cell cycle regulation; Oncoprotein Q9CQJ7 30939 11|11 B1.1 mouse S162-p 452603 LLHLGPPsPLKTPFL Securin activity, induced; intracellular localization transcription, altered 10906323 2 50 2 -Prkar2b PKAR2B Mitochondrial; Protein kinase, regulatory subunit P12369 24679 6q16 rat T69-p 10941783 GAAAGGGtPSKGVNF protein conformation; phosphorylation neural plasticity 35835216 1 12 1 -Ctnnb1 CTNNB1 Actin-binding; Cell adhesion; Motility/polarity/chemotaxis; Nuclear receptor co-regulator; Oncoprotein; Transcription factor Q02248 12387 9 F4|9 72.19 cM mouse S29-p 3075000 VSHWQQQsYLDSGIH protein degradation; ubiquitination 9233789 3 2 4 -AFAP1 AFAP Adaptor/scaffold Q8N556 60312 4p16.1 human S277-p 2853100 AELEKKLsSERPSSD cytoskeletal reorganization 18577577 1 13 1 -Trp53 p53 iso2 Activator; DNA-binding; Motility/polarity/chemotaxis; Nuclear receptor co-regulator; Transcription factor; Tumor suppressor Q80ZA1 22059 11 B3|11 42.83 cM mouse K117-ac 474514 FLQSGTAkSVMCTYS P53 transcription, induced 27705786 44 8 0 -HSF1 HSF1 DNA-binding; Transcription factor Q00613 3297 8q24.3 human K80-ac 6741100 LNMYGFRkVVHIEQG HSF_DNA-bind protein degradation; molecular association, regulation; ubiquitination; intracellular localization apoptosis, induced; transcription, inhibited DNA(DISRUPTS) 19229036; 26503960; 28547133 5 2 0 -Glrb GLRB Channel, ligand-gated; Membrane protein, integral; Membrane protein, multi-pass; Transporter; Transporter, ion channel P48168 14658 3 E3|3 35.71 cM mouse S425-p 2048205 NDFSIVGsLPRDFEL Neur_chan_memb receptor internalization, induced; molecular association, regulation; intracellular localization neural plasticity; endocytosis, induced PACSIN1(INDUCES); gephyrin(DISRUPTS) 21829170; 35879097 2 3 0 -PPP1R16B PPP1R16B Motility/polarity/chemotaxis; Protein phosphatase, regulatory subunit Q96T49 26051 20q11.23 human S331-p 62459400 SQLRHKSsLSRRTSS molecular association, regulation; intracellular localization; activity, inhibited ERM(DISRUPTS) 27939168 1 0 0 membrane localization -MECOM EVI1 C2H2-type zinc finger protein; Methyltransferase, protein lysine, predicted; Oncoprotein; Transcription regulation; Transcription, coactivator/corepressor Q03112 2122 3q26.2 human S384-p 28704101 ICEVCHKsYTQFSNL zf-C2H2 molecular association, regulation transcription, inhibited DNA(DISRUPTS) 23776681 1 1 0 -EEA1 EEA1 C2H2-type zinc finger protein; Vesicle Q15075 8411 12q22 human T1392-p 456871 CSAKNALtPSSKKPV FYVE activity, induced; intracellular localization 16138080 1 0 0 Phosphorylation required for efficient binding to endosome membranes. Aspartate mutation can restore EEA1 fusion activity in the absence of p38a. -MYH10 MYH10 Motility/polarity/chemotaxis; Motor P35580 4628 17p13.1 human S1938-p 4730824 GGPISFSsSRSGRRQ cytoskeletal reorganization 25869664 1 10 3 poorly defined actomyosin bundles distributed throughout the cell -PDE4D PDE4D iso6 EC 3.1.4.53; Nucleotide Metabolism - purine; Phosphodiesterase Q08499-6 5144 5q11.2-q12.1 human S651-p 451090 YQSTIPQsPSPAPDD enzymatic activity, altered 31209056 7 3 0 -H2AX H2AX DNA repair, damage; DNA-binding; Helicase P16104 3014 11q23.3 human Y39-p 462307 RLLRKGHyAERVGAG Histone carcinogenesis, induced; carcinogenesis, inhibited; autophagy, induced; cell growth, induced; transcription, induced; transcription, altered 27813335; 30185813; 31736361 3 2 2 -VDR VDR DNA-binding; Nuclear receptor; Transcription factor P11473 7421 12q13.11 human S51-p 451285 CKGFFRRsMKRKALF zf-C4 transcription, induced 1656468 2 0 0 Mutation of S51 inhibited transcriptional activation by the vitamin D hormone, suggesting that phosphorylation of S51 could play a role in vitamin D dependent transcriptional activation. -CYLD CYLD DEUBIQUITINASE; EC 3.4.19.12; Protease; Tumor suppressor; Ubiquitin conjugating system; Ubiquitin-specific protease Q9NQC7 1540 16q12.1 human Y15-p 4157933 QEKVTSPyWEERIFY protein degradation; molecular association, regulation; ubiquitination Cbl-b(INDUCES) 28572092 1 3 3 degradation of EGFR -SGK1 SGK1 EC 2.7.11.1; KINASE; Kinase, protein; Motility/polarity/chemotaxis; Protein kinase, AGC; Protein kinase, Ser/Thr (non-receptor) O00141 6446 6q23.2 human T369-p 448432 DLINKKItPPFNPNV enzymatic activity, induced 11096081 2 0 0 -TGFBR1 TGFBR1 EC 2.7.11.30; KINASE; Kinase, protein; Membrane protein, integral; Protein kinase, Ser/Thr (receptor); Protein kinase, TKL; Receptor, misc. P36897 7046 9q22.33 human Y182-p 7791190 TTLKDLIyDMTTSGS TGF_beta_GS molecular association, regulation Src(INDUCES) 36378749 2 1 2 src autophosphorylation induced -Map3k7 TAK1 EC 2.7.11.25; KINASE; Kinase, protein; Protein kinase, Ser/Thr (non-receptor); Protein kinase, TKL P0C8E4 313121 5q21 rat T184-p 454876 GTACDIQtHMTNNKG PK_Tyr_Ser-Thr enzymatic activity, induced cell cycle regulation; autophagy, induced; cell motility, induced; cell growth, induced 35078016 20 0 0 -NCOA2 SRC-2 Motility/polarity/chemotaxis; Nuclear receptor co-regulator; Transcription, coactivator/corepressor Q15596 10499 8q13.3 human S493-p 468245 LSPRHRMsPGVAGSP NCOA_u2 transcription, induced 22158970 2 38 0 -TLR8 TLR8 Membrane protein, integral; Receptor, misc. Q9NR97 51311 Xp22.2 human Y880-p 953801 LSTSQTFyDAYISYD TIR activity, induced signaling pathway regulation 17868034 1 0 0 activates NF-kB activity -Ssh2 SSH2 Actin-binding; EC 3.1.3.16; EC 3.1.3.48; PHOSPHATASE; Protein phosphatase, dual-specificity Q5SW75 237860 11|11 B5 mouse S32-p 22775200 SGEEECRsQPRSISE enzymatic activity, inhibited cytoskeletal reorganization; cell motility, inhibited 22172670 1 0 0 -Cd28 CD28 Cell surface; Membrane protein, integral P31041 12487 1 C2|1 30.52 cM mouse Y189-p 450282 NRLLQSDyMNMTPRR molecular association, regulation; phosphorylation cell growth, induced; transcription, induced PIK3CB(INDUCES); PIK3CD(INDUCES); PIK3R1(INDUCES); PIK3CA(INDUCES) 21188463; 24048955; 9973466 10 7 317 induces phosphorylation of ERK and AKT and transcription of IL-2 -PARP1 PARP1 DNA repair, damage; EC 2.4.2.30; Nuclear envelope; Nuclear receptor co-regulator; Nucleolus; Transferase P09874 142 1q42.12 human S782-p 3180399 YSLLRGGsDDSSKDP PARP_reg intracellular localization; enzymatic activity, inhibited; enzymatic activity, induced 21922195; 25069723 2 34 1 Non-apoptotic cell death induced -IQCB1 IQCB1 Cell development/differentiation Q15051 9657 3q13.33|3q21.1 human K31-ub 95155301 NVPVILLkLKEIINI intracellular localization cell cycle regulation; cytoskeletal reorganization 28498859 1 2 0 regulation of cilia formation -Mybpc3 MYBPC3 Myosin-binding P56741 295929 3q24 rat S307-p 471081 SSLLKKSsFRRDSKL cytoskeletal reorganization 35288601 28 6 0 -Pdlim2 PDLIM2 Cell adhesion; UBIQUITIN LIGASE; Ubiquitin ligase Q8R1G6 213019 14|14 D2 mouse S137-p 4763817 PRPCSPFsTPPPTSP ubiquitination; enzymatic activity, induced 20889505 1 14 28 PDLIM2 is STAT1 ubiquitin E3 ligase -UBA2 SAE2 EC 6.3.2.-; EC 6.3.2.19; Ligase; Motility/polarity/chemotaxis; SUMO LIGASE; SUMO conjugating system; SUMO ligase; UBIQUITIN LIGASE; Ubiquitin conjugating system; Ubiquitin ligase Q9UBT2 10054 19q13.11 human K623-sm 10304919 EKENLSAkRSRIEQK UBA2_C intracellular localization 23095757 2 2 0 nuclear localization -Ddit3 DDIT3 Autophagy; DNA-binding; Oncoprotein; Transcription factor P35639 13198 10|10 D3 mouse S107-p 40509923 RTRKRKQsGQCPARP bZIP_2 intracellular localization 32673756 1 2 0 -DNMT1 DNMT1 Amino Acid Metabolism - cysteine and methionine; Cell development/differentiation; EC 2.1.1.37; METHYLTRANSFERASE; Methyltransferase; Methyltransferase, DNA; Transcription regulation P26358 1786 19p13.2 human K259-ac 25171012 PTPKQKLkEEPDREA cell cycle regulation 21947282 1 1 0 -HMGA1 HMGA1 iso2 DNA-binding P17096-2 3159 6p21.31 human K54-ac 458952 RGRPKGSkNKGAAKT AT_hook apoptosis, induced 11389094 4 3 0 -Cebpa C/EBP-alpha DNA-binding; Transcription factor P05554 24252 1q21 rat K302-ac 56394105 AVRKSRDkAKQRNVE bZIP_2 molecular association, regulation autophagy, induced beclin 1(INDUCES) 34217716 2 0 0 -DNMT1 DNMT1 Amino Acid Metabolism - cysteine and methionine; Cell development/differentiation; EC 2.1.1.37; METHYLTRANSFERASE; Methyltransferase; Methyltransferase, DNA; Transcription regulation P26358 1786 19p13.2 human K1609-sm 12726305 ESASAKIkEEEAAKD enzymatic activity, induced DNA(INDUCES) 19450230 1 1 0 -CAPZB CAPZB iso1 Actin-binding; Motility/polarity/chemotaxis P47756-1 832 1p36.13 human S192-p 23090287 GTMNLGGsLTRQMEK F_actin_cap_B cell motility, induced; cell adhesion, induced; cytoskeletal reorganization 32771000 1 1 1 -Rfc1 RFC1 DNA replication D3ZFT1 89809 14p11 rat S361-p 3136107 GSPTKREsVSPEDSE transcription, induced 10625661 1 11 0 -CAPN2 CAPN2 EC 3.4.22.53; Motility/polarity/chemotaxis; Protease P17655 824 1q41 human Y625-p 3413522 RSGTMNSyEMRKALE enzymatic activity, induced carcinogenesis, induced; cell growth, inhibited 35697802 1 0 1 -Ptk2 FAK EC 2.7.10.2; KINASE; Kinase, protein; Protein kinase, TK; Protein kinase, tyrosine (non-receptor) P34152 14083 15 D3|15 33.94 cM mouse Y925-p 447966 DRSNDKVyENVTGLV Focal_AT molecular association, regulation; phosphorylation cell motility, induced; cell adhesion, induced; cytoskeletal reorganization; transcription, altered; cell growth, altered GRB2(INDUCES) 16682956; 16818654; 33711252; 35325397; 7997267; 8816475; 9148935; 9566877 104 17 427 induces cofilin phosphorylation -Myocd myocardin Cell development/differentiation; Transcription factor Q8VIM5 214384 11|11 B3 mouse S632-p 3627509 TFLSPQCsPQHSPLG transcription, inhibited 16141410 1 0 0 -ADAR ADAR EC 3.5.4.37; Hydrolase; Nucleolus; RNA processing; RNA-binding P55265 103 1q21.3 human K574-ub 59149208 TILLEEAkAKDSGKS protein degradation 27729454 1 1 0 regulation of IFN-signaling induced anti-viral activity -ILF3 NFAT90 DNA-binding; Nucleolus; RNA-binding; Transcription factor Q12906 3609 19p13.2 human S382-p 456735 EEDGEEKsPSKKKKK intracellular localization cell cycle regulation; carcinogenesis, induced; cell growth, induced; RNA stability, induced 32123579 1 55 13 -COIL coilin Oxidoreductase P38432 8161 17q22 human S489-p 483597 LELTSSYsPDVSDYK protein degradation; molecular association, regulation; enzymatic activity, inhibited; intracellular localization; activity, inhibited cell cycle regulation; cell growth, inhibited; RNA stability, induced RNA(INDUCES) 21991343; 23616925 2 16 0 nucleolar accumulation; not observed during transient expression; Cajal body formation, phosphomutant cell lines show a significant reduction in CB formation compared to wild-type after endogenous coilin knockdown; inhibits coilin RNAse activity -LIME1 LIME1 Adaptor/scaffold; Membrane protein, integral Q9H400 54923 20q13.33 human Y200-p 454607 AAQVDVLySRVCKPK LIME1 molecular association, regulation CSK(INDUCES) 14610046 1 8 85 -SYTL1 SYTL1 Q8IYJ3 84958 1p36.11 human S241-p 456480 RMLSSSSsVSSLNSS intracellular localization RAB27A(NOT_REPORTED) 15998322 1 0 0 -CHCHD2 CHCHD2 Mitochondrial Q9Y6H1 51142 7p11.2 human Y99-p 62463400 PARPDITyQEPQGTQ transcription, inhibited 33257573 3 1 0 induces mitochondrial respiration -RXRA RXRA DNA-binding; Motility/polarity/chemotaxis; Nuclear receptor P19793 6256 9q34.2 human K108-sm 12004418 VSSSEDIkPPLGLNG Nuc_recep-AF1 transcription, inhibited 16912044; 23690070 2 1 0 -KCNMA1 KCNMA1 Channel, potassium; Endoplasmic reticulum; Membrane protein, integral; Membrane protein, multi-pass Q28204 282573 cow S1151-p 14364501 NRQNRPKsRESRDKQ activity, inhibited 20385812 1 0 0 -RUBCNL RUBCNL Q9H714 80183 13q14.13 human K483-ac 1875445903 LMMWDFKkYYVSNFS zf-RING_9 molecular association, regulation autophagy, induced VPS39(INDUCES); VPS41(INDUCES); STX17(INDUCES) 30704899 1 1 0 required for autophagosome maturation and cellular lipid metabolism -Dab1 DAB1 Adaptor/scaffold Q8CJH2 266729 5q33-q34 rat S400-p 479417 TNDSARSsPQSDKPR molecular association, regulation CD2AP(DISRUPTS); SH3KBP1(DISRUPTS) 18076569 3 0 0 -XKR5 XKR5 Membrane protein, integral; Membrane protein, multi-pass Q6UX68 389610 8p23.1 human Y487-p 1172732402 DPLETSSyVSFASDQ phosphorylation carcinogenesis, inhibited; cell growth, inhibited; signaling pathway regulation 29910466 1 1 0 inhibits phosphorylation of ERK, AKT and p38 -BCL2L11 BIM Apoptosis O43521 10018 2q13 human S93-p 8080215 SSLLSRSsSGYFSFD protein degradation; molecular association, regulation; ubiquitination BTRC(INDUCES) 23912711 1 0 0 -SPRY2 SPRY2 Adaptor/scaffold; Inhibitor; Motility/polarity/chemotaxis O43597 10253 13q31.1 human T75-p 4145505 KPAPRPStQHKHERL activity, inhibited 18678649 2 0 0 -Tom1l1 Srcasm Adaptor/scaffold Q923U0 71943 11 D|11 55.47 cM mouse Y392-p 451208 NLASSHTyDNFHSNS molecular association, regulation cell growth, altered GRB2(INDUCES) 11711534; 17046829 3 0 1 mutation of this site promotes hyperproliferative phenotype -TAX1BP1 TAX1BP1 iso2 Apoptosis Q86VP1-2 8887 7p15.2 human S624-p 468908 RPPVRVPsWGLEDNV molecular association, regulation; ubiquitination signaling pathway regulation TRAF2(INDUCES); TRAF6(INDUCES) 21765415 1 21 106 regulates NF-kB signaling; ; regulates interaction with A20 and Itch via TRAF2 and TRAF6 -Aicda AID EC 3.5.4.38; Hydrolase Q9WVE0 11628 6|6 F1 mouse T140-p 6835300 GVQIGIMtFKDYFYC APOBEC2 molecular association, regulation; intracellular localization DNA repair, inhibited RPA1(INDUCES) 21113164 3 0 0 interaction of RPA with Igh -UBA2 SAE2 EC 6.3.2.-; EC 6.3.2.19; Ligase; Motility/polarity/chemotaxis; SUMO LIGASE; SUMO conjugating system; SUMO ligase; UBIQUITIN LIGASE; Ubiquitin conjugating system; Ubiquitin ligase Q9UBT2 10054 19q13.11 human K613-sm 27851104 EERSRKRkLDEKENL UBA2_C intracellular localization 23095757 1 1 0 nuclear localization -FBXW7 FBXW7 Motility/polarity/chemotaxis; Nucleolus; UBIQUITIN LIGASE; Ubiquitin conjugating system; Ubiquitin ligase Q969H0 55294 4q31.3 human T205-p 25585000 GLVPCSAtPTTFGDL protein degradation; molecular association, regulation; ubiquitination carcinogenesis, induced; cell growth, induced; apoptosis, inhibited; transcription, induced PIN1(INDUCES) 22608923; 25753158; 31152129; 33271455 5 1 0 -PPP1CC PPP1CC EC 3.1.3.16; Motility/polarity/chemotaxis; Nucleolus; PHOSPHATASE; Protein phosphatase, Ser/Thr (non-receptor) P36873 5501 12q24.11 human T318-p 11379600 TPPRGMItKQAKK__ enzymatic activity, inhibited 10880350 1 1 0 in vitro -TAB1 TAB1 Activator; Motility/polarity/chemotaxis Q15750 10454 22q13.1 human S438-p 456224 TPTLTNQsPTLTLQS molecular association, regulation; enzymatic activity, induced; phosphorylation carcinogenesis, induced; autophagy, induced; signaling pathway regulation GFAT(INDUCES) 19393267; 24403530; 35945223 8 1 0 TCR-signaling by DUSP14; induces p38 activity; inhibits TAK1 T187 phosphorylation -NFE2L2 NRF2 DNA-binding; Transcription factor Q16236 4780 2q31.2 human K596-ac 23940022 GNVFLVPkSKKPDVK molecular association, regulation; intracellular localization transcription, induced DNA(INDUCES) 21196497 1 0 0 -RHOT1 RHOT1 EC 3.6.5.-; G protein; G protein, monomeric; G protein, monomeric, Rho; Hydrolase; Membrane protein, integral; Mitochondrial Q8IXI2 55288 17q11.2 human S156-p 21587701 AKNLKNIsELFYYAQ Ras protein degradation autophagy, induced 22078885; 35455950 4 1 0 induces mitophagy; arrest of mitochondrial motility -Zfp24 ZNF24 C2H2-type zinc finger protein; DNA-binding; Transcription factor Q91VN1 59057 18|18 A2 mouse T330-p 480061 INHQRIHtGEKPYEC molecular association, regulation cell differentiation, inhibited; transcription, inhibited DNA(DISRUPTS) 29786073; 29791837 2 7 49 regulates oligodendrocyte differentiation and CNS myelination; mediates the expression of Sox10 and Myrf; oligodendrocyte differentiation and myelination -GSTA4 GSTA4 EC 2.5.1.18; Other Amino Acids Metabolism - glutathione; Transferase; Xenobiotic Metabolism - drug metabolism - cytochrome P450; Xenobiotic Metabolism - metabolism by cytochrome P450 O15217 2941 6p12.2 human T193-p 455667 VKLSNIPtIKRFLEP GST_C_3 molecular association, regulation; intracellular localization HSP70(INDUCES) 12646569 1 0 0 -PML PML Nucleolus; Oncoprotein; SUMO LIGASE; SUMO conjugating system; SUMO ligase; Transcription factor; Tumor suppressor; Ubiquitin conjugating system P29590 5371 15q24.1 human T409-p 469197 ASPEAAStPRDPIDV DUF3583 carcinogenesis, altered 20832753 1 9 28 -AR AR DNA-binding; Nuclear receptor; Transcription factor P10275 367 Xq12 human Y535-p 470068 MDSYSGPyGDMRLET intracellular localization cell cycle regulation; cell growth, induced; transcription, induced; transcription, altered 17045208; 28055971 4 1 0 -RPS6KA5 MSK1 EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, AGC; Protein kinase, Ser/Thr (non-receptor) O75582 9252 14q32.11 human T581-p 448217 PDNQPLKtPCFTLHY Pkinase intracellular localization; enzymatic activity, induced cell growth, induced; transcription, induced; cytoskeletal reorganization 15568999; 15728587; 17429437; 19940164; 25958199 16 1 0 transcriptional activation of Fra-1 and c-Jun -Gucy1a1 GUCY1A1 EC 4.6.1.2; Guanylyl cyclase; Lyase; Nucleotide Metabolism - purine; Receptor, misc. P19686 497757 2q34 rat S108-p 450955 IKENRNSsEKEDLER enzymatic activity, induced 14630997 1 0 0 -Cftr CFTR Channel, chloride; EC 3.6.3.49; Hydrolase; Membrane protein, integral; Membrane protein, multi-pass; Transporter; Transporter, ABC family P26361 12638 6 A2|6 8.1 cM mouse S660-p 449979 FTEERRSsILTETLR CFTR_R protein conformation 19927121 9 8 0 in vitro -INSR INSR EC 2.7.10.1; KINASE; Kinase, protein; Membrane protein, integral; Protein kinase, TK; Protein kinase, tyrosine (receptor) P06213 3643 19p13.2 human Y1361-p 447684 SYEEHIPyTHMNGGK protein conformation; enzymatic activity, induced cell cycle regulation; cell growth, altered 10852715; 10940390; 1618780; 1654097 15 7 14 antibodies against Y1355 and Y1361 peptides stimulated cell proliferation. ; decreases ERK activation -IFITM2 IFITM2 Membrane protein, integral; Membrane protein, multi-pass Q01629 10581 11p15.5 human Y19-p 15230944 NSGQPPNyEMLKEEQ intracellular localization 26354436 1 2 3 Wild-type was localized in cytoplasm and perinuclear, while Y19A,Y20A was localized at plasma membrane. -Ndel1 NDEL1 Microtubule-binding; Protease Q9ERR1 83431 11|11 B3 mouse T219-p 468252 ASLSLPAtPVGKGTE NUDE_C activity, induced; intracellular localization cell motility, altered; cytoskeletal reorganization 18331715; 25698733 6 15 3 impaired transport of DISC1and PAFAH1B1 to neurite tips, inhibited microtuble elongation; Cdc42 activation -CBL CBL Adaptor/scaffold; EC 6.3.2.-; EC 6.3.2.19; Ligase; Motility/polarity/chemotaxis; Oncoprotein; UBIQUITIN LIGASE; Ubiquitin conjugating system; Ubiquitin ligase P22681 867 11q23.3 human S642-p 4704608 PRLGSTFsLDTSMSM molecular association, regulation 14-3-3 eta(INDUCES) 11024037 1 4 7 -GAK GAK Cell cycle regulation; EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, Other; Protein kinase, Ser/Thr (non-receptor) O14976 2580 4p16.3 human Y1149-p 23108884 CTQPRPNyASNFSVI intracellular localization; phosphorylation cell cycle regulation; cell growth, induced 28135906 1 0 3 regulation of MCM2 and timing of MCM3 S112 phosphorylation -ERBB2 HER2 EC 2.7.10.1; KINASE; Kinase, protein; Membrane protein, integral; Oncoprotein; Protein kinase, TK; Protein kinase, tyrosine (receptor) P04626 2064 17q12 human Y1248-p 447614 PTAENPEyLGLDVPV activity, induced; protein stabilization; molecular association, regulation; intracellular localization; phosphorylation cell cycle regulation; carcinogenesis, induced; cell motility, induced; transcription, induced; signaling pathway regulation; cell growth, induced; cell motility, altered; apoptosis, inhibited; cytoskeletal reorganization CPNE3(INDUCES); RACK1(INDUCES); SHC1(INDUCES) 11238891; 12354693; 12748185; 16729043; 18332126; 20010870; 21499301; 27345410; 31978707; 32029900; 37331014 60 15 200 -ESRRA ERR1 DNA-binding; Nuclear receptor; Transcription regulation P11474 2101 11q13.1 human K129-ac 15211513 EITKRRRkACQACRF zf-C4 molecular association, regulation transcription, inhibited DNA(DISRUPTS) 20484414 1 0 0 -SNAI2 Snail2 Apoptosis; C2H2-type zinc finger protein; Motility/polarity/chemotaxis; Transcription factor O43623 6591 8q11.21 human K211-ac 1876931101 IRTHTGEkPFSCPHC protein stabilization cell motility, induced 32737855 1 1 0 promotes breast cancer cell EMT and migration -CPSF3 CPSF3 EC 3.1.27.-; RNA processing; RNA splicing; RNA-binding; Ribonuclease Q9UKF6 51692 2p25.1 human K465-sm 2586338 FRGEKLAkVMGFLAD RNA splicing, altered; cell growth, induced 17923699 1 0 0 regulation of mRNA 3'-end processing- cleavage and polyadenylation -MEF2C MEF2C DNA-binding; Transcription factor Q06413 4208 5q14.3 human K391-sm 7533202 STQSLNIkSEPVSPP transcription, inhibited 16478538 1 0 0 -Ulk1 ULK1 Autophagy; EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, Other; Protein kinase, Ser/Thr (non-receptor) O70405 22241 5|5 F mouse T574-p 17741300 PKLPKPPtDPLGATF autophagy, altered 21205641 0 4 6 -SRC Src EC 2.7.10.2; KINASE; Kinase, protein; Oncoprotein; Protein kinase, TK; Protein kinase, tyrosine (non-receptor) P12931 6714 20q11.23 human S493-p 1871762502 CPPECPEsLHDLMCQ PK_Tyr_Ser-Thr enzymatic activity, inhibited; phosphorylation 33388549 1 0 0 inhibits phosphorylation at Y419 -UHRF1 UHRF1 DNA-binding; EC 6.3.2.-; EC 6.3.2.19; Ligase; Transcription factor; UBIQUITIN LIGASE; Ubiquitin conjugating system; Ubiquitin ligase Q96T88 29128 19p13.3 human S661-p 469962 GGPSRAGsPRRTSKK intracellular localization 22072796 3 12 0 essential for pre-gastrula development in zebrafish -Vcl Vinculin Cell adhesion; Cytoskeletal; Motility/polarity/chemotaxis Q64727 22330 14 A3|14 11.53 cM mouse Y100-p 454004 QMLQSDPySVPARDY Vinculin activity, induced; molecular association, regulation; protein conformation cell motility, induced; cell growth, induced; cell adhesion, induced; cytoskeletal reorganization 26240176; 36207442 4 3 53 -H4c2 H4 DNA-binding P62806 326620 13|13 A3.1 mouse K20-m3 2344825 GGAKRHRkVLRDNIQ CENP-T_C carcinogenesis, induced; chromatin organization, altered; transcription, inhibited; transcription, altered 18728284; 19434510; 20543957; 26304540 35 14 0 -Rps5 RPS5 RNA-binding; Ribosomal; Translation P97461 20103 7|7 A1 mouse T133-p 9819905 TRIGRAGtVRRQAVD Ribosomal_S7 intracellular localization; phosphorylation 19631221 1 1 0 triggers phosphorylation of S23 -HSPB1 HSP27 Chaperone; Heat shock protein; Motility/polarity/chemotaxis; SUMO LIGASE; SUMO ligase Q00649 chicken S81-p 452224 RALSELSsGISEIRQ protein conformation 12429504 3 21 23 Mutations mimicking phosphorylation of sites single (S15D) and in combination form high and low molecular oligomers and affect chaperone activity in vitro. -HDAC4 HDAC4 DEACETYLASE; Deacetylase; EC 3.5.1.98; Hydrolase; Nuclear receptor co-regulator; SUMO LIGASE P56524 9759 2q37.3 human S584-p 41452201 EPGQRQPsEQELLFR activity, induced transcription, inhibited 30661366 1 4 0 transcription of MEF2 target genes RhoB and Klf2 -MCM4 MCM4 DNA replication; EC 3.6.4.12 P33991 4173 8q11.21 human T19-p 448634 GSRRGRAtPAQTPRS activity, inhibited 12714602 3 21 16 -C5AR1 C5aR GPCR, family 1; Membrane protein, integral; Membrane protein, multi-pass; Receptor, GPCR P21730 728 19q13.32 human S317-p 450056 RLRKSLPsLLRNVLT molecular association, regulation ARRB1(INDUCES); ARRB2(INDUCES) 12464600 2 3 0 -IGF1R IGF1R EC 2.7.10.1; KINASE; Kinase, protein; Membrane protein, integral; Protein kinase, TK; Protein kinase, tyrosine (receptor) P08069 3480 15q26.3 human Y1166-p 448388 DIYETDYyRKGGKGL PK_Tyr_Ser-Thr protein conformation; enzymatic activity, induced; phosphorylation autophagy, induced; apoptosis, inhibited; cell growth, altered 11591350; 15334055; 16793764; 34921013; 7798258 16 15 107 -MAP3K14 Nik EC 2.7.11.25; KINASE; Kinase, protein; Protein kinase, STE; Protein kinase, Ser/Thr (non-receptor) Q99558 9020 17q21.31 human T559-p 455390 TGDYIPGtETHMAPE Pkinase enzymatic activity, induced transcription, altered 9742107 3 0 0 -ATG4B ATG4B Autophagy; EC 3.4.22.-; Protease; Ubiquitin conjugating system Q9Y4P1 23192 2q37.3 human S34-p 4750282 WILGRKYsIFTEKDE protein degradation; intracellular localization; enzymatic activity, induced autophagy, induced ATP5C(INDUCES) 29165041; 33607258 2 4 0 increased localization and import to mitochondria; inhibits the F1Fo-ATP synthase activity; promotes p62 degradation; promotes Warburg effect -INSR INSR iso2 EC 2.7.10.1; KINASE; Kinase, protein; Membrane protein, integral; Protein kinase, TK; Protein kinase, tyrosine (receptor) P06213-2 3643 19p13.2 human Y987-p 447685 YASSNPEyLSASDVF activity, induced 1656240 25 0 0 mutation of site impairs insulin stimulation of PI3K activity. -STK38L NDR2 EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, AGC; Protein kinase, Ser/Thr (non-receptor) Q9Y2H1 23012 12p11.23 human T75-p 460299 SQHARKEtEFLRLKR molecular association, regulation; enzymatic activity, induced cell growth, altered S100B(INDUCES) 15037617; 16488889 2 0 0 -FZR1 FZR1 UBIQUITIN LIGASE; Ubiquitin conjugating system Q9UM11 51343 19p13.3 human S42-gl 55596600 SSPVSSPsKHGDRFI activity, induced; molecular association, regulation CDC27(INDUCES) 27080259 1 1 0 promotes the interaction between FZR1 and APC/C subunits, enhances APC/C activity -LAMTOR5 HBXIP Apoptosis; DNA replication O43504 10542 1p13.3 human S26-p 482652 VGVLCTDsQGLNLGC LAMTOR5 molecular association, regulation; intracellular localization; phosphorylation carcinogenesis, induced; transcription, induced Fos(INDUCES) 23667255 1 3 3 phosphorylation of c-Fos -SLBP SLBP RNA-binding Q14493 7884 4p16.3 human S23-p 470508 DGDASPPsPARWSLG protein degradation; ubiquitination 22907757 1 35 28 -Insr INSR EC 2.7.10.1; KINASE; Kinase, protein; Membrane protein, integral; Protein kinase, TK; Protein kinase, tyrosine (receptor) P15208 16337 8 A1.1|8 1.82 cM mouse Y1001-p 449048 DVFPSSVyVPDEWEV signaling pathway regulation 20332342 5 0 2 Rictor/mTORC2 signaling in energy metabolism in fat cells -NFE2L2 NRF2 DNA-binding; Transcription factor Q16236 4780 2q31.2 human T439-p 40642202 VSPGHRKtPFTKDKH intracellular localization 25909891 1 0 0 nuclear translocation -MISP MISP Unknown function Q8IVT2 126353 19p13.3 human S395-p 3205359 GLRRALSsDSILSPA AKAP2_C cytoskeletal reorganization 34023777 1 19 31 -WWTR1 TAZ Oncoprotein; Transcription, coactivator/corepressor Q9GZV5 25937 3q25.1 human Y321-p 27138200 SGLGLGCySVPTTPE intracellular localization carcinogenesis, altered; transcription, induced; signaling pathway regulation 31825826 3 0 0 TAZ target genes transcription and drives lung cancer brain metastases -Chek1 Chk1 EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, CAMK; Protein kinase, Ser/Thr (non-receptor); Tumor suppressor O35280 12649 9|9 A4 mouse S317-p 447833 ETVKFSSsQPEPRTG intracellular localization cell cycle regulation 17242188 103 11 17 -DVL2 DVL2 Adaptor/scaffold; Motility/polarity/chemotaxis O14641 1856 17p13.1 human S435-p 1873559808 KAMAAPEsGLEVRDR molecular association, regulation; protein conformation transcription, induced; signaling pathway regulation DVL2(INDUCES) 34155117 1 1 0 regulates Wnt Signaling -TP53 p53 Activator; DNA-binding; Motility/polarity/chemotaxis; Nuclear receptor co-regulator; Transcription factor; Tumor suppressor P04637 7157 17p13.1 human K120-ub 486293 FLHSGTAkSVTCTYS P53 protein degradation; intracellular localization 17371868; 31492752 2 3 18 -NME1 NME1 EC 2.7.4.6; KINASE; Kinase, nucleoside diphosphate; Kinase, other; Nucleotide Metabolism - purine; Nucleotide Metabolism - pyrimidine; Protein kinase, histidine; Tumor suppressor P15531 4830 17q21.33 human S120-p 450098 GRNIIHGsDSVESAE NDK molecular association, regulation; protein conformation; enzymatic activity, induced cell growth, altered PRUNE(INDUCES) 10602478; 12859952; 17155928; 9038158 6 21 0 inhibits colony formation in soft agar -ARNT ARNT DNA-binding; Motility/polarity/chemotaxis; Transcription factor P27540 405 1q21.3 human S77-p 458309 DKERFARsDDEQSSA protein stabilization; molecular association, regulation; intracellular localization; activity, inhibited transcription, induced; signaling pathway regulation; transcription, inhibited ARNT(INDUCES) 16129408; 34912030; 35290121 3 28 5 -CMKLR1 CMKLR1 GPCR, family 1; Membrane protein, integral; Membrane protein, multi-pass; Receptor, GPCR Q99788 1240 12q23.3 human S345-p 4713121 LSEDTGHsSYPSHRS receptor internalization, induced 24658352 1 1 0 -NADK2 NADK2 EC 2.7.1.23 Q4G0N4 133686 5p13.2 human K304-ac 1195255 DGPWEKQkSSGLNLC enzymatic activity, induced 35868311 1 1 2 K76Q and K304Q mutants reduced proline production, K76Q and K304Q mutants and S116A showed reduced catalytic activity, phosphorylation, succinylation, or acetylation could generate a charge repulsion in the active site -TTK TTK Cancer Testis Antigen (CTA); EC 2.7.12.1; KINASE; Kinase, protein; Protein kinase, Other; Protein kinase, dual-specificity (non-receptor) P33981 7272 6q14.1 human T360-p 1737602 SITLKNKtESSLLAK intracellular localization cell cycle regulation 25265012 3 3 0 autophosphorylation of this site is required for release TTK from kinetochore; causes decreased kinetochore localization of BubR1 and Mad2. -DSP Desmoplakin Cell adhesion; Cytoskeletal; Motility/polarity/chemotaxis P15924 1832 6p24.3 human S2849-p 451165 RSGSRRGsFDATGNS molecular association, regulation cytoskeletal reorganization; cell adhesion, inhibited 25010392; 7525582 3 5 1 DP-S2849G-GFP decreased Dsg3 expression, keratin retraction, increases association of PKC with Rack1; Desmoplakin S2849 phosphorylation may negatively regulate its interaction with the networks of keratin intermediate filaments. -NCOA3 SRC-3 ACETYLTRANSFERASE; Acetyltransferase; EC 2.3.1.48; Motility/polarity/chemotaxis; Nuclear receptor co-regulator; Transcription, coactivator/corepressor Q9Y6Q9 8202 20q13.12 human S1048-p 4252803 PSNLEGQsDERALLD Nuc_rec_co-act protein stabilization; molecular association, regulation PSMA3(DISRUPTS) 18313384 1 0 0 some subset of these 8 residues -FOXA1 FOXA1 DNA-binding; Transcription factor P55317 3169 14q21.1 human K237-ac 11263052 KVARSPDkPGKGSYW Forkhead molecular association, regulation chromatin organization, altered DNA(DISRUPTS) 19897491 1 0 0 -Gabbr2 GABBR2 GPCR, family 3; Membrane protein, integral; Membrane protein, multi-pass; Receptor, GPCR O88871 83633 5q22 rat S883-p 456824 DPIEDINsPEHIQRR signaling pathway regulation 30411139 0 11 4 -STK3 MST2 Autophagy; EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, STE; Protein kinase, Ser/Thr (non-receptor) Q13188 6788 8q22.2 human S385-p 4274113 TMKRNATsPQVQRPS ubiquitination; intracellular localization; phosphorylation cell cycle regulation; carcinogenesis, induced; cell growth, induced 27566175; 37739411 2 27 8 TRIM69 regulates centrosome dynamics and mitotic progression and centrosome amplification, regulates centrosome clustering, promotes triple-negative breast cancer; TRIM69A regulates MST2 ubiquitination and intracellular localization -ATR ATR EC 2.7.11.1; KINASE; Kinase, protein; Membrane protein, integral; Protein kinase, Ser/Thr (non-receptor); Protein kinase, atypical Q13535 545 3q23 human S435-p 477846 SPKRRRLsSSLNPSK molecular association, regulation DNA repair, induced; chromatin organization, altered; signaling pathway regulation XPA(INDUCES); AKAP12(INDUCES) 24950377; 27683220 3 29 72 MC1R signaling enhances NER ; MC1R-cAMP-PKA pathway; suppress UV induced mutagenesis -Slc2a1 GLUT1 Membrane protein, integral; Membrane protein, multi-pass; Transporter; Transporter, SLC family P11167 24778 5q36 rat S226-p 10827359 NEENRAKsVLKKLRG Sugar_tr activity, induced 25982116 1 6 1 glucose uptake -OCLN occludin Cell adhesion; Membrane protein, integral; Membrane protein, multi-pass; Motility/polarity/chemotaxis Q16625 100506658 5q13.2 human S471-p 6094301 LDDYREEsEEYMAAA Occludin_ELL cell growth, induced 27185880 1 1 0 size reductive proliferation after cell contact and bicellular and tricellular tite junction (TJ) maturation, TJ assembly and barrier formation -ARAF ARAF EC 2.7.11.1; KINASE; Kinase, protein; Oncoprotein; Protein kinase, Ser/Thr (non-receptor); Protein kinase, TKL P10398 369 Xp11.3 human S582-p 481007 PKIERSAsEPSLHRT enzymatic activity, induced 18662992 1 69 9 -USP24 USP24 DEUBIQUITINASE; EC 3.4.19.12; Protease; Ubiquitin-specific protease Q9UPU5 23358 1p32.3 human S1616-p 22547101 NSHSPAGsAAISQQD protein degradation cell cycle regulation 27991932 1 2 0 -Cebpb C/EBP-beta DNA-binding; Motility/polarity/chemotaxis; Transcription factor P21272 24253 3q42 rat S105-p 448425 AKPSKKPsDYGYVSL molecular association, regulation cell cycle regulation; cell growth, altered CASP8(INDUCES); CASP1(INDUCES) 10635333; 11684016 5 0 0 -TBK1 TBK1 EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, Other; Protein kinase, Ser/Thr (non-receptor) Q9UHD2 29110 12q14.2 human S527-p 50318715 QDIDSRLsPGGSLAD TBK1_CCD1 protein degradation; ubiquitination transcription, inhibited NALP4(INDUCES) 26407194 1 0 0 inhibited the TBK1-mediated activation of the ISRE and the IFN promoter -Tnnc1 TNNC1 Calcium-binding; Motility/polarity/chemotaxis Q4PP99 rat S89-p 33406500 VRCMKDDsKGKSEEE protein conformation 24708997 1 0 0 T204E mutant blunts Ca2+ sensitivity, PKC phosphorylation of these residues can increase or decrease Ca2+ sensitivity and cardiac regulation -EEF1A1 EEF1A1 Nucleolus; Translation; Translation elongation P68104 1915 6q13 human K36-me 1067201 YKCGGIDkRTIEKFE GTP_EFTU translation, induced 28520920 2 2 0 -Mapt Tau ACETYLTRANSFERASE; Acetyltransferase; Cytoskeletal P19332 29477 10q32.1 rat S573-p 447930 NVRSKIGsTENLKHQ Tubulin-binding molecular association, regulation cytoskeletal reorganization 18245083; 28784767 118 25 2 -Arpp21 ARPP-21 Inhibitor Q9DCB4 74100 9 F3|9 62.46 cM mouse S55-p 1096600 QNQERRKsKSGAGKG molecular association, regulation signaling pathway regulation Calmodulin(INDUCES) 15499021 2 0 0 Regulates PP2B suppression and PKA activation of calcium currents. -TBL1XR1 TBL1XR1 Nuclear receptor co-regulator; Transcription, coactivator/corepressor Q9BZK7 79718 3q26.32 human S199-p 2509603 TARIWNLsENSTSGS transcription, induced 18374649 1 0 0 -Nfya NFYA DNA-binding; Transcription factor P23708 18044 17 C|17 23.99 cM mouse K296-ub 4664703 KIPKERRkYLHESRH CBFB_NFYA protein degradation cell growth, inhibited; transcription, inhibited 18815279 1 0 0 -BLNK BLNK Adaptor/scaffold Q8WV28 29760 10q24.1 human Y72-p 447718 SDDFDSDyENPDEHS molecular association, regulation transcription, altered PLCG1(INDUCES); PLCG2(INDUCES); Btk(INDUCES); NCK2(INDUCES); VAV1(INDUCES) 12456653; 9697839 3 1 0 -GAB2 GAB2 Adaptor/scaffold Q9UQC2 9846 11q14.1 human S623-p 454021 ALDFQPSsPSPHRKP molecular association, regulation SHP-2(DISRUPTS) 15356145 2 6 14 Phosphorylation of this site decreases Gab2 interaction with SHP-2, but leads to increased SHP-2 phosphorylation and activation; also increased phosphorylation of ERK, but decreased activation of STAT5. -TERT TERT iso3 DNA-binding; EC 2.7.7.49; Nucleolus; Transferase O14746-3 7015 5p15.33 human K236-ub 14561001 SRSLPLPkRPRRGAA protein degradation chromatin organization, altered; apoptosis, induced 20453884 1 0 0 -PFN1 profilin 1 Actin-binding; Cytoskeletal; Motility/polarity/chemotaxis P02584 513895 cow Y129-p 450514 GMINKKCyEMASHLR Profilin molecular association, regulation cell motility, induced ACTB(INDUCES) 23000962 4 25 658 promotes actin filament polymerization in vitro -MAPK13 P38D EC 2.7.11.24; KINASE; Kinase, protein; Protein kinase, CMGC; Protein kinase, Ser/Thr (non-receptor) O15264 5603 6p21.31 human Y182-p 454935 ADAEMTGyVVTRWYR Pkinase enzymatic activity, induced 10066767 4 22 997 -Scg5 7B2 Chaperone; Secreted; Secreted, signal peptide P27682 25719 3q35 rat T135-p 25728419 CLENAPDtAEFSREF Secretogranin_V enzymatic activity, induced 25811241 1 2 1 PCSK2 activation -MRE11 MRE11A Cell cycle regulation; DNA repair, damage; DNA-binding; Deoxyribonuclease P49959 4361 11q21 human S649-p 455765 EVIEVDEsDVEEDIF cell cycle regulation; DNA repair, inhibited 28512243 2 38 2 -CENPU CENPU Cell cycle regulation Q71F23 79682 4q35.1 human T98-p 460338 CGLSLSStPPGKEAK molecular association, regulation PLK1(INDUCES) 34551298 1 11 26 -TLX1 TLX1 DNA-binding; Oncoprotein P31314 3195 10q24.31 human T247-p 15660705 MTDAQVKtWFQNRRT Homeodomain molecular association, regulation cell cycle regulation; transcription, altered DNA(NOT_REPORTED) 20846384 1 0 0 -SLC40A1 SLC40A1 Membrane protein, integral; Membrane protein, multi-pass; Transporter; Transporter, SLC family Q9NP59 30061 2q32.2 human Y302-p 25589103 FRDGWVSyYNQPVFL FPN1; TM receptor internalization, inhibited 22682226 1 0 0 regulates internalization partially but not hepcidin mediated internalization -Creb1 CREB iso1 DNA-binding; Transcription factor P15337-1 81646 9q32 rat K136-ac 459099 SRRPSYRkILNDLSS pKID transcription, inhibited 12595525 4 0 0 modulating CREB-mediated gene expression -RPS6KA4 MSK2 EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, AGC; Protein kinase, Ser/Thr (non-receptor) O75676 8986 11q13.1 human T687-p 455803 RSSPPLRtPDVLESS enzymatic activity, induced 11035004 1 26 3 -Fmnl2 FMNL2 Cytoskeletal A2APV2 71409 2|2 C1.1 mouse T202-p 4689209 HSALRYNtLPSRRTL cytoskeletal reorganization 25456499 1 6 1 spine development -ELMO1 ELMO1 Cytoskeletal; Motility/polarity/chemotaxis Q92556 9844 7p14.2-p14.1 human Y511-p 455873 SKLQNLSyTEILKIR molecular association, regulation; intracellular localization cytoskeletal reorganization NCK1(INDUCES); RHOG(INDUCES) 15952790; 24928514 4 2 1 mutation of this site impairs cell migration and phagocytosis; Nck1 enhances ELMO1 and RhoG interaction and promotes Rac1 activity; localization of ELMO1 to the plasma membrane -SIRT2 SIRT2 DEACETYLASE; Deacetylase; EC 3.5.1.- Q8IXJ6 22933 19q13.2 human T101-p 31839907 PDFRSPStGLYDNLE SIR2 molecular association, regulation Akt1(INDUCES) 24446434 1 0 0 -Stx3 STX3 Cell adhesion; Membrane protein, integral; Vesicle Q64704 20908 19|19 A mouse T14-p 31960301 QLKAKQLtQDDDTDE exocytosis, induced 33192329 5 1 0 -PRNP PRNP Membrane protein, GPI anchor; Microtubule-binding P04156 5621 20p13 human S43-p 10273948 SRYPGQGsPGGNRYP protein conformation 25572400 2 2 0 exacerbate PRNP mutant conversion -NIFK NIFK Nucleolus; RNA-binding Q9BYG3 84365 2q14.3 human T234-p 449332 TVDSQGPtPVCTPTF hNIFK_binding molecular association, regulation KI-67(INDUCES) 11342549; 16244663 2 27 77 -Cacng2 Stargazin Channel, calcium; Membrane protein, integral; Membrane protein, multi-pass Q71RJ2 84347 7q34 rat S247-p 455319 SSRSTEPsHSRDASP molecular association, regulation neural plasticity PSD-95(INDUCES) 25843401 3 0 0 -GATA1 GATA1 DNA-binding; Transcription factor P15976 2623 Xp11.23 human K245-ac 466357 NRPLIRPkKRLIVSK molecular association, regulation transcription, altered DNA(INDUCES) 16888089 3 1 0 -PRKCZ PKCZ EC 2.7.11.13; KINASE; Kinase, protein; Protein kinase, AGC; Protein kinase, Ser/Thr (non-receptor) Q05513 5590 1p36.33 human T560-p 447572 TSEPVQLtPDDEDAI Pkinase_C protein conformation; phosphorylation carcinogenesis, induced; cytoskeletal reorganization; signaling pathway regulation TNNI1(INDUCES); desmin(INDUCES); TPM1(INDUCES); MYO1C(INDUCES); TNNT1(INDUCES) 17724026; 25002577; 32559461 13 8 0 regulates mTORC2-PKC?-cPLA2 signaling -IRF3 IRF3 DNA-binding; Transcription factor Q14653 3661 19q13.33 human S385-p 448696 MARVGGAsSLENTVD activity, induced; molecular association, regulation; intracellular localization; protein conformation; enzymatic activity, induced transcription, induced; transcription, altered CBP(DISRUPTS); IRF3(INDUCES); p300(INDUCES) 10920266; 14703513; 17526488; 18272581; 18440553; 31882361; 35948267; 9463386 12 3 0 -CDC25C CDC25C EC 3.1.3.48; Motility/polarity/chemotaxis; PHOSPHATASE; Protein phosphatase, dual-specificity P30307 995 5q31.2 human T236-p 451436 VEKFKDNtIPDKVKK M-inducer_phosp molecular association, regulation; intracellular localization KPNB3(DISRUPTS) 15064744 1 0 0 -MAFG MAFG Cell cycle regulation; DNA-binding O15525 4097 17q25.3 human K14-sm 12004419 GNKALKVkREPGENG transcription, inhibited 16738329 1 2 0 -GSTP1 GSTP1 EC 2.5.1.18; Other Amino Acids Metabolism - glutathione; Transferase; Xenobiotic Metabolism - drug metabolism - cytochrome P450; Xenobiotic Metabolism - metabolism by cytochrome P450 P09211 2950 11q13.2 human S185-p 455118 SAYVGRLsARPKLKA GST_C_3 activity, induced; molecular association, regulation; intracellular localization HMGB1(INDUCES) 15604283; 29520271 2 0 0 nuclear translocation -Nfkb1 NFkB-p105 DNA-binding; Transcription factor P25799 18033 3 G3|3 62.82 cM mouse S335-p 449967 FVQLRRKsDLETSEP RHD_dimer molecular association, regulation; protein conformation transcription, altered NFkB-p105(DISRUPTS) DNA(DISRUPTS) 29873020 5 1 0 -MAP2K1 MEK1 EC 2.7.12.2; KINASE; Kinase, protein; Protein kinase, STE; Protein kinase, dual-specificity (non-receptor) Q02750 5604 15q22.31 human T388-p 466978 LNQPSTPtHAAGV__ intracellular localization 18760948 2 1 15 nuclear translocation -ACSL4 ACSL4 EC 6.2.1.3; Ligase; Lipid Metabolism - fatty acid; Membrane protein, integral O60488 2182 Xq23 human K690-ub 21128156 GLVTDAFkLKRKELR protein degradation 37428466 1 2 0 inhibition of ACSL4-driven lipid peroxidation and ferroptosis is necessary for CDK1 to promote oxaliplatin resistance in CRC -G3BP1 G3BP-1 Adaptor/scaffold; EC 3.6.4.12; EC 3.6.4.13; Helicase; RNA-binding Q13283 10146 5q33.1 human S149-p 449041 VTEPQEEsEEEVEEP molecular association, regulation; intracellular localization; activity, inhibited; protein conformation carcinogenesis, induced; cell motility, induced; cell growth, induced; apoptosis, inhibited; cytoskeletal reorganization G3BP-1(DISRUPTS); CAPRIN1(DISRUPTS); USP10(INDUCES) RNA(DISRUPTS) 11604510; 12642610; 27022092; 27083003; 32302571; 32302572; 33065005; 36922679 12 87 53 induces ESM1 stabilization -Irs2 IRS2 Adaptor/scaffold; Motility/polarity/chemotaxis P81122 384783 8 A1.1|8 5.35 cM mouse S556-p 470895 GRPYRRVsGDGAQDL protein degradation cell cycle regulation 25830382 2 51 10 -AQP5 AQP5 Channel, misc.; Membrane protein, integral; Membrane protein, multi-pass; Transporter; Transporter, aquaporin family P55064 362 12q13.12 human S156-p 1233703 STDSRRTsPVGSPAL MIP activity, induced; intracellular localization; phosphorylation cell cycle regulation; cell motility, induced LYN(INDUCES); Src(INDUCES); GADS(INDUCES) 18478076; 18583321; 26569106 5 0 0 increases posphorylation of Rb at S780; S156 to glutamate (S156E) increased constitutive membrane expression of AQP5, increased membrane expression by PKA inhibitory peptide; affects cell proliferation; stimulates cells to undergo epithelial-mesenchymal transition (EMT) -MCM2 MCM2 DNA-binding; EC 3.6.4.12 P49736 4171 3q21.3 human S139-p 454180 RRGLLYDsDEEDEER MCM2_N activity, induced; molecular association, regulation cell cycle regulation; chromatin organization, altered SIRT1(INDUCES) DNA(NOT_REPORTED); DNA(INDUCES) 16446360; 16899510; 35524559 7 99 323 -STAT3 STAT3 DNA-binding; Motility/polarity/chemotaxis; Nuclear receptor co-regulator; Transcription factor P40763 6774 17q21.2 human K451-sm 56403902 EVYHQGLkIDLETHS STAT_bind molecular association, regulation; phosphorylation carcinogenesis, inhibited; transcription, inhibited PTPN2(INDUCES) 27181202 1 0 0 SENP deconjugates SUMO and inhibits STAT3 association with phosphatase PTPN2, enhancing phosphorylation at Y705 -TRPA1 TRPA1 Membrane protein, integral; Membrane protein, multi-pass O75762 8989 8q21.11 human S602-p 1871177701 VVLTIIRsKRWDECL Ank_2 protein conformation; activity, inhibited 33121177 1 0 0 inactivate human TRPA1 channel -MAF1 MAF1 Transcription regulation Q9H063 84232 8q24.3 human S75-p 477954 SPSRLSKsQGGEEEG Maf1 protein degradation; ubiquitination; activity, inhibited transcription, induced; transcription, altered 20233713; 20516213; 20543138; 31645432 4 33 54 regulates sensitivity of cells for doxorubicin -NFKBIA IkB-alpha DNA-binding; Inhibitor P25963 4792 14q13.2 human K22-ub 485774 GPRDGLKkERLLDDR activity, induced; protein degradation; ubiquitination; intracellular localization transcription, induced 7479976; 8550590; 8649784; 9724653; 9990853 9 0 0 -DYRK2 DYRK2 iso2 EC 2.7.12.1; KINASE; Kinase, protein; Protein kinase, CMGC; Protein kinase, dual-specificity (non-receptor) Q92630-2 8445 12q15 human S489-p 1874397816 ESTGAITsISKLPPP intracellular localization cell cycle regulation; apoptosis, induced 34363019 1 1 0 -SMN1 SMN RNA processing; RNA-binding Q16637 6606 5q13.2 human T68-p 23299103 ETSGKPKtTPKRKPA SMN molecular association, regulation; intracellular localization coilin(INDUCES) 24602413 1 1 1 -APP APP Apoptosis; Cell surface; Membrane protein, integral; Receptor, misc.; Transcription factor P05067 351 21q21.3 human K751-ub 3932067 PEERHLSkMQQNGYE APP_amyloid protein processing; intracellular localization 29021256 2 8 39 An APP mutant that lacks all C-terminal lysines increased PSEN2-mediated processing of an increased pool of APP on the endosomal membrane. -Arpp19 ARPP-19 Cell cycle regulation; Phosphatase, regulatory subunit P56212 59046 9|9 D mouse S62-p 465742 KGQKYFDsGDYNMAK Endosulfine enzymatic activity, inhibited 28167675 3 70 47 inhibits PP2A activity -CLOCK CLOCK ACETYLTRANSFERASE; Acetyltransferase; DNA-binding; EC 2.3.1.48; Transcription factor O15516 9575 4q12 human S431-p 11087834 FDHSPTPsASSRSSR protein degradation; phosphorylation transcription, altered 19946213 1 1 0 -NEU3 NEU3 EC 3.2.1.18; Glycan Metabolism - other glycan degradation; Hydrolase; Lipid Metabolism - sphingolipid Q9UQ49 10825 11q13.4 human Y346-p 450320 QRVDLGIyLNQTPLE BNR_2 molecular association, regulation; phosphorylation GRB2(INDUCES) 12730204 1 0 0 lowers IRS-1 phosphorylation -CTTN Cortactin Actin-binding; Cytoskeletal; Motility/polarity/chemotaxis Q14247 2017 11q13.3 human T401-p 449245 QARAKTQtPPVSPAP intracellular localization 27758765 2 95 117 -PRKCA PKCA EC 2.7.11.13; KINASE; Kinase, protein; Oncoprotein; Protein kinase, AGC; Protein kinase, Ser/Thr (non-receptor) P17252 5578 17q24.2 human S657-p 448597 QSDFEGFsYVNPQFV Pkinase_C intracellular localization; phosphorylation; enzymatic activity, induced carcinogenesis, induced; cell growth, induced; cytoskeletal reorganization; signaling pathway regulation 17504762; 22521536; 35132180 28 4 2 -Opn4 melanopsin GPCR, family 1; Membrane protein, integral; Membrane protein, multi-pass; Receptor, GPCR Q9QXZ9 30044 14|14 B mouse S379-p 1868515103 SGQRSHPsLSYRSTH protein conformation 32236094 1 1 0 -PRL prolactin Cytokine; Motility/polarity/chemotaxis; Secreted; Secreted, signal peptide P01236 5617 6p22.3 human S179-p 17790903 NEIYPVWsGLPSLQM Hormone_1 phosphorylation cell cycle regulation; apoptosis, induced; cell growth, inhibited; transcription, induced; cell motility, inhibited; transcription, inhibited; signaling pathway regulation 12970160; 16103106; 16601282; 16840547; 17911340; 20013077 9 0 0 upregulates p21; ; upregulates VDR and promotes its nuclear translocation -WRN WRN Cell cycle regulation; DNA repair, damage; DNA-binding; EC 3.6.4.12; Helicase; Nucleolus Q14191 7486 8p12 human K1413-ac 486391 RLPVWFAkGSDTSKK protein stabilization; ubiquitination 20428248 1 1 0 inhibits ubiquitination -ALDH1B1 ALDH1B1 Amino Acid Metabolism - arginine and proline; Amino Acid Metabolism - histidine; Amino Acid Metabolism - lysine degradation; Amino Acid Metabolism - tryptophan; Amino Acid Metabolism - valine, leucine and isoleucine degradation; Carbohydrate Metabolism - ascorbate and aldarate; Carbohydrate Metabolism - butanoate; Carbohydrate Metabolism - glycolysis and gluconeogenesis; Carbohydrate Metabolism - propanoate; Carbohydrate Metabolism - pyruvate; EC 1.2.1.3; Lipid Metabolism - fatty acid; Lipid Metabolism - glycerolipid; Mitochondrial; Other Amino Acids Metabolism - beta-alanine; Oxidoreductase; Secondary Metabolites Metabolism - limonene and pinene degradation P30837 219 9p13.1 human K511-ub 1881380902 EVKTVTIkVPQKNS_ molecular association, regulation transcription, inhibited ALDH1B1(DISRUPTS) 34769507 1 0 0 AMBRA1-mediated ubiquitylation of ALDH1B1 inhibitss the self-association of ALDH1B1 and the transcription of PTEN -TPX2 TPX2 Cell cycle regulation; Microtubule-binding Q9ULW0 22974 20q11.21 human T369-p 455432 KICRDPQtPVLQTKH TPX2_importin activity, induced; intracellular localization cell cycle regulation 27551054 2 25 129 recruitment to the anaphase spindle -AXIN1 axin 1 iso2 Adaptor/scaffold; Tumor suppressor O15169-2 8312 16p13.3 human K789-ub 40212803 GSYRYYFkKVSDEFD DIX molecular association, regulation signaling pathway regulation LRP5(DISRUPTS); LRP6(DISRUPTS) 23959799 1 0 0 regulates Wnt/beta-catenin signaling, inhibits LRP6 phosphorylation -IRF3 IRF3 DNA-binding; Transcription factor Q14653 3661 19q13.33 human K70-sm 25174502 AYVPGRDkPDLPTWK IRF protein stabilization; ubiquitination 22028379 1 0 0 deSUMOylation promotes ubiquitination and degradation at the same residues -NADK NADK Cofactor and Vitamin Metabolism - nicotinate and nicotinamide; EC 2.7.1.23; Kinase, other O95544 65220 1p36.33 human S46-p 1210510 RGRAKSRsLSASPAL phosphorylation; enzymatic activity, induced carcinogenesis, induced 34133937 1 22 8 primes for phosphorylation at S64 -ERBB4 HER4 EC 2.7.10.1; KINASE; Kinase, protein; Membrane protein, integral; Protein kinase, TK; Protein kinase, tyrosine (receptor) Q15303 2066 2q34 human Y1284-p 457470 IVAENPEyLSEFSLK molecular association, regulation; enzymatic activity, induced cell growth, induced; apoptosis, inhibited SHC1(INDUCES) 16729043; 19718025 6 2 7 -PLN PLB Inhibitor; Membrane protein, integral P61015 rabbit S16-p 448114 RSAIRRAsTIEMPQQ Phospholamban activity, induced 21555709 78 15 66 induces SERCA2 activity -YWHAE 14-3-3 epsilon Adaptor/scaffold P62258 7531 17p13.3 human K50-ac 11315836 NLLSVAYkNVIGARR 14-3-3 molecular association, regulation; intracellular localization SFRS6(DISRUPTS); PLEKHQ1(DISRUPTS); SFRS4(DISRUPTS); DOK3(DISRUPTS); TSC2(DISRUPTS); ARAF(DISRUPTS); LARP(DISRUPTS); SRm300(DISRUPTS); SF2(DISRUPTS); TSC22D1(DISRUPTS); YAP1(DISRUPTS); GAB2(DISRUPTS); RAF1(DISRUPTS); VASP(DISRUPTS); HDAC4(DISRUPTS); TRA2B(DISRUPTS); GBF1(DISRUPTS) 19608861; 36341908 1 4 13 -SNAP23 SNAP23 Vesicle O00161 8773 15q15.1-q15.2 human S95-p 455262 NRTKNFEsGKAYKTT SNAP-25 molecular association, regulation; intracellular localization; protein conformation autophagy, induced; exocytosis, induced; endocytosis, inhibited STX17(INDUCES) 28067230; 29771640; 32949647; 33213278 14 4 2 -Sdha SDHA Carbohydrate Metabolism - citrate (TCA) cycle; EC 1.3.5.1; Energy Metabolism - oxidative phosphorylation; Mitochondrial; Oxidoreductase; Tumor suppressor Q8K2B3 66945 13|13 C1 mouse Y604-p 1458603 YKVRVDEyDYSKPIQ Succ_DH_flav_C activity, induced 24856931 3 2 2 induce complex II activation -CEACAM1 CEACAM1 iso8 Cell adhesion; Immunoglobulin superfamily; Membrane protein, integral; Motility/polarity/chemotaxis P13688-8 634 19q13.2 human T457-p 3439801 CFLHFGKtGSSGPLQ phosphorylation cell differentiation, altered 17546042 5 1 0 FAK Y397 phosphorylation -ERF ERF DNA-binding; Transcription factor P50548 2077 19q13.2 human S246-p 456967 RGGPEPLsPFPVSPL intracellular localization cell cycle regulation 10330152; 14729966 2 1 0 -Nos1 nNOS Amino Acid Metabolism - arginine and proline; EC 1.14.13.39; Oxidoreductase P29476 24598 12q16 rat K754-ac 2459107 QAMAKRVkATILYAT activity, induced 18415985 1 1 0 -PKD1 PKD1 Cell adhesion; Membrane protein, integral; Membrane protein, multi-pass P98161 5310 16p13.3 human S4166-p 2859800 EPLPSRSsRGSKVSP cell differentiation, altered 17980165 1 0 0 -Stk11 LKB1 Autophagy; EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, CAMK; Protein kinase, Ser/Thr (non-receptor); Tumor suppressor Q9WTK7 20869 10|10 C1 mouse Y36-p 14575494 IDSTEVIyQPRRKRA molecular association, regulation; intracellular localization cell differentiation, induced; signaling pathway regulation PLCG1(INDUCES); LAT(INDUCES) 21487392 1 5 12 TCR signaling, recruitment of PLCG1 to the LAT signalosome -NQO1 NQO1 EC 1.6.5.2; Oxidoreductase P15559 1728 16q22.1 human S40-p 23255660 KGWEVVEsDLYAMNF Flavodoxin_2 protein degradation; protein conformation 36096178 2 0 1 -EZH2 EZH2 EC 2.1.1.43; METHYLTRANSFERASE; Methyltransferase; Methyltransferase, protein lysine Q15910 2146 7q36.1 human T345-p 4957354 LTAERIKtPPKRPGG protein degradation; molecular association, regulation; ubiquitination; protein conformation carcinogenesis, induced; carcinogenesis, altered; cell growth, induced; cell motility, altered; transcription, altered; cell growth, altered SUZ12(INDUCES); H3(INDUCES); AR(INDUCES) RNA(INDUCES) 20935635; 21659531; 25800736; 27716745; 34489572; 35682829 11 12 2 -STING1 STING Apoptosis; Endoplasmic reticulum; Membrane protein, integral; Membrane protein, multi-pass; Mitochondrial Q86WV6 340061 5q31.2 human S358-p 13201900 VPSTSTMsQEPELLI activity, induced; molecular association, regulation TBK1(INDUCES) 18818105; 22579474 4 1 0 with c-di-GMP, S358A shows weaker binding; activates IRF-E and enhances interaction between TBK1 and IRF3.; truncated STING (residues 139?344 only) showed additional binding sites -IRF2 IRF2 DNA-binding; Transcription factor P14316 3660 4q35.1 human K75-ac 459110 GVDKPDPkTWKANFR IRF cell growth, induced; transcription, induced 12738767 1 1 0 acetylated in a cell growth-dependent manner -Ocln occludin Cell adhesion; Membrane protein, integral; Membrane protein, multi-pass; Motility/polarity/chemotaxis Q61146 18260 13 D1|13 53.23 cM mouse S489-p 6094300 RLKQVKGsADYKSKR Occludin_ELL intracellular localization endocytosis, induced; cell motility, induced; cell growth, induced 27423695; 33883214 11 1 0 VEGF-induced tube formation, VEGF-induced tube formation, localizes to centrosomes, retinal neovascularization; regulates VEGF induced retinal permeability, BRB permeability and leukostasis induced by diabetes -LRP1 LRP1 Cell surface; Membrane protein, integral; Motility/polarity/chemotaxis; Receptor, misc. Q07954 4035 12q13.3 human Y4507-p 451245 TNFTNPVyATLYMGG molecular association, regulation; protein conformation SHC1(INDUCES); SHP-2(INDUCES); Fe65(INDUCES) 11854294; 18381291; 21650223 6 1 0 only binds when Fe65 is in complex with APP -SHC3 SHC3 iso2 Adaptor/scaffold; Motility/polarity/chemotaxis Q92529-2 53358 9q22.1 human Y283-p 451257 RQGSSDIySTPEGKL molecular association, regulation CRK(INDUCES); RAPGEF1(INDUCES) 11791173 1 3 27 -AGTR1 AT1 GPCR, family 1; Membrane protein, integral; Membrane protein, multi-pass; Receptor, GPCR P30556 185 3q24 human S335-p 467238 SNLSTKMsTLSYRPS activity, induced; molecular association, regulation; intracellular localization; receptor internalization, altered ARRB1(INDUCES); ARRB2(INDUCES) 11579203; 15177932 3 1 0 -CERK CERK EC 2.7.1.138; Kinase, lipid; Lipid Metabolism - sphingolipid Q8TCT0 64781 22q13.31 human S427-p 11485304 LILIRKCsRFNFLRF CERK_C enzymatic activity, induced 19899769 1 0 0 -DAB2 DAB2 Adaptor/scaffold; Tumor suppressor P98082 1601 5p13.1 human S393-p 483635 QNGFSVKsSPNPFVG molecular association, regulation CLTA(INDUCES) 21097498 1 5 0 -Crtc2 TORC2 Transcription, coactivator/corepressor Q3U182 74343 3|3 F1 mouse S275-p 3174300 PAMNTGGsLPDLTNL TORC_M molecular association, regulation; intracellular localization carcinogenesis, inhibited; transcription, inhibited; transcription, altered 14-3-3 beta(INDUCES) 18626018; 26342077; 29941929; 33127851 6 0 0 -HDAC6 HDAC6 DEACETYLASE; Deacetylase; EC 3.5.1.98; Nuclear receptor co-regulator; Ubiquitin conjugating system Q9UBN7 10013 Xp11.23 human S22-p 453006 RSRQNPQsPPQDSSV molecular association, regulation; acetylation; enzymatic activity, induced Tau(INDUCES); SNCA(INDUCES) 31363957; 32655357 5 35 18 -PCK2 PCK2 Carbohydrate Metabolism - citrate (TCA) cycle; Carbohydrate Metabolism - glycolysis and gluconeogenesis; Carbohydrate Metabolism - pyruvate; EC 4.1.1.32; Kinase, other; Lyase; Mitochondrial Q16822 5106 14q11.2-q12 human K491-ac 54531208 AAAEHKGkIIMHDPF PEPCK_GTP protein stabilization carcinogenesis, induced; signaling pathway regulation 34166767 1 2 0 Isoenzyme transition from PCK1 to PCK2; gluconeogenesis from glutamine and lactate enhanced tolerance to sorafenib; development of sorafenib-resistant liver cancer cell; nonacetylated form of PCK2 was degraded via lysosomes -Creb1 CREB DNA-binding; Transcription factor Q01147 12912 1 C2|1 32.74 cM mouse S119-p 448228 EILSRRPsYRKILND pKID activity, induced; acetylation; molecular association, regulation; protein conformation; phosphorylation carcinogenesis, induced; apoptosis, induced; transcription, induced; signaling pathway regulation; transcription, altered; neural plasticity; exocytosis, induced; autophagy, inhibited; transcription, inhibited; cell growth, altered; translation, inhibited CREM iso2(INDUCES); MyoD(INDUCES); SIRT1(INDUCES); p300(INDUCES); CREB(DISRUPTS); CBP(INDUCES) DNA(DISRUPTS) 10669737; 10722651; 12091337; 12665587; 15590637; 17196532; 17344422; 17616745; 18356083; 19041748; 20952540; 23241891; 26804914; 27095572; 32358047; 32776935; 32878981; 34171357; 34193609; 34348143; 34425033; 34607805; 34695513; 34750263; 36049536; 36090685; 36516759; 36736425; 36995368; 37028428; 8552098 311 5 61 in vitro and in vivo -EDNRA EDNRA GPCR, family 1; Membrane protein, integral; Membrane protein, multi-pass; Motility/polarity/chemotaxis; Receptor, GPCR P25101 1909 4q31.22-q31.23 human S420-p 2911706 NNHNTDRsSHKDSMN receptor desensitization, induced 24064210 1 1 0 Lack of S397, T403 and S404 influences desensitization to a greater extent compared than S391, S393, and T396 -DDR1 DDR1 EC 2.7.10.1; KINASE; Kinase, protein; Membrane protein, integral; Protein kinase, TK; Protein kinase, tyrosine (receptor) Q08345 780 6p21.33 human Y792-p 462055 FGMSRNLyAGDYYRV PK_Tyr_Ser-Thr activity, induced carcinogenesis, induced; cell adhesion, induced; signaling pathway regulation 24509848; 31979355 1 17 926 -Foxo3 FOXO3A Autophagy; DNA-binding; Oncoprotein; Transcription factor Q9WVH4 56484 10 B2|10 22.79 cM mouse S573-p 20799900 SAKHQQQsPASQSMQ activity, induced transcription, induced; signaling pathway regulation 33649241 5 2 0 upregulates miR-34b and miR-34c expression; inhibits PDGF pathway -Gria1 GluR1 Channel, calcium; Channel, ligand-gated; Membrane protein, integral; Membrane protein, multi-pass P23818 14799 11 B1.3|11 34.51 cM mouse S857-p 3362102 INEAIRTsTLPRNSG activity, induced 17689977 1 0 0 synaptic plasticity -Nbn NBS1 Cell cycle regulation; DNA repair, damage Q9R207 27354 4|4 A2 mouse T278-p 449968 VDVGITNtQLIISHS NIBRIN_BRCT_II DNA repair, induced 21664921 10 0 0 delayed phosphorylation of Chk2 and Smc1 -YBX1 YB-1 RNA processing; RNA splicing; RNA-binding; Transcription factor P67809 4904 1p34.2 human S165-p 469054 YQQNYQNsESGEKNE intracellular localization cell growth, induced; transcription, induced 26318844; 28077578 2 78 31 -EP300 p300 ACETYLTRANSFERASE; Acetyltransferase; EC 2.3.1.48; Motility/polarity/chemotaxis; Nuclear receptor co-regulator; Transcription, coactivator/corepressor Q09472 2033 22q13.2 human S1038-p 10941006 STSATQSsPAPGQSK protein degradation; acetylation cell cycle regulation; carcinogenesis, induced; chromatin organization, altered; cell motility, induced; cell growth, induced; transcription, inhibited 24530506 1 27 0 Decrease histone H3-acetylation -SMAD2 SMAD2 DNA-binding; Transcription factor Q15796 4087 18q21.1 human T220-p 448793 QSNYIPEtPPPGYIS activity, induced; protein stabilization; molecular association, regulation; intracellular localization carcinogenesis, induced; cell differentiation, induced; transcription, induced; signaling pathway regulation SETD2(INDUCES); SMAD4(INDUCES) RNA(INDUCES) 10197981; 12193595; 27153775; 31995604; 33051597 12 0 0 TGFB1 signaling -JUP CTNNG Cytoskeletal; Motility/polarity/chemotaxis P14923 3728 17q21.2 human Y550-p 456972 AAGTQQPyTDGVRME molecular association, regulation transcription, induced Desmoplakin(DISRUPTS); CTNNA1(INDUCES) 14517306 1 4 136 -TBK1 TBK1 EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, Other; Protein kinase, Ser/Thr (non-receptor) Q9UHD2 29110 12q14.2 human Y394-p 126839800 LNTIGLIyEKISLPK TBK1_ULD enzymatic activity, inhibited; protein conformation 28618271 2 1 0 suppress antiviral defenses -CD300LF IREM-1 Immunoglobulin superfamily; Membrane protein, integral; Receptor, misc. Q8TDQ1 146722 17q25.1 human Y284-p 474547 GPEEPTEySTISRP_ activity, induced; molecular association, regulation SHP-1(INDUCES) 17202342 2 0 0 mutation of site to Phe decreased the inhibitory activity of IREM-1 -NPHP1 NPHP1 Cell adhesion O15259 4867 2q13 human Y721-p 18449509 FDLSEQTyDFLGEMR molecular association, regulation; intracellular localization PACS-1(INDUCES) 21357692 1 0 0 -TPPP TPPP Cytoskeletal O94811 11076 5p15.33 human S32-p 456613 DRAAKRLsLESEGAG acetylation; phosphorylation transcription, induced 23727580 2 36 5 decreases B-Catennin phosphorylation and acetylation and induces its expression -NME1 NME1 EC 2.7.4.6; KINASE; Kinase, nucleoside diphosphate; Kinase, other; Nucleotide Metabolism - purine; Nucleotide Metabolism - pyrimidine; Protein kinase, histidine; Tumor suppressor P15531 4830 17q21.33 human K85-ub 15393712 WEGLNVVkTGRVMLG NDK protein degradation cell motility, induced 25582197 1 1 1 -Dcx Doublecortin iso3 Cytoskeletal; Motility/polarity/chemotaxis Q9CXL6 13193 X|X F2 mouse S327-p 451363 STPKSKQsPISTPTS cell motility, induced; cytoskeletal reorganization 25073924; 33405953 7 4 14 -ABI1 Abi-1 Adaptor/scaffold; Motility/polarity/chemotaxis Q8IZP0 10006 10p12.1 human K116-ac 1881343400 IGILTTNkNTSRTHK molecular association, regulation; phosphorylation N-WASP(INDUCES) 34369620 1 0 0 -Cacna1c CACNA1C iso5 Channel, calcium; Membrane protein, integral; Membrane protein, multi-pass Q0PCR6 12288 6 F1|6 55.86 cM mouse S1700-p 4714250 PEIRRAIsGDLTAEE CAC1F_C activity, induced 24218620; 25368181 17 7 0 increased channel current and contractility in response to beta-adrenergic stimulation, exercise capacity and cardiac function in vivo; channel activity, regulates fight-or-flight response, blocking induces cardiac hypertrophy -NCOA3 SRC-3 ACETYLTRANSFERASE; Acetyltransferase; EC 2.3.1.48; Motility/polarity/chemotaxis; Nuclear receptor co-regulator; Transcription, coactivator/corepressor Q9Y6Q9 8202 20q13.12 human K786-ub 1505897101 QEKDPKIkTETSEEG DUF4927 activity, induced; protein degradation; molecular association, regulation; ubiquitination transcription, induced; signaling pathway regulation ER-alpha(INDUCES) 17574025 1 0 0 -Tnnt2 TNNT2 Motility/polarity/chemotaxis; Motor P50752 21956 1 E4|1 59.32 cM mouse T297-p 451557 TRGKAKVtGRWK___ Troponin phosphorylation cytoskeletal reorganization 15774859 6 0 0 ROCK II induced desensitization to Ca++ and depression in maximal tension. -Cish CISH O70512 83681 8q32 rat K207-ub 37044802 VATAVHLkLVQPFVR protein degradation 25448846 1 0 0 -SNAI1 Snail1 C2H2-type zinc finger protein; Transcription factor O95863 6615 20q13.13 human K234-sm 1873356100 LQTHSDVkKYQCQAC molecular association, regulation; intracellular localization carcinogenesis, induced; cell motility, induced; transcription, induced Jun(INDUCES) 29228645 1 0 0 -HDAC4 HDAC4 DEACETYLASE; Deacetylase; EC 3.5.1.98; Hydrolase; Nuclear receptor co-regulator; SUMO LIGASE P56524 9759 2q37.3 human S298-p 1322400 ACSSAPGsGPSSPNN protein degradation; ubiquitination; intracellular localization cell motility, altered 18045992; 21118993 2 0 0 -Trpv1 TRPV1 Channel, cation; Membrane protein, integral; Membrane protein, multi-pass; Receptor, misc. Q704Y3 193034 11 B4|11 45.25 cM mouse T407-p 473576 IAYSSSEtPNRHDML activity, induced 23668392 5 0 0 potentiates Ca2+ influx -ACSS2 ACSS2 Carbohydrate Metabolism - glycolysis and gluconeogenesis; Carbohydrate Metabolism - propanoate; Carbohydrate Metabolism - pyruvate; EC 6.2.1.1; Ligase Q9NR19 55902 20q11.22 human S659-p 83970101 PGLPKTRsGKIMRRV AMP-binding_C molecular association, regulation; intracellular localization autophagy, induced; transcription, induced KPNA5(INDUCES) 28552616; 28820290 3 1 0 nuclear translocation -Tcf7 TCF7 DNA-binding; Transcription factor Q00417 21414 11 B1.3|11 31.86 cM mouse K99-ub 41496498 SQRLFPDkLPESLED CTNNB1_binding protein stabilization cell growth, induced 31488580 1 3 0 -DBNL DBNL Actin-binding; Motility/polarity/chemotaxis Q9UJU6 28988 7p13 human S269-p 467729 KQKERAMsTTSISSP molecular association, regulation signaling pathway regulation 14-3-3 beta(INDUCES); 14-3-3 theta(INDUCES); HPK1(INDUCES) 21725060; 36639542 2 65 464 inhibits the MAP4K1/JNK/GPX4 cell death pathway; mutation of this site prevents 14-3-3 binding (pan-14-3-3 antibody) -Kcnd2 Kv4.2 Channel, potassium; Membrane protein, integral; Membrane protein, multi-pass Q9Z0V2 16508 6 A2-A3.1|6 8.49 cM mouse K437-sm 1879723000 LARIRAAkSGSANAY intracellular localization 31213982 2 0 0 increase in Kv4.2 surface expression -DCP1A DCP1A EC 3.-.-.-; Hydrolase; RNA processing; Transcription, coactivator/corepressor Q9NPI6 55802 3p21.1 human S315-p 3213294 PTYTIPLsPVLSPTL intracellular localization RNA stability, induced; transcription, altered 21859862 4 29 10 -NAA10 NAA10 ACETYLTRANSFERASE; Acetyltransferase; Amino Acid Metabolism - phenylalanine; Amino Acid Metabolism - tyrosine; EC 2.3.1.88; Lipid Metabolism - glycerophospholipid; Secondary Metabolites Metabolism - limonene and pinene degradation P41227 8260 Xq28 human K136-ac 461869 QISEVEPkYYADGED enzymatic activity, induced carcinogenesis, induced; cell growth, induced; transcription, induced; signaling pathway regulation 20501853 2 4 11 regulates AP1 pathway activation mediated by ERK1/2 -Oxsr1 OSR1 EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, STE; Protein kinase, Ser/Thr (non-receptor) Q6P9R2 108737 9|9 F3 mouse T185-p 456503 TRNKVRKtFVGTPCW Pkinase enzymatic activity, induced cell motility, induced 21486947; 27400149 12 6 51 -GRB2 GRB2 Adaptor/scaffold; Cell development/differentiation; Motility/polarity/chemotaxis P62993 2885 17q25.1 human Y160-p 452038 QVPQQPTyVQALFDF molecular association, regulation; protein conformation cell growth, inhibited; cell growth, induced; signaling pathway regulation GRB2(DISRUPTS); EGFR(DISRUPTS) 26103942; 33795832; 35507881; 36163549 6 4 34 -DOCK2 DOCK2 Adaptor/scaffold; GAP; GAP, Rac/Rho; Motility/polarity/chemotaxis Q92608 1794 5q35.1 human Y1405-p 1876205002 VKNAPGQyIQCFTVQ DHR-2_Lobe_B molecular association, regulation; intracellular localization; enzymatic activity, induced transcription, induced; signaling pathway regulation RAC1(INDUCES) 35079145 1 1 0 induces RAC1 GTPase recruitment and activation further inducing CLR signaling -IRX2 IRX2 DNA-binding; Transcription factor Q9PU52 373975 chicken S326-p 452193 AALGGRAsPGPPTPA transcription, altered 15133517 1 1 0 -UIMC1 RAP80 Nuclear receptor co-regulator; Transcription, coactivator/corepressor Q96RL1 51720 5q35.2 human K112-ub 573781876 EEEELLRkAIAESLN RAP80_UIM intracellular localization; enzymatic activity, inhibited 35938958 1 3 0 -Cnr1 CNR1 GPCR, family 1; Membrane protein, integral; Membrane protein, multi-pass; Receptor, GPCR P47746 12801 4 A5|4 16.28 cM mouse S465-p 22342302 AKVTMSVsTDTSAEA receptor desensitization, induced 22014214 1 0 1 -H2az1 H2AZ DNA-binding P0C0S6 51788 3|3 G3 mouse K115-ub 486330 GVIPHIHkSLIGKKG Histone_H2A_C protein degradation 16687393 1 9 13 -Kcnma1 KCNMA1 iso2 Channel, potassium; Endoplasmic reticulum; Membrane protein, integral; Membrane protein, multi-pass Q08460-2 16531 14|14 A3 mouse S899-p 469989 HGMLRQPsITTGVNI activity, induced 15280542 4 2 0 activation requires phosphorylation of the S899 site on each of the four subunits of the tetramer -CD6 CD6 Cell surface; Membrane protein, integral P30203 923 11q12.2 human S560-p 28095006 GPQYHPRsNSESSTS phosphorylation signaling pathway regulation 23711376 1 0 1 ERK1/2 phosphorylation, MAPK pathway activation -KCNK3 KCNK3 Channel, potassium; Membrane protein, integral; Membrane protein, multi-pass O14649 3777 2p23.3 human S393-p 2840504 GLMKRRSsV______ activity, induced; intracellular localization; activity, inhibited 21357689; 21838752 3 0 0 -Pak4 PAK4 EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, STE; Protein kinase, Ser/Thr (non-receptor) Q8BTW9 70584 7|7 B1 mouse S476-p 448023 KEVPRRKsLVGTPYW Pkinase phosphorylation; enzymatic activity, induced cell differentiation, inhibited; cell growth, induced; transcription, inhibited; signaling pathway regulation 34431242 13 66 140 induces phosphorylation of PPAR-gamma and regulates PI3K?Akt signalling -DAGLA NSDDR EC 3.1.1.-; Hydrolase; Membrane protein, integral; Membrane protein, multi-pass Q9Y4D2 747 11q12.2 human S808-p 27807806 RSIRGSPsLHAVLER enzymatic activity, inhibited 23502535 1 1 0 -TLR5 TLR5 Membrane protein, integral; Receptor, misc. O60602 7100 1q41 human Y798-p 473546 VVGSLSQyQLMKHQS TIR activity, induced transcription, induced 17157808; 25020193 2 1 0 -GCM1 GCM1 DNA-binding; Transcription factor Q9NP62 8521 6p12.1 human K367-ac 460587 AGNLYEEkVHVDFNS protein stabilization; ubiquitination transcription, induced 16166624 1 0 0 inhibits ubiquitination -Mcm3 MCM3 DNA replication; EC 3.6.4.12 P25206 17215 1|1 A4 mouse S112-p 2840507 SFGSKHVsPRTLTSC MCM_OB molecular association, regulation cell cycle regulation MCM2(INDUCES); MCM7(INDUCES); MCM5(INDUCES) DNA(INDUCES) 18524952 3 0 0 -HTR3A 5-HT(3) Channel, cation; Channel, ligand-gated; Membrane protein, integral; Membrane protein, multi-pass; Transporter, ion channel P46098 3359 11q23.2 human T369-p 28712602 TSQRPPAtSQATKTD Neur_chan_memb receptor desensitization, inhibited 23740249 1 0 0 -Nr1h3 LXR-alpha DNA-binding; Motility/polarity/chemotaxis; Nuclear receptor Q9Z0Y9 22259 2 E1|2 50.52 cM mouse T290-p 479433 DQIALLKtSAIEVML Hormone_recep molecular association, regulation; activity, inhibited transcription, inhibited; signaling pathway regulation SRC-1(DISRUPTS); N-CoR1(INDUCES); RXRA(DISRUPTS) 17296605 1 0 0 DNA Binding Activity of LXR/ RXR heterodimer was decreased. -Prkab1 AMPKB1 Autophagy; KINASE; Protein kinase, regulatory subunit P80386 83803 12q16 rat S108-p 448522 SKLPLTRsQNNFVAI AMPK1_CBM enzymatic activity, inhibited 11171104 11 64 2 -Foxo3 FOXO3A Autophagy; DNA-binding; Oncoprotein; Transcription factor Q9WVH4 56484 10 B2|10 22.79 cM mouse S317-p 453423 SRTNSNAsTVSGRLS intracellular localization cell cycle regulation; transcription, inhibited 12857750; 33530926 11 0 1 -NR1H3 LXR-alpha DNA-binding; Motility/polarity/chemotaxis; Nuclear receptor Q13133 10062 11p11.2 human S198-p 469114 SLPPRASsPPQILPQ protein conformation cell motility, inhibited; transcription, inhibited; transcription, altered 18250151; 25825525 6 0 0 CCR7, MARCKS, repression of pro-inflammatory genes; inhibits CCL24 expression -Espl1 separase EC 3.4.22.49; Protease P60330 105988 15|15 F3 mouse T1341-p 447675 EEEGPPCtPKPPGRA molecular association, regulation cytoskeletal reorganization 23857768 3 3 0 S1120 T1341 AA mutant -fewer cold-stable kinetochore-microtubule attachments and lacks tension -Tfap2a AP-2 alpha DNA-binding; Transcription factor P34056 21418 13 A3.3|13 20.01 cM mouse S258-p 5024712 GVLRRAKsKNGGRSL TF_AP-2 molecular association, regulation transcription, inhibited DNA(INDUCES) 21345437 2 0 0 induces adiponectin DNA binding thus controlling its transcription -Myl12b MRLC2 Contractile P18666 50685 9q38 rat S20-p 448595 KRPQRATsNVFAMFD activity, induced; intracellular localization; protein conformation exocytosis, altered 18283106; 24414065; 9425160 62 64 295 -GTF2I GTF2I iso2 DNA-binding; Transcription, coactivator/corepressor P78347-2 2969 7q11.23 human S371-p 457074 GIPFRRPsTYGIPRL GTF2I molecular association, regulation transcription, altered SMAD3(INDUCES) 16055503 2 11 139 -Pln PLB Inhibitor; Membrane protein, integral P61016 64672 20q11 rat S16-p 448114 RSAIRRAsTIEMPQQ Phospholamban activity, induced; enzymatic activity, induced 21447388; 33624728; 33798601 78 15 66 induces SERCA activity; induced SERCA2a activity; induce calcium uptake -MISP MISP Unknown function Q8IVT2 126353 19p13.3 human S541-p 3205368 PALRLQKsQSSDLLE AKAP2_C molecular association, regulation ACTA1(DISRUPTS) 34023777 1 13 19 -FOXP3 FOXP3 C2H2-type zinc finger protein; Cell cycle regulation; DNA-binding; Transcription factor Q9BZS1 50943 Xp11.23 human S422-p 35517300 KKRSQRPsRCSNPTP molecular association, regulation transcription, inhibited DNA(DISRUPTS) 25096571 1 0 0 -PRKCE PKCE EC 2.7.11.13; KINASE; Kinase, protein; Protein kinase, AGC; Protein kinase, Ser/Thr (non-receptor) Q02156 5581 2p21 human T566-p 448787 LNGVTTTtFCGTPDY Pkinase molecular association, regulation; intracellular localization; enzymatic activity, induced cell growth, induced AKAP9(DISRUPTS) 10945988; 11964154; 21806543 6 2 0 -SCN5A SCN5A Channel, sodium; Membrane protein, integral; Membrane protein, multi-pass Q14524 6331 3p22.2 human S664-p 27281501 GARQRALsAVSVLTS Na_trans_cytopl activity, induced; protein conformation 33410863 4 6 0 -FGF2 FGF2 Activator; Motility/polarity/chemotaxis P09038 2247 4q28.1 human S250-p 3146601 NNYNTYRsRKYTSWY FGF molecular association, regulation cell differentiation, altered; cell growth, altered CK2B(INDUCES) 10657989 1 0 0 -Dppa2 DPPA2 Cancer Testis Antigen (CTA) Q9CWH0 73703 16|16 B5 mouse K31-sm 1877126901 ILTLVPFkEEEEPNT sumoylation transcription, inhibited 31226106; 32937131 2 2 0 -FGFR4 FGFR4 EC 2.7.10.1; KINASE; Kinase, protein; Membrane protein, integral; Protein kinase, TK; Protein kinase, tyrosine (receptor) P22455 2264 5q35.2 human Y390-p 52421900 LLLLAGLyRGQALHG TM molecular association, regulation STAT3(INDUCES) 26675719 1 1 0 -Th TH Amino Acid Metabolism - tyrosine; EC 1.14.16.2; Endoplasmic reticulum; Mitochondrial; Oxidoreductase; Vesicle P24529 21823 7 F5|7 88.06 cM mouse S31-p 448544 KQAEAVTsPRFIGRR TOH_N protein stabilization; enzymatic activity, induced neural plasticity 15471880; 32358047 43 8 0 IRL790-induced neurotransmission -Ulk1 ULK1 Autophagy; EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, Other; Protein kinase, Ser/Thr (non-receptor) O70405 22241 5|5 F mouse S757-p 483139 PVVFTVGsPPSGATP molecular association, regulation; enzymatic activity, inhibited autophagy, induced; autophagy, inhibited; transcription, altered ATG13(DISRUPTS); AMPKA1(DISRUPTS) 21258367; 25361081; 29196462; 32912901; 33528041; 34695513; 34749750; 35805144; 36099296 78 15 2 -Camk2a CAMK2A EC 2.7.11.17; KINASE; Kinase, protein; Protein kinase, CAMK; Protein kinase, Ser/Thr (non-receptor) P11275 25400 18q12.1 rat T286-p 447797 SCMHRQEtVDCLKKF molecular association, regulation; intracellular localization; protein conformation; phosphorylation; enzymatic activity, induced neural plasticity; cell growth, induced; cytoskeletal reorganization; signaling pathway regulation DRD3(INDUCES); RPT6(INDUCES); NMDAR2A(INDUCES); CAMK2A(INDUCES); NMDAR2B(INDUCES); CAMK2B(INDUCES); SYN1(INDUCES); Calmodulin(INDUCES); CAMK2A(DISRUPTS); MARCKS(INDUCES) 15383398; 15447676; 15788767; 16049173; 16095822; 17144902; 17156196; 17559813; 19217379; 20178748; 20660727; 21059908; 23467346; 23490331; 24407174; 9681448; 9774470 155 34 72 -WTAP WTAP Nucleolus; Spliceosome Q15007 9589 6q25.3 human S341-p 3196721 AGYESVDsPTGSENS protein stabilization carcinogenesis, induced; cell differentiation, induced 33217317; 34312368 2 6 0 -FOXA1 FOXA1 DNA-binding; Transcription factor P55317 3169 14q21.1 human K270-ac 11263049 QKRFKCEkQPGAGGG molecular association, regulation chromatin organization, altered DNA(DISRUPTS) 19897491 1 0 0 -GJA1 GJA1 Channel, misc.; Membrane protein, integral; Membrane protein, multi-pass; Motility/polarity/chemotaxis P17302 2697 6q22.31 human Y265-p 447815 KDCGSQKyAYFNGCS molecular association, regulation; intracellular localization; protein processing; activity, inhibited; protein conformation; phosphorylation signaling pathway regulation Src(INDUCES); ZO1(INDUCES); DBN1(DISRUPTS) 11035005; 23828237; 26033246; 30448479 26 3 11 inhibits pregnancy-adapted Ca2+ response; induces phosphorylation of Y313 and Y247 -RBL1 Rb-like 1 Transcription, coactivator/corepressor; Tumor suppressor P28749 5933 20q11.23 human T997-p 3903587 HKNGSGLtPRSALLY Rb_C molecular association, regulation E2F1(DISRUPTS) 28439018 1 4 16 -PRMT5 PRMT5 Cell cycle regulation; EC 2.1.1.125; METHYLTRANSFERASE; Methyltransferase; Methyltransferase, protein arginine; RNA processing O14744 10419 14q11.2 human S335-p 1869601001 EKDPIKYsQYQQAIY PRMT5 molecular association, regulation; methylation; intracellular localization; enzymatic activity, induced cell growth, induced; apoptosis, inhibited; signaling pathway regulation NDRG2(INDUCES) 31765670 1 1 0 -CIITA CIITA DNA-binding; EC 2.7.11.1; KINASE; Protein kinase, Ser/Thr (non-receptor); Transcription, coactivator/corepressor P33076 4261 16p13.13 human S1050-p 448442 AASLLRLsLYNNCIC LRR_6 transcription, altered 11416140 1 0 0 -CEP76 CEP76 Q8TAP6 79959 18p11.21 human K279-ac 14320646 ERQKTAEkERLFLVY activity, inhibited; phosphorylation 27065328 1 2 0 acetylation at K279 limits protein activity and S83 phosphorylation -Per2 PER2 Nuclear receptor co-regulator; Nucleolus; Transcription factor O54943 18627 1|1 D mouse S53-p 9439800 TGRDSQGsDCDDNGK protein degradation transcription, altered 19491384 1 0 0 ; S53A mutant of Per2 impairs circadian gene expression -Pax6 PAX6 DNA-binding; Motility/polarity/chemotaxis; Transcription factor P63015 18508 2 E3|2 55.31 cM mouse T373-p 458810 GRSYDTYtPPHMQTH transcription, induced 16407227 1 0 1 -Mef2d MEF2D DNA-binding; Transcription factor O89038 81518 2q34 rat S430-p 449407 SIKSEPVsPSRERSP protein degradation apoptosis, induced 12691662; 25417143 7 19 26 -Rem1 REM1 G protein; G protein, monomeric; G protein, monomeric, RGK O35929 19700 2|2 H1 mouse S288-p 1211203 RRALKARsKSCHNLA molecular association, regulation; intracellular localization 14-3-3 beta(DISRUPTS) 17605760 1 0 0 -RELA NFkB-p65 DNA-binding; Nuclear receptor co-regulator; Transcription factor Q04206 5970 11q13.1 human K315-ub 25087013 TFKSIMKkSPFSGPT transcription, inhibited 21706061 1 2 0 inhibits acetylation -Kcnma1 KCNMA1 iso5 Channel, potassium; Endoplasmic reticulum; Membrane protein, integral; Membrane protein, multi-pass Q08460-5 16531 14|14 A3 mouse S873-p 469989 HGMLRQPsITTGVNI activity, induced 23407708 4 2 0 regulates NO/cGMP signaling -EIF4ENIF1 4E-T Karyopherin; Nuclear import; Translation Q9NRA8 56478 22q12.2 human S513-p 3213594 NLESHLMsPAEIPGQ EIF4E-T molecular association, regulation 4E-T(INDUCES) 22966201 1 10 2 required for processing bodies (PBs or P bodies) assembly -Becn1 beclin 1 Adaptor/scaffold; Autophagy; Membrane protein, peripheral O88597 56208 11|11 D mouse S91-p 5473540 ARMMSTEsANSFTLI autophagy, induced 33779513 14 2 1 -MAPT Tau iso8 ACETYLTRANSFERASE; Acetyltransferase; Cytoskeletal P10636-8 4137 17q21.31 human K163-ac 56833100 GAAPPGQkGQANATR phosphorylation 28855586 2 0 0 inhibts Tau iso8 phosphorylation and microtubule binding, ameliorates amyloid-beta toxicity -RGS4 RGS4 GAP; GAP, RGS Q0R4E4 100009014 rabbit S103-p 31033000 EEYKKIKsPSKLSPK RGS molecular association, regulation G-alpha(q)(INDUCES) 24407588 1 1 0 -RUNX1/RUNX1T1 fusion AML1-ETO A0A7S8LV65 human K58-m1 1880752700 AGAALAGkLRSGDRS carcinogenesis, induced; cell growth, induced; transcription, inhibited 31699991 1 1 0 essential for leukemic cell expansion -Npr2 ANPB EC 4.6.1.2; Guanylyl cyclase; KINASE; Kinase, protein; Lyase; Membrane protein, integral; Nucleotide Metabolism - purine; Protein kinase, RGC; Protein kinase, dual-specificity (receptor); Receptor, misc. P16067 116564 5q22 rat S523-p 447761 TLSLRGSsYGSLMTA PK_Tyr_Ser-Thr activity, induced 9624142 3 3 0 -XPC XPC DNA repair, damage Q01831 7508 3p25.1 human K655-sm 2798303 ALKRHLLkYEAIYPE BHD_1 protein degradation DNA repair, induced 17693435 1 0 0 -NUB1 NYREN18 Ubiquitin conjugating system Q9Y5A7 51667 7q36.1 human K159-ub 12288848 KAMVLELkQSEEDAR Ubiquitin_5 neddylation 28099510 1 3 1 inhibits neddylation, modulates NYREN18 K159 ubiquitination -Net1 NET1 GEF; GEF, Rac/Rho; Motility/polarity/chemotaxis; Oncoprotein A0A8I6AVA8 307098 10p15.1 rat S106-p 3204291 TSLANLIsPVRNGAV intracellular localization cell motility, induced; cytoskeletal reorganization 29361525 2 11 0 relocalization to cytosol; increase in invadopodia number and degradation area -Jak2 JAK2 EC 2.7.10.2; KINASE; Kinase, protein; Oncoprotein; Protein kinase, TK; Protein kinase, tyrosine (non-receptor) Q62120 16452 19 C1|19 23.73 cM mouse Y972-p 470145 EYLGTKRyIHRDLAT PK_Tyr_Ser-Thr protein conformation; phosphorylation; enzymatic activity, induced 18636744; 20304997 3 1 0 -ITGB4 ITGB4 iso2 Cell adhesion; Membrane protein, integral; Motility/polarity/chemotaxis; Receptor, misc. P16144-2 3691 17q25.1 human Y1422-p 450140 SSTLTRDyNSLTRSE molecular association, regulation cell adhesion, altered PLCG1(INDUCES); SHC1(INDUCES) 11044453; 33883672 3 0 72 -FBP1 FBPase Carbohydrate Metabolism - fructose and mannose; Carbohydrate Metabolism - glycolysis and gluconeogenesis; Carbohydrate Metabolism - pentose phosphate pathway; EC 3.1.3.11; Mitochondrial; Phosphatase (non-protein) P09467 2203 9q22.32 human S88-p 55578725 LVMNMLKsSFATCVL FBPase enzymatic activity, inhibited 27153534 1 1 0 -PTH1R PTHR GPCR, family 2; Membrane protein, integral; Membrane protein, multi-pass; Receptor, GPCR Q03431 5745 3p21.31 human S504-p 2853101 GPMVSHTsVTNVGPR receptor internalization, induced; molecular association, regulation ARR3(INDUCES) 27623777 3 1 0 S503 AND T504 IN THE SECOND CLUSTER ARE RESPONSIBLE FOR 70% OF ARRESTIN3 RECRUITMENT -Irf3 IRF3 DNA-binding; Transcription factor P70671 54131 7|7 B3 mouse K359-ac 1880015200 VKRLVMVkVVPTCLK intracellular localization transcription, inhibited 30842237 1 1 0 KAT8 impaired recruitment of IRF3 to Ifn gene promoters -CCNE2 CCNE2 Activator; Cell cycle regulation O96020 9134 8q22.1 human T392-p 452067 VCNGGIMtPPKSTEK protein degradation; ubiquitination 19084516; 9840943 2 8 6 -LMO7 LMO7 iso3 Adaptor/scaffold Q8WWI1-3 4008 13q22.2 human S417-p 4687531 KWKDRRKsYTSDLQK DUF4757 molecular association, regulation; phosphorylation carcinogenesis, inhibited; cell growth, inhibited; transcription, induced; signaling pathway regulation STING(INDUCES) 33767426 2 16 14 binding to STING induces STING-TBK1 binding and TBK1 autophosphorylation, regulates STING?IFN-? pathway -Sqstm1 SQSTM1 Autophagy; Nuclear receptor co-regulator; Ubiquitin conjugating system O08623 113894 10q22 rat S402-p 22264800 ESLSQMLsMGFSDEG UBA_5 molecular association, regulation autophagy, induced; autophagy, altered LRRK2(INDUCES) 27631370; 34026282 30 7 0 -PIK3R2 PIK3R2 Kinase, lipid; Motility/polarity/chemotaxis O00459 5296 19p13.11 human Y464-p 449572 SREYDQLyEEYTRTS PI3K_P85_iSH2 activity, induced; molecular association, regulation; intracellular localization; phosphorylation cell cycle regulation; carcinogenesis, induced; carcinogenesis, inhibited; cell growth, induced; cell motility, induced; transcription, altered; signaling pathway regulation KPNA1(INDUCES) 24634221; 26411363; 34380633; 34785213; 36857183 10 55 1664 -Pacsin2 PACSIN2 Adaptor/scaffold; Motility/polarity/chemotaxis Q9WVE8 23970 15|15 E1 mouse S313-p 4786393 ADLNRTLsRREKKKA intracellular localization 26092940 3 7 20 membrane binding affinity and tubulation decreased -Trhr TRHR GPCR, family 1; Membrane protein, integral; Membrane protein, multi-pass; Receptor, GPCR Q01717 25570 7q31 rat S364-p 1229700 IKESDRFsTELDDIT receptor internalization, altered 17989235; 20345371 3 0 0 -Gpm6a GPM6A Cell surface; Channel, calcium; Membrane protein, integral; Membrane protein, multi-pass Q812E9 306439 16p11 rat T10-p 11488702 ENMEEGQtQKGCFEC activity, induced 12359212 1 0 0 -KIT Kit EC 2.7.10.1; KINASE; Kinase, protein; Membrane protein, integral; Oncoprotein; Protein kinase, TK; Protein kinase, tyrosine (receptor) P10721 3815 4q12 human Y553-p 13876401 KYLQKPMyEVQWKVV enzymatic activity, induced 20147452 1 1 0 -CDCP1 CDCP1 Cell surface; Membrane protein, integral Q9H5V8 64866 3p21.31 human Y806-p 454988 PESESEPyTFSHPNN carcinogenesis, induced; cell growth, induced 25728678 2 6 93 Tyr734 is a key precursor phosphorylation event allowing Tyr707 and Tyr806 phosphorylation -LZTS2 LZTS2 Nuclear export Q9BRK4 84445 10q24.31 human S224-p 1871717502 LSDSGRNsLSSLPTY protein degradation; molecular association, regulation; ubiquitination; phosphorylation carcinogenesis, induced; cell motility, induced; cell growth, induced; signaling pathway regulation BTRC(INDUCES) 33420362 1 0 0 induces phosphorylation of downstream targets thus inducing the PI3K/AKT signaling pathway -UHRF1 UHRF1 iso2 DNA-binding; EC 6.3.2.-; EC 6.3.2.19; Ligase; Transcription factor; UBIQUITIN LIGASE; Ubiquitin conjugating system; Ubiquitin ligase Q96T88-2 29128 19p13.3 human S311-p 2902206 DNPMRRKsGPSCKHC protein degradation 28394343 3 1 0 -Gab2 GAB2 Adaptor/scaffold Q9Z1S8 14389 7|7 E1 mouse T388-p 448383 ATIPRRNtLPAMDNS signaling pathway regulation 26060331 2 23 54 enhances insulin-induced Akt signaling; suppresses EGF-induced Akt signaling -Cdk8 CDK8 Cell cycle regulation; EC 2.7.11.22; EC 2.7.11.23; KINASE; Kinase, protein; Protein kinase, CMGC; Protein kinase, Ser/Thr (non-receptor) Q8R3L8 264064 5|5 G3 mouse S62-p 1876860402 EGTGISMsACREIAL Pkinase phosphorylation cell growth, inhibited; transcription, induced 35394840 1 1 0 -YAP1 YAP1 Oncoprotein; Transcription, coactivator/corepressor P46937 10413 11q22.1 human S397-p 3190672 TYHSRDEsTDSGLSM protein degradation; ubiquitination; intracellular localization cell differentiation, inhibited; carcinogenesis, induced; carcinogenesis, inhibited; cell growth, inhibited; apoptosis, induced; transcription, induced; cell growth, induced; cell motility, altered; transcription, inhibited 24658687; 26039999; 27593935; 31239271; 33536280; 34052254 32 13 5 -CHN2 ARHGAP3 GAP; GAP, Rac/Rho P52757 1124 7p14.3 human Y21-p 482808 VSSDAEEyQPPIWKS activity, inhibited cell motility, altered 17560670 1 0 0 negatively controls Rac-GAP activity -XRCC5 Ku80 DNA-binding; EC 3.6.1.-; EC 3.6.4.-; Helicase; Nuclear receptor co-regulator; Nucleolus; RNA-binding P13010 7520 2q35 human K439-ub 15391484 QYMFSSLkNSKKYAP Ku molecular association, regulation DNA repair, induced DNA(DISRUPTS) 27895153 1 2 1 -Pip4p1 TMEM55B EC 3.1.3.78; Hydrolase; Membrane protein, integral; Membrane protein, multi-pass Q3TWL2 219024 14|14 C1 mouse S169-p 3204510 PVHPGPLsPEPQPMG Tmemb_55A intracellular localization 31329883 1 27 13 -MAML1 MAML1 Transcription, coactivator/corepressor Q92585 9794 5q35.3 human K299-sm 13310801 LAQDINIkTEFSPAA molecular association, regulation transcription, inhibited HDAC7(INDUCES) 20203086 1 1 0 -SUFU SUFU Adaptor/scaffold; Transcription, coactivator/corepressor; Tumor suppressor Q9UMX1 51684 10q24.32 human S342-p 4786843 LAHDRAPsRKDSLES SUFU_C molecular association, regulation; protein stabilization; intracellular localization FBXL17(DISRUPTS) 21317289; 27234298 4 13 0 -Agtr1 AT1 GPCR, family 1; Membrane protein, integral; Membrane protein, multi-pass; Receptor, GPCR P25095 24180 17p12 rat S331-p 452091 AKSHSSLsTKMSTLS activity, induced 16831865 2 1 0 -KLF11 TIEG2 C2H2-type zinc finger protein; DNA-binding; Transcription factor O14901 8462 2p25.1 human S124-p 456010 PSTRTPVsPQVTDSK molecular association, regulation SIN3A(DISRUPTS) 12006497 1 5 22 -Npas4 NPAS4 DNA-binding Q8BGD7 225872 19|19 A mouse S580-p 1871095702 KLPPSPSsPGNGDCT molecular association, regulation neural plasticity; transcription, induced CBP(INDUCES) 31801086 1 1 0 -TH TH iso2 Amino Acid Metabolism - tyrosine; EC 1.14.16.2; Endoplasmic reticulum; Mitochondrial; Oxidoreductase; Vesicle P07101-2 7054 11p15.5 human S58-p 448544 SYTPTPRsPRFIGRR TOH_N enzymatic activity, induced 7901013 43 8 0 -NR3C2 MCR DNA-binding; Nuclear receptor P08235 4306 4q31.23 human S843-p 29669801 NEEKMHQsAMYELCQ Hormone_recep intracellular localization transcription, induced; transcription, inhibited 24206662; 30021155 3 2 0 pendrin expression; nuclear (WT and S843A) vs cytoplasmic (S843E) localization -Mybl2 B-Myb DNA-binding; Motility/polarity/chemotaxis; Transcription factor P48972 17865 2 H2|2 84.0 cM mouse T524-p 450112 DNTPHTPtPFKNALE Cmyb_C activity, induced transcription, induced 10095772 3 1 9 -BMI1 BMI1 EC 6.3.2.-; Ligase; Motility/polarity/chemotaxis; Oncoprotein; UBIQUITIN LIGASE; Ubiquitin conjugating system; Ubiquitin ligase P35226 648 10p12.2 human S110-p 56654163 SADAANGsNEDRGEV protein degradation cell growth, induced 28270146 1 2 0 -Hck Hck EC 2.7.10.2; KINASE; Kinase, protein; Oncoprotein; Protein kinase, TK; Protein kinase, tyrosine (non-receptor) P08103 15162 2 H1|2 75.41 cM mouse Y520-p 448322 YTATESQyQQQP___ enzymatic activity, inhibited 10934191 3 8 326 Y519 phosphorylation keeps the kinase in an inactive state and does not permit autophosphorylation at Y49 and Y408. -LDB1 LDB1 iso2 Transcription, coactivator/corepressor Q86U70-2 8861 10q24.32 human K134-ub 14512104 SMVTQHGkPMFTQVC LIM_bind protein degradation 32229578 2 0 0 -YBX1 YB-1 RNA processing; RNA splicing; RNA-binding; Transcription factor P67809 4904 1p34.2 human Y281-p 29656300 QQPPQRRyRRNFNYR intracellular localization 24103640 1 0 0 Y281 phosphorylation nuclear localization, unphosphorylated cytoplasmic localization -Eif4ebp1 4E-BP1 Translation; Translation initiation Q60876 13685 8 A2|8 15.95 cM mouse S64-p 447527 FLMECRNsPVAKTPP eIF_4EBP transcription, induced; translation, induced 34664403; 34704268 104 60 6 -Rasgrp2 RASGRP2 GEF; GEF, Ras Q9QUG9 19395 19|19 A mouse S117-p 468585 EGNRRHSsLIDIESV activity, induced; molecular association, regulation 14-3-3 beta(INDUCES) 26804993 2 14 12 -TPD52 TPD52 Calcium-binding; Endoplasmic reticulum P55327 7163 8q21.13 human S176-p 465974 KNSPTFKsFEEKVEN TPD52 activity, induced; molecular association, regulation; intracellular localization cell cycle regulation; exocytosis, induced LAMP1(INDUCES) 20032513; 20946871; 23868405 4 56 31 -TGFBR1 TGFBR1 EC 2.7.11.30; KINASE; Kinase, protein; Membrane protein, integral; Protein kinase, Ser/Thr (receptor); Protein kinase, TKL; Receptor, misc. P36897 7046 9q22.33 human T176-p 4331007 PFISEGTtLKDLIYD TGF_beta_GS cell growth, altered 8576253 1 0 0 -Tsc2 TSC2 Cell cycle regulation; GAP; GAP, misc.; Nuclear receptor co-regulator; Tumor suppressor P49816 24855 10q12 rat S1385-p 450216 FQPSQPLsKSSSSPE activity, inhibited; phosphorylation translation, altered; apoptosis, inhibited 16959574 2 1 1 inhibits mTOR signaling. required for Wnt-3a to stimulation phosphorylation of S6K and 4EBP1 and increase protein levels of cyclin D1 and VEGF (cyclin D1 through translation not transcription). -Kif21a KIF21A Microtubule-binding; Motor Q9QXL2 16564 15 E3|15 45.86 cM mouse T1159-p 487343 KNKARRRtTTQMELL molecular association, regulation ANKRD15(DISRUPTS) 29158259 1 1 10 -Nsmf NSMF Adaptor/scaffold Q9EPI6 117536 3p13 rat S180-p 27713502 AKLVPGPsPRAFGLE activity, induced; molecular association, regulation; intracellular localization; phosphorylation apoptosis, inhibited; transcription, induced LMO4(DISRUPTS) 23452857; 27559307; 36594364 3 1 0 -PRKCA PKCA EC 2.7.11.13; KINASE; Kinase, protein; Oncoprotein; Protein kinase, AGC; Protein kinase, Ser/Thr (non-receptor) P17252 5578 17q24.2 human T638-p 448685 TRGQPVLtPPDQLVI Pkinase_C molecular association, regulation; intracellular localization; phosphorylation; enzymatic activity, induced cell cycle regulation CD82(INDUCES) 17504762; 17942932 22 15 2 phosphorylation of PKCA induces phosphorylation of EGFR; Requires dual phosphorylation to locate to pericentrion. -Srpk2 SRPK2 EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, CMGC; Protein kinase, Ser/Thr (non-receptor) NP_001100045 296753 4q11 rat T485-p 483237 PSRDRSRtVSASSTG apoptosis, altered 19592491 3 6 0 -PAPOLA PAP-alpha EC 2.7.7.19; RNA processing; RNA splicing; Transferase P51003 10914 14q32.2 human K444-sm 2586344 WVIGLVFkKTENSEN protein stabilization; enzymatic activity, inhibited 18281463 1 0 0 -KLF13 KLF13 C2H2-type zinc finger protein; DNA-binding Q9Y2Y9 51621 15q13.3 human S119-p 40721820 GAAAAPPsPAWSEPE protein degradation; ubiquitination 37029927 1 1 0 -FAF1 FAF1 Apoptosis; Nuclear receptor co-regulator Q9UNN5 11124 1p32.3 human S289-p 450286 ITDVHMVsDSDGDDF intracellular localization cell cycle regulation 12832043; 18790738; 27662363 3 2 0 mediates the proteasome-dependent degradation of AurA; nuclear localization; induces G2/M arrest -SLC9A1 NHE1 Membrane protein, integral; Membrane protein, multi-pass; Motility/polarity/chemotaxis; Transporter; Transporter, SLC family P19634 6548 1p36.11 human S703-p 448347 MSRARIGsDPLAYEP activity, induced cell growth, induced; cell motility, induced; cytoskeletal reorganization; transcription, altered; cell growth, altered 10400637; 25578862; 27049728 9 73 199 stress fiber formation, in S703A and T653A mutants proliferation was substantially higher; migration, invasion, spheroid growth, anchorage-dependent and soft agar colony formation -Vim Vimentin Cytoskeletal; Motility/polarity/chemotaxis P20152 22352 2 A1|2 10.04 cM mouse S73-p 449025 SAVRLRSsVPGVRLL Filament_head intracellular localization cytoskeletal reorganization 12458200; 35656400 14 53 32 -Hrh1 H1R GPCR, family 1; Membrane protein, integral; Membrane protein, multi-pass; Receptor, GPCR P70174 15465 6 E3|6 53.05 cM mouse S399-p 450937 WKRLRSHsRQYVSGL 7tm_1 receptor desensitization, induced; activity, inhibited 24709960 4 0 0 greater Mn2+ influx, reduced production of intracellular DAG -PRDX2 PRDX2 EC 1.11.1.15; Oxidoreductase P32119 7001 19p13.13 human Y193-p 448985 NVDDSKEyFSKHN__ 1-cysPrx_C intracellular localization; protein conformation; enzymatic activity, induced 33535382 1 8 119 -EGFR EGFR EC 2.7.10.1; KINASE; Kinase, protein; Membrane protein, integral; Oncoprotein; Protein kinase, TK; Protein kinase, tyrosine (receptor) P00533 1956 7p11.2 human S229-p 18944906 RCRGKSPsDCCHNQC Furin-like intracellular localization transcription, induced 21487020 1 1 0 develop gefitinib resistance; regulates expression of BCRP/ABCG2 -KNL1 CASC5 iso2 Cancer Testis Antigen (CTA); Cell cycle regulation Q8NG31-2 57082 15q15.1 human T875-p 40560200 DKNDMDItKSYTIEI MELT molecular association, regulation; intracellular localization cell cycle regulation BUB3(INDUCES) 24363448; 26119734 2 0 0 induces localization of BUB1 and BUBR1 ; recruitment of SAC proteins -Cd79a Ig-alpha Immunoglobulin superfamily; Membrane protein, integral P11911 12518 7 A3|7 13.49 cM mouse Y182-p 473649 DYEDENLyEGLNLDD ITAM activity, induced; molecular association, regulation; phosphorylation cell differentiation, altered; signaling pathway regulation Syk(INDUCES) 11859098; 11909947; 17163454; 9531288 8 1 13 Ca(2+) signaling -Ptk2 FAK EC 2.7.10.2; KINASE; Kinase, protein; Protein kinase, TK; Protein kinase, tyrosine (non-receptor) P34152 14083 15 D3|15 33.94 cM mouse Y576-p 447889 RYMEDSTyYKASKGK PK_Tyr_Ser-Thr activity, induced; molecular association, regulation carcinogenesis, induced; cell growth, induced; cell adhesion, altered; transcription, altered; signaling pathway regulation P130Cas(INDUCES) 10672902; 36209205; 7529876; 9038154 95 65 2523 -TBC1D3 TBC1D3 GAP; GAP, Rab; Oncoprotein Q8IZP1 729873 17q12 human Y163-p 64210900 HIFFRDRyGTKQREL RabGAP-TBC molecular association, regulation Calmodulin(NOT_REPORTED) 28422741 1 0 0 -BCL10 Bcl-10 Apoptosis; Transcription, coactivator/corepressor; Tumor suppressor O95999 8915 1p22.3 human K63-ub 2134712 SCRTSSRkRAGKLLD CARD activity, induced; protein degradation; molecular association, regulation; intracellular localization carcinogenesis, induced; transcription, induced; signaling pathway regulation IKKG(INDUCES) 18287044; 27070702; 27777308 3 0 0 promote NF-kB activation, cIAP1/2-mediated polyubiquitination is necessary for the recruitment of LUBAC to the CBM complex; TCR-mediated NF-?B activation -STK38 NDR1 EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, AGC; Protein kinase, Ser/Thr (non-receptor) Q15208 11329 6p21.31 human T407-p 41425401 EIKSIDDtSNFDEFP Pkinase_C molecular association, regulation; intracellular localization; enzymatic activity, inhibited; protein conformation cell cycle regulation; cytoskeletal reorganization MOB1A(DISRUPTS); HCCA2(INDUCES) 26057687 1 0 0 regulation of spindle orientation, cortical localization of LGN-NuMA -DNM1L DRP1 Apoptosis; EC 3.6.5.5; Endoplasmic reticulum; Hydrolase; Microtubule-binding; Mitochondrial; Motor O00429 10059 12p11.21 human S40-p 31872528 TQSSGKSsVLESLVG Dynamin_N intracellular localization; enzymatic activity, induced apoptosis, induced 25192600 2 1 0 mitochondrial localization, increased GTPase activity, mitochondrial fragmentation -Sod2 SOD2 EC 1.15.1.1; Mitochondrial; Oxidoreductase P09671 20656 17 A1|17 8.75 cM mouse K114-ac 480880 PKGGGEPkGELLEAI Sod_Fe_C enzymatic activity, altered 28433661 0 5 8 -STT3A Chk1 EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, CAMK; Protein kinase, Ser/Thr (non-receptor); Tumor suppressor Q8AYC9 374260 chicken S286-p 465527 SSGGVTEsPGALPKH enzymatic activity, induced cell cycle regulation 21765472 5 12 14 -MITF MITF iso9 DNA-binding; Oncoprotein; Transcription factor O75030-9 4286 3p13 human S73-p 450264 PGSSAPNsPMAMLTL MITF_TFEB_C_3_N activity, induced; protein degradation; ubiquitination cell cycle regulation; transcription, induced; transcription, altered 10673502; 16162175; 20701798; 21749389 16 1 0 enhances cell survival -GFAP GFAP Cytoskeletal P14136 2670 17q21.31 human S38-p 449621 LGPGTRLsLARMPPP Filament_head protein stabilization 12177195 6 3 0 -Gorasp1 GRASP65 Vesicle O35254 56082 8q32 rat S376-p 467957 FEISFPDsPGSQAQV intracellular localization cell cycle regulation 23259055 1 13 9 Regulation of mitotic golgi disassembly and reassembly; inactivation of T220/T224, and eventually S277partial dephosphorylation -CD163L1 CD163L1 Membrane protein, integral; Receptor, misc. P30205 338056 cow Y1326-p 470034 DALAEAVyEELDYLL intracellular localization endocytosis, altered 16997376; 19130552 3 0 0 -IGF2BP1 IGF2BP1 RNA-binding; Translation Q9NZI8 10642 17q21.32 human K190-ub 15390840 VAAGAPAkQQQVDIP carcinogenesis, induced; cell growth, induced 34779401 1 5 9 hepatocarcinogenesis -SMAD3 SMAD3 DNA-binding; Nuclear receptor co-regulator; Transcription factor P84022 4088 15q22.33 human K53-m3 1883845003 GQLDELEkAITTQNV activity, induced; intracellular localization carcinogenesis, induced; cell motility, induced 35085106 1 1 0 targeting SMAD3 K53/K333 methylation inhibits cancer metastasis; membrane localization; promotes migration and invasion -CIB1 CIB1 Cell adhesion; Motility/polarity/chemotaxis Q99828 10519 15q26.1 human K65-ub 15386514 ILSLPELkANPFKER protein degradation cell motility, inhibited 33082516 1 6 3 -CDC20 CDC20 Cell cycle regulation; Ubiquitin conjugating system Q12834 991 1p34.2 human S170-p 23092094 KTCRYIPsLPDRILD protein degradation; molecular association, regulation; ubiquitination CDC27(INDUCES); CDH1(INDUCES) 23643811 1 0 1 -SHC1 SHC1 Adaptor/scaffold; Apoptosis; Mitochondrial; Motility/polarity/chemotaxis P29353 6464 1q21.3 human S54-p 457345 PPLPGDDsPTTLCSF protein stabilization apoptosis, induced 16251354 1 0 0 Phosphorylation necessary to promote activated-Rac1-induced oxidative stress (ROS-induced apoptosis). -Rps6ka3 RSK2 EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, AGC; Protein kinase, Ser/Thr (non-receptor) P18654 110651 X F4|X 73.27 cM mouse S369-p 448064 TAKTPKDsPGIPPSA Pkinase_C enzymatic activity, induced 10480933; 10856237 10 51 20 -Shc1 SHC1 Adaptor/scaffold; Apoptosis; Mitochondrial; Motility/polarity/chemotaxis P98083 20416 3 F1|3 39.11 cM mouse Y349-p 448509 EEPPDHQyYNDFPGK activity, induced; molecular association, regulation; phosphorylation cell differentiation, altered; cell growth, induced GRB2(INDUCES) 11713219; 12101399; 14576154; 15930121; 24837366 32 22 947 Shc3F breast tumor growth was significantly delayed, and display a significant increase in VEGF protein -Nfatc2 NFAT1 DNA-binding; Transcription factor Q60591 18019 2 H3|2 88.91 cM mouse S53-p 455325 PIAHKAIsSPSGLAY transcription, induced 11030334 0 7 2 -RET Ret EC 2.7.10.1; KINASE; Kinase, protein; Membrane protein, integral; Oncoprotein; Protein kinase, TK; Protein kinase, tyrosine (receptor) P07949 5979 10q11.21 human Y952-p 447628 VTLGGNPyPGIPPER PK_Tyr_Ser-Thr enzymatic activity, induced cell growth, altered 11956105; 8637703 2 0 0 -Csnk1d CK1D EC 2.7.11.1; EC 2.7.11.26; KINASE; Kinase, protein; Protein kinase, CK1; Protein kinase, Ser/Thr (non-receptor) Q06486 64462 10q32.3 rat S370-p 483997 MERERKVsMRLHRGA intracellular localization; enzymatic activity, inhibited 17594292; 23861943; 26803658 3 1 0 -TOP2A TOP2A EC 5.99.1.3; Isomerase P11388 7153 17q21.2 human T1343-p 448763 FSDFDEKtDDEDFVP intracellular localization 11699638 4 13 9 -MYLK smMLCK EC 2.7.11.18; KINASE; Kinase, protein; Protein kinase, CAMK; Protein kinase, Ser/Thr (non-receptor) P11799 396445 chicken S140-p 41411900 KTPGGRLsVPPVEHR molecular association, regulation ACTB(DISRUPTS) 26567572 2 1 0 in vitro the single S149D mutation reduced N27-157 association with F-actin -Oprk1 KOR-1 GPCR, family 1; Membrane protein, integral; Membrane protein, multi-pass; Receptor, GPCR P34975 29335 5q12 rat Y157-p 3082309 TMMSVDRyIAVCHPV 7tm_1 activity, induced 10995763 1 0 0 potentiation for KIR3 activation -USP2 USP2 DEUBIQUITINASE; EC 3.4.19.12; Protease; Ubiquitin-specific protease O75604 9099 11q23.3 human S2-p 1880716202 ______MsQLSSTLK molecular association, regulation DNA repair, induced RECQL4(INDUCES) DNA(INDUCES) 36436562 1 0 0 -BSG BSG iso2 Immunoglobulin superfamily; Membrane protein, integral P35613-2 682 19p13.3 human S252-p 476131 GSAPLKSsGQHQNDK molecular association, regulation; activity, inhibited; phosphorylation carcinogenesis, inhibited; cell growth, inhibited; cell growth, induced; cell motility, inhibited; transcription, induced; signaling pathway regulation SMAD4(INDUCES) 28684116; 31016558 2 11 0 inhibits Akt phosphorylation; decrease/inhibits STAT3 and Akt signaling -IL5RA IL5RA Membrane protein, integral; Receptor, cytokine Q01344 3568 3p26.2 human K379-ub 1883407601 FPPIPAPkSNIKDLF protein degradation cell differentiation, inhibited 35982175 1 0 0 translocation to and degradation in lysosomes, March2/3 negatively regulates eosinophil maturation, March2/3 de?ciency promotes eosinophilic airway in?ammation -PRKRA PACT Activator; RNA processing; RNA-binding O75569 8575 2q31.2 human S287-p 470038 PITVCHGsGISCGNA molecular association, regulation; enzymatic activity, induced apoptosis, altered; apoptosis, induced PACT(INDUCES); TRBP(DISRUPTS) 16982605; 21526770; 22473766; 26231208 4 0 0 PKR enzymatic activity induced; activates PKR -TTK TTK Cancer Testis Antigen (CTA); EC 2.7.12.1; KINASE; Kinase, protein; Protein kinase, Other; Protein kinase, dual-specificity (non-receptor) P33981 7272 6q14.1 human T33-p 2846502 KFKNEDLtDELSLNK enzymatic activity, inhibited; intracellular localization; enzymatic activity, induced cell cycle regulation 25265012; 26119734; 29502948; 36395767 9 24 12 autophosphorylation of this site is required for release TTK from kinetochore; causes decreased kinetochore localization of BubR1 and Mad2. -RBM17 RBM17 RNA splicing; RNA-binding; Spliceosome Q96I25 84991 10p15.1 human S222-p 3209223 EEQDRPRsPTGPSNS molecular association, regulation; phosphorylation RNA splicing, inhibited; RNA splicing, induced; cell motility, induced; cell growth, inhibited; transcription, inhibited; cell adhesion, inhibited RNA(DISRUPTS) 22615491; 23519612 2 41 0 induced cell invasion, enhanced Cortactin phosphorylation at ERK-dependent sites -ISX ISX DNA-binding Q2M1V0 91464 22q12.3 human S183-p 1874101900 RRLAPPTsCCPSAQD intracellular localization carcinogenesis, induced; cell motility, induced; cell growth, induced; transcription, induced 34265398 1 1 0 -SPRY2 SPRY2 Adaptor/scaffold; Inhibitor; Motility/polarity/chemotaxis O43597 10253 13q31.1 human Y269-p 3978701 FLPCLWCyLPAKGCL Sprouty activity, inhibited; phosphorylation transcription, altered 15637081 1 0 0 -Irf7 IRF7 DNA-binding; Transcription factor P70434 54123 7|7 F5 mouse S438-p 486438 SLGLCLSsTNSLYED transcription, induced DNA(INDUCES) 15743772; 33976210 2 0 0 -ITGB2 ITGB2 Cell adhesion; Cell surface; Membrane protein, integral; Motility/polarity/chemotaxis; Receptor, misc. P05107 3689 21q22.3 human T759-p 448535 PLFKSATtTVMNPKF Integrin_b_cyt molecular association, regulation kindlin-3(INDUCES) 23823319 2 0 0 -NEDD1 NEDD1 Cell cycle regulation Q8NHV4 121441 12q23.1 human S637-p 9379000 HSLLERYsVNEGLVA molecular association, regulation cell cycle regulation 19509060 2 1 0 important for binding of NEDD1 with gamma-tubulin -CDC25A CDC25A EC 3.1.3.48; Motility/polarity/chemotaxis; PHOSPHATASE; Protein phosphatase, dual-specificity P30304 993 3p21.31 human Y59-p 57761916 LQGLGSDyEQPLEVK molecular association, regulation PKM(INDUCES) 27485204 1 0 0 -Traf3ip2 TRAF3IP2 Apoptosis; UBIQUITIN LIGASE; Ubiquitin conjugating system; Ubiquitin ligase Q8N7N6 103213 10|10 B1 mouse S222-p 25687505 DLPGPLRsRELPPQF molecular association, regulation transcription, inhibited TRAF6(DISRUPTS) 22851696 1 0 0 -DDAH2 DDAH2 Apoptosis; EC 3.5.3.18; Hydrolase O95865 23564 6p21.33 human Y207-p 60179303 AVLTDHPyASLTLPD enzymatic activity, inhibited 27838434 1 0 0 -CASP9 CASP9 Apoptosis; EC 3.4.22.62; Protease P55211 842 1p36.21 human T125-p 449563 PEVLRPEtPRPVDIG activity, inhibited apoptosis, altered; apoptosis, induced 16287866; 17466630 7 4 10 inhibits apoptosis during mitosis -H3F3C H3 DNA-binding P84229 427887 chicken S28-p 455677 ATKAARKsAPATGGV Histone molecular association, regulation chromatin organization, altered; transcription, induced DNA(DISRUPTS) 17913747 50 18 0 -DUSP6 DUSP6 EC 3.1.3.16; EC 3.1.3.48; Motility/polarity/chemotaxis; PHOSPHATASE; Protein phosphatase, dual-specificity Q16828 1848 12q21.33 human S159-p 455265 DGSCSSSsPPLPVLG protein degradation 15632084 4 0 0 -TP53 p53 Activator; DNA-binding; Motility/polarity/chemotaxis; Nuclear receptor co-regulator; Transcription factor; Tumor suppressor P04637 7157 17p13.1 human K372-m1 2363903 HSSHLKSkKGQSTSR molecular association, regulation; protein stabilization; methylation; intracellular localization; protein conformation carcinogenesis, inhibited; cell growth, inhibited; apoptosis, induced; transcription, induced; transcription, altered DNA(INDUCES) 15525938; 17108971; 27270439; 27694900; 30881498; 31069954 7 0 0 -Prkch PKCH EC 2.7.11.13; KINASE; Kinase, protein; Protein kinase, AGC; Protein kinase, Ser/Thr (non-receptor) P23298 18755 12|12 C3 mouse S28-p 3074801 GLQPTRWsLRHSLFK C2 molecular association, regulation; intracellular localization cell growth, inhibited CTLA-4(INDUCES) 24705298 2 3 14 -Cdk6 CDK6 Cell cycle regulation; EC 2.7.11.22; KINASE; Kinase, protein; Protein kinase, CMGC; Protein kinase, Ser/Thr (non-receptor) Q64261 12571 5 A1|5 2.04 cM mouse D224-p 10359104 PLFRGSSdVDQLGKI Pkinase intracellular localization 19667758 1 0 0 -GCM1 GCM1 DNA-binding; Transcription factor Q9NP62 8521 6p12.1 human K156-sm 12004402 KGEHDHPkPETKLEA GCM molecular association, regulation transcription, inhibited DNA(DISRUPTS) 17646165 2 0 0 -UBA52-RPS27A-UBB-UBC ubiquitin Ubiquitin-like modifier P62988 2p16 human S20-p 14582508 ITLEVEPsDTIENVK ubiquitin enzymatic activity, induced 27425610 1 7 0 -DEF6 DEF6 GEF; GEF, Rac/Rho Q9H4E7 50619 6p21.31 human S597-p 4756642 SQGNRTPsPNSNEQQ activity, induced; molecular association, regulation transcription, induced IP3R1(INDUCES) 28993769 1 11 43 TCR stimulation-induced activation of NFAT, IL2, and IFNG, FasLG, CTLA4 and CD25 transcription -TK1 TK EC 2.7.1.21; KINASE; Kinase, other; Nucleotide Metabolism - pyrimidine; Xenobiotic Metabolism - drug metabolism - other enzymes P04183 7083 17q25.3 human S13-p 448816 LPTVLPGsPSKTRGQ protein degradation; molecular association, regulation; enzymatic activity, inhibited; enzymatic activity, induced TK(DISRUPTS) 12435275; 14697231; 25003822 4 15 1 TK phosphorylation-modulated [18F]FLT cellular retention; decreases tetramerization (increases dimer proportion) -APP APP Apoptosis; Cell surface; Membrane protein, integral; Receptor, misc.; Transcription factor P05067 351 21q21.3 human K724-ne 12124802 VITLVMLkKKQYTSI APP_amyloid transcription, inhibited Fe65(DISRUPTS) 18096514 1 0 0 -Myb Myb DNA-binding; Oncoprotein; Transcription factor P06876 17863 10 A3|10 9.75 cM mouse K441-ac 459083 DQTVKTQkENSIFRT Cmyb_C molecular association, regulation transcription, induced CBP(INDUCES) 11073948 1 2 0 -DGCR8 DGCR8 Nucleolus; RNA processing; RNA-binding Q8WYQ5 54487 22q11.21 human S397-p 25735891 FPLDEPDsMGADPGP protein stabilization 24239349 0 1 1 -Epor EPOR Membrane protein, integral; Receptor, cytokine P14753 13857 9 A3|9 7.93 cM mouse Y488-p 457448 DGPYSHPyENSLVPD carcinogenesis, induced; cell growth, induced 27998978 4 0 0 STAT5 acivation -HRAS HRas G protein; G protein, monomeric; G protein, monomeric, Ras; Motility/polarity/chemotaxis; Oncoprotein P01112 3265 11p15.5 human Y137-p 41198101 AQDLARSyGIPYIET Ras molecular association, regulation RASA1(INDUCES); RAF1(INDUCES) 25999467 2 1 0 -HDAC4 HDAC4 DEACETYLASE; Deacetylase; EC 3.5.1.98; Hydrolase; Nuclear receptor co-regulator; SUMO LIGASE P56524 9759 2q37.3 human S302-p 17797200 APGSGPSsPNNSSGS protein degradation; ubiquitination; intracellular localization cell motility, altered 21118993 1 0 0 -PARP1 PARP1 DNA repair, damage; EC 2.4.2.30; Nuclear envelope; Nuclear receptor co-regulator; Nucleolus; Transferase P09874 142 1q42.12 human S465-p 34729900 FLQDVSAsTKSLQEL enzymatic activity, induced 25069723 1 1 0 Non-apoptotic cell death induced -MYLK smMLCK EC 2.7.11.18; KINASE; Kinase, protein; Protein kinase, CAMK; Protein kinase, Ser/Thr (non-receptor) Q15746 4638 3q21.1 human T978-p 15423395 VPPPKPAtPDFRSVL molecular association, regulation; intracellular localization ACTN1(INDUCES) 34302892 1 3 2 -H2AX H2AX DNA repair, damage; DNA-binding; Helicase P16104 3014 11q23.3 human T136-p 455687 PSGGKKAtQASQEY_ molecular association, regulation; intracellular localization cell differentiation, inhibited; transcription, altered H1B(DISRUPTS) 16377563; 20356835; 33691101 6 14 11 -Cbx1 CBX1 Transcription factor P83917 12412 11 D|11 60.11 cM mouse S89-p 2906737 GGKRKADsDSEDKGE molecular association, regulation chromatin organization, altered; cell growth, induced; cell differentiation, induced; transcription, altered KRTAP1-1(INDUCES) 34214177 1 43 9 -POLI POLI DNA repair, damage; EC 2.7.7.7; Transferase Q9UNA4 11201 18q21.2 human K273-ub 22249762 GIGYKTAkCLEALGI protein degradation 26370087 1 5 0 -WNK1 WNK1 EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, Other; Protein kinase, Ser/Thr (non-receptor) Q9H4A3 65125 12p13.33 human S382-p 454105 KRASFAKsVIGTPEF Pkinase enzymatic activity, induced 17190791; 18270262; 22032326 9 10 3 -MALT1 MALT1 Adaptor/scaffold; Apoptosis; EC 3.4.22.-; Ligase; Nuclear export; Protease; UBIQUITIN LIGASE; Ubiquitin conjugating system Q9UDY8 10892 18q21.32 human S573-p 1869465811 GTEYSAEsLVRNLQW Peptidase_C14 carcinogenesis, induced; cell growth, induced; transcription, induced; signaling pathway regulation 31644910 1 1 0 activates transcription of NF-kB -PELI1 PELI1 Adaptor/scaffold; EC 6.3.2.-; EC 6.3.2.19; Ligase; UBIQUITIN LIGASE; Ubiquitin conjugating system; Ubiquitin ligase Q96FA3 57162 2p14 human T264-p 1881000300 EGLSHTPtVKHLEAL ubiquitination; enzymatic activity, induced carcinogenesis, induced; cell motility, induced 36841821 1 1 0 -ANXA2 ANXA2 Calcium-binding; Lipid-binding; Motility/polarity/chemotaxis P07355 302 15q22.2 human S26-p 450879 TPPSAYGsVKAYTNF molecular association, regulation; intracellular localization cell cycle regulation; cell motility, altered S100A10(DISRUPTS) 11106498; 12962548; 18412141; 21115493; 34331392 14 29 100 -GPR35 GPR35 GPCR, family 1; Membrane protein, integral; Membrane protein, multi-pass; Receptor, GPCR Q9HC97 2859 2q37.3 human S300-p 1876282808 PSAKAHKsQDSLCVT receptor internalization, induced; molecular association, regulation; intracellular localization ARR3(INDUCES) 35101446 1 1 0 -MYC Myc DNA-binding; Nucleolus; Oncoprotein; Transcription factor P01106 4609 8q24.21 human K66-sm 56403909 APSEDIWkKFELLPT Myc_N molecular association, regulation carcinogenesis, induced; cell growth, induced; transcription, induced JNK1(INDUCES) 27239040 1 0 0 -PDCD5 PDCD5 Apoptosis O14737 9141 19q13.11 human K20-ub 12246092 RLAELQAkHGDPGDA dsDNA_bind protein degradation; ubiquitination signaling pathway regulation 36578176 1 7 11 LNPPS suppresses the degradation of PDCD5 by masking its K20 site ubiquitination -PARP1 PARP1 DNA repair, damage; EC 2.4.2.30; Nuclear envelope; Nuclear receptor co-regulator; Nucleolus; Transferase P09874 142 1q42.12 human K521-ac 459007 EGINKSEkRMKLTLK molecular association, regulation transcription, induced NFkB-p105(INDUCES) 16204234 1 1 27 -BCAR1 P130Cas Adaptor/scaffold; Motility/polarity/chemotaxis P56945 9564 16q23.1 human Y267-p 451537 SQYGQEVyDTPPMAV cell growth, induced 26867768 3 21 285 metastases -RSC1A1 RSC1A1 Vesicle Q29106 pig S370-p 10433802 LHELLVIsSKPALEN intracellular localization 19765263 1 1 0 increases nuclear export -Htr1b 5-HT(1B) GPCR, family 1; Membrane protein, integral; Membrane protein, multi-pass; Receptor, GPCR P28334 15551 9 E1|9 44.61 cM mouse S154-p 10897604 ITDAVEYsAKRTPKR 7tm_1 activity, induced; receptor internalization, altered 19741007 1 0 0 -Cspg4 NG2 Cell adhesion; Membrane protein, integral Q00657 81651 8q24 rat T2314-p 483998 ELLQFCRtPNPALRN intracellular localization cell growth, altered 17591920 1 0 1 -MAP2K7 MKK7 EC 2.7.12.2; KINASE; Kinase, protein; Protein kinase, STE; Protein kinase, dual-specificity (non-receptor) O14733 5609 19p13.2 human T275-p 447698 LVDSKAKtRSAGCAA Pkinase enzymatic activity, induced transcription, altered 9312068 2 0 1 -Axin1 axin 1 Adaptor/scaffold; Tumor suppressor O35625 12005 17 A3.3|17 13.07 cM mouse T160-p 3072727 NGIVSRQtKPATKSF RGS molecular association, regulation signaling pathway regulation CTNNB1(DISRUPTS); APC(DISRUPTS); BTRC(DISRUPTS) 25735981 1 2 0 activates Wnt/beta-catenin signaling -SENP3 SENP3 DESUMOYLASE; EC 3.4.22.68; Nucleolus; Protease; Sumo-specific protease Q9H4L4 26168 17p13.1 human T145-p 36438202 YSKSTSLtFHWKLWG molecular association, regulation; intracellular localization NPM1(INDUCES) 25288641 1 1 0 ribosome biogenesis-28S rRNA maturation -SLC6A2 SLC6A2 Membrane protein, integral; Membrane protein, multi-pass; Transporter; Transporter, SLC family P23975 6530 16q12.2 human T258-p 465613 SLWKGVKtSGKVVWI SNF receptor internalization, induced; intracellular localization; activity, inhibited 16740633; 23979140 2 0 0 Raft-rich membrane domains serve as transit cargos for transporter internalization.; effect observed in T258, S259 double mutant -REPS1 REPS1 Vesicle Q96D71 85021 6q24.1 human S709-p 478670 PVRRRLKsEDELRPE receptor recycling, induced 33407999 1 62 511 -Jak2 JAK2 EC 2.7.10.2; KINASE; Kinase, protein; Oncoprotein; Protein kinase, TK; Protein kinase, tyrosine (non-receptor) Q62120 16452 19 C1|19 23.73 cM mouse Y372-p 7603504 FVSLIDGyYRLTADA Jak1_Phl protein stabilization; molecular association, regulation; phosphorylation; enzymatic activity, induced transcription, induced; signaling pathway regulation JAK2(INDUCES); STAT1(INDUCES) 21726629 2 2 0 dimerization; induces autophosphorylation at Y1007; regulates JAK-STAT signaling, stabilization in active conformation -NR4A1 Nur77 Apoptosis; DNA-binding; Nuclear receptor P22736 3164 12q13.13 human K577-sm 1873041100 LQRIFYLkLEDLVPP Hormone_recep protein degradation; ubiquitination transcription, inhibited 28622293 1 0 0 inhibits TNF-alpha and IL-1beta-induced NF-kB activity -Itpka ITPKA Carbohydrate Metabolism - inositol phosphate; EC 2.7.1.127; Kinase, lipid; Motility/polarity/chemotaxis Q8R071 228550 2|2 E5 mouse S119-p 4763186 LQQPRRLsTSSLSST molecular association, regulation neural plasticity; cytoskeletal reorganization 22389500 2 0 0 Phosphorylation at S119 inhibits the ITPKA and microtubule binding -CMKLR1 CMKLR1 GPCR, family 1; Membrane protein, integral; Membrane protein, multi-pass; Receptor, GPCR Q99788 1240 12q23.3 human S349-p 4713136 TGHSSYPsHRSFTKM receptor internalization, induced 24658352 1 7 0 -RAF1 RAF1 EC 2.7.11.1; KINASE; Kinase, protein; Oncoprotein; Protein kinase, Ser/Thr (non-receptor); Protein kinase, TKL P04049 5894 3p25.2 human S29-p 455310 FDGSSCIsPTIVQQF molecular association, regulation; intracellular localization; enzymatic activity, inhibited HRas(DISRUPTS) 15664191 3 13 2 -CTNNB1 CTNNB1 Actin-binding; Cell adhesion; Motility/polarity/chemotaxis; Nuclear receptor co-regulator; Oncoprotein; Transcription factor P35222 1499 3p22.1 human S675-p 457120 QDYKKRLsVELTSSL activity, induced; molecular association, regulation; protein stabilization; intracellular localization carcinogenesis, induced; cell motility, induced; cell growth, induced; transcription, induced; transcription, altered; signaling pathway regulation TCF4(INDUCES); HDAC1(DISRUPTS); p300(INDUCES); CDH1(INDUCES); BTRC(DISRUPTS) 16199882; 16476742; 20419129; 21822311; 22173096; 27162341; 27484798; 33815677; 33832512; 33914026; 34262144; 34799729; 35131384; 36000549; 36626902 40 55 17 -FPR1 FPR1 GPCR, family 1; Membrane protein, integral; Membrane protein, multi-pass; Motility/polarity/chemotaxis; Receptor, GPCR P21462 2357 19q13.41 human T339-p 450846 SDTATNStLPSAEVE receptor desensitization, altered; receptor internalization, altered 10514456 1 0 0 -Nfkbia IkB-alpha DNA-binding; Inhibitor Q63746 25493 6q23 rat Y42-p 448737 DSMKDEDyEQMVKEL activity, induced cell growth, altered 15935065 15 1 28 -H2AX H2AX DNA repair, damage; DNA-binding; Helicase P16104 3014 11q23.3 human K15-ub 55610204 GKARAKAkSRSSRAG Histone intracellular localization DNA repair, induced; carcinogenesis, inhibited; cell growth, inhibited; DNA repair, altered 22980979; 27345151; 32213544; 35598681 5 0 0 -MCM2 MCM2 DNA-binding; EC 3.6.4.12 P49736 4171 3q21.3 human S41-p 452312 RTDALTSsPGRDLPP activity, induced; molecular association, regulation cell cycle regulation; chromatin organization, altered DNA(NOT_REPORTED); DNA(INDUCES) 16446360; 16899510 8 60 23 MMCM2 phosphorylated forms are differentially bound to chromatin. ; regulates ATPase activity in vitro -MAVS MAVS Adaptor/scaffold; Membrane protein, integral Q7Z434 57506 20p13 human R43-me 1883504203 ARDQDRLrATCTLSG activity, inhibited 36028484 1 1 0 PRMT9-mediated MAVS methylation inhibits MAVS aggregation and activation. -CRY2 CRY2 DNA-binding; Lyase Q49AN0 1408 11p11.2 human T300-p 40584904 KKVKRNStPPLSLFG protein degradation; molecular association, regulation; ubiquitination FBXW7(INDUCES) 25855785 1 0 0 faster turnover rate in the presence of FBXW7 -CTNNB1 CTNNB1 Actin-binding; Cell adhesion; Motility/polarity/chemotaxis; Nuclear receptor co-regulator; Oncoprotein; Transcription factor P35222 1499 3p22.1 human S311-p 1881000308 LAYGNQEsKLIILAS protein stabilization; molecular association, regulation; intracellular localization carcinogenesis, induced; cell motility, induced; cell growth, induced; transcription, altered; signaling pathway regulation TCF4(NOT_REPORTED) 36793862 1 1 0 induces ?-catenin/AP-1/PLK1 signaling -FER Fer EC 2.7.10.2; KINASE; Kinase, protein; Oncoprotein; Protein kinase, TK; Protein kinase, tyrosine (non-receptor) P16591 2241 5q21.3 human Y402-p 457934 EPPPVVNyEEDARSV cell motility, inhibited 37196766 2 39 613 -MDC1 MDC1 Cell cycle regulation Q14676 9656 6p21.33 human T220-p 4213801 AFNLNSDtDVEEGQQ molecular association, regulation cell cycle regulation NBS1(INDUCES) 18678890 1 1 5 MDC1-NBS1 interaction regulates intra-S-phase checkpoint activation -FOS Fos DNA-binding; Motility/polarity/chemotaxis; Oncoprotein; Transcription factor P01100 2353 14q24.3 human T232-p 448491 GGLPEVAtPESEEAF activity, induced; intracellular localization; phosphorylation carcinogenesis, induced; cell motility, induced; transcription, induced; transcription, altered 16055710; 17018293; 23667255; 27014871; 7816602 6 0 0 -PDHA1 PDHA1 Amino Acid Metabolism - valine, leucine and isoleucine biosynthesis; Carbohydrate Metabolism - butanoate; Carbohydrate Metabolism - citrate (TCA) cycle; Carbohydrate Metabolism - glycolysis and gluconeogenesis; Carbohydrate Metabolism - pyruvate; EC 1.2.4.1; Mitochondrial; Oxidoreductase P08559 5160 Xp22.12 human S300-p 448259 SMSDPGVsYRTREEI E1_dh activity, induced; protein degradation; molecular association, regulation; ubiquitination; enzymatic activity, inhibited carcinogenesis, induced; cell growth, induced; apoptosis, inhibited emerin(INDUCES) 11092882; 17065338; 22289032; 25243911; 25404640; 27357730; 28122247; 30697423; 30797950; 32993545; 34667275; 36071546; 7782287 53 76 476 -SSTR2 SSTR2 GPCR, family 1; Membrane protein, integral; Membrane protein, multi-pass; Receptor, GPCR P30874 6752 17q25.1 human S341-p 7652103 GTDDGERsDSKQDKS receptor desensitization, induced; receptor internalization, induced; receptor recycling, induced; receptor internalization, altered 21330405; 21343287; 22538189; 24565897; 24637622; 25012983 10 0 0 -TP53 p53 Activator; DNA-binding; Motility/polarity/chemotaxis; Nuclear receptor co-regulator; Transcription factor; Tumor suppressor P04637 7157 17p13.1 human S9-p 447538 EEPQSDPsVEPPLSQ P53_TAD molecular association, regulation; acetylation; intracellular localization; protein conformation; phosphorylation cell cycle regulation; apoptosis, altered; carcinogenesis, inhibited; apoptosis, induced; transcription, induced; transcription, altered 11875057; 12860987; 14665630; 15322239; 18769132; 18794113; 34282274; 36007676 39 3 1 CRp53 -Ctnnb1 CTNNB1 Actin-binding; Cell adhesion; Motility/polarity/chemotaxis; Nuclear receptor co-regulator; Oncoprotein; Transcription factor Q02248 12387 9 F4|9 72.19 cM mouse K233-sm 1883364802 EGLLAIFkSGGIPAL intracellular localization 36306558 1 0 0 epithelial barrier dysfunction in asthma -Cacna1a CACNA1A Channel, calcium; Membrane protein, integral; Membrane protein, multi-pass P97445 12286 8 C2|8 40.95 cM mouse S2363-p 4713052 AHDAYSEsEDDWC__ activity, induced 32630015 1 3 0 regulates Ca2+ entry and insulin secretion in pancreatic-beta cells -Dicer1 DICER1 Cell development/differentiation; EC 3.1.26.3; Helicase; RNA processing; RNA-binding; Ribonuclease Q8R418 192119 12 E|12 54.83 cM mouse S1456-p 31084113 IDSMLMGsGAFVRKI Ribonuclease_3 protein degradation 29907159 1 3 0 inflammatory response -Stxbp5 STXBP5 Vesicle Q9WU70 81022 1p13 rat K298-sm 31957310 EPCKPILkVEFKTTR LLGL molecular association, regulation exocytosis, inhibited STX1A(INDUCES) 28325894 2 0 0 -Rb1 Rb Nuclear receptor co-regulator; Oncoprotein; Transcription, coactivator/corepressor; Tumor suppressor P33568 24708 15q11 rat S780-p 450022 PIPHIPRsPYKFSSS Rb_C molecular association, regulation HDAC1(INDUCES) 19081374 12 20 79 -TRIM28 TIF1B EC 6.3.2.-; KINASE; Kinase, protein; Ligase; Nuclear receptor co-regulator; Protein kinase, atypical; SUMO LIGASE; SUMO ligase; Transcription, coactivator/corepressor; UBIQUITIN LIGASE; Ubiquitin conjugating system; Ubiquitin ligase Q13263 10155 19q13.43 human Y517-p 464439 PGSTTEDyNLIVIER molecular association, regulation; phosphorylation DNA repair, induced HP1 alpha(INDUCES) DNA(NOT_REPORTED) 23645696 1 6 131 stimulates phosphorylation of TIF1B S473 and TIF1B S824 in DNA damage response; involved in DNA damage response; inhibits association of HP1alpha with chromatin -Traf2 TRAF2 Autophagy; EC 6.3.2.-; Ligase; UBIQUITIN LIGASE; Ubiquitin conjugating system; Ubiquitin ligase P39429 22030 2|2 A3 mouse K38-ub 486267 KYLCSACkNILRRPF zf-C3HC4 protein degradation 11909853 1 0 0 -Rb1cc1 RB1CC1 Autophagy; DNA-binding; Transcription factor; Tumor suppressor Q9ESK9 12421 1|1 A1 mouse S536-p 470654 AEKSKREsFGKLFRK ATG17_like intracellular localization carcinogenesis, inhibited 35220675 1 1 0 -ATF1 ATF-1 Transcription factor P18846 466 12q13.12 human S36-p 465558 AQQVSSLsESEESQD molecular association, regulation; phosphorylation CBP(DISRUPTS) 20730097 4 1 0 primes for S47/S50/S51 phosphorylation -PTGER4 PTGER4 GPCR, family 1; Membrane protein, integral; Membrane protein, multi-pass; Receptor, GPCR P35408 5734 5p13.1 human S382-p 450698 GHSRSFIsRELKEIS molecular association, regulation ARRB1(INDUCES) 14709160 1 0 0 -RAPH1 RAPH1 Adaptor/scaffold; Motility/polarity/chemotaxis Q70E73 65059 2q33.2 human Y456-p 26348502 NVYYGQDyRNKYKAP PH molecular association, regulation cell motility, induced 26996666 2 0 0 Lpd-Scar/WAVE interaction is positively regulated by c-Abl and c-Src, breast cancer cell invasion -DVL3 DVL3 Motility/polarity/chemotaxis Q92997 1857 3q27.1 human S639-p 34668134 HSHRSHHsLASSLRS Dsh_C intracellular localization 24993822 1 1 0 -SMAD3 SMAD3 DNA-binding; Nuclear receptor co-regulator; Transcription factor P84022 4088 15q22.33 human S425-p 448336 SIRCSSVs_______ activity, induced; intracellular localization; protein conformation carcinogenesis, induced; cell differentiation, induced; cell motility, altered; transcription, induced; transcription, altered; signaling pathway regulation 19115199; 21148321; 25140527; 31995604; 34003249; 35075279; 36461015; 9380693 41 0 5 The triple mutants(S422/423/425A and S422/423/425D) were used in these experiments -PPP1R14D GBPI-1 Inhibitor; Protein phosphatase, regulatory subunit Q9NXH3 54866 15q15.1 human T58-p 450935 SRRPSRLtVKYDRGQ PP1_inhibitor phosphorylation 12974676 1 0 0 Phosphorylated GBPI-1 inhibits PP1 activity. Point mutant does not. -RBM7 RBM7 RNA-binding Q9Y580 10179 11q23.2 human S136-p 453069 QIIQRSFsSPENFQR molecular association, regulation 14-3-3 beta(INDUCES); GADD45A(DISRUPTS) 25189701 2 50 103 14-3-3 protein binding -Tln1 talin 1 Cytoskeletal; Motility/polarity/chemotaxis P26039 21894 4|4 A5 mouse S425-p 1984203 TMLEDSVsPKKSTVL cell motility, induced; cell growth, induced 36207442 7 44 2 -Ncor1 N-CoR1 Nuclear receptor co-regulator; Transcription, coactivator/corepressor Q60974 20185 11|11 B2 mouse K1117-sm 3755601 AAPLTYIkQEEFSPR transcription, inhibited 16421255 1 4 0 -Gjb3 GJB3 Channel, misc.; Membrane protein, integral; Membrane protein, multi-pass P28231 14620 4 D2.2|4 61.48 cM mouse S263-p 2907501 ASEKLQAsAPSLTPI activity, induced; protein stabilization 15023533 1 2 0 -Fxyd1 PLM Cell surface; Channel, misc.; Membrane protein, integral Q9Z239 56188 7|7 B1 mouse S88-p 451425 RSSIRRLsSRRR___ activity, induced; intracellular localization 16371442; 21957166 27 3 74 Na K pump activity; After stimulation with phorbol ester. -FFAR4 GPR120 iso1 GPCR, family 1; Lipid-binding; Membrane protein, integral; Membrane protein, multi-pass; Receptor, GPCR Q5NUL3-1 338557 10q23.33 human T365-p 33638004 KGAILTDtSVKRNDL receptor internalization, induced; molecular association, regulation ARR3(INDUCES) 24817122 2 1 0 -IRF4 IRF4 DNA-binding; Oncoprotein; Transcription factor Q15306 3662 6p25.3 human Y62-p 28700300 KHAGKQDyNREEDAA IRF activity, induced transcription, induced 23804646 1 0 0 -Rps6 S6 Translation P62755 29304 5q32 rat S235-p 448092 IAKRRRLsSLRASTS signaling pathway regulation 21949366 246 60 972 -ATM ATM DNA repair, damage; EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, Ser/Thr (non-receptor); Protein kinase, atypical; Tumor suppressor Q13315 472 11q22.3 human S367-p 467198 DTRSLEIsQSYTTTQ enzymatic activity, induced 21149446 3 9 2 -KIF20A KIF20A Microtubule-binding; Motor O95235 10112 5q31.2 human S878-p 4712595 RILRSRRsPLLKSGP molecular association, regulation; intracellular localization; protein conformation cell cycle regulation; cytoskeletal reorganization AurB(DISRUPTS); INCENP(DISRUPTS) 24656812; 27939310 2 9 0 favours solubility, inhibits microtubule binding; inhibits abscission -SNAI2 Snail2 Apoptosis; C2H2-type zinc finger protein; Motility/polarity/chemotaxis; Transcription factor O43623 6591 8q11.21 human T208-p 25311911 QGHIRTHtGEKPFSC protein stabilization carcinogenesis, induced; cell motility, induced 35859006 1 0 1 -PXN PXN Adaptor/scaffold; Cell adhesion; Cytoskeletal; Motility/polarity/chemotaxis P49023 5829 12q24.23 human Y118-p 448604 VGEEEHVySFPNKQK Paxillin molecular association, regulation; intracellular localization; phosphorylation cell differentiation, inhibited; carcinogenesis, induced; cell motility, induced; cell adhesion, induced; signaling pathway regulation; cell adhesion, inhibited; autophagy, induced; cell growth, induced; cytoskeletal reorganization TACE(INDUCES); ERK2(INDUCES); ERK1(INDUCES); DRP1(INDUCES); CBL(INDUCES); LC3A(INDUCES) 23317503; 26091349; 26697169; 28415719; 33823745; 34226698; 34335982; 34475475; 35297710 83 79 2519 -DAPP1 DAPP1 Adaptor/scaffold Q9UN19 27071 4q23 human S141-p 14510068 EEPSIYEsVRVHTAM molecular association, regulation; phosphorylation; enzymatic activity, induced signaling pathway regulation PLCG1(INDUCES) 22981863 1 1 4 -IGF1R IGF1R EC 2.7.10.1; KINASE; Kinase, protein; Membrane protein, integral; Protein kinase, TK; Protein kinase, tyrosine (receptor) P08069 3480 15q26.3 human S1312-p 2091901 LDPSASSsSLPLPDR activity, induced; phosphorylation cell differentiation, altered; apoptosis, altered; cell growth, altered 10746631; 10786694 2 1 0 observed in Y980F + S1310-1313A; ERK phosphorylation -TARDBP TDP-43 RNA-binding Q13148 23435 1p36.22 human S48-p 18914091 LRYRNPVsQCMRGVR TDP43_N molecular association, regulation; protein conformation TDP-43(DISRUPTS) 29438978; 35040651 2 1 1 -CTPS1 CTPS EC 6.3.4.2; Ligase; Motility/polarity/chemotaxis; Nucleotide Metabolism - pyrimidine P17812 1503 1p34.2 human S575-p 449144 SDRSGSSsPDSEITE molecular association, regulation; activity, inhibited; phosphorylation PIN1(INDUCES) 17681942; 18600551 2 73 11 -Cdh5 CDH5 Cell adhesion; Membrane protein, integral; Motility/polarity/chemotaxis P55284 12562 8 D3|8 53.04 cM mouse Y658-p 456048 GEMDTTSyDVSVLNS activity, induced; molecular association, regulation; receptor recycling, induced GPSM2(INDUCES); CTNND1(DISRUPTS) 20530207; 28712573; 32327488 13 0 0 induces VE-cadherin trafficking to adherent junctions -ESR1 ER-alpha DNA-binding; Nuclear receptor; Transcription factor P03372 2099 6q25.1-q25.2 human K268-sm 3617605 GGRMLKHkRQRDDGE molecular association, regulation transcription, induced DNA(INDUCES) 15961505 1 0 0 -DDIT3 DDIT3 Autophagy; DNA-binding; Oncoprotein; Transcription factor P35638 1649 12q13.3 human S14-p 455501 PFSFGTLsSWELEAW activity, inhibited transcription, inhibited 12876286 1 0 0 -IL2RB IL2RB Membrane protein, integral; Receptor, cytokine P14784 3560 22q12.3 human Y364-p 455360 SCFTNQGyFFFHLPD molecular association, regulation transcription, induced SHC1(INDUCES) 10602027; 18348982; 7499411; 8643566 5 0 0 mediated by PI3K pathway through Y364 -Ybx1 YB-1 RNA processing; RNA splicing; RNA-binding; Transcription factor P62960 22608 4|4 D2.1 mouse Y70-p 3797338 WFNVRNGyGFINRND CSD carcinogenesis, induced; translation, induced 36044842 1 0 24 -MYL9 MRLC1 Contractile; Motility/polarity/chemotaxis P24844 10398 20q11.23 human T19-p 1863501 KKRPQRAtSNVFAMF activity, induced; molecular association, regulation; intracellular localization cell adhesion, induced; cytoskeletal reorganization; signaling pathway regulation 22136066; 26169356; 31834925; 37064875 28 53 281 -DGCR8 DGCR8 Nucleolus; RNA processing; RNA-binding Q8WYQ5 54487 22q11.21 human S271-p 3208077 EEKYGGDsDHPSDGE protein stabilization 24239349 1 33 3 -Eef1a1 EEF1A1 Nucleolus; Translation; Translation elongation P10126 13627 9|9 E1 mouse K165-m1 8113920 TEPPYSQkRYEEIVK GTP_EFTU molecular association, regulation translation, altered EEF1D(DISRUPTS); eEF1B(DISRUPTS); EEF1G(DISRUPTS) 28108655 2 8 46 -Smarca2 SMARCA2 EC 3.6.1.-; EC 3.6.4.-; Helicase; Nuclear receptor co-regulator; Transcription, coactivator/corepressor Q6DIC0 67155 19 C1|19 21.17 cM mouse K1540-ac 460621 EKGRDTGkGKKRPNR molecular association, regulation; protein conformation cell growth, induced; transcription, inhibited Rb(DISRUPTS) DNA(DISRUPTS) 14657023 1 1 67 -P2RX3 P2X3 Channel, ligand-gated; Membrane protein, integral; Membrane protein, multi-pass P56373 5024 11q12.1 human T134-p 458895 LPGGGILtGRCVNYS P2X_receptor receptor desensitization, altered 16226373 1 0 0 -PRKCE PKCE EC 2.7.11.13; KINASE; Kinase, protein; Protein kinase, AGC; Protein kinase, Ser/Thr (non-receptor) Q02156 5581 2p21 human Y573-p 764200 TFCGTPDyIAPEILQ Pkinase molecular association, regulation PLCG1(INDUCES) 17561374 1 0 0 -KDR VEGFR2 EC 2.7.10.1; KINASE; Kinase, protein; Membrane protein, integral; Protein kinase, TK; Protein kinase, tyrosine (receptor) P35968 3791 4q12 human Y801-p 450277 GGELKTGyLSIVMDP activity, induced; molecular association, regulation; phosphorylation PIK3R1(INDUCES) 14532277; 17303569 4 1 2 PIK3R1, eNOS, and AKT phosphorylation; necessary for TNF but not VEGF activation of AKT; stimulates NO2 release -RIGI RIGI EC 3.6.4.13; Hydrolase O95786 23586 9p21.1 human K193-ub 486288 WIVEKGIkDVETEDL protein degradation 31881323 3 3 0 -ERBB4 HER4 EC 2.7.10.1; KINASE; Kinase, protein; Membrane protein, integral; Protein kinase, TK; Protein kinase, tyrosine (receptor) Q15303 2066 2q34 human Y1242-p 451502 KAFDNPDyWNHSLPP molecular association, regulation GRB2(INDUCES); Arg(INDUCES); SHC1(INDUCES) 16729043; 18721752; 8617750 2 2 3 -Kcnk18 KCNK18 Channel, ligand-gated; Channel, potassium; Membrane protein, integral; Membrane protein, multi-pass Q6VV64 332396 19|19 D3 mouse S279-p 13383301 RLSCSILsNLDEVGQ activity, inhibited 20215114; 22145024 3 0 0 K+ channel activity inhibited -Sdc1 syndecan-1 Extracellular matrix; Membrane protein, integral; Motility/polarity/chemotaxis P18828 20969 12 A1.1|12 3.94 cM mouse S286-p 469564 MKKKDEGsYSLEEPK Syndecan intracellular localization 16807246 1 8 1 -Kit Kit EC 2.7.10.1; KINASE; Kinase, protein; Membrane protein, integral; Oncoprotein; Protein kinase, TK; Protein kinase, tyrosine (receptor) P05532 16590 5 C3.3|5 39.55 cM mouse Y573-p 448015 INGNNYVyIDPTQLP cell growth, inhibited 28923937 9 3 12 -SNRPB snRNP B1 RNA processing; RNA splicing; RNA-binding; Spliceosome P14678 6628 20p13 human R112-m2 476754 GIGRAAGrGIPAGVP molecular association, regulation SMN(INDUCES) 11720283 1 7 26 -Becn1 beclin 1 Adaptor/scaffold; Autophagy; Membrane protein, peripheral O88597 56208 11|11 D mouse S14-p 25268704 SSSTMQVsFVCQRCS carcinogenesis, induced; autophagy, induced; cell growth, induced 23685627; 35246531 11 1 0 -TP53BP1 53BP1 DNA repair, damage; Transcription, coactivator/corepressor Q12888 7158 15q15.3 human R1396-me 2344821 GKAPVTPrGRGRRGR molecular association, regulation DNA(INDUCES) 16294045 2 0 0 -IGF2BP2 IGF2BP2 RNA-binding; Translation Q9Y6M1 10644 3q27.2 human K505-sm 1881342901 EENFFNPkEEVKLEA protein stabilization cell growth, induced 34345216 1 0 0 promotes vasculogenic mimicry (VM) formation in glioma cells -Cd22 CD22 Cell surface; Membrane protein, integral P35329 12483 7 B1|7 19.26 cM mouse Y783-p 458398 AMDDTVSyAILRFPE molecular association, regulation; activity, inhibited; phosphorylation SHP-1(INDUCES) 18024433; 27276708 5 0 1 negatively regulate calcium signal -Grin2c NMDAR2C Channel, calcium; Channel, ligand-gated; Membrane protein, integral; Membrane protein, multi-pass Q00961 24411 10q32.1 rat S1083-p 7979604 GPRPRHAsLPSSVAE molecular association, regulation; intracellular localization 14-3-3 beta(INDUCES); 14-3-3 theta(INDUCES); 14-3-3 zeta(INDUCES); 14-3-3 epsilon(INDUCES); 14-3-3 gamma(INDUCES); 14-3-3 eta(INDUCES) 19477150; 26229101 2 0 0 regulates GluN2C-containing NMDAR receptor trafficking -KCNB1 Kv2.1 Channel, cation; Channel, ligand-gated; Channel, potassium; Membrane protein, integral; Membrane protein, multi-pass Q14721 3745 20q13.13 human K474-sm 25087004 KNGENMGkKDKVQDN Kv2channel exocytosis, inhibited 31085831 2 1 0 controlled the occurrence of membrane fusion -SP1 SP1 C2H2-type zinc finger protein; DNA-binding; Transcription factor P08047 6667 12q13.13 human S42-p 3180261 FSQARSSsTGSSSST protein stabilization; molecular association, regulation carcinogenesis, induced; cell motility, induced; transcription, induced; signaling pathway regulation DNA(INDUCES) 22718198 1 1 0 AKT/SP1/CCR7 pathway -HSP90AA1 HSP90A Chaperone; Heat shock protein P07900 3320 14q32.31 human R386-me 1871626200 PEYLNFIrGVVDSED HSP90 molecular association, regulation apoptosis, inhibited AHSA1(INDUCES) 31765670 1 1 0 -EIF2AK4 GCN2 EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, Other; Protein kinase, Ser/Thr (non-receptor); Translation Q9P2K8 440275 15q15.1 human T899-p 455461 SDPSGHLtGMVGTAL Pkinase protein stabilization; molecular association, regulation apoptosis, induced; translation, induced ARRB1(DISRUPTS); ARRB2(DISRUPTS) 25589675; 36898579 5 0 0 -Xrcc6 Ku70 DNA repair, damage; DNA-binding; EC 3.6.4.-; EC 4.2.99.-; Helicase; Nuclear receptor co-regulator; RNA-binding P23475 14375 15 E1|15 38.33 cM mouse S49-p 10211800 ASRAMFEsQGEDELT Ku_N molecular association, regulation BAX(DISRUPTS) 19664609 2 0 0 kainate treatment increases interaction of Ku70 with Bax -FBXL20 FBXL20 UBIQUITIN LIGASE; Ubiquitin ligase Q96IG2 84961 17q12 human S255-p 1875005606 KLQSLCAsGCSNITD protein degradation; molecular association, regulation carcinogenesis, inhibited; cell growth, inhibited; apoptosis, induced FBXO31(INDUCES) 34587475 1 0 0 -Gja1 GJA1 Channel, misc.; Membrane protein, integral; Membrane protein, multi-pass; Motility/polarity/chemotaxis P23242 14609 10 B4|10 28.64 cM mouse S364-p 450183 AIVDQRPsSRASSRA intracellular localization; protein conformation 17714073 6 8 0 S363, S364 phosphorylation prevent an antibody to the Cx43 C-terminus. -KCNK3 KCNK3 Channel, potassium; Membrane protein, integral; Membrane protein, multi-pass O14649 3777 2p23.3 human S336-p 21336507 IPRDLSTsDTCVEQS activity, inhibited 21838752 1 1 1 -LTF LTF EC 3.4.21.-; Protease; Secreted; Secreted, signal peptide P02788 4057 3p21.31 human K352-sm 41400402 TAIQNLRkSEEEVAA Transferrin transcription, inhibited 26090800 1 0 0 -CNTROB LIP8 Cell cycle regulation Q8N137 116840 17p13.1 human S41-p 27565613 VTSQLYAsLRLSRQA cell motility, inhibited 23291182 1 0 0 -Maf MAF Cell development/differentiation; DNA-binding; Oncoprotein; Transcription factor; Tumor suppressor P54843 17132 8 E1|8 62.61 cM mouse K33-sm 8474100 DLMKFEVkKEPVETD molecular association, regulation; intracellular localization transcription, inhibited DNA(DISRUPTS) 19553542; 20127678 2 0 0 recruitment of MAF to the IL-4 gene -MAPT Tau iso8 ACETYLTRANSFERASE; Acetyltransferase; Cytoskeletal P10636-8 4137 17q21.31 human S404-p 449082 PVVSGDTsPRHLSNV O-GlcNAc glycosylation; molecular association, regulation; protein processing; intracellular localization; protein conformation; phosphorylation apoptosis, induced; cytoskeletal reorganization TUBA1A(DISRUPTS); TUBA4A(DISRUPTS); Tau iso8(INDUCES); TUBB(DISRUPTS) 10818091; 11034902; 12414518; 14761950; 15190058; 15542598; 16478768; 16687396; 18052981; 18725412; 19451179; 34220449; 35298090; 36079767 145 54 69 -RPL11 RPL11 Motility/polarity/chemotaxis; Nucleolus; Ribosomal; Translation P62913 6135 1p36.11 human K96-ne 12067614 VREYELRkNNFSDTG Ribosomal_L5_C protein stabilization; intracellular localization 19713960 1 0 0 -FHIT FHIT DNA replication; EC 3.6.1.29; Hydrolase; Motility/polarity/chemotaxis; Nucleotide Metabolism - purine; Tumor suppressor P49789 2272 3p14.2 human Y114-p 447802 FHRNDSIyEELQKHD protein degradation; intracellular localization; enzymatic activity, inhibited; activity, inhibited cell cycle regulation; apoptosis, altered; apoptosis, induced; cell growth, altered HSP60(INDUCES); FDXR(INDUCES) 15835917; 16407838; 17142325; 19004824 4 1 0 localization to the mitochondria; Overepression of wt FHIT promotes apoptosis but not the Y113A or Y113F mutation. -IL6ST gp130 Membrane protein, integral; Receptor, cytokine P40189 3572 5q11.2 human T890-p 455688 GQVERFEtVGMEAAT molecular association, regulation 12361954 1 0 1 -Tagln TAGLN Actin-binding; Motility/polarity/chemotaxis; Nuclear receptor co-regulator P31232 25123 8q22 rat S181-p 469978 VIGLQMGsNRGASQA Calponin protein degradation; molecular association, regulation; ubiquitination; phosphorylation cytoskeletal reorganization; signaling pathway regulation PKCD(DISRUPTS) 22798525 3 15 14 p47phox phosphorylation, PKCD-p47phox signaling, ROS production induced with vascular remodelling -PRLR PRLR Membrane protein, integral; Receptor, cytokine P16471 5618 5p13.2 human T415-p 449611 AGGSKCStWPLPQPS molecular association, regulation; phosphorylation transcription, altered 14-3-3 zeta(INDUCES); 14-3-3 gamma(INDUCES) 12819209 1 0 0 phosphorylation reduces tyrosine phosphorylation after prolactin stimulation as well as activation of ERK and AKT -MLXIP MLXIP Q9HAP2 22877 12q24.31 human Y222-p 40556408 IEIVIREyHKWRTYF molecular association, regulation; intracellular localization carcinogenesis, induced; cell growth, induced; apoptosis, inhibited; transcription, inhibited 14-3-3 beta(INDUCES) DNA(DISRUPTS) 36398713 1 1 0 -LPIN1 LPIN1 EC 3.1.3.4; Phosphatase, lipid Q14693 23175 2p25.1 human Y795-p 1871177712 FPNTEPFyAAFGNRP LNS2 enzymatic activity, induced carcinogenesis, induced; cell growth, induced 33203880 1 1 0 Activity of PAP, increase glycolipid synthesis -Snap23 SNAP23 Vesicle O70377 64630 3q35 rat S160-p 4148814 ENLTQVGsILGNLKN exocytosis, altered 20967886 2 18 14 -Dab1 DAB1 iso3 Adaptor/scaffold P97318-3 13131 4 C6|4 47.79 cM mouse S246-p 479425 PVSSLVQsPAAERAE protein degradation; phosphorylation 16529723 1 0 0 enhances tyrosine phosphorylation and protein degradation -Ets1 Ets-1 DNA-binding; Motility/polarity/chemotaxis; Oncoprotein; Transcription factor P27577 23871 9 A4|9 17.97 cM mouse S282-p 449317 NSLQRVPsYDSFDYE Ets1_N_flank molecular association, regulation; acetylation; intracellular localization transcription, inhibited DNA(DISRUPTS) 30865889 7 10 87 induce acetylation of FOXO1 and suppress gluconeogenesis -Tbc1d4 AS160 GAP; GAP, Rab Q8BYJ6 210789 14|14 E2.3 mouse S758-p 455924 EGRKRTSsTCSNESL phosphorylation 19923418 10 10 48 TBC1D4 S318/S588/T642/S751A mutation decreases phosphorylation of S711 -GRK7 GRK7 EC 2.7.11.14; EC 2.7.11.16; KINASE; Kinase, protein; Protein kinase, AGC; Protein kinase, Ser/Thr (non-receptor) Q8WTQ7 131890 3q23 human S36-p 456355 ELQRRRRsLALPGLQ enzymatic activity, inhibited 15946941 2 0 0 reaction in vitro -CDK9 CDK9 Cell cycle regulation; EC 2.7.11.22; EC 2.7.11.23; KINASE; Kinase, protein; Nuclear receptor co-regulator; Protein kinase, CMGC; Protein kinase, Ser/Thr (non-receptor) P50750 1025 9q34.11 human S90-p 41625400 EICRTKAsPYNRCKG Pkinase transcription, induced 23140174 2 0 0 Tat-induced HIV-1 transcription -USP9X USP9X DEUBIQUITINASE; EC 3.4.19.12; Protease; Ubiquitin conjugating system; Ubiquitin-specific protease Q93008 8239 Xp11.4 human S2547-p 483796 YEGSEEVsPPQTKDQ molecular association, regulation; enzymatic activity, induced WIT1(INDUCES) 32152317 1 28 1 -EZH2 EZH2 EC 2.1.1.43; METHYLTRANSFERASE; Methyltransferase; Methyltransferase, protein lysine Q15910 2146 7q36.1 human Y641-p 31825502 KNEFISEyCGEIISQ SET protein stabilization; molecular association, regulation; ubiquitination BTRC(INDUCES) 24469040 1 0 0 -Epha8 EphA8 EC 2.7.10.1; KINASE; Kinase, protein; Membrane protein, integral; Protein kinase, TK; Protein kinase, tyrosine (receptor) O09127 13842 4|4 D3 mouse Y838-p 448559 LAYGERPyWNMTNQD PK_Tyr_Ser-Thr enzymatic activity, induced cell adhesion, altered 10498895 1 0 0 Y383 phosphorylation is required for efficient phosphorylation of Y615 and other major sites. -ATM ATM DNA repair, damage; EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, Ser/Thr (non-receptor); Protein kinase, atypical; Tumor suppressor Q13315 472 11q22.3 human S2996-p 7433302 QECKRNLsDIDQSFN enzymatic activity, induced carcinogenesis, induced; DNA repair, induced 21149446; 33568520 4 12 0 -POLH POLH DNA repair, damage; EC 2.7.7.7; Transferase Q9Y253 5429 6p21.1 human K494-sm 1877365909 AAERQKVkEASLSSL intracellular localization; enzymatic activity, inhibited 32350109 1 1 0 -GPS2 GPS2 Cell cycle regulation; G protein regulator, misc.; Inhibitor; Nuclear receptor co-regulator; Transcription, coactivator/corepressor Q13227 2874 17p13.1 human R323-m1 11263012 IQHSQNPrFYHK___ molecular association, regulation HLAA(INDUCES) 19917673 1 1 0 there were no differences in binding of unmethylated, mono-methylated, or di-methylated peptides -LDLRAP1 LDLRAP1 Q5SW96 26119 1p36.11 human S14-p 3198716 AGRALIRsPSLAKQS cell cycle regulation 21778424 1 24 6 -Elk4 ELK4 DNA-binding; Transcription, coactivator/corepressor P41158 13714 1|1 E4 mouse S386-p 4317601 LSPFAPLsPARLQGA cell growth, altered 18356083 3 0 0 pro-B cell expansion -CTNNB1 CTNNB1 Actin-binding; Cell adhesion; Motility/polarity/chemotaxis; Nuclear receptor co-regulator; Oncoprotein; Transcription factor P35222 1499 3p22.1 human S45-p 447488 GATTTAPsLSGKGNP protein degradation; protein stabilization; molecular association, regulation; activity, inhibited; phosphorylation; ubiquitination; intracellular localization; neddylation cell cycle regulation; carcinogenesis, induced; carcinogenesis, altered; carcinogenesis, inhibited; cell growth, inhibited; transcription, induced; signaling pathway regulation; cell differentiation, induced; cell motility, altered; cell adhesion, altered; transcription, inhibited CBLL1(INDUCES); axin 1(INDUCES); TRAF2(DISRUPTS); CDH1(INDUCES); RNF4(INDUCES) 11955436; 12000790; 16618120; 18356165; 19244247; 20419129; 25660024; 27653698; 31462704; 31933784; 32021251; 32041324; 32046730; 33832512; 34117362; 34657130; 35108540; 35320710; 35358275; 35879396; 36808719 57 7 0 -Slc1a2 GLT1 Membrane protein, integral; Membrane protein, multi-pass; Transporter; Transporter, SLC family P31596 29482 3q32 rat K573-ub 1873542800 EEPWKREk_______ receptor internalization, induced; protein degradation 18805448 1 0 0 -E2F1 E2F1 DNA-binding; Transcription factor Q01094 1869 20q11.22 human S364-p 449403 PLLSRMGsLRAPVDE activity, induced; protein degradation; molecular association, regulation; protein stabilization; intracellular localization; enzymatic activity, induced cell cycle regulation; carcinogenesis, induced; cell growth, inhibited; apoptosis, induced; autophagy, inhibited; transcription, induced; signaling pathway regulation Rb(INDUCES) 12717439; 22184068; 33110360; 33174204; 35301407 8 2 0 -CEBPD C/EBP-delta DNA-binding; Motility/polarity/chemotaxis P49716 1052 8q11.21 human S57-p 40263800 PAMYDDEsAIDFSAY enzymatic activity, induced transcription, induced 25680545 1 0 0 activates PPARgamma2 promoter -Stk3 MST2 Autophagy; EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, STE; Protein kinase, Ser/Thr (non-receptor) Q9JI10 56274 15|15 B3.1 mouse Y81-p 25528501 MQQCDSPyVVKYYGS Pkinase molecular association, regulation apoptosis, induced MST2(INDUCES); RAF1(DISRUPTS) 22590567 1 1 0 -CERS4 LASS4 DNA-binding; Membrane protein, integral; Membrane protein, multi-pass Q9HA82 79603 19p13.2 human S349-p 7102761 SDVEESDsSEEAAAA enzymatic activity, induced 26887952 1 7 0 -DEPTOR DEPTOR Apoptosis Q8TB45 64798 8q24.12 human T241-p 4723803 KSPSSQEtHDSPFCL protein degradation; molecular association, regulation carcinogenesis, induced; apoptosis, inhibited; signaling pathway regulation mTOR(DISRUPTS) 19446321 1 4 2 PI3K-Akt signaling -AXIN1 axin 1 Adaptor/scaffold; Tumor suppressor O15169 8312 16p13.3 human S77-p 3174926 YEPEGSAsPTPPYLK AXIN1_TNKS_BD transcription, inhibited GSK3B(INDUCES) 17318175 1 13 9 -CLCN1 CLCN1 Channel, chloride; Membrane protein, integral; Membrane protein, multi-pass; Transporter; Transporter, ion channel P35523 1180 7q34 human T893-p 14645301 SFRNTTStRKSTGAP activity, induced 20511714 1 0 1 -TRAF3 TRAF3 UBIQUITIN LIGASE; Ubiquitin conjugating system; Ubiquitin ligase Q13114 7187 14q32.32 human K168-ub 56836807 DLRDHVEkACKYREA zf-TRAF molecular association, regulation exocytosis, induced RALGDS(INDUCES) 27438768 1 0 0 K33 polyubiquitination of TRAF3 Is necessary for RALGDS binding; exocytosis of bacteria via TLR4-mediated innate immune signaling -Pxn PXN Adaptor/scaffold; Cell adhesion; Cytoskeletal; Motility/polarity/chemotaxis Q8VI36 19303 5 F|5 56.1 cM mouse S83-p 451113 YAHQQPPsPLPVYSS Paxillin activity, induced; molecular association, regulation cell differentiation, altered; cell motility, altered; cytoskeletal reorganization ERK1(INDUCES); FAK iso2(INDUCES) 15494312 7 40 44 -Plcg1 PLCG1 Carbohydrate Metabolism - inositol phosphate; EC 3.1.4.11; Motility/polarity/chemotaxis; Phospholipase P10686 25738 3q42 rat Y509-p 464036 NHEWYPHyFVLTSSK enzymatic activity, inhibited; phosphorylation 20164676 3 0 8 Y509A/F510A mutant PLCG1 has enhanced phosphorylation of Y783, but no longer requires Y783 phosphorylation for enzymatic activation -MAPK11 P38B EC 2.7.11.24; KINASE; Kinase, protein; Protein kinase, CMGC; Protein kinase, Ser/Thr (non-receptor) Q15759 5600 22q13.33 human S261-p 54390601 HARTYIQsLPPMPQK Pkinase enzymatic activity, inhibited 26976637 1 1 0 -NUP98 NUP98 iso2 Motility/polarity/chemotaxis; Nucleoporin P52948-2 4928 11p15.4 human S591-p 470431 VLKNLNNsNLFSPVN intracellular localization 21335236 1 35 2 as multiple sites (13PM) mutant -EEF1D EEF1D Translation; Translation elongation P29692 1936 8q24.3 human S133-p 455672 APQTQHVsPMRQVEP phosphorylation 12551973 2 108 49 -FOXO3 FOXO3A Autophagy; DNA-binding; Oncoprotein; Transcription factor O43524 2309 6q21 human S294-p 472326 QLSKWPGsPTSRSSD protein degradation; molecular association, regulation; activity, inhibited cell growth, altered MDM2(INDUCES) 18204439 5 19 63 promotes tumorigenicity -Med1 MED1 Nuclear receptor co-regulator; Transcription, coactivator/corepressor Q925J9 19014 11 D|11 61.75 cM mouse T1032-p 458308 SSSNRPFtPPTSTGG transcription, induced 18339625 4 8 2 -NEDD8 NEDD8 Ubiquitin-like modifier Q15843 4738 14q12 human K48-ac 461330 QRLIYSGkQMNDEKT ubiquitin molecular association, regulation PARP1(INDUCES) 30804002 1 6 3 -SKP2 SKP2 Cell cycle regulation; UBIQUITIN LIGASE; Ubiquitin conjugating system; Ubiquitin ligase Q13309 6502 5p13.2 human K68-ac 25673101 HPESPPRkRLKSKGS protein stabilization; intracellular localization carcinogenesis, induced; cell motility, induced SKP2(INDUCES) 22770219; 23230084 2 1 0 -Ppara PPAR-alpha DNA-binding; Nuclear receptor; UBIQUITIN LIGASE P37230 25747 7q34 rat S163-p 22342300 CRFHKCLsVGMSHNA zf-C4 intracellular localization transcription, induced 22091731 1 0 0 -Foxo1 FOXO1A DNA-binding; Nuclear receptor co-regulator; Oncoprotein; Transcription factor Q9R1E0 56458 3 C|3 23.19 cM mouse S415-p 478369 NTSLNSPsPNYSKYT molecular association, regulation; intracellular localization transcription, inhibited DUSP6(INDUCES) 22503562; 22848439 4 1 0 -CASQ2 calsequestrin 2 Calcium-binding P12637 483134 dog S397-p 451464 DDDDGNNsDEESNDD intracellular localization 21431367 2 3 0 regulates intracellular trafficking of calsequestrin 2 -Aqp2 AQP2 Channel, misc.; Membrane protein, integral; Membrane protein, multi-pass; Transporter; Transporter, aquaporin family P34080 25386 7q36 rat S269-p 3339002 PQSLPRGsKA_____ intracellular localization endocytosis, inhibited 18843259; 20089674; 22403603; 23559583; 26147297; 30488437; 32113684 37 5 0 -PRKCA PKCA EC 2.7.11.13; KINASE; Kinase, protein; Oncoprotein; Protein kinase, AGC; Protein kinase, Ser/Thr (non-receptor) P17252 5578 17q24.2 human T228-p 3875546 PQWNESFtFKLKPSD C2 molecular association, regulation; enzymatic activity, induced RhoGDI beta(INDUCES) 26414765 1 5 13 -KEAP1 KEAP1 Endoplasmic reticulum; Motility/polarity/chemotaxis; Transcription regulation; UBIQUITIN LIGASE; Ubiquitin conjugating system Q14145 9817 19p13.2 human S599-p 29606702 SEVTRMTsGRSGVGV molecular association, regulation carcinogenesis, inhibited; apoptosis, inhibited NRF2(INDUCES) 24127568 1 1 0 -UNG UNG EC 3.2.2.27; Hydrolase P13051 7374 12q24.11 human S23-p 2018600 ARKRHAPsPEPAVQG activity, induced; molecular association, regulation; enzymatic activity, induced RPA1(INDUCES) DNA(INDUCES) 18079698 1 34 1 -Nr2c1 NR2C1 DNA-binding; Nuclear receptor Q505F1 22025 10 C2|10 48.81 cM mouse S185-p 457682 IEVSREKsSNCAAST molecular association, regulation PCAF(INDUCES) 16317770 1 0 0 this interaction is enhanced by S170 phosphorylation -MITF MITF iso9 DNA-binding; Oncoprotein; Transcription factor O75030-9 4286 3p13 human K316-sm 3590700 DLVNRIIkQEPVLEN DUF3371 transcription, inhibited 15507434 3 1 0 -PLCG2 PLCG2 Carbohydrate Metabolism - inositol phosphate; EC 3.1.4.11; Motility/polarity/chemotaxis; Phospholipase P16885 5336 16q23.3 human Y1197-p 447938 LESEEELySSCRQLR enzymatic activity, induced 30344948 4 1 87 intramolecular tyrosine-phosphorylation and Rac mediated activation -Panx1 PANX1 Cell adhesion; Membrane protein, integral; Membrane protein, multi-pass Q9JIP4 55991 9|9 A2 mouse S205-p 1874115103 YLKTKKNsSHLIMKY Innexin activity, induced 34283971 1 0 0 -SNCA SNCA Adaptor/scaffold P37840 6622 4q22.1 human K21-ub 466355 GVVAAAEkTKQGVAE Synuclein ubiquitination; phosphorylation 16847063 1 1 0 SNCA is phosphorylated, truncated, and then deposited to Lewy bodies.and then ubiquitinated which occurs at K12, K21. and K23 -Glra3 GLRA3 Membrane protein, integral; Membrane protein, multi-pass; Transporter; Transporter, ion channel Q91XP5 110304 8 B2|8 29.69 cM mouse S379-p 1848000 TDDEVREsRFSFTAY Neur_chan_memb receptor desensitization, altered; activity, inhibited 17997221 2 0 0 -RPAP3 RPAP3 Unknown function Q9H6T3 79657 12q13.11 human S119-p 1279822 HESLSQEsESEEDGI molecular association, regulation 35129352 1 26 9 inhibits binding to ribosomal proteins and biogenesis factors associated with small (40S) and large (60S) subunits of the ribosome -H3C14 HIST2H3A/C/D DNA-binding Q71DI3 126961 1q21.2 human S10-p 18465104 TKQTARKsTGGKAPR Histone chromatin organization, altered; transcription, induced 20075197 1 2 0 -AKT1 Akt1 EC 2.7.11.1; KINASE; Kinase, protein; Oncoprotein; Protein kinase, AGC; Protein kinase, Ser/Thr (non-receptor) P31749 207 14q32.33 human K284-ub 964497186 LENLMLDkDGHIKIT Pkinase protein degradation; molecular association, regulation autophagy, induced GRP78(INDUCES) 32164484 2 1 0 HSPA5 arginylation, modulated by ATE1 -FOXL2 FOXL2 DNA-binding; Transcription factor P58012 668 3q22.3 human K25-sm 10304922 PETGRTVkEPEGPPP transcription, inhibited 19744555 1 0 0 -NDUFS2 NDUFS2 EC 1.6.5.3; EC 1.6.99.3; Energy Metabolism - oxidative phosphorylation; Mitochondrial; Oxidoreductase O75306 4720 1q23.3 human S364-p 33402201 KVDDAKVsPPKRAEM Complex1_49kDa activity, induced cell cycle regulation 24746669 1 1 0 increases mitochondrial respiration for G/2M transition -Ppp1r12a MYPT1 Motility/polarity/chemotaxis; PHOSPHATASE; Protein phosphatase, regulatory subunit Q9DBR7 17931 10 D1|10 56.33 cM mouse S909-p 1983104 SLLGRSAsYSYLEDR molecular association, regulation 14-3-3 zeta(INDUCES) 26702834 3 43 60 -Esrra ERR1 DNA-binding; Nuclear receptor; Transcription regulation O08580 26379 19 A|19 5.08 cM mouse K402-sm 487494 LAHFYGVkLEGKVPM Hormone_recep transcription, inhibited 18063693 2 1 0 -PRKDC DNAPK DNA repair, damage; EC 2.7.11.1; KINASE; Kinase, protein; Nucleolus; Protein kinase, Ser/Thr (non-receptor); Protein kinase, atypical P78527 5591 8q11.21 human T2620-p 473574 QGTLQTRtQEGSLSA DNAPKcs_CC5 molecular association, regulation; protein conformation DNA repair, induced DNA(DISRUPTS) 24687855 2 4 17 cell survival induced, induces removal of cisplatin adducts from DNA, induces end processing -ERBB4 HER4 EC 2.7.10.1; KINASE; Kinase, protein; Membrane protein, integral; Protein kinase, TK; Protein kinase, tyrosine (receptor) Q15303 2066 2q34 human Y1081-p 4825103 EQGVSVPyRAPTSTI molecular association, regulation Arg(INDUCES); CRK(INDUCES) 18721752 0 1 0 -Bcl11b Bcl-11B C2H2-type zinc finger protein; Nuclear receptor co-regulator; Transcription regulation Q99PV8 58208 12 F1|12 59.1 cM mouse T260-p 3828640 GPASTSLtPRLTIPP molecular association, regulation SENP1(INDUCES) 22700985 0 6 52 -TWIST1 TWIST1 Cell development/differentiation; DNA-binding; Inhibitor; Transcription regulation Q15672 7291 7p21.1 human K33-me 1883454506 RQQPPSGkRGGRKRR cell motility, induced; transcription, inhibited; cell adhesion, inhibited 35694846 1 1 0 methylation of TWIST1 at K33 represses the expression of LINC-PINT by increasing H3K27me3 repressive mark at the LINC-PINT locus -SNCA SNCA Adaptor/scaffold P37840 6622 4q22.1 human K58-ub 1877722302 GVATVAEkTKEQVTN Synuclein protein degradation; ubiquitination 31167929 1 1 0 ubiquitination and degradation of internalized SNCA fibrils -ZNF322 ZNF322A C2H2-type zinc finger protein; Transcription factor Q6U7Q0 79692 6p22.2 human S224-p 114810402 EKSYRHRsAFIVHKR zf-C2H2 activity, induced; molecular association, regulation carcinogenesis, induced; chromatin organization, altered; cell motility, induced; cell growth, induced; transcription, induced DNA(INDUCES) 31399647 2 1 0 chromatin binding; increases recruitment to ADD1 and CCND1 promoters -NEDD1 NEDD1 Cell cycle regulation Q8NHV4 121441 12q23.1 human S558-p 25533010 PNPKIASsVTAGVAS molecular association, regulation cytoskeletal reorganization TUBG1(INDUCES) 22595525 1 1 0 regulates spindle assembly in mitosis; Negative effect on NEDD1 function -ARID5B Mrf-2 Q14865 84159 10q21.2 human K336-m2 20936502 YKYMKERkTPIERIP ARID molecular association, regulation transcription, induced Mrf-2(INDUCES) DNA(INDUCES) 21532585 1 0 0 demethylation of Mrf-2 K336, complex is then targeted to promoters and removes repressive H3K9m2 -RPS6KA6 RSK4 EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, AGC; Protein kinase, Ser/Thr (non-receptor) Q9UK32 27330 Xq21.1 human S232-p 457600 DQEKKAYsFCGTVEY Pkinase protein conformation; enzymatic activity, induced carcinogenesis, induced; cell motility, induced 15632195; 34261798 2 40 151 -STX17 STX17 Membrane protein, integral; Membrane protein, multi-pass; Vesicle P56962 55014 9q31.1 human S2-p 50800659 ______MsEDEEKVK molecular association, regulation autophagy, inhibited; signaling pathway regulation VPS33A(INDUCES); VAMP7(DISRUPTS); SNAP29(DISRUPTS) 30655294 1 1 0 -KIF2C KIF2C Cancer Testis Antigen (CTA); Microtubule-binding; Motility/polarity/chemotaxis; Motor Q99661 11004 1p34.1 human S115-p 2132104 RSRSTRMsTVSELRI intracellular localization; activity, inhibited cytoskeletal reorganization 14960279 1 8 8 -Ctnnb1 CTNNB1 Actin-binding; Cell adhesion; Motility/polarity/chemotaxis; Nuclear receptor co-regulator; Oncoprotein; Transcription factor Q02248 12387 9 F4|9 72.19 cM mouse Y654-p 447585 RNEGVATyAAAVLFR activity, induced; molecular association, regulation; intracellular localization carcinogenesis, induced; cell motility, altered; transcription, induced; cell adhesion, altered; cytoskeletal reorganization; transcription, altered TCF4(INDUCES); TBP(INDUCES); CDH2(DISRUPTS); CDH1(DISRUPTS); SMAD2(INDUCES) 10593980; 11279024; 19104148; 19336574; 22203675; 28821617; 33929542; 37029299 32 2 20 -CCNY CBCP1 Cell cycle regulation Q8ND76 219771 10p11.21 human S73-p 3850500 STIFLSKsQTDVREK protein degradation; ubiquitination 24794231 1 19 49 -Gab2 GAB2 Adaptor/scaffold Q9Z1S8 14389 7|7 E1 mouse S620-p 15410336 PSPHRKPsTSSVTSD molecular association, regulation; phosphorylation cell motility, inhibited; signaling pathway regulation SHP-2(DISRUPTS) 23401857 1 1 2 inhibits ERK1/2 phosphorylation, modulates Ras/MAPK signaling pathway -ARHGEF7 ARHGEF7 iso1 GEF; GEF, Rac/Rho; Motility/polarity/chemotaxis Q14155-1 8874 13q34 human S340-p 454356 LSASPRMsGFIYQGK PH activity, induced; molecular association, regulation RAC1(INDUCES) 24792722 2 102 7 O2 production increased, Nox1 activity upregulated -HMGB1 HMGB1 DNA repair, damage; Nuclear receptor co-regulator P09429 3146 13q12.3 human S39-p 7320388 PDASVNFsEFSKKCS HMG_box_2 intracellular localization cell motility, altered 19506549; 22750245; 23782844 4 5 2 increases tumor cell invasiveness -Rps6kb1 p70S6K EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, AGC; Protein kinase, Ser/Thr (non-receptor); Translation Q8BSK8 72508 11|11 C mouse T412-p 448607 NQVFLGFtYVAPSVL Pkinase_C molecular association, regulation; ubiquitination; enzymatic activity, induced cell cycle regulation; carcinogenesis, induced; carcinogenesis, inhibited; apoptosis, induced; translation, induced; signaling pathway regulation DEDD(INDUCES) 17562705; 18851840; 19106089; 20657550; 25119572; 25680463; 33567340; 33826903; 33876772; 34531315; 34664403; 36012713 476 9 1 -SCN5A SCN5A Channel, sodium; Membrane protein, integral; Membrane protein, multi-pass Q14524 6331 3p22.2 human S571-p 27281507 PWPLRRTsAQGQPSP Na_trans_cytopl activity, induced; intracellular localization; enzymatic activity, induced 30385719; 31622781 10 4 0 Induce and regulate Atrial fibrillation, increase calcium mediated arrhythmia and regulates atrial myocyte late Na current and membrane excitability; triggered Ca2+ waves -LCK Lck EC 2.7.10.2; KINASE; Kinase, protein; Oncoprotein; Protein kinase, TK; Protein kinase, tyrosine (non-receptor) P06239 3932 1p35.2 human S59-p 447820 EGSNPPAsPLQDNLV molecular association, regulation; enzymatic activity, inhibited cell adhesion, inhibited SQSTM1(INDUCES) 27941787; 7597029; 8618896 10 2 7 -MALT1 MALT1 Adaptor/scaffold; Apoptosis; EC 3.4.22.-; Ligase; Nuclear export; Protease; UBIQUITIN LIGASE; Ubiquitin conjugating system Q9UDY8 10892 18q21.32 human K702-ub 2134709 LEDTVEDkQEVNVGK MALT1_Ig protein degradation; molecular association, regulation IKKA(INDUCES) 17948050 1 0 0 activation of NF-kB pathway and IL-2 induction -Fos Fos DNA-binding; Motility/polarity/chemotaxis; Oncoprotein; Transcription factor P01101 14281 12 D2|12 39.7 cM mouse S362-p 448481 AAAHRKGsSSNEPSS activity, induced; molecular association, regulation; protein stabilization carcinogenesis, induced; transcription, altered; signaling pathway regulation ER-beta(INDUCES) 15719069; 21119595; 21565615 10 3 1 c-FOS transcription inhibited -IKBKG IKKG Adaptor/scaffold; Protein kinase, regulatory subunit Q9Y6K9 8517 Xq28 human K285-ub 486356 QEVIDKLkEEAEQHK CC2-LZ activity, induced; ubiquitination apoptosis, inhibited; transcription, induced; signaling pathway regulation 15620648; 17728323; 19136968; 20932475; 21811235; 23453807; 23871670 7 7 12 regulates NF-kB ignaling and mitochondrial integrity; Loss of LUBAC impaired TNF mediated NF-kB activation, HOIL-1 deficiency (ubiquitylation) enhances apoptosis; activation of TAK1 IKK and NF-kB after genotoxic stress; K-R mutants cause embryonic lethality, complemented by TNFR1 loss, regulates NF-kB activation and NOD2 signaling in response to innate immune agonists -TRDMT1 TRDMT1 Amino Acid Metabolism - cysteine and methionine; EC 2.1.1.204; METHYLTRANSFERASE; Methyltransferase; Methyltransferase, tRNA O14717 1787 10p13 human K251-ub 1881202800 QDSDLSVkMLKDFLE DNA repair, inhibited 33778494 1 1 0 role in removing TRDMT1 from DNA damage sites after completion of repair -Gsk3a GSK3A EC 2.7.11.1; EC 2.7.11.26; KINASE; Kinase, protein; Protein kinase, CMGC; Protein kinase, Ser/Thr (non-receptor) Q2NL51 606496 7|7 A3 mouse S21-p 448584 SGRARTSsFAEPGGG protein degradation; enzymatic activity, inhibited; phosphorylation cell motility, induced; apoptosis, induced; cell adhesion, inhibited; transcription, altered; signaling pathway regulation; cytoskeletal reorganization; cell growth, altered; endocytosis, inhibited 15033922; 15791206; 18851840; 19106302; 22172670; 34638997; 36445308 156 24 277 inhibits DYN2 phosphorylation; regulate platelet activation -Srebf1 SREBP-1 iso1 DNA-binding; Membrane protein, integral; Membrane protein, multi-pass; Transcription factor P56720-1 78968 10q22 rat S308-p 458357 IEKRYRSsINDKIVE HLH sumoylation; protein degradation; ubiquitination transcription, inhibited 24379443; 24853806 4 1 0 -Enah Mena iso4 Adaptor/scaffold; Motility/polarity/chemotaxis Q03173-4 13800 1 H5|1 84.93 cM mouse S236-p 451465 WERERRMsNAAPSSD cell motility, altered; cytoskeletal reorganization; cell growth, altered 12134088; 15066263 3 2 15 -TTK TTK Cancer Testis Antigen (CTA); EC 2.7.12.1; KINASE; Kinase, protein; Protein kinase, Other; Protein kinase, dual-specificity (non-receptor) P33981 7272 6q14.1 human K367-sm 52485002 TESSLLAkLEETKEY molecular association, regulation cell cycle regulation BUB1B(DISRUPTS) 26675261 1 1 0 -WASF3 WASF3 Actin-binding; Motility/polarity/chemotaxis Q9UPY6 10810 13q12.13 human Y151-p 486448 KKDGLKFyTDPSYFF cell motility, induced; cytoskeletal reorganization 17623672 1 0 0 induces lamellipodia formation -Akt1 Akt1 EC 2.7.11.1; KINASE; Kinase, protein; Oncoprotein; Protein kinase, AGC; Protein kinase, Ser/Thr (non-receptor) P47196 24185 6q32 rat S473-p 447855 RPHFPQFsYSASGTA Pkinase_C activity, induced; molecular association, regulation; intracellular localization; protein conformation; phosphorylation; enzymatic activity, induced cell cycle regulation; cell differentiation, altered; autophagy, induced; cell growth, induced; cell adhesion, induced; apoptosis, inhibited; signaling pathway regulation RAF1(INDUCES) 11027222; 11042116; 11443134; 11517188; 14627993; 15665834; 15853465; 16829026; 17079231; 18838385; 19757038; 20096547; 21736902; 21949366; 22031698; 22046442; 22228770; 33864097; 34057658; 34221817; 34335915; 34475824; 34577062; 35562960; 37237886 1956 25 44 -App APP Apoptosis; Cell surface; Membrane protein, integral; Receptor, misc.; Transcription factor P08592 54226 11q11 rat T743-p 448523 VEVDAAVtPEERHLS APP_amyloid protein degradation 14557249 39 5 3 T743 phosphorylation directly impacts on APP cleavage -OTUD6A OTUD6A DEUBIQUITINASE; EC 3.4.19.12; Ubiquitin-specific protease Q7L8S5 139562 Xq13.1 human S71-p 40512705 EKFQDDSsIESVVED molecular association, regulation; intracellular localization cell cycle regulation; carcinogenesis, induced TOPBP1(DISRUPTS) 35768646 1 3 0 -DYNLL1 LC8 Microtubule-binding; Motility/polarity/chemotaxis; Motor P63167 8655 12q24.31 human S88-p 454241 VAILLFKsG______ Dynein_light molecular association, regulation; protein conformation; phosphorylation cell cycle regulation; cell differentiation, altered; apoptosis, altered; apoptosis, inhibited; cell growth, altered LC8(DISRUPTS); PAK1(DISRUPTS); MRE11A(INDUCES); 53BP1(DISRUPTS); BLM(INDUCES); NBS1(INDUCES); DNA2(INDUCES); RAD50(INDUCES); BIM(DISRUPTS) 15193260; 18084006; 18650427; 19289209; 19863079; 21062069; 23038268; 30464262 9 0 0 -RPS3 RPS3 Apoptosis; EC 4.2.99.18; RNA-binding; Ribosomal; Translation P23396 6188 11q13.4 human K230-sm 25218901 ISEQKGGkPEPPAMP protein stabilization 21968017 1 3 0 -PUM3 PUM3 Endoplasmic reticulum; Nucleolus; RNA-binding Q15397 9933 9p24.2 human Y259-p 463700 SAIVEYAyNDKAILE protein stabilization; ubiquitination; intracellular localization carcinogenesis, induced; cell growth, induced 34407138 1 5 70 inhibits ubiquitination -CGAS cGAS EC 2.7.7.86 Q8N884 115004 6q13 human K384-ac 14366387 LSFSHIEkEILNNHG Mab-21 enzymatic activity, inhibited; protein conformation; activity, inhibited apoptosis, inhibited 30799039; 32345711; 33438687 3 3 0 -JAK1 JAK1 EC 2.7.10.2; KINASE; Kinase, protein; Protein kinase, TK; Protein kinase, tyrosine (non-receptor) P23458 3716 1p31.3 human Y1034-p 448451 AIETDKEyYTVKDDR PK_Tyr_Ser-Thr enzymatic activity, induced carcinogenesis, induced; cell motility, induced 32029900; 34380633; 36166512 33 12 178 -FXYD1 PLM Cell surface; Channel, misc.; Membrane protein, integral P56513 476487 dog S88-p 451425 RSSIRRLsTRRR___ activity, induced 15653756; 17991751 27 3 74 increases Na(+) affinity of ATP1A1/B1; regulation of cardiac contractility -H1-4 H1E DNA-binding P10412 3008 6p22.2 human K26-m3 6742809 PVKKKARkSAGAAKR cell cycle regulation 24873882 2 1 0 -LMNB1 Lamin B1 Cytoskeletal P20700 4001 5q23.2 human K134-ac 33363078 DLNGAQIkLREYEAA Filament protein stabilization cell cycle regulation; DNA repair, inhibited 33533922 1 3 0 K134 acetylation may stabilize LMNB1, maintaining nuclear periphery integrity during viral infections, impacts G1 to S phase cell cycle transition, reduces laminar association with chromatin, delays recruitment of cNHEJ repair factor 53BP1 to DNA repair foci -AIP AIP Nuclear receptor co-regulator; Transcription, coactivator/corepressor O00170 9049 11q13.2 human S53-p 10888703 EGTVLDDsRARGKPM FKBP_C intracellular localization 12361709 1 0 0 -SHC1 SHC1 Adaptor/scaffold; Apoptosis; Mitochondrial; Motility/polarity/chemotaxis P29353 6464 1q21.3 human Y349-p 448509 EEPPDHQyYNDFPGK molecular association, regulation apoptosis, altered; apoptosis, inhibited GRB2(INDUCES) 15688026; 8939605; 8947042 32 22 947 -CYLD CYLD DEUBIQUITINASE; EC 3.4.19.12; Protease; Tumor suppressor; Ubiquitin conjugating system; Ubiquitin-specific protease Q9NQC7 1540 16q12.1 human S362-p 31957307 FYTLNGSsVDSQPQS CYLD_phos_site enzymatic activity, induced 24614225 1 1 0 -PRRG4 PRRG4 Membrane protein, integral Q9BZD6 79056 11p13 human Y207-p 1870790706 SVSPPPPyPGHTKGF molecular association, regulation; phosphorylation carcinogenesis, induced; cell motility, induced Src(INDUCES); NEDD4(INDUCES) 33037408 1 0 0 FAK phosphorylation -RRAD RRAD G protein; G protein, monomeric; G protein, monomeric, RGK P55042 6236 16q22.1 human S290-p 457397 GRIVARNsRKMAFRA molecular association, regulation Calmodulin(INDUCES) 9677319 1 1 0 -CALD1 Caldesmon Actin-binding P12957 373965 chicken S602-p 457430 CFSPKGSsLKIEERA Caldesmon molecular association, regulation ACTB(NOT_REPORTED) 8182108 2 9 0 -CDX2 CDX2 DNA-binding; Transcription factor Q99626 1045 13q12.2 human S283-p 456208 RSVPEPLsPVSSLQA protein degradation 16027724 1 1 0 -MRE11 MRE11A Cell cycle regulation; DNA repair, damage; DNA-binding; Deoxyribonuclease P49959 4361 11q21 human R577-me 2344808 RGRGRGRrGGRGQNS intracellular localization 15970667 1 0 0 localizes in nucleus and associates with nuclear bodies and sites of DNA damage -CDK1 CDK1 Cell cycle regulation; EC 2.7.11.22; EC 2.7.11.23; KINASE; Kinase, protein; Motility/polarity/chemotaxis; Protein kinase, CMGC; Protein kinase, Ser/Thr (non-receptor) P06493 983 10q21.2 human T161-p 447609 GIPIRVYtHEVVTLW Pkinase molecular association, regulation; intracellular localization; enzymatic activity, induced cell cycle regulation; carcinogenesis, induced; apoptosis, induced; cell growth, induced; cell growth, altered CCNB1(INDUCES); CCNA2(INDUCES) 12663041; 1532335; 1833185; 21900495; 25849598; 31429764; 33574676; 34064109; 34370741; 35392228; 36163549; 36967563; 8441405 44 43 83 -Stx3 STX3 Cell adhesion; Membrane protein, integral; Vesicle Q08849 81802 1q43 rat T14-p 31960301 QLKAKQLtQDDDTDE molecular association, regulation; protein conformation exocytosis, inhibited STXBP2(DISRUPTS) 26936588 5 1 0 degranulation decreased -PRKCD PKCD EC 2.7.11.13; KINASE; Kinase, protein; Nuclear receptor co-regulator; Protein kinase, AGC; Protein kinase, Ser/Thr (non-receptor); Protein kinase, tyrosine (non-receptor); Tumor suppressor Q05655 5580 3p21.1 human Y52-p 447574 VQKKPTMyPEWKSTF activity, inhibited apoptosis, altered 11927579 4 0 0 -Msn Moesin Cytoskeletal; Motility/polarity/chemotaxis P26041 17698 X|X C3 mouse T558-p 447706 LGRDKYKtLRQIRQG ERM_C molecular association, regulation; intracellular localization cell motility, altered; cytoskeletal reorganization Moesin(INDUCES) 19255442; 19890007; 24250818; 9456324; 9856983 40 8 29 iincreased filopodia with phosphorylated ERM proteins -Abl2 Arg EC 2.7.10.2; KINASE; Kinase, protein; Oncoprotein; Protein kinase, TK; Protein kinase, tyrosine (non-receptor) Q4JIM5 11352 1 G3|1 67.71 cM mouse Y272-p 456540 KCNKPTVyGVSPIHD enzymatic activity, induced 12748290 3 5 3 -GIT1 GIT1 iso3 GAP; GAP, ARF; Motility/polarity/chemotaxis Q9Y2X7-3 28964 17q11.2 human T765-p 1868139202 KQLVTITtREKKQ__ GIT1_C molecular association, regulation liprin alpha 1(DISRUPTS); PXN(INDUCES) 30737283 1 0 0 -SCN5A SCN5A Channel, sodium; Membrane protein, integral; Membrane protein, multi-pass Q14524 6331 3p22.2 human T486-p 7835300 RKRMSSGtEECGEDR protein conformation 33410863 2 4 2 -CHEK2 Chk2 EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, CAMK; Protein kinase, Ser/Thr (non-receptor); Tumor suppressor O96017 11200 22q12.1 human S19-p 447546 SHGSSACsQPHGSVT molecular association, regulation; enzymatic activity, induced cell cycle regulation Chk2(INDUCES) 16940182 12 1 0 S19A mutant shows impaired dimerization and does not promote Hdmx degradation -MAPT Tau iso8 ACETYLTRANSFERASE; Acetyltransferase; Cytoskeletal P10636-8 4137 17q21.31 human K321-ac 490850600 DLSKVTSkCGSLGNI Tubulin-binding molecular association, regulation; acetylation; protein conformation cytoskeletal reorganization 28760828; 34426645 2 1 0 impedes tau filament assembly ; acetylation mimetics are aggregation resistant, inhibit prion-like seeded P301L mutation aggregation, alter conformation of P301L/S320F aggregation; reduced tau microtuble interactions -ALYREF THOC4 Chaperone; RNA-binding; Spliceosome; Transcription, coactivator/corepressor Q86V81 10189 17q25.3 human T219-p 4614100 GGGTRRGtRGGARGR FoP_duplication activity, induced cell growth, altered 18562279 1 1 0 required for THOC4 mRNA export activity -ADORA2A ADORA2A GPCR, family 1; Membrane protein, integral; Membrane protein, multi-pass; Receptor, GPCR P11617 403960 dog T298-p 451126 RIREFRQtFRKIIRS receptor desensitization, altered 9020781 1 0 0 The integrity of T298 is essential for short-term but not long-term desensitization of A2aAR function. -CYSLTR1 CYSLTR1 GPCR, family 1; Membrane protein, integral; Membrane protein, multi-pass; Receptor, GPCR Q9Y271 10800 Xq21.1 human S313-p 11143517 LSTFRKHsLSSVTYV receptor desensitization, induced transcription, induced 22230957 1 3 3 -Smad1 SMAD1 DNA-binding; Transcription factor P97588 25671 19q11 rat S466-p 448362 SPHNPISsVS_____ cell growth, induced; signaling pathway regulation 21445358 12 13 58 Src/SMAD1 signaling pathway -Ctnnb1 CTNNB1 Actin-binding; Cell adhesion; Motility/polarity/chemotaxis; Nuclear receptor co-regulator; Oncoprotein; Transcription factor Q9WU82 84353 8q32 rat Y142-p 449044 AVVNLINyQDDAELA intracellular localization 33660049 16 2 0 regulates dissociation of adherent junctions -HSD17B10 HADH2 Amino Acid Metabolism - valine, leucine and isoleucine degradation; EC 1.1.1.178; EC 1.1.1.35; EC 1.1.1.51; Mitochondrial; Oxidoreductase Q99714 3028 Xp11.22 human K79-ac 33345847 QTALALAkGKFGRVD adh_short enzymatic activity, inhibited cell growth, inhibited RG9MTD1(DISRUPTS) 32703935; 32956445 2 3 0 formation of mt-tRNA splicing complex, regulated mitochondrial function, les cell resistance to stress and cell growth ; mt-tRNA splicing complex -RB1 Rb Nuclear receptor co-regulator; Oncoprotein; Transcription, coactivator/corepressor; Tumor suppressor P06400 5925 13q14.2 human S795-p 447979 SPYKFPSsPLRIPGG Rb_C molecular association, regulation; activity, inhibited cell cycle regulation; carcinogenesis, induced; cell growth, induced; cell growth, altered ARF1(DISRUPTS); E2F1(DISRUPTS); TFDP1(DISRUPTS) 14676836; 15028555; 15619620; 16007177; 16360038; 21478909; 33931028; 9190208; 9315635 52 17 94 -Sirt7 SIRT7 DEACETYLASE; Deacetylase; EC 3.5.1.-; Nucleolus Q8BKJ9 209011 11|11 E2 mouse T256-p 1874512902 PLNWEAAtEAASKAD SIR2 protein stabilization; molecular association, regulation; ubiquitination; phosphorylation carcinogenesis, inhibited; cell motility, inhibited; transcription, inhibited; signaling pathway regulation UBR5(DISRUPTS); SKP2(INDUCES) 34433808 1 0 0 inhibits ubiquitination of itself, inhibits AKT phosphorylation and PI3K/AKT pathway -CAMK2A CAMK2A iso2 EC 2.7.11.17; KINASE; Kinase, protein; Protein kinase, CAMK; Protein kinase, Ser/Thr (non-receptor) Q9UQM7-2 815 5q32 human S332-p 3143902 DGVKKRKsSSSVQLM intracellular localization 9677407 3 1 0 blocks nuclear localization -H3-3A H3F3A DNA-binding P84243 3020 1q42.12 human S28-p 18545302 ATKAARKsAPSTGGV Histone phosphorylation 16185088 4 12 0 detecting S10 phosphorylation with phospho-antibody was disrupted in dual modified peptides with K9ac and K9 monomethyl as was S28 with K27ac -DNER DNER Membrane protein, integral; Receptor, misc. Q8NFT8 92737 2q36.3 human Y677-p 473321 QGSSRPAyEEFYNCR DNER_C intracellular localization 18474614 1 1 4 -Ptpro PTPRO EC 3.1.3.48; Membrane protein, integral; Motility/polarity/chemotaxis; PHOSPHATASE; Receptor protein phosphatase, tyrosine E9Q612 19277 6|6 G1 mouse Y1220-p 14312604 FCISDVIyENVSKS_ molecular association, regulation; phosphorylation cytoskeletal reorganization; signaling pathway regulation GRB2(INDUCES); Fyn(INDUCES) 20398064; 30622194 2 2 2 ; Y399F mutation reduces PRPRO ability to dephosphorylate Src Y527 -HAUS8 HAUS8 Cell cycle regulation Q9BT25 93323 19p13.11 human S19-p 20583302 PATGPTNsSSAKKKD molecular association, regulation; intracellular localization cell cycle regulation; cytoskeletal reorganization 21705324 2 1 0 disrupts microtubule binding -NFKBIA IkB-alpha DNA-binding; Inhibitor P25963 4792 14q13.2 human T291-p 451526 EDEESYDtESEFTEF protein degradation; intracellular localization carcinogenesis, induced 37377974; 8657113 5 0 0 regulates p65 nuclear translocation; S283/T291/T299A triple mutant showed increased IkB-alpha stability. -RAB7A Rab7 G protein; G protein, monomeric; G protein, monomeric, Rab P51149 7879 3q21.3 human S72-p 468547 AGQERFQsLGVAFYR Ras molecular association, regulation; intracellular localization; phosphorylation; enzymatic activity, induced autophagy, induced; endocytosis, inhibited CCZ1(DISRUPTS); GDI1(DISRUPTS) 26869029; 36344490; 36408770 7 50 21 induces mitophagy; induces ERK1/2 and P38 phosphorylation and activation, inhibits EGFR degradation -NLRP3 NLRP3 Inhibitor Q96P20 114548 1q44 human S198-p 230295300 GKTKTCEsPVSPIKM FISNA activity, induced; molecular association, regulation; ubiquitination; protein conformation ASCC1(INDUCES) 28943315 5 2 0 deubiquitination; assembly of NLRP3 oligomers; inflammasome activation -IGFBP1 IGFBP1 Secreted; Secreted, signal peptide P08833 3484 7p12.3 human S123-p 4668105 AEAGSPEsPESTEIT molecular association, regulation; activity, inhibited signaling pathway regulation IGF1(INDUCES); CK2B(INDUCES) 20143870; 32502935 7 8 0 regulates mTOR and AAR signaling -Gjb3 GJB3 Channel, misc.; Membrane protein, integral; Membrane protein, multi-pass P28231 14620 4 D2.2|4 61.48 cM mouse S266-p 2907500 KLQASAPsLTPI___ activity, induced; protein stabilization 15023533 1 1 0 -Lmna lamin A/C Cytoskeletal P48678 16905 3 F1|3 38.84 cM mouse S404-p 478681 RSRGRASsHSSQSQG protein degradation; intracellular localization cell differentiation, induced; cytoskeletal reorganization 33462407 8 49 106 -SRC Src EC 2.7.10.2; KINASE; Kinase, protein; Oncoprotein; Protein kinase, TK; Protein kinase, tyrosine (non-receptor) P12931 6714 20q11.23 human S43-p 31885161 QTPSKPAsADGHRGP phosphorylation; enzymatic activity, induced 33388549 2 1 0 induces phosphorylation at Y419 -IRF4 IRF4 DNA-binding; Oncoprotein; Transcription factor Q15306 3662 6p25.3 human K103-ac 6215734 RLRCALNkSNDFEEL IRF intracellular localization apoptosis, induced; transcription, inhibited 34793338 1 1 1 impaired IRF4 nuclear localization -Foxo1 FOXO1A DNA-binding; Nuclear receptor co-regulator; Oncoprotein; Transcription factor G3V7R4 84482 2q26 rat S250-p 448075 SPRRRAAsMDNNSKF protein degradation; ubiquitination; intracellular localization apoptosis, induced; signaling pathway regulation 34057658 98 8 48 regulates PHLPP1/FoxO1?Mdm2 pathway -NRL NRL DNA-binding; Transcription factor P54845 4901 14q11.2-q12 human S50-p 478419 PYSSVPPsPTFSEPG activity, inhibited transcription, altered 17335001 2 0 1 -SSH1 SSH1 EC 3.1.3.16; EC 3.1.3.48; PHOSPHATASE; Protein phosphatase, dual-specificity Q8WYL5 54434 12q24.11 human T826-p 35524905 AGLVRKHtKELERLK phosphorylation 25100728 1 0 0 induce coflin dephosphorylation -CHEK2 Chk2 EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, CAMK; Protein kinase, Ser/Thr (non-receptor); Tumor suppressor O96017 11200 22q12.1 human T205-p 12473001 VFVFFDLtVDDQSVY enzymatic activity, inhibited cell cycle regulation 20126263 1 1 0 mutation of this site impairs checkpoint recovery -ARL4D ARL4D G protein; G protein, monomeric; G protein, monomeric, ARF; Nucleolus P49703 379 17q21.31 human S144-p 23083814 QDQPGALsAAEVEKR Arf protein stabilization; molecular association, regulation; ubiquitination; intracellular localization cell motility, induced HYPK(INDUCES) 35857868 1 1 1 inhibits ubiquitination -PDCD1 PD-1 Apoptosis; Membrane protein, integral Q15116 5133 2q37.3 human S261-p 1881448300 PSGMGTSsPARRGSA protein degradation; ubiquitination; intracellular localization carcinogenesis, inhibited; cell growth, inhibited; apoptosis, induced FBXW7(INDUCES); KPNA2(INDUCES) 36104103 1 0 0 -AR AR DNA-binding; Nuclear receptor; Transcription factor P10275 367 Xq12 human S651-p 448414 GEASSTTsPTEETTQ intracellular localization transcription, altered 16282370; 30644418; 7565807 11 4 0 -PIN1 PIN1 EC 5.2.1.8; Isomerase; Nuclear receptor co-regulator Q13526 5300 19p13.2 human S16-p 447772 PGWEKRMsRSSGRVY WW protein degradation; molecular association, regulation; ubiquitination; intracellular localization; phosphorylation cell cycle regulation BORA(DISRUPTS); PPP1R2(INDUCES) 11723108; 18062707; 22158035; 23090969; 23970419 12 2 0 -TET2 TET2 EC 1.14.11.n2; Oxidoreductase; Tumor suppressor Q6N021 54790 4q24 human S99-p 3202572 GGIKRTVsEPSLSGL molecular association, regulation; protein stabilization carcinogenesis, inhibited; signaling pathway regulation 14-3-3 beta(INDUCES); 14-3-3 theta(INDUCES); 14-3-3 zeta(INDUCES); 14-3-3 epsilon(INDUCES); 14-3-3 eta(INDUCES) 30022161; 31901078 3 17 5 Glucose-AMPK-TET2-5hmc pathway -CSF1R CSFR EC 2.7.10.1; KINASE; Kinase, protein; Membrane protein, integral; Oncoprotein; Protein kinase, TK; Protein kinase, tyrosine (receptor) P07333 1436 5q32 human Y546-p 2866400 KYKQKPKyQVRWKII molecular association, regulation 8798707 4 0 0 binds to an unidentfied 55 KD phosphorylated protein in vitro. -H2AC11 H2A.1 DNA-binding P0C0S8 8329 6p22.1 human R29-m2 22267604 GLQFPVGrVHRLLRK Histone transcription, inhibited 21774791 1 1 0 -Card11 CARD11 Adaptor/scaffold Q8CIS0 108723 5|5 G2 mouse S577-p 457641 AEPPGNDsIVRRCKE enzymatic activity, induced signaling pathway regulation 31391255 3 1 0 antigen receptor signaling -EZR Ezrin Cytoskeletal; Motility/polarity/chemotaxis P15311 7430 6q25.3 human Y191-p 1783300 KDNAMLEyLKIAQDL FERM_M molecular association, regulation; phosphorylation Src(INDUCES) 15647376 2 2 2 -Arhgef6 ARHGEF6 GEF; GEF, Rac/Rho; Motility/polarity/chemotaxis Q8K4I3 73341 X|X A6 mouse S13-p 50175132 RLVTWLIsLGVLESP CH molecular association, regulation; enzymatic activity, induced cell cycle regulation; carcinogenesis, induced; cell motility, induced; cell growth, induced; signaling pathway regulation kindlin-2(INDUCES) 34321603 1 1 0 induces Rac 1 activity and MAPK signaling -Zc3h12a MCPIP1 EC 3.1.-.-; Hydrolase Q5D1E7 230738 4|4 D2.2 mouse S513-p 34505699 YPSREYWsEPYPLPP protein degradation; protein stabilization; molecular association, regulation; intracellular localization RNA stability, induced 14-3-3 beta(INDUCES); MCPIP1(DISRUPTS) RNA(DISRUPTS) 31072819; 34636324 2 4 0 -Pde6g PDE6G EC 3.1.4.35; Nucleotide Metabolism - purine; Phosphodiesterase P09174 18588 11 E2|11 84.14 cM mouse T22-p 449334 RVIGGPVtPRKGPPK PDE6_gamma enzymatic activity, induced; phosphorylation 12624098; 17138607 5 1 5 decreases phospho-ERK; regulates rod light response -Ctbp1 CTBP1 Cell cycle regulation; EC 1.1.1.-; Nuclear receptor co-regulator; Oxidoreductase; Transcription, coactivator/corepressor O88712 13016 5 B1|5 17.52 cM mouse S158-p 455351 REGTRVQsVEQIREV 2-Hacid_dh; 2-Hacid_dh_C protein degradation; intracellular localization transcription, induced 26416879 7 2 0 Unphosphorylated is stabilized in cytoplasm and nucleus. -NOX4 NOX4 Cell cycle regulation; EC 1.6.3.-; Membrane protein, integral; Membrane protein, multi-pass; Nucleolus; Oxidoreductase Q9NPH5 50507 11q14.3 human Y566-p 57848101 LSNQNNSyGTRFEYN molecular association, regulation; enzymatic activity, inhibited CYBA(DISRUPTS) 27525436 1 1 0 -Dnm2 DYN2 EC 3.6.5.5; Hydrolase; Microtubule-binding; Motility/polarity/chemotaxis; Vesicle P39052 25751 8q13 rat Y597-p 451200 NTEQRNVyKDLRQIE PH molecular association, regulation; intracellular localization carcinogenesis, induced; cell motility, induced; cell growth, induced; exocytosis, induced; cytoskeletal reorganization caveolin-1(INDUCES) 15007081; 20231454; 21841817 5 1 2 DYN2 Y597 is required for endocytosis and albumin transport. ; Golgi integrity and vesiculation during the secretory process; Wild-type showed increased motility and increase of large distal tumors, compared to Y231/597F mutant. -LIME1 LIME1 Adaptor/scaffold; Membrane protein, integral Q9H400 54923 20q13.33 human Y167-p 463652 ASPVVAEyARVQKRK LIME1 molecular association, regulation CSK(INDUCES) 14610046 1 1 11 -VDR VDR DNA-binding; Nuclear receptor; Transcription factor P11473 7421 12q13.11 human S182-p 454433 TPSFSGDsSSSCSDH molecular association, regulation transcription, inhibited RXRA(DISRUPTS) 15474498 1 0 0 -ALOX5 5-LO EC 1.13.11.34; Lipid Metabolism - arachidonic acid; Lipid Metabolism - linoleic acid; Nuclear envelope; Oxidoreductase P09917 240 10q11.21 human S272-p 450169 CSLERQLsLEQEVQQ Lipoxygenase intracellular localization; enzymatic activity, induced 11844797; 12670876; 16165096; 18978352; 26173130; 28257804 9 1 2 -MAPT Tau iso8 ACETYLTRANSFERASE; Acetyltransferase; Cytoskeletal P10636-8 4137 17q21.31 human K369-ac 461556 HVPGGGNkKIETHKL phosphorylation 28855586 4 2 27 inhibts Tau iso8 phosphorylation and microtubule binding, ameliorates amyloid-beta toxicity -Aqp4 AQP4 Channel, misc.; Membrane protein, integral; Membrane protein, multi-pass; Transporter; Transporter, aquaporin family P47863 25293 18p13 rat S180-p 467301 TIFASCDsKRTDVTG MIP molecular association, regulation; protein conformation AQP4(INDUCES) 23651078 4 0 0 phosphosite of monomer D is involved in an ionic interaction with monomer B and C -ATG7 ATG7 Autophagy; Ubiquitin conjugating system O95352 10533 3p25.3 human K413-ub 1881880200 CLGGGKPkALAAADR ubiquitination autophagy, induced 35316220 1 1 0 L. monocytogenes infection induced autophagosome accumulation -DAB2 DAB2 Adaptor/scaffold; Tumor suppressor P98082 1601 5p13.1 human S394-p 483636 NGFSVKSsPNPFVGS molecular association, regulation CLTA(INDUCES) 21097498 2 12 0 -MAPT Tau iso8 ACETYLTRANSFERASE; Acetyltransferase; Cytoskeletal P10636-8 4137 17q21.31 human K254-ub 486344 PVPMPDLkNVKSKIG Tubulin-binding protein stabilization 16443603 2 4 0 -CYP17A1 CYP17A1 EC 1.14.99.9; EC 4.1.2.30; Lipid Metabolism - C21-steroid hormone; Oxidoreductase P05093 1586 10q24.32 human S258-p 464643 KEKFRSDsITNMLDT p450 enzymatic activity, inhibited; enzymatic activity, induced 16616104; 20160131 2 0 0 in vitro; S258 mutants were impaired in both 17alpha-hydroxylase and C(17-20) lyase activities -MECP2 MECP2 Transcription, coactivator/corepressor P51608 4204 Xq28 human Y120-p 37042901 SGRSAGKyDVYLINP MBD molecular association, regulation; intracellular localization; protein conformation cell cycle regulation; cell motility, inhibited DNA(DISRUPTS) 25527496; 29428602 2 0 0 localized to the centrosome, colocalized with gamma-tubuliin and pericentrin -FOXP3 FOXP3 C2H2-type zinc finger protein; Cell cycle regulation; DNA-binding; Transcription factor Q9BZS1 50943 Xp11.23 human K252-ac 31914103 QLVLEKEkLSAMQAH FOXP-CC protein stabilization 23644046 1 0 0 -Celf1 CELF1 Cell development/differentiation; RNA processing; RNA-binding P28659 13046 2 E1|2 50.44 cM mouse S302-p 3347301 TSSGSSPsSSSSNSV protein stabilization translation, inhibited 28559429 6 1 0 -KDR VEGFR2 EC 2.7.10.1; KINASE; Kinase, protein; Membrane protein, integral; Protein kinase, TK; Protein kinase, tyrosine (receptor) P35968 3791 4q12 human Y1054-p 447899 FGLARDIyKDPDYVR PK_Tyr_Ser-Thr molecular association, regulation; receptor internalization, altered; enzymatic activity, induced PLCG1(INDUCES); CBL(INDUCES) 10102632; 17372230 14 3 105 -Fndc5 FNDC5 Membrane protein, integral Q8K4Z2 384061 4|4 D2.2 mouse K187-ac 1881215702 EPNNNKEkTKSASET ubiquitination 33754067 1 0 0 SIRT2-dependent deacetylation and deubiquitination increases stability -YAP1 YAP1 Oncoprotein; Transcription, coactivator/corepressor P46937 10413 11q22.1 human T83-p 27460703 KTANVPQtVPMRLRK molecular association, regulation; intracellular localization carcinogenesis, inhibited; transcription, inhibited KPNA1(DISRUPTS); KPNA7(DISRUPTS) 32271880 1 2 0 -NKX3-1 NKX3-1 DNA-binding; Transcription factor; Tumor suppressor Q99801 4824 8p21.2 human S196-p 4825100 GDLEKHSsLPALKEE protein degradation; ubiquitination 18757402 2 1 0 -NR3C1 GR DNA-binding; Mitochondrial; Nuclear receptor; Transcription factor P04150 2908 5q31.3 human T524-p 1872513504 NKTIVPAtLPQLTPT molecular association, regulation 14-3-3 zeta(INDUCES) 33744286 1 1 0 -Myocd myocardin Cell development/differentiation; Transcription factor Q8VIM5 214384 11|11 B3 mouse S812-p 10791200 EVLLNSHsPIGKVSD molecular association, regulation transcription, inhibited CBP(DISRUPTS) 19776005 1 0 0 -FOXP3 FOXP3 C2H2-type zinc finger protein; Cell cycle regulation; DNA-binding; Transcription factor Q9BZS1 50943 Xp11.23 human S274-p 34370255 TKASSVAsSDKGSCC protein degradation; ubiquitination 27432879 1 1 1 -SLC4A4 SLC4A4 Membrane protein, integral; Membrane protein, multi-pass; Transporter; Transporter, SLC family Q9Y6R1 8671 4q13.3 human S1026-p 469803 KKKKKKGsLDSDNDD activity, induced; molecular association, regulation CA2(INDUCES) 12411514; 12730338 3 10 2 S1026 phosphorylation alters stoichiometry shift, while T49 mediates increase in membrane conductance. -Kcnb1 Kv2.1 Channel, cation; Channel, ligand-gated; Channel, potassium; Membrane protein, integral; Membrane protein, multi-pass P15387 25736 3q42 rat S771-p 473561 QLLYSVDsSPPKSLH activity, inhibited 16917065 1 0 0 -TUBA1A TUBA1A Cytoskeletal; Motility/polarity/chemotaxis P81947 404053 cow K40-ac 460619 DGQMPSDkTIGGGDD Tubulin molecular association, regulation; acetylation; protein conformation cytoskeletal reorganization 19118000; 23110214 71 7 11 -NOTCH1 Notch 1 Membrane protein, integral; Motility/polarity/chemotaxis; Oncoprotein; Receptor, misc.; Transcription factor P46531 4851 9q34.3 human S2524-p 467290 PDQWSSSsPHSNVSD protein degradation; receptor inactivation, altered 16880534 1 0 0 Alanine mutation of 4 serines (S2522/S2523/S2524/S2525) causes increased protein stability. -FGFR3 FGFR3 EC 2.7.10.1; KINASE; Kinase, protein; Membrane protein, integral; Protein kinase, TK; Protein kinase, tyrosine (receptor) P22607 2261 4p16.3 human Y577-p 463335 RRPPGLDySFDTCKP PK_Tyr_Ser-Thr cell growth, altered 11294897 1 1 8 -DYRK2 DYRK2 iso2 EC 2.7.12.1; KINASE; Kinase, protein; Protein kinase, CMGC; Protein kinase, dual-specificity (non-receptor) Q92630-2 8445 12q15 human S498-p 1874397820 SKLPPPSsSASKLRT enzymatic activity, induced cell cycle regulation; apoptosis, induced 34363019 1 1 0 -TNNI3 TNNI3 Actin-binding; Motility/polarity/chemotaxis; Motor P19429 7137 19q13.42 human S44-p 450691 KKSKISAsRKLQLKT molecular association, regulation; activity, inhibited TNNC1(DISRUPTS) 15134451; 24116014 22 3 0 reduced maximal force generation -UVRAG UVRAG Autophagy Q9P2Y5 7405 11q13.5 human K517-ub 1871613604 ENERLQYkTPPPSYN autophagy, induced 30686098 1 0 0 -Skp2 SKP2 Cell cycle regulation; UBIQUITIN LIGASE; Ubiquitin conjugating system; Ubiquitin ligase Q9Z0Z3 27401 15|15 A1 mouse S256-p 1296362400 ATLLSSCsRLDELNL molecular association, regulation; ubiquitination; phosphorylation carcinogenesis, induced; cell motility, induced; transcription, induced; signaling pathway regulation CUL1(INDUCES) 30413706 3 1 0 induces ubiquitination and phosphorylation of AKT, GLUT1 transcription, induces AKT signaling -MDM2 MDM2 EC 6.3.2.-; EC 6.3.2.19; Inhibitor; Ligase; NEDDYLATION LIGASE; Neddylation Ligase; Nucleolus; Oncoprotein; UBIQUITIN LIGASE; Ubiquitin conjugating system; Ubiquitin ligase Q00987 4193 12q15 human S395-p 447898 SQESEDYsQPSTSSS protein degradation; protein stabilization; molecular association, regulation; ubiquitination; intracellular localization; enzymatic activity, inhibited; protein conformation cell cycle regulation; carcinogenesis, inhibited; cell growth, inhibited; signaling pathway regulation; translation, induced Rb(INDUCES); p53(DISRUPTS) RNA(INDUCES) 12383858; 17936559; 21986495; 24813712; 27215386; 31163228; 31652301; 32453417; 33400740; 33683975; 35674210 15 2 0 prevents E2F1 mRNA interaction; induces TP53 stabilization; induces binding to p53 mRNA; induces MDM2 p53 pathway; induce its RNA binding conformation, but also to govern MDM4 binding to p53 mRNA -IQGAP1 IQGAP1 GAP; GAP, Ras; Motility/polarity/chemotaxis P46940 8826 15q26.1 human S1441-p 455635 TPDKMKKsKSVKEDS molecular association, regulation cytoskeletal reorganization; cell adhesion, inhibited RAC1(DISRUPTS) 15695813; 28739799 4 3 2 -TP53 p53 Activator; DNA-binding; Motility/polarity/chemotaxis; Nuclear receptor co-regulator; Transcription factor; Tumor suppressor P04637 7157 17p13.1 human K373-ub 464659 SSHLKSKkGQSTSRH protein degradation; molecular association, regulation; intracellular localization transcription, inhibited ING1(DISRUPTS) 11046142; 17371868; 19927155; 21731648 9 0 0 K370/372/373/381/382/386/R mutant shows 613-fold activation of p53; binds unmodified or six multimonoubiquitinated forms of wild-type p53 -CNN1 calponin 1 Actin-binding; Contractile; Motility/polarity/chemotaxis; Myosin-binding P26932 396522 chicken T184-p 469595 QGMTAYGtRRHLYDP Calponin molecular association, regulation ACTA1(DISRUPTS) 10873572 1 0 1 f-actin (rabbit skeletal muscle) shown by co-sedimentation -Cdkn1a p21Cip1 Cell cycle regulation; Inhibitor Q64315 114851 rat S146-p 447836 GRKRRQTsLTDFYHS cell cycle regulation; carcinogenesis, induced 34569407 10 1 0 -P2rx2 P2X2 Channel, cation; Channel, ligand-gated; Membrane protein, integral; Membrane protein, multi-pass P49653 114115 12q16 rat T18-p 450951 SAFWDYEtPKVIVVR P2X_receptor receptor desensitization, altered 10744703 1 0 0 -H2AZ1 H2AZ DNA-binding P0C0S5 3015 4q23 human K101-m2 62489900 EELDSLIkATIAGGG Histone_H2A_C protein stabilization; molecular association, regulation cell cycle regulation; carcinogenesis, induced; chromatin organization, altered; cell growth, induced; transcription, induced LANP-L(DISRUPTS) 27569210 1 0 0 decreases histone displacement on chromatin -ENPP2 ENPP2 EC 3.1.4.39; Lipid Metabolism - ether lipid; Motility/polarity/chemotaxis; Phosphodiesterase; Secreted; Secreted, signal peptide Q13822 5168 8q24.12 human T210-p 451183 RPVYPTKtFPNLYTL Phosphodiest molecular association, regulation; protein conformation 27268273 2 0 0 ENPP2 follows the associative two-step in-line displacement mechanism -ITGB4 ITGB4 iso2 Cell adhesion; Membrane protein, integral; Motility/polarity/chemotaxis; Receptor, misc. P16144-2 3691 17q25.1 human Y1494-p 456323 LQGYSVEyQLLNGGE fn3 activity, induced; molecular association, regulation; intracellular localization cell motility, altered; autophagy, inhibited ANXA7(INDUCES); SHP-2(INDUCES) 20855525; 24007983; 26918348 6 0 1 -Zfp809 ZFP809 Transcription factor G3X9G7 235047 9|9 A3 mouse K391-ub 63108400 YGIMDFVkAWSRCII protein degradation 28115710 1 0 0 -AP2B1 AP2B1 Vesicle P63010 163 17q12 human Y277-p 462925 LPKDSDYyNMLLKKL Adaptin_N molecular association, regulation; intracellular localization DNA(DISRUPTS) 31492751 1 1 7 -EIF4B EIF4B RNA-binding; Translation; Translation initiation P23588 1975 12q13.13 human S504-p 452271 SSDTEQQsPTSGGGK neural plasticity; translation, induced 21635931 2 55 22 -ADRA1D ADRA1D GPCR, family 1; Membrane protein, integral; Membrane protein, multi-pass; Receptor, GPCR P25100 146 20p13 human T507-p 1346843002 LGPFRRPtTQLRAKV receptor internalization, induced; molecular association, regulation; intracellular localization; receptor internalization, altered signaling pathway regulation ARRB1(INDUCES) 29551601; 30419287 2 1 0 triggers the calcium signaling pathway; regulates ERK signaling pathway, induces calcium signaling de-sensitization -PML PML Nucleolus; Oncoprotein; SUMO LIGASE; SUMO conjugating system; SUMO ligase; Transcription factor; Tumor suppressor; Ubiquitin conjugating system P29590 5371 15q24.1 human K401-ub 2885407 KDAAVSKkASPEAAS DUF3583 protein degradation cell differentiation, induced 18408733 1 4 4 -SMAD2 SMAD2 DNA-binding; Transcription factor Q15796 4087 18q21.1 human S417-p 447569 RMCTIRMsFVKGWGA MH2 molecular association, regulation transcription, inhibited; signaling pathway regulation SMAD4(DISRUPTS); TGFBR1(DISRUPTS) 22393057 1 1 0 TGFB signaling -ABL2 Arg EC 2.7.10.2; KINASE; Kinase, protein; Oncoprotein; Protein kinase, TK; Protein kinase, tyrosine (non-receptor) P42684 27 1q25.2 human Y161-p 449482 QGWVPSNyITPVNSL enzymatic activity, induced 34144039 2 5 215 -SIK2 QIK EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, CAMK; Protein kinase, Ser/Thr (non-receptor) Q9H0K1 23235 11q23.1 human T175-p 456035 KSGELLAtWCGSPPY Pkinase enzymatic activity, induced 24841198; 27478041 6 1 0 -BRCA1 BRCA1 EC 6.3.2.-; Nuclear receptor co-regulator; Transcription, coactivator/corepressor; Tumor suppressor; UBIQUITIN LIGASE; Ubiquitin conjugating system; Ubiquitin ligase P38398 672 17q21.31 human S1423-p 448036 AVLEQHGsQPSNSYP molecular association, regulation; phosphorylation cell cycle regulation; DNA repair, altered ATM(INDUCES) 10550055; 11313470; 12183412; 15159397; 25939603; 26320175; 34301763 14 1 1 -FGFR2 FGFR2 EC 2.7.10.1; KINASE; Kinase, protein; Membrane protein, integral; Oncoprotein; Protein kinase, TK; Protein kinase, tyrosine (receptor) P21802 2263 10q26.13 human Y656-p 472824 RDINNIDyYKKTTNG PK_Tyr_Ser-Thr carcinogenesis, induced; cell growth, induced 35428876 2 8 66 -CHAT CHAT iso3 ACETYLTRANSFERASE; Acetyltransferase; EC 2.3.1.6; Lipid Metabolism - glycerophospholipid P28329-3 1103 10q11.23 human T255-p 454038 TVLVKDStNRDSLDM Carn_acyltransf enzymatic activity, induced 15381704 1 0 0 -Dnm1l DRP1 Apoptosis; EC 3.6.5.5; Endoplasmic reticulum; Hydrolase; Microtubule-binding; Mitochondrial; Motor O35303 114114 11q23 rat S656-p 483971 VPVARKLsAREQRDC molecular association, regulation; intracellular localization autophagy, induced; apoptosis, inhibited; autophagy, inhibited; cytoskeletal reorganization FIS1(INDUCES) 17721437; 18695047; 21637291; 29313986; 33624140; 35562960; 36805606 103 3 0 -Foxo1 FOXO1A DNA-binding; Nuclear receptor co-regulator; Oncoprotein; Transcription factor Q9R1E0 56458 3 C|3 23.19 cM mouse T24-p 448560 LPRQRSCtWPLPRPE intracellular localization transcription, inhibited 10377430; 10698940; 22848439 62 6 39 enhances hypoglycemic effect -PKM PKM Carbohydrate Metabolism - glycolysis and gluconeogenesis; Carbohydrate Metabolism - pyruvate; EC 2.7.1.40; KINASE; Kinase, other; Mitochondrial; Nucleotide Metabolism - purine P14618 5315 15q23 human K206-ub 12412148 NGGSLGSkKGVNLPG PK enzymatic activity, inhibited carcinogenesis, inhibited; cell growth, inhibited 26975375 1 3 10 -Nr5a2 NR5A2 DNA-binding; Nuclear receptor; Transcription factor P45448 26424 1 59.98 cM|1 E4 mouse K173-sm 6124700 KCIDVGMkLEAVRAD zf-C4 intracellular localization transcription, inhibited 19125815 1 0 0 -Bmal1 BMAL1 DNA-binding; Transcription factor Q9WTL8 11865 7 F1|7 59.17 cM mouse S522-p 1878257206 IRGSSPSsCGSSPLN activity, induced transcription, induced 35902736 1 1 0 -Banp BANP Tumor suppressor Q8VBU8 53325 8 E1|8 70.82 cM mouse S347-p 475059 SFSRRTPsSSSYSAS intracellular localization cell cycle regulation; cell growth, inhibited 17229733; 20006573 2 0 0 translocation from nucleus to cytoplasm; anti-tumorigenic activity, P44 peptide could efficiently activate p53 -OCLN occludin Cell adhesion; Membrane protein, integral; Membrane protein, multi-pass; Motility/polarity/chemotaxis Q16625 100506658 5q13.2 human Y398-p 5393504 KRTEQDHyETDYTTG molecular association, regulation; intracellular localization ZO1(INDUCES) 19017651 1 3 1 -KAT2B PCAF ACETYLTRANSFERASE; Acetyltransferase; EC 2.3.1.48; Nuclear receptor co-regulator Q92831 8850 3p24.3 human K89-m1 7482014 LRSAPRAkKLEKLGV PCAF_N intracellular localization 19351588 1 0 0 -Cycs CYCS Apoptosis; Mitochondrial; Oxidoreductase; PHOSPHATASE; Protein phosphatase, Ser/Thr (non-receptor) P62897 13063 6 B2.3|6 24.32 cM mouse T29-p 4710693 EKGGKHKtGPNLHGL Cytochrom_C protein stabilization; enzymatic activity, inhibited 27758862 1 12 0 -STX3 STX3 Cell adhesion; Membrane protein, integral; Vesicle Q13277 6809 11q12.1 human T14-p 31960301 QLKAKQLtQDDDTDA molecular association, regulation; protein conformation VAMP2(INDUCES); STXBP1(DISRUPTS); SNAP-25(INDUCES) 35661757 5 1 0 -FZR1 FZR1 UBIQUITIN LIGASE; Ubiquitin conjugating system Q9UM11 51343 19p13.3 human T121-p 3827860 DRRLQPStPEKKGLF protein stabilization; activity, inhibited apoptosis, induced 18818692; 30498084 3 1 16 inhibits cyclin B1 degradation; AURKA stabilization -PGK1 PGK1 Carbohydrate Metabolism - glycolysis and gluconeogenesis; EC 2.7.2.3; KINASE; Kinase, other P00558 5230 Xq21.1 human Y76-p 463986 GVPMPDKySLEPVAV PGK molecular association, regulation cell growth, altered RNA(DISRUPTS) 19784757 1 4 102 binds to uPAR mRNA and regulates the uPAR expression induced by uPA treatment -Mst1r Ron EC 2.7.10.1; KINASE; Kinase, protein; Membrane protein, integral; Protein kinase, TK; Protein kinase, tyrosine (receptor) Q62190 19882 9 59.07 cM|9 F1 mouse Y1265-p 456483 LTRGAPPyPHIDPFD PK_Tyr_Ser-Thr enzymatic activity, induced Src(NOT_REPORTED) 16103119 1 0 0 this site is responsible for constitutive activation of the MAP kinase pathway -Ccdc88a girdin Actin-binding Q5SNZ0 108686 11|11 A3.3 mouse S233-p 4725929 HASSSAQsPCGSPGM molecular association, regulation SLC3A2(INDUCES) 29538402 1 16 7 negatively regulates amino acid signaling -MLLT1 MLLT1 Oncoprotein; Transcription regulation Q03111 4298 19p13.3 human S398-p 40666502 FEPSQNHsQGPLRSM molecular association, regulation transcription, inhibited BMI1(INDUCES) 25921070 1 0 0 -UBE2I UBC9 EC 6.3.2.-; EC 6.3.2.19; Ligase; Nuclear receptor co-regulator; SUMO LIGASE; SUMO conjugating system; SUMO ligase; UBIQUITIN LIGASE; Ubiquitin conjugating system; Ubiquitin ligase P63279 7329 16p13.3 human T35-p 18914511 PTKNPDGtMNLMNWE UQ_con sumoylation cell growth, induced; transcription, induced 25867063 1 1 0 induces global sumoylation -LSR LISCH Membrane protein, integral; Receptor, misc. Q86X29 51599 19q13.12 human S493-p 468133 ARRPRARsVDALDDL molecular association, regulation 14-3-3 beta(INDUCES) 19648646 1 38 49 yeast 14-3-3 used for binding assay -CAMK4 CAMK4 EC 2.7.11.17; KINASE; Kinase, protein; Protein kinase, CAMK; Protein kinase, Ser/Thr (non-receptor) Q16566 814 5q22.1 human S12-p 2135600 TVPSCSAsSCSSVTA transcription, altered 8702940 1 0 1 -ATR ATR EC 2.7.11.1; KINASE; Kinase, protein; Membrane protein, integral; Protein kinase, Ser/Thr (non-receptor); Protein kinase, atypical Q13535 545 3q23 human T1566-p 22561301 DDQHTINtQDIASDL cell cycle regulation; cell growth, induced 21908846 1 1 0 -Cycs CYCS Apoptosis; Mitochondrial; Oxidoreductase; PHOSPHATASE; Protein phosphatase, Ser/Thr (non-receptor) P62898 25309 4q24 rat Y49-p 473243 GQAAGFSyTDANKNK Cytochrom_C molecular association, regulation; activity, inhibited apoptosis, altered 20586425 4 4 4 Y48E mutation decreases CYCS redox potential; decreases affinity to cardiolipin -STK11 LKB1 Autophagy; EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, CAMK; Protein kinase, Ser/Thr (non-receptor); Tumor suppressor Q15831 6794 19p13.3 human T363-p 448151 IEDDIIYtQDFTVPG enzymatic activity, induced 12805220 6 0 0 STRAD increases LKB1 activation -MPLKIP TTDN1 Cell cycle regulation Q8TAP9 136647 7p14.1 human T120-p 478367 QGSPRTStPFGSGRV MPLKIP molecular association, regulation PLK1(INDUCES) 17310276 1 8 16 -PEAK1 PEAK1 EC 2.7.10.2; KINASE; Kinase, protein; Protein kinase, Other; Protein kinase, Ser/Thr (non-receptor) Q9H792 79834 15q24.3 human Y635-p 449709 IVINPNAyDNLAIYK molecular association, regulation cell motility, induced; cell growth, induced; cytoskeletal reorganization GRB2(INDUCES); SHC1(INDUCES); tensin 3(INDUCES) 23378338; 35687021 2 43 1179 -Kcnb1 Kv2.1 Channel, cation; Channel, ligand-gated; Channel, potassium; Membrane protein, integral; Membrane protein, multi-pass P15387 25736 3q42 rat Y814-p 22874700 FLRPNCVySSEGLTG intracellular localization 22106938 2 1 1 regulates intracellular trafficking of Kv2.1 -ANKRD28 ANKRD28 Protein phosphatase, regulatory subunit O15084 23243 3p25.1 human S1011-p 459225 TNTSKTVsFEALPIM intracellular localization transcription, inhibited PPP1CA(DISRUPTS) 16564677; 17023142 2 25 0 -Ano1 ANO1 Membrane protein, integral; Membrane protein, multi-pass; Transporter; Transporter, ion channel Q8BHY3 101772 7|7 F5 mouse S673-p 288031701 YLKLRRQsPSDREEY Anoctamin activity, induced; protein conformation; activity, inhibited cell cycle regulation; cell growth, induced 29081444; 33199590 2 0 0 regulating ANO1 Cl- currents -KEAP1 KEAP1 Endoplasmic reticulum; Motility/polarity/chemotaxis; Transcription regulation; UBIQUITIN LIGASE; Ubiquitin conjugating system Q14145 9817 19p13.2 human K323-ub 1883516303 VMPCRAPkVGRLIYT protein degradation 36163178 1 0 0 -PLCG1 PLCG1 Carbohydrate Metabolism - inositol phosphate; EC 3.1.4.11; Motility/polarity/chemotaxis; Phospholipase P08487 281987 cow Y783-p 447667 EGRNPGFyVEANPMP enzymatic activity, induced transcription, altered 15879121 92 42 558 Mutation of Y775 or Y783 reduced PLCG1-mediated calcium mobilization and transcriptional activation -E2F4 E2F4 DNA-binding Q16254 1874 16q22.1 human S384-p 4763386 FAPLLRLsPPPGDHD intracellular localization cell cycle regulation; transcription, induced 23919615 2 5 0 -Camk2b CAMK2B EC 2.7.11.17; KINASE; Kinase, protein; Protein kinase, CAMK; Protein kinase, Ser/Thr (non-receptor) P08413 24245 14q21 rat S343-p 7446037 GLVEQAKsLLNKKAD molecular association, regulation 26291163 1 10 1 inhibits interaction with F-actin, regulates synaptic plasticity -DNMT1 DNMT1 Amino Acid Metabolism - cysteine and methionine; Cell development/differentiation; EC 2.1.1.37; METHYLTRANSFERASE; Methyltransferase; Methyltransferase, DNA; Transcription regulation P26358 1786 19p13.2 human S143-p 3189394 RTPRRSKsDGEAKPE molecular association, regulation; protein stabilization; enzymatic activity, inhibited; methylation carcinogenesis, induced 14-3-3 beta(INDUCES); 14-3-3 gamma(INDUCES); 14-3-3 eta(INDUCES) 21151116; 26553800 3 28 6 inhibits K142 methylation; 14-3-3 overexpression results in genome hypomethylation with and cell invasion -FBXW7 FBXW7 Motility/polarity/chemotaxis; Nucleolus; UBIQUITIN LIGASE; Ubiquitin conjugating system; Ubiquitin ligase Q969H0 55294 4q31.3 human K404-ub 1881459300 GSDDNTLkVWSAVTG protein degradation; molecular association, regulation TRIP12(INDUCES) 33824312 1 1 0 -TFEB TFEB DNA-binding; Transcription factor P19484 7942 6p21.1 human S3-p 54467500 _____MAsRIGLRMQ molecular association, regulation; phosphorylation autophagy, induced mTOR(INDUCES) 29507340 1 0 0 -BRAF BRAF EC 2.7.11.1; KINASE; Kinase, protein; Oncoprotein; Protein kinase, Ser/Thr (non-receptor); Protein kinase, TKL P15056 673 7q34 human K601-ac 1876128200 DFGLATVkSRWSGSH PK_Tyr_Ser-Thr molecular association, regulation; enzymatic activity, induced carcinogenesis, induced BRAF(INDUCES); KSR(INDUCES); RAF1(INDUCES); RKIP(DISRUPTS) 35045286 1 1 0 facilitates melanoma tumorigenesis,dimerization -SREBF1 SREBP-1 DNA-binding; Membrane protein, integral; Membrane protein, multi-pass; Transcription factor P36956 6720 17p11.2 human K418-sm 2793924 DVLMEGVkTEVEDTL transcription, inhibited 12615929 1 0 0 -Usp20 USP20 DEUBIQUITINASE; EC 3.4.19.12; Protease; Ubiquitin conjugating system; Ubiquitin-specific protease Q8C6M1 74270 2|2 B mouse S334-p 7323248 RMKDRKFsWGQQRTN molecular association, regulation; ubiquitination; intracellular localization; phosphorylation apoptosis, altered; cell motility, induced; cell growth, induced; signaling pathway regulation TRAF6(DISRUPTS); ADRB1(INDUCES) 30538132; 37311534 3 13 18 regulates NFKB signaling; deubiquitinates ?1AR and inhibits ?1AR trafficking to lysosomes -MAF MAF Cell development/differentiation; DNA-binding; Oncoprotein; Transcription factor; Tumor suppressor O75444 4094 16q23.2 human K85-ub 37043501 PGSGSEQkAHLEDYY protein degradation; protein stabilization cell growth, inhibited; transcription, induced 25448412; 26825710 2 0 0 -FOXO1 FOXO1A DNA-binding; Nuclear receptor co-regulator; Oncoprotein; Transcription factor Q12778 2308 13q14.11 human S322-p 449112 PRTSSNAsTISGRLS intracellular localization 11980723; 14664696 6 1 0 -HCN2 HCN2 Channel, cation; Membrane protein, integral; Membrane protein, multi-pass Q9UL51 610 19p13.3 human T576-p 15785721 DYIIREGtIGKKMYF cNMP_binding activity, inhibited apoptosis, inhibited 21037554 1 0 0 -DAG1 DAG1 Cytoskeletal; Membrane protein, integral; Motility/polarity/chemotaxis Q14118 1605 3p21.31 human Y892-p 449630 PYRSPPPyVPP____ DAG1 molecular association, regulation; intracellular localization utrophin(DISRUPTS) 10769203; 20512930 8 2 19 -PROM1 CD133 Cell surface; Membrane protein, integral; Membrane protein, multi-pass O43490 8842 4p15.32 human Y828-p 462569 RMDSEDVyDDVETIP molecular association, regulation ARL13B(INDUCES) 32201384 4 2 20 regulates ciliary length -MOB1A MOB1A Protein kinase, regulatory subunit Q9H8S9 55233 2p13.1 human T74-p 2506801 QINMLYGtITEFCTE Mob1_phocein molecular association, regulation NDR1(INDUCES); MST2(INDUCES) 18362890 1 0 0 a tripartite complex -Kcnb1 Kv2.1 Channel, cation; Channel, ligand-gated; Channel, potassium; Membrane protein, integral; Membrane protein, multi-pass Q03717 16500 2 H3|2 87.22 cM mouse S607-p 473555 EATRFSHsPLASLSG Kv2channel activity, induced 24962901 7 6 0 -PFKFB2 PFKFB2 Carbohydrate Metabolism - fructose and mannose; EC 2.7.1.105; EC 3.1.3.46; Kinase, other; Motility/polarity/chemotaxis; Phosphatase (non-protein) O60825 5208 1q32.1 human S483-p 452046 IRRPRNYsVGSRPLK molecular association, regulation 14-3-3 beta(INDUCES) 12853467 8 36 101 -PHB2 BAP37 Mitochondrial; Nuclear receptor co-regulator; Transcription, coactivator/corepressor Q99623 11331 12p13.31 human K200-ub 15385266 YTAAVEAkQVAQQEA Band_7 molecular association, regulation; ubiquitination autophagy, induced LC3B(INDUCES) 36379251 1 4 2 BAP37 promotes ef?cient mitophagy -FOXK2 FOXK2 DNA-binding; Transcription factor Q01167 3607 17q25.3 human S428-p 3193961 FAQSAPGsPLSSQPV protein stabilization apoptosis, altered; transcription, altered 20810654 1 43 5 -Kcnd2 Kv4.2 Channel, potassium; Membrane protein, integral; Membrane protein, multi-pass Q9Z0V2 16508 6 A2-A3.1|6 8.49 cM mouse S616-p 457613 EGDDRPEsPEYSGGN activity, induced; activity, inhibited neural plasticity 16600858; 18045912; 29790931; 32209671 8 0 0 -En2 En-2 DNA-binding; Transcription factor P09066 13799 5 B1|5 13.94 cM mouse S267-p 452011 LTEQRRQsLAQELSL Homeodomain transcription, altered 15196920 1 1 0 -NR1I2 PXR DNA-binding; Nuclear receptor O75469 8856 3q13.33 human T422-p 27839402 QDIHPFAtPLMQELF molecular association, regulation transcription, inhibited DNA(DISRUPTS) 22976785 1 0 0 -CDC25C CDC25C EC 3.1.3.48; Motility/polarity/chemotaxis; PHOSPHATASE; Protein phosphatase, dual-specificity P30307 995 5q31.2 human S216-p 448418 SGLYRSPsMPENLNR M-inducer_phosp molecular association, regulation; enzymatic activity, inhibited; intracellular localization cell cycle regulation 14-3-3 beta(INDUCES); 14-3-3 epsilon(INDUCES) 10681541; 11333986; 12766774; 15629715; 15735676; 15975956; 17409144; 20637859; 25809478; 34168048; 7982962; 9278512; 9543386 63 14 49 -Rb1 Rb Nuclear receptor co-regulator; Oncoprotein; Transcription, coactivator/corepressor; Tumor suppressor P13405 19645 14 38.73 cM|14 D3 mouse K713-sm 3817003 KVKNIDLkFKIIVTA RB_B protein stabilization; molecular association, regulation cell growth, induced lamin A/C(INDUCES) 27270425 2 0 0 -Brsk2 BRSK2 EC 2.7.11.1; EC 2.7.11.26; KINASE; Kinase, protein; Protein kinase, CAMK; Protein kinase, Ser/Thr (non-receptor) Q69Z98 75770 7|7 F5 mouse S514-p 3572419 SNLTPESsPELAKKS protein stabilization; enzymatic activity, inhibited; phosphorylation 23790753 1 9 6 inhibits axon branching (activated in BRSK2 18A mutant) -ERBB2 HER2 EC 2.7.10.1; KINASE; Kinase, protein; Membrane protein, integral; Oncoprotein; Protein kinase, TK; Protein kinase, tyrosine (receptor) P04626 2064 17q12 human Y1023-p 448682 DLVDAEEyLVPQQGF molecular association, regulation; activity, inhibited cell adhesion, altered; cell growth, altered SHP-2(INDUCES) 16729043; 18332126 7 4 36 -PITPNM1 PITPNM1 Cell surface O00562 9600 11q13.2 human S382-p 451453 DFIDAFAsPVEAEGT molecular association, regulation PLK1(INDUCES) 15125835 1 1 0 -TPI1 TPI1 iso3 Carbohydrate Metabolism - fructose and mannose; Carbohydrate Metabolism - glycolysis and gluconeogenesis; Carbohydrate Metabolism - inositol phosphate; EC 5.3.1.1; Isomerase P60174-3 7167 12p13.31 human S58-p 465652 KMNGRKQsLGELIGT TIM enzymatic activity, induced carcinogenesis, induced; cell motility, induced; cell growth, induced 34936872 3 67 124 -MTA1 MTA1 Motility/polarity/chemotaxis; Nuclear receptor co-regulator; Transcription, coactivator/corepressor Q13330 9112 14q32.33 human K532-m1 27583500 VLKQAVRkPLEAVLR MTA_R1 molecular association, regulation chromatin organization, altered; transcription, inhibited MBD3(INDUCES); CtIP(INDUCES); H3(INDUCES); FALZ(DISRUPTS); HDAC2(INDUCES); CHD-4(INDUCES) 23352453 1 0 0 induces H3Me2K9 loss from chromatin, induces interaction with H3MeK9, H3MeK4, H3AcK9 -RBBP8 CtIP EC 3.1.-.-; Transcription, coactivator/corepressor Q99708 5932 18q11.2 human T126-p 1275585105 ELMNERNtLQEENKK CtIP_N activity, induced DNA repair, induced 30297868 1 1 0 -SLC6A3 DAT Membrane protein, integral; Membrane protein, multi-pass; Transporter; Transporter, SLC family Q01959 6531 5p15.33 human S4-p 454428 ____MSKsKCSVGLM activity, induced 16908408 3 0 0 stimulates DAT-mediated efflux of dopamine -Neurod1 NEUROD1 DNA-binding; Transcription factor Q60867 18012 2 C3|2 47.58 cM mouse S259-p 465678 ALEPFFEsPLTDCTS Neuro_bHLH transcription, induced 12810726 1 0 0 -BNIP3 BNIP3 Membrane protein, integral; Mitochondrial Q12983 664 10q26.3 human S17-p 27421704 QEESLQGsWVELHFS BNIP3 protein stabilization; molecular association, regulation; intracellular localization autophagy, induced; cell growth, inhibited LC3B(INDUCES); GABARAPL2(INDUCES) 23209295; 34654847 2 0 0 modulates mitophagy; S82 is required for binding and S89 positively regulates the affinity for LC3B and GABARAPL2. Mitochondrial degradation. -Srpk2 SRPK2 EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, CMGC; Protein kinase, Ser/Thr (non-receptor) O54781 20817 5 A3|5 10.36 cM mouse T485-p 483237 PSHDRSRtVSASSTG intracellular localization; phosphorylation; enzymatic activity, induced transcription, altered 30373880 3 6 0 increases its nuclear translocation as well as kinase activity, phosphorylates Tau protein S214, regulates mRNA splicing -Trpc6 TRPC6 iso2 Channel, cation; Membrane protein, integral; Membrane protein, multi-pass Q99N77 89823 8q11 rat S714-p 455910 VPFNLVPsPKSLLYL molecular association, regulation Calmodulin(INDUCES); FKBP12(INDUCES); PPP3CA(INDUCES) 15994335 1 0 0 -Nrip1 RIP140 Nuclear receptor co-regulator; Transcription, coactivator/corepressor Q8CBD1 268903 16|16 C3.1 mouse K311-ac 459037 RLQENGQkDVGSSQL NRIP1_repr_1 intracellular localization transcription, inhibited 15879431 1 2 0 -CTNNB1 CTNNB1 Actin-binding; Cell adhesion; Motility/polarity/chemotaxis; Nuclear receptor co-regulator; Oncoprotein; Transcription factor P35222 1499 3p22.1 human T556-p 486193 RRTSMGGtQQQFVEG intracellular localization transcription, inhibited; signaling pathway regulation 31801859 1 26 1 inhibits cGAS/STING mediated DNA-sensing signaling pathway -SYK Syk EC 2.7.10.2; KINASE; Kinase, protein; Protein kinase, TK; Protein kinase, tyrosine (non-receptor) P43405 6850 9q22.2 human Y526-p 447662 LRADENYyKAQTHGK PK_Tyr_Ser-Thr enzymatic activity, induced carcinogenesis, induced; carcinogenesis, inhibited; cell growth, induced ITGAM(INDUCES) 11380624; 18818202; 30923129; 34132782; 37330581; 8657103 50 9 72 -Ikbkb IKKB EC 2.7.11.10; KINASE; Kinase, protein; Protein kinase, Other; Protein kinase, Ser/Thr (non-receptor) O88351 16150 8|8 A2 mouse S177-p 447492 AKELDQGsLCTSFVG Pkinase activity, induced; intracellular localization; phosphorylation; enzymatic activity, induced cell differentiation, induced; transcription, induced 20534585; 23332762; 36896602; 36914767 43 1 0 induces NFKB phosphorylation; induces IkBa degradation; constituvely active IKKE (EE mutant) phosphorylates S26 BAD; osteoclast differentiation -EGFR EGFR EC 2.7.10.1; KINASE; Kinase, protein; Membrane protein, integral; Oncoprotein; Protein kinase, TK; Protein kinase, tyrosine (receptor) P00533 1956 7p11.2 human K737-ub 1065304 LWIPEGEkVKIPVAI PK_Tyr_Ser-Thr receptor internalization, induced; receptor recycling, inhibited; protein degradation 16543144; 17940017 2 7 0 -PTPN18 BDP1 EC 3.1.3.48; Motility/polarity/chemotaxis; PHOSPHATASE; Protein phosphatase, tyrosine (non-receptor) Q99952 26469 2q21.1 human Y303-p 450260 LQNASPHyQNIKENC molecular association, regulation TEC(INDUCES) 14679216 1 0 0 -Sp4 SP4 C2H2-type zinc finger protein; DNA-binding; Transcription factor Q63158 25162 rat S769-p 17548374 VAAISQDsNPATPNV cell differentiation, inhibited 24475768 3 5 0 impairs CG neuron maturation -ACADVL ACADVL EC 1.3.8.9; Lipid Metabolism - fatty acid; Mitochondrial; Oxidoreductase P49748 37 17p13.1 human K299-ac 3811946 THGPPEKkMGIKASN Acyl-CoA_dh_M molecular association, regulation; enzymatic activity, induced CRLS1(INDUCES) 25811481 1 0 1 both SIRT3 and SIRT5 KO show reduced afinity for CRLS1 -STAP2 STAP2 Adaptor/scaffold Q9UGK3 55620 19p13.3 human Y22-p 11500606 GVLPSHYyESFLEKK PH transcription, altered 12540842 1 0 0 -GMFB GMF-beta Actin-binding; Inhibitor; Motility/polarity/chemotaxis P60983 2764 14q22.2 human S83-p 451485 QHDDGRVsYPLCFIF Cofilin_ADF signaling pathway regulation 32123210 2 0 0 p38MAPK pathway -MYH7 MYH7 Motility/polarity/chemotaxis; Motor P12883 4625 14q11.2 human K951-ac 15292422 EDECSELkRDIDDLE Myosin_tail_1 protein conformation 35502901 0 1 58 -CAV1 caveolin-1 Adaptor/scaffold; Motility/polarity/chemotaxis; Nuclear receptor co-regulator Q03135 857 7q31.2 human K30-ub 486850 NIYKPNNkAMADELS molecular association, regulation; intracellular localization UBXN6(INDUCES); VCP(INDUCES) 23335559 1 6 6 CAV1 ubiquitylation and binding to the VCP-UBXD1 complex and sorting into lysosomes -GAPDH GAPDH Carbohydrate Metabolism - glycolysis and gluconeogenesis; EC 1.2.1.12; Oxidoreductase P04406 2597 12p13.31 human T237-p 4658322 GMAFRVPtANVSVVD Gp_dh_C intracellular localization apoptosis, inhibited 21979951 2 4 32 increases cell survival -CDK16 CDK16 Cell cycle regulation; EC 2.7.11.22; KINASE; Kinase, protein; Motility/polarity/chemotaxis; Protein kinase, CMGC; Protein kinase, Ser/Thr (non-receptor) Q00536 5127 Xp11.3 human S153-p 453451 SRRLRRVsLSEIGFG molecular association, regulation; intracellular localization; enzymatic activity, inhibited cytoskeletal reorganization CBCP1(DISRUPTS) 12154078; 22184064 3 58 166 -Mkln1 MKLN1 Cell adhesion; Motility/polarity/chemotaxis O89050 27418 6|6 A3.3 mouse S324-p 474504 TEKENGPsARSCHKM Kelch_3 molecular association, regulation MKLN1(INDUCES) 17049906 1 0 0 mutation inhibited MKLN1 self-association -AFDN Afadin Cell adhesion; Motility/polarity/chemotaxis; Oncoprotein P55196 4301 6q27 human T909-p 6208300 VVTVAENtADELARS molecular association, regulation HRas(INDUCES) 12808105 1 0 0 phosphorylation by Bcr induces formation of a complex with Ras -Slc12a1 NKCC2 Membrane protein, integral; Membrane protein, multi-pass; Transporter; Transporter, SLC family P55016 25065 3q36 rat T96-p 458227 TNTYYLQtFGHNTMD AA_permease_N activity, induced; molecular association, regulation; intracellular localization ANXA2(DISRUPTS) 16275913; 18550832; 24526686 15 2 0 Low chloride hypotonic stress enhances raft association of NKCC2 and AnxA2; observed in triple mutant T96/111/101A -TRPC1 TRPC1 Channel, calcium; Membrane protein, integral; Membrane protein, multi-pass P48995 7220 3q23 human S206-p 35542201 SAKNKKDsLRHSRFR TRP_2 signaling pathway regulation 25139746 1 0 0 inhibits 11,12-EET-induced smooth muscle hyperpolarization and relaxation -CAMKK2 CAMKK2 Autophagy; EC 2.7.11.17; KINASE; Kinase, protein; Protein kinase, Other; Protein kinase, Ser/Thr (non-receptor) Q96RR4 10645 12q24.31 human S100-p 4755871 HLSGRKLsLQERSQG molecular association, regulation; enzymatic activity, inhibited; phosphorylation 14-3-3 beta(INDUCES) 32913128 1 27 0 inhibits dephosphorylation at S495 -PAX6 PAX6 iso2 DNA-binding; Motility/polarity/chemotaxis; Transcription factor P26367-2 5080 11p13 human K53-sm 1877427001 LQTHADAkVQVLDNQ PAX protein degradation 32826860 1 0 0 SENP1-mediated de-SUMOylation improves the stability of PAX6 and has protective effects of PAX6 on corneal endothelial injuries -KCNB1 Kv2.1 Channel, cation; Channel, ligand-gated; Channel, potassium; Membrane protein, integral; Membrane protein, multi-pass Q14721 3745 20q13.13 human Y128-p 449085 YWGIDEIyLESCCQA BTB_2 activity, induced; phosphorylation apoptosis, altered; apoptosis, induced 19622611; 26115091 7 0 0 induces phosphorylation of Kv2.1 at S800 -Cd79b Ig-beta Membrane protein, integral; Receptor, misc. P15530 15985 11 E1|11 68.89 cM mouse Y206-p 459287 NIDQTATyEDIVTLR ITAM phosphorylation 9531288 1 1 11 -Stub1 CHIP Adaptor/scaffold; EC 6.3.2.-; EC 6.3.2.19; Ligase; UBIQUITIN LIGASE; Ubiquitin conjugating system; Ubiquitin ligase D4A4T0 287155 10q12 rat S20-p 453857 LGTGGGGsPDKSPSA protein stabilization; molecular association, regulation HSC70(INDUCES) 33082318 3 98 9 -CEP83 CCDC41 Cytoskeletal Q9Y592 51134 12q22 human S698-p 14571164 KQLEELGsSGE____ intracellular localization cytoskeletal reorganization 31455668 1 6 0 affects recruitment of TCTN2 and NPHP1, thus regulating ciliogenesis -ATM ATM DNA repair, damage; EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, Ser/Thr (non-receptor); Protein kinase, atypical; Tumor suppressor Q13315 472 11q22.3 human K3016-ac 1968604 VLMRLQEkLKGVEEG enzymatic activity, induced 17923702 1 0 0 -Zbp1 ZBP1 DNA-binding; Motility/polarity/chemotaxis Q9QY24 58203 2|2 H3 mouse K43-ub 1873076608 KKCQVPKkTLNQVLY z-alpha apoptosis, induced 28634194 1 1 0 induces apoptosis due to influenza A virus infection -Phb1 PHB Apoptosis; Cell cycle regulation; Chaperone; Mitochondrial; Motility/polarity/chemotaxis; Nuclear receptor co-regulator; Oncoprotein; Transcription, coactivator/corepressor P67778 18673 11 59.01 cM|11 D mouse Y259-p 6374000 SRSRNITyLPAGQSV molecular association, regulation; intracellular localization signaling pathway regulation FCER1G(INDUCES) 24023254 5 2 0 FCER1G and Syk-mediated signaling, increases antigen-induced mast cell degranulation -Ikzf1 Ikaros C2H2-type zinc finger protein; DNA-binding; Transcription factor Q03267 22778 11 A1|11 7.02 cM mouse S63-p 451348 NVKVETQsDEENGRA activity, inhibited cell cycle regulation DNA(DISRUPTS) 15024069 2 10 4 -Pitpnb PITPNB Lipid-binding P53811 56305 5|5 F mouse S262-p 451299 ETMRKKGsVRGTSAA activity, induced; intracellular localization apoptosis, induced; cell growth, altered 11953429; 15164762; 17683809 5 17 22 -KCNH2 Kv11.1 Channel, potassium; Membrane protein, integral; Membrane protein, multi-pass; Motility/polarity/chemotaxis Q12809 3757 7q36.1 human Y611-p 3496803 GPSIKDKyVTALYFT Ion_trans activity, induced 18617000 1 1 0 -PTTG1 Securin Cell cycle regulation; Oncoprotein O95997 9232 5q33.3 human T66-p 33663901 ATRKALGtVNRATEK Securin protein degradation; ubiquitination; enzymatic activity, induced chromatin organization, altered 24781523 1 1 0 1) Phosphorylation of securing leads to premature activation of separase. 2) Prevention of securin phosphorylation leads to impaired chromosome segregation and thereby leads to DNA damage. -Mpl MPL Membrane protein, integral; Receptor, cytokine Q08351 17480 4 D2.1|4 54.61 cM mouse S543-p 3091407 DTAALSPsKATVTDS activity, induced; phosphorylation cell growth, altered 10918061 1 0 0 tyrosine phosphorylation of JAK2 -Rorc RORC DNA-binding; Nuclear receptor; Transcription factor P51450 19885 3|3 F2.1 mouse S337-p 25308318 VEFAKRLsGFMELCQ Hormone_recep protein degradation; molecular association, regulation; ubiquitination transcription, inhibited ITCH(INDUCES) 36103814 1 0 1 -MVB12A FAM125A Adaptor/scaffold Q96EY5 93343 19p13.11 human S163-p 3950650 VPKPRGLsRDMQGLS DUF2464 protein processing 18005716 1 6 7 inhibition of HIV-1 release and infectivity -Psma3 PSMA3 EC 3.4.25.1; Protease; Proteasome complex P18422 29670 6q24 rat S243-p 451184 AEKYAKEsLKEEDES protein stabilization 14583091 2 19 0 -RORA RORA DNA-binding; Nuclear receptor P35398 6095 15q22.2 human S100-p 1212279800 CKGFFRRsQQSNATY zf-C4 molecular association, regulation; intracellular localization transcription, induced DNA(INDUCES) 30025153; 32686824; 34157297 4 1 0 -Neurod1 NEUROD1 DNA-binding; Transcription factor Q60867 18012 2 C3|2 47.58 cM mouse S266-p 465679 SPLTDCTsPSFDGPL Neuro_bHLH transcription, induced 12810726 1 0 0 -TYMS TYMS Cofactor and Vitamin Metabolism - one carbon pool by folate; DNA repair, damage; EC 2.1.1.45; METHYLTRANSFERASE; Methyltransferase; Mitochondrial; Nucleotide Metabolism - pyrimidine P04818 7298 18p11.32 human T170-p 1875342300 RVIDTIKtNPDDRRI Thymidylat_synt phosphorylation 34845374 1 1 0 reciprocal phosphorylation/O-GlcNAcylation with T306 O-GlcAc site -APP APP iso4 Apoptosis; Cell surface; Membrane protein, integral; Receptor, misc.; Transcription factor P05067-4 351 21q21.3 human S198-p 450331 EESDNVDsADAEEDD intracellular localization 8999878 1 2 0 APP was phosphorylated within the post Golgi as well as on the cell surface. -RCAN1 RCAN1 Inhibitor P53805 1827 21q22.12 human S167-p 456023 FLISPPAsPPVGWKQ Calcipressin activity, induced; protein degradation transcription, altered 12809556; 16126726 7 38 6 increases calcineurin-inhibiting activity of DSCR1; Phosphorylation of MCIP at S108/S112 by MEKK3 is required for activation of calcineurin/NFAT signaling. -Dpysl2 CRMP-2 Microtubule-binding; Motility/polarity/chemotaxis O08553 12934 14 D1|14 34.6 cM mouse S522-p 448082 PASSAKTsPAKQQAP molecular association, regulation transcription, altered DRP1(DISRUPTS); RHOT2(DISRUPTS) 33318403; 34685760 31 49 84 -ADRA2A ADRA2A GPCR, family 1; Membrane protein, integral; Membrane protein, multi-pass; Receptor, GPCR P08913 150 10q25.2 human S375-p 467300 RVGAAKAsRWRGRQN 7tm_1; TM receptor desensitization, altered 11864637 1 0 0 -Rrad RRAD G protein; G protein, monomeric; G protein, monomeric, RGK O88667 56437 8|8 D3 mouse S301-p 4700229 AFRAKSKsCHDLSVL activity, induced; molecular association, regulation CACNA1C(DISRUPTS) 31969708 3 17 0 induces Cav1.2 currents -GRK5 GRK5 EC 2.7.11.16; KINASE; Kinase, protein; Protein kinase, AGC; Protein kinase, Ser/Thr (non-receptor) P34947 2869 10q26.11 human T10-p 50780063 LENIVANtVLLKARE enzymatic activity, inhibited 31786308 1 2 0 -STAT3 STAT3 DNA-binding; Motility/polarity/chemotaxis; Nuclear receptor co-regulator; Transcription factor P40763 6774 17q21.2 human T714-p 3190177 KTKFICVtPTTCSNT transcription, induced 24615012 1 13 11 dual T714/S727 phosphorylation -STAT2 STAT2 DNA-binding; Transcription factor P52630 6773 12q13.3 human T385-p 1869778701 ILTSNQKtLTPEKGQ STAT_bind protein degradation; molecular association, regulation; ubiquitination carcinogenesis, inhibited; cell growth, inhibited; signaling pathway regulation FBXW7(INDUCES) 31843895 1 0 0 by FBXW7 interaction; FBXW7-STAT2 interaction regulate melanoma cell and colony growth -ALDH1A1 ALDH1A1 Apoptosis; Cofactor and Vitamin Metabolism - retinol; EC 1.2.1.36; GAP; GAP, Ras; Oxidoreductase P00352 216 9q21.13 human T267-p 14567868 KSNLKRVtLELGGKS Aldedh protein stabilization; ubiquitination; intracellular localization; protein conformation; enzymatic activity, induced carcinogenesis, induced; cell motility, induced; cell growth, induced; transcription, induced ALDH1A1(DISRUPTS) 28193222 1 10 1 inhibits ubiquitination, induces drug resistance, T267 site ALDHA1A1 increases enzymatic activity, oligomers dissociate to the monomeric form -Pik3ap1 BCAP Adaptor/scaffold Q9EQ32 83490 19|19 C3 mouse Y460-p 449909 PAATEDLyVEMLQAS molecular association, regulation cell differentiation, altered PIK3R1(INDUCES) 18025150 2 0 0 regulate Akt activation and B-cell differentiation through binding to PI3KR1 -CDC25B CDC25B EC 3.1.3.48; Motility/polarity/chemotaxis; Nuclear receptor co-regulator; PHOSPHATASE; Protein phosphatase, dual-specificity P30305 994 20p13 human S230-p 470115 AFAQRPSsAPDLMCL M-inducer_phosp protein degradation; molecular association, regulation; enzymatic activity, inhibited 14-3-3 sigma(INDUCES) 17003105; 21558810; 23840880 5 4 0 protects against proteosome degradation of centrosomal centrin -Arrb2 ARRB2 Adaptor/scaffold Q91YI4 216869 11 B3|11 42.99 cM mouse T383-p 455373 EFDTNYAtDDDIVFE molecular association, regulation; receptor internalization, altered CLTC(DISRUPTS) 12186555 5 3 2 decreases beta2-adrenergic receptor internalization -Hsf2 HSF2 DNA-binding P38533 15500 10|10 B4 mouse K82-sm 2535908 HIESGIIkQERDGPV HSF_DNA-bind molecular association, regulation DNA(INDUCES) 11278381 3 2 0 -SPAG5 SPAG5 Cell cycle regulation Q96R06 10615 17q11.2 human T111-p 460413 PIPQISStPKTSEEA intracellular localization 18055457 1 4 4 required for SPAG5 localization to the spindle apparatus during mitosis -TEX14 TEX14 Cancer Testis Antigen (CTA); KINASE; Kinase, protein; Protein kinase, Other; Protein kinase, Ser/Thr (non-receptor) Q8IWB6 56155 17q22 human S437-p 25158900 QKAATVKsDIYSFSM PK_Tyr_Ser-Thr protein degradation; intracellular localization cell cycle regulation 22405274 1 0 0 -PXN PXN Adaptor/scaffold; Cell adhesion; Cytoskeletal; Motility/polarity/chemotaxis P49023 5829 12q24.23 human S126-p 450227 SFPNKQKsAEPSPTV Paxillin receptor internalization, induced; intracellular localization cell motility, induced; transcription, induced; cytoskeletal reorganization 23549785; 27941878; 35293964 8 28 4 -Wasf1 WAVE1 Cytoskeletal; Motility/polarity/chemotaxis Q8R5H6 83767 10 B1|10 22.07 cM mouse S441-p 7979602 PPGIRPSsPVAVAAL activity, inhibited 20403076 4 0 0 -TNK1 TNK1 EC 2.7.10.2; KINASE; Kinase, protein; Protein kinase, TK; Protein kinase, tyrosine (non-receptor) Q13470 8711 17p13.1 human S502-p 483166 RMKGISRsLESVLSL molecular association, regulation; intracellular localization; enzymatic activity, inhibited; phosphorylation cell growth, inhibited 14-3-3 sigma(INDUCES); 14-3-3 beta(INDUCES); 14-3-3 theta(INDUCES); 14-3-3 zeta(INDUCES); 14-3-3 epsilon(INDUCES); 14-3-3 gamma(INDUCES) 34504101; 36402225 3 27 1 inhibits substrate phosphorylation -SRC Src EC 2.7.10.2; KINASE; Kinase, protein; Oncoprotein; Protein kinase, TK; Protein kinase, tyrosine (non-receptor) P12931 6714 20q11.23 human Y93-p 4251105 VTTFVALyDYESRTE SH3_1 molecular association, regulation; intracellular localization; protein conformation; phosphorylation; enzymatic activity, induced carcinogenesis, induced; cell growth, induced; signaling pathway regulation PXN(DISRUPTS); FAK(DISRUPTS); P130Cas(DISRUPTS); STAT3(DISRUPTS) 37428018 2 3 0 induces phosphorylation at Y419, induces Ras/MAPK, PI3K/Akt, and Stat3 signaling -ATM ATM DNA repair, damage; EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, Ser/Thr (non-receptor); Protein kinase, atypical; Tumor suppressor Q13315 472 11q22.3 human S1891-p 14735942 TTPANLDsESEHFFR carcinogenesis, inhibited 21765463 4 6 0 -TCF21 TCF21 DEACETYLASE; DNA-binding; Deacetylase; Motility/polarity/chemotaxis; Nuclear receptor co-regulator O43680 6943 6q23.2 human K24-sm 56394107 MLECDGLkMDSNKEF protein stabilization; molecular association, regulation; ubiquitination cell cycle regulation; carcinogenesis, inhibited; cell growth, inhibited; transcription, inhibited HDAC1(INDUCES); HDAC2(INDUCES) 27028856 1 0 0 inhibits ubiquitination, induces HDAC1/2 recruitment to promoter through binding to HDAC1/2 -MAPT Tau iso8 ACETYLTRANSFERASE; Acetyltransferase; Cytoskeletal P10636-8 4137 17q21.31 human Y18-p 454024 MEDHAGTyGLGDRKD protein stabilization; molecular association, regulation 28251926 9 1 0 continued kinesin-1 mediated cargo transport, reduces 3RS-Tau?s inhibition of kinesin-1 motility -Smc3 SMC3 Cell cycle regulation; DNA repair, damage Q9CW03 13006 19|19 D2 mouse K113-ac 41420258 KDQYFLDkKMVTKND SMC_N cell cycle regulation 21139566 1 0 1 -Fosl1 FRA1 DNA-binding; Transcription factor P10158 25445 1q43 rat T231-p 50205700 LMTTPSLtPFTPSLV activity, induced transcription, induced 11756554 2 0 0 -Hnrnpk hnRNP K iso2 RNA splicing; RNA-binding; Spliceosome P61979-2 15387 13|13 B1 mouse S116-p 452369 EEGLQLPsPTATSQL intracellular localization 20960454 4 38 22 -CD300LB CD300LB Membrane protein, integral; Receptor, misc. A8K4G0 124599 17q25.1 human Y188-p 975498 EPGEQPIyMNFSEPL activity, induced transcription, altered GRB2(INDUCES) 16920917; 17928527 2 1 0 cytokine production; Interaction with Grb2 required Fyn. -PIK3AP1 BCAP Adaptor/scaffold Q9DDT2 374268 chicken Y423-p 450044 GEEDESVyESMAHLS molecular association, regulation PIK3R1(INDUCES) 11163197 2 0 9 -ARID4A RbBP1 Adaptor/scaffold P29374 5926 14q23.1 human K444-sm 12004424 EMPLTEVkSEPEENI cell cycle regulation; cell growth, inhibited; transcription, inhibited 16479010 1 0 0 -Flna FLNA Actin-binding; Motility/polarity/chemotaxis; Nuclear receptor co-regulator Q8BTM8 192176 X A7.3|X 37.89 cM mouse S2152-p 451357 TRRRRAPsVANIGSH Filamin activity, induced cell motility, induced; cell differentiation, induced; cytoskeletal reorganization 22698694; 34150753 19 80 999 -Lcp1 L-plastin Actin-binding; Motility/polarity/chemotaxis Q61233 18826 14 D3|14 39.63 cM mouse S7-p 455966 _MARGSVsDEEMMEL cytoskeletal reorganization 30248139 1 19 6 sealing ring formation (nascent sealing zone) in osteoclasts, bone resorption -ABI3 ABI3 Adaptor/scaffold Q9P2A4 51225 17q21.32 human S342-p 4755297 ICVTRRYsDGWCEGV SH3_9 molecular association, regulation WAVE2(DISRUPTS); CYFIP1(DISRUPTS) 28978070 1 7 1 -PRMT6 PRMT6 EC 2.1.1.125; METHYLTRANSFERASE; Methyltransferase; Methyltransferase, protein arginine Q96LA8 55170 1p13.3 human R35-m1 41554252 EREAALErPRRTKRE protein stabilization 23866860 1 2 1 automethylated PRTM6 inhibits HIV1 replication -LRRK2 LRRK2 EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, Ser/Thr (non-receptor); Protein kinase, TKL Q5S007 120892 12q12 human T1410-p 10426324 STHPHFMtQRALYLA Roc molecular association, regulation; enzymatic activity, induced LRRK2(INDUCES) 21060682 6 4 0 T1410A mutation has a small effect on protein's dimerization, it reduces GTPase activity of LRRK2 -ARHGAP35 GRF-1 GAP; GAP, Rac/Rho; Motility/polarity/chemotaxis; Transcription factor; Tumor suppressor Q9NRY4 2909 19q13.32 human S1221-p 10406116 RRRNILRsLRRNTKK RhoGAP_pG1_pG2 molecular association, regulation cytoskeletal reorganization 19673492 1 1 1 prevents the association of the protein with acidic phospholipids and modulate the GTPase substrate preference -Gli2 GLI2 C2H2-type zinc finger protein; Oncoprotein; Transcription factor Q0VGT2 14633 1 E2.3|1 52.17 cM mouse S230-p 2677401 LSRKRALsISPLSDA protein stabilization 25825734 3 7 0 -Ddr2 DDR2 EC 2.7.10.1; KINASE; Kinase, protein; Membrane protein, integral; Protein kinase, TK; Protein kinase, tyrosine (receptor) Q62371 18214 1 H3|1 76.84 cM mouse Y739-p 456862 RNLYSGDyYRIQGRA PK_Tyr_Ser-Thr cell differentiation, induced 37245640 2 9 366 -BECN1 beclin 1 Adaptor/scaffold; Autophagy; Membrane protein, peripheral Q14457 8678 17q21.31 human K430-ac 63237402 EQWTKALkFMLTNLK APG6 protein stabilization; molecular association, regulation; acetylation carcinogenesis, inhibited; autophagy, induced; cell growth, induced; apoptosis, inhibited; autophagy, inhibited rubicon(INDUCES) 26008601; 29088823 2 2 0 CK1 phosphorylation primes for Beclin 1 acetylation; aspirin treatment -BAIAP2L1 IRTKS Adaptor/scaffold; Cytoskeletal Q9UHR4 55971 7q21.3-q22.1 human Y274-p 456190 SNVVRKDyDTLSKCS cell motility, induced 21840312 1 9 231 -Prm1 PRM1 Cancer Testis Antigen (CTA); DNA-binding P02319 19118 16 A1|16 5.87 cM mouse S9-p 451410 ARYRCCRsKSRSRCR Protamine_P1 molecular association, regulation; intracellular localization chromatin organization, altered NPM2(INDUCES); HIRA(INDUCES) DNA(DISRUPTS) 32169215 2 1 0 induces protamine-to-histone exchange on DNA -L1CAM NCAM-L1 Cell adhesion; Membrane protein, integral P32004 3897 Xq28 human Y1151-p 466002 KRSKGGKySVKDKED Bravo_FIGEY protein conformation; phosphorylation 19720049 2 0 0 mutation of this site promotes phosphorylation of N-CAML1 Y1176, Y1211, Y1229 and T1172 -Nfatc2 NFAT1 DNA-binding; Transcription factor Q60591 18019 2 H3|2 88.91 cM mouse S215-p 447845 QNIPAHYsPRTSPIM protein stabilization; ubiquitination carcinogenesis, induced; cell growth, induced; transcription, induced; transcription, inhibited 11030334; 21628454 1 1 4 inhibits ubiquitination of NFAT1 residues K684 and K897 -CREB1 CREB DNA-binding; Transcription factor P16220 1385 2q33.3 human S103-p 451810 DSQESVDsVTDSQKR pKID phosphorylation 17209043 5 0 0 mutation to alanine decreases S121 phosphorylation in cells treated with ionizing radiation -PELP1 PELP1 Nuclear receptor co-regulator; Transcription, coactivator/corepressor Q8IZL8 27043 17p13.2 human S477-p 470174 ADALKLRsPRGSPDG NUC202 cell cycle regulation; carcinogenesis, altered; transcription, altered 20807815 1 25 18 -PXN PXN Adaptor/scaffold; Cell adhesion; Cytoskeletal; Motility/polarity/chemotaxis P49023 5829 12q24.23 human S85-p 451054 HQQPQSSsPVYGSSA Paxillin molecular association, regulation; intracellular localization cell motility, induced; cytoskeletal reorganization; cell adhesion, altered talin 1(INDUCES) 14970194; 22761432 2 50 613 haptotactic cell migration induced, induced focal adhesion formation and formation of invasive protrusions -YAP1 YAP1 iso2 Oncoprotein; Transcription, coactivator/corepressor P46937-2 10413 11q22.1 human S128-p 485035 QHVRAHSsPASLQLG molecular association, regulation apoptosis, inhibited; transcription, induced TEAD1(INDUCES) 22308035 8 12 77 YAP phosphorylation is required for anti-apoptotic activity of YAP in cells which are deficient in p73 alpha/beta expression. -TP53 p53 Activator; DNA-binding; Motility/polarity/chemotaxis; Nuclear receptor co-regulator; Transcription factor; Tumor suppressor P04637 7157 17p13.1 human S366-p 455223 PGGSRAHsSHLKSKK activity, induced; protein stabilization; molecular association, regulation carcinogenesis, inhibited; cell growth, inhibited; transcription, inhibited; transcription, altered S100B(DISRUPTS); p53(INDUCES); 14-3-3 epsilon(INDUCES); 14-3-3 gamma(INDUCES); S100A2(DISRUPTS) DNA(INDUCES) 15659650; 18812399; 19819244; 19933256; 21317290; 35902728 5 1 0 -PPARD PPAR-delta DNA-binding; Nuclear receptor A9XAM2 pig K18-ub 62484402 VREEEKKkEVAEAEG transcription, induced 24058710 1 0 0 -Set SET iso2 Apoptosis; DNA replication; DNA-binding; Inhibitor; Nuclear receptor co-regulator; Oncoprotein; Protein phosphatase, regulatory subunit Q9EQU5-2 56086 2|2 B mouse S9-p 6308300 SAPTAKAsKKELNSN intracellular localization 29760653 6 3 0 Tau pathology; translocation from the nucleus to the cytoplasm, cognitive deficits -Gja1 GJA1 Channel, misc.; Membrane protein, integral; Membrane protein, multi-pass; Motility/polarity/chemotaxis P23242 14609 10 B4|10 28.64 cM mouse S328-p 449993 GQAGSTIsNSHAQPF Connexin43 molecular association, regulation; intracellular localization cytoskeletal reorganization; signaling pathway regulation; endocytosis, inhibited TUBB(INDUCES) 16882687; 21527737; 31189653; 36206047 10 13 0 -HK2 HK2 Carbohydrate Metabolism - amino sugar and nucleotide sugar; Carbohydrate Metabolism - fructose and mannose; Carbohydrate Metabolism - galactose; Carbohydrate Metabolism - glycolysis and gluconeogenesis; Carbohydrate Metabolism - starch and sucrose; EC 2.7.1.1; Kinase, other; Mitochondrial P52789 3099 2p12 human T473-p 28704601 QHRARQKtLEHLQLS Hexokinase_1 protein stabilization; intracellular localization; enzymatic activity, induced carcinogenesis, induced; autophagy, induced; cell motility, induced; cell growth, induced; apoptosis, inhibited 29985480; 31435020 6 0 0 -FLT3 FLT3 EC 2.7.10.1; KINASE; Kinase, protein; Membrane protein, integral; Oncoprotein; Protein kinase, TK; Protein kinase, tyrosine (receptor) P36888 2322 13q12.2 human R972-m2 1879733100 CPHTYQNrRPFSREM molecular association, regulation carcinogenesis, induced; cell growth, induced; apoptosis, inhibited GRB2(INDUCES); Btk(NOT_REPORTED); SHP-2(INDUCES) 31217189; 31395602 2 2 0 -HSPA1A HSP70 Chaperone; Heat shock protein; Motility/polarity/chemotaxis P0DMV8 3303 6p21.33 human S418-p 15403914 TALIKRNsTIPTKQT HSP70 apoptosis, inhibited 25900241 1 2 1 -RAF1 RAF1 EC 2.7.11.1; KINASE; Kinase, protein; Oncoprotein; Protein kinase, Ser/Thr (non-receptor); Protein kinase, TKL P04049 5894 3p25.2 human T491-p 447748 IGDFGLAtVKSRWSG PK_Tyr_Ser-Thr enzymatic activity, induced 11447113; 12551923; 12865432 5 0 0 -RIGI RIGI EC 3.6.4.13; Hydrolase O95786 23586 9p21.1 human K164-ub 7761220 ECLLRSDkENWPKTL CARD_2 activity, induced transcription, induced; signaling pathway regulation 19484123; 28948228 2 1 0 regulates RIG-I activation and RIG-I-mediated IFN-B induction and antiviral capacity; induces DDX58-mediated innate antiviral activity -MDH1 MDH1 Carbohydrate Metabolism - citrate (TCA) cycle; Carbohydrate Metabolism - glyoxylate and dicarboxylate; Carbohydrate Metabolism - pyruvate; EC 1.1.1.37; EC 1.1.1.96; Oxidoreductase P11708 396894 pig R230-m1 29429248 FITTVQQrGAAVIKA Ldh_1_C molecular association, regulation; enzymatic activity, inhibited carcinogenesis, inhibited; cell growth, inhibited MDH1(DISRUPTS) 27840030 1 2 2 disrupts dimerization -Lpp LPP Adaptor/scaffold; Cytoskeletal; Motility/polarity/chemotaxis Q8BFW7 210126 16|16 B1 mouse Y245-p 449712 GPSSGQIyGPGPRGY cell cycle regulation; cell motility, altered 18515860 2 13 114 -KCNK3 KCNK3 Channel, potassium; Membrane protein, integral; Membrane protein, multi-pass O14649 3777 2p23.3 human T383-p 2840502 TGLHSLStFRGLMKR activity, inhibited 23229553 3 1 0 peri-operative atrial fibrillation; TASK1 current inhibition -SH3KBP1 SH3KBP1 Adaptor/scaffold; Apoptosis; Motility/polarity/chemotaxis Q96B97 30011 Xp22.12 human S587-p 457025 TAGHRANsPSLFGTE molecular association, regulation DAB1(DISRUPTS) 23178720 1 54 9 -Pin1 PIN1 EC 5.2.1.8; Isomerase; Nuclear receptor co-regulator Q9QUR7 23988 9 A3|9 7.6 cM mouse S113-p 911089201 ESLASQFsDCSSAKA Rotamase enzymatic activity, induced cytoskeletal reorganization 29559586 1 0 0 supports spine numbers and complexity -RBBP8 CtIP EC 3.1.-.-; Transcription, coactivator/corepressor Q99708 5932 18q11.2 human K513-ac 33625702 SQGSETSkNKFRQVT enzymatic activity, induced 24837676 1 1 0 -TRPV1 TRPV1 Channel, cation; Membrane protein, integral; Membrane protein, multi-pass; Receptor, misc. Q8NER1 7442 17p13.2 human S801-p 450017 VPLLREAsARDRQSA receptor desensitization, altered 18701070 21 0 0 -SECISBP2L SECISBP2L Unknown function Q93073 9728 15q21.1 human T573-p 1868832803 IAKLKRPtALKKVIL molecular association, regulation; intracellular localization cell cycle regulation RHOA(DISRUPTS); KIF23(INDUCES) 31314582 1 0 0 -USP28 USP28 DEUBIQUITINASE; EC 3.4.19.12; Protease; Ubiquitin-specific protease Q96RU2 57646 11q23.2 human S495-p 11952927 STSTESSsQDVESTF UCH molecular association, regulation KLHL2(DISRUPTS) 31938050 2 2 1 ATM mediated phosphorylation disrupts inteaction, destabilizing UCK1 -CACNB2 CACNB2 iso2 Channel, calcium Q08289-2 783 10p12.33-p12.31 human T499-p 470081 RGLSRQEtFDSETQE activity, induced apoptosis, induced 20194790 5 8 30 -DVL3 DVL3 Motility/polarity/chemotaxis Q92997 1857 3q27.1 human S311-p 25736748 EINFENMsNDDAVRV PDZ intracellular localization; activity, inhibited transcription, induced 24993822 1 1 1 -Bub1 BUB1 Cell cycle regulation; EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, Other; Protein kinase, Ser/Thr (non-receptor) O08901 12235 2 F1|2 62.1 cM mouse S447-p 20727507 TPCKVQPsPTVHTKE phosphorylation 34013668 2 9 0 CDK1 phosphorylation at S447 primes TTK phosphorylation at T449 -TTN Titin EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, CAMK; Protein kinase, Ser/Thr (non-receptor) Q8WZ42 7273 2q31.2 human K9564-ub 52490400 ERSERDEkEFEELVS protein degradation 26676607 0 1 0 -RAF1 RAF1 EC 2.7.11.1; KINASE; Kinase, protein; Oncoprotein; Protein kinase, Ser/Thr (non-receptor); Protein kinase, TKL P04049 5894 3p25.2 human S289-p 455311 RSHSESAsPSALSSS activity, induced; molecular association, regulation; intracellular localization; enzymatic activity, inhibited; enzymatic activity, induced cell cycle regulation HRas(DISRUPTS) 15664191; 16407412; 9933647 5 10 55 -PTPN11 SHP-2 iso1 EC 3.1.3.48; Motility/polarity/chemotaxis; PHOSPHATASE; Protein phosphatase, tyrosine (non-receptor) Q06124-1 5781 12q24.13 human S189-p 27458516 GGGERFDsLTDLVEH SH2 molecular association, regulation; enzymatic activity, inhibited; phosphorylation GAB1(DISRUPTS); GAB2(DISRUPTS); PRKD1(DISRUPTS) 25802336 1 1 0 enhances phosphorylation of PKD1 -Cited1 CITED1 Nuclear receptor co-regulator P97769 12705 X D|X 45.25 cM mouse S67-p 27937110 VPTSSSGsTSPIGSP CITED intracellular localization cell differentiation, induced 23529225 1 0 0 S63/64/65/67/69/73/79/80/84A mutation in CITED1 inhibits its translocation into the nucleus and osteoblasts differentiation -MYOD1 MyoD DNA-binding; RNA splicing; Transcription factor P15172 4654 11p15.1 human T115-p 452044 ADRRKAAtMRERRRL HLH activity, inhibited 9751114 2 0 0 -MYL9 MRLC1 Contractile; Motility/polarity/chemotaxis P24844 10398 20q11.23 human T10-p 4964102 SKRAKAKtTKKRPQR intracellular localization cytoskeletal reorganization 22136066 5 0 4 -NFIL3 E4BP4 DNA-binding; Transcription factor Q90Z72 395326 chicken S182-p 452016 CISVIKHsPQSSMSD Vert_IL3-reg_TF protein degradation 15182670 1 0 0 -SLC6A4 SERT Membrane protein, integral; Membrane protein, multi-pass; Transporter P31645 6532 17q11.2 human Y142-p 21697922 MELALGQyHRNGCIS SNF activity, induced; protein stabilization 21992875 1 0 0 increases 5-HT uptake -Def6 DEF6 GEF; GEF, Rac/Rho Q8C2K1 23853 17|17 A3.3 mouse Y144-p 479006 MVPDEVEyLLKKLLG activity, induced; intracellular localization cell differentiation, altered; transcription, altered 18976935 1 0 1 -Cttn Cortactin Actin-binding; Cytoskeletal; Motility/polarity/chemotaxis Q60598 13043 7|7 F5 mouse K314-ac 1880005102 GGKYGVQkDRMDKNA HS1_rep molecular association, regulation; acetylation; intracellular localization DIP2A(INDUCES) 31600191 1 0 0 DIP2A regulates spine morphology and synaptic transmission through acetylation of cortactin; Interaction of DIP2A-cortactin is required for acetylated cortactin; acetylation mimetic cortactin rescues the repetitive behaviors in Dip2a KO mice; acetylation alleviated abnormal PSD95 clustering at the spine head in DIP2A KO neurons -ELK1 ELK1 DNA-binding; Transcription factor P19419 2002 Xp11.23 human K35-ub 1878066501 SRDGGEFkLVDAEEV molecular association, regulation transcription, inhibited DNA(DISRUPTS) 30854565 1 1 0 -KDM5A JARID1A DEMETHYLASE; Demethylase; EC 1.14.11.-; Nuclear receptor co-regulator; Nucleolus; Oxidoreductase; Transcription factor P29375 5927 12p13.33 human S287-p 56630503 RQRKGTLsVNFVDLY intracellular localization 27292631 1 0 0 JARID1A recruitment to the promoters of AKT-regulated genes -Gpr35 GPR35 GPCR, family 1; Membrane protein, integral; Membrane protein, multi-pass; Receptor, GPCR Q9ES90 64095 1|1 D mouse S301-p 1876282806 TPHKSQDsQILSLT_ molecular association, regulation; intracellular localization ARR3(INDUCES) 35101446 1 1 0 -Trpc5 TRPC5 Channel, cation; Membrane protein, integral; Membrane protein, multi-pass Q9QX29 22067 X F2|X 65.49 cM mouse T972-p 455597 DGQEEQVtTRL____ receptor desensitization, induced; molecular association, regulation; receptor desensitization, altered Other(DISRUPTS) 15843439; 33933453 2 0 0 required for desensitization after stimulation by carbachol; disrupts interaction with Phosphatidylinositol 4,5-bisphosphate -HSD17B10 HADH2 Amino Acid Metabolism - valine, leucine and isoleucine degradation; EC 1.1.1.178; EC 1.1.1.35; EC 1.1.1.51; Mitochondrial; Oxidoreductase Q99714 3028 Xp11.22 human K105-ac 1877232022 SKTYNLKkGQTHTLE adh_short enzymatic activity, inhibited cell growth, inhibited RG9MTD1(DISRUPTS) 32703935; 32956445 2 0 0 formation of mt-tRNA splicing complex, regulated mitochondrial function, les cell resistance to stress and cell growth ; mt-tRNA splicing complex -EZH2 EZH2 EC 2.1.1.43; METHYLTRANSFERASE; Methyltransferase; Methyltransferase, protein lysine Q15910 2146 7q36.1 human K307-m2 1878271704 HATPNTYkRKNTETA protein stabilization transcription, inhibited 31693890 1 0 0 EZH2 and SMYD2 collectively modulate the invasion of breast cancer cells -HDAC7 HDAC7 DEACETYLASE; Deacetylase; EC 3.5.1.98; Hydrolase Q8WUI4 51564 12q13.11 human S155-p 455620 FPLRKTVsEPNLKLR intracellular localization; phosphorylation cell motility, altered; cytoskeletal reorganization; transcription, altered; cell growth, altered 15623513; 16980613; 18509061; 18617643 9 34 53 important for VEGF-induced aorta ring angiogenesis; nucleo-cytoplasmic shuttling -RIOK2 RIOK2 EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, Ser/Thr (non-receptor); Protein kinase, atypical Q9BVS4 55781 5q15 human S335-p 471042 TKEGSEFsFSDGEVA cell cycle regulation 21880710 1 28 12 -Prkn PARK2 EC 6.3.2.-; EC 6.3.2.19; Ligase; Translation; Translation regulation; UBIQUITIN LIGASE; Ubiquitin conjugating system; Ubiquitin ligase Q9WVS6 50873 17 A1|17 7.8 cM mouse S65-p 25538008 NCDLEQQsIVHIVQR ubiquitin activity, induced autophagy, induced; cell growth, induced 35145192; 35265609; 36217155 34 10 0 induces mitophagy -Dnm1 DYN1 EC 3.6.5.5; Hydrolase; Microtubule-binding; Motility/polarity/chemotaxis; Motor; Vesicle P21575 140694 3p12 rat Y354-p 450400 SGDQIDTyELSGGAR Dynamin_M molecular association, regulation; protein conformation 12011079 1 1 23 Tyrosine phosphorylation promotes DYN1 self assembly. -MAPT Tau iso8 ACETYLTRANSFERASE; Acetyltransferase; Cytoskeletal P10636-8 4137 17q21.31 human K317-me 1883526400 YKPVDLSkVTSKCGS molecular association, regulation cell growth, inhibited; cell differentiation, induced; cytoskeletal reorganization Tau iso8(INDUCES) 35231567 1 0 0 K317 methylation increases tau self-interactions and promotes tau dimerization, favors the maturation of neuronal cells possibly by facilitating the elongation of processes, facilitates axonal elongation, small yet significant decrease in proliferation of HeLa cells but not Neuro-2a cells -DVL3 DVL3 Motility/polarity/chemotaxis Q92997 1857 3q27.1 human T15-p 34668103 YHLDGQEtPYLVKLP DIX intracellular localization 27486244 2 3 0 centrosomal signal for pS697 accumulated throughout the cell cycle, pS280 only in mitotic spindle and not in the interphase centrosome -MRE11 MRE11A Cell cycle regulation; DNA repair, damage; DNA-binding; Deoxyribonuclease P49959 4361 11q21 human S688-p 449207 SKGVDFEsSEDDDDD protein stabilization; molecular association, regulation cell cycle regulation; DNA repair, inhibited PIH1D1(INDUCES) 28436950; 28512243 2 57 7 -Prkaa1 AMPKA1 Autophagy; EC 2.7.11.1; EC 2.7.11.26; EC 2.7.11.27; EC 2.7.11.31; KINASE; Kinase, protein; Protein kinase, CAMK; Protein kinase, Ser/Thr (non-receptor) Q5EG47 105787 15|15 A1 mouse S494-p 4717473 GTATPQRsGSISNYR AdenylateSensor enzymatic activity, inhibited 26797128 3 2 15 -MDC1 MDC1 Cell cycle regulation Q14676 9656 6p21.33 human K45-m2 40190204 SGAHGPEkDFPLHLG molecular association, regulation; ubiquitination DNA repair, altered RNF8(DISRUPTS) 24240613 2 1 0 demethylation promotes ubiquitination -ITGA4 ITGA4 Cell adhesion; Membrane protein, integral; Motility/polarity/chemotaxis; Receptor, misc. P13612 3676 2q31.3 human S1011-p 7705801 FFKRQYKsILQEENR molecular association, regulation 14-3-3 zeta(INDUCES) 19401330 1 2 0 -MAP2K3 MKK3 EC 2.7.12.2; KINASE; Kinase, protein; Protein kinase, STE; Protein kinase, dual-specificity (non-receptor) P46734 5606 17p11.2 human S218-p 448276 ISGYLVDsVAKTMDA Pkinase enzymatic activity, induced transcription, induced; signaling pathway regulation 21878628; 8622669; 9162092 17 21 65 -NFE2 NF-E2 Cytoskeletal; DNA-binding; Transcription factor Q16621 4778 12q13.13 human K368-sm 2293701 FLVPRGTkMEATD__ molecular association, regulation transcription, induced DNA(INDUCES) 16287851 1 0 0 -Runx1 AML1 DNA-binding; Oncoprotein; Transcription factor Q03347 12394 16 C4|16 53.7 cM mouse S276-p 454401 VHPATPIsPGRASGM protein degradation; ubiquitination 24771859 13 11 70 -PRKN PARK2 EC 6.3.2.-; EC 6.3.2.19; Ligase; Translation; Translation regulation; UBIQUITIN LIGASE; Ubiquitin conjugating system; Ubiquitin ligase O60260 5071 6q26 human S9-p 11096954 IVFVRFNsSHGFPVE ubiquitin molecular association, regulation; ubiquitination; intracellular localization; phosphorylation carcinogenesis, inhibited; signaling pathway regulation RIPK3(INDUCES) 23256036; 31358971 3 1 1 binds to RIPK3 disrupting RIPK3-RIPK1 binding, induces RIPK3 ubiquitination, inhibits RIPK3 and MLKL phosphorylation, regulates RIPK3 localization, induces Parkin-RIPK3 pathway; S9, S10, S101 might be priming phosphorylation sites for S65 phosphorylarion -NRF1 NRF1 DNA-binding; Transcription factor Q16656 4899 7q32.2 human S136-p 23255800 QAIVLCIsPSKPNPV Nrf1_DNA-bind molecular association, regulation cell cycle regulation; transcription, altered DNA(DISRUPTS) 31350280 1 13 1 meiotic regulation -JAK2 JAK2 EC 2.7.10.2; KINASE; Kinase, protein; Oncoprotein; Protein kinase, TK; Protein kinase, tyrosine (non-receptor) O60674 3717 9p24.1 human Y1008-p 448408 LPQDKEYyKVKEPGE PK_Tyr_Ser-Thr activity, induced carcinogenesis, induced; cell motility, induced; cell growth, induced; cell adhesion, induced; apoptosis, inhibited; transcription, induced; signaling pathway regulation 22177802; 22508938; 34118143; 34162728; 34380633; 34642304; 34900727; 35296317; 36516775 77 2 16 -Stim1 STIM1 Calcium-binding; Endoplasmic reticulum; Membrane protein, integral P70302 20866 7 E2-E3|7 54.71 cM mouse S575-p 468876 LVEKLPDsPALAKKT molecular association, regulation; protein conformation ORAI1(INDUCES); EB1(INDUCES) 20736304; 23687376 9 69 13 calcium mobilization and EB1-dependent STIM1 multimerization ; regulate store operated calcium entry (SOCE) -EML3 EML3 Q32P44 256364 11q12.3 human T881-p 483690 GAGPAPAtPSRTPSL molecular association, regulation cell cycle regulation; chromatin organization, altered; cytoskeletal reorganization TUBG1(INDUCES); HAUS6(INDUCES); HAUS8(INDUCES) 30723163 1 23 14 important for EML3 interaction with Augmin and gamma-TuRC complexes and leads to microtubule nucleation and mitotic spindle assembly -Actr2 ARP2 Actin-binding; Cytoskeletal; Motility/polarity/chemotaxis P61161 66713 11 A3.1|11 12.88 cM mouse T237-p 36440502 EQKLALEtTVLVESY Actin intracellular localization 28947541 5 0 0 colocalization with F-actin (decreased in aging macrophages) -TNNI3 TNNI3 Actin-binding; Motility/polarity/chemotaxis; Motor P19429 7137 19q13.42 human S199-p 4707844 RKNIDALsGMEGRKK protein stabilization; molecular association, regulation; activity, inhibited ACTA1(DISRUPTS); TPM1(DISRUPTS) 24116014; 25771144 2 5 0 reduced maximal force generation; any alteration on S199 affect the sensitivity of TNNI3 to proteolysis -WASF2 WAVE2 Actin-binding; Motility/polarity/chemotaxis Q9Y6W5 10163 1p36.11 human S497-p 6377639 EFDEDDWsD______ activity, inhibited cytoskeletal reorganization 19012317 1 2 1 -UBA52-RPS27A-UBB-UBC ubiquitin Ubiquitin-like modifier P62988 2p16 human K48-ub 486303 QRLIFAGkQLEDGRT ubiquitin protein degradation; protein stabilization; molecular association, regulation; ubiquitination; intracellular localization; protein conformation cell cycle regulation; carcinogenesis, induced; carcinogenesis, inhibited; cell growth, inhibited; cell motility, inhibited; transcription, induced; transcription, altered; signaling pathway regulation; autophagy, induced; cell differentiation, induced; cell growth, induced; apoptosis, inhibited; cytoskeletal reorganization; transcription, inhibited; cell growth, altered ALDH2(INDUCES); Cezanne(INDUCES); ZO1(INDUCES); ubiquitin(INDUCES); occludin(INDUCES); nsp3-pp1a-pp1ab(INDUCES); TAB2(INDUCES); NPL4(INDUCES); ADRM1(INDUCES); GRP78(INDUCES); PSMD5(INDUCES) 18326498; 18613717; 18724939; 19858201; 19935683; 2174883; 26471729; 29378950; 30647455; 30714168; 30867293; 31042464; 31076633; 31167788; 31346036; 31366726; 31413110; 31451788; 31534008; 31548378; 31796886; 31802035; 31900278; 31937588; 32076268; 32160516; 32164484; 32366851; 32575755; 32845033; 33082516; 33196940; 33565245; 33568778; 34220184; 35064336; 35110531; 35354308; 35474067; 35638730; 35732617; 35770730; 35843886; 35858925; 36115849; 36261549; 36291162; 8576261 109 50 157 -Aqp2 AQP2 Channel, misc.; Membrane protein, integral; Membrane protein, multi-pass; Transporter; Transporter, aquaporin family P56402 11827 15 F1|15 56.13 cM mouse S256-p 449854 REVRRRQsVELHSPQ activity, induced; protein stabilization; molecular association, regulation; intracellular localization; receptor internalization, inhibited; phosphorylation exocytosis, altered; endocytosis, altered 14-3-3 theta(INDUCES); 14-3-3 zeta(INDUCES); ANXA2(DISRUPTS); HSC70(DISRUPTS); ACTG1(DISRUPTS) 16641094; 18606813; 19144687; 19966308; 24876223; 26645691 78 9 0 -HNRNPD hnRNP D0 RNA splicing; RNA-binding Q14103 3184 4q21.22 human K218-m1 58123002 IELPMDNkTNKRRGF RRM_1 molecular association, regulation L3MBTL iso4(INDUCES) 23583077 0 1 0 -EZR Ezrin Cytoskeletal; Motility/polarity/chemotaxis P15311 7430 6q25.3 human Y478-p 454875 PPPPPPVyEPVSYHV molecular association, regulation; intracellular localization; phosphorylation carcinogenesis, induced; cell motility, induced; cell motility, inhibited; cell adhesion, inhibited; signaling pathway regulation; cell growth, induced; cell motility, altered; cytoskeletal reorganization WWOX(INDUCES); Fes(INDUCES); KCTD15(INDUCES) 15623525; 16438931; 18046454; 21666723; 25231728; 27435765; 34375550 10 4 137 -Trpc6 TRPC6 Channel, cation; Membrane protein, integral; Membrane protein, multi-pass Q61143 22068 9 A1|9 2.46 cM mouse T69-p 470868 RLTHRRQtILREKGR activity, inhibited cell motility, inhibited 18617565; 20177073; 20448219; 23814119; 24740790; 36068079 11 2 6 -Rad52 RAD52 DNA repair, damage P43352 19365 6 F1|6 56.86 cM mouse Y105-p 449061 DLNNGKFyVGVCAFV Rad52_Rad22 molecular association, regulation DNA repair, inhibited RAD52(DISRUPTS) 33440161 4 0 0 -PRKD1 PRKD1 Autophagy; EC 2.7.11.13; KINASE; Kinase, protein; Motility/polarity/chemotaxis; Protein kinase, CAMK; Protein kinase, Ser/Thr (non-receptor) Q15139 5587 14q12 human Y95-p 764000 KFPECGFyGMYDKIL molecular association, regulation; enzymatic activity, induced PKCD(INDUCES) 17804414 3 0 0 -H2bc15 H2B DNA-binding P10853 319187 13|13 A3.1 mouse S36-p 449903 RKRSRKEsYSVYVYK Histone transcription, induced 20647423 7 13 47 S37 phosphorylation essential for cell survival in response to metabolic stress. -RAD17 RAD17 Cell cycle regulation O75943 5884 5q13.2 human T633-p 31894301 EESLGEPtQATVPET molecular association, regulation; phosphorylation carcinogenesis, induced; DNA repair, induced; signaling pathway regulation NBS1(INDUCES) 24534091 1 0 0 Phosphorylated RAD17 at T633 but not the T633A mutant, restores phosphorylation of ATM, CHK2 and NBS1. -SLC8B1 SLC24A6 Calcium-binding; Endoplasmic reticulum; Membrane protein, integral; Membrane protein, multi-pass; Transporter; Transporter, SLC family Q6J4K2 80024 12q24.13 human S258-p 50596805 YQRQRRGsLFCPMPV activity, induced 36476859 2 1 0 -DEK DEK DNA replication; DNA-binding; Histone-binding; Oncoprotein; RNA splicing P35659 7913 6p22.3 human T15-p 36122127 AEGEGTPtQPASEKE protein degradation; molecular association, regulation RNA splicing, induced FBXW7(INDUCES) 21282377 1 3 0 regulates tropomyosin alternative splicing -ESR1 ER-alpha DNA-binding; Nuclear receptor; Transcription factor P03372 2099 6q25.1-q25.2 human Y52-p 12620701 DSSKPAVyNYPEGAA Oest_recep protein stabilization carcinogenesis, induced; cell growth, induced; transcription, induced 20101225 1 0 0 -PLAG1 PLAG1 C2H2-type zinc finger protein; DNA-binding; Oncoprotein; Transcription factor Q6DJT9 5324 8q12.1 human K353-sm 3568002 PEKEQPLkGEIESYL intracellular localization cell growth, induced; transcription, inhibited 16207715 1 0 0 -ALDOB ALDOB Carbohydrate Metabolism - fructose and mannose; Carbohydrate Metabolism - glycolysis and gluconeogenesis; Carbohydrate Metabolism - pentose phosphate pathway; EC 4.1.2.13; KINASE; Lyase P79226 100328925 rabbit Y362-p 451309 QSLFTASyTY_____ Glycolytic enzymatic activity, inhibited 2275541 1 0 1 -MBD4 MBD4 Apoptosis; DNA repair, damage; Deoxyribonuclease; EC 3.2.2.- O95243 8930 3q21.3 human S262-p 22730000 SGFVQSDsKRESVCN enzymatic activity, induced DNA repair, induced 19829383 1 0 0 -CKMT2 CKMT2 Amino Acid Metabolism - arginine and proline; EC 2.7.3.2; Kinase, other; Mitochondrial P17540 1160 5q14.1 human Y368-p 478453 TAAVADVyDISNIDR ATP-gua_Ptrans enzymatic activity, induced transcription, induced; signaling pathway regulation 34095014 1 5 96 induces PGC-1a/estrogen-related receptor-a pathway -Dbnl DBNL Actin-binding; Motility/polarity/chemotaxis Q62418 13169 11 A1|11 3.87 cM mouse Y340-p 450090 QTEEEPTyEVPPEQD cell motility, induced; cytoskeletal reorganization; cell motility, inhibited 22303001; 30504273 4 1 27 cell migration to CP; extracellular matrix degradation, inhibits invasive cell migration -FOXO3 FOXO3A Autophagy; DNA-binding; Oncoprotein; Transcription factor O43524 2309 6q21 human K259-ac 460594 VSMDNSNkYTKSRGR protein stabilization; molecular association, regulation; ubiquitination apoptosis, induced; transcription, induced JNK1(INDUCES); SKP2(DISRUPTS) 21841822; 27669435 5 1 0 -MLYCD MLYCD Carbohydrate Metabolism - propanoate; EC 4.1.1.9; Lyase; Other Amino Acids Metabolism - beta-alanine O95822 23417 16q23.3 human Y405-p 41196501 LMRLCAWyLYGEKHR MCD protein conformation; enzymatic activity, induced 26004805 1 0 0 -SLC12A2 NKCC1 Membrane protein, integral; Membrane protein, multi-pass; Transporter; Transporter, SLC family P55011 6558 5q23.3 human T203-p 467235 HQHYYYDtHTNTYYL AA_permease_N activity, induced; enzymatic activity, induced 16669787; 22032326 11 1 0 -CASP8 CASP8 Apoptosis; EC 3.4.22.61; Protease Q14790 841 2q33.1 human T263-p 21258500 SIRDRNGtHLDAGAL Peptidase_C14 protein degradation; ubiquitination apoptosis, inhibited 21183680 2 1 0 -Smad3 SMAD3 DNA-binding; Nuclear receptor co-regulator; Transcription factor Q8BUN5 17127 9|9 C mouse S423-p 448335 SPSIRCSsVS_____ molecular association, regulation; intracellular localization carcinogenesis, induced; cell growth, induced; cell motility, induced; cell growth, inhibited; cell differentiation, induced; transcription, induced SMAD4(INDUCES) DNA(INDUCES) 30042129; 32122971; 34799661; 37350664 39 0 5 -CIP2A CIP2A Membrane protein, integral Q8TCG1 57650 3q13.13 human S904-p 482834 NPETVNLsI______ molecular association, regulation; intracellular localization cell cycle regulation; cytoskeletal reorganization 14-3-3 eta(INDUCES) 28935709; 36255265 2 11 0 MTOC localization -ESR1 ER-alpha DNA-binding; Nuclear receptor; Transcription factor P03372 2099 6q25.1-q25.2 human S118-p 448101 LHPPPQLsPFLQPHG Oest_recep activity, induced; protein degradation; acetylation; molecular association, regulation; phosphorylation carcinogenesis, induced; carcinogenesis, altered; cell growth, induced; transcription, induced; signaling pathway regulation; transcription, altered; cell growth, altered Src(INDUCES); SRC-2(INDUCES); TCF20(INDUCES); CBP(INDUCES); ERK2(INDUCES); SRC-3(INDUCES); PPP5C(INDUCES); SF3A1(INDUCES); P38A(INDUCES) DNA(INDUCES) 11108261; 11139588; 12093745; 12714702; 14764652; 15059947; 15461668; 15528270; 15778291; 15808510; 15831449; 15879307; 15919818; 16076840; 16113102; 16452229; 17068199; 17615152; 18372406; 19169277; 19339517; 19887647; 19940281; 23390529; 23850489; 23861392; 25531331; 27748765; 28423697; 31120927; 33542078; 34711683; 34810200; 36516775; 36915147; 37285115 93 2 0 -Mcl1 MCL1 Apoptosis; Channel, misc.; Inhibitor; Membrane protein, integral; Mitochondrial P97287 17210 3 F2.1|3 40.74 cM mouse K117-ub 10843917 CEPEAIGkRPAVLPL protein degradation; molecular association, regulation; ubiquitination autophagy, induced beclin 1(DISRUPTS) 28053206 2 2 10 -HAUS8 HAUS8 Cell cycle regulation Q9BT25 93323 19p13.11 human S131-p 20609207 SKKPESTsFSAPRKK intracellular localization cell cycle regulation; apoptosis, inhibited 21690413 1 3 0 localization to the spindle -Pou5f1 Oct4 DNA-binding; Transcription factor P20263 18999 17 B1|17 18.69 cM mouse K137-ub 15496419 QDMKALQkELEQFAK Pou protein degradation 32895487 1 0 1 -Nfe2l2 NRF2 DNA-binding; Transcription factor O54968 83619 3q23 rat S40-p 450082 SREVFDFsQRQKDYE activity, induced; molecular association, regulation; intracellular localization transcription, induced; transcription, altered KEAP1(DISRUPTS); p21Cip1(INDUCES) 12198130; 35842499 33 0 0 -Mark2 MARK2 EC 2.7.11.1; EC 2.7.11.26; KINASE; Kinase, protein; Protein kinase, CAMK; Protein kinase, Ser/Thr (non-receptor) O08679 60328 1q43 rat T208-p 449999 TFGNKLDtFCGSPPY Pkinase enzymatic activity, induced 14517247; 9108484 11 48 47 -NOTCH1 Notch 1 Membrane protein, integral; Motility/polarity/chemotaxis; Oncoprotein; Receptor, misc.; Transcription factor P46531 4851 9q34.3 human S2513-p 35483201 EHPFLTPsPESPDQW protein degradation; molecular association, regulation; ubiquitination carcinogenesis, inhibited FBXW7(INDUCES) 25344755 1 1 0 -ADRB2 ADRB2 GPCR, family 1; Membrane protein, integral; Membrane protein, multi-pass; Receptor, GPCR P07550 154 5q32 human S411-p 457444 RNCSTNDsLL_____ molecular association, regulation; protein conformation NHERF(DISRUPTS) 10499588; 21868357 5 1 0 -ANAPC1 APC1 Cell cycle regulation; Ubiquitin conjugating system Q9H1A4 64682 2q13 human S372-p 483446 GVQRFNIsSHNQSPK activity, induced 27120157 1 11 0 -RCHY1 RCHY1 EC 6.3.2.-; EC 6.3.2.19; Nuclear receptor co-regulator; UBIQUITIN LIGASE; Ubiquitin conjugating system; Ubiquitin ligase Q96PM5 25898 4q21.1 human T217-p 27971903 PSEYQNMtVDILCND zinc_ribbon_6 ubiquitination; activity, inhibited transcription, inhibited 23603988 1 0 0 self-ubiquitination, may contribute to p53-inhibition of transcriptional elongation of HIV-LTR -Map2 MAP2 iso3 Cytoskeletal; Motility/polarity/chemotaxis P15146-3 25595 9q32 rat K316-ac 62495512 DLKNVKSkIGSTDNI Tubulin-binding cytoskeletal reorganization 28002468 1 1 0 -PLK1 PLK1 EC 2.7.11.21; KINASE; Kinase, protein; Protein kinase, Other; Protein kinase, Ser/Thr (non-receptor) P53350 5347 16p12.2 human K413-me 1877571001 IPIFWVSkWVDYSDK enzymatic activity, inhibited cell cycle regulation; cell growth, inhibited 30622182 1 1 0 -CTNNA1 CTNNA1 Actin-binding; Motility/polarity/chemotaxis P35221 1495 5q31.2 human Y177-p 457896 EQDLGIQyKALKPEV Vinculin activity, induced; molecular association, regulation APC(DISRUPTS) 24240237 1 14 576 enhances B-catenin transactivation -BCL2L1 Bcl-xL Apoptosis; Autophagy; Membrane protein, integral; Mitochondrial Q07817 598 20q11.21 human T47-p 448163 GTESEMEtPSAINGN cell cycle regulation; apoptosis, altered; apoptosis, induced CDK1(DISRUPTS) 10617621; 17369848 4 0 0 A peptide surrounding T47 and S62 phosphorylation sites impeded inhibition of CDK1. apoptotoc function of bcl-xl was not affected. -CEACAM1 CEACAM1 iso8 Cell adhesion; Immunoglobulin superfamily; Membrane protein, integral; Motility/polarity/chemotaxis P13688-8 634 19q13.2 human S459-p 3439800 LHFGKTGsSGPLQ__ phosphorylation cell differentiation, altered 17546042 3 1 0 FAK Y397 phosphorylation -DDX21 DDX21 EC 3.6.4.13; Helicase; Nucleolus; RNA processing; RNA-binding Q9NR30 9188 10q22.1 human K137-ac 41518316 PKKMKKEkEMNGETR enzymatic activity, inhibited transcription, inhibited 28790157 1 1 0 Inhibits DDX21 helicase activity, impairs genomic stability, R-loop mediated stalling of RNA polymerase -Ahcyl1 AHCYL1 Amino Acid Metabolism - cysteine and methionine; EC 3.3.1.1; Hydrolase; Other Amino Acids Metabolism - selenoamino acid Q80SW1 229709 3 F2.3|3 46.83 cM mouse T72-p 467248 RSISQSStDSYSSAA molecular association, regulation IP3R1(INDUCES) 16793548 1 0 1 binding to IP3R1 supresses its binding to IP3 and inhibits IP3-induced calcium release -Crem CREM DNA-binding; Transcription factor P27699 12916 18|18 A1 mouse S284-p 450065 QGVVMAAsPGSLHSP activity, inhibited transcription, altered 8114763 3 14 2 -Gata1 GATA1 DNA-binding; Transcription factor P17679 14460 X A1.1|X 3.59 cM mouse S49-p 451233 DAASSSTsPNAATAA protein degradation; acetylation; ubiquitination; phosphorylation DNA(INDUCES) 16858405 2 0 0 Phosphorylation and acetylation cause the degradation of acetylated GATA-1; DNA binding is required for MAPK-dependent phosphorylation -kif2c KIF2C Cancer Testis Antigen (CTA); Microtubule-binding; Motility/polarity/chemotaxis; Motor Q91636 380006 frog S719-p 3545002 LQVEEQAsKQISKKK intracellular localization cytoskeletal reorganization 18434591 2 0 0 facilitates bipolar spindle formation -MYC Myc DNA-binding; Nucleolus; Oncoprotein; Transcription factor P01106 4609 8q24.21 human K341-ub 40850501 YPAAKRVkLDSVRVL Myc_N protein degradation; ubiquitination 25944903 1 1 0 degradation induced by FBXO32 -DLX3 DLX3 DNA-binding; Transcription factor O60479 1747 17q21.33 human K112-sm 25344508 AQDPVSVkEEPEAEV transcription, induced 21268066 1 0 0 -ESR1 ER-alpha DNA-binding; Nuclear receptor; Transcription factor P03372 2099 6q25.1-q25.2 human S106-p 448100 PLNSVSPsPLMLLHP Oest_recep activity, induced; molecular association, regulation carcinogenesis, induced; cell motility, induced; cell growth, induced; transcription, induced; transcription, altered Src(INDUCES); SRC-2(INDUCES); SRC-3(INDUCES); CBP(INDUCES) DNA(INDUCES) 11108261; 12714702; 16076840; 18372406; 23861392; 25531331; 26522726; 33542078 25 1 0 -KRAS KRas G protein; G protein, monomeric; G protein, monomeric, Ras; Motility/polarity/chemotaxis; Oncoprotein P01116 3845 12p12.1 human Y32-p 15228779 QNHFVDEyDPTIEDS Ras molecular association, regulation; protein conformation; activity, inhibited; phosphorylation signaling pathway regulation BRAF(DISRUPTS) 30644389; 34725361 2 5 8 regulates MAPK signaling -RIGI RIGI EC 3.6.4.13; Hydrolase O95786 23586 9p21.1 human T770-p 17484200 DSILRLQtWDEAVFR molecular association, regulation; enzymatic activity, inhibited RIGI(DISRUPTS) 21068236 2 2 0 dephosphorylation of T770, S855, S854 stimulates multimer formation; -VIM Vimentin Cytoskeletal; Motility/polarity/chemotaxis P08670 7431 10p13 human S412-p 451764 EGEESRIsLPLPNFS protein stabilization 36393840 3 35 11 -Atf1 ATF-1 Transcription factor P81269 11908 15|15 F1 mouse S41-p 15725600 SLSESEEsQDSSDSI molecular association, regulation cell growth, induced; transcription, induced HSF1(INDUCES) 25312646 2 0 0 HSP70 expression, increases cell survival -RBBP8 CtIP EC 3.1.-.-; Transcription, coactivator/corepressor Q99708 5932 18q11.2 human T315-p 4766297 FSDSTSKtPPQEELP protein degradation; molecular association, regulation; ubiquitination; enzymatic activity, induced; phosphorylation DNA repair, altered PIN1(INDUCES) 23623683; 24837676 2 13 1 inhibits phosphorylation of RPA2 -Lpcat1 LPCAT1 ACETYLTRANSFERASE; Acetyltransferase; EC 2.3.1.23; EC 2.3.1.67; Endoplasmic reticulum; Membrane protein, integral Q3TFD2 210992 13|13 C1 mouse S178-p 17533100 RPVFVSRsDQDSRRK Acyltransferase protein degradation; ubiquitination 21068446 1 0 0 -Git1 GIT1 GAP; GAP, ARF; Motility/polarity/chemotaxis Q68FF6 216963 11|11 B5 mouse Y330-p 15702200 FLPVNPEySATRNQG molecular association, regulation transcription, induced; signaling pathway regulation ERK2(INDUCES); ERK1(INDUCES) 22797318 4 0 0 VEGF expression and fracture healing -RPS6 S6 Translation P62753 6194 9p22.1 human S244-p 448095 LRASTSKsESSQK__ carcinogenesis, induced; carcinogenesis, inhibited; apoptosis, induced; apoptosis, inhibited; autophagy, inhibited; signaling pathway regulation 34762647; 36149602; 36715448; 37624695 108 34 561 -AGO2 AGO2 EC 3.1.26.n2; RNA processing; RNA-binding Q9UKV8 27161 8q24.3 human S387-p 472450 SKLMRSAsFNTDPYV ArgoL2 molecular association, regulation; enzymatic activity, inhibited; intracellular localization exocytosis, inhibited; RNA stability, inhibited; translation, inhibited TNRC6A(INDUCES); LIMD1(INDUCES) 18476811; 23603119; 27117408; 28683311; 30154469; 34117353 8 22 20 miRNA-mediated repression, downregulating cleavage of endogenous miRNA-targeted mRNAs, P body localization of Ago2; recruitmentof miR-4312 and competes HuR to bind to IL-8 transcrip; inhibits Ago2 association with multivesicular endosomes (MVEs), and diminishes secretion into exosomes -ANPEP CD13 EC 3.4.11.2; Membrane protein, integral; Other Amino Acids Metabolism - glutathione; Protease; Receptor, misc. P15144 290 15q26.1 human S43-p 1870824600 EKNKNANsSPVASTT molecular association, regulation 14-3-3 sigma(INDUCES) 33109610 1 0 0 -HAUS8 HAUS8 Cell cycle regulation Q9BT25 93323 19p13.11 human T130-p 7322606 ISKKPEStSFSAPRK intracellular localization cell cycle regulation; apoptosis, inhibited 21690413 1 1 0 localization to the spindle -GAPDH GAPDH Carbohydrate Metabolism - glycolysis and gluconeogenesis; EC 1.2.1.12; Oxidoreductase P04406 2597 12p13.31 human K117-ac 474648 AHLQGGAkRVIISAP intracellular localization 20601085 1 0 127 nuclear translocation -NCF1 p47phox EC 1.-.-.-; Oxidoreductase P14598 653361 7q11.23 human S345-p 451727 QARPGPQsPGSPLEE activity, induced; molecular association, regulation; intracellular localization; enzymatic activity, induced; phosphorylation cell growth, induced; signaling pathway regulation ROCK2(INDUCES) 16778989; 22460559; 31736979; 31811262; 33388549 23 7 0 -LTB4R LTB4R GPCR, family 1; Membrane protein, integral; Membrane protein, multi-pass; Receptor, GPCR Q15722 1241 14q12 human T315-p 4700736 TGSEASStRRGGSLG receptor internalization, induced; phosphorylation signaling pathway regulation 22707565; 30131369 2 2 0 phosphorylation of LTB4R basal phosphorylation site; enhanced ligand-induced internalization ; chemotaxis, B-hexisaminidase release, regulates LTB4R function -Irf3 IRF3 DNA-binding; Transcription factor P70671 54131 7|7 B3 mouse K152-sm 3278900 GLILGPLkDEGSSDL transcription, inhibited 18635538 2 0 0 -MYC Myc DNA-binding; Nucleolus; Oncoprotein; Transcription factor P01106 4609 8q24.21 human S96-p 28850303 YVAVTPFsLRGDNDG Myc_N carcinogenesis, inhibited; transcription, inhibited 24030976 1 2 0 -Sik1 SIK EC 2.7.11.1; KINASE; Kinase, protein; Motility/polarity/chemotaxis; Protein kinase, CAMK; Protein kinase, Ser/Thr (non-receptor); Tumor suppressor Q9R1U5 59329 20p12 rat S186-p 2560900 PLSTWCGsPPYAAPE Pkinase molecular association, regulation; enzymatic activity, induced 14-3-3 beta(INDUCES) 18348280 2 0 0 important for TORC2 phosphorylation and activation -PIK3C2A PIK3C2A Autophagy; Carbohydrate Metabolism - inositol phosphate; EC 2.7.1.154; KINASE; Kinase, lipid; Motility/polarity/chemotaxis O00443 5286 11p15.1 human S259-p 449059 KVSNLQVsPKSEDIS protein degradation; protein conformation 12719431 1 44 3 -TRIM32 TRIM32 EC 6.3.2.-; EC 6.3.2.19; Ligase; UBIQUITIN LIGASE; Ubiquitin conjugating system; Ubiquitin ligase Q13049 22954 9q33.1 human K247-ac 1873117010 DYFLAKIkQADVALL protein degradation; intracellular localization autophagy, induced 33999923 1 0 0 -HIPK2 HIPK2 EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, CMGC; Protein kinase, Ser/Thr (non-receptor) Q9H2X6 28996 7q34 human T119-p 28847903 HNLMRRStVSLLDTY protein stabilization; molecular association, regulation; phosphorylation; enzymatic activity, induced PPM1D(DISRUPTS) 23871434 1 0 0 increase protein stabilization and reduce phosphorylation of WIP1 -KCNMA1 KCNMA1 Channel, potassium; Endoplasmic reticulum; Membrane protein, integral; Membrane protein, multi-pass Q12791 3778 10q22.3 human S978-p 456598 PPGMDRSsPDNSPVH activity, induced 11078709 1 4 0 -Cd19 CD19 Cell surface; Membrane protein, integral P25918 12478 7 F3|7 69.01 cM mouse Y522-p 447639 HEEDADSyENMDKSD activity, induced; molecular association, regulation cell differentiation, altered PIK3R1(INDUCES) 12387743; 18025150 8 3 18 regulate Akt activation and B-cell differentiation through binding to PI3KR1 -GSK3B GSK3B EC 2.7.11.1; EC 2.7.11.26; KINASE; Kinase, protein; Protein kinase, CMGC; Protein kinase, Ser/Thr (non-receptor) P49841 2932 3q13.33 human T390-p 452320 RIQAAAStPTNATAA enzymatic activity, induced signaling pathway regulation 18451303; 21303975 6 15 13 epithelial to mesenchymal transition (EMT) -PPP1R12A MYPT1 Motility/polarity/chemotaxis; PHOSPHATASE; Protein phosphatase, regulatory subunit O14974 4659 12q21.2-q21.31 human T577-gl 1868585004 TTSTPTVtSAAGLQK molecular association, regulation; phosphorylation cell cycle regulation PLK1(DISRUPTS) 32295844 1 1 0 inhibits CDK1-dependent phosphorylation at MYPT1 S473, regulates mitotic progression and centrosome integrity -XRCC2 XRCC2 O43543 7516 7q36.1 human S247-p 482708 FFSKQDDsQSSNQFS Rad51 DNA repair, altered 30566856 1 1 0 XRCC2 phosphorylation is involved in regulation of fork progression (slowing) during dNTP alterations -Kat5 Tip60 ACETYLTRANSFERASE; Acetyltransferase; EC 2.3.1.48; Nuclear receptor co-regulator; Nucleolus Q8CHK4 81601 19|19 A mouse S86-p 448826 TKNGLPGsRPGSPER apoptosis, induced 25858503 7 31 5 -FUS hnRNP P2 DNA-binding; Nuclear receptor co-regulator; Oncoprotein; RNA splicing; RNA-binding; SUMO LIGASE P35637 2521 16p11.2 human S462-p 18801758 PGGGPGGsHMGGNYG molecular association, regulation hnRNP P2(DISRUPTS) 35753345 1 7 1 -PEBP1 RKIP Lipid-binding; Protein kinase, regulatory subunit P30086 5037 12q24.23 human S153-p 448755 RGKFKVAsFRKKYEL PBP molecular association, regulation; receptor desensitization, altered; intracellular localization; receptor internalization, altered; phosphorylation RAF1(DISRUPTS); GRK2(INDUCES) 14654844; 17170028; 36805338 9 16 1 -MITF MITF iso9 DNA-binding; Oncoprotein; Transcription factor O75030-9 4286 3p13 human K182-sm 3590701 PANLPNIkRELTACI transcription, inhibited 15507434 3 1 0 -SLX4 SLX4 DNA repair, damage; Deoxyribonuclease Q8IY92 84464 16p13.3 human T1544-p 1880104206 QKPEGLEtPKGANRK molecular association, regulation; protein conformation MUS81(INDUCES) 36288699 1 1 0 -TP53BP2 53BP2 Transcription, coactivator/corepressor Q13625 7159 1q41 human S827-p 30995203 NSDMPAPsPGLDYEP intracellular localization apoptosis, induced; transcription, induced 24312625 1 1 0 necessary for Ras-induced translocation to the cytosol and nucleus, p53 mediated transcription and pro-apoptotic activity -GRIN2A NMDAR2A Channel, ligand-gated; Membrane protein, integral; Membrane protein, multi-pass Q12879 2903 16p13.2 human Y1292-p 4109565 RISRQHSyDNIVDKP NMDAR2_C activity, induced 33037073 3 1 16 leptin-induced beta-cell membrane potentiation -FPR1 FPR1 GPCR, family 1; Membrane protein, integral; Membrane protein, multi-pass; Motility/polarity/chemotaxis; Receptor, GPCR P21462 2357 19q13.41 human S328-p 450847 ERALTEDsTQTSDTA molecular association, regulation; receptor desensitization, altered; receptor internalization, altered ARRB2(INDUCES) 10514456; 16622009 3 2 0 -ABL2 Arg EC 2.7.10.2; KINASE; Kinase, protein; Oncoprotein; Protein kinase, TK; Protein kinase, tyrosine (non-receptor) P42684 27 1q25.2 human Y272-p 456540 KCNKPTVyGVSPIHD enzymatic activity, induced 34144039 3 5 3 -Rb1 Rb Nuclear receptor co-regulator; Oncoprotein; Transcription, coactivator/corepressor; Tumor suppressor P13405 19645 14 38.73 cM|14 D3 mouse S786-p 17551329 PRSPYKFsSSPLRIP Rb_C cell cycle regulation; transcription, inhibited 9671466 1 1 0 transcriptional downregulation of the E2F-1, E2F-2, dihydrofolate reductase, thymidine kinase, c-myc, proliferating-cell nuclear antigen, p107, and p21/Cip1 genes -XPO1 Exportin-1 Karyopherin; Nuclear export; Nuclear import; Nucleolus O14980 7514 2p15 human S1055-p 453528 EKHKRQMsVPGIFNP activity, induced; intracellular localization autophagy, induced; signaling pathway regulation 31544310 1 8 69 Hippo signaling pathway; regulates subcellular localization (nuclear exit) of NDR1 (aka STK38), Beclin1 and YAP1 -ABI2 Abi-2 Adaptor/scaffold; Motility/polarity/chemotaxis Q9NYB9 10152 2q33.2 human S183-p 4710620 PPTQKPPsPPMSGKG protein stabilization carcinogenesis, induced; cell motility, induced; cytoskeletal reorganization 37042842 1 31 4 -DGCR8 DGCR8 Nucleolus; RNA processing; RNA-binding Q8WYQ5 54487 22q11.21 human S123-p 36129171 KDVKISVsFTESCRS protein stabilization 24239349 0 2 0 -NEK2 NEK2 EC 2.7.11.1; KINASE; Kinase, protein; Nucleolus; Protein kinase, Other; Protein kinase, Ser/Thr (non-receptor) P51955 4751 1q32.3 human T175-p 12574603 HDTSFAKtFVGTPYY Pkinase enzymatic activity, induced 17197699 1 2 0 -PTPRA PTPRA iso6 EC 3.1.3.48; Membrane protein, integral; Motility/polarity/chemotaxis; PHOSPHATASE; Receptor protein phosphatase, tyrosine P18433-2 5786 20p13 human S204-p 447612 PLLARSPsTNRKYPP molecular association, regulation; phosphorylation; enzymatic activity, induced cell growth, altered PIK3CB(INDUCES); Src(INDUCES); PKCD(INDUCES); GRB2(DISRUPTS) 11676480; 11923305; 23532252 6 3 1 promotes PTPRA tyrosine phosphorylation -RGS5 RGS5 GAP; GAP, RGS O15539 8490 1q23.3 human S166-p 482845 HALMEKDsLPRFVRS RGS activity, induced; molecular association, regulation G-alpha 13(DISRUPTS) 17540411 1 0 0 increase intracellular Ca2+; GTPase activating function -Cttn Cortactin Actin-binding; Cytoskeletal; Motility/polarity/chemotaxis Q60598 13043 7|7 F5 mouse S418-p 447701 IEDRPPSsPIYEDAA cell cycle regulation; cell motility, altered 18515860 15 90 197 -DCBLD2 DCBLD2 Cell adhesion; Membrane protein, integral Q96PD2 131566 3q12.1|3 human Y621-p 454599 LQADSAEyAQPLVGG molecular association, regulation CRKL(INDUCES) 23770091 2 17 87 -CCDC6 CCDC6 Apoptosis; Cytoskeletal; Oncoprotein Q16204 8030 10q21.2 human T427-p 4790792 PDKFKRPtPPPSPNT protein degradation; molecular association, regulation; phosphorylation cell cycle regulation; DNA repair, inhibited FBXW7(INDUCES) 23108047; 25885523; 35964058 3 1 1 inhibits H2AX phosphorylation -SET SET iso2 Apoptosis; DNA replication; DNA-binding; Inhibitor; Nuclear receptor co-regulator; Oncoprotein; Protein phosphatase, regulatory subunit Q01105-2 6418 9q34.11 human S93-p 19009801 FVNHPQVsALLGEED NAP receptor desensitization, induced; molecular association, regulation; phosphorylation signaling pathway regulation PPP2CA(INDUCES) 21419339 2 1 0 beta-2AR phosphorylation and signaling -PKD2L1 PKD2L1 Channel, cation; Membrane protein, integral; Membrane protein, multi-pass; Motility/polarity/chemotaxis Q9P0L9 9033 10q24.31 human T39-p 59032202 HGTLRVCtISSTGPL activity, inhibited 27754867 1 0 0 channel activity regulated independently of palmitoylation -PSIP1 LEDGF Motility/polarity/chemotaxis; Transcription, coactivator/corepressor O75475 11168 9p22.3 human K254-sm 13875715 EPDKKEGkKEVESKR protein degradation transcription, inhibited 20382164 1 0 0 -SLC12A5 KCC2 Membrane protein, integral; Membrane protein, multi-pass; Transporter; Transporter, SLC family Q9H2X9 57468 20q13.12 human T929-p 10045603 SAYTYEKtLVMEQRS SLC12 activity, inhibited 19665974 7 4 0 -FOXM1 FOXM1 DNA-binding; Transcription factor Q08050 2305 12p13.33 human S638-p 10897610 KVGGLDFsPVQTSQG protein stabilization transcription, induced 22094256 2 6 0 -RBM39 RNPC2 Nuclear receptor co-regulator; RNA-binding; Spliceosome Q14498 9584 20q11.22 human Y95-p 3196190 DRRFRGRyRSPYSGP transcription, induced 27018250 1 15 12 expression of ER (or PR) responsive genes -Oprm1 MOR-1 GPCR, family 1; Membrane protein, integral; Membrane protein, multi-pass; Receptor, GPCR P33535 25601 1q11 rat T370-p 447785 STRVRQNtREHPSTA molecular association, regulation; receptor desensitization, altered; receptor internalization, altered; phosphorylation ARR3(INDUCES); ARRB2(INDUCES) 11278523; 12860981; 18558479; 23106126 19 5 0 -KRT18 K18 Cytoskeletal; Nucleolus P05783 3875 12q13.13 human S30-gl 6778602 SYGARPVsSAASVYA phosphorylation apoptosis, inhibited 20729838 3 0 0 K18?Gly? mutation alters protein kinase phosphorylation and promotes apoptosis in response to STZ treatment; Akt1 Thr 308 phosphorylation increased 12 h after STZ treatment in livers of mice expressing wild-type K18, but in K18?Gly? inhibits Akt1 Thr 308 phosphorylation; glycosylation promotes th the phosphorylation and activation of cell-survival kinases -IWS1 IWS1 Transcription factor Q96ST2 55677 2q14.3 human T721-p 1851496 QRRRMNStGGQTPRR molecular association, regulation; intracellular localization carcinogenesis, induced; RNA splicing, induced; cell motility, induced THOC4(DISRUPTS); SPT6(DISRUPTS) 24462114 1 4 79 recruitment of SetD2 to RNA Pol II elongation complex, regulates alternative splicing -Sox2 SOX2 Cell development/differentiation; DNA-binding; Transcription factor P48432 20674 3 A3|3 16.93 cM mouse T118-p 17490601 KYRPRRKtKTLMKKD SOXp activity, induced; protein stabilization transcription, induced 20945330 2 0 0 plays a crucial role in somatic cell reprogramming -CHEK2 Chk2 EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, CAMK; Protein kinase, Ser/Thr (non-receptor); Tumor suppressor O96017 11200 22q12.1 human T378-gl 1872610001 HSKILGEtSLMRTLC Pkinase protein stabilization carcinogenesis, induced; cell growth, induced 33690219 1 0 0 -RAB29 RAB29 G protein; G protein, monomeric; G protein, monomeric, Rab O14966 8934 1q32.1 human S72-p 396518800 AGQERFTsMTRLYYR Ras activity, inhibited 29212815 2 0 0 Rab29 phosphorylation may decrease its ability to activate LRRK2 -AFAP1 AFAP Adaptor/scaffold Q8N556 60312 4p16.1 human Y94-p 3891001 SSLPEGYyEEAVPLS molecular association, regulation Src(INDUCES) 9655255 1 2 4 Src Y529F Src mutant -SUPT5H SPT5 RNA-binding; Transcription, coactivator/corepressor O00267 6829 19q13.2 human T806-p 458819 TPHYGSQtPLHDGSR transcription, altered 16427012 2 12 68 required for c-fos induction and activation in vivo -FBXO31 FBXO31 Cell cycle regulation; UBIQUITIN LIGASE; Ubiquitin conjugating system; Ubiquitin ligase Q5XUX0 79791 16q24.2 human S33-p 485583 AETAAADsEPDTDPE protein degradation; ubiquitination 29343641 1 11 4 -MDC1 MDC1 Cell cycle regulation Q14676 9656 6p21.33 human T847-p 30996100 PERQTDVtGEEELTK molecular association, regulation cell cycle regulation TOP2A(DISRUPTS) 24349352 1 0 0 -Fxyd1 PLM Cell surface; Channel, misc.; Membrane protein, integral O08589 58971 1q21 rat S88-p 451425 RSSIRRLsTRRR___ activity, induced; molecular association, regulation; activity, inhibited ZDHHC5(INDUCES) 16434394; 17283221; 19339511; 21849407; 25422474 27 3 74 -Dnm1 DYN1 EC 3.6.5.5; Hydrolase; Microtubule-binding; Motility/polarity/chemotaxis; Motor; Vesicle P21575 140694 3p12 rat Y231-p 447605 LLPLRRGyIGVVNRS Dynamin_M molecular association, regulation; receptor internalization, altered; activity, inhibited; protein conformation 12011079; 9880482 2 2 0 Y231/597F mutant Inhibits B2-AR internalization, and inhibited the isoproterenol mediated activation of ERK2.; Tyrosine phosphorylation promotes DYN1 self assembly. -Rora RORA DNA-binding; Nuclear receptor P51448 19883 9 C|9 37.45 cM mouse S100-p 1212279800 CKGFFRRsQQSNATY zf-C4 molecular association, regulation transcription, induced HNF4 alpha(INDUCES); CaR(INDUCES) DNA(INDUCES) 31924695 4 1 0 -MAPT Tau iso8 ACETYLTRANSFERASE; Acetyltransferase; Cytoskeletal P10636-8 4137 17q21.31 human S356-p 449104 RVQSKIGsLDNITHV Tubulin-binding molecular association, regulation; intracellular localization; protein conformation cytoskeletal reorganization 10090741; 17725643; 21204788; 34936879; 36004506 35 24 0 -RUNX1 AML1 iso8 DNA-binding; Oncoprotein; Transcription factor Q01196-8 861 21q22.12 human S462-p 454402 AEGSHSNsPTNMAPS RunxI cell differentiation, induced 22531928 3 2 0 -IKZF1 Ikaros C2H2-type zinc finger protein; DNA-binding; Transcription factor Q13422 10320 7p12.2 human K241-sm 3609103 GTLYPVIkEETNHSE carcinogenesis, induced; cell growth, induced 27315244 2 0 0 -MAPT Tau iso8 ACETYLTRANSFERASE; Acetyltransferase; Cytoskeletal P10636-8 4137 17q21.31 human S285-p 487455 INKKLDLsNVQSKCG Tubulin-binding molecular association, regulation; protein conformation Tau(INDUCES) 36003083 2 3 0 -Akt2 Akt2 EC 2.7.11.1; KINASE; Kinase, protein; Oncoprotein; Protein kinase, AGC; Protein kinase, Ser/Thr (non-receptor) Q60823 11652 7 A3|7 15.94 cM mouse S474-p 448520 RTHFPQFsYSASIRE Pkinase_C transcription, induced 34704268 37 9 55 -CD79B Ig-beta Membrane protein, integral; Receptor, misc. P40259 974 17q23.3 human K219-ub 12312067 TLRTGEVkWSVGEHP intracellular localization 32127472 1 1 11 in cytoplasm -TUFT1 TUFT1 Q9NNX1 7286 1q21.3 human K79-sm 1883375202 DGHEEIIkVYLKGRS carcinogenesis, induced; cell motility, induced; cell growth, induced 36380570 1 0 0 -CERS3 LASS3 DNA-binding; EC 2.3.1.24; Membrane protein, integral; Membrane protein, multi-pass Q8IU89 204219 15q26.3 human S340-p 17545395 KSIQDVRsDDEDYEE enzymatic activity, induced 26887952 1 2 1 -H3F3C H3 DNA-binding P84229 427887 chicken S10-p 455676 TKQTARKsTGGKAPR Histone molecular association, regulation chromatin organization, altered; transcription, induced DNA(INDUCES) 17913747 241 15 1 -BAX BAX Apoptosis; Membrane protein, integral; Mitochondrial; Tumor suppressor Q07812 581 19q13.33 human S184-p 451017 VAGVLTAsLTIWKKM TM activity, induced; protein degradation; molecular association, regulation; intracellular localization; activity, inhibited carcinogenesis, induced; cell growth, induced; apoptosis, inhibited FBXL20(INDUCES) 15642728; 17911107; 34587475; 35250564; 37324940 9 0 0 -FTO FTO DEMETHYLASE; Demethylase; EC 1.14.11.- Q9C0B1 79068 16q12.2 human K216-ub 22244732 PQKMPYLkEEPYFGM FTO_NTD protein degradation carcinogenesis, induced 34218271 1 6 0 hypoxic tumor microenvironment promotes hypoxic tumor microenvironment promotes CRC metastasis; FTO exerts a tumor suppressive effect -Star STAR Carrier; Lipid-binding; Mitochondrial P70114 101844174 hamster S194-p 450442 RCAKRRGsTCVLAGI START enzymatic activity, induced 15336703 9 1 0 -PTH1R PTHR GPCR, family 2; Membrane protein, integral; Membrane protein, multi-pass; Receptor, GPCR Q03431 5745 3p21.31 human T503-p 58924701 YGPMVSHtSVTNVGP receptor internalization, induced; molecular association, regulation ARR3(INDUCES) 27623777 1 1 0 S503 AND T504 IN THE SECOND CLUSTER ARE RESPONSIBLE FOR 70% OF ARRESTIN3 RECRUITMENT -Ilk ILK EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, Ser/Thr (non-receptor); Protein kinase, TKL O55222 16202 7|7 E3 mouse S343-p 448495 SMADVKFsFQCPGRM PK_Tyr_Ser-Thr enzymatic activity, induced 25098415 4 0 1 -MAP2K6 MKK6 EC 2.7.12.2; KINASE; Kinase, protein; Protein kinase, STE; Protein kinase, dual-specificity (non-receptor) P52564 5608 17q24.3 human T211-p 448195 LVDSVAKtIDAGCKP Pkinase enzymatic activity, induced; phosphorylation transcription, induced; signaling pathway regulation 11460167; 8622669 4 2 2 -PRMT5 PRMT5 Cell cycle regulation; EC 2.1.1.125; METHYLTRANSFERASE; Methyltransferase; Methyltransferase, protein arginine; RNA processing O14744 10419 14q11.2 human S15-p 1868989002 GAGGSRVsSGRDLNC molecular association, regulation; enzymatic activity, induced carcinogenesis, induced; cell motility, induced; cell growth, induced; transcription, induced NFkB-p65(INDUCES) 32456215 1 0 0 Regulation of NFkB activation and methyltransferase activity -Npr2 ANPB EC 4.6.1.2; Guanylyl cyclase; KINASE; Kinase, protein; Lyase; Membrane protein, integral; Nucleotide Metabolism - purine; Protein kinase, RGC; Protein kinase, dual-specificity (receptor); Receptor, misc. P16067 116564 5q22 rat T516-p 450026 KGAGSRLtLSLRGSS activity, induced 9624142 2 1 0 -PPP1R1B DARPP-32 Motility/polarity/chemotaxis; Protein phosphatase, regulatory subunit Q9UD71 84152 17q12 human T34-p 448047 MIRRRRPtPAMLFRL DARPP-32 carcinogenesis, induced; cell motility, altered; cytoskeletal reorganization; signaling pathway regulation 19651774; 36966223 67 6 44 induces ERK signaling -EGR1 EGR1 C2H2-type zinc finger protein; DNA-binding; Transcription factor P18146 1958 5q31.2 human T148-p 11423703 PAPNSGNtLWPEPLF DUF3446 transcription, altered DNA(DISRUPTS) 8662759 1 0 0 -CHEK2 Chk2 EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, CAMK; Protein kinase, Ser/Thr (non-receptor); Tumor suppressor O96017 11200 22q12.1 human S516-p 448840 PQVLAQPsTSRKRPR enzymatic activity, induced cell cycle regulation; apoptosis, induced; transcription, induced 12805407; 12855706; 26391395; 30573684; 36007676 16 4 0 CRp53 -CYSLTR1 CYSLTR1 GPCR, family 1; Membrane protein, integral; Membrane protein, multi-pass; Receptor, GPCR Q9Y271 10800 Xq21.1 human S316-p 11146368 FRKHSLSsVTYVPRK receptor desensitization, induced transcription, induced 22230957 1 3 0 -Slco1a1 SLCO1A1 Membrane protein, integral; Transporter P46720 50572 4q44 rat S634-p 460719 QFPGDIDsSATDHTE molecular association, regulation; intracellular localization PDZK1(INDUCES) 21183661 1 1 0 plasma membrane distribution of SLCO1A1 requires interaction of its unphosphorylated form with PDZK1 -Kcnj1 ROMK iso2 Channel, potassium; Membrane protein, integral; Membrane protein, multi-pass P35560-2 rat S294-p 2461200 ATCQVRTsYVPEEVL IRK_C activity, induced 8621594 5 0 0 phosphorylation of at least two serines necessary for channel activity -USP37 USP37 DEUBIQUITINASE; EC 3.4.19.12; Protease; Ubiquitin conjugating system; Ubiquitin-specific protease Q86T82 57695 2q35 human S628-p 469345 MVNSCITsPSTPSKK UCH protein stabilization; ubiquitination cell cycle regulation 21596315 2 3 14 induces deubiquitination -RPA2 RFA2 DNA replication P15927 6118 1p35.3 human S12-p 1854602 GFESYGSsSYGGAGG molecular association, regulation; intracellular localization DNA repair, induced; cell growth, altered WRN(INDUCES) 17035231; 21107010 3 1 0 upon replication blockage, WRN and RPA functionally interact ; 7xAlanine mutant has defect in down regulating DNA synthesis following UV treatment. 7xAspartate mutant did not localize to S-phase foci. -FOXC2 FOXC2 Apoptosis; Cell development/differentiation; DNA-binding; Transcription factor Q99958 2303 16q24.1 human S240-p 3210585 PESALQGsPRSAAST molecular association, regulation transcription, altered DNA(INDUCES) 23878394 1 23 0 implicated in vascular remodeling in vivo -MLLT1 MLLT1 Oncoprotein; Transcription regulation Q03111 4298 19p13.3 human K469-ac 1881852003 KPPPPNSkVSGRRSP cell growth, induced 35108652 1 0 0 Sirt2 deletion AML cells showed significantly increased proliferation -Lmna lamin A/C Cytoskeletal P48679 60374 2q34 rat S301-p 480106 QSRIRIDsLSAQLSQ Filament protein degradation cell differentiation, induced 26045045 3 24 137 reduced nuclear size -Wnk4 WNK4 EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, Other; Protein kinase, Ser/Thr (non-receptor) Q80UE6 69847 11|11 D mouse K183-ub 40323313 EIGRGSFkTVYRGLD Pkinase protein degradation 23576762 1 1 0 regulates electrolyte homeostasis and involved in Pseudohypoaldosteronism type II (PHAII) pathogenesis -Pdc phosducin G protein regulator, misc. P20942 25343 13q21 rat S73-p 451205 ERMSRKMsIQEYELI Phosducin protein stabilization; molecular association, regulation; protein conformation G-gamma 2(DISRUPTS); 14-3-3 zeta(INDUCES); G-beta 1(DISRUPTS) 10360181; 11331285; 23199924; 25971962; 28402877 7 3 0 slows down the dephosphorylation of pS54 and pS73 -MYC Myc DNA-binding; Nucleolus; Oncoprotein; Transcription factor P01106 4609 8q24.21 human K172-ac 458890 ASYQAARkDSGSPNP Myc_N molecular association, regulation ZBTB17(INDUCES) 16126174 3 2 0 induces association with ZBTB17 on specific target promoters -G6PC1 G6PC1 Carbohydrate Metabolism - galactose; Carbohydrate Metabolism - glycolysis and gluconeogenesis; Carbohydrate Metabolism - starch and sucrose; EC 3.1.3.9; Endoplasmic reticulum; Membrane protein, integral; Membrane protein, multi-pass; Phosphatase (non-protein); Transporter; Transporter, SLC family P35575 2538 17q21.31 human H119-p 27988900 GPGSPSGhAMGTAGV PAP2; TM enzymatic activity, induced 7744838 1 0 0 Likely that H119 is the phosphate acceptor in G6PC. -GATA6 GATA6 iso2 Motility/polarity/chemotaxis; Transcription factor Q92908-2 2627 18q11.2 human S290-p 18009944 KPQKRVPsSRRLGLS protein stabilization; molecular association, regulation cell growth, inhibited; transcription, induced DNA(INDUCES) 25969542 1 2 0 -Etv4 ETV4 DNA-binding P28322 18612 11 D|11 65.48 cM mouse K227-sm 3144819 PYPQQNFkQEYHDPL ETS_PEA3_N protein degradation; ubiquitination transcription, induced; transcription, inhibited 18447755; 19307308 4 1 0 -Camk2b CAMK2B EC 2.7.11.17; KINASE; Kinase, protein; Protein kinase, CAMK; Protein kinase, Ser/Thr (non-receptor) P28652 12323 11 A1|11 3.89 cM mouse S26-p 455245 DIGKGAFsVVRRCVK Pkinase enzymatic activity, inhibited 36194579 1 4 0 -CAV1 caveolin-1 Adaptor/scaffold; Motility/polarity/chemotaxis; Nuclear receptor co-regulator Q03135 857 7q31.2 human K57-ub 21170998 DLVNRDPkHLNDDVV Caveolin molecular association, regulation; intracellular localization UBXN6(INDUCES); VCP(INDUCES) 23335559 1 5 0 CAV1 ubiquitylation and binding to the VCP-UBXD1 complex and sorting into lysosomes -ARHGAP25 ARHGAP25 GAP; GAP, Rac/Rho P42331 9938 2p13.3 human S362-p 12738768 KSKDIPLsPPAQKND activity, inhibited endocytosis, induced 36190314 1 17 0 -Lima1 eplin Actin-binding; Cytoskeletal; Motility/polarity/chemotaxis Q9ERG0 65970 15 F1|15 56.13 cM mouse S602-p 459750 FRTSSIKsPKASSPS molecular association, regulation; intracellular localization cell motility, induced; cytoskeletal reorganization ACTB(DISRUPTS) 17875928 3 29 16 destabilization of stress fibres, membrane ruffle formation -TAB1 TAB1 Activator; Motility/polarity/chemotaxis Q15750 10454 22q13.1 human S457-p 22869800 TQSSSSSsDGGLFRS intracellular localization; phosphorylation; enzymatic activity, induced transcription, inhibited 22216226 1 0 0 TAB1 induce p38 MAPK phosphorylation and mRNA destabilization, induces p38 MAPK activation. TAB1 and p38MAPK mutually control eachother's phosphorylation status, activity and intracellular localization. -TARDBP TDP-43 RNA-binding Q13148 23435 1p36.22 human S375-p 6855909 GSGNNSYsGSNSGAA molecular association, regulation cell cycle regulation; cell growth, induced; apoptosis, inhibited; transcription, altered TDP-43(DISRUPTS) 35835219 2 0 0 -SFRP4 SFRP4 Secreted; Secreted, signal peptide Q6FHJ7 6424 7p14.1 human T186-p 50799489 KCKKVKPtLATYLSK molecular association, regulation carcinogenesis, induced; transcription, induced; signaling pathway regulation CTNNB1(INDUCES) 31390565 1 1 0 induces B-catenin transcriptional activity and CD133 expression, regulates Wnt/B-catenin signaling pathway -Eps8 EPS8 Adaptor/scaffold Q08509 13860 6 G1|6 66.78 cM mouse S624-p 7101206 ADTPSAPsPPPTPAP intracellular localization cytoskeletal reorganization 19564905 1 11 0 -Dpysl2 CRMP-2 Microtubule-binding; Motility/polarity/chemotaxis O08553 12934 14 D1|14 34.6 cM mouse T514-p 454386 SVTPKTVtPASSAKT molecular association, regulation neural plasticity; cell motility, induced; cytoskeletal reorganization; cell growth, altered DRP1(DISRUPTS); RHOT2(DISRUPTS) 20961402; 25073924; 34685760; 36293516 33 36 35 -BCR Bcr EC 2.7.11.1; GAP; GAP, Rac/Rho; GEF, Rac/Rho; KINASE; Kinase, protein; Oncoprotein; Protein kinase, Ser/Thr (non-receptor); Protein kinase, atypical P11274 613 22q11.23 human Y328-p 447795 FEDCGGGyTPDCSSN enzymatic activity, induced 9467953 2 0 0 -TPPP TPPP Cytoskeletal O94811 11076 5p15.33 human S159-p 487537 SGVTKAIsSPTVSRL p25-alpha acetylation; phosphorylation transcription, induced 23727580 2 5 1 decreases B-Catennin phosphorylation and acetylation and induces its expression -Gorasp1 GRASP65 Vesicle O35254 56082 8q32 rat T224-p 4768154 SPGTPAKtPQPNAFP intracellular localization cell cycle regulation 23259055 1 0 0 Regulation of mitotic golgi disassembly and reassembly; inactivation of T220/T224, and eventually S277partial dephosphorylation -Pld1 PLD1 EC 3.1.4.4; Lipid Metabolism - ether lipid; Lipid Metabolism - glycerophospholipid; Motility/polarity/chemotaxis; Phospholipase P70496 25096 2q24 rat T147-p 448573 PIPTKRHtFRRQNVK PX intracellular localization; enzymatic activity, induced exocytosis, altered 12429840; 18550821 5 0 0 Phosphorylation occurs in caveolin-enriched membrane fraction and is localized to the plasma membrane in cells.; T147-p is required for PLD1 mediated PA production and exocytosis. -AGAP2 CENTG1 iso2 GAP; GAP, ARF; Motility/polarity/chemotaxis; Tumor suppressor Q99490-2 116986 12q14.1 human S279-p 478561 YSSSLPSsPNVGHRE molecular association, regulation; enzymatic activity, induced cell motility, altered Akt1(DISRUPTS) 18487454 1 2 20 -WT1 WT1 iso7 C2H2-type zinc finger protein; DNA-binding; Nucleolus; Transcription factor; Tumor suppressor P19544-7 7490 11p13 human S63-p 1871128700 ERLQGRRsRGASGSE protein degradation; molecular association, regulation; ubiquitination carcinogenesis, inhibited; cell growth, inhibited; transcription, inhibited FBXW8(INDUCES) 33184107 1 1 0 -ITGB1 ITGB1 Cell adhesion; Cell surface; Membrane protein, integral; Motility/polarity/chemotaxis; Receptor, misc. P05556 3688 10p11.22 human Y795-p 447711 TTVVNPKyEGK____ Integrin_b_cyt molecular association, regulation; intracellular localization kindlin-2(DISRUPTS); tensin 1 iso1(INDUCES) 17473008; 20702409 7 13 211 -DNM1L DRP1 Apoptosis; EC 3.6.5.5; Endoplasmic reticulum; Hydrolase; Microtubule-binding; Mitochondrial; Motor O00429 10059 12p11.21 human K532-sm 9859919 PSAVSRDkSSKVPSA activity, induced; intracellular localization 19638400 1 0 0 sumoylation is linked to its GTPase activity cycle, and influenced by DRP1 localization -Dennd3 DENND3 GEF; GEF, Rab A2RT67 105841 15|15 D3 mouse Y940-p 15568930 HAASKLAyFDNMKKK molecular association, regulation; protein conformation DENND3(DISRUPTS) 28249939 1 0 1 -RUNX1 AML1 DNA-binding; Oncoprotein; Transcription factor Q01196 861 21q22.12 human K24-ac 459071 STALSPGkMSEALPL molecular association, regulation cell growth, induced; transcription, induced DNA(INDUCES) 14752096 1 4 15 transformation increased -PINK1 PINK1 EC 2.7.11.1; KINASE; Kinase, protein; Membrane protein, integral; Mitochondrial; Protein kinase, Other; Protein kinase, Ser/Thr (non-receptor) Q9BXM7 65018 1p36.12 human S228-p 25792200 MWNISAGsSSEAILN ubiquitination; intracellular localization; phosphorylation; enzymatic activity, induced 22910362; 23754282; 25527497 8 2 0 T313A and S402A mutants interfere with PINK1 phosphorylation; regulate substrate phosphorylation, Parkin and Ubiquitin; promotes mitochondrial localization of parkin; induce Ubiquitin-oxyester formation -FOXG1 FOXG1 DNA-binding; Nuclear receptor co-regulator; Transcription factor P55316 2290 14q12 human T279-p 482881 KLRRRSTtSRAKLAF intracellular localization 17435750 3 0 0 -Frs2 FRS2 Adaptor/scaffold Q8C180 327826 10|10 D2 mouse Y392-p 449785 NLDPMHNyVNTENVT molecular association, regulation GRB2(INDUCES) 9182757 3 2 26 -WWC1 KIBRA Adaptor/scaffold Q8IX03 23286 5q34 human T1006-p 54400801 RTWHSQLtQEISVLK DNA repair, induced; cell growth, induced 26929199 1 0 0 required for optimal DNA double-strand break repair in cancer cells -COX2 COX2 EC 1.9.3.1; Energy Metabolism - oxidative phosphorylation; Membrane protein, integral; Membrane protein, multi-pass; Mitochondrial; Oxidoreductase P68530 3283880 cow S126-p 25265503 DSYMIPTsELKPGEL COX2 signaling pathway regulation 21771582 0 2 0 regualtion of electron transport chain -KLHL3 KLHL3 Actin-binding; Cytoskeletal Q9UH77 26249 5q31.2 human S433-p 36440206 PMNTRRSsVGVGVVE Kelch_1 protein stabilization; molecular association, regulation; ubiquitination; protein conformation signaling pathway regulation WNK4(DISRUPTS) 25313067; 26435498; 27727489; 27942049; 30718414 6 2 0 -H3c1 H3 DNA-binding P68433 360198 13|13 A3.1 mouse K36-m3 1458608 APATGGVkKPHRYRP Histone cell differentiation, induced; chromatin organization, altered; transcription, induced; transcription, inhibited 19434510; 23428873; 26370508; 33743353 65 11 4 Setd2 knockout embryos suffer from anemia, Setd2 de?ciency impairs terminal differentiation, Increased nucleated erythrocytes; repressive effect on noncoding RNA (ncRNA) Xist promoter -EIF4ENIF1 4E-T Karyopherin; Nuclear import; Translation Q9NRA8 56478 22q12.2 human S587-p 454357 YLRPRIPsPIGFTPG EIF4E-T molecular association, regulation 4E-T(INDUCES) 22966201 1 30 113 required for processing bodies (PBs or P bodies) assembly -FERMT3 kindlin-3 Cell adhesion Q86UX7 83706 11q13.1 human T482-p 15406839 AFLSLQRtGSGGPGN FERM_M activity, induced cell motility, induced; cell adhesion, induced 25609252 1 1 0 integrin activation, adhesion and spreading -NPFFR2 NPFFR2 GPCR, family 1; Membrane protein, integral; Membrane protein, multi-pass; Receptor, GPCR Q9Y5X5 10886 4q13.3 human T516-p 36533408 VMEELKEtTNSSEI_ receptor desensitization, induced 25326382 1 1 0 -HJURP HJURP Histone-binding; Nucleolus Q8NCD3 55355 2q37.1 human S448-p 3206595 LHREYCLsPRNQPRR HJURP_C molecular association, regulation; intracellular localization cell cycle regulation OIP5(DISRUPTS) 24519934 2 9 6 Mis18 binds with HJURP and specifies the centromere localization -Lrp4 LRP4 Cell surface; Membrane protein, integral; Receptor, misc. Q9QYP1 83469 3q24 rat S1900-p 465667 WKHERKLsSESQV__ molecular association, regulation DLG1(DISRUPTS); PSD-95(DISRUPTS) 16819975 1 2 4 -PAK6 PAK6 EC 2.7.11.1; KINASE; Kinase, protein; Nuclear receptor co-regulator; Protein kinase, STE; Protein kinase, Ser/Thr (non-receptor) Q9NQU5 56924 15q15.1 human S165-p 454427 MPWPEPQsPRVLPNG enzymatic activity, induced 15550393 1 2 0 -MRE11 MRE11A Cell cycle regulation; DNA repair, damage; DNA-binding; Deoxyribonuclease P49959 4361 11q21 human S264-p 486366 EQQLFYIsQPGSSVV molecular association, regulation DNA(DISRUPTS) 19709933 2 0 0 -TOB2 TOB2 Q14106 10766 22q13.2 human S155-p 22999101 SSLSNSPsPSFGQSP cell growth, inhibited 22252318 1 0 0 promote mRNA deadenylaion and decay and the ability to suppress proliferation -PSEN1 PSEN1 Cell surface; EC 3.4.23.-; Membrane protein, integral; Membrane protein, multi-pass; Mitochondrial; Protease P49768 5663 14q24.2 human S313-p 62906105 QRRVSKNsKYNAEST Presenilin protein conformation 28132667 1 1 0 PS1 pathogenic conformational shift -Pfkfb1 PFKFB1 Carbohydrate Metabolism - fructose and mannose; EC 2.7.1.105; EC 3.1.3.46; Kinase, other; Motility/polarity/chemotaxis; Phosphatase (non-protein) P07953 24638 Xq13 rat S33-p 456206 VLQRRRGsSIPQFTN 6PF2K molecular association, regulation; intracellular localization; enzymatic activity, inhibited; enzymatic activity, induced PFKFB1(INDUCES) DNA(DISRUPTS) 10749675; 15983194; 22668829; 7619045 6 3 0 decreases the PFK activity, increases the FBPase activity -SYT6 SYT6 Membrane protein, integral; Vesicle Q5T7P8 148281 1p13.2 human T418-p 456499 RLKKKKTtIKKNTLN C2 activity, induced 16111671 1 0 0 -Ceacam1 CEACAM1 Cell adhesion; Immunoglobulin superfamily; Membrane protein, integral; Motility/polarity/chemotaxis P16573 81613 1q21 rat S449-p 22636602 ALAYFLYsRKTGGGS molecular association, regulation Calmodulin(DISRUPTS) 9541029 1 0 0 -MARS1 MARS Aminoacyl-tRNA synthetase; EC 6.1.1.10; Ligase; Other Amino Acids Metabolism - selenoamino acid; Translation; Translation regulation P56192 4141 12q13.3 human S662-p 22496701 NRAGMFVsKFFGGYV molecular association, regulation; enzymatic activity, inhibited; protein conformation translation, inhibited EEF1E1(DISRUPTS) 22106287 1 1 0 -Clip1 Restin Cytoskeletal Q9JK25 65201 12q16 rat S313-p 4769839 LKRSPSAsSLSSMSS molecular association, regulation TUBA1C(DISRUPTS) 20519438 1 3 0 -Adam17 TACE EC 3.4.24.86; Membrane protein, integral; Motility/polarity/chemotaxis; Protease Q9Z1K9 57027 6q16 rat Y702-p 28706300 DKKLDKQyESLSLFH activity, induced; phosphorylation; enzymatic activity, induced 23868980; 25371038 3 0 0 p38 is phosphorylated and activated due to TACE phosphorylation.; myogenesis activation, p38MAPK activation (phosphorylation), TNF-a release -FOXO3 FOXO3A Autophagy; DNA-binding; Oncoprotein; Transcription factor O43524 2309 6q21 human K245-ac 50771300 PDGGKSGkAPRRRAV Forkhead activity, induced; intracellular localization; phosphorylation 26376801 1 0 0 K245 and K242 acetylation is associated with JNK activation, nuclear localization, and S7 phosphorylation -PPP2CA PPP2CA EC 3.1.3.16; Motility/polarity/chemotaxis; PHOSPHATASE; Protein phosphatase, Ser/Thr (non-receptor) P67775 5515 5q31.1 human L309-me 3627520 RRTPDYFl_______ molecular association, regulation; enzymatic activity, induced; phosphorylation carcinogenesis, inhibited; cell growth, inhibited; apoptosis, induced; signaling pathway regulation 24253382; 32315619; 8206937 10 0 0 inhibits ERK and AKT phosphorylation and signaling -PHLPP1 PHLPP EC 3.1.3.16; PHOSPHATASE; Protein phosphatase, Ser/Thr (non-receptor); Tumor suppressor O60346 23239 18q21.33 human S425-p 23131538 KAPRAIDsPGGAVRE cell cycle regulation 33397691 1 9 1 -TP53 p53 Activator; DNA-binding; Motility/polarity/chemotaxis; Nuclear receptor co-regulator; Transcription factor; Tumor suppressor P04637 7157 17p13.1 human K382-m1 4061501 QSTSRHKkLMFKTEG activity, inhibited cell cycle regulation; carcinogenesis, inhibited; apoptosis, inhibited; transcription, inhibited 17707234; 27535933 2 1 0 -Ctnnd2 CTNND2 Actin-binding; Motility/polarity/chemotaxis NP_001258431 114028 2q22 rat S444-p 480954 RTSTAPSsPGVDSVP cytoskeletal reorganization 19054758 1 9 1 mutation of site to alanine increases dendrite branching -Brsk2 BRSK2 EC 2.7.11.1; EC 2.7.11.26; KINASE; Kinase, protein; Protein kinase, CAMK; Protein kinase, Ser/Thr (non-receptor) Q69Z98 75770 7|7 F5 mouse T510-p 3572413 PEEMSNLtPESSPEL protein stabilization; enzymatic activity, inhibited; phosphorylation 23790753 1 11 10 inhibits axon branching (activated in BRSK2 18A mutant) -PSMA7 PSMA7 EC 3.4.25.1; Protease; Proteasome complex O14818 5688 20q13.33 human Y153-p 456317 QTDPSGTyHAWKANA Proteasome enzymatic activity, inhibited cell cycle regulation 16678104 2 5 65 -XRCC5 Ku80 DNA-binding; EC 3.6.1.-; EC 3.6.4.-; Helicase; Nuclear receptor co-regulator; Nucleolus; RNA-binding P13010 7520 2q35 human K469-ub 12398997 SLAKKDEkTDTLEDL molecular association, regulation DNA repair, induced DNA(DISRUPTS) 27895153 1 2 4 -Grik2 GluR6 Channel, calcium; Channel, ligand-gated; Membrane protein, integral; Membrane protein, multi-pass P42260 54257 20q13 rat S846-p 11496000 VGEFLYKsKKNAQLE receptor recycling, inhibited; molecular association, regulation exocytosis, inhibited 14-3-3 theta(INDUCES) 23861400; 28636947 5 0 0 recycled more ef?ciently to the cell surface -PIK3R2 PIK3R2 Kinase, lipid; Motility/polarity/chemotaxis O00459 5296 19p13.11 human Y655-p 25749689 ESSQRGCyACSVVVD SH2 protein stabilization; molecular association, regulation carcinogenesis, inhibited; autophagy, induced; signaling pathway regulation FBXL2(DISRUPTS) 23604317; 28915558 2 0 1 -Sirt1 SIRT1 Apoptosis; DEACETYLASE; Deacetylase; EC 3.5.1.-; Nuclear receptor co-regulator Q923E4 93759 10|10 B4 mouse S154-p 6006902 NGFHSCEsDDDDRTS enzymatic activity, induced apoptosis, inhibited; transcription, induced 19680552; 27470296 2 5 0 ERb expression, reduced S154 phosphorylation in aging mouse leads to reduced ERB expression ; deacetylates p53 K382 and NFkB-p65 -RANGAP1 RANGAP1 GAP; GAP, Ras P46060 5905 22q13.2 human K524-sm 2251700 LVHMGLLkSEDKVKA RanGAP1_C sumoylation; intracellular localization; protein conformation 15355965; 34110283 11 12 0 change in resonances from residues 519 to 534 ; WT RANGAP1 rescues nuclear import of NF-ATc1, NF-kB, AP-1 in RanGAP1 (KD), required in various nuclear transport pathways -Rit1 RIT1 G protein; G protein, monomeric; G protein, monomeric, Ras P70426 19769 3|3 F1 mouse K187-ub 964541202 REIRKKEkELVLAME protein degradation; ubiquitination 30872527 1 2 0 ubiquitination occured only when TUBEs and LZTR1 were coexpressed, when RIT1 oncogenic mutations are present ubiquitination was decreased -IKZF1 Ikaros C2H2-type zinc finger protein; DNA-binding; Transcription factor Q13422 10320 7p12.2 human K429-sm 56819000 ARNGLSLkEEHRAYD carcinogenesis, induced; cell growth, induced 27315244 1 0 0 -RSAD2 RSAD2 Q8WXG1 91543 2p25.2 human K206-ub 12402572 NHVENLQkLRRWCRD Radical_SAM protein degradation 31812350 1 1 1 -PIK3C3 PIK3C3 Autophagy; Carbohydrate Metabolism - inositol phosphate; EC 2.7.1.137; Kinase, lipid; Motility/polarity/chemotaxis Q8NEB9 5289 18q12.3 human K840-sm 31077507 LEPDKTVkKVQDKFR enzymatic activity, induced autophagy, induced 23569248 2 0 0 -DYRK1A DYRK1A EC 2.7.12.2; KINASE; Kinase, protein; Protein kinase, CMGC; Protein kinase, dual-specificity (non-receptor) Q13627 1859 21q22.13 human Y147-p 463250 YDDDNYDyIVKNGEK intracellular localization cell cycle regulation; cell differentiation, altered 21878370 1 2 18 -NPHS1 NPHS1 Cell adhesion; Immunoglobulin superfamily; Membrane protein, integral O60500 4868 19q13.12 human Y1217-p 469566 YQDPRGIyDQVAGDL protein degradation; intracellular localization endocytosis, induced; exocytosis, induced; cell adhesion, induced; cytoskeletal reorganization; translation, inhibited 19882202; 22718751; 25404734 10 0 0 -Rb1 Rb Nuclear receptor co-regulator; Oncoprotein; Transcription, coactivator/corepressor; Tumor suppressor P13405 19645 14 38.73 cM|14 D3 mouse S773-p 447978 STRPPTLsPIPHIPR Rb_C molecular association, regulation; phosphorylation cell cycle regulation; cell growth, induced; DNA repair, inhibited E2F1(DISRUPTS) 10207050; 35023164 98 17 128 -Myc Myc DNA-binding; Nucleolus; Oncoprotein; Transcription factor P01108 17869 15 D1|15 26.19 cM mouse S388-p 450961 RRNELKRsFFALRDQ HLH molecular association, regulation; activity, inhibited cell cycle regulation; apoptosis, inhibited; transcription, altered; transcription, inhibited; cell growth, altered MAX(DISRUPTS) 14749374; 20043278 8 0 0 mutation of this site enhances epidermal differentiation -Nr5a1 STF-1 Nuclear receptor; Transcription, coactivator/corepressor P33242 26423 2 B|2 24.42 cM mouse S203-p 447603 EYPEPYAsPPQQPGP activity, induced; molecular association, regulation; protein conformation transcription, induced; transcription, altered SMRT(INDUCES); GRIP1(INDUCES) 10230405; 12242296; 12920232; 19015234; 24232453 11 0 0 -CRK CRK Adaptor/scaffold; Motility/polarity/chemotaxis; Oncoprotein P46108 1398 17p13.3 human Y251-p 456549 QKRVPNAyDKTALAL SH3_2 molecular association, regulation; enzymatic activity, induced cell motility, induced; cell adhesion, inhibited Arg(INDUCES); STAP1(INDUCES); Abl(INDUCES); Abi-1(INDUCES); SHIP-2(INDUCES); SHC2(INDUCES) 21602891; 25381819; 26473374 3 11 308 -ZNF746 PARIS C2H2-type zinc finger protein; Transcription regulation Q6NUN9 155061 7q36.1 human Y137-p 13831906 ETLVSLDyAISKPEV activity, induced; molecular association, regulation; acetylation; intracellular localization; phosphorylation; enzymatic activity, induced apoptosis, induced; transcription, inhibited; signaling pathway regulation TIF1B(INDUCES) 34581802 1 1 0 induces p53 phosphorylation and activation and c-Abl activation, inhibits histone acetylation, regulates MDM4-p53/PGC-1-NRF1 pathway -CLASP2 CLASP2 Cytoskeletal; Motility/polarity/chemotaxis O75122 23122 3p22.3 human S533-p 22349885 QGCSREAsRESSRDT molecular association, regulation; intracellular localization cytoskeletal reorganization EB1(DISRUPTS); IQGAP1(DISRUPTS) 19638411 1 4 0 inhibits binding with microtubules -NR4A1 Nur77 Apoptosis; DNA-binding; Nuclear receptor P22736 3164 12q13.13 human K536-ub 1869841400 NRIASCLkEHVAAVA Hormone_recep protein degradation 33087562 2 0 0 -Sik1 SIK EC 2.7.11.1; KINASE; Kinase, protein; Motility/polarity/chemotaxis; Protein kinase, CAMK; Protein kinase, Ser/Thr (non-receptor); Tumor suppressor Q9R1U5 59329 20p12 rat T322-p 990311 LGIDRQRtVESLQNS enzymatic activity, induced 17939993 1 0 0 -KCNJ13 KCNJ13 Channel, potassium; Membrane protein, integral; Membrane protein, multi-pass O60928 3769 2q37.1 human S201-p 6039502 TRPSPLTsVRVSAVL IRK_C activity, inhibited 18976636 1 0 0 -Gja1 GJA1 Channel, misc.; Membrane protein, integral; Membrane protein, multi-pass; Motility/polarity/chemotaxis P08050 24392 20q11 rat S369-p 459208 RPSSRASsRASSRPR activity, induced; intracellular localization; protein conformation 12417300; 12697837; 16709897 15 8 2 BIM treatment in Rin43 cells and NRK-CT cells reduced multiple open states. In ischemic hearts Cx43 was uniformly distributed around each myocyte. ; altered intracellular localization during cell cycle; gap junction/intercellular communication -SHC1 SHC1 Adaptor/scaffold; Apoptosis; Mitochondrial; Motility/polarity/chemotaxis P29353 6464 1q21.3 human S139-p 448791 EEWTRHGsFVNKPTR apoptosis, induced 27624939 4 35 16 -AURKA AurA EC 2.7.11.1; KINASE; Kinase, protein; Oncoprotein; Protein kinase, Other; Protein kinase, Ser/Thr (non-receptor) A5GFW1 574063 pig S283-p 3339003 GWSVHAPsSRRTTLC Pkinase cell cycle regulation 18614302 1 0 0 -PRKCD PKCD EC 2.7.11.13; KINASE; Kinase, protein; Nuclear receptor co-regulator; Protein kinase, AGC; Protein kinase, Ser/Thr (non-receptor); Protein kinase, tyrosine (non-receptor); Tumor suppressor Q05655 5580 3p21.1 human Y64-p 447581 STFDAHIyEGRVIQI activity, inhibited; phosphorylation apoptosis, altered; apoptosis, induced 11927579; 18434324 7 3 31 ERK phosphorylation/activation -Ppp1r2 PPP1R2 Inhibitor; Motility/polarity/chemotaxis; Protein phosphatase, regulatory subunit P50411 192361 11q22 rat S44-p 2231000 EEELSKKsQKWDEMN enzymatic activity, induced neural plasticity 23825423 2 0 0 -Rbl2 Rb-like 2 Transcription, coactivator/corepressor; Tumor suppressor Q64700 19651 8 C4|8 44.25 cM mouse K130-ac 15207811 IEFFNKMkKWEDMAN DUF3452 phosphorylation 23029429 2 1 0 enhances phosphorylation of Rb-like2 -Th TH Amino Acid Metabolism - tyrosine; EC 1.14.16.2; Endoplasmic reticulum; Mitochondrial; Oxidoreductase; Vesicle P04177 25085 1q41 rat S40-p 448545 RFIGRRQsLIEDARK TOH_N protein stabilization; molecular association, regulation; protein conformation; enzymatic activity, induced 10820208; 11502746; 12124439; 12692140; 1347949; 15228599; 15639226; 17507557; 21302933; 33078695; 9751201 62 11 11 -Ptpn1 PTP1B EC 3.1.3.48; Motility/polarity/chemotaxis; PHOSPHATASE; Phosphatase; Protein phosphatase, tyrosine (non-receptor) P35821 19246 2|2 H3 mouse S205-p 36133122 VRESGSLsLEHGPIV Y_phosphatase phosphorylation; enzymatic activity, induced carcinogenesis, induced; apoptosis, inhibited 37000627 1 2 0 dephosphorylates CD3Z -MVB12A FAM125A Adaptor/scaffold Q96EY5 93343 19p13.11 human S207-p 13211303 NDSIYEAsSLYGISA DUF2464 protein processing 18005716 1 2 10 inhibition of HIV-1 release and infectivity -BRSK1 BRSK1 EC 2.7.11.1; EC 2.7.11.26; KINASE; Kinase, protein; Protein kinase, CAMK; Protein kinase, Ser/Thr (non-receptor) Q8TDC3 84446 19q13.42 human T189-p 456027 VGDSLLEtSCGSPHY Pkinase cytoskeletal reorganization 34936879 8 1 0 -Gsc GSC DNA-binding; Transcription factor Q02591 14836 12 E|12 54.32 cM mouse K196-sm 2887201 TREQLARkVHLREEK Homeodomain transcription, inhibited 18336814 1 0 0 SUMO modification inhibition is promoter specific -GCSAM GCET2 Unknown function Q8N6F7 257144 3q13.2 human Y86-p 449473 TYSEELCyTLINHRV HGAL activity, induced signaling pathway regulation 31362927 1 1 85 regulates B cell receptor signaling -LGALS3 galectin-3 Cell surface; Extracellular matrix; Motility/polarity/chemotaxis P17931 3958 14q22.3 human Y118-p 13213700 AGPLIVPyNLPLPGG Gal-bind_lectin protein stabilization; protein conformation carcinogenesis, induced; apoptosis, altered 20150913; 24269589 3 1 0 -Dhx33 DHX33 EC 3.6.4.13; Helicase; Nucleolus Q80VY9 216877 11|11 B4 mouse K94-ub 21172930 IGETGSGkTTQIPQY DEAD protein degradation 36403931 1 2 0 -PARL PSARL Apoptosis; EC 3.4.21.105; Membrane protein, integral; Membrane protein, multi-pass; Mitochondrial; Protease Q9H300 55486 3q27.1 human S70-p 471332 RRSDPGTsGEAYKRS protein processing 17116872 1 1 0 involved in mitochondrial fragmentation -Irf2 IRF2 DNA-binding; Transcription factor P23906 16363 8|8 B1.1 mouse Y109-p 478391 GNNAFRVyRMLPLSE IRF molecular association, regulation transcription, induced IRF8(INDUCES); PU.1(INDUCES); IRF2(INDUCES) 17200120 1 0 0 -VHL VHL Tumor suppressor; UBIQUITIN LIGASE; Ubiquitin ligase P40337 7428 3p25.3 human S43-p 15573202 EESGPEEsGPEELGA protein degradation transcription, altered 20637892; 26973240 2 0 0 VHL clevaage and subsequent degradation; regulates p53 activity and degradation of HIF1A -Rara RARA DNA-binding; Nuclear receptor; Oncoprotein; Transcription factor P11416 19401 11 D|11 62.76 cM mouse S369-p 451381 YVRKRRPsRPHMFPK Hormone_recep activity, induced; protein degradation 19029980; 7476969 8 0 0 Mutation of S369 to alanine slightly decreased both DNA binding and the ability of PKA to enhance RA-induced transcriptional activation through RAR-alpha. -NEUROG3 neurogenin 3 Cell development/differentiation; DNA-binding; Transcription factor Q9Y4Z2 50674 10q22.1 human S174-p 64303300 GDWGSLYsPVSQAGS transcription, inhibited 28441528 1 0 0 -MAP4 MAP4 Cytoskeletal; Motility/polarity/chemotaxis P27816 4134 3p21.31 human T927-p 10422252 LSRLATNtSAPDLKN Tubulin-binding protein degradation; molecular association, regulation cell cycle regulation; cytoskeletal reorganization; signaling pathway regulation E7(DISRUPTS) 31253867 1 3 8 -Pdzd11 PDZD11 Adaptor/scaffold Q9CZG9 72621 X|X C3 mouse Y7-p 462550 _MDNRIPyDDYPVVF molecular association, regulation SERCA2(INDUCES); DECR1(INDUCES); S100A4(INDUCES); MYH3(INDUCES); MRLC2(INDUCES) 18268350 0 4 40 -MYOD1 MyoD DNA-binding; RNA splicing; Transcription factor P15172 4654 11p15.1 human K102-ac 458969 LWACKACkRKTTNAD Basic molecular association, regulation; protein conformation cell differentiation, induced; transcription, induced p300(INDUCES) DNA(INDUCES) 10619020; 18222173 3 1 1 -Grik2 GluR6 Channel, calcium; Channel, ligand-gated; Membrane protein, integral; Membrane protein, multi-pass P42260 54257 20q13 rat S715-p 451343 FMSSRRQsVLVKSNE Lig_chan activity, induced 8094892 1 0 0 PKA-mediated phosphorylation increases the potentiation of the glutamate response. -CDC34 CDC34 EC 6.3.2.19; Ligase; UBIQUITIN LIGASE; Ubiquitin conjugating system; Ubiquitin ligase P49427 997 19p13.3 human S231-p 448654 FGDDEDDsGTEES__ intracellular localization 11546811 2 0 0 -Foxp3 FOXP3 C2H2-type zinc finger protein; Cell cycle regulation; DNA-binding; Transcription factor Q99JB6 20371 X A1.1|X 3.41 cM mouse K262-ac 25614400 MQAHLAGkMALAKAP protein stabilization; ubiquitination; intracellular localization cell differentiation, induced; transcription, altered 22312127; 30886050 3 1 0 inhibits ubiquitination; suppress production of the proinflammatory cytokines IFN-c and IL-17 by T cells, Treg gene expression and function -CYTH1 cytohesin 1 GEF; GEF, ARF; Motility/polarity/chemotaxis Q15438 9267 17q25.3 human S394-p 1319401 ARKKKVSsTKRH___ activity, induced 18042453 1 0 0 increase in exchange activity, GRP1 autoinhibition reversed -TWIST1 TWIST1 Cell development/differentiation; DNA-binding; Inhibitor; Transcription regulation Q15672 7291 7p21.1 human S18-p 18899301 SPADDSLsNSEEEPD protein stabilization carcinogenesis, altered; cell motility, altered 21559372 1 0 0 -LPAR1 LPAR1 GPCR, family 1; Membrane protein, integral; Membrane protein, multi-pass; Receptor, GPCR Q92633 1902 9q31.3 human T236-p 2764301 FGYVRQRtMRMSRHS 7tm_1 activity, inhibited 18501205 1 0 0 -EGFR EGFR EC 2.7.10.1; KINASE; Kinase, protein; Membrane protein, integral; Oncoprotein; Protein kinase, TK; Protein kinase, tyrosine (receptor) P00533 1956 7p11.2 human K913-ub 1065317 ELMTFGSkPYDGIPA PK_Tyr_Ser-Thr protein degradation 17940017 1 1 0 -GGA1 GGA1 Adaptor/scaffold; Vesicle Q9UJY5 26088 22q13.1 human S268-p 1245522 PTLFRLAsDTEDNDE GAT intracellular localization 14690499 1 5 38 -WDR62 WDR62 Adaptor/scaffold O43379 284403 19q13.12 human S897-p 291887111 KPESLENsILDSLEP cell cycle regulation; cytoskeletal reorganization 28973348 1 0 0 assembles astral microtubules to control spindle orientation -TTK TTK Cancer Testis Antigen (CTA); EC 2.7.12.1; KINASE; Kinase, protein; Protein kinase, Other; Protein kinase, dual-specificity (non-receptor) P33981 7272 6q14.1 human T564-p 4145511 LEEADNQtLDSYRNE Pkinase intracellular localization; enzymatic activity, induced 26119734 2 0 0 regulates spindle assembly checkpoint and recruitment of SAC proteins -Cyba CYBA EC 1.-.-.-; Membrane protein, integral; Oxidoreductase Q61462 13057 8|8 E1 mouse T147-p 7103047 ERPQVGGtIKQPPTN Cytochrom_B558a molecular association, regulation NOX4(INDUCES) 35051590 3 13 5 -BRMS1 BRMS1 Tumor suppressor Q9HCU9 25855 11q13.2 human S237-p 18007342 KKARAAVsPQKRKSD molecular association, regulation carcinogenesis, inhibited; cell motility, inhibited; transcription, inhibited SDS3(INDUCES); HDAC1(INDUCES); SIN3A(INDUCES) 34788285 1 10 1 -PDCD1 PD-1 Apoptosis; Membrane protein, integral Q15116 5133 2q37.3 human K210-ub 1877141201 RRTGQPLkEDPSAVP protein degradation 33109719 1 0 0 -BCL3 Bcl-3 Apoptosis; Nuclear receptor co-regulator; Oncoprotein; Transcription regulation P20749 602 19q13.32 human K21-ub 3627524 VDLRTRPkAAGLPGA protein degradation transcription, altered 15469820 1 1 0 -KCNQ1 Kv7.1 Channel, potassium; Membrane protein, integral; Membrane protein, multi-pass P51787 3784 11p15.5-p15.4 human T470-p 2999202 SSVRKSPtLLEVSMP activity, induced 12835205 1 1 0 -Ceacam1 CEACAM1 Cell adhesion; Immunoglobulin superfamily; Membrane protein, integral; Motility/polarity/chemotaxis P31809 26365 7 A3|7 13.84 cM mouse Y488-p 447777 NKVDDVAyTVLNFNS molecular association, regulation; intracellular localization cell growth, altered SHC1(INDUCES); SHP-2(INDUCES) 11694516; 14970258; 9867848 10 2 0 -PRMT5 PRMT5 Cell cycle regulation; EC 2.1.1.125; METHYLTRANSFERASE; Methyltransferase; Methyltransferase, protein arginine; RNA processing O14744 10419 14q11.2 human Y297-p 18545702 NRPPPNAyELFAKGY PRMT5 molecular association, regulation; enzymatic activity, inhibited carcinogenesis, altered; cell growth, altered PRMT5(DISRUPTS) 21316606 1 0 0 contributes to the mutant Jak2 V617F -induced myeloproliferative phenotype; negatively regulates hematopoietic stem/progenitor cell expansion and erythroid differentiation -NF1 NF1 iso2 GAP; GAP, Ras; Motility/polarity/chemotaxis; Nucleolus; Tumor suppressor P21359-2 4763 17q11.2 human S2578-p 456016 HLRKVSVsESNVLLD molecular association, regulation; activity, inhibited 14-3-3 beta(INDUCES) 14741381 1 1 2 -UBA52-RPS27A-UBB-UBC ubiquitin Ubiquitin-like modifier P62991 mouse S65-p 9765472 DYNIQKEsTLHLVLR ubiquitin molecular association, regulation; intracellular localization; enzymatic activity, induced autophagy, induced PARK2(INDUCES) 25474007; 33931895; 34030589 27 17 0 mitochondrial translocation and anchoring, mitophagy induced, mitochodrial degeneration ; Mitophagy induced; regulates mitochondrial homeostasis and pluripotency -RPS6KB1 p70S6K EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, AGC; Protein kinase, Ser/Thr (non-receptor); Translation P23443 6198 17q23.1 human T444-p 448358 RFIGSPRtPVSPVKF activity, induced; molecular association, regulation; enzymatic activity, induced cell cycle regulation; carcinogenesis, induced; cell growth, induced; cell adhesion, altered; signaling pathway regulation Tau iso8(NOT_REPORTED) 12759354; 15028555; 15051500; 15304500; 16364302; 21893193; 35077510; 7545671 106 37 109 PI3K/mTOR/p70S6K pathway -DNM1L DRP1 Apoptosis; EC 3.6.5.5; Endoplasmic reticulum; Hydrolase; Microtubule-binding; Mitochondrial; Motor O00429 10059 12p11.21 human Y449-p 297110001 IIQHCSNySTQELLR Dynamin_M activity, induced 29022905 1 0 0 oxidative stress-induced cell death in primary cortical neuron; increased GTPase activity -HSPA9 HSPA9B Chaperone; Heat shock protein; Nucleolus P38646 3313 5q31.2 human S65-p 483968 IDLGTTNsCVAVMEG HSP70 protein stabilization 17573779 1 0 0 ; phosphorylation of this site stabilizes HSPA9B, activates TTK and promotes centrosome re-duplication -Gap43 GAP43 Cell surface P06837 14432 16 B4|16 28.37 cM mouse S96-p 449105 TDAAPATsPKAEEPS Neuromodulin intracellular localization cell growth, induced; cytoskeletal reorganization 30240740 4 12 4 induces axon regeneration -CEP250 CEP250 Cell cycle regulation Q9BV73 11190 20q11.22 human S2392-p 4728455 AGLHHSLsHSLLAVA cell cycle regulation 20708153 1 2 0 -KDM1A LSD1 DEMETHYLASE; Demethylase; EC 1.-.-.-; Nuclear receptor co-regulator; Oxidoreductase; Transcription factor O60341 23028 1p36.12 human R838-m2 1879738504 GAMYTLPrQATPGVP protein stabilization; molecular association, regulation cell motility, induced USP7(INDUCES) 31833203 1 1 0 USP1 deubiquitinates and stabilizes LSD1, cell migration and invasion, CARM1 and USP7 regulate E-cadherin and vimentin expression -RAB7A Rab7 G protein; G protein, monomeric; G protein, monomeric, Rab P51149 7879 3q21.3 human Y183-p 449657 QETEVELyNEFPEPI molecular association, regulation; intracellular localization; phosphorylation cell motility, induced CCZ1(DISRUPTS); Vimentin(INDUCES) 26869029; 34066419 2 24 237 induces phosphorylation of AKT and PAK1, regulates NF-kB localization; Dephosphorylated Rab7 shows endosomal membrane localization. -MAP3K4 MEKK4 EC 2.7.11.25; KINASE; Kinase, protein; Protein kinase, STE; Protein kinase, Ser/Thr (non-receptor) Q9Y6R4 4216 6q26 human T1494-p 479428 KLKNNAQtMPGEVNS Pkinase enzymatic activity, induced 17242196 2 2 1 -CSF1R CSFR EC 2.7.10.1; KINASE; Kinase, protein; Membrane protein, integral; Oncoprotein; Protein kinase, TK; Protein kinase, tyrosine (receptor) P07333 1436 5q32 human Y561-p 450118 ESYEGNSyTFIDPTQ activity, induced; molecular association, regulation 11513742; 15297464; 7730365 10 1 6 -PLSCR1 PLSCR1 Calcium-binding; Membrane protein, integral O15162 5359 3q24 human Y74-p 464050 PVYNQPVyNQPVGAA molecular association, regulation; intracellular localization carcinogenesis, induced; cell growth, induced; transcription, induced SHC1(INDUCES); STAT3(INDUCES) DNA(INDUCES) 12871937; 32292520 3 0 1 induces binding to STAT1 promoter and STAT1 expression -Aurkc AurC EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, Other; Protein kinase, Ser/Thr (non-receptor) O88445 20871 7 A1|7 4.06 cM mouse T175-p 469107 RRKTMCGtLDYLPPE Pkinase enzymatic activity, inhibited 11879579 3 6 15 complex effects on enzymatic activity: mutation of T171 or T175 to alanine increases kinase activity, while double mutant is inactive. -Map2k1 MEK1 EC 2.7.12.2; KINASE; Kinase, protein; Protein kinase, STE; Protein kinase, dual-specificity (non-receptor) P31938 26395 9 C|9 34.55 cM mouse S298-p 448284 RTPGRPLsSYGMDSR Pkinase molecular association, regulation cell adhesion, altered; cell growth, altered ERK2(INDUCES) 12167697 25 4 1 -BPGM BPGM Carbohydrate Metabolism - glycolysis and gluconeogenesis; EC 3.1.3.13; EC 5.4.2.11; EC 5.4.2.4; Isomerase; Phosphatase (non-protein) P07738 669 7q33 human H11-p 27939400 YKLIMLRhGEGAWNK His_Phos_1 protein conformation 17052986 1 0 0 The enzyme conformation continuously changed during phosphoryl transfer process. -CHRM2 mAChR M2 GPCR, family 1; Membrane protein, integral; Membrane protein, multi-pass; Receptor, GPCR P08172 1129 7q33 human S286-p 459101 EKESSNDsTSVSAVA 7tm_1 receptor internalization, altered 9162044 3 0 0 Mutation of S286 T287 S288 S290 to A caused a faster rate and a greater extent of receptor internalization after agonist stimulation (transients only, not observed in stables). Mutation of all 8 sites prevented internalization (in both transients and stables). -Gucy1a1 GUCY1A1 EC 4.6.1.2; Guanylyl cyclase; Lyase; Nucleotide Metabolism - purine; Receptor, misc. P19686 497757 2q34 rat S64-p 3647001 SHPQRKTsRNRVYLH enzymatic activity, inhibited; phosphorylation 18635821 1 0 0 downregulates phosphorylation of VASP S239 -KRAS KRas G protein; G protein, monomeric; G protein, monomeric, Ras; Motility/polarity/chemotaxis; Oncoprotein P01116 3845 12p12.1 human Y64-p 5840743 DTAGQEEySAMRDQY Ras molecular association, regulation; protein conformation; activity, inhibited; phosphorylation cell growth, induced; signaling pathway regulation AGO2(INDUCES); BRAF(DISRUPTS) 26854235; 30644389; 34725361 3 5 3 regulates MAPK signaling -KCNH2 Kv11.1 Channel, potassium; Membrane protein, integral; Membrane protein, multi-pass; Motility/polarity/chemotaxis Q12809 3757 7q36.1 human S284-p 4696786 ASVRRASsADDIEAM activity, inhibited 29949809 1 9 0 reduces Kv11.1 mediated currents -MAD1L1 MAD1L1 Cell cycle regulation; Cytoskeletal Q9Y6D9 8379 7p22.3 human S546-p 1868914507 RTKVLHMsLNPTSVA MAD molecular association, regulation; intracellular localization cell cycle regulation; carcinogenesis, induced; chromatin organization, altered; cell growth, induced ZWILCH(INDUCES); ZW10(INDUCES); ROD1(INDUCES) 31291454 1 0 0 RZZ (Rod1-ZW10-ZWILCH) complex -BRAF BRAF EC 2.7.11.1; KINASE; Kinase, protein; Oncoprotein; Protein kinase, Ser/Thr (non-receptor); Protein kinase, TKL P15056 673 7q34 human S446-p 447804 KTLGRRDsSDDWEIP molecular association, regulation; protein conformation; enzymatic activity, induced carcinogenesis, induced; cell growth, induced HRas(INDUCES); BRAF(NOT_REPORTED) 15710605; 16803888; 19050761; 35173310 15 44 87 -Cish CISH O70512 83681 8q32 rat K120-ub 37044803 YLFTLSVkTTRGPTN SH2 protein degradation 25448846 1 0 0 -Irs2 IRS2 Adaptor/scaffold; Motility/polarity/chemotaxis P81122 384783 8 A1.1|8 5.35 cM mouse S1138-p 453435 GGRRRHSsETFSSTT protein stabilization; molecular association, regulation transcription, induced 14-3-3 gamma(INDUCES) 23615913 4 10 61 -NOS3 eNOS Amino Acid Metabolism - arginine and proline; EC 1.14.13.39; Oxidoreductase P29473 287024 cow S1179-p 447884 TSRIRTQsFSLQERH activity, induced; acetylation; molecular association, regulation; protein conformation; phosphorylation; enzymatic activity, induced apoptosis, inhibited; cell motility, altered Calmodulin(INDUCES); HSP90A(INDUCES) 10376602; 10514497; 10692402; 11278407; 11292821; 11988492; 12501214; 12591925; 12952971; 15319357; 16257964; 19251696; 20479254; 26560496; 26987903; 27613870; 33592314; 34474112 217 18 7 -TUBG1 TUBG1 Cytoskeletal; Motility/polarity/chemotaxis P23258 7283 17q21.2 human K344-ub 486350 LQRIRERkLANFIPW Tubulin_C intracellular localization cell cycle regulation; cytoskeletal reorganization 16166645 2 2 7 -PRKCZ PKCZ EC 2.7.11.13; KINASE; Kinase, protein; Protein kinase, AGC; Protein kinase, Ser/Thr (non-receptor) Q05513 5590 1p36.33 human Y417-p 14305100 TFCGTPNyIAPEILR Pkinase enzymatic activity, induced 20407013 1 0 0 -GNMT GNMT Amino Acid Metabolism - glycine, serine and threonine; EC 2.1.1.20; METHYLTRANSFERASE; Methyltransferase Q14749 27232 6p21.1 human S10-p 460706 DSVYRTRsLGVAAEG intracellular localization 30987732 2 7 0 -MITF MITF iso9 DNA-binding; Oncoprotein; Transcription factor O75030-9 4286 3p13 human S397-p 11126131 DPLLSSVsPGASKTS DUF3371 protein degradation 25605940 1 5 6 -PIK3R2 PIK3R2 Kinase, lipid; Motility/polarity/chemotaxis O00459 5296 19p13.11 human Y467-p 450387 YDQLYEEyTRTSQEL PI3K_P85_iSH2 carcinogenesis, induced; apoptosis, inhibited 35154579 1 13 165 -LIPE HSL EC 3.1.1.79; Lipase Q05469 3991 19q13.2 human S855-p 448804 EPMRRSVsEAALAQP molecular association, regulation; enzymatic activity, induced FABP4(INDUCES) 17785468; 19018281 27 28 1 -NFATC1 NFAT2 DNA-binding; Transcription factor O95644 4772 18q23 human S172-p 465577 YRDPSCLsPASSLSS intracellular localization transcription, inhibited 10652349; 24863062 2 0 0 -Ackr3 CMKOR1 GPCR, family 1; Membrane protein, integral; Membrane protein, multi-pass; Receptor, GPCR P56485 12778 1 D|1 45.28 cM mouse T352-p 4709314 DASRVSEtEYSALEQ protein degradation endocytosis, induced 30726732 2 3 0 promotes endocytosis and scavenging of CXCL12 and induced degradation of CXCR4 -Slc12a2 NKCC1 Membrane protein, integral; Membrane protein, multi-pass; Transporter; Transporter, SLC family P55012 20496 18 D3|18 32.15 cM mouse T205-p 455545 TNTYYLRtFGHNTMD AA_permease_N activity, induced; enzymatic activity, induced 17595523; 20463172; 26069258 20 15 13 Enzymatic activation by SLK3 requires two threonines separated by 4 amino acids. ; Ischemic cell death -KNL1 CASC5 Cancer Testis Antigen (CTA); Cell cycle regulation Q8NG31 57082 15q15.1 human T943-p 37046600 RQDDMEItRSHTTAL MELT phosphorylation 25402682 2 0 0 A mutants increased BUB1B S670 -Hdac2 HDAC2 DEACETYLASE; Deacetylase; EC 3.5.1.98; Nuclear receptor co-regulator; Transcription, coactivator/corepressor P70288 15182 10 19.44 cM|10 B1 mouse S394-p 449930 EDAVHEDsGDEDGED enzymatic activity, induced 21576649 6 87 52 -PRKN PARK2 EC 6.3.2.-; EC 6.3.2.19; Ligase; Translation; Translation regulation; UBIQUITIN LIGASE; Ubiquitin conjugating system; Ubiquitin ligase O60260 5071 6q26 human Y143-p 15624700 SPAGRSIyNSFYVYC ubiquitination; enzymatic activity, inhibited 20823226 1 1 0 inhibits PARK2 autoubiquitination -NFKB2 NFkB-p100 DNA-binding; Oncoprotein; Transcription factor Q00653 4791 10q24.32 human K863-sm 3055610 LPSTAEVkEDSAYGS protein processing; phosphorylation signaling pathway regulation 18617892 1 0 0 activation of alternative NF-kB pathway -EEF2K EEF2K EC 2.7.11.20; KINASE; Kinase, protein; Protein kinase, Ser/Thr (non-receptor); Protein kinase, atypical; Translation O00418 29904 16p12.2 human S70-p 7320074 LTKSERYsSSGSPAN enzymatic activity, inhibited carcinogenesis, induced; cell growth, induced; translation, induced 35513296 1 4 0 -Ptpra PTPRA EC 3.1.3.48; Membrane protein, integral; Motility/polarity/chemotaxis; PHOSPHATASE; Receptor protein phosphatase, tyrosine P18052 19262 2 F1|2 63.23 cM mouse S180-p 447611 QAGSHSNsFRLSNGR enzymatic activity, induced cytoskeletal reorganization 18809727 6 17 0 neurite outgrowth -DLGAP1 SAPAP1 Cytoskeletal O14490 9229 18p11.31 human S406-p 456941 KLQIRSHsYLRAVSE molecular association, regulation PSD-95(INDUCES) 22117215 2 1 1 Fluorescence Polarization -MAX MAX DNA-binding; Transcription factor P61244 4149 14q23.3 human S2-p 449307 ______MsDNDDIEV molecular association, regulation; activity, inhibited transcription, altered DNA(DISRUPTS) 37642402; 8018564 5 35 0 phosphorylation-deficient mutant inhibits transcription more efficiently -FADD FADD Adaptor/scaffold; Apoptosis Q13158 8772 11q13.3 human S200-p 40510683 MSPMSWNsDASTSEA intracellular localization 26253696 1 2 0 S200 is important for nuclear retention of FADD -Stap2 STAP2 Adaptor/scaffold Q8R0L1 106766 17|17 D mouse Y250-p 478353 PFLLDEDyEKVLGFV activity, induced 17368569 4 3 29 involved in the activation of STAT3 -STK38L NDR2 EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, AGC; Protein kinase, Ser/Thr (non-receptor) Q9Y2H1 23012 12p11.23 human T442-p 451133 DWVFLNYtYKRFEGL Pkinase_C molecular association, regulation; phosphorylation; enzymatic activity, induced cell growth, altered MST1(INDUCES); MOB1A(INDUCES); CCND1(INDUCES) 15037617; 16314523; 16488889; 23897809 4 2 8 -Grin2b NMDAR2B Channel, calcium; Channel, ligand-gated; Membrane protein, integral; Membrane protein, multi-pass Q00960 24410 4q43 rat S1480-p 454415 EKLSSIEsDV_____ NMDAR2_C molecular association, regulation; receptor internalization, altered cell growth, induced; apoptosis, inhibited DLG3(DISRUPTS); PSD-95(DISRUPTS) 15537897; 35928572 4 1 0 -HIF1A HIF1A Autophagy; DNA-binding; Transcription factor Q16665 3091 14q23.2 human K709-ac 28108000 PEEELNPkILALQNA activity, induced; molecular association, regulation; protein stabilization; ubiquitination carcinogenesis, induced; cell growth, induced; transcription, induced EGLN1(DISRUPTS) 22908229; 24681946 2 2 0 inhibits ubiquitination; regulates expression of hypoxic response target genes, inhibits HIF1A hydroxylation -CD247 CD3Z Membrane protein, integral; Receptor, misc. P20963 919 1q24.2 human Y153-p 455204 STATKDTyDALHMQA ITAM molecular association, regulation PI4K2A(INDUCES) 16337488 3 10 258 -Grik2 GluR6 Channel, calcium; Channel, ligand-gated; Membrane protein, integral; Membrane protein, multi-pass P42260 54257 20q13 rat K886-sm 12004405 PQAPVIVkTEEVINM neural plasticity; endocytosis, induced 17486098 4 0 0 -Foxo3 FOXO3A Autophagy; DNA-binding; Oncoprotein; Transcription factor Q9WVH4 56484 10 B2|10 22.79 cM mouse S252-p 449108 APRRRAVsMDNSNKY protein degradation; intracellular localization carcinogenesis, induced; cell growth, induced; apoptosis, inhibited; transcription, inhibited; translation, inhibited 21804606; 33795838; 34556581 37 19 76 -ADRA1D ADRA1D GPCR, family 1; Membrane protein, integral; Membrane protein, multi-pass; Receptor, GPCR P25100 146 20p13 human S516-p 1346843003 QLRAKVSsLSHKIRA receptor internalization, induced; molecular association, regulation; intracellular localization; receptor internalization, altered signaling pathway regulation ARRB1(INDUCES) 29551601; 30419287 2 1 0 triggers the calcium signaling pathway; regulates ERK signaling pathway, induces calcium signaling de-sensitization -LIMA1 eplin Actin-binding; Cytoskeletal; Motility/polarity/chemotaxis Q9UHB6 51474 12q13.12 human S362-p 455424 PVHPKPLsPDSRASS protein degradation; ubiquitination carcinogenesis, induced; cell adhesion, induced; cytoskeletal reorganization; cell motility, inhibited 23188829; 28465438 3 69 83 E-cadherin down regulation, EMT; formation of large plasma membrane ruffles that are characterized by highly dynamic actin rearrangements in their lamellipodia -RAD9A RAD9A Apoptosis; Cell cycle regulation; DNA replication; Deoxyribonuclease; EC 3.1.11.2 Q99638 5883 11q13.2 human Y28-p 447825 SRIGDELyLEPLEDG Rad9 molecular association, regulation apoptosis, induced Bcl-xL(INDUCES) 11971963 1 0 0 -BRCA1 BRCA1 EC 6.3.2.-; Nuclear receptor co-regulator; Transcription, coactivator/corepressor; Tumor suppressor; UBIQUITIN LIGASE; Ubiquitin conjugating system; Ubiquitin ligase P38398 672 17q21.31 human S1191-p 10272402 GELSRSPsPFTHTHL protein stabilization; molecular association, regulation; intracellular localization cell growth, induced; DNA repair, inhibited PIN1(INDUCES) 19683496; 21706030; 32193285 4 13 3 -Mknk1 Mnk1 EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, CAMK; Protein kinase, Ser/Thr (non-receptor); Translation O08605 17346 4|4 D1 mouse S396-p 11507614 GLCSMKLsPPSKSRL molecular association, regulation ERK1(INDUCES) 16162500 1 3 0 -LMNA lamin A/C Cytoskeletal P02545 4000 1q22 human S525-p 465453 NTWGCGNsLRTALIN LTD cytoskeletal reorganization 7925482 2 2 0 affects perinuclear assembly, dissasembly of lamin -PTTG1IP PTTG1IP Membrane protein, integral P53801 754 21q22.3 human Y174-p 454097 LFKEENPyARFENN_ molecular association, regulation; intracellular localization SLC5A5(INDUCES) 23678037 1 39 1992 -Cav1 caveolin-1 Adaptor/scaffold; Motility/polarity/chemotaxis; Nuclear receptor co-regulator P41350 25404 4q21 rat Y14-p 448422 VDSEGHLyTVPIREQ activity, induced; molecular association, regulation; intracellular localization endocytosis, altered RHOA(INDUCES) 10585286; 17121865; 19543529 55 45 830 activates fibronectin secretion; insulin receptor was endocytosed with Y14 phosphorylated caveolin-1 -SNAI1 Snail1 C2H2-type zinc finger protein; Transcription factor O95863 6615 20q13.13 human K187-ac 63359900 CVCGTCGkAFSRPWL zf-C2H2 protein degradation; molecular association, regulation; ubiquitination carcinogenesis, induced; transcription, induced BTRC(INDUCES); FBXL14(INDUCES); BRD4(INDUCES) 28296173; 31311807 2 0 0 BRD4 interacts with acetylated Snail to suppress its ubiquitination and degradation by competing with FBXL14 and BRD8 for binding to Snail1 ; regulates epithelial to mesenchymal transition (EMT) in lung cancer cells -TARDBP TDP-43 RNA-binding Q13148 23435 1p36.22 human K192-ac 38520207 DEPLRSRkVFVGRCT molecular association, regulation; phosphorylation transcription, inhibited RNA(DISRUPTS) 25556531; 32409664 2 1 0 enhances TDP-43 phosphorylation, enhances accumulation of TDP-43 aggregates; TDP-43-induced cell toxicity -STXBP1 STXBP1 Vesicle P61764 6812 9q34.11 human Y145-p 456431 LPYESQVySLDSADS Sec1 molecular association, regulation STX1A(INDUCES) 23962429 1 1 0 -NR4A1 Nur77 Apoptosis; DNA-binding; Nuclear receptor P22736 3164 12q13.13 human S431-p 21697917 IPGFAELsPADQDLL Hormone_recep molecular association, regulation cell cycle regulation; transcription, induced PIN1(INDUCES) 22002310 1 0 0 -PKM PKM Carbohydrate Metabolism - glycolysis and gluconeogenesis; Carbohydrate Metabolism - pyruvate; EC 2.7.1.40; KINASE; Kinase, other; Mitochondrial; Nucleotide Metabolism - purine P14618 5315 15q23 human S100-p 4708572 TATESFAsDPILYRP PK intracellular localization 34244606 1 13 25 -DDX41 DDX41 EC 3.6.4.13; Helicase; RNA splicing; RNA-binding; Spliceosome Q9UJV9 51428 5q35.3 human Y414-p 40253300 DVIQEVEyVKEEAKM molecular association, regulation STING(INDUCES) DNA(INDUCES) 25704810 2 2 0 -MTHFD2 MTHFD2 Carbohydrate Metabolism - glyoxylate and dicarboxylate; Cofactor and Vitamin Metabolism - one carbon pool by folate; EC 1.5.1.15; EC 3.5.4.9; Hydrolase; Mitochondrial; Oxidoreductase P13995 10797 2p13.1 human K88-ac 1876877400 SHSYVLNkTRAAAVV THF_DHG_CYH enzymatic activity, inhibited 32811824 1 1 0 -RIPK3 RIPK3 EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, Ser/Thr (non-receptor); Protein kinase, TKL Q9Y572 11035 14q12 human K501-ub 1881250302 VGSQEGPkDPEAWSR protein degradation 33953350 1 0 0 TNF-induced necrosis -Ppp2r5b PPP2R5B Motility/polarity/chemotaxis; Protein phosphatase, regulatory subunit Q6PD28 225849 19|19 A mouse S47-p 10405468 RPRRSHSsSQFRYQS molecular association, regulation; phosphorylation PPP2CA(INDUCES); PPP2R5B(INDUCES) 21329884 1 4 7 PPP2R2R5B phosphorylation by CLK2 is required for the PPP2CA-AKT complex; induces AKT dephosphorylation -H1-2 H1C DNA-binding P16403 3006 6p22.2 human K46-ub 486641 PVSELITkAVAASKE Linker_histone carcinogenesis, induced 30517763 1 12 105 -Llgl1 LLGL1 Cell adhesion; Cytoskeletal; Motility/polarity/chemotaxis Q80Y17 16897 11 B2|11 37.81 cM mouse S662-p 449917 LKKSLRQsFRRIRKS intracellular localization 11809830 3 16 8 -RELA NFkB-p65 DNA-binding; Nuclear receptor co-regulator; Transcription factor Q04206 5970 11q13.1 human T322-gl 5148300 KSPFSGPtDPRPPPR molecular association, regulation transcription, induced DNA(INDUCES) 25915426 3 1 0 -MAT1A MAT1A Amino Acid Metabolism - cysteine and methionine; EC 2.5.1.6; Other Amino Acids Metabolism - selenoamino acid; Transferase Q00266 4143 10q22.3 human T202-p 1874404504 VIPVRIHtIVISVQH S-AdoMet_synt_M protein degradation; molecular association, regulation; intracellular localization carcinogenesis, induced; cell motility, induced; cell growth, induced; transcription, induced 14-3-3 zeta(INDUCES) 34349244 1 0 0 -SCN9A SCN9A iso3 Channel, sodium; Membrane protein, integral; Membrane protein, multi-pass Q15858-3 6335 2q24.3 human I848-p 1871432202 LNMLIKIiGNSVGAL Ion_trans activity, induced; protein conformation 33361158 1 0 0 -ADRB1 ADRB1 GPCR, family 1; Membrane protein, integral; Membrane protein, multi-pass; Receptor, GPCR P08588 153 10q25.3 human S312-p 469625 RAGKRRPsRLVALRE 7tm_1 receptor internalization, induced; molecular association, regulation; receptor desensitization, altered; receptor recycling, induced; intracellular localization; receptor recycling, altered DLG1(INDUCES) 14990580; 16940053; 17170109; 24121510; 24324269; 27816670 7 2 0 ADRB1 sorting from endosomes to the plasma membrane -AQP2 AQP2 Channel, misc.; Membrane protein, integral; Membrane protein, multi-pass; Transporter; Transporter, aquaporin family P41181 359 12q13.12 human S261-p 464644 RQSVELHsPQSLPRG molecular association, regulation; intracellular localization exocytosis, induced HSP70(DISRUPTS); VTA1(DISRUPTS) 22778181; 28710278; 29145196; 32529500 38 9 0 -STK11 LKB1 Autophagy; EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, CAMK; Protein kinase, Ser/Thr (non-receptor); Tumor suppressor Q15831 6794 19p13.3 human K64-ac 56714902 EGSYGKVkEVLDSET Pkinase protein degradation; molecular association, regulation; ubiquitination; intracellular localization cell cycle regulation; apoptosis, induced; transcription, induced; cell growth, altered SIRT1(INDUCES); STRAD(DISRUPTS); HERC2(INDUCES) DNA(INDUCES) 27259994 1 0 0 -YAP1 YAP1 Oncoprotein; Transcription, coactivator/corepressor P46937 10413 11q22.1 human K97-sm 6094306 KLPDSFFkPPEPKSH protein stabilization; ubiquitination apoptosis, induced; transcription, induced 19111660 1 0 0 inhibits ubiquitination -ARHGEF2 ARHGEF2 GEF; GEF, Rac/Rho; Motility/polarity/chemotaxis Q92974 9181 1q22 human S151-p 1211018 LSLAKSVsTTNIAGH activity, induced; molecular association, regulation; intracellular localization cell adhesion, induced; cytoskeletal reorganization 14-3-3 zeta(INDUCES); DYNLT1(DISRUPTS) 29089450 1 42 19 -SCFD1 SCFD1 Vesicle Q8WVM8 23256 14q12 human S316-p 27461658 PKRKNKKsYDLTPVD Sec1 molecular association, regulation autophagy, induced PCAF(DISRUPTS) 35465820 1 6 0 SCFD1 phosphorylation promotes its deacetylation -PRKAA1 AMPKA1 Autophagy; EC 2.7.11.1; EC 2.7.11.26; EC 2.7.11.27; EC 2.7.11.31; KINASE; Kinase, protein; Protein kinase, CAMK; Protein kinase, Ser/Thr (non-receptor) Q13131 5562 5p13.1 human K396-ub 21128822 LDELNPQkSKHQGVR enzymatic activity, inhibited 31996460 1 4 0 -Id2 ID2 DNA-binding; Transcription, coactivator/corepressor P41136 15902 12 A1.3|12 8.57 cM mouse T27-p 4706880 LGISRSKtPVDDPMS molecular association, regulation cell growth, inhibited VHL(DISRUPTS) 26735018 3 2 0 -Cdk1 CDK1 Cell cycle regulation; EC 2.7.11.22; EC 2.7.11.23; KINASE; Kinase, protein; Motility/polarity/chemotaxis; Protein kinase, CMGC; Protein kinase, Ser/Thr (non-receptor) P11440 12534 10 B5.3|10 36.07 cM mouse Y15-p 447610 EKIGEGTyGVVYKGR Pkinase enzymatic activity, inhibited cell cycle regulation; carcinogenesis, induced; carcinogenesis, inhibited; carcinogenesis, altered; cell growth, inhibited; cell growth, induced; cell growth, altered 11500387; 1655417; 17554083; 19917613; 32209571; 33761914; 35508654; 36116740; 36223752; 36959566 201 145 3902 -RARG RARG DNA-binding; Nuclear receptor P13631 5916 12q13.13 human S79-p 455544 EMVPSSPsPPPPPRV activity, induced transcription, induced 10748061 3 0 0 Transactivation of mRARb2 promoter -PPP1R12A MYPT1 Motility/polarity/chemotaxis; PHOSPHATASE; Protein phosphatase, regulatory subunit O14974 4659 12q21.2-q21.31 human S585-gl 1868585003 SAAGLQKsLLSSTST molecular association, regulation; phosphorylation cell cycle regulation PLK1(DISRUPTS) 32295844 1 1 0 inhibits CDK1-dependent phosphorylation at MYPT1 S473, regulates mitotic progression and centrosome integrity -Ctnnb1 CTNNB1 Actin-binding; Cell adhesion; Motility/polarity/chemotaxis; Nuclear receptor co-regulator; Oncoprotein; Transcription factor Q02248 12387 9 F4|9 72.19 cM mouse Y670-p 469563 SEDKPQDyKKRLSVE activity, induced carcinogenesis, induced; transcription, induced 37029299 3 1 15 -AKT1 Akt1 EC 2.7.11.1; KINASE; Kinase, protein; Oncoprotein; Protein kinase, AGC; Protein kinase, Ser/Thr (non-receptor) P31749 207 14q32.33 human T305-gl 25538002 EGIKDGAtMKTFCGT Pkinase enzymatic activity, inhibited; phosphorylation 22629392 1 1 0 suppresses Akt phosphorylation at T308 by disrupting its interaction with PDK1 -Lpin1 LPIN1 EC 3.1.3.4; Phosphatase, lipid Q91ZP3 14245 12 A1.1|12 7.9 cM mouse S287-p 471347 PSTPKSDsELVSKSA molecular association, regulation; intracellular localization 14-3-3 beta(INDUCES) 30617183 2 6 0 -ACTR2 ARP2 Actin-binding; Cytoskeletal; Motility/polarity/chemotaxis P61160 10097 2p14 human T237-p 36440502 EQKLALEtTVLVESY Actin intracellular localization carcinogenesis, induced; cell motility, induced; cytoskeletal reorganization 25601402; 27872092; 33755220 5 0 0 -MFF MFF Membrane protein, integral; Mitochondrial Q9GZY8 56947 2q36.3 human S157-p 470754 LKRERSMsENAVRQN Miff molecular association, regulation 14-3-3 beta(INDUCES) 21725060 2 51 55 mutation of this site prevents 14-3-3 binding (pan-14-3-3 antibody) -Syk Syk EC 2.7.10.2; KINASE; Kinase, protein; Protein kinase, TK; Protein kinase, tyrosine (non-receptor) Q64725 25155 17p14 rat Y342-p 447659 LPMDTEVyESPYADP enzymatic activity, induced 12417718 15 12 112 -Pde4d PDE4D EC 3.1.4.53; Nucleotide Metabolism - purine; Phosphodiesterase Q01063 238871 13 D2.1|13 59.69 cM mouse S136-p 483644 SFLYRSDsDYDLSPK phosphorylation; enzymatic activity, induced 25918234 3 24 3 regulates CAMP concentration and insulin secretion, regulates phosphorylation of CRTCs -Axin1 axin 1 Adaptor/scaffold; Tumor suppressor O35625 12005 17 A3.3|17 13.07 cM mouse K861-sm 2407409 KIIGKVEkVD_____ protein stabilization; enzymatic activity, induced 12223491; 18632848 2 0 0 induces JNK activity; prevents ubiquitination -Tbx21 TBX21 DNA-binding; Transcription factor Q9JKD8 57765 11|11 D mouse Y76-p 64227001 RFLGSFAyPPRAQVA transcription, induced 28424242 1 1 0 induce IFN-gamma expression -YAP1 YAP1 Oncoprotein; Transcription, coactivator/corepressor P46937 10413 11q22.1 human K90-ub 964556214 TVPMRLRkLPDSFFK protein degradation carcinogenesis, altered 36271031 2 1 0 -Mlxipl ChREBP Transcription factor Q8VIP2 171078 12q12 rat S627-p 458375 SGSERRPsGDLNSIQ transcription, altered 11698644 2 12 0 inhibits the DNA-binding activity of ChREBP -IGF2BP1 IGF2BP1 RNA-binding; Translation Q9NZI8 10642 17q21.32 human K450-ub 15390813 PPETPDSkVRMVIIT KH_1 carcinogenesis, induced; cell growth, induced 34779401 1 8 14 hepatocarcinogenesis -DLG4 PSD-95 Adaptor/scaffold P78352 1742 17p13.1 human Y397-p 473889 AQYKPEEySRFEAKI molecular association, regulation; protein conformation Stargazin(INDUCES) 24587199; 28692247 3 1 6 regulates binding affinity; phosphorylation at Y397 induced a signi?cant increase in a?nity -GORASP2 GRASP55 Motility/polarity/chemotaxis; Vesicle Q9H8Y8 26003 2q31.1 human K50-ac 33349525 INGSRLNkDNDTLKD molecular association, regulation GRASP55(DISRUPTS) 31604796 1 2 0 Golgi fragmentation, K50 deacetylation is required for post-mitotic Golgi structure formation, GRASP55 deacetylation facilitates self-interaction -RPS6KB1 p70S6K iso2 EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, AGC; Protein kinase, Ser/Thr (non-receptor); Translation P23443-2 6198 17q23.1 human S424-p 448357 GSPRTPVsPVKFSPG protein conformation 30612880 102 54 247 -Rhoa RHOA G protein; G protein, monomeric; G protein, monomeric, Rho; Motility/polarity/chemotaxis; Oncoprotein Q9QUI0 11848 9|9 F1-F2 mouse Y42-p 150180312 VPTVFENyVADIEVD Ras molecular association, regulation cell growth, induced VAV2(INDUCES); RhoGDI alpha(DISRUPTS); IKKG(INDUCES) 28712859 7 0 0 may be involved in tumorigenesis -Plk1 PLK1 EC 2.7.11.21; KINASE; Kinase, protein; Protein kinase, Other; Protein kinase, Ser/Thr (non-receptor) Q07832 18817 7 F2|7 65.52 cM mouse T210-p 448139 YEGERKKtLCGTPNY Pkinase intracellular localization; enzymatic activity, induced cell cycle regulation 25658810; 26755576; 33901174 59 31 45 -SNCAIP SNCAIP Vesicle Q9Y6H5 9627 5q23.2 human S215-p 2873901 CVLSPVKsPHLRKAS molecular association, regulation PIN1(INDUCES) 16365047 1 0 0 -FRS2 FRS2 Adaptor/scaffold Q8WU20 10818 12q15 human Y392-p 449785 NLDPMHNyVNTENVT molecular association, regulation cell differentiation, induced SOS1(INDUCES); GRB2(INDUCES) 11278583 3 2 26 -Kcnk18 KCNK18 Channel, ligand-gated; Channel, potassium; Membrane protein, integral; Membrane protein, multi-pass Q6VV64 332396 19|19 D3 mouse S274-p 13383300 ELVLGRLsCSILSNL activity, inhibited 20215114; 22145024 4 0 0 K+ channel activity inhibited -Map2 MAP2 iso3 Cytoskeletal; Motility/polarity/chemotaxis P15146-3 25595 9q32 rat T262-p 450182 RTPGTPGtPSYPRTP cytoskeletal reorganization 10826493 3 19 17 caused decrease in microtubule bundles -CDK12 CDK12 Cell cycle regulation; EC 2.7.11.22; EC 2.7.11.23; KINASE; Kinase, protein; Motility/polarity/chemotaxis; Protein kinase, CMGC; Protein kinase, Ser/Thr (non-receptor); RNA splicing; Spliceosome Q9NYV4 51755 17q12 human T893-p 472551 SEESRPYtNKVITLW Pkinase protein conformation; enzymatic activity, induced 24662513 1 55 27 -CCNA2 CCNA2 Cell cycle regulation; Nuclear receptor co-regulator P20248 890 4q27 human K95-ac 7761216 PPWKANSkQPAFTIH Cyclin_N2 protein degradation; molecular association, regulation cell cycle regulation CDK2(DISRUPTS) 19483727; 23760262 2 1 0 -Map4 MAP4 Cytoskeletal; Motility/polarity/chemotaxis P27546 17758 9 F2|9 59.83 cM mouse S1046-p 470381 KAQAKVGsLDNVGHL Tubulin-binding molecular association, regulation cytoskeletal reorganization MAP4(INDUCES) 34040253 3 88 1 regulates microtubule detyrosination -Ceacam20 CEACAM20 Immunoglobulin superfamily; Membrane protein, integral Q9D2Z1 71601 7|7 A3 mouse Y559-p 41604100 GRNEESNyEKLLNSN transcription, induced 26195794 1 1 0 increase in IL-8 production -NHERF1 NHERF Adaptor/scaffold; Motility/polarity/chemotaxis O14745 9368 17q25.1 human S302-p 468296 EELNSQDsPPKQDST EBP50_C molecular association, regulation; protein conformation cell cycle regulation; cell growth, inhibited; apoptosis, induced; cytoskeletal reorganization; cell adhesion, inhibited ACTB(INDUCES) 23775624; 30326259 4 36 45 increased cell invasion, regulates invadopodial activity, cell proliferation inhibited, development of VM network, regulates metastatic potency and organotropism -SMN1 SMN RNA processing; RNA-binding Q16637 6606 5q13.2 human S28-p 454315 FRRGTGQsDDSDIWD SMN activity, induced; molecular association, regulation; intracellular localization coilin(INDUCES); SMN(INDUCES) 15592453; 20878088; 24602413 3 78 27 -F2RL1 F2RL1 GPCR, family 1; Membrane protein, integral; Membrane protein, multi-pass; Receptor, GPCR P55085 2150 5q13.3 human S389-p 34607194 KSSSYSSsSTTVKTS receptor desensitization, induced; molecular association, regulation; phosphorylation signaling pathway regulation ARRB1(INDUCES); ARRB2(INDUCES) 33073187 1 0 1 inhibits ERK phosphorylation and signaling; regulates calcium signaling -PRDX6 PRDX6 Amino Acid Metabolism - phenylalanine; EC 1.11.1.15; EC 1.11.1.9; Energy Metabolism - methane; Oxidoreductase; Phospholipase P30041 9588 1q25.1 human K122-sm 62925700 GMLDPAEkDEKGMPV AhpC-TSA sumoylation; protein degradation 28055018 1 0 0 -Creb1 CREB DNA-binding; Transcription factor Q01147 12912 1 C2|1 32.74 cM mouse S129-p 448548 KILNDLSsDAPGVPR pKID neural plasticity; transcription, induced 34607805 5 1 0 -CCND2 CCND2 Cell cycle regulation; Motility/polarity/chemotaxis P30279 894 12p13.32 human T280-p 469202 DELDQAStPTDVRDI Cyclin_C protein degradation cell cycle regulation; cell growth, inhibited 17486076; 24705253; 27843138 4 3 11 phosphodeficient mutants show increased proliferation; CCND2 T280A significantly increased cell growth -IRF1 IRF1 Transcription factor; Tumor suppressor P10914 3659 5q31.1 human K39-ub 31914112 MIFQIPWkHAAKHGW IRF protein degradation; molecular association, regulation DNA(DISRUPTS) 23134341 1 2 0 -DHCR24 Diminuto EC 1.3.1.72; Lipid Metabolism - steroid biosynthesis; Membrane protein, integral; Oxidoreductase Q15392 1718 1p32.3 human T110-p 476314 RVGKYKKtHKNIMIN FAD_binding_4 enzymatic activity, induced 24363437 1 1 1 -RB1 Rb Nuclear receptor co-regulator; Oncoprotein; Transcription, coactivator/corepressor; Tumor suppressor P06400 5925 13q14.2 human S608-p 447976 TAADMYLsPVRSPKK molecular association, regulation; protein conformation cell cycle regulation; cell growth, induced; apoptosis, inhibited E2F1(DISRUPTS); RAF1(INDUCES) 20223825; 22279936; 27331409; 9315635 13 10 30 -LIMD1 LIMD1 Motility/polarity/chemotaxis; Tumor suppressor Q9UGP4 8994 3p21.31 human S424-p 3214995 VLLDSPSsPRVRLPC cell cycle regulation; carcinogenesis, inhibited; cell growth, inhibited; cell motility, inhibited 30600590 1 12 3 mitotic phosphorylation required for mitotic progression -PRPS2 PRPS2 Carbohydrate Metabolism - pentose phosphate pathway; EC 2.7.6.1; Kinase, other; Nucleotide Metabolism - purine P11908 5634 Xp22.2 human T285-p 1874748502 EDKMKHCtKIQVIDI Pribosyl_synth protein degradation; molecular association, regulation; ubiquitination carcinogenesis, inhibited; cell growth, inhibited TRAF2(INDUCES) 34465890 1 1 0 -CSF3R GCSFR Membrane protein, integral; Receptor, cytokine Q99062 1441 1p34.3 human Y767-p 451835 TSPGPGHyLRCDSTQ molecular association, regulation; activity, inhibited SHIP(INDUCES); SHC1(INDUCES); STAT3(INDUCES); CISH(INDUCES) 15470047; 16493051 5 0 0 -Syn1 SYN1 Vesicle P09951 24949 Xq11 rat T337-p 486180 SVSGNWKtNTGSAML Synapsin_C molecular association, regulation; intracellular localization neural plasticity; signaling pathway regulation SYP(DISRUPTS) 31148170 1 2 0 regulating glutamate release -BACH2 BACH2 DNA-binding; Transcription factor Q9BYV9 60468 6q15 human K421-sm 2798316 PGLEALCkQEGELDR intracellular localization 18201693 2 0 0 mobility of nuclear domains -ATAT1 ATAT1 ACETYLTRANSFERASE; Acetyltransferase; EC 2.3.1.108 Q5SQI0 79969 6p21.33 human S237-p 1095631200 GDIKPYSsSDREFLK acetylation; enzymatic activity, induced cell growth, inhibited 29703898 1 0 0 -ESR1 ER-alpha DNA-binding; Nuclear receptor; Transcription factor P03372 2099 6q25.1-q25.2 human K299-sm 27992516 WPSPLMIkRSKKNSL transcription, inhibited 22826433 1 1 0 ER-alpha SUMOylation suppresses ER transcriptional activation by full antiestrogens (AEs) in the absence of induced ER degradation -HDAC2 HDAC2 DEACETYLASE; Deacetylase; EC 3.5.1.98; Nuclear receptor co-regulator; Transcription, coactivator/corepressor Q92769 3066 6q21 human K75-ac 11320706 YHSDEYIkFLRSIRP Hist_deacetyl molecular association, regulation; phosphorylation; enzymatic activity, induced transcription, induced lamin A/C(INDUCES); CK2A1(INDUCES) 24526703; 32698523 2 2 0 Lamin A/C binds PCAF and HDAC2 in committed C2C12 ; induces hypertrophic phenotypes in cardiomyocytes, induces phosphorylation at HDAC2- S394 -Mlxipl ChREBP Transcription factor Q99MZ3 58805 5|5 G2 mouse S514-p 4772264 SPGGQKAsPPTLASA transcription, induced 28450420 1 3 0 S514 phosphorylation could enhance ChREBP O-GlcNAcylation -SIRT1 SIRT1 Apoptosis; DEACETYLASE; Deacetylase; EC 3.5.1.-; Nuclear receptor co-regulator Q96EB6 23411 10q21.3 human K499-ub 15397645 RLGGEYAkLCCNPVK protein degradation carcinogenesis, inhibited; cell growth, inhibited; cell motility, inhibited 32361710 1 4 1 -CDCA5 CDCA5 Cell cycle regulation Q96FF9 113130 11q13.1 human T115-p 469416 VPATPTStPVPNPEA Sororin molecular association, regulation; activity, inhibited cell cycle regulation SCC-112(DISRUPTS); H2A.1(DISRUPTS); SMC3(DISRUPTS) 21878504; 23901111 2 6 15 -ASAP1 DDEF1 GAP; GAP, ARF; Motility/polarity/chemotaxis Q9ULH1 50807 8q24.21-q24.22 human Y767-p 450438 RDKQRLSyGAFTNQI cell motility, induced 25682866 5 0 0 -Lrrk2 LRRK2 EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, Ser/Thr (non-receptor); Protein kinase, TKL Q5S006 66725 15|15 E3 mouse S1292-p 13204416 PNEMGKLsKIWDLPL LRR_4 autophagy, induced; apoptosis, induced; signaling pathway regulation 37269951 15 3 0 regulates the LRRK2-RAB10-NLRP3 pathway -Tgfbr1 TGFBR1 EC 2.7.11.30; KINASE; Kinase, protein; Membrane protein, integral; Protein kinase, Ser/Thr (receptor); Protein kinase, TKL; Receptor, misc. Q64729 21812 4 B1|4 26.02 cM mouse S165-p 448244 VPNEEDPsLDRPFIS apoptosis, induced; cell growth, altered 8947046 3 4 0 -HSF1 HSF1 DNA-binding; Transcription factor Q00613 3297 8q24.3 human S216-p 4668102 IPLMLNDsGSAHSMP protein degradation; molecular association, regulation; ubiquitination; intracellular localization cell cycle regulation CDC20(INDUCES) 18794143; 19934326 4 3 1 binding between HSF1 and Cdc20 increases in p53 -/- cells; interaction of Cdc20 with HSF1 weakenes its interaction with Mad2 in the three-protein complex -KIN KIN C2H2-type zinc finger protein; DNA replication O60870 22944 10p14 human K135-m1 27278513 CKVDETPkGWYIQYI Kin17_mid molecular association, regulation; intracellular localization DNA(DISRUPTS) 24140279 1 2 2 relocalization from chromatin to cytosol -HDAC5 HDAC5 DEACETYLASE; Deacetylase; EC 3.5.1.98; Hydrolase Q9UQL6 10014 17q21.31 human S259-p 447995 FPLRKTAsEPNLKVR activity, induced; molecular association, regulation; enzymatic activity, inhibited; intracellular localization cell cycle regulation; apoptosis, induced; transcription, induced; transcription, altered; cell differentiation, altered; chromatin organization, altered; cell growth, induced; cell motility, altered HDAC3(DISRUPTS); 14-3-3 epsilon(INDUCES); TBL1X(DISRUPTS); TBL1XR1(DISRUPTS); GPS2(DISRUPTS); 14-3-3 beta(DISRUPTS); 14-3-3 beta(INDUCES); PRKD3(DISRUPTS); SMRT(DISRUPTS); N-CoR1(INDUCES); PRKD1(DISRUPTS); PRKD2(DISRUPTS) 11081517; 16980613; 18184930; 18332134; 18951085; 21081666; 22243750; 24120667; 24207022; 24841198; 25012661; 28343149; 32485181 25 23 25 -Th TH Amino Acid Metabolism - tyrosine; EC 1.14.16.2; Endoplasmic reticulum; Mitochondrial; Oxidoreductase; Vesicle P04177 25085 1q41 rat S31-p 448544 KQAEAVTsPRFIGRR TOH_N protein stabilization; enzymatic activity, induced 12124439; 1347949; 15228599; 15639226 43 8 0 Phosphorylation of S8 S19 and S31 (more stable) may stabilize TH already phosphorylated at S40 (least stable). -NCOA3 SRC-3 ACETYLTRANSFERASE; Acetyltransferase; EC 2.3.1.48; Motility/polarity/chemotaxis; Nuclear receptor co-regulator; Transcription, coactivator/corepressor Q9Y6Q9 8202 20q13.12 human T1067-p 4252800 LLSNTDAtGLEEIDR Nuc_rec_co-act protein stabilization; molecular association, regulation carcinogenesis, induced; transcription, induced ATF-4(INDUCES); PSMA3(DISRUPTS) DNA(INDUCES) 18313384; 31975428 2 1 0 induces binding to promoters of genes in the purine pathway; some subset of these 8 residues -PTEN PTEN Carbohydrate Metabolism - inositol phosphate; EC 3.1.3.16; EC 3.1.3.48; EC 3.1.3.67; Motility/polarity/chemotaxis; Nuclear receptor co-regulator; PHOSPHATASE; Phosphatase, lipid; Tumor suppressor P60484 5728 10q23.31 human T383-p 448315 HYRYSDTtDSDPENE molecular association, regulation; protein stabilization; intracellular localization; enzymatic activity, inhibited; protein conformation; phosphorylation; enzymatic activity, altered cell cycle regulation; neural plasticity; cell differentiation, altered; carcinogenesis, inhibited; chromatin organization, altered; cell motility, altered; transcription, altered PTEN(INDUCES); PTEN(DISRUPTS); AIP1(DISRUPTS) DNA(INDUCES) 10866658; 11035045; 11431330; 14976311; 17240336; 17565999; 22413754; 24766807; 25823029; 35240162; 36155262 23 3 0 induces EGFR degradation; regulates CHK1 phosphorylation and activation and H2AX phosphorylation -TLR4 TLR4 Membrane protein, integral; Receptor, misc. O00206 7099 9q33.1 human Y674-p 478360 YGRGENIyDAFVIYS TIR molecular association, regulation; phosphorylation transcription, induced IRAK1(DISRUPTS); MYD88(DISRUPTS) 17392283 3 1 0 IRAK1 short form -DRD1 DRD1 GPCR, family 1; Membrane protein, integral; Membrane protein, multi-pass; Receptor, GPCR P21728 1812 5q35.2 human S259-p 455303 ECSQPESsFKMSFKR 7tm_1 molecular association, regulation signaling pathway regulation G-alpha(s)(DISRUPTS); ARR3(INDUCES) 32503917 2 0 0 ERK1/2 activation -Grk2 GRK2 EC 2.7.11.15; KINASE; Kinase, protein; Protein kinase, AGC; Protein kinase, Ser/Thr (non-receptor) Q99MK8 110355 19 A|19 3.98 cM mouse S670-p 447725 KMKNKPRsPVVELSK molecular association, regulation cell motility, altered GIT1(DISRUPTS) 18369319 5 40 18 activates ERK signaling in response to S1P and fibronectin -CDK9 CDK9 Cell cycle regulation; EC 2.7.11.22; EC 2.7.11.23; KINASE; Kinase, protein; Nuclear receptor co-regulator; Protein kinase, CMGC; Protein kinase, Ser/Thr (non-receptor) P50750 1025 9q34.11 human S347-p 3681502 APPRRKGsQITQQST molecular association, regulation RNA(INDUCES) 10958691 3 24 90 HIV-1 TAR RNA -TRIO TRIO Apoptosis; EC 2.7.11.1; GEF; GEF, misc.; KINASE; Kinase, protein; Protein kinase, CAMK; Protein kinase, Ser/Thr (non-receptor) O75962 7204 5p15.2 human S2631-p 4715630 GTLKKSTsWHTALRL cytoskeletal reorganization 35290799 0 10 0 -PELI1 PELI1 Adaptor/scaffold; EC 6.3.2.-; EC 6.3.2.19; Ligase; UBIQUITIN LIGASE; Ubiquitin conjugating system; Ubiquitin ligase Q96FA3 57162 2p14 human S76-p 7388015 ISNKDQHsISYTLSR Pellino ubiquitination; enzymatic activity, induced 19264966 2 1 2 -MEF2C MEF2C DNA-binding; Transcription factor Q06413 4208 5q14.3 human S396-p 456980 NIKSEPVsPPRDRTT sumoylation; protein processing transcription, induced 15340086; 16478538 3 9 0 -Gata4 GATA4 Motility/polarity/chemotaxis; Transcription factor Q08369 14463 14 D1|14 33.24 cM mouse S105-p 449604 AYTPPPVsPRFSFPG GATA-N activity, induced; protein stabilization; molecular association, regulation; protein processing apoptosis, inhibited; transcription, induced; signaling pathway regulation DNA(INDUCES) 11585926; 21746915; 22674427; 23811561; 30793514 16 0 0 signaling pathway related to ECM genes; protein level and cell viability increased; protein ubiquitination decreased; induce testosterone production in male mouse; EPO-ERK signaling -PLK1 PLK1 EC 2.7.11.21; KINASE; Kinase, protein; Protein kinase, Other; Protein kinase, Ser/Thr (non-receptor) P53350 5347 16p12.2 human K492-sm 334535808 YMSEHLLkAGANITP protein stabilization; molecular association, regulation; intracellular localization cell cycle regulation CDH1(DISRUPTS) 29166606 1 0 0 blocking the SUMO acceptor site K492 led to numerous mitotic defects, including misaligned and/or mis-segregated chromosomes; nuclear import -YAP1 YAP1 Oncoprotein; Transcription, coactivator/corepressor P46937 10413 11q22.1 human S131-p 3190651 RAHSSPAsLQLGAVS cell growth, induced; transcription, inhibited 28416665 2 14 59 sensitivity to gemcitabine -SIK2 QIK EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, CAMK; Protein kinase, Ser/Thr (non-receptor) Q9H0K1 23235 11q23.1 human S358-p 487501 DGRQRRPsTIAEQTV molecular association, regulation; intracellular localization carcinogenesis, induced; cell motility, induced; cytoskeletal reorganization 14-3-3 beta(INDUCES) 22462548; 35278271 5 9 134 -PML PML iso4 Nucleolus; Oncoprotein; SUMO LIGASE; SUMO conjugating system; SUMO ligase; Transcription factor; Tumor suppressor; Ubiquitin conjugating system P29590-4 5371 15q24.1 human S40-p 451471 RQPSPSPsPTERAPA protein stabilization apoptosis, altered 15093545 1 10 0 Phosphorylation of PML is associated with enhanced sumoylation and apoptosis induced by As2O3. -GCK GK Carbohydrate Metabolism - amino sugar and nucleotide sugar; Carbohydrate Metabolism - galactose; Carbohydrate Metabolism - glycolysis and gluconeogenesis; Carbohydrate Metabolism - starch and sucrose; EC 2.7.1.2; Kinase, other; Mitochondrial P35557 2645 7p13 human K458-sm 27581517 LVSAVACkKACMLGQ protein stabilization; enzymatic activity, induced 23297408 1 1 0 -DNM1L DRP1 Apoptosis; EC 3.6.5.5; Endoplasmic reticulum; Hydrolase; Microtubule-binding; Mitochondrial; Motor O00429 10059 12p11.21 human K606-sm 9859922 EELLAEEkSKPIPIM activity, induced; intracellular localization 19638400 1 0 0 sumoylation is linked to its GTPase activity cycle, and influenced by DRP1 localization -PRKN PARK2 EC 6.3.2.-; EC 6.3.2.19; Ligase; Translation; Translation regulation; UBIQUITIN LIGASE; Ubiquitin conjugating system; Ubiquitin ligase O60260 5071 6q26 human S101-p 454420 GCEREPQsLTRVDLS phosphorylation 23256036 3 2 0 S9, S10, S101 might be priming phosphorylation sites for S65 phosphorylarion -CACNA1C CACNA1C iso4 Channel, calcium; Membrane protein, integral; Membrane protein, multi-pass P15381-4 rabbit S1570-p 467228 VACKRLVsMNMPLNS GPHH activity, induced 16820363 4 0 0 -MSX1 MSX1 DNA-binding; Motility/polarity/chemotaxis P28360 4487 4p16.2 human K15-sm 12004422 TSLPLGVkVEDSAFG cell differentiation, inhibited; transcription, inhibited 16600910 2 1 0 PIAS1 binding to MSX1 is required for inhibiting cell differentiation and transcriptional repression, but sumoylation is not required -CLASP2 CLASP2 Cytoskeletal; Motility/polarity/chemotaxis O75122 23122 3p22.3 human S1034-p 7990150 SISPFNKsALKEAMF cell cycle regulation 23045552 1 5 0 -Sox2 SOX2 Cell development/differentiation; DNA-binding; Transcription factor P48432 20674 3 A3|3 16.93 cM mouse K247-sm 12004415 GSMGSVVkSEASSSP sumoylation; molecular association, regulation transcription, inhibited DNA(DISRUPTS) 17097055; 19900357 3 0 0 -KCNK2 TREK-1 Channel, potassium; Membrane protein, integral; Membrane protein, multi-pass O95069 3776 1q41 human S348-p 456161 KETRRRLsVEIYDKF activity, inhibited 19622790; 22726831 8 5 0 current reduced by phosphorylation; lidocaine- treated cells -TRPM2 TRPM2 Channel, calcium; EC 3.6.1.13; Hydrolase; Membrane protein, integral; Membrane protein, multi-pass; Transporter O94759 7226 21q22.3 human K1216-ub 1881559700 VPTLASQkAAEEPDA apoptosis, induced 34903714 1 0 0 lncTRPM2-AS blocks the ubiquitylation of TRPM2 and inhibits autophagy induced apoptosis -Prkd2 PRKD2 EC 2.7.11.13; KINASE; Kinase, protein; Motility/polarity/chemotaxis; Protein kinase, CAMK; Protein kinase, Ser/Thr (non-receptor) Q8BZ03 101540 7|7 A2 mouse S711-p 449865 GEKSFRRsVVGTPAY Pkinase exocytosis, induced 21527521 5 28 63 in dense granules, platelet aggregation and thrombus formation -Met Met EC 2.7.10.1; KINASE; Kinase, protein; Membrane protein, integral; Oncoprotein; Protein kinase, TK; Protein kinase, tyrosine (receptor) P16056 17295 6 A2|6 7.83 cM mouse Y1232-p 448470 RDMYDKEyYSVHNKT PK_Tyr_Ser-Thr ubiquitination; enzymatic activity, induced carcinogenesis, induced; cell differentiation, induced; cell motility, induced; cell growth, induced 12244174; 19595710; 34580063; 37175792; 7708691 57 36 740 -STAT1 STAT1 DNA-binding; Transcription factor P42224 6772 2q32.2 human R31-m2 1668800 DSFPMEIrQYLAQWL STAT_int transcription, altered 11257227 1 0 0 -TP53 p53 Activator; DNA-binding; Motility/polarity/chemotaxis; Nuclear receptor co-regulator; Transcription factor; Tumor suppressor P04637 7157 17p13.1 human Y126-p 34824802 AKSVTCTySPALNKM P53 protein degradation; molecular association, regulation; activity, inhibited carcinogenesis, induced; DNA repair, inhibited HERC5(INDUCES) 25071020 1 0 0 promotes ISGylation -FUS hnRNP P2 DNA-binding; Nuclear receptor co-regulator; Oncoprotein; RNA splicing; RNA-binding; SUMO LIGASE P35637 2521 16p11.2 human S164-p 1878186702 QQNQYNSsSGGGGGG molecular association, regulation hnRNP P2(DISRUPTS) 35753345 1 1 0 -Scn5a SCN5A Channel, sodium; Membrane protein, integral; Membrane protein, multi-pass Q9JJV9 20271 9 F3|9 71.33 cM mouse S1937-p 1869500702 FRQQAGSsGLSDEDA activity, induced; molecular association, regulation FGF13(DISRUPTS); Calmodulin(DISRUPTS) 28882890 1 1 0 impairs FGF13-dependent regulation of NaV1.5 channel inactivation -CTNNB1 CTNNB1 Actin-binding; Cell adhesion; Motility/polarity/chemotaxis; Nuclear receptor co-regulator; Oncoprotein; Transcription factor P35222 1499 3p22.1 human K49-ub 486322 TAPSLSGkGNPEEED protein degradation carcinogenesis, inhibited; cell growth, inhibited; transcription, inhibited 16849322 1 0 0 K19 is primary site of ubquitination ; when both sites are mutated induces TCF transcription and transformation -CEBPD C/EBP-delta DNA-binding; Motility/polarity/chemotaxis P49716 1052 8q11.21 human S167-p 28852500 SPEPPRSsPRQTPAP cell motility, induced; transcription, induced 23993701 1 0 0 -SNAPIN SNAPIN Vesicle O95295 23557 1q21.3 human T117-p 28761202 NHSVAKEtARRRAML molecular association, regulation exocytosis, inhibited SNAP-25(DISRUPTS) 23949442 1 0 0 -CCP110 CP110 Cell cycle regulation O43303 9738 16p12.3 human S98-p 126835300 VRKAPNAsDFDQWEM CaM_bind cell cycle regulation 28562169 1 0 0 centrosome duplication -ETS1 Ets-1 DNA-binding; Motility/polarity/chemotaxis; Oncoprotein; Transcription factor P14921 2113 11q24.3 human T265-p 31087093 YDSCDRLtQSWSSQS Ets1_N_flank activity, induced; protein stabilization; molecular association, regulation carcinogenesis, induced; cell motility, induced; transcription, induced; signaling pathway regulation p300(INDUCES) DNA(INDUCES) 34023818 1 2 0 transcriptional activation of matrix metalloproteinase (MMP)-9; inhibits ubiquitination, regulates GSK3?/ETS1/MMP-9 signaling -Eif2s1 eIF2-alpha RNA-binding; Translation; Translation initiation Q6ZWX6 13665 12|12 C3 mouse S52-p 447635 MILLSELsRRRIRSI S1 activity, induced; activity, inhibited apoptosis, induced; transcription, induced; transcription, altered; autophagy, induced; translation, altered; apoptosis, inhibited; cytoskeletal reorganization; translation, induced; cell growth, altered; translation, inhibited 11430820; 12176355; 15184376; 17325203; 18063576; 19181853; 20559319; 20660158; 20924113; 23624402; 26549106; 27409837; 33567340; 34092754; 34560245; 34647267; 35466425; 35501370; 35758650 132 2 0 -Tp53 p53 Activator; DNA-binding; Motility/polarity/chemotaxis; Nuclear receptor co-regulator; Transcription factor; Tumor suppressor P02340 22059 11 B3|11 42.83 cM mouse K369-ub 464660 HSSYLKTkKGQSTSR transcription, altered 15964796 9 0 0 p53K6R (K378/383/369/379/367/370/R) mutant is still ubiquitinated and shows normal stability of p53 before and after DNA damage -Rph3a rabphilin 3A Vesicle P47708 19894 5|5 F mouse S234-p 455904 GPPTRRAsEARMSTA intracellular localization cytoskeletal reorganization 11466418; 28636945 5 0 2 polarization -GYS1 GYS1 Carbohydrate Metabolism - starch and sucrose; EC 2.4.1.11; Transferase P13807 2997 19q13.33 human S645-p 448238 RPASVPPsPSLSRHS Glycogen_syn enzymatic activity, inhibited; activity, inhibited signaling pathway regulation 19339242; 21668450; 22510711; 29541418 21 32 7 regulation of glycogen synthesis via R3F-PP1 signaling in astrocytoma cells -ILK ILK EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, Ser/Thr (non-receptor); Protein kinase, TKL Q13418 3611 11p15.4 human T173-p 479406 DTFWKGTtRTRPRNG intracellular localization cell motility, altered; signaling pathway regulation 17420447; 22521536 7 1 1 PKCA-ILK signaling pathway for growth cone collapse, RGC axon guidance, repulsive axon turning induced by Shh -NFATC1 NFAT2 DNA-binding; Transcription factor O95644 4772 18q23 human S294-p 448863 PHGSPRVsVTDDSWL intracellular localization; activity, inhibited 12351631 1 0 0 -NRBF2 NRBF2 Autophagy; Nuclear receptor co-regulator; Transcription, coactivator/corepressor Q96F24 29982 10q21.3 human S113-p 7446822 AEDAEGQsPLSQKYS NRBF2 molecular association, regulation; enzymatic activity, inhibited autophagy, induced ULK1(DISRUPTS); beclin 1(DISRUPTS); ATG13(DISRUPTS); ATG14(DISRUPTS); PIK3R4(INDUCES); PIK3C3(INDUCES); RB1CC1(DISRUPTS) 28059666 1 11 0 controls ULK1 complex association and PtdIns3K complex assembly, decreases PtdIns3K lipid kinase activity -Kif5b KIF5B Microtubule-binding; Motor Q61768 16573 18 A1|18 4.46 cM mouse S175-p 29603400 CTERFVCsPDEVMDT Kinesin activity, inhibited 24072715 2 1 0 autoinhibition is stabilized, reduces the stall force, tunes the direction of two-motor transport -SP1 SP1 C2H2-type zinc finger protein; DNA-binding; Transcription factor P08047 6667 12q13.13 human S641-p 470040 GKVYGKTsHLRAHLR zf-C2H2 activity, induced; molecular association, regulation transcription, induced; transcription, altered Rb-like 1(DISRUPTS) 16943418; 19464346 3 1 0 -HMGN1 HMGN1 DNA-binding; Nuclear receptor co-regulator P05114 3150 21q22.2 human K55-ac 458851 KKVQTKGkRGAKGKQ HMG14_17 molecular association, regulation DNA(DISRUPTS) 10753971 1 0 0 -BUB1B BUB1B EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, Other; Protein kinase, Ser/Thr (non-receptor); Tumor suppressor O60566 701 15q15.1 human S676-p 767909 LSPIIEDsREATHSS molecular association, regulation; phosphorylation cell cycle regulation; cytoskeletal reorganization PPP2R5A(INDUCES); PPP2CA(INDUCES) 17785528; 20016069; 23079597; 23345399; 27568981; 33207204 9 4 0 T680 is independent of attachment status and may correlate with lack of interkinetochore tension.; regulates KNL1 phosphorylation; regulates chromosome congression; kinetochore-microtubule stability and lack of tension ; chromosome segregation during mitosis and mitotic progression; spindle activation checkpoint (SAC); kinetochore-microtubule attachment -RAPH1 RAPH1 Adaptor/scaffold; Motility/polarity/chemotaxis Q70E73 65059 2q33.2 human Y481-p 54363503 QIQKKSQyIKYLCCD PH molecular association, regulation cell motility, induced 26996666 1 0 0 Lpd-Scar/WAVE interaction is positively regulated by c-Abl and c-Src, breast cancer cell invasion -Rbm20 RBM20 E9PT37 309544 1q55 rat S640-p 31086439 PERPRSRsPMSRSLS RNA splicing, altered 36140694 2 3 0 -Syt7 SYT7 Membrane protein, integral Q62747 59267 1q43 rat S103-p 4758666 RRTEPRSsVSDLVNS exocytosis, induced 26216970 1 1 0 glucose-stimulated insulin secretion, insulin-granule exocytosis -MAP2 MAP2 Cytoskeletal; Motility/polarity/chemotaxis P11137 4133 2q34 human Y67-p 454429 EHGSQGTySNTKENG molecular association, regulation GRB2(INDUCES) 15536091 2 0 1 -PDE4B PDE4B iso2 EC 3.1.4.53; Nucleotide Metabolism - purine; Phosphodiesterase Q07343-2 5142 1p31.3 human S487-p 471380 YQSMIPQsPSPPLDE enzymatic activity, induced 11030732 1 5 0 decreases levels of cAMP -FOXO4 FOXO4 DNA-binding; Oncoprotein; Transcription factor P98177 4303 Xq13.1 human S230-p 471960 PEGATPTsPVGHFAK carcinogenesis, altered; transcription, altered 20959475 1 9 5 -GLE1 GLE1 Karyopherin; Nuclear export Q53GS7 2733 9q34.11 human S92-p 50831365 VPKSPDAsSAFSPAS molecular association, regulation GLE1(INDUCES) 30429220 1 2 0 self-association stress granules' assembly and disassembly, DDX3-ATPase activity inhibited -tao2 TAO2 iso2 Apoptosis; EC 2.7.11.1; KINASE; Kinase, protein; Membrane protein, integral; Membrane protein, multi-pass; Protein kinase, STE; Protein kinase, Ser/Thr (non-receptor) Q9JLS3-2 64666 1q36-q37 rat S1038-p 1308925 AAVPGPLsRSTSVAS intracellular localization endocytosis, altered 17988630 1 0 0 -ATRIP ATRIP Cell cycle regulation; DNA repair, damage; DNA-binding Q8WXE1 84126 3p21.31 human S72-p 454389 TLASQALsQCPAAAR intracellular localization 15451423 1 0 0 -Arhgdia RhoGDI alpha Apoptosis; Cell adhesion; Cell development/differentiation; G protein regulator, misc.; Motility/polarity/chemotaxis Q99PT1 192662 11|11 E2 mouse S96-p 486318 DLTGDLEsFKKQSFV Rho_GDI activity, induced; molecular association, regulation RHOG(DISRUPTS); GIPC1(DISRUPTS) 19581409 3 0 0 ternary complex with syndecan 4 -DDX17 DDX17 iso3 EC 3.6.4.13; Helicase; Nuclear receptor co-regulator; Nucleolus; RNA processing; RNA-binding; Spliceosome; Transcription, coactivator/corepressor Q92841-3 10521 22q13.1 human K50-sm 12726300 WDLSELPkFEKNFYV protein stabilization; molecular association, regulation transcription, inhibited HDAC1(INDUCES) 19995069 1 2 0 estrogen receptor and p53 transcription -HNRNPK hnRNP K RNA splicing; RNA-binding; Spliceosome P61978 3190 9q21.32 human Y72-p 455999 IKALRTDyNASVSVP KH_1 translation, altered 12052863 3 6 0 based on Y72/225/230/234/236/380A mutant -Etv4 ETV4 DNA-binding P28322 18612 11 D|11 65.48 cM mouse K302-ac 26373305 VMGYGYEkSLRPFPD ETS_PEA3_N sumoylation transcription, induced 21543453 1 1 0 acetylated sites inhibits sumoylation reciprocally -Elavl1 HuR RNA-binding P70372 15568 8 A1.1|8 2.0 cM mouse S221-p 478357 QAQRFRFsPMGVDHM molecular association, regulation; intracellular localization transcription, induced Exportin-1(INDUCES); TNFSF13(INDUCES); ANP32A(INDUCES) RNA(INDUCES) 30016500 11 0 0 -STAT2 STAT2 DNA-binding; Transcription factor P52630 6773 12q13.3 human T404-p 1869973803 IWDFGYLtLVEQRSG STAT_bind protein stabilization; molecular association, regulation; intracellular localization; protein conformation; phosphorylation carcinogenesis, induced; transcription, induced; transcription, inhibited; signaling pathway regulation IRF9(INDUCES); STAT1(DISRUPTS); STING(INDUCES) 32759968; 37036972 2 1 0 inhibits phosphorylation of STING and IRF3, inhibits nuclear translocation of IRF3, thus inhibiting the STING?IRF3 pathway; regulation of antiviral defense mechanism; IFN-1 signaling -ZC3HC1 NIPA Cell cycle regulation; Ubiquitin conjugating system Q86WB0 51530 7q32.2 human T387-p 3204981 RSMGTGDtPGLEVPS molecular association, regulation; intracellular localization cell growth, induced NPM-ALK(DISRUPTS) 31434245 1 18 5 -PNKD PNKD iso2 EC 3.-.-.-; Hydrolase Q8N490-2 25953 2q35 human S46-p 35486502 RALQSHSsPEGKEEP molecular association, regulation carcinogenesis, induced ERK1(INDUCES); MEK1(INDUCES) 25066297 1 1 0 activation of MEK/ERK signaling pathway -SLC39A4 SLC39A4 Membrane protein, integral; Membrane protein, multi-pass; Transporter; Transporter, SLC family Q6P5W5 55630 8q24.3 human K463-ub 1877047302 PSELRQPkPPHEGSR Zip protein degradation 32348750 1 0 0 zinc-induced degradation, but not zinc-dependent endocytosis -Ppp1ca PPP1CA EC 3.1.3.16; Nucleolus; PHOSPHATASE; Protein phosphatase, Ser/Thr (non-receptor) P62138 24668 1q43 rat T320-p 448686 NPGGRPItPPRNSAK enzymatic activity, inhibited 24189275 24 43 98 LTD (long-term depression) induction -SQSTM1 SQSTM1 Autophagy; Nuclear receptor co-regulator; Ubiquitin conjugating system Q13501 8878 5q35.3 human S272-p 454787 RSRLTPVsPESSSTE protein degradation; molecular association, regulation; ubiquitination; intracellular localization cell cycle regulation; carcinogenesis, induced; carcinogenesis, altered; autophagy, inhibited; signaling pathway regulation mTOR(INDUCES); LC3B(DISRUPTS); Raptor(INDUCES); TRAF6(INDUCES) 20974803; 26279575; 35840557 9 80 278 -Csf1r CSFR EC 2.7.10.1; KINASE; Kinase, protein; Membrane protein, integral; Oncoprotein; Protein kinase, TK; Protein kinase, tyrosine (receptor) P09581 12978 18 E1|18 34.41 cM mouse Y921-p 455145 LERRDQDyANLPSSG molecular association, regulation cytoskeletal reorganization; cell growth, altered GRB2(INDUCES) 9380408 3 1 1 -Stat3 STAT3 DNA-binding; Motility/polarity/chemotaxis; Nuclear receptor co-regulator; Transcription factor P42227 20848 11 D|11 63.82 cM mouse K383-ac 36313373 AALRGSRkFNILGTN STAT_bind molecular association, regulation transcription, induced; signaling pathway regulation NFkB-p65(INDUCES) 28637784 1 1 2 signaling to improve mitochondrial fusion and function; K383 may induce stronger binding, enhanced OPA1 expression -CSNK1E CK1E EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, CK1; Protein kinase, Ser/Thr (non-receptor) P49674 1454 22q13.1 human T44-p 14694702 IKLECVKtKHPQLHI Pkinase enzymatic activity, induced 20507565 1 0 0 -GCK GK Carbohydrate Metabolism - amino sugar and nucleotide sugar; Carbohydrate Metabolism - galactose; Carbohydrate Metabolism - glycolysis and gluconeogenesis; Carbohydrate Metabolism - starch and sucrose; EC 2.7.1.2; Kinase, other; Mitochondrial P35557 2645 7p13 human K346-sm 27581515 ESDTGDRkQIYNILS Hexokinase_2 protein stabilization; enzymatic activity, induced 23297408 1 1 0 -Ppp1r12a MYPT1 Motility/polarity/chemotaxis; PHOSPHATASE; Protein phosphatase, regulatory subunit Q9DBR7 17931 10 D1|10 56.33 cM mouse T852-p 452075 PREKRRStGVSFWTQ enzymatic activity, inhibited 30377223 44 2 17 -MVB12A FAM125A Adaptor/scaffold Q96EY5 93343 19p13.11 human S232-p 483399 RFEGKSCsPLAFSAF DUF2464 protein processing 18005716 1 8 0 inhibition of HIV-1 release and infectivity -PPARD PPAR-delta DNA-binding; Nuclear receptor Q03181 5467 6p21.31 human Y108-p 1868968410 TIRMKLEyEKCERSC zf-C4 molecular association, regulation carcinogenesis, induced; cell growth, induced; autophagy, inhibited LC3B(INDUCES) 32439863 1 1 0 -SEC63 SEC63 Endoplasmic reticulum; Membrane protein, integral; Membrane protein, multi-pass Q9UGP8 11231 6q21 human S576-p 27440600 VSDKGSDsEEEETNR molecular association, regulation SEC62(INDUCES) 23287549 1 1 0 -Mavs MAVS Adaptor/scaffold; Membrane protein, integral Q8VCF0 228607 2|2 F1 mouse S328-p 143281202 TAPSKLPsNSVYAGT transcription, induced 28725479 1 1 0 -Klhl3 KLHL3 Actin-binding; Cytoskeletal E0CZ16 100503085 13|13 B1 mouse S433-p 36440206 PMNTRRSsVGVGVVE Kelch_1 activity, induced; protein stabilization; phosphorylation 30914436 6 2 0 induces WNK stability, SPAK/OSR1 phosphorylation subsequently increasing NCC phosphorylation and activity -CREB1 CREB DNA-binding; Transcription factor P16220 1385 2q33.3 human S94-p 451807 QISTIAEsEDSQESV molecular association, regulation; phosphorylation CBP(INDUCES) 17209043 8 2 1 mutation to alanine decreases S121 phosphorylation in cells treated with ionizing radiation -LCP2 SLP76 Adaptor/scaffold Q13094 3937 5q35.1 human Y113-p 448218 SSFEEDDyESPNDDQ molecular association, regulation; phosphorylation cytoskeletal reorganization; transcription, induced; signaling pathway regulation NCK1(INDUCES); ITK(INDUCES); PIK3R1(INDUCES); VAV1(INDUCES) 11046020; 12817019; 15388330; 17148460; 21725281; 22534133; 22786724; 23901140 17 0 0 transcriptional activity of NFAT and AP-1; regulates NK cell activation -JAM3 JAM3 Cell adhesion; Membrane protein, integral Q9BX67 83700 11q25 human S281-p 15404111 NNKQDGEsYKNPGKP intracellular localization 28196865 1 0 19 cell-cell contact region, S-palmitoylation of JAM3 is independent of JAM3 phosphorylation on Ser281 -CDT1 CDT1 DNA replication; DNA-binding; Motility/polarity/chemotaxis; Oncoprotein Q9H211 81620 16q24.3 human T406-p 21440503 LPATPPAtPPAASPS protein stabilization; molecular association, regulation; activity, inhibited; phosphorylation RAMP(DISRUPTS); MCM2(DISRUPTS) 21930785; 32841231 2 1 1 inhibits Chk1 phosphorylation -Fhl1 FHL1 iso2 Cell development/differentiation P97447-2 14199 X|X A6 mouse K171-sm 3278910 KCNKGLVkAPVWWPM transcription, induced; signaling pathway regulation 17509614 1 0 0 induces Notch signaling pathway -ESR1 ER-alpha DNA-binding; Nuclear receptor; Transcription factor P03372 2099 6q25.1-q25.2 human S305-p 448805 IKRSKKNsLALSLTA activity, induced; protein stabilization; molecular association, regulation; acetylation; intracellular localization; protein conformation; phosphorylation carcinogenesis, induced; carcinogenesis, altered; cell growth, induced; transcription, induced; transcription, altered; cell growth, altered AKAP13(INDUCES); NRIF3(INDUCES); ER-alpha(INDUCES) 12374744; 15193262; 15604293; 16452229; 17068199; 17627277; 18521086; 20101208; 20179234; 24166501; 24449872; 26272591; 26554417 16 0 0 ER-alpha-dependent transcription -NR1I2 PXR DNA-binding; Nuclear receptor O75469 8856 3q13.33 human S8-p 9730705 MEVRPKEsWNHADFV molecular association, regulation transcription, altered RXRA(DISRUPTS) 19617467 1 0 0 inhibits transcription -EGFR EGFR EC 2.7.10.1; KINASE; Kinase, protein; Membrane protein, integral; Oncoprotein; Protein kinase, TK; Protein kinase, tyrosine (receptor) P00533 1956 7p11.2 human S991-p 455701 DERMHLPsPTDSNFY molecular association, regulation; receptor internalization, altered; phosphorylation ubiquitin(INDUCES); CBL(INDUCES) 19531499 2 34 8 -DDR1 DDR1 EC 2.7.10.1; KINASE; Kinase, protein; Membrane protein, integral; Protein kinase, TK; Protein kinase, tyrosine (receptor) Q08345 780 6p21.33 human Y740-p 458377 AQGPTISyPMLLHVA PK_Tyr_Ser-Thr molecular association, regulation SHP-2(INDUCES); NCK2(INDUCES) 16337946 1 0 0 -SRC Src EC 2.7.10.2; KINASE; Kinase, protein; Oncoprotein; Protein kinase, TK; Protein kinase, tyrosine (non-receptor) P12931 6714 20q11.23 human S70-p 2192576 LFGGFNSsDTVTSPQ receptor internalization, induced; enzymatic activity, induced transcription, induced 27169346 1 2 0 ISO induced EGFR internalization, ADRB2 mediated EGFR transactivation -NCAPG NCAPG Cell cycle regulation Q9BPX3 64151 4p15.31 human T332-p 5014904 LIPVETLtPEIALYW molecular association, regulation; intracellular localization DNA(INDUCES) 18977199 1 0 0 regulates NCAPG localization with chromosomal DNA in mitotic cells -INSR INSR iso2 EC 2.7.10.1; KINASE; Kinase, protein; Membrane protein, integral; Protein kinase, TK; Protein kinase, tyrosine (receptor) P06213-2 3643 19p13.2 human S989-p 449888 SSNPEYLsASDVFPC activity, induced 1656240 1 0 0 mutation of site impairs insulin stimulation of PI3K activity. -PPARG PPAR-gamma iso2 DNA-binding; Nuclear receptor; Transcription factor P37231-2 5468 3p25.2 human Y74-p 9256871 YDLKLQEyQSAIKVE PPARgamma_N protein degradation; molecular association, regulation; ubiquitination carcinogenesis, induced; cell growth, induced; apoptosis, inhibited; signaling pathway regulation MDM2(INDUCES) 26718225 2 0 1 Y74 mutant inhibits EGFR/NFkB signaling-mediated gene expression -ADRB2 ADRB2 GPCR, family 1; Membrane protein, integral; Membrane protein, multi-pass; Receptor, GPCR P07550 154 5q32 human Y326-p 451497 SGFNPLIyCRSPDFR 7tm_1; TM receptor internalization, induced 9145918 3 0 0 sequestration -DGCR8 DGCR8 Nucleolus; RNA processing; RNA-binding Q8WYQ5 54487 22q11.21 human S434-p 27447299 VEVCKDEsVDLEEFR protein stabilization 24239349 1 5 0 -F2R PAR1 Cell development/differentiation; GPCR, family 1; Membrane protein, integral; Membrane protein, multi-pass; Receptor, GPCR P25116 2149 5q13.3 human S391-p 3627501 SILCCKEsSDPSSYN receptor desensitization, altered 10413505 1 0 0 receptor shutoff (not internalization) -STAT1 STAT1 DNA-binding; Transcription factor P42224 6772 2q32.2 human K511-ub 12109287 WQFSSVTkRGLNVDQ ubiquitination IFNAR2(DISRUPTS) 32123171 1 2 4 linear ubiquitination of K511 and K652 and inhibits interaction with INFAR2, INF-I stimulation removes STAT1 linear ubiquitination, viruses upregulate HOIP and STAT1 linear ubiquitination -Slc14a2 SLC14A2 Membrane protein, integral; Membrane protein, multi-pass; Transporter; Transporter, SLC family Q62668 54302 18q12.3 rat S499-p 2813500 WSSIRRRsKVFGKSE activity, induced; molecular association, regulation; intracellular localization SNAPIN(INDUCES) 18495802; 20457831; 25377918 6 0 0 apical plasma membrane accumulation -RIPK3 RIPK3 EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, Ser/Thr (non-receptor); Protein kinase, TKL Q9Y572 11035 14q12 human T224-p 50788489 GREVELPtEPSLVYE Pkinase molecular association, regulation MLKL(INDUCES) 35739084 1 3 0 -PFKFB2 PFKFB2 Carbohydrate Metabolism - fructose and mannose; EC 2.7.1.105; EC 3.1.3.46; Kinase, other; Motility/polarity/chemotaxis; Phosphatase (non-protein) O60825 5208 1q32.1 human S32-p 23003811 EKKCSWAsYMTNSPT 6PF2K molecular association, regulation; enzymatic activity, inhibited; intracellular localization transcription, altered FBPase 2(INDUCES) 22214556; 24566088; 24634222 3 0 0 -PTK2B Pyk2 EC 2.7.10.2; KINASE; Kinase, protein; Nuclear receptor co-regulator; Protein kinase, TK; Protein kinase, tyrosine (non-receptor) Q14289 2185 8p21.2 human Y881-p 447958 DRTDDLVyLNVMELV Focal_AT molecular association, regulation GRB2(INDUCES) 23612968 17 0 1 Grb2 recruitment to SHPS1 -Mecp2 MECP2 Transcription, coactivator/corepressor Q9Z2D6 17257 X A7.3|X 37.63 cM mouse S164-p 481659 FTVTGRGsPSRREQK molecular association, regulation; intracellular localization cell differentiation, altered DNA(DISRUPTS) 27323888 1 2 0 accumulation at heterochromatic foci, P-S164 MeCP2 shows altered nucleosome binding, neuronal dendritic branching and nuclear size -Scn10a SCN10A Channel, sodium; Membrane protein, integral; Membrane protein, multi-pass Q62968 rat S551-p 2482300 QTGPLPRsPLPQSPN activity, induced 18354022 1 0 0 increases SCN10A sodium channel current density -Hoxa9 HOXA9 DNA-binding; Oncoprotein P09631 15405 6 B3|6 25.4 cM mouse S204-p 2906100 ANWLHARsTRKKRCP molecular association, regulation cell differentiation, altered DNA(DISRUPTS) 15082777 1 0 0 -HMCN1 HMCN1 Cell adhesion; Extracellular matrix; Secreted; Secreted, signal peptide Q96RW7 83872 1q25.3-q31.1 human K266-ub 52485008 EIRNPLGkLIKKGFG protein degradation 26676607 0 1 0 -Gabrg2 GABRG2 Channel, chloride; Channel, ligand-gated; Membrane protein, integral; Membrane protein, multi-pass; Transporter; Transporter, ion channel Q6PW52 29709 10q21 rat Y413-p 455818 ERDEEYGyECLDGKD Neur_chan_memb molecular association, regulation; receptor internalization, inhibited neural plasticity; endocytosis, inhibited Src(INDUCES); AP-2 alpha(DISRUPTS) 11640929; 18305175 7 0 0 -Vim Vimentin Cytoskeletal; Motility/polarity/chemotaxis P20152 22352 2 A1|2 10.04 cM mouse S459-p 470128 GQVINETsQHHDDLE cytoskeletal reorganization; endocytosis, inhibited 24196446 5 52 37 required for the inhibition of endocytotic vesicle fusion in mitosis, integrin trafficing toward the clevage furrow -ADD1 ADD1 Cytoskeletal; Motility/polarity/chemotaxis P35611 118 4p16.3 human S355-p 456832 KYKAKSRsPGSPVGE molecular association, regulation cytoskeletal reorganization MYO10(INDUCES) 24379415 2 32 4 association with mitotic spindles -Slc9a1 NHE1 Membrane protein, integral; Membrane protein, multi-pass; Motility/polarity/chemotaxis; Transporter; Transporter, SLC family P26431 24782 5q36 rat S652-p 3880766 KTRQRLRsYNRHTLV NEXCaM_BD activity, induced cytoskeletal reorganization; cell growth, altered 19622752 4 2 6 -CDKN1A p21Cip1 Cell cycle regulation; Inhibitor P38936 1026 6p21.2 human T57-p 451222 NFDFVTEtPLEGDFA CDI protein degradation; molecular association, regulation; protein stabilization; ubiquitination; intracellular localization; phosphorylation cell cycle regulation; apoptosis, induced CDK4(DISRUPTS) 11779850; 19364816; 19822666; 23737759; 23745637 8 0 0 -PKD2L1 PKD2L1 Channel, cation; Membrane protein, integral; Membrane protein, multi-pass; Motility/polarity/chemotaxis Q9P0L9 9033 10q24.31 human S686-p 394791407 LGRSIVSsPQGKSGP activity, induced 29230552 1 0 0 regulates the channel activity -CDC25A CDC25A EC 3.1.3.48; Motility/polarity/chemotaxis; PHOSPHATASE; Protein phosphatase, dual-specificity P30304 993 3p21.31 human S293-p 449128 GSTKRRKsMSGASPK M-inducer_phosp protein degradation 12676583 2 1 1 -Pdha1 PDHA1 Amino Acid Metabolism - valine, leucine and isoleucine biosynthesis; Carbohydrate Metabolism - butanoate; Carbohydrate Metabolism - citrate (TCA) cycle; Carbohydrate Metabolism - glycolysis and gluconeogenesis; Carbohydrate Metabolism - pyruvate; EC 1.2.4.1; Mitochondrial; Oxidoreductase P35486 18597 X F4|X 73.95 cM mouse S232-p 448257 NRYGMGTsVERAAAS E1_dh enzymatic activity, inhibited cell cycle regulation; signaling pathway regulation 21775648; 28632902; 30726738; 34988082; 36211560 45 79 7 -AR AR DNA-binding; Nuclear receptor; Transcription factor P10275 367 Xq12 human R407-p 23303205 AAAAAQCrYGDLASL Androgen_recep molecular association, regulation; protein conformation transcription, inhibited 22334658 1 0 0 AR N/C interaction-dependent transcriptional activity -CPEB3 CPEB3 RNA-binding Q8NE35 22849 10q23.32 human K46-sm 1877467600 PLSSETPkPEENSAV molecular association, regulation ACTB(DISRUPTS) 32848053 1 0 0 SUMOylation of CPEB3 is a potential inhibitor for the CPEB3/F-actin interaction -PSMC3 RPT5 Nuclear receptor co-regulator; Proteasome complex; Transcription, coactivator/corepressor P17980 5702 11p11.2 human Y381-p 55371058 NVSPDVNyEELARCT AAA_lid_3 protein stabilization 28435470 1 2 0 -RRN3 TIF1A Nucleolus; Transcription initiation complex Q9NYV6 54700 16p13.11 human S172-p 470002 GDVDVSDsDDEDDNL RRN3 activity, induced; protein stabilization; molecular association, regulation; intracellular localization cell cycle regulation; chromatin organization, altered; transcription, induced POLM(DISRUPTS); TWISTNB(DISRUPTS) DNA(INDUCES) 18559419; 24297901; 27257073 3 24 2 rDNA transcription; rRNA synthesis induced -Dlg4 PSD-95 Adaptor/scaffold Q62108 13385 11|11 B3 mouse K558-ub 3933139 LLSEFPDkFGSCVPH Guanylate_kin molecular association, regulation neural plasticity; cytoskeletal reorganization GKAP1(INDUCES); AKAP1(INDUCES); SPAAR(INDUCES) 28973854 1 1 13 K63-polyUb regulates these interactions, regulate postsynaptic scaffolding and synapse organization -TTK TTK Cancer Testis Antigen (CTA); EC 2.7.12.1; KINASE; Kinase, protein; Protein kinase, Other; Protein kinase, dual-specificity (non-receptor) P33981 7272 6q14.1 human S15-p 13194900 GRELTIDsIMNKVRD intracellular localization 18923149; 36395767 5 1 2 -KNSTRN TRAF4AF1 Q9Y448 90417 15q15.1 human T294-p 1876350206 VRFLEQQtLCNNQVN cell cycle regulation; carcinogenesis, induced; cell motility, induced; transcription, altered 35201967 1 0 0 -EIF2S1 eIF2-alpha RNA-binding; Translation; Translation initiation P05198 1965 14q23.3 human S52-p 447635 MILLSELsRRRIRSI S1 activity, induced; molecular association, regulation; activity, inhibited carcinogenesis, induced; carcinogenesis, inhibited; cell growth, inhibited; apoptosis, induced; transcription, induced; translation, altered; autophagy, induced; RNA splicing, induced; cell growth, induced; apoptosis, inhibited; translation, induced; cell growth, altered; translation, inhibited eIF2-beta(INDUCES); PERK(INDUCES); CELF1(INDUCES) 11432733; 12370288; 16288713; 16717090; 16952278; 17553788; 17998206; 19934253; 20660158; 25660019; 25759478; 26100016; 27409837; 28683312; 32054729; 33705388; 34244887; 34380029; 34426706; 34615996; 35035775; 35331268; 35354045; 35378132; 36226539; 36460969; 36480552; 36898579; 7641700 132 2 0 -BCHE BCHE EC 3.1.1.8; Hydrolase; Nuclear envelope; Secreted; Secreted, signal peptide P06276 590 3q26.1 human S226-p 25157201 SVTLFGEsAGAASVS COesterase enzymatic activity, inhibited 22444575 0 1 0 -RACK1 RACK1 Adaptor/scaffold; G protein; G protein, heterotrimeric; G protein, heterotrimeric beta; Motility/polarity/chemotaxis; Nuclear receptor co-regulator P63244 10399 5q35.3 human T39-p 56567301 LSASRDKtIIMWKLT WD40 molecular association, regulation autophagy, induced ATG5(INDUCES) 27325703 1 1 0 -Vav1 VAV1 GEF; GEF, Rac/Rho; Motility/polarity/chemotaxis; Oncoprotein P27870 22324 17 D|17 29.76 cM mouse Y174-p 447866 EAEGDEIyEDLMRLE activity, induced; protein conformation; activity, inhibited cytoskeletal reorganization; transcription, altered; cell growth, altered 10669745; 20141838; 34617326 22 2 0 -THOC5 FMIP Cell development/differentiation; RNA splicing; Spliceosome Q13769 8563 22q12.2 human S6-p 453433 __MSSESsKKRKPKV intracellular localization 15221008 1 0 0 -Rb1 Rb Nuclear receptor co-regulator; Oncoprotein; Transcription, coactivator/corepressor; Tumor suppressor P13405 19645 14 38.73 cM|14 D3 mouse S800-p 447980 PGGNIYIsPLKSPYK Rb_C molecular association, regulation; protein conformation; phosphorylation cell cycle regulation; carcinogenesis, induced; transcription, induced; transcription, altered; cell growth, induced; chromatin organization, altered; apoptosis, inhibited; DNA repair, inhibited; transcription, inhibited E2F1(DISRUPTS); SUV420H1(DISRUPTS); SUV420H2(DISRUPTS) 10207050; 1565466; 32086342; 33826903; 35023164; 35947949; 9671466 102 45 112 transcriptional downregulation of the E2F-1, E2F-2, dihydrofolate reductase, thymidine kinase, c-myc, proliferating-cell nuclear antigen, p107, and p21/Cip1 genes -Notch1 Notch 1 Membrane protein, integral; Motility/polarity/chemotaxis; Oncoprotein; Receptor, misc.; Transcription factor Q01705 18128 2 A3|2 18.91 cM mouse K2147-ac 18899504 KSATQGKkARKPSTK protein stabilization; ubiquitination 21499261 2 1 0 -Ksr1 KSR KINASE; Kinase, protein; Protein kinase, Ser/Thr (non-receptor); Protein kinase, TKL Q61097 16706 11 B5|11 46.74 cM mouse S392-p 449297 ARLRRTEsVPSDINN protein degradation; molecular association, regulation; intracellular localization cell cycle regulation; cell growth, altered 14-3-3 beta(INDUCES); 14-3-3 gamma(INDUCES) 11741534; 11741955; 12105213; 15371409; 28003362; 9858547 8 48 75 -Eif2ak3 PERK EC 2.7.11.1; KINASE; Kinase, protein; Membrane protein, integral; Protein kinase, Other; Protein kinase, Ser/Thr (non-receptor); Translation Q9Z2B5 13666 6|6 C1 mouse Y615-p 1256400 NKVDDCNyAIKRIRL Pkinase enzymatic activity, induced translation, altered 17998206 4 1 0 regulates translation through the phosphorylation of eIF2A at S51 -HSF1 HSF1 DNA-binding; Transcription factor Q00613 3297 8q24.3 human T323-p 4169776 GRPSSVDtLLSPTAL Vert_HS_TF transcription, inhibited 25963659 2 8 1 under non-stressed conditions, upon heat shock S to A mutant showed 60% higher luciferase activity -HDAC1 HDAC1 DEACETYLASE; Deacetylase; EC 3.5.1.98; Hydrolase; Nuclear receptor co-regulator Q13547 3065 1p35.2-p35.1 human K441-ac 4219804 SSNFKKAkRVKTEDE enzymatic activity, inhibited transcription, inhibited 16762839 1 0 0 -Crtc2 TORC2 Transcription, coactivator/corepressor Q3U182 74343 3|3 F1 mouse S307-p 454633 PSLSGGNsTTNLTHT TORC_M intracellular localization transcription, induced 20551288; 33127851 2 1 0 -HMGB1 HMGB1 DNA repair, damage; Nuclear receptor co-regulator P09429 3146 13q12.3 human S42-p 9484300 SVNFSEFsKKCSERW HMG_box_2 intracellular localization cell motility, altered 19506549; 23782844 3 0 2 increases tumor cell invasiveness -Hspa1a HSP70 Chaperone; Heat shock protein; Motility/polarity/chemotaxis Q61696 193740 17 B1|17 18.51 cM mouse R447-me 1877047300 IQVYEGErAMTRDNN HSP70 protein stabilization carcinogenesis, induced; cell growth, induced; apoptosis, inhibited RNA(INDUCES) 32699135 1 1 0 binding and stabilization of BCL2 mRNA -AQP4 AQP4 Channel, misc.; Membrane protein, integral; Membrane protein, multi-pass; Transporter; Transporter, aquaporin family P55087 361 18q11.2 human S276-p 465556 AAQQTKGsYMEVEDN intracellular localization 26013827 2 6 0 translocation to cell surface -ABCC8 ABCC8 Membrane protein, integral; Membrane protein, multi-pass; Transporter; Transporter, ABC family Q09427 hamster S1447-p 22634903 LDPEKKCsDSTLWEA ABC_tran activity, induced 12198249 1 0 0 channel closure -ETS2 Ets-2 DNA-binding; Oncoprotein; Transcription factor P15036 2114 21q22.2 human S225-p 30320501 LDSMCPAsTPSVLSS protein degradation 24218572; 26871468 2 1 0 CDK10 mediated degradation -NR3C1 GR DNA-binding; Mitochondrial; Nuclear receptor; Transcription factor P04150 2908 5q31.3 human S211-p 447968 PGKETNEsPWRSDLL GCR activity, induced; molecular association, regulation; protein stabilization; intracellular localization; protein conformation; activity, inhibited cell cycle regulation; apoptosis, induced; transcription, induced; transcription, altered; transcription, inhibited GRIP1(INDUCES) 15817653; 17440046; 19841061; 20047289; 21829454; 24024586; 25847991; 28582465; 33235235; 35409338; 36103837 51 5 0 -Tp53 p53 Activator; DNA-binding; Motility/polarity/chemotaxis; Nuclear receptor co-regulator; Transcription factor; Tumor suppressor P02340 22059 11 B3|11 42.83 cM mouse K117-ac 474514 FLQSGTAkSVMCTYS P53 cell cycle regulation; carcinogenesis, inhibited; cell growth, inhibited; apoptosis, induced; transcription, induced 25858503; 31004086; 33303641; 33789902; 35534985 44 8 0 HDAC6 ablation induces senescence p21 expression and inhibits cell growth, HDAC6 ablation inhibits HC proliferation after two-thirds partial hepatectomy (PHx); recruit p300, CBP, and TIP60 onto PD-1 promoter, p53-mediated PD-1 transcription; increase in C-terminal methylation (K370, K372 dimethylation) and K117 acetylation leads to induction of pro-apoptotic p53 target genes Bax, Puma, Noxa TrailR2 in response to IR ; senescence, ferroptosis, failed to develop early-onset tumors -Hnf4a HNF4 alpha DNA-binding; Nuclear receptor; Transcription factor P49698 15378 2 H3|2 84.32 cM mouse S262-p 63076100 CPELAEMsRVSIRIL Hormone_recep molecular association, regulation SSU72(INDUCES) 34616001 2 1 0 -FBXO46 FBX46 UBIQUITIN LIGASE; Ubiquitin conjugating system; Ubiquitin ligase Q6PJ61 23403 19q13.32 human S21-p 1261736702 PRPFGTYsQNQPRPP protein degradation 30171069 1 0 0 -KLF2 KLF2 C2H2-type zinc finger protein; DNA-binding Q9Y5W3 10365 19p13.11 human T173-p 4728135 RPPPPPDtPPLSPDG protein degradation; ubiquitination carcinogenesis, induced; cell motility, induced; cell growth, induced 33758320 2 8 21 -Ctnnd1 CTNND1 Actin-binding; Adaptor/scaffold; Cell adhesion; G protein regulator, misc.; Motility/polarity/chemotaxis P30999 12388 2 D|2 49.45 cM mouse T310-p 450457 GTARRTGtPSDPRRR molecular association, regulation cell adhesion, inhibited 26175155; 26845024 10 7 28 310A and 268A mutants showed clumping, overall phosphorylation regulates activity; decreased homophilic binding affinity of E-cadherin -Cgas cGAS EC 2.7.7.86 Q8C6L5 214763 9|9 E1 mouse K372-sm 62952702 LSFSHTEkYILNNHG Mab-21 enzymatic activity, inhibited transcription, inhibited; signaling pathway regulation DNA(DISRUPTS) 28095500 1 0 0 regulation of STING signaling pathway -COIL coilin Oxidoreductase P38432 8161 17q22 human T122-p 459728 QLEEGEEtEPDCKYS Coilin_N cell growth, inhibited 21991343 1 54 61 Cajal body formation, phosphomutant cell lines show a significant reduction in CB formation compared to wild-type after endogenous coilin knockdown -Crtc2 TORC2 Transcription, coactivator/corepressor Q3U182 74343 3|3 F1 mouse S171-gl 10902816 SALNRTSsDSALHTS TORC_M activity, induced; molecular association, regulation; intracellular localization; phosphorylation 14-3-3 beta(DISRUPTS) 18323454 1 1 0 inhibits phosphorylation of its own site -PSTPIP2 PSTPIP2 Actin-binding Q9H939 9050 18q21.1|tdb7990 human Y333-p 449699 VDDYSLLyQ______ molecular association, regulation SHIP(INDUCES) 26304991 1 1 2 -WDHD1 WDHD1 DNA-binding O75717 11169 14q22.2-q22.3 human T826-p 458395 KAAELTAtQVEEEEE molecular association, regulation; intracellular localization; protein conformation; phosphorylation; enzymatic activity, induced carcinogenesis, induced; DNA repair, induced FANCM(INDUCES); FAAP24(INDUCES); claspin(INDUCES) DNA(INDUCES) 26082189; 35867033 2 8 28 -MET Met EC 2.7.10.1; KINASE; Kinase, protein; Membrane protein, integral; Oncoprotein; Protein kinase, TK; Protein kinase, tyrosine (receptor) P08581 4233 7q31.2 human S985-p 450188 PHLDRLVsARSVSPT enzymatic activity, inhibited; intracellular localization cell motility, induced; signaling pathway regulation 23618918; 24634221; 27147579; 8294430 7 1 0 increased intracellular localization, and decreased cell membrane localization ; signaling to induce lamellipodia formation and ROS generation in lung cells; in vitro; Ser985 phosphorylation blocks Tyr1234 phosphorylation of c-Met -NADK2 NADK2 EC 2.7.1.23 Q4G0N4 133686 5p13.2 human S289-p 25746483 ESLSSRAsYYEISVD enzymatic activity, inhibited 26577408 1 0 1 -Ppfia1 liprin alpha 1 Cell adhesion; Motility/polarity/chemotaxis D3ZZ81 293645 1q42 rat T700-p 31873705 PPGSGRStPRRVPHS molecular association, regulation; intracellular localization PSD-95(DISRUPTS) 28760951 1 1 0 regulates synaptic plasticity -E2F1 E2F1 DNA-binding; Transcription factor Q01094 1869 20q11.22 human S235-p 1870773100 TTQLRLLsEDTDSQR E2F_CC-MB protein degradation; enzymatic activity, induced cell cycle regulation; cell growth, inhibited; apoptosis, induced 33110360 1 0 0 induces ?-galactosidase activity -FMR1 FMR1 Nucleolus; RNA-binding; Translation Q06787 2332 Xq27.3 human R544-me 4046000 GGRGQGGrGRGGGFK RNA splicing, altered 16922515 4 0 0 S500 phosphorylation has no affect on methylation; alternatively spliced variant of FMR1 exon 15, reduced methylation by more than 85% -Cask CASK Adaptor/scaffold; EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, CAMK; Protein kinase, Ser/Thr (non-receptor) Q62915 29647 Xq12 rat T724-p 12568401 LPAFKRKtLVLLGAH Guanylate_kin molecular association, regulation transcription, altered TBR1(INDUCES) 20067577 1 0 2 CASK-Tbr1 complex regulates expression of NMDAR2b -Arrb2 ARRB2 Adaptor/scaffold Q91YI4 216869 11 B3|11 42.99 cM mouse K18-ub 6140806 KKSSPNCkLTVYLGK molecular association, regulation mAChR M2(INDUCES); mAChR m1(INDUCES) 19055777 1 0 0 -Slc17a7 SLC17A7 Membrane protein, integral; Membrane protein, multi-pass; Transporter; Transporter, SLC family; Vesicle Q62634 116638 1q22 rat S522-p 4717549 QLAGSDEsEMEDEVE molecular association, regulation AP2A2(INDUCES) 25334008 1 1 0 -CAT Catalase Amino Acid Metabolism - tryptophan; Apoptosis; EC 1.11.1.6; Endoplasmic reticulum; Energy Metabolism - methane; Hydrolase; Mitochondrial; Oxidoreductase P04040 847 11p13 human S167-p 30259808 LFPSFIHsQKRNPQT Catalase protein conformation; enzymatic activity, induced 24211614 1 1 0 phosphorylation necessary for tetramerization -AR AR DNA-binding; Nuclear receptor; Transcription factor P10275 367 Xq12 human S516-p 452166 VSRVPYPsPTCVKSE protein degradation; ubiquitination; intracellular localization cell cycle regulation; cell growth, induced; transcription, induced; transcription, altered 18511414; 21157430; 23321516; 28638477; 29423094 10 3 0 -HSPA5 GRP78 Chaperone; Heat shock protein; KINASE P11021 3309 9q33.3 human K154-ac 13362600 AMVLTKMkETAEAYL HSP70 molecular association, regulation; phosphorylation apoptosis, induced; signaling pathway regulation PERK(DISRUPTS) 20371724 1 2 0 induces phosphorylation of elf2a and activation of eIf2a-ATF4-CHOP pathway -PKN2 PKN2 EC 2.7.11.13; KINASE; Kinase, protein; Protein kinase, AGC; Protein kinase, Ser/Thr (non-receptor) Q16513 5586 1p22.2 human T816-p 447838 GYGDRTStFCGTPEF Pkinase enzymatic activity, induced 10753910; 19723632 4 7 290 -Ep300 p300 ACETYLTRANSFERASE; Acetyltransferase; EC 2.3.1.48; Motility/polarity/chemotaxis; Nuclear receptor co-regulator; Transcription, coactivator/corepressor B2RWS6 328572 15|15 E1 mouse S2312-p 486263 RSPQPVPsPRPQSQP phosphorylation transcription, induced 21498542 2 10 1 induces NFAT phosphorylation -XRCC6 Ku70 DNA repair, damage; DNA-binding; EC 3.6.4.-; EC 4.2.99.-; Helicase; Nuclear receptor co-regulator; RNA-binding P12956 2547 22q13.2 human K282-ac 483055 NLVQKALkPPPIKLY Ku molecular association, regulation DNA repair, inhibited DNA(DISRUPTS) 17545612 1 1 0 -SMURF2 SMURF2 EC 6.3.2.-; EC 6.3.2.19; Ligase; UBIQUITIN LIGASE; Ubiquitin conjugating system; Ubiquitin ligase Q9HAU4 64750 17q23.3-q24.1 human K119-ub 1877715600 YQRLDLCkLGPNDND protein degradation; ubiquitination cell differentiation, induced 31076633 1 1 0 -HMOX1 HMOX1 Cofactor and Vitamin Metabolism - porphyrin and chlorophyll; EC 1.14.99.3; Oxidoreductase P09601 3162 22q12.3 human S188-p 2897404 LYRSRMNsLEMTPAV Heme_oxygenase molecular association, regulation; enzymatic activity, induced BVR(INDUCES); POR(INDUCES) 15581622 1 1 3 -EXOC7 EXOC7 Cytoskeletal Q9UPT5 23265 17q25.1 human S250-p 483909 SSSGVPYsPAIPNKR molecular association, regulation exocytosis, induced; cell motility, induced; cytoskeletal reorganization EXOC4(INDUCES); EXOC8(INDUCES) 22595671 1 25 6 -FLRT1 FLRT1 Cell adhesion; Membrane protein, integral; Motility/polarity/chemotaxis Q9NZU1 23769 11q13.1 human Y671-p 14150101 GGIPDIDySYT____ intracellular localization cell growth, altered 20421966 1 0 0 regulates ERK1/2 activation -GLUL GLUL Amino Acid Metabolism - alanine, aspartate and glutamate; Amino Acid Metabolism - arginine and proline; EC 4.1.1.15; EC 6.3.1.2; Energy Metabolism - nitrogen; Ligase P15104 2752 1q25.3 human K14-ac 33351284 SHLNKGIkQVYMSLP protein degradation; molecular association, regulation; ubiquitination CRBN(INDUCES) 26990986 1 3 0 -Tnfaip1 TNFAIP1 DNA replication; Ubiquitin conjugating system O70479 21927 11 B5|11 46.74 cM mouse S280-p 3195881 SRSQASPsEDEDTFE intracellular localization 33159672 2 11 0 -SREBF2 SREBP-2 DNA-binding; Membrane protein, integral; Membrane protein, multi-pass; Transcription factor Q12772 6721 22q13.2 human K464-sm 2715400 LLDDAKVkDEPDSPP molecular association, regulation transcription, inhibited HDAC3(INDUCES) 12615929; 18403372 2 0 0 -HELLS HELLS Apoptosis; EC 3.6.1.-; EC 3.6.4.-; Helicase Q9NRZ9 3070 10q23.33 human S503-p 9764950 EKETIELsPTGRPKR SNF2-rel_dom molecular association, regulation; methylation carcinogenesis, induced PRMT5(DISRUPTS) 32994405 1 20 0 downregulates methylation of HELLS at R309, promotes stem cell-like properties -DDIT3 DDIT3 Autophagy; DNA-binding; Oncoprotein; Transcription factor P35638 1649 12q13.3 human S31-p 455504 DLQEVLSsDENGGTY activity, inhibited transcription, inhibited 12876286 1 0 0 -MAP2 MAP2 Cytoskeletal; Motility/polarity/chemotaxis P11137 4133 2q34 human S1679-p 456808 NVKSKIGsTDNIKYQ Tubulin-binding molecular association, regulation; intracellular localization cytoskeletal reorganization TUBA1A(INDUCES); ACTB(INDUCES) 11029056 2 7 1 -RBL2 Rb-like 2 Transcription, coactivator/corepressor; Tumor suppressor Q08999 5934 16q12.2 human S639-p 449726 DEICIAGsPLTPRRV molecular association, regulation cell cycle regulation E2F4(DISRUPTS) 11157749; 12006580 4 24 31 -MAD1L1 MAD1L1 Cell cycle regulation; Cytoskeletal Q9Y6D9 8379 7p22.3 human Y634-p 1019903 QEFRKACyTLTGYQI MAD cell cycle regulation 29162720 1 0 0 -KHSRP KHSRP RNA-binding Q92945 8570 19p13.3 human S670-p 482098 GPGAPPGsQPDYSAA DUF1897 activity, induced; molecular association, regulation 21329876 1 1 2 binds to and functions in pri-miRNA processing -P2RY1 P2RY1 GPCR, family 1; Membrane protein, integral; Membrane protein, multi-pass; Receptor, GPCR P47900 5028 3q25.2 human S352-p 1983719 RSEANLQsKSEDMTL receptor internalization, altered 19741005; 21108629 2 2 0 -Klf5 KLF5 C2H2-type zinc finger protein; DNA-binding; Transcription factor Q9Z0Z7 12224 14|14 E2.2 mouse K151-sm 4645802 RPCVTQIkTEPVTIF intracellular localization carcinogenesis, induced; cell growth, induced 18782761 2 0 0 -Syt4 SYT4 Calcium-binding; Membrane protein, integral; Vesicle P50232 64440 18p12 rat S135-p 4706863 ETEKEAVsPESLKSS molecular association, regulation neural plasticity KIF1A(DISRUPTS) 29166604 2 5 0 reduces vesicle mobility after synapse formation; decreased mobility of S135E vesicles is due to decreased binding of phosphorylated Syt4 to Kif1A; actin is specifcally involved in a Syt4 S135 phosphorylation-dependent mechanism of vesicle capture at synapses,increased neuronal activity increases p-JNK at synapses, which captures Syt4 vesicles -Smpd3 SMPD3 EC 3.1.4.12; Lipid Metabolism - sphingolipid; Membrane protein, integral; Phospholipase Q9JJY3 58994 8|8 D3 mouse S289-p 4780074 QRDGDSGsLGSPSAS protein stabilization; enzymatic activity, induced 22074919 1 12 2 -POLB POLB DNA repair, damage; DNA replication; EC 2.7.7.7; Lyase; Transferase P06746 5423 8p11.21 human K72-ac 460603 VGTKIAEkIDEFLAT HHH_8 DNA repair, inhibited 12453427 1 3 0 -ITCH ITCH EC 6.3.2.-; EC 6.3.2.19; Ligase; UBIQUITIN LIGASE; Ubiquitin conjugating system; Ubiquitin ligase Q96J02 83737 20q11.22 human Y420-p 454077 QFNQRFIyGNQDLFA molecular association, regulation JunB(DISRUPTS) 16387660 1 2 108 -RBBP8 CtIP EC 3.1.-.-; Transcription, coactivator/corepressor Q99708 5932 18q11.2 human T859-p 27427901 WEVGFPStQTCMERG SAE2 molecular association, regulation DNA repair, induced; cell growth, induced DNA(INDUCES) 23273981; 31097467 6 1 0 -CAMKK2 CAMKK2 Autophagy; EC 2.7.11.17; KINASE; Kinase, protein; Protein kinase, Other; Protein kinase, Ser/Thr (non-receptor) Q96RR4 10645 12q24.31 human S495-p 469882 KTMIRKRsFGNPFEG molecular association, regulation; enzymatic activity, inhibited Calmodulin(DISRUPTS) 32913128 3 42 35 -Sos1 SOS1 Adaptor/scaffold; GEF; GEF, Ras; Motility/polarity/chemotaxis Q62245 20662 17 E3|17 50.67 cM mouse Y1182-p 34550593 SKAYSPRySISDRTS cell motility, induced; cytoskeletal reorganization 28819285 1 1 3 SOS1 RAC1 GEF activity -TARDBP TDP-43 RNA-binding Q13148 23435 1p36.22 human S379-p 3084615 NSYSGSNsGAAIGWG molecular association, regulation; intracellular localization; phosphorylation RNA splicing, inhibited; RNA stability, inhibited TDP-43(DISRUPTS) 34107054; 35112738 6 2 0 primes phosphorylation at other sites; promotes cytoplasmic aggregation -IRS2 IRS2 Adaptor/scaffold; Motility/polarity/chemotaxis Q9Y4H2 8660 13q34 human Y978-p 463371 QRSPLSDyMNLDFSS molecular association, regulation PIK3C2A(INDUCES) 30459283 1 6 21 -ARRB2 ARRB2 iso2 Adaptor/scaffold P32120-2 281638 cow K295-sm 25350103 LALDGKLkHEDTNLA Arrestin_C molecular association, regulation AP-2 beta(INDUCES) 21118812 2 0 0 GPCR endocytosis induced -KLF5 KLF5 C2H2-type zinc finger protein; DNA-binding; Transcription factor Q13887 688 13q22.1 human R57-m2 1881305500 ELKHAHHrPQAQPAP protein stabilization cell growth, induced 33972717 1 0 0 cell growth and stemness -SMAD4 SMAD4 DNA-binding; Nuclear receptor co-regulator; Transcription, coactivator/corepressor Q13485 4089 18q21.2 human Y301-p 1881244702 MPPHPGHyWPVHNEL molecular association, regulation cell cycle regulation; carcinogenesis, induced; cell growth, induced; transcription, inhibited p300(DISRUPTS); CBP(DISRUPTS); H3(DISRUPTS) 36959211 1 1 0 binding to p300 promotes p300 binding to DNA -NCL NCL DNA-binding; Helicase; Nuclear receptor co-regulator; Nucleolus; RNA-binding P19338 4691 2q37.1 human S28-p 452262 PKEVEEDsEDEEMSE intracellular localization cell cycle regulation; cell growth, induced 25313645 2 45 9 -Kcnc3 Kv3.3 Membrane protein, integral; Membrane protein, multi-pass Q63959 16504 7 B3|7 28.85 cM mouse S3-p 2840509 _____MLsSVCVWSF Potassium_chann activity, inhibited 18539595 1 0 0 -Diaph3 Diaphanous-3 Motility/polarity/chemotaxis Q9Z207 56419 14|14 E1 mouse S1070-p 14572460 KLKDIRQsLSPMSQR activity, induced; molecular association, regulation; intracellular localization; protein conformation transcription, induced; cytoskeletal reorganization Diaphanous-3(DISRUPTS) 21699497 1 14 0 -Top2b TOP2B Cell development/differentiation; DNA-binding; EC 5.99.1.3; Motility/polarity/chemotaxis; Nucleolus; Topoisomerase Q64511 21974 14|14 A2 mouse S1509-p 452750 KIVETINsDSDSEFG DTHCT transcription, inhibited 36206766 1 81 11 -XRCC1 XRCC1 DNA repair, damage P18887 7515 19q13.31 human S421-p 3181474 EASHSGGsGDEAPKL molecular association, regulation PARP1(DISRUPTS) 25477519 1 4 0 -RBM10 RBM10 C2H2-type zinc finger protein; RNA splicing; RNA-binding P98175 8241 Xp11.3 human S89-p 4033099 RRRRHRHsPTGPPGF molecular association, regulation carcinogenesis, induced; RNA splicing, altered; cell growth, induced; RNA stability, induced RNA(INDUCES) 37334492 1 47 31 -NF2 Merlin Cytoskeletal; Motility/polarity/chemotaxis; Tumor suppressor P35240 4771 22q12.2 human K159-ub 21178798 DYDPSVHkRGFLAQE FERM_M molecular association, regulation; intracellular localization LATS1(DISRUPTS) 30918126 1 4 0 K63 kinked -VCL Vinculin Cell adhesion; Cytoskeletal; Motility/polarity/chemotaxis P12003 396422 chicken Y100-p 454004 QMLQADPySVPARDY Vinculin protein conformation cell adhesion, altered 15229287 4 3 53 phosphorylation of this site positively regulates cell spreading -ERRFI1 MIG-6 Inhibitor; Tumor suppressor Q9UJM3 54206 1p36.23 human S256-p 17547330 SHSGPAGsFNKPAIR activity, inhibited 29196224 1 3 0 ine?cient ubiquitination and increased stability of EGFR -MYC Myc DNA-binding; Nucleolus; Oncoprotein; Transcription factor P01106 4609 8q24.21 human K172-sm 40724410 ASYQAARkDSGSPNP Myc_N protein degradation; ubiquitination transcription, inhibited 25895136 1 1 0 -MARCKS MARCKS Actin-binding; Motility/polarity/chemotaxis P12624 613548 cow S162-p 447787 KRFSFKKsFKLSGFS MARCKS exocytosis, induced 22013076 24 30 7 Calcium mobilization, degranulation induced and dissociation of MARCK5 from plasma membrane. -Gabbr1 GABBR1 GPCR, family 3; Membrane protein, integral; Membrane protein, multi-pass; Receptor, GPCR Q9Z0U4 81657 20p12 rat K698-ub 59175200 FTKKEEKkEWRKTLE 7tm_3 receptor recycling, inhibited; protein degradation; intracellular localization 27573246 1 0 0 -NOL3 ARC Apoptosis; Nucleolus O60936 8996 16q22.1 human T149-p 448618 SEAVQSGtPEEPEPE intracellular localization apoptosis, inhibited 26172393 5 6 0 inhibits DOX-induced apoptosis -Ngfr NGFR Membrane protein, integral; Receptor, misc. P07174 24596 10q26 rat Y337-p 454435 LKGDGNLySSLPLTK protein degradation; molecular association, regulation CBL(INDUCES) 15337528 1 1 3 -MAPT Tau iso8 ACETYLTRANSFERASE; Acetyltransferase; Cytoskeletal P10636-8 4137 17q21.31 human S352-p 487459 DFKDRVQsKIGSLDN Tubulin-binding molecular association, regulation 21204788 2 1 0 in vitro microtubule binding -TERF2IP TERF2IP DNA replication Q9NYB0 54386 16q23.1 human S205-p 471278 GDAPVSPsSQKLKRK intracellular localization apoptosis, induced; transcription, induced; transcription, inhibited; signaling pathway regulation 31045573; 31476350 2 6 2 important for NFkB activation by TNF-alpha; endothelial cell senescence and activation; promotes the nuclear export of the TERF2IP-TRF2 complex -ECE1 ECE1 iso3 Cell surface; EC 3.4.24.71; Membrane protein, integral; Protease; Vesicle P42892-3 1889 1p36.12 human S18-p 3053605 DEEDLVDsLSEGDAY protein stabilization; intracellular localization; phosphorylation cell cycle regulation; carcinogenesis, induced; cell growth, induced; cell motility, induced; apoptosis, inhibited; transcription, induced 26543229; 32850305 3 12 1 induces FAK phosphorylation; colon cancer cell invasion. -FH fumarase Carbohydrate Metabolism - citrate (TCA) cycle; EC 4.2.1.2; Lyase; Mitochondrial; Tumor suppressor P07954 2271 1q43 human S75-p 116533304 YGAQTVRsTMNFKIG Lyase_1 molecular association, regulation cell growth, induced; transcription, induced ATF-2(INDUCES) 28628081 1 1 0 -Rps6kb1 p70S6K EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, AGC; Protein kinase, Ser/Thr (non-receptor); Translation Q8BSK8 72508 11|11 C mouse S434-p 448356 SFEPKIRsPRRFIGS molecular association, regulation DEDD(INDUCES) 19106089 28 1 0 Association with DEDD in vitro and in vivo prevents inhibitory phosphorylation by Cdk1 at S434, T444, and S447. -MEF2C MEF2C DNA-binding; Transcription factor Q06413 4208 5q14.3 human K252-ac 12674410 NLGMNNRkPDLRVLI molecular association, regulation cell differentiation, induced; transcription, induced MRF(INDUCES) DNA(INDUCES) 15831463 1 0 0 -Acadl ACADL EC 1.3.8.8; Lipid Metabolism - fatty acid; Mitochondrial; Oxidoreductase P51174 11363 1 C3|1 33.64 cM mouse K42-ac 1194111 RLETPSAkKLTDVGI enzymatic activity, inhibited 20203611 2 3 13 regulation of fatty-acid oxidation -MORC2 MORC2 DNA-binding Q9Y6X9 22880 22q12.2 human K767-ac 11324199 KRGRFVVkEEKKDSN molecular association, regulation cell cycle regulation; DNA repair, induced; transcription, inhibited H3(INDUCES) 32112098 1 2 0 Acetylated MORC2 at K767 binds to H3T11P, downregulation of H3T11P and transcriptional repression of CDK1 and Cyclin B1 -Trim28 TIF1B EC 6.3.2.-; KINASE; Kinase, protein; Ligase; Nuclear receptor co-regulator; Protein kinase, atypical; SUMO LIGASE; SUMO ligase; Transcription, coactivator/corepressor; UBIQUITIN LIGASE; Ubiquitin conjugating system; Ubiquitin ligase Q62318 21849 7|7 A1 mouse K554-sm 2798310 LPGMAIVkEEETEAA transcription, inhibited 17298944 5 2 0 -Cebpb C/EBP-beta DNA-binding; Motility/polarity/chemotaxis; Transcription factor P28033 12608 2 H3|2 87.58 cM mouse T179-p 455887 GSSGSLStSSSSSPP activity, induced; molecular association, regulation; protein conformation cell cycle regulation; cell differentiation, altered; cell differentiation, induced; transcription, induced; transcription, inhibited; signaling pathway regulation; transcription, altered C/EBP-beta(INDUCES) DNA(INDUCES) 15985551; 17264204; 17601773; 19244213; 19478079 6 3 0 -Septin4 SEPT4 Apoptosis; Cell development/differentiation; Cytoskeletal; Hydrolase P28661 18952 11|11 C mouse S100-p 4705460 FSAPAPLsPSSRPRS cell motility, altered 26590424 1 2 1 -DACT1 DACT1 Adaptor/scaffold Q9NYF0 51339 14q23.1 human S827-p 18159800 KKILRFRsGSLKLMT Dapper molecular association, regulation carcinogenesis, altered; cell growth, altered 14-3-3 beta(INDUCES) 21262972 1 1 0 ; modulates Wnt signaling -FOXO3 FOXO3A Autophagy; DNA-binding; Oncoprotein; Transcription factor O43524 2309 6q21 human S574-p 20799900 SAKHQQQsPVSQSMQ intracellular localization apoptosis, induced; transcription, induced; transcription, inhibited 23857333; 26470730; 27669435 5 2 0 -EGFR EGFR EC 2.7.10.1; KINASE; Kinase, protein; Membrane protein, integral; Oncoprotein; Protein kinase, TK; Protein kinase, tyrosine (receptor) P00533 1956 7p11.2 human Y1138-p 457950 TAVGNPEyLNTVQPT molecular association, regulation GRB2(INDUCES); SHC1(INDUCES) 16729043 1 12 58 -PDGFRA PDGFRA EC 2.7.10.1; KINASE; Kinase, protein; Membrane protein, integral; Oncoprotein; Protein kinase, TK; Protein kinase, tyrosine (receptor) P16234 5156 4q12 human Y1018-p 448647 RLSADSGyIIPLPDI molecular association, regulation PLCG1(INDUCES) 11818394; 7535778 5 11 93 -AKAP8 AKAP8 Adaptor/scaffold; Cell cycle regulation; Mitochondrial; RNA-binding O43823 10270 19p13.12 human Y53-p 40420004 TTGATYSyGPASWEA molecular association, regulation 25770215 1 0 0 Phenylalanine mutants inhibited dissociation from nuclear structures; structural chromatin changes -Slc9a3 NHE3 Membrane protein, integral; Membrane protein, multi-pass; Transporter; Transporter, SLC family P26433 24784 1p11 rat S552-p 450899 AEGERRGsLAFIRSP molecular association, regulation; intracellular localization; activity, inhibited SYT1(INDUCES) 11937500; 15687252; 19926819; 20630932; 21593184; 23235337; 24666699; 25656367; 33476711; 33868007; 9933588 27 5 4 -Cebpa C/EBP-alpha DNA-binding; Transcription factor P53566 12606 7 B2|7 21.02 cM mouse S193-p 1868113505 PPPHPHAsPAHLAAP activity, induced; protein degradation; molecular association, regulation; ubiquitination; intracellular localization cell cycle regulation; carcinogenesis, inhibited; carcinogenesis, altered; apoptosis, induced; cell growth, inhibited; transcription, induced; transcription, altered; cell differentiation, induced; cell growth, induced; translation, induced; transcription, inhibited; cell growth, altered CDK2(INDUCES); HDAC1(DISRUPTS); SMARCA2(INDUCES); E2F4(INDUCES); HDAC1(INDUCES); BRMS1L(INDUCES); CDK4(INDUCES); Rb(DISRUPTS); PSMD10(INDUCES); HP1 alpha(INDUCES); p300(INDUCES); C/EBP-beta(INDUCES) DNA(INDUCES) 15107404; 15684384; 16537903; 17290224; 20516642; 20698834; 24273171; 26487680; 27373160; 29159818; 30089269; 34245919 15 0 0 -Gja1 GJA1 Channel, misc.; Membrane protein, integral; Membrane protein, multi-pass; Motility/polarity/chemotaxis P23242 14609 10 B4|10 28.64 cM mouse S282-p 448854 TAPLSPMsPPGYKLV activity, induced; receptor internalization, induced; protein degradation; ubiquitination; intracellular localization cell growth, induced; apoptosis, inhibited 22729691; 25952543; 29959233; 30770876; 30872361 42 7 1 cardiomyocyte homeostasis -Plcb3 PLCB3 Carbohydrate Metabolism - inositol phosphate; EC 3.1.4.11; Phospholipase P51432 18797 19 A|19 5.1 cM mouse S537-p 448450 TSLEPQKsLGEESLS phosphorylation cell motility, induced; signaling pathway regulation 21868363 6 36 7 FAK-Y397 phosphorylation, Tpl2-induced cell migration pathway -YAP1 YAP1 Oncoprotein; Transcription, coactivator/corepressor P46937 10413 11q22.1 human K204-ub 1883364800 TTWQDPRkAMLSQMN protein degradation; ubiquitination carcinogenesis, inhibited; apoptosis, induced; cell motility, inhibited 36280829 1 0 0 -Cux1 CUTL1 DNA-binding; Membrane protein, integral; Transcription factor P53564 13047 5 G2|5 75.96 cM mouse S972-p 457410 VLGLSQGsVSDMLSR CUT molecular association, regulation transcription, altered DNA(DISRUPTS) 9446557 1 0 0 -F2RL1 F2RL1 GPCR, family 1; Membrane protein, integral; Membrane protein, multi-pass; Receptor, GPCR P55085 2150 5q13.3 human T392-p 1870757304 SYSSSSTtVKTSY__ receptor desensitization, induced; molecular association, regulation; phosphorylation signaling pathway regulation ARRB1(INDUCES); ARRB2(INDUCES) 33073187 1 0 0 inhibits ERK phosphorylation and signaling; regulates calcium signaling -CARD11 CARD11 Adaptor/scaffold Q9BXL7 84433 7p22.2 human S893-p 1876333500 SPRLSRAsFLFGQLL molecular association, regulation; enzymatic activity, inhibited; phosphorylation transcription, inhibited; signaling pathway regulation Bcl-10(DISRUPTS); TRAF2(DISRUPTS); cIAP1(DISRUPTS); MALT1(DISRUPTS) 35230873 1 1 0 inhibits JNK phosphorylation and IKB alpha phosphorylation and degradation, inhibits MALT1 activity, thus inhibiting TCR signaling -Fyn Fyn EC 2.7.10.2; KINASE; Kinase, protein; Oncoprotein; Protein kinase, TK; Protein kinase, tyrosine (non-receptor) P39688 14360 10 B1|10 20.51 cM mouse Y28-p 447879 SLNQSSGyRYGTDPT enzymatic activity, inhibited 8144681 2 4 11 Y527F mutation converted Fyn into a dominant oncoprotein, capable of full transformation of rodent fibroblasts. -Sgo1 SGO1 Cell cycle regulation Q9CXH7 72415 17|17 C mouse T146-p 2535905 QQIAVEEtDCPYQTT intracellular localization 18331714 1 0 0 S73A and T146A mutants do not localize to the spindle pole region -MYO3A MYO3A Actin-binding; EC 2.7.11.1; KINASE; Kinase, protein; Motor; Protein kinase, STE; Protein kinase, Ser/Thr (non-receptor) Q8NEV4 53904 10p12.1 human T184-p 29674700 STRHRRNtSVGTPFW Pkinase intracellular localization; enzymatic activity, induced cytoskeletal reorganization 24214986; 25402663 3 3 0 T184A enhances filopodia elongation whereas T184E reduces filopodia elongation. -TWIST1 TWIST1 Cell development/differentiation; DNA-binding; Inhibitor; Transcription regulation Q15672 7291 7p21.1 human T121-p 38546302 NVRERQRtQSLNEAF HLH protein degradation; molecular association, regulation TWIST1(INDUCES) 26759241; 32179550 4 0 0 induces EMT; bimolecular fluorescence complementation (BiFC) assay -YAP1 YAP1 Oncoprotein; Transcription, coactivator/corepressor P46937 10413 11q22.1 human Y444-p 54390605 QQNRFPDyLEAIPGT protein degradation; molecular association, regulation; ubiquitination carcinogenesis, inhibited SIAH1(INDUCES) 35723276 2 0 0 -MEOX2 MEOX2 DNA-binding P50222 4223 7p21.2 human S155-p 36702792 DYGRQALsPAEAEKR intracellular localization; phosphorylation carcinogenesis, induced; cell growth, induced; transcription, induced 35468210 1 6 0 -KIR2DL1 KIR2DL1 Membrane protein, integral; Receptor, misc. P43626 3802 19q13.42 human Y332-p 18500400 PPTDIIVyTELPNAE molecular association, regulation signaling pathway regulation supervillin(INDUCES) 21070852 1 0 0 supervillin is required for KIR2DL1-mediated inhibition of Vav1 and Erk phosphorylation -APP APP Apoptosis; Cell surface; Membrane protein, integral; Receptor, misc.; Transcription factor P05067 351 21q21.3 human C186-pa 62489908 FRGVEFVcCPLAEES APP_Cu_bd molecular association, regulation APP(INDUCES) 27875558 1 0 0 palAPP dimerizes ~4.5 times more efficiently -Dync1i2 DYNC1I2 iso3 Microtubule-binding; Motility/polarity/chemotaxis; Motor Q62871-3 116659 rat S84-p 4033130 PPPMSPSsKSVSTPS molecular association, regulation; protein conformation dynactin 1(DISRUPTS) 28162951 3 11 2 -Pdgfrb PDGFRB EC 2.7.10.1; KINASE; Kinase, protein; Membrane protein, integral; Oncoprotein; Protein kinase, TK; Protein kinase, tyrosine (receptor) Q05030 rat Y578-p 447521 VSSDGHEyIYVDPVQ enzymatic activity, induced cell cycle regulation; cell growth, induced; signaling pathway regulation 23776396 11 1 0 downstream signaling pathway phosphorylation of STAT3, ERK1/2, Akt, and PLCG1 was determined in PDGF-stimulated VSMCs -Axin1 axin 1 Adaptor/scaffold; Tumor suppressor O35625 12005 17 A3.3|17 13.07 cM mouse K858-sm 2407408 FEEKIIGkVEKVD__ DIX protein stabilization; enzymatic activity, induced 12223491; 18632848 2 0 0 induces JNK activity; prevents ubiquitination -CERT1 COL4A3BP EC 2.7.11.9; KINASE; Kinase, protein; Lipid-binding; Protein kinase, Ser/Thr (non-receptor); Protein kinase, atypical Q9Y5P4 10087 5q13.3 human T146-p 125104503 GASGYSAtSTSSFKK molecular association, regulation; activity, inhibited 28652409 0 1 0 reduced PtdIns(4)P binding affinity as well as low ceramide transfer activity, E494R/N495K/P535R/E537K mutations, recovery of both PtdIns(4)P binding and ceramide transfer activity. -Psma1 PSMA1 EC 3.4.25.1; Protease; Proteasome complex Q9R1P4 26440 7 F1|7 59.32 cM mouse K30-ac 31910303 EYAMEAVkQGSATVG Proteasome protein degradation 24037710 0 1 0 -DAPK1 DAPK1 Apoptosis; Autophagy; EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, CAMK; Protein kinase, Ser/Thr (non-receptor) P53355 1612 9q21.33 human Y490-p 487483 HCAAWHGyYSVAKAL Ank_2 enzymatic activity, inhibited; protein conformation carcinogenesis, induced; cell motility, induced; cell adhesion, induced; apoptosis, inhibited 17803936 1 0 0 -Rorc RORC iso2 DNA-binding; Nuclear receptor; Transcription factor P51450-2 19885 3|3 F2.1 mouse K446-ub 56836805 LLAKLPPkGKLRSLC Hormone_recep molecular association, regulation cell differentiation, inhibited; transcription, inhibited SRC-1(DISRUPTS) 27430721 1 1 0 -KCNH2 Kv11.1 Channel, potassium; Membrane protein, integral; Membrane protein, multi-pass; Motility/polarity/chemotaxis Q12809 3757 7q36.1 human S1137-p 4696829 EGPTRRLsLPGQLGA activity, induced; molecular association, regulation; activity, inhibited signaling pathway regulation 14-3-3 eta(INDUCES) 10488078; 10837251; 11953308 3 14 6 -Drgx DRGX DNA-binding Q8BYH0 107751 14|14 B mouse S119-p 18321103 PPVRNINsPPPGDQT activity, induced; protein conformation transcription, altered; transcription, inhibited 24564673; 28049756 2 3 0 -ARHGAP24 ARHGAP24 GAP; GAP, Rac/Rho; Motility/polarity/chemotaxis Q8N264 83478 4q21.23-q21.3 human S391-p 484901 RSSMNNGsPTALSGS activity, induced cytoskeletal reorganization 16862148 1 12 0 membrane blebbing -VCL Vinculin Cell adhesion; Cytoskeletal; Motility/polarity/chemotaxis P12003 396422 chicken Y822-p 450873 KSFLDSGyRILGAVA Vinculin molecular association, regulation; phosphorylation cell growth, inhibited; cell motility, inhibited; cell adhesion, inhibited PXN(DISRUPTS); talin 1(DISRUPTS) 37248996 5 45 1609 inhibits MLC phosphorylation -IRF4 IRF4 DNA-binding; Oncoprotein; Transcription factor Q15306 3662 6p25.3 human Y122-p 473657 QLDISDPyKVYRIVP IRF activity, induced transcription, induced 23804646 2 1 3 -LEF1 LEF-1 DNA-binding; Transcription factor Q9UJU2 51176 4q25 human S166-p 11499000 TYSDEHFsPGSHPSH CTNNB1_binding activity, induced; molecular association, regulation transcription, induced; signaling pathway regulation; transcription, inhibited HDAC1(DISRUPTS) 12556497; 22373574 2 0 1 Wnt/beta-catenin signalling pathway -ZAP70 ZAP70 EC 2.7.10.2; KINASE; Kinase, protein; Protein kinase, TK; Protein kinase, tyrosine (non-receptor) P43403 7535 2q11.2 human Y315-p 448867 MPMDTSVyESPYSDP activity, induced; molecular association, regulation; protein conformation; enzymatic activity, induced; phosphorylation cell differentiation, altered; cell adhesion, altered; signaling pathway regulation CD3G(DISRUPTS); CRK(INDUCES); VAV1(INDUCES) 11514605; 15100278; 16339550; 26237552; 30992398 12 4 265 -MDM2 MDM2 EC 6.3.2.-; EC 6.3.2.19; Inhibitor; Ligase; NEDDYLATION LIGASE; Neddylation Ligase; Nucleolus; Oncoprotein; UBIQUITIN LIGASE; Ubiquitin conjugating system; Ubiquitin ligase Q00987 4193 12q15 human T351-p 17342607 KAKLENStQAEEGFD intracellular localization 27264869 2 1 0 phosphorylation inhibits MDM2 recruitment to chromatin -Ppp2r1a PPP2R1A Motility/polarity/chemotaxis; PHOSPHATASE; Protein phosphatase, regulatory subunit Q5XI34 117281 1q12 rat S303-p 31006104 AEVRAAAsHKVKEFC HEAT molecular association, regulation; protein conformation PPP2CA(DISRUPTS) 24465463 1 1 0 defect in holoenzyme assembly -GABARAPL2 GABARAPL2 Adaptor/scaffold; Autophagy; Microtubule-binding; Ubiquitin-like modifier; Vesicle P60520 11345 16q23.1 human S87-p 1869546303 VDKTVPQsSLTMGQL ATG8 molecular association, regulation apoptosis, induced ATG4B(DISRUPTS) 31709703 1 1 0 ; including ATG4A, ATG4C, ATG4D -DCBLD2 DCBLD2 Cell adhesion; Membrane protein, integral Q96PD2 131566 3q12.1|3 human Y565-p 458665 KKKTEGTyDLPYWDR molecular association, regulation CRKL(INDUCES) 23770091 2 11 52 -WASF2 WAVE2 Actin-binding; Motility/polarity/chemotaxis Q9Y6W5 10163 1p36.11 human S343-p 18715501 PPPVGFGsPGTPPPP molecular association, regulation cell motility, altered; cytoskeletal reorganization 21419341 1 0 0 regulates WRC (WAVE2 regulatory complex) interaction with Arp2/3 and lamellipodial protrusion -TP53BP1 53BP1 DNA repair, damage; Transcription, coactivator/corepressor Q12888 7158 15q15.3 human S625-p 481851 DLTCDSGsQAVPSPA molecular association, regulation DNA repair, induced RIF1(INDUCES) 31390554 1 1 0 regulates Rif1 localization -CDC73 CDC73 Cell cycle regulation; Tumor suppressor Q6P1J9 79577 1q31.2 human Y315-p 15402684 KIDTMGTyHGMTLKS molecular association, regulation; protein conformation transcription, inhibited; signaling pathway regulation CTNNB1(DISRUPTS) 21726809 1 1 1 inhibits Wnt signaling pathway -DLC1 DLC1 GAP; GAP, Rac/Rho; Tumor suppressor Q96QB1 10395 8p22 human S1244-p 17538201 NTLKRENsSPRVMQR activity, inhibited cell growth, altered 21087603 1 2 0 -PHOX2A PHOX2A DNA-binding; Transcription factor O14813 401 11q13.4 human S153-p 9400302 RKQERAAsAKGAAGA molecular association, regulation; activity, inhibited transcription, inhibited DNA(DISRUPTS) 19564421 1 1 1 inhibits neuronal differentiation; dominant-negative effect on PHOX2A activity -MDC1 MDC1 Cell cycle regulation Q14676 9656 6p21.33 human S402-p 3196337 QASMVINsDTDDEEE molecular association, regulation cell cycle regulation NBS1(INDUCES) 18678890 1 27 8 MDC1-NBS1 interaction regulates intra-S-phase checkpoint activation -Dyrk1a DYRK1A EC 2.7.12.2; KINASE; Kinase, protein; Protein kinase, CMGC; Protein kinase, dual-specificity (non-receptor) Q63470 25255 11q11 rat Y319-p 457973 CQLGQRIyQYIQSRF Pkinase enzymatic activity, induced 8631952 1 15 177 -SHC1 SHC1 iso3 Adaptor/scaffold; Apoptosis; Mitochondrial; Motility/polarity/chemotaxis P29353-3 6464 1q21.3 human Y272-p 448511 ELFDDPSyVNVQNLD phosphorylation 9566877 42 91 1971 Either FAK Y925 or Shc1 Y317 need to be phosphorylated after fibronectin to bind Grb2 to effficiently activate ERKs. -NFE2L2 NRF2 DNA-binding; Transcription factor Q16236 4780 2q31.2 human S351-p 18258503 SGISLNTsPSVASPE protein degradation; molecular association, regulation BTRC(DISRUPTS) 22751928; 32295843 3 1 0 -Mavs MAVS Adaptor/scaffold; Membrane protein, integral Q8VCF0 228607 2|2 F1 mouse K7-sc 33344549 _MTFAEDkTYKYIRD CARD_2 activity, induced 32301534 1 2 0 cellular antiviral response -Prkaca PKACA EC 2.7.11.11; KINASE; Kinase, protein; Protein kinase, AGC; Protein kinase, Ser/Thr (non-receptor) P05132 18747 8|8 C2 mouse T196-p 454125 AKRVKGRtWTLCGTP Pkinase phosphorylation cell motility, induced; cytoskeletal reorganization; signaling pathway regulation 31387938 1 26 77 induces activity towards p38 thereby increasing its, regulates PKA signaling -ATF4 ATF-4 DNA-binding; Transcription factor P18848 468 22q13.1 human S215-p 27833501 IKEEDTPsDNDSGIC protein degradation transcription, induced; signaling pathway regulation 23123191 2 1 0 ER-stress signaling pathway -Mapkapk2 MAPKAPK2 EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, CAMK; Protein kinase, Ser/Thr (non-receptor) P49138 17164 1|1 E4 mouse T208-p 448269 TSHNSLTtPCYTPYY Pkinase enzymatic activity, induced 7592979 14 3 42 -NRIP1 RIP140 Nuclear receptor co-regulator; Transcription, coactivator/corepressor P48552 8204 21q11.2-q21.1 human R649-m1 2363401 SMSVEEQrPSKQLLT NRIP1_repr_2 molecular association, regulation; intracellular localization transcription, induced Exportin-1(INDUCES) DNA(DISRUPTS) 17053781 2 2 0 -PTOV1 PTOV1 Q86YD1 53635 19q13.33 human S53-p 4767655 PPRIRARsAPPMEGA protein stabilization; molecular association, regulation; intracellular localization 14-3-3 zeta(INDUCES); HUWE1(DISRUPTS) 34654719 1 24 11 -NPR2 ANPB EC 4.6.1.2; Guanylyl cyclase; KINASE; Kinase, protein; Lyase; Membrane protein, integral; Nucleotide Metabolism - purine; Protein kinase, RGC; Protein kinase, dual-specificity (receptor); Receptor, misc. P20594 4882 9p13.3 human Y808-p 27930810 LLLRMEQyANNLEKL enzymatic activity, altered 23586811 1 0 0 -GRK2 GRK2 EC 2.7.11.15; KINASE; Kinase, protein; Protein kinase, AGC; Protein kinase, Ser/Thr (non-receptor) P21146 282682 cow Y92-p 456873 FYEEIKKyEKLETEE RGS enzymatic activity, induced 18463167 5 0 0 -Rbl2 Rb-like 2 Transcription, coactivator/corepressor; Tumor suppressor Q64700 19651 8 C4|8 44.25 cM mouse S1076-p 449741 IFYYFSNsPSKRLRE transcription, induced 35385527 5 10 0 -YAP1 YAP1 iso2 Oncoprotein; Transcription, coactivator/corepressor P46937-2 10413 11q22.1 human S351-p 471290 GTQNPVSsPGMSQEL apoptosis, inhibited; transcription, induced 22308035 8 29 12 YAP phosphorylation is required for anti-apoptotic activity of YAP in cells which are deficient in p73 alpha/beta expression. -Cebpa C/EBP-alpha DNA-binding; Transcription factor P53566 12606 7 B2|7 21.02 cM mouse T222-p 449824 HLQPGHPtPPPTPVP transcription, induced; transcription, inhibited 10567568; 17290224 8 0 0 -Wnk4 WNK4 EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, Other; Protein kinase, Ser/Thr (non-receptor) Q80UE6 69847 11|11 D mouse S332-p 456207 KRASFAKsVIGTPEF Pkinase phosphorylation; enzymatic activity, induced 28096417; 29921588; 34289367 5 11 3 -KIF20A KIF20A Microtubule-binding; Motor O95235 10112 5q31.2 human S867-p 459835 CQSSTDCsPYARILR molecular association, regulation; intracellular localization; protein conformation cell cycle regulation AurB(DISRUPTS); INCENP(DISRUPTS) 24656812 1 12 17 favours solubility, inhibits microtubule binding -MYH7 MYH7 Motility/polarity/chemotaxis; Motor P12883 4625 14q11.2 human T215-p 17551501 DQSPGKGtLEDQIIQ Myosin_head protein conformation 35502901 0 3 0 -PRKAA2 AMPKA2 Autophagy; EC 2.7.11.1; EC 2.7.11.27; EC 2.7.11.31; KINASE; Kinase, protein; Protein kinase, CAMK; Protein kinase, Ser/Thr (non-receptor) P54646 5563 1p32.2 human S491-p 450432 STPQRSCsAAGLHRP AdenylateSensor cell growth, induced; autophagy, altered 27390127; 35595099 13 12 2 -ADRB2 ADRB2 GPCR, family 1; Membrane protein, integral; Membrane protein, multi-pass; Receptor, GPCR P07550 154 5q32 human S345-p 447910 ELLCLRRsSLKAYGN receptor desensitization, inhibited; receptor recycling, inhibited; receptor desensitization, altered; intracellular localization cytoskeletal reorganization 11146000; 24003153; 27646272; 9461522 11 2 0 -FZR1 FZR1 UBIQUITIN LIGASE; Ubiquitin conjugating system Q9UM11 51343 19p13.3 human T32-p 3215934 TEMRRTLtPASSPVS protein stabilization 30498084 1 6 2 AURKA stabilization -UBA2 SAE2 EC 6.3.2.-; EC 6.3.2.19; Ligase; Motility/polarity/chemotaxis; SUMO LIGASE; SUMO conjugating system; SUMO ligase; UBIQUITIN LIGASE; Ubiquitin conjugating system; Ubiquitin ligase Q9UBT2 10054 19q13.11 human K630-sm 10304921 KRSRIEQkEELDDVI UBA2_C intracellular localization 23095757 2 3 0 nuclear localization -ELAVL1 HuR RNA-binding Q15717 1994 19p13.2 human R217-me 477190 PVHHQAQrFRFSPMG RNA stability, altered 23837869 2 0 0 represses replicative senescence, differential regulation of mRNA stability -FAM83A FAM83A Unknown function Q86UY5 84985 8q24.13 human Y138-p 463316 EKSSATVyFQTVKHN FAM83 ubiquitination; intracellular localization carcinogenesis, induced; cell growth, induced; transcription, induced; signaling pathway regulation 36797256 1 3 164 regulates ?-catenin nuclear translocation, ubiquitination and stability, enhances Wnt/?-catenin signaling -PDHA1 PDHA1 Amino Acid Metabolism - valine, leucine and isoleucine biosynthesis; Carbohydrate Metabolism - butanoate; Carbohydrate Metabolism - citrate (TCA) cycle; Carbohydrate Metabolism - glycolysis and gluconeogenesis; Carbohydrate Metabolism - pyruvate; EC 1.2.4.1; Mitochondrial; Oxidoreductase P08559 5160 Xp22.12 human K83-ac 1196409 LKADQLYkQKIIRGF E1_dh enzymatic activity, inhibited 33327751 1 3 8 IL-1? production, NLRP3 in?ammasome activation, lactate accumulation -Ager RAGE Cell cycle regulation; Membrane protein, integral; Motility/polarity/chemotaxis; Receptor, misc. Q62151 11596 17|17 B1 mouse S376-p 4731271 EERKAPEsQEDEEER intracellular localization DNA repair, induced; carcinogenesis, induced; signaling pathway regulation 23318458; 28977635 2 2 0 -TP73 p73 DNA-binding; Transcription factor; Tumor suppressor O15350 7161 1p36.32 human T86-p 449047 AASASPYtPEHAASV protein degradation; intracellular localization; activity, inhibited carcinogenesis, induced; cell growth, induced; apoptosis, induced; chromatin organization, altered; apoptosis, inhibited; transcription, inhibited p73(DISRUPTS) 12676926; 15985436; 22002055; 36721000 4 0 0 -Pdpk1 PDK1 EC 2.7.11.1; KINASE; Kinase, protein; Nuclear receptor co-regulator; Protein kinase, AGC; Protein kinase, Ser/Thr (non-receptor) Q9Z2A0 18607 17|17 A3.3 mouse S163-p 465670 EKLYFGLsYAKNGEL Pkinase protein conformation; enzymatic activity, induced 16751192 1 1 0 -MALT1 MALT1 Adaptor/scaffold; Apoptosis; EC 3.4.22.-; Ligase; Nuclear export; Protease; UBIQUITIN LIGASE; Ubiquitin conjugating system Q9UDY8 10892 18q21.32 human K714-ub 2134707 VGKPLIAkLDMHRGL MALT1_Ig protein degradation; molecular association, regulation IKKA(INDUCES) 17948050 1 1 0 activation of NF-kB pathway and IL-2 induction -GFAP GFAP Cytoskeletal P14136 2670 17q21.31 human Y242-p 462302 LKEIRTQyEAMASSN Filament cytoskeletal reorganization 24003221 1 1 2 -YWHAZ 14-3-3 zeta Adaptor/scaffold; Motility/polarity/chemotaxis P63104 7534 8q22.3 human S58-p 449833 VVGARRSsWRVVSSI 14-3-3 protein degradation; molecular association, regulation; intracellular localization apoptosis, altered 14-3-3 zeta(DISRUPTS); 14-3-3 zeta(INDUCES); ASK1(DISRUPTS); Tau iso3(DISRUPTS); 14-3-3 epsilon(DISRUPTS); p53(DISRUPTS); HSP20(DISRUPTS) 11956222; 16376338; 18559254; 19451227; 21081103; 35321476 15 1 5 -ATP4A ATP4A EC 3.6.3.10; Energy Metabolism - oxidative phosphorylation; Hydrolase; Membrane protein, integral; Membrane protein, multi-pass; Transporter; Transporter, ion channel P20648 495 19q13.12 human Y7-p 484289 _MGKAENyELYSVEL H-K_ATPase_N protein conformation 12480547 3 0 10 Structure indicates tyrosine sequential phosphorylation at Y10 and subsequent Y7 which may induce activation of ATP4A. -SMC3 SMC3 Cell cycle regulation; DNA repair, damage Q9UQE7 9126 10q25.2 human S1067-p 453059 GDVEGSQsQDEGEGS SMC_N phosphorylation cell cycle regulation 18442975 2 59 45 facilitates phosphorylation of S1083; required for intra-S phase checkpoint -NFKBIA IkB-alpha DNA-binding; Inhibitor P25963 4792 14q13.2 human S283-p 451523 NLQMLPEsEDEESYD protein degradation 8657113 3 1 0 S283/T291/T299A triple mutant showed increased IkB-alpha stability. -MAF MAF Cell development/differentiation; DNA-binding; Oncoprotein; Transcription factor; Tumor suppressor O75444 4094 16q23.2 human S70-p 487503 PCSSVPPsPSFSAPS transcription, altered 17897790 1 0 0 sites behave in a dramatic cell type-specific manner -DIAPH2 Diaphanous-2 iso4 Cytoskeletal; Motility/polarity/chemotaxis Q17R91 1730 Xq21.33 human S820-p 18707505 HINNIKPsIIAVTLA FH2 cell cycle regulation; chromatin organization, altered; cytoskeletal reorganization 21397845 1 0 0 mutation of this site disrupts metaphase chromosome alignment -TET1 TET1 DNA-binding; EC 1.14.11.n2; Oxidoreductase Q8NFU7 80312 10q21.3 human S1976-p 1881549504 PPSDEPLsDDPLSPA protein stabilization carcinogenesis, induced; cell growth, induced; apoptosis, inhibited; transcription, induced 36989375 1 0 0 -Hsf1 HSF1 DNA-binding; Transcription factor P38532 15499 15 D3|15 35.95 cM mouse T142-p 449066 DSVTRLLtDVQLMKG molecular association, regulation; protein conformation apoptosis, inhibited; transcription, induced 24312621 4 1 0 critical oxidative stress-responsive circadian transcriptome; BMAL1-HSF1 dimerization -SNAI1 Snail1 C2H2-type zinc finger protein; Transcription factor O95863 6615 20q13.13 human K146-ac 1877752103 LAQLSEAkDLQARKA protein degradation; molecular association, regulation; ubiquitination carcinogenesis, induced BTRC(INDUCES); FBXL14(INDUCES); BRD4(INDUCES) 31311807 1 0 0 BRD4 interacts with acetylated Snail to suppress its ubiquitination and degradation by competing with FBXL14 and BRD8 for binding to Snail1 -TUBB4A TUBB4 Cytoskeletal; Motility/polarity/chemotaxis P04350 10382 19p13.3 human K19-m1 58123406 CGNQIGAkFWEVISD Tubulin molecular association, regulation L3MBTL iso4(INDUCES) 23583077 0 1 0 -Nrl NRL DNA-binding; Transcription factor P54846 18185 14 C3|14 28.19 cM mouse S50-p 478419 PYSSVPPsPTFSEPG molecular association, regulation chromatin organization, altered; transcription, induced Tip60(INDUCES) DNA(INDUCES) 22354990 2 0 1 -KDM1A LSD1 DEMETHYLASE; Demethylase; EC 1.-.-.-; Nuclear receptor co-regulator; Oxidoreductase; Transcription factor O60341 23028 1p36.12 human S111-p 3828907 TPEGRRTsRRKRAKV cell motility, induced; cell growth, induced DNA(INDUCES) 27572339 4 1 10 epithelial-mesenchymal transition (EMT), facilitated the H3K4me demethylation -CASP8 CASP8 iso4 Apoptosis; EC 3.4.22.61; Protease Q14790-4 841 2q33.1 human K215-ub 573769294 NDYEEFSkGEELCGV ubiquitination apoptosis, inhibited 30807646 1 3 0 CUL7 ubiquitination inhibits Caspase-8 cleavage and apoptosis -Clic4 CLIC4 Membrane protein, integral Q9QYB1 29876 4|4 D3 mouse S108-p 4782152 PPKYLKLsPKHPESN protein stabilization apoptosis, induced 30237421 1 4 0 -Cbx3 CBX3 DNA-binding P23198 12417 6 B3|6 24.89 cM mouse S93-p 457001 KDGTKRKsLSDSESD intracellular localization transcription, induced 26021315 5 57 61 P-Ser83-HP1 colocalized with Centrin-2 in sperm mid-piece, early embryonic genome activation, regulation of mitosis-associated gene expression networks -Ppp1r1b DARPP-32 Motility/polarity/chemotaxis; Protein phosphatase, regulatory subunit Q60829 19049 11|11 D mouse S97-p 457675 NLSENQAsEEEDELG DARPP-32 molecular association, regulation; intracellular localization; phosphorylation signaling pathway regulation PPP1CA(INDUCES) 18496528; 36055413 8 13 23 inhibits GluR1 dephosphorylation, thus inducing DARPP-32-PP1-GRIA1 signaling -H3C1 H3 DNA-binding P68431 8350 6p22.2 human K115-ac 3652257 NLCAIHAkRVTIMPK Histone molecular association, regulation chromatin organization, altered polybromo 1(INDUCES) DNA(DISRUPTS) 19520870; 20368734 2 1 42 acetylation facilitates nucleosome repositioning; varying site specificity binding for each bromodomain 1-6 -PHLDA1 PHLDA1 Apoptosis; Nucleolus Q8WV24 22822 12q21.2 human S95-p 22459800 PLCLLRVsLLCALRA protein degradation; intracellular localization carcinogenesis, induced; cell motility, induced; apoptosis, induced 21807936 1 0 0 ; S95A mutant promotes Aurora A degradation and ubiquitylation -IQCB1 IQCB1 Cell development/differentiation Q15051 9657 3q13.33|3q21.1 human K528-ub 95155300 LMKAPSLkEAEGKEP intracellular localization cell cycle regulation; cytoskeletal reorganization 28498859 1 2 0 regulation of cilia formation -SUPT5H SPT5 RNA-binding; Transcription, coactivator/corepressor O00267 6829 19q13.2 human T784-p 458816 MYGSGSRtPMYGSQT transcription, induced; transcription, altered 10757782; 16427012 2 2 12 required for c-fos induction and activation in vivo -Rab3il1 RAB3IL1 GEF; GEF, Rab Q8VDV3 74760 19|19 A mouse S169-p 467058 VITSTPAsPNRELHP Sec2p exocytosis, induced; cell differentiation, induced 28096466 2 21 35 required for myogenesis and promotes IL-6 secretion in skeletal muscle -ANTXR2 ANTXR2 Membrane protein, integral; Receptor, misc. P58335 118429 4q21.21 human Y380-p 3781577 WPTVDASyYGGRGVG ubiquitination 20080640 1 10 110 -Card11 CARD11 Adaptor/scaffold Q8CIS0 108723 5|5 G2 mouse S564-p 457637 QPHRSRSsIMSITAE activity, induced; molecular association, regulation; enzymatic activity, induced signaling pathway regulation Bcl-10(INDUCES) 16356855; 19917688; 31391255 7 1 0 antigen receptor signaling -GLI3 GLI3 C2H2-type zinc finger protein; Transcription factor P10071 2737 7p14.1 human K773-ub 6097711 RRNPAGTkWMEHVKL protein processing 16705181 1 0 0 -Hnrnpa1 hnRNP A1 Nuclear export; RNA splicing; RNA-binding; Spliceosome P04256 29578 7q36 rat S95-p 476057 RAVSREDsQRPGAHL activity, inhibited 7727389 1 16 23 -ERG ERG DNA-binding; Oncoprotein; Transcription factor P11308 2078 21q22.2 human S38-p 50259802 TEMTASSsSDYGQTS protein degradation; molecular association, regulation cell motility, inhibited SPOP(INDUCES) 26344095 1 1 0 -CDC25B CDC25B EC 3.1.3.48; Motility/polarity/chemotaxis; Nuclear receptor co-regulator; PHOSPHATASE; Protein phosphatase, dual-specificity P30305 994 20p13 human T355-p 3189697 NKRRRSVtPPEEQQE M-inducer_phosp cell cycle regulation 23708659 1 2 5 -CHMP7 CHMP7 Q8WUX9 91782 8p21.3 human S441-p 4763991 GLVPSSKsPKRQLEP Snf7 molecular association, regulation cell cycle regulation CHMP7(DISRUPTS); LEMD2(DISRUPTS) 34286694 1 8 0 -FOXP3 FOXP3 C2H2-type zinc finger protein; Cell cycle regulation; DNA-binding; Transcription factor Q9BZS1 50943 Xp11.23 human S270-p 56786300 KMALTKAsSVASSDK protein degradation; ubiquitination 27432879 1 1 0 -PTPN6 SHP-1 EC 3.1.3.48; Motility/polarity/chemotaxis; PHOSPHATASE; Protein phosphatase, tyrosine (non-receptor) P29350 5777 12p13.31 human S557-p 11086952 AKASRTSsKHKEDVY enzymatic activity, induced cell adhesion, induced; signaling pathway regulation 21177494 1 6 68 Src activation via SHP-1 and SHP-2, and then ERK activation -Xrcc6 Ku70 DNA repair, damage; DNA-binding; EC 3.6.4.-; EC 4.2.99.-; Helicase; Nuclear receptor co-regulator; RNA-binding P23475 14375 15 E1|15 38.33 cM mouse K568-m3 1883494505 ELKAHFRkGTLGKLT intracellular localization apoptosis, inhibited 35545041 1 0 0 enriched in cytoplasm, the methylation of KU70-K570 is a prerequisite for the acetylation of KU70 -Traf6 TRAF6 EC 6.3.2.-; Ligase; UBIQUITIN LIGASE; Ubiquitin conjugating system; Ubiquitin ligase P70196 22034 2|2 E2 mouse T330-p 60176100 ELTAKMEtQSMYVGE intracellular localization 27818144 1 0 0 nuclear localization -Ntsr2 NTSR2 GPCR, family 1; Membrane protein, integral; Membrane protein, multi-pass; Receptor, GPCR P70310 18217 12 A1.1|12 7.98 cM mouse Y237-p 3129400 VNHLVALySQVPSAS 7tm_1; TM receptor recycling, altered 11801734 1 0 0 NT stimulation led to large intracellular vesicles under the plasma membrane in the Y238A mutant. -NR3C2 MCR DNA-binding; Nuclear receptor P08235 4306 4q31.23 human S196-p 25692901 EKSPSVCsPLNMTSS protein degradation; ubiquitination transcription, inhibited 22798426 1 0 0 -ACTN1 ACTN1 Cytoskeletal; Motility/polarity/chemotaxis P12814 87 14q24.1|14q22-q24 human Y12-p 450200 DSQQTNDyMQPEEDW molecular association, regulation; phosphorylation cell motility, altered; cytoskeletal reorganization Src(INDUCES); ITGA2B(INDUCES) 16291744; 20940419; 23454549 4 2 3 required for dorsal stress fiber establishment, transverse arc maintenance, and focal adhesion maturation; inhibits PAR1-induced ITGA2b activation in CMK; Phosphorylation of ACTN1 Y12 is required for PTP 1B to dephosphorylate FAK Y397. Y12F mutation or no expression of ACTN1 significantly decreases the FAK Y397 dephosphorylation by PTP 1B. Src's binding to phospho-Y12 ACTN1 competes with Src's binding to FAK. -CENPQ CENPQ Q7L2Z9 55166 6p12.3 human S138-p 18007846 MEDLTNVsSLLNMER CENP-Q molecular association, regulation; intracellular localization DNA(DISRUPTS) 25670858 1 5 0 CENPQ phosphorylation promotes the delocalization of the PBIP1-CENPQ complex from kinetochores -Clec7a dectin-1 Membrane protein, integral Q6QLQ4 56644 6|6 F3 mouse Y15-p 36396303 ENLDEDGyTQLDFST molecular association, regulation endocytosis, induced; transcription, induced; signaling pathway regulation Syk(INDUCES); SHIP(INDUCES); Cbl-b(DISRUPTS) 25246527; 26416276; 27428899 3 1 0 -CD247 CD3Z Membrane protein, integral; Receptor, misc. P20963 919 1q24.2 human Y123-p 448934 KDKMAEAySEIGMKG ITAM intracellular localization; phosphorylation 16919488; 18760640 3 13 314 -STAM2 STAM2 Adaptor/scaffold; Motility/polarity/chemotaxis O75886 10254 2q23.3 human Y371-p 449670 LVNEAPVySVYSKLH molecular association, regulation UBE2D2(DISRUPTS) 18626516 1 26 440 -EEF2K EEF2K EC 2.7.11.20; KINASE; Kinase, protein; Protein kinase, Ser/Thr (non-receptor); Protein kinase, atypical; Translation O00418 29904 16p12.2 human S398-p 450686 DSLPSSPsSATPHSQ autophagy, induced; apoptosis, inhibited 23182879 3 2 2 -Tnni3 TNNI3 Actin-binding; Motility/polarity/chemotaxis; Motor P23693 29248 1q12 rat S151-p 451822 TLRRVRIsADAMMQA Troponin molecular association, regulation; protein conformation TNNC1(INDUCES) 20540949 9 4 0 sensitizes structural changes to Ca2+ -DAP DAP Autophagy P51397 1611 5p15.2 human S51-p 471098 DQEWESPsPPKPTVF DAP activity, inhibited autophagy, altered 20537536 1 54 1 dephosphorylated form of DAP acts as an active suppressor of autophagy -Ksr1 KSR KINASE; Kinase, protein; Protein kinase, Ser/Thr (non-receptor); Protein kinase, TKL Q61097 16706 11 B5|11 46.74 cM mouse T274-p 449299 AKLKPPRtPPPPSRK protein degradation; intracellular localization cell cycle regulation; cell growth, altered 11741955; 15371409 4 6 1 -PRL prolactin Cytokine; Motility/polarity/chemotaxis; Secreted; Secreted, signal peptide P01236 5617 6p22.3 human S207-p 451732 LHCLRRDsHKIDNYL Hormone_1 protein conformation 19555049 3 1 0 phosphorylated form of prolactin has a higher affinity for heparin -PPP2R5A PPP2R5A Motility/polarity/chemotaxis; Protein phosphatase, regulatory subunit Q15172 5525 1q32.3 human S41-p 3196904 RQKRSQGsSQFRSQG enzymatic activity, inhibited 24225947 1 33 38 increases Ca++ release -SH3BP2 SH3BP2 Adaptor/scaffold P78314 6452 4p16.3 human Y183-p 449092 HDDEDDSyLEPDSPE molecular association, regulation transcription, altered VAV1(INDUCES) 15751964 4 0 0 -HNRNPK hnRNP K RNA splicing; RNA-binding; Spliceosome P61978 3190 9q21.32 human K139-m1 58123401 CLNYQHYkGSDFDCE molecular association, regulation L3MBTL iso4(INDUCES) 23583077 0 1 0 -GRB2 GRB2 Adaptor/scaffold; Cell development/differentiation; Motility/polarity/chemotaxis P62993 2885 17q25.1 human Y209-p 448512 TGMFPRNyVTPVNRN molecular association, regulation cell growth, induced; cell growth, altered SOS1(DISRUPTS) 11726515; 19273609; 36163549 4 4 216 -Cry1 CRY1 DNA-binding; Lyase; Transcription, coactivator/corepressor P97784 12952 10 C1|10 41.63 cM mouse S588-p 11952906 LSSGKRPsQEEDAQS protein stabilization 24158435 2 9 0 lengthened circadian periods -Eif4ebp1 4E-BP1 Translation; Translation initiation Q60876 13685 8 A2|8 15.95 cM mouse T45-p 447496 GGTLFSTtPGGTRII eIF_4EBP molecular association, regulation transcription, induced; translation, induced; signaling pathway regulation EIF4E(DISRUPTS); EIF4E(INDUCES) 11875068; 17510058; 18851840; 33567340; 34704268 156 36 91 -Plcg1 PLCG1 Carbohydrate Metabolism - inositol phosphate; EC 3.1.4.11; Motility/polarity/chemotaxis; Phospholipase P10686 25738 3q42 rat Y771-p 448575 IGTAEPDyGALYEGR enzymatic activity, induced 1708307 16 41 552 Y1253F inhibited full activation. ; Y771F mutation completely blocked activation, while Y774F enhanced activation -CDK11B CDK11B Apoptosis; Cell cycle regulation; EC 2.7.11.22; KINASE; Kinase, protein; Motility/polarity/chemotaxis; Protein kinase, CMGC; Protein kinase, Ser/Thr (non-receptor) P21127 984 1p36.33 human S115-p 455902 KRRHRSHsAEGGKHA molecular association, regulation 14-3-3 beta(INDUCES); 14-3-3 theta(INDUCES); 14-3-3 epsilon(INDUCES); 14-3-3 gamma(INDUCES) 15883043 1 6 5 -Coro1a coronin 1A Cytoskeletal; Motility/polarity/chemotaxis O89053 12721 7 69.25 cM|7 F3 mouse S426-p 31905585 PEPSGTPsSDTVSRL Trimer_CC molecular association, regulation; enzymatic activity, induced PPM1D(INDUCES) 37386173 1 5 0 induces PLC activity -TH TH iso4 Amino Acid Metabolism - tyrosine; EC 1.14.16.2; Endoplasmic reticulum; Mitochondrial; Oxidoreductase; Vesicle P07101-4 7054 11p15.5 human S44-p 448545 RFIGRRQsLIEDARK TOH_N enzymatic activity, induced 7901013 62 11 11 -MAPK7 ERK5 EC 2.7.11.24; KINASE; Kinase, protein; Protein kinase, CMGC; Protein kinase, Ser/Thr (non-receptor) Q13164 5598 17p11.2 human K22-sm 2887212 AEPPGPVkAEPAHTA molecular association, regulation; intracellular localization cell growth, induced; transcription, induced HSP90A(DISRUPTS) 32209980 4 0 0 nuclear translocation; Hsp90 dissociation from the ERK5-Cdc37 complex -ADAR ADAR EC 3.5.4.37; Hydrolase; Nucleolus; RNA processing; RNA-binding P55265 103 1q21.3 human T1033-p 1868546602 RLGERLRtMSCSDKI A_deamin enzymatic activity, inhibited 31095429 1 0 0 -BACE1 BACE EC 3.4.23.46; Membrane protein, integral; Protease P56817 23621 11q23.3 human K300-ac 478254 TNLRLPKkVFEAAVK Asp protein stabilization; intracellular localization 17425515 1 1 0 regulates translocation through secretory pathway -Grin1 NMDAR1 Channel, calcium; Channel, ligand-gated; Membrane protein, integral; Membrane protein, multi-pass P35439 24408 3p13 rat S584-p 1871177708 LYLLDRFsPFGRFKV Lig_chan intracellular localization; activity, inhibited cell cycle regulation 33184446 1 0 0 -Pip5k1c PIP5K1C Carbohydrate Metabolism - inositol phosphate; EC 2.7.1.68; Kinase, lipid; Motility/polarity/chemotaxis O70161 18717 10|10 C1 mouse Y644-p 450241 TDERSWVySPLHYSA molecular association, regulation; intracellular localization; enzymatic activity, induced cytoskeletal reorganization talin 1(INDUCES) 14691141; 15623515 6 0 0 -SIRT1 SIRT1 Apoptosis; DEACETYLASE; Deacetylase; EC 3.5.1.-; Nuclear receptor co-regulator Q96EB6 23411 10q21.3 human K622-me 58128900 SVAGTVRkCWPNRVA molecular association, regulation L3MBTL iso4(INDUCES) 23583077 1 1 0 -FCRL3 FCRL3 Adaptor/scaffold; Membrane protein, integral Q96P31 115352 1q23.1 human Y662-p 469981 PGDSNPIySQIWSIQ molecular association, regulation ZAP70(INDUCES) 12051764 1 0 0 -CTBP2 CTBP2 Nuclear receptor co-regulator; Transcription, coactivator/corepressor P56545 1488 10q26.13 human K10-ac 461009 LVDKHKVkRQRLDRI intracellular localization transcription, induced 16356938 1 0 0 reduction of acetylation represses transcription -GALNT2 GALNT2 EC 2.4.1.41; Glycan Metabolism - O-glycan biosynthesis; Membrane protein, integral; Transferase Q10471 2590 1q42.13 human S529-ac 25336510 WEQIEGNsKLRHVGS Ricin_B_lectin molecular association, regulation; protein conformation Other(INDUCES) 21651894 0 1 0 induces binding to glycan -Rasgrf1 RASGRF1 GEF; GEF, Ras P28818 192213 8q31 rat S575-p 18710202 QEKAAWTsDIIQCVD PH protein degradation 21382555 1 1 0 -CENPQ CENPQ Q7L2Z9 55166 6p12.3 human T256-p 40245502 SQMKSMStFIEEAYK CENP-Q molecular association, regulation; intracellular localization DNA(DISRUPTS) 25670858 1 1 0 CENPQ phosphorylation promotes the delocalization of the PBIP1-CENPQ complex from kinetochores -NR3C1 GR DNA-binding; Mitochondrial; Nuclear receptor; Transcription factor P04150 2908 5q31.3 human K480-ac 6741601 CPACRYRkCLQAGMN zf-C4 molecular association, regulation transcription, inhibited DNA(DISRUPTS) 19141540 1 0 0 -NFATC1 NFAT2 DNA-binding; Transcription factor O95644 4772 18q23 human S269-p 448862 PCNKRKYsLNGRQPP activity, induced; intracellular localization; activity, inhibited; phosphorylation carcinogenesis, induced; cell motility, induced; transcription, induced 12351631; 31730483; 9072970 3 6 1 phosphorylation creates predicted overlapping GSK3B phosphorylation sites; multiple sites mutatnt -MOB1A MOB1A Protein kinase, regulatory subunit Q9H8S9 55233 2p13.1 human T35-p 3212769 LLKHAEAtLGSGNLR Mob1_phocein activity, induced; molecular association, regulation; protein conformation; phosphorylation cell cycle regulation; carcinogenesis, inhibited; cell growth, inhibited; apoptosis, induced; signaling pathway regulation NDR1(INDUCES); MST2(INDUCES); LATS1(INDUCES); MST1(DISRUPTS) 26108669; 28373297; 32513747; 36622276; 37319316; 37392812 13 45 34 -ING1 ING1 iso2 Tumor suppressor Q9UK53-2 3621 13q34 human K193-sm 34483100 KKKRSKAkAEREASP protein degradation; molecular association, regulation cell differentiation, induced; transcription, altered HIF1A(DISRUPTS) DNA(DISRUPTS) 24903338; 25611387 2 0 0 induces HIF1 degradation -Fyn Fyn EC 2.7.10.2; KINASE; Kinase, protein; Oncoprotein; Protein kinase, TK; Protein kinase, tyrosine (non-receptor) P39688 14360 10 B1|10 20.51 cM mouse Y420-p 447882 RLIEDNEyTARQGAK PK_Tyr_Ser-Thr enzymatic activity, induced 12545173; 16339530; 23602477 31 94 3048 -Apbb1 Fe65 Adaptor/scaffold; Apoptosis; Transcription regulation P46933 29722 1q32 rat S611-p 2035401 ECRVRFLsFLAVGRD PID intracellular localization 18304449 2 0 0 -H2AX H2AX DNA repair, damage; DNA-binding; Helicase P16104 3014 11q23.3 human K119-ub 3945267 QAVLLPKkTSATVGP Histone_H2A_C protein degradation; molecular association, regulation; intracellular localization; phosphorylation cell cycle regulation; DNA repair, induced ATM(INDUCES); UBE2T(INDUCES) 19305155; 21676867; 21690091; 31533041; 33087136 7 13 156 ATM recruitment, H2AX S139 phosphorylation ; CHK1 phosphorylation and activation, cell cycle arrest, the DNA damage response and radioresistance -MAVS MAVS Adaptor/scaffold; Membrane protein, integral Q7Z434 57506 20p13 human S233-p 3204105 SFQPLARsTPRASRL molecular association, regulation PLK1(INDUCES) 19546225 1 4 0 -Tfcp2l1 TFCP2L1 DNA-binding Q3UNW5 81879 1|1 E2.3 mouse T177-p 38489957 HCISTEFtPRKHGGE CP2 molecular association, regulation cell cycle regulation; carcinogenesis, induced; cell growth, inhibited; cell differentiation, induced; transcription, altered DNA(INDUCES) 31709755 1 1 1 induces binding to target genes, inhibits cell death -TRIM71 TRIM71 UBIQUITIN LIGASE; Ubiquitin conjugating system; Ubiquitin ligase Q2Q1W2 131405 3p22.3 human S3-p 18914372 _____MAsFPETDFQ protein stabilization; molecular association, regulation; ubiquitination carcinogenesis, inhibited UBE1(DISRUPTS); UBE2D3(DISRUPTS); ubiquitin(DISRUPTS) 31160797 1 2 0 inhibits ubiquitination -BRCA1 BRCA1 EC 6.3.2.-; Nuclear receptor co-regulator; Transcription, coactivator/corepressor; Tumor suppressor; UBIQUITIN LIGASE; Ubiquitin conjugating system; Ubiquitin ligase P38398 672 17q21.31 human S1164-p 36135579 GEIKEDTsFAENDIK intracellular localization DNA repair, induced 26745677 2 2 0 important for foci formation following DSB -LMO2 LMO2 Adaptor/scaffold; Oncoprotein P25791 4005 11p13 human K78-ac 1879723003 LYYKLGRkLCRRDYL molecular association, regulation; activity, inhibited cell differentiation, inhibited; cell growth, inhibited; apoptosis, induced; transcription, inhibited LDB1(DISRUPTS) 31366618 1 0 0 inactivation of TAL-1 complex, LMO2 is deacetylated by PBEF/SIRT2 during the early stages of hematopoietic differentiation -Tbx21 TBX21 DNA-binding; Transcription factor Q9JKD8 57765 11|11 D mouse Y525-p 458297 KETEGQFyNYFPN__ molecular association, regulation transcription, altered GATA3(INDUCES) 15662016 1 0 0 -DEPTOR DEPTOR Apoptosis Q8TB45 64798 8q24.12 human Y289-p 1875073002 SSCGSSGyFSSSPTL protein stabilization; molecular association, regulation; ubiquitination; phosphorylation cytoskeletal reorganization mTOR(DISRUPTS) 34634301 1 0 0 inhibits ubiquitination, induces AKT phosphorylation, decrease mTOR inhibitory activity -HIPK2 HIPK2 EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, CMGC; Protein kinase, Ser/Thr (non-receptor) Q9H2X6 28996 7q34 human K1191-ub 3059901 GYPLSPAkVNQYPYI protein degradation; ubiquitination 17349959; 18536714 2 0 0 -Tiam1 TIAM1 GEF; GEF, Rac/Rho; Motility/polarity/chemotaxis; Oncoprotein Q60610 21844 16 C3.3|16 51.5 cM mouse S60-p 11485305 EVSTRSSsTPSIPQS protein degradation; molecular association, regulation 14-3-3 zeta(INDUCES) 19899799 2 1 0 -POU5F1 Oct4 DNA-binding; Transcription factor Q01860 5460 6p21.33 human K156-m1 57951801 FAKLLKQkRITLGYT Pou protein stabilization; molecular association, regulation transcription, induced SOX2(INDUCES) 27369080 1 1 0 -RIN1 Rin1 GEF; GEF, Rab Q13671 9610 11q13.2 human S291-p 1244499 CQLLRREsSVGYRVP molecular association, regulation cell motility, inhibited HRas(INDUCES) 27137893 1 4 19 -Prkaa1 AMPKA1 Autophagy; EC 2.7.11.1; EC 2.7.11.26; EC 2.7.11.27; EC 2.7.11.31; KINASE; Kinase, protein; Protein kinase, CAMK; Protein kinase, Ser/Thr (non-receptor) P54645 65248 2q16 rat T183-p 448786 SDGEFLRtSCGSPNY Pkinase protein stabilization; molecular association, regulation; enzymatic activity, induced 14-3-3 beta(INDUCES); 14-3-3 sigma(INDUCES); 14-3-3 theta(INDUCES); 14-3-3 zeta(INDUCES); 14-3-3 epsilon(INDUCES); 14-3-3 gamma(INDUCES); 14-3-3 eta(INDUCES) 10642499; 12456889; 12764152; 17032173; 17082196; 17147517; 17253964; 20146253; 9305909 228 16 33 -Adcy6 ADCY6 Adenylyl cyclase; EC 4.6.1.1; Lyase; Membrane protein, integral; Membrane protein, multi-pass; Nucleotide Metabolism - purine; Transporter; Transporter, aquaporin family AAA40678 25289 7q36 rat S608-p 467271 AFSRTKDsKAFRQMG Adcy_cons_dom enzymatic activity, induced 11327830 1 0 0 -ACBD5 ACBD5 iso2 Lipid-binding; Membrane protein, integral Q5T8D3-2 91452 10p12.1 human S261-p 1876128610 IQHLTSDsDSEVYCD molecular association, regulation; phosphorylation VAPB(INDUCES) 35019937 1 1 0 induces phosphorylation at S269 -Cebpa C/EBP-alpha DNA-binding; Transcription factor P53566 12606 7 B2|7 21.02 cM mouse S21-p 448308 PMSSHLQsPPHAPSN activity, induced transcription, altered 18408001 10 1 0 impaired glucose uptake and Glut 4 expression -GTF2I GTF2I DNA-binding; Transcription, coactivator/corepressor P78347 2969 7q11.23 human S784-p 457075 GVPFRRPsTFGIPRL GTF2I transcription, induced 12082086 2 14 266 -JUN Jun Oncoprotein; Transcription factor P05412 3725 1p32.1 human T286-p 17737605 RLEEKVKtLKAQNSE bZIP_1 carcinogenesis, altered; cell growth, altered 21177766 1 0 1 -Scnn1g ENaC-gamma Channel, sodium; Membrane protein, integral; Membrane protein, multi-pass; Transporter, ion channel P37091 24768 1q36 rat K8-ub 486251 MAPGEKIkAKIKKNL receptor recycling, inhibited; protein degradation; intracellular localization 9351815 1 0 0 -Syngap1 SynGAP iso3 GAP; GAP, Ras Q9QUH6-3 192117 20p12 rat S326-p 4792707 GSGGGGGsGGGSGGK molecular association, regulation; intracellular localization HRas(INDUCES) 21382555 1 1 0 -RPS6KA1 p90RSK EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, AGC; Protein kinase, Ser/Thr (non-receptor); Translation Q15418 6195 1p36.11 human S363-p 447989 TSRTPKDsPGIPPSA Pkinase_C enzymatic activity, induced 23708659 42 47 4 -GCM1 GCM1 DNA-binding; Transcription factor Q9NP62 8521 6p12.1 human K409-ac 460589 SLPSKSSkWDFEEEM protein stabilization; ubiquitination transcription, induced 16166624 1 0 0 inhibits ubiquitination -EIF5A EIF5A Translation; Translation initiation P63241 1984 17p13.1 human K47-ac 458947 IVEMSTSkTGKHGHA intracellular localization 7578077 2 7 6 excluded from nucleus and localized in cytoplasm, reduces the rate of hypucine synthesis -BRCA1 BRCA1 EC 6.3.2.-; Nuclear receptor co-regulator; Transcription, coactivator/corepressor; Tumor suppressor; UBIQUITIN LIGASE; Ubiquitin conjugating system; Ubiquitin ligase P38398 672 17q21.31 human S694-p 4787521 QTSKRHDsDTFPELK protein stabilization 20085797 1 19 3 -KLF13 KLF13 C2H2-type zinc finger protein; DNA-binding Q9Y2Y9 51621 15q13.3 human K166-ac 460598 DLESPQRkHKCHYAG molecular association, regulation DNA(DISRUPTS) 12758070 1 0 0 -Exoc8 EXOC8 Vesicle O54924 245709 19q12 rat S31-p 40510667 VKQLSQQsDGDRDLQ Vps51 molecular association, regulation exocytosis, inhibited Sec5(DISRUPTS); EXOC8(DISRUPTS) 28325821 1 2 1 -NT5C2 NT5C2 Cofactor and Vitamin Metabolism - nicotinate and nicotinamide; EC 3.1.3.5; Hydrolase; Nucleotide Metabolism - purine; Nucleotide Metabolism - pyrimidine P49902 22978 10q24.32-q24.33 human S502-p 3191299 VDINEMEsPLATRNR protein conformation; enzymatic activity, induced carcinogenesis, induced 35984649 1 8 0 -ADRA1B ADRA1B GPCR, family 1; Membrane protein, integral; Membrane protein, multi-pass; Receptor, GPCR P18841 101843941 hamster S404-p 451004 RSQSRKDsLDDSGSC receptor desensitization, altered 9353340 1 4 3 -NANOG NANOG Cell development/differentiation; DNA-binding; Transcription factor Q9H9S0 79923 12p13.31 human S79-p 28070708 PKGKQPTsAEKSVAK transcription, induced 23708658 1 2 0 -Ptpn6 SHP-1 EC 3.1.3.48; Motility/polarity/chemotaxis; PHOSPHATASE; Protein phosphatase, tyrosine (non-receptor) P29351 15170 6 F2|6 59.17 cM mouse S591-p 454019 DKEKNKGsLKRK___ protein processing; intracellular localization; enzymatic activity, inhibited 17575265; 18617527; 20351292; 28811476 9 2 15 -ITGB1 ITGB1 Cell adhesion; Cell surface; Membrane protein, integral; Motility/polarity/chemotaxis; Receptor, misc. P05556 3688 10p11.22 human S785-p 452040 GENPIYKsAVTTVVN Integrin_b_cyt cytoskeletal reorganization 20926684 5 11 17 -Nlgn2 NLGN2 Membrane protein, integral Q62888 117096 10q24 rat S714-p 487169 ELRCRRLsPPGGSGS receptor internalization, induced; intracellular localization; activity, inhibited neural plasticity 27805570; 35727864 3 9 0 -Mafa MAFA DNA-binding; Oncoprotein; Transcription factor; Tumor suppressor Q8CF90 378435 15|15 D3 mouse S65-p 5403102 PCSSVPSsPSFCAPS protein degradation; molecular association, regulation; ubiquitination; phosphorylation transcription, induced; transcription, inhibited MAFA(INDUCES); PSME3(INDUCES) DNA(NOT_REPORTED) 19004825; 20208071; 21646385; 34644565 9 0 0 -H3-3A H3 DNA-binding Q71LE2 396970 pig K27-m3 1308913 LATKAARkSAPSTGG Histone cell differentiation, inhibited; transcription, inhibited 19536841; 32893712; 34943981 195 24 3 mesenchymal stem/stroma cells of obese pigs had suppressed transcription compared to lean pigs; tributyrin treatment: positive regulators of cell proliferation were enriched for H3K27me3 ; low levels of trimethylated H3K27 detected -MKNK1 Mnk1 iso2 EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, CAMK; Protein kinase, Ser/Thr (non-receptor); Translation Q9BUB5-2 8569 1p33 human T214-p 447622 ITTPELTtPCGSAEY Pkinase intracellular localization; enzymatic activity, induced 17590453 13 1 0 Leaves nucleus to cytoplasm upon phosphorylation. -ZFP36L1 BRF1 Transcription factor Q07352 677 14q24.1 human S92-p 470147 RFRDRSFsEGGERLL Tis11B_N protein stabilization; molecular association, regulation; intracellular localization cell growth, inhibited; transcription, altered; RNA stability, altered 14-3-3 beta(INDUCES) 15538381; 17030608; 18326031; 26280535 4 20 1 for its physiological effect phosphorylation of this site cooperates with phosphorylation of S90 and S203; inhibits BRF1-dependent AMD ( ARE-mediated mRNA decay); senescence-associated secretory phenotype (SASP) -Mapt Tau ACETYLTRANSFERASE; Acetyltransferase; Cytoskeletal P10637 17762 11 67.79 cM|11 E1 mouse T523-p 449079 KKVAVVRtPPKSPSA receptor internalization, induced; intracellular localization; phosphorylation neural plasticity; transcription, induced 24653715; 27834631; 33428131; 34158075; 34551296; 36186135 149 48 14 -HOXA11 HOXA11 DNA-binding; Transcription factor P31270 3207 7p15.2 human T119-p 55571506 ANVYHHPtPAVSSNF DUF3528 molecular association, regulation transcription, induced CBP(INDUCES) 27239043 1 1 0 -Idh2 IDH2 Carbohydrate Metabolism - citrate (TCA) cycle; EC 1.1.1.42; Mitochondrial; Other Amino Acids Metabolism - glutathione; Oxidoreductase P54071 269951 7 D2|7 45.43 cM mouse K413-ac 1204122 VESGAMTkDLAGCIH Iso_dh enzymatic activity, inhibited 36654268 6 3 5 -HRAS HRas G protein; G protein, monomeric; G protein, monomeric, Ras; Motility/polarity/chemotaxis; Oncoprotein P01112 3265 11p15.5 human K117-ub 31914117 PMVLVGNkCDLAART Ras enzymatic activity, induced 24247240 1 1 0 -YWHAE 14-3-3 epsilon Adaptor/scaffold P62258 7531 17p13.3 human K123-ac 11315832 ESKVFYYkMKGDYHR 14-3-3 molecular association, regulation SFRS6(DISRUPTS); PLEKHQ1(DISRUPTS); SFRS4(DISRUPTS); DOK3(DISRUPTS); TSC2(DISRUPTS); ARAF(DISRUPTS); LARP(DISRUPTS); SRm300(DISRUPTS); SF2(DISRUPTS); TSC22D1(DISRUPTS); GAB2(DISRUPTS); RAF1(DISRUPTS); VASP(DISRUPTS); HDAC4(DISRUPTS); TRA2B(DISRUPTS); GBF1(DISRUPTS) 19608861 0 2 5 -Ptk2 FAK iso2 EC 2.7.10.2; KINASE; Kinase, protein; Protein kinase, TK; Protein kinase, tyrosine (non-receptor) P34152-2 14083 15 D3|15 33.94 cM mouse S763-p 450196 SSEGFYPsPQHMVQT molecular association, regulation cell cycle regulation; cell differentiation, altered; carcinogenesis, induced; cell growth, altered DNAI1(INDUCES) 19201755 5 1 0 S770 FAK phosphorylation regulates centrosomes during mitosis, proliferation, tublogenesis, and tumor angiogenesis. -Cttn Cortactin Actin-binding; Cytoskeletal; Motility/polarity/chemotaxis Q60598 13043 7|7 F5 mouse Y421-p 447702 RPPSSPIyEDAAPFK molecular association, regulation; intracellular localization cell cycle regulation; cell motility, induced; cell motility, altered; cytoskeletal reorganization MTUS2(DISRUPTS); Arg(INDUCES); VAV2(INDUCES); Abl(INDUCES); FAK(DISRUPTS); smMLCK(INDUCES); N-WASP(INDUCES) 12408982; 15169891; 17343955; 18515860; 22078467; 22952866; 24891505; 27340123; 27451391; 28885660; 34439396 47 62 745 Tyr to Phe mutation of this site prevents FAK-mediated FA turnover -NINL Nlp Cell cycle regulation; Microtubule-binding Q9Y2I6 22981 20p11.21 human K495-ub 486278 EKLTLALkENSRLQK protein degradation 17403670 1 0 0 -KHDRBS1 KHDRBS1 RNA-binding Q07666 10657 1p35.2 human R45-m2 476768 PPLPHRSrGGGGGSR intracellular localization 12529443 1 3 0 -XRCC6 Ku70 DNA repair, damage; DNA-binding; EC 3.6.4.-; EC 4.2.99.-; Helicase; Nuclear receptor co-regulator; RNA-binding P12956 2547 22q13.2 human S155-p 21691607 WVCANLFsDVQFKMS Ku_N molecular association, regulation; phosphorylation cell cycle regulation; apoptosis, induced AurB(INDUCES); TRIP12(INDUCES) 22037767; 27849008; 37108203 3 0 0 -P2RY2 P2Y2 GPCR, family 1; Membrane protein, integral; Membrane protein, multi-pass; Receptor, GPCR; Receptor, misc. P41231 5029 11q13.4 human S243-p 2909200 LPRAKRKsVRTIAVV 7tm_1 receptor desensitization, altered; intracellular localization 16311903 2 0 0 -MAP3K5 ASK1 EC 2.7.11.25; KINASE; Kinase, protein; Protein kinase, STE; Protein kinase, Ser/Thr (non-receptor) Q99683 4217 6q23.3 human R89-me 54227301 SSVGGGSrRTTVAYV molecular association, regulation; phosphorylation Akt1(INDUCES) 26912789 1 1 0 methylation of ASK1 at Arg89 promotes the phosphorylation of ASK1 at S83 -PIK3R1 PIK3R1 KINASE; Kinase, lipid; Motility/polarity/chemotaxis P27986 5295 5q13.1 human S154-p 7445250 STLYRTQsSSNLAEL RhoGAP activity, induced; molecular association, regulation; intracellular localization cell motility, inhibited PTEN(INDUCES) 23129748 3 8 0 neutrophil migration regulation -Snap25 SNAP-25 Vesicle P60879 20614 2 F3|2 67.56 cM mouse T138-p 449875 GGFIRRVtNDARENE SNAP-25 molecular association, regulation exocytosis, inhibited STX1A(DISRUPTS) 28486561 7 5 3 -TRIM65 TRIM65 Ubiquitin conjugating system Q6PJ69 201292 17q25.1 human S172-p 1871608300 QSSQIQNsACILASW carcinogenesis, inhibited; signaling pathway regulation 31332286 1 1 0 dephosphorylated form (6A mutant) contributes to TRIM65 function in tumor progression -Nefm NFM Cytoskeletal P08553 18040 14|14 D1 mouse S605-p 451836 EKPEKAKsPMPKSPV cytoskeletal reorganization 19193875 4 20 19 slightly altered axoplasmic organization in 7S/A mice mutant -AMOTL2 AMOTL2 Cell adhesion Q9Y2J4 51421 3q22.2 human Y107-p 15561222 KGEELPTyEEAKAHS molecular association, regulation signaling pathway regulation Src(INDUCES) 21937427 1 1 0 activation of Ras/Raf/Erk pathway -BDKRB2 BKR2 GPCR, family 1; Membrane protein, integral; Membrane protein, multi-pass; Receptor, GPCR P30411 624 14q32.2 human Y177-p 457134 GVRWAKLySLVIWGC 7tm_1; TM activity, induced; phosphorylation 16226010 1 0 1 this increases ERK activation when stimulated with EGF+isoproterenol+bradykinin as compared to the WT BKR2.; Mutation of both tyrosines to phenylalanines prevents Gi protein-mediated cAMP accumulation induced by bradykinin -CTTN Cortactin Actin-binding; Cytoskeletal; Motility/polarity/chemotaxis Q14247 2017 11q13.3 human Y470-p 447703 AYATEAVyESAEAPG molecular association, regulation; receptor recycling, induced cell motility, induced; cell adhesion, altered; cytoskeletal reorganization N-WASP(INDUCES) 15056655; 24188565; 25077552; 29133485; 9748248 32 3 10 invadopodia formation; Tyrosine phosphorylation is necessary for enhanced S1P barrier enhancement. ; ECM invasion as well as transwell and 2D migration; Previous work by the authors showed that src attenuates the actin cross-linking activity of cortactin. These studies show that transfection with a cortactin mutant (F421/F470/F486) impairs the motility of endothelial cells. -MAPKAP1 Sin1 Adaptor/scaffold Q9BPZ7 79109 9q33.3 human S128-p 3830292 KSLFEKKsLKEKPPI SIN1 intracellular localization signaling pathway regulation 30837283 1 0 22 -BAK1 BAK1 Apoptosis; Endoplasmic reticulum; Membrane protein, integral; Mitochondrial Q16611 578 6p21.31 human Y108-p 15794303 QPTAENAyEYFTKIA Bcl-2 protein conformation; activity, inhibited apoptosis, altered; apoptosis, inhibited 20959805; 25649765 3 1 0 -PAPOLA PAP-alpha EC 2.7.7.19; RNA processing; RNA splicing; Transferase P51003 10914 14q32.2 human K740-ac 483064 PVIKNSIkLRLNR__ protein stabilization; molecular association, regulation; enzymatic activity, inhibited; intracellular localization CPSF6(DISRUPTS); CFIM25(DISRUPTS) 17172643; 18281463 2 1 0 -TRIP10 TRIP10 iso3 Adaptor/scaffold; Motility/polarity/chemotaxis; Nuclear receptor co-regulator Q15642-3 9322 19p13.3 human Y471-p 480709 ESQDTPIyTEFDEDF intracellular localization carcinogenesis, altered; cytoskeletal reorganization 21525036 1 0 2 alters TRIP10 invadopodia-suppressive activity -TP63 p63 DNA-binding; Transcription factor Q9H3D4 8626 3q28 human K676-sm 3617601 RNKQQRIkEEGE___ protein degradation transcription, inhibited 15611636 2 0 0 -STAT6 STAT6 DNA-binding; Transcription factor P42226 6778 12q13.3 human S407-p 21561700 PIQLQALsLPLVVIV STAT_bind molecular association, regulation; intracellular localization; phosphorylation transcription, induced; signaling pathway regulation STAT6(INDUCES) 22000020 1 0 0 induces phosphorylation of Y641 and regulates cytokine signaling -UHRF1 UHRF1 DNA-binding; EC 6.3.2.-; EC 6.3.2.19; Ligase; Transcription factor; UBIQUITIN LIGASE; Ubiquitin conjugating system; Ubiquitin ligase Q96T88 29128 19p13.3 human S298-p 2902206 DNPMRRKsGPSCKHC molecular association, regulation; protein conformation cell cycle regulation ATRX(INDUCES); UHRF1(DISRUPTS) 32428527 3 1 0 interaction with apo-TTD and the linker domain disrupted -MAPK3 ERK1 EC 2.7.11.24; KINASE; Kinase, protein; Protein kinase, CMGC; Protein kinase, Ser/Thr (non-receptor) P27361 5595 16p11.2 human T207-p 3949243 FLTEYVAtRWYRAPE Pkinase enzymatic activity, inhibited 26823016 2 13 31 -TTK TTK Cancer Testis Antigen (CTA); EC 2.7.12.1; KINASE; Kinase, protein; Protein kinase, Other; Protein kinase, dual-specificity (non-receptor) P33981 7272 6q14.1 human T12-p 13194901 DLSGRELtIDSIMNK intracellular localization; enzymatic activity, induced cell cycle regulation 18923149; 25265012; 26119734; 36395767 6 2 1 autophosphorylation of this site is required for release TTK from kinetochore; causes decreased kinetochore localization of BubR1 and Mad2. -TERF2 TRF2 DNA repair, damage; DNA-binding Q15554 7014 16q22.1 human R59-me 10338216 GSGRAAGrRASRSSG cell cycle regulation; cell growth, altered 19596784 1 0 0 -EPHA3 EphA3 EC 2.7.10.1; KINASE; Kinase, protein; Membrane protein, integral; Protein kinase, TK; Protein kinase, tyrosine (receptor) P29320 2042 3p11.1 human Y602-p 449913 TYVDPHTyEDPTQAV EphA2_TM molecular association, regulation; enzymatic activity, induced cytoskeletal reorganization; cell adhesion, altered CRK(INDUCES) 11870224; 18547520 3 6 31 -CAB2 CACNB2 Channel, calcium P54288 100009277 rabbit S522-p 486359 SGTSRGLsRQETFDS activity, inhibited 17626895; 20937253 3 2 5 -RUNX2 AML3 DNA-binding; Transcription factor Q13950 860 6p21.1 human S196-p 27728401 GRSGRGKsFTLTITV Runt molecular association, regulation transcription, induced DNA(INDUCES) 23389849 1 0 0 induction of MMP3 and MMP9 transcription, invasion of breast cancer cells -LRRK2 LRRK2 EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, Ser/Thr (non-receptor); Protein kinase, TKL Q5S007 120892 12q12 human T1491-p 10426326 DYHFVNAtEESDALA molecular association, regulation TUBB(DISRUPTS) 24275654 10 5 0 -CRMP1 CRMP-1 Cell development/differentiation; Cytoskeletal; Hydrolase Q14194 1400 4p16.2 human T509-p 454314 PVYEVPAtPKYATPA cytoskeletal reorganization 18003833 6 18 7 Phosphorylation induces increased density of synaptic clusters and neurite projection. -IRF7 IRF7 DNA-binding; Transcription factor Q92985 3665 11p15.5 human K92-ac 458962 TAERAGWkTNFRCAL IRF molecular association, regulation DNA(DISRUPTS) 12374802 1 0 0 -Mcm3 MCM3 DNA replication; EC 3.6.4.12 P25206 17215 1|1 A4 mouse S725-p 475061 HTPKTDDsQEKTDDS intracellular localization 17244605 1 4 0 Preferentially localized to the soluble nucleoplasmic fraction. -Notch1 Notch 1 Membrane protein, integral; Motility/polarity/chemotaxis; Oncoprotein; Receptor, misc.; Transcription factor Q01705 18128 2 A3|2 18.91 cM mouse R2303-m2 56852200 GQCEWLPrLQNGMVP activity, induced; protein degradation; ubiquitination transcription, induced 25805888 1 1 0 -Tardbp TDP-43 RNA-binding Q921F2 230908 4|4 E2 mouse S409-p 3084616 GSSMDSKsSGWGM__ ubiquitination apoptosis, induced DROSHA(DISRUPTS); hnRNP P2(DISRUPTS) 23840565; 26102026 54 4 0 Phosphorylated, ubiqitinated protein forms insoluble aggregates.; disrupts interaction between Drosha and FUS -TFEB TFEB DNA-binding; Transcription factor P19484 7942 6p21.1 human S211-p 25529700 LVGVTSSsCPADLTQ activity, induced; molecular association, regulation; intracellular localization; activity, inhibited; phosphorylation carcinogenesis, induced; exocytosis, induced; cell motility, induced; apoptosis, inhibited; autophagy, inhibited; transcription, inhibited; cell growth, altered 14-3-3 beta(INDUCES); mTOR(INDUCES); 14-3-3 theta(INDUCES); 14-3-3 zeta(INDUCES); 14-3-3 epsilon(INDUCES); 14-3-3 gamma(INDUCES); CHIP(INDUCES) 22576015; 22692423; 25561726; 26813791; 28055300; 28754656; 29507340; 29945972; 34405859; 35020443; 36436593; 36970883 22 3 0 -Dmd dystrophin Cytoskeletal; Motility/polarity/chemotaxis P11531 13405 X C1|X 38.38 cM mouse S3059-p 35542205 GPWERAIsPNKVPYY WW molecular association, regulation DAG1(INDUCES) 33729835 2 1 0 regulates protection against inflammation-induced muscle wasting -ARHGDIB RhoGDI beta Cell adhesion; G protein regulator, misc.; Motility/polarity/chemotaxis P52566 397 12p12.3 human S31-p 4933709 YKPPPQKsLKELQEM Rho_GDI molecular association, regulation; activity, inhibited CDC42(DISRUPTS); RAC1(DISRUPTS) 22469974; 31075185 2 2 34 -Gsk3b GSK3B EC 2.7.11.1; EC 2.7.11.26; KINASE; Kinase, protein; Protein kinase, CMGC; Protein kinase, Ser/Thr (non-receptor) P18266 84027 11q21 rat K205-ac 27738300 LCDFGSAkQLVRGEP Pkinase transcription, induced 23292070 2 0 0 -Nlrp3 NLRP3 Inhibitor Q8R4B8 216799 11|11 B1.3 mouse S803-p 1877558200 KLVELDLsDNALGDF LRR_6 molecular association, regulation NEK7(DISRUPTS); PYCARD(DISRUPTS) 34615873 1 1 0 -FUS hnRNP P2 DNA-binding; Nuclear receptor co-regulator; Oncoprotein; RNA splicing; RNA-binding; SUMO LIGASE P35637 2521 16p11.2 human K510-ac 36293641 RGGFGPGkMDSRGEH molecular association, regulation; intracellular localization KPNB2(DISRUPTS) 32691043 1 2 2 formation of stress granule-like inclusions -YAP1 YAP1 Oncoprotein; Transcription, coactivator/corepressor P46937 10413 11q22.1 human K494-ub 1880099301 ESVLAATkLDKESFL protein degradation carcinogenesis, altered 36271031 1 0 0 -Irs1 IRS1 Adaptor/scaffold; Motility/polarity/chemotaxis P35570 25467 9q34 rat S635-p 447507 YMPMSPKsVSAPQQI molecular association, regulation PIK3R1(DISRUPTS) 16354680 35 4 0 -BCL2L11 BIM Apoptosis O43521 10018 2q13 human S69-p 449330 GPLAPPAsPGPFATR protein degradation; molecular association, regulation apoptosis, altered; apoptosis, inhibited; cell adhesion, altered; transcription, altered Bcl-xL(DISRUPTS); MCL1(DISRUPTS) 14555991; 15486195; 17525735; 18246127; 25915848 23 1 1 tyrosine kinase inhibitor resistance -RPS6KA5 MSK1 EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, AGC; Protein kinase, Ser/Thr (non-receptor) O75582 9252 14q32.11 human S212-p 448214 DETERAYsFCGTIEY Pkinase enzymatic activity, induced 15568999 2 6 9 -AMPH amphiphysin Vesicle P49418 273 7p14.1 human T350-p 469996 PEVKKEEtLLDLDFD molecular association, regulation CLTC(DISRUPTS) 16945112 1 0 0 -Panx3 PANX3 Cell adhesion; Membrane protein, integral; Membrane protein, multi-pass Q8CEG0 208098 9|9 A4 mouse S68-p 1869686803 GSPISCFsPSNFSVR Innexin activity, induced; intracellular localization; protein conformation cell differentiation, induced; signaling pathway regulation 31822768 1 0 0 osteoblast differentiation -Rag1 RAG1 DNA-binding; EC 3.1.-.-; EC 6.3.2.-; EC 6.3.2.19; Ligase; UBIQUITIN LIGASE; Ubiquitin conjugating system; Ubiquitin ligase P15919 19373 2 E2|2 53.88 cM mouse S528-p 28076402 PPLKNVSsRTDVGII RAG1 activity, induced 23716691 1 0 0 Phosphorylation at S528 activates V(D)J recombination. -Wasl N-WASP Adaptor/scaffold; Motility/polarity/chemotaxis Q91YD9 73178 6|6 A3.1 mouse Y253-p 450253 RETSKVIyDFIEKTG PBD activity, induced; molecular association, regulation; intracellular localization cytoskeletal reorganization KPNA1(DISRUPTS) 14676198; 24223520 9 65 1373 -Hspb1 HSP27 Chaperone; Heat shock protein; Motility/polarity/chemotaxis; SUMO LIGASE; SUMO ligase P42930 24471 12q12 rat S86-p 448403 RALNRQLsSGVSEIR intracellular localization; enzymatic activity, induced cytoskeletal reorganization 24914207; 33557752; 36260112 78 104 289 Actin polymerization induced -URI1 RMP Transcription, coactivator/corepressor O94763 8725 19q12 human S372-p 1028301 AKRKRKNsTGSGHSA O-GlcNAc glycosylation; molecular association, regulation; phosphorylation carcinogenesis, inhibited; cell growth, inhibited; apoptosis, induced; apoptosis, inhibited; signaling pathway regulation PPP1CC(DISRUPTS) 17936702; 21397856; 27505673 3 23 16 increased S372 phosphorylation induces disruption of complexes ; inhibits S6K1 and BAD phosphorylation, regulates S6K1/BAD signaling pathway; S372 phosphorylation inversely correlated with O-GlcNAcylation -DRD3 DRD3 GPCR, family 1; Membrane protein, integral; Membrane protein, multi-pass; Receptor, GPCR P35462 1814 3q13.31 human T142-p 1184590200 PVHYQHGtGQSSCRR 7tm_1 protein degradation; molecular association, regulation endocytosis, induced GRK2(DISRUPTS) 29885323 1 0 0 inhibits receptor signaling -PRKCD PKCD EC 2.7.11.13; KINASE; Kinase, protein; Nuclear receptor co-regulator; Protein kinase, AGC; Protein kinase, Ser/Thr (non-receptor); Protein kinase, tyrosine (non-receptor); Tumor suppressor Q05655 5580 3p21.1 human Y334-p 450077 MQDNSGTyGKIWEGS molecular association, regulation; enzymatic activity, induced apoptosis, induced Src(INDUCES) 17658731; 28784722 13 25 532 Y334 phosphorylation increases clevage of PKCD into active catalytic domain. ; DKD-507A activity activity is rescued by Src-dependent Y334 phosphorylation -FNIP1 FNIP1 Q8TF40 96459 5q31.1 human S946-p 4734332 SDSALGDsESEDTGH protein stabilization; molecular association, regulation signaling pathway regulation HSP90A(INDUCES) DNA(INDUCES) 30699359 1 10 0 -RECQL4 RECQL4 EC 3.6.4.12; Helicase O94761 9401 8q24.3 human T139-p 1869193203 RASSKAStPKPPGTG molecular association, regulation WDHD1(INDUCES); GINS4(INDUCES) 31519754 1 0 0 induces activation of replication origin -NOX5 NOX5 EC 1.6.3.-; Membrane protein, integral; Membrane protein, multi-pass; Oxidoreductase Q96PH1 79400 15q23 human Y476-p 1869973807 FHYRPGDyLYLNIPT FAD_binding_8 signaling pathway regulation 32792487 1 0 0 activation of Src, Pyk2-mediated phosphorylation of Nox5 -PCNT PCNT Cell cycle regulation O95613 5116 21q22.3 human S1235-p 25617500 MSSVAEIsSHMRESF cytoskeletal reorganization 22184200; 24466316 2 0 0 important for spindle formation and centrosomal microtubule nucleation and the recruitment of the PCM proteins for centrosome maturation in mitosis; centrosome maturation and bipolar spindle formation during mitosis -TRPV5 TRPV5 Channel, cation; Membrane protein, integral; Membrane protein, multi-pass; Motility/polarity/chemotaxis Q9NQA5 56302 7q34 human S144-p 27115700 LTRRASVsARATGTA Ank_2 activity, inhibited 23024298 1 0 0 S144 phosphorylation is necessary for plasmin inhibition of channel Ca++ currents. -RIPK3 RIPK3 EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, Ser/Thr (non-receptor); Protein kinase, TKL Q9Y572 11035 14q12 human S227-p 23003800 VELPTEPsLVYEAVC Pkinase molecular association, regulation; phosphorylation signaling pathway regulation MLKL(INDUCES) 22265413; 29883609; 35256774; 35739084 25 7 0 induces necrosis through the necrosis pathway -tpx2.L TPX2 Cell cycle regulation; Microtubule-binding Q6NUF4 398174 frog S291-p 31890658 KRKHEEAsDYVSTAE intracellular localization KPNB1(INDUCES) 29276125 1 1 0 accumulation of TPX2 at the prophase centrosome -MCL1 MCL1 Apoptosis; Channel, misc.; Inhibitor; Membrane protein, integral; Mitochondrial Q07820 4170 1q21.2 human K194-ub 10837355 REQATGAkDTKPMGR protein degradation 28522751 4 5 33 -PPP1R15A GADD34 Apoptosis; Cell cycle regulation; DNA repair, damage; Protein phosphatase, regulatory subunit; Translation initiation O75807 23645 19q13.33 human Y262-p 478288 SDPRSWEyRSGEASE protein degradation; phosphorylation apoptosis, induced; signaling pathway regulation 24092754 1 1 0 modulates endoplasmic reticulum stress signaling; inhibits EIF2 dephosphorylation -CASP7 CASP7 Apoptosis; EC 3.4.22.60; Endoplasmic reticulum; Mitochondrial; Protease P55210 840 10q25.3 human S239-p 20473607 WRSPGRGsWFVQALC Peptidase_C14 enzymatic activity, inhibited; activity, inhibited cell growth, induced; apoptosis, inhibited 21555521; 27889207 2 0 0 -CENPQ CENPQ Q7L2Z9 55166 6p12.3 human S249-p 3850352 LDILHNSsQMKSMST CENP-Q molecular association, regulation; intracellular localization DNA(DISRUPTS) 25670858 1 7 5 CENPQ phosphorylation promotes the delocalization of the PBIP1-CENPQ complex from kinetochores -KNL1 CASC5 Cancer Testis Antigen (CTA); Cell cycle regulation Q8NG31 57082 15q15.1 human S24-p 3829218 RPVRRRHsSILKPPR phosphorylation cell cycle regulation 25402682 4 3 7 -PCSK9 PCSK9 Cell development/differentiation; EC 3.4.21.-; Protease; Secreted; Secreted, signal peptide Q8NBP7 255738 1p32.3 human S47-p 2811403 ELVLALRsEEDGLAE activity, induced; protein degradation; protein processing exocytosis, induced 18498363; 31553664 2 5 0 stabilizes against cleavage of propeptide; LDL-receptor activity induced, LDLR degradation -Btg2 BTG2 Transcription factor Q04211 12227 1 E4|1 58.1 cM mouse S147-p 455911 QMMLGRSsPSKNYVM molecular association, regulation PIN1(INDUCES) 15788397 1 0 0 -MAVS MAVS Adaptor/scaffold; Membrane protein, integral Q7Z434 57506 20p13 human S330-gl 1872691000 PSKLPTSsKPPGAVP phosphorylation 31461653 1 1 0 positively regulates phosphorylation of S442 (data from MAVS 7A mutant) -SENP2 SENP2 DESUMOYLASE; EC 3.4.22.68; Protease; Sumo-specific protease Q9HC62 59343 3q27.2 human K447-sm 1878219601 TFFYPKLkSGGYQAV ubiquitination; activity, inhibited 31266997 1 0 0 LMP1 inhibited the ubiquitination of SENP2 -Klc1 KLC1 Microtubule-binding; Motor O88447 16593 12 F1|12 61.13 cM mouse T465-p 4948487 DSPTVTTtLKNLGAL TPR_10 molecular association, regulation JIP1(DISRUPTS) 29093025 1 2 0 regulates the velocity of transport of APP by kinesin-1 by modulating its interaction with JIP1 -PCNA PCNA Cell cycle regulation; DNA replication P12004 5111 20p12.3 human K248-me 1872852100 IADMGHLkYYLAPKI PCNA_C protein stabilization; molecular association, regulation; ubiquitination cell cycle regulation; carcinogenesis, induced; DNA repair, induced; cell growth, induced FEN1(INDUCES) 22556262 1 0 0 inhibits ubiquitination, regulates DNA replication -KAT5 Tip60 ACETYLTRANSFERASE; Acetyltransferase; EC 2.3.1.48; Nuclear receptor co-regulator; Nucleolus Q92993 10524 11q13.1 human K451-sm 1968601 ISEITSIkKEDVIST MOZ_SAS intracellular localization; enzymatic activity, induced DNA repair, induced 17704809 1 0 0 -BRIP1 BRIP1 EC 3.6.4.13; Helicase; Oncoprotein Q9BX63 83990 17q23.2 human T1133-p 5831623 EDESIYFtPELYDPE molecular association, regulation cell cycle regulation TOPBP1(INDUCES) 20159562 1 0 1 -NUMA1 NuMA-1 Cell cycle regulation; Motility/polarity/chemotaxis Q14980 4926 11q13.4 human S1883-p 31033004 YRPTTRSsARRSQAG cell growth, induced; apoptosis, inhibited 23097092 1 1 0 cell proliferation increased -DYRK4 DYRK4 EC 2.7.12.1; KINASE; Kinase, protein; Protein kinase, CMGC; Protein kinase, dual-specificity (non-receptor) Q9NR20 8798 12p13.32 human Y264-p 454665 EHQKVYTyIQSRFYR Pkinase phosphorylation; enzymatic activity, induced 21127067 1 40 1593 Peptide 285 phosphorylation -RAD52 RAD52 DNA repair, damage P43351 5893 12p13.33 human K412-sm 13258712 RKSQDMKkRKYDPS_ intracellular localization 20190268 1 1 0 -CDC6 CDC6 Cell cycle regulation Q99741 990 17q21.2 human K109-ac 8539500 LTIKSPSkRELAKVH intracellular localization cell cycle regulation 19343071 1 0 0 -NDEL1 NDEL1 Microtubule-binding; Protease Q9GZM8 81565 17p13.1 human S242-p 3685801 IPNGFGTsPLTPSAR NUDE_C molecular association, regulation; intracellular localization PAFAH1B1(INDUCES); DYNC1I1(INDUCES) 12556484; 37086789 3 4 1 -BRCA1 BRCA1 EC 6.3.2.-; Nuclear receptor co-regulator; Transcription, coactivator/corepressor; Tumor suppressor; UBIQUITIN LIGASE; Ubiquitin conjugating system; Ubiquitin ligase P38398 672 17q21.31 human S1387-p 455495 EDCSGLSsQSDILTT cell cycle regulation; DNA repair, altered 12183412; 25939603; 26320175; 34301763 9 0 0 -Nfatc2 NFAT1 DNA-binding; Transcription factor Q60591 18019 2 H3|2 88.91 cM mouse S270-p 447849 VAPLPAAsPQRSRSP transcription, inhibited 11030334 0 12 0 -MAP3K5 ASK1 EC 2.7.11.25; KINASE; Kinase, protein; Protein kinase, STE; Protein kinase, Ser/Thr (non-receptor) Q99683 4217 6q23.3 human K535-sm 12004432 TTEQPVAkQELVDFW MAP3K_TRAF_bd molecular association, regulation apoptosis, inhibited ASK1(DISRUPTS); SUMO1(INDUCES) 16142216 1 0 0 ASK1 is not sumoylated but SUMO1 interaction inhibits the oligomerization of ASK1 -GPR15 GPR15 GPCR, family 1; Membrane protein, integral; Membrane protein, multi-pass; Receptor, GPCR P49685 2838 3q11.2 human S359-p 17737600 RRRKRSVsL______ molecular association, regulation; protein processing; intracellular localization 14-3-3 beta(INDUCES); COPB1(DISRUPTS) 21189250 2 0 0 -Plin1 perilipin 1 Lipid-binding Q8CGN5 103968 7|7 D2 mouse S276-p 450081 QVVSRRQsEVRVPWL Perilipin molecular association, regulation HSL(INDUCES) 19717842 2 1 0 -Ctnnb1 CTNNB1 Actin-binding; Cell adhesion; Motility/polarity/chemotaxis; Nuclear receptor co-regulator; Oncoprotein; Transcription factor Q9WU82 84353 8q32 rat Y654-p 447585 RNEGVATyAAAVLFR intracellular localization 12123611; 33660049 32 2 20 regulates dissociation of adherent junctions -EGR1 EGR1 C2H2-type zinc finger protein; DNA-binding; Transcription factor P18146 1958 5q31.2 human S378-p 11421601 RICMRNFsRSDHLTT zf-C2H2 transcription, altered DNA(DISRUPTS) 8662759 1 0 0 -XRCC1 XRCC1 DNA repair, damage P18887 7515 19q13.31 human K260-ac 466090 EEKKTPSkPPAQLSP protein degradation 31043584 1 1 2 -CDKN1A p21Cip1 Cell cycle regulation; Inhibitor P38936 1026 6p21.2 human S153-p 456134 SMTDFYHsKRRLIFS molecular association, regulation; intracellular localization Calmodulin(DISRUPTS) 15851482; 16055744 2 1 0 S152 D mutation inhibts binding of CaM to p21. S152D disrupted stress fibers. Phosphorylation at S152 did not affect p21 binding to PCNA. ; Mutation GFP S152D showed an increase in cytoplasmic localization. S152D mutation showed decreased nuclear localization in both COS and NIH 3T3 cells in comparison to wild-type. -GATA1 GATA1 DNA-binding; Transcription factor P17678 396450 chicken K214-ac 459195 GIQTRNRkVSSKGKK molecular association, regulation; protein conformation cell differentiation, induced; transcription, induced DNA(INDUCES) 9859997 2 1 0 -MAD1L1 MAD1L1 Cell cycle regulation; Cytoskeletal Q9Y6D9 8379 7p22.3 human S610-p 334535801 ELKKQVEsAELKNQR MAD molecular association, regulation cell cycle regulation Mad2(INDUCES) 29162720 1 0 0 -GOLPH3 GOLPH3 Mitochondrial Q9H4A6 64083 5p13.3 human T148-p 31834910 KETQPPEtVQNWIEL GPP34 activity, induced; molecular association, regulation DNA repair, induced; signaling pathway regulation MYO18A(INDUCES) 24485452 1 1 0 DNA-PK/GOLPH3/MYO18A pathway, Increased phosphorylation leads to DNA-damage-induced Golgi dispersion -Pik3ap1 BCAP Adaptor/scaffold Q9EQ32 83490 19|19 C3 mouse Y445-p 448184 PGCDDELyESMAAFA molecular association, regulation cell differentiation, altered PIK3R1(INDUCES) 18025150 2 0 0 regulate Akt activation and B-cell differentiation through binding to PI3KR1 -MTOR mTOR Autophagy; EC 2.7.11.1; KINASE; Kinase, protein; Motility/polarity/chemotaxis; Protein kinase, Ser/Thr (non-receptor); Protein kinase, atypical P42345 2475 1p36.22 human S1415-p 25745815 PTPAILEsLISINNK molecular association, regulation; phosphorylation; enzymatic activity, induced carcinogenesis, induced; cell growth, induced Raptor(DISRUPTS) 24990947 1 1 1 Induce phosphorylation of S6K -ARID4B ARID4B DNA-binding Q4LE39 51742 1q42.3 human K429-sm 12004427 NVKEIKVkEENETEI cell cycle regulation; cell growth, inhibited; transcription, inhibited 16479010 1 2 0 -PIP4K2A PIP4K2A Carbohydrate Metabolism - inositol phosphate; EC 2.7.1.149; Kinase, lipid; Motility/polarity/chemotaxis P48426 5305 10p12.2 human S304-p 450664 DGEEEGEsDGTHPVG PIP5K intracellular localization 10508590 1 0 0 -MEF2B MEF2B iso2 DNA-binding; Transcription factor Q02080-2 100271849 19p13.11 human K319-sm 29649501 PTPPVSIkSERLSPA transcription, inhibited 23974956 1 0 0 Phosphorylation-dependent sumoylation inhibited transcription. -RPTOR Raptor Adaptor/scaffold Q8N122 57521 17q25.3 human S877-p 3205938 HIHQAGGsPPASSTS enzymatic activity, inhibited cell cycle regulation 21900751; 31530866 8 54 0 -Dpysl5 CRMP-5 Q9EQF6 65254 5|5 B1 mouse S534-p 478229 DLHESSFsLSGSQID phosphorylation 29758318 1 6 2 S522A KI mice -Hcn2 HCN2 Channel, cation; Membrane protein, integral; Membrane protein, multi-pass O88703 15166 10|10 C1 mouse Y476-p 457528 FRQKIHDyYEHRYQG activity, induced 16079136 1 1 0 Y476F mutation in Hcn2 and Y554F mutation in Hcn4, abolishes the effect of PP2 on activation. -PDCD4 PDCD4 Apoptosis; Tumor suppressor Q53EL6 27250 10q25.2 human S457-p 458382 RGRKRFVsEGDGGRL protein degradation; molecular association, regulation; ubiquitination; intracellular localization cell motility, induced; cell growth, induced 14-3-3 beta(INDUCES) 16357133; 20661426; 25002506; 27028868 8 74 46 -N Nucleocapsid Protein P59595 1489678 SARSCoV1 S207-p 1868174933 PGSSRGNsPARMASG CoV_nucleocap molecular association, regulation Nucleocapsid Protein(INDUCES) 23717688 4 5 0 di-domain self-association -Ptprr PTP-SL iso2 EC 3.1.3.48; Membrane protein, integral; Motility/polarity/chemotaxis; PHOSPHATASE; Receptor protein phosphatase, tyrosine Q62132-2 19279 10|10 D2 mouse S231-p 31949800 GLQERRGsNVSLTLD intracellular localization; enzymatic activity, inhibited transcription, induced; signaling pathway regulation 24497609 1 0 0 phosphorylation of PTP-SL at S231 induces nuclear localization of MAPK. -PKP2 plakophilin 2 Cell adhesion; Membrane protein, integral; Motility/polarity/chemotaxis Q99959 5318 12p11.21 human S82-p 468460 GNLHRTSsVPEYVYN molecular association, regulation; intracellular localization 14-3-3 beta(INDUCES) 12941695 1 23 109 -DVL2 DVL2 Adaptor/scaffold; Motility/polarity/chemotaxis O14641 1856 17p13.1 human Y275-p 12170305 VTLNMEKyNFLGISI PDZ transcription, induced 19920076 1 2 1 regulates Wnt3a/beta-catenin signaling -ATF2 ATF-2 ACETYLTRANSFERASE; C2H2-type zinc finger protein; EC 2.3.1.48; Transcription factor P15336 1386 2q31.1 human S490-p 455782 QSTEPALsQIVMAPS intracellular localization 15916964 1 0 0 S472/480 are important for ionizing radiation-induced S phase checkpoint control -CGAS cGAS EC 2.7.7.86 Q8N884 115004 6q13 human K479-sm 59117702 LQCLRTEkLENYFIP Mab-21_C activity, induced; protein stabilization 27637147 1 0 0 regulates the stability of activated cGas -SUPT16H SPT16 Transcription initiation complex Q9Y5B9 11198 14q11.2 human K674-ub 22252789 IRPNIAQkRMQGSLE SPT16 molecular association, regulation cell cycle regulation; chromatin organization, altered H3(DISRUPTS); H4(DISRUPTS) 35320725 1 3 0 K674 ubiquitylation of SPT16 regulates DNA replication-coupled histone incorporation into chromatin -PI4KB PIK4CB iso2 Carbohydrate Metabolism - inositol phosphate; EC 2.7.1.67; Kinase, lipid; Motility/polarity/chemotaxis Q9UBF8-2 5298 1q21.3 human S294-p 457621 SNLKRTAsNPKVENE molecular association, regulation; intracellular localization; enzymatic activity, induced 14-3-3 theta(INDUCES); 14-3-3 zeta(INDUCES); 14-3-3 gamma(INDUCES) 16100512; 16606619; 16912074 7 38 9 S294 phosphorylated PIK4CB localizes in Golgi structures; interaction with 14-3-3 protects PIK4CB against dephosphorylation -Dcx Doublecortin iso3 Cytoskeletal; Motility/polarity/chemotaxis Q9CXL6 13193 X|X F2 mouse S47-p 451112 TRTLQALsNEKKAKK cytoskeletal reorganization 33405953 5 0 0 -MCAM MCAM Cell adhesion; Membrane protein, integral NP_001004768 448832 chicken S594-p 1243502 KNVVEVKsDKLSEEA cytoskeletal reorganization 17982057 1 8 0 -AKTIP AKTIP Apoptosis; Membrane protein, peripheral; Vesicle Q9H8T0 64400 16q12.2 human T22-p 1876861200 RSEGEEKtLTGDVKT phosphorylation carcinogenesis, induced; cell growth, induced 35366279 1 1 0 -Tp63 p63 DNA-binding; Transcription factor O88898 22061 16 B1|16 17.37 cM mouse T522-p 20506702 DMNGLSPtQALPPPL activity, induced 21325887 1 0 0 -FEN1 FEN1 DNA repair, damage; DNA-binding; Deoxyribonuclease; EC 3.1.-.-; Nuclear receptor co-regulator; Nucleolus; Ribonuclease P39748 2237 11q12.2 human K354-ac 458855 TGSLSSAkRKEPEPK molecular association, regulation; enzymatic activity, inhibited DNA(DISRUPTS) 11430825 1 2 0 -Bcl11b Bcl-11B C2H2-type zinc finger protein; Nuclear receptor co-regulator; Transcription regulation Q99PV8 58208 12 F1|12 59.1 cM mouse S664-p 14159422 RKPAPLPsPGLGGPA molecular association, regulation SENP1(INDUCES) 22700985 0 7 0 -Irs2 IRS2 Adaptor/scaffold; Motility/polarity/chemotaxis P81122 384783 8 A1.1|8 5.35 cM mouse Y628-p 457098 YNPYPEDyGDIEIGS molecular association, regulation INSR(DISRUPTS) 9195949 2 13 40 -Slc24a2 SLC24A2 Membrane protein, integral; Membrane protein, multi-pass; Transporter; Transporter, SLC family O54701 84550 5q32 rat Y365-p 3721716 LAEELGSyGKLKYYD molecular association, regulation endocytosis, inhibited AP2M1(INDUCES) 23431067 1 0 0 -Eef2 EEF2 Translation; Translation elongation P05197 29565 7q11 rat T57-p 448040 RAGETRFtDTRKDEQ GTP_EFTU activity, inhibited 12194824 39 61 54 Phosphorylation of T56 correlates with inhibition of protein synthesis. -Nfatc2 NFAT1 DNA-binding; Transcription factor Q60591 18019 2 H3|2 88.91 cM mouse S136-p 449623 RGRDAGLsPEQPALA transcription, inhibited 11030334 0 13 0 -Nfkbib IkB-beta Inhibitor Q9JIA3 81525 1q21 rat Y161-p 457691 PRDASDTyLTQSQDH molecular association, regulation apoptosis, induced NFkB-p65(INDUCES) 16286457 1 1 1 -STIL STIL Cell cycle regulation; Cell development/differentiation; Oncoprotein Q15468 6491 1p33 human S428-p 1868450205 QPSVPELsLVLDGNF STIL_N molecular association, regulation; intracellular localization cell cycle regulation; cytoskeletal reorganization CENPJ(INDUCES) 31115335 1 1 0 -MLKL MLKL KINASE; Kinase, protein; Protein kinase, Ser/Thr (non-receptor); Protein kinase, TKL Q8NB16 197259 16q23.1 human T357-p 5891858 FELRKTQtSMSLGTT PK_Tyr_Ser-Thr molecular association, regulation; intracellular localization; protein conformation apoptosis, induced; signaling pathway regulation MLKL(INDUCES) 22265413; 24703947; 26184911; 28758999 7 1 1 induces through the necrosis pathway; oligomer formation during necrosis, binds membrane lipids -ULK1 ULK1 Autophagy; EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, Other; Protein kinase, Ser/Thr (non-receptor) O75385 8408 12q24.33 human S638-p 3176158 FDFPKTPsSQNLLAL enzymatic activity, inhibited; enzymatic activity, induced; phosphorylation autophagy, induced; carcinogenesis, inhibited; autophagy, inhibited; autophagy, altered 21383122; 30093610; 35670018 4 35 41 -RELA NFkB-p65 DNA-binding; Nuclear receptor co-regulator; Transcription factor Q04206 5970 11q13.1 human S205-p 1295501 RVNRNSGsCLGGDEI RHD_dimer molecular association, regulation; intracellular localization transcription, induced; transcription, altered DNA(INDUCES) 15516339; 17991436; 18025230; 23100252 4 1 0 -Myrf MRF DNA-binding; Membrane protein, integral Q3UR85 225908 19|19 A mouse S142-p 20804936 LPDSPPDsGSEAYSP protein degradation; ubiquitination 29472293 1 1 0 -RICTOR RICTOR Adaptor/scaffold; Cell cycle regulation; Ubiquitin conjugating system Q6R327 253260 5p13.1 human T1695-p 40638601 EAEAVLAtPPKQPIV protein degradation; ubiquitination 25897075 1 0 0 -JAM3 JAM3 Cell adhesion; Membrane protein, integral Q9BX67 83700 11q25 human K283-ub 22246354 KQDGESYkNPGKPDG protein degradation; receptor recycling, altered cell motility, induced 31790392 1 3 0 -NEDD9 Cas-L Adaptor/scaffold; Motility/polarity/chemotaxis Q14511 4739 6p24.2 human S296-p 4696722 PVARRHQsLSPNHPP molecular association, regulation AurA(DISRUPTS) 16184168 2 1 3 -Dusp6 DUSP6 EC 3.1.3.16; EC 3.1.3.48; Motility/polarity/chemotaxis; PHOSPHATASE; Protein phosphatase, dual-specificity Q64346 116663 7q13 rat S197-p 455266 SATDSDGsPLSNSQP protein degradation transcription, induced 29375309 5 0 0 -Fmr1 FMR1 Nucleolus; RNA-binding; Translation P35922 14265 X A7.1|X 34.83 cM mouse R545-me 4046001 RGQGGRGrGGGFKGN FXMRP1_C_core molecular association, regulation RNA(DISRUPTS) 20064924 5 0 0 methylation inhibits sc1 RNA binding; R533 and R538 determine association with polyribosomes; methylation doesnot inhibit AATYK mRNA association; different RNAs have distinct molecular requirements for binding to FMR1 -POU4F1 POU4F1 Cell development/differentiation; DNA-binding; Transcription factor Q01851 5457 13q31.1 human S122-p 6311910 DLLDHISsPSLALMA activity, induced cell differentiation, altered; cell differentiation, induced; transcription, induced 16126301; 19135033 2 0 0 activation of galanin promoter induced by retinoic acid -ARHGDIA RhoGDI alpha Apoptosis; Cell adhesion; Cell development/differentiation; G protein regulator, misc.; Motility/polarity/chemotaxis P52565 396 17q25.3 human S174-p 452196 KGMLARGsYSIKSRF Rho_GDI activity, induced; molecular association, regulation; enzymatic activity, induced exocytosis, induced; transcription, altered CDC42(DISRUPTS); RHOA(DISRUPTS); RAC1(DISRUPTS); CDC42 iso1(DISRUPTS) 18768928; 20028975; 29873699; 32003021 7 1 0 RhoA activation; RhoGTPase activation, induces insulin secretion -Nos3 eNOS Amino Acid Metabolism - arginine and proline; EC 1.14.13.39; Oxidoreductase Q62600 24600 4q11 rat S1176-p 447884 TSRIRTQsFSLQERQ activity, induced; enzymatic activity, induced signaling pathway regulation 10025949; 20096547; 25402275; 33772737; 35954193; 36345832 217 18 7 quercetin and myricetin-induced cardioprtection signaling; NO/cGMP signaling -SCARA3 CSR Membrane protein, integral; Receptor, misc. Q6AZY7 51435 8p21.1 human K582-sm 1883988602 QRGAMGPkGEPGIQG sumoylation; protein degradation 29705808 1 1 0 -Cdk1 CDK1 Cell cycle regulation; EC 2.7.11.22; EC 2.7.11.23; KINASE; Kinase, protein; Motility/polarity/chemotaxis; Protein kinase, CMGC; Protein kinase, Ser/Thr (non-receptor) P39951 54237 20p11 rat Y15-p 447610 EKIGEGTyGVVYKGR Pkinase cell cycle regulation 36125973 201 145 3902 -DDX5 DDX5 EC 3.6.4.13; Helicase; Nuclear receptor co-regulator; Nucleolus; RNA splicing; RNA-binding; Spliceosome P17844 1655 17q23.3 human R482-m2 1877752101 VEDRGSGrSRGRGGM molecular association, regulation XRN2(INDUCES) 31267554 1 1 0 represses R-loops -PSEN1 PSEN1 Cell surface; EC 3.4.23.-; Membrane protein, integral; Membrane protein, multi-pass; Mitochondrial; Protease P49768 5663 14q24.2 human S367-p 454173 AVQELSSsILAGEDP Presenilin protein conformation 28132667 2 47 3 PS1 pathogenic conformational shift -RAD9A RAD9A Apoptosis; Cell cycle regulation; DNA replication; Deoxyribonuclease; EC 3.1.11.2 Q99638 5883 11q13.2 human S387-p 449815 SPVLAEDsEGEG___ molecular association, regulation; intracellular localization; phosphorylation cell cycle regulation TOPBP1(INDUCES) 12734188; 20545769; 20724438; 20858457; 25091155; 25454945; 26088138 11 34 1 -GEM GEM G protein; G protein, monomeric; G protein, monomeric, RGK P55040 2669 8q22.1 human S287-p 1211200 NMAFKLKsKSCHDLS molecular association, regulation KPNA5(DISRUPTS) 17605761 2 2 0 interaction abolished in triple phosphomimetic mutant S261/287/289D -CCKBR CCKBR GPCR, family 1; Membrane protein, integral; Membrane protein, multi-pass; Receptor, GPCR P32239 887 11p15.4 human Y438-p 471082 ASLSRLSyTTISTLG molecular association, regulation; phosphorylation SHP-2(INDUCES) 16963136 1 0 0 Mutation of Y438F abrogates AKT phosphorylation on Ser473 and SHP-2 on Y584, but still promotes equivalent amounts of Erk1/2 activation (phospho-Erk epitope). -Snai1 Snail1 C2H2-type zinc finger protein; Transcription factor Q02085 20613 2 H3|2 87.33 cM mouse K137-ub 1872271901 PGLGQLPkQLARLSV protein stabilization; molecular association, regulation carcinogenesis, inhibited; transcription, inhibited GSK3B(INDUCES) 16096638 2 0 0 induces EMT -Esr2 ER-beta DNA-binding; Nuclear receptor O08537 13983 12 C3|12 33.52 cM mouse S61-p 452089 MNYSVPSsTGNLEGG ERbeta_N protein degradation; protein stabilization; protein conformation transcription, altered 11150304; 16984883 2 1 0 phosphorylation results in accelerated degradation, while O-Glycosylation would be predicted to result in stabilization, both localized in nucleus -PIAS1 PIAS1 EC 6.3.2.-; Nuclear receptor co-regulator; SUMO LIGASE; SUMO conjugating system; SUMO ligase; Transcription, coactivator/corepressor O75925 8554 15q23 human S468-p 4700794 DLTIDSSsDEEEEEP molecular association, regulation transcription, inhibited SUMO2(INDUCES); SUMO1(INDUCES); UBC9(INDUCES) 19217413; 24174529 2 9 0 -Limk2 LIMK2 EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, Ser/Thr (non-receptor); Protein kinase, TKL P53670 29524 14q21 rat T505-p 448683 SDRKKRYtVVGNPYW PK_Tyr_Ser-Thr activity, induced 11018042 17 1 1 T505 phosphorylation is also essential for the induction of actin cytoskeletal changes. -CTNND1 CTNND1 Actin-binding; Adaptor/scaffold; Cell adhesion; G protein regulator, misc.; Motility/polarity/chemotaxis O60716 1500 11q12.1 human S312-p 450458 ARRTGTPsDPRRRLR carcinogenesis, induced; cell motility, induced; cell adhesion, inhibited 32589661 4 3 2 -P2rx2 P2X2 Channel, cation; Channel, ligand-gated; Membrane protein, integral; Membrane protein, multi-pass P49653 114115 12q16 rat T372-p 183815300 KKFDKVRtPKHPSSR receptor desensitization, inhibited 28809765 1 0 0 -Trp53 p53 iso2 Activator; DNA-binding; Motility/polarity/chemotaxis; Nuclear receptor co-regulator; Transcription factor; Tumor suppressor Q80ZA1 22059 11 B3|11 42.83 cM mouse K162-ac 59149205 RAMAIYKkSQHMTEV P53 transcription, induced 27705786 2 0 0 -Cdkn1b p27Kip1 Cell cycle regulation; Inhibitor; Oncoprotein; Protein kinase, regulatory subunit P46414 12576 6 G1|6 65.77 cM mouse S178-p 450208 EENVSDGsPNAGTVE cell cycle regulation; cell growth, altered 12856081 5 13 1 -NOP58 NOP5 Cell development/differentiation; Nucleolus; RNA-binding Q9Y2X3 51602 2q33.1 human S502-p 459895 HIKEEPLsEEEPCTS sumoylation 20797634 1 93 22 required for sumoylation of K497 -CTDP1 CTDP1 EC 3.1.3.16; Motility/polarity/chemotaxis; PHOSPHATASE; Protein phosphatase, Ser/Thr (non-receptor); Transcription initiation complex Q9Y5B0 9150 18q23 human S575-p 11276300 AGESLDQsMEEEEEE molecular association, regulation; enzymatic activity, induced transcription, induced GTF2F2(INDUCES) 12591939 1 1 0 -NFKBIA IkB-alpha DNA-binding; Inhibitor P25963 4792 14q13.2 human S262-p 1873119302 QLTWGRPsTRIQQQL phosphorylation carcinogenesis, induced; cell growth, induced; apoptosis, inhibited; transcription, induced 34030642 1 1 0 induce p65 trancsription activity; inhibits phosphorylation of RIP3 and MLKL -Brsk2 BRSK2 EC 2.7.11.1; EC 2.7.11.26; KINASE; Kinase, protein; Protein kinase, CAMK; Protein kinase, Ser/Thr (non-receptor) Q69Z98 75770 7|7 F5 mouse S513-p 3572416 MSNLTPEsSPELAKK protein stabilization; enzymatic activity, inhibited; phosphorylation 23790753 1 7 6 inhibits axon branching (activated in BRSK2 18A mutant) -Alyref2 Refbp2 DNA-binding; RNA-binding Q9JJW6 56009 1|1 H3 mouse R32-m1 13906414 GGGPRRNrPAIARGG molecular association, regulation RNA(DISRUPTS) 20129943 1 1 0 -HSPA1A HSP70 Chaperone; Heat shock protein; Motility/polarity/chemotaxis P0DMV8 3303 6p21.33 human Y525-p 450945 MVQEAEKyKAEDEVQ HSP70 intracellular localization 10843914 1 3 22 Phosphorylation at Y525 facilitates nuclear acumulation of HSP70 following heat stress. -Stxbp1 STXBP1 Vesicle O08599 20910 2 B|2 22.09 cM mouse S241-p 36440508 DRGFDPSsPVLHELT Sec1 protein degradation; ubiquitination 27056679 1 0 0 endocannabinoid-induced depression of glutamate release -Scn4a SCN4A Channel, sodium; Membrane protein, integral; Membrane protein, multi-pass P15390 rat S56-p 50659300 EPERKPRsDLEAGKN activity, induced 26485043 1 0 0 augments SCN4A current -MBD4 MBD4 Apoptosis; DNA repair, damage; Deoxyribonuclease; EC 3.2.2.- O95243 8930 3q21.3 human K377-sm 1877787602 HLHTDILkRGSEMDN DNA repair, induced 31476572 1 1 0 -CALR Calreticulin ACETYLTRANSFERASE; Acetyltransferase; Calcium-binding; Motility/polarity/chemotaxis; Nuclear receptor co-regulator; Secreted; Secreted, signal peptide P27797 811 19p13.13 human K207-ac 4219813 WDFLPPKkIKDPDAS Calreticulin protein conformation; enzymatic activity, induced 18795239; 33585151 2 1 0 K207 of P-domain is the active site residue controlling TAase activity. -ATRX ATRX DNA repair, damage; EC 3.6.4.12; Helicase; Ubiquitin conjugating system P46100 546 Xq21.1 human S2487-p 23052326 RSKNPGPsQGKSM__ cell cycle regulation 25803170 0 3 3 inability of cells to undergo geroconversion following CDK4 inhibition -BRD7 BRD7 Cell cycle regulation; Histone-binding; Transcription regulation; Tumor suppressor Q9NPI1 29117 16q12.1 human K173-ub 1877241401 PGYSMIIkHPMDFST Bromodomain protein degradation cell motility, induced; cell growth, inhibited USP24(INDUCES) 33257797 1 0 0 -MC2R MC2R GPCR, family 1; Membrane protein, integral; Membrane protein, multi-pass; Receptor, GPCR Q01718 4158 18p11.21 human S280-p 456325 PFIYAFRsPELRDAF receptor desensitization, altered; activity, inhibited 12456795 1 0 0 -IKBKG IKKG Adaptor/scaffold; Protein kinase, regulatory subunit Q9Y6K9 8517 Xq28 human S68-p 1226900 LRDAIRQsNQILRER NEMO molecular association, regulation IKKG(DISRUPTS); IKKB(DISRUPTS) 17977820 1 0 0 phosphorylation attenuates amino-terminal protein dimerization; decreases TNF-alpha-induced NF-kB and IKKalpha activity. -UBASH3A STS2 PHOSPHATASE; Protein phosphatase, tyrosine (non-receptor) P57075 53347 21q22.3 human K240-ub 486271 LHLTLAHkFYPHHQR receptor internalization, induced; protein degradation; molecular association, regulation; ubiquitination endocytosis, inhibited EGFR(DISRUPTS) 16429130 2 4 2 Monoubiquitination of Sts1?2 and Hrs affect regulation of cargo sorting -PGR PR DNA-binding; Nuclear receptor; Transcription factor P06401 5241 11q22.1 human S400-p 449842 GAEASARsPRSYLVA Prog_receptor protein degradation; intracellular localization cell growth, induced; transcription, induced 15572662; 25514083 8 3 0 -NR3C2 MCR DNA-binding; Nuclear receptor P08235 4306 4q31.23 human S263-p 18503884 NVGSPLSsPLSSMKS protein degradation; ubiquitination transcription, inhibited 22798426 1 1 0 -PREX1 PREX1 GEF; GEF, Rac/Rho Q8TCU6 57580 20q13.13 human S1169-p 18704703 DTMSYRDsYSECNSN activity, induced cell growth, induced 21042280; 23899556; 27788493 3 0 0 increased Rac activity -MAP3K3 MEKK3 EC 2.7.11.25; KINASE; Kinase, protein; Protein kinase, STE; Protein kinase, Ser/Thr (non-receptor) Q99759 4215 17q23.3 human S526-p 458796 MSGTGMRsVTGTPYW Pkinase enzymatic activity, induced transcription, altered 16362041; 18308725 4 2 0 necessary for MEKK3 T294 phosphorylation and its interaction with 14-3-3beta; S526 functions in LPS-induced IL6 transcription. -Gata4 GATA4 Motility/polarity/chemotaxis; Transcription factor Q08369 14463 14 D1|14 33.24 cM mouse K318-ac 18380903 KEGIQTRkRKPKNLN cell growth, induced; transcription, induced 20833366 1 0 0 -Nos3 eNOS Amino Acid Metabolism - arginine and proline; EC 1.14.13.39; Oxidoreductase P70313 18127 5 A3|5 11.32 cM mouse Y656-p 2811400 FGLGSRAyPHFCAFA Flavodoxin_1 molecular association, regulation HSP90A(DISRUPTS); PKM(DISRUPTS); Calmodulin(DISRUPTS) 31328803 6 1 0 preserves Nitric Oxide bioavailability, inhibits s-nitrosation of PKM2 -ZBTB16 PLZF C2H2-type zinc finger protein; DNA-binding; Oncoprotein; Transcription, coactivator/corepressor Q05516 7704 11q23.2 human K653-ac 50455005 QKHMKGHkPEEIPPD molecular association, regulation; acetylation; intracellular localization chromatin organization, altered; transcription, inhibited DNA(INDUCES) 26405459 1 0 0 induces histone acetylation and DNA hypermethylation -Gria1 GluR1 Channel, calcium; Channel, ligand-gated; Membrane protein, integral; Membrane protein, multi-pass P19490 50592 10q22 rat S849-p 448565 FCLIPQQsINEAIRT activity, induced; protein processing; intracellular localization; receptor internalization, inhibited neural plasticity GluR2(INDUCES) 15630695; 17428797; 17472959; 26626486; 34251729; 35053838; 35625355; 8663994 94 4 3 -SMAD2 SMAD2 DNA-binding; Transcription factor Q15796 4087 18q21.1 human S250-p 448795 TGSPAELsPTTLSPV activity, induced; protein degradation; protein stabilization; molecular association, regulation; intracellular localization; protein conformation; phosphorylation cell growth, induced; cell differentiation, induced; cell motility, altered; cell motility, inhibited; transcription, induced; transcription, inhibited; signaling pathway regulation SETD2(INDUCES); SMAD4(INDUCES) RNA(INDUCES) 10197981; 12193595; 19115199; 27153775; 31995604; 33676893; 34504019 11 1 0 inhibits C-terminal phosphorylation and hence TGF-B signaling -MARCKS MARCKS Actin-binding; Motility/polarity/chemotaxis P29966 4082 6q21 human S163-p 447787 KRFSFKKsFKLSGFS MARCKS exocytosis, inhibited 21762971 24 30 7 induce MUC5AC secretion by cold -Drd1 DRD1 GPCR, family 1; Membrane protein, integral; Membrane protein, multi-pass; Receptor, GPCR P18901 24316 17p14 rat T268-p 3078003 KMSFKREtKVLKTLS 7tm_1 intracellular localization 11901220 1 0 0 -CNN1 calponin 1 Actin-binding; Contractile; Motility/polarity/chemotaxis; Myosin-binding P26932 396522 chicken S175-p 450890 MGTNKFAsQQGMTAY Calponin molecular association, regulation ACTA1(DISRUPTS) 10873572 3 2 0 f-actin (rabbit skeletal muscle) shown by co-sedimentation -CDC25C CDC25C EC 3.1.3.48; Motility/polarity/chemotaxis; PHOSPHATASE; Protein phosphatase, dual-specificity P30307 995 5q31.2 human T130-p 449911 PAQLLCStPNGLDRG cell cycle regulation; cell adhesion, altered 20668692; 8119945 4 0 7 -Nos3 eNOS Amino Acid Metabolism - arginine and proline; EC 1.14.13.39; Oxidoreductase Q62600 24600 4q11 rat S1178-p 467802 RIRTQSFsLQERQLR enzymatic activity, induced 17376767 11 8 1 -NR4A2 NR4A2 DNA-binding; Nuclear receptor P43354 4929 2q24.1 human S125-p 487428 GSVYYKPsSPPTPTT transcription, induced 17890097 1 0 0 S125C mutation attenuated NR4A2 -induced transcriptional activity. -NPHP1 NPHP1 Cell adhesion O15259 4867 2q13 human S121-p 26395106 PTEEEEEsESEDSED molecular association, regulation; intracellular localization PACS-1(INDUCES) 16308564 1 0 0 -Rps6ka1 p90RSK EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, AGC; Protein kinase, Ser/Thr (non-receptor); Translation Q63531 81771 5q36 rat S363-p 447989 TSRTPRDsPGIPPSA Pkinase_C activity, induced 9430688 42 47 4 -RUNX2 AML3 DNA-binding; Transcription factor Q13950 860 6p21.1 human S43-p 10892805 PGKMSDVsPVVAAQQ molecular association, regulation osterix(INDUCES) 25122769 2 1 0 -Ikzf1 Ikaros C2H2-type zinc finger protein; DNA-binding; Transcription factor Q03267 22778 11 A1|11 7.02 cM mouse S388-p 451351 REASPSNsCQDSTDT activity, inhibited cell cycle regulation DNA(DISRUPTS) 15024069 2 1 3 -NFATC4 NFAT3 DNA-binding; Transcription factor Q14934 4776 14q12 human S170-p 448860 GGAFFSPsPGSSSLS intracellular localization; activity, inhibited cell differentiation, altered; transcription, altered; cell growth, altered 11997522; 17213202 7 0 1 -PCYT1A PCYT1A EC 2.7.7.15; Lipid Metabolism - glycerophospholipid; Transferase P49585 5130 3q29 human S319-p 451322 QAISPKQsPSSSPTR intracellular localization 32186954 4 46 10 -CBX4 CBX4 EC 6.3.2.-; SUMO LIGASE; SUMO conjugating system; SUMO ligase; Transcription, coactivator/corepressor O00257 8535 17q25.3 human T497-p 470079 SLQVKPEtPASAAVA sumoylation; molecular association, regulation; intracellular localization; enzymatic activity, induced cell cycle regulation; transcription, inhibited RING1(INDUCES) 17018294; 30317550 2 0 0 -Stxbp3 STXBP3 Vesicle Q60770 20912 3|3 F3 mouse Y219-p 463816 EKKLEDYyKIDEKGL Sec1 molecular association, regulation; intracellular localization exocytosis, induced STX4(DISRUPTS); DOC2B(INDUCES) 16638745; 18541526; 21444687; 23937695 4 0 0 GLUT4 vesicle exocytosis induced; Munc18c dissociation from syntaxin 4; 2-deoxy-glucose uptake in adipocytes -Ntrk1 TrkA EC 2.7.10.1; KINASE; Kinase, protein; Membrane protein, integral; Oncoprotein; Protein kinase, TK; Protein kinase, tyrosine (receptor) P35739 59109 2q34 rat Y683-p 447763 RDIYSTDyYRVGGRT PK_Tyr_Ser-Thr molecular association, regulation; enzymatic activity, induced cell cycle regulation; cytoskeletal reorganization; cell growth, altered DNAJA3(INDUCES) 10656690; 14647472; 15753086 14 3 10 -AKAP12 AKAP12 Adaptor/scaffold Q02952 9590 6q25.1 human S696-p 480148 KKRARRGsSSDEEGG receptor desensitization, inhibited; molecular association, regulation ADRB2(INDUCES) 14657015 1 25 159 -Mip AQP0 Channel, misc.; Membrane protein, integral; Membrane protein, multi-pass; Transporter, aquaporin family P09011 25480 7q11 rat S229-p 453399 FPRLKSVsERLSILK molecular association, regulation 22194645 2 2 0 No differences in the interaction with filensin between the AQP0 COOH-terminal peptide and its pseudophosphorylated proteins -GRIN2A NMDAR2A Channel, ligand-gated; Membrane protein, integral; Membrane protein, multi-pass Q12879 2903 16p13.2 human Y1267-p 461052 PATGEQVyQQDWAQN NMDAR2_C activity, induced 10195142 4 1 25 potentiation of receptor currents mediated by Src -Stk17b DRAK2 EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, CAMK; Protein kinase, Ser/Thr (non-receptor) Q91XS8 170904 9q31 rat S350-p 1735800 PEDDSLLsKRFRFDD intracellular localization 18084041 2 1 0 regulates the activity of the NLS -AKAP13 AKAP13 Adaptor/scaffold; GEF; GEF, Rac/Rho; Nuclear export; Nuclear receptor co-regulator; Oncoprotein Q12802 11214 15q25.3 human S1565-p 452184 LSPFRRHsWGPGKNA molecular association, regulation; activity, inhibited; phosphorylation 14-3-3 beta(INDUCES); 14-3-3 sigma(INDUCES); 14-3-3 gamma(INDUCES) 15229649; 15324660; 36402225 3 27 11 regulates phosphorylation at T2467 -Add1 ADD1 Cytoskeletal; Motility/polarity/chemotaxis Q63028 24170 14q21 rat S724-p 449829 KKKFRTPsFLKKSKK intracellular localization cytoskeletal reorganization 9607561; 9679146 24 57 158 -Osbpl3 OSBPL3 iso3 Endoplasmic reticulum D3Z194 71720 6|6 B2.3 mouse S250-p 3212427 DVLHRTYsAPAINAI apoptosis, inhibited 31509750 1 32 11 inhibits insulin secretion -Rps6ka1 p90RSK EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, AGC; Protein kinase, Ser/Thr (non-receptor); Translation Q63531 81771 5q36 rat S154-p 10355000 GDLFTRLsKEVMFTE Pkinase molecular association, regulation; intracellular localization; enzymatic activity, induced 14-3-3 beta(INDUCES) 12618428 2 0 0 !4-3-3 binding inhibits S363 andd S380 phosphorylation and enzyme activity.; 14-3-3B binding in vitro and in vivo -YAP1 YAP1 Oncoprotein; Transcription, coactivator/corepressor P46937 10413 11q22.1 human S419-p 31884052 TPDDFLNsVDEMDTG protein degradation 28481329 1 4 0 -Mff MFF Membrane protein, integral; Mitochondrial Q6PCP5 75734 1|1 C5 mouse S129-p 470753 GRLKRERsMSENAVR Miff molecular association, regulation signaling pathway regulation DRP1(INDUCES) 31693892 4 43 91 -DDX3X DDX3 Cell cycle regulation; EC 3.6.4.13; Helicase; RNA-binding; Spliceosome; Translation initiation O00571 1654 Xp11.4 human S102-p 11183059 RFDDRGRsDYDGIGS molecular association, regulation; phosphorylation IRF3(INDUCES) 23478265 1 9 68 102A (mutant) increased autophosphorylation of IRF3 -SOCS3 SOCS3 Inhibitor O14543 9021 17q25.3 human Y221-p 450447 IREFLDQyDAPL___ protein degradation; molecular association, regulation transcription, altered NCK1(INDUCES); CRK(INDUCES); TCEB1(DISRUPTS) 12783885; 15173187; 16352613 4 0 0 -Plcb4 PLCB4 Carbohydrate Metabolism - inositol phosphate; EC 3.1.4.11; Phospholipase Q91UZ1 18798 2 F3|2 66.64 cM mouse T886-p 468465 NPAKANVtPQSSSEL activity, induced signaling pathway regulation 33970189 1 25 0 T cell activation; induces TCR signaling -SNAI1 Snail1 C2H2-type zinc finger protein; Transcription factor O95863 6615 20q13.13 human S92-p 452602 VAELTSLsDEDSGKG protein degradation; molecular association, regulation; activity, inhibited carcinogenesis, inhibited; transcription, inhibited; transcription, altered SAP30(INDUCES) 19923321; 22562247 2 5 0 reqired for cell survival ; maintenance of epithelial phenotype, prevents EMT -Rrad RRAD G protein; G protein, monomeric; G protein, monomeric, RGK O88667 56437 8|8 D3 mouse S39-p 4700224 APPLHRRsMPVDERD activity, induced; molecular association, regulation CACNA1C(DISRUPTS) 31969708 2 16 0 induces Cav1.2 currents -SNAI1 Snail1 C2H2-type zinc finger protein; Transcription factor O95863 6615 20q13.13 human K235-ub 231166704 QTHSDVKkYQCQACA protein stabilization 28892081 1 0 0 metastasis -TAOK1 TAO1 EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, STE; Protein kinase, Ser/Thr (non-receptor) Q7L7X3 57551 17q11.2 human T440-p 23150854 RNREHFAtIRTASLV molecular association, regulation cytoskeletal reorganization MYL5(INDUCES); DBN1(INDUCES) Other(INDUCES) 25456499; 36595571 2 2 1 induces binding to membrane phosphoinositides; spine development -GRIK1 GluR5 iso2 Channel, ligand-gated; Membrane protein, integral; Membrane protein, multi-pass P39086-2 2897 21q21.3 human S879-p 457626 QKKIKKKsRTKGKSS receptor desensitization, altered; receptor internalization, altered 17898803 2 0 0 induced by phorbol ester -CDC25A CDC25A EC 3.1.3.48; Motility/polarity/chemotaxis; PHOSPHATASE; Protein phosphatase, dual-specificity P30304 993 3p21.31 human S82-p 450248 GSSESTDsGFCLDSP protein degradation; molecular association, regulation; ubiquitination; phosphorylation cell cycle regulation BTRC(INDUCES); FBW1B(INDUCES) 14603323; 14681206; 14752276; 15798217; 19734889; 20348946 6 0 0 -ELAVL1 HuR RNA-binding Q15717 1994 19p13.2 human S304-p 27156803 EAAMAIAsLNGYRLG RRM_1 protein degradation; molecular association, regulation; intracellular localization BTRC(INDUCES) 23115237 1 0 0 -SNCA SNCA Adaptor/scaffold P37840 6622 4q22.1 human Y125-p 448279 VDPDNEAyEMPSEEG Synuclein molecular association, regulation; protein stabilization; activity, inhibited SNCA(DISRUPTS) 11821392; 24412932; 36690898 9 1 0 -H3c1 H3 DNA-binding P68433 360198 13|13 A3.1 mouse K4-me 1668802 ____ARTkQTARKST Histone transcription, induced 21703230 29 1 0 -HSP90AA1 HSP90A Chaperone; Heat shock protein P07900 3320 14q32.31 human K615-me 1873645100 ANMERIMkAQALRDN HSP90 molecular association, regulation cytoskeletal reorganization Titin(INDUCES) 22241783 1 1 0 -FANCA FANCA DNA repair, damage O15360 2175 16q24.3 human S1449-p 460787 AAPDADLsQEPHLF_ molecular association, regulation; ubiquitination chromatin organization, altered DNA(INDUCES) 19109555 1 5 33 level of monoubiquitinated FANCD2 was decreased in FANCA S1449A mutant -TP53 p53 Activator; DNA-binding; Motility/polarity/chemotaxis; Nuclear receptor co-regulator; Transcription factor; Tumor suppressor P04637 7157 17p13.1 human K382-ac 458977 QSTSRHKkLMFKTEG protein degradation; molecular association, regulation; acetylation; protein stabilization; activity, induced; ubiquitination; intracellular localization; protein conformation cell cycle regulation; apoptosis, altered; carcinogenesis, induced; apoptosis, induced; cell motility, inhibited; signaling pathway regulation; cell growth, induced; transcription, inhibited; carcinogenesis, inhibited; cell growth, inhibited; transcription, induced; transcription, altered; DNA repair, induced; autophagy, induced; cell differentiation, induced; apoptosis, inhibited CBFB(DISRUPTS); polybromo 1(INDUCES); TAF1(INDUCES); S100B(DISRUPTS); S100A2(DISRUPTS); CBP(INDUCES); BCL2L2(INDUCES); MDC1(INDUCES); POLA2(INDUCES); ING4(INDUCES); ING5(INDUCES); BANP(INDUCES); BRMS1L(INDUCES); p53(DISRUPTS); GTF2H1(INDUCES); MYH11(DISRUPTS); PC4(INDUCES); p21Cip1(DISRUPTS); MDM2(INDUCES) DNA(INDUCES); DNA(DISRUPTS) 10910364; 11094089; 11099047; 11250899; 11672523; 11740489; 11971195; 12006491; 12093737; 12421820; 12750254; 14522900; 14665630; 14759370; 14976551; 14982997; 15141169; 15361854; 15520174; 15746940; 16107876; 16291740; 16322229; 16426974; 16537920; 16540636; 16618797; 17047066; 17121856; 17272277; 17403783; 17668048; 17977830; 17996705; 18056437; 18243116; 18419600; 18485870; 18523266; 18769132; 19085961; 19265193; 19339993; 19377469; 19731376; 19819244; 19828042; 20024960; 20075864; 20157519; 20171273; 20935676; 21297583; 21465263; 21565980; 21586571; 21654327; 21857907; 22081073; 22249259; 22285752; 22576474; 22731250; 22815158; 23148227; 23184057; 23297003; 23329847; 23384296; 23416275; 23431171; 23576563; 23678107; 23982736; 24038750; 24077923; 24194938; 25426556; 25521755; 25605253; 26363315; 26387755; 26578795; 26629991; 26784898; 27208501; 27345396; 27402830; 27423454; 28182012; 28410205; 28601088; 28655792; 30710424; 31296660; 31634504; 31680191; 31863007; 32093281; 32224984; 32831651; 33097607; 33982878; 34188177; 34798143; 34947995; 35872650; 36007676; 36257192; 36575468; 9288740; 9744860 216 10 0 -P2RY1 P2RY1 GPCR, family 1; Membrane protein, integral; Membrane protein, multi-pass; Receptor, GPCR P47900 5028 3q25.2 human S252-p 60152501 IYKDLDNsPLRRKSI 7tm_1 protein stabilization; molecular association, regulation PIN1(INDUCES) 27863418 1 0 0 -SKIL SKIL Cell development/differentiation; Transcription, coactivator/corepressor P12757 6498 3q26.2 human K383-sm 3144803 QSWYPVIkQEGDHVS carcinogenesis, inhibited; cell growth, inhibited; transcription, inhibited 16966324; 28493978 3 0 0 -Cgas cGAS EC 2.7.7.86 Q8C6L5 214763 9|9 E1 mouse K491-m1 1883544404 KSKEFLSkKIEYERN molecular association, regulation DNA repair, inhibited CCDC101(INDUCES); PARP1(DISRUPTS) 35210392 1 0 0 -Abca1 ABCA1 Membrane protein, integral; Membrane protein, multi-pass; Transporter; Transporter, ABC family; Vesicle P41233 11303 4 B2|4 28.57 cM mouse T1305-p 450309 IDPESREtDLLSGMD protein degradation; protein processing 12869555 1 0 0 Mutants showed increase of cell surface protein levels. ; T1286A and T1305A mutants are not degraded by calpain or stabilized by apoA-1. -Gja1 GJA1 Channel, misc.; Membrane protein, integral; Membrane protein, multi-pass; Motility/polarity/chemotaxis P08050 24392 20q11 rat S365-p 459207 IVDQRPSsRASSRAS activity, induced; protein conformation 12417300; 18086922; 29021339 15 15 2 channel open, (S373 dephosphorylated) -MDC1 MDC1 Cell cycle regulation Q14676 9656 6p21.33 human T98-p 20583303 DCGSLNGtQILRPPK FHA molecular association, regulation; protein conformation cell cycle regulation; DNA repair, induced; signaling pathway regulation MDC1(INDUCES); BRCA1(INDUCES); 53BP1(INDUCES) 21705321; 22234877 2 1 0 T98A mutation disrupts MDC1 dimerization ; ATM signaling following DNA damage; important for the structural stability of MDC1 -VIM Vimentin Cytoskeletal; Motility/polarity/chemotaxis P08670 7431 10p13 human S66-p 451765 GVYATRSsAVRLRSS Filament_head molecular association, regulation cytoskeletal reorganization Vimentin(DISRUPTS) 11895474 5 11 20 -Musk MUSK EC 2.7.10.1; KINASE; Kinase, protein; Membrane protein, integral; Protein kinase, TK; Protein kinase, tyrosine (receptor) Q61006 18198 4 B3|4 31.87 cM mouse Y553-p 2848304 RLHPNPMyQRMPLLL molecular association, regulation; intracellular localization DOK7(INDUCES); CRK(INDUCES) 34163073 2 3 0 peptide pull-down assay, recruitment of CRK -Tnnt2 TNNT2 iso2 Motility/polarity/chemotaxis; Motor P50753-2 24837 13q13 rat T204-p 451556 RKSGKRQtEREKKKK Troponin protein conformation 24708997 7 0 0 T204E mutant blunts Ca2+ sensitivity, PKC phosphorylation of these residues can increase or decrease Ca2+ sensitivity and cardiac regulation -TP53 p53 Activator; DNA-binding; Motility/polarity/chemotaxis; Nuclear receptor co-regulator; Transcription factor; Tumor suppressor P04637 7157 17p13.1 human K386-ac 486382 RHKKLMFkTEGPDSD protein stabilization; molecular association, regulation; intracellular localization apoptosis, induced; transcription, induced; transcription, altered S100B(DISRUPTS); S100A2(DISRUPTS) 18485870; 19339993; 19377469; 19819244; 21297583; 31680191 12 2 1 20, 164, 305, 320, 370/372/373, 381/382/386 K-R mutants diminsished transactivation, and selective regulation of target genes expression through distinct mechanisms; ZNF420 (Apak) represses p53 activity by attenuating its acetylation -APP APP Apoptosis; Cell surface; Membrane protein, integral; Receptor, misc.; Transcription factor P05067 351 21q21.3 human S679-p 480465 DAEFRHDsGYEVHHQ Beta-APP molecular association, regulation; protein stabilization; protein conformation cytoskeletal reorganization APP(INDUCES); APP(DISRUPTS) 21527912; 22267728; 25023775; 27252381; 28031462; 30210271; 31097588 9 2 0 modify the morphologies of amyloid fibrils -RB1 Rb Nuclear receptor co-regulator; Oncoprotein; Transcription, coactivator/corepressor; Tumor suppressor P06400 5925 13q14.2 human T252-p 449821 PINGSPRtPRRGQNR activity, induced; protein degradation; acetylation; molecular association, regulation; ubiquitination; activity, inhibited; phosphorylation cell cycle regulation; carcinogenesis, induced; cell growth, inhibited; transcription, induced; transcription, altered; signaling pathway regulation; cell growth, induced; apoptosis, inhibited; transcription, inhibited BRD4(DISRUPTS); E2F1(INDUCES); EID1(DISRUPTS); HDAC5(DISRUPTS) 17599043; 17996702; 22279936; 27642049; 33419772; 36274096; 36637424 21 23 68 -Mtor mTOR Autophagy; EC 2.7.11.1; KINASE; Kinase, protein; Motility/polarity/chemotaxis; Protein kinase, Ser/Thr (non-receptor); Protein kinase, atypical Q9JLN9 56717 4 E2|4 78.76 cM mouse S2448-p 447578 RSRTRTDsYSAGQSV intracellular localization cell cycle regulation; carcinogenesis, induced; cell motility, induced; transcription, induced; signaling pathway regulation; neural plasticity; autophagy, induced; cell growth, induced; cell differentiation, induced; apoptosis, inhibited; autophagy, inhibited; translation, induced 14559816; 18851840; 21550972; 32071086; 33637094; 34695513; 35210408; 35696363; 35857844; 36012713; 36310322 218 18 106 -STK39 STLK3 EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, STE; Protein kinase, Ser/Thr (non-receptor) Q9UEW8 27347 2q24.3 human S323-p 450932 LCLQKDPsKRPTAAE Pkinase enzymatic activity, induced 14988727 1 0 0 -Ulk1 ULK1 Autophagy; EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, Other; Protein kinase, Ser/Thr (non-receptor) O70405 22241 5|5 F mouse K162-ac 27850502 NPSNIRVkIADFGFA Pkinase enzymatic activity, induced autophagy, induced 22717509 2 1 0 -AGAP2 CENTG1 iso2 GAP; GAP, ARF; Motility/polarity/chemotaxis; Tumor suppressor Q99490-2 116986 12q14.1 human S472-p 477808 RNLARALsTDCTPSG protein degradation; molecular association, regulation; phosphorylation apoptosis, inhibited; transcription, inhibited; signaling pathway regulation UNC5B(INDUCES) 21460185 1 12 102 regulates p53 stability and transcription, induces Akt and Akt-p53 pathway -Ndufs4 NDUFS4 EC 1.6.5.3; EC 1.6.99.3; Energy Metabolism - oxidative phosphorylation; Mitochondrial; Oxidoreductase Q9CXZ1 17993 13|13 D2.2 mouse S173-p 2103602 WNKRTRVsTK_____ protein stabilization signaling pathway regulation 32641832 3 1 0 Regulates HIF1 pathway -LYN LYN EC 2.7.10.2; KINASE; Kinase, protein; Oncoprotein; Protein kinase, TK; Protein kinase, tyrosine (non-receptor) P07948 4067 8q12.1 human S13-p 1983291 SKGKDSLsDDGVDLK intracellular localization 33004926 1 43 1 -UBTF UBF DNA-binding; Nucleolus; Transcription factor P17480 7343 17q21.31 human K352-ac 25344501 KKCDQKKkDYEVELL HMG_box_2 molecular association, regulation transcription, induced DNA(INDUCES) 21546905 1 1 0 -PRKAA2 AMPKA2 Autophagy; EC 2.7.11.1; EC 2.7.11.27; EC 2.7.11.31; KINASE; Kinase, protein; Protein kinase, CAMK; Protein kinase, Ser/Thr (non-receptor) P54646 5563 1p32.2 human K391-ub 964497646 LDALNTTkPKSLAVK enzymatic activity, inhibited 31996460 1 1 0 -Sox9 SOX9 DNA-binding; Transcription factor Q04887 20682 11 E2|11 77.27 cM mouse R179-me 10338207 YKYQPRRrKSVKNGQ molecular association, regulation cell cycle regulation; cell growth, induced; transcription, induced CTNNB1(DISRUPTS) 19725955 1 0 0 promotes cyclin D1 expression, regulates endochondral ossification, chondrocyte/cartilage development during embryogenesis -RPS6KA1 p90RSK EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, AGC; Protein kinase, Ser/Thr (non-receptor); Translation Q15418 6195 1p36.11 human K110-sm 1881518209 VRDRVRTkMERDILA molecular association, regulation; phosphorylation EIF4B(INDUCES) 34871326 1 0 0 SUMO-SIM interaction contributes to RSK1-eIF4B association; sites incudinge IF4B (Ser 422 and Ser 425, 29.91 fold), SETD1A (Ser 915 and Ser 916, 25.76 fold), LMNA (Ser 404 and Ser 406, 16.42 fold), ZNF 217 (Ser 975, 13.27 fold); SUMOylation is required for is required for replication and virus production of KSHV; affect eIF4B phosphorylation by RSK1 in vitro; SUMOylation affects the phosphorylation levels of its substrates -Sh3pxd2a Tks5 Adaptor/scaffold O89032 14218 19|19 C3 mouse Y619-p 3736027 ALEEETIyENEGFRP cell cycle regulation; cell motility, altered 18515860 1 1 1 -HAVCR2 TIM-3 Membrane protein, integral; Receptor, misc. Q8TDQ0 84868 5q33.3 human Y265-p 470136 IRSEENIyTIEENVY receptor inactivation, induced; molecular association, regulation; intracellular localization signaling pathway regulation; transcription, inhibited STAT1(INDUCES); Fyn(INDUCES); P38A(INDUCES); PIK3R1(INDUCES) 26492563; 27757304; 31848194 5 0 0 suppresses TCR-mediated activation of the NF-kB/NFAT reporter activity; PI3K-Akt-mTOR pathway for NK cells in liver; Galectin-9 increased the binding between Tim-3- and STAT1, nuclear localization of STAT1 is linhibited, enhanced SOCS1 expression -DDX5 DDX5 EC 3.6.4.13; Helicase; Nuclear receptor co-regulator; Nucleolus; RNA splicing; RNA-binding; Spliceosome P17844 1655 17q23.3 human R502-m1 6008922 DRYSAGKrGGFNTFR P68HR molecular association, regulation XRN2(INDUCES) 31267554 1 7 53 represses R-loops -CTNNB1 CTNNB1 Actin-binding; Cell adhesion; Motility/polarity/chemotaxis; Nuclear receptor co-regulator; Oncoprotein; Transcription factor P35222 1499 3p22.1 human T102-p 3075002 RAAMFPEtLDEGMQI protein degradation cell motility, altered CTNNA1(INDUCES) 12432063 2 0 0 -IRS2 IRS2 Adaptor/scaffold; Motility/polarity/chemotaxis Q9Y4H2 8660 13q34 human S1100-p 453065 PEAARVAsPTSGVKR cell growth, inhibited 25297629 2 43 0 induces immunogenicity, phospho-peptidesfor T-cell recognition showed some control of tumor growth in vivo -Dab1 DAB1 iso2 Adaptor/scaffold P97318-2 13131 4 C6|4 47.79 cM mouse T385-p 479416 AMFQGPLtPLATVPG phosphorylation 16529723 1 0 0 inhibits tyrosine phosphorylation -Tbx21 TBX21 DNA-binding; Transcription factor Q9JKD8 57765 11|11 D mouse S502-p 322212300 RRISPYPsSGDSSSP cell growth, inhibited; transcription, induced 29133416 1 0 0 IFN? transcription, attenuates colon cancer metastasis in RSK2 KO mice -Dvl1 DVL1 Inhibitor P51141 13542 4 E2|4 87.61 cM mouse S142-p 470074 TGTESMVsHRRERAR Dishevelled activity, induced cell differentiation, altered 16965538 1 0 0 contributes to B-catenin-dependent Wnt signaling; mutation of this site inhibits double axis formation in Xenopus embryos -IRF7 IRF7 DNA-binding; Transcription factor Q92985 3665 11p15.5 human S479-p 2868600 SLDSSSLsLCLSSAN activity, induced; molecular association, regulation; intracellular localization; protein conformation transcription, induced H4(DISRUPTS) 10893229; 25225665 4 0 0 -PRKG1 PKG1 EC 2.7.11.12; KINASE; Kinase, protein; Protein kinase, AGC; Protein kinase, Ser/Thr (non-receptor) Q13976 5592 10q11.23-q21.1 human S65-p 51573802 TTRAQGIsAEPQTYR ubiquitination; enzymatic activity, induced 12080049; 19168131 3 0 0 -SIRT6 SIRT6 DEACETYLASE; DEUBIQUITINASE; Deacetylase; EC 2.4.2.31; EC 3.5.1.-; Transferase Q8N6T7 51548 19p13.3 human K33-ac 1876885600 PPEELERkVWELARL chromatin organization, altered; cell growth, inhibited; DNA repair, inhibited 32538779 1 0 0 -Cdk2 CDK2 Cell cycle regulation; EC 2.7.11.22; KINASE; Kinase, protein; Protein kinase, CMGC; Protein kinase, Ser/Thr (non-receptor) P97377 12566 10|10 D3 mouse T160-p 447739 GVPVRTYtHEVVTLW Pkinase enzymatic activity, induced 11509654 40 35 237 -NR1H4 NR1H4 iso2 DNA-binding; Nuclear receptor Q96RI1-2 9971 12q23.1 human S154-p 4245800 CKGFFRRsITKNAVY zf-C4 activity, induced; protein degradation; molecular association, regulation transcription, induced; transcription, inhibited PGC-1 alpha(INDUCES) 18755856; 27571290 2 0 0 -HSPB1 HSP27 Chaperone; Heat shock protein; Motility/polarity/chemotaxis; SUMO LIGASE; SUMO ligase P04792 3315 7q11.23 human S15-p 448401 FSLLRGPsWDPFRDW protein degradation; sumoylation; protein stabilization; molecular association, regulation; intracellular localization; protein conformation; phosphorylation carcinogenesis, induced; apoptosis, altered; signaling pathway regulation; transcription, altered; autophagy, induced; apoptosis, inhibited; cytoskeletal reorganization; transcription, inhibited; cell growth, altered p53(INDUCES); HSF1(DISRUPTS); hnRNP D0(DISRUPTS); HSP27(DISRUPTS) 11383510; 12367505; 15581903; 18477563; 19597476; 21245386; 21989268; 23950959; 32570757; 34477462; 34516752; 34851698; 36701233 52 78 30 induces lysophagy -MAPRE1 EB1 Cytoskeletal; Motility/polarity/chemotaxis Q15691 22919 20q11.21 human S40-p 59049801 TKIEQLCsGAAYCQF CH molecular association, regulation; protein conformation cytoskeletal reorganization Restin(INDUCES); dynactin 1(INDUCES); TUBB(INDUCES) 27721984; 28039481 2 1 0 astral microtubule stability ; regulating astral microtubule stability and spindle orientation/positioning -PFKFB3 PFKFB3 Carbohydrate Metabolism - fructose and mannose; EC 2.7.1.105; EC 3.1.3.46; KINASE; Kinase, other; Motility/polarity/chemotaxis; PHOSPHATASE; Phosphatase (non-protein) Q16875 5209 10p15.1 human S269-p 58109402 QGRIGGDsGLSSRGK His_Phos_1 protein degradation; enzymatic activity, inhibited 27585591 1 1 0 -IGF2BP1 IGF2BP1 RNA-binding; Translation O42254 395953 chicken Y396-p 458348 SVSGAAPySSFMPPE molecular association, regulation; activity, inhibited cell motility, inhibited RNA(DISRUPTS) 16306994; 26317350 6 0 0 IMP-1 Y396 phosphorylation interferes with its binding to beta-actin mRNA, thereby promoting beta-actin translation.; Y396F enhanced CNC emigration -ACLY ACLY Carbohydrate Metabolism - citrate (TCA) cycle; EC 2.3.3.8; Lyase; Transferase P53396 47 17q21.2 human K17-ac 40662704 TGKELLYkFICTTSA protein degradation; molecular association, regulation cell growth, altered ARHGEF3(INDUCES) 36241648 1 1 4 -STAT1 STAT1 DNA-binding; Transcription factor P42224 6772 2q32.2 human K413-ac 459199 HLQLKEQkNAGTRTN STAT_bind molecular association, regulation; intracellular localization; phosphorylation cell growth, inhibited; apoptosis, induced; transcription, induced; signaling pathway regulation; transcription, inhibited PPAR-gamma(INDUCES); NFkB-p65(INDUCES) DNA(INDUCES); DNA(DISRUPTS) 16481475; 19171783; 21576370; 26504087 4 0 1 induces dephosphorylation STAT1, regulates STAT1-associated cytokine signaling; CD36 expression; association with NFkB inhibits NFkB-DNA binding ; inhibition of transcription and nuclear import is a result of its disruption of DNA binding, and nuclear import signal. and not acetylation -SUMO1 SUMO1 Nuclear receptor co-regulator; Ubiquitin-like modifier P63165 7341 2q33.1 human K39-sm 2358309 SEIHFKVkMTTHLKK Rad60-SLD molecular association, regulation DAXX(INDUCES) 21474068 2 1 0 -NUP98 NUP98 iso2 Motility/polarity/chemotaxis; Nucleoporin P52948-2 4928 11p15.4 human T536-p 3801389 TPTHYKLtPRPATRV intracellular localization 21335236 1 11 15 as multiple sites (13PM) mutant -Nos1 nNOS Amino Acid Metabolism - arginine and proline; EC 1.14.13.39; Oxidoreductase P29476 24598 12q16 rat S1412-p 449830 TNRLRSEsIAFIEES activity, induced; enzymatic activity, induced 11038355; 33470757 14 0 0 decreased production of peroxynitrite, MMP-9 and NLRP3; S1412D mutant displayed faster electron transfer out of the reductase domain and intrincis NO synthesis, but slower steady-state NO synthesis. -GRK1 GRK1 EC 2.7.11.14; KINASE; Kinase, protein; Protein kinase, AGC; Protein kinase, Ser/Thr (non-receptor) P28327 281457 cow T8-p 2528800 MDFGSLEtVVANSAF enzymatic activity, induced 18339619 1 0 0 in vitro -Drgx DRGX DNA-binding Q8BYH0 107751 14|14 B mouse S251-p 34371736 EGSQDKTsPTKEQSE transcription, altered 28049756 1 1 1 -PTPN7 HePTP EC 3.1.3.48; Motility/polarity/chemotaxis; PHOSPHATASE; Protein phosphatase, tyrosine (non-receptor) P35236 5778 1q32.1 human S44-p 448309 RLQERRGsNVALMLD molecular association, regulation ERK2(DISRUPTS) 10559944 3 14 31 -MAVS MAVS Adaptor/scaffold; Membrane protein, integral Q7Z434 57506 20p13 human S347-gl 1872691007 ALTNPAPsKLPINST phosphorylation 31461653 1 1 0 positively regulates phosphorylation of S442 (data from MAVS 7A mutant) -CDKN2D CDKN2D Cell cycle regulation; Inhibitor; Tumor suppressor P55273 1032 19p13.2 human S66-p 6046000 ELLKQGAsPNVQDTS Ank_2 protein degradation; molecular association, regulation; ubiquitination; protein conformation cell cycle regulation CDK6(DISRUPTS) 19063602; 29531090; 32874495 2 2 0 -MAPKAP1 Sin1 Adaptor/scaffold Q9BPZ7 79109 9q33.3 human S367-p 56676494 DGVFEEDsQIDIATV molecular association, regulation; phosphorylation apoptosis, inhibited ECT2(INDUCES) 34982576 1 2 0 induces AKT phosphorylation -BRD4 BRD4 KINASE; Kinase, protein; Protein kinase, Ser/Thr (non-receptor); Protein kinase, atypical O60885 23476 19p13.12 human R181-m1 57691844 VQAKGRGrGRKETGT carcinogenesis, induced; DNA repair, induced; cell growth, induced; transcription, induced 36475791 1 2 0 -Cdk7 CDK7 Cell cycle regulation; EC 2.7.11.22; EC 2.7.11.23; KINASE; Kinase, protein; Nuclear receptor co-regulator; Protein kinase, CMGC; Protein kinase, Ser/Thr (non-receptor) Q03147 12572 13 D1|13 53.23 cM mouse T170-p 448306 GSPNRAYtHQVVTRW Pkinase molecular association, regulation; enzymatic activity, induced CCNH(INDUCES) 7553872 5 71 91 -Lime1 LIME1 Adaptor/scaffold; Membrane protein, integral Q9EQR5 72699 2|2 H4 mouse Y261-p 463811 QGPLENVyESIKEMG LIME1 activity, induced; molecular association, regulation LYN(INDUCES); Lck(INDUCES) 14610044; 16249387 3 3 13 -EIF3F eIF3-epsilon EC 3.4.19.12; Translation; Translation initiation O00303 8665 11p15.4 human T119-p 7098400 GAARVIGtLLGTVDK JAB molecular association, regulation translation, altered; apoptosis, induced eIF3-eta(INDUCES) 19245811 1 1 0 -Pxn PXN Adaptor/scaffold; Cell adhesion; Cytoskeletal; Motility/polarity/chemotaxis Q66H76 360820 12q16 rat S126-p 450227 SFPNKQKsAEPSPTV Paxillin intracellular localization 16537926 8 28 4 necessary for formation of NGF-induced neurite extensions -Cryaa CRYA1 Chaperone; Heat shock protein P24623 24273 20p12 rat S59-p 7106328 LFRTVLDsGISELMT apoptosis, inhibited 21615407 1 3 0 induces cytoprotection against C2-ceramide and staurosporine induced cell death -ARAP3 ARAP3 GAP; GAP, ARF; Motility/polarity/chemotaxis Q8WWN8 64411 5q31.3 human Y1403-p 454957 EELEEPVyEEPVYEE molecular association, regulation carcinogenesis, altered; cell motility, altered; cell adhesion, altered SLP76(INDUCES); VAV2(INDUCES) 21076469; 22750419 3 0 0 suppresses peritoneal dissemination of scirrhous gastric carcinoma cells -SMAD1 SMAD1 DNA-binding; Transcription factor Q15797 4086 4q31.21 human K118-ub 1051005 FPFGSKQkEVCINPY MH1 protein degradation 17963781 1 2 0 -GAB1 GAB1 Adaptor/scaffold; Motility/polarity/chemotaxis Q13480 2549 4q31.21 human Y317-p 449581 PPTPGNTyQIPRTFP molecular association, regulation RASA1(INDUCES); CDK6(INDUCES) 15574420; 19881549 2 7 180 promotes HGF-induced DNA synthesis -Khdrbs1 KHDRBS1 RNA-binding Q60749 20218 4|4 D2.2 mouse T71-p 449877 PPLLPPStPGPDATV activity, induced translation, altered 12478298 1 0 0 regulates splicing -BARD1 BARD1 EC 6.3.2.-; EC 6.3.2.19; Ligase; UBIQUITIN LIGASE; Ubiquitin conjugating system; Ubiquitin ligase Q99728 580 2q35 human S148-p 455770 NSIKMWFsPRSKKVR cell cycle regulation 15855157 3 9 0 resistance to genotoxic stress (mitomycin C) -C3AR1 C3aR GPCR, family 1; Membrane protein, integral; Membrane protein, multi-pass; Receptor, GPCR Q16581 719 12p13.31 human S470-p 27145807 TRSTHCPsNNVISER receptor desensitization, induced; molecular association, regulation transcription, inhibited ARRB2(INDUCES) 23077507 1 3 0 -Slc1a2 GLT1 Membrane protein, integral; Membrane protein, multi-pass; Transporter; Transporter, SLC family P31596 29482 3q32 rat K526-ub 3884553 QSVYDDTkNHRESNS receptor internalization, induced; protein degradation 18805448 1 1 3 -CDK5 CDK5 Cell cycle regulation; EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, CMGC; Protein kinase, Ser/Thr (non-receptor) Q00535 1020 7q36.1 human S47-p 1255792403 DDEGVPSsALREICL Pkinase molecular association, regulation; enzymatic activity, inhibited cell growth, induced; cell motility, inhibited CDK5R1(DISRUPTS) 30217452 1 1 0 -NCF1 p47phox EC 1.-.-.-; Oxidoreductase P14598 653361 7q11.23 human S370-p 451730 PAVPPRPsADLILNR p47_phox_C activity, induced; molecular association, regulation; intracellular localization; enzymatic activity, induced; phosphorylation signaling pathway regulation CYBA(INDUCES) 12056906; 22460559; 9857051 11 0 0 regulates ERK1/2 phosphorylation in cells treated with TNF-alpha -MYC Myc DNA-binding; Nucleolus; Oncoprotein; Transcription factor P01106 4609 8q24.21 human S308-p 10852562 GHSKPPHsPLVLKRC Myc_N protein stabilization 25006129 1 15 6 -Cdkn1a p21Cip1 Cell cycle regulation; Inhibitor P39689 12575 17 A3.3|17 15.12 cM mouse S141-p 447836 GRKRRQTsLTDFYHS protein stabilization; intracellular localization; activity, inhibited 21791608; 24848107 10 1 0 localized to cytoplasm -IKBKB IKKB EC 2.7.11.10; KINASE; Kinase, protein; Protein kinase, Other; Protein kinase, Ser/Thr (non-receptor) O14920 3551 8p11.21 human K147-ub 37036401 RIIHRDLkPENIVLQ Pkinase activity, induced; phosphorylation signaling pathway regulation 25486864 2 2 0 increases STAT3 phosphorylation, activation and signaling -DGKD DGKD EC 2.7.1.107; Kinase, lipid; Lipid Metabolism - glycerolipid; Lipid Metabolism - glycerophospholipid; Motility/polarity/chemotaxis Q16760 8527 2q37.1 human S66-p 452137 MLTKQNNsFQRSKRR PH intracellular localization 15228384 1 0 0 Phosphorylation appears to disrupt translocation of DAGK to the plasma membrane. -NPHS1 NPHS1 Cell adhesion; Immunoglobulin superfamily; Membrane protein, integral O60500 4868 19q13.12 human T1125-p 18507017 QWTGERDtQSSTVST molecular association, regulation ARRB2(INDUCES) 21321125 2 0 0 PICK1 and PKCa are also in this complex -TP63 p63 iso2 DNA-binding; Transcription factor Q9H3D4-2 8626 3q28 human S66-p 451600 SSTFDALsPSPAIPS protein degradation cell growth, inhibited 23166821; 30301786 6 2 0 Anti-clonogenic effects of TGFB require S66,68 phosphorylation. -Cdc25b CDC25B EC 3.1.3.48; Motility/polarity/chemotaxis; Nuclear receptor co-regulator; PHOSPHATASE; Protein phosphatase, dual-specificity P30306 12531 2 F1|2 63.29 cM mouse S149-p 7998663 FTIKRFRsLPVRLLE M-inducer_phosp intracellular localization cell cycle regulation 21212267; 22348958 3 13 26 -MDM2 MDM2 EC 6.3.2.-; EC 6.3.2.19; Inhibitor; Ligase; NEDDYLATION LIGASE; Neddylation Ligase; Nucleolus; Oncoprotein; UBIQUITIN LIGASE; Ubiquitin conjugating system; Ubiquitin ligase Q00987 4193 12q15 human Y302-p 38546303 PEISLADyWKCTSCN zf-RanBP protein stabilization transcription, inhibited UBE2M(INDUCES) 25624478 2 0 0 stabilization of p53 levels, neddylated-P53, represses p53-mediated maspin gene expression -TRIM33 TIF1G EC 6.3.2.-; EC 6.3.2.19; KINASE; Kinase, protein; Ligase; Protein kinase, atypical; Transcription, coactivator/corepressor; UBIQUITIN LIGASE; Ubiquitin conjugating system; Ubiquitin ligase Q9UPN9 51592 1p13.2 human Y1048-p 15406627 MMKVVQVyADTQEIN Bromodomain molecular association, regulation; intracellular localization transcription, induced; signaling pathway regulation SMAD3(DISRUPTS) 30177833 1 1 1 regulates TGFB-SMAD2/3 signaling and epithelial to mesenchymal transition -DAXX DAXX Apoptosis; Nuclear receptor co-regulator; Nucleolus; Transcription, coactivator/corepressor Q9UER7 1616 6p21.32 human S178-p 1189200 AENTASQsPRTRGSR protein degradation; molecular association, regulation apoptosis, inhibited PIN1(INDUCES) 17938171 1 11 2 -FZR1 FZR1 UBIQUITIN LIGASE; Ubiquitin conjugating system Q9UM11 51343 19p13.3 human K135-ac 1881330700 FTYSLSTkRSSPDDG protein stabilization 34244565 1 1 0 SIRT6 deacetylates and promotes degradation of FZR1 by ubiquitylation. -NCOA2 SRC-2 Motility/polarity/chemotaxis; Nuclear receptor co-regulator; Transcription, coactivator/corepressor Q15596 10499 8q13.3 human K731-sm 2793922 PGSEVTIkQEPVSPK DUF4927 molecular association, regulation; intracellular localization transcription, induced AR(INDUCES) 12060666 1 2 0 AR-dependent transcription -THRA TR-alpha DNA-binding; Nuclear receptor; Transcription factor NP_990644 396251 chicken K281-sm 27490404 LSGEMAVkREQLKNG Hormone_recep molecular association, regulation transcription, altered Src(INDUCES); N-CoR1(INDUCES) DNA(DISRUPTS) 27843805 4 0 0 -RB1 Rb Nuclear receptor co-regulator; Oncoprotein; Transcription, coactivator/corepressor; Tumor suppressor P06400 5925 13q14.2 human R787-m2 36533405 SPIPHIPrSPYKFPS Rb_C phosphorylation cell cycle regulation; transcription, inhibited 25348716 1 0 0 -PPARG PPAR-gamma DNA-binding; Nuclear receptor; Transcription factor P37231 5468 3p25.2 human Y78-p 36692605 SSISTPHyEDIPFTR PPARgamma_N protein stabilization; ubiquitination cell differentiation, induced; transcription, induced PGC-1 alpha(INDUCES) 25368164 2 1 0 inhibits ubiquitination -CACNA1C CACNA1C iso4 Channel, calcium; Membrane protein, integral; Membrane protein, multi-pass P15381-4 rabbit S1512-p 460572 DYLTRDWsILGPHHL Ion_trans activity, induced 16820363 5 1 0 -Gckr GCKR Inhibitor; Mitochondrial Q91X44 231103 5 B1|5 17.27 cM mouse S481-p 1873175600 QKFQRELsTKWVLNT molecular association, regulation HK1(INDUCES) 34001623 1 0 0 iinteraction with HK1 inhibits HK1 activity and glycolysis -BIRC5 Survivin Apoptosis O15392 332 17q25.3 human T48-p 18451300 AGFIHCPtENEPDLA BIR molecular association, regulation; intracellular localization cell cycle regulation; apoptosis, altered Borealin(DISRUPTS) 21252625 1 0 0 -Etv1 ETV1 DNA-binding; Oncoprotein; Transcription factor P41164 14009 12 A3|12 17.99 cM mouse S94-p 3059606 KIKKEPHsPCSELGS ETS_PEA3_N activity, induced transcription, induced; signaling pathway regulation 22586091 2 0 0 -MRE11 MRE11A Cell cycle regulation; DNA repair, damage; DNA-binding; Deoxyribonuclease P49959 4361 11q21 human R576-m2 62978402 GRGRGRGrRGGRGQN DNA repair, altered 15741314 0 1 0 -Thrb TR-beta1 DNA-binding; Nuclear receptor P37242 21834 14|14 A2 mouse K146-sm 27490403 LHPSYSCkYEGKCII zf-C4 molecular association, regulation; intracellular localization transcription, altered 34237030 3 0 0 recruitment of transcription factors; thyroid hormone content; normal TSH feedback regulation and TH synthesis -Eef1a1 EEF1A1 Nucleolus; Translation; Translation elongation P62630 171361 8q31 rat K165-m1 8113920 TEPPYSQkRYEEIVK GTP_EFTU molecular association, regulation translation, altered EEF1D(DISRUPTS); eEF1B(DISRUPTS); EEF1G(DISRUPTS) 28108655 2 8 46 -Brsk2 BRSK2 EC 2.7.11.1; EC 2.7.11.26; KINASE; Kinase, protein; Protein kinase, CAMK; Protein kinase, Ser/Thr (non-receptor) Q69Z98 75770 7|7 F5 mouse S468-p 4734921 PNPTPPSsPSVGGVP protein stabilization; enzymatic activity, inhibited; phosphorylation 23790753 1 1 1 inhibits axon branching (activated in BRSK2 18A mutant) -CAV1 caveolin-1 Adaptor/scaffold; Motility/polarity/chemotaxis; Nuclear receptor co-regulator P33724 403980 dog Y14-p 448422 VDSEGHLyTVPIREQ molecular association, regulation cell motility, induced; cell adhesion, induced 27259249 55 45 830 persistency and directionality, cell spreading, metastasis, specific ECM-integrin (beta1) interactions and Y14 phosphorylation are necessary -FOXA2 FOXA2 DNA-binding; Transcription factor Q9Y261 3170 20p11.21 human S111-p 22825101 PHLSPSLsPLGGQAA Forkhead_N carcinogenesis, induced; cell growth, induced; transcription, inhibited; signaling pathway regulation 22196886 1 1 0 -IRF3 IRF3 DNA-binding; Transcription factor Q14653 3661 19q13.33 human S97-p 51637401 LRLAEDRsKDPHDPH IRF molecular association, regulation; intracellular localization transcription, inhibited KPNA2(DISRUPTS) 32130408; 34804040; 35948267 4 2 0 -Grm1 mGluR1 GPCR, family 3; Membrane protein, integral; Membrane protein, multi-pass; Receptor, GPCR P23385 24414 1p13 rat T871-p 4713375 KLPCRSNtFLNIFRR receptor desensitization, induced; molecular association, regulation CAMK2A(INDUCES) 23426668 1 2 3 -TH TH iso3 Amino Acid Metabolism - tyrosine; EC 1.14.16.2; Endoplasmic reticulum; Mitochondrial; Oxidoreductase; Vesicle P07101-3 7054 11p15.5 human S31-p 448544 KQAEAIMsPRFIGRR TOH_N molecular association, regulation; intracellular localization; enzymatic activity, induced; phosphorylation SLC18A2(INDUCES); SNCA(INDUCES) 19833152; 28637871; 7901013; 9920892 43 8 0 absence of S31 and S40 in an alternative spliced variant lacking exon 3 that has reduced enzymatic activity in vitro -PELP1 PELP1 Nuclear receptor co-regulator; Transcription, coactivator/corepressor Q8IZL8 27043 17p13.2 human S1033-p 472322 LAPEALPsQGEVERE DNA repair, induced; apoptosis, inhibited; transcription, induced; transcription, inhibited 24786831; 25788226 2 14 29 modulate levels of E2F1 -HTATSF1 TAT-SF1 Spliceosome; Transcription, coactivator/corepressor O43719 27336 Xq26.3 human S748-p 18016601 GSSFILSsDDDDDDI molecular association, regulation carcinogenesis, induced; DNA repair, induced TOPBP1(INDUCES) 35597237 1 3 0 -H2BC3 H2B DNA-binding P33778 3018 6p22.2 human S36-p 449903 RKRSRKEsYSIYVYK Histone methylation cell differentiation, induced; transcription, inhibited 27151441 7 13 47 enriched presence of EZH2 and H3K27me3 at Wnt gene promoters, suppresses the expression of Wnt genes -CDC6 CDC6 Cell cycle regulation Q99741 990 17q21.2 human S74-p 450915 TPHLPPCsPPKQGKK protein stabilization; molecular association, regulation; intracellular localization cell cycle regulation CDH1(DISRUPTS) 10339564; 16153703; 22179839; 23129444; 24216307; 27246979; 9889196 7 11 1 -TEX14 TEX14 Cancer Testis Antigen (CTA); KINASE; Kinase, protein; Protein kinase, Other; Protein kinase, Ser/Thr (non-receptor) Q8IWB6 56155 17q22 human T728-p 25158901 NLNNMSTtEEYLISK molecular association, regulation; intracellular localization PLK1(INDUCES) 22405274 1 0 0 -Camk2b CAMK2B EC 2.7.11.17; KINASE; Kinase, protein; Protein kinase, CAMK; Protein kinase, Ser/Thr (non-receptor) P08413 24245 14q21 rat T320-p 48915800 NFSVGRQtTAPATMS molecular association, regulation 26291163 1 1 0 inhibits interaction with F-actin, regulates synaptic plasticity -PER2 PER2 Nuclear receptor co-regulator; Nucleolus; Transcription factor O15055 8864 2q37.3 human S696-p 468399 EMVEDAAsGPESLDC carcinogenesis, induced; cell growth, induced 30746467 2 6 0 -USO1 TAP Motility/polarity/chemotaxis; Vesicle O60763 8615 4q21.1 human S942-p 450465 EEEDELEsGDQEDED Uso1_p115_C intracellular localization 9478999 3 69 42 regulates association with Golgi membrane -SGO1 SGO1 Cell cycle regulation Q5FBB7 151648 3p24.3 human S507-p 486242 TDLCFLNsPIFKQKK chromatin organization, altered 17621308 1 12 5 required for proper association between the kinetochore and spindle microtubules -Ace2 ACE2 EC 3.4.17.23; Membrane protein, integral; Protease Q8R0I0 70008 X F5|X 76.12 cM mouse S680-p 1868162500 SDLKPRVsFYFFVTS Collectrin protein stabilization 29570986; 32755395 3 0 0 -LIG1 LIG1 DNA repair, damage; EC 6.5.1.1; Ligase P18858 3978 19q13.33 human S76-p 449246 EEEDEALsPAKGQKP molecular association, regulation; intracellular localization cell growth, altered RFC1(INDUCES); RAD17(DISRUPTS) 12851383; 19223468 6 54 7 regulates DNA replication and repair -AHSA1 AHSA1 Chaperone O95433 10598 14q24.3 human Y223-p 3914778 LTSPEELyRVFTTQE AHSA1 protein degradation; molecular association, regulation; ubiquitination HSP90A(INDUCES) 26235616; 29127155 3 3 6 displaces Tsc1 from Hsp90; increases chaperone activity and reduces expression of CFTR -Ripk3 RIPK3 EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, Ser/Thr (non-receptor); Protein kinase, TKL Q9QZL0 56532 14|14 C3 mouse K469-ub 1883588008 TTASSSAkYDQAQFG activity, induced; ubiquitination apoptosis, inhibited 35800780 1 1 0 Loss of RIPK3-K359 ubiquitin modification prevents increased RIPK3-K469R killing activity, RIPK3-K469ub can restrict cell death by preventing upstream ubiquitylation on K359; activated RIPK3 transitions into a TX-100-insoluble compartmemt, RIPK3 K469 ubiquitylation to limit its cell death-inducing activity, Ripk3 K469R/K469R mice display a moderately reduced capacity to clear Salmonella infection -ACLY ACLY Carbohydrate Metabolism - citrate (TCA) cycle; EC 2.3.3.8; Lyase; Transferase P53396 47 17q21.2 human Y1006-p 1868989001 PATPLLDyALEVEKI Citrate_synt acetylation; enzymatic activity, induced carcinogenesis, induced 32420483 1 0 0 -HASPIN Haspin EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, Other; Protein kinase, Ser/Thr (non-receptor) Q8TF76 83903 17p13.2 human T128-p 3952695 RPPQKCStPCGPLRL molecular association, regulation; phosphorylation cell cycle regulation PLK1(INDUCES) 24413556 1 1 7 Haspin phosphorylation at PLK1 sites -ABI1 Abi-1 Adaptor/scaffold; Motility/polarity/chemotaxis Q8IZP0 10006 10p12.1 human S225-p 1983922 ARLGSQHsPGRTASL molecular association, regulation cell motility, induced; cell motility, altered; cytoskeletal reorganization 21419341; 35293964 2 51 103 -MAP2K4 MKK4 EC 2.7.12.2; KINASE; Kinase, protein; Protein kinase, STE; Protein kinase, dual-specificity (non-receptor) P45985 6416 17p12 human S257-p 447654 ISGQLVDsIAKTRDA Pkinase enzymatic activity, induced 9162092 14 16 45 -PTPRE PTPRE EC 3.1.3.48; Membrane protein, integral; Motility/polarity/chemotaxis; PHOSPHATASE; Receptor protein phosphatase, tyrosine P23469 5791 10q26.2 human N30-ng 1871141701 NETTADSnETTTTSG phosphorylation 31722979 1 0 0 mutants decrease phosphorylation -Ikzf1 Ikaros C2H2-type zinc finger protein; DNA-binding; Transcription factor Q03267 22778 11 A1|11 7.02 cM mouse S167-p 451355 LRHIKLHsGEKPFKC intracellular localization 12464629 2 3 0 -Foxo3 FOXO3A Autophagy; DNA-binding; Oncoprotein; Transcription factor Q9WVH4 56484 10 B2|10 22.79 cM mouse S293-p 472326 QLSKWPGsPTSRSSD transcription, inhibited 27875304 5 19 63 -MAPK7 ERK5 EC 2.7.11.24; KINASE; Kinase, protein; Protein kinase, CMGC; Protein kinase, Ser/Thr (non-receptor) Q13164 5598 17p11.2 human S754-p 21560206 LEEFLNQsFDMGVAD intracellular localization transcription, induced 29483645 1 1 0 oncogenic BRAF induced nuclear localization and transcription -LRRK2 LRRK2 EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, Ser/Thr (non-receptor); Protein kinase, TKL Q5S007 120892 12q12 human T2524-p 15785717 LAEKMRRtSVE____ molecular association, regulation 14-3-3 beta(INDUCES); 14-3-3 sigma(INDUCES); 14-3-3 theta(INDUCES); 14-3-3 zeta(INDUCES); 14-3-3 epsilon(INDUCES); 14-3-3 gamma(INDUCES); 14-3-3 eta(INDUCES) 32317922 2 1 0 -POLD3 POLD3 DNA replication; Nucleotide Metabolism - purine; Nucleotide Metabolism - pyrimidine Q15054 10714 11q13.4 human S458-p 3196808 GKANRQVsITGFFQR CDC27 molecular association, regulation; enzymatic activity, altered PCNA(DISRUPTS) 22148433 1 21 27 S458D mutation results in a loss of POLD3 (aka p68) processivity -TBK1 TBK1 EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, Other; Protein kinase, Ser/Thr (non-receptor) Q9UHD2 29110 12q14.2 human Y354-p 3437786 SSNQELIyEGRRLVL TBK1_ULD enzymatic activity, inhibited; protein conformation 28618271 1 2 1 suppress antiviral defenses -MISP MISP Unknown function Q8IVT2 126353 19p13.3 human S400-p 3205362 LSSDSILsPAPDARA AKAP2_C cytoskeletal reorganization 34023777 1 22 22 -DIAPH2 Diaphanous-2 iso4 Cytoskeletal; Motility/polarity/chemotaxis Q17R91 1730 Xq21.33 human T882-p 18707507 KSADQKTtLLHFIAD FH2 cell cycle regulation; chromatin organization, altered; cytoskeletal reorganization 21397845 1 1 0 mutation of this site disrupts metaphase chromosome alignment -NR1I2 PXR DNA-binding; Nuclear receptor O75469 8856 3q13.33 human S208-p 9730703 QVRKDLCsLKVSLQL molecular association, regulation transcription, altered N-CoR1(INDUCES); FGR(DISRUPTS); RXRA(DISRUPTS) 19617467 1 0 0 inhibits transcription -Kcnj11 Kir6.2 Channel, potassium; Membrane protein, integral; Membrane protein, multi-pass Q61743 16514 7 B3|7 29.66 cM mouse T341-p 2103600 GNTIKVPtPLCTARQ IRK_C activity, induced; protein conformation 18280666 1 0 0 -App APP iso2 Apoptosis; Cell surface; Membrane protein, integral; Receptor, misc.; Transcription factor P12023-2 11820 16 C3.3|16 46.92 cM mouse Y682-p 448202 SKMQQNGyENPTYKF APP_amyloid molecular association, regulation GRB2(INDUCES); SHC1(INDUCES) 15054097; 27325702 14 20 864 -HNRNPC hnRNP C1/C2 RNA splicing; RNA-binding; Spliceosome P07910 3183 14q11.2 human S260-p 448833 SEGGADDsAEEGDLL molecular association, regulation RNA(NOT_REPORTED) 15687492 2 75 87 -PLIN2 perilipin 2 Endoplasmic reticulum Q99541 123 9p22.1 human Y232-p 1873650100 TKLHSRAyQQALSRV Perilipin protein degradation; molecular association, regulation autophagy, induced; cell growth, induced; apoptosis, inhibited HSC70(INDUCES) 34077757 1 1 0 -SREBF1 SREBP-1 DNA-binding; Membrane protein, integral; Membrane protein, multi-pass; Transcription factor P36956 6720 17p11.2 human T426-p 467200 TEVEDTLtPPPSDAG protein degradation; molecular association, regulation; ubiquitination; phosphorylation transcription, induced FBXW7(INDUCES) 16825193; 19126544; 22384276; 26759235 6 3 0 -PRKD1 PRKD1 Autophagy; EC 2.7.11.13; KINASE; Kinase, protein; Motility/polarity/chemotaxis; Protein kinase, CAMK; Protein kinase, Ser/Thr (non-receptor) Q15139 5587 14q12 human S219-p 455755 VSTIRTSsAELSTSA molecular association, regulation 14-3-3 beta(INDUCES) 15755722 1 3 0 -SMAD3 SMAD3 DNA-binding; Nuclear receptor co-regulator; Transcription factor P84022 4088 15q22.33 human T179-p 451177 PQSNIPEtPPPGYLS molecular association, regulation; intracellular localization; activity, inhibited cell cycle regulation; carcinogenesis, induced; cell motility, induced; transcription, induced; signaling pathway regulation; transcription, altered; transcription, inhibited; cell growth, altered NEDD4L(INDUCES); PIN1(INDUCES) 10197981; 15241418; 16156666; 19914168; 19917253; 19920136; 20736297; 26297431; 33051597 15 0 0 TGF-beta induced epithelial-to-mesenchymal transition (EMT) ; TGFB1 signaling -MYH7 MYH7 Motility/polarity/chemotaxis; Motor P12883 4625 14q11.2 human K34-ac 15292419 QTRPFDLkKDVFVPD Myosin_N protein conformation 35502901 0 1 56 -Vasp VASP Cytoskeletal; Motility/polarity/chemotaxis P70460 22323 7|7 A3 mouse S153-p 448379 EHMERRVsNAGGPPA molecular association, regulation cytoskeletal reorganization ACTB(DISRUPTS); Abl iso4(INDUCES) 12087107; 21795685 55 4 0 Abolishes actin polymerization -Dlc1 DLC1 GAP; GAP, Rac/Rho; Tumor suppressor Q9R0Z9 50768 8 A4|8 23.05 cM mouse S432-p 15500000 KELKRRNsSSSLSSR activity, induced; molecular association, regulation; activity, inhibited carcinogenesis, inhibited; cell growth, inhibited; cytoskeletal reorganization; cell motility, inhibited tensin 2(INDUCES); DLC1(INDUCES) 23511482 2 5 2 Increased GAP activity further inhibiting RhoA activity -CALD1 Caldesmon Actin-binding P12957 373965 chicken S631-p 15668100 AHTTAVVsKIDSRLE Caldesmon molecular association, regulation Caldesmon(DISRUPTS) 20858431 0 3 0 enhances effect of S672 and S702 phosphorylation to weaken interaction -Ncf1 p47phox EC 1.-.-.-; Oxidoreductase Q09014 17969 5 G2|5 74.47 cM mouse S329-p 449404 QDTYRRNsVRFLQQR NECFESHC intracellular localization; enzymatic activity, induced 30483268 22 0 0 NADPH oxidase activation and superoxide production induced further aggravating liver I/R injury -Neurod1 NEUROD1 DNA-binding; Transcription factor Q60867 18012 2 C3|2 47.58 cM mouse S274-p 465680 PSFDGPLsPPLSING Neuro_bHLH molecular association, regulation transcription, induced E2A iso2(INDUCES) 12810726 3 0 0 -Drgx DRGX DNA-binding Q8BYH0 107751 14|14 B mouse T110-p 62925706 KEPMAEVtPPPVRNI protein conformation transcription, altered 28049756 1 1 0 -Git1 GIT1 GAP; GAP, ARF; Motility/polarity/chemotaxis Q9Z272 83709 10q24 rat Y293-p 15702201 EELAMDVyDEVDRRE GIT_SHD molecular association, regulation eNOS(INDUCES) 24764294 4 1 0 -GPKOW GPKOW RNA-binding Q92917 27238 Xp11.23 human S27-p 10405008 SFGFTRTsARRRLAD molecular association, regulation RNA(DISRUPTS) 21880142 1 2 1 regulates pre-mRNA processing -HDAC2 HDAC2 DEACETYLASE; Deacetylase; EC 3.5.1.98; Nuclear receptor co-regulator; Transcription, coactivator/corepressor Q92769 3066 6q21 human S411-p 13373500 KRISIRAsDKRIACD molecular association, regulation; acetylation; enzymatic activity, inhibited p53(INDUCES); HDAC1(INDUCES) 20388487 3 3 0 -BMAL1 BMAL1 DNA-binding; Transcription factor Q9I8T7 374115 chicken T534-p 448633 SPLNITStPPPDTSS activity, inhibited transcription, inhibited 11687575 2 0 0 -CSRP2 CSRP2 Cell development/differentiation Q16527 1466 12q21.2 human Y62-p 470027 EIYCKSCyGKKYGPK LIM intracellular localization transcription, altered 12771930 1 0 0 Nuclear translocation. -Syn1 SYN1 Vesicle P09951 24949 Xq11 rat S603-p 450236 AGPIRQAsQAGPGPR intracellular localization 19896987 21 10 11 -CAMK2D CAMK2D EC 2.7.11.17; KINASE; Kinase, protein; Protein kinase, CAMK; Protein kinase, Ser/Thr (non-receptor) Q13557 817 4q26 human T337-p 484561 STESSNTtIEDEDVK enzymatic activity, altered 34391760 1 37 5 -Naca NACA iso2 Motility/polarity/chemotaxis; Transcription, coactivator/corepressor Q60817 17938 10|10 D3 mouse K127-sm 31014809 YIVFGEAkIEDLSQQ NAC molecular association, regulation transcription, inhibited TXLNG(INDUCES); HDAC2(INDUCES) 24375853 1 0 0 -BCAR1 P130Cas Adaptor/scaffold; Motility/polarity/chemotaxis P56945 9564 16q23.1 human Y410-p 448720 GVVDSGVyAVPPPAE carcinogenesis, induced; cell motility, inhibited 35081345 18 23 126 -ATXN3 ataxin-3 DEUBIQUITINASE; DNA repair, damage; EC 3.4.19.12; Protease; Transcription regulation; Ubiquitin-specific protease P54252 4287 14q32.12 human S12-p 53998806 FHEKQEGsLCAQHCL Josephin enzymatic activity, inhibited 26880203 1 1 0 phosphorylation protects against toxicity of pathogenic pathways mediated by polyglutamine-expanded ataxin-3 -Stat3 STAT3 DNA-binding; Motility/polarity/chemotaxis; Nuclear receptor co-regulator; Transcription factor P42227 20848 11 D|11 63.82 cM mouse S727-p 448191 NTIDLPMsPRTLDSL activity, induced; molecular association, regulation; intracellular localization; phosphorylation carcinogenesis, induced; cell motility, induced; transcription, induced; signaling pathway regulation; transcription, altered; neural plasticity; cell growth, induced; cell differentiation, induced; apoptosis, inhibited; cytoskeletal reorganization; transcription, inhibited; cell growth, altered PDGFRA(INDUCES); GRIM-19(INDUCES); ANXA1(INDUCES); PIN1(INDUCES) DNA(INDUCES); DNA(DISRUPTS) 11278353; 12049654; 12684046; 14673173; 15096606; 15705584; 16205632; 16247467; 16418226; 17563747; 21575863; 21738764; 25584415; 26479789; 26573296; 27050520; 28356390; 33788814; 34124936; 34380027; 34507993; 35732128; 35806005; 35986103; 36688918; 37440406 227 57 67 regulates IFN signaling -FOXO4 FOXO4 DNA-binding; Oncoprotein; Transcription factor P98177 4303 Xq13.1 human S265-p 231166707 PRSSSNAsSVSTRLS protein degradation; phosphorylation 28945225 1 0 0 26 S proteasome-mediated FOXO4 proteolysis in the nuclei of RAS mutant colon cancer cells -CDC25A CDC25A EC 3.1.3.48; Motility/polarity/chemotaxis; PHOSPHATASE; Protein phosphatase, dual-specificity P30304 993 3p21.31 human S279-p 449129 VLKRPERsQEESPPG M-inducer_phosp protein degradation 12676583 1 0 0 -SIAH2 SIAH2 EC 6.3.2.-; EC 6.3.2.19; Ligase; Transcription, coactivator/corepressor; UBIQUITIN LIGASE; Ubiquitin conjugating system; Ubiquitin ligase O43255 6478 3q25.1 human T279-p 1872043500 RRLTWEAtPRSIHDG Sina protein stabilization carcinogenesis, induced; cell motility, induced; cell growth, induced 33536006 1 0 0 -PTK2 FAK EC 2.7.10.2; KINASE; Kinase, protein; Protein kinase, TK; Protein kinase, tyrosine (non-receptor) Q00944 396416 chicken S722-p 447962 PSRPGYPsPRSSEGF molecular association, regulation; enzymatic activity, inhibited cell motility, altered PPP1CA(INDUCES); P130Cas(DISRUPTS) 11160818; 15975092 9 18 0 -HRH1 H1R GPCR, family 1; Membrane protein, integral; Membrane protein, multi-pass; Receptor, GPCR P35367 3269 3p25.3 human S396-p 453404 FTWKRLRsHSRQYVS 7tm_1 receptor desensitization, altered; activity, inhibited 15107581; 15328002 2 0 0 S396 phosphorylation had an inhibitory effect on S398-mediated receptor downregulation. -GAD2 GAD2 Amino Acid Metabolism - alanine, aspartate and glutamate; Carbohydrate Metabolism - butanoate; EC 4.1.1.15; Lyase; Other Amino Acids Metabolism - beta-alanine; Other Amino Acids Metabolism - taurine and hypotaurine Q05329 2572 10p12.1 human S6-p 12523303 __MASPGsGFWSFGS enzymatic activity, induced transcription, induced 31182548 2 1 0 -Gli2 GLI2 C2H2-type zinc finger protein; Oncoprotein; Transcription factor Q0VGT2 14633 1 E2.3|1 52.17 cM mouse K716-sm 25352003 VHRFEQLkREKLKSL molecular association, regulation transcription, inhibited HDAC5(INDUCES) 22549777 1 0 0 -Ikbkg IKKG Adaptor/scaffold; Protein kinase, regulatory subunit O88522 16151 X|X A7.3 mouse S369-p 448798 LPAPAHHsFHLALSN activity, inhibited transcription, induced; transcription, altered 11971901; 36309088 5 2 6 -H3c1 H3 DNA-binding P68433 360198 13|13 A3.1 mouse K27-me 467241 LATKAARkSAPATGG Histone transcription, inhibited 19233846 11 3 0 p16 Ink4a/ p19Arf locus -MYBPC3 MYBPC3 Myosin-binding Q14896 4607 11p11.2 human S275-p 471079 LSAFRRTsLAGGGRR cytoskeletal reorganization 20018870 25 9 14 regulation of cardiac myofilament function -APP APP Apoptosis; Cell surface; Membrane protein, integral; Receptor, misc.; Transcription factor P05067 351 21q21.3 human K687-ne 12124805 GYEVHHQkLVFFAED Beta-APP transcription, inhibited Fe65(DISRUPTS) 18096514 1 0 0 -FOSL1 FRA1 DNA-binding; Transcription factor P15407 8061 11q13.1 human K116-ac 40663031 RVRRERNkLAAAKCR bZIP_1 molecular association, regulation cell growth, inhibited; transcription, inhibited DNA(DISRUPTS) 30804456 1 0 5 NANOG is a key downstream effector of IL-6/STAT3/FRA1 -Pfkfb2 PFKFB2 Carbohydrate Metabolism - fructose and mannose; EC 2.7.1.105; EC 3.1.3.46; Kinase, other; Motility/polarity/chemotaxis; Phosphatase (non-protein) Q9JJH5 24640 13q13 rat S469-p 448460 PVRMRRNsFTPLSSS enzymatic activity, induced 11069105 10 60 333 -Kcnj11 Kir6.2 Channel, potassium; Membrane protein, integral; Membrane protein, multi-pass Q61743 16514 7 B3|7 29.66 cM mouse S372-p 22874702 RGPLRKRsVAVAKAK receptor internalization, induced 22207763 1 2 0 Kir6.2\SUR2B channels activity inhibited -PLEK pleckstrin Lipid-binding P08567 5341 2p14 human S117-p 451306 ARKSTRRsIRLPETI activity, induced 7559487 2 13 146 -SMARCC2 SMARCC2 DNA-binding; Transcription, coactivator/corepressor Q8TAQ2 6601 12q13.2 human S969-p 15707400 PPALPPGsQPIPPTG molecular association, regulation chromatin organization, altered MCPH1(INDUCES) 19525936 1 0 0 interaction enhanced after DNA damage with ionizing radiation -Trhr TRHR GPCR, family 1; Membrane protein, integral; Membrane protein, multi-pass; Receptor, GPCR Q01717 25570 7q31 rat T371-p 465593 STELDDItVTDTYVS receptor internalization, altered 11278484 3 0 0 S383, T365, T371 are important for the receptor internalization -LYN LYN EC 2.7.10.2; KINASE; Kinase, protein; Oncoprotein; Protein kinase, TK; Protein kinase, tyrosine (non-receptor) P07948 4067 8q12.1 human Y508-p 447624 YTATEGQyQQQP___ molecular association, regulation; enzymatic activity, inhibited; enzymatic activity, induced carcinogenesis, induced; cell growth, induced; apoptosis, inhibited STAT3(INDUCES); PAG(INDUCES) 15626731; 18070987 27 48 1560 -Braf BRAF EC 2.7.11.1; KINASE; Kinase, protein; Oncoprotein; Protein kinase, Ser/Thr (non-receptor); Protein kinase, TKL F1M9C3 114486 4q22 rat S463-p 447803 PQRERKSsSSSSSTE enzymatic activity, inhibited; enzymatic activity, induced cell differentiation, altered 17074813 7 1 32 activates the B3-Raf9b isoform ; inhibits activity of the B2-Raf8b isoform -FYN Fyn EC 2.7.10.2; KINASE; Kinase, protein; Oncoprotein; Protein kinase, TK; Protein kinase, tyrosine (non-receptor) P06241 2534 6q21 human Y420-p 447882 RLIEDNEyTARQGAK PK_Tyr_Ser-Thr molecular association, regulation carcinogenesis, induced; DNA repair, induced STEP(INDUCES) 11983687; 29989005 31 94 3048 -IFNAR1 IFNAR1 Membrane protein, integral; Receptor, cytokine P17181 3454 21q22.11 human Y466-p 450029 VFLRCINyVFFPSLK protein stabilization; molecular association, regulation; receptor internalization, inhibited; phosphorylation transcription, induced STAT2(INDUCES); STAT1(INDUCES) 12220192; 23129613; 8605876; 9121453 5 0 0 virally induced and negatively regulated by PTP1B dephosphorylatyion of human Y466 -CLOCK CLOCK ACETYLTRANSFERASE; Acetyltransferase; DNA-binding; EC 2.3.1.48; Transcription factor O15516 9575 4q12 human K842-sm 27992506 DSLPDPSkVQPQ___ molecular association, regulation cell cycle regulation; cell growth, induced; transcription, induced; signaling pathway regulation ER-alpha(INDUCES) 23160374 1 0 0 induces ER-alpha signaling -IRF3 IRF3 DNA-binding; Transcription factor Q14653 3661 19q13.33 human S123-p 4712212 DFSQPDTsPDTNGGG molecular association, regulation transcription, inhibited IRF7(INDUCES) 23685991; 24275658 2 11 0 Formation of IRF3:IRF7 dimers -Plcg2 PLCG2 Carbohydrate Metabolism - inositol phosphate; EC 3.1.4.11; Motility/polarity/chemotaxis; Phospholipase P24135 29337 19q12 rat Y1197-p 447938 LESEEELySSCRQLR enzymatic activity, induced 11507089 4 1 87 -PYGM PYGM Carbohydrate Metabolism - starch and sucrose; EC 2.4.1.1; Endoplasmic reticulum; Phosphorylase; Transferase P00489 100008972 rabbit S15-p 449838 QEKRKQIsVRGLAGV enzymatic activity, induced 270711; 5442160 5 7 1 -EHD3 EHD3 Q9NZN3 30845 2p23.1 human K315-sm 49176400 AYIISSLkKEMPSVF DUF5600 receptor recycling, induced; intracellular localization endocytosis, altered 26226295 1 0 0 tubulation of the endocytic recycling compartment (ERC) membranes and efficient recycling -Insr INSR EC 2.7.10.1; KINASE; Kinase, protein; Membrane protein, integral; Protein kinase, TK; Protein kinase, tyrosine (receptor) P15127 24954 12p12 rat T1188-p 14574883 MTRDIYEtDYYRKGG PK_Tyr_Ser-Thr enzymatic activity, inhibited; phosphorylation signaling pathway regulation 33411692 1 4 52 inhibits PDE3B activity, induces PKA activity, induces phosphorylation of perilipin, HSL, and ATGL, leads to insulin resistance -RASSF1 RASSF1 iso2 Tumor suppressor Q9NS23-2 11186 3p21.31 human T202-p 483999 GTSVRRRtSFYLPKD RA protein degradation; molecular association, regulation; ubiquitination cell cycle regulation TUBA1A(DISRUPTS) 17563743; 21874044 2 3 1 APC/C-dependent ubiquitination of RASSF1 -EIF2S2 eIF2-beta Translation; Translation initiation P20042 8894 20q11.22 human S67-p 450072 DTRKKDAsDDLDDLN translation, altered; cell growth, altered 16225457 3 38 0 -DBN1 DBN1 iso3 Actin-binding; Cytoskeletal; Motility/polarity/chemotaxis Q16643-3 1627 5q35.3 human S342-p 485840 SSSSSSSsPPRTPFP intracellular localization cytoskeletal reorganization 24637538 1 9 0 Phospho-drebrin was localized at the distal part of total drebrin in the growth cone. -MARK3 MARK3 EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, CAMK; Protein kinase, Ser/Thr (non-receptor) P27448 4140 14q32.32-q32.33 human T211-p 450314 TVGGKLDtFCGSPPY Pkinase enzymatic activity, induced 12879020 3 46 34 -TCF7L2 TCF7L2 Apoptosis; Cell cycle regulation; Cell development/differentiation; DNA-binding; Motility/polarity/chemotaxis; Transcription factor Q9NQB0 6934 10q25.2-q25.3 human T201-p 11499003 PHHVHPLtPLITYSN CTNNB1_binding molecular association, regulation DNA(DISRUPTS) 12556497 1 0 0 Beta-catenin-TCF7L2 complex DNA binding -Ybx1 YB-1 RNA processing; RNA splicing; RNA-binding; Transcription factor P62961 500538 5q36 rat S100-p 455636 NPRKYLRsVGDGETV CSD intracellular localization transcription, induced 27080258 23 33 2 nuclear localization, Phospho-YB-1(Ser100) is necessary for expression of select FSH target genes -WWTR1 TAZ Oncoprotein; Transcription, coactivator/corepressor Q9GZV5 25937 3q25.1 human S105-p 3211881 TGAGAAGsPAQQHAH protein degradation; activity, inhibited carcinogenesis, inhibited; cell growth, inhibited; cell motility, inhibited; transcription, inhibited 26183396; 26375055 2 6 13 -Sox2 SOX2 Cell development/differentiation; DNA-binding; Transcription factor P48432 20674 3 A3|3 16.93 cM mouse K75-ac 8537503 MHNSEISkRLGAEWK HMG_box protein degradation; molecular association, regulation; ubiquitination; intracellular localization transcription, altered Exportin-1(INDUCES) 19591226 1 1 1 promotes nuclear export -Stat2 STAT2 DNA-binding; Transcription factor Q9WVL2 20847 10 D3|10 76.5 cM mouse T403-p 1869973803 IWDFGFLtLVEQRAV STAT_bind signaling pathway regulation 32759968 2 1 0 IFN-1 signaling; regulates antiviral defense -Lime1 LIME1 Adaptor/scaffold; Membrane protein, integral Q9EQR5 72699 2|2 H4 mouse Y242-p 454608 PLGSDVEyEAINLRG LIME1 activity, induced; molecular association, regulation LYN(INDUCES); Lck(INDUCES) 14610044; 16249387 3 1 17 -Dapk2 DAPK2 EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, CAMK; Protein kinase, Ser/Thr (non-receptor) Q8VDF3 13143 9 C|9 35.75 cM mouse T369-p 487231 HPRRRSStS______ molecular association, regulation 14-3-3 epsilon(INDUCES); 14-3-3 gamma(INDUCES) 26047703 2 1 1 -Epha4 EphA4 EC 2.7.10.1; KINASE; Kinase, protein; Membrane protein, integral; Protein kinase, TK; Protein kinase, tyrosine (receptor) Q03137 13838 1 C4|1 39.55 cM mouse Y779-p 450858 EDDPEAAyTTRGGKI PK_Tyr_Ser-Thr enzymatic activity, induced cell cycle regulation; cell motility, altered 10848605; 18515860 2 33 700 -MAVS MAVS Adaptor/scaffold; Membrane protein, integral Q7Z434 57506 20p13 human K311-ub 89115601 PVNTVALkVPANPAS protein degradation; molecular association, regulation autophagy, induced MAVS(INDUCES) 27992402; 31304625 2 1 0 RNF34-induced K63-K27 ubiquitination transition promoting autophagic degradation of MAVS aggregates -MDM4 MDM4 EC 6.3.2.-; Ligase; UBIQUITIN LIGASE; Ubiquitin conjugating system; Ubiquitin ligase O15151 4194 1q32.1 human S367-p 457676 PDCRRTIsAPVVRPK protein degradation; protein stabilization; molecular association, regulation; ubiquitination; intracellular localization; phosphorylation transcription, induced; transcription, inhibited; cell growth, altered 14-3-3 zeta(INDUCES); 14-3-3 epsilon(INDUCES); p53(DISRUPTS); MDM2(DISRUPTS); USP7(DISRUPTS); 14-3-3 beta(INDUCES); 14-3-3 theta(INDUCES); 14-3-3 gamma(INDUCES); MDM2(INDUCES); CK1A(DISRUPTS) 15788536; 16163388; 16227609; 16511560; 16511572; 16943424; 18356162; 19432880; 19808970; 22120712; 23028042; 23277204; 24190973; 27114532 21 11 2 -SKAP1 SKAP55 Adaptor/scaffold; Motility/polarity/chemotaxis Q86WV1 8631 17q21.32 human Y298-p 460297 KGVDYASyYQGLWDC molecular association, regulation cell adhesion, altered SLP76(DISRUPTS) 16461356 1 0 0 -Pdx1 PDX1 DNA-binding; Transcription factor P52946 18609 5 G3|5 86.84 cM mouse S61-p 458401 LGSLEQGsPPDISPY protein degradation 16407209 3 1 0 -Mag MAG Cell adhesion; Membrane protein, integral P07722 29409 1q21 rat Y620-p 451280 LTEELAEyAEIRVK_ molecular association, regulation PLCG1(INDUCES); Fyn(INDUCES) 7525550 1 0 0 L-MAG but not S-MAG expressed in fibroblasts was capable of binding PLCgamma SH2 domains. -RAP1B RAP1B G protein; G protein, monomeric; G protein, monomeric, Ras P61224 5908 12q15 human S179-p 451799 PGKARKKsSCQLL__ activity, induced; molecular association, regulation; protein conformation RAP1GDS1(DISRUPTS) 19651783; 27760305 8 1 0 inhibits the prenylation of Rap1B -MAP2K1 MEK1 EC 2.7.12.2; KINASE; Kinase, protein; Protein kinase, STE; Protein kinase, dual-specificity (non-receptor) P29678 100009316 rabbit S218-p 448514 VSGQLIDsMANSFVG Pkinase enzymatic activity, induced 7873542 124 13 83 in vitro -MYLK smMLCK EC 2.7.11.18; KINASE; Kinase, protein; Protein kinase, CAMK; Protein kinase, Ser/Thr (non-receptor) P29294 100009143 rabbit S1005-p 455821 GLSGRKSsTGSPTSP activity, induced; intracellular localization 11346659; 12176732 7 17 8 -KAT5 Tip60 ACETYLTRANSFERASE; Acetyltransferase; EC 2.3.1.48; Nuclear receptor co-regulator; Nucleolus Q92993 10524 11q13.1 human K189-ac 52498001 AQPGRKRkSNCLGTD protein degradation; intracellular localization apoptosis, altered 25301942 1 0 0 HDAC3 increased the TIP60 half-life, and the ubiquitination level of TIP60, nuclear localization, cytoplasm and nucleus with HDAC3 expressed, TIP60 deacetylation increases its resistance to apoptosis -CAV2 caveolin-2 Adaptor/scaffold; Motility/polarity/chemotaxis P51636 858 7q31.2 human S36-p 469561 DPEKFADsDQDRDPH Caveolin activity, induced 12743374 3 7 4 formation of caveolae -CFTR CFTR Channel, chloride; EC 3.6.3.49; Hydrolase; Membrane protein, integral; Membrane protein, multi-pass; Transporter; Transporter, ABC family P13569 1080 7q31.2 human T1471-p 21440502 IAALKEEtEEEVQDT protein degradation; intracellular localization; activity, inhibited 21930781 2 1 0 Regulates CFTR trafficking -Bach2 BACH2 DNA-binding; Transcription factor P97303 12014 4|4 A5 mouse K275-sm 2798317 GLPMGQIkSEPPSEE intracellular localization transcription, inhibited 15060166 2 0 0 formation of PML bodies -FLNA FLNA Actin-binding; Motility/polarity/chemotaxis; Nuclear receptor co-regulator P21333 2316 Xq28 human S1533-p 478649 GDEEVPRsPFKVKVL Filamin cell motility, induced; cytoskeletal reorganization 25445790 2 17 9 cell separation following mitosis, AAA mutant has defects in cell motility -PDCD4 PDCD4 Apoptosis; Tumor suppressor Q53EL6 27250 10q25.2 human R110-me 1873375608 RSRSGKGrGLPKKGG enzymatic activity, induced carcinogenesis, induced; cell growth, induced 21700716 1 0 0 Coexpression with PRMT5 with PDCD4-R110 and catalytic activity of both, are necessary for enhanced tumor growth. -FHIP2B FHIP2B Q86V87 64760 8p21.3 human S325-p 40642200 GISWRLPsAPSDEAS RAI16-like molecular association, regulation 14-3-3 theta(INDUCES) 25900241 1 0 0 -WASL N-WASP Adaptor/scaffold; Motility/polarity/chemotaxis Q95107 cow Y256-p 450253 RETSKVIyDFIEKTG PBD cytoskeletal reorganization 16199863 9 65 1373 required for formation of Shigella-induced actin comet tails -HMGA1 HMGA1 DNA-binding P17096 3159 6p21.31 human K71-ac 458953 SKNKGAAkTRKTTTT molecular association, regulation; acetylation transcription, induced NFkB-p105(INDUCES); ATF-2(INDUCES); NFkB-p65(INDUCES) 11498590; 9809067 4 2 0 optimum activation of transcription without effect on postinduction turnoff ; enhanceosome assembly, inhibits acetylation at K65 -MACF1 ACF7 Actin-binding; Cytoskeletal; Motility/polarity/chemotaxis Q9UPN3 23499 1p34.3 human S7330-p 468158 RASSRRGsDASDFDL intracellular localization cell motility, induced; cytoskeletal reorganization 21295697 1 24 5 inhibits localization along microtubules, alters organization of microtubules, regulates skin wound repair, SC migration -NFKB2 NFkB-p100 DNA-binding; Oncoprotein; Transcription factor Q00653 4791 10q24.32 human S711-p 25234803 PLPSPPTsDSDSDSE protein degradation; ubiquitination carcinogenesis, induced; cell growth, induced; apoptosis, inhibited; transcription, induced FBXW7(INDUCES) 22388891; 22864569 2 0 0 -CGAS cGAS EC 2.7.7.86 Q8N884 115004 6q13 human K394-sm 62952701 LNNHGKSkTCCENKE enzymatic activity, inhibited transcription, inhibited; signaling pathway regulation DNA(DISRUPTS) 28095500 1 0 0 regulation of STING signaling pathway -NFATC4 NFAT3 DNA-binding; Transcription factor Q14934 4776 14q12 human S285-p 13419501 SSASPALsRRGSLGE transcription, altered 17213202 1 1 0 -SLCO1B1 SLCO1B1 Membrane protein, integral; Membrane protein, multi-pass; Transporter; Transporter, SLC family Q9Y6L6 10599 12p12.1 human Y640-p 1872500200 RVSSLVLyIILIYAM activity, induced 33664059 1 1 0 -OCLN occludin Cell adhesion; Membrane protein, integral; Membrane protein, multi-pass; Motility/polarity/chemotaxis Q16625 100506658 5q13.2 human Y474-p 3666920 YREESEEyMAAADEY Occludin_ELL molecular association, regulation cell motility, altered PIK3R1(INDUCES) 20152177 1 0 2 -ERF ERF DNA-binding; Transcription factor P50548 2077 19q13.2 human T526-p 448321 GEAGGPLtPRRVSSD intracellular localization cell cycle regulation; transcription, induced 10330152; 14729966; 7588608 4 33 136 -Ksr2 KSR2 EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, Ser/Thr (non-receptor); Protein kinase, TKL Q3UVC0 333050 5|5 F mouse S475-p 4721669 ARLVRTEsVPCDINN molecular association, regulation; intracellular localization 14-3-3 beta(INDUCES) 19560418 1 7 3 -Cacna1e CACNA1E Channel, calcium; Membrane protein, integral; Membrane protein, multi-pass Q07652 54234 13q21 rat S369-p 455593 RRATIKRsRTEAMTR activity, induced 15840578 1 0 0 potentiation of Ca(2+) currents -CTNNB1 CTNNB1 Actin-binding; Cell adhesion; Motility/polarity/chemotaxis; Nuclear receptor co-regulator; Oncoprotein; Transcription factor P35222 1499 3p22.1 human S179-p 23096710 AVMVHQLsKKEASRH molecular association, regulation CEACAM1(INDUCES) 34656562 1 6 1 -KCNN4 KCNN4 Channel, potassium; Membrane protein, integral; Membrane protein, multi-pass O15554 3783 19q13.31 human T329-p 452144 AWMFYKHtRRKESHA CaMBD activity, inhibited 12029379 2 0 0 inhibition during prolonged PMA treatment (not short-term) -Foxo1 FOXO1A DNA-binding; Nuclear receptor co-regulator; Oncoprotein; Transcription factor Q9R1E0 56458 3 C|3 23.19 cM mouse S499-p 4911902 NVMMGPNsVMPAYGS FOXO_KIX_bdg transcription, inhibited 12724332 1 0 0 -Acaca ACC1 Carbohydrate Metabolism - propanoate; Carbohydrate Metabolism - pyruvate; EC 6.3.4.14; EC 6.4.1.2; Ligase; Lipid Metabolism - fatty acid biosynthesis P11497 60581 10q26 rat S1200-p 448290 IPTLNRMsFASNLNH ACC_central enzymatic activity, inhibited 7915280 3 4 2 -HSP90AB1 HSP90B Chaperone; Heat shock protein P08238 3326 6p21.1 human T89-p 18495101 RTLTLVDtGIGMTKA HATPase_c molecular association, regulation; intracellular localization cell growth, induced; transcription, induced AR(DISRUPTS) 30992362 2 2 1 -ESR1 ER-alpha DNA-binding; Nuclear receptor; Transcription factor P03372 2099 6q25.1-q25.2 human S282-p 6048401 EGRGEVGsAGDMRAA activity, inhibited transcription, altered 20043841 4 1 0 inhibits ligand-independent activation of ER-alpha -PARP1 PARP1 DNA repair, damage; EC 2.4.2.30; Nuclear envelope; Nuclear receptor co-regulator; Nucleolus; Transferase P09874 142 1q42.12 human Y907-p 53332701 MVSKSANyCHTSQGD PARP molecular association, regulation; enzymatic activity, induced DNA repair, induced; carcinogenesis, induced PARP2(DISRUPTS) 26779812; 33520371 3 0 0 -CAB2 CACNB2 Channel, calcium P54288 100009277 rabbit S322-p 2024725 ERSNTRSsLAEVQSE Guanylate_kin molecular association, regulation AHNAK(INDUCES) 22497893 1 1 0 -Atat1 ATAT1 iso2 ACETYLTRANSFERASE; Acetyltransferase; EC 2.3.1.108 Q8K341-2 73242 17|17 B1 mouse K221-ac 27581503 SSDREFLkVAVEPPW enzymatic activity, induced 23275437 1 1 0 -EIF4B EIF4B RNA-binding; Translation; Translation initiation P23588 1975 12q13.13 human S406-p 470374 RPRERHPsWRSEETQ molecular association, regulation cell cycle regulation; apoptosis, inhibited; translation, induced eIF3-alpha(INDUCES) 27528663 8 50 670 regulates protein synthesis during mitosis -SNCAIP SNCAIP Vesicle Q9Y6H5 9627 5q23.2 human S211-p 2873902 MAPFCVLsPVKSPHL molecular association, regulation PIN1(INDUCES) 16365047 1 0 0 -GNB1 G-beta 1 G protein; G protein, heterotrimeric; G protein, heterotrimeric beta P62873 2782 1p36.33 human K23-ub 7250962 NQIRDARkACADATL phosphorylation signaling pathway regulation 34342229 1 6 54 KCTD2/KCTD5-CUL3-RING E3 ligase promotes cAMP signaling in cancer-derived cell lines -POLH POLH DNA repair, damage; EC 2.7.7.7; Transferase Q9Y253 5429 6p21.1 human K224-sm 1877365904 SHNKVLAkLACGLNK IMS intracellular localization; enzymatic activity, inhibited 32350109 1 1 0 -Gja4 GJA4 Cell adhesion; Membrane protein, integral; Membrane protein, multi-pass P28235 14612 4 D2.2|4 61.47 cM mouse S325-p 1870939902 KSPSRPNsSASKKQY cell cycle regulation; apoptosis, induced 30736283 0 1 0 -PAK2 PAK2 EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, STE; Protein kinase, Ser/Thr (non-receptor) Q13177 5062 3q29 human T402-p 448300 PEQSKRStMVGTPYW Pkinase activity, induced; protein conformation; enzymatic activity, induced cell cycle regulation 20209159; 21098037; 25466889; 26078008 15 2 11 -Apex1 APE1 DNA repair, damage; DNA-binding; Deoxyribonuclease; EC 4.2.99.18; Endoplasmic reticulum; Hydrolase; Lyase; Nuclear receptor co-regulator; Nucleolus; Transcription, coactivator/corepressor P28352 11792 14 C1|14 26.3 cM mouse T232-p 14645304 NKKNAGFtPQERQGF Exo_endo_phos enzymatic activity, inhibited apoptosis, altered 20473298 2 0 0 in vitro and in MPP-treated neurons -GAP43 GAP43 Cell surface P06836 281777 cow S41-p 448719 AATKIQAsFRGHITR IQ protein processing 16212546; 17326767 14 9 5 inhibits cleavage by m-calpain; blocks proteolytic cleavage by m-calpain -Syne1 SYNE1 Actin-binding; Membrane protein, integral; RNA-binding Q6ZWR6 64009 10|10 A1 mouse S1389-p 30310302 EFSKRTEsIATQAEN receptor internalization, induced; molecular association, regulation; intracellular localization cytoskeletal reorganization ACTB(INDUCES) 24191017 1 1 0 localization to dendritic spines, GluA2 internalization -MAPK7 ERK5 EC 2.7.11.24; KINASE; Kinase, protein; Protein kinase, CMGC; Protein kinase, Ser/Thr (non-receptor) Q13164 5598 17p11.2 human S496-p 455518 SRLRDGPsAPLEAPE activity, inhibited; enzymatic activity, induced apoptosis, induced; transcription, inhibited 22267842; 30586719; 34619528 10 2 0 inhibits CHIP-Ubiquitin ligase activity; endothelial inflammation; induces PARP activity -Slc9a3 NHE3 Membrane protein, integral; Membrane protein, multi-pass; Transporter; Transporter, SLC family P26433 24784 1p11 rat S605-p 450900 SLEQRRRsIRDTEDM molecular association, regulation; intracellular localization; activity, inhibited SYT1(INDUCES) 11937500; 19926819; 21593184; 9933588 13 1 0 -KDELR1 KDELR1 Endoplasmic reticulum; Membrane protein, integral; Membrane protein, multi-pass P24390 10945 19q13.33 human S209-p 455669 VLKGKKLsLPA____ intracellular localization 14517323 1 0 0 -P2rx2 P2X2 Channel, cation; Channel, ligand-gated; Membrane protein, integral; Membrane protein, multi-pass P49653 114115 12q16 rat S363-p 1050143100 MNKNKLYsHKKFDKV P2X_receptor receptor desensitization, inhibited 29641486 1 0 0 constitutive phosphorylation blocks intracellular calcium-dependent facilitation of receptor desensitization -SAMHD1 SAMHD1 EC 3.1.4.- Q9Y3Z3 25939 20q11.23 human K622-ub 1878023500 KSRVQLFkDDPM___ protein degradation 31797533 1 1 0 -PTTG1 Securin Cell cycle regulation; Oncoprotein O95997 9232 5q33.3 human S31-p 30977068 LKLGSGPsIKALDGR Securin protein degradation; ubiquitination; enzymatic activity, induced chromatin organization, altered 24781523 1 6 0 1) Phosphorylation of securing leads to premature activation of separase. 2) Prevention of securin phosphorylation leads to impaired chromosome segregation and thereby leads to DNA damage. -OPTN optineurin Inhibitor Q96CV9 10133 10p13 human S177-p 4762451 SSGSSEDsFVEIRMA protein stabilization; molecular association, regulation; intracellular localization cell cycle regulation; autophagy, induced; apoptosis, induced SPTLC3(INDUCES); RAB8A(DISRUPTS) 21617041; 22365832; 26376340; 27035970; 27247382; 34099552 10 30 1 induces mitophagy; mitophagy, formation of autophagosomes around depolarized mitochondria -TFAM TFAM DNA-binding; Transcription regulation Q00059 7019 10q21.1 human K197-ac 1876567510 KNLSDSEkELYIQHA HMG_box_2 transcription, induced 35278431 0 1 0 -CD274 PD-L1 Membrane protein, integral Q9NZQ7 29126 9p24.1 human S283-p 14735979 DTNSKKQsDTHLEET protein degradation; molecular association, regulation; ubiquitination carcinogenesis, inhibited CMTM4(DISRUPTS); ARIH1(INDUCES) 33879767; 33909988 2 7 0 -Myc Myc DNA-binding; Nucleolus; Oncoprotein; Transcription factor P01108 17869 15 D1|15 26.19 cM mouse S344-p 2750300 AKRAKLDsGRVLKQI Myc_N protein stabilization transcription, induced; cell growth, altered 18438430 2 1 0 enhances the oncogenic transforming activity of c-Myc -SMAD2 SMAD2 DNA-binding; Transcription factor Q15796 4087 18q21.1 human S260-p 450146 TLSPVNHsLDLQPVT molecular association, regulation; intracellular localization SMAD3(INDUCES) 11027280 1 0 0 -SLC9A1 NHE1 Membrane protein, integral; Membrane protein, multi-pass; Motility/polarity/chemotaxis; Transporter; Transporter, SLC family P19634 6548 1p36.11 human S796-p 460570 QRIQRCLsDPGPHPE molecular association, regulation CA2(NOT_REPORTED) 16475831 3 29 41 -EEF2K EEF2K EC 2.7.11.20; KINASE; Kinase, protein; Protein kinase, Ser/Thr (non-receptor); Protein kinase, atypical; Translation O00418 29904 16p12.2 human S72-p 3150896 KSERYSSsGSPANSF enzymatic activity, inhibited carcinogenesis, induced; cell growth, induced; translation, induced 35513296 0 12 1 -AURKA AurA EC 2.7.11.1; KINASE; Kinase, protein; Oncoprotein; Protein kinase, Other; Protein kinase, Ser/Thr (non-receptor) O14965 6790 20q13.2 human Y148-p 457653 KGKFGNVyLAREKQS Pkinase intracellular localization cell cycle regulation 27242098 2 5 7 centrosomal recruitment -APEX1 APE1 DNA repair, damage; DNA-binding; Deoxyribonuclease; EC 4.2.99.18; Endoplasmic reticulum; Hydrolase; Lyase; Nuclear receptor co-regulator; Nucleolus; Transcription, coactivator/corepressor P27695 328 14q11.2 human K27-ub 6423507 EPEAKKSkTAAKKND protein degradation; enzymatic activity, altered 19219073 1 0 0 -PDPK1 PDK1 EC 2.7.11.1; KINASE; Kinase, protein; Nuclear receptor co-regulator; Protein kinase, AGC; Protein kinase, Ser/Thr (non-receptor) O15530 5170 16p13.3 human S241-p 447693 SKQARANsFVGTAQY Pkinase molecular association, regulation; phosphorylation; enzymatic activity, induced carcinogenesis, induced; cell growth, induced; apoptosis, inhibited; autophagy, inhibited; signaling pathway regulation 14-3-3 theta(INDUCES); 14-3-3 eta(INDUCES) 10455013; 12177059; 14623982; 16780920; 21118801; 21308747; 22080480; 25384981; 27002159; 33755959; 35564180; 35884549; 36418288 63 95 264 induces Akt/mTOR signalling -PDGFRB PDGFRB EC 2.7.10.1; KINASE; Kinase, protein; Membrane protein, integral; Oncoprotein; Protein kinase, TK; Protein kinase, tyrosine (receptor) P09619 5159 5q32 human Y1021-p 447523 PNEGDNDyIIPLPDP activity, induced; molecular association, regulation; phosphorylation PLCG1(INDUCES) 11884598; 1396585; 7678051; 7876130; 9673410 21 0 0 Y1009 and Y1021 phosphorylation mediates PDGFBB and thrombin induced calcium signaling. ; Specificity of binding of SH2 domains can be tailored by change of residues in the +1 to +5 positions, flanking the phosphotyrosine. -PLD2 PLD2 EC 3.1.4.4; Lipid Metabolism - ether lipid; Lipid Metabolism - glycerophospholipid; Motility/polarity/chemotaxis; Phospholipase O14939 5338 17p13.2 human Y415-p 10036101 ALGINSGySKRALML molecular association, regulation; enzymatic activity, induced carcinogenesis, induced; cell motility, induced JAK2(INDUCES) 19715678; 20176813; 21414324; 23378025; 26124282 5 1 0 activates lipase activity and inhibits GEF activity -ESR1 ER-alpha DNA-binding; Nuclear receptor; Transcription factor P03372 2099 6q25.1-q25.2 human S102-p 449799 GGFPPLNsVSPSPLM Oest_recep activity, induced transcription, induced 16076840 3 1 0 -POLH POLH DNA repair, damage; EC 2.7.7.7; Transferase Q9Y253 5429 6p21.1 human K70-sm 1877365916 MWADDAKkLCPDLLL IMS intracellular localization; enzymatic activity, inhibited 32350109 1 1 0 -CD1D CD1D Apoptosis; Cell surface; Lipid-binding; Membrane protein, integral P15813 912 1q23.1 human S323-p 23091771 LLIVGFTsRFKRQTS protein degradation; intracellular localization 23710894 1 0 1 inhibits cell surface expression and antigen presentation -Npm1 NPM1 Nucleolus; Oncoprotein; RNA-binding; Translation Q61937 18148 11|11 A4 mouse K54-ac 15291352 VSLGAGAkDELHIVE Nucleoplasmin molecular association, regulation; intracellular localization MDM2(DISRUPTS) 33495326 1 5 1 Deacetylation of NPM1 at K27 and K54 leads to release of NPM from nucleoli and its association with HDM2. As a result HDM2-mediated proteasomal degradation of p53 is inhibited -SYK Syk EC 2.7.10.2; KINASE; Kinase, protein; Protein kinase, TK; Protein kinase, tyrosine (non-receptor) P43405 6850 9q22.2 human Y630-p 459326 ELRLRNYyYDVVN__ enzymatic activity, altered transcription, altered 9624129 3 2 5 -Plk4 PLK4 EC 2.7.11.21; KINASE; Kinase, protein; Nucleolus; Protein kinase, Other; Protein kinase, Ser/Thr (non-receptor) Q64702 20873 3|3 B mouse S303-p 12654008 ASSGTSLsGSLLDRR protein degradation; ubiquitination 20100909 2 1 0 -SF3B2 SF3B2 RNA processing; RNA splicing; RNA-binding; Spliceosome Q13435 10992 11q13.1 human S289-p 477883 SRQEEMNsQQEEEEM DNA repair, induced 29705135 1 18 0 accumulate CtIP at sites of DNA breaks -Agtr1 AT1 GPCR, family 1; Membrane protein, integral; Membrane protein, multi-pass; Receptor, GPCR P25095 24180 17p12 rat T336-p 467237 SLSTKMStLSYRPSD molecular association, regulation ARRB2(INDUCES) 29146594 3 0 0 BRET -AR AR DNA-binding; Nuclear receptor; Transcription factor P10275 367 Xq12 human S220-p 1875072200 EASGAPTsSKDNYLG Androgen_recep molecular association, regulation transcription, induced 14-3-3 zeta(INDUCES) DNA(INDUCES) 34697370 1 0 0 -RPRD1B RPRD1B Motility/polarity/chemotaxis Q9NQG5 58490 20q11.23 human S145-p 10404515 KATEEKKsLKRTFQQ molecular association, regulation cell cycle regulation; carcinogenesis, induced; cell growth, induced; transcription, induced; cytoskeletal reorganization AurB(INDUCES) 30518842 1 1 2 regulate the expression of cyclin B1 in gastric cancer -Tnni3 TNNI3 Actin-binding; Motility/polarity/chemotaxis; Motor P48787 21954 7 A1|7 2.61 cM mouse S45-p 450691 KKSKISAsRKLQLKT activity, induced; activity, inhibited; protein conformation cell motility, altered; cytoskeletal reorganization 12003851; 12181153; 12923217; 14726296; 17010989; 17872964; 19426736; 20083117 22 3 0 slows rate of contraction and relaxation -MET Met EC 2.7.10.1; KINASE; Kinase, protein; Membrane protein, integral; Oncoprotein; Protein kinase, TK; Protein kinase, tyrosine (receptor) P08581 4233 7q31.2 human Y1356-p 448473 YVHVNATyVNVKCVA activity, induced; molecular association, regulation; enzymatic activity, induced carcinogenesis, induced; cell motility, induced; cell growth, induced; cell motility, altered; signaling pathway regulation; cell growth, altered PIK3C2A(INDUCES); GRB2(INDUCES); Src(INDUCES); PLCG1(INDUCES); Ron(INDUCES); SOS1(INDUCES); GAB1(INDUCES); Met(INDUCES); SHC1(INDUCES); FAK(INDUCES); PIK3R1(INDUCES) 10490849; 10506185; 10871856; 12766170; 16782899; 21777671; 7513258; 7687741; 7731718; 7838524; 7961992; 8547236; 8906793; 9242692; 9391119; 9444958 23 4 122 binding of Gab1 is dependent on Grb2; Double mutant Y1349F/Y1356F inhibits both metastasis and transformation. N1358H is also critical for malignant transformation as it affects Grb2 binding and activation of the Ras pathway (mutantGRB-). H1352N which makes an high affinity GRB2 was highly transforming, but not metastatic (mutant 2X Grb2). Expression of the recombinant oncogene TPR-SEA, was comaparable to 2X GRB2 mutant phenotype. A GRB2/2X GRB2 mutant was rescued by complementation in trans and resumed the ability to invade an in vitro reconstituted basement membrane. ; promotes cell transformation in Tpr-Met expressing cells -NDEL1 NDEL1 Microtubule-binding; Protease Q9GZM8 81565 17p13.1 human S231-p 474507 GTENTFPsPKAIPNG NUDE_C molecular association, regulation; intracellular localization PAFAH1B1(INDUCES); DYNC1I1(INDUCES) 12556484; 37086789 5 18 0 -Eif4ebp1 4E-BP1 Translation; Translation initiation Q60876 13685 8 A2|8 15.95 cM mouse T36-p 447497 PPGDYSTtPGGTLFS eIF_4EBP molecular association, regulation carcinogenesis, induced; apoptosis, inhibited; transcription, induced; translation, induced; signaling pathway regulation EIF4E(DISRUPTS); EIF4E(INDUCES) 11875068; 17510058; 18851840; 33567340; 34704268; 36012713; 37264081 159 44 88 -Arrb1 ARRB1 Adaptor/scaffold P29066 25387 1q32 rat S412-p 447493 EEDDGTGsPHLNNR_ intracellular localization 9388255 8 46 1 Cytoplasmic beta-arrestin 1 is constitutively phosphorylated. It is recruited to the plasma membrane by agonist binding to receptor where is rapidly dephosphorylated. Dephosphorylation is required for clathrin binding and receptor endocytosis. -HSPA5 GRP78 Chaperone; Heat shock protein; KINASE P11021 3309 9q33.3 human K138-ac 13362606 DIGGGQTkTFAPEEI HSP70 molecular association, regulation; phosphorylation apoptosis, induced; signaling pathway regulation PERK(DISRUPTS) 20371724 1 1 0 induces phosphorylation of elf2a and activation of eIf2a-ATF4-CHOP pathway -Myo1c MYO1C iso3 Actin-binding; Contractile; Lipid-binding; Motility/polarity/chemotaxis; Motor; Nucleolus Q9WTI7-3 17913 11 B5|11 45.92 cM mouse S1020-p 34404301 DGIIDFTsGSELLIT Myosin_TH1 protein stabilization; molecular association, regulation cell cycle regulation; transcription, induced DNA(INDUCES) 24901984 1 1 0 -HSPD1 HSP60 Chaperone; Mitochondrial P10809 3329 2q33.1 human S70-p 468008 IIEQSWGsPKVTKDG Cpn60_TCP1 protein conformation 34557266 1 66 0 regulates folding of ALDH2 and ACADS -ITK ITK EC 2.7.10.2; KINASE; Kinase, protein; Protein kinase, TK; Protein kinase, tyrosine (non-receptor) Q08881 3702 5q33.3 human Y180-p 449834 ETVVIALyDYQTNDP SH3_1 phosphorylation; enzymatic activity, induced signaling pathway regulation 31196981 3 0 80 autophosphorylation at Y180 -Psma1 PSMA1 EC 3.4.25.1; Protease; Proteasome complex Q9R1P4 26440 7 F1|7 59.32 cM mouse K115-ac 31910304 LVSLIGSkTQIPTQR Proteasome protein degradation 24037710 0 1 0 -OGG1 OGG1 DNA repair, damage; Deoxyribonuclease; EC 4.2.99.18; Lyase O15527 4968 3p25.3 human K338-ac 40320204 EPPAKRRkGSKGPEG DNA repair, induced; apoptosis, inhibited 25660075 1 0 0 -BCL10 Bcl-10 Apoptosis; Transcription, coactivator/corepressor; Tumor suppressor O95999 8915 1p22.3 human K17-ub 59171801 EEDLTEVkKDALENL molecular association, regulation carcinogenesis, induced; transcription, induced; signaling pathway regulation IKKG(INDUCES) 27777308 1 0 0 TCR-mediated NF-?B activation -Crtc2 TORC2 Transcription, coactivator/corepressor Q3U182 74343 3|3 F1 mouse S136-p 454632 PYSPAYLsPPPESGW molecular association, regulation; intracellular localization transcription, induced SEC31A(DISRUPTS) 33434948 3 16 43 binding to SEC31A inhibits SEC31A binding to SEC23A -Cyp2e1 CYP2E1 EC 1.14.13.n7; Endoplasmic reticulum; Lipid Metabolism - arachidonic acid; Lipid Metabolism - linoleic acid; Mitochondrial; Oxidoreductase; Xenobiotic Metabolism - drug metabolism - cytochrome P450; Xenobiotic Metabolism - metabolism by cytochrome P450 Q05421 13106 7 F4|7 85.94 cM mouse R379-me 1878196104 ATRDTVFrGYVIPKG protein degradation 31077594 1 1 0 me-CYP2E1 is reduced in Mat1a KO liver mitochondria; down-regulation of CYP2E1 protein level requires R379 methylation -YWHAB 14-3-3 beta iso2 Adaptor/scaffold P31946-2 7529 20q13.12 human K49-ac 474927 NLLSVAYkNVVGARR 14-3-3 intracellular localization; activity, inhibited cell differentiation, induced 34379822 2 5 15 osteogenesis -MAPRE1 EB1 Cytoskeletal; Motility/polarity/chemotaxis Q15691 22919 20q11.21 human Y247-p 59026901 QRIVDILyATDEGFV EB1 molecular association, regulation; intracellular localization; protein conformation; phosphorylation cell cycle regulation; cell motility, induced; transcription, induced; cytoskeletal reorganization; cell adhesion, altered; signaling pathway regulation KIF2C(DISRUPTS); APC(DISRUPTS) 27698945; 31505167; 32469452 3 1 0 Regulates astral microtubule stability and spindle misorientation; regulates TCR signaling; increases levels of CD25 and CD69; phosphorylation of EB1 at Y247 occurs primarily at the centrosome, increases the rate of microtuble catastrophe; induces phosphorylation of ZAP-70, LAT and ERK; increase NFAT1 nuclear translocation -IRF3 IRF3 DNA-binding; Transcription factor Q14653 3661 19q13.33 human K87-sm 25174503 FRSALNRkEGLRLAE IRF protein stabilization; ubiquitination 22028379 1 0 0 deSUMOylation promotes ubiquitination and degradation at the same residues -DDX5 DDX5 EC 3.6.4.13; Helicase; Nuclear receptor co-regulator; Nucleolus; RNA splicing; RNA-binding; Spliceosome P17844 1655 17q23.3 human K45-ac 15211500 GEKLVKKkWNLDELP protein stabilization; molecular association, regulation carcinogenesis, induced; transcription, induced HDAC1(INDUCES); HDAC2(INDUCES) 20663877 1 1 0 -Shtn1 SHOT1 Unknown function Q8K2Q9 71653 19|19 D2-D3 mouse S249-p 485709 QNKLKRQsHLLLQSS molecular association, regulation neural plasticity; cell adhesion, induced; cytoskeletal reorganization CDH2(INDUCES); Cortactin(INDUCES); NCAM-L1(INDUCES) 34010643 4 19 4 -Sod2 SOD2 EC 1.15.1.1; Mitochondrial; Oxidoreductase P09671 20656 17 A1|17 8.75 cM mouse R197-m2 1872904404 YLQYKNVrPDYLKAI Sod_Fe_C cell cycle regulation 22710435 1 1 0 quiescent fibroblasts are dimethylated at K122, and R197 and are also dimethylated in proliferating cells -Ccnd1 CCND1 Activator; Cell cycle regulation; Nuclear receptor co-regulator; Oncoprotein P25322 12443 7 F5|7 88.92 cM mouse T288-p 451435 AGLACTPtDVRDVDI protein degradation cell cycle regulation 15075324; 19542220 5 0 0 -Pdha1 PDHA1 Amino Acid Metabolism - valine, leucine and isoleucine biosynthesis; Carbohydrate Metabolism - butanoate; Carbohydrate Metabolism - citrate (TCA) cycle; Carbohydrate Metabolism - glycolysis and gluconeogenesis; Carbohydrate Metabolism - pyruvate; EC 1.2.4.1; Mitochondrial; Oxidoreductase P35486 18597 X F4|X 73.95 cM mouse K385-ac 1204112 RGANQWIkFKSVS__ enzymatic activity, inhibited 34518519 1 3 1 metabolic reprogramming associated with renal ?brosis -Vrk1 VRK1 EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, CK1; Protein kinase, Ser/Thr (non-receptor) Q80X41 22367 12|12 E-F1 mouse S355-p 483969 SVKTRPAsKKRKKEA enzymatic activity, inhibited cell cycle regulation; apoptosis, altered 21346188 3 0 0 -Wnk1 WNK1 EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, Other; Protein kinase, Ser/Thr (non-receptor) Q9JIH7 116477 4q42 rat S382-p 454105 KRASFAKsVIGTPEF Pkinase enzymatic activity, induced 12374799 9 10 3 -PPP1R2 PPP1R2 Inhibitor; Motility/polarity/chemotaxis; Protein phosphatase, regulatory subunit P41236 5504 3q29 human S121-p 449052 YRIQEQEsSGEEDSD IPP-2 intracellular localization 9405437 3 72 29 Phosphorylation is required for nuclear localization during S phase. -TET2 TET2 EC 1.14.11.n2; Oxidoreductase; Tumor suppressor Q6N021 54790 4q24 human Y1902-p 1870773107 TRISLVFyQHKSMNE Tet_JBP protein degradation; ubiquitination cell cycle regulation; carcinogenesis, induced; cell growth, induced; apoptosis, inhibited; transcription, inhibited 33097695 1 1 0 -Themis THEMIS Cell development/differentiation Q8BGW0 210757 10|10 A4 mouse Y543-p 27806310 EITEEQYyMMRRYES cell differentiation, induced 23460737 1 1 0 thymocyte development -Sh2d1b SH2D1B Adaptor/scaffold O35324 26904 1|1 H3 mouse Y127-p 4140135 YENTDEEyVDVLP__ molecular association, regulation exocytosis, induced; cytoskeletal reorganization PLCG1(INDUCES) 24687958 2 0 8 activating function of CD244 required the C-terminal tyrosine Y127, SH2D18 promoted MTOC and granule polarization and exocytosis -IL7R IL7R Membrane protein, integral; Receptor, cytokine P16871 3575 5p13.2 human Y449-p 451291 GSNQEEAyVTMSSFY molecular association, regulation PIK3R1(INDUCES) 7522165 7 0 0 -TARBP2 TRBP Motility/polarity/chemotaxis; RNA processing; RNA-binding; Translation Q15633 6895 12q13.13 human K52-sm 52477001 TPVYDLLkAEGQAHQ dsrm protein stabilization; molecular association, regulation; ubiquitination carcinogenesis, inhibited; cell motility, inhibited; RNA stability, inhibited AGO2(INDUCES) RNA(INDUCES) 26582366 1 0 0 inhibits ubiquitination -KIF2A KIF2A Microtubule-binding; Motor O00139 3796 5q12.1 human S100-p 23119257 KNRRTVAsIKNDPPS activity, induced; molecular association, regulation; intracellular localization cell cycle regulation DVL1(INDUCES); DVL3(INDUCES); DVL2(INDUCES) 34417301 1 10 2 -H1-2 H1C DNA-binding P16403 3006 6p22.2 human T146-p 9765189 KKAAGGAtPKKSAKK molecular association, regulation cell cycle regulation; carcinogenesis, inhibited; cell growth, inhibited; apoptosis, induced; cell motility, inhibited; transcription, induced; transcription, altered p53(DISRUPTS) 22249259; 24601643; 28392790; 31032946 4 17 8 -Camk2a CAMK2A EC 2.7.11.17; KINASE; Kinase, protein; Protein kinase, CAMK; Protein kinase, Ser/Thr (non-receptor) P11275 25400 18q12.1 rat T305-p 448802 KLKGAILtTMLATRN molecular association, regulation; enzymatic activity, inhibited cytoskeletal reorganization Calmodulin(DISRUPTS) 1324926; 20660727; 2162839 24 5 1 regulate synaptic strength -WT1 WT1 iso7 C2H2-type zinc finger protein; DNA-binding; Nucleolus; Transcription factor; Tumor suppressor P19544-7 7490 11p13 human S67-p 56653434 GRRSRGAsGSEPQQM protein stabilization carcinogenesis, induced; cell growth, induced 29040381 2 3 0 -HNRNPD hnRNP D0 RNA splicing; RNA-binding Q14103 3184 4q21.22 human S83-p 449336 DEGHSNSsPRHSEAA phosphorylation transcription, inhibited; RNA stability, altered RNA(INDUCES) 11903055; 12819194; 36041631 4 74 16 -Ripk3 RIPK3 EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, Ser/Thr (non-receptor); Protein kinase, TKL Q9QZL0 56532 14|14 C3 mouse S369-p 27928505 ERQAQDTsVGPATPA protein stabilization; molecular association, regulation apoptosis, induced FADD(INDUCES) 33870135 2 2 0 prevents ripoptosome-mediated cleavage of RIPK3 -Snai1 Snail1 C2H2-type zinc finger protein; Transcription factor Q02085 20613 2 H3|2 87.33 cM mouse S165-p 1876128600 YCNKEYLsLGALKMH zf-C2H2_6 protein stabilization; molecular association, regulation; ubiquitination carcinogenesis, induced; cell motility, induced; transcription, altered BTRC(DISRUPTS) 35066576 1 1 0 inhibits ubiquitination -MARCKS MARCKS Actin-binding; Motility/polarity/chemotaxis P29966 4082 6q21 human S167-p 466360 FKKSFKLsGFSFKKN MARCKS exocytosis, inhibited 21762971 7 44 11 induce MUC5AC secretion by cold -ESR2 ER-beta DNA-binding; Nuclear receptor Q92731 2100 14q23.2-q23.3 human Y488-p 450057 CKNVVPVyDLLLEML activity, induced; molecular association, regulation; protein conformation SRC-2(INDUCES); PGC-1 alpha(INDUCES); NR0B1(INDUCES); RIP140(INDUCES); SRC-1(INDUCES) 25386784 3 1 0 based on in-vitro binding affinities of phosphorylated ER-beta to corresponding coregulator peptides -Stk4 MST1 Autophagy; EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, STE; Protein kinase, Ser/Thr (non-receptor) Q9JI11 58231 2|2 H3 mouse S327-p 447924 SEEDEMDsGTMVRAA enzymatic activity, induced cell adhesion, altered 12223493 2 1 1 -ARAF ARAF EC 2.7.11.1; KINASE; Kinase, protein; Oncoprotein; Protein kinase, Ser/Thr (non-receptor); Protein kinase, TKL P10398 369 Xp11.3 human S432-p 3306310 IIHRDLKsNNIFLHE PK_Tyr_Ser-Thr enzymatic activity, induced 18662992 1 1 0 -CDH1 CDH1 Cell adhesion; Membrane protein, integral; Motility/polarity/chemotaxis; UBIQUITIN LIGASE; Ubiquitin ligase P12830 999 16q22.1 human S844-p 478354 GSGSEAAsLSSLNSS CADH_Y-type_LIR protein stabilization; molecular association, regulation; intracellular localization carcinogenesis, altered; cell motility, inhibited; cell adhesion, altered CTNNB1(DISRUPTS) 17353278; 35115926 4 0 0 -Tcap Telethonin Motility/polarity/chemotaxis O70548 21393 11|11 D mouse S161-p 3893741 RTLSRSMsQEAQRG_ Telethonin protein stabilization; ubiquitination 34566695 3 8 3 inhibits ubiquitination -KDM3A JMJD1A DEMETHYLASE; Demethylase; EC 1.14.11.-; Nuclear receptor co-regulator; Oxidoreductase Q9Y4C1 55818 2p11.2 human K421-ac 1877323800 PKECLPTkASSKAEL protein stabilization; intracellular localization carcinogenesis, induced; cell growth, induced CHIP(DISRUPTS); BRD4(INDUCES) 32522824 1 1 0 K421 acetylation promotes JMJD1A recruitment to AR via BRD4 and prostate cancer cell growth -CDKN1B p27Kip1 Cell cycle regulation; Inhibitor; Oncoprotein; Protein kinase, regulatory subunit P46527 1027 12p13.1 human S140-p 481797 PKTDPSDsQTGLAEQ protein stabilization cell cycle regulation; cell growth, inhibited 27611996; 31959038 3 4 1 -Cish CISH O70512 83681 8q32 rat K58-ub 37044804 VQSENEPkVLDPEGD protein degradation 25448846 1 0 0 -Khdc3 KHDC3L Cell cycle regulation Q9CWU5 66991 9|9 D mouse S349-p 41159605 REAATQLsPVEATDT intracellular localization DNA repair, induced 25936915 1 0 0 required for KHD3CL function in DNA repair and nuclear localization -DDAH2 DDAH2 Apoptosis; EC 3.5.3.18; Hydrolase O95865 23564 6p21.33 human T203-p 1872776102 VRAMAVLtDHPYASL intracellular localization; phosphorylation; enzymatic activity, induced signaling pathway regulation 33850055 1 1 0 regulates RLR signaling, regulates DRP1 anf IRF3 phosphorylation -KDM4B JMJD2B DEMETHYLASE; Demethylase; EC 1.14.11.-; Oxidoreductase O94953 23030 19p13.3 human T1065-p 479896 AKRPRVGtPLATEDS protein stabilization; ubiquitination 28945223 1 11 92 -IL24 IL24 Motility/polarity/chemotaxis; Secreted; Secreted, signal peptide Q13007 11009 1q32.1 human T133-p 41122602 NRTVEVRtLKSFSTL activity, induced; intracellular localization cell cycle regulation; carcinogenesis, inhibited; cell growth, inhibited; cell motility, inhibited; signaling pathway regulation 26009991 1 0 0 IL24 maturation and secretion; activates Caspase-9, PARP, and JNK; inhibits the AKT signaling pathway -PIK3C3 PIK3C3 Autophagy; Carbohydrate Metabolism - inositol phosphate; EC 2.7.1.137; Kinase, lipid; Motility/polarity/chemotaxis Q8NEB9 5289 18q12.3 human K781-ac 280006401 PPPMKLNkEMVEGMG PI3_PI4_kinase enzymatic activity, inhibited autophagy, inhibited 28844862 1 1 0 nutrient starvation-induced autophagy -LRRK1 LRRK1 EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, Ser/Thr (non-receptor); Protein kinase, TKL Q38SD2 79705 15q26.3 human S1074-p 1879806802 GNQRNRCsTFRVKRN phosphorylation; enzymatic activity, induced 36040231 1 1 0 induces Rab7 phosphorylation -Nr1h3 LXR-alpha DNA-binding; Motility/polarity/chemotaxis; Nuclear receptor Q9Z0Y9 22259 2 E1|2 50.52 cM mouse S195-p 479432 TSVSPRVsSPPQVLP molecular association, regulation; activity, inhibited cell growth, induced; apoptosis, induced; transcription, altered; transcription, inhibited; signaling pathway regulation SRC-1(DISRUPTS); N-CoR1(INDUCES); RXRA(DISRUPTS) 17296605; 33772096 2 0 0 regulates inflammatory signaling; DNA Binding Activity of LXR/ RXR heterodimer was decreased. -PCNA PCNA Cell cycle regulation; DNA replication P12004 5111 20p12.3 human Y211-p 471414 QLTFALRyLNFFTKA PCNA_C molecular association, regulation; protein stabilization; ubiquitination carcinogenesis, induced; cell growth, induced; DNA repair, inhibited CUL4A(DISRUPTS) 17115032; 22692198; 25825764; 28102297 7 2 2 -ID1 ID1 DNA-binding; Transcription, coactivator/corepressor P41134 3397 20q11.21 human S36-p 15411040 GEVVRCLsEQSVAIS molecular association, regulation; ubiquitination TRAF6(INDUCES) 29079782 1 2 4 -PDE4D PDE4D iso6 EC 3.1.4.53; Nucleotide Metabolism - purine; Phosphodiesterase Q08499-6 5144 5q11.2-q12.1 human K140-ub 7388020 SDYDLSPkSMSRNSS molecular association, regulation; ubiquitination RACK1(DISRUPTS); ARRB1(INDUCES) 19372219 1 0 0 primes ubiquitination at other sites -EHMT2 EHMT2 Amino Acid Metabolism - lysine degradation; EC 2.1.1.43; METHYLTRANSFERASE; Methyltransferase; Methyltransferase, protein lysine Q96KQ7 10919 6p21.33 human S569-p 456315 APAPPPLsQDVPGRA intracellular localization DNA repair, induced 29192276 1 7 22 recruitment to DNA breaks -PACSIN2 PACSIN2 Adaptor/scaffold; Motility/polarity/chemotaxis Q9UNF0 11252 22q13.2 human S375-p 4786399 DDTGSTVsEKDDTKA molecular association, regulation; receptor internalization, altered neural plasticity PICK1(DISRUPTS) 23918399 1 9 0 regulates AMPAR trafficking -COP1 COP1 EC 6.3.2.-; EC 6.3.2.19; Ligase; UBIQUITIN LIGASE; Ubiquitin conjugating system; Ubiquitin ligase Q8NHY2 64326 1q25.1-q25.2 human S387-p 467307 SDDSRTAsQLDEFQE protein degradation; molecular association, regulation; ubiquitination; intracellular localization 14-3-3 sigma(INDUCES); p27Kip1(DISRUPTS); p53(DISRUPTS) 16931761; 20843328; 25957415 3 0 1 -Becn1 beclin 1 Adaptor/scaffold; Autophagy; Membrane protein, peripheral Q91XJ1 rat T117-p 6406000 LSRRLKVtGDLFDIM BH3 autophagy, induced 35263212 4 0 0 -FSCN1 fascin Actin-binding; Cytoskeletal; Motility/polarity/chemotaxis Q16658 6624 7p22.1 human S39-p 450888 KVNASASsLKKKQIW Fascin molecular association, regulation; intracellular localization; protein conformation cell growth, inhibited; cell motility, inhibited; cytoskeletal reorganization FMNL2(DISRUPTS); ACTA1(DISRUPTS); ACTA1(INDUCES) 20137952; 27554857; 28251354; 30664308; 32294157; 8999969 13 12 0 -ARAF ARAF EC 2.7.11.1; KINASE; Kinase, protein; Oncoprotein; Protein kinase, Ser/Thr (non-receptor); Protein kinase, TKL P10398 369 Xp11.3 human S264-p 3306300 SPSPASVsSGRKSPH enzymatic activity, induced 18662992 1 1 0 -INSIG2 INSIG2 Endoplasmic reticulum; Membrane protein, integral; Membrane protein, multi-pass; Transcription, coactivator/corepressor Q9Y5U4 51141 2q14.1-q14.2 human K102-ub 486342 LGEPHKFkREWSSVM INSIG protein degradation 16549805 1 0 0 INSIG1 is degraded more rapidly than INSIG2 which controlled by serine residues flanking the ubiquitination sites in both proteins. -PARP1 PARP1 DNA repair, damage; EC 2.4.2.30; Nuclear envelope; Nuclear receptor co-regulator; Nucleolus; Transferase P09874 142 1q42.12 human S177-p 18013484 LGFRPEYsASQLKGF zf-PARP molecular association, regulation cell adhesion, induced; transcription, altered; signaling pathway regulation DNA(DISRUPTS) 23382195 2 4 0 induces transcription of itself and inhibits transcription of VCAM-1, MCP-1, and MCP-3, regulates AMPK-PARP-1-Bcl-6 pathway -CDC25A CDC25A EC 3.1.3.48; Motility/polarity/chemotaxis; PHOSPHATASE; Protein phosphatase, dual-specificity P30304 993 3p21.31 human S124-p 449127 PALKRSHsDSLDHDI M-inducer_phosp protein degradation 11298456; 12676583 7 1 0 -PROM1 CD133 iso2 Cell surface; Membrane protein, integral; Membrane protein, multi-pass O43490-2 8842 4p15.32 human Y819-p 462569 RMDSEDVyDDVETIP molecular association, regulation ARL13B(INDUCES) 32201384 4 2 20 regulates ciliary length -TACSTD2 TACSTD2 Membrane protein, integral; Receptor, misc. P09758 4070 1p32.1 human S322-p 470219 GELRKEPsL______ protein degradation; molecular association, regulation; intracellular localization; phosphorylation carcinogenesis, induced; cell growth, induced; cell motility, induced; cytoskeletal reorganization; transcription, altered; signaling pathway regulation Claudin-7(DISRUPTS) 31177095; 35132180; 37380081 3 8 0 induces STAT3 phosphorylation, regulates ?-catenin signaling -Ppargc1b PGC-1 beta Nuclear receptor co-regulator; Transcription, coactivator/corepressor Q8VHJ7 170826 18|18 E1 mouse K218-ac 7761208 RPCTELHkHLTSVLP intracellular localization transcription, inhibited 19491097 1 1 0 -Cd83 CD83 Membrane protein, integral O88324 12522 13 A4|13 21.6 cM mouse K183-ub 9381802 LPVTSPSkHLGPVTL protein degradation 19542455 1 3 0 -POLB POLB DNA repair, damage; DNA replication; EC 2.7.7.7; Lyase; Transferase P06746 5423 8p11.21 human S44-p 41521700 NAYRKAAsVIAKYPH HHH_8 enzymatic activity, inhibited; protein conformation 29223917; 30138833; 37240334 4 1 0 -KDM1A LSD1 DEMETHYLASE; Demethylase; EC 1.-.-.-; Nuclear receptor co-regulator; Oxidoreductase; Transcription factor O60341 23028 1p36.12 human S683-p 57786402 NLFGHVGsTTASRGE Amino_oxidase protein stabilization; molecular association, regulation; intracellular localization; phosphorylation cell growth, induced USP22(INDUCES) 27501329 1 0 0 S687 phosphorylation by CK1 primes for GSK3B phosphorylation S683 deubiquitylation, maintaining the stemness of GSCs -TK1 TK EC 2.7.1.21; KINASE; Kinase, other; Nucleotide Metabolism - pyrimidine; Xenobiotic Metabolism - drug metabolism - other enzymes P04183 7083 17q25.3 human S231-p 483564 PQQILQCsPAN____ enzymatic activity, induced 25003822 1 21 5 TK phosphorylation-modulated [18F]FLT cellular retention -JUN Jun Oncoprotein; Transcription factor P05412 3725 1p32.1 human Y170-p 447687 LHSEPPVyANLSNFN Jun molecular association, regulation Abl iso2(INDUCES) 10637231 2 1 0 -AKT1 Akt1 EC 2.7.11.1; KINASE; Kinase, protein; Oncoprotein; Protein kinase, AGC; Protein kinase, Ser/Thr (non-receptor) P31749 207 14q32.33 human R391-m2 1883833702 LKKDPKQrLGGGSED intracellular localization; enzymatic activity, induced carcinogenesis, induced; cell growth, induced 34103528 1 1 0 AKT1 membrane translocation and subsequent activation by PDK1 and mTORC2; PI3K signaling enhances AKT1-R391 dimethylation -STAT1 STAT1 DNA-binding; Transcription factor P42224 6772 2q32.2 human S708-p 7723201 YIKTELIsVSEVHPS transcription, induced 24882218 2 2 0 -MC4R MC4R GPCR, family 1; Membrane protein, integral; Membrane protein, multi-pass; Receptor, GPCR P32245 4160 18q21.32 human S329-p 449102 LGGLCDLsSRY____ receptor recycling, inhibited; intracellular localization; receptor internalization, altered; activity, inhibited 12639913; 22544740 2 0 0 retains MC4R in the endosomal compartment -Ptpra PTPRA EC 3.1.3.48; Membrane protein, integral; Motility/polarity/chemotaxis; PHOSPHATASE; Receptor protein phosphatase, tyrosine P18052 19262 2 F1|2 63.23 cM mouse S204-p 447612 PLLARSPsTNRKYPP molecular association, regulation; enzymatic activity, induced cytoskeletal reorganization Src iso1(DISRUPTS) 18809727; 20385765 6 3 1 neurite outgrowth -Ttll4 TTLL4 EC 6.-.-.-; Ligase Q80UG8 67534 1|1 C4 mouse Y815-p 1873647202 VNKKNTEyQANADET TTL enzymatic activity, induced 34084286 1 1 0 -POLB POLB DNA repair, damage; DNA replication; EC 2.7.7.7; Lyase; Transferase P06746 5423 8p11.21 human R152-m1 2363901 DFEKRIPrEEMLQMQ DNA_pol_B_palm DNA repair, induced 16600869 1 0 0 -Tsc2 TSC2 Cell cycle regulation; GAP; GAP, misc.; Nuclear receptor co-regulator; Tumor suppressor P49816 24855 10q12 rat S1381-p 450215 VDLSFQPsQPLSKSS activity, inhibited; phosphorylation translation, altered; apoptosis, inhibited 16959574 2 0 1 inhibits mTOR signaling. required for Wnt-3a to stimulation phosphorylation of S6K and 4EBP1 and increase protein levels of cyclin D1 and VEGF (cyclin D1 through translation not transcription). -Mcu MCU Membrane protein, integral; Membrane protein, multi-pass; Mitochondrial Q3UMR5 215999 10|10 B4 mouse S91-p 27259017 VISVRLPsRRERCQF apoptosis, induced 23051746 4 0 0 increase CCDC109A current and myocardial cell death -HNRNPK hnRNP K RNA splicing; RNA-binding; Spliceosome P61978 3190 9q21.32 human Y380-p 456004 YAGGRGSyGDLGGPI translation, altered 12052863 2 23 20 based on Y72/225/230/234/236/380A mutant -TP53 p53 Activator; DNA-binding; Motility/polarity/chemotaxis; Nuclear receptor co-regulator; Transcription factor; Tumor suppressor P04637 7157 17p13.1 human T304-p 50310600 HELPPGStKRALPNN intracellular localization apoptosis, induced; transcription, induced; translation, induced 26384650; 27914807 2 0 0 nuclear accumulation, p21 transcription, cleaved PARP and cytotoxicity ; T304/377D p53 induces TNF-alpha mRNA, secretion of pro-in?ammatory cytokine TNF-alpha, and apoptosis -Dppa2 DPPA2 Cancer Testis Antigen (CTA) Q9CWH0 73703 16|16 B5 mouse K108-sm 1877735401 NLSTDGKkVEVYLRL sumoylation transcription, inhibited 31226106 1 1 0 impairs early embryo development -PSMD1 PSMD1 Protease; Proteasome complex Q99460 5707 2q37.1 human Y950-p 23135657 EPPEPFEyIDD____ molecular association, regulation ADRM1(INDUCES) 31064842 1 0 1 -CENPA CENPA DNA-binding P49450 1058 2p23.3 human K49-ub 1876695602 RRRQGWLkEIRKLQK Histone protein degradation; intracellular localization cell cycle regulation 34758320 1 1 0 Ser68 facilitates degradation -SKIL SKIL Cell development/differentiation; Transcription, coactivator/corepressor P12757 6498 3q26.2 human K50-sm 3144802 INKVPTVkKEHLDDY cell differentiation, inhibited; carcinogenesis, inhibited; cell growth, inhibited; transcription, inhibited 16966324; 17202138; 28493978 3 0 0 -CTNND1 CTNND1 Actin-binding; Adaptor/scaffold; Cell adhesion; G protein regulator, misc.; Motility/polarity/chemotaxis O60716 1500 11q12.1 human T308-p 3651652 DYGTARRtGTPSDPR molecular association, regulation SMURF1(INDUCES) 32010791 1 3 4 -Akt1 Akt1 EC 2.7.11.1; KINASE; Kinase, protein; Oncoprotein; Protein kinase, AGC; Protein kinase, Ser/Thr (non-receptor) P31750 11651 12 F1|12 61.2 cM mouse Y176-p 14515900 EKATGRYyAMKILKK Pkinase intracellular localization; enzymatic activity, induced cell cycle regulation; transcription, altered 20333297 3 1 0 membrane localization -Foxp3 FOXP3 C2H2-type zinc finger protein; Cell cycle regulation; DNA-binding; Transcription factor Q99JB6 20371 X A1.1|X 3.41 cM mouse K262-ub 1875395602 MQAHLAGkMALAKAP intracellular localization 30886105 3 0 0 K262 is important for Treg function and stability -IRF3 IRF3 DNA-binding; Transcription factor Q14653 3661 19q13.33 human K193-ub 21177062 GPSENPLkRLLVPGE intracellular localization apoptosis, induced 27178468 1 4 0 -EMD emerin Cytoskeletal; Membrane protein, integral P50402 2010 Xq28 human Y34-p 10897602 VGSTRRLyEKKIFEY LEM molecular association, regulation BAF(INDUCES) 19789182 1 1 0 -CBL CBL Adaptor/scaffold; EC 6.3.2.-; EC 6.3.2.19; Ligase; Motility/polarity/chemotaxis; Oncoprotein; UBIQUITIN LIGASE; Ubiquitin conjugating system; Ubiquitin ligase P22681 867 11q23.3 human Y674-p 448874 SSSANAIySLAARPL cell motility, altered 15922744 2 34 715 Cbl mutant Y674/700/731/735/774F was used in this experiment -Rb1 Rb Nuclear receptor co-regulator; Oncoprotein; Transcription, coactivator/corepressor; Tumor suppressor P13405 19645 14 38.73 cM|14 D3 mouse S224-p 450020 VDYFIKFsPPALLRE molecular association, regulation E2F1(DISRUPTS) 10207050 3 0 0 -Src Src EC 2.7.10.2; KINASE; Kinase, protein; Oncoprotein; Protein kinase, TK; Protein kinase, tyrosine (non-receptor) Q9WUD9 83805 3q42 rat S17-p 448231 DASQRRRsLEPAENV enzymatic activity, induced cell growth, altered 15546918 10 46 12 -NR5A1 STF-1 Nuclear receptor; Transcription, coactivator/corepressor Q13285 2516 9q33.3 human K38-ac 458973 ESCKGFFkRTVQNNK zf-C4 protein stabilization; intracellular localization transcription, induced 11479297 1 1 0 localization to the cytoplasm -MAP4 MAP4 Cytoskeletal; Motility/polarity/chemotaxis P27816 4134 3p21.31 human K1034-ac 3284649 NKKVDISkVSSKCGS Tubulin-binding cytoskeletal reorganization 28002468 1 2 2 -Nfe2l2 NRF2 DNA-binding; Transcription factor Q60795 18024 2 C3|2 44.75 cM mouse S355-p 18258504 PEHSVESsIYGDPPP protein degradation; molecular association, regulation BTRC(INDUCES) 21245377 1 0 0 -NGEF ephexin-1 GEF; GEF, Rac/Rho Q5I1Y9 424744 chicken Y17-p 455579 IEHIGLLyQEYRDKS activity, induced cell motility, altered; cytoskeletal reorganization 15848799 4 0 2 -XRCC1 XRCC1 DNA repair, damage P18887 7515 19q13.31 human S578-p 40274402 GELEDYMsDRVQFVI BRCT_2 molecular association, regulation PARP1(DISRUPTS) 25477519 1 1 0 -RCAN1 RCAN1 Inhibitor P53805 1827 21q22.12 human T247-p 21511701 QTRRPEYtPIHLS__ protein stabilization transcription, inhibited PPP3CA(DISRUPTS) 21965663 2 0 0 inhibits calcineurin phosphatase activity and NFAT-dependent transcription -CD84 CD84 Cell surface; Immunoglobulin superfamily; Membrane protein, integral; Motility/polarity/chemotaxis Q9UIB8 8832 1q23.3 human Y296-p 454840 QPAESRIyDEILQSK molecular association, regulation SH2D1B(NOT_REPORTED); Arg(NOT_REPORTED) 23322602 0 14 200 -TAF5 TAF5 Q15542 6877 10q24.33 human K14-sm 12004437 EQTEVAVkLEPEGPP molecular association, regulation DNA(DISRUPTS) 15637059 1 0 0 -RPS3 RPS3 Apoptosis; EC 4.2.99.18; RNA-binding; Ribosomal; Translation P23396 6188 11q13.4 human R65-m2 9184302 VLGEKGRrIRELTAV KH_2 intracellular localization 19460357 1 0 0 regulates ribosome assembly -FEN1 FEN1 DNA repair, damage; DNA-binding; Deoxyribonuclease; EC 3.1.-.-; Nuclear receptor co-regulator; Nucleolus; Ribonuclease P39748 2237 11q12.2 human S187-p 2708400 MDCLTFGsPVLMRHL XPG_I sumoylation; protein degradation; protein stabilization; molecular association, regulation; intracellular localization; enzymatic activity, inhibited; enzymatic activity, induced cell cycle regulation; DNA repair, induced PCNA(DISRUPTS) 12853968; 18443037; 20729856; 22749529; 33770148 5 2 0 Interaction with early protein (IE1) of HCMV AD169 virus increases FEN1 phosphorylation and enhances its stability -Pld2 PLD2 EC 3.1.4.4; Lipid Metabolism - ether lipid; Lipid Metabolism - glycerophospholipid; Motility/polarity/chemotaxis; Phospholipase P97813 18806 11 B3|11 42.99 cM mouse Y14-p 453410 NLFPYGDyLNSSQLH intracellular localization 15282299 1 0 0 Y14 F and YallF showed altered location in cytoplasm rather than at the plasmamembrane. -Pxn PXN Adaptor/scaffold; Cell adhesion; Cytoskeletal; Motility/polarity/chemotaxis Q8VI36 19303 5 F|5 56.1 cM mouse S130-p 450228 KQKSAEPsPTVMSSS Paxillin cell motility, altered; cytoskeletal reorganization 16537926 5 25 4 regulates cells spreading -FFAR4 GPR120 GPCR, family 1; Lipid-binding; Membrane protein, integral; Membrane protein, multi-pass; Receptor, GPCR Q5NUL3 338557 10q23.33 human T347-p 31014807 PEKGAILtDTSVKRN activity, induced 27852822 5 1 0 -Olig2 OLIG2 Oncoprotein; Transcription factor Q9EQW6 50913 16 C3.3|16 52.6 cM mouse S14-p 18357901 LVSSRPSsPEPDDLF cell cycle regulation; cell differentiation, altered; carcinogenesis, altered; cell growth, induced; apoptosis, inhibited; transcription, induced; cell motility, inhibited 21382551; 27396340; 32483381 4 2 0 -ATF4 ATF-4 DNA-binding; Transcription factor P18848 468 22q13.1 human T119-p 40420009 LLTTLDDtCDLFAPL protein degradation transcription, inhibited 25795775 1 1 0 -AQP9 AQP9 Channel, misc.; Membrane protein, integral; Membrane protein, multi-pass; Transporter; Transporter, aquaporin family O43315 366 15q21.3 human S11-p 477183 EGAEKGKsFKQRLVL intracellular localization cell motility, induced; cytoskeletal reorganization 17346701; 21873454 2 0 0 -Nfe2l2 NRF2 DNA-binding; Transcription factor Q60795 18024 2 C3|2 44.75 cM mouse S338-p 18258501 NDSDSGIsLNTSPSR protein degradation; molecular association, regulation; activity, inhibited carcinogenesis, induced BTRC(INDUCES) 21245377; 22751928; 22964642; 24892215 4 1 0 -H3c1 H3 DNA-binding P68433 360198 13|13 A3.1 mouse K79-m1 459011 REIAQDFkTDLRFQS Histone endocytosis, altered; chromatin organization, altered; cell adhesion, altered 19434510; 33195484 16 21 41 regulation of senescence-related epigenetics modification; axon guidance -IL17RA IL17RA Membrane protein, integral; Receptor, cytokine Q96F46 23765 22q11.1 human T780-p 41452470 MVLTDPHtPYEEEQR protein degradation; ubiquitination 26871944 1 2 0 -MYL12B MRLC2 Contractile O14950 103910 18p11.31 human S20-p 448595 KRPQRATsNVFAMFD intracellular localization cell motility, altered; cytoskeletal reorganization 11781833; 12429016; 12571246; 16038801; 18984162 62 64 295 -Mip AQP0 Channel, misc.; Membrane protein, integral; Membrane protein, multi-pass; Transporter, aquaporin family P09011 25480 7q11 rat S227-p 453400 LLFPRLKsVSERLSI molecular association, regulation 22194645 3 3 0 No differences in the interaction with filensin between the AQP0 COOH-terminal peptide and its pseudophosphorylated proteins -CDC25C CDC25C EC 3.1.3.48; Motility/polarity/chemotaxis; PHOSPHATASE; Protein phosphatase, dual-specificity P30307 995 5q31.2 human S198-p 448636 SDELMEFsLKDQEAK M-inducer_phosp intracellular localization 11897663 4 1 1 -RBBP8 CtIP EC 3.1.-.-; Transcription, coactivator/corepressor Q99708 5932 18q11.2 human T847-p 7113805 FRYIPPNtPENFWEV SAE2 cell cycle regulation; DNA repair, induced; cell growth, induced; chromatin organization, altered 19202191; 31097467 7 1 1 -Mapk9 JNK2 EC 2.7.11.24; KINASE; Kinase, protein; Protein kinase, CMGC; Protein kinase, Ser/Thr (non-receptor) Q9WTU6 26420 11|11 B1.2-B1.3 mouse S129-p 456485 ELDHERMsYLLYQML Pkinase enzymatic activity, induced 16061178 1 0 0 -GORASP1 GRASP65 Vesicle Q9BQQ3 64689 3p22.2 human S189-p 25247500 AAWGGEGsLGCGIGY GRASP55_65 molecular association, regulation; protein conformation GRASP65(DISRUPTS) 22523075 1 0 0 dimer formation inhibited- substitution of two residues Glu145 and S189 rescued dimer formation, membrane tethering inhibited -H3c1 H3 DNA-binding P68433 360198 13|13 A3.1 mouse K64-m3 10338221 STELLIRkLPFQRLV Histone chromatin organization, altered; transcription, inhibited 19561610 2 0 0 -Ripk3 RIPK3 EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, Ser/Thr (non-receptor); Protein kinase, TKL Q9QZL0 56532 14|14 C3 mouse K5-ub 41259005 ___MSSVkLWPTGAS molecular association, regulation RIPK1(INDUCES) 25939025 1 2 0 induces necroptosis-mediated cell death -NEDD1 NEDD1 Cell cycle regulation Q8NHV4 121441 12q23.1 human S405-p 4706050 FDDTGKSsLGDMFSP intracellular localization cell cycle regulation; chromatin organization, altered; cytoskeletal reorganization 23273898; 31028180 3 6 1 microtubule nucleation at the central spindle during Anaphase; microtubule nucleation (vicinity of chromosomes) & spindle assembly, functional K-fibre formation, RANGTP aster formation -Vim Vimentin Cytoskeletal; Motility/polarity/chemotaxis P20152 22352 2 A1|2 10.04 cM mouse S25-p 455453 SGTSSRPsSNRSYVT Filament_head cytoskeletal reorganization 12458200 2 20 1 -DLC1 DLC1 GAP; GAP, Rac/Rho; Tumor suppressor Q96QB1 10395 8p22 human S859-p 37038505 RRENSSDsPKELKRR activity, induced; intracellular localization; protein conformation carcinogenesis, inhibited; cell growth, inhibited; cell motility, inhibited talin 1(INDUCES); tensin 1 iso1(INDUCES) 25452387 1 1 0 localize to focal adhesions; activates Rho-GAP activity -EIF4EBP1 4E-BP1 Translation; Translation initiation Q13541 1978 8p11.23 human T70-p 447528 RNSPVTKtPPRDLPT eIF_4EBP molecular association, regulation; protein conformation; activity, inhibited; phosphorylation cell cycle regulation; carcinogenesis, induced; cell motility, induced; transcription, altered; translation, altered; cell growth, induced; autophagy, inhibited; translation, induced; translation, inhibited 4E-BP1(DISRUPTS); EIF4E(DISRUPTS) 11410517; 11553333; 12588975; 15051500; 24247720; 25702871; 26170285; 27065332; 33658337; 35626002 55 57 9 -PRKCE PKCE EC 2.7.11.13; KINASE; Kinase, protein; Protein kinase, AGC; Protein kinase, Ser/Thr (non-receptor) Q02156 5581 2p21 human S729-p 448789 QEEFKGFsYFGEDLM Pkinase_C sumoylation; molecular association, regulation; intracellular localization; enzymatic activity, induced cell growth, induced AKAP9(DISRUPTS) 10945988; 11964154; 21806543; 33027667 20 17 7 -TRPC6 TRPC6 Channel, cation; Membrane protein, integral; Membrane protein, multi-pass Q9Y210 7225 11q22.1 human S14-p 4959823 FGPRRGSsPRGAAGA intracellular localization 28877958 2 2 2 plasma membrane expression -Ywhaz 14-3-3 zeta Adaptor/scaffold; Motility/polarity/chemotaxis P63101 22631 15|15 B3.1 mouse S58-p 449833 VVGARRSsWRVVSSI 14-3-3 molecular association, regulation; intracellular localization apoptosis, induced 14-3-3 zeta(DISRUPTS) 12865427; 20813501; 21189996 15 1 5 -GATA1 GATA1 DNA-binding; Transcription factor P17678 396450 chicken K220-ac 459194 RKVSSKGkKRRPPGG molecular association, regulation; protein conformation cell differentiation, induced; transcription, induced DNA(INDUCES) 9859997 3 1 0 -TP63 p63 DNA-binding; Transcription factor Q9H3D4 8626 3q28 human K232-ac 41259001 IRAMPVYkKAEHVTE P53 protein stabilization transcription, induced 25911675 1 0 0 -CDK5 CDK5 Cell cycle regulation; EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, CMGC; Protein kinase, Ser/Thr (non-receptor) Q00535 1020 7q36.1 human S159-p 448021 GIPVRCYsAEVVTLW Pkinase enzymatic activity, induced 10500146 6 0 0 Cdk5 is activated after phosphorylation by CK1 in vitro. -JUN Jun Oncoprotein; Transcription factor P05412 3725 1p32.1 human S73-p 447943 VGLLKLAsPELERLI Jun activity, induced; acetylation; protein stabilization; molecular association, regulation; enzymatic activity, induced cell cycle regulation; carcinogenesis, induced; cell motility, induced; cell growth, induced; transcription, induced; transcription, altered; cell growth, altered TCF4(INDUCES); HDAC3(DISRUPTS); JNK1(DISRUPTS); MBD3(DISRUPTS); PIN1(INDUCES); NFkB-p65(INDUCES) DNA(INDUCES); DNA(DISRUPTS) 11313929; 11432833; 11739718; 12040039; 12853483; 1496019; 15378002; 18443042; 19118012; 1922387; 20395206; 23720779; 26745678; 26755651; 33767435; 34703881; 36253406; 7737130; 7744008; 8072547; 8224842; 9022811 84 65 16 -SAMHD1 SAMHD1 EC 3.1.4.- Q9Y3Z3 25939 20q11.23 human K354-ac 1883981500 LRICARDkEVGNLYD acetylation; intracellular localization DNA repair, inhibited 36344525 1 1 0 deacetylation promotes genome stability; K354 deacetylation facilitates SAMHD1 localization to DSBs and SAMHD1 residues 300?465; K354 deacetylation by SIRT1 promotes HR and DNA end resection -NCOA3 SRC-3 ACETYLTRANSFERASE; Acetyltransferase; EC 2.3.1.48; Motility/polarity/chemotaxis; Nuclear receptor co-regulator; Transcription, coactivator/corepressor Q9Y6Q9 8202 20q13.12 human S509-p 482840 GVHSPMAsSGNTGNH NCOA_u2 activity, induced; protein degradation; molecular association, regulation; ubiquitination; phosphorylation transcription, induced; signaling pathway regulation ER-alpha(INDUCES) 17574025 1 0 0 induces ubiquitination, degradation of SRC-3, and its interaction with ER. -JUNB JunB Motility/polarity/chemotaxis; Oncoprotein; Transcription factor P17275 3726 19p13.13 human S251-p 465702 QTVPEARsRDATPPV Jun protein degradation FBXW7(INDUCES) 22710716 1 37 7 mitosis progression and chromatid cohesion -RG1 PPP1R3A Membrane protein, integral; Protein phosphatase, regulatory subunit Q00756 100009140 rabbit S67-p 449321 SSGGRRVsFADNFGF molecular association, regulation PPP1CA(DISRUPTS) 10657242 6 1 0 -RRAGC RRAGC Q9HB90 64121 1p34.3 human T394-p 6732849 KALTHNGtPRNAI__ molecular association, regulation; phosphorylation cell growth, induced; autophagy, inhibited Raptor(INDUCES); mTOR(DISRUPTS) 30552228 1 13 18 induces Ulk1 and p70S6K phosphorylation, regulates mTORC1 raptor complex stability -LASP1 Lasp-1 Actin-binding; Motility/polarity/chemotaxis Q14847 3927 17q12 human S146-p 448836 MEPERRDsQDGSSYR molecular association, regulation; intracellular localization; protein conformation; phosphorylation carcinogenesis, induced Zyxin(DISRUPTS); LPP(INDUCES); AGO2(DISRUPTS); CXCR4(INDUCES); Akt1(INDUCES) 12571245; 22665060; 32075106; 32872485 6 33 135 inhibits phosphorylation at Y171 -EXO5 DEM1 EC 3.1.11.- Q9H790 64789 1p34.2 human T88-p 1874115104 LYVTDLAtQNWCELQ Exo5 molecular association, regulation; enzymatic activity, inhibited DNA repair, induced BLM(INDUCES) DNA(DISRUPTS) 34197737 1 0 0 -H4C1 H4 DNA-binding P62805 8359 6p22.2 human Y72-p 475134 VIRDAVTyTEHAKRK CENP-T_C molecular association, regulation; methylation DNA repair, induced SUV420H1(INDUCES); SETD8(INDUCES); EGFR(DISRUPTS) 25073158 1 7 145 disruption of interaction with EGFR and reduced tumor mass in mice treated with the Y72 peptide -CSNK1D CK1D EC 2.7.11.1; EC 2.7.11.26; KINASE; Kinase, protein; Protein kinase, CK1; Protein kinase, Ser/Thr (non-receptor) P48730 1453 17q25.3 human T347-p 3190852 VAPPTPLtPTSHTAN enzymatic activity, induced 28545154 1 15 7 -Pdgfrb PDGFRB EC 2.7.10.1; KINASE; Kinase, protein; Membrane protein, integral; Oncoprotein; Protein kinase, TK; Protein kinase, tyrosine (receptor) P05622 18596 18 E1|18 34.41 cM mouse Y578-p 447521 VSSDGHEyIYVDPVQ molecular association, regulation PLCG1(INDUCES) 11281646 11 1 0 -MEFV pyrin Actin-binding O15553 4210 16p13.3 human S209-p 455898 RLRRNASsAGRLQGL molecular association, regulation; intracellular localization 14-3-3 theta(INDUCES) 15934090 2 0 0 -NCL NCL DNA-binding; Helicase; Nuclear receptor co-regulator; Nucleolus; RNA-binding P19338 4691 2q37.1 human T76-p 483581 TKKVAVAtPAKKAAV molecular association, regulation cell cycle regulation; cell motility, induced; cell growth, induced DDX31(INDUCES) 29440146; 30320343; 37276927 5 33 23 -CTCF CTCF C2H2-type zinc finger protein; Transcription factor; Tumor suppressor P49711 10664 16q22.1 human K74-sm 6124703 DPTLLQMkTEVMEGT transcription, induced 22354964 2 1 0 -Creb1 CREB iso1 DNA-binding; Transcription factor P15337-1 81646 9q32 rat S129-p 450092 QKRREILsRRPSYRK pKID transcription, induced 11796524; 12162494; 7798217 10 0 2 Ser to Ala substitution of residue 129 impairs cAMP-induced transcriptional response -DOC2B DOC2B Lipid-binding Q14184 8447 17p13.3 human Y301-p 5466714 AAMDANGySDPYVKT C2 molecular association, regulation KLC1(INDUCES) 30707251 1 0 1 increase GLUT4 translocation, important for Glucose uptake and protect cells against InsRes stimuli -Ppargc1a PGC-1 alpha Nuclear receptor co-regulator; Transcription, coactivator/corepressor O70343 19017 5|5 C1 mouse T256-p 13861600 HAQAKPTtLSLPLTP intracellular localization transcription, induced 20351112 1 0 0 -Asf1a ASF1A DNA repair, damage; Histone-binding Q9CQE6 66403 10|10 B3 mouse S166-p 3245981 KLEDAESsNPNLQSL cell differentiation, induced 28708136 2 11 2 -Apba1 APBA1 Adaptor/scaffold B2RUJ5 319924 19|19 B mouse Y202-p 23082644 GGLQEHVyEEIGDAP intracellular localization 26865271 1 1 6 neuronal trafficking of amyloid precursor protein (APP) -PJA2 PJA2 EC 6.3.2.-; EC 6.3.2.19; Ligase; UBIQUITIN LIGASE; Ubiquitin conjugating system; Ubiquitin ligase O43164 9867 5q21.3 human S342-p 18713700 RHEAKQRsVQRWREA ubiquitination; enzymatic activity, induced signaling pathway regulation 21423175 1 0 0 S342A/T389A mutant fails to ubiquitylate PKAR2A in vitro -SP1 SP1 C2H2-type zinc finger protein; DNA-binding; Transcription factor P08047 6667 12q13.13 human S732-p 2535903 PLDSGAGsEGSGTAT protein degradation; molecular association, regulation; ubiquitination cell growth, inhibited; apoptosis, induced; signaling pathway regulation; transcription, inhibited BTRC(INDUCES) 18239466; 19372209; 30181396 3 0 0 also inhibits stabilization of B-Catennin thus regulating Wnt signaling -Esr2 ER-beta DNA-binding; Nuclear receptor O08537 13983 12 C3|12 33.52 cM mouse S61-gl 5148302 MNYSVPSsTGNLEGG ERbeta_N protein degradation; protein stabilization; protein conformation transcription, altered 11150304; 16984883 2 1 0 phosphorylation results in accelerated degradation, while O-Glycosylation would be predicted to result in stabilization, both localized in nucleus -SGK1 SGK1 EC 2.7.11.1; KINASE; Kinase, protein; Motility/polarity/chemotaxis; Protein kinase, AGC; Protein kinase, Ser/Thr (non-receptor) O00141 6446 6q23.2 human S422-p 448429 AEAFLGFsYAPPTDS Pkinase_C molecular association, regulation; intracellular localization; phosphorylation; enzymatic activity, induced cell cycle regulation; cell growth, inhibited; apoptosis, inhibited; transcription, inhibited; signaling pathway regulation 10191262; 11096081; 11832334; 11956329; 18456663; 19232516; 25384981; 30837283; 33890983; 34679726; 35588785 30 0 0 induces NDRG1 phosphorylation -Msx1 MSX1 DNA-binding; Motility/polarity/chemotaxis P13297 17701 5 B3|5 20.21 cM mouse K133-sm 12004421 LPEDALVkAESPEKL cell differentiation, inhibited; transcription, inhibited 16600910 2 0 0 PIAS1 binding to MSX1 is required for inhibiting cell differentiation and transcriptional repression, but sumoylation is not required -NHERF1 NHERF Adaptor/scaffold; Motility/polarity/chemotaxis O14745 9368 17q25.1 human S77-p 957200 ETHQQVVsRIRAALN PDZ molecular association, regulation; intracellular localization SLC34A1(DISRUPTS); ADRA2B(DISRUPTS) 17895247; 20571032 4 0 0 -Gabrb2 GABRB2 Channel, chloride; Channel, ligand-gated; Membrane protein, integral; Membrane protein, multi-pass; Transporter; Transporter, ion channel P63138 25451 10q21 rat S434-p 449329 SRLRRRAsQLKITIP Neur_chan_memb intracellular localization 12818177 1 0 1 -SP3 SP3 C2H2-type zinc finger protein; DNA-binding Q02447 6670 2q31.1 human K120-sm 3681500 SATPTTIkDEAGNLV intracellular localization; activity, inhibited transcription, inhibited 12419227 1 1 0 -ZFP36 TTP DNA-binding; RNA-binding P26651 7538 19q13.2 human S186-p 451151 PVLRQSIsFSGLPSG protein degradation; molecular association, regulation; ubiquitination carcinogenesis, induced; RNA stability, induced RNA(INDUCES) 28548957; 37210725 13 25 11 -MAPK14 P38A EC 2.7.11.24; KINASE; Kinase, protein; Protein kinase, CMGC; Protein kinase, Ser/Thr (non-receptor) Q16539 1432 6p21.31 human T180-p 447970 RHTDDEMtGYVATRW Pkinase activity, induced; molecular association, regulation; phosphorylation; enzymatic activity, induced cell cycle regulation; carcinogenesis, induced; apoptosis, altered; apoptosis, induced; signaling pathway regulation; cell growth, induced; cell motility, altered; transcription, inhibited; carcinogenesis, inhibited; cell growth, inhibited; transcription, induced; autophagy, induced; cell differentiation, induced; cytoskeletal reorganization; cell adhesion, altered; autophagy, inhibited PPP2CA(NOT_REPORTED); NCK1(INDUCES); MEK1(NOT_REPORTED); Fyn(INDUCES); P38A(INDUCES) 10201954; 10867021; 11994493; 15944157; 15972258; 16966330; 17438131; 17548358; 18047584; 18560558; 19336399; 21177868; 21878628; 22039048; 33685990; 34048499; 34209868; 34995286; 35189144; 35569509; 35849202; 36219392; 36289618; 8622669 401 73 1542 autoamplifcation of NFAT-c1, which promotes osteoclast differentiation, suppressed by MLN4924 -API5 API5 Apoptosis; RNA-binding Q9BZZ5 8539 11p12 human K251-ac 11322946 QAVPLFSkNVHSTRF API5 protein stabilization; intracellular localization cell cycle regulation 34385547 1 1 0 nuclear localization -Notch1 Notch 1 Membrane protein, integral; Motility/polarity/chemotaxis; Oncoprotein; Receptor, misc.; Transcription factor Q01705 18128 2 A3|2 18.91 cM mouse S2152-p 3252805 GKKARKPsTKGLACG intracellular localization cell motility, induced; cell growth, induced 27281612 1 2 3 nuclear localization -OCLN occludin Cell adhesion; Membrane protein, integral; Membrane protein, multi-pass; Motility/polarity/chemotaxis Q16625 100506658 5q13.2 human T424-p 19083406 IREYPPItSDQQRQL Occludin_ELL intracellular localization 21545357 1 0 0 facilitates assembly of occludin into tight junction -CHUK IKKA EC 2.7.11.10; KINASE; Kinase, protein; Protein kinase, Other; Protein kinase, Ser/Thr (non-receptor) O15111 1147 10q24.31 human S473-p 487499 KNTLISAsQQLKAKL IKBKB_SDD protein stabilization 17700524 1 0 0 -KCNC4 Kv3.4 Channel, potassium; Membrane protein, integral; Membrane protein, multi-pass Q03721 3749 1p13.3 human S15-p 451077 SSYRGRKsGNKPPSK Potassium_chann receptor inactivation, altered; protein conformation; activity, inhibited 7993631; 9649584 2 0 0 -DBF4 DBF4 Cell cycle regulation; Protein kinase, regulatory subunit Q9UBU7 10926 7q21.12 human T449-p 23010416 DDIRQNFtQLPLHKN cell cycle regulation 22123827 1 0 0 DBF4 phosphorylaion is important for supressing DNA replication. -TERF1 TRF1 DNA-binding P54274 7013 8q21.11 human T344-p 3793900 KKERRVGtPQSTKKK phosphorylation 18625707 2 1 0 stimulates phosphorylation of residue S435 -Acly ACLY Carbohydrate Metabolism - citrate (TCA) cycle; EC 2.3.3.8; Lyase; Transferase Q91V92 104112 11|11 D mouse S455-p 448631 PAPSRTAsFSESRAD transcription, inhibited 33865855 10 83 122 -BAP1 BAP1 DEUBIQUITINASE; EC 3.4.19.12; Protease; Tumor suppressor; Ubiquitin conjugating system; Ubiquitin-specific protease Q92560 8314 3p21.1 human S583-p 482082 TEGGKGSsPSIRPIQ intracellular localization DNA repair, induced 24347639 1 8 3 -Kirrel1 KIRREL Cell adhesion; Membrane protein, integral Q80W68 170643 3|3 F1 mouse Y638-p 463752 KDPTNGYyNVRAHED molecular association, regulation cytoskeletal reorganization GRB2(INDUCES) 17923684; 34391780 3 5 49 induce podocyte repair -H3-3A H3F3A DNA-binding P84243 3020 1q42.12 human K27-ac 18545312 LATKAARkSAPSTGG Histone phosphorylation 16185088 1 3 21 detecting S10 phosphorylation with phospho-antibody was disrupted in dual modified peptides with K9ac and K9 monomethyl as was S28 with K27ac -Odf1 ODFP1 Cancer Testis Antigen (CTA) P21769 24610 7q22 rat S193-p 2859801 SPCYPCTsPCNPCNP molecular association, regulation RNF38(INDUCES) 17762160 1 0 0 -TSC1 TSC1 Motility/polarity/chemotaxis; Tumor suppressor Q92574 7248 9q34.13 human S468-p 36132604 GFLGDLAsEEDSIEK Hamartin intracellular localization cell cycle regulation; cell growth, altered 29559472 1 2 0 decreased lysosomal localization of the TSC complex -EPHB2 EphB2 EC 2.7.10.1; KINASE; Kinase, protein; Membrane protein, integral; Protein kinase, TK; Protein kinase, tyrosine (receptor); Tumor suppressor P29323 2048 1p36.12 human Y504-p 139835700 GLKAGAIyVFQVRAR fn3 molecular association, regulation; intracellular localization NMDAR1(INDUCES) 28719605 1 1 0 cell surface,retain NMDARs to spine synapse, pathological pain, mechanical hypersensitivity -IQGAP1 IQGAP1 GAP; GAP, Ras; Motility/polarity/chemotaxis P46940 8826 15q26.1 human S1443-p 454416 DKMKKSKsVKEDSNL molecular association, regulation; protein conformation; phosphorylation cytoskeletal reorganization; cell adhesion, inhibited; endocytosis, inhibited RAC1(DISRUPTS); CDC42 iso1(DISRUPTS); CDC42(INDUCES); RAC1(INDUCES); RAB27A(DISRUPTS) 15355962; 15695813; 21349850; 27815503; 28739799; 31474712 5 17 3 glucose-induced endocytosis -HDAC6 HDAC6 DEACETYLASE; Deacetylase; EC 3.5.1.98; Nuclear receptor co-regulator; Ubiquitin conjugating system Q9UBN7 10013 Xp11.23 human Y570-p 12127406 SSNFDSIyICPSTFA Hist_deacetyl enzymatic activity, inhibited 20029029 1 0 1 -Nr1h3 LXR-alpha DNA-binding; Motility/polarity/chemotaxis; Nuclear receptor Q9Z0Y9 22259 2 E1|2 50.52 cM mouse K326-sm 12004412 YNREDFAkAGLQVEF Hormone_recep protein degradation; ubiquitination 33125792 2 0 0 Sumoylation of LXR-alpha is necessary for polyubiquitylation and interaction with pSTAT1 and PIAS1 for degradation induced by IFN-gamma. May inhibit cholesterol effux mediated by ABCG1 from macrophages. -Nkx3-2 NKX3-2 Cell development/differentiation; DNA-binding; Transcription factor P97503 12020 5 B3|5 22.58 cM mouse S168-p 20473602 RGEDDSVsPGGARVP molecular association, regulation; ubiquitination apoptosis, inhibited BTRC(INDUCES) 21606193 1 1 0 phosphorylation of S148/S168 causes ubiquitination of IkB-alpha. -INSR INSR EC 2.7.10.1; KINASE; Kinase, protein; Membrane protein, integral; Protein kinase, TK; Protein kinase, tyrosine (receptor) P06213 3643 19p13.2 human S1333-p 451591 NVPLDRSsHCQREEA enzymatic activity, inhibited 8454604 2 0 0 -ELAVL1 HuR RNA-binding Q15717 1994 19p13.2 human S158-p 478356 FIRFDKRsEAEEAIT RRM_1 molecular association, regulation; intracellular localization; phosphorylation translation, altered; RNA stability, altered PKCA(INDUCES) RNA(INDUCES) 17392515; 23978401 3 0 0 ELAV1 is exported from the nucleus after phosphorylation by PKCA. ; increased binding to U-rich RNA but not AU-rich sequences -Mapk7 ERK5 EC 2.7.11.24; KINASE; Kinase, protein; Protein kinase, CMGC; Protein kinase, Ser/Thr (non-receptor) Q9WVS8 23939 11|11 B2 mouse K6-sm 2887213 __MAEPLkEEDGEDG molecular association, regulation apoptosis, induced; transcription, inhibited; signaling pathway regulation SRC-1(DISRUPTS) 18218985; 18467627 4 0 0 -ARFIP2 arfaptin 2 GAP; GAP, Rac/Rho; Motility/polarity/chemotaxis P53365 23647 11p15.4 human S260-p 455884 GTRGRLEsAQATFQA Arfaptin intracellular localization 15809304 1 3 4 phosphorylation of site by Akt1 has a neuroprotective effect in Huntington's disease. -TENT2 PAPD4 EC 2.7.7.19; RNA processing; Transferase Q6PIY7 167153 5q14.1 human S116-p 50785745 LSGERRYsMPPLFHT molecular association, regulation; enzymatic activity, inhibited; enzymatic activity, altered RNA stability, altered RNA(DISRUPTS) 31057087; 34288801 2 2 0 -CD300LF IREM-1 Immunoglobulin superfamily; Membrane protein, integral; Receptor, misc. Q8TDQ1 146722 17q25.1 human Y263-p 474549 AEDQEPTyCNMGHLS activity, induced; molecular association, regulation PIK3R1(INDUCES) 17202342 2 0 0 involved in rat basophilic leukemia cell degranulation -JUNB JunB Motility/polarity/chemotaxis; Oncoprotein; Transcription factor P17275 3726 19p13.13 human Y188-p 41655505 VYTNLSSySPASASS Jun transcription, induced 26217035 1 1 0 p21 promoter activity upon Adriamycin stimulation -Pdx1 PDX1 DNA-binding; Transcription factor P52946 18609 5 G3|5 86.84 cM mouse S269-p 11279404 LPSGLSVsPQPSSIA protein stabilization; intracellular localization 20637728; 23331010 3 4 0 -SPRR2B SPRR2B P35325 6701 1q21.3 human Y67-p 5233872 SPPCQPKyPPKSK__ SPRR2 molecular association, regulation cell cycle regulation USP7(INDUCES) 29581288 1 0 1 facilitated complex formation with USP7 and p53 degradation in response to TGF-beta1/H2O2 -Map2 MAP2 iso3 Cytoskeletal; Motility/polarity/chemotaxis P15146-3 25595 9q32 rat K347-ac 62495516 DLSHVTSkCGSLKNI Tubulin-binding cytoskeletal reorganization 28002468 1 1 0 -Mcl1 MCL1 Apoptosis; Channel, misc.; Inhibitor; Membrane protein, integral; Mitochondrial P97287 17210 3 F2.1|3 40.74 cM mouse S140-p 460683 KSSGADGsLPSTPPP protein degradation; molecular association, regulation; ubiquitination autophagy, induced beclin 1(DISRUPTS) 26822034; 28053206 17 7 2 dissasociates after phosphorylation and ubiquitylation of MCL1 at K117, K175, K178 -Tln1 talin 1 Cytoskeletal; Motility/polarity/chemotaxis P26039 21894 4|4 A5 mouse S1589-p 27533485 SSVPAQIsPEGRAAM molecular association, regulation; protein conformation ANKRD15(DISRUPTS) 34118235 1 7 0 -CTBP1 CTBP1 Cell cycle regulation; EC 1.1.1.-; Nuclear receptor co-regulator; Oxidoreductase; Transcription, coactivator/corepressor Q13363 1487 4p16.3 human S100-p 2089801 RIIVRIGsGFDNIDI 2-Hacid_dh molecular association, regulation SF1(INDUCES) 18184656 1 1 0 -SUPT5H SPT5 RNA-binding; Transcription, coactivator/corepressor O00267 6829 19q13.2 human T799-p 458818 PLQDGSRtPHYGSQT transcription, altered 16427012 1 9 40 required for c-fos induction and activation in vivo -CENPU CENPU Cell cycle regulation Q71F23 79682 4q35.1 human T78-p 471408 FDPPLHStAIYADEE protein degradation; molecular association, regulation; intracellular localization cell cycle regulation; carcinogenesis, induced; cell motility, induced; cell growth, induced; signaling pathway regulation; cell growth, altered CENPQ(INDUCES); PLK1(INDUCES) 17081991; 21454580; 34094674; 34551298 4 1 0 COX-2/HIF-1a/VEGFA signaling pathway; PLK1 phosphorylates CENPU T78 and then is recruited to form a ternary complex with CENPU and CENPQ, then PLK1 phosphorylates CENPQ which dissasociates the complex.; p-T78 peptides precipitated with Pl1K. Kinase activity of Plk1 is necessary for the in vivo interaction. The S77- T78 dependent interaction is sufficient to target Plk1 to the kinetochores. P-T78 dependent PBIP1 function is required for chromosome segregation, and is important for activation of spindle assembly checkpoint.; induces PLK1 recruitment -Pparg PPAR-gamma DNA-binding; Nuclear receptor; Transcription factor P37238 19016 6 E3|6 53.41 cM mouse K268-ub 1877844704 ARAILTGkTTDKSPF protein degradation; ubiquitination cell differentiation, inhibited 31653699 1 1 0 -IKZF1 Ikaros C2H2-type zinc finger protein; DNA-binding; Transcription factor Q13422 10320 7p12.2 human S391-p 451350 SEREASPsNSCQDST cell cycle regulation; cell growth, induced 27026320 2 1 2 -SOX2 SOX2 Cell development/differentiation; DNA-binding; Transcription factor P48431 6657 3q26.33 human K115-ub 1878299900 YKYRPRRkTKTLMKK protein degradation 30894683 1 0 0 AKT1 phosphorylation at T116 blocks UBR5-induced ubiquitination at K115 of SOX2 -Gabrg2 GABRG2 Channel, chloride; Channel, ligand-gated; Membrane protein, integral; Membrane protein, multi-pass; Transporter; Transporter, ion channel Q6PW52 29709 10q21 rat Y411-p 455817 LQERDEEyGYECLDG Neur_chan_memb molecular association, regulation; receptor internalization, inhibited neural plasticity; endocytosis, inhibited Src(INDUCES); AP-2 alpha(DISRUPTS) 11640929; 18305175 7 0 0 -PDP1 PDP1 EC 3.1.3.43; Mitochondrial; Motility/polarity/chemotaxis; PHOSPHATASE; Protein phosphatase, Ser/Thr (non-receptor) Q9P0J1 54704 8q22.1 human K202-ac 11323780 HPNDYFSkEASKLYF PP2C molecular association, regulation cell growth, induced PDHA1(INDUCES) 24486017 2 2 0 glycolysis, cancer cell proliferation -HNRNPA1 hnRNP A1 Nuclear export; RNA splicing; RNA-binding; Spliceosome P09651 3178 12q13.13 human S4-p 468002 ____MSKsESPKEPE sumoylation; molecular association, regulation; intracellular localization apoptosis, inhibited; translation, induced 14-3-3 sigma(INDUCES); 14-3-3 theta(INDUCES) RNA(INDUCES) 25324306 2 48 2 interaction with BCL-XL and XIAP mRNA and regulation of their translation; nuclear import/export -Sort1 SORT1 Membrane protein, integral; Receptor, misc. Q6PHU5 20661 3|3 F2.3-F3 mouse S791-p 3823097 RFLVHRYsVLQQHAE protein degradation 24986865 3 8 0 -ACD ACD Adaptor/scaffold Q96AP0 65057 16q22.1 human S25-p 3208632 LGSETPSsPRAGQLL TPP1 molecular association, regulation; enzymatic activity, inhibited cell cycle regulation TERT(INDUCES) 23509301 1 19 1 shortened telomere length -Hes1 HES1 Cell development/differentiation; Motility/polarity/chemotaxis; Transcription factor Q04666 29577 11q22 rat S263-p 23298200 SVGPNAVsPSSGSSL protein stabilization 22302822 1 0 0 decreases AMPA-evoked calcium influx; supresses GluR1 expression at the synaptic membrane -Gria2 GluR2 Channel, calcium; Channel, ligand-gated; Membrane protein, integral; Membrane protein, multi-pass P23819 14800 3 E3|3 35.5 cM mouse Y876-p 452173 YKEGYNVyGIESVKI molecular association, regulation neural plasticity IQSEC1(DISRUPTS) 15240807; 20547133; 32071234 9 5 109 -Slc6a5 SLC6A5 Membrane protein, integral; Membrane protein, multi-pass; Transporter; Transporter, SLC family P58295 171148 1q22 rat K787-ub 27209761 GTSSLGLkLPVKDLE protein degradation; ubiquitination; intracellular localization endocytosis, induced; transcription, altered 23484054; 31628376 2 1 0 LNX2 mediated degradation was slower and seen after 48 hours, PKC regulation of SLC6A5 activity, modulation in the glycine transport activity of SLC6A5 -Sirt1 SIRT1 Apoptosis; DEACETYLASE; Deacetylase; EC 3.5.1.-; Nuclear receptor co-regulator Q923E4 93759 10|10 B4 mouse S651-p 6855924 GAEVYSDsEDDVLSS enzymatic activity, induced apoptosis, inhibited 19680552 2 0 0 deacetylates p53 K382 and NFkB-p65 -Kcnn4 KCNN4 Channel, potassium; Membrane protein, integral; Membrane protein, multi-pass Q9QYW1 65206 1q21 rat T348-p 452146 KMLAAIHtFRQVRLK CaMBD activity, inhibited 15243742 1 0 0 -RARA RARA DNA-binding; Nuclear receptor; Oncoprotein; Transcription factor P10276 5914 17q21.2 human K171-sm 10902801 KKKKEVPkPECSESY transcription, induced 19850744 1 0 0 -TLR3 TLR3 Membrane protein, integral; Receptor, cytokine O15455 7098 4q35.1 human Y858-p 25680401 FLEEIPDyKLNHALC TIR molecular association, regulation signaling pathway regulation TICAM1(INDUCES) 22810896 1 0 0 antiviral TLR3 signaling -Mapk14 P38A EC 2.7.11.24; KINASE; Kinase, protein; Protein kinase, CMGC; Protein kinase, Ser/Thr (non-receptor) P47811 26416 17 A3.3|17 14.85 cM mouse Y182-p 447971 TDDEMTGyVATRWYR Pkinase molecular association, regulation; protein conformation; phosphorylation; enzymatic activity, induced cell cycle regulation; carcinogenesis, inhibited; cell growth, inhibited; apoptosis, induced; cell motility, inhibited; transcription, induced; signaling pathway regulation; transcription, altered; cell growth, induced; cell differentiation, induced PKCZ(INDUCES) 10867029; 12032135; 15665819; 15975986; 16648139; 18669639; 21847090; 25098293; 26517532; 33798451; 34560245; 35112724; 35637461; 36310322; 36642184 410 123 3683 -G6PD G6PD Carbohydrate Metabolism - pentose phosphate pathway; Cell development/differentiation; EC 1.1.1.49; Other Amino Acids Metabolism - glutathione; Oxidoreductase P11413 2539 Xq28 human Y112-p 455132 NSYVAGQyDDAASYQ G6PD_N enzymatic activity, induced carcinogenesis, induced; cell growth, induced 33686238 1 12 344 -MRE11 MRE11A Cell cycle regulation; DNA repair, damage; DNA-binding; Deoxyribonuclease P49959 4361 11q21 human T597-p 4333497 SQRGRADtGLETSTR protein degradation 28967905 1 3 23 -Afap1l1 AFAP1L1 Unknown function Q8BZI0 106877 18|18 E1 mouse Y127-p 41691500 KPPPEDYyEEALPLG molecular association, regulation cell motility, induced; cytoskeletal reorganization VAV2(INDUCES) 26212012 1 0 0 -Cyld CYLD DEUBIQUITINASE; EC 3.4.19.12; Protease; Tumor suppressor; Ubiquitin conjugating system; Ubiquitin-specific protease Q80TQ2 74256 8|8 C3 mouse S414-p 4745557 SSENRFHsLPFSLTK CYLD_phos_site enzymatic activity, inhibited cell growth, induced; apoptosis, inhibited 19481526; 34887354 5 31 22 -ITGB3BP NRIF3 Cell adhesion; Motility/polarity/chemotaxis; Nuclear receptor co-regulator; Transcription, coactivator/corepressor Q13352 23421 1p31.3 human S28-p 2840505 SKITRKKsVITYSPT CENP-R activity, induced; molecular association, regulation apoptosis, induced; transcription, induced; cell growth, altered ER-alpha(INDUCES) 18521086; 25409762 2 2 0 -DNM1L DRP1 Apoptosis; EC 3.6.5.5; Endoplasmic reticulum; Hydrolase; Microtubule-binding; Mitochondrial; Motor O00429 10059 12p11.21 human Y368-p 15569023 CGGARICyIFHETFG Dynamin_M activity, induced 29022905 1 0 2 oxidative stress-induced cell death in primary cortical neuron; increased GTPase activity -Junb JunB Motility/polarity/chemotaxis; Oncoprotein; Transcription factor P24898 24517 19q11 rat S23-p 1814002 AAAGYGRsPGSLSLH Jun protein degradation cell cycle regulation; transcription, altered 10790372 1 7 0 Phosphorylation promoted degradation during the G2-M transition. JunB inhibition of cyclin D1 transcription is relieved by JunB protein degradation. -CAD CAD Amino Acid Metabolism - alanine, aspartate and glutamate; EC 2.1.3.2; EC 3.5.2.3; EC 6.3.5.5; Hydrolase; KINASE; Ligase; Nucleotide Metabolism - pyrimidine; Transferase P27708 790 2p23.3 human S1859-p 451247 PPRIHRAsDPGLPAE enzymatic activity, induced carcinogenesis, induced; cell growth, induced 23429703; 31391321; 35046532 11 88 86 -KCTD12 KCTD12 Unknown function Q96CX2 115207 13q22.3 human S243-p 18011104 ITVCGKTsLAKEVFG molecular association, regulation cell growth, induced CDK1(INDUCES) 28869606 1 2 0 -DAPK3 DAPK3 EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, CAMK; Protein kinase, Ser/Thr (non-receptor); Tumor suppressor O43293 1613 19p13.3 human T180-p 454890 EFKNIFGtPEFVAPE Pkinase enzymatic activity, induced 15611134 1 0 0 -FUS hnRNP P2 DNA-binding; Nuclear receptor co-regulator; Oncoprotein; RNA splicing; RNA-binding; SUMO LIGASE P35637 2521 16p11.2 human S61-p 3306334 SYSSYGQsQNTGYGT molecular association, regulation; protein conformation hnRNP P2(DISRUPTS) 28942918; 31805282 6 1 0 strongly reduced the effects of DNA-PK treatment on both hydrogel binding and droplet formation; inhibits amyloid segment aggregation, fibrillization and seeding processes; disrupt the intra and intermolecular interactions to inhibit the aggregation of R2 -Hnf4a HNF4 alpha DNA-binding; Nuclear receptor; Transcription factor P49698 15378 2 H3|2 84.32 cM mouse K458-ac 25336501 GAITTIVkPPSAIPQ protein degradation 33636024 2 2 0 SIRT2 interacts with HNF4-alpha and suppresses its degradation. Deacetylation is required for HNF-alpha stability. -Srsf1 SF2 RNA splicing; RNA-binding; Spliceosome NP_001103022 689890 10q26 rat S227-p 2303915 NSRSRSYsPRRSRGS intracellular localization 18658135 3 20 2 inhibits tau exon 10 inclusion, and increases 3R-tau production -Stmn1 STMN1 Cytoskeletal P13668 29332 5q36 rat S25-p 448555 QAFELILsPRSKESV Stathmin apoptosis, inhibited; cytoskeletal reorganization 25285524; 31933182 52 122 91 increase microtubule depolymerization -TRIM25 TRIM25 EC 6.3.2.19; EC 6.3.2.n3; Ligase; Nuclear receptor co-regulator; Transcription factor; UBIQUITIN LIGASE; Ubiquitin conjugating system; Ubiquitin ligase Q14258 7706 17q22 human Y278-p 450585 NSKFDTIyQILLKKK ubiquitination; enzymatic activity, induced transcription, induced; signaling pathway regulation 30100205 1 23 278 induces K63-linked polyubiquitination of RIG-I -Pik3r1 PIK3R1 KINASE; Kinase, lipid; Motility/polarity/chemotaxis P26450 18708 13 D1|13 53.92 cM mouse Y467-p 451144 SREYDRLyEEYTRTS PI3K_P85_iSH2 cell cycle regulation; carcinogenesis, induced; cell motility, induced; cell growth, induced; apoptosis, inhibited 36310322 14 52 2216 -ADRB1 ADRB1 GPCR, family 1; Membrane protein, integral; Membrane protein, multi-pass; Receptor, GPCR P08588 153 10q25.3 human S462-p 89117904 AAADSDSsLDEPCRP receptor internalization, induced; molecular association, regulation; intracellular localization ARRB1(INDUCES) 28472170 2 3 0 beta-arrestin recruitment to the ADRB1 -Eif3f eIF3-epsilon EC 3.4.19.12; Translation; Translation initiation Q9DCH4 66085 7|7 E3 mouse K321-ub 7388007 SLVNQVPkIVPDDFE MitMem_reg protein degradation 19073596 1 0 0 regulates skeletal muscle atrophy -TFE3 TFE3 DNA-binding; Oncoprotein; Transcription factor P19532 7030 Xp11.23 human S246-p 56653430 PTGSAPNsPMALLTI MITF_TFEB_C_3_N intracellular localization 32662822 1 2 0 -Psma3 PSMA3 EC 3.4.25.1; Protease; Proteasome complex P18422 29670 6q24 rat S250-p 451185 SLKEEDEsDDDNM__ protein stabilization 14583091 2 105 818 -ARFGEF1 ARFGEF1 GEF; GEF, ARF; Nucleolus Q9Y6D6 10565 8q13.2 human S883-p 459627 EIAGKKIsMKETKEL intracellular localization 16467138 1 0 0 -ECT2 ECT2 iso2 GEF; GEF, Rac/Rho; Motility/polarity/chemotaxis Q9H8V3-2 1894 3q26.31 human T790-p 1412327900 NTKDMDStLSRASRA intracellular localization 30542068 1 0 0 correlates with cytoplasmic localization -DDX5 DDX5 EC 3.6.4.13; Helicase; Nuclear receptor co-regulator; Nucleolus; RNA splicing; RNA-binding; Spliceosome P17844 1655 17q23.3 human S198-p 27807802 CRACRLKsTCIYGGA DEAD molecular association, regulation; intracellular localization cell growth, inhibited DROSHA(INDUCES) 23482664 1 1 0 micro-RNA processing, c-Myc abundance reduced -RAF1 RAF1 EC 2.7.11.1; KINASE; Kinase, protein; Oncoprotein; Protein kinase, Ser/Thr (non-receptor); Protein kinase, TKL P04049 5894 3p25.2 human Y340-p 447749 RGQRDSSyYWEIEAS molecular association, regulation; enzymatic activity, inhibited; phosphorylation; enzymatic activity, induced RAF1(DISRUPTS) 10998357; 11259591; 11274179; 12551923; 17998336; 18775988; 19595761; 7692235; 9689060 29 1 1 -NFATC3 NFAT4 DNA-binding; Transcription factor Q12968 4775 16q22.1 human S215-p 11507604 PLTSPGGsPGGCPGE intracellular localization 9630228 1 0 0 cytoplasmic localization (inhibition of nuclear localization) -CASP8 CASP8 Apoptosis; EC 3.4.22.61; Protease Q14790 841 2q33.1 human T273-p 56640300 DAGALTTtFEELHFE Peptidase_C14 enzymatic activity, induced 27325299 4 0 0 -TAB1 TAB1 Activator; Motility/polarity/chemotaxis Q15750 10454 22q13.1 human K335-ub 1881312005 QAVVDRVkRIHSDTF signaling pathway regulation 34017102 1 0 0 TRIM26 enhances TLRs-induced NF-kB and MAPK signaling. -Idh2 IDH2 Carbohydrate Metabolism - citrate (TCA) cycle; EC 1.1.1.42; Mitochondrial; Other Amino Acids Metabolism - glutathione; Oxidoreductase P54071 269951 7 D2|7 45.43 cM mouse K256-ac 11320276 STKNTILkAYDGRFK Iso_dh protein stabilization; enzymatic activity, inhibited; protein conformation 28852116 1 4 0 K256Q mutant had lower activity than WT-pocket size decreased -CCNT1 CCNT1 Cell cycle regulation; Transcription initiation complex O60563 904 12q13.11-q13.12 human K390-ac 11322420 PSAKVSLkEYRAKHA molecular association, regulation; enzymatic activity, induced transcription, induced BCDIN3(DISRUPTS); HEXIM1(DISRUPTS); BRD4(INDUCES) RNA(DISRUPTS) 19387490; 19828451; 22084242 3 2 0 enhances CDK9/cyclin T1 transcriptional activity, disrupting HEXIM1 and BCDIN3 association; Interaction with BRD4 disrupts interaction with HEXIM1 and 7SK snRNA -CCNA2 CCNA2 Cell cycle regulation; Nuclear receptor co-regulator P20248 890 4q27 human K91-ub 1878249906 HVTVPPWkANSKQPA protein degradation cell cycle regulation 31413110 1 0 0 -Eif2b5 eIF2B-epsilon Translation; Translation initiation Q64350 192234 11q23 rat S713-p 449908 REAEEESsDDD____ W2 molecular association, regulation eIF2-alpha(INDUCES) 11500362 3 9 2 -Dynlt1 DYNLT1 Microtubule-binding; Motility/polarity/chemotaxis; Motor Q9Z336 83462 1q11 rat T94-p 456225 SSTDGSCtVRWENKT Tctex-1 molecular association, regulation 15992542 7 0 0 -F2RL1 F2RL1 GPCR, family 1; Membrane protein, integral; Membrane protein, multi-pass; Receptor, GPCR P55085 2150 5q13.3 human S387-p 15426050 SRKSSSYsSSSTTVK receptor desensitization, induced; molecular association, regulation; phosphorylation signaling pathway regulation ARRB1(INDUCES); ARRB2(INDUCES) 33073187 1 2 1 inhibits ERK phosphorylation and signaling; regulates calcium signaling -Gprc5b GPRC5B GPCR, family 3; Membrane protein, integral; Membrane protein, multi-pass; Receptor, GPCR Q923Z0 64297 7|7 F2 mouse Y330-p 3972629 EMHLPRAyMENKAFS molecular association, regulation Fyn(INDUCES) 23169819 1 2 1 induces phosphorylation of Cav1 and inflammatory signaling in adipose tissue -SMN1 SMN RNA processing; RNA-binding Q16637 6606 5q13.2 human T85-p 20503415 NKSQKKNtAASLQQW SMN molecular association, regulation; intracellular localization SIP1(DISRUPTS); coilin(INDUCES); GEMIN8(DISRUPTS) 21609790; 24602413 2 5 0 -Tdg TDG DNA repair, damage; EC 3.2.2.29; Hydrolase; Nuclear receptor co-regulator P56581 21665 10 C1|10 39.72 cM mouse K95-ac 458995 KKPATSKkSGKSTKS molecular association, regulation; acetylation; phosphorylation DNA repair, induced; chromatin organization, altered; DNA repair, inhibited; transcription, induced APE1(DISRUPTS) DNA(DISRUPTS) 11864601; 19966277 2 1 1 inhibits phosphorylation at other sites; histone acetylation -Ets1 Ets-1 DNA-binding; Motility/polarity/chemotaxis; Oncoprotein; Transcription factor P27577 23871 9 A4|9 17.97 cM mouse T38-p 447950 CADVPLLtPSSKEMM protein conformation transcription, induced CBP(INDUCES) 11948414; 20534573; 28716922 14 4 5 -MAFA MAFA DNA-binding; Oncoprotein; Transcription factor; Tumor suppressor Q8NHW3 389692 8q24.3 human T134-p 456029 NPEALNLtPEDAVEA Maf_N protein degradation signaling pathway regulation 19407223; 23660596 4 2 0 Ubiquitin proteosomal pathway -PDGFRA PDGFRA EC 2.7.10.1; KINASE; Kinase, protein; Membrane protein, integral; Oncoprotein; Protein kinase, TK; Protein kinase, tyrosine (receptor) P16234 5156 4q12 human Y762-p 448440 SDIQRSLyDRPASYK PK_Tyr_Ser-Thr molecular association, regulation; phosphorylation; enzymatic activity, induced signaling pathway regulation CRKL(INDUCES); CDK6(INDUCES) 33626330; 9546424 4 13 321 induces AKT phosphorylation and signaling -MACF1 ACF7 Actin-binding; Cytoskeletal; Motility/polarity/chemotaxis Q9UPN3 23499 1p34.3 human S7326-p 18507011 RAGSRASsRRGSDAS intracellular localization cell motility, induced; cytoskeletal reorganization 21295697 1 2 3 inhibits localization along microtubules, alters organization of microtubules, regulates skin wound repair, SC migration -Akt1 Akt1 EC 2.7.11.1; KINASE; Kinase, protein; Oncoprotein; Protein kinase, AGC; Protein kinase, Ser/Thr (non-receptor) P31750 11651 12 F1|12 61.2 cM mouse T450-p 447857 TAQMITItPPDQDDS Pkinase_C ubiquitination translation, altered 21045808 30 5 1 prevents cotranslational Akt ubiquitination -Ctnnd1 CTNND1 Actin-binding; Adaptor/scaffold; Cell adhesion; G protein regulator, misc.; Motility/polarity/chemotaxis D3ZZZ9 311163 3q24 rat T310-p 450457 GTARRTGtPSDPRRR intracellular localization; activity, inhibited cell motility, induced CDH2(DISRUPTS) 24929360 10 7 28 -BCAR1 P130Cas Adaptor/scaffold; Motility/polarity/chemotaxis P56945 9564 16q23.1 human Y306-p 448779 PSNHHAVyDVPPSVS cell growth, induced 26867768 3 15 191 metastases -H3c1 H3 DNA-binding P68433 360198 13|13 A3.1 mouse K18-ac 465520 TGGKAPRkQLATKAA Histone methylation endocytosis, altered; cell adhesion, altered 17882261; 33195484 57 27 381 axon guidance; K18 enhances methylation at H3R17me2 -Ptpn11 SHP-2 EC 3.1.3.48; Motility/polarity/chemotaxis; PHOSPHATASE; Protein phosphatase, tyrosine (non-receptor) P35235 19247 5|5 F mouse Y63-p 455054 IQNTGDYyDLYGGEK SH2 enzymatic activity, inhibited; phosphorylation cell growth, altered 18827006 1 13 72 -NUTM1 NUTM1 Unknown function Q86Y26 256646 15q14 human S1029-p 13165102 YLLASKLsLSPREHP NUT intracellular localization 17934517 1 0 0 nuclear-cytoplasmic shuttling -Axin1 axin 1 Adaptor/scaffold; Tumor suppressor O70239 79257 10q12 rat S492-p 451104 SPGPGHRsPDSGHVA Axin_b-cat_bind cytoskeletal reorganization 22933777 2 12 6 Phosphorylation regulates responsive to Sema3A induced growth cone collapse. -TSPYL2 TSPYL2 DNA replication; Transcription regulation Q9H2G4 64061 Xp11.22 human S20-p 3212187 RRLSSSEsPQRDPPP cell growth, altered 11395479 1 6 7 -TRAIP TRAIP EC 6.3.2.-; Ligase; Nucleolus; UBIQUITIN LIGASE; Ubiquitin conjugating system; Ubiquitin ligase Q9BWF2 10293 3p21.31 human K205-sm 53529103 AVYCVSLkKEYENLK protein degradation; molecular association, regulation; protein stabilization; ubiquitination; intracellular localization cell cycle regulation 26820530; 30619364 2 0 0 interacts with nsp1-alpha of PRRSV (porcine reproductive and respiratory syndrome virus) K48 ubiquitination and degradation of serine/threonine-protein kinase (TBK1); inhibits ubiquitination -ATXN3 ataxin-3 DEUBIQUITINASE; DNA repair, damage; EC 3.4.19.12; Protease; Transcription regulation; Ubiquitin-specific protease P54252 4287 14q32.12 human K117-ub 10835606 RSFICNYkEHWFTVR Josephin enzymatic activity, induced 25988170 3 12 90 induces deubiquitinase activity of the enzyme -Ezr Ezrin Cytoskeletal; Motility/polarity/chemotaxis P26040 22350 17|17 A1 mouse Y354-p 448105 LMLRLQDyEQKTKRA ERM_helical intracellular localization apoptosis, inhibited; cell growth, altered 18182570; 24385580 14 5 259 -SNAP29 SNAP29 Vesicle O95721 9342 22q11.21 human S105-p 56651951 MDQDLKIsQKHINSI V-SNARE_C intracellular localization; receptor recycling, altered cell adhesion, induced 29454964 1 1 0 focal adhesion structure formation; membrane localization and for membrane fusion dependent processes -PRKDC DNAPK DNA repair, damage; EC 2.7.11.1; KINASE; Kinase, protein; Nucleolus; Protein kinase, Ser/Thr (non-receptor); Protein kinase, atypical P78527 5591 8q11.21 human S2053-p 23099445 STGVQSYsYSSQDPR DNAPKcs_CC3 molecular association, regulation DNA repair, inhibited DNA(INDUCES) 24687855 1 0 2 induces c-NHEJ, restricts end processing -SARS1 SARS Aminoacyl-tRNA synthetase; EC 6.1.1.11; Ligase; RNA processing; Translation; Translation regulation P49591 6301 1p13.3 human K323-ac 11317592 FRVHQFEkIEQFVYS tRNA-synt_2b intracellular localization carcinogenesis, inhibited; cell growth, inhibited 34400610 1 2 0 nuclear translocation, enhances adipose deposition in mice, inhibits progression of breast cancer, and the growth of breast cancer xenografts in mice -HSPA5 GRP78 Chaperone; Heat shock protein; KINASE P11021 3309 9q33.3 human K585-ac 466070 DKEKLGGkLSSEDKE HSP70 molecular association, regulation PERK(DISRUPTS) 20072656 1 2 5 participates verinostat-induced cytotoxicity leading to its antitumor activity -KLRF1 KLRF1 Membrane protein, integral; Receptor, misc. Q9NZS2 51348 12p13.31 human Y7-p 17831300 _MQDEERyMTLNVQS molecular association, regulation Syk(INDUCES); Lck(INDUCES); ZAP70(INDUCES) 21149606 1 0 0 required for KLRF1-mediated cytotoxicity -ZNF322 ZNF322A C2H2-type zinc finger protein; Transcription factor Q6U7Q0 79692 6p22.2 human T150-p 1869121002 LVHQRSHtGEKPYLC activity, induced; molecular association, regulation carcinogenesis, induced; chromatin organization, altered; cell motility, induced; cell growth, induced; transcription, induced DNA(INDUCES) 31399647 1 1 0 chromatin binding; increases recruitment to ADD1 and CCND1 promoters -BATF BATF DNA-binding; Transcription factor Q16520 10538 14q24.3 human S43-p 450321 NRIAAQKsRQRQTQK bZIP_1 transcription, inhibited 12809553 1 0 0 -CYP3A4 CYP3A4 Cell surface; Cofactor and Vitamin Metabolism - retinol; EC 1.14.14.1; Lipid Metabolism - linoleic acid; Membrane protein, integral; Oxidoreductase; Xenobiotic Metabolism - drug metabolism - cytochrome P450; Xenobiotic Metabolism - drug metabolism - other enzymes; Xenobiotic Metabolism - metabolism by cytochrome P450 P08684 1576 7q22.1 human S420-p 5938007 KFLPERFsKKNKDNI p450 protein degradation; ubiquitination 19095658; 22101235; 25451919 3 2 0 -PCBP2 hnRNP E2 RNA splicing; RNA-binding Q15366 5094 12q13.13 human S173-p 482916 MLETLSQsPPKGVTI protein stabilization; molecular association, regulation cell differentiation, inhibited; translation, inhibited RNA(INDUCES) 17475908 1 19 2 -FBXW5 FBXW5 UBIQUITIN LIGASE; Ubiquitin conjugating system; Ubiquitin ligase Q969U6 54461 9q34.3 human S151-p 20831310 SQFNKDDsLLLASGV protein degradation; ubiquitination cell cycle regulation 21725316 1 0 0 Induces degradation of HsSAS-6 and inhibits its ubiquitination. Induces centrosome duplication -PRKCA PKCA EC 2.7.11.13; KINASE; Kinase, protein; Oncoprotein; Protein kinase, AGC; Protein kinase, Ser/Thr (non-receptor) P04409 282001 cow T495-p 449890 HMMDGVTtRTFCGTP Pkinase enzymatic activity, induced 8349635 2 1 11 -Rgs14 RGS14 GAP; GAP, RGS O08773 114705 17p14 rat S218-p 4713256 PKLKPGKsLPLGVEE molecular association, regulation 14-3-3 gamma(INDUCES); G-alpha i1(DISRUPTS) 30093406 1 18 1 Protein 14-3-3- gamma decreased binding G-alpha-i1:AlF binding with RGS14 in RGS domain -E2F6 E2F6 DNA-binding; Transcription factor O75461 1876 2p25.1 human S12-p 27532759 RPARKLPsLLLDPTE molecular association, regulation transcription, induced DNA(DISRUPTS) 23954429 1 5 0 response to DNA replication stress -Hsf1 HSF1 DNA-binding; Transcription factor P38532 15499 15 D3|15 35.95 cM mouse S230-p 448072 PKYGRQYsLEHVHGP transcription, induced 23055521 16 2 4 -SNRPB snRNP B1 RNA processing; RNA splicing; RNA-binding; Spliceosome P14678 6628 20p13 human R172-m2 476757 PTQYPPGrGGPPPPM molecular association, regulation SMN(INDUCES) 11720283 1 1 4 -Ncl NCL DNA-binding; Helicase; Nuclear receptor co-regulator; Nucleolus; RNA-binding P09405 17975 1 C5|1 43.94 cM mouse S40-p 468243 MSEDEDDsSGEEEVV molecular association, regulation carcinogenesis, induced; cell growth, induced; transcription, induced RNA(INDUCES) 37039106 1 18 2 -Fbp1 FBPase Carbohydrate Metabolism - fructose and mannose; Carbohydrate Metabolism - glycolysis and gluconeogenesis; Carbohydrate Metabolism - pentose phosphate pathway; EC 3.1.3.11; Mitochondrial; Phosphatase (non-protein) Q9QXD6 14121 13|13 B3 mouse S144-p 15501075 FGIYRKKsTDEPSEK FBPase molecular association, regulation carcinogenesis, induced; cell motility, induced; cell growth, induced; transcription, induced; signaling pathway regulation CHIP(DISRUPTS); NFkB-p65(DISRUPTS) 32754266 1 4 3 induces NFKB binding to DNA, regulates NFKB pathway -NR0B2 NR0B2 Nuclear receptor; Nuclear receptor co-regulator; Transcription, coactivator/corepressor Q15466 8431 1p36.11 human T55-p 28702400 QLCAPHRtCREALDV Hormone_recep molecular association, regulation; methylation; intracellular localization chromatin organization, altered; transcription, inhibited; signaling pathway regulation HNF4 alpha(INDUCES); PGC-1 alpha(INDUCES); PRMT5(INDUCES); NR5A2(NOT_REPORTED); BRME1(INDUCES) DNA(INDUCES) 23824184 4 0 0 increases methylation NR0B2 at R57 -Irs1 IRS1 Adaptor/scaffold; Motility/polarity/chemotaxis P35570 25467 9q34 rat Y608-p 447555 NLHTDDGyMPMSPGV molecular association, regulation PIK3R1(INDUCES) 7504175; 7588273 33 12 294 -Polr2a POLR2A EC 2.7.7.48; EC 2.7.7.6; Nucleotide Metabolism - purine; Nucleotide Metabolism - pyrimidine; Transcription initiation complex; Transferase P08775 20020 11 B3|11 42.86 cM mouse K1922-ub 2134719 TYSPTSPkYSPTSPT RNA_pol_Rpb1_R protein degradation 17526739 1 1 0 -MVD MVD EC 4.1.1.33; Lyase; Secondary Metabolites Metabolism - terpenoid backbone biosynthesis P53602 4597 16q24.2 human S96-p 476192 LARKRRNsRDGDPLP activity, induced apoptosis, inhibited 25378391 1 21 8 Rac1 activation/geranylgeranylation, disruption of the mevalonate pathway induces macrophage apoptosis. -SORBS2 ArgBP2 Adaptor/scaffold; Motility/polarity/chemotaxis O94875 8470 4q35.1 human S259-p 467482 DFRKRRKsEPAVGPP molecular association, regulation; intracellular localization cytoskeletal reorganization 14-3-3 zeta(INDUCES); ACTN1(DISRUPTS) 25429109 1 38 24 ArgBP2 is down-regulated in some aggressively metastatic cancers -AHR AHR DNA-binding; Transcription factor P35869 196 7p21.1 human S68-p 451013 INKLDKLsVLRLSVS HLH intracellular localization 14985336 1 0 0 -MPL MPL Membrane protein, integral; Receptor, cytokine P40238 4352 1p34.2 human K573-ub 11956705 SLLEILPkSSERTPL protein degradation cell growth, inhibited 19880496 1 0 0 -FH fumarase Carbohydrate Metabolism - citrate (TCA) cycle; EC 4.2.1.2; Lyase; Mitochondrial; Tumor suppressor P07954 2271 1q43 human S46-p 36132325 PNAARMAsQNSFRIE molecular association, regulation; intracellular localization carcinogenesis, induced; cell growth, induced; signaling pathway regulation RBPJ(DISRUPTS); 14-3-3 zeta(INDUCES) 30683654 1 5 0 -Csnk1g2 CK1G2 EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, CK1; Protein kinase, Ser/Thr (non-receptor) Q8BVP5 103236 10|10 C1 mouse S211-p 1871246000 IPYREHKsLTGTARY Pkinase molecular association, regulation; phosphorylation RIPK3(INDUCES) 33206046 1 1 0 inhibits phosphorylation of MLKL, binding to RIPK3 inhibits RIPK3 binding to RIPK1 -Megf10 MEGF10 Membrane protein, integral Q6DIB5 70417 18|18 D3 mouse Y1061-p 478426 PARRDSPyAEINNST cell cycle regulation; cell motility, altered 18515860 1 3 7 -APH1A APH1A Apoptosis; Endoplasmic reticulum; Membrane protein, integral; Membrane protein, multi-pass Q96BI3 51107 1q21.2 human S257-p 15229310 DSRVMVYsALRIPPE molecular association, regulation; enzymatic activity, altered ARRB2(INDUCES) 35858570 1 5 16 -Wwtr1 TAZ Oncoprotein; Transcription, coactivator/corepressor Q9EPK5 97064 3|3 D mouse Y316-p 27138200 SGLGLGCySVPTTPE molecular association, regulation; intracellular localization cell growth, induced; transcription, induced; transcription, inhibited TAZ(INDUCES) 23045390; 28939028 3 0 0 nuclear localization; Y316 TAZ negatively regulates SL6A12 and SLC5A3 gene expression; luciferase reporter -PITPNM1 PITPNM1 Cell surface O00562 9600 11q13.2 human T59-p 3597300 PGGSGQYtHKVYHVG IP_trans intracellular localization 12225667 1 0 0 -Pcyt1a PCYT1A EC 2.7.7.15; Lipid Metabolism - glycerophospholipid; Transferase P19836 140544 11q22 rat S315-p 451321 GRMLQAIsPKQSPSS enzymatic activity, inhibited 15788406 4 67 13 -Mybl2 B-Myb DNA-binding; Motility/polarity/chemotaxis; Transcription factor P48972 17865 2 H2|2 84.0 cM mouse T497-p 450109 TPLHRDKtPLHQKYP Cmyb_C activity, induced 9840932 4 0 12 -Mpl MPL Membrane protein, integral; Receptor, cytokine Q08351 17480 4 D2.1|4 54.61 cM mouse S565-p 3091404 LLEILPKsSESTPLP activity, induced; phosphorylation cell growth, altered 10918061 1 0 0 tyrosine phosphorylation of JAK2 -TIGIT TIGIT Cell surface; Membrane protein, integral Q495A1 201633 3q13.31 human Y225-p 27266400 DCAELHDyFNVLSYR molecular association, regulation signaling pathway regulation GRB2(INDUCES); SHIP(INDUCES) 23154388 2 0 0 Grb2 enhances SHIP1 binding to TIGIT; inhibits NK cell activity by suppressing PI3K and MAPK signaling -Grb10 GRB10 Adaptor/scaffold Q60760 14783 11 A1|11 7.15 cM mouse S503-p 455870 MNILSSQsPLHPSTL molecular association, regulation; protein stabilization cell growth, inhibited; transcription, induced; signaling pathway regulation INSR(DISRUPTS); Raptor(INDUCES) 21659605; 24746805; 26000738 7 16 17 reduced soft agar colony formation ; thermogenic and lipolytic gene expression induced -Ppp1r12a MYPT1 Motility/polarity/chemotaxis; PHOSPHATASE; Protein phosphatase, regulatory subunit Q10728 116670 7q21 rat T697-p 448587 ARQSRRStQGVTLTD enzymatic activity, inhibited; activity, inhibited; phosphorylation 12359219; 19095646; 33972751 66 42 226 inhibits MLCP activity -Klf4 KLF4 C2H2-type zinc finger protein; DNA-binding; Transcription factor Q923V7 114505 5q24 rat K224-ac 1880848202 PGGGLMGkFVLKASL transcription, induced 35046941 2 0 0 IL-6 transcription -LYN LYN EC 2.7.10.2; KINASE; Kinase, protein; Oncoprotein; Protein kinase, TK; Protein kinase, tyrosine (non-receptor) P07948 4067 8q12.1 human Y32-p 454717 RNTERTIyVRDPTSN phosphorylation carcinogenesis, induced; cell growth, induced 23764002 1 12 105 induces phosphorylation at Y397 MCM7 phosphorylation -IL6ST gp130 Membrane protein, integral; Receptor, cytokine P40189 3572 5q11.2 human Y759-p 448181 NTSSTVQySTVVHSG activity, induced; molecular association, regulation; activity, inhibited; phosphorylation cell differentiation, altered; signaling pathway regulation; transcription, altered SOCS3(INDUCES); SHP-2(INDUCES) 10661409; 10764798; 10777583; 10800945; 10829066; 10946280; 16459330; 25078695; 9632795 14 1 2 induces ERK phosphorylation and signaling; Mutation of gp130 Y759F removes transcriptional inhibition (through removing SOCS3 binding site). SOCS3's effect through OSMR is tyrosine phosphorylation-independent. -ATP1A1 ATP1A1 EC 3.6.3.9; Hydrolase; Membrane protein, integral; Membrane protein, multi-pass; Transporter; Transporter, ion channel P05023 476 1p13.1 human Y260-p 454981 TARGIVVyTGDRTVM E1-E2_ATPase molecular association, regulation; phosphorylation carcinogenesis, inhibited; transcription, inhibited; signaling pathway regulation Src(INDUCES) 30120256 2 44 1345 regulates phosphorylation of ERK, Src, Akt, EGFR, controls aerobic glycolysis -Pea15 PEA-15 Apoptosis; Motility/polarity/chemotaxis Q9Z297 100736554 hamster S104-p 455750 TKLTRIPsAKKYKDI molecular association, regulation ERK1(DISRUPTS); ERK2(DISRUPTS) 15916534 13 27 322 -PTK2B Pyk2 EC 2.7.10.2; KINASE; Kinase, protein; Nuclear receptor co-regulator; Protein kinase, TK; Protein kinase, tyrosine (non-receptor) Q14289 2185 8p21.2 human S778-p 2192705 HNVFKRHsMREEDFI intracellular localization 22802128 1 10 2 -Traf6 TRAF6 EC 6.3.2.-; Ligase; UBIQUITIN LIGASE; Ubiquitin conjugating system; Ubiquitin ligase P70196 22034 2|2 E2 mouse S46-p 1040254704 SASTGNLsSSFMEEI ubiquitination 29563609 1 0 0 colon epithelia in?ammation -CXADR CXADR Cell adhesion; Membrane protein, integral; Receptor, misc. P78310 1525 21q21.1 human S293-p 3193535 SRTSTARsYIGSNHS molecular association, regulation; intracellular localization KIF22(INDUCES) 29382784 1 5 2 translocation within cell junctions in response to EGF -KCNJ2 KCNJ2 Channel, potassium; Membrane protein, integral; Membrane protein, multi-pass P63252 3759 17q24.3 human Y242-p 2097300 RITSEGEyIPLDQID IRK_C activity, induced; activity, inhibited cell differentiation, altered 18216177; 21570948 3 0 0 inactivates KCNJ2 current -Marcksl1 MLP Cell cycle regulation P28667 17357 4 D2.2|4 63.26 cM mouse T148-p 454299 QEGKAAAtPESQEPQ MARCKS protein conformation cytoskeletal reorganization; cell motility, inhibited 22751924 1 44 53 Increases actin stability and regulation of dendritic filopodium generation in neurons -GJA1 GJA1 Channel, misc.; Membrane protein, integral; Membrane protein, multi-pass; Motility/polarity/chemotaxis P17302 2697 6q22.31 human S282-p 448854 TAPLSPMsPPGYKLV protein degradation; protein stabilization; molecular association, regulation; ubiquitination; intracellular localization; activity, inhibited; protein conformation endocytosis, induced; carcinogenesis, inhibited; apoptosis, induced; cytoskeletal reorganization; signaling pathway regulation CLTA(INDUCES) 15958277; 18047584; 23828237; 24399133; 24492000; 24742583; 26033246; 33255329 42 7 1 gap junction regulation; inhibits pregnancy-adapted Ca2+ response -TH TH Amino Acid Metabolism - tyrosine; EC 1.14.16.2; Endoplasmic reticulum; Mitochondrial; Oxidoreductase; Vesicle P07101 7054 11p15.5 human S71-p 448545 RFIGRRQsLIEDARK TOH_N enzymatic activity, induced 7901013 62 11 11 -ENG ENG Membrane protein, integral; Motility/polarity/chemotaxis; Receptor, misc. P17813 2022 9q34.11 human Y614-p 34729907 TAALWYIySHTRSPS receptor internalization, induced; protein degradation; intracellular localization cell motility, induced; cell growth, induced 25070888 1 0 0 1)ALK1, TBRII, ENG degradation 2) induces endothelial capillary sprouting and stability, EC functions during angiogenesis -Sln sarcolipin Endoplasmic reticulum; Membrane protein, integral Q6SLE7 rat T5-p 459214 ___MERStQELFINF Sarcolipin activity, induced 19631655 6 0 0 regulates myocyte calcium transient and contractility -Cldn4 Claudin-4 Cytoskeletal; Membrane protein, integral; Membrane protein, multi-pass Q5XIT8 304407 rat S199-p 15425616 KPYSAKYsAARSVPA molecular association, regulation; intracellular localization occludin(INDUCES) 25503106 1 1 2 increased paracellular peremability and saliva secretion, crucial component of tight juction barrier -MFN2 MFN2 Cell cycle regulation; Cytoskeletal; EC 3.6.5.-; Hydrolase; Membrane protein, integral; Membrane protein, multi-pass; Mitochondrial O95140 9927 1p36.22 human T111-p 17402150 RTSNGKStVINAMLW Dynamin_N intracellular localization autophagy, induced 35646911 3 1 0 regulates Parkin recruitmeent to mitochondria; miophagy -NOP53 GLTSCR2 Nucleolus Q9NZM5 29997 19q13.33 human T289-p 60120300 PATEQAAtQESTFQE Nop53 protein degradation; molecular association, regulation; intracellular localization apoptosis, induced RPL11(DISRUPTS) 27829214 1 0 0 -Cryab CRYAB Chaperone; Heat shock protein P23927 12955 9 A5.3|9 27.75 cM mouse S59-p 448783 PSFLRAPsWIDTGLS protein degradation; molecular association, regulation; intracellular localization apoptosis, inhibited; cytoskeletal reorganization; signaling pathway regulation 10816593; 16979163; 19252088; 28196893; 29088822 46 22 0 stabilizes actin filaments; phosphorylation of this site stimulates interaction with multiple proteins and activates multiple pathways; induces reactive astrogliosis -VPS13D VPS13D Vesicle Q5THJ4 55187 1p36.22-p36.21 human T770-p 1872786900 FSDDEYKtPLATPPN VPS13_mid_rpt molecular association, regulation; intracellular localization VAPB(INDUCES) 33891013 1 0 0 -CCNB1 CCNB1 Activator; Cell cycle regulation P14635 891 5q13.2 human S128-p 448815 LVDTASPsPMETSGC intracellular localization DNA(INDUCES) 20117088; 22726437 5 1 0 enhances nuclear import -MEF2C MEF2C DNA-binding; Transcription factor Q06413 4208 5q14.3 human T80-p 19083402 NEPHESRtNSDIVET molecular association, regulation cell differentiation, induced p300(INDUCES) 21556048 1 1 0 skeletal, but not cardiac, myogenesis, induces recruitment of p300 to muscle-specific promoters for histone acetylation -Tnni3 TNNI3 Actin-binding; Motility/polarity/chemotaxis; Motor P23693 29248 1q12 rat S24-p 448424 APVRRRSsANYRAYA Troponin-I_N protein conformation; activity, inhibited cell motility, altered; cytoskeletal reorganization 16236710; 16936010; 18550549; 28587770 64 12 16 heart contractility and relaxation; regulates cardiac contractile function -UBA52-RPS27A-UBB-UBC ubiquitin Ubiquitin-like modifier P62991 mouse K11-ub 486301 FVKTLTGkTITLEVE ubiquitin protein degradation; molecular association, regulation GDI1(DISRUPTS) 33976225; 35343654 25 22 155 Promotes the Post-Golgi Tra?cking of TLR4 and TLR9; inhibit the post-ER tra?cking of TLRs; forms an electrostatic interaction with D129, loss of K133 ubiquitylation or the K133:D129 salt bridge stabilizes IL-1B -CEACAM1 CEACAM1 Cell adhesion; Immunoglobulin superfamily; Membrane protein, integral; Motility/polarity/chemotaxis P13688 634 19q13.2 human S494-p 473039 KMNEVTYsTLNFEAQ apoptosis, altered; cytoskeletal reorganization 17192268 1 0 0 plays a role in cell polarization and lumen formation -NPM1 NPM1 Nucleolus; Oncoprotein; RNA-binding; Translation P06748 4869 5q35.1 human S48-p 14577038 QLSLRTVsLGAGAKD Nucleoplasmin protein degradation; molecular association, regulation; intracellular localization; enzymatic activity, inhibited; protein conformation signaling pathway regulation NPM1(NOT_REPORTED) 25071014 2 3 0 regulates NPM1 oligomerization; induces cellular resistance to IR; inhibits MDM2 activity; induces p53 stability; regulates ARF localization and stability -KHSRP KHSRP RNA-binding Q92945 8570 19p13.3 human S193-p 473552 GLPERSVsLTGAPES KH_1 molecular association, regulation; intracellular localization; protein conformation transcription, altered 14-3-3 sigma(INDUCES); 14-3-3 zeta(INDUCES) 17177604; 19198587 2 10 7 controls beta-catenin gene expression by controlling its mRNA stability; phosphorylation of this site inhibits interaction with the exosome -ARHGEF7 ARHGEF7 iso1 GEF; GEF, Rac/Rho; Motility/polarity/chemotaxis Q14155-1 8874 13q34 human T526-p 455216 EFASRKStAALEEDA RhoGEF67_u2 activity, induced; molecular association, regulation cell motility, altered; cytoskeletal reorganization ARHGAP13(DISRUPTS) 14557270; 25150978 7 6 1 -RAD17 RAD17 Cell cycle regulation O75943 5884 5q13.2 human S656-p 447756 SASELPAsQPQPFSA protein stabilization; molecular association, regulation; phosphorylation cell cycle regulation; cell growth, altered RAD1(INDUCES); claspin(INDUCES) 11418864; 11687627; 16885023; 24876101; 26960975 13 0 0 -LIFR LIFR Membrane protein, integral; Receptor, cytokine P42702 3977 5p13.1 human K620-ac 1883810405 VGSSPPSkIASMEIP molecular association, regulation; phosphorylation carcinogenesis, induced; cell growth, induced LIFR(INDUCES) 35172032 1 1 0 necessary for homodimerization and subsequent S1044 phosphorylation, and consequent AKT activation, and PCa progression, promoted the growth and metastasis of PCa cells -ZFPM1 FOG1 C2H2-type zinc finger protein; Transcription regulation Q8IX07 161882 16q24.2 human K501-sm 14988611 SPAPARVkAELSSPT molecular association, regulation CTBP1(INDUCES) 20587419 1 0 0 -VIM Vimentin Cytoskeletal; Motility/polarity/chemotaxis P08670 7431 10p13 human S339-p 14582709 ALKGTNEsLERQMRE Filament molecular association, regulation; intracellular localization carcinogenesis, induced; cell motility, induced; cell growth, induced; transcription, induced SMAD2(INDUCES); SMAD3(INDUCES) 33963314 1 20 0 -Pld1 PLD1 iso2 EC 3.1.4.4; Lipid Metabolism - ether lipid; Lipid Metabolism - glycerophospholipid; Motility/polarity/chemotaxis; Phospholipase P70496-2 25096 2q24 rat T147-p 448573 PIPTKRHtFRRQNVK PX enzymatic activity, induced 10441128; 10788479 5 0 0 -Ncoa3 SRC-3 ACETYLTRANSFERASE; Acetyltransferase; EC 2.3.1.48; Motility/polarity/chemotaxis; Nuclear receptor co-regulator; Transcription, coactivator/corepressor O09000 17979 2|2 H3 mouse R1184-m2 2363403 LRMQLQQrLQGQQFL protein degradation transcription, inhibited CBP(INDUCES) 17043108 1 1 21 -TIAM1 TIAM1 GEF; GEF, Rac/Rho; Motility/polarity/chemotaxis; Oncoprotein Q13009 7074 21q22.11 human S1466-p 4727743 SDAVSASsPEKESQQ phosphorylation cell cycle regulation 26078008 1 8 0 induces phosphorylation and centrosomal activation of PAK1/2 in mitosis; regulates centrosome separation -Tab2 TAB2 Adaptor/scaffold Q99K90 68652 10|10 A1 mouse K329-sm 31089526 RKNQIEIkLEPPQRN molecular association, regulation transcription, inhibited; signaling pathway regulation 33184450 2 0 0 inhibition of TRAF6/TAB2/TAK1 complex and downstream MAPK and NF-?B pathway -H4C1 H4 DNA-binding P62805 8359 6p22.2 human K16-ac 458960 GLGKGGAkRHRKVLR protein stabilization; acetylation; molecular association, regulation; intracellular localization; methylation cell cycle regulation; carcinogenesis, induced; carcinogenesis, inhibited; cell growth, inhibited; apoptosis, induced; transcription, induced; signaling pathway regulation; transcription, altered; DNA repair, induced; chromatin organization, altered; cell growth, induced; cell differentiation, induced; DNA repair, altered; cytoskeletal reorganization TBN(INDUCES); polybromo 1(INDUCES); 14-3-3 zeta(INDUCES); 14-3-3 epsilon(INDUCES); CGI-09(INDUCES); 53BP1(DISRUPTS); MYST1(INDUCES); BRD4(INDUCES); BRDT(INDUCES); BRD7(INDUCES); H2AZ(INDUCES); BRD4(NOT_REPORTED); H2AFV(INDUCES); PUS1(INDUCES); THOC4(INDUCES); TAF4(INDUCES) DNA(DISRUPTS) 12208845; 15456746; 16227571; 16469925; 16648462; 17498659; 17530637; 18179771; 18628788; 18701507; 19766566; 19828451; 19854137; 19917601; 20003410; 20043883; 20118981; 20368734; 20439491; 20479123; 20547755; 20657587; 20720004; 21047799; 21726812; 23287868; 23318425; 23329852; 23394073; 23970329; 31071955; 31794431; 31881804; 35409160 106 26 531 expression of genes in clusters 8 and 9 by cooperating with H4K16ac, H3K4me2, and H3K4me3 at the transcription start sites (TSSs); HDACi panobinostat induced apoptosis in K562 and K562-IR cells -SERPINF1 PEDF Inhibitor; Secreted; Secreted, signal peptide P36955 5176 17p13.3 human S24-p 455231 SSCQNPAsPPEEGSP molecular association, regulation apoptosis, altered; carcinogenesis, altered; cell motility, altered LEPR(INDUCES) 21059648 2 0 0 -SNAI1 Snail1 C2H2-type zinc finger protein; Transcription factor O95863 6615 20q13.13 human S115-p 6097707 PAPSSFSsTSVSSLE intracellular localization cell motility, altered; transcription, altered 15448698; 19004823 2 0 0 Localization mediated by S107, S111, S115 and S119. -NOS2 iNOS Amino Acid Metabolism - arginine and proline; EC 1.14.13.39; Oxidoreductase P35228 4843 17q11.2 human S745-p 763800 KSRQNLQsPTSSRAT FAD_binding_1 enzymatic activity, induced 17804409 1 1 0 -Slc12a5 KCC2 iso2 Membrane protein, integral; Membrane protein, multi-pass; Transporter; Transporter, SLC family Q63633-2 171373 3q42 rat T1007-p 10045602 DPEKVHLtWTKDKSA SLC12 activity, inhibited 24849604; 26126716 9 5 1 -CASP8 CASP8 iso9 Apoptosis; EC 3.4.22.61; Protease Q14790-9 841 2q33.1 human K215-ub 40190202 RVILGEGkLDILKRV DED carcinogenesis, induced; apoptosis, inhibited 24287696 1 2 0 -FOXN2 FOXN2 DNA-binding P32314 3344 2p16.3 human S365-p 799824601 EDDPLGDsGYASQPC protein degradation; ubiquitination BTRC(INDUCES) 29396548 1 0 0 -AGTR1 AT1 GPCR, family 1; Membrane protein, integral; Membrane protein, multi-pass; Receptor, GPCR P30556 185 3q24 human Y319-p 448745 YFLQLLKyIPPKAKS molecular association, regulation PLCG1(INDUCES) 9516477 5 0 0 -STAT3 STAT3 DNA-binding; Motility/polarity/chemotaxis; Nuclear receptor co-regulator; Transcription factor P40763 6774 17q21.2 human Y640-p 386186603 QIQSVEPyTKQQLNN SH2 molecular association, regulation; protein conformation; phosphorylation carcinogenesis, inhibited; cell growth, inhibited; apoptosis, induced; transcription, induced; transcription, altered; transcription, inhibited DNA(DISRUPTS) 29162862; 30910759; 32231398; 34818414; 36630607 5 0 0 inhibits phosphorylation at Y705; STAT3 hyper activity decrease cell death; inhibits phosphorylation of other sites; inhibits phosphorylation; Y640E mutant showed strongly impaired LIF-dependent reporter transcription, comparable to the Y705F mutant -H3c1 H3 DNA-binding P68433 360198 13|13 A3.1 mouse S57-p 481136 EIRRYQKsTELLIRK Histone molecular association, regulation chromatin organization, altered; transcription, inhibited DNA(DISRUPTS) 26199864 2 19 9 -Atf1 ATF-1 Transcription factor P81269 11908 15|15 F1 mouse S36-p 465558 VHQVSSLsESEESQD molecular association, regulation cell growth, induced; transcription, induced HSF1(INDUCES) 25312646 4 1 0 HSP70 expression, increases cell survival -UHRF1 UHRF1 iso2 DNA-binding; EC 6.3.2.-; EC 6.3.2.19; Ligase; Transcription factor; UBIQUITIN LIGASE; Ubiquitin conjugating system; Ubiquitin ligase Q96T88-2 29128 19p13.3 human S674-p 469962 GGPSRAGsPRRTSKK molecular association, regulation; ubiquitination BRCA1(INDUCES) 26727879 3 12 0 accumulation at DSB sites -Ptgir PTGIR GPCR, family 1; Membrane protein, integral; Membrane protein, multi-pass; Receptor, GPCR P43252 19222 7 A2|7 9.15 cM mouse S355-p 450985 APLSRPAsGRRDPPA molecular association, regulation G-alpha(q)(INDUCES); G-alpha i2(INDUCES) 11443126 3 0 0 -MAPK8IP1 JIP1 Adaptor/scaffold Q9UQF2 9479 11p11.2 human T103-p 449924 LIDATGDtPGAEDDE molecular association, regulation DLK(DISRUPTS) 12756254 2 1 1 -POU2F1 Oct1 DNA-binding; Transcription factor P14859 5451 1q24.2 human S385-p 456220 RRRKKRTsIETNIRV Homeodomain molecular association, regulation; activity, inhibited DNA(DISRUPTS) 1684878 1 14 0 -KDM1A LSD1 DEMETHYLASE; Demethylase; EC 1.-.-.-; Nuclear receptor co-regulator; Oxidoreductase; Transcription factor O60341 23028 1p36.12 human K322-m3 41692103 GRVATFRkGNYVADL Amino_oxidase protein stabilization; molecular association, regulation cell growth, induced; transcription, altered RCOR1(INDUCES) 26183527 1 1 0 lower CDKN1A expression and higher SOX2 expression -CD44 CD44 Cell adhesion; Membrane protein, integral; Motility/polarity/chemotaxis; Receptor, misc. P16070 960 11p13 human S704-p 465561 SGLNGEAsKSQEMVH molecular association, regulation; intracellular localization cell motility, altered MMP9(DISRUPTS) 1281449; 19582779 3 10 10 -GFAP GFAP Cytoskeletal F1RR02 396562 pig S13-p 449619 VTSAARRsYVSSLET Filament_head neural plasticity; cell cycle regulation; cytoskeletal reorganization 1379174; 22528834 11 5 0 -Foxo1 FOXO1A DNA-binding; Nuclear receptor co-regulator; Oncoprotein; Transcription factor Q9R1E0 56458 3 C|3 23.19 cM mouse S246-p 471071 EGGKSGKsPRRRAAS molecular association, regulation; intracellular localization apoptosis, induced; apoptosis, inhibited; transcription, induced; transcription, inhibited DUSP6(INDUCES) 22503562; 22848439; 25673854; 32075913 13 2 2 -Pdgfrb PDGFRB EC 2.7.10.1; KINASE; Kinase, protein; Membrane protein, integral; Oncoprotein; Protein kinase, TK; Protein kinase, tyrosine (receptor) P05622 18596 18 E1|18 34.41 cM mouse Y1008-p 447522 LDTSSVLyTAVQPNE molecular association, regulation; enzymatic activity, induced; phosphorylation cell growth, inhibited; cell differentiation, induced; signaling pathway regulation SHP-2(INDUCES) 11940581; 17018529; 31914388 17 0 0 MEK/ERK1/1 pathway -ULK1 ULK1 Autophagy; EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, Other; Protein kinase, Ser/Thr (non-receptor) O75385 8408 12q24.33 human S556-p 3176155 GLGCRLHsAPNLSDL phosphorylation; enzymatic activity, induced cell cycle regulation; carcinogenesis, induced; cell growth, inhibited; apoptosis, induced; transcription, induced; autophagy, induced; cell growth, induced; apoptosis, inhibited 27864418; 33531625; 34224814; 34421918; 34654847; 34759263; 35316314; 35368866; 35670018; 35740063; 35977966; 36799863; 36927870 61 26 48 induces mitophagy -ACO2 ACO2 Carbohydrate Metabolism - citrate (TCA) cycle; Carbohydrate Metabolism - glyoxylate and dicarboxylate; EC 4.2.1.3; Lyase; Mitochondrial Q99798 50 22q13.2 human K258-ac 1875261900 VAGILTVkGGTGAIV Aconitase enzymatic activity, induced transcription, inhibited 33115805 1 1 0 K258 acetylation of ACO2 is important for its optimal enzyme activity and function in prostate cancer cells: AR and its coregulator SRC-2 repress SIRT3 expression and maintain high levels of acetylated K258. -STAT1 STAT1 DNA-binding; Transcription factor P42224 6772 2q32.2 human K703-sm 3278913 PKGTGYIkTELISVS molecular association, regulation; phosphorylation transcription, inhibited DNA(DISRUPTS) 12855578; 15761017; 17277783; 19174562; 23043228 9 3 0 selective transcription of IFN-gamma mediated genes -Irgm1 IRGM EC 3.6.5.-; Endoplasmic reticulum; Hydrolase Q60766 15944 11|11 B1.2 mouse K398-ub 27194825 DTKNILEkILRDSIF IIGP protein degradation 35197566 1 2 0 -UBTF UBF DNA-binding; Nucleolus; Transcription factor P17480 7343 17q21.31 human K254-m3 31094521 HKALEQRkEYEEIMR HMG_box molecular association, regulation chromatin organization, altered; transcription, inhibited 24234436 1 1 0 -NR1H2 LXR-beta Nuclear receptor P55055 7376 19q13.33 human S426-p 18502600 RMLMKLVsLRTLSSV Hormone_recep molecular association, regulation transcription, induced coronin 2A(DISRUPTS); SENP3(INDUCES) 21331046 1 0 1 -RELA NFkB-p65 DNA-binding; Nuclear receptor co-regulator; Transcription factor Q04206 5970 11q13.1 human K314-m1 7493900 ETFKSIMkKSPFSGP protein degradation transcription, inhibited 19262565 2 1 0 -SHC3 SHC3 Adaptor/scaffold; Motility/polarity/chemotaxis Q92529 53358 9q22.1 human Y424-p 451259 PTGEAPTyVNTQQIP apoptosis, inhibited 12242309 3 0 1 -NEDD1 NEDD1 Cell cycle regulation Q8NHV4 121441 12q23.1 human T550-p 6225645 PPINGSStPNPKIAS molecular association, regulation; phosphorylation cell cycle regulation PLK1(INDUCES) 19509060; 21690413 3 2 6 -PLD2 PLD2 EC 3.1.4.4; Lipid Metabolism - ether lipid; Lipid Metabolism - glycerophospholipid; Motility/polarity/chemotaxis; Phospholipase O14939 5338 17p13.2 human Y169-p 458806 KQKYLENyLNRLLTM PX molecular association, regulation; enzymatic activity, induced cell motility, altered; cell growth, altered GRB2(INDUCES) 16407827; 20647543 2 0 0 -Slc12a3 NCCT Membrane protein, integral; Membrane protein, multi-pass; Transporter; Transporter, SLC family P59158 20497 8 C5|8 46.46 cM mouse T53-p 469616 GSTLYMRtFGYNTID AA_permease_N activity, induced; ubiquitination 22846565; 25472608 25 3 0 -IFNGR1 IFNGR1 Membrane protein, integral; Receptor, cytokine P15260 3459 6q23.3 human Y457-p 451253 KAPTSFGyDKPHVLV molecular association, regulation cell cycle regulation; transcription, altered STAT1(INDUCES) 11390994; 8156998 4 4 34 Induced with serum and IFN-gamma -Npr2 ANPB EC 4.6.1.2; Guanylyl cyclase; KINASE; Kinase, protein; Lyase; Membrane protein, integral; Nucleotide Metabolism - purine; Protein kinase, RGC; Protein kinase, dual-specificity (receptor); Receptor, misc. P16067 116564 5q22 rat S526-p 450024 LRGSSYGsLMTAHGK PK_Tyr_Ser-Thr activity, induced 9624142 2 4 0 -DGCR8 DGCR8 Nucleolus; RNA processing; RNA-binding Q8WYQ5 54487 22q11.21 human Y267-p 479394 KRRTEEKyGGDSDHP molecular association, regulation; protein stabilization RNA(DISRUPTS) 24239349; 26126715 1 11 3 stimulates pri-miR-34c processing -Hmgb1 HMGB1 DNA repair, damage; Nuclear receptor co-regulator P63159 25459 19q12 rat K3-ac 459196 _____MGkGDPKKPR intracellular localization; phosphorylation 19166815; 21257610; 22740141 8 1 0 acetylated residues inhibit it's phosphorylation; induces phosphorylation at S181; inhibits phosphorylation -CSNK1D CK1D EC 2.7.11.1; EC 2.7.11.26; KINASE; Kinase, protein; Protein kinase, CK1; Protein kinase, Ser/Thr (non-receptor) P48730 1453 17q25.3 human T176-p 1868926302 ENKNLTGtARYASIN Pkinase enzymatic activity, induced 31096047 1 1 0 -Frs2 FRS2 Adaptor/scaffold Q8C180 327826 10|10 D2 mouse Y471-p 473102 PTRRTELyAVIDIER molecular association, regulation SHP-2(NOT_REPORTED) 9632781 2 2 15 -HSPB1 HSP27 Chaperone; Heat shock protein; Motility/polarity/chemotaxis; SUMO LIGASE; SUMO ligase P15991 hamster S15-p 448401 FSLLRSPsWEPFRDW activity, induced; molecular association, regulation; protein conformation apoptosis, altered IKKA(INDUCES); HSP27(DISRUPTS) 15033973; 15944157; 16840786; 31441240 52 78 30 -Yy1 YY1 C2H2-type zinc finger protein; Cell development/differentiation; Transcription factor Q00899 22632 12 F1|12 59.58 cM mouse T30-p 25236712 LHEIEVEtIPVETIE molecular association, regulation; phosphorylation transcription, induced; signaling pathway regulation CBX4(DISRUPTS) 22482732 1 0 0 -APP APP iso4 Apoptosis; Cell surface; Membrane protein, integral; Receptor, misc.; Transcription factor P05067-4 351 21q21.3 human Y687-p 450343 NGYENPTyKFFEQMQ APP_amyloid protein stabilization; protein processing; intracellular localization 17596701; 17873282 4 12 238 -H3C1 H3 DNA-binding P68431 8350 6p22.2 human K122-ub 10834888 KRVTIMPkDIQLARR Histone molecular association, regulation SMARCC2(DISRUPTS) 32188943 0 10 31 cryo-EM; Rsc4 in yeast -NPM1 NPM1 Nucleolus; Oncoprotein; RNA-binding; Translation P06748 4869 5q35.1 human T219-p 449023 KDSKPSStPRSKGQE molecular association, regulation RNA(DISRUPTS) 12058066 1 20 24 -HNRNPD hnRNP D0 RNA splicing; RNA-binding Q14103 3184 4q21.22 human S87-p 449337 SNSSPRHsEAATAQR phosphorylation transcription, induced; RNA stability, altered RNA(INDUCES) 11903055; 12819194; 36041631 4 14 0 -NOLC1 NOLC1 Nucleolus; RNA-binding; Transcription, coactivator/corepressor Q14978 9221 10q24.32 human S563-p 470282 NGKAAKNsEEEEEEK molecular association, regulation CK2A1(INDUCES) 24218616 1 59 38 -RGS10 RGS10 iso1 GAP; GAP, RGS O43665-1 6001 10q26.11 human S168-p 455907 QTAAKRAsRIYNT__ intracellular localization apoptosis, inhibited; signaling pathway regulation 11443111; 22564151 3 3 7 PKA-CREB-Bcl2 anti-apoptotic pathway -Map2 MAP2 iso3 Cytoskeletal; Motility/polarity/chemotaxis P15146-3 25595 9q32 rat K364-ac 62495513 RPGGGRVkIESVKLD Tubulin-binding cytoskeletal reorganization 28002468 1 1 0 -Rela NFkB-p65 DNA-binding; Nuclear receptor co-regulator; Transcription factor Q04207 19697 19 A|19 4.34 cM mouse S534-p 447800 SGDEDFSsIADMDFS activity, induced; protein degradation; molecular association, regulation; intracellular localization; protein processing; phosphorylation cell differentiation, inhibited; carcinogenesis, induced; cell motility, induced; apoptosis, induced; transcription, induced; signaling pathway regulation; transcription, altered; chromatin organization, altered; cell growth, induced; transcription, inhibited p300(INDUCES); p90RSK(INDUCES) DNA(DISRUPTS) 15858576; 16135789; 16498455; 18056447; 19609947; 19965984; 20710027; 27555662; 31932498; 32161168; 32473126; 33537817; 33684929; 33930463; 34082382; 34161773; 34380537; 34496234; 35051616; 35210557; 35449211; 35637461; 35641033; 36081816; 36223242; 36309088; 36416450; 36938407; 37311534; 37392853 254 4 0 -Klc1 KLC1 Microtubule-binding; Motor O88447 16593 12 F1|12 61.13 cM mouse S459-p 477826 YKACKVDsPTVTTTL molecular association, regulation CLSTN1(DISRUPTS) 21385839 3 41 3 -Scn8a SCN8A Channel, sodium; Membrane protein, integral; Membrane protein, multi-pass Q9WTU3 20273 15 56.39 cM|15 F1 mouse Y1945-p 14828400 STASLPSyDSVTKPD molecular association, regulation; activity, inhibited NEDD4L(INDUCES) 20530479 1 0 0 -Nr3c1 GR DNA-binding; Mitochondrial; Nuclear receptor; Transcription factor P06536 24413 18p11 rat K313-sm 2532300 LCTPGVIkQEKLGPV GCR transcription, inhibited 14663148 7 3 0 -Abl1 Abl EC 2.7.10.2; KINASE; Kinase, protein; Oncoprotein; Protein kinase, TK; Protein kinase, tyrosine (non-receptor) P00520 11350 2 21.86 cM|2 B mouse T547-p 450294 EQKDAPDtPELLHTK enzymatic activity, induced cytoskeletal reorganization 15632178 2 0 0 -HSP90AA1 HSP90A Chaperone; Heat shock protein P07900 3320 14q32.31 human T90-p 476047 NKQDRTLtIVDTGIG HATPase_c molecular association, regulation exocytosis, altered; cell growth, altered HSP70(DISRUPTS); CHIP(INDUCES); PKCG(DISRUPTS); STI1(DISRUPTS); Src(DISRUPTS); PPP5C(INDUCES); TEBP(INDUCES); CDC37(DISRUPTS); AHSA1(INDUCES); Akt1(DISRUPTS) 19965370; 21919888 2 2 1 HSP90 secretion leading to proinvasiveness; T90 phosphorylation regulates the HSP90A co-chaperone machinery and binding affinity with client proteins. -ACO1 IREB1 Carbohydrate Metabolism - citrate (TCA) cycle; Carbohydrate Metabolism - glyoxylate and dicarboxylate; EC 4.2.1.3; Endoplasmic reticulum; Lyase; RNA-binding; Translation P21399 48 9p21.1 human S138-p 451387 DFNRRADsLQKNQDL Aconitase protein degradation; molecular association, regulation; enzymatic activity, inhibited cell growth, induced RNA(INDUCES) 12972614; 16424901; 19269970; 28768766 6 0 1 maintain cell viability -MAP4 MAP4 Cytoskeletal; Motility/polarity/chemotaxis P27816 4134 3p21.31 human K871-ac 62495525 TSTSSMKkTTTLSGT cytoskeletal reorganization 28002468 1 1 0 -CCDC50 CCDC50 Inhibitor Q8IVM0 152137 3q28 human Y217-p 6377637 MAEEKKAyKKAKERE phosphorylation apoptosis, inhibited; cell growth, altered 19059208 1 0 0 ; inhibits NF-kB activity; inhibits phosphorylation of IKKbeta through TNFalpha -CDC14A CDC14A EC 3.1.3.16; EC 3.1.3.48; Motility/polarity/chemotaxis; PHOSPHATASE; Protein phosphatase, dual-specificity Q9UNH5 8556 1p21.2 human S549-p 1216243800 SNGGNLNsPPGPHSA molecular association, regulation 30089874 1 1 0 interaction with putative unknown substrates or regulators -MAP3K11 MLK3 EC 2.7.11.25; KINASE; Kinase, protein; Protein kinase, Ser/Thr (non-receptor); Protein kinase, TKL Q16584 4296 11q13.1 human S770-p 448612 LISRPRPsPLRSRID phosphorylation; enzymatic activity, induced cell cycle regulation; carcinogenesis, induced; cell growth, induced 35843311 2 4 0 -Ptpn5 STEP EC 3.1.3.48; Membrane protein, multi-pass; Motility/polarity/chemotaxis; PHOSPHATASE; Protein phosphatase, tyrosine (non-receptor) P35234 29644 1q22 rat S49-p 448294 GLQERRGsNVSLTLD ubiquitination; enzymatic activity, inhibited 20427654 9 0 0 -Ptpn12 PTP-PEST EC 3.1.3.48; Motility/polarity/chemotaxis; PHOSPHATASE; Protein phosphatase, tyrosine (non-receptor) P35831 19248 5|5 A3 mouse S39-p 451311 FMRLRRLsTKYRTEK molecular association, regulation; intracellular localization; enzymatic activity, inhibited cell motility, induced; cell adhesion, induced SKAP2(DISRUPTS) 19919952; 23897807; 36250939 5 0 15 -Pi4k2a PI4K2A EC 2.7.1.67; Kinase, lipid; Motility/polarity/chemotaxis Q2TBE6 84095 19 C3|19 35.74 cM mouse S47-p 468434 AAAGSGPsPPCSPGH protein degradation; molecular association, regulation; intracellular localization LAMP1(INDUCES); AP3D1(INDUCES) 25083612 2 73 6 Regulates the lysosomal degradation -Stxbp1 STXBP1 Vesicle O08599 20910 2 B|2 22.09 cM mouse Y473-p 450386 ERISEQTyQLSRWTP Sec1 protein conformation exocytosis, inhibited 29150433 1 4 212 prevents SNARE assembly, inhibits SNARE-dependent membrane fusion, inhibition of synaptic transmission in neurons -GNB2 G-beta 2 G protein; G protein, heterotrimeric; G protein, heterotrimeric beta P62879 2783 7q22.1 human K23-ub 8100707 NQIRDARkACGDSTL phosphorylation signaling pathway regulation 34342229 1 9 27 KCTD2/KCTD5-CUL3-RING E3 ligase promotes cAMP signaling in cancer-derived cell lines -FANCD2 FANCD2 DNA repair, damage Q9BXW9 2177 3p25.3 human S882-p 1871613600 DGSKTSSsDTLSEEK FancD2 molecular association, regulation; ubiquitination; intracellular localization; activity, inhibited cell cycle regulation; DNA repair, inhibited; signaling pathway regulation DNA(DISRUPTS) 31167143 1 1 0 inhibits Fanconi anemia pathway leading to inhibition of DNA repair; 882-898 cluster -PSEN2 PSEN2 Cell surface; EC 3.4.23.-; Membrane protein, integral; Membrane protein, multi-pass; Protease P49810 5664 1q42.13 human S327-p 448564 DPEMEEDsYDSFGEP Presenilin; Presenilin protein stabilization apoptosis, inhibited 9990034 2 0 0 Phosphorylation of Presenilin 2 inhibits its cleavage by caspase-3. -FOXO4 FOXO4 DNA-binding; Oncoprotein; Transcription factor P98177 4303 Xq13.1 human T455-p 448570 ALGTPVLtPPTEAAS intracellular localization cell cycle regulation; transcription, induced 11689711; 15538382 3 3 0 -MAP3K5 ASK1 EC 2.7.11.25; KINASE; Kinase, protein; Protein kinase, STE; Protein kinase, Ser/Thr (non-receptor) Q99683 4217 6q23.3 human T813-p 990312 GDNVLINtYSGVLKI Pkinase transcription, altered 17937911 1 0 0 -PDK1 PDHK1 EC 2.7.11.2; KINASE; Kinase, protein; Mitochondrial; Protein kinase, Ser/Thr (non-receptor); Protein kinase, atypical Q15118 5163 2q31.1 human T346-p 13831355 APRPRVEtSRAVPLA HATPase_c enzymatic activity, induced cell growth, induced 27505672 1 3 0 mitochondrial Akt-PDK1 signaling in maintaining tumor cell proliferation in hypoxia -Cttn Cortactin Actin-binding; Cytoskeletal; Motility/polarity/chemotaxis Q60598 13043 7|7 F5 mouse K181-ac 3807125 VGFDYQGkTEKHESQ HS1_rep molecular association, regulation; acetylation; intracellular localization DIP2A(INDUCES) 31600191 1 2 4 DIP2A regulates spine morphology and synaptic transmission through acetylation of cortactin; Interaction of DIP2A-cortactin is required for acetylated cortactin; acetylation mimetic cortactin rescues the repetitive behaviors in Dip2a KO mice; acetylation alleviated abnormal PSD95 clustering at the spine head in DIP2A KO neurons -THOC5 FMIP Cell development/differentiation; RNA splicing; Spliceosome Q13769 8563 22q12.2 human S5-p 453432 ___MSSEsSKKRKPK intracellular localization 15221008 1 0 0 -RAF1 RAF1 EC 2.7.11.1; KINASE; Kinase, protein; Oncoprotein; Protein kinase, Ser/Thr (non-receptor); Protein kinase, TKL P04049 5894 3p25.2 human S338-p 447742 RPRGQRDsSYYWEIE activity, induced; molecular association, regulation; intracellular localization; protein conformation; phosphorylation; enzymatic activity, induced cell cycle regulation; carcinogenesis, induced; cell growth, inhibited; cell growth, induced; apoptosis, inhibited; signaling pathway regulation Bcl-2(INDUCES); RAF1(DISRUPTS); PLK1(INDUCES); MEK1(INDUCES); 14-3-3 beta(DISRUPTS) 10712905; 10998357; 11274179; 11447113; 12077328; 12244094; 12446733; 12551923; 12719581; 12865432; 15470067; 15849194; 16129686; 16585161; 18775988; 19282665; 19595761; 22081024; 22169110; 31213532; 35417664; 35697074; 9234708; 9823899 92 2 7 -Stmn1 STMN1 Cytoskeletal P13668 29332 5q36 rat S16-p 448554 KELEKRAsGQAFELI Stathmin apoptosis, inhibited; cytoskeletal reorganization TUBA1B(DISRUPTS); TUBB(DISRUPTS) 16982419; 25285524; 31933182 38 98 61 increase microtubule depolymerization -TP53 p53 Activator; DNA-binding; Motility/polarity/chemotaxis; Nuclear receptor co-regulator; Transcription factor; Tumor suppressor P04637 7157 17p13.1 human K320-ne 486297 SSSPQPKkKPLDGEY P53_tetramer activity, inhibited transcription, inhibited 17098746 1 0 0 -ATG16L1 ATG16L1 Adaptor/scaffold; Autophagy; Membrane protein, peripheral Q676U5 55054 2q37.1 human K151-m1 1079821901 ECLDLRTkLCDLERA ATG16 apoptosis, induced; autophagy, inhibited 29634390 1 1 0 methylation at K151 inhibits phosphorylation of ATG16L1 at S139 -FERMT2 kindlin-2 Cytoskeletal; Motility/polarity/chemotaxis Q96AC1 10979 14q22.1 human S180-p 3208611 PGSGSIYsSPGLYSK protein degradation; molecular association, regulation; ubiquitination cell cycle regulation; cell growth, induced; apoptosis, inhibited; cytoskeletal reorganization; cell adhesion, inhibited CUL9(INDUCES) 35469017 1 4 2 -Nr4a2 NR4A2 DNA-binding; Nuclear receptor Q06219 18227 2 C1.1|2 31.66 cM mouse S126-p 487424 SVYYKPSsPPTPSTP intracellular localization 25752609 3 0 0 cytoplasmic translocation, required for H2O2-induced necrosis -FLT1 VEGFR1 EC 2.7.10.1; KINASE; Kinase, protein; Membrane protein, integral; Protein kinase, TK; Protein kinase, tyrosine (receptor) P17948 2321 13q12.3 human Y794-p 455807 SSEIKTDyLSIIMDP phosphorylation cell cycle regulation; cell differentiation, altered 11350975; 16946136 2 0 1 angiogenesis -FYN Fyn EC 2.7.10.2; KINASE; Kinase, protein; Oncoprotein; Protein kinase, TK; Protein kinase, tyrosine (non-receptor) P06241 2534 6q21 human Y531-p 447883 FTATEPQyQPGENL_ activity, induced; intracellular localization; enzymatic activity, inhibited; protein conformation; phosphorylation cell growth, altered 1533589; 15713745; 17389760; 1985196 19 15 1040 Localization of Fyn is modulated by PDEF in cells expressing wild-FES (WT6-8 cells) , but not in cells with inactive FES (KE5-15). -Xrcc6 Ku70 DNA repair, damage; DNA-binding; EC 3.6.4.-; EC 4.2.99.-; Helicase; Nuclear receptor co-regulator; RNA-binding P23475 14375 15 E1|15 38.33 cM mouse S6-p 452070 __MSEWEsYYKTEGE molecular association, regulation BAX(DISRUPTS) 19664609 3 7 0 kainate treatment increases interaction of Ku70 with Bax -CASTOR1 GATSL3 Q8WTX7 652968 22q12.2 human S14-p 25293269 EHRVRVLsVARPGLW Castor1_N protein degradation; molecular association, regulation; ubiquitination; protein conformation; enzymatic activity, induced cell cycle regulation; carcinogenesis, induced; cell growth, induced RNF167(INDUCES); WDR59(DISRUPTS); MIOS(DISRUPTS); WDR24(DISRUPTS) 33594058; 37083230 2 0 1 induces mTORC1 activity -ZNF746 PARIS C2H2-type zinc finger protein; Transcription regulation Q6NUN9 155061 7q36.1 human K286-sm 55465778 EDVKIVIkTEVQEEE transcription, inhibited 33077496 2 2 0 -NDFIP2 NDFIP2 Adaptor/scaffold; Membrane protein, integral; Membrane protein, multi-pass Q9NV92 54602 13q31.1 human Y171-p 15229530 TEVYGEFyPVPPPYS DUF2370 molecular association, regulation; phosphorylation LYN(INDUCES) 20534535 1 0 1 Y167, Y177 and Y186 phosphorylation are dependent on Y171 phosphorylation -Rps6ka3 RSK2 EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, AGC; Protein kinase, Ser/Thr (non-receptor) P18654 110651 X F4|X 73.27 cM mouse S386-p 448065 HQLFRGFsFVAITSD Pkinase_C molecular association, regulation; phosphorylation; enzymatic activity, induced PDK1(INDUCES) 10480933; 10856237 14 19 59 -Nr4a2 NR4A2 DNA-binding; Nuclear receptor Q07917 54278 3q21 rat K91-sm 2407417 SGQQSSIkVEDIQMH transcription, inhibited 14559918; 23358114 2 0 0 -CDCA8 Borealin Cell cycle regulation; Nucleolus Q53HL2 55143 1p34.3 human S275-p 482836 RLAQICSsIRTHK__ Borealin cell growth, altered 17483322 1 1 0 -Bub1 BUB1 Cell cycle regulation; EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, Other; Protein kinase, Ser/Thr (non-receptor) O08901 12235 2 F1|2 62.1 cM mouse T449-p 4275007 CKVQPSPtVHTKEAL molecular association, regulation; protein conformation Mad1(INDUCES) 34013668 2 1 0 -ELK1 ELK1 DNA-binding; Transcription factor P19419 2002 Xp11.23 human K249-sm 3982500 RALPPEVkVEGPKEE sumoylation; intracellular localization cell differentiation, inhibited; transcription, induced; transcription, inhibited 14992729; 15210726; 17036045; 30789974 6 1 0 Both ELK1 and ELK-3R promote transcription, K230R, K249R, K254R does not prevent ELK1 SUMOylation, ELK1 and ELK1-3R show same intracellular localization -YAP1 YAP1 Oncoprotein; Transcription, coactivator/corepressor P46937 10413 11q22.1 human K252-ub 1881250301 EIYYINHkNKTTSWL protein degradation; ubiquitination cell motility, inhibited 33939216 2 0 0 TNBC cell migration and invasion -Naca NACA iso2 Motility/polarity/chemotaxis; Transcription, coactivator/corepressor Q60817 17938 10|10 D3 mouse S99-p 31834914 TRVTIRKsKNILFVI NAC intracellular localization transcription, induced 24550008; 35055125 2 1 0 -PRKG1 PKG1 EC 2.7.11.12; KINASE; Kinase, protein; Protein kinase, AGC; Protein kinase, Ser/Thr (non-receptor) P00516 282004 cow T517-p 452153 GFGKKTWtFCGTPEY Pkinase enzymatic activity, induced 29602907 3 4 13 activation loop of the catalytic domain -GYS1 GYS1 Carbohydrate Metabolism - starch and sucrose; EC 2.4.1.11; Transferase P13807 2997 19q13.33 human T278-p 1875332700 KRKPDIVtPNGLNVK Glycogen_syn phosphorylation 34758018 1 1 0 primes phopshorylation at S641 -EZH2 EZH2 EC 2.1.1.43; METHYLTRANSFERASE; Methyltransferase; Methyltransferase, protein lysine Q15910 2146 7q36.1 human S76-gl 31823503 HILTSVSsLRGTREC protein stabilization; methylation carcinogenesis, induced 24474760 1 1 0 increases H3K27me3 -Mafa MAFA DNA-binding; Oncoprotein; Transcription factor; Tumor suppressor Q8CF90 378435 15|15 D3 mouse K32-sm 6124705 DLMKFEVkKEPPEAE cell growth, inhibited; transcription, inhibited 20718938 2 0 0 -H3C1 H3 DNA-binding P68431 8350 6p22.2 human T45-p 455679 PHRYRPGtVALREIR Histone molecular association, regulation apoptosis, induced; transcription, altered DNA(INDUCES) 19363025; 22158034 5 7 3 repression of E-cadherin expression, upregulation of fibronectin expression -MAP3K7 TAK1 EC 2.7.11.25; KINASE; Kinase, protein; Protein kinase, Ser/Thr (non-receptor); Protein kinase, TKL O43318 6885 6q15 human T178-p 3303400 LKICDFGtACDIQTH PK_Tyr_Ser-Thr phosphorylation; enzymatic activity, induced 18617512; 20538596 3 0 0 facilitates autophosphorylation of T184 and T187 -NPM1 NPM1 Nucleolus; Oncoprotein; RNA-binding; Translation P06748 4869 5q35.1 human T237-p 449560 KQEKTPKtPKGPSSV molecular association, regulation; intracellular localization cell cycle regulation; cell motility, induced; cell growth, induced; cytoskeletal reorganization ROCK2(INDUCES) RNA(DISRUPTS) 12058066; 14670079; 26536659; 26993766; 30453269 7 26 21 stress fiber formation was enhanced, invasion and migration of HCC cells -Btk Btk EC 2.7.10.2; KINASE; Kinase, protein; Protein kinase, TK; Protein kinase, tyrosine (non-receptor) P35991 12229 X E3|X 56.18 cM mouse S115-p 463807 EGPLYVFsPTEELRK PH molecular association, regulation PIN1(INDUCES) 16644721 1 0 0 Interaction with Pin1 negatively regulates Btk expression. -Wnk4 WNK4 EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, Other; Protein kinase, Ser/Thr (non-receptor) Q80UE6 69847 11|11 D mouse K1123-ub 40323304 ELQNLRQkHLSEVEA protein degradation 23576762 1 1 0 regulates electrolyte homeostasis and involved in Pseudohypoaldosteronism type II (PHAII) pathogenesis -PPP1R1C PPP1R1C Motility/polarity/chemotaxis; Protein phosphatase, regulatory subunit Q8WVI7 151242 2q31.3-q32.1 human T34-p 2807902 QIRKRRPtPASLVIL DARPP-32 activity, induced cell cycle regulation; cell growth, altered 18310074 1 0 0 activates inhibition of PP1, and increases cell growth -PRKCD PKCD EC 2.7.11.13; KINASE; Kinase, protein; Nuclear receptor co-regulator; Protein kinase, AGC; Protein kinase, Ser/Thr (non-receptor); Protein kinase, tyrosine (non-receptor); Tumor suppressor Q05655 5580 3p21.1 human T507-p 447511 FGESRAStFCGTPDY Pkinase sumoylation; intracellular localization; phosphorylation; enzymatic activity, induced apoptosis, altered; signaling pathway regulation 12393602; 16505477; 18652571; 21730054; 24632950; 28784722; 31511386; 34089566 51 21 108 PKCD T507A mutant caused apoptosis in transfected HEK293T cells, similar to the wild-type. ; phosphorylation induces sumoylation which reciprocally induces phosphorylation; Histamine/PMA-induced PKCD/ERK/PARP1 signaling pathway for H1R gene regulation; 507A disrupts DKD activity; induces phosphorylation of lamin A/C -XRCC1 XRCC1 DNA repair, damage P18887 7515 19q13.31 human K431-ac 1878191201 EAPKLPQkQPQTKTK protein degradation 31043584 1 1 0 -KIR3DL1 KIR3DL1 Membrane protein, integral; Receptor, misc. P43629 3811 19q13.42 human S385-p 990304 AGNRTANsEDSDEQD activity, induced; receptor internalization, altered 17911614 1 0 0 -AKT1 Akt1 EC 2.7.11.1; KINASE; Kinase, protein; Oncoprotein; Protein kinase, AGC; Protein kinase, Ser/Thr (non-receptor) P31749 207 14q32.33 human K8-ub 12723503 MSDVAIVkEGWLHKR PH intracellular localization; phosphorylation; enzymatic activity, induced 19713527 2 3 0 promotes Akt membrane recruitment and phosphorylation, resulting in activation -Eps8 EPS8 Adaptor/scaffold Q08509 13860 6 G1|6 66.78 cM mouse T628-p 9467900 SAPSPPPtPAPVPVP intracellular localization cytoskeletal reorganization 19564905 1 1 1 -PLK4 PLK4 EC 2.7.11.21; KINASE; Kinase, protein; Nucleolus; Protein kinase, Other; Protein kinase, Ser/Thr (non-receptor) O00444 10733 4q28.1 human K46-ac 62518202 AIKMIDKkAMYKAGM Pkinase enzymatic activity, inhibited; protein conformation; phosphorylation cell cycle regulation 27796307 1 1 0 inhibits phosphorylation of its kinase domain, prevents centrosome amplification -Ankrd54 ANKRD54 Cell cycle regulation Q91WK7 223690 15 E1|15 37.7 cM mouse S19-p 239773906 SRSGRSSsDGECAVA molecular association, regulation; intracellular localization LYN(INDUCES) 28924458 1 1 0 nuclear export, cytoplasmic accumulation -Grin2b NMDAR2B Channel, calcium; Channel, ligand-gated; Membrane protein, integral; Membrane protein, multi-pass Q01097 14812 6 G1|6 66.38 cM mouse Y1070-p 461055 ISTHTVTyGNIEGNA NMDAR2_C molecular association, regulation; phosphorylation neural plasticity; signaling pathway regulation Fyn(INDUCES) 26229100; 34433031 3 2 136 induces phosphorylation at Y1472, regulates mTOR signaling; regulated by synaptic activity -BMX Etk EC 2.7.10.2; KINASE; Kinase, protein; Protein kinase, TK; Protein kinase, tyrosine (non-receptor) P51813 660 Xp22.2 human Y566-p 448067 RYVLDDQyVSSVGTK PK_Tyr_Ser-Thr protein stabilization; molecular association, regulation apoptosis, induced; cell growth, altered STAT3(INDUCES); PIK3R1(INDUCES) 10688651; 14532277; 27601470 3 1 4 -Ctnnd1 CTNND1 Actin-binding; Adaptor/scaffold; Cell adhesion; G protein regulator, misc.; Motility/polarity/chemotaxis P30999 12388 2 D|2 49.45 cM mouse Y257-p 450397 APSRQDVyGPQPQVR cell cycle regulation; cell motility, altered 18515860 2 27 754 -PPARGC1A PGC-1 alpha Nuclear receptor co-regulator; Transcription, coactivator/corepressor Q9UBK2 10891 4p15.2 human S266-p 448008 SLPLTPEsPNDPKGS protein stabilization 11741533 3 3 0 -POLDIP3 SKAR RNA-binding Q9BY77 84271 22q13.2 human S383-p 454010 ELPRRVNsASSSNPP activity, induced ERH(NOT_REPORTED) 15341740; 16984396 2 5 8 phosphorylation of this site is involved in the control of cell growth -DEPTOR DEPTOR Apoptosis Q8TB45 64798 8q24.12 human S291-p 4723858 CGSSGYFsSSPTLSS protein degradation; molecular association, regulation; ubiquitination BTRC(INDUCES); FBW1B(INDUCES) 22017876; 22017877 2 1 0 -BORA BORA Activator Q6PGQ7 79866 13q21.33 human T501-p 2512943 QMDSGYNtQNCGSNI protein degradation; molecular association, regulation; ubiquitination cell cycle regulation BTRC(INDUCES); BRD8(INDUCES) 18378770; 18521620; 23592782; 34759346 5 0 0 -FGFR2 FGFR2 iso18 EC 2.7.10.1; KINASE; Kinase, protein; Membrane protein, integral; Oncoprotein; Protein kinase, TK; Protein kinase, tyrosine (receptor) P21802-18 2263 10q26.13 human Y656-p 472825 DINNIDYyKKTTNGR PK_Tyr_Ser-Thr molecular association, regulation; intracellular localization CD44(INDUCES) 27107424 2 6 36 colocalization with CD44 -HJURP HJURP Histone-binding; Nucleolus Q8NCD3 55355 2q37.1 human S412-p 453537 RTLKWLIsPVKIVSR HJURP_C molecular association, regulation; intracellular localization cell cycle regulation OIP5(DISRUPTS) 24519934; 28017591 2 25 8 prevents premature CENP-A assembly; Mis18 binds with HJURP and specifies the centromere localization -Prkcd PKCD EC 2.7.11.13; KINASE; Kinase, protein; Nuclear receptor co-regulator; Protein kinase, AGC; Protein kinase, Ser/Thr (non-receptor); Protein kinase, tyrosine (non-receptor); Tumor suppressor P28867 18753 14 B|14 18.82 cM mouse Y64-p 447581 TTFDAHIyEGRVIQI molecular association, regulation; intracellular localization; enzymatic activity, inhibited carcinogenesis, inhibited; apoptosis, induced KPNA2(INDUCES) 11739733; 11812791; 18059334; 21865164 7 3 31 PKCD-induced apoptosis -Camkk1 CAMKK1 EC 2.7.11.17; KINASE; Kinase, protein; Protein kinase, Other; Protein kinase, Ser/Thr (non-receptor) P97756 60341 10q24 rat S458-p 486077 KSMLRKRsFGNPFEP molecular association, regulation; enzymatic activity, inhibited Calmodulin(DISRUPTS) 9195898 5 25 21 -Asic1 ASIC1 Channel, cation; Membrane protein, integral; Membrane protein, multi-pass; Transporter; Transporter, ion channel P55926 79123 7q36 rat S476-p 458230 CQKEAKRsSADKGVA activity, inhibited apoptosis, altered 16301179 1 0 0 -RBM25 RBM25 RNA splicing; RNA-binding; Spliceosome P49756 58517 14q24.2 human K77-m1 58123403 DHPGLKAkENDENCG molecular association, regulation L3MBTL iso4(INDUCES) 23583077 0 1 0 -PTPN5 STEP EC 3.1.3.48; Membrane protein, multi-pass; Motility/polarity/chemotaxis; PHOSPHATASE; Protein phosphatase, tyrosine (non-receptor) P54829 84867 11p15.1 human T255-p 20745210 SLTLDMCtPGCNEEG protein stabilization 21777200 1 0 0 -Lck Lck EC 2.7.10.2; KINASE; Kinase, protein; Oncoprotein; Protein kinase, TK; Protein kinase, tyrosine (non-receptor) P06240 16818 4 D2.2|4 63.26 cM mouse Y394-p 447822 RLIEDNEyTAREGAK PK_Tyr_Ser-Thr molecular association, regulation; intracellular localization; phosphorylation; enzymatic activity, induced carcinogenesis, induced; carcinogenesis, inhibited; cell motility, induced; transcription, induced; signaling pathway regulation; cell differentiation, induced; cell growth, induced; cell motility, altered BAT3(INDUCES) 12121665; 14699120; 17719247; 2250907; 22863785; 27271569; 33420490; 33684096; 35150959; 35638332; 36376335 62 96 2957 induces phosphorylation of PLCG1, LAT and ZAP70 -VAMP8 VAMP8 Membrane protein, integral; Vesicle Q9BV40 8673 2p11.2 human S55-p 12738929 TEDLEATsEHFKTTS Synaptobrevin activity, inhibited 27402227 1 10 0 abolish function in SNARE complex during mast cell secretion, reduces in vitro ensemble vesicle fusion -NPM1 NPM1 Nucleolus; Oncoprotein; RNA-binding; Translation P06748 4869 5q35.1 human Y67-p 3179290 VEAEAMNyEGSPIKV Nucleoplasmin protein conformation NPM1(DISRUPTS) 25490769 1 18 6 destabilizes oligomers -Smurf1 SMURF1 EC 6.3.2.-; EC 6.3.2.19; Ligase; UBIQUITIN LIGASE; Ubiquitin conjugating system; Ubiquitin ligase Q9CUN6 75788 5|5 G2 mouse T306-p 18156100 VDHNNRTtQFTDPRL WW intracellular localization cell growth, altered 21262463 2 0 0 alters SMURF1 substrate affinity and preference; contributes to neuronal polarization by promoting axon formation -Sik1 SIK EC 2.7.11.1; KINASE; Kinase, protein; Motility/polarity/chemotaxis; Protein kinase, CAMK; Protein kinase, Ser/Thr (non-receptor); Tumor suppressor Q9R1U5 59329 20p12 rat S577-p 465992 FQEGRRAsDTSLTQG intracellular localization transcription, induced; transcription, altered 12530628; 15511237; 23349925 10 21 4 Wild-type and S577A mutant induce MEF2 transcriptional activity and are nuclear localized.; S577 may be involved in nuclear export from the nucleus. -BCL10 Bcl-10 Apoptosis; Transcription, coactivator/corepressor; Tumor suppressor O95999 8915 1p22.3 human S134-p 467254 DGATNNLsRSNSDES activity, induced; molecular association, regulation MALT1(DISRUPTS) 16818229; 21199863 3 8 3 -RTN1 RTN1 Cell development/differentiation; Endoplasmic reticulum; Membrane protein, integral; Membrane protein, multi-pass Q16799 6252 14q23.1 human K772-ac 12167600 QAKIPGAkRHAE___ molecular association, regulation; acetylation apoptosis, induced DNA(DISRUPTS) 19668229 1 0 0 Inhibits histone acetylation -Csf1r CSFR EC 2.7.10.1; KINASE; Kinase, protein; Membrane protein, integral; Oncoprotein; Protein kinase, TK; Protein kinase, tyrosine (receptor) P09581 12978 18 E1|18 34.41 cM mouse Y559-p 450118 ERYEGNSyTFIDPTQ activity, induced; protein degradation; molecular association, regulation; enzymatic activity, induced; phosphorylation cell cycle regulation; transcription, induced; transcription, altered; cell differentiation, altered; apoptosis, inhibited; cell motility, altered; cytoskeletal reorganization; cell growth, altered GRB2(INDUCES); Src iso1(INDUCES); GAB2(INDUCES); CBL(INDUCES); PIK3R1(INDUCES) 10727433; 11287610; 17420255; 17420256; 18519746; 21041311 10 1 6 -SMURF2 SMURF2 EC 6.3.2.-; EC 6.3.2.19; Ligase; UBIQUITIN LIGASE; Ubiquitin conjugating system; Ubiquitin ligase Q9HAU4 64750 17q23.3-q24.1 human R234-m2 56854400 RLAERRVrSQRHRNY protein degradation 26126536 1 0 0 -WDR77 WDR77 Adaptor/scaffold; Nuclear receptor co-regulator; Transcription, coactivator/corepressor Q9BQA1 79084 1p13.2 human T5-p 471217 ___MRKEtPPPLVPP carcinogenesis, altered 20951943 1 80 72 in CCND1 T286A mutant -Rbl2 Rb-like 2 Transcription, coactivator/corepressor; Tumor suppressor Q64700 19651 8 C4|8 44.25 cM mouse K1079-ac 15207808 YFSNSPSkRLREINS intracellular localization; phosphorylation cell cycle regulation 20676144; 23029429; 35385527 3 1 0 enhances phosphorylation of Rb-like2; primes phosphorylation of itself -Cdh13 CDH13 Cell adhesion; Membrane protein, GPI anchor Q9WTR5 12554 8 E1|8 65.97 cM mouse Y327-p 486281 ETLENPKyELIIEAQ Cadherin protein degradation 17631504 1 0 0 S327F mutant is resistant to proteosomal degradataion -MYC Myc DNA-binding; Nucleolus; Oncoprotein; Transcription factor P01106 4609 8q24.21 human S363-p 466011 KCTSPRSsDTEENVK carcinogenesis, inhibited; transcription, inhibited 24030976 3 7 0 -SLBP SLBP RNA-binding Q14493 7884 4p16.3 human K156-ub 41495287 IAYDRYIkEVPRHLR SLBP_RNA_bind cell cycle regulation; RNA splicing, induced; chromatin organization, altered; cell growth, induced 27203182 1 4 0 regulation of histone mRNA processing, DNA replication during S-phase -MAGEA11 MAGE-A11 Cancer Testis Antigen (CTA); Transcription, coactivator/corepressor P43364 4110 Xq28 human K245-ub 2028409 RVKGLITkAEMLGSV MAGE protein degradation; molecular association, regulation; ubiquitination transcription, induced MAGE-A6(DISRUPTS) 23853093; 28542476 3 0 0 induce activation of E2F1; MageA6 interaction with MageA11 prevents MageA11 ubiquitination -Nfkbia IkB-alpha DNA-binding; Inhibitor Q63746 25493 6q23 rat S36-p 448204 RHDSGLDsMKDEDYE activity, induced apoptosis, altered; transcription, altered 16316997; 16407217 99 2 6 A S32A,S36A double mutant of IkBA inhibits the NFkB/p65-induced increase in dor (delta opiod receptor) promoter transcription; Cells expressing IKBa S32A S36A are more susceptible to apoptosis while in suspension than cells expressing wt IKBa. -SIAH2 SIAH2 EC 6.3.2.-; EC 6.3.2.19; Ligase; Transcription, coactivator/corepressor; UBIQUITIN LIGASE; Ubiquitin conjugating system; Ubiquitin ligase O43255 6478 3q25.1 human S28-p 471339 PQPQHTPsPAAPPAA protein degradation; molecular association, regulation; intracellular localization; enzymatic activity, induced cytoskeletal reorganization HIPK2(DISRUPTS) 19043406; 22878263; 23044042; 26751770 6 2 0 -PIK3C3 PIK3C3 Autophagy; Carbohydrate Metabolism - inositol phosphate; EC 2.7.1.137; Kinase, lipid; Motility/polarity/chemotaxis Q8NEB9 5289 18q12.3 human S249-p 35483209 ESSPILTsFELVKVP carcinogenesis, induced; autophagy, induced; cell growth, induced; apoptosis, inhibited 26118643; 33531625 2 1 0 -H3c1 H3 DNA-binding P68433 360198 13|13 A3.1 mouse K27-ac 465521 LATKAARkSAPATGG Histone phosphorylation cell cycle regulation; cell differentiation, altered; transcription, induced; transcription, altered 20561915; 25772242; 32341358; 35810562 74 18 13 transcription maintained at normal levels; MYST3 inhibits cellular senescence; DYRK1A inhibition decreases KAT6A and WDR82 phosphorylation and induces H3K27ac and H3K4me3 modi?cation, pharmacological inhibition or genetic deletion of DYRK1A promotes cardiomyocyte cell cycle activation and cardiac repair; modulated during differentiation and epigenitic reprograming -Etv4 ETV4 DNA-binding P28322 18612 11 D|11 65.48 cM mouse K138-ac 26373307 SPRQIAIkSPAPGAP ETS_PEA3_N sumoylation transcription, induced 21543453 1 1 0 acetylated sites inhibits sumoylation reciprocally -INTS11 INTS11 EC 3.1.27.-; RNA processing; Ribonuclease Q5TA45 54973 1p36.33 human K462-sm 1883375204 GISLGLLkREMAQGL molecular association, regulation; intracellular localization 36454007 1 0 0 regulates Integrator subcellular localization and interaction with integrator subunits -FANCI FANCI Cell cycle regulation; DNA repair, damage Q9NVI1 55215 15q26.1 human S556-p 11952934 VLGSLSSsQCSQSLS FANCI_HD2 molecular association, regulation; ubiquitination DNA repair, induced; cell growth, inhibited FANCD2(INDUCES); MCM5(DISRUPTS) DNA(INDUCES) 25843623; 32117957 4 2 0 prevents deubiquitination of FANCD2; inhibits dormant origin firing -Map3k7 TAK1 EC 2.7.11.25; KINASE; Kinase, protein; Protein kinase, Ser/Thr (non-receptor); Protein kinase, TKL Q62073 26409 4|4 A5 mouse S427-gl 59087900 GTEPGQVsSRSSSPS phosphorylation; enzymatic activity, induced apoptosis, inhibited; cytoskeletal reorganization 27542620 1 1 0 O-GlcNAc modi?cation TAK1 autophosphorylation ; macrophage polarization, NF-?B activation and cytokine release -CEBPB C/EBP-beta DNA-binding; Motility/polarity/chemotaxis; Transcription factor P17676 1051 20q13.13 human T235-p 447878 SSSSPPGtPSPADAK activity, induced; sumoylation; molecular association, regulation; phosphorylation cell differentiation, altered; transcription, induced; transcription, altered EHMT2 iso4(DISRUPTS); p300(INDUCES) 12213825; 16009338; 17540774; 18647749; 19723873; 21980398; 23782693; 33762327 33 11 14 -NEK6 NEK6 EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, Other; Protein kinase, Ser/Thr (non-receptor) Q9HC98 10783 9q33.3 human S206-p 448024 SETTAAHsLVGTPYY Pkinase activity, induced; enzymatic activity, induced cell growth, induced 12840024; 20595392 3 15 60 -UBQLN4 UBQLN4 Q9NRR5 56893 1q22 human S318-p 482228 GNSDSSSsQPLRTEN molecular association, regulation cell cycle regulation; DNA repair, induced MRE11A(INDUCES) 30612738 1 3 0 interaction with ubiquitinated MRE11A -SSRP1 SSRP1 Nucleolus; RNA-binding; Transcription initiation complex; Transcription, coactivator/corepressor Q08945 6749 11q12.1 human S657-p 456295 KSSSRQLsESFKSKE activity, inhibited transcription, altered 15659405 1 12 2 -CACB CACNA1C Channel, calcium; Membrane protein, integral; Membrane protein, multi-pass P15381 100101555 rabbit S1517-p 460572 DYLTRDWsILGPHHL Ion_trans activity, induced 16537462; 16820363 5 1 0 -FCRL4 FCRL4 Membrane protein, integral Q96PJ5 83417 1q23.1 human Y463-p 22730004 PKKGDLVySEIQTTQ molecular association, regulation signaling pathway regulation Ig-alpha(INDUCES) 21908428; 25972488 2 0 0 all 3 sites (Y451, Y463, Y493) inhibits BCR signaling and enhances TLR9 signaling -Cers2 LASS2 DNA-binding; Membrane protein, integral; Membrane protein, multi-pass; Transferase Q924Z4 76893 3|3 F2.1 mouse S348-p 469770 SDREETEsSEGEETA enzymatic activity, induced 26887952 1 41 179 -NFE2L2 NRF2 DNA-binding; Transcription factor Q16236 4780 2q31.2 human K518-ac 7106319 AQNCRKRkLENIVEL bZIP_Maf molecular association, regulation transcription, induced DNA(INDUCES) 19273602 1 1 0 -FZR1 FZR1 UBIQUITIN LIGASE; Ubiquitin conjugating system Q9UM11 51343 19p13.3 human S151-p 467929 DVSPYSLsPVSNKSQ protein stabilization; molecular association, regulation; activity, inhibited cell cycle regulation APC1(DISRUPTS); CDC23(DISRUPTS) 26083744; 29084198; 30498084 3 13 1 -CD81 CD81 Membrane protein, integral; Membrane protein, multi-pass P60033 975 11p15.5 human K11-ub 4666603 EGCTKCIkYLLFVFN Tetraspanin protein degradation 18713730 1 0 0 cell surface downregulation of tetraspanins -Insr INSR EC 2.7.10.1; KINASE; Kinase, protein; Membrane protein, integral; Protein kinase, TK; Protein kinase, tyrosine (receptor) P15208 16337 8 A1.1|8 1.82 cM mouse Y1179-p 447681 RDIYETDyYRKGGKG PK_Tyr_Ser-Thr cell cycle regulation; cell motility, altered 18515860 52 36 707 -Afap1l1 AFAP1L1 Unknown function Q8BZI0 106877 18|18 E1 mouse Y557-p 462143 QWPEPRIyDEVPYEK molecular association, regulation cell motility, induced; cytoskeletal reorganization NCK2(INDUCES) 26212012 1 2 4 -KLF5 KLF5 C2H2-type zinc finger protein; DNA-binding; Transcription factor Q13887 688 13q22.1 human K369-ac 458937 RSNPDLEkRRIHYCD protein degradation; protein stabilization; ubiquitination cell growth, inhibited; cell differentiation, induced; cell growth, induced; transcription, induced; transcription, inhibited; transcription, altered BAP1(DISRUPTS) 14612398; 26372456; 32685011; 35342356; 36509121 5 1 1 inhibited Basal-like breast cancer (BLBC) cell growth, and decreased KLF5 protein levels; increased KLF5 protein levels, enhanced cisplatin chemoresistance in TNBC, Inhibiting p27 transcription -XRCC4 XRCC4 DNA repair, damage Q13426 7518 5q14.2 human K296-ub 53332702 QENQLQEkENSRPDS XRCC4 ubiquitination; intracellular localization DNA repair, induced DNA(INDUCES) 26774286 1 0 0 recruitment to DNA damage sites -PKM PKM Carbohydrate Metabolism - glycolysis and gluconeogenesis; Carbohydrate Metabolism - pyruvate; EC 2.7.1.40; KINASE; Kinase, other; Mitochondrial; Nucleotide Metabolism - purine P14618 5315 15q23 human T45-p 476071 PPITARNtGIICTIG PK molecular association, regulation; enzymatic activity, inhibited; intracellular localization; phosphorylation cell cycle regulation; carcinogenesis, induced; cell growth, induced PKM iso2(DISRUPTS); MRLC2V(INDUCES) 25412762; 36198360 2 6 1 -NCL NCL DNA-binding; Helicase; Nuclear receptor co-regulator; Nucleolus; RNA-binding P19338 4691 2q37.1 human S145-p 449269 KNAKKEDsDEEEDDD intracellular localization cell cycle regulation; cell growth, induced 25313645 1 68 84 -Tbc1d4 AS160 GAP; GAP, Rab Q8BYJ6 210789 14|14 E2.3 mouse S348-p 455922 QPRRRHAsAPSHVQP PID phosphorylation 33872597 9 57 335 affects phosphorylation of other sites by AKT -Runx2 AML3 iso5 DNA-binding; Transcription factor Q08775-5 12393 17 B3|17 21.33 cM mouse S319-p 10892802 SYLSQMTsPSIHSTT activity, induced; acetylation; intracellular localization carcinogenesis, induced; cell differentiation, induced; cell motility, induced; chromatin organization, altered; transcription, induced 20484411; 22072425; 22337141; 25867060; 26206105; 27341689 11 1 0 -CDCA5 CDCA5 Cell cycle regulation Q96FF9 113130 11q13.1 human S79-p 470691 AVQSPRRsPRISFFL molecular association, regulation; activity, inhibited cell cycle regulation SCC-112(DISRUPTS); H2A.1(DISRUPTS); SMC3(DISRUPTS) 21878504; 23901111 3 18 2 -CHMP4C CHMP4C Vesicle Q96CF2 92421 8q21.13 human S214-p 1247825 ARRSRAAsSQRAEEE cell cycle regulation 22724069 2 4 8 mutations of site increase cytokinesis failure -H2ax H2AX DNA repair, damage; DNA-binding; Helicase P27661 15270 9 A5.2|9 24.84 cM mouse Y142-p 3397700 ASQASQEy_______ cell cycle regulation; DNA repair, induced; chromatin organization, altered; apoptosis, induced; apoptosis, inhibited 31902729; 34330317 10 2 2 -Trex1 TREX1 Cell cycle regulation; DNA repair, damage; DNA-binding; Deoxyribonuclease; EC 3.1.11.2 Q91XB0 22040 9|9 F2 mouse S261-p 2579810 PLATANGsPSNGRSR transcription, altered RPN1(DISRUPTS) 28297665 1 7 0 -RSF1 HBXAP Transcription, coactivator/corepressor Q96T23 51773 11q14.1 human S1359-p 3072999 ENVGKVGsPLDYSLV cell cycle regulation 26259146 1 46 6 plays a role in PLK1 recruitment and deposition on mitotic kinetochores -AKTIP AKTIP Apoptosis; Membrane protein, peripheral; Vesicle Q9H8T0 64400 16q12.2 human T190-p 20797700 RVFYKIDtASPLNPE UQ_con receptor internalization, induced; intracellular localization; phosphorylation endocytosis, induced 21777610 1 0 0 enhanced phosphorylation of JNK, p38 and EGFR -Ptpn11 SHP-2 EC 3.1.3.48; Motility/polarity/chemotaxis; PHOSPHATASE; Protein phosphatase, tyrosine (non-receptor) P35235 19247 5|5 F mouse Y580-p 448493 REDSARVyENVGLMQ molecular association, regulation; phosphorylation; enzymatic activity, induced GRB2(INDUCES) 11779868; 18827006 18 60 1189 ERK phosphorylation/activation -ERG ERG DNA-binding; Oncoprotein; Transcription factor P11308 2078 21q22.2 human K92-ac 56394101 CSVAKGGkMVGSPDT molecular association, regulation carcinogenesis, induced; transcription, induced BRD4(INDUCES) 27223260 3 1 0 -CERS2 LASS2 DNA-binding; Membrane protein, integral; Membrane protein, multi-pass; Transferase Q96G23 29956 1q21.3 human S348-p 469770 SDREETEsSEGEEAA enzymatic activity, induced 26887952 1 41 179 -MT-CO1 COX1 EC 1.9.3.1; Energy Metabolism - oxidative phosphorylation; Membrane protein, integral; Membrane protein, multi-pass; Mitochondrial; Oxidoreductase P00395 4512 - human K319-ac 1879877104 IAIPTGVkVFSWLAT apoptosis, induced 31647884 1 0 0 mutant sites were found to significantly suppressed the AAPH-evoked increase in both ROS level and apoptosis -HMOX1 HMOX1 Cofactor and Vitamin Metabolism - porphyrin and chlorophyll; EC 1.14.99.3; Oxidoreductase P09601 3162 22q12.3 human K256-ac 206219704 PVETPRGkPPLNTRS molecular association, regulation carcinogenesis, induced; cell motility, induced; cell growth, induced JunD(INDUCES) 28846111 1 1 0 Interaction leads to AP-1 transcriptional activation -NEK9 NEK9 Autophagy; EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, Other; Protein kinase, Ser/Thr (non-receptor) Q8TD19 91754 14q24.3 human T210-p 451116 SEYSMAEtLVGTPYY Pkinase enzymatic activity, induced cell cycle regulation 14660563; 16079175; 21642957 4 0 0 -GCSAM GCET2 Unknown function Q8N6F7 257144 3q13.2 human Y148-p 463675 ARSPEDEyELLMPHR HGAL activity, induced cell motility, altered; signaling pathway regulation MYO3A(INDUCES); MYO5B(INDUCES) 17823310; 31362927 2 6 179 regulates B cell receptor signaling -ABL1 Abl EC 2.7.10.2; KINASE; Kinase, protein; Oncoprotein; Protein kinase, TK; Protein kinase, tyrosine (non-receptor) P00519 25 9q34.12 human Y232-p 450302 VYGVSPNyDKWEMER intracellular localization; protein conformation 21347248 3 6 255 -BORA BORA Activator Q6PGQ7 79866 13q21.33 human S274-p 9318308 TSPSPISsPTFSPIE protein degradation; molecular association, regulation cell cycle regulation PIN1(INDUCES) 23442801; 23970419 2 2 0 required for mitotic entry -EIF2AK2 PKR EC 2.7.10.2; EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, Other; Protein kinase, Ser/Thr (non-receptor); Protein kinase, tyrosine (non-receptor); Translation P19525 5610 2p22.2 human Y101-p 458271 EGLSMGNyIGLINRI dsrm enzymatic activity, induced translation, altered; cell growth, altered 16373505 1 1 0 -EGFR EGFR EC 2.7.10.1; KINASE; Kinase, protein; Membrane protein, integral; Oncoprotein; Protein kinase, TK; Protein kinase, tyrosine (receptor) P00533 1956 7p11.2 human K1188-ac 14991105 AKPNGIFkGSTAENA receptor internalization, induced; phosphorylation endocytosis, induced; signaling pathway regulation 20513767 1 1 0 induces AKT phosphorylation and hence ERK1/2 signaling -ORC2 ORC2 DNA replication Q13416 4999 2q33.1 human S188-p 21507302 SEYSASNsEDDEGVA cell cycle regulation; carcinogenesis, induced; apoptosis, inhibited; transcription, induced 21947279; 23188630 2 0 0 -KCNQ1 Kv7.1 Channel, potassium; Membrane protein, integral; Membrane protein, multi-pass P51787 3784 11p15.5-p15.4 human S27-p 2999203 LPGARRGsAGLAKKC activity, induced; molecular association, regulation; protein conformation KCNE1(INDUCES) 12835205; 22095730; 25037568 4 2 0 cAMP-mediated upregulation of channel IKS K+ current -GRIA1 GluR1 Channel, calcium; Channel, ligand-gated; Membrane protein, integral; Membrane protein, multi-pass P42261 2890 5q33.2 human S849-p 448565 FCLIPQQsINEAIRT activity, induced 18305116 94 4 3 enhanced GluR1 currents -TACC3 TACC3 Cell cycle regulation Q9Y6A5 10460 4p16.3 human S558-p 474537 ESALRKQsLYLKFDP molecular association, regulation; intracellular localization cell cycle regulation; carcinogenesis, induced; autophagy, induced; cell growth, induced; cytoskeletal reorganization CLTC(INDUCES); CLTA(INDUCES) 17545617; 21297582; 31932847; 33805672; 36221072 12 15 43 -MYC Myc DNA-binding; Nucleolus; Oncoprotein; Transcription factor P01106 4609 8q24.21 human K290-ac 458886 EKRQAPGkRSESGSP Myc_N molecular association, regulation ZBTB17(INDUCES) 16126174 2 2 0 induces association with ZBTB17 on specific target promoters -RACK1 RACK1 Adaptor/scaffold; G protein; G protein, heterotrimeric; G protein, heterotrimeric beta; Motility/polarity/chemotaxis; Nuclear receptor co-regulator P63244 10399 5q35.3 human S63-p 56567300 QRALRGHsHFVSDVV WD40 molecular association, regulation autophagy, induced ATG5(INDUCES) 27325703 1 1 0 -P2RY1 P2RY1 GPCR, family 1; Membrane protein, integral; Membrane protein, multi-pass; Receptor, GPCR P47900 5028 3q25.2 human S354-p 1985600 EANLQSKsEDMTLNI receptor internalization, altered 21108629 1 2 0 -Sh2b2 APS Adaptor/scaffold Q9Z200 114203 12q12 rat Y618-p 448842 ARAVENQySFY____ molecular association, regulation Cbl-c(INDUCES) 11997497 2 3 5 -ANGPTL8 EG624219 Secreted; Secreted, signal peptide Q6UXH0 55908 19p13.2 human S94-p 1869062301 AAQELRAsLLETQME phosphorylation 32344005 1 0 0 enhances Akt phosphorylation, regulates signaling pathway AKT-GSK3 ?/-FoxO1 through Akt phosphorylation -KIF23 KIF23 iso2 Microtubule-binding; Motility/polarity/chemotaxis; Motor Q02241-2 9493 15q23 human S710-p 470674 LRHRRSRsAGDRWVD MKLP1_Arf_bdg molecular association, regulation cell cycle regulation 14-3-3 zeta(INDUCES); 14-3-3 gamma(INDUCES) 20451386 5 7 0 -Mok MOK EC 2.7.11.22; KINASE; Kinase, protein; Protein kinase, CMGC; Protein kinase, Ser/Thr (non-receptor) Q9WVS4 26448 12|12 F1 mouse T159-p 450005 VYSKQPYtEYISTRW Pkinase activity, induced 10421840 1 1 0 While the authors did not prove that these sites were phosphorylated, mutation of both T159 and Y161, located in the activation loop, abolished the enzymatic activity of the kinase. -NCOA2 SRC-2 Motility/polarity/chemotaxis; Nuclear receptor co-regulator; Transcription, coactivator/corepressor Q15596 10499 8q13.3 human S469-p 4728825 NYALKMNsPSQSSPG NCOA_u2 transcription, induced 22158970 2 6 3 -PML PML Nucleolus; Oncoprotein; SUMO LIGASE; SUMO conjugating system; SUMO ligase; Transcription factor; Tumor suppressor; Ubiquitin conjugating system P29590 5371 15q24.1 human S562-p 6835502 RVVVISSsEDSDAEN DUF3583 molecular association, regulation SUMO2(INDUCES); SUMO1(INDUCES); SUMO3(INDUCES) 19217413; 19380586 2 6 0 PML interaction with SUMO-modified protein partners and PML nuclear bodies maturation -EIF2AK2 PKR EC 2.7.10.2; EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, Other; Protein kinase, Ser/Thr (non-receptor); Protein kinase, tyrosine (non-receptor); Translation P19525 5610 2p22.2 human T258-p 448087 DMKETKYtVDKRFGM enzymatic activity, induced 11152499; 9528799 2 0 0 -PAK6 PAK6 EC 2.7.11.1; KINASE; Kinase, protein; Nuclear receptor co-regulator; Protein kinase, STE; Protein kinase, Ser/Thr (non-receptor) Q9NQU5 56924 15q15.1 human T354-p 29666303 SPAGSPRtWHAQIST molecular association, regulation; enzymatic activity, induced carcinogenesis, induced; cell motility, induced AR(INDUCES) 24130878 1 1 0 promotion of cell motility and invasion -MEF2C MEF2C iso3 DNA-binding; Transcription factor Q06413-3 4208 5q14.3 human T293-p 448000 QSAQSLAtPVVSVAT activity, induced transcription, altered 9069290 2 0 0 -Ern1 IRE1 Apoptosis; Chaperone; EC 2.7.11.1; Endoplasmic reticulum; KINASE; Kinase, protein; Membrane protein, integral; Protein kinase, Other; Protein kinase, Ser/Thr (non-receptor); Ribonuclease Q9EQY0 78943 11|11 E1 mouse S724-p 7161100 KLAVGRHsFSRRSGV Pkinase phosphorylation; enzymatic activity, induced RNA splicing, induced; RNA splicing, altered; apoptosis, induced; transcription, induced; transcription, altered 21911379; 26306048; 33610548; 35500653; 35863429 18 2 0 -PRKACA PKACA EC 2.7.11.11; KINASE; Kinase, protein; Protein kinase, AGC; Protein kinase, Ser/Thr (non-receptor) P17612 5566 19p13.12 human Y70-p 1269647501 HKETGNHyAMKILDK Pkinase molecular association, regulation; intracellular localization; enzymatic activity, induced cytoskeletal reorganization LARP2(INDUCES); AKAP9(INDUCES); AKAP5(DISRUPTS); CDK5RAP2(INDUCES); PDE4DIP(INDUCES); LARP(INDUCES); ANXA1(INDUCES) 30274258 1 1 0 -Pde3a PDE3A EC 3.1.4.17; Membrane protein, integral; Membrane protein, multi-pass; Nucleotide Metabolism - purine; Phosphodiesterase Q9Z0X4 54611 6|6 G2 mouse S290-p 471415 GWKRRRRsSSVVAGE enzymatic activity, induced 17124499 2 2 9 activated during oocytes maturation in mouse treated with hCG ; required for insulin-dependent Xenopus oocyte maturation -HSF1 HSF1 DNA-binding; Transcription factor Q00613 3297 8q24.3 human S319-p 455483 EASPGRPsSVDTLLS Vert_HS_TF transcription, inhibited 25963659 2 8 0 under non-stressed conditions, upon heat shock S to A mutant showed 60% higher luciferase activity -H4C1 H4 DNA-binding P62805 8359 6p22.2 human K20-m3 2344825 GGAKRHRkVLRDNIQ CENP-T_C molecular association, regulation; acetylation cell cycle regulation; carcinogenesis, induced; chromatin organization, altered; transcription, altered; transcription, inhibited JMJD2A(INDUCES) 17237781; 17967882; 18470998; 18794842; 19706462; 19935671; 20053926 35 14 0 -WRN WRN Cell cycle regulation; DNA repair, damage; DNA-binding; EC 3.6.4.12; Helicase; Nucleolus Q14191 7486 8p12 human K496-sm 12004439 PTHSKCLkMERNLGL intracellular localization 15355988 1 1 0 -CCNT1 CCNT1 Cell cycle regulation; Transcription initiation complex O60563 904 12q13.11-q13.12 human S564-p 28735106 KTYSLSSsFSSSSST enzymatic activity, inhibited transcription, inhibited 23977272 1 4 0 inhibits the kinase activity of cyclin T1/Cdk9 complex -Stmn2 STMN2 Cytoskeletal P21818 84510 2q23 rat S62-p 450174 ELILKPPsPISEAPR Stathmin cytoskeletal reorganization 9525956 9 11 0 -DIABLO DIABLO Apoptosis; Mitochondrial Q9NR28 56616 12q24.31 human S67-p 29431803 AQKSEPHsLSSEALM Smac_DIABLO molecular association, regulation apoptosis, induced XIAP(INDUCES) 24038446 1 2 0 -FBXL2 FBXL2 UBIQUITIN LIGASE; Ubiquitin ligase Q9UKC9 25827 3p22.3 human K201-ub 28058800 QLEDEALkHIQNYCH protein degradation 23542741 1 0 0 -Eps8 EPS8 Adaptor/scaffold Q08509 13860 6 G1|6 66.78 cM mouse Y524-p 457963 NHQVDRNyDAVKTQP phosphorylation carcinogenesis, induced; cell motility, induced; cell growth, induced; cell adhesion, induced 28214294 3 20 399 enhanced phosphorylation of ERK and FAK, increased cell adhesion and anchorage-dependent colony formation -SLC9A1 NHE1 Membrane protein, integral; Membrane protein, multi-pass; Motility/polarity/chemotaxis; Transporter; Transporter, SLC family P19634 6548 1p36.11 human S726-p 2509107 IDPASPQsPESVDLV activity, induced apoptosis, induced 18701649 4 11 3 regulates the apoptotic alkalinizing activity of NHE1 -CCP110 CP110 Cell cycle regulation O43303 9738 16p12.3 human S45-p 35546003 FHGVAILsPLLNIEK CaM_bind intracellular localization cell cycle regulation 12361598 1 4 0 -NHE-3 NHE3 Membrane protein, integral; Membrane protein, multi-pass; Transporter; Transporter, SLC family P26432 100009430 rabbit S663-p 457469 TMRKRLEsFKSAKLG activity, induced; intracellular localization; activity, inhibited 15888551; 25480791 4 1 2 decreased surface expression of NHE3, phosphorylation of this site with other 2 sites are together necessary for activity inhibition; Dexamthasone increases NHE-3 on the membrane surface in wild-type but not in S663A mutant. ; dexamethasone stimulates activity -MCAM MCAM Cell adhesion; Membrane protein, integral P43121 4162 11q23.3 human Y641-p 458525 PGDQGEKyIDLRH__ molecular association, regulation; phosphorylation cell growth, induced; apoptosis, inhibited; signaling pathway regulation RICTOR(INDUCES) 31665642 1 5 79 complex formation inhibits ubiquitination, induces AKT phosphorylation, induces mTORC2 signaling -DGCR8 DGCR8 Nucleolus; RNA processing; RNA-binding Q8WYQ5 54487 22q11.21 human K259-sm 57676500 EEGLCAPkKRRTEEK intracellular localization carcinogenesis, inhibited; cell growth, inhibited 27436753 1 0 0 -Creb1 CREB iso1 DNA-binding; Transcription factor P15337-1 81646 9q32 rat S111-p 451808 TIAESEDsQESVDSV transcription, altered 9931297 9 3 3 -Oprm1 MOR-1 GPCR, family 1; Membrane protein, integral; Membrane protein, multi-pass; Receptor, GPCR P42866 18390 10 A1|10 1.85 cM mouse T394-p 448128 LENLEAEtAPLP___ receptor internalization, induced; receptor desensitization, induced 27707973 5 0 0 tolerance in both opioid analgesia and opioid reward -YAP1 YAP1 Oncoprotein; Transcription, coactivator/corepressor P46937 10413 11q22.1 human Y407-p 473004 SGLSMSSySVPRTPD protein degradation; molecular association, regulation; protein stabilization; ubiquitination; intracellular localization; activity, inhibited carcinogenesis, induced; carcinogenesis, inhibited; cell motility, induced; cell growth, inhibited; apoptosis, induced; transcription, induced; cell motility, inhibited; cell growth, induced; apoptosis, inhibited; transcription, inhibited SIAH1(INDUCES); p73(INDUCES) DNA(DISRUPTS) 18280240; 18701449; 25361080; 26549256; 32205868; 35041461; 35713503; 35723276; 35999654 23 3 4 -PRKCD PKCD EC 2.7.11.13; KINASE; Kinase, protein; Nuclear receptor co-regulator; Protein kinase, AGC; Protein kinase, Ser/Thr (non-receptor); Protein kinase, tyrosine (non-receptor); Tumor suppressor Q05655 5580 3p21.1 human Y374-p 464424 ELKGRGEyFAIKALK Pkinase protein stabilization; receptor recycling, induced; intracellular localization; enzymatic activity, induced carcinogenesis, induced; cell growth, induced; signaling pathway regulation 33411917 3 18 531 prevents EGFR degradation and induces its recycling, induces EGFR signaling, induces RTK activation -MAP9 MAP9 Cell cycle regulation Q49MG5 79884 4q32.1 human S289-p 15105800 SDENKENsFSADHVT cell cycle regulation 20615875 1 2 0 required for centrosome integrity during mitosis -RRN3 TIF1A Nucleolus; Transcription initiation complex Q9NYV6 54700 16p13.11 human S44-p 470000 LENDFFNsPPRKTVR activity, induced transcription, altered 15004009 2 25 9 -NEDD4L NEDD4L EC 6.3.2.-; EC 6.3.2.19; Ligase; UBIQUITIN LIGASE; Ubiquitin conjugating system; Ubiquitin ligase Q96PU5 23327 18q21.31 human T903-p 125971701 IRLLQFVtGTSRVPM HECT ubiquitination endocytosis, induced 28588583 1 0 0 -MCM3 MCM3 DNA replication; EC 3.6.4.12 P25205 4172 6p12.2 human T722-p 449197 EEMPQVHtPKTADSQ molecular association, regulation cell cycle regulation DNA(INDUCES) 21965652 2 65 62 T722 phosphorylation affects MCM3 loading onto chromatin, and MCM3 overexpression blocks S phase entry. -L1cam NCAM-L1 Cell adhesion; Membrane protein, integral Q05695 50687 Xq37 rat Y1153-p 466002 KRSKGGKySVKDKED Bravo_FIGEY molecular association, regulation; intracellular localization Ezrin(DISRUPTS) 18478542 2 0 0 -ANXA1 ANXA1 Calcium-binding; Lipid-binding P04083 301 9q21.13 human S28-p 452053 YVQTVKSsKGGPGSA intracellular localization 19428336 2 0 0 -CARD9 CARD9 Adaptor/scaffold Q9H257 64170 9q34.3 human T231-p 23017301 CKVERKHtLKLRHAM molecular association, regulation; phosphorylation signaling pathway regulation Bcl-10(INDUCES) 22265677 1 0 0 induces TAK1 phosphorylation and Dectin1 signaling -PRC1 PRC1 Cell cycle regulation; Cytoskeletal; Microtubule-binding; Motility/polarity/chemotaxis O43663 9055 15q26.1 human T616-p 7444691 TSGILNStNIQS___ molecular association, regulation cell cycle regulation; chromatin organization, altered; cytoskeletal reorganization PLK1(INDUCES) 17351640; 22621898; 23940115; 24120663 4 5 0 Dephosphorylation at T481 and phosphorylation at T616 lead to mitotic exit -NOTCH1 Notch 1 Membrane protein, integral; Motility/polarity/chemotaxis; Oncoprotein; Receptor, misc.; Transcription factor P46531 4851 9q34.3 human K2164-ac 18899513 KVRKPSSkGLACGSK intracellular localization cell growth, induced; apoptosis, inhibited 28377411 2 1 0 -GSTP1 GSTP1 EC 2.5.1.18; Other Amino Acids Metabolism - glutathione; Transferase; Xenobiotic Metabolism - drug metabolism - cytochrome P450; Xenobiotic Metabolism - metabolism by cytochrome P450 P09211 2950 11q13.2 human Y8-p 459294 MPPYTVVyFPVRGRC GST_N protein conformation; enzymatic activity, induced 19254954 2 18 233 -OPRL1 KOR-3 GPCR, family 1; Membrane protein, integral; Membrane protein, multi-pass; Receptor, GPCR P41146 4987 20q13.33 human S346-p 1868135700 LRRDVQVsDRVRSIA receptor internalization, induced; receptor desensitization, induced signaling pathway regulation 30914485 1 0 0 -KIF2C KIF2C Cancer Testis Antigen (CTA); Microtubule-binding; Motility/polarity/chemotaxis; Motor Q99661 11004 1p34.1 human S715-p 3545002 MQLEEQAsRQISSKK molecular association, regulation; enzymatic activity, induced 26206521 2 0 0 improves its MT-binding affinity, stimulates its MT depolymerization activity, accurate chromosome segregation -CHEK1 Chk1 EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, CAMK; Protein kinase, Ser/Thr (non-receptor); Tumor suppressor O14757 1111 11q24.2 human S286-p 465527 TSGGVSEsPSGFSKH intracellular localization cell cycle regulation 18983824; 21907702 5 12 14 -Wasl N-WASP Adaptor/scaffold; Motility/polarity/chemotaxis O08816 682507 4q22 rat S481-p 3149547 RSKAIHSsDEDEDDD endocytosis, induced; cytoskeletal reorganization 21610097 3 19 1 Phosphorylation induces CK2-A1 and N-WASP complex formation and regulate cell surface EGFR levels by endocytosis. Phosphorylation reduces actin polymerization. -Add1 ADD1 Cytoskeletal; Motility/polarity/chemotaxis Q9QYC0 11518 5 B2|5 17.9 cM mouse S436-p 451595 TCSPLRHsFQKQQRE intracellular localization 25344630 2 21 9 colocalized with astrocyte protein GFAP in the spinal cord -Ncoa2 SRC-2 Motility/polarity/chemotaxis; Nuclear receptor co-regulator; Transcription, coactivator/corepressor Q61026 17978 1 A3|1 4.12 cM mouse S736-p 465446 TVKQEPAsPKKKENA DUF4927 transcription, induced 16410316 4 20 10 stimulates ER-mediated transcription and proliferation -VAMP8 VAMP8 Membrane protein, integral; Vesicle Q9BV40 8673 2p11.2 human T54-p 5434062 KTEDLEAtSEHFKTT Synaptobrevin activity, inhibited 27402227 1 16 16 abolish function in SNARE complex during mast cell secretion, reduces in vitro ensemble vesicle fusion -IRS1 IRS1 Adaptor/scaffold; Motility/polarity/chemotaxis P35568 3667 2q36.3 human S636-p 447506 SGDYMPMsPKSVSAP intracellular localization carcinogenesis, induced; cell motility, induced 16914728; 27014871 41 26 1 -Nkx3-1 NKX3-1 DNA-binding; Transcription factor; Tumor suppressor P97436 18095 14 D2|14 36.02 cM mouse S186-p 4825101 KTKRKQLsEDLGVLE protein degradation carcinogenesis, induced; cell growth, induced; DNA repair, inhibited 32943441 5 3 0 -H4c2 H4 DNA-binding P62806 326620 13|13 A3.1 mouse K5-ac 458958 ___SGRGkGGKGLGK transcription, induced 17344422 72 22 516 -MCC MCC Cell cycle regulation; Tumor suppressor P23508 4163 5q22.2 human S120-p 3624826 LRSELSQsQHEVNED activity, induced cell cycle regulation 21779472 1 9 2 -PRKCI PKCI Cell adhesion; Cell development/differentiation; EC 2.7.11.13; KINASE; Kinase, protein; Motility/polarity/chemotaxis; Oncoprotein; Protein kinase, AGC; Protein kinase, Ser/Thr (non-receptor); Tumor suppressor P41743 5584 3q26.2 human T564-p 2839109 TNEPVQLtPDDDDIV Pkinase_C signaling pathway regulation 23511975 7 24 6 signaling for synaptic incorporation of AMPAR at activated synapses during LTP expression -RPS3 RPS3 Apoptosis; EC 4.2.99.18; RNA-binding; Ribosomal; Translation P23396 6188 11q13.4 human K214-sm 25218900 HVSIVEPkDEILPTT protein stabilization 21968017 1 1 0 -FANCD2 FANCD2 DNA repair, damage Q9BXW9 2177 3p25.3 human S222-p 447816 LPEILGDsQHADVGK FancD2 cell cycle regulation 12086603 3 2 0 Phosphorylation of FANCD2 on S222 is required for the IR-inducible S phase checkpoint but not the G1/S or G2/M checkpoints -Smad4 SMAD4 DNA-binding; Nuclear receptor co-regulator; Transcription, coactivator/corepressor P97471 17128 18 E2|18 49.51 cM mouse K158-sm 2793925 NAPSMLVkDEYVHDF neural plasticity; transcription, induced 29183317 8 1 0 induces spatial learning and memory -LOXL3 LOXL3 EC 1.4.3.-; Oxidoreductase; Secreted; Secreted, signal peptide P58215 84695 2p13.1 human S704-p 1881957100 PNFEVAEsDFTNNAM molecular association, regulation; enzymatic activity, induced carcinogenesis, induced; signaling pathway regulation DHODH(INDUCES) 37253718 1 1 0 prevents DHODH ubiquitination, regulates the AK2?LOXL3?DHODH pathway -MKNK2 Mnk2 EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, CAMK; Protein kinase, Ser/Thr (non-receptor); Translation Q9HBH9 2872 19p13.3 human S74-p 456328 KRGRATDsFSGRFED molecular association, regulation; enzymatic activity, inhibited carcinogenesis, inhibited ELF4(DISRUPTS) 32170339 1 11 3 -Pcdhga3 PCDHGA3 Cell adhesion; Membrane protein, integral Q91XY5 93711 18|18 B3 mouse S922-p 41590812 GNGNKKKsGKKEKK_ Cadherin_tail cytoskeletal reorganization 26139604 1 0 0 S922 phosphorylation decreases dendrite arborization. -TRIOBP Tara iso5 Actin-binding; Cytoskeletal; Motility/polarity/chemotaxis Q9H2D6-5 11078 22q13.1 human T221-p 33365503 RRKWFEAtDSRTPEV molecular association, regulation; intracellular localization TRF1(DISRUPTS) 24692559 1 1 0 required for dissociation of telomeric TRF1 at prophase or early prometaphase -EEF1A2 EEF1A2 Translation; Translation elongation Q05639 1917 20q13.33 human K55-m1 8106722 EMGKGSFkYAWVLDK GTP_EFTU molecular association, regulation L3MBTL iso4(INDUCES) 23583077 0 3 46 -AHR AHR DNA-binding; Transcription factor P35869 196 7p21.1 human S440-p 1874101918 NGTSGKDsATTSTLS protein degradation; ubiquitination autophagy, induced; transcription, induced 34198826 1 0 0 -FGFR2 FGFR2 EC 2.7.10.1; KINASE; Kinase, protein; Membrane protein, integral; Oncoprotein; Protein kinase, TK; Protein kinase, tyrosine (receptor) P21802 2263 10q26.13 human S780-p 34500854 SQPLEQYsPSYPDTR phosphorylation carcinogenesis, inhibited; cell motility, inhibited; signaling pathway regulation 31146385 1 1 0 inhibits tyrosine phosphorylation of FGFR2 and phosphorylatin of ERK1/2 and PLC, inhibits the Ras/MAPK pathway -VGLL4 VGLL4 iso4 Transcription, coactivator/corepressor Q14135-4 9686 3p25.3-p25.2 human T159-p 3195944 AGLSPTLtPGERQQN VGLL4 cell cycle regulation; cell growth, induced 28739871 1 6 1 Mitotic phosphorylation -DDIT3 DDIT3 Autophagy; DNA-binding; Oncoprotein; Transcription factor P35638 1649 12q13.3 human S79-p 448090 EVTSTSQsPHSPDSS transcription, altered 8650547 1 1 0 CHOP-Gal-4 chimeric protein induced a reporter gene expression. -H2BC3 H2B DNA-binding P33778 3018 6p22.2 human K12-ac 458956 KSAPAPKkGSKKAIT Histone transcription, altered 16283522 7 12 467 -DYNLT1 DYNLT1 Microtubule-binding; Motility/polarity/chemotaxis; Motor P63172 6993 6q25.3 human T94-p 456225 SSTDGSCtVRWENKT Tctex-1 activity, induced; molecular association, regulation; intracellular localization cell cycle regulation; cell differentiation, induced; cell growth, induced; cytoskeletal reorganization TIM-1(DISRUPTS) 21394082; 23954591; 29693725 7 0 0 T94 phosphorylation promotes proliferation of neural progenitors through modulation of ciliary resorption and G1 length. -DAXX DAXX Apoptosis; Nuclear receptor co-regulator; Nucleolus; Transcription, coactivator/corepressor Q9UER7 1616 6p21.32 human S668-p 448623 KKICTLPsPPSPLAS activity, induced; molecular association, regulation; intracellular localization; phosphorylation transcription, induced; signaling pathway regulation Exportin-1(INDUCES) 12968034; 15128734; 22199361; 23260419 4 15 0 activates c-Jun phosphorylation, increases SF1 activity, increases CYP11A1 expression in steroidogenesis; necrotic cell death induced -tpx2.L TPX2 Cell cycle regulation; Microtubule-binding Q6NUF4 398174 frog S281-p 460756 VPKPFNLsKGKRKHE intracellular localization KPNB1(INDUCES) 29276125 1 9 23 accumulation of TPX2 at the prophase centrosome -ARHGDIA RhoGDI alpha Apoptosis; Cell adhesion; Cell development/differentiation; G protein regulator, misc.; Motility/polarity/chemotaxis P52565 396 17q25.3 human S34-p 467490 YKPPAQKsIQEIQEL Rho_GDI molecular association, regulation cell adhesion, altered RHOA(DISRUPTS) 20472934; 34133221 5 28 0 -IKBKE IKKE EC 2.7.11.10; Inhibitor; KINASE; Kinase, protein; Protein kinase, Other; Protein kinase, Ser/Thr (non-receptor) Q14164 9641 1q32.1 human K231-sm 13258715 FGGPRRNkEIMYRIT Pkinase intracellular localization; phosphorylation apoptosis, inhibited; transcription, induced 20188669 1 0 0 induces NF-kB phosphorylation -Gria2 GluR2 Channel, calcium; Channel, ligand-gated; Membrane protein, integral; Membrane protein, multi-pass P19491 29627 2q33 rat Y869-p 476831 NSQNFATyKEGYNVY receptor internalization, induced 14976558 3 1 4 long-term depression of AMPA receptor-mediated excitatory postsynaptic currents -OTUB1 OTUB1 DEUBIQUITINASE; EC 3.4.19.12; Protease; Ubiquitin conjugating system; Ubiquitin-specific protease Q96FW1 55611 11q13.1 human S16-p 3208998 QKQEPLGsDSEGVNC ubiquitination; intracellular localization DNA repair, induced; carcinogenesis, inhibited; apoptosis, induced; transcription, induced 25872870; 34785775 3 14 0 nuclear localization, S16A mutant cytoplasmic localzation and impaired foci formation after IR; induces p53 deubiquitination and stabilization -CTBP1 CTBP1 iso2 Cell cycle regulation; EC 1.1.1.-; Nuclear receptor co-regulator; Oxidoreductase; Transcription, coactivator/corepressor Q13363-2 1487 4p16.3 human S147-p 455351 REGTRVQsVEQIREV 2-Hacid_dh; 2-Hacid_dh_C intracellular localization endocytosis, induced 18323776 7 2 0 facilitates infectious entry of Ad3 (virus), cytoplasmic localization -CDC25A CDC25A EC 3.1.3.48; Motility/polarity/chemotaxis; PHOSPHATASE; Protein phosphatase, dual-specificity P30304 993 3p21.31 human S40-p 63080405 ASAAGGLsPVTNLTV protein degradation cell cycle regulation 28192398 1 1 0 -Gria1 GluR1 Channel, calcium; Channel, ligand-gated; Membrane protein, integral; Membrane protein, multi-pass P19490 50592 10q22 rat K886-ac 206219720 VVSQDFPkSMQSIPC protein stabilization; ubiquitination; receptor internalization, inhibited neural plasticity 28793258 1 0 0 inhibits ubiquitination; impaired learning and memory -WBP2 WBP2 Cell development/differentiation; Nuclear receptor co-regulator Q969T9 23558 17q25.1 human K222-ub 58948901 STPAAEAkAAEAAAS protein degradation carcinogenesis, inhibited; cell growth, inhibited; transcription, inhibited 27578003 2 2 0 in vitro transformation inhibited -Tgif1 TGIF DNA-binding; Nuclear receptor co-regulator; Transcription, coactivator/corepressor P70284 21815 17|17 E1.3 mouse T235-p 1868546604 PQSGLFNtPPPTPPD molecular association, regulation carcinogenesis, induced; cell growth, induced; transcription, induced; signaling pathway regulation TWIST1(INDUCES); TWIST1(DISRUPTS) 31152009; 31268604 2 0 0 TGIF T239D/T235D mutant does not inhibit TWIST1 expression; in Kras active mutant cells; TGIF T239D/T235D mutant stimulates proliferation of Capan-2 cells -SCN1A SCN1A Channel, sodium; Membrane protein, integral; Membrane protein, multi-pass P35498 6323 2q24.3 human T1934-p 1239966003 RRHLLKRtVKQASFT molecular association, regulation Calmodulin(INDUCES) 30142967 1 0 0 -CD40 CD40 Membrane protein, integral; Receptor, cytokine P25942 958 20q13.12 human T254-p 451275 TAAPVQEtLHGCQPV activity, induced; molecular association, regulation TRAF2(INDUCES) 12133933; 1696597 2 0 0 T254 phosphorylation results in growth inhibition of M12/CD40+ cells. -PTPRA PTPRA iso6 EC 3.1.3.48; Membrane protein, integral; Motility/polarity/chemotaxis; PHOSPHATASE; Receptor protein phosphatase, tyrosine P18433-2 5786 20p13 human S180-p 447611 QAGSHSNsFRLSNGR molecular association, regulation; phosphorylation; enzymatic activity, induced cell growth, altered PIK3CB(INDUCES); Src(INDUCES); PKCD(INDUCES); GRB2(DISRUPTS) 11676480; 11923305; 23532252 6 17 0 promotes PTPRA tyrosine phosphorylation -Rps6ka3 RSK2 EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, AGC; Protein kinase, Ser/Thr (non-receptor) P18654 110651 X F4|X 73.27 cM mouse T365-p 450151 DPEFTAKtPKDSPGI Pkinase_C enzymatic activity, induced 10856237 6 36 14 -PIAS1 PIAS1 EC 6.3.2.-; Nuclear receptor co-regulator; SUMO LIGASE; SUMO conjugating system; SUMO ligase; Transcription, coactivator/corepressor O75925 8554 15q23 human S17-p 53747701 MVMSLRVsELQVLLG protein degradation; molecular association, regulation translation, inhibited HECTD2(INDUCES) 26157031 1 0 0 -KIF14 KIF14 Microtubule-binding; Motor Q15058 9928 1q32.1 human S1220-p 114810404 NLHSSHSsGLMDKSS intracellular localization 28630147 1 0 0 spindle localization of Kif14 in anaphase -Gja1 GJA1 Channel, misc.; Membrane protein, integral; Membrane protein, multi-pass; Motility/polarity/chemotaxis P23242 14609 10 B4|10 28.64 cM mouse S330-p 449994 AGSTISNsHAQPFDF Connexin43 molecular association, regulation; intracellular localization cytoskeletal reorganization; signaling pathway regulation; endocytosis, inhibited ERK1(DISRUPTS); TUBB(INDUCES) 16882687; 21527737; 31189653; 36206047 10 14 0 -CXCR2 IL8RB GPCR, family 1; Membrane protein, integral; Membrane protein, multi-pass; Receptor, GPCR; Receptor, cytokine P25025 3579 2q35 human S353-p 451049 PSFVGSSsGHTSTTL protein degradation; receptor desensitization, altered; receptor internalization, altered 9079638 1 0 0 -Cidec CIDEC Apoptosis P56198 14311 6|6 E3 mouse K224-ub 12718506 TEEEQPAkAKPSSLL protein degradation 20089860 1 0 0 -MAPK15 ERK7 EC 2.7.11.24; KINASE; Kinase, protein; Protein kinase, CMGC; Protein kinase, Ser/Thr (non-receptor) Q8TD08 225689 8q24.3 human Y177-p 459217 EDQAVTEyVATRWYR Pkinase enzymatic activity, induced apoptosis, induced 16336213; 16484222; 28467781 3 5 23 -Bach2 BACH2 DNA-binding; Transcription factor P97303 12014 4|4 A5 mouse S520-p 470117 ETRTRTSsSCSSYSY activity, induced; intracellular localization translation, induced 27158840 2 1 0 nuclear exclusion -Mapt Tau ACETYLTRANSFERASE; Acetyltransferase; Cytoskeletal P10637 17762 11 67.79 cM|11 E1 mouse K613-ac 490850600 DLSKVTSkCGSLGNI Tubulin-binding acetylation cytoskeletal reorganization 28760828 2 1 0 impedes tau filament assembly -FOXM1 FOXM1 DNA-binding; Transcription factor Q08050 2305 12p13.33 human K440-ac 57807003 LSSAGPGkEEKLLFG activity, induced; protein stabilization; molecular association, regulation; phosphorylation carcinogenesis, induced; cell growth, induced; transcription, induced DNA(NOT_REPORTED) 27542221 1 1 0 -Tp53 p53 Activator; DNA-binding; Motility/polarity/chemotaxis; Nuclear receptor co-regulator; Transcription factor; Tumor suppressor P02340 22059 11 B3|11 42.83 cM mouse K369-me 2344805 HSSYLKTkKGQSTSR acetylation 18280244 5 0 0 increases p53 acetylation at multiple sites -RRAD RRAD G protein; G protein, monomeric; G protein, monomeric, RGK P55042 6236 16q22.1 human S257-p 457395 QIRLRRDsKEANARR molecular association, regulation Calmodulin(INDUCES) 9677319 1 0 0 -MASTL MASTL EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, AGC; Protein kinase, Ser/Thr (non-receptor) Q96GX5 84930 10p12.1 human S875-p 3209091 TAQHLTVsGFSL___ protein conformation; phosphorylation; enzymatic activity, induced cell cycle regulation RSK2(INDUCES) 21444715; 27563826 3 9 0 phosphorylation induces intramolecular interaction, which inhibits dephosphorylation at the same phospho site. -H3C1 H3 DNA-binding P68431 8350 6p22.2 human K4-m3 1458621 ____ARTkQTARKST Histone molecular association, regulation; acetylation; ubiquitination; methylation; intracellular localization cell cycle regulation; carcinogenesis, induced; carcinogenesis, inhibited; cell motility, induced; apoptosis, induced; cell growth, inhibited; transcription, induced; transcription, altered; signaling pathway regulation; DNA repair, induced; cell differentiation, induced; chromatin organization, altered; cell growth, induced; transcription, inhibited UHRF1(INDUCES); requiem(DISRUPTS); CDC45L(DISRUPTS); TAF140(INDUCES); ING2(INDUCES); RBBP4(DISRUPTS); TBP(INDUCES); FALZ(INDUCES); STAT1(INDUCES); ING4(INDUCES); GATAD1(INDUCES); GADD45A(INDUCES); RCOR1(INDUCES); C17orf49(INDUCES); MLL(INDUCES); RAG2(INDUCES); H2AZ(INDUCES); GCN5(INDUCES); FOXA2(INDUCES); H2AFV(INDUCES); CCDC101(INDUCES); PHF8(INDUCES); DPF3(DISRUPTS); FALZ iso4(INDUCES); JMJD2A(INDUCES); ING1(INDUCES); HCFC1(INDUCES); TRRAP(INDUCES) DNA(INDUCES) 16728974; 16728976; 16878130; 17305432; 17310985; 17351631; 17363312; 17567990; 18234970; 18701507; 18787082; 19021773; 19187765; 19229332; 19473514; 19503595; 19523850; 19524534; 19546172; 19734945; 19805358; 19885928; 19935671; 20003410; 20033197; 20043883; 20046871; 20053357; 20053926; 20080105; 20093418; 20190764; 20346720; 20404096; 20421419; 20452361; 20484083; 20548336; 20613843; 20818375; 20850016; 20953165; 20959362; 21059703; 21489993; 21565979; 22978410; 23159437; 23285160; 23353889; 23388825; 23408432; 23423141; 23518351; 25591470; 25656485; 26301496; 26783963; 31685992; 34155378; 35322029; 35346195; 35409160; 36060800 178 10 0 -SMAD1 SMAD1 DNA-binding; Transcription factor Q15797 4086 4q31.21 human S187-p 451173 NSHPFPHsPNSSYPN intracellular localization 9335504 4 0 0 Erk-mediated phosphorylation inhibits the nuclear accumulation of Smad1. -Men1 MEN1 Transcription, coactivator/corepressor Q9WVR8 29417 1q43 rat S487-p 18012114 RRGPRREsKPEEPPP Menin molecular association, regulation cell growth, induced; transcription, induced MYH9(INDUCES); ACTB(INDUCES) 30792230 2 13 1 induce insulin mRNA level and loss of its ability to repress cell proliferation. attenuation of SUV39H1and HDAC1 mediated repression -Acaca ACC1 Carbohydrate Metabolism - propanoate; Carbohydrate Metabolism - pyruvate; EC 6.3.4.14; EC 6.4.1.2; Ligase; Lipid Metabolism - fatty acid biosynthesis P11497 60581 10q26 rat S1215-p 449868 YGMTHVAsVSDVLLD ACC_central enzymatic activity, inhibited 7915280 3 7 2 -STK26 MST4 EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, STE; Protein kinase, Ser/Thr (non-receptor) Q9P289 51765 Xq26.2 human T178-p 4274125 DTQIKRNtFVGTPFW Pkinase intracellular localization cytoskeletal reorganization 19386264 3 19 63 -Git1 GIT1 GAP; GAP, ARF; Motility/polarity/chemotaxis Q9Z272 83709 10q24 rat Y330-p 15702200 FLPVNPEySATRNQG cell growth, induced 30355914 4 0 0 -DRD2 DRD2 GPCR, family 1; Membrane protein, integral; Membrane protein, multi-pass; Receptor, GPCR P14416 1813 11q23.2 human S321-p 31010702 GLHSTPDsPAKPEKN 7tm_1 receptor internalization, induced; receptor desensitization, inhibited signaling pathway regulation 24391960 1 1 0 decreased inhibition of the cAMP pathway -TSC2 TSC2 Cell cycle regulation; GAP; GAP, misc.; Nuclear receptor co-regulator; Tumor suppressor P49815 7249 16p13.3 human S664-p 455575 KKTSGPLsPPTGPPG Tuberin activity, induced; molecular association, regulation; enzymatic activity, induced TSC1(DISRUPTS) 15851026; 20008839 9 9 1 eIF4E activation through the AKT pathway leads to progression in NSCLC -GAB2 GAB2 Adaptor/scaffold Q9UQC2 9846 11q14.1 human Y293-p 449528 ETDNEDVyTFKTPSN molecular association, regulation CRKL(INDUCES) 11334882 1 14 172 -TP53 p53 Activator; DNA-binding; Motility/polarity/chemotaxis; Nuclear receptor co-regulator; Transcription factor; Tumor suppressor P04637 7157 17p13.1 human S37-p 447532 NVLSPLPsQAMDDLM TAD2 protein degradation; acetylation; protein stabilization; molecular association, regulation; phosphorylation; activity, induced; ubiquitination; protein conformation cell cycle regulation; carcinogenesis, induced; apoptosis, altered; cell growth, inhibited; apoptosis, induced; transcription, induced; transcription, altered; DNA repair, induced; cell growth, induced; apoptosis, inhibited; transcription, inhibited FBXW7(INDUCES); S100B(INDUCES); S100A1(INDUCES); S100A4(INDUCES); CBP(INDUCES); RPA1(INDUCES); PPP2CA(INDUCES); MDM2(DISRUPTS); S100A6(INDUCES); MDM2(INDUCES); S100A2(INDUCES) 10656682; 11042698; 11314044; 14665630; 14712210; 15471885; 16501611; 17891183; 19819244; 20024960; 20962272; 22797063; 27753536; 31296660; 31940492; 35951367; 9363941; 9744860 67 2 0 -OPTN optineurin Inhibitor Q96CV9 10133 10p13 human S473-p 9511914 AQMEVYCsDFHAERA CC2-LZ ubiquitination; intracellular localization 26365381; 27035970 3 2 0 -Ilf3 NFAT90 DNA-binding; Nucleolus; RNA-binding; Transcription factor Q9Z1X4 16201 9 A3|9 7.78 cM mouse T188-p 17734001 EKVLAGEtLSVNDPP DZF molecular association, regulation; intracellular localization translation, altered ILF2(DISRUPTS) 21123651 3 1 0 -NBR1 NBR1 Ubiquitin conjugating system Q14596 4077 17q21.31 human T586-p 33602700 HNTPVDVtPCMSPLP protein stabilization; molecular association, regulation; activity, inhibited SQSTM1(DISRUPTS) 24879152 1 1 0 inhibits function as a cargo adaptor protein, inhibits protein aggregation; phosphorylation slightly reduces its interaction with SQSTM1 -DDR2 DDR2 EC 2.7.10.1; KINASE; Kinase, protein; Membrane protein, integral; Protein kinase, TK; Protein kinase, tyrosine (receptor) Q16832 4921 1q23.3 human Y736-p 456861 FGMSRNLySGDYYRI PK_Tyr_Ser-Thr phosphorylation 16186108 1 9 409 Stimulates autophosphorylation. Autophosphorylation induces Shc binding (site not determined). -RUNX2 AML3 iso2 DNA-binding; Transcription factor Q13950-2 860 6p21.1 human S451-p 460684 MVPGGDRsPSRMLPP RunxI transcription, inhibited 32009983 5 0 0 decreased PDK4 levels, induces cell viability -Epas1 HIF2A DNA-binding; Transcription factor P97481 13819 17|17 E4 mouse T844-p 451301 PYLLPELtRYDCEVN HIF-1a_CTAD transcription, induced 11983697 1 0 0 -ASL ASL Amino Acid Metabolism - alanine, aspartate and glutamate; Amino Acid Metabolism - arginine and proline; EC 4.3.2.1; Endoplasmic reticulum; Lyase; Mitochondrial P04424 435 7q11.21 human S417-p 1880040200 LQELQTIsPLFSGDV molecular association, regulation; methylation; intracellular localization carcinogenesis, induced; chromatin organization, altered; transcription, induced GABPA(INDUCES) DNA(INDUCES) 36270249 1 0 0 induces H3K4 methylation -Rps6kb1 p70S6K EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, AGC; Protein kinase, Ser/Thr (non-receptor); Translation P67999 83840 10q26 rat S447-p 448357 GSPRTPVsPVKFSPG enzymatic activity, induced 11705993; 15774499 102 54 247 -MST1R Ron EC 2.7.10.1; KINASE; Kinase, protein; Membrane protein, integral; Protein kinase, TK; Protein kinase, tyrosine (receptor) Q04912 4486 3p21.31 human Y1353-p 456487 SALLGDHyVQLPATY molecular association, regulation; phosphorylation cell growth, altered Met(INDUCES) 10871856; 11064459 5 0 0 -SQSTM1 SQSTM1 Autophagy; Nuclear receptor co-regulator; Ubiquitin conjugating system Q13501 8878 5q35.3 human K435-ac 1879848303 LDTIQYSkHPPPL__ molecular association, regulation ubiquitin(INDUCES); SQSTM1(DISRUPTS) 31857589 1 1 0 enhances p62 body formation, clearance of poly-Ub proteins -RELA NFkB-p65 DNA-binding; Nuclear receptor co-regulator; Transcription factor Q04206 5970 11q13.1 human K221-ac 459094 LLCDKVQkEDIEVYF RHD_dimer molecular association, regulation; intracellular localization carcinogenesis, induced; apoptosis, inhibited; transcription, induced IkB-alpha(DISRUPTS) DNA(INDUCES) 12456660; 17268554; 18223231; 19345327; 21940946; 27007123 12 0 0 induces JCV activation -MAP4 MAP4 Cytoskeletal; Motility/polarity/chemotaxis P27816 4134 3p21.31 human K933-ac 36293768 NTSAPDLkNVRSKVG Tubulin-binding cytoskeletal reorganization 28002468 1 2 0 -Pax7 PAX7 DNA-binding; Oncoprotein; Transcription factor P47239 18509 4 D3|4 70.83 cM mouse S201-p 50592106 GNRLDEGsDVESEPD protein stabilization 26372956; 27144531 2 4 0 early commitment to terminal differentiation.; phosphorylation blocks caspase cleavage site, restricts differentiation and increase stem cell self-renewal -ROCK2 ROCK2 EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, AGC; Protein kinase, Ser/Thr (non-receptor) Q28021 282041 cow S1133-p 1732200 LHIGLDSsSIGSGPG enzymatic activity, induced cell cycle regulation 17446864 1 3 0 alanine mutation of all 4 sites -Cacna1b CACNA1B Channel, calcium; Membrane protein, integral; Membrane protein, multi-pass Q02294 257648 3p13 rat S2108-p 465549 RKQERGRsQERRQPS activity, induced 16704976; 19167461 2 0 0 -FFAR4 GPR120 GPCR, family 1; Lipid-binding; Membrane protein, integral; Membrane protein, multi-pass; Receptor, GPCR Q5NUL3 338557 10q23.33 human S350-p 31014808 GAILTDTsVKRNDLS activity, induced 27852822 5 1 0 -EFNB2 EFNB2 Ligand, receptor tyrosine kinase; Membrane protein, integral P52799 1948 13q33.3 human Y311-p 447829 YEKVSGDyGHPVYIV protein stabilization; protein conformation 12606549 2 10 126 -Cdh2 CDH2 Cell adhesion; Membrane protein, integral; Motility/polarity/chemotaxis P15116 12558 18 A1|18 10.1 cM mouse Y884-p 450693 SSGGDQDyDYLNDWG CADH_Y-type_LIR molecular association, regulation SHC1(INDUCES) 10502299 2 0 0 -APP APP Apoptosis; Cell surface; Membrane protein, integral; Receptor, misc.; Transcription factor P05067 351 21q21.3 human K763-ub 15384677 GYENPTYkFFEQMQN APP_amyloid protein processing; intracellular localization 29021256 2 7 1 An APP mutant that lacks all C-terminal lysines increased PSEN2-mediated processing of an increased pool of APP on the endosomal membrane. -CDC25A CDC25A EC 3.1.3.48; Motility/polarity/chemotaxis; PHOSPHATASE; Protein phosphatase, dual-specificity P30304 993 3p21.31 human S283-p 58934700 PERSQEEsPPGSTKR M-inducer_phosp protein degradation; ubiquitination; enzymatic activity, induced cell cycle regulation; apoptosis, inhibited 27580187; 34363019 2 2 0 -Drd1 DRD1 GPCR, family 1; Membrane protein, integral; Membrane protein, multi-pass; Receptor, GPCR P18901 24316 17p14 rat S258-p 455302 VECAQSEsSFKMSFK 7tm_1 receptor desensitization, altered 14660631 2 0 0 -IKBKE IKKE EC 2.7.11.10; Inhibitor; KINASE; Kinase, protein; Protein kinase, Other; Protein kinase, Ser/Thr (non-receptor) Q14164 9641 1q32.1 human K30-ub 40323317 VYKARNKkSGELVAV Pkinase molecular association, regulation; phosphorylation; enzymatic activity, induced carcinogenesis, induced; cell growth, induced; transcription, induced IKKB(INDUCES); IKKG(INDUCES) 23453969 1 1 0 regulates NF-kB pathway activation- TLR signaling, enhanced CYLD phosphorylation -PGR PR DNA-binding; Nuclear receptor; Transcription factor P06401 5241 11q22.1 human K7-sm 2890600 _MTELKAkGPRAPHV Prog_receptor sumoylation; protein stabilization; intracellular localization; protein conformation transcription, inhibited 17020914 1 0 0 induces sumoylation at other sites -SVIL supervillin Actin-binding; Contractile; Motility/polarity/chemotaxis; Nuclear receptor co-regulator O95425 6840 10p11.23 human S245-p 468887 SFTEVPRsPKHAHSS phosphorylation cell cycle regulation 36576983 1 64 13 induces RLC phosphorylation -PAK1 PAK1 EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, STE; Protein kinase, Ser/Thr (non-receptor) Q13153 5058 11q13.5-q14.1 human Y285-p 487520 QGASGTVyTAMDVAT Pkinase protein stabilization; molecular association, regulation; intracellular localization; enzymatic activity, induced carcinogenesis, induced; apoptosis, altered; cell motility, induced; transcription, induced; signaling pathway regulation; cell growth, induced; cell motility, altered; cytoskeletal reorganization GIT1(INDUCES); PXN(INDUCES); ARHGEF7(INDUCES); Snail1(INDUCES) 17726028; 21566085; 21719533; 23340249; 25125660; 25466889; 26944939; 27003261; 27542844 9 1 1 PAK1 phosphorylation stimulates PRL-induced tumor metastasis -EEF2 EEF2 Translation; Translation elongation P13639 1938 19p13.3 human T57-p 448040 RAGETRFtDTRKDEQ GTP_EFTU activity, inhibited; phosphorylation cell cycle regulation; carcinogenesis, inhibited; translation, altered; cell growth, inhibited; translation, induced; translation, inhibited 19036825; 21112387; 23184662; 30218597; 30786936; 35513296; 35841486 39 61 54 -MYH10 MYH10 Motility/polarity/chemotaxis; Motor P35580 4628 17p13.1 human S1952-p 465599 QLHLEGAsLELSDDD cytoskeletal reorganization 25869664 2 44 1 poorly defined actomyosin bundles distributed throughout the cell -CARD11 CARD11 Adaptor/scaffold Q9BXL7 84433 7p22.2 human S652-p 457639 LERPFRPsVTSVGHV activity, induced transcription, induced 24548923 6 0 0 NF-kB activation, IL-2 production -Yaf2 YAF2 Transcription, coactivator/corepressor Q99LW6 67057 15|15 E3 mouse S166-p 3205731 RGVSRSSsPRGEASS cell differentiation, inhibited; transcription, inhibited 29959227 2 24 2 regulation of H2AK119ub1 at specific promoters -Bmal1 BMAL1 DNA-binding; Transcription factor Q9WTL8 11865 7 F1|7 59.17 cM mouse S519-p 1878257202 IHRIRGSsPSSCGSS activity, induced transcription, induced 35902736 1 1 0 -Tp53 p53 Activator; DNA-binding; Motility/polarity/chemotaxis; Nuclear receptor co-regulator; Transcription factor; Tumor suppressor P02340 22059 11 B3|11 42.83 cM mouse K370-ac 458980 SSYLKTKkGQSTSRH activity, induced; molecular association, regulation cell growth, inhibited; apoptosis, induced; transcription, induced DNA(INDUCES) 21057544; 25758227; 33323382; 35534985 95 4 0 HDAC6 ablation induces senescence p21 expression and inhibits cell growth, HDAC6 ablation inhibits HC proliferation after two-thirds partial hepatectomy (PHx); P53K Q/- mice died prematurely due to anemia, loss of hematopoiesis stem cells, Loss of stem cells in the testis, activation in p53 KQ/- mice without robust p53 stabilization,p53-KQ/- mutant leads to effective suppression of tumor development in a pancreatic ductal adenocarcinoma mouse model, mutant proteins extended the life-span of a PDAC mouse model -P4HB PDIA1 EC 5.3.4.1; Endoplasmic reticulum; Isomerase; Nuclear receptor co-regulator; Oxidoreductase P07237 5034 17q25.3 human S357-p 56652490 KIKPHLMsQELPEDW molecular association, regulation; protein conformation; enzymatic activity, altered apoptosis, inhibited IRE1(INDUCES) 32149426 1 2 0 -MAP2K2 MEK2 EC 2.7.12.2; KINASE; Kinase, protein; Protein kinase, STE; Protein kinase, dual-specificity (non-receptor) P36507 5605 19p13.3 human S306-p 3295100 RPPGRPVsGHGMDSR Pkinase molecular association, regulation; protein conformation carcinogenesis, induced; cell motility, induced; cell adhesion, induced Akt1(INDUCES) 28225038 2 11 0 Interaction with AKT induces FOXO1 phosphorylation; metastasis in nude mice -MOB1B MOB1B Activator; Protein kinase, regulatory subunit Q7L9L4 92597 4q13.3 human T74-p 11555108 QINMLYGtITDFCTE Mob1_phocein molecular association, regulation NDR1(INDUCES); LATS2(INDUCES) 19919647 1 0 0 -RUNX1 AML1 DNA-binding; Oncoprotein; Transcription factor Q01196 861 21q22.12 human R210-me 2363102 QLRRTAMrVSPHHPA molecular association, regulation cell differentiation, altered; transcription, induced SIN3A(DISRUPTS) DNA(DISRUPTS) 18316480 2 1 0 -Klf4 KLF4 C2H2-type zinc finger protein; DNA-binding; Transcription factor Q923V7 114505 5q24 rat S469-p 22996306 QKCDRAFsRSDHLAL zf-C2H2 molecular association, regulation transcription, inhibited PPAR-gamma(INDUCES) 22282354 1 0 0 -IGFBP1 IGFBP1 Secreted; Secreted, signal peptide P08833 3484 7p12.3 human S144-p 451659 NFHLMAPsEEDHSIL activity, induced; molecular association, regulation; activity, inhibited; phosphorylation signaling pathway regulation IGF1(INDUCES); CK2B(INDUCES) 18772238; 19193607; 23354097; 25957086; 32502935 14 11 0 regulates mTOR and AAR signaling; inhibits IGF-1RB autophosphorylation and activity; S126A and S144A mutants inhibit IGF1R autophosphorylation -Gata4 GATA4 Motility/polarity/chemotaxis; Transcription factor Q08369 14463 14 D1|14 33.24 cM mouse K322-ac 18380900 QTRKRKPkNLNKSKT cell growth, induced; transcription, induced 20833366 1 0 0 -Tie1 TIE1 EC 2.7.10.1; KINASE; Kinase, protein; Membrane protein, integral; Protein kinase, TK; Protein kinase, tyrosine (receptor) Q06806 21846 4 D2.1|4 54.67 cM mouse Y1113-p 451279 MLEARKAyVNMSLFE molecular association, regulation transcription, altered PIK3R1(INDUCES) 11865050 1 0 0 -MAPT Tau iso8 ACETYLTRANSFERASE; Acetyltransferase; Cytoskeletal P10636-8 4137 17q21.31 human K353-ub 486346 FKDRVQSkIGSLDNI Tubulin-binding protein stabilization cytoskeletal reorganization 16443603; 32575755 1 3 0 di-ubiquitin chain at position K353, moderately but signi?cantly inhibits microtubule polymerization, di-ubiquitination retards ?lament formation -H3-3A H3 DNA-binding Q71LE2 396970 pig K4-m3 1458621 ____ARTkQTARKST Histone transcription, inhibited 32893712 178 10 0 mesenchymal stem/stroma cells of obese pigs had suppressed transcription compared to lean pigs -Akt3 Akt3 EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, AGC; Protein kinase, Ser/Thr (non-receptor) Q63484 29414 13q25 rat S34-p 484936 FLLKTDGsFIGYKEK PH enzymatic activity, inhibited 17308302 1 9 0 -Syn1 SYN1 Vesicle P09951 24949 Xq11 rat Y301-p 478277 VVALTKTyATAEPFI Synapsin_C molecular association, regulation Src(INDUCES); Fyn(INDUCES) 17400547; 20530578 2 0 2 increases interaction with synaptic vesicles and actin filaments -CELF1 CELF1 Cell development/differentiation; RNA processing; RNA-binding Q92879 10658 11p11.2 human S28-p 3347300 GQVPRTWsEKDLREL RRM_1 molecular association, regulation RNA splicing, altered; translation, altered RNA(INDUCES) 18570922; 24151077 3 9 1 splicing regulation in diabetes; increases CUGBP1 binding to cyclin D1 mRNA -YY1 YY1 C2H2-type zinc finger protein; Cell development/differentiation; Transcription factor P25490 7528 14q32.2 human K288-sm 3142604 RMKPRKIkEDDAPRT transcription, inhibited 17353273 1 2 0 -Gpsm1 GPSM1 GEF; GEF, misc. Q9R080 246254 3p13 rat T625-p 1345849601 DVLPRGPtMPDEDFF intracellular localization 30404823 1 0 0 regulation distribution of GPSM1 cellular puncta by T625 phosphorylation, cell stress and G-protein signaling -ATP7A ATP7A Apoptosis; Cell development/differentiation; Chaperone; EC 3.6.3.54; Hydrolase; Membrane protein, integral; Membrane protein, multi-pass; Transporter; Transporter, ion channel; Vesicle Q04656 538 Xq21.1 human T327-p 478062 KYNASSVtPESLRKA HMA protein conformation 21258844 2 8 26 S339 alters the dynamics of domain by increasing the flexibility whereas T327 decreasing the flexibility in Cu bound MBD3 -Tpm1 TPM1 Actin-binding; Motility/polarity/chemotaxis; Motor P58771 22003 9 C|9 36.27 cM mouse S283-p 451804 HALNDMTsI______ Tropomyosin enzymatic activity, induced; phosphorylation cytoskeletal reorganization; transcription, inhibited; signaling pathway regulation 23148217; 23232082; 23960072; 30567734 11 15 94 slows the Ca2+ regulation of myofilament; S283A mutant increases phosphorylation of PLB S16; regulation of muscle contraction and relaxation; phosphorylation of TPM1 at S283 causes a decrease in phosphorylation of PLB at S16 and T17.; modulates development of cardiac hypertrophy; Impairs diastolic function, regulates ERK pathway -Gabbr1 GABBR1 GPCR, family 3; Membrane protein, integral; Membrane protein, multi-pass; Receptor, GPCR Q9WV18 54393 17 B1|17 19.16 cM mouse S867-p 15167000 ITRGEWQsEAQDTMK receptor internalization, altered endocytosis, altered 20643921 3 0 1 -BIK BIK Apoptosis; Membrane protein, integral; Mitochondrial Q13323 638 22q13.2 human K160-ub 1877656600 GGLHLLLk_______ protein degradation; ubiquitination apoptosis, inhibited 31387940 1 0 0 IRE1alpha?XBP1 axis prevents premature apoptosis allows time for cell adaptation to ER stress -EGFR EGFR EC 2.7.10.1; KINASE; Kinase, protein; Membrane protein, integral; Oncoprotein; Protein kinase, TK; Protein kinase, tyrosine (receptor) P00533 1956 7p11.2 human R222-m2 56856900 CAQQCSGrCRGKSPS Furin-like intracellular localization; protein conformation; enzymatic activity, induced cell growth, induced 26571401 1 1 0 -KEAP1 KEAP1 Endoplasmic reticulum; Motility/polarity/chemotaxis; Transcription regulation; UBIQUITIN LIGASE; Ubiquitin conjugating system Q14145 9817 19p13.2 human S104-ga 1873356118 KVVLASSsPVFKAMF BTB protein degradation; ubiquitination transcription, inhibited CUL3(INDUCES) 28663241 1 0 0 NRF2 ubiquitination and degradation -Mapk1 ERK2 EC 2.7.11.24; KINASE; Kinase, protein; Protein kinase, CMGC; Protein kinase, Ser/Thr (non-receptor) P63085 26413 16 A3|16 10.53 cM mouse Y185-p 447594 HTGFLTEyVATRWYR Pkinase intracellular localization; enzymatic activity, induced carcinogenesis, induced; carcinogenesis, inhibited; cell growth, inhibited; transcription, induced; signaling pathway regulation; transcription, altered; neural plasticity; cell growth, induced; apoptosis, inhibited; cytoskeletal reorganization GAB1(INDUCES) 10593929; 10608864; 10867029; 11934884; 1319055; 15788406; 15975986; 16103085; 19004831; 21562256; 21706057; 21813649; 21887248; 21917714; 25584415; 34107247; 34191798; 37160873; 7504457; 8444886 1163 158 4003 -CENPJ CENPJ Cell cycle regulation; Microtubule-binding; Transcription, coactivator/corepressor Q9HC77 55835 13q12.12-q12.13 human S595-p 14918201 ISFSSNSsFVLKILE cell cycle regulation 20531387 1 0 0 required for centriole elongation -Irf4 IRF4 DNA-binding; Oncoprotein; Transcription factor Q64287 16364 13|13 A3.2 mouse K349-sm 56836800 LCSDRPNkLERDQTC IRF-3 protein stabilization cell cycle regulation; cell motility, induced; cell growth, induced; cell differentiation, induced; transcription, altered 27425617 1 0 0 -Casp4 CASP4 Apoptosis; EC 3.4.22.64; Protease P70343 12363 9 A1|9 2.46 cM mouse K62-ub 1877676800 WVFVDAMkKKHSKVG CARD protein degradation 30816303 1 0 0 -Atp6v1a ATP6V1A EC 3.6.3.14; Energy Metabolism - oxidative phosphorylation; Hydrolase P50516 11964 16|16 B4 mouse S384-p 485978 YLGARLAsFYERAGR ATP-synt_ab intracellular localization 23863464 1 12 0 apical plasma membrane localization in kidney 549 intercalated cells -LEMD3 MAN1 Membrane protein, integral; Membrane protein, multi-pass; Nuclear envelope Q9Y2U8 23592 12q14.3 human S402-p 3216873 GGAFSVDsPRIYSNS molecular association, regulation BAF(INDUCES) 19166343 1 18 0 -FGFR1 FGFR1 EC 2.7.10.1; KINASE; Kinase, protein; Membrane protein, integral; Oncoprotein; Protein kinase, TK; Protein kinase, tyrosine (receptor) P11362 2260 8p11.23 human Y653-p 447918 RDIHHIDyYKKTTNG PK_Tyr_Ser-Thr phosphorylation; enzymatic activity, induced cell differentiation, altered; cell motility, altered; cell growth, altered 16507368; 8622701 16 25 316 Double Y->F mutant has less neurite outgrowth in PC12 cells (differentiation), and less cell proliferation in L-6 cells.; Data collected by isolating phosphorylated species in vitro and confirming their phosphorylation states by mass spec. Y->F mutations were also done but unpublished. -TLN1 talin 1 Cytoskeletal; Motility/polarity/chemotaxis Q9Y490 7094 9p13.3 human T150-p 9764162 GTLRKDKtLLRDEKK cell motility, altered; cell adhesion, induced 27698901 1 5 1 -Trpv2 TRPV2 Channel, cation; Membrane protein, integral; Membrane protein, multi-pass Q9WUD2 29465 10q23 rat Y335-p 1877505000 RKFTEWCyGPVRVSL activity, induced; protein stabilization endocytosis, induced 35686730 1 1 0 -NR1I3 NR1I3 DNA-binding; Nuclear receptor Q14994 9970 1q23.3 human S192-p 458347 LPIEDQIsLLKGAAV Hormone_recep intracellular localization 16377764 1 0 1 -Dynll1 LC8 Microtubule-binding; Motility/polarity/chemotaxis; Motor P63168 56455 5|5 F mouse S88-p 454241 VAILLFKsG______ Dynein_light cytoskeletal reorganization 15504720 9 0 0 -SCN5A SCN5A Channel, sodium; Membrane protein, integral; Membrane protein, multi-pass Q14524 6331 3p22.2 human S525-p 451568 TSMKPRSsRGSIFTF Na_trans_cytopl activity, induced 12242273 6 6 1 -ZFHX3 ATBF1 C2H2-type zinc finger protein; Cell development/differentiation; DNA-binding; Mitochondrial; Transcription factor Q15911 463 16q22.2-q22.3 human K2806-sm 610813726 LLSPSSIkVEGIEDF protein stabilization carcinogenesis, induced; cell growth, induced 32249212 1 1 0 -HNF4A HNF4 alpha DNA-binding; Nuclear receptor; Transcription factor P41235 3172 20q13.12 human K126-ac 460633 KCFRAGMkKEAVQNE zf-C4 molecular association, regulation; intracellular localization; protein conformation transcription, induced Exportin-1(DISRUPTS); CBP(INDUCES) DNA(INDUCES) 10882110 1 0 0 -NEDD1 NEDD1 Cell cycle regulation Q8NHV4 121441 12q23.1 human S574-p 25533015 LSEKIADsIGNNRQN molecular association, regulation cytoskeletal reorganization TUBG1(INDUCES) 22595525 1 3 0 Promote NEDD1 activity; regulates spindle assembly in mitosis -GTF2I GTF2I iso2 DNA-binding; Transcription, coactivator/corepressor P78347-2 2969 7q11.23 human Y249-p 459606 ESEDPDYyQYNIQGS cell cycle regulation; transcription, altered 16314517 5 1 1 -MAFA MAFA DNA-binding; Oncoprotein; Transcription factor; Tumor suppressor Q8NHW3 389692 8q24.3 human S14-p 1713900 MGAELPSsPLAIEYV activity, induced cell differentiation, altered; transcription, induced 11416124 2 2 0 activation of crystallin and NQO1 expression -SMURF1 SMURF1 EC 6.3.2.-; EC 6.3.2.19; Ligase; UBIQUITIN LIGASE; Ubiquitin conjugating system; Ubiquitin ligase Q9HCE7 57154 7q22.1 human T223-p 1877492900 DVRGSLQtPQNRPHG molecular association, regulation carcinogenesis, induced; cell motility, induced; cytoskeletal reorganization RHOA(INDUCES) 35654587 1 1 0 induces RhoA polyubiquitination -Ace2 ACE2 EC 3.4.17.23; Membrane protein, integral; Protease Q8R0I0 70008 X F5|X 76.12 cM mouse K788-ub 1869999601 YDSMDIGkGESNAGF protein degradation 32755395 1 0 0 -PLAGL2 PLAGL2 C2H2-type zinc finger protein; DNA-binding Q9UPG8 5326 20q11.21 human K356-ac 483052 YLPDKLPkVEVDSFL sumoylation transcription, induced 17551969 1 0 0 acetylation abolishes sumoylation on the same three residues, promoter-specific transcription -BMI1 BMI1 EC 6.3.2.-; Ligase; Motility/polarity/chemotaxis; Oncoprotein; UBIQUITIN LIGASE; Ubiquitin conjugating system; Ubiquitin ligase P35226 648 10p12.2 human S316-p 6150348 ANRPRKSsVNGSSAT molecular association, regulation carcinogenesis, inhibited; cell growth, inhibited DNA(DISRUPTS) 23092893 2 1 50 inhibits self-renewal of hematopoietic progenitor cells -ELP3 ELP3 ACETYLTRANSFERASE; Acetyltransferase; EC 2.3.1.48 Q9H9T3 55140 8p21.1 human Y202-p 450611 GHTSNNIyEAVKYSE Radical_SAM carcinogenesis, induced; cell growth, induced; transcription, induced 31341009 1 12 345 -AICDA AID EC 3.5.4.38; Hydrolase Q9GZX7 57379 12p13.31 human S38-p 457604 YVVKRRDsATSFSLD APOBEC2 enzymatic activity, induced 16387847 12 3 0 -AGO2 AGO2 EC 3.1.26.n2; RNA processing; RNA-binding Q9UKV8 27161 8q24.3 human S831-p 7104887 SAEGSHTsGQSNGRD molecular association, regulation; activity, inhibited; phosphorylation transcription, inhibited RNA(DISRUPTS) 28114302 3 5 0 induces phosphorylation at S834; regulates miRNA silencing -CDK6 CDK6 Cell cycle regulation; EC 2.7.11.22; KINASE; Kinase, protein; Protein kinase, CMGC; Protein kinase, Ser/Thr (non-receptor) Q00534 1021 7q21.2 human Y24-p 448903 AEIGEGAyGKVFKAR Pkinase molecular association, regulation; enzymatic activity, inhibited; activity, inhibited cell cycle regulation CCND3(DISRUPTS); CCND1(DISRUPTS) 23429262 1 4 248 -CHEK1 Chk1 EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, CAMK; Protein kinase, Ser/Thr (non-receptor); Tumor suppressor O14757 1111 11q24.2 human S317-p 447833 ENVKYSSsQPEPRTG protein stabilization; molecular association, regulation; enzymatic activity, inhibited; phosphorylation; enzymatic activity, induced cell cycle regulation; DNA repair, induced; carcinogenesis, induced; apoptosis, inhibited; signaling pathway regulation claspin(INDUCES) DNA(INDUCES) 11390642; 12588868; 15707391; 16963448; 18272544; 19091954; 21907702; 23454898; 24240236; 24632611; 24876101; 26082189; 26658951; 31591366; 32076484; 32357935; 33503415; 34385259; 35740300; 36781846 103 11 17 -BAK1 BAK1 Apoptosis; Endoplasmic reticulum; Membrane protein, integral; Mitochondrial Q16611 578 6p21.31 human Y110-p 15794304 TAENAYEyFTKIATS Bcl-2 activity, induced; molecular association, regulation; protein conformation apoptosis, inhibited BAK1(DISRUPTS); BID(INDUCES) 23782464 2 1 0 -MTOR mTOR Autophagy; EC 2.7.11.1; KINASE; Kinase, protein; Motility/polarity/chemotaxis; Protein kinase, Ser/Thr (non-receptor); Protein kinase, atypical P42345 2475 1p36.22 human S2448-p 447578 RSRTRTDsYSAGQSV intracellular localization; phosphorylation; enzymatic activity, induced cell cycle regulation; carcinogenesis, induced; apoptosis, induced; cell motility, induced; transcription, induced; transcription, altered; signaling pathway regulation; cell growth, induced; apoptosis, inhibited; autophagy, inhibited; translation, induced 12807916; 19079619; 21602892; 21893193; 24590173; 25020061; 31802035; 33658337; 33755959; 33835469; 33845796; 33967735; 34194551; 34604061; 34820368; 35253622; 35279705; 35368866; 35443161; 35841593; 35907820; 36008391; 36139911; 36149602; 36357572; 36413544; 36418288; 36471885; 36635496 218 18 106 -RAD51 RAD51 DNA repair, damage; Mitochondrial Q06609 5888 15q15.1 human T309-p 455229 LRKGRGEtRICKIYD Rad51 activity, induced cell cycle regulation; DNA repair, induced; carcinogenesis, altered; DNA repair, altered 15665856; 34197606; 36692427 3 0 0 -YY1 YY1 C2H2-type zinc finger protein; Cell development/differentiation; Transcription factor P25490 7528 14q32.2 human T348-p 3189352 KRHQLVHtGEKPFQC molecular association, regulation; intracellular localization DNA(DISRUPTS) 19793915 1 11 6 in mitotic cells -RGS13 RGS13 GAP; GAP, RGS O14921 6003 1q31.2 human T41-p 15785722 SFENLMAtKYGPVVY RGS protein stabilization 20974683 1 1 0 -FOXM1 FOXM1 DNA-binding; Transcription factor Q08050 2305 12p13.33 human S331-p 3194567 FKPLDPGsPQLPEHL activity, induced; molecular association, regulation cell growth, induced PIN1(INDUCES) 26279295 2 5 0 -MDC1 MDC1 Cell cycle regulation Q14676 9656 6p21.33 human S329-p 453669 QPFGFIDsDTDAEEE molecular association, regulation cell cycle regulation NBS1(INDUCES) 18678890 1 33 23 MDC1-NBS1 interaction regulates intra-S-phase checkpoint activation -NDC80 HEC1 Cell cycle regulation O14777 10403 18p11.32 human S7-p 1881198900 _MKRSSVsSGGAGRL cell cycle regulation 36897279 1 1 0 -Gja1 GJA1 Channel, misc.; Membrane protein, integral; Membrane protein, multi-pass; Motility/polarity/chemotaxis P08050 24392 20q11 rat Y265-p 447815 KDCGSPKyAYFNGCS activity, induced; molecular association, regulation; intracellular localization; activity, inhibited carcinogenesis, altered; cytoskeletal reorganization; cell adhesion, altered; cell growth, altered CTNNB1(DISRUPTS); Src(INDUCES); PTPN2(INDUCES); DBN1(INDUCES) 11124251; 14681032; 16916748; 20676131; 24849651; 27280719; 27391443; 29882937; 32956670 26 3 11 allows anchorage-independent growth; inhibits Src activity; disrupts gap junction communication; regulation of gap junction intercellular communication -TSC1 TSC1 Motility/polarity/chemotaxis; Tumor suppressor Q92574 7248 9q34.13 human S487-p 5277800 AAISRELsEITTAEA Hamartin protein degradation; molecular association, regulation; ubiquitination; phosphorylation carcinogenesis, induced; cell growth, induced; signaling pathway regulation TSC2(DISRUPTS) 17693255 2 6 3 induces S6K1 phosphorylation, activates mTOR pathway -Cryaa CRYA1 Chaperone; Heat shock protein P24622 12954 17 B1|17 17.09 cM mouse S171-p 452108 FSGPKVQsGLDAGHS HSP20 apoptosis, inhibited 29467334 5 5 0 attenuation of ER stress; regulates neuroprotective function -CDH1 CDH1 Cell adhesion; Membrane protein, integral; Motility/polarity/chemotaxis; UBIQUITIN LIGASE; Ubiquitin ligase P12830 999 16q22.1 human Y754-p 456025 DTRDNVYyYDEEGGG molecular association, regulation endocytosis, induced CBLL1(INDUCES) 22252131; 29311227 3 2 44 -TNFRSF1A TNF-R1 Membrane protein, integral; Receptor, cytokine P19438 7132 12p13.31 human S381-p 20831307 FVRRLGLsDHEIDRL Death molecular association, regulation cell motility, induced; transcription, induced TRADD(INDUCES) 21724995 1 0 0 -SIT1 SIT Adaptor/scaffold; Membrane protein, integral Q9Y3P8 27240 9p13.3 human Y90-p 448963 SVEEVPLyGNLHYLQ SIT molecular association, regulation GRB2(INDUCES) 11433379 1 10 337 Y90 is major binding site. -Atp1a1 ATP1A1 EC 3.6.3.9; Hydrolase; Membrane protein, integral; Membrane protein, multi-pass; Transporter; Transporter, ion channel P06685 24211 2q34 rat S16-p 449086 KYEPAAVsEHGDKKS protein degradation; molecular association, regulation; enzymatic activity, inhibited; intracellular localization; protein conformation; enzymatic activity, induced AP2A1(INDUCES); AP-2 alpha(INDUCES) 10716725; 10933807; 12466249; 12759348; 14976217; 16338965; 16949583; 27605582 13 25 0 -MAPK14 P38A EC 2.7.11.24; KINASE; Kinase, protein; Protein kinase, CMGC; Protein kinase, Ser/Thr (non-receptor) Q16539 1432 6p21.31 human K152-sm 1881371307 DIIHRDLkPSNLAVN protein stabilization; intracellular localization 34686655 1 0 0 nuclear translocation, metastasis, OS response -Rb1 Rb Nuclear receptor co-regulator; Oncoprotein; Transcription, coactivator/corepressor; Tumor suppressor P13405 19645 14 38.73 cM|14 D3 mouse T819-p 447984 LPTPTKMtPRSRILV Rb_C molecular association, regulation; phosphorylation cell cycle regulation; chromatin organization, altered; cell growth, induced; DNA repair, inhibited E2F1(DISRUPTS); SUV420H1(DISRUPTS); SUV420H2(DISRUPTS) 10207050; 35023164 20 37 56 -Sufu SUFU Adaptor/scaffold; Transcription, coactivator/corepressor; Tumor suppressor Q9Z0P7 24069 19 C3|19 38.85 cM mouse S346-p 4786848 RAPSRKDsLGSDSST SUFU_C intracellular localization Exportin-1(DISRUPTS) 27849569 4 30 3 nuclear localization -REM1 REM1 G protein; G protein, monomeric; G protein, monomeric, RGK O75628 28954 20q11.21 human S18-p 4697668 TPLHRRAsTPLPLSP activity, induced; molecular association, regulation 14-3-3 beta(INDUCES); CACNA1C(DISRUPTS) 22076634 1 8 5 -Pak1 PAK1 EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, STE; Protein kinase, Ser/Thr (non-receptor) O88643 18479 7 E1|7 53.57 cM mouse T423-p 448177 PEQSKRStMVGTPYW Pkinase enzymatic activity, induced 12719581 39 4 11 -Rbpms RBPMS Motility/polarity/chemotaxis Q9WVB0 19663 8|8 A4 mouse T113-p 3208557 AKNKLVGtPNPSTPL molecular association, regulation; activity, inhibited RBPMS(DISRUPTS) RNA(DISRUPTS) 36408906 1 8 1 -TSC2 TSC2 Cell cycle regulation; GAP; GAP, misc.; Nuclear receptor co-regulator; Tumor suppressor P49815 7249 16p13.3 human S1452-p 3191272 LPSSSPRsPSGLRPR activity, inhibited; phosphorylation cell cycle regulation; cell growth, induced; translation, induced 32294430 2 14 0 induces S6K phosphorylation -CDC25B CDC25B EC 3.1.3.48; Motility/polarity/chemotaxis; Nuclear receptor co-regulator; PHOSPHATASE; Protein phosphatase, dual-specificity P30305 994 20p13 human S321-p 459625 KCQRLFRsPSMPCSV M-inducer_phosp molecular association, regulation; intracellular localization; phosphorylation; enzymatic activity, induced 14-3-3 beta(DISRUPTS); 14-3-3 epsilon(DISRUPTS) 20801879 2 2 3 S321 phosphorylation disrupts binding of S323 to 14-3-3, resulting in S323 dephosphorylation -MDM2 MDM2 EC 6.3.2.-; EC 6.3.2.19; Inhibitor; Ligase; NEDDYLATION LIGASE; Neddylation Ligase; Nucleolus; Oncoprotein; UBIQUITIN LIGASE; Ubiquitin conjugating system; Ubiquitin ligase Q00987 4193 12q15 human S17-p 9184307 TDGAVTTsQIPASEQ protein degradation; molecular association, regulation; protein conformation; enzymatic activity, induced p53(INDUCES); p53(DISRUPTS) 19568783; 21191186; 22815859; 25543083 4 0 0 S17 phosphorylation gives rise to the 'closed' form of truncated lid.; increases thermostability of the isolated N-terminal domain -Ppp1r9b Spinophilin Adaptor/scaffold; Protein phosphatase, regulatory subunit Q6R891 217124 11|11 D mouse Y398-p 22879101 DLVDVSAySGLGEDS molecular association, regulation SHP-1(INDUCES) 22210881 1 0 0 -ELAVL1 HuR RNA-binding Q15717 1994 19p13.2 human K182-ub 7761225 SSEPITVkFAANPNQ protein degradation; molecular association, regulation RNA(DISRUPTS) 19322201; 26434587; 36968077 3 2 0 degradation under heat shock -FLNC FLNC Cytoskeletal; Motility/polarity/chemotaxis Q14315 2318 7q32.1 human S2623-p 27449343 KSSSSRGsSYSSIPK protein stabilization 28028127 1 3 0 -IGF1R IGF1R EC 2.7.10.1; KINASE; Kinase, protein; Membrane protein, integral; Protein kinase, TK; Protein kinase, tyrosine (receptor) P08069 3480 15q26.3 human K1055-sm 12723518 LNEASVMkEFNCHHV PK_Tyr_Ser-Thr intracellular localization cell growth, induced; transcription, induced DNA(INDUCES) 20145208; 25448401 2 0 0 -PPP1R1A PPP1R1A Inhibitor; Protein phosphatase, regulatory subunit Q13522 5502 12q13.2 human T35-p 447759 QIRRRRPtPATLVLT DARPP-32 molecular association, regulation; enzymatic activity, inhibited; enzymatic activity, induced PPP1CA(INDUCES) 10811908; 29311589 14 4 0 PKA-thiophosphorylated form of inhibitor-1 displays a different affnity to native and recombinant enzyme -Rin1 Rin1 GEF; GEF, Rab Q921Q7 225870 19|19 A mouse Y35-p 450778 KPSTDPLyDTPDTRG molecular association, regulation Arg(INDUCES) 15886098 1 39 1026 -NPR1 ANPA EC 4.6.1.2; Guanylyl cyclase; KINASE; Kinase, protein; Lyase; Membrane protein, integral; Nucleotide Metabolism - purine; Protein kinase, RGC; Protein kinase, dual-specificity (receptor); Receptor, misc. P16066 4881 1q21.3 human S534-p 447514 AGSRLTLsGRGSNYG activity, induced; enzymatic activity, induced 28416574; 9528788 3 2 1 -Nr4a1 Nur77 Apoptosis; DNA-binding; Nuclear receptor P12813 15370 15|15 F1 mouse S354-p 447942 GRRGRLPsKPKQPPD activity, inhibited transcription, altered 16223362; 9322922 11 4 0 -TP63 p63 DNA-binding; Transcription factor Q9H3D4 8626 3q28 human S160-p 451600 SSTFDALsPSPAIPS protein stabilization; intracellular localization 23420876 6 2 0 nuclear stabilization of phosphorylated p63 in response to paclitaxel, partially relocates to the mitochondria -LIMD1 LIMD1 Motility/polarity/chemotaxis; Tumor suppressor Q9UGP4 8994 3p21.31 human S272-p 451974 TASSQRVsPGLPSPN cell cycle regulation; carcinogenesis, inhibited; cell growth, inhibited; cell motility, inhibited 30600590 1 19 2 mitotic phosphorylation required for mitotic progression -EGLN2 EGLN2 EC 1.14.11.29; Oxidoreductase Q96KS0 112398 19q13.2 human S130-p 31088285 EDGGDAPsPSKRPWA molecular association, regulation cell cycle regulation HIF1A(DISRUPTS) 26644182 1 5 0 -DVL3 DVL3 Motility/polarity/chemotaxis Q92997 1857 3q27.1 human S633-p 34668137 GPAASEHsHRSHHSL Dsh_C intracellular localization 24993822 1 1 0 -Dok1 DOK1 Adaptor/scaffold; Motility/polarity/chemotaxis P97465 13448 6 C3|6 35.94 cM mouse Y295-p 448366 LGSPPALyAEPLDSL molecular association, regulation cell growth, inhibited RASA1(INDUCES) 25043303 4 14 166 -Axin1 axin 1 Adaptor/scaffold; Tumor suppressor O70239 79257 10q12 rat S317-p 2226504 YALAPATsANDSEQQ cytoskeletal reorganization 22933777 1 0 0 Phosphorylation regulates responsive to Sema3A induced growth cone collapse. -OTUD6A OTUD6A DEUBIQUITINASE; EC 3.4.19.12; Ubiquitin-specific protease Q7L8S5 139562 Xq13.1 human S70-p 40512702 LEKFQDDsSIESVVE molecular association, regulation; intracellular localization cell cycle regulation; carcinogenesis, induced TOPBP1(DISRUPTS) 35768646 1 2 0 -RNF4 RNF4 EC 6.3.2.-; Ligase; Nuclear receptor co-regulator; Transcription factor; UBIQUITIN LIGASE; Ubiquitin conjugating system; Ubiquitin ligase P78317 6047 4p16.3 human T112-p 3801490 DVYVTTHtPRNARDE enzymatic activity, induced 25948581 1 2 6 regulates homologous recombination repair during S-phase -PAK6 PAK6 EC 2.7.11.1; KINASE; Kinase, protein; Nuclear receptor co-regulator; Protein kinase, STE; Protein kinase, Ser/Thr (non-receptor) Q9NQU5 56924 15q15.1 human S560-p 450316 KDVPKRKsLVGTPYW Pkinase enzymatic activity, induced 15550393 2 15 42 -Dnm2 DYN2 EC 3.6.5.5; Hydrolase; Microtubule-binding; Motility/polarity/chemotaxis; Vesicle P39054 13430 9 A3|9 7.79 cM mouse Y231-p 451199 LLPLRRGyIGVVNRS Dynamin_M cytoskeletal reorganization 21411625 4 1 0 promotes focal adhesion turnover -ATP2A2 SERCA2 Cell adhesion; EC 3.6.3.8; Endoplasmic reticulum; Hydrolase; Membrane protein, integral; Membrane protein, multi-pass; Transporter; Transporter, ion channel P16615 488 12q24.11 human K480-sm 25092201 SVIKQLMkKEFTLEF Cation_ATPase protein stabilization; molecular association, regulation; ubiquitination; enzymatic activity, induced Other(INDUCES) 21900893 2 0 0 induces ATP binding, inhibits ubiquitination -Kcnj3 GIRK1 Channel, potassium; Membrane protein, integral; Membrane protein, multi-pass P63251 50599 3q21 rat T407-p 10769101 PSKLQKItGREDFPK activity, induced 19765080 2 0 0 -PPP1R12A MYPT1 Motility/polarity/chemotaxis; PHOSPHATASE; Protein phosphatase, regulatory subunit O14974 4659 12q21.2-q21.31 human S472-p 452042 AGVTRSAsSPRLSSS molecular association, regulation cell adhesion, altered 14-3-3 beta(INDUCES) 20354225 2 12 40 -Yap1 YAP1 Oncoprotein; Transcription, coactivator/corepressor P46938 22601 9|9 A1 mouse S382-p 3190672 TYHSRDEsTDSGLSM protein degradation; intracellular localization; activity, inhibited carcinogenesis, inhibited; carcinogenesis, altered; cell motility, induced; cell growth, inhibited; transcription, inhibited 34608264; 34678143; 35619099; 36170819; 36374802 32 13 5 -HDAC2 HDAC2 DEACETYLASE; Deacetylase; EC 3.5.1.98; Nuclear receptor co-regulator; Transcription, coactivator/corepressor Q92769 3066 6q21 human K462-sm 27490400 EDKKTDVkEEDKSKD molecular association, regulation apoptosis, inhibited p53(INDUCES) 22493095 2 1 0 -Elk1 ELK1 DNA-binding; Transcription factor A4GTP4 314436 Xq11 rat K253-sm 3982501 EVKVEGPkEELEVTE apoptosis, inhibited; transcription, inhibited 30849179 3 1 0 GADD45A expression; APP/PS1 rats -Tal1 TAL1 DNA-binding; Oncoprotein; Transcription factor P22091 21349 4 D1|4 52.73 cM mouse S172-p 4704529 NRVKRRPsPYEMEIS molecular association, regulation DNA(DISRUPTS) 9111058 2 2 1 -WASL N-WASP Adaptor/scaffold; Motility/polarity/chemotaxis O00401 8976 7q31.32 human S484-p 3149548 KRSKAIHsSDEDEDE activity, induced; molecular association, regulation; intracellular localization; phosphorylation cell motility, induced; cytoskeletal reorganization PAK4(INDUCES) 21097841; 21898535; 29100370 4 19 2 -CACYBP CACYBP Adaptor/scaffold; Ubiquitin conjugating system Q9HB71 27101 1q25.1 human K14-ub 22241672 QKDLEEVkVLLEKAT Siah-Interact_N apoptosis, induced; autophagy, inhibited 31213539 1 4 0 on DNA damage -KIF20A KIF20A Microtubule-binding; Motor O95235 10112 5q31.2 human S532-p 459833 KEHSLQVsPSLEKGA molecular association, regulation; intracellular localization; protein conformation cell cycle regulation AurB(DISRUPTS); INCENP(DISRUPTS) 24656812 1 30 0 favours solubility, inhibits microtubule binding -SKA3 SKA3 Cell cycle regulation Q8IX90 221150 13q12.11 human T358-p 459962 SYENLLRtPTPPEVT molecular association, regulation; intracellular localization cell cycle regulation; chromatin organization, altered; cytoskeletal reorganization HEC1(INDUCES) 28479321; 32491969 2 6 6 -YWHAZ 14-3-3 zeta Adaptor/scaffold; Motility/polarity/chemotaxis P63104 7534 8q22.3 human K49-ac 474726 NLLSVAYkNVVGARR 14-3-3 molecular association, regulation apoptosis, induced KIF11(DISRUPTS); ATG9A(DISRUPTS); AS160(DISRUPTS); BAD(DISRUPTS) 25770209 1 6 15 -Atxn1 ataxin-1 Nuclear export; RNA-binding P54254 20238 13 A5|13 21.98 cM mouse S751-p 449110 ATRKRRWsAPETRKL protein stabilization; molecular association, regulation; intracellular localization; phosphorylation apoptosis, altered; transcription, altered 14-3-3 epsilon(INDUCES) 20869591; 21835928; 29860311; 33554954 19 28 3 -PLAGL2 PLAGL2 C2H2-type zinc finger protein; DNA-binding Q9UPG8 5326 20q11.21 human K269-ac 483053 CSSTVSVkEELSPVL sumoylation transcription, induced 17551969 1 0 0 acetylation abolishes sumoylation on the same three residues, promoter-specific transcription -Aurkb AurB EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, Other; Protein kinase, Ser/Thr (non-receptor) O70126 20877 11 B3|11 42.32 cM mouse K207-ub 21129738 KVIHRDIkPENLLLG Pkinase protein degradation cell cycle regulation; carcinogenesis, inhibited; apoptosis, induced 23928698 2 4 0 -GATA3 GATA3 Transcription factor P23771 2625 10p14 human K292-ac 460636 NACGLYHkMNGQNRP GATA intracellular localization cell growth, inhibited; transcription, induced 10970860 1 0 0 regulated survival after activation, regulates T-cell trafficking to secondary -Gria2 GluR2 Channel, calcium; Channel, ligand-gated; Membrane protein, integral; Membrane protein, multi-pass P23819 14800 3 E3|3 35.5 cM mouse S880-p 448351 YNVYGIEsVKI____ receptor internalization, induced; receptor internalization, altered neural plasticity; endocytosis, induced 19279258; 31969804; 32071234; 35710984; 37626185 30 1 0 -CAMK2A CAMK2A iso2 EC 2.7.11.17; KINASE; Kinase, protein; Protein kinase, CAMK; Protein kinase, Ser/Thr (non-receptor) Q9UQM7-2 815 5q32 human T305-p 448802 KLKGAILtTMLATRN molecular association, regulation; intracellular localization; enzymatic activity, inhibited; phosphorylation NMDAR2B(DISRUPTS) 28636948 24 5 1 inhibits phosphorylation at T286, regulates LTP, fear memory, spatial learning -AATF AATF Nucleolus; RNA-binding; Transcription factor Q9NY61 26574 17q12 human S320-p 460426 NAGSEEIsSEDDELV AATF-Che1 acetylation chromatin organization, altered; cell growth, induced; transcription, induced H3(INDUCES) 34266450 1 53 7 induces histone acetylation -DRD1 DRD1 GPCR, family 1; Membrane protein, integral; Membrane protein, multi-pass; Receptor, GPCR P21728 1812 5q35.2 human S258-p 455302 VECSQPEsSFKMSFK 7tm_1 molecular association, regulation signaling pathway regulation G-alpha(s)(DISRUPTS); ARR3(INDUCES) 32503917 2 0 0 ERK1/2 activation -RPS6KB1 p70S6K EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, AGC; Protein kinase, Ser/Thr (non-receptor); Translation P23443 6198 17q23.1 human T412-p 448607 NQVFLGFtYVAPSVL Pkinase_C activity, induced; molecular association, regulation; intracellular localization; phosphorylation; enzymatic activity, induced cell cycle regulation; carcinogenesis, induced; carcinogenesis, inhibited; cell motility, induced; cell growth, inhibited; transcription, induced; signaling pathway regulation; translation, altered; autophagy, induced; cell growth, induced; apoptosis, inhibited; autophagy, inhibited; cell adhesion, altered; translation, induced; translation, inhibited ELF4(DISRUPTS); ELF3(INDUCES) 11684675; 12036952; 12609989; 12807916; 12970779; 14660640; 15028555; 15304500; 17347671; 17446865; 17936702; 19079619; 20599721; 21394080; 21602892; 21734039; 21986499; 24396066; 24954509; 25738361; 31802035; 33658337; 34336098; 34518212; 34546793; 34673774; 34737445; 35015571; 35077510; 35288456; 36357572; 36787291; 37507012; 7489717; 7545671; 9218810 476 9 1 -CENPC CENPC1 Q03188 1060 4q13.2 human T734-p 14571365 KLVLPSNtPNVRRTK molecular association, regulation; intracellular localization cell cycle regulation CENPT(INDUCES); CENPA(INDUCES) 31676716 1 20 7 -SMN1 SMN RNA processing; RNA-binding Q16637 6606 5q13.2 human S49-p 1873529903 AYDKAVAsFKHALKN SMN molecular association, regulation; protein conformation cell growth, induced SMN(INDUCES) 34161763 1 1 0 -ELK4 ELK4 DNA-binding; Transcription, coactivator/corepressor P28324 2005 1q32.1 human K167-sm 25352009 VKLFKLIkTENPAEK transcription, inhibited 20637912 1 1 0 -TP53 p53 Activator; DNA-binding; Motility/polarity/chemotaxis; Nuclear receptor co-regulator; Transcription factor; Tumor suppressor P04637 7157 17p13.1 human K370-m1 2574935 RAHSSHLkSKKGQST molecular association, regulation; protein conformation; activity, inhibited carcinogenesis, inhibited; transcription, induced; transcription, inhibited JMJD2A(INDUCES); 53BP1(INDUCES) DNA(DISRUPTS) 17108971; 17805299; 19334741; 27535933; 31069954 5 3 0 -SFRP4 SFRP4 Secreted; Secreted, signal peptide Q6FHJ7 6424 7p14.1 human T189-p 50799492 KVKPTLAtYLSKNYS NTR molecular association, regulation carcinogenesis, induced; transcription, induced; signaling pathway regulation CTNNB1(INDUCES) 31390565 1 1 0 induces B-catenin transcriptional activity and CD133 expression, regulates Wnt/B-catenin signaling pathway -RNF187 RNF187 EC 6.3.2.-; EC 6.3.2.19; UBIQUITIN LIGASE; Ubiquitin conjugating system; Ubiquitin ligase Q5TA31 149603 1q42.13 human R98-me 347475300 AALQLLCrADAGPLC protein stabilization; molecular association, regulation; protein conformation transcription, induced Jun(INDUCES) 23624934 1 1 0 dimerisation, expression of Jun target genes -HSP90AB1 HSP90B Chaperone; Heat shock protein P08238 3326 6p21.1 human Y301-p 462282 DDITQEEyGEFYKSL HSP90 molecular association, regulation; protein conformation eNOS(INDUCES) 17855507; 23867252 2 3 11 phosphorylation induces altered conformation and governs drug specificity.; promotes NO(2-) release -L1CAM NCAM-L1 Cell adhesion; Membrane protein, integral P32004 3897 Xq28 human Y1229-p 10272401 DGSFIGQySGKKEKE Bravo_FIGEY activity, induced; molecular association, regulation; protein conformation; phosphorylation cytoskeletal reorganization; signaling pathway regulation ANK3(DISRUPTS) 19720049; 31640849 5 0 4 -PKP1 plakophilin 1 Cell adhesion; Motility/polarity/chemotaxis Q13835 5317 1q32.1 human T180-p 27717309 GSKGQKTtQNRYSFY activity, induced; protein stabilization cell motility, induced; cell growth, induced; translation, induced; cell adhesion, inhibited 23444369 1 1 0 -SIRT1 SIRT1 Apoptosis; DEACETYLASE; Deacetylase; EC 3.5.1.-; Nuclear receptor co-regulator Q96EB6 23411 10q21.3 human S682-p 41401500 SDSGTCQsPSLEEPM intracellular localization apoptosis, induced; transcription, induced 26113041 1 0 0 localized to PML-NBs, facilitates efficient p53 acetylation, potentiates apoptotic p53 target gene expression -THRB TR-beta1 DNA-binding; Nuclear receptor P10828 7068 3p24.2 human K50-sm 27490401 SERRSTLkNEQSSPH molecular association, regulation; intracellular localization cell growth, induced; cell differentiation, induced; transcription, induced; signaling pathway regulation; transcription, altered CBP(DISRUPTS); Src(INDUCES); N-CoR1(INDUCES) DNA(INDUCES); DNA(DISRUPTS) 22930759; 25572392; 27843805 4 0 0 -Wasf1 WAVE1 Cytoskeletal; Motility/polarity/chemotaxis Q5BJU7 rat S397-p 7979603 APPLVQPsPPVARAA intracellular localization cytoskeletal reorganization 19460862 4 2 0 -Nfya NFYA DNA-binding; Transcription factor P23708 18044 17 C|17 23.99 cM mouse K289-ac 4659501 AKLEAEGkIPKERRK CBFB_NFYA cell growth, induced; transcription, induced 18815279 1 1 0 -TCF3 E2A Cell development/differentiation; DNA-binding; Oncoprotein; Transcription factor P15923 6929 19p13.3 human T355-p 455166 NFSSSPStPVGSPQG activity, inhibited transcription, inhibited 19801649 3 4 25 -NDC80 HEC1 Cell cycle regulation O14777 10403 18p11.32 human S15-p 474511 SGGAGRLsMQELRSQ cell cycle regulation; cytoskeletal reorganization 17129782; 35878017; 36897279 3 5 0 -SLAMF1 SLAM Membrane protein, integral; Receptor, misc. Q13291 6504 1q23.3 human Y281-p 447633 EKKSLTIyAQVQKPG molecular association, regulation SHP-2(INDUCES); APCS(INDUCES) 11806999 2 9 741 -UHRF1 UHRF1 iso2 DNA-binding; EC 6.3.2.-; EC 6.3.2.19; Ligase; Transcription factor; UBIQUITIN LIGASE; Ubiquitin conjugating system; Ubiquitin ligase Q96T88-2 29128 19p13.3 human S652-p 471011 QQEGGFAsPRTGKGK molecular association, regulation 26299963 3 20 1 S652 phosphorylation showed only a modest (2-fold) reduction of binding affinity, but no direct interaction between S652 and USP7 -NRBF2 NRBF2 Autophagy; Nuclear receptor co-regulator; Transcription, coactivator/corepressor Q96F24 29982 10q21.3 human S120-p 476484 SPLSQKYsPSTEKCL NRBF2 molecular association, regulation; enzymatic activity, inhibited autophagy, induced ULK1(DISRUPTS); beclin 1(DISRUPTS); ATG13(DISRUPTS); ATG14(DISRUPTS); PIK3R4(INDUCES); PIK3C3(INDUCES); RB1CC1(DISRUPTS) 28059666 1 5 0 controls ULK1 complex association and PtdIns3K complex assembly, decreases PtdIns3K lipid kinase activity -UBA52-RPS27A-UBB-UBC ubiquitin Ubiquitin-like modifier P62988 2p16 human K27-ub 3931595 SDTIENVkAKIQDKE ubiquitin protein degradation; protein stabilization; molecular association, regulation; enzymatic activity, induced; phosphorylation; activity, induced; ubiquitination; intracellular localization; protein conformation cell differentiation, inhibited; cell cycle regulation; carcinogenesis, inhibited; cell growth, inhibited; transcription, induced; signaling pathway regulation; DNA repair, induced; autophagy, induced; transcription, inhibited CALCOCO2(INDUCES); SHP-1(DISRUPTS) 15466860; 30631154; 30741923; 31127032; 31304625; 31862882; 32476569; 34362877; 35238669; 35918322; 35982175; 36343628; 36563124 30 23 142 MRE11A promotes its exonuclease activity -SOX2 SOX2 Cell development/differentiation; DNA-binding; Transcription factor P48431 6657 3q26.33 human S251-p 6738002 VKSEASSsPPVVTSS protein stabilization; molecular association, regulation; ubiquitination cell differentiation, inhibited; carcinogenesis, induced; cell growth, induced; apoptosis, inhibited WWP2(DISRUPTS); CUL4A(DISRUPTS) 34193614; 37349645 4 13 0 inhibits ubiquitination -IBTK IBTK Protein kinase, regulatory subunit Q9P2D0 25998 6q14.1 human S1200-p 21358401 ASSLHSVsSKSFRDF activity, induced; molecular association, regulation; intracellular localization; enzymatic activity, induced Btk(DISRUPTS) 21482705 1 1 0 regulation of the Btk:IBTK complex, induce calcium mobilization and NFkB activation -GTF2A1 GTF2A1 Transcription, coactivator/corepressor P52655 2957 14q31.1 human S316-p 448629 VEEEPLNsEDDVSDE TFIIA transcription, induced 11278496 1 6 0 -DUSP6 DUSP6 EC 3.1.3.16; EC 3.1.3.48; Motility/polarity/chemotaxis; PHOSPHATASE; Protein phosphatase, dual-specificity Q16828 1848 12q21.33 human S197-p 455266 SATDSDGsPLSNSQP protein degradation 15632084 5 0 0 -Cacng2 Stargazin Channel, calcium; Membrane protein, integral; Membrane protein, multi-pass O88602 12300 15 E1|15 36.92 cM mouse S239-p 455315 RYQRRSRsSSRSTEP activity, induced; intracellular localization neural plasticity 15664178; 20670832; 24882000 7 0 0 AMPAR immobilization in synaptic membrane; enhances AMPA receptor responses and is required for long-term potentiation; regulates synaptic scaling -KIF11 KIF11 Microtubule-binding; Motor P52732 3832 10q23.33 human Y231-p 14567513 AATLMNAySSRSHSV Kinesin cytoskeletal reorganization 28646493 1 2 1 spindle morphology -MRE11 MRE11A Cell cycle regulation; DNA repair, damage; DNA-binding; Deoxyribonuclease P49959 4361 11q21 human S678-p 460789 SSKIMSQsQVSKGVD protein degradation; molecular association, regulation DNA repair, induced; chromatin organization, altered C1QBP(DISRUPTS); NBS1(INDUCES) DNA(INDUCES); DNA(DISRUPTS) 19709933; 26240375; 31353207 3 6 10 -CD4 CD4 Cell surface; Membrane protein, integral P01730 920 12p13.31 human S440-p 469618 SQIKRLLsEKKTCQC Tcell_CD4_C intracellular localization 15494497 1 0 0 -SUV39H1 SUV39H1 Amino Acid Metabolism - lysine degradation; EC 2.1.1.43; METHYLTRANSFERASE; Methyltransferase; Methyltransferase, protein lysine O43463 6839 Xp11.23 human S391-p 469894 GLAGLPGsPKKRVRI molecular association, regulation cell cycle regulation DNA(DISRUPTS) 24728993 1 40 20 disassociation of SUV39H, leading to H3K9m3 reduction, and heterochromatin replication during cell cycle progression -Runx1 AML1 DNA-binding; Oncoprotein; Transcription factor Q03347 12394 16 C4|16 53.7 cM mouse Y260-p 51211403 SYDQSYQyLGSITSS activity, induced; protein stabilization transcription, induced HDAC1(DISRUPTS) DNA(INDUCES) 26598521 1 0 0 -NINL Nlp Cell cycle regulation; Microtubule-binding Q9Y2I6 22981 20p11.21 human S589-p 17490600 NRHSPSWsPDGRRRQ protein degradation; ubiquitination; intracellular localization 20890132 1 0 0 -GCM1 GCM1 DNA-binding; Transcription factor Q9NP62 8521 6p12.1 human S326-p 7979601 PLTSWPCsFSPSQNS protein degradation; molecular association, regulation; ubiquitination FBXW2(INDUCES) 19416964 1 0 0 -SKI SKI Cell cycle regulation; Oncoprotein; Transcription, coactivator/corepressor; Ubiquitin conjugating system P12755 6497 1p36.33-p36.32 human S326-p 41656200 RRVPRVSsEPPASIR protein degradation cell cycle regulation; carcinogenesis, induced 26138431 1 1 0 plays a role in chromosomal segregation -SLC6A1 SLC6A1 Membrane protein, integral; Membrane protein, multi-pass; Transporter; Transporter, SLC family P30531 6529 3p25.3 human Y317-p 11382800 NSFHNNVyRDSIIVC SNF activity, induced; receptor internalization, altered; intracellular localization 11555659 1 0 0 -CCNT1 CCNT1 Cell cycle regulation; Transcription initiation complex O60563 904 12q13.11-q13.12 human K386-ac 25174700 SKSVPSAkVSLKEYR molecular association, regulation; enzymatic activity, induced transcription, induced BCDIN3(DISRUPTS); HEXIM1(DISRUPTS); BRD4(INDUCES) RNA(DISRUPTS) 19387490; 22084242 3 1 0 Interaction with BRD4 disrupts interaction with HEXIM1 and 7SK snRNA; enhances CDK9/cyclin T1 transcriptional activity, disrupting HEXIM1 and BCDIN3 association -Dok2 DOK2 Adaptor/scaffold O70469 13449 14 D2|14 36.71 cM mouse Y402-p 455779 DWPQATEyDNVILKK molecular association, regulation apoptosis, induced CSK(INDUCES) 15831486 1 0 44 Dok2 constitutively interacts with Src. Induced binding of Csk to Dok2 allows Csk to act on Src. -NOTCH1 Notch 1 Membrane protein, integral; Motility/polarity/chemotaxis; Oncoprotein; Receptor, misc.; Transcription factor P46531 4851 9q34.3 human S2522-p 467288 ESPDQWSsSSPHSNV protein degradation; receptor inactivation, altered 16880534 1 0 0 Alanine mutation of 4 serines (S2522/S2523/S2524/S2525) causes increased protein stability. -ID3 ID3 DNA-binding; Transcription, coactivator/corepressor Q02535 3399 1p36.12 human S5-p 451011 ___MKALsPVRGCYE protein stabilization cell cycle regulation; transcription, altered 25090023; 9372912 2 7 9 Cdk-dependent phosphorylation inactivates the G1-to-S cell cycle regulatory function of Id3 protein.; regulates vascular EC survival and growth of microvascular lesions -SORT1 SORT1 Membrane protein, integral; Receptor, misc. Q99523 6272 1p13.3|1p21.3-p13.1 human S793-p 3823097 RFLVHRYsVLQQHAE molecular association, regulation; intracellular localization AP1AR(DISRUPTS) 31767632 3 8 0 -EPHA3 EphA3 EC 2.7.10.1; KINASE; Kinase, protein; Membrane protein, integral; Protein kinase, TK; Protein kinase, tyrosine (receptor) P29320 2042 3p11.1 human Y596-p 449912 KLPGLRTyVDPHTYE EphA2_TM molecular association, regulation; protein conformation; enzymatic activity, induced cytoskeletal reorganization; cell adhesion, altered CRK(INDUCES) 11870224; 18547520 3 6 26 -AXIN1 axin 1 Adaptor/scaffold; Tumor suppressor O15169 8312 16p13.3 human S469-p 25802104 AHEENPEsILDEHVQ Axin_b-cat_bind transcription, inhibited GSK3B(INDUCES) 17318175 1 3 0 -Rela NFkB-p65 DNA-binding; Nuclear receptor co-regulator; Transcription factor Q04207 19697 19 A|19 4.34 cM mouse T504-p 455490 EAITRLVtGSQRPPD cell motility, inhibited 26853469 4 0 0 higher levels of cell proliferation with T505A mutant mouse -LATS2 LATS2 EC 2.7.11.1; KINASE; Kinase, protein; Nuclear receptor co-regulator; Protein kinase, AGC; Protein kinase, Ser/Thr (non-receptor); Tumor suppressor Q9NRM7 26524 13q12.11 human T436-gl 1869341904 PNTVTAVtAAHILHP molecular association, regulation; enzymatic activity, inhibited; phosphorylation carcinogenesis, induced; cell growth, induced; signaling pathway regulation MOB1B(DISRUPTS) 32513743 1 1 0 inhibits phosphorylation at LATS2-S872 and T1041; disrupts the hippo-pathway -IRF5 IRF5 DNA-binding; Transcription factor Q13568 3663 7q32.1 human Y335-p 25742049 QLQGQDLyAIRLCQC IRF-3 molecular association, regulation; ubiquitination transcription, inhibited LYN(INDUCES) 27521268 1 1 2 inhibition of IRF5 activation by Lyn requires their physical Interaction, Lyn inhibits IRF5 ubiquitination and phosphorylation by protecting IRF5 from each of PTM enzymes -POU3F2 Oct7 DNA-binding; Motility/polarity/chemotaxis; Transcription factor P20265 5454 6q16.1 human S96-p 1868139201 DGSPWSTsPLGQPDI DNA repair, altered; signaling pathway regulation DNA(INDUCES) 30804224 1 0 0 -Traf3 TRAF3 UBIQUITIN LIGASE; Ubiquitin conjugating system; Ubiquitin ligase Q60803 22031 12 F1|12 60.94 cM mouse S29-p 23154950 QPDRGAGsVLVPEQG cell growth, induced; apoptosis, inhibited; transcription, induced; signaling pathway regulation 34255829 1 2 2 induces NIK stabilization and NF-kB signaling -CALU CALU iso15 Calcium-binding; Secreted; Secreted, signal peptide O43852-15 813 7q32.1 human T73-p 29606705 MYSHDGNtDEPEWVK intracellular localization transcription, induced; cytoskeletal reorganization 24136234 1 0 0 nuclear localization, facilitates filopodia formation -VPS4A VPS4A EC 3.6.4.6; Vesicle Q9UN37 27183 16q22.1 human K23-ub 1881849300 ATEEDKAkNYEEALR molecular association, regulation; ubiquitination; enzymatic activity, induced CHMP1B(INDUCES) 35044214 1 0 0 interaction after HCV infection, enhances VPS4A ATPase activity, release of HCV particles -AQP4 AQP4 Channel, misc.; Membrane protein, integral; Membrane protein, multi-pass; Transporter; Transporter, aquaporin family P55087 361 18q11.2 human S180-p 467301 TIFASCDsKRTDVTG MIP activity, inhibited cell motility, altered 19761816 4 0 0 mutation of this site (S180A) increases invasion of tumor cells; reduces water permeability -APLNR APLNR GPCR, family 1; Membrane protein, integral; Membrane protein, multi-pass; Receptor, GPCR P35414 187 11q12.1 human S339-p 1870435803 AGTSHSSsGEKSASY activity, induced; receptor internalization, induced; molecular association, regulation GRK2(DISRUPTS) 32863206 0 1 0 ERK1/2 activation -LIN28A LIN28A Nucleolus; RNA-binding; Translation Q9H9Z2 79727 1p36.11 human K15-sm 1877427002 QFAGGCAkAAEEAPE molecular association, regulation carcinogenesis, induced; cell motility, induced; cell growth, induced 32333719 1 0 0 binding affinity to pre-let-7, suppresses let-7 miRNA biogenesis -TP73 p73 DNA-binding; Transcription factor; Tumor suppressor O15350 7161 1p36.32 human S235-p 23481800 DPVTGRQsVVVPYEP P53 molecular association, regulation; intracellular localization cell cycle regulation; cell growth, induced; apoptosis, inhibited; transcription, inhibited CDC20(DISRUPTS); HSPA9B(INDUCES) DNA(DISRUPTS) 22340593 1 0 0 -PRNP PRNP Membrane protein, GPI anchor; Microtubule-binding P04156 5621 20p13 human Y145-p 38520206 IIHFGSDyEDRYYRE Prion protein conformation 25572400 1 0 0 exacerbate PRNP mutant conversion -CYP2E1 CYP2E1 EC 1.14.13.n7; Endoplasmic reticulum; Lipid Metabolism - arachidonic acid; Lipid Metabolism - linoleic acid; Mitochondrial; Oxidoreductase; Xenobiotic Metabolism - drug metabolism - cytochrome P450; Xenobiotic Metabolism - metabolism by cytochrome P450 P05181 1571 10q26.3 human R379-me 1878196104 ATRDTIFrGYLIPKG protein degradation 31077594 1 1 0 me-CYP2E1 is reduced in Mat1a KO liver mitochondria; down-regulation of CYP2E1 protein level requires R379 methylation -Rb1 Rb Nuclear receptor co-regulator; Oncoprotein; Transcription, coactivator/corepressor; Tumor suppressor P33568 24708 15q11 rat S787-p 447979 SPYKFSSsPLRIPGG Rb_C molecular association, regulation transcription, inhibited HDAC1(INDUCES) 19081374 52 17 94 -LLGL1 LLGL1 Cell adhesion; Cytoskeletal; Motility/polarity/chemotaxis Q15334 3996 17p11.2 human S655-p 449915 GPLSRVKsLKKSLRQ intracellular localization 34717957 2 1 4 -EMD emerin Cytoskeletal; Membrane protein, integral P50402 2010 Xq28 human Y161-p 449652 MYGRDSAyQSITHYR molecular association, regulation BAF(INDUCES) 19789182 1 12 257 -APOBEC3B APOBEC3B EC 3.5.4.-; Hydrolase; RNA-binding Q9UH17 9582 22q13.1 human T214-p 1869951800 LVLRRRQtYLCYEVE NAD2 enzymatic activity, inhibited carcinogenesis, altered DNA(DISRUPTS) 31165764 1 0 0 regulates anti-retroviral and anti-retrotransposition activity -MELK MELK EC 2.7.10.2; EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, CAMK; Protein kinase, Ser/Thr (non-receptor); Protein kinase, tyrosine (non-receptor); RNA splicing Q14680 9833 9p13.2 human T167-p 456039 NKDYHLQtCCGSLAY Pkinase enzymatic activity, induced 16216881 3 1 0 -IRF1 IRF1 Transcription factor; Tumor suppressor P10914 3659 5q31.1 human K78-ub 31914114 EPDPKTWkANFRCAM IRF protein degradation; molecular association, regulation DNA(DISRUPTS) 23134341 1 3 0 -CDK11B CDK11B iso12 Apoptosis; Cell cycle regulation; EC 2.7.11.22; KINASE; Kinase, protein; Motility/polarity/chemotaxis; Protein kinase, CMGC; Protein kinase, Ser/Thr (non-receptor) P21127-12 984 1p36.33 human T370-p 17671300 KHEYFREtPLPIDPS molecular association, regulation; enzymatic activity, induced apoptosis, altered CDK11A iso10(INDUCES) 21078675 1 1 0 T370A mutant fails to repress the transactivation of androgen receptor and to enhance the cell apoptosis -PSMC5 RPT6 Nuclear receptor co-regulator; Proteasome complex; Ubiquitin conjugating system P62195 5705 17q23.3 human S120-p 483970 RVALRNDsYTLHKIL Prot_ATP_ID_OB activity, induced; molecular association, regulation 17565987; 23275441 11 7 0 proteosome activity enhanced,delays formation HTT aggregates; S120A mutation blocks proteasome function in vivo -Rela NFkB-p65 DNA-binding; Nuclear receptor co-regulator; Transcription factor Q7TQN4 309165 1q43 rat S276-p 447798 SMQLRRPsDRELSEP RHD_dimer cell differentiation, altered; apoptosis, inhibited; transcription, induced 18385332; 21550382 90 0 0 induces cell survival; nerve myelination -PRKCD PKCD EC 2.7.11.13; KINASE; Kinase, protein; Nuclear receptor co-regulator; Protein kinase, AGC; Protein kinase, Ser/Thr (non-receptor); Protein kinase, tyrosine (non-receptor); Tumor suppressor Q05655 5580 3p21.1 human Y313-p 447573 SSEPVGIyQGFEKKT sumoylation; molecular association, regulation; protein conformation; enzymatic activity, altered; phosphorylation carcinogenesis, induced; apoptosis, altered; cell motility, induced; cell growth, induced; signaling pathway regulation; transcription, inhibited 16982614; 17126298; 21730054; 24260357; 25755284; 26876198; 34089566; 36862682 44 60 1707 -CDK5R1 CDK5R1 Protein kinase, regulatory subunit Q15078 8851 17q11.2 human S91-p 12607404 ENLKKSLsCANLSTF CDK5_activator protein degradation; molecular association, regulation; ubiquitination PJA2(INDUCES) 24561619 4 0 0 regulates calcium entry in the Beta-cell and insulin secretion -AR AR DNA-binding; Nuclear receptor; Transcription factor P10275 367 Xq12 human Y269-p 478250 QLRGDCMyAPLLGVP Androgen_recep acetylation; molecular association, regulation; intracellular localization carcinogenesis, induced; cell growth, induced; transcription, induced; cell growth, altered p300(INDUCES) DNA(INDUCES) 17494760; 20623637; 25950519; 28055971; 35704598 7 2 0 primes acetylation at K610 -PDGFRB PDGFRB EC 2.7.10.1; KINASE; Kinase, protein; Membrane protein, integral; Oncoprotein; Protein kinase, TK; Protein kinase, tyrosine (receptor) P09619 5159 5q32 human Y740-p 447520 TGESDGGyMDMSKDE PK_Tyr_Ser-Thr activity, induced; molecular association, regulation; enzymatic activity, induced cell cycle regulation PIK3C2A(INDUCES); SHC1(INDUCES); SHP-1(INDUCES); PIK3R1(INDUCES); PIK3CA(INDUCES) 1314164; 1375321; 17403678; 7774014; 7935391; 8195171; 8290276; 9452499 11 2 7 -RPS6KA4 MSK2 EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, AGC; Protein kinase, Ser/Thr (non-receptor) O75676 8986 11q13.1 human T568-p 450047 SPGVPMQtPCFTLQY Pkinase enzymatic activity, induced 10806207 1 0 0 -RBBP8 CtIP EC 3.1.-.-; Transcription, coactivator/corepressor Q99708 5932 18q11.2 human S327-p 452473 ELPTRVSsPVFGATS molecular association, regulation; phosphorylation cell cycle regulation BRCA1(DISRUPTS); PLK1(INDUCES); BRCA1(INDUCES) 15485915; 16101277; 30202980 6 22 1 stimulates binding of CtIP to PBD domain of PLK1 and its further phosphorylation by PLK1 at S723; Phosphorylation required for G2/M transition checkpoint. -SERPINF1 PEDF Inhibitor; Secreted; Secreted, signal peptide P36955 5176 17p13.3 human S227-p 455233 KFDSRKTsLEDFYLD Serpin molecular association, regulation apoptosis, altered; carcinogenesis, altered; cell motility, altered LEPR(INDUCES) 21059648 3 1 0 -CEBPB C/EBP-beta DNA-binding; Motility/polarity/chemotaxis; Transcription factor P17676 1051 20q13.13 human K264-ac 458939 SQVKSKAkKTVDKHS molecular association, regulation transcription, inhibited DNA(DISRUPTS) 12574125 4 0 0 -Nfatc2 NFAT1 DNA-binding; Transcription factor Q60591 18019 2 H3|2 88.91 cM mouse S99-p 447854 IGFQNFLsPVKPAGA transcription, inhibited 11030334 0 3 1 -EIF4G3 EIF4G3 RNA-binding; Translation; Translation initiation O43432 8672 1p36.12 human S1156-p 2915400 NTFMRGGsSKDLLDN molecular association, regulation translation, induced EIF4E(INDUCES) 22514323 2 13 0 -MAP2K1 MEK1 EC 2.7.12.2; KINASE; Kinase, protein; Protein kinase, STE; Protein kinase, dual-specificity (non-receptor) Q02750 5604 15q22.31 human S222-p 448513 LIDSMANsFVGTRSY Pkinase intracellular localization; protein conformation; phosphorylation; enzymatic activity, induced cell cycle regulation; carcinogenesis, induced; cell growth, induced; transcription, induced; signaling pathway regulation; cell growth, altered 12466969; 12506122; 12609989; 16585161; 17667937; 19106095; 21893193; 24681949; 27323830; 32076487; 33789117; 33808483; 34470822; 34642304; 7731726; 8621729 117 20 203 -FLOT1 FLOT1 Adaptor/scaffold O75955 10211 6p21.33 human Y160-p 462262 DIHDDQDyLHSLGKA Band_7 endocytosis, altered 19258392 1 3 48 regulates FLOT1 internalization -Shisa7 SHISA7 Membrane protein, integral Q8C3Q5 232813 7|7 A1 mouse S405-p 3989799 PNPRRVMsQEHLLGD intracellular localization neural plasticity; exocytosis, induced 33761345; 35534528 2 1 5 -ERBB3 HER3 EC 2.7.10.1; KINASE; Kinase, protein; Membrane protein, integral; Oncoprotein; Protein kinase, TK; Protein kinase, tyrosine (receptor) P21860 2065 12q13.2 human Y1276-p 449857 GGGPGGDyAAMGACP molecular association, regulation carcinogenesis, induced; cell motility, induced PIK3R2(INDUCES); PIK3R1(INDUCES) 16729043; 21725367 3 6 57 chemotaxis and invasion -PPARA PPAR-alpha DNA-binding; Nuclear receptor; UBIQUITIN LIGASE Q07869 5465 22q13.31 human S6-p 1789804 __MVDTEsPLCPLSP transcription, inhibited 18079279; 21224484 2 0 0 -HRH1 H1R GPCR, family 1; Membrane protein, integral; Membrane protein, multi-pass; Receptor, GPCR P35367 3269 3p25.3 human T140-p 453406 LRYLKYRtKTRASAT 7tm_1 receptor desensitization, altered; receptor internalization, altered 15107581; 15328002 2 0 0 -Nos1 nNOS Amino Acid Metabolism - arginine and proline; EC 1.14.13.39; Oxidoreductase P29476 24598 12q16 rat S293-p 56689901 QSPTKNGsPSRCPRF protein conformation 27296112 1 0 0 may disrupt the formation of nNOS dimers -IRF1 IRF1 Transcription factor; Tumor suppressor P10914 3659 5q31.1 human S215-p 31839602 DLYNFQVsPMPSTSE molecular association, regulation; activity, inhibited transcription, inhibited NFkB-p65(DISRUPTS) 24396068 1 0 0 Phosphorylation impairs iNFkB-p65 interaction and PCAF mediated acetylation K310 -suppression of IFN-beta production -PKM PKM Carbohydrate Metabolism - glycolysis and gluconeogenesis; Carbohydrate Metabolism - pyruvate; EC 2.7.1.40; KINASE; Kinase, other; Mitochondrial; Nucleotide Metabolism - purine P14618 5315 15q23 human S362-gl 1879953200 GADCIMLsGETAKGD enzymatic activity, inhibited cell growth, induced PKM(DISRUPTS) 31501520 1 0 0 O-GlcNAcylation of PKM inhibits its catalytic activity and tetramerization -Srpk1 SRPK1 EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, CMGC; Protein kinase, Ser/Thr (non-receptor) O70551 20815 17|17 A3.3 mouse S51-p 456012 QEEEILGsDDDEQED chromatin organization, altered 36765089 2 49 23 -NCOA2 SRC-2 Motility/polarity/chemotaxis; Nuclear receptor co-regulator; Transcription, coactivator/corepressor Q15596 10499 8q13.3 human K780-ac 466316 TDPASNTkLIAMKTE DUF4927 activity, inhibited transcription, inhibited; signaling pathway regulation 31851938 1 7 41 PPAR-gamma inhibition -USP14 USP14 DEUBIQUITINASE; EC 3.4.19.12; Protease; Ubiquitin conjugating system; Ubiquitin-specific protease P54578 9097 18p11.32 human S432-p 31083558 THQGRSSsSGHYVSW UCH protein degradation; ubiquitination 26523394 1 1 0 regulate the UPS in a ubiquitin-dependent manner, regulate global 273 protein degradation -Wnk4 WNK4 EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, Other; Protein kinase, Ser/Thr (non-receptor) Q80UE6 69847 11|11 D mouse K154-ub 40323309 RRREQEEkEDTETQA protein degradation 23576762 1 1 0 regulates electrolyte homeostasis and involved in Pseudohypoaldosteronism type II (PHAII) pathogenesis -NR1H2 LXR-beta Nuclear receptor P55055 7376 19q13.33 human K409-sm 12004410 LLSYTRIkRPQDQLR Hormone_recep molecular association, regulation transcription, inhibited coronin 2A(INDUCES) DNA(INDUCES) 17218271; 21331046 2 0 0 -PRKAA1 AMPKA1 Autophagy; EC 2.7.11.1; EC 2.7.11.26; EC 2.7.11.27; EC 2.7.11.31; KINASE; Kinase, protein; Protein kinase, CAMK; Protein kinase, Ser/Thr (non-receptor) Q13131 5562 5p13.1 human T183-p 448786 SDGEFLRtSCGSPNY Pkinase intracellular localization; phosphorylation; enzymatic activity, induced cell differentiation, inhibited; cell cycle regulation; carcinogenesis, induced; cell growth, inhibited; apoptosis, induced; transcription, induced; signaling pathway regulation; autophagy, induced; apoptosis, inhibited 12391032; 14511394; 14614828; 14985505; 15980064; 17082196; 19414597; 19884317; 21918180; 22039048; 26771234; 27864418; 28778925; 30022161; 30309849; 30413706; 34807950; 35413286; 35670018 228 16 33 -MCL1 MCL1 Apoptosis; Channel, misc.; Inhibitor; Membrane protein, integral; Mitochondrial Q07820 4170 1q21.2 human K40-ac 1875365200 GRLLATEkEASARRE protein stabilization; molecular association, regulation; ubiquitination carcinogenesis, induced; cell growth, induced; apoptosis, inhibited USP9X(INDUCES) 34758305 1 1 0 acetylation decreases ubiquitination; phosphorylation impairs interaction with USPX and increases poly ubiquitination -Syn1 SYN1 Vesicle O88935 20964 X A1.3|X 16.37 cM mouse S551-p 451574 PAARPPAsPSPQRQA cytoskeletal reorganization; signaling pathway regulation 25463523; 30016727 10 18 10 protects against ischemic injury and cell death; OGD induces morphological damage of neurites in cortical neurons; multiple signaling pathways converge onto SynI and regulated by phosphorylation, hippocampal-dependent learning de?cits -TPPP TPPP Cytoskeletal O94811 11076 5p15.33 human S18-p 456612 ANRTPPKsPGDPSKD cytoskeletal reorganization 17693641 1 25 9 ERK2 phosphorylation of TPPP induces formation of tubulin assemblies. -RAD9A RAD9A Apoptosis; Cell cycle regulation; DNA replication; Deoxyribonuclease; EC 3.1.11.2 Q99638 5883 11q13.2 human S341-p 449817 PKSPGPHsEEEDEAE molecular association, regulation; intracellular localization TOPBP1(INDUCES) 20545769; 25091155; 26088138 5 7 7 -NCOA3 SRC-3 ACETYLTRANSFERASE; Acetyltransferase; EC 2.3.1.48; Motility/polarity/chemotaxis; Nuclear receptor co-regulator; Transcription, coactivator/corepressor Q9Y6Q9 8202 20q13.12 human T1064-p 4252807 LHTLLSNtDATGLEE Nuc_rec_co-act protein stabilization; molecular association, regulation PSMA3(DISRUPTS) 18313384 1 0 0 some subset of these 8 residues -SSTR5 SSTR5 Cell cycle regulation; GPCR, family 1; Membrane protein, integral; Membrane protein, multi-pass; Receptor, GPCR P35346 6755 16p13.3 human S242-p 1779801 VGCVRRRsERKVTRM 7tm_1 activity, induced; molecular association, regulation; receptor internalization, altered ARRB2(INDUCES) 18096696 1 0 0 -PAK1 PAK1 EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, STE; Protein kinase, Ser/Thr (non-receptor) Q13153 5058 11q13.5-q14.1 human S204-p 448173 TKSVYTRsVIEPLPV molecular association, regulation; intracellular localization; protein conformation; phosphorylation; enzymatic activity, induced carcinogenesis, induced; cell motility, induced; cell growth, induced; cell motility, altered; cell adhesion, altered; signaling pathway regulation PXN(DISRUPTS) 19574218; 30664689; 31660987 18 16 0 phosphorylation of NFkB (activation); Inhibitors decreased the tumor growth by inhibiting the phosphorylation; recruitment to the plasma membrane -MDM2 MDM2 EC 6.3.2.-; EC 6.3.2.19; Inhibitor; Ligase; NEDDYLATION LIGASE; Neddylation Ligase; Nucleolus; Oncoprotein; UBIQUITIN LIGASE; Ubiquitin conjugating system; Ubiquitin ligase Q00987 4193 12q15 human S246-p 454925 DSVSDQFsVEFEVES activity, induced 12167711 3 0 0 promotes p53 degradation -Nedd4l NEDD4L EC 6.3.2.-; EC 6.3.2.19; Ligase; UBIQUITIN LIGASE; Ubiquitin conjugating system; Ubiquitin ligase Q8CFI0 83814 18|18 E1 mouse S477-p 453440 IRRPRSLsSPTVTLS protein stabilization; molecular association, regulation; ubiquitination; intracellular localization 14-3-3 beta(INDUCES); 14-3-3 epsilon(INDUCES); CFTR(DISRUPTS) 16613846; 21900244; 25384981 16 64 53 regulates intracellular localization, prevents ubiquitination and degradation of CFTR -Stat5b STAT5B DNA-binding; Oncoprotein; Transcription factor P42232 20851 11 D|11 63.63 cM mouse Y699-p 448198 TAKAADGyVKPQIKQ activity, induced carcinogenesis, induced; transcription, induced; transcription, altered; cell growth, altered 10706883; 12091337; 34535769 45 45 2242 -Homer3 HOMER3 Adaptor/scaffold Q99JP6 26558 8|8 B3.3 mouse S159-p 477736 EKLFRSQsADTPGPT molecular association, regulation GluR5(DISRUPTS) 26670047 1 31 42 circuit hyperexcitability in fragile X syndrome -Tbk1 TBK1 EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, Other; Protein kinase, Ser/Thr (non-receptor) Q9WUN2 56480 10|10 D2 mouse K30-ub 31033007 VFRGRHKkTGDLYAV Pkinase autophagy, induced 33164878 3 1 0 Parkin mediated mitophagy -Cnr1 CNR1 GPCR, family 1; Membrane protein, integral; Membrane protein, multi-pass; Receptor, GPCR P47746 12801 4 A5|4 16.28 cM mouse T466-p 22342306 KVTMSVStDTSAEAL receptor desensitization, induced 22014214 1 0 1 -Stat3 STAT3 DNA-binding; Motility/polarity/chemotaxis; Nuclear receptor co-regulator; Transcription factor P42227 20848 11 D|11 63.82 cM mouse R31-me 15343402 DSFPMELrQFLAPWI STAT_int phosphorylation signaling pathway regulation 20798359 1 0 0 decrease in STAT3 phosphorylation, regulates Leptin signaling and energy homeostasis -SMAD3 SMAD3 DNA-binding; Nuclear receptor co-regulator; Transcription factor P84022 4088 15q22.33 human K333-ac 1876739200 WHPATVCkIPPGCNL MH2 transcription, induced 32305562 2 0 0 -APP APP iso4 Apoptosis; Cell surface; Membrane protein, integral; Receptor, misc.; Transcription factor P05067-4 351 21q21.3 human S675-p 1869465803 TPEERHLsKMQQNGY APP_amyloid protein processing 31604820 1 0 0 -DNMT1 DNMT1 Amino Acid Metabolism - cysteine and methionine; Cell development/differentiation; EC 2.1.1.37; METHYLTRANSFERASE; Methyltransferase; Methyltransferase, DNA; Transcription regulation P26358 1786 19p13.2 human K749-ac 25171013 GKKSYYKkVCIDAET cell cycle regulation 21947282 1 1 0 -Ncf1 p47phox EC 1.-.-.-; Oxidoreductase F1M707 114553 12q12 rat S316-p 451725 AQSIHQRsRKRLSQD NECFESHC neural plasticity 30181899 14 0 0 phosphorylation is required for LTD synaptic plasticity -IRS4 IRS4 Adaptor/scaffold O14654 8471 Xq22.3 human Y828-p 456293 GQNDNSEyVPMLPGK cell cycle regulation; carcinogenesis, induced; cell growth, induced 35550247 1 4 24 -DSP Desmoplakin Cell adhesion; Cytoskeletal; Motility/polarity/chemotaxis P15924 1832 6p24.3 human R2834-me 34833301 SGSRSGSrSGSRSGS molecular association, regulation cell adhesion, induced 25733715 1 1 0 recruitment into desmosomes, R2834H mutant impaired recruitment and ablated phosphorylation of six serine residues within the GSK3 cascades. facilitates GSK3 interactions with Desmoplakin -TBK1 TBK1 EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, Other; Protein kinase, Ser/Thr (non-receptor) Q9UHD2 29110 12q14.2 human K401-ub 31033006 YEKISLPkVHPRYDL TBK1_CCD1 ubiquitination; intracellular localization; phosphorylation; enzymatic activity, induced transcription, induced; signaling pathway regulation 23453972; 27538435 3 1 0 ubquitination of one of these sites is required for S172 phosphorylation ; TBK1 trans-autophosphorylation phosphorylation at S172, enhances TBK1-induced phosphorylation of IRF3, regulation of downstream-signaling in innate immunity after RNA virus infection -RGS2 RGS2 GAP; GAP, RGS P41220 5997 1q31.2 human S46-p 10772900 KDWKTRLsYFLQNSS activity, induced; molecular association, regulation; intracellular localization G-alpha i3(INDUCES) 14608379; 24777815 2 0 0 RGS2 phosphorylation increases G-alpha GTPase activity, and association with membrane fraction. ; inhibits CPA-induced hydrolysis -Prkce PKCE EC 2.7.11.13; KINASE; Kinase, protein; Protein kinase, AGC; Protein kinase, Ser/Thr (non-receptor) P09216 29340 6q12 rat S729-p 448789 QEEFKGFsYFGEDLM Pkinase_C intracellular localization; enzymatic activity, induced 15886222 20 17 7 -TRIM32 TRIM32 EC 6.3.2.-; EC 6.3.2.19; Ligase; UBIQUITIN LIGASE; Ubiquitin conjugating system; Ubiquitin ligase Q13049 22954 9q33.1 human Y528-p 1876282804 CDAEGTVyFTQGLGL molecular association, regulation carcinogenesis, induced; cell growth, induced; transcription, induced STAT3(INDUCES) 35091679 1 0 0 binding to STAT3 inhibits STAT3-TC45 binding thus inducing STAT3 phosphorylation -FUS hnRNP P2 DNA-binding; Nuclear receptor co-regulator; Oncoprotein; RNA splicing; RNA-binding; SUMO LIGASE P35637 2521 16p11.2 human T68-p 179463704 SQNTGYGtQSTPQGY molecular association, regulation 28942918 2 1 0 strongly reduced the effects of DNA-PK treatment on both hydrogel binding and droplet formation -Cacng2 Stargazin Channel, calcium; Membrane protein, integral; Membrane protein, multi-pass O88602 12300 15 E1|15 36.92 cM mouse Y229-p 11025597 AITRIPSyRYRYQRR molecular association, regulation ARC(DISRUPTS) 25864631 1 0 1 -PAX3/FOXO1 PAX3-FOXO1 AAC50053 2308 13q14.11 human S503-p 37038800 PRTSSNAsTISGRLS protein stabilization cell growth, induced 25398439 1 1 0 -H3C1 H3 DNA-binding P68431 8350 6p22.2 human K122-ac 3652700 KRVTIMPkDIQLARR Histone molecular association, regulation chromatin organization, altered polybromo 1(INDUCES); SMAD4(INDUCES); SMAD2(INDUCES); SMAD3(INDUCES) DNA(DISRUPTS) 19520870; 20368734; 31815277 4 7 3 acetylation facilitates nucleosome repositioning; varying site specificity binding for each bromodomain 1-6 -Ikzf1 Ikaros C2H2-type zinc finger protein; DNA-binding; Transcription factor Q03267 22778 11 A1|11 7.02 cM mouse K58-sm 3609102 RGMGSNVkVETQSDE molecular association, regulation transcription, induced SIN3A(DISRUPTS); SIN3B(DISRUPTS); CHD-4(DISRUPTS); CTBP1(DISRUPTS) 15767674 2 0 0 -DAZAP1 DAZAP1 Motility/polarity/chemotaxis; RNA-binding Q96EP5 26528 19p13.3 human K150-ac 25171021 VMIYDAEkQRPRGFG RRM_1 intracellular localization 22001406 1 0 0 -LMNA lamin A/C Cytoskeletal P02545 4000 1q22 human Y45-p 55369404 LNDRLAVyIDRVRSL Filament molecular association, regulation; intracellular localization chromatin organization, altered; cell motility, induced; DNA repair, inhibited lamin A/C(DISRUPTS) 34385357 1 3 0 -CSNK2A1 CK2A1 EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, Other; Protein kinase, Ser/Thr (non-receptor) P68400 1457 20p13 human S362-p 449986 ISSVPTPsPLGPLAG molecular association, regulation; enzymatic activity, induced CK2A1(INDUCES); PGK1(INDUCES) 19941816; 30392930; 36646788 5 1 0 -Ssb SSB Transcription initiation complex P32067 20823 2 C2|2 40.95 cM mouse S199-p 2862901 KNEERKQsKVEAKLK molecular association, regulation RNA(INDUCES) 18257391 1 0 0 -PSEN1 PSEN1 Cell surface; EC 3.4.23.-; Membrane protein, integral; Membrane protein, multi-pass; Mitochondrial; Protease P49768 5663 14q24.2 human T74-p 62906104 EEEDEELtLKYGAKH protein conformation 28132667 1 0 0 PS1 pathogenic conformational shift -Rem1 REM1 G protein; G protein, monomeric; G protein, monomeric, RGK O35929 19700 2|2 H1 mouse S262-p 1211201 PSPRRRAsLGQRARR intracellular localization 17605760 1 0 0 -STMN1 STMN1 Cytoskeletal P16949 3925 1p36.11 human S25-p 448555 QAFELILsPRSKESV Stathmin protein stabilization; molecular association, regulation; activity, inhibited; phosphorylation cell cycle regulation; carcinogenesis, inhibited; cell growth, inhibited; apoptosis, induced; cell motility, induced; cell motility, inhibited; signaling pathway regulation; cell growth, induced; cytoskeletal reorganization TUBA1A(DISRUPTS); TUBB(DISRUPTS); TUBA1A(INDUCES); RNF12(DISRUPTS); GRP78(INDUCES) 11015208; 20110360; 23230143; 27130664; 30628717; 30786936; 31546234; 35581193; 7775478; 9271428; 9712920 52 122 91 Stathmin hyperphosphorylation leads to microtubule stability. -Gorasp2 GRASP55 Motility/polarity/chemotaxis; Vesicle Q9R064 113961 3q22 rat T225-p 470123 QMTGTPItPLKDGFT molecular association, regulation cell cycle regulation; cytoskeletal reorganization GRASP55(DISRUPTS) 18385516; 20083603 4 33 6 inhibits Golgi stack formation in interphase cells and enhances Golgi fragmentation in mitotic cells -Mcm3ap GANP ACETYLTRANSFERASE; Acetyltransferase; Karyopherin Q9WUU9 54387 10|10 C1 mouse S502-p 448619 FWHKKKIsPSKKLFP enzymatic activity, induced 11526238 1 4 0 Phosphorylation of this site appears to correlate with higher DNA-primase activity -Cd19 CD19 Cell surface; Membrane protein, integral P25918 12478 7 F3|7 69.01 cM mouse Y493-p 447638 SSLGSQSyEDMRGIL activity, induced; molecular association, regulation cell differentiation, altered PIK3R1(INDUCES) 12387743; 18025150 6 4 15 regulate Akt activation and B-cell differentiation through binding to PI3KR1 -ALK ALK EC 2.7.10.1; KINASE; Kinase, protein; Membrane protein, integral; Oncoprotein; Protein kinase, TK; Protein kinase, tyrosine (receptor) Q9UM73 238 2p23.2-p23.1 human K1610-me 206219700 HYEDTILkSKNSMNQ phosphorylation carcinogenesis, induced; cell growth, induced; signaling pathway regulation 28370702 1 1 0 induces AKT phosphorylation and phosphorylation of itself on other sites, regulates the EML4-ALK pathway -RHO Rhodopsin GPCR, family 1; Membrane protein, integral; Membrane protein, multi-pass; Receptor, GPCR P02699 509933 cow T340-p 448681 ASTTVSKtETSQVAP molecular association, regulation; protein conformation SAG(INDUCES) 15041682 3 2 0 Computational and in vitro data. S343 may be a weaker interaction. -DNMT1 DNMT1 Amino Acid Metabolism - cysteine and methionine; Cell development/differentiation; EC 2.1.1.37; METHYLTRANSFERASE; Methyltransferase; Methyltransferase, DNA; Transcription regulation P26358 1786 19p13.2 human S878-p 27447600 QDYARFEsPPKTQPT BAH protein stabilization; molecular association, regulation; enzymatic activity, induced transcription, induced HDAC1(INDUCES); GATA1(INDUCES); HDAC2(INDUCES); Bcl-11A(INDUCES) DNA(INDUCES) 33227819 1 4 0 -DCK DCK EC 2.7.1.74; Kinase, other; Nucleotide Metabolism - purine; Nucleotide Metabolism - pyrimidine P27707 1633 4q13.3 human S11-p 460585 PPKRSCPsFSASSEG phosphorylation 20544527 4 29 6 regulates phosphorylation of S74 -GJA1 GJA1 Channel, misc.; Membrane protein, integral; Membrane protein, multi-pass; Motility/polarity/chemotaxis P17302 2697 6q22.31 human S325-p 449992 NRMGQAGsTISNSHA Connexin43 protein conformation 23828237 10 14 0 -SIK3 QSK EC 2.7.11.1; KINASE; Kinase, protein; Motility/polarity/chemotaxis; Protein kinase, CAMK; Protein kinase, Ser/Thr (non-receptor) Q9Y2K2 23387 11q23.3 human S551-p 468543 GPLGRRAsDGGANIQ molecular association, regulation transcription, induced 14-3-3 beta(INDUCES) 22588126; 26048985 7 48 120 -AR AR DNA-binding; Nuclear receptor; Transcription factor P10275 367 Xq12 human T851-p 5204777 ACKRKNPtSCSRRFY Hormone_recep activity, induced; protein stabilization; molecular association, regulation; ubiquitination; intracellular localization carcinogenesis, induced; cell growth, induced; transcription, induced Src(INDUCES); RNF6(INDUCES); AR(INDUCES) Other(INDUCES) 22584579; 35163481 2 0 1 induces binding to a "62SLQFLLDT68" co-activator peptide -MAPK14 P38A EC 2.7.11.24; KINASE; Kinase, protein; Protein kinase, CMGC; Protein kinase, Ser/Thr (non-receptor) Q16539 1432 6p21.31 human R70-me 1878212801 IHAKRTYrELRLLKH enzymatic activity, induced cell differentiation, induced; transcription, induced 31243342 1 0 0 MyoD-mediated myogenic differentiation and transcription -Arap3 ARAP3 GAP; GAP, ARF; Motility/polarity/chemotaxis Q8R5G7 106952 18|18 B3 mouse Y1404-p 454958 PVYEEPVyEEVGAFP cell motility, altered; cytoskeletal reorganization 15546919 3 1 3 -TUBA1A TUBA1A Cytoskeletal; Motility/polarity/chemotaxis Q71U36 7846 12q13.12 human K40-ac 460619 DGQMPSDkTIGGGDD Tubulin acetylation; protein stabilization; molecular association, regulation; intracellular localization; phosphorylation cell cycle regulation; carcinogenesis, induced; cell motility, induced; transcription, induced; cell motility, inhibited; signaling pathway regulation; cell adhesion, inhibited; DNA repair, induced; autophagy, induced; cell growth, induced; cell differentiation, induced; cell motility, altered; apoptosis, inhibited; cytoskeletal reorganization KIF5B(INDUCES); NFAT1(DISRUPTS); LRRK2(DISRUPTS) 12024216; 12606581; 17084703; 19185337; 19896110; 20308065; 20484055; 20978170; 21278340; 22193721; 22658602; 23580651; 24275654; 26382850; 26763233; 26870991; 27311481; 27311773; 27430620; 27454931; 27721410; 27836544; 28394342; 31919191; 32514048; 32788234; 32846968; 32885602; 32908309; 34503512; 35504282; 35884497 71 7 11 staining for trimethylation of H3K9 increased early in infection; acetylation of tubulin enables microtubules from this center to rotate the nucleus to maximizing virus replication; TMIGD1/moesin pathway may regulate tubulin acetylation, affecting cytoskeletal organization and cell motility; Runx2 silencing is accompanied by reduced microtubule stability -PPP1R3C PPP1R3C Motility/polarity/chemotaxis; Protein phosphatase, regulatory subunit Q9UQK1 5507 10q23.32 human S33-p 6423500 MRLCLAHsPPVKSFL protein degradation; ubiquitination; enzymatic activity, inhibited 19171932 1 7 1 -Pak1 PAK1 EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, STE; Protein kinase, Ser/Thr (non-receptor) P35465 29431 1q32 rat T84-p 450680 LPSDFEHtIHVGFDA PBD enzymatic activity, inhibited 14707132 1 0 0 prevents activation by Cdc42 -Oprk1 KOR-1 GPCR, family 1; Membrane protein, integral; Membrane protein, multi-pass; Receptor, GPCR P33534 18387 1 A1|1 1.89 cM mouse S356-p 52467200 KMRMERQsTNRVRNT receptor internalization, induced; intracellular localization 26635353; 28893975 2 1 0 -FLOT1 FLOT1 Adaptor/scaffold O75955 10211 6p21.33 human Y56-p 35494100 NVKSEKVyTRHGVPI Band_7 molecular association, regulation SDHB(INDUCES) 24983503 1 0 0 decreased ROS productioned compared to Y56F and Y149F mutants -VIM Vimentin Cytoskeletal; Motility/polarity/chemotaxis P08670 7431 10p13 human S8-p 471087 MSTRSVSsSSYRRMF Filament_head cell motility, altered 19291697 3 3 1 -Ulk1 ULK1 Autophagy; EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, Other; Protein kinase, Ser/Thr (non-receptor) O70405 22241 5|5 F mouse S224-p 10428802 GKAPFQAsSPQDLRL Pkinase cell cycle regulation; autophagy, induced; cell growth, induced 32516310 1 1 0 -MDM2 MDM2 EC 6.3.2.-; EC 6.3.2.19; Inhibitor; Ligase; NEDDYLATION LIGASE; Neddylation Ligase; Nucleolus; Oncoprotein; UBIQUITIN LIGASE; Ubiquitin conjugating system; Ubiquitin ligase Q00987 4193 12q15 human Y281-p 4251185 EVYQVTVyQAGESDT protein stabilization transcription, inhibited UBE2M(INDUCES) 25624478 2 1 0 stabilization of p53 levels, neddylated-P53, represses p53-mediated maspin gene expression -Unc5c UNC5C Membrane protein, integral; Receptor, misc. O08747 22253 3 H1|3 65.57 cM mouse Y568-p 12563302 QGRVYEMyVTVHRKE ZU5 molecular association, regulation PLCG1(INDUCES); SHP-2(INDUCES) 11533026 1 1 0 SHP-2 and UNC5C bind in vitro and in vivo -Cebpb C/EBP-beta DNA-binding; Motility/polarity/chemotaxis; Transcription factor P21272 24253 3q42 rat K134-sm 6140810 PPPPAALkAEPGFEP protein degradation 35002525 3 2 0 C/EBP-beta PARylation inhibits its SUMOylation at K174 -RHOT1 RHOT1 EC 3.6.5.-; G protein; G protein, monomeric; G protein, monomeric, Rho; Hydrolase; Membrane protein, integral; Mitochondrial Q8IXI2 55288 17q11.2 human K153-ub 22250894 ECSAKNLkNISELFY Ras protein degradation; intracellular localization autophagy, induced 34152608 2 2 0 induces mitophagy by recruiting Parkin to mitochondria -PDE4D PDE4D iso2 EC 3.1.4.53; Nucleotide Metabolism - purine; Phosphodiesterase Q08499-2 5144 5q11.2-q12.1 human S579-p 451090 YQSTIPQsPSPAPDD enzymatic activity, inhibited 10022832; 10828059; 16973330 7 3 0 -CTDP1 CTDP1 EC 3.1.3.16; Motility/polarity/chemotaxis; PHOSPHATASE; Protein phosphatase, Ser/Thr (non-receptor); Transcription initiation complex Q9Y5B0 9150 18q23 human T584-p 455468 EEEEEEDtDEDDHLI molecular association, regulation; enzymatic activity, induced transcription, altered GTF2F1(INDUCES) 15723518; 19215094 2 0 0 -EIF6 EIF6 Nucleolus; Translation; Translation initiation P56537 3692 20q11.22 human S175-p 17535703 EDQDELSsLLQVPLV eIF-6 intracellular localization 21084295 1 2 0 required for the nuclear export of eIF6 -MYB Myb DNA-binding; Oncoprotein; Transcription factor P10242 4602 6q23.3 human S11-p 448186 RPRHSIYsSDEDDED molecular association, regulation transcription, altered DNA(DISRUPTS) 7735324 5 1 1 -BUB3 BUB3 Cell cycle regulation O43684 9184 10q26.13 human Y207-p 463080 EGRVAVEyLDPSPEV molecular association, regulation; intracellular localization cell cycle regulation; carcinogenesis, induced; cell growth, induced; apoptosis, inhibited; cytoskeletal reorganization CASC5(INDUCES) 24316223 1 3 2 -DRD2 DRD2 GPCR, family 1; Membrane protein, integral; Membrane protein, multi-pass; Receptor, GPCR P14416 1813 11q23.2 human S354-p 467255 PNGKTRTsLKTMSRR 7tm_1 molecular association, regulation; intracellular localization; activity, inhibited FLNA(DISRUPTS) 10692483 2 0 0 inhibits D2 receptor clustering on the cell surface -CIITA CIITA DNA-binding; EC 2.7.11.1; KINASE; Protein kinase, Ser/Thr (non-receptor); Transcription, coactivator/corepressor P33076 4261 16p13.13 human K141-ac 458928 MPAEVGQkSQKRPFP intracellular localization transcription, induced 11046145 1 0 0 nuclear localization -AKT1 Akt1 EC 2.7.11.1; KINASE; Kinase, protein; Oncoprotein; Protein kinase, AGC; Protein kinase, Ser/Thr (non-receptor) P31749 207 14q32.33 human K64-ub 1872904200 VAQCQLMkTERPRPN PH phosphorylation apoptosis, inhibited 28412322 1 0 0 enhaces Akt phosphorylation -MARCKS MARCKS Actin-binding; Motility/polarity/chemotaxis P16527 396473 chicken S26-p 455959 PGEAVAAsPSKANGQ MARCKS molecular association, regulation; intracellular localization cell cycle regulation; cell motility, induced; cell differentiation, induced ACTA1(INDUCES) 19366616; 23470634; 23634231 5 50 8 -Gja4 GJA4 Cell adhesion; Membrane protein, integral; Membrane protein, multi-pass P28235 14612 4 D2.2|4 61.47 cM mouse S321-p 1867850301 QGGRKSPsRPNSSAS protein conformation cell cycle regulation; apoptosis, induced 30736283 1 0 0 -THBS1 THBS1 Inhibitor; Motility/polarity/chemotaxis P07996 7057 15q14 human K472-ub 52490405 PSPQMNGkPCEGEAR TSP_1 protein degradation 26676607 0 1 0 -Sik2 QIK EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, CAMK; Protein kinase, Ser/Thr (non-receptor) Q8CFH6 235344 9|9 A5.3 mouse S343-p 2150903 RLKSHRSsFPVEQRL enzymatic activity, inhibited transcription, induced 23241891 3 6 4 -ELK1 ELK1 DNA-binding; Transcription factor P19419 2002 Xp11.23 human T417-p 452139 ISVDGLStPVVLSPG apoptosis, induced 34572320 8 0 1 -MRE11 MRE11A Cell cycle regulation; DNA repair, damage; DNA-binding; Deoxyribonuclease P49959 4361 11q21 human R580-m2 62978406 GRGRRGGrGQNSASR DNA repair, altered 15741314 0 1 0 -CDCA5 CDCA5 Cell cycle regulation Q96FF9 113130 11q13.1 human S181-p 20727382 AEDLSGVsPVVCSKL Sororin molecular association, regulation; activity, inhibited cell cycle regulation SCC-112(DISRUPTS); H2A.1(DISRUPTS); SMC3(DISRUPTS) 21878504; 23901111 2 7 0 -ADD1 ADD1 Cytoskeletal; Motility/polarity/chemotaxis P35611 118 4p16.3 human T724-p 5246050 KKKKKFRtPSFLKKS activity, induced; molecular association, regulation carcinogenesis, induced; cell motility, induced; transcription, induced; cytoskeletal reorganization ACTN1(DISRUPTS) 31548578 1 15 15 Increase lamellapodia formation and cell invasion -Stxbp1 STXBP1 Vesicle P61765 25558 3p11 rat S306-p 448743 VSQEVTRsLKDFSSS Sec1 exocytosis, altered 16997485 3 0 0 regulates protein secretion by increasing vesicle pools replenishment after stimulation -SLK SLK EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, STE; Protein kinase, Ser/Thr (non-receptor) Q9H2G2 9748 10q24.33-q25.1 human S347-p 466943 SSDLSIAsSEEDKLS enzymatic activity, inhibited 16837460 1 34 2 site is critical for v-src dependent modulation of SLK kinase activity -CDCA7 CDCA7 Cell cycle regulation Q9BWT1 83879 2q31.1 human T163-p 4774845 SRRPRRRtFPGVASR molecular association, regulation; intracellular localization 14-3-3 beta(INDUCES); Myc(DISRUPTS) 23166294 1 5 8 14-3-3 competes with MYC for binding to CDCA7 ; localization to cytoplasm after binding of 14-3-3 -MAF MAF Cell development/differentiation; DNA-binding; Oncoprotein; Transcription factor; Tumor suppressor O75444 4094 16q23.2 human Y131-p 25673103 LQGGFDGyARGAQQL activity, induced; molecular association, regulation transcription, induced DNA(INDUCES) 22798672 2 0 0 Interacts with IL-4 promoter and transactivates IL-4 -Ctnna1 CTNNA1 Actin-binding; Motility/polarity/chemotaxis P26231 12385 18 B1|18 18.89 cM mouse T654-p 467709 DFDVRSRtSVQTEDD Vinculin intracellular localization CDH1(DISRUPTS) 25970250 1 27 8 -MPIG6B G6B Immunoglobulin superfamily; Membrane protein, integral; Receptor, misc. O95866 80739 6p21.33 human S226-p 1983255 LSRPRRLsTADPADA G6B molecular association, regulation SH2D1B(NOT_REPORTED); Arg(NOT_REPORTED) 23322602 0 2 0 -HMGA2 HMGA2 DNA-binding; Oncoprotein P52926 8091 12q14.3 human K26-ac 474713 PAAPAPQkRGRGRPR AT_hook protein stabilization; molecular association, regulation DNA(INDUCES) 32313942 1 0 27 -TRPM4 TRPM4 Membrane protein, integral; Membrane protein, multi-pass Q8TD43 54795 19q13.33 human S1152-p 12559512 SERLKRTsQKVDLAL activity, induced 15590641 1 0 0 -TERF1 TRF1 DNA-binding P54274 7013 8q21.11 human T358-p 12115364 KKESRRAtESRIPVS protein stabilization; molecular association, regulation; phosphorylation carcinogenesis, induced; chromatin organization, altered; cell growth, induced; transcription, inhibited DNA(INDUCES) 33690611 1 0 1 binds telomeric DNA, inhibits CHK phosphorylation -CCR7 CCR7 GPCR, family 1; Membrane protein, integral; Membrane protein, multi-pass; Motility/polarity/chemotaxis; Receptor, GPCR P32248 1236 17q21.2 human S377-p 455292 AETTTTFsP______ phosphorylation 15054093 1 0 0 ERK1/2 phosphorylation -NABP2 OBFC2B Cell cycle regulation; DNA repair, damage Q9BQ15 79035 12q13.3 human S134-p 25302960 NDSNPSAsQPTTGPS DNA repair, induced 28448822 1 1 1 -TTK TTK Cancer Testis Antigen (CTA); EC 2.7.12.1; KINASE; Kinase, protein; Protein kinase, Other; Protein kinase, dual-specificity (non-receptor) P33981 7272 6q14.1 human K86-ub 12109968 LSDALLNkLIGRYSQ protein degradation cell cycle regulation 34586601 1 5 2 -Amot AMOT Q8VHG2 27494 X|X F2 mouse S176-p 28699604 QGHVRSLsERLMQMS protein stabilization; molecular association, regulation; intracellular localization signaling pathway regulation ACTB(DISRUPTS); LATS2(INDUCES) 23791731; 28947533 8 0 0 diffused cytoplasmic distribution of Amot vs colocalization of Amot and F-actin; Hippo pathway activation -Neurog1 neurogenin 1 Cell development/differentiation; DNA-binding; Transcription factor P70595 29410 17p14 rat S208-p 7590802 SPLSDPSsPSASEDF transcription, induced; cell growth, altered 19365559 1 0 0 -MDM2 MDM2 EC 6.3.2.-; EC 6.3.2.19; Inhibitor; Ligase; NEDDYLATION LIGASE; Neddylation Ligase; Nucleolus; Oncoprotein; UBIQUITIN LIGASE; Ubiquitin conjugating system; Ubiquitin ligase Q00987 4193 12q15 human T218-p 450150 SSSESTGtPSNPDLD molecular association, regulation; intracellular localization ARF1(INDUCES) 25915850 4 0 0 Arf-dependent nucleolus localization -MAP3K15 MAP3K15 EC 2.7.11.25; KINASE; Kinase, protein; Protein kinase, STE; Protein kinase, Ser/Thr (non-receptor) Q6ZN16 389840 Xp22.12 human T808-p 904653402 GVNPCTEtFTGTLQY Pkinase molecular association, regulation PPP6C(INDUCES) 29539411 1 0 0 required for interaction -AFDN Afadin iso3 Cell adhesion; Motility/polarity/chemotaxis; Oncoprotein P55196-3 4301 6q27 human S1718-p 481813 KERQRLFsQGQDVSN signaling pathway regulation 30670780 2 47 300 PI3K/Akt signaling -DHPS DHPS Cell cycle regulation; EC 2.5.1.46; Transferase P49366 1725 19p13.13 human S233-p 1870426002 KNHIPVFsPALTDGS DS enzymatic activity, induced cell growth, induced 32989218 1 0 0 -USF1 USF1 DNA-binding; Transcription factor P22415 7391 1q23.3 human T153-p 463815 EALLGQAtPPGTGQF activity, induced; acetylation transcription, induced; transcription, inhibited 11532965; 16622840; 19389701; 21873430 4 1 0 -FOXA1 FOXA1 DNA-binding; Transcription factor P55317 3169 14q21.1 human Y429-p 60189900 QALQYSPyGSTLPAS HNF_C transcription, induced 27883218 1 0 0 -Xbp1 XBP1 DNA-binding; Transcription factor O35426 22433 11 A1|11 3.61 cM mouse S61-p 21688102 RQRLTHLsPEEKALR bZIP_1 intracellular localization apoptosis, induced; transcription, induced 21892182; 28717189; 34030589 4 7 0 -KAT2B PCAF ACETYLTRANSFERASE; Acetyltransferase; EC 2.3.1.48; Nuclear receptor co-regulator Q92831 8850 3p24.3 human K442-ac 458988 HVLEEAKkPRVMGDI enzymatic activity, induced 12888487 1 0 0 in vitro -Synj1 SYNJ1 Carbohydrate Metabolism - inositol phosphate; EC 3.1.3.36; Motility/polarity/chemotaxis; Phosphatase, lipid; Vesicle Q62910 85238 11q11 rat S1160-p 450679 REMEAPKsPGTARKD molecular association, regulation endophilin A1(DISRUPTS) 14704270 1 2 2 -RORA RORA DNA-binding; Nuclear receptor P35398 6095 15q22.2 human K441-ub 1883509401 SWLQEKVkIEKLQQK Hormone_recep protein degradation 36114756 1 0 0 PRMT5 is involved in RORa degradation by regulating ITCH binding R37A (mutant) -MIF MIF Amino Acid Metabolism - phenylalanine; Amino Acid Metabolism - tyrosine; Apoptosis; Cell development/differentiation; Cytokine; EC 5.3.2.1; EC 5.3.3.12; Isomerase P14174 4282 22q11.23 human S112-gl 48990005 ANVGWNNsTFA____ MIF molecular association, regulation carcinogenesis, inhibited; cell growth, inhibited; cell motility, inhibited EGFR(INDUCES) 26280537 1 1 0 binds to EGFR and blocks EGF binding to EGFR -MSH6 MSH6 DNA-binding P52701 2956 2p16.3 human K1126-m1 58123204 EEEQENGkAYCVLVT molecular association, regulation L3MBTL iso4(INDUCES) 23583077 0 1 0 -CREM CREM DNA-binding; Transcription factor Q03060 1390 10p11.21 human S271-p 450065 QGVVMAAsPGSLHSP ubiquitination; intracellular localization transcription, induced 21767532 3 14 2 -MAP2K6 MKK6 iso2 EC 2.7.12.2; KINASE; Kinase, protein; Protein kinase, STE; Protein kinase, dual-specificity (non-receptor) P52564-2 5608 17q24.3 human S151-p 448194 ISGYLVDsVAKTIDA Pkinase enzymatic activity, induced 8621675 13 20 65 -PSEN1 PSEN1 Cell surface; EC 3.4.23.-; Membrane protein, integral; Membrane protein, multi-pass; Mitochondrial; Protease P49768 5663 14q24.2 human S319-p 3397301 NSKYNAEsTERESQD Presenilin protein stabilization; enzymatic activity, induced 18667537 1 0 0 -TP53 p53 Activator; DNA-binding; Motility/polarity/chemotaxis; Nuclear receptor co-regulator; Transcription factor; Tumor suppressor P04637 7157 17p13.1 human S106-p 27300200 SQKTYQGsYGFRLGF P53 protein stabilization MDM2(DISRUPTS) 23201157 1 1 0 -H2BC3 H2B DNA-binding P33778 3018 6p22.2 human K24-ac 482539 AITKAQKkDGKKRKR Histone molecular association, regulation polybromo 1(INDUCES) 20368734 1 1 7 varying site specificity binding for each bromodomain 1-6 -CARM1 CARM1 EC 2.1.1.125; METHYLTRANSFERASE; Methyltransferase; Methyltransferase, protein arginine; Nuclear receptor co-regulator Q86X55 10498 19p13.2 human S447-p 25268707 LIANKRQsYDISIVA molecular association, regulation transcription, induced; signaling pathway regulation ER-alpha(INDUCES) 20360387 1 0 0 -UIMC1 RAP80 Nuclear receptor co-regulator; Transcription, coactivator/corepressor Q96RL1 51720 5q35.2 human S46-p 470701 AFIVISDsDGEEPKE molecular association, regulation SUMO2(INDUCES) 26719330 1 28 3 -TSC2 TSC2 Cell cycle regulation; GAP; GAP, misc.; Nuclear receptor co-regulator; Tumor suppressor P49815 7249 16p13.3 human S981-p 454014 AFRCRSIsVSEHVVR molecular association, regulation; intracellular localization; activity, inhibited carcinogenesis, inhibited; cell growth, inhibited; autophagy, inhibited; signaling pathway regulation 14-3-3 zeta(INDUCES); 14-3-3 epsilon(INDUCES) 16636147; 27451907; 32308763 7 30 14 cell survival induced; TSC2/RHEB/mTOR signaling pathway -POU6F1 POU6F1 DNA-binding; Transcription factor Q14863 5463 12q13.13 human S197-p 1869383200 KLDITPKsAQKLKPV Pou molecular association, regulation cell differentiation, induced; cytoskeletal reorganization DNA(DISRUPTS) 31665313 1 1 0 role in skeletal muscle differentiation and skeletal myogenesis -PHLPP1 PHLPP EC 3.1.3.16; PHOSPHATASE; Protein phosphatase, Ser/Thr (non-receptor); Tumor suppressor O60346 23239 18q21.33 human S412-p 30988996 PLPQTASsPQPQQKA cell cycle regulation 33397691 1 2 0 -TCF3 E2A iso2 Cell development/differentiation; DNA-binding; Oncoprotein; Transcription factor P15923-2 6929 19p13.3 human S359-p 465682 SPSTPVGsPQGLAGT molecular association, regulation transcription, induced NEUROD1(INDUCES) 12810726 2 7 31 -AGTR1 AT1 GPCR, family 1; Membrane protein, integral; Membrane protein, multi-pass; Receptor, GPCR P30556 185 3q24 human S338-p 452092 STKMSTLsYRPSDNV activity, induced; molecular association, regulation; intracellular localization; receptor internalization, altered ARRB1(INDUCES); ARRB2(INDUCES) 11579203; 15177932 5 0 0 -LZTS2 LZTS2 Nuclear export Q9BRK4 84445 10q24.31 human S220-p 1871717501 PSGTLSDsGRNSLSS protein degradation; molecular association, regulation; ubiquitination; phosphorylation carcinogenesis, induced; cell motility, induced; cell growth, induced; signaling pathway regulation BTRC(INDUCES) 33420362 1 0 0 induces phosphorylation of downstream targets thus inducing the PI3K/AKT signaling pathway -MAML1 MAML1 Transcription, coactivator/corepressor Q92585 9794 5q35.3 human K188-ac 11319879 LGLDSLNkKRLADSS molecular association, regulation Notch 1(INDUCES) 28625977 1 2 0 -PHB2 BAP37 Mitochondrial; Nuclear receptor co-regulator; Transcription, coactivator/corepressor Q99623 11331 12p13.31 human S39-p 1868188300 VAYGVREsVFTVEGG molecular association, regulation autophagy, induced LC3A(INDUCES) 33820826 2 0 0 induces mitophagy -CTNNB1 CTNNB1 Actin-binding; Cell adhesion; Motility/polarity/chemotaxis; Nuclear receptor co-regulator; Oncoprotein; Transcription factor P35222 1499 3p22.1 human T393-p 449562 RNLSDAAtKQEGMEG activity, induced; molecular association, regulation; protein stabilization; phosphorylation transcription, induced; transcription, altered axin 1(DISRUPTS) 12700239; 19565571 2 0 0 -NFATC3 NFAT4 DNA-binding; Transcription factor Q12968 4775 16q22.1 human S163-p 448857 SYRESSLsPSPASSI intracellular localization transcription, inhibited 9374467 1 3 0 -Rarg RARG iso2 DNA-binding; Nuclear receptor P18911-2 19411 15 F3|15 57.4 cM mouse S68-p 455544 EMVPSSPsPPPPPRV activity, induced; protein degradation transcription, altered 12032135 3 0 0 -SPEN SHARP Nuclear receptor co-regulator; RNA-binding; Spliceosome; Transcription factor Q96T58 23013 1p36.21-p36.13 human T3568-p 455622 EGVARRMtVETDYCL SPOC transcription, altered 15824732 1 0 0 -NCOA3 SRC-3 ACETYLTRANSFERASE; Acetyltransferase; EC 2.3.1.48; Motility/polarity/chemotaxis; Nuclear receptor co-regulator; Transcription, coactivator/corepressor Q9Y6Q9 8202 20q13.12 human S543-p 454108 SLLSTLSsPGPKLDN NCOA_u2 molecular association, regulation carcinogenesis, induced; cell growth, induced; transcription, induced ER-alpha(DISRUPTS) 15383283; 16760465; 23850489; 33542078 7 0 0 -Atg13 ATG13 Autophagy; Vesicle Q91YI1 51897 2|2 E1 mouse S224-p 53377101 DRPYPSSsPMHPCNY autophagy, inhibited 26801615 2 2 0 -CORO7 coronin 7 Vesicle P57737 79585 16p13.3 human Y758-p 2853108 GDTRVFLyELLPESP phosphorylation signaling pathway regulation 33162394 2 0 0 inhibits phosphorylation of YAP7 and hence the Hippo signaling pathway -Pak1 PAK1 EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, STE; Protein kinase, Ser/Thr (non-receptor) P35465 29431 1q32 rat S149-p 448171 YMSFTDKsAEDYNSS enzymatic activity, induced 11278486 1 2 31 -YAP1 YAP1 Oncoprotein; Transcription, coactivator/corepressor P46937 10413 11q22.1 human S403-p 3190675 ESTDSGLsMSSYSVP protein degradation; ubiquitination carcinogenesis, inhibited; cell motility, inhibited 36828627 2 3 0 -RBM17 RBM17 RNA splicing; RNA-binding; Spliceosome Q96I25 84991 10p15.1 human S62-p 27936100 IDLKRGGsSDDRQIV molecular association, regulation; phosphorylation cell motility, induced RNA(DISRUPTS) 23519612 1 2 0 induced cell invasion, enhanced Cortactin phosphorylation at ERK-dependent sites -Cry1 CRY1 DNA-binding; Lyase; Transcription, coactivator/corepressor P97784 12952 10 C1|10 41.63 cM mouse K107-ub 27766300 YDSEPFGkERDAAIK DNA_photolyase protein stabilization; molecular association, regulation 23452856 1 2 0 -CREBBP CBP ACETYLTRANSFERASE; Acetyltransferase; DNA-binding; EC 2.3.1.48; Motility/polarity/chemotaxis; Nuclear receptor co-regulator; Transcription, coactivator/corepressor Q92793 1387 16p13.3 human R768-me 475952 GMAISPSrMPQPPNM molecular association, regulation; acetylation; enzymatic activity, induced transcription, induced; signaling pathway regulation RAC3(INDUCES); ER-alpha(INDUCES) DNA(INDUCES) 12374746; 21632823 2 0 0 steroid hormone signaling, GRIP1 and steroid hormone-induced transcription; induces CBP autoacetylation -Lck Lck EC 2.7.10.2; KINASE; Kinase, protein; Oncoprotein; Protein kinase, TK; Protein kinase, tyrosine (non-receptor) P06240 16818 4 D2.2|4 63.26 cM mouse S59-p 447820 EGSLPPAsPLQDNLV enzymatic activity, inhibited cell growth, inhibited 25535246; 8077654 10 2 7 -KAT5 Tip60 ACETYLTRANSFERASE; Acetyltransferase; EC 2.3.1.48; Nuclear receptor co-regulator; Nucleolus Q92993 10524 11q13.1 human K282-ac 1872267901 CLQRHLTkCDLRHPP zf-MYST protein degradation apoptosis, inhibited 16001085 1 0 0 Tip60 targeting by HIV Tat -MITF MITF DNA-binding; Oncoprotein; Transcription factor O75030 4286 3p13 human K372-ub 964527258 QREQQRAkELENRQK protein degradation; molecular association, regulation autophagy, induced SQSTM1(INDUCES) 35092699 1 1 0 -AFG3L2 AFG3L2 Cell development/differentiation; Chaperone; EC 3.4.24.-; Membrane protein, integral; Membrane protein, multi-pass; Mitochondrial; Protease Q9Y4W6 10939 18p11.21 human Y179-p 462232 WKDFVNNyLSKGVVD FtsH_ext protein processing 24767997 1 0 18 prevents SPG7 processing, regulates mitochondrial bioenergetics and mROS production -STMN1 STMN1 Cytoskeletal P16949 3925 1p36.11 human S38-p 448556 SVPEFPLsPPKKKDL Stathmin protein degradation; protein stabilization; molecular association, regulation; activity, inhibited; phosphorylation cell cycle regulation; carcinogenesis, inhibited; cell growth, inhibited; apoptosis, induced; cell motility, induced; cell motility, inhibited; signaling pathway regulation; cytoskeletal reorganization; cell growth, altered TUBA1A(DISRUPTS); TUBB(DISRUPTS); GRP78(INDUCES) 11015208; 19033656; 19162178; 20110360; 23230143; 27130664; 31546234; 7775478; 8144611; 9271428; 9712920 49 114 166 Stathmin hyperphosphorylation leads to microtubule stability. -CTLA4 CTLA-4 Immunoglobulin superfamily; Membrane protein, integral P16410 1493 2q33.2 human Y218-p 450898 CEKQFQPyFIPIN__ molecular association, regulation; intracellular localization SHP-1(INDUCES) 10604992; 11970985 3 0 0 -PRKRA PACT Activator; RNA processing; RNA-binding O75569 8575 2q31.2 human S246-p 470037 TDYIQLLsEIAKEQG molecular association, regulation; enzymatic activity, induced apoptosis, altered; apoptosis, induced PACT(INDUCES) 16982605; 21526770; 22473766 4 0 1 PKR enzymatic activity induced; activates PKR -MAP3K5 ASK1 EC 2.7.11.25; KINASE; Kinase, protein; Protein kinase, STE; Protein kinase, Ser/Thr (non-receptor) Q99683 4217 6q23.3 human S1033-p 451423 EDHSAPPsPEEKDSG enzymatic activity, inhibited; phosphorylation apoptosis, altered 15094778; 35438255 2 32 0 -CSF2RB CSF2RB Membrane protein, integral; Receptor, cytokine P32927 1439 22q12.3 human Y593-p 450103 SFDFNGPyLGPPHSR activity, induced; molecular association, regulation; receptor internalization, altered; phosphorylation apoptosis, altered; cell motility, altered; transcription, altered; cell growth, altered GRB2(INDUCES); Fos(NOT_REPORTED); SHC1(INDUCES); SHP-2(INDUCES) 10329850; 10672044; 10704825; 10760518; 17638849; 8631792; 8752899; 9209304; 9257712 12 0 0 Y593 may be required for phosphorylation of Shc.; Y593 phosphorylation is essential for Shc phosphorylation and activation of Shc and the c-fos promoter. ; Y593-p is important for activation of the Fos promoter. ; Phosphorylation of Y628, Y711, or Y766 is necessary and sufficient for STAT activation by IL-5. -GBF1 GBF1 GEF; GEF, ARF Q92538 8729 10q24.32 human Y877-p 1875829500 QDILEDMyHAIKNEE Sec7 molecular association, regulation; intracellular localization; protein conformation ARF1(INDUCES) 34870592 1 1 0 induces GALNT relocation -Gsk3b GSK3B EC 2.7.11.1; EC 2.7.11.26; KINASE; Kinase, protein; Protein kinase, CMGC; Protein kinase, Ser/Thr (non-receptor) Q9WV60 56637 16|16 B3 mouse S9-p 449111 SGRPRTTsFAESCKP activity, induced; molecular association, regulation; protein stabilization; intracellular localization; enzymatic activity, inhibited; activity, inhibited; phosphorylation cell cycle regulation; carcinogenesis, induced; cell motility, induced; cell adhesion, induced; signaling pathway regulation; cell growth, induced; transcription, inhibited; cell growth, altered; cell differentiation, inhibited; cell growth, inhibited; transcription, induced; transcription, altered; neural plasticity; cell differentiation, induced; apoptosis, inhibited; cytoskeletal reorganization; autophagy, inhibited 14-3-3 zeta(INDUCES) 11035810; 12095987; 14522959; 15791206; 15845746; 16055726; 17178402; 18851840; 19106302; 20111716; 20332342; 20592205; 20724593; 21821713; 21998135; 22172670; 24614172; 28562582; 31672472; 32209671; 33804171; 33829789; 33863923; 34140410; 34203583; 34453977; 34638997; 34642308; 34710087; 34778891; 34794022; 34930892; 34949833; 35145222; 35358489; 35950912; 36027949; 36065437; 36090685; 36103829; 36209826; 36293516; 37033243; 37370133; 37392853 570 46 227 regulatws the NFAT signaling pathway; inhibits HIF1A degradation -HVCN1 HVCN1 iso4 Channel, cation; Membrane protein, integral; Membrane protein, multi-pass Q96D96-4 84329 12q24.11 human T9-p 472529 SKFLRHFtVVGDDYH activity, induced; receptor internalization, induced carcinogenesis, induced 25425665 2 0 3 HVCN1s channel currents turn on more rapidly and current amplitude is increased than HVCN1-L channels Receptor-internalization more in HVCN1-L than HVCN1s -Ncor1 N-CoR1 Nuclear receptor co-regulator; Transcription, coactivator/corepressor Q60974 20185 11|11 B2 mouse S2348-p 2888301 NKSNSRKsKSPIPGQ molecular association, regulation 14-3-3 beta(INDUCES) 17630505 1 5 1 -KDM1A LSD1 DEMETHYLASE; Demethylase; EC 1.-.-.-; Nuclear receptor co-regulator; Oxidoreductase; Transcription factor O60341 23028 1p36.12 human S126-p 3175618 EYREMDEsLANLSED cell cycle regulation 28344766 1 12 0 S126 phosphorylation promotes LSD1 release from chromatin during mitosis -ECHS1 ECHS1 Amino Acid Metabolism - lysine degradation; Amino Acid Metabolism - tryptophan; Amino Acid Metabolism - valine, leucine and isoleucine degradation; Carbohydrate Metabolism - butanoate; Carbohydrate Metabolism - propanoate; EC 4.2.1.17; Lipid Metabolism - fatty acid; Lipid Metabolism - fatty acid elongation in mitochondria; Lyase; Mitochondrial; Other Amino Acids Metabolism - beta-alanine; Secondary Metabolites Metabolism - limonene and pinene degradation P30084 1892 10q26.3 human K101-ac 467120 FAAGADIkEMQNLSF ECH_1 protein degradation; ubiquitination; intracellular localization; enzymatic activity, inhibited carcinogenesis, induced; signaling pathway regulation 28878358 1 7 16 activates mTOR signaling -TYK2 Tyk2 EC 2.7.10.2; KINASE; Kinase, protein; Protein kinase, TK; Protein kinase, tyrosine (non-receptor) P29597 7297 19p13.2 human Y1055-p 447503 VPEGHEYyRVREDGD PK_Tyr_Ser-Thr enzymatic activity, induced signaling pathway regulation 31341059; 8702790 8 2 5 -BUB3 BUB3 Cell cycle regulation O43684 9184 10q26.13 human S211-p 452546 AVEYLDPsPEVQKKK molecular association, regulation carcinogenesis, inhibited; apoptosis, induced; transcription, inhibited DMAP1(INDUCES) DNA(INDUCES) 30553276 1 14 0 Blocks mitotic arrest -NPM/ALK NPM-ALK KINASE; Kinase, protein; Protein kinase, TK; Protein kinase, tyrosine (receptor) AAA58698 human Y342-p 27275106 RDIYRASyYRKGGCA PK_Tyr_Ser-Thr enzymatic activity, induced 19887368 3 2 3 -Myb Myb DNA-binding; Oncoprotein; Transcription factor P06876 17863 10 A3|10 9.75 cM mouse K523-sm 486352 PPLLKKIkQEVESPT Cmyb_C sumoylation; protein stabilization; intracellular localization; protein conformation transcription, inhibited 11779867; 16162816; 17077080 4 1 0 slight increase in conjugation of two and three molecules of SUMO-2 with S528A phospho-mutant under stress -TFAM TFAM DNA-binding; Transcription regulation Q00059 7019 10q21.1 human K154-ac 1876567506 KELTLLGkPKRPRSA HMG_box_2 transcription, induced 35278431 0 1 0 -DDX21 DDX21 EC 3.6.4.13; Helicase; Nucleolus; RNA processing; RNA-binding Q9NR30 9188 10q22.1 human K18-ac 461852 LESDTAMkKGETLRK enzymatic activity, inhibited transcription, inhibited 28790157 1 0 28 Inhibits DDX21 helicase activity, impairs genomic stability, R-loop mediated stalling of RNA polymerase -ADRB2 ADRB2 GPCR, family 1; Membrane protein, integral; Membrane protein, multi-pass; Receptor, GPCR P07550 154 5q32 human T68-p 4047201 FERLQTVtNYFITSL 7tm_1 activity, induced 17925438 1 0 0 G-protein activation -Lat LAT Adaptor/scaffold; Membrane protein, integral O54957 16797 7|7 F3 mouse Y175-p 448004 SVESCEDyVNVPESE LAT intracellular localization; phosphorylation cell adhesion, altered Fyn(INDUCES) 15470052; 17579183 24 1 17 Localization of recruited PLCG2 to the membrane/cytoskeleton; Fyn may be involved in LAT phosphorylation.; regulates exocytosis and cytokine secretion -GIT1 GIT1 GAP; GAP, ARF; Motility/polarity/chemotaxis Q9Y2X7 28964 17q11.2 human S700-p 465672 PALEPVRsSLRLLNA GIT1_C molecular association, regulation cytoskeletal reorganization PXN iso2(INDUCES) 16797488 1 2 0 -RPAP3 RPAP3 Unknown function Q9H6T3 79657 12q13.11 human S116-p 472436 DSTHESLsQESESEE molecular association, regulation 35129352 1 14 8 inhibits binding to ribosomal proteins and biogenesis factors associated with small (40S) and large (60S) subunits of the ribosome -Dlg2 PSD-93 Adaptor/scaffold Q91XM9 23859 7 E1|7 51.07 cM mouse Y348-p 450885 TRPPEPVySTVNKLC molecular association, regulation CSK(INDUCES) 13129934 1 3 147 -ADARB1 RED1 EC 3.5.4.37; Hydrolase; Nucleolus; RNA-binding P78563 104 21q22.3 human T553-p 31884906 LQGERLLtMSCSDKI A_deamin enzymatic activity, inhibited 31095429 1 1 0 -GHR GH receptor Membrane protein, integral; Receptor, cytokine P10912 2690 5p13.1-p12 human Y595-p 450480 SEMPVPDyTSIHIVQ GHBP molecular association, regulation SOCS2(INDUCES) 25505247 3 1 0 The following proteins have been pulled-down by GHR_Y595 beads: CRL5-SOCS2 E3 ligase complex (SOCS2, EloB, EloC, Cul5, Rbx2) , and Cul1, FBXO31, Rbx1, Skp1, CISH, CSK and NEDD8 -Vav1 VAV1 GEF; GEF, Rac/Rho; Motility/polarity/chemotaxis; Oncoprotein P27870 22324 17 D|17 29.76 cM mouse Y541-p 3744041 MLLRGTFyQGYRCYR C1_1 activity, induced 24736456 1 1 3 based on a lower activity of Y->F mutant in Jurkat cells stimulated by anti-CD3 antibody -Ola1 OLA1 EC 3.6.3.-; Hydrolase; Nucleolus Q9CZ30 67059 2|2 C3 mouse T325-p 1880539200 AWTIRKGtKAPQAAG protein stabilization; molecular association, regulation; ubiquitination; enzymatic activity, altered transcription, induced DNA(INDUCES) 36481055 1 1 0 inhibits ubiquitination -Stat1 STAT1 DNA-binding; Transcription factor P42225 20846 1 C1.1|1 26.81 cM mouse Y701-p 447754 DDPKRTGyIKTELIS protein degradation; sumoylation; molecular association, regulation; ubiquitination; intracellular localization; activity, inhibited; phosphorylation carcinogenesis, inhibited; apoptosis, induced; autophagy, inhibited; transcription, induced; transcription, inhibited; cell growth, altered DNA(INDUCES) 11226159; 12640464; 17255531; 17346795; 18574148; 18941537; 21636857; 31896593; 32209571; 33125792; 33504618; 33574087; 33941660; 34303919; 34753772 204 7 64 -CSNK1A1 CK1A EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, CK1; Protein kinase, Ser/Thr (non-receptor) P48729 1452 5q32 human K62-ub 12112130 PQLLYESkLYKILQG Pkinase protein degradation 26909574 1 7 8 -Dzip1 DZIP1 C2H2-type zinc finger protein Q8BMD2 66573 14|14 E4 mouse S210-p 62403301 QRRHTEDsHLEYNTK molecular association, regulation PCM-1(DISRUPTS) 27979967 1 1 0 dissociation of the BBSome from PCM1 and the removal of the BBSome and Dzip1 from the CS at the G2 phase -HSP90AA1 HSP90A Chaperone; Heat shock protein P07900 3320 14q32.31 human K294-ac 486377 QEELNKTkPIWTRNP HSP90 activity, induced; molecular association, regulation cell growth, induced HSP70(DISRUPTS); HER2(DISRUPTS); HOPX(DISRUPTS); FKBP4(DISRUPTS); AR(DISRUPTS); AHSA1(DISRUPTS); CHIP(DISRUPTS); Src(DISRUPTS); CDC37(DISRUPTS); Chk1(DISRUPTS) 17218278 4 3 0 -TP53BP1 53BP1 DNA repair, damage; Transcription, coactivator/corepressor Q12888 7158 15q15.3 human R1403-me 2344818 RGRGRRGrPPSRTTG molecular association, regulation DNA(INDUCES) 16294045 2 0 0 -Npas4 NPAS4 DNA-binding Q8BGD7 225872 19|19 A mouse T423-p 1871095704 LSKDLVCtPPYTPHQ molecular association, regulation neural plasticity; transcription, induced CBP(INDUCES) 31801086 1 1 0 -TP73 p73 DNA-binding; Transcription factor; Tumor suppressor O15350 7161 1p36.32 human T27-p 2063601 SSLEPDStYFDLPQS molecular association, regulation; activity, inhibited transcription, induced; transcription, inhibited DNA(DISRUPTS) 18418051; 25379016 3 0 0 induced-spheroid formation, clonogenicty and side population of CSC genes -PI4KB PIK4CB iso2 Carbohydrate Metabolism - inositol phosphate; EC 2.7.1.67; Kinase, lipid; Motility/polarity/chemotaxis Q9UBF8-2 5298 1q21.3 human T504-p 457624 EQLAHTPtAFKRDPE intracellular localization 16606619 1 2 0 T504-phosphorylated PIK4CB localizes in the nucleus -TSC1 TSC1 Motility/polarity/chemotaxis; Tumor suppressor Q92574 7248 9q34.13 human S579-p 911089200 CQTSLETsIFTPSPC Hamartin intracellular localization cell cycle regulation; cell growth, altered 29559472 1 0 0 decreased lysosomal localization of the TSC complex -GFAP GFAP Cytoskeletal P14136 2670 17q21.31 human S13-p 449619 ITSAARRsYVSSGEM Filament_head molecular association, regulation; protein stabilization; protein processing; intracellular localization fascin(INDUCES) 12177195; 19170683; 31682229 11 5 0 GFAP aggregation induced; promotes GFAP cleavage by caspase-6 -RUVBL1 RUVBL1 EC 3.6.4.12; Helicase; Motility/polarity/chemotaxis Q9Y265 8607 3q21.3 human T239-p 41608704 KEIIQDVtLHDLDVA TIP49 cell cycle regulation 26201077 1 0 0 -PCBP2 hnRNP E2 RNA splicing; RNA-binding Q15366 5094 12q13.13 human T213-p 482919 SASFPHTtPSMCLNP protein stabilization; molecular association, regulation cell differentiation, inhibited; translation, inhibited RNA(INDUCES) 17475908 1 0 0 -PIGR PIGR Immunoglobulin superfamily; Membrane protein, integral; Receptor, misc. P01832 100328593 rabbit S682-p 451431 RRNVDRVsIGSYRTD intracellular localization 8343953 1 8 2 S682 phosphorylation is required for transcytosis of poly-Ig receptor in the absence digA. -GLS glutaminase Amino Acid Metabolism - alanine, aspartate and glutamate; Amino Acid Metabolism - arginine and proline; EC 3.5.1.2; Energy Metabolism - nitrogen; Hydrolase; Mitochondrial; Other Amino Acids Metabolism - D-Glutamine and D-glutamate O94925 2744 2q32.2 human K311-sc 33359373 YVHRYVGkEPSGLRF Glutaminase protein conformation; enzymatic activity, induced carcinogenesis, induced; cell growth, induced GLS2(INDUCES) 33991485 1 2 0 succinylation results in conformational changes, enhanced oligomerization, apoptosis induced by antioxidative stress -ADD1 ADD1 Cytoskeletal; Motility/polarity/chemotaxis P35611 118 4p16.3 human S12-p 481591 SRAAVVTsPPPTTAP molecular association, regulation cytoskeletal reorganization MYO10(INDUCES) 24379415 2 49 0 association with mitotic spindles -Chpt1 CHPT1 EC 2.7.8.2; Lipid Metabolism - ether lipid; Lipid Metabolism - glycerophospholipid; Membrane protein, integral; Membrane protein, multi-pass; Transferase Q8C025 212862 10|10 C1 mouse K307-ub 12718512 MFGCVFAkVAQKLVI TM protein degradation; enzymatic activity, inhibited 20018880 1 0 0 -CALCA CALCA Secreted; Secreted, signal peptide P01258 796 11p15.2 human T105-p 25285789 QDFNKFHtFPQTAIG Calc_CGRP_IAPP protein conformation 33220304 0 1 1 Delay peptide fibril formation -Per2 PER2 Nuclear receptor co-regulator; Nucleolus; Transcription factor Q9Z301 63840 9q36 rat S662-p 470017 GKAESVVsLTSQCSY intracellular localization 35227001 3 1 1 -LATS1 LATS1 EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, AGC; Protein kinase, Ser/Thr (non-receptor); Tumor suppressor O95835 9113 6q25.1 human T1079-p 457595 EHAFYEFtFRRFFDD activity, induced; protein degradation; intracellular localization; enzymatic activity, inhibited; phosphorylation; enzymatic activity, induced cell cycle regulation; carcinogenesis, inhibited; apoptosis, induced; cell growth, inhibited; cell motility, inhibited; transcription, inhibited; signaling pathway regulation 15688006; 24362629; 27847303; 30800215; 31239271; 31792377; 33630828; 34465890; 35307353; 35804016; 37319316 34 1 0 -MORC2 MORC2 DNA-binding Q9Y6X9 22880 22q12.2 human T733-p 3217920 PIKLSPAtPSRKRSV protein degradation; molecular association, regulation cell cycle regulation; carcinogenesis, inhibited; autophagy, induced; cell growth, inhibited; apoptosis, induced LAMP2(INDUCES); HSC70(INDUCES) 36967563 1 10 8 -TAOK1 TAO1 EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, STE; Protein kinase, Ser/Thr (non-receptor) Q7L7X3 57551 17q11.2 human S554-p 3627515 ELNSFLEsQKREYKL cell cycle regulation 17396146 1 0 1 -ULK1 ULK1 Autophagy; EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, Other; Protein kinase, Ser/Thr (non-receptor) O75385 8408 12q24.33 human S317-p 35495300 SHLASPPsLGEMQQL autophagy, induced; cell growth, inhibited; transcription, altered 34604061; 34759263; 34820368 20 1 0 -BIRC5 Survivin Apoptosis O15392 332 17q25.3 human K90-ub 40439805 GCAFLSVkKQFEELT protein degradation 25778398 1 1 0 impairs mitochondrial function -Cgas cGAS EC 2.7.7.86 Q8C6L5 214763 9|9 E1 mouse S420-p 1869388601 QELDAFCsYHVKTAI Mab-21_C molecular association, regulation; protein conformation; enzymatic activity, induced transcription, induced DNA(INDUCES) 32474700 2 0 0 enhances GTP binding -RARG RARG DNA-binding; Nuclear receptor P13631 5916 12q13.13 human S371-p 62884000 YARRRRPsQPYMFPR Hormone_recep activity, induced 31740618 2 0 0 -Rps6kb2 P70S6KB EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, AGC; Protein kinase, Ser/Thr (non-receptor); Translation Q9Z1M4 58988 19|19 A mouse S410-p 455989 SFQPKLRsPRRLNSS phosphorylation 17980619 2 0 3 -H4c2 H4 DNA-binding P62804 295277 rat K12-ac 459013 KGGKGLGkGGAKRHR transcription, induced 19909801 93 25 531 -ARHGEF2 ARHGEF2 GEF; GEF, Rac/Rho; Motility/polarity/chemotaxis Q92974 9181 1q22 human Y198-p 1869121005 IDEAEVIySELMSDF intracellular localization; protein conformation; enzymatic activity, induced cell motility, induced; cytoskeletal reorganization 31420453 1 0 0 induces Rho activation -Atf4 ATF-4 DNA-binding; Transcription factor Q06507 11911 15 E1|15 37.85 cM mouse S218-p 448436 DTPSDNDsGICMSPE protein degradation neural plasticity 33198401 4 0 0 -TSC1 TSC1 Motility/polarity/chemotaxis; Tumor suppressor Q92574 7248 9q34.13 human S511-p 3208191 DSPFYRDsLPGSQRK Hamartin protein degradation; molecular association, regulation; ubiquitination; phosphorylation carcinogenesis, induced; cell growth, induced; signaling pathway regulation TSC2(DISRUPTS) 17693255 4 6 11 induces S6K1 phosphorylation, activates mTOR pathway -Kif3a KIF3A Microtubule-binding; Motor P28741 16568 11 B1.3|11 31.97 cM mouse T694-p 31906433 KRSAKPEtVIDSLLQ activity, induced; molecular association, regulation CDH2(INDUCES) 26335646 1 4 0 enhances N-cadhedrin transport and affects synapse formation -Hist3h2ba H2B DNA-binding D3ZNZ9 303175 10q22 rat S14-p 449904 TPAPKKGsKKAITKA Histone chromatin organization, altered; apoptosis, induced 20057502 10 1 0 -Pde3b PDE3B EC 3.1.4.17; Membrane protein, integral; Membrane protein, multi-pass; Nucleotide Metabolism - purine; Phosphodiesterase Q63085 29516 1q34 rat S279-p 447699 VIRPRRRsSCVSLGE molecular association, regulation 14-3-3 beta(INDUCES) 12453887 4 7 78 -PPP2CA PPP2CA EC 3.1.3.16; Motility/polarity/chemotaxis; PHOSPHATASE; Protein phosphatase, Ser/Thr (non-receptor) P67776 pig Y307-p 448571 VTRRTPDyFL_____ signaling pathway regulation 23799098 73 1 0 simvastatin-induced signaling for the closure of K-ATP channel -CDC25C CDC25C EC 3.1.3.48; Motility/polarity/chemotaxis; PHOSPHATASE; Protein phosphatase, dual-specificity P30307 995 5q31.2 human S191-p 450979 EDQAEEIsDELMEFS M-inducer_phosp intracellular localization 14968113 1 1 1 -Ctnnd1 CTNND1 Actin-binding; Adaptor/scaffold; Cell adhesion; G protein regulator, misc.; Motility/polarity/chemotaxis P30999 12388 2 D|2 49.45 cM mouse K622-ac 3689228 AASCFGAkKGKDEWF cytoskeletal reorganization 16916647 0 1 24 -ITGB2 ITGB2 Cell adhesion; Cell surface; Membrane protein, integral; Motility/polarity/chemotaxis; Receptor, misc. P05107 3689 21q22.3 human T760-p 450185 LFKSATTtVMNPKFA Integrin_b_cyt molecular association, regulation kindlin-3(INDUCES) 23823319 3 0 0 -Gabrb3 GABRB3 Channel, chloride; Channel, ligand-gated; Membrane protein, integral; Membrane protein, multi-pass; Transporter; Transporter, ion channel NP_058761 24922 1q22 rat S384-p 20503435 EMNEVAGsVGDTRNS Neur_chan_memb receptor internalization, induced signaling pathway regulation 30820888 2 1 0 Ca2+/CaMKII-mediated signaling pathway -AP2M1 AP2M1 Adaptor/scaffold; Vesicle Q96CW1 1173 3q27.1 human T156-p 448782 SQITSQVtGQIGWRR activity, induced; molecular association, regulation; intracellular localization endocytosis, induced ATP1A1(NOT_REPORTED) 11877457; 16498080; 33137362; 34315807 9 33 29 -RACK1 RACK1 Adaptor/scaffold; G protein; G protein, heterotrimeric; G protein, heterotrimeric beta; Motility/polarity/chemotaxis; Nuclear receptor co-regulator P63244 10399 5q35.3 human K271-m2 63354300 KIIVDELkQEVISTS molecular association, regulation; ubiquitination HIF1A(DISRUPTS) 28279976 1 1 0 suppresses HIF-1alpha ubiquitination and oxygen-independent degradation, leading to accumulation of HIF-1a -Cad CAD Amino Acid Metabolism - alanine, aspartate and glutamate; EC 2.1.3.2; EC 3.5.2.3; EC 6.3.5.5; Hydrolase; KINASE; Ligase; Nucleotide Metabolism - pyrimidine; Transferase B2RQC6 69719 5|5 B1 mouse S1859-p 451247 PPRIHRAsDPGLPAE carcinogenesis, induced; cell motility, induced; cell growth, induced; apoptosis, inhibited 36122209 11 88 86 -STIM1 STIM1 Calcium-binding; Endoplasmic reticulum; Membrane protein, integral Q13586 6786 11p15.4 human S621-p 3635048 SRSHSPSsPDPDTPS molecular association, regulation; intracellular localization; activity, inhibited; protein conformation; phosphorylation cell motility, induced EB1(DISRUPTS); ORAI1(INDUCES) 25447552; 25562429; 28935720; 33023909 8 11 1 GPER activation to inhibit SOCE; accelerates cell migration in wound-healing assays; NFAT translocation to the nucleus, multimerization; phosphorylation of STIM1 at S621may increase SOCE activity -Usp9x USP9X DEUBIQUITINASE; EC 3.4.19.12; Protease; Ubiquitin conjugating system; Ubiquitin-specific protease P70398 22284 X A1.1|X 7.95 cM mouse S1600-p 467832 SDVDDDMsGDEKQDN UCH enzymatic activity, induced 26936881 1 46 2 -Ubtf UBF DNA-binding; Nucleolus; Transcription factor P25976 21429 11|11 D mouse S484-p 450180 DRGKLPEsPKRAEEI HMG_box_5 transcription, induced 10202152 3 34 60 -RAF1 RAF1 EC 2.7.11.1; KINASE; Kinase, protein; Oncoprotein; Protein kinase, Ser/Thr (non-receptor); Protein kinase, TKL P04049 5894 3p25.2 human S642-p 455309 NACTLTTsPRLPVF_ molecular association, regulation; intracellular localization; enzymatic activity, inhibited HRas(DISRUPTS) 15664191 1 27 23 -HMGN1 HMGN1 DNA-binding; Nuclear receptor co-regulator P05114 3150 21q22.2 human K18-ac 458844 GAAKEEPkRRSARLS HMG14_17 molecular association, regulation DNA(DISRUPTS) 10753971 1 0 6 -AP2B1 AP2B1 Vesicle P63010 163 17q12 human S258-p 178605774 ANSAVVLsAVKVLMK Adaptin_N intracellular localization 31492751 1 1 0 suppresses its nuclear accumulation -CFLAR CFLAR Apoptosis O15519 8837 2q33.1 human S273-p 7590800 LLRDTFTsLGYEVQK Peptidase_C14 protein degradation 19339247 1 0 0 -BLM BLM DNA repair, damage; DNA replication; EC 3.6.4.12; Helicase P54132 641 15q26.1 human K259-ub 28132102 AQESDSLkTHLEDER BLM_N molecular association, regulation; intracellular localization DNA repair, inhibited RAP80(INDUCES) 23708797 1 0 0 -TRPV3 TRPV3 Channel, cation; Membrane protein, integral; Membrane protein, multi-pass Q8NET8 162514 17p13.2 human T264-p 334535805 EGFYFGEtPLALAAC Ank activity, induced 29084846 1 0 0 modulation of TRPV3 channel activity -GPSM3 GPSM3 G protein regulator, misc. Q9Y4H4 63940 6p21.32 human S35-p 4717965 STTRPWRsAPPSPPP protein stabilization; molecular association, regulation; intracellular localization 14-3-3 beta(INDUCES) 22843681 1 24 7 -MAPT Tau iso8 ACETYLTRANSFERASE; Acetyltransferase; Cytoskeletal P10636-8 4137 17q21.31 human S293-p 449327 NVQSKCGsKDNIKHV Tubulin-binding molecular association, regulation 21204788 5 1 0 in vitro microtubule binding -Cebpb C/EBP-beta DNA-binding; Motility/polarity/chemotaxis; Transcription factor P28033 12608 2 H3|2 87.58 cM mouse S181-gl 7789201 SGSLSTSsSSSPPGT molecular association, regulation; phosphorylation cell differentiation, inhibited; transcription, inhibited DNA(DISRUPTS) 19478079 1 1 0 prevents phosphorylation of T179, S184, T188 -SOS1 SOS1 Adaptor/scaffold; GEF; GEF, Ras; Motility/polarity/chemotaxis Q07889 6654 2p22.1 human S1178-p 451315 IMSKHLDsPPAIPPR molecular association, regulation GRB2(DISRUPTS) 8816480 1 18 0 -DDX5 DDX5 EC 3.6.4.13; Helicase; Nuclear receptor co-regulator; Nucleolus; RNA splicing; RNA-binding; Spliceosome P17844 1655 17q23.3 human T564-p 27156800 SFRTGNPtGTYQNGY P68HR apoptosis, induced 23110695 1 0 0 -MCM7 MCM7 DNA replication; EC 3.6.4.12; Motility/polarity/chemotaxis P33993 4176 7q22.1 human S365-p 10027300 LVGGVDQsPRGMKIR MCM cell cycle regulation 23720738 2 6 1 -Traf2 TRAF2 Autophagy; EC 6.3.2.-; Ligase; UBIQUITIN LIGASE; Ubiquitin conjugating system; Ubiquitin ligase P39429 22030 2|2 A3 mouse K21-ub 486265 LLQPGFSkTLLGTRL protein degradation 11909853 1 0 0 -TFAM TFAM DNA-binding; Transcription regulation Q00059 7019 10q21.1 human K76-ac 1883522700 KAQNPDAkTTELIRR molecular association, regulation TOMM70A(DISRUPTS) 36474281 1 0 0 mitochondrial biogenesis impairment -MTA2 MTA2 DEACETYLASE; DNA-binding; Deacetylase; Motility/polarity/chemotaxis; Nuclear receptor co-regulator; Transcription factor O94776 9219 11q12.3 human K32-ub 12363625 RRIEELNkTANGNVE BAH protein degradation 26676607 0 8 5 -Crtc1 TORC1 Transcription factor Q157S1 684527 16p14 rat S215-p 60885604 KAGSRPKsCEVPGIN TORC_M transcription, induced 27903866 1 0 0 neuroprotection against 6-OHDA cytotoxicity -IRF3 IRF3 DNA-binding; Transcription factor Q14653 3661 19q13.33 human S175-p 14567912 PQPLRSPsLDNPTPF molecular association, regulation transcription, inhibited IRF7(INDUCES) 24275658 3 9 0 Formation of IRF3:IRF7 dimers -EYA1 EYA1 Apoptosis; Cell development/differentiation; DNA repair, damage; EC 3.1.3.16; EC 3.1.3.48; Motility/polarity/chemotaxis; PHOSPHATASE; Protein phosphatase, tyrosine (non-receptor) Q99502 2138 8q13.3 human S299-p 41156500 SDRLRRGsDGKSRGR sumoylation cell motility, induced; transcription, induced 24954506 1 0 0 reduces sumoylation -RIC8A RIC8A GEF; GEF, misc. Q9NPQ8 60626 11p15.5 human S502-p 3213318 VIQPMGMsPRGHLTS Ric8 ubiquitination; protein conformation cell cycle regulation 24466196 2 37 2 -HEXIM1 HEXIM1 Motility/polarity/chemotaxis; Transcription factor O94992 10614 17q21.31 human Y271-p 2835700 QRDFSETyERYHTES HEXIM molecular association, regulation; intracellular localization transcription, inhibited; transcription, altered CCNT1(DISRUPTS); CDK9(DISRUPTS); CDK9(INDUCES); LARP7(DISRUPTS) 15965233; 25900325 3 1 0 nuclear localization, inhibits proviral gene expression, inhibition of 7SK snRNP complex aassembly -TP53BP1 53BP1 DNA repair, damage; Transcription, coactivator/corepressor Q12888 7158 15q15.3 human S1219-p 481849 DDTESLHsQGEEEFD cell cycle regulation 18996087 3 19 42 -Scarb1 SCARB1 Membrane protein, integral; Membrane protein, multi-pass; Receptor, misc. P97943 25073 12q15 rat K500-ub 12395920 SLMSPAAkGTVLQEA protein degradation 28669731 1 4 1 -LAMP2 LAMP2 Membrane protein, integral P13473 3920 Xq24 human T213-p 386186606 PSPTTTPtPKEKPEA protein degradation; intracellular localization; protein conformation carcinogenesis, induced; autophagy, induced; cell growth, induced 29176575; 33685990 2 0 0 -FOXC2 FOXC2 Apoptosis; Cell development/differentiation; DNA-binding; Transcription factor Q99958 2303 16q24.1 human T247-p 7322584 SPRSAAStPAGSPDG molecular association, regulation transcription, altered DNA(INDUCES) 23878394 1 1 0 implicated in vascular remodeling in vivo -Arrb2 ARRB2 Adaptor/scaffold Q91YI4 216869 11 B3|11 42.99 cM mouse K107-ub 6140805 RLQDRLLkKLGQHAH Arrestin_N molecular association, regulation mAChR M2(INDUCES); mAChR m1(INDUCES) 19055777 1 0 0 -CEBPB C/EBP-beta DNA-binding; Motility/polarity/chemotaxis; Transcription factor P17676 1051 20q13.13 human S325-p 11180067 EQLSRELsTLRNLFK transcription, induced 1314426 1 0 0 -TOP2A TOP2A EC 5.99.1.3; Isomerase P11388 7153 17q21.2 human T1244-p 3180474 KKIKNENtEGSPQED sumoylation cell cycle regulation 30871006 1 13 0 influences sumoylation of K1240 -Ctnnb1 CTNNB1 Actin-binding; Cell adhesion; Motility/polarity/chemotaxis; Nuclear receptor co-regulator; Oncoprotein; Transcription factor Q02248 12387 9 F4|9 72.19 cM mouse T41-p 447583 GIHSGATtTAPSLSG protein degradation; ubiquitination cell differentiation, inhibited; carcinogenesis, inhibited; cell growth, inhibited; cell motility, inhibited 34642308; 35013220; 9233789 102 3 0 -PTGER4 PTGER4 GPCR, family 1; Membrane protein, integral; Membrane protein, multi-pass; Receptor, GPCR P35408 5734 5p13.1 human S377-p 450696 SSAMSGHsRSFISRE molecular association, regulation ARRB1(INDUCES) 14709160 1 0 0 -H3C1 H3 DNA-binding P68431 8350 6p22.2 human K79-m3 1458614 REIAQDFkTDLRFQS Histone cell cycle regulation; carcinogenesis, induced; cell growth, induced; chromatin organization, altered; cytoskeletal reorganization; transcription, inhibited 19805358; 22190683; 23227340 17 4 0 indicator of mitosis and tumor cell proliferation; regulates chromosome seggregation and cell senescence; regulates nucleosome dynamics -ETS1 Ets-1 DNA-binding; Motility/polarity/chemotaxis; Oncoprotein; Transcription factor P13474 396235 chicken S285-p 449318 QRVPSYDsFDSEDYP Ets1_N_flank activity, inhibited 7961750 6 10 56 The in vitro interaction of Ets-1 with a high-affinity Ets binding site was assayed with EMSA. -Cttn Cortactin Actin-binding; Cytoskeletal; Motility/polarity/chemotaxis Q60598 13043 7|7 F5 mouse Y475-p 3973973 TTEAPGHyQAEDDTY molecular association, regulation cell motility, induced FAK(DISRUPTS) 22078467 1 1 1 -N Nucleocapsid Protein P59595 1489678 SARSCoV1 S203-p 1868174954 RNSTPGSsRGNSPAR CoV_nucleocap molecular association, regulation Nucleocapsid Protein(INDUCES) 23717688 3 3 0 di-domain self-association -Mapk9 JNK2 EC 2.7.11.24; KINASE; Kinase, protein; Protein kinase, CMGC; Protein kinase, Ser/Thr (non-receptor) Q9WTU6 26420 11|11 B1.2-B1.3 mouse T183-p 447649 ACTNFMMtPYVVTRY Pkinase enzymatic activity, induced apoptosis, induced; cell motility, induced; transcription, inhibited 16061178; 18032450; 26306048 72 21 435 GTS sequence motif within the activation loop offers a higher phosphorylation efficiency and therefore functional activation of JNK1 over JNK2.; Fyn and thapsigargin-induced cell death; transcription leading to gene expression, epithelial cell migration and eyelid closure. -SMAD3 SMAD3 DNA-binding; Nuclear receptor co-regulator; Transcription factor P84022 4088 15q22.33 human K117-ac 1881518200 EFAFNMKkDEVCVNP carcinogenesis, induced; transcription, induced 34392614 1 0 0 upregulates immune response-related cytokines, recruits myeloid-derived suppressor cells and promotion of metastasis -NIN NIN Cytoskeletal; Microtubule-binding Q8N4C6 51199 14q22.1 human K1641-sm 12004428 EQEKFNLkEELERCK intracellular localization 16154161 1 0 0 -SCFD1 SCFD1 Vesicle Q8WVM8 23256 14q12 human S303-p 3207654 ESSGVENsPAGARPK Sec1 molecular association, regulation autophagy, induced PCAF(DISRUPTS) 35465820 1 67 17 SCFD1 phosphorylation promotes its deacetylation -AGAP2 CENTG1 iso2 GAP; GAP, ARF; Motility/polarity/chemotaxis; Tumor suppressor Q99490-2 116986 12q14.1 human Y774-p 467225 QGRTALFyARQAGSQ Ank_2 molecular association, regulation; protein stabilization apoptosis, altered; cell growth, induced AMPKA2(INDUCES) 16841086; 26001218 2 0 0 -ABL1 Abl iso2 EC 2.7.10.2; KINASE; Kinase, protein; Oncoprotein; Protein kinase, TK; Protein kinase, tyrosine (non-receptor) P00519-2 25 9q34.12 human Y488-p 450295 EGCPEKVyELMRACW PK_Tyr_Ser-Thr molecular association, regulation; phosphorylation apoptosis, inhibited MIG-6(DISRUPTS) 22975324 2 4 287 inhibits Mig6-dependent proapoptotic activation, inhibits Abl phosphorylation -AGAP2 CENTG1 iso2 GAP; GAP, ARF; Motility/polarity/chemotaxis; Tumor suppressor Q99490-2 116986 12q14.1 human S629-p 4719772 THLSRVRsLDLDDWP ArfGap molecular association, regulation; enzymatic activity, induced cell growth, altered NFkB-p105(INDUCES) 19176382 1 3 0 enhances proliferation , foci formation, and tumor progression in prostate cancer cells -Brsk2 BRSK2 EC 2.7.11.1; EC 2.7.11.26; KINASE; Kinase, protein; Protein kinase, CAMK; Protein kinase, Ser/Thr (non-receptor) Q69Z98 75770 7|7 F5 mouse T432-p 17551645 PLSSPRVtPHPSPRG protein stabilization; enzymatic activity, inhibited; phosphorylation 23790753 1 3 0 inhibits axon branching (activated in BRSK2 18A mutant) -PTTG1 Securin Cell cycle regulation; Oncoprotein O95997 9232 5q33.3 human K48-ub 12718508 VSTPRFGkTFDAPPA Securin protein degradation 20080579 1 3 0 -Dpysl3 CRMP-4 Hydrolase Q62952 25418 18p11-q11 rat T509-p 454328 PVFDLTTtPKGGTPA molecular association, regulation TUBB3(DISRUPTS); SLC25A5(DISRUPTS); CRMP-2(DISRUPTS); CRMP-1(DISRUPTS); PIN1(INDUCES); SLC25A4(DISRUPTS); DYRK1A(DISRUPTS) 18220421 3 50 16 -SOX9 SOX9 DNA-binding; Transcription factor P48436 6662 17q24.3 human S181-p 456981 YQPRRRKsVKNGQAE activity, induced; molecular association, regulation; intracellular localization carcinogenesis, induced; cell motility, induced; cell differentiation, induced; transcription, induced; cytoskeletal reorganization; signaling pathway regulation KPNB1(INDUCES) 10805756; 15889150; 19470758; 20039424; 21818404; 32277958 12 2 0 ADCK5-SOX9-PTTG1 pathway; increased migration of cancer cells -SMARCAL1 SMARCAL1 EC 3.6.1.-; EC 3.6.4.-; Helicase Q9NZC9 50485 2q35 human S123-p 29606711 QMALTGIsPPLAQSP protein degradation 30996091 1 9 0 -ADRB2 ADRB2 GPCR, family 1; Membrane protein, integral; Membrane protein, multi-pass; Receptor, GPCR P07550 154 5q32 human Y132-p 449831 CVIAVDRyFAITSPF 7tm_1 activity, induced 17925438 3 0 0 G-protein activation -TTI1 TTI1 DNA repair, damage O43156 9675 20q11.23 human S828-p 9765114 DVADGNVsDFDNEEE protein degradation; molecular association, regulation; ubiquitination; enzymatic activity, induced; phosphorylation cell growth, induced; signaling pathway regulation; translation, inhibited DNAPK(INDUCES); ATM(INDUCES); FBXO9(INDUCES) 23263282; 24657168 2 12 1 mutation of site S828 increase phosphorylation of S6K1 and S6, mediates mTORC1 signaling -Xiap XIAP Apoptosis; EC 6.3.2.-; Ligase; UBIQUITIN LIGASE; Ubiquitin conjugating system; Ubiquitin ligase Q60989 11798 X|X A4 mouse S87-p 450336 VGRHRRIsPNCRFIN BIR protein stabilization cell growth, induced 25686839 10 0 0 -CREBBP CBP ACETYLTRANSFERASE; Acetyltransferase; DNA-binding; EC 2.3.1.48; Motility/polarity/chemotaxis; Nuclear receptor co-regulator; Transcription, coactivator/corepressor Q92793 1387 16p13.3 human Y1125-p 55377870 QLLGIPDyFDIVKNP Bromodomain cell differentiation, induced; signaling pathway regulation 30573679 1 2 0 regulates T-cell responses to infection, cytokine signaling pathway -NFE2L2 NRF2 DNA-binding; Transcription factor Q16236 4780 2q31.2 human S433-p 27461383 PEKELPVsPGHRKTP activity, induced; protein degradation; protein stabilization; molecular association, regulation; ubiquitination; intracellular localization transcription, induced; transcription, inhibited; signaling pathway regulation BTRC(INDUCES); FBW1B(INDUCES) 25909891; 31805502; 37627580 3 6 0 -Prkca PKCA EC 2.7.11.13; KINASE; Kinase, protein; Oncoprotein; Protein kinase, AGC; Protein kinase, Ser/Thr (non-receptor) P05696 24680 10q32.1 rat T497-p 448598 MDGVTTRtFCGTPDY Pkinase activity, induced 25477822 7 48 62 -KHDRBS1 KHDRBS1 RNA-binding Q07666 10657 1p35.2 human T328-p 1884166700 GAITRGAtVTRGVPP neural plasticity; RNA splicing, induced 37595869 1 0 0 -Pex14 PEX14 Adaptor/scaffold Q642G4 64460 5q36 rat S232-p 455420 NRRQFPPsPSAPKIP molecular association, regulation; intracellular localization; protein conformation PEX13(INDUCES); Catalase(DISRUPTS); PEX14(INDUCES) 32831175; 32854114 2 20 86 -FAS FAS Apoptosis; Cell surface; Membrane protein, integral; Receptor, cytokine P25445 355 10q23.31 human Y232-p 455221 SDVDLSKyITTIAGV Death molecular association, regulation; intracellular localization apoptosis, altered FAS(INDUCES); FADD(INDUCES); CASP8(INDUCES) 15660394; 17195092 2 0 0 Y232 or Y291 is required for Fas oligomerization -APOBEC3G APOBEC3G EC 3.5.4.-; Hydrolase; RNA processing; RNA-binding Q9HC16 60489 22q13.1 human T32-p 5044101 PILSRRNtVWLCYEV NAD2 activity, induced; molecular association, regulation; protein conformation 18836454 2 1 0 promotes APOBEC3G anti-viral activity, by inhibiting binding to HIV-1 viral infectivity factor and its subsequent ubiquitination and degradation -SCN5A SCN5A Channel, sodium; Membrane protein, integral; Membrane protein, multi-pass Q14524 6331 3p22.2 human K442-sm 1877008700 QEAMEMLkKEHEALT activity, induced 32075761 0 1 0 action potential prolongation -RARG RARG DNA-binding; Nuclear receptor P13631 5916 12q13.13 human S77-p 455543 SEEMVPSsPSPPPPP activity, induced transcription, induced 10748061 2 0 0 Transactivation of mRARb2 promoter -TRAIP TRAIP EC 6.3.2.-; Ligase; Nucleolus; UBIQUITIN LIGASE; Ubiquitin conjugating system; Ubiquitin ligase Q9BWF2 10293 3p21.31 human K462-sm 53529102 VPSLFQAkLDTFLWS protein stabilization; ubiquitination; intracellular localization 26820530 1 0 0 inhibits ubiquitination -OCLN occludin Cell adhesion; Membrane protein, integral; Membrane protein, multi-pass; Motility/polarity/chemotaxis Q16625 100506658 5q13.2 human S408-p 2906719 DYTTGGEsCDELEED molecular association, regulation; intracellular localization ZO1(DISRUPTS); occludin(DISRUPTS); occludin(INDUCES); Claudin-1(DISRUPTS); ZO2(DISRUPTS); Claudin-2(DISRUPTS) 21536752; 23758859 3 10 6 homo dimerization of occludin; . Phosphorylation affects occludin solubility and regulates assembly/disassembly of TJ proteins -EIF4EBP2 4E-BP2 Translation; Translation initiation Q13542 1979 10q22.1 human T46-p 449410 GGTLFSTtPGGTRII eIF_4EBP molecular association, regulation; protein conformation 4E-BP1(DISRUPTS) 25533957 4 25 70 -RBL2 Rb-like 2 Transcription, coactivator/corepressor; Tumor suppressor Q08999 5934 16q12.2 human S1035-p 449738 NMDAPPLsPYPFVRT molecular association, regulation cell cycle regulation; transcription, induced E2F4(DISRUPTS) 11157749; 12006580; 28289097 4 8 27 -H3C1 H3 DNA-binding P68431 8350 6p22.2 human K27-m3 1308913 LATKAARkSAPATGG Histone molecular association, regulation; ubiquitination; methylation; intracellular localization cell cycle regulation; carcinogenesis, induced; apoptosis, induced; cell motility, induced; cell adhesion, inhibited; signaling pathway regulation; cell growth, induced; transcription, inhibited; cell differentiation, inhibited; carcinogenesis, inhibited; cell growth, inhibited; transcription, induced; transcription, altered; DNA repair, induced; cell differentiation, induced; chromatin organization, altered; cytoskeletal reorganization H2AFV(INDUCES); CDYL2(INDUCES); RCOR1(DISRUPTS); CDYL(INDUCES); H2AZ(INDUCES) 15525528; 17589499; 18628788; 18931660; 19473514; 19477956; 19503595; 19523850; 19717977; 19883641; 20003410; 20033197; 20053926; 20152814; 20159609; 20385584; 20473313; 20543557; 20546607; 20547755; 20850016; 21059703; 21282660; 22897849; 22899583; 23238014; 23273982; 23328481; 23423141; 23772023; 23826380; 23893242; 24474760; 25605023; 25955299; 26263556; 27151441; 28751304; 28754676; 29371934; 31015297; 35184652; 35322029; 35694846; 36060800; 36165173; 36220978; 36461911 195 24 3 -ESR1 ER-alpha DNA-binding; Nuclear receptor; Transcription factor P03372 2099 6q25.1-q25.2 human K303-ub 1873286918 LMIKRSKkNSLALSL protein stabilization 29100376 1 0 0 -SMAD3 SMAD3 DNA-binding; Nuclear receptor co-regulator; Transcription factor P84022 4088 15q22.33 human S213-p 451180 NLSPNPMsPAHNNLD intracellular localization cell cycle regulation; signaling pathway regulation; transcription, inhibited; transcription, altered; cell growth, altered 10197981; 15241418; 20736297; 34360888 13 0 0 inhibits TGF-B signaling -PHB1 PHB Apoptosis; Cell cycle regulation; Chaperone; Mitochondrial; Motility/polarity/chemotaxis; Nuclear receptor co-regulator; Oncoprotein; Transcription, coactivator/corepressor P35232 5245 17q21.33 human Y259-p 6374000 SRSRNITyLPAGQSV O-GlcNAc glycosylation; protein stabilization; molecular association, regulation; intracellular localization; phosphorylation carcinogenesis, induced; cell motility, induced; transcription, induced; signaling pathway regulation NOTCH3(INDUCES); RAF1(INDUCES) 19238206; 22410782; 25575814; 32169072 5 2 0 induces phosphorylation at T258, NOTCH3 stabilization, PBX1 and ABCG2 transcription, induces NOTCH3/PBX1 and B-catenin/ABCG2 signaling pathway; induces ERK phosphorylation and modulates Ras phosphorylation; PIP3 induced migration/invasion, colonization/ metastasis -Sln sarcolipin Endoplasmic reticulum; Membrane protein, integral Q9CQD6 66402 9|9 A5.3 mouse T5-p 459214 ___MERStQELFINF Sarcolipin molecular association, regulation; enzymatic activity, altered SERCA2(INDUCES) 16461894; 25671318 6 0 0 sarcolipin T5A mutant results in abnormal Ca2+ handling and subsequent cardiac remodeling and dysfunction -RAF1 RAF1 EC 2.7.11.1; KINASE; Kinase, protein; Oncoprotein; Protein kinase, Ser/Thr (non-receptor); Protein kinase, TKL P05625 396245 chicken S339-p 447743 PRGQRDSsYYWEIEA intracellular localization apoptosis, inhibited 12843393 9 1 1 -NKX3-1 NKX3-1 DNA-binding; Transcription factor; Tumor suppressor Q99801 4824 8p21.2 human T93-p 464288 EAETLAEtEPERHLG protein stabilization 16581776 2 0 0 -CSNK1E CK1E EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, CK1; Protein kinase, Ser/Thr (non-receptor) P49674 1454 22q13.1 human T337-p 453419 PGPPTGAtANRLRSA enzymatic activity, inhibited 10542239; 12223474 2 0 0 some subset of these 8 sites -Tppp TPPP Cytoskeletal Q7TQD2 72948 13|13 C1 mouse T161-p 10273222 TKAVSSPtVSRLTDT p25-alpha cytoskeletal reorganization 25456499 1 3 0 spine development -Jak2 JAK2 EC 2.7.10.2; KINASE; Kinase, protein; Oncoprotein; Protein kinase, TK; Protein kinase, tyrosine (non-receptor) Q62120 16452 19 C1|19 23.73 cM mouse Y868-p 470141 GSVEMCRyDPLQDNT PK_Tyr_Ser-Thr enzymatic activity, induced 20304997 4 2 0 -Trpm8 TRPM8 Channel, cation; Membrane protein, integral; Membrane protein, multi-pass Q8R4D5 171382 1|1 D mouse S29-p 1874485104 RTLYSSVsRSTDVSY intracellular localization; activity, inhibited 34446569 1 1 0 -MALT1 MALT1 Adaptor/scaffold; Apoptosis; EC 3.4.22.-; Ligase; Nuclear export; Protease; UBIQUITIN LIGASE; Ubiquitin conjugating system Q9UDY8 10892 18q21.32 human K665-ub 2134703 LVSKDLPkHCLYTRL MALT1_Ig protein degradation; molecular association, regulation IKKA(INDUCES) 17948050 1 1 0 activation of NF-kB pathway and IL-2 induction -GRK1 GRK1 EC 2.7.11.14; KINASE; Kinase, protein; Protein kinase, AGC; Protein kinase, Ser/Thr (non-receptor) Q15835 6011 13q34 human S21-p 456353 AFIAARGsFDGSSSQ enzymatic activity, inhibited 15946941 4 1 1 reaction in vitro -Trpm7 ChaK1 Channel, cation; EC 2.7.11.1; KINASE; Kinase, protein; Membrane protein, integral; Membrane protein, multi-pass; Protein kinase, Ser/Thr (non-receptor); Protein kinase, atypical Q923J1 58800 2|2 F1 mouse S1511-p 455463 EDSPEVDsKAALLPD molecular association, regulation RHOA(INDUCES) 31844251 4 4 1 -BRCA1 BRCA1 EC 6.3.2.-; Nuclear receptor co-regulator; Transcription, coactivator/corepressor; Tumor suppressor; UBIQUITIN LIGASE; Ubiquitin conjugating system; Ubiquitin ligase P38398 672 17q21.31 human S1143-p 767900 PMGSSHAsQVCSETP intracellular localization 17531442 2 0 0 S1143 and S1280 phosphorylation contributes to BRCA1 recruitment to MMTS-induced foci. -Slc12a3 NCCT Membrane protein, integral; Membrane protein, multi-pass; Transporter; Transporter, SLC family P55018 54300 19p13-p12 rat T58-p 469617 LRTFGYNtIDVVPAY AA_permease_N activity, induced; ubiquitination; intracellular localization; receptor internalization, inhibited 20445498; 22415098; 22966159; 24668812 25 3 0 ubiquitination reduced -Myo3b MYO3B Actin-binding; EC 2.7.11.1; KINASE; Kinase, protein; Motor; Protein kinase, STE; Protein kinase, Ser/Thr (non-receptor) Q1EG27 329421 2|2 C2 mouse T918-p 36841908 TTNMKRQtMASYFRY Myosin_head enzymatic activity, induced 21895655 1 1 0 -Nfkbie IkB-epsilon DNA-binding; Inhibitor O54910 18037 17|17 B3 mouse S22-p 455581 QCDSGIEsLRSLRSL protein degradation 10497169 2 0 0 -Lpin1 LPIN1 EC 3.1.3.4; Phosphatase, lipid Q91ZP3 14245 12 A1.1|12 7.9 cM mouse K629-sm 10902805 LGLATRIkHESSSSD intracellular localization transcription, induced 19753306 1 0 0 -PSEN1 PSEN1 Cell surface; EC 3.4.23.-; Membrane protein, integral; Membrane protein, multi-pass; Mitochondrial; Protease P49768 5663 14q24.2 human S357-p 448563 PHRSTPEsRAAVQEL Presenilin molecular association, regulation; intracellular localization; protein conformation cell growth, altered CTNNB1(DISRUPTS); CDH2(DISRUPTS); CTNNB1(INDUCES) 11104755; 17360711; 17389597 3 1 10 GSK3beta activation downregulates PI3K/Akt signaling probably by reducing the interaction of PSEN1 with N-cadherin (CDH2)/ beta catenin (CTNNB1); reduced interaction was observed in the constitutively active GSK3beta (S9A) mutant; stabilizes beta catenin by reducing its ubiquitination and turn-over -GTF2I GTF2I DNA-binding; Transcription, coactivator/corepressor P78347 2969 7q11.23 human K221-sm 40724403 SCGPIKVkTEPTEDS molecular association, regulation carcinogenesis, induced; cell growth, induced HDAC3(DISRUPTS) 25869096 1 3 0 -TAOK2 TAO2 Apoptosis; EC 2.7.11.1; KINASE; Kinase, protein; Membrane protein, integral; Membrane protein, multi-pass; Protein kinase, STE; Protein kinase, Ser/Thr (non-receptor) Q9UL54 9344 16p11.2 human S181-p 7447419 SIMAPANsFVGTPYW Pkinase intracellular localization apoptosis, induced 17158878 1 2 1 -FNIP1 FNIP1 Q8TF40 96459 5q31.1 human S941-p 4734327 PRNESSDsALGDSES protein stabilization; molecular association, regulation signaling pathway regulation HSP90A(INDUCES) DNA(INDUCES) 30699359 1 2 0 -Ptk2 FAK EC 2.7.10.2; KINASE; Kinase, protein; Protein kinase, TK; Protein kinase, tyrosine (non-receptor) O35346 25614 7q34 rat K152-sm 2793927 NFFYQQVkSDYMLEI FERM_M phosphorylation 14500712 2 0 0 FAK autophosphorylation -MEF2C MEF2C DNA-binding; Transcription factor Q06413 4208 5q14.3 human K119-ac 12674412 ESEDKYRkINEDIDL HJURP_C molecular association, regulation cell differentiation, induced; transcription, induced MRF(INDUCES) DNA(INDUCES) 15831463 1 0 0 -RIT1 RIT1 G protein; G protein, monomeric; G protein, monomeric, Ras Q92963 6016 1q22 human S209-p 6424741 SVWKRLKsPFRKKKD molecular association, regulation; intracellular localization P311(DISRUPTS); Mad2(DISRUPTS) 34237269 1 4 1 regulates MAD2 dimerization by binding to MAD2 -DGCR8 DGCR8 Nucleolus; RNA processing; RNA-binding Q8WYQ5 54487 22q11.21 human S95-p 3208089 DPNCSGHsPRTARHA protein stabilization 24239349 1 31 2 -Glra1 GLRA1 Membrane protein, integral; Membrane protein, multi-pass; Transporter; Transporter, ion channel Q64018 14654 11 B1.3|11 33.12 cM mouse S408-p 1869137000 PPPAPSKsPEEMRKL molecular association, regulation; ubiquitination neural plasticity; endocytosis, induced EPS15(INDUCES) 31433808 2 1 0 -YAP1 YAP1 iso3 Oncoprotein; Transcription, coactivator/corepressor P46937-3 10413 11q22.1 human Y394-p 54390605 QQNRFPDyLEAIPGT activity, induced; molecular association, regulation; intracellular localization carcinogenesis, induced; cell growth, induced; transcription, induced TEAD1(INDUCES) 27013234 2 0 0 -PHLPP1 PHLPP EC 3.1.3.16; PHOSPHATASE; Protein phosphatase, Ser/Thr (non-receptor); Tumor suppressor O60346 23239 18q21.33 human S324-p 31871709 SPAPSDSsPGEPFVG cell cycle regulation 33397691 1 2 0 -CLASP2 CLASP2 Cytoskeletal; Motility/polarity/chemotaxis O75122 23122 3p22.3 human S1027-p 7320226 NPYNYSDsISPFNKS cell cycle regulation 23045552 1 5 2 -RAB11FIP1 RAB11FIP1 iso3 Vesicle Q6WKZ4-3 80223 8p11.23 human S234-p 4691719 QKTPLSQsMSVLPTS intracellular localization cytoskeletal reorganization 28396819 1 23 1 -SRSF10 SRSF10 RNA splicing; RNA-binding O75494 10772 1p36.11 human S133-p 453583 RRRSRSRsFDYNYRR molecular association, regulation hnRNP K(INDUCES); hnRNP F(INDUCES) 27851963 1 83 29 -LSM4 LSM4 RNA-binding; Spliceosome Q9Y4Z0 25804 19p13.11 human R90-m2 15381290 VVAKGRGrGGLQQQK molecular association, regulation SMN(INDUCES) 11720283 1 2 1 -JAK3 JAK3 EC 2.7.10.2; KINASE; Kinase, protein; Protein kinase, TK; Protein kinase, tyrosine (non-receptor) P52333 3718 19p13.11 human Y939-p 2197000 QICKGMEyLGSRRCV PK_Tyr_Ser-Thr molecular association, regulation; phosphorylation; enzymatic activity, induced STAT5A(INDUCES) 18250158 1 0 0 possible docking site for kinase substrates; required for STAT5A Y694 phosphorylation and its further transcriptional activation -SLC4A4 SLC4A4 Membrane protein, integral; Membrane protein, multi-pass; Transporter; Transporter, SLC family Q9Y6R1 8671 4q13.3 human T49-p 13194700 RRRHKRKtGHKEKKE activity, induced 12730338 2 0 0 S1026 phosphorylation alters stoichiometry shift, while T49 mediates increase in membrane conductance. -Pip4p1 TMEM55B EC 3.1.3.78; Hydrolase; Membrane protein, integral; Membrane protein, multi-pass Q3TWL2 219024 14|14 C1 mouse S76-p 4717517 GEDPPPYsPLTSPDS Tmemb_55A intracellular localization 31329883 1 1 0 -GRIN2B NMDAR2B Channel, calcium; Channel, ligand-gated; Membrane protein, integral; Membrane protein, multi-pass Q13224 2904 12p13.1 human S1303-p 450171 NKLRRQHsYDTFVDL NMDAR2_C activity, induced; receptor desensitization, inhibited; molecular association, regulation; phosphorylation CAMK2A(INDUCES); CAMK2A(DISRUPTS); DAPK1(INDUCES) 19453375; 21423658; 21768120; 25434386; 27998718; 28614711 48 14 31 -BLVRA BVR Cofactor and Vitamin Metabolism - porphyrin and chlorophyll; EC 1.3.1.24; KINASE; Kinase, protein; Oxidoreductase; Protein kinase, Ser/Thr (non-receptor) P53004 644 7p13 human Y198-p 455758 EERKEDQyMKMTVCL Biliv-reduc_cat enzymatic activity, induced 15870194 1 0 1 phosphorylation enhances BVR's antagonism of insulin-stimulated glucose uptake. -PTPRT PTPRT iso1 EC 3.1.3.48; Membrane protein, integral; Motility/polarity/chemotaxis; PHOSPHATASE; Receptor protein phosphatase, tyrosine O14522-1 11122 20q12-q13.11 human Y915-p 11315001 GYGFKEEyEALPEGQ molecular association, regulation; enzymatic activity, inhibited cell growth, altered PTPRT iso1(INDUCES); NLGN1(DISRUPTS) 19816407 1 0 0 attenuates synapse formation -RUNX3 AML2 DNA-binding; Transcription factor Q13761 864 1p36.11 human K171-ac 57676501 ATYHRAIkVTVDGPR Runt molecular association, regulation apoptosis, induced; transcription, induced; signaling pathway regulation BRD2(INDUCES) 24229708 1 0 0 induces p14-p53 pathway -DEF6 DEF6 GEF; GEF, Rac/Rho Q9H4E7 50619 6p21.31 human Y210-p 25687500 SMAIHEVyQELIQDV molecular association, regulation; intracellular localization; protein conformation DCP1A(INDUCES) 22829599 1 0 0 cytoplasmic granule formation -CCNB1 CCNB1 Activator; Cell cycle regulation P14635 891 5q13.2 human S147-p 448446 EDLCQAFsDVILAVN intracellular localization DNA(INDUCES) 11242082; 20117088; 22726437 7 1 0 The phosphorylation of S133 and S147 is necessary for the nuclear translocation of cyclin B1 during G2/M phase.; enhances nuclear import -Celf2 CELF2 iso3 RNA-binding Q792H5-3 29428 17q12.3 rat Y39-p 1870336227 LKELFEPyGAVYQIN RRM_1 molecular association, regulation RNA(INDUCES) 17855367 1 0 0 -IFNAR2 IFNAR2 Membrane protein, integral; Receptor, cytokine P48551 3455 21q22.11 human Y337-p 3063305 PRTSGGGyTMHGLTV activity, induced; molecular association, regulation; phosphorylation transcription, induced; signaling pathway regulation; transcription, altered STAT2(DISRUPTS) 11682488; 12105218; 20038197; 34813358 5 0 0 STAT phosphorylation and activation; lack of STAT1, 2, 3 phosphorylation in IFNAR2 Y337/512F mutant; induces STAT phosphorylation and signaling; IFN induced STAT activation and induced transcription -SCAMP3 SCAMP3 Membrane protein, integral; Membrane protein, multi-pass; Vesicle O14828 10067 1q22 human Y35-p 451850 QHRPSRQyATLDVYN molecular association, regulation EGFR(INDUCES) 33850265 1 12 206 -Nsf NSF Adaptor/scaffold; Autophagy; EC 3.6.4.6; Protease; Vesicle P46460 18195 11 E1|11 67.54 cM mouse S460-p 15794301 MNRHIKAsTKVEVDM AAA_lid_3 intracellular localization; enzymatic activity, induced 20962217 1 0 0 -PAPOLA PAP-alpha EC 2.7.7.19; RNA processing; RNA splicing; Transferase P51003 10914 14q32.2 human K663-sm 2586343 HKEESPKkTKTEEDE protein stabilization; intracellular localization; enzymatic activity, inhibited 18281463 1 0 0 -JAK1 JAK1 EC 2.7.10.2; KINASE; Kinase, protein; Protein kinase, TK; Protein kinase, tyrosine (non-receptor) P23458 3716 1p31.3 human S515-p 62372200 SLHGSDRsFPSLGDL molecular association, regulation 27919027 1 0 0 -SP1 SP1 C2H2-type zinc finger protein; DNA-binding; Transcription factor P08047 6667 12q13.13 human T640-gl 5262501 CGKVYGKtSHLRAHL zf-C2H2 transcription, induced 18513490 2 1 0 -XIAP XIAP Apoptosis; EC 6.3.2.-; Ligase; UBIQUITIN LIGASE; Ubiquitin conjugating system; Ubiquitin ligase P98170 331 Xq25 human T180-p 3801500 WPDYAHLtPRELASA BIR ubiquitination; enzymatic activity, induced TLE3(INDUCES) 29678905 1 3 1 required for the full activity of XIAP in the Wnt pathway, but not in the apoptotic pathway -Hnf4a HNF4 alpha DNA-binding; Nuclear receptor; Transcription factor P49698 15378 2 H3|2 84.32 cM mouse S143-p 458369 RISTRRSsYEDSSLP molecular association, regulation DNA(DISRUPTS) 28039934 4 3 12 bile acid biosynthesis -RPS20 RPS20 Ribosomal; Translation P60866 6224 8q12.1 human K8-ub 486915 MAFKDTGkTPVEPEV translation, altered 32324387 1 13 143 translational read-through of poly(A) mRNA sequence (KAAA) 20, ZNF598 plays a role in this process -STARD3 STARD3 Membrane protein, integral; Membrane protein, multi-pass Q14849 10948 17q12 human S209-p 12738027 LSEGQFYsPPESFAG MENTAL activity, induced; molecular association, regulation VAPA(INDUCES); VAPB(INDUCES); MOSPD2(INDUCES) 33124732; 35231443 2 4 0 -SLC6A3 DAT Membrane protein, integral; Membrane protein, multi-pass; Transporter; Transporter, SLC family Q01959 6531 5p15.33 human S2-p 451135 ______MsKSKCSVG activity, induced 16908408 2 0 0 stimulates DAT-mediated efflux of dopamine -ADRA1D ADRA1D GPCR, family 1; Membrane protein, integral; Membrane protein, multi-pass; Receptor, GPCR P25100 146 20p13 human S300-p 1424270001 KRERGKAsEVVLRIH 7tm_1 receptor internalization, altered signaling pathway regulation 29551601 1 1 0 regulates ERK signaling pathway, induces calcium signaling de-sensitization -IKBKG IKKG Adaptor/scaffold; Protein kinase, regulatory subunit Q9Y6K9 8517 Xq28 human K309-sm 2255103 KAQADIYkADFQAER CC2-LZ molecular association, regulation; intracellular localization apoptosis, inhibited; transcription, induced ATM(INDUCES) 14651848; 16906147; 18583959; 20065354 5 0 0 -Sod1 SOD1 Apoptosis; EC 1.15.1.1; Mitochondrial; Nuclear receptor co-regulator; Oxidoreductase P08228 20655 16 C3.3|16 51.56 cM mouse K123-ac 11317132 RTMVVHEkQDDLGKG Sod_Cu intracellular localization 28066183 2 8 2 -FAS FAS Apoptosis; Cell surface; Membrane protein, integral; Receptor, cytokine P25445 355 10q23.31 human Y91-p 473547 PCQEGKEyTDKAHFS TNFR_c6 intracellular localization apoptosis, altered 17195092 2 0 0 -PGK1 PGK1 Carbohydrate Metabolism - glycolysis and gluconeogenesis; EC 2.7.2.3; KINASE; Kinase, other P00558 5230 Xq21.1 human T243-p 2525475 IGGGMAFtFLKVLNN PGK molecular association, regulation; enzymatic activity, altered carcinogenesis, induced; cell growth, induced PDK1(INDUCES) 30029001 2 1 0 interaction increased by IL-6, and conditioned medium (CM) of THP-1 cells or M2 macrophages -PPARG PPAR-gamma DNA-binding; Nuclear receptor; Transcription factor P37231 5468 3p25.2 human Y102-p 9256871 YDLKLQEyQSAIKVE PPARgamma_N protein stabilization; ubiquitination cell differentiation, induced; transcription, induced PGC-1 alpha(INDUCES) 25368164 2 0 1 inhibits ubiquitination -Stat1 STAT1 DNA-binding; Transcription factor P42225 20846 1 C1.1|1 26.81 cM mouse R31-m1 476759 DSFPMEIrQYLAQWL STAT_int molecular association, regulation transcription, induced PIAS1(DISRUPTS); PTPN2(INDUCES) 12171910 2 0 0 modulates the duration of STAT1 Y701 phosphorylation -SGK3 SGK3 EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, AGC; Protein kinase, Ser/Thr (non-receptor) Q96BR1 23678 8q13.1 human S486-p 448196 DDAFVGFsYAPPSED Pkinase_C molecular association, regulation; enzymatic activity, induced ITCH(INDUCES); PDK1(INDUCES) 14604990; 16888620 5 0 0 CISK interaction with ITCH inhibits CXCR4 degradation. -XRCC5 Ku80 DNA-binding; EC 3.6.1.-; EC 3.6.4.-; Helicase; Nuclear receptor co-regulator; Nucleolus; RNA-binding P13010 7520 2q35 human K334-ub 12398993 DEEQMKYkSEGKCFS Ku molecular association, regulation DNA repair, induced DNA(DISRUPTS) 27895153 1 0 1 -Nr2c1 NR2C1 DNA-binding; Nuclear receptor Q505F1 22025 10 C2|10 48.81 cM mouse K238-sm 4258801 NIHPSGIkTEPAMLM activity, inhibited transcription, altered 18682553 2 0 0 -POLR2A POLR2A EC 2.7.7.48; EC 2.7.7.6; Nucleotide Metabolism - purine; Nucleotide Metabolism - pyrimidine; Transcription initiation complex; Transferase P24928 5430 17p13.1 human K1268-ub 21181946 IMNSDENkMQEEEEV RNA_pol_Rpb1_5; RNA_pol_Rpb1_7 intracellular localization DNA repair, induced; transcription, induced 32142649; 34108663; 34526721 3 8 0 ATPase activity to push Pol II backward and enable DNA repair, Pol II may resume transcription after DNA repair -FIRRM FIRRM Q9NSG2 55732 1q24.2 human S744-p 50774549 ETKNKVVsFLEKTGF molecular association, regulation PPP1CC(DISRUPTS) 34260926 1 3 0 -IRS4 IRS4 Adaptor/scaffold O14654 8471 Xq22.3 human S859-p 36276295 KDAASKPsGEGSFSK protein degradation; molecular association, regulation; ubiquitination carcinogenesis, altered; cell growth, inhibited; signaling pathway regulation CHIP(INDUCES) 30026872 1 1 0 -UBA52 UBA52 Ribosomal; Translation P62987 7311 19p13.11 human S65-p 9765474 DYNIQKEsTLHLVLR ubiquitin molecular association, regulation; protein conformation autophagy, induced UBA52(DISRUPTS) 36205098; 36469690 3 10 0 induces mitophagy -SKP1 SKP1A Cell cycle regulation; Ubiquitin conjugating system P63208 6500 5q31.1 human T131-p 4785800 ANMIKGKtPEEIRKT Skp1 protein degradation; molecular association, regulation; ubiquitination; intracellular localization 14-3-3 sigma(INDUCES) 30728155 1 32 2 14-3-3 sigma compete with FBW7 for binding with SKP1A; effect of protein function is interaction dependent -SLC9A1 NHE1 Membrane protein, integral; Membrane protein, multi-pass; Motility/polarity/chemotaxis; Transporter; Transporter, SLC family P19634 6548 1p36.11 human T779-p 3914103 PGTDDVFtPAPSDSP activity, induced 23678047 2 5 2 -NR1I2 PXR DNA-binding; Nuclear receptor O75469 8856 3q13.33 human S114-p 30259801 MKKEMIMsDEAVEER molecular association, regulation transcription, inhibited DNA(DISRUPTS) 24184507 1 1 0 -IRS4 IRS4 Adaptor/scaffold O14654 8471 Xq22.3 human Y847-p 1877150802 GLDKEVSyNWDPKDA molecular association, regulation cell cycle regulation; carcinogenesis, induced; cell growth, induced EBNA1BP2(INDUCES) 35550247 1 1 0 -RETREG1 FAM134B Membrane protein, integral; Membrane protein, multi-pass Q9H6L5 54463 5p15.1 human S151-p 2509195 AQLWRSLsESWEVIN Reticulon molecular association, regulation autophagy, induced; apoptosis, induced FAM134B(INDUCES) 31930741; 37043189 2 6 0 -Arhgap12 ARHGAP12 GAP; GAP, Rac/Rho Q8C0D4 75415 18|18 A1 mouse T229-p 451930 TEQMRATtPPNQGRP SH3-WW_linker cell cycle regulation; cell motility, altered 18515860 0 37 43 -Htt Huntingtin Cytoskeletal P42859 15194 5 B2|5 17.92 cM mouse S13-p 10206805 KLMKAFEsLKSFQQQ protein degradation autophagy, induced; transcription, induced 31088970 19 3 0 -TGFBR3 TGFBR3 Membrane protein, integral Q03167 7049 1p22.1 human S831-p 23940713 SPPASENsSAAHSIG molecular association, regulation TRAF6(INDUCES) 22427868 1 0 0 -Nfatc2 NFAT1 DNA-binding; Transcription factor Q60591 18019 2 H3|2 88.91 cM mouse K897-ub 1852795100 LPTGVTVkQEQNLDQ protein degradation 21628454 1 0 0 in NFAT1 S215/219/223A triple mutant or when phosphorylation of those sites is inhibited by zoledronic acid -TTK TTK Cancer Testis Antigen (CTA); EC 2.7.12.1; KINASE; Kinase, protein; Protein kinase, Other; Protein kinase, dual-specificity (non-receptor) P33981 7272 6q14.1 human S7-p 4272730 _MESEDLsGRELTID intracellular localization cell cycle regulation 25265012; 36395767 2 6 0 autophosphorylation of this site is required for release TTK from kinetochore; causes decreased kinetochore localization of BubR1 and Mad2. -APBA2 APBA2 Adaptor/scaffold Q99767 321 15q13.1 human S238-p 7151800 AEIKMSLsMTSITSA molecular association, regulation APP(INDUCES) 19222704 1 1 0 -GAB2 GAB2 Adaptor/scaffold Q9UQC2 9846 11q14.1 human Y584-p 448385 SGDSEENyVPMQNPV molecular association, regulation PIK3R1(INDUCES) 11334882 1 0 0 -RAF1 RAF1 EC 2.7.11.1; KINASE; Kinase, protein; Oncoprotein; Protein kinase, Ser/Thr (non-receptor); Protein kinase, TKL P04049 5894 3p25.2 human S621-p 447746 PKINRSAsEPSLHRA molecular association, regulation; enzymatic activity, inhibited; protein conformation; phosphorylation; enzymatic activity, induced cell growth, altered 14-3-3 beta(INDUCES); 14-3-3 zeta(INDUCES) 10801873; 10998357; 18775988; 19595761; 19933846; 8816453 24 70 10 -PHGDH PHGDH Amino Acid Metabolism - glycine, serine and threonine; Cell development/differentiation; EC 1.1.1.95; Oxidoreductase O43175 26227 1p12 human K310-ub 1883421300 FVDMVKGkSLTGVVN protein degradation 35788583 1 0 0 -DOK1 DOK1 Adaptor/scaffold; Motility/polarity/chemotaxis Q99704 1796 2p13.1 human S446-p 454884 SGIKSHNsALYSQVQ cell motility, induced; cell growth, inhibited 15574499 1 2 24 -Cftr CFTR Channel, chloride; EC 3.6.3.49; Hydrolase; Membrane protein, integral; Membrane protein, multi-pass; Transporter; Transporter, ABC family P26361 12638 6 A2|6 8.1 cM mouse S670-p 3333405 TETLRRFsVDDSSAP CFTR_R protein conformation 19927121 1 3 0 in vitro -Camk2b CAMK2B EC 2.7.11.17; KINASE; Kinase, protein; Protein kinase, CAMK; Protein kinase, Ser/Thr (non-receptor) P28652 12323 11 A1|11 3.89 cM mouse S315-p 451707 MLATRNFsVGRQTTA cytoskeletal reorganization 28607044 4 17 4 interferes with its F-actin bundling and suppresses the excess spine formation and elongation in Purkinje cells -Trpv2 TRPV2 Channel, cation; Membrane protein, integral; Membrane protein, multi-pass Q9WUD2 29465 10q23 rat S37-p 8110156 QEPPPMEsPFQREDR cell growth, induced 26416880 1 3 3 neurite outgrowth -PLXNB1 PLXNB1 Membrane protein, integral; Motility/polarity/chemotaxis; Receptor, misc. O43157 5364 3p21.31 human Y1708-p 3413438 DSVGEPLyMLFRGIK Plexin_cytopl molecular association, regulation cell motility, altered GRB2(INDUCES); PLCG1(INDUCES); PLCG2(INDUCES) 19805522 1 1 1 -Eif3f eIF3-epsilon EC 3.4.19.12; Translation; Translation initiation Q9DCH4 66085 7|7 E3 mouse K357-ub 7388004 SQIALNEkLVNL___ MitMem_reg protein degradation 19073596 1 0 0 regulates skeletal muscle atrophy -Sting1 STING Apoptosis; Endoplasmic reticulum; Membrane protein, integral; Membrane protein, multi-pass; Mitochondrial Q3TBT3 72512 18 B2|18 mouse S365-p 31064700 QEPRLLIsGMDQPLP transcription, induced; transcription, inhibited; transcription, altered; signaling pathway regulation 30135079; 33785602; 34901991; 35613599 35 3 0 -FOXL2 FOXL2 DNA-binding; Transcription factor P58012 668 3q22.3 human S33-p 21697903 EPEGPPPsPGKGGGG sumoylation; protein degradation; protein stabilization; molecular association, regulation; ubiquitination; intracellular localization carcinogenesis, induced; apoptosis, inhibited; transcription, inhibited UBC9(DISRUPTS); MDM2(INDUCES) 22022399; 24390485 3 9 1 sumoylation and protein stability is induced in FOXL2 wt cells; in patients carrying FOXL2 C134 mutantion -LRP2 LRP2 Membrane protein, integral; Motility/polarity/chemotaxis; Receptor, misc. P98164 4036 2q31.1 human S4627-p 767903 PAKPKPPsRRDPTPT receptor internalization, altered; receptor recycling, altered 17555532 1 1 0 -Myo3a MYO3A Actin-binding; EC 2.7.11.1; KINASE; Kinase, protein; Motor; Protein kinase, STE; Protein kinase, Ser/Thr (non-receptor) Q8K3H5 667663 2|2 A3 mouse T184-p 29674700 STRHRLNtSVGTPFW Pkinase enzymatic activity, induced 21895655 3 3 0 -NOX5 NOX5 iso4 EC 1.6.3.-; Membrane protein, integral; Membrane protein, multi-pass; Oxidoreductase Q96PH1-4 79400 15q23 human S498-p 472626 RSVTMRKsQRSSKGS FAD_binding_8 activity, induced; enzymatic activity, induced 17164239; 21297032; 24505490; 24992705 5 0 0 -AKT1 Akt1 EC 2.7.11.1; KINASE; Kinase, protein; Oncoprotein; Protein kinase, AGC; Protein kinase, Ser/Thr (non-receptor) P31749 207 14q32.33 human K214-ub 1877462100 HPFLTALkYSFQTHD Pkinase protein degradation; molecular association, regulation autophagy, induced GRP78(INDUCES) 32164484 1 0 0 HSPA5 arginylation, modulated by ATE1 -Calm1 Calmodulin Calcium-binding; Protein phosphatase, regulatory subunit P0DP29 24242 6q32 rat S102-p 448706 KDGNGYIsAAELRHV EF-hand_7 molecular association, regulation; activity, inhibited KCNQ4(INDUCES) 24627475; 8206911 7 27 40 T80 site is key to binding. CAM phosphorylation regulates channel trafficking and stabilizes activity-thereby regulating neuronal excitability.; Calmodulin phosphorylated by CKII in vitro showed reduced activation of erythrocyte plasma membrane Ca2+ pump. -Scnn1g ENaC-gamma Channel, sodium; Membrane protein, integral; Membrane protein, multi-pass; Transporter, ion channel P37091 24768 1q36 rat K13-ub 486254 KIKAKIKkNLPVRGP receptor recycling, inhibited; protein degradation; intracellular localization 9351815 1 0 0 -NR4A1 Nur77 Apoptosis; DNA-binding; Nuclear receptor P22736 3164 12q13.13 human T143-p 15068600 CSAPSPStPSFQPPQ sumoylation; protein stabilization; intracellular localization autophagy, induced 22234305; 32210435 3 0 0 -PRDX1 PRDX1 EC 1.11.1.15; Nuclear receptor co-regulator; Oxidoreductase Q06830 5052 1p34.1 human T90-p 455554 CHLAWVNtPKKQGGL AhpC-TSA molecular association, regulation; enzymatic activity, inhibited; protein conformation PRDX1(INDUCES) 11986303; 16376335; 23386615 4 2 0 -BNIP3L BNIP3L Apoptosis; Endoplasmic reticulum; Membrane protein, integral; Mitochondrial; Nuclear envelope O60238 665 8p21.2 human S34-p 65958200 PPPAGLNsSWVELPM BNIP3 molecular association, regulation autophagy, induced LC3B(INDUCES) 28442745 1 0 0 -TCOF1 treacle Nucleolus; RNA-binding; Transcription, coactivator/corepressor Q13428 6949 5q32-q33.1 human T210-p 35530406 TSSSSDEtDVEGKPS molecular association, regulation NBS1(INDUCES) 25064736 1 1 0 downregulation of rRNA transcription due to the interaction with NBS1 in response to DNA damage. -SORBS2 ArgBP2 iso2 Adaptor/scaffold; Motility/polarity/chemotaxis O94875-2 8470 4q35.1 human Y573-p 11057708 NTKGAEDyPDPPIPH protein conformation 24475245 1 0 2 reduced self-interaction -GJA1 GJA1 Channel, misc.; Membrane protein, integral; Membrane protein, multi-pass; Motility/polarity/chemotaxis P17302 2697 6q22.31 human S365-p 459207 IVDQRPSsRASSRAS protein conformation 23828237 15 15 2 -MCM2 MCM2 DNA-binding; EC 3.6.4.12 P49736 4171 3q21.3 human S5-p 2201405 ___MAESsESFTMAS intracellular localization 19647517 2 12 0 promotes Mcm2 loading onto chromatin -DYRK3 DYRK3 EC 2.7.12.1; KINASE; Kinase, protein; Protein kinase, CMGC; Protein kinase, dual-specificity (non-receptor) O43781 8444 1q32.1 human S350-p 23101265 LKHHGRSsTKVIDFG Pkinase protein stabilization; enzymatic activity, induced 29634919 1 1 1 -Pde4b PDE4B EC 3.1.4.53; Nucleotide Metabolism - purine; Phosphodiesterase Q8VBU5 18578 4 C6|4 46.99 cM mouse S304-p 4765135 KKLMHSSsLNNTSIS enzymatic activity, induced 26952277 1 9 13 -DUSP12 DUSP12 EC 3.1.3.16; EC 3.1.3.48; Motility/polarity/chemotaxis; PHOSPHATASE; Protein phosphatase, dual-specificity Q9UNI6 11266 1q23.3 human S335-p 3851464 KILPVLGsQTGKI__ intracellular localization cell cycle regulation 21521943 1 2 5 -Th TH Amino Acid Metabolism - tyrosine; EC 1.14.16.2; Endoplasmic reticulum; Mitochondrial; Oxidoreductase; Vesicle P04177 25085 1q41 rat S19-p 448542 KGFRRAVsEQDAKQA TOH_N protein stabilization; molecular association, regulation; protein conformation; enzymatic activity, induced 14-3-3 theta(INDUCES) 10820208; 11502746; 14675149; 15228599; 15639226; 9751201 46 9 4 -XRCC5 Ku80 DNA-binding; EC 3.6.1.-; EC 3.6.4.-; Helicase; Nuclear receptor co-regulator; Nucleolus; RNA-binding P13010 7520 2q35 human K202-ub 15391490 KGITEQQkEGLEIVK Ku_N molecular association, regulation DNA repair, induced DNA(DISRUPTS) 27895153 1 6 1 -EGLN1 EGLN1 EC 1.14.11.29; Oxidoreductase Q9GZT9 54583 1q42.2 human K297-m1 1883819300 YKINGRTkAMVACYP enzymatic activity, inhibited cell growth, induced; signaling pathway regulation 35452683 1 1 0 K297 methylation attenuates its effect on HIF1a-mediated hypoxia signaling; the prolyl hydroxylase activity of EGLN1 is inhibited -FOXM1 FOXM1 iso2 DNA-binding; Transcription factor Q08050-2 2305 12p13.33 human K218-sm 31898504 HLEQRQVkVEEPSRP protein degradation transcription, inhibited 25533473 2 0 0 -MYC Myc DNA-binding; Nucleolus; Oncoprotein; Transcription factor P01106 4609 8q24.21 human S86-p 449991 SRRSGLCsPSYVAVT Myc_N protein stabilization; phosphorylation apoptosis, altered; carcinogenesis, inhibited; cell growth, induced; apoptosis, induced; apoptosis, inhibited; transcription, induced; transcription, inhibited 10551811; 11243879; 24030976; 25109329; 33461590 7 12 0 inhibits phosphorylation at T58 -ATG13 ATG13 Autophagy; Vesicle O75143 9776 11p11.2 human S224-p 53377101 DRPYPSSsPMHPCNY cell cycle regulation; autophagy, induced; cell growth, induced 32516310 2 2 0 -CACNA1C CACNA1C Channel, calcium; Membrane protein, integral; Membrane protein, multi-pass Q13936 775 12p13.33 human Y1920-p 1043300 ETSQDETyEVKMNHD activity, induced 17942635 2 0 1 Ca(2+) currents -Foxp3 FOXP3 C2H2-type zinc finger protein; Cell cycle regulation; DNA-binding; Transcription factor Q99JB6 20371 X A1.1|X 3.41 cM mouse K31-ac 25614402 PSWKTAPkGSELLGT protein stabilization; ubiquitination cell differentiation, induced 22312127 2 1 0 inhibits ubiquitination -MAZ MAZ C2H2-type zinc finger protein; RNA-binding; Transcription factor P56270 4150 16p11.2 human T72-p 451250 AAPAPPPtPQAPAAE activity, induced transcription, induced 11809795 1 0 0 -FKBP1A FKBP12 EC 5.2.1.8; Isomerase P62942 2280 20p13 human K35-ub 3931455 TGMLEDGkKFDSSRD FKBP_C protein conformation 31375563 1 3 19 Partially unfolded but not aggregated drives FKBP12 ubiquitylation at the proteasome -Notch1 Notch 1 Membrane protein, integral; Motility/polarity/chemotaxis; Oncoprotein; Receptor, misc.; Transcription factor Q01705 18128 2 A3|2 18.91 cM mouse R2317-m2 56852201 PSQYNPLrPGVTPGT activity, induced; protein degradation; ubiquitination transcription, induced 25805888 1 1 0 -Syp SYP Membrane protein, integral; Membrane protein, multi-pass; Vesicle P07825 24804 Xq12 rat Y273-p 10769104 QGGYQPDyGQPASGG molecular association, regulation LYN(INDUCES); Src(INDUCES) 23103755 1 1 0 -Tlr3 TLR3 Membrane protein, integral; Receptor, cytokine Q99MB1 142980 8|8 B1.1 mouse Y760-p 450187 EQFEYTAyIIHAHKD TIR cell growth, induced; transcription, induced 24526685 4 0 0 -Rlim RNF12 EC 6.3.2.-; Ligase; Transcription, coactivator/corepressor; UBIQUITIN LIGASE; Ubiquitin conjugating system; Ubiquitin ligase Q9WTV7 19820 X 46.42 cM|X D mouse S214-p 18014966 QRRARSRsPEHRRTR intracellular localization cell motility, induced; apoptosis, inhibited 23904271 1 0 0 phosphorylated S214 (human) or S215 (murine) RNF12 is localized in nucleus; shuttling of RNF12 is important for promoting cell motility and alveolar cell survival -CASP9 CASP9 Apoptosis; EC 3.4.22.62; Protease P55211 842 1p36.21 human S196-p 448454 KLRRRFSsLHFMVEV Peptidase_C14 activity, inhibited apoptosis, induced; apoptosis, inhibited 34705620; 9812896 4 1 0 -Glp1r GLP1R GPCR, family 2; Membrane protein, integral; Membrane protein, multi-pass; Receptor, GPCR P32301 25051 20p12 rat S444-p 451382 KCPTSSVsSGATVGS receptor desensitization, altered 8702711 1 0 0 -CALR Calreticulin ACETYLTRANSFERASE; Acetyltransferase; Calcium-binding; Motility/polarity/chemotaxis; Nuclear receptor co-regulator; Secreted; Secreted, signal peptide P27797 811 19p13.13 human K48-ac 4219810 KHKSDFGkFVLSSGK Calreticulin protein conformation 18795239 1 4 1 -TTK TTK Cancer Testis Antigen (CTA); EC 2.7.12.1; KINASE; Kinase, protein; Protein kinase, Other; Protein kinase, dual-specificity (non-receptor) P33981 7272 6q14.1 human T45-p 1880463702 LNKISADtTDNSGTV intracellular localization 36395767 1 0 0 -Chpt1 CHPT1 EC 2.7.8.2; Lipid Metabolism - ether lipid; Lipid Metabolism - glycerophospholipid; Membrane protein, integral; Membrane protein, multi-pass; Transferase Q8C025 212862 10|10 C1 mouse K254-ub 12718513 ILHGGVGkNGSTIAG protein degradation; enzymatic activity, inhibited 20018880 1 0 0 -LALBA LALBA Apoptosis; Secreted; Secreted, signal peptide; Transferase P00711 281894 cow T48-p 1875112303 SLPEWVCtTFHTSGY Lys molecular association, regulation; protein conformation IGE(DISRUPTS); IgG(DISRUPTS) 34655828 0 1 0 -OPRM1 MOR-1 GPCR, family 1; Membrane protein, integral; Membrane protein, multi-pass; Receptor, GPCR P35372 4988 6q25.2 human T372-p 447785 STRIRQNtRDHPSTA receptor internalization, altered 18463167 19 5 0 -NR5A1 STF-1 Nuclear receptor; Transcription, coactivator/corepressor Q13285 2516 9q33.3 human K34-ac 458972 LLTCESCkGFFKRTV zf-C4 protein stabilization; intracellular localization transcription, induced 11479297 1 0 0 localization to the cytoplasm -CYCS CYCS Apoptosis; Mitochondrial; Oxidoreductase; PHOSPHATASE; Protein phosphatase, Ser/Thr (non-receptor) P99999 54205 7p15.3 human K8-ac 1968624 MGDVEKGkKIFIMKC Cytochrom_C molecular association, regulation; protein conformation 34455704 1 1 0 loss of positive potential at the surface areas around the mutated residue, thermal stability of Cc species is slightly changed, local structural changes, and increased binding afinity for the Cc1-Cc complex for the K8 mutants -RUNX1 AML1 DNA-binding; Oncoprotein; Transcription factor Q01196 861 21q22.12 human K125-ub 15384401 RNATAAMkNQVARFN Runt protein degradation; intracellular localization carcinogenesis, inhibited; cell growth, inhibited; transcription, inhibited 28536267 1 4 2 -Trpm7 ChaK1 Channel, cation; EC 2.7.11.1; KINASE; Kinase, protein; Membrane protein, integral; Membrane protein, multi-pass; Protein kinase, Ser/Thr (non-receptor); Protein kinase, atypical Q923J1 58800 2|2 F1 mouse S1360-p 31909861 ALFPSAVsPPELRQR protein stabilization; intracellular localization 29866880 1 4 0 regulates proteosome-mediated turnover -CDKN1A p21Cip1 Cell cycle regulation; Inhibitor P38936 1026 6p21.2 human S130-p 455618 SGEQAEGsPGGPGDS protein degradation; molecular association, regulation; protein stabilization; ubiquitination; intracellular localization; phosphorylation cell cycle regulation CDK4(DISRUPTS); CDK2(DISRUPTS); CCND1(DISRUPTS) 12058028; 15964852; 16508017; 19364816; 22227330; 23737759; 27384476 11 11 7 -NHE-3 NHE3 Membrane protein, integral; Membrane protein, multi-pass; Transporter; Transporter, SLC family P26432 100009430 rabbit S526-p 31839902 MRQSAQKsRDRILNV activity, induced; molecular association, regulation; intracellular localization; phosphorylation Ezrin(INDUCES) 24398676 1 0 0 stimulates Akt to phosphorylate S515 -CENPA CENPA DNA-binding P49450 1058 2p23.3 human S17-p 485047 PEAPRRRsPSPTPTP Histone protein conformation cell cycle regulation 23818633 2 30 7 chromosome segregation -PIAS1 PIAS1 EC 6.3.2.-; Nuclear receptor co-regulator; SUMO LIGASE; SUMO conjugating system; SUMO ligase; Transcription, coactivator/corepressor O75925 8554 15q23 human K137-sm 55435676 HPVHPDIkLQKLPFY PINIT intracellular localization 32047143 1 3 0 -TP53 p53 Activator; DNA-binding; Motility/polarity/chemotaxis; Nuclear receptor co-regulator; Transcription factor; Tumor suppressor P13481 green monkey S15-p 447490 PSIEPPLsQETFSDL P53_TAD molecular association, regulation BLM(INDUCES); ATRX(INDUCES); MRE11A(INDUCES); RAD51(INDUCES) 15806145 480 12 0 -Cacnb2 CACNB2 Channel, calcium Q8VGC3 116600 17q12.3 rat S529-p 1868239900 KKSQHRSsSATHQNH activity, induced 10567342 4 0 0 -SMAD2 SMAD2 DNA-binding; Transcription factor Q15796 4087 18q21.1 human S465-p 447494 SPSVRCSsMS_____ activity, induced; molecular association, regulation; intracellular localization carcinogenesis, induced; cell differentiation, induced; transcription, induced; transcription, altered TGFBR1(DISRUPTS); SMAD4(INDUCES) 11043574; 21996745; 31995604; 33963314; 35075279; 36461015; 8980228; 9346908; 9346966 57 1 5 S464 not likely phosphorylated but is required for efficient phosphorylation of COOH terminus. -Gabrg2 GABRG2 Channel, chloride; Channel, ligand-gated; Membrane protein, integral; Membrane protein, multi-pass; Transporter; Transporter, ion channel P22723 14406 11 A5|11 24.8 cM mouse K363-ub 11956712 HYFVSNRkPSKDKDK Neur_chan_memb protein degradation; receptor internalization, altered 19815531 1 0 0 regulation of the late endosomal/lysosomal trafficking of GABA receptors, regulation of synaptic transmission -Zdhhc3 ZDHHC3 EC 2.3.1.225; Membrane protein, integral; Membrane protein, multi-pass; Transferase Q8R173 69035 9|9 F4 mouse Y295-p 464577 DQGKADPyQYVV___ enzymatic activity, inhibited cytoskeletal reorganization 27247265 1 0 31 neurite outgrowth; palmitoylation -RYR2 RYR2 Channel, ligand-gated; Membrane protein, integral; Membrane protein, multi-pass; Transporter; Transporter, ion channel P30957 rabbit S2815-p 458801 ISQTSQVsVDAAHGY activity, inhibited 21555709 63 8 5 inhibits SERCA2 activity -NCAPH NCAPH Cell cycle regulation Q15003 23397 2q11.2 human S570-p 470129 PGLQAADsDDEDLDD Cnd2 phosphorylation chromatin organization, altered 17066080 1 1 3 The phosphorylation of this site was half as strong in mitosis as compared to interphase NCAPH. This CK2 mediated site was dephosphorylated efficiently only on mitotic chromosomes.Dephosphorylation also occured using purified human condensin with Xenopus egg extract. Dephosphorylation of CK2 specific sites greatly increases supercoiling activity of NCAPH. Chromosome length in CK2 supplemented extracts was two-fold longer than in control extracts. -Incenp INCENP Cell cycle regulation; EC 2.7.11.1 Q9WU62 16319 19 A|19 6.1 cM mouse T388-p 458333 ATKIAIStPTSKPAA molecular association, regulation cell cycle regulation PLK1(INDUCES) 16378098 1 0 1 phosphorylation plays important role in recruitment of Plk1 to kinetochores and progression of cell cycle -KCNA2 Kv1.2 Channel, potassium; Membrane protein, integral; Membrane protein, multi-pass P16389 3737 1p13.3 human Y415-p 455552 VIVSNFNyFYHRETE Ion_trans molecular association, regulation Cortactin(DISRUPTS) 12151401 1 0 1 -CRTC1 TORC1 iso2 Transcription factor Q6UUV9-2 23373 19p13.11 human S346-p 15412157 QQASPTLsPLSPITQ protein degradation transcription, inhibited 29408765 1 0 3 -Grk2 GRK2 EC 2.7.11.15; KINASE; Kinase, protein; Protein kinase, AGC; Protein kinase, Ser/Thr (non-receptor) P26817 25238 1q43 rat S29-p 447724 ATPAARAsKKILLPE intracellular localization; enzymatic activity, induced 20194499 2 0 0 -Srrm2 SRm300 RNA splicing; RNA-binding; Spliceosome Q8BTI8 75956 17|17 A3.3 mouse S1068-p 453278 GSLSRSSsPVTELTA protein degradation; molecular association, regulation; intracellular localization CCTA(DISRUPTS) 30283027 1 82 18 changes the subcellular localization of SRm300 from the nucleus to the cytoplasm -Cbx1 CBX1 Transcription factor P83917 12412 11 D|11 60.11 cM mouse T51-p 2753801 GFSDEDNtWEPEENL Chromo molecular association, regulation; intracellular localization DNA(DISRUPTS) 19657222 2 0 0 -TERF1 TRF1 DNA-binding P54274 7013 8q21.11 human S114-p 63083903 AIIHGLSsLTACQLR TRF protein stabilization; molecular association, regulation TINF2(INDUCES); FBXO4(DISRUPTS) 28216227 1 1 0 Increased Interaction with Tin2, Increased cell survival and telomere protection -ULK1 ULK1 Autophagy; EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, Other; Protein kinase, Ser/Thr (non-receptor) O75385 8408 12q24.33 human T1046-p 10428800 RRLSALLtGICA___ DUF3543 protein degradation; molecular association, regulation autophagy, inhibited KLHL20(INDUCES) 26687681 2 2 0 -CENATAC CENATAC Q86UT8 338657 11q23.3 human K31-ac 27584361 RKHQRQLkEALERLL CCDC84 molecular association, regulation 31722219 1 2 0 acetylated CCDC84 promotes HsSAS-6 ubiquitination by enhancing the binding af?nity of HsSAS-6 for Cdh1; regulates centrosome number -NKX3-1 NKX3-1 DNA-binding; Transcription factor; Tumor suppressor Q99801 4824 8p21.2 human T134-p 28750701 SRAAFSHtQVIELER Homeodomain protein degradation; ubiquitination 23890999 1 0 0 -Klf4 KLF4 C2H2-type zinc finger protein; DNA-binding; Transcription factor Q60793 16600 4 B3|4 29.76 cM mouse S132-p 24976100 ASASSSSsPASSGPA protein degradation; molecular association, regulation; ubiquitination; intracellular localization cell differentiation, induced; transcription, inhibited Exportin-1(INDUCES); ERK2(INDUCES); FBW1B(INDUCES) 22307056; 29526737; 31221664 3 0 0 nuclear export; dephosphorylation causes nuclear localization and hence stability; Nanog and Klf4 transcription inhibited -Syngap1 SynGAP iso3 GAP; GAP, Ras Q9QUH6-3 192117 20p12 rat S783-p 18710212 LSVNKSVsMLDLQGD DUF3498 molecular association, regulation; intracellular localization HRas(INDUCES) 21382555 1 2 1 -MAPK11 P38B EC 2.7.11.24; KINASE; Kinase, protein; Protein kinase, CMGC; Protein kinase, Ser/Thr (non-receptor) Q15759 5600 22q13.33 human T241-p 54390600 RIMEVVGtPSPEVLA Pkinase cell differentiation, induced 26976637 1 1 0 -OXSR1 OSR1 EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, STE; Protein kinase, Ser/Thr (non-receptor) O95747 9943 3p22.2 human S325-p 456504 VRRVPGSsGRLHKTE activity, induced; enzymatic activity, induced 18270262; 29581290 14 12 0 2.5-fold increase in Kir2.1 channel activity when cotransfected compared to Kir2.1 alone -NDC80 HEC1 Cell cycle regulation O14777 10403 18p11.32 human S76-p 459765 SQLGIFSsSEKIKDP Ndc80_HEC cytoskeletal reorganization 35878017 1 2 0 -FOXA1 FOXA1 DNA-binding; Transcription factor P55317 3169 14q21.1 human K270-me 1877309700 QKRFKCEkQPGAGGG protein degradation chromatin organization, altered DNA(DISRUPTS) 32868907 1 1 0 AR chromatin recruitment is impaired -Dcx Doublecortin Cytoskeletal; Motility/polarity/chemotaxis O88809 13193 X|X F2 mouse S332-p 451363 STPKSKQsPISTPTS intracellular localization cell motility, altered; cell growth, altered TUBB(DISRUPTS) 20715151 7 4 14 -NANOG NANOG Cell development/differentiation; DNA-binding; Transcription factor Q9H9S0 79923 12p13.31 human S68-p 1394461701 LIQDSPDsSTSPKGK protein stabilization; molecular association, regulation cell growth, induced; transcription, induced SPOP(DISRUPTS) 30595535 1 0 0 -EZH2 EZH2 EC 2.1.1.43; METHYLTRANSFERASE; Methyltransferase; Methyltransferase, protein lysine Q15910 2146 7q36.1 human K421-m1 1883327700 CQTPIKMkPNIEPPE protein degradation cell growth, inhibited; cell motility, inhibited 36127410 1 0 0 promotes M2 macrophage polarization -KCNJ1 ROMK Channel, potassium; Membrane protein, integral; Membrane protein, multi-pass P48048 3758 11q24.3 human S219-p 2461201 RVANLRKsLLIGSHI IRK_C activity, induced; protein conformation; activity, inhibited 18547545; 18571730; 18620882 5 0 0 -MAPK3 ERK1 EC 2.7.11.24; KINASE; Kinase, protein; Protein kinase, CMGC; Protein kinase, Ser/Thr (non-receptor) P27361 5595 16p11.2 human K72-ac 1873356102 KTRVAIKkISPFEHQ Pkinase enzymatic activity, inhibited; protein conformation; phosphorylation transcription, inhibited 29259132 1 1 0 Inhibits phosphorylation -VAV1 VAV1 GEF; GEF, Rac/Rho; Motility/polarity/chemotaxis; Oncoprotein P15498 7409 19p13.3 human Y160-p 447865 VEEDEDLyDCVENEE molecular association, regulation; activity, inhibited cell motility, induced; cytoskeletal reorganization; cell adhesion, altered ITGB3(INDUCES); PLCG1(INDUCES); Lck(INDUCES); PIK3R1(INDUCES) 15699036; 17050525; 29058761 9 2 0 regulates Cdc42 activation. ; neutrophil crawling behavior -ANXA1 ANXA1 Calcium-binding; Lipid-binding P04083 301 9q21.13 human S27-p 447972 EYVQTVKsSKGGPGS molecular association, regulation; intracellular localization carcinogenesis, induced; exocytosis, altered; exocytosis, induced; cytoskeletal reorganization FPR2(INDUCES) 11482905; 19625660; 27634935; 32133417; 34944403 8 0 0 -TRAF4 TRAF4 Adaptor/scaffold; DNA-binding; UBIQUITIN LIGASE; Ubiquitin conjugating system; Ubiquitin ligase Q9BUZ4 9618 17q11.2 human S426-p 3211032 KPGTWRGsLDESSLG protein stabilization signaling pathway regulation 22547678 1 30 9 negative regulator of an innate immune signaling pathway -GRK2 GRK2 EC 2.7.11.15; KINASE; Kinase, protein; Protein kinase, AGC; Protein kinase, Ser/Thr (non-receptor) P21146 282682 cow S670-p 447725 KMKNKPRsPVVELSK activity, inhibited 10574913 5 40 18 -IKBKB IKKB EC 2.7.11.10; KINASE; Kinase, protein; Protein kinase, Other; Protein kinase, Ser/Thr (non-receptor) O14920 3551 8p11.21 human S740-p 5014909 SFTALDWsWLQTEEE IKKbetaNEMObind molecular association, regulation IKKG(DISRUPTS) 18957422 1 1 0 -HDAC2 HDAC2 DEACETYLASE; Deacetylase; EC 3.5.1.98; Nuclear receptor co-regulator; Transcription, coactivator/corepressor Q92769 3066 6q21 human S422-p 467979 IACDEEFsDSEDEGE molecular association, regulation; acetylation; enzymatic activity, inhibited p53(INDUCES); HDAC1(INDUCES) 20388487 3 77 49 -ATF2 ATF-2 ACETYLTRANSFERASE; C2H2-type zinc finger protein; EC 2.3.1.48; Transcription factor P15336 1386 2q31.1 human S121-p 6406001 LATPIIRsKIEEPSV intracellular localization transcription, induced 19176525 1 0 0 plays a role in the regulation of both TPA- and c-Jun-dependent transcription -SRC Src EC 2.7.10.2; KINASE; Kinase, protein; Oncoprotein; Protein kinase, TK; Protein kinase, tyrosine (non-receptor) P12931 6714 20q11.23 human Y530-p 448235 FTSTEPQyQPGENL_ protein degradation; molecular association, regulation; enzymatic activity, inhibited; protein processing; enzymatic activity, induced; phosphorylation; activity, induced; intracellular localization; protein conformation carcinogenesis, induced; carcinogenesis, inhibited; cell growth, inhibited; cell motility, induced; cell motility, inhibited; signaling pathway regulation; cell adhesion, inhibited; cell growth, induced Src(INDUCES); TM4SF5(INDUCES); FBXL7(DISRUPTS) 11035005; 12052863; 14506284; 16790421; 18454177; 20615878; 21399647; 21442427; 21873224; 23453597; 23471971; 23532252; 24300854; 24931162; 25386896; 32839549; 33761359; 34335982; 34385357; 34606417; 35293964; 35697802; 36765146; 37428018; 9655255 153 24 968 inhibits phosphorylation of FAK, p130Cas, and paxillin -Nlgn1 NLGN1 Membrane protein, integral Q99K10 192167 3|3 A3 mouse Y782-p 1008111 RTACPPDyTLAMRRS molecular association, regulation; intracellular localization neural plasticity; cell differentiation, induced gephyrin(DISRUPTS); PSD-95(DISRUPTS) 30266896; 32324534 3 1 0 regulates AMPAR recruitment; long-term potentiation (LTP), dendritic spine formation -APPL1 APPL Adaptor/scaffold; Nuclear receptor co-regulator Q9UKG1 26060 3p14.3 human S410-p 25802100 SFQQRHEsLRPAAGQ molecular association, regulation; receptor recycling, induced; receptor recycling, altered endocytosis, inhibited OCRL(DISRUPTS) 17765681; 29212031 2 3 0 -SNRNP70 snRNP 70 RNA splicing; RNA-binding; Spliceosome P08621 6625 19q13.33 human S140-p 2103618 HMVYSKRsGKPRGYA RRM_1 molecular association, regulation; intracellular localization apoptosis, induced; cell growth, altered HLA-DQB1(INDUCES) 12548559; 18202700 2 0 1 present in apoptotic bodies; Phosphorylated peptide S140-P induced CD4+ Tcell proliferation and IL-2 secretion in MLR/lpr mice. -NOTCH1 Notch 1 Membrane protein, integral; Motility/polarity/chemotaxis; Oncoprotein; Receptor, misc.; Transcription factor P46531 4851 9q34.3 human T2511-p 483083 VPEHPFLtPSPESPD protein degradation; molecular association, regulation; ubiquitination; activity, inhibited carcinogenesis, altered; carcinogenesis, inhibited; cell growth, inhibited; cell motility, altered; cell motility, inhibited; transcription, inhibited; signaling pathway regulation FBXW7(INDUCES) 25344755; 27335110; 27806347; 31605148 5 1 0 triggers degradation by FBXW7; Notch1 signaling pathway regulation -Prkci PKCI Cell adhesion; Cell development/differentiation; EC 2.7.11.13; KINASE; Kinase, protein; Motility/polarity/chemotaxis; Oncoprotein; Protein kinase, AGC; Protein kinase, Ser/Thr (non-receptor); Tumor suppressor F1M7Y5 84006 2q24 rat Y334-p 450074 RLFFVIEyVNGGDLM Pkinase activity, induced 11713277 1 0 0 -Map3k12 DLK EC 2.7.11.25; KINASE; Kinase, protein; Protein kinase, Ser/Thr (non-receptor); Protein kinase, TKL Q60700 26404 15|15 F3 mouse S584-p 40416401 KTRHRKAsAKGSCGD enzymatic activity, inhibited cell growth, induced 25802931 1 1 0 S584A T659A mutants have inhibited growth and increased kinase activity -PELI1 PELI1 Adaptor/scaffold; EC 6.3.2.-; EC 6.3.2.19; Ligase; UBIQUITIN LIGASE; Ubiquitin conjugating system; Ubiquitin ligase Q96FA3 57162 2p14 human S78-p 7388013 NKDQHSIsYTLSRAQ Pellino ubiquitination; enzymatic activity, induced 19264966 2 0 0 -IRF3 IRF3 DNA-binding; Transcription factor Q14653 3661 19q13.33 human T75-p 55458201 RDKPDLPtWKRNFRS IRF molecular association, regulation; protein conformation transcription, inhibited DNA(DISRUPTS) 27125670 1 0 0 -Camkk2 CAMKK2 Autophagy; EC 2.7.11.17; KINASE; Kinase, protein; Protein kinase, Other; Protein kinase, Ser/Thr (non-receptor) O88831 83506 12q16 rat T144-p 15425433 PRMPRRPtVESHHVS activity, induced; enzymatic activity, inhibited; enzymatic activity, induced signaling pathway regulation 28974582; 30660766; 32085894 3 3 5 autonomous activity of CAMKK2 reversible to the phosphorylation by PKA -DNMT1 DNMT1 Amino Acid Metabolism - cysteine and methionine; Cell development/differentiation; EC 2.1.1.37; METHYLTRANSFERASE; Methyltransferase; Methyltransferase, DNA; Transcription regulation P26358 1786 19p13.2 human K148-sm 12726304 SKSDGEAkPEPSPSP enzymatic activity, induced DNA(INDUCES) 19450230 1 0 0 -DTNB DTNB Calcium-binding; Motility/polarity/chemotaxis O60941 1838 2p23.3 human T11-p 27100600 ESGNKRKtMAEKRQL molecular association, regulation KIF1A(INDUCES) 22978324 1 1 0 -Ncoa3 SRC-3 ACETYLTRANSFERASE; Acetyltransferase; EC 2.3.1.48; Motility/polarity/chemotaxis; Nuclear receptor co-regulator; Transcription, coactivator/corepressor O09000 17979 2|2 H3 mouse S847-p 453084 PPYNRAVsLDSPVSV methylation; phosphorylation carcinogenesis, inhibited; cell growth, inhibited; cell differentiation, induced; transcription, inhibited; signaling pathway regulation 17043108; 20534466 11 48 5 inhibits insulin/IGF1 signaling; S847 phosphorylation antagonizes Src-3 methylation -Cebpb C/EBP-beta DNA-binding; Motility/polarity/chemotaxis; Transcription factor P21272 24253 3q42 rat T189-p 447878 SSSSPPGtPSPADAK transcription, altered; cell growth, altered DNA(INDUCES) 15314150; 16055922 33 11 14 -HCLS1 HS1 Adaptor/scaffold; Motility/polarity/chemotaxis P14317 3059 3q13.33 human Y378-p 451635 EPEPENDyEDVEEMD activity, induced; molecular association, regulation; intracellular localization apoptosis, altered; cell motility, induced; cell motility, altered; cytoskeletal reorganization; transcription, altered ARPC2(INDUCES); VAV1(INDUCES) 16782030; 18587398; 22679023; 25723543; 9104825 8 2 37 -PAK1 PAK1 EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, STE; Protein kinase, Ser/Thr (non-receptor) Q13153 5058 11q13.5-q14.1 human K29-ub 56714906 TMIGAGSkDAGTLNH protein degradation 27302166 1 0 0 -NPR1 ANPA EC 4.6.1.2; Guanylyl cyclase; KINASE; Kinase, protein; Lyase; Membrane protein, integral; Nucleotide Metabolism - purine; Protein kinase, RGC; Protein kinase, dual-specificity (receptor); Receptor, misc. P16066 4881 1q21.3 human S542-p 448229 GRGSNYGsLLTTEGQ activity, induced; enzymatic activity, induced 28416574; 9528788 3 2 3 -Map1lc3a LC3A Autophagy; Microtubule-binding; Ubiquitin-like modifier; Vesicle Q91VR7 66734 2|2 H1 mouse S12-p 15116600 RPFKQRRsFADRCKE intracellular localization autophagy, altered 20713600 2 1 0 -BACH2 BACH2 DNA-binding; Transcription factor Q9BYV9 60468 6q15 human K202-sm 2798314 AAIPVAEkEEALLPE intracellular localization 18201693 2 0 0 mobility of nuclear domains -MAP3K11 MLK3 EC 2.7.11.25; KINASE; Kinase, protein; Protein kinase, Ser/Thr (non-receptor); Protein kinase, TKL Q16584 4296 11q13.1 human T477-p 36324901 HVRRRRGtFKRSKLR protein degradation; molecular association, regulation; ubiquitination; intracellular localization carcinogenesis, inhibited; apoptosis, inhibited 14-3-3 zeta(INDUCES) 25204656; 33875576 2 0 0 -RUBCNL RUBCNL Q9H714 80183 13q14.13 human K573-ac 1875445902 EDLVRIKkGLLAPLL zf-RING_9 molecular association, regulation autophagy, induced VPS39(INDUCES); VPS41(INDUCES); STX17(INDUCES) 30704899 1 1 0 required for autophagosome maturation and cellular lipid metabolism -HSF1 HSF1 DNA-binding; Transcription factor Q00613 3297 8q24.3 human S368-p 469242 PPSPPPTsTPEKCLS Vert_HS_TF transcription, inhibited 25963659 2 5 7 under non-stressed conditions, upon heat shock S to A mutant showed 60% higher luciferase activity -SMAD2 SMAD2 DNA-binding; Transcription factor Q15796 4087 18q21.1 human K54-ac 1876755703 SLVKKLKkTGRLDEL MH1 intracellular localization; phosphorylation transcription, induced 32535965 1 0 0 -LILRB2 LILRB2 Membrane protein, integral; Receptor, misc. Q8N423 10288 19q13.42 human Y561-p 2091907 EAPQDVTyAQLHSLT molecular association, regulation CSK(INDUCES); SHP-1(INDUCES) 11907092; 15474475 2 0 1 Mutation of Y533 prevented binding in vivo. -Atg3 ATG3 Autophagy; EC 6.3.2.-; Ubiquitin conjugating system Q9CPX6 67841 16|16 B5 mouse Y203-p 62940500 QTRTYDLyITYDKYY Autophagy_act_C protein degradation; molecular association, regulation; ubiquitination cell growth, induced BAG3(INDUCES) 28103122 1 1 0 mitotic catastrophe -Sqstm1 SQSTM1 Autophagy; Nuclear receptor co-regulator; Ubiquitin conjugating system Q64337 18412 11|11 B1.3 mouse S351-p 14580829 SSKEVDPsTGELQSL activity, induced; protein stabilization; molecular association, regulation; intracellular localization; phosphorylation; enzymatic activity, induced carcinogenesis, induced; carcinogenesis, inhibited; transcription, induced; transcription, altered; signaling pathway regulation; autophagy, induced; cell growth, induced; transcription, inhibited KEAP1(INDUCES) 24011591; 24492006; 25049227; 27215388; 27245349; 28055010; 28673615; 29225212; 31035006; 31362587; 33395605; 33875681; 34087234; 34531248; 35648750; 37306101 48 0 1 regulates the KEAP1-NRF2 pathway. -PPP1R12A MYPT1 Motility/polarity/chemotaxis; PHOSPHATASE; Protein phosphatase, regulatory subunit Q90623 396020 chicken T695-p 448587 ARQSRRStQGVTLTD enzymatic activity, inhibited 12030846 66 42 226 -WTAP WTAP Nucleolus; Spliceosome Q15007 9589 6q25.3 human T148-p 36131377 ELSAWKFtPDSQTGK Wtap cell differentiation, induced 33217317 1 1 0 -ALK ALK EC 2.7.10.1; KINASE; Kinase, protein; Membrane protein, integral; Oncoprotein; Protein kinase, TK; Protein kinase, tyrosine (receptor) Q9UM73 238 2p23.2-p23.1 human Y1096-p 450375 MTDYNPNyCFAGKTS molecular association, regulation IRS2(INDUCES) 30459283 2 6 97 -IRS2 IRS2 Adaptor/scaffold; Motility/polarity/chemotaxis Q9Y4H2 8660 13q34 human S679-p 472256 SDDYMPMsPASVSAP activity, inhibited 34731634 2 22 5 -NUMA1 NuMA-1 Cell cycle regulation; Motility/polarity/chemotaxis Q14980 4926 11q13.4 human K1766-sm 15511955 ISQRLPPkVESLESL cell cycle regulation; cytoskeletal reorganization 24309115 1 3 0 maintenance of mitotic spindle in mitosis -PARN PARN EC 3.1.13.4; Nucleolus; RNA-binding; Ribonuclease O95453 5073 16p13.12 human K566-ac 466276 TAPSTVGkRNLSPSQ enzymatic activity, inhibited 32457045 1 0 23 K566 regulates levels of adenylated hTR -RNF157 RNF157 UBIQUITIN LIGASE; Ubiquitin conjugating system; Ubiquitin ligase Q96PX1 114804 17q25.1 human S663-p 5202129 RRRLSSSsLEDSETR protein degradation; molecular association, regulation; ubiquitination CDH1(INDUCES) 28655764 1 2 3 -MAP3K8 Cot EC 2.7.11.25; KINASE; Kinase, protein; Oncoprotein; Protein kinase, STE; Protein kinase, Ser/Thr (non-receptor) P41279 1326 10p11.23 human S62-p 2868603 QNDERSKsLLLSGQE enzymatic activity, induced 16806191 2 2 0 -PSIP1 LEDGF Motility/polarity/chemotaxis; Transcription, coactivator/corepressor O75475 11168 9p22.3 human K75-sm 13875713 YGKPNKRkGFNEGLW PWWP protein degradation transcription, inhibited 20382164 1 1 0 -ZNF420 ZNF420 C2H2-type zinc finger protein; Transcription factor Q8TAQ5 147923 19q13.12 human S68-p 7669300 NTYETELsQWEMSDR molecular association, regulation p53(DISRUPTS) 19377469 1 0 0 in response to DNA damage, ZNF420 (Apak) dissociates from p53 and activates p53-mediated apoptosis -RELB RELB Transcription factor Q01201 5971 19q13.32 human S472-p 36392502 DFFSGTVsLPGLEPP RelB_transactiv molecular association, regulation cell motility, induced; transcription, induced IkB-alpha(DISRUPTS) 25267645 2 0 0 MMP3 transcription -SRC Src EC 2.7.10.2; KINASE; Kinase, protein; Oncoprotein; Protein kinase, TK; Protein kinase, tyrosine (non-receptor) P12931 6714 20q11.23 human S12-p 448230 KSKPKDAsQRRRSLE molecular association, regulation; enzymatic activity, induced PPP2R2C(INDUCES) 18069897 5 1 1 interferes with PPP2R2C abitity to inhibit JNK phosphorylation following exposure to UV; in cells treated with UV -ARHGAP8 ARHGAP8 GAP; GAP, Rac/Rho; Motility/polarity/chemotaxis P85298 23779 22q13.31 human S455-p 3635677 TKPTLPPsPLMAARR activity, induced; molecular association, regulation; protein conformation cell growth, induced LAMTOR3(INDUCES); MEK1(INDUCES) 28092672 1 5 3 LAMTOR3-mediated nuclear accumulation of phospho-ERK1/2 -ERBB2 HER2 EC 2.7.10.1; KINASE; Kinase, protein; Membrane protein, integral; Oncoprotein; Protein kinase, TK; Protein kinase, tyrosine (receptor) P04626 2064 17q12 human Y877-p 448694 LDIDETEyHADGGKV PK_Tyr_Ser-Thr protein conformation; enzymatic activity, induced carcinogenesis, induced; cell differentiation, induced; apoptosis, inhibited; cell growth, altered 17030621; 19704002; 23376850; 34107301; 37324940; 37331014 25 14 111 -Dlc1 DLC1 GAP; GAP, Rac/Rho; Tumor suppressor Q9R0Z9 50768 8 A4|8 23.05 cM mouse Y702-p 1869008601 SAEDNVNyEGQSAYD RhoGAP enzymatic activity, inhibited carcinogenesis, induced; cell growth, induced; apoptosis, inhibited 31308216 1 1 0 Rho-GAP activity -ESR1 ER-alpha DNA-binding; Nuclear receptor; Transcription factor P03372 2099 6q25.1-q25.2 human S294-p 451560 RAANLWPsPLMIKRS activity, induced; protein degradation; molecular association, regulation; ubiquitination; protein conformation cell cycle regulation; transcription, induced; transcription, inhibited; transcription, altered SKP2(INDUCES); UBE3A(INDUCES); PIN1(INDUCES) DNA(DISRUPTS) 20043841; 22431515; 23390529; 23770852; 27765908; 34711683 11 4 0 -HSPB8 HSPB8 Heat shock protein Q9UJY1 26353 12q24.23 human S57-p 2201401 DWALPRLsSAWPGTL protein degradation; protein conformation 18298377 1 5 0 in vitro; decreases oligomerization and chaperone-like activity of H11 -PTK2 FAK EC 2.7.10.2; KINASE; Kinase, protein; Protein kinase, TK; Protein kinase, tyrosine (non-receptor) Q05397 5747 8q24.3 human Y397-p 447887 SVSETDDyAEIIDEE activity, induced; protein degradation; molecular association, regulation; intracellular localization; enzymatic activity, induced; phosphorylation carcinogenesis, induced; apoptosis, altered; cell motility, induced; cell adhesion, induced; cell motility, inhibited; signaling pathway regulation; cell adhesion, inhibited; cell differentiation, altered; cell growth, induced; cell motility, altered; cell growth, altered; cell differentiation, inhibited; endocytosis, altered; carcinogenesis, inhibited; transcription, induced; transcription, altered; cell differentiation, induced; apoptosis, inhibited; cell adhesion, altered; cytoskeletal reorganization RASA1(INDUCES); Src(INDUCES); SRC-1(INDUCES); PIK3R2(DISRUPTS); Src(DISRUPTS); Vimentin(INDUCES); FAK(INDUCES); PIK3R1(INDUCES) 10821872; 11035755; 11331870; 11839732; 11857088; 12084011; 12408869; 12639965; 12659633; 15077193; 15371459; 15561106; 15707572; 15944157; 16652148; 17096371; 18032789; 18437915; 18676832; 19423701; 20129247; 20160475; 20180147; 20802513; 21768358; 21876001; 23264741; 24858039; 26068982; 26530902; 26710849; 28692661; 28759036; 32049010; 32205868; 32612176; 33532186; 33674746; 33715263; 33761359; 33952697; 33981002; 33999101; 34052254; 34226698; 34240802; 34335982; 34383763; 34619327; 34858503; 35124008; 35125823; 35131384; 35201437; 35257717; 35307378; 35471457; 35594862; 35773413; 35850179; 35962191; 36797281; 36804546; 37083591; 37443754; 8824286 371 31 474 in vitro and in vivo -C5AR1 C5aR GPCR, family 1; Membrane protein, integral; Membrane protein, multi-pass; Receptor, GPCR P21730 728 19q13.32 human S338-p 448820 ESKSFTRsTVDTMAQ molecular association, regulation; receptor desensitization, altered ARRB1(INDUCES); ARRB2(INDUCES) 10636859; 12464600; 17145764 4 0 1 induces translocation of beta-arrestin into the plasma membrane -IRF3 IRF3 DNA-binding; Transcription factor Q14653 3661 19q13.33 human Y292-p 1867930600 RLGHCHTyWAVSEEL IRF-3 activity, induced transcription, induced 30842273 1 1 0 IFN-beta expression -EGFR EGFR EC 2.7.10.1; KINASE; Kinase, protein; Membrane protein, integral; Oncoprotein; Protein kinase, TK; Protein kinase, tyrosine (receptor) P00533 1956 7p11.2 human S1071-p 448052 SFLQRYSsDPTGALT receptor desensitization, altered; receptor internalization, altered 1309762; 7505275 17 2 8 -FERMT1 kindlin-1 Cytoskeletal; Motility/polarity/chemotaxis Q9BQL6 55612 20p12.3 human S174-p 3210720 LESSPTAsGSSVSPG protein degradation cell cycle regulation; cell growth, induced; apoptosis, inhibited; cytoskeletal reorganization; cell adhesion, inhibited 35469017 1 3 0 -Agtr1 AT1 GPCR, family 1; Membrane protein, integral; Membrane protein, multi-pass; Receptor, GPCR P25095 24180 17p12 rat S338-p 452092 STKMSTLsYRPSDNM activity, induced; molecular association, regulation ARRB2(INDUCES) 16831865; 29146594 5 0 0 BRET -EGFR EGFR EC 2.7.10.1; KINASE; Kinase, protein; Membrane protein, integral; Oncoprotein; Protein kinase, TK; Protein kinase, tyrosine (receptor) P00533 1956 7p11.2 human Y869-p 448061 LGAEEKEyHAEGGKV PK_Tyr_Ser-Thr activity, induced; molecular association, regulation; enzymatic activity, induced cell cycle regulation; carcinogenesis, induced; carcinogenesis, inhibited; cell motility, induced; transcription, induced; signaling pathway regulation; apoptosis, inhibited; cell motility, altered; cell adhesion, altered; cell growth, altered PKCZ(INDUCES); PKCE(INDUCES); COX2(INDUCES) 11983694; 12842895; 15282306; 15592458; 16037379; 16849545; 16862179; 17561374; 19305428; 20407013; 21787862; 28102297; 33657368; 33706413; 34088769 97 20 171 -Notch1 Notch 1 Membrane protein, integral; Motility/polarity/chemotaxis; Oncoprotein; Receptor, misc.; Transcription factor Q01705 18128 2 A3|2 18.91 cM mouse K2050-ac 18899506 NKDMQNNkEETPLFL Ank_2 protein stabilization; ubiquitination 21499261 1 1 0 -TJP1 ZO1 Adaptor/scaffold; Motility/polarity/chemotaxis Q07157 7082 15q13.1 human T770-p 30306604 KNNHHLFtTTINLNS Guanylate_kin molecular association, regulation cell adhesion, inhibited occludin(DISRUPTS) 24338688 1 0 0 15(S)-HETE or 12(S)-HETE (high fat diet) -induced endothelial tight junction (TJ) disruption -CD19 CD19 Cell surface; Membrane protein, integral P15391 930 16p11.2 human Y531-p 447639 HEEDADSyENMDNPD molecular association, regulation LYN(INDUCES); PIK3CA(INDUCES); VAV1(INDUCES) 10933394 8 3 18 -PLCG1 PLCG1 Carbohydrate Metabolism - inositol phosphate; EC 3.1.4.11; Motility/polarity/chemotaxis; Phospholipase P08487 281987 cow Y509-p 464036 NHEWYPHyFVLTSSK enzymatic activity, induced cell motility, altered; cytoskeletal reorganization; cell growth, altered PLCG1(INDUCES) 17116690 3 0 8 PLCG1 with a nonfunctional domain is constitutively active. ELISA assay showed SH2N and SH2C bound to Y132 phospho-peptide. Binding was mediated by SH2N domain. sPH blocks binding of SH2 domain to target proteins. Y509F /506F did not affect binding to pY132 LAT, but Y509A/F510A did show sigification binding. Y509A/F510A mutation showed increased NF-AT transcription, as compared to wild-type. -PKM PKM Carbohydrate Metabolism - glycolysis and gluconeogenesis; Carbohydrate Metabolism - pyruvate; EC 2.7.1.40; KINASE; Kinase, other; Mitochondrial; Nucleotide Metabolism - purine P14618 5315 15q23 human Y390-p 450529 REAEAAIyHLQLFEE PK enzymatic activity, inhibited carcinogenesis, induced; cell growth, induced 23814019 2 12 129 -SLC3A2 SLC3A2 Membrane protein, integral; Transporter P08195 6520 11q12.3 human S527-p 6003505 LSLFRRLsDQRSKER cell adhesion, altered 19065266 1 0 0 enhances cell- cell interactions -AKT1S1 PRAS40 Apoptosis Q96B36 84335 19q13.33 human T246-p 470067 LPRPRLNtSDFQKLK PRAS activity, induced; molecular association, regulation; activity, inhibited; phosphorylation cell cycle regulation; carcinogenesis, induced; cell motility, induced; signaling pathway regulation; cell growth, induced; apoptosis, inhibited; autophagy, inhibited; translation, induced 14-3-3 beta(INDUCES); Raptor(DISRUPTS); 14-3-3 eta(INDUCES); 14-3-3 beta(DISRUPTS) 12524439; 17277771; 17386266; 18215133; 18372248; 21750219; 21914810; 26009991; 34523696; 34762647; 34948236; 35058442; 35279705 50 69 781 -CBX4 CBX4 EC 6.3.2.-; SUMO LIGASE; SUMO conjugating system; SUMO ligase; Transcription, coactivator/corepressor O00257 8535 17q25.3 human T437-p 7315202 ARSISTPtCLGGSPA protein degradation; molecular association, regulation; ubiquitination carcinogenesis, inhibited; cell motility, inhibited CHIP(INDUCES) 32111827 1 1 0 increases ubiquitylation at CBX4-K178, K280 -TP63 p63 DNA-binding; Transcription factor Q9H3D4 8626 3q28 human Y171-p 10359107 AIPSNTDyPGPHSFD P53 protein stabilization 19783996 1 0 0 -E2f7 E2F7 Cell cycle regulation; DNA-binding; Transcription factor Q6S7F2 52679 10 D1|10 57.74 cM mouse S411-p 3208641 ERLVRYGsFNTVHTS molecular association, regulation cell cycle regulation; apoptosis, inhibited; transcription, induced 14-3-3 zeta(INDUCES) 29363506 1 20 14 -USF2 USF2 DNA-binding; Transcription factor Q15853 7392 19q13.12 human T230-p 3801550 PKIDGTRtPRDERRR protein stabilization; molecular association, regulation; protein conformation cell motility, induced; transcription, induced DNA(INDUCES) 25238393 1 1 3 target gene transcription of HO-1, PAI-1, and FAS -L1cam NCAM-L1 Cell adhesion; Membrane protein, integral P11627 16728 X A7.3|X 37.43 cM mouse K1172-sm 31089525 DSEARPMkDETFGEY Bravo_FIGEY cell motility, induced 24118054 1 0 0 cathepsin E-mediated genertion of a sumoylated 30 kDa L1 fragment that induces Schwann cell migration and myelination -Nfatc2 NFAT1 DNA-binding; Transcription factor Q60591 18019 2 H3|2 88.91 cM mouse S176-p 447842 LSPASSGsSASFISD transcription, inhibited 11030334 0 1 0 -Map2k1 MEK1 EC 2.7.12.2; KINASE; Kinase, protein; Protein kinase, STE; Protein kinase, dual-specificity (non-receptor) Q01986 170851 8q24 rat S222-p 448513 LIDSMANsFVGTRSY Pkinase enzymatic activity, induced 8034665; 8157000 117 20 203 -OCLN occludin Cell adhesion; Membrane protein, integral; Membrane protein, multi-pass; Motility/polarity/chemotaxis Q16625 100506658 5q13.2 human S490-p 6094300 RLKQVKGsADYKSKK Occludin_ELL protein degradation; molecular association, regulation; ubiquitination; intracellular localization cell cycle regulation; endocytosis, altered; cell growth, induced; cytoskeletal reorganization ZO1(DISRUPTS); Hrs(INDUCES); ITCH(INDUCES); epsin 1(INDUCES); EPS15(INDUCES) 19125584; 19478092; 21757728; 22438576; 31073629; 31553086 11 1 0 alters ZO-1 distribution/ degradation of tight juction protein in a p75NTR-dependent manner -Kif7 KIF7 Microtubule-binding; Motor B7ZNG0 16576 7|7 D2 mouse S1337-p 4170004 RWEPRRTsPGMIDVR intracellular localization transcription, altered; signaling pathway regulation 25492966 1 5 0 1) Localization of Gli proteins to cilicary tip 2) Hedghog pathway activation 3) Gli-mediated transcriptional output -MET Met EC 2.7.10.1; KINASE; Kinase, protein; Membrane protein, integral; Oncoprotein; Protein kinase, TK; Protein kinase, tyrosine (receptor) P08581 4233 7q31.2 human Y1313-p 450189 EYCPDPLyEVMLKCW PK_Tyr_Ser-Thr activity, induced cell motility, induced; cell growth, induced; signaling pathway regulation 21777671; 24634221 6 1 4 signaling to induce lamellipodia formation and ROS generation in lung cells; Ras/MAPK signaling pathway -MORC2 MORC2 DNA-binding Q9Y6X9 22880 22q12.2 human S739-p 3217905 ATPSRKRsVAVSDEE intracellular localization; enzymatic activity, induced cell cycle regulation; carcinogenesis, induced; DNA repair, induced; cell growth, induced; chromatin organization, altered; signaling pathway regulation 23260667; 25888627 2 37 8 proliferation of gastric cancer cells; ATM-PAK1-MORC2 pathway -PRL prolactin Cytokine; Motility/polarity/chemotaxis; Secreted; Secreted, signal peptide P01240 sheep S181-p 17790903 TEPYPVWsGLPSLQT Hormone_1 activity, induced 15684343 9 0 0 improved thermoregulation and UCP1 function -HNRNPK hnRNP K RNA splicing; RNA-binding; Spliceosome P61978 3190 9q21.32 human R299-m1 8092824 PPPGRGGrGGSRARN molecular association, regulation; phosphorylation apoptosis, inhibited PKCD(DISRUPTS) 25104022 1 4 20 methylation of R296 and R299 suppress S302 phosphorylation, R296/R299 methylation reduces apoptosis in U2OS-K- 2RK cells after DNA damage -STIM1 STIM1 Calcium-binding; Endoplasmic reticulum; Membrane protein, integral Q13586 6786 11p15.4 human S521-p 468874 RDLTHSDsESSLHMS signaling pathway regulation 31381180 1 34 7 -SATB1 SATB1 DNA-binding; Transcription factor Q01826 6304 3p24.3 human S185-p 464645 DLPPEQWsHTTVRNA CUTL molecular association, regulation; acetylation transcription, inhibited HDAC1(INDUCES); PCAF(INDUCES) DNA(INDUCES) 16630892 2 0 0 Downregulates gene expression -Rcan1 RCAN1 Inhibitor Q6IN33 266766 11q11 rat S93-p 25687504 AQTLHIGsSHLAPPN Calcipressin enzymatic activity, inhibited neural plasticity 32084406 3 2 0 inhibits calcineurin activity further causing LTP -FHL1 FHL1 iso1 Cell development/differentiation Q13642-1 2273 Xq26.3 human Y272-p 1015543 VFHQEQVyCPDCAKK LIM intracellular localization cell growth, induced BCLAF1(INDUCES) 29434030 1 1 21 translocate to the nucleus -Met Met EC 2.7.10.1; KINASE; Kinase, protein; Membrane protein, integral; Oncoprotein; Protein kinase, TK; Protein kinase, tyrosine (receptor) P16056 17295 6 A2|6 7.83 cM mouse Y1363-p 448474 NVKCVAPyPSLLPSQ molecular association, regulation cell motility, altered; cytoskeletal reorganization GRB2(INDUCES); PIK3C2A(INDUCES); GAB1(INDUCES); SHC1(INDUCES) 10069803; 7708691 8 5 116 activates cell mobility -GRB2 GRB2 Adaptor/scaffold; Cell development/differentiation; Motility/polarity/chemotaxis P62993 2885 17q25.1 human Y7-p 478849 _MEAIAKyDFKATAD SH3_1 cell growth, altered 19273609 1 0 2 regulates cell proliferation -NPM1 NPM1 Nucleolus; Oncoprotein; RNA-binding; Translation P06748 4869 5q35.1 human S4-p 452023 ____MEDsMDMDMSP intracellular localization cell cycle regulation; cytoskeletal reorganization 15190079; 20352051; 30453269 6 30 1 -ATP2A1 ATP2A1 EC 3.6.3.8; Endoplasmic reticulum; Hydrolase; Membrane protein, integral; Membrane protein, multi-pass; Transporter; Transporter, ion channel O14983 487 16p11.2 human S186-p 4764562 ILTGESVsVIKHTEP E1-E2_ATPase molecular association, regulation; enzymatic activity, induced ATP2A1(INDUCES) 19628462 1 3 0 -Aatk Lmr1 EC 2.7.11.1; KINASE; Kinase, protein; Membrane protein, integral; Protein kinase, Ser/Thr (non-receptor); Protein kinase, TK; Protein kinase, tyrosine (receptor) Q80YE4 11302 11|11 E2 mouse S614-p 456515 PCPSRSPsPGTPMLP apoptosis, induced 16100393 1 0 0 -YBX1 YB-1 RNA processing; RNA splicing; RNA-binding; Transcription factor P67809 4904 1p34.2 human T89-p 36130583 EDVFVHQtAIKKNNP CSD activity, induced; molecular association, regulation; ubiquitination; intracellular localization carcinogenesis, induced; DNA repair, induced; cell growth, induced; transcription, induced; signaling pathway regulation DNA(INDUCES) 36475703; 37328464 2 2 0 induces the TOPK/YB1/eEF1A1 signal pathway -VIL1 Villin Actin-binding; Motility/polarity/chemotaxis P09327 7429 2q35 human Y81-p 454006 EQGAAAIyTTQMDDF Gelsolin molecular association, regulation; intracellular localization cytoskeletal reorganization ACTB(INDUCES) 12269817; 15342783 3 0 0 -CD4 CD4 Cell surface; Membrane protein, integral P01730 920 12p13.31 human S433-p 451188 RRQAERMsQIKRLLS Tcell_CD4_C protein degradation; receptor internalization, altered; intracellular localization 15494497; 1674746 3 0 3 -CREBBP CBP ACETYLTRANSFERASE; Acetyltransferase; DNA-binding; EC 2.3.1.48; Motility/polarity/chemotaxis; Nuclear receptor co-regulator; Transcription, coactivator/corepressor Q92793 1387 16p13.3 human K1595-ac 461371 KNNKKTNkNKSSISR HAT_KAT11 acetylation 28630323 1 6 255 autoacetylation of CBP K1596 (autoregulatory loop (AL) of CBP) has a negative regulatory effect on acetylation of H3K27 -CD6 CD6 Cell surface; Membrane protein, integral P30203 923 11q12.2 human S482-p 28095003 PEDSDSGsDSDYEHY phosphorylation signaling pathway regulation 23711376 1 0 0 ERK1/2 phosphorylation, MAPK pathway activation -GHSR GHSR GPCR, family 1; Membrane protein, integral; Membrane protein, multi-pass; Receptor, GPCR Q92847 2693 3q26.31 human S252-p 1877127904 GDAVVGAsLRDQNHK 7tm_1 molecular association, regulation ARRB2(INDUCES) 35605660 1 0 0 -TBXA2R TXA2-R GPCR, family 1; Membrane protein, integral; Membrane protein, multi-pass; Receptor, GPCR P21731 6915 19p13.3 human S145-p 469630 FSRPAVAsQRRAWAT 7tm_1 receptor desensitization, induced signaling pathway regulation 17466390 2 0 0 -CDC26 CDC26 Q8NHZ8 246184 9q32 human T7-p 10815632 _MLRRKPtRLELKLD ANAPC_CDC26 molecular association, regulation; ubiquitination APC4(DISRUPTS); CDC16(DISRUPTS) 25723520 1 0 7 Ubiquitination of PLK1; affects APC/C assembly -SLC7A11 SLC7A11 Membrane protein, integral; Membrane protein, multi-pass; Transporter; Transporter, SLC family Q9UPY5 23657 4q28.3 human S26-p 470841 NVNGRLPsLGNKEPP intracellular localization; activity, inhibited autophagy, inhibited 28648777; 33531365 3 28 9 -MRE11 MRE11A Cell cycle regulation; DNA repair, damage; DNA-binding; Deoxyribonuclease P49959 4361 11q21 human R574-me 2344814 NKGRGRGrGRRGGRG intracellular localization 15970667 1 0 0 localizes in nucleus and associates with nuclear bodies and sites of DNA damage -PRKN PARK2 EC 6.3.2.-; EC 6.3.2.19; Ligase; Translation; Translation regulation; UBIQUITIN LIGASE; Ubiquitin conjugating system; Ubiquitin ligase O60260 5071 6q26 human S108-p 17550101 SLTRVDLsSSVLPGD ubiquitination; intracellular localization; phosphorylation; enzymatic activity, induced cell cycle regulation; autophagy, induced; autophagy, inhibited 33827825; 35642724 2 2 1 -Tbx21 TBX21 DNA-binding; Transcription factor Q9JKD8 57765 11|11 D mouse K313-ub 27930806 NAEITQLkIDNNPFA T-box protein stabilization; molecular association, regulation; phosphorylation NFAT1(INDUCES) 23616576 1 1 0 crucial for T302 phosphorylation -FOS Fos DNA-binding; Motility/polarity/chemotaxis; Oncoprotein; Transcription factor P01100 2353 14q24.3 human Y30-p 473044 AGDSLSYyHSPADSF intracellular localization cell cycle regulation; cell growth, inhibited 17160021; 22105363 2 0 0 critical for association of Fos with endoplasmic reticulum membranes and phospholipid synthesis activation; inhibits phospholipid synthesis -Crk CRK Adaptor/scaffold; Motility/polarity/chemotaxis; Oncoprotein Q64010 12928 11 B5|11 45.92 cM mouse Y221-p 447951 GGPEPGPyAQPSVNT molecular association, regulation; enzymatic activity, inhibited Abl iso4(INDUCES); CBL(INDUCES); CRK(INDUCES) 11380621; 20697350; 7700361 25 14 1168 -Erbb2 HER2 EC 2.7.10.1; KINASE; Kinase, protein; Membrane protein, integral; Oncoprotein; Protein kinase, TK; Protein kinase, tyrosine (receptor) P06494 24337 10q31 rat Y1224-p 448675 PAFDNLYyWDQNSSE molecular association, regulation apoptosis, altered SHC1(DISRUPTS); SHC1(INDUCES) 11500516; 19826412 36 1 8 inhibits apoptosis; This site can mediate transforming signals. -Adam17 TACE EC 3.4.24.86; Membrane protein, integral; Motility/polarity/chemotaxis; Protease Q9Z1K9 57027 6q16 rat T735-p 449804 KPFPAPQtPGRLQAL enzymatic activity, induced signaling pathway regulation 21411748 18 15 6 required for NGF-induced p75NTR cleavage; important for cell survival -Mef2d MEF2D DNA-binding; Transcription factor Q63943 17261 3 F1|3 38.78 cM mouse S190-p 2246701 QPALQRNsVSPGLPQ protein stabilization; molecular association, regulation; protein conformation; activity, inhibited cell differentiation, altered; transcription, inhibited HDAC9(INDUCES); ASH2L(DISRUPTS); HDAC4(INDUCES) 18299387; 23723416 2 2 0 -SHB SHB Adaptor/scaffold Q15464 6461 9p13.1 human Y297-p 458102 QHKGIQLyDTPYEPE molecular association, regulation cell motility, induced; signaling pathway regulation NCK1(INDUCES); NCK2(INDUCES) 32060095 1 9 103 regulates EphB2 signaling -YAP1 YAP1 Oncoprotein; Transcription, coactivator/corepressor P46937 10413 11q22.1 human K254-ub 964556210 YYINHKNkTTSWLDP WW protein degradation; ubiquitination cell motility, inhibited 33939216 1 1 0 TNBC cell migration and invasion -RBM15 RBM15 Oncoprotein; RNA-binding; Spliceosome Q96T37 64783 1p13.3 human R578-m2 35483228 LLYRDRDrDLYPDSD protein degradation; ubiquitination cell differentiation, inhibited; RNA splicing, inhibited 26575292 1 1 0 megakaryocyte (MK) and B cell differentiation, methylation controls the RBM15 dosage thereby controling alternative RNA splicing -PLEKHG2 PLEKHG2 GEF; GEF, misc.; Tumor suppressor Q9H7P9 64857 19q13.2 human T680-p 31836500 AIPSVPNtPSLSSTP transcription, induced; cytoskeletal reorganization 24554703 1 0 0 neurite outgrowth -Cdkn1a p21Cip1 Cell cycle regulation; Inhibitor P39689 12575 17 A3.3|17 15.12 cM mouse Y76-p 26400605 SLGLPKVyLSPGSRS carcinogenesis, induced; cell growth, induced 23007395 1 0 0 -UPF1 RENT1 C2H2-type zinc finger protein; EC 3.6.1.-; EC 3.6.4.-; Hydrolase; RNA-binding Q92900 5976 19p13.11 human T151-p 50788283 FCNGRGNtSGSHIVN UPF1_Zn_bind molecular association, regulation; protein conformation; enzymatic activity, induced RNA stability, inhibited ELF4(DISRUPTS); UPF2(DISRUPTS); UPF3B(DISRUPTS); CTIF(DISRUPTS) 35675814 1 2 0 -CTTN Cortactin Actin-binding; Cytoskeletal; Motility/polarity/chemotaxis Q14247 2017 11q13.3 human Y421-p 447702 RLPSSPVyEDAASFK molecular association, regulation carcinogenesis, induced; cell motility, induced; cell adhesion, altered; cytoskeletal reorganization N-WASP(INDUCES) 15056655; 21696810; 24188565; 25682866; 29133485; 32005974; 34088320; 36258022; 9748248 47 62 745 -Cbx7 CBX7 Transcription regulation Q8VDS3 52609 15 E1|15 37.85 cM mouse T119-p 29669800 TNGPPPWtPTLPSSE CBX7_C molecular association, regulation transcription, inhibited PCGF2(INDUCES); RNF2(INDUCES); BMI1(INDUCES) 24194518 1 1 0 enhances p16 repression -SP1 SP1 C2H2-type zinc finger protein; DNA-binding; Transcription factor P08047 6667 12q13.13 human S491-gl 4283200 LAPMQGVsLGQTSSS molecular association, regulation transcription, induced SP1(DISRUPTS) 9343410 3 1 0 -HIF1A HIF1A Autophagy; DNA-binding; Transcription factor Q16665 3091 14q23.2 human T455-p 31887953 LAMSPLPtAETPKPL protein stabilization; molecular association, regulation; ubiquitination carcinogenesis, induced; cell growth, induced; transcription, induced EGLN1(DISRUPTS) 34211090 3 4 0 inhibits ubiquitination -UBA52-RPS27A-UBB-UBC ubiquitin Ubiquitin-like modifier P62988 2p16 human S57-p 448541 LEDGRTLsDYNIQKE ubiquitin enzymatic activity, induced 27425610 1 30 0 modest effects on UBE3C ligase activity -NFYA NFYA DNA-binding; Transcription factor P23511 4800 6p21.1 human S320-p 23254175 GEGGRFFsPKEKDSP molecular association, regulation; intracellular localization cell cycle regulation; transcription, induced DNA(DISRUPTS) 30589568 1 2 1 -SH2B1 SH2-B-beta Adaptor/scaffold Q9NRF2 25970 16p11.2 human S161-p 21336502 SLRSVGRsVRGSVRG intracellular localization cell motility, induced; cell adhesion, altered 21878491 2 0 2 regulates focal adhesion size and number -Ndel1 NDEL1 Microtubule-binding; Protease Q9ERR1 83431 11|11 B3 mouse S251-p 474509 LTPSARIsALNIVGD NUDE_C intracellular localization cytoskeletal reorganization 17060449; 25698733 2 1 0 impaired transport of DISC1and PAFAH1B1 to neurite tips, inhibited microtuble elongation; important for centrosome separation during mitosis -EPOR EPOR Membrane protein, integral; Receptor, cytokine P19235 2057 19p13.2 human Y368-p 449883 SEHAQDTyLVLDKWL activity, induced; molecular association, regulation; phosphorylation cell cycle regulation; apoptosis, inhibited; transcription, altered; signaling pathway regulation; cell growth, altered STAT5A(INDUCES); SOCS3(INDUCES) 10455108; 11290583; 12027890; 12506011; 14662339; 15878737; 19187767; 8657137 17 0 0 promotes STAT5 and JAK2 phosphorylation; activates Stat5 -RIGI RIGI EC 3.6.4.13; Hydrolase O95786 23586 9p21.1 human S8-p 12613701 MTTEQRRsLQAFQDY CARD_2 molecular association, regulation; ubiquitination; enzymatic activity, inhibited; intracellular localization; activity, inhibited transcription, induced; transcription, inhibited TRIM25(DISRUPTS); MAVS(DISRUPTS) RNA(INDUCES) 20406818; 22114345; 23264040; 23499489; 24371060; 28250012; 34935440; 36113429 9 6 0 -NDE1 NUDE1 iso1 Cell cycle regulation; Cytoskeletal; Microtubule-binding Q9NXR1-1 54820 16p13.11 human T191-p 20722719 QKQEKPRtPMPSSVE NUDE_C protein degradation; molecular association, regulation; intracellular localization FBXW7(INDUCES); ZNF365(DISRUPTS) 16682949; 26206584 2 4 0 colocalization at centrosome, regulation of ciliary length -BRAF BRAF EC 2.7.11.1; KINASE; Kinase, protein; Oncoprotein; Protein kinase, Ser/Thr (non-receptor); Protein kinase, TKL P15056 673 7q34 human S614-p 14159399 SHQFEQLsGSILWMA PK_Tyr_Ser-Thr molecular association, regulation; enzymatic activity, inhibited MEK1(DISRUPTS) 27345148 2 2 0 -MST1R Ron EC 2.7.10.1; KINASE; Kinase, protein; Membrane protein, integral; Protein kinase, TK; Protein kinase, tyrosine (receptor) Q04912 4486 3p21.31 human Y1198-p 456482 QVARGMEyLAEQKFV PK_Tyr_Ser-Thr enzymatic activity, induced transcription, induced 24739671 2 0 0 relieves inhibition on Ron activation imposed by the JM-C region -ETV4 ETV4 DNA-binding P43268 2118 17q21.31 human K96-sm 3144816 HSPTTRIkKEPQSPR ETS_PEA3_N transcription, inhibited 17585876 4 1 0 -HIPK2 HIPK2 EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, CMGC; Protein kinase, Ser/Thr (non-receptor) Q9H2X6 28996 7q34 human K32-sm 1727700 FCSVKKLkIEPSSNW protein degradation; molecular association, regulation; intracellular localization; phosphorylation; enzymatic activity, induced transcription, induced; transcription, inhibited TLE1(DISRUPTS) 15766567; 15896780; 17018294 3 1 0 K32A (aka K25A) mutant increases phosphorylation of CBX4 -L1CAM NCAM-L1 Cell adhesion; Membrane protein, integral P32004 3897 Xq28 human S1248-p 472277 NDSSGATsPINPAVA molecular association, regulation cytoskeletal reorganization; cell adhesion, inhibited ANK3(INDUCES) 17151951; 21080252; 23431142; 29109170 5 12 0 L1 sensitivity to ethanol; S1248 phosphorylation is necessary for ethanol inhibition of adhesion. -CTNNB1 CTNNB1 Actin-binding; Cell adhesion; Motility/polarity/chemotaxis; Nuclear receptor co-regulator; Oncoprotein; Transcription factor P35222 1499 3p22.1 human S605-p 3545003 LFVQLLYsPIENIQR Arm molecular association, regulation; protein stabilization; intracellular localization; protein conformation cell growth, induced; transcription, induced PIN1(INDUCES) 25961922; 26740630 3 0 0 nuclear retention -Adcy2 ADCY2 Adenylyl cyclase; EC 4.6.1.1; Lyase; Membrane protein, integral; Membrane protein, multi-pass; Nucleotide Metabolism - purine; Transporter; Transporter, aquaporin family P26769 81636 1p11 rat S543-p 25795202 NRTLRTKsQKKRFEE Adcy_cons_dom activity, induced 22906005 1 1 0 cAMP release -Runx2 AML3 DNA-binding; Transcription factor Q08775 12393 17 B3|17 21.33 cM mouse S326-p 460575 KLDDSKPsLFSDRLS activity, induced transcription, induced 16421932 1 0 0 -FUS hnRNP P2 DNA-binding; Nuclear receptor co-regulator; Oncoprotein; RNA splicing; RNA-binding; SUMO LIGASE P35637 2521 16p11.2 human S84-p 3306336 STGGYGSsQSSQSSY molecular association, regulation 28942918 5 1 0 strongly reduced the effects of DNA-PK treatment on both hydrogel binding and droplet formation -Pxn PXN Adaptor/scaffold; Cell adhesion; Cytoskeletal; Motility/polarity/chemotaxis Q8VI36 19303 5 F|5 56.1 cM mouse Y31-p 448785 FLSEEPPySYPTGNH activity, induced; molecular association, regulation; phosphorylation apoptosis, altered; apoptosis, inhibited; cell adhesion, induced; cell motility, altered; cytoskeletal reorganization; cell adhesion, altered RASA1(INDUCES); Vinculin(INDUCES) 12446743; 15107421; 15138291; 20308429; 30604146 49 8 64 -CCR5 CCR5 GPCR, family 1; Membrane protein, integral; Membrane protein, multi-pass; Motility/polarity/chemotaxis; Receptor, GPCR; Receptor, cytokine P51681 1234 3p21.31 human S342-p 449902 ASSVYTRsTGEQEIS molecular association, regulation; receptor desensitization, altered; receptor internalization, altered ARRB1(INDUCES); ARRB2(INDUCES) 10085131; 11782464; 12065593 3 0 0 -BAIAP2L1 IRTKS Adaptor/scaffold; Cytoskeletal Q9UHR4 55971 7q21.3-q22.1 human Y293-p 472861 PAPSGRAyTSPLIDM cell motility, induced 21840312 1 0 21 -SRSF1 SF2 RNA splicing; RNA-binding; Spliceosome Q07955 6426 17q22 human S119-p 27106000 YGPPSRRsENRVVVS molecular association, regulation; activity, inhibited RNA splicing, inhibited RNA(INDUCES) 22393468 1 3 0 -USF1 USF1 DNA-binding; Transcription factor P22415 7391 1q23.3 human S309-p 40515061 EVVIKNDsN______ molecular association, regulation transcription, inhibited DNA(DISRUPTS) 36534975 1 5 0 -CDCA8 Borealin Cell cycle regulation; Nucleolus Q53HL2 55143 1p34.3 human T169-p 4203202 KRSSRANtVTPAVGR Borealin cell cycle regulation; cytoskeletal reorganization 18243099 2 1 0 chromosome alignment in mitosis -EIF4G1 eIF4G RNA-binding; Translation; Translation initiation Q04637 1981 3q27.1 human S1185-p 482920 RTPATKRsFSKEVEE molecular association, regulation; enzymatic activity, induced signaling pathway regulation Mnk1(INDUCES) 21576361 3 51 136 PKC-Ras-Erk pathway -Slc1a2 GLT1 Membrane protein, integral; Membrane protein, multi-pass; Transporter; Transporter, SLC family P31596 29482 3q32 rat K558-ub 4667701 VTLAANGkSADCSVE receptor internalization, induced; protein degradation 18805448 1 1 0 -ARRB2 ARRB2 Adaptor/scaffold P32121 409 17p13.2 human Y64-p 1883582900 TLTCAFRyGREDLDV Arrestin_N activity, induced; molecular association, regulation; protein conformation carcinogenesis, induced RKHD4(INDUCES); IGF1R(INDUCES) 37521868 1 0 0 -RUNX1 AML1 DNA-binding; Oncoprotein; Transcription factor Q01196 861 21q22.12 human T273-p 454403 SPSVHPAtPISPGRA molecular association, regulation; phosphorylation CBFB(INDUCES) 18695000 6 1 8 promotes AML1 and p300 phosphorylation -Sorbs1 SORBS1 iso5 Cell adhesion; Cytoskeletal; Motility/polarity/chemotaxis Q62417-5 20411 19 C3|19 34.25 cM mouse Y326-p 460519 RAEPKSIyEYQPGKS cell motility, altered 19891780 1 6 250 mutation of this site inhibits cell spreading -TRPV4 TRPV4 Channel, cation; Membrane protein, integral; Membrane protein, multi-pass Q9HBA0 59341 12q24.11 human T175-p 10272405 GLLPFLLtHKKRLTD activity, induced 19661060 1 0 0 -SLC1A2 GLT1 Membrane protein, integral; Membrane protein, multi-pass; Transporter; Transporter, SLC family P43004 6506 11p13 human K571-sm 12004400 SVEEEPWkREK____ molecular association, regulation; intracellular localization PML(INDUCES) 17823119 1 0 0 -Slc18a3 SLC18A3 Membrane protein, integral; Membrane protein, multi-pass; Transporter; Transporter, SLC family Q62666 60422 16p16 rat S480-p 450965 GLLTRSRsERDVLLD intracellular localization 10748073; 10769030 2 2 2 S480 phosphorylation increases the targeting of VAChT to large dense core vesicles. -AKAP8 AKAP8 Adaptor/scaffold; Cell cycle regulation; Mitochondrial; RNA-binding O43823 10270 19p13.12 human Y152-p 7366805 PYRPSYSyDYEFDLG molecular association, regulation 25770215 2 0 0 Phenylalanine mutants inhibited dissociation from nuclear structures; structural chromatin changes -FOXA2 FOXA2 DNA-binding; Transcription factor Q9Y261 3170 20p11.21 human K259-ac 27583504 QKRFKCEkQLALKEA protein stabilization; intracellular localization transcription, induced 23416070; 24875183 2 2 0 -Usp20 USP20 DEUBIQUITINASE; EC 3.4.19.12; Protease; Ubiquitin conjugating system; Ubiquitin-specific protease Q8C6M1 74270 2|2 B mouse S132-p 469013 AVADEGEsESEDDDL protein stabilization; molecular association, regulation; ubiquitination signaling pathway regulation AMFR(INDUCES) 33177714 2 53 2 inhibits ubiquitination of HMGCR thus stabilizing it, regulates the mTORC1?USP20?HMGCR pathway -G3BP2 G3BP-2 Adaptor/scaffold; Motility/polarity/chemotaxis; RNA-binding Q9UN86 9908 4q21.1 human T226-p 3072179 EELEEKStTPPPAEP ubiquitination carcinogenesis, induced; apoptosis, inhibited 35589951 1 10 0 induces p53 ubiquitination and degradation -PLK1 PLK1 EC 2.7.11.21; KINASE; Kinase, protein; Protein kinase, Other; Protein kinase, Ser/Thr (non-receptor) P53350 5347 16p12.2 human Y425-p 62370600 SDKYGLGyQLCDNSV POLO_box protein stabilization; molecular association, regulation cell cycle regulation AurA(INDUCES) 27899378 1 1 0 Y425 phosphorylation inhibits ubiquitination and degradation -Ppp2ca PPP2CA EC 3.1.3.16; Motility/polarity/chemotaxis; PHOSPHATASE; Protein phosphatase, Ser/Thr (non-receptor) P63330 19052 11|11 B1.3 mouse L309-me 3627520 RRTPDYFl_______ enzymatic activity, inhibited cytoskeletal reorganization; cell motility, inhibited 22729898 10 0 0 astrocyte migration (motility) inhibited; AB accumulation ; activation of P38 MAPK abolishes astrocyte migration; PP2A activity inhibited -TFAM TFAM DNA-binding; Transcription regulation Q00059 7019 10q21.1 human S55-p 18016712 SCPKKPVsSYLRFSK HMG_box protein degradation; intracellular localization transcription, inhibited DNA(DISRUPTS) 23201127 1 2 0 localized to mitochondria, Lon-mediated degradation -HSP90AA1 HSP90A Chaperone; Heat shock protein P07900 3320 14q32.31 human T725-p 3180216 PLEGDDDtSRMEEVD protein stabilization; molecular association, regulation carcinogenesis, induced; cell growth, induced HOPX(INDUCES); CHIP(DISRUPTS) 22824801 1 1 0 cell proliferation increased -CEP55 CEP55 Cancer Testis Antigen (CTA); Cell cycle regulation Q53EZ4 55165 10q23.33 human S425-p 457628 NREKVAAsPKSPTAA activity, induced; molecular association, regulation cell cycle regulation PLK1(INDUCES) 16198290 1 23 8 -FLT1 VEGFR1 EC 2.7.10.1; KINASE; Kinase, protein; Membrane protein, integral; Protein kinase, TK; Protein kinase, tyrosine (receptor) P17948 2321 13q12.3 human Y1169-p 448208 VQQDGKDyIPINAIL molecular association, regulation PLCG1(INDUCES) 9299537 1 0 6 -Fyn Fyn EC 2.7.10.2; KINASE; Kinase, protein; Oncoprotein; Protein kinase, TK; Protein kinase, tyrosine (non-receptor) P39688 14360 10 B1|10 20.51 cM mouse Y531-p 447883 FTATEPQyQPGENL_ enzymatic activity, inhibited endocytosis, induced; signaling pathway regulation 16339530; 35500650 19 15 1040 induces JNK signaling -JAK3 JAK3 EC 2.7.10.2; KINASE; Kinase, protein; Protein kinase, TK; Protein kinase, tyrosine (non-receptor) P52333 3718 19p13.11 human Y841-p 1881548602 GSVELCRyDPLGDNT molecular association, regulation; protein conformation; enzymatic activity, induced Other(DISRUPTS) 37109511 2 0 0 -KCNQ1 Kv7.1 Channel, potassium; Membrane protein, integral; Membrane protein, multi-pass P51787 3784 11p15.5-p15.4 human S577-p 456165 PSLFISVsEKSKDRG KCNQ_channel activity, induced 12879210 1 0 0 -BCL3 Bcl-3 Apoptosis; Nuclear receptor co-regulator; Oncoprotein; Transcription regulation P20749 602 19q13.32 human S406-p 3627522 PSSSPSQsPPRDPPG protein degradation; molecular association, regulation; ubiquitination transcription, altered; cell growth, altered HDAC6(INDUCES); HDAC3(INDUCES); HDAC1(INDUCES) 15469820 1 0 0 -Pik3r1 PIK3R1 KINASE; Kinase, lipid; Motility/polarity/chemotaxis P26450 18708 13 D1|13 53.92 cM mouse S361-p 20831300 TFLVRDAsTKMHGDY SH2 molecular association, regulation signaling pathway regulation 21825134 1 1 0 impairs PI3K pathway activation; inhibits binding to to phospho-Tyr peptides -RELA NFkB-p65 DNA-binding; Nuclear receptor co-regulator; Transcription factor Q04206 5970 11q13.1 human S281-p 456219 RPSDRELsEPMEFQY RHD_dimer protein degradation; molecular association, regulation; ubiquitination; intracellular localization transcription, induced; transcription, altered FBXW2(INDUCES) Other(INDUCES); DNA(INDUCES) 17991436; 18025230; 23100252; 34465889; 35164343 7 0 0 induces binding to Globospiramine and roscovitine -JUN Jun Oncoprotein; Transcription factor P05412 3725 1p32.1 human K254-sm 3289001 MESQERIkAERKRMR bZIP_1 intracellular localization transcription, inhibited 16055710 2 0 0 intranuclear distribution -Sik2 QIK EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, CAMK; Protein kinase, Ser/Thr (non-receptor) Q3LRT3 315649 8q23 rat S586-p 3212040 FREGRRAsDTPLTQG apoptosis, altered 21220102 4 35 17 overexpression of S587A increases cell death -MALT1 MALT1 Adaptor/scaffold; Apoptosis; EC 3.4.22.-; Ligase; Nuclear export; Protease; UBIQUITIN LIGASE; Ubiquitin conjugating system Q9UDY8 10892 18q21.32 human S816-p 1870751200 DEIPFSFsDRLRISE carcinogenesis, induced; cell growth, induced; transcription, induced; signaling pathway regulation 31644910 0 1 0 activates transcription of NF-kB -EZH2 EZH2 EC 2.1.1.43; METHYLTRANSFERASE; Methyltransferase; Methyltransferase, protein lysine Q15910 2146 7q36.1 human T261-p 63280110 GALPPECtPNIDGPN protein degradation cell motility, inhibited; transcription, inhibited 28242758 1 0 0 -LAT LAT Adaptor/scaffold; Membrane protein, integral O43561 27040 16p11.2 human K52-ub 31914109 YPRGIQFkRPHTVAP LAT signaling pathway regulation 23514740 2 1 0 TCR signaling -AGTR1 AT1 GPCR, family 1; Membrane protein, integral; Membrane protein, multi-pass; Receptor, GPCR P30556 185 3q24 human T336-p 467237 NLSTKMStLSYRPSD activity, induced; molecular association, regulation; intracellular localization; receptor internalization, altered ARRB1(INDUCES); ARRB2(INDUCES) 11579203; 15177932 3 0 0 -ITGB5 ITGB5 Cell adhesion; Membrane protein, integral; Motility/polarity/chemotaxis P18084 3693 3q21.2 human S759-p 14694704 REFAKFQsERSRARY Integrin_b_cyt cell motility, altered 20507994 1 0 0 -Lepr LEPR Membrane protein, integral; Receptor, cytokine P48356 16847 4 C6|4 46.96 cM mouse Y1077-p 451292 HREKSVCyLGVTSVN activity, induced; molecular association, regulation; phosphorylation transcription, altered SOCS3(INDUCES) 11108838; 15634336; 20059770 7 0 0 attenuation of STAT3 phosphorylation -NFE2L2 NRF2 DNA-binding; Transcription factor Q16236 4780 2q31.2 human K536-ac 7106310 LDHLKDEkEKLLKEK bZIP_Maf molecular association, regulation transcription, induced DNA(INDUCES) 19273602 1 1 0 -RAPGEF1 RAPGEF1 GEF; GEF, Ras; Motility/polarity/chemotaxis Q13905 2889 9q34.13 human Y554-p 1870440700 KNKHMLAyMQLLEDY molecular association, regulation; enzymatic activity, induced CDC25A(INDUCES) 32873726 1 0 0 induces Rap1, LFA1 and IL3 activation -H2AX H2AX DNA repair, damage; DNA-binding; Helicase P16104 3014 11q23.3 human S16-p 33703202 KARAKAKsRSSRAGL Histone protein stabilization; ubiquitination carcinogenesis, inhibited; cell growth, inhibited; transcription, induced; cell motility, inhibited 21224359; 33574926 2 0 0 -PLAG1 PLAG1 C2H2-type zinc finger protein; DNA-binding; Oncoprotein; Transcription factor Q6DJT9 5324 8q12.1 human K244-sm 3568000 NQELLKVkTEPVDFL intracellular localization cell growth, induced; transcription, inhibited 15208321; 16207715 2 0 0 -FCGR2A FCGR2A Cell surface; Membrane protein, integral; Receptor, misc. P12318 2212 1q23.3 human Y240-p 2906102 AAVVALIyCRKKRIS TM receptor internalization, altered 15075346 1 0 0 -CDK11B CDK11B Apoptosis; Cell cycle regulation; EC 2.7.11.22; KINASE; Kinase, protein; Motility/polarity/chemotaxis; Protein kinase, CMGC; Protein kinase, Ser/Thr (non-receptor) P21127 984 1p36.33 human S752-p 468448 QRVKRGTsPRPPEGG molecular association, regulation RNA splicing, induced CDK11B(INDUCES) 23178491 1 50 8 promotes pre-mRNA splicing -TBC1D7 TBC1D7 GAP; GAP, Rab Q9P0N9 51256 6p24.1 human S124-p 15415675 GKLPRSPsFPLEPDD protein stabilization; molecular association, regulation signaling pathway regulation 14-3-3 zeta(INDUCES) 30143532 1 1 1 Binding of 14-3-3 to S124 phosphorylated TBC1D7 prevents binding of Beta-TrCP2 consequently ubiquitination of TBC1D7. -CTTN Cortactin Actin-binding; Cytoskeletal; Motility/polarity/chemotaxis Q14247 2017 11q13.3 human K319-ac 482877 VQKDRMDkNASTFED HS1_rep molecular association, regulation; intracellular localization cell motility, inhibited ACTB(DISRUPTS) 17643370 1 1 0 Acetylation prevents localization to membrane ruf?es. -AKAP1 AKAP1 Adaptor/scaffold; Membrane protein, integral; Mitochondrial; RNA-binding Q92667 8165 17q22 human S159-p 465541 PKGVLFSsKSAEVCK molecular association, regulation PPP1CA(DISRUPTS) 16669629 1 0 2 -Csf2rb CSF2RB Membrane protein, integral; Receptor, cytokine P26955 12983 15 E1|15 37.36 cM mouse S603-p 448463 LGPPQSHsLPDLPDQ molecular association, regulation cell growth, altered 14-3-3 zeta(INDUCES); PIK3R1(INDUCES) 16437163 6 1 0 Phosphorylation of Y595 and S603 are exclusive. S603 phosphorylation induces binding to 14-3-3 and prevents binding to Shc. -NOS3 eNOS Amino Acid Metabolism - arginine and proline; EC 1.14.13.39; Oxidoreductase P29473 287024 cow S1181-p 467802 RIRTQSFsLQERHLR molecular association, regulation; enzymatic activity, induced HSP90A(INDUCES) 28654706 11 8 1 enhanced eNOS affinity to all eNOS cofactors, including L-arginine, NADPH, CaM/ Ca2+and BH4. -Tp53 p53 Activator; DNA-binding; Motility/polarity/chemotaxis; Nuclear receptor co-regulator; Transcription factor; Tumor suppressor P02340 22059 11 B3|11 42.83 cM mouse K379-ub 464658 QSTSRHKkTMVKKVG transcription, altered 15964796 10 0 0 p53K6R (K378/383/369/379/367/370/R) mutant is still ubiquitinated and shows normal stability of p53 before and after DNA damage -PAK3 PAK3 EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, STE; Protein kinase, Ser/Thr (non-receptor) O75914 5063 Xq23 human S50-p 448125 NKKARLRsIFPGGGD cytoskeletal reorganization 17077177 2 1 0 Mutation of any of the 4 serines/threonines to alanine reduced the AILIM/ICOS-induced elongation ratio in activated T cells. Three sites are believed to be autophosphorylation sites, and one is believed to be an Akt1 site. Treatment with Akt inhibitor shows a reduction in this elongation ratio. -Ppp1r9b Spinophilin Adaptor/scaffold; Protein phosphatase, regulatory subunit O35274 84686 10q26 rat S177-p 448727 LLRQERAsLQDRKLD molecular association, regulation; intracellular localization endocytosis, induced ADRA2A(DISRUPTS) 12417592; 18367453; 23965992 3 1 0 -Crebbp CBP ACETYLTRANSFERASE; Acetyltransferase; DNA-binding; EC 2.3.1.48; Motility/polarity/chemotaxis; Nuclear receptor co-regulator; Transcription, coactivator/corepressor P45481 12914 16 A1|16 2.4 cM mouse T1872-p 474502 LMRRRMAtMNTRNVP transcription, induced 17166829 3 0 0 -PCNA PCNA Cell cycle regulation; DNA replication P12004 5111 20p12.3 human K164-sm 1316800 AVVISCAkDGVKFSA PCNA_C DNA repair, altered 16957771 3 2 0 promote DNA-damage independent spontaneous mutagenesis during replication-defects -ERBB4 HER4 EC 2.7.10.1; KINASE; Kinase, protein; Membrane protein, integral; Protein kinase, TK; Protein kinase, tyrosine (receptor) Q15303 2066 2q34 human Y733-p 457838 SGAFGTVyKGIWVPE PK_Tyr_Ser-Thr molecular association, regulation SHC1(INDUCES) 16729043 1 14 149 -SMARCAL1 SMARCAL1 EC 3.6.1.-; EC 3.6.4.-; Helicase Q9NZC9 50485 2q35 human S652-p 23146560 RLKSDVLsQLPAKQR SNF2-rel_dom intracellular localization; enzymatic activity, inhibited 23873943 1 2 1 induce DNA replication and regulates Genome integrity; prevent aberrant fork processing -PDE3A PDE3A EC 3.1.4.17; Membrane protein, integral; Membrane protein, multi-pass; Nucleotide Metabolism - purine; Phosphodiesterase Q14432 5139 12p12.2 human S312-p 456900 SKSHRRTsLPCIPRE enzymatic activity, induced 19261611 4 22 1 -Srebf1 SREBP-1 iso4 DNA-binding; Membrane protein, integral; Membrane protein, multi-pass; Transcription factor Q9WTN3-4 20787 11|11 B2 mouse S329-p 7996201 KSLKDLVsACGSGGG molecular association, regulation; activity, inhibited transcription, altered DNA(DISRUPTS) 19244231 1 0 0 regulates hepatic lipogenesis -Mapt Tau ACETYLTRANSFERASE; Acetyltransferase; Cytoskeletal P10637 17762 11 67.79 cM|11 E1 mouse T497-p 447933 SSPGSPGtPGSRSRT molecular association, regulation; protein conformation neural plasticity Tau(INDUCES) 33428131; 34220446; 34453977; 36186135 142 27 26 -Ntrk2 TrkB EC 2.7.10.1; KINASE; Kinase, protein; Membrane protein, integral; Protein kinase, TK; Protein kinase, tyrosine (receptor) Q63604 25054 17p14 rat K811-ub 2885000 TLLQNLAkASPVYLD phosphorylation signaling pathway regulation 18457658 1 0 0 NGF induced MAPK and Akt activation -MYB Myb DNA-binding; Oncoprotein; Transcription factor P01103 396244 chicken S116-p 448757 KYGPKRWsVIAKHLK Myb_DNA-binding molecular association, regulation transcription, inhibited DNA(DISRUPTS) 12456674 1 0 0 -Cttn Cortactin Actin-binding; Cytoskeletal; Motility/polarity/chemotaxis NP_001385572 60465 1q41-q42 rat Y421-p 447702 RPPSSPIyEDAAPLK carcinogenesis, induced; cell motility, induced; cell motility, altered; cell adhesion, altered; signaling pathway regulation 15383621; 16905744; 21725361 47 62 745 -PINX1 PINX1 Inhibitor; Nucleolus; Tumor suppressor Q96BK5 54984 8p23.1 human S117-p 14823407 SFSLEEKsKISKNRV protein degradation; ubiquitination 20573420 1 1 0 -ELK4 ELK4 DNA-binding; Transcription, coactivator/corepressor P28324 2005 1q32.1 human K125-ac 1875199900 KDVENGGkDKPPQPG molecular association, regulation transcription, induced BRD2(INDUCES) 32398865 1 1 0 -Cnr1 CNR1 GPCR, family 1; Membrane protein, integral; Membrane protein, multi-pass; Receptor, GPCR P20272 25248 5q21 rat S317-p 450999 IQRGTQKsIIIHTSE 7tm_1 activity, inhibited 9526000 1 5 2 Phosphorylation of CB1 at S317 suppressed modulation of ion channels by this receptor. -FZD2 FZD2 GPCR, Fz/Smo family; Membrane protein, integral; Membrane protein, multi-pass; Motility/polarity/chemotaxis; Receptor, GPCR Q14332 2535 17q21.31 human Y552-p 36744501 LHSWRKFyTRLTNSR Frizzled molecular association, regulation carcinogenesis, induced; cell motility, induced Fyn(INDUCES) 25417160 1 0 0 -Jund JunD Motility/polarity/chemotaxis; Transcription factor P52909 24518 16p14 rat S100-p 456168 LGLLKLAsPELERLI Jun transcription, induced 11719525; 17133482 5 63 12 -Slc6a3 DAT Membrane protein, integral; Membrane protein, multi-pass; Transporter; Transporter, SLC family P23977 24898 1p11 rat C580-pa 50592107 IYATYKFcSLPGSFR SNF intracellular localization 26424792 1 0 0 Ser7 phosphorylation and increased transport correlates with Cys580 palmitoylation, differentially modulate DA transport Vmax, presence of phosphorylation and palmitoylation on cell surface transporters -Pdc phosducin G protein regulator, misc. P20942 25343 13q21 rat S6-p 10431700 __MEEAAsQSLEEDF Phosducin molecular association, regulation G-gamma 2(DISRUPTS); G-beta 1(DISRUPTS) 11331285 1 0 0 -SH3BP4 SH3BP4 Cell cycle regulation; Vesicle Q9P0V3 23677 2q37.2 human S246-p 3214461 FRSKRSYsLSELSVL molecular association, regulation; intracellular localization cytoskeletal reorganization; signaling pathway regulation; endocytosis, inhibited 14-3-3 beta(INDUCES); EPS15(DISRUPTS); 14-3-3 epsilon(INDUCES); GIPC1(DISRUPTS) 33761321 2 39 0 binding to GPC1 regulates GPC1-NRP1 binding, regulates semaphorin signaling -LBR LBR DNA-binding; Membrane protein, integral; Membrane protein, multi-pass G1N806 turkey S80-p 14575427 SRRSRSRsRSRSPGR molecular association, regulation; protein conformation H3(INDUCES) 22056509 2 11 4 -IKBKB IKKB EC 2.7.11.10; KINASE; Kinase, protein; Protein kinase, Other; Protein kinase, Ser/Thr (non-receptor) O14920 3551 8p11.21 human K163-ub 486348 GEQRLIHkIIDLGYA Pkinase activity, induced; phosphorylation signaling pathway regulation 16267042 1 0 0 induces phosphorylation and activation of IKKB and it's substrates, regulation of signaling from cell surface TNF-R1 -RBM28 RBM28 Nucleolus; RNA splicing; RNA-binding Q9NW13 55131 7q32.1 human S122-p 3245387 RLIIRNLsFKCSEDD RRM_1 intracellular localization 34953860 1 4 0 -Dlg4 PSD-95 Adaptor/scaffold P31016 29495 10q24 rat S415-p 456446 REQLMNSsLGSGTAS protein conformation CRIPT(DISRUPTS) 21965656 1 10 0 Y397E mutant showed dissociation, triple mutant Y397E/S415E/S418E showed stronger dissociation -ABCA4 ABCA4 Membrane protein, integral; Membrane protein, multi-pass; Transporter; Transporter, ABC family P78363 24 1p22.1 human S1185-p 20940702 SCSSKGFsTTCPAHV enzymatic activity, induced 21721517 1 1 0 -Syk Syk EC 2.7.10.2; KINASE; Kinase, protein; Protein kinase, TK; Protein kinase, tyrosine (non-receptor) P48025 20963 13 A5|13 27.41 cM mouse Y519-p 447661 ALRADENyYKAQTHG PK_Tyr_Ser-Thr enzymatic activity, inhibited; phosphorylation; enzymatic activity, induced transcription, induced 27609517; 33761438; 35196496; 36166754 50 8 76 -Jak2 JAK2 EC 2.7.10.2; KINASE; Kinase, protein; Oncoprotein; Protein kinase, TK; Protein kinase, tyrosine (non-receptor) Q62120 16452 19 C1|19 23.73 cM mouse Y637-p 470140 KFGSLDTyLKKNKNS PK_Tyr_Ser-Thr enzymatic activity, induced 19364823 3 1 1 -Trp53 p53 iso2 Activator; DNA-binding; Motility/polarity/chemotaxis; Nuclear receptor co-regulator; Transcription factor; Tumor suppressor Q80ZA1 22059 11 B3|11 42.83 cM mouse S18-p 447490 ISLELPLsQETFSGL P53_TAD carcinogenesis, altered; cell motility, altered 21980358 480 12 0 decrease in the growth of p53S18A MEFs with the loss of Atm, lymphomas in 100% Atm-/-, p53 S18A/S18A mice -HSPA1A HSP70 Chaperone; Heat shock protein; Motility/polarity/chemotaxis P0DMV8 3303 6p21.33 human K126-ac 31089501 ISSMVLTkMKEIAEA HSP70 sumoylation autophagy, induced 23569248 1 1 0 acetylation induces sumoylation of PIK3C3 -IL22RA1 IL22RA1 Membrane protein, integral Q8N6P7 58985 1p36.11 human Y301-p 3579176 SLAQPVQySQIRVSG molecular association, regulation SHP-2(INDUCES) 20671117 1 1 5 necessary for IL22RA1 to mediate the IL-22-stimulated MAP kinases and STAT3 activation -VIM Vimentin Cytoskeletal; Motility/polarity/chemotaxis P08670 7431 10p13 human K97-ub 12306336 DAINTEFkNTRTNEK Filament_head protein degradation carcinogenesis, inhibited 31862882 1 5 25 RNF208 targets Ser39 phosphorylation inducing polyubiquitination-mediated degradation, and suppressing metastasis. -Dbn1 DBN1 Actin-binding; Cytoskeletal; Motility/polarity/chemotaxis Q07266 81653 17p14 rat S142-p 452446 NGLARLSsPVLHRLR cell motility, altered; cytoskeletal reorganization 25945928 6 87 28 phospho-dephospho cycle required for proper neuroblast orientation during polarized migration along the rostral migratory stream (RMS). -Atp1a1 ATP1A1 EC 3.6.3.9; Hydrolase; Membrane protein, integral; Membrane protein, multi-pass; Transporter; Transporter, ion channel P06685 24211 2q34 rat S943-p 451649 ICKTRRNsVFQQGMK Cation_ATPase_C activity, induced; molecular association, regulation; activity, inhibited 27013656; 36377055; 9435504 9 2 0 -STAP2 STAP2 Adaptor/scaffold Q9UGK3 55620 19p13.3 human Y310-p 6155352 LPNQEENyVTPIGDG transcription, altered 12540842 1 0 2 -RASSF1 RASSF1 iso2 Tumor suppressor Q9NS23-2 11186 3p21.31 human S131-p 486364 EWETPDLsQAEIEQK activity, induced; molecular association, regulation; intracellular localization carcinogenesis, altered; signaling pathway regulation; cell growth, altered XPA(INDUCES); RASSF1 iso2(INDUCES); MST2(INDUCES) 19962312; 22389451; 25368379 6 0 0 -Gria1 GluR1 Channel, calcium; Channel, ligand-gated; Membrane protein, integral; Membrane protein, multi-pass P23818 14799 11 B1.3|11 34.51 cM mouse T858-p 3362100 NEAIRTStLPRNSGA activity, induced; activity, inhibited; phosphorylation 17689977; 24706758 5 1 0 inhibits S863 phosphorylation; inhibits channel activity; synaptic plasticity -PSMD11 PSMD11 Protease; Proteasome complex O00231 5717 17q11.2 human S14-p 468525 VEFQRAQsLLSTDRE RPN6_N activity, induced; enzymatic activity, induced 26669444; 30782827 3 47 30 Increases proteosome activity -Notch1 Notch 1 Membrane protein, integral; Motility/polarity/chemotaxis; Oncoprotein; Receptor, misc.; Transcription factor Q01705 18128 2 A3|2 18.91 cM mouse K2154-ac 18899513 KARKPSTkGLACGSK protein stabilization; ubiquitination 21499261 2 1 0 -RIGI RIGI EC 3.6.4.13; Hydrolase O95786 23586 9p21.1 human K181-ub 486286 ALEKERNkFSELWIV CARD_2 protein degradation 26471729 3 2 0 -SLC12A6 KCC3 Membrane protein, integral; Membrane protein, multi-pass; Transporter; Transporter, SLC family Q9UHW9 9990 15q14 human S96-p 10787161 IEDLSQNsITGEHSQ activity, inhibited 24043619 2 5 2 Regulates the cotransporter activity -RPS10 RPS10 Nucleolus; RNA-binding; Ribosomal; Translation P46783 6204 6p21.31 human K138-ub 486965 AVPPGADkKAEAGAG translation, altered 32324387 2 11 139 translational read-through of poly(A) mRNA sequence (KAAA) 20, ZNF598 plays a role in this process -CPEB3 CPEB3 RNA-binding Q8NE35 22849 10q23.32 human K294-sm 1877467601 NPISPLKkPFSSNVI molecular association, regulation ACTB(DISRUPTS) 32848053 1 0 0 SUMOylation of CPEB3 is a potential inhibitor for the CPEB3/F-actin interaction -Sqstm1 SQSTM1 Autophagy; Nuclear receptor co-regulator; Ubiquitin conjugating system Q64337 18412 11|11 B1.3 mouse S409-p 40253303 QMLSMGFsDEGGWLT UBA_5 protein degradation; ubiquitination autophagy, induced 25723488 3 2 0 autophagic degradation of polyQ-Huntington mutant proteins -NFAT5 NFAT5 iso2 Transcription factor O94916-2 10725 16q22.1 human K282-ac 49199203 GRNTTPCkEVDIEGT RHD_DNA_bind molecular association, regulation transcription, inhibited DNA(DISRUPTS) 26297866 1 0 0 -P2RY4 P2RY4 GPCR, family 1; Membrane protein, integral; Membrane protein, multi-pass; Receptor, GPCR P51582 5030 Xq13.1 human S333-p 10349702 PQPRTAAsSLALVSL receptor desensitization, altered; receptor internalization, altered 11114308 1 0 0 -Vcl Vinculin Cell adhesion; Cytoskeletal; Motility/polarity/chemotaxis Q64727 22330 14 A3|14 11.53 cM mouse Y822-p 450873 KSFLDSGyRILGAVA Vinculin phosphorylation apoptosis, altered; cell motility, altered 15138291 5 45 1609 regulates ERK, PXN, and FAK phosphorylation -Jak2 JAK2 EC 2.7.10.2; KINASE; Kinase, protein; Oncoprotein; Protein kinase, TK; Protein kinase, tyrosine (non-receptor) Q62120 16452 19 C1|19 23.73 cM mouse Y317-p 7603503 TEQDVQLyCDFPDII Jak1_Phl enzymatic activity, inhibited 19364823 1 1 0 -CDKN1B p27Kip1 Cell cycle regulation; Inhibitor; Oncoprotein; Protein kinase, regulatory subunit P46527 1027 12p13.1 human S83-p 451426 WQEVEKGsLPEFYYR protein conformation 15034923 2 0 0 -MYL9 MRLC1 Contractile; Motility/polarity/chemotaxis P24844 10398 20q11.23 human S20-p 1863500 KRPQRATsNVFAMFD activity, induced; molecular association, regulation; intracellular localization carcinogenesis, induced; cell motility, induced; cell adhesion, induced; cell motility, altered; cytoskeletal reorganization; cell adhesion, altered; signaling pathway regulation 10092231; 12081505; 18854160; 21336303; 22136066; 26169356; 31834925; 34532864; 35594862; 37064875 49 65 294 -RPS6KA4 MSK2 EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, AGC; Protein kinase, Ser/Thr (non-receptor) O75676 8986 11q13.1 human S360-p 447953 PRIFQGYsFVAPSIL Pkinase_C enzymatic activity, induced 10806207 1 2 11 -AKT1 Akt1 EC 2.7.11.1; KINASE; Kinase, protein; Oncoprotein; Protein kinase, AGC; Protein kinase, Ser/Thr (non-receptor) P31749 207 14q32.33 human Y315-p 448519 TFCGTPEyLAPEVLE Pkinase enzymatic activity, induced transcription, altered 15994200; 20606012 5 2 13 -RGS16 RGS16 GAP; GAP, RGS O15492 6004 1q25.3 human Y168-p 448652 TLMEKDSyPRFLKSP RGS activity, induced; protein stabilization 11602604; 12588871 2 0 0 -LSM4 LSM4 RNA-binding; Spliceosome Q9Y4Z0 25804 19p13.11 human R117-m2 12190483 GVFGGRGrGGIPGTG molecular association, regulation SMN(INDUCES) 11720283 1 1 2 -KCNA5 Kv1.5 Channel, potassium; Membrane protein, integral; Membrane protein, multi-pass P22460 3741 12p13.32 human S559-p 1269647505 VQRKVSGsRGSFCKA activity, inhibited 30279167 1 0 0 mediates HPV -CCNE1 CCNE1 Activator; Cell cycle regulation; Nuclear receptor co-regulator P24864 898 19q12 human T395-p 447676 PLPSGLLtPPQSGKK protein degradation; molecular association, regulation; ubiquitination cell cycle regulation FBXW7(INDUCES); SKP2(INDUCES) 10500095; 10652300; 11237742; 15364936; 17434132; 19561641; 8861947 15 11 0 association in vitro and in vivo; T380 of cyclin E is necessary for for ubiquination and targeting to the proteosome. -RB1 Rb Nuclear receptor co-regulator; Oncoprotein; Transcription, coactivator/corepressor; Tumor suppressor P06400 5925 13q14.2 human T821-p 447983 KISEGLPtPTKMTPR Rb_C activity, induced; acetylation; molecular association, regulation cell cycle regulation; cell growth, induced; apoptosis, inhibited; transcription, induced; cell growth, altered Elf-1(DISRUPTS); E2F1(DISRUPTS); SP1(INDUCES); Rb(INDUCES); TFDP1(DISRUPTS); HDAC5(DISRUPTS) DNA(DISRUPTS) 16360038; 21880723; 22895174; 33419772; 34158578; 36047562; 8626527; 9315635 26 40 64 -Itgb1 ITGB1 Cell adhesion; Cell surface; Membrane protein, integral; Motility/polarity/chemotaxis; Receptor, misc. P09055 16412 8|8 E2 mouse T789-p 447709 IYKSAVTtVVNPKYE Integrin_b_cyt molecular association, regulation; activity, inhibited exocytosis, induced; cell growth, induced; cell differentiation, induced; cytoskeletal reorganization; cell adhesion, altered; transcription, altered; cell adhesion, inhibited FN1(DISRUPTS); kindlin-2(DISRUPTS); SNX17(DISRUPTS) 19555977; 24719112; 34996844; 35090553; 9512507 14 3 1 The TT788-9AA mutant is defective in mediating cell attachment and does not contribute to fibronectin fibril formation. -Tjp1 ZO1 Adaptor/scaffold; Motility/polarity/chemotaxis P39447 21872 7 C|7 35.02 cM mouse Y1164-p 450401 EEQPAPAyEVHNRYR cell cycle regulation; cell motility, altered 18515860 1 13 137 -HDAC5 HDAC5 DEACETYLASE; Deacetylase; EC 3.5.1.98; Hydrolase Q9UQL6 10014 17q21.31 human S611-p 14574360 VKDEEGEsGAEEGPD molecular association, regulation; intracellular localization MEF2D(DISRUPTS); GPS2(INDUCES); HDAC3(DISRUPTS); SMRT(INDUCES); N-CoR1(INDUCES); TBL1X(INDUCES); TBL1XR1(INDUCES) 24920159 2 20 0 interactions have been defined by quantitative mass spectrometry -Hmgcr HMGCR EC 1.1.1.34; Endoplasmic reticulum; Membrane protein, integral; Membrane protein, multi-pass; Motility/polarity/chemotaxis; Oxidoreductase; Secondary Metabolites Metabolism - terpenoid backbone biosynthesis P51639 25675 2q12 rat S871-p 448568 SHMVHNRsKINLQDL enzymatic activity, inhibited 2369897 5 11 0 -NFATC1 NFAT2 DNA-binding; Transcription factor O95644 4772 18q23 human S261-p 15412721 ARSSRPAsPCNKRKY protein stabilization 28235034 2 7 16 -EPAS1 HIF2A DNA-binding; Transcription factor Q99814 2034 2p21 human K385-ac 7761201 GKGAVSEkSNFLFTK transcription, inhibited 19498162 2 1 0 -KCNJ4 HIR Channel, potassium; Membrane protein, integral; Membrane protein, multi-pass P48050 3761 22q13.1 human T53-p 450871 IFTTCVDtRWRYMLM IRK activity, inhibited 10206975 1 0 0 Phosphorylation dramatically inhibits channel activity. -AHR AHR DNA-binding; Transcription factor P35869 196 7p21.1 human S12-p 451412 SANITYAsRKRRKPV intracellular localization transcription, altered 15063792 1 0 0 Dephosphorylated AhR enters the nucleus. -NUP62 NUP62 Adaptor/scaffold; Nucleoporin P37198 23636 19q13.33 human K432-ac 1883343300 HADEEREkTYKLAEN intracellular localization cell cycle regulation; cytoskeletal reorganization 36190325 1 0 0 Acetylation-elicited remodeling of nucleoporin complex regulates Nup62 on the mitotic spindle and proper spindle orientation and segregation, and the cortical localization of LGN?NuMA -KCNH2 Kv11.1 Channel, potassium; Membrane protein, integral; Membrane protein, multi-pass; Motility/polarity/chemotaxis Q12809 3757 7q36.1 human Y475-p 3496802 LINFRTTyVNANEEV Ion_trans activity, induced 18617000 1 0 0 -HNRNPK hnRNP K RNA splicing; RNA-binding; Spliceosome P61978 3190 9q21.32 human R299-m2 476714 PPPGRGGrGGSRARN protein stabilization; phosphorylation cell motility, induced 17191129; 31110205 3 6 11 -RAMAC RAMAC RNA processing Q9BTL3 83640 15q25.2 human S36-p 3210933 YLKRPPEsPPIVEEW RAM protein degradation; ubiquitination 27452456 1 44 1 -CFLAR CFLAR Apoptosis O15519 8837 2q33.1 human S193-p 7590803 LQAAIQKsLKDPSNN ubiquitination 19343040 1 2 0 -Crtc1 TORC1 Transcription factor Q157S1 684527 16p14 rat S167-p 18255800 MTPTQAEsFTGGPQD TORC_M intracellular localization; activity, inhibited apoptosis, altered; transcription, inhibited 21220102 2 0 0 -CDT1 CDT1 DNA replication; DNA-binding; Motility/polarity/chemotaxis; Oncoprotein Q9H211 81620 16q24.3 human S491-p 21440505 GSCCTIMsPGEMEKH CDT1_C protein stabilization; molecular association, regulation; activity, inhibited RAMP(DISRUPTS) 21930785 1 2 0 -Tlr3 TLR3 Membrane protein, integral; Receptor, cytokine Q99MB1 142980 8|8 B1.1 mouse K766-ub 1877292606 AYIIHAHkDRDWVWE TIR protein degradation; ubiquitination transcription, inhibited 31076723 1 1 0 K48 linked polyubiquitylation -Ripor2 FAM65B Cytoskeletal Q80U16 193385 13|13 A3.1 mouse S46-p 4746003 NGIIRSQsFAGFSGL PL48 activity, induced autophagy, inhibited 30349076 1 30 88 inhibits cell death -GSDME DFNA5 Tumor suppressor O60443 1687 7p15.3 human T6-p 50777052 __MFAKAtRNFLREV Gasdermin protein stabilization; molecular association, regulation; intracellular localization; protein conformation; activity, inhibited apoptosis, inhibited; signaling pathway regulation DFNA5(DISRUPTS); CASP3(DISRUPTS) 30976076; 37460805 2 2 0 -GPR84 GPR84 GPCR, family 1; Membrane protein, integral; Membrane protein, multi-pass; Motility/polarity/chemotaxis; Receptor, GPCR Q9NQS5 53831 12q13.13 human T263-p 1876864002 SEPVSAAtTQTLEGD 7tm_1 receptor internalization, induced; molecular association, regulation ARR3(INDUCES); ARRB2(INDUCES) 35427647 1 1 0 -SP4 SP4 C2H2-type zinc finger protein; DNA-binding; Transcription factor Q02446 6671 7p15.3 human S770-p 17548374 VAAISQDsNPATPNV protein degradation 26049820 3 5 0 S770 phosphorylation may regulate degradation, but may be other mechanism. -Grik5 GluR KA2 Channel, ligand-gated; Membrane protein, integral; Membrane protein, multi-pass Q63273 24407 1q21 rat T976-p 27535801 PTGPRELtEHE____ molecular association, regulation PSD-95(DISRUPTS) 23288040 1 0 0 necessary for KAR-LTD; increases expression of KARs at the plasma membrane; reduced at dendritic spines; increases lateral mobility of KARs -Ptpn11 SHP-2 EC 3.1.3.48; Motility/polarity/chemotaxis; PHOSPHATASE; Protein phosphatase, tyrosine (non-receptor) P35235 19247 5|5 F mouse Y304-p 451495 PNEPVSDyINANIIM Y_phosphatase molecular association, regulation GRB2(INDUCES) 8995399 2 2 56 -EZR Ezrin Cytoskeletal; Motility/polarity/chemotaxis P15311 7430 6q25.3 human Y354-p 448105 LMLRLQDyEEKTKKA ERM_helical activity, induced; molecular association, regulation; intracellular localization cell motility, altered; cytoskeletal reorganization PIK3R1(INDUCES) 10377409; 16873375; 24385580; 9230083 14 5 259 -GLS glutaminase Amino Acid Metabolism - alanine, aspartate and glutamate; Amino Acid Metabolism - arginine and proline; EC 3.5.1.2; Energy Metabolism - nitrogen; Hydrolase; Mitochondrial; Other Amino Acids Metabolism - D-Glutamine and D-glutamate O94925 2744 2q32.2 human K158-sc 1878180001 QEKIPVHkFITALKS protein stabilization autophagy, induced 30910998 1 0 0 suppresses its Lys48-linked ubiquitination -Gata4 GATA4 Motility/polarity/chemotaxis; Transcription factor Q08369 14463 14 D1|14 33.24 cM mouse S261-p 450013 IKPQRRLsASRRVGL protein stabilization; molecular association, regulation; acetylation p300(INDUCES) 22674427 9 1 1 -NFE2L2 NRF2 DNA-binding; Transcription factor Q16236 4780 2q31.2 human K516-ac 7106317 VAAQNCRkRKLENIV bZIP_Maf molecular association, regulation transcription, induced DNA(INDUCES) 19273602 1 1 0 -Adam22 ADAM22 Cell adhesion; Membrane protein, integral; Motility/polarity/chemotaxis Q9R1V6 11496 5 A1|5 3.39 cM mouse S832-p 469108 NGRPRSNsWQGNMGG protein stabilization; molecular association, regulation endocytosis, inhibited 14-3-3 epsilon(INDUCES); AP2M1 iso2(DISRUPTS) 34910912 2 24 97 -PKD2 PKD2 Channel, cation; Membrane protein, integral; Membrane protein, multi-pass Q13563 5311 4q22.1 human S829-p 4696848 HSSRRRGsISSGVSY activity, induced cell cycle regulation; cell growth, induced; transcription, induced 23390129; 26269590 3 5 0 -HNF4A HNF4 alpha DNA-binding; Nuclear receptor; Transcription factor P41235 3172 20q13.12 human S167-p 458371 VLSRQITsPVSGING molecular association, regulation transcription, induced PC4(INDUCES) 16351573 4 5 28 -NFKB1 NFkB-p105 DNA-binding; Transcription factor P19838 4790 4q24 human K440-ub 5018600 GTMDTESkKDPEGCD molecular association, regulation; protein processing DNA(INDUCES) 10207090 1 0 0 -RGS3 RGS3 GAP; GAP, RGS P49796 5998 9q32 human S943-p 469926 SLRRRTHsEGSLLQE molecular association, regulation transcription, altered 14-3-3 zeta(INDUCES); G-alpha(q)(DISRUPTS) 11985497 1 34 54 -USP25 USP25 DEUBIQUITINASE; EC 3.4.19.12; Protease; Ubiquitin conjugating system; Ubiquitin-specific protease Q9UHP3 29761 21q21.1 human T727-p 40407603 QKLRESEtSVTTAQA ubiquitination; enzymatic activity, inhibited 25755282 1 0 0 in vitro deubiquitination assays -Jak2 JAK2 EC 2.7.10.2; KINASE; Kinase, protein; Oncoprotein; Protein kinase, TK; Protein kinase, tyrosine (non-receptor) Q62120 16452 19 C1|19 23.73 cM mouse Y813-p 451492 NSLFTPDyELLTEND molecular association, regulation SH2-B-beta(INDUCES) 15121872; 28912580 8 3 2 -PDCL PhLP G protein regulator, misc. Q13371 5082 9q33.2 human S19-p 448824 KLQYYYSsSEDEDSD molecular association, regulation G-gamma 2(INDUCES); CCTA(INDUCES) 15889144; 16717095 4 3 3 PhLP phosphorylation at S18-S20 induces association of G-gamma(2) with a G-beta(1)/PhLP complex. These PhLP phosphorylations are also required for normal G-beta/G-gamma dimer assembly.; facilitates dimerization of subunits beta and gamma of G-protein -POLI POLI DNA repair, damage; EC 2.7.7.7; Transferase Q9UNA4 11201 18q21.2 human K335-ub 50771304 SEEDSFKkCSSEVEA IMS_C protein degradation 26370087 1 1 0 -OPRK1 KOR-1 GPCR, family 1; Membrane protein, integral; Membrane protein, multi-pass; Receptor, GPCR P41145 4986 8q11.23 human S358-p 1975303 RMERQSTsRVRNTVQ ubiquitination; enzymatic activity, induced signaling pathway regulation 18212250; 23086943 2 0 1 S358 phosphorylation enhances KOR-1 ubiquitination; KOR-agonist-induced signaling for p38 MAPK/ERK1/2 activation -PPP2R5A PPP2R5A Motility/polarity/chemotaxis; Protein phosphatase, regulatory subunit Q15172 5525 1q32.3 human S28-p 459127 VDGFTRKsVRKAQRQ activity, induced; intracellular localization apoptosis, altered 18957415 2 0 8 increases mitochondrial PP2A activity -POLR2A POLR2A EC 2.7.7.48; EC 2.7.7.6; Nucleotide Metabolism - purine; Nucleotide Metabolism - pyrimidine; Transcription initiation complex; Transferase P24928 5430 17p13.1 human S1621-p 3439802 SYSPTSPsYSPTSPS RNA_pol_Rpb1_R molecular association, regulation; phosphorylation transcription, induced; transcription, altered INTS11(INDUCES); POLR1B(INDUCES) 18079403; 18079404; 19901026; 20457598; 22137580 13 2 0 transcription of small nuclear RNA genes; snRNA expression and processing, decrease in S1616 phosphorylation; phosphorylation correlated with transcription -HDAC1 HDAC1 DEACETYLASE; Deacetylase; EC 3.5.1.98; Hydrolase; Nuclear receptor co-regulator Q13547 3065 1p35.2-p35.1 human K218-ac 4219805 LRDIGAGkGKYYAVN Hist_deacetyl enzymatic activity, inhibited transcription, inhibited 16762839 1 0 0 -EIF5 EIF5 Translation; Translation initiation P55010 1983 14q32.32 human S389-p 448029 LKEAEEEsSGGEEED W2 molecular association, regulation cell cycle regulation; translation, altered eIF2-alpha(INDUCES) 16227438; 18649047 3 52 44 -Grik5 GluR KA2 Channel, ligand-gated; Membrane protein, integral; Membrane protein, multi-pass Q63273 24407 1q21 rat S892-p 19014315 LSNGKLYsAGAGGDA molecular association, regulation PSD-95(DISRUPTS) 23288040 2 1 0 necessary for KAR-LTD; increases expression of KARs at the plasma membrane; reduced at dendritic spines; increases lateral mobility of KARs -TP53 p53 Activator; DNA-binding; Motility/polarity/chemotaxis; Nuclear receptor co-regulator; Transcription factor; Tumor suppressor P04637 7157 17p13.1 human S378-p 447534 SKKGQSTsRHKKLMF activity, induced; molecular association, regulation; intracellular localization cell cycle regulation; chromatin organization, altered; transcription, induced S100B(DISRUPTS); p53(INDUCES); 14-3-3 zeta(INDUCES); 14-3-3 epsilon(INDUCES); BLM(DISRUPTS); S100A2(DISRUPTS); 14-3-3 gamma(INDUCES); WRN(DISRUPTS) DNA(INDUCES) 11585729; 12080066; 17898864; 18812399; 19819244; 19933256; 9315650; 9620776 15 2 0 S376/3787 phosphorylated peptides inhibited helicase activityin vitro. S15 phosphorylated p53 colocalized with BLM in vivo. -DNMT1 DNMT1 Amino Acid Metabolism - cysteine and methionine; Cell development/differentiation; EC 2.1.1.37; METHYLTRANSFERASE; Methyltransferase; Methyltransferase, DNA; Transcription regulation P26358 1786 19p13.2 human K739-sm 12726302 SWVGEAVkTDGKKSY enzymatic activity, induced DNA(INDUCES) 19450230 1 0 0 -EGR1 EGR1 C2H2-type zinc finger protein; DNA-binding; Transcription factor P18146 1958 5q31.2 human K272-sm 1872377900 GLGTPDQkPFQGLES phosphorylation carcinogenesis, inhibited; cell growth, inhibited; transcription, induced 19057511 1 0 0 Phosphorylation of EGR1 is necessary for EGR1 sumoylation, PTEN transcription -Rps6ka1 p90RSK EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, AGC; Protein kinase, Ser/Thr (non-receptor); Translation P18653 20111 4|4 D2.3 mouse S352-p 447989 TSRTPRDsPGIPPSA Pkinase_C enzymatic activity, induced 14726002 42 47 4 -BAP1 BAP1 DEUBIQUITINASE; EC 3.4.19.12; Protease; Tumor suppressor; Ubiquitin conjugating system; Ubiquitin-specific protease Q92560 8314 3p21.1 human S592-p 477921 SIRPIQGsQGSSSPV intracellular localization DNA repair, induced 24211834; 24347639 2 5 7 -PTPRE PTPRE EC 3.1.3.48; Membrane protein, integral; Motility/polarity/chemotaxis; PHOSPHATASE; Receptor protein phosphatase, tyrosine P23469 5791 10q26.2 human N23-ng 1871141700 LARALRGnETTADSN phosphorylation 31722979 1 0 0 mutants decrease phosphorylation -Dennd1a DENND1A GEF; GEF, Rab; Vesicle Q8K382 227801 2|2 B mouse S538-p 484448 RTLKESDsAEGDETE molecular association, regulation 14-3-3 epsilon(INDUCES) 26055712 1 10 1 -Wnk4 WNK4 EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, Other; Protein kinase, Ser/Thr (non-receptor) Q80UE6 69847 11|11 D mouse S1196-p 5879855 PGIMRRNsLSGSSTG enzymatic activity, induced 28096417 5 11 9 -MDM4 MDM4 EC 6.3.2.-; Ligase; UBIQUITIN LIGASE; Ubiquitin conjugating system; Ubiquitin ligase O15151 4194 1q32.1 human S314-p 62381100 TECKKFNsPSKRYCF zf-RanBP protein stabilization; molecular association, regulation; intracellular localization MDM2(INDUCES) 27927748 1 1 0 nuclear localization -DPYSL2 CRMP-2 Microtubule-binding; Motility/polarity/chemotaxis Q16555 1808 8p21.2 human S522-p 448082 PASSAKTsPAKQQAP molecular association, regulation; intracellular localization; phosphorylation carcinogenesis, inhibited; apoptosis, induced; cell differentiation, induced; cell motility, altered; cytoskeletal reorganization DRP1(DISRUPTS); RHOT2(DISRUPTS); RECK(DISRUPTS); TUBB3(INDUCES); MFN2(DISRUPTS) 16611631; 32019603; 32778769; 33401710; 34831395; 37174687 31 49 84 -RIPK3 RIPK3 EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, Ser/Thr (non-receptor); Protein kinase, TKL Q9Y572 11035 14q12 human T182-p 1174709701 GSGEPGGtLGYLAPE Pkinase molecular association, regulation; enzymatic activity, induced apoptosis, induced PELI1(INDUCES); MLKL(INDUCES) 29883609 1 1 0 pT182 leads to induced necroptosis. interaction of pT182 with PELI1 leads to RIPK3 ubiquitination and degradation. -NFKBIA IkB-alpha DNA-binding; Inhibitor P25963 4792 14q13.2 human Y289-p 1867984206 ESEDEESyDTESEFT signaling pathway regulation 30887112 1 0 0 NF-kB activation in BCR signaling -ECPAS ECM29 Vesicle Q5VYK3 23392 9q31.3 human S1414-p 51146701 SGLTDRNsVIQKSCA molecular association, regulation DYNC1I1(INDUCES) 26609957 1 0 0 increased retrograde transport of proteasomes in growing axons -PLAGL2 PLAGL2 C2H2-type zinc finger protein; DNA-binding Q9UPG8 5326 20q11.21 human K250-sm 483049 SQELLKIkTEPVDML intracellular localization cell growth, induced; transcription, inhibited 16207715 3 0 0 -Smc1a Smc1 DNA replication; RNA splicing Q9CU62 24061 X|X F3 mouse S957-p 448697 ISQEEGSsQGEESVS SMC_N DNA repair, induced; cell growth, induced; apoptosis, inhibited; transcription, inhibited 33524014 19 20 68 -PDCL PhLP G protein regulator, misc. Q13371 5082 9q33.2 human S18-p 448823 EKLQYYYsSSEDEDS molecular association, regulation G-gamma 2(INDUCES); CCTA(INDUCES) 15889144; 16717095 4 4 2 PhLP phosphorylation at S18-S20 induces association of G-gamma(2) with a G-beta(1)/PhLP complex. These PhLP phosphorylations are also required for normal G-beta/G-gamma dimer assembly.; facilitates dimerization of subunits beta and gamma of G-protein -NR1I2 PXR DNA-binding; Nuclear receptor O75469 8856 3q13.33 human K109-ac 54468600 CLESGMKkEMIMSDE zf-C4 molecular association, regulation; protein conformation transcription, inhibited RXRA(DISRUPTS) DNA(DISRUPTS) 26855179 1 1 0 inhibits dimerization -HIPK2 HIPK2 EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, CMGC; Protein kinase, Ser/Thr (non-receptor) Q9H2X6 28996 7q34 human S882-p 29668001 IVIPDTPsPTVSVIT protein stabilization; molecular association, regulation; protein conformation; phosphorylation; enzymatic activity, induced apoptosis, induced PIN1(INDUCES) 24145406 1 0 0 -FOXO3 FOXO3A Autophagy; DNA-binding; Oncoprotein; Transcription factor O43524 2309 6q21 human S30-p 478738 EPQSRPRsCTWPLQR transcription, induced 29445193 1 3 3 activate mitochondrial transcription in surviving cells, while the FoxO3A-S12A/S30A mutant contributed to apoptosis induction in metabolically stressed cancer cells. -KLF10 KLF10 C2H2-type zinc finger protein; DNA-binding; Transcription factor Q13118 7071 8q22.3 human S206-p 7320931 NIPCAAVsPNRSKCE protein stabilization cell cycle regulation; cell growth, inhibited SIAH1(DISRUPTS) 25728284 1 13 1 -FOXC2 FOXC2 Apoptosis; Cell development/differentiation; DNA-binding; Transcription factor Q99958 2303 16q24.1 human S281-p 3210588 NIMTLRTsPPGGELS molecular association, regulation transcription, altered DNA(INDUCES) 23878394 1 8 0 implicated in vascular remodeling in vivo -XIAP XIAP Apoptosis; EC 6.3.2.-; Ligase; UBIQUITIN LIGASE; Ubiquitin conjugating system; Ubiquitin ligase P98170 331 Xq25 human S430-p 22547400 QDESSQTsLQKEIST molecular association, regulation apoptosis, induced IRF3(INDUCES) 22072751 1 2 0 -Gsk3b GSK3B EC 2.7.11.1; EC 2.7.11.26; KINASE; Kinase, protein; Protein kinase, CMGC; Protein kinase, Ser/Thr (non-receptor) Q9WV60 56637 16|16 B3 mouse Y216-p 448569 RGEPNVSyICSRYYR Pkinase activity, induced; protein degradation; molecular association, regulation; phosphorylation; enzymatic activity, induced cell differentiation, inhibited; neural plasticity; cell growth, induced; cell differentiation, induced; transcription, inhibited; signaling pathway regulation SNCA(INDUCES) 17403689; 21445308; 21998135; 32209671; 33655459; 33829789; 36103829; 36293516 98 128 4206 -CHRNA7 nAChRA7 Channel, cation; Channel, ligand-gated; Membrane protein, integral; Membrane protein, multi-pass P36544 1139 15q13.3 human Y442-p 457467 KILEEVRyIANRFRC Neur_chan_memb activity, inhibited 16251431 1 0 1 -Sirt2 SIRT2 DEACETYLASE; Deacetylase; EC 3.5.1.- Q8VDQ8 64383 7|7 B1 mouse S372-p 482810 TTISPGKsPPPAKEA intracellular localization transcription, altered 35443760 2 21 1 -CIRBP CIRBP RNA-binding; Spliceosome; Translation Q14011 1153 19p13.3 human T43-p 801662700 VVVKDREtQRSRGFG RRM_1 intracellular localization 29432179 1 0 0 may be cause of its exclusion from the DNA-damaged regions -MAT1A MAT1A Amino Acid Metabolism - cysteine and methionine; EC 2.5.1.6; Other Amino Acids Metabolism - selenoamino acid; Transferase Q00266 4143 10q22.3 human S114-p 27996470 LVALEQQsPDIAQCV S-AdoMet_synt_N protein degradation; molecular association, regulation; intracellular localization PIN1(INDUCES) 35091576 1 3 0 -Nrf1 NRF1 DNA-binding; Transcription factor Q9WU00 18181 6 A3.3|6 12.47 cM mouse S384-p 1883500602 EATQAVAsLAEAAVA molecular association, regulation transcription, induced DNA(DISRUPTS) 37409632 1 0 0 -PTEN PTEN Carbohydrate Metabolism - inositol phosphate; EC 3.1.3.16; EC 3.1.3.48; EC 3.1.3.67; Motility/polarity/chemotaxis; Nuclear receptor co-regulator; PHOSPHATASE; Phosphatase, lipid; Tumor suppressor P60484 5728 10q23.31 human K289-ub 27490408 GPEETSEkVENGSLC PTEN_C2 intracellular localization 22103913 6 0 0 nuclear import -SLC6A4 SERT Membrane protein, integral; Membrane protein, multi-pass; Transporter P31645 6532 17q11.2 human T276-p 456508 SIWKGVKtSGKVVWV SNF activity, induced; protein conformation 16112691; 17310063; 17913921; 35258286 7 1 0 -PGR PR DNA-binding; Nuclear receptor; Transcription factor P06401 5241 11q22.1 human S162-p 450156 PATQRVLsPLMSRSG Prog_receptor transcription, induced 8662865 5 6 0 -SP7 osterix C2H2-type zinc finger protein; DNA-binding; Transcription factor Q8TDD2 121340 12q13.13 human S76-p 15334100 TSTNGLLsPAGSPPA molecular association, regulation transcription, induced AML3(INDUCES) 25122769; 27498006 4 0 0 transcriptional activity on the Cx43 promoter -TSC2 TSC2 Cell cycle regulation; GAP; GAP, misc.; Nuclear receptor co-regulator; Tumor suppressor P49815 7249 16p13.3 human S1132-p 448500 RDRVRSMsGGHGLRV activity, inhibited 27451907 5 40 20 cell survival induced -Sirt1 SIRT1 Apoptosis; DEACETYLASE; Deacetylase; EC 3.5.1.-; Nuclear receptor co-regulator Q923E4 93759 10|10 B4 mouse T522-p 6006905 HLSELPPtPLHISED molecular association, regulation; acetylation; enzymatic activity, induced cell differentiation, inhibited; apoptosis, altered p53(DISRUPTS) 20167603; 28364022 7 3 40 promotes cell survival; hepatic fatty acid oxidation -H2ax H2AX DNA repair, damage; DNA-binding; Helicase P27661 15270 9 A5.2|9 24.84 cM mouse S139-p 448841 GKKASQAsQEY____ activity, induced; molecular association, regulation DNA repair, induced; chromatin organization, altered; apoptosis, induced; transcription, induced; DNA repair, inhibited MDC1(INDUCES) 11571274; 16818236; 18158901; 31488723; 33594057; 33961949; 35393561 289 32 29 -CELF1 CELF1 Cell development/differentiation; RNA processing; RNA-binding Q92879 10658 11p11.2 human S178-p 29668006 AQTMEGCsSPMVVKF RRM_1 RNA splicing, altered 24151077 1 1 0 splicing regulation in diabetes -Gabrg2 GABRG2 Channel, chloride; Channel, ligand-gated; Membrane protein, integral; Membrane protein, multi-pass; Transporter; Transporter, ion channel P22723 14406 11 A5|11 24.8 cM mouse Y411-p 455817 LQERDEEyGYECLDG Neur_chan_memb activity, induced; receptor internalization, altered 19903874 7 0 0 spatial object recognition in mice -FSCN1 fascin Actin-binding; Cytoskeletal; Motility/polarity/chemotaxis Q16658 6624 7p22.1 human K247-ub 15388565 LKAGKATkVGKDELF Fascin cytoskeletal reorganization 27879315 1 2 1 fascin bundling activity -NLRP7 NLRP7 Apoptosis Q8WX94 199713 19q13.42 human K379-ub 1881209001 TLKLQMEkGEDPVPT protein degradation; ubiquitination 33838681 1 0 0 -Hcn1 HCN1 Membrane protein, integral; Membrane protein, multi-pass O88704 15165 13 D2.3|13 66.34 cM mouse S867-p 23112242 VTLFRQMsSGAIPPN molecular association, regulation 14-3-3 zeta(INDUCES) 35679272 2 1 3 -MDM4 MDM4 EC 6.3.2.-; Ligase; UBIQUITIN LIGASE; Ubiquitin conjugating system; Ubiquitin ligase O15151 4194 1q32.1 human S403-p 474540 DLAHSSEsQETISSM protein degradation; molecular association, regulation; ubiquitination; intracellular localization; protein conformation translation, induced USP7(DISRUPTS); MDM2(DISRUPTS); MDM2(INDUCES); p53(DISRUPTS) 15788536; 16163388; 19432880; 19808970; 22120712; 24813712; 27215386 13 2 0 interaction MDM4 with MDM2 ; lower level of MDM4 ubiquitination were observed on the triple mutant S342/367/403/A; MDM4342/A367A/403A mutant is resistant to MDM2 degradation after DNA damage, but is degradated after ARF expression. ; formation of HDMX-HDM2 heterodimer -MRPS23 MRPS23 Mitochondrial; Ribosomal; Translation Q9Y3D9 51649 17q22 human R21-m1 8093824 SRTRDLVrAGVLKEK MRP-S23 protein degradation; ubiquitination carcinogenesis, induced; cell motility, induced 33927350 1 2 2 promote degradation to a low level; promotes breast cancer metastasis, OXPHOS inhibition, mtROS production, -SUPT5H SPT5 RNA-binding; Transcription, coactivator/corepressor O00267 6829 19q13.2 human R696-m2 475965 GGSGGMSrGRGRRDN transcription, inhibited 12718890 1 1 0 inhibition of in vitro transcription assays and HIV-1 gene expression -IDH2 IDH2 Carbohydrate Metabolism - citrate (TCA) cycle; EC 1.1.1.42; Mitochondrial; Other Amino Acids Metabolism - glutathione; Oxidoreductase P48735 3418 15q26.1 human K166-ac 1194129 RLVPGWTkPITIGRH Iso_dh enzymatic activity, inhibited 32457458 2 8 12 oncometabolite 2-hydroxyglutarate (2HG) production -Eef2k EEF2K EC 2.7.11.20; KINASE; Kinase, protein; Protein kinase, Ser/Thr (non-receptor); Protein kinase, atypical; Translation P70531 25435 1q36 rat S358-p 447826 GTEEKCGsPRIRTLS enzymatic activity, inhibited 25182533 6 3 6 -SNPH syntaphilin iso2 Membrane protein, integral; Vesicle O15079-2 9751 20p13 human S56-p 23150247 LPGSRRTsAGSRRRT cell growth, induced 34087103 1 1 1 -FGF14 FGF14 Cell development/differentiation; Cytokine Q92915 2259 13q33.1 human Y153-p 1875395600 KESVFENyYVIYSSM FGF molecular association, regulation neural plasticity SCN2A(INDUCES) 34831326 1 0 0 -Ryr2 RYR2 Channel, ligand-gated; Membrane protein, integral; Membrane protein, multi-pass; Transporter; Transporter, ion channel E9Q401 20191 13 A1|13 4.38 cM mouse S2813-p 458801 ISQTSQVsIDAAHGY activity, induced; molecular association, regulation; protein conformation apoptosis, induced; signaling pathway regulation PDCD8(DISRUPTS); Calmodulin(DISRUPTS); IDH3B(DISRUPTS) 21098440; 21888910; 24498331; 24949568; 27318036; 28105734; 33755308; 33941260; 34200203 63 8 5 -CTCF CTCF C2H2-type zinc finger protein; Transcription factor; Tumor suppressor Q08705 396274 chicken S610-p 448304 RSKKEDSsDSEENAE transcription, altered; cell growth, altered 11238955 1 8 1 -Fmr1 FMR1 Nucleolus; RNA-binding; Translation P35922 14265 X A7.1|X 34.83 cM mouse S499-p 469583 NSEASNAsETESDHR FXMRP1_C_core molecular association, regulation; ubiquitination; phosphorylation neural plasticity; translation, altered; translation, induced; translation, inhibited CDH1(DISRUPTS); RCAN1(INDUCES) 14570712; 18160642; 18474609; 22099464; 22863780; 25913861; 27957526; 31118285 21 6 0 -GNAS G-alpha(s) G protein; G protein, heterotrimeric; G protein, heterotrimeric alpha G(s); Membrane protein, peripheral; Oncoprotein; Vesicle P63092 2778 20q13.32 human K28-ac 1883454301 EANKKIEkQLQKDKQ molecular association, regulation; intracellular localization carcinogenesis, induced STAT3(INDUCES) 35344606 1 1 0 mediates its cytoplasm translocation -ACTB ACTB Cytoskeletal; Motility/polarity/chemotaxis P60709 60 7p22.1 human K61-ac 461692 VGDEAQSkRGILTLK Actin molecular association, regulation CAP2(INDUCES); INF2(INDUCES) 31871199 2 7 264 acetyl-mimetic actin mutants inhibit INF2-mediated actin polimerization, CAP/Ac-actin binds INF2-DAD -Nfil3 E4BP4 DNA-binding; Transcription factor O08750 18030 13 B1|13 27.68 cM mouse S353-p 7321245 EGMQKLSsPADAIAK Vert_IL3-reg_TF transcription, inhibited 29311361 1 16 0 NK cell production inhibited -CASP2 CASP2 Apoptosis; EC 3.4.22.55; Protease P42575 835 7q34 human S164-p 241497501 STDTVEHsLDNKDGP molecular association, regulation 14-3-3 zeta(INDUCES) 28943433 1 2 0 -ILF3 NFAT90 DNA-binding; Nucleolus; RNA-binding; Transcription factor Q12906 3609 19p13.2 human S647-p 3496801 RGRGRGGsIRGRGRG intracellular localization translation, altered; transcription, altered 18097023; 20870937 2 0 0 regulates IL-2 production in T cells; required for NFAT90 export; stabilizes IL-2 mRNA -Raf1 RAF1 EC 2.7.11.1; KINASE; Kinase, protein; Oncoprotein; Protein kinase, Ser/Thr (non-receptor); Protein kinase, TKL Q99N57 110157 6 E3|6 53.62 cM mouse S43-p 447744 FGYQRRAsDDGKLTD enzymatic activity, inhibited cell growth, altered 11997508 17 23 5 -MT-CO1 COX1 EC 1.9.3.1; Energy Metabolism - oxidative phosphorylation; Membrane protein, integral; Membrane protein, multi-pass; Mitochondrial; Oxidoreductase P00395 4512 - human K481-ac 1879877106 EAFASKRkVLMVEEP apoptosis, induced 31647884 1 0 0 mutant sites were found to significantly suppressed the AAPH-evoked increase in both ROS level and apoptosis -KCNN4 KCNN4 Channel, potassium; Membrane protein, integral; Membrane protein, multi-pass O15554 3783 19q13.31 human H358-p 474525 FRQVRLKhRKLREQV CaMBD activity, induced 17157250; 18796614 3 1 0 -CSF1R CSFR EC 2.7.10.1; KINASE; Kinase, protein; Membrane protein, integral; Oncoprotein; Protein kinase, TK; Protein kinase, tyrosine (receptor) P07333 1436 5q32 human Y699-p 451527 DPEGGVDyKNIHLEK PK_Tyr_Ser-Thr molecular association, regulation PIK3CB(INDUCES) 1708091 14 6 32 -CAMK4 CAMK4 EC 2.7.11.17; KINASE; Kinase, protein; Protein kinase, CAMK; Protein kinase, Ser/Thr (non-receptor) Q16566 814 5q22.1 human S13-p 2135601 VPSCSASsCSSVTAS transcription, altered 8702940 1 0 0 -Pi4k2a PI4K2A EC 2.7.1.67; Kinase, lipid; Motility/polarity/chemotaxis Q2TBE6 84095 19 C3|19 35.74 cM mouse S9-p 2022757 DETSPLVsPERAQPP phosphorylation 25083612 2 16 0 -SLA SLAP Adaptor/scaffold Q13239 6503 8q24.22 human Y258-p 1018109 KKSISLMyGGSKRKS activity, inhibited 24284075 1 1 1 oncogenic c-Kit bypasses the normal cellular negative feedback control -DIAPH2 Diaphanous-2 iso4 Cytoskeletal; Motility/polarity/chemotaxis Q17R91 1730 Xq21.33 human S196-p 18707506 CLESLRVsLTSNPVS Drf_GBD cell cycle regulation; chromatin organization, altered; cytoskeletal reorganization 21397845 1 1 0 mutation of this site disrupts metaphase chromosome alignment -MAX MAX iso2 DNA-binding; Transcription factor P61244-2 4149 14q23.3 human S11-p 449308 NDDIEVEsDADKRAH activity, inhibited transcription, altered 8018564 5 28 0 phosphorylation-deficient mutant inhibits transcription more efficiently -SSH1 SSH1 EC 3.1.3.16; EC 3.1.3.48; PHOSPHATASE; Protein phosphatase, dual-specificity Q8WYL5 54434 12q24.11 human S402-p 10989184 MGVSRSAsTVIAYAM DSPc molecular association, regulation; enzymatic activity, inhibited cell motility, altered 21525957 2 1 7 -Grm1 mGluR1 GPCR, family 3; Membrane protein, integral; Membrane protein, multi-pass; Receptor, GPCR P23385 24414 1p13 rat T695-p 453089 GSKKKICtRKPRFMS 7tm_3 receptor desensitization, altered 10823959 1 0 0 Rapid desensitization of mGluR1 is dependent on T695 phosphorylation. -Ncor2 SMRT Nuclear receptor co-regulator; Transcription, coactivator/corepressor Q9WU42 20602 5|5 G1.1 mouse K668-sm 14988614 ILQQHKLkMEKERNA transcription, induced 20555024 1 0 0 -CDKN1B p27Kip1 Cell cycle regulation; Inhibitor; Oncoprotein; Protein kinase, regulatory subunit P46527 1027 12p13.1 human K73-sm 1873284320 NHKPLEGkYEWQEVE CDI intracellular localization carcinogenesis, induced; cell growth, induced 28882106 1 0 0 -STK4 MST1 Autophagy; EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, STE; Protein kinase, Ser/Thr (non-receptor) Q13043 6789 20q13.12 human Y433-p 463558 KIPQDGDyEFLKSWT Mst1_SARAH protein stabilization; molecular association, regulation; enzymatic activity, inhibited; phosphorylation; enzymatic activity, induced apoptosis, induced FOXO3A(INDUCES) 21715626; 30903103 3 13 110 -GSTP1 GSTP1 EC 2.5.1.18; Other Amino Acids Metabolism - glutathione; Transferase; Xenobiotic Metabolism - drug metabolism - cytochrome P450; Xenobiotic Metabolism - metabolism by cytochrome P450 P09211 2950 11q13.2 human Y199-p 463460 AFLASPEyVNLPING protein conformation; enzymatic activity, induced apoptosis, inhibited JNK1(INDUCES) 19254954; 26429914 3 2 24 -CTNNB1 CTNNB1 Actin-binding; Cell adhesion; Motility/polarity/chemotaxis; Nuclear receptor co-regulator; Oncoprotein; Transcription factor P35222 1499 3p22.1 human S552-p 472273 QDTQRRTsMGGTQQQ activity, induced; molecular association, regulation; protein stabilization; ubiquitination; intracellular localization; activity, inhibited carcinogenesis, induced; carcinogenesis, altered; cell motility, induced; apoptosis, induced; transcription, induced; transcription, altered; signaling pathway regulation; cell growth, induced; apoptosis, inhibited; cell motility, altered; cytoskeletal reorganization; transcription, inhibited 14-3-3 zeta(INDUCES); CEACAM1(INDUCES) 17287208; 20419129; 22094462; 24117889; 32195176; 33605402; 33832512; 34656562; 34657130; 34749529; 35059735; 35697802; 35715860; 35986102; 36008464; 36114575; 36181792; 36348350; 36435833; 36928362 44 64 9 -DYNLT1 DYNLT1 Microtubule-binding; Motility/polarity/chemotaxis; Motor P63172 6993 6q25.3 human S82-p 470041 AGLHTASsCFWDSST Tctex-1 molecular association, regulation cytoskeletal reorganization Rhodopsin(INDUCES); DNCLI1(DISRUPTS) 16956385; 24170091 2 0 1 S82E mutant showed significant microtubule breakage, compared to hypoxia control, release of cytochrome c agravated, ATP synthesis was lower in S82E mutant ; S82E mutant TCTEL1 is excluded, while S82A mutant protein is impaired in release, from dynein complexes; S82E and S82A mutants cause relocalization of rhodopsin -MYC Myc DNA-binding; Nucleolus; Oncoprotein; Transcription factor P01106 4609 8q24.21 human K341-sm 37036406 YPAAKRVkLDSVRVL Myc_N protein degradation; ubiquitination transcription, inhibited 25895136 2 3 0 -IRS2 IRS2 Adaptor/scaffold; Motility/polarity/chemotaxis Q9Y4H2 8660 13q34 human S577-p 483923 GLRKRTYsLTTPARQ intracellular localization 34253290 2 40 11 disassociation of IRS2 from plasma membrane to cytosol; limits PM-associated PI3K and PIP3 synthesis -CCDC6 CCDC6 Apoptosis; Cytoskeletal; Oncoprotein Q16204 8030 10q21.2 human S359-p 3197330 SPIPYTPsPSSSRPI protein degradation; molecular association, regulation cell cycle regulation FBXW7(INDUCES) 23108047; 25885523 2 7 24 -CNR1 CNR1 GPCR, family 1; Membrane protein, integral; Membrane protein, multi-pass; Receptor, GPCR P21554 1268 6q15 human S425-p 999609 TAQPLDNsMGDSDCL molecular association, regulation; protein conformation ARRB2(INDUCES) 17910957 3 4 0 -TWIST1 TWIST1 Cell development/differentiation; DNA-binding; Inhibitor; Transcription regulation Q15672 7291 7p21.1 human S123-p 14821303 RERQRTQsLNEAFAA HLH protein degradation; molecular association, regulation TWIST1(INDUCES); TCF12(DISRUPTS) 26759241; 32179550 5 1 0 induces EMT; bimolecular fluorescence complementation (BiFC) assay -TICRR TICRR Cell cycle regulation; DNA replication Q7Z2Z1 90381 15q26.1 human T969-p 20798601 LTKSVAEtPVHKQIS Treslin_N molecular association, regulation cell cycle regulation TOPBP1(INDUCES) 21700459; 25737283; 35231445 3 3 11 DNA replication induced; shortens S phase, increases replication initiation -PRKD2 PRKD2 EC 2.7.11.13; KINASE; Kinase, protein; Motility/polarity/chemotaxis; Protein kinase, CAMK; Protein kinase, Ser/Thr (non-receptor) Q9BZL6 25865 19q13.32 human S876-p 448800 QGLAERIsVL_____ enzymatic activity, induced 11062248; 12058027 5 10 1 -MAPKAPK2 MAPKAPK2 EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, CAMK; Protein kinase, Ser/Thr (non-receptor) P49137 9261 1q32.1 human T334-p 448273 QSTKVPQtPLHTSRV activity, induced; phosphorylation; enzymatic activity, induced transcription, inhibited 16278218; 23740979; 35189144; 8846784 31 14 38 -GSR GSR EC 1.8.1.7; Other Amino Acids Metabolism - glutathione; Oxidoreductase P00390 2936 8p12 human T507-p 23111522 TKADFDNtVAIHPTS Pyr_redox_dim enzymatic activity, induced carcinogenesis, induced; apoptosis, inhibited 31530934 1 1 1 ROS level maintenance -DLG4 PSD-95 Adaptor/scaffold P78352 1742 17p13.1 human T19-p 3609101 YRYQDEDtPPLEHSP protein stabilization; molecular association, regulation; protein conformation; palmitoylation neural plasticity Calmodulin(INDUCES); PIN1(INDUCES) 29118000; 32231520; 32256312 8 0 0 -Ptk2 FAK EC 2.7.10.2; KINASE; Kinase, protein; Protein kinase, TK; Protein kinase, tyrosine (non-receptor) O35346 25614 7q34 rat Y397-p 447887 SVSETDDyAEIIDEE activity, induced; molecular association, regulation; intracellular localization; enzymatic activity, induced; phosphorylation apoptosis, altered; apoptosis, inhibited; cytoskeletal reorganization; cell adhesion, altered; signaling pathway regulation; transcription, altered LYN(INDUCES); NMDAR2A(INDUCES); NMDAR2B(INDUCES) 10794722; 10848597; 12732587; 12764094; 12805241; 14627993; 15923313; 16407217; 16690621; 21357465; 21660950; 34194565 371 31 474 induces ERK signaling; focal adhesion inhibition/dissociation; integrin Rac1-NADPH oxidase signaling -Ncor1 N-CoR1 Nuclear receptor co-regulator; Transcription, coactivator/corepressor Q60974 20185 11|11 B2 mouse S2345-p 2888300 KLINKSNsRKSKSPI molecular association, regulation 14-3-3 beta(INDUCES) 17630505 1 0 0 -BRMS1 BRMS1 Tumor suppressor Q9HCU9 25855 11q13.2 human S30-p 25284673 MNGEEEEsEEERSGS protein degradation; molecular association, regulation; intracellular localization 14-3-3 epsilon(INDUCES) 26980766 1 1 1 nuclear export to cytoplasm, degradation and metastases -Add2 ADD2 Cytoskeletal; Motility/polarity/chemotaxis Q05764 24171 4q34 rat S725-p 449803 KKKEKVEs_______ intracellular localization cytoskeletal reorganization 9679146 2 0 0 -MDM4 MDM4 EC 6.3.2.-; Ligase; UBIQUITIN LIGASE; Ubiquitin conjugating system; Ubiquitin ligase O15151 4194 1q32.1 human S342-p 470031 SKLTHSLsTSDITAI protein degradation; molecular association, regulation; ubiquitination; intracellular localization USP7(DISRUPTS); MDM2(DISRUPTS); 14-3-3 theta(INDUCES); 14-3-3 gamma(INDUCES); MDM2(INDUCES); p53(DISRUPTS) 15788536; 16163388; 16943424; 19432880; 19808970; 22120712; 24190973 12 7 3 -LATS1 LATS1 EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, AGC; Protein kinase, Ser/Thr (non-receptor); Tumor suppressor O95835 9113 6q25.1 human K860-ub 1875093000 FRWTHDSkYYQSGDH Pkinase protein degradation; intracellular localization carcinogenesis, induced; cell motility, induced; cell growth, induced; transcription, induced 34593639 1 0 0 PRAMEF2-induced nuclear localization of YAP which resulted in induction of genes involved in key cancer-associated pathways. -NLRP3 NLRP3 Inhibitor Q96P20 114548 1q44 human Y861-p 59041400 SHSLTRLyVGENALG activity, inhibited 27043286 1 0 0 reduced IL-1B secretion, regulates inflammasome activation -NEK7 NEK7 EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, Other; Protein kinase, Ser/Thr (non-receptor) Q8TDX7 140609 1q31.3 human S204-p 3207291 VGTPYYMsPERIHEN Pkinase molecular association, regulation NLRP3(DISRUPTS) 31762063 1 6 1 -MPL MPL Membrane protein, integral; Receptor, cytokine P40238 4352 1p34.2 human Y591-p 454722 SSQAQMDyRRLQPSC molecular association, regulation; phosphorylation carcinogenesis, induced; cell differentiation, induced; signaling pathway regulation Syk(INDUCES); SHP-1(INDUCES) 24607955; 33384332; 36229456 5 3 15 regulates TPO mediated signaling; regulates TPO-R signaling; induces phosphorylation of Syk, ERK1/2. MAPK pathway regulation -SLC30A2 SLC30A2 Membrane protein, integral; Membrane protein, multi-pass; Transporter; Transporter, SLC family Q9BRI3 7780 1p36.11 human K4-ub 34666302 ____MEAkEKQHLLD protein degradation; ubiquitination 25016022 1 0 0 zinc accumulation and secretion -Pparg PPAR-gamma iso2 DNA-binding; Nuclear receptor; Transcription factor P37238-2 19016 6 E3|6 53.41 cM mouse S82-p 448062 AIKVEPAsPPYYSEK intracellular localization cell growth, induced; transcription, induced 21690289; 27769068 33 7 0 promoter of PFKFB4 -RPA2 RFA2 DNA replication P15927 6118 1p35.3 human S11-p 1854600 SGFESYGsSSYGGAG molecular association, regulation; intracellular localization DNA repair, induced; cell growth, altered WRN(INDUCES) 17035231; 21107010 3 0 0 upon replication blockage, WRN and RPA functionally interact ; 7xAlanine mutant has defect in down regulating DNA synthesis following UV treatment. 7xAspartate mutant did not localize to S-phase foci. -Gab1 GAB1 Adaptor/scaffold; Motility/polarity/chemotaxis Q9QYY0 14388 8|8 C2 mouse Y307-p 447944 MRHVSISyDIPPTPG molecular association, regulation; enzymatic activity, induced cell differentiation, altered; cell motility, induced; apoptosis, inhibited; signaling pathway regulation; cell growth, altered PLCG1(INDUCES) 10734310; 33786575 6 1 41 FoxO1-GAB1-pAKT signaling -CABP1 CABP1 Adaptor/scaffold; Calcium-binding; Inhibitor Q9NZU7 9478 12q24.31 human S323-p 12521706 TNGDGEIsTSELREA EF-hand_7 activity, induced 14685260 1 0 0 -ERRFI1 MIG-6 Inhibitor; Tumor suppressor Q9UJM3 54206 1p36.23 human Y395-p 454989 KVSSTHYyLLPERPP molecular association, regulation EGFR(INDUCES) 26967626; 32574989 4 9 140 -FLT3 FLT3 EC 2.7.10.1; KINASE; Kinase, protein; Membrane protein, integral; Oncoprotein; Protein kinase, TK; Protein kinase, tyrosine (receptor) P36888 2322 13q12.2 human Y599-p 448643 VDFREYEyDLKWEFP molecular association, regulation; enzymatic activity, induced; phosphorylation Src(INDUCES); SHP-2(INDUCES); Fyn(INDUCES) 11971190; 16684964; 26848862 7 0 2 -TRIP10 TRIP10 Adaptor/scaffold; Motility/polarity/chemotaxis; Nuclear receptor co-regulator Q15642 9322 19p13.3 human T225-p 1868832804 DMDERRAtRLGAGYG molecular association, regulation; intracellular localization endocytosis, induced; carcinogenesis, induced; cell motility, induced; cytoskeletal reorganization CDC42(INDUCES) 31319138 1 0 0 -SALL4 SALL4 iso3 C2H2-type zinc finger protein; Cancer Testis Antigen (CTA); DNA-binding Q9UJQ4-2 57167 20q13.2 human K316-sm 31089510 GLAPFTLkPDGTRVL protein stabilization; molecular association, regulation; intracellular localization transcription, induced Oct4(DISRUPTS) 23012367 1 0 0 -Sstr3 SSTR3 GPCR, family 1; Membrane protein, integral; Membrane protein, multi-pass; Receptor, GPCR P30936 171044 7q34 rat T357-p 456711 GSGPPEKtEEEEDEE receptor internalization, altered 9295322 2 0 0 -PPP1R3F PPP1R3F Membrane protein, integral; Protein phosphatase, regulatory subunit Q6ZSY5 89801 Xp11.23 human S18-p 22497900 LRHSAPPsPAAGEPR signaling pathway regulation 21668450 1 5 0 regulation of glycogen synthesis via R3F-PP1 signaling in astrocytoma cells -PKN1 PKN1 EC 2.7.11.13; KINASE; Kinase, protein; Protein kinase, AGC; Protein kinase, Ser/Thr (non-receptor) Q16512 5585 19p13.12 human S533-p 483281 ATGTGTFsPGASPGS enzymatic activity, induced carcinogenesis, induced; cell motility, induced; cell growth, induced 31981797 1 29 3 induces anchorage-independent cell growth -BRD4 BRD4 KINASE; Kinase, protein; Protein kinase, Ser/Thr (non-receptor); Protein kinase, atypical O60885 23476 19p13.12 human S494-p 27806303 DSSSDSSsDSDSSTD molecular association, regulation p53(INDUCES) 23317504 1 1 0 -Klf1 KLF1 C2H2-type zinc finger protein; DNA-binding; Transcription factor P46099 16596 8 41.3 cM|8 C3 mouse T23-p 457383 TLGQFLDtQEDFLKW EKLF_TAD1 activity, induced transcription, altered 9722526 1 0 0 -AATF AATF Nucleolus; RNA-binding; Transcription factor Q9NY61 26574 17q12 human T366-p 27136800 FTVYRNRtLQKWHDK AATF-Che1 molecular association, regulation; intracellular localization apoptosis, inhibited MRLC3(DISRUPTS) 22909821 1 1 0 nuclear translocation -EHMT2 EHMT2 Amino Acid Metabolism - lysine degradation; EC 2.1.1.43; METHYLTRANSFERASE; Methyltransferase; Methyltransferase, protein lysine Q96KQ7 10919 6p21.33 human S211-p 18009234 EIQHFRMsDDVHSLG molecular association, regulation; intracellular localization DNA repair, induced H3(INDUCES); RPA1(INDUCES) 28698370 1 3 0 recruitment to chromatin -INPP5D SHIP EC 3.1.3.86; Motility/polarity/chemotaxis; Phosphatase, lipid Q92835 3635 2q37.1 human S33-p 1869876001 GSFLVRAsESISRAY SH2 protein stabilization carcinogenesis, induced; cell growth, induced 31377397 1 0 0 -WASF1 WAVE1 Cytoskeletal; Motility/polarity/chemotaxis Q92558 8936 6q21 human Y125-p 457673 PIPLQETyDVCEQPP molecular association, regulation cytoskeletal reorganization Arp3(INDUCES) 16317717 1 0 0 -AKAP1 AKAP1 Adaptor/scaffold; Membrane protein, integral; Mitochondrial; RNA-binding Q92667 8165 17q22 human S151-p 465540 PLECPLSsPKGVLFS molecular association, regulation PPP1CA(DISRUPTS) 16669629 1 13 0 -ARHGEF2 ARHGEF2 GEF; GEF, Rac/Rho; Motility/polarity/chemotaxis Q92974 9181 1q22 human S172-p 460815 LGLRRILsQSTDSLN molecular association, regulation; intracellular localization cytoskeletal reorganization TUBB2B(DISRUPTS) 21513698 2 17 71 inhibits microtubule binding and stabilization, acetylation, regulates cell polarization -Nr4a2 NR4A2 DNA-binding; Nuclear receptor Q07917 54278 3q21 rat K577-sm 2407418 LQRIFYLkLEDLVPP Hormone_recep transcription, inhibited 14559918 2 0 0 -RAN RAN Cell cycle regulation; G protein; G protein, monomeric; G protein, monomeric, Ran; Motility/polarity/chemotaxis; Nuclear export; Nuclear receptor co-regulator P62826 5901 12q24.33 human S135-p 469112 DRKVKAKsIVFHRKK Ras molecular association, regulation; intracellular localization cell cycle regulation RANGAP1(DISRUPTS); RCC1(DISRUPTS) 16930555; 20805321 2 19 4 -Fzd3 FZD3 GPCR, Fz/Smo family; Membrane protein, integral; Membrane protein, multi-pass; Receptor, GPCR Q61086 14365 14 D1|14 34.09 cM mouse S577-p 18507003 DQRSKAGsVHSKVSS receptor internalization, inhibited; phosphorylation endocytosis, inhibited 21316586 1 0 0 enhances PCP signaling, regulating c-Jun phosphorylation, and affecting growth cone guidance -FPR1 FPR1 GPCR, family 1; Membrane protein, integral; Membrane protein, multi-pass; Motility/polarity/chemotaxis; Receptor, GPCR P21462 2357 19q13.41 human S332-p 450851 TEDSTQTsDTATNST molecular association, regulation; receptor desensitization, altered; receptor internalization, altered ARRB2(INDUCES) 10514456; 16622009 3 1 0 -Ubtf UBF DNA-binding; Nucleolus; Transcription factor P25977 25574 10q32.1 rat T201-p 448505 DIPEKPKtPQQLWYT HMG_box transcription, inhibited 11741541 1 11 3 -Mfn2 MFN2 Cell cycle regulation; Cytoskeletal; EC 3.6.5.-; Hydrolase; Membrane protein, integral; Membrane protein, multi-pass; Mitochondrial Q80U63 170731 4|4 E2 mouse S442-p 4746700 AEEIRRLsVLVDEYQ cell differentiation, inhibited; autophagy, induced 32165499 6 2 0 induces mitophagy -DEPTOR DEPTOR Apoptosis Q8TB45 64798 8q24.12 human S263-p 7101486 RKSTSFMsVSPSKEI protein degradation; molecular association, regulation carcinogenesis, induced; apoptosis, inhibited; signaling pathway regulation mTOR(DISRUPTS) 19446321 2 3 0 PI3K-Akt signaling -Sox11 SOX11 DNA-binding; Transcription factor Q7M6Y2 20666 12|12 A2 mouse S289-p 50800237 PPAPPALsPASSRCV protein degradation cell differentiation, induced 34431536 2 3 0 -IKBKE IKKE EC 2.7.11.10; Inhibitor; KINASE; Kinase, protein; Protein kinase, Other; Protein kinase, Ser/Thr (non-receptor) Q14164 9641 1q32.1 human Y179-p 23115344 SVYGTEEyLHPDMYE Pkinase enzymatic activity, induced cell motility, induced 27287717 1 1 4 -HCLS1 HS1 Adaptor/scaffold; Motility/polarity/chemotaxis P14317 3059 3q13.33 human Y222-p 452057 MEAPTTAyKKTTPIE activity, induced; molecular association, regulation cell motility, induced ARPC2(INDUCES) 22679023 4 4 155 HS1 phosphorylation mediates neutrophil chemotaxis and induce Rac activation -KRAS KRas iso2 G protein; G protein, monomeric; G protein, monomeric, Ras; Motility/polarity/chemotaxis; Oncoprotein P01116-2 3845 12p12.1 human K104-ac 35480405 REQIKRVkDSEDVPM Ras protein conformation; enzymatic activity, altered signaling pathway regulation; cell growth, altered 28154176 6 3 0 KRas K104Q mutant, KRas downstream signaling -RHOT1 RHOT1 EC 3.6.5.-; G protein; G protein, monomeric; G protein, monomeric, Rho; Hydrolase; Membrane protein, integral; Mitochondrial Q8IXI2 55288 17q11.2 human K194-ub 27206526 KALTRIFkISDQDND protein degradation; intracellular localization autophagy, induced 34152608 1 2 0 induces mitophagy by recruiting Parkin to mitochondria -Cxcr4 CXCR4 GPCR, family 1; Membrane protein, integral; Membrane protein, multi-pass; Receptor, GPCR P70658 12767 1 E3|1 56.43 cM mouse S353-p 7997136 SVSTESEsSSFHSS_ receptor internalization, induced; receptor desensitization, inhibited; phosphorylation 23734232 1 3 0 -Cited1 CITED1 Nuclear receptor co-regulator P97769 12705 X D|X 45.25 cM mouse S65-p 27937113 NGVPTSSsGSTSPIG CITED intracellular localization cell differentiation, induced 23529225 1 0 0 S63/64/65/67/69/73/79/80/84A mutation in CITED1 inhibits its translocation into the nucleus and osteoblasts differentiation -CDK1 CDK1 Cell cycle regulation; EC 2.7.11.22; EC 2.7.11.23; KINASE; Kinase, protein; Motility/polarity/chemotaxis; Protein kinase, CMGC; Protein kinase, Ser/Thr (non-receptor) P06493 983 10q21.2 human Y15-p 447610 EKIGEGTyGVVYKGR Pkinase molecular association, regulation; intracellular localization; enzymatic activity, inhibited; activity, inhibited; phosphorylation; enzymatic activity, altered cell cycle regulation; carcinogenesis, induced; carcinogenesis, inhibited; cell growth, inhibited; transcription, induced; cell growth, induced; apoptosis, inhibited; cytoskeletal reorganization PKM iso2(INDUCES); CDC25C(DISRUPTS) 10504341; 10770932; 11782384; 12049736; 12912980; 14767478; 14987992; 15141014; 1532335; 15735676; 15975956; 17976513; 1850698; 19276355; 19917613; 19933706; 20347419; 20360007; 21389100; 21602434; 21900495; 22850745; 24240236; 24391510; 24798733; 24910099; 25744022; 25849598; 30626720; 33796458; 33971703; 34168048; 34370741; 34570813; 34676045; 34773074; 34799355; 35056723; 35081344; 35348191; 35392228; 35738066; 36163549; 36967563; 8441405; 9268380 201 145 3902 -Hspa8 HSC70 Chaperone; Heat shock protein; Nucleolus; RNA-binding P63017 15481 9 A5.1|9 21.55 cM mouse K561-m3 3898513 EDEKLQGkINDEDKQ HSP70 protein stabilization autophagy, induced 31346037 3 5 5 stabilization of HSC70 enhances the function in chaperone-mediated autophagy, the degradation of client proteins such as transcription factors myocyte enhancer factor 2A (Mef2A) and Mef2D -BUB1B BUB1B EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, Other; Protein kinase, Ser/Thr (non-receptor); Tumor suppressor O60566 701 15q15.1 human T680-p 484623 IEDSREAtHSSGFSG molecular association, regulation cell cycle regulation PPP2R5A(INDUCES) 23079597 5 0 0 T680 is independent of attachment status and may correlate with lack of interkinetochore tension.; kinetochore-microtubule attachment -CNR1 CNR1 GPCR, family 1; Membrane protein, integral; Membrane protein, multi-pass; Receptor, GPCR P21554 1268 6q15 human S429-p 999608 LDNSMGDsDCLHKHA molecular association, regulation; protein conformation ARRB2(INDUCES) 17910957 3 3 0 -IDH2 IDH2 Carbohydrate Metabolism - citrate (TCA) cycle; EC 1.1.1.42; Mitochondrial; Other Amino Acids Metabolism - glutathione; Oxidoreductase P48735 3418 15q26.1 human K106-ac 461227 DSALATQkYSVAVKC Iso_dh enzymatic activity, inhibited 32457458 2 8 39 oncometabolite 2-hydroxyglutarate (2HG) production -PIKFYVE PIKFYVE Carbohydrate Metabolism - inositol phosphate; EC 2.7.1.150; KINASE; Kinase, lipid; Motility/polarity/chemotaxis; Protein kinase, Ser/Thr (non-receptor) Q9Y2I7 200576 2q34 human S307-p 457532 PARNRSAsITNLSLD enzymatic activity, induced 15546921 3 55 145 -MAP2K2 MEK2 EC 2.7.12.2; KINASE; Kinase, protein; Protein kinase, STE; Protein kinase, dual-specificity (non-receptor) P36507 5605 19p13.3 human S226-p 448074 LIDSMANsFVGTRSY Pkinase enzymatic activity, induced signaling pathway regulation 19106095; 21893193 56 19 201 PI3K/mTOR/p70S6K pathway -MDM2 MDM2 EC 6.3.2.-; EC 6.3.2.19; Inhibitor; Ligase; NEDDYLATION LIGASE; Neddylation Ligase; Nucleolus; Oncoprotein; UBIQUITIN LIGASE; Ubiquitin conjugating system; Ubiquitin ligase Q00987 4193 12q15 human S253-p 2132107 SVEFEVEsLDSEDYS activity, induced 12167711 2 1 0 promotes p53 degradation -FGD5 FGD5 GEF; GEF, Rac/Rho Q6ZNL6 152273 3p25.1 human Y820-p 464904 TANENDGyVDMSSFN activity, induced; enzymatic activity, induced cytoskeletal reorganization 31088862; 31267715 2 4 16 induces its activity as a GEF for Cdc42; responsible for Cdc42 activation and inhibition of thrombin-induced permeability; not necessary for recruitment of FGD5 to endothelial junctions -NUP98 NUP98 iso2 Motility/polarity/chemotaxis; Nucleoporin P52948-2 4928 11p15.4 human T653-p 478067 IAKPIPQtPESAGNK intracellular localization 21335236 1 32 18 as multiple sites (13PM) mutant -TP53 p53 Activator; DNA-binding; Motility/polarity/chemotaxis; Nuclear receptor co-regulator; Transcription factor; Tumor suppressor P04637 7157 17p13.1 human S15-p 447490 PSVEPPLsQETFSDL P53_TAD protein degradation; acetylation; protein stabilization; molecular association, regulation; activity, inhibited; phosphorylation; activity, induced; ubiquitination; intracellular localization; protein conformation cell cycle regulation; carcinogenesis, induced; apoptosis, altered; carcinogenesis, inhibited; cell growth, inhibited; apoptosis, induced; transcription, induced; signaling pathway regulation; transcription, altered; autophagy, induced; cell growth, induced; chromatin organization, altered; transcription, inhibited; cell growth, altered PKHF1(INDUCES); MDM4(DISRUPTS); BLM(DISRUPTS); S100A1(INDUCES); UBE4B(INDUCES); CBP(INDUCES); MDM2(DISRUPTS); S100A6(INDUCES); MDC1(DISRUPTS); PPP2R5C(INDUCES); TRIM24(INDUCES); NFkB-p65(INDUCES); S100B(INDUCES); DACH1(INDUCES); S100A4(INDUCES); NFkB-p100(DISRUPTS); MDM2(INDUCES); WRN(DISRUPTS); S100A2(INDUCES) DNA(INDUCES) 10606744; 10656682; 10734067; 10958792; 11030628; 11258706; 11314044; 11397945; 11707453; 11861384; 11865061; 11875057; 12071847; 12080066; 12324477; 12393500; 12427754; 12518062; 12771937; 12860987; 12955074; 14665630; 14712210; 15155458; 15159397; 15181149; 15471885; 15489892; 15775976; 16322229; 16501611; 16651424; 16714289; 16731759; 17535811; 17668048; 17891183; 17967874; 17976513; 17977830; 18056442; 18272544; 18769132; 18778462; 18794113; 19203586; 19819244; 20024960; 20353948; 20372057; 20696760; 20962272; 21317932; 21383696; 21465263; 21765463; 22030623; 22975381; 23798621; 24657168; 24820418; 25202122; 26104798; 26588988; 26673821; 26742101; 27208501; 27630139; 28153791; 31296660; 31968249; 32001619; 32061892; 32083004; 33097607; 33687951; 33745968; 33755959; 33761896; 33982778; 34103468; 34103685; 34282274; 34496248; 34523970; 34711610; 35301407; 35393546; 36007676; 36214635; 36225643; 36243702; 36541910; 36575468; 36611139; 9363941 480 12 0 -AMOTL2 AMOTL2 Cell adhesion Q9Y2J4 51421 3q22.2 human K408-ub 21128806 ANRRLASkTQEAQAG molecular association, regulation; phosphorylation cell growth, inhibited; cell motility, inhibited; transcription, inhibited YAP1(INDUCES); LATS2(INDUCES) 26598551 1 2 0 -CCNE1 CCNE1 Activator; Cell cycle regulation; Nuclear receptor co-regulator P24864 898 19q12 human S399-p 454414 GLLTPPQsGKKQSSG activity, induced; protein degradation; molecular association, regulation; intracellular localization cell cycle regulation FBXW7(INDUCES) 14536078; 15364936; 17434132; 28137908 5 2 1 decreased CCNE1 stabilization (abundance) -Ikzf1 Ikaros C2H2-type zinc finger protein; DNA-binding; Transcription factor Q03267 22778 11 A1|11 7.02 cM mouse S392-p 451352 PSNSCQDsTDTESNA activity, inhibited cell cycle regulation DNA(DISRUPTS) 15024069 1 0 2 -RIGI RIGI EC 3.6.4.13; Hydrolase O95786 23586 9p21.1 human K203-ub 1879755400 ETEDLEDkMETSDIQ protein degradation 31881323 1 0 0 -ATF3 ATF-3 Transcription factor P18847 467 1q32.3 human K42-sm 31094511 ANLTPFVkEELRFAI carcinogenesis, induced; cell growth, induced; transcription, induced; transcription, inhibited 22991139; 23591848 3 1 0 -KDM3A JMJD1A DEMETHYLASE; Demethylase; EC 1.14.11.-; Nuclear receptor co-regulator; Oxidoreductase Q9Y4C1 55818 2p11.2 human Y1114-p 35527104 ITPEDRKyGTTNLHL enzymatic activity, inhibited transcription, induced 25148682 1 0 0 -Nefh NFH Cytoskeletal P16884 24587 14q21 rat S493-p 455548 GEEAATTsPPAEEAA protein degradation; protein conformation 28882840 3 7 3 S493A aperikaryal NF aggregates; S493D NFH accumulation within axonal NFs, transport of NFH into and along axons -RUNX3 AML2 DNA-binding; Transcription factor Q13761 864 1p36.11 human K171-m2 1877292605 ATYHRAIkVTVDGPR Runt molecular association, regulation cell cycle regulation; carcinogenesis, induced; cell growth, induced; transcription, inhibited CBFB(DISRUPTS); p300(DISRUPTS) 33116296 1 1 0 -NUAK1 NuaK1 EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, CAMK; Protein kinase, Ser/Thr (non-receptor) O60285 9891 12q23.3 human S476-p 33406502 KKTQQREsGYYSSPE molecular association, regulation cell cycle regulation BRD8(INDUCES) 24785407 1 1 0 -PPP1R16B PPP1R16B Motility/polarity/chemotaxis; Protein phosphatase, regulatory subunit Q96T49 26051 20q11.23 human S69-p 17549547 KKVSFEAsVALLEAS intracellular localization cell motility, induced 34343028 1 2 3 -Mapk11 P38B EC 2.7.11.24; KINASE; Kinase, protein; Protein kinase, CMGC; Protein kinase, Ser/Thr (non-receptor) Q9WUI1 19094 15|15 E3 mouse Y323-p 477552 DEPEAEPyDESVEAK activity, induced cell growth, induced; signaling pathway regulation 21715315 1 0 0 p38 pathway activation, Induce T cell proliferation and Th Skewing, reduce autoimmunity and inflammation -MRTFA MKL1 Oncoprotein; Transcription, coactivator/corepressor Q969V6 57591 22q13.1-q13.2 human K576-sm 2407401 APLGTPVkQENSFSS transcription, inhibited 16098147 1 2 0 -GLI1 GLI1 C2H2-type zinc finger protein; Oncoprotein; Transcription factor P08151 2735 12q13.3 human S102-p 41595602 LQTVIRTsPSSLVAF activity, induced; protein degradation; molecular association, regulation; ubiquitination; intracellular localization; activity, inhibited carcinogenesis, inhibited; cell growth, inhibited; transcription, induced SUFU(DISRUPTS); BTRC(INDUCES) 26190112; 28562331; 35831023 3 1 0 -BAX BAX Apoptosis; Membrane protein, integral; Mitochondrial; Tumor suppressor Q07812 581 19q13.33 human T174-p 28847907 TPTWQTVtIFVAGVL TM intracellular localization apoptosis, induced 23907458 1 0 0 -CETN2 CETN2 Calcium-binding; Cell cycle regulation; DNA repair, damage P41208 1069 Xq28 human T118-p 28735101 KLFDDDEtGKISFKN EF-hand_7 intracellular localization 23844208 1 0 0 localization to the centrosome, capacity to form linear structures -TOB1 TOB1 Adaptor/scaffold; Cell cycle regulation P50616 10140 17q21.33 human S320-p 1869290801 YGGLNEKsFVDGLNF carcinogenesis, induced; cell motility, induced; cell growth, induced 31497236 1 1 0 -FFAR4 GPR120 iso1 GPCR, family 1; Lipid-binding; Membrane protein, integral; Membrane protein, multi-pass; Receptor, GPCR Q5NUL3-1 338557 10q23.33 human S373-p 31014806 SVKRNDLsIISG___ receptor internalization, induced; molecular association, regulation ARR3(INDUCES); ARRB1(INDUCES) 24412271; 24817122 3 1 0 -CEBPA C/EBP-alpha DNA-binding; Transcription factor P49715 1050 19q13.11 human K326-ac 56394106 SDNDRLRkRVEQLSR bZIP_2 cell differentiation, inhibited 27005833 2 0 0 -Ncoa3 SRC-3 ACETYLTRANSFERASE; Acetyltransferase; EC 2.3.1.48; Motility/polarity/chemotaxis; Nuclear receptor co-regulator; Transcription, coactivator/corepressor O09000 17979 2|2 H3 mouse S536-p 454108 SLLSTLSsPGPKLDN NCOA_u2 carcinogenesis, inhibited; cell growth, inhibited; cell differentiation, induced; transcription, inhibited; signaling pathway regulation 20534466 7 0 0 inhibits insulin/IGF1 signaling -WNK1 WNK1 EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, Other; Protein kinase, Ser/Thr (non-receptor) Q9H4A3 65125 12p13.33 human S1261-p 483845 AGRRFIVsPVPESRL molecular association, regulation; enzymatic activity, induced OSR1(DISRUPTS); STLK3(DISRUPTS) 17190791; 22032326 1 20 3 -Ctnnd1 CTNND1 Actin-binding; Adaptor/scaffold; Cell adhesion; G protein regulator, misc.; Motility/polarity/chemotaxis P30999 12388 2 D|2 49.45 cM mouse S252-p 450456 MEGYRAPsRQDVYGP molecular association, regulation cell adhesion, inhibited 26175155 6 54 205 decreased homophilic binding affinity of E-cadherin -HIF1A HIF1A Autophagy; DNA-binding; Transcription factor Q16665 3091 14q23.2 human K547-ub 12723509 FAEDTEAkNPFSTQD protein degradation 16862177 2 1 0 -MTOR mTOR Autophagy; EC 2.7.11.1; KINASE; Kinase, protein; Motility/polarity/chemotaxis; Protein kinase, Ser/Thr (non-receptor); Protein kinase, atypical P42345 2475 1p36.22 human S1261-p 458285 PMKKLHVsTINLQKA phosphorylation cell growth, induced; apoptosis, inhibited; signaling pathway regulation 19487463; 21576368; 34418433 5 29 5 -Bcl11b Bcl-11B C2H2-type zinc finger protein; Nuclear receptor co-regulator; Transcription regulation Q99PV8 58208 12 F1|12 59.1 cM mouse S318-p 4772870 PGTPPLFsPPPRHHL molecular association, regulation SENP1(INDUCES) 22700985 0 6 27 -KDM1A LSD1 DEMETHYLASE; Demethylase; EC 1.-.-.-; Nuclear receptor co-regulator; Oxidoreductase; Transcription factor O60341 23028 1p36.12 human S131-p 453104 DESLANLsEDEYYSE molecular association, regulation; ubiquitination; intracellular localization cell growth, induced RNF168(INDUCES) 25999347 1 50 262 recruited to sites of DNA damage, promotes the interaction between 53BP1 and RNF168 in chromatin, RNF168-dependent 53BP1 ubiquitination -Tigit TIGIT Cell surface; Membrane protein, integral P86176 100043314 16|16 B4 mouse Y236-p 33668513 EYFNVLSyRSLESFI molecular association, regulation SHIP(DISRUPTS) 24817116 1 0 0 -SSH1 SSH1 EC 3.1.3.16; EC 3.1.3.48; PHOSPHATASE; Protein phosphatase, dual-specificity Q8WYL5 54434 12q24.11 human S937-p 455274 SNLTRSSsSDSIHSV molecular association, regulation; intracellular localization; activity, inhibited cell motility, altered 14-3-3 beta(INDUCES) 15159416; 19567672; 21525957 3 25 13 -NDUFS4 NDUFS4 EC 1.6.5.3; EC 1.6.99.3; Energy Metabolism - oxidative phosphorylation; Mitochondrial; Oxidoreductase O43181 4724 5q11.2 human S173-p 2103602 WNKRTRVsTK_____ intracellular localization 18291624 3 1 0 -SPAG5 SPAG5 Cell cycle regulation Q96R06 10615 17q11.2 human T937-p 460416 ADEEPEStPVPLLGS intracellular localization 18055457 1 1 0 required for SPAG5 localization to the spindle apparatus during mitosis -Nos1 nNOS Amino Acid Metabolism - arginine and proline; EC 1.14.13.39; Oxidoreductase P29476 24598 12q16 rat K24-ac 2459103 SVRLFKRkVGGLGFL PDZ activity, induced 18415985 1 1 0 -Mef2d MEF2D DNA-binding; Transcription factor O89038 81518 2q34 rat S149-p 10359103 MPVTVPVsNQSSMQF HJURP_C activity, inhibited apoptosis, altered; transcription, inhibited 19801631 1 0 0 -PTS PTS Cofactor and Vitamin Metabolism - folate biosynthesis; EC 4.2.3.12; Lyase; Mitochondrial Q03393 5805 11q23.1 human S19-p 450662 AQVSRRIsFSASHRL PTPS enzymatic activity, induced 10531334 1 19 1 -NCOA2 SRC-2 Motility/polarity/chemotaxis; Nuclear receptor co-regulator; Transcription, coactivator/corepressor Q15596 10499 8q13.3 human S499-p 4728850 MSPGVAGsPRIPPSQ NCOA_u2 transcription, induced 22158970 2 19 0 -NDC80 HEC1 Cell cycle regulation O14777 10403 18p11.32 human S165-p 449867 LGYPFALsKSSMYTV Ndc80_HEC molecular association, regulation cell cycle regulation; cell growth, induced NEK2(INDUCES) 12386167; 18297113; 21832156; 24662830 6 0 0 -CAMK2B CAMK2B EC 2.7.11.17; KINASE; Kinase, protein; Protein kinase, CAMK; Protein kinase, Ser/Thr (non-receptor) Q13554 816 7p13 human T287-p 450048 SMMHRQEtVECLKKF cell motility, induced; cell adhesion, induced; cytoskeletal reorganization 35396220 32 17 109 -Myc Myc DNA-binding; Nucleolus; Oncoprotein; Transcription factor P01108 17869 15 D1|15 26.19 cM mouse T415-p 450962 VVILKKAtAYILSIQ HLH molecular association, regulation; activity, inhibited cell cycle regulation; apoptosis, inhibited; transcription, altered; transcription, inhibited; cell growth, altered MAX(DISRUPTS) 14749374; 20043278 6 0 0 mutation of this site enhances epidermal differentiation -CDK5 CDK5 Cell cycle regulation; EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, CMGC; Protein kinase, Ser/Thr (non-receptor) Q00535 1020 7q36.1 human Y15-p 448022 EKIGEGTyGTVFKAK Pkinase phosphorylation 20516069 17 47 894 induces phosphorylation of its substrate STAT3 -Kif15 KIF15 Microtubule-binding; Motor Q7TSP2 353302 8q32 rat T1142-p 9299850 EYPQSPKtPPHFQTH molecular association, regulation cell motility, inhibited MYO3B(INDUCES) 27170353 1 11 13 -DSN1 DSN1 Cell cycle regulation Q9H410 79980 20q11.23 human S77-p 3212370 QERLQSKsLHLSPQE intracellular localization 25660545 1 9 1 localization to G1 and G2 kinetochores -Glp1r GLP1R GPCR, family 2; Membrane protein, integral; Membrane protein, multi-pass; Receptor, GPCR P32301 25051 20p12 rat S431-p 451366 RLNIQRDsSMKPLKC receptor desensitization, altered 8702711 1 0 0 -HNRNPA1 hnRNP A1 Nuclear export; RNA splicing; RNA-binding; Spliceosome P09651 3178 12q13.13 human K113-sm 2894418 KIFVGGIkEDTEEHH RRM_1 sumoylation; molecular association, regulation carcinogenesis, induced LRSAM1(INDUCES) 33661764; 35579947 3 4 0 SUMOylation induced extracellular vesicle-packaged-hnRNPA1 promoting lymphangiogenesis and LN metastasis; ELNAT1 was packaged into BCa cell?secreted EVs by UBC9-induced sumoylation, EV-mediated ELNAT1?induced LN metastasis -Cpt1a CPT1A EC 2.3.1.21; Lipid Metabolism - fatty acid; Membrane protein, integral; Membrane protein, multi-pass; Mitochondrial; Transferase P32198 25757 1q42 rat S741-p 479870 FHISSKFsSPETDSH Carn_acyltransf enzymatic activity, induced 15247243 1 1 0 in vitro -PTPN11 SHP-2 EC 3.1.3.48; Motility/polarity/chemotaxis; PHOSPHATASE; Protein phosphatase, tyrosine (non-receptor) Q06124 5781 12q24.13 human Y542-p 448492 SKRKGHEyTNIKYSL molecular association, regulation; enzymatic activity, induced carcinogenesis, induced; carcinogenesis, inhibited; cell adhesion, induced; transcription, induced; transcription, altered; cell growth, induced; cell motility, altered; apoptosis, inhibited; cell adhesion, altered; cytoskeletal reorganization GRB2(NOT_REPORTED); GRB2(INDUCES); SHP-2(INDUCES) 11684012; 12531430; 16250012; 17483340; 20855525; 32076487; 34301842; 34657149; 34692535; 37330581; 8041791 38 25 442 -BUB3 BUB3 Cell cycle regulation O43684 9184 10q26.13 human S135-p 1876205008 PCNAGTFsQPEKVYT molecular association, regulation; ubiquitination; phosphorylation; enzymatic activity, induced cell cycle regulation; DNA repair, induced; carcinogenesis, inhibited; chromatin organization, altered; transcription, altered DNAPK(INDUCES); ZNF207(DISRUPTS); CDC20(INDUCES); APC(INDUCES); BUB1(INDUCES); Ku80(INDUCES); Ku70(INDUCES) 35085551 1 0 0 inhibits cyclin B1 ubiquitination, induces H2A phosphorylation -EEF1A1 EEF1A1 Nucleolus; Translation; Translation elongation P68104 1915 6q13 human K165-m2 3898709 TEPPYSQkRYEEIVK GTP_EFTU molecular association, regulation translation, altered L3MBTL iso4(INDUCES); EEF1D(DISRUPTS); eEF1B(DISRUPTS); EEF1G(DISRUPTS) 23583077; 28108655 1 7 12 -PRKD1 PRKD1 Autophagy; EC 2.7.11.13; KINASE; Kinase, protein; Motility/polarity/chemotaxis; Protein kinase, CAMK; Protein kinase, Ser/Thr (non-receptor) Q15139 5587 14q12 human S742-p 448590 GEKSFRRsVVGTPAY Pkinase molecular association, regulation; ubiquitination; enzymatic activity, inhibited; enzymatic activity, induced cell cycle regulation; cell differentiation, altered; cell growth, induced; cell motility, altered; signaling pathway regulation; transcription, altered ASK1(INDUCES); IKKB(INDUCES); PKCD(INDUCES); JNK1(INDUCES) 11948398; 15024053; 15226414; 15755722; 16891660; 18337243; 19029298; 21285358; 34010649 56 49 53 inhibits ubiquitination and induces stability of Cyclin B1; PKD-MFF signaling -Pak1 PAK1 EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, STE; Protein kinase, Ser/Thr (non-receptor) P35465 29431 1q32 rat S144-p 448170 SNSQKYMsFTDKSAE enzymatic activity, induced 11278486 24 28 138 -Tbx21 TBX21 DNA-binding; Transcription factor Q9JKD8 57765 11|11 D mouse S224-p 64227003 RLYVHPDsPNTGAHW T-box transcription, induced 28424242 1 1 0 induce IFN-gamma expression -MLH1 MLH1 Cell cycle regulation; DNA repair, damage; Tumor suppressor P40692 4292 3p22.2 human K241-ub 1878089100 EDKTLAFkMNGYISN molecular association, regulation MSH2(INDUCES); MSH6(INDUCES) 30770470 1 1 0 -Tp53 p53 Activator; DNA-binding; Motility/polarity/chemotaxis; Nuclear receptor co-regulator; Transcription factor; Tumor suppressor P02340 22059 11 B3|11 42.83 cM mouse S23-p 447529 PLSQETFsGLWKLLP P53_TAD activity, induced; molecular association, regulation; protein stabilization cell cycle regulation; apoptosis, altered; transcription, inhibited; cell growth, altered MDM2(DISRUPTS) 12356735; 15343266; 16757976; 20818388 127 2 0 -MAPT Tau iso8 ACETYLTRANSFERASE; Acetyltransferase; Cytoskeletal P10636-8 4137 17q21.31 human T205-p 447933 SSPGSPGtPGSRSRT O-GlcNAc glycosylation; molecular association, regulation; intracellular localization; protein conformation; phosphorylation cytoskeletal reorganization ubiquitin(INDUCES); Tau iso8(INDUCES) 12414518; 14761950; 15190058; 15364924; 18725412; 19451179; 20550628; 26161867; 31543505; 33952699; 35298090; 35610289; 35857446; 37488165 142 27 26 -HSF1 HSF1 DNA-binding; Transcription factor Q00613 3297 8q24.3 human T142-p 449066 DSVTKLLtDVQLMKG activity, induced; molecular association, regulation transcription, altered HSF1(INDUCES) 12659875; 35080342 4 1 0 -TBK1 TBK1 EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, Other; Protein kinase, Ser/Thr (non-receptor) Q9UHD2 29110 12q14.2 human K241-ac 56403910 MYKIITGkPSGAISG Pkinase molecular association, regulation; intracellular localization; enzymatic activity, inhibited IRF3(INDUCES) 32772249 2 2 0 recruitment of IRF3 to TBK1 -Ranbp2 RANBP2 Adaptor/scaffold; EC 5.2.1.8; EC 6.3.2.-; Ligase; Nuclear export; Nucleoporin; SUMO LIGASE; SUMO conjugating system; SUMO ligase Q9ERU9 19386 10 B4|10 29.34 cM mouse S3036-p 12667488 RKIESFGsPKGSVSR Pro_isomerase enzymatic activity, inhibited 24403063 1 27 1 -SYK Syk EC 2.7.10.2; KINASE; Kinase, protein; Protein kinase, TK; Protein kinase, tyrosine (non-receptor) P43405 6850 9q22.2 human S295-p 7445408 GIISRIKsYSFPKPG protein degradation; ubiquitination cell cycle regulation; carcinogenesis, induced 22585575 2 4 12 -UBE3A UBE3A iso2 EC 6.3.2.-; EC 6.3.2.19; Ligase; Nuclear receptor co-regulator; Transcription, coactivator/corepressor; UBIQUITIN LIGASE; Ubiquitin conjugating system; Ubiquitin ligase Q05086-2 7337 15q11.2 human Y636-p 50838700 GDSHPVLyQSLKDLL HECT protein stabilization; enzymatic activity, inhibited; protein conformation 23581475 1 1 0 oligomerization of UBE3A, Abl protects p53 from HPV-E6?E6AP complex-mediated degradation by phosphorylating E6AP -EZR Ezrin Cytoskeletal; Motility/polarity/chemotaxis P15311 7430 6q25.3 human Y146-p 448758 KEVHKSGyLSSERLI FERM_M molecular association, regulation; intracellular localization; phosphorylation carcinogenesis, induced; cell motility, induced; cell motility, altered; cytoskeletal reorganization; cell adhesion, altered; cell growth, altered EGFR(INDUCES) 15647376; 24385580; 26936397; 37328063; 9230083 16 2 2 -Etv5 ERM DNA-binding; Transcription factor Q9CXC9 104156 16|16 B1 mouse S367-p 451201 PPYQRRGsLQLWQFL transcription, induced 33219327 2 0 0 induced Cxcl5 and Cxcl12 transcription -MYOCD myocardin Cell development/differentiation; Transcription factor Q8IZQ8 93649 17p12 human K571-sm 3144811 PFLAASIkQEEAVSS transcription, induced 17101795 1 0 0 -ID2 ID2 DNA-binding; Transcription, coactivator/corepressor Q02363 3398 2p25.1 human S14-p 4706868 VRSVRKNsLSDHSLG protein stabilization cell growth, inhibited 26756672 3 16 0 -KAT7 MYST2 ACETYLTRANSFERASE; Acetyltransferase; EC 2.3.1.48; Nuclear receptor co-regulator; Transcription, coactivator/corepressor O95251 11143 17q21.33 human K338-ub 22248096 TEGSNMIkTIAFGRY zf-MYST protein degradation; acetylation cell growth, inhibited 23319590 1 1 0 H3K14 acetylation is reduced -PLD2 PLD2 EC 3.1.4.4; Lipid Metabolism - ether lipid; Lipid Metabolism - glycerophospholipid; Motility/polarity/chemotaxis; Phospholipase O14939 5338 17p13.2 human S243-p 456497 RWLVVKDsFLLYMCL enzymatic activity, induced 15979581 1 1 0 -RAB34 RAB34 G protein, monomeric; G protein, monomeric, Rab; Nucleolus Q9BZG1 83871 17q11.2 human Y247-p 455172 NSDDSNLyLTASKKK endocytosis, induced; cell motility, induced; cell adhesion, induced 29622794 1 15 107 enhances integrin beta-3 endocytosis and recycling; cell migration and invasion -DCLRE1C Artemis DNA repair, damage; Deoxyribonuclease; EC 3.1.-.- Q96SD1 64421 10p13 human S647-p 38410204 STNADSQsSSDFEVP molecular association, regulation; intracellular localization DNA repair, induced PAXIP1(INDUCES) 25512557 1 1 0 Artemis prevents end resection and promotes non-homologous end joining -SREBF1 SREBP-1 iso3 DNA-binding; Membrane protein, integral; Membrane protein, multi-pass; Transcription factor P36956-3 6720 17p11.2 human T402-p 467200 TEVEDTLtPPPSDAG transcription, induced 25353341 6 3 0 mRNA expression of central SREBP-1 target genes; Phosphorylation interferes with lipid metabolism and the secretory activity of liver cells. -NFATC2IP NFATC2IP Transcription, coactivator/corepressor Q8NCF5 84901 16p11.2 human S204-p 3206613 NSPLSPPsPRTKSRT activity, induced; molecular association, regulation carcinogenesis, induced; cell motility, induced; transcription, induced NFAT1(INDUCES) 34265397 1 41 1 -GATA3 GATA3 Transcription factor P23771 2625 10p14 human K346-ac 460637 NACGLYYkLHNINRP GATA intracellular localization cell growth, inhibited; transcription, induced 10970860 1 0 0 regulated survival after activation, regulates T-cell trafficking to secondary -TRAF3 TRAF3 UBIQUITIN LIGASE; Ubiquitin conjugating system; Ubiquitin ligase Q13114 7187 14q32.32 human K429-ub 1877126904 IRDYKRRkQEAVMGK molecular association, regulation; intracellular localization transcription, altered MAVS(INDUCES); TBK1(INDUCES) 32324863 1 1 0 TRIM24-mediated antiviral immunity, VSV-induced interaction of TRAF3 with MAVS and TBK1 -LLGL2 LLGL2 Cell cycle regulation Q6P1M3 3993 17q25.1 human S653-p 13197200 LKKSLRQsFRRMRRS intracellular localization 12725730 1 16 2 localization to cell periiphery and regulation of cell polarization -NEDD1 NEDD1 Cell cycle regulation Q8NHV4 121441 12q23.1 human S557-p 25533019 TPNPKIAsSVTAGVA molecular association, regulation cytoskeletal reorganization TUBG1(INDUCES) 22595525 1 1 0 regulates spindle assembly in mitosis; Negative effect on NEDD1 function -F11r JAM-A Cell adhesion; Membrane protein, integral O88792 16456 1 H3|1 79.43 cM mouse S285-p 467829 KVIYSQPsTRSEGEF activity, induced; protein stabilization; intracellular localization cytoskeletal reorganization 22371556; 28062807; 30723104 5 51 19 required for formation of functional tight junctions; Induce Trans-epithelial electrical resistance (TER) increase and regulates biliary epithelial barrier function -Nyap2 NYAP2 Cell development/differentiation Q8BM65 241134 1|1 C5 mouse Y277-p 455101 PEEEEPVyIEMVGNI NYAP_N molecular association, regulation PIK3R1(INDUCES) 21946561 1 1 48 localization to the neuronal plasma membrane, interaction with WAVE complex -EXO1 EXO1 EC 3.1.-.-; Hydrolase Q9UQ84 9156 1q43 human S714-p 482301 CNIKLLDsQSDQTSK protein degradation 18048416 2 4 3 -XBP1 XBP1 DNA-binding; Transcription factor P17861 7494 22q12.1|22q12 human S181-p 27523600 QQVQAQLsPLQNISP protein degradation; molecular association, regulation; intracellular localization FOXO1A(INDUCES) 23277279 1 0 0 -TCF3 E2A iso2 Cell development/differentiation; DNA-binding; Oncoprotein; Transcription factor P15923-2 6929 19p13.3 human T355-p 455166 NFSSSPStPVGSPQG molecular association, regulation transcription, induced NEUROD1(INDUCES) 12810726 3 4 25 -PML PML Nucleolus; Oncoprotein; SUMO LIGASE; SUMO conjugating system; SUMO ligase; Transcription factor; Tumor suppressor; Ubiquitin conjugating system P29590 5371 15q24.1 human S38-p 451470 EGRQPSPsPSPTERA sumoylation apoptosis, altered 19015637 2 11 0 induces sumoylation -Spred1 SPRED1 Inhibitor Q924S8 114715 2|2 E5 mouse Y420-p 18899302 IVPCMCCyVPLRMCH Sprouty cell differentiation, altered; signaling pathway regulation 21531714 1 0 0 inhibits the Ras/ERK pathway -Map3k12 DLK EC 2.7.11.25; KINASE; Kinase, protein; Protein kinase, Ser/Thr (non-receptor); Protein kinase, TKL Q60700 26404 15|15 F3 mouse K271-ub 1881852000 KIIHRDLkSPNMLIT protein degradation; enzymatic activity, inhibited 35101451 1 0 0 Fkbp8 delayed axon degeneration in mouse sciatic nerves, competition between ubiquitination and SUMOylation -LMO2 LMO2 Adaptor/scaffold; Oncoprotein P25791 4005 11p13 human K74-ac 1875199600 VGRRLYYkLGRKLCR LIM molecular association, regulation; activity, inhibited cell differentiation, inhibited; cell growth, inhibited; apoptosis, induced; transcription, inhibited LDB1(DISRUPTS) 31366618 1 0 0 inactivation of TAL-1 complex, LMO2 is deacetylated by PBEF/SIRT2 during the early stages of hematopoietic differentiation -TP53 p53 Activator; DNA-binding; Motility/polarity/chemotaxis; Nuclear receptor co-regulator; Transcription factor; Tumor suppressor P04637 7157 17p13.1 human T211-p 25535400 EYLDDRNtFRHSVVV P53 protein degradation; ubiquitination cell cycle regulation; carcinogenesis, induced; apoptosis, inhibited; transcription, inhibited 22611192 1 0 0 -TNFRSF1A TNF-R1 Membrane protein, integral; Receptor, cytokine P19438 7132 12p13.31 human Y401-p 455157 RCLREAQySMLATWR Death transcription, induced 21724995 1 0 6 -JUN Jun Oncoprotein; Transcription factor P05412 3725 1p32.1 human T95-p 1988300 ITTTPTPtQFLCPKN Jun activity, induced apoptosis, altered; transcription, altered 17920329 1 2 0 required for c-Jun mediated cell death; regulates transcription by controlling T91/T93 phosphorylation -Cacng2 Stargazin Channel, calcium; Membrane protein, integral; Membrane protein, multi-pass O88602 12300 15 E1|15 36.92 cM mouse T321-p 451273 NTANRRTtPV_____ molecular association, regulation PSD-93(DISRUPTS) 11805122 3 0 0 -RELA NFkB-p65 DNA-binding; Nuclear receptor co-regulator; Transcription factor Q04206 5970 11q13.1 human K221-me 31094533 LLCDKVQkEDIEVYF RHD_dimer molecular association, regulation transcription, induced DNA(INDUCES) 23904479 1 0 0 -PNCK CAMK1B EC 2.7.11.17; KINASE; Kinase, protein; Protein kinase, CAMK; Protein kinase, Ser/Thr (non-receptor) Q6P2M8 139728 Xq28 human T171-p 18637400 QAGNMLGtACGTPGY Pkinase enzymatic activity, inhibited; enzymatic activity, induced signaling pathway regulation 21325639; 24552815 2 0 1 ERK1/2, MAPK activity inhibited -KCNH2 Kv11.1 iso5 Channel, potassium; Membrane protein, integral; Membrane protein, multi-pass; Motility/polarity/chemotaxis Q12809_VAR_014388 3757 7q36.1 human T897-p 4839200 SFRRRTDtDTEQPGE activity, inhibited 18791070 1 1 2 reduces basal channel current amplitude -CHEK2 Chk2 EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, CAMK; Protein kinase, Ser/Thr (non-receptor); Tumor suppressor O96017 11200 22q12.1 human T378-p 981402 HSKILGEtSLMRTLC Pkinase intracellular localization 20713355 2 3 1 chromatin targeting of S372, S379, T389, singly and T383/389, T378/S379 -JAK2 JAK2 EC 2.7.10.2; KINASE; Kinase, protein; Oncoprotein; Protein kinase, TK; Protein kinase, tyrosine (non-receptor) O60674 3717 9p24.1 human K630-sm 31899103 ILVQEFVkFGSLDTY PK_Tyr_Ser-Thr molecular association, regulation; intracellular localization GH receptor(DISRUPTS) 23581279 1 0 0 translocation into the nucleus -Rem2 REM2 G protein; G protein, monomeric; G protein, monomeric, RGK Q8VEL9 140743 14|14 C2 mouse S332-p 1211204 AKFFKQRsRSCHDLS molecular association, regulation; intracellular localization 14-3-3 beta(DISRUPTS) 17605760 1 0 0 -MZF1 MZF-1 C2H2-type zinc finger protein; DNA-binding; Transcription factor P28698 7593 19q13.43 human S453-p 1868832802 GQSFRQRsNLLQHQR zf-C2H2 carcinogenesis, altered 31301870 1 0 0 alters cancer cell stemness -STING1 STING Apoptosis; Endoplasmic reticulum; Membrane protein, integral; Membrane protein, multi-pass; Mitochondrial Q86WV6 340061 5q31.2 human K338-ub 964547960 RHLRQEEkEEVTVGS protein degradation 35871231 1 1 0 UFL1 reduces STING ubiquitination -PPP1R13L PPP1R13L Apoptosis; Phosphatase, regulatory subunit; Transcription, coactivator/corepressor Q8WUF5 10848 19q13.32 human S84-p 5197296 EPFGSRGsPRKAATD molecular association, regulation; intracellular localization; protein conformation cell growth, inhibited p53(INDUCES); PPP1R13L(DISRUPTS) 23623661; 30105797 2 6 2 miR-129 inhibits phosphorylation, blocks nuclear localization and inhibits cell proliferation, p53 and TAp63 levels increased, inhibiting proliferation of Burkitt lymphoma cells; prevents N- and C-terminal self interaction, enhances binding to p53 -Vangl2 VANGL2 Adaptor/scaffold; Membrane protein, integral; Membrane protein, multi-pass Q91ZD4 93840 1 H3|1 79.54 cM mouse S82-p 18460400 VTGTSEHsISHDDLT Strabismus activity, induced; protein stabilization 21316585 1 1 0 -RRN3 TIF1A Nucleolus; Transcription initiation complex Q9NYV6 54700 16p13.11 human T200-p 455599 IARYVPStPWFLMPI RRN3 molecular association, regulation; intracellular localization; activity, inhibited transcription, inhibited TAF1B(DISRUPTS); POLR1B(DISRUPTS) 15805466 1 0 0 -Clock CLOCK ACETYLTRANSFERASE; Acetyltransferase; DNA-binding; EC 2.3.1.48; Transcription factor O08785 12753 5 C3.3|5 40.63 cM mouse S38-p 3927522 KDKAKRVsRNKSEKK HLH protein degradation; intracellular localization transcription, inhibited DNA(DISRUPTS) 19414601 1 1 0 inhibits transcription -RUNX1 AML1 DNA-binding; Oncoprotein; Transcription factor Q01196 861 21q22.12 human K167-ub 95155311 ATYHRAIkITVDGPR Runt protein degradation; intracellular localization carcinogenesis, inhibited; cell growth, inhibited; transcription, inhibited 28536267 1 1 0 -ZNF282 ZNF282 C2H2-type zinc finger protein Q9UDV7 8427 7q36.1 human K369-sm 31094512 HDILSWIkQEEQPYP molecular association, regulation carcinogenesis, induced; transcription, induced CALCOCO1(INDUCES); ER-alpha(INDUCES) 22986521 1 1 0 -RRM2 RRM2 EC 1.17.4.1; Nucleotide Metabolism - purine; Nucleotide Metabolism - pyrimidine; Other Amino Acids Metabolism - glutathione; Oxidoreductase P31350 6241 2p25.1 human K95-ac 1878237800 HDIWQMYkKAEASFW molecular association, regulation cell cycle regulation; cell growth, inhibited RRM2(INDUCES) 31324785 1 1 0 K95 disrupts its homodimerization, RRM2 is deacetylated following DNA damage -MCM4 MCM4 DNA replication; EC 3.6.4.12 P33991 4173 8q11.21 human K216-m1 58123003 NVNCEHIkSFDKNLY MCM_N molecular association, regulation L3MBTL iso4(INDUCES) 23583077 0 1 0 -CTNND1 CTNND1 Actin-binding; Adaptor/scaffold; Cell adhesion; G protein regulator, misc.; Motility/polarity/chemotaxis O60716 1500 11q12.1 human S268-p 450453 PQVRVGGsSVDLHRF activity, induced; protein stabilization; molecular association, regulation carcinogenesis, induced; endocytosis, induced; cell motility, induced; transcription, induced; cell adhesion, inhibited CDH2(DISRUPTS); LRP5(DISRUPTS); LRP6(DISRUPTS) 24412065; 32589661 12 73 56 -GCK GK Carbohydrate Metabolism - amino sugar and nucleotide sugar; Carbohydrate Metabolism - galactose; Carbohydrate Metabolism - glycolysis and gluconeogenesis; Carbohydrate Metabolism - starch and sucrose; EC 2.7.1.2; Kinase, other; Mitochondrial P35557 2645 7p13 human K414-sm 27581520 GVDGSVYkLHPSFKE Hexokinase_2 protein stabilization; enzymatic activity, induced 23297408 1 1 0 -CERS5 LASS5 DNA-binding; EC 2.3.1.24; Membrane protein, integral; Membrane protein, multi-pass; Transferase Q8N5B7 91012 12q13.12 human S355-p 18260885 DRSDVESsSEEEDVT enzymatic activity, induced 26887952 1 6 0 -Csf3r GCSFR Membrane protein, integral; Receptor, cytokine P40223 12986 4 D2.2|4 59.77 cM mouse Y728-p 451101 LPALVQAyVLQGDPR activity, induced; molecular association, regulation cell differentiation, altered; transcription, induced; signaling pathway regulation 29572350; 30679703; 7489718 4 0 0 Receptors mutant for Y728 or Y753 could neither transduce growth-inhibitory signals nor induce the neutrophil-specific myeloperoxidase (MPO) gene. A Y728 mutant did not induce morphological changes in cells.; STAT3 activation; regulates ERK1/2 pathway -TRAF3 TRAF3 UBIQUITIN LIGASE; Ubiquitin conjugating system; Ubiquitin ligase Q13114 7187 14q32.32 human S9-p 5274284 ESSKKMDsPGALQTN cell growth, induced; apoptosis, inhibited; transcription, induced; signaling pathway regulation 34255829 0 9 1 induces NIK stabilization and NF-kB signaling -TRPM8 TRPM8 Channel, cation; Membrane protein, integral; Membrane protein, multi-pass Q7Z2W7 79054 2q37.1 human K423-ub 1881122800 FSTSEQDkDNWNGQL ubiquitination; intracellular localization 33037615 1 0 0 reduces TRPM8 on cell surface, and reduces channel currents -SLCO1B1 SLCO1B1 Membrane protein, integral; Membrane protein, multi-pass; Transporter; Transporter, SLC family Q9Y6L6 10599 12p12.1 human Y645-p 13831749 VLYIILIyAMKKKYQ TM activity, induced 33664059 1 2 0 -VIL1 Villin Actin-binding; Motility/polarity/chemotaxis P09327 7429 2q35 human Y46-p 469582 SFFDGDCyIILAIHK Gelsolin cytoskeletal reorganization 12269817 2 0 1 -SSB SSB Transcription initiation complex P05455 6741 2q31.1 human K200-sm 55544702 NEERKQNkVEAKLRA molecular association, regulation RNA(INDUCES) 27224031 1 0 0 No difference in CK2-dependent SSB phosphorylation at S366 in K41R/200R mutant and WT -ADRB2 ADRB2 GPCR, family 1; Membrane protein, integral; Membrane protein, multi-pass; Receptor, GPCR P07550 154 5q32 human Y308-p 33638000 NLIRKEVyILLNWIG 7tm_1; TM signaling pathway regulation 24831005 1 0 0 induces Gs-protein-biased signaling of ADRB2 adreoceptor -kif2c KIF2C Cancer Testis Antigen (CTA); Microtubule-binding; Motility/polarity/chemotaxis; Motor Q91636 380006 frog T95-p 451107 SQNHKRKtISKIPAP molecular association, regulation; intracellular localization cytoskeletal reorganization DNA(DISRUPTS) 17567953 5 4 3 -GRIN2B NMDAR2B Channel, calcium; Channel, ligand-gated; Membrane protein, integral; Membrane protein, multi-pass Q13224 2904 12p13.1 human Y1474-p 448167 GSSNGHVyEKLSSIE NMDAR2_C carcinogenesis, induced; cell motility, induced 36139568 42 1 104 -Ahcyl1 AHCYL1 Amino Acid Metabolism - cysteine and methionine; EC 3.3.1.1; Hydrolase; Other Amino Acids Metabolism - selenoamino acid Q80SW1 229709 3 F2.3|3 46.83 cM mouse S84-p 456615 SAASYTDsSDDEVSP molecular association, regulation PIP5K1A(INDUCES) 26509711 1 3 4 -BDKRB2 BKR2 GPCR, family 1; Membrane protein, integral; Membrane protein, multi-pass; Receptor, GPCR P30411 624 14q32.2 human S373-p 447664 SMGTLRTsISVERQI receptor desensitization, altered 11517230 2 2 0 -HSPA5 GRP78 Chaperone; Heat shock protein; KINASE P11021 3309 9q33.3 human K122-ac 3692107 LPFKVVEkKTKPYIQ HSP70 molecular association, regulation; phosphorylation apoptosis, induced; signaling pathway regulation PERK(DISRUPTS) 20371724 1 2 1 induces phosphorylation of elf2a and activation of eIf2a-ATF4-CHOP pathway -MYBL2 B-Myb DNA-binding; Motility/polarity/chemotaxis; Transcription factor P10244 4605 20q13.12 human T515-p 450110 QKYSMDNtPHTPTPF Cmyb_C molecular association, regulation; protein conformation transcription, induced DNA(INDUCES) 35926712 2 1 0 -Blk BLK EC 2.7.10.2; KINASE; Kinase, protein; Protein kinase, TK; Protein kinase, tyrosine (non-receptor) P16277 12143 14 D1|14 33.25 cM mouse Y495-p 447607 YTATEGQyELQP___ protein stabilization; enzymatic activity, inhibited cell growth, altered 10449731; 9636152 2 1 19 Constitutively active mutant developed lymphomas. Tyrosine phosphorylated proteins such as PLC-gamma and PI3K, were seen in tumors. -TRIM24 TRIM24 EC 2.3.2.27; KINASE; Kinase, protein; Nuclear receptor co-regulator; Protein kinase, atypical; Transcription, coactivator/corepressor; Tumor suppressor; UBIQUITIN LIGASE; Ubiquitin conjugating system; Ubiquitin ligase O15164 8805 7q33-q34 human S808-p 3174917 KSEWLDPsQKSPLHV molecular association, regulation; phosphorylation DNA repair, induced MRE11A(INDUCES) DNA(INDUCES) 36550358 1 14 0 induces H2AX phosphorylation -RCC1 RCC1 Cell cycle regulation; GEF; GEF, Ras P18754 1104 1p35.3 human S20-p 2850003 PADAIPKsKKVKVSH molecular association, regulation KPNA4(DISRUPTS) 18568422 1 1 0 -CLASP2 CLASP2 Cytoskeletal; Motility/polarity/chemotaxis O75122 23122 3p22.3 human S541-p 24976300 RESSRDTsPVRSFQP cytoskeletal reorganization 22467876 2 5 0 -MOB1B MOB1B Activator; Protein kinase, regulatory subunit Q7L9L4 92597 4q13.3 human T12-p 3545000 FGSRSSKtFKPKKNI molecular association, regulation; phosphorylation cell cycle regulation; cell growth, altered NDR1(INDUCES); NDR2(INDUCES); LATS1(INDUCES); LATS2(INDUCES) 18328708; 19919647 3 1 3 -NR4A1 Nur77 Apoptosis; DNA-binding; Nuclear receptor P22736 3164 12q13.13 human T55-p 41583609 TALPSFStFMDGYTG cell motility, induced; cell growth, induced; cytoskeletal reorganization 26155943 1 0 0 required for increase in cell growth, cell motility, monolayer permeability, and formation of actin stress fibers. -LHX3 LHX3 DNA-binding; Transcription factor Q9UBR4 8022 9q34.3 human T63-p 455294 LKCSDCHtPLAERCF LIM activity, induced transcription, induced 15517599 1 0 0 no change in binding to DNA or to certain proteins (NLI, PIT1, or MRG1) -RPS6KB1 p70S6K EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, AGC; Protein kinase, Ser/Thr (non-receptor); Translation P23443 6198 17q23.1 human S427-p 450014 ESVKEKFsFEPKIRS enzymatic activity, induced 7489717; 7545671 5 13 0 -Msi1 Musashi-1 RNA-binding Q61474 17690 5|5 F mouse S337-p 40638600 SSYISAAsPAPSTGF cell differentiation, induced; translation, induced 25888190 1 0 0 -Ikbkb IKKB EC 2.7.11.10; KINASE; Kinase, protein; Protein kinase, Other; Protein kinase, Ser/Thr (non-receptor) O88351 16150 8|8 A2 mouse S692-p 5735033 GQLMSQPsSACDSLP molecular association, regulation; phosphorylation PPP2R3C(INDUCES) 20925653 1 0 0 interaction with PPP2R3C (aka G4-1) downregulates IKK-beta activity; S181 phosphorylation increased in S679/682/689/692/697/701/705A mutant -Notch1 Notch 1 Membrane protein, integral; Motility/polarity/chemotaxis; Oncoprotein; Receptor, misc.; Transcription factor Q01705 18128 2 A3|2 18.91 cM mouse K2150-ac 18899502 TQGKKARkPSTKGLA protein stabilization; ubiquitination 21499261 2 1 0 -Bcar1 P130Cas Adaptor/scaffold; Motility/polarity/chemotaxis Q63767 25414 19q12 rat Y764-p 448400 GWMEDYDyVHLQGKE CAS_C molecular association, regulation Fyn(INDUCES) 9360983 2 3 23 -Bag3 BAG3 Apoptosis; Chaperone Q9JLV1 29810 7|7 F3 mouse S297-p 467532 GTPVHCPsPIRVHTV protein degradation neural plasticity 31955914 2 40 27 -POU2AF1 POU2AF1 Oncoprotein; Transcription, coactivator/corepressor Q16633 5450 11q23.1 human S184-p 10239701 FPWPQPLsTLPTSTL PD-C2-AF1 transcription, induced 9211847 1 0 0 -Mtss1 MTSS1 Adaptor/scaffold; Motility/polarity/chemotaxis; Tumor suppressor Q8R1S4 211401 15|15 D1 mouse Y398-p 473757 LPDYAHYyTIGPGMF cytoskeletal reorganization 17224454 1 0 3 -Bik BIK Apoptosis; Membrane protein, integral; Mitochondrial O70337 12124 15|15 E1 mouse K33-ub 25171000 ASETPSMkEPVRDVD bcl-2I13 protein degradation 22388352 1 0 0 -TP53 p53 Activator; DNA-binding; Motility/polarity/chemotaxis; Nuclear receptor co-regulator; Transcription factor; Tumor suppressor P04637 7157 17p13.1 human K292-ub 3931323 EEENLRKkGEPHHEL protein degradation; molecular association, regulation cell cycle regulation; cell growth, induced; apoptosis, inhibited; transcription, altered DNA(INDUCES) 19536131; 28362432; 33568778 3 2 5 differential transcription-activation or inhibition at specific promoters -RALBP1 RALBP1 GAP; GAP, Rac/Rho Q15311 10928 18p11.22 human T297-p 3136101 ACGRTTEtEKVQEFQ RhoGAP activity, induced; protein conformation 16087181 1 0 0 -DUSP1 DUSP1 EC 3.1.3.16; EC 3.1.3.48; Motility/polarity/chemotaxis; PHOSPHATASE; Protein phosphatase, dual-specificity P28562 1843 5q35.1 human S296-p 457717 KQRRSIIsPNFSFMG DSPc protein degradation; molecular association, regulation SKP2(INDUCES) 16286470 1 0 0 MKP-1 is a substrate for Skp2 ligase -RYR2 RYR2 Channel, ligand-gated; Membrane protein, integral; Membrane protein, multi-pass; Transporter; Transporter, ion channel Q92736 6262 1q43 human S2808-p 448848 YNRTRRIsQTSQVSV activity, induced 30571258; 35885069 57 5 3 -DBNL DBNL Actin-binding; Motility/polarity/chemotaxis Q9UJU6 28988 7p13 human T291-p 476604 PFLQKQLtQPETHFG molecular association, regulation signaling pathway regulation 14-3-3 beta(INDUCES); 14-3-3 theta(INDUCES); HPK1(INDUCES) 21725060; 36639542 2 43 58 inhibits the MAP4K1/JNK/GPX4 cell death pathway; mutation of this site prevents 14-3-3 binding (pan-14-3-3 antibody) -IFI16 IFI16 Transcription factor Q16666 3428 1q23.1 human K99-ac 35700306 PALSRKRkKEVDATS intracellular localization 22691496 1 1 0 -CDK5R1 CDK5R1 Protein kinase, regulatory subunit Q15078 8851 17q11.2 human Y234-p 900975701 LTCLYLSySYMGNEI CDK5_activator cell adhesion, inhibited PKCD(INDUCES) 29511352 1 0 0 -MAGEA11 MAGE-A11 Cancer Testis Antigen (CTA); Transcription, coactivator/corepressor P43364 4110 Xq28 human S174-p 2028416 ESPSPPQsPQEESFS MAGE_N molecular association, regulation transcription, induced AR(INDUCES) 19828458 2 0 0 stimulates MAGE-A11 interaction with AR and increases its transcriptional activity -Stat3 STAT3 DNA-binding; Motility/polarity/chemotaxis; Nuclear receptor co-regulator; Transcription factor P52631 25125 10q31 rat S727-p 448191 NTIDLPMsPRTLDSL activity, induced; molecular association, regulation; intracellular localization cell differentiation, altered; apoptosis, altered; transcription, induced; transcription, altered SP1(INDUCES) DNA(NOT_REPORTED) 11922392; 15860735; 16048438; 16611639; 19109898; 19427337 227 57 67 -MYL12A MRLC3 Contractile P19105 10627 18p11.31 human T18-p 7382101 KKRPQRAtSNVFAMF protein conformation; enzymatic activity, induced cell cycle regulation; exocytosis, induced; cytoskeletal reorganization 10944522; 15069078; 15753305; 8530442 10 48 239 -TFAP2A AP-2 alpha DNA-binding; Transcription factor P05549 7020 6p24.3 human S429-p 20797701 TDNNAKSsDKEEKHR protein stabilization transcription, induced 21777522 1 0 0 induces AP-2 alpha transcription -BARD1 BARD1 EC 6.3.2.-; EC 6.3.2.19; Ligase; UBIQUITIN LIGASE; Ubiquitin conjugating system; Ubiquitin ligase Q99728 580 2q35 human T734-p 465471 DSDQRFCtQYIIYED RNA stability, altered 16651405 1 0 1 inhibits mRNA processing -MAP3K5 ASK1 EC 2.7.11.25; KINASE; Kinase, protein; Protein kinase, STE; Protein kinase, Ser/Thr (non-receptor) Q99683 4217 6q23.3 human S966-p 447736 NEYLRSIsLPVPVLV molecular association, regulation; enzymatic activity, inhibited; activity, inhibited apoptosis, altered; apoptosis, induced; apoptosis, inhibited; signaling pathway regulation; transcription, altered 14-3-3 beta(INDUCES); 14-3-3 zeta(INDUCES); TXN(INDUCES); 14-3-3 gamma(INDUCES); AIP1(DISRUPTS) 10411906; 14688258; 15094778; 17671211; 18794113; 19004820; 19920149; 24985705; 27514745 17 4 1 -MAN1A1 MAN1A1 Calcium-binding; EC 3.2.1.113; Endoplasmic reticulum; Glycan Metabolism - N-glycan biosynthesis; Hydrolase; Membrane protein, integral P33908 4121 6q22.31 human S12-p 15411997 GLLPLFSsPAGGVLG O-GlcNAc glycosylation; molecular association, regulation; enzymatic activity, inhibited MGAT1(DISRUPTS) 36417860 1 3 1 inhibits glycosylation -ZBTB7B ZBTB7B C2H2-type zinc finger protein O15156 51043 1q21.3 human K360-ac 31077503 KIIHGAGkLPRHMRT protein stabilization transcription, inhibited 23609452 1 0 0 increased production of IFN-gamma -IFNLR1 IL28RA Membrane protein, integral Q8IU57 163702 1p36.11 human K319-ub 1883375201 ATQQTRWkKDLAEDE protein degradation 36379255 1 0 0 -SMARCA4 SMARCA4 Cell cycle regulation; EC 3.6.1.-; EC 3.6.4.-; Helicase; Nuclear receptor co-regulator; Transcription, coactivator/corepressor; Tumor suppressor P51532 6597 19p13.2 human K1029-ac 1878219603 SEKDKKGkGGTKTLM DNA repair, induced; chromatin organization, altered 31291457 1 1 0 recruitment of SIRT1 is required for clearing nucleosomes and promoting HR at DNA DSB sites -GRIN2B NMDAR2B Channel, calcium; Channel, ligand-gated; Membrane protein, integral; Membrane protein, multi-pass Q13224 2904 12p13.1 human Y1252-p 448165 CKKAGNLyDISEDNS NMDAR2_C carcinogenesis, induced; cell motility, induced 36139568 3 0 7 -Gsc GSC DNA-binding; Transcription factor Q02591 14836 12 E|12 54.32 cM mouse K214-sm 2887206 WFKNRRAkWRRQKRS Homeodomain transcription, inhibited 18336814 1 0 0 SUMO modification inhibition is promoter specific -MST1R Ron EC 2.7.10.1; KINASE; Kinase, protein; Membrane protein, integral; Protein kinase, TK; Protein kinase, tyrosine (receptor) Q04912 4486 3p21.31 human Y1239-p 457984 DILDREYySVQQHRH PK_Tyr_Ser-Thr phosphorylation; enzymatic activity, induced cell cycle regulation; carcinogenesis, inhibited; cell growth, inhibited 24739671; 35569509 8 6 121 -TIAM1 TIAM1 GEF; GEF, Rac/Rho; Motility/polarity/chemotaxis; Oncoprotein Q13009 7074 21q22.11 human S231-p 468938 STCQRANsLGDLYAQ protein stabilization; molecular association, regulation 14-3-3 beta(INDUCES) 25746002 2 43 6 -BLVRA BVR Cofactor and Vitamin Metabolism - porphyrin and chlorophyll; EC 1.3.1.24; KINASE; Kinase, protein; Oxidoreductase; Protein kinase, Ser/Thr (non-receptor) P53004 644 7p13 human S21-p 25526801 VGVGRAGsVRMRDLR GFO_IDH_MocA enzymatic activity, induced 22584576 1 1 0 -Camkv VACAMKL KINASE; Kinase, protein; Protein kinase, CAMK; Protein kinase, Ser/Thr (non-receptor) Q3UHL1 235604 9|9 F1 mouse T345-p 60179300 QSASDAAtPGAAGGA activity, inhibited 27796283 1 1 0 dendritic spine maintenance -Lcp1 L-plastin Actin-binding; Motility/polarity/chemotaxis Q61233 18826 14 D3|14 39.63 cM mouse T89-p 3851696 KSTEVAKtFRKAINK intracellular localization cell motility, induced; cytoskeletal reorganization 27465533 1 0 12 lamellipodial formation -SLC12A2 NKCC1 Membrane protein, integral; Membrane protein, multi-pass; Transporter; Transporter, SLC family P55011 6558 5q23.3 human T217-p 455546 LRTFGHNtMDAVPRI AA_permease_N activity, induced 12145304; 12145305 9 22 33 -H3C1 H3 DNA-binding P68431 8350 6p22.2 human R17-me 2584300 STGGKAPrKQLATKA Histone transcription, induced 11747826; 15345777; 16497732 5 0 0 -NDE1 NUDE1 iso1 Cell cycle regulation; Cytoskeletal; Microtubule-binding Q9NXR1-1 54820 16p13.11 human S282-p 469633 RNLVYDQsPNRTGGP NUDE_C molecular association, regulation; intracellular localization ZNF365(DISRUPTS) 16682949 1 32 8 -Ksr1 KSR KINASE; Kinase, protein; Protein kinase, Ser/Thr (non-receptor); Protein kinase, TKL Q61097 16706 11 B5|11 46.74 cM mouse S550-p 4729130 SRKASQTsVYLQEWD phosphorylation 23993095 1 0 0 induces phosphorylation of ERK -KAT8 MYST1 ACETYLTRANSFERASE; Acetyltransferase; EC 2.3.1.48 Q9H7Z6 84148 16p11.2 human K274-ac 479461 AKLFLDHkTLYFDVE MOZ_SAS protein stabilization; molecular association, regulation; acetylation; protein conformation; enzymatic activity, induced transcription, inhibited DNA(DISRUPTS) 21502975; 22020126; 27382063 4 1 9 inhibits H4 acetylation -RACGAP1 MgcRacGAP GAP; GAP, Rac/Rho Q9H0H5 29127 12q13.12 human S387-p 449096 ETGLYRIsGCDRTVK RhoGAP activity, induced cell cycle regulation; cell growth, altered 12689593; 19555392 2 0 0 regulates cytokinesis; overexpression of the S387D mutant enhances the colony-forming ability of the v-Src-transformed cells -GGA1 GGA1 Adaptor/scaffold; Vesicle Q9UJY5 26088 22q13.1 human T270-p 2907511 LFRLASDtEDNDEAL GAT intracellular localization 14690499 1 3 12 -SHCBP1 SHCBP1 Adaptor/scaffold Q8NEM2 79801 16q11.2 human S634-p 3206817 QIKKKRLsELGITQA molecular association, regulation; intracellular localization cell cycle regulation MgcRacGAP(DISRUPTS) 23704356 1 9 0 inactivation of Rac1 byMgcRacGap to induce cytokinetic furrow ingression -SLC12A2 NKCC1 Membrane protein, integral; Membrane protein, multi-pass; Transporter; Transporter, SLC family P55011 6558 5q23.3 human T207-p 467236 YYDTHTNtYYLRTFG AA_permease_N activity, induced; enzymatic activity, induced 16669787; 20442269; 22032326 12 1 0 -Jun Jun Oncoprotein; Transcription factor P05627 16476 4 C5|4 43.34 cM mouse S73-p 447943 VGLLKLAsPELERLI Jun activity, induced; sumoylation; molecular association, regulation; acetylation cell growth, induced; apoptosis, induced; cell motility, altered; transcription, induced; transcription, altered; cell growth, altered HDAC3(DISRUPTS); NFkB-p65(INDUCES) DNA(INDUCES) 10788439; 10851065; 12730213; 15122339; 16061693; 16964287; 18443042; 36070687 84 65 16 -FBXO25 FBXO25 UBIQUITIN LIGASE; Ubiquitin conjugating system; Ubiquitin ligase Q8TCJ0 26260 8p23.3 human S178-p 37043701 DLLQDLSsTLCILIR protein degradation; intracellular localization apoptosis, induced 25419709 1 0 0 protein degradation of HAX1 -FEN1 FEN1 DNA repair, damage; DNA-binding; Deoxyribonuclease; EC 3.1.-.-; Nuclear receptor co-regulator; Nucleolus; Ribonuclease P39748 2237 11q12.2 human K377-ac 458857 TGAAGKFkRGK____ molecular association, regulation; enzymatic activity, inhibited DNA(DISRUPTS) 11430825 1 1 0 -Atg5 ATG5 Apoptosis; Autophagy; Ubiquitin conjugating system Q99J83 11793 10 B2|10 23.24 cM mouse T75-p 27138202 IWFEYEGtPLKWHYP autophagy, inhibited 23059785 2 0 0 -TGFBR2 TGFBR2 EC 2.7.11.30; KINASE; Kinase, protein; Membrane protein, integral; Oncoprotein; Protein kinase, Ser/Thr (receptor); Protein kinase, TKL P37173 7048 3p24.1 human S31-gl 1873645300 IPPHVQKsVNNDMIV molecular association, regulation; protein conformation signaling pathway regulation TGFBR1(DISRUPTS) 33234595 1 1 0 downstream TGF-? signaling -Tbxa2r TXA2-R GPCR, family 1; Membrane protein, integral; Membrane protein, multi-pass; Receptor, GPCR P30987 21390 10 C1|10 39.72 cM mouse T230-p 3061800 VYHTREAtQRPRDCE 7tm_1 receptor desensitization, altered 12428680 1 0 0 GRK2 mediated but not PKC -SSTR2 SSTR2 GPCR, family 1; Membrane protein, integral; Membrane protein, multi-pass; Receptor, GPCR P30874 6752 17q25.1 human Y71-p 469597 VIYVILRyAKMKTIT 7tm_1 molecular association, regulation apoptosis, induced PIK3R1(INDUCES) 16917505 1 0 0 complex with PIK3R1 dissociates in the presence of somatostatin -Pten PTEN Carbohydrate Metabolism - inositol phosphate; EC 3.1.3.16; EC 3.1.3.48; EC 3.1.3.67; Motility/polarity/chemotaxis; Nuclear receptor co-regulator; PHOSPHATASE; Phosphatase, lipid; Tumor suppressor O08586 19211 19 C1|19 28.14 cM mouse T383-p 448315 HYRYSDTtDSDPENE enzymatic activity, inhibited 24367090 23 3 0 -FLI1 FLI1 DNA-binding; Oncoprotein; Transcription factor Q01543 2313 11q24.3 human K397-ac 28108003 SYHAHQQkVNFVPPH transcription, induced 22973553 1 0 0 -MAP4 MAP4 Cytoskeletal; Motility/polarity/chemotaxis P27816 4134 3p21.31 human K1060-ac 62495521 DVKIESQkLNFKEKA Tubulin-binding cytoskeletal reorganization 28002468 1 1 0 -GP1BA GPIbA Cell adhesion; Cell surface; Membrane protein, integral P07359 2811 17p13.2 human S651-p 450660 SIRYSGHsL______ molecular association, regulation 14-3-3 sigma(INDUCES); 14-3-3 zeta(INDUCES) 10559231; 18299448; 19874472 4 5 0 -Cd22 CD22 Cell surface; Membrane protein, integral P35329 12483 7 B1|7 19.26 cM mouse Y828-p 450943 QKRPMGDyENVNPSC molecular association, regulation; activity, inhibited GRB2(INDUCES); PMCA1(INDUCES) 11551923; 27276708 6 0 1 negatively regulate calcium signal -KIF11 KIF11 Microtubule-binding; Motor P52732 3832 10q23.33 human Y211-p 463258 VHNKDEVyQILEKGA Kinesin cytoskeletal reorganization 28646493 1 1 3 spindle morphology -Pou2af1 POU2AF1 Oncoprotein; Transcription, coactivator/corepressor Q64693 18985 9|9 A5.3 mouse Y245-p 29570702 EEEESNTyELNHTLS PD-C2-AF1 protein stabilization 24061476 1 0 0 -TP53 p53 Activator; DNA-binding; Motility/polarity/chemotaxis; Nuclear receptor co-regulator; Transcription factor; Tumor suppressor P04637 7157 17p13.1 human K164-ub 486296 VRAMAIYkQSQHMTE P53 protein degradation; molecular association, regulation; intracellular localization transcription, altered DNA(INDUCES) 17371868; 28362432 2 2 0 differential transcription-activation or inhibition at specific promoters -DISC1 DISC1 Cell development/differentiation; Motility/polarity/chemotaxis Q9NRI5 27185 1q42.2 human K643-sm 62504401 VKKLGSVkEDYNRLR intracellular localization cell growth, induced 27525255 1 0 0 -Cttn Cortactin Actin-binding; Cytoskeletal; Motility/polarity/chemotaxis Q60598 13043 7|7 F5 mouse S113-p 465664 SKLSKHCsQVDSVRG HS1_rep molecular association, regulation ACTA1(DISRUPTS) 16854367 3 16 17 co-sedimentation assays with f-actin -STAT1 STAT1 DNA-binding; Transcription factor P42224 6772 2q32.2 human S727-p 447753 TDNLLPMsPEEFDEV STAT1_TAZ2bind activity, induced; sumoylation; molecular association, regulation; intracellular localization cell cycle regulation; carcinogenesis, induced; cell growth, inhibited; cell motility, induced; apoptosis, induced; transcription, induced; signaling pathway regulation; transcription, altered; cell growth, induced; apoptosis, inhibited; cell growth, altered PIAS1(INDUCES); BRCA1(INDUCES) DNA(INDUCES) 10792030; 11438544; 11777927; 11884587; 12637327; 12807916; 14962955; 15051500; 15322115; 15994321; 16799645; 17897103; 21303487; 21398617; 21878628; 31988137; 33727660; 33747209; 34626802; 35196494; 36113429; 36154299; 36342456; 37272165; 7543024 118 32 90 -EPB41 EPB41 iso2 Cytoskeletal P11171-2 2035 1p35.3 human T60-p 467259 LKASNGDtPTHEDLT molecular association, regulation; intracellular localization cell cycle regulation NuMA-1(INDUCES); TUBA4A(INDUCES) 15525677 1 10 1 Also associates with tubulin and NuMA in vivo. Mutant EPB41 T60A-S679A abolishes localization to the mitotic spindle. -RPS3 RPS3 Apoptosis; EC 4.2.99.18; RNA-binding; Ribosomal; Translation P23396 6188 11q13.4 human K18-sm 25218902 FVADGIFkAELNEFL protein stabilization 21968017 1 2 0 -Ncl NCL DNA-binding; Helicase; Nuclear receptor co-regulator; Nucleolus; RNA-binding P09405 17975 1 C5|1 43.94 cM mouse S28-p 452262 PKEVEEDsEDEEMSE molecular association, regulation carcinogenesis, induced; cell growth, induced; transcription, induced RNA(INDUCES) 37039106 2 45 9 -GATA4 GATA4 Motility/polarity/chemotaxis; Transcription factor P43694 2626 8p23.1 human S262-p 450013 IKPQRRLsASRRVGL activity, induced; molecular association, regulation transcription, induced DNA(INDUCES) 16109788; 26946174 9 1 1 -PFKL PFKL Carbohydrate Metabolism - fructose and mannose; Carbohydrate Metabolism - galactose; Carbohydrate Metabolism - glycolysis and gluconeogenesis; Carbohydrate Metabolism - pentose phosphate pathway; EC 2.7.1.11; Kinase, other P17858 5211 21q22.3 human S775-p 468408 HVTRRTLsMDKGF__ enzymatic activity, induced 25131207 1 53 16 -TRPV6 TRPV6 Channel, calcium; Membrane protein, integral; Membrane protein, multi-pass Q9H1D0 55503 7q34 human S732-p 1868023605 SRSTSRSsANWERLR activity, induced carcinogenesis, induced 32186440 1 0 0 -CTTN Cortactin Actin-binding; Cytoskeletal; Motility/polarity/chemotaxis Q14247 2017 11q13.3 human K235-ac 461721 YVKGFGGkFGVQTDR HS1_rep molecular association, regulation; intracellular localization cell motility, inhibited ACTB(DISRUPTS) 17643370 2 4 21 Acetylation prevents localization to membrane ruf?es. -Rptor Raptor Adaptor/scaffold Q8K4Q0 74370 11|11 E2 mouse S722-p 2314601 PRLRSVSsYGNIRAV phosphorylation transcription, altered; signaling pathway regulation; translation, inhibited 32912901 9 52 7 inhibits S6 and ULK1 phosphorylation through inhibiting mTORC1 signaling -EIF5A2 EIF5A2 Q9GZV4 56648 3q26.2 human K47-ac 18546316 IVEMSTSkTGKHGHA intracellular localization 23132580 1 5 0 acetylated was localized to the nucleus while hypoacetylated was cytoplasmic -MYC Myc DNA-binding; Nucleolus; Oncoprotein; Transcription factor P01106 4609 8q24.21 human K338-ac 458888 RKDYPAAkRVKLDSV Myc_N protein degradation; acetylation; molecular association, regulation cell growth, inhibited; apoptosis, induced; transcription, induced ZBTB17(INDUCES) 16126174; 27358484; 30866966 7 4 5 induces CCA cell apoptosis by decreasing cMYC; induces association with ZBTB17 on specific target promoters; HDACi-mediated TRAIL induction -RBL2 Rb-like 2 Transcription, coactivator/corepressor; Tumor suppressor Q08999 5934 16q12.2 human T401-p 449723 SKALRIStPLTGVRY molecular association, regulation cell cycle regulation; transcription, induced E2F4(DISRUPTS) 11157749; 12006580; 28289097 3 12 32 -GATA1 GATA1 DNA-binding; Transcription factor P15976 2623 Xp11.23 human K137-sm 3819000 TSFLETLkTERLSPD molecular association, regulation; intracellular localization cell growth, inhibited; transcription, inhibited; transcription, altered DNA(INDUCES) 20064464; 27821551; 35342335 4 0 0 decreased expression of CSN5 and ZEB1 -Otud5 OTUD5 DEUBIQUITINASE; EC 3.4.19.12; Protease; Ubiquitin-specific protease Q3U2S4 54644 X A1.1|X 3.54 cM mouse S323-p 1870773108 EDEPIRVsYHRNIHY OTU protein degradation; protein stabilization; molecular association, regulation; ubiquitination; phosphorylation; enzymatic activity, induced cell cycle regulation; cell growth, induced; autophagy, inhibited; transcription, altered; signaling pathway regulation BTRC(DISRUPTS) 33110214 1 1 0 inhibits ubiquitination and induces stabilization of OTUD5 and BTRCP1 further causing DEPTOR degradation, regulates phosphorylation of mTOR targets, promotes OTUD5-?TrCP1-DEPTOR pathway -BLVRA BVR Cofactor and Vitamin Metabolism - porphyrin and chlorophyll; EC 1.3.1.24; KINASE; Kinase, protein; Oxidoreductase; Protein kinase, Ser/Thr (non-receptor) P53004 644 7p13 human S230-p 478716 LKRNRYLsFHFKSGS Biliv-reduc_cat intracellular localization; enzymatic activity, induced; phosphorylation transcription, induced 17639074; 22584576 3 26 66 induces autophosphorylation of the protein and phosphorylation of PKCZ -Pdc phosducin G protein regulator, misc. P20942 25343 13q21 rat S36-p 10431702 WRKFKLEsEDGDSIP Phosducin molecular association, regulation G-gamma 2(DISRUPTS); G-beta 1(DISRUPTS) 11331285 1 0 1 -Pdgfrb PDGFRB EC 2.7.10.1; KINASE; Kinase, protein; Membrane protein, integral; Oncoprotein; Protein kinase, TK; Protein kinase, tyrosine (receptor) Q05030 rat Y856-p 447509 DIMRDSNyISKGSTF PK_Tyr_Ser-Thr cell motility, induced; cell growth, induced 34858182 17 2 3 -KEAP1 KEAP1 Endoplasmic reticulum; Motility/polarity/chemotaxis; Transcription regulation; UBIQUITIN LIGASE; Ubiquitin conjugating system Q14145 9817 19p13.2 human S602-p 29606703 TRMTSGRsGVGVAVT protein stabilization; molecular association, regulation carcinogenesis, inhibited; apoptosis, inhibited NRF2(INDUCES) 24127568 1 1 0 -CALR Calreticulin ACETYLTRANSFERASE; Acetyltransferase; Calcium-binding; Motility/polarity/chemotaxis; Nuclear receptor co-regulator; Secreted; Secreted, signal peptide P27797 811 19p13.13 human K209-ac 4219811 FLPPKKIkDPDASKP Calreticulin protein conformation 18795239 1 6 0 -SIAH2 SIAH2 EC 6.3.2.-; EC 6.3.2.19; Ligase; Transcription, coactivator/corepressor; UBIQUITIN LIGASE; Ubiquitin conjugating system; Ubiquitin ligase O43255 6478 3q25.1 human S68-p 5393502 GGGAGPVsPQHHELT protein degradation; molecular association, regulation; intracellular localization; enzymatic activity, induced cytoskeletal reorganization HIPK2(DISRUPTS) 19043406; 22878263; 23044042; 26751770 5 2 0 -FGFR2 FGFR2 EC 2.7.10.1; KINASE; Kinase, protein; Membrane protein, integral; Oncoprotein; Protein kinase, TK; Protein kinase, tyrosine (receptor) P21802 2263 10q26.13 human Y769-p 448113 TLTTNEEyLDLSQPL molecular association, regulation; enzymatic activity, induced cell growth, altered FRS2(INDUCES); PLCG1(INDUCES) 15629145 5 1 0 -GTF2I GTF2I DNA-binding; Transcription, coactivator/corepressor P78347 2969 7q11.23 human Y248-p 448250 EESEDPDyYQYNIQA activity, induced; intracellular localization transcription, induced; transcription, altered 15664986; 16738337; 20568114; 9837922 8 2 9 -HMGA1 HMGA1 DNA-binding P17096 3159 6p21.31 human T78-p 451516 KTRKTTTtPGRKPRG molecular association, regulation DNA(INDUCES) 17960875 3 7 2 Cdc2 phosphorylated HMGA1 has lower binding affinity than HIPK2 phosphorylated HMGA1. -TBL1XR1 TBL1XR1 Nuclear receptor co-regulator; Transcription, coactivator/corepressor Q9BZK7 79718 3q26.32 human K497-sm 20745209 CWNAAGDkVGASASD acetylation; molecular association, regulation carcinogenesis, induced; cell growth, induced; transcription, induced; signaling pathway regulation TCF4(INDUCES); SMRT(DISRUPTS); N-CoR1(DISRUPTS); HDAC3(DISRUPTS); CTNNB1(INDUCES) DNA(INDUCES) 21777810; 27129164 2 0 0 TCF4 was bound to TBL1X but not TBL1XR1, sumoylation enhances the recruitment to Wnt target gene promoters, activates Wnt signaling pathway ; induces histone acetylation -Prkcd PKCD EC 2.7.11.13; KINASE; Kinase, protein; Nuclear receptor co-regulator; Protein kinase, AGC; Protein kinase, Ser/Thr (non-receptor); Protein kinase, tyrosine (non-receptor); Tumor suppressor P09215 170538 16p16 rat Y311-p 447573 TPETVGIyQGFEKKT protein degradation; enzymatic activity, induced apoptosis, induced 10319993; 11381116; 14715667; 15961393; 18550549; 19161989 44 60 1707 -TRAIP TRAIP EC 6.3.2.-; Ligase; Nucleolus; UBIQUITIN LIGASE; Ubiquitin conjugating system; Ubiquitin ligase Q9BWF2 10293 3p21.31 human K247-sm 53529100 YSELDQAkLELKSAQ protein stabilization; ubiquitination; intracellular localization 26820530 2 0 0 inhibits ubiquitination -FANCI FANCI Cell cycle regulation; DNA repair, damage Q9NVI1 55215 15q26.1 human K523-ub 486579 CLILVLRkAMFANQL FANCI_S2 intracellular localization DNA repair, induced; DNA repair, inhibited 17460694; 20971953; 21896657; 22855611 8 10 93 -KPNA2 KPNA2 Karyopherin; Nuclear import; Nucleoporin P52292 3838 17q24.2 human K22-ac 458963 HRFKNKGkDSTEMRR IBB activity, induced; molecular association, regulation; intracellular localization HuR(INDUCES) 10801418; 15342649; 17919121 4 0 0 regulates HuR nuclear import through S105 phosphorylation and K22 acetylation ; promotes the nuclear localization of HuR; increases interaction with importin-beta in vitro -CERS4 LASS4 DNA-binding; Membrane protein, integral; Membrane protein, multi-pass Q9HA82 79603 19p13.2 human S342-p 7102766 QMEKDIRsDVEESDS enzymatic activity, induced 26887952 1 9 0 -POLI POLI DNA repair, damage; EC 2.7.7.7; Transferase Q9UNA4 11201 18q21.2 human K112-ub 50771303 NVRDAKEkCPQLVLV IMS protein degradation 26370087 1 3 0 -HIPK2 HIPK2 EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, CMGC; Protein kinase, Ser/Thr (non-receptor) Q9H2X6 28996 7q34 human S121-p 28847902 LMRRSTVsLLDTYQK protein stabilization; molecular association, regulation; phosphorylation; enzymatic activity, induced PPM1D(DISRUPTS) 23871434 1 0 0 increase protein stabilization and reduce phosphorylation of WIP1 -GAPDH GAPDH Carbohydrate Metabolism - glycolysis and gluconeogenesis; EC 1.2.1.12; Oxidoreductase P04406 2597 12p13.31 human T99-p 23109029 AEYVVEStGVFTTME Gp_dh_N enzymatic activity, induced 26629320 1 2 1 -Slc1a2 GLT1 Membrane protein, integral; Membrane protein, multi-pass; Transporter; Transporter, SLC family P31596 29482 3q32 rat S113-p 450073 SGLDAKAsGRLGTRA SDF activity, induced 7903307 1 0 0 -PLN PLB Inhibitor; Membrane protein, integral P26678 5350 6q22.31 human S16-p 448114 RSAIRRAsTIEMPQQ Phospholamban activity, induced; molecular association, regulation; activity, inhibited; protein conformation; enzymatic activity, induced SERCA2(DISRUPTS); ATP2A1(DISRUPTS) 11854448; 12134142; 18708665; 33897445; 35605666; 35805951 78 15 66 -FOXO1 FOXO1A DNA-binding; Nuclear receptor co-regulator; Oncoprotein; Transcription factor Q12778 2308 13q14.11 human K245-ac 459030 MLNPEGGkSGKSPRR Forkhead molecular association, regulation; intracellular localization; activity, inhibited; phosphorylation carcinogenesis, inhibited; apoptosis, induced; transcription, inhibited DNA(DISRUPTS) 15220471; 16076959; 18786403; 20519497; 27132507 9 1 0 -Mpl MPL Membrane protein, integral; Receptor, cytokine Q08351 17480 4 D2.1|4 54.61 cM mouse S522-p 3091402 LRHALWPsLPDLHRV activity, induced; phosphorylation cell growth, altered 10918061 1 0 0 tyrosine phosphorylation of JAK2 -CENPQ CENPQ Q7L2Z9 55166 6p12.3 human T123-p 40245503 RLLQQCEtLKVPPKK CENP-Q molecular association, regulation; intracellular localization DNA(DISRUPTS) 25670858 1 1 0 CENPQ phosphorylation promotes the delocalization of the PBIP1-CENPQ complex from kinetochores -Mob1b MOB1B Activator; Protein kinase, regulatory subunit Q8BPB0 68473 5|5 E1 mouse T12-p 3545000 FGSRSSKtFKPKKNI activity, induced; molecular association, regulation; protein conformation LATS1(INDUCES) 27335147 3 1 3 -FAAP20 FAAP20 iso2 Q6NZ36 199990 1p36.33 human S113-p 27445146 GAGGHLEsPARSLPQ FANCA_interact protein degradation; ubiquitination FBXW7(INDUCES) 27232758 2 10 0 -PPP1R13L PPP1R13L Apoptosis; Phosphatase, regulatory subunit; Transcription, coactivator/corepressor Q8WUF5 10848 19q13.32 human S113-p 465657 LHPYSPLsPKGRPSS molecular association, regulation; intracellular localization; protein conformation cell growth, inhibited p53(INDUCES); PPP1R13L(DISRUPTS) 23623661; 30105797 2 29 9 miR-129 inhibits phosphorylation, blocks nuclear localization and inhibits cell proliferation, p53 and TAp63 levels increased, inhibiting proliferation of Burkitt lymphoma cells; prevents N- and C-terminal self interaction, enhances binding to p53 -Ezh2 EZH2 EC 2.1.1.43; METHYLTRANSFERASE; Methyltransferase; Methyltransferase, protein lysine Q61188 14056 6 B2.3|6 22.92 cM mouse T345-p 4957354 LTAERIKtPPKRPGG protein degradation; molecular association, regulation RNA(INDUCES) 21123648; 30305391 11 12 2 -DEPTOR DEPTOR Apoptosis Q8TB45 64798 8q24.12 human S297-p 4723868 FSSSPTLsSSPPVLC protein degradation; molecular association, regulation carcinogenesis, induced; apoptosis, inhibited; signaling pathway regulation mTOR(DISRUPTS) 19446321 3 3 0 PI3K-Akt signaling -TAGAP TAGAP GAP; GAP, Rac/Rho Q8N103 117289 6q25.3 human Y310-p 6154570 TLQNDSAyDSNDPDV molecular association, regulation; intracellular localization; phosphorylation signaling pathway regulation CARD9(INDUCES) 32312989 1 1 1 induces phosphorylation of ERK and p38, regulates anti-fungal signaling pathway -EGFR EGFR EC 2.7.10.1; KINASE; Kinase, protein; Membrane protein, integral; Oncoprotein; Protein kinase, TK; Protein kinase, tyrosine (receptor) P00533 1956 7p11.2 human K1061-ac 49182100 GLQSCPIkEDSFLQR carcinogenesis, inhibited; cell motility, inhibited; signaling pathway regulation 26290602 1 1 0 inhibits EGFR-MAPK signaling -H3C1 H3 DNA-binding P68431 8350 6p22.2 human R17-m2 1968602 STGGKAPrKQLATKA Histone cell differentiation, inhibited; autophagy, induced; transcription, induced 15471871; 20022955; 23301034; 27309807 9 0 0 -STK38 NDR1 EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, AGC; Protein kinase, Ser/Thr (non-receptor) Q15208 11329 6p21.31 human T7-p 22553317 _MAMTGStPCSSMSN molecular association, regulation; intracellular localization; enzymatic activity, inhibited; protein conformation; phosphorylation cell cycle regulation; cytoskeletal reorganization; signaling pathway regulation MOB1A(DISRUPTS); HCCA2(INDUCES) 22142472; 26057687 2 1 0 induces JNK phosphorylation, regulates cell death through JNK signaling; regulation of spindle orientation, cortical localization of LGN-NuMA -TP53 p53 Activator; DNA-binding; Motility/polarity/chemotaxis; Nuclear receptor co-regulator; Transcription factor; Tumor suppressor P04637 7157 17p13.1 human K370-ne 12067102 RAHSSHLkSKKGQST transcription, inhibited 15242646 1 0 0 -Elk1 ELK1 DNA-binding; Transcription factor P41969 13712 X A1.3|X 16.45 cM mouse T354-p 22725900 QAPGPALtPSLLPTH molecular association, regulation transcription, induced MED16(INDUCES); MED23(INDUCES); Trap100(INDUCES) 27738173 2 0 0 -ADRB2 ADRB2 GPCR, family 1; Membrane protein, integral; Membrane protein, multi-pass; Receptor, GPCR P07550 154 5q32 human S396-p 457440 GHQGTVPsDNIDSQG protein conformation 21868357 4 1 0 -RELA NFkB-p65 DNA-binding; Nuclear receptor co-regulator; Transcription factor Q04206 5970 11q13.1 human K310-ub 25087015 KRTYETFkSIMKKSP transcription, inhibited 21706061 1 2 0 inhibits acetylation -SNIP1 SNIP1 Inhibitor Q8TAD8 79753 1p34.3 human S35-p 470652 VVKQERLsPEVAPPA sumoylation 27703003 1 66 5 S35 phosphorylation induces SNIP1 SUMOylation -FLNA FLNA Actin-binding; Motility/polarity/chemotaxis; Nuclear receptor co-regulator P21333 2316 Xq28 human S2523-p 448843 VTGPRLVsNHSLHET intracellular localization cytoskeletal reorganization 11290523 2 4 0 -ALDOA ALDOA Carbohydrate Metabolism - fructose and mannose; Carbohydrate Metabolism - glycolysis and gluconeogenesis; Carbohydrate Metabolism - pentose phosphate pathway; EC 4.1.2.13; KINASE; Lyase; Mitochondrial P04075 226 16p11.2 human S36-p 455261 GILAADEsTGSIAKR Glycolytic carcinogenesis, induced; cell growth, induced 31585088 1 43 2 -PARP3 PARP3 DNA repair, damage; EC 2.4.2.30; Transferase Q9Y6F1 10039 3p21.2 human S461-p 40682500 TDNPSLKsPPPGFDS PARP DNA repair, induced 25886813 1 1 0 -SSRP1 SSRP1 Nucleolus; RNA-binding; Transcription initiation complex; Transcription, coactivator/corepressor Q08945 6749 11q12.1 human S688-p 456296 KRRRSEDsEEEELAS activity, inhibited transcription, altered 15659405 1 0 0 -PARP1 PARP1 DNA repair, damage; EC 2.4.2.30; Nuclear envelope; Nuclear receptor co-regulator; Nucleolus; Transferase P09874 142 1q42.12 human S372-p 463804 VAATPPPsTASAPAA enzymatic activity, induced transcription, induced 16627622; 23597856 2 2 1 -Pias2 PIAS2 EC 6.3.2.-; Nuclear receptor co-regulator; SUMO LIGASE; SUMO conjugating system; SUMO ligase; Transcription, coactivator/corepressor Q6AZ28 83422 18q12.3 rat S116-p 464654 IAPHSPSsPVASVLL transcription, altered 16713578 1 0 0 important for Elk1-mediated transcriptional activation -Nr4a1 Nur77 Apoptosis; DNA-binding; Nuclear receptor P12813 15370 15|15 F1 mouse S142-p 2591500 GSPCSAPsPSTPNFQ intracellular localization transcription, altered 10878809 3 0 0 -EP300 p300 ACETYLTRANSFERASE; Acetyltransferase; EC 2.3.1.48; Motility/polarity/chemotaxis; Nuclear receptor co-regulator; Transcription, coactivator/corepressor Q09472 2033 22q13.2 human K1020-ac 458944 EERSTELkTEIKEEE activity, inhibited transcription, inhibited 15632193 2 1 0 -NFE2L2 NRF2 DNA-binding; Transcription factor Q16236 4780 2q31.2 human K472-ac 7106321 HIPFPVEkIINLPVV bZIP_Maf molecular association, regulation transcription, induced DNA(INDUCES) 19273602 1 1 0 -DHCR24 Diminuto EC 1.3.1.72; Lipid Metabolism - steroid biosynthesis; Membrane protein, integral; Oxidoreductase Q15392 1718 1p32.3 human Y507-p 449497 QDAFPEVyDKICKAA enzymatic activity, induced 24363437 1 1 14 -OPRK1 KOR-1 GPCR, family 1; Membrane protein, integral; Membrane protein, multi-pass; Receptor, GPCR P41145 4986 8q11.23 human K349-ub 1975301 RDFCFPLkMRMERQS receptor internalization, induced; protein degradation 18212250 1 0 0 ubiquitination regulates but is not required for receptor downregulation -Chrna7 nAChRA7 Channel, cation; Channel, ligand-gated; Membrane protein, integral; Membrane protein, multi-pass P49582 11441 7 C|7 34.47 cM mouse S365-p 451182 QHKPRRCsLASVELS Neur_chan_memb intracellular localization; activity, inhibited 25990637 2 0 0 -Dusp8 DUSP8 EC 3.1.3.16; EC 3.1.3.48; Motility/polarity/chemotaxis; PHOSPHATASE; Protein phosphatase, dual-specificity O09112 18218 7 F5|7 87.59 cM mouse S520-p 22598804 LDSPGTPsPDGPWCF enzymatic activity, inhibited signaling pathway regulation 22100391 1 1 0 activates JNK pathway -Stk39 STLK3 EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, STE; Protein kinase, Ser/Thr (non-receptor) Q9Z1W9 53416 2|2 C1.3 mouse T247-p 458885 VRKTFVGtPCWMAPE Pkinase enzymatic activity, induced 16382158 1 1 25 -TRIM25 TRIM25 EC 6.3.2.19; EC 6.3.2.n3; Ligase; Nuclear receptor co-regulator; Transcription factor; UBIQUITIN LIGASE; Ubiquitin conjugating system; Ubiquitin ligase Q14258 7706 17q22 human K439-ub 12332222 NSTSLKAkVLETFLA protein degradation; protein stabilization; intracellular localization 35079021 1 8 18 USP44 recruits and stabilizes TRIM25 and inhibits its ubiquitylation and promotes the ubiquitiylation and degradation of Ku80. USP44 increases the radiosensitivity of NPC nasopharyngeal carcinoma cells (NPC) in vivo. -MAP3K7 TAK1 EC 2.7.11.25; KINASE; Kinase, protein; Protein kinase, Ser/Thr (non-receptor); Protein kinase, TKL O43318 6885 6q15 human T538-p 971232900 QEYMKVQtEIALLLQ molecular association, regulation IKKG(INDUCES) 29511289 1 1 0 -Trpm7 ChaK1 Channel, cation; EC 2.7.11.1; KINASE; Kinase, protein; Membrane protein, integral; Membrane protein, multi-pass; Protein kinase, Ser/Thr (non-receptor); Protein kinase, atypical Q923J1 58800 2|2 F1 mouse S1567-p 455464 NLMRLSQsIPFVPVP molecular association, regulation; intracellular localization 14-3-3 theta(INDUCES) 29866880 3 9 0 S1403 is a stronger interaction site -Dnm1l DRP1 Apoptosis; EC 3.6.5.5; Endoplasmic reticulum; Hydrolase; Microtubule-binding; Mitochondrial; Motor Q8K1M6 74006 16|16 A2 mouse S622-p 454690 PIPIMPAsPQKGHAV activity, induced; intracellular localization carcinogenesis, induced; apoptosis, altered; carcinogenesis, inhibited; cell growth, inhibited; apoptosis, induced; cell motility, inhibited; transcription, altered; signaling pathway regulation; autophagy, induced; cell growth, induced; cytoskeletal reorganization; transcription, inhibited 25658204; 27739424; 30511961; 33485986; 33516941; 33539906; 33913175; 34535949; 34562609; 34631868; 34940790; 35165418; 35412849; 35791786; 35860026; 35865967; 36078152; 36327794; 36813093; 37232152 132 78 114 induces mitophagy; inhibits the cGMP-AMP synthase (cGAS) pathway -Cat Catalase Amino Acid Metabolism - tryptophan; Apoptosis; EC 1.11.1.6; Endoplasmic reticulum; Energy Metabolism - methane; Hydrolase; Mitochondrial; Oxidoreductase P24270 12359 2 E2|2 54.43 cM mouse Y386-p 450445 YRARVANyQRDGPMC Catalase protein degradation; enzymatic activity, induced 12950161 2 0 0 -JAK1 JAK1 EC 2.7.10.2; KINASE; Kinase, protein; Protein kinase, TK; Protein kinase, tyrosine (non-receptor) P23458 3716 1p31.3 human S518-p 62372201 GSDRSFPsLGDLMSH molecular association, regulation 27919027 1 0 0 -Lrp1 LRP1 Cell surface; Membrane protein, integral; Motility/polarity/chemotaxis; Receptor, misc. G3V928 299858 7q22 rat Y4474-p 473712 VEIGNPTyKMYEGGE molecular association, regulation GRB2(INDUCES); CSK(INDUCES); PLCB1(INDUCES); SNX17(DISRUPTS); PIK3R1(INDUCES) 19771558 4 3 2 -PHLPP1 PHLPP EC 3.1.3.16; PHOSPHATASE; Protein phosphatase, Ser/Thr (non-receptor); Tumor suppressor O60346 23239 18q21.33 human S411-p 1871700802 LPLPQTAsSPQPQQK cell cycle regulation 33397691 1 1 0 -Ikbkb IKKB EC 2.7.11.10; KINASE; Kinase, protein; Protein kinase, Other; Protein kinase, Ser/Thr (non-receptor) O88351 16150 8|8 A2 mouse S701-p 17934904 ACDSLPEsDKKSEEL molecular association, regulation; phosphorylation PPP2R3C(INDUCES) 20925653 1 0 0 interaction with PPP2R3C (aka G4-1) downregulates IKK-beta activity; S181 phosphorylation increased in S679/682/689/692/697/701/705A mutant -SPP1 osteopontin Secreted; Secreted, signal peptide P10451 6696 4q22.1 human S126-p 455739 QSDESHHsDESDELV Osteopontin molecular association, regulation; activity, inhibited Other(INDUCES) 19775205 1 5 0 peptide with phosphorylated S117, S120, S123, S126 and S129 has increased binding to hydroxyapatite, and inhibits bone mineralization in vivo and in vitro -EIF2AK2 PKR EC 2.7.10.2; EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, Other; Protein kinase, Ser/Thr (non-receptor); Protein kinase, tyrosine (non-receptor); Translation P19525 5610 2p22.2 human S242-p 448085 NQRKAKRsLAPRFDL enzymatic activity, induced 11152499 2 2 0 -BCL2 Bcl-2 Apoptosis; Autophagy; Membrane protein, integral; Oncoprotein P10415 596 18q21.33 human K22-ub 52477000 VMKYIHYkLSQRGYE BH4 protein degradation apoptosis, induced 26556865 1 1 0 increased cancer cell chemotherapy sensitivity -TOP2A TOP2A EC 5.99.1.3; Isomerase P11388 7153 17q21.2 human S1525-p 448764 PIKYLEEsDEDDLF_ molecular association, regulation; intracellular localization; enzymatic activity, induced cell cycle regulation; chromatin organization, altered; apoptosis, induced MDC1(INDUCES) 18171681; 19098900; 27407105 5 38 9 required for the decatenation checkpoint; required for normal sister chromatid segregationi late mitosis -SMAD7 SMAD7 DNA-binding; Transcription factor O15105 4092 18q21.1 human T96-p 15613800 EADLKALtHSVLKKL MH1 molecular association, regulation signaling pathway regulation TGFBR1(DISRUPTS) 20659902 2 0 0 regulates TGFB1 signaling -DDR1 DDR1 EC 2.7.10.1; KINASE; Kinase, protein; Membrane protein, integral; Protein kinase, TK; Protein kinase, tyrosine (receptor) Q08345 780 6p21.33 human Y484-p 1016886 GPREPPPyQEPRPRG activity, induced 24509848 0 5 46 phosphorylated in the N211QDDR1 mutant -USP1 USP1 DEUBIQUITINASE; EC 3.4.19.12; Protease; Ubiquitin conjugating system; Ubiquitin-specific protease O94782 7398 1p31.3 human S313-p 3177796 ATSDTLEsPPKIIPK UCH enzymatic activity, induced WDR48(INDUCES) 23116119 1 16 6 -FOXO1 FOXO1A DNA-binding; Nuclear receptor co-regulator; Oncoprotein; Transcription factor Q12778 2308 13q14.11 human T402-p 12607400 PGTMMQQtPCYSFAP intracellular localization transcription, altered 20061393 1 0 0 multiple site mutant (8A) -Tbc1d1 TBC1D1 DEUBIQUITINASE; GAP; GAP, Rab; Ubiquitin-specific protease Q60949 57915 5 C3.1|5 32.8 cM mouse S231-p 2103609 RPMRKSFsQPGLRSL transcription, inhibited 35061665 10 43 97 destabilizes PPARG -Crtc2 TORC2 Transcription, coactivator/corepressor Q3U182 74343 3|3 F1 mouse K628-ub 487505 DSSPGFSkEIAAALA TORC_C protein degradation 17805301 1 0 0 -FOS Fos DNA-binding; Motility/polarity/chemotaxis; Oncoprotein; Transcription factor P01100 2353 14q24.3 human S308-p 7388000 ADWEPLHsGSLGMGP protein stabilization 19285436 1 0 0 -Ywhab 14-3-3 beta Adaptor/scaffold P35213 56011 3q42 rat S65-p 467269 RSSWRVIsSIEQKTE 14-3-3 intracellular localization transcription, altered 12619878 1 2 0 Double mutant inhibited a MEF2 reporter and promotes nuclear localization of HDAC4/GFP. -GSK3A GSK3A EC 2.7.11.1; EC 2.7.11.26; KINASE; Kinase, protein; Protein kinase, CMGC; Protein kinase, Ser/Thr (non-receptor) P49840 2931 19q13.2 human Y279-p 447723 RGEPNVSyICSRYYR Pkinase enzymatic activity, induced apoptosis, altered 18701488 17 126 4206 -PRKCZ PKCZ EC 2.7.11.13; KINASE; Kinase, protein; Protein kinase, AGC; Protein kinase, Ser/Thr (non-receptor) Q05513 5590 1p36.33 human T410-p 447510 GPGDTTStFCGTPNY Pkinase molecular association, regulation; protein conformation; enzymatic activity, induced cytoskeletal reorganization TNNI1(INDUCES); desmin(INDUCES); TPM1(INDUCES); MYO1C(INDUCES); TNNT1(INDUCES) 10075713; 12887331; 12970779; 15314172; 16129678; 17335005; 17724026; 18258854; 20407013; 21281788 45 3 10 -SSB SSB Transcription initiation complex P05455 6741 2q31.1 human S366-p 449301 GKKTKFAsDDEHDEH activity, induced; activity, inhibited transcription, induced; transcription, inhibited 10983981; 18257391; 23231081; 9054510 10 68 130 inhibits recycling of RNA pol III complexes; S366A mutant had reduced viral gene expression. -Irs2 IRS2 Adaptor/scaffold; Motility/polarity/chemotaxis P81122 384783 8 A1.1|8 5.35 cM mouse S573-p 483923 GLRKRTYsLTTPARQ molecular association, regulation 14-3-3 beta(INDUCES) 22912850 2 40 11 -SMARCA4 SMARCA4 Cell cycle regulation; EC 3.6.1.-; EC 3.6.4.-; Helicase; Nuclear receptor co-regulator; Transcription, coactivator/corepressor; Tumor suppressor P51532 6597 19p13.2 human S35-p 1261736701 LGPSPGPsPGSAHSM protein degradation; molecular association, regulation; ubiquitination FBXW7(INDUCES) 30177679 1 0 0 -ALDOA ALDOA Carbohydrate Metabolism - fructose and mannose; Carbohydrate Metabolism - glycolysis and gluconeogenesis; Carbohydrate Metabolism - pentose phosphate pathway; EC 4.1.2.13; KINASE; Lyase; Mitochondrial P04075 226 16p11.2 human K13-ac 466408 PALTPEQkKELSDIA intracellular localization; enzymatic activity, induced carcinogenesis, induced; cell growth, induced 36209516 1 3 113 increased glycolysis which leading to tumor development and metastasis -FKBP1A FKBP12 EC 5.2.1.8; Isomerase P62942 2280 20p13 human K48-ub 22244556 RDRNKPFkFMLGKQE FKBP_C protein conformation 31375563 1 6 0 Partially unfolded but not aggregated drives FKBP12 ubiquitylation at the proteasome -Hnf4a HNF4 alpha DNA-binding; Nuclear receptor; Transcription factor P49698 15378 2 H3|2 84.32 cM mouse S303-p 20510205 DPDAKGLsDPGKIKR Hormone_recep molecular association, regulation SSU72(INDUCES) 34616001 2 1 0 -NR3C2 MCR DNA-binding; Nuclear receptor P08235 4306 4q31.23 human S459-p 386186600 FMDGSYFsFMDDKDY molecular association, regulation transcription, induced DNA(INDUCES) 29127314 1 0 0 ELISA-based transcription factor DNA binding assay (Tf-ELISA) -XRCC1 XRCC1 DNA repair, damage P18887 7515 19q13.31 human S408-p 3181459 YLMAGPGsSSEEDEA molecular association, regulation PARP1(DISRUPTS) 25477519 2 5 0 -HIF1A HIF1A Autophagy; DNA-binding; Transcription factor Q16665 3091 14q23.2 human K32-me 1883300100 AARSRRSkESEVFYE intracellular localization transcription, inhibited 35859119 1 1 0 Set7 upregulates HIF-1a target protein expression -HSPA1A HSP70 Chaperone; Heat shock protein; Motility/polarity/chemotaxis P0DMV8 3303 6p21.33 human S633-p 18010650 GPKGGSGsGPTIEEV intracellular localization apoptosis, induced 24623308 1 12 0 spindle elongation -Pax8 PAX8 Transcription factor Q00288 18510 2 A3|2 16.43 cM mouse K309-sm 5009200 PHSPFAIkQETPELS protein stabilization 18974227 1 0 0 -Esr2 ER-beta DNA-binding; Nuclear receptor O08537 13983 12 C3|12 33.52 cM mouse S236-p 473056 VRRQRSAsEQVHCLN protein degradation; molecular association, regulation; intracellular localization MDM2(INDUCES) 17166829; 22349818 2 0 0 -PLCG1 PLCG1 Carbohydrate Metabolism - inositol phosphate; EC 3.1.4.11; Motility/polarity/chemotaxis; Phospholipase P08487 281987 cow Y775-p 448907 EPDYGALyEGRNPGF enzymatic activity, induced transcription, altered 15879121 2 17 368 Mutation of Y775 or Y783 reduced PLCG1-mediated calcium mobilization and transcriptional activation -Clk2 CLK2 EC 2.7.12.1; KINASE; Kinase, protein; Protein kinase, CMGC; Protein kinase, dual-specificity (non-receptor) O35491 12748 3|3 F1 mouse T343-p 26375903 HHSTIVStRHYRAPE Pkinase enzymatic activity, induced 20074525 1 0 0 -AQP2 AQP2 Channel, misc.; Membrane protein, integral; Membrane protein, multi-pass; Transporter; Transporter, aquaporin family P41181 359 12q13.12 human T269-p 3339002 PQSLPRGtKA_____ molecular association, regulation; intracellular localization endocytosis, inhibited VTA1(DISRUPTS) 22778181; 28710278; 32486031; 32529500 37 5 0 -LBR LBR DNA-binding; Membrane protein, integral; Membrane protein, multi-pass G1N806 turkey S84-p 14575424 RSRSRSRsPGRPAKG molecular association, regulation; protein conformation H3(INDUCES) 22056509 2 5 0 -MCPH1 MCPH1 Cell cycle regulation Q8NEM0 79648 8p23.1 human S322-p 36125335 QKQAAGMsQETFEEK Microcephalin molecular association, regulation; phosphorylation signaling pathway regulation TOPBP1(INDUCES) 25301947 1 1 0 induces phosphrylation of RFA2, induce ATR signaling -TRIM28 TIF1B EC 6.3.2.-; KINASE; Kinase, protein; Ligase; Nuclear receptor co-regulator; Protein kinase, atypical; SUMO LIGASE; SUMO ligase; Transcription, coactivator/corepressor; UBIQUITIN LIGASE; Ubiquitin conjugating system; Ubiquitin ligase Q13263 10155 19q13.43 human K676-sm 3142607 CHVLPDLkEEDGSLS transcription, inhibited 31391303 2 2 0 loss of TF1B sumoylation induces dsRNA-activated IFN-mediated defenses that rely on RIG-I, MAVS, TBK1, and JAK1 transcription, SUMOylated TIF1B Is required to support efficient virus replication -Rb1 Rb Nuclear receptor co-regulator; Oncoprotein; Transcription, coactivator/corepressor; Tumor suppressor P13405 19645 14 38.73 cM|14 D3 mouse S781-p 450022 PIPHIPRsPYKFSSS Rb_C molecular association, regulation cell cycle regulation; transcription, inhibited E2F1(DISRUPTS) 10207050; 9671466 12 20 79 transcriptional downregulation of the E2F-1, E2F-2, dihydrofolate reductase, thymidine kinase, c-myc, proliferating-cell nuclear antigen, p107, and p21/Cip1 genes -PTTG1 Securin Cell cycle regulation; Oncoprotein O95997 9232 5q33.3 human S184-p 20764100 NLLQSPSsILSTLDV Securin protein degradation cell cycle regulation 21757741 2 0 0 -TAF1C TAF1C Transcription initiation complex Q15572 9013 16q24.1 human T852-p 31864668 ATRSQQHtPVLSSSQ cell cycle regulation; transcription, inhibited 26023773 1 3 0 -ARHGAP25 ARHGAP25 GAP; GAP, Rac/Rho P42331 9938 2p13.3 human S379-p 14822408 KAPVARSsVGWDATE endocytosis, induced; cytoskeletal reorganization 36190314 1 5 2 -ACADVL ACADVL EC 1.3.8.9; Lipid Metabolism - fatty acid; Mitochondrial; Oxidoreductase P49748 37 17p13.1 human K507-sc 40477504 LLLGEAGkQLRRRAG molecular association, regulation CRLS1(INDUCES) 25811481 1 0 0 both SIRT3 and SIRT5 KO show reduced afinity for CRLS1 -NEUROG3 neurogenin 3 Cell development/differentiation; DNA-binding; Transcription factor Q9Y4Z2 50674 10q22.1 human S183-p 35527103 VSQAGSLsPAASLEE transcription, inhibited 28441528 2 0 0 -CTCF CTCF C2H2-type zinc finger protein; Transcription factor; Tumor suppressor P49711 10664 16q22.1 human K689-sm 6124704 ENIIVEVkKEPDAEP transcription, induced 22354964 2 3 0 -CDKN1C p57Kip2 Cell cycle regulation; Inhibitor; Nuclear receptor co-regulator; Tumor suppressor P49918 1028 11p15.4 human T310-p 450869 GVGSVEQtPRKRLR_ protein degradation; molecular association, regulation SKP2(INDUCES) 12925736; 23421998 3 1 2 DN-Akt stabilized p57 -RGS19 RGS19 GAP; GAP, RGS P49795 10287 20q13.33 human S151-p 447873 EDYVSILsPKEVSLD RGS activity, induced 10993892; 15488168 2 1 0 -RUNX3 AML2 DNA-binding; Transcription factor Q13761 864 1p36.11 human K148-ub 11998601 VGRSGRGkSFTLTIT Runt protein degradation; intracellular localization transcription, inhibited 19808967 1 0 0 nuclear export -SCN8A SCN8A Channel, sodium; Membrane protein, integral; Membrane protein, multi-pass Q9UQD0 6334 12q13.13 human S561-p 1869659200 PFLSRHNsKSSIFSF Na_trans_cytopl activity, induced neural plasticity 32611770 1 1 0 Regulates voltage-gated sodium channel Nav1.6 activity and neuronal excitability -CYP3A4 CYP3A4 Cell surface; Cofactor and Vitamin Metabolism - retinol; EC 1.14.14.1; Lipid Metabolism - linoleic acid; Membrane protein, integral; Oxidoreductase; Xenobiotic Metabolism - drug metabolism - cytochrome P450; Xenobiotic Metabolism - drug metabolism - other enzymes; Xenobiotic Metabolism - metabolism by cytochrome P450 P08684 1576 7q22.1 human T264-p 5938005 KESRLEDtQKHRVDF p450 protein degradation; ubiquitination 19095658; 22101235; 25451919 3 2 0 -NFE2L2 NRF2 DNA-binding; Transcription factor Q16236 4780 2q31.2 human S408-p 10292700 GDMVQPLsPSQGQST activity, induced; protein degradation; protein stabilization; molecular association, regulation; ubiquitination; intracellular localization transcription, induced; transcription, inhibited; signaling pathway regulation BTRC(INDUCES); PIN1(INDUCES); FBW1B(INDUCES) 19668370; 31805502; 34918396; 37627580 4 5 0 -Cnr1 CNR1 GPCR, family 1; Membrane protein, integral; Membrane protein, multi-pass; Receptor, GPCR P47746 12801 4 A5|4 16.28 cM mouse S426-p 999609 TAQPLDNsMGDSDCL receptor desensitization, induced 24719095 3 4 0 -ANKRD55 ANKRD55 Unknown function Q3KP44 79722 5q11.2 human S436-p 1869465809 LPPIRTQsLPPITLG molecular association, regulation 14-3-3 beta(INDUCES) 31620119 0 1 0 -SENP3 SENP3 DESUMOYLASE; EC 3.4.22.68; Nucleolus; Protease; Sumo-specific protease Q9H4L4 26168 17p13.1 human S143-p 36438203 LLYSKSTsLTFHWKL molecular association, regulation; intracellular localization NPM1(INDUCES) 25288641 1 1 0 ribosome biogenesis-28S rRNA maturation -ARHGAP35 GRF-1 GAP; GAP, Rac/Rho; Motility/polarity/chemotaxis; Transcription factor; Tumor suppressor Q9NRY4 2909 19q13.32 human S296-p 14574213 NENWLSVsRKMQASP RhoGAP-FF1 molecular association, regulation eIF3-theta(INDUCES) 28007963 1 1 0 -CD151 CD151 Membrane protein, integral; Membrane protein, multi-pass P48509 977 11p15.5 human K8-ub 4666606 MGEFNEKkTTCGTVC protein degradation 18713730 1 2 0 cell surface downregulation of tetraspanins -PDGFRB PDGFRB EC 2.7.10.1; KINASE; Kinase, protein; Membrane protein, integral; Oncoprotein; Protein kinase, TK; Protein kinase, tyrosine (receptor) P09619 5159 5q32 human Y970-p 4833940 GEGYKKKyQQVDEEF enzymatic activity, induced cell motility, altered 19275932 1 2 0 in vitro -Pten PTEN Carbohydrate Metabolism - inositol phosphate; EC 3.1.3.16; EC 3.1.3.48; EC 3.1.3.67; Motility/polarity/chemotaxis; Nuclear receptor co-regulator; PHOSPHATASE; Phosphatase, lipid; Tumor suppressor O08586 19211 19 C1|19 28.14 cM mouse T366-p 449634 ASSSTSVtPDVSDNE protein stabilization cell growth, inhibited 20940307; 35603900 7 4 0 -G0s2 G0S2 Apoptosis; Mitochondrial Q61585 14373 1 H6|1 97.69 cM mouse K25-ub 56709106 KPRGKLVkLYVLGSV G0-G1_switch_2 protein degradation 27248498 1 0 0 -H4C1 H4 DNA-binding P62805 8359 6p22.2 human K91-ub 12106858 MDVVYALkRQGRTLY CENP-T_C DNA repair, induced; carcinogenesis, inhibited 19818714; 25605023 2 9 12 -Cdx2 CDX2 DNA-binding; Transcription factor P43241 12591 5 G3|5 86.86 cM mouse S60-p 460651 ANLDSAQsPGPSWPT Caudal_act transcription, inhibited 11729123; 21737780 3 0 0 regulates cell differentiation -UBB UBB Apoptosis; Cell cycle regulation; Cell development/differentiation; Motility/polarity/chemotaxis; Transcription regulation; Ubiquitin-like modifier P0CG47 7314 17p11.2 human T12-p 13302272 VKTLTGKtITLEVEP ubiquitin ubiquitination; intracellular localization cell growth, inhibited; DNA repair, inhibited 33022275 1 3 0 induces histone deubiquitination and inhibits p53 localization to chromatin further inhibiting NHEJ -EEF2 EEF2 Translation; Translation elongation P13639 1938 19p13.3 human Y265-p 457573 KKLWGDRyFDPANGK GTP_EFTU sumoylation 24648518 1 1 5 induces sumoylation at K322 and K529 -PPARGC1A PGC-1 alpha Nuclear receptor co-regulator; Transcription, coactivator/corepressor Q9UBK2 10891 4p15.2 human T299-p 448009 AGLTPPTtPPHKANQ protein stabilization 11741533 2 1 1 -Nolc1 NOLC1 Nucleolus; RNA-binding; Transcription, coactivator/corepressor P41777 64896 1q54 rat S113-p 455684 AAPAKRAsLPQHAGK activity, induced transcription, altered 12167624 1 5 0 -CAMK2A CAMK2A EC 2.7.11.17; KINASE; Kinase, protein; Protein kinase, CAMK; Protein kinase, Ser/Thr (non-receptor) Q9UQM7 815 5q32 human T306-p 449596 LKGAILTtMLATRNF molecular association, regulation; enzymatic activity, inhibited; intracellular localization NMDAR2B(DISRUPTS) 16436603; 21768120; 34391760 18 10 2 -Cited1 CITED1 Nuclear receptor co-regulator P97769 12705 X D|X 45.25 cM mouse S79-p 8112774 GSPTATPsSKPPSFN CITED intracellular localization cell differentiation, altered; cell differentiation, induced; transcription, altered 23529225; 25049079 2 0 0 nuclear translocation ALP2, RUNX2 and Osteocalcin gene expression altered; S63/64/65/67/69/73/79/80/84A mutation in CITED1 inhibits its translocation into the nucleus and osteoblasts differentiation -Eif4ebp1 4E-BP1 Translation; Translation initiation Q62622 116636 16q12.3 rat S111-p 447526 KRAGGEEsQFEMDI_ eIF_4EBP molecular association, regulation EIF4E(DISRUPTS) 11146653 5 15 28 -RAD51 RAD51 DNA repair, damage; Mitochondrial Q06609 5888 15q15.1 human K57-sm 1879760604 EAVAYAPkKELINIK molecular association, regulation DNA repair, induced BRCA2(INDUCES) 35061896 1 0 0 RAD51 SUMOylation is required for HR-mediated DSB repair, GFP-TOPORS-WT restored the interaction between RAD51 and BRCA2, but the T515A mutant restored to a lesser degree -Exoc8 EXOC8 Vesicle O54924 245709 19q12 rat S92-p 182950100 HLLTEQKsSLESIPL Vps51 molecular association, regulation exocytosis, inhibited Sec5(DISRUPTS); EXOC8(DISRUPTS) 28325821 1 1 0 -Irs2 IRS2 Adaptor/scaffold; Motility/polarity/chemotaxis P81122 384783 8 A1.1|8 5.35 cM mouse S1098-p 3217320 TSGLKRLsLMDQVSG protein degradation cell cycle regulation 25830382 1 7 0 -DRD2 DRD2 iso2 GPCR, family 1; Membrane protein, integral; Membrane protein, multi-pass; Receptor, GPCR P14416-2 1813 11q23.2 human S229-p 487433 RVNTKRSsRAFRAHL 7tm_1 receptor desensitization, induced; receptor recycling, induced 23082996 2 0 0 PKC mediated receptor desensitization and internalization -L1cam NCAM-L1 Cell adhesion; Membrane protein, integral Q05695 50687 Xq37 rat S1183-p 465573 GEYRSLEsDNEEKAF Bravo_FIGEY neural plasticity 33500315 6 23 5 -Cttn Cortactin Actin-binding; Cytoskeletal; Motility/polarity/chemotaxis Q60598 13043 7|7 F5 mouse Y334-p 450862 VVQVPSAyQKTVPIE cell cycle regulation; cell motility, altered 18515860 2 21 318 -PPP5C PPP5C EC 3.1.3.16; PHOSPHATASE; Protein phosphatase, Ser/Thr (non-receptor) P53041 5536 19q13.32 human K199-ub 41493185 KELMQWYkDQKKLHR PPP5 protein degradation; ubiquitination 29141220 1 4 0 -NFKB1 NFkB-p105 DNA-binding; Transcription factor P19838 4790 4q24 human K440-ac 465126 GTMDTESkKDPEGCD molecular association, regulation; intracellular localization DNA(INDUCES) 11739381 1 2 0 nuclear translocation -YAP1 YAP1 Oncoprotein; Transcription, coactivator/corepressor P46937 10413 11q22.1 human K280-sm 6094307 ISQSAPVkQPPPLAP protein stabilization; ubiquitination apoptosis, induced; transcription, induced 19111660 1 0 0 inhibits ubiquitination -Prkd1 PRKD1 Autophagy; EC 2.7.11.13; KINASE; Kinase, protein; Motility/polarity/chemotaxis; Protein kinase, CAMK; Protein kinase, Ser/Thr (non-receptor) Q62101 18760 12|12 B3 mouse S427-p 4960330 KHTKRRSsTVMKEGW intracellular localization; enzymatic activity, inhibited cell growth, inhibited; transcription, inhibited; signaling pathway regulation 24643961 2 1 3 -Dok3 DOK3 Adaptor/scaffold Q9QZK7 27261 13|13 B1 mouse Y343-p 454686 TGTAEHLyENVCMLE molecular association, regulation SHIP(INDUCES) 14993273 1 4 76 -Cnp CNP Cell development/differentiation; EC 3.1.4.37; Phosphodiesterase P13233 25275 10q31 rat K385-ac 4132177 RWMLSLAkKMEVKAI CNPase enzymatic activity, inhibited; protein conformation 34330062 1 1 1 -Sh3pxd2a Tks5 Adaptor/scaffold O89032 14218 19|19 C3 mouse S566-p 3199157 VPAFGFDsEPEMNEE cell cycle regulation; cell motility, altered 18515860 0 14 15 -HNRNPK hnRNP K RNA splicing; RNA-binding; Spliceosome P61978 3190 9q21.32 human K422-sm 2894422 HESGASIkIDEPLEG KH_1 protein stabilization; molecular association, regulation; ubiquitination; intracellular localization cell cycle regulation; transcription, induced MDM2(DISRUPTS); p53(INDUCES) DNA(INDUCES) 23092970 2 5 0 prevents ubiquitination -PLAU uPA EC 3.4.21.73; Motility/polarity/chemotaxis; Protease; Secreted; Secreted, signal peptide P00749 5328 10q22.2 human S323-p 451053 TGFGKENsTDYLYPE Trypsin molecular association, regulation; intracellular localization cell motility, altered; cell adhesion, altered; cytoskeletal reorganization ITGA5(INDUCES); ITGB5(INDUCES) 18844213; 9151681 3 0 0 reduces ITGB5/ITGA5 activation and its interaction with vitronectin and talin; ligand-dependent uPA redistribution severely impaired in a S158/323E mutant -NCL NCL DNA-binding; Helicase; Nuclear receptor co-regulator; Nucleolus; RNA-binding P19338 4691 2q37.1 human T84-p 9765542 PAKKAAVtPGKKAAA molecular association, regulation cell cycle regulation; cell growth, induced DDX31(INDUCES) 29440146; 37276927 2 14 6 -LRP1 LRP1 Cell surface; Membrane protein, integral; Motility/polarity/chemotaxis; Receptor, misc. Q07954 4035 12q13.3 human S4523-p 7103863 GSRHSLAsTDEKREL molecular association, regulation; receptor internalization, altered GULP1(INDUCES); DAB1(INDUCES); SHC1(INDUCES) 15272003 1 20 0 -PI4K2A PI4K2A EC 2.7.1.67; Kinase, lipid; Motility/polarity/chemotaxis Q9BTU6 55361 10q24.2 human S9-p 2022757 DETSPLVsPERAQPP endocytosis, inhibited 37314927 2 16 0 -ADD2 ADD2 Cytoskeletal; Motility/polarity/chemotaxis P35612 119 2p13.3 human S726-p 449803 KKKEKVEs_______ protein degradation; intracellular localization cytoskeletal reorganization 16116087; 9679146 2 0 0 -Id2 ID2 DNA-binding; Transcription, coactivator/corepressor P41137 25587 6q16 rat S5-p 451265 ___MKAFsPVRSVRK intracellular localization cell cycle regulation; transcription, altered; cell growth, altered 11706002 4 6 0 -WDR77 WDR77 Adaptor/scaffold; Nuclear receptor co-regulator; Transcription, coactivator/corepressor Q9BQA1 79084 1p13.2 human S264-p 17797201 CVTGLVFsPHSVPFL carcinogenesis, altered 20951943 1 1 0 in CCND1 T286A mutant -IRF8 IRF8 DNA-binding; Transcription factor Q02556 3394 16q24.1 human Y107-p 2299204 QLDISEPyKVYRIVP IRF transcription, inhibited 18195016 2 0 0 represses PTPN13 promoter activity -Dyrk1a DYRK1A EC 2.7.12.2; KINASE; Kinase, protein; Protein kinase, CMGC; Protein kinase, dual-specificity (non-receptor) Q63470 25255 11q11 rat Y321-p 448553 LGQRIYQyIQSRFYR Pkinase enzymatic activity, induced 11672423; 12604362; 8631952 5 145 3685 -GLIS2 GLIS2 C2H2-type zinc finger protein Q9BZE0 84662 16p13.3 human S245-p 17790902 PTCSKSFsRLENLKI zf-C2H2 molecular association, regulation; activity, inhibited transcription, inhibited DNA(DISRUPTS) 21127075 1 1 0 -Mastl MASTL EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, AGC; Protein kinase, Ser/Thr (non-receptor) Q8C0P0 67121 2|2 A3 mouse T297-p 1269647500 QCRKRLGtSSTSSQS activity, induced cell cycle regulation; signaling pathway regulation 30293837 2 0 0 inhibits pronuclei onset (PN onset) -MAP1LC3A LC3A Autophagy; Microtubule-binding; Ubiquitin-like modifier; Vesicle Q9H492 84557 20q11.22 human K49-ac 38557704 KQLPVLDkTKFLVPD ATG8 molecular association, regulation; intracellular localization autophagy, inhibited DOR-1(DISRUPTS); ATG7(DISRUPTS) 25601754 1 0 0 -Mapk14 P38A EC 2.7.11.24; KINASE; Kinase, protein; Protein kinase, CMGC; Protein kinase, Ser/Thr (non-receptor) P47811 26416 17 A3.3|17 14.85 cM mouse Y323-p 455799 DEPVADPyDQSFESR activity, induced; protein conformation; enzymatic activity, induced cell cycle regulation; cell growth, induced; signaling pathway regulation 19011223; 19324872; 21715315; 26517532 8 1 0 decreased IFN-gamma production in TCR-activated p38-alpha Y322F cells; ; in vitro; proliferation of p38-alpha Y322F T cells stimulated with anti-CD3/CD28, but not with PMA and ionomycin is delayed; dopaminergic neuronal cell death; p38 pathway activation, Induce T cell proliferation and Th Skewing, reduce autoimmunity and inflammation -TP53BP1 53BP1 DNA repair, damage; Transcription, coactivator/corepressor Q12888 7158 15q15.3 human R1401-me 2344817 TPRGRGRrGRPPSRT molecular association, regulation DNA(INDUCES) 16294045 2 0 0 -CENPT CENPT DNA replication Q96BT3 80152 16q22.1 human T195-p 459758 SLNLTFAtPLQPQSV CENP-T_N molecular association, regulation; intracellular localization cell cycle regulation 21529714; 25660545 2 2 1 localization of Ndc80/Hec1, controls kinetochore assembly, increases cell viability; KMN network recruitment -CSNK1A1 CK1A EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, CK1; Protein kinase, Ser/Thr (non-receptor) P48729 1452 5q32 human K8-ub 41484588 MASSSGSkAEFIVGG protein degradation 26909574 1 4 0 -Bcl10 Bcl-10 Apoptosis; Transcription, coactivator/corepressor; Tumor suppressor Q9Z0H7 12042 3|3 H2 mouse S138-p 470125 NNLSRCNsDESNLSE activity, induced; protein degradation 17502353 7 30 18 -KIF2C KIF2C Cancer Testis Antigen (CTA); Microtubule-binding; Motility/polarity/chemotaxis; Motor Q99661 11004 1p34.1 human S95-p 451107 IQKQKRRsVNSKIPA molecular association, regulation; intracellular localization; activity, inhibited cytoskeletal reorganization EB1(DISRUPTS) 14960279; 19632184 5 4 3 involved in microtubule tip tracking -Rhoq RHOQ G protein; G protein, monomeric; G protein, monomeric, Rho; Motility/polarity/chemotaxis Q8R527 104215 17 E4|17 56.9 cM mouse T189-p 5996401 ILTPKKHtVKKRIGS intracellular localization cytoskeletal reorganization 18948252 1 0 0 -HSP90AA1 HSP90A Chaperone; Heat shock protein P07900 3320 14q32.31 human R345-m1 57739897 RALLFVPrRAPFDLF HSP90 molecular association, regulation apoptosis, inhibited AHSA1(INDUCES) 31765670 1 2 0 -ERBB4 HER4 EC 2.7.10.1; KINASE; Kinase, protein; Membrane protein, integral; Protein kinase, TK; Protein kinase, tyrosine (receptor) Q15303 2066 2q34 human Y1202-p 4825105 PPKAEDEyVNEPLYL molecular association, regulation GRB2(INDUCES); Syk(INDUCES) 16729043; 18721752 1 1 1 -Csf1r CSFR EC 2.7.10.1; KINASE; Kinase, protein; Membrane protein, integral; Oncoprotein; Protein kinase, TK; Protein kinase, tyrosine (receptor) P09581 12978 18 E1|18 34.41 cM mouse Y544-p 2866400 KYKQKPKyQVRWKII enzymatic activity, induced cell differentiation, altered; cell growth, altered 18519746 4 0 0 -NUB1 NYREN18 Ubiquitin conjugating system Q9Y5A7 51667 7q36.1 human S46-p 1868140201 KDLAKQYsDRLECCE molecular association, regulation; activity, inhibited SNCA(INDUCES) 31006160 1 0 0 -OGG1 OGG1 DNA repair, damage; Deoxyribonuclease; EC 4.2.99.18; Lyase O15527 4968 3p25.3 human K341-ub 1877126900 AKRRKGSkGPEG___ enzymatic activity, inhibited DNA repair, induced 33282879 1 0 0 reduced cell survival in response to IR -MICAL1 MICAL1 Adaptor/scaffold; EC 1.14.13.-; Motility/polarity/chemotaxis Q8TDZ2 64780 6q21 human S817-p 5434440 SPERQRLsSLNLTPD molecular association, regulation cytoskeletal reorganization 14-3-3 epsilon(INDUCES); Rab7(INDUCES); RAB10(INDUCES) 36198272 1 3 27 -Cacna1b CACNA1B Channel, calcium; Membrane protein, integral; Membrane protein, multi-pass Q02294 257648 3p13 rat S896-p 455283 ERARPRRsHSKEAPG activity, inhibited 11312277 2 0 0 Phosphorylation by PKC prevents effects of syntaxin 1A on voltage dependent inactivation of N-type calcium channels. -CDK1 CDK1 Cell cycle regulation; EC 2.7.11.22; EC 2.7.11.23; KINASE; Kinase, protein; Motility/polarity/chemotaxis; Protein kinase, CMGC; Protein kinase, Ser/Thr (non-receptor) P06493 983 10q21.2 human Y4-p 473276 ____MEDyTKIEKIG Pkinase protein degradation; ubiquitination cell cycle regulation 20395957 1 2 4 -PRKAR2A PKAR2A Protein kinase, regulatory subunit P13861 5576 3p21.31 human S78-p 4702645 VADAKGDsESEEDED carcinogenesis, induced 36114575 3 59 47 -ASF1A ASF1A DNA repair, damage; Histone-binding Q9Y294 25842 6q22.31 human S166-p 3245981 KLEDAESsNPNLQSL molecular association, regulation; ubiquitination; intracellular localization; phosphorylation cell cycle regulation; DNA repair, induced; signaling pathway regulation MDC1(INDUCES) 33503415 2 11 2 induces H2AX, ATM, MDC1 phosphorylation, thus regulating H2A/X-ATM-MDC1-RNF8 signaling, resulting in 53BP1 localization and histone ubiquitination -EIF2AK3 PERK EC 2.7.11.1; KINASE; Kinase, protein; Membrane protein, integral; Protein kinase, Other; Protein kinase, Ser/Thr (non-receptor); Translation Q9NZJ5 9451 2p11.2 human T982-p 447936 MPAYARHtGQVGTKL Pkinase enzymatic activity, induced cell cycle regulation; carcinogenesis, inhibited; apoptosis, induced 14676213; 31906029; 34615996; 35331268 26 0 0 -Rhoa RHOA G protein; G protein, monomeric; G protein, monomeric, Rho; Motility/polarity/chemotaxis; Oncoprotein Q9QUI0 11848 9|9 F1-F2 mouse S188-p 449035 ARRGKKKsGCLIL__ activity, inhibited transcription, altered; transcription, inhibited 15102857; 19737918 17 0 0 -YAP1 YAP1 Oncoprotein; Transcription, coactivator/corepressor P46937 10413 11q22.1 human Y188-p 56813400 KTSSGQRyFLNHIDQ WW activity, induced; molecular association, regulation; intracellular localization carcinogenesis, induced; cell motility, induced; cell growth, induced LATS1(DISRUPTS); PTPN14(DISRUPTS) 27428284 1 1 0 -Pld2 PLD2 EC 3.1.4.4; Lipid Metabolism - ether lipid; Lipid Metabolism - glycerophospholipid; Motility/polarity/chemotaxis; Phospholipase P97813 18806 11 B3|11 42.99 cM mouse Y165-p 453411 HTASKQKyLENYLNR PX intracellular localization; phosphorylation; enzymatic activity, induced 15282299 1 0 0 -Rps6kb1 p70S6K EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, AGC; Protein kinase, Ser/Thr (non-receptor); Translation P67999 83840 10q26 rat T412-p 448607 NQVFLGFtYVAPSVL Pkinase_C enzymatic activity, induced 11516946; 11705993; 11861821; 15774499; 17220300; 36224569; 9632736 476 9 1 -PML PML iso3 Nucleolus; Oncoprotein; SUMO LIGASE; SUMO conjugating system; SUMO ligase; Transcription factor; Tumor suppressor; Ubiquitin conjugating system P29590-3 5371 15q24.1 human S117-p 455494 ESLQRRLsVYRQIVD apoptosis, induced 12402044 1 0 0 -FZR1 FZR1 UBIQUITIN LIGASE; Ubiquitin conjugating system Q9UM11 51343 19p13.3 human S40-gl 55596602 PASSPVSsPSKHGDR activity, induced; molecular association, regulation CDC27(INDUCES) 27080259 1 1 0 promotes the interaction between FZR1 and APC/C subunits, enhances APC/C activity -LTF LTF EC 3.4.21.-; Protease; Secreted; Secreted, signal peptide P02788 4057 3p21.31 human S54-gl 13421408 KVRGPPVsCIKRDSP Transferrin protein stabilization transcription, inhibited 20404350 1 0 0 blocking ubiquitin dependent proteolysis -Mapt Tau ACETYLTRANSFERASE; Acetyltransferase; Cytoskeletal P10637 17762 11 67.79 cM|11 E1 mouse K466-ac 55529800 NATRIPAkTTPSPKT protein stabilization; intracellular localization transcription, induced; translation, induced 33910019 5 1 0 increases protein synthesis, K174ac nuclear accumulation, induces rDNA relaxation, nucleolar expansion -DOK2 DOK2 Adaptor/scaffold O60496 9046 8p21.3 human Y139-p 449649 CMEENELySSAVTVG molecular association, regulation DOK2(INDUCES); DOK1(INDUCES) 16177091 2 5 107 Dok1/Dok2 oligomerization required for ERK1/2 and NFAT activation -Per2 PER2 Nuclear receptor co-regulator; Nucleolus; Transcription factor O54943 18627 1|1 D mouse S659-p 449331 TLPGKAEsVVSLTSQ protein degradation; protein stabilization; intracellular localization 16983144; 26431025 8 1 1 two competing phosphorylation sites determine whether PER2 has a fast or slow degradation rate, regulated by temperature -Smtnl1 SMTNL1 Q99LM3 68678 2|2 D mouse S301-p 2755200 RAPERRVsAPSRPRG molecular association, regulation; activity, inhibited TPM1(INDUCES); Calmodulin(DISRUPTS) 18310078; 28320308 3 1 0 -ALDH1B1 ALDH1B1 Amino Acid Metabolism - arginine and proline; Amino Acid Metabolism - histidine; Amino Acid Metabolism - lysine degradation; Amino Acid Metabolism - tryptophan; Amino Acid Metabolism - valine, leucine and isoleucine degradation; Carbohydrate Metabolism - ascorbate and aldarate; Carbohydrate Metabolism - butanoate; Carbohydrate Metabolism - glycolysis and gluconeogenesis; Carbohydrate Metabolism - propanoate; Carbohydrate Metabolism - pyruvate; EC 1.2.1.3; Lipid Metabolism - fatty acid; Lipid Metabolism - glycerolipid; Mitochondrial; Other Amino Acids Metabolism - beta-alanine; Oxidoreductase; Secondary Metabolites Metabolism - limonene and pinene degradation P30837 219 9p13.1 human K506-ub 1881380901 LKAYTEVkTVTIKVP molecular association, regulation transcription, inhibited ALDH1B1(DISRUPTS) 34769507 1 0 0 AMBRA1-mediated ubiquitylation of ALDH1B1 inhibitss the self-association of ALDH1B1 and the transcription of PTEN -SIAH1 SIAH1 Apoptosis; Cell development/differentiation; EC 6.3.2.-; EC 6.3.2.19; Ligase; Motility/polarity/chemotaxis; UBIQUITIN LIGASE; Ubiquitin conjugating system; Ubiquitin ligase Q8IUQ4 6477 16q12.1 human T239-p 36694105 RRLTWEAtPRSIHEG Sina molecular association, regulation; acetylation; intracellular localization signaling pathway regulation GAPDH(INDUCES) 25391652 1 0 0 augments p300 acetylation; nuclear translocation -H3C1 H3 DNA-binding P68431 8350 6p22.2 human T3-p 455678 _____ARtKQTARKS Histone molecular association, regulation; enzymatic activity, inhibited; intracellular localization cell cycle regulation; chromatin organization, altered; cytoskeletal reorganization; transcription, inhibited; signaling pathway regulation TAF140(DISRUPTS); PHF21A(DISRUPTS); JMJD2A(DISRUPTS); ING2(DISRUPTS); RAG2(DISRUPTS); Survivin(INDUCES); AIRE(DISRUPTS) 15846065; 17084365; 17938195; 19187761; 20190764; 20705812; 20929775; 20953165; 21658950; 21820363 23 2 0 -Pou5f1 Oct4 DNA-binding; Transcription factor P20263 18999 17 B1|17 18.69 cM mouse K133-ub 15395132 PEESQDMkALQKELE protein degradation 32895487 1 0 1 -CD19 CD19 Cell surface; Membrane protein, integral P15391 930 16p11.2 human Y500-p 447638 TSLGSQSyEDMRGIL molecular association, regulation LYN(INDUCES); PIK3CA(INDUCES); VAV1(INDUCES) 10933394 6 4 15 -WWTR1 TAZ Oncoprotein; Transcription, coactivator/corepressor Q9GZV5 25937 3q25.1 human T346-p 41594202 TGENAGQtPMNINPQ protein degradation; activity, inhibited carcinogenesis, inhibited; cell growth, inhibited; cell motility, inhibited; transcription, inhibited 26183396; 26375055 2 0 0 -H3c1 H3 DNA-binding P68433 360198 13|13 A3.1 mouse K4-m2 459004 ____ARTkQTARKST Histone methylation cell differentiation, induced; chromatin organization, altered; transcription, induced; transcription, inhibited 16682010; 17488778; 17493269; 17967893; 18039862; 18927235; 19707598; 20067909; 20393567; 20395309; 20574709; 23362347; 29370269 108 10 0 -FLT3 FLT3 EC 2.7.10.1; KINASE; Kinase, protein; Membrane protein, integral; Oncoprotein; Protein kinase, TK; Protein kinase, tyrosine (receptor) P36888 2322 13q12.2 human R973-m2 1879733101 PHTYQNRrPFSREMD molecular association, regulation carcinogenesis, induced; cell growth, induced; apoptosis, inhibited GRB2(INDUCES); Btk(NOT_REPORTED); SHP-2(INDUCES) 31217189; 31395602 2 2 0 -Per2 PER2 Nuclear receptor co-regulator; Nucleolus; Transcription factor O54943 18627 1|1 D mouse S662-p 470017 GKAESVVsLTSQCSY phosphorylation 29784789 3 1 1 induces phosphorylation of S662 and further regulating the circadian clock -CDC25A CDC25A EC 3.1.3.48; Motility/polarity/chemotaxis; PHOSPHATASE; Protein phosphatase, dual-specificity P30304 993 3p21.31 human S107-p 31086927 NPMRRIHsLPQKLLG M-inducer_phosp protein degradation; ubiquitination cell cycle regulation; apoptosis, inhibited 34363019 1 3 0 -Hoxb9 HOXB9 DNA-binding P20615 15417 11 D|11 59.81 cM mouse T133-p 31087958 GELLKQGtPEYSLET Hox9_act protein degradation; ubiquitination carcinogenesis, inhibited; cell motility, inhibited; transcription, inhibited; signaling pathway regulation 36001969 1 2 0 regulates the AMPK-HOXB9-KRAS pathway -Slc12a5 KCC2 iso2 Membrane protein, integral; Membrane protein, multi-pass; Transporter; Transporter, SLC family Q91V14-2 57138 2|2 H3 mouse S940-p 487533 ITDESRGsIRRKNPA SLC12 activity, induced; protein stabilization neural plasticity; endocytosis, inhibited 21532577; 22171026; 25546454; 25733865; 31396048; 31806759; 32427585 23 5 2 -DGCR8 DGCR8 Nucleolus; RNA processing; RNA-binding Q8WYQ5 54487 22q11.21 human S377-p 3208083 LTPSGDVsPVKPLSR protein stabilization 24239349 1 43 4 -CLOCK CLOCK ACETYLTRANSFERASE; Acetyltransferase; DNA-binding; EC 2.3.1.48; Transcription factor O15516 9575 4q12 human S434-p 12059703 SPTPSASsRSSRKSS protein degradation 19946213 1 0 0 -IL16 IL16 Cytokine; DNA-binding; Motility/polarity/chemotaxis Q14005 3603 15q25.1 human T757-p 11280303 TQGHPDGtPPKLDTA intracellular localization cell cycle regulation 12450396 1 0 0 regulate nuclear localization -SLC6A4 SERT Membrane protein, integral; Membrane protein, multi-pass; Transporter P31645 6532 17q11.2 human Y47-p 21697923 SGQISNGySAVPSPG 5HT_transport_N activity, induced; protein stabilization 21992875 1 0 1 increases 5-HT uptake -FOXO4 FOXO4 DNA-binding; Oncoprotein; Transcription factor P98177 4303 Xq13.1 human T32-p 455572 QSRPRSCtWPLPRPE intracellular localization transcription, inhibited 16272144 6 8 34 -CD79A Ig-alpha Immunoglobulin superfamily; Membrane protein, integral P11912 973 19q13.2 human Y210-p 447752 SRGLQGTyQDVGSLN molecular association, regulation NCK1(INDUCES) 23913047 6 5 30 Akt activation -TPD52 TPD52 Calcium-binding; Endoplasmic reticulum P55327 7163 8q21.13 human S40-p 17555377 GNSSPPGsPTLQKFG protein stabilization; molecular association, regulation carcinogenesis, induced; cell motility, induced; cell growth, induced SPOP(DISRUPTS) 35194188 1 3 0 inhibits ubiquitination -NLRP3 NLRP3 Inhibitor Q96P20 114548 1q44 human S806-p 1877558200 KLVELDLsDNALGDF LRR_6 molecular association, regulation NEK7(DISRUPTS); BRCC3(DISRUPTS) 34615873 1 1 0 induces deubiquitination -SCNN1B ENaC-beta Channel, sodium; Membrane protein, integral; Membrane protein, multi-pass; Transporter, ion channel P51168 6338 16p12.2 human T615-p 451219 QALPIPGtPPPNYDS ubiquitination endocytosis, induced 28588583 6 1 0 -NCAPH2 NCAPH2 Cell cycle regulation; Endoplasmic reticulum; Membrane protein, integral Q6IBW4 29781 22q13.33 human S288-p 36136891 ESRSPQQsAALPRRY cell cycle regulation 28717250 1 1 0 required for mitotic chromosome segregation -NFE2L2 NRF2 DNA-binding; Transcription factor Q16236 4780 2q31.2 human K445-ac 7106316 KTPFTKDkHSSRLEA molecular association, regulation transcription, induced DNA(INDUCES) 19273602 1 1 0 -CDKN2A p16-INK4A Cell cycle regulation; Nucleolus; Tumor suppressor P42771 1029 9p21.3 human S7-p 448829 _MEPAAGsSMEPSAD protein stabilization 21270107 3 0 0 -Dpysl2 CRMP-2 Microtubule-binding; Motility/polarity/chemotaxis P47942 25416 15p12 rat K374-sm 31094501 DKAVVTGkMDENQFV Amidohydro_1 sumoylation endocytosis, induced 27940916 6 0 0 -RACK1 RACK1 Adaptor/scaffold; G protein; G protein, heterotrimeric; G protein, heterotrimeric beta; Motility/polarity/chemotaxis; Nuclear receptor co-regulator P63244 10399 5q35.3 human S146-p 999602 KYTVQDEsHSEWVSC WD40 protein conformation 17965024 1 0 0 S146 phosphoirylation promotes dimerization of RACK1 and degredation of HIF-1 alpha. -PDGFRA PDGFRA EC 2.7.10.1; KINASE; Kinase, protein; Membrane protein, integral; Oncoprotein; Protein kinase, TK; Protein kinase, tyrosine (receptor) P16234 5156 4q12 human Y572-p 448437 ISPDGHEyIYVDPMQ molecular association, regulation Src(INDUCES) 9454734 2 6 16 -SHC3 SHC3 Adaptor/scaffold; Motility/polarity/chemotaxis Q92529 53358 9q22.1 human Y341-p 451254 GDGSDHPyYNSIPSK apoptosis, inhibited 12242309 3 1 3 -PCBP2 hnRNP E2 RNA splicing; RNA-binding Q15366 5094 12q13.13 human S272-p 482918 FSGIESSsPEVKGYW protein stabilization; molecular association, regulation cell differentiation, inhibited; translation, inhibited RNA(INDUCES) 17475908 1 19 8 -LATS1 LATS1 EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, AGC; Protein kinase, Ser/Thr (non-receptor); Tumor suppressor O95835 9113 6q25.1 human S909-p 457594 HQRCLAHsLVGTPNY Pkinase protein degradation; intracellular localization; phosphorylation; enzymatic activity, induced cell cycle regulation; carcinogenesis, induced; carcinogenesis, inhibited; apoptosis, induced; cell growth, inhibited; signaling pathway regulation; cell growth, induced; transcription, inhibited 15688006; 29934311; 31239271; 35307353; 35731019; 35882980; 36115593; 36622276; 37319316 32 5 15 -XBP1 XBP1 DNA-binding; Transcription factor P17861 7494 22q12.1|22q12 human K60-ub 1878023502 GGLPQARkRQRLTHL protein degradation; ubiquitination; intracellular localization transcription, inhibited 31837300 1 0 0 K60/77R enhances the nuclear localization, enhances insulin sensitivity in the hepatocyte and in db/db mice, maintains glucose homeostasis in DIO mice, alleviates ER stress in DIO mice, increases its protein abundance, transcriptional activity -FLT1 VEGFR1 EC 2.7.10.1; KINASE; Kinase, protein; Membrane protein, integral; Protein kinase, TK; Protein kinase, tyrosine (receptor) P17948 2321 13q12.3 human K831-me 4061500 RERLKLGkSLGRGAF PK_Tyr_Ser-Thr phosphorylation; enzymatic activity, induced 18006819 1 0 0 enhances VEGFR1 autophosphorylation -TFAM TFAM DNA-binding; Transcription regulation Q00059 7019 10q21.1 human K52-ac 1876567508 VLASCPKkPVSSYLR HMG_box transcription, induced 35278431 0 1 0 -SPIN1 SPIN1 DNA-binding; Nucleolus Q9Y657 10927 9q22.1 human T120-p 471338 VLPDRVAtSRISDAH protein stabilization; protein conformation cell cycle regulation 17082182 1 0 0 -Syn1 SYN1 Vesicle P09951 24949 Xq11 rat S62-p 451572 STAAPVAsPAAPSPG neural plasticity; signaling pathway regulation 31493733; 33519375; 35723394 20 9 0 -Sstr2 SSTR2 GPCR, family 1; Membrane protein, integral; Membrane protein, multi-pass; Receptor, GPCR P30875 20606 11 E2|11 79.05 cM mouse Y312-p 450820 SCANPILyAFLSDNF 7tm_1 molecular association, regulation SHP-2(INDUCES) 12972574 1 0 0 -ELAVL1 HuR RNA-binding Q15717 1994 19p13.2 human K326-ub 31006100 FKTNKSHk_______ molecular association, regulation RNA stability, inhibited ETEA(INDUCES) RNA(DISRUPTS) 23618873 1 0 0 -FOXO3 FOXO3A Autophagy; DNA-binding; Oncoprotein; Transcription factor O43524 2309 6q21 human S7-p 9318032 _MAEAPAsPAPLSPL activity, induced; intracellular localization; phosphorylation cell cycle regulation 22128155; 26376801 2 22 19 -CAMKK1 CAMKK1 EC 2.7.11.17; KINASE; Kinase, protein; Protein kinase, Other; Protein kinase, Ser/Thr (non-receptor) Q8N5S9 84254 17p13.2 human S74-p 452115 SLSARKLsLQERPAG molecular association, regulation; enzymatic activity, inhibited; enzymatic activity, induced 14-3-3 eta(INDUCES) 11574071; 18242179 4 19 8 14-3-3 inhibits CAMKK1 activity. ; activity toward PKIV peptide; replacement of S74 to A or D caused an increase in the enzyme activity -FLT1 VEGFR1 EC 2.7.10.1; KINASE; Kinase, protein; Membrane protein, integral; Protein kinase, TK; Protein kinase, tyrosine (receptor) P17948 2321 13q12.3 human Y1213-p 448209 GSSDDVRyVNAFKFM molecular association, regulation; enzymatic activity, induced GRB2(INDUCES); PLCG1(INDUCES); SHP-2(INDUCES) 11583921; 9722576 4 0 7 -Bcar1 P130Cas Adaptor/scaffold; Motility/polarity/chemotaxis Q63767 25414 19q12 rat Y347-p 448721 APGSQDIyDVPPVRG cell motility, altered 12972425 14 44 723 -KLF11 TIEG2 C2H2-type zinc finger protein; DNA-binding; Transcription factor O14901 8462 2p25.1 human S111-p 456009 LCITPPQsPDLVEPS molecular association, regulation SIN3A(DISRUPTS) 12006497 1 1 0 -MCL1 MCL1 Apoptosis; Channel, misc.; Inhibitor; Membrane protein, integral; Mitochondrial Q07820 4170 1q21.2 human K197-ub 10837359 ATGAKDTkPMGRSGA protein degradation 28522751 4 5 27 -SLC25A5 SLC25A5 Membrane protein, integral; Membrane protein, multi-pass; Mitochondrial; Transporter; Transporter, SLC family P05141 292 Xq24 human K105-ac 461136 IFLGGVDkRTQFWLY protein degradation; phosphorylation 32194820 1 9 107 reciprocal regulation of T107, K105 -Fzd3 FZD3 GPCR, Fz/Smo family; Membrane protein, integral; Membrane protein, multi-pass; Receptor, GPCR Q61086 14365 14 D1|14 34.09 cM mouse T563-p 18507001 TSTHASStQLAMVDD receptor internalization, inhibited; phosphorylation endocytosis, inhibited 21316586 1 0 0 enhances PCP signaling, regulating c-Jun phosphorylation, and affecting growth cone guidance -EIF2B5 eIF2B-epsilon Translation; Translation initiation Q13144 8893 3q27.1 human S540-p 449905 MDSEEPDsRGGSPQM signaling pathway regulation; translation, inhibited 22231169 10 3 0 -CCNF CCNF Cell cycle regulation P41002 899 16p13.3 human S577-p 234613503 TKRKRENsLQEDRGS protein stabilization cell cycle regulation 28954236 2 2 0 cell-cycle progression -UCK1 UCK1 EC 2.7.1.48; Kinase, other; Nucleotide Metabolism - pyrimidine; Xenobiotic Metabolism - drug metabolism - other enzymes Q9HA47 83549 9q34.13 human K81-ub 27213910 EQKAKALkGQYNFDH PRK protein degradation 31938050 1 5 0 -HSP90AB1 HSP90B Chaperone; Heat shock protein P08238 3326 6p21.1 human K286-ac 36304638 QEELNKTkPIWTRNP HSP90 molecular association, regulation; intracellular localization; activity, inhibited transcription, induced; signaling pathway regulation HIF1A(DISRUPTS); HIF2A(DISRUPTS) 28915577 1 1 0 HIF signaling -PPP2R2B PPP2R2B iso2 Apoptosis; Mitochondrial; Motility/polarity/chemotaxis; Protein phosphatase, regulatory subunit Q00005-2 5521 5q32 human S20-p 25554903 RPPNTILsSSCHTEA intracellular localization; phosphorylation apoptosis, inhibited 22583914 1 0 0 induces phosphorylation of Drp1 and regulates mitochondrial fragmentation and OMM translocation of beta B2 -PRKG1 PKG1 EC 2.7.11.12; KINASE; Kinase, protein; Protein kinase, AGC; Protein kinase, Ser/Thr (non-receptor) Q13976 5592 10q11.23-q21.1 human T59-p 1870119330 THIGPRTtRAQGISA enzymatic activity, induced 12609995 1 0 0 -POLG POLG DNA repair, damage; DNA replication; EC 2.7.7.7; Mitochondrial; Transferase P54098 5428 15q26.1 human K1060-ub 21181880 TESEMFNkLESIATS DNA_pol_A protein degradation; molecular association, regulation; intracellular localization; enzymatic activity, inhibited TOM20(DISRUPTS) 33657094 1 2 0 ubiquitylated POLG cannot enter mitochondria -TPT1 TPT1 Calcium-binding; Microtubule-binding P13693 7178 13q14.13 human K19-ac 33348800 EMFSDIYkIREIADG TCTP protein degradation HSC70(INDUCES) 28110910 1 2 0 -GRK2 GRK2 EC 2.7.11.15; KINASE; Kinase, protein; Protein kinase, AGC; Protein kinase, Ser/Thr (non-receptor) P25098 156 11q13.2 human S670-p 447725 KMKNKPRsPVVELSK protein degradation; acetylation; molecular association, regulation; ubiquitination; phosphorylation cell cycle regulation; chromatin organization, altered; cell motility, induced; cell adhesion, induced; cytoskeletal reorganization; cell growth, altered PIN1(INDUCES) 20080565; 22193721; 33806062 5 40 18 induces deacetylation of TUBA1A at K40 via HDAC6 phosphorylation; induces MST2 phosphorylation -Eef1a1 EEF1A1 Nucleolus; Translation; Translation elongation P62630 171361 8q31 rat K165-m2 3898709 TEPPYSQkRYEEIVK GTP_EFTU molecular association, regulation translation, altered EEF1D(DISRUPTS); eEF1B(DISRUPTS); EEF1G(DISRUPTS) 28108655 1 7 12 -WIPF1 WIPF1 Actin-binding; Motility/polarity/chemotaxis O43516 7456 2q31.1 human T398-p 14582886 TSRALPAtPQLPSRS cell growth, induced 28166194 1 12 7 -IRF3 IRF3 DNA-binding; Transcription factor Q14653 3661 19q13.33 human K366-m1 1873286920 TKRLVMVkVVPTCLR IRF-3 molecular association, regulation; phosphorylation transcription, induced PPP1CC(DISRUPTS) 29101251 1 1 0 induces antiviral innate immune response -STK38 NDR1 EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, AGC; Protein kinase, Ser/Thr (non-receptor) Q15208 11329 6p21.31 human S11-p 22553320 TGSTPCSsMSNHTKE enzymatic activity, inhibited; phosphorylation signaling pathway regulation 22142472 1 0 0 primes phosphorylation at S6 and T7, induces JNK phosphorylation, regulates cell death through JNK signaling -Ptpn2 PTPN2 EC 3.1.3.48; Motility/polarity/chemotaxis; PHOSPHATASE; Protein phosphatase, tyrosine (non-receptor) Q06180 19255 18|18 E1 mouse T179-p 397383601 ISHFHYTtWPDFGVP Y_phosphatase molecular association, regulation; intracellular localization apoptosis, induced STAT3(INDUCES) 29207596 1 1 0 nuclear translocation -Ahcyl1 AHCYL1 Amino Acid Metabolism - cysteine and methionine; EC 3.3.1.1; Hydrolase; Other Amino Acids Metabolism - selenoamino acid Q80SW1 229709 3 F2.3|3 46.83 cM mouse S70-p 467247 LSRSISQsSTDSYSS molecular association, regulation PIP5K1A(INDUCES); IP3R1(INDUCES) 16793548; 26509711 2 0 0 -Camsap1 CAMSAP1 Unknown function A2AHC3 227634 2|2 A3 mouse S1464-p 1869962002 PIIHNAIsHCCLAGK CAMSAP_CKK cell differentiation, induced; cytoskeletal reorganization 32839317 1 1 0 -Neurod1 NEUROD1 DNA-binding; Transcription factor Q60867 18012 2 C3|2 47.58 cM mouse S162-p 465677 EILRSGKsPDLVSFV Neuro_bHLH transcription, induced 12810726 1 0 0 -TUT1 RBM21 EC 2.7.7.19; EC 2.7.7.52; Nucleolus; Transferase Q9H6E5 64852 11q12.3 human S6-p 31080908 __MAAVDsDVESLPR molecular association, regulation transcription, induced; translation, induced RBM21(INDUCES) RNA(INDUCES) 26138484; 29203642 2 6 0 CDH1, CDH13, KISS1R, NME1, WIF1 wound healing -HTT Huntingtin Cytoskeletal P42858 3064 4p16.3 human S429-p 2020877 ELIAGGGsSCSPVLS protein degradation 22623107 2 9 2 increased cell viability and reduced protein accumulation in S429A mutant -TCF3 E2A Cell development/differentiation; DNA-binding; Oncoprotein; Transcription factor P15923 6929 19p13.3 human K34-ac 25218500 PLPVTNGkGRPASLA molecular association, regulation transcription, induced p300(INDUCES); CBP(INDUCES) 22207202 1 0 0 -TP53 p53 Activator; DNA-binding; Motility/polarity/chemotaxis; Nuclear receptor co-regulator; Transcription factor; Tumor suppressor P04637 7157 17p13.1 human R333-me 5009203 EYFTLQIrGRERFEM P53_tetramer cell cycle regulation; apoptosis, inhibited; transcription, altered 53BP1(INDUCES) 19011621 1 1 0 PRMT5 enhanced p53-dependent cell-cycle arrest; after treatment with PRMT5 theere was a reduction in dimer and tetramer formation; arginine methylation affects the promoter specificity of p53 -LAIR1 LAIR-1 Membrane protein, integral; Receptor, misc. Q6GTX8 3903 19q13.42 human Y281-p 449313 PMAESITyAAVARH_ molecular association, regulation SHP-1(INDUCES) 10764762 2 6 332 -Maf MAF Cell development/differentiation; DNA-binding; Oncoprotein; Transcription factor; Tumor suppressor P54843 17132 8 E1|8 62.61 cM mouse Y131-p 25673103 LQGGFDGyARGAQQL molecular association, regulation transcription, induced DNA(INDUCES) 25993510 2 0 0 IL-4 and IL-21 induction -NR3C1 GR DNA-binding; Mitochondrial; Nuclear receptor; Transcription factor P04150 2908 5q31.3 human K293-sm 2532300 LCTPGVIkQEKLGTV GCR protein degradation transcription, induced; transcription, inhibited 12144530; 12193561; 26712006 7 3 0 -Slc12a5 KCC2 iso2 Membrane protein, integral; Membrane protein, multi-pass; Transporter; Transporter, SLC family Q63633-2 171373 3q42 rat T934-p 33623802 EREIQSItDESRGSI SLC12 activity, induced; protein conformation 24849604 3 0 0 increase transport kinetics of KCC2 -Ankrd54 ANKRD54 Cell cycle regulation Q91WK7 223690 15 E1|15 37.7 cM mouse S14-p 239773904 GADDESRsGRSSSDG molecular association, regulation; intracellular localization LYN(INDUCES) 28924458 1 1 0 nuclear export, cytoplasmic accumulation -Cacna1c CACNA1C Channel, calcium; Membrane protein, integral; Membrane protein, multi-pass P22002 24239 4q42 rat Y2148-p 450658 PEDESCVyALGRGRS activity, induced; molecular association, regulation ITGB1(INDUCES) 10939336; 16554304; 21178109 3 0 0 -SP1 SP1 C2H2-type zinc finger protein; DNA-binding; Transcription factor P08047 6667 12q13.13 human K703-ac 12718501 MRSDHLSkHIKTHQN zf-C2H2 molecular association, regulation; acetylation transcription, inhibited p300(DISRUPTS) 16478997 3 0 0 inhibits acetylation of histone 3 by inhibiting recruitiment of p300 to the promoter -GHR GH receptor Membrane protein, integral; Receptor, cytokine P19941 100009325 rabbit Y595-p 450480 SEMPVPDyTSIHLVQ GHBP molecular association, regulation SOCS2(INDUCES); CISH(INDUCES) 17666591 3 1 0 -Kmt2a MLL Cell cycle regulation; EC 2.1.1.43; METHYLTRANSFERASE; Methyltransferase; Methyltransferase, protein lysine; Oncoprotein; Transcription factor P55200 214162 9 A5.2|9 24.84 cM mouse K1130-ac 40493901 APPIKPIkPVTRNKA transcription, induced 25751424 1 0 0 -Lipe HSL EC 3.1.1.79; Lipase P15304 25330 1q21 rat S863-p 448803 LTESMRRsVSEAALA enzymatic activity, induced transcription, induced 28716938; 9636039 41 11 2 regulation of steroidogenesis -Tnni3 TNNI3 Actin-binding; Motility/polarity/chemotaxis; Motor P48787 21954 7 A1|7 2.61 cM mouse T144-p 451483 RGKFKRPtLRRVRIS Troponin activity, induced; activity, inhibited; protein conformation; phosphorylation cytoskeletal reorganization; signaling pathway regulation 12923217; 15774859; 17010989; 19426736; 22527640; 24772522 29 2 1 regulates contractibility of cardiac myocytes; ROCK II induced desensitization to Ca++ and depression in maximal tension. -MZF1 MZF-1 C2H2-type zinc finger protein; DNA-binding; Transcription factor P28698 7593 19q13.43 human S27-p 50784428 VMVKLEDsEEEGEAA activity, induced; molecular association, regulation carcinogenesis, induced; transcription, induced; signaling pathway regulation CTCF(DISRUPTS) 30622337 1 3 0 -Mcm4 MCM4 DNA replication; EC 3.6.4.12 P49717 17217 16 A2|16 10.09 cM mouse T19-p 448634 SSRRGRVtPTQSLRS activity, inhibited 11454864 3 21 16 Phosphorylation of T19 correlates with lowered level of DNA helicase activity of the purified Mcm4,6,7 complex. -RIGI RIGI EC 3.6.4.13; Hydrolase O95786 23586 9p21.1 human T170-p 12613700 DKENWPKtLKLALEK CARD_2 molecular association, regulation; ubiquitination; protein conformation transcription, induced; transcription, inhibited NPL4(DISRUPTS); TRIM25(DISRUPTS); MAVS(DISRUPTS) 20071582; 22114345; 23063562; 23264040; 26471729; 28250012 9 1 0 -P2RX3 P2X3 Channel, ligand-gated; Membrane protein, integral; Membrane protein, multi-pass P56373 5024 11q12.1 human S269-p 458894 FTRLDSVsEKSSVSP P2X_receptor receptor desensitization, altered 16226373 1 0 0 -AKAP12 AKAP12 Adaptor/scaffold Q02952 9590 6q25.1 human S698-p 455890 RARRGSSsDEEGGPK receptor desensitization, inhibited; molecular association, regulation ADRB2(INDUCES) 14657015 1 20 35 -Cacnb2 CACNB2 Channel, calcium Q8VGC3 116600 17q12.3 rat T549-p 470081 RGLSRQEtFDSETQE activity, induced 16949361 5 8 30 increases the probability of channel being open (facilitation) -Gabbr2 GABBR2 GPCR, family 3; Membrane protein, integral; Membrane protein, multi-pass; Receptor, GPCR Q80T41 242425 4|4 B1 mouse S892-p 450809 EHIQRRLsLQLPILH receptor desensitization, inhibited; molecular association, regulation; protein conformation; phosphorylation KCTD12(INDUCES) 25065880 6 1 0 Binding of KCTD12 to GABBR2 increases S892 phosphorylation. -Pklr PKLR iso2 Carbohydrate Metabolism - glycolysis and gluconeogenesis; Carbohydrate Metabolism - pyruvate; EC 2.7.1.40; Kinase, other; Nucleotide Metabolism - purine P12928-2 24651 2q34 rat S113-p 31084572 ATESFATsPLSYRPV PK intracellular localization 31825824 1 2 0 suppresses glucose production -TNNI3 TNNI3 Actin-binding; Motility/polarity/chemotaxis; Motor P19429 7137 19q13.42 human T143-p 451483 RGKFKRPtLRRVRIS Troponin activity, induced; molecular association, regulation; activity, inhibited; protein conformation TNNC1(DISRUPTS); C16orf82(INDUCES); TNC(INDUCES) 12044157; 18986304; 24116014; 24585778 29 2 1 reduced maximal force generation; induces Ca2+ sensitivity myofilaments without affecting LDA -KATNA1 KATNA1 EC 3.6.4.3; Hydrolase; Motility/polarity/chemotaxis O75449 11104 6q25.1 human T133-p 26401201 HGNRPSTtVRVHRSS ubiquitination cell cycle regulation 19287380 1 0 0 -Mapk7 ERK5 EC 2.7.11.24; KINASE; Kinase, protein; Protein kinase, CMGC; Protein kinase, Ser/Thr (non-receptor) Q9WVS8 23939 11|11 B2 mouse S486-p 450251 LKAALLKsLRSRLRD molecular association, regulation; enzymatic activity, inhibited 14-3-3 beta(INDUCES) 14679215 2 4 0 -HSPA5 GRP78 Chaperone; Heat shock protein; KINASE P11021 3309 9q33.3 human K352-ac 3284874 VLEDSDLkKSDIDEI HSP70 molecular association, regulation; phosphorylation apoptosis, induced; signaling pathway regulation PERK(DISRUPTS) 20371724 1 1 3 induces phosphorylation of elf2a and activation of eIf2a-ATF4-CHOP pathway -Rela NFkB-p65 DNA-binding; Nuclear receptor co-regulator; Transcription factor Q04207 19697 19 A|19 4.34 cM mouse K122-ac 458970 NLGIQCVkKRDLEQA RHD_DNA_bind activity, induced; intracellular localization; phosphorylation cell differentiation, induced; transcription, induced; transcription, inhibited; transcription, altered; signaling pathway regulation 25672970; 26391411; 27381458 6 2 24 -PDGFRB PDGFRB EC 2.7.10.1; KINASE; Kinase, protein; Membrane protein, integral; Oncoprotein; Protein kinase, TK; Protein kinase, tyrosine (receptor) P09619 5159 5q32 human Y763-p 448850 DMKGDVKyADIESSN PK_Tyr_Ser-Thr molecular association, regulation SHP-2(INDUCES) 10391677; 11896619; 17403678 6 1 2 -HK2 HK2 Carbohydrate Metabolism - amino sugar and nucleotide sugar; Carbohydrate Metabolism - fructose and mannose; Carbohydrate Metabolism - galactose; Carbohydrate Metabolism - glycolysis and gluconeogenesis; Carbohydrate Metabolism - starch and sucrose; EC 2.7.1.1; Kinase, other; Mitochondrial P52789 3099 2p12 human Y686-p 62906106 GTGSNACyMEEMRNV Hexokinase_2 cell motility, induced 28054552 1 1 0 promote cell migration and invasion -Etv1 ETV1 DNA-binding; Oncoprotein; Transcription factor P41164 14009 12 A3|12 17.99 cM mouse T143-p 3059604 NPPTPSStPVSPLHH ETS_PEA3_N activity, induced transcription, induced; signaling pathway regulation 22586091 2 0 0 -LRP6 LRP6 Membrane protein, integral; Receptor, misc. O75581 4040 12p13.2 human S1490-p 456289 AILNPPPsPATERSH activity, induced; molecular association, regulation; phosphorylation cell cycle regulation; carcinogenesis, induced; cell growth, induced; transcription, induced; signaling pathway regulation; transcription, altered axin 1(INDUCES); caveolin-1(INDUCES) 14731402; 16341017; 16890161; 21887268; 22558232; 25500543; 25735981; 27821587; 34615853; 35277657; 35487243; 35637196 32 13 55 induces WNT signaling; Wnt signaling; induces the Wnt/?-catenin signalling pathway; induces Wnt/?-catenin signaling pathway -Arhgef7 ARHGEF7 GEF; GEF, Rac/Rho; Motility/polarity/chemotaxis Q9ES28 54126 8|8 A1.1 mouse Y755-p 1443172900 DLSEDSEyDSIWTAH activity, induced; molecular association, regulation neural plasticity; cytoskeletal reorganization GluR2(INDUCES) 30683798 1 0 0 -SUPT5H SPT5 RNA-binding; Transcription, coactivator/corepressor O00267 6829 19q13.2 human T768-p 458814 MTSTYGRtPMYGSQT transcription, altered 16427012 1 0 13 required for c-fos induction and activation in vivo -GP1BA GPIbA Cell adhesion; Cell surface; Membrane protein, integral P07359 2811 17p13.2 human S632-p 1983279 GRRPSALsQGRGQDL molecular association, regulation cytoskeletal reorganization 14-3-3 sigma(INDUCES); 14-3-3 zeta(INDUCES); PIK3R1(INDUCES) 15054037; 18299448; 19874472 3 10 19 cell spreading (not adhering efficiency) -ISL1 ISL1 Cell development/differentiation; DNA-binding; Motility/polarity/chemotaxis; Nuclear receptor co-regulator; Transcription factor P61371 3670 5q11.1 human S269-p 515814094 GTPMVAAsPERHDGG protein stabilization; molecular association, regulation; ubiquitination cell cycle regulation; carcinogenesis, induced; cell differentiation, induced; cell growth, induced; transcription, induced DNA(INDUCES) 33962568; 34329593 2 1 0 inhibits ubiquitination -Ntrk2 TrkB EC 2.7.10.1; KINASE; Kinase, protein; Membrane protein, integral; Protein kinase, TK; Protein kinase, tyrosine (receptor) P15209 18212 13 B1|13 31.2 cM mouse Y816-p 451754 LAKASPVyLDILG__ receptor internalization, induced; molecular association, regulation; intracellular localization; phosphorylation; enzymatic activity, induced neural plasticity; apoptosis, inhibited; transcription, induced; signaling pathway regulation PLCG1(INDUCES); AP2M1(INDUCES) 21543608; 27680698; 31004063; 32358047; 32427585; 34343610; 36682419 20 0 0 -Bach2 BACH2 DNA-binding; Transcription factor P97303 12014 4|4 A5 mouse S535-p 25731482 AEDGSGGsPCSLPLC protein degradation; intracellular localization; activity, inhibited transcription, induced 26620562; 28993481 2 1 2 cytoplasmic localization; increased repressor activity of Bach2 S509A and Bach2 S535A mutants was observed -NFYA NFYA DNA-binding; Transcription factor P23511 4800 6p21.1 human S326-p 3182071 FSPKEKDsPHMQDPN intracellular localization cell cycle regulation; transcription, induced 30589568 1 32 2 -FUS hnRNP P2 DNA-binding; Nuclear receptor co-regulator; Oncoprotein; RNA splicing; RNA-binding; SUMO LIGASE P35637 2521 16p11.2 human R522-me 1873375606 GEHRQDRrERPY___ intracellular localization KPNB2(DISRUPTS) 22968170 1 0 0 Arginines in the RGG3 domain are required for nuclear import of mutant hnRNP, and arginine methylation in this domain reduces KPNB2 binding. -DRD2 DRD2 GPCR, family 1; Membrane protein, integral; Membrane protein, multi-pass; Receptor, GPCR P14416 1813 11q23.2 human T225-p 13270200 RRRKRVNtKRSSRAF 7tm_1 receptor internalization, altered 20160122 2 0 0 -Aqp4 AQP4 Channel, misc.; Membrane protein, integral; Membrane protein, multi-pass; Transporter; Transporter, aquaporin family P47863 25293 18p13 rat S276-p 465556 AAQQTKGsYMEVEDN protein degradation; molecular association, regulation; intracellular localization AP3M1(INDUCES) 11742978 2 6 0 -Mapt Tau ACETYLTRANSFERASE; Acetyltransferase; Cytoskeletal P19332 29477 10q32.1 rat S667-p 449104 RVQSKIGsLDNITHV Tubulin-binding cytoskeletal reorganization 18245083 35 24 0 -Raf1 RAF1 EC 2.7.11.1; KINASE; Kinase, protein; Oncoprotein; Protein kinase, Ser/Thr (non-receptor); Protein kinase, TKL Q99N57 110157 6 E3|6 53.62 cM mouse S338-p 447742 RPRGQRDsSYYWEIE activity, induced; molecular association, regulation; phosphorylation; enzymatic activity, induced carcinogenesis, induced; cell motility, induced; cell growth, induced; apoptosis, inhibited; signaling pathway regulation RAF1(DISRUPTS); RASA1(DISRUPTS); ROCK2(INDUCES) 10205168; 15026317; 15899852; 22169110; 22388104; 23993095; 28270557; 31312020 92 2 7 -CHUK IKKA EC 2.7.11.10; KINASE; Kinase, protein; Protein kinase, Other; Protein kinase, Ser/Thr (non-receptor) O15111 1147 10q24.31 human S176-p 447778 AKDVDQGsLCTSFVG Pkinase enzymatic activity, induced transcription, induced; signaling pathway regulation 33883226; 34017102; 9520446 34 1 0 TRIM26 enhances TLRs-induced NF-kB and MAPK signaling. -DRD2 DRD2 GPCR, family 1; Membrane protein, integral; Membrane protein, multi-pass; Receptor, GPCR P14416 1813 11q23.2 human K221-ub 1877221606 IVLRRRRkRVNTKRS 7tm_1 protein degradation 32572597 1 0 0 -RBL2 Rb-like 2 Transcription, coactivator/corepressor; Tumor suppressor Q08999 5934 16q12.2 human S1068-p 449740 HKNETMLsPREKIFY molecular association, regulation cell cycle regulation E2F4(DISRUPTS) 11157749 2 13 11 -FOXO3 FOXO3A Autophagy; DNA-binding; Oncoprotein; Transcription factor O43524 2309 6q21 human S318-p 453423 SRTNSNAsTVSGRLS activity, induced; intracellular localization cell cycle regulation; transcription, inhibited SMAD4(INDUCES); SMAD3(INDUCES) 21532621; 33828192; 35077510 11 0 1 -HDAC1 HDAC1 DEACETYLASE; Deacetylase; EC 3.5.1.98; Hydrolase; Nuclear receptor co-regulator Q13547 3065 1p35.2-p35.1 human K74-ub 15389913 YHSDDYIkFLRSIRP Hist_deacetyl protein degradation 26832969 2 8 3 enhances vascular calcification -PABIR1 FAM122A Unknown function Q96E09 116224 9q21.11 human S37-p 3208890 GGLRRSNsAPLIHGL protein stabilization; molecular association, regulation; ubiquitination; intracellular localization; activity, inhibited; phosphorylation cell cycle regulation; carcinogenesis, induced; signaling pathway regulation 14-3-3 beta(INDUCES); PPP2CA(DISRUPTS) 33108758 2 35 124 induces WEE1 dephosphorylation and stabilization by inhibiting its ubiquitination, regulates the ATR-CHK1-WEE1 pathway -AKT1 Akt1 EC 2.7.11.1; KINASE; Kinase, protein; Oncoprotein; Protein kinase, AGC; Protein kinase, Ser/Thr (non-receptor) P31749 207 14q32.33 human S477-p 8086735 PQFSYSAsGTA____ molecular association, regulation; phosphorylation; enzymatic activity, induced cell cycle regulation; carcinogenesis, induced; cell growth, induced; apoptosis, inhibited Sin1(INDUCES) 24670654 2 5 2 primed for phosphorylation of S473 -Ppp2r5d PPP2R5D Motility/polarity/chemotaxis; PHOSPHATASE; Protein phosphatase, regulatory subunit Q7TNL5 21770 17 22.9 cM|17 C mouse S566-p 457390 KVLLRRKsELPQDVY enzymatic activity, induced 17301223; 20106966 7 53 347 -RAF1 RAF1 EC 2.7.11.1; KINASE; Kinase, protein; Oncoprotein; Protein kinase, Ser/Thr (non-receptor); Protein kinase, TKL P04049 5894 3p25.2 human S359-p 28070702 STRIGSGsFGTVYKG PK_Tyr_Ser-Thr enzymatic activity, inhibited 23680146 1 0 0 -Nfkbia IkB-alpha DNA-binding; Inhibitor Q9Z1E3 18035 12|12 C1 mouse K21-sm 2535907 EGPRDGLkKERLVDD protein stabilization 14613580 6 0 0 -Nr1i2 PXR DNA-binding; Nuclear receptor O54915 18171 16|16 B3 mouse S347-p 4668103 MQAISLFsPDRPGVV Hormone_recep molecular association, regulation apoptosis, inhibited; transcription, altered DNA(INDUCES) 32798464; 35609418 9 0 0 -INSR INSR EC 2.7.10.1; KINASE; Kinase, protein; Membrane protein, integral; Protein kinase, TK; Protein kinase, tyrosine (receptor) P06213 3643 19p13.2 human Y999-p 447685 YASSNPEyLSASDVF activity, induced; molecular association, regulation; receptor internalization, altered; phosphorylation; enzymatic activity, induced cell cycle regulation SOCS3(INDUCES) 10340378; 10821852; 10852715; 11325969; 1647198; 1658004; 7508445 25 0 0 IRS-1 and p52Shc phosphorylation, Ras activation; phosphorylation of pp185, activation of glycogen synthesis -RET Ret EC 2.7.10.1; KINASE; Kinase, protein; Membrane protein, integral; Oncoprotein; Protein kinase, TK; Protein kinase, tyrosine (receptor) P07949 5979 10q11.21 human S909-p 62373700 EDSYVKRsQGRIPVK PK_Tyr_Ser-Thr enzymatic activity, induced 28009299 1 0 0 Dual-speci?city kinase activity -CACNA1B CACNA1B Channel, calcium; Membrane protein, integral; Membrane protein, multi-pass Q00975 774 9q34.3 human T421-p 465546 DVLKRAAtKKSRNDL activity, inhibited 11053424 4 0 0 -POLH POLH DNA repair, damage; EC 2.7.7.7; Transferase Q9Y253 5429 6p21.1 human S687-p 4931282 QGKRNPKsPLACTNK protein stabilization; molecular association, regulation cell cycle regulation; DNA repair, altered PCNA(DISRUPTS) 26988343; 28934491 3 5 9 cell survival -Sqstm1 SQSTM1 Autophagy; Nuclear receptor co-regulator; Ubiquitin conjugating system Q64337 18412 11|11 B1.3 mouse T272-p 454787 RSRLTPTtPESSSTG cell cycle regulation; carcinogenesis, altered; transcription, induced; signaling pathway regulation 20974803; 33395605 9 80 278 Keap1-Nrf2 signaling; in Ras-transformed embryonic fibroblasts -Uhrf1 UHRF1 DNA-binding; EC 6.3.2.-; EC 6.3.2.19; Ligase; Transcription factor; UBIQUITIN LIGASE; Ubiquitin conjugating system; Ubiquitin ligase Q8VDF2 18140 17|17 D mouse S656-p 469962 STGPTLSsPRASKKS protein degradation; ubiquitination; intracellular localization cell differentiation, induced; transcription, induced 31515281 3 12 0 -SMAD1 SMAD1 DNA-binding; Transcription factor Q15797 4086 4q31.21 human S206-p 451175 SSSTYPHsPTSSDPG protein degradation; molecular association, regulation; ubiquitination; intracellular localization transcription, altered YAP1(INDUCES) 17289590; 19914168; 9335504 3 0 0 -ATP2A2 SERCA2 Cell adhesion; EC 3.6.3.8; Endoplasmic reticulum; Hydrolase; Membrane protein, integral; Membrane protein, multi-pass; Transporter; Transporter, ion channel P16615 488 12q24.11 human K460-ub 12336210 NVFDTELkGLSKIER Cation_ATPase protein degradation 35611810 1 6 13 SIGMAR1 interacts with Q615 site and mediates SERCA2 degradation -LHX3 LHX3 DNA-binding; Transcription factor Q9UBR4 8022 9q34.3 human Y227-p 455296 GRQRWGQyFRNMKRS activity, induced transcription, induced 15517599 1 0 0 no change in binding to DNA or to certain proteins (NLI, PIT1, or MRG1) -Mitf MITF iso8 DNA-binding; Oncoprotein; Transcription factor Q08874-8 17342 6 D3|6 45.05 cM mouse S173-p 467214 PGLTISNsCPANLPN molecular association, regulation; intracellular localization transcription, altered 14-3-3 zeta(INDUCES) 16822840 1 0 0 -HADHA HADHA ACETYLTRANSFERASE; Acetyltransferase; Amino Acid Metabolism - lysine degradation; Amino Acid Metabolism - tryptophan; Amino Acid Metabolism - valine, leucine and isoleucine degradation; Carbohydrate Metabolism - butanoate; Carbohydrate Metabolism - propanoate; EC 1.1.1.211; EC 4.2.1.17; Lipid Metabolism - fatty acid; Lipid Metabolism - fatty acid elongation in mitochondria; Lipid Metabolism - unsaturated fatty acid biosynthesis; Lyase; Mitochondrial; Other Amino Acids Metabolism - beta-alanine; Oxidoreductase; Secondary Metabolites Metabolism - limonene and pinene degradation P40939 3030 2p23.3 human Y271-p 1883585000 LVEKLTAyAMTIPFV intracellular localization 37424790 1 1 0 -RPL11 RPL11 Motility/polarity/chemotaxis; Nucleolus; Ribosomal; Translation P62913 6135 1p36.11 human K159-ne 12067608 GAKHRISkEEAMRWF Ribosomal_L5_C protein stabilization; intracellular localization 19713960 1 0 0 -Rangap1 RANGAP1 GAP; GAP, Ras P46061 19387 15 E1|15 38.21 cM mouse K526-sm 2251700 LIHMGLLkSEDKIKA RanGAP1_C sumoylation; intracellular localization 15931224; 9442102 11 12 0 -HDAC2 HDAC2 DEACETYLASE; Deacetylase; EC 3.5.1.98; Nuclear receptor co-regulator; Transcription, coactivator/corepressor Q92769 3066 6q21 human K51-sm 1877676805 LNYGLYRkMEIYRPH Hist_deacetyl acetylation; enzymatic activity, induced 30873037 1 0 0 inhibited IL-8 acetylation -EXOSC9 EXOSC9 EC 3.1.13.-; Nucleolus; RNA processing; Ribonuclease Q06265 5393 4q27 human S392-p 3194465 QDAPIILsDSEEEEM molecular association, regulation SUMO2(INDUCES); SUMO1(INDUCES) 19217413 1 18 1 -STK4 MST1 Autophagy; EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, STE; Protein kinase, Ser/Thr (non-receptor) Q13043 6789 20q13.12 human K35-ac 3847599 EVFDVLEkLGEGSYG Pkinase protein stabilization; molecular association, regulation carcinogenesis, inhibited HSC70(DISRUPTS) 26657153 1 0 1 -Pth1r PTHR GPCR, family 2; Membrane protein, integral; Membrane protein, multi-pass; Receptor, GPCR P25961 56813 8q32 rat S501-p 2853104 YSYGPMVsHTSVTNV receptor internalization, altered; activity, inhibited 11773434; 18577695 2 0 0 -Cacna1c CACNA1C Channel, calcium; Membrane protein, integral; Membrane protein, multi-pass Q01815 12288 6 F1|6 55.86 cM mouse S1670-p 4714250 PEIRRAIsGDLTAEE CAC1F_C phosphorylation 27103070 17 7 0 ISO-triggered dissociation of the CACNAIC prevents subsequent phosphorylation -Zbed3 ZBED3 DNA-binding Q9D0L1 72114 13|13 D1 mouse T113-p 6738703 CPPPPSPtMAAEGDW molecular association, regulation axin 1(INDUCES) 19141611 1 0 0 interaction beween ZBED3 and axin is important for ZBED3 to inhibit beta catenin (CTNNB1) phosphorylation by GSK3 beta ; activates Wnt signaling -Tbc1d17 TBC1D17 GAP; GAP, Rab Q8BYH7 233204 7|7 B3 mouse S168-p 1873559800 RALLRVLsRYLLLAS PH_RBD intracellular localization; protein conformation; activity, inhibited 34045668 1 0 0 induces GLUT5 translocation -JAK2 JAK2 EC 2.7.10.2; KINASE; Kinase, protein; Oncoprotein; Protein kinase, TK; Protein kinase, tyrosine (non-receptor) O60674 3717 9p24.1 human S518-p 56527201 VFRTNGVsDVPTSPT enzymatic activity, induced transcription, induced 27368100 1 1 0 STAT3 activity induced -BCAM Lu Membrane protein, integral; Receptor, misc. P50895 4059 19q13.32 human S621-p 455912 SGGARGGsGGFGDEC molecular association, regulation cell motility, induced; cell adhesion, induced; cell adhesion, altered Lu(INDUCES) 15975931; 31413112 2 6 0 Dimerization of Lu, induce cell migration on Lamnin 521. -RAF1 RAF1 EC 2.7.11.1; KINASE; Kinase, protein; Oncoprotein; Protein kinase, Ser/Thr (non-receptor); Protein kinase, TKL P05625 396245 chicken Y341-p 447750 GQRDSSYyWEIEASE enzymatic activity, induced apoptosis, inhibited 12843393; 12952943 35 1 1 -Cdh2 CDH2 Cell adhesion; Membrane protein, integral; Motility/polarity/chemotaxis Q9Z1Y3 83501 18p13 rat S872-p 382737702 STAGSLSsLNSSSSG CADH_Y-type_LIR intracellular localization cytoskeletal reorganization CTNNB1(INDUCES) 29133434 1 0 0 PKD1 colocalizes with N-cadherin at dendritic spines mainly in the postsynaptic compartment, long-term potentiation (LTP) induction and regulates synaptic plasticity -Bdkrb2 BKR2 GPCR, family 1; Membrane protein, integral; Membrane protein, multi-pass; Receptor, GPCR P25023 25245 6q32 rat Y352-p 452100 RKKSREVyQAICRKG activity, induced; receptor desensitization, altered 9837936 3 2 0 -PHB2 BAP37 Mitochondrial; Nuclear receptor co-regulator; Transcription, coactivator/corepressor Q99623 11331 12p13.31 human S91-p 22342307 RARPRKIsSPTGSKD Band_7 apoptosis, inhibited; transcription, induced 21689744; 24522204 2 9 1 -Ctbp1 CTBP1 Cell cycle regulation; EC 1.1.1.-; Nuclear receptor co-regulator; Oxidoreductase; Transcription, coactivator/corepressor Q9Z2F5 rat S147-p 455351 REGTRVQsVEQIREV 2-Hacid_dh; 2-Hacid_dh_C molecular association, regulation; intracellular localization neural plasticity; endocytosis, induced PLD1(INDUCES); 14-3-3 gamma(INDUCES); BSN(DISRUPTS) 22366688; 32075774 7 2 0 -MAP4 MAP4 Cytoskeletal; Motility/polarity/chemotaxis P27816 4134 3p21.31 human S928-p 468166 SRLATNTsAPDLKNV Tubulin-binding protein degradation; molecular association, regulation cell cycle regulation; cytoskeletal reorganization; signaling pathway regulation E7(DISRUPTS) 31253867 1 53 122 -NFE2L2 NRF2 DNA-binding; Transcription factor Q16236 4780 2q31.2 human T395-p 40642203 VKQNGPKtPVHSSGD intracellular localization 25909891 1 0 0 nuclear translocation -ADRA2A ADRA2A GPCR, family 1; Membrane protein, integral; Membrane protein, multi-pass; Receptor, GPCR P08913 150 10q25.2 human S314-p 456352 DLEESSSsDHAERPP 7tm_1 activity, inhibited 7876239 1 3 0 -Tubb5 TUBB Cytoskeletal; Motility/polarity/chemotaxis P99024 22154 17|17 B1 mouse S172-p 460692 NTFSVVPsPKVSDTV Tubulin molecular association, regulation TUBB(DISRUPTS) 16371510 1 27 1 inhibits tubulin polymerization in vivo and in vitro -Trpv6 TRPV6 Channel, calcium; Membrane protein, integral; Membrane protein, multi-pass Q9R186 114246 4q23 rat Y201-p 473577 YRPHNLIyYGEHPLS activity, induced 17197020 1 0 0 regulates calcium influx -Gabrg2 GABRG2 Channel, chloride; Channel, ligand-gated; Membrane protein, integral; Membrane protein, multi-pass; Transporter; Transporter, ion channel P22723 14406 11 A5|11 24.8 cM mouse K370-ub 14694705 KPSKDKDkKKKNPLL Neur_chan_memb protein degradation; receptor internalization, altered 19815531 1 0 0 regulation of the late endosomal/lysosomal trafficking of GABA receptors, regulation of synaptic transmission -Mdm2 MDM2 EC 6.3.2.-; EC 6.3.2.19; Inhibitor; Ligase; NEDDYLATION LIGASE; Neddylation Ligase; Nucleolus; Oncoprotein; UBIQUITIN LIGASE; Ubiquitin conjugating system; Ubiquitin ligase P23804 17246 10 D2|10 66.32 cM mouse S163-p 448130 SSRRRSIsETEENTD intracellular localization carcinogenesis, induced; apoptosis, inhibited 20657550; 20841468; 34298892 50 19 5 -GHR GH receptor Membrane protein, integral; Receptor, cytokine P19941 100009325 rabbit Y566-p 486257 SFNQEDIyITTESLT GHBP molecular association, regulation STAT5A(INDUCES); STAT5B(INDUCES) 17666591 3 0 0 -HNRNPK hnRNP K RNA splicing; RNA-binding; Spliceosome P61978 3190 9q21.32 human R296-m1 8092821 PPPPPPGrGGRGGSR molecular association, regulation; phosphorylation apoptosis, inhibited PKCD(DISRUPTS) 25104022 1 3 19 methylation of R296 and R299 suppress S302 phosphorylation, R296/R299 methylation reduces apoptosis in U2OS-K- 2RK cells after DNA damage -CERT1 COL4A3BP EC 2.7.11.9; KINASE; Kinase, protein; Lipid-binding; Protein kinase, Ser/Thr (non-receptor); Protein kinase, atypical Q9Y5P4 10087 5q13.3 human T148-p 4777484 SGYSATStSSFKKGH molecular association, regulation; activity, inhibited 28652409 0 2 0 reduced PtdIns(4)P binding affinity as well as low ceramide transfer activity, E494R/N495K/P535R/E537K mutations, recovery of both PtdIns(4)P binding and ceramide transfer activity. -Tbx2 TBX2 DNA-binding; Transcription factor Q60707 21385 11 C|11 51.34 cM mouse S336-p 1308918 PAREPPPsPSAAPSP TBX activity, induced; protein stabilization; intracellular localization transcription, inhibited 18025091 1 3 0 relocalizes into nuclei after UV radiation -TP53 p53 Activator; DNA-binding; Motility/polarity/chemotaxis; Nuclear receptor co-regulator; Transcription factor; Tumor suppressor P04637 7157 17p13.1 human K305-ac 458979 ELPPGSTkRALPNNT intracellular localization; phosphorylation transcription, induced 12724314; 19339993; 21297583; 31680191 7 3 13 20, 164, 305, 320, 370/372/373, 381/382/386 K-R mutants diminsished transactivation, and selective regulation of target genes expression through distinct mechanisms -CCNH CCNH Cell cycle regulation P51946 902 5q14.3 human S304-p 12521707 YEDDDYVsKKSKHEE transcription, altered; cell growth, altered 10993082 1 0 1 -Vav3 VAV3 Actin-binding; Adaptor/scaffold; GEF; GEF, Rac/Rho; Motility/polarity/chemotaxis; Nuclear receptor co-regulator Q9R0C8 57257 3|3 F3 mouse Y173-p 455605 EDEGGEVyEDLMKAE activity, induced 35650206 6 0 0 -Srebf1 SREBP-1 DNA-binding; Membrane protein, integral; Membrane protein, multi-pass; Transcription factor P56720 78968 10q22 rat S332-p 458357 IEKRYRSsINDKIVE HLH transcription, inhibited 24853806 4 1 0 -ERCC3 XPB DNA repair, damage; EC 3.6.4.12; Helicase; Transcription factor P19447 2071 2q14.3 human S90-p 1867858202 HIFLEAFsPVYKYAQ Helicase_C_3 protein degradation; ubiquitination 30762924 1 0 0 polyubiquitination by SCF E3 ligase -Ptprr PTP-SL iso2 EC 3.1.3.48; Membrane protein, integral; Motility/polarity/chemotaxis; PHOSPHATASE; Receptor protein phosphatase, tyrosine Q62132-2 19279 10|10 D2 mouse T253-p 450119 EPFVAVStPREKVAM molecular association, regulation 9857190 2 0 1 -Atp2a2 SERCA2 Cell adhesion; EC 3.6.3.8; Endoplasmic reticulum; Hydrolase; Membrane protein, integral; Membrane protein, multi-pass; Transporter; Transporter, ion channel O55143 11938 5 62.38 cM|5 F mouse S663-p 452253 EFDELSPsAQRDACL enzymatic activity, inhibited cell growth, inhibited 37291092 1 69 3 ,regulates Ca2+ homeostasis -Marcks MARCKS Actin-binding; Motility/polarity/chemotaxis P26645 17118 10 B1|10 19.49 cM mouse S46-p 454165 VKVNGDAsPAAAEPG MARCKS protein conformation 31980612 3 41 0 -Ksr1 KSR KINASE; Kinase, protein; Protein kinase, Ser/Thr (non-receptor); Protein kinase, TKL Q61097 16706 11 B5|11 46.74 cM mouse T549-p 4956353 ISRKASQtSVYLQEW phosphorylation 23993095 1 0 2 induces phosphorylation of ERK -NGEF ephexin-1 GEF; GEF, Rac/Rho Q8N5V2 25791 2q37.1 human S18-p 34499273 KTRRKSAsDQWNTDN molecular association, regulation; phosphorylation carcinogenesis, induced; cell growth, induced; signaling pathway regulation KRas(INDUCES) 34711817 1 2 0 induces C-Raf phosphorylation, induces Ras/MAPK signaling pathway -Gria2 GluR2 Channel, calcium; Channel, ligand-gated; Membrane protein, integral; Membrane protein, multi-pass P19491 29627 2q33 rat K882-ub 7253603 VYGIESVkI______ protein degradation; intracellular localization 25660027 2 0 1 -NOX5 NOX5 EC 1.6.3.-; Membrane protein, integral; Membrane protein, multi-pass; Oxidoreductase Q96PH1 79400 15q23 human Y478-p 1869973808 YRPGDYLyLNIPTIA FAD_binding_8 signaling pathway regulation 32792487 1 0 0 activation of Src, Pyk2-mediated phosphorylation of Nox5 -ARFIP1 arfaptin 1 iso2 G protein regulator, misc. P53367-2 27236 4q31.3 human S100-p 3191827 LELVRKWsLNTYKCT Arfaptin molecular association, regulation; intracellular localization arfaptin 2(DISRUPTS) 23695357 3 32 43 dissociation from trans-Golgi network; inhibits intracellular localization of TGN -Map3k3 MEKK3 EC 2.7.11.25; KINASE; Kinase, protein; Protein kinase, STE; Protein kinase, Ser/Thr (non-receptor) Q61084 26406 11|11 E1 mouse S166-p 3188100 EPRSRHLsVSSQNPG enzymatic activity, inhibited 12761204 2 32 42 -MAVS MAVS Adaptor/scaffold; Membrane protein, integral Q7Z434 57506 20p13 human K461-ub 14991109 GPEENEYkSEGTFGI protein degradation; molecular association, regulation MAVS(INDUCES) 20483786; 27992402; 31270229 3 0 0 -F11R JAM-A Cell adhesion; Membrane protein, integral Q9Y624 50848 1q23.3 human Y280-p 458767 TSSKKVIySQPSARS molecular association, regulation cell motility, induced CSK(INDUCES) 24300854; 35293964 3 27 902 -HTT Huntingtin Cytoskeletal P42858 3064 4p16.3 human S2114-p 1870026105 QCWTRSDsALLEGAE activity, induced; molecular association, regulation; protein conformation PRRC2C(DISRUPTS) 32668197 1 1 0 -USP8 USP8 DEUBIQUITINASE; EC 3.4.19.12; Protease; Ubiquitin conjugating system; Ubiquitin-specific protease P40818 9101 15q21.2 human Y810-p 23071951 DYFNRNCyQDDINRS UCH cell cycle regulation 29472535 1 1 2 trichoplein-mediated inhibition of ciliogenesis -AKT3 Akt3 EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, AGC; Protein kinase, Ser/Thr (non-receptor) Q9Y243 10000 1q43-q44 human T305-p 448521 TDAATMKtFCGTPEY Pkinase phosphorylation carcinogenesis, induced; cell growth, induced 36476861 9 5 11 induces TSC2 phosphorylation -ITPKB ITPKB Carbohydrate Metabolism - inositol phosphate; EC 2.7.1.127; Kinase, lipid; Motility/polarity/chemotaxis P27987 3707 1q42.12 human S174-p 3189511 PRLGRARsPSPCPFR molecular association, regulation; enzymatic activity, induced carcinogenesis, induced Calmodulin(INDUCES) 35039634 1 26 8 -FYN Fyn EC 2.7.10.2; KINASE; Kinase, protein; Oncoprotein; Protein kinase, TK; Protein kinase, tyrosine (non-receptor) P06241 2534 6q21 human Y214-p 455043 KLDNGGYyITTRAQF SH2 activity, induced; molecular association, regulation; protein conformation; enzymatic activity, induced 17389760; 27001024 2 22 656 autophosphorylation reduces its ability to bind to ESDN/DCBLD2; hyper-active conformation of Fyn ; reduces SH2-dependent binding interactions -Git1 GIT1 GAP; GAP, ARF; Motility/polarity/chemotaxis Q9Z272 83709 10q24 rat Y554-p 448965 ELEDDAIySVHVPAG molecular association, regulation cell motility, induced eNOS(INDUCES); PXN(DISRUPTS); Hic-5(DISRUPTS) 24764294; 25742295 4 39 737 phosphorylation-dephosphorylation required for coordinated cell movement, Y545-p was essential for Git1-mediated protrusion activity. -SATB1 SATB1 DNA-binding; Transcription factor Q01826 6304 3p24.3 human T188-p 13906400 PEQWSHTtVRNALKD CUTL sumoylation; molecular association, regulation; intracellular localization PIAS1(DISRUPTS) 20351170 1 0 0 -TTK TTK Cancer Testis Antigen (CTA); EC 2.7.12.1; KINASE; Kinase, protein; Protein kinase, Other; Protein kinase, dual-specificity (non-receptor) P33981 7272 6q14.1 human T676-p 487540 NQMQPDTtSVVKDSQ Pkinase activity, induced; molecular association, regulation; intracellular localization; enzymatic activity, induced cell cycle regulation; carcinogenesis, inhibited; chromatin organization, altered; cytoskeletal reorganization TTK(NOT_REPORTED) 17728254; 18083840; 18545697; 18680479; 26119734; 31511308; 34775484 15 5 0 -CTNNA2 CTNNA2 Cancer Testis Antigen (CTA); Cytoskeletal; Motility/polarity/chemotaxis P26232 1496 2p12 human K696-ub 52485009 IFHQEKSkLDAEVAK Vinculin protein degradation 26676607 0 1 0 -PIP5K1C PIP5K1C Carbohydrate Metabolism - inositol phosphate; EC 2.7.1.68; Kinase, lipid; Motility/polarity/chemotaxis O60331 23396 19p13.3 human S650-p 457599 DERSWVYsPLHYSAQ molecular association, regulation; intracellular localization; phosphorylation cytoskeletal reorganization; cell adhesion, altered talin 1(DISRUPTS) 15738269 2 1 0 inhibits phosphorylation at PIP5KG at Y649 -NR3C2 MCR DNA-binding; Nuclear receptor P08235 4306 4q31.23 human K428-sm 3287300 SSFSVPIkQESTKHS transcription, inhibited 14500761 2 3 0 -Sod2 SOD2 EC 1.15.1.1; Mitochondrial; Oxidoreductase P09671 20656 17 A1|17 8.75 cM mouse K89-ac 33350066 VALQPALkFNGGGHI Sod_Fe_N protein conformation; enzymatic activity, altered 28433661 0 3 0 -SOX8 SOX8 DNA-binding P57073 30812 16p13.3 human S327-p 4715062 SAPSASAsPTETGPP intracellular localization carcinogenesis, induced; apoptosis, inhibited; transcription, altered; signaling pathway regulation 32550913 1 2 0 AurA/SOXB/FOXK1 signaling pathway -DUSP12 DUSP12 EC 3.1.3.16; EC 3.1.3.48; Motility/polarity/chemotaxis; PHOSPHATASE; Protein phosphatase, dual-specificity Q9UNI6 11266 1q23.3 human Y179-p 1880475700 VDTSSAIyKQYRLQK intracellular localization 36370849 1 1 0 -Flt3 FLT3 EC 2.7.10.1; KINASE; Kinase, protein; Membrane protein, integral; Oncoprotein; Protein kinase, TK; Protein kinase, tyrosine (receptor) Q00342 14255 5 86.88 cM|5 G3 mouse Y845-p 454872 DILSDSSyVVRGNAR PK_Tyr_Ser-Thr protein stabilization; enzymatic activity, induced 16091740 5 2 76 -VCP VCP Chaperone; DNA repair, damage; EC 3.6.4.6; Endoplasmic reticulum; Hydrolase P55072 7415 9p13.3 human S746-p 457557 AMRFARRsVSDNDIR Vps4_C apoptosis, inhibited 16551632 2 5 1 -GAPDH GAPDH Carbohydrate Metabolism - glycolysis and gluconeogenesis; EC 1.2.1.12; Oxidoreductase P04406 2597 12p13.31 human R248-m2 1878232000 SVVDLTCrLEKPAKY enzymatic activity, induced GAPDH(INDUCES) 31324208 1 1 0 enhances GAPDH activity by promoting the assembly of an active tetramer, promotes glycolysis and mitochondrial respiration, PRMT3 increases the sensitivity of pancreatic cancer cells to GAPDH blockage -CDT1 CDT1 DNA replication; DNA-binding; Motility/polarity/chemotaxis; Oncoprotein Q9H211 81620 16q24.3 human S411-p 21440504 PATPPAAsPSALKGV protein stabilization; molecular association, regulation; activity, inhibited; phosphorylation RAMP(DISRUPTS); MCM2(DISRUPTS) 21930785; 32841231 2 0 1 inhibits Chk1 phosphorylation -Prkcb PKCB iso2 EC 2.7.11.13; KINASE; Kinase, protein; Motility/polarity/chemotaxis; Protein kinase, AGC; Protein kinase, Ser/Thr (non-receptor) P68404-2 18751 7 F2|7 65.75 cM mouse T641-p 1869073010 TRHPPVLtPPDQEVI Pkinase_C molecular association, regulation; protein conformation; phosphorylation; enzymatic activity, induced PKCB iso2(DISRUPTS) 33850054 9 41 44 induces phosphorylation at S660 -NFATC1 NFAT2 DNA-binding; Transcription factor O95644 4772 18q23 human S153-p 1869090803 PSSKRSPsTATLSLP activity, induced carcinogenesis, induced; cell motility, induced; transcription, induced 31730483 1 1 0 multiple sites mutatnt -SGK1 SGK1 EC 2.7.11.1; KINASE; Kinase, protein; Motility/polarity/chemotaxis; Protein kinase, AGC; Protein kinase, Ser/Thr (non-receptor) O00141 6446 6q23.2 human T256-p 448431 EHNSTTStFCGTPEY Pkinase molecular association, regulation; phosphorylation; enzymatic activity, induced apoptosis, inhibited; transcription, induced; signaling pathway regulation 10191262; 11096081; 11956329; 18456663; 22042038; 25384981; 33890983 15 0 0 induces phosphorylation of NEDD4L and CFTR; regulates aldosterone-stimulated SGK1-NFkB pathway for glomerular fibrosis and inflammation; HSP90 is required for SGK kinase activity.; IkB phosphorylation increased; phosphorylates Tau at S214; adhesion dependent activation -Etv4 ETV4 DNA-binding P28322 18612 11 D|11 65.48 cM mouse K112-ac 26373302 PALSCSRkPPLPYHH ETS_PEA3_N sumoylation transcription, induced 21543453 1 1 0 acetylated sites inhibits sumoylation reciprocally -Lin28a LIN28A Nucleolus; RNA-binding; Translation Q8K3Y3 83557 4|4 D3 mouse S200-p 7231811 EEEEEIHsPALLPEA activity, inhibited cell growth, inhibited; cell differentiation, induced 28179426 1 5 0 increase in let7a and let7g miRNA and decrease in cyclin D1 levels -SH3PXD2B SH3PXD2B Lipid-binding A1X283 285590 5q35.1 human Y508-p 17303901 DMSASAGyEEISDPD molecular association, regulation carcinogenesis, altered; cytoskeletal reorganization NOXA1(INDUCES) 20943948 1 0 0 -WNK4 WNK4 EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, Other; Protein kinase, Ser/Thr (non-receptor) Q96J92 65266 17q21.2 human Y1113-p 40407606 PSPVWMNySYSSLCL activity, inhibited 25805816 1 1 0 WNK4 inhibition of ROMK channels -TTK TTK Cancer Testis Antigen (CTA); EC 2.7.12.1; KINASE; Kinase, protein; Protein kinase, Other; Protein kinase, dual-specificity (non-receptor) P33981 7272 6q14.1 human S281-p 1737603 VPVNLLNsPDCDVKT protein stabilization; ubiquitination; intracellular localization cell cycle regulation; carcinogenesis, induced; cytoskeletal reorganization; signaling pathway regulation CDC27(DISRUPTS) 22430208; 30674582 2 29 1 accumulation at centrosomes, aneuploidy, correlated with p-ERK, in human metastatic melanoma; MAD1 checkpoint signaling; centrosome reduplication -Stat5a STAT5A DNA-binding; Motility/polarity/chemotaxis; Oncoprotein; Transcription factor P42230 20850 11 D|11 63.77 cM mouse S779-p 448750 DSLDARLsPPAGLFT activity, induced; molecular association, regulation; intracellular localization carcinogenesis, altered; cell growth, induced; transcription, induced HER4(INDUCES) 12732616; 15863494; 20508164; 24263804 12 25 0 -PDPK1 PDK1 EC 2.7.11.1; KINASE; Kinase, protein; Nuclear receptor co-regulator; Protein kinase, AGC; Protein kinase, Ser/Thr (non-receptor) O15530 5170 16p13.3 human T354-p 25256100 WENLHQQtPPKLTAY molecular association, regulation; enzymatic activity, inhibited apoptosis, altered; cell growth, inhibited; signaling pathway regulation 14-3-3 beta(INDUCES); STRAP(DISRUPTS) 22544756 2 0 0 alleviates PDK1-mediated supression of apoptosis -IGF1R IGF1R EC 2.7.10.1; KINASE; Kinase, protein; Membrane protein, integral; Protein kinase, TK; Protein kinase, tyrosine (receptor) P08069 3480 15q26.3 human S1278-p 4271095 EPGFREVsFYYSEEN protein stabilization; molecular association, regulation; phosphorylation signaling pathway regulation ARRB1(INDUCES) 22509025 1 0 1 S1278 induces transient association, while S1321 induces more stable association; Akt phosphorylation, regulates ERK/Akt signaling pathway -Nhej1 NHEJ1 DNA repair, damage Q3KNJ2 75570 1|1 C4 mouse S245-p 4084901 TQASSSTsPRGTDNQ activity, induced; molecular association, regulation RFC4(INDUCES); RFC1(INDUCES) 31123184 2 5 0 induce replication fork stability -MC1R MC1R GPCR, family 1; Membrane protein, integral; Membrane protein, multi-pass; Receptor, GPCR Q01726 4157 16q24.3 human T308-p 471419 HSQELRRtLKEVLTC receptor internalization, altered 17130136 1 0 0 T308 and S316 phosphorylation regulate MC1R internalization and desensitization. -Kcna1 Kv1.1 Channel, potassium; Membrane protein, integral; Membrane protein, multi-pass P10499 24520 4q42 rat S446-p 451079 SDLSRRSsSTISKSE activity, induced 9497384 2 0 0 Reduces the extent of inactivation of the channel -SOX9 SOX9 DNA-binding; Transcription factor P48436 6662 17q24.3 human S211-p 450957 FKALQADsPHSSSGM protein stabilization transcription, induced 27929080 2 1 0 PAPSS2 mRNA expression -STK38 NDR1 EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, AGC; Protein kinase, Ser/Thr (non-receptor) Q15208 11329 6p21.31 human T183-p 41425402 TLLMKKDtLTEEETQ Pkinase molecular association, regulation; intracellular localization; enzymatic activity, inhibited; protein conformation cell cycle regulation; cytoskeletal reorganization MOB1A(DISRUPTS); HCCA2(INDUCES) 26057687 1 0 0 regulation of spindle orientation, cortical localization of LGN-NuMA -PPP2CA PPP2CA EC 3.1.3.16; Motility/polarity/chemotaxis; PHOSPHATASE; Protein phosphatase, Ser/Thr (non-receptor) P67775 5515 5q31.1 human T304-p 450083 EPHVTRRtPDYFL__ molecular association, regulation; methylation; enzymatic activity, inhibited; enzymatic activity, induced cell cycle regulation; cytoskeletal reorganization; cell growth, altered PPP2R2B(DISRUPTS); PPP2R5A(DISRUPTS); PPP2R2C(DISRUPTS); PPP2R3B(INDUCES); PPP2R5D(INDUCES); PPP2R5C(DISRUPTS); PPP2R2A(NOT_REPORTED); PPP2R3A(INDUCES) 10978272; 17394530; 17635907; 32900880; 37437018 7 11 2 -DRD1 DRD1 GPCR, family 1; Membrane protein, integral; Membrane protein, multi-pass; Receptor, GPCR P21728 1812 5q35.2 human S254-p 1869357202 NGKPVECsQPESSFK 7tm_1 molecular association, regulation ARR3(INDUCES) 32503917 1 0 0 -Hnrnpm hnRNP M Nucleolus; RNA splicing; RNA-binding; Receptor, misc.; Spliceosome Q9D0E1 76936 17|17 B1 mouse S574-p 3191716 LERMGANsLERMGLE molecular association, regulation RNA splicing, induced DNA(DISRUPTS) 31693898 1 42 4 inhibits binding at the IL-6 locus -STAT1 STAT1 DNA-binding; Transcription factor P42224 6772 2q32.2 human K525-m1 1873284300 QLNMLGEkLLGPNAS activity, induced; molecular association, regulation; phosphorylation transcription, induced DNA(INDUCES) 28753426 1 1 0 induces interferon antiviral activity -Prkcd PKCD EC 2.7.11.13; KINASE; Kinase, protein; Nuclear receptor co-regulator; Protein kinase, AGC; Protein kinase, Ser/Thr (non-receptor); Protein kinase, tyrosine (non-receptor); Tumor suppressor P28867 18753 14 B|14 18.82 cM mouse Y565-p 447576 IRVDTPHyPRWITKE Pkinase enzymatic activity, inhibited carcinogenesis, inhibited 11812791 5 0 0 -IRF1 IRF1 Transcription factor; Tumor suppressor P10914 3659 5q31.1 human K50-ub 31914111 KHGWDINkDACLFRS IRF protein degradation; molecular association, regulation DNA(DISRUPTS) 23134341 1 2 0 -POLH POLH DNA repair, damage; EC 2.7.7.7; Transferase Q9Y253 5429 6p21.1 human K462-sm 1877365905 PVTSSEAkTQGSGPA intracellular localization; enzymatic activity, inhibited 32350109 1 1 0 -SLC12A3 NCCT Membrane protein, integral; Membrane protein, multi-pass; Transporter; Transporter, SLC family P55017 6559 16q13 human K828-ub 27200754 IFQSEQGkKTIDIYW SLC12 protein degradation; ubiquitination; activity, inhibited; phosphorylation endocytosis, induced 29021560 1 2 0 NCC transport activity decreased. phosphorylation inhibited -ETAA1 ETAA16 Cell surface Q9NY74 54465 2p14 human S111-p 1869465806 DIFWDQNsPLTKQLG ETAA1 cell cycle regulation; signaling pathway regulation 31615875 1 0 0 critical for chromosome stability -SH3BP2 SH3BP2 Adaptor/scaffold P78314 6452 4p16.3 human S278-p 455470 PATPRRMsDPPLSTM molecular association, regulation 14-3-3 theta(INDUCES) 12501243 1 11 1 -CTNNB1 CTNNB1 Actin-binding; Cell adhesion; Motility/polarity/chemotaxis; Nuclear receptor co-regulator; Oncoprotein; Transcription factor P35222 1499 3p22.1 human S646-p 41656202 PLTELLHsRNEGVAT intracellular localization 26187068 1 0 0 -RPS6KB1 p70S6K iso2 EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, AGC; Protein kinase, Ser/Thr (non-receptor); Translation P23443-2 6198 17q23.1 human T229-p 448606 HDGTVTHtFCGTIEY Pkinase enzymatic activity, induced 18326039 36 2 17 -ABCA4 ABCA4 Membrane protein, integral; Membrane protein, multi-pass; Transporter; Transporter, ABC family P78363 24 1p22.1 human T1313-p 20940700 PREKAGQtPQDSNVC enzymatic activity, induced 21721517 1 1 0 -Asic3 ASIC3 Channel, cation; Membrane protein, integral; Membrane protein, multi-pass; Transporter; Transporter, ion channel O35240 286920 4q11 rat T40-p 12518704 IFGPGGLtLRRGLWA TM; ASC activity, induced 14976185 1 0 0 channel activation -Nr1h3 LXR-alpha DNA-binding; Motility/polarity/chemotaxis; Nuclear receptor Q9Z0Y9 22259 2 E1|2 50.52 cM mouse S196-p 469114 SVSPRVSsPPQVLPQ molecular association, regulation; activity, inhibited chromatin organization, altered; cell growth, inhibited; transcription, altered; transcription, inhibited; signaling pathway regulation SRC-1(DISRUPTS); N-CoR1(INDUCES); RXRA(DISRUPTS) DNA(DISRUPTS) 17296605; 29950315; 30673619 6 0 0 -TARDBP TDP-43 RNA-binding Q13148 23435 1p36.22 human K145-ac 38520208 DLKTGHSkGFGFVRF RRM_1 molecular association, regulation; phosphorylation transcription, inhibited RNA(DISRUPTS) 25556531; 32409664 2 1 0 enhances TDP-43 phosphorylation, enhances accumulation of TDP-43 aggregates; TDP-43-induced cell toxicity -Cacng2 Stargazin Channel, calcium; Membrane protein, integral; Membrane protein, multi-pass O88602 12300 15 E1|15 36.92 cM mouse S249-p 455320 RSTEPSHsRDASPVG activity, induced; intracellular localization 15664178; 20670832 3 1 1 AMPAR immobilization in synaptic membrane; enhances AMPA receptor responses and is required for long-term potentiation -Vamp2 VAMP2 Membrane protein, integral; Motility/polarity/chemotaxis; Vesicle P63045 24803 10q24 rat S75-p 481819 DALQAGAsQFETSAA Synaptobrevin exocytosis, altered; endocytosis, altered 33582301 1 14 39 -Erg ERG DNA-binding; Oncoprotein; Transcription factor P81270 13876 16 C4|16 56.04 cM mouse S103-p 4712353 KGGKMVGsPDTVGMS methylation carcinogenesis, induced; cell motility, induced; cell growth, induced; transcription, induced 34314419 4 5 0 inhibits H3 methylation -NEDD8 NEDD8 Ubiquitin-like modifier Q15843 4738 14q12 human K22-ac 36299402 IDIEPTDkVERIKER ubiquitin molecular association, regulation PARP1(INDUCES) 30804002 1 2 0 -Notch1 Notch 1 Membrane protein, integral; Motility/polarity/chemotaxis; Oncoprotein; Receptor, misc.; Transcription factor Q01705 18128 2 A3|2 18.91 cM mouse K1935-ac 18899511 YSRSDAAkRLLEASA Ank_2 protein stabilization; ubiquitination 21499261 1 1 0 -NR1I2 PXR DNA-binding; Nuclear receptor O75469 8856 3q13.33 human T135-p 30259804 KKSERTGtQPLGVQG molecular association, regulation RXRA(DISRUPTS) DNA(DISRUPTS) 24184507; 32205367 2 2 0 -PSRC1 PSRC1 Q6PGN9 84722 1p13.3 human S65-p 12667967 APQGVRLsLGPLSPE GTSE1_N cytoskeletal reorganization 21473853 1 11 0 -KCNA3 Kv1.3 Channel, potassium; Membrane protein, integral; Membrane protein, multi-pass P22001 3738 1p13.3 human Y529-p 52427503 STLSKSEyMVIEEGG cell growth, induced 26655221 1 0 0 -Ppif PPIF Cyclophilin; EC 5.2.1.8; Isomerase; Mitochondrial Q99KR7 105675 14|14 A3 mouse S42-p 1241945800 ARGANSSsGNPLVYL molecular association, regulation ATP5A1(INDUCES) 30165576 1 1 0 S42D increased interaction and cell death compared to S42A mutant -EGFR EGFR EC 2.7.10.1; KINASE; Kinase, protein; Membrane protein, integral; Oncoprotein; Protein kinase, TK; Protein kinase, tyrosine (receptor) P00533 1956 7p11.2 human Y1110-p 448058 GSVQNPVyHNQPLNP molecular association, regulation; ubiquitination; receptor internalization, altered; intracellular localization; protein conformation; phosphorylation; enzymatic activity, induced DNA repair, induced; carcinogenesis, induced; cell motility, induced; transcription, altered; signaling pathway regulation RASA1(INDUCES); GRB2(INDUCES); Src(INDUCES); DOK2(INDUCES); DOK1(INDUCES); SHC1(INDUCES); STAT3(INDUCES); CBL(INDUCES) DNA(INDUCES) 10069801; 10508618; 12631709; 12873986; 1314835; 15476828; 16729043; 23644655; 24430869; 26290602; 29989005; 34367939; 35000271; 7741752; 8408058 45 38 457 EGFR autophosphorylation sites modulate STAT activation. -Kdm1a LSD1 DEMETHYLASE; Demethylase; EC 1.-.-.-; Nuclear receptor co-regulator; Oxidoreductase; Transcription factor Q6ZQ88 99982 4 D3|4 68.8 cM mouse S112-p 3828907 TPEGRRTsRRKRAKV molecular association, regulation; intracellular localization; enzymatic activity, induced transcription, induced; transcription, inhibited DNA(INDUCES) 24582500; 34078525 4 1 10 -EXO5 DEM1 EC 3.1.11.- Q9H790 64789 1p34.2 human Y221-p 1874115105 DCFQVSLyKYIFDAM molecular association, regulation; enzymatic activity, induced DNA repair, induced DNA(INDUCES) 34197737 1 0 0 -NFE2L2 NRF2 DNA-binding; Transcription factor Q16236 4780 2q31.2 human S347-p 18258501 NDSDSGIsLNTSPSV protein degradation; molecular association, regulation; ubiquitination transcription, inhibited BTRC(INDUCES) 22751928; 32295843 4 1 0 -YAP1 YAP1 Oncoprotein; Transcription, coactivator/corepressor P46937 10413 11q22.1 human S128-p 485035 QHVRAHSsPASLQLG activity, induced; molecular association, regulation; intracellular localization cell cycle regulation; cell differentiation, induced; cell motility, induced; cell growth, induced; apoptosis, inhibited; transcription, induced; transcription, inhibited TEAD1(INDUCES); TEAD4(DISRUPTS); 14-3-3 beta(DISRUPTS) 24812269; 27979971; 27979972; 28416665; 36640330; 37100374 8 12 77 -Panx1 PANX1 Cell adhesion; Membrane protein, integral; Membrane protein, multi-pass P60570 315435 8q12 rat S328-p 1871464503 SEGYNDLsLYNLFLE activity, inhibited 33276429 1 0 0 inhibits mechanical stretch induced activation of Panx1 channels -HTT Huntingtin Cytoskeletal P42858 3064 4p16.3 human K6-ac 10206806 __MATLEkLMKAFES protein stabilization; protein conformation 28334491 2 1 0 reverses inhibitory effect of T3 phosphorylation on aggregation -MLXIPL ChREBP Transcription factor Q9NP71 51085 7q11.23 human S196-p 451393 KKRLRKPsREDDLLA molecular association, regulation; intracellular localization 14-3-3 beta(INDUCES); KPNA2(DISRUPTS) 23918932 5 8 1 regulates lipogenesis -Raet1e RAET1E Membrane protein, integral Q9CZQ6 379043 10|10 A3 mouse K87-ac 1877559400 KMANATGkCLTQPLN MHC_I_2 protein stabilization 33279621 1 0 0 protects RAET1E from shedding; induces antitumor immunity -ROCK1 ROCK1 EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, AGC; Protein kinase, Ser/Thr (non-receptor) Q13464 6093 18q11.1 human T1024-p 20609219 IDRKKANtQDLRKKE intracellular localization cytoskeletal reorganization 21685893 1 1 0 inhibits apical constriction -EGFR EGFR EC 2.7.10.1; KINASE; Kinase, protein; Membrane protein, integral; Oncoprotein; Protein kinase, TK; Protein kinase, tyrosine (receptor) P00533 1956 7p11.2 human S1042-p 3178887 LSSLSATsNNSTVAC receptor internalization, induced; protein degradation 24797263 2 9 2 -Lrp1 LRP1 Cell surface; Membrane protein, integral; Motility/polarity/chemotaxis; Receptor, misc. Q91ZX7 16971 10|10 D3 mouse Y4508-p 451245 TNFTNPVyATLYMGG activity, induced; receptor internalization, induced; molecular association, regulation cell cycle regulation; signaling pathway regulation CSK(INDUCES); RAB8A(INDUCES) 20724593; 30208326 6 1 0 regulates Akt/mTOR in inflammation -Bsn BSN Cytoskeletal O88737 12217 9 F1|9 59.07 cM mouse S2860-p 456576 KTLQRSLsDPKPLSP molecular association, regulation neural plasticity 14-3-3 eta(INDUCES) 23516560 2 18 1 -CDKN1A p21Cip1 Cell cycle regulation; Inhibitor P38936 1026 6p21.2 human T145-p 447837 QGRKRRQtSMTDFYH protein degradation; protein stabilization; molecular association, regulation; intracellular localization; phosphorylation cell cycle regulation; carcinogenesis, induced; cell motility, induced; cell growth, induced; cell growth, inhibited CDK4(DISRUPTS); Akt2(DISRUPTS); CDK2(DISRUPTS); PCNA(DISRUPTS) 11231573; 11463845; 11756412; 15001356; 15173090; 16982699; 17855660; 20307683; 21159648; 26436589; 34069970 20 0 0 -RIOK1 RIOK1 EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, Ser/Thr (non-receptor); Protein kinase, atypical Q9BRS2 83732 6p24.3 human K411-m1 877067500 EIASQRTkEERSSQD protein degradation; ubiquitination cell growth, inhibited 29384474 1 1 0 RIOK1 methylation reduces the tumor growth and metastasis in mice model -Dab1 DAB1 iso2 Adaptor/scaffold P97318-2 13131 4 C6|4 47.79 cM mouse S515-p 479423 IFEEGFEsPSKSEEQ phosphorylation 16529723 1 0 0 inhibits tyrosine phosphorylation -POLI POLI DNA repair, damage; EC 2.7.7.7; Transferase Q9UNA4 11201 18q21.2 human K547-ub 22249753 QEEILSGkSREKFQG protein degradation 26370087 1 4 0 -H3C1 H3 DNA-binding P68431 8350 6p22.2 human K23-ac 458999 PRKQLATkAARKSAP Histone molecular association, regulation cell cycle regulation; DNA repair, induced; apoptosis, induced; chromatin organization, altered; transcription, induced; transcription, inhibited TIF1G(INDUCES) DNA(DISRUPTS) 20720004; 21726812; 23653357; 35222362; 36060800 32 28 422 -TRPV1 TRPV1 Channel, cation; Membrane protein, integral; Membrane protein, multi-pass; Receptor, misc. Q8NER1 7442 17p13.2 human S502-p 450016 YFLQRRPsMKTLFVD Ion_trans receptor desensitization, altered; intracellular localization 18701070; 31563651 19 0 0 -SMAD7 SMAD7 DNA-binding; Transcription factor O15105 4092 18q21.1 human K70-m1 59102100 GKAVRGAkGHHHPHP protein degradation; acetylation; ubiquitination transcription, inhibited; signaling pathway regulation RNF111(INDUCES) 27292644 1 1 0 TGF-beta signaling- regulates TGF-beta mediated activation of extracellular matrix genes, prevents acetylation, induces lung fibrosis -Rps6 S6 Translation P62754 20104 4|4 C4 mouse S240-p 448094 RLSSLRAsTSKSESS carcinogenesis, induced; carcinogenesis, inhibited 23361300; 33826903 111 69 847 -SREBF1 SREBP-1 DNA-binding; Membrane protein, integral; Membrane protein, multi-pass; Transcription factor P36956 6720 17p11.2 human S63-p 23940711 AGGTDPAsPDTSSPG transcription, induced 22384276 2 1 0 -PIK3CD PIK3CD Carbohydrate Metabolism - inositol phosphate; EC 2.7.1.153; KINASE; Kinase, lipid; Motility/polarity/chemotaxis O00329 5293 1p36.22 human S1039-p 466429 NWLAHNVsKDNRQ__ enzymatic activity, inhibited carcinogenesis, induced; cell growth, induced; apoptosis, inhibited 10064595; 24213578 2 9 0 -Shank3 SHANK3 Adaptor/scaffold Q9JLU4 59312 7q34 rat S781-p 471376 KGIPRTKsVGEDEKL neural plasticity 33568460 1 10 0 -AKAP12 AKAP12 Adaptor/scaffold Q02952 9590 6q25.1 human S627-p 476343 KKRVRRPsESDKEDE WSK receptor desensitization, inhibited; molecular association, regulation ADRB2(INDUCES) 14657015 2 50 245 -PRMT5 PRMT5 Cell cycle regulation; EC 2.1.1.125; METHYLTRANSFERASE; Methyltransferase; Methyltransferase, protein arginine; RNA processing O14744 10419 14q11.2 human Y304-p 18545701 YELFAKGyEDYLQSP PRMT5 molecular association, regulation; enzymatic activity, inhibited carcinogenesis, altered; cell growth, altered PRMT5(DISRUPTS) 21316606 1 0 0 contributes to the mutant Jak2 V617F -induced myeloproliferative phenotype; negatively regulates hematopoietic stem/progenitor cell expansion and erythroid differentiation -SRPK2 SRPK2 EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, CMGC; Protein kinase, Ser/Thr (non-receptor) P78362 6733 7q22.3 human S497-p 483632 SRTVSASsTGDLPKA intracellular localization; phosphorylation transcription, induced 29153836 1 47 1 transcription of genes involved in de novo lipid synthesis; nuclear translocation; S494 phosphorylation by S6K1 primes S497 phosphorylation by CK1 -PIDD1 PIDD Q9HB75 55367 11p15.5 human T788-p 25680403 DAETGFLtQSNLLSV molecular association, regulation cell cycle regulation; apoptosis, induced; apoptosis, inhibited; signaling pathway regulation CRADD(INDUCES); RIPK1(DISRUPTS) 22854598; 25301067 2 0 0 Caspase-2 activation, Mdm2 cleavage, increased p53 levels and drug resistance -MYLK smMLCK EC 2.7.11.18; KINASE; Kinase, protein; Protein kinase, CAMK; Protein kinase, Ser/Thr (non-receptor) Q15746 4638 3q21.1 human S343-p 468783 PVLQKTSsSITLQAA 23ISL carcinogenesis, induced; cell motility, induced; cytoskeletal reorganization 35278271 1 10 1 -EGFR EGFR EC 2.7.10.1; KINASE; Kinase, protein; Membrane protein, integral; Oncoprotein; Protein kinase, TK; Protein kinase, tyrosine (receptor) P00533 1956 7p11.2 human K745-ub 27187821 VKIPVAIkELREATS PK_Tyr_Ser-Thr protein stabilization 32669362 1 3 0 SMURF2-UBE2D1 protein?protein interaction affects mutant EGFR levels -CHEK1 Chk1 EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, CAMK; Protein kinase, Ser/Thr (non-receptor); Tumor suppressor O14757 1111 11q24.2 human S345-p 447834 LVQGISFsQPTCPDH protein degradation; protein stabilization; molecular association, regulation; phosphorylation; enzymatic activity, induced; activity, induced; ubiquitination; intracellular localization cell cycle regulation; carcinogenesis, induced; apoptosis, altered; carcinogenesis, inhibited; apoptosis, induced; cell growth, inhibited; transcription, induced; transcription, altered; signaling pathway regulation; DNA repair, induced; cell growth, induced; apoptosis, inhibited; DNA repair, inhibited 14-3-3 sigma(INDUCES); p53(INDUCES); claspin(INDUCES); p21Cip1(INDUCES) DNA(INDUCES) 10859164; 11390642; 11896572; 12588868; 14729972; 15707391; 15870257; 16137618; 17940005; 19091954; 20609246; 21907702; 23684611; 24240236; 24639502; 24876101; 26082189; 27753536; 30001349; 30573684; 31209037; 31597105; 31928997; 32093423; 32357935; 32989256; 33503415; 33692124; 33820915; 33851958; 33857133; 33863777; 34508175; 34509474; 34676045; 34711990; 35348191; 35413091; 35768646; 35951367; 36563124; 36781846 212 5 12 -RB1 Rb Nuclear receptor co-regulator; Oncoprotein; Transcription, coactivator/corepressor; Tumor suppressor P06400 5925 13q14.2 human S249-p 447975 AVIPINGsPRTPRRG activity, induced; protein degradation; acetylation; molecular association, regulation; ubiquitination; activity, inhibited; phosphorylation cell cycle regulation; carcinogenesis, induced; cell growth, inhibited; transcription, induced; transcription, altered; signaling pathway regulation; cell growth, induced; apoptosis, inhibited; transcription, inhibited BRD4(DISRUPTS); E2F1(DISRUPTS); E2F1(INDUCES); EID1(DISRUPTS); HDAC5(DISRUPTS) 17599043; 17996702; 22279936; 27642049; 33419772; 35023164; 36274096; 36637424 19 45 86 -GLI2 GLI2 C2H2-type zinc finger protein; Oncoprotein; Transcription factor P10070 2736 2q14.2 human T1546-p 1874115100 QNSSRLTtPRNSLTL protein stabilization carcinogenesis, induced; cell growth, induced; transcription, induced 34267186 1 1 0 inhibits ubiquitination -HNRNPK hnRNP K RNA splicing; RNA-binding; Spliceosome P61978 3190 9q21.32 human S379-p 483629 SYAGGRGsYGDLGGP cell cycle regulation; cell motility, inhibited 31110205 2 48 4 downregulates Twist, upregulates MMP12, upregulates and stabilizes beta catenin -Tp53 p53 Activator; DNA-binding; Motility/polarity/chemotaxis; Nuclear receptor co-regulator; Transcription factor; Tumor suppressor P02340 22059 11 B3|11 42.83 cM mouse S37-p 1869726220 PPEDILPsPHCMDDL phosphorylation 15794754 4 1 0 S37A mutant abrogates the constitutive phosphorylation at S18 (S15 in human) in the BVE system, but not in the mamalian in vitro expression system -AMOTL2 AMOTL2 Cell adhesion Q9Y2J4 51421 3q22.2 human S759-p 477928 SSSQRAAsLDSVATS molecular association, regulation cell motility, induced; cell growth, induced; transcription, induced YAP1(DISRUPTS) 25998128 1 21 2 -TKT TKT Carbohydrate Metabolism - pentose phosphate pathway; EC 2.2.1.1; Transferase P29401 7086 3p21.1 human T287-p 452283 SKKKILAtPPQEDAP molecular association, regulation; ubiquitination; enzymatic activity, induced carcinogenesis, induced; cell motility, induced; cell growth, induced; transcription, induced; signaling pathway regulation FBXL6(INDUCES) 37653031 1 31 3 regulates the FBXL6-TKT-ROS-mTOR pathway -KDR VEGFR2 EC 2.7.10.1; KINASE; Kinase, protein; Membrane protein, integral; Protein kinase, TK; Protein kinase, tyrosine (receptor) P35968 3791 4q12 human Y1214-p 447902 VCDPKFHyDNTAGIS molecular association, regulation; enzymatic activity, induced carcinogenesis, induced; cell motility, altered; cell motility, inhibited; cytoskeletal reorganization NCK1(INDUCES); Fyn(INDUCES) 14724572; 16966330; 20176926; 35081345 17 4 58 -DNM1L DRP1 Apoptosis; EC 3.6.5.5; Endoplasmic reticulum; Hydrolase; Microtubule-binding; Mitochondrial; Motor O00429 10059 12p11.21 human Y266-p 297110000 TDSIRDEyAFLQKKY Dynamin_M activity, induced 29022905 1 0 0 oxidative stress-induced cell death in primary cortical neuron; increased GTPase activity -GATA3 GATA3 Transcription factor P23771 2625 10p14 human R261-m2 56834500 KARSSTGrECVNCGA molecular association, regulation transcription, inhibited HSP60(INDUCES) 25861992 1 1 0 induce Il-5 transcription -PAX7 PAX7 DNA-binding; Oncoprotein; Transcription factor O42349 395942 chicken K85-sm 27850500 VSHGCVSkILCRYQE PAX cell differentiation, induced; transcription, induced 23247248 1 0 0 regulation of neural crest and muscle development -CAPZA1 CAPZA1 Actin-binding; Motility/polarity/chemotaxis P52907 829 1p13.2 human S9-p 457555 ADFDDRVsDEEKVRI molecular association, regulation; phosphorylation cytoskeletal reorganization PLEKHO1(INDUCES) 15831458 1 23 0 -TLN1 talin 1 Cytoskeletal; Motility/polarity/chemotaxis Q9Y490 7094 9p13.3 human S425-p 1984203 TMLEDSVsPKKSTVL protein stabilization; molecular association, regulation; ubiquitination cell motility, induced; cell adhesion, induced; cell motility, altered; cell adhesion, altered SMURF1(DISRUPTS) 19363486; 24793790 7 44 2 ?1 integrin activation in metastatic PCa cells -ETS2 Ets-2 DNA-binding; Oncoprotein; Transcription factor P15036 2114 21q22.2 human S220-p 30320500 PKGGLLDsMCPASTP protein degradation 24218572; 26871468 2 1 0 CDK10 mediated degradation -CD151 CD151 Membrane protein, integral; Membrane protein, multi-pass P48509 977 11p15.5 human K17-ub 4666604 TCGTVCLkYLLFTYN Tetraspanin protein degradation 18713730 1 0 0 cell surface downregulation of tetraspanins -Nfe2l2 NRF2 DNA-binding; Transcription factor Q60795 18024 2 C3|2 44.75 cM mouse S351-p 18258500 SRASPEHsVESSIYG protein degradation; molecular association, regulation BTRC(INDUCES) 21245377 1 0 0 -HSD17B10 HADH2 Amino Acid Metabolism - valine, leucine and isoleucine degradation; EC 1.1.1.178; EC 1.1.1.35; EC 1.1.1.51; Mitochondrial; Oxidoreductase Q99714 3028 Xp11.22 human K99-ac 1877232021 AGIAVASkTYNLKKG adh_short enzymatic activity, inhibited cell growth, inhibited RG9MTD1(DISRUPTS) 32703935; 32956445 2 0 0 formation of mt-tRNA splicing complex, regulated mitochondrial function, les cell resistance to stress and cell growth ; mt-tRNA splicing complex -Flot2 FLOT2 Cell adhesion Q9Z2S9 83764 10q25 rat Y124-p 1270904 TLTVEQIyQDRDQFA Band_7 cell motility, altered; cytoskeletal reorganization 17213334 1 1 0 -MAFA MAFA DNA-binding; Oncoprotein; Transcription factor; Tumor suppressor O57342 quail T113-p 456029 NPEALNLtPEDAVEA Maf_N cell differentiation, altered; transcription, altered 15963504 4 2 0 -TAX1BP1 TAX1BP1 iso2 Apoptosis Q86VP1-2 8887 7p15.2 human S593-p 12738639 NYKELKRsLENPAER molecular association, regulation; ubiquitination signaling pathway regulation TRAF2(INDUCES); TRAF6(INDUCES) 21765415 1 6 0 regulates NF-kB signaling; ; regulates interaction with A20 and Itch via TRAF2 and TRAF6 -MICAL2 MICAL2 Adaptor/scaffold; EC 1.14.13.- O94851 9645 11p15.3 human Y463-p 1875329208 INKNFEQyTLDPGTR carcinogenesis, induced; cell motility, induced; cell growth, induced; cytoskeletal reorganization 34750518 1 1 0 -Sirt1 SIRT1 Apoptosis; DEACETYLASE; Deacetylase; EC 3.5.1.-; Nuclear receptor co-regulator Q923E4 93759 10|10 B4 mouse S683-p 9993600 EEPLEDEsEIEEFYN enzymatic activity, induced apoptosis, inhibited 19680552 1 0 0 deacetylates p53 K382 and NFkB-p65 -EP300 p300 ACETYLTRANSFERASE; Acetyltransferase; EC 2.3.1.48; Motility/polarity/chemotaxis; Nuclear receptor co-regulator; Transcription, coactivator/corepressor Q09472 2033 22q13.2 human R754-m1 1872472300 PPMGYGPrMQQPSNQ molecular association, regulation cell cycle regulation; DNA repair, induced; transcription, induced BRCA1(INDUCES) 21245169 1 0 0 -Tnni3 TNNI3 Actin-binding; Motility/polarity/chemotaxis; Motor P48787 21954 7 A1|7 2.61 cM mouse S24-p 448424 APVRRRSsANYRAYA Troponin-I_N activity, induced; activity, inhibited; protein conformation; phosphorylation cytoskeletal reorganization 12923217; 15507454; 15774859; 17010989; 17615373; 20083117; 22527640; 8530519 64 12 16 TNNI3 transgenic and gene transfer of S22/23D showed faster relaxation times. ; ROCK II induced desensitization to Ca++ and depression in maximal tension. -Nr0b2 NR0B2 Nuclear receptor; Nuclear receptor co-regulator; Transcription, coactivator/corepressor Q62227 23957 4 D2.3|4 66.25 cM mouse K122-ub 7596701 APVPSILkKILLEEA Hormone_recep protein degradation 19390091 1 0 0 -FOXO1 FOXO1A DNA-binding; Nuclear receptor co-regulator; Oncoprotein; Transcription factor Q12778 2308 13q14.11 human S287-p 478910 GQEGAGDsPGSQFSK intracellular localization transcription, altered 20061393 4 26 1 multiple site mutant (8A) -Egfr EGFR EC 2.7.10.1; KINASE; Kinase, protein; Membrane protein, integral; Oncoprotein; Protein kinase, TK; Protein kinase, tyrosine (receptor) Q01279 13649 11 A2|11 9.41 cM mouse Y1092-p 448057 AFLPVPEyVNQSVPK activity, induced; molecular association, regulation; enzymatic activity, induced; phosphorylation carcinogenesis, induced; carcinogenesis, altered; cell motility, induced; transcription, altered; signaling pathway regulation; cell growth, induced; cell differentiation, induced; apoptosis, inhibited; transcription, inhibited MUC4(INDUCES) 16123117; 21857648; 32197276; 34520454; 34610301; 34620174; 36323264; 36385375; 36624189 177 30 352 -WASF2 WAVE2 Actin-binding; Motility/polarity/chemotaxis Q9Y6W5 10163 1p36.11 human S489-p 6377640 SDSEDDSsEFDEDDW activity, inhibited cytoskeletal reorganization 19012317 1 0 1 -PIK3R1 PIK3R1 KINASE; Kinase, lipid; Motility/polarity/chemotaxis P27986 5295 5q13.1 human Y556-p 459303 LKKQAAEyREIDKRM PI3K_P85_iSH2 molecular association, regulation; enzymatic activity, induced cell motility, altered SHP-2(INDUCES); IRS1(INDUCES) 16306077 1 6 33 -FOXO3 FOXO3A Autophagy; DNA-binding; Oncoprotein; Transcription factor O43524 2309 6q21 human S321-p 453424 NSNASTVsGRLSPIM cell cycle regulation; transcription, inhibited SMAD4(INDUCES); SMAD3(INDUCES) 21532621; 33828192 9 0 0 Regulate cellular senescence in HaCaT cells -SNAI1 Snail1 C2H2-type zinc finger protein; Transcription factor O95863 6615 20q13.13 human T203-p 21400402 QGHVRTHtGEKPFSC activity, induced; protein stabilization; intracellular localization cell cycle regulation; carcinogenesis, induced; cell motility, induced; cell growth, induced; cell motility, altered; transcription, induced; transcription, altered 21952048; 30800215; 34335956 3 0 1 -RBL2 Rb-like 2 Transcription, coactivator/corepressor; Tumor suppressor Q08999 5934 16q12.2 human T694-p 449730 DSPSDGGtPGRMPPQ molecular association, regulation cell cycle regulation E2F4(DISRUPTS) 11157749 3 5 1 -Tfeb TFEB DNA-binding; Transcription factor Q9R210 21425 17 C|17 23.99 cM mouse S466-p 4785142 KASSRRSsFSMEEGD DUF3371 protein stabilization; intracellular localization autophagy, inhibited; transcription, induced 23599343; 28165011 4 20 2 Cellular clearance inhibited -NR4A1 Nur77 Apoptosis; DNA-binding; Nuclear receptor P22736 3164 12q13.13 human S351-p 447942 GRRGRLPsKPKQPPD activity, inhibited; phosphorylation cell motility, induced; cell growth, induced; apoptosis, induced; cytoskeletal reorganization; transcription, inhibited 11274386; 16434970; 26155943 11 4 0 Akt inhibits MEKK1-mediated nuclear export of Nur77 by phosphorylating S351. ; dephosphorylation of S351 is required for increase cell growth, cell motility, monolayer permeability and formation of actin stress fibers. -GAB2 GAB2 Adaptor/scaffold Q9UQC2 9846 11q14.1 human Y476-p 450051 GDNSQSVyIPMSPGA molecular association, regulation PIK3R1(INDUCES) 11334882 1 3 193 -NEK2 NEK2 EC 2.7.11.1; KINASE; Kinase, protein; Nucleolus; Protein kinase, Other; Protein kinase, Ser/Thr (non-receptor) P51955 4751 1q32.3 human S171-p 12574604 RILNHDTsFAKTFVG Pkinase enzymatic activity, induced 17197699 1 5 0 -HNRNPK hnRNP K RNA splicing; RNA-binding; Spliceosome P61978 3190 9q21.32 human R256-m2 6742804 RPVGFPMrGRGGFDR molecular association, regulation translation, inhibited RPS19(INDUCES) 33660773 2 4 1 suppression of ALOX15 mRNA translation initiation -H3C1 H3 DNA-binding P68431 8350 6p22.2 human K9-me 1668801 RTKQTARkSTGGKAP Histone molecular association, regulation; acetylation; intracellular localization; methylation; phosphorylation chromatin organization, altered; transcription, altered; transcription, inhibited DNA(INDUCES); DNA(DISRUPTS) 10949293; 11779497; 12208844; 12482974; 16774942; 17646159; 19010785; 32528962 27 1 0 -MAF MAF Cell development/differentiation; DNA-binding; Oncoprotein; Transcription factor; Tumor suppressor O75444 4094 16q23.2 human K297-ub 56473800 KQKRRTLkNRGYAQS bZIP_Maf protein degradation cell growth, inhibited 26825710 1 0 0 -GYS1 GYS1 Carbohydrate Metabolism - starch and sucrose; EC 2.4.1.11; Transferase P13834 100008660 rabbit S653-p 448240 PSLSRHSsPHQSEDE Glycogen_syn enzymatic activity, inhibited 10909964 13 24 4 -Rasgrf2 RASGRF2 GEF; GEF, Ras P70392 19418 13 C3|13 47.43 cM mouse S737-p 2902208 LAVSRTSsPVRARKL RasGEF_N activity, induced; intracellular localization; phosphorylation 15128856 1 0 0 regulates phosphorylation of MEK and ERK -KCNJ3 GIRK1 Channel, potassium; Membrane protein, integral; Membrane protein, multi-pass P48549 3760 2q24.1 human S385-p 4706226 NSKERHNsVECLDGL activity, induced 19151997 3 4 1 -DTD1 DTD1 DNA replication; EC 3.1.-.-; Hydrolase Q8TEA8 92675 20p11.23 human S179-p 23112003 KTRAKGPsESSKERN molecular association, regulation cell cycle regulation; cell growth, induced MCM7(INDUCES); MCM3(DISRUPTS) 25258324 1 1 1 decreases DTD1 incorporation into HMW, supports DNA replication initiation -NTRK3 TrkC EC 2.7.10.1; KINASE; Kinase, protein; Membrane protein, integral; Protein kinase, TK; Protein kinase, tyrosine (receptor) Q16288 4916 15q25.3 human Y705-p 464876 FGMSRDVySTDYYRL PK_Tyr_Ser-Thr carcinogenesis, induced; cell growth, induced; signaling pathway regulation 10702799 1 2 46 -RELA NFkB-p65 DNA-binding; Nuclear receptor co-regulator; Transcription factor Q04206 5970 11q13.1 human S311-p 449966 RTYETFKsIMKKSPF acetylation; molecular association, regulation; methylation carcinogenesis, induced; carcinogenesis, inhibited; transcription, induced; signaling pathway regulation SETD6(INDUCES); HDAC5(DISRUPTS) DNA(INDUCES) 21515635; 22205033; 23100252; 26729520; 32416562; 33864076; 34230209; 35265200 17 2 1 inhibits deacetylation of itself -Ptprn PTPRN Membrane protein, integral; Motility/polarity/chemotaxis; Receptor protein phosphatase, tyrosine Q60673 19275 1 C4|1 38.64 cM mouse K754-sm 12004423 DHARIKLkVESSPSR Y_phosphatase molecular association, regulation transcription, inhibited STAT5A(DISRUPTS) 16622421 1 0 0 binding to STAT5 prevents STAT5 dephosphorylation -Unc93b1 UNC93B1 Cell surface; Membrane protein, integral; Membrane protein, multi-pass Q8VCW4 54445 19|19 A mouse S547-p 3212115 RYLEEDNsDESDMEG molecular association, regulation signaling pathway regulation syntenin(INDUCES) 31546246 1 25 4 inhibits TLR7 signaling -TAB2 TAB2 Adaptor/scaffold Q9NYJ8 23118 6q25.1 human K562-sm 1877015600 KKKLDKLkSEVNEME molecular association, regulation transcription, inhibited; signaling pathway regulation 33184450 1 0 0 inhibition of TRAF6/TAB2/TAK1 complex and downstream MAPK and NF-?B pathway -CDCA5 CDCA5 Cell cycle regulation Q96FF9 113130 11q13.1 human S139-p 20727378 DARDLEMsKKVRRSY Sororin activity, inhibited cell cycle regulation SCC-112(DISRUPTS) 23901111 1 1 0 -OVAL ovalbumin P01012 396058 chicken S345-p 22689701 AGREVVGsAEAGVDA Serpin protein stabilization 23316083 2 0 0 -KHSRP KHSRP RNA-binding Q92945 8570 19p13.3 human T692-p 458387 QAAYYGQtPGPGGPQ RNA stability, altered 16364914 1 0 0 inhibits degradation of myogenic transcripts during myoblast differentiation -GABBR1 GABBR1 GPCR, family 3; Membrane protein, integral; Membrane protein, multi-pass; Receptor, GPCR Q9UBS5 2550 6p22.1 human K905-ub 54191600 LEKIIAEkEERVSEL protein degradation; ubiquitination 26817839 1 0 0 -CTNNB1 CTNNB1 Actin-binding; Cell adhesion; Motility/polarity/chemotaxis; Nuclear receptor co-regulator; Oncoprotein; Transcription factor P35222 1499 3p22.1 human Y670-p 469563 SEDKPQDyKKRLSVE activity, induced; molecular association, regulation; intracellular localization cell growth, induced; transcription, induced; cell growth, altered LEF-1(DISRUPTS); Met(DISRUPTS); CDH1(DISRUPTS) 16952352; 21423209 3 1 15 -KEAP1 KEAP1 Endoplasmic reticulum; Motility/polarity/chemotaxis; Transcription regulation; UBIQUITIN LIGASE; Ubiquitin conjugating system Q14145 9817 19p13.2 human S104-p 1875847402 KVVLASSsPVFKAMF BTB molecular association, regulation PIN1(INDUCES) 34918396 1 0 0 -FZD6 FZD6 GPCR, Fz/Smo family; Membrane protein, integral; Membrane protein, multi-pass; Receptor, GPCR O60353 8323 8q22.3 human S648-p 1275585104 SVSESARsEGRISPK intracellular localization 30309985 1 1 0 localized in the plasma membrane -CDK9 CDK9 Cell cycle regulation; EC 2.7.11.22; EC 2.7.11.23; KINASE; Kinase, protein; Nuclear receptor co-regulator; Protein kinase, CMGC; Protein kinase, Ser/Thr (non-receptor) P50750 1025 9q34.11 human K44-ac 478252 RHRKTGQkVALKKVL Pkinase molecular association, regulation; intracellular localization; enzymatic activity, inhibited; phosphorylation transcription, induced; transcription, inhibited Other(INDUCES) 17452463; 18250157 3 1 0 induces ATP binding, inhibits phosphorylation of RNA POL II; induces phosphorylation of POLII -CAVIN1 PTRF Transcription initiation complex Q6NZI2 284119 17q21.2 human K296-ac 1873356108 KLKTSRDkLRKSFTP PTRF_SDPR molecular association, regulation; intracellular localization HSL(INDUCES) 28559430 1 1 0 induces lipolysis -CYP19A1 CYP19A1 EC 1.14.14.14; Lipid Metabolism - androgen and estrogen; Oxidoreductase P11511 1588 15q21.2 human Y361-p 10433800 KVMENFIyESMRYQP p450 protein degradation; enzymatic activity, induced 19556341; 31652308 2 1 0 -IRF3 IRF3 DNA-binding; Transcription factor Q14653 3661 19q13.33 human K313-ub 56403901 GPDGEVPkDKEGGVF IRF-3 protein degradation; ubiquitination; intracellular localization autophagy, induced; apoptosis, induced CALCOCO2(INDUCES) 27178468; 32476569; 33513265 3 0 0 -Scn2a SCN2A Channel, sodium; Membrane protein, integral; Membrane protein, multi-pass P04775 24766 3q21 rat Y1893-p 1046201 SNPSKVSyEPITTTL molecular association, regulation; activity, inhibited Fyn(INDUCES) 17959797 1 1 1 -OGG1 OGG1 DNA repair, damage; Deoxyribonuclease; EC 4.2.99.18; Lyase O15527 4968 3p25.3 human S280-p 10036105 HIAQRDYsWHPTTSQ HhH-GPD enzymatic activity, inhibited 19674107 1 0 0 -IBTK IBTK Protein kinase, regulatory subunit Q9P2D0 25998 6q14.1 human S1203-p 15483703 LHSVSSKsFRDFLLE activity, induced; molecular association, regulation; intracellular localization; enzymatic activity, induced Btk(DISRUPTS) 21482705 1 6 0 regulation of the Btk:IBTK complex, induce calcium mobilization and NFkB activation -CMAS CMAS Carbohydrate Metabolism - amino sugar and nucleotide sugar; EC 2.7.7.43; Transferase Q8NFW8 55907 12p12.1 human K399-m1 58123201 DACSTAQkAVGYICK molecular association, regulation L3MBTL iso4(INDUCES) 23583077 0 1 0 -Pxn PXN Adaptor/scaffold; Cell adhesion; Cytoskeletal; Motility/polarity/chemotaxis Q8VI36 19303 5 F|5 56.1 cM mouse Y118-p 448604 AGEEEHVySFPNKQK Paxillin activity, induced; molecular association, regulation; phosphorylation carcinogenesis, induced; apoptosis, altered; cell motility, induced; cell adhesion, induced; cell growth, induced; cell motility, altered; apoptosis, inhibited; cell adhesion, altered; cytoskeletal reorganization RASA1(INDUCES); Vinculin(INDUCES) 12446743; 15107421; 15138291; 20308429; 30604146; 33711252; 36207442; 36997926 83 79 2519 -MYCN N-Myc DNA-binding; Oncoprotein; Transcription factor P04198 4613 2p24.3 human T58-p 448223 KKFELLPtPPLSPSR Myc_N protein degradation; molecular association, regulation; ubiquitination; intracellular localization TRIM32(INDUCES); AurA(INDUCES) 19111882; 25100564; 25175806 7 22 17 Phosphorylation is required and MG-132 protects N-Myc from degradation -Prkca PKCA EC 2.7.11.13; KINASE; Kinase, protein; Oncoprotein; Protein kinase, AGC; Protein kinase, Ser/Thr (non-receptor) P20444 18750 11 E1|11 70.8 cM mouse S657-p 448597 QSDFEGFsYVNPQFV Pkinase_C molecular association, regulation cytoskeletal reorganization; signaling pathway regulation fascin(INDUCES) 18851840; 30683702 28 4 2 -SLC12A2 NKCC1 Membrane protein, integral; Membrane protein, multi-pass; Transporter; Transporter, SLC family P55011 6558 5q23.3 human T212-p 455545 TNTYYLRtFGHNTMD AA_permease_N activity, induced; enzymatic activity, induced 12145304; 12145305; 16669787; 22032326 20 15 13 -Slc2a2 GLUT2 Membrane protein, integral; Membrane protein, multi-pass; Transporter; Transporter, SLC family P12336 25351 2q24 rat S489-p 451344 VPETKGKsFDEIAAE Sugar_tr activity, inhibited 8626492 1 0 0 Phosphorylation reduces the initial rate of 3-O-methyl glucose uptake. -Hdac7 HDAC7 DEACETYLASE; Deacetylase; EC 3.5.1.98; Hydrolase Q8C2B3 56233 15|15 F1 mouse S178-p 455620 FPLRKTVsEPNLKLR molecular association, regulation; intracellular localization 14-3-3 epsilon(DISRUPTS) 16956611; 21399638 9 34 53 phosphorylation excludes HDAC7 from nucleus -SUGT1 SUGT1 Cell cycle regulation; Ubiquitin conjugating system Q9Y2Z0 10910 13q14.3 human S281-p 486562 KNLYPSSsPYTRNWD protein stabilization; molecular association, regulation; intracellular localization cell cycle regulation RNF41(INDUCES) 21864708; 28696259 2 4 9 -XRCC5 Ku80 DNA-binding; EC 3.6.1.-; EC 3.6.4.-; Helicase; Nuclear receptor co-regulator; Nucleolus; RNA-binding P13010 7520 2q35 human K155-ub 15391493 DIIIHSLkKCDISLQ Ku_N molecular association, regulation DNA repair, induced DNA(DISRUPTS) 27895153 1 2 1 -ARHGEF6 ARHGEF6 GEF; GEF, Rac/Rho; Motility/polarity/chemotaxis Q15052 9459 Xq26.3 human S488-p 452424 LSASPRMsGFIYQGK PH activity, induced cell motility, induced; cell growth, induced 25694429 1 80 5 GEF -Gsk3b GSK3B EC 2.7.11.1; EC 2.7.11.26; KINASE; Kinase, protein; Protein kinase, CMGC; Protein kinase, Ser/Thr (non-receptor) Q9WV60 56637 16|16 B3 mouse S21-p 456055 CKPVQQPsAFGSMKV cell differentiation, induced; transcription, induced 34140410 7 1 9 inhibits degradation of ?-catenin -WWOX WWOX Apoptosis; EC 1.1.1.-; Oxidoreductase; Tumor suppressor Q9NZC7 51741 16q23.1-q23.2 human S14-p 454203 AGLDDTDsEDELPPG phosphorylation carcinogenesis, induced; cell motility, induced; cell growth, induced; apoptosis, inhibited; signaling pathway regulation 31752354 2 26 6 pS14-WWOX7-21 peptide treatment increased phosphorylation of Erk1, cell growth (4T1 cells & mice) and metastasis (in mice) -TTC3 TTC3 Cell development/differentiation; EC 6.3.2.-; EC 6.3.2.19; Ligase; UBIQUITIN LIGASE; Ubiquitin conjugating system; Ubiquitin ligase P53804 7267 21q22.13 human S378-p 12473003 AYTPRSLsAPIFTTS ubiquitination; enzymatic activity, induced cell cycle regulation 20059950 1 2 0 facilitates proteasomal degradation of Akt1 -CHEK2 Chk2 EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, CAMK; Protein kinase, Ser/Thr (non-receptor); Tumor suppressor O96017 11200 22q12.1 human S372-p 17534900 KITDFGHsKILGETS Pkinase intracellular localization 20713355 1 1 0 chromatin targeting of S372, S379, T389, singly and T383/389, T378/S379 -Podxl PODXL Cell adhesion; Membrane protein, integral; Motility/polarity/chemotaxis Q9WTQ2 192181 4q22 rat S415-p 21514209 GCCHQRIsQRKDQQR CD34_antigen molecular association, regulation; intracellular localization; enzymatic activity, inhibited; activity, inhibited cytoskeletal reorganization Ezrin(DISRUPTS) 21945805 1 1 0 prevents RhoA and Ezrin activation, alters actin cytoskeleton -Pias2 PIAS2 EC 6.3.2.-; Nuclear receptor co-regulator; SUMO LIGASE; SUMO conjugating system; SUMO ligase; Transcription, coactivator/corepressor Q6AZ28 83422 18q12.3 rat S113-p 464653 STSIAPHsPSSPVAS transcription, altered 16713578 1 0 0 important for Elk1-mediated transcriptional activation -STX17 STX17 Membrane protein, integral; Membrane protein, multi-pass; Vesicle P56962 55014 9q31.1 human Y157-p 479165 SQSLTQIyALPEIPQ molecular association, regulation COPB1(DISRUPTS) 23006999 1 0 1 regulates STX17 dependent membrane trafficking -H1-4 H1E DNA-binding P10412 3008 6p22.2 human K26-m2 6742808 PVKKKARkSAGAAKR molecular association, regulation L3MBTL iso4(INDUCES); CBX3(INDUCES) 19144645 1 1 0 -Lsr LISCH iso2 Membrane protein, integral; Receptor, misc. Q99KG5-2 54135 7|7 B1 mouse Y237-p 463761 CCCPEALyAAGKAAT intracellular localization 31574128 1 5 33 inhibits epithelial barrier function -Mapk3 ERK1 EC 2.7.11.24; KINASE; Kinase, protein; Protein kinase, CMGC; Protein kinase, Ser/Thr (non-receptor) P21708 50689 1q36 rat T208-p 3949243 FLTEYVAtRWYRAPE Pkinase enzymatic activity, induced 26658610 2 13 31 -Prkd1 PRKD1 Autophagy; EC 2.7.11.13; KINASE; Kinase, protein; Motility/polarity/chemotaxis; Protein kinase, CAMK; Protein kinase, Ser/Thr (non-receptor) Q62101 18760 12|12 B3 mouse S748-p 448590 GEKSFRRsVVGTPAY Pkinase activity, induced; enzymatic activity, induced 10473617; 10867018; 12407104; 15084589; 15590638; 15623513; 34478715 56 49 53 -GMNN Geminin Cell cycle regulation; Motility/polarity/chemotaxis O75496 51053 6p22.3 human Y150-p 33402208 EVAEHVQyMAELIER Geminin protein stabilization carcinogenesis, induced; cell growth, induced; apoptosis, inhibited 24789045 1 0 0 induces aneuploidy, promotes transformation -Myb Myb DNA-binding; Oncoprotein; Transcription factor P06876 17863 10 A3|10 9.75 cM mouse K499-sm 486351 EDLQDVIkQESDESG Cmyb_C protein stabilization; intracellular localization transcription, inhibited 11779867; 16162816; 17077080 5 0 0 slight increase in conjugation of two and three molecules of SUMO-2 with S528A phospho-mutant under stress -Kcnb1 Kv2.1 Channel, cation; Channel, ligand-gated; Channel, potassium; Membrane protein, integral; Membrane protein, multi-pass P15387 25736 3q42 rat S804-p 473562 ESSPLPTsPKFLRPN activity, induced; molecular association, regulation; intracellular localization apoptosis, induced; signaling pathway regulation CAMK2A(INDUCES); STX1B(INDUCES) 17360683; 23918396 8 8 0 -BANF1 BAF DNA-binding O75531 8815 11q13.1 human T3-p 7105313 _____MTtSQKHRDF BAF molecular association, regulation; intracellular localization; protein conformation DNA(INDUCES); DNA(DISRUPTS) 16495336; 24600006; 24945635; 33744941; 36402223 6 9 0 -PEAK3 PEAK3 Q6ZS72 374872 19p13.3 human Y24-p 1876371802 TWSTQPTySNLGQIR molecular association, regulation carcinogenesis, induced; cell motility, induced; cell growth, induced; signaling pathway regulation GRB2(INDUCES); CDK6(INDUCES) 35192416 1 1 0 regulates cell invasion through the PEAK3/Grb2/ASAP1 signaling axis -Ppp1ca PPP1CA EC 3.1.3.16; Nucleolus; PHOSPHATASE; Protein phosphatase, Ser/Thr (non-receptor) P62137 19045 19|19 A mouse T320-p 448686 NPGGRPItPPRNSAK intracellular localization 9122166 24 43 98 -SNCA SNCA Adaptor/scaffold P37840 6622 4q22.1 human Y39-p 3546424 KTKEGVLyVGSKTKE Synuclein protein stabilization; molecular association, regulation; phosphorylation apoptosis, altered HSP90B(DISRUPTS); SKP1A(DISRUPTS); SNCA(DISRUPTS); DRBP1(INDUCES); HSC70(DISRUPTS) 18238775; 24412932; 28636593; 31802003; 36690898 9 4 11 decreases phosphorylation of S129 SNCA -SCRIB Scribble Cell adhesion; Motility/polarity/chemotaxis Q14160 23513 8q24.3 human S1508-p 480131 WRAARMKsLEQDALR intracellular localization cell motility, induced; cell adhesion, induced 33583073 2 49 80 -Ceacam1 CEACAM1 Cell adhesion; Immunoglobulin superfamily; Membrane protein, integral; Motility/polarity/chemotaxis P16573 81613 1q21 rat S503-p 448536 QQSKRPTsASSSPTE activity, induced; receptor internalization, altered; intracellular localization 10581007; 11850617; 7518458; 7626603 11 2 0 site directed mutagenesis of this site and T502 nearly abrogates the bile acid efflux activity of CEACAM1; increases insulin receptor internalization and insulin clearance from blood; Phosphorylation of CEACAM1 induces Ca2+/Mg2+-dependent ecto ATPase activity. -Csf2rb CSF2RB Membrane protein, integral; Receptor, cytokine P26955 12983 15 E1|15 37.36 cM mouse Y595-p 450103 SFDFNGPyLGPPQSH molecular association, regulation cell growth, altered SHC1(INDUCES); PIK3R1(INDUCES) 16437163 12 0 0 Phosphorylation of Y595 and S603 are exclusive. Y595 phosphorylation induces binding to Shc and prevents binding to 14-3-3. -PPP1R2 PPP1R2 Inhibitor; Motility/polarity/chemotaxis; Protein phosphatase, regulatory subunit P41236 5504 3q29 human S87-p 449054 GDDEDACsDTEATEA IPP-2 intracellular localization 9405437 4 15 4 Phosphorylation is required for nuclear localization during S phase. -ZC3HC1 NIPA Cell cycle regulation; Ubiquitin conjugating system Q86WB0 51530 7q32.2 human S370-p 483745 RPEPEAAsPTTRTRP molecular association, regulation; intracellular localization cell growth, induced NPM-ALK(DISRUPTS) 31434245 2 37 18 -CLDN2 Claudin-2 Cytoskeletal; Membrane protein, integral; Membrane protein, multi-pass P57739 9075 Xq22.3 human S208-p 21690001 QPLATRSsPRPGQPP intracellular localization 24907662 2 4 0 decreased nuclear and increased cytoplasmic localization -P2ry2 P2Y2 GPCR, family 1; Membrane protein, integral; Membrane protein, multi-pass; Receptor, GPCR; Receptor, misc. P41232 29597 1q32 rat S354-p 2909202 RKDLSISsDDSRRTE receptor internalization, induced 31289122 2 0 0 Regulates ATP induced calcium response -TTK TTK Cancer Testis Antigen (CTA); EC 2.7.12.1; KINASE; Kinase, protein; Protein kinase, Other; Protein kinase, dual-specificity (non-receptor) P33981 7272 6q14.1 human T210-p 41389703 LSASTVLtAQESFSG intracellular localization; enzymatic activity, induced 26119734 1 1 0 regulates spindle assembly checkpoint and recruitment of SAC proteins -MARCKS MARCKS Actin-binding; Motility/polarity/chemotaxis P29966 4082 6q21 human S159-p 447786 KKKKKRFsFKKSFKL MARCKS exocytosis, inhibited 21762971 26 15 10 induce MUC5AC secretion by cold -AHR AHR DNA-binding; Transcription factor P35869 196 7p21.1 human S727-p 1874101930 PMGSFEPsPYPTTSS protein degradation; ubiquitination autophagy, induced; transcription, induced 34198826 1 0 0 -SMAD3 SMAD3 DNA-binding; Nuclear receptor co-regulator; Transcription factor P84022 4088 15q22.33 human K20-ac 1881518201 KRLLGWKkGEQNGQE carcinogenesis, induced; transcription, induced 34392614 1 0 0 upregulates immune response-related cytokines, recruits myeloid-derived suppressor cells and promotion of metastasis -DGCR8 DGCR8 Nucleolus; RNA processing; RNA-binding Q8WYQ5 54487 22q11.21 human T125-p 59186600 VKISVSFtESCRSKD protein stabilization 24239349 0 1 0 -BECN1 beclin 1 Adaptor/scaffold; Autophagy; Membrane protein, peripheral Q14457 8678 17q21.31 human T108-p 29606706 GEASDGGtMENLSRR BH3 molecular association, regulation; intracellular localization apoptosis, induced; autophagy, inhibited Bcl-2(INDUCES); beclin 1(INDUCES); Bcl-xL(INDUCES) 24141421 1 1 0 -DNM1 DYN1 EC 3.6.5.5; Hydrolase; Microtubule-binding; Motility/polarity/chemotaxis; Motor; Vesicle Q05193 1759 9q34.11 human S774-p 450205 SVPAGRRsPTSSPTP activity, induced; activity, inhibited endocytosis, induced; endocytosis, inhibited 26139537; 29695509 14 34 21 -CALD1 Caldesmon Actin-binding P12957 373965 chicken S702-p 456707 GLKVGVSsRINEWLT Caldesmon molecular association, regulation Calmodulin(DISRUPTS) 20858431 5 1 0 -Grin2a NMDAR2A Channel, ligand-gated; Membrane protein, integral; Membrane protein, multi-pass Q00959 24409 10q11 rat S1416-p 455790 ASYCSRDsRGHSDVY NMDAR2_C molecular association, regulation CAMK2A(DISRUPTS) 11104776 1 0 0 -CEP250 CEP250 Cell cycle regulation Q9BV73 11190 20q11.22 human S2064-p 1869636100 REQLLEKsLAQRVQE cytoskeletal reorganization 32606248 1 0 0 regulates centrosome-seperation -OPRD1 DOR-1 GPCR, family 1; Membrane protein, integral; Membrane protein, multi-pass; Receptor, GPCR P41143 4985 1p35.3 human S363-p 448550 RVTACTPsDGPGGGA receptor inactivation, induced; receptor internalization, induced; receptor desensitization, altered; receptor internalization, altered 10893226; 17322005; 32444688 12 1 0 -Sting1 STING Apoptosis; Endoplasmic reticulum; Membrane protein, integral; Membrane protein, multi-pass; Mitochondrial Q3TBT3 72512 18 B2|18 mouse K337-sm 59117705 RHIRQEEkEEVTMNA activity, induced; protein stabilization STING(INDUCES) 27637147 1 0 0 regulates the stability of activated cGas; K337 of Sting promotes its stability, activation, oligomerization, and Irf3 recruitment. -UGT2B7 UGT2B7 Carbohydrate Metabolism - ascorbate and aldarate; Carbohydrate Metabolism - pentose and glucuronate interconversions; Carbohydrate Metabolism - starch and sucrose; Cofactor and Vitamin Metabolism - porphyrin and chlorophyll; Cofactor and Vitamin Metabolism - retinol; EC 2.4.1.17; Lipid Metabolism - androgen and estrogen; Membrane protein, integral; Transferase; Xenobiotic Metabolism - drug metabolism - cytochrome P450; Xenobiotic Metabolism - drug metabolism - other enzymes; Xenobiotic Metabolism - metabolism by cytochrome P450 P16662 7364 4q13.2 human Y236-p 7378200 MKKWDQFySEVLGRP UDPGT enzymatic activity, induced 19289110 2 0 0 -CANX Calnexin Calcium-binding; Endoplasmic reticulum; Membrane protein, integral; Motility/polarity/chemotaxis P24643 dog S555-p 456359 KLEEKQKsDAEEDGG molecular association, regulation; intracellular localization PACS2(DISRUPTS) 18417615 3 88 73 -PAK4 PAK4 EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, STE; Protein kinase, Ser/Thr (non-receptor) O96013 10298 19q13.2 human S291-p 2192537 PGPPGPRsPQREPQR carcinogenesis, induced; cell growth, induced; signaling pathway regulation 34262144 1 29 5 ?-catenin/c-Myc, MEK/ERK signaling pathway -Mrtfa MKL1 Oncoprotein; Transcription, coactivator/corepressor Q8K4J6 223701 15|15 E1 mouse T488-p 469405 KFGSTGStPPVSPTP transcription, induced 33171330 1 43 24 regulates the expression of IL-6; regulates re-endothelialization -Egfr EGFR EC 2.7.10.1; KINASE; Kinase, protein; Membrane protein, integral; Oncoprotein; Protein kinase, TK; Protein kinase, tyrosine (receptor) Q01279 13649 11 A2|11 9.41 cM mouse Y1197-p 448060 PTAENAEyLRVAPPS carcinogenesis, induced; cell motility, induced; cell growth, induced; apoptosis, inhibited; transcription, inhibited; signaling pathway regulation 16123117; 23652203; 34620174; 36323264; 36385375 106 59 1028 -KPNA2 KPNA2 Karyopherin; Nuclear import; Nucleoporin P52292 3838 17q24.2 human T9-p 11536044 STNENANtPAARLHR molecular association, regulation; intracellular localization cell cycle regulation; chromatin organization, altered NuMA-1(DISRUPTS); TPX2(DISRUPTS); KPNB1(DISRUPTS); KIFC1(DISRUPTS) 31434716 1 9 0 -CYCS CYCS Apoptosis; Mitochondrial; Oxidoreductase; PHOSPHATASE; Protein phosphatase, Ser/Thr (non-receptor) P00004 100053958 horse K87-ac 1186609 KMIFAGIkKKTERED Cytochrom_C enzymatic activity, induced 19645667 1 3 20 -ERBB4 HER4 EC 2.7.10.1; KINASE; Kinase, protein; Membrane protein, integral; Protein kinase, TK; Protein kinase, tyrosine (receptor) Q15303 2066 2q34 human Y1128-p 461025 EDSSTQRySADPTVF molecular association, regulation Src(INDUCES); STAT1(INDUCES) 18721752 0 1 1 -H2AC11 H2A.1 DNA-binding P0C0S8 8329 6p22.1 human K15-ac 55610201 GKARAKAkTRSSRAG Histone intracellular localization cell cycle regulation; DNA repair, induced 27153538 3 0 0 -RET Ret EC 2.7.10.1; KINASE; Kinase, protein; Membrane protein, integral; Oncoprotein; Protein kinase, TK; Protein kinase, tyrosine (receptor) P07949 5979 10q11.21 human Y1015-p 449894 MMVKRRDyLDLAAST transcription, altered; cell growth, altered 12444552; 14981541 12 0 0 -Irak1 IRAK1 EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, Ser/Thr (non-receptor); Protein kinase, TKL Q62406 16179 X A7.3|X 37.61 cM mouse K134-ub 2134713 AGDWSPRkLQSSAST protein degradation signaling pathway regulation 29038250 3 0 0 activation of TLR9 ligand-induced inflammatory signaling -Ifi204 IFI16 iso6 Transcription factor P0DOV2_VAR_I158S 15951 1 H3|1 80.63 cM mouse S158-p 1848001 STAQKRKsMREEETG intracellular localization 18165224 1 1 0 -USP22 USP22 Cell cycle regulation; DEUBIQUITINASE; EC 3.4.19.12; Nuclear receptor co-regulator; Protease; Transcription, coactivator/corepressor; Ubiquitin conjugating system; Ubiquitin-specific protease Q9UPT9 23326 17p11.2 human K129-ac 11316055 KDMEIIAkEEQRKAW molecular association, regulation; enzymatic activity, induced ataxin-7L3(INDUCES); GCN5(INDUCES) 23382074 1 1 0 -Abl1 Abl EC 2.7.10.2; KINASE; Kinase, protein; Oncoprotein; Protein kinase, TK; Protein kinase, tyrosine (non-receptor) P00520 11350 2 21.86 cM|2 B mouse Y226-p 450303 KRNKPTIyGVSPNYD phosphorylation; enzymatic activity, induced carcinogenesis, induced; translation, induced 10964922; 11847100; 12748290; 36044842 28 12 304 induces YB1 phosphorylation -Notch1 Notch 1 Membrane protein, integral; Motility/polarity/chemotaxis; Oncoprotein; Receptor, misc.; Transcription factor Q01705 18128 2 A3|2 18.91 cM mouse K1772-ac 18899503 VSEASKKkRREPLGE protein stabilization; ubiquitination 21499261 1 1 0 -SMAD3 SMAD3 DNA-binding; Nuclear receptor co-regulator; Transcription factor P84022 4088 15q22.33 human S423-p 448335 SPSIRCSsVS_____ activity, induced; intracellular localization; protein conformation carcinogenesis, induced; cell differentiation, induced; cell motility, altered; transcription, induced; transcription, altered; signaling pathway regulation 19115199; 21148321; 31995604; 34003249; 35075279; 36461015; 9380693 39 0 5 The triple mutants(S422/423/425A and S422/423/425D) were used in these experiments -DEF6 DEF6 GEF; GEF, Rac/Rho Q9H4E7 50619 6p21.31 human T595-p 5750922 WGSQGNRtPSPNSNE activity, induced; molecular association, regulation transcription, induced IP3R1(INDUCES) 28993769 1 5 30 TCR stimulation-induced activation of NFAT, IL2, and IFNG, FasLG, CTLA4 and CD25 transcription -RND3 RhoE G protein; G protein, monomeric; G protein, monomeric, Rho; Motility/polarity/chemotaxis P61587 390 2q23.3 human S240-p 27933601 LRKDKAKsCTVM___ molecular association, regulation; intracellular localization cell cycle regulation; cytoskeletal reorganization 14-3-3 beta(INDUCES); 14-3-3 zeta(INDUCES) 23622247; 32041905 2 1 0 -RBBP8 CtIP EC 3.1.-.-; Transcription, coactivator/corepressor Q99708 5932 18q11.2 human S723-p 4766312 EERKMNDsLEDMFDR cell cycle regulation; DNA repair, inhibited 30202980 1 13 0 supress DSB end resection -SUZ12 SUZ12 C2H2-type zinc finger protein; Oncoprotein; Transcription factor Q15022 23512 17q11.2 human S541-p 3208749 KRTKASMsEFLESED molecular association, regulation; ubiquitination EZH2(DISRUPTS) 25855382 1 8 0 -MRE11 MRE11A Cell cycle regulation; DNA repair, damage; DNA-binding; Deoxyribonuclease P49959 4361 11q21 human R587-m2 62978400 RGQNSASrGGSQRGR DNA repair, altered 15741314 1 1 0 -ERBB2 HER2 EC 2.7.10.1; KINASE; Kinase, protein; Membrane protein, integral; Oncoprotein; Protein kinase, TK; Protein kinase, tyrosine (receptor) P04626 2064 17q12 human T686-p 451817 QQKIRKYtMRRLLQE receptor internalization, altered; intracellular localization; enzymatic activity, inhibited; phosphorylation AP2A1(NOT_REPORTED); SHP-2(NOT_REPORTED) 18799465; 26676300; 9855018 6 1 0 -RRM1 RRM1 DNA replication; EC 1.17.4.1; Nucleotide Metabolism - purine; Nucleotide Metabolism - pyrimidine; Other Amino Acids Metabolism - glutathione; Oxidoreductase P23921 6240 11p15.4 human S559-p 31890671 PYETYEGsPVSKGIL Ribonuc_red_lgC activity, induced; molecular association, regulation; enzymatic activity, induced cell cycle regulation; carcinogenesis, altered RFA2(DISRUPTS) 32712628 1 1 0 regulation of DNA replication, dNTP levels and genomic stability; induce RNR activity -Cpt1a CPT1A EC 2.3.1.21; Lipid Metabolism - fatty acid; Membrane protein, integral; Membrane protein, multi-pass; Mitochondrial; Transferase P32198 25757 1q42 rat S747-p 479871 FSSPETDsHRFGKHL Carn_acyltransf enzymatic activity, induced 15247243 1 1 0 in vitro -NRIP1 RIP140 Nuclear receptor co-regulator; Transcription, coactivator/corepressor P48552 8204 21q11.2-q21.1 human K1154-sm 2798319 LGSVLTIkKESE___ NRIP1_repr_4 intracellular localization transcription, inhibited 18211901 1 0 0 -CHKA CHKA EC 2.7.1.32; EC 2.7.1.82; Kinase, other; Lipid Metabolism - glycerophospholipid P35790 1119 11q13.2 human Y197-p 21041606 RSLGPKLyGIFPQGR Choline_kinase molecular association, regulation; enzymatic activity, induced carcinogenesis, induced; cell growth, induced; transcription, induced; translation, induced EGFR(INDUCES) 21822308 1 1 0 increases CHKA protein levels -Bsn BSN Cytoskeletal O88778 29138 8q32 rat S2845-p 456576 KTLQRSLsDPKPLSP molecular association, regulation neural plasticity 14-3-3 eta(INDUCES) 23516560 2 18 1 -Arhgdia RhoGDI alpha Apoptosis; Cell adhesion; Cell development/differentiation; G protein regulator, misc.; Motility/polarity/chemotaxis Q5XI73 360678 10q32.3 rat S34-p 467490 YKPPAQKsIQEIQEL Rho_GDI molecular association, regulation cell growth, altered RAC1(DISRUPTS); CDC42 iso1(DISRUPTS) 19103160 5 28 0 in response to bFGF stimulation -NBN NBS1 Cell cycle regulation; DNA repair, damage O60934 4683 8q21.3 human K544-ac 487512 SKSHAAEkLRSNKKR phosphorylation cell cycle regulation; apoptosis, induced 17612497 2 3 19 inhibits phosphorylation at S343 -SHC1 SHC1 iso2 Adaptor/scaffold; Apoptosis; Mitochondrial; Motility/polarity/chemotaxis P29353-2 6464 1q21.3 human Y317-p 448511 ELFDDPSyVNVQNLD activity, induced; molecular association, regulation; phosphorylation cell differentiation, altered; cell growth, induced; cell motility, altered; apoptosis, inhibited; cytoskeletal reorganization; signaling pathway regulation; cell growth, altered SOS1(INDUCES); GRB2(INDUCES); SHIP(INDUCES); ZAP70(INDUCES); PIK3R1(INDUCES); VAV1(INDUCES) 10598576; 10891441; 12237775; 17537990; 9121430; 9566877; 9741627; 9813159 42 91 1971 Y317F Shc did not activate MAPK; ERK phosphorylation; f-actin cytoskeleton, chemotaxis.; activation of Ras/MAPK pathway -Dctn1 dynactin 1 Microtubule-binding; Motility/polarity/chemotaxis; Motor P28023 29167 4q34 rat S19-p 455515 TPSGSRMsTEASARP cytoskeletal reorganization 12119357 2 1 0 -STAT2 STAT2 DNA-binding; Transcription factor P52630 6773 12q13.3 human S381-p 1869778700 RKFNILTsNQKTLTP STAT_bind protein degradation; molecular association, regulation; ubiquitination carcinogenesis, inhibited; cell growth, inhibited; signaling pathway regulation FBXW7(INDUCES) 31843895 1 0 0 by FBXW7 interaction; FBXW7-STAT2 interaction regulate melanoma cell and colony growth -HDAC7 HDAC7 DEACETYLASE; Deacetylase; EC 3.5.1.98; Hydrolase Q8WUI4 51564 12q13.11 human S181-p 470131 NPLLRKEsAPPSLRR intracellular localization transcription, induced 17962809 2 24 18 -MCL1 MCL1 Apoptosis; Channel, misc.; Inhibitor; Membrane protein, integral; Mitochondrial Q07820 4170 1q21.2 human T156-p 59032200 ESGNNTStDGSLPST protein stabilization 27738316 1 0 0 -HNRNPK hnRNP K RNA splicing; RNA-binding; Spliceosome P61978 3190 9q21.32 human Y458-p 465997 LQNSVKQySGKFF__ molecular association, regulation RNA(DISRUPTS) 24642125 2 1 31 UCP2 mRNA -DVL2 DVL2 Adaptor/scaffold; Motility/polarity/chemotaxis O14641 1856 17p13.1 human S143-p 7320089 FHPNVSSsHENLEPE Dishevelled molecular association, regulation; intracellular localization cell cycle regulation; carcinogenesis, induced; apoptosis, inhibited; cytoskeletal reorganization; signaling pathway regulation PLK1(INDUCES) 22609948; 29426949; 31579410 4 3 1 Wnt/?-catenin signaling; 1) Ciliogenesis 2) Association with centrosome and basal bodies of cilia 3) Control homeostasis of DVL2 phosphorylation during ciliogenesis.; important for cilia resorption -PDHA1 PDHA1 Amino Acid Metabolism - valine, leucine and isoleucine biosynthesis; Carbohydrate Metabolism - butanoate; Carbohydrate Metabolism - citrate (TCA) cycle; Carbohydrate Metabolism - glycolysis and gluconeogenesis; Carbohydrate Metabolism - pyruvate; EC 1.2.4.1; Mitochondrial; Oxidoreductase P08559 5160 Xp22.12 human S293-p 448258 TYRYHGHsMSDPGVS E1_dh activity, induced; molecular association, regulation; acetylation; intracellular localization; enzymatic activity, inhibited; activity, inhibited carcinogenesis, induced; cell motility, induced; cell growth, induced; apoptosis, inhibited emerin(INDUCES) 11092882; 17065338; 17474719; 22289032; 25237928; 25243911; 25404640; 27357730; 27498883; 30700909; 30745576; 30797950; 30842661; 31088833; 32737469; 34667275; 35656815; 36071546; 7782287 96 108 675 -HNRNPUL1 E1B-AP5 RNA splicing; RNA-binding Q9BUJ2 11100 19q13.2 human R661-m1 15493497 NYRGGFNrSGGGGYS molecular association, regulation; intracellular localization NBS1(INDUCES) 26020839 1 4 18 ecruitment at sites of damage -KLF13 KLF13 C2H2-type zinc finger protein; DNA-binding Q9Y2Y9 51621 15q13.3 human K180-ac 460600 GCEKVYGkSSHLKAH zf-C2H2 molecular association, regulation DNA(DISRUPTS) 12758070 1 0 0 -TPR TPR Membrane protein, peripheral; Nuclear envelope; Nucleoporin; Oncoprotein P12270 7175 1q31.1 human S2073-p 468981 QAPRAPQsPRRPPHP molecular association, regulation; intracellular localization cell cycle regulation Mad1(INDUCES) 24938596 1 40 3 colocalization with chromatin during telophase -STING1 STING Apoptosis; Endoplasmic reticulum; Membrane protein, integral; Membrane protein, multi-pass; Mitochondrial Q86WV6 340061 5q31.2 human Y245-p 1869808400 RVYSNSIyELLENGQ TMEM173 molecular association, regulation; protein stabilization; intracellular localization; phosphorylation autophagy, inhibited; transcription, induced; signaling pathway regulation IRF3(INDUCES) 31527250; 32926474; 34933455 4 2 0 -Prkcd PKCD EC 2.7.11.13; KINASE; Kinase, protein; Nuclear receptor co-regulator; Protein kinase, AGC; Protein kinase, Ser/Thr (non-receptor); Protein kinase, tyrosine (non-receptor); Tumor suppressor P28867 18753 14 B|14 18.82 cM mouse Y523-p 450231 EILQGLKySFSVDWW Pkinase intracellular localization; phosphorylation; enzymatic activity, induced 27531930 4 0 0 phosphorylation of PKCG, localization of PKCD and PKCG -Ubtf UBF DNA-binding; Nucleolus; Transcription factor P25977 25574 10q32.1 rat S389-p 450170 INKKQTTsPASKKPS molecular association, regulation transcription, induced; transcription, altered POLR1A(INDUCES); TIF1B(INDUCES); p14ARF(DISRUPTS) 17182730; 20943765 4 3 1 -RAP1A RAP1A G protein; G protein, monomeric; G protein, monomeric, Ras; Motility/polarity/chemotaxis; Tumor suppressor P62834 5906 1p13.2 human S11-p 13310084 YKLVVLGsGGVGKSA Ras molecular association, regulation; protein conformation signaling pathway regulation RAF1(INDUCES) 30154518 1 6 1 affects MAPK pathway -RAP1B RAP1B G protein; G protein, monomeric; G protein, monomeric, Ras P61224 5908 12q15 human S180-p 22689703 GKARKKSsCQLL___ molecular association, regulation RAP1GDS1(DISRUPTS) 27760305 4 0 0 inhibits the prenylation of Rap1B -RAPGEF2 RAPGEF2 GEF; GEF, Ras; Motility/polarity/chemotaxis Q9Y4G8 9693 4q32.1 human S1248-p 30995200 AADSGRGsWTSCSSG protein degradation; molecular association, regulation; ubiquitination; enzymatic activity, inhibited carcinogenesis, induced; cell motility, induced BTRC(INDUCES) 24290981 1 0 0 inhibits Rap1 activity -PIP4K2B PIP4K2B Carbohydrate Metabolism - inositol phosphate; EC 2.7.1.149; Kinase, lipid; Motility/polarity/chemotaxis P78356 8396 17q12 human S326-p 470107 SYGTPPDsPGNLLSF PIP5K enzymatic activity, inhibited 16949365 1 11 13 -RUNX2 AML3 DNA-binding; Transcription factor Q13950 860 6p21.1 human S378-p 1867984202 SDPRQFPsISSLTES cell differentiation, inhibited; transcription, inhibited 30910359 1 1 0 in C2C12 cells -Akap12 AKAP12 Adaptor/scaffold Q5QD51 83425 1q11 rat S515-p 469988 SSGLKKLsGKKQKGK molecular association, regulation cell cycle regulation CCNE1(DISRUPTS); CCND1(DISRUPTS) 10982843; 11820772 2 1 0 shown with PKC phosphorylated and nonphosphorylated AKAP12; in vivo permeable peptide/phosphopeptide experiments -GABRB3 GABRB3 Channel, chloride; Channel, ligand-gated; Membrane protein, integral; Membrane protein, multi-pass; Transporter; Transporter, ion channel P28472 2562 15q12 human S433-p 450246 THLRRRSsQLKIKIP Neur_chan_memb receptor internalization, inhibited apoptosis, inhibited 24513087 13 0 3 -TET3 TET3 EC 1.14.11.n2; Oxidoreductase O43151 200424 2p13.1 human K994-ub 38497601 SMYFNGCkYARSKTP Tet_JBP intracellular localization; enzymatic activity, induced 25557551 1 0 0 -BCR Bcr EC 2.7.11.1; GAP; GAP, Rac/Rho; GEF, Rac/Rho; KINASE; Kinase, protein; Oncoprotein; Protein kinase, Ser/Thr (non-receptor); Protein kinase, atypical P11274 613 22q11.23 human Y177-p 447792 ADAEKPFyVNVEFHH molecular association, regulation; phosphorylation carcinogenesis, induced; cell growth, induced; cell motility, altered; apoptosis, inhibited; cell growth, altered GPR89A(INDUCES); GRB2(INDUCES); Hck(DISRUPTS); ECSIT(INDUCES); PLCG1(INDUCES); SHP-2(INDUCES); USP15(INDUCES); SOS1(INDUCES); GAB1(INDUCES); GAB2(INDUCES) 12124177; 35574218; 8112292; 8955135; 9178913; 9407116; 9747873 14 30 1018 regulates phosphorylation of downstream proteins; Grb2 binding site regulates tyrosine phosphorylation of Gab2. -MDC1 MDC1 Cell cycle regulation Q14676 9656 6p21.33 human S218-p 4213800 PFAFNLNsDTDVEEG molecular association, regulation cell cycle regulation NBS1(INDUCES) 18678890 1 1 6 MDC1-NBS1 interaction regulates intra-S-phase checkpoint activation -VIM Vimentin Cytoskeletal; Motility/polarity/chemotaxis P08670 7431 10p13 human S34-p 455454 SRSYVTTsTRTYSLG Filament_head activity, induced carcinogenesis, induced; cell motility, induced; cytoskeletal reorganization; transcription, altered 33525953 3 10 0 Regulates VIF dynamics -HDAC1 HDAC1 DEACETYLASE; Deacetylase; EC 3.5.1.98; Hydrolase; Nuclear receptor co-regulator P56517 373961 chicken S410-p 3195752 KRISIRNsDKRISCD protein stabilization; molecular association, regulation transcription, induced MBD3(DISRUPTS); HDAC2(INDUCES); MTA1(DISRUPTS) 33596269 1 6 0 no effect on homodimerization -Rab3ip RAB3IP GEF; GEF, Rab Q62739 29885 7q22 rat S19-p 37039803 VNLASPTsPDLLGVC activity, induced; molecular association, regulation; protein conformation; enzymatic activity, induced exocytosis, induced RAB11A(DISRUPTS); RAB8A(INDUCES) 25535387 1 0 0 induces GEF activity of RAB3IP, induces RAB8 activity -PTPN6 SHP-1 EC 3.1.3.48; Motility/polarity/chemotaxis; PHOSPHATASE; Protein phosphatase, tyrosine (non-receptor) P29350 5777 12p13.31 human S556-p 15406102 HAKASRTsSKHKEDV enzymatic activity, induced cell adhesion, induced; signaling pathway regulation 21177494 1 2 5 Src activation via SHP-1 and SHP-2, and then ERK activation -Sirt2 SIRT2 iso2 DEACETYLASE; Deacetylase; EC 3.5.1.- Q8VDQ8-2 64383 7|7 B1 mouse S332-p 482809 PNPSTTIsPGKSPPP signaling pathway regulation 24013120 7 31 0 suppresses cell death and in?ammation and neurotoxicity in microglia -DHCR24 Diminuto EC 1.3.1.72; Lipid Metabolism - steroid biosynthesis; Membrane protein, integral; Oxidoreductase Q15392 1718 1p32.3 human Y299-p 473187 KLNSIGNyYKPWFFK protein stabilization; enzymatic activity, induced 24363437 1 0 1 -FANCI FANCI Cell cycle regulation; DNA repair, damage Q9NVI1 55215 15q26.1 human S565-p 114809700 CSQSLSVsQVHVDVH FANCI_HD2 molecular association, regulation; ubiquitination DNA(INDUCES) 28636932; 32117957 2 1 0 prevents deubiquitination of FANCD2 -SH3GLB1 endophilin B1 Apoptosis; Autophagy; EC 2.3.1.-; Mitochondrial; Transferase Q9Y371 51100 1p22.3 human Y80-p 465105 ARIEEFVyEKLDRKA BAR molecular association, regulation apoptosis, inhibited BAX(DISRUPTS) 18474606 1 9 267 -MAPT Tau iso8 ACETYLTRANSFERASE; Acetyltransferase; Cytoskeletal P10636-8 4137 17q21.31 human S258-p 487453 PDLKNVKsKIGSTEN Tubulin-binding molecular association, regulation 21204788 2 1 0 in vitro microtubule binding -COIL coilin Oxidoreductase P38432 8161 17q22 human S271-p 3190114 VTLEARNsSEKLPTE cell growth, inhibited 21991343 1 21 0 Cajal body formation, phosphomutant cell lines show a significant reduction in CB formation compared to wild-type after endogenous coilin knockdown -CALM1 Calmodulin Calcium-binding; Protein phosphatase, regulatory subunit P0DP23 801 14q32.11 human S102-p 448706 KDGNGYIsAAELRHV EF-hand_7 protein conformation 26675311 7 27 40 -PTTG1 Securin Cell cycle regulation; Oncoprotein O95997 9232 5q33.3 human K9-ub 486269 ATLIYVDkENGEPGT Securin protein degradation 11179223 1 1 0 required for sister chromatid separation -CD33 CD33 Cell adhesion; Membrane protein, integral P20138 945 19q13.41 human Y340-p 450952 EMDEELHyASLNFHG molecular association, regulation SHP-2(INDUCES); SHP-1(INDUCES) 10206955; 10887109 2 0 0 While tyrosine phosphorylation of CD33 was shown to induce its interaction in cells with SHP-1 and SHP-2, the specific contribution of Y340 phosphorylation to these interactions was based on in vitro binding experiments. -PPP5C PPP5C EC 3.1.3.16; PHOSPHATASE; Protein phosphatase, Ser/Thr (non-receptor) P53041 5536 19q13.32 human T362-p 344893200 LFSEDGVtLDDIRKI Metallophos enzymatic activity, induced cell growth, induced; apoptosis, inhibited 29141220 1 1 0 -Smad3 SMAD3 DNA-binding; Nuclear receptor co-regulator; Transcription factor Q8BUN5 17127 9|9 C mouse S425-p 448336 SIRCSSVs_______ molecular association, regulation; intracellular localization carcinogenesis, induced; cell growth, induced; cell motility, induced; cell growth, inhibited; cell differentiation, induced; transcription, induced SMAD4(INDUCES) DNA(INDUCES) 30042129; 32122971; 34799661; 37350664 41 0 5 -Nfkbia IkB-alpha DNA-binding; Inhibitor Q9Z1E3 18035 12|12 C1 mouse S36-p 448204 RHDSGLDsMKDEEYE protein degradation 10497169; 22633953 99 2 6 -NPHP1 NPHP1 Cell adhesion O15259 4867 2q13 human Y349-p 18449510 GNQFRANyFLQPELM molecular association, regulation; intracellular localization PACS-1(INDUCES) 21357692 1 0 0 -Axin1 axin 1 Adaptor/scaffold; Tumor suppressor O70239 79257 10q12 rat S321-p 2226507 PATSANDsEQQSLSS cytoskeletal reorganization 22933777 1 0 0 Phosphorylation regulates responsive to Sema3A induced growth cone collapse. -FYB1 SLAP-130 Adaptor/scaffold O15117 2533 5p13.1 human Y559-p 15149800 GRTARGSyGYIKTTA SH3_2 cell motility, altered; cell adhesion, altered 20661443 3 2 13 promotes adhesion to fibronectin; promotes cell migration -TNNI3 TNNI3 Actin-binding; Motility/polarity/chemotaxis; Motor P19429 7137 19q13.42 human S39-p 3146608 EPHAKKKsKISASRK molecular association, regulation TNNC1(DISRUPTS) 11121119 1 0 0 -NUPR1 NUPR1 Apoptosis; Cell cycle regulation; Cell development/differentiation O60356 26471 16p11.2 human K65-ac 465461 SPGGHERkLVTKLQN Phospho_p8 intracellular localization 16294328 1 0 0 regulates nuclear transport -KCNB1 Kv2.1 Channel, cation; Channel, ligand-gated; Channel, potassium; Membrane protein, integral; Membrane protein, multi-pass Q14721 3745 20q13.13 human S800-p 473567 EKNHFESsPLPTSPK activity, induced; intracellular localization; phosphorylation apoptosis, induced 19622611; 23857585; 26115091 5 3 0 induces phosphorylation at Y128 and membrane insertion of the channel; increased channel activity -MAPK11 P38B EC 2.7.11.24; KINASE; Kinase, protein; Protein kinase, CMGC; Protein kinase, Ser/Thr (non-receptor) Q15759 5600 22q13.33 human T180-p 15405068 RQADEEMtGYVATRW Pkinase enzymatic activity, induced 26976637 2 2 57 -NHERF1 NHERF Adaptor/scaffold; Motility/polarity/chemotaxis O14745 9368 17q25.1 human S162-p 450312 CTMKKGPsGYGFNLH PDZ molecular association, regulation CFTR(DISRUPTS) 12881487 3 9 1 -ABL1 Abl EC 2.7.10.2; KINASE; Kinase, protein; Oncoprotein; Protein kinase, TK; Protein kinase, tyrosine (non-receptor) P00519 25 9q34.12 human S446-p 450296 PYPGIDLsQVYELLE PK_Tyr_Ser-Thr enzymatic activity, induced 9168116 2 0 0 -Stxbp3 STXBP3 Vesicle Q60770 20912 3|3 F3 mouse Y218-p 463817 VEKKLEDyYKIDEKG Sec1 molecular association, regulation STX4(DISRUPTS) 23937695 2 0 0 2-deoxy-glucose uptake in adipocytes -RPS6KA1 p90RSK EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, AGC; Protein kinase, Ser/Thr (non-receptor); Translation Q15418 6195 1p36.11 human K421-sm 1881518210 FSDGYVVkETIGVGS molecular association, regulation; phosphorylation EIF4B(INDUCES) 34871326 1 0 0 SUMO-SIM interaction contributes to RSK1-eIF4B association; sites incudinge IF4B (Ser 422 and Ser 425, 29.91 fold), SETD1A (Ser 915 and Ser 916, 25.76 fold), LMNA (Ser 404 and Ser 406, 16.42 fold), ZNF 217 (Ser 975, 13.27 fold); SUMOylation is required for is required for replication and virus production of KSHV; affect eIF4B phosphorylation by RSK1 in vitro; SUMOylation affects the phosphorylation levels of its substrates -PRKAA2 AMPKA2 Autophagy; EC 2.7.11.1; EC 2.7.11.27; EC 2.7.11.31; KINASE; Kinase, protein; Protein kinase, CAMK; Protein kinase, Ser/Thr (non-receptor) P54646 5563 1p32.2 human K470-ub 15489433 RSYLLDFkSIDDEVV AdenylateSensor enzymatic activity, inhibited 31996460 1 1 1 -NR4A2 NR4A2 DNA-binding; Nuclear receptor P43354 4929 2q24.1 human T132-p 487426 SSPPTPTtPGFQVQH transcription, induced 17681692 2 0 0 -DNMT1 DNMT1 Amino Acid Metabolism - cysteine and methionine; Cell development/differentiation; EC 2.1.1.37; METHYLTRANSFERASE; Methyltransferase; Methyltransferase, DNA; Transcription regulation P26358 1786 19p13.2 human K957-ac 25171005 IKLSSPVkRPRKEPV BAH cell cycle regulation 21947282 1 1 0 -Myod1 MyoD DNA-binding; RNA splicing; Transcription factor P10085 17927 7 B3|7 30.03 cM mouse K99-ac 458968 RCLLWACkACKRKTT Basic activity, induced transcription, induced 10944526 3 1 0 -PGAM1 PGAM1 Carbohydrate Metabolism - glycolysis and gluconeogenesis; EC 3.1.3.13; EC 5.4.2.11; EC 5.4.2.4; Isomerase; Phosphatase (non-protein) P18669 5223 10q24.1 human S23-p 455496 WNLENRFsGWYDADL His_Phos_1 enzymatic activity, inhibited 12189148 1 17 14 -Bckdha BCKDH E1-alpha Amino Acid Metabolism - valine, leucine and isoleucine degradation; EC 1.2.4.4; Lyase; Mitochondrial; Oxidoreductase P11960 25244 1q21 rat S343-p 451657 DDSSAYRsVDEVNYW E1_dh enzymatic activity, inhibited 3947057 3 70 31 -Lats1 LATS1 EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, AGC; Protein kinase, Ser/Thr (non-receptor); Tumor suppressor F1M2K4 308265 1p13 rat T1079-p 457595 EHAFYEFtFRRFFDD phosphorylation 33568044 34 1 0 -FBXW7 FBXW7 Motility/polarity/chemotaxis; Nucleolus; UBIQUITIN LIGASE; Ubiquitin conjugating system; Ubiquitin ligase Q969H0 55294 4q31.3 human K412-ub 573780018 VWSAVTGkCLRTLVG WD40 protein degradation; molecular association, regulation TRIP12(INDUCES) 31186535; 33824312 2 2 0 -FLOT1 FLOT1 Adaptor/scaffold O75955 10211 6p21.33 human Y149-p 35494101 MGISVVSyTLKDIHD Band_7 molecular association, regulation SDHB(INDUCES) 24983503 1 0 0 decreased ROS productioned compared to Y56F and Y149F mutants -DAZAP1 DAZAP1 Motility/polarity/chemotaxis; RNA-binding Q96EP5 26528 19p13.3 human T315-p 467205 GVPPPPAtPGAAPLA molecular association, regulation DAZ1(DISRUPTS) 16848763 1 0 0 -CREB1 CREB DNA-binding; Transcription factor P16220 1385 2q33.3 human S119-p 448228 EILSRRPsYRKILND pKID activity, induced; molecular association, regulation; phosphorylation cell cycle regulation; carcinogenesis, induced; cell motility, induced; signaling pathway regulation; cell differentiation, altered; cell growth, induced; cell motility, altered; transcription, inhibited; cell differentiation, inhibited; carcinogenesis, inhibited; cell growth, inhibited; transcription, induced; transcription, altered; neural plasticity; DNA repair, induced; cell differentiation, induced; apoptosis, inhibited; translation, inhibited Myb(INDUCES); Nur77(INDUCES); CBP(INDUCES); MEIS1(INDUCES); p300(INDUCES); RGS13(INDUCES); TORC2(NOT_REPORTED); SOX9(INDUCES) DNA(INDUCES) 10558990; 12196545; 12660819; 14536081; 15033181; 15073328; 15073527; 15319449; 15454081; 15753290; 16301994; 16684769; 17389598; 17426037; 17429437; 18070920; 18775326; 19113914; 19651774; 20089855; 20541704; 20573984; 21422248; 23461423; 25404345; 27095572; 27191986; 29989005; 33846571; 34342229; 34411141; 34437633; 35378127; 35615594; 35901086; 36272644; 36459375; 36646789; 36773293; 7876182; 8552098; 8887554 311 5 61 -Mapkapk5 MAPKAPK5 EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, CAMK; Protein kinase, Ser/Thr (non-receptor); Tumor suppressor O54992 17165 5|5 F mouse T182-p 450093 VDQGDLMtPQFTPYY Pkinase acetylation; intracellular localization; phosphorylation; enzymatic activity, induced 12242275; 21336308; 23685072 6 10 94 increases acetylation MAPKAPK5-K364; induces phosphorylation of RHEB -IRF3 IRF3 DNA-binding; Transcription factor Q14653 3661 19q13.33 human T390-p 14665000 GASSLENtVDLHISN molecular association, regulation; phosphorylation CBP(INDUCES) 20511230 1 1 0 stimulates phosphorylation of S396 -PLCG1 PLCG1 Carbohydrate Metabolism - inositol phosphate; EC 3.1.4.11; Motility/polarity/chemotaxis; Phospholipase P19174 5335 20q12 human Y771-p 448575 IGTAEPDyGALYEGR activity, inhibited signaling pathway regulation 12652307 16 41 552 -NFE2 NF-E2 Cytoskeletal; DNA-binding; Transcription factor Q16621 4778 12q13.13 human K241-ub 11489906 KIPFPTDkIVNLPVD bZIP_Maf protein degradation; ubiquitination transcription, inhibited 19966288 1 0 1 -Sipa1l1 SIPA1L1 GAP; GAP, Ras O35412 246212 6q24 rat S1344-p 26348503 LQGTSADsGIDTASY protein degradation; molecular association, regulation; ubiquitination BTRC(INDUCES) 18723513 1 1 0 -PRKAA2 AMPKA2 Autophagy; EC 2.7.11.1; EC 2.7.11.27; EC 2.7.11.31; KINASE; Kinase, protein; Protein kinase, CAMK; Protein kinase, Ser/Thr (non-receptor) Q28948 397504 pig T172-p 448026 SDGEFLRtSCGSPNY Pkinase signaling pathway regulation 23799098 220 13 33 simvastatin-induced signaling for the closure of K-ATP channel -SEPTIN7 SEPT7 Cell cycle regulation; Cytoskeletal; Hydrolase Q16181 989 7p14.2 human T198-p 56658862 PLIAKADtLTPEECQ Septin molecular association, regulation cytoskeletal reorganization SEPT7(DISRUPTS) 33572403 1 2 0 inhibits ciliogenesis and septin filament formation -YBX1 YB-1 RNA processing; RNA splicing; RNA-binding; Transcription factor P67809 4904 1p34.2 human K81-ac 11322087 FINRNDTkEDVFVHQ CSD translation, inhibited 31668005 1 4 0 MS275 inhibits translation, and inhibits sarcoma metastasis in vivo, but mutant K81A rescues metastatic phenotype, blocks YB- 1-mediated pro-metastatic activity in sarcoma cells -PKP1 plakophilin 1 Cell adhesion; Motility/polarity/chemotaxis Q13835 5317 1q32.1 human S185-p 15405312 KTTQNRYsFYSTCSG activity, induced; protein stabilization cell motility, induced; cell growth, induced; translation, induced; cell adhesion, inhibited 23444369 1 4 76 -Tgs1 PIMT EC 2.1.1.-; METHYLTRANSFERASE; Methyltransferase; Nuclear receptor co-regulator; RNA processing P85107 312947 5q12 rat S295-p 3636737 DGTTLSSsPNTAEDE transcription, induced; transcription, inhibited 26468734 2 3 2 HDAC5 expression; inhibition of glucose uptake, attenuates GLUT4 and MEF2A expression -PTH1R PTHR GPCR, family 2; Membrane protein, integral; Membrane protein, multi-pass; Receptor, GPCR Q03431 5745 3p21.31 human T392-p 801662703 LATKLREtNAGRCDT 7tm_2 molecular association, regulation; ubiquitination ARRB1(INDUCES) 29444827 1 1 0 abrogation of phosphorylation at positions T387and T392 dramatically decreased PTHR ubiquitination -MORC3 MORC3 Cell cycle regulation; RNA-binding Q14149 23515 21q22.12 human K597-sm 14988616 VDHDIDMkSEQSHVE molecular association, regulation PML(INDUCES) 20501696 1 2 0 -DNMT1 DNMT1 Amino Acid Metabolism - cysteine and methionine; Cell development/differentiation; EC 2.1.1.37; METHYLTRANSFERASE; Methyltransferase; Methyltransferase, DNA; Transcription regulation P26358 1786 19p13.2 human K1111-ac 466385 RSPGNKGkGKGKGKG cell cycle regulation; transcription, inhibited 21947282 1 4 0 -Pdha1 PDHA1 Amino Acid Metabolism - valine, leucine and isoleucine biosynthesis; Carbohydrate Metabolism - butanoate; Carbohydrate Metabolism - citrate (TCA) cycle; Carbohydrate Metabolism - glycolysis and gluconeogenesis; Carbohydrate Metabolism - pyruvate; EC 1.2.4.1; Mitochondrial; Oxidoreductase P35486 18597 X F4|X 73.95 cM mouse K336-ac 11324468 LASVEELkEIDVEVR E1_dh enzymatic activity, inhibited; phosphorylation 23835326 1 4 2 -Nyap2 NYAP2 Cell development/differentiation Q8BM65 241134 1|1 C5 mouse Y300-p 455105 DDQSEAVyEEMKYPI NYAP_N molecular association, regulation PIK3R1(INDUCES) 21946561 1 5 21 localization to the neuronal plasma membrane, interaction with WAVE complex -ACOX1 ACOX1 EC 1.3.3.6; Lipid Metabolism - alpha-linolenic acid; Lipid Metabolism - fatty acid; Lipid Metabolism - unsaturated fatty acid biosynthesis; Oxidoreductase Q15067 51 17q25.1 human S26-p 3196823 LTHILDGsPEKTRRR Acyl-CoA_ox_N protein stabilization; ubiquitination; phosphorylation; palmitoylation carcinogenesis, inhibited; cell growth, inhibited; transcription, altered 36878899 1 21 0 induces CTNNB1 palmitoylation, regulates phosphorylation of downstream proteins and the DUSP14-ACOX1-PA-?-catenin signaling pathway -MDM2 MDM2 EC 6.3.2.-; EC 6.3.2.19; Inhibitor; Ligase; NEDDYLATION LIGASE; Neddylation Ligase; Nucleolus; Oncoprotein; UBIQUITIN LIGASE; Ubiquitin conjugating system; Ubiquitin ligase Q00987 4193 12q15 human S262-p 454944 DSEDYSLsEEGQELS activity, induced 12167711 3 1 0 promotes p53 degradation -Cttn Cortactin Actin-binding; Cytoskeletal; Motility/polarity/chemotaxis Q60598 13043 7|7 F5 mouse T401-p 449245 QARAKKQtPPASPSP cell cycle regulation; cell motility, altered 18515860 2 95 117 -Olig2 OLIG2 Oncoprotein; Transcription factor Q9EQW6 50913 16 C3.3|16 52.6 cM mouse K112-sm 1869334001 ELQQLRLkINSRERK HLH molecular association, regulation cell cycle regulation; carcinogenesis, induced; apoptosis, inhibited; DNA repair, inhibited; transcription, inhibited HDAC1(INDUCES) DNA(INDUCES) 32483381 1 1 0 -BAP1 BAP1 DEUBIQUITINASE; EC 3.4.19.12; Protease; Tumor suppressor; Ubiquitin conjugating system; Ubiquitin-specific protease Q92560 8314 3p21.1 human T273-p 31012813 TQPELIQtHKSQESQ intracellular localization DNA repair, induced 24347639 1 1 0 -SMAD3 SMAD3 DNA-binding; Nuclear receptor co-regulator; Transcription factor P84022 4088 15q22.33 human K378-ac 466353 TIRMSFVkGWGAEYR MH2 activity, induced transcription, induced 16862174; 32305562 3 4 0 -SOS1 SOS1 Adaptor/scaffold; GEF; GEF, Ras; Motility/polarity/chemotaxis Q07889 6654 2p22.1 human S1193-p 451316 QPTSKAYsPRYSISD molecular association, regulation GRB2(DISRUPTS) 8816480 1 1 0 -MAPRE1 EB1 Cytoskeletal; Motility/polarity/chemotaxis Q15691 22919 20q11.21 human K220-ac 11319860 ERDFYFGkLRNIELI EB1 molecular association, regulation; protein conformation cell cycle regulation; cytoskeletal reorganization MTUS2(DISRUPTS); KIF2C(DISRUPTS) 23001180 1 2 0 intramoleclar interaction, negatively regulates EB1 binding with SxIP motif of cargo proteins -CBLC Cbl-c EC 6.3.2.-; Ligase; NEDDYLATION LIGASE; Neddylation Ligase; UBIQUITIN LIGASE; Ubiquitin conjugating system; Ubiquitin ligase Q9ULV8 23624 19q13.32 human Y341-p 14913506 SEEQLQLyWAMDSTF protein degradation; molecular association, regulation; phosphorylation; enzymatic activity, induced UBE2D2(DISRUPTS) 20525694; 24425877 2 0 0 Y341 phosphorylation increases Ret ubquitylation; in vitro -Pax3 PAX3 DNA-binding; Oncoprotein; Transcription factor P24610 18505 1 C4|1 39.79 cM mouse S201-p 18744500 ERASAPQsDEGSDID cell growth, induced; transcription, inhibited 27588498 4 2 0 -MAF1 MAF1 Transcription regulation Q9H063 84232 8q24.3 human K35-sm 31094506 RIESYSCkMAGDDKH Maf1 molecular association, regulation cell growth, inhibited; transcription, inhibited POLR3A(INDUCES) 23673667 1 0 0 -MYH9 MYH9 Actin-binding; Motility/polarity/chemotaxis; Motor P35579 4627 22q12.3 human S1803-p 2482303 EMEGTVKsKYKASIT Myosin_tail_1 intracellular localization cytoskeletal reorganization 18394644 1 1 1 -NFE2L2 NRF2 DNA-binding; Transcription factor Q16236 4780 2q31.2 human S374-p 35497700 GDTLLGLsDSEVEEL activity, induced; protein degradation; protein stabilization; molecular association, regulation; ubiquitination transcription, induced; transcription, inhibited; signaling pathway regulation BTRC(INDUCES); FBW1B(INDUCES) 31805502; 37627580 2 2 0 -Mefv pyrin Actin-binding Q9JJ26 54483 16 A1|16 2.18 cM mouse S205-p 455897 AQLRRNVsSAGRLQG molecular association, regulation; activity, inhibited 14-3-3 epsilon(INDUCES) 27482109 8 1 2 dephosphorylation triggers 14-3-3 dissociation, activation, formation of an oligomeric Pyrin inflammasome complex -PGR PR DNA-binding; Nuclear receptor; Transcription factor P06401 5241 11q22.1 human K388-sm 486289 QPPALKIkEEEEGAE Prog_receptor sumoylation; protein stabilization; intracellular localization; protein conformation; activity, inhibited cell differentiation, inhibited; transcription, induced; transcription, inhibited; cell growth, altered 12114521; 12529333; 17020914; 17053081; 17717077; 19211567; 19706513; 22439847 11 0 0 represses basal proliferation of breast cancer cells; SENP1 and SENP2 strongly enhanced the transcription of WT liganded PR. -EGFR EGFR EC 2.7.10.1; KINASE; Kinase, protein; Membrane protein, integral; Oncoprotein; Protein kinase, TK; Protein kinase, tyrosine (receptor) P00533 1956 7p11.2 human K960-ub 1065310 IDADSRPkFRELIIE PK_Tyr_Ser-Thr protein degradation 17940017 1 1 0 -CREB1 CREB DNA-binding; Transcription factor P16220 1385 2q33.3 human S97-p 451808 TIAESEDsQESVDSV molecular association, regulation; activity, inhibited; phosphorylation transcription, inhibited CBP(INDUCES) 15073328; 17209043 9 3 3 -Tnnt2 TNNT2 iso2 Motility/polarity/chemotaxis; Motor P50753-2 24837 13q13 rat T195-p 449038 GYIQKAQtERKSGKR Troponin protein conformation 24708997 6 0 0 T204E mutant blunts Ca2+ sensitivity, PKC phosphorylation of these residues can increase or decrease Ca2+ sensitivity and cardiac regulation -BRCA1 BRCA1 EC 6.3.2.-; Nuclear receptor co-regulator; Transcription, coactivator/corepressor; Tumor suppressor; UBIQUITIN LIGASE; Ubiquitin conjugating system; Ubiquitin ligase P38398 672 17q21.31 human S1457-p 450008 SEKAVLTsQKSSEYP molecular association, regulation cell cycle regulation; DNA repair, altered ATM(INDUCES) 10550055; 26320175 7 4 1 prolong mitosis and induce mitotic aberrations -N Nucleocapsid Protein P59595 1489678 SARSCoV1 S202-p 1868174951 SRNSTPGsSRGNSPA CoV_nucleocap molecular association, regulation Nucleocapsid Protein(INDUCES) 23717688 2 3 0 di-domain self-association -AURKA AurA EC 2.7.11.1; KINASE; Kinase, protein; Oncoprotein; Protein kinase, Other; Protein kinase, Ser/Thr (non-receptor) O14965 6790 20q13.2 human K143-ub 21129736 GRPLGKGkFGNVYLA Pkinase protein degradation; enzymatic activity, inhibited carcinogenesis, inhibited; cell growth, inhibited 34758762 1 6 0 -GRK7 GRK7 EC 2.7.11.14; EC 2.7.11.16; KINASE; Kinase, protein; Protein kinase, AGC; Protein kinase, Ser/Thr (non-receptor) Q8WTQ7 131890 3q23 human S23-p 456354 YLQARKPsDCDSKEL enzymatic activity, inhibited 15946941 1 0 0 reaction in vitro -Ctnnd2 CTNND2 Actin-binding; Motility/polarity/chemotaxis O35927 18163 15|15 B2 mouse T1078-p 2020381 RPYSSSRtPSISPVR protein degradation; ubiquitination 19706605 1 4 0 -FXYD1 PLM Cell surface; Channel, misc.; Membrane protein, integral O00168 5348 19q13.12 human S88-p 451425 RSSIRRLsTRRR___ activity, induced; molecular association, regulation; protein conformation; enzymatic activity, induced ATP1A1(DISRUPTS); PLM(INDUCES) 21220422; 21653224; 24105627; 26429909; 33635930 27 3 74 induces NKA activity; reverse PLM bindiing inhibition of Na,K-ATPase activity -Acaca ACC1 Carbohydrate Metabolism - propanoate; Carbohydrate Metabolism - pyruvate; EC 6.3.4.14; EC 6.4.1.2; Ligase; Lipid Metabolism - fatty acid biosynthesis P11497 60581 10q26 rat S29-p 448771 GSVSEDNsEDEISNL enzymatic activity, inhibited 2900140 1 77 3 -Apbb1ip RIAM Adaptor/scaffold; Motility/polarity/chemotaxis Q8R5A3 54519 2|2 A3 mouse Y267-p 1871479100 FLEKEERyAVFKNPQ activity, induced; intracellular localization cell adhesion, induced; signaling pathway regulation 33275877 1 0 0 induces integrin activation/ integrin signaling pathway -Hdac7 HDAC7 DEACETYLASE; Deacetylase; EC 3.5.1.98; Hydrolase Q8C2B3 56233 15|15 F1 mouse S479-p 452459 RPLSRTQsSPAAPVS molecular association, regulation 14-3-3 epsilon(DISRUPTS) 16956611 7 31 66 -EPHA2 EphA2 EC 2.7.10.1; KINASE; Kinase, protein; Membrane protein, integral; Protein kinase, TK; Protein kinase, tyrosine (receptor) P29317 1969 1p36.13 human Y960-p 461994 GHQKRIAySLLGLKD SAM_1 molecular association, regulation SHIP-2(INDUCES) 24825902 2 12 57 -PA2G4 Ebp1 Nuclear receptor co-regulator; Nucleolus; Transcription, coactivator/corepressor Q9UQ80 5036 12q13.2 human S360-p 478276 ELKALLQsSASRKTQ protein stabilization; molecular association, regulation; intracellular localization apoptosis, inhibited; transcription, induced; cell growth, altered TIF1A(INDUCES); NPM1(INDUCES); Akt1(INDUCES) 16642037; 17316401; 17951246; 25691158 5 2 1 enhanced rRNA synthesis; in cells stimulated with EGF; sumoylation of NPM K263 and K230 is required for the association between NPM and PA2G4 and distribution of PA2G4 in cells; detected in mitotic cells, but not in interphase cells; phosphorylation of this site protects PA2G4 (aka Ebp1) from apoptotic degradation and promotes cell survival -GTF2I GTF2I iso2 DNA-binding; Transcription, coactivator/corepressor P78347-2 2969 7q11.23 human Y611-p 448253 KPELVISyLPPGMAS cell cycle regulation; transcription, induced; transcription, altered 11934902; 16314517 2 0 0 -TRPC3 TRPC3 Channel, cation; Membrane protein, integral; Membrane protein, multi-pass Q13507 7222 4q27 human T646-p 20612407 LQISLGRtVKDIFKF Ion_trans molecular association, regulation transcription, induced; signaling pathway regulation PPP3CA(INDUCES) 21653882 1 0 0 phosphorylation of TPRC3 converts it into a transcriptionally active mode and dephosphorylation converts it into trancriptionally silent mode. -Slc1a2 GLT1 Membrane protein, integral; Membrane protein, multi-pass; Transporter; Transporter, SLC family P31596 29482 3q32 rat K550-ub 4667700 SVVIDECkVTLAANG receptor internalization, induced; protein degradation 18805448 2 0 0 -CTNNB1 CTNNB1 Actin-binding; Cell adhesion; Motility/polarity/chemotaxis; Nuclear receptor co-regulator; Oncoprotein; Transcription factor P35222 1499 3p22.1 human K19-ac 5013900 MAMEPDRkAAVSHWQ protein stabilization; intracellular localization carcinogenesis, inhibited; cell motility, induced; transcription, induced 18987336 3 0 0 -Grin2b NMDAR2B Channel, calcium; Channel, ligand-gated; Membrane protein, integral; Membrane protein, multi-pass Q01097 14812 6 G1|6 66.38 cM mouse S1116-p 3984496 YRRRPPRsPDHKRYF NMDAR2_C receptor internalization, induced CDK5(INDUCES) 24607229 1 2 2 disruption of interaction facilitates synaptic transmission and ehancement of fear memory -PCNA PCNA Cell cycle regulation; DNA replication P12004 5111 20p12.3 human Y133-p 231166700 LGIPEQEySCVVKMP PCNA_C ubiquitination cell cycle regulation 28924044 1 1 0 -ABL1 Abl iso2 EC 2.7.10.2; KINASE; Kinase, protein; Oncoprotein; Protein kinase, TK; Protein kinase, tyrosine (non-receptor) P00519-2 25 9q34.12 human T197-p 12121095 VYHYRINtASDGKLY SH2 enzymatic activity, inhibited apoptosis, inhibited 23852372 1 0 0 -NFKB1 NFkB-p105 DNA-binding; Transcription factor P19838 4790 4q24 human S20-p 18751700 QMFHLDPsLTHTIFN molecular association, regulation DNA(INDUCES) 20966071 1 0 0 -MAPT Tau iso8 ACETYLTRANSFERASE; Acetyltransferase; Cytoskeletal P10636-8 4137 17q21.31 human T217-p 449078 SRTPSLPtPPTREPK O-GlcNAc glycosylation; molecular association, regulation; intracellular localization cytoskeletal reorganization Tau iso8(INDUCES) 15190058; 16987243; 19451179; 20550628 41 34 6 hyperphosphorylation of this site decreases O-GlcNAcylation of tau ; polymerized into filaments when 4?6 mol of phosphate per mol of tau were incorporated; decreases rate of microtubule assembly; Phosphotylated sites found in the somato-dendritic campartment but not in the axon, where tau was not phosphorylated (T205 and T217), or not simultaneously phosphorylated (T231 and 235). -Pard3 PAR3-alpha Adaptor/scaffold; Motility/polarity/chemotaxis Q9Z340 81918 19q12 rat S889-p 455653 LGLKKSSsLESLQTA molecular association, regulation; intracellular localization cytoskeletal reorganization 14-3-3 zeta(INDUCES) 33093242 4 1 0 regulation of PAR3 oligomerization, regulation of tight junction formations and morphological changes in epithelial cell layer -Znf622 ZNF622 Transcription factor Q91VY9 52521 15 B1|15 9.71 cM mouse T251-p 63052801 PLGAIPItDCLFCSH zf-C2H2_2 protein stabilization; molecular association, regulation; enzymatic activity, induced apoptosis, induced; transcription, induced; signaling pathway regulation 28195154 1 0 0 -SMARCAL1 SMARCAL1 EC 3.6.1.-; EC 3.6.4.-; Helicase Q9NZC9 50485 2q35 human S129-p 29606710 ISPPLAQsPPEVPKQ protein degradation 30996091 1 12 0 -AR AR DNA-binding; Nuclear receptor; Transcription factor P10275 367 Xq12 human S579-p 4275600 YGALTCGsCKVFFKR zf-C4 activity, induced; protein degradation; molecular association, regulation; ubiquitination; intracellular localization carcinogenesis, inhibited; transcription, induced Ku70(DISRUPTS); Ku80(DISRUPTS); MDM2(INDUCES) 18511414; 23132866; 27902483 3 0 0 nuclear translocation inhibited -PIGL PIGL DEACETYLASE; Deacetylase; EC 3.5.1.89; Glycan Metabolism - glycosylphosphatidylinositol (GPI)-anchor biosynthesis; Membrane protein, integral Q9Y2B2 9487 17p11.2 human Y81-p 1881980200 LCFSAGNyYNQGETR molecular association, regulation; intracellular localization carcinogenesis, induced KPNB1(DISRUPTS); Myc(DISRUPTS); KPNA2(DISRUPTS) 37280393 1 0 0 -Htt Huntingtin Cytoskeletal P42859 15194 5 B2|5 17.92 cM mouse S1179-p 465620 EQASTPMsPKKVGEA intracellular localization cell differentiation, inhibited; exocytosis, inhibited; cell growth, inhibited; apoptosis, inhibited; transcription, inhibited 17611284; 23678106; 32640230 4 29 2 -EZH2 EZH2 EC 2.1.1.43; METHYLTRANSFERASE; Methyltransferase; Methyltransferase, protein lysine Q15910 2146 7q36.1 human S21-p 457606 CWRKRVKsEYMRLRQ molecular association, regulation; intracellular localization; enzymatic activity, inhibited; enzymatic activity, induced carcinogenesis, induced; DNA repair, induced; cell growth, induced; apoptosis, inhibited; transcription, induced H3(DISRUPTS); NFAT2(INDUCES) 16224021; 26517694; 34230470; 34943970; 35031563 9 1 1 -Map3k8 Cot EC 2.7.11.25; KINASE; Kinase, protein; Oncoprotein; Protein kinase, STE; Protein kinase, Ser/Thr (non-receptor) Q07174 26410 18 A1|18 2.73 cM mouse T290-p 455276 LPKDLRGtEIYMSPE Pkinase intracellular localization; phosphorylation; enzymatic activity, induced transcription, induced; signaling pathway regulation 15778223; 33488582 6 0 0 ; induces phosphorylation of IRF3, thus inducing IRF3/IFN-beta signaling -LAT LAT Adaptor/scaffold; Membrane protein, integral O43561 27040 16p11.2 human Y200-p 448004 SMESIDDyVNVPESG LAT activity, induced; molecular association, regulation cytoskeletal reorganization; transcription, induced; transcription, altered SLP76(INDUCES); GRB2(INDUCES); PLCG1(INDUCES); GADS(INDUCES) 10811803; 11046020; 20460647; 33929486 24 1 17 NF-AT mediated transcription; Does not regulate integrin mediated adhesion.; association of LAT-rich vesicles with surface clusters of SLP76 -BCL2 Bcl-2 Apoptosis; Autophagy; Membrane protein, integral; Oncoprotein P10415 596 18q21.33 human S70-p 448395 RDPVARTsPLQTPAA molecular association, regulation; intracellular localization; activity, inhibited cell cycle regulation; carcinogenesis, induced; apoptosis, altered; autophagy, induced; apoptosis, induced; apoptosis, inhibited; cell growth, altered BAX(INDUCES); beclin 1(DISRUPTS); BAX(DISRUPTS); p53(DISRUPTS) 10567572; 11077443; 12101183; 12421819; 15210690; 15703383; 16738310; 17097560; 17377139; 18570871; 18794113; 19029119; 21726807; 21778226; 28237688; 31959066; 34280220; 35013120; 36455198 49 1 0 -Gata1 GATA1 DNA-binding; Transcription factor P17679 14460 X A1.1|X 3.59 cM mouse K308-ac 459195 GIQTRNRkASGKGKK protein degradation; acetylation; ubiquitination; phosphorylation DNA(INDUCES) 16858405 2 1 0 Phosphorylation and acetylation cause the degradation of acetylated GATA-1; acetylation of GATA-1 causes ubiquitination; DNA binding is required for MAPK-dependent phosphorylation -FOXO1 FOXO1A DNA-binding; Nuclear receptor co-regulator; Oncoprotein; Transcription factor Q12778 2308 13q14.11 human S234-p 4258804 QNEGTGKsSWWMLNP Forkhead molecular association, regulation DNA(DISRUPTS) 18786403 1 1 0 -NCOA3 SRC-3 ACETYLTRANSFERASE; Acetyltransferase; EC 2.3.1.48; Motility/polarity/chemotaxis; Nuclear receptor co-regulator; Transcription, coactivator/corepressor Q9Y6Q9 8202 20q13.12 human S867-p 454107 SPVSVGSsPPVKNIS molecular association, regulation carcinogenesis, induced; cell growth, induced; transcription, induced ER-alpha(DISRUPTS) 15383283; 16760465; 33542078 5 12 0 -RUNX3 AML2 DNA-binding; Transcription factor Q13761 864 1p36.11 human K94-ub 11998600 KTLPVAFkVVALGDV Runt protein degradation; intracellular localization transcription, inhibited 19808967 1 0 0 nuclear export -Ahcyl1 AHCYL1 Amino Acid Metabolism - cysteine and methionine; EC 3.3.1.1; Hydrolase; Other Amino Acids Metabolism - selenoamino acid Q80SW1 229709 3 F2.3|3 46.83 cM mouse S80-p 25729419 DSYSSAAsYTDSSDD molecular association, regulation PIP5K1A(INDUCES) 26509711 1 0 3 -Rps6ka5 MSK1 EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, AGC; Protein kinase, Ser/Thr (non-receptor) Q8C050 73086 12|12 E mouse T764-p 471413 LSSNPLMtPDILGSS phosphorylation; enzymatic activity, induced 17117922 1 4 16 T645 phosphorylation -TELO2 TELO2 Adaptor/scaffold Q9Y4R8 9894 16p13.3 human S491-p 15668106 GSDSDLDsDDEFVPY molecular association, regulation; intracellular localization; enzymatic activity, induced DNAPK(INDUCES); ATM(INDUCES); PIH1D1(INDUCES) 20864032; 24656813; 24657168 3 2 0 increase stablization of DNA-PKs, ATM and PIKKs; this interaction (as a part of R2TP/prefoldin-like complex) is important for mTor and Smg1 stability; Phosphopeptide binding activity of PIH1D1 is important for the function of R2TP complex. -SF3B1 SF3B1 RNA splicing; RNA-binding; Spliceosome O75533 23451 2q33.1 human T244-p 455541 GRAKGSEtPGATPGS molecular association, regulation NIPP-1(INDUCES) 12105215 1 36 6 -Atr ATR EC 2.7.11.1; KINASE; Kinase, protein; Membrane protein, integral; Protein kinase, Ser/Thr (non-receptor); Protein kinase, atypical Q9JKK8 245000 9|9 E3.3 mouse S431-p 456320 SGNNDEVsPKRRKLS enzymatic activity, induced 18606816 25 13 1 -MPV17 MPV17 Membrane protein, integral; Membrane protein, multi-pass; Mitochondrial P39210 4358 2p23.3 human T80-p 40586901 LDRFIPGtTKVDALK protein conformation 25861990 1 0 0 may influence channel voltage-dependant gating under oxidizing/reducing conditions -Dab1 DAB1 iso2 Adaptor/scaffold P97318-2 13131 4 C6|4 47.79 cM mouse S550-p 479424 EPSGDNIsPQDGS__ phosphorylation 16529723 1 0 0 inhibits tyrosine phosphorylation -Itgb2 ITGB2 Cell adhesion; Cell surface; Membrane protein, integral; Motility/polarity/chemotaxis; Receptor, misc. P11835 16414 10 C1|10 39.72 cM mouse T760-p 448533 NPLFKSAtTTVMNPK Integrin_b_cyt cell motility, induced; cell adhesion, induced 23823319 8 2 3 T-cell homing to lymphocytes -STAT1 STAT1 DNA-binding; Transcription factor P42224 6772 2q32.2 human K410-ac 459198 EFRHLQLkEQKNAGT STAT_bind molecular association, regulation; intracellular localization; phosphorylation cell growth, inhibited; apoptosis, induced; transcription, induced; signaling pathway regulation; transcription, inhibited PPAR-gamma(INDUCES); NFkB-p65(INDUCES) DNA(INDUCES); DNA(DISRUPTS) 16481475; 19171783; 21576370; 26504087 4 1 1 induces dephosphorylation STAT1, regulates STAT1-associated cytokine signaling; CD36 expression; association with NFkB inhibits NFkB-DNA binding ; inhibition of transcription and nuclear import is a result of its disruption of DNA binding, and nuclear import signal. and not acetylation -PLD2 PLD2 EC 3.1.4.4; Lipid Metabolism - ether lipid; Lipid Metabolism - glycerophospholipid; Motility/polarity/chemotaxis; Phospholipase O14939 5338 17p13.2 human S134-p 456492 ARFAVAYsPARDAGN PX enzymatic activity, induced 18625302 2 6 0 stimulates EGF-dependent insulin secretion in pancreatic beta-cells -JUN Jun Oncoprotein; Transcription factor P05412 3725 1p32.1 human K271-ac 458867 IAASKCRkRKLERIA bZIP_1 molecular association, regulation carcinogenesis, induced; transcription, induced; signaling pathway regulation; transcription, inhibited DNA(INDUCES) 11689449; 16214953; 27956703; 36010303 5 0 0 increases the transcriptional activity of targeted genes, acetylated high expression significantly increased MMP-9 mRNA levels; AP-1 signaling pathway -ILK ILK EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, Ser/Thr (non-receptor); Protein kinase, TKL Q13418 3611 11p15.4 human S343-p 448495 SMADVKFsFQCPGRM PK_Tyr_Ser-Thr molecular association, regulation Akt1(INDUCES) 11313365 4 0 1 -TFAP2C AP-2 gamma DNA-binding; Motility/polarity/chemotaxis; Transcription factor Q92754 7022 20q13.31 human K10-sm 2407420 WKITDNVkYEEDCED transcription, inhibited 12072434 1 0 0 -NEK3 NEK3 EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, Other; Protein kinase, Ser/Thr (non-receptor) P51956 4752 13q14.3 human T165-p 57829902 FACTYVGtPYYVPPE Pkinase enzymatic activity, induced cell motility, induced; cell adhesion, altered 27489110 1 0 0 focal adhesion maturation -ATP2A2 SERCA2 Cell adhesion; EC 3.6.3.8; Endoplasmic reticulum; Hydrolase; Membrane protein, integral; Membrane protein, multi-pass; Transporter; Transporter, ion channel P16615 488 12q24.11 human K541-ub 486899 VPMTSGVkQKIMSVI protein degradation 35611810 1 3 2 SIGMAR1 interacts with Q615 site and mediates SERCA2 degradation -NOVA2 NOVA2 Q9UNW9 4858 19q13.32 human S194-p 1869341903 EQVHKAVsAIVQKVQ KH_1 intracellular localization 32492405 1 1 0 Phosphorylated NOVA2 translocates to cytosol leading to reduced E29 inclusion in BK channel and thereby inhibiting BK channel activity. -MAPKAPK2 MAPKAPK2 EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, CAMK; Protein kinase, Ser/Thr (non-receptor) P49137 9261 1q32.1 human T222-p 448269 TSHNSLTtPCYTPYY Pkinase activity, induced; phosphorylation 23740979; 8846784 14 3 42 -FAAP20 FAAP20 iso2 Q6NZ36 199990 1p36.33 human K152-ub 41486807 RSCPMCQkEFAPRLT UBZ_FAAP20 protein degradation; ubiquitination FBXW7(INDUCES) 27232758 1 2 0 -YAP1 YAP1 iso2 Oncoprotein; Transcription, coactivator/corepressor P46937-2 10413 11q22.1 human S387-p 3190675 ESTDSGLsMSSYSVP ubiquitination BTRC(INDUCES) 20048001 2 3 0 -Carm1 CARM1 EC 2.1.1.125; METHYLTRANSFERASE; Methyltransferase; Methyltransferase, protein arginine; Nuclear receptor co-regulator Q9WVG6 59035 9|9 A3 mouse K228-ub 22241798 QHAEVLVkSNNLTDR PrmA protein degradation 34480022 1 3 0 Targeting CARM1 attenuates severity of cellular injury in an experimental mouse lung in?ammation model. -Ppp2ca PPP2CA EC 3.1.3.16; Motility/polarity/chemotaxis; PHOSPHATASE; Protein phosphatase, Ser/Thr (non-receptor) P63330 19052 11|11 B1.3 mouse Y307-p 448571 VTRRTPDyFL_____ enzymatic activity, inhibited; activity, inhibited; phosphorylation; enzymatic activity, induced cytoskeletal reorganization; cell motility, inhibited 18208556; 22729898; 23579329; 23590304; 23630944; 25002528; 25394676; 27183589; 35331293 73 1 0 astrocyte migration (motility) inhibited; induces eNOS dephosphorylation; AB accumulation ; activation of P38 MAPK abolishes astrocyte migration; PP2A activity inhibited -DDX3X DDX3 Cell cycle regulation; EC 3.6.4.13; Helicase; RNA-binding; Spliceosome; Translation initiation O00571 1654 Xp11.4 human K55-ub 22243166 ATKGFYDkDSSGWSS transcription, induced 34445801 1 6 0 RIG-I-mediated IFNB1 gene induction; in?uenza A virus non-structural protein 1 (NS1) disrupts the TRIM25-DDX3X interaction -PELP1 PELP1 Nuclear receptor co-regulator; Transcription, coactivator/corepressor Q8IZL8 27043 17p13.2 human S991-p 15334104 PALPPPEsPPKVQPE cell cycle regulation; carcinogenesis, altered; transcription, altered 20807815 1 1 0 -CHEK2 Chk2 EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, CAMK; Protein kinase, Ser/Thr (non-receptor); Tumor suppressor O96017 11200 22q12.1 human S140-p 6339800 TDKYRTYsKKHFRIF FHA protein conformation; enzymatic activity, induced PLK1(INDUCES) 18948271 1 0 0 dimerization and activation of of Chk2 -EEF2K EEF2K EC 2.7.11.20; KINASE; Kinase, protein; Protein kinase, Ser/Thr (non-receptor); Protein kinase, atypical; Translation O00418 29904 16p12.2 human T348-p 3150902 KLLQSAKtILRGTEE protein degradation; protein conformation; phosphorylation; enzymatic activity, induced 22216903; 24732796; 25012662; 25670349; 27956550; 29800565; 33890716 10 20 6 -PRC1 PRC1 Cell cycle regulation; Cytoskeletal; Microtubule-binding; Motility/polarity/chemotaxis O43663 9055 15q26.1 human Y464-p 474466 QTETEMLyGSAPRTP MAP65_ASE1 intracellular localization 33510346 1 8 47 -PDE8A PDE8A EC 3.1.4.53; Nucleotide Metabolism - purine; Phosphodiesterase O60658 5151 15q25.3 human S359-p 18261095 HKDRRKGsLDVKAVA enzymatic activity, induced 22673573 1 4 0 -TICRR TICRR Cell cycle regulation; DNA replication Q7Z2Z1 90381 15q26.1 human S1001-p 4752817 DIGVVEEsPEKGDEI Treslin_N molecular association, regulation; phosphorylation cell cycle regulation; signaling pathway regulation TOPBP1(INDUCES) 21646402; 21700459; 23696651; 25454945; 25737283; 35231445 6 16 0 It stimulates CHK1 phosphorylation by ATR in vitro and in vivo. It is involved in ATR-mediated checkpoint signaling.; DNA replication induced; shortens S phase, increases replication initiation -ZEB1 TCF8 C2H2-type zinc finger protein; DNA-binding; Motility/polarity/chemotaxis; Transcription, coactivator/corepressor P37275 6935 10p11.22 human K1108-ub 964549554 QASSLGQkVGESSEQ protein degradation 35342335 1 1 0 -SLX4 SLX4 DNA repair, damage; Deoxyribonuclease Q8IY92 84464 16p13.3 human T1571-p 1880104210 PQYSIMEtPVLKKEL molecular association, regulation; protein conformation MUS81(INDUCES) 36288699 1 1 0 -CDC25A CDC25A EC 3.1.3.48; Motility/polarity/chemotaxis; PHOSPHATASE; Protein phosphatase, dual-specificity P30304 993 3p21.31 human S320-p 1874397804 HQSLSLAsSPKGTIE M-inducer_phosp protein degradation; ubiquitination cell cycle regulation; apoptosis, inhibited 34363019 1 1 0 -RPL11 RPL11 Motility/polarity/chemotaxis; Nucleolus; Ribosomal; Translation P62913 6135 1p36.11 human K78-ne 12067610 HCTVRGAkAEEILEK Ribosomal_L5_C protein stabilization; intracellular localization 19713960 1 0 0 -MIP AQP0 Channel, misc.; Membrane protein, integral; Membrane protein, multi-pass; Transporter, aquaporin family P30301 4284 12q13.3 human S231-p 453399 FPRLKSIsERLSVLK molecular association, regulation Calmodulin(DISRUPTS) 18081321 2 2 0 -CAPZB CAPZB iso1 Actin-binding; Motility/polarity/chemotaxis P47756-1 832 1p36.13 human T186-p 14571038 TNKSGSGtMNLGGSL F_actin_cap_B cell motility, induced; cell adhesion, induced; cytoskeletal reorganization 32771000 1 3 1 -MRE11 MRE11A Cell cycle regulation; DNA repair, damage; DNA-binding; Deoxyribonuclease P49959 4361 11q21 human K339-ub 964527898 IQSFCLEkIEEMLEN Mre11_DNA_bind activity, induced; ubiquitination DNA repair, induced 36563124 1 2 0 MRE11A promotes its exonuclease activity -H4C1 H4 DNA-binding P62805 8359 6p22.2 human K91-ac 480248 MDVVYALkRQGRTLY CENP-T_C DNA repair, induced; transcription, induced 18985155; 23653357 4 5 253 -RIPK1 RIPK1 EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, Ser/Thr (non-receptor); Protein kinase, TKL Q13546 8737 6p25.2 human K377-ub 486338 NEPSLQSkLQDEANY protein degradation; molecular association, regulation; protein processing; enzymatic activity, inhibited; phosphorylation; enzymatic activity, induced carcinogenesis, induced; cell growth, induced; apoptosis, inhibited; transcription, induced; transcription, inhibited; signaling pathway regulation IKKB(INDUCES); TAK1(INDUCES); TAB2(INDUCES); FADD(INDUCES); IKKG(INDUCES) 16543241; 16603398; 21419663; 21613257; 23770847; 27270888 11 0 0 induces IKK-enzymatic activity and NF-kB-target gene transcription; promotes recruitment of RIPK downstream signaling components to the TNFR1 complex in lipid rafts leading to NFkB activation, In RIPK- cells apoptosis is induced. ; inhibits TLR3-induced NF-kB signaling ; promotes API2-MALT1-dependent lymphomagenesis via TNFR and antigen receptor-associated NF-kB signaling; induces RIPK1 cleavage by caspase-8; regulates antiapoptotic function of FAIM3 -Actn4 ACTN4 Cytoskeletal; Motility/polarity/chemotaxis P57780 60595 7|7 B1 mouse Y4-p 11498501 ____MVDyHAANQAY cytoskeletal reorganization 33532643 5 0 0 decreased binding to actin filaments has been observed after phosphorylation of this site -PYHIN1 PYHIN1 Tumor suppressor Q6K0P9 149628 1q23.1 human K110-ac 1881258604 PSKKTKQkEVYPATP intracellular localization 34156286 1 1 0 induces partial cytoplasmic localization -Atf3 ATF-3 Transcription factor Q60765 11910 1 H6|1 96.28 cM mouse K42-sm 31094511 ANLTPFVkEELRFAI protein stabilization; ubiquitination transcription, induced 26850942 3 1 0 inhibits ubiquitination -SMARCD3 SMARCD3 Nuclear receptor co-regulator; Transcription, coactivator/corepressor Q6STE5 6604 7q36.1 human S247-p 27422800 VKRPGDLsVRCTLLL molecular association, regulation; intracellular localization chromatin organization, altered; transcription, induced USF1(INDUCES) 23219531 1 1 0 -ELF4 ELF4 DNA-binding; Oncoprotein; Transcription factor Q99607 2000 Xq26.1 human S641-p 463812 SGSLLTRsPTPAPFS protein degradation transcription, induced; signaling pathway regulation 16581786; 21465527; 25081543 3 7 1 regulates MKK4/JNK pathway -Nr4a2 NR4A2 DNA-binding; Nuclear receptor Q06219 18227 2 C1.1|2 31.66 cM mouse T129-p 487425 YKPSSPPtPSTPSFQ intracellular localization 25752609 2 0 0 cytoplasmic translocation, required for H2O2-induced necrosis -YY1 YY1 C2H2-type zinc finger protein; Cell development/differentiation; Transcription factor P25490 7528 14q32.2 human S180-p 27276103 KKGGGKKsGKKSYLS molecular association, regulation DNA(INDUCES) 23226345 1 0 0 -CCND1 CCND1 Activator; Cell cycle regulation; Nuclear receptor co-regulator; Oncoprotein P24385 595 11q13.3 human T288-p 451435 VDLACTPtDVRDVDI protein degradation; intracellular localization 10766840; 17046823 5 0 0 -KEAP1 KEAP1 Endoplasmic reticulum; Motility/polarity/chemotaxis; Transcription regulation; UBIQUITIN LIGASE; Ubiquitin conjugating system Q14145 9817 19p13.2 human T277-p 15404187 AVRCHSLtPNFLQMQ BACK molecular association, regulation PIN1(INDUCES) 34918396 1 0 2 -ERBB4 HER4 EC 2.7.10.1; KINASE; Kinase, protein; Membrane protein, integral; Protein kinase, TK; Protein kinase, tyrosine (receptor) Q15303 2066 2q34 human K714-sm 1873286906 QAQLRILkETELKRV molecular association, regulation; intracellular localization; phosphorylation cell differentiation, induced; signaling pathway regulation Exportin-1(INDUCES) 28974580 1 0 0 nuclear accumulation regulated by Exportin-1-dependent nuclear export, increases autophosphorylation, required for the RIP-mediated nuclear signaling of ErbB4 ICD in mammary epithelial cells -PLCL1 PLCL1 Phospholipase Q15111 5334 2q33.1 human T246-p 467202 PRFMWLKtVFEAADV molecular association, regulation PPP1CA(INDUCES) 16854455 1 0 0 -Srsf1 SF2 RNA splicing; RNA-binding; Spliceosome NP_001103022 689890 10q26 rat S238-p 468705 SRGSPRYsPRHSRSR intracellular localization 18658135 1 39 17 inhibits tau exon 10 inclusion, and increases 3R-tau production -PDK1 PDHK1 EC 2.7.11.2; KINASE; Kinase, protein; Mitochondrial; Protein kinase, Ser/Thr (non-receptor); Protein kinase, atypical Q15118 5163 2q31.1 human T338-p 54390604 LFNYMYStAPRPRVE HATPase_c enzymatic activity, induced carcinogenesis, induced; cell growth, induced 26942675; 31578148 4 1 0 -Lat LAT Adaptor/scaffold; Membrane protein, integral O54957 16797 7|7 F3 mouse Y195-p 448005 SLDGSREyVNVSPEQ LAT molecular association, regulation; intracellular localization; phosphorylation cell adhesion, altered USP9X(INDUCES); Fyn(INDUCES) 15470052; 15699109; 17579183; 26936881 40 4 54 Localization of recruited PLCG2 to the membrane/cytoskeleton; proximity with TCR-associated ZAP70; Fyn may be involved in LAT phosphorylation. -CENPQ CENPQ Q7L2Z9 55166 6p12.3 human S50-p 18007851 KNHLKDLsSEGQTKH intracellular localization cell cycle regulation 25395579 1 8 0 regulation of chromosome congression mechanism -ITGB1 ITGB1 Cell adhesion; Cell surface; Membrane protein, integral; Motility/polarity/chemotaxis; Receptor, misc. P05556 3688 10p11.22 human K794-ac 11320212 VTTVVNPkYEGK___ Integrin_b_cyt acetylation cell adhesion, induced 32182705 1 4 0 acetylation promotes FN matrix assembly, integrin activation -ECD SGT1 Transcription, coactivator/corepressor O95905 11319 10q22.2 human S503-p 3178821 LGPRPNEsDSDDLDD SGT1 cell cycle regulation 26711270 1 7 0 -ETFB ETFB Mitochondrial; Oxidoreductase P38117 2109 19q13.41 human K203-m2 36974101 PNIMKAKkKKIEVIK ETF enzymatic activity, inhibited 25416781 1 1 0 inhibitory effect on the transfer of electrons -Thra TR-alpha iso2 DNA-binding; Nuclear receptor; Transcription factor P63059-2 81812 rat K283-sm 27490404 LSGEMAVkREQLKNG Hormone_recep transcription, altered 22930759 4 0 0 -H2AZ1 H2AZ DNA-binding P0C0S5 3015 4q23 human K4-ac 458911 ____AGGkAGKDSGK Histone transcription, induced 18985155 4 14 250 Myc-induced transcriptional activation -Crebbp CBP ACETYLTRANSFERASE; Acetyltransferase; DNA-binding; EC 2.3.1.48; Motility/polarity/chemotaxis; Nuclear receptor co-regulator; Transcription, coactivator/corepressor P45481 12914 16 A1|16 2.4 cM mouse K999-sm 3726905 DVPMLEMkTEVQTDD molecular association, regulation transcription, inhibited DAXX(INDUCES); HDAC2(INDUCES) 16287980 1 0 0 -LMNA lamin A/C Cytoskeletal P02545 4000 1q22 human K201-sm 8545502 ENRLQTMkEELDFQK Filament intracellular localization 18606848 1 0 0 increased cell death -MSH3 MSH3 DNA repair, damage P20585 4437 5q14.1 human K98-ac 9925423 LENDGPVkKKVKKVQ intracellular localization 32900932 1 0 1 -PTK2 FAK EC 2.7.10.2; KINASE; Kinase, protein; Protein kinase, TK; Protein kinase, tyrosine (non-receptor) Q00944 396416 chicken Y863-p 447965 PAGNQHIyQPVGKPD activity, induced; phosphorylation; enzymatic activity, induced 12370821; 9790958 75 21 307 -Cgas cGAS EC 2.7.7.86 Q8C6L5 214763 9|9 E1 mouse K217-sm 59117703 NEFDVMFkLEVPRIE Mab-21 protein stabilization 27637147 1 0 0 -PRMT5 PRMT5 Cell cycle regulation; EC 2.1.1.125; METHYLTRANSFERASE; Methyltransferase; Methyltransferase, protein arginine; RNA processing O14744 10419 14q11.2 human T144-p 1267669104 VLTNHIHtGHHSSMF PRMT5_TIM enzymatic activity, induced 30289978 1 0 0 -SMAD3 SMAD3 DNA-binding; Nuclear receptor co-regulator; Transcription factor P84022 4088 15q22.33 human S204-p 451178 NHSMDAGsPNLSPNP molecular association, regulation; intracellular localization; activity, inhibited transcription, induced; transcription, inhibited; signaling pathway regulation; transcription, altered; cell growth, altered TGFBR1(INDUCES) 10197981; 15520018; 16156666; 20659902; 20736297; 34003249; 34360888; 34504019 17 0 0 inhibits TGF-B signaling -CDKN1A p21Cip1 Cell cycle regulation; Inhibitor P38936 1026 6p21.2 human K161-ac 12615906 KRRLIFSkRKP____ protein stabilization; molecular association, regulation cell cycle regulation; carcinogenesis, inhibited; cell growth, inhibited C8A(DISRUPTS) 20154723; 23238566 2 1 0 induces senescence and DNA-damage-induced cell cycle arrest -ERGIC3 SDBCAG84 Membrane protein, integral; Membrane protein, multi-pass; Motility/polarity/chemotaxis; Vesicle Q9Y282 51614 20q11.22 human K6-ub 63727764 __MEALGkLKQFDAY protein degradation 31142615 1 4 0 trafficking and secretion of alpha1-antitrypsin and haptoglobin -MDM2 MDM2 EC 6.3.2.-; EC 6.3.2.19; Inhibitor; Ligase; NEDDYLATION LIGASE; Neddylation Ligase; Nucleolus; Oncoprotein; UBIQUITIN LIGASE; Ubiquitin conjugating system; Ubiquitin ligase Q00987 4193 12q15 human T419-p 448132 KEFEREEtQDKEESV molecular association, regulation; enzymatic activity, inhibited; protein conformation p53(DISRUPTS) 21986495 2 2 0 oligomerization inhibited -Shc1 SHC1 iso2 Adaptor/scaffold; Apoptosis; Mitochondrial; Motility/polarity/chemotaxis P98083-2 20416 3 F1|3 39.11 cM mouse Y313-p 448511 ELFDDPSyVNIQNLD molecular association, regulation; phosphorylation cell motility, induced; cell motility, altered; apoptosis, inhibited GRB2(INDUCES) 18273058; 23277357 42 91 1971 required for ErbB2- and TGFB mediated tumor metastasis to the lungs.; metastatic spread of tumors; required for migration and invasion of ERB2-expressing cells -STK4 MST1 Autophagy; EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, STE; Protein kinase, Ser/Thr (non-receptor) Q13043 6789 20q13.12 human S82-p 12057400 SIMQQCDsPHVVKYY Pkinase molecular association, regulation; intracellular localization; enzymatic activity, induced apoptosis, altered MST1(INDUCES) 20028971 1 0 0 -Ikzf1 Ikaros C2H2-type zinc finger protein; DNA-binding; Transcription factor Q03267 22778 11 A1|11 7.02 cM mouse S293-p 15404028 LSDMPYDsANYEKED molecular association, regulation; intracellular localization DNA(DISRUPTS) 18223295 1 1 1 -PITPNC1 PITPNC1 Lipid-binding Q9UKF7 26207 17q24.2 human S299-p 478664 KDRPRKKsAPETLTL activity, induced; protein stabilization; molecular association, regulation 14-3-3 beta(INDUCES); 14-3-3 epsilon(INDUCES) 21728994; 26977884 2 19 78 -STK3 MST2 Autophagy; EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, STE; Protein kinase, Ser/Thr (non-receptor) Q13188 6788 8q22.2 human T117-p 12615900 IIRLRNKtLIEDEIA Pkinase molecular association, regulation; intracellular localization; enzymatic activity, inhibited; phosphorylation carcinogenesis, induced; apoptosis, altered; signaling pathway regulation; cell growth, altered MST2(DISRUPTS); RASSF1(DISRUPTS); RAF1(INDUCES) 20086174; 20231902 2 0 1 inhibits MST2 T180 autophosphorylation -TTN Titin EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, CAMK; Protein kinase, Ser/Thr (non-receptor) Q8WZ42 7273 2q31.2 human Y32341-p 448692 LFTAPEYyAPEVHQH Pkinase enzymatic activity, induced 9804419 1 0 0 -Gli2 GLI2 C2H2-type zinc finger protein; Oncoprotein; Transcription factor Q0VGT2 14633 1 E2.3|1 52.17 cM mouse S662-p 57786400 GSAPNNDsGMEMPGT protein degradation transcription, inhibited; translation, inhibited 27484899 1 1 0 overexpression of GLI2 S662A stabilized and increased during mES cell differentiation enhances transcript expression -TET1 TET1 DNA-binding; EC 1.14.11.n2; Oxidoreductase Q8NFU7 80312 10q21.3 human T1164-p 1881549500 DRRKKKPtVVSYQEN protein stabilization carcinogenesis, induced; cell growth, induced; apoptosis, inhibited; transcription, induced 36989375 1 0 0 -Plekhg5 PLEKHG5 Q66T02 269608 4|4 E2 mouse S806-p 27434500 PTILRKSsNSLDSEH molecular association, regulation; intracellular localization MPDZ(DISRUPTS) 23253477 1 0 0 inhibits EC recruitment to cell junction -TRPC3 TRPC3 Channel, cation; Membrane protein, integral; Membrane protein, multi-pass Q13507 7222 4q27 human S785-p 454431 PPFSLVPsPKSFVYF activity, inhibited 15533987; 16331690 2 0 0 -GRK1 GRK1 EC 2.7.11.14; KINASE; Kinase, protein; Protein kinase, AGC; Protein kinase, Ser/Thr (non-receptor) P28327 281457 cow S488-p 2530401 IQDVGAFsTVKGVAF molecular association, regulation; enzymatic activity, inhibited PTN(DISRUPTS) 7797516 3 1 0 -DDAH2 DDAH2 Apoptosis; EC 3.5.3.18; Hydrolase O95865 23564 6p21.33 human S245-p 1872776106 GGGDLPNsQEALQKL intracellular localization; phosphorylation; enzymatic activity, induced signaling pathway regulation 33850055 1 1 0 regulates RLR signaling, regulates DRP1 anf IRF3 phosphorylation -APBA3 APBA3 Motility/polarity/chemotaxis O96018 9546 19p13.3 human S7-p 29668009 _MDFPTIsRSPSGPP molecular association, regulation cell growth, induced HIF1AN(INDUCES) 24164895 1 1 0 -H3c1 H3 DNA-binding P68433 360198 13|13 A3.1 mouse K9-m1 1458609 RTKQTARkSTGGKAP Histone endocytosis, altered; chromatin organization, altered; apoptosis, induced; cell adhesion, altered; transcription, inhibited 19910458; 33195484 34 19 14 regulates spermatogenesis, spermatid elongation-chromatin condensation in spermatids and germ cell apoptosis; axon guidance -HCK Hck EC 2.7.10.2; KINASE; Kinase, protein; Oncoprotein; Protein kinase, TK; Protein kinase, tyrosine (non-receptor) P08631 3055 20q11.21 human Y411-p 448168 RVIEDNEyTAREGAK PK_Tyr_Ser-Thr carcinogenesis, induced 34132782 13 70 2093 -NR5A2 NR5A2 DNA-binding; Nuclear receptor; Transcription factor O00482 2494 1q32.1 human S510-p 456465 LPEIRAIsMQAEEYL Hormone_recep activity, induced; intracellular localization transcription, induced 16109788; 37285077 2 0 0 -IRF9 IRF9 DNA-binding; Transcription factor Q00978 10379 14q12 human S253-p 1881230102 EPSGSESsMEQVLFP transcription, altered 36662450 1 1 0 -NR3C2 MCR DNA-binding; Nuclear receptor P08235 4306 4q31.23 human K89-sm 3144808 GILTSDIkTELESKE transcription, induced; transcription, inhibited 14500761; 17105732 3 0 0 Ubc9 can be a transcriptional mineralocorticoid receptor coactivator. -TARDBP TDP-43 RNA-binding Q13148 23435 1p36.22 human S404-p 3084635 FNGGFGSsMDSKSSG molecular association, regulation; intracellular localization; phosphorylation RNA splicing, inhibited; RNA stability, inhibited TDP-43(DISRUPTS) 22198567; 24466128; 34107054; 35112738 14 2 0 primes phosphorylation at other sites; promotes cytoplasmic aggregation -GLS glutaminase iso3 Amino Acid Metabolism - alanine, aspartate and glutamate; Amino Acid Metabolism - arginine and proline; EC 3.5.1.2; Energy Metabolism - nitrogen; Hydrolase; Mitochondrial; Other Amino Acids Metabolism - D-Glutamine and D-glutamate O94925-3 2744 2q32.2 human S314-p 937769500 RYVGKEPsGLRFNKL Glutaminase enzymatic activity, induced cell differentiation, inhibited; cell growth, induced 29515166 1 0 0 -MASTL MASTL EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, AGC; Protein kinase, Ser/Thr (non-receptor) Q96GX5 84930 10p12.1 human T299-p 1269647500 QSRKRLAtSSASSQS protein degradation; enzymatic activity, induced cell cycle regulation; carcinogenesis, induced 32123010 2 0 0 -RUNX3 AML2 DNA-binding; Transcription factor Q13761 864 1p36.11 human T212-p 3952612 RMRVTPStPSPRGSL protein degradation; molecular association, regulation; ubiquitination; activity, inhibited carcinogenesis, induced PIN1(INDUCES) 22580604 1 1 4 The downstream effects occur in the presence of PIN1 -SMAD3 SMAD3 DNA-binding; Nuclear receptor co-regulator; Transcription factor P84022 4088 15q22.33 human T388-p 1243500 GAEYRRQtVTSTPCW MH2 molecular association, regulation transcription, induced; transcription, inhibited CDK8(INDUCES); SMAD4(INDUCES); TUBB2B(INDUCES) 21868450; 24485922 3 1 0 ACTA2, collagen I, and fibronectin gene transcription ; cGMP-induced inhibition of SERPINE1 transcriptional activity -PKN3 PKN3 EC 2.7.11.13; KINASE; Kinase, protein; Protein kinase, AGC; Protein kinase, Ser/Thr (non-receptor) Q6P5Z2 29941 9q34.11 human T718-p 448346 GFGDRTStFCGTPEF Pkinase enzymatic activity, induced 15282551 2 4 62 -ARHGDIB RhoGDI beta Cell adhesion; G protein regulator, misc.; Motility/polarity/chemotaxis P52566 397 12p12.3 human Y24-p 448978 ELDSKLNyKPPPQKS Rho_GDI molecular association, regulation; intracellular localization carcinogenesis, induced; cell motility, induced CDC42(DISRUPTS); RHOA(DISRUPTS); RAC1(DISRUPTS); RHOC(DISRUPTS) 19321744; 31075185; 32903764 4 7 342 -GRM7 mGluR7 GPCR, family 3; Membrane protein, integral; Membrane protein, multi-pass; Receptor, GPCR Q14831 2917 3p26.1 human K889-sm 25042302 DRPNGEAkTELCENV sumoylation endocytosis, altered 26631532 2 0 0 -RB1 Rb Nuclear receptor co-regulator; Oncoprotein; Transcription, coactivator/corepressor; Tumor suppressor P06400 5925 13q14.2 human K810-m1 34823403 NIYISPLkSPYKISE Rb_C molecular association, regulation; protein conformation; phosphorylation cell cycle regulation; DNA repair, induced; carcinogenesis, inhibited; cell growth, inhibited; transcription, induced; transcription, inhibited PHF20L1(INDUCES); MYST1(INDUCES); 53BP1(INDUCES) 21119616; 25049398; 28841214 4 2 0 PHF20L1 shows more specificity for RbK810me1 -Stat3 STAT3 DNA-binding; Motility/polarity/chemotaxis; Nuclear receptor co-regulator; Transcription factor P42227 20848 11 D|11 63.82 cM mouse K685-ac 458927 PKEEAFGkYCRPESQ acetylation; intracellular localization; phosphorylation cell differentiation, induced; transcription, inhibited SIRT1(INDUCES) 19295512; 26923837; 28445726 27 2 0 nuclear localization; SIRT1 activation inhibitss Th17 cell differentiation through STAT3 deacetylation; SIRT1 downregulates phosphorylation at STAT3-Y705 and transactivation, deacetylation of STAT3 -RAB11FIP3 RAB11FIP3 O75154 9727 16p13.3 human S102-p 25126702 GPRGQLAsPDAPGPG intracellular localization 22401586 1 6 0 Phosphorylation at S102 leads to increase in number of binucleate cells and defective cytokinesis -POLR1E POLR1E Nucleolus; Nucleotide Metabolism - purine; Nucleotide Metabolism - pyrimidine Q9GZS1 64425 9p13.2 human K373-ac 11325050 KRMMEIAkAMRLKIS RNA_pol_I_A49 molecular association, regulation transcription, inhibited DNA(DISRUPTS) 24207024 1 1 0 hypoacetylation promotes Pol I transcription -SNAI2 Snail2 Apoptosis; C2H2-type zinc finger protein; Motility/polarity/chemotaxis; Transcription factor O43623 6591 8q11.21 human S100-p 25603907 DTSSKDHsGSESPIS protein degradation; intracellular localization cell motility, inhibited; transcription, induced CHIP(INDUCES) 22727060; 23851495 2 1 0 transcriptional activity of E-cadherin; Snail2 luciferase construct, may affect lung metastasis in NSCLC.; WT localized in nucleus and cytoplasm, mutants localize in nucleus; mutants enhance epithelial-mesenchymal transition (EMT) -PRKCZ PKCZ EC 2.7.11.13; KINASE; Kinase, protein; Protein kinase, AGC; Protein kinase, Ser/Thr (non-receptor) Q05513 5590 1p36.33 human Y428-p 482866 EILRGEEyGFSVDWW Pkinase protein conformation 17335005 1 0 0 -Epor EPOR Membrane protein, integral; Receptor, cytokine P14753 13857 9 A3|9 7.93 cM mouse Y484-p 3103701 GDSSDGPySHPYENS carcinogenesis, induced; cell growth, induced 27998978 3 0 0 STAT5 acivation -Igf2bp1 IGF2BP1 RNA-binding; Translation Q8CGX0 303477 10q26 rat S181-p 453893 RGQPRQGsPVAAGAP molecular association, regulation; intracellular localization KIF5A(DISRUPTS) RNA(INDUCES) 28500298 3 59 12 IGF2BP1 mobility -Grm5 mGluR5 GPCR, family 3; Membrane protein, integral; Membrane protein, multi-pass; Receptor, GPCR P31424 24418 1q32 rat T840-p 450487 RSAFTTStVVRMHVG receptor inactivation, altered; activity, inhibited 12681368; 14561742 2 4 2 -CLDN4 Claudin-4 Cytoskeletal; Membrane protein, integral; Membrane protein, multi-pass O14493 1364 7q11.23 human Y208-p 451666 RSAAASNyV______ molecular association, regulation cell adhesion, altered ZO1(DISRUPTS) 16236711 2 6 79 Phosphorylation of site increases paracellular permeability through tight junctions. -SIK2 QIK EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, CAMK; Protein kinase, Ser/Thr (non-receptor) Q9H0K1 23235 11q23.1 human S90-p 25120404 YQVMETKsMLYLVTE Pkinase enzymatic activity, induced 27478041 2 1 0 -PPARG PPAR-gamma iso2 DNA-binding; Nuclear receptor; Transcription factor P37231-2 5468 3p25.2 human K79-sm 3617602 QEYQSAIkVEPASPP PPARgamma_N carcinogenesis, inhibited; cell growth, inhibited; transcription, altered 26244663 15 0 0 -ADAM10 ADAM10 Cell adhesion; Cell surface; EC 3.4.24.81; Membrane protein, integral; Motility/polarity/chemotaxis; Protease; Vesicle O14672 102 15q21.3 human S436-p 4697183 NNKFSLCsIRNISQV Reprolysin_2 enzymatic activity, inhibited carcinogenesis, induced; cell motility, induced; cell adhesion, induced 36922678 1 2 0 induces N-cadherin stabilization -ITGB4 ITGB4 iso2 Cell adhesion; Membrane protein, integral; Motility/polarity/chemotaxis; Receptor, misc. P16144-2 3691 17q25.1 human Y1440-p 450141 STTLPRDySTLTSVS activity, induced; molecular association, regulation cell motility, altered; cell adhesion, altered PLCG1(INDUCES); SHC1(INDUCES) 11044453; 20855525; 33883672 6 11 166 promote SFK (Fyn) activation and tumor cell invasion -ZNRF2 ZNRF2 EC 6.3.2.-; EC 6.3.2.19; Ligase; UBIQUITIN LIGASE; Ubiquitin conjugating system; Ubiquitin ligase Q8NHG8 223082 7p14.3 human S19-p 3206973 NGRTRAYsGSDLPSS molecular association, regulation 14-3-3 beta(INDUCES) 19648646 1 32 9 yeast 14-3-3 used for binding assay -GMFG GMF-gamma Actin-binding O60234 9535 19q13.2 human Y104-p 33670301 KPEQQMMyAGSKNRL Cofilin_ADF molecular association, regulation; intracellular localization cell motility, induced; cytoskeletal reorganization ARPC3(DISRUPTS); ARP2(DISRUPTS) 24818551; 30811945 2 0 0 smooth muscle cell migration, regulates lamellipodial and focal adhesions; Actin polymerization and smooth muscle contraction regulation -RACGAP1 MgcRacGAP GAP; GAP, Rac/Rho Q9H0H5 29127 12q13.12 human T249-p 478691 WTRSRRKtGTLQPWN molecular association, regulation cell motility, induced IQGAP1(INDUCES) 24019536 2 5 58 drives pseudopod extension and invasive migration, suppression of Rac activity and concomitant activation of RhoA -Dnm2 DYN2 EC 3.6.5.5; Hydrolase; Microtubule-binding; Motility/polarity/chemotaxis; Vesicle P39054 13430 9 A3|9 7.79 cM mouse S848-p 3059607 GIPPGVPsRRAPAAP receptor internalization, induced; molecular association, regulation endocytosis, induced BIN1(DISRUPTS) 36445308 2 1 0 -ACBD5 ACBD5 iso2 Lipid-binding; Membrane protein, integral Q5T8D3-2 91452 10p12.1 human S263-p 1876128612 HLTSDSDsEVYCDSM molecular association, regulation; phosphorylation VAPB(INDUCES) 35019937 1 1 0 induces phosphorylation at S269 -HDAC7 HDAC7 DEACETYLASE; Deacetylase; EC 3.5.1.98; Hydrolase Q8WUI4 51564 12q13.11 human S358-p 455621 WPLSRTRsEPLPPSA intracellular localization cell motility, altered; cytoskeletal reorganization; transcription, altered; cell growth, altered 15623513; 18509061; 18617643 5 16 18 important for VEGF-induced aorta ring angiogenesis; nucleo-cytoplasmic shuttling -DVL1 DVL1 Inhibitor O14640 1855 1p36.33 human K69-ac 1880010900 EIFDDNAkLPCFNGR intracellular localization transcription, inhibited 31700102 1 1 0 nuclear localization -Syn1 SYN1 Vesicle P09951 24949 Xq11 rat T339-p 2020533 SGNWKTNtGSAMLEQ Synapsin_C molecular association, regulation; intracellular localization neural plasticity; signaling pathway regulation SYP(DISRUPTS) 31148170 1 2 0 regulating glutamate release -INSR INSR iso2 EC 2.7.10.1; KINASE; Kinase, protein; Membrane protein, integral; Protein kinase, TK; Protein kinase, tyrosine (receptor) P06213-2 3643 19p13.2 human Y1349-p 447684 SYEEHIPyTHMNGGK activity, inhibited cell cycle regulation 2026614 15 7 14 -AKT1 Akt1 EC 2.7.11.1; KINASE; Kinase, protein; Oncoprotein; Protein kinase, AGC; Protein kinase, Ser/Thr (non-receptor) P31749 207 14q32.33 human Y326-p 447858 EVLEDNDyGRAVDWW Pkinase enzymatic activity, induced 20606012 3 2 26 Brk induces Akt activation by phosphorylation on Y315,Y326. -TRIM33 TIF1G EC 6.3.2.-; EC 6.3.2.19; KINASE; Kinase, protein; Ligase; Protein kinase, atypical; Transcription, coactivator/corepressor; UBIQUITIN LIGASE; Ubiquitin conjugating system; Ubiquitin ligase Q9UPN9 51592 1p13.2 human Y524-p 15416086 QHMQQQVyAQKHQQL molecular association, regulation; intracellular localization transcription, induced; signaling pathway regulation SMAD3(DISRUPTS) 30177833 1 1 21 regulates TGFB-SMAD2/3 signaling and epithelial to mesenchymal transition -OGT OGT EC 2.4.1.255; Glycan Metabolism - O-glycan biosynthesis; O-GlcNAc TRANSFERASE; Transferase O15294 8473 Xq13.1 human S20-p 3174941 EPTKRMLsFQGLAEL protein stabilization; intracellular localization 29021254 3 15 7 OGT(S20A) attenuates vimentin O-GlcNAcylation and phosphorylation -STAT3 STAT3 DNA-binding; Motility/polarity/chemotaxis; Nuclear receptor co-regulator; Transcription factor P40763 6774 17q21.2 human K49-m2 40439803 DWAYAASkESHATLV STAT_int transcription, induced 25767098 1 1 0 -MLH1 MLH1 Cell cycle regulation; DNA repair, damage; Tumor suppressor P40692 4292 3p22.2 human K377-ub 573763756 STSGSSDkVYAHQMV molecular association, regulation MSH2(INDUCES); MSH6(INDUCES) 30770470 1 3 0 -NCOA3 SRC-3 ACETYLTRANSFERASE; Acetyltransferase; EC 2.3.1.48; Motility/polarity/chemotaxis; Nuclear receptor co-regulator; Transcription, coactivator/corepressor Q9Y6Q9 8202 20q13.12 human S728-p 3217881 VVKQEQLsPKKKENN DUF4927 intracellular localization 22163316 1 18 2 regulates SRC-3 access to condensed chromatin -BLM BLM DNA repair, damage; DNA replication; EC 3.6.4.12; Helicase P54132 641 15q26.1 human S175-p 23086547 SFVTPPQsHFVRVST BLM_N protein degradation; molecular association, regulation; ubiquitination FBXW7(INDUCES) 26028025 1 0 1 -TPH2 TPH2 Amino Acid Metabolism - tryptophan; EC 1.14.16.4; Oxidoreductase Q8IWU9 121278 12q21.1 human S104-p 1033700 RKSRRRSsEVEIFVD molecular association, regulation 14-3-3 epsilon(INDUCES); 14-3-3 gamma(INDUCES) 17973628 1 3 1 -PICK1 PICK1 Adaptor/scaffold; Cell development/differentiation; Ligand, receptor tyrosine kinase Q9NRD5 9463 22q13.1 human S415-p 50642302 KGGSWCDs_______ molecular association, regulation GluR2(INDUCES) 26472923 1 3 0 S415 was essential for binding to GluA2 -CTNNB1 CTNNB1 Actin-binding; Cell adhesion; Motility/polarity/chemotaxis; Nuclear receptor co-regulator; Oncoprotein; Transcription factor P35222 1499 3p22.1 human S29-p 3075000 VSHWQQQsYLDSGIH protein degradation cell motility, altered CTNNA1(INDUCES) 12432063 3 2 4 -IRF2 IRF2 DNA-binding; Transcription factor P14316 3660 4q35.1 human K137-sm 3173816 EDKVKHIkQEPVESS transcription, inhibited 18514056 1 2 0 -LARP6 LARP6 Q9BRS8 55323 15q23 human S451-p 485240 QEKSPGTsPLLSRKM protein degradation 26932461 1 20 0 collagen synthesis -IRAK1 IRAK1 EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, Ser/Thr (non-receptor); Protein kinase, TKL P51617 3654 Xq28 human S144-p 21041600 SSASTFLsPAFPGSQ molecular association, regulation; enzymatic activity, induced transcription, induced PIN1(INDUCES) 21743479; 27790836 2 1 0 -Slc22a1 SLC22A1 Membrane protein, integral; Membrane protein, multi-pass; Transporter; Transporter, SLC family Q63089 24904 1q11 rat S286-p 455610 YYWFVPEsPRWLLSQ Sugar_tr activity, induced 15829703 1 0 0 stimulates ASP+ uptake -RANBP9 RANBP9 Adaptor/scaffold; GAP; GAP, Ras; Nuclear receptor co-regulator Q96S59 10048 6p23 human S181-p 54363506 KFSYIGLsQNNLRVH intracellular localization 26943034 1 0 0 nuclear accumulation -Plcd1 PLCD1 Carbohydrate Metabolism - inositol phosphate; EC 3.1.4.11; Phospholipase P10688 rat S35-p 9993602 LLKVKSSsWRRERFY PH_12 enzymatic activity, induced 19681039 1 0 0 in vitro -RAC1 RAC1 G protein; G protein, monomeric; G protein, monomeric, Rho; Motility/polarity/chemotaxis P63000 5879 7p22.1 human T108-p 27458396 VRHHCPNtPIILVGT Ras molecular association, regulation; intracellular localization; enzymatic activity, inhibited RNA splicing, induced SFRS2(INDUCES); hnRNP A1(INDUCES); PLCG1(DISRUPTS); snRNP A'(INDUCES) 24043306; 33417283 4 1 0 -Syn1 SYN1 Vesicle P09951 24949 Xq11 rat T562-gl 5505102 QAGPPQAtRQASISG phosphorylation 10386995 1 1 0 in the presnce of two GlcNAcs CaM Kinase II activity had a 66% increase in KM with no effect on Vmax or Kcat -KRAS KRas iso2 G protein; G protein, monomeric; G protein, monomeric, Ras; Motility/polarity/chemotaxis; Oncoprotein P01116-2 3845 12p12.1 human S181-p 459210 GKKKKKKsKTKCVIM activity, induced; molecular association, regulation; intracellular localization; protein conformation; phosphorylation cell differentiation, inhibited; apoptosis, altered; carcinogenesis, altered; cell motility, induced; cell growth, induced; cell adhesion, altered; transcription, altered RAF1(DISRUPTS); PDE6D(DISRUPTS); RHOA(INDUCES); Calmodulin(DISRUPTS) 16483930; 18182391; 18458061; 20802526; 25713064; 27791178; 34333552; 34551282 10 0 0 regulates a-E-catenin localization -H2AC11 H2A.1 DNA-binding P0C0S8 8329 6p22.1 human T120-p 482914 AVLLPKKtESHHKAK Histone_H2A_C molecular association, regulation; intracellular localization cell cycle regulation; carcinogenesis, induced; cell growth, induced; chromatin organization, altered; transcription, induced; transcription, inhibited SGO1(INDUCES) DNA(INDUCES) 20929775; 24055156; 26190260; 26399325; 27716482; 30112853; 34312968; 34925867 15 8 0 -Ncor1 N-CoR1 Nuclear receptor co-regulator; Transcription, coactivator/corepressor Q60974 20185 11|11 B2 mouse K1330-sm 3755602 LKYPKQIkRESPPIR transcription, inhibited 16421255 1 0 0 -ETV4 ETV4 DNA-binding P43268 2118 17q21.31 human S73-p 68524600 AEAQVPDsDEQFVPD ETS_PEA3_N protein stabilization; molecular association, regulation COP1(DISRUPTS) 28373072 1 0 0 -CDC7 CDC7 EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, Other; Protein kinase, Ser/Thr (non-receptor) O00311 8317 1p22.2-p22.1 human T376-p 2864203 QVAPRAGtPGFRAPE Pkinase protein degradation; ubiquitination; enzymatic activity, induced 10846177; 27611229 3 1 12 -DDR1 DDR1 EC 2.7.10.1; KINASE; Kinase, protein; Membrane protein, integral; Protein kinase, TK; Protein kinase, tyrosine (receptor) Q08345 780 6p21.33 human Y796-p 457957 RNLYAGDyYRVQGRA PK_Tyr_Ser-Thr activity, induced; molecular association, regulation SHP-2(INDUCES) 16611743; 24509848 2 16 939 phosphorylated in the N211QDDR1 mutant; required for the DDR1-mediated suppression of tyrosine phosphorylation of Stat1 and Stat3, cell migration, branching tubulogenesis -WDR5 WDR5 Adaptor/scaffold P61964 11091 9q34.2 human S49-p 25758598 AGHTKAVsSVKFSPN WD40 cell differentiation, induced; transcription, induced 31072927 1 0 1 myogenesis indeced -Nfatc2 NFAT1 DNA-binding; Transcription factor Q60591 18019 2 H3|2 88.91 cM mouse S182-p 449625 GSSASFIsDTFSPYT transcription, inhibited 11030334 0 1 0 -CDCA5 CDCA5 Cell cycle regulation Q96FF9 113130 11q13.1 human S83-p 3208977 PRRSPRIsFFLEKEN activity, inhibited cell cycle regulation SCC-112(DISRUPTS) 23901111 2 14 0 -CHN2 ARHGAP3 GAP; GAP, Rac/Rho P52757 1124 7p14.3 human S171-p 13790300 EKVSRRLsRSKNEPR molecular association, regulation; intracellular localization; activity, inhibited cell motility, altered RAC1(NOT_REPORTED) 20335173 1 1 0 -CORO1C coronin 1C Actin-binding; Motility/polarity/chemotaxis Q9ULV4 23603 12q24.11 human S463-p 22996300 CNQDERIsKLEQQMA cell growth, inhibited; cell adhesion, induced; cytoskeletal reorganization; cell motility, inhibited 22355754; 23410663 2 0 0 decreased matrix degradation and invasion, increased invadopodia-like extensions in vitro -Wwox WWOX Apoptosis; EC 1.1.1.-; Oxidoreductase; Tumor suppressor Q91WL8 80707 8|8 E1 mouse Y33-p 449043 TTKDGWVyYANHTEE WW molecular association, regulation apoptosis, induced ERK2(INDUCES); ERK1(INDUCES); ZFRA(INDUCES); IkB-alpha(INDUCES) 17567906; 27339895 21 1 0 -Map2 MAP2 iso3 Cytoskeletal; Motility/polarity/chemotaxis P15146-3 25595 9q32 rat K283-ac 62495510 ILVPSEKkVAIIRTP cytoskeletal reorganization 28002468 1 1 0 -ATM ATM DNA repair, damage; EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, Ser/Thr (non-receptor); Protein kinase, atypical; Tumor suppressor Q13315 472 11q22.3 human T1985-p 481859 EEGSQSTtISSLSEK enzymatic activity, inhibited; protein conformation cell cycle regulation; apoptosis, inhibited 27939942 1 1 0 -Tesk1 TESK1 EC 2.7.12.1; KINASE; Kinase, protein; Protein kinase, Ser/Thr (non-receptor); Protein kinase, TKL; Protein kinase, dual-specificity (non-receptor) Q63572 29460 5q22 rat S215-p 452045 EPLAVVGsPYWMAPE PK_Tyr_Ser-Thr enzymatic activity, induced 10207045 1 0 0 in vitro assay -CFTR CFTR Channel, chloride; EC 3.6.3.49; Hydrolase; Membrane protein, integral; Membrane protein, multi-pass; Transporter; Transporter, ABC family P13569 1080 7q31.2 human S686-p 449980 WTETKKQsFKQTGEF CFTR_R activity, induced; protein conformation 12588899; 14695900; 32123855 5 0 0 -KMT5A SETD8 Amino Acid Metabolism - lysine degradation; EC 2.1.1.43; METHYLTRANSFERASE; Methyltransferase; Methyltransferase, protein lysine Q9NQR1 387893 12q24.31 human K172-sm 25090302 LVPFPNQkSEAAEPP transcription, inhibited 21829513 1 0 0 -ELAVL1 HuR RNA-binding Q15717 1994 19p13.2 human S202-p 3197192 LLSQLYHsPARRFGG molecular association, regulation; intracellular localization cell cycle regulation; apoptosis, induced; RNA stability, inhibited; translation, inhibited 14-3-3 theta(INDUCES) RNA(DISRUPTS) 18593881; 22829587; 25088200; 27303922; 30154469; 32047552 9 57 61 recruitmentof miR-4312 and competes HuR to bind to IL-8 transcrip; regulates centrosome function, Cyclin A translation inhibited -FANCA FANCA DNA repair, damage O15360 2175 16q24.3 human S347-p 56793101 VQMQREWsFARTHPL Fanconi_A_N ubiquitination 27449087 1 0 0 -CCT2 CCT2 Chaperone P78371 10576 12q15 human S260-p 472352 GSRVRVDsTAKVAEI Cpn60_TCP1 cell growth, altered 19332537 3 19 249 regulates cell proliferation -MAP3K8 Cot EC 2.7.11.25; KINASE; Kinase, protein; Oncoprotein; Protein kinase, STE; Protein kinase, Ser/Thr (non-receptor) P41279 1326 10p11.23 human S400-p 447712 EDQPRCQsLDSALLE transcription, altered 12138205 4 2 0 -RALA RALA G protein; G protein, monomeric; G protein, monomeric, Ras; Motility/polarity/chemotaxis P11233 5898 7p14.1 human S183-p 483988 RARKMEDsKEKNGKK enzymatic activity, induced carcinogenesis, induced; cell growth, induced 17540176 2 1 0 -HSF1 HSF1 DNA-binding; Transcription factor Q00613 3297 8q24.3 human S303-p 449045 RVKEEPPsPPQSPRV Vert_HS_TF sumoylation; molecular association, regulation; intracellular localization; protein processing; activity, inhibited transcription, inhibited; transcription, altered 14-3-3 epsilon(INDUCES); SUMO1(INDUCES) 12665592; 12917326; 16371476; 25963659; 33493517; 8940068 23 59 5 -RAB5A RAB5A G protein; G protein, monomeric; G protein, monomeric, Rab; Motility/polarity/chemotaxis P20339 5868 3p24.3 human T7-p 33622402 _MASRGAtRPNGPNT intracellular localization cell motility, induced; cytoskeletal reorganization 24872409 1 0 0 -TRAF6 TRAF6 EC 6.3.2.-; Ligase; UBIQUITIN LIGASE; Ubiquitin conjugating system; Ubiquitin ligase Q9Y4K3 7189 11p12 human T266-p 1867864101 ARHLQENtQSHMRML protein degradation; protein stabilization; ubiquitination carcinogenesis, induced; cell motility, induced; autophagy, inhibited 30806153 1 1 0 stabilises CTNNB1 -PIK3R2 PIK3R2 Kinase, lipid; Motility/polarity/chemotaxis O00459 5296 19p13.11 human K598-sm 56709101 INEWLGIkNETEDQY phosphorylation carcinogenesis, inhibited; signaling pathway regulation 26411363 1 0 0 sumolation inhibits PI3KR2 phosphorylation, regulates PI3K pathway activation -Bmal1 BMAL1 DNA-binding; Transcription factor Q9WTL8 11865 7 F1|7 59.17 cM mouse S418-gl 27583502 KFKIKDGsFITLRSR PAS_11 protein stabilization; ubiquitination 23395176 1 0 0 inhibits ubiquitination -CPLX2 CPLX2 Vesicle P84088 281711 cow S115-p 474556 EEEEEEEsILDTVLK Synaphin molecular association, regulation STX1A(INDUCES) 17266930 1 1 0 SNARE complex summarized by Syntaxin binding. -KDM5A JARID1A DEMETHYLASE; Demethylase; EC 1.14.11.-; Nuclear receptor co-regulator; Nucleolus; Oxidoreductase; Transcription factor P29375 5927 12p13.33 human T1225-p 56630500 SRRPRLEtILSLLVS intracellular localization 27292631 1 0 0 JARID1A recruitment to the promoters of AKT-regulated genes -Shc1 SHC1 Adaptor/scaffold; Apoptosis; Mitochondrial; Motility/polarity/chemotaxis P98083 20416 3 F1|3 39.11 cM mouse S36-p 448508 TPPEELPsPSASSLG intracellular localization; phosphorylation apoptosis, altered; apoptosis, induced; transcription, inhibited; transcription, altered 15930121; 16487929; 17077388; 18174162; 19060130; 20547441 20 1 0 induced by cisplatin -HMGN1 HMGN1 DNA-binding; Nuclear receptor co-regulator P05114 3150 21q22.2 human K53-ac 458850 SDKKVQTkGKRGAKG HMG14_17 molecular association, regulation DNA(DISRUPTS) 10753971 1 0 0 -NR3C2 MCR DNA-binding; Nuclear receptor P08235 4306 4q31.23 human S238-p 25692902 QGTPLTCsPNVENRG protein degradation; ubiquitination transcription, inhibited 22798426 1 0 0 -RAF1 RAF1 EC 2.7.11.1; KINASE; Kinase, protein; Oncoprotein; Protein kinase, Ser/Thr (non-receptor); Protein kinase, TKL P05625 396245 chicken S338-p 447742 RPRGQRDsSYYWEIE intracellular localization; enzymatic activity, induced apoptosis, inhibited 12843393; 12952943 92 2 7 -ETV5 ERM DNA-binding; Transcription factor P41161 2119 3q27.2 human K89-sm 2887207 APPPTKIkRELHSPS ETS_PEA3_N transcription, inhibited 15857832; 18243147 2 0 0 -SLC12A3 NCCT Membrane protein, integral; Membrane protein, multi-pass; Transporter; Transporter, SLC family P55017 6559 16q13 human K909-ub 27200746 NPRAEHTkRFEDMIA SLC12 protein degradation; ubiquitination; activity, inhibited; phosphorylation endocytosis, induced 29021560 1 1 0 NCC transport activity decreased. phosphorylation inhibited -Mapkapk5 MAPKAPK5 EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, CAMK; Protein kinase, Ser/Thr (non-receptor); Tumor suppressor O54992 17165 5|5 F mouse K364-ac 28070703 NPILRKRkLLGTKPK enzymatic activity, induced carcinogenesis, inhibited; cell growth, inhibited 23685072 1 0 0 oncogene-induced senescence -NEDD9 Cas-L Adaptor/scaffold; Motility/polarity/chemotaxis Q14511 4739 6p24.2 human S780-p 348338200 RNKVMNSsNQLCEQL CAS_C molecular association, regulation; intracellular localization cell motility, induced PLK1(NOT_REPORTED) 29191835 1 1 0 localization of HEF1 to FAs -Nfat5 NFAT5 Transcription factor Q9WV30 54446 8 D3|8 53.93 cM mouse S155-p 2715402 PEDLLDNsRMSCQDE intracellular localization 22992674 3 4 2 regulates nuclear localization -NCOR2 SMRT Nuclear receptor co-regulator; Transcription, coactivator/corepressor Q9Y618 9612 12q24.31 human S2407-p 454664 AKVSGRPsSRKAKSP protein degradation; intracellular localization transcription, induced 15494311 1 0 0 -DAP DAP Autophagy P51397 1611 5p15.2 human S3-p 14572132 _____MSsPPEGKLE activity, inhibited autophagy, altered 20537536 1 15 0 dephosphorylated form of DAP acts as an active suppressor of autophagy -Wwox WWOX Apoptosis; EC 1.1.1.-; Oxidoreductase; Tumor suppressor Q91WL8 80707 8|8 E1 mouse S14-p 454203 AGLDDTDsEDELPPG protein degradation 27339895 2 26 6 IkB-alpha degradation -ARHGDIA RhoGDI alpha Apoptosis; Cell adhesion; Cell development/differentiation; G protein regulator, misc.; Motility/polarity/chemotaxis P52565 396 17q25.3 human K138-sm 31089519 HTYRKGVkIDKTDYM Rho_GDI phosphorylation cell cycle regulation; carcinogenesis, inhibited; cell growth, inhibited; transcription, inhibited; signaling pathway regulation 24342356 2 2 0 downregulation of Cyclin D1 expression, and MEK1/2/Erk inhibition of C-Jun/AP1, repression of cyclin D1 transcription -NPM1 NPM1 Nucleolus; Oncoprotein; RNA-binding; Translation P06748 4869 5q35.1 human K215-ac 8537512 NQNGKDSkPSSTPRS molecular association, regulation; intracellular localization transcription, altered H3(INDUCES) 19581289 1 5 0 K212/215/229/230/257/267/292R mutant -Kif3a KIF3A Microtubule-binding; Motor P28741 16568 11 B1.3|11 31.97 cM mouse T674-p 33668514 MKLERPRtSKGKARP autophagy, inhibited; signaling pathway regulation 32935890 3 0 0 mildly affects cilia length, Hedgehog signaling and autophagy -MRPL10 MRPL10 Mitochondrial; Ribosomal; Translation Q3MHY7 515014 cow K169-ac 12674402 KEMVRILkSVPFLPL Ribosomal_L10 translation, induced 20042612 1 1 0 downregulates protein synthesis -Irak1 IRAK1 EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, Ser/Thr (non-receptor); Protein kinase, TKL B2RYH5 363520 Xq37 rat K355-ub 7452908 LDERLMPkLGDFGLA Pkinase protein degradation 21708940 2 4 0 -Map2 MAP2 iso3 Cytoskeletal; Motility/polarity/chemotaxis P15146-3 25595 9q32 rat K338-ac 62495504 QVQIVTKkIDLSHVT Tubulin-binding cytoskeletal reorganization 28002468 1 1 0 -Rag2 RAG2 Cell development/differentiation; Histone-binding; Lipid-binding P21784 19374 2 E2|2 53.87 cM mouse T490-p 455560 QIARALQtPKRNPPL RAG2_PHD protein degradation; molecular association, regulation; intracellular localization Other(DISRUPTS) 12205088; 31075127 4 0 0 T490A mutation reduces RAG2 rate of diffusion in the nucleus; T490A mutation increases RAG2 colocalization with H3K4me3 -AKAP8 AKAP8 Adaptor/scaffold; Cell cycle regulation; Mitochondrial; RNA-binding O43823 10270 19p13.12 human Y80-p 40420001 PAMHMASyGPEPCTD molecular association, regulation 25770215 1 0 0 Phenylalanine mutants inhibited dissociation from nuclear structures; structural chromatin changes -Map2 MAP2 iso3 Cytoskeletal; Motility/polarity/chemotaxis P15146-3 25595 9q32 rat K298-ac 62495517 PKSPATPkQLRLINQ cytoskeletal reorganization 28002468 1 1 0 -GARS1 GARS Aminoacyl-tRNA synthetase; EC 6.1.1.14; Ligase; Mitochondrial; Translation; Translation regulation P41250 2617 7p14.3 human K553-ub 10839688 GKTFQLTkDMINVKR tRNA-synt_2b protein degradation 26676607 0 3 1 -ANAPC1 APC1 Cell cycle regulation; Ubiquitin conjugating system Q9H1A4 64682 2q13 human S355-p 455825 AALSRAHsPALGVHS activity, induced; activity, inhibited cell cycle regulation 14657031; 29084198 2 39 2 -HNRNPK hnRNP K iso2 RNA splicing; RNA-binding; Spliceosome P61978-2 3190 9q21.32 human S116-p 452369 EEGLQLPsPTATSQL intracellular localization 20960454 4 38 22 -Ccnt1 CCNT1 Cell cycle regulation; Transcription initiation complex Q9QWV9 12455 15|15 F1 mouse K390-ac 11322420 PSAKVSLkEYRAKHA molecular association, regulation; enzymatic activity, induced transcription, induced BCDIN3(DISRUPTS); HEXIM1(DISRUPTS) 19387490 3 2 0 enhances CDK9/cyclin T1 transcriptional activity, disrupting HEXIM1 and BCDIN3 association -APAF1 APAF Apoptosis O14727 317 12q23.1 human S357-p 23003807 FKRIRKSsSYDYEAL NB-ARC molecular association, regulation CYC1(INDUCES) 22246185 1 0 0 -ADRB2 ADRB2 GPCR, family 1; Membrane protein, integral; Membrane protein, multi-pass; Receptor, GPCR P07550 154 5q32 human S356-p 458917 AYGNGYSsNGNTGEQ receptor internalization, induced; protein degradation; molecular association, regulation; receptor desensitization, altered; intracellular localization; receptor internalization, altered; protein conformation cell motility, induced; signaling pathway regulation ARR3(INDUCES); ARRB2(INDUCES) 11040066; 16407241; 16980556; 18801735; 20193676; 20345371; 21868357; 22275358; 25395624; 31088898 27 2 0 B-arrestin recruitment; B-arrestin mediated signaling -RAD50 RAD50 Adaptor/scaffold; DNA repair, damage; EC 3.6.-.-; Hydrolase Q92878 10111 5q31.1 human S635-p 453831 KLFDVCGsQDFESDL intracellular localization cell cycle regulation 21757780 3 20 11 sites of DNA damage, mediates DNA repair -BAX BAX Apoptosis; Membrane protein, integral; Mitochondrial; Tumor suppressor Q07812 581 19q13.33 human T186-p 28847909 GVLTASLtIWKKMG_ TM intracellular localization apoptosis, induced 23907458 1 0 0 -AKT2 Akt2 EC 2.7.11.1; KINASE; Kinase, protein; Oncoprotein; Protein kinase, AGC; Protein kinase, Ser/Thr (non-receptor) P31751 208 19q13.2 human S474-p 448520 RTHFPQFsYSASIRE Pkinase_C intracellular localization; enzymatic activity, induced signaling pathway regulation 11507039; 19277985; 26711268; 9374542 37 9 55 involved in SH2B1/PSM regulated insulin signaling pathway -KNG1 KNG1 Cell adhesion; Contractile; Inhibitor; Motility/polarity/chemotaxis; Secreted; Secreted, signal peptide P01042 3827 3q27.3 human S391-p 5024713 GFSPFRSsRIGEIKE protein processing 18844446 1 0 0 inhibits cleavage by kallikrein in vitro -CDC25A CDC25A EC 3.1.3.48; Motility/polarity/chemotaxis; PHOSPHATASE; Protein phosphatase, dual-specificity P30304 993 3p21.31 human S519-p 26342101 KSKREMYsRLKKL__ protein degradation cell cycle regulation 21376736 1 1 0 proteasome mediated degradation -Bcar1 P130Cas iso2 Adaptor/scaffold; Motility/polarity/chemotaxis Q63767-2 25414 19q12 rat Y253-p 448721 APGSQDIyDVPPVRG cell motility, altered 12972425 14 44 723 -Taok2 TAO2 Apoptosis; EC 2.7.11.1; KINASE; Kinase, protein; Membrane protein, integral; Membrane protein, multi-pass; Protein kinase, STE; Protein kinase, Ser/Thr (non-receptor) Q6ZQ29 381921 7|7 F3 mouse T475-p 23150863 RNRDHFAtIRTASLV molecular association, regulation cytoskeletal reorganization MYL5(INDUCES); DBN1(INDUCES) 25456499 1 1 1 spine development -STK11 LKB1 Autophagy; EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, CAMK; Protein kinase, Ser/Thr (non-receptor); Tumor suppressor Q15831 6794 19p13.3 human T336-p 448150 KDRWRSMtVVPYLED enzymatic activity, induced 12805220 2 0 0 STRAD increases LKB1 activation -DDX21 DDX21 EC 3.6.4.13; Helicase; Nucleolus; RNA processing; RNA-binding Q9NR30 9188 10q22.1 human K600-ac 36296739 HFKQSAEkLIEEKGA enzymatic activity, inhibited transcription, inhibited 28790157 1 0 0 Inhibits DDX21 helicase activity, impairs genomic stability, R-loop mediated stalling of RNA polymerase -TRIM50 TRIM50 EC 6.3.2.-; Ligase; UBIQUITIN LIGASE; Ubiquitin conjugating system; Ubiquitin ligase Q86XT4 135892 7q11.23 human K373-ac 31914104 IKGTASRkGKLNRSP SPRY ubiquitination; intracellular localization 24308962 1 0 0 inhibits ubiquitination -PCYT1A PCYT1A EC 2.7.7.15; Lipid Metabolism - glycerophospholipid; Transferase P49585 5130 3q29 human Y359-p 463968 SRHKAAAyDISEDEE intracellular localization 32186954 2 2 35 -SPRY2 SPRY2 Adaptor/scaffold; Inhibitor; Motility/polarity/chemotaxis O43597 10253 13q31.1 human S112-p 465675 APLSRSIsTVSSGSR protein degradation; molecular association, regulation; protein stabilization; ubiquitination BRAF(DISRUPTS); NEDD4 iso4(INDUCES) 16479008; 19690147; 19864419; 37045830 5 2 1 -GATA1 GATA1 DNA-binding; Transcription factor P15976 2623 Xp11.23 human K312-ac 459079 RNRKASGkGKKKRGS molecular association, regulation transcription, altered DNA(INDUCES) 16888089 6 1 0 -FUNDC1 FUNDC1 Membrane protein, multi-pass; Mitochondrial Q8IVP5 139341 Xp11.3 human Y18-p 11086746 YESDDDSyEVLDLTE molecular association, regulation; protein conformation autophagy, induced; autophagy, inhibited LC3B(DISRUPTS) 24746696; 27653272; 27757847 6 3 0 mitophagy inhibited, weakens the binding affinity due to electrostatic repulsion; Y18A mutation abolishes mitophagic activity -Nefm NFM Cytoskeletal P08553 18040 14|14 D1 mouse S669-p 448045 ADKKKAEsPVKEKAV cytoskeletal reorganization 19193875 4 23 1 slightly altered axoplasmic organization in 7S/A mice mutant -DYNLRB1 DYNLRB1 Motility/polarity/chemotaxis Q9NP97 83658 20q11.22 human S73-p 27523608 LTFLRIRsKKNEIMV Robl_LC7 molecular association, regulation transcription, induced DNCLI1(INDUCES) 23333499 1 0 0 -ATR ATR EC 2.7.11.1; KINASE; Kinase, protein; Membrane protein, integral; Protein kinase, Ser/Thr (non-receptor); Protein kinase, atypical Q13535 545 3q23 human T1989-p 2226546 LCFPENEtPPEGKNM FAT molecular association, regulation; phosphorylation; enzymatic activity, induced cell cycle regulation; carcinogenesis, induced; cell growth, induced; chromatin organization, altered; apoptosis, inhibited TOPBP1(INDUCES) 21705319; 21777809; 24876101; 28592488; 33848395; 34676045; 35798878 20 16 36 -AGO2 AGO2 EC 3.1.26.n2; RNA processing; RNA-binding Q9UKV8 27161 8q24.3 human S828-p 31082605 EHDSAEGsHTSGQSN molecular association, regulation; activity, inhibited; phosphorylation transcription, inhibited RNA(DISRUPTS) 28114302 3 4 0 regulates miRNA silencing; induces phosphorylation at S831 -Hcn4 HCN4 Channel, cation; Membrane protein, integral; Membrane protein, multi-pass O70507 330953 9|9 B mouse Y554-p 1240810 TRQRIHDyYEHRYQG activity, induced 16079136 2 0 0 Y476F mutation in Hcn2 and Y554F mutation in Hcn4, abolishes the effect of PP2 on activation. -ACLY ACLY Carbohydrate Metabolism - citrate (TCA) cycle; EC 2.3.3.8; Lyase; Transferase P53396 47 17q21.2 human K540-ub 59144800 FTGDHKQkFYWGHKE CoA_binding protein degradation carcinogenesis, inhibited; cell growth, inhibited 27664236 1 0 0 -CFL1 Cofilin-1 Cytoskeletal; Motility/polarity/chemotaxis; Nuclear receptor co-regulator P23528 1072 11q13.1 human Y68-p 449642 GQTVDDPyATFVKML Cofilin_ADF protein degradation; ubiquitination cell motility, altered; cytoskeletal reorganization 19802004 1 19 480 inhibits cofilin activity to reduce F-actin contents -H3C1 H3 DNA-binding P68431 8350 6p22.2 human K14-ac 458954 ARKSTGGkAPRKQLA Histone activity, induced; molecular association, regulation; intracellular localization; protein conformation; enzymatic activity, induced cell cycle regulation; carcinogenesis, induced; carcinogenesis, inhibited; apoptosis, induced; cell growth, inhibited; transcription, induced; transcription, altered; neural plasticity; DNA repair, induced; chromatin organization, altered; cell differentiation, induced; cell growth, induced; transcription, inhibited polybromo 1(INDUCES); SMARCA2(INDUCES); SMARCC2(INDUCES); 14-3-3 zeta(INDUCES); BRD7(INDUCES); MLL(INDUCES); SMARCA4(INDUCES); requiem(INDUCES); DPF3(INDUCES); BRD4(INDUCES); TIF1G(INDUCES) DNA(INDUCES); DNA(DISRUPTS) 12039950; 16354694; 17305432; 17409387; 17498659; 17560255; 17567990; 18179771; 18234970; 18418070; 18418385; 18985155; 19229332; 19828451; 19889207; 20043883; 20068219; 20080105; 20094059; 20159609; 20224553; 20368734; 20613843; 20720004; 20829218; 21097519; 21196933; 21726812; 21791614; 22144178; 22408259; 23287868; 23653357; 23844048; 26967163; 28167529; 28716899; 31822509; 32188943; 32623337; 32733069; 33408182; 35222362; 36060800; 36165173 162 31 355 p53 regulates histone H3K27me3 and H3K9/K14ac in the miR-1246 promoter dependent on recruited JMJD3/EP300/CBP. -KIF2B KIF2B Microtubule-binding; Motor Q8N4N8 84643 17q22 human S200-p 25247531 EYRRHLDsSKISVLE intracellular localization cell cycle regulation 22535524 1 1 0 -RBL2 Rb-like 2 Transcription, coactivator/corepressor; Tumor suppressor Q08999 5934 16q12.2 human S1044-p 449739 YPFVRTGsPRRIQLS molecular association, regulation cell cycle regulation E2F4(DISRUPTS) 11157749; 12006580 2 1 9 -EPAS1 HIF2A DNA-binding; Transcription factor Q99814 2034 2p21 human S435-p 1874020200 GKAILPPsQPWATEL protein stabilization; molecular association, regulation; ubiquitination carcinogenesis, induced; cell growth, induced; transcription, induced EGLN1(DISRUPTS) 34211090 1 1 0 inhibits ubiquitination -EIF4ENIF1 4E-T Karyopherin; Nuclear import; Translation Q9NRA8 56478 22q12.2 human S374-p 7322864 GLEQAILsPGQNSGN EIF4E-T molecular association, regulation 4E-T(INDUCES) 22966201 1 15 24 required for processing bodies (PBs or P bodies) assembly -Nos1 nNOS Amino Acid Metabolism - arginine and proline; EC 1.14.13.39; Oxidoreductase P29476 24598 12q16 rat K33-ac 2459104 GGLGFLVkERVSKPP PDZ activity, induced 18415985 2 1 0 -CLASP2 CLASP2 Cytoskeletal; Motility/polarity/chemotaxis O75122 23122 3p22.3 human S1013-p 4753159 HSMPTHSsPRSRDYN molecular association, regulation; phosphorylation cell cycle regulation; cytoskeletal reorganization PLK1(INDUCES) 23045552 1 15 2 primes for phosphorylation at other sites -SLC4A4 SLC4A4 Membrane protein, integral; Membrane protein, multi-pass; Transporter; Transporter, SLC family Q9Y6R1 8671 4q13.3 human S235-p 4699765 GKTVSSAsRMFTNPD Band_3_cyto protein conformation; activity, inhibited 30377224 1 8 0 -GALNT2 GALNT2 EC 2.4.1.41; Glycan Metabolism - O-glycan biosynthesis; Membrane protein, integral; Transferase Q10471 2590 1q42.13 human K363-ac 25336506 RVGHVFRkQHPYTFP enzymatic activity, inhibited; O-GalNAc glycosylation 21651894 0 1 0 inhibits glycosylation of mucin -Nfatc2 NFAT1 DNA-binding; Transcription factor Q60591 18019 2 H3|2 88.91 cM mouse S179-p 447844 ASSGSSAsFISDTFS transcription, inhibited 11030334 0 1 0 -Mapk13 P38D EC 2.7.11.24; KINASE; Kinase, protein; Protein kinase, CMGC; Protein kinase, Ser/Thr (non-receptor) Q9Z1B7 26415 17|17 A3.3 mouse T180-p 4787496 RHTDTEMtGYVVTRW Pkinase enzymatic activity, induced 10066767; 9374491 4 7 382 -SIRT1 SIRT1 Apoptosis; DEACETYLASE; Deacetylase; EC 3.5.1.-; Nuclear receptor co-regulator Q96EB6 23411 10q21.3 human T530-p 6006905 YLSELPPtPLHVSED molecular association, regulation; acetylation; intracellular localization; enzymatic activity, induced cell cycle regulation; autophagy, induced; cytoskeletal reorganization ATG7(INDUCES); PABP 1(INDUCES); REG3G(DISRUPTS) 19107194; 20027304; 24011073; 28756945; 30517871 7 3 40 suppress centriole duplication -PTPN5 STEP EC 3.1.3.48; Membrane protein, multi-pass; Motility/polarity/chemotaxis; PHOSPHATASE; Protein phosphatase, tyrosine (non-receptor) P54829 84867 11p15.1 human S245-p 448294 GLQERRGsNVSLTLD protein stabilization; molecular association, regulation; enzymatic activity, inhibited ERK1(DISRUPTS); ERK2(DISRUPTS) 20427654; 21777200; 26574547 9 0 0 -Sox6 SOX6 DNA-binding P40645 20679 7 F1|7 61.29 cM mouse T119-p 4706790 MNSVTFGtPERRKGS apoptosis, induced 24662752 1 4 0 CDK5 post-translational regulation of Sox6 expression, CDK5 hyperactivity leading to neuronal apoptosis -Neurog2 neurogenin 2 Transcription factor P70447 11924 3|3 G2 mouse Y241-p 457462 SPGSDVDyWQPPPPE cell motility, altered 16202708 1 0 0 Phosphorylation required for cortical neuron migration and cell body translocation. Phenotypes partially rescued by expression of dominant negative RhoA. -MAPKAPK5 MAPKAPK5 EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, CAMK; Protein kinase, Ser/Thr (non-receptor); Tumor suppressor Q8IW41 8550 12q24.12-q24.13 human S386-p 1876193502 HENGAEDsNVALEKL enzymatic activity, induced 35064619 1 1 0 -TRIM28 TIF1B EC 6.3.2.-; KINASE; Kinase, protein; Ligase; Nuclear receptor co-regulator; Protein kinase, atypical; SUMO LIGASE; SUMO ligase; Transcription, coactivator/corepressor; UBIQUITIN LIGASE; Ubiquitin conjugating system; Ubiquitin ligase Q13263 10155 19q13.43 human S473-p 452391 SGVKRSRsGEGEVSG activity, induced; molecular association, regulation; intracellular localization cell cycle regulation; carcinogenesis, induced; carcinogenesis, inhibited; transcription, induced; signaling pathway regulation; DNA repair, induced; chromatin organization, altered; cell growth, induced NFkB-p65(DISRUPTS); SUV39H1(INDUCES); HP1 alpha(DISRUPTS); MCM3(INDUCES); PCNA(INDUCES); CTIF(INDUCES); MCM6(INDUCES); TRIM24(DISRUPTS) DNA(DISRUPTS) 22205726; 22491012; 22715096; 23645696; 23740979; 24711418; 26158765; 28864417; 29955894; 30323812; 33783327; 34419074; 34518220; 34689152; 35533307 27 117 20 -GJA8 GJA8 Channel, misc.; Membrane protein, integral; Membrane protein, multi-pass P48165 2703 1q21.2 human S259-p 2574909 LHSIAVSsIQKAKGY protein stabilization; intracellular localization 35120923 1 2 0 -Irf1 IRF1 Transcription factor; Tumor suppressor P15314 16362 11 B1.3|11 32.0 cM mouse S185-p 1380568701 RDITPALsPCVVSSS protein degradation; molecular association, regulation; ubiquitination cell growth, inhibited; transcription, induced FBXW7(INDUCES) 30854564 1 0 0 de-stabilization of chromatin-associated IRF1; induced expression of TRAIL, OAS3, PSMA6, and TBC1D32; RNA-Pol-II elongation; anti-proliferative activity in cancer cells -RUFY1 RUFY1 Ubiquitin conjugating system Q96T51 80230 5q35.3 human Y389-p 451277 TKVELETyKQTRQGL intracellular localization 11877430 1 0 2 -G6PD G6PD iso3 Carbohydrate Metabolism - pentose phosphate pathway; Cell development/differentiation; EC 1.1.1.49; Other Amino Acids Metabolism - glutathione; Oxidoreductase P11413-3 2539 Xq28 human S210-p 15207801 FGRDLQSsDRLSNHI G6PD_N enzymatic activity, induced 20649491 1 0 0 -Ptpn11 SHP-2 EC 3.1.3.48; Motility/polarity/chemotaxis; PHOSPHATASE; Protein phosphatase, tyrosine (non-receptor) P41499 25622 12q16 rat Y542-p 448492 SKRKGHEyTNIKYSL molecular association, regulation; intracellular localization; enzymatic activity, induced; phosphorylation neural plasticity caveolin-1(INDUCES) 25672415; 28768764; 35439551 38 25 442 -Pparg PPAR-gamma iso2 DNA-binding; Nuclear receptor; Transcription factor P37238-2 19016 6 E3|6 53.41 cM mouse K77-sm 3617602 QEYQSAIkVEPASPP PPARgamma_N molecular association, regulation; activity, inhibited transcription, inhibited HDAC3(INDUCES); N-CoR1(INDUCES) 16127449; 23826177 15 0 0 -ERBB2 HER2 EC 2.7.10.1; KINASE; Kinase, protein; Membrane protein, integral; Oncoprotein; Protein kinase, TK; Protein kinase, tyrosine (receptor) P04626 2064 17q12 human Y1221-p 449744 SPAFDNLyYWDQDPP enzymatic activity, induced carcinogenesis, induced; apoptosis, inhibited; cell motility, altered; cell growth, altered 18332126; 19525980; 20498373; 35864174; 37324940 34 1 14 -Cryab CRYAB Chaperone; Heat shock protein P23928 25420 8q23 rat T170-gl 5281706 REEKPAVtAAPKK__ protein degradation; molecular association, regulation; intracellular localization; phosphorylation HSP27(INDUCES) 23543138; 8639509 4 4 0 -Ybx1 YB-1 RNA processing; RNA splicing; RNA-binding; Transcription factor P62960 22608 4|4 D2.1 mouse S100-p 455636 NPRKYLRsVGDGETV CSD protein degradation; molecular association, regulation; ubiquitination OTUB1(DISRUPTS) 35490780 23 33 2 -Il6st gp130 Membrane protein, integral; Receptor, cytokine Q00560 16195 13 D2.2|13 63.73 cM mouse Y904-p 448182 DEEIPKSyLPQTVRQ transcription, altered; signaling pathway regulation 36947594 3 4 16 regulates Src and MAPK/ERK signaling -Smurf2 SMURF2 EC 6.3.2.-; EC 6.3.2.19; Ligase; UBIQUITIN LIGASE; Ubiquitin conjugating system; Ubiquitin ligase A2A5Z6 66313 11|11 E1 mouse T249-p 27457334 MSRTHLHtPPDLPEG enzymatic activity, induced cell differentiation, inhibited; transcription, inhibited; signaling pathway regulation 35304894 2 2 0 inhibits Smad1/5/8-dependent signaling -Nrip1 RIP140 Nuclear receptor co-regulator; Transcription, coactivator/corepressor Q8CBD1 268903 16|16 C3.1 mouse R240-m1 2363402 EPLSCAArLQAVASM NRIP1_repr_1 transcription, induced 19216533 2 2 0 -AKAP12 AKAP12 Adaptor/scaffold Q02952 9590 6q25.1 human K531-ac 1883516301 GLKKLSGkKQKGKRG protein degradation; ubiquitination 36122629 1 1 0 deacetylation K531 by HDAC6 facilitates its ubiquitination and degradation -MALT1 MALT1 Adaptor/scaffold; Apoptosis; EC 3.4.22.-; Ligase; Nuclear export; Protease; UBIQUITIN LIGASE; Ubiquitin conjugating system Q9UDY8 10892 18q21.32 human K824-ub 2134710 DRLRISEk_______ protein degradation; molecular association, regulation IKKA(INDUCES) 17948050 1 0 0 activation of NF-kB pathway and IL-2 induction -NEDD4L NEDD4L EC 6.3.2.-; EC 6.3.2.19; Ligase; UBIQUITIN LIGASE; Ubiquitin conjugating system; Ubiquitin ligase Q96PU5 23327 18q21.31 human S428-p 487434 AEDGASGsATNSNNH activity, inhibited 17715136 1 0 0 Phosphorylation of S342 and S428 (more important site) inhibits Nedd4L which regulates ENaC activity. -TP53 p53 Activator; DNA-binding; Motility/polarity/chemotaxis; Nuclear receptor co-regulator; Transcription factor; Tumor suppressor P04637 7157 17p13.1 human T155-p 455908 DSTPPPGtRVRAMAI P53 protein degradation; molecular association, regulation; ubiquitination cell cycle regulation; carcinogenesis, induced; cell growth, induced; cell growth, inhibited; apoptosis, induced; transcription, induced MDM2(INDUCES); FBXO42(INDUCES) 11285227; 12628923; 16964247; 21127074; 33745968 5 0 1 -NUMA1 NuMA-1 Cell cycle regulation; Motility/polarity/chemotaxis Q14980 4926 11q13.4 human T2084-p 31033005 SPNTRSGtRRSPRIA cell growth, induced; apoptosis, inhibited 23097092 1 1 0 cell proliferation increased -PRMT3 PRMT3 C2H2-type zinc finger protein; EC 2.1.1.-; METHYLTRANSFERASE; Methyltransferase; Methyltransferase, protein arginine O60678 10196 11p15.1 human Y87-p 17489700 HKHGLEFyGYIKLIN molecular association, regulation; enzymatic activity, inhibited RPS2(INDUCES) 21059412 1 0 0 -CHAT CHAT iso3 ACETYLTRANSFERASE; Acetyltransferase; EC 2.3.1.6; Lipid Metabolism - glycerophospholipid P28329-3 1103 10q11.23 human S346-p 454035 LLKHVTQsSRKLIRA Carn_acyltransf enzymatic activity, induced 15381704 1 0 0 -SRARP C1orf64 Q8NEQ6 149563 1p36.13 human T152-p 125108504 VRSSTWGtVKDSLKA C1ORF64 molecular association, regulation 14-3-3 beta(INDUCES); 14-3-3 zeta(INDUCES) 28571002; 28915724 2 0 0 -PIP5K1C PIP5K1C Carbohydrate Metabolism - inositol phosphate; EC 2.7.1.68; Kinase, lipid; Motility/polarity/chemotaxis O60331 23396 19p13.3 human S555-p 1855423 RYRRRTQsSGQDGRP protein degradation; molecular association, regulation; intracellular localization cell motility, induced; cell adhesion, induced; cytoskeletal reorganization talin 1(DISRUPTS) 26149501; 27780861 2 15 22 localizing to focal adhesions, indispensable for breast cancer cell invasion; downregulates formations of stress fibers, promotes FA turnover rates -MDC1 MDC1 Cell cycle regulation Q14676 9656 6p21.33 human S376-p 477758 LQESQAGsDTDVEEG molecular association, regulation cell cycle regulation NBS1(INDUCES) 18678890 1 26 27 MDC1-NBS1 interaction regulates intra-S-phase checkpoint activation -GFI1 GFI1 C2H2-type zinc finger protein; Cell cycle regulation; Cell development/differentiation; Transcription factor Q99684 2672 1p22.1 human S98-p 1868711303 RPPSPSAsPASEKSM protein degradation; molecular association, regulation; ubiquitination carcinogenesis, altered; signaling pathway regulation FBXW7(INDUCES) 31289136 1 1 0 -CFTR CFTR Channel, chloride; EC 3.6.3.49; Hydrolase; Membrane protein, integral; Membrane protein, multi-pass; Transporter; Transporter, ABC family P13569 1080 7q31.2 human S795-p 449982 TASTRKVsLAPQANL CFTR_R activity, induced; molecular association, regulation; enzymatic activity, inhibited; protein conformation; phosphorylation 14-3-3 beta(INDUCES); CFTR(INDUCES) 14602047; 1716180; 26888287; 32102849; 36695813 10 7 0 primes phosphorylation at S813 -APC APC Motility/polarity/chemotaxis; Tumor suppressor P25054 324 5q22.2 human S2054-p 454101 MPKKKKPsRLKGDNE intracellular localization 11050185; 11689703 2 0 0 -ATF4 ATF-4 DNA-binding; Transcription factor P18848 468 22q13.1 human S245-p 451446 TRGSPNRsLPSPGVL activity, induced carcinogenesis, induced; cell growth, altered 15109498; 22052162 3 1 0 -Smad2 SMAD2 DNA-binding; Transcription factor Q62432 17126 18 E3|18 51.42 cM mouse S245-p 448794 NQSMDTGsPAELSPT protein stabilization; molecular association, regulation; enzymatic activity, induced apoptosis, induced; transcription, induced; signaling pathway regulation 29700281 12 0 0 increase MELK stability and activity; regulate ASK1/TGF-beta/p53 signaling pathways -Efnb3 EFNB3 Cell development/differentiation; Ligand, receptor tyrosine kinase; Membrane protein, integral G3V7D4-1 360546 10q24 rat S332-p 27722391 VQDGPPQsPPNIYYK protein stabilization; molecular association, regulation; intracellular localization PSD-95(DISRUPTS) 26479588 1 1 0 reduces synaptic localization -Acadl ACADL EC 1.3.8.8; Lipid Metabolism - fatty acid; Mitochondrial; Oxidoreductase P51174 11363 1 C3|1 33.64 cM mouse K318-ac 1204118 RNYVKQRkAFGKTVA Acyl-CoA_dh_1 protein conformation; enzymatic activity, induced 24121500 1 2 1 -SIAH2 SIAH2 EC 6.3.2.-; EC 6.3.2.19; Ligase; Transcription, coactivator/corepressor; UBIQUITIN LIGASE; Ubiquitin conjugating system; Ubiquitin ligase O43255 6478 3q25.1 human S16-p 26371003 PSANKPCsKQPPPQP protein degradation; intracellular localization; enzymatic activity, induced cytoskeletal reorganization 22878263; 23044042 2 2 0 -SWAP70 SWAP-70 GEF; GEF, Rac/Rho Q9UH65 23075 11p15.4 human Y426-p 23149858 VRELEDMyLKLQEAL molecular association, regulation; intracellular localization cytoskeletal reorganization ACTN1 iso2(DISRUPTS); SWAP-70(DISRUPTS) 31932501 1 0 1 -FSCN1 fascin Actin-binding; Cytoskeletal; Motility/polarity/chemotaxis Q16658 6624 7p22.1 human K399-ub 8104831 HGFIGCRkVTGTLDA Fascin cytoskeletal reorganization 27879315 1 4 5 fascin bundling activity -BCL10 Bcl-10 Apoptosis; Transcription, coactivator/corepressor; Tumor suppressor O95999 8915 1p22.3 human S141-p 4786673 SRSNSDEsNFSEKLR activity, induced 21199863 1 2 2 -PTK2B Pyk2 EC 2.7.10.2; KINASE; Kinase, protein; Nuclear receptor co-regulator; Protein kinase, TK; Protein kinase, tyrosine (non-receptor) Q14289 2185 8p21.2 human Y402-p 447955 CSIESDIyAEIPDET protein degradation; molecular association, regulation; ubiquitination; intracellular localization; phosphorylation; enzymatic activity, induced cell cycle regulation; cell motility, altered; signaling pathway regulation RASA1(INDUCES); SOCS2(INDUCES); Src(INDUCES); HER2(INDUCES) 10713673; 10867021; 15070849; 15105428; 15778498; 16760434; 19919693; 20543098; 22802128; 25090023; 29133485; 32792487 86 2 22 activation of Src, Pyk2-mediated phosphorylation of Nox5 -ERBB3 HER3 EC 2.7.10.1; KINASE; Kinase, protein; Membrane protein, integral; Oncoprotein; Protein kinase, TK; Protein kinase, tyrosine (receptor) P21860 2065 12q13.2 human Y1054-p 449859 LLSPSSGyMPMNQGN molecular association, regulation carcinogenesis, induced; cell motility, induced PIK3R2(INDUCES); PIK3R1(INDUCES) 16729043; 21725367 3 2 20 chemotaxis and invasion -Dzip1 DZIP1 C2H2-type zinc finger protein Q8BMD2 66573 14|14 E4 mouse S664-p 13907508 STKTPPFsSEEEPDE transcription, induced; signaling pathway regulation 21878643 1 0 0 involved in Gli1 nad Gli3 turnover pathway -TRPC3 TRPC3 Channel, cation; Membrane protein, integral; Membrane protein, multi-pass Q13507 7222 4q27 human S336-p 458336 KNDYRKLsMQCKDFV activity, inhibited 14983059; 16331690 2 0 0 -Styk1 STYK1 EC 2.7.10.2; KINASE; Kinase, protein; Membrane protein, integral; Oncoprotein; Protein kinase, TK; Protein kinase, tyrosine (non-receptor); Protein kinase, tyrosine (receptor) Q6J9G1 243659 6|6 F3 mouse Y363-p 458345 SSCSHAMyNIMKCCW PK_Tyr_Ser-Thr apoptosis, inhibited; cell growth, altered 16322230 1 0 0 mutation of this site promotes cellular apoptosis -Myo3a MYO3A Actin-binding; EC 2.7.11.1; KINASE; Kinase, protein; Motor; Protein kinase, STE; Protein kinase, Ser/Thr (non-receptor) Q8K3H5 667663 2|2 A3 mouse S313-p 36841904 DIHQCLGsTEKARHE enzymatic activity, induced 21895655 1 1 0 -Crem CREM DNA-binding; Transcription factor P27699 12916 18|18 A1 mouse S156-p 450064 PKIEEEKsEEEGTPP activity, inhibited transcription, altered 8114763 2 0 0 -KIR2DL1 KIR2DL1 Membrane protein, integral; Receptor, misc. P43626 3802 19q13.42 human Y302-p 462345 QDPQEVTyTQLNHCV molecular association, regulation signaling pathway regulation supervillin(INDUCES) 21070852 1 2 1 supervillin is required for KIR2DL1-mediated inhibition of Vav1 and Erk phosphorylation -ETV5 ERM DNA-binding; Transcription factor P41161 2119 3q27.2 human K350-sm 2887211 ERLEGKVkQEPTMYR ETS_PEA3_N transcription, inhibited 15857832; 18243147 2 1 0 -BIRC5 Survivin Apoptosis O15392 332 17q25.3 human K91-ub 40439804 CAFLSVKkQFEELTL protein degradation 25778398 1 2 0 impairs mitochondrial function -ESR2 ER-beta DNA-binding; Nuclear receptor Q92731 2100 14q23.2-q23.3 human S105-p 447914 LYAEPQKsPWCEARS ERbeta_N activity, induced; intracellular localization 15862947; 20696772 5 1 0 expressed in nucleus and as nuclear speckles -PKN2 PKN2 EC 2.7.11.13; KINASE; Kinase, protein; Protein kinase, AGC; Protein kinase, Ser/Thr (non-receptor) Q16513 5586 1p22.2 human S815-p 4754738 MGYGDRTsTFCGTPE Pkinase enzymatic activity, induced 19723632 1 3 37 -Was WASP Adaptor/scaffold; Motility/polarity/chemotaxis P70315 22376 X A1.1|X 3.65 cM mouse S502-p 449295 RSRVIHSsDEGEDQT activity, induced cytoskeletal reorganization 24223520 2 11 0 -Tfeb TFEB DNA-binding; Transcription factor Q9R210 21425 17 C|17 23.99 cM mouse S400-p 1880515602 LDFSHGLsFGGGGDE intracellular localization cell differentiation, induced; transcription, induced 36507874 1 0 0 -Mybpc3 MYBPC3 Myosin-binding P56741 295929 3q24 rat S288-p 471080 AGTGRRTsDSHEDAG molecular association, regulation cytoskeletal reorganization TNNI3(DISRUPTS) 35288601; 36470422 35 8 28 -Rptor Raptor Adaptor/scaffold Q8K4Q0 74370 11|11 E2 mouse S877-p 3205938 HMHQVGGsPPASSTS enzymatic activity, inhibited 31530866 8 54 0 suppresses mTORC1 activity -E2F1 E2F1 DNA-binding; Transcription factor Q01094 1869 20q11.22 human S337-p 447869 IVSPPPSsPPSSLTT molecular association, regulation; intracellular localization; protein conformation cell cycle regulation; transcription, induced; transcription, altered; cell growth, altered PRB1(INDUCES); Rb(DISRUPTS); E4(INDUCES) DNA(INDUCES) 20616879; 26724859; 27935805; 29264472; 35678423; 8087847 9 1 0 -CLDN6 Claudin-6 Cell adhesion; Membrane protein, integral; Membrane protein, multi-pass P56747 9074 16p13.3 human Y200-p 7792487 PSHYMARySTSAPAI cell adhesion, altered; signaling pathway regulation 31740618 1 2 17 -PPP1R3F PPP1R3F Membrane protein, integral; Protein phosphatase, regulatory subunit Q6ZSY5 89801 Xp11.23 human S401-p 22650303 EGDVPRSsPPVAFTE signaling pathway regulation 21668450 0 1 0 regulation of glycogen synthesis via R3F-PP1 signaling in astrocytoma cells -Vamp4 VAMP4 Membrane protein, integral; Vesicle O70480 53330 1 H2.1|1 70.29 cM mouse S30-p 454285 RNLLEDDsDEEEDFF molecular association, regulation; intracellular localization PACS-1(INDUCES) 14608369 1 75 10 -ATF7 ATF7 C2H2-type zinc finger protein; DNA-binding; Transcription factor P17544 11016 12q13.13 human K107-sm 4617200 STPDIKIkEEEPVEV intracellular localization transcription, inhibited 17264123; 18950637 2 0 0 -Trpv2 TRPV2 Channel, cation; Membrane protein, integral; Membrane protein, multi-pass Q9WUD2 29465 10q23 rat S760-p 7103644 LPLQVLQsP______ cell growth, induced 26416880 1 6 0 neurite outgrowth -Aatf AATF Nucleolus; RNA-binding; Transcription factor Q9JKX4 56321 11|11 C mouse S316-p 1868281680 LEMEDYPsFMAKRFA AATF-Che1 acetylation chromatin organization, altered; cell growth, induced; transcription, induced H3(INDUCES) 34266450 1 2 0 induces histone acetylation -RHO Rhodopsin GPCR, family 1; Membrane protein, integral; Membrane protein, multi-pass; Receptor, GPCR P02699 509933 cow S338-p 448679 DEASTTVsKTETSQV molecular association, regulation; protein conformation SAG(INDUCES) 15041682 8 7 0 Computational and in vitro data. S343 may be a weaker interaction. -GATA2 GATA2 Transcription factor P23769 2624 3q21.3 human T176-p 40245500 HLFGFPPtPPKEVSP protein degradation; molecular association, regulation FBXW7(INDUCES) 25670854 1 1 0 -Hk2 HK2 Carbohydrate Metabolism - amino sugar and nucleotide sugar; Carbohydrate Metabolism - fructose and mannose; Carbohydrate Metabolism - galactose; Carbohydrate Metabolism - glycolysis and gluconeogenesis; Carbohydrate Metabolism - starch and sucrose; EC 2.7.1.1; Kinase, other; Mitochondrial O08528 15277 6 C3|6 35.94 cM mouse T473-p 28704601 QHRARQKtLESLKLS Hexokinase_1 intracellular localization; enzymatic activity, induced carcinogenesis, induced; cell motility, induced; chromatin organization, altered; apoptosis, inhibited 23836898; 23852728; 30877036 6 0 0 mitochondria-associated ER membrane integrity; increase lactic acid production; regulate NF-kB/HIF1a/MMP2/MMP9 expressions; protects against oxidative stress increasing cell viability -Pde3a PDE3A EC 3.1.4.17; Membrane protein, integral; Membrane protein, multi-pass; Nucleotide Metabolism - purine; Phosphodiesterase Q9Z0X4 54611 6|6 G2 mouse S292-p 471417 KRRRRSSsVVAGEMS enzymatic activity, induced 17124499 1 2 10 activated during oocytes maturation in mouse treated with hCG ; required for insulin-dependent Xenopus oocyte maturation -PSIP1 LEDGF Motility/polarity/chemotaxis; Transcription, coactivator/corepressor O75475 11168 9p22.3 human S206-p 7231784 MVKQPCPsESDIITE phosphorylation 19864417 1 12 0 stimulates phosphorylation of MCM2 at S53 -PIKFYVE PIKFYVE Carbohydrate Metabolism - inositol phosphate; EC 2.7.1.150; KINASE; Kinase, lipid; Motility/polarity/chemotaxis; Protein kinase, Ser/Thr (non-receptor) Q9Y2I7 200576 2q34 human S318-p 3216759 LSLDRSGsPMVPSYE activity, induced; enzymatic activity, induced carcinogenesis, inhibited; cell motility, inhibited; signaling pathway regulation 19232516; 23188060; 23757022; 30445978 4 3 7 Increased Kir2.1 mediated current; induce activation of chloride channel CLCN2; dephosphorylation of PIKFYVE leads to activated EGFR signaling; induces EGFR degradation and regulates EGFR phosphorylation -AR AR DNA-binding; Nuclear receptor; Transcription factor P10275 367 Xq12 human T282-p 15605002 VPPAVRPtPCAPLAE Androgen_recep activity, induced; molecular association, regulation transcription, altered; cell growth, altered DNA(NOT_REPORTED) 20713353 1 0 0 -KEAP1 KEAP1 Endoplasmic reticulum; Motility/polarity/chemotaxis; Transcription regulation; UBIQUITIN LIGASE; Ubiquitin conjugating system Q14145 9817 19p13.2 human K312-ac 1883300103 FEELTLHkPTQVMPC protein stabilization; molecular association, regulation transcription, inhibited Tau(INDUCES) 35917404 1 0 0 hP301S mutant Tau, decreases the transcription of synaptic genes in the presence of P301S mutant, synapse loss and cognitive dysfunction -SQSTM1 SQSTM1 Autophagy; Nuclear receptor co-regulator; Ubiquitin conjugating system Q13501 8878 5q35.3 human K295-ac 1881279900 SCCSDPSkPGGNVEG protein degradation carcinogenesis, inhibited 33854041 1 1 0 Sirt1 stabilizes SQSTM1 by inhibiting its acetylation, suppressing its ubiquitylation. -Flt3 FLT3 EC 2.7.10.1; KINASE; Kinase, protein; Membrane protein, integral; Oncoprotein; Protein kinase, TK; Protein kinase, tyrosine (receptor) Q00342 14255 5 86.88 cM|5 G3 mouse Y892-p 456469 FSLGVNPyPGIPVDA PK_Tyr_Ser-Thr protein stabilization; enzymatic activity, induced 16091740 1 0 0 -Tagln TAGLN Actin-binding; Motility/polarity/chemotaxis; Nuclear receptor co-regulator P31232 25123 8q22 rat K21-ub 49199201 VQSKIEKkYDEELEE molecular association, regulation G6PD(INDUCES) 26291555 1 0 0 -ERBB2 HER2 EC 2.7.10.1; KINASE; Kinase, protein; Membrane protein, integral; Oncoprotein; Protein kinase, TK; Protein kinase, tyrosine (receptor) P04626 2064 17q12 human Y1139-p 448678 TCSPQPEyVNQPDVR molecular association, regulation cell motility, altered; cell adhesion, altered; transcription, induced; signaling pathway regulation; cell growth, altered GRB2(INDUCES); Src(INDUCES); GRB7(INDUCES); JAK2(NOT_REPORTED) 11238891; 11940572; 12551896; 16729043; 18332126; 9516479 11 5 46 -HDAC2 HDAC2 DEACETYLASE; Deacetylase; EC 3.5.1.98; Nuclear receptor co-regulator; Transcription, coactivator/corepressor Q92769 3066 6q21 human Y222-p 464957 IGAGKGKyYAVNFPM Hist_deacetyl protein stabilization; ubiquitination transcription, inhibited 25219501 1 0 2 inhibits polyubiquitination -MRE11 MRE11A Cell cycle regulation; DNA repair, damage; DNA-binding; Deoxyribonuclease P49959 4361 11q21 human R594-m2 62978407 RGGSQRGrADTGLET DNA repair, altered 15741314 0 1 0 -CHEK2 Chk2 EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, CAMK; Protein kinase, Ser/Thr (non-receptor); Tumor suppressor O96017 11200 22q12.1 human T26-p 447547 SQPHGSVtQSQGSSS phosphorylation; enzymatic activity, induced 12024051 3 1 0 -MYLK smMLCK EC 2.7.11.18; KINASE; Kinase, protein; Protein kinase, CAMK; Protein kinase, Ser/Thr (non-receptor) Q15746 4638 3q21.1 human Y471-p 451415 YEDAGSHyLCLLKAR I-set molecular association, regulation; enzymatic activity, induced Cortactin(INDUCES) 11113114; 12408982 2 1 5 -Trim28 TIF1B EC 6.3.2.-; KINASE; Kinase, protein; Ligase; Nuclear receptor co-regulator; Protein kinase, atypical; SUMO LIGASE; SUMO ligase; Transcription, coactivator/corepressor; UBIQUITIN LIGASE; Ubiquitin conjugating system; Ubiquitin ligase Q62318 21849 7|7 A1 mouse K779-sm 2798309 FNKLTEDkADVQSII transcription, inhibited 17298944 6 8 0 -ARAF ARAF EC 2.7.11.1; KINASE; Kinase, protein; Oncoprotein; Protein kinase, Ser/Thr (non-receptor); Protein kinase, TKL P10398 369 Xp11.3 human Y301-p 455521 LGYRDSGyYWEVPPS activity, induced 9020159 1 2 9 -Itpr1 IP3R1 Channel, calcium; Channel, ligand-gated; Membrane protein, integral; Membrane protein, multi-pass P11881 16438 6 E1|6 49.74 cM mouse S1755-p 450682 RPSGRREsLTSFGNG activity, induced; phosphorylation transcription, induced; signaling pathway regulation 17257671; 22495310; 34905386 13 24 15 induces phosphorylation of CAMK2 and downstream targets; induce calcineurin activation, CRTC2 dephosphorylation and activation IP3R1 and gluconeogenesis.; Ca(2+) mobilization -JUND JunD Motility/polarity/chemotaxis; Transcription factor P17535 3727 19p13.11 human T71-p 23117102 PAAAPPPtPLRADGA Jun molecular association, regulation carcinogenesis, induced; transcription, induced PPP1R13B(DISRUPTS) 36261000 1 1 1 -ROBO1 ROBO1 Cell adhesion; Membrane protein, integral; Motility/polarity/chemotaxis Q9Y6N7 6091 3p12.3 human Y1073-p 465118 PSGQPTPyATTQLIQ activity, inhibited 10892742 1 3 5 -Plcg2 PLCG2 Carbohydrate Metabolism - inositol phosphate; EC 3.1.4.11; Motility/polarity/chemotaxis; Phospholipase P24135 29337 19q12 rat Y759-p 447941 LYDVSRMyVDPSEIN enzymatic activity, induced 11507089 21 13 227 -TEAD4 TEAD4 DNA-binding; Transcription factor Q15561 7004 12p13.33 human S322-p 451164 GVSSQYEsPENMIIT YBD activity, induced 10764782 1 0 0 Mutation of S315 to alanine reduced alpha1-adrenergic activation of TEF-3. -JUN Jun Oncoprotein; Transcription factor P05412 3725 1p32.1 human T89-p 17737602 QSSNGHItTTPTPTQ Jun carcinogenesis, altered; cell growth, altered 21177766 1 0 0 -CREB3L3 CREB3L3 Membrane protein, integral; Transcription factor Q68CJ9 84699 19p13.3 human K294-ac 15293936 RKVLHLEkQNLSLLE bZIP_1 activity, induced; molecular association, regulation; protein processing transcription, induced PPAR-alpha(INDUCES) 26438600; 28461393 3 0 1 hepatic glycogenolysis and gluconeogenesis; PCK1 and PYGL transcription. Maintains glucose homeostasis -NDC80 HEC1 Cell cycle regulation O14777 10403 18p11.32 human S69-p 474513 SGHGSRNsQLGIFSS Ndc80_HEC cell cycle regulation; cytoskeletal reorganization 17129782; 29187526; 35878017; 36897279 6 17 17 -ESR1 ER-alpha DNA-binding; Nuclear receptor; Transcription factor P03372 2099 6q25.1-q25.2 human R260-m2 34490425 GGIRKDRrGGRMLKH molecular association, regulation cell cycle regulation Src(INDUCES); PIK3R1(INDUCES) 18657504 1 0 0 occurring in the cytoplasm of normal and tumor epithelial breast cells in humans -RUNX2 AML3 DNA-binding; Transcription factor Q13950 860 6p21.1 human S28-p 3053615 PSTSRRFsPPSSSLQ transcription, altered 19264160 8 14 1 -Hnrnpa1 hnRNP A1 Nuclear export; RNA splicing; RNA-binding; Spliceosome P04256 29578 7q36 rat S192-p 456539 EMASASSsQRGRSGS activity, inhibited 7727389 2 0 0 -CDH1 CDH1 Cell adhesion; Membrane protein, integral; Motility/polarity/chemotaxis; UBIQUITIN LIGASE; Ubiquitin ligase P12830 999 16q22.1 human S847-p 465568 SEAASLSsLNSSESD CADH_Y-type_LIR protein stabilization carcinogenesis, altered; cell motility, inhibited 35115926 4 0 0 -Yy1 YY1 C2H2-type zinc finger protein; Cell development/differentiation; Transcription factor Q00899 22632 12 F1|12 59.58 cM mouse S184-p 476106 GKKSGKKsYLGGGAG molecular association, regulation RNA(DISRUPTS) 28834756 2 3 1 -OCLN occludin Cell adhesion; Membrane protein, integral; Membrane protein, multi-pass; Motility/polarity/chemotaxis Q16625 100506658 5q13.2 human T403-p 471471 DHYETDYtTGGESCD intracellular localization 19114660 2 2 4 -Pak5 PAK5 EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, STE; Protein kinase, Ser/Thr (non-receptor) Q8C015 241656 2|2 F3 mouse S602-p 447773 KEVPKRKsLVGTPYW Pkinase cell growth, induced 34087103 3 13 42 -PANX1 PANX1 Cell adhesion; Membrane protein, integral; Membrane protein, multi-pass Q96RD7 24145 11q21 human Y150-p 4113671 MEELDKVyNRAIKAA Innexin intracellular localization 33405952 1 1 1 -Irs1 IRS1 Adaptor/scaffold; Motility/polarity/chemotaxis P35570 25467 9q34 rat S307-p 447558 TESITATsPASMVGG molecular association, regulation; phosphorylation signaling pathway regulation INSR(DISRUPTS) 11160134; 11606564; 25978724 77 14 0 -MDM2 MDM2 EC 6.3.2.-; EC 6.3.2.19; Inhibitor; Ligase; NEDDYLATION LIGASE; Neddylation Ligase; Nucleolus; Oncoprotein; UBIQUITIN LIGASE; Ubiquitin conjugating system; Ubiquitin ligase Q00987 4193 12q15 human Y276-p 465467 SDEDDEVyQVTVYQA molecular association, regulation; intracellular localization p14ARF(INDUCES) 16702947 1 1 0 contributes to Hdm2-mediated turnover of p53 -IRS1 IRS1 Adaptor/scaffold; Motility/polarity/chemotaxis P35568 3667 2q36.3 human S629-p 478346 VPSGRKGsGDYMPMS molecular association, regulation PIK3R1(INDUCES) 17640984 2 15 38 -PRKCE PKCE EC 2.7.11.13; KINASE; Kinase, protein; Protein kinase, AGC; Protein kinase, Ser/Thr (non-receptor) Q02156 5581 2p21 human S368-p 2085101 NNIRKALsFDNRGEE molecular association, regulation cell cycle regulation; transcription, altered 14-3-3 beta(INDUCES) 18458086; 18604201 3 17 0 -Stat1 STAT1 DNA-binding; Transcription factor Q9QXK0 25124 9q22 rat S727-p 447753 TENLLPMsPEEFDEM STAT1_TAZ2bind activity, induced apoptosis, induced; apoptosis, inhibited; transcription, altered 11309387; 14984365 118 32 90 -ATF2 ATF-2 ACETYLTRANSFERASE; C2H2-type zinc finger protein; EC 2.3.1.48; Transcription factor P15336 1386 2q31.1 human T52-p 23305000 HKHKHEMtLKFGPAR intracellular localization carcinogenesis, induced; cell motility, induced; cell growth, induced; apoptosis, inhibited; transcription, induced; transcription, inhibited; cell adhesion, inhibited 22304920; 26645581 2 0 1 T52 phosphorylation negatively regulates ATF-2 mitochondrial localization and basal transcriptional activity of ATF-2.; decreased FUK expression, decreased cellular protein fucosylation -HMGB1 HMGB1 DNA repair, damage; Nuclear receptor co-regulator P09429 3146 13q12.3 human K82-ac 460592 MKTYIPPkGETKKKF chromatin organization, altered 15005629 5 4 0 -FOSL1 FRA1 DNA-binding; Transcription factor P15407 8061 11q13.1 human T230-p 27259000 TPSLTPFtPSLVFTY protein stabilization 22286759 1 0 0 -Scimp UNQ5783 Membrane protein, integral Q3UU41 327957 11|11 B3 mouse Y96-p 464681 PRQPSAWySSVKKVR SCIMP molecular association, regulation transcription, induced GRB2(INDUCES); TLR4(INDUCES); CSK(INDUCES); Syk(INDUCES); TLR2(INDUCES); BLNK(INDUCES); TLR3(INDUCES); TLR1(INDUCES) 34496234; 35337798 2 0 9 -FMR1 FMR1 iso3 Nucleolus; RNA-binding; Translation Q06787-3 2332 Xq27.3 human S499-p 14323700 SDHRDELsDWSLAPT FXMRP1_C_core molecular association, regulation; intracellular localization TDP-43(DISRUPTS) 30630951 4 1 0 -MARK3 MARK3 iso3 EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, CAMK; Protein kinase, Ser/Thr (non-receptor) P27448-3 4140 14q32.32-q32.33 human S96-p 3597304 KTQLNPTsLQKLFRE Pkinase enzymatic activity, inhibited 15319445 1 0 0 -Ephb2 EphB2 EC 2.7.10.1; KINASE; Kinase, protein; Membrane protein, integral; Protein kinase, TK; Protein kinase, tyrosine (receptor); Tumor suppressor P54763 13844 4 D3|4 69.0 cM mouse Y596-p 448326 MTPGMKIyIDPFTYE EphA2_TM molecular association, regulation; enzymatic activity, induced cytoskeletal reorganization; cell adhesion, altered NMDAR1(INDUCES); RASA1(INDUCES); Src iso1(INDUCES) 10644995; 10848605; 11136979; 16977320 6 18 117 in vitro -Pfn1 profilin 1 Actin-binding; Cytoskeletal; Motility/polarity/chemotaxis P62962 18643 11 B3|11 43.21 cM mouse Y129-p 450514 GLINKKCyEMASHLR Profilin activity, induced cytoskeletal reorganization 28743718 4 25 658 higher activity of profilin-1 in Twf2a-/- platelets -Nf2 Merlin Cytoskeletal; Motility/polarity/chemotaxis; Tumor suppressor P46662 18016 11 A1|11 3.0 cM mouse S10-p 1720901 GAIASRMsFSSLKRK protein degradation; protein stabilization cytoskeletal reorganization 33414453 5 10 0 induces MDM2 stabilization and PSD95 degradation -PARP1 PARP1 DNA repair, damage; EC 2.4.2.30; Nuclear envelope; Nuclear receptor co-regulator; Nucleolus; Transferase P09874 142 1q42.12 human K486-sm 9859928 SPWGAEVkAEPVEVV ADP-ribosylation; protein degradation; molecular association, regulation; acetylation; ubiquitination transcription, induced; transcription, inhibited p300(DISRUPTS); RNF4(INDUCES) 19622798; 19779455; 20228053 3 6 0 -ILK ILK EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, Ser/Thr (non-receptor); Protein kinase, TKL Q13418 3611 11p15.4 human T181-p 6191018 RTRPRNGtLNKHSGI signaling pathway regulation 22521536 1 16 18 PKCA-ILK signaling pathway for growth cone collapse, RGC axon guidance, repulsive axon turning induced by Shh -GPI G6PI Apoptosis; Carbohydrate Metabolism - amino sugar and nucleotide sugar; Carbohydrate Metabolism - glycolysis and gluconeogenesis; Carbohydrate Metabolism - pentose phosphate pathway; Carbohydrate Metabolism - starch and sucrose; Cytokine; EC 5.3.1.9; Isomerase P06744 2821 19q13.11 human S185-p 455279 GPRVWYVsNIDGTHI PGI molecular association, regulation; enzymatic activity, inhibited cell growth, altered G6PI(INDUCES) 15637053 2 0 0 -Tuba1a TUBA1A Cytoskeletal; Motility/polarity/chemotaxis P68369 22142 15 F1|15 55.29 cM mouse K40-ac 460619 DGQMPSDkTIGGGDD Tubulin protein stabilization; acetylation; intracellular localization cell cycle regulation; autophagy, induced; cell motility, induced; cell motility, inhibited; cytoskeletal reorganization 22972992; 31018989; 31498540; 32697819; 32885602; 33195286; 35486479 71 7 11 knockdown of RASSF1A impairs spindle organization and chromosome alignment -FLNA FLNA Actin-binding; Motility/polarity/chemotaxis; Nuclear receptor co-regulator P21333 2316 Xq28 human S1459-p 452266 KCSGPGLsPGMVRAN Filamin molecular association, regulation cell motility, induced; cell motility, altered; cytoskeletal reorganization CCND1(DISRUPTS) 20179208; 25445790 2 71 16 cell separation following mitosis, AAA mutant has defects in cell motility -RNF20 RNF20 EC 6.3.2.-; EC 6.3.2.19; Ligase; UBIQUITIN LIGASE; Ubiquitin conjugating system; Ubiquitin ligase Q5VTR2 56254 9q31.1 human S172-p 18710200 SSSEEMEsQLQERVE ubiquitination DNA repair, induced 21362549 1 0 0 induces H2B-K125 ubiquitylation -Scn2a SCN2A Channel, sodium; Membrane protein, integral; Membrane protein, multi-pass P04775 24766 3q21 rat Y730-p 1152200 QKCPPCWyKFANMCL activity, inhibited 17959797 1 0 0 -GRB7 GRB7 Adaptor/scaffold; Motility/polarity/chemotaxis Q14451 2886 17q12 human Y188-p 7965100 FRKNFAKyELFKSSP phosphorylation cell cycle regulation; cell motility, altered 19473962 1 0 1 double mutation Grb7 Y188, 338F inhibits phosphorylation of FAK Y397 (Y428 in mouse), Y861 (Y899 in mouse) and PXN Y118; involed in tumorigenesis process -APP APP Apoptosis; Cell surface; Membrane protein, integral; Receptor, misc.; Transcription factor P05067 351 21q21.3 human K763-ne 12124801 GYENPTYkFFEQMQN APP_amyloid transcription, inhibited Fe65(DISRUPTS) 18096514 1 0 0 -DAPK1 DAPK1 Apoptosis; Autophagy; EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, CAMK; Protein kinase, Ser/Thr (non-receptor) P53355 1612 9q21.33 human S734-p 454887 NSSRFPPsPLASKPT enzymatic activity, induced apoptosis, altered; apoptosis, induced; cell adhesion, inhibited 15616583; 26769850 2 0 7 anoikis function of DAPK -MCM2 MCM2 DNA-binding; EC 3.6.4.12 P49736 4171 3q21.3 human S53-p 473058 LPPFEDEsEGLLGTE MCM2_N molecular association, regulation; enzymatic activity, induced cell cycle regulation; carcinogenesis, induced; chromatin organization, altered; apoptosis, inhibited; cell growth, altered DNA(INDUCES) 16446360; 17062569; 25412417; 25843623; 26921250; 28273463; 31578521 16 9 16 loss of CDC7 induce senescence in liver cancer cells -Erbb2 HER2 EC 2.7.10.1; KINASE; Kinase, protein; Membrane protein, integral; Oncoprotein; Protein kinase, TK; Protein kinase, tyrosine (receptor) P06494 24337 10q31 rat Y1141-p 448678 ACSPQPEyVNQSEVQ molecular association, regulation GRB2(INDUCES) 11500516 11 5 46 This site can mediate transforming signals. -Tuba1a TUBA1A Cytoskeletal; Motility/polarity/chemotaxis P68370 64158 7q36 rat K40-ac 460619 DGQMPSDkTIGGGDD Tubulin acetylation; protein stabilization; intracellular localization 34548475; 35486479 71 7 11 K40 acetylation decreases GLUT4 vesicles translocation to the plasma membrane; K40 acetylation level affects glucose transport -Prkaa1 AMPKA1 Autophagy; EC 2.7.11.1; EC 2.7.11.26; EC 2.7.11.27; EC 2.7.11.31; KINASE; Kinase, protein; Protein kinase, CAMK; Protein kinase, Ser/Thr (non-receptor) Q5EG47 105787 15|15 A1 mouse S508-p 4274314 RSCQRSDsDAEAQGK enzymatic activity, inhibited; phosphorylation 24928508 2 11 17 induces phosphorylation at S496 and inhibits phosphorylation at T183 further enhancing glucose production -TGFBR1 TGFBR1 EC 2.7.11.30; KINASE; Kinase, protein; Membrane protein, integral; Protein kinase, Ser/Thr (receptor); Protein kinase, TKL; Receptor, misc. P36897 7046 9q22.33 human T204-p 4325703 VQRTIARtIVLQESI activity, induced; phosphorylation; enzymatic activity, induced cell growth, induced; transcription, induced 18625725; 29467918; 33051597; 7774578 4 0 0 Induce transcription of SBE4; Induce phosphorylation of SMAD2/3; constitutively active mutant T204D -MYH10 MYH10 Motility/polarity/chemotaxis; Motor P35580 4628 17p13.1 human S1975-p 465603 NETQPPQsE______ cytoskeletal reorganization 30087119 2 21 0 downregulates filament assembly -HSPA1A HSP70 Chaperone; Heat shock protein; Motility/polarity/chemotaxis P0DMV8 3303 6p21.33 human T66-p 31882985 VALNPQNtVFDAKRL HSP70 intracellular localization; protein conformation cell cycle regulation 30108182 2 4 0 -CD5 CD5 Cell surface; Membrane protein, integral P06127 921 11q12.2 human T436-p 450130 FHRNHTAtVRSHAEN activity, induced; receptor internalization, altered 11123317 1 0 44 -ITGAM ITGAM iso100 Cell adhesion; Membrane protein, integral; Motility/polarity/chemotaxis P11215_VAR_P1146S 3684 16p11.2 human S1146-p 60885603 DMMSEGGsPGAEPQ_ molecular association, regulation 27974454 1 0 0 PS1146 substitution generates a binding site for 14-3-3-zeta, but does not require S1146 phosphorylation. -H2AC11 H2A.1 DNA-binding P0C0S8 8329 6p22.1 human K118-ub 3945247 IQAVLLPkKTESHHK Histone_H2A_C methylation; enzymatic activity, inhibited cell cycle regulation; carcinogenesis, induced; carcinogenesis, inhibited; cell growth, inhibited; DNA repair, induced; cell growth, induced; chromatin organization, altered; transcription, inhibited 20543557; 23238014; 24019522; 24292684; 25578731; 32427989 12 14 157 Overexpressed H2A rescuing DNA replication in Mdm4-depleted WT cells, but not in K118,119R mutant cells -Gata4 GATA4 Motility/polarity/chemotaxis; Transcription factor Q08369 14463 14 D1|14 33.24 cM mouse K366-sm 3982503 SEEMRPIkTEPGLSS intracellular localization cell differentiation, altered; transcription, induced 15337742 1 0 0 -ATP7A ATP7A Apoptosis; Cell development/differentiation; Chaperone; EC 3.6.3.54; Hydrolase; Membrane protein, integral; Membrane protein, multi-pass; Transporter; Transporter, ion channel; Vesicle Q04656 538 Xq21.1 human S339-p 9768104 RKAIEAVsPGLYRVS HMA protein conformation 21258844 2 7 0 S339 alters the dynamics of domain by increasing the flexibility whereas T327 decreasing the flexibility in Cu bound MBD3 -AKT1 Akt1 EC 2.7.11.1; KINASE; Kinase, protein; Oncoprotein; Protein kinase, AGC; Protein kinase, Ser/Thr (non-receptor) P31749 207 14q32.33 human K14-ub 12723502 VKEGWLHkRGEYIKT PH ubiquitination; intracellular localization; phosphorylation; enzymatic activity, induced 19713527; 31182807 2 3 0 promotes Akt membrane recruitment and phosphorylation, resulting in activation; IL-15-stimulated phosphorylation as well as in ubiquitination with K63ub as an acceptor for polyubiquitin chain formation and AKT activation. -HRAS HRas G protein; G protein, monomeric; G protein, monomeric, Ras; Motility/polarity/chemotaxis; Oncoprotein P01112 3265 11p15.5 human Y32-p 15228776 QNHFVDEyDPTIEDS Ras activity, inhibited carcinogenesis, inhibited; signaling pathway regulation 33413561 3 4 8 inhibits MAPK signaling -Trarg1 TUSC5 Membrane protein, integral; Membrane protein, multi-pass Q8C838 237858 11|11 B5 mouse S80-p 3842521 GSPSRVSsRRASSVI intracellular localization 35594055 1 4 0 regulates GLUT4 translocation -Rbck1 RBCK1 EC 6.3.2.-; Ligase; UBIQUITIN LIGASE; Ubiquitin conjugating system; Ubiquitin ligase Q62921 rat T207-p 2103605 CTFINKPtRPGCEMC protein stabilization 18303026 2 0 0 inhibits self-ubiquitination of RBCK1 in vitro -Sirpa SHPS1 Cell adhesion; Cell surface; Membrane protein, integral; Motility/polarity/chemotaxis; Receptor, misc. P97710 25528 3q36 rat Y477-p 451114 RPEDTLTyADLDMVH molecular association, regulation SHP-2(INDUCES) 9535915 5 8 18 -EPHB4 EphB4 EC 2.7.10.1; KINASE; Kinase, protein; Membrane protein, integral; Protein kinase, TK; Protein kinase, tyrosine (receptor) P54760 2050 7q22.1 human Y596-p 450855 VYIDPFTyEDPNEAV EphA2_TM molecular association, regulation; enzymatic activity, induced cell motility, induced; cell growth, induced; cytoskeletal reorganization RASA1(INDUCES) 11929761; 16950769; 37507023 3 26 198 -CRK CRK Adaptor/scaffold; Motility/polarity/chemotaxis; Oncoprotein Q04929 417553 chicken Y240-p 450357 NLQNGPFyARVIQKR SH3_2 molecular association, regulation; protein conformation Abl(DISRUPTS) 17289588 2 5 268 -RPTOR Raptor Adaptor/scaffold Q8N122 57521 17q25.3 human T908-p 23940710 LPSGRPGtTGPAGAQ activity, induced 22356909 1 1 0 leading to mTORC1 activation -UGDH UGDH Carbohydrate Metabolism - amino sugar and nucleotide sugar; Carbohydrate Metabolism - ascorbate and aldarate; Carbohydrate Metabolism - pentose and glucuronate interconversions; Carbohydrate Metabolism - starch and sucrose; EC 1.1.1.22; Motility/polarity/chemotaxis; Oxidoreductase O60701 7358 4p14 human Y473-p 4699451 VSSKRIPyAPSGEIP molecular association, regulation carcinogenesis, induced; cell motility, induced; RNA stability, induced; transcription, induced HuR(INDUCES) Other(INDUCES); Other(DISRUPTS) 31243371; 36896759 3 4 4 induces binding to UDP-Glc and hence disrupting interaction of HUR with UDP-Glc, facilitates easy release of UDP-GlcUA -PVRIG PVRIG Membrane protein, integral; Membrane protein, multi-pass Q6DKI7 79037 7q22.1 human Y233-p 53991100 QAALHVPyATINTSC molecular association, regulation SHP-2(INDUCES); SHP-1(INDUCES) 26755705 1 0 0 -SIAH1 SIAH1 Apoptosis; Cell development/differentiation; EC 6.3.2.-; EC 6.3.2.19; Ligase; Motility/polarity/chemotaxis; UBIQUITIN LIGASE; Ubiquitin conjugating system; Ubiquitin ligase Q8IUQ4 6477 16q12.1 human S19-p 2840508 GTSKCPPsQRVPALT molecular association, regulation; ubiquitination; activity, inhibited HIPK2(DISRUPTS) 18536714 1 0 0 facilitates HIPK2 polyubiquitination -HSPA1A HSP70 Chaperone; Heat shock protein; Motility/polarity/chemotaxis P0DMV8 3303 6p21.33 human K77-ac 40663225 AKRLIGRkFGDPVVQ HSP70 protein stabilization; molecular association, regulation; ubiquitination; enzymatic activity, induced apoptosis, inhibited CHIP(DISRUPTS); HIP(INDUCES); HSP40(DISRUPTS) Other(INDUCES) 27708256 2 1 2 induces binding to ATP and ATPase activity, inhibits ubiquitination -GRB14 GRB14 Adaptor/scaffold Q14449 2888 2q24.3 human S366-p 29576856 GCSSQSIsPMRSISE molecular association, regulation; phosphorylation INSR(DISRUPTS) 24535599; 28130417 2 5 0 -CYCS CYCS Apoptosis; Mitochondrial; Oxidoreductase; PHOSPHATASE; Protein phosphatase, Ser/Thr (non-receptor) P99999 54205 7p15.3 human Y49-p 473243 GQAPGYSyTAANKNK Cytochrom_C molecular association, regulation; protein conformation; enzymatic activity, induced apoptosis, inhibited COX4I1(DISRUPTS) 21706253; 28348229 4 4 4 donate electrons to complex IV -DDX5 DDX5 EC 3.6.4.13; Helicase; Nuclear receptor co-regulator; Nucleolus; RNA splicing; RNA-binding; Spliceosome P17844 1655 17q23.3 human R478-m2 1877752102 LLQLVEDrGSGRSRG molecular association, regulation XRN2(INDUCES) 31267554 1 1 0 represses R-loops -BORA BORA Activator Q6PGQ7 79866 13q21.33 human S112-p 27444813 TKDVIVPsPWTDHEG BORA_N molecular association, regulation; phosphorylation cell cycle regulation PLK1(INDUCES); AurA(INDUCES) 27068477; 33771996 3 3 0 -TTK TTK Cancer Testis Antigen (CTA); EC 2.7.12.1; KINASE; Kinase, protein; Protein kinase, Other; Protein kinase, dual-specificity (non-receptor) P33981 7272 6q14.1 human K472-sm 52485004 CFRTPVVkNDFPPAC molecular association, regulation cell cycle regulation BUB1B(DISRUPTS) 26675261 1 0 0 -UVSSA UVSSA Q2YD98 57654 4p16.3 human K414-ub 964554502 DFVEVPEkEGYEPHI intracellular localization 32142649 1 2 0 -AURKA AurA EC 2.7.11.1; KINASE; Kinase, protein; Oncoprotein; Protein kinase, Other; Protein kinase, Ser/Thr (non-receptor) A5GFW1 574063 pig S284-p 2370900 WSVHAPSsRRTTLCG Pkinase cell cycle regulation 18614302 2 0 0 -MAF1 MAF1 Transcription regulation Q9H063 84232 8q24.3 human S68-p 3211920 PPQTSGLsPSRLSKS Maf1 activity, inhibited transcription, induced 20233713; 20516213 2 15 0 -EEF1A1 EEF1A1 Nucleolus; Translation; Translation elongation P68104 1915 6q13 human S396-p 31884110 DGPKFLKsGDAAIVD GTP_EFTU_D3 translation, inhibited 33354788 1 7 0 -RRAGA RRAGA G protein regulator, misc. Q7L523 10670 9p22.1 human K244-ub 15397113 QFKLSCSkLAASFQS molecular association, regulation; phosphorylation autophagy, induced; signaling pathway regulation NPRL3(INDUCES); Raptor(DISRUPTS); DEPDC5(INDUCES); NPRL2(INDUCES) 25936802 1 3 2 interaction with GATOR1 complex, regulates mTORC1 signaling, regulates p70S6K phosphorylation -Mfn1 MFN1 EC 3.6.5.-; Hydrolase; Membrane protein, integral; Membrane protein, multi-pass; Mitochondrial Q811U4 67414 3 A3|3 15.75 cM mouse S86-p 1498941800 AFFGRTSsGKSSVIN Dynamin_N enzymatic activity, inhibited apoptosis, induced 30659190 1 1 0 -Trpm7 ChaK1 Channel, cation; EC 2.7.11.1; KINASE; Kinase, protein; Membrane protein, integral; Membrane protein, multi-pass; Protein kinase, Ser/Thr (non-receptor); Protein kinase, atypical Q923J1 58800 2|2 F1 mouse S1269-p 15499490 NEITRELsISKHLAQ activity, induced 30615643 1 7 1 cAMP dependent Ca2+ influx -ABHD5 ABHD5 EC 2.3.1.51; Lipase; Transferase Q8WTS1 51099 3p21.33 human S237-p 36744500 PDFKRKYsSMFEDDT Abhydrolase_1 protein stabilization; molecular association, regulation; protein conformation ABHD5(DISRUPTS) 35474805 2 1 0 -NF2 Merlin Cytoskeletal; Motility/polarity/chemotaxis; Tumor suppressor P35240 4771 22q12.2 human K449-ub 573763466 EESERRAkEADQLKQ ERM_helical molecular association, regulation; intracellular localization LATS1(DISRUPTS) 30918126 1 2 0 K63 kinked -Csf1r CSFR EC 2.7.10.1; KINASE; Kinase, protein; Membrane protein, integral; Oncoprotein; Protein kinase, TK; Protein kinase, tyrosine (receptor) P09581 12978 18 E1|18 34.41 cM mouse Y706-p 451528 NIHLEKKyVRRDSGF PK_Tyr_Ser-Thr activity, induced; enzymatic activity, induced cytoskeletal reorganization 1652061; 18519746; 7545432; 9000134 12 0 0 -Bad BAD Apoptosis O35147 64639 1q43 rat S113-p 447860 ETRSRHSsYPAGTEE Bcl-2_BAD molecular association, regulation apoptosis, altered 14-3-3 beta(INDUCES); Bcl-xL(DISRUPTS) 15994315; 19344769 129 22 172 -KLF8 KLF8 C2H2-type zinc finger protein; DNA-binding; Transcription factor O95600 11279 Xp11.21 human K93-ac 25344505 PVDLSFHkPKAPLQP sumoylation; molecular association, regulation cell cycle regulation; transcription, inhibited CTBP1(DISRUPTS) 21416054 1 1 0 inhibits sumoylation at KLF8-K67 -Ntrk2 TrkB EC 2.7.10.1; KINASE; Kinase, protein; Membrane protein, integral; Protein kinase, TK; Protein kinase, tyrosine (receptor) P15209 18212 13 B1|13 31.2 cM mouse S478-p 478364 SNDDDSAsPLHHISN molecular association, regulation cytoskeletal reorganization TIAM1(INDUCES) 17341134; 23064382 2 1 0 impaired hippocampal LTP, and impaired memory in water maize and novel object recognition ; dendritic spine density in response to BDNF; dendritic growth -ARHGEF9 ARHGEF9 GAP; GAP, Rac/Rho O43307 23229 Xq11.1 human K515-ub 1873595602 FSRLTPFkK______ protein degradation 29069083 1 0 0 regulates gephyrin clustering and dendritic arborization -EIF2B5 eIF2B-epsilon Translation; Translation initiation Q13144 8893 3q27.1 human S525-p 470490 KINMEEEsESESEQS activity, induced translation, altered 18160716 1 1 0 eIF2B-epsilon [S525A] mutation abolished regulation of protein synthesis by amino acids -Bcl2l11 BIM Apoptosis O54918 12125 2|2 F1 mouse T112-p 449071 SCDKSTQtPSPPCQA protein stabilization; molecular association, regulation apoptosis, altered; apoptosis, induced Bcl-2(INDUCES); Bcl-xL(INDUCES) 18498746; 19841067; 23832115 10 1 0 -NPR1 ANPA EC 4.6.1.2; Guanylyl cyclase; KINASE; Kinase, protein; Lyase; Membrane protein, integral; Nucleotide Metabolism - purine; Protein kinase, RGC; Protein kinase, dual-specificity (receptor); Receptor, misc. P16066 4881 1q21.3 human S529-p 447512 RHLRSAGsRLTLSGR activity, induced; enzymatic activity, induced 28416574; 9528788 3 3 0 -Aurkb AurB EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, Other; Protein kinase, Ser/Thr (non-receptor) O70126 20877 11 B3|11 42.32 cM mouse K102-ub 40212805 NVYLAREkKSRFIVA Pkinase protein degradation cell cycle regulation; carcinogenesis, inhibited; apoptosis, induced 23928698 1 0 0 -MCM2 MCM2 DNA-binding; EC 3.6.4.12 P49736 4171 3q21.3 human S27-p 452310 GNDPLTSsPGRSSRR activity, induced; molecular association, regulation cell cycle regulation; chromatin organization, altered DNA(NOT_REPORTED); DNA(INDUCES) 16446360; 16899510 4 97 63 MMCM2 phosphorylated forms are differentially bound to chromatin. ; regulates ATPase activity in vitro -Mapk1 ERK2 EC 2.7.11.24; KINASE; Kinase, protein; Protein kinase, CMGC; Protein kinase, Ser/Thr (non-receptor) P63085 26413 16 A3|16 10.53 cM mouse T188-p 3949250 FLTEYVAtRWYRAPE Pkinase intracellular localization cytoskeletal reorganization; cell growth, altered 19060905 4 17 17 T 188 phosphorylation induces ERK nuclear localization and cardiac hypertrophy. -PPIA PPIA Cyclophilin; EC 5.2.1.8; Isomerase; RNA-binding P62937 5478 7p13 human K82-ac 461597 GKSIYGEkFEDENFI Pro_isomerase exocytosis, induced; cell adhesion, induced; signaling pathway regulation 24293519 2 8 45 secretion in VSMC, regulates VSMC activation pathway -USF2 USF2 DNA-binding; Transcription factor Q15853 7392 19q13.12 human S155-p 36392500 NPFSNGGsPAAEAVS protein stabilization; molecular association, regulation; protein conformation carcinogenesis, induced; cell growth, induced; cell motility, induced; transcription, induced DNA(INDUCES) 25238393; 31013770 2 3 0 target gene transcription of HO-1, PAI-1, and FAS; Increase in USF2 mRNA expresssion was observed in MDA-MB-231 CDK5 knockout cells -Pou3f2 Oct7 DNA-binding; Motility/polarity/chemotaxis; Transcription factor P31360 18992 4 A3|4 9.73 cM mouse T361-p 22996304 GRKRKKRtSIEVSVK Homeodomain cell cycle regulation; cell motility, induced; transcription, induced 22290434 1 0 0 mutation of this site inhibits PAX3 transcription, but not MITF-M transcription -HTT Huntingtin Cytoskeletal P42858 3064 4p16.3 human S2548-p 40422837 TRFGRKLsIIRGIVE protein degradation 35908190 2 3 0 -STAT4 STAT4 DNA-binding; Transcription factor Q14765 6775 2q32.2-q32.3 human Y693-p 447790 TERGDKGyVPSVFIP molecular association, regulation; intracellular localization cell differentiation, inhibited STAT4(INDUCES); LIFR(INDUCES); STAT3(INDUCES) 30770344 10 5 8 -ARHGAP31 CdGAP GAP; GAP, Rac/Rho Q2M1Z3 57514 3q13.32-q13.33 human S1178-p 484822 ALTGRRNsAPVSVSA molecular association, regulation; intracellular localization transcription, induced; cytoskeletal reorganization; cell motility, inhibited 14-3-3 beta(INDUCES); 14-3-3 sigma(INDUCES) 29545927 1 28 2 14-3-3? inhibits the ability of CdGAP to repress the E-cadherin promoter and to induce cell migration; 14-3-3? sequesters CdGAP into the cytoplasm and inhibits its ability to induce cell rounding -MLH1 MLH1 Cell cycle regulation; DNA repair, damage; Tumor suppressor P40692 4292 3p22.2 human S406-p 12217082 PLSKPLSsQPQAIVT protein stabilization 21864706 1 2 0 -CDKN1A p21Cip1 Cell cycle regulation; Inhibitor P38936 1026 6p21.2 human K154-ub 9897005 MTDFYHSkRRLIFSK protein degradation; ubiquitination cell cycle regulation; carcinogenesis, induced; cell growth, induced 13678583; 17429006; 28446751 5 1 0 -Set SET Apoptosis; DNA replication; DNA-binding; Inhibitor; Nuclear receptor co-regulator; Oncoprotein; Protein phosphatase, regulatory subunit Q9EQU5 56086 2|2 B mouse S7-p 455972 _MAPKRQsAILPQPK protein degradation 30052687 2 39 0 SET protein down regulation through proteosome pathway -RAPH1 RAPH1 Adaptor/scaffold; Motility/polarity/chemotaxis Q70E73 65059 2q33.2 human Y513-p 477344 GKQLYMNyQEALKRT molecular association, regulation cell motility, induced 26996666 2 0 1 Lpd-Scar/WAVE interaction is positively regulated by c-Abl and c-Src, breast cancer cell invasion -BARD1 BARD1 EC 6.3.2.-; EC 6.3.2.19; Ligase; UBIQUITIN LIGASE; Ubiquitin conjugating system; Ubiquitin ligase Q99728 580 2q35 human T394-p 455773 FISLSPGtPPSTLSS cell cycle regulation 15855157 1 10 1 resistance to genotoxic stress (mitomycin C) -Ikbkb IKKB EC 2.7.11.10; KINASE; Kinase, protein; Protein kinase, Other; Protein kinase, Ser/Thr (non-receptor) O88351 16150 8|8 A2 mouse K238-ub 1881186500 WHSKVRQkSEVDIVV molecular association, regulation; phosphorylation NFkB-p105(DISRUPTS) 33523871 1 1 0 ubiquitylation inhibits phosphorylation of p105 -TOP2A TOP2A EC 5.99.1.3; Isomerase P11388 7153 17q21.2 human S1213-p 452237 QMAEVLPsPRGQRVI intracellular localization cell cycle regulation 11699638; 27407105; 30871006 6 65 5 -Spag9 JIP4 iso2 Adaptor/scaffold; Cancer Testis Antigen (CTA) Q58A65-2 70834 11|11 D mouse T351-p 3952367 SGYKGSStPTKGIEN molecular association, regulation FOXK2(INDUCES); PLK1(INDUCES); FOXK1(INDUCES) 26468278 1 6 12 -HDAC1 HDAC1 DEACETYLASE; Deacetylase; EC 3.5.1.98; Hydrolase; Nuclear receptor co-regulator P56517 373961 chicken S406-p 3195746 EDPEKRIsIRNSDKR protein stabilization; molecular association, regulation transcription, induced MBD3(DISRUPTS); HDAC2(INDUCES); MTA1(DISRUPTS) 33596269 2 11 0 no effect on homodimerization -Kcnj1 ROMK Channel, potassium; Membrane protein, integral; Membrane protein, multi-pass P35560 24521 8q21 rat S44-p 449605 RQRARLVsKEGRCNI IRK activity, induced; intracellular localization; protein conformation 12878206; 16118216; 18311184; 29115510 9 0 0 translocates to the plasma membrane -COFILIN Cofilin-1 Cytoskeletal; Motility/polarity/chemotaxis; Nuclear receptor co-regulator P10668 445532 pig S3-p 448444 _____MAsGVAVSDG molecular association, regulation cytoskeletal reorganization ACTB(DISRUPTS) 9078368 97 69 3 S3D mutant disrupts colocalization with actin. S3D mutant fails to rescue cof-1-defective mutant of budding yeast. -Dcp1a DCP1A EC 3.-.-.-; Hydrolase; RNA processing; Transcription, coactivator/corepressor Q91YD3 75901 14 B|14 18.75 cM mouse S335-p 3213294 PSYTLPLsPVLSPTL molecular association, regulation DCP2(INDUCES) 23637887 4 29 10 -OTUB1 OTUB1 DEUBIQUITINASE; EC 3.4.19.12; Protease; Ubiquitin conjugating system; Ubiquitin-specific protease Q96FW1 55611 11q13.1 human Y26-p 14821305 EGVNCLAyDEAIMAQ molecular association, regulation; enzymatic activity, induced carcinogenesis, induced; cell growth, induced; apoptosis, inhibited UBE2D1(INDUCES); Raptor(INDUCES); YpkA(INDUCES); UBE2W(NOT_REPORTED); UBE2N(INDUCES) 20553488; 35927303; 37330581 3 2 0 -Kif21a KIF21A Microtubule-binding; Motor Q9QXL2 16564 15 E3|15 45.86 cM mouse T1161-p 487251 KARRRTTtQMELLYA molecular association, regulation ANKRD15(DISRUPTS) 29158259 1 0 1 -ADD2 ADD2 Cytoskeletal; Motility/polarity/chemotaxis P35612 119 2p13.3 human Y489-p 449419 PNQFVPLyTDPQEVL intracellular localization 16765915 2 4 141 -Foxo1 FOXO1A DNA-binding; Nuclear receptor co-regulator; Oncoprotein; Transcription factor G3V7R4 84482 2q26 rat S206-p 4258803 SSAGWKNsIRHNLSL Forkhead molecular association, regulation; intracellular localization apoptosis, induced 14-3-3 beta(DISRUPTS) 19221179 3 1 0 total 14-3-3 proteins -IFI16 IFI16 Transcription factor Q16666 3428 1q23.1 human K3-ub 1877844700 _____MGkKYKNIVL protein degradation signaling pathway regulation STING(INDUCES) 31665637 1 1 0 IFI16 degradation inhibits viral DNA-induced IFN-I production -GRB10 GRB10 Adaptor/scaffold Q13322 2887 7p12.1 human T155-p 22312200 PGSPPVLtPGSLPPS protein stabilization 21659604 1 0 0 -Gphn gephyrin Adaptor/scaffold; EC 2.10.1.1; EC 2.7.7.75 Q03555 64845 6q24 rat S283-p 2020113 LSTTPSEsPRAQATS protein stabilization; protein conformation neural plasticity; signaling pathway regulation 23408424; 25093719; 31835170 10 23 2 GABA-R signaling-regulates GABA-R diffusion and binding at synapses -SORBS3 vinexin iso2 Adaptor/scaffold; Cell adhesion; Motility/polarity/chemotaxis; Nuclear receptor co-regulator O60504-2 10174 8p21.3 human S188-p 452554 DGPQLPTsPRLTAAA cell growth, induced; cell motility, inhibited; cell adhesion, inhibited 17486060 3 46 40 -Sh3bp4 SH3BP4 Cell cycle regulation; Vesicle Q921I6 98402 1|1 D mouse S245-p 3214461 FRSKRSYsLSELSVL molecular association, regulation 14-3-3 beta(INDUCES) 19122209 2 39 0 -EEF1D EEF1D iso2 Translation; Translation elongation P29692-2 1936 8q24.3 human S499-p 455672 APQTQHVsPMRQVEP transcription, inhibited 33521052 2 108 49 -Ripk1 RIPK1 EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, Ser/Thr (non-receptor); Protein kinase, TKL Q60855 19766 13 A3.3|13 14.01 cM mouse S332-p 4728172 DCVPLPPsRSNSEQP molecular association, regulation; enzymatic activity, induced RIPK3(INDUCES) 28842570 1 3 2 necroptosis -CD300LF IREM-1 Immunoglobulin superfamily; Membrane protein, integral; Receptor, misc. Q8TDQ1 146722 17q25.1 human Y236-p 474548 VDQVEVEyVTMASLP SIT activity, induced; molecular association, regulation; enzymatic activity, induced PIK3R1(INDUCES) 17202342; 32152116 3 0 0 activation of PLC gamma which leads to the activation of PKC; involved in rat basophilic leukemia cell degranulation -Map3k7 TAK1 EC 2.7.11.25; KINASE; Kinase, protein; Protein kinase, Ser/Thr (non-receptor); Protein kinase, TKL Q62073 26409 4|4 A5 mouse S192-p 448289 HMTNNKGsAAWMAPE PK_Tyr_Ser-Thr phosphorylation; enzymatic activity, induced TAB1(INDUCES) 10702308; 27542620 5 1 0 O-GlcNAc modi?cation TAK1 autophosphorylation -IGF1R IGF1R EC 2.7.10.1; KINASE; Kinase, protein; Membrane protein, integral; Protein kinase, TK; Protein kinase, tyrosine (receptor) P08069 3480 15q26.3 human Y1346-p 448389 SFDERQPyAHMNGGR molecular association, regulation; enzymatic activity, induced cell differentiation, altered; cell growth, altered Src(INDUCES) 10786694; 16037379 3 7 28 observed in quadruple mutant Y980/1280/1281/1346F -Scnn1a ENaC-alpha Channel, sodium; Membrane protein, integral; Membrane protein, multi-pass; Transporter, ion channel P37089 25122 4q42 rat S617-p 1877164902 MLLRRFRsRYWSPGR activity, inhibited 35525869 1 0 0 -CHEK2 Chk2 EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, CAMK; Protein kinase, Ser/Thr (non-receptor); Tumor suppressor O96017 11200 22q12.1 human S210-p 12473000 DLTVDDQsVYPKALR enzymatic activity, inhibited cell cycle regulation 20126263 1 1 0 mutation of this site impairs checkpoint recovery -VIM Vimentin Cytoskeletal; Motility/polarity/chemotaxis P08670 7431 10p13 human S26-p 451767 GTASRPSsSRSYVTT Filament_head molecular association, regulation cytoskeletal reorganization Vimentin(DISRUPTS) 11895474 4 15 0 -NPM1 NPM1 Nucleolus; Oncoprotein; RNA-binding; Translation P06748 4869 5q35.1 human S10-p 7105368 DSMDMDMsPLRPQNY molecular association, regulation; intracellular localization; phosphorylation cell cycle regulation CDC25C(INDUCES) 19933706 3 30 0 mutation of S10/S70 to alanine increases CDK1 Y15 phosphorylation; mutation of S10/70 to glutamate decreases Cdc25C S216 phosphorylation -TRPM8 TRPM8 Channel, cation; Membrane protein, integral; Membrane protein, multi-pass Q7Z2W7 79054 2q37.1 human T17-p 12570902 MRNRRNDtLDSTRTL activity, induced 20110357 1 0 0 -RPS6KA1 p90RSK EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, AGC; Protein kinase, Ser/Thr (non-receptor); Translation Q15418 6195 1p36.11 human T359-p 447992 DTEFTSRtPKDSPGI Pkinase_C enzymatic activity, induced 23708659 41 28 2 -MBD4 MBD4 Apoptosis; DNA repair, damage; Deoxyribonuclease; EC 3.2.2.- O95243 8930 3q21.3 human K137-sm 1877787600 KNGETSLkPEDFDFT MBD DNA repair, induced 31476572 1 1 0 -Snca SNCA Adaptor/scaffold O55042 20617 6 B3|6 29.15 cM mouse K10-ac 63341501 VFMKGLSkAKEGVVA Synuclein molecular association, regulation; intracellular localization autophagy, induced; cytoskeletal reorganization SNCA(DISRUPTS) Other(DISRUPTS) 28257421 1 1 0 inhibits binding to lipid membranes -PLCG2 PLCG2 Carbohydrate Metabolism - inositol phosphate; EC 3.1.4.11; Motility/polarity/chemotaxis; Phospholipase P16885 5336 16q23.3 human Y1217-p 447939 LNNQLFLyDTHQNLR enzymatic activity, induced signaling pathway regulation 30344948; 35639855 19 15 346 regulates B cell receptor (BCR) signaling; intramolecular tyrosine-phosphorylation and Rac mediated activation -Pparg PPAR-gamma DNA-binding; Nuclear receptor; Transcription factor P37238 19016 6 E3|6 53.41 cM mouse K107-sm 3617602 QEYQSAIkVEPASPP PPARgamma_N molecular association, regulation; activity, inhibited cell differentiation, inhibited; cell motility, induced; cell growth, induced; apoptosis, inhibited; transcription, altered; transcription, inhibited DNA(DISRUPTS) 16534556; 18832723; 19339015; 20950277; 34249943 15 0 0 SENP3 desumoylated PPAR-gamma and enhanced its activity to promote-the expression of adipogenic marker genes such as C/EBPa, adiponectin and FABP4 -ETV6 Tel DNA-binding; Motility/polarity/chemotaxis; Oncoprotein; Transcription factor P41212 2120 12p13.2 human K11-sm 2798320 TPAQCSIkQERISYT protein degradation; molecular association, regulation transcription, induced DNA(DISRUPTS) 18212042 1 3 0 Tel monomer sumoylation induces degradation -NR3C1 GR DNA-binding; Mitochondrial; Nuclear receptor; Transcription factor P04150 2908 5q31.3 human T594-p 1872513509 LHLDDQMtLLQYSWM Hormone_recep molecular association, regulation 14-3-3 zeta(INDUCES) 33744286 1 0 0 -CAST calpastatin Inhibitor P20810 831 5q15 human S133-p 7320476 DKKKEKKsLTPAVPV Calpain_inhib enzymatic activity, inhibited 36984009 1 14 2 inhibits calpain activity -Pex14 PEX14 Adaptor/scaffold Q642G4 64460 5q36 rat S252-p 27996231 VKSPSPSsPAAVNHH molecular association, regulation; intracellular localization Catalase(DISRUPTS) 32831175 1 9 0 regulates peroxisomal catalase import -H2AFZ H2AZ DNA-binding Q5ZMD6 426361 chicken K7-ac 458910 _AGGKAGkDSGKTKT Histone chromatin organization, altered 19385636 4 14 419 K4, K7, and K11 acetylation destabilizes the nucleosome core particle (NCP) -ACSL4 ACSL4 EC 6.2.1.3; Ligase; Lipid Metabolism - fatty acid; Membrane protein, integral O60488 2182 Xq23 human K498-ub 15383881 PLICCEIkLKDWQEG AMP-binding protein degradation 37428466 1 3 2 inhibition of ACSL4-driven lipid peroxidation and ferroptosis is necessary for CDK1 to promote oxaliplatin resistance in CRC -Rasgrf1 RASGRF1 GEF; GEF, Ras P28818 192213 8q31 rat S781-p 18710205 GKTTLDTsKLCVASS protein degradation 21382555 1 1 0 -MAZ MAZ C2H2-type zinc finger protein; RNA-binding; Transcription factor P56270 4150 16p11.2 human T385-p 449095 KDRLRAHtVRHEEKV transcription, induced DNA(DISRUPTS) 26902421 2 0 0 p53 expression -EIF4G1 eIF4G iso8 RNA-binding; Translation; Translation initiation Q04637-8 1981 3q27.1 human S1239-p 18910225 SPLKAALsEEELEKK molecular association, regulation; phosphorylation Mnk1(INDUCES); eIF3-alpha(DISRUPTS); EIF4B(DISRUPTS); EIF4A1(DISRUPTS) 23263986 1 19 4 induces phosphorylation at S1232; controls formation of translation initiation complex -GYS1 GYS1 Carbohydrate Metabolism - starch and sucrose; EC 2.4.1.11; Transferase P13834 100008660 rabbit S8-p 449898 MPLSRTLsVSSLPGL enzymatic activity, inhibited 10909964; 7929255 16 1 0 simultaneous mutation of both NH2- and COOH-terminal sites was necessary to cause substantial increases in the activity ratio. -CEP131 CEP131 Calcium-binding Q9UPN4 22994 17q25.3 human S21-p 41451326 SPAGVDLsLTGLPPP molecular association, regulation; intracellular localization carcinogenesis, induced; cytoskeletal reorganization; signaling pathway regulation STIL(INDUCES) 31358734 1 3 0 interaction with STIL promotes STIL relocation to the centrioles -CAMK1 CAMK1A EC 2.7.11.17; KINASE; Kinase, protein; Protein kinase, CAMK; Protein kinase, Ser/Thr (non-receptor) Q14012 8536 3p25.3 human T177-p 448527 DPGSVLStACGTPGY Pkinase enzymatic activity, induced 24841198 10 6 7 -MEFV pyrin Actin-binding O15553 4210 16p13.3 human S242-p 455899 SGKMRPRsLEVTIST molecular association, regulation; intracellular localization; activity, inhibited 14-3-3 beta(INDUCES); 14-3-3 theta(INDUCES); 14-3-3 epsilon(INDUCES) 15934090; 27030597; 27270401; 36342970; 36384121 8 7 0 -FYB1 SLAP-130 Adaptor/scaffold O15117 2533 5p13.1 human Y780-p 459246 DIADGCIyDND____ hSH3 cell adhesion, altered 20661443 2 2 17 promotes adhesion to ICAM-1 -GRM7 mGluR7 GPCR, family 3; Membrane protein, integral; Membrane protein, multi-pass; Receptor, GPCR Q14831 2917 3p26.1 human S862-p 2846504 NVQKRKRsFKAVVTA sumoylation 26631532 4 0 0 Ser862 phosphorylation promotes SUMOylation of mGluR7 -AKAP12 AKAP12 Adaptor/scaffold Q02952 9590 6q25.1 human T767-p 3801512 ESFKRLVtPRKKSKS WSK molecular association, regulation; intracellular localization cell cycle regulation; cell growth, induced PLK1(INDUCES) 23063527 2 2 2 -Rb1 Rb Nuclear receptor co-regulator; Oncoprotein; Transcription, coactivator/corepressor; Tumor suppressor P13405 19645 14 38.73 cM|14 D3 mouse S787-p 466966 RSPYKFSsSPLRIPG Rb_C cell cycle regulation; transcription, inhibited 9671466 1 5 70 transcriptional downregulation of the E2F-1, E2F-2, dihydrofolate reductase, thymidine kinase, c-myc, proliferating-cell nuclear antigen, p107, and p21/Cip1 genes -Chek1 Chk1 EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, CAMK; Protein kinase, Ser/Thr (non-receptor); Tumor suppressor O35280 12649 9|9 A4 mouse S301-p 465528 IHSNLDFsPVNNGSS intracellular localization 19837665 5 22 5 -CCNB1 CCNB1 Activator; Cell cycle regulation P14635 891 5q13.2 human S116-p 13256100 PVKEEKLsPEPILVD intracellular localization DNA(INDUCES) 20117088; 22726437 2 1 0 enhances nuclear import -APP APP iso8 Apoptosis; Cell surface; Membrane protein, integral; Receptor, misc.; Transcription factor P05067-8 351 21q21.3 human Y743-p 450343 NGYENPTyKFFEQMQ APP_amyloid protein processing 8132561 4 12 238 -MDM4 MDM4 EC 6.3.2.-; Ligase; UBIQUITIN LIGASE; Ubiquitin conjugating system; Ubiquitin ligase O15151 4194 1q32.1 human S96-p 455615 SFSVKDPsPLYDMLR intracellular localization 15735705 1 0 0 -SIAH1 SIAH1 Apoptosis; Cell development/differentiation; EC 6.3.2.-; EC 6.3.2.19; Ligase; Motility/polarity/chemotaxis; UBIQUITIN LIGASE; Ubiquitin conjugating system; Ubiquitin ligase Q8IUQ4 6477 16q12.1 human Y100-p 457101 SVLFPCKyASSGCEI Sina protein stabilization apoptosis, altered 16230351 1 0 0 -GNAI1 G-alpha i1 G protein; G protein, heterotrimeric; G protein, heterotrimeric alpha G((i/o/t/z)) P63096 2770 7q21.11 human Y320-p 22641096 RKDTKEIyTHFTCAT G-alpha enzymatic activity, induced carcinogenesis, induced; signaling pathway regulation 33139573 1 1 2 -OGG1 OGG1 DNA repair, damage; Deoxyribonuclease; EC 4.2.99.18; Lyase O15527 4968 3p25.3 human K341-ac 40320203 AKRRKGSkGPEG___ DNA repair, induced; apoptosis, inhibited 25660075 1 0 0 -BCL2L11 BIM Apoptosis O43521 10018 2q13 human S87-p 458219 FIFMRRSsLLSRSSS apoptosis, altered; signaling pathway regulation 16282323; 30923040 2 10 1 upregulation of Hedgehog signaling in CLL cells -TTK TTK Cancer Testis Antigen (CTA); EC 2.7.12.1; KINASE; Kinase, protein; Protein kinase, Other; Protein kinase, dual-specificity (non-receptor) P33981 7272 6q14.1 human K71-sm 52485005 DWLSLLLkLEKNSVP molecular association, regulation cell cycle regulation BUB1B(DISRUPTS) 26675261 1 0 0 -STK38 NDR1 EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, AGC; Protein kinase, Ser/Thr (non-receptor) Q15208 11329 6p21.31 human T74-p 460658 SAHARKEtEFLRLKR molecular association, regulation; phosphorylation cytoskeletal reorganization MOB1A(INDUCES); S100B(INDUCES); MOB1B(NOT_REPORTED) 12493777; 19836237 3 0 0 NDR1 Y31A and Y74A mutants showed highly decreased T444 phosphorylation and centrosome amplification. -LALBA LALBA Apoptosis; Secreted; Secreted, signal peptide; Transferase P00711 281894 cow S89-p 1875112302 DDQNPHSsNICNISC Lys molecular association, regulation; protein conformation IGE(DISRUPTS); IgG(DISRUPTS) 34655828 0 1 0 -KRT18 K18 Cytoskeletal; Nucleolus P05783 3875 12q13.13 human S34-p 447733 RPVSSAAsVYAGAGG molecular association, regulation; intracellular localization; phosphorylation cell motility, induced; apoptosis, induced; cytoskeletal reorganization 14-3-3 beta(INDUCES); 14-3-3 zeta(INDUCES) 10623656; 11917136; 14694114; 15368451; 19246484; 27059955 14 27 13 O-GlcNAcylation at S31 determines the occurrence of phosphorylation at S34, maintaining the normal filament organization of keratin 18 -SIRT1 SIRT1 Apoptosis; DEACETYLASE; Deacetylase; EC 3.5.1.-; Nuclear receptor co-regulator Q96EB6 23411 10q21.3 human K519-ub 1877148900 EKPPRTQkELAYLSE protein degradation carcinogenesis, inhibited; cell growth, inhibited; cell motility, inhibited 32361710 1 1 0 -PINX1 PINX1 Inhibitor; Nucleolus; Tumor suppressor Q96BK5 54984 8p23.1 human S226-p 14823405 ATGKDVEsYLQPKAK protein degradation; ubiquitination 20573420 1 1 0 -Stmn1 STMN1 Cytoskeletal P13668 29332 5q36 rat S38-p 448556 SVPEFPLsPPKKKDL Stathmin apoptosis, inhibited; cytoskeletal reorganization 24302736; 25285524; 31933182 49 114 166 increase microtubule depolymerization -Mlkl MLKL KINASE; Kinase, protein; Protein kinase, Ser/Thr (non-receptor); Protein kinase, TKL Q9D2Y4 74568 8|8 E1 mouse T349-p 8148779 TQNSISRtAKSTKAE PK_Tyr_Ser-Thr protein conformation 26024392 2 1 1 -MAP2K1 MEK1 EC 2.7.12.2; KINASE; Kinase, protein; Protein kinase, STE; Protein kinase, dual-specificity (non-receptor) Q02750 5604 15q22.31 human K175-ac 35480411 KVSIAVIkGLTYLRE Pkinase enzymatic activity, induced cell growth, induced; transcription, induced; signaling pathway regulation 24681949; 34965411 2 0 0 activation of dynamin-related protein 1 (DRP1), metabolic reprogramming, glycolytic switching -Rps6kb1 p70S6K EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, AGC; Protein kinase, Ser/Thr (non-receptor); Translation Q8BSK8 72508 11|11 C mouse T444-p 448358 RFIGSPRtPVSPVKF molecular association, regulation; enzymatic activity, induced cell differentiation, altered DEDD(INDUCES) 10846175; 19106089 106 37 109 -FXR1 FXR1 RNA-binding; Translation P51114 8087 3q26.33 human S420-p 467926 SERKDELsDWSLAGE FXMRP1_C_core intracellular localization 20417602 1 28 26 -AKT1 Akt1 EC 2.7.11.1; KINASE; Kinase, protein; Oncoprotein; Protein kinase, AGC; Protein kinase, Ser/Thr (non-receptor) P31749 207 14q32.33 human K301-sm 31089527 GLCKEGIkDGATMKT Pkinase cell cycle regulation; RNA splicing, induced 24013425 1 0 0 -DPYSL2 CRMP-2 Microtubule-binding; Motility/polarity/chemotaxis Q16555 1808 8p21.2 human Y499-p 463170 RGVPRGLyDGPVCEV molecular association, regulation cytoskeletal reorganization 29396402 1 9 327 signi?cantly impair the microtubule bundling activity of CRMP2, impaired binding to microtubules -KHDC3L KHDC3L Cell cycle regulation Q587J8 154288 6q13 human T156-p 25285513 VEVREAGtQRSVEVQ activity, induced; molecular association, regulation DNA repair, induced; cell growth, induced PARP1(INDUCES) 31609975 1 0 1 -PSEN1 PSEN1 Cell surface; EC 3.4.23.-; Membrane protein, integral; Membrane protein, multi-pass; Mitochondrial; Protease P49768 5663 14q24.2 human S353-p 448562 SHLGPHRsTPESRAA Presenilin molecular association, regulation; intracellular localization; protein conformation cell growth, altered CTNNB1(DISRUPTS); CDH2(DISRUPTS); CTNNB1(INDUCES) 11104755; 17360711; 17389597 3 0 9 GSK3beta activation downregulates PI3K/Akt signaling probably by reducing the interaction of PSEN1 with N-cadherin (CDH2)/ beta catenin (CTNNB1); reduced interaction was observed in the constitutively active GSK3beta (S9A) mutant; stabilizes beta catenin by reducing its ubiquitination and turn-over -Slc12a1 NKCC2 Membrane protein, integral; Membrane protein, multi-pass; Transporter; Transporter, SLC family P55014 20495 2 F1|2 61.23 cM mouse T101-p 458228 LQTFGHNtMDAVPKI AA_permease_N activity, induced 12732642; 24808538 14 2 0 -TP53 p53 Activator; DNA-binding; Motility/polarity/chemotaxis; Nuclear receptor co-regulator; Transcription factor; Tumor suppressor P04637 7157 17p13.1 human K372-ac 458982 HSSHLKSkKGQSTSR protein degradation; molecular association, regulation; protein stabilization; ubiquitination; intracellular localization cell growth, induced; cell growth, inhibited; apoptosis, induced; transcription, induced; transcription, altered polybromo 1(INDUCES); BCL2L2(INDUCES); p21Cip1(DISRUPTS) DNA(INDUCES) 11094089; 11099047; 11250899; 11971195; 12421820; 14982997; 16291740; 18485870; 19339993; 19377469; 21297583; 31680191; 31863007; 36257192; 9288740 25 3 0 promoting the C-terminal acetylation of p53 and may facilitate p53-dependent gene expression ; PBRM1 is a reader for p53 acetylation on lysine 382 (K382Ac); 20, 164, 305, 320, 370/372/373, 381/382/386 K-R mutants diminsished transactivation, and selective regulation of target genes expression through distinct mechanisms; ZNF420 (Apak) represses p53 activity by attenuating its acetylation -Lhcgr LHR GPCR, family 1; Membrane protein, integral; Membrane protein, multi-pass; Receptor, GPCR P16235 25477 6q12 rat S675-p 451064 KNGFPGAsKPSQATL receptor internalization, altered 9660797 1 0 0 S675 is essential for agonist-induced internalization but not for agonist-induced uncoupling. -EPAS1 HIF2A DNA-binding; Transcription factor Q99814 2034 2p21 human T528-p 59087902 FNELDLEtLAPYIPM HIF-1 intracellular localization transcription, induced 27686097 2 1 0 EPO secretion, inhibits CRM1-dependent nuclear export of HIF2A -KCNK2 TREK-1 iso2 Channel, potassium; Membrane protein, integral; Membrane protein, multi-pass O95069-2 3776 1q41 human S333-p 456161 KETRRRLsVEIYDKF activity, inhibited neural plasticity 33006141 8 5 0 -STAT5B STAT5B DNA-binding; Oncoprotein; Transcription factor P51692 6777 17q21.2 human Y743-p 448736 PQAHYNMyPQNPDSV activity, inhibited transcription, altered; transcription, inhibited 16772534; 17822672 4 0 0 transcriptional activation of STAT5B Y740/743 mutant requires phosphorylation of S731 and Y699 -HADHA HADHA ACETYLTRANSFERASE; Acetyltransferase; Amino Acid Metabolism - lysine degradation; Amino Acid Metabolism - tryptophan; Amino Acid Metabolism - valine, leucine and isoleucine degradation; Carbohydrate Metabolism - butanoate; Carbohydrate Metabolism - propanoate; EC 1.1.1.211; EC 4.2.1.17; Lipid Metabolism - fatty acid; Lipid Metabolism - fatty acid elongation in mitochondria; Lipid Metabolism - unsaturated fatty acid biosynthesis; Lyase; Mitochondrial; Other Amino Acids Metabolism - beta-alanine; Oxidoreductase; Secondary Metabolites Metabolism - limonene and pinene degradation P40939 3030 2p23.3 human K406-ac 461764 RGQQQVFkGLNDKVK 3HCDH_N protein stabilization 27457618 2 9 23 3 sites can be acetylated or ubiquitylated, acetylation blocks ubiquitylation -TP53 p53 Activator; DNA-binding; Motility/polarity/chemotaxis; Nuclear receptor co-regulator; Transcription factor; Tumor suppressor P04637 7157 17p13.1 human K320-ac 458976 SSSPQPKkKPLDGEY P53_tetramer activity, induced; protein stabilization; molecular association, regulation; intracellular localization carcinogenesis, inhibited; cell growth, inhibited; apoptosis, induced; transcription, induced; neural plasticity; cell growth, induced; apoptosis, inhibited; transcription, inhibited p53(INDUCES); SIN3A(INDUCES); PCAF(INDUCES) DNA(INDUCES) 10891493; 11250899; 12501250; 12716906; 15141169; 16540664; 16717128; 16946709; 17403783; 17977830; 18419600; 18574470; 19265193; 19339993; 20094059; 21297583; 23329847; 24330748; 27208501; 31196136; 31296660; 31634504; 31680191; 35534985; 9744860; 9891054 56 2 0 -RXRA RXRA DNA-binding; Motility/polarity/chemotaxis; Nuclear receptor P19793 6256 9q34.2 human S49-p 333674901 GSPGQLHsPISTLSS Nuc_recep-AF1 ubiquitination carcinogenesis, induced; transcription, induced; signaling pathway regulation 29137318; 30518934 2 0 0 PI3K/AKT signaling ; PIK3CA transcription; negatively regulated beta-catenin expression by ubiquitination of ?-catenin in CRC -Flnc FLNC Cytoskeletal; Motility/polarity/chemotaxis Q8VHX6 68794 6 A3.3|6 12.36 cM mouse S2625-p 15403523 SSSSRGAsYSSIPKF protein stabilization 28028127 1 15 0 -MEF2D MEF2D DNA-binding; Transcription factor Q14814 4209 1q22 human K267-m2 31094531 QLGAPSRkPDLRVIT molecular association, regulation cell differentiation, inhibited; transcription, inhibited DNA(DISRUPTS) 24078251 1 1 0 -POU5F1 Oct4 DNA-binding; Transcription factor Q01860 5460 6p21.33 human S93-p 25236708 PQGGLETsQPEGEAG transcription, induced 33565603 2 1 0 -MAP2K6 MKK6 EC 2.7.12.2; KINASE; Kinase, protein; Protein kinase, STE; Protein kinase, dual-specificity (non-receptor) P52564 5608 17q24.3 human T211-ac 4325702 LVDSVAKtIDAGCKP Pkinase enzymatic activity, inhibited; phosphorylation 16728640 2 0 0 yopJ inhibits MKK6 phosphorylation and its enzymatic activation in vitro -Tp53 p53 Activator; DNA-binding; Motility/polarity/chemotaxis; Nuclear receptor co-regulator; Transcription factor; Tumor suppressor P02340 22059 11 B3|11 42.83 cM mouse S58-p 2624500 EEFFEGPsEALRVSG apoptosis, inhibited; transcription, induced 16729035; 19118006 2 0 0 crucial for induction of transcription of p21, SESN2, Bbc3, and Bax; HIPK2 induced apoptosis is p53 dependent. -RRAGC RRAGC Q9HB90 64121 1p34.3 human S21-p 14579528 GSYGAADsFPKDFGY molecular association, regulation; phosphorylation cell growth, induced; autophagy, inhibited Raptor(INDUCES); mTOR(DISRUPTS) 30552228 1 7 0 induces Ulk1 and p70S6K phosphorylation, regulates mTORC1 raptor complex stability -RPS6KA3 RSK2 EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, AGC; Protein kinase, Ser/Thr (non-receptor) P51812 6197 Xp22.12 human S369-p 448064 TAKTPKDsPGIPPSA Pkinase_C protein conformation; enzymatic activity, induced transcription, induced 15657420; 17446865 10 51 20 -ABL1 Abl EC 2.7.10.2; KINASE; Kinase, protein; Oncoprotein; Protein kinase, TK; Protein kinase, tyrosine (non-receptor) P00519 25 9q34.12 human Y393-p 450298 RLMTGDTyTAHAGAK PK_Tyr_Ser-Thr enzymatic activity, induced cell cycle regulation; carcinogenesis, inhibited; apoptosis, induced; cell growth, inhibited; cell growth, altered 35569509; 36079767; 8441409 24 49 1642 -SPAG5 SPAG5 Cell cycle regulation Q96R06 10615 17q11.2 human S115-p 34824800 ISSTPKTsEEAVDPL activity, induced; molecular association, regulation cell cycle regulation; cell growth, altered Securin(INDUCES); CLASP1(INDUCES); SKAP55(INDUCES) 25009111 1 0 0 progression of mitosis; Separase activation -ERBB4 HER4 EC 2.7.10.1; KINASE; Kinase, protein; Membrane protein, integral; Protein kinase, TK; Protein kinase, tyrosine (receptor) Q15303 2066 2q34 human Y1022-p 36100601 DMMDAEEyLVPQAFN molecular association, regulation cell motility, induced CSK(INDUCES); VAV3(INDUCES); CRK(INDUCES) 16729043; 32561640 2 0 0 -Tp53 p53 Activator; DNA-binding; Motility/polarity/chemotaxis; Nuclear receptor co-regulator; Transcription factor; Tumor suppressor P02340 22059 11 B3|11 42.83 cM mouse K136-ac 1877365921 KLFCQLAkTCPVQLW P53 carcinogenesis, inhibited 33303641 1 0 0 -Prdx1 PRDX1 EC 1.11.1.15; Nuclear receptor co-regulator; Oxidoreductase P35700 18477 4 D1|4 53.28 cM mouse Y194-p 448924 DVNKSKEyFSKQK__ 1-cysPrx_C molecular association, regulation; enzymatic activity, inhibited carcinogenesis, induced LOX(DISRUPTS) 34389806 2 8 138 -IFITM3 IFITM3 Cell surface; Membrane protein, integral Q01628 10410 11p15.5 human Y20-p 463584 NSGQPPNyEMLKEEH activity, induced; ubiquitination; intracellular localization endocytosis, inhibited 23055554; 24627473; 26354436; 29263263 5 10 18 ubiquitination, decreased -PGR PR DNA-binding; Nuclear receptor; Transcription factor P06401 5241 11q22.1 human S345-p 450157 AFAPPRSsPCASSTP Prog_receptor molecular association, regulation transcription, induced SP1(INDUCES) 18202149; 8662865 6 1 0 -LDHA LDH-A Amino Acid Metabolism - cysteine and methionine; Apoptosis; Carbohydrate Metabolism - glycolysis and gluconeogenesis; Carbohydrate Metabolism - propanoate; Carbohydrate Metabolism - pyruvate; EC 1.1.1.27; Oxidoreductase P00338 3939 11p15.1 human S161-p 31882218 PKNRVIGsGCNLDSA protein stabilization; molecular association, regulation 14-3-3 epsilon(INDUCES) 36239424 1 4 0 inhibits nuclear ubiquitination/ polyubiquitination -DNAJC6 DNAJC6 Chaperone; EC 3.1.3.48; Motility/polarity/chemotaxis; PHOSPHATASE; Protein phosphatase, tyrosine (non-receptor) O75061 9829 1p31.3 human S570-p 2518108 SATSTSAsPTLRVGE molecular association, regulation CLTC(DISRUPTS) 29735704 2 15 6 -Tpt1 TPT1 Calcium-binding; Microtubule-binding P63029 116646 15q11 rat S9-p 40584901 IIYRDLIsHDELFSD TCTP intracellular localization 25854427 1 1 0 -BECN1 beclin 1 Adaptor/scaffold; Autophagy; Membrane protein, peripheral Q14457 8678 17q21.31 human K437-ub 41159602 KFMLTNLkWGLAWVS APG6 molecular association, regulation autophagy, induced PIK3C3(INDUCES) 23974797 1 0 0 -TIRAP TIRAP Adaptor/scaffold P58753 114609 11q24.2 human Y106-p 463809 AAQDLVSyLEGSTAS TIR_2 activity, induced; molecular association, regulation; phosphorylation transcription, induced; signaling pathway regulation TLR4(DISRUPTS); MYD88(DISRUPTS); Btk(INDUCES); P38A(INDUCES) 16439361; 18070880; 24840642; 35379857 4 0 1 TLR2/TLR4 signaling -SATB1 SATB1 DNA-binding; Transcription factor Q01826 6304 3p24.3 human K136-ac 464646 KGLIQVGkWNPVPLS ULD molecular association, regulation transcription, induced DNA(DISRUPTS) 16630892 1 0 0 Upregulates gene expression -CAV1 caveolin-1 Adaptor/scaffold; Motility/polarity/chemotaxis; Nuclear receptor co-regulator Q03135 857 7q31.2 human K26-ub 486921 REQGNIYkPNNKAMA molecular association, regulation; intracellular localization UBXN6(INDUCES); VCP(INDUCES) 23335559 1 8 6 CAV1 ubiquitylation and binding to the VCP-UBXD1 complex and sorting into lysosomes -FGF23 FGF23 Cytokine; Secreted; Secreted, signal peptide Q9GZV9 8074 12p13.32 human S180-p 33365504 IPRRHTRsAEDDSER protein degradation; O-GalNAc glycosylation 24706917 2 2 0 S180 phosphorylation inhibits T178 O-GalNAc glycosylation, promotes FGF23 cleavage -Lipe HSL EC 3.1.1.79; Lipase P54310 16890 7 A3|7 13.78 cM mouse S557-p 448803 PTESMRRsVSEAALA enzymatic activity, induced; phosphorylation signaling pathway regulation 19942859; 20332342; 30126894 41 11 2 Phosphorylation of HSL leads to lipolysis and browning of adipose tissue; inhibits phosphorylation at S559; Rictor/mTORC2 signaling in energy metabolism in fat cells -STK38 NDR1 EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, AGC; Protein kinase, Ser/Thr (non-receptor) Q15208 11329 6p21.31 human Y31-p 2526142 KVTLENFySNLIAQH molecular association, regulation; phosphorylation cytoskeletal reorganization MOB1A(INDUCES); MOB1B(NOT_REPORTED) 19836237 1 0 8 NDR1 Y31A and Y74A mutants showed highly decreased T444 phosphorylation and centrosome amplification. -FCRL4 FCRL4 Membrane protein, integral Q96PJ5 83417 1q23.1 human Y451-p 22730002 QVELQSLyVDVHPKK molecular association, regulation signaling pathway regulation Ig-alpha(INDUCES) 21908428; 25972488 2 0 0 all 3 sites (Y451, Y463, Y493) inhibits BCR signaling and enhances TLR9 signaling -NCF1 p47phox EC 1.-.-.-; Oxidoreductase P14598 653361 7q11.23 human S348-p 451728 PGPQSPGsPLEEERQ intracellular localization; enzymatic activity, induced carcinogenesis, induced; cell growth, induced 24632950 9 7 0 induces NOX1 activation and ROS generation -SLC6A2 SLC6A2 Membrane protein, integral; Membrane protein, multi-pass; Transporter; Transporter, SLC family P23975 6530 16q12.2 human T30-p 4957152 QPLRARKtAELLVVK intracellular localization endocytosis, inhibited 21498515; 28017803 2 0 0 transport, surface trafficking; reduced surface expression in T30A mutatnt -SIRPA SHPS1 Cell adhesion; Cell surface; Membrane protein, integral; Motility/polarity/chemotaxis; Receptor, misc. P78324 140885 20p13 human Y453-p 1861200 EPNNHTEyASIQTSP molecular association, regulation; phosphorylation cell motility, induced; cell growth, induced; signaling pathway regulation SHP-2(INDUCES); SHP-1(INDUCES) 10842184; 18233962; 21799000 4 2 5 regulation TLR3/4-dependent cytokine production pathway; induces phosphorylation of MAPK, regulates SHPS-1 signaling; Mutation of these 4 tyrosines does not affect JAK2 binding. However, overexpression of the WT SHPS1 but not the 4 tyrosine to phenylalanine mutation reduces tyrosine phosphorylation of Jak2, STAT5B, and STAT3 and activation of Erk1/2 in response to growth hormone. Does not affect STAT3 tyrosine phosphorylation in response to LIF agonist. -Ric8a RIC8A GEF; GEF, misc. NP_001093990 293614 1q41 rat S435-p 468627 GRPEGQYsEDEDTDT Ric8 activity, induced; protein stabilization; molecular association, regulation; protein conformation G-alpha i1(INDUCES) 29844055; 31155309; 31300652 2 58 64 G-alpha subunit guanine nucleotide exchange; G-alpha subunit folding; Phosphorylation at S435 and T440 augment stabilization of intramolecular electrostatic interactions in RIC8A; induces GEF activity -Mpl MPL Membrane protein, integral; Receptor, cytokine Q08351 17480 4 D2.1|4 54.61 cM mouse T569-p 3091408 LPKSSEStPLPLCPS activity, induced; phosphorylation cell growth, altered 10918061 1 0 0 tyrosine phosphorylation of JAK2 -APBB1 Fe65 Adaptor/scaffold; Apoptosis; Transcription regulation O00213 322 11p15.4 human T579-p 288031700 SSSREQWtPSHVSVA PID molecular association, regulation; intracellular localization; protein conformation APP(INDUCES) 28963516 1 0 0 promotes the amyloidogenic processing of APP; suppresses FE65-PTB2 dimerization; gamma-secretase cleavage of APP; cytoplasmic retention by enhancing FE65/APP interaction -AHR AHR DNA-binding; Transcription factor P35869 196 7p21.1 human T697-p 1874101926 EMDSMPYtQNFISCN protein degradation; ubiquitination autophagy, induced; transcription, induced 34198826 1 0 0 -IRF7 IRF7 DNA-binding; Transcription factor Q92985 3665 11p15.5 human K444-ub 4666607 DLSAGRPkEKSLVLV IRF-3 transcription, induced 18710948 1 0 0 -STX17 STX17 Membrane protein, integral; Membrane protein, multi-pass; Vesicle P56962 55014 9q31.1 human S289-p 4774791 MMEKLTSsCPDLPSQ molecular association, regulation; intracellular localization autophagy, induced FLNA(INDUCES) 37389864 1 16 5 -FERMT2 kindlin-2 Cytoskeletal; Motility/polarity/chemotaxis Q96AC1 10979 14q22.1 human K153-ub 1875153101 DPTKKKKkKLDDQSE protein degradation cell adhesion, inhibited 28408404 1 0 0 -APH1A APH1A Apoptosis; Endoplasmic reticulum; Membrane protein, integral; Membrane protein, multi-pass Q96BI3 51107 1q21.2 human S103-p 1877641902 KADEGLAsLSEDGRS Aph-1 molecular association, regulation; enzymatic activity, altered ARRB2(INDUCES) 35858570 1 1 0 -Yap1 YAP1 Oncoprotein; Transcription, coactivator/corepressor P46938 22601 9|9 A1 mouse S46-p 484116 VVHVRGDsETDLEAL intracellular localization carcinogenesis, induced; cell differentiation, induced; transcription, induced 33574090 13 47 1 -Mark1 MARK1 EC 2.7.11.1; EC 2.7.11.26; KINASE; Kinase, protein; Protein kinase, CAMK; Protein kinase, Ser/Thr (non-receptor) O08678 117016 13q26 rat S219-p 456805 KLDTFCGsPPYAAPE Pkinase enzymatic activity, induced 9108484 1 10 11 -Smo SMO Cell development/differentiation; GPCR, Fz/Smo family; Membrane protein, integral; Membrane protein, multi-pass; Oncoprotein; Receptor, GPCR P56726 319757 6 A3.3|6 12.36 cM mouse T597-p 1872776116 ELSFSMHtVSHDGPV molecular association, regulation transcription, induced PKACA(INDUCES) 33886552 1 1 0 -PARVA PARVA Adaptor/scaffold; Motility/polarity/chemotaxis Q9NVD7 55742 11p15.3 human S4-p 4270096 ____MATsPQKSPSV molecular association, regulation; enzymatic activity, induced cell motility, induced; cell adhesion, induced ARHGEF7(INDUCES); PAK1(INDUCES) 15353548; 22955285 2 7 0 Matrix degradation, Src and MMP2 activity -Smad7 SMAD7 DNA-binding; Transcription factor O35253 17131 18|18 E3 mouse S249-p 12559510 APGGLSDsQLLLEPG transcription, induced; transcription, inhibited 11278814 1 0 0 Smad7 activates or inhibits transcription depending on promoter context. S249 phosphorylation is important for both activation and inhibition. -MAPK14 P38A EC 2.7.11.24; KINASE; Kinase, protein; Protein kinase, CMGC; Protein kinase, Ser/Thr (non-receptor) Q16539 1432 6p21.31 human R149-me 1877038903 HSADIIHrDLKPSNL Pkinase molecular association, regulation; phosphorylation; enzymatic activity, induced cell differentiation, induced MAPKAPK2(INDUCES); MKK3(INDUCES) 32429593 1 1 0 augments phosphorylation by MKK3 and enhances the activation of p38-alpha -IRF3 IRF3 DNA-binding; Transcription factor Q14653 3661 19q13.33 human K98-ub 1877340002 RLAEDRSkDPHDPHK IRF transcription, induced DNA(INDUCES) 32075857 1 0 0 -NFKB1 NFkB-p105 DNA-binding; Transcription factor P19838 4790 4q24 human S923-p 447769 DELRDSDsVCDSGVE protein degradation 10469655 2 2 2 -ERBB2 HER2 EC 2.7.10.1; KINASE; Kinase, protein; Membrane protein, integral; Oncoprotein; Protein kinase, TK; Protein kinase, tyrosine (receptor) P04626 2064 17q12 human Y1005-p 458003 SPLDSTFyRSLLEDD molecular association, regulation SHC1(INDUCES) 16729043 1 5 75 -PAPOLA PAP-alpha EC 2.7.7.19; RNA processing; RNA splicing; Transferase P51003 10914 14q32.2 human K641-ac 483062 TSGNAATkIPTPIVG molecular association, regulation; intracellular localization CPSF6(DISRUPTS); CFIM25(DISRUPTS) 17172643 1 1 0 cytoplasmic localization -Anxa2 ANXA2 Calcium-binding; Lipid-binding; Motility/polarity/chemotaxis P07356 12306 9 C|9 38.58 cM mouse Y24-p 449483 HSTPPSAyGSVKPYT molecular association, regulation; intracellular localization; activity, inhibited cell adhesion, induced; cytoskeletal reorganization; endocytosis, inhibited NKCC2(INDUCES); OMP(INDUCES) 21737841; 24526686; 24742684; 25775977; 32442363; 34684255 29 64 2613 -Gria1 GluR1 Channel, calcium; Channel, ligand-gated; Membrane protein, integral; Membrane protein, multi-pass P23818 14799 11 B1.3|11 34.51 cM mouse S849-p 448565 FCLIPQQsINEAIRT activity, induced; molecular association, regulation; receptor desensitization, altered; intracellular localization; receptor internalization, altered; receptor recycling, altered; phosphorylation neural plasticity; signaling pathway regulation NMDAR1(INDUCES) 12628184; 17360685; 17689977; 17880895; 17923095; 18455244; 21483826; 21516102; 24038144; 33526688 94 4 3 -Ppargc1b PGC-1 beta Nuclear receptor co-regulator; Transcription, coactivator/corepressor Q8VHJ7 170826 18|18 E1 mouse K726-ac 7761204 APLPTETkAPRREAN intracellular localization transcription, inhibited 19491097 1 1 0 -DNM2 DYN2 EC 3.6.5.5; Hydrolase; Microtubule-binding; Motility/polarity/chemotaxis; Vesicle P50570 1785 19p13.2 human S764-p 3191449 LQSASSHsPTPQRRP molecular association, regulation; intracellular localization cell cycle regulation 20889493; 21195118 5 9 0 important for cytokinesis; reduces microtubule-binding activity of DYN2 -SP1 SP1 C2H2-type zinc finger protein; DNA-binding; Transcription factor P08047 6667 12q13.13 human T278-p 1988302 SVSAATLtPSSQAVT molecular association, regulation; protein stabilization cell differentiation, inhibited; cell cycle regulation; cell growth, induced; transcription, induced; transcription, inhibited DNA(DISRUPTS) 18199680; 19245816; 32205409 4 0 0 regulates cell proliferation; protects from ubiquitin-dependent degradation during mitosis; during mitosis; reduces binding to FBXL2 promoter -SKAP1 SKAP55 Adaptor/scaffold; Motility/polarity/chemotaxis Q86WV1 8631 17q21.32 human Y232-p 451308 EEEKEETyDDIDGFD molecular association, regulation; intracellular localization; phosphorylation transcription, induced CD45(INDUCES) 11909961 1 0 1 -WWC1 KIBRA Adaptor/scaffold Q8IX03 23286 5q34 human S947-p 453630 CRLNRSDsDSSTLSK cell motility, induced; cell growth, induced 24269383 1 18 46 -VGLL4 VGLL4 iso4 Transcription, coactivator/corepressor Q14135-4 9686 3p25.3-p25.2 human S280-p 458220 SRRGQPAsPSAHMVS cell cycle regulation; cell growth, induced 28739871 1 14 53 Mitotic phosphorylation -MAP3K3 MEKK3 EC 2.7.11.25; KINASE; Kinase, protein; Protein kinase, STE; Protein kinase, Ser/Thr (non-receptor) Q99759 4215 17q23.3 human T516-p 12607405 GASKRLQtICMSGTG Pkinase enzymatic activity, induced 20068038 2 0 0 essential for MEKK3-mediated IKK-beta/NFkB activation -Aatk Lmr1 iso2 EC 2.7.11.1; KINASE; Kinase, protein; Membrane protein, integral; Protein kinase, Ser/Thr (non-receptor); Protein kinase, TK; Protein kinase, tyrosine (receptor) Q80YE4-2 11302 11|11 E2 mouse S34-p 14364500 ADFSEQGsPAAAAQT molecular association, regulation; intracellular localization; phosphorylation cell growth, inhibited; cytoskeletal reorganization RAB11A(DISRUPTS) 20422042; 20553326; 22573681; 24672056 4 0 0 Regulates RAB11A activity; influences transferrin uptake and recycling; inhibits tyrosine phosphorylation of Lmr1; decreased dendritic arborization -RASAL2 RASAL2 iso2 GAP; GAP, Ras Q9UJF2-2 9462 1q25.2 human S237-p 468582 PKLKESRsHESLLSP carcinogenesis, induced 31759919 1 14 0 -IL16 IL16 Cytokine; DNA-binding; Motility/polarity/chemotaxis Q14005 3603 15q25.1 human S743-p 11280302 MPLQPNAsLNEEEGT intracellular localization cell cycle regulation 12450396 1 1 0 regulate nuclear localization -Cdk1 CDK1 Cell cycle regulation; EC 2.7.11.22; EC 2.7.11.23; KINASE; Kinase, protein; Motility/polarity/chemotaxis; Protein kinase, CMGC; Protein kinase, Ser/Thr (non-receptor) P11440 12534 10 B5.3|10 36.07 cM mouse T161-p 447609 GIPIRVYtHEVVTLW Pkinase phosphorylation; enzymatic activity, induced cell cycle regulation; carcinogenesis, induced; carcinogenesis, altered; apoptosis, inhibited; cell growth, altered 33761914; 35508654; 35694267 44 43 83 induces Rb phosphorylation -Cdkn1c p57Kip2 Cell cycle regulation; Inhibitor; Nuclear receptor co-regulator; Tumor suppressor P49919 12577 7 F5|7 88.22 cM mouse S19-p 22354700 TAMERLAsSDTFPVI protein degradation; ubiquitination cell cycle regulation; apoptosis, inhibited; transcription, inhibited 21791608 1 1 0 -CTNNB1 CTNNB1 Actin-binding; Cell adhesion; Motility/polarity/chemotaxis; Nuclear receptor co-regulator; Oncoprotein; Transcription factor P35222 1499 3p22.1 human K49-ac 458938 TAPSLSGkGNPEEED acetylation; molecular association, regulation; protein stabilization; ubiquitination; intracellular localization; phosphorylation carcinogenesis, induced; carcinogenesis, inhibited; cell motility, induced; transcription, induced; cell differentiation, induced; cell growth, induced; apoptosis, inhibited; transcription, inhibited LEF-1(INDUCES); HDAC7(INDUCES); Bcl-3(INDUCES) 18356165; 18987336; 21952047; 23727580; 25546293; 26477307; 28329675; 30691485; 31930681; 32355204; 32581357; 35277183; 35494070 17 0 0 higher intracellular pH leads to activation of mesodermal transcriptional WNT targets; HDAC7 expresssion promotes ?-catenin nuclear import, Wnt pathway target gene protein expression were downregulated; CK1d/CK1?/beta-catenin/Tip60 complexes are in colon cancer cells, treatment with CK1 or Tip60 inhibitors downregulate the level of beta-catenin acetylation and inhibit viability and proliferation of colon cancer cells, transcription of Wnt target genes ; high level of Ac-K49 beta-catenin to promote Wnt/?-catenin activity; promotes nuclear translocation, inhibits phosphorylation and ubiquitination -RELA NFkB-p65 DNA-binding; Nuclear receptor co-regulator; Transcription factor Q04206 5970 11q13.1 human T435-p 451422 PTQAGEGtLSEALLQ transcription, inhibited 20001970 2 0 0 -GATA6 GATA6 Motility/polarity/chemotaxis; Transcription factor Q92908 2627 18q11.2 human S37-p 15419868 REPSTPPsPISSSSS protein degradation transcription, induced 27273097 1 4 5 alleviates GATA6 repression of transcription -DGCR8 DGCR8 Nucleolus; RNA processing; RNA-binding Q8WYQ5 54487 22q11.21 human S383-p 31864184 VSPVKPLsRSAELEF protein stabilization 24239349 0 3 0 -NFATC1 NFAT2 DNA-binding; Transcription factor O95644 4772 18q23 human S187-p 465578 RSCNSEAsSYESNYS intracellular localization 10652349 1 0 1 cooperates with S172 to induce nuclear localization of NFAT2 -Ptk2 FAK EC 2.7.10.2; KINASE; Kinase, protein; Protein kinase, TK; Protein kinase, tyrosine (non-receptor) O35346 25614 7q34 rat S913-p 447964 RLQPQEIsPPPTANL molecular association, regulation; intracellular localization 12732587; 16373587 20 48 0 -VASP VASP Cytoskeletal; Motility/polarity/chemotaxis P50552 7408 19q13.32 human T278-p 448381 LARRRKAtQVGEKTP carcinogenesis, altered; cell motility, altered; cytoskeletal reorganization; transcription, inhibited 14679200; 17082196; 18637808; 21423205 11 3 19 -IRS1 IRS1 Adaptor/scaffold; Motility/polarity/chemotaxis P35568 3667 2q36.3 human Y612-p 447555 TLHTDDGyMPMSPGV activity, induced; molecular association, regulation cell differentiation, induced; transcription, induced PIK3R1(INDUCES) 11416002; 12525499; 22081023 33 12 294 -Oprm1 MOR-1 GPCR, family 1; Membrane protein, integral; Membrane protein, multi-pass; Receptor, GPCR P33535 25601 1q11 rat T394-p 448128 LENLEAEtAPLP___ receptor desensitization, altered; receptor internalization, altered 10820022; 12860981; 9312100 5 0 0 -PTHLH PTHrP Secreted; Secreted, signal peptide P12272 5744 12p11.22 human T121-p 449879 YKEQPLKtPGKKKKG Parathyroid molecular association, regulation; intracellular localization KPNB1(DISRUPTS) 10373465; 12504010 2 0 0 decreases nuclear accumulation; T121E mutation was localized in the cytoplasm, while a T121A mutation showed nuclear localization. -SKI SKI Cell cycle regulation; Oncoprotein; Transcription, coactivator/corepressor; Ubiquitin conjugating system P12755 6497 1p36.33-p36.32 human S383-p 11145003 LSAFRPWsPAVSASE protein degradation cell cycle regulation; carcinogenesis, induced 26138431 3 10 7 plays a role in chromosomal segregation -Ikbkg IKKG Adaptor/scaffold; Protein kinase, regulatory subunit O88522 16151 X|X A7.3 mouse S375-p 449755 HSFHLALsNQRRSPP activity, inhibited transcription, altered 11971901 1 0 0 NFKB reporter assays -MAP4K1 HPK1 EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, STE; Protein kinase, Ser/Thr (non-receptor) Q92918 11184 19q13.2 human T355-p 23113939 ETRPPANtARLQPPR ubiquitination 24362026 1 0 6 -EHMT2 EHMT2 Amino Acid Metabolism - lysine degradation; EC 2.1.1.43; METHYLTRANSFERASE; Methyltransferase; Methyltransferase, protein lysine Q96KQ7 10919 6p21.33 human K288-sm 1878097301 ERVDSDSkSEVEALT molecular association, regulation; intracellular localization cell cycle regulation; cell growth, induced; transcription, induced PCAF(INDUCES) 30867409 1 0 0 SUMOylated G9a is recruited to E2F1 target gene promoters, EHMT2 is an activator of proliferation and E2F1-target gene expression -TRPC5 TRPC5 Channel, cation; Membrane protein, integral; Membrane protein, multi-pass Q9UL62 7224 Xq23 human S794-p 20834807 SGGARAKsKSVSFNL intracellular localization; activity, inhibited signaling pathway regulation 21734191 1 0 0 -MYH7 MYH7 Motility/polarity/chemotaxis; Motor P12883 4625 14q11.2 human K1195-ac 36314472 TAAALRKkHADSVAE Myosin_tail_1 protein conformation 35502901 0 2 0 -RPS3 RPS3 Apoptosis; EC 4.2.99.18; RNA-binding; Ribosomal; Translation P23396 6188 11q13.4 human S6-p 8046503 __MAVQIsKKRKFVA activity, induced; intracellular localization translation, altered 19059439 2 0 0 important for a cell survival in the stress condition -SNAI1 Snail1 C2H2-type zinc finger protein; Transcription factor O95863 6615 20q13.13 human S112-gl 18416103 PPSPAPSsFSSTSVS protein stabilization; phosphorylation cell motility, induced; transcription, inhibited 20959806 1 1 0 transcriptional suppression of E-cadherin; inhibits O-phosphorylation; induces cell migration and in vivo invasion -TTK TTK Cancer Testis Antigen (CTA); EC 2.7.12.1; KINASE; Kinase, protein; Protein kinase, Other; Protein kinase, dual-specificity (non-receptor) P33981 7272 6q14.1 human T288-p 6370307 SPDCDVKtDDSVVPC protein stabilization; intracellular localization; phosphorylation cell cycle regulation HEC1(INDUCES) 19151762; 24764296; 24798733 4 1 0 -ATG13 ATG13 Autophagy; Vesicle O75143 9776 11p11.2 human S355-p 21127300 DTETVSNsSEGRASP intracellular localization carcinogenesis, altered; autophagy, induced; autophagy, inhibited; signaling pathway regulation 21855797; 24590173; 27259258; 34586834 18 5 0 -Ddx1 DDX1 EC 3.6.4.13; Helicase; RNA-binding Q641Y8 84474 6q15 rat S295-p 1275585100 KALIVEPsRELAEQT DEAD molecular association, regulation RNA(INDUCES) 30295850 1 1 0 insulin translation inhibited -AATF AATF Nucleolus; RNA-binding; Transcription factor Q9NY61 26574 17q12 human S510-p 3753302 KKVDRKAsKGRKLRF TRAUB protein stabilization; molecular association, regulation apoptosis, inhibited; transcription, altered NFkB-p65(INDUCES) DNA(INDUCES) 17157788 1 0 0 -Fus hnRNP P2 DNA-binding; Nuclear receptor co-regulator; Oncoprotein; RNA splicing; RNA-binding; SUMO LIGASE P56959 233908 7|7 F3 mouse Y518-p 50318713 QDRRERPy_______ intracellular localization 37071594 2 0 0 -Ikbkb IKKB EC 2.7.11.10; KINASE; Kinase, protein; Protein kinase, Other; Protein kinase, Ser/Thr (non-receptor) O88351 16150 8|8 A2 mouse S181-p 447489 DQGSLCTsFVGTLQY Pkinase activity, induced; molecular association, regulation; intracellular localization; phosphorylation; enzymatic activity, induced apoptosis, altered; cell differentiation, induced; transcription, induced PPP2R3C(INDUCES) 18497757; 20534585; 20925653; 23332762; 36309088; 36896602; 36914767 76 2 0 induces NFKB phosphorylation; induces IkBa degradation -Trhr TRHR GPCR, family 1; Membrane protein, integral; Membrane protein, multi-pass; Receptor, GPCR Q01717 25570 7q31 rat S360-p 1229701 NYSVIKEsDRFSTEL receptor internalization, altered 17989235; 20345371 3 0 0 -Hmgcr HMGCR EC 1.1.1.34; Endoplasmic reticulum; Membrane protein, integral; Membrane protein, multi-pass; Motility/polarity/chemotaxis; Oxidoreductase; Secondary Metabolites Metabolism - terpenoid backbone biosynthesis Q01237 15357 13 D1|13 50.65 cM mouse K89-ub 55607400 NLRQLGSkYILGIAG Sterol-sensing protein degradation 27129778 2 0 0 -Pacsin1 PACSIN1 Adaptor/scaffold Q61644 23969 17|17 A3.3 mouse S76-p 23940709 EKGPQYGsLERAWGA FCH protein conformation 22355135 1 2 0 -PARP10 PARP10 EC 2.4.2.30; Nucleolus; Transferase Q53GL7 84875 8q24.3 human T101-p 12526705 QGLPPGTtPQRLEQH molecular association, regulation; intracellular localization transcription, altered; cell growth, altered POLR2A(INDUCES) 16455663 1 0 0 PARP10 T101 phosphorylation is associated with actively growing cells. -IGFBP3 IGFBP3 Cell development/differentiation; Secreted; Secreted, signal peptide P17936 3486 7p12.3 human S183-p 471397 KKGHAKDsQRYKVDY intracellular localization apoptosis, altered; cell growth, induced; apoptosis, inhibited 17108124; 23557743 2 0 0 -UBE2I UBC9 EC 6.3.2.-; EC 6.3.2.19; Ligase; Nuclear receptor co-regulator; SUMO LIGASE; SUMO conjugating system; SUMO ligase; UBIQUITIN LIGASE; Ubiquitin conjugating system; Ubiquitin ligase P63279 7329 16p13.3 human S71-p 3803343 FKDDYPSsPPKCKFE UQ_con molecular association, regulation; protein stabilization; enzymatic activity, induced PLK1(INDUCES) 22407595; 22509284; 29166606 4 6 8 -FLOT1 FLOT1 Adaptor/scaffold O75955 10211 6p21.33 human S315-p 18750500 QAEAEAAsVRMRGEA intracellular localization; protein conformation endocytosis, induced; cell motility, inhibited 21399631; 31753918 2 0 0 decrease angiogenesis -Prkcd PKCD EC 2.7.11.13; KINASE; Kinase, protein; Nuclear receptor co-regulator; Protein kinase, AGC; Protein kinase, Ser/Thr (non-receptor); Protein kinase, tyrosine (non-receptor); Tumor suppressor P09215 170538 16p16 rat Y64-p 447581 STFDAHIyEGRVIQI intracellular localization apoptosis, induced 24569990 7 3 31 -STK4 MST1 Autophagy; EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, STE; Protein kinase, Ser/Thr (non-receptor) Q13043 6789 20q13.12 human T120-p 11496001 IIRLRNKtLTEDEIA Pkinase molecular association, regulation; intracellular localization; enzymatic activity, inhibited; phosphorylation carcinogenesis, induced; apoptosis, altered; cell growth, induced; transcription, induced; signaling pathway regulation AR(DISRUPTS) 19940129; 22619175 3 0 0 regulates autophosphorylation of MST1 T183; Hippo signaling pathway -Pth1r PTHR GPCR, family 2; Membrane protein, integral; Membrane protein, multi-pass; Receptor, GPCR P25961 56813 8q32 rat S493-p 2853105 KARSGSSsYSYGPMV receptor internalization, altered; activity, inhibited 11773434; 18577695 4 2 0 -SLC14A2 SLC14A2 Membrane protein, integral; Membrane protein, multi-pass; Transporter; Transporter, SLC family Q15849 8170 18q12.3 human S490-p 2813500 WSSIRRRsKVFGKGE ubiquitination 24133116 6 0 0 mutant reduces forskolin induced SLC14AZ ubiquitination -CDC7 CDC7 EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, Other; Protein kinase, Ser/Thr (non-receptor) O00311 8317 1p22.2-p22.1 human T503-p 23092189 KASCLVQtPPGQYSG protein degradation; ubiquitination 27611229 1 7 2 -NUP98 NUP98 iso2 Motility/polarity/chemotaxis; Nucleoporin P52948-2 4928 11p15.4 human S568-p 18330802 GLDDDEPsLANGAFM intracellular localization 21335236 1 1 0 as multiple sites (13PM) mutant -MDC1 MDC1 Cell cycle regulation Q14676 9656 6p21.33 human K1977-ub 25091200 VTDPEQEkNFGFSLQ molecular association, regulation; intracellular localization DNA repair, induced RAP80(INDUCES) 21857162 1 0 0 focus formation of RAP80-BRCA1 complex to DSBs for repair -ENSA ENSA Inhibitor; Protein phosphatase, regulatory subunit O43768 2029 1q21.3 human S67-p 455934 KGQKYFDsGDYNMAK Endosulfine molecular association, regulation; enzymatic activity, inhibited cell cycle regulation PPP2CA(INDUCES) 24391510; 27889260; 32085646 5 68 47 -TBXA2R TXA2-R iso2 GPCR, family 1; Membrane protein, integral; Membrane protein, multi-pass; Receptor, GPCR P21731-2 6915 19p13.3 human T332-p 18790000 TRPRRSLtLWPSLEY receptor desensitization, altered 14530262 1 0 0 -RHOA RHOA G protein; G protein, monomeric; G protein, monomeric, Rho; Motility/polarity/chemotaxis; Oncoprotein P61586 387 3p21.31 human S88-p 53332703 LMCFSIDsPDSLENI Ras activity, induced; intracellular localization cytoskeletal reorganization ROCK1(INDUCES) 26816343 1 0 0 enhanced actin stress fiber formation, distributed in the cytoplasm with or without EGF stimulation -KAT5 Tip60 ACETYLTRANSFERASE; Acetyltransferase; EC 2.3.1.48; Nuclear receptor co-regulator; Nucleolus Q92993 10524 11q13.1 human S86-p 448826 TKNGLPGsRPGSPER activity, induced; acetylation; protein stabilization DNA repair, induced; apoptosis, induced; transcription, induced; transcription, altered 16103124; 21658600; 30297459; 30704899 7 31 5 -STIM1 STIM1 Calcium-binding; Endoplasmic reticulum; Membrane protein, integral Q13586 6786 11p15.4 human S575-p 468876 LVEKLPDsPALAKKA molecular association, regulation; intracellular localization; activity, inhibited; protein conformation cell motility, induced EB1(DISRUPTS); CDON(INDUCES) 22298426; 25447552; 25562429; 28935720 9 69 13 GPER activation to inhibit SOCE; promotes myoblast differentiation; accelerates cell migration in wound-healing assays; NFAT translocation to the nucleus, multimerization -FCER1G FCER1G Membrane protein, integral; Receptor, misc. P30273 2207 1q23.3 human Y65-p 451737 YEKSDGVyTGLSTRN ITAM phosphorylation 27630214 4 15 593 S69 phosphorylation inhibits Y65 phosphorylation -TRPC6 TRPC6 Channel, cation; Membrane protein, integral; Membrane protein, multi-pass Q9Y210 7225 11q22.1 human T70-p 470868 RLAHRRQtVLREKGR activity, inhibited cell motility, inhibited 19961855; 23814119; 24740790 11 2 6 -POLH POLH DNA repair, damage; EC 2.7.7.7; Transferase Q9Y253 5429 6p21.1 human T617-p 5024700 SKSVLEVtQKATPNP intracellular localization DNA repair, induced; cell growth, altered 18946034; 35339488 2 0 0 -JUND JunD Motility/polarity/chemotaxis; Transcription factor P17535 3727 19p13.11 human S100-p 456168 LGLLKLAsPELERLI Jun molecular association, regulation transcription, induced MEN1(DISRUPTS) 22327296 5 63 12 -RGS18 RGS18 GAP; GAP, RGS Q9NS28 64407 1q31.2 human S216-p 4772683 PTNLRRRsRSFTCNE molecular association, regulation signaling pathway regulation 14-3-3 gamma(DISRUPTS) 22234696; 24244663 2 4 0 inhibits RGS18 binding to 14-3-3 gamma via S49; Ca 2+ signaling; constitutive binding to 14-3-3 gamma; followed by dephosphorylation of S49 and S218 -Tnfaip3 TNFAIP3 Apoptosis; DEUBIQUITINASE; EC 3.4.19.12; Protease; UBIQUITIN LIGASE; Ubiquitin conjugating system; Ubiquitin ligase Q60769 21929 10 A3|10 8.08 cM mouse S381-p 487535 EPSTPQLsLMDIKCE molecular association, regulation; intracellular localization TNIP1(INDUCES) 29203883 5 10 0 recruitment into TNF-RSC -MLYCD MLYCD Carbohydrate Metabolism - propanoate; EC 4.1.1.9; Lyase; Other Amino Acids Metabolism - beta-alanine O95822 23417 16q23.3 human S204-p 41196500 LERVTWHsPCEVLQK MCD protein conformation; enzymatic activity, induced 26004805 1 0 0 -MAST1 MAST1 EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, AGC; Protein kinase, Ser/Thr (non-receptor) Q9Y2H9 22983 19p13.13 human K317-ub 964526012 AKEGHLVkTDIPRYI DUF1908 protein degradation 31449053 1 2 0 proteasomal degradation sensitizes cisplatin-resistant cells to cisplatin -FOXA2 FOXA2 DNA-binding; Transcription factor Q9Y261 3170 20p11.21 human S107-p 22825100 AGMGPHLsPSLSPLG Forkhead_N carcinogenesis, induced; cell growth, induced; transcription, inhibited; signaling pathway regulation 22196886 1 1 0 -FLT3 FLT3 EC 2.7.10.1; KINASE; Kinase, protein; Membrane protein, integral; Oncoprotein; Protein kinase, TK; Protein kinase, tyrosine (receptor) P36888 2322 13q12.2 human Y591-p 448190 SSDNEYFyVDFREYE molecular association, regulation; enzymatic activity, induced; phosphorylation cell growth, altered Fyn(INDUCES) 11971190; 16103085; 16627759; 26848862 14 0 0 The double mutation Y589/591F has a slower growth rate (this is in the ligand-independent, constitutive active allele). -Mc2r MC2R GPCR, family 1; Membrane protein, integral; Membrane protein, multi-pass; Receptor, GPCR Q64326 17200 18 E2|18 41.89 cM mouse S208-p 456021 RSHARKIsTLPRTNM 7tm_1 receptor desensitization, altered 12456795 1 0 0 -UBE2I UBC9 EC 6.3.2.-; EC 6.3.2.19; Ligase; Nuclear receptor co-regulator; SUMO LIGASE; SUMO conjugating system; SUMO ligase; UBIQUITIN LIGASE; Ubiquitin conjugating system; Ubiquitin ligase P63279 7329 16p13.3 human K65-ac 11316163 FKLRMLFkDDYPSSP UQ_con sumoylation; molecular association, regulation; protein conformation CAPN2(DISRUPTS); CBP(DISRUPTS); ELK1(DISRUPTS) 23395904; 29234076 2 5 0 disruption of the binding affinity of Ubc9 to NDSM residues, such as in Calpain2, Elk1, and CBP, but not with non-NDSM -Glp1r GLP1R GPCR, family 2; Membrane protein, integral; Membrane protein, multi-pass; Receptor, GPCR P32301 25051 20p12 rat S432-p 451367 LNIQRDSsMKPLKCP receptor desensitization, altered 8702711 1 0 0 -LEO1 LEO1 Transcription regulation Q8WVC0 123169 15q21.2 human S88-p 83111281 SERSDNRsEASERSD molecular association, regulation; intracellular localization carcinogenesis, inhibited; cell growth, inhibited; apoptosis, induced; transcription, inhibited; signaling pathway regulation CTNNB1(DISRUPTS) 30305722 1 2 0 -Cdkn1b p27Kip1 Cell cycle regulation; Inhibitor; Oncoprotein; Protein kinase, regulatory subunit P46414 12576 6 G1|6 65.77 cM mouse T183-p 23128659 DGSPNAGtVEQTPKK intracellular localization carcinogenesis, induced; cell growth, induced 23602409 1 1 1 -Homer2 HOMER2 Actin-binding; Adaptor/scaffold Q9QWW1 26557 7|7 D3 mouse S117-p 3893303 ARLARDKsQEKTETS molecular association, regulation mGluR5(DISRUPTS) 36973011 1 0 6 -MAPRE3 EB3 Microtubule-binding Q9UPY8 22924 2p23.3 human S162-p 2023813 TAVPQRTsPTGPKNM molecular association, regulation; protein conformation cell adhesion, induced; cytoskeletal reorganization PPP3CA(DISRUPTS) 23159740 1 24 1 inhibits persistent microtubule growth and supports adherens junctions integrity; destabilizes EB3 dimers -Relb RELB Transcription factor Q04863 19698 7 A3|7 9.93 cM mouse K308-ub 3055602 LLCDKVQkEDISVVF RHD_dimer transcription, induced 18620544 1 0 0 -Dcc DCC Immunoglobulin superfamily; Membrane protein, integral; Receptor, misc.; Tumor suppressor Q63155 25311 18q12.1 rat Y1418-p 454409 TEDPASVyEQDDLSE Neogenin_C cell growth, altered 15557120; 18253061 5 0 0 -Gjd2 GJD2 Cell adhesion; Channel, misc.; Membrane protein, integral; Membrane protein, multi-pass O54851 14617 2|2 E4 mouse S293-p 471387 GAQAKRKsVYEIRNK activity, induced; activity, inhibited neural plasticity 16956882; 32547367 4 3 0 adaptation to ambient light conditions; induces coupling through gap junctions; regulating gap junction communication -NCOA1 SRC-1 ACETYLTRANSFERASE; Acetyltransferase; DNA-binding; EC 2.3.1.48; Nuclear receptor co-regulator; Oncoprotein; Transcription, coactivator/corepressor Q15788 8648 2p23.3 human T1426-p 18958502 KPTSGPQtPQAQQKS transcription, induced 21550420 1 0 0 -ZNF281 ZNF281 C2H2-type zinc finger protein; DNA-binding; Transcription factor Q9Y2X9 23528 1q32.1 human S638-p 31881319 PRVDLHTsGEHSELV protein degradation; ubiquitination FBW1B(INDUCES) 29179460 1 1 0 -NHE-3 NHE3 Membrane protein, integral; Membrane protein, multi-pass; Transporter; Transporter, SLC family P26432 100009430 rabbit S719-p 3496800 KERELELsDPEEAPD activity, induced; molecular association, regulation; intracellular localization; activity, inhibited SNX27(INDUCES) 18614797; 28495796 3 3 0 -Nr3c1 GR DNA-binding; Mitochondrial; Nuclear receptor; Transcription factor P06536 24413 18p11 rat S246-p 451796 LIDENLLsPLAGEDD GCR activity, induced; activity, inhibited transcription, induced; transcription, altered 11139390; 15292225; 18304804; 18337589; 9482836 39 9 1 modulates sumoylation at K297 and K313; Inhibitory of GR mediated transcription by JNK was weak consistent with earlier data that the inhibitory effect of JNK is atributable to S246 phosphorylation, which is not present in the GR525-795 construct. ; induces hormone-dependent recruitment of GR to promoters (of tat, sult and gliz genes) -NIN NIN Cytoskeletal; Microtubule-binding Q8N4C6 51199 14q22.1 human K1680-sm 12004429 QQENHLLkDELEKMK intracellular localization 16154161 1 0 0 -TP63 p63 DNA-binding; Transcription factor Q9H3D4 8626 3q28 human S43-p 27937107 YRSTMSQsTQTNEFL molecular association, regulation transcription, inhibited p300(DISRUPTS) 23589370 1 1 0 -SUV39H1 SUV39H1 Amino Acid Metabolism - lysine degradation; EC 2.1.1.43; METHYLTRANSFERASE; Methyltransferase; Methyltransferase, protein lysine O43463 6839 Xp11.23 human K266-ac 1876066700 RTLEKIRkNSFVMEY SET enzymatic activity, inhibited transcription, inhibited 18004385 1 0 0 -HOXA10 HOXA10 DNA-binding; Transcription factor P31260 3206 7p15.2 human K339-ac 31094515 TAKSGRKkRCPYTKH Homeodomain protein degradation transcription, inhibited; cell adhesion, inhibited 24037888 1 0 0 -FLT3 FLT3 EC 2.7.10.1; KINASE; Kinase, protein; Membrane protein, integral; Oncoprotein; Protein kinase, TK; Protein kinase, tyrosine (receptor) P36888 2322 13q12.2 human Y793-p 7996202 EDLLCFAyQVAKGME PK_Tyr_Ser-Thr molecular association, regulation GRB10(INDUCES) 23246379 2 0 1 -Aurka AurA EC 2.7.11.1; KINASE; Kinase, protein; Oncoprotein; Protein kinase, Other; Protein kinase, Ser/Thr (non-receptor) P97477 20878 2 H3|2 94.84 cM mouse T279-p 448784 APSSRRTtMCGTLDY Pkinase intracellular localization; phosphorylation; enzymatic activity, induced neural plasticity; carcinogenesis, induced; chromatin organization, altered; transcription, induced; signaling pathway regulation 18677115; 33439240; 34031150; 34772938; 35771632 66 12 7 -Gap43 GAP43 Cell surface P06837 14432 16 B4|16 28.37 cM mouse T172-p 449106 VTDAAATtPAAEDAA Neuromodulin cell growth, induced; cytoskeletal reorganization 33832520 2 16 3 -Gphn gephyrin Adaptor/scaffold; EC 2.10.1.1; EC 2.7.7.75 Q8BUV3 268566 12|12 C3 mouse S194-p 478375 PSPPPPLsPPPTTSP molecular association, regulation PIN1(INDUCES) 17347650 3 45 0 -Polr2a POLR2A EC 2.7.7.48; EC 2.7.7.6; Nucleotide Metabolism - purine; Nucleotide Metabolism - pyrimidine; Transcription initiation complex; Transferase P08775 20020 11 B3|11 42.86 cM mouse K1887-ub 2134722 TYSPTTPkYSPTSPT protein degradation 17526739 1 1 0 -Foxg1 FOXG1 DNA-binding; Nuclear receptor co-regulator; Transcription factor Q60987 15228 12 B3|12 21.78 cM mouse T271-p 482881 KLRRRSTtSRAKLAF intracellular localization apoptosis, inhibited; transcription, induced 21228151; 26523971 3 0 0 -ING1 ING1 iso2 Tumor suppressor Q9UK53-2 3621 13q34 human S199-p 18010889 AKAEREAsPADLPID sumoylation 24903338 1 2 0 S199-p promotes SUMOylation of K193 -RUNX3 AML2 DNA-binding; Transcription factor Q13761 864 1p36.11 human T155-p 6097703 KSFTLTItVFTNPTQ Runt protein stabilization; intracellular localization cell cycle regulation; transcription, altered 18767071 1 1 0 -Kcnb2 Kv2.2 Channel, potassium; Membrane protein, integral; Membrane protein, multi-pass Q63099 117105 5q11 rat S481-p 15720997 ESANIKDsVDDNHLS Kv2channel activity, inhibited neural plasticity 34542799 1 2 0 -PDGFRB PDGFRB EC 2.7.10.1; KINASE; Kinase, protein; Membrane protein, integral; Oncoprotein; Protein kinase, TK; Protein kinase, tyrosine (receptor) P09619 5159 5q32 human S712-p 23130549 SDKRRPPsAELYSNA PK_Tyr_Ser-Thr enzymatic activity, inhibited; phosphorylation signaling pathway regulation 29935031 1 1 2 regulates MEK/ERK and PI3K/AKT mediated pathways, inhibits phosphorylation of Y751 -RCC1 RCC1 Cell cycle regulation; GEF; GEF, Ras P18754 1104 1p35.3 human S29-p 2850004 KVKVSHRsHSTEPGL molecular association, regulation KPNA4(DISRUPTS) 18568422 1 0 0 -Foxo1 FOXO1A DNA-binding; Nuclear receptor co-regulator; Oncoprotein; Transcription factor G3V7R4 84482 2q26 rat S313-p 449113 TFRPRTSsNASTISG molecular association, regulation; acetylation; intracellular localization transcription, induced DNA(DISRUPTS) 33560565 29 5 27 H4 acetylation -PPP1R2 PPP1R2 Inhibitor; Motility/polarity/chemotaxis; Protein phosphatase, regulatory subunit P41236 5504 3q29 human S44-p 2231000 DEELSKKsQKWDEMN cell cycle regulation PPP1CA(DISRUPTS) 18250156 2 0 0 in response to IR-induced DNA damage -TNK2 Ack EC 2.7.10.2; EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, TK; Protein kinase, tyrosine (non-receptor) Q07912 10188 3q29 human Y860-p 448884 KVSSTHYyLLPERPS protein conformation; phosphorylation; enzymatic activity, induced 36178070 3 19 222 -CFTR CFTR Channel, chloride; EC 3.6.3.49; Hydrolase; Membrane protein, integral; Membrane protein, multi-pass; Transporter; Transporter, ABC family P13569 1080 7q31.2 human T682-p 2907505 APVSWTEtKKQSFKQ CFTR_R activity, induced; protein conformation; activity, inhibited 12588899; 14695900; 32123855 3 0 0 -Chpt1 CHPT1 EC 2.7.8.2; Lipid Metabolism - ether lipid; Lipid Metabolism - glycerophospholipid; Membrane protein, integral; Membrane protein, multi-pass; Transferase Q8C025 212862 10|10 C1 mouse K283-ub 12718510 ILAIMIYkKSATNMF protein degradation; enzymatic activity, inhibited 20018880 1 0 0 -SLC6A9 GlyT1 iso3 Membrane protein, integral; Membrane protein, multi-pass; Transporter, SLC family P48067-3 6536 1p34.1 human K633-ub 7761221 VQPLHPDkAQIPIVG receptor internalization, induced; protein degradation endocytosis, induced 19473961 1 5 1 -HOXA10 HOXA10 DNA-binding; Transcription factor P31260 3206 7p15.2 human K338-ac 31094516 LTAKSGRkKRCPYTK Homeodomain protein degradation transcription, inhibited; cell adhesion, inhibited 24037888 1 0 0 -IRF6 IRF6 DNA-binding; Transcription factor O14896 3664 1q32.2 human S424-p 27451041 GSVRLQIsTPDIKDN activity, induced; protein conformation transcription, induced 24872416; 25246526 3 9 0 -PDX1 PDX1 DNA-binding; Transcription factor P52945 3651 13q12.2 human S66-p 458402 QGSPPDIsPYEVPPL transcription, induced 12810726 3 0 0 -ABI3 ABI3 Adaptor/scaffold Q9P2A4 51225 17q21.32 human S216-p 4755287 FSLASAGsAEGVGGA protein stabilization; molecular association, regulation carcinogenesis, induced; cell motility, induced FAT10(INDUCES) 36926204 1 4 0 -PRPF19 PRPF19 EC 6.3.2.-; EC 6.3.2.19; Ligase; RNA splicing; Spliceosome; UBIQUITIN LIGASE; Ubiquitin conjugating system; Ubiquitin ligase Q9UMS4 27339 11q12.2 human S149-p 25247501 VPQAVPSsQPSVVGA DNA repair, induced; apoptosis, inhibited 22529335 1 1 0 cell life span extension -SMN1 SMN RNA processing; RNA-binding Q16637 6606 5q13.2 human Y127-p 1022804 RETCVVVyTGYGNRE SMN molecular association, regulation; intracellular localization coilin(INDUCES) 24602413 1 2 0 -Shtn1 SHOT1 Unknown function A0MZ67 292139 1q55 rat S101-p 4761847 NKTLKRIsMLYMAKL molecular association, regulation; intracellular localization cell motility, induced; cytoskeletal reorganization Cortactin(INDUCES) 23453953; 26261183 4 5 0 SHOT1 phosphorylation increases binding affinity with F-Actin and induces axonal outgrowth; signal?force transduction in axon outgrowth -PFKFB3 PFKFB3 Carbohydrate Metabolism - fructose and mannose; EC 2.7.1.105; EC 3.1.3.46; KINASE; Kinase, other; Motility/polarity/chemotaxis; PHOSPHATASE; Phosphatase (non-protein) Q16875 5209 10p15.1 human S478-p 9318263 TKKPRINsFEEHVAS protein stabilization; ubiquitination; enzymatic activity, induced carcinogenesis, induced; cell motility, induced; cell growth, induced 33931981 2 6 5 promotes glycolysis and Paclitaxel resistance; inhibits ubiquitination -EIF4ENIF1 4E-T Karyopherin; Nuclear import; Translation Q9NRA8 56478 22q12.2 human S693-p 3213600 ASITSMLsPSFTPTS EIF4E-T molecular association, regulation 4E-T(INDUCES) 22966201 1 6 0 required for processing bodies (PBs or P bodies) assembly -PLSCR1 PLSCR1 Calcium-binding; Membrane protein, integral O15162 5359 3q24 human Y69-p 2915403 PVPNQPVyNQPVYNQ molecular association, regulation; intracellular localization carcinogenesis, induced; cell growth, induced; transcription, induced SHC1(INDUCES); STAT3(INDUCES) DNA(INDUCES) 12871937; 32292520 3 0 0 induces binding to STAT1 promoter and STAT1 expression -SPHK2 SPHK2 EC 2.7.1.91; Kinase, lipid; Lipid Metabolism - sphingolipid Q9NRA0 56848 19q13.33 human S421-p 486447 SPLHRSVsDLPLPLP intracellular localization 17635916 1 0 0 regulation of nuclear shuttling -DEPDC5 DEPDC5 Unknown function O75140 9681 22q12.2-q12.3 human S1530-p 3845300 QQRRRRNsTSSTNQN DEPDC5_CTD phosphorylation carcinogenesis, induced; cell growth, induced 31548394 1 8 19 induces phosphorylation of mTORC1 substrates -Pdc phosducin G protein regulator, misc. P20942 25343 13q21 rat S106-p 10431701 QDMHQKLsFGPRYGF Phosducin molecular association, regulation G-gamma 2(DISRUPTS); G-beta 1(DISRUPTS) 11331285 1 0 0 -APP APP iso4 Apoptosis; Cell surface; Membrane protein, integral; Receptor, misc.; Transcription factor P05067-4 351 21q21.3 human Y682-p 448202 SKMQQNGyENPTYKF APP_amyloid molecular association, regulation; intracellular localization signaling pathway regulation Fe65(DISRUPTS); Abl iso4(NOT_REPORTED) 11279131; 24086696 14 20 864 APP both phosphorylated and not phosphorylated at Y682 interacts with Abl; diminished nuclear signaling -Dync1i1 DYNC1I1 Microtubule-binding; Motility/polarity/chemotaxis; Motor Q63100 29564 4q13 rat S100-p 6006907 PTPMSPSsKSVSTPS molecular association, regulation cytoskeletal reorganization dynactin 1(DISRUPTS) 11340075; 19061245 3 1 0 -GAPDH GAPDH Carbohydrate Metabolism - glycolysis and gluconeogenesis; EC 1.2.1.12; Oxidoreductase P04406 2597 12p13.31 human K254-ac 474649 CRLEKPAkYDDIKKV Gp_dh_C enzymatic activity, induced carcinogenesis, induced; cell growth, induced 24362262 2 8 10 -Mfn2 MFN2 Cell cycle regulation; Cytoskeletal; EC 3.6.5.-; Hydrolase; Membrane protein, integral; Membrane protein, multi-pass; Mitochondrial Q8R500 64476 5q36 rat S442-p 4746700 AEEIRRLsVLVDEYQ cell cycle regulation; autophagy, induced; apoptosis, inhibited; cell growth, altered 20303493; 36682578 6 2 0 induces mitophagy -TCF3 E2A Cell development/differentiation; DNA-binding; Oncoprotein; Transcription factor P15923 6929 19p13.3 human S245-p 455906 PMLGGGSsPLPLPPG cell growth, altered 11114297 1 0 0 -ID3 ID3 DNA-binding; Transcription, coactivator/corepressor Q02535 3399 1p36.12 human Y48-p 35524904 LDDMNHCySRLRELV HLH protein stabilization 25090023 1 1 0 regulates vascular EC survival and growth of microvascular lesions -Cryab CRYAB Chaperone; Heat shock protein P23927 12955 9 A5.3|9 27.75 cM mouse S19-p 447728 RPFFPFHsPSRLFDQ Crystallin protein degradation 29088822 26 16 2 -VIPR1 VIPR1 GPCR, family 2; Membrane protein, integral; Membrane protein, multi-pass; Motility/polarity/chemotaxis; Receptor, GPCR P32241 7433 3p22.1 human T429-p 455876 SGGSNGAtCSTQVSM receptor desensitization, altered 16554109 2 0 0 -BCL2L1 Bcl-xL Apoptosis; Autophagy; Membrane protein, integral; Mitochondrial Q07817 598 20q11.21 human T115-p 448162 LTSQLHItPGTAYQS Bcl-2 apoptosis, induced 10617621 2 0 0 -CDKN1B p27Kip1 Cell cycle regulation; Inhibitor; Oncoprotein; Protein kinase, regulatory subunit P46527 1027 12p13.1 human T157-p 448645 GIRKRPAtDDSSTQN protein degradation; molecular association, regulation; intracellular localization; phosphorylation cell cycle regulation; cell motility, induced; apoptosis, inhibited; transcription, induced; cytoskeletal reorganization; cell growth, altered KPNA1(DISRUPTS); 14-3-3 epsilon(INDUCES); CCND1(INDUCES); CDK4(INDUCES); JAK2(INDUCES); 14-3-3 beta(INDUCES); 14-3-3 theta(INDUCES); KPNA5(INDUCES); 14-3-3 gamma(INDUCES) 12244301; 12244302; 12244303; 15057270; 15579463; 15743786; 16790529; 18519679; 18570873; 18593906; 18710949; 19118035; 22139837; 23707388; 25684140; 26684356; 26701207 25 0 1 -CDK5R1 CDK5R1 Protein kinase, regulatory subunit Q15078 8851 17q11.2 human T138-p 471393 PAVTSAGtPKRVIVQ CDK5_activator protein degradation; molecular association, regulation; protein stabilization; protein conformation; activity, inhibited cytoskeletal reorganization; cell growth, altered 17121855; 18326489; 20976519; 26631721 8 1 0 augments its F-actin bundling activity, disrupts microtubule binding; regulates microtubule-polymerizing and binding activities -Syk Syk EC 2.7.10.2; KINASE; Kinase, protein; Protein kinase, TK; Protein kinase, tyrosine (non-receptor) Q64725 25155 17p14 rat Y317-p 447658 STVSFNPyEPTGGAW enzymatic activity, inhibited 10605028; 20828828 21 30 1019 -STK3 MST2 Autophagy; EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, STE; Protein kinase, Ser/Thr (non-receptor) Q13188 6788 8q22.2 human T384-p 3195191 GTMKRNAtSPQVQRP molecular association, regulation; ubiquitination; intracellular localization; enzymatic activity, inhibited; phosphorylation cell cycle regulation; carcinogenesis, induced; apoptosis, altered; signaling pathway regulation MST2(DISRUPTS); RASSF1(DISRUPTS); RAF1(INDUCES) 20086174; 37739411 2 8 36 TRIM69 regulates centrosome dynamics and mitotic progression and centrosome amplification, regulates centrosome clustering, promotes triple-negative breast cancer; TRIM69A regulates MST2 ubiquitination and intracellular localization -Sort1 SORT1 Membrane protein, integral; Receptor, misc. Q6PHU5 20661 3|3 F2.3-F3 mouse K812-ub 34666300 LDSTSHAkSGYHDDS protein degradation 24986865 1 0 0 -Syt12 SYT12 Membrane protein, integral; Vesicle Q920N7 171180 19|19 A mouse S97-p 473040 GPPSRKGsLSIEDTF neural plasticity 23739973 2 2 0 induction of hippocampal mossy-fiber LTP -Lig4 LIG4 EC 6.5.1.1; Ligase Q8BTF7 319583 8|8 A1.1 mouse S650-p 454069 HLKAPNLsNVNKVSN protein stabilization 15194694 1 0 0 -RRAD RRAD G protein; G protein, monomeric; G protein, monomeric, RGK P55042 6236 16q22.1 human S214-p 457394 LVRSREVsVDEGRAC Ras molecular association, regulation Calmodulin(INDUCES) 9677319 1 0 0 -KRT8 K8 Cytoskeletal P05787 3856 12q13.13 human K393-ac 1983600 IEIATYRkLLEGEES Filament cytoskeletal reorganization 18203277 1 5 15 intermediate filament stabilization -TRPV6 TRPV6 Channel, calcium; Membrane protein, integral; Membrane protein, multi-pass Q9H1D0 55503 7q34 human T742-p 11381600 WERLRQGtLRRDLRG activity, induced; molecular association, regulation; activity, inhibited carcinogenesis, induced Calmodulin(INDUCES) 11248124; 32186440 2 0 0 -ORAI1 ORAI1 Channel, calcium; Membrane protein, integral; Membrane protein, multi-pass Q96D31 84876 12q24.31 human S34-p 48990000 SRRSRRRsGDGEPPG activity, inhibited cell growth, inhibited; cell motility, inhibited 31036819; 31652779 3 0 0 -IQGAP1 IQGAP1 GAP; GAP, Ras; Motility/polarity/chemotaxis P46940 8826 15q26.1 human K556-ub 15390899 LDEGDAQkTLQALQI molecular association, regulation CDC42(DISRUPTS); RAC1(DISRUPTS); CDC42(INDUCES); RAC1(INDUCES) 32094223 1 4 6 K556KR compared to WT; 6KR mutant compared to WT -CASP8 CASP8 Apoptosis; EC 3.4.22.61; Protease Q14790 841 2q33.1 human Y380-p 460647 TDSEEQPyLEMDLSS Peptidase_C14 molecular association, regulation; intracellular localization; protein processing; enzymatic activity, inhibited; phosphorylation carcinogenesis, induced; apoptosis, altered; cell motility, induced; apoptosis, induced; transcription, induced; cell growth, induced; apoptosis, inhibited; cell motility, altered; cell adhesion, altered IKKA(INDUCES); IKKB(INDUCES); Src(INDUCES); PIK3R1(NOT_REPORTED); IkB-alpha(INDUCES); NFkB-p65(INDUCES); PIK3R1(INDUCES) 16619028; 18086677; 18089778; 18216014; 18974049; 19851329; 27109099; 34367939; 36460775 10 3 35 induces NFKB phosphorylation; enhances Src phosphorylation; ; phosphorylation of this site in pro-caspase-8 form supresses protein autocleavage and apoptosis; localized to lamella in adherent cells leading to enhanced migration; impeding native CD95 DISC function -HLA-B HLAB Immunoglobulin superfamily; Membrane protein, integral P01889 3106 6p21.33 human K340-ub 2793002 RRKSSGGkGGSYSQA MHC_I_C receptor internalization, induced; protein degradation 18083706 1 3 26 MHC-I down-regulation of HLAB from the cell surface in cancer cells -Ctnnb1 CTNNB1 Actin-binding; Cell adhesion; Motility/polarity/chemotaxis; Nuclear receptor co-regulator; Oncoprotein; Transcription factor Q9WU82 84353 8q32 rat K49-ac 458938 TAPSLSGkGNPEEED protein degradation; activity, inhibited transcription, induced 36470978 17 0 0 Sirt3 mainly mediated ?-catenin K49 deacetylation and induced ubiquitin-dependent degradation, supressing pro?brotic downstream target gene expression -LZTS2 LZTS2 Nuclear export Q9BRK4 84445 10q24.31 human S273-p 25299402 TGPSHSDsGRSSSSK protein degradation; molecular association, regulation; ubiquitination; phosphorylation carcinogenesis, induced; cell motility, induced; cell growth, induced; signaling pathway regulation BTRC(INDUCES) 33420362 1 0 1 induces phosphorylation of downstream targets thus inducing the PI3K/AKT signaling pathway -ANAPC1 APC1 Cell cycle regulation; Ubiquitin conjugating system Q9H1A4 64682 2q13 human S364-p 3212076 ALGVHSFsGVQRFNI activity, induced 27120157 1 5 0 -TAOK1 TAO1 EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, STE; Protein kinase, Ser/Thr (non-receptor) Q7L7X3 57551 17q11.2 human T643-p 3627518 EELNKRQtQKDLEHA activity, induced cell cycle regulation 17396146 1 0 0 -PRPS2 PRPS2 Carbohydrate Metabolism - pentose phosphate pathway; EC 2.7.6.1; Kinase, other; Nucleotide Metabolism - purine P11908 5634 Xp22.2 human S180-p 18014264 GGAKRVTsIADRLNV protein conformation; activity, inhibited cell growth, inhibited 29074724 1 5 0 tumor cell growth inhibited; converts PRPS1/2 hexamers to monomers -NOTCH1 Notch 1 Membrane protein, integral; Motility/polarity/chemotaxis; Oncoprotein; Receptor, misc.; Transcription factor P46531 4851 9q34.3 human S1900-p 20831302 GGLETGNsEEEEDAP Ank_2 molecular association, regulation; activity, inhibited; phosphorylation transcription, induced; transcription, inhibited RBPJ(INDUCES) DNA(DISRUPTS) 21685388; 24220241 2 0 0 -IFNAR1 IFNAR1 Membrane protein, integral; Receptor, cytokine P17181 3454 21q22.11 human S535-p 454418 SSQTSQDsGNYSNED protein degradation; molecular association, regulation; ubiquitination signaling pathway regulation BTRC(NOT_REPORTED) 15337770; 16551269; 21695243; 21865166; 26676772 8 0 0 regulation of PERK1 pathway; attenuation of INF alpha/beta signaling -APEX1 APE1 DNA repair, damage; DNA-binding; Deoxyribonuclease; EC 4.2.99.18; Endoplasmic reticulum; Hydrolase; Lyase; Nuclear receptor co-regulator; Nucleolus; Transcription, coactivator/corepressor P27695 328 14q11.2 human K31-ac 15207804 KKSKTAAkKNDKEAA acetylation; molecular association, regulation; intracellular localization; protein conformation; enzymatic activity, induced DNA repair, induced; cell growth, induced; cell growth, inhibited NPM1(DISRUPTS); XRCC1(INDUCES) RNA(DISRUPTS) 20699270; 22918947; 27994014 4 2 0 -FBXW7 FBXW7 Motility/polarity/chemotaxis; Nucleolus; UBIQUITIN LIGASE; Ubiquitin conjugating system; Ubiquitin ligase Q969H0 55294 4q31.3 human S349-p 25126711 IKPGFIHsPWKSAYI protein degradation cytoskeletal reorganization 22399798 1 1 0 Phosphorylation prevents ubiquitin-dependent degradation of cyclin E and subsequent centriole duplication. -FBXL20 FBXL20 UBIQUITIN LIGASE; Ubiquitin ligase Q96IG2 84961 17q12 human S251-p 1875005604 RGCHKLQsLCASGCS protein degradation; molecular association, regulation carcinogenesis, inhibited; cell growth, inhibited; apoptosis, induced FBXO31(INDUCES) 34587475 1 0 0 -GLI2 GLI2 C2H2-type zinc finger protein; Oncoprotein; Transcription factor P10070 2736 2q14.2 human K757-ac 31077500 TPHTRNTkLPPLPGS protein degradation; ubiquitination; activity, inhibited transcription, inhibited 23762415; 31576013 2 0 0 -POLI POLI DNA repair, damage; EC 2.7.7.7; Transferase Q9UNA4 11201 18q21.2 human K551-ub 50771308 LSGKSREkFQGKGSV protein degradation 26370087 1 1 0 -FBXO5 FBX5 UBIQUITIN LIGASE; Ubiquitin conjugating system; Ubiquitin ligase Q9UKT4 26271 6q25.2 human Y142-p 15339200 ALETSRLyEDSGYSS protein stabilization 20717963 1 0 0 -ARHGEF2 ARHGEF2 GEF; GEF, Rac/Rho; Motility/polarity/chemotaxis Q92974 9181 1q22 human S186-p 1220712 NMRNRTLsVESLIDE molecular association, regulation; intracellular localization cytoskeletal reorganization TUBB2B(DISRUPTS) 21513698 1 1 1 inhibits microtubule binding and stabilization, acetylation, regulates cell polarization -GCK GK Carbohydrate Metabolism - amino sugar and nucleotide sugar; Carbohydrate Metabolism - galactose; Carbohydrate Metabolism - glycolysis and gluconeogenesis; Carbohydrate Metabolism - starch and sucrose; EC 2.7.1.2; Kinase, other; Mitochondrial P35557 2645 7p13 human S411-p 15426313 ITVGVDGsVYKLHPS Hexokinase_2 enzymatic activity, inhibited; protein conformation 21420961 0 1 1 -YWHAH 14-3-3 eta Adaptor/scaffold; Nuclear receptor co-regulator Q04917 7533 22q12.3 human S25-p 14159200 ERYDDMAsAMKAVTE 14-3-3 molecular association, regulation carcinogenesis, induced; cell motility, induced; cytoskeletal reorganization; transcription, inhibited; signaling pathway regulation Snail2(INDUCES) 33116123 1 4 0 after binding Snali2, induces Snail2 binding to CDH1 promoter, thus inducing cancer invasion through the KHK-A-YWHAH-SLUG-CDH1 pathway -XRCC5 Ku80 DNA-binding; EC 3.6.1.-; EC 3.6.4.-; Helicase; Nuclear receptor co-regulator; Nucleolus; RNA-binding P13010 7520 2q35 human K156-ub 15391472 IIIHSLKkCDISLQF Ku_N molecular association, regulation DNA repair, induced DNA(DISRUPTS) 27895153 1 1 11 -TP53 p53 Activator; DNA-binding; Motility/polarity/chemotaxis; Nuclear receptor co-regulator; Transcription factor; Tumor suppressor P04637 7157 17p13.1 human T18-p 447541 EPPLSQEtFSDLWKL P53_TAD protein degradation; protein stabilization; acetylation; molecular association, regulation; protein conformation cell cycle regulation; carcinogenesis, induced; apoptosis, altered; cell growth, induced; transcription, induced; transcription, altered S100B(INDUCES); S100A1(INDUCES); S100A4(INDUCES); CBP(INDUCES); MDM2(DISRUPTS); S100A6(INDUCES); p300(INDUCES); S100A2(INDUCES) DNA(INDUCES) 10734067; 11258706; 11875057; 12860987; 15542844; 18794113; 19819244; 20962272; 22112863; 25584963; 26742101; 33745968; 34168813 35 0 0 -Pebp1 RKIP Lipid-binding; Protein kinase, regulatory subunit P31044 29542 12q16 rat S153-p 448755 RGKFKVEsFRKKYHL PBP molecular association, regulation; enzymatic activity, inhibited; activity, inhibited; enzymatic activity, induced signaling pathway regulation RAF1(DISRUPTS) 12551925; 27568556; 35696587 9 16 1 regulates ?-AR signaling through inhibition of GRK2 activity,; BK-induced functional DOR competence in sensory neurons; RKIP inhibits MAP kinase activation in response to growth factors or PKC activators, and PKC can regulate Raf-1 signaling through phosphorylation of RKIP. Classical and atypical PKCs phosphorylate RKIP on Ser-153, which results in the displacement of RKIP from Raf-1, freeing Raf-1 to activate downstream targets.. ; enhances PKA activity -CD79A Ig-alpha Immunoglobulin superfamily; Membrane protein, integral P11912 973 19q13.2 human K225-ub 12113956 IGDVQLEkP______ intracellular localization 32127472 1 3 3 in cytoplasm -DLGAP5 DLG7 Cell cycle regulation; Microtubule-binding Q15398 9787 14q22.3 human S627-p 456345 VKLFSGLsVSSEGPS molecular association, regulation; intracellular localization KIF5B(INDUCES); KPNB1(INDUCES) 37484914 2 7 0 -UBE2K UBE2K EC 6.3.2.19; Ligase; UBIQUITIN LIGASE; Ubiquitin conjugating system; Ubiquitin ligase P61086 3093 4p14 human K14-sm 12004435 QRIKREFkEVLKSEE UQ_con molecular association, regulation; ubiquitination; protein conformation UBE1(DISRUPTS) 15723079 2 2 0 inhibits ubiquitination -RUNX1 AML1 iso8 DNA-binding; Oncoprotein; Transcription factor Q01196-8 861 21q22.12 human T300-p 454403 SPSVHPAtPISPGRA protein degradation cell differentiation, induced 16046550; 17015473; 22531928 6 1 8 -KAT7 MYST2 ACETYLTRANSFERASE; Acetyltransferase; EC 2.3.1.48; Nuclear receptor co-regulator; Transcription, coactivator/corepressor O95251 11143 17q21.33 human T97-p 3178404 KKYPLRQtRSSGSET protein stabilization; acetylation; ubiquitination cell growth, induced 33014433; 34535630 2 6 0 inhibits ubiquitination mediated degradation; induces H4 acetylation -Pde4b PDE4B EC 3.1.4.53; Nucleotide Metabolism - purine; Phosphodiesterase Q8VBU5 18578 4 C6|4 46.99 cM mouse S118-p 449097 GHSQRREsFLYRSDS enzymatic activity, induced 26192746 4 22 1 -MAPT Tau iso8 ACETYLTRANSFERASE; Acetyltransferase; Cytoskeletal P10636-8 4137 17q21.31 human S396-p 449081 GAEIVYKsPVVSGDT O-GlcNAc glycosylation; molecular association, regulation; protein processing; intracellular localization; protein conformation; phosphorylation cell differentiation, inhibited; apoptosis, induced; cell growth, inhibited; autophagy, inhibited; cytoskeletal reorganization TUBA1A(DISRUPTS); TUBA4A(DISRUPTS); Tau iso8(INDUCES); TUBB(DISRUPTS) 10818091; 11034902; 12414518; 14761950; 15190058; 15542598; 16687396; 18052981; 18725412; 19451179; 24312574; 33710538; 33895139; 33967735; 34220449; 34560101; 8318230 192 49 90 -RAP1GAP2 RAP1GAP2 GAP; GAP, Ras Q684P5 23108 17p13.3 human S7-p 455267 _MFGRKRsVSFGGFG molecular association, regulation cell adhesion, induced 14-3-3 zeta(DISRUPTS); 14-3-3 beta(DISRUPTS) 18039662 3 3 10 -BRD4 BRD4 KINASE; Kinase, protein; Protein kinase, Ser/Thr (non-receptor); Protein kinase, atypical O60885 23476 19p13.12 human S492-p 27806305 SSDSSSDsSSDSDSS molecular association, regulation BID(INDUCES) 23317504 1 0 0 -KCNMB4 KCNMB4 Channel, potassium; Membrane protein, integral; Membrane protein, multi-pass Q86W47 27345 12q15 human S210-p 451270 AMKKRKFs_______ activity, inhibited 11790768 1 0 0 regulates slowpoke K(+) channel kinetics -PIN4 PIN4 EC 5.2.1.8; Isomerase; Mitochondrial; Nucleolus Q9Y237 5303 Xq13.1 human Y122-p 456175 PVKTKFGyHIIMVEG Rotamase_3 cell growth, induced 29323298 1 18 150 mitochondrial respiration and tumour growth, expression of F3?T3 fusion induces peroxisome biogenesis through phosphorylation of PIN4 Y122 -CASP8 CASP8 Apoptosis; EC 3.4.22.61; Protease Q14790 841 2q33.1 human Y448-p 1032277 TILTEVNyEVSNKDD Peptidase_C14 enzymatic activity, inhibited apoptosis, altered 18086677 2 2 0 -PKD2L1 PKD2L1 Channel, cation; Membrane protein, integral; Membrane protein, multi-pass; Motility/polarity/chemotaxis Q9P0L9 9033 10q24.31 human C38-pa 59032203 PHGTLRVcTISSTGP activity, induced 27754867 1 0 0 channel activity regulated independently of phosphorylation -Elk1 ELK1 DNA-binding; Transcription factor A4GTP4 314436 Xq11 rat S159-p 2028400 YMRSGLYsTFTIQSL activity, inhibited transcription, inhibited SRF(DISRUPTS) 18088355 1 0 1 -Pikfyve PIKFYVE Carbohydrate Metabolism - inositol phosphate; EC 2.7.1.150; KINASE; Kinase, lipid; Motility/polarity/chemotaxis; Protein kinase, Ser/Thr (non-receptor) Q9Z1T6 18711 1|1 C2 mouse S307-p 457532 PARNRSAsITNLSLD intracellular localization 23905686 3 55 145 recruitment to vesicles to catalyse PtdIns(3,5)P2 production -Tp53 p53 Activator; DNA-binding; Motility/polarity/chemotaxis; Nuclear receptor co-regulator; Transcription factor; Tumor suppressor P02340 22059 11 B3|11 42.83 cM mouse S389-p 447535 VKKVGPDsD______ activity, induced cell cycle regulation; apoptosis, altered; apoptosis, induced; transcription, induced; transcription, altered; cell growth, altered DNA(INDUCES) 15361844; 15456863; 15867355; 18195040; 18606816; 8910602 118 15 0 induced by cyclin E oveerexpression in high density cells; in response to pX -IRAK1 IRAK1 EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, Ser/Thr (non-receptor); Protein kinase, TKL P51617 3654 Xq28 human T66-p 447722 CERSGQRtASVLWPW Death molecular association, regulation; protein conformation; phosphorylation transcription, altered; signaling pathway regulation TRAF6(DISRUPTS); IRAK1(INDUCES); ACP1(DISRUPTS) 12138165; 18524972 3 0 0 dimerization -Stxbp1 STXBP1 Vesicle O08599 20910 2 B|2 22.09 cM mouse T479-p 25698802 TYQLSRWtPIIKDIM Sec1 molecular association, regulation; protein processing neural plasticity; apoptosis, inhibited APBA1(INDUCES); STX1A(INDUCES) 22765017; 32081899 2 0 0 induced synaptic recovery; regulates APP processing and synaptic vesicle trafficking; cell viability increased -Rara RARA DNA-binding; Nuclear receptor; Oncoprotein; Transcription factor P11416 19401 11 D|11 62.76 cM mouse S77-p 455459 EIVPSPPsPPPLPRI activity, induced transcription, altered 9230306 11 2 0 -PFN1 profilin 1 Actin-binding; Cytoskeletal; Motility/polarity/chemotaxis P07737 5216 17p13.2 human S138-p 2850008 MASHLRRsQY_____ Profilin molecular association, regulation; intracellular localization; activity, inhibited cell cycle regulation; carcinogenesis, induced; cell growth, inhibited; cell motility, induced; cell growth, induced; apoptosis, inhibited ACTA1(DISRUPTS); Huntingtin(DISRUPTS); VASP(DISRUPTS) 18573880; 25084196; 25681442; 30814249 9 0 0 migration and invasion ; inhibits cell migration; inhibits anitumor activity of profilin-1 in the nucleus -NCOA1 SRC-1 ACETYLTRANSFERASE; Acetyltransferase; DNA-binding; EC 2.3.1.48; Nuclear receptor co-regulator; Oncoprotein; Transcription, coactivator/corepressor Q15788 8648 2p23.3 human S1185-p 449064 GTPPASTsPFSQLAA DUF1518 transcription, altered 11073973; 12163482 4 0 0 -Gabra2 GABRA2 Membrane protein, integral; Membrane protein, multi-pass; Transporter; Transporter, ion channel P26048 14395 5 C3.1|5 37.59 cM mouse S359-p 1869636101 DKKKEKGsVMIQNNA molecular association, regulation; intracellular localization neural plasticity ARHGEF9(DISRUPTS); gephyrin(DISRUPTS) 32620552 1 1 0 -ACLY ACLY Carbohydrate Metabolism - citrate (TCA) cycle; EC 2.3.3.8; Lyase; Transferase P53396 47 17q21.2 human K554-ac 4131806 EILIPVFkNMADAMR CoA_binding protein stabilization; molecular association, regulation; ubiquitination carcinogenesis, induced; cell growth, induced UBR4(INDUCES) 23932781; 31197036 2 5 1 inhibits ubiquitination, high glucose decreases interaction -Calm1 Calmodulin Calcium-binding; Protein phosphatase, regulatory subunit P0DP29 24242 6q32 rat Y139-p 448708 DGDGQVNyEEFVQMM EF-hand_7 activity, induced; protein stabilization 25830911 4 5 18 -Fmr1 FMR1 Nucleolus; RNA-binding; Translation Q80WE1 24948 Xq37 rat S478-p 469583 NSEASNAsETESDHR FXMRP1_C_core translation, inhibited 22539853 21 6 0 Phosphorylated FMR1 suppresses translation of Arc; Dephosphorylation by PPP2CA is necessary for mGluR-triggered dendritic Arc expression. -PML PML Nucleolus; Oncoprotein; SUMO LIGASE; SUMO conjugating system; SUMO ligase; Transcription factor; Tumor suppressor; Ubiquitin conjugating system P29590 5371 15q24.1 human S8-p 470923 MEPAPARsPRPQQDP sumoylation apoptosis, altered 19015637 1 32 1 induces sumoylation -ANLN anillin iso2 Actin-binding; Motility/polarity/chemotaxis Q9NQW6-2 54443 7p14.2 human Y634-p 450421 SEDRDLLySIDAYRS intracellular localization cell cycle regulation 28081137 1 7 38 anillin recruitment to the equatorial cortex at anaphase -Xbp1 XBP1 iso2 DNA-binding; Transcription factor O35426-2 22433 mouse K257-ac 1879877100 RFDHVYTkPLVLEIP protein degradation apoptosis, induced 31541078 1 1 0 K257 and 297 mediates hepatic steatosis, apoptosis, and insulin resistance -Ahcyl1 AHCYL1 Amino Acid Metabolism - cysteine and methionine; EC 3.3.1.1; Hydrolase; Other Amino Acids Metabolism - selenoamino acid Q80SW1 229709 3 F2.3|3 46.83 cM mouse T82-p 456617 YSSAASYtDSSDDEV molecular association, regulation PIP5K1A(INDUCES) 26509711 1 3 3 -DYRK2 DYRK2 iso2 EC 2.7.12.1; KINASE; Kinase, protein; Protein kinase, CMGC; Protein kinase, dual-specificity (non-receptor) Q92630-2 8445 12q15 human S483-p 1874397810 SVKRITEsTGAITSI cell cycle regulation; apoptosis, induced 34363019 1 1 0 -HK2 HK2 Carbohydrate Metabolism - amino sugar and nucleotide sugar; Carbohydrate Metabolism - fructose and mannose; Carbohydrate Metabolism - galactose; Carbohydrate Metabolism - glycolysis and gluconeogenesis; Carbohydrate Metabolism - starch and sucrose; EC 2.7.1.1; Kinase, other; Mitochondrial P52789 3099 2p12 human K315-sm 1881215706 LILVKMAkEELLFGG carcinogenesis, inhibited; cell growth, inhibited 33753739 1 0 0 SUMO-defective HK2 contributes to prostate cancer cell proliferation and tumorigenesis -Cd22 CD22 Cell surface; Membrane protein, integral P35329 12483 7 B1|7 19.26 cM mouse Y843-p 456699 PEDESIHySELVQFG molecular association, regulation; activity, inhibited; phosphorylation SHP-1(INDUCES) 11551923; 18024433; 27276708 6 0 5 negatively regulate calcium signal -UBE2I UBC9 EC 6.3.2.-; EC 6.3.2.19; Ligase; Nuclear receptor co-regulator; SUMO LIGASE; SUMO conjugating system; SUMO ligase; UBIQUITIN LIGASE; Ubiquitin conjugating system; Ubiquitin ligase P63279 7329 16p13.3 human K154-sm 60338001 RVRAQAKkFAPS___ signaling pathway regulation 27501389 1 1 0 TTR specifically modulates general protein SUMOylation -KCNC4 Kv3.4 Channel, potassium; Membrane protein, integral; Membrane protein, multi-pass Q03721 3749 1p13.3 human S21-p 451078 KSGNKPPsKTCLKEE Potassium_chann receptor inactivation, altered; protein conformation; activity, inhibited 7993631; 9649584 2 1 0 -BSG BSG iso2 Immunoglobulin superfamily; Membrane protein, integral P35613-2 682 19p13.3 human Y140-p 1868502601 PVTDWAWyKITDSED Ig_3 molecular association, regulation carcinogenesis, induced; cell motility, induced MGAT5(INDUCES) 32291412 1 1 0 induce MMP-9 expression -PIAS4 PIAS4 EC 6.3.2.-; Nuclear receptor co-regulator; SUMO LIGASE; SUMO conjugating system; SUMO ligase; Transcription, coactivator/corepressor Q8N2W9 51588 19p13.3 human S18-p 56589715 MVMSFRVsDLQMLLG protein degradation; molecular association, regulation AREL1 iso2(INDUCES) 27162139 1 0 0 -SOX9 SOX9 DNA-binding; Transcription factor P48436 6662 17q24.3 human T236-p 40722389 GQSQGPPtPPTTPKT protein degradation; molecular association, regulation; ubiquitination apoptosis, induced; transcription, altered FBXW7(INDUCES) 27566146; 27625374 2 3 0 -FUNDC1 FUNDC1 Membrane protein, multi-pass; Mitochondrial Q8IVP5 139341 Xp11.3 human K119-ub 15388938 QIKKRANkAAPEINN FUN14 protein degradation autophagy, inhibited 28104734 1 2 11 -Npy1r NPY1R GPCR, family 1; Membrane protein, integral; Membrane protein, multi-pass; Receptor, GPCR P21555 29358 16p14 rat S362-p 2815303 HTDVSKTsLKQASPV receptor internalization, altered 15576634 1 0 0 may be an artifact of the truncation mutants -RHEB RHEB G protein; G protein, monomeric; G protein, monomeric, Rheb Q15382 6009 7q36.1 human S130-p 18157800 LHMERVIsYEEGKAL Ras activity, inhibited; phosphorylation Other(DISRUPTS) 21336308 1 1 0 reduce mTORC1 activity(S6K1 phosphorylation), disrupted Guanine nucleotide binding activity -EPHB3 EphB3 EC 2.7.10.1; KINASE; Kinase, protein; Membrane protein, integral; Protein kinase, TK; Protein kinase, tyrosine (receptor) P54753 2049 3q27.1 human Y614-p 448275 VYIDPFTyEDPNEAV EphA2_TM molecular association, regulation RASA1(INDUCES); Fyn(INDUCES); CRK(INDUCES) 9674711 1 25 200 -PIN1 PIN1 EC 5.2.1.8; Isomerase; Nuclear receptor co-regulator Q13526 5300 19p13.2 human S138-p 25519816 QKPFEDAsFALRTGE Rotamase intracellular localization cell cycle regulation; transcription, induced 22566623; 34052323 3 2 0 -XPC XPC DNA repair, damage Q01831 7508 3p25.1 human S94-p 3194024 VIKDEALsDGDDLRD ubiquitination DNA repair, induced 29660033 1 45 2 UVB-induced DNA damage repair; recruitment of NER factors to the chromatin post-UVB irradiation -Star STAR Carrier; Lipid-binding; Mitochondrial P51557 20845 8 A2|8 14.17 cM mouse S232-p 2089100 VLHPLAGsPSKTKLT START activity, induced; intracellular localization; enzymatic activity, induced 19007846; 24945345 3 0 0 retention of StAR at OMM, mitochondrial association, regulation of cholesterol transport; promotes progesterone production -Src Src iso1 EC 2.7.10.2; KINASE; Kinase, protein; Oncoprotein; Protein kinase, TK; Protein kinase, tyrosine (non-receptor) P05480-1 20779 2 H1|2 78.35 cM mouse Y527-p 7445100 LQAFLEDyFTSTEPQ enzymatic activity, inhibited 30622194 8 0 0 -Bcar1 P130Cas Adaptor/scaffold; Motility/polarity/chemotaxis Q61140 12927 8|8 E1 mouse Y271-p 451537 NQYGQEVyDTPPMAV carcinogenesis, induced; cell motility, induced 21963850 3 21 285 migration, invasion, metastasis -CDC25B CDC25B iso2 EC 3.1.3.48; Motility/polarity/chemotaxis; Nuclear receptor co-regulator; PHOSPHATASE; Protein phosphatase, dual-specificity P30305-2 994 20p13 human S146-p 465509 PVRLLGHsPVLRNIT M-inducer_phosp intracellular localization cell cycle regulation 12107172 1 8 10 -Nphs1 NPHS1 Cell adhesion; Immunoglobulin superfamily; Membrane protein, integral Q9QZS7 54631 7|7 B1 mouse Y1191-p 2299202 MAFPGHLyDEVERVY molecular association, regulation cytoskeletal reorganization NCK1(INDUCES) 18212058; 34391780 8 0 0 induce podocyte repair -ZC3HC1 NIPA Cell cycle regulation; Ubiquitin conjugating system Q86WB0 51530 7q32.2 human S359-p 483339 TRSWDSSsPVDRPEP molecular association, regulation cell cycle regulation SKP1A(DISRUPTS) 17389604 2 24 11 -RRN3 TIF1A Nucleolus; Transcription initiation complex Q9NYV6 54700 16p13.11 human S649-p 448839 PVLYMQPsPL_____ activity, induced; molecular association, regulation cell cycle regulation; cell growth, induced; transcription, induced POLR2F(INDUCES); POLR1B(INDUCES) 12620228; 15558034; 18498750; 21098478 4 5 1 -DCLRE1C Artemis DNA repair, damage; Deoxyribonuclease; EC 3.1.-.- Q96SD1 64421 10p13 human T656-p 38410200 SDFEVPStPEAELPK molecular association, regulation; intracellular localization DNA repair, induced PAXIP1(INDUCES) 25512557 1 1 0 Artemis prevents end resection and promotes non-homologous end joining -Hsp90aa1 HSP90A Chaperone; Heat shock protein P07901 15519 12 F1|12 60.75 cM mouse K295-ac 486377 QEELNKTkPIWTRNP HSP90 molecular association, regulation; intracellular localization FKBP5(INDUCES); FKBP4(DISRUPTS) 25442004 4 3 0 inhibits GR nuclear translocation -TRPV5 TRPV5 Channel, cation; Membrane protein, integral; Membrane protein, multi-pass; Motility/polarity/chemotaxis Q9NQA5 56302 7q34 human T708-p 4710939 WEILRQNtLGHLNLG activity, induced; molecular association, regulation Calmodulin(DISRUPTS) 21576356; 24828496 3 1 0 channel activation, Ca2+ uptake -STK11 LKB1 Autophagy; EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, CAMK; Protein kinase, Ser/Thr (non-receptor); Tumor suppressor Q15831 6794 19p13.3 human S334-p 448146 DTKDRWRsMTVVPYL carcinogenesis, induced; cell growth, inhibited 34193159 3 0 0 -Vps35 VPS35 Vesicle Q9EQH3 65114 8 C3|8 41.61 cM mouse S7-p 486029 _MPTTQQsPQDEQEK molecular association, regulation signaling pathway regulation Other(DISRUPTS) 24240093 1 18 1 Mutation of S7 to alanine inhibited the insulin-stimulated dissociation of VPS35 from low-density microsomal membranes, and inhibited the insulin-stimulated decrease in GLUT4 expression -ADRB2 ADRB2 GPCR, family 1; Membrane protein, integral; Membrane protein, multi-pass; Receptor, GPCR P07550 154 5q32 human T360-p 5403100 GYSSNGNtGEQSGYH molecular association, regulation; receptor internalization, altered ARRB2(INDUCES) 18801735 3 0 0 PD-N mutant (residues 355-364) failed to recruit ARRB2 to the plasma membrane -NR3C1 GR DNA-binding; Mitochondrial; Nuclear receptor; Transcription factor P04150 2908 5q31.3 human S134-p 3178932 ANLNRSTsVPENPKS GCR molecular association, regulation; intracellular localization transcription, induced; transcription, inhibited; transcription, altered PELP1(INDUCES); 14-3-3 zeta(INDUCES) DNA(DISRUPTS) 21930780; 24291004; 26825173 12 11 6 recruitment of ligand-bound GR to the Brk promoter; inhibits interaction with IGFBP1 promoter; impairs dexamethasone-induced glucocorticoid receptor nuclear translocation -FOXM1 FOXM1 iso2 DNA-binding; Transcription factor Q08050-2 2305 12p13.33 human S724-p 18009877 SKILLDIsFPGLDED sumoylation; intracellular localization cell cycle regulation; transcription, induced 25533473 3 1 0 inhibits FOXM1iso2 sumoylation, induces nuclear localization -Btk Btk EC 2.7.10.2; KINASE; Kinase, protein; Protein kinase, TK; Protein kinase, tyrosine (non-receptor) P35991 12229 X E3|X 56.18 cM mouse Y551-p 447486 RYVLDDEyTSSVGSK PK_Tyr_Ser-Thr enzymatic activity, induced cell growth, altered GTF2I(NOT_REPORTED) 7565679; 9012831; 9391111 34 14 136 PI 3-kinase is required for BTK activation and transformation. -H2BC3 H2B DNA-binding P33778 3018 6p22.2 human S14-p 449904 APAPKKGsKKAITKA Histone intracellular localization cell cycle regulation 28740074 10 1 0 cytokinesis, HIPK2/H2B activities at the midbod -FZR1 FZR1 UBIQUITIN LIGASE; Ubiquitin conjugating system Q9UM11 51343 19p13.3 human S163-p 4661904 KSQKLLRsPRKPTRK protein stabilization; molecular association, regulation; activity, inhibited apoptosis, induced APC1(DISRUPTS); CDC23(DISRUPTS) 18818692; 26083744; 30498084 3 0 0 inhibits cyclin B1 degradation; AURKA stabilization -RGS2 RGS2 GAP; GAP, RGS P41220 5997 1q31.2 human S3-p 1870773103 _____MQsAMFLAVQ protein stabilization; molecular association, regulation FBXO44(DISRUPTS) 33008920 1 0 0 -PRKAA2 AMPKA2 Autophagy; EC 2.7.11.1; EC 2.7.11.27; EC 2.7.11.31; KINASE; Kinase, protein; Protein kinase, CAMK; Protein kinase, Ser/Thr (non-receptor) P54646 5563 1p32.2 human Y179-p 11150878 TSCGSPNyAAPEVIS Pkinase enzymatic activity, inhibited; phosphorylation apoptosis, induced; autophagy, inhibited; signaling pathway regulation 34673141 1 1 2 inhibits phosphorylation at T172, regulates ULK1 signaling -CAMKK1 CAMKK1 EC 2.7.11.17; KINASE; Kinase, protein; Protein kinase, Other; Protein kinase, Ser/Thr (non-receptor) Q8N5S9 84254 17p13.2 human S475-p 486103 RREERSMsAPGNLLV molecular association, regulation; enzymatic activity, inhibited 14-3-3 eta(INDUCES) 18242179 2 14 7 14-3-3 inhibits CAMKK1 activity. -PHLPP1 PHLPP EC 3.1.3.16; PHOSPHATASE; Protein phosphatase, Ser/Thr (non-receptor); Tumor suppressor O60346 23239 18q21.33 human S345-p 1871700801 RAPRPVVsDTESFSL cell cycle regulation 33397691 1 1 0 -MAVS MAVS Adaptor/scaffold; Membrane protein, integral Q7Z434 57506 20p13 human K500-ub 7761223 PRPQADRkFQEREVP protein degradation; molecular association, regulation transcription, inhibited; signaling pathway regulation IKKE(INDUCES) 19380491; 26246171 3 0 0 regulates IFN signaling ; inhibits RLR-mediated antiviral signaling -WBP2 WBP2 Cell development/differentiation; Nuclear receptor co-regulator Q969T9 23558 17q25.1 human Y192-p 20612405 MMDGAMGyVQPPPPP molecular association, regulation; intracellular localization carcinogenesis, induced; cell growth, induced; transcription, induced ER-alpha(INDUCES) 21642474 1 0 1 epithelial-mesenchymal transition induced -FXYD1 PLM Cell surface; Channel, misc.; Membrane protein, integral P56513 476487 dog S83-p 451424 EEGTFRSsIRRLSTR activity, induced 17991751 22 20 60 increases Na(+) affinity of ATP1A1/B1 -SMAD1 SMAD1 DNA-binding; Transcription factor Q15797 4086 4q31.21 human S465-p 448363 HNPISSVs_______ activity, induced; molecular association, regulation; intracellular localization transcription, altered SMAD4(INDUCES) 9136927; 9335504 12 20 59 -NEDD4 NEDD4 iso4 EC 6.3.2.-; EC 6.3.2.19; Ligase; Nuclear receptor co-regulator; UBIQUITIN LIGASE; Ubiquitin conjugating system; Ubiquitin ligase P46934-4 4734 15q21.3 human Y43-p 458526 ILGASDPyVRVTLYD C2 protein conformation; enzymatic activity, induced endocytosis, induced; cell growth, induced; signaling pathway regulation 25292214 1 1 1 -HSPA5 GRP78 Chaperone; Heat shock protein; KINASE P11021 3309 9q33.3 human K152-ac 13362603 ISAMVLTkMKETAEA HSP70 molecular association, regulation; phosphorylation apoptosis, induced; signaling pathway regulation PERK(DISRUPTS) 20371724 1 1 0 induces phosphorylation of elf2a and activation of eIf2a-ATF4-CHOP pathway -Blnk BLNK Adaptor/scaffold Q9QUN3 17060 19 C3|19 34.26 cM mouse T152-p 23303201 AKARLAStLPAPNSL molecular association, regulation; ubiquitination 14-3-3 beta(INDUCES) 22334673 2 0 0 Thr-152 phosphorylation induces BLNK ubiquitination at K37, K38, K42. -NFE2L2 NRF2 DNA-binding; Transcription factor Q16236 4780 2q31.2 human K487-ac 7106323 DFNEMMSkEQFNEAQ bZIP_Maf molecular association, regulation transcription, induced DNA(INDUCES) 19273602 1 1 0 -Sh2b3 LNK Adaptor/scaffold O09039 16923 5 F|5 61.99 cM mouse Y536-p 476934 LRAIDNQyTPLSQLC activity, induced; molecular association, regulation cell motility, altered; cell growth, altered LNK(INDUCES) 18753636 2 4 10 -FOSL2 FRA2 DNA-binding; Transcription factor P15408 2355 2p23.2 human T322-p 14573760 SDSLNSPtLLAL___ methylation cell differentiation, induced; transcription, induced 25547114 2 5 0 -Notch1 Notch 1 Membrane protein, integral; Motility/polarity/chemotaxis; Oncoprotein; Receptor, misc.; Transcription factor Q01705 18128 2 A3|2 18.91 cM mouse K1764-ac 18899501 LWFPEGFkVSEASKK protein stabilization; ubiquitination 21499261 1 1 0 -Drd2 DRD2 GPCR, family 1; Membrane protein, integral; Membrane protein, multi-pass; Receptor, GPCR P61169 24318 8q23 rat K241-ub 4793400 ANLKTPLkGNCTHPE 7tm_1 protein degradation; intracellular localization 18946766 2 0 0 -NUPR1 NUPR1 Apoptosis; Cell cycle regulation; Cell development/differentiation O60356 26471 16p11.2 human K76-ac 465463 KLQNSERkKRGARR_ Phospho_p8 intracellular localization 16294328 1 0 0 regulates nuclear transport -Myocd myocardin Cell development/differentiation; Transcription factor Q8VIM5 214384 11|11 B3 mouse S454-p 3627508 TGFYHFGsTSSSPPI transcription, inhibited 16141410 1 0 0 -Pias1 PIAS1 EC 6.3.2.-; Nuclear receptor co-regulator; SUMO LIGASE; SUMO conjugating system; SUMO ligase; Transcription, coactivator/corepressor A9UK05 300772 8q24 rat S503-p 3177703 LSLPHQAsPVSRTPS enzymatic activity, induced transcription, inhibited 30849179 1 51 11 GADD45A expression -Map3k2 MEKK2 EC 2.7.11.25; KINASE; Kinase, protein; Protein kinase, STE; Protein kinase, Ser/Thr (non-receptor) Q61083 26405 18|18 B1 mouse T283-p 28761201 EYNDGRKtFPRARRT molecular association, regulation; enzymatic activity, inhibited; protein conformation cell growth, induced; transcription, inhibited 14-3-3 epsilon(INDUCES) 23963453 1 2 3 dimerization, transcription of GAL4-c-Jun was increased in T283A mutant -Pkd2 PKD2 Channel, cation; Membrane protein, integral; Membrane protein, multi-pass O35245 18764 5 E5|5 50.68 cM mouse T719-p 25690300 KLKLKRNtVDAISES activity, inhibited 22518003 1 0 0 Negative regulation of flow-induced Ca2+ entry -Cidec CIDEC Apoptosis P56198 14311 6|6 E3 mouse K226-ub 12718507 EEQPAKAkPSSLLPA protein degradation 20089860 1 0 0 -SRSF1 SF2 RNA splicing; RNA-binding; Spliceosome Q07955 6426 17q22 human S207-p 2303910 PSYGRSRsRSRSRSR protein conformation 24449914 2 0 1 RS domain adopts an extended conformation -CALM1 Calmodulin Calcium-binding; Protein phosphatase, regulatory subunit P0DP23 801 14q32.11 human T80-p 448704 MARKMKDtDSEEEIR activity, induced signaling pathway regulation 25108821; 36273583 11 6 0 induces CaV1.2 activity; CaM phosphorylation promotes greater SK channel inhibition through hMR1 mediated PIP2 hydrolysis. -Mitf MITF iso8 DNA-binding; Oncoprotein; Transcription factor Q08874-8 17342 6 D3|6 45.05 cM mouse S307-p 451221 IPSTGLCsPDLVNRI DUF3371 activity, induced; molecular association, regulation transcription, induced SMARCA4(INDUCES); hnRNP P2(INDUCES) 11792706; 24257758 2 22 5 -CRK CRK Adaptor/scaffold; Motility/polarity/chemotaxis; Oncoprotein P46108 1398 17p13.3 human Y239-p 450357 NLQNGPIyARVIQKR SH3_2 molecular association, regulation CSK(INDUCES) 25381819 2 5 268 -Abcc9 ABCC9 Channel, potassium; Membrane protein, integral; Membrane protein, multi-pass; Transporter; Transporter, ABC family Q63563 25560 4q44 rat T632-p 483974 FESCKKHtGVQSKPI activity, induced; protein stabilization; protein conformation 26198630 3 1 0 -GEM GEM G protein; G protein, monomeric; G protein, monomeric, RGK P55040 2669 8q22.1 human S289-p 450648 AFKLKSKsCHDLSVL protein stabilization; molecular association, regulation cytoskeletal reorganization 14-3-3 beta(INDUCES); KPNA5(DISRUPTS) 14701738; 17605761 2 17 0 interaction abolished in triple phosphomimetic mutant S261/287/289D; Cell flattening and neurite extension; Mutation of either S23 or S289 inhibits binding to 14-3-3 -Vav1 VAV1 GEF; GEF, Rac/Rho; Motility/polarity/chemotaxis; Oncoprotein P27870 22324 17 D|17 29.76 cM mouse Y160-p 447865 AEEDEDLyDCVENEE molecular association, regulation; protein conformation; activity, inhibited; phosphorylation cytoskeletal reorganization; transcription, altered; cell growth, altered VAV1(INDUCES) 10669745; 20141838 9 2 0 -Ptk2 FAK iso2 EC 2.7.10.2; KINASE; Kinase, protein; Protein kinase, TK; Protein kinase, tyrosine (non-receptor) P34152-2 14083 15 D3|15 33.94 cM mouse Y428-p 447887 SGDETDDyAEIIDEE activity, induced; molecular association, regulation; enzymatic activity, induced carcinogenesis, induced; cell motility, induced; cell adhesion, induced; signaling pathway regulation; transcription, altered; cell growth, induced; cell motility, altered; cell adhesion, altered; cytoskeletal reorganization PLCG1(INDUCES); Src iso1(INDUCES) 10430888; 15252114; 17438336; 18031698; 19297531; 19553453; 20442405; 20493699; 21900245; 22138575; 22388104; 28759036 371 31 474 -PML PML iso4 Nucleolus; Oncoprotein; SUMO LIGASE; SUMO conjugating system; SUMO ligase; Transcription factor; Tumor suppressor; Ubiquitin conjugating system P29590-4 5371 15q24.1 human S527-p 451472 PHLDGPPsPRSPVIG DUF3583 protein stabilization apoptosis, altered 15093545 2 46 23 Phosphorylation of PML is associated with enhanced sumoylation and apoptosis induced by As2O3. -Grm7 mGluR7 GPCR, family 3; Membrane protein, integral; Membrane protein, multi-pass; Receptor, GPCR Q68ED2 108073 6|6 E3 mouse S862-p 2846504 NVQKRKRsFKAVVTA molecular association, regulation; receptor internalization, altered PICK1(INDUCES); Calmodulin(DISRUPTS) 18549785 4 0 0 -SASH1 SASH1 Tumor suppressor O94885 23328 6q24.3-q25.1 human S90-p 460917 ELRKRRVsQDLEVEK molecular association, regulation 14-3-3 beta(INDUCES) 19648646 1 44 13 yeast 14-3-3 used for binding assay -Casp2 CASP2 Apoptosis; EC 3.4.22.55; Protease P29594 12366 6 B2.1|6 20.54 cM mouse S384-p 1869992407 MRNTKRGsWYIEALT Peptidase_C14 enzymatic activity, inhibited cell cycle regulation; apoptosis, inhibited 32811973 1 1 0 -Nefm NFM Cytoskeletal P08553 18040 14|14 D1 mouse S537-p 448043 EEDEGVKsDQAEEGG cytoskeletal reorganization 19193875 3 6 0 slightly altered axoplasmic organization in 7S/A mice mutant -CLDN16 Claudin-16 Cell adhesion; Membrane protein, integral; Membrane protein, multi-pass Q9Y5I7 10686 3q28 human T233-p 11555106 AKMYAVDtRV_____ molecular association, regulation; intracellular localization ZO1(DISRUPTS); TRPV5(INDUCES) 31488724 2 0 0 Induce Ca2+permeation; increased the Trpv5 channel conductance and cell surface abundance levels -Ahcyl2 AHCYL2 Amino Acid Metabolism - cysteine and methionine; EC 3.3.1.1; Hydrolase; Motility/polarity/chemotaxis; Other Amino Acids Metabolism - selenoamino acid Q68FL4 74340 6|6 A3.3 mouse S157-p 7172002 ISQSSTDsYSSAASY molecular association, regulation SLC4A4(INDUCES) 27382360 2 0 0 S149 and T172 are also involved in activation of SLCA4 -JUNB JunB Motility/polarity/chemotaxis; Oncoprotein; Transcription factor P17275 3726 19p13.13 human Y182-p 41655504 GPEPPPVyTNLSSYS Jun transcription, induced 26217035 1 1 0 p21 promoter activity upon Adriamycin stimulation -Eif4g1 eIF4G RNA-binding; Translation; Translation initiation D3ZU13 287986 11q23 rat S1147-p 449800 VVQRSSLsRERGEKA activity, induced; molecular association, regulation ELF4(INDUCES); EIF4E(INDUCES) 16263769; 35163752 17 33 1 -CDH1 CDH1 Cell adhesion; Membrane protein, integral; Motility/polarity/chemotaxis; UBIQUITIN LIGASE; Ubiquitin ligase P12830 999 16q22.1 human Y797-p 6158370 TLMSVPRyLPRPANP protein degradation; ubiquitination carcinogenesis, induced 31286874 1 4 46 induces EMT phenotype -PXN PXN Adaptor/scaffold; Cell adhesion; Cytoskeletal; Motility/polarity/chemotaxis P49024 395832 chicken T403-p 448766 VVTALDRtWHPEHFF LIM intracellular localization cell adhesion, altered 9658172 1 1 0 -DTD1 DTD1 DNA replication; EC 3.1.-.-; Hydrolase Q8TEA8 92675 20p11.23 human T187-p 36396302 ESSKERNtPRKEDRS molecular association, regulation cell cycle regulation; cell growth, induced MCM7(INDUCES); MCM3(DISRUPTS) 25258324 1 0 8 decreases DTD1 incorporation into HMW, supports DNA replication initiation -Camk2b CAMK2B EC 2.7.11.17; KINASE; Kinase, protein; Protein kinase, CAMK; Protein kinase, Ser/Thr (non-receptor) P08413 24245 14q21 rat T334-p 48915802 STAASGTtMGLVEQA molecular association, regulation 26291163 1 1 0 inhibits interaction with F-actin, regulates synaptic plasticity -Ldha LDH-A Amino Acid Metabolism - cysteine and methionine; Apoptosis; Carbohydrate Metabolism - glycolysis and gluconeogenesis; Carbohydrate Metabolism - propanoate; Carbohydrate Metabolism - pyruvate; EC 1.1.1.27; Oxidoreductase P06151 16828 7 B3|7 30.6 cM mouse S196-p 1881982200 VLGEHGDsSVPVWSG enzymatic activity, induced 37267363 1 1 0 inhibits p62 degradation -SERINC5 SERINC5 Membrane protein, integral; Membrane protein, multi-pass Q86VE9 256987 5q14.1 human S360-p 1874340202 ARCCFCFsPGGEDTE Serinc protein degradation; molecular association, regulation endocytosis, induced 34380030 1 1 0 induces interaction with HIV-1 Nef protein -Srebf1 SREBP-1 iso1 DNA-binding; Membrane protein, integral; Membrane protein, multi-pass; Transcription factor P56720-1 78968 10q22 rat S418-p 1869370300 SLGSRGSsSGGSDSE protein stabilization; molecular association, regulation; intracellular localization transcription, induced SCAP(INDUCES) 31541353 1 0 0 activates genes involved in de novo lipogenesis -HTR1A 5-HT(1A) GPCR, family 1; Membrane protein, integral; Membrane protein, multi-pass; Receptor, GPCR P08908 3350 5q12.3 human T314-p 1867735500 LPSEAGPtPCAPASF 7tm_1 protein degradation; intracellular localization signaling pathway regulation 30712943 1 0 0 5-HT signaling -MAPKAP1 Sin1 Adaptor/scaffold Q9BPZ7 79109 9q33.3 human S260-p 28758701 PIHKFGFsTLALVEK CRIM protein stabilization cell growth, induced 23928304 1 0 0 high abundance of mTORC2 -CDCA2 CDCA2 Q69YH5 157313 8p21.2 human T412-p 3202359 DESLPANtPLRKGGT PP1_bind molecular association, regulation; intracellular localization; phosphorylation cell cycle regulation; chromatin organization, altered PPP1CC(DISRUPTS); NUP153(DISRUPTS); KPNB1(DISRUPTS) 21820363 1 8 0 -Fosb FosB DNA-binding; Transcription factor P13346 14282 7 A3|7 9.56 cM mouse T149-p 35530404 PRRPREEtLTPEEEE transcription, induced 25143625 1 1 0 -SP7 osterix C2H2-type zinc finger protein; DNA-binding; Transcription factor Q8TDD2 121340 12q13.13 human K312-ac 56714901 YGKASHLkAHLRWHT zf-C2H2 protein stabilization; molecular association, regulation cell differentiation, induced; transcription, induced DNA(INDUCES) 27250035 1 0 0 -NFKBIB IkB-beta Inhibitor Q15653 4793 19q13.2 human S313-p 452013 EKSGPCSsSSDSDSG activity, induced; intracellular localization transcription, inhibited; transcription, altered CCDC32(INDUCES) 12732617; 8887627; 9278383 4 0 0 Phosphorylation blocks NF-kB-directed transcription.; and in vivo, NFkB/Rel activation -TP53 p53 Activator; DNA-binding; Motility/polarity/chemotaxis; Nuclear receptor co-regulator; Transcription factor; Tumor suppressor P04637 7157 17p13.1 human K319-ub 11489913 TSSSPQPkKKPLDGE P53_tetramer protein degradation; molecular association, regulation; intracellular localization KPNA4(DISRUPTS) 19927155 2 2 0 -ITGB1BP1 ICAP1 Cell adhesion; Motility/polarity/chemotaxis O14713 9270 2p25.1 human S25-p 14574783 EISTKSKsVDSSLGG ICAP-1_inte_bdg intracellular localization 32005669 1 8 0 regulates localization of itself and of KRIT1 -ETS1 Ets-1 DNA-binding; Motility/polarity/chemotaxis; Oncoprotein; Transcription factor P14921 2113 11q24.3 human S285-p 449318 QRVPSYDsFDSEDYP Ets1_N_flank molecular association, regulation; activity, inhibited transcription, inhibited DNA(DISRUPTS) 12475968; 25024220 6 10 56 induces autoinhibition -NACA NACA iso1 Motility/polarity/chemotaxis; Transcription, coactivator/corepressor Q13765 4666 12q13.3 human T89-p 18012689 KLGLRQVtGVTRVTI NAC intracellular localization; activity, inhibited cell differentiation, inhibited; transcription, inhibited 30948508 1 2 1 -F2R PAR1 Cell development/differentiation; GPCR, family 1; Membrane protein, integral; Membrane protein, multi-pass; Receptor, GPCR P25116 2149 5q13.3 human S400-p 3627504 DPSSYNSsGQLMASK receptor desensitization, altered 10413505 1 1 0 receptor shutoff (not internalization) -CAMKK1 CAMKK1 EC 2.7.11.17; KINASE; Kinase, protein; Protein kinase, Other; Protein kinase, Ser/Thr (non-receptor) Q8N5S9 84254 17p13.2 human S458-p 486077 KSMLRKRsFGNPFEP enzymatic activity, inhibited 11574071 5 25 21 activity toward PKIV peptide -Gch1 GCH1 Cofactor and Vitamin Metabolism - folate biosynthesis; EC 3.5.4.16; Hydrolase P22288 29244 15p14 rat S51-p 469750 WKAGRPRsEEDNELN enzymatic activity, induced 21163945 3 15 1 possibly in vivo as in vitro closely resembled wild-type -STK4 MST1 Autophagy; EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, STE; Protein kinase, Ser/Thr (non-receptor) Q13043 6789 20q13.12 human T353-p 64227000 TMTDGANtMIEHDDT molecular association, regulation MOB1A(INDUCES); MST1(DISRUPTS) 28373297; 28373298 2 2 0 fluorescence polarization -Dusp8 DUSP8 EC 3.1.3.16; EC 3.1.3.48; Motility/polarity/chemotaxis; PHOSPHATASE; Protein phosphatase, dual-specificity O09112 18218 7 F5|7 87.59 cM mouse T518-p 22598802 PPLDSPGtPSPDGPW enzymatic activity, inhibited signaling pathway regulation 22100391 1 1 0 activates JNK pathway -RANBP1 RANBP1 Cell cycle regulation; G protein regulator, misc.; Microtubule-binding P43487 5902 22q11.21 human S60-p 456058 AKLFRFAsENDLPEW Ran_BP1 intracellular localization carcinogenesis, induced; cell growth, induced; apoptosis, inhibited 30747223 1 56 172 -PYGL PYGL Carbohydrate Metabolism - starch and sucrose; EC 2.4.1.1; Transferase P06737 5836 14q22.1 human S430-gl 1876695600 VDRLRRMsLIEEEGS Phosphorylase phosphorylation; enzymatic activity, induced 34939084 1 1 0 Ser-430 O-GlcNAcylation promotes S15 phosphorylation -Lcp2 SLP76 Adaptor/scaffold Q60787 16822 11|11 A4 mouse Y145-p 448220 LVDDAADyEPPPSNN molecular association, regulation; phosphorylation cell differentiation, altered; apoptosis, altered; cytoskeletal reorganization; cell adhesion, altered; transcription, induced; transcription, altered Btk(INDUCES) 11313406; 12640123; 16456002; 18342008; 18663126 21 1 0 mutation of this site impairs thrombus formation -PXN PXN Adaptor/scaffold; Cell adhesion; Cytoskeletal; Motility/polarity/chemotaxis P49023 5829 12q24.23 human Y31-p 448785 FLSEETPySYPTGNH molecular association, regulation; intracellular localization; phosphorylation carcinogenesis, induced; cell motility, induced; cell growth, induced; cytoskeletal reorganization ERK2(INDUCES); ERK1(INDUCES); DRP1(INDUCES) 26697169; 34475475; 35297710 49 8 64 -H3-3A H3F3A DNA-binding P84243 3020 1q42.12 human S10-p 18545301 TKQTARKsTGGKAPR Histone phosphorylation cell cycle regulation 14583461; 16185088 12 4 0 -Mapk14 P38A EC 2.7.11.24; KINASE; Kinase, protein; Protein kinase, CMGC; Protein kinase, Ser/Thr (non-receptor) P70618 81649 20p12 rat T180-p 447970 RHTDDEMtGYVATRW Pkinase activity, induced; enzymatic activity, induced apoptosis, induced; cell growth, altered 10473611; 25371038; 28039298 401 73 1542 -MVB12B FAM125B Vesicle Q9H7P6 89853 9q33.3 human K290-ub 15167003 KSLAEIEkEYEYSFR DUF2464 intracellular localization 20654576 1 4 0 -CXCR4 CXCR4 GPCR, family 1; Membrane protein, integral; Membrane protein, multi-pass; Receptor, GPCR P61073 7852 2q22.1 human K327-ub 6198957 VSRGSSLkILSKGKR protein degradation 24489825 1 5 1 -MARS1 MARS Aminoacyl-tRNA synthetase; EC 6.1.1.10; Ligase; Other Amino Acids Metabolism - selenoamino acid; Translation; Translation regulation P56192 4141 12q13.3 human S209-p 27452641 LQKQPQPsPAEGRAV methylation; enzymatic activity, induced cell growth, induced; transcription, induced; translation, induced 25097229 1 4 0 induces Met-misacylation; reduce intracellular ROS level -CHRM2 mAChR M2 GPCR, family 1; Membrane protein, integral; Membrane protein, multi-pass; Receptor, GPCR P08172 1129 7q33 human S290-p 459105 SNDSTSVsAVASNMR 7tm_1 receptor internalization, altered 9162044 3 0 0 Mutation of S286 T287 S288 S290 to A caused a faster rate and a greater extent of receptor internalization after agonist stimulation (transients only, not observed in stables). Mutation of all 8 sites prevented internalization (in both transients and stables). -APP APP Apoptosis; Cell surface; Membrane protein, integral; Receptor, misc.; Transcription factor P05067 351 21q21.3 human S679-me 1881129801 DAEFRHDsGYEVHHQ molecular association, regulation APP(NOT_REPORTED) 33328587 1 1 0 formaldehyde (FA) cross-linked with K699 residue in the ?-turn of A? monomer to form A? dimers, and then accelerated A? oligomerization -Fbxl21 FBXL21 UBIQUITIN LIGASE; Ubiquitin ligase Q8BFZ4 213311 13|13 B1 mouse T33-p 1870414702 LCSSLRQtHALSVLL enzymatic activity, induced cell differentiation, induced 36574402 2 0 0 induces MYOZ1 degradation -Syngap1 SynGAP GAP; GAP, Ras F6SEU4 240057 17|17 A3.3 mouse S743-p 27720871 RQSERTRsQPMVLRG DUF3498 activity, induced 25533468 1 2 0 phosphorylation of this site increases HRas GAP activity of S88A/T790A/S817A SunGAP mutant -HDAC3 HDAC3 Apoptosis; Cell cycle regulation; DEACETYLASE; Deacetylase; EC 3.5.1.98; Nuclear receptor co-regulator; Transcription, coactivator/corepressor O15379 8841 5q31.3 human S424-p 455624 DHDNDKEsDVEI___ molecular association, regulation; acetylation; enzymatic activity, induced cell cycle regulation KPNA2(INDUCES); PKG1(INDUCES) 15805470; 26356530; 26663086; 27798112; 32772249 6 21 15 -Nfe2l2 NRF2 DNA-binding; Transcription factor Q60795 18024 2 C3|2 44.75 cM mouse S40-p 450082 SREVFDFsQRQKDYE activity, induced; protein stabilization; molecular association, regulation; ubiquitination; intracellular localization carcinogenesis, induced; transcription, induced KEAP1(DISRUPTS) 12947090; 19920073; 33532181; 35165418 33 0 0 -Nphs1 NPHS1 Cell adhesion; Immunoglobulin superfamily; Membrane protein, integral Q9R044 64563 1q21 rat Y1228-p 469566 CEDPRGIyDQVAADM molecular association, regulation cytoskeletal reorganization NCK1(NOT_REPORTED) 16934223; 18256598; 22013520 10 0 0 -ATP7A ATP7A Apoptosis; Cell development/differentiation; Chaperone; EC 3.6.3.54; Hydrolase; Membrane protein, integral; Membrane protein, multi-pass; Transporter; Transporter, ion channel; Vesicle Q04656 538 Xq21.1 human S1466-p 4733428 YSRASINsLLSDKRS protein stabilization; intracellular localization 29301787 2 17 2 translocation to membrane -HIVEP3 HIVEP3 C2H2-type zinc finger protein; Transcription, coactivator/corepressor Q5T1R4 59269 1p34.2 human S542-p 41452307 VPLLRSHsMPSAACT molecular association, regulation 14-3-3 beta(INDUCES); 14-3-3 sigma(INDUCES); 14-3-3 theta(INDUCES); 14-3-3 zeta(INDUCES); 14-3-3 epsilon(INDUCES); 14-3-3 gamma(INDUCES); 14-3-3 eta(INDUCES) 34341191 1 1 0 -MARK2 MARK2 EC 2.7.11.1; EC 2.7.11.26; KINASE; Kinase, protein; Protein kinase, CAMK; Protein kinase, Ser/Thr (non-receptor) Q7KZI7 2011 11q13.1 human S456-p 453135 STAKVPAsPLPGLER cell cycle regulation; carcinogenesis, induced; apoptosis, inhibited 35780183 1 70 15 -FANCA FANCA DNA repair, damage O15360 2175 16q24.3 human S1149-p 9802800 CLRSRDPsLMVDFIL molecular association, regulation 11855836 1 0 0 Complementation assays showed similar results for WT-FANCA and S1149A mutant. -SNAP23 SNAP23 Vesicle O00161 8773 15q15.1-q15.2 human T24-p 11486600 TDESLEStRRILGLA molecular association, regulation STX4(INDUCES) 12930825 1 2 1 -Th TH Amino Acid Metabolism - tyrosine; EC 1.14.16.2; Endoplasmic reticulum; Mitochondrial; Oxidoreductase; Vesicle P24529 21823 7 F5|7 88.06 cM mouse S40-p 448545 RFIGRRQsLIEDARK TOH_N enzymatic activity, induced neural plasticity 17507557; 18674600; 32358047; 33769619 62 11 11 IRL790-induced neurotransmission -Nr3c1 GR DNA-binding; Mitochondrial; Nuclear receptor; Transcription factor P06536 24413 18p11 rat K297-sm 2532301 SVALPQVkTEKDDFI GCR transcription, inhibited 14663148 5 3 0 -Sox4 SOX4 DNA-binding; Transcription factor Q06831 20677 13 A3.1|13 12.87 cM mouse S315-p 50800249 SGRSSAAsSPAASRS protein degradation cell differentiation, induced 34431536 1 1 0 -PREX1 PREX1 GEF; GEF, Rac/Rho Q8TCU6 57580 20q13.13 human S319-p 4735252 KSTKRTKsINGSLYI activity, induced; activity, inhibited 21042280; 27788493 2 8 0 dephosphorylation of serines 313 and 319 negatively regulate GEF activity -Cav1 caveolin-1 Adaptor/scaffold; Motility/polarity/chemotaxis; Nuclear receptor co-regulator P49817 12389 6|6 A2 mouse K176-ub 15489877 NIRISTQkEI_____ molecular association, regulation carcinogenesis, inhibited ABCB1B(INDUCES); caveolin-1(INDUCES) 26843476 1 1 1 Caveolin1 oligomerization induced -Ksr1 KSR KINASE; Kinase, protein; Protein kinase, Ser/Thr (non-receptor); Protein kinase, TKL Q61097 16706 11 B5|11 46.74 cM mouse S297-p 449296 PTLTRSKsHESQLGN molecular association, regulation 14-3-3 beta(INDUCES); 14-3-3 gamma(INDUCES) 28003362; 9858547 3 25 4 -MCC MCC Cell cycle regulation; Tumor suppressor P23508 4163 5q22.2 human S828-p 25126713 RPHTNETsL______ molecular association, regulation; intracellular localization cytoskeletal reorganization Scribble(INDUCES) 22480440 1 4 0 reduced lamellipodia formation, modified MyosinII-B localization -Ccnd2 CCND2 Cell cycle regulation; Motility/polarity/chemotaxis P30280 12444 6 F3|6 61.92 cM mouse T280-p 469202 EDPDQATtPTDVRDV Cyclin_C protein degradation; intracellular localization 17452458 4 3 11 degradation of itself and p27Kip1 -Scn10a SCN10A Channel, sodium; Membrane protein, integral; Membrane protein, multi-pass Q62968 rat S556-p 2482301 PRSPLPQsPNPGRRH activity, induced 18354022 1 0 0 increases SCN10A sodium channel current density -PML PML Nucleolus; Oncoprotein; SUMO LIGASE; SUMO conjugating system; SUMO ligase; Transcription factor; Tumor suppressor; Ubiquitin conjugating system P29590 5371 15q24.1 human S505-p 468479 EARLARSsPEQPRPS DUF3583 molecular association, regulation C/EBP-epsilon(INDUCES) 17989716 1 41 20 -PAK6 PAK6 EC 2.7.11.1; KINASE; Kinase, protein; Nuclear receptor co-regulator; Protein kinase, STE; Protein kinase, Ser/Thr (non-receptor) Q9NQU5 56924 15q15.1 human S308-p 29666302 SLVAKAQsLPSDQPV molecular association, regulation; enzymatic activity, induced carcinogenesis, induced; cell motility, induced AR(INDUCES) 24130878 1 1 0 promotion of cell motility and invasion -HDAC5 HDAC5 DEACETYLASE; Deacetylase; EC 3.5.1.98; Hydrolase Q9UQL6 10014 17q21.31 human S661-p 7237900 QALGRTQsSPAAPGG intracellular localization 14-3-3 beta(INDUCES) 18951085 2 16 24 14-3-3-dependent nuclear export -FOXO3 FOXO3A Autophagy; DNA-binding; Oncoprotein; Transcription factor O43524 2309 6q21 human S209-p 464289 SSAGWKNsIRHNLSL Forkhead molecular association, regulation; intracellular localization 14-3-3 beta(DISRUPTS) 16751106 4 0 0 -BRAF BRAF EC 2.7.11.1; KINASE; Kinase, protein; Oncoprotein; Protein kinase, Ser/Thr (non-receptor); Protein kinase, TKL P15056 673 7q34 human T440-p 447806 EDRNRMKtLGRRDSS enzymatic activity, inhibited 10869359; 11293329 2 2 5 -ATP7B ATP7B EC 3.6.3.54; Hydrolase; Membrane protein, integral; Membrane protein, multi-pass; Transporter; Transporter, ion channel; Vesicle P35670 540 13q14.3 human S481-p 11267006 ILAKSPQsTRAVAPQ protein stabilization; intracellular localization 21189263 1 4 0 protein trafficking -SAV1 SAV1 Adaptor/scaffold Q9H4B6 60485 14q22.1 human T26-p 4270990 GKYVKKEtSPLLRNL protein conformation apoptosis, induced 21944251 1 3 0 self-dimerization; increase in protein level -MAP2K1 MEK1 EC 2.7.12.2; KINASE; Kinase, protein; Protein kinase, STE; Protein kinase, dual-specificity (non-receptor) Q02750 5604 15q22.31 human S218-p 448514 VSGQLIDsMANSFVG Pkinase intracellular localization; protein conformation; phosphorylation; enzymatic activity, induced cell cycle regulation; carcinogenesis, induced; cell growth, induced; transcription, induced; signaling pathway regulation; cell growth, altered 12466969; 12506122; 12609989; 16585161; 17667937; 19106095; 21893193; 24681949; 27323830; 32076487; 33789117; 33808483; 34262144; 34470822; 35173310; 7731726; 8621729 124 13 83 -Stx1b STX1B Membrane protein, integral; Vesicle P61265 24923 1q37 rat S14-p 450122 ELRSAKDsDDEEEVV molecular association, regulation SNAP-25(INDUCES) 10844023 2 19 5 -Cebpb C/EBP-beta DNA-binding; Motility/polarity/chemotaxis; Transcription factor P28033 12608 2 H3|2 87.58 cM mouse S222-p 408589401 KKTVDKLsDEYKMRR bZIP_2 transcription, induced DNA(INDUCES) 29259016 1 1 0 L-6, IL-1a, Cxcl1, Cxcl2, and Ccr1 -NOX5 NOX5 iso4 EC 1.6.3.-; Membrane protein, integral; Membrane protein, multi-pass; Oxidoreductase Q96PH1-4 79400 15q23 human S475-p 20612400 WTNRLYEsFKASDPL FAD_binding_8 enzymatic activity, induced 21642394 1 1 0 ROS production -PTPN1 PTP1B EC 3.1.3.48; Motility/polarity/chemotaxis; PHOSPHATASE; Phosphatase; Protein phosphatase, tyrosine (non-receptor) O13016 395688 chicken Y152-p 449312 ISEDIKSyYTVRQLE Y_phosphatase molecular association, regulation CDH2(INDUCES) 11106648 5 0 1 -CEBPE C/EBP-epsilon DNA-binding; Motility/polarity/chemotaxis; Transcription factor Q15744 1053 14q11.2 human K121-ac 38557701 DPRAVAVkEEPRGPE molecular association, regulation cell differentiation, induced; transcription, induced DNA(INDUCES) 25568349; 31256937 2 1 0 deletion of R247 or S248 was sufficient for the loss of C/EBPe transcriptional activity, TSA treatment may be able restore the transcriptional activity -FUS hnRNP P2 DNA-binding; Nuclear receptor co-regulator; Oncoprotein; RNA splicing; RNA-binding; SUMO LIGASE P35637 2521 16p11.2 human S182-p 1878186704 GNYGQDQsSMSSGGG molecular association, regulation hnRNP P2(DISRUPTS) 35753345 1 1 0 -Ppargc1b PGC-1 beta Nuclear receptor co-regulator; Transcription, coactivator/corepressor Q8VHJ7 170826 18|18 E1 mouse K994-ac 7761207 ESLPSSGkSKYEAMD intracellular localization transcription, inhibited 19491097 1 1 0 -NOXA1 NOXA1 Activator Q86UR1 10811 9q34.3 human Y110-p 17303900 RGHAAIDyTQLGLRF activity, induced; molecular association, regulation carcinogenesis, altered; cytoskeletal reorganization SH3PXD2B(INDUCES) 20943948 1 0 0 -KDM4C JMJD2C DEMETHYLASE; Demethylase; EC 1.14.11.-; Oxidoreductase Q9H3R0 23081 9p24.1 human S918-p 1869778705 MFDDGSFsRDTFPED protein degradation; molecular association, regulation; ubiquitination signaling pathway regulation BTRC(INDUCES) 31888886 1 0 0 -BCL10 Bcl-10 Apoptosis; Transcription, coactivator/corepressor; Tumor suppressor O95999 8915 1p22.3 human S231-p 469573 PLRSRTVsRQ_____ molecular association, regulation; intracellular localization Bcl-3(INDUCES) 16280327 1 0 1 -UHRF1 UHRF1 DNA-binding; EC 6.3.2.-; EC 6.3.2.19; Ligase; Transcription factor; UBIQUITIN LIGASE; Ubiquitin conjugating system; Ubiquitin ligase Q96T88 29128 19p13.3 human S95-p 3210060 SELSDTDsGCCLGQS protein degradation; molecular association, regulation BTRC(INDUCES) 23297342 1 10 5 -MAP3K2 MEKK2 EC 2.7.11.25; KINASE; Kinase, protein; Protein kinase, STE; Protein kinase, Ser/Thr (non-receptor) Q9Y2U5 10746 2q14.3 human S520-p 1869000 LSGTGMKsVTGTPYW Pkinase phosphorylation; enzymatic activity, induced transcription, altered 16362041 2 3 0 Mutation of S520A inhibits activation and is the key residue. Double mutation of T522A,T524A reduces activation effect. T522A seems to have the least effect of the three single mutations. The triple STT to AAA mutation is akin to kinase dead. Activation leads to Erk5 and JNKK2 phosphorylation/activation. -TRIM28 TIF1B EC 6.3.2.-; KINASE; Kinase, protein; Ligase; Nuclear receptor co-regulator; Protein kinase, atypical; SUMO LIGASE; SUMO ligase; Transcription, coactivator/corepressor; UBIQUITIN LIGASE; Ubiquitin conjugating system; Ubiquitin ligase Q13263 10155 19q13.43 human Y449-p 3576406 PMEVQEGyGFGSGDD molecular association, regulation; phosphorylation DNA repair, induced HP1 alpha(INDUCES) DNA(NOT_REPORTED) 23645696 1 2 2 stimulates phosphorylation of TIF1B S473 and TIF1B S824 in DNA damage response; involved in DNA damage response; inhibits association of HP1alpha with chromatin -Dok1 DOK1 Adaptor/scaffold; Motility/polarity/chemotaxis P97465 13448 6 C3|6 35.94 cM mouse Y146-p 455786 EMLENSLySPTWEGS molecular association, regulation cell cycle regulation; cell motility, altered; cell growth, altered DOK1(INDUCES) 11042170; 18515860 2 1 2 -ERBB3 HER3 EC 2.7.10.1; KINASE; Kinase, protein; Membrane protein, integral; Oncoprotein; Protein kinase, TK; Protein kinase, tyrosine (receptor) P21860 2065 12q13.2 human Y1222-p 448639 SSLEELGyEYMDVGS molecular association, regulation; enzymatic activity, induced carcinogenesis, induced; cell growth, induced; cell motility, induced; apoptosis, inhibited; signaling pathway regulation PIK3R2(INDUCES); PIK3R1(INDUCES) 16729043; 21725367; 34320350 5 0 1 induces ERBB3/PI3K/mTOR pathway; chemotaxis and invasion -Jund JunD Motility/polarity/chemotaxis; Transcription factor P15066 16478 8 B3.3|8 34.15 cM mouse T117-p 473545 SNGLVTTtPTSTQFL Jun transcription, altered 14676207 1 2 4 -CEP192 CEP192 Cell cycle regulation; Microtubule-binding Q8TEP8 55125 18p11.21 human S995-p 41159606 TSPLSHSsPSEISGT molecular association, regulation cell cycle regulation; cytoskeletal reorganization PLK1(INDUCES) 26012549 1 0 0 required for proper spindle formation and mitotic progression -Ppp1r1b DARPP-32 Motility/polarity/chemotaxis; Protein phosphatase, regulatory subunit Q60829 19049 11|11 D mouse S130-p 448046 EEDEEEDsQAEVLKG DARPP-32 activity, induced 11572969 13 4 15 -Nlgn2 NLGN2 Membrane protein, integral Q62888 117096 10q24 rat Y770-p 7294539 RPACPPDyTLALRRA activity, inhibited 27805570 1 0 2 enhancement of inhibitory currents -Ipo13 IPO13 Karyopherin; Nuclear export; Nuclear import Q9JM04 116458 5q36 rat S193-p 15420334 RKGLVRAsLAVECGA Xpo1 molecular association, regulation; intracellular localization; protein conformation ARX(INDUCES); PAX6(INDUCES) 30045875 1 0 1 increases cytoplasmic localization of IPO13 and inhibits its nuclear import -NOXO1 NOXO1 iso3 Adaptor/scaffold Q8NFA2-3 124056 16p13.3 human T341-p 28758706 AIQSRCCtVTRRALE molecular association, regulation NOXA1(INDUCES) 23957209 1 1 0 -JUNB JunB Motility/polarity/chemotaxis; Oncoprotein; Transcription factor P17275 3726 19p13.13 human Y173-p 41655503 PAGPGGVyAGPEPPP Jun transcription, induced 26217035 1 1 0 p21 promoter activity upon Adriamycin stimulation -Itga4 ITGA4 Cell adhesion; Membrane protein, integral; Motility/polarity/chemotaxis; Receptor, misc. Q00651 16401 2 C3|2 47.38 cM mouse R471-me 1883354000 SAVLLRTrPVVIVEA transcription, inhibited 36191854 1 1 0 R471 methylation suppresses pro?brotic gene expression -WEE1 Wee1 EC 2.7.10.2; KINASE; Kinase, protein; Protein kinase, Other; Protein kinase, Ser/Thr (non-receptor); Protein kinase, tyrosine (non-receptor) P30291 7465 11p15.4 human S53-p 451131 GHSTGEDsAFQEPDS protein degradation; molecular association, regulation cell cycle regulation BTRC(INDUCES); FBW1B(INDUCES) 15070733; 15350223; 16085715 4 0 1 -GRK2 GRK2 EC 2.7.11.15; KINASE; Kinase, protein; Protein kinase, AGC; Protein kinase, Ser/Thr (non-receptor) P25098 156 11q13.2 human K21-ub 1872283502 LMAMEKSkATPAARA protein degradation 17006543 1 0 0 -Map3k4 MEKK4 EC 2.7.11.25; KINASE; Kinase, protein; Protein kinase, STE; Protein kinase, Ser/Thr (non-receptor) O08648 26407 17 8.42 cM|17 A1 mouse T1483-p 479428 KLKNNAQtMPGEVNS Pkinase molecular association, regulation; enzymatic activity, induced GADD45A(INDUCES) 27358404 2 2 1 -TP53 p53 Activator; DNA-binding; Motility/polarity/chemotaxis; Nuclear receptor co-regulator; Transcription factor; Tumor suppressor P04637 7157 17p13.1 human S183-p 18675301 CPHHERCsDSDGLAP P53 protein degradation; molecular association, regulation; ubiquitination cell cycle regulation; carcinogenesis, induced; apoptosis, inhibited; transcription, inhibited DNA(DISRUPTS) 22611192; 32873634 3 1 0 -Rb1 Rb Nuclear receptor co-regulator; Oncoprotein; Transcription, coactivator/corepressor; Tumor suppressor P13405 19645 14 38.73 cM|14 D3 mouse S788-p 447979 SPYKFSSsPLRIPGG Rb_C molecular association, regulation E2F1(DISRUPTS) 10207050 52 17 94 -AURKAIP1 AKIP Cell cycle regulation Q9NWT8 54998 1p36.33 human S70-p 999611 MLVPRKMsVSPLESW protein stabilization 17957726 1 1 0 -VAV1 VAV1 GEF; GEF, Rac/Rho; Motility/polarity/chemotaxis; Oncoprotein P15498 7409 19p13.3 human Y745-p 13209302 LTELVEFyQQNSLKD SH2 cell differentiation, altered; cell motility, altered 20028078 2 1 0 -UTRN utrophin Dystrophin complex; Motility/polarity/chemotaxis P46939 7402 6q24.2 human S1258-p 2525745 TLEERMKsTEVLPEK molecular association, regulation DAG1(INDUCES) 19945424 1 3 0 -FHL1 FHL1 iso1 Cell development/differentiation Q13642-1 2273 Xq26.3 human Y149-p 15410160 FPKGEDFyCVTCHET LIM intracellular localization cell growth, induced BCLAF1(INDUCES) 29434030 1 0 2 translocate to the nucleus -EPHB1 EphB1 EC 2.7.10.1; KINASE; Kinase, protein; Membrane protein, integral; Protein kinase, TK; Protein kinase, tyrosine (receptor) P54762 2047 3q22.2 human Y600-p 450470 IYIDPFTyEDPNEAV EphA2_TM molecular association, regulation SHC1(NOT_REPORTED); Src(NOT_REPORTED) 12925710 1 17 120 -NCAPG NCAPG Cell cycle regulation Q9BPX3 64151 4p15.31 human T308-p 5014903 LNALFSItPLSELVG molecular association, regulation; intracellular localization DNA(INDUCES) 18977199 1 0 0 regulates NCAPG localization with chromosomal DNA in mitotic cells -SLC9A5 NHE5 Membrane protein, integral; Membrane protein, multi-pass; Transporter; Transporter, SLC family Q14940 6553 16q22.1 human S577-p 34424902 NLLRESGsGACLDLQ activity, induced 24936055 1 0 0 metabolic stress-induced activation -AURKC AurC EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, Other; Protein kinase, Ser/Thr (non-receptor) Q9UQB9 6795 19q13.43 human T202-p 469107 RRKTMCGtLDYLPPE Pkinase enzymatic activity, induced 27332895 3 6 15 -Hist1h2ail1 H3 DNA-binding Q6LED0 291159 17p11 rat K27-ac 465521 LATKAARkSAPATGG Histone molecular association, regulation DNA(INDUCES) 23382250 74 18 13 -Notch1 Notch 1 Membrane protein, integral; Motility/polarity/chemotaxis; Oncoprotein; Receptor, misc.; Transcription factor Q01705 18128 2 A3|2 18.91 cM mouse K2146-ac 18899508 LKSATQGkKARKPST protein stabilization; ubiquitination 21499261 1 1 0 -SNIP1 SNIP1 Inhibitor Q8TAD8 79753 1p34.3 human K30-sm 15513209 LPAGVVVkQERLSPE molecular association, regulation cell motility, induced; transcription, induced 27703003 1 4 0 SUMOylation decreases the inhibitory effect of SNIP1 on TGF-beta-induced formation of the Smad2/4 and Smad3/4 complexes -MSH3 MSH3 DNA repair, damage P20585 4437 5q14.1 human K123-ac 9930501 SGNSEPKkCLRTRNV intracellular localization 32900932 1 0 1 -CALR Calreticulin ACETYLTRANSFERASE; Acetyltransferase; Calcium-binding; Motility/polarity/chemotaxis; Nuclear receptor co-regulator; Secreted; Secreted, signal peptide P27797 811 19p13.13 human K159-ac 4219807 GKNVLINkDIRCKDD Calreticulin protein conformation 18795239 1 5 2 -RPL11 RPL11 Motility/polarity/chemotaxis; Nucleolus; Ribosomal; Translation P62913 6135 1p36.11 human K19-ne 12067600 MRELRIRkLCLNICV Ribosomal_L5 protein stabilization; intracellular localization 19713960 1 0 0 -HSF1 HSF1 DNA-binding; Transcription factor Q00613 3297 8q24.3 human S292-p 455481 DERPLSSsPLVRVKE Vert_HS_TF transcription, inhibited 25963659 3 5 1 under non-stressed conditions, upon heat shock S to A mutant showed 60% higher luciferase activity -NFE4 NF-E4 Q86UQ8 58160 7q22.1 human K43-ub 486332 DLPLRPRkQATAAGQ protein stabilization; molecular association, regulation; ubiquitination transcription, induced HDAC1(DISRUPTS) 15273251 1 0 0 inhibits NF-E4 ubiquitination -GRIN2A NMDAR2A Channel, ligand-gated; Membrane protein, integral; Membrane protein, multi-pass Q12879 2903 16p13.2 human Y1387-p 455471 GRCPSDPyKHSLPSQ NMDAR2_C activity, induced 10195142; 33037073 6 1 13 potentiation of receptor currents mediated by Src; leptin-induced beta-cell membrane potentiation -CEBPB C/EBP-beta DNA-binding; Motility/polarity/chemotaxis; Transcription factor P17676 1051 20q13.13 human T266-p 448447 VKSKAKKtVDKHSDE molecular association, regulation DNA(INDUCES) 15738002 4 0 0 -LRP1 LRP1 Cell surface; Membrane protein, integral; Motility/polarity/chemotaxis; Receptor, misc. Q07954 4035 12q13.3 human T4460-p 12526700 GFQHQRMtNGAMNVE molecular association, regulation; receptor internalization, altered GULP1(INDUCES); DAB1(INDUCES); SHC1(INDUCES) 15272003 1 4 1 -MVB12A FAM125A Adaptor/scaffold Q96EY5 93343 19p13.11 human Y204-p 469592 LRRNDSIyEASSLYG DUF2464 molecular association, regulation; intracellular localization cytoskeletal reorganization SH3KBP1(INDUCES); CD2AP(INDUCES) 16895919 1 10 58 important for ligand-mediated EGFR internalization and downregulation -CDKN1B p27Kip1 Cell cycle regulation; Inhibitor; Oncoprotein; Protein kinase, regulatory subunit P46527 1027 12p13.1 human Y74-p 475060 HKPLEGKyEWQEVEK CDI protein degradation; molecular association, regulation; phosphorylation cell cycle regulation CDK4(DISRUPTS); CCND1(INDUCES); CDK2(DISRUPTS); CDK4(INDUCES); CCNE1(DISRUPTS) 17254967; 18710949; 21423803; 22276948 10 0 0 -FOXO3 FOXO3A Autophagy; DNA-binding; Oncoprotein; Transcription factor O43524 2309 6q21 human S425-p 2058400 TKGSGLGsPTSSFNS protein degradation; molecular association, regulation; activity, inhibited cell growth, altered MDM2(INDUCES) 18204439 4 10 0 promotes tumorigenicity -Myl9 MRLC1 Contractile; Motility/polarity/chemotaxis Q64122 296313 3q42 rat T19-p 1863501 KKRPQSAtSNVFAMF cytoskeletal reorganization 21887379 28 53 281 T19, S20 di-phosphorylation is recquired for dendritic spine maturation; mono phosphorylation inhibits spine maturation. -G6PD G6PD Carbohydrate Metabolism - pentose phosphate pathway; Cell development/differentiation; EC 1.1.1.49; Other Amino Acids Metabolism - glutathione; Oxidoreductase P11413 2539 Xq28 human K171-ac 3648857 WNRIIVEkPFGRDLQ G6PD_N enzymatic activity, inhibited; enzymatic activity, altered carcinogenesis, inhibited; cell growth, inhibited 33630390; 37798264 2 7 3 K171Q mutant reduces tumor growth when expressed in nude mice. -WAS WASP Adaptor/scaffold; Motility/polarity/chemotaxis P42768 7454 Xp11.23 human K76-sm 52504001 CGAVCFVkDNPQKSY WH1 molecular association, regulation; acetylation transcription, altered; signaling pathway regulation COMMD1(DISRUPTS); HDAC6(DISRUPTS) 26261240 1 0 0 induces hypoacetylation at H3K14, regulates NF-kB signaling -PLA2G4A PLA2G4A EC 3.1.1.4; EC 3.1.1.5; Lipid Metabolism - alpha-linolenic acid; Lipid Metabolism - arachidonic acid; Lipid Metabolism - ether lipid; Lipid Metabolism - glycerophospholipid; Lipid Metabolism - linoleic acid; Phospholipase P47712 5321 1q31.1 human S505-p 447597 LNTSYPLsPLSDFAT PLA2_B activity, induced; intracellular localization; protein conformation; enzymatic activity, induced carcinogenesis, induced; cytoskeletal reorganization; signaling pathway regulation; cell growth, altered KSR(INDUCES) 12885780; 14530366; 18280113; 18632668; 18775330; 19176526; 32559461; 35408744; 36351818; 7766652 25 6 8 required for formation of lipid droplets; regulates mTORC2-PKC?-cPLA2 signaling; PLA2 binding to KSR1 is mediated by ERK . -MLKL MLKL KINASE; Kinase, protein; Protein kinase, Ser/Thr (non-receptor); Protein kinase, TKL Q8NB16 197259 16q23.1 human S358-p 22996309 ELRKTQTsMSLGTTR PK_Tyr_Ser-Thr molecular association, regulation; intracellular localization; protein conformation carcinogenesis, inhibited; apoptosis, induced; transcription, induced; cell motility, inhibited; signaling pathway regulation MLKL(INDUCES) 22265413; 24703947; 26184911; 28758999; 30029665; 34155344 36 3 0 triggers necroptosis in TNBC cells; induces through the necrosis pathway; oligomer formation during necrosis, binds membrane lipids; necroptosis induced -CEBPE C/EBP-epsilon DNA-binding; Motility/polarity/chemotaxis; Transcription factor Q15744 1053 14q11.2 human K121-sm 12004436 DPRAVAVkEEPRGPE activity, induced transcription, induced 12161447; 15661739 2 0 0 -TBC1D1 TBC1D1 DEUBIQUITINASE; GAP; GAP, Rab; Ubiquitin-specific protease Q86TI0 23216 4p14 human T596-p 1247778 AFRRRANtLSHFPIE molecular association, regulation 14-3-3 sigma(INDUCES) 17995453 11 13 137 -C5AR1 C5aR GPCR, family 1; Membrane protein, integral; Membrane protein, multi-pass; Receptor, GPCR P21730 728 19q13.32 human S332-p 448822 EESVVREsKSFTRST molecular association, regulation; receptor desensitization, altered ARRB1(INDUCES); ARRB2(INDUCES) 10636859; 12464600; 17145764 4 8 0 induces translocation of beta-arrestin into the plasma membrane -ATG4B ATG4B Autophagy; EC 3.4.22.-; Protease; Ubiquitin conjugating system Q9Y4P1 23192 2q37.3 human S316-p 2527072 SIAELDPsIAVGFFC Peptidase_C54 molecular association, regulation LC3B(DISRUPTS) 28821708 1 1 0 -KAT2A GCN5 ACETYLTRANSFERASE; Acetyltransferase; EC 2.3.1.48 Q92830 2648 17q21.2 human T272-p 33703200 LNYWKLEtPAQFRQR PCAF_N acetylation; enzymatic activity, induced 24870244 1 0 0 enhanced acetyltransferase acivity, PGC-1a acetylation, suppresses gluconeogenesis -ERBB4 HER4 EC 2.7.10.1; KINASE; Kinase, protein; Membrane protein, integral; Protein kinase, TK; Protein kinase, tyrosine (receptor) Q15303 2066 2q34 human Y1150-p 458100 GELDEEGyMTPMRDK molecular association, regulation Arg(INDUCES); Syk(INDUCES); CRK(INDUCES) 18721752 0 2 4 -Syngap1 SynGAP GAP; GAP, Ras Q9QUH6 192117 20p12 rat S1108-p 8098868 PARPRQQsLSKEGSI DUF3498 molecular association, regulation; intracellular localization PSD-95(DISRUPTS) 25569349 2 2 1 SynGAP dispersion from dendritic spines, Ras activity and GluA1 tafficking during LTP -EGFR EGFR EC 2.7.10.1; KINASE; Kinase, protein; Membrane protein, integral; Oncoprotein; Protein kinase, TK; Protein kinase, tyrosine (receptor) P00533 1956 7p11.2 human K1179-ac 14991103 YQQDFFPkEAKPNGI receptor internalization, induced; phosphorylation endocytosis, induced; signaling pathway regulation 20513767 1 1 0 induces AKT phosphorylation and hence ERK1/2 signaling -JAK2 JAK2 EC 2.7.10.2; KINASE; Kinase, protein; Oncoprotein; Protein kinase, TK; Protein kinase, tyrosine (non-receptor) O60674 3717 9p24.1 human K167-sm 31899102 DFVHGWIkVPVTHET FERM_F2 molecular association, regulation; intracellular localization GH receptor(DISRUPTS) 23581279 1 0 0 translocation into the nucleus -PPP2CA PPP2CA EC 3.1.3.16; Motility/polarity/chemotaxis; PHOSPHATASE; Protein phosphatase, Ser/Thr (non-receptor) P67775 5515 5q31.1 human K136-ac 50286947 FYDECLRkYGNANVW Metallophos enzymatic activity, induced 34740611 1 0 1 -Ptk2b Pyk2 EC 2.7.10.2; KINASE; Kinase, protein; Nuclear receptor co-regulator; Protein kinase, TK; Protein kinase, tyrosine (non-receptor) P70600 50646 15p12 rat Y579-p 447956 RYIEDEDyYKASVTR PK_Tyr_Ser-Thr enzymatic activity, induced 11337490 7 28 947 -SMAD2 SMAD2 DNA-binding; Transcription factor Q15796 4087 18q21.1 human S467-p 447495 SVRCSSMs_______ activity, induced; molecular association, regulation; intracellular localization carcinogenesis, induced; cell differentiation, induced; transcription, induced; transcription, altered TGFBR1(DISRUPTS); SMAD4(INDUCES) 11043574; 21996745; 31995604; 33963314; 35075279; 36461015; 8980228; 9346908; 9346966 57 1 5 S464 not likely phosphorylated but is required for efficient phosphorylation of COOH terminus. -Dab1 DAB1 Adaptor/scaffold Q8CJH2 266729 5q33-q34 rat S491-p 479422 TPAPRQSsPSKSSAS molecular association, regulation CD2AP(DISRUPTS); SH3KBP1(DISRUPTS) 18076569 7 0 0 -Kcna4 Kv1.4 Channel, potassium; Membrane protein, integral; Membrane protein, multi-pass P15385 25469 3q33 rat S229-p 457537 FFDRNRPsFDAILYY BTB_2 intracellular localization 16000151 1 0 1 Kv1.4 with wild-type S229 or S229A had significant difference in current density but not in membrane potential or current shape authors suggest that S229 is important to prevent Kv1.4 from trafficing to the membrane. -TIFA TIFA Q96CG3 92610 4q25 human T9-p 50409900 TSFEDADtEETVTCL activity, induced; molecular association, regulation; ubiquitination; intracellular localization; protein conformation; phosphorylation signaling pathway regulation TIFA(INDUCES); TRAF2(INDUCES); CASP1(INDUCES); TRAF6(INDUCES) 26389808; 27965388; 28069801; 28514661; 28877472; 29581234; 30111836; 36098982 9 1 0 induces IKK and JNK phosphorylation; oligomerization; TIFA oligomerization; activates TRAF6-dependent NF-kB signalling; pThr9 for TIFA oligomerization around DNA damage sites could enhance the efficiency of NEMO ubiquitination upon genotoxic stress.; aggregation; TIFA oligomerization, promote the assembly of NLRP3 inflammasome; p65 translocation and TIFAsome formation; regulates ADP-heptose signaling -SP1 SP1 C2H2-type zinc finger protein; DNA-binding; Transcription factor P08047 6667 12q13.13 human T739-p 448227 SEGSGTAtPSALITT protein degradation; molecular association, regulation; protein stabilization; ubiquitination; intracellular localization; phosphorylation cell differentiation, inhibited; cell cycle regulation; cell growth, inhibited; apoptosis, induced; transcription, induced; transcription, altered; cell growth, induced; transcription, inhibited MYO3A(INDUCES); RNF4(DISRUPTS); ACTB(INDUCES); PIN1(INDUCES) DNA(DISRUPTS) 11904305; 14593115; 14744793; 18199680; 19245816; 19372209; 20150555; 21983342; 22266860; 25398907; 32205409 17 1 0 inhibits transcription of p16, p21 and SDH5; induces phosphorylation at other sites on the protein; reduces binding to FBXL2 promoter -MALT1 MALT1 Adaptor/scaffold; Apoptosis; EC 3.4.22.-; Ligase; Nuclear export; Protease; UBIQUITIN LIGASE; Ubiquitin conjugating system Q9UDY8 10892 18q21.32 human S570-p 1870751202 PIQGTEYsAESLVRN Peptidase_C14 carcinogenesis, induced; cell growth, induced; transcription, induced; signaling pathway regulation 31644910 0 1 0 activates transcription of NF-kB -Kalrn kalirin EC 2.7.11.1; GEF; GEF, Rac/Rho; KINASE; Kinase, protein; Protein kinase, CAMK; Protein kinase, Ser/Thr (non-receptor) P97924 84009 11q22 rat T1572-p 3363402 EPIQLPKtPAKLRNN cell growth, altered 18628310 1 0 1 T1590D mutation increases Trad solubility -Parva PARVA Adaptor/scaffold; Motility/polarity/chemotaxis Q9HB97 57341 1q33 rat S8-p 4270099 MATSPQKsPSVPKSP intracellular localization 30515554 4 33 0 cell morphology changes-found near nucleus dependent on decidualisation -Itpr1 IP3R1 Channel, calcium; Channel, ligand-gated; Membrane protein, integral; Membrane protein, multi-pass P29994 25262 4q41 rat S1756-p 450682 RPSGRREsLTSFGNG activity, induced; receptor inactivation, altered 12167631; 15308649 13 24 15 Mutation of site to Glu enhanced, while mutation to Ala inhibited, calcium release through IP3R1.; increases the open probability of the IP3R receptor Ca(2+) channel -SLC9A5 NHE5 Membrane protein, integral; Membrane protein, multi-pass; Transporter; Transporter, SLC family Q14940 6553 16q22.1 human T714-p 20832302 EESDSSEtEKEDDEG molecular association, regulation; activity, inhibited endocytosis, induced ARRB1(INDUCES) 21296876 1 0 0 -Chuk IKKA EC 2.7.11.10; KINASE; Kinase, protein; Protein kinase, Other; Protein kinase, Ser/Thr (non-receptor) Q60680 12675 19 C3|19 36.71 cM mouse S176-p 447778 AKDVDQGsLCTSFVG Pkinase cell differentiation, inhibited; apoptosis, induced; transcription, induced; transcription, altered 35449211; 35637461; 36309088 34 1 0 -HNRNPA1 hnRNP A1 Nuclear export; RNA splicing; RNA-binding; Spliceosome P09651 3178 12q13.13 human R218-m2 4153100 GGNDNFGrGGNFSGR molecular association, regulation Ebp1(INDUCES); CCND1(INDUCES) 31473880 2 5 18 -RAC1 RAC1 G protein; G protein, monomeric; G protein, monomeric, Rho; Motility/polarity/chemotaxis P63000 5879 7p22.1 human K147-ub 2142500 PQGLAMAkEIGAVKY Ras protein degradation; enzymatic activity, inhibited cell motility, inhibited 18093184; 22614015 3 12 26 -DROSHA DROSHA EC 3.1.26.3; Nucleolus; RNA processing; RNA-binding; Ribonuclease Q9NRR4 29102 5p13.3 human T274-p 25289827 SDYDRGRtPSRHRSY molecular association, regulation DGCR8(DISRUPTS) 25699712 1 1 1 -NCOA6 NCOA6 Nuclear receptor co-regulator; Transcription, coactivator/corepressor Q14686 23054 20q11.22 human S884-p 470103 NKDVTLTsPLLVNLL molecular association, regulation transcription, altered ER-alpha(DISRUPTS); ER-beta(INDUCES) 11773444 1 2 0 S884Y mutation had significant increase in binding to TRB,RXR, and ER-beta, but decreased binding to ER-alpha. Transcriptional activity of S884Y is associated with its receptor binding affinity. S884 may interact with E380 of ER-alpha demonstrated by molecular modeling. -Zc3hav1 ZAP RNA-binding; Transferase Q8K3Y6 252832 4q22 rat S257-p 469059 RDRFLHNsLEFLSPV activity, induced 22514281 1 23 39 -YAP1 YAP1 iso2 Oncoprotein; Transcription, coactivator/corepressor P46937-2 10413 11q22.1 human S127-p 448847 PQHVRAHsSPASLQL activity, induced; protein degradation; molecular association, regulation; intracellular localization; activity, inhibited carcinogenesis, inhibited; cell differentiation, induced; cell growth, inhibited; transcription, inhibited 14-3-3 beta(INDUCES) 19141641; 20048001; 21909427; 23027127; 23752589 207 33 180 -MYL12A MRLC3 Contractile P19105 10627 18p11.31 human Y142-p 11102602 DEEVDELyREAPIDK EF-hand_11 intracellular localization 32502416 1 3 1 -L3MBTL2 L3MBTL2 Histone-binding Q969R5 83746 22q13.2 human K700-sm 31089507 PVSVENIkQETDD__ ubiquitination transcription, inhibited 24369422 2 4 0 induces Histone ubiquitination -MARK2 MARK2 EC 2.7.11.1; EC 2.7.11.26; KINASE; Kinase, protein; Protein kinase, CAMK; Protein kinase, Ser/Thr (non-receptor) Q7KZI7 2011 11q13.1 human T208-p 449999 TFGNKLDtFCGSPPY Pkinase molecular association, regulation; protein conformation; enzymatic activity, induced CBP(DISRUPTS) 22238344; 28711359; 35469920 11 48 47 -AHR AHR DNA-binding; Transcription factor P35869 196 7p21.1 human Y322-p 455230 LCTRGSGyQFIHAAD PAS_3 activity, induced transcription, induced 21703235 2 0 0 Induce AHR activation -PLEKHG1 PLEKHG1 GEF; GEF, Rac/Rho Q9ULL1 57480 6q25.1 human Y661-p 15502837 IDDIDHVyDNISYED activity, induced; molecular association, regulation; intracellular localization cytoskeletal reorganization Fyn(INDUCES) 35031323 1 0 1 -CTNND1 CTNND1 iso3 Actin-binding; Adaptor/scaffold; Cell adhesion; G protein regulator, misc.; Motility/polarity/chemotaxis O60716-3 1500 11q12.1 human S268-p 450453 PQVRVGGsSVDLHRF molecular association, regulation signaling pathway regulation Kaiso(INDUCES); CDH1(DISRUPTS) 21670201 12 73 56 prevents Kaiso binding to Tcf-4 and B-catenin, induces Kaiso binding to CDKN2A promoter, inhibiting CDKN2A gene expression -Tyrobp TYROBP Cell surface; Membrane protein, integral O54885 22177 7 B1|7 17.45 cM mouse Y92-p 451788 IAETESPyQELQGQR molecular association, regulation DOK3(INDUCES) 23962980 1 9 251 -YAP1 YAP1 Oncoprotein; Transcription, coactivator/corepressor P46937 10413 11q22.1 human S109-p 452305 KSHSRQAsTDAGTAG protein degradation; intracellular localization carcinogenesis, altered; cell growth, inhibited; apoptosis, induced; transcription, altered; signaling pathway regulation; cell growth, induced; cell motility, altered; transcription, inhibited; cell growth, altered 24658687; 25660024; 28416665; 33630828; 36588499 23 63 341 regulates AR signaling -PPARG PPAR-gamma iso2 DNA-binding; Nuclear receptor; Transcription factor P37231-2 5468 3p25.2 human S245-p 15175800 TGKTTDKsPFVIYDM protein conformation 25954810 26 2 0 -FEN1 FEN1 DNA repair, damage; DNA-binding; Deoxyribonuclease; EC 3.1.-.-; Nuclear receptor co-regulator; Nucleolus; Ribonuclease P39748 2237 11q12.2 human K168-sm 25724402 ASCAALVkAGKVYAA XPG_I protein degradation; ubiquitination 22749529 1 1 0 -BCL10 Bcl-10 Apoptosis; Transcription, coactivator/corepressor; Tumor suppressor O95999 8915 1p22.3 human S144-p 15408027 NSDESNFsEKLRAST activity, induced 21199863 1 2 1 -DLC1 DLC1 GAP; GAP, Rac/Rho; Tumor suppressor Q96QB1 10395 8p22 human S946-p 37038502 SVSPCPSsPKQIHLD activity, induced; intracellular localization; protein conformation carcinogenesis, inhibited; cell growth, inhibited; cell motility, inhibited talin 1(INDUCES); tensin 1 iso1(INDUCES) 25452387 1 1 0 localize to focal adhesions; activates Rho-GAP activity -Kif3a KIF3A Microtubule-binding; Motor P28741 16568 11 B1.3|11 31.97 cM mouse S698-p 50247605 KPETVIDsLLQ____ activity, induced; molecular association, regulation CDH2(INDUCES) 26335646 1 1 0 enhances N-cadhedrin transport and affects synapse formation -Trim25 TRIM25 EC 6.3.2.19; EC 6.3.2.n3; Ligase; Nuclear receptor co-regulator; Transcription factor; UBIQUITIN LIGASE; Ubiquitin conjugating system; Ubiquitin ligase Q61510 217069 11|11 C mouse S12-p 1868624700 NPLAEELsCSVCLEL protein stabilization carcinogenesis, inhibited 32576271 2 0 0 -HTT Huntingtin Cytoskeletal P42858 3064 4p16.3 human S16-p 12056100 KAFESLKsFQQQQQQ receptor internalization, induced; molecular association, regulation; intracellular localization; protein conformation apoptosis, inhibited; cytoskeletal reorganization HMGB1(INDUCES); Huntingtin(INDUCES); Huntingtin(DISRUPTS); Exportin-1(DISRUPTS) 21623356; 23297360; 24334607; 24505464; 28698602; 30185623; 30538129; 33256402 18 2 0 -Kdr VEGFR2 EC 2.7.10.1; KINASE; Kinase, protein; Membrane protein, integral; Protein kinase, TK; Protein kinase, tyrosine (receptor) P35918 16542 5 C3.3|5 40.23 cM mouse S1191-p 18755301 MEEDSGLsLPTSPVS protein degradation; molecular association, regulation; ubiquitination BTRC(INDUCES) 21402774 1 0 0 -ARRB2 ARRB2 Adaptor/scaffold P32121 409 17p13.2 human Y250-p 1883582902 CLFSTAQyKCPVAQL Arrestin_C activity, induced; molecular association, regulation; protein conformation carcinogenesis, induced RKHD4(INDUCES); IGF1R(INDUCES) 37521868 1 0 0 -RAB1A RAB1A G protein; G protein, monomeric; G protein, monomeric, Rab P62820 5861 2p14 human T75-p 1247157 AGQERFRtITSSYYR Ras activity, induced; molecular association, regulation; intracellular localization GDI1(DISRUPTS) 27482120 1 10 20 membrane localization, ER to Golgi vesicle transport and in maintaining proper Golgi structure -Kcnd2 Kv4.2 Channel, potassium; Membrane protein, integral; Membrane protein, multi-pass Q63881 rat K437-sm 1879723000 LARIRAAkSGSANAY intracellular localization 31213982 2 0 0 increase in Kv4.2 surface expression -Cad CAD Amino Acid Metabolism - alanine, aspartate and glutamate; EC 2.1.3.2; EC 3.5.2.3; EC 6.3.5.5; Hydrolase; KINASE; Ligase; Nucleotide Metabolism - pyrimidine; Transferase B2RQC6 69719 5|5 B1 mouse S1406-p 451249 GAGGRRLsSFVTKGY MGS carcinogenesis, induced; cell motility, induced; cell growth, induced; apoptosis, inhibited 36122209 4 35 5 -GYS1 GYS1 Carbohydrate Metabolism - starch and sucrose; EC 2.4.1.11; Transferase P13807 2997 19q13.33 human S657-p 449790 RHSSPHQsEDEEDPR Glycogen_syn activity, inhibited 22510711 14 31 20 -NTRK2 TrkB EC 2.7.10.1; KINASE; Kinase, protein; Membrane protein, integral; Protein kinase, TK; Protein kinase, tyrosine (receptor) Q16620 4915 9q21.33 human Y707-p 448812 DVYSTDYyRVGGHTM PK_Tyr_Ser-Thr molecular association, regulation signaling pathway regulation PTP1B(INDUCES) 25288805 13 0 28 -MCM3 MCM3 DNA replication; EC 3.6.4.12 P25205 4172 6p12.2 human K230-ub 58948909 DDLVDKAkPGDRVQV MCM_OB cell cycle regulation 27621311 1 1 0 KEAP1-MCM3 associates with chromatin in a cell cycle-dependent manner -Ccdc141 CCDC141 Unknown function E9Q8Q6 545428 2|2 C3 mouse T91-p 1874043200 LLREADRtAEANKAQ protein degradation cell motility, induced 34298015 1 0 0 -Nde1 NUDE1 Cell cycle regulation; Cytoskeletal; Microtubule-binding Q9CZA6 67203 16|16 A1 mouse Y90-p 912008302 EMQHSEGyRQISALE molecular association, regulation PAFAH1B1(DISRUPTS) 29562183 1 1 0 -PRKN PARK2 EC 6.3.2.-; EC 6.3.2.19; Ligase; Translation; Translation regulation; UBIQUITIN LIGASE; Ubiquitin conjugating system; Ubiquitin ligase O60260 5071 6q26 human S65-p 25538008 NCDLDQQsIVHIVQR ubiquitin protein degradation; molecular association, regulation; ubiquitination; intracellular localization; protein conformation; enzymatic activity, induced carcinogenesis, inhibited; autophagy, induced; cell growth, inhibited; autophagy, inhibited ubiquitin(INDUCES); PARK2(INDUCES) 22724072; 23256036; 23754282; 23953109; 24660806; 24671417; 24751536; 24784582; 25375667; 25474007; 26161729; 26254305; 26631732; 31112535; 33730565; 34166935; 36480196 34 10 0 induces mitophagy; induced mitophagy; S65A mutation inhibits PARK2 mitochondrial translocation; PINK1-mediated activation via phosphorylation of of PARK2 at S65 ; induces FAT10ylation of itself and mitofusin2 thus inducing their ubiquitylation and degradation; interaction between the R1 domain and the UBL domain, localized to mitochondria; phosphorylation of PARK2 disrupts the Ubl RING1 interaction, p-ubiquitin S65 binds to a patch on PARK2 RING1 domain -Alyref2 Refbp2 DNA-binding; RNA-binding Q9JJW6 56009 1|1 H3 mouse R188-m2 13906408 RGSQGRGrGTGRNSK FoP_duplication molecular association, regulation RNA(DISRUPTS) 20129943 1 1 0 -SOD2 SOD2 EC 1.15.1.1; Mitochondrial; Oxidoreductase P04179 6648 6q25.3 human K122-me 1872904400 GELLEAIkRDFGSFD Sod_Fe_C cell cycle regulation 22710435 1 1 0 quiescent fibroblasts are dimethylated at K122, and R197 and are also dimethylated in proliferating cells -IQCB1 IQCB1 Cell development/differentiation Q15051 9657 3q13.33|3q21.1 human K19-ub 95155302 SIAAEVAkSPEQNVP intracellular localization cell cycle regulation; cytoskeletal reorganization 28498859 1 3 0 regulation of cilia formation -KIF22 KIF22 Microtubule-binding; Motor Q14807 3835 16p11.2 human T134-p 30993022 GPTGAGKtHTMLGSP Kinesin intracellular localization 35730929 1 2 0 -CYCS CYCS Apoptosis; Mitochondrial; Oxidoreductase; PHOSPHATASE; Protein phosphatase, Ser/Thr (non-receptor) P99999 54205 7p15.3 human Y98-p 469603 ERADLIAyLKKATNE Cytochrom_C protein degradation; molecular association, regulation; enzymatic activity, induced apoptosis, inhibited COX1(INDUCES); HIGD1A(DISRUPTS) 21706253; 30018060 2 8 73 regulates electron donating rate of CYCS, induces activity of COX1, decreases ROS production inducing neuronal survival under ischemia damage -Ppara PPAR-alpha DNA-binding; Nuclear receptor; UBIQUITIN LIGASE P37230 25747 7q34 rat S110-p 457547 RICGDKAsGYHYGVH zf-C4 activity, induced transcription, altered 16042408 1 0 0 -Pparg PPAR-gamma iso2 DNA-binding; Nuclear receptor; Transcription factor P37238-2 19016 6 E3|6 53.41 cM mouse K432-ub 40190210 ESSQLFAkVLQKMTD Hormone_recep protein degradation transcription, inhibited 24072712 1 0 0 -UBA2 SAE2 EC 6.3.2.-; EC 6.3.2.19; Ligase; Motility/polarity/chemotaxis; SUMO LIGASE; SUMO conjugating system; SUMO ligase; UBIQUITIN LIGASE; Ubiquitin conjugating system; Ubiquitin ligase Q9UBT2 10054 19q13.11 human K617-sm 27851105 RKRKLDEkENLSAKR UBA2_C intracellular localization 23095757 1 2 0 nuclear localization -KNL1 CASC5 Cancer Testis Antigen (CTA); Cell cycle regulation Q8NG31 57082 15q15.1 human S60-p 459643 KKNSRRVsFADTIKV phosphorylation cell cycle regulation 25402682 3 31 6 -GIT1 GIT1 GAP; GAP, ARF; Motility/polarity/chemotaxis Q9Y2X7 28964 17q11.2 human S46-p 25784901 RSLGRHIsIVKHLRH ArfGap intracellular localization cell motility, induced; cell adhesion, induced 22893698 1 1 0 -RACK1 RACK1 Adaptor/scaffold; G protein; G protein, heterotrimeric; G protein, heterotrimeric beta; Motility/polarity/chemotaxis; Nuclear receptor co-regulator P63244 10399 5q35.3 human K172-ub 12337352 IVSCGWDkLVKVWNL WD40 protein degradation carcinogenesis, induced 33323973 1 6 17 -Ctnnd2 CTNND2 Actin-binding; Motility/polarity/chemotaxis O35927 18163 15|15 B2 mouse Y1073-p 31014801 ERDRQRPySSSRTPS protein stabilization; molecular association, regulation GSK3B(DISRUPTS) 24412473 1 0 0 increased ability of CTNND2 to enhance the nuclear distribution of B-catenin via E-cadherin -Cdk16 CDK16 Cell cycle regulation; EC 2.7.11.22; KINASE; Kinase, protein; Motility/polarity/chemotaxis; Protein kinase, CMGC; Protein kinase, Ser/Thr (non-receptor) Q04735 18555 X A1.3|X 16.18 cM mouse S78-p 4272751 HEDMKMGsDGESDQA molecular association, regulation CCNYL1(DISRUPTS) 26305884 2 17 1 -SCYL1 SCYL1 KINASE; Kinase, protein; Protein kinase, Other; Protein kinase, Ser/Thr (non-receptor) Q96KG9 57410 11q13.1 human T469-p 33402213 STRHRVLtSAFSRAT intracellular localization carcinogenesis, induced; carcinogenesis, altered 24769208 1 0 0 1) Increase in centrosomal loading of SCYL1 leads to displacement of C-NAP1. 2) Increased centrosomal expression of SCYL1 lead to centrosome splitting and amplification. -ACP1 ACP1 Cofactor and Vitamin Metabolism - riboflavin; EC 3.1.3.2; EC 3.1.3.48; Motility/polarity/chemotaxis; PHOSPHATASE; Phosphatase (non-protein); Protein phosphatase, tyrosine (non-receptor) Q3SZ94 280977 cow Y132-p 450718 QLIIEDPyYGNDADF LMWPc enzymatic activity, induced 10452533 5 15 194 -FZR1 FZR1 UBIQUITIN LIGASE; Ubiquitin conjugating system Q9UM11 51343 19p13.3 human S36-p 3215928 RTLTPASsPVSSPSK protein stabilization 30498084 1 14 2 AURKA stabilization -Hspb6 HSP20 Chaperone; Heat shock protein P97541 192245 1q21 rat S16-p 450706 PSWLRRAsAPLPGFS Crystallin molecular association, regulation apoptosis, inhibited; cytoskeletal reorganization PDE4D(INDUCES) 12663991; 15105294; 21334344 21 31 2 -Fli1 FLI1 DNA-binding; Oncoprotein; Transcription factor P26323 14247 9 A4|9 17.74 cM mouse T312-p 6406002 TNGEFKMtDPDEVAR Ets protein degradation transcription, inhibited 25707716 6 0 0 inhibited transcription of CDH5, PECAM1, PDGFB and MMP9 genes, impaired leaky vessels -MYO6 MYO6 Actin-binding; Motility/polarity/chemotaxis; Motor Q29122 397085 pig T406-p 449089 TAGGAKGtVIKVPLK Myosin_head cytoskeletal reorganization 16917816 4 14 1 T406E mutant clusters vesicles and alters F-actin (increase of filaments and bundled). Motor moves laterally in cell instead of inward. No change in velocity. -UBA52-RPS27A-UBB-UBC ubiquitin Ubiquitin-like modifier P62988 2p16 human K63-ub 486304 LSDYNIQkESTLHLV ubiquitin receptor internalization, induced; protein degradation; protein stabilization; molecular association, regulation; enzymatic activity, inhibited; phosphorylation; enzymatic activity, induced; activity, induced; ubiquitination; intracellular localization cell cycle regulation; carcinogenesis, induced; cell motility, induced; cell adhesion, induced; cell motility, inhibited; signaling pathway regulation; cell growth, induced; DNA repair, inhibited; transcription, inhibited; cell growth, altered; carcinogenesis, inhibited; cell growth, inhibited; transcription, induced; transcription, altered; DNA repair, induced; endocytosis, induced; autophagy, induced; cell differentiation, induced; apoptosis, inhibited CTNNB1(DISRUPTS); Cezanne(INDUCES); TAK1(INDUCES); NPL4(DISRUPTS); LATS1(DISRUPTS); IKKG(INDUCES); TRIM21(INDUCES); CALCOCO2(INDUCES); LC3A(DISRUPTS); PYGO1(DISRUPTS); TAB2(INDUCES); TRAF2(INDUCES); UBL4A(INDUCES) DNA(DISRUPTS) 11460167; 18212250; 18326498; 18613717; 19854138; 19854139; 19858201; 19935683; 21102657; 26471729; 28458162; 29378950; 30918126; 30929559; 30931944; 31042464; 31070797; 31073027; 31127032; 31182807; 31269432; 31451677; 31619538; 31902824; 31937588; 31999304; 32051553; 32453758; 32679077; 33067265; 33196940; 33710666; 35064336; 35100065; 35110531; 35316220; 35503863; 35792897; 35853811; 35856559; 35864951; 35918322; 35938958; 36088509; 36115849; 36289618; 36473924; 37027301; 37330913; 37450367 121 39 155 K139 ubiquitylation promotes cell proliferation and motility-migration and metastasis; GPR108 interacts with Smurf1, followed by the recruitment of IRF3 during viral infection; TRIM21 affected the expression of the target genes of NF-kB R but not in PPDPF knockdown cells ; GPR108 and Smurf1 mediated degradation requires NDP52; K139 is critical for its binding to TRAF2 and activation of the NF-kB pathways leading to proliferation and migration; NDP52-dependent autophagic degradation of phosphorylated IRF3; autoamplifcation of NFAT-c1, which promotes osteoclast differentiation, suppressed by MLN4924; formation of CPC complex, required for proper mitotic progression, critical site for cell survival -Cry2 CRY2 DNA-binding; Lyase Q9R194 12953 2|2 E1 mouse K503-ub 27717312 RLNIERMkQIYQQLS FAD_binding_7 protein degradation; intracellular localization 23452856 1 3 0 -Syn1 SYN1 Vesicle P09951 24949 Xq11 rat S67-p 451573 VASPAAPsPGSSGGG neural plasticity 33519375; 35723394 16 11 1 -SCN5A SCN5A Channel, sodium; Membrane protein, integral; Membrane protein, multi-pass Q14524 6331 3p22.2 human S667-p 25752820 QRALSAVsVLTSALE Na_trans_cytopl activity, induced; protein conformation 33410863 3 5 1 -Trpm7 ChaK1 Channel, cation; EC 2.7.11.1; KINASE; Kinase, protein; Membrane protein, integral; Membrane protein, multi-pass; Protein kinase, Ser/Thr (non-receptor); Protein kinase, atypical Q923J1 58800 2|2 F1 mouse D1510-ca 57858700 TEDSPEVdSKAALLP activity, induced apoptosis, induced 22698280 1 0 0 increase channel current -Clcn3 CLCN3 iso2 Channel, chloride; Membrane protein, integral; Membrane protein, multi-pass; Transporter; Transporter, ion channel; Vesicle P51792-2 84360 rat T532-p 51381106 LGGVTRMtVSLVVIV Voltage_CLC cell motility, induced 26562480 1 0 0 AngII-induced Cl- current and VSMC migration, AngII-induced hypertensive vascular remodeling -HK1 HK1 Carbohydrate Metabolism - amino sugar and nucleotide sugar; Carbohydrate Metabolism - fructose and mannose; Carbohydrate Metabolism - galactose; Carbohydrate Metabolism - glycolysis and gluconeogenesis; Carbohydrate Metabolism - starch and sucrose; EC 2.7.1.1; Kinase, other; Mitochondrial P19367 3098 10q22.1 human S124-p 55569800 NIVHGSGsQLFDHVA Hexokinase_1 enzymatic activity, induced 27153534 1 1 0 -CDCP1 CDCP1 Cell surface; Membrane protein, integral Q9H5V8 64866 3p21.31 human Y762-p 455577 LQPEVDTyRPFQGTM molecular association, regulation cell growth, induced PKCD(INDUCES) 15851033; 23300860 3 1 2 -CELF1 CELF1 Cell development/differentiation; RNA processing; RNA-binding Q92879 10658 11p11.2 human S300-p 29668005 VLTSSGSsPSSSSSN RNA splicing, altered 24151077 1 1 0 splicing regulation in diabetes -CASP6 CASP6 Apoptosis; EC 3.4.22.59; Protease P55212 839 4q25 human C277-pa 60885601 IGKKQVPcFASMLTK Peptidase_C14 molecular association, regulation; enzymatic activity, inhibited; protein conformation 27911442 1 0 0 Palmitoylation inhibits CASP6 activity by blocking substrate binding site and dimerization. -HDAC2 HDAC2 DEACETYLASE; Deacetylase; EC 3.5.1.98; Nuclear receptor co-regulator; Transcription, coactivator/corepressor Q92769 3066 6q21 human S424-p 467980 CDEEFSDsEDEGEGG acetylation; molecular association, regulation; enzymatic activity, inhibited p53(INDUCES); HDAC1(INDUCES); KLF4(DISRUPTS) 19486889; 20388487 4 73 49 -Cs CS Carbohydrate Metabolism - citrate (TCA) cycle; Carbohydrate Metabolism - glyoxylate and dicarboxylate; EC 2.3.3.1; Mitochondrial; Transferase Q9CZU6 12974 10|10 D3 mouse S225-p 4774521 RNLYREGsSIGAIDS Citrate_synt enzymatic activity, inhibited 31628154 1 3 2 -Kcnd2 Kv4.2 Channel, potassium; Membrane protein, integral; Membrane protein, multi-pass Q9Z0V2 16508 6 A2-A3.1|6 8.49 cM mouse S552-p 450462 VSGSHRGsVQELSTI activity, induced 31311860 6 8 0 -CCNO CCNO Cell cycle regulation; DNA repair, damage; EC 3.2.2.-; Hydrolase P22674 10309 5q11.2 human S81-p 7445148 PSAARGGsPLPGPAQ enzymatic activity, induced 25364462 1 11 0 stimulates CDK2 kinase activity -HNRNPA1 hnRNP A1 Nuclear export; RNA splicing; RNA-binding; Spliceosome P09651 3178 12q13.13 human S199-p 451555 SQRGRSGsGNFGGGR molecular association, regulation; activity, inhibited cell cycle regulation; carcinogenesis, inhibited; cell differentiation, induced; cell growth, inhibited; translation, inhibited CHIP(INDUCES); FOXP3(INDUCES) 18562319; 21454539; 34080184 6 9 8 -RCJMB04_5k17 CARD11 Adaptor/scaffold Q5F3W0 416476 chicken S578-p 457640 NRNDSIMsTTPEPPG activity, induced; molecular association, regulation Bcl-10(INDUCES); MALT1(INDUCES) 18086859; 24833394 5 0 0 switchlike activation of NF-kB -MYC Myc DNA-binding; Nucleolus; Oncoprotein; Transcription factor P01106 4609 8q24.21 human S362-p 466010 RKCTSPRsSDTEENV carcinogenesis, inhibited; transcription, inhibited 24030976 3 1 0 -MFF MFF Membrane protein, integral; Mitochondrial Q9GZY8 56947 2q36.3 human S172-p 484865 GQLVRNDsLWHRSDS Miff ubiquitination cell cycle regulation; carcinogenesis, inhibited; autophagy, induced; cell growth, inhibited; cell growth, induced 34010649; 36481655 6 54 13 -PLK2 PLK2 EC 2.7.11.21; KINASE; Kinase, protein; Protein kinase, Other; Protein kinase, Ser/Thr (non-receptor); Tumor suppressor Q9NYY3 10769 5q11.2 human S358-p 1883594400 VPDFHLSsPAKNFFK protein stabilization; phosphorylation; enzymatic activity, induced carcinogenesis, induced; cell motility, induced; cell growth, induced 37387444 1 0 0 induces SNCA phosphorylation -NRL NRL DNA-binding; Transcription factor P54845 4901 14q11.2-q12 human S117-p 1880112600 PHGYYPGsPEETGAQ transcription, inhibited 36226585 1 0 0 -RFX1 RFX1 DNA-binding P22670 5989 19p13.12 human S120-p 452650 SETVSEAsPGSTASQ transcription, inhibited 26041775 1 3 0 -STK26 MST4 EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, STE; Protein kinase, Ser/Thr (non-receptor) Q9P289 51765 Xq26.2 human T327-p 4270933 THPEWSFtTVRKKPD molecular association, regulation carcinogenesis, induced; cell motility, induced MOB1A(INDUCES) 30072378 1 4 8 -EIF4EBP1 4E-BP1 Translation; Translation initiation Q13541 1978 8p11.23 human T50-p 3195728 FSTTPGGtRIIYDRK eIF_4EBP phosphorylation cell growth, induced; translation, induced EIF4E(DISRUPTS) 23584478; 24247720 2 20 38 T41 and T50 act as priming sites for T37/46; T41A and T50A mutants inhibited tumor growth and showed more cap-binding. -MAF MAF Cell development/differentiation; DNA-binding; Oncoprotein; Transcription factor; Tumor suppressor O75444 4094 16q23.2 human S15-p 487502 SNSDLPTsPLAMEYV transcription, altered 17897790 1 0 0 sites behave in a dramatic cell type-specific manner -Pygl PYGL Carbohydrate Metabolism - starch and sucrose; EC 2.4.1.1; Transferase Q9ET01 110095 12 C2|12 29.01 cM mouse K796-ac 23003809 SQLYMNQkAWNTMVL Phosphorylase enzymatic activity, inhibited; phosphorylation PPP1CA(INDUCES) 22225877 1 0 0 acetylation enhances its interaction with the PPP1CA substrate-targeting PL, promoting PYGL dephosphorylation -Cftr CFTR Channel, chloride; EC 3.6.3.49; Hydrolase; Membrane protein, integral; Membrane protein, multi-pass; Transporter; Transporter, ABC family P26361 12638 6 A2|6 8.1 cM mouse T1467-p 21440502 ITALKEEtEEEVQET protein degradation 24058532 2 1 0 protein destabilization -SIRT1 SIRT1 Apoptosis; DEACETYLASE; Deacetylase; EC 3.5.1.-; Nuclear receptor co-regulator Q96EB6 23411 10q21.3 human S27-p 452898 ADREAASsPAGEPLR activity, induced; acetylation; protein stabilization; ubiquitination; intracellular localization; enzymatic activity, induced carcinogenesis, induced; cell motility, induced; cell growth, induced; transcription, induced; signaling pathway regulation 20027304; 23754392; 34826187 5 19 1 inhibits ubiquitination of itself, induces deacetylation of Snail to increase the production of IL-6/IL8; expression and regulation of SIRT1 target antioxidative and anti-inflammatory genes increased -HMGB1 HMGB1 DNA repair, damage; Nuclear receptor co-regulator P09429 3146 13q12.3 human S35-p 476055 KKKHPDAsVNFSEFS HMG_box_2 intracellular localization cell motility, altered 19506549; 23782844 3 23 3 increases tumor cell invasiveness -HSPA5 GRP78 Chaperone; Heat shock protein; KINASE P11021 3309 9q33.3 human T69-p 55370298 TPSYVAFtPEGERLI HSP70 protein stabilization; molecular association, regulation carcinogenesis, induced; cell growth, induced; apoptosis, inhibited TRIM21(DISRUPTS) 36042349 1 2 0 inhibits ubiquitination -Traf6 TRAF6 EC 6.3.2.-; Ligase; UBIQUITIN LIGASE; Ubiquitin conjugating system; Ubiquitin ligase P70196 22034 2|2 E2 mouse T494-p 34362608 LEALRQGtFIKDDTL ubiquitination; protein conformation transcription, inhibited 25642822 1 0 1 prevent its oligomerization and autoubiquitination, inhibits LPS-stimulated transcription of Tnf and Il6 -AKT1 Akt1 EC 2.7.11.1; KINASE; Kinase, protein; Oncoprotein; Protein kinase, AGC; Protein kinase, Ser/Thr (non-receptor) P31749 207 14q32.33 human K142-m3 1879848301 EVSLAKPkHRVTMNE enzymatic activity, induced carcinogenesis, induced; cell motility, induced JMJD2B(INDUCES); JMJD2A(INDUCES); PDK1(INDUCES); TRAF6(INDUCES) 30692625 1 1 0 interaction of Akt1 with TRAF6, and subsequent Akt ubiquitination ; promotes cell growth and glycolysis -Crkl CRKL Adaptor/scaffold; Motility/polarity/chemotaxis P47941 12929 16|16 A3 mouse Y207-p 447954 IPEPAHAyAQPQTTT carcinogenesis, induced; cell growth, induced; apoptosis, inhibited; signaling pathway regulation 22169110 15 20 1215 RAF-MEK-ERK pathway -WWTR1 TAZ Oncoprotein; Transcription, coactivator/corepressor Q9GZV5 25937 3q25.1 human S93-p 3211887 RSHSSPAsLQLGTGA molecular association, regulation; intracellular localization 14-3-3 beta(DISRUPTS) 33086783 1 7 9 -IKBKG IKKG Adaptor/scaffold; Protein kinase, regulatory subunit Q9Y6K9 8517 Xq28 human S377-p 3217806 PAPAYLSsPLALPSQ enzymatic activity, inhibited; phosphorylation signaling pathway regulation 23131831 1 5 53 modulates IFKB phosphorylation; regulation of TCR mediated calcium (Ca2+) influx; NF-kB pathway -RXRA RXRA DNA-binding; Motility/polarity/chemotaxis; Nuclear receptor P19793 6256 9q34.2 human S32-p 456811 RGSMAAPsLHPSLGP Nuc_recep-AF1 molecular association, regulation; activity, inhibited transcription, inhibited SRC-1(DISRUPTS) 16184197; 20432439 2 0 0 -ECT2 ECT2 GEF; GEF, Rac/Rho; Motility/polarity/chemotaxis Q9H8V3 1894 3q26.31 human T444-p 457522 TKSSKSStPVPSKQS activity, induced; molecular association, regulation transcription, altered PLK1(INDUCES) 16247472 2 3 11 phosphorylation important for RhoA activation -FANCD2 FANCD2 DNA repair, damage Q9BXW9 2177 3p25.3 human T896-p 27448950 KNSECDPtPSHRGQL FancD2 molecular association, regulation; ubiquitination; intracellular localization; activity, inhibited cell cycle regulation; DNA repair, inhibited; signaling pathway regulation DNA(DISRUPTS) 31167143 1 4 0 inhibits Fanconi anemia pathway leading to inhibition of DNA repair; 882-898 cluster -RPS10 RPS10 Nucleolus; RNA-binding; Ribosomal; Translation P46783 6204 6p21.31 human R160-me 13906403 RGGFGRGrGQPPQ__ protein stabilization; molecular association, regulation; intracellular localization NPM1(INDUCES) 20159986 1 0 0 localization in the granular component (GC) region of the nucleolus; efficient assembly of RPS10 into ribosomes and protein synthesis -Lrrk2 LRRK2 EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, Ser/Thr (non-receptor); Protein kinase, TKL Q5S006 66725 15|15 E3 mouse S973-p 4725913 SHMRQSDsSSSLASE enzymatic activity, inhibited autophagy, induced 37454104 14 13 0 -NCF1 p47phox EC 1.-.-.-; Oxidoreductase P14598 653361 7q11.23 human S304-p 449406 GAPPRRSsIRNAHSI NECFESHC activity, induced; molecular association, regulation; intracellular localization; enzymatic activity, induced cell growth, induced; signaling pathway regulation CYBA(INDUCES) 10559253; 12056906; 20920494; 31736979; 33139577; 35108370 17 0 0 induces ROS production; LPS-induced activation of p38MAPK and ERK1/2 signaling pathways -MAP4K1 HPK1 EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, STE; Protein kinase, Ser/Thr (non-receptor) Q92918 11184 19q13.2 human T175-p 4198300 RRLSFIGtPYWMAPE Pkinase protein degradation; enzymatic activity, induced transcription, altered 15743830; 24362026 2 1 3 -AQP1 AQP1 Membrane protein, integral; Membrane protein, multi-pass; Transporter; Transporter, aquaporin family P29972 358 7p14.3 human T239-p 482807 APRSSDLtDRVKVWT activity, induced; intracellular localization 17522053; 22334691 2 0 0 T157A/T239A double mutation inhibits AQP1 translocation to the plasma membrane following hypotonic exposure; phosphorylation by PKC increases ion currents and water permability of AQP1. -NOTCH1 Notch 1 Membrane protein, integral; Motility/polarity/chemotaxis; Oncoprotein; Receptor, misc.; Transcription factor P46531 4851 9q34.3 human T1897-p 20831303 CSGGGLEtGNSEEEE molecular association, regulation; activity, inhibited transcription, induced; transcription, inhibited RBPJ(INDUCES) DNA(DISRUPTS) 21685388; 24220241 2 0 0 -NFKB1 NFkB-p105 DNA-binding; Transcription factor P19838 4790 4q24 human S328-p 22771100 INITKPAsVFVQLRR RHD_dimer molecular association, regulation transcription, inhibited DNA(DISRUPTS) 22152481; 23180782 4 1 0 -FOXO1 FOXO1A DNA-binding; Nuclear receptor co-regulator; Oncoprotein; Transcription factor Q12778 2308 13q14.11 human S418-p 478369 NTSLNSPsPNYQKYT intracellular localization transcription, altered 20061393 4 1 0 multiple site mutant (8A) -KCNK9 KCNK9 Membrane protein, integral; Membrane protein, multi-pass Q9NPC2 51305 8q24.3 human S373-p 18609100 RLMKRRKsV______ activity, induced; intracellular localization 21357689 1 0 0 -XIAP XIAP Apoptosis; EC 6.3.2.-; Ligase; UBIQUITIN LIGASE; Ubiquitin conjugating system; Ubiquitin ligase P98170 331 Xq25 human K322-ub 22547401 DPWEQHAkWYPGCKY BIR protein degradation 22072751 1 1 0 -CSF3R GCSFR Membrane protein, integral; Receptor, cytokine Q99062 1441 1p34.3 human K704-ub 9381806 TVLEEDEkKPVPWES receptor internalization, induced; protein degradation; intracellular localization; phosphorylation carcinogenesis, inhibited; cell growth, inhibited; signaling pathway regulation 19453968; 28439110 2 0 0 regulates production of neutrophilic granulocytes, regulates STAT5 activation; inhibited STAT5 activation -SPRY1 SPRY1 Adaptor/scaffold; Inhibitor; Motility/polarity/chemotaxis O43609 10252 4q28.1 human Y53-p 454589 AIRGSNEyTEGPSVV molecular association, regulation; phosphorylation carcinogenesis, inhibited; signaling pathway regulation GRB2(INDUCES) 32188694 3 18 234 inhibits Ras-mediated ERK1/2 and AKT phosphorylation and pathways -Jun Jun Oncoprotein; Transcription factor P17325 24516 5q33 rat S63-p 447686 KNSDLLTsPDVGLLK Jun activity, induced; protein stabilization transcription, altered; cell growth, altered 12169099; 1749429 133 43 4 -SOD1 SOD1 Apoptosis; EC 1.15.1.1; Mitochondrial; Nuclear receptor co-regulator; Oxidoreductase P00441 6647 21q22.11 human K123-ac 11317132 RTLVVHEkADDLGKG Sod_Cu intracellular localization 28739857 2 8 2 mitochondrial localization, inihibits SOD1-mediated suppression of mitochondrial respiration -Irf4 IRF4 DNA-binding; Oncoprotein; Transcription factor Q64287 16364 13|13 A3.2 mouse S447-p 12265165 HRSLRHSsIQE____ cell differentiation, induced; transcription, induced DNA(INDUCES) 20697158 1 1 0 production of IL-17 and IL-21 -LRRK1 LRRK1 EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, Ser/Thr (non-receptor); Protein kinase, TKL Q38SD2 79705 15q26.3 human S1064-p 15411924 NRKVTIYsFTGNQRN phosphorylation; enzymatic activity, induced 36040231 1 1 1 induces Rab7 phosphorylation -DVL3 DVL3 Motility/polarity/chemotaxis Q92997 1857 3q27.1 human S697-p 4729017 VPPELTAsRQSFRMA Dsh_C intracellular localization 27486244 2 4 0 centrosomal signal for pS697 accumulated throughout the cell cycle, pS280 only in mitotic spindle and not in the interphase centrosome -TP63 p63 iso2 DNA-binding; Transcription factor Q9H3D4-2 8626 3q28 human S368-p 34504455 SPSSYGNsSPPLNKM molecular association, regulation DNA(INDUCES) 34761935 0 2 0 -FBXW7 FBXW7 Motility/polarity/chemotaxis; Nucleolus; UBIQUITIN LIGASE; Ubiquitin conjugating system; Ubiquitin ligase Q969H0 55294 4q31.3 human S227-p 17792400 QQRRRITsVQPPTGL protein degradation; protein stabilization; ubiquitination apoptosis, induced; transcription, altered 21620836 2 0 0 -Nrip1 RIP140 Nuclear receptor co-regulator; Transcription, coactivator/corepressor Q8CBD1 268903 16|16 C3.1 mouse K778-me 6742803 LPLNHDAkSAPFLGV NRIP1_repr_3 molecular association, regulation; methylation transcription, inhibited HDAC3(INDUCES) 19216533 1 1 0 inhibits arginine methylation -YAP1 YAP1 Oncoprotein; Transcription, coactivator/corepressor P46937 10413 11q22.1 human K321-ub 603486522 EKERLRLkQQELLRQ activity, induced; protein degradation; ubiquitination; intracellular localization carcinogenesis, inhibited; apoptosis, induced; cell motility, inhibited 29891922; 33939216; 36280829 3 2 0 -BECN1 beclin 1 Adaptor/scaffold; Autophagy; Membrane protein, peripheral Q14457 8678 17q21.31 human S90-p 472001 IPPARMMsTESANSF molecular association, regulation; ubiquitination carcinogenesis, induced; carcinogenesis, inhibited; autophagy, induced; cell differentiation, induced; cell growth, inhibited; apoptosis, induced; signaling pathway regulation Bcl-2(DISRUPTS); SLC7A11(INDUCES); PIK3C3(NOT_REPORTED) 23878393; 25693418; 26994142; 29079782; 30057310; 31220095; 31696776; 32187724; 34851698 10 4 10 -KRT20 K20 Cytoskeletal P35900 54474 17q21.2 human S13-p 463823 RSFHRSLsSSLQAPV apoptosis, induced 16608857 3 7 0 promotes keratin filaments disassembly -Tlr4 TLR4 Membrane protein, integral; Receptor, misc. Q9QUK6 21898 4 C1|4 34.66 cM mouse Y672-p 478360 YSRGESIyDAFVIYS TIR phosphorylation transcription, induced; signaling pathway regulation 37058370 3 1 0 -INPP5D SHIP iso2 EC 3.1.3.86; Motility/polarity/chemotaxis; Phosphatase, lipid Q92835-2 3635 2q37.1 human S933-p 4778416 LHVKQTLsPDQQPTA intracellular localization 29852247 2 9 0 nucleocytoplasmic shuttling (A mutant reduced accumulation in nucleus) -EPHB2 EphB2 EC 2.7.10.1; KINASE; Kinase, protein; Membrane protein, integral; Protein kinase, TK; Protein kinase, tyrosine (receptor); Tumor suppressor P29323 2048 1p36.12 human K891-ub 1881446405 IRNPNSLkAMAPLSS molecular association, regulation autophagy, induced MAP1LC3B2(INDUCES) 33280498 1 1 0 -Gapvd1 GAPVD1 GAP; GAP, Ras; GEF; GEF, Rab; Vesicle Q6PAR5 66691 2|2 B mouse S902-p 468085 ERLVRSRsSDIVSSV endocytosis, inhibited 30772465 1 67 87 phosphorylation of this site reduces endocytosis of LDL -Scnn1a ENaC-alpha Channel, sodium; Membrane protein, integral; Membrane protein, multi-pass; Transporter, ion channel P37089 25122 4q42 rat S621-p 454020 RFRSRYWsPGRGARG activity, induced; intracellular localization; phosphorylation 15234985; 21220922; 35525869 4 0 0 primes phosphorylation at S617 -PYGB PYGB Carbohydrate Metabolism - starch and sucrose; EC 2.4.1.1; Kinase, other; Phosphorylase; Transferase P11216 5834 20p11.21 human S15-p 456885 SEKRKQIsVRGLAGL signaling pathway regulation 21668450 4 17 1 regulation of glycogen synthesis via R3F-PP1 signaling in astrocytoma cells -PPP1R12A MYPT1 Motility/polarity/chemotaxis; PHOSPHATASE; Protein phosphatase, regulatory subunit O14974 4659 12q21.2-q21.31 human S589-gl 1868585002 LQKSLLSsTSTTTKI molecular association, regulation; phosphorylation cell cycle regulation PLK1(DISRUPTS) 32295844 1 1 0 inhibits CDK1-dependent phosphorylation at MYPT1 S473, regulates mitotic progression and centrosome integrity -RAC1 RAC1 G protein; G protein, monomeric; G protein, monomeric, Rho; Motility/polarity/chemotaxis P63000 5879 7p22.1 human S71-p 447994 YDRLRPLsYPQTDVF Ras protein degradation; activity, inhibited 10617634; 23512198 6 3 6 Akt induces Rac1 degradation via S71 phosphorylation; Phosphorylation of this site inhibits GTP binding activity of Rac1 without affecting its GTPase activity. -Kcnk2 TREK-1 Channel, potassium; Membrane protein, integral; Membrane protein, multi-pass P97438 16526 1|1 H6 mouse S348-p 456161 KETRRRLsVEIYDKF activity, induced; activity, inhibited cytoskeletal reorganization 10835347; 11319556; 15976821; 16006563; 17916432 8 5 0 -CLIP1 Restin iso3 Cytoskeletal P30622-2 6249 12q24.31 human S195-p 468616 LTKTASEsISNLSEA protein stabilization; intracellular localization cell cycle regulation; carcinogenesis, induced; apoptosis, inhibited; transcription, altered 23661607 2 56 33 induce AR stabilization and nuclear translocation/accumulation -kif2c KIF2C Cancer Testis Antigen (CTA); Microtubule-binding; Motility/polarity/chemotaxis; Motor Q91636 380006 frog S196-p 2132102 NNQGRRKsNIVKEME molecular association, regulation; intracellular localization; protein conformation; activity, inhibited cytoskeletal reorganization TUBB1(DISRUPTS) DNA(DISRUPTS) 17567953; 18434591; 24291095 5 2 25 -DGCR8 DGCR8 Nucleolus; RNA processing; RNA-binding Q8WYQ5 54487 22q11.21 human S677-p 1874101914 RVGKQLAsQKILQLL dsrm protein stabilization; molecular association, regulation; ubiquitination; intracellular localization DNA repair, induced USP51(INDUCES) 34188037 1 1 0 induces deubiquitination of itself and promotes histone ubiquitination -RPS6KB2 P70S6KB EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, AGC; Protein kinase, Ser/Thr (non-receptor); Translation Q9UBS0 6199 11q13.2 human S423-p 455991 SSPRAPVsPLKFSPF enzymatic activity, induced 11108720 2 18 44 -RPS6KA4 MSK2 EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, AGC; Protein kinase, Ser/Thr (non-receptor) O75676 8986 11q13.1 human S343-p 450045 TRLEPVYsPPGSPPP Pkinase_C enzymatic activity, induced 10806207 1 34 5 -Canx Calnexin Calcium-binding; Endoplasmic reticulum; Membrane protein, integral; Motility/polarity/chemotaxis P35564 12330 11 B1.3|11 30.46 cM mouse S563-p 456360 EEDGVTGsQDEEDSK molecular association, regulation; intracellular localization TrkB(DISRUPTS) 37506696 7 85 48 regulates TRKB transport to the cell membrane -PKM PKM Carbohydrate Metabolism - glycolysis and gluconeogenesis; Carbohydrate Metabolism - pyruvate; EC 2.7.1.40; KINASE; Kinase, other; Mitochondrial; Nucleotide Metabolism - purine P14618 5315 15q23 human T405-gl 394791402 LRRLAPItSDPTEAT molecular association, regulation; intracellular localization; protein conformation; phosphorylation cell growth, induced ERK2(INDUCES); ERK1(INDUCES) 29229835 2 1 0 promotes Warburg effect and cell proliferation, tumor growth, disassociation of the PKM2 tetramer ; nuclear translocation -Srf SRF Motility/polarity/chemotaxis; Transcription factor Q9JM73 20807 17|17 C mouse S99-p 447692 RGLKRSLsEMELGVV transcription, induced 21109534 14 3 5 -APP APP Apoptosis; Cell surface; Membrane protein, integral; Receptor, misc.; Transcription factor P05067 351 21q21.3 human K699-ne 12124806 AEDVGSNkGAIIGLM Beta-APP transcription, inhibited Fe65(DISRUPTS) 18096514 1 0 0 -DYRK2 DYRK2 iso2 EC 2.7.12.1; KINASE; Kinase, protein; Protein kinase, CMGC; Protein kinase, dual-specificity (non-receptor) Q92630-2 8445 12q15 human S499-p 1874397822 KLPPPSSsASKLRTN enzymatic activity, induced cell cycle regulation; apoptosis, induced 34363019 1 1 0 -Crmp1 CRMP-1 Cell development/differentiation; Cytoskeletal; Hydrolase P97427 12933 5 B3|5 19.96 cM mouse S524-p 4712824 PSAKSSPsKHQPPPI phosphorylation 29758318 1 5 1 S522A KI mice -YAP1 YAP1 Oncoprotein; Transcription, coactivator/corepressor P46937 10413 11q22.1 human T77-p 126835301 NAVMNPKtANVPQTV molecular association, regulation apoptosis, induced; transcription, altered TEAD1(DISRUPTS); p73(INDUCES) 28171658 2 2 0 P73 transcription induced, TEAD1 inhibited -ARHGEF6 ARHGEF6 GEF; GEF, Rac/Rho; Motility/polarity/chemotaxis Q15052 9459 Xq26.3 human S225-p 456738 KSSERPLsPKAVKGF activity, induced cell motility, induced; cell growth, induced 25694429 1 25 0 GEF -GIT1 GIT1 GAP; GAP, ARF; Motility/polarity/chemotaxis Q9Y2X7 28964 17q11.2 human Y383-p 481671 DLDDQHDyDSVASDE intracellular localization cell motility, altered; cytoskeletal reorganization 20689073 4 12 180 important for podosome formation and PLC gamma activation -UNC5B UNC5B Membrane protein, integral; Receptor, misc. Q8IZJ1 219699 10q22.1 human T428-p 1870414700 FHPVNFKtARPSNPQ apoptosis, induced; transcription, inhibited 32929029 1 0 0 -PPP1R3A PPP1R3A Membrane protein, integral; Protein phosphatase, regulatory subunit Q16821 5506 7q31.1 human S65-p 449321 SSGTRRVsFADSFGF molecular association, regulation PPP1CA(DISRUPTS) 10748124 6 1 0 Association transiently lost after insulin treatment. -HOXA10 HOXA10 DNA-binding; Transcription factor P31260 3206 7p15.2 human T362-p 1880104200 FLFNMYLtRERRLEI protein stabilization transcription, induced; signaling pathway regulation 36216824 1 1 0 induces ITGB3 signaling pathway -Ulk1 ULK1 Autophagy; EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, Other; Protein kinase, Ser/Thr (non-receptor) O70405 22241 5|5 F mouse R170-me 1876620100 IADFGFArYLQSNMM Pkinase phosphorylation carcinogenesis, induced; autophagy, induced; cell growth, induced 35246531 1 1 0 induces autophosphorylation at T180 -TEK TIE2 EC 2.7.10.1; KINASE; Kinase, protein; Membrane protein, integral; Protein kinase, TK; Protein kinase, tyrosine (receptor) Q02763 7010 9p21.2 human Y1102-p 450256 MLEERKTyVNTTLYE molecular association, regulation; enzymatic activity, induced cell adhesion, altered SHC1(NOT_REPORTED) 14665640; 20973951 5 0 0 -AGO2 AGO2 EC 3.1.26.n2; RNA processing; RNA-binding Q9UKV8 27161 8q24.3 human Y393-p 17533102 ASFNTDPyVREFGIM ArgoL2 sumoylation; molecular association, regulation; protein conformation cell cycle regulation; carcinogenesis, induced; cell growth, inhibited; apoptosis, inhibited; RNA stability, altered KRas(DISRUPTS); NRas(DISRUPTS); DICER1(DISRUPTS); HRas(DISRUPTS); TRBP(DISRUPTS) 23636329; 25036361; 25175024; 31981897; 35923912 8 2 0 -USP35 USP35 DEUBIQUITINASE; EC 3.4.19.12; Protease; Ubiquitin conjugating system; Ubiquitin-specific protease Q9P2H5 57558 11q14.1 human S613-p 3214749 CRRRRLGsVMRPTED UCH intracellular localization carcinogenesis, induced; cell growth, induced; transcription, induced 34131114 1 10 0 -MELK MELK EC 2.7.10.2; EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, CAMK; Protein kinase, Ser/Thr (non-receptor); Protein kinase, tyrosine (non-receptor); RNA splicing Q14680 9833 9p13.2 human T478-p 451160 RNQCLKEtPIKIPVN molecular association, regulation translation, altered NIPP-1(INDUCES) 14699119 1 8 4 regulates translation = spliceosome assembly -MYC Myc DNA-binding; Nucleolus; Oncoprotein; Transcription factor P01106 4609 8q24.21 human K158-ac 458891 SGFSAAAkLVSEKLA Myc_N molecular association, regulation ZBTB17(INDUCES) 16126174 2 2 0 induces association with ZBTB17 on specific target promoters -Pard3 PAR3-alpha Adaptor/scaffold; Motility/polarity/chemotaxis Q9Z340 81918 19q12 rat S827-p 467266 REGFGRQsMSEKRTK molecular association, regulation cytoskeletal reorganization PKCZ(DISRUPTS) 12390250 7 11 0 cell polarity -Prkce PKCE EC 2.7.11.13; KINASE; Kinase, protein; Protein kinase, AGC; Protein kinase, Ser/Thr (non-receptor) P16054 18754 17|17 E4 mouse S350-p 486055 RSKSAPTsPCDQELK cell cycle regulation 18604201 2 10 0 -EGFR EGFR EC 2.7.10.1; KINASE; Kinase, protein; Membrane protein, integral; Oncoprotein; Protein kinase, TK; Protein kinase, tyrosine (receptor) P00533 1956 7p11.2 human K929-ub 1065302 EISSILEkGERLPQP PK_Tyr_Ser-Thr receptor recycling, inhibited; protein degradation 16543144; 17940017 2 4 0 -HAUS8 HAUS8 Cell cycle regulation Q9BT25 93323 19p13.11 human S129-p 20609206 TISKKPEsTSFSAPR intracellular localization cell cycle regulation; apoptosis, inhibited 21690413 1 0 0 localization to the spindle -ECT2 ECT2 GEF; GEF, Rac/Rho; Motility/polarity/chemotaxis Q9H8V3 1894 3q26.31 human T359-p 483847 YLYEKANtPELKKSV molecular association, regulation; intracellular localization carcinogenesis, altered; cell growth, altered 21189248 2 18 8 regulates association with PKCI-Par6 complex; activates Rac1 -RBM17 RBM17 RNA splicing; RNA-binding; Spliceosome Q96I25 84991 10p15.1 human T71-p 470694 DDRQIVDtPPHVAAG RNA splicing, induced; cell growth, inhibited; transcription, inhibited; cell adhesion, inhibited 22615491 1 24 5 upregulates EDA inclusion -Nos1 nNOS Amino Acid Metabolism - arginine and proline; EC 1.14.13.39; Oxidoreductase P29476 24598 12q16 rat K131-ac 2459108 QPLGPPTkAVDLSHQ activity, induced 18415985 1 1 0 -LCP2 SLP76 Adaptor/scaffold Q13094 3937 5q35.1 human Y128-p 448219 DGEDDGDyESPNEEE molecular association, regulation; phosphorylation cytoskeletal reorganization; transcription, induced; signaling pathway regulation NCK1(INDUCES); ITK(INDUCES); PIK3R1(INDUCES); VAV1(INDUCES) 11046020; 12817019; 15388330; 17148460; 21725281; 22534133; 22786724; 23901140; 33482200 25 1 0 transcriptional activity of NFAT and AP-1; regulates NK cell activation; regulates TCR signaling -Bad BAD Apoptosis Q61337 12015 19|19 A mouse S128-p 447861 EGMEEELsPFRGRSR Bcl-2_BAD molecular association, regulation apoptosis, induced 14-3-3 zeta(DISRUPTS) 12189144; 15901741 7 10 36 -Ntrk2 TrkB EC 2.7.10.1; KINASE; Kinase, protein; Membrane protein, integral; Protein kinase, TK; Protein kinase, tyrosine (receptor) Q63604 25054 17p14 rat Y705-p 448811 RDVYSTDyYRVGGHT PK_Tyr_Ser-Thr molecular association, regulation; enzymatic activity, induced translation, altered; transcription, altered; signaling pathway regulation PLCG1(INDUCES); SHC1(INDUCES); SH2D1A(INDUCES) 10533983; 16223723; 22563458; 9582017 15 0 49 -DYRK1B DYRK1B EC 2.7.12.1; KINASE; Kinase, protein; Protein kinase, CMGC; Protein kinase, dual-specificity (non-receptor) Q9Y463 9149 19q13.2 human Y273-p 449567 LGQRIYQyIQSRFYR Pkinase enzymatic activity, induced 10910078; 16257974 3 135 3521 -Nfkb1 NFkB-p105 DNA-binding; Transcription factor P25799 18033 3 G3|3 62.82 cM mouse S246-p 1170753400 DSKAPNAsNLKIVRM molecular association, regulation; protein conformation transcription, altered DNA(DISRUPTS) 29873020 1 1 0 -GRB14 GRB14 Adaptor/scaffold Q14449 2888 2q24.3 human S372-p 7611001 ISPMRSIsENSLVAM BPS molecular association, regulation cell cycle regulation; cell growth, altered INSR(INDUCES) 19359342 1 13 0 modulates the Grb14 inhibitory effect on insulin signaling -SYT6 SYT6 Membrane protein, integral; Vesicle Q5T7P8 148281 1p13.2 human T283-p 456501 DRKCKLQtRVHRKTL C2 activity, induced 16111671 1 0 0 -PLSCR1 PLSCR1 Calcium-binding; Membrane protein, integral O15162 5359 3q24 human T161-p 11380906 CGPSRPFtLRIIDNM Scramblase activity, induced 10770950 1 0 0 -ELAVL1 HuR RNA-binding Q15717 1994 19p13.2 human K313-ub 12357891 NGYRLGDkILQVSFK RRM_1 molecular association, regulation RNA stability, inhibited ETEA(INDUCES) RNA(DISRUPTS) 23618873 1 4 7 -Mecp2 MECP2 Transcription, coactivator/corepressor Q00566 29386 Xq37 rat S80-p 452713 AVPEASAsPKQRRSI activity, induced; molecular association, regulation; acetylation; protein conformation cell growth, inhibited; transcription, inhibited HDAC2(INDUCES); DGCR8(INDUCES) DNA(INDUCES) 24441681; 24636259 12 68 1 represses miR-134 processing, promotes upregulation of CREB level; amyloid suppressed NLGN1 expression, and decreased acetylation of histone -CBL CBL Adaptor/scaffold; EC 6.3.2.-; EC 6.3.2.19; Ligase; Motility/polarity/chemotaxis; Oncoprotein; UBIQUITIN LIGASE; Ubiquitin conjugating system; Ubiquitin ligase P22681 867 11q23.3 human T640-p 23090718 DVPRLGStFSLDTSM protein stabilization; phosphorylation; neddylation cell cycle regulation; DNA repair, induced; cell growth, inhibited; signaling pathway regulation 31315051 1 1 1 enhances TBRII neddylation, stabilization and signaling, induces SMAD2/3 phosphorylation -CNTROB LIP8 Cell cycle regulation Q8N137 116840 17p13.1 human T35-p 27565612 NQVSSEVtSQLYASL cell motility, inhibited 23291182 1 0 0 -Yap1 YAP1 Oncoprotein; Transcription, coactivator/corepressor P46938 22601 9|9 A1 mouse S274-p 3190663 PPPLAPQsPQGGVLG intracellular localization cell cycle regulation; cytoskeletal reorganization; signaling pathway regulation 33046882 4 24 1 Hippo pathway -WEE1 Wee1 EC 2.7.10.2; KINASE; Kinase, protein; Protein kinase, Other; Protein kinase, Ser/Thr (non-receptor); Protein kinase, tyrosine (non-receptor) P30291 7465 11p15.4 human S123-p 451132 EEGFGSSsPVKSPAA protein degradation; molecular association, regulation; phosphorylation cell cycle regulation BTRC(INDUCES); PLK1(INDUCES); FBW1B(INDUCES) 15070733; 16085715; 23051732 3 0 0 primes PLK1 phosphorylation -BTK Btk EC 2.7.10.2; KINASE; Kinase, protein; Protein kinase, TK; Protein kinase, tyrosine (non-receptor) Q06187 695 Xq22.1 human T495-p 28710301 EMRHRFQtQQLLEMC PK_Tyr_Ser-Thr protein degradation; molecular association, regulation; ubiquitination; intracellular localization; phosphorylation signaling pathway regulation 14-3-3 zeta(INDUCES) 23754751 1 0 0 induces tyrosine phosphorylation and BCR signaling -Mlxipl ChREBP Transcription factor Q8VIP2 171078 12q12 rat T666-p 458376 KMENRRItHISAEQK HLH intracellular localization transcription, altered 11698644 2 0 0 inhibits the DNA-binding activity of ChREBP -ERBB2 HER2 EC 2.7.10.1; KINASE; Kinase, protein; Membrane protein, integral; Oncoprotein; Protein kinase, TK; Protein kinase, tyrosine (receptor) P04626 2064 17q12 human T701-p 472481 TELVEPLtPSGAMPN molecular association, regulation; receptor internalization, inhibited; protein conformation EGFR(DISRUPTS) 28632938 4 10 27 Suppression of HER2 Thr701 phosphorylation by MEK inhibitors increases HER2/EGFR heterodimerization -Skp2 SKP2 Cell cycle regulation; UBIQUITIN LIGASE; Ubiquitin conjugating system; Ubiquitin ligase Q9Z0Z3 27401 15|15 A1 mouse K68-ac 25673101 HPQSPPRkRVKGKGS protein stabilization; intracellular localization carcinogenesis, induced; cell motility, induced 22770219 2 1 0 Skp2 cytoplasmic localization -CLIP1 Restin iso3 Cytoskeletal P30622-2 6249 12q24.31 human T1384-p 36744502 EMFGHWAtNCNDDET CLIP1_ZNF molecular association, regulation; intracellular localization DYNC1I1(INDUCES); dynactin 1(INDUCES) 25413345 1 1 0 interaction with dynein?dynactin complexes; regulates localization of p150 to microtubule plus ends, and transport of EGFR containing endosomes -TPH1 TPH1 Amino Acid Metabolism - tryptophan; EC 1.14.16.4; Oxidoreductase P17752 7166 11p15.1 human S58-p 451575 RKSKRRNsEFEIFVD molecular association, regulation 14-3-3 beta(INDUCES) 9334190 4 1 0 Interaction with 14-3-3 leads to increase in enzymatic activity of TPH1 and its stabilization. The interaction also inhibits dephosphorylation of TPH1. -GSK3B GSK3B EC 2.7.11.1; EC 2.7.11.26; KINASE; Kinase, protein; Protein kinase, CMGC; Protein kinase, Ser/Thr (non-receptor) P49841 2932 3q13.33 human K197-ub 573764864 DPDTAVLkLCDFGSA Pkinase activity, inhibited 30711629 0 2 0 -PAGE4 PAGE4 Cancer Testis Antigen (CTA) O60829 9506 Xp11.23 human T94-p 63280105 PNPKHAKtKEAGDGQ GAGE protein conformation 28289210 1 1 0 -SEC14L2 SEC14L2 Lipid-binding O76054 23541 22q12.2 human S289-p 455526 VQISRGSsHQVEYEI activity, induced 15680919 1 0 0 -Dlg1 DLG1 Adaptor/scaffold; Motility/polarity/chemotaxis Q62696 25252 11q22 rat T209-p 35547401 VNTDSLEtPTYVNGT MAGUK_N_PEST molecular association, regulation; intracellular localization cytoskeletal reorganization GKAP1(DISRUPTS) 15729360 1 1 0 -Cd247 CD3Z Membrane protein, integral; Receptor, misc. P24161 12503 1 H2.3|1 73.14 cM mouse Y142-p 448932 GKGHDGLyQGLSTAT ITAM carcinogenesis, inhibited; apoptosis, induced; signaling pathway regulation 31285342; 37000627 15 24 410 induces TCR signaling; TCR signaling -WDR62 WDR62 Adaptor/scaffold O43379 284403 19q13.12 human S49-p 3175148 LRRRTRLsTASEETV cell cycle regulation 25501809; 26713495 2 23 202 WDR62 regulation of the mitotic spindle; S49/T50 is critical for spindle alignment and mitotic integrity; microtubule association -NFAT5 NFAT5 Transcription factor O94916 10725 16q22.1 human K668-m3 1884021300 KQQQIQPkAYNPETL activity, induced; protein stabilization; molecular association, regulation; intracellular localization transcription, induced TRAF6(DISRUPTS); STAM1(INDUCES); KPNB1(INDUCES) 37429858 1 1 0 enhanced MGMT transcription; nuclear localizationn; positively correlated with p-EGFR Y1068 and p-EZH2 S21 expression; methylation protects NFAT5 from ubiquitin-mediated lysosome degradation -AR AR DNA-binding; Nuclear receptor; Transcription factor P10275 367 Xq12 human S426-p 449807 AAGPGSGsPSAAASS Androgen_recep transcription, altered 15684382 3 1 0 -CFTR CFTR Channel, chloride; EC 3.6.3.49; Hydrolase; Membrane protein, integral; Membrane protein, multi-pass; Transporter; Transporter, ABC family P13569 1080 7q31.2 human T604-p 2907506 NKTRILVtSKMEHLK activity, induced 12588899; 14695900 2 0 1 -Kcnn2 KCNN2 Channel, potassium; Membrane protein, integral; Membrane protein, multi-pass P70604 54262 18q11 rat S465-p 460687 QAIHQLRsVKMEQRK CaMBD activity, induced 30771223 2 0 0 Alleviates voltage-dependent inhibition of SK channels by Ca2+. -Stmn1 STMN1 Cytoskeletal P54227 16765 4 D3|4 66.76 cM mouse S63-p 448557 AAEERRKsHEAEVLK Stathmin protein stabilization carcinogenesis, induced; cell motility, induced; cell growth, induced 36484700 26 56 32 -Smpd3 SMPD3 EC 3.1.4.12; Lipid Metabolism - sphingolipid; Membrane protein, integral; Phospholipase Q9JJY3 58994 8|8 D3 mouse S173-p 17547983 QIKIYIDsPTNTSIS enzymatic activity, induced 22074919 1 2 0 -RAD9A RAD9A Apoptosis; Cell cycle regulation; DNA replication; Deoxyribonuclease; EC 3.1.11.2 Q99638 5883 11q13.2 human S277-p 449811 SHSQDLGsPERHQPV phosphorylation cell cycle regulation 12734188; 20305300 4 22 4 -Sik2 QIK EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, CAMK; Protein kinase, Ser/Thr (non-receptor) Q8CFH6 235344 9|9 A5.3 mouse S587-p 3212040 FREGRRAsDTSLTQG molecular association, regulation signaling pathway regulation 14-3-3 beta(INDUCES) 32457359 4 35 17 PKA-SIK signaling for the regulation of sleep need -CDT1 CDT1 DNA replication; DNA-binding; Motility/polarity/chemotaxis; Oncoprotein Q9H211 81620 16q24.3 human T29-p 455584 PPKLACRtPSPARPA molecular association, regulation cell cycle regulation; transcription, inhibited SKP2(INDUCES) 15855168; 21856198 3 11 1 Cdt1 protein is degraded in S phase even in T29A mutant (even though it no longer co-IPs with Skp2). Overexpression of WT Cdt1 induced rereplication (DNA content >4N) and this was even greater in the T29A mutant.; T29 phosphorylation impairs HBO1 binding at replication origins in response to stress, inhibiting transcription. -Dusp6 DUSP6 EC 3.1.3.16; EC 3.1.3.48; Motility/polarity/chemotaxis; PHOSPHATASE; Protein phosphatase, dual-specificity Q9DBB1 67603 10|10 D1 mouse S159-p 455265 DGSCSSSsPPLPVLG protein degradation signaling pathway regulation 22521266 4 0 0 represses expression of gluconeogenic genes and glucose output -ITGB4 ITGB4 Cell adhesion; Membrane protein, integral; Motility/polarity/chemotaxis; Receptor, misc. P16144 3691 17q25.1 human S1360-p 451654 VLRSPSGsQRPSVSD molecular association, regulation Plectin-1(DISRUPTS) 17615294 4 0 5 -MSH3 MSH3 DNA repair, damage P20585 4437 5q14.1 human K103-ac 14367131 PVKKKVKkVQQKEGG intracellular localization 32900932 1 1 0 -Sik3 QSK EC 2.7.11.1; KINASE; Kinase, protein; Motility/polarity/chemotaxis; Protein kinase, CAMK; Protein kinase, Ser/Thr (non-receptor) Q6P4S6 70661 9|9 A5.2 mouse S609-p 1868968411 QRYLANRsKRHTLAM molecular association, regulation signaling pathway regulation 14-3-3 beta(INDUCES) 32457359 1 0 0 PKA-SIK signaling for the regulation of sleep need -ACTR2 ARP2 Actin-binding; Cytoskeletal; Motility/polarity/chemotaxis P61160 10097 2p14 human T238-p 36440501 QKLALETtVLVESYT Actin intracellular localization carcinogenesis, induced; cell motility, induced; cytoskeletal reorganization 25601402; 27872092; 33755220 4 0 0 -GRK2 GRK2 EC 2.7.11.15; KINASE; Kinase, protein; Protein kinase, AGC; Protein kinase, Ser/Thr (non-receptor) P25098 156 11q13.2 human Y13-p 456872 AVLADVSyLMAMEKS protein degradation; molecular association, regulation G-alpha(q)(INDUCES) 11566877; 16725308 5 0 0 -Dpysl2 CRMP-2 Microtubule-binding; Motility/polarity/chemotaxis P47942 25416 15p12 rat S522-p 448082 PASSAKTsPAKQQAP sumoylation; molecular association, regulation; intracellular localization endocytosis, induced; cell growth, altered ROCK2(DISRUPTS) 15483118; 24036111; 27940916 31 49 84 -AURKA AurA EC 2.7.11.1; KINASE; Kinase, protein; Oncoprotein; Protein kinase, Other; Protein kinase, Ser/Thr (non-receptor) O14965 6790 20q13.2 human T287-p 457654 HAPSSRRtTLCGTLD Pkinase enzymatic activity, inhibited; enzymatic activity, induced 15173575; 23924325 5 6 2 -TAOK1 TAO1 EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, STE; Protein kinase, Ser/Thr (non-receptor) Q7L7X3 57551 17q11.2 human T443-p 1880716204 EHFATIRtASLVTRQ molecular association, regulation Other(INDUCES) 36595571 1 1 0 induces binding to membrane phosphoinositides -HSPA1A HSP70 Chaperone; Heat shock protein; Motility/polarity/chemotaxis P0DMV8 3303 6p21.33 human R416-me 1877047301 VMTALIKrNSTIPTK HSP70 protein stabilization carcinogenesis, induced; cell growth, induced; apoptosis, inhibited RNA(INDUCES) 32699135 1 1 0 binding and stabilization of BCL2 mRNA -RNF187 RNF187 EC 6.3.2.-; EC 6.3.2.19; UBIQUITIN LIGASE; Ubiquitin conjugating system; Ubiquitin ligase Q5TA31 149603 1q42.13 human R109-me 347475301 GPLCAACrMAAGPEP protein stabilization; molecular association, regulation; protein conformation transcription, induced Jun(INDUCES) 23624934 1 1 0 dimerisation, expression of Jun target genes -STK39 STLK3 EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, STE; Protein kinase, Ser/Thr (non-receptor) Q9UEW8 27347 2q24.3 human T354-p 483899 IEKLLTRtPDIAQRA signaling pathway regulation 21733846 0 18 6 -Stat3 STAT3 DNA-binding; Motility/polarity/chemotaxis; Nuclear receptor co-regulator; Transcription factor P42227 20848 11 D|11 63.82 cM mouse K707-ac 475839 GSAAPYLkTKFICVT acetylation; phosphorylation transcription, inhibited SIRT1(INDUCES) 19295512 1 1 0 SIRT1 downregulates phosphorylation at STAT3-Y705 and transactivation, deacetylation of STAT3 -PPP1CC PPP1CC EC 3.1.3.16; Motility/polarity/chemotaxis; Nucleolus; PHOSPHATASE; Protein phosphatase, Ser/Thr (non-receptor) P36873 5501 12q24.11 human T307-p 3190033 EKKKPNAtRPVTPPR enzymatic activity, inhibited 10880350 1 4 4 in vitro -DDX5 DDX5 EC 3.6.4.13; Helicase; Nuclear receptor co-regulator; Nucleolus; RNA splicing; RNA-binding; Spliceosome P17844 1655 17q23.3 human R502-m2 476729 DRYSAGKrGGFNTFR P68HR molecular association, regulation XRN2(INDUCES) 31267554 1 5 9 represses R-loops -H3-3A H3F3A DNA-binding P84243 3020 1q42.12 human K79-m1 18545328 REIAQDFkTDLRFQS Histone molecular association, regulation L3MBTL iso4(INDUCES) 23583077 0 5 15 -ITCH ITCH iso2 EC 6.3.2.-; EC 6.3.2.19; Ligase; UBIQUITIN LIGASE; Ubiquitin conjugating system; Ubiquitin ligase Q96J02-2 83737 20q11.22 human S161-p 33522000 TTCSESAsQNDDGSR molecular association, regulation; enzymatic activity, induced HECTD1(DISRUPTS) 23435430 1 0 0 ubiquitination and degradation of c-FLIP and c-JUN -SLC12A2 NKCC1 Membrane protein, integral; Membrane protein, multi-pass; Transporter; Transporter, SLC family P55011 6558 5q23.3 human T230-p 459123 RIDHYRHtAAQLGEK AA_permease_N activity, induced 12145304 3 7 3 -PRPS1 PRPS1 Carbohydrate Metabolism - pentose phosphate pathway; EC 2.7.6.1; Kinase, other; Nucleotide Metabolism - purine P60891 5631 Xq22.3 human T228-p 34551795 DMADTCGtICHAADK Pribosyl_synth molecular association, regulation; enzymatic activity, induced DNA repair, induced; cell growth, induced Other(NOT_REPORTED) 34343500 1 1 1 inhibits ADP binding -UBR5 UBR5 EC 6.3.2.-; EC 6.3.2.19; Ligase; Nuclear receptor co-regulator; UBIQUITIN LIGASE; Ubiquitin conjugating system; Ubiquitin ligase O95071 51366 8q22.3 human S2483-p 480595 ENRKRHGsSRSVVDM translation, inhibited 28559278 1 9 9 translational repression of TRAF3 mRNA -Krt8 K8 Cytoskeletal Q10758 25626 7q36 rat S432-p 448540 SSYGGLTsPGFSYGM cytoskeletal reorganization 18708634 27 8 23 -DLG4 PSD-95 Adaptor/scaffold P78352 1742 17p13.1 human S25-p 3609100 DTPPLEHsPAHLPNQ protein stabilization; molecular association, regulation; protein conformation; palmitoylation neural plasticity PIN1(INDUCES) 32231520; 32256312 4 0 0 -METTL3 METTL3 EC 2.1.1.62; METHYLTRANSFERASE; Methyltransferase; RNA processing Q86U44 56339 14q11.2 human S43-p 483736 RNPEAALsPTFRSDS protein stabilization; molecular association, regulation; methylation carcinogenesis, induced; DNA repair, induced; cell differentiation, induced POLR2A(INDUCES); USP5(DISRUPTS) 32615088; 33217317 2 28 0 -OPN3 encephalopsin GPCR, family 1; Membrane protein, integral; Membrane protein, multi-pass; Receptor, GPCR Q9H1Y3 23596 1q43 human S380-p 25303237 FIITSDEsLSVDDSD carcinogenesis, induced 35180853 1 0 1 -PXN PXN iso2 Adaptor/scaffold; Cell adhesion; Cytoskeletal; Motility/polarity/chemotaxis P49023-2 5829 12q24.23 human S130-p 450228 KQKSAEPsPTVMSTS Paxillin cell cycle regulation; carcinogenesis, altered; transcription, altered 20628053 5 25 4 regulates Erk1/2-induced cell proliferation and transcription -Cd247 CD3Z Membrane protein, integral; Receptor, misc. P24161 12503 1 H2.3|1 73.14 cM mouse K54-ub 18381100 TALYLRAkFSRSAET TCR_zetazeta molecular association, regulation signaling pathway regulation ZAP70(DISRUPTS) 20637659 1 1 0 -EP300 p300 ACETYLTRANSFERASE; Acetyltransferase; EC 2.3.1.48; Motility/polarity/chemotaxis; Nuclear receptor co-regulator; Transcription, coactivator/corepressor Q09472 2033 22q13.2 human S2315-p 486263 RSPQPVPsPRPQSQP molecular association, regulation; enzymatic activity, induced transcription, altered SP1(NOT_REPORTED) 17623675 2 10 1 controls EGF-induced keratin 16 promoter activity ; regulates HAT activity of p300 -RAF1 RAF1 EC 2.7.11.1; KINASE; Kinase, protein; Oncoprotein; Protein kinase, Ser/Thr (non-receptor); Protein kinase, TKL P04049 5894 3p25.2 human S339-p 447743 PRGQRDSsYYWEIEA molecular association, regulation; intracellular localization; enzymatic activity, induced Bcl-2(INDUCES); MEK1(INDUCES) 10998357; 11274179; 12244094; 15849194; 9234708 9 1 1 -Prkaca PKACA EC 2.7.11.11; KINASE; Kinase, protein; Protein kinase, AGC; Protein kinase, Ser/Thr (non-receptor) P05132 18747 8|8 C2 mouse T198-p 448459 RVKGRTWtLCGTPEY Pkinase protein stabilization; protein conformation; enzymatic activity, induced; phosphorylation transcription, induced; signaling pathway regulation 15618230; 19965870; 22334660; 30753874; 36995368; 8395513; 9488457 34 48 277 -H3C1 H3 DNA-binding P68431 8350 6p22.2 human Y41-p 10897613 GVKKPHRyRPGTVAL Histone molecular association, regulation chromatin organization, altered; apoptosis, inhibited; transcription, induced; transcription, altered SMARCA4(INDUCES); HP1 alpha(DISRUPTS) 19783980; 21156283; 25553095; 27275536; 27799566; 32232334 7 3 4 -DAPK1 DAPK1 Apoptosis; Autophagy; EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, CAMK; Protein kinase, Ser/Thr (non-receptor) P53355 1612 9q21.33 human S308-p 448142 ARKKWKQsVRLISLC protein degradation; molecular association, regulation; enzymatic activity, inhibited; phosphorylation apoptosis, altered; cytoskeletal reorganization; cell adhesion, altered; cell growth, altered CHIP(DISRUPTS); NMDAR2B(DISRUPTS); MIB1(DISRUPTS); CAMK2A(INDUCES); Calmodulin(DISRUPTS) 11579085; 17324930; 20220139; 28614711; 32977471 11 4 0 inhibits phosphorylation of TPM3 -CAV1 caveolin-1 Adaptor/scaffold; Motility/polarity/chemotaxis; Nuclear receptor co-regulator Q03135 857 7q31.2 human Y14-p 448422 VDSEGHLyTVPIREQ activity, induced; molecular association, regulation; intracellular localization; enzymatic activity, altered; phosphorylation cell cycle regulation; carcinogenesis, induced; cell motility, induced; apoptosis, induced; cell adhesion, induced; cell adhesion, inhibited; signaling pathway regulation; cell growth, induced; cell motility, altered; cell growth, altered; endocytosis, inhibited; transcription, altered; endocytosis, induced; cell adhesion, altered; cytoskeletal reorganization; autophagy, inhibited CSK(INDUCES); GRB7(INDUCES); SHP-2(INDUCES); CDC42(INDUCES); MMP9(INDUCES); MFN2(INDUCES); RCV1(DISRUPTS); CTNNB1(INDUCES); DRP1(INDUCES); TRAF2(INDUCES) 11075810; 11805080; 12135605; 12925753; 15466865; 15692085; 16332692; 17190831; 18347068; 18922892; 20228056; 21705803; 24427291; 24632723; 29371975; 33928090; 34321069; 35413643; 35954304; 36421712 55 45 830 -HLA-DRB1 HLA-DRB1 Membrane protein, integral P01911 3123 6p21.32 human K254-ub 6140802 FIYFRNQkGHSGLQP intracellular localization 19117940 1 0 1 -STK24 MST3 EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, STE; Protein kinase, Ser/Thr (non-receptor) Q9Y6E0 8428 13q32.2 human T190-p 468211 DTQIKRNtFVGTPFW Pkinase enzymatic activity, induced cell motility, altered 17046825; 35413286 5 34 138 -RBBP5 RBBP5 Transcription, coactivator/corepressor Q15291 5929 1q32.1 human S350-p 6747300 VEYEEREsEFDIEDE molecular association, regulation ASH2L(INDUCES) 25593305 1 13 0 increases the catalytic activity of MLL3 -Ptpn2 PTPN2 EC 3.1.3.48; Motility/polarity/chemotaxis; PHOSPHATASE; Protein phosphatase, tyrosine (non-receptor) Q06180 19255 18|18 E1 mouse S298-p 3181136 ELSKEDLsPICDHSQ phosphorylation; enzymatic activity, induced carcinogenesis, induced; apoptosis, inhibited 37000627 1 29 17 dephosphorylates CD3Z -Tp53 p53 Activator; DNA-binding; Motility/polarity/chemotaxis; Nuclear receptor co-regulator; Transcription factor; Tumor suppressor P02340 22059 11 B3|11 42.83 cM mouse K370-ub 464659 SSYLKTKkGQSTSRH transcription, altered 15964796 9 0 0 p53K6R (K378/383/369/379/367/370/R) mutant is still ubiquitinated and shows normal stability of p53 before and after DNA damage -RBM4 RBM4 Nuclear receptor co-regulator; Nucleolus; RNA splicing; RNA-binding Q9BWF3 5936 11q13.2 human S309-p 476783 SYYGRDRsPLRRATA molecular association, regulation; intracellular localization translation, induced AGO2(DISRUPTS); EIF4A1(INDUCES) 17284590; 23897118 2 11 1 -Bdkrb2 BKR2 GPCR, family 1; Membrane protein, integral; Membrane protein, multi-pass; Receptor, GPCR P25023 25245 6q32 rat T167-p 457435 RYLALVKtMSMGRMR 7tm_1 receptor desensitization, altered; receptor internalization, altered; activity, inhibited 11807751; 9837936 2 0 0 -Casp9 CASP9 Apoptosis; EC 3.4.22.62; Protease Q8C3Q9 12371 4|4 E1 mouse T163-p 449563 PEVLRPEtPRPVDIG enzymatic activity, inhibited apoptosis, altered 19081073 7 4 10 -Sh3bp2 SH3BP2 Adaptor/scaffold Q06649 24055 5|5 B2 mouse Y183-p 449092 HEDEDDSyLEPDSPG molecular association, regulation PLCG2(INDUCES); VAV1(INDUCES) 19833725 4 0 0 positively regulates 3BP2-mediated transcriptional activation of NFAT -CBX4 CBX4 EC 6.3.2.-; SUMO LIGASE; SUMO conjugating system; SUMO ligase; Transcription, coactivator/corepressor O00257 8535 17q25.3 human K178-ub 573756664 LQYQGGHkEAPSPTC protein degradation 32111827 1 1 0 -Plekhf1 PKHF1 Q3TB82 72287 7|7 B3 mouse Y208-p 1868624702 LRVCSLCyRELAAQK FYVE molecular association, regulation endocytosis, induced; signaling pathway regulation caveolin-1(INDUCES) 31189603 1 0 0 endocytosis of bacteria -Nfatc2 NFAT1 DNA-binding; Transcription factor Q60591 18019 2 H3|2 88.91 cM mouse S54-p 455326 IAHKAISsPSGLAYP transcription, induced 11030334 0 1 0 -TLK1 TLK1 EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, Other; Protein kinase, Ser/Thr (non-receptor) Q9UKI8 9874 2q31.1 human S743-p 449050 PHMRRSNsSGNLHMA enzymatic activity, inhibited 12660173 3 0 0 -ACD ACD Adaptor/scaffold Q96AP0 65057 16q22.1 human K147-ub 25218502 QDLDVQKkLYDCLEE protein stabilization; molecular association, regulation; intracellular localization DNA repair, altered POT1(INDUCES) 22101936 1 0 0 induces telomere shortening and chromosome fusions via alternative NHEJ pathway -PNKP Pnk1 DNA-binding; EC 2.7.1.78; EC 3.1.3.32; Kinase, other; Phosphatase (non-protein) Q96T60 11284 19q13.33 human S126-p 460833 PPGTPLVsQDEKRDA molecular association, regulation; enzymatic activity, inhibited; intracellular localization; enzymatic activity, induced DNA repair, induced DNA(INDUCES) 21637298; 21824916 2 4 19 -KCNK1 KCNK1 Membrane protein, integral; Membrane protein, multi-pass O00180 3775 1q42.2 human K274-sm 3142603 FCELHELkKFRKMFY activity, inhibited 15820677; 20498050 3 1 0 -FGFR1 FGFR1 EC 2.7.10.1; KINASE; Kinase, protein; Membrane protein, integral; Oncoprotein; Protein kinase, TK; Protein kinase, tyrosine (receptor) P11362 2260 8p11.23 human Y654-p 447919 DIHHIDYyKKTTNGR PK_Tyr_Ser-Thr phosphorylation; enzymatic activity, induced cell differentiation, altered; cell motility, altered; cell growth, altered 16507368; 8622701 17 18 172 Double Y->F mutant has less neurite outgrowth in PC12 cells (differentiation), and less cell proliferation in L-6 cells.; Data collected by isolating phosphorylated species in vitro and confirming their phosphorylation states by mass spec. Y->F mutations were also done but unpublished. -Myb Myb DNA-binding; Oncoprotein; Transcription factor P06876 17863 10 A3|10 9.75 cM mouse T354-p 1308924 CLGEHHAtPSLPADP protein degradation 18006338 1 0 0 stress-induced degredation -RAD17 RAD17 Cell cycle regulation O75943 5884 5q13.2 human Y676-p 1868913301 ENIIIEDyESDGT__ molecular association, regulation; phosphorylation RAD1(INDUCES) 31353086 1 0 0 induces phosphorylation of other sites -APP APP Apoptosis; Cell surface; Membrane protein, integral; Receptor, misc.; Transcription factor P05067 351 21q21.3 human K726-ne 12124804 TLVMLKKkQYTSIHH APP_amyloid transcription, inhibited Fe65(DISRUPTS) 18096514 1 0 0 -PTTG1 Securin Cell cycle regulation; Oncoprotein O95997 9232 5q33.3 human S165-p 452603 LFQLGPPsPVKMPSP Securin protein stabilization; molecular association, regulation; phosphorylation carcinogenesis, altered; transcription, induced; signaling pathway regulation CTNNB1(INDUCES) 37400529 2 50 2 induces GSK3B dephosphorylation, regulates Wnt/?-catenin signaling -Arrb2 ARRB2 Adaptor/scaffold Q91YI4 216869 11 B3|11 42.99 cM mouse K296-ub 6140809 LALDGQLkHEDTNLA Arrestin_C molecular association, regulation mAChR M2(INDUCES); mAChR m1(INDUCES) 19055777 1 1 0 -PTK6 Brk EC 2.7.10.2; KINASE; Kinase, protein; Protein kinase, TK; Protein kinase, tyrosine (non-receptor) Q13882 5753 20q13.33 human Y447-p 450276 RLSSFTSyENPT___ molecular association, regulation; enzymatic activity, inhibited Akt1(DISRUPTS) 12121988; 14676834; 15539407 6 16 367 -Wnk4 WNK4 EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, Other; Protein kinase, Ser/Thr (non-receptor) Q80UE6 69847 11|11 D mouse S64-p 15504094 SRPSRRSsVDLGLLS enzymatic activity, induced 28096417 1 1 1 -Syk Syk EC 2.7.10.2; KINASE; Kinase, protein; Protein kinase, TK; Protein kinase, tyrosine (non-receptor) Q64725 25155 17p14 rat Y624-p 459326 ELRLRNYyYDVVN__ molecular association, regulation; phosphorylation; enzymatic activity, induced FCER1G(INDUCES) 20554527 3 2 5 mutation of this site stimulates phosphorylation of Y317, Y519 and Y520; required for activation of ERK1/2 and p38MAP kinases; required for activation of NFAT and NFkB -SMAD4 SMAD4 DNA-binding; Nuclear receptor co-regulator; Transcription, coactivator/corepressor Q13485 4089 18q21.2 human K113-sm 2793926 KNELKHVkYCQYAFD MH1 protein stabilization; intracellular localization transcription, induced; transcription, inhibited; signaling pathway regulation 12621041; 12740389; 14750902; 15028714 5 1 0 -STING1 STING Apoptosis; Endoplasmic reticulum; Membrane protein, integral; Membrane protein, multi-pass; Mitochondrial Q86WV6 340061 5q31.2 human K347-ub 1883300101 EVTVGSLkTSAVPST protein degradation 35871231 1 0 0 UFL1 reduces STING ubiquitination -Smad7 SMAD7 DNA-binding; Transcription factor O35253 17131 18|18 E3 mouse K70-ac 458990 GKAVRGAkGHHHPHP protein stabilization; ubiquitination apoptosis, induced 12408818; 17098745 2 1 0 inhibits ubiquitination further inducing protein stabilization; inhibits ubiquitination -APEX1 APE1 DNA repair, damage; DNA-binding; Deoxyribonuclease; EC 4.2.99.18; Endoplasmic reticulum; Hydrolase; Lyase; Nuclear receptor co-regulator; Nucleolus; Transcription, coactivator/corepressor P27695 328 14q11.2 human K7-ac 459076 _MPKRGKkGAVAEDG molecular association, regulation; enzymatic activity, inhibited; enzymatic activity, induced DNA repair, induced; cell growth, induced; DNA repair, inhibited; transcription, inhibited XRCC1(INDUCES); XRCC1(DISRUPTS) DNA(INDUCES) 14633989; 19934257; 27655688; 27994014 5 2 0 -PTPN12 PTP-PEST EC 3.1.3.48; Motility/polarity/chemotaxis; PHOSPHATASE; Protein phosphatase, tyrosine (non-receptor) Q05209 5782 7q11.23 human S19-p 18014400 QRVQAMKsPDHNGED enzymatic activity, inhibited cell motility, induced 28842430 2 11 2 selectively decreased its activity toward the human epidermal growth factor receptor (HER)-2 pY(1196) site -Mapk8 JNK1 EC 2.7.11.24; KINASE; Kinase, protein; Protein kinase, CMGC; Protein kinase, Ser/Thr (non-receptor) Q91Y86 26419 14|14 B mouse T183-p 447643 AGTSFMMtPYVVTRY Pkinase protein degradation; acetylation; molecular association, regulation; enzymatic activity, induced cell cycle regulation; carcinogenesis, induced; carcinogenesis, inhibited; cell growth, inhibited; apoptosis, induced; cell motility, induced; cell motility, inhibited; transcription, induced; signaling pathway regulation; transcription, altered; cell growth, induced; apoptosis, inhibited; transcription, inhibited p300(INDUCES); GSK3B(INDUCES); CTNNB1(INDUCES); PCAF(INDUCES) 18032450; 18952597; 21887248; 26306048; 34914791; 34962918; 35370650; 35637461; 36070687; 36310322 275 33 392 -AFAP1 AFAP Adaptor/scaffold Q8N556 60312 4p16.1 human Y453-p 3891002 PEALHYDyIDVEMSA molecular association, regulation Src(INDUCES) 9655255 1 0 0 Src Y529F Src mutant -USP31 USP31 DEUBIQUITINASE; EC 3.4.19.12; Protease; Ubiquitin-specific protease Q70CQ4 57478 16p12.2 human K1264-ac 1881321504 SSVKSVCkNTGDDEA enzymatic activity, inhibited carcinogenesis, induced; apoptosis, inhibited 34184746 1 1 0 acetylation of USP31 is beneficial for cancer cell growth -Gab2 GAB2 Adaptor/scaffold Q9Z1S8 14389 7|7 E1 mouse S160-p 448382 LLRERKSsAPSHSSQ molecular association, regulation; phosphorylation cell motility, inhibited; signaling pathway regulation SHP-2(DISRUPTS) 23401857 3 1 0 inhibits ERK1/2 phosphorylation, modulates Ras/MAPK signaling pathway -MAP2 MAP2 Cytoskeletal; Motility/polarity/chemotaxis P11137 4133 2q34 human S1710-p 456809 HVTSKCGsLKNIRHR Tubulin-binding molecular association, regulation; intracellular localization cytoskeletal reorganization TUBA1A(INDUCES); ACTB(INDUCES) 11029056 2 1 0 -NFATC3 NFAT4 DNA-binding; Transcription factor Q12968 4775 16q22.1 human S211-p 11507600 TLGSPLTsPGGSPGG intracellular localization 9630228 1 1 1 cytoplasmic localization (inhibition of nuclear localization) -NADK NADK Cofactor and Vitamin Metabolism - nicotinate and nicotinamide; EC 2.7.1.23; Kinase, other O95544 65220 1p36.33 human S64-p 467326 KEFRRTRsLHGPCPV enzymatic activity, induced carcinogenesis, induced 34133937 1 33 11 -CTNND1 CTNND1 iso3 Actin-binding; Adaptor/scaffold; Cell adhesion; G protein regulator, misc.; Motility/polarity/chemotaxis O60716-3 1500 11q12.1 human S269-p 470326 QVRVGGSsVDLHRFH molecular association, regulation signaling pathway regulation Kaiso(INDUCES); CDH1(DISRUPTS) 21670201 2 54 8 prevents Kaiso binding to Tcf-4 and B-catenin, induces Kaiso binding to CDKN2A promoter, inhibiting CDKN2A gene expression -PHF8 PHF8 DEMETHYLASE; Demethylase; EC 1.14.11.27; Nucleolus Q9UPP1 23133 Xp11.22 human S120-p 453946 GKPVKTGsPTFVREL cell growth, inhibited; cell differentiation, induced; transcription, induced 23518351 2 16 0 -SORBS2 ArgBP2 iso2 Adaptor/scaffold; Motility/polarity/chemotaxis O94875-2 8470 4q35.1 human Y175-p 7783536 YTYNAGLyNPPYSAQ protein conformation 24475245 1 0 1 reduced self-interaction -IDH2 IDH2 Carbohydrate Metabolism - citrate (TCA) cycle; EC 1.1.1.42; Mitochondrial; Other Amino Acids Metabolism - glutathione; Oxidoreductase P48735 3418 15q26.1 human Y107-p 1914598 SALATQKySVAVKCA Iso_dh intracellular localization 34289383 1 0 6 enhances ACAT1 recruitment -ECT2 ECT2 GEF; GEF, Rac/Rho; Motility/polarity/chemotaxis Q9H8V3 1894 3q26.31 human T846-p 457521 RAFSFSKtPKRALRR intracellular localization cell cycle regulation 22172673 2 5 4 -POU5F1 Oct4 DNA-binding; Transcription factor Q01860 5460 6p21.33 human K123-sm 486291 TVTPGAVkLEKEKLE protein degradation; protein stabilization; molecular association, regulation cell differentiation, inhibited; carcinogenesis, induced; transcription, induced DNA(INDUCES) 17525163; 23002208 4 0 0 -ABL2 Arg EC 2.7.10.2; KINASE; Kinase, protein; Oncoprotein; Protein kinase, TK; Protein kinase, tyrosine (non-receptor) P42684 27 1q25.2 human Y261-p 455657 GLVTTLHyPAPKCNK protein stabilization; ubiquitination 15735735 1 0 0 -BCR Bcr EC 2.7.11.1; GAP; GAP, Rac/Rho; GEF, Rac/Rho; KINASE; Kinase, protein; Oncoprotein; Protein kinase, Ser/Thr (non-receptor); Protein kinase, atypical P11274 613 22q11.23 human Y360-p 447796 VSPSPTTyRMFRDKS phosphorylation; enzymatic activity, induced 8622703; 9467953 4 1 29 -GPHN gephyrin Adaptor/scaffold; EC 2.10.1.1; EC 2.7.7.75 Q9NQX3 10243 14q23.3-q24.1 human S270-p 2020113 LSTTPSEsPRAQATS intracellular localization cytoskeletal reorganization 33796945 10 23 2 -THEM4 CTMP EC 3.1.2.2; Mitochondrial Q5T1C6 117145 1q21.3 human S38-p 9721502 PELRSFSsEEVILKD intracellular localization 19604401 1 1 0 -Kcnma1 KCNMA1 iso5 Channel, potassium; Endoplasmic reticulum; Membrane protein, integral; Membrane protein, multi-pass Q08460-5 16531 14|14 A3 mouse S1112-p 466425 QSSSKKSsSVHSIPS activity, induced 23407708 2 0 0 regulates NO/cGMP signaling -FKBP5 FKBP5 Chaperone; EC 5.2.1.8; Isomerase Q13451 2289 6p21.31 human K155-ac 63115302 IIRRTKRkGEGYSNP molecular association, regulation carcinogenesis, altered; apoptosis, induced PHLPP(DISRUPTS); Akt1(DISRUPTS) 28147277 1 1 0 induces Akt phosphorylation at S473 and enzymatic activation, regulates cancer cell sensitivity to genotoxic agents -Rims1 RIMS1 Adaptor/scaffold; Vesicle Q99NE5 116837 1|1 A5 mouse S413-p 4725270 TWHSRETsPISSHPV molecular association, regulation neural plasticity 14-3-3 eta(INDUCES) 15543142 1 3 0 Long-term potentiation -HNRNPU hnRNP U DNA-binding; Nuclear receptor co-regulator; RNA splicing; RNA-binding; Spliceosome Q00839 3192 1q44 human S14-p 18010531 NVKKLKVsELKEELK SAP molecular association, regulation; intracellular localization cell cycle regulation; chromatin organization, altered DNA(DISRUPTS) 33053167 1 5 0 -Nefl NFL Cytoskeletal P08551 18039 14|14 D1 mouse S63-p 2020617 SYSSSSGsLMPSLEN Filament_head molecular association, regulation; intracellular localization 14-3-3 gamma(INDUCES) 23230147 2 0 0 regulates NF-L dynamic exchange rate and neurofilament disassembly -UFD1 UFD1L DEUBIQUITINASE; Ubiquitin conjugating system; Ubiquitin-specific protease Q92890 7353 22q11.21 human S229-p 15428799 ELGFRAFsGSGNRLD protein stabilization; molecular association, regulation VCP(DISRUPTS) 31477623 1 7 1 phosphorylation of this site inhibits ER-associated degradation (ERAD) -Cacna1c CACNA1C Channel, calcium; Membrane protein, integral; Membrane protein, multi-pass Q01815 12288 6 F1|6 55.86 cM mouse S783-p 457631 KKLARTAsPEKKQEV activity, inhibited STX1A(DISRUPTS); SNAP-25(DISRUPTS) 16155576 1 0 0 -GBP1 GBP1 Cell adhesion; Hydrolase; Vesicle P32455 2633 1p22.2 human K51-ub 1879987800 VGLYRTGkSYLMNKL apoptosis, induced 31268602 1 0 0 required for IFN-gamma-enhanced cell death upon Toxoplasma infection -Pparg PPAR-gamma iso2 DNA-binding; Nuclear receptor; Transcription factor P37238-2 19016 6 E3|6 53.41 cM mouse S21-p 12170301 GISSVDLsVMEDHSH PPARgamma_N intracellular localization transcription, altered 20026644 1 0 0 -Ncf1 p47phox EC 1.-.-.-; Oxidoreductase Q09014 17969 5 G2|5 74.47 cM mouse S208-p 465580 KRGWVPAsYLEPLDS molecular association, regulation; phosphorylation CYBA(DISRUPTS) 33910977 2 0 0 inhibits AKT phosphorylation -PIP5K1C PIP5K1C Carbohydrate Metabolism - inositol phosphate; EC 2.7.1.68; Kinase, lipid; Motility/polarity/chemotaxis O60331 23396 19p13.3 human K97-ub 486880 TVGHLSSkPERDVLM protein degradation; molecular association, regulation carcinogenesis, induced; cell motility, induced; cell adhesion, induced; cytoskeletal reorganization talin 1(DISRUPTS) 23572508 1 8 97 invasion and metastasis -GFAP GFAP Cytoskeletal P14136 2670 17q21.31 human T7-p 449617 _MERRRItSAARRSY Filament_head protein stabilization 12177195 6 0 0 -AKT2 Akt2 EC 2.7.11.1; KINASE; Kinase, protein; Oncoprotein; Protein kinase, AGC; Protein kinase, Ser/Thr (non-receptor) P31751 208 19q13.2 human T309-p 448537 SDGATMKtFCGTPEY Pkinase intracellular localization; enzymatic activity, induced 9374542 16 5 23 -PHGDH PHGDH Amino Acid Metabolism - glycine, serine and threonine; Cell development/differentiation; EC 1.1.1.95; Oxidoreductase O43175 26227 1p12 human K330-ub 15394648 SAFSPHTkPWIGLAE PGDH_inter protein degradation carcinogenesis, inhibited; cell growth, inhibited 32478681; 35788583 2 1 1 -Kcnd3 Kv4.3 Channel, potassium; Membrane protein, integral; Membrane protein, multi-pass Q62897 65195 2q34 rat S569-p 455338 LPATRLRsMQELSTI activity, inhibited 18599872 2 1 2 -FOSL1 FRA1 DNA-binding; Transcription factor P15407 8061 11q13.1 human T227-p 50205700 LMTTPSLtPFTPSLV cell motility, induced; transcription, induced 27816489 2 0 0 -DDIT4 DDIT4 Q9NX09 54541 10q22.1 human K129-ub 4106211 QLVSQVGkELLRLAY RTP801_C molecular association, regulation HSC70(INDUCES) 36170669 1 11 60 -TP53 p53 Activator; DNA-binding; Motility/polarity/chemotaxis; Nuclear receptor co-regulator; Transcription factor; Tumor suppressor P04637 7157 17p13.1 human K372-ub 464660 HSSHLKSkKGQSTSR protein degradation; molecular association, regulation; intracellular localization transcription, inhibited ING1(DISRUPTS) 11046142; 17371868; 19927155; 21731648 9 0 0 K370/372/373/381/382/386/R mutant shows 613-fold activation of p53; binds unmodified or six multimonoubiquitinated forms of wild-type p53 -NUP98 NUP98 iso2 Motility/polarity/chemotaxis; Nucleoporin P52948-2 4928 11p15.4 human T529-p 3149520 AAQKALTtPTHYKLT intracellular localization 21335236 1 13 9 as multiple sites (13PM) mutant -Camk2b CAMK2B EC 2.7.11.17; KINASE; Kinase, protein; Protein kinase, CAMK; Protein kinase, Ser/Thr (non-receptor) P08413 24245 14q21 rat T325-p 48915805 RQTTAPAtMSTAASG molecular association, regulation 26291163 1 1 0 inhibits interaction with F-actin, regulates synaptic plasticity -IGF1R IGF1R EC 2.7.10.1; KINASE; Kinase, protein; Membrane protein, integral; Protein kinase, TK; Protein kinase, tyrosine (receptor) NP_999337 397350 pig Y1161-p 448386 FGMTRDIyETDYYRK PK_Tyr_Ser-Thr activity, induced 14976148 22 31 455 -EGFR EGFR EC 2.7.10.1; KINASE; Kinase, protein; Membrane protein, integral; Oncoprotein; Protein kinase, TK; Protein kinase, tyrosine (receptor) P00533 1956 7p11.2 human K739-ub 1065312 IPEGEKVkIPVAIKE PK_Tyr_Ser-Thr protein degradation 17940017 1 3 0 -TLR4 TLR4 Membrane protein, integral; Receptor, misc. O00206 7099 9q33.1 human R812-m2 1881518206 HIFWRRLrKALLDGK transcription, induced 34583098 1 0 0 IFN-? production in TLR4-/-BMDM cells -CIITA CIITA DNA-binding; EC 2.7.11.1; KINASE; Protein kinase, Ser/Thr (non-receptor); Transcription, coactivator/corepressor P33076 4261 16p13.13 human S834-p 448443 QELPGRLsFLGTRLT transcription, altered 11416140 1 1 0 -FBP1 FBPase Carbohydrate Metabolism - fructose and mannose; Carbohydrate Metabolism - glycolysis and gluconeogenesis; Carbohydrate Metabolism - pentose phosphate pathway; EC 3.1.3.11; Mitochondrial; Phosphatase (non-protein) P09467 2203 9q22.32 human S63-p 55578726 HLYGIAGsTNVTGDQ FBPase enzymatic activity, inhibited 27153534 1 1 0 -MERTK Mer EC 2.7.10.1; KINASE; Kinase, protein; Membrane protein, integral; Oncoprotein; Protein kinase, TK; Protein kinase, tyrosine (receptor) Q12866 10461 2q13 human Y749-p 449988 FGLSKKIySGDYYRQ PK_Tyr_Ser-Thr enzymatic activity, induced 8702477 1 13 435 -Dok2 DOK2 Adaptor/scaffold O70469 13449 14 D2|14 36.71 cM mouse Y351-p 447615 APLPDHIyDEPEGVA molecular association, regulation cell differentiation, altered; cell growth, altered NCK1(NOT_REPORTED); NCK1(INDUCES) 10428862; 10508618; 11689432; 12093790; 9764820 6 0 25 -H2AX H2AX DNA repair, damage; DNA-binding; Helicase P16104 3014 11q23.3 human K118-ub 3945263 IQAVLLPkKTSATVG Histone_H2A_C molecular association, regulation; intracellular localization; phosphorylation cell cycle regulation; DNA repair, induced UBE2T(INDUCES) 21690091; 33087136 6 15 167 ATM recruitment, H2AX S139 phosphorylation ; CHK1 phosphorylation and activation, cell cycle arrest, the DNA damage response and radioresistance -Mybpc3 MYBPC3 Myosin-binding O70468 17868 2|2 E1 mouse S282-p 471080 AGAGRRTsDSHEDAG activity, induced; molecular association, regulation; intracellular localization; protein conformation; phosphorylation apoptosis, altered; cytoskeletal reorganization MYH1(DISRUPTS); MYBPC1(DISRUPTS) 17075052; 21597010; 21978630; 22752314; 24001940; 24951619; 25740838; 26908877; 28167762; 31142654; 31796859 35 8 28 primes phosphorylation at other sites -RBM17 RBM17 RNA splicing; RNA-binding; Spliceosome Q96I25 84991 10p15.1 human S202-p 27936104 EEDSRPRsQSSKAAI molecular association, regulation; phosphorylation cell motility, induced; RNA stability, induced RNA(DISRUPTS) 23519612 1 0 0 induced cell invasion, enhanced Cortactin phosphorylation at ERK-dependent sites -Cacna1d CACNA1D Channel, calcium; Membrane protein, integral; Membrane protein, multi-pass P27732 29716 16p16 rat S1964-p 4771088 PPSHRRSsFNFECLR CAC1F_C activity, induced 18690020 2 1 0 enhancement of the current -Tfcp2l1 TFCP2L1 DNA-binding Q3UNW5 81879 1|1 E2.3 mouse S393-p 1875342302 LPQKQDDsGDNSLCV protein degradation; molecular association, regulation; ubiquitination; intracellular localization cell differentiation, induced BTRC(INDUCES) 34731635 1 0 0 -Slc40a1 SLC40A1 Membrane protein, integral; Membrane protein, multi-pass; Transporter; Transporter, SLC family Q9JHI9 53945 1|1 C1.1 mouse K253-ub 1872325200 LKQLTSPkDTEPKPL FPN1 receptor internalization, induced; protein degradation 17541408 1 0 0 SLC401A K253 internalization; regulation of iron transport (promotes aceruloplasminemia-an iron overload disease) -FANCL FANCL EC 6.3.2.-; EC 6.3.2.19; Ligase; UBIQUITIN LIGASE; Ubiquitin conjugating system; Ubiquitin ligase Q9NW38 55120 2p16.1 human T178-p 63128909 VPFCASWtPQSSLIS FANCL_d2 protein stabilization 23783032 1 0 0 -PXN PXN Adaptor/scaffold; Cell adhesion; Cytoskeletal; Motility/polarity/chemotaxis P49023 5829 12q24.23 human S272-p 465466 ELDELMAsLSDFKIQ molecular association, regulation cell adhesion, induced; cytoskeletal reorganization; transcription, inhibited TACE(INDUCES) 23317503; 32139877; 32155329 12 12 0 -PARD3 PAR3-alpha Adaptor/scaffold; Motility/polarity/chemotaxis Q8TEW0 56288 10p11.22-p11.21 human S873-p 3207429 VDDQKAGsPSRDVGP molecular association, regulation GAB1(DISRUPTS) 22883624 1 32 2 -NR1I2 PXR DNA-binding; Nuclear receptor O75469 8856 3q13.33 human K170-ac 1873076600 DTTFSHFkNFRLPGV intracellular localization cell motility, induced; cell adhesion, induced 28623334 1 0 0 TIP60-PXR complex -SMURF2 SMURF2 EC 6.3.2.-; EC 6.3.2.19; Ligase; UBIQUITIN LIGASE; Ubiquitin conjugating system; Ubiquitin ligase Q9HAU4 64750 17q23.3-q24.1 human K26-sm 52415801 LCAKNLVkKDFFRLP C2 signaling pathway regulation 26679521 2 0 0 regulation of TGF-beta induced epithelial-mesenchymal transition -LMNA lamin A/C Cytoskeletal P02545 4000 1q22 human S12-p 469170 SQRRATRsGAQASST molecular association, regulation lamin A/C(DISRUPTS) 35839855 1 38 17 -CDC25C CDC25C EC 3.1.3.48; Motility/polarity/chemotaxis; PHOSPHATASE; Protein phosphatase, dual-specificity P30307 995 5q31.2 human S214-p 448417 SRSGLYRsPSMPENL M-inducer_phosp molecular association, regulation; enzymatic activity, induced cell cycle regulation; cell adhesion, altered 14-3-3 beta(DISRUPTS) 12766774; 20530684; 8119945 4 6 10 -SF3B1 SF3B1 RNA splicing; RNA-binding; Spliceosome O75533 23451 2q33.1 human T248-p 455542 GSETPGAtPGSKIWD molecular association, regulation NIPP-1(INDUCES) 12105215 1 31 6 -MCM3 MCM3 DNA replication; EC 3.6.4.12 P25205 4172 6p12.2 human K270-ub 58948906 CNVKQMSkDAQPSFS cell cycle regulation 27621311 1 2 0 KEAP1-MCM3 associates with chromatin in a cell cycle-dependent manner -ELAVL1 HuR RNA-binding Q15717 1994 19p13.2 human S221-p 478357 QAQRFRFsPMGVDHM molecular association, regulation; intracellular localization; phosphorylation translation, altered; apoptosis, induced; RNA stability, induced; cell motility, altered; RNA stability, altered 14-3-3 theta(INDUCES); PKCA(INDUCES) RNA(INDUCES) 17392515; 18285462; 20086103; 23978401; 24492650; 28383062; 34406862; 34863979 11 0 0 -TBC1D4 AS160 GAP; GAP, Rab O60343 9882 13q22.2 human S751-p 455924 EGRKRTSsTCSNESL molecular association, regulation 14-3-3 epsilon(INDUCES) 20410134 10 10 48 multiple sites (6P) mutant -KCNK18 KCNK18 Channel, ligand-gated; Channel, potassium; Membrane protein, integral; Membrane protein, multi-pass Q7Z418 338567 10q25.3 human S262-p 13383300 ELVLGRLsYSIISNL intracellular localization; activity, inhibited transcription, inhibited 25202008; 30327410 4 0 0 -MARK3 MARK3 EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, CAMK; Protein kinase, Ser/Thr (non-receptor) P27448 4140 14q32.32-q32.33 human S215-p 450315 KLDTFCGsPPYAAPE Pkinase enzymatic activity, induced 12879020 2 11 12 -MAP1S BPY2-IP1 Apoptosis; Microtubule-binding Q66K74 55201 19p13.11 human K520-ac 1872903200 RKTEKEAkTPRELKK protein stabilization autophagy, induced 28386016 1 0 0 -XIAP XIAP Apoptosis; EC 6.3.2.-; Ligase; UBIQUITIN LIGASE; Ubiquitin conjugating system; Ubiquitin ligase P98170 331 Xq25 human S40-p 31884865 FANFPSGsPVSASTL BIR molecular association, regulation apoptosis, induced CASP3(DISRUPTS); CASP7(DISRUPTS) 27927753 1 1 0 -NR4A1 Nur77 Apoptosis; DNA-binding; Nuclear receptor P22736 3164 12q13.13 human T48-p 41583605 EAAPAAPtALPSFST cell motility, induced; cell growth, induced; cytoskeletal reorganization 26155943 1 0 0 required for increase in cell growth, cell motility, monolayer permeability, and formation of actin stress fibers. -MKNK1 Mnk1 EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, CAMK; Protein kinase, Ser/Thr (non-receptor); Translation Q9BUB5 8569 1p33 human T255-p 447622 ITTPELTtPCGSAEY Pkinase enzymatic activity, induced apoptosis, inhibited; cell growth, altered 17130135; 17590453; 18299328 13 1 0 Disruption of Mnk1 Mnk2 enhances As2O4 inducedapoptosis. -PLD1 PLD1 iso2 EC 3.1.4.4; Lipid Metabolism - ether lipid; Lipid Metabolism - glycerophospholipid; Motility/polarity/chemotaxis; Phospholipase Q13393-2 5337 3q26.31 human T147-p 448573 PIPTRRHtFRRQNVR PX intracellular localization; enzymatic activity, induced 16978840 5 0 0 -Ppara PPAR-alpha DNA-binding; Nuclear receptor; UBIQUITIN LIGASE P23204 19013 15 E2|15 40.42 cM mouse S12-p 1789802 ESPICPLsPLEADDL activity, induced 33214136 3 0 0 -Grik5 GluR KA2 Channel, ligand-gated; Membrane protein, integral; Membrane protein, multi-pass Q63273 24407 1q21 rat S840-p 31033001 SAESEEVsVCQEMLQ activity, induced 23066089 1 0 0 GluR KA2 mediated potentiation of heteromeric KARs -ERCC4 ERCC4 DNA repair, damage; Deoxyribonuclease; EC 3.1.-.- Q92889 2072 16p13.12 human K911-ac 1877232000 SFAEVVSkGKGKK__ molecular association, regulation DNA repair, induced ERCC1(INDUCES) 32034146 1 1 0 -RAF1 RAF1 EC 2.7.11.1; KINASE; Kinase, protein; Oncoprotein; Protein kinase, Ser/Thr (non-receptor); Protein kinase, TKL P04049 5894 3p25.2 human S499-p 450237 VKSRWSGsQQVEQPT PK_Tyr_Ser-Thr phosphorylation; enzymatic activity, induced 10998357; 8321321 2 0 0 may be required for S259 autophosphorylation -PRDX6 PRDX6 Amino Acid Metabolism - phenylalanine; EC 1.11.1.15; EC 1.11.1.9; Energy Metabolism - methane; Oxidoreductase; Phospholipase P30041 9588 1q25.1 human K142-sm 62925701 FVFGPDKkLKLSILY AhpC-TSA sumoylation; protein degradation 28055018 1 0 0 -DLC1 DLC1 GAP; GAP, Rac/Rho; Tumor suppressor Q96QB1 10395 8p22 human S745-p 37037500 TQTSSSSsQSETSSA activity, induced; molecular association, regulation; phosphorylation cell motility, inhibited 25525271 1 0 0 Phosphorylation at T738 and S745 is essential for DLC1-PP2A binding and dephosphorylation -Hmga1 HMGA1 DNA-binding Q8K585 117062 20p12 rat T78-p 451516 KTRKVTTtPGRKPRG molecular association, regulation DNA(DISRUPTS) 10617144 3 7 2 -MMP14 MMP14 EC 3.4.24.80; Membrane protein, integral; Motility/polarity/chemotaxis; Protease P50281 4323 14q11.2 human K581-ub 23299300 CQRSLLDkV______ DUF3377 intracellular localization 22315223 1 0 0 modulates trafficking and cell surface recycling of the protease, degradation of and invasion through type-I collagen -Ret Ret EC 2.7.10.1; KINASE; Kinase, protein; Membrane protein, integral; Oncoprotein; Protein kinase, TK; Protein kinase, tyrosine (receptor) P35546 19713 6 F1|6 55.86 cM mouse S697-p 451267 SSGTRRPsLDSTENQ activity, induced; phosphorylation cell motility, altered; cytoskeletal reorganization 17050626 5 7 0 S697A mice show aganglionosis in the distal colon due to an impaired migration of ENCCs. ENCCs lack chemoattraction to GDNF in culture, fewer GDNF-induced lamellipodia, and JNK activation. -HOXA10 HOXA10 DNA-binding; Transcription factor P31260 3206 7p15.2 human Y343-p 455550 GRKKRCPyTKHQTLE Homeodomain molecular association, regulation; activity, inhibited transcription, induced HOXA10(INDUCES) 12145285 1 0 0 phosphorylation decreases Hox-A10 DNA binding affinity and transcriptional repression activity. -RIPK1 RIPK1 EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, Ser/Thr (non-receptor); Protein kinase, TKL Q13546 8737 6p25.2 human D324-ca 31845900 RMQSLQLdCVAVPSS activity, inhibited apoptosis, induced 10521396 1 0 0 blockage of TNF-induced NF-kB activation -PECAM1 PECAM-1 Cell adhesion; Cell development/differentiation; Membrane protein, integral; Motility/polarity/chemotaxis P16284 5175 17q23.3 human Y713-p 448760 KKDTETVySEVRKAV activity, induced; molecular association, regulation; intracellular localization endocytosis, induced; cell motility, altered; cytoskeletal reorganization; cell adhesion, altered STAT5A(INDUCES); SH2D1B(NOT_REPORTED); SHP-2(INDUCES); Arg(NOT_REPORTED) 10704309; 11254359; 11927609; 12207897; 12535670; 15201144; 18182571; 23322602; 9298995; 9312087 14 20 786 internalization, stimulate actin stress fiber formation; induces switch from heterophilic to homophilic cell-cell aggregation -Trpm2 TRPM2 Channel, calcium; EC 3.6.1.13; Hydrolase; Membrane protein, integral; Membrane protein, multi-pass; Transporter Q91YD4 28240 10 C1|10 39.72 cM mouse T738-p 1879806400 GGIQAFLtKVWWGQL activity, induced 36042566 1 0 0 increases temperature threshold for activation -CTTN Cortactin Actin-binding; Cytoskeletal; Motility/polarity/chemotaxis Q14247 2017 11q13.3 human Y486-p 447704 YPAEDSTyDEYENDL molecular association, regulation cell motility, induced; cell adhesion, altered; cytoskeletal reorganization N-WASP(INDUCES) 15056655; 24188565; 29133485; 9748248 25 1 3 invadopodia formation; Tyrosine phosphorylation is necessary for enhanced S1P barrier enhancement. ; ECM invasion as well as transwell and 2D migration; Regulates membrane ruffling; required for maximal invasion of host cells by C.jejuni; Previous work by the authors showed that src attenuates the actin cross-linking activity of cortactin. These studies show that transfection with a cortactin mutant (F421/F470/F486) impairs the motility of endothelial cells. -Klf1 KLF1 C2H2-type zinc finger protein; DNA-binding; Transcription factor P46099 16596 8 41.3 cM|8 C3 mouse S50-p 31953300 PPNPTGPsLHVSLKS sumoylation; molecular association, regulation; intracellular localization KPNB1(INDUCES) 24576425 1 1 0 nuclear import of KLF1 by sumoylation at K56 -H3c1 H3 DNA-binding P68433 360198 13|13 A3.1 mouse K4-m1 1458622 ____ARTkQTARKST Histone endocytosis, altered; cell differentiation, induced; chromatin organization, altered; cell adhesion, altered; transcription, induced; transcription, altered 20543957; 29370269; 33195484 44 10 9 axon guidance -FSCN1 fascin Actin-binding; Cytoskeletal; Motility/polarity/chemotaxis Q16658 6624 7p22.1 human K471-ac 11324304 KVGGRYLkGDHAGVL Fascin cytoskeletal reorganization; cell motility, inhibited 34555274 1 4 0 inhibited cancer cell migration and tumor metastasis, modulating its bundling to F-actin -DUSP1 DUSP1 EC 3.1.3.16; EC 3.1.3.48; Motility/polarity/chemotaxis; PHOSPHATASE; Protein phosphatase, dual-specificity P28562 1843 5q35.1 human S364-p 448661 LQSPITTsPSC____ protein stabilization 10617468; 25204653 2 0 0 -ARHGEF2 ARHGEF2 iso2 GEF; GEF, Rac/Rho; Motility/polarity/chemotaxis Q92974-2 9181 1q22 human S959-p 467500 SRLSPPHsPRDFTRM activity, inhibited carcinogenesis, induced; cell motility, induced; cytoskeletal reorganization 22072711; 24043311 3 46 13 -Csnk1g2 CK1G2 EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, CK1; Protein kinase, Ser/Thr (non-receptor) Q8BVP5 103236 10|10 C1 mouse T215-p 1871246001 EHKSLTGtARYMSIN Pkinase molecular association, regulation; phosphorylation RIPK3(INDUCES) 33206046 1 1 0 inhibits phosphorylation of MLKL, binding to RIPK3 inhibits RIPK3 binding to RIPK1 -BECN1 beclin 1 Adaptor/scaffold; Autophagy; Membrane protein, peripheral Q14457 8678 17q21.31 human K402-ub 21129894 RMDVEKGkIEDTGGS APG6 protein degradation autophagy, inhibited 28445460 1 4 0 caused by mutant polyQ proteins -Crebbp CBP ACETYLTRANSFERASE; Acetyltransferase; DNA-binding; EC 2.3.1.48; Motility/polarity/chemotaxis; Nuclear receptor co-regulator; Transcription, coactivator/corepressor P45481 12914 16 A1|16 2.4 cM mouse Y1126-p 55377870 QLLGIPDyFDIVKNP Bromodomain cell differentiation, induced; signaling pathway regulation 30573679 1 2 0 regulates T-cell responses to infection, cytokine signaling pathway -ETS1 Ets-1 DNA-binding; Motility/polarity/chemotaxis; Oncoprotein; Transcription factor P13474 396235 chicken S282-p 449317 QSLQRVPsYDSFDSE Ets1_N_flank activity, inhibited 7961750 7 10 87 The in vitro interaction of Ets-1 with a high-affinity Ets binding site was assayed with EMSA. -SLC12A5 KCC2 Membrane protein, integral; Membrane protein, multi-pass; Transporter; Transporter, SLC family Q9H2X9 57468 20q13.12 human Y1110-p 3087801 NRNGDENyMEFLEVL SLC12 activity, inhibited 10942735 3 0 0 -LAT LAT iso2 Adaptor/scaffold; Membrane protein, integral O43561-2 27040 16p11.2 human Y191-p 448005 SLDGSREyVNVSQEL LAT activity, induced; molecular association, regulation; phosphorylation cell differentiation, altered; cell adhesion, altered; signaling pathway regulation; transcription, altered GRB2(INDUCES); PLCG1(INDUCES); GADS(INDUCES); THEMIS(INDUCES); TSAd(INDUCES) 11395491; 12496416; 15029250; 15100278; 23460737; 24412752; 27896837; 30510001; 34161759 40 4 54 induces Erk and calcium signaling -Pxn PXN Adaptor/scaffold; Cell adhesion; Cytoskeletal; Motility/polarity/chemotaxis Q8VI36 19303 5 F|5 56.1 cM mouse S250-p 3653284 SSPQRVTsSQQQTRI Paxillin intracellular localization cell motility, induced 23128389 2 3 17 requred for adhesion turnover -GJA1 GJA1 Channel, misc.; Membrane protein, integral; Membrane protein, multi-pass; Motility/polarity/chemotaxis P17302 2697 6q22.31 human S364-p 450183 AIVDQRPsSRASSRA protein conformation 23828237 6 8 0 -TWIST2 TWIST2 Q8WVJ9 117581 2q37.3 human K129-sm 1881202801 QSDEMDNkMTSCSYV protein stabilization cell motility, induced 33791162 1 0 0 ZNF451 promotes EMT, decreases the ubiquitination level of K129 -Cnr1 CNR1 GPCR, family 1; Membrane protein, integral; Membrane protein, multi-pass; Receptor, GPCR P47746 12801 4 A5|4 16.28 cM mouse T461-p 22342304 TVKIAKVtMSVSTDT receptor desensitization, induced 22014214 1 0 1 -GIT1 GIT1 GAP; GAP, ARF; Motility/polarity/chemotaxis Q9Y2X7 28964 17q11.2 human Y246-p 12243296 PDHKNGHyIIPQMAD molecular association, regulation; protein conformation; activity, inhibited cell motility, induced PXN(INDUCES) 24699139 1 1 0 -DEPTOR DEPTOR Apoptosis Q8TB45 64798 8q24.12 human T259-p 9764733 SHDNRKStSFMSVSP protein degradation; molecular association, regulation carcinogenesis, induced; apoptosis, inhibited; signaling pathway regulation mTOR(DISRUPTS) 19446321 2 2 0 PI3K-Akt signaling -APC2 APCL Membrane protein, peripheral O95996 10297 19p13.3 human S1164-p 23082768 LVLSRCSsVSSLGSF APC_r protein degradation; molecular association, regulation transcription, inhibited axin 1(INDUCES) 24722208 1 0 1 -EIF2AK2 PKR EC 2.7.10.2; EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, Other; Protein kinase, Ser/Thr (non-receptor); Protein kinase, tyrosine (non-receptor); Translation P19525 5610 2p22.2 human S542-p 15413409 TLTVWKKsPEKNERH phosphorylation carcinogenesis, induced; carcinogenesis, inhibited; cell motility, induced; cell growth, induced; apoptosis, induced; apoptosis, inhibited 32812257; 34799660 2 7 2 -NSD2 WHSC1 Amino Acid Metabolism - lysine degradation; EC 2.1.1.43; METHYLTRANSFERASE; Methyltransferase; Methyltransferase, protein lysine; Oncoprotein; Ubiquitin conjugating system O96028 7468 4p16.3 human S102-p 481737 DAKLRFEsQEMKGIG molecular association, regulation; methylation; intracellular localization MDC1(INDUCES); AGO2(INDUCES) 21293379; 26822153 2 6 1 -Foxo4 FOXO4 DNA-binding; Oncoprotein; Transcription factor Q9WVH3 54601 X D|X 43.89 cM mouse K189-ac 459043 PDGGKGGkAPRRRAA transcription, inhibited 16012755 2 1 0 -HIF1A HIF1A Autophagy; DNA-binding; Transcription factor Q16665 3091 14q23.2 human K19-ac 25126719 KISSERRkEKSRDAA protein degradation transcription, inhibited 21917920; 28319066 2 0 0 -Traf4 TRAF4 Adaptor/scaffold; DNA-binding; UBIQUITIN LIGASE; Ubiquitin conjugating system; Ubiquitin ligase Q61382 22032 11|11 B5 mouse K190-ub 40323300 HATSECPkRTQPCAY intracellular localization; enzymatic activity, induced carcinogenesis, induced; cell motility, induced 23760265 1 1 0 -Slc1a2 GLT1 Membrane protein, integral; Membrane protein, multi-pass; Transporter; Transporter, SLC family P31596 29482 3q32 rat K497-ub 4667702 GIVYHLSkSELDTID receptor internalization, induced; protein degradation 18805448 1 1 1 -RACGAP1 MgcRacGAP GAP; GAP, Rac/Rho Q9H0H5 29127 12q13.12 human S149-p 3211986 RLSTIDEsGSILSDI enzymatic activity, induced cell cycle regulation 35477750 1 3 0 induces Rho GTPase activity -Camk2b CAMK2B EC 2.7.11.17; KINASE; Kinase, protein; Protein kinase, CAMK; Protein kinase, Ser/Thr (non-receptor) P08413 24245 14q21 rat T328-p 34358436 TAPATMStAASGTTM molecular association, regulation 26291163 1 1 1 inhibits interaction with F-actin, regulates synaptic plasticity -Pln PLB Inhibitor; Membrane protein, integral P61016 64672 20q11 rat S16-gl 14738100 RSAIRRAsTIEMPQQ Phospholamban molecular association, regulation SERCA2(INDUCES) 20484118 1 0 0 PUGNAc tereatment -ARHGEF7 ARHGEF7 GEF; GEF, Rac/Rho; Motility/polarity/chemotaxis Q14155 8874 13q34 human S518-p 454356 LSASPRMsGFIYQGK PH exocytosis, induced 25009260 2 102 7 dopamine release -RELA NFkB-p65 DNA-binding; Nuclear receptor co-regulator; Transcription factor Q04206 5970 11q13.1 human S316-p 31880654 FKSIMKKsPFSGPTD activity, induced; intracellular localization transcription, induced 26082493 1 3 0 nuclear translocation -KAT5 Tip60 ACETYLTRANSFERASE; Acetyltransferase; EC 2.3.1.48; Nuclear receptor co-regulator; Nucleolus Q92993 10524 11q13.1 human K104-ac 33362432 ASAQASGkTLPIPVQ protein degradation; intracellular localization apoptosis, altered 25301942 1 3 0 HDAC3 increased the TIP60 half-life, and the ubiquitination level of TIP60, nuclear localization, cytoplasm and nucleus with HDAC3 expressed, TIP60 deacetylation increases its resistance to apoptosis -RIGI RIGI EC 3.6.4.13; Hydrolase O95786 23586 9p21.1 human S855-p 17484201 PKPKQFSsFEKRAKI RIG-I_C-RD molecular association, regulation; enzymatic activity, inhibited RIGI(DISRUPTS) 21068236 2 3 0 dephosphorylation of T770, S855, S854 stimulates multimer formation; -PARK7 DJ-1 EC 3.4.-.-; Nuclear receptor co-regulator; Transcription regulation; Tumor suppressor Q99497 11315 1p36.23 human T154-p 2566111 EKDGLILtSRGPGTS DJ-1_PfpI protein stabilization; molecular association, regulation; intracellular localization DJ-1(INDUCES) 31353306 2 3 0 -HHEX HHEX DNA-binding; Transcription factor Q03014 3087 10q23.33 human S177-p 7430501 LAKMLQLsERQVKTW Homeodomain molecular association, regulation transcription, induced DNA(INDUCES) 19324893 2 0 0 -Atoh1 ATOH1 Cell development/differentiation; DNA-binding; Transcription factor P48985 11921 6 C1|6 30.03 cM mouse Y78-p 386186604 CTARAAQyLLHSPEL protein stabilization cell growth, induced; transcription, induced 29168692 1 1 0 -GTF2A1 GTF2A1 Transcription, coactivator/corepressor P52655 2957 14q31.1 human S281-p 449823 DGTGDTSsEEDEDEE TFIIA transcription, induced 11278496 1 0 0 -TSC2 TSC2 Cell cycle regulation; GAP; GAP, misc.; Nuclear receptor co-regulator; Tumor suppressor P49815 7249 16p13.3 human S1798-p 454016 GQRKRLIsSVEDFTE activity, inhibited 15342917; 27451907 5 16 74 cell survival induced -Musk MUSK EC 2.7.10.1; KINASE; Kinase, protein; Membrane protein, integral; Protein kinase, TK; Protein kinase, tyrosine (receptor) Q62838 rat Y755-p 2848300 NIYSADYyKADGNDA PK_Tyr_Ser-Thr phosphorylation; enzymatic activity, induced 10619845 1 2 0 promotes MuSK phosphorylation; promotes AChRb clustering and phosphorylation -MPL MPL Membrane protein, integral; Receptor, cytokine P40238 4352 1p34.2 human Y631-p 450266 HSYLPLSyWQQP___ molecular association, regulation carcinogenesis, induced; cell differentiation, induced; signaling pathway regulation tensin 2(INDUCES) 21527831; 33384332; 36229456 8 0 0 regulates TPO mediated signaling; regulates TPO-R signaling -Kcnj11 Kir6.2 Channel, potassium; Membrane protein, integral; Membrane protein, multi-pass Q61743 16514 7 B3|7 29.66 cM mouse T224-p 453090 MQVVRKTtSPEGEVV IRK_C activity, induced 10698936 3 0 0 -ATF2 ATF-2 ACETYLTRANSFERASE; C2H2-type zinc finger protein; EC 2.3.1.48; Transcription factor P15336 1386 2q31.1 human S62-p 451440 FGPARNDsVIVADQT activity, induced; protein stabilization transcription, induced 15105425 2 9 29 -ABCF1 ABCF1 RNA-binding; Translation Q8NE71 23 6p21.33 human S109-p 453457 KKLSVPTsDEEDEVP molecular association, regulation 17894550 1 105 8 S109 aqnd S140 phosphorylation may affect ABCF1-eIF2 binding to 60S 80S subunits and small polysomes. -PTPN11 SHP-2 EC 3.1.3.48; Motility/polarity/chemotaxis; PHOSPHATASE; Protein phosphatase, tyrosine (non-receptor) Q06124 5781 12q24.13 human Y62-p 449573 KIQNTGDyYDLYGGE SH2 molecular association, regulation; protein conformation; phosphorylation; enzymatic activity, induced carcinogenesis, inhibited; signaling pathway regulation Other(DISRUPTS) 33727228; 35311954 1 70 2048 inhibits binding to SHP099, regulates ERK phosphorylation; inhibits PI3K/AKT pathway and induces activation of the RAS/MAPK signaling -SREBF1 SREBP-1 iso3 DNA-binding; Membrane protein, integral; Membrane protein, multi-pass; Transcription factor P36956-3 6720 17p11.2 human S93-p 469986 YPSMPAFsPGPGIKE transcription, induced 25353341 5 6 0 mRNA expression of central SREBP-1 target genes; Phosphorylation interferes with lipid metabolism and the secretory activity of liver cells. -ACIN1 acinus Apoptosis; RNA splicing; RNA-binding; Spliceosome Q9UKV3 22985 14q11.2 human S1180-p 456759 GPRSRSRsRDRRRKE RSB_motif intracellular localization transcription, induced 18559500 4 2 0 -FGFR1 FGFR1 EC 2.7.10.1; KINASE; Kinase, protein; Membrane protein, integral; Oncoprotein; Protein kinase, TK; Protein kinase, tyrosine (receptor) P11362 2260 8p11.23 human Y463-p 448641 MLAGVSEyELPEDPR molecular association, regulation cell cycle regulation; transcription, altered; cell growth, altered CRK(INDUCES) 10464310; 9880324 6 4 8 Phosphorylation of either Y463 or Y730, dispensable for mitogenic signaling, represents an absolute requirement for FGF2-mediated uPA induction -CCR7 CCR7 GPCR, family 1; Membrane protein, integral; Membrane protein, multi-pass; Motility/polarity/chemotaxis; Receptor, GPCR P32248 1236 17q21.2 human T373-p 455288 MSVEAETtTTFSP__ phosphorylation 15054093 1 0 0 ERK1/2 phosphorylation -SSB SSB Transcription initiation complex P05455 6741 2q31.1 human K41-sm 12004401 KFLKEQIkLDEGWVP La molecular association, regulation; intracellular localization DNAH1(INDUCES); KIF5B(DISRUPTS) RNA(INDUCES) 17646655; 27224031 2 0 0 No difference in CK2-dependent SSB phosphorylation at S366 in K41R/200R mutant and WT; induces retrograde transport -SLC12A1 NKCC2 Membrane protein, integral; Membrane protein, multi-pass; Transporter; Transporter, SLC family P55015 100328575 rabbit T99-p 458227 TNTYYLQtFGHNTMD AA_permease_N activity, induced 16077079 15 2 0 -PAX3 PAX3 DNA-binding; Oncoprotein; Transcription factor P23760 5077 2q36.1 human K475-ac 25042101 YGQYGQSkPWTF___ molecular association, regulation cell growth, inhibited; cell differentiation, induced; transcription, altered DNA(INDUCES) 21169561 1 0 0 K437 decreases Hes1 transcription, K437 and K475 increase transcription of Neurog2 -MAP3K6 MEKK6 EC 2.7.11.25; KINASE; Kinase, protein; Protein kinase, STE; Protein kinase, Ser/Thr (non-receptor) O95382 9064 1p36.11 human S964-p 4270162 SPPKRCLsYGGTSQL molecular association, regulation 14-3-3 gamma(INDUCES) 19935702 1 6 0 regulation of ASK1 function through the interaction -ESPL1 separase EC 3.4.22.49; Protease Q14674 9700 12q13.13 human T1363-p 1211205 AGPHVPFtVFEEVCP enzymatic activity, inhibited CDK1(INDUCES) 17974570 1 1 0 phosphorylation of S1399 is a key residue in CDK1-dependent inhibition of separase -PGAM1 PGAM1 Carbohydrate Metabolism - glycolysis and gluconeogenesis; EC 3.1.3.13; EC 5.4.2.11; EC 5.4.2.4; Isomerase; Phosphatase (non-protein) P18669 5223 10q24.1 human Y92-p 454756 WRLNERHyGGLTGLN His_Phos_1 enzymatic activity, induced 27991922 3 59 2247 -KIF20A KIF20A Microtubule-binding; Motor O95235 10112 5q31.2 human T857-p 471862 LRNLLPRtPTCQSST molecular association, regulation; intracellular localization; protein conformation cell cycle regulation AurB(DISRUPTS); INCENP(DISRUPTS) 24656812 1 10 35 favours solubility, inhibits microtubule binding -HELLS HELLS Apoptosis; EC 3.6.1.-; EC 3.6.4.-; Helicase Q9NRZ9 3070 10q23.33 human R309-me 1870757300 YHGTQEErQKLVRNI SNF2-rel_dom carcinogenesis, inhibited 32994405 1 1 0 -EIF2AK2 PKR EC 2.7.10.2; EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, Other; Protein kinase, Ser/Thr (non-receptor); Protein kinase, tyrosine (non-receptor); Translation P19525 5610 2p22.2 human T89-p 3753307 VSPLLLTtTNSSEGL enzymatic activity, induced 11152499 1 1 0 -Fndc5 FNDC5 Membrane protein, integral Q8K4Z2 384061 4|4 D2.2 mouse K185-ac 1881215701 DNEPNNNkEKTKSAS ubiquitination 33754067 1 0 0 SIRT2-dependent deacetylation and deubiquitination increases stability -HBP1 HBP1 DNA-binding; Transcription factor O60381 26959 7q22.3 human S380-p 3252925 MARQRRAsLSCGGPG activity, induced; protein stabilization cell growth, inhibited; apoptosis, induced; transcription, altered DNA(INDUCES) 28348080 1 10 53 HBP1-mediated DNMT1 repression and p16 activation -RAB11FIP5 RAB11FIP5 Cytoskeletal Q9BXF6 26056 2p13.2 human T276-p 32674000 GPGAELLtRSPSRSS molecular association, regulation; intracellular localization cell cycle regulation SNX18(DISRUPTS) 24591568 1 0 0 regulates apical lumen formation -SKP2 SKP2 Cell cycle regulation; UBIQUITIN LIGASE; Ubiquitin conjugating system; Ubiquitin ligase Q13309 6502 5p13.2 human K71-ac 25673100 SPPRKRLkSKGSDKD protein stabilization; intracellular localization carcinogenesis, induced; cell motility, induced SKP2(INDUCES) 22770219; 23230084 2 0 0 -KMT2E MLL5 Cell cycle regulation; EC 2.1.1.43; METHYLTRANSFERASE; Methyltransferase; Methyltransferase, protein lysine; Transcription, coactivator/corepressor Q8IZD2 55904 7q22.3 human T440-gl 7482007 IHSIPKGtEITIAFD SET methylation; enzymatic activity, induced cell differentiation, induced; transcription, induced 19377461 1 0 0 increases methylation at H3K4, induces retinoic acid-induced granulopoiesis -CTH CTH Amino Acid Metabolism - cysteine and methionine; Amino Acid Metabolism - glycine, serine and threonine; Cell cycle regulation; EC 4.4.1.1; Energy Metabolism - nitrogen; Lyase; Other Amino Acids Metabolism - selenoamino acid P32929 1491 1p31.1 human K73-ac 19011380 PTRNCLEkAVAALDG Cys_Met_Meta_PP protein stabilization 32755037 1 1 0 K70R mutant is resistant to both acetylation and ubiquitination and is more stable than WT -PLCB3 PLCB3 Carbohydrate Metabolism - inositol phosphate; EC 3.1.4.11; Phospholipase Q01970 5331 11q13.1 human S537-p 448450 PSLEPQKsLGDEGLN cell motility, induced 35884879 6 36 7 -MAX MAX DNA-binding; Transcription factor P61244 4149 14q23.3 human K153-ac 474515 PEEPQSRkKLRMEAS molecular association, regulation; intracellular localization transcription, induced B-Myc(INDUCES) DNA(DISRUPTS) 17217336 1 1 0 -CTTN Cortactin Actin-binding; Cytoskeletal; Motility/polarity/chemotaxis Q14247 2017 11q13.3 human K124-ac 461719 SVRGFGGkFGVQMDR HS1_rep molecular association, regulation; intracellular localization cell motility, inhibited ACTB(DISRUPTS) 17643370 1 3 10 Acetylation prevents localization to membrane ruf?es. -EHMT2 EHMT2 Amino Acid Metabolism - lysine degradation; EC 2.1.1.43; METHYLTRANSFERASE; Methyltransferase; Methyltransferase, protein lysine Q96KQ7 10919 6p21.33 human K465-sm 1878097303 GCNAAILkRETMRPS molecular association, regulation; intracellular localization cell cycle regulation; cell growth, induced; transcription, induced PCAF(INDUCES) 30867409 1 0 0 SUMOylated G9a is recruited to E2F1 target gene promoters, EHMT2 is an activator of proliferation and E2F1-target gene expression -ADRA1D ADRA1D GPCR, family 1; Membrane protein, integral; Membrane protein, multi-pass; Receptor, GPCR P25100 146 20p13 human S515-p 1346843001 TQLRAKVsSLSHKIR receptor internalization, induced; molecular association, regulation; intracellular localization; receptor internalization, altered signaling pathway regulation ARRB1(INDUCES) 29551601; 30419287 2 1 0 triggers the calcium signaling pathway; regulates ERK signaling pathway, induces calcium signaling de-sensitization -RPA2 RFA2 DNA replication P15927 6118 1p35.3 human S33-p 448339 GFGSPAPsQAEKKSR molecular association, regulation; intracellular localization; phosphorylation cell cycle regulation; DNA repair, induced; apoptosis, altered; cell growth, induced; DNA repair, inhibited; cell growth, altered WRN(INDUCES); CDC5L(INDUCES) 17035231; 19704001; 19843584; 21107010; 21664290; 23684611; 24332808; 24639502; 24876101; 26237679; 28046023; 33870196; 34385259 45 2 0 -Gabra4 GABRA4 Channel, chloride; Channel, ligand-gated; Membrane protein, integral; Membrane protein, multi-pass; Transporter; Transporter, ion channel Q9D6F4 14397 5|5 C3.1-C3.2 mouse S472-p 17390700 PASLGSAsTRPAFGS Neur_chan_memb protein stabilization; intracellular localization 20940303 2 1 0 increases receptor cell surface expression -PRKN PARK2 EC 6.3.2.-; EC 6.3.2.19; Ligase; Translation; Translation regulation; UBIQUITIN LIGASE; Ubiquitin conjugating system; Ubiquitin ligase O60260 5071 6q26 human S110-p 1872827402 TRVDLSSsVLPGDSV ubiquitination; intracellular localization; phosphorylation; enzymatic activity, induced autophagy, induced 33827825 1 1 0 induces phosphorylation at S65 and ubiquitination of substrates -CDK5 CDK5 Cell cycle regulation; EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, CMGC; Protein kinase, Ser/Thr (non-receptor) Q00535 1020 7q36.1 human T77-p 900975700 LHSDKKLtLVFEFCD Pkinase enzymatic activity, inhibited 29511352 1 0 0 -ERBB4 HER4 EC 2.7.10.1; KINASE; Kinase, protein; Membrane protein, integral; Protein kinase, TK; Protein kinase, tyrosine (receptor) Q15303 2066 2q34 human Y1188-p 451501 QALDNPEyHNASNGP molecular association, regulation GRB2(INDUCES); Arg(INDUCES); SHC1(INDUCES) 16729043; 18721752; 8617750 2 1 0 -L1cam NCAM-L1 Cell adhesion; Membrane protein, integral P11627 16728 X A7.3|X 37.43 cM mouse Y1232-p 10272401 DGSFIGQySGKKEKE Bravo_FIGEY molecular association, regulation cell growth, inhibited ANK1(DISRUPTS) 22579729 5 0 4 -Pdpk1 PDK1 EC 2.7.11.1; KINASE; Kinase, protein; Nuclear receptor co-regulator; Protein kinase, AGC; Protein kinase, Ser/Thr (non-receptor) O55173 81745 10q12 rat Y376-p 447694 SEDDEDCyGNYDNLL enzymatic activity, induced translation, altered; cell adhesion, altered 18559349 9 1 0 Induces fibronectin expression and deposition and increases AngII mesangial cell hypertrophy -RELA NFkB-p65 DNA-binding; Nuclear receptor co-regulator; Transcription factor Q04206 5970 11q13.1 human K123-ub 25087012 LGIQCVKkRDLEQAI RHD_DNA_bind transcription, inhibited 21706061 1 2 0 inhibits acetylation -CDC73 CDC73 Cell cycle regulation; Tumor suppressor Q6P1J9 79577 1q31.2 human Y290-p 3449102 KQPIPAAyNRYDQER CDC73_N molecular association, regulation; protein conformation transcription, inhibited; signaling pathway regulation CTNNB1(DISRUPTS) 21726809 1 0 1 inhibits Wnt signaling pathway -Bcar1 P130Cas Adaptor/scaffold; Motility/polarity/chemotaxis Q61140 12927 8|8 E1 mouse Y253-p 448721 APGPQDIyDVPPVRG carcinogenesis, induced; cell motility, induced; cell motility, altered 20430882; 21963850 14 44 723 SH3 and CCH domains are required for P130Cas tyrosine phosphorylation and promoting cell migration. ; migration, invasion, metastasis -ALK ALK EC 2.7.10.1; KINASE; Kinase, protein; Membrane protein, integral; Oncoprotein; Protein kinase, TK; Protein kinase, tyrosine (receptor) Q9UM73 238 2p23.2-p23.1 human Y1359-p 1016332 KNCPGPVyRIMTQCW PK_Tyr_Ser-Thr molecular association, regulation cell growth, altered Src(INDUCES) 14563642 2 3 5 -CHEK2 Chk2 EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, CAMK; Protein kinase, Ser/Thr (non-receptor); Tumor suppressor O96017 11200 22q12.1 human K249-ac 1878180000 TCKKVAIkIISKRKF enzymatic activity, induced 30902968 1 0 0 DDR-mediated cell death in oxidative stress -Gdpd5 GDPD5 EC 3.1.-.-; Membrane protein, integral; Membrane protein, multi-pass; Phosphodiesterase Q640M6 233552 7|7 E1 mouse T587-p 27930802 ANANSTAtPVGPRNA enzymatic activity, induced 23589856 1 1 0 -TP53 p53 Activator; DNA-binding; Motility/polarity/chemotaxis; Nuclear receptor co-regulator; Transcription factor; Tumor suppressor P04637 7157 17p13.1 human S20-p 447529 PLSQETFsDLWKLLP P53_TAD activity, induced; protein degradation; protein stabilization; molecular association, regulation; intracellular localization; protein conformation; phosphorylation cell cycle regulation; carcinogenesis, induced; apoptosis, altered; cell growth, inhibited; apoptosis, induced; transcription, induced; transcription, altered; cell growth, induced; cell growth, altered S100B(INDUCES); DACH1(INDUCES); S100A1(INDUCES); S100A4(INDUCES); CBP(INDUCES); MDM2(DISRUPTS); S100A6(INDUCES); MED17(INDUCES); p300(INDUCES); Chk2(INDUCES); S100A2(INDUCES) DNA(INDUCES) 10570149; 10673500; 11030628; 11258706; 11397945; 11551930; 11861384; 11896587; 12810724; 12860987; 14665630; 15471885; 15671037; 16651424; 17121812; 17339337; 18778462; 19819244; 20024960; 20962272; 21454683; 23798621; 25584963; 26742101; 27753536; 33514736; 35951367; 36007676 127 2 0 CRp53 -GPBAR1 GPBAR1 GPCR, family 1; Membrane protein, integral; Membrane protein, multi-pass; Receptor, GPCR Q8TDU6 151306 2q35 human S310-p 1877729200 WGRASRDsPGPSIAY molecular association, regulation cell growth, induced; apoptosis, inhibited ARRB1(INDUCES) 35858343 0 1 0 -PRKAA2 AMPKA2 Autophagy; EC 2.7.11.1; EC 2.7.11.27; EC 2.7.11.31; KINASE; Kinase, protein; Protein kinase, CAMK; Protein kinase, Ser/Thr (non-receptor) P54646 5563 1p32.2 human Y436-p 58109404 EWKVVNAyHLRVRRK AdenylateSensor enzymatic activity, inhibited autophagy, inhibited 27626315 1 0 0 TNF induced inhibition of autophagy -Arhgef2 ARHGEF2 GEF; GEF, Rac/Rho; Motility/polarity/chemotaxis Q60875 16800 3|3 F1 mouse S885-p 451365 PLDPRRRsLPAGDAL activity, induced; molecular association, regulation; activity, inhibited cytoskeletal reorganization 14-3-3 beta(INDUCES); DYNLT1(DISRUPTS); 14-3-3 eta(INDUCES) 19667072; 22405273; 24270516; 33740666 12 47 145 -Sstr2 SSTR2 GPCR, family 1; Membrane protein, integral; Membrane protein, multi-pass; Receptor, GPCR P30680 rat T354-p 7652101 KSRLNETtETQRTLL activity, induced; intracellular localization; receptor internalization, altered signaling pathway regulation 21493671; 21795688 9 0 1 Dephosphorylation is initiated directly after receptor activation at or near the plasma membrane; leads to disruption of the ?-arrestin- GPCR complex -CDCA5 CDCA5 Cell cycle regulation Q96FF9 113130 11q13.1 human T48-p 472119 LPEIWPKtPSAAAVR molecular association, regulation cell cycle regulation H2A.1(DISRUPTS); SMC3(DISRUPTS) 21878504 1 3 4 -Psmb4 PSMB4 Cell cycle regulation; Cytoskeletal; EC 3.4.25.1; Protease; Proteasome complex P99026 19172 3 F2.1|3 40.74 cM mouse K201-ac 31910305 LLREVLEkQPVLSQT Proteasome protein degradation 24037710 0 3 0 -MACF1 ACF7 Actin-binding; Cytoskeletal; Motility/polarity/chemotaxis Q9UPN3 23499 1p34.3 human S7234-p 18507013 RAASPTRsSSSASQS intracellular localization cell motility, induced; cytoskeletal reorganization 21295697 1 2 1 inhibits localization along microtubules, alters organization of microtubules, regulates skin wound repair, SC migration -RAB12 RAB12 G protein; G protein, monomeric; G protein, monomeric, Rab Q6IQ22 201475 18p11.22 human S106-p 487152 AGQERFNsITSAYYR Ras autophagy, inhibited 34515301 6 19 13 -DVL3 DVL3 Motility/polarity/chemotaxis Q92997 1857 3q27.1 human S642-p 34668133 RSHHSLAsSLRSHHT Dsh_C intracellular localization 24993822 1 2 0 -POLR2A POLR2A EC 2.7.7.48; EC 2.7.7.6; Nucleotide Metabolism - purine; Nucleotide Metabolism - pyrimidine; Transcription initiation complex; Transferase P24928 5430 17p13.1 human R1810-m2 21329100 SYSPSSPrYTPQSPT RNA_pol_Rpb1_R molecular association, regulation transcription, induced; transcription, inhibited SMN(INDUCES); TDRD3(INDUCES) 21454787; 26700805 2 0 0 -INSR INSR EC 2.7.10.1; KINASE; Kinase, protein; Membrane protein, integral; Protein kinase, TK; Protein kinase, tyrosine (receptor) P06213 3643 19p13.2 human S1354-p 447679 SSLGFKRsYEEHIPY phosphorylation 7615833 2 4 0 No difference between non diabetic normal controls and NIDDM patients InsR phosphorylation at S1354 and T1375 -APEX1 APE1 DNA repair, damage; DNA-binding; Deoxyribonuclease; EC 4.2.99.18; Endoplasmic reticulum; Hydrolase; Lyase; Nuclear receptor co-regulator; Nucleolus; Transcription, coactivator/corepressor P27695 328 14q11.2 human K6-ac 459075 __MPKRGkKGAVAED molecular association, regulation; enzymatic activity, inhibited; enzymatic activity, induced DNA repair, induced; cell growth, induced; DNA repair, inhibited; transcription, inhibited XRCC1(INDUCES); XRCC1(DISRUPTS); LIG3(INDUCES) DNA(INDUCES) 14633989; 19934257; 27655688; 27994014 5 2 0 -Itpka ITPKA Carbohydrate Metabolism - inositol phosphate; EC 2.7.1.127; Kinase, lipid; Motility/polarity/chemotaxis P17105 81677 3q35 rat S119-p 4763186 LQQPRRLsTSSLSST molecular association, regulation neural plasticity; cytoskeletal reorganization EB3(DISRUPTS) 30466786 2 0 0 -STRAP STRAP Adaptor/scaffold; RNA splicing; UBIQUITIN LIGASE; Ubiquitin ligase Q9Y3F4 11171 12p12.3 human S179-p 11267003 ATMTEVKsLNFNMSV phosphorylation apoptosis, altered 19880523 2 0 0 negatively regulates ASK1 phosphorylation and ASK1-mediated signaling -ACBD4 ACBD4 Lipid-binding Q8NC06 79777 17q21.31 human S166-p 13206355 PKEPAPPsPESHSPR molecular association, regulation VAPB(INDUCES) 35019937 1 12 0 -SHC1 SHC1 iso2 Adaptor/scaffold; Apoptosis; Mitochondrial; Motility/polarity/chemotaxis P29353-2 6464 1q21.3 human S29-p 448791 EEWTRHGsFVNKPTR intracellular localization 16963224 4 35 16 after treatment with H2O2, the protein co-localizes with PKCD and co-translocates to the plasma membrane -NPAT NPAT Cell cycle regulation; Transcription regulation Q14207 4863 11q22.3 human T1270-p 2286400 SDLPVPRtPGSGAGE NPAT_C transcription, induced 10995387 1 2 1 multiple sites deletion mutant -Syk Syk EC 2.7.10.2; KINASE; Kinase, protein; Protein kinase, TK; Protein kinase, tyrosine (non-receptor) P48025 20963 13 A5|13 27.41 cM mouse Y130-p 447657 KENLIREyVKQTWNL molecular association, regulation; protein conformation FCER1G(DISRUPTS); ITGAM(DISRUPTS); Bcr(DISRUPTS) 18689684; 30051939; 31216232 7 3 0 -SRCIN1 SNIP Cytoskeletal Q9C0H9 80725 17q12 human Y264-p 456703 IYRKEPLyAAFPGSH AIP3 molecular association, regulation CSK(INDUCES) 23383002 1 5 97 -ATF7 ATF7 C2H2-type zinc finger protein; DNA-binding; Transcription factor P17544 11016 12q13.13 human T53-p 467516 IIADQTPtPTRFLKN protein degradation; molecular association, regulation; ubiquitination; phosphorylation transcription, induced; signaling pathway regulation TAF12(INDUCES) 18950637; 21858082 2 50 27 -NFE2L2 NRF2 DNA-binding; Transcription factor Q16236 4780 2q31.2 human S215-p 10292704 VETTMVPsPEAKLTE protein stabilization; molecular association, regulation; intracellular localization transcription, induced PIN1(INDUCES) 19668370; 34918396 2 7 0 inhibits ubiquitination; moderate effects observed only in NFE2L2-5A mutant -IRS2 IRS2 Adaptor/scaffold; Motility/polarity/chemotaxis Q9Y4H2 8660 13q34 human S306-p 3217341 EFRPRSKsQSSGSSA intracellular localization 34253290 3 39 26 disassociation of IRS2 from plasma membrane to cytosol; limits PM-associated PI3K and PIP3 synthesis -PPARA PPAR-alpha DNA-binding; Nuclear receptor; UBIQUITIN LIGASE Q07869 5465 22q13.31 human K185-sm 11539303 RSEKAKLkAEILTCE molecular association, regulation transcription, inhibited N-CoR1(INDUCES) 19955185 1 0 0 mammalian one-hybrid used for interaction -Mlkl MLKL KINASE; Kinase, protein; Protein kinase, Ser/Thr (non-receptor); Protein kinase, TKL Q9D2Y4 74568 8|8 E1 mouse S347-p 29611200 SKTQNSIsRTAKSTK PK_Tyr_Ser-Thr protein conformation 26024392 3 1 0 -Gabrg2 GABRG2 Channel, chloride; Channel, ligand-gated; Membrane protein, integral; Membrane protein, multi-pass; Transporter; Transporter, ion channel P22723 14406 11 A5|11 24.8 cM mouse K372-ub 11956711 SKDKDKKkKNPLLRM Neur_chan_memb protein degradation; receptor internalization, altered 19815531 1 0 0 regulation of the late endosomal/lysosomal trafficking of GABA receptors, regulation of synaptic transmission -Syn1 SYN1 Vesicle P09951 24949 Xq11 rat S551-p 448377 ARPPASPsPQRQAGP intracellular localization neural plasticity; exocytosis, inhibited; exocytosis, induced 19896987; 24743689; 24849359; 35723394 8 22 10 -SRSF11 SRSF11 RNA processing; RNA splicing; Spliceosome Q05519 9295 1p31.1 human S287-p 470248 KSRSRRRsKSPRRRR protein stabilization; ubiquitination; intracellular localization carcinogenesis, induced; RNA splicing, induced; cell motility, induced 36394206 1 1 0 -ERBB3 HER3 EC 2.7.10.1; KINASE; Kinase, protein; Membrane protein, integral; Oncoprotein; Protein kinase, TK; Protein kinase, tyrosine (receptor) P21860 2065 12q13.2 human Y1199-p 458099 DEDEEYEyMNRRRRH molecular association, regulation GRB2(INDUCES) 16729043 2 2 7 -HLA-B HLAB Immunoglobulin superfamily; Membrane protein, integral P01889 3106 6p21.33 human K335-ub 2793001 AAVMCRRkSSGGKGG receptor internalization, induced; protein degradation 18083706 1 0 0 MHC-I down-regulation of HLAB from the cell surface in cancer cells -MAP3K14 Nik EC 2.7.11.25; KINASE; Kinase, protein; Protein kinase, STE; Protein kinase, Ser/Thr (non-receptor) Q99558 9020 17q21.31 human S817-p 27259013 EKNPSKAsQSSRDTL protein degradation 20501937 2 1 0 IKKA-dependent destabilization of Nik -Rrad RRAD G protein; G protein, monomeric; G protein, monomeric, RGK NP_445790 83521 19p14 rat S25-p 4700219 ERDRRRGsTPWGPAP activity, induced 36215501 2 6 1 induces CaV1.2 activity -MAPT Tau iso8 ACETYLTRANSFERASE; Acetyltransferase; Cytoskeletal P10636-8 4137 17q21.31 human T181-p 447932 KTPPAPKtPPSSGEP molecular association, regulation; intracellular localization; phosphorylation cell growth, inhibited; autophagy, inhibited; cytoskeletal reorganization Tau iso8(INDUCES) 12414518; 15190058; 15664690; 33710538; 33967735; 35857446 107 36 23 -CORO1B coronin 1B Actin-binding; Motility/polarity/chemotaxis Q9BR76 57175 11q13.2 human S2-p 456131 ______MsFRKVVRQ molecular association, regulation cell motility, induced; cytoskeletal reorganization SMTNL2(INDUCES); SSH1(INDUCES); ARPC4(DISRUPTS); ARPC2(DISRUPTS); FKBPL(INDUCES); ARPC2(INDUCES) 16027158; 22619279; 25800056; 27592029; 33275893 7 0 0 -PTEN PTEN Carbohydrate Metabolism - inositol phosphate; EC 3.1.3.16; EC 3.1.3.48; EC 3.1.3.67; Motility/polarity/chemotaxis; Nuclear receptor co-regulator; PHOSPHATASE; Phosphatase, lipid; Tumor suppressor P60484 5728 10q23.31 human K402-ac 5041900 DQHTQITkV______ molecular association, regulation AIP1(INDUCES); DLG1(INDUCES) 18757404 1 0 0 -Ltk LTK EC 2.7.10.1; KINASE; Kinase, protein; Membrane protein, integral; Protein kinase, TK; Protein kinase, tyrosine (receptor) P08923 17005 2 E5|2 59.97 cM mouse Y672-p 472877 RDIYQASyYRKGGRT PK_Tyr_Ser-Thr carcinogenesis, induced; cell growth, induced; apoptosis, inhibited; signaling pathway regulation 34819663 1 3 16 induces AKT/ERK signaling pathway -Homer3 HOMER3 Adaptor/scaffold Q99JP6 26558 8|8 B3.3 mouse S120-p 3879113 ARLAREKsQDGGEFT molecular association, regulation GluR5(DISRUPTS) 26670047 2 6 24 circuit hyperexcitability in fragile X syndrome -HMGN1 HMGN1 DNA-binding; Nuclear receptor co-regulator P05114 3150 21q22.2 human K42-ac 458848 KPKKAAAkDKSSDKK HMG14_17 molecular association, regulation DNA(DISRUPTS) 10753971 1 0 0 -Brsk2 BRSK2 EC 2.7.11.1; EC 2.7.11.26; KINASE; Kinase, protein; Protein kinase, CAMK; Protein kinase, Ser/Thr (non-receptor) Q69Z98 75770 7|7 F5 mouse T464-p 4734913 PAGTPNPtPPSSPSV protein stabilization; enzymatic activity, inhibited; phosphorylation 23790753 1 6 5 inhibits axon branching (activated in BRSK2 18A mutant) -PIAS1 PIAS1 EC 6.3.2.-; Nuclear receptor co-regulator; SUMO LIGASE; SUMO conjugating system; SUMO ligase; Transcription, coactivator/corepressor O75925 8554 15q23 human S510-p 14160798 SPVSRTPsLPAVDTS sumoylation; enzymatic activity, induced 27256105 1 5 0 AMPK activation-induced ML3 SUMOylation -Oprd1 DOR-1 GPCR, family 1; Membrane protein, integral; Membrane protein, multi-pass; Receptor, GPCR P32300 18386 4 D2.3|4 64.78 cM mouse T358-p 449761 ATTRERVtACTPSDG receptor desensitization, altered; intracellular localization; receptor internalization, altered 10973976; 21220103 4 0 0 -Scg5 7B2 Chaperone; Secreted; Secreted, signal peptide P27682 25719 3q35 rat S139-p 457719 APDTAEFsREFQLDQ Secretogranin_V molecular association, regulation; activity, inhibited PCSK2(INDUCES) 16286464 1 5 0 -ARHGDIB RhoGDI beta Cell adhesion; G protein regulator, misc.; Motility/polarity/chemotaxis P52566 397 12p12.3 human Y153-p 7386101 YGPRPEEyEFLTPVE Rho_GDI molecular association, regulation; intracellular localization carcinogenesis, induced; cell motility, induced CDC42(DISRUPTS); RHOA(DISRUPTS); RAC1(DISRUPTS); SELPLG(INDUCES); RHOC(DISRUPTS); VAV1(INDUCES) 19321744; 24055812; 31075185; 32903764 4 1 23 -EGFR EGFR EC 2.7.10.1; KINASE; Kinase, protein; Membrane protein, integral; Oncoprotein; Protein kinase, TK; Protein kinase, tyrosine (receptor) P00533 1956 7p11.2 human T693-p 448054 RELVEPLtPSGEAPN receptor internalization, induced; molecular association, regulation; receptor recycling, induced; receptor internalization, altered; activity, inhibited; phosphorylation cell cycle regulation; signaling pathway regulation EGF(INDUCES) 16785992; 2115882; 2543683; 31395339; 34086370; 36184515; 7505275 19 53 30 regulates phosphorylation of downstream proteins and recycling of FGFR2 -Slc1a1 SLC1A1 Membrane protein, integral; Membrane protein, multi-pass; Transporter; Transporter, SLC family P51907 25550 1q52 rat S465-p 471076 TGIVEKLsKKELEQV activity, induced; intracellular localization 17062570; 19922365 2 0 0 -SLC9A3 NHE3 Membrane protein, integral; Membrane protein, multi-pass; Transporter; Transporter, SLC family P48764 6550 5p15.33 human S555-p 450899 AEGERRGsLAFIRSP receptor internalization, induced; activity, inhibited endocytosis, induced; signaling pathway regulation 23275470 27 5 4 Decrease cell surface expression; Gastrin-CCKBR signal transduction pathway -RB1 Rb Nuclear receptor co-regulator; Oncoprotein; Transcription, coactivator/corepressor; Tumor suppressor P06400 5925 13q14.2 human S838-p 14160962 ILVSIGEsFGTSEKF Rb_C molecular association, regulation cell cycle regulation; chromatin organization, altered; signaling pathway regulation E2F2(INDUCES); E2F1(INDUCES) DNA(DISRUPTS) 33219128 1 3 0 TCR signaling -ATF1 ATF-1 Transcription factor P18846 466 12q13.12 human S63-p 449762 GILARRPsYRKILKD pKID activity, induced; molecular association, regulation; protein conformation transcription, induced; transcription, altered; cell growth, altered PIN1(INDUCES) 12414794; 18794154; 28032861; 9687510 20 2 29 -CDKN1A p21Cip1 Cell cycle regulation; Inhibitor P38936 1026 6p21.2 human K16-ub 9897001 RQNPCGSkACRRLFG protein degradation; ubiquitination cell cycle regulation; carcinogenesis, induced; cell growth, induced 13678583; 17429006; 28446751 5 0 0 -LLGL1 LLGL1 Cell adhesion; Cytoskeletal; Motility/polarity/chemotaxis Q15334 3996 17p11.2 human S659-p 449916 RVKSLKKsLRQSFRR intracellular localization 34717957 2 10 7 -PIAS1 PIAS1 EC 6.3.2.-; Nuclear receptor co-regulator; SUMO LIGASE; SUMO conjugating system; SUMO ligase; Transcription, coactivator/corepressor O75925 8554 15q23 human K315-sm 55435688 SRALIKEkLTADPDS intracellular localization 32047143 1 3 0 -DMAP1 DMAP1 Transcription, coactivator/corepressor Q9NPF5 55929 1p34.1 human Y246-p 998916 EQVAEEEyLLQELRK DMAP1 methylation carcinogenesis, induced; apoptosis, inhibited; transcription, induced BUB3(DISRUPTS) DNA(DISRUPTS) 30553276 1 2 2 methylation inhibited/ blocked -HMGA1 HMGA1 DNA-binding P17096 3159 6p21.31 human T53-p 451515 KEPSEVPtPKRPRGR molecular association, regulation DNA(INDUCES) 17960875 4 55 35 Cdc2 phosphorylated HMGA1 has lower binding affinity than HIPK2 phosphorylated HMGA1. -RPL29 RPL29 Ribosomal; Translation P47914 6159 3p21.2 human K5-m2 35483238 ___MAKSkNHTTHNQ Ribosomal_L29e intracellular localization 29959229 1 1 0 Rpl29K5 methylation as a specific cellular biomarker for SetD7 activity; nuclear localization -WNK1 WNK1 EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, Other; Protein kinase, Ser/Thr (non-receptor) Q9H4A3 65125 12p13.33 human T60-p 450948 EYRRRRHtMDKDSRG activity, induced carcinogenesis, induced; cell growth, induced 16081417; 33744230 8 3 208 -SIRT6 SIRT6 DEACETYLASE; DEUBIQUITINASE; Deacetylase; EC 2.4.2.31; EC 3.5.1.-; Transferase Q8N6T7 51548 19p13.3 human S10-p 23144710 VNYAAGLsPYADKGK DNA repair, induced 27568560 2 8 1 -Actb ACTB Cytoskeletal; Motility/polarity/chemotaxis P60711 81822 12p11 rat S199-p 477773 ILTERGYsFTTTAER Actin intracellular localization cytoskeletal reorganization 31566433 1 9 19 -HIPK2 HIPK2 EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, CMGC; Protein kinase, Ser/Thr (non-receptor) Q9H2X6 28996 7q34 human S441-p 27732203 FFNRDTDsPYPLWRL Pkinase protein conformation 31519758 1 1 0 -Slc9a1 NHE1 Membrane protein, integral; Membrane protein, multi-pass; Motility/polarity/chemotaxis; Transporter; Transporter, SLC family P26431 24782 5q36 rat S776-p 475074 IRSKEPSsPGTDDVF activity, induced 19542484 7 4 0 -GLI1 GLI1 C2H2-type zinc finger protein; Oncoprotein; Transcription factor P08151 2735 12q13.3 human T394-p 1873647704 HGPDAHVtKRHRGDG protein stabilization; molecular association, regulation; intracellular localization carcinogenesis, induced; cell growth, induced; transcription, induced SUFU(DISRUPTS) 34052323 1 1 0 -HMGN1 HMGN1 DNA-binding; Nuclear receptor co-regulator P05114 3150 21q22.2 human S7-p 447788 _MPKRKVsSAEGAAK HMG14_17 intracellular localization 10739259 3 14 18 Phosphorylation facilitates localization to non-nuclear pools. -POLH POLH DNA repair, damage; EC 2.7.7.7; Transferase Q9Y253 5429 6p21.1 human K583-sm 1877365903 PVCEGVSkLEESSKA intracellular localization; enzymatic activity, inhibited 32350109 1 1 0 -CCKBR CCKBR GPCR, family 1; Membrane protein, integral; Membrane protein, multi-pass; Receptor, GPCR P32239 887 11p15.4 human T443-p 17825904 LSYTTIStLGPG___ molecular association, regulation ARRB1(INDUCES) 21156802 1 0 0 -Per1 PER1 Transcription factor O35973 18626 11|11 B3 mouse S661-p 451683 SSSYTASsASDDDKQ intracellular localization 15148313 1 0 0 -Cyp19a1 CYP19A1 EC 1.14.14.14; Lipid Metabolism - androgen and estrogen; Oxidoreductase P28649 13075 9 A5.3|9 29.49 cM mouse S118-p 4661903 HYISRFGsKRGLQCI p450 enzymatic activity, inhibited 18822378 1 0 0 -FLOT1 FLOT1 Adaptor/scaffold O75955 10211 6p21.33 human K195-ub 12252072 GIREAKAkQEKVSAQ protein stabilization; intracellular localization carcinogenesis, induced Snail1(INDUCES) 30631151 1 0 1 translocation of Flot-1 to the nucleus, suppresses proteasomal degradation, promotes epithelial-to-mesenchymal transition (EMT) high metastatic potential -VAMP7 VAMP7 Membrane protein, integral P51809 6845 Xq28 and Yq12 human Y45-p 27806317 SENNKLTySHGNYLF Longin molecular association, regulation; intracellular localization; protein conformation exocytosis, induced; cell growth, induced; cytoskeletal reorganization; signaling pathway regulation RAB3IP(INDUCES); RAB8A(INDUCES); Rhodopsin(INDUCES); SNAP-25(INDUCES); RAB11A(INDUCES); STX1A(INDUCES) 23471971; 30404838 2 1 0 SRc and insulin/IGF-1 dependent signaling pathway. Increase axonal growth in hippocampal neurons -ELAVL1 HuR RNA-binding Q15717 1994 19p13.2 human S242-p 5594500 NVPGNASsGWCIFIY molecular association, regulation; intracellular localization cell cycle regulation; cell growth, altered RNA(DISRUPTS) 18948743 2 0 0 ELAVL1 S242A mutation promotes interaction of the protein with cyclin A2 and cyclin B1 mRNA and cell proliferation -WEE1 Wee1 EC 2.7.10.2; KINASE; Kinase, protein; Protein kinase, Other; Protein kinase, Ser/Thr (non-receptor); Protein kinase, tyrosine (non-receptor) P30291 7465 11p15.4 human S642-p 455381 KKMNRSVsLTIY___ intracellular localization; enzymatic activity, inhibited; enzymatic activity, induced cell cycle regulation; cell growth, induced 14-3-3 theta(INDUCES) 15964826; 33796458; 34168048; 34570813 12 1 1 -MEF2D MEF2D DNA-binding; Transcription factor Q14814 4209 1q22 human S444-p 449407 SIKSEPVsPSRERSP sumoylation; molecular association, regulation; acetylation; intracellular localization; activity, inhibited neural plasticity; transcription, inhibited p300(DISRUPTS); HDAC5(INDUCES) DNA(DISRUPTS) 16356933; 30523159; 30699340; 37458356 7 19 26 -Ptpn6 SHP-1 EC 3.1.3.48; Motility/polarity/chemotaxis; PHOSPHATASE; Protein phosphatase, tyrosine (non-receptor) P29351 15170 6 F2|6 59.17 cM mouse Y536-p 448506 QKGQESEyGNITYPP molecular association, regulation; enzymatic activity, induced STAT5A(INDUCES) 17575265; 20858858; 22210881; 28811476 20 24 637 -PHB1 PHB Apoptosis; Cell cycle regulation; Chaperone; Mitochondrial; Motility/polarity/chemotaxis; Nuclear receptor co-regulator; Oncoprotein; Transcription, coactivator/corepressor P35232 5245 17q21.33 human Y114-p 6374001 FTSIGEDyDERVLPS Band_7 O-GlcNAc glycosylation; molecular association, regulation; phosphorylation cell differentiation, induced; transcription, altered SHP-1(INDUCES) 19238206; 19497338; 22124450 6 1 0 regulation of MAPK/ERK and PI3K/AKT signaling during adipogenesis, regulates phosphorylation of ERK, AKT and CREB; attenuates phosphorylation of Akt T308 and S473 -Map3k7 TAK1 iso3 EC 2.7.11.25; KINASE; Kinase, protein; Protein kinase, Ser/Thr (non-receptor); Protein kinase, TKL Q923A8 26409 4|4 A5 mouse T184-p 454876 GTACDIQtHMTNNKG PK_Tyr_Ser-Thr activity, induced; molecular association, regulation apoptosis, induced; signaling pathway regulation TAB2(INDUCES); TRAF6(INDUCES) 30626936 20 0 0 Phosphorylation of JNK, p38 and IkB (subsequent degradation) -Dync1i2 DYNC1I2 Microtubule-binding; Motility/polarity/chemotaxis; Motor Q62871 116659 3q22 rat S90-p 4033130 PPPMSPSsKSVSTPS molecular association, regulation; intracellular localization endocytosis, induced; cell motility, induced PXN(DISRUPTS); FAK(DISRUPTS); dynactin 1(DISRUPTS) 22553211 3 11 2 regulates focal adhesion turnover and stability; interaction between paxillin and DYNC1I2 facilitates endocytosis -RAB11A RAB11A G protein; G protein, monomeric; G protein, monomeric, Rab; Motility/polarity/chemotaxis P62491 8766 15q22.31 human S177-p 22826101 TEIYRIVsQKQMSDR activity, inhibited endocytosis, inhibited 22188018; 28696251 2 1 0 transient BK current AUC through Rab11A S177; S177D mutant led to retained transferrin in the endocytic recycling compartment -PRKDC DNAPK DNA repair, damage; EC 2.7.11.1; KINASE; Kinase, protein; Nucleolus; Protein kinase, Ser/Thr (non-receptor); Protein kinase, atypical P78527 5591 8q11.21 human S2624-p 473575 QTRTQEGsLSARWPV DNAPKcs_CC5 molecular association, regulation; protein conformation DNA repair, induced DNA(DISRUPTS) 24687855 2 6 0 cell survival induced, induces removal of cisplatin adducts from DNA, induces end processing -CTNNB1 CTNNB1 Actin-binding; Cell adhesion; Motility/polarity/chemotaxis; Nuclear receptor co-regulator; Oncoprotein; Transcription factor P35222 1499 3p22.1 human Y654-p 447585 RNEGVATyAAAVLFR activity, induced; protein stabilization; molecular association, regulation; intracellular localization cell growth, induced; transcription, induced; cytoskeletal reorganization; signaling pathway regulation; transcription, altered; cell growth, altered LEF-1(DISRUPTS); TBN(INDUCES); Src(INDUCES); CDH1(DISRUPTS); SMAD2(INDUCES); HIF1A(INDUCES); axin 1(DISRUPTS); CDH5(DISRUPTS); TCF4(INDUCES); Met(DISRUPTS) 12740122; 16952352; 17318191; 19104148; 20840866; 21423209; 23246962; 29311227; 34227224; 36064958; 37496925 32 2 20 -Snca SNCA Adaptor/scaffold O55042 20617 6 B3|6 29.15 cM mouse K6-ac 36294465 __MDVFMkGLSKAKE Synuclein molecular association, regulation; intracellular localization autophagy, induced; cytoskeletal reorganization SNCA(DISRUPTS) Other(DISRUPTS) 28257421 1 2 0 inhibits binding to lipid membranes -ERBB4 HER4 EC 2.7.10.1; KINASE; Kinase, protein; Membrane protein, integral; Protein kinase, TK; Protein kinase, tyrosine (receptor) Q15303 2066 2q34 human Y1162-p 2045347 RDKPKQEyLNPVEEN molecular association, regulation; enzymatic activity, induced cell motility, induced; cell growth, induced; apoptosis, inhibited GRB2(INDUCES); Arg(INDUCES); VAV2(INDUCES); VAV3(INDUCES) 16729043; 18721752; 19718025; 32561640 3 1 1 -GPHN gephyrin Adaptor/scaffold; EC 2.10.1.1; EC 2.7.7.75 Q9NQX3 10243 14q23.3-q24.1 human C212-pa 34668143 TEDKGVQcEEEEEEK molecular association, regulation; intracellular localization 25025157 1 1 0 clustering in neurons -Zfpm2 FOG2 C2H2-type zinc finger protein; Nuclear receptor co-regulator Q8CCH7 22762 15 B3.1|15 15.74 cM mouse K955-sm 1873213007 AAQLIATkEENKHLF molecular association, regulation transcription, induced GATA4(DISRUPTS) 23226341 1 0 0 desumoylation induces repression -Adcy6 ADCY6 Adenylyl cyclase; EC 4.6.1.1; Lyase; Membrane protein, integral; Membrane protein, multi-pass; Nucleotide Metabolism - purine; Transporter; Transporter, aquaporin family AAA40678 25289 7q36 rat S603-p 467270 WVPDRAFsRTKDSKA Adcy_cons_dom enzymatic activity, induced 11327830 1 0 0 -VDAC1 VDAC1 Channel, misc.; Membrane protein, integral; Mitochondrial P21796 7416 5q31.1 human S193-p 6406004 DGTEFGGsIYQKVNK Porin_3; TM protein conformation apoptosis, inhibited 19158487; 25545271 3 0 0 N-terminus conformation affected; S192A mutation results in cell death -CSF2RB CSF2RB Membrane protein, integral; Receptor, cytokine P32927 1439 22q12.3 human K477-ub 57676505 LRRKWEEkIPNPSKS protein degradation 24086733 1 0 0 -NANOG NANOG Cell development/differentiation; DNA-binding; Transcription factor Q9H9S0 79923 12p13.31 human T280-p 28070709 GLNVIQQtTRYFSTP protein stabilization; molecular association, regulation carcinogenesis, induced; cell motility, induced; cell growth, induced; transcription, induced p300(INDUCES); NANOG(INDUCES) DNA(INDUCES) 23708658 1 1 0 -FANCG FANCG DNA repair, damage O15287 2189 9p13.3 human S383-p 454239 DSSEPRFsPPPSPPG activity, induced 15367677 2 0 0 -OSBP2 OSBP2 Q969R2 23762 22q12.2 human S768-p 15721697 HSSPSSPsSDGKQKT Oxysterol_BP molecular association, regulation; protein conformation signaling pathway regulation Vimentin(INDUCES) 30925160 1 2 1 -NDUFV2 NDUFV2 EC 1.6.5.3; EC 1.6.99.3; Energy Metabolism - oxidative phosphorylation; Mitochondrial; Oxidoreductase P19404 4729 18p11.22 human Y193-p 25682900 VQINDNYyEDLTAKD 2Fe-2S_thioredx enzymatic activity, induced apoptosis, inhibited 22823520 1 0 0 -FPR1 FPR1 GPCR, family 1; Membrane protein, integral; Membrane protein, multi-pass; Motility/polarity/chemotaxis; Receptor, GPCR P21462 2357 19q13.41 human S338-p 450845 TSDTATNsTLPSAEV molecular association, regulation; receptor desensitization, altered; receptor internalization, altered ARRB2(INDUCES) 10514456; 16622009 2 0 0 -HELB helicase B DNA replication; EC 3.6.4.12; Helicase Q8NG08 92797 12q14.3|12q human S967-p 451682 APPADFPsPRKSSGD intracellular localization 15146062 1 27 13 -PHACTR3 PHACTR3 Protein phosphatase, regulatory subunit Q96KR7 116154 20q13.32-q13.33 human S318-p 18944907 QGRESKGsPKKRLDV intracellular localization neural plasticity; cytoskeletal reorganization 21487013 1 0 0 supports axonal elongation -NFE2 NF-E2 Cytoskeletal; DNA-binding; Transcription factor Q16621 4778 12q13.13 human K108-ub 11489908 NMAIPVSkPLSLSGL protein degradation; ubiquitination transcription, inhibited 19966288 1 0 0 -HAS2 HAS2 EC 2.4.1.212; Membrane protein, integral; Membrane protein, multi-pass; Motility/polarity/chemotaxis; Transferase Q92819 3037 8q24.13 human T110-p 18122801 LQSVKRLtYPGIKVV enzymatic activity, inhibited cell motility, altered; cell adhesion, altered 21228273 2 0 1 -SEPTIN7 SEPT7 Cell cycle regulation; Cytoskeletal; Hydrolase Q16181 989 7p14.2 human Y319-p 450712 RKLAAVTyNGVDNNK Septin molecular association, regulation SEPT11(DISRUPTS); SEPT8(INDUCES); SEPT9(DISRUPTS); SEPT6(DISRUPTS) 21767235 1 16 461 -Ghr GH receptor Membrane protein, integral; Receptor, cytokine P16310 25235 2q16 rat Y333-p 455507 ILGIHDNyKPDFYND GHBP molecular association, regulation; phosphorylation transcription, altered SOCS3(INDUCES) 10585430; 12766799 3 0 0 JAK2 phosphorylation -ZNF322 ZNF322A C2H2-type zinc finger protein; Transcription factor Q6U7Q0 79692 6p22.2 human S391-p 31086030 SEKGLELsPPHASEA protein degradation; ubiquitination transcription, inhibited 28581525 1 1 0 -NCOA3 SRC-3 ACETYLTRANSFERASE; Acetyltransferase; EC 2.3.1.48; Motility/polarity/chemotaxis; Nuclear receptor co-regulator; Transcription, coactivator/corepressor Q9Y6Q9 8202 20q13.12 human T1114-p 4252804 KAGLYGQtYPAQGPP protein stabilization; molecular association, regulation PSMA3(DISRUPTS) 18313384 1 0 0 some subset of these 8 residues -RACK1 RACK1 Adaptor/scaffold; G protein; G protein, heterotrimeric; G protein, heterotrimeric beta; Motility/polarity/chemotaxis; Nuclear receptor co-regulator P63244 10399 5q35.3 human K225-ub 12407451 LWDLNEGkHLYTLDG WD40 protein degradation carcinogenesis, induced 33323973 1 1 3 -PIM1 Pim1 iso2 EC 2.7.11.1; KINASE; Kinase, protein; Oncoprotein; Protein kinase, CAMK; Protein kinase, Ser/Thr (non-receptor) P11309-2 5292 6p21.2 human S65-p 1190526800 HSHSPRHsLRHSPGS protein stabilization; enzymatic activity, induced cell growth, induced; apoptosis, inhibited 30017192 1 0 0 -APTX APTX C2H2-type zinc finger protein; DNA repair, damage; EC 3.-.-.-; Nucleolus; Phosphatase (non-protein); RNA-binding Q7Z2E3 54840 9p21.1 human T125-p 9397200 AKNPGLEtHRKRKRS molecular association, regulation; intracellular localization apoptosis, altered KPNA1(DISRUPTS) 19561170 1 0 0 -Scnn1g ENaC-gamma Channel, sodium; Membrane protein, integral; Membrane protein, multi-pass; Transporter, ion channel P37091 24768 1q36 rat K10-ub 486252 PGEKIKAkIKKNLPV receptor recycling, inhibited; protein degradation; intracellular localization 9351815 1 0 0 -ACTR2 ARP2 Actin-binding; Cytoskeletal; Motility/polarity/chemotaxis P61160 10097 2p14 human Y202-p 38546300 KLLLLRGyAFNHSAD Actin cytoskeletal reorganization 25601402 1 0 0 EGF-increased actin filament assembly membrane protrusion, actin nucleation activity -HOXA10 HOXA10 DNA-binding; Transcription factor P31260 3206 7p15.2 human K164-sm 1873286912 CSFAQNIkEESSYCL protein degradation; molecular association, regulation; acetylation transcription, inhibited; cell adhesion, inhibited DNA(DISRUPTS) 29018572 1 0 0 Inhibits acetylation -SHC1 SHC1 Adaptor/scaffold; Apoptosis; Mitochondrial; Motility/polarity/chemotaxis P29353 6464 1q21.3 human S36-p 448508 TPPEELPsPSASSLG molecular association, regulation; intracellular localization; phosphorylation carcinogenesis, induced; apoptosis, induced MIA(DISRUPTS) 14749389; 15837797; 16794602; 17431427; 31941526 20 1 0 induces breast cancer cell survival, inhibits AMPK, SFK, AKT phosphorylation -TTK TTK Cancer Testis Antigen (CTA); EC 2.7.12.1; KINASE; Kinase, protein; Protein kinase, Other; Protein kinase, dual-specificity (non-receptor) P33981 7272 6q14.1 human S37-p 2846500 EDLTDELsLNKISAD intracellular localization; enzymatic activity, induced cell cycle regulation 25265012; 26119734; 36395767 8 9 0 autophosphorylation of this site is required for release TTK from kinetochore; causes decreased kinetochore localization of BubR1 and Mad2. -ABL1 Abl EC 2.7.10.2; KINASE; Kinase, protein; Oncoprotein; Protein kinase, TK; Protein kinase, tyrosine (non-receptor) P00519 25 9q34.12 human K711-ac 461004 EGGGSSSkRFLRSCS intracellular localization cell differentiation, induced 16648821 1 0 0 -PARP10 PARP10 EC 2.4.2.30; Nucleolus; Transferase Q53GL7 84875 8q24.3 human T601-p 31905435 EVRELLAtLEGLDLD enzymatic activity, inhibited carcinogenesis, induced; cell growth, induced 32060423 1 1 0 Induce HCC cell proliferation -XRCC4 XRCC4 DNA repair, damage Q13426 7518 5q14.2 human S328-p 3195419 LETLRNSsPEDLFDE XRCC4 ubiquitination; intracellular localization DNA repair, induced; DNA repair, inhibited DNA(INDUCES) 25166505; 26774286 3 10 1 recruitment to DNA damage sites; prevents Anaphase bridge formation, prevents chromosome instability -CSF2RB CSF2RB Membrane protein, integral; Receptor, cytokine P32927 1439 22q12.3 human K483-ub 57676504 EKIPNPSkSHLFQNG protein degradation 24086733 1 0 0 -Dusp1 DUSP1 EC 3.1.3.16; EC 3.1.3.48; Motility/polarity/chemotaxis; PHOSPHATASE; Protein phosphatase, dual-specificity P28563 19252 17 A3.3|17 13.28 cM mouse K57-ac 2884406 TIVRRRAkGAMGLEH Rhodanese molecular association, regulation signaling pathway regulation P38A(INDUCES) 18504304 1 0 0 inhibits phosphorylation of p38 and MAPK signaling -ETV1 ETV1 DNA-binding; Oncoprotein; Transcription factor P50549 2115 7p21.2 human S334-p 3059601 PTYQRRGsLQLWQFL molecular association, regulation transcription, induced DNA(DISRUPTS) 12213813; 25866208 2 1 0 -Cbx5 HP1 alpha Transcription, coactivator/corepressor Q61686 12419 15|15 F3 mouse S13-p 476164 KRTADSSsSEDEEEY molecular association, regulation H3(INDUCES) DNA(INDUCES) 21245376 1 34 2 important for chromosomal stability -HSP90AA1 HSP90A Chaperone; Heat shock protein P07900 3320 14q32.31 human Y313-p 465173 NEEYGEFyKSLTNDW HSP90 molecular association, regulation AHSA1(INDUCES) 22727666 1 2 8 -DPYSL3 CRMP-4 Hydrolase Q14195 1809 5q32 human S522-p 458800 PAGSARGsPTRPNPP cell motility, altered 16611631 5 52 7 increases axon length -Itpr2 IP3R2 Channel, calcium; Channel, ligand-gated; Membrane protein, integral; Membrane protein, multi-pass Q9Z329 16439 6 G3|6 77.7 cM mouse S937-p 468039 QMVLSRGsIFPVSVP activity, induced 19608738 1 7 0 -GTF2B GTF2B ACETYLTRANSFERASE; Acetyltransferase; Nuclear receptor co-regulator; Transcription factor Q00403 2959 1p22.2 human S65-p 13823200 DKATKDPsRVGDSQN molecular association, regulation transcription, induced CSTF2(INDUCES) 20226668 1 0 1 -Mef2c MEF2C DNA-binding; Transcription factor Q8CFN5 17260 13 C3|13 43.68 cM mouse S240-p 456976 NKNIQAKsPPPMNLG molecular association, regulation PIN1(INDUCES) 20801874 1 19 0 Pin1 binding decreases MEF2C stability and its transcriptional activity -CCR5 CCR5 GPCR, family 1; Membrane protein, integral; Membrane protein, multi-pass; Motility/polarity/chemotaxis; Receptor, GPCR; Receptor, cytokine P51681 1234 3p21.31 human S336-p 449901 QEAPERAsSVYTRST molecular association, regulation; receptor desensitization, altered; receptor internalization, altered; activity, inhibited ARRB1(INDUCES); ARRB2(INDUCES) 10085131; 11782464; 12065593 4 0 0 -Foxk2 FOXK2 DNA-binding; Transcription factor Q3UCQ1 68837 11|11 E2 mouse S190-p 36124957 HLISPLPsPTGTISA intracellular localization carcinogenesis, induced; transcription, altered 35412849 1 3 0 -NFATC1 NFAT2 DNA-binding; Transcription factor O95644 4772 18q23 human S257-p 40512526 SWLGARSsRPASPCN activity, induced carcinogenesis, induced; cell motility, induced; transcription, induced 31730483 5 3 0 multiple sites mutatnt -Spry4 SPRY4 Adaptor/scaffold; Inhibitor D3ZJA3 291610 18p11 rat Y53-p 454877 TSHVENDyIDNPSLA phosphorylation cell growth, inhibited; signaling pathway regulation 36818650 2 16 139 inhibits ERK phosphorylation, regulates Trk to Erk1/2 signaling pathway -PGK1 PGK1 Carbohydrate Metabolism - glycolysis and gluconeogenesis; EC 2.7.2.3; KINASE; Kinase, other P00558 5230 Xq21.1 human S203-p 468410 YFAKALEsPERPFLA PGK intracellular localization; protein conformation carcinogenesis, induced 26942675; 31578148 3 83 11 -NCOA3 SRC-3 ACETYLTRANSFERASE; Acetyltransferase; EC 2.3.1.48; Motility/polarity/chemotaxis; Nuclear receptor co-regulator; Transcription, coactivator/corepressor Q9Y6Q9 8202 20q13.12 human K786-sm 3817002 QEKDPKIkTETSEEG DUF4927 transcription, inhibited 16760465 1 1 0 -Gucy1b1 GUCY1B1 EC 4.6.1.2; Guanylyl cyclase; Lyase; Nucleotide Metabolism - purine; Receptor, misc. O54865 54195 3|3 E3 mouse Y192-p 469612 ESKEEDFyEDLDRFE molecular association, regulation; intracellular localization Fyn(INDUCES) 23602477 3 0 0 -HDAC1 HDAC1 DEACETYLASE; Deacetylase; EC 3.5.1.98; Hydrolase; Nuclear receptor co-regulator Q13547 3065 1p35.2-p35.1 human K444-sm 2407421 FKKAKRVkTEDEKEK cell cycle regulation; transcription, inhibited 11960997 3 1 0 -RELA NFkB-p65 DNA-binding; Nuclear receptor co-regulator; Transcription factor Q04206 5970 11q13.1 human K37-m1 12486801 RGMRFRYkCEGRSAG RHD_DNA_bind molecular association, regulation transcription, induced DNA(INDUCES) 19864627 1 0 0 -Esrp2 RBM35B RNA-binding Q8K0G8 77411 8|8 D3 mouse K534-ub 52473103 RCHKKMMkERYVEVV RRM_1 carcinogenesis, inhibited; RNA splicing, induced; cell growth, inhibited 26522722 1 0 0 -MED1 MED1 Nuclear receptor co-regulator; Transcription, coactivator/corepressor Q15648 5469 17q12 human T1032-p 458308 SSSNRPFtPPTSTGG activity, induced; molecular association, regulation; protein stabilization; receptor recycling, induced; intracellular localization carcinogenesis, induced; cell growth, induced; transcription, induced MED31(INDUCES) DNA(INDUCES) 16314496; 23850489; 35394046 4 8 2 -LAMTOR4 LAMTOR4 Q0VGL1 389541 7q22.1 human S67-p 1868827201 NVPFKRLsVVFGEHT molecular association, regulation LAMTOR1(DISRUPTS) 31314152 1 1 0 when in complex with HBXIP - dimer HBXIP-LAMTOR4 -AFP AFP Secreted; Secreted, signal peptide P02771 174 4q13.3 human K211-ac 1879738501 TKAATVTkELRESSL ubiquitination carcinogenesis, induced; cell motility, induced; cell growth, induced; apoptosis, inhibited 31811908 1 1 0 inhibits ubiquitination, promotes the migration and invasion -MAPKAP1 Sin1 Adaptor/scaffold Q9BPZ7 79109 9q33.3 human T86-p 3253548 GIRRRSNtAQRLERL SIN1 activity, induced 26235620 3 4 10 -Rab7a Rab7 G protein; G protein, monomeric; G protein, monomeric, Rab P51150 19349 6 D1|6 39.13 cM mouse S72-p 468547 AGQERFQsLGVAFYR Ras molecular association, regulation; intracellular localization CHML(DISRUPTS); CHM(DISRUPTS); RILP(DISRUPTS) 26038114 7 50 21 endo-lysosomal localization S72A mutant, S72D or S72E mutant were diffusely localized -UBR5 UBR5 EC 6.3.2.-; EC 6.3.2.19; Ligase; Nuclear receptor co-regulator; UBIQUITIN LIGASE; Ubiquitin conjugating system; Ubiquitin ligase O95071 51366 8q22.3 human S1227-p 21214703 DCKLKRTsPTAYCDC translation, inhibited 28559278 1 4 0 translational repression of TRAF3 mRNA -H4C1 H4 DNA-binding P62805 8359 6p22.2 human K12-ac 459013 KGGKGLGkGGAKRHR molecular association, regulation; methylation cell cycle regulation; carcinogenesis, induced; cell growth, inhibited; apoptosis, induced; transcription, induced; transcription, altered; DNA repair, induced; chromatin organization, altered; cell differentiation, induced TBN(INDUCES); polybromo 1(INDUCES); BRDT(INDUCES); CGI-09(INDUCES); BRD7(INDUCES); PUS1(INDUCES); THOC4(INDUCES); SETD8(DISRUPTS); TAF4(INDUCES); BRD2(INDUCES) DNA(INDUCES); DNA(DISRUPTS) 11387442; 15456746; 17498659; 17530637; 17560255; 18179771; 18418072; 18628788; 18985155; 20043883; 20048151; 20368734; 20709061; 20720004; 21047799; 21726812; 23287868; 23653357; 23970329; 25788266; 25806092; 36961817 93 25 531 estrogen induced transcription; decline of histone marks was more notable in H4K5ac and H4K12ac; aberrant histone acetylation and chromatin compaction in sperm of subfertile men -Ksr1 KSR KINASE; Kinase, protein; Protein kinase, Ser/Thr (non-receptor); Protein kinase, TKL Q61097 16706 11 B5|11 46.74 cM mouse Y552-p 22639616 KASQTSVyLQEWDIP phosphorylation 23993095 1 0 0 induces phosphorylation of ERK -NACA NACA Motility/polarity/chemotaxis; Transcription, coactivator/corepressor E9PAV3 4666 12q13.3 human S1906-p 454238 PELEEQDsTQATTQQ activity, induced; intracellular localization transcription, induced 15299025 2 1 0 -Shc1 SHC1 Adaptor/scaffold; Apoptosis; Mitochondrial; Motility/polarity/chemotaxis P98083 20416 3 F1|3 39.11 cM mouse S139-p 448791 EEWTRHGsFVNKPTR molecular association, regulation PTP-PEST(INDUCES) 12052829 4 35 16 binding to PTPN12 down-regulates insulin-induced ERK activation -OPA1 OPA1 Apoptosis; EC 3.6.5.5; Hydrolase; Membrane protein, integral; Mitochondrial O60313 4976 3q29 human K931-ac 31068001 KIKLLTGkRVQLAED OPA1_C enzymatic activity, inhibited; activity, inhibited 24344202; 33857259 2 2 0 acetyl-mimic at K931, which inhibits OPA1 functionK931, which inhibits OPA1 function, allows for mitochondrial fragmentation and virus production.; regulation of mitochondrial dynamics, morphology and function -Cdkn1a p21Cip1 Cell cycle regulation; Inhibitor Q64315 114851 rat T145-p 447837 QGRKRRQtSLTDFYH cell cycle regulation; carcinogenesis, induced 34569407 20 0 0 -Kcnj3 GIRK1 Channel, potassium; Membrane protein, integral; Membrane protein, multi-pass P63251 50599 3q21 rat S185-p 450683 GCMFIKMsQPKKRAE IRK activity, inhibited 14732702 1 0 0 inhibition of channel open-state probability -Ppargc1a PGC-1 alpha Nuclear receptor co-regulator; Transcription, coactivator/corepressor O70343 19017 5|5 C1 mouse S572-p 6421246 RSRSRSFsRHRSCSR molecular association, regulation; activity, inhibited transcription, inhibited; signaling pathway regulation HNF4 alpha(DISRUPTS) 21646374 1 0 0 Gluconeogenic pathway; Regulation of gluconeogenesis -PRKACA PKACA EC 2.7.11.11; KINASE; Kinase, protein; Protein kinase, AGC; Protein kinase, Ser/Thr (non-receptor) P17612 5566 19p13.12 human S339-p 449886 EEEEIRVsINEKCGK protein stabilization; protein processing; protein conformation; phosphorylation; enzymatic activity, induced 15481030; 22154087; 22493239 13 36 28 optimal enzymatic activity; solublity of C-sub unit, phosphorylation of T198 site -Tp53 p53 Activator; DNA-binding; Motility/polarity/chemotaxis; Nuclear receptor co-regulator; Transcription factor; Tumor suppressor P10361 24842 10q24 rat S390-p 447535 IKKVGPDsD______ apoptosis, induced 35917315 118 15 0 -CDC25B CDC25B EC 3.1.3.48; Motility/polarity/chemotaxis; Nuclear receptor co-regulator; PHOSPHATASE; Protein phosphatase, dual-specificity P30305 994 20p13 human S50-p 20503402 PVRAAASsPVTTLTQ phosphorylation 21640712 1 3 0 induces phosphorylation at other sites by PLK1 -Aqp2 AQP2 Channel, misc.; Membrane protein, integral; Membrane protein, multi-pass; Transporter; Transporter, aquaporin family P56402 11827 15 F1|15 56.13 cM mouse S261-p 464644 RQSVELHsPQSLPRG ubiquitination; intracellular localization 19966308; 29212817 38 9 0 -Nlrp3 NLRP3 Inhibitor Q8R4B8 216799 11|11 B1.3 mouse S330-p 409465602 RGDILLSsLIRKKLL NACHT phosphorylation transcription, induced; signaling pathway regulation 33087357 2 1 0 regulation of AKT-STAT1 phosphorylation and AKT-STAT1-PRDX1-NF-kB signaling during inflammation -MAVS MAVS Adaptor/scaffold; Membrane protein, integral Q7Z434 57506 20p13 human R41-me 1883504204 LTARDQDrLRATCTL activity, inhibited 36028484 1 1 0 PRMT9-mediated MAVS methylation inhibits MAVS aggregation and activation. -ELK4 ELK4 DNA-binding; Transcription, coactivator/corepressor P28324 2005 1q32.1 human T194-p 41290001 SVIKFVTtPSKKPPV cell growth, induced; transcription, induced 26028036 1 1 0 -ESCO2 ESCO2 ACETYLTRANSFERASE; Acetyltransferase; DNA replication; EC 2.3.1.- Q56NI9 157570 8p21.1 human T233-p 1881957104 NEPSLGRtQKSKSEV molecular association, regulation; intracellular localization carcinogenesis, induced; DNA repair, induced MDC1(INDUCES) 37377435 1 0 0 -TPX2 TPX2 Cell cycle regulation; Microtubule-binding Q9ULW0 22974 20q11.21 human S121-p 459996 PAQPQRRsLRLSAQK molecular association, regulation cell cycle regulation CLASP1(INDUCES) 26240182 3 17 33 required for normal spindle length -IL9R IL9R Membrane protein, integral; Receptor, cytokine Q01113 3581 Xq28 and Yq12 human Y407-p 10306403 WRVQTLAyLPQEDWA apoptosis, inhibited; cell growth, altered DNA(INDUCES) 8756628 1 0 0 required for IL9-induced binding to GRR oligonucleotide complex containing activated STAT1-alpha, STAT3 and STAT5. -Csf1r CSFR EC 2.7.10.1; KINASE; Kinase, protein; Membrane protein, integral; Oncoprotein; Protein kinase, TK; Protein kinase, tyrosine (receptor) P09581 12978 18 E1|18 34.41 cM mouse Y807-p 448365 DIMNDSNyVVKGNAR PK_Tyr_Ser-Thr molecular association, regulation; enzymatic activity, induced cell cycle regulation; apoptosis, altered; cell differentiation, altered; apoptosis, inhibited; transcription, induced; transcription, altered; cell growth, altered PLCG1(INDUCES) 10727433; 11739737; 1652061; 17420255; 18519746; 7545432; 8981370; 9312046 21 2 12 -TAB1 TAB1 Activator; Motility/polarity/chemotaxis Q15750 10454 22q13.1 human S453-p 22869803 TNTHTQSsSSSSDGG intracellular localization; phosphorylation; enzymatic activity, induced transcription, inhibited 22216226 1 0 0 TAB1 induce p38 MAPK phosphorylation and mRNA destabilization, induces p38 MAPK activation. TAB1 and p38MAPK mutually control eachother's phosphorylation status, activity and intracellular localization. -MALT1 MALT1 Adaptor/scaffold; Apoptosis; EC 3.4.22.-; Ligase; Nuclear export; Protease; UBIQUITIN LIGASE; Ubiquitin conjugating system Q9UDY8 10892 18q21.32 human K644-ub 2134705 LDLDIDPkDANKGTP MALT1_Ig protein degradation; protein stabilization; molecular association, regulation; protein processing; protein conformation; enzymatic activity, induced carcinogenesis, induced; cell growth, induced; transcription, induced IKKA(INDUCES); MALT1(INDUCES) 17948050; 23416615; 28052131; 31980531 4 1 0 MALT1 auto-cleavage at R149, MALT1 oligomerization; conformational changes in the loop connecting K644 to Y657 and the active site; size exclusion chromatography, induces NF-kB, IL-2 activation; activation of NF-kB pathway and IL-2 induction; monomeric ubiquitin binds to the Ig3 domain, transcription and secretion of IL-2 -PML PML Nucleolus; Oncoprotein; SUMO LIGASE; SUMO conjugating system; SUMO ligase; Transcription factor; Tumor suppressor; Ubiquitin conjugating system P29590 5371 15q24.1 human S518-p 465867 PSTSKAVsPPHLDGP DUF3583 protein degradation; molecular association, regulation; ubiquitination; phosphorylation carcinogenesis, induced; carcinogenesis, inhibited; cell growth, induced; cell motility, induced; apoptosis, inhibited; transcription, induced; signaling pathway regulation C/EBP-epsilon(INDUCES); PIN1(INDUCES); KLHL20(INDUCES) 17989716; 21840486; 25293974 3 61 25 induces S6K phosphorylation and hence mTOR/HIF signaling pathway; induces GLUT1 expression, induces HIF1 signaling and tumor hypoxia -G6PC1 G6PC1 Carbohydrate Metabolism - galactose; Carbohydrate Metabolism - glycolysis and gluconeogenesis; Carbohydrate Metabolism - starch and sucrose; EC 3.1.3.9; Endoplasmic reticulum; Membrane protein, integral; Membrane protein, multi-pass; Phosphatase (non-protein); Transporter; Transporter, SLC family P35575 2538 17q21.31 human H176-p 10296600 SRIYLAAhFPHQVVA PAP2 intracellular localization; enzymatic activity, induced 14718531; 9497333 3 0 0 phosphate acceptor in Glc-6-Pase-Beta, phosphoryl enzyme intermediate during Glc-6-P hydrolysis; phosphoryl acceptor, essential for G6Pase activity -TARDBP TDP-43 RNA-binding Q13148 23435 1p36.22 human K136-ac 9912116 EVLMVQVkKDLKTGH RRM_1 molecular association, regulation; intracellular localization RNA splicing, induced 35264561 1 0 1 K136 shows a nuclear droplet-like localization and reduced solubility and aggregation, and induces ubiquitylation and pathological phosphorylation, K136 mutant looses RNA binding and splicing activity. -MAX MAX DNA-binding; Transcription factor P61244 4149 14q23.3 human K66-ac 474517 SRAQILDkATEYIQY HLH molecular association, regulation; intracellular localization transcription, induced B-Myc(INDUCES) DNA(DISRUPTS) 17217336 1 2 0 -GFAP GFAP Cytoskeletal F1RR02 396562 pig T7-p 449617 _MERRRVtSAARRSY Filament_head cell cycle regulation 1379174 6 0 0 -SUV39H1 SUV39H1 Amino Acid Metabolism - lysine degradation; EC 2.1.1.43; METHYLTRANSFERASE; Methyltransferase; Methyltransferase, protein lysine O43463 6839 Xp11.23 human Y308-p 1871199002 LDYVEDVyTVDAAYY SET methylation; enzymatic activity, induced signaling pathway regulation 30833073 1 0 0 NRG-1/ErbB4 signaling -SEC63 SEC63 Endoplasmic reticulum; Membrane protein, integral; Membrane protein, multi-pass Q9UGP8 11231 6q21 human S574-p 27440601 EEVSDKGsDSEEEET molecular association, regulation SEC62(INDUCES) 23287549 1 1 0 -DLG1 DLG1 Adaptor/scaffold; Motility/polarity/chemotaxis Q12959 1739 3q29 human T657-p 22496705 KERARLKtVKFNSKT cell motility, induced 22027822 1 0 0 -GLI1 GLI1 C2H2-type zinc finger protein; Oncoprotein; Transcription factor P08151 2735 12q13.3 human S130-p 1877717204 HLSIGTMsPSLGFPA activity, induced; molecular association, regulation transcription, induced SUFU(DISRUPTS) 35831023 1 0 0 -INPPL1 SHIP-2 Carbohydrate Metabolism - inositol phosphate; EC 3.1.3.86; Motility/polarity/chemotaxis; Phosphatase, lipid O15357 3636 11q13.4 human K315-ub 12718515 PVQAFEVkLDVTLGD intracellular localization; enzymatic activity, induced 19880507 1 1 0 -CAD CAD Amino Acid Metabolism - alanine, aspartate and glutamate; EC 2.1.3.2; EC 3.5.2.3; EC 6.3.5.5; Hydrolase; KINASE; Ligase; Nucleotide Metabolism - pyrimidine; Transferase P27708 790 2p23.3 human T456-p 451248 KVYFLPItPHYVTQV activity, induced; intracellular localization; enzymatic activity, induced carcinogenesis, inhibited; cell growth, induced 15890648; 25472841; 31391321; 33771897 10 1 0 -ATXN3 ataxin-3 DEUBIQUITINASE; DNA repair, damage; EC 3.4.19.12; Protease; Transcription regulation; Ubiquitin-specific protease P54252 4287 14q32.12 human S256-p 479405 LRRAIQLsMQGSSRN UIM molecular association, regulation 17434145 2 1 0 ; phosphorylation of this site prevents protein aggregation; excessive aggregation of mutant S256A is inhibited by Hsp70 -BAIAP2 IRSp53 Actin-binding; Motility/polarity/chemotaxis Q9UQB8 10458 17q25.3 human S366-p 468035 KTLPRSSsMAAGLER molecular association, regulation cytoskeletal reorganization 14-3-3 theta(INDUCES) 21282462 2 44 26 regulates cell spreading -Irak2 IRAK2 KINASE; Kinase, protein; Protein kinase, Ser/Thr (non-receptor); Protein kinase, TKL Q8CFA1 108960 6 E3|6 52.82 cM mouse S136-p 18262493 VRPVKPRsLLDTGPI molecular association, regulation; intracellular localization signaling pathway regulation PHB(INDUCES); OPA1(INDUCES); TIMM50(INDUCES) 32778760 1 2 0 IL-1R?MyD88?IRAK2?PHB/OPA1 signaling pathway -EZH2 EZH2 EC 2.1.1.43; METHYLTRANSFERASE; Methyltransferase; Methyltransferase, protein lysine Q15910 2146 7q36.1 human S363-p 466986 GRLPNNSsRPSTPTI cell growth, inhibited; cell motility, inhibited 27494834 1 11 30 decreases H3K27 trimethylation -Gem GEM G protein; G protein, monomeric; G protein, monomeric, RGK P55041 14579 4 A1|4 5.34 cM mouse S286-p 1211200 NMAFKLKsKSCHDLS molecular association, regulation; intracellular localization 14-3-3 beta(DISRUPTS) 17605760 2 2 0 -PREX1 PREX1 GEF; GEF, Rac/Rho Q8TCU6 57580 20q13.13 human S436-p 2526571 KDRRRKLsTVPKCFL DEP molecular association, regulation; protein conformation; activity, inhibited 26797121; 32661198 2 4 2 regulates PREX1 binding to negatively charged phospholipids; inhibits GEF activity -Etv4 ETV4 DNA-binding P28322 18612 11 D|11 65.48 cM mouse K261-sm 3144815 PGAGVVIkQERTDFA ETS_PEA3_N protein degradation; ubiquitination transcription, induced; transcription, inhibited 18447755; 19307308 4 1 0 -APP APP Apoptosis; Cell surface; Membrane protein, integral; Receptor, misc.; Transcription factor P05067 351 21q21.3 human K687-ac 1876853302 GYEVHHQkLVFFAED Beta-APP molecular association, regulation 32207962 1 0 0 K887 Ac peptide reduces fibrillization of APP affects toxicity. It aggregates with the KKAc and shows higher toxicity than WT or K699 -PLD2 PLD2 EC 3.1.4.4; Lipid Metabolism - ether lipid; Lipid Metabolism - glycerophospholipid; Motility/polarity/chemotaxis; Phospholipase O14939 5338 17p13.2 human T566-p 15343400 FIQRWNFtKTTKAKY intracellular localization cytoskeletal reorganization 20733000 1 0 0 required for integrin-mediated cell spreading -Stx1a STX1A Membrane protein, integral; Vesicle P32851 116470 12q12 rat T21-p 451260 SDDDDDVtVTVDRDR endocytosis, altered; exocytosis, induced 33582301 2 1 0 -Mapt Tau ACETYLTRANSFERASE; Acetyltransferase; Cytoskeletal P10637 17762 11 67.79 cM|11 E1 mouse S491-p 447927 GERSGYSsPGSPGTP intracellular localization neural plasticity 24653715; 34453977 91 33 33 -MUS81 MUS81 Deoxyribonuclease; EC 3.1.22.-; Nucleolus Q96NY9 80198 11q13.1 human S87-p 31880574 RLQRHRTsGGDHAPD molecular association, regulation cell cycle regulation; DNA repair, altered SLX4(INDUCES) 29850896; 31114910; 37254810 3 1 0 -DEPTOR DEPTOR Apoptosis Q8TB45 64798 8q24.12 human S282-p 4723838 AVRRSSMsSCGSSGY protein degradation; molecular association, regulation carcinogenesis, induced; apoptosis, inhibited; signaling pathway regulation mTOR(DISRUPTS) 19446321 1 3 2 PI3K-Akt signaling -HSF1 HSF1 DNA-binding; Transcription factor Q00613 3297 8q24.3 human S326-p 455484 SSVDTLLsPTALIDS Vert_HS_TF activity, induced; molecular association, regulation; protein stabilization; intracellular localization; protein conformation; enzymatic activity, induced; phosphorylation cell cycle regulation; carcinogenesis, induced; carcinogenesis, altered; cell motility, induced; transcription, induced; signaling pathway regulation; transcription, altered; translation, altered; cell differentiation, induced; cell growth, induced; apoptosis, inhibited; cytoskeletal reorganization; translation, induced; transcription, inhibited CDK9(INDUCES); GTF2B(INDUCES); PIN1(INDUCES); SGOL2(INDUCES) RNA(INDUCES) 15760475; 22496356; 22768106; 24126052; 24469056; 24516381; 24746225; 24954509; 25679764; 25752395; 25963659; 26010766; 27354066; 27791982; 28415561; 28618124; 29088759; 30138434; 31614463; 31657478; 32959058; 33268814; 33407730; 33461973; 34922589; 35080342; 35201262; 35959699 48 25 13 -ARHGAP33 SNX26 GAP; GAP, Rac/Rho; Vesicle O14559 115703 19q13.12 human Y1169-p 476790 PTPPEPLyVNLALGP molecular association, regulation; phosphorylation cell growth, induced; cell differentiation, induced; transcription, induced; signaling pathway regulation SHP-2(INDUCES) 17664338 1 3 69 ERK5 MAP kinase pathway regulation,Cdc42/PAK signaling pathway, regulates phosphorylation of ERK5 and PAK -Brsk2 BRSK2 EC 2.7.11.1; EC 2.7.11.26; KINASE; Kinase, protein; Protein kinase, CAMK; Protein kinase, Ser/Thr (non-receptor) Q69Z98 75770 7|7 F5 mouse S440-p 4734885 PHPSPRGsPLPTPKG protein stabilization; enzymatic activity, inhibited; phosphorylation 23790753 1 4 1 inhibits axon branching (activated in BRSK2 18A mutant) -Hist1h2ail1 H3 DNA-binding Q6LED0 291159 17p11 rat K9-m2 459006 RTKQTARkSTGGKAP Histone transcription, inhibited 19476549 119 21 0 -ANKRD2 ANKRD2 Contractile Q9GZV1 26287 10q24.2 human S99-p 480101 QERVRKTsLDLRREI intracellular localization 28615162 2 6 8 91% of the pANKRD2 Ser99 was found in the Cyt fraction -CAV2 caveolin-2 Adaptor/scaffold; Motility/polarity/chemotaxis P51636 858 7q31.2 human S23-p 460671 DDSYSHHsGLEYADP Caveolin activity, induced 12743374 4 26 84 formation of caveolae -CEBPB C/EBP-beta DNA-binding; Motility/polarity/chemotaxis; Transcription factor P17676 1051 20q13.13 human K265-ac 458940 QVKSKAKkTVDKHSD molecular association, regulation transcription, inhibited DNA(DISRUPTS) 12574125 4 1 0 -MCL1 MCL1 Apoptosis; Channel, misc.; Inhibitor; Membrane protein, integral; Mitochondrial Q07820 4170 1q21.2 human T70-p 31857746 ASPPSTLtPDSRRVA protein degradation; protein stabilization; ubiquitination apoptosis, induced 27166195; 27738316 2 0 0 -STK39 STLK3 EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, STE; Protein kinase, Ser/Thr (non-receptor) Q9UEW8 27347 2q24.3 human S371-p 456506 VRRVPGSsGHLHKTE enzymatic activity, induced signaling pathway regulation 18270262; 21733846 20 20 1 -PTPRA PTPRA iso6 EC 3.1.3.48; Membrane protein, integral; Motility/polarity/chemotaxis; PHOSPHATASE; Receptor protein phosphatase, tyrosine P18433-2 5786 20p13 human Y789-p 447613 YIDAFSDyANFK___ molecular association, regulation; enzymatic activity, induced GRB2(INDUCES); Src(INDUCES) 10698938; 11689444; 8670803 17 85 2339 -Sipa1l1 SIPA1L1 GAP; GAP, Ras Q8C0T5 217692 12|12 D1 mouse S1328-p 3595500 SLGASTSsPRSGPGK protein degradation; molecular association, regulation PLK2(INDUCES) 18498738 1 2 0 -MAP3K2 MEKK2 EC 2.7.11.25; KINASE; Kinase, protein; Protein kinase, STE; Protein kinase, Ser/Thr (non-receptor) Q9Y2U5 10746 2q14.3 human K260-me 35480417 PIFEKFGkGGTYPRR molecular association, regulation; phosphorylation carcinogenesis, induced; cell growth, induced; signaling pathway regulation PPP2R2A(DISRUPTS) 24847881 1 0 0 induces MEK/ERK phosphorylation, Ras/Raf/MEK/ERK signaling pathway -Gabrb3 GABRB3 Channel, chloride; Channel, ligand-gated; Membrane protein, integral; Membrane protein, multi-pass; Transporter; Transporter, ion channel P63080 14402 7 B5|7 33.53 cM mouse S406-p 486453 GIQYRKQsMPKEGHG Neur_chan_memb activity, induced 17442679; 22531784 3 1 0 potentiated GABA currents; rapid insertion of GABA receptors at the cell surface and enhanced tonic current -Themis2 THEMIS2 Adaptor/scaffold; Cell adhesion; Motility/polarity/chemotaxis Q91YX0 230787 4|4 D2.3 mouse Y660-p 9415036 PDMDDHDyEEI____ molecular association, regulation LYN(INDUCES); GRB2(INDUCES) 20644716 1 2 21 promotes LPS-induced TNF production -Clec7a dectin-1 Membrane protein, integral Q6QLQ4 56644 6|6 F3 mouse Y3-p 50346900 _____MKyHSHIENL molecular association, regulation SHIP(INDUCES) 26416276 1 1 0 -Dll1 DLL1 Cell development/differentiation; Membrane protein, integral; Motility/polarity/chemotaxis Q61483 13388 17 A2|17 8.95 cM mouse S696-p 31012805 KRPESVYsTSKDTKY transcription, induced 24449764 1 1 0 mutant shows increased stability -APP APP Apoptosis; Cell surface; Membrane protein, integral; Receptor, misc.; Transcription factor P05067 351 21q21.3 human S697-p 54165901 FFAEDVGsNKGAIIG Beta-APP protein conformation 26898910 2 0 0 forms oligomers without fibril formation, intraneuronal deposition, increased toxicity in human neurons -NUMB NUMB Cell development/differentiation P49757 8650 14q24.2-q24.3 human T102-p 3333403 LRVVDEKtKDLIVDQ PID activity, induced; intracellular localization endocytosis, altered 18657069 1 0 0 -Opn4 melanopsin GPCR, family 1; Membrane protein, integral; Membrane protein, multi-pass; Receptor, GPCR Q9QXZ9 30044 14|14 B mouse S381-p 36745800 QRSHPSLsYRSTHRS protein conformation; activity, inhibited 27181062; 32236094 3 1 0 -Wnk4 WNK4 EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, Other; Protein kinase, Ser/Thr (non-receptor) Q80UE6 69847 11|11 D mouse K1136-ub 40323314 EALQTLQkKEIEDLY protein degradation 23576762 1 1 0 regulates electrolyte homeostasis and involved in Pseudohypoaldosteronism type II (PHAII) pathogenesis -CUX1 CUTL1 DNA-binding; Membrane protein, integral; Transcription factor P39880 1523 7q22.1 human S1237-p 456479 TEYSQGAsPQPQHQL transcription, inhibited 16574653 2 8 4 -DNM1L DRP1 Apoptosis; EC 3.6.5.5; Endoplasmic reticulum; Hydrolase; Microtubule-binding; Mitochondrial; Motor O00429 10059 12p11.21 human S693-p 27276100 LVGQLYKsSLLDDLL GED enzymatic activity, inhibited apoptosis, inhibited 23185298 1 0 0 mitochondrial elongation -CRHR1 CRF-R1 iso2 GPCR, family 2; Membrane protein, integral; Membrane protein, multi-pass; Receptor, GPCR P34998-2 1394 17q21.31 human T399-p 454252 ARAMSIPtSPTRVSF receptor desensitization, altered 15498832 1 0 0 -TP53 p53 Activator; DNA-binding; Motility/polarity/chemotaxis; Nuclear receptor co-regulator; Transcription factor; Tumor suppressor P04637 7157 17p13.1 human K370-m3 2574936 RAHSSHLkSKKGQST molecular association, regulation JMJD2A(INDUCES) 19334741 1 1 0 strongest interaction with K370me3 -Fos Fos DNA-binding; Motility/polarity/chemotaxis; Oncoprotein; Transcription factor P01101 14281 12 D2|12 39.7 cM mouse S374-p 448482 PSSDSLSsPTLLAL_ carcinogenesis, induced; cell differentiation, induced; signaling pathway regulation 21119595 12 3 0 -Drgx DRGX DNA-binding Q8BYH0 107751 14|14 B mouse S231-p 62925705 ANLLPSTsSSPGPAS transcription, altered 28049756 1 1 0 -Cacna1b CACNA1B Channel, calcium; Membrane protein, integral; Membrane protein, multi-pass Q02294 257648 3p13 rat T422-p 465546 AVLKRAAtKKSRNDL activity, induced 16704976; 17294162; 19167461 4 0 0 -FLT1 VEGFR1 EC 2.7.10.1; KINASE; Kinase, protein; Membrane protein, integral; Protein kinase, TK; Protein kinase, tyrosine (receptor) P17948 2321 13q12.3 human Y1333-p 448212 DYNSVVLySTPPI__ protein degradation; molecular association, regulation; receptor internalization, altered cell cycle regulation; signaling pathway regulation; cell growth, altered PLCG1(INDUCES); NCK1(INDUCES); CBL(INDUCES); CRK(INDUCES) 11583921; 15001553; 25119572; 9722576 4 0 0 -Kcnb1 Kv2.1 Channel, cation; Channel, ligand-gated; Channel, potassium; Membrane protein, integral; Membrane protein, multi-pass P15387 25736 3q42 rat Y128-p 449085 YWGIDEIyLESCCQA BTB_2 activity, induced; molecular association, regulation; intracellular localization apoptosis, induced; signaling pathway regulation CAMK2A(INDUCES); STX1B(INDUCES); PTPRE(INDUCES) 12615930; 22106938; 23918396 7 0 0 -MRE11 MRE11A Cell cycle regulation; DNA repair, damage; DNA-binding; Deoxyribonuclease P49959 4361 11q21 human R572-me 2344809 ATNKGRGrGRGRRGG intracellular localization 15970667 1 0 0 localizes in nucleus and associates with nuclear bodies and sites of DNA damage -S1PR1 EDG-1 GPCR, family 1; Membrane protein, integral; Membrane protein, multi-pass; Receptor, GPCR P21453 1901 1p21.2 human T236-p 447691 RTRSRRLtFRKNISK 7tm_1 cell motility, altered; cytoskeletal reorganization 11583630 2 1 0 Cortical actin assembly, chemotaxis, and angiogenesis -CTBP1 CTBP1 Cell cycle regulation; EC 1.1.1.-; Nuclear receptor co-regulator; Oxidoreductase; Transcription, coactivator/corepressor Q13363 1487 4p16.3 human K428-sm 2407413 PSPGQTVkPEADRDH molecular association, regulation; intracellular localization transcription, inhibited nNOS(DISRUPTS) 12769861 2 0 0 -DNAJB1 HSP40 Chaperone; Nucleolus P25685 3337 19p13.12 human S149-p 30306601 TNVNFGRsRSAQEPA transcription, inhibited 24309468 1 0 0 -ETV4 ETV4 DNA-binding P43268 2118 17q21.31 human K226-sm 3144819 PYPQQSFkQEYHDPL ETS_PEA3_N transcription, inhibited 17585876 4 1 0 -Bcr Bcr EC 2.7.11.1; GAP; GAP, Rac/Rho; GEF, Rac/Rho; KINASE; Kinase, protein; Oncoprotein; Protein kinase, Ser/Thr (non-receptor); Protein kinase, atypical Q6PAJ1 110279 10 C1|10 38.49 cM mouse Y362-p 447796 VSPSPTTyRMFRDKS enzymatic activity, inhibited cell growth, altered 17934518 4 1 29 -IKBKB IKKB EC 2.7.11.10; KINASE; Kinase, protein; Protein kinase, Other; Protein kinase, Ser/Thr (non-receptor) O14920 3551 8p11.21 human S177-p 447492 AKELDQGsLCTSFVG Pkinase molecular association, regulation; ubiquitination; intracellular localization; phosphorylation; enzymatic activity, induced carcinogenesis, induced; cell growth, induced; transcription, induced; transcription, inhibited; signaling pathway regulation IKKA(INDUCES) 10195894; 11325957; 11460167; 16267042; 18930133; 23123196; 24833394; 34017102; 35173553; 35339487; 35525271; 9346484 43 1 0 TRIM26 enhances TLRs-induced NF-kB and MAPK signaling.; induces IKB phosphorylation; regulates NFkB signaling; induces induces nuclear localization of p65, thus inducing the TNFa/NF-kB signaling pathway; PKM2 expression -EDNRA EDNRA GPCR, family 1; Membrane protein, integral; Membrane protein, multi-pass; Motility/polarity/chemotaxis; Receptor, GPCR P25101 1909 4q31.22-q31.23 human S404-p 2911711 SVPMNGTsIQWKNHD receptor desensitization, induced 24064210 1 2 0 Lack of S397, T403 and S404 influences desensitization to a greater extent compared than S391, S393, and T396 -BLVRA BVR Cofactor and Vitamin Metabolism - porphyrin and chlorophyll; EC 1.3.1.24; KINASE; Kinase, protein; Oxidoreductase; Protein kinase, Ser/Thr (non-receptor) P53004 644 7p13 human S149-p 486325 GKDLLKGsLLFTAGP Biliv-reduc_cat phosphorylation transcription, induced 17639074 1 3 0 induces phosphorylation of PKCZ -WDR62 WDR62 Adaptor/scaffold O43379 284403 19q13.12 human S32-p 10989988 VPARRGQsSPPPAPP cell cycle regulation 25501809; 26713495 2 11 8 WDR62 regulation of the mitotic spindle; microtubule association -GATA1 GATA1 DNA-binding; Transcription factor P15976 2623 Xp11.23 human S187-p 451237 LNSAAYSsPKLRGTL molecular association, regulation carcinogenesis, induced; cell motility, induced HDAC3(INDUCES); HDAC4(INDUCES) 25726523 3 0 0 GATA1-HDAC3/4 complex induces EMT of breast cancer cells, inhibits E-cadherin and promotes fibronectin expression -Setdb1 SETDB1 Amino Acid Metabolism - lysine degradation; EC 2.1.1.43; METHYLTRANSFERASE; Methyltransferase; Methyltransferase, protein lysine O88974 84505 3|3 F2.1 mouse K884-ub 56394103 IESVENFkEGYESDV SET intracellular localization; enzymatic activity, induced cell differentiation, inhibited 33971063 3 3 0 K885A mutant of SETDB1 inhibits enzyme activity but not its localization to target genes, mutant represses some adipogenic genes and inhibits adipocyte differentiation as does WT, but others arenot repressed and don't may not require its enzymatic activity and other H3K9 methyltransferases may be able to compensate. -CGAS cGAS EC 2.7.7.86 Q8N884 115004 6q13 human K411-ub 1881951902 CCRKDCLkLMKYLLE molecular association, regulation; enzymatic activity, inhibited DNA(DISRUPTS) 35503863 1 0 0 impairs cGAMP increased antiviral synthesis -Nos1 nNOS Amino Acid Metabolism - arginine and proline; EC 1.14.13.39; Oxidoreductase P29476 24598 12q16 rat K229-ac 2459102 GPAKAEMkDTGIQVD activity, induced 18415985 1 1 0 -MACROH2A2 H2AFY2 DNA-binding Q9P0M6 55506 10q22.1 human K12-ub 1877384701 SGKKKMSkLSRSARA Histone intracellular localization DNA repair, induced 32424115 1 0 0 recruiting downstream DNA repair proteins to DNA breaks -PRC1 PRC1 Cell cycle regulation; Cytoskeletal; Microtubule-binding; Motility/polarity/chemotaxis O43663 9055 15q26.1 human S577-p 26331401 FSINSVAsTYSEFAK phosphorylation 17351640 1 0 0 Docking site phosphorylation at T616 is regulated T578 phosphorylation. -LIPE HSL iso2 EC 3.1.1.79; Lipase Q05469-2 3991 19q13.2 human S552-p 448803 IAEPMRRsVSEAALA intracellular localization signaling pathway regulation 22493722 41 11 2 induces lipolysis -SCN5A SCN5A Channel, sodium; Membrane protein, integral; Membrane protein, multi-pass Q14524 6331 3p22.2 human R513-m1 37043705 MNHLSLTrGLSRTSM Na_trans_cytopl phosphorylation 25501501 1 1 0 inhibits SCN5A S516 phosphorylation -PTK2 FAK EC 2.7.10.2; KINASE; Kinase, protein; Protein kinase, TK; Protein kinase, tyrosine (non-receptor) Q05397 5747 8q24.3 human Y576-p 447889 RYMEDSTyYKASKGK PK_Tyr_Ser-Thr activity, induced; intracellular localization; phosphorylation; enzymatic activity, induced carcinogenesis, induced; cell differentiation, altered; cell growth, induced; cell motility, induced; cell adhesion, altered; cytoskeletal reorganization; transcription, altered 12482769; 15561106; 15707572; 15735019; 17088251; 18437915; 23716717; 35999654 95 65 2523 -MST1R Ron EC 2.7.10.1; KINASE; Kinase, protein; Membrane protein, integral; Protein kinase, TK; Protein kinase, tyrosine (receptor) Q04912 4486 3p21.31 human Y1317-p 456484 EYCPDSLyQVMQQCW PK_Tyr_Ser-Thr cell growth, altered 11064459 2 0 0 -MYL12B MRLC2 Contractile O14950 103910 18p11.31 human T19-p 448596 KKRPQRAtSNVFAMF cell motility, altered; cytoskeletal reorganization 11781833; 12429016; 18984162 36 50 282 -Jak1 JAK1 EC 2.7.10.2; KINASE; Kinase, protein; Protein kinase, TK; Protein kinase, tyrosine (non-receptor) P52332 16451 4 C6|4 46.19 cM mouse Y939-p 3345201 YHENIVKyKGICMED PK_Tyr_Ser-Thr enzymatic activity, inhibited 18682290 1 0 0 mutation Y939F increases activity of Jak1 in vitro -Slc9a1 NHE1 Membrane protein, integral; Membrane protein, multi-pass; Motility/polarity/chemotaxis; Transporter; Transporter, SLC family P26431 24782 5q36 rat S707-p 448347 MSRARIGsDPLAYEP apoptosis, induced 16717153 9 73 199 -LCK Lck EC 2.7.10.2; KINASE; Kinase, protein; Oncoprotein; Protein kinase, TK; Protein kinase, tyrosine (non-receptor) P06239 3932 1p35.2 human Y192-p 447821 NLDNGGFyISPRITF SH2 molecular association, regulation; enzymatic activity, inhibited; activity, inhibited; phosphorylation signaling pathway regulation ZAP70(DISRUPTS); LAT(DISRUPTS); PLCG1(DISRUPTS) 34321230; 8798764 5 29 1070 leads to lower ERK activation and less protein binding (pTyr proteins in lysates and pTyr peptides in vitro through Lck's SH2 domain); regulates phosphorylation of itself and inhibits ZAP70 and CD3Z phosphorylation, thus inhibiting TCR signaling -MYO9B MYO9B Actin-binding; GAP; GAP, Rac/Rho; Motility/polarity/chemotaxis; Motor Q13459 4650 19p13.11 human S1290-p 1983797 RVQEKPDsPGGSTQI cell differentiation, inhibited 30872405 1 71 3 -FOS Fos DNA-binding; Motility/polarity/chemotaxis; Oncoprotein; Transcription factor P01100 2353 14q24.3 human T325-p 448483 TELEPLCtPVVTCTP carcinogenesis, induced; transcription, induced 23667255 5 0 1 nuclear import of HBXIP -FGFR3 FGFR3 EC 2.7.10.1; KINASE; Kinase, protein; Membrane protein, integral; Protein kinase, TK; Protein kinase, tyrosine (receptor) P22607 2261 4p16.3 human Y760-p 448117 TVTSTDEyLDLSAPF molecular association, regulation; enzymatic activity, induced cell growth, altered SH2-B-beta(INDUCES) 11294897; 11827956 2 0 0 -Nefm NFM Cytoskeletal P08553 18040 14|14 D1 mouse S502-p 448041 EEPEAEKsPVKSPEA cytoskeletal reorganization 19193875 3 11 6 slightly altered axoplasmic organization in 7S/A mice mutant -CDCA5 CDCA5 Cell cycle regulation Q96FF9 113130 11q13.1 human S75-p 470993 VEVPAVQsPRRSPRI molecular association, regulation cell cycle regulation H2A.1(DISRUPTS); SMC3(DISRUPTS) 21878504 2 34 6 -Foxo1 FOXO1A DNA-binding; Nuclear receptor co-regulator; Oncoprotein; Transcription factor Q9R1E0 56458 3 C|3 23.19 cM mouse S273-p 1253812002 RAAKKKAsLQSGQEG apoptosis, induced; transcription, induced 33408127; 37263346 4 1 0 -PELI3 PELI3 Adaptor/scaffold; EC 6.3.2.-; EC 6.3.2.19; Ligase; UBIQUITIN LIGASE; Ubiquitin conjugating system; Ubiquitin ligase Q8N2H9 246330 11q13.2 human K316-ub 37043502 LLRAPTLkQLEAQRQ Pellino protein degradation autophagy, induced; transcription, inhibited 25483963 1 2 0 autophagy-dependent degradation -NUP98 NUP98 iso2 Motility/polarity/chemotaxis; Nucleoporin P52948-2 4928 11p15.4 human S595-p 470432 LNNSNLFsPVNRDSE intracellular localization 21335236 2 57 5 as multiple sites (13PM) mutant -Dbnl DBNL Actin-binding; Motility/polarity/chemotaxis Q62418 13169 11 A1|11 3.87 cM mouse Y350-p 450091 PPEQDTLyEEPPLVQ cell motility, induced; cytoskeletal reorganization; cell motility, inhibited 22303001; 30504273 4 1 22 cell migration to CP; extracellular matrix degradation, inhibits invasive cell migration -FTO FTO DEMETHYLASE; Demethylase; EC 1.14.11.- Q9C0B1 79068 16q12.2 human T150-p 23108331 NDYLQIEtIQALEEL FTO_NTD intracellular localization cell cycle regulation; cell growth, inhibited; RNA stability, inhibited 32268083 1 0 1 -Slc12a1 NKCC2 Membrane protein, integral; Membrane protein, multi-pass; Transporter; Transporter, SLC family P55016 25065 3q36 rat T101-p 458228 LQTFGHNtMDAVPKI AA_permease_N activity, induced; molecular association, regulation; intracellular localization ANXA2(DISRUPTS) 16275913; 18550832; 24526686 14 2 0 Low chloride hypotonic stress enhances raft association of NKCC2 and AnxA2; observed in triple mutant T96/111/101A -Strap STRAP Adaptor/scaffold; RNA splicing; UBIQUITIN LIGASE; Ubiquitin ligase Q9Z1Z2 20901 6|6 G1 mouse S188-p 38410205 NFNMSVSsMEYIPEG activity, induced apoptosis, induced; transcription, induced; signaling pathway regulation 25485581 1 0 0 induces apoptosis through Ask1, TGF-beta, p53 and PI3K/PDK1 signaling pathways -PPP1R3F PPP1R3F Membrane protein, integral; Protein phosphatase, regulatory subunit Q6ZSY5 89801 Xp11.23 human S421-p 22650301 AIRIPPSsPLCGLGG signaling pathway regulation 21668450 0 2 0 regulation of glycogen synthesis via R3F-PP1 signaling in astrocytoma cells -XRCC6 Ku70 DNA repair, damage; DNA-binding; EC 3.6.4.-; EC 4.2.99.-; Helicase; Nuclear receptor co-regulator; RNA-binding P12956 2547 22q13.2 human S78-p 1875071708 YISKIISsDRDLLAV Ku_N molecular association, regulation; acetylation; intracellular localization DNA repair, inhibited; transcription, inhibited 14-3-3 beta(INDUCES); SIRT1(DISRUPTS) DNA(DISRUPTS) 34635772 1 1 0 -TAGLN2 TAGLN2 Cytoskeletal; Motility/polarity/chemotaxis P37802 8407 1q23.2 human S163-p 468770 KENPRNFsDNQLQEG molecular association, regulation carcinogenesis, induced; cell motility, induced; cytoskeletal reorganization ACTB(DISRUPTS) 21577206 1 63 34 -RIGI RIGI EC 3.6.4.13; Hydrolase O95786 23586 9p21.1 human K146-ub 62480702 ILQICSTkGMMAGAE CARD_2 protein degradation transcription, inhibited 27506794 1 0 0 -CFTR CFTR Channel, chloride; EC 3.6.3.49; Hydrolase; Membrane protein, integral; Membrane protein, multi-pass; Transporter; Transporter, ABC family P13569 1080 7q31.2 human S790-p 2907510 IHRKTTAsTRKVSLA CFTR_R activity, induced 12588899 2 0 0 -Eif4b EIF4B RNA-binding; Translation; Translation initiation Q5RKG9 300253 7q36 rat S504-p 452271 SSDTEQPsPTSGGGK intracellular localization translation, induced 28874824 2 55 22 increased in Bassoon-positive synaptic areas, up-regulation of PKM? -Akt1 Akt1 EC 2.7.11.1; KINASE; Kinase, protein; Oncoprotein; Protein kinase, AGC; Protein kinase, Ser/Thr (non-receptor) P47196 24185 6q32 rat T308-p 447856 KDGATMKtFCGTPEY Pkinase molecular association, regulation; protein conformation; phosphorylation cell cycle regulation; carcinogenesis, induced; cell growth, induced; cell adhesion, induced; apoptosis, inhibited; signaling pathway regulation BAD(INDUCES) 11027222; 21736902; 22031698; 33864097; 34221817; 34335915; 34475824; 34569407 802 14 18 -PTPN6 SHP-1 EC 3.1.3.48; Motility/polarity/chemotaxis; PHOSPHATASE; Protein phosphatase, tyrosine (non-receptor) P29350 5777 12p13.31 human S553-p 15415001 KNAHAKAsRTSSKHK enzymatic activity, induced cell adhesion, induced; signaling pathway regulation 21177494 1 0 2 Src activation via SHP-1 and SHP-2, and then ERK activation -MARS1 MARS Aminoacyl-tRNA synthetase; EC 6.1.1.10; Ligase; Other Amino Acids Metabolism - selenoamino acid; Translation; Translation regulation P56192 4141 12q13.3 human S825-p 3193240 GGGQAKTsPKPAVVE methylation; enzymatic activity, induced cell growth, induced; transcription, induced; translation, induced 25097229 1 32 7 induces Met-misacylation; reduce intracellular ROS level -RTCB RTCB EC 6.5.1.3 Q9Y3I0 51493 22q12.3 human Y306-p 55380503 ASPEGQDyLKGMAAA RtcB molecular association, regulation RNA splicing, inhibited; apoptosis, inhibited; signaling pathway regulation IRE1(DISRUPTS) 35193953 1 2 0 regulates IRE1-XBP1/RIDD signaling -CETN2 CETN2 Calcium-binding; Cell cycle regulation; DNA repair, damage P41208 1069 Xq28 human S158-p 34405001 RDGDGEVsEQEFLRI EF-hand_7 molecular association, regulation XPC(DISRUPTS) 24918055 1 0 0 -ATP7B ATP7B EC 3.6.3.54; Hydrolase; Membrane protein, integral; Membrane protein, multi-pass; Transporter; Transporter, ion channel; Vesicle P35670 540 13q14.3 human S341-p 25786201 SGTDHRSsSSHSPGS intracellular localization; protein conformation 22898812 1 0 0 mutant does not return to TGN in response to copper depletion; S340/341A mutant shifts ATP7B from trans-Golgi Network (TGN) to vesicles -CD3G CD3G Membrane protein, integral; Receptor, misc. P09693 917 11q23.3 human S148-p 451430 GVRQSRAsDKQTLLP receptor internalization, altered; activity, inhibited 8187769; 8626701 5 1 3 -Pik3ap1 BCAP Adaptor/scaffold Q9EQ32 83490 19|19 C3 mouse Y420-p 450044 GEEADDVyESMAHLS molecular association, regulation cell differentiation, altered PIK3R1(INDUCES) 18025150 2 0 9 regulate Akt activation and B-cell differentiation through binding to PI3KR1 -SMARCA4 SMARCA4 Cell cycle regulation; EC 3.6.1.-; EC 3.6.4.-; Helicase; Nuclear receptor co-regulator; Transcription, coactivator/corepressor; Tumor suppressor P51532 6597 19p13.2 human S721-p 481804 VDDEYGVsQALARGL molecular association, regulation DNA repair, induced H3(INDUCES) 24413084 1 1 4 enhances binding to gamma-H2AX nucleosomes and acetylated H3 peptides -MAD2L1 MAD2L1 Cell cycle regulation Q13257 4085 4q27 human S195-p 468160 TTIHKVNsMVAYKIP HORMA molecular association, regulation; protein conformation; activity, inhibited cell cycle regulation Mad1(DISRUPTS); CDC20(DISRUPTS) 12574116; 21041666 2 14 20 MAD2L1 S195D mutant bound to Mad1 with lower affinity in vitro but higher in vivo, as compared to MAD2L1-wt -Hdgf HDGF Cytokine; Transcription regulation Q8VHK7 114499 2q34 rat S103-p 18944905 KASGYQSsQKKSCAE activity, induced cell cycle regulation; cell growth, induced 21489262 1 3 0 -Gphn gephyrin Adaptor/scaffold; EC 2.10.1.1; EC 2.7.7.75 Q03555 64845 6q24 rat T289-p 31878238 ESPRAQAtSRLSTAS molecular association, regulation gephyrin(INDUCES) 22778260 1 2 0 oligomerization -BNIP3 BNIP3 Membrane protein, integral; Mitochondrial Q12983 664 10q26.3 human S24-p 27421703 SWVELHFsNNGNGGS BNIP3 molecular association, regulation; intracellular localization autophagy, induced LC3B(INDUCES); GABARAPL2(INDUCES) 23209295 1 0 0 S82 is required for binding and S89 positively regulates the affinity for LC3B and GABARAPL2. Mitochondrial degradation. -Nfil3 E4BP4 DNA-binding; Transcription factor O08750 18030 13 B1|13 27.68 cM mouse K219-sm 55429871 ENKFPVIkQEPVELE Vert_IL3-reg_TF transcription, inhibited 29311361 1 4 0 NK cell production inhibited -Slc11a2 SLC11A2 Membrane protein, integral; Membrane protein, multi-pass; Transporter; Transporter, SLC family P49282 18174 15 F1|15 56.29 cM mouse S43-p 59087904 LPHSTGDsEEPFTTY activity, induced 27681840 1 0 0 iron uptake -TTK TTK Cancer Testis Antigen (CTA); EC 2.7.12.1; KINASE; Kinase, protein; Protein kinase, Other; Protein kinase, dual-specificity (non-receptor) P33981 7272 6q14.1 human S436-p 950200 VFSVSKQsPPISTSK cytoskeletal reorganization 22430208 3 22 3 centrosome reduplication -ERN1 IRE1 Apoptosis; Chaperone; EC 2.7.11.1; Endoplasmic reticulum; KINASE; Kinase, protein; Membrane protein, integral; Protein kinase, Other; Protein kinase, Ser/Thr (non-receptor); Ribonuclease O75460 2081 17q23.3 human Y628-p 41192601 EHPNVIRyFCTEKDR Pkinase protein conformation 25968568 1 0 0 The apo-hIRE1 dimer is twisted compared to the phos-yIRE1 dimer, and the RNase domains are further apart. -PAK1 PAK1 EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, STE; Protein kinase, Ser/Thr (non-receptor) Q13153 5058 11q13.5-q14.1 human S144-p 448170 SNSQKYMsFTDKSAE intracellular localization; enzymatic activity, induced carcinogenesis, induced; cell growth, induced; cell adhesion, induced; apoptosis, inhibited; cytoskeletal reorganization; signaling pathway regulation 15333633; 21177766; 31660987; 36319849 24 28 138 induces the MAPK pathway; Inhibitors decreased the tumor growth by inhibiting the phosphorylation; PAK activation induces PAK translocation, increased membrane permeability and MRLC1 phosphorylation. -HDAC6 HDAC6 DEACETYLASE; Deacetylase; EC 3.5.1.98; Nuclear receptor co-regulator; Ubiquitin conjugating system Q9UBN7 10013 Xp11.23 human S412-p 56668621 DPCPMLEsPGAPCRS molecular association, regulation cell motility, induced PIN1(INDUCES) 30443180 1 2 0 nteraction of HDAC6 with Pin1 mediates cell motility -Rb1 Rb Nuclear receptor co-regulator; Oncoprotein; Transcription, coactivator/corepressor; Tumor suppressor P13405 19645 14 38.73 cM|14 D3 mouse S605-p 447977 MYLSPLRsPKKRTST molecular association, regulation cell cycle regulation; cell growth, induced; transcription, inhibited E2F1(DISRUPTS) 10207050; 35023164; 9671466 13 18 33 transcriptional downregulation of the E2F-1, E2F-2, dihydrofolate reductase, thymidine kinase, c-myc, proliferating-cell nuclear antigen, p107, and p21/Cip1 genes -SYK Syk EC 2.7.10.2; KINASE; Kinase, protein; Protein kinase, TK; Protein kinase, tyrosine (non-receptor) P43405 6850 9q22.2 human Y525-p 447661 ALRADENyYKAQTHG PK_Tyr_Ser-Thr enzymatic activity, induced carcinogenesis, induced; carcinogenesis, inhibited; cell growth, induced ITGAM(INDUCES) 11380624; 18818202; 30923129; 34132782; 37330581; 8657103 50 8 76 -IKBKB IKKB EC 2.7.11.10; KINASE; Kinase, protein; Protein kinase, Other; Protein kinase, Ser/Thr (non-receptor) O14920 3551 8p11.21 human Y199-p 449633 ELLEQQKyTVTVDYW Pkinase activity, induced; molecular association, regulation transcription, altered 12645577; 12707358; 26353931 6 1 0 -RB1 Rb Nuclear receptor co-regulator; Oncoprotein; Transcription, coactivator/corepressor; Tumor suppressor P06400 5925 13q14.2 human K874-ac 459027 NPPKPLKkLRFDIEG Rb_C molecular association, regulation; intracellular localization; phosphorylation cell cycle regulation; cell differentiation, induced; transcription, induced E2F1(DISRUPTS); MDM2(INDUCES) 11433299; 15044952; 16374512 4 1 0 -TFAP2A AP-2 alpha DNA-binding; Transcription factor P05549 7020 6p24.3 human S219-p 25581601 CSVPGRLsLLSSTSK TF_AP-2 activity, induced; molecular association, regulation transcription, induced DNA(INDUCES) 22561688; 27391154 3 0 0 IkB-alpha expression -LARP6 LARP6 Q9BRS8 55323 15q23 human S348-p 54436202 DPESNPTsPMAGRRH molecular association, regulation; intracellular localization translation, induced STRAP(INDUCES) 28112218 2 1 0 regulates collagen production, contributes to LARP6 nuclear distribution, asssociation of LARP6 with ER membrane. -RPS6 S6 Translation P62753 6194 9p22.1 human S235-p 448092 IAKRRRLsSLRASTS activity, induced; molecular association, regulation; enzymatic activity, induced cell cycle regulation; carcinogenesis, induced; carcinogenesis, inhibited; apoptosis, induced; cell motility, induced; signaling pathway regulation; cell growth, induced; apoptosis, inhibited RNA(INDUCES) 17360704; 20008839; 21601007; 21750219; 25738361; 34273354; 34523696; 34737445; 35596155; 35998013; 36216931; 36409827; 36635496; 36715448 246 60 972 -POU3F2 Oct7 DNA-binding; Motility/polarity/chemotaxis; Transcription factor P20265 5454 6q16.1 human S91-p 1868139200 GGGGGDGsPWSTSPL DNA repair, altered; signaling pathway regulation DNA(INDUCES) 30804224 1 0 0 -TUBA1A TUBA1A Cytoskeletal; Motility/polarity/chemotaxis Q71U36 7846 12q13.12 human K166-sm 1881132900 VDYGKKSkLEFSIYP sumoylation cytoskeletal reorganization 33394042 1 0 0 promotes microtubule catastrophe, attenuates MT polymerization, facilitates neurite extension -Cidec CIDEC Apoptosis P56198 14311 6|6 E3 mouse K236-ub 12718505 SLLPACLkMLQ____ protein degradation 20089860 1 0 0 -NFYB NFYB DNA-binding; Transcription factor P25208 4801 12q23.3 human K140-ub 22248373 PLKLYLQkFREAMKG molecular association, regulation; ubiquitination; methylation transcription, induced DNA(INDUCES) 23332751 1 1 0 -MAP4K1 HPK1 EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, STE; Protein kinase, Ser/Thr (non-receptor) Q92918 11184 19q13.2 human T165-p 455473 ISAQIGAtLARRLSF Pkinase protein degradation; enzymatic activity, induced transcription, altered 15743830; 24362026 2 0 0 -CYLD CYLD DEUBIQUITINASE; EC 3.4.19.12; Protease; Tumor suppressor; Ubiquitin conjugating system; Ubiquitin-specific protease Q9NQC7 1540 16q12.1 human S418-p 4745557 TTENRFHsLPFSLTK CYLD_phos_site ubiquitination; enzymatic activity, induced signaling pathway regulation 15870263; 24614225; 34610306 5 31 22 induces RIPK2 deubiquitination, and NOD2 signaling -Mark2 MARK2 EC 2.7.11.1; EC 2.7.11.26; KINASE; Kinase, protein; Protein kinase, CAMK; Protein kinase, Ser/Thr (non-receptor) O08679 60328 1q43 rat S91-p 26573803 IDKTQLNsSSLQKLF Pkinase cytoskeletal reorganization 17442826 1 0 0 neurite outgrowth -PARL PSARL Apoptosis; EC 3.4.21.105; Membrane protein, integral; Membrane protein, multi-pass; Mitochondrial; Protease Q9H300 55486 3q27.1 human T69-p 471331 PRRSDPGtSGEAYKR protein processing 17116872 1 1 0 involved in mitochondrial fragmentation -DDR2 DDR2 EC 2.7.10.1; KINASE; Kinase, protein; Membrane protein, integral; Protein kinase, TK; Protein kinase, tyrosine (receptor) Q16832 4921 1q23.3 human Y741-p 456863 NLYSGDYyRIQGRAV PK_Tyr_Ser-Thr phosphorylation 16186108 1 5 22 Stimulates autophosphorylation. Autophosphorylation induces Shc binding (site not determined). -MRE11 MRE11A Cell cycle regulation; DNA repair, damage; DNA-binding; Deoxyribonuclease P49959 4361 11q21 human S689-p 452321 KGVDFESsEDDDDDP protein stabilization; molecular association, regulation PIH1D1(INDUCES) 28436950 1 37 7 -RUNX1 AML1 iso8 DNA-binding; Oncoprotein; Transcription factor Q01196-8 861 21q22.12 human S293-p 454400 QYLGSIAsPSVHPAT protein degradation cell differentiation, induced 16046550; 17015473; 22531928 7 3 28 -RIPK3 RIPK3 EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, Ser/Thr (non-receptor); Protein kinase, TKL Q9Y572 11035 14q12 human K518-ub 1877365902 GWYNHSGk_______ phosphorylation 33369872 1 1 0 TBZ-induced necroptosis, necroptotic cell death, necroptosis-induced RIPK3 phosphorylation -SNAI1 Snail1 C2H2-type zinc finger protein; Transcription factor O95863 6615 20q13.13 human S11-p 11493500 SFLVRKPsDPNRKPN activity, induced; protein degradation; acetylation; protein stabilization; molecular association, regulation; intracellular localization; activity, inhibited carcinogenesis, induced; carcinogenesis, altered; cell growth, induced; transcription, induced; transcription, altered 14-3-3 sigma(INDUCES); JUB(DISRUPTS); HDAC1(INDUCES); LOXL3(INDUCES); SAP30(INDUCES); HDAC2(INDUCES) 19923321; 20940406; 22276203; 22791710 5 0 0 induces deacetylation and HDAC activity induced; blocks EMT -PAK1 PAK1 EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, STE; Protein kinase, Ser/Thr (non-receptor) Q13153 5058 11q13.5-q14.1 human T423-p 448177 PEQSKRStMVGTPYW Pkinase activity, induced; molecular association, regulation; enzymatic activity, inhibited; protein conformation; phosphorylation; enzymatic activity, induced carcinogenesis, induced; cell growth, induced; cell motility, induced; apoptosis, induced; cell adhesion, induced; cytoskeletal reorganization; signaling pathway regulation CDC42 iso1(INDUCES); PAK1(INDUCES) 10551809; 15893667; 17254971; 19574218; 25174975; 25466889; 27003261; 28842430; 29058761; 31660987; 33657382; 34799729; 36198272 39 4 11 -MAML1 MAML1 Transcription, coactivator/corepressor Q92585 9794 5q35.3 human K217-sm 13310802 LSLNKELkQEPVEDL molecular association, regulation transcription, inhibited HDAC7(INDUCES) 20203086 1 0 0 -RET Ret EC 2.7.10.1; KINASE; Kinase, protein; Membrane protein, integral; Oncoprotein; Protein kinase, TK; Protein kinase, tyrosine (receptor) P07949 5979 10q11.21 human Y1062-p 447625 TWIENKLyGMSDPNW molecular association, regulation; enzymatic activity, induced; phosphorylation apoptosis, induced; apoptosis, inhibited; cytoskeletal reorganization; transcription, altered; cell growth, altered SHP-2(INDUCES); IRS1(INDUCES); RAPGEF1(INDUCES); SHC1(NOT_REPORTED); FRS2(INDUCES); DOK6(INDUCES); GAB1(INDUCES); SHC3(INDUCES); SHC1(INDUCES); PKCA(INDUCES); CRK(INDUCES); PIK3R1(INDUCES) 10445857; 10919641; 10995764; 11002419; 11061555; 11313948; 11360177; 11713247; 11886862; 11956105; 12242309; 12444552; 12527893; 12771945; 14981541; 15286081; 15677445; 17210721; 20682772; 8663426 42 2 2 -WASF2 WAVE2 Actin-binding; Motility/polarity/chemotaxis Q9Y6W5 10163 1p36.11 human T346-p 18715502 VGFGSPGtPPPPSPP molecular association, regulation cell motility, altered; cytoskeletal reorganization 21419341 1 0 0 regulates WRC (WAVE2 regulatory complex) interaction with Arp2/3 and lamellipodial protrusion -Otud5 OTUD5 DEUBIQUITINASE; EC 3.4.19.12; Protease; Ubiquitin-specific protease Q3U2S4 54644 X A1.1|X 3.54 cM mouse S503-p 483402 AGGDRATsPLVSLYP protein degradation; protein stabilization; molecular association, regulation; ubiquitination; phosphorylation; enzymatic activity, induced cell cycle regulation; cell growth, induced; autophagy, inhibited; transcription, altered; signaling pathway regulation BTRC(DISRUPTS) 33110214 1 21 1 inhibits ubiquitination and induces stabilization of OTUD5 and BTRCP1 further causing DEPTOR degradation, regulates phosphorylation of mTOR targets, promotes OTUD5-?TrCP1-DEPTOR pathway -PRKCD PKCD EC 2.7.11.13; KINASE; Kinase, protein; Nuclear receptor co-regulator; Protein kinase, AGC; Protein kinase, Ser/Thr (non-receptor); Protein kinase, tyrosine (non-receptor); Tumor suppressor Q05655 5580 3p21.1 human S359-p 6319238 HKVLGKGsFGKVLLG Pkinase enzymatic activity, altered 25755284 3 2 0 Y313 indirectly decreases phosphorylation in the kinase domain ATP-positioning loop at Ser359 -Kirrel2 KIRREL2 Cell adhesion; Membrane protein, integral Q7TSU7 243911 7|7 B1 mouse Y595-p 23119553 TKDPTNGyYRVRGVS protein processing; intracellular localization 26324709 1 2 1 -MARCKS MARCKS Actin-binding; Motility/polarity/chemotaxis P12624 613548 cow S158-p 447786 KKKKKRFsFKKSFKL MARCKS exocytosis, induced 22013076 26 15 10 Calcium mobilization, degranulation induced and dissociation of MARCK5 from plasma membrane. -PDCD1 PD-1 Apoptosis; Membrane protein, integral Q15116 5133 2q37.3 human Y223-p 50293000 VPVFSVDyGELDFQW molecular association, regulation; phosphorylation SHP-2(INDUCES); SHP-1(INDUCES) 15240681; 31189114 3 1 0 induces dephosphorylation of target substrates after binding to SHP -ACTN4 ACTN4 Cytoskeletal; Motility/polarity/chemotaxis O43707 81 19q13.2 human Y4-p 11498501 ____MVDyHAANQSY molecular association, regulation; intracellular localization; protein conformation; phosphorylation apoptosis, induced; cell motility, inhibited; cytoskeletal reorganization; cell growth, altered ACTA1(DISRUPTS); ACTB(DISRUPTS) 19920151; 26012634; 31664084 5 0 0 -DAGLA NSDDR EC 3.1.1.-; Hydrolase; Membrane protein, integral; Membrane protein, multi-pass Q9Y4D2 747 11q12.2 human S782-p 27807805 APLATMEsLSDTESL enzymatic activity, inhibited 23502535 1 3 0 -CARD11 CARD11 Adaptor/scaffold Q9BXL7 84433 7p22.2 human S116-p 466431 KEPTRRFsTIVVEEG molecular association, regulation Bcl-10(INDUCES) 16809782 1 0 1 -FUS hnRNP P2 DNA-binding; Nuclear receptor co-regulator; Oncoprotein; RNA splicing; RNA-binding; SUMO LIGASE P35637 2521 16p11.2 human R521-me 1873375602 RGEHRQDrRERPY__ intracellular localization KPNB2(DISRUPTS) 22968170 1 0 0 Arginines in the RGG3 domain are required for nuclear import of mutant hnRNP, and arginine methylation in this domain reduces KPNB2 binding. -Ppp1r1b DARPP-32 Motility/polarity/chemotaxis; Protein phosphatase, regulatory subunit Q6J4I0 360616 10q31 rat T34-p 448047 MIRRRRPtPALLFRV DARPP-32 enzymatic activity, inhibited; protein conformation; phosphorylation neural plasticity; cell motility, induced; signaling pathway regulation; transcription, altered PPP1CA(INDUCES) 15066157; 19651774; 21564097; 35835216; 8226946 67 6 44 -CD226 DNAM-1 Cell adhesion; Immunoglobulin superfamily; Membrane protein, integral Q15762 10666 18q22.2 human Y322-p 454845 DDTREDIyVNYPTFS activity, induced; phosphorylation cell growth, induced; cell adhesion, induced; signaling pathway regulation 12847109; 32265229 6 2 69 induces IFN-gamma secretion, phosphorylation of ERK, p38, AKT and hence TCR signaling -Cacybp CACYBP Adaptor/scaffold; Ubiquitin conjugating system Q9CXW3 12301 1|1 H2.1 mouse T184-p 15402545 KEKPSYDtEADPSEG SGS enzymatic activity, inhibited signaling pathway regulation 26085436 1 3 5 ERK and Elk-1 -Sox2 SOX2 Cell development/differentiation; DNA-binding; Transcription factor P48432 20674 3 A3|3 16.93 cM mouse S253-p 6738002 VKSEASSsPPVVTSS protein stabilization; molecular association, regulation; intracellular localization carcinogenesis, induced; transcription, induced DNA(INDUCES) 35944584 4 13 0 -FNIP1 FNIP1 Q8TF40 96459 5q31.1 human S938-p 1861699800 WDIPRNEsSDSALGD protein stabilization; molecular association, regulation; phosphorylation signaling pathway regulation HSP90A(INDUCES) DNA(INDUCES) 30699359 1 1 0 -TNNI3 TNNI3 Actin-binding; Motility/polarity/chemotaxis; Motor P19429 7137 19q13.42 human Y26-p 3545720 IRRRSSNyRAYATEP Troponin-I_N molecular association, regulation 25252176 1 2 7 accelerates Ca2+ dissociation from TNNI3 on the thin filament -Akt1 Akt1 EC 2.7.11.1; KINASE; Kinase, protein; Oncoprotein; Protein kinase, AGC; Protein kinase, Ser/Thr (non-receptor) P31750 11651 12 F1|12 61.2 cM mouse T308-p 447856 KDGATMKtFCGTPEY Pkinase activity, induced; protein degradation; molecular association, regulation; ubiquitination; intracellular localization; phosphorylation; enzymatic activity, induced cell cycle regulation; carcinogenesis, induced; apoptosis, altered; cell motility, induced; RNA stability, induced; cell motility, inhibited; signaling pathway regulation; cell differentiation, altered; RNA splicing, induced; cell growth, induced; translation, induced; cell growth, altered; transcription, induced; transcription, altered; neural plasticity; autophagy, induced; cell differentiation, induced; apoptosis, inhibited; autophagy, inhibited; cytoskeletal reorganization PPP2CA(INDUCES); PPP2R5B(INDUCES); HSP90A(NOT_REPORTED); CHIP(INDUCES) 10722653; 11445557; 11563975; 14623889; 18851840; 19325558; 20303298; 20332342; 21329884; 21550972; 21767636; 21775285; 21852229; 22509246; 28600288; 32116552; 33048163; 33664496; 33742122; 33836590; 33869980; 33876772; 34556581; 34664403; 34714866; 34910106; 34921114; 35210408; 35449295; 35489019; 35583996; 35641033; 35921893; 36198369; 36884349; 37384528; 37418003; 37610873 802 14 18 -PHOX2A PHOX2A DNA-binding; Transcription factor O14813 401 11q13.4 human S206-p 9400300 GLASPRLsPSPLPVA molecular association, regulation; phosphorylation transcription, inhibited DNA(DISRUPTS) 19564421 1 1 0 regulates phosphorylation of PHOX2A S153; inhibits neuronal differentiation -ESRRG ERR3 DNA-binding; Nuclear receptor; Transcription factor P62508 2104 1q41 human S45-p 1725304 FIKTEPSsPASLTDS sumoylation transcription, inhibited 19067653 2 0 0 -Mef2c MEF2C DNA-binding; Transcription factor Q8CFN5 17260 13 C3|13 43.68 cM mouse S59-p 447999 NKLFQYAsTDMDKVL transcription, induced 8663403 2 0 0 -CFLAR CFLAR Apoptosis O15519 8837 2q33.1 human K167-ub 27811902 HRIDLKTkIQKYKQS DED protein degradation; ubiquitination apoptosis, induced 23519470; 28218919 3 1 0 concomitant sensitization of cancer cells to TRAIL-induced apoptosis; required for ROS-dependent degradation of CFLAR; mutation of T166, K167 or both ablates ROS-dependent CFLAR ubiquitination and degradation -Gsk3a GSK3A EC 2.7.11.1; EC 2.7.11.26; KINASE; Kinase, protein; Protein kinase, CMGC; Protein kinase, Ser/Thr (non-receptor) P18265 50686 1q21 rat S21-p 448584 SGRARTSsFAEPGGG enzymatic activity, inhibited apoptosis, altered 11035810; 20841359 156 24 277 phosphorylation decreases apoptosis -GSTP1 GSTP1 EC 2.5.1.18; Other Amino Acids Metabolism - glutathione; Transferase; Xenobiotic Metabolism - drug metabolism - cytochrome P450; Xenobiotic Metabolism - metabolism by cytochrome P450 P09211 2950 11q13.2 human S43-p 455117 VETWQEGsLKASCLY GST_N activity, induced 15604283 2 2 2 -EWSR1 EWS Oncoprotein; RNA-binding; Transcription, coactivator/corepressor Q01844 2130 22q12.2 human T79-p 7359501 QPPTGYTtPTAPQAY molecular association, regulation; intracellular localization cell cycle regulation AurB(INDUCES) 33293370 2 0 0 induces aneuploidy in EWS/FLI1 cells; as EWS/FLI1 fusion -PTEN PTEN Carbohydrate Metabolism - inositol phosphate; EC 3.1.3.16; EC 3.1.3.48; EC 3.1.3.67; Motility/polarity/chemotaxis; Nuclear receptor co-regulator; PHOSPHATASE; Phosphatase, lipid; Tumor suppressor P60484 5728 10q23.31 human T382-p 448314 DHYRYSDtTDSDPEN molecular association, regulation; protein stabilization; intracellular localization; enzymatic activity, inhibited; protein conformation; phosphorylation; enzymatic activity, altered cell cycle regulation; neural plasticity; cell differentiation, altered; carcinogenesis, inhibited; chromatin organization, altered; cell motility, altered; transcription, altered PTEN(DISRUPTS); AIP1(DISRUPTS) DNA(INDUCES) 10866658; 11035045; 11431330; 17240336; 17565999; 22413754; 24766807; 25823029; 35240162; 36155262 22 2 0 induces EGFR degradation; regulates CHK1 phosphorylation and activation and H2AX phosphorylation -Pfn1 profilin 1 Actin-binding; Cytoskeletal; Motility/polarity/chemotaxis P62962 18643 11 B3|11 43.21 cM mouse S138-p 2850008 MASHLRRsQY_____ Profilin cytoskeletal reorganization 33108594 9 0 0 -TEK TIE2 EC 2.7.10.1; KINASE; Kinase, protein; Membrane protein, integral; Protein kinase, TK; Protein kinase, tyrosine (receptor) Q02763 7010 9p21.2 human Y897-p 459394 GACEHRGyLYLAIEY PK_Tyr_Ser-Thr enzymatic activity, inhibited 11080633 1 1 25 -PRKACA PKACA EC 2.7.11.11; KINASE; Kinase, protein; Protein kinase, AGC; Protein kinase, Ser/Thr (non-receptor) P17612 5566 19p13.12 human S11-p 469998 AAAAKKGsEQESVKE protein conformation 21740913 4 4 0 -KDM4B JMJD2B DEMETHYLASE; Demethylase; EC 1.14.11.-; Oxidoreductase O94953 23030 19p13.3 human K337-ub 31914119 YELWKQGkDLTVLDH protein degradation 23589305 1 3 0 -CFTR CFTR Channel, chloride; EC 3.6.3.49; Hydrolase; Membrane protein, integral; Membrane protein, multi-pass; Transporter; Transporter, ABC family P13569 1080 7q31.2 human S641-p 2907508 QNLQPDFsSKLMGCD CFTR_R activity, induced; protein conformation; activity, inhibited 12588899; 14695900; 32123855 3 0 0 -RASSF1 RASSF1 iso2 Tumor suppressor Q9NS23-2 11186 3p21.31 human S203-p 484000 TSVRRRTsFYLPKDA RA protein degradation; molecular association, regulation; ubiquitination cell cycle regulation; apoptosis, altered; apoptosis, inhibited; cytoskeletal reorganization; transcription, altered TUBA1A(DISRUPTS); SKP2(INDUCES); CDC20(DISRUPTS) 17563743; 18071316; 18514071; 19276349; 20655196; 21874044 7 10 1 APC/C-dependent ubiquitination of RASSF1 -TPX2 TPX2 Cell cycle regulation; Microtubule-binding Q9ULW0 22974 20q11.21 human S486-p 455699 LPITVPKsPAFALKN TPX2_importin protein stabilization carcinogenesis, induced; cell motility, induced; cell growth, induced 31272499 1 38 108 -Cldn1 Claudin-1 Cytoskeletal; Membrane protein, integral; Membrane protein, multi-pass O88551 12737 16|16 B2 mouse T203-p 451428 PRPYPKPtPSSGKDY intracellular localization 15051488 1 0 0 -Dok7 DOK7 Activator; Adaptor/scaffold Q18PE0 231134 5|5 B2 mouse Y396-p 17535701 CPPGAAEyQVPTSLR molecular association, regulation; phosphorylation MUSK(INDUCES); CRKL(INDUCES); CRK(INDUCES) 21041412 2 2 0 plays an important role in AChR clustering; stimulates MuSK and AChR phosphorylation -Rbl2 Rb-like 2 Transcription, coactivator/corepressor; Tumor suppressor Q64700 19651 8 C4|8 44.25 cM mouse S636-p 449726 DEIYIAGsPLTPRRV molecular association, regulation cell cycle regulation DNA(DISRUPTS) 36542833 4 24 31 -KRT6A K6a Cytoskeletal P02538 3853 12q13.13 human K204-ub 348335700 LLQEQGTkTVRQNLE Filament ubiquitination 29191848 1 1 0 -Atp12a ATP12A EC 3.6.3.10; Energy Metabolism - oxidative phosphorylation; Hydrolase; Membrane protein, integral; Membrane protein, multi-pass; Transporter; Transporter, ion channel P54708 171028 15p12 rat S955-p 465553 IRKTRRNsIFQQGLF Cation_ATPase_C activity, induced; protein stabilization; intracellular localization 16738016 1 0 0 important for transporter functions -CDC25C CDC25C EC 3.1.3.48; Motility/polarity/chemotaxis; PHOSPHATASE; Protein phosphatase, dual-specificity P30307 995 5q31.2 human K151-ub 485772 MCSSSANkENDNGNL protein degradation cell cycle regulation; cell growth, inhibited 11842186 1 0 2 -Syn2 SYN2 Vesicle Q64332 20965 6 E3|6 53.2 cM mouse S10-p 449839 NFLRRRLsDSSFIAN Synapsin_N intracellular localization 17341582 6 1 0 Mutation S10A synapsin inhibits basal cell surface Glut4 four-fold. -CACNA1H CACNA1H Cell development/differentiation; Channel, calcium; Membrane protein, integral; Membrane protein, multi-pass O95180 8912 16p13.3 human S1198-p 22648004 TPLRRAEsLDPRPLR signaling pathway regulation 16917542 2 0 0 -OCLN occludin Cell adhesion; Membrane protein, integral; Membrane protein, multi-pass; Motility/polarity/chemotaxis Q91049 chicken Y383-p 458611 ESQYETDyTTAVESS molecular association, regulation; intracellular localization ZO1(INDUCES) 19017651 1 4 6 -KRT8 K8 Cytoskeletal P05787 3856 12q13.13 human S432-p 448540 SAYGGLTsPGLSYSL intracellular localization carcinogenesis, induced; carcinogenesis, inhibited; cell motility, induced; cell growth, inhibited; apoptosis, induced; cell motility, inhibited; cell motility, altered; cytoskeletal reorganization 10623656; 15368451; 17158917; 19115206; 21840417; 22114688; 22344252; 26303380; 27403885; 28209923; 29796162; 32365802 27 8 23 phosphorylation reduces keratin filament length, formation of connectivity-depleted and mechanically weaker networks; enhanced migration and invasion; reorganization of keratin filaments to perinuclear ring; induces solubility of keratin filaments and inhibits polymerization -ITGB3 ITGB3 Cell adhesion; Membrane protein, integral; Motility/polarity/chemotaxis P05106 3690 17q21.32 human Y785-p 448013 STFTNITyRGT____ Integrin_b_cyt molecular association, regulation; intracellular localization; protein processing; activity, inhibited cytoskeletal reorganization; cell adhesion, altered GRB2(INDUCES); kindlin-2(DISRUPTS); SHC1(INDUCES); tensin 1 iso1(INDUCES) 11723131; 14996908; 15699036; 16935858; 17473008; 20702409; 8631894 21 2 6 -PBRM1 polybromo 1 DNA-binding; Tumor suppressor Q86U86 55193 3p21.1 human S948-p 453717 SGLHRTYsQDCSFKN transcription, inhibited 25066234 1 17 33 early DNA repair -DPYSL3 CRMP-4 Hydrolase Q14195 1809 5q32 human S518-p 458799 KGGTPAGsARGSPTR carcinogenesis, induced 30154149 1 23 10 -Cd300a MAIR-I Immunoglobulin superfamily; Membrane protein, integral Q6SJQ0 217303 11 E2|11 80.54 cM mouse Y262-p 455226 SQVEVVEySTLALPQ SIT molecular association, regulation SHIP(INDUCES); SHP-2(INDUCES); SHP-1(INDUCES) 15569773 1 1 7 -PAK1 PAK1 EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, STE; Protein kinase, Ser/Thr (non-receptor) Q13153 5058 11q13.5-q14.1 human Y201-p 487519 PEHTKSVyTRSVIEP protein stabilization; molecular association, regulation; intracellular localization; enzymatic activity, induced carcinogenesis, induced; apoptosis, altered; cell motility, induced; transcription, induced; signaling pathway regulation; cell growth, induced; cell motility, altered; cytoskeletal reorganization GIT1(INDUCES); ARHGEF7(INDUCES); Snail1(INDUCES) 17726028; 21566085; 21719533; 23340249; 25125660; 25466889; 26944939; 27003261; 27542844 9 0 0 PAK1 phosphorylation stimulates PRL-induced tumor metastasis -USP28 USP28 DEUBIQUITINASE; EC 3.4.19.12; Protease; Ubiquitin-specific protease Q96RU2 57646 11q23.2 human S67-p 467252 DERVKEPsQDTVATE molecular association, regulation; ubiquitination; enzymatic activity, induced carcinogenesis, induced; DNA repair, induced; apoptosis, altered KLHL2(DISRUPTS) 16901786; 31938050; 34611298 3 5 0 induces substrate deubiquitination -FLCN FLCN Tumor suppressor Q8NFG4 201163 17p11.2 human S62-p 3206874 NSRMRAHsPAEGASV protein degradation; molecular association, regulation; intracellular localization; activity, inhibited; enzymatic activity, induced; phosphorylation cell cycle regulation; carcinogenesis, induced; cell growth, induced; autophagy, inhibited; signaling pathway regulation FNIP2(INDUCES); RRAGC(DISRUPTS) 23874397; 31395606; 37083230 5 56 5 regulates mTORC1 localization and activity, induces TFEB phosphorylation; induces localization of mTORC1, increases phosphorylation of mTORC1 targets, regulates mTORC1 pathway -DAB1 DAB1 Adaptor/scaffold O75553 1600 1p32.2-p32.1 human Y220-p 447630 PETEENIyQVPTSQK molecular association, regulation CRK(INDUCES) 15316068 12 2 0 -H3C14 HIST2H3A/C/D DNA-binding Q71DI3 126961 1q21.2 human K4-m2 33597100 ____ARTkQTARKST Histone chromatin organization, altered; transcription, induced 20075197 1 0 0 -THRB TR-beta1 DNA-binding; Nuclear receptor P10828 7068 3p24.2 human K146-sm 27490403 LHPSYSCkYEGKCVI zf-C4 molecular association, regulation; intracellular localization cell growth, induced; cell differentiation, induced; transcription, induced; transcription, inhibited; signaling pathway regulation; transcription, altered CBP(DISRUPTS); N-CoR1(INDUCES) DNA(INDUCES); DNA(DISRUPTS) 22930759; 25572392 3 0 0 -RIPK1 RIPK1 EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, Ser/Thr (non-receptor); Protein kinase, TKL Q13546 8737 6p25.2 human S161-p 20536001 IADLGLAsFKMWSKL PK_Tyr_Ser-Thr enzymatic activity, induced 18408713 4 1 0 necroptosis regulation -APEX1 APE1 DNA repair, damage; DNA-binding; Deoxyribonuclease; EC 4.2.99.18; Endoplasmic reticulum; Hydrolase; Lyase; Nuclear receptor co-regulator; Nucleolus; Transcription, coactivator/corepressor P27695 328 14q11.2 human K32-ac 15207803 KSKTAAKkNDKEAAG acetylation; molecular association, regulation; intracellular localization; protein conformation; enzymatic activity, induced DNA repair, induced; cell growth, induced; cell growth, inhibited NPM1(DISRUPTS); XRCC1(INDUCES) RNA(DISRUPTS) 20699270; 22918947; 27994014 4 3 0 -NHERF1 NHERF Adaptor/scaffold; Motility/polarity/chemotaxis O14745 9368 17q25.1 human S280-p 470168 LAEAALEsPRPALVR EBP50_C molecular association, regulation; protein conformation cell cycle regulation; cell growth, inhibited; apoptosis, induced; cytoskeletal reorganization; cell adhesion, inhibited ACTB(INDUCES) 23775624; 30326259 4 84 121 increased cell invasion, regulates invadopodial activity, cell proliferation inhibited, development of VM network, regulates metastatic potency and organotropism -GAB1 GAB1 Adaptor/scaffold; Motility/polarity/chemotaxis Q13480 2549 4q31.21 human Y627-p 447948 KGDKQVEyLDLDLDS molecular association, regulation; phosphorylation cell cycle regulation SYP(INDUCES); SHP-2(INDUCES); PIK3R1(INDUCES) 11323411; 15574420; 9658397; 9890893 24 25 438 Binding of SHP-2 to Gab1 leads to ERK activation. -IKBKG IKKG Adaptor/scaffold; Protein kinase, regulatory subunit Q9Y6K9 8517 Xq28 human S17-p 50564412 LCEMVQPsGGPAADQ protein stabilization transcription, induced 27929056 1 0 3 -CEP250 CEP250 Cell cycle regulation Q9BV73 11190 20q11.22 human S2421-p 20831305 LDESLTQsLTSPGPV intracellular localization cell cycle regulation 21723128; 25660448 3 2 1 -Dlgap1 SAPAP1 Cytoskeletal P97836 65040 9q38 rat S77-p 9418959 FPRRHYTsQQELKDE protein degradation; ubiquitination cytoskeletal reorganization 21829588 1 0 0 -Pacsin1 PACSIN1 Adaptor/scaffold Q61644 23969 17|17 A3.3 mouse S358-p 4730500 QTYATEWsDDESGNP molecular association, regulation cytoskeletal reorganization RAC1(INDUCES) 23420842 1 4 1 dendritic spine formation; S358 phosphorylation disrupts PACSIN1-ARHGAP17-Rac complex which is essential for Rac1 hydrolysis. -CEBPA C/EBP-alpha DNA-binding; Transcription factor P49715 1050 19q13.11 human K161-sm 2793923 ALRPLVIkQEPREED protein degradation cell cycle regulation; cell differentiation, inhibited; cell growth, induced; transcription, inhibited 17671234; 30644437 5 1 0 MORC2 overexpression -IMMT IMMT Membrane protein, integral; Mitochondrial Q16891 10989 2p11.2|2 human S528-p 55571502 ELQFRRLsQEQVDNF Mitofilin intracellular localization 27153535 1 1 0 Parkin recruitment to mitochondria was negatively regulated by PKA-mediated phosphorylation of S528 of MIC60 and T11 of MIC19 -DDX1 DDX1 EC 3.6.4.13; Helicase; RNA-binding Q92499 1653 2p24.3 human S377-p 36406801 DEADGLLsQGYSDFI DEAD molecular association, regulation RNA(INDUCES) 25176654 1 0 0 induces binding and maturatiuon of pri-miRNAs -RPA1 RPA1 DNA-binding P27694 6117 17p13.3 human K163-ac 461501 SKAYGASkTFGKAAG molecular association, regulation DNA repair, induced XPA(INDUCES) 28854354; 28854355 2 4 21 -EGFR EGFR EC 2.7.10.1; KINASE; Kinase, protein; Membrane protein, integral; Oncoprotein; Protein kinase, TK; Protein kinase, tyrosine (receptor) P00533 1956 7p11.2 human Y978-p 457580 MARDPQRyLVIQGDE molecular association, regulation STAT5A(INDUCES); SHP-2(INDUCES) 16729043 1 4 3 -PRKAR1A PKAR1A Protein kinase, regulatory subunit P10644 5573 17q24.2 human S77-p 468450 KAGTRTDsREDEISP molecular association, regulation; enzymatic activity, inhibited PKACA(INDUCES) 23942052; 35977512 2 39 30 -Opn4 melanopsin GPCR, family 1; Membrane protein, integral; Membrane protein, multi-pass; Receptor, GPCR Q9QXZ9 30044 14|14 B mouse T389-p 23257069 YRSTHRStLSSQSSD molecular association, regulation; protein conformation ARRB1(INDUCES) 32236094 1 1 1 -MAP4 MAP4 Cytoskeletal; Motility/polarity/chemotaxis P27816 4134 3p21.31 human S787-p 448480 KAPEKRAsPSKPASA activity, inhibited cell cycle regulation; cytoskeletal reorganization 10791892; 25746230; 35081344 7 34 6 -HSF4 HSF4 Cell development/differentiation; DNA-binding; Transcription, coactivator/corepressor Q9ULV5 3299 16q22.1 human K206-ub 50792301 GPSNAGGkRKLSLML protein degradation 26319152 1 0 0 -Ddx4 DDX4 EC 3.6.4.13; Helicase Q61496 13206 13 D2.2|13 63.87 cM mouse K405-ac 11325118 RLMDIIGkEKIGLKQ DEAD molecular association, regulation RNA(DISRUPTS) 22223882 1 1 0 selective RNA-binding activity -Cgas cGAS EC 2.7.7.86 Q8C6L5 214763 9|9 E1 mouse S291-p 36128853 VEKEKPGsPAVTLLI Mab-21 enzymatic activity, inhibited 26440888 3 2 0 inhibits cytokine production and IFN response upon infection with DNA viruses -DRD3 DRD3 GPCR, family 1; Membrane protein, integral; Membrane protein, multi-pass; Receptor, GPCR P35462 1814 3q13.31 human S257-p 482886 LELKRYYsICQDTAL 7tm_1 receptor desensitization, altered; receptor internalization, altered FLNA(INDUCES) 17536008 1 0 0 -NFAT5 NFAT5 Transcription factor O94916 10725 16q22.1 human S134-p 6223353 NTVQQHPsTPKRHTV intracellular localization 21209322 1 2 3 -DAB2 DAB2 Adaptor/scaffold; Tumor suppressor P98082 1601 5p13.1 human S423-p 7320788 LESSVQSsPHDSIAI intracellular localization 21097498 1 3 0 displacement of Dab2 from the membrane -Slc12a3 NCCT Membrane protein, integral; Membrane protein, multi-pass; Transporter; Transporter, SLC family P59158 20497 8 C5|8 46.46 cM mouse S71-p 469631 AYEHYANsALPGEPR AA_permease_N activity, induced; ubiquitination 22846565; 25472608 15 2 1 -IRS1 IRS1 Adaptor/scaffold; Motility/polarity/chemotaxis P35568 3667 2q36.3 human S616-p 447562 DDGYMPMsPGVAPVP molecular association, regulation; intracellular localization; activity, inhibited signaling pathway regulation PIK3R1(DISRUPTS) 12917346; 16914728; 9335553 37 7 4 morphine-inhibited insulin receptor signaling; via cell fractionation experiments; Phosphorylated S616 results in an inhibition of insulin signaling. -Map4 MAP4 Cytoskeletal; Motility/polarity/chemotaxis P27546 17758 9 F2|9 59.83 cM mouse S760-p 448480 KVAEKRTsPSKPSSA intracellular localization cell differentiation, inhibited; apoptosis, induced; cytoskeletal reorganization 30327268; 35902952 7 34 6 -Nfat5 NFAT5 Transcription factor D3ZGB1 rat Y160-p 12127405 PKRHTVLyISPPPED activity, induced; intracellular localization transcription, induced 20585028 5 1 0 -KCNA5 Kv1.5 Channel, potassium; Membrane protein, integral; Membrane protein, multi-pass P22460 3741 12p13.32 human T15-p 465994 LENGGAMtVRGGDEA activity, induced; protein degradation; ubiquitination endocytosis, induced 16466689; 33676894 2 0 0 -EPAS1 HIF2A DNA-binding; Transcription factor Q99814 2034 2p21 human S484-p 1876807202 SSCSTPNsPEDYYTS protein stabilization; molecular association, regulation; ubiquitination carcinogenesis, induced; cell growth, induced; apoptosis, inhibited; transcription, induced USP33(INDUCES) 35191554 1 0 0 induces deubiquitination -NR1I2 PXR DNA-binding; Nuclear receptor O75469 8856 3q13.33 human T248-p 27839401 PHMADMStYMFKGII Hormone_recep molecular association, regulation transcription, induced DNA(DISRUPTS) 22976785 1 0 0 -Alyref2 Refbp2 DNA-binding; RNA-binding Q9JJW6 56009 1|1 H3 mouse R24-m1 13906418 RNQRRVNrGGGPRRN molecular association, regulation RNA(DISRUPTS) 20129943 1 1 0 -Zap70 ZAP70 EC 2.7.10.2; KINASE; Kinase, protein; Protein kinase, TK; Protein kinase, tyrosine (non-receptor) P43404 22637 1 B|1 15.41 cM mouse K25-ub 15400590 AEAEEHLkLAGMADG SH2 protein degradation 31061531 1 3 1 -Bcl2 Bcl-2 Apoptosis; Autophagy; Membrane protein, integral; Oncoprotein P10417 12043 1 E2.1|1 49.76 cM mouse S84-p 448396 ATAGPALsPVPPVVH molecular association, regulation; protein stabilization; protein conformation; phosphorylation cell cycle regulation; autophagy, induced; apoptosis, induced; apoptosis, inhibited BAX(DISRUPTS) 14660795; 32051584; 35183115 22 1 0 -Dpysl2 CRMP-2 Microtubule-binding; Motility/polarity/chemotaxis O08553 12934 14 D1|14 34.6 cM mouse T509-p 448083 PVCEVSVtPKTVTPA molecular association, regulation DRP1(DISRUPTS); RHOT2(DISRUPTS) 34685760 16 63 34 -PHB1 PHB Apoptosis; Cell cycle regulation; Chaperone; Mitochondrial; Motility/polarity/chemotaxis; Nuclear receptor co-regulator; Oncoprotein; Transcription, coactivator/corepressor P35232 5245 17q21.33 human T258-gl 6374002 LSRSRNItYLPAGQS phosphorylation 19238206 1 0 0 -ESR1 ER-alpha DNA-binding; Nuclear receptor; Transcription factor P03372 2099 6q25.1-q25.2 human K266-sm 3617606 RRGGRMLkHKRQRDD molecular association, regulation transcription, induced DNA(INDUCES) 15961505 1 0 0 -Jak2 JAK2 EC 2.7.10.2; KINASE; Kinase, protein; Oncoprotein; Protein kinase, TK; Protein kinase, tyrosine (non-receptor) Q62120 16452 19 C1|19 23.73 cM mouse Y913-p 3345200 QHDNIVKyKGVCYSA PK_Tyr_Ser-Thr enzymatic activity, inhibited cell growth, altered 18682290 1 0 0 mutation Y913F increases activity of Jak2 in vitro -PTPN18 BDP1 EC 3.1.3.48; Motility/polarity/chemotaxis; PHOSPHATASE; Protein phosphatase, tyrosine (non-receptor) Q99952 26469 2q21.1 human Y354-p 450261 GHAMADTyAVVQKRG molecular association, regulation TEC(INDUCES) 14679216 1 0 0 -PTEN PTEN Carbohydrate Metabolism - inositol phosphate; EC 3.1.3.16; EC 3.1.3.48; EC 3.1.3.67; Motility/polarity/chemotaxis; Nuclear receptor co-regulator; PHOSPHATASE; Phosphatase, lipid; Tumor suppressor P60484 5728 10q23.31 human K128-ac 470078 AIHCKAGkGRTGVMI molecular association, regulation; enzymatic activity, inhibited; phosphorylation cell cycle regulation; carcinogenesis, inhibited; signaling pathway regulation MTA1(INDUCES) 16829519; 25447541 3 0 0 decreases p-Akt at S473; regulation of PI3K/AKT pathway, reduced phosphorylation of Akt -STING1 STING Apoptosis; Endoplasmic reticulum; Membrane protein, integral; Membrane protein, multi-pass; Mitochondrial Q86WV6 340061 5q31.2 human Y240-p 1875847400 AGIKDRVySNSIYEL TMEM173 intracellular localization; phosphorylation transcription, induced 34933455 1 1 0 primes phosphorylation at S245 -FAF1 FAF1 Apoptosis; Nuclear receptor co-regulator Q9UNN5 11124 1p32.3 human S556-p 27996217 EREAIRLsLEQALPP protein degradation; molecular association, regulation; acetylation; ubiquitination; intracellular localization; phosphorylation transcription, induced; signaling pathway regulation GCN5(INDUCES) 30472208 1 3 0 induces de-aggregation of itself and ubiquitination and aggregation of MAVS, TBK1 and IRF3 phosphorylation and dimerization -PINX1 PINX1 Inhibitor; Nucleolus; Tumor suppressor Q96BK5 54984 8p23.1 human T317-p 14823404 EDATLEEtLVKKKKK protein degradation; ubiquitination 20573420 1 1 0 -EDNRA EDNRA GPCR, family 1; Membrane protein, integral; Membrane protein, multi-pass; Motility/polarity/chemotaxis; Receptor, GPCR P25101 1909 4q31.22-q31.23 human T403-p 2911712 TSVPMNGtSIQWKNH receptor desensitization, induced 24064210 1 1 0 Lack of S397, T403 and S404 influences desensitization to a greater extent compared than S391, S393, and T396 -PRKDC DNAPK DNA repair, damage; EC 2.7.11.1; KINASE; Kinase, protein; Nucleolus; Protein kinase, Ser/Thr (non-receptor); Protein kinase, atypical P78527 5591 8q11.21 human K3241-ac 11318517 CKFSMKMkMIDSARK FAT DNA repair, induced 27297111 1 3 5 regulates genomic stability and radiosensitivity of cells -Bcl2l1 Bcl-xL Apoptosis; Autophagy; Membrane protein, integral; Mitochondrial Q64373 12048 2 75.41 cM|2 H1 mouse S73-p 55588400 NGATGHSsSLDAREV apoptosis, induced 27239332 1 0 0 perinuclear clustering of mitochondria -TRIM32 TRIM32 EC 6.3.2.-; EC 6.3.2.19; Ligase; UBIQUITIN LIGASE; Ubiquitin conjugating system; Ubiquitin ligase Q13049 22954 9q33.1 human S335-p 3195095 SPEEVVAsPRASPAK intracellular localization cell growth, inhibited 25100564 1 25 0 promotes Asymmetric Cell Division -GLI1 GLI1 C2H2-type zinc finger protein; Oncoprotein; Transcription factor P08151 2735 12q13.3 human T374-p 457674 PGCTKRYtDPSSLRK zf-C2H2 intracellular localization; activity, inhibited transcription, altered 16293631 1 0 0 phosphorylation of this site inhibits the transport of GLI1 to the nucleus -DDB2 DDB2 DNA repair, damage Q92466 1643 11p11.2 human K35-ac 1876931102 LELEPEAkKLCAKGS DNA repair, induced 32789493 1 1 0 SIRT6 as a critical factor in the regulation of the process of UV-induced DNA damage repair -PPARA PPAR-alpha DNA-binding; Nuclear receptor; UBIQUITIN LIGASE Q07869 5465 22q13.31 human S280-p 1867858200 FHCCQCTsVETVTEL Hormone_recep activity, induced; molecular association, regulation transcription, induced RXRA(INDUCES) DNA(INDUCES) 30745182 1 1 0 -ATP7A ATP7A Apoptosis; Cell development/differentiation; Chaperone; EC 3.6.3.54; Hydrolase; Membrane protein, integral; Membrane protein, multi-pass; Transporter; Transporter, ion channel; Vesicle Q04656 538 Xq21.1 human S1432-p 4733392 QIGQKSPsEISVHVG intracellular localization 19576997 1 8 0 required for post-Golgi exocytic trafficking (Cu -responsive) -Plk4 PLK4 EC 2.7.11.21; KINASE; Kinase, protein; Nucleolus; Protein kinase, Other; Protein kinase, Ser/Thr (non-receptor) Q64702 20873 3|3 B mouse S285-p 12654000 TVEDSMDsGHATLST protein degradation; ubiquitination 20100909 1 1 0 -PRDX1 PRDX1 EC 1.11.1.15; Nuclear receptor co-regulator; Oxidoreductase Q06830 5052 1p34.1 human Y194-p 448924 DVQKSKEyFSKQK__ 1-cysPrx_C molecular association, regulation; intracellular localization; enzymatic activity, inhibited NOX1(INDUCES) 20178744 2 8 138 -Smad4 SMAD4 DNA-binding; Nuclear receptor co-regulator; Transcription, coactivator/corepressor P97471 17128 18 E2|18 49.51 cM mouse S367-p 1877718910 RFCLGQLsNVHRTEA MH2 intracellular localization carcinogenesis, inhibited 35895826 1 1 0 -Irf7 IRF7 DNA-binding; Transcription factor P70434 54123 7|7 F5 mouse S431-p 1276101 VSSLDSSsLGLCLSS transcription, induced DNA(INDUCES) 15743772 5 0 0 -Cryab CRYAB Chaperone; Heat shock protein P23928 25420 8q23 rat S45-p 448748 FSTATSLsPFYLRPP Crystallin protein degradation; intracellular localization; phosphorylation apoptosis, altered; cytoskeletal reorganization; signaling pathway regulation 12574148; 22870022; 24159092; 33220080 35 7 1 localization of phosphorylated alpha-BCs in the diabetic retina; regulates the dentritic functions of HspB5 -Trpc7 TRPC7 Channel, calcium; Membrane protein, integral; Membrane protein, multi-pass Q9WVC5 26946 13|13 B1 mouse T15-p 11164436 KNMQRRHtTLREKGR activity, inhibited 21402151 1 0 4 calcium influx inhibited -SIRT1 SIRT1 Apoptosis; DEACETYLASE; Deacetylase; EC 3.5.1.-; Nuclear receptor co-regulator Q96EB6 23411 10q21.3 human Y280-p 25311269 FRSRDGIyARLAVDF SIR2 molecular association, regulation transcription, inhibited STAT3(INDUCES) 29789426 1 0 1 -Fos Fos DNA-binding; Motility/polarity/chemotaxis; Oncoprotein; Transcription factor P01101 14281 12 D2|12 39.7 cM mouse K265-sm 3289000 SISNVELkAEPFDDF molecular association, regulation transcription, inhibited DNA(DISRUPTS) 23396363 2 3 0 -Gch1 GCH1 Cofactor and Vitamin Metabolism - folate biosynthesis; EC 3.5.4.16; Hydrolase P22288 29244 15p14 rat S72-p 487495 AYSSILRsLGEDPQR GTP_cyclohydroI enzymatic activity, induced 19762783 4 0 0 -ATP7A ATP7A Apoptosis; Cell development/differentiation; Chaperone; EC 3.6.3.54; Hydrolase; Membrane protein, integral; Membrane protein, multi-pass; Transporter; Transporter, ion channel; Vesicle Q04656 538 Xq21.1 human S1424-p 50479822 SYELPARsQIGQKSP protein stabilization; intracellular localization 29301787 1 1 1 translocation to membrane -GEM GEM G protein; G protein, monomeric; G protein, monomeric, RGK P55040 2669 8q22.1 human S23-p 2060100 QPQQQRWsIPADGRH protein stabilization; molecular association, regulation cytoskeletal reorganization; cell adhesion, altered 14-3-3 beta(INDUCES) 14701738 1 12 2 Mutation of either S23 or S289 inhibits binding to 14-3-3 -MAPRE2 RP1 Cytoskeletal Q15555 10982 18q12.1-q12.2 human S236-p 23140241 SSGSASKsDKDLETQ cell adhesion, inhibited 23844040 1 0 1 -H3C1 H3 DNA-binding P68431 8350 6p22.2 human K14-me 483043 ARKSTGGkAPRKQLA Histone transcription, induced 20093418 2 0 0 H3K9ac and H3K4 trimethylation were marked at the enhancer, while H3K46 was associated with the gene body where the RNA polymerase II occupied -ZWINT ZWINT Cell cycle regulation O95229 11130 10q21.1 human S262-p 20765003 MGRDPGVsFKAVGLQ Zwint molecular association, regulation; intracellular localization; phosphorylation cell cycle regulation ZW10(INDUCES) 21775627 1 1 0 inhibits phosphorylation of dynein and induces its recruitment with ZW10 to kinetochores, -TARDBP TDP-43 RNA-binding Q13148 23435 1p36.22 human K84-ac 50286964 YPKDNKRkMDETDAS intracellular localization 35264561 1 0 1 K84 nuclear-cytoplasmic trafficking -SNAP23 SNAP23 Vesicle O00161 8773 15q15.1-q15.2 human S23-p 9766096 ITDESLEsTRRILGL molecular association, regulation STX4(INDUCES) 12930825 1 5 1 -CASP3 CASP3 Apoptosis; EC 3.4.22.56; Motility/polarity/chemotaxis; Protease P42574 836 4q35.1 human T152-p 34488901 GDRCRSLtGKPKLFI Peptidase_C14 enzymatic activity, inhibited 29414778 1 0 0 -CSF3R GCSFR Membrane protein, integral; Receptor, cytokine Q99062 1441 1p34.3 human Y752-p 451834 GTSDQVLyGQLLGSP molecular association, regulation; phosphorylation cell differentiation, induced SOCS3(INDUCES); CISH(INDUCES) 12133942; 15470047; 17137800; 26296889 5 0 0 neutrophil development, Y752F mutant promoted monocyte development; decreases ERK phosphorylation -RCJMB04_5k17 CARD11 Adaptor/scaffold Q5F3W0 416476 chicken S668-p 457639 LERPFRPsVTSVGRI molecular association, regulation Bcl-10(INDUCES); MALT1(INDUCES) 18086859; 21157432 6 0 0 stimulates CBM complex formation, NF-kB activation and IL-2 or IFN-gamma production -BORA BORA Activator Q6PGQ7 79866 13q21.33 human S278-p 27724403 PISSPTFsPIEFQIG protein degradation; molecular association, regulation cell cycle regulation PIN1(INDUCES) 23442801; 23970419 2 2 0 required for mitotic entry -PICK1 PICK1 Adaptor/scaffold; Cell development/differentiation; Ligand, receptor tyrosine kinase Q9NRD5 9463 22q13.1 human S339-p 50642303 FQLQRLVsTMSKYYN Arfaptin molecular association, regulation GluR2(INDUCES) 26472923 1 0 0 S415 was essential for binding to GluA2 -PIK3C3 PIK3C3 Autophagy; Carbohydrate Metabolism - inositol phosphate; EC 2.7.1.137; Kinase, lipid; Motility/polarity/chemotaxis Q8NEB9 5289 18q12.3 human T668-p 14662701 ENLDLKLtPYKVLAT enzymatic activity, inhibited 20513426 1 0 0 -Bnip3l BNIP3L Apoptosis; Endoplasmic reticulum; Membrane protein, integral; Mitochondrial; Nuclear envelope Q9Z2F7 12177 14 D1|14 34.6 cM mouse S81-p 15719324 LLDAQHEsGQSSSRG BNIP3 autophagy, induced 28820284 1 4 0 mitophagy activity, neuroptrotective results in ischemic brains -ATG9A ATG9A Autophagy; Membrane protein, integral; Membrane protein, multi-pass; Vesicle Q7Z3C6 79065 2q35 human Y8-p 62382600 MAQFDTEyQRLEASY molecular association, regulation autophagy, induced AP1B1(INDUCES); AP1M2(INDUCES) 27934868 1 1 0 -Foxo1 FOXO1A DNA-binding; Nuclear receptor co-regulator; Oncoprotein; Transcription factor Q9R1E0 56458 3 C|3 23.19 cM mouse S326-p 448076 STISGRLsPIMTEQD molecular association, regulation; intracellular localization transcription, induced; transcription, inhibited DUSP6(INDUCES) 22503562; 22848439; 27875304 11 13 19 -CAV1 caveolin-1 Adaptor/scaffold; Motility/polarity/chemotaxis; Nuclear receptor co-regulator Q03135 857 7q31.2 human K39-ub 486852 MADELSEkQVYDAHT molecular association, regulation; intracellular localization UBXN6(INDUCES); VCP(INDUCES) 23335559 1 9 16 CAV1 ubiquitylation and binding to the VCP-UBXD1 complex and sorting into lysosomes -Cd200r1 CD200R Membrane protein, integral; Receptor, misc. Q9ES57 57781 16|16 B4 mouse Y286-p 458378 EEDEMQPyASYTEKS molecular association, regulation DOK2(INDUCES); DOK1(INDUCES) 16330532 1 1 2 -WNK4 WNK4 EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, Other; Protein kinase, Ser/Thr (non-receptor) Q96J92 65266 17q21.2 human Y1164-p 40407605 KKEIEDLySRLGKQP molecular association, regulation SHP-2(INDUCES) 25805816 1 1 0 SGK1-induced reversion of WNK4s ROMK inhibition -HADHA HADHA ACETYLTRANSFERASE; Acetyltransferase; Amino Acid Metabolism - lysine degradation; Amino Acid Metabolism - tryptophan; Amino Acid Metabolism - valine, leucine and isoleucine degradation; Carbohydrate Metabolism - butanoate; Carbohydrate Metabolism - propanoate; EC 1.1.1.211; EC 4.2.1.17; Lipid Metabolism - fatty acid; Lipid Metabolism - fatty acid elongation in mitochondria; Lipid Metabolism - unsaturated fatty acid biosynthesis; Lyase; Mitochondrial; Other Amino Acids Metabolism - beta-alanine; Oxidoreductase; Secondary Metabolites Metabolism - limonene and pinene degradation P40939 3030 2p23.3 human K383-ac 56842400 IAQVSVDkGLKTILK 3HCDH_N protein stabilization 27457618 2 0 0 3 sites can be acetylated or ubiquitylated, acetylation blocks ubiquitylation -TP73 p73 DNA-binding; Transcription factor; Tumor suppressor O15350 7161 1p36.32 human Y99-p 448428 SVPTHSPyAQPSSTF activity, induced; molecular association, regulation; ubiquitination apoptosis, induced; apoptosis, inhibited; transcription, induced; transcription, altered TIF1B(DISRUPTS); BUB3(INDUCES); PCQAP(INDUCES) 10391251; 20057499; 25893286 5 1 0 caspase-independent mitotic death (CIMD) ; PCQAP interacts with p73 only upon genotoxic stress, tumor suppressor and anti-metastatic functions -Ptprc CD45 EC 3.1.3.48; Membrane protein, integral; Motility/polarity/chemotaxis; PHOSPHATASE; Receptor protein phosphatase, tyrosine P06800 19264 1 E4|1 60.73 cM mouse S993-p 449973 SEPESDEsSDDDSDS Y_phosphatase enzymatic activity, induced 10066810 1 5 0 -TBXA2R TXA2-R iso2 GPCR, family 1; Membrane protein, integral; Membrane protein, multi-pass; Receptor, GPCR P21731-2 6915 19p13.3 human S145-p 469630 FSRPAVAsQRRAWAT 7tm_1 receptor desensitization, altered 16956790 2 0 0 -Ccdc88a girdin Actin-binding Q5SNZ0 108686 11|11 A3.3 mouse S237-p 4725935 SAQSPCGsPGMKRTE molecular association, regulation SLC3A2(INDUCES) 29538402 1 16 2 negatively regulates amino acid signaling -CDC42EP4 CDC42EP4 Cytoskeletal Q9H3Q1 23580 17q25.1 human S18-p 3212334 SVHSKRRsRADLTAE molecular association, regulation cell motility, induced; cytoskeletal reorganization CDC42(DISRUPTS); ARHGEF17(INDUCES); PARD6G(INDUCES) 25086031 1 11 0 ARHGEF-phosphoCEP4 interaction activates Rac, activated Rac increased filopodium formation -LLGL1 LLGL1 Cell adhesion; Cytoskeletal; Motility/polarity/chemotaxis Q15334 3996 17p11.2 human S663-p 449917 LKKSLRQsFRRIRKS intracellular localization 12725730; 34717957 3 16 8 -IL24 IL24 Motility/polarity/chemotaxis; Secreted; Secreted, signal peptide Q13007 11009 1q32.1 human S88-p 41122601 QAQDNITsARLLQQE activity, induced; intracellular localization cell cycle regulation; carcinogenesis, inhibited; cell growth, inhibited; cell motility, inhibited; signaling pathway regulation 26009991 1 0 0 IL24 maturation and secretion; activates Caspase-9, PARP, and JNK; inhibits the AKT signaling pathway -PSTPIP2 PSTPIP2 Actin-binding Q9H939 9050 18q21.1|tdb7990 human Y329-p 465051 NYSLVDDySLLYQ__ molecular association, regulation SHIP(INDUCES) 26304991 1 1 1 -Epha4 EphA4 EC 2.7.10.1; KINASE; Kinase, protein; Membrane protein, integral; Protein kinase, TK; Protein kinase, tyrosine (receptor) Q03137 13838 1 C4|1 39.55 cM mouse Y602-p 450857 TYVDPFTyEDPNQAV EphA2_TM enzymatic activity, induced cell motility, altered; cytoskeletal reorganization 10848605; 16102535 7 16 155 YY->EE mutation induced receptor clustering that induced growth cone collapse and axonal guidance problems.; in vitro -GH1 GH Hormone; Secreted; Secreted, signal peptide P01241 2688 17q23.3 human K141-ub 1881839500 SNVYDLLkDLEEGIQ protein degradation 34200910 1 1 0 K141R mutant increases its half-life and increase in half-life occurs in the bloodstream -LAT LAT iso2 Adaptor/scaffold; Membrane protein, integral O43561-2 27040 16p11.2 human K52-ub 31914109 YPRGIQFkRPHTVAP LAT protein degradation; ubiquitination 27221712 2 1 0 Y132 phosphorylation is required for ubiquitylation. -Eif2ak3 PERK EC 2.7.11.1; KINASE; Kinase, protein; Membrane protein, integral; Protein kinase, Other; Protein kinase, Ser/Thr (non-receptor); Translation Q9Z2B5 13666 6|6 C1 mouse Y561-p 30310301 QCQTESKyDSVSADV molecular association, regulation; activity, inhibited apoptosis, inhibited NCK1(INDUCES); NCK2(INDUCES) 24371088; 29941454 2 0 0 inhibits its activity and signaling; enhances insulin secretion and production -LRRC4C LRRC4C Cell development/differentiation; Membrane protein, integral Q9HCJ2 57689 11p12 human S631-p 3893278 PLLIRMNsKDNVQET molecular association, regulation PSD-95(INDUCES) 22922712 1 4 4 dendritic spine morphogenesis -NR4A1 Nur77 Apoptosis; DNA-binding; Nuclear receptor P22736 3164 12q13.13 human S95-p 471072 TSSSSATsPASASFK protein degradation; protein stabilization; molecular association, regulation; activity, inhibited cell cycle regulation; transcription, altered PIN1(INDUCES) DNA(DISRUPTS) 17023523; 22002310 2 0 0 required for cell proliferation; Phosphorylation inhibits transcription. -Pax6 PAX6 DNA-binding; Motility/polarity/chemotaxis; Transcription factor P63015 18508 2 E3|2 55.31 cM mouse T304-p 458809 QPIPQPTtPVSSFTS transcription, induced 16407227 1 0 1 -ERG ERG DNA-binding; Oncoprotein; Transcription factor P11308 2078 21q22.2 human T180-p 1870421703 KDDFQRLtPSYNADI SAM_PNT protein degradation; molecular association, regulation; ubiquitination carcinogenesis, inhibited; cell growth, inhibited; transcription, inhibited FBXW7(INDUCES) 32871104 1 0 0 -Brca1 BRCA1 EC 6.3.2.-; Nuclear receptor co-regulator; Transcription, coactivator/corepressor; Tumor suppressor; UBIQUITIN LIGASE; Ubiquitin conjugating system; Ubiquitin ligase P48754 12189 11 65.18 cM|11 D mouse S971-p 448526 QSVSPIRsSIKTDNR cell cycle regulation; DNA repair, induced 15485917; 35409089 10 0 0 -SLC40A1 SLC40A1 Membrane protein, integral; Membrane protein, multi-pass; Transporter; Transporter, SLC family Q9NP59 30061 2q32.2 human Y538-p 25589100 VAMGHIMyFRFAQNT TM receptor internalization, inhibited 22682226 1 0 0 regulates internalization partially but not hepcidin mediated internalization -NCOA3 SRC-3 ACETYLTRANSFERASE; Acetyltransferase; EC 2.3.1.48; Motility/polarity/chemotaxis; Nuclear receptor co-regulator; Transcription, coactivator/corepressor Q9Y6Q9 8202 20q13.12 human K723-ub 1505897100 CGDGNVVkQEQLSPK DUF4927 activity, induced; protein degradation; molecular association, regulation; ubiquitination transcription, induced; signaling pathway regulation ER-alpha(INDUCES) 17574025 1 0 0 -LLGL1 LLGL1 Cell adhesion; Cytoskeletal; Motility/polarity/chemotaxis Q15334 3996 17p11.2 human S673-p 449918 RIRKSRVsGKKRAAN intracellular localization 34717957 2 1 0 -CIRBP CIRBP RNA-binding; Spliceosome; Translation Q14011 1153 19p13.3 human S146-p 3891206 RDYYSSRsQSGGYSD intracellular localization 29432179 1 4 34 may be cause of its exclusion from the DNA-damaged regions -Notch1 Notch 1 Membrane protein, integral; Motility/polarity/chemotaxis; Oncoprotein; Receptor, misc.; Transcription factor Q01705 18128 2 A3|2 18.91 cM mouse S1791-p 35502500 LKPLKNAsDGALMDD intracellular localization cell differentiation, inhibited; transcription, induced 24662486 1 1 0 localized from cell surface to endosomes in the inactivated Notch 1 state, and from endosomes to the nucleus in the Notch 1 activated state; increased production of NICD -PRKAR1A PKAR1A Protein kinase, regulatory subunit P10644 5573 17q24.2 human S101-p 454354 RRRRGAIsAEVYTEE enzymatic activity, induced 29378851 2 2 0 PKACA enzymatic activity -NFKB1 NFkB-p105 DNA-binding; Transcription factor P19838 4790 4q24 human S337-p 449967 FVQLRRKsDLETSEP RHD_dimer transcription, altered 12947093; 17959673 5 1 0 required for DNA binding and transactivation -CD274 PD-L1 Membrane protein, integral Q9NZQ7 29126 9p24.1 human S184-p 63237405 GKTTTTNsKREEKLF C2-set_2 protein degradation; ubiquitination 27572267 1 0 0 -SYMPK Symplekin Motility/polarity/chemotaxis; RNA processing Q92797 8189 19q13.32 human K361-sm 2586340 DSTLKKMkLEPNLGE RNA splicing, altered; cell growth, induced 17923699 1 4 0 regulation of mRNA 3'-end processing- cleavage and polyadenylation -SNCA SNCA Adaptor/scaffold P37840 6622 4q22.1 human T64-p 1876998407 EKTKEQVtNVGGAVV Synuclein molecular association, regulation; intracellular localization transcription, altered SNCA(DISRUPTS) 37252975 1 2 0 -CTNND2 CTNND2 Actin-binding; Motility/polarity/chemotaxis Q9UQB3 1501 5p15.2 human T457-p 480958 TGTYRTStAPSSPGV phosphorylation cell motility, induced; cell growth, induced; signaling pathway regulation 34069970 2 2 0 induces phosphorylation of p21, regulates AKT/d-catenin/p21 signalling -STING1 STING Apoptosis; Endoplasmic reticulum; Membrane protein, integral; Membrane protein, multi-pass; Mitochondrial Q86WV6 340061 5q31.2 human K338-ac 1881818300 RHLRQEEkEEVTVGS protein degradation autophagy, induced; signaling pathway regulation beclin 1(INDUCES); STING(DISRUPTS) 37081450 1 1 0 Beclin1 mediated acetylation of STING, inhibits STING signal transduction, dimerization of STING -Baz2a BMZF-2 DNA-binding; Nucleolus; Transcription regulation Q91YE5 116848 10|10 D3 mouse K672-ac 8537513 RGRPPKIkMPELLNK molecular association, regulation transcription, inhibited RNA(DISRUPTS) 19578370 1 1 0 -IQCB1 IQCB1 Cell development/differentiation Q15051 9657 3q13.33|3q21.1 human K263-ub 21177000 GLRRLLSkQETGTEF intracellular localization cell cycle regulation; cytoskeletal reorganization 28498859 1 4 0 regulation of cilia formation -RPL11 RPL11 Motility/polarity/chemotaxis; Nucleolus; Ribosomal; Translation P62913 6135 1p36.11 human K144-ne 12067606 PGFSIADkKRRTGCI Ribosomal_L5_C protein stabilization; intracellular localization 19713960 1 0 0 -CERS6 LASS6 DNA-binding; Membrane protein, integral; Membrane protein, multi-pass Q6ZMG9 253782 2q24.3 human S347-p 22350312 RSDIESSsDEEDSEP enzymatic activity, induced 26887952 1 3 0 -NR1H4 NR1H4 DNA-binding; Nuclear receptor Q96RI1 9971 12q23.1 human Y77-p 1186568001 QISSSSYySNLGFYP molecular association, regulation; intracellular localization transcription, induced RXRA(INDUCES) 29968724 2 1 0 regulates response to cholestasis and bile acid levels, regulates gene expression -BSG BSG iso2 Immunoglobulin superfamily; Membrane protein, integral P35613-2 682 19p13.3 human S246-p 471136 LDDDDAGsAPLKSSG activity, inhibited; phosphorylation carcinogenesis, inhibited; cell growth, inhibited; cell motility, inhibited; signaling pathway regulation 31016558 1 36 0 inhibits Akt phosphorylation; decrease/inhibits STAT3 and Akt signaling -GRIN2A NMDAR2A Channel, ligand-gated; Membrane protein, integral; Membrane protein, multi-pass Q12879 2903 16p13.2 human Y1105-p 4109553 CSEVERTyLKTKSSS NMDAR2_C activity, induced 10195142 3 1 12 potentiation of receptor currents mediated by Src -CACB CACNA1C Channel, calcium; Membrane protein, integral; Membrane protein, multi-pass P15381 100101555 rabbit S1928-p 455278 ASLGRRAsFHLECLK CAC1F_C activity, induced; activity, inhibited 16648185; 20937253 31 3 0 -STARD3 STARD3 Membrane protein, integral; Membrane protein, multi-pass Q14849 10948 17q12 human S203-p 1876567502 LLFSGALsEGQFYSP MENTAL molecular association, regulation VAPA(INDUCES) 35231443 1 0 0 -MRE11 MRE11A Cell cycle regulation; DNA repair, damage; DNA-binding; Deoxyribonuclease P49959 4361 11q21 human R570-m2 62978403 SAATNKGrGRGRGRR DNA repair, altered 15741314 0 1 0 -PAK6 PAK6 EC 2.7.11.1; KINASE; Kinase, protein; Nuclear receptor co-regulator; Protein kinase, STE; Protein kinase, Ser/Thr (non-receptor) Q9NQU5 56924 15q15.1 human T99-p 3843654 LSVISSNtLRGRSPT molecular association, regulation; intracellular localization 14-3-3 sigma(INDUCES) 35969127 2 2 4 -Pak1 PAK1 EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, STE; Protein kinase, Ser/Thr (non-receptor) P35465 29431 1q32 rat S21-p 448174 APPMRNTsTMIGAGS molecular association, regulation NCK1(DISRUPTS) 10805734 3 0 10 -MITF MITF DNA-binding; Oncoprotein; Transcription factor O75030 4286 3p13 human S516-p 450265 KTSSRRSsMSMEETE DUF3371 protein degradation; molecular association, regulation; intracellular localization cell growth, inhibited; transcription, induced; transcription, inhibited ID4(INDUCES); 53BP1(INDUCES) 27702651 8 5 0 induces p21Cip1 expression; reduces TYR expression; cell proliferation arrest and senescence -RELA NFkB-p65 DNA-binding; Nuclear receptor co-regulator; Transcription factor Q04206 5970 11q13.1 human T305-gl 27490900 IEEKRKRtYETFKSI O-GlcNAc glycosylation; acetylation transcription, induced 23027940; 28416608 2 1 0 -CD19 CD19 Cell surface; Membrane protein, integral P15391 930 16p11.2 human Y439-p 469560 LSQDGSGyENPEDEP activity, induced; molecular association, regulation; phosphorylation PLCG2(INDUCES); VAV1(INDUCES) 10706702 1 0 0 ERK2 phosphorylation; Ca(2+) influx -SLC4A1 SLC4A1 Membrane protein, integral; Membrane protein, multi-pass; Transporter; Transporter, SLC family P02730 6521 17q21.31 human Y8-p 451570 MEELQDDyEDMMEEN molecular association, regulation LYN(INDUCES); ANK1(DISRUPTS) 10942405; 27856737 8 18 8 -SLC9A5 NHE5 Membrane protein, integral; Membrane protein, multi-pass; Transporter; Transporter, SLC family Q14940 6553 16q22.1 human S712-p 20832301 EEEESDSsETEKEDD molecular association, regulation; activity, inhibited endocytosis, induced ARRB1(INDUCES) 21296876 1 0 0 -RBL1 Rb-like 1 Transcription, coactivator/corepressor; Tumor suppressor P28749 5933 20q11.23 human S1009-p 27460997 LLYKFNGsPSKSLKD Rb_C molecular association, regulation E2F1(DISRUPTS) 28439018 1 5 0 -WAS WASP Adaptor/scaffold; Motility/polarity/chemotaxis P42768 7454 Xp11.23 human K144-sm 52504002 FRALVQEkIQKRNQR WH1 molecular association, regulation; acetylation transcription, altered; signaling pathway regulation COMMD1(DISRUPTS); HDAC6(DISRUPTS) 26261240 1 0 0 induces hypoacetylation at H3K14, regulates NF-kB signaling -Stub1 CHIP Adaptor/scaffold; EC 6.3.2.-; EC 6.3.2.19; Ligase; UBIQUITIN LIGASE; Ubiquitin conjugating system; Ubiquitin ligase Q9WUD1 56424 17 A3.3|17 12.93 cM mouse S20-p 453857 LGTGGGGsPDKSPSA molecular association, regulation; enzymatic activity, induced apoptosis, induced IL32(DISRUPTS) 26206088; 29111393 3 98 9 IL32-induced neuronal cell death; tAIF-mediated cell death in rotenone-treated cortical neurons, dysregulated Cdk5 activation -CDC6 CDC6 Cell cycle regulation Q99741 990 17q21.2 human S106-p 450916 DNQLTIKsPSKRELA protein stabilization; molecular association, regulation; intracellular localization cell cycle regulation CDH1(DISRUPTS) 10339564; 16153703; 19343071; 22179839 6 3 2 -Elk1 ELK1 DNA-binding; Transcription factor P41969 13712 X A1.3|X 16.45 cM mouse S390-p 449757 LSPIAPRsPAKLSFQ molecular association, regulation; intracellular localization cell differentiation, altered; transcription, induced; cytoskeletal reorganization; transcription, altered; cell growth, altered MED16(INDUCES); MED23(INDUCES); Trap100(INDUCES) DNA(INDUCES) 18160653; 18356083; 27738173; 35082159; 7889942 10 0 0 -Myocd myocardin Cell development/differentiation; Transcription factor Q8VIM5 214384 11|11 B3 mouse S624-p 3627505 GQTHVLSsTFLSPQC transcription, inhibited 16141410 1 0 0 -Vcpip1 VCIP135 Cell cycle regulation; DEUBIQUITINASE; EC 3.4.19.12; Protease; Ubiquitin conjugating system; Ubiquitin-specific protease Q8CF97 286761 5q11 rat S130-p 40642201 NYHCKLLsPILARYG VCIP135_N enzymatic activity, inhibited 25904330 1 3 0 regulates Golgi structure formation, attenuates golgi mrmbrane fusion -Erbb2 HER2 EC 2.7.10.1; KINASE; Kinase, protein; Membrane protein, integral; Oncoprotein; Protein kinase, TK; Protein kinase, tyrosine (receptor) P06494 24337 10q31 rat Y1114-p 448674 DLSPLQRySEDPTLP molecular association, regulation EGFR(INDUCES) 15163624 8 2 1 -DROSHA DROSHA EC 3.1.26.3; Nucleolus; RNA processing; RNA-binding; Ribonuclease Q9NRR4 29102 5p13.3 human S302-p 14572633 RDNRRSPsLERSYKK intracellular localization 20554852; 21674040 2 11 0 nuclear localization -GBA1 GBA EC 3.2.1.45; Glycan Metabolism - other glycan degradation; Hydrolase; Lipid Metabolism - sphingolipid P04062 2629 1q22 human K332-ub 1881371304 LLLPHWAkVVLTDPE protein degradation 34644545 1 1 0 K332R mutant has normal GBA activity; GBA impairment, a major cause in PD; premature degradation, and subsequent accumulation of alpha-synuclein -Abl1 Abl EC 2.7.10.2; KINASE; Kinase, protein; Oncoprotein; Protein kinase, TK; Protein kinase, tyrosine (non-receptor) P00520 11350 2 21.86 cM|2 B mouse Y232-p 450302 IYGVSPNyDKWEMER activity, induced 12149456 3 6 255 -Zbed3 ZBED3 DNA-binding Q9D0L1 72114 13|13 D1 mouse S111-p 6738702 MPCPPPPsPTMAAEG molecular association, regulation axin 1(INDUCES) 19141611 1 0 0 interaction beween ZBED3 and axin is important for ZBED3 to inhibit beta catenin (CTNNB1) phosphorylation by GSK3 beta ; activates Wnt signaling -L1CAM NCAM-L1 Cell adhesion; Membrane protein, integral P32004 3897 Xq28 human Y1176-p 456529 KDETFGEyRSLESDN Bravo_FIGEY molecular association, regulation; intracellular localization; phosphorylation cell adhesion, inhibited ANK3(INDUCES); AP2M1(NOT_REPORTED); AP2M1(DISRUPTS) 12082080; 19720049; 29109170; 9570805; 9651214 12 3 10 L1 sensitivity to ethanol -Sstr3 SSTR3 GPCR, family 1; Membrane protein, integral; Membrane protein, multi-pass; Receptor, GPCR P30936 171044 7q34 rat S346-p 456709 RPSRRVRsQEPGSGP receptor desensitization, altered; receptor internalization, altered 9295322 1 0 1 -ELK1 ELK1 DNA-binding; Transcription factor P19419 2002 Xp11.23 human S389-p 449757 LSPIAPRsPAKLSFQ activity, induced; protein conformation transcription, induced; transcription, altered 11145955; 8262053; 9130707 10 0 0 -Ripk1 RIPK1 EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, Ser/Thr (non-receptor); Protein kinase, TKL Q60855 19766 13 A3.3|13 14.01 cM mouse Y383-p 451864 KLQEEASyHAFGIFA molecular association, regulation; enzymatic activity, inhibited; phosphorylation apoptosis, inhibited MAPKAPK2(INDUCES) 36329033 1 9 290 induces MK2 phosphorylation -Jund JunD Motility/polarity/chemotaxis; Transcription factor P15066 16478 8 B3.3|8 34.15 cM mouse S90-p 473544 APDGLLAsPDLGLLK Jun transcription, altered 14676207 1 12 2 -IRS1 IRS1 Adaptor/scaffold; Motility/polarity/chemotaxis P35568 3667 2q36.3 human T525-p 27532989 DNRFRKRtHSAGTSP intracellular localization 34253290 1 3 0 disassociation of IRS2 from plasma membrane to cytosol; limits PM-associated PI3K and PIP3 synthesis -NANOG NANOG Cell development/differentiation; DNA-binding; Transcription factor Q9H9S0 79923 12p13.31 human T200-p 28070707 LPMWSNQtWNNSTWS protein stabilization; molecular association, regulation carcinogenesis, induced; cell motility, induced; cell growth, induced; transcription, induced; signaling pathway regulation p300(INDUCES); NANOG(INDUCES) DNA(INDUCES) 23708658; 30728896 3 1 0 5-Lox mediated signaling -HIF1A HIF1A Autophagy; DNA-binding; Transcription factor Q16665 3091 14q23.2 human S451-p 31877647 QNINLAMsPLPTAET protein stabilization; molecular association, regulation; ubiquitination carcinogenesis, induced; cell motility, induced; cell growth, induced; transcription, induced EGLN1(DISRUPTS); VHL(DISRUPTS); PIN1(INDUCES) 33550096 2 7 0 inhibits ubiquitination -MYC Myc DNA-binding; Nucleolus; Oncoprotein; Transcription factor P01106 4609 8q24.21 human S388-p 450961 RRNELKRsFFALRDQ HLH molecular association, regulation carcinogenesis, inhibited; cell growth, inhibited; cell differentiation, induced; transcription, induced MAX(DISRUPTS) DNA(INDUCES); DNA(DISRUPTS) 22020439; 25326649; 26678338 8 0 0 repression of YAP/TAZ activity -BAX BAX Apoptosis; Membrane protein, integral; Mitochondrial; Tumor suppressor Q07812 581 19q13.33 human S163-p 469571 GGWDGLLsYFGTPTW activity, induced; intracellular localization apoptosis, induced 15525785; 17911107 2 0 0 -TFEB TFEB DNA-binding; Transcription factor P19484 7942 6p21.1 human K274-ac 1878278901 DLDVRWNkGTILKAS molecular association, regulation autophagy, inhibited; transcription, inhibited TFEB(DISRUPTS) DNA(DISRUPTS) 31750630 1 0 0 suppresses TFEB transcriptional activity, knocking down dGcn5 in Drosophila eyes reduced hTau aggregation -ETV4 ETV4 DNA-binding P43268 2118 17q21.31 human Y392-p 5231710 KNRPAMNyDKLSRSL Ets intracellular localization cell motility, induced; transcription, induced 36670069 2 2 11 promotes lymph node metastasis of BCa cells -DACH1 DACH1 DNA-binding; Motility/polarity/chemotaxis; Transcription factor Q9UI36 1602 13q21.33 human S581-p 478242 EKDETPLsTPTARDS intracellular localization; activity, inhibited translation, inhibited 24335958 1 4 1 Repression of Snail 5' UTR-Luc reporter -Mapk1 ERK2 EC 2.7.11.24; KINASE; Kinase, protein; Protein kinase, CMGC; Protein kinase, Ser/Thr (non-receptor) P63086 116590 11q23 rat S27-p 7989100 GPRYTNLsYIGEGAY Pkinase molecular association, regulation; enzymatic activity, induced MEK2(INDUCES); MEK1(INDUCES) 19447520 1 0 0 -FBXL7 FBXL7 UBIQUITIN LIGASE; Ubiquitin ligase Q9UJT9 23194 5p15.1 human K109-ub 40320200 RLASRPQkEQASIDR protein degradation cell cycle regulation; apoptosis, inhibited 25654763 1 0 0 -Cavin1 PTRF Transcription initiation complex O54724 19285 11 D|11 63.95 cM mouse S368-p 452129 TDLLRGSsPDVHTLL phosphorylation 21282370 2 28 28 regulates phosphorylation of HSL S557 (aka S563) and S651 (aka S660); regulates lipolysis in adipocytes -GHR GH receptor Membrane protein, integral; Receptor, cytokine P19941 100009325 rabbit Y534-p 486256 NFIMDNAyFCEADAK GHBP molecular association, regulation STAT5A(INDUCES); STAT5B(INDUCES) 17666591 3 0 0 -Map1b MAP1B Cytoskeletal; Motility/polarity/chemotaxis P15205 29456 2q12 rat T2412-p 1172732404 WGSNMQVtLIPTHDS molecular association, regulation STX17(INDUCES) 29925525 1 0 0 starvation-induced dephosphorylation allows STX17 to dissociate from MAP1B and bind to ATG14 -GMNN Geminin Cell cycle regulation; Motility/polarity/chemotaxis O75496 51053 6p22.3 human K100-ub 964516696 NPSSQYWkEVAEKRR Geminin molecular association, regulation CDT1(DISRUPTS) 34599168 1 2 0 inhibits MCM proteins binding to Cdt1; cancer-derived SPOP mutants increase replication origin ?ring, re-replication, and genome instability, increased by ATR inhibition -XRCC5 Ku80 DNA-binding; EC 3.6.1.-; EC 3.6.4.-; Helicase; Nuclear receptor co-regulator; Nucleolus; RNA-binding P13010 7520 2q35 human K543-ub 12250514 LFPLIEAkKKDQVTA Ku_C molecular association, regulation DNA repair, induced DNA(DISRUPTS) 27895153 1 3 6 -CYP21A2 CYP21A2 EC 1.14.99.10; Lipid Metabolism - C21-steroid hormone; Oxidoreductase P08686 1589 6p21.33 human S490-p 1410340100 PRGMGAHsPGQSQ__ enzymatic activity, altered 30580688 1 1 0 Regulate steroidogenic enzyme activity -KIF2C KIF2C Cancer Testis Antigen (CTA); Microtubule-binding; Motility/polarity/chemotaxis; Motor Q99661 11004 1p34.1 human T537-p 14157500 LGQNKAHtPFRESKL Kinesin intracellular localization; activity, inhibited cell cycle regulation; cytoskeletal reorganization 20368358; 29230353 2 0 0 microtubule end does not accelerate ADP dissociation; reduced microtubule depolymerization activity and reduced microtubule-stimulated ATPase activity; abolishes long microtubule end residence events -TBK1 TBK1 EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, Other; Protein kinase, Ser/Thr (non-receptor) Q9UHD2 29110 12q14.2 human K372-ub 27492600 RLAQHFPkTTEENPI TBK1_ULD protein degradation 32366851 2 3 0 K48-linked polyubiquitination and degradation of TBK1 -CGAS cGAS EC 2.7.7.86 Q8N884 115004 6q13 human K384-ub 964506174 LSFSHIEkEILNNHG Mab-21 protein degradation autophagy, induced 36343628 1 2 0 -CTDP1 CTDP1 EC 3.1.3.16; Motility/polarity/chemotaxis; PHOSPHATASE; Protein phosphatase, Ser/Thr (non-receptor); Transcription initiation complex Q9Y5B0 9150 18q23 human S942-p 455466 SSNEDEGsSSEADEM FCP1_C molecular association, regulation; enzymatic activity, induced transcription, altered GTF2F1(INDUCES) 15723518; 19215094 2 0 1 -ARHGDIA RhoGDI alpha Apoptosis; Cell adhesion; Cell development/differentiation; G protein regulator, misc.; Motility/polarity/chemotaxis P52565 396 17q25.3 human K141-ac 461817 RKGVKIDkTDYMVGS Rho_GDI cytoskeletal reorganization 16916647 1 7 3 -APP APP iso4 Apoptosis; Cell surface; Membrane protein, integral; Receptor, misc.; Transcription factor P05067-4 351 21q21.3 human S206-p 450332 ADAEEDDsDVWWGGA intracellular localization 8999878 1 2 0 APP was phosphorylated within the post Golgi as well as on the cell surface. -NFATC4 NFAT3 DNA-binding; Transcription factor Q14934 4776 14q12 human S217-p 953803 GLGSPLPsPRASPRP transcription, induced 17875713 1 16 1 -KCNE3 KCNE3 Channel, potassium Q9Y6H6 10008 11q13.4 human S82-p 460569 LILGYTRsRKVDKRS ISK_Channel activity, induced; activity, inhibited 16449802; 21911611 2 0 0 KCNE3-S82A channels was not altered in the presence of E2; S82A rundown much more rapidly than the non-mutated channels; controls KCNE3-Kv3.4 channel opening -Acaca ACC1 Carbohydrate Metabolism - propanoate; Carbohydrate Metabolism - pyruvate; EC 6.3.4.14; EC 6.4.1.2; Ligase; Lipid Metabolism - fatty acid biosynthesis P11497 60581 10q26 rat S77-p 448291 LAFHMRSsMSGLHLV enzymatic activity, inhibited 7915280 8 4 0 -CLASP2 CLASP2 Cytoskeletal; Motility/polarity/chemotaxis O75122 23122 3p22.3 human S1053-p 14159685 DQFPDDLsLDHSDLV cell cycle regulation 23045552 1 3 0 -ACTB ACTB Cytoskeletal; Motility/polarity/chemotaxis P60709 60 7p22.1 human K50-ac 461691 VMVGMGQkDSYVGDE Actin molecular association, regulation CAP2(INDUCES); INF2(INDUCES) 31871199 2 5 58 acetyl-mimetic actin mutants inhibit INF2-mediated actin polimerization, CAP/Ac-actin binds INF2-DAD -DACH1 DACH1 DNA-binding; Motility/polarity/chemotaxis; Transcription factor Q9UI36 1602 13q21.33 human S493-p 4782166 ERVPDSPsPAPSLEE intracellular localization; activity, inhibited translation, inhibited 24335958 1 6 0 Repression of Snail 5' UTR-Luc reporter -TRIM32 TRIM32 EC 6.3.2.-; EC 6.3.2.19; Ligase; UBIQUITIN LIGASE; Ubiquitin conjugating system; Ubiquitin ligase Q13049 22954 9q33.1 human K50-ub 41497066 ICRQCLEkLLASSIN zf-RING_UBOX protein degradation; intracellular localization autophagy, induced 33999923 1 2 0 -Vamp2 VAMP2 Membrane protein, integral; Motility/polarity/chemotaxis; Vesicle P63044 22318 11|11 B3 mouse T35-p 12473004 SNRRLQQtQAQVDEV Synaptobrevin molecular association, regulation ATM(INDUCES) 19962314 1 0 0 complex of ATM, VAMP2, ATR and SYN1 -Dync1li2 DNCLI2 Motility/polarity/chemotaxis Q62698 81655 19p14 rat S194-p 452544 PEEGCQGsPQRRGPL DLIC cell cycle regulation; cytoskeletal reorganization 32467330 1 68 5 -Calm1 Calmodulin Calcium-binding; Protein phosphatase, regulatory subunit P0DP29 24242 6q32 rat Y100-p 448707 FDKDGNGyISAAELR EF-hand_7 activity, induced; protein stabilization 25830911 5 75 2115 -YAP1 YAP1 Oncoprotein; Transcription, coactivator/corepressor P46937 10413 11q22.1 human S94-p 3253276 RLRKLPDsFFKPPEP molecular association, regulation cell growth, induced; cell growth, inhibited; transcription, induced; transcription, inhibited TEAD1(DISRUPTS) 25751140; 27144834 8 3 3 -NANOG NANOG Cell development/differentiation; DNA-binding; Transcription factor Q9H9S0 79923 12p13.31 human Y35-p 25240301 ICGPEENyPSLQMSS activity, induced carcinogenesis, induced; cell motility, induced; cell growth, induced 22493428 1 0 0 increased lamellipodia and filopodia formation and increased cell polarization -HSPA9 HSPA9B Chaperone; Heat shock protein; Nucleolus P38646 3313 5q31.2 human T62-p 483967 VVGIDLGtTNSCVAV HSP70 protein stabilization 17573779 1 0 0 ; phosphorylation of this site stabilizes HSPA9B, activates TTK and promotes centrosome re-duplication -Rock2 ROCK2 EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, AGC; Protein kinase, Ser/Thr (non-receptor) Q62868 25537 6q16 rat Y722-p 464192 LADKNKIyESIEEAK enzymatic activity, inhibited 35889443 5 7 127 protects against hypoxia-reoxygenation (H/R) injury in response to hydrogen sulfide -CENPA CENPA DNA-binding P49450 1058 2p23.3 human K124-ub 40439801 GRVTLFPkDVQLARR Histone protein degradation; molecular association, regulation; ubiquitination; intracellular localization cell cycle regulation HJURP(INDUCES) 25727006; 31550462; 34758320 5 2 0 ubquitylation is required for viability, CENP-A K124R mutant is lethal, EYFP-CENP-A K124R induces additional ubiquitylation and binds HJURP. ; Ser68 facilitates degradation; induces CENPA localization/deposition at centromeres -Dab1 DAB1 Adaptor/scaffold P97318 13131 4 C6|4 47.79 cM mouse Y232-p 447961 SQKKEGVyDVPKSQP molecular association, regulation; intracellular localization neural plasticity; cell differentiation, induced; cell motility, altered; cell adhesion, altered; cytoskeletal reorganization Src(INDUCES); CRKL(INDUCES); SOCS1(INDUCES); NCK2(INDUCES); PIK3R1(INDUCES) 14517291; 15062102; 15091337; 19796633; 22586277 13 5 12 alternatively spliced variants -EIF4G1 eIF4G RNA-binding; Translation; Translation initiation Q04637 1981 3q27.1 human S1231-p 449798 EAALPPVsPLKAALS molecular association, regulation cell cycle regulation; translation, inhibited Mnk1(INDUCES); EIF4A1(INDUCES) RNA(DISRUPTS) 24248602 6 88 59 -GLI2 GLI2 C2H2-type zinc finger protein; Oncoprotein; Transcription factor P10070 2736 2q14.2 human S149-p 10414536 ISAARGLsPADVAQE molecular association, regulation; acetylation; intracellular localization carcinogenesis, induced; cell motility, induced; transcription, induced SNIP1(DISRUPTS) RNA(DISRUPTS) 25416949 1 4 0 CCL21 treatment, nuclear translocation -ADRB2 ADRB2 GPCR, family 1; Membrane protein, integral; Membrane protein, multi-pass; Receptor, GPCR P07550 154 5q32 human Y350-p 449808 RRSSLKAyGNGYSSN receptor internalization, induced 19864009 8 0 0 -XRCC5 Ku80 DNA-binding; EC 3.6.1.-; EC 3.6.4.-; Helicase; Nuclear receptor co-regulator; Nucleolus; RNA-binding P13010 7520 2q35 human K282-ub 15391475 TWTVVDAkTLKKEDI Ku molecular association, regulation DNA repair, induced DNA(DISRUPTS) 27895153 1 7 5 -PLK1 PLK1 EC 2.7.11.21; KINASE; Kinase, protein; Protein kinase, Other; Protein kinase, Ser/Thr (non-receptor) P53350 5347 16p12.2 human K492-ub 21181662 YMSEHLLkAGANITP molecular association, regulation; intracellular localization cell cycle regulation BUB1B(DISRUPTS); INCENP(DISRUPTS) 23455478 2 4 0 regulates PLK1 dissociation from kinetochores and anaphase onset -Dmbt1 DMBT1 Membrane protein, integral; Oncoprotein; Secreted; Secreted, signal peptide; Tumor suppressor Q60997 12945 7|7 F3 mouse T2073-p 13201902 AFTLGRRtHIDRGQP molecular association, regulation exocytosis, altered; cytoskeletal reorganization NHERF(INDUCES); ACTB(INDUCES) 15146979 1 0 0 Phosphomimetic peptides associate with the cytoskeleton, though not binding directly to actin. -SRSF2 SFRS2 RNA processing; RNA splicing; Spliceosome Q01130 6427 17q25.1 human K52-ac 20842100 IPRDRYTkESRGFAF RRM_1 protein degradation; ubiquitination cell cycle regulation; RNA splicing, inhibited; apoptosis, inhibited 21157427 1 1 0 inhibits ubiquitination, regulates SRPK1/SRPK32 localization inhibiting its phosphorylation and apoptosis -FBXO46 FBX46 UBIQUITIN LIGASE; Ubiquitin conjugating system; Ubiquitin ligase Q6PJ61 23403 19q13.32 human S67-p 1261736703 LATEVPAsQPAPLLS protein degradation 30171069 1 0 0 -Smad4 SMAD4 DNA-binding; Nuclear receptor co-regulator; Transcription, coactivator/corepressor P97471 17128 18 E2|18 49.51 cM mouse S342-p 15613801 GETFKVPsSCPVVTV MH2 protein stabilization; molecular association, regulation; enzymatic activity, induced apoptosis, induced; transcription, induced; signaling pathway regulation 29700281 2 0 0 increase MELK stability and activity; regulate ASK1/TGF-beta/p53 signaling pathways -CCAR1 CCAR1 Apoptosis; Nuclear receptor co-regulator; RNA splicing Q8IX12 55749 10q21.3 human Y192-p 460702 RVLVEATyNPNMPFK S1-like apoptosis, induced 16543231 1 1 0 -FOXA1 FOXA1 DNA-binding; Transcription factor P55317 3169 14q21.1 human K240-ac 11263050 RSPDKPGkGSYWTLH Forkhead molecular association, regulation chromatin organization, altered DNA(DISRUPTS) 19897491 1 0 0 -PYGO2 PYGO2 Cell development/differentiation; Histone-binding Q9BRQ0 90780 1q21.3 human S48-p 5965932 PEKKRRKsNTQGPAY protein stabilization 26170450 1 2 2 -IL6ST gp130 Membrane protein, integral; Receptor, cytokine P40189 3572 5q11.2 human Y814-p 450054 GILPRQQyFKQNCSQ cell cycle regulation; transcription, altered 10623831 3 0 1 -ATM ATM DNA repair, damage; EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, Ser/Thr (non-receptor); Protein kinase, atypical; Tumor suppressor Q13315 472 11q22.3 human T372-p 411189200 EISQSYTtTQRESSD enzymatic activity, inhibited; protein conformation cell cycle regulation; apoptosis, inhibited 27939942 1 0 0 -Nos1 nNOS Amino Acid Metabolism - arginine and proline; EC 1.14.13.39; Oxidoreductase P29476 24598 12q16 rat K739-ub 27201706 KKLAEAVkFSAKLMG protein degradation 23109339 1 2 0 -FOXO1 FOXO1A DNA-binding; Nuclear receptor co-regulator; Oncoprotein; Transcription factor Q12778 2308 13q14.11 human K274-ac 15625102 RSRAAKKkASLQSGQ intracellular localization; phosphorylation 20519497 4 0 0 -IQGAP1 IQGAP1 GAP; GAP, Ras; Motility/polarity/chemotaxis P46940 8826 15q26.1 human K1528-ub 12253471 GEQVDYYkSYIKTCL RasGAP_C molecular association, regulation CDC42(INDUCES); RAC1(INDUCES) 32094223 1 8 24 6KR mutant compared to WT -Mafb MAFB DNA-binding; Oncoprotein; Transcription factor; Tumor suppressor P54841 16658 2 H2|2 80.92 cM mouse K32-sm 12004404 DLLKFDVkKEPLGRA cell differentiation, inhibited; cell cycle regulation; cell growth, induced; transcription, inhibited 17548468 2 0 0 -PINK1 PINK1 EC 2.7.11.1; KINASE; Kinase, protein; Membrane protein, integral; Mitochondrial; Protein kinase, Other; Protein kinase, Ser/Thr (non-receptor) Q9BXM7 65018 1p36.12 human S402-p 25792201 GLQLPFSsWYVDRGG Pkinase ubiquitination; intracellular localization; protein conformation; phosphorylation; enzymatic activity, induced autophagy, induced 22910362; 23754282; 24189060; 25527497 5 1 0 PINK1 complex formation, Parkin recruitment onto depolarized mitochondria; mitophagy; T313A and S402A mutants interfere with PINK1 phosphorylation; regulate substrate phosphorylation, Parkin and Ubiquitin; promotes mitochondrial localization of parkin; Parkin recruitment; induce Ubiquitin-oxyester formation -Pparg PPAR-gamma DNA-binding; Nuclear receptor; Transcription factor P37238 19016 6 E3|6 53.41 cM mouse K293-ac 25780501 GEDKIKFkHITPLQE protein degradation; acetylation; molecular association, regulation N-CoR1(INDUCES); PRDM1(INDUCES) 22863012; 36394167 4 1 0 Impairs adipose plasticity During metabolic adaptions, mediates the diurnal cycle of adipose metabolism by destabilizing BMAL, rhythmicity in glucose tolerance and insulin sensitivity -ROCK1 ROCK1 EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, AGC; Protein kinase, Ser/Thr (non-receptor) Q13464 6093 18q11.1 human S1333-p 4935818 RASPRTLsTRSTANQ intracellular localization; enzymatic activity, induced cytoskeletal reorganization 21685893; 24168723 2 3 10 inhibits apical constriction -RAD17 RAD17 Cell cycle regulation O75943 5884 5q13.2 human T681-p 1868913302 EDYESDGt_______ molecular association, regulation; phosphorylation RAD1(INDUCES) 31353086 1 0 0 induces phosphorylation of other sites -DNMT1 DNMT1 Amino Acid Metabolism - cysteine and methionine; Cell development/differentiation; EC 2.1.1.37; METHYLTRANSFERASE; Methyltransferase; Methyltransferase, DNA; Transcription regulation P26358 1786 19p13.2 human K1054-ac 25171008 EEAVVDFkAVQGRCT BAH cell cycle regulation 21947282 1 1 0 -Hdac2 HDAC2 DEACETYLASE; Deacetylase; EC 3.5.1.98; Nuclear receptor co-regulator; Transcription, coactivator/corepressor P70288 15182 10 19.44 cM|10 B1 mouse S422-p 467979 IACDEEFsDSEDEGE enzymatic activity, induced 21576649 3 77 49 -IRS1 IRS1 Adaptor/scaffold; Motility/polarity/chemotaxis P35568 3667 2q36.3 human S1223-p 456047 SSSTRRSsEDLSAYA activity, inhibited SHP-2(DISRUPTS) 16020478 3 17 0 -GSTA4 GSTA4 EC 2.5.1.18; Other Amino Acids Metabolism - glutathione; Transferase; Xenobiotic Metabolism - drug metabolism - cytochrome P450; Xenobiotic Metabolism - metabolism by cytochrome P450 O15217 2941 6p12.2 human S189-p 455666 QEYTVKLsNIPTIKR GST_C_3 molecular association, regulation; intracellular localization HSP70(INDUCES) 12646569 1 0 0 -Mapk14 P38A EC 2.7.11.24; KINASE; Kinase, protein; Protein kinase, CMGC; Protein kinase, Ser/Thr (non-receptor) P47811 26416 17 A3.3|17 14.85 cM mouse T180-p 447970 RHTDDEMtGYVATRW Pkinase molecular association, regulation; phosphorylation; enzymatic activity, induced cell cycle regulation; carcinogenesis, inhibited; cell growth, inhibited; apoptosis, induced; cell motility, inhibited; transcription, induced; signaling pathway regulation; transcription, altered; cell growth, induced PKCZ(INDUCES) 10867029; 12032135; 15665819; 15975986; 16648139; 18669639; 19324872; 21847090; 25098293; 26517532; 34560245; 35112724; 35637461; 36310322; 36642184 401 73 1542 -Mapt Tau ACETYLTRANSFERASE; Acetyltransferase; Cytoskeletal P19332 29477 10q32.1 rat S510-p 447927 GERSGYSsPGSPGTP molecular association, regulation; protein conformation neural plasticity PPP1CC(INDUCES) 33519375; 36859689 91 33 33 -KCND1 KCND1 Membrane protein, integral; Membrane protein, multi-pass Q9NSA2 3750 Xp11.23 human S555-p 4714921 TASVSRGsMQELDML intracellular localization neural plasticity 34234278 1 4 0 -SNAI2 Snail2 Apoptosis; C2H2-type zinc finger protein; Motility/polarity/chemotaxis; Transcription factor O43623 6591 8q11.21 human S254-p 63243402 SKTFSRMsLLHKHEE zf-C2H2 activity, induced; protein stabilization; ubiquitination; intracellular localization carcinogenesis, induced; transcription, inhibited 29849120 3 0 0 induces transcriptional repressor activity, inhibits ubiquitination -PTPN18 BDP1 EC 3.1.3.48; Motility/polarity/chemotaxis; PHOSPHATASE; Protein phosphatase, tyrosine (non-receptor) Q99952 26469 2q21.1 human Y389-p 449000 SAEEAPLySKVTPRA molecular association, regulation TEC(INDUCES); SH2D1B(NOT_REPORTED); Arg(NOT_REPORTED) 14679216; 23322602 1 28 655 -Cebpb C/EBP-beta DNA-binding; Motility/polarity/chemotaxis; Transcription factor P21272 24253 3q42 rat K39-ac 473550 DCLAYGAkAARAAPR molecular association, regulation transcription, induced DNA(INDUCES) 24344329 4 0 0 -STAT3 STAT3 DNA-binding; Motility/polarity/chemotaxis; Nuclear receptor co-regulator; Transcription factor P40763 6774 17q21.2 human R688-me 1883327701 EAFGKYCrPESQEHP carcinogenesis, induced; cell motility, induced; transcription, induced 36151091 1 1 0 osteosarcoma cell migration, invasion and metastasis -SRC Src EC 2.7.10.2; KINASE; Kinase, protein; Oncoprotein; Protein kinase, TK; Protein kinase, tyrosine (non-receptor) P00523 396442 chicken S17-p 448231 DPSQRRRsLEPPDST phosphorylation cell growth, altered 2474754; 2582236 10 46 12 -TTK TTK Cancer Testis Antigen (CTA); EC 2.7.12.1; KINASE; Kinase, protein; Protein kinase, Other; Protein kinase, dual-specificity (non-receptor) P33981 7272 6q14.1 human T594-p 41389700 RLYDYEItDQYIYMV Pkinase intracellular localization; enzymatic activity, induced 26119734 1 0 0 regulates spindle assembly checkpoint and recruitment of SAC proteins -DCLRE1C Artemis DNA repair, damage; Deoxyribonuclease; EC 3.1.-.- Q96SD1 64421 10p13 human S649-p 38410201 NADSQSSsDFEVPST molecular association, regulation; intracellular localization DNA repair, induced PAXIP1(INDUCES) 25512557 1 1 0 Artemis prevents end resection and promotes non-homologous end joining -NR3C1 GR DNA-binding; Mitochondrial; Nuclear receptor; Transcription factor P04150 2908 5q31.3 human T562-p 1872513501 STWRIMTtLNMLGGR Hormone_recep molecular association, regulation 14-3-3 zeta(INDUCES) 33744286 1 1 0 -Cacna1c CACNA1C Channel, calcium; Membrane protein, integral; Membrane protein, multi-pass P22002 24239 4q42 rat S1699-p 4714250 PEIRRAIsGDLTAEE CAC1F_C intracellular localization 29180451 17 7 0 membrane expression and distribution of CACNA1C along the dendrites of hippocampal neurons; differentially regulates the surface traffic of CACNA1C -CHEK2 Chk2 EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, CAMK; Protein kinase, Ser/Thr (non-receptor); Tumor suppressor O96017 11200 22q12.1 human S28-p 447548 PHGSVTQsQGSSSQS phosphorylation; enzymatic activity, induced 12024051 3 0 0 -GYS1 GYS1 Carbohydrate Metabolism - starch and sucrose; EC 2.4.1.11; Transferase P13807 2997 19q13.33 human S641-p 448237 YRYPRPAsVPPSPSL Glycogen_syn enzymatic activity, inhibited; activity, inhibited signaling pathway regulation 19339242; 21668450; 22510711; 29541418 38 28 2 regulation of glycogen synthesis via R3F-PP1 signaling in astrocytoma cells -PIK3R1 PIK3R1 KINASE; Kinase, lipid; Motility/polarity/chemotaxis P23727 282307 cow S608-p 448133 ENTEDQYsLVEDDED enzymatic activity, inhibited 8313897 3 3 24 phosphorylation causes a decrease in PI3K activity. -Grin2b NMDAR2B Channel, calcium; Channel, ligand-gated; Membrane protein, integral; Membrane protein, multi-pass Q01097 14812 6 G1|6 66.38 cM mouse Y1472-p 448167 GSSNGHVyEKLSSIE NMDAR2_C activity, induced; receptor desensitization, altered; receptor internalization, altered; intracellular localization; phosphorylation neural plasticity; cell adhesion, induced; signaling pathway regulation 16190898; 16710293; 20427654; 26279570; 30916039; 33975959; 34433031; 34679709; 35536885 42 1 104 -ARAF ARAF EC 2.7.11.1; KINASE; Kinase, protein; Oncoprotein; Protein kinase, Ser/Thr (non-receptor); Protein kinase, TKL P10398 369 Xp11.3 human T452-p 3306308 IGDFGLAtVKTRWSG PK_Tyr_Ser-Thr enzymatic activity, induced 18662992 0 1 0 -TAB2 TAB2 Adaptor/scaffold Q9NYJ8 23118 6q25.1 human S419-p 456006 NSGASAAsRNMSGQV molecular association, regulation; intracellular localization ER-alpha(INDUCES) 12150997; 27992601 2 0 0 -TNFAIP3 TNFAIP3 Apoptosis; DEUBIQUITINASE; EC 3.4.19.12; Protease; UBIQUITIN LIGASE; Ubiquitin conjugating system; Ubiquitin ligase P21580 7128 6q23.3 human S480-p 31859341 TTAMKCRsPGCPFTL zf-A20 ubiquitination 26649818 1 2 0 cleavage of K63-linked tetraubiquitin ( all 4 sites or S381 alone), enhances ZnF4-mediated substrate ubiquitination -Nup210 NUP210 Membrane protein, integral; Nucleoporin P11654 58958 4q34 rat S1880-p 482838 SPPSGLWsPAYASH_ molecular association, regulation; intracellular localization 17559836 2 13 1 regulation of binding and recruitment of NUP210 to nuclear pore complex; Mitotic phosphorylation dissociates NUP210 from the NPC. -Cd274 PD-L1 Membrane protein, integral Q9EP73 60533 19|19 C1 mouse K262-ac 1875250200 TVLLFLRkQVRMLDV intracellular localization transcription, inhibited KPNA1(DISRUPTS); HIP1R(DISRUPTS) 32839551 1 1 0 nuclear localization that governs immune-response gene expression -OCLN occludin Cell adhesion; Membrane protein, integral; Membrane protein, multi-pass; Motility/polarity/chemotaxis Q16625 100506658 5q13.2 human T438-p 19083405 LYKRNFDtGLQEYKS Occludin_ELL intracellular localization 21545357 1 0 0 facilitates assembly of occludin into tight junction -DGCR8 DGCR8 Nucleolus; RNA processing; RNA-binding Q8WYQ5 54487 22q11.21 human S109-p 3208074 APAVRKFsPDLKLLK protein stabilization 24239349 0 16 0 -THOC5 FMIP Cell development/differentiation; RNA splicing; Spliceosome Q13769 8563 22q12.2 human Y225-p 25802102 EIEVKKEyLSSLQPR FmiP_Thoc5 molecular association, regulation; intracellular localization translation, altered; cell motility, altered; signaling pathway regulation RNA(INDUCES) 23032722; 26919114 2 1 0 cytosolic localization, chemokinesis -Il21r IL21R Membrane protein, integral; Receptor, cytokine Q9JHX3 60504 7|7 F3 mouse Y319-p 1270906 SALHLSLyPAKEKKF cell growth, altered 17234735 1 0 0 -MYOM2 myomesin 2 Contractile; Cytoskeletal P54296 9172 8p23.3 human S76-p 466426 RVCAKRVsTQEDEEQ molecular association, regulation cytoskeletal reorganization MYH1(INDUCES) 9529381 1 5 1 binding of myomesin 2 adjacent to the amino-terminal domain Mp1, to myosin rod (MYH1) -SLA SLAP Adaptor/scaffold Q13239 6503 8q24.22 human Y273-p 467049 SFFSSPPyFED____ activity, inhibited 24284075 1 2 5 oncogenic c-Kit bypasses the normal cellular negative feedback control -LRRK2 LRRK2 EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, Ser/Thr (non-receptor); Protein kinase, TKL Q5S007 120892 12q12 human S973-p 4725913 SHMRHSDsISSLASE protein stabilization; ubiquitination; enzymatic activity, inhibited; phosphorylation 25009464; 34144124 14 13 0 induces dephosphorylation at autophosphorylation sites; inhibits ubiquitination -ANXA1 ANXA1 Calcium-binding; Lipid-binding P04083 301 9q21.13 human Y21-p 447974 IENEEQEyVQTVKSS intracellular localization 16052208 5 16 171 EGF-stimulated increase in inward vesiculation is abolished in ANXA1 knockout cells, and rescued by WT but not by Y21F mutant ANXA1. -Crtc2 TORC2 Transcription, coactivator/corepressor Q3U182 74343 3|3 F1 mouse K628-ac 486389 DSSPGFSkEIAAALA TORC_C activity, induced; protein degradation; molecular association, regulation; ubiquitination transcription, induced p300(INDUCES) 18849969 1 0 0 -AMPH amphiphysin Vesicle P49418 273 7p14.1 human S654-p 1877626500 DVVLVVPsDSEADQD SH3_9 neural plasticity; apoptosis, inhibited 35858575 1 1 0 -POLH POLH DNA repair, damage; EC 2.7.7.7; Transferase Q9Y253 5429 6p21.1 human K475-sm 1877365907 PAVTATKkATTSLES intracellular localization; enzymatic activity, inhibited 32350109 1 1 0 -Slc12a5 KCC2 Membrane protein, integral; Membrane protein, multi-pass; Transporter; Transporter, SLC family Q63633 171373 3q42 rat Y1110-p 3087801 NRNGDENyMEFLEVL SLC12 activity, induced; protein degradation; molecular association, regulation; intracellular localization KCC2(INDUCES) 19679663; 20600929 3 0 0 decreases the cell surface stability of SLC12A5 (aka KCC2) -PPP2CA PPP2CA EC 3.1.3.16; Motility/polarity/chemotaxis; PHOSPHATASE; Protein phosphatase, Ser/Thr (non-receptor) P67775 5515 5q31.1 human Y127-p 4251175 SRQITQVyGFYDECL Metallophos phosphorylation 35820485 1 1 0 induces ERK and Tau phosphorylation -OPRM1 MOR-1 GPCR, family 1; Membrane protein, integral; Membrane protein, multi-pass; Receptor, GPCR P35372 4988 6q25.2 human S268-p 447782 LKSVRMLsGSKEKDR 7tm_1 receptor desensitization, altered 10908300 3 0 2 -EGR1 EGR1 C2H2-type zinc finger protein; DNA-binding; Transcription factor P18146 1958 5q31.2 human S26-p 458492 PFGSFPHsPTMDNYP cell motility, induced; cell growth, induced; apoptosis, inhibited; transcription, induced 34476983; 35041980 3 2 7 -TNC TNC Motility/polarity/chemotaxis; Secreted; Secreted, signal peptide P24821 3371 9q33.1 human K942-ub 1877447400 HAEVDVPkSQQATTK fn3 protein degradation autophagy, induced 32732922 1 1 0 defective autophagy is key immunosuppressive factor in TNBC tumours -Mpl MPL Membrane protein, integral; Receptor, cytokine Q08351 17480 4 D2.1|4 54.61 cM mouse S566-p 3091406 LEILPKSsESTPLPL activity, induced; phosphorylation cell growth, altered 10918061 1 0 0 tyrosine phosphorylation of JAK2 -HIPK2 HIPK2 EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, CMGC; Protein kinase, Ser/Thr (non-receptor) Q9H2X6 28996 7q34 human K1191-sm 2407407 GYPLSPAkVNQYPYI intracellular localization 10535925 1 0 0 localization to the nuclear speckles (dots) -SRSF1 SF2 RNA splicing; RNA-binding; Spliceosome Q07955 6426 17q22 human S209-p 2303911 YGRSRSRsRSRSRSR protein conformation 24449914 2 0 0 RS domain adopts an extended conformation -Dhx33 DHX33 EC 3.6.4.13; Helicase; Nucleolus Q80VY9 216877 11|11 B4 mouse T482-p 1883375203 KDDQLTLtPIGRKMA protein degradation 36403931 1 0 0 -Cd200r1 CD200R Membrane protein, integral; Receptor, misc. Q9ES57 57781 16|16 B4 mouse Y297-p 458379 TEKSNPLyDTVTKVE molecular association, regulation DOK2(INDUCES); DOK1(INDUCES) 16330532 2 2 11 -POLH POLH DNA repair, damage; EC 2.7.7.7; Transferase Q9Y253 5429 6p21.1 human K131-sm 1877365908 AVQERLQkLQGQPIS IMS intracellular localization; enzymatic activity, inhibited 32350109 1 1 0 -UPF1 RENT1 C2H2-type zinc finger protein; EC 3.6.1.-; EC 3.6.4.-; Hydrolase; RNA-binding Q92900 5976 19p13.11 human T28-p 21560213 AELLGADtQGSEFEF molecular association, regulation RNA stability, inhibited EST1A(INDUCES) 21965535 3 0 0 important for NMD (nonsense-mediated mRNA decay) -MYL2 MRLC2V Contractile P10916 4633 12q24.11 human S15-p 2846506 KRAGGANsNVFSMFE cell cycle regulation; carcinogenesis, induced; cell growth, induced 25412762 7 7 15 regulates cytokinesis -PTK2 FAK EC 2.7.10.2; KINASE; Kinase, protein; Protein kinase, TK; Protein kinase, tyrosine (non-receptor) Q00944 396416 chicken S726-p 1320900 GYPSPRSsEGFYPSP phosphorylation 15975092 1 0 1 primes for the GSK3-beta phosphorylation of S722 -HNF4A HNF4 alpha DNA-binding; Nuclear receptor; Transcription factor P41235 3172 20q13.12 human K458-ac 25336501 GAVATIVkPLSAIPQ protein degradation transcription, inhibited 21708125; 33636024 2 2 0 -ERBB4 HER4 EC 2.7.10.1; KINASE; Kinase, protein; Membrane protein, integral; Protein kinase, TK; Protein kinase, tyrosine (receptor) Q15303 2066 2q34 human Y1208-p 4825109 EYVNEPLyLNTFANT molecular association, regulation GRB2(INDUCES) 16729043 1 1 1 -CTNNB1 CTNNB1 Actin-binding; Cell adhesion; Motility/polarity/chemotaxis; Nuclear receptor co-regulator; Oncoprotein; Transcription factor P35222 1499 3p22.1 human K354-ac 27581500 LSVCSSNkPAIVEAG Arm molecular association, regulation; intracellular localization transcription, induced LEF-1(INDUCES) 23273980 2 0 0 -Stat3 STAT3 DNA-binding; Motility/polarity/chemotaxis; Nuclear receptor co-regulator; Transcription factor P52631 25125 10q31 rat Y705-p 448192 DPGSAAPyLKTKFIC activity, induced; protein stabilization; molecular association, regulation; intracellular localization cell differentiation, altered; apoptosis, altered; cell growth, induced; transcription, induced; signaling pathway regulation; transcription, altered SRC-1(INDUCES); CBP(INDUCES) 11922392; 12595539; 15860735; 16048438; 18230613; 19109898; 19427337; 33628191; 33781742 541 75 3065 induces YAP1 stabilization, induces S1PR2/STAT3/miR-135b/?-transduction repeat-containing protein/YAP/Notch3 pathway; induces neuroinflammation -SAFB2 SAFB2 Nuclear receptor co-regulator; RNA-binding Q14151 9667 19p13.3 human K225-m1 58123005 DILGETCkSEPVKEE molecular association, regulation L3MBTL iso4(INDUCES) 23583077 0 1 0 -Hcn4 HCN4 Channel, cation; Membrane protein, integral; Membrane protein, multi-pass O70507 330953 9|9 B mouse S1140-p 4699517 TLPRKTSsGSLPPPL activity, induced 20713547 1 0 0 required for PKA to shift the voltage dependence of HCN4 -Gja4 GJA4 Cell adhesion; Membrane protein, integral; Membrane protein, multi-pass P28235 14612 4 D2.2|4 61.47 cM mouse S319-p 3243300 APQGGRKsPSRPNSS molecular association, regulation; protein conformation cell cycle regulation; cell growth, inhibited GJA4(INDUCES) 32350069 2 2 0 regulation of intramolecular interaction -PREX1 PREX1 GEF; GEF, Rac/Rho Q8TCU6 57580 20q13.13 human S313-p 18704701 RVTGSKKsTKRTKSI activity, induced; activity, inhibited 21042280; 27788493 2 0 0 dephosphorylation of serines 313 and 319 negatively regulate GEF activity -Gpm6a GPM6A Cell surface; Channel, calcium; Membrane protein, integral; Membrane protein, multi-pass Q812E9 306439 16p11 rat S267-p 456834 QELHDIHsTRSKERL activity, induced 12359212 1 8 1 -Jund JunD Motility/polarity/chemotaxis; Transcription factor P15066 16478 8 B3.3|8 34.15 cM mouse S100-p 456168 LGLLKLAsPELERLI Jun transcription, altered 14676207 5 63 12 -Trpv4 TRPV4 Channel, cation; Membrane protein, integral; Membrane protein, multi-pass Q9EPK8 63873 5|5 F mouse Y253-p 448752 IERRCKHyVELLVAQ Ank activity, induced 12538589 1 0 0 -STX4 STX4 Membrane protein, integral; Vesicle Q12846 6810 16p11.2 human S78-p 1172732400 ATPLPEEsMKQELQN Syntaxin protein degradation; ubiquitination 29896202 1 0 0 induce resistance of tumor cells to Cisplatin -PAX8 PAX8 Transcription factor Q06710 7849 2q14.1 human K275-ub 1877752104 NSTLDDGkATLTPSN protein degradation; ubiquitination 31391550 1 0 0 -TRAPPC6A TRAPPC6A O75865 79090 19q13.32 human Y112-p 40253302 PMASGLQyLEEAPKF TRAPP intracellular localization; protein conformation apoptosis, induced 25650666; 27551439 2 0 0 Mutant proteins do not cause aggregation or caspase activation. ; protein aggregation, Ser35 phosphorylation is essential for relocation of TPC6A to the nucleolus and pTyr112 needed for relocation to the cytoplasm -H2ac1 H2A.4 DNA-binding Q8CGP4 319163 13|13 A3.1 mouse K119-ub 10836014 QAVLLPKkTESHKSQ Histone_H2A_C transcription, inhibited 34608337 1 2 130 PRC1 mediated repression is achieved by controlling transcriptional burst frequency -AKT1 Akt1 EC 2.7.11.1; KINASE; Kinase, protein; Oncoprotein; Protein kinase, AGC; Protein kinase, Ser/Thr (non-receptor) P31749 207 14q32.33 human S473-p 447855 RPHFPQFsYSASGTA Pkinase_C protein degradation; molecular association, regulation; enzymatic activity, inhibited; phosphorylation; enzymatic activity, induced; activity, induced; sumoylation; ubiquitination; intracellular localization; protein conformation cell cycle regulation; carcinogenesis, induced; apoptosis, altered; apoptosis, induced; cell motility, induced; cell motility, inhibited; signaling pathway regulation; cell differentiation, altered; cell growth, induced; cell motility, altered; autophagy, altered; DNA repair, inhibited; translation, induced; transcription, inhibited; cell growth, altered; cell differentiation, inhibited; carcinogenesis, inhibited; carcinogenesis, altered; cell growth, inhibited; transcription, induced; transcription, altered; autophagy, induced; cell differentiation, induced; apoptosis, inhibited; autophagy, inhibited; cytoskeletal reorganization; translation, inhibited NPM1(INDUCES); Sin1(INDUCES); PDK1(INDUCES); PAK1(INDUCES); PPP2CA(INDUCES); ILK(INDUCES); RICTOR(INDUCES); TGFBR3(INDUCES); TRAF6(INDUCES); PIK3R1(INDUCES) 10377409; 10400692; 10827191; 10926925; 10958682; 10973320; 11319202; 11358816; 11375271; 11389054; 11402048; 11577096; 11809760; 11978735; 12101233; 12149249; 12556562; 12642872; 12649200; 12686550; 12917346; 12970779; 14623889; 14713298; 14990993; 15028555; 15065872; 15327518; 15504738; 15546863; 15755769; 15781651; 15782140; 15808505; 16043647; 16044149; 16926151; 17386267; 17545609; 17586693; 18042541; 18209096; 18339839; 18678787; 18718903; 18931307; 18931661; 18957207; 19036927; 19574224; 19609947; 19797085; 19996208; 20008839; 20042122; 20085797; 20153512; 20228268; 20371716; 21057531; 21159648; 21177249; 21308747; 21329883; 21454539; 21530327; 21602434; 21743495; 21750219; 21775285; 21795477; 21908613; 21908616; 21980390; 22071574; 22080480; 22139837; 22580611; 23142783; 23188060; 23376850; 23644655; 23901139; 24297901; 24396487; 24446434; 24469056; 24632852; 24634221; 24670654; 25071014; 25100728; 25361894; 25745998; 25867063; 26411369; 26536663; 27197158; 28462918; 28676490; 29088759; 30413706; 31182807; 31679687; 31933886; 31978707; 32005974; 32081857; 32085396; 32101748; 32188912; 33407730; 33477794; 33574930; 33579227; 33592378; 33661942; 33664452; 33723214; 33727226; 33730574; 33741342; 33744230; 33753495; 33755959; 33767437; 33793628; 33835469; 33836561; 33845796; 33874915; 33890983; 33927349; 33941854; 33958720; 33984593; 33995548; 34021259; 34065746; 34073781; 34077419; 34078530; 34087103; 34132782; 34194551; 34208786; 34226680; 34237099; 34301793; 34326276; 34348155; 34380633; 34381564; 34383763; 34385295; 34385319; 34405859; 34418433; 34437633; 34465724; 34503444; 34523696; 34551282; 34588619; 34611309; 34639123; 34642304; 34675073; 34675258; 34686341; 34762647; 34780466; 34785213; 34785642; 34909046; 34921839; 34938598; 34948236; 34966427; 34973338; 34982576; 34995286; 35061720; 35070988; 35090553; 35126712; 35190555; 35201262; 35214753; 35250564; 35279705; 35347116; 35366279; 35367211; 35413055; 35545051; 35564180; 35577075; 35670054; 35773668; 35810308; 35835217; 35841593; 35864174; 35884549; 35907820; 35918763; 35962191; 35998013; 36053753; 36079767; 36139911; 36149602; 36174454; 36216931; 36269753; 36314765; 36348350; 36357572; 36413544; 36418288; 36471885; 36480552; 36509141; 36520954; 36525420; 36635496; 36640312; 36646789; 36652560; 36715448; 36724120; 36787291; 36822326; 37056386; 37078777; 37083591; 37324940; 37363966; 37430297; 37507012; 8978681; 9445477; 9690513 1956 25 44 -Lat2 LAB Adaptor/scaffold; Membrane protein, integral Q9JHL0 56743 5|5 G2 mouse Y98-p 455006 EGPESPRyQNFYKGS LAT2 signaling pathway regulation 22308309 2 2 4 plays a negative role in TCR and FcRI-mediated and no role in LPS-mediated signaling -SNRNP70 snRNP 70 RNA splicing; RNA-binding; Spliceosome P08621 6625 19q13.33 human S226-p 451900 YDERPGPsPLPHRDR molecular association, regulation; intracellular localization; protein conformation RNA splicing, induced SF2(INDUCES); snRNP A(INDUCES); snRNP B1(INDUCES); snRNP C(INDUCES); SMN(INDUCES) 33811140 2 87 8 -Map3k12 DLK EC 2.7.11.25; KINASE; Kinase, protein; Protein kinase, Ser/Thr (non-receptor); Protein kinase, TKL Q60700 26404 15|15 F3 mouse T659-p 40416400 GARGRGAtGGARDPG enzymatic activity, inhibited cell growth, induced 25802931 1 0 0 S584A T659A mutants have inhibited growth and increased kinase activity -USP24 USP24 DEUBIQUITINASE; EC 3.4.19.12; Protease; Ubiquitin-specific protease Q9UPU5 23358 1p32.3 human S2604-p 3216276 HLQQGSEsPMMIGEL protein degradation cell cycle regulation 27991932 1 23 1 -ARRB1 ARRB1 Adaptor/scaffold P49407 408 11q13.4 human S412-p 447493 EEEDGTGsPQLNNR_ activity, induced; molecular association, regulation; intracellular localization; activity, inhibited ADRB2(DISRUPTS); MEKK1(INDUCES) 10347142; 15456867; 19014372; 19153083 8 46 1 -SCN5A SCN5A Channel, sodium; Membrane protein, integral; Membrane protein, multi-pass Q14524 6331 3p22.2 human S1985-p 235474402 DSVTRATsDNLQVRG activity, induced; molecular association, regulation FGF13(DISRUPTS); Calmodulin(DISRUPTS) 28882890 2 2 0 impairs FGF13-dependent regulation of NaV1.5 channel inactivation -CLOCK CLOCK ACETYLTRANSFERASE; Acetyltransferase; DNA-binding; EC 2.3.1.48; Transcription factor O15516 9575 4q12 human T451-p 30259800 AVSDPSStPTKIPTD intracellular localization transcription, induced 24235147 1 1 0 regulate nuclear/cytoplasmic localization, Cdk5-mediated increased CLOCK transcription -PHLPP1 PHLPP EC 3.1.3.16; PHOSPHATASE; Protein phosphatase, Ser/Thr (non-receptor); Tumor suppressor O60346 23239 18q21.33 human S321-p 31863286 RRASPAPsDSSPGEP cell cycle regulation 33397691 1 2 0 -HSPA5 GRP78 Chaperone; Heat shock protein; KINASE P11021 3309 9q33.3 human K125-ac 13362601 KVVEKKTkPYIQVDI HSP70 molecular association, regulation; phosphorylation apoptosis, induced; signaling pathway regulation PERK(DISRUPTS) 20371724 1 2 0 induces phosphorylation of elf2a and activation of eIf2a-ATF4-CHOP pathway -PLN PLB Inhibitor; Membrane protein, integral P61012 414755 dog S16-p 448114 RSAIRRAsTIEMPQQ Phospholamban molecular association, regulation SERCA2(DISRUPTS) 17548345 78 15 66 -SND1 SND1 RNA-binding; Transcription, coactivator/corepressor Q7KZF4 27044 7q32.1 human T429-p 3203811 IRPASPAtETVPAFS SNase cell cycle regulation; transcription, induced 25627688 1 1 0 gene transcriptional activation of cyclin A and E2F-1 -AHCYL1 AHCYL1 Amino Acid Metabolism - cysteine and methionine; EC 3.3.1.1; Hydrolase; Other Amino Acids Metabolism - selenoamino acid O43865 10768 1p13.3 human S68-p 467244 RSLSRSIsQSSTDSY molecular association, regulation NHERF(INDUCES); NHE3(INDUCES) 27279487 6 1 1 -DGCR8 DGCR8 Nucleolus; RNA processing; RNA-binding Q8WYQ5 54487 22q11.21 human T371-p 18909948 REQSSDLtPSGDVSP protein stabilization 24239349 1 7 4 -BRAF BRAF EC 2.7.11.1; KINASE; Kinase, protein; Oncoprotein; Protein kinase, Ser/Thr (non-receptor); Protein kinase, TKL P15056 673 7q34 human S602-p 447805 FGLATVKsRWSGSHQ PK_Tyr_Ser-Thr molecular association, regulation; protein conformation; enzymatic activity, induced carcinogenesis, induced; cell differentiation, altered; cell growth, induced; transcription, induced; transcription, altered; cell growth, altered BRAF(NOT_REPORTED) 11032810; 11293329; 15710605; 18451171; 23907581; 26657898 11 0 0 phosphorylation at T599 and S602 and K578 ubiquitination mediate ERK activation -HEXIM1 HEXIM1 Motility/polarity/chemotaxis; Transcription factor O94992 10614 17q21.31 human K284-ub 9805702 ESLQNMSkQELIKEY HEXIM transcription, inhibited 19617712 1 1 0 -DNM1L DRP1 Apoptosis; EC 3.6.5.5; Endoplasmic reticulum; Hydrolase; Microtubule-binding; Mitochondrial; Motor O00429 10059 12p11.21 human S44-p 31866197 GKSSVLEsLVGRDLL Dynamin_N intracellular localization; phosphorylation; enzymatic activity, induced apoptosis, induced 25192600 2 1 0 mitochondrial localization, increased GTPase activity, mitochondrial fragmentation ; S44 serves as a priming site for S40 phosphorylation -Oprl1 KOR-3 GPCR, family 1; Membrane protein, integral; Membrane protein, multi-pass; Receptor, GPCR P35370 29256 3q43 rat S335-p 456133 RKFCCASsLHREMQV activity, induced; receptor desensitization, altered 16019191 1 0 0 -VCP VCP Chaperone; DNA repair, damage; EC 3.6.4.6; Endoplasmic reticulum; Hydrolase P55072 7415 9p13.3 human T761-p 3653838 KYEMFAQtLQQSRGF Vps4_C enzymatic activity, induced 19335618 1 2 0 -Cacng2 Stargazin Channel, calcium; Membrane protein, integral; Membrane protein, multi-pass O88602 12300 15 E1|15 36.92 cM mouse S243-p 455318 RSRSSSRsTEPSHSR activity, induced; intracellular localization 15664178; 20670832 3 0 0 AMPAR immobilization in synaptic membrane; enhances AMPA receptor responses and is required for long-term potentiation -Ryr2 RYR2 Channel, ligand-gated; Membrane protein, integral; Membrane protein, multi-pass; Transporter; Transporter, ion channel E9Q401 20191 13 A1|13 4.38 cM mouse G1885-p 2535900 GEEEAKGgKRPKEGL activity, induced 18326664 1 0 0 nearly abolished Ca2+ release activity in G1885E/G1886S mutant -VCP VCP Chaperone; DNA repair, damage; EC 3.6.4.6; Endoplasmic reticulum; Hydrolase P55072 7415 9p13.3 human K696-ac 7435507 EICQRACkLAIRESI AAA_lid_3 enzymatic activity, induced 19335618 1 1 4 -NPHP1 NPHP1 Cell adhesion O15259 4867 2q13 human Y46-p 18449508 PNKRQHIyQRCIQLK molecular association, regulation; intracellular localization PACS-1(INDUCES) 21357692 1 0 0 -IRS2 IRS2 Adaptor/scaffold; Motility/polarity/chemotaxis Q9Y4H2 8660 13q34 human S365-p 483509 SCRVRTAsEGDGGAA activity, inhibited 34731634 1 30 37 -PTPN1 PTP1B EC 3.1.3.48; Motility/polarity/chemotaxis; PHOSPHATASE; Phosphatase; Protein phosphatase, tyrosine (non-receptor) P18031 5770 20q13.13 human Y46-p 3791168 KNKNRNRyRDVSPFD Y_phosphatase molecular association, regulation; enzymatic activity, altered; phosphorylation INSR(DISRUPTS) 21487008; 31177093 2 0 66 -CGAS cGAS EC 2.7.7.86 Q8N884 115004 6q13 human K231-sm 59117703 NEFDVMFkLEVPRIQ Mab-21 protein stabilization 27637147 1 0 0 -Nfe2l2 NRF2 DNA-binding; Transcription factor Q60795 18024 2 C3|2 44.75 cM mouse S342-p 18258503 SGISLNTsPSRASPE protein degradation; molecular association, regulation BTRC(INDUCES) 21245377 3 1 0 -CDKN1B p27Kip1 Cell cycle regulation; Inhibitor; Oncoprotein; Protein kinase, regulatory subunit P46527 1027 12p13.1 human K165-ub 5018203 DDSSTQNkRANRTEE protein degradation; ubiquitination cell cycle regulation; cell growth, induced 10318797; 19056892; 31451788 3 0 0 degrade Cdkn1b for optimal ?-selection associated proliferation -H4c2 H4 DNA-binding P62806 326620 13|13 A3.1 mouse K20-m1 1458623 GGAKRHRkVLRDNIQ CENP-T_C cell cycle regulation; chromatin organization, altered; transcription, induced 19434510; 23428873; 23468428; 28746875 30 15 7 -MCU MCU Membrane protein, integral; Membrane protein, multi-pass; Mitochondrial Q8NE86 90550 10q22.1 human S92-p 27259017 VISVRLPsRRERCQF molecular association, regulation; protein conformation MCU(DISRUPTS) 26341627; 32499574 4 0 0 MCU-mediated mitochondrial Ca2+uptake, S92A mutant has a conformational change in L2-L4 loops which impairs Ca2+uptake.; inhibits dimerization; Regulates MCU activity -Ntrk2 TrkB EC 2.7.10.1; KINASE; Kinase, protein; Membrane protein, integral; Protein kinase, TK; Protein kinase, tyrosine (receptor) Q63604 25054 17p14 rat Y706-p 448812 DVYSTDYyRVGGHTM PK_Tyr_Ser-Thr molecular association, regulation; enzymatic activity, induced translation, altered; transcription, altered PLCG1(INDUCES); SHC1(INDUCES) 10533983; 16223723; 9582017 13 0 28 -EGLN1 EGLN1 EC 1.14.11.29; Oxidoreductase Q9GZT9 54583 1q42.2 human S61-p 56668114 HKLVCQGsEGALGHG enzymatic activity, inhibited signaling pathway regulation 35538889 1 2 0 regulates PHD2/HIFa/hepcidin/ferroportin signalling -Nr1h3 LXR-alpha DNA-binding; Motility/polarity/chemotaxis; Nuclear receptor Q9Z0Y9 22259 2 E1|2 50.52 cM mouse S291-p 479434 QIALLKTsAIEVMLL Hormone_recep molecular association, regulation; activity, inhibited transcription, inhibited; signaling pathway regulation SRC-1(DISRUPTS); N-CoR1(INDUCES); RXRA(DISRUPTS) 17296605 1 0 0 DNA Binding Activity of LXR/ RXR heterodimer was decreased. -TERF2 TRF2 DNA repair, damage; DNA-binding Q15554 7014 16q22.1 human R69-me 10338219 SRSSGRArRGRHEPG cell cycle regulation; cell growth, altered 19596784 1 0 0 -SMARCA4 SMARCA4 Cell cycle regulation; EC 3.6.1.-; EC 3.6.4.-; Helicase; Nuclear receptor co-regulator; Transcription, coactivator/corepressor; Tumor suppressor P51532 6597 19p13.2 human S1452-p 3191581 RPPAEKLsPNPPNLT ubiquitination carcinogenesis, induced; chromatin organization, altered; cell motility, induced; cell growth, induced 34237461 2 58 6 induces protein ubiquitination -Foxo1 FOXO1A DNA-binding; Nuclear receptor co-regulator; Oncoprotein; Transcription factor Q9R1E0 56458 3 C|3 23.19 cM mouse S429-p 478370 TYGQSSMsPLPQMPM FOXO_KIX_bdg molecular association, regulation transcription, inhibited DUSP6(INDUCES) 22848439 2 3 0 -CDKN2A p16-INK4A Cell cycle regulation; Nucleolus; Tumor suppressor P42771 1029 9p21.3 human S152-p 448832 IDAAEGPsDIPD___ protein stabilization; molecular association, regulation CDK4(INDUCES) 21270107 3 1 0 -PSME3 PSME3 Nuclear receptor co-regulator; Protease; Proteasome complex P61289 10197 17q21.31 human K195-ac 11318346 KLVSKIAkYPHVEDY PA28_beta molecular association, regulation; protein conformation; enzymatic activity, induced cell cycle regulation; cell growth, induced PSME3(INDUCES) 23612972 1 2 0 PSME3 heptamerization -RBM8A RBM8A RNA splicing; RNA-binding; Spliceosome; Translation Q9Y5S9 9939 1q21.1 human S168-p 456535 GGRRRSRsPDRRRR_ molecular association, regulation RNA splicing, altered UPF3B(DISRUPTS); NCBP1(DISRUPTS); THOC4(DISRUPTS); TAP(DISRUPTS); RPL22(DISRUPTS) 16100109 3 9 3 Phosphorylation is required for release downstream factors. Phosphorylation interferes with RBM8A's arginine methylation in vitro (by rat PRMT1) and in vivo. -AKT1S1 PRAS40 Apoptosis Q96B36 84335 19q13.33 human S183-p 482839 PTQQYAKsLPVSVPV PRAS molecular association, regulation mTOR(INDUCES); Raptor(DISRUPTS) 17517883; 21914810 5 66 25 -MCOLN1 mucolipin 1 Channel, cation; Membrane protein, integral; Membrane protein, multi-pass; Transporter, ion channel Q9GZU1 57192 19p13.2 human S559-p 1233700 KFRRGSGsACSLLCC activity, inhibited 17988215 1 3 0 -ITSN1 ITSN1 Adaptor/scaffold; Calcium-binding; GEF; GEF, Rac/Rho Q15811 6453 21q22.11 human T839-p 11125309 TPAPLAVtSSEPSTT INTAP molecular association, regulation; intracellular localization SYN1(INDUCES) 29078407 1 0 1 presynaptic nanoscale distribution of synapsin I -Fxyd1 PLM Cell surface; Channel, misc.; Membrane protein, integral O08589 58971 1q21 rat T89-p 455220 SSIRRLStRRR____ activity, induced; intracellular localization 19339511; 22535957 8 1 49 translocation to the cell surface -ZNF804B ZNF804B C2H2-type zinc finger protein A4D1E1 219578 7q21.13 human K163-ub 52490408 GRKVSCMkSALLLKG protein degradation 26676607 0 1 0 -Sh2b1 SH2-B-beta Adaptor/scaffold Q62985 89817 1q36 rat S165-p 21336501 VGRSVRGsVRGILQW intracellular localization cell motility, induced 23444381 2 0 0 disrupt localization at the plasma membrane.; macrophage migration -Adcy2 ADCY2 Adenylyl cyclase; EC 4.6.1.1; Lyase; Membrane protein, integral; Membrane protein, multi-pass; Nucleotide Metabolism - purine; Transporter; Transporter, aquaporin family P26769 81636 1p11 rat S490-p 25795203 DGAKMRAsVRMTRYL activity, induced 22906005 1 0 0 cAMP release -BANP BANP Tumor suppressor Q8N9N5 54971 16q24.2 human T337-p 41301700 VKSFSRRtPNSSSYC intracellular localization 26080397 1 0 0 cytoplasmic localization -IRS1 IRS1 Adaptor/scaffold; Motility/polarity/chemotaxis P35568 3667 2q36.3 human S307-p 450190 TRRSRTEsITATSPA molecular association, regulation; intracellular localization; phosphorylation INSR(DISRUPTS) 15143153; 16129690; 16914728; 34253290 56 12 1 disassociation of IRS2 from plasma membrane to cytosol; via cell fractionation experiments; limits PM-associated PI3K and PIP3 synthesis -H3C1 H3 DNA-binding P68431 8350 6p22.2 human S10-p 455676 TKQTARKsTGGKAPR Histone activity, induced; molecular association, regulation; acetylation; intracellular localization; methylation cell cycle regulation; carcinogenesis, induced; apoptosis, induced; transcription, induced; transcription, altered; cell growth, induced; chromatin organization, altered; apoptosis, inhibited; cytoskeletal reorganization; cell growth, altered H2AFV(INDUCES); 14-3-3 zeta(INDUCES); 14-3-3 epsilon(INDUCES); MYST1(INDUCES); H2AZ(INDUCES); BRD4(NOT_REPORTED); HP1 alpha(DISRUPTS) DNA(INDUCES) 10949293; 11784863; 12039950; 12234980; 12588998; 16222244; 16223729; 16354694; 16651411; 16687578; 17409387; 17643117; 17646159; 17891183; 17938195; 18234970; 18418070; 18418385; 18835819; 19766566; 19995936; 20003410; 21389100; 21820363; 21900495; 21900751; 22281053; 24876101; 25535969; 25553095; 25958199; 26607113; 27002159; 27162363; 27582276; 30115982; 30573684; 30626720; 33574676; 34570813; 34737366 241 15 1 -CDC25B CDC25B EC 3.1.3.48; Motility/polarity/chemotaxis; Nuclear receptor co-regulator; PHOSPHATASE; Protein phosphatase, dual-specificity P30305 994 20p13 human S323-p 448409 QRLFRSPsMPCSVIR M-inducer_phosp molecular association, regulation cell cycle regulation 14-3-3 beta(INDUCES); 14-3-3 epsilon(INDUCES) 11333986; 15629715 13 9 30 -Zap70 ZAP70 EC 2.7.10.2; KINASE; Kinase, protein; Protein kinase, TK; Protein kinase, tyrosine (non-receptor) P43404 22637 1 B|1 15.41 cM mouse Y318-p 447587 TSVYESPySDPEELK protein degradation; ubiquitination; protein conformation; phosphorylation signaling pathway regulation 21829558; 34452999; 35860252 58 7 263 regulates TCR signaling -Fancm FANCM EC 3.6.4.13; Helicase Q8BGE5 104806 12 C1|12 27.21 cM mouse S1025-p 28117600 ASHSAGNsQQNLESN molecular association, regulation MCM2(INDUCES) 31067464 2 1 0 -TBL1XR1 TBL1XR1 Nuclear receptor co-regulator; Transcription, coactivator/corepressor Q9BZK7 79718 3q26.32 human S123-p 2509601 AAASQQGsAKNGENT protein degradation transcription, induced 18374649 1 2 0 -SNCA SNCA Adaptor/scaffold P37840 6622 4q22.1 human K12-ub 466354 MKGLSKAkEGVVAAA Synuclein ubiquitination; phosphorylation 16847063 1 2 0 SNCA is phosphorylated, truncated, and then deposited to Lewy bodies.and then ubiquitinated which occurs at K12, K21. and K23 -ACLY ACLY Carbohydrate Metabolism - citrate (TCA) cycle; EC 2.3.3.8; Lyase; Transferase P53396 47 17q21.2 human K540-ac 31068004 FTGDHKQkFYWGHKE CoA_binding protein stabilization; molecular association, regulation; ubiquitination carcinogenesis, induced; cell growth, induced UBR4(INDUCES) 23932781; 31197036 2 1 7 inhibits ubiquitination, high glucose decreases interaction -ST13 HIP Adaptor/scaffold; Chaperone P50502 6767 22q13.2 human S346-p 21006300 AQNPANMsKYQSNPK STI1 receptor internalization, induced exocytosis, induced 21728385 1 1 0 required for agonist-induced internalization of CXCR4 -Adcy8 ADCY8 Adenylyl cyclase; EC 4.6.1.1; Lyase; Membrane protein, integral; Membrane protein, multi-pass; Nucleotide Metabolism - purine; Transporter; Transporter, aquaporin family P97490 11514 15 D1|15 29.03 cM mouse S113-p 26392110 VFPERSGsGSASGSG activity, inhibited 22976297 1 0 0 -Prkce PKCE EC 2.7.11.13; KINASE; Kinase, protein; Protein kinase, AGC; Protein kinase, Ser/Thr (non-receptor) P16054 18754 17|17 E4 mouse S346-p 2807904 SEDDRSKsAPTSPCD cell cycle regulation 18604201 3 11 0 -CRTC1 TORC1 iso2 Transcription factor Q6UUV9-2 23373 19p13.11 human S188-p 481987 PESFSSGsQDVHQKR TORC_M protein degradation transcription, inhibited 29408765 1 3 2 -MDC1 MDC1 Cell cycle regulation Q14676 9656 6p21.33 human T455-p 453677 TTERDSDtDVEEEEL molecular association, regulation cell cycle regulation NBS1(INDUCES) 18678890 1 37 95 MDC1-NBS1 interaction regulates intra-S-phase checkpoint activation -Flot2 FLOT2 Cell adhesion Q9Z2S9 83764 10q25 rat Y24-p 1270903 GGCCGSDyKQYVFGG Band_7 cell motility, altered; cytoskeletal reorganization 17213334 1 0 0 -NOX5 NOX5 iso4 EC 1.6.3.-; Membrane protein, integral; Membrane protein, multi-pass; Oxidoreductase Q96PH1-4 79400 15q23 human T494-p 472625 KRLSRSVtMRKSQRS FAD_binding_8 activity, induced; enzymatic activity, induced 17164239; 24505490; 24992705 5 0 0 -NPM1 NPM1 Nucleolus; Oncoprotein; RNA-binding; Translation P06748 4869 5q35.1 human K230-sm 1189202 KGQESFKkQEKTPKT molecular association, regulation apoptosis, inhibited; transcription, induced Rb(INDUCES) 17535915 3 0 0 promotes cell survival.; wild-type B23 slightly diminished DNA degradation -CEBPB C/EBP-beta DNA-binding; Motility/polarity/chemotaxis; Transcription factor P17676 1051 20q13.13 human K174-sm 6140810 PPPPAELkAEPGFEP molecular association, regulation transcription, inhibited HDAC4(INDUCES) 12810706; 18820298 3 2 0 -SPAST spastin Cytoskeletal; EC 3.6.4.3; Membrane protein, integral Q9UBP0 6683 2p22.3 human T306-p 3214842 NKPSTPTtATRKKKD intracellular localization cytoskeletal reorganization 32979422 2 3 7 involved in microtubule severing -TERT TERT iso3 DNA-binding; EC 2.7.7.49; Nucleolus; Transferase O14746-3 7015 5p15.33 human K78-ub 14561002 FRQVSCLkELVARVL protein degradation chromatin organization, altered; apoptosis, induced 20453884 1 0 0 -NR1H4 NR1H4 iso2 DNA-binding; Nuclear receptor Q96RI1-2 9971 12q23.1 human K122-sm 31089518 GASAGRIkGDELCVV molecular association, regulation transcription, inhibited DNA(DISRUPTS) 23546875 1 0 0 -H3c1 H3 DNA-binding P68433 360198 13|13 A3.1 mouse K36-ac 466364 APATGGVkKPHRYRP Histone molecular association, regulation; intracellular localization transcription, induced DNA(INDUCES) 17189264; 20561915 8 7 6 -Grm5 mGluR5 GPCR, family 3; Membrane protein, integral; Membrane protein, multi-pass; Receptor, GPCR P31424 24418 1q32 rat S1158-p 25581600 LVALTPPsPFRDSVD GluR_Homer-bdg neural plasticity 24769228 4 0 0 -Tnni3 TNNI3 Actin-binding; Motility/polarity/chemotaxis; Motor P23693 29248 1q12 rat S43-p 450690 AKKKSKIsASRKLQL cell motility, altered 16936010 24 2 0 heart contractility and relaxation -Hand1 HAND1 Cell development/differentiation; DNA-binding; Nucleolus; Transcription factor Q64279 15110 11 B1.3|11 35.27 cM mouse S109-p 12518702 KERRRTEsINSAFAE HLH intracellular localization; protein conformation cell differentiation, altered 17891141 1 0 0 release from nucleolus, dimerization -MIIP MIIP Motility/polarity/chemotaxis Q5JXC2 60672 1p36.22 human S303-p 4170074 YHIHRRKsFDASDTL MIIP molecular association, regulation cell motility, induced; transcription, induced NFkB-p65(INDUCES) 29038521 1 22 2 tumor metastasis -ITGB4 ITGB4 iso2 Cell adhesion; Membrane protein, integral; Motility/polarity/chemotaxis; Receptor, misc. P16144-2 3691 17q25.1 human T1727-p 480544 GSLTRHVtQEFVSRT molecular association, regulation; protein conformation Plectin-1(DISRUPTS); ITGB4 iso2(INDUCES) 22357621 1 4 15 regulates HD assembly -RB1 Rb Nuclear receptor co-regulator; Oncoprotein; Transcription, coactivator/corepressor; Tumor suppressor P06400 5925 13q14.2 human T826-p 447984 LPTPTKMtPRSRILV Rb_C molecular association, regulation cell cycle regulation; cell growth, induced; transcription, induced; cell growth, altered Elf-1(DISRUPTS); E2F1(DISRUPTS); Rb(INDUCES); TFDP1(DISRUPTS) DNA(DISRUPTS) 16360038; 34158578; 36047562; 8626527; 9315635 20 37 56 -RAPGEF1 RAPGEF1 GEF; GEF, Ras; Motility/polarity/chemotaxis Q13905 2889 9q34.13 human Y504-p 448393 APIPSVPyAPFAAIL activity, induced; intracellular localization; enzymatic activity, induced; phosphorylation cell cycle regulation; apoptosis, altered; cell growth, induced; cell differentiation, induced; signaling pathway regulation; transcription, altered 10318861; 12734187; 15320955; 18957052; 20581864; 21876762; 24396067; 28790195; 30567575; 32296045 12 0 0 regulates the ADP-P2Y12-PI3K-Rap1 pathway; neurite growth -GLS glutaminase Amino Acid Metabolism - alanine, aspartate and glutamate; Amino Acid Metabolism - arginine and proline; EC 3.5.1.2; Energy Metabolism - nitrogen; Hydrolase; Mitochondrial; Other Amino Acids Metabolism - D-Glutamine and D-glutamate O94925 2744 2q32.2 human K311-ac 7248642 YVHRYVGkEPSGLRF Glutaminase ubiquitination; enzymatic activity, inhibited; protein conformation carcinogenesis, inhibited; cell growth, inhibited; cell motility, inhibited glutaminase(INDUCES); TRIM21(INDUCES) 23935106; 35864951 2 4 1 interaction between TRIM21 and GAC led to K63-linked ubiquitination and inhibited GAC enzymatic activity; TEM micrographs, K311 acetylation induces inhibition of superoligomer assembly -SPRTN SPRTN DNA repair, damage Q9H040 83932 1q42.2 human K230-ac 1875273400 KGKAKLGkEPVLAAE intracellular localization 32649882 1 0 0 recruitment to chromatin, DNA-protein crosslinks (DPCs) repair -IRAK1 IRAK1 EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, Ser/Thr (non-receptor); Protein kinase, TKL P51617 3654 Xq28 human S131-p 4273531 PAEAEAWsPRKLPSS molecular association, regulation; enzymatic activity, induced transcription, induced PIN1(INDUCES) 21743479; 27790836 2 9 0 -Klf5 KLF5 C2H2-type zinc finger protein; DNA-binding; Transcription factor Q9Z0Z7 12224 14|14 E2.2 mouse K202-sm 4664700 EVNNIFIkQELPIPD intracellular localization carcinogenesis, induced; cell growth, induced 18782761 2 1 0 -Mef2c MEF2C DNA-binding; Transcription factor Q8CFN5 17260 13 C3|13 43.68 cM mouse T20-p 455602 DERNRQVtFTKRKFG SRF-TF apoptosis, inhibited; transcription, altered 15735306 1 0 0 -Ikzf1 Ikaros C2H2-type zinc finger protein; DNA-binding; Transcription factor Q03267 22778 11 A1|11 7.02 cM mouse S214-p 28735107 RSYKQRSsLEEHKER zf-C2H2 molecular association, regulation; intracellular localization transcription, induced DNA(INDUCES) 23977012 1 1 0 nuclear localization, ITGA4, MDM1, EIF4E3, KIF23, TNFAIP8L2 DNA binding/transcription inhibited by BTK siRNA -Prkab1 AMPKB1 Autophagy; KINASE; Protein kinase, regulatory subunit P80386 83803 12q16 rat S25-p 448112 KTPRRDSsGGTKDGD intracellular localization 11171104 3 1 4 -Ido1 INDO Amino Acid Metabolism - tryptophan; Cell cycle regulation; EC 1.13.11.52; Oxidoreductase P28776 15930 8|8 A2 mouse Y253-p 21393601 KLPEGLLyEGVWDTP IDO molecular association, regulation transcription, induced; signaling pathway regulation SHP-2(INDUCES); SHP-1(INDUCES) 21804557 1 0 0 Phosphorylation of INDO at Y115 and Y253 induced enzyme activity of SHP-1/SHP-2. -SLC4A1 SLC4A1 Membrane protein, integral; Membrane protein, multi-pass; Transporter; Transporter, SLC family P02730 6521 17q21.31 human Y359-p 455384 AKPDSSFyKGLDLNG activity, induced; molecular association, regulation; intracellular localization; phosphorylation SHP-2(INDUCES) 12070037; 15649129; 18827007; 32411010; 32517126 8 5 50 induces capacitation, AR and viability -MEF2D MEF2D DNA-binding; Transcription factor Q14814 4209 1q22 human S251-p 3196577 NKVIPAKsPPPPTHS intracellular localization; activity, inhibited transcription, inhibited 34109727 2 43 5 phosphorylation of this site inhibits MEF2D import into the nucleus -CERS2 LASS2 DNA-binding; Membrane protein, integral; Membrane protein, multi-pass; Transferase Q96G23 29956 1q21.3 human T346-p 469769 ERSDREEtESSEGEE enzymatic activity, induced 26887952 1 42 217 -Gata1 GATA1 DNA-binding; Transcription factor P17679 14460 X A1.1|X 3.59 cM mouse K137-sm 3819000 NTFLDTLkTERLSPD transcription, inhibited 15173587 4 0 0 inhibition of GATA-1 transcription is specific -AP4E1 AP4E1 Adaptor/scaffold Q9UPM8 23431 15q21.2 human S871-p 22598800 VEKFSYCsLSTPSLF receptor recycling, inhibited 21810154 1 0 0 -Anxa1 ANXA1 Calcium-binding; Lipid-binding P10107 16952 19 B|19 13.83 cM mouse S27-p 447972 EYVQAVKsYKGGPGS intracellular localization 16720734 8 0 0 -Foxp1 FOXP1 C2H2-type zinc finger protein; Cell cycle regulation; DNA-binding; Transcription factor P58462 108655 6|6 D3 mouse K664-sm 610814010 AVHPIHVkEEPLDPE molecular association, regulation cell differentiation, altered; cell motility, induced; cell growth, induced; cytoskeletal reorganization HDAC1(DISRUPTS); HDAC2(DISRUPTS); MTA2(DISRUPTS); MTA1(DISRUPTS) 29138280 2 1 0 -SPRY2 SPRY2 Adaptor/scaffold; Inhibitor; Motility/polarity/chemotaxis O43597 10253 13q31.1 human Y283-p 3978700 LKLCQGCyDRVNRPG Sprouty activity, inhibited; phosphorylation transcription, altered 15637081 1 0 0 -Ulk1 ULK1 Autophagy; EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, Other; Protein kinase, Ser/Thr (non-receptor) O70405 22241 5|5 F mouse S415-p 4958506 CSSSPSPsGRPGPFS molecular association, regulation; phosphorylation; enzymatic activity, induced carcinogenesis, induced; autophagy, induced LC3B(INDUCES); GABARAPL1(INDUCES) 33654220 1 1 2 induces phosphorylation of itself at the other site and of BECN1 and ATG13 -CEP131 CEP131 Calcium-binding Q9UPN4 22994 17q25.3 human S78-p 1211822 NNLRRSNsTTQVSQP molecular association, regulation cell cycle regulation; cytoskeletal reorganization 14-3-3 zeta(INDUCES); 14-3-3 epsilon(INDUCES) 26616734; 30804208 2 28 61 maintain integrity of centriolar satellites in interphase; 14-3-3-dependent centriolar satellite remodelling upon cell stress. -LRRK2 LRRK2 EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, Ser/Thr (non-receptor); Protein kinase, TKL Q5S007 120892 12q12 human T1343-p 10426319 KLMIVGNtGSGKTTL Roc molecular association, regulation; protein conformation TUBB(DISRUPTS) 21806997; 24275654 6 5 0 -Syn1 SYN1 Vesicle P09951 24949 Xq11 rat S9-p 448378 NYLRRRLsDSNFMAN Synapsin_N activity, induced; intracellular localization neural plasticity 14557263; 19896987; 23461423 25 5 2 -CREBBP CBP ACETYLTRANSFERASE; Acetyltransferase; DNA-binding; EC 2.3.1.48; Motility/polarity/chemotaxis; Nuclear receptor co-regulator; Transcription, coactivator/corepressor Q92793 1387 16p13.3 human T1871-p 474502 LMRRRMAtMNTRNVP molecular association, regulation; ubiquitination carcinogenesis, induced; cell growth, induced; signaling pathway regulation MDM2(INDUCES) 22349818; 23434580 3 0 0 -MDC1 MDC1 Cell cycle regulation Q14676 9656 6p21.33 human T4-p 3965656 ____MEDtQAIDWDV molecular association, regulation; intracellular localization cell cycle regulation; DNA repair, induced MDC1(INDUCES) 22234877; 28193847 2 3 1 maintenance of chrosome stabiliy -TTK TTK Cancer Testis Antigen (CTA); EC 2.7.12.1; KINASE; Kinase, protein; Protein kinase, Other; Protein kinase, dual-specificity (non-receptor) P33981 7272 6q14.1 human T371-p 1737600 LLAKLEEtKEYQEPE intracellular localization; enzymatic activity, induced cell cycle regulation 25265012; 26119734 2 2 1 regulates spindle assembly checkpoint and recruitment of SAC proteins; autophosphorylation of this site is required for release TTK from kinetochore; causes decreased kinetochore localization of BubR1 and Mad2. -MAP4 MAP4 Cytoskeletal; Motility/polarity/chemotaxis P27816 4134 3p21.31 human K838-ac 15292997 PKKPTAIkTEGKPAE cytoskeletal reorganization 28002468 1 2 4 -Cebpa C/EBP-alpha DNA-binding; Transcription factor P05554 24252 1q21 rat K298-ac 56394104 RNNIAVRkSRDKAKQ bZIP_2 molecular association, regulation autophagy, induced beclin 1(INDUCES) 34217716 2 0 0 -PTPN1 PTP1B EC 3.1.3.48; Motility/polarity/chemotaxis; PHOSPHATASE; Phosphatase; Protein phosphatase, tyrosine (non-receptor) P18031 5770 20q13.13 human Y66-p 447812 LHQEDNDyINASLIK Y_phosphatase molecular association, regulation; enzymatic activity, induced INSR(INDUCES) 8999839; 9355745 3 2 44 -Sod2 SOD2 EC 1.15.1.1; Mitochondrial; Oxidoreductase P09671 20656 17 A1|17 8.75 cM mouse K134-ac 27585069 SFEKFKEkLTAVSVG Sod_Fe_C protein conformation; enzymatic activity, altered 28433661 0 3 0 -Gsdmd GSDMD Lipid-binding Q9D8T2 69146 15|15 D3 mouse S46-p 1883583906 CLLNRKFsSSRFWKP Gasdermin molecular association, regulation; intracellular localization carcinogenesis, induced GSDMD(DISRUPTS) 37495617 1 0 0 -STAT6 STAT6 DNA-binding; Transcription factor P42226 6778 12q13.3 human Y641-p 447757 MGKDGRGyVPATIKM molecular association, regulation; intracellular localization carcinogenesis, induced; cell differentiation, induced; transcription, induced; signaling pathway regulation STAT6(INDUCES) DNA(INDUCES) 22000020; 32015091; 34521750 27 6 95 induce HSD3B1 transcription -WWC1 KIBRA Adaptor/scaffold Q8IX03 23286 5q34 human S548-p 30312500 SSPSPPCsPLMADPL cell growth, induced 24269383 1 0 0 -Tnni3 TNNI3 Actin-binding; Motility/polarity/chemotaxis; Motor P23693 29248 1q12 rat S23-p 448423 PAPVRRRsSANYRAY Troponin-I_N protein conformation; activity, inhibited cell motility, altered; cytoskeletal reorganization 16236710; 16936010; 18550549; 28587770 68 11 11 heart contractility and relaxation; regulates cardiac contractile function -FRS2 FRS2 Adaptor/scaffold Q8WU20 10818 12q15 human Y349-p 449784 RRTALLNyENLPSLP molecular association, regulation cell differentiation, induced SOS1(INDUCES); GRB2(INDUCES) 11278583 3 11 89 -PAK6 PAK6 EC 2.7.11.1; KINASE; Kinase, protein; Nuclear receptor co-regulator; Protein kinase, STE; Protein kinase, Ser/Thr (non-receptor) Q9NQU5 56924 15q15.1 human Y566-p 454426 KSLVGTPyWMAPEVI Pkinase enzymatic activity, induced 15550393 1 0 1 -CACNA1C CACNA1C Channel, calcium; Membrane protein, integral; Membrane protein, multi-pass Q13936 775 12p13.33 human Y2217-p 1043301 ELQDSRVyVSSL___ activity, induced; molecular association, regulation Src(INDUCES) 17942635 2 0 0 -IRF3 IRF3 DNA-binding; Transcription factor Q14653 3661 19q13.33 human S82-p 1878269104 TWKRNFRsALNRKEG molecular association, regulation; intracellular localization transcription, inhibited DNA(DISRUPTS) 35948267 1 1 0 -SCML2 SCML2 Transcription factor Q9UQR0 10389 Xp22.13 human S511-p 449227 VPYVVPLsPKLPKTK cell cycle regulation 24358021 2 34 21 -PKMYT1 Myt1 EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, Other; Protein kinase, Ser/Thr (non-receptor); Protein kinase, dual-specificity (non-receptor) Q99640 9088 16p13.3 human S416-p 11331004 PPATPPGsPPCSLLL molecular association, regulation PIN1(INDUCES) 10504341 1 0 0 -Rrad RRAD G protein; G protein, monomeric; G protein, monomeric, RGK O88667 56437 8|8 D3 mouse S26-p 4700219 ERDRRRGsTPWGPAP activity, induced; molecular association, regulation CACNA1C(DISRUPTS) 31969708 2 6 1 induces Cav1.2 currents -Ezr Ezrin Cytoskeletal; Motility/polarity/chemotaxis P26040 22350 17|17 A1 mouse Y478-p 454875 PPPPPPVyEPVNYHV carcinogenesis, induced; cell motility, induced; cell growth, induced 22397367 10 4 137 -Pld1 PLD1 iso2 EC 3.1.4.4; Lipid Metabolism - ether lipid; Lipid Metabolism - glycerophospholipid; Motility/polarity/chemotaxis; Phospholipase P70496-2 25096 2q24 rat S561-p 448574 SRKFSKFsLYRQLHR enzymatic activity, induced 10441128; 10788479 3 4 0 -GLI1 GLI1 C2H2-type zinc finger protein; Oncoprotein; Transcription factor P08151 2735 12q13.3 human K415-sm 1873076604 SISTVEPkREREGGP protein stabilization; ubiquitination; intracellular localization cell growth, induced; transcription, induced; signaling pathway regulation 28630282 1 0 0 inhibits ubiquitination, enhances Shh signaling -CLDN3 Claudin-3 Cytoskeletal; Membrane protein, integral; Membrane protein, multi-pass O15551 1365 7q11.23 human T192-p 455751 PPREKKYtATKVVYS intracellular localization; activity, inhibited cell adhesion, altered 15905176 1 0 0 cell adhesion = tight junctions -PARP1 PARP1 DNA repair, damage; EC 2.4.2.30; Nuclear envelope; Nuclear receptor co-regulator; Nucleolus; Transferase P09874 142 1q42.12 human K209-ub 21180922 VKSEGKRkGDEVDGV cell motility, induced; cell growth, induced; apoptosis, inhibited; DNA repair, inhibited; signaling pathway regulation 36088509 1 1 0 HECTD3 activates the EGFR-mediated signalling pathway through PARP1. -HIPK2 HIPK2 EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, CMGC; Protein kinase, Ser/Thr (non-receptor) Q9H2X6 28996 7q34 human T1114-p 28847906 APAALGStGTVAHLV protein stabilization; molecular association, regulation; phosphorylation; enzymatic activity, induced PPM1D(DISRUPTS) 23871434 1 0 0 increase protein stabilization and reduce phosphorylation of WIP1 -Ppargc1a PGC-1 alpha Nuclear receptor co-regulator; Transcription, coactivator/corepressor O70343 19017 5|5 C1 mouse S568-p 20612406 PQRMRSRsRSFSRHR protein stabilization; molecular association, regulation; activity, inhibited transcription, inhibited; signaling pathway regulation HNF4 alpha(DISRUPTS) 21646374; 23201126 2 0 0 Gluconeogenic pathway; Regulation of gluconeogenesis -Ascl1 ASCL1 DNA-binding; Transcription factor Q02067 17172 10|10 C1 mouse S150-p 453455 GAANKKMsKVETLRS HLH protein stabilization; molecular association, regulation transcription, inhibited E2A iso2(INDUCES) 15318167 1 0 0 -Rptor Raptor Adaptor/scaffold Q8K4Q0 74370 11|11 E2 mouse S792-p 2314600 DKMRRVSsYSALNSL molecular association, regulation; phosphorylation cell cycle regulation; transcription, altered; signaling pathway regulation; translation, inhibited 14-3-3 zeta(INDUCES); 14-3-3 gamma(INDUCES) 18439900; 26357899; 32912901 36 4 0 inhibits mTORC1 signaling; inhibits S6 and ULK1 phosphorylation through inhibiting mTORC1 signaling -SNAI1 Snail1 C2H2-type zinc finger protein; Transcription factor O95863 6615 20q13.13 human S119-p 6097706 SFSSTSVsSLEAEAY intracellular localization cell motility, altered; transcription, altered 15448698; 19004823 2 0 0 Localization mediated by S107, S111, S115 and S119. -GAB2 GAB2 Adaptor/scaffold Q9UQC2 9846 11q14.1 human S210-p 4825112 AENARSAsFSQGTRA molecular association, regulation; intracellular localization; activity, inhibited; phosphorylation cell growth, altered 14-3-3 beta(INDUCES); SHC1(DISRUPTS); GRB2(DISRUPTS); EGFR(DISRUPTS) 19172738 3 19 8 -SHC1 SHC1 iso2 Adaptor/scaffold; Apoptosis; Mitochondrial; Motility/polarity/chemotaxis P29353-2 6464 1q21.3 human Y240-p 448510 EPPDHQYyNDFPGKE activity, induced; molecular association, regulation; activity, inhibited; phosphorylation cell growth, induced; cell motility, altered; transcription, induced; cytoskeletal reorganization GRB2(INDUCES); SHIP(INDUCES); GRB2(DISRUPTS); ZAP70(INDUCES); VAV1(INDUCES) 10598576; 10891441; 17537990; 9121430; 9813159 29 22 943 Y317F activates MAPK; f-actin cytoskeleton, chemotaxis. -DDHD1 DDHD1 EC 3.1.1.-; Phospholipase Q8NEL9 80821 14q22.1 human S8-p 22351354 MNYPGRGsPRSPEHN phosphorylation 34089703 1 10 0 regulates phosphorylation at other sites -Opn4 melanopsin GPCR, family 1; Membrane protein, integral; Membrane protein, multi-pass; Receptor, GPCR Q9QXZ9 30044 14|14 B mouse S394-p 23257073 RSTLSSQsSDLSWIS molecular association, regulation; protein conformation ARRB1(INDUCES) 32236094 1 1 1 -PRL prolactin Cytokine; Motility/polarity/chemotaxis; Secreted; Secreted, signal peptide P01239 280901 cow S120-p 451505 LILGLLRsWNDPLYH Hormone_1 protein conformation; activity, inhibited 12850287 2 0 0 -CSK CSK EC 2.7.10.2; KINASE; Kinase, protein; Protein kinase, TK; Protein kinase, tyrosine (non-receptor) P41240 1445 15q24.1 human S364-p 448477 ALREKKFsTKSDVWS PK_Tyr_Ser-Thr phosphorylation; enzymatic activity, induced PKACA(INDUCES) 11181701; 12600271 5 0 0 In vitro the presence of SH3 domain of CSK greatly increases phosphotransferase activity of CSK. PKA mediated phosphorylation of S364 is independent of SH3 domain. -PDGFRB PDGFRB EC 2.7.10.1; KINASE; Kinase, protein; Membrane protein, integral; Oncoprotein; Protein kinase, TK; Protein kinase, tyrosine (receptor) P09619 5159 5q32 human Y686-p 7437801 IITEYCRyGDLVDYL PK_Tyr_Ser-Thr enzymatic activity, induced cell motility, altered 19275932 1 3 1 in vitro -CHKA CHKA EC 2.7.1.32; EC 2.7.1.82; Kinase, other; Lipid Metabolism - glycerophospholipid P35790 1119 11q13.2 human S279-p 1876872804 KKLHKLLsYNLPLEL Choline_kinase carcinogenesis, induced; cell growth, induced; apoptosis, inhibited 35463311 1 0 0 -PRKAA2 AMPKA2 Autophagy; EC 2.7.11.1; EC 2.7.11.27; EC 2.7.11.31; KINASE; Kinase, protein; Protein kinase, CAMK; Protein kinase, Ser/Thr (non-receptor) P54646 5563 1p32.2 human K379-ub 27177165 PLIADSPkARCPLDA enzymatic activity, inhibited 31996460 1 1 0 -Hdac5 HDAC5 DEACETYLASE; Deacetylase; EC 3.5.1.98; Hydrolase Q9Z2V6 15184 11|11 D mouse S488-p 447996 RPLSRTQsSPLPQSP molecular association, regulation 14-3-3 epsilon(INDUCES); MEF2C(DISRUPTS) 11114197 24 7 4 -SHC3 SHC3 iso2 Adaptor/scaffold; Motility/polarity/chemotaxis Q92529-2 53358 9q22.1 human Y218-p 451254 GDGSDHPyYNSIPSK molecular association, regulation CRK(INDUCES); RAPGEF1(INDUCES) 11791173 3 1 3 -SYK Syk EC 2.7.10.2; KINASE; Kinase, protein; Protein kinase, TK; Protein kinase, tyrosine (non-receptor) P43405 6850 9q22.2 human S297-p 1983707 ISRIKSYsFPKPGHR molecular association, regulation; ubiquitination; intracellular localization; phosphorylation signaling pathway regulation 14-3-3 gamma(INDUCES); ubiquitin(DISRUPTS); Ig-beta(DISRUPTS) 21469132 4 11 23 inhibits ubiquitination, inhibits phosphorylation of substrates and hence BCR signaling -Myl12b MRLC2 Contractile Q3THE2 67938 17|17 E1.3 mouse S20-p 448595 KRPQRATsNVFAMFD activity, induced; molecular association, regulation cell motility, induced; apoptosis, inhibited; cytoskeletal reorganization 11485996; 19062278; 34113824 62 64 295 -IRS1 IRS1 Adaptor/scaffold; Motility/polarity/chemotaxis P35568 3667 2q36.3 human S270-p 447566 EFRPRSKsQSSSNCS molecular association, regulation; intracellular localization 14-3-3 beta(INDUCES) 34253290; 9312143 6 15 31 -Gata4 GATA4 Motility/polarity/chemotaxis; Transcription factor Q08369 14463 14 D1|14 33.24 cM mouse K311-ac 18380901 PRPLAMRkEGIQTRK cell growth, induced; transcription, induced 20833366 2 0 0 -Kcnj5 GIRK4 Channel, potassium; Membrane protein, integral; Membrane protein, multi-pass P48548 29713 8q21 rat S191-p 450684 GCMFVKIsQPKKRAE IRK activity, inhibited 14732702 1 0 0 inhibition of channel open-state probability -XRCC5 Ku80 DNA-binding; EC 3.6.1.-; EC 3.6.4.-; Helicase; Nuclear receptor co-regulator; Nucleolus; RNA-binding P13010 7520 2q35 human K532-ub 10836853 KSQIPLSkIKTLFPL Ku_C molecular association, regulation DNA repair, induced DNA(DISRUPTS) 27895153 1 8 57 -FADD FADD Adaptor/scaffold; Apoptosis Q13158 8772 11q13.3 human K149-sm 62489902 RESLRIWkNTEKENA Death molecular association, regulation; intracellular localization CASP10(INDUCES); DRP1(INDUCES) 27799292 1 0 0 -SNAI1 Snail1 C2H2-type zinc finger protein; Transcription factor O95863 6615 20q13.13 human S249-p 1867725600 ARTFSRMsLLHKHQE protein degradation; molecular association, regulation; ubiquitination carcinogenesis, inhibited; signaling pathway regulation PAR3(INDUCES); BTRC(INDUCES) 30804505 1 0 0 -H3c1 H3 DNA-binding P68433 360198 13|13 A3.1 mouse T58-p 481137 IRRYQKStELLIRKL Histone molecular association, regulation chromatin organization, altered; transcription, inhibited DNA(DISRUPTS) 26199864 1 10 0 -Inpp5d SHIP EC 3.1.3.86; Motility/polarity/chemotaxis; Phosphatase, lipid Q9ES52 16331 1 D|1 44.44 cM mouse Y1021-p 448865 EMFENPLyGSVSSFP molecular association, regulation SHIP(INDUCES); SHC1(INDUCES); DOK1(INDUCES) 11031258; 22182704; 9099679 10 15 202 -STIM1 STIM1 Calcium-binding; Endoplasmic reticulum; Membrane protein, integral Q13586 6786 11p15.4 human S621-gl 1870757303 SRSHSPSsPDPDTPS molecular association, regulation; activity, inhibited; phosphorylation EB1(DISRUPTS); ORAI1(INDUCES) 33023909 1 0 0 phosphorylation of STIM1 at S621may increase SOCE activity -Cald1 Caldesmon Actin-binding Q62736 25687 4q22 rat S497-p 448465 KSPDGNKsPAPKPSD Caldesmon intracellular localization cytoskeletal reorganization 16289153 7 21 0 -CDC73 CDC73 Cell cycle regulation; Tumor suppressor Q6P1J9 79577 1q31.2 human Y293-p 20831311 IPAAYNRyDQERFKG CDC73_N molecular association, regulation; protein conformation transcription, inhibited; signaling pathway regulation CTNNB1(DISRUPTS) 21726809 1 0 0 inhibits Wnt signaling pathway -PKN1 PKN1 EC 2.7.11.13; KINASE; Kinase, protein; Protein kinase, AGC; Protein kinase, Ser/Thr (non-receptor) Q16512 5585 19p13.12 human S537-p 483282 GTFSPGAsPGSEART enzymatic activity, induced carcinogenesis, induced; cell motility, induced; cell growth, induced 31981797 1 33 2 induces anchorage-independent cell growth -Ndel1 NDEL1 Microtubule-binding; Protease Q9ERR1 83431 11|11 B3 mouse S242-p 3685801 IPNGFGTsPLTPSAR NUDE_C activity, induced; intracellular localization cell motility, altered 18331715 3 4 1 Cdc42 activation -SLC12A3 NCCT Membrane protein, integral; Membrane protein, multi-pass; Transporter; Transporter, SLC family P55017 6559 16q13 human T60-p 469617 MRTFGYNtIDVVPTY AA_permease_N activity, induced; molecular association, regulation; protein conformation ADD3(DISRUPTS) 18270262; 21164023; 36792826 25 3 0 -FANCD2 FANCD2 DNA repair, damage Q9BXW9 2177 3p25.3 human S319-p 34734267 LPSRLQAsQVKLKSK FancD2 activity, induced; molecular association, regulation; ubiquitination; intracellular localization signaling pathway regulation DNA(INDUCES) 37392383 1 3 12 regulates the FA pathway -CD19 CD19 Cell surface; Membrane protein, integral P15391 930 16p11.2 human Y378-p 463123 LGGTAPSyGNPSSDV activity, induced; molecular association, regulation SOS1(INDUCES); GRB2(INDUCES) 10706702 1 1 4 -Lcp1 L-plastin Actin-binding; Motility/polarity/chemotaxis Q61233 18826 14 D3|14 39.63 cM mouse S5-p 450852 ___MARGsVSDEEMM endocytosis, induced; cytoskeletal reorganization 30248139; 33858961 15 49 4 induces phagocytosis; sealing ring formation (nascent sealing zone) in osteoclasts, bone resorption -Hspb1 HSP27 Chaperone; Heat shock protein; Motility/polarity/chemotaxis; SUMO LIGASE; SUMO ligase P42930 24471 12q12 rat S15-p 448401 FSLLRSPsWEPFRDW intracellular localization 36260112 52 78 30 -MOK MOK EC 2.7.11.22; KINASE; Kinase, protein; Protein kinase, CMGC; Protein kinase, Ser/Thr (non-receptor) Q9UQ07 5891 14q32.31 human Y161-p 450006 SKQPYTEyISTRWYR Pkinase activity, induced 10421840 1 1 0 While the authors did not prove that these sites were phosphorylated, mutation of both T159 and Y161, located in the activation loop, abolished the enzymatic activity of the kinase. -PHLPP1 PHLPP EC 3.1.3.16; PHOSPHATASE; Protein phosphatase, Ser/Thr (non-receptor); Tumor suppressor O60346 23239 18q21.33 human T1363-p 22769303 HVQSVLLtPQDEFFI PP2C protein degradation 19797085 1 1 0 PHLPP phosphorylation induces degradation and Akt1 activation negatively regulates degradation. -Bcl2l11 BIM Apoptosis O54918 12125 2|2 F1 mouse Y161-p 810853200 GDEFNETyTRRVFAN Bclx_interact protein stabilization apoptosis, inhibited 29391601 1 0 0 -Npm1 NPM1 Nucleolus; Oncoprotein; RNA-binding; Translation Q61937 18148 11|11 A4 mouse S48-p 14577038 QLSLRTVsLGAGAKD Nucleoplasmin protein conformation 24616519 2 3 0 -NDC80 HEC1 Cell cycle regulation O14777 10403 18p11.32 human S55-p 459763 PTSERKVsLFGKRTS Ndc80_HEC cell cycle regulation; chromatin organization, altered; cytoskeletal reorganization 17129782; 33988677; 35638575; 35878017; 36897279 14 13 0 -STK3 MST2 Autophagy; EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, STE; Protein kinase, Ser/Thr (non-receptor) Q13188 6788 8q22.2 human S15-p 4272103 KSKLKKLsEDSLTKQ molecular association, regulation; ubiquitination; intracellular localization; enzymatic activity, inhibited; phosphorylation cell cycle regulation; carcinogenesis, induced NEK2(DISRUPTS) 21723128; 35780183; 37739411 3 16 0 TRIM69 regulates centrosome dynamics and mitotic progression and centrosome amplification, regulates centrosome clustering, promotes triple-negative breast cancer; TRIM69A regulates MST2 ubiquitination and intracellular localization -RRM1 RRM1 DNA replication; EC 1.17.4.1; Nucleotide Metabolism - purine; Nucleotide Metabolism - pyrimidine; Other Amino Acids Metabolism - glutathione; Oxidoreductase P23921 6240 11p15.4 human S631-p 41454201 IYTRRVLsGEFQIVN Ribonuc_red_lgC molecular association, regulation; enzymatic activity, induced carcinogenesis, induced; cell growth, induced; apoptosis, inhibited RRM2(INDUCES) 34126361 1 2 0 regulates RNR enzymatic activity for DNA replication -Rps6kb1 p70S6K EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, AGC; Protein kinase, Ser/Thr (non-receptor); Translation Q8BSK8 72508 11|11 C mouse K516-ac 14790001 QAFPMISkRPEHLRM cell growth, induced 27345368 4 1 0 -Crtc3 TORC3 Transcription, coactivator/corepressor Q91X84 70461 7|7 D3 mouse S162-p 7101661 SALNRTNsDSALHTS TORC_M molecular association, regulation transcription, inhibited 14-3-3 beta(INDUCES) 23033494 1 8 2 inhibits nuclear localization -Runx2 AML3 iso5 DNA-binding; Transcription factor Q08775-5 12393 17 B3|17 21.33 cM mouse T326-p 14694701 SPSIHSTtPLSSTRG activity, induced transcription, induced 20484411 1 0 0 -Irs1 IRS1 Adaptor/scaffold; Motility/polarity/chemotaxis P35569 16367 1 C5|1 42.0 cM mouse S731-p 2352500 TGDYMNMsPVGDSNT molecular association, regulation PIK3C2A(DISRUPTS) 10092613 2 0 0 -Drd1 DRD1 GPCR, family 1; Membrane protein, integral; Membrane protein, multi-pass; Receptor, GPCR Q61616 13488 13 B1|13 28.4 cM mouse S421-p 30310300 EKLSPALsVILDYDT intracellular localization signaling pathway regulation 25304015 2 0 0 membrane localization, regulates behavioral responses to cocaine in mice. -POLR2A POLR2A EC 2.7.7.48; EC 2.7.7.6; Nucleotide Metabolism - purine; Nucleotide Metabolism - pyrimidine; Transcription initiation complex; Transferase P24928 5430 17p13.1 human K1838-ac 1883802900 SYSPASPkYTPTSPS transcription, induced 35322029 1 0 0 RCOR1 represses transcription by deacetylation of K1838 -RANBP2 RANBP2 Adaptor/scaffold; EC 5.2.1.8; EC 6.3.2.-; Ligase; Nuclear export; Nucleoporin; SUMO LIGASE; SUMO conjugating system; SUMO ligase P49792 5903 2q13 human S2280-p 452315 SALSPSKsPAKLNQS molecular association, regulation; intracellular localization BICD2(INDUCES) 26051540 1 46 1 targets BicD2 to the NE of RGP cells to induce apical nuclear migration -Ahcyl2 AHCYL2 Amino Acid Metabolism - cysteine and methionine; EC 3.3.1.1; Hydrolase; Motility/polarity/chemotaxis; Other Amino Acids Metabolism - selenoamino acid Q68FL4 74340 6|6 A3.3 mouse S151-p 4734539 RSLSRSIsQSSTDSY molecular association, regulation SLC4A4(INDUCES) 27382360 2 0 1 S149 and T172 are also involved in activation of SLCA4 -Bach2 BACH2 DNA-binding; Transcription factor P97303 12014 4|4 A5 mouse S509-p 15407975 PIKVCPRsPPLETRT intracellular localization; activity, inhibited transcription, induced 26620562 1 5 7 increased repressor activity of Bach2 S509A and Bach2 S535A mutants was observed -FPR2 FPR2 GPCR, family 1; Membrane protein, integral; Membrane protein, multi-pass; Motility/polarity/chemotaxis; Receptor, GPCR P25090 2358 19q13.41 human S329-p 19075301 ERALSEDsAPTNDTA receptor desensitization, induced 21543323 1 0 0 -CDCA8 Borealin Cell cycle regulation; Nucleolus Q53HL2 55143 1p34.3 human T230-p 4203200 DSKEIFLtVPVGGGE Borealin molecular association, regulation; protein conformation; phosphorylation cell cycle regulation; cytoskeletal reorganization Borealin(INDUCES) 18243099; 19530738 2 0 0 stimulates phosphorylation of CENPA S7; important for chromosome alignment; chromosome alignment in mitosis -IQGAP1 IQGAP1 GAP; GAP, Ras; Motility/polarity/chemotaxis P46940 8826 15q26.1 human K1155-ub 12341105 AIVSSVDkIPYGMRF RasGAP molecular association, regulation CDC42(INDUCES); RAC1(INDUCES) 32094223 1 7 3 6KR mutant compared to WT; no effect of K1155R or K1230R mutants on CDC42 or Rac binding -FOXO3 FOXO3A Autophagy; DNA-binding; Oncoprotein; Transcription factor O43524 2309 6q21 human S413-p 12084437 GLMQRSSsFPYTTKG activity, induced; phosphorylation transcription, induced; signaling pathway regulation 17711846; 31679687 5 7 2 induces phosphorylation of other sites; in glucose starvation -ZNF148 ZNF148 C2H2-type zinc finger protein; DNA-binding; Transcription, coactivator/corepressor Q9UQR1 7707 3q21.2 human K356-sm 2798307 YSSSTKVkDEYMVAE transcription, inhibited 17940278 1 2 0 -PDGFRA PDGFRA EC 2.7.10.1; KINASE; Kinase, protein; Membrane protein, integral; Oncoprotein; Protein kinase, TK; Protein kinase, tyrosine (receptor) P16234 5156 4q12 human Y849-p 448441 DIMHDSNyVSKGSTF PK_Tyr_Ser-Thr phosphorylation; enzymatic activity, induced cell differentiation, inhibited; carcinogenesis, induced; cell motility, induced; cell growth, induced; signaling pathway regulation 33626330; 34858182; 35393545 8 9 59 regulates the phosphorylation of DUSP1/p38MAPK and inhibits cell differentiation through the DUSP1/p38MAPK pathway -Ywhag 14-3-3 gamma Adaptor/scaffold P61982 22628 5|5 G2 mouse S59-p 3892745 VVGARRSsWRVISSI 14-3-3 molecular association, regulation 14-3-3 gamma(INDUCES) 25086053 2 0 8 -ABL1 Abl EC 2.7.10.2; KINASE; Kinase, protein; Oncoprotein; Protein kinase, TK; Protein kinase, tyrosine (non-receptor) P00519 25 9q34.12 human Y226-p 450303 KRNKPTVyGVSPNYD enzymatic activity, induced cell cycle regulation; cell differentiation, altered; carcinogenesis, inhibited; cell growth, inhibited; cell motility, induced 20228840; 26473374; 35569509 28 12 304 -Tgfb1i1 Hic-5 Motility/polarity/chemotaxis; Nuclear receptor co-regulator; Transcription, coactivator/corepressor Q62219 21804 7|7 F3 mouse Y60-p 450964 TGDKDHLySTVCKPR cytoskeletal reorganization 16183059 3 7 20 phosphorylation of this site after EGF induction leads to reduction of Rac activity and formation of lamellipodia -CXCR2 IL8RB GPCR, family 1; Membrane protein, integral; Membrane protein, multi-pass; Receptor, GPCR; Receptor, cytokine P25025 3579 2q35 human S347-p 451046 LPKDSRPsFVGSSSG protein degradation; receptor desensitization, altered; receptor internalization, altered 9079638 1 2 5 -CEBPA C/EBP-alpha DNA-binding; Transcription factor P49715 1050 19q13.11 human K302-ac 56394105 AVRKSRDkAKQRNVE bZIP_2 molecular association, regulation cell differentiation, inhibited; transcription, inhibited DNA(DISRUPTS) 27005833 2 0 0 -Nrip1 RIP140 Nuclear receptor co-regulator; Transcription, coactivator/corepressor Q8CBD1 268903 16|16 C3.1 mouse T202-p 456686 KDQKSGPtLPDVTPN NRIP1_repr_1 activity, induced; molecular association, regulation; acetylation; intracellular localization cell differentiation, induced; transcription, inhibited p300(INDUCES) 16093479; 18655826 2 2 0 increases acetylation of RIP140 at K158 and K287 -Etv4 ETV4 DNA-binding P28322 18612 11 D|11 65.48 cM mouse K317-ac 26373306 DVCIVPEkFEGDIKQ ETS_PEA3_N sumoylation transcription, induced 21543453 1 1 0 acetylated sites inhibits sumoylation reciprocally -SLC5A6 SLC5A6 Membrane protein, integral; Membrane protein, multi-pass; Transporter; Transporter, SLC family Q9Y289 8884 2p23.3 human T286-p 20503442 QRYLSSRtEKAAVLS SSF activity, inhibited 21570947 1 0 0 biotin uptake inhibited -Cdk16 CDK16 Cell cycle regulation; EC 2.7.11.22; KINASE; Kinase, protein; Motility/polarity/chemotaxis; Protein kinase, CMGC; Protein kinase, Ser/Thr (non-receptor) Q04735 18555 X A1.3|X 16.18 cM mouse T175-p 7445726 LDKLGEGtYATVYKG Pkinase molecular association, regulation CCNYL1(INDUCES) 26305884 1 13 14 -ORC2 ORC2 DNA replication Q13416 4999 2q33.1 human T226-p 7320974 SAPVGKEtPSKRMKR molecular association, regulation cell cycle regulation DNA(DISRUPTS) 22334659; 24732362 3 23 17 -FCAR FCAR Immunoglobulin superfamily; Membrane protein, integral P24071 2204 19q13.42 human S284-p 1870031100 LTFARTPsVCK____ molecular association, regulation; intracellular localization; activity, inhibited Ig-alpha(DISRUPTS) 30766540 1 0 0 -AURKA AurA EC 2.7.11.1; KINASE; Kinase, protein; Oncoprotein; Protein kinase, Other; Protein kinase, Ser/Thr (non-receptor) O14965 6790 20q13.2 human S342-p 457608 QETYKRIsRVEFTFP Pkinase enzymatic activity, induced cell cycle regulation; cytoskeletal reorganization 16246726 3 2 0 -KDM5B JARID1B Cancer Testis Antigen (CTA); DEMETHYLASE; Demethylase; EC 1.14.11.-; Oxidoreductase; Transcription, coactivator/corepressor Q9UGL1 10765 1q32.1 human K242-ub 38557706 RAEAMNIkIEPEETT intracellular localization; enzymatic activity, induced carcinogenesis, inhibited 25596733 1 2 0 decreases H3K4Me3 methylation, induces senescence -Adcy6 ADCY6 Adenylyl cyclase; EC 4.6.1.1; Lyase; Membrane protein, integral; Membrane protein, multi-pass; Nucleotide Metabolism - purine; Transporter; Transporter, aquaporin family AAA40678 25289 7q36 rat S674-p 455529 EDLEKKYsRKVDPRF Adcy_cons_dom enzymatic activity, inhibited 11877398; 15470083 2 0 0 decreases potentiation -CDKN2A p16-INK4A Cell cycle regulation; Nucleolus; Tumor suppressor P42771 1029 9p21.3 human R138-me 62906109 RAAAGGTrGSNHARI Ank_2 cell growth, induced; apoptosis, inhibited 28120917 1 0 0 -BCL6 Bcl-6 C2H2-type zinc finger protein; Oncoprotein; Transcription factor P41182 604 3q27.3 human K379-ac 460604 ACNWKKYkFIVLNSL molecular association, regulation HDAC2(DISRUPTS) 12402037 1 0 0 -H4c2 H4 DNA-binding P62806 326620 13|13 A3.1 mouse K8-ac 458959 SGRGKGGkGLGKGGA protein degradation cell cycle regulation; chromatin organization, altered; apoptosis, induced; transcription, induced; transcription, altered 17344422; 17530637; 17626110; 17823087; 20543957; 33087562 85 21 529 -ERGIC3 SDBCAG84 Membrane protein, integral; Membrane protein, multi-pass; Motility/polarity/chemotaxis; Vesicle Q9Y282 51614 20q11.22 human K8-ub 12317401 MEALGKLkQFDAYPK ERGIC_N protein degradation 31142615 1 8 4 trafficking and secretion of alpha1-antitrypsin and haptoglobin -ERBB2 HER2 EC 2.7.10.1; KINASE; Kinase, protein; Membrane protein, integral; Oncoprotein; Protein kinase, TK; Protein kinase, tyrosine (receptor) P04626 2064 17q12 human T1172-p 451643 ATLERPKtLSPGKNG receptor desensitization, altered 8700533 1 0 2 -GLI3 GLI3 C2H2-type zinc finger protein; Transcription factor P10071 2737 7p14.1 human S849-p 7998355 NMLNRRDsSASTISS protein processing transcription, inhibited 10693759 1 1 6 -ARRB2 ARRB2 iso2 Adaptor/scaffold P32120-2 281638 cow K400-sm 25350102 RLRLKGLkDEDYDDQ molecular association, regulation AP-2 beta(INDUCES) 21118812 1 0 0 GPCR endocytosis induced -PCM1 PCM-1 Cell cycle regulation; Oncoprotein Q15154 5108 8p22 human S372-p 11536118 RRQAESLsLTREVSQ intracellular localization; protein conformation autophagy, altered 26755742; 28712572 2 11 12 -Trpv1 TRPV1 Channel, cation; Membrane protein, integral; Membrane protein, multi-pass; Receptor, misc. Q704Y3 193034 11 B4|11 45.25 cM mouse T145-p 456216 QKSKKRLtDSEFKDP Ank_2 receptor desensitization, altered 16954222 5 0 0 -RBL1 Rb-like 1 Transcription, coactivator/corepressor; Tumor suppressor P28749 5933 20q11.23 human S975-p 450986 HIKQQPGsPRRISQQ Rb_C cell growth, altered 11884610 2 0 1 -Nek1 NEK1 EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, Other; Protein kinase, Ser/Thr (non-receptor) P51954 18004 8 B3.1|8 30.91 cM mouse T141-p 65958203 IFLTKDGtVQLGDFG Pkinase enzymatic activity, induced cell cycle regulation; carcinogenesis, induced; DNA repair, induced; cell growth, induced; apoptosis, induced; transcription, induced 30928383 3 0 0 -Gli2 GLI2 C2H2-type zinc finger protein; Oncoprotein; Transcription factor Q0VGT2 14633 1 E2.3|1 52.17 cM mouse S848-p 25352005 TDASRRSsEASQCSG sumoylation 22549777 1 1 0 -GRB10 GRB10 Adaptor/scaffold Q13322 2887 7p12.1 human S476-p 455870 MNILGSQsPLHPSTL protein stabilization; activity, inhibited 15952796; 21659604 7 16 17 -RIOK1 RIOK1 EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, Ser/Thr (non-receptor); Protein kinase, atypical Q9BRS2 83732 6p24.3 human T410-p 797986500 MEIASQRtKEERSSQ protein stabilization 29384474 1 1 0 RIOK1 phosphorylation at T410 by CK2 blocks methylation at K411 by SETD7 and stabilizes RIOK1 -TRAIP TRAIP EC 6.3.2.-; Ligase; Nucleolus; UBIQUITIN LIGASE; Ubiquitin conjugating system; Ubiquitin ligase Q9BWF2 10293 3p21.31 human K80-sm 53529104 VLDAEFLkNELDNVR protein stabilization; ubiquitination; intracellular localization 26820530 2 0 0 inhibits ubiquitination -NCL NCL DNA-binding; Helicase; Nuclear receptor co-regulator; Nucleolus; RNA-binding P19338 4691 2q37.1 human S34-p 466005 DSEDEEMsEDEEDDS intracellular localization cell cycle regulation; cell growth, induced 25313645 3 42 9 -BAG2 BAG2 Apoptosis O95816 9532 6p12.1 human K186-ub 21129790 RNIENSDkAIKLLEH BAG protein degradation; molecular association, regulation apoptosis, induced LOXL1(DISRUPTS) 32424143 1 5 0 -NOS3 eNOS Amino Acid Metabolism - arginine and proline; EC 1.14.13.39; Oxidoreductase P29473 287024 cow T497-p 447885 AGITRKKtFKEVANA molecular association, regulation; enzymatic activity, inhibited Calmodulin(INDUCES) 11292821; 12869534; 12952971; 26987903; 34474112 82 2 1 -RELA NFkB-p65 DNA-binding; Nuclear receptor co-regulator; Transcription factor Q04206 5970 11q13.1 human S468-p 451145 AVFTDLAsVDNSEFQ activity, induced; protein degradation; molecular association, regulation; ubiquitination; intracellular localization; activity, inhibited carcinogenesis, induced; carcinogenesis, inhibited; cell growth, inhibited; apoptosis, induced; cell motility, induced; transcription, induced; transcription, altered; apoptosis, inhibited; transcription, inhibited COMMD1(INDUCES); CUL2(INDUCES) DNA(INDUCES) 15465828; 16046471; 16407239; 18201972; 19270718; 20188669; 20507904; 33459422; 34082140; 34674717; 35779404; 35890077; 35950917 22 0 0 -Oprd1 DOR-1 GPCR, family 1; Membrane protein, integral; Membrane protein, multi-pass; Receptor, GPCR P32300 18386 4 D2.3|4 64.78 cM mouse T161-p 455533 VKALDFRtPAKAKLI 7tm_1 receptor desensitization, altered 11861651 3 0 0 -YAP1 YAP1 Oncoprotein; Transcription, coactivator/corepressor P46937 10413 11q22.1 human S127-p 448847 PQHVRAHsSPASLQL activity, induced; protein degradation; molecular association, regulation; ubiquitination; intracellular localization; activity, inhibited; phosphorylation cell cycle regulation; carcinogenesis, induced; apoptosis, altered; cell motility, induced; apoptosis, induced; cell motility, inhibited; signaling pathway regulation; cell differentiation, altered; cell growth, induced; cell motility, altered; transcription, inhibited; cell growth, altered; cell differentiation, inhibited; carcinogenesis, altered; carcinogenesis, inhibited; cell growth, inhibited; transcription, induced; transcription, altered; autophagy, induced; cell differentiation, induced; apoptosis, inhibited; cytoskeletal reorganization; cell adhesion, altered 14-3-3 sigma(INDUCES); 14-3-3 zeta(INDUCES); 14-3-3 eta(INDUCES); p73(DISRUPTS); 14-3-3 beta(INDUCES); 53BP2(INDUCES); TEAD1(DISRUPTS); AML2(INDUCES); CTNNB1(INDUCES) DNA(DISRUPTS) 12535517; 18640976; 20153295; 20729916; 20823509; 21666719; 21730131; 21945154; 22234184; 24362629; 24658687; 24803537; 25360797; 25362852; 25373897; 25601544; 25605730; 25739674; 25772246; 26039999; 26265440; 26364602; 26549256; 26598551; 27425596; 28171658; 28273460; 28416665; 28474680; 28775168; 28793266; 31239271; 31988076; 32053631; 32064037; 32205868; 32271880; 32929029; 33162394; 33536280; 33545120; 33552953; 33622361; 33630828; 33990468; 34058200; 34129887; 34206989; 34462276; 34465890; 34482636; 34516278; 34593639; 34663879; 34743733; 34874746; 35000271; 35027733; 35065073; 35102250; 35172140; 35210364; 35307353; 35440025; 35452623; 35586495; 35713503; 35731019; 35761037; 35773411; 35780183; 35858343; 35882980; 36001958; 36015285; 36044856; 36115593; 36318920; 36346780; 36369000; 36588499; 36622276; 36640330; 36643034; 36747492; 36774339; 36823643; 37100374; 37319316 207 33 180 -Dnm2 DYN2 EC 3.6.5.5; Hydrolase; Microtubule-binding; Motility/polarity/chemotaxis; Vesicle P39054 13430 9 A3|9 7.79 cM mouse Y597-p 451200 NTEQRNVyKDLRQIE PH cytoskeletal reorganization 21411625 5 1 2 promotes focal adhesion turnover -SORT1 SORT1 Membrane protein, integral; Receptor, misc. Q99523 6272 1p13.3|1p21.3-p13.1 human S825-p 468808 KSGYHDDsDEDLLE_ protein stabilization; molecular association, regulation GGA1(INDUCES) 20015111; 25805502 5 43 23 -AURKB AurB EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, Other; Protein kinase, Ser/Thr (non-receptor) Q96GD4 9212 17p13.1 human K215-ac 54468601 LGLKGELkIADFGWS Pkinase molecular association, regulation; phosphorylation; enzymatic activity, induced cell cycle regulation PPP2CA(DISRUPTS) 26829474 1 1 0 -POLI POLI DNA repair, damage; EC 2.7.7.7; Transferase Q9UNA4 11201 18q21.2 human K533-ub 50771307 GVDQEVFkQLPVDIQ protein degradation 26370087 1 1 0 -WWC1 KIBRA Adaptor/scaffold Q8IX03 23286 5q34 human S539-p 20751200 TSLSPRSsLSSPSPP molecular association, regulation cell cycle regulation Merlin(INDUCES) 21878642; 22904328 3 0 0 -TLE1 TLE1 Nuclear receptor co-regulator; Transcription, coactivator/corepressor Q04724 7088 9q21.32 human S286-p 5707650 LKKDASSsPASTASS molecular association, regulation transcription, induced DNA(NOT_REPORTED) 19956621; 24270405 2 24 1 -Pgr PR DNA-binding; Nuclear receptor; Transcription factor Q00175 18667 9|9 A1 mouse S294-p 447987 SPIAPGRsPLATTVV Prog_receptor activity, induced; phosphorylation transcription, altered MSK1(INDUCES); ERK2(INDUCES); ERK1(INDUCES) 17081988 21 3 0 -SNRPB snRNP B1 RNA processing; RNA splicing; RNA-binding; Spliceosome P14678 6628 20p13 human R209-m2 476758 PMGIPPGrGTPMGMP molecular association, regulation SMN(INDUCES) 11720283 1 1 0 -CCNE2 CCNE2 Activator; Cell cycle regulation O96020 9134 8q22.1 human S396-p 4271425 GIMTPPKsTEKPPGK protein degradation; ubiquitination 19084516 1 0 1 -Epor EPOR Membrane protein, integral; Receptor, cytokine P14753 13857 9 A3|9 7.93 cM mouse Y367-p 449883 SEHAQDTyLVLDKWL molecular association, regulation carcinogenesis, induced; apoptosis, altered; cell differentiation, altered; cell growth, induced; cell growth, altered PLCG1(INDUCES) 11806992; 15953601; 16380376; 20028972; 27998978; 7541671; 8521813 17 0 0 activates Stat5 -BORA BORA Activator Q6PGQ7 79866 13q21.33 human S252-p 7533203 SSGQFSSsPIQASAK molecular association, regulation cell cycle regulation PLK1(INDUCES) 18521620; 34759346 2 4 1 -SRCIN1 SNIP Cytoskeletal Q9C0H9 80725 17q12 human Y396-p 456704 LVKGEGLyADPYGLL molecular association, regulation CSK(INDUCES) 23383002 1 18 217 -Rbpms RBPMS Motility/polarity/chemotaxis Q9WVB0 19663 8|8 A4 mouse T118-p 3208560 VGTPNPStPLPNTVP molecular association, regulation; activity, inhibited; phosphorylation RBPMS(DISRUPTS) RNA(DISRUPTS) 36408906 2 10 2 primes phosphorylation at T113 -IL6ST gp130 Membrane protein, integral; Receptor, cytokine P40189 3572 5q11.2 human S782-p 448180 QVFSRSEsTQPLLDS receptor internalization, induced; protein degradation; receptor internalization, altered transcription, inhibited; signaling pathway regulation 10811661; 15786731; 22306348 4 5 0 -Prkdc DNAPK DNA repair, damage; EC 2.7.11.1; KINASE; Kinase, protein; Nucleolus; Protein kinase, Ser/Thr (non-receptor); Protein kinase, atypical P97313 19090 16 10.09 cM|16 A2 mouse T2605-p 448710 LTPMFIEtQASPSIL DNAPKcs_CC5 DNA repair, induced 37307443 36 8 22 contributes to the synergy between XLF and DNA-PKcs in end-ligation, sites have distinct moderate roles in NHEJ -Prkch PKCH EC 2.7.11.13; KINASE; Kinase, protein; Protein kinase, AGC; Protein kinase, Ser/Thr (non-receptor) P23298 18755 12|12 C3 mouse S642-p 1239966008 IKSREDVsNFDPDFI Pkinase_C phosphorylation cell differentiation, induced; transcription, inhibited 30154443 1 0 0 inhibits transcription of E-cadherin, induces phosphorylation of Klf4 -Unc93b1 UNC93B1 Cell surface; Membrane protein, integral; Membrane protein, multi-pass Q8VCW4 54445 19|19 A mouse S550-p 3212118 EEDNSDEsDMEGEQG molecular association, regulation signaling pathway regulation syntenin(INDUCES) 31546246 1 25 4 inhibits TLR7 signaling -FAM50A FAM50A DNA-binding Q14320 9130 Xq28 human K5-m1 57984718 ___MAQYkGAASEAG molecular association, regulation L3MBTL iso4(INDUCES) 23583077 0 3 0 -Camk2a CAMK2A EC 2.7.11.17; KINASE; Kinase, protein; Protein kinase, CAMK; Protein kinase, Ser/Thr (non-receptor) P11798 12322 18 E1|18 34.41 cM mouse T337-p 481032 SSESTNTtIEDEDTK molecular association, regulation; enzymatic activity, inhibited NMDAR2B(DISRUPTS); Calmodulin(DISRUPTS) 28636948 1 10 12 regulates LTP, fear memory, spatial learning -TUBA1A TUBA1A Cytoskeletal; Motility/polarity/chemotaxis Q71U36 7846 12q13.12 human K96-sm 55461538 PEQLITGkEDAANNY Tubulin sumoylation cytoskeletal reorganization 33394042 1 2 0 promotes microtubule catastrophe, attenuates MT polymerization, facilitates neurite extension -PFKFB3 PFKFB3 Carbohydrate Metabolism - fructose and mannose; EC 2.7.1.105; EC 3.1.3.46; KINASE; Kinase, other; Motility/polarity/chemotaxis; PHOSPHATASE; Phosphatase (non-protein) Q16875 5209 10p15.1 human S467-p 468406 NSVTPLAsPEPTKKP cell growth, induced 29967256 2 27 30 CDK6 phosphorylation of PFKFB3 may regulate glucose metabolism and be involved in breast cancer -Itpr2 IP3R2 Channel, calcium; Channel, ligand-gated; Membrane protein, integral; Membrane protein, multi-pass P29995 rat S150-p 26415703 EKNAMRVsLDAAGNE Ins145_P3_rec activity, inhibited 23019322 1 0 0 phosphorylation channel modulation (open probability is decreased) -HNRNPK hnRNP K RNA splicing; RNA-binding; Spliceosome P61978 3190 9q21.32 human S353-p 450147 DSAIDTWsPSEWQMA activity, induced; intracellular localization translation, altered; cell growth, induced; transcription, induced; transcription, altered 11231586; 11259409; 24236111 4 1 0 localized to nuclear matrix -EIF4EBP1 4E-BP1 Translation; Translation initiation Q13541 1978 8p11.23 human S83-p 447525 PTIPGVTsPSSDEPP eIF_4EBP intracellular localization carcinogenesis, induced 27402756 7 9 0 colocalizes with centrosomes during mitosis, cell transformation -Mafa MAFA DNA-binding; Oncoprotein; Transcription factor; Tumor suppressor Q8CF90 378435 15|15 D3 mouse S49-p 1320400 CHRLPPGsLSSTPLS protein degradation; molecular association, regulation transcription, inhibited MAFA(INDUCES); PSME3(INDUCES) DNA(NOT_REPORTED) 20208071; 21646385 4 1 0 -RSF1 HBXAP Transcription, coactivator/corepressor Q96T23 51773 11q14.1 human S1375-p 3088513 LPSTNGQsPGKAIEN phosphorylation cell cycle regulation 26259146 1 50 4 phosphorylation of this site facilitates the subsequent phosphorylation by Plk1 at S1359; plays a role in PLK1 recruitment and deposition on mitotic kinetochores -GCSAM GCET2 Unknown function Q8N6F7 257144 3q13.2 human Y128-p 463674 LGGTETEySLLHMPS HGAL activity, induced signaling pathway regulation 31362927 3 2 1 regulates B cell receptor signaling -CCNT1 CCNT1 Cell cycle regulation; Transcription initiation complex O60563 904 12q13.11-q13.12 human K404-ac 9263557 AEELAAQkRQLENME molecular association, regulation; enzymatic activity, induced transcription, induced BCDIN3(DISRUPTS); HEXIM1(DISRUPTS); BRD4(INDUCES) 19387490; 19828451 2 1 2 enhances CDK9/cyclin T1 transcriptional activity, disrupting HEXIM1 and BCDIN3 association -Trim28 TIF1B EC 6.3.2.-; KINASE; Kinase, protein; Ligase; Nuclear receptor co-regulator; Protein kinase, atypical; SUMO LIGASE; SUMO ligase; Transcription, coactivator/corepressor; UBIQUITIN LIGASE; Ubiquitin conjugating system; Ubiquitin ligase Q62318 21849 7|7 A1 mouse K804-sm 2798311 NDAFGDTkFSAVLVE transcription, inhibited 17298944 5 4 0 -FAS FAS Apoptosis; Cell surface; Membrane protein, integral; Receptor, cytokine P25445 355 10q23.31 human Y291-p 455222 LHGKKEAyDTLIKDL Death molecular association, regulation; intracellular localization apoptosis, altered FAS(INDUCES); FADD(INDUCES); CASP8(INDUCES) 15660394; 17195092 3 0 0 Y291 or Y232 is required for Fas oligomerization -TTK TTK Cancer Testis Antigen (CTA); EC 2.7.12.1; KINASE; Kinase, protein; Protein kinase, Other; Protein kinase, dual-specificity (non-receptor) P33981 7272 6q14.1 human K287-sm 52485003 NSPDCDVkTDDSVVP molecular association, regulation cell cycle regulation BUB1B(DISRUPTS) 26675261 1 0 0 -Siah2 SIAH2 EC 6.3.2.-; EC 6.3.2.19; Ligase; Transcription, coactivator/corepressor; UBIQUITIN LIGASE; Ubiquitin conjugating system; Ubiquitin ligase Q06986 20439 3 D|3 28.68 cM mouse T24-p 471340 KQPPPPQtPHAPSPA molecular association, regulation; intracellular localization EGLN3(INDUCES) 17003045 1 0 0 plays a role in degradation of endogenous EGLN3 (PHD3). -MAP4 MAP4 Cytoskeletal; Motility/polarity/chemotaxis P27816 4134 3p21.31 human K912-ac 62495527 DKKPTSAkPSSTTPR cytoskeletal reorganization 28002468 1 1 0 -KDM5B JARID1B Cancer Testis Antigen (CTA); DEMETHYLASE; Demethylase; EC 1.14.11.-; Oxidoreductase; Transcription, coactivator/corepressor Q9UGL1 10765 1q32.1 human K242-sm 31089530 RAEAMNIkIEPEETT molecular association, regulation; enzymatic activity, induced transcription, induced DNA(DISRUPTS) 23970103 1 2 0 regulates JARID1B demethylase activity -HRC HRC Calcium-binding; Contractile P23327 3270 19q13.33 human S96-p 34499322 EKEDEDVsKEYGHLL molecular association, regulation SERCA2(INDUCES); TRDN(INDUCES) 28784772 2 4 0 -CDC5L CDC5L DNA-binding; Motility/polarity/chemotaxis; RNA processing; RNA splicing; Spliceosome; Transcription factor Q99459 988 6p21.1 human T438-p 3210129 PKPVINStPGRTPLR Myb_Cef RNA splicing, altered 18583928 1 8 28 -ASB8 ASB8 Q9H765 140461 12q13.11 human S31-p 1868140200 RTIAAIRsFPHDNVE Ank_2 ubiquitination signaling pathway regulation 31009856 1 1 0 induces ubiquitination of IKKB; regulates NF-kB signaling pathway -DNER DNER Membrane protein, integral; Receptor, misc. Q8NFT8 92737 2q36.3 human Y721-p 473325 SPIAYEDySPDDKPL DNER_C intracellular localization 18474614 1 1 10 -ATP7A ATP7A Apoptosis; Cell development/differentiation; Chaperone; EC 3.6.3.54; Hydrolase; Membrane protein, integral; Membrane protein, multi-pass; Transporter; Transporter, ion channel; Vesicle Q04656 538 Xq21.1 human S1463-p 4733422 IVNYSRAsINSLLSD protein stabilization; intracellular localization 29301787 2 18 2 translocation to membrane -Tlr3 TLR3 Membrane protein, integral; Receptor, cytokine Q7TNI8 364594 16q11 rat Y760-p 450187 EQFEYTAyIIHAQKD TIR cell growth, induced; transcription, induced 24526685 4 0 0 -PIK3R1 PIK3R1 KINASE; Kinase, lipid; Motility/polarity/chemotaxis P23727 282307 cow T86-p 22881800 RKKISPPtPKPRPPR molecular association, regulation IRS1(DISRUPTS) 22158866 1 1 0 -MT-CO1 COX1 EC 1.9.3.1; Energy Metabolism - oxidative phosphorylation; Membrane protein, integral; Membrane protein, multi-pass; Mitochondrial; Oxidoreductase P00395 4512 - human K264-ac 1879877107 IVTYYSGkKEPFGYM apoptosis, induced 31647884 1 0 0 mutant sites were found to significantly suppressed the AAPH-evoked increase in both ROS level and apoptosis -THRB TR-beta1 DNA-binding; Nuclear receptor P10828 7068 3p24.2 human S142-p 449635 IQKNLHPsYSCKYEG zf-C4 molecular association, regulation transcription, altered SMRT(DISRUPTS); p300(INDUCES) 12809513 1 0 0 -IKBKB IKKB EC 2.7.11.10; KINASE; Kinase, protein; Protein kinase, Other; Protein kinase, Ser/Thr (non-receptor) O14920 3551 8p11.21 human S733-gl 6729303 TVREQDQsFTALDWS IKKbetaNEMObind carcinogenesis, induced 19202066 1 0 0 enhanced in transformed human fibroblasts, enhanced glucose metabolism -Asap1 DDEF1 GAP; GAP, ARF; Motility/polarity/chemotaxis Q9QWY8 13196 15|15 D1 mouse Y782-p 450438 RDKQRLSyGAFTNQI molecular association, regulation; activity, inhibited Other(DISRUPTS) 12771146; 16413287 5 0 0 modulates DDEF1 phospholipid binding as well as ARF1 GTPase activity; leads to less binding to phospholipids (including P(4,5)P2, PI(3,4,5)P3, and PI(3,4)P2) and less GAP activity toward Arf1 -KLF4 KLF4 C2H2-type zinc finger protein; DNA-binding; Transcription factor O43474 9314 9q31.2 human K278-sm 14988613 PRTCPKIkQEAVSSC cell differentiation, induced; transcription, inhibited 23515309 2 0 0 -MAGEA11 MAGE-A11 Cancer Testis Antigen (CTA); Transcription, coactivator/corepressor P43364 4110 Xq28 human K240-ub 2028408 LLRKYRVkGLITKAE MAGE protein degradation; molecular association, regulation; ubiquitination transcription, induced MAGE-A6(DISRUPTS) 23853093; 28542476 3 0 0 induce activation of E2F1; MageA6 interaction with MageA11 prevents MageA11 ubiquitination -Psmb3 PSMB3 Cell cycle regulation; EC 3.4.25.1; Protease; Proteasome complex Q9R1P1 26446 11 D|11 61.07 cM mouse K77-ac 475744 RLNLYELkEGRQIKP Proteasome protein degradation 24037710 0 8 9 -IKBKB IKKB EC 2.7.11.10; KINASE; Kinase, protein; Protein kinase, Other; Protein kinase, Ser/Thr (non-receptor) O14920 3551 8p11.21 human S258-p 31849417 GTVKFSSsLPYPNNL Pkinase protein degradation; ubiquitination carcinogenesis, induced; cell growth, induced 36923932 1 1 0 -GTF2I GTF2I DNA-binding; Transcription, coactivator/corepressor P78347 2969 7q11.23 human S412-p 457074 GIPFRRPsTYGIPRL GTF2I transcription, induced 12082086 2 11 139 -NDUFV1 NDUFV1 EC 1.6.5.3; EC 1.6.99.3; Energy Metabolism - oxidative phosphorylation; Mitochondrial; Oxidoreductase P49821 4723 11q13.2 human T383-p 33402200 HESCGQCtPCREGVD NADH_4Fe-4S activity, induced cell cycle regulation 24746669 1 1 0 increases mitochondrial respiration for G/2M transition -LATS1 LATS1 EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, AGC; Protein kinase, Ser/Thr (non-receptor); Tumor suppressor O95835 9113 6q25.1 human S464-p 451855 NIPVRSNsFNNPLGN protein degradation 19927127 1 50 9 -Npas4 NPAS4 DNA-binding Q8BGD7 225872 19|19 A mouse S615-p 1871095701 GLLTPEAsPVKQSFF molecular association, regulation neural plasticity; transcription, induced CBP(INDUCES) 31801086 1 1 0 -PARP1 PARP1 DNA repair, damage; EC 2.4.2.30; Nuclear envelope; Nuclear receptor co-regulator; Nucleolus; Transferase P09874 142 1q42.12 human K498-ac 459000 EVVAPRGkSGAALSK molecular association, regulation transcription, induced NFkB-p105(INDUCES) 16204234 1 1 0 -SNAPIN SNAPIN Vesicle O95295 23557 1q21.3 human S50-p 448453 HVHAVREsQVELREQ Snapin_Pallidin molecular association, regulation neural plasticity; exocytosis, induced RAPGEF4(INDUCES); VAMP2(INDUCES); TMEM27(INDUCES); SNAP-25(INDUCES) 15269257; 21356520 5 0 0 -PTK2 FAK EC 2.7.10.2; KINASE; Kinase, protein; Protein kinase, TK; Protein kinase, tyrosine (non-receptor) Q05397 5747 8q24.3 human T700-p 485788 MESRRQAtVSWDSGG phosphorylation; enzymatic activity, induced cell motility, induced; cell adhesion, inhibited 23264741 1 2 1 induces phosphorylation at S695 -PLK3 PLK3 EC 2.7.11.21; KINASE; Kinase, protein; Nucleolus; Protein kinase, Other; Protein kinase, Ser/Thr (non-receptor) Q9H4B4 1263 1p34.1 human T219-p 1869357200 PPEQRKKtICGTPNY Pkinase enzymatic activity, inhibited 32575753 1 0 0 -STXBP1 STXBP1 Vesicle P61764 6812 9q34.11 human S313-p 448744 SLKDFSSsKRMNTGE Sec1 molecular association, regulation exocytosis, induced STX1A(DISRUPTS) 25716318; 28983637 7 0 0 reduced vesicle association ; mast cell degranulation -RAD17 RAD17 Cell cycle regulation O75943 5884 5q13.2 human S359-p 23136916 RPRKKGMsLKSDAVL molecular association, regulation RAD1(INDUCES) 29902452 1 1 6 -HMGB1 HMGB1 DNA repair, damage; Nuclear receptor co-regulator P09429 3146 13q12.3 human K112-me 31094520 FCSEYRPkIKGEHPG HMG_box intracellular localization 24289579 1 1 0 localized to the cytoplasm -CSNK1A1 CK1A EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, CK1; Protein kinase, Ser/Thr (non-receptor) P48729 1452 5q32 human T169-p 1876579500 KKYRDNRtRQHIPYR Pkinase phosphorylation; enzymatic activity, induced carcinogenesis, induced; cell growth, induced; transcription, induced; signaling pathway regulation 35277657 1 0 0 induces QIK phosphorylation thereby inducing the Wnt/?-catenin signaling pathway -SLFN12 SLFN12 Unknown function Q8IYM2 55106 17q12 human S368-p 1876351800 TSLPAPHsWPLLEWQ enzymatic activity, inhibited RNA stability, induced 35104454 1 1 0 -Sgo2a SGOL2 Unknown function Q7TSY8 68549 1 C1.3|1 28.86 cM mouse T521-p 27462598 LSKPSRQtFVIRKSE intracellular localization 28502659 1 1 0 dissociation from chromosome arms -Psmd11 PSMD11 Protease; Proteasome complex Q8BG32 69077 11|11 B5 mouse S14-p 468525 VEFQRAQsLLSTDRE RPN6_N activity, induced; enzymatic activity, induced transcription, altered 30782827; 37641975 3 47 30 Increases proteosome activity; induces protease activities, decreases ubiquitin conjugates, induces degradation of misfolded proteins -Vim Vimentin Cytoskeletal; Motility/polarity/chemotaxis P20152 22352 2 A1|2 10.04 cM mouse S56-p 451514 SRSLYSSsPGGAYVT Filament_head molecular association, regulation carcinogenesis, induced; cell motility, induced Vimentin(DISRUPTS); PLK1(INDUCES) 16260496; 32193336 32 85 227 -USP16 USP16 DEUBIQUITINASE; EC 3.4.19.12; Protease; Ubiquitin conjugating system; Ubiquitin-specific protease Q9Y5T5 10600 21q21.3 human S552-p 449274 DLEVLTSsPTRNLNG UCH protein degradation; molecular association, regulation; intracellular localization cell cycle regulation PLK1(INDUCES); Exportin-1(DISRUPTS) 24013421; 26323689; 28380042 3 22 2 -IGF1R IGF1R EC 2.7.10.1; KINASE; Kinase, protein; Membrane protein, integral; Protein kinase, TK; Protein kinase, tyrosine (receptor) P08069 3480 15q26.3 human Y1281-p 450102 FREVSFYySEENKLP apoptosis, altered; cell differentiation, altered; cell growth, altered 10786694; 8972223 5 0 0 -ASAP3 DDEFL1 GAP; GAP, ARF; Motility/polarity/chemotaxis Q8TDY4 55616 1p36.12 human T545-p 181213000 HRFARRCtPEPQRLW molecular association, regulation; intracellular localization DDEFL1(INDUCES) 28808054 1 0 0 tubulovesicle and relocation of H,K-ATPase to the apical plasma membrane -PCSK7 PCSK7 EC 3.4.21.-; Membrane protein, integral; Protease Q16549 9159 11q23.3 human S505-p 1827354800 AIPQSPRsLEVLWNV protein stabilization 31945259 1 0 0 decreases TG levels -STK11 LKB1 Autophagy; EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, CAMK; Protein kinase, Ser/Thr (non-receptor); Tumor suppressor Q15831 6794 19p13.3 human T185-p 11454701 KPGNLLLtTGGTLKI Pkinase enzymatic activity, induced 12805220 1 0 0 STRAD increases LKB1 activation -Pth1r PTHR GPCR, family 2; Membrane protein, integral; Membrane protein, multi-pass; Receptor, GPCR P25961 56813 8q32 rat S504-p 2853101 GPMVSHTsVTNVGPR receptor internalization, altered; activity, inhibited 11773434; 18577695 3 1 0 -Map3k12 DLK EC 2.7.11.25; KINASE; Kinase, protein; Protein kinase, Ser/Thr (non-receptor); Protein kinase, TKL Q60700 26404 15|15 F3 mouse T43-p 4727854 CTPEKDLtPTQCVLR protein stabilization 23979718 1 5 0 -HDAC1 HDAC1 DEACETYLASE; Deacetylase; EC 3.5.1.98; Hydrolase; Nuclear receptor co-regulator Q13547 3065 1p35.2-p35.1 human S421-p 447912 IACEEEFsDSEEEGE molecular association, regulation; enzymatic activity, induced SIN3A(INDUCES) 11602581 1 71 40 -MAF1 MAF1 Transcription regulation Q9H063 84232 8q24.3 human S60-p 3211917 PHVLEALsPPQTSGL Maf1 activity, inhibited transcription, induced 20233713; 20516213 2 16 0 -TRPC4 TRPC4 Channel, calcium; Membrane protein, integral; Membrane protein, multi-pass Q9UBN4 7223 13q13.3 human Y959-p 456713 EEDSSIDyDLNLPDT activity, induced; intracellular localization NHERF(INDUCES) 16144838; 21427121 2 1 0 -Jup CTNNG Cytoskeletal; Motility/polarity/chemotaxis Q02257 16480 11 D|11 63.47 cM mouse S665-p 2048381 PDYRKRVsVELTNSL cell adhesion, induced 32841221 2 35 0 -Pla2g6 PLA2G6 EC 3.1.1.4; Lipid Metabolism - alpha-linolenic acid; Lipid Metabolism - arachidonic acid; Lipid Metabolism - ether lipid; Lipid Metabolism - glycerophospholipid; Lipid Metabolism - linoleic acid; Phospholipase P97570 360426 7q34 rat Y672-p 15512800 AMTEIHEyNQDMIRK molecular association, regulation Calnexin(INDUCES) 20732873 1 1 0 enzymatic activity of PLA2G6 increases upon incubation with calnexin -Pln PLB Inhibitor; Membrane protein, integral P61014 18821 10|10 B3 mouse T17-p 448115 SAIRRAStIEMPQQA Phospholamban activity, induced 11861420; 15276030; 21888910; 33941260 75 12 63 induces SERCA2A activity; induces SERCA activity; regulates myocyte contraction and relaxation.; increase in calcium spark frequency and size -Mapk7 ERK5 EC 2.7.11.24; KINASE; Kinase, protein; Protein kinase, CMGC; Protein kinase, Ser/Thr (non-receptor) Q9WVS8 23939 11|11 B2 mouse T219-p 448205 AEHQYFMtEYVATRW Pkinase carcinogenesis, induced; cell adhesion, induced; signaling pathway regulation 33687949 20 2 31 ERK5/ P70S6K/RAC1 pathway -TBX22 TBX22 DNA-binding Q9Y458 50945 Xq21.1 human K271-sm 2798304 NQQITKLkIERNPFA T-box transcription, inhibited 17846996 1 0 0 -ZIC3 ZIC3 C2H2-type zinc finger protein; DNA-binding; Transcription factor O60481 7547 Xq26.3 human K248-sm 31094500 RYMRQPIkQELSCKW zf_ZIC intracellular localization 23872418 1 0 0 -NF2 Merlin Cytoskeletal; Motility/polarity/chemotaxis; Tumor suppressor P35240 4771 22q12.2 human K274-ub 1878191200 SDKEFTIkPLDKKID molecular association, regulation; intracellular localization LATS1(DISRUPTS) 30918126 1 1 0 K63 kinked -Hmgb1 HMGB1 DNA repair, damage; Nuclear receptor co-regulator P63159 25459 19q12 rat K82-ac 460592 MKTYIPPkGETKKKF phosphorylation DNA(INDUCES) 19166815; 21647302 5 4 0 acetylated residues inhibit it's phosphorylation -CAPZB CAPZB iso1 Actin-binding; Motility/polarity/chemotaxis P47756-1 832 1p36.13 human S226-p 27445587 DMENKIRsTLNEIYF F_actin_cap_B cell motility, induced; cell adhesion, induced; cytoskeletal reorganization 32771000 1 2 0 -STIL STIL Cell cycle regulation; Cell development/differentiation; Oncoprotein Q15468 6491 1p33 human S395-p 23149233 MPIHDHDsGVEDEDF STIL_N protein degradation; molecular association, regulation; ubiquitination BTRC(INDUCES) 29445034 1 6 5 -MYC Myc DNA-binding; Nucleolus; Oncoprotein; Transcription factor P01106 4609 8q24.21 human K386-ac 458887 RQRRNELkRSFFALR HLH molecular association, regulation ZBTB17(INDUCES) 16126174 2 2 0 induces association with ZBTB17 on specific target promoters -Pxn PXN Adaptor/scaffold; Cell adhesion; Cytoskeletal; Motility/polarity/chemotaxis Q8VI36 19303 5 F|5 56.1 cM mouse T572-p 465506 LKQLNKGtFKEQNDK LIM cytoskeletal reorganization; cell adhesion, altered 20388733 1 1 0 leads to depolymerization of the actin cytoskeleton and activation of LFA-1 integrins -Rdx Radixin Cytoskeletal; Motility/polarity/chemotaxis P26043 19684 9|9 A5.3 mouse T564-p 448374 AGRDKYKtLRQIRQG ERM_C molecular association, regulation; intracellular localization cell motility, altered; cytoskeletal reorganization Radixin(INDUCES) 19890007; 19913059; 24250818; 9456324 21 7 16 iincreased filopodia with phosphorylated ERM proteins; membrane protrusion -Gabrb1 GABRB1 Channel, chloride; Channel, ligand-gated; Membrane protein, integral; Membrane protein, multi-pass; Transporter; Transporter, ion channel P50571 14400 5 C3.2|5 38.18 cM mouse S434-p 450244 GRIRRRAsQLKVKIP Neur_chan_memb receptor desensitization, altered 14684872 7 1 0 GABRB3 S432 demonstrated to play no noticeable role in the desensitization via PKA. -Mapt Tau ACETYLTRANSFERASE; Acetyltransferase; Cytoskeletal P10637 17762 11 67.79 cM|11 E1 mouse S688-p 449081 GAEIVYKsPVVSGDT molecular association, regulation; intracellular localization; protein conformation; phosphorylation neural plasticity SNCA(INDUCES) 21445308; 24653715; 27834631; 31645758; 34453977; 35668361 192 49 90 -MAT2A MAT2A Amino Acid Metabolism - cysteine and methionine; EC 2.5.1.6; Other Amino Acids Metabolism - selenoamino acid; Transferase P31153 4144 2p11.2 human K394-sm 50455002 WEVPKKLkY______ protein stabilization; molecular association, regulation cell growth, induced; apoptosis, inhibited; transcription, induced Bcl-2(INDUCES) DNA(INDUCES) 26416353 1 0 0 -H2AX H2AX DNA repair, damage; DNA-binding; Helicase P16104 3014 11q23.3 human K134-m2 37036405 KAPSGGKkATQASQE molecular association, regulation; phosphorylation carcinogenesis, induced ATM(INDUCES) 25487737 1 1 0 increases phosphorylation at H2AX at S139 -SPTA1 SPTA1 Cytoskeletal; Motility/polarity/chemotaxis P02549 6708 1q23.1 human Y1499-p 6211807 ERTKLGDyANLKQFY cytoskeletal reorganization 20206558 1 1 0 -A1cf ACF Hydrolase; RNA processing; RNA-binding Q923K9 170912 1q52 rat S154-p 473053 KKREEILsEMKKVTE RRM_1 activity, induced 17229474 1 0 0 enhances ApoB mRNA editing -MAP2K1 MEK1 EC 2.7.12.2; KINASE; Kinase, protein; Protein kinase, STE; Protein kinase, dual-specificity (non-receptor) Q02750 5604 15q22.31 human K104-sm 35480410 KLIHLEIkPAIRNQI Pkinase molecular association, regulation; enzymatic activity, inhibited cell differentiation, inhibited; cell growth, inhibited; signaling pathway regulation ERK2(DISRUPTS) 21336309 1 1 0 downregulates ERK signaling -Tacc3 TACC3 Cell cycle regulation Q9JJ11 21335 5|5 B2 mouse S347-p 474537 ESAWRKQsLYVKFDP intracellular localization cell cycle regulation 20838383 12 15 43 -NFE2L2 NRF2 DNA-binding; Transcription factor Q16236 4780 2q31.2 human S356-p 18258502 NTSPSVAsPEHSVES protein degradation; molecular association, regulation BTRC(DISRUPTS) 22751928; 32295843 3 1 0 -BMAL1 BMAL1 DNA-binding; Transcription factor O00327 406 11p15.3 human T21-p 12575204 DFMSPGPtDLLSSSL protein degradation transcription, altered 20049328 1 0 0 stabilization of BMAL1 protein leads to reduction in its transcription activation ability -Kcnab2 Kv-beta2 Channel, potassium P62483 29738 5q36 rat S31-p 3996100 IYSTRYGsPKRQLQF activity, induced; molecular association, regulation; intracellular localization EB1(DISRUPTS) 21357749 2 2 0 -FUS hnRNP P2 DNA-binding; Nuclear receptor co-regulator; Oncoprotein; RNA splicing; RNA-binding; SUMO LIGASE P35637 2521 16p11.2 human T11-p 179463706 NDYTQQAtQSYGAYP molecular association, regulation 28942918 2 1 0 strongly reduced the effects of DNA-PK treatment on both hydrogel binding and droplet formation -KIF2C KIF2C Cancer Testis Antigen (CTA); Microtubule-binding; Motility/polarity/chemotaxis; Motor Q99661 11004 1p34.1 human S111-p 25159900 KESLRSRsTRMSTVS molecular association, regulation; intracellular localization; activity, inhibited cytoskeletal reorganization EB1(DISRUPTS) 14960279; 19632184; 23055517 3 2 6 involved in microtubule tip tracking -CHEK1 Chk1 EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, CAMK; Protein kinase, Ser/Thr (non-receptor); Tumor suppressor O14757 1111 11q24.2 human S301-p 465528 IQSNLDFsPVNSASS intracellular localization cell cycle regulation 18983824; 21907702 5 22 5 -CLEC4D CLEC4D Membrane protein, integral Q8WXI8 338339 12p13.31 human K9-ub 56836806 GLEKPQSkLEGGMHP protein degradation 27432944 1 0 0 negative regulation of antifungal immune response -Stx7 STX7 Membrane protein, integral; Vesicle O70439 53331 10|10 A4 mouse S126-p 468881 VARVRASsRVSGGFP molecular association, regulation STX8(INDUCES); VTI1B(INDUCES); VAMP8(INDUCES) 18710945 1 17 158 -SIK1 SIK EC 2.7.11.1; KINASE; Kinase, protein; Motility/polarity/chemotaxis; Protein kinase, CAMK; Protein kinase, Ser/Thr (non-receptor); Tumor suppressor P57059 150094 21q22.3 human S575-p 465992 FQEGRRAsDTSLTQG intracellular localization 22462548 10 21 4 -BRAF BRAF EC 2.7.11.1; KINASE; Kinase, protein; Oncoprotein; Protein kinase, Ser/Thr (non-receptor); Protein kinase, TKL P15056 673 7q34 human S579-p 456814 IIHRDLKsNNIFLHE PK_Tyr_Ser-Thr enzymatic activity, induced 16093354 1 0 0 mutation of T481 is less profound of an effect. B-Raf S579 shows similar effects to Raf1 S471.; Mutation of Raf1 S471 abolishes kinase activity and EGF-induced activity -Mapk3 ERK1 EC 2.7.11.24; KINASE; Kinase, protein; Protein kinase, CMGC; Protein kinase, Ser/Thr (non-receptor) Q63844 26417 7 F3|7 69.25 cM mouse Y205-p 447543 HTGFLTEyVATRWYR Pkinase intracellular localization; enzymatic activity, induced cell cycle regulation; carcinogenesis, induced; carcinogenesis, inhibited; apoptosis, induced; cell motility, induced; cell growth, inhibited; cell motility, inhibited; transcription, induced; signaling pathway regulation; transcription, altered; neural plasticity; cell growth, induced; apoptosis, inhibited; cytoskeletal reorganization; transcription, inhibited 10867029; 11934884; 12446705; 15788406; 15975986; 16103085; 19004831; 21562256; 21706057; 21813649; 21887248; 21917714; 25584415; 34118691; 34191798; 34520454; 34617326; 35085550; 35857631; 36070687; 36088505; 36310322; 36736425; 37160873; 37430253 1366 142 3549 -EIF2AK2 PKR EC 2.7.10.2; EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, Other; Protein kinase, Ser/Thr (non-receptor); Protein kinase, tyrosine (non-receptor); Translation P19525 5610 2p22.2 human T446-p 448088 LKNDGKRtRSKGTLR Pkinase protein conformation; phosphorylation; enzymatic activity, induced cell cycle regulation; apoptosis, induced; translation, induced; cell growth, altered 11432733; 15880455; 16179258; 35354045; 35947956; 9528799 17 1 0 -Gpr35 GPR35 GPCR, family 1; Membrane protein, integral; Membrane protein, multi-pass; Receptor, GPCR Q9ES90 64095 1|1 D mouse S298-p 1876282808 SSNTPHKsQDSQILS molecular association, regulation; intracellular localization ARR3(INDUCES) 35101446 1 1 0 -Ptpn12 PTP-PEST EC 3.1.3.48; Motility/polarity/chemotaxis; PHOSPHATASE; Protein phosphatase, tyrosine (non-receptor) P35831 19248 5|5 A3 mouse S434-p 451312 KKLERNLsFEIKKVP molecular association, regulation SKAP2(INDUCES) 23897807 3 57 41 -KAT5 Tip60 ACETYLTRANSFERASE; Acetyltransferase; EC 2.3.1.48; Nuclear receptor co-regulator; Nucleolus Q92993 10524 11q13.1 human K148-ac 52498003 QPNHRSTkRKVEVVS protein degradation; intracellular localization apoptosis, altered 25301942 1 0 0 HDAC3 increased the TIP60 half-life, and the ubiquitination level of TIP60, nuclear localization, cytoplasm and nucleus with HDAC3 expressed, TIP60 deacetylation increases its resistance to apoptosis -Il17rb IL17RB Membrane protein, integral Q9JIP3 50905 14 B|14 18.39 cM mouse Y454-p 40427500 GADLKGDyNALSVCP SEFIR molecular association, regulation STAT5A(INDUCES) 25821217 1 0 0 -SSU72 SSU72 EC 3.1.3.16; PHOSPHATASE; Phosphatase Q9NP77 29101 1p36.33 human S19-p 29614601 CSSNQNRsMEAHNIL Ssu72 protein degradation; ubiquitination; enzymatic activity, inhibited; protein conformation cell cycle regulation; chromatin organization, altered 24149858 1 0 0 Regulation of sister chromatid arm cohesion during early mitosis -MAP4 MAP4 Cytoskeletal; Motility/polarity/chemotaxis P27816 4134 3p21.31 human K702-ac 62495526 PSPEKKTkPLATTQP cytoskeletal reorganization 28002468 1 1 0 -SESN2 SESN2 P58004 83667 1p35.3 human S73-p 1869992401 GLEALMSsGRVDNLA PA26 molecular association, regulation; intracellular localization autophagy, induced ATP5A1(INDUCES) 32854424 1 1 0 -CSNK1A1 CK1A EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, CK1; Protein kinase, Ser/Thr (non-receptor) P48729 1452 5q32 human K225-ub 15386532 SLPWQGLkAATKKQK Pkinase protein degradation 26909574 1 5 1 -TDP1 TDP1 DNA repair, damage; EC 3.1.4.-; Phosphodiesterase Q9NUW8 55775 14q32.11 human S563-p 460794 KQKFFAGsQEPMATF Tyr-DNA_phospho molecular association, regulation LIG3(INDUCES) 34181949 2 2 7 -H2AFZ H2AZ DNA-binding Q5ZMD6 426361 chicken K11-ac 465514 KAGKDSGkTKTKAVS Histone chromatin organization, altered 19385636 4 13 417 K4, K7, and K11 acetylation destabilizes the nucleosome core particle (NCP) -OPRK1 KOR-1 GPCR, family 1; Membrane protein, integral; Membrane protein, multi-pass; Receptor, GPCR P41145 4986 8q11.23 human K338-ub 1975302 AFLDENFkRCFRDFC receptor internalization, induced; protein degradation 18212250 1 0 0 ubiquitination regulates but is not required for receptor downregulation -ARRDC4 ARRDC4 Unknown function Q8NCT1 91947 15q26.2 human K270-ub 1883454300 STDTWNGkTLKIPPV Arrestin_C activity, induced; protein stabilization; intracellular localization 35106941 1 1 0 trafficking of EV's -CDK10 CDK10 Cell cycle regulation; EC 2.7.11.22; KINASE; Kinase, protein; Protein kinase, CMGC; Protein kinase, Ser/Thr (non-receptor) Q15131 8558 16q24.3 human T133-p 27422500 SLLENMPtPFSEAQV Pkinase molecular association, regulation PIN1(INDUCES) 22158035 1 0 0 -MAP2K1 MEK1 EC 2.7.12.2; KINASE; Kinase, protein; Protein kinase, STE; Protein kinase, dual-specificity (non-receptor) Q02750 5604 15q22.31 human K362-ac 35480412 LMVHAFIkRSDAEEV enzymatic activity, induced cell growth, induced; transcription, induced 24681949 2 0 0 -WWTR1 TAZ Oncoprotein; Transcription, coactivator/corepressor Q9GZV5 25937 3q25.1 human S89-p 457660 AQHVRSHsSPASLQL protein degradation; molecular association, regulation; intracellular localization; activity, inhibited carcinogenesis, inhibited; cell growth, inhibited; transcription, induced; cell motility, inhibited; transcription, inhibited; transcription, altered 14-3-3 beta(INDUCES); NEK8(DISRUPTS) 20412773; 22078877; 23026745; 26375055; 33086783; 33545120; 34465890; 34859820; 36077517; 37337213 31 20 79 -Nr2c1 NR2C1 DNA-binding; Nuclear receptor Q505F1 22025 10 C2|10 48.81 cM mouse S568-p 456552 IGNVRIDsVIPHILK protein stabilization transcription, altered 16130175 1 0 0 -YAP1 YAP1 iso2 Oncoprotein; Transcription, coactivator/corepressor P46937-2 10413 11q22.1 human T396-p 23939103 SSYSVPRtPDDFLNS apoptosis, inhibited; transcription, induced 22308035 3 5 2 YAP phosphorylation is required for anti-apoptotic activity of YAP in cells which are deficient in p73 alpha/beta expression. -CNKSR1 CNK1 Adaptor/scaffold; G protein regulator, misc. Q969H4 10256 1p36.11 human Y519-p 50402001 PPREEDCySETEAED intracellular localization transcription, inhibited 26319181 1 1 0 -Bnip3 BNIP3 Membrane protein, integral; Mitochondrial Q9ET45 84480 1q41 rat T66-p 4698307 DSPPRSQtPQDTNRA BNIP3 protein stabilization; molecular association, regulation; ubiquitination autophagy, induced LC3B(INDUCES); ubiquitin(DISRUPTS) 36396625 1 12 0 inhibits ubiquitination, induces mitophagy -RB1 Rb Nuclear receptor co-regulator; Oncoprotein; Transcription, coactivator/corepressor; Tumor suppressor P06400 5925 13q14.2 human S612-p 447977 MYLSPVRsPKKKGST molecular association, regulation; protein conformation cell differentiation, induced; apoptosis, induced; transcription, altered E2F1(DISRUPTS); E2F1(INDUCES) 17380128; 20223825; 24466208; 9315635 13 18 33 -Coro1a coronin 1A Cytoskeletal; Motility/polarity/chemotaxis O89053 12721 7 69.25 cM|7 F3 mouse T418-p 4701031 DSARRRAtPEPSGTP Trimer_CC cell motility, altered; cytoskeletal reorganization 20937706 1 19 3 -NFE2L2 NRF2 DNA-binding; Transcription factor Q16236 4780 2q31.2 human K555-ac 7106313 KSLHLLKkQLSTLYL bZIP_Maf molecular association, regulation transcription, induced DNA(INDUCES) 19273602 1 1 0 -Irak1 IRAK1 EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, Ser/Thr (non-receptor); Protein kinase, TKL Q62406 16179 X A7.3|X 37.61 cM mouse T66-p 447722 CERSEQRtASVLWPW Death molecular association, regulation; enzymatic activity, induced transcription, altered PKCI(INDUCES) 14684752 3 0 0 autophosphorylation activity -Trhr TRHR GPCR, family 1; Membrane protein, integral; Membrane protein, multi-pass; Receptor, GPCR Q01717 25570 7q31 rat S355-p 1229702 YSVALNYsVIKESDR receptor internalization, altered 17989235; 20345371 3 0 0 -BUB1 BUB1 Cell cycle regulation; EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, Other; Protein kinase, Ser/Thr (non-receptor) O43683 699 2q13 human S314-p 481705 SHEDLPAsQERSEVN enzymatic activity, induced cell cycle regulation; DNA repair, induced 22071147; 22099307 4 5 0 required for the spindle checkpoint activation -PSME3 PSME3 Nuclear receptor co-regulator; Protease; Proteasome complex P61289 10197 17q21.31 human K14-sm 25344502 VDQEVKLkVDSFRER PA28_alpha protein stabilization; intracellular localization; enzymatic activity, induced 21445096 1 0 0 -ELF3 ELF3 DNA-binding; Motility/polarity/chemotaxis; Transcription factor P78545 1999 1q32.1 human S68-p 54363505 GEQPQFWsKTQVLDW SAM_PNT intracellular localization cell growth, induced; transcription, induced 26977885 1 1 0 nuclear localization, NOTCH3 expression -Slc22a1 SLC22A1 Membrane protein, integral; Membrane protein, multi-pass; Transporter; Transporter, SLC family Q63089 24904 1q11 rat S292-p 455611 ESPRWLLsQKRTTRA Sugar_tr activity, induced 15829703 1 0 0 stimulates ASP+ uptake -Tp53 p53 Activator; DNA-binding; Motility/polarity/chemotaxis; Nuclear receptor co-regulator; Transcription factor; Tumor suppressor P02340 22059 11 B3|11 42.83 cM mouse K162-ac 59149205 RAMAIYKkSQHMTEV P53 cell cycle regulation; carcinogenesis, inhibited; apoptosis, induced 33303641 2 0 0 senescence, ferroptosis, failed to develop early-onset tumors -Bmpr1a BMPR1A EC 2.7.11.30; KINASE; Kinase, protein; Membrane protein, integral; Protein kinase, Ser/Thr (receptor); Protein kinase, TKL P36895 12166 14 B|14 20.81 cM mouse Y457-p 25655000 VEEYQLPyYNMVPSD PK_Tyr_Ser-Thr molecular association, regulation cell growth, induced; signaling pathway regulation BMPR2(INDUCES); TAB1(DISRUPTS) 22729085 1 1 0 regulation of BMP downstream pathways-Erk1/2 and Smad1 activation, regulates life span of osteoblasts (expansion) -FSCN1 fascin Actin-binding; Cytoskeletal; Motility/polarity/chemotaxis Q16658 6624 7p22.1 human K42-ub 8106235 ASASSLKkKQIWTLE Fascin cytoskeletal reorganization 27879315 1 1 1 fascin bundling activity -WASF3 WASF3 Actin-binding; Motility/polarity/chemotaxis Q9UPY6 10810 13q12.13 human Y486-p 486451 SRRIAVEySDSDDDS cell motility, induced; cytoskeletal reorganization 17623672 1 0 0 induces lamellipodia formation -TRPV4 TRPV4 Channel, cation; Membrane protein, integral; Membrane protein, multi-pass Q9HBA0 59341 12q24.11 human T813-p 1868023603 QYYGFSHtVGRLRRD activity, induced 32186440 1 0 0 -UHRF1 UHRF1 DNA-binding; EC 6.3.2.-; EC 6.3.2.19; Ligase; Transcription factor; UBIQUITIN LIGASE; Ubiquitin conjugating system; Ubiquitin ligase Q96T88 29128 19p13.3 human K648-ac 1883407602 RTGKGKWkRKSAGGG cell cycle regulation; cell growth, induced 35951156 1 0 0 -Adam17 TACE EC 3.4.24.86; Membrane protein, integral; Motility/polarity/chemotaxis; Protease Q9Z0F8 11491 12 A1.3|12 8.3 cM mouse S794-p 449040 NSSTAAKsFEDLTDH molecular association, regulation; enzymatic activity, induced PLK2(INDUCES) 24338472 4 54 0 facilitates the sheddase activity of TACE -MFF MFF Membrane protein, integral; Mitochondrial Q9GZY8 56947 2q36.3 human K151-ub 1877722300 IRAVGRLkRERSMSE Miff protein degradation 31112535 1 0 0 PARK2 mediated lysosomal degradation of MFF -Il1rl1 IL1RL1 Membrane protein, integral; Receptor, cytokine P14719 17082 1 B|1 19.19 cM mouse S442-p 25585004 AATVVESsIQNSRRQ TIR receptor internalization, induced; protein degradation; molecular association, regulation FBXL19(INDUCES) 22660580; 25472995 2 0 0 -CDC34 CDC34 EC 6.3.2.19; Ligase; UBIQUITIN LIGASE; Ubiquitin conjugating system; Ubiquitin ligase P49427 997 19p13.3 human S236-p 448690 DDSGTEEs_______ intracellular localization 11546811 2 0 0 -PKLR PKLR iso2 Carbohydrate Metabolism - glycolysis and gluconeogenesis; Carbohydrate Metabolism - pyruvate; EC 2.7.1.40; Kinase, other; Nucleotide Metabolism - purine P30613-2 5313 1q22 human S12-p 1218250 AGYLRRAsVAQLTQE molecular association, regulation; protein conformation Other(DISRUPTS) 22052499; 23270483 5 1 6 disrupts binding with phospho enol pyruvate; energetic coupling of S12 phosphorylation and oxidation of Cys 436 to phosphoethanolamine binding -NFKBIA IkB-alpha DNA-binding; Inhibitor P25963 4792 14q13.2 human S32-p 448203 LLDDRHDsGLDSMKD protein degradation; protein stabilization; molecular association, regulation; phosphorylation; activity, induced; sumoylation; ubiquitination; intracellular localization apoptosis, altered; cell growth, induced; apoptosis, induced; apoptosis, inhibited; transcription, induced; signaling pathway regulation; transcription, altered IkB-beta(INDUCES); AurC(INDUCES) 10096573; 10723127; 10754328; 10882136; 11350057; 11502888; 11724787; 11752211; 11753679; 12068083; 12085227; 12138192; 12419817; 12432072; 12527907; 14523047; 15470067; 15843586; 16007147; 16163708; 16735506; 20385620; 20696840; 28467781; 29050234; 32416562; 33572115; 33876201; 33941613; 34558646; 34965427; 36292785; 36528060; 7739562; 7796813; 7878466; 8649784; 8657102; 9252186; 9351830; 9724653; 9734360 161 3 17 -Elk1 ELK1 DNA-binding; Transcription factor A4GTP4 314436 Xq11 rat K248-sm 3982500 RPQPPEVkVEGPKEE apoptosis, inhibited; transcription, inhibited 30849179 6 1 0 GADD45A expression; APP/PS1 rats -Yy1 YY1 C2H2-type zinc finger protein; Cell development/differentiation; Transcription factor Q00899 22632 12 F1|12 59.58 cM mouse S365-p 15416769 EGCGKRFsLDFNLRT zf-C2H2 molecular association, regulation; phosphorylation transcription, induced; signaling pathway regulation CBX4(DISRUPTS) 22482732 2 5 3 -Myo3b MYO3B Actin-binding; EC 2.7.11.1; KINASE; Kinase, protein; Motor; Protein kinase, STE; Protein kinase, Ser/Thr (non-receptor) Q1EG27 329421 2|2 C2 mouse S887-p 36841907 KITASSRsLPPHFSA Myosin_head enzymatic activity, induced 21895655 1 1 0 -RBBP8 CtIP EC 3.1.-.-; Transcription, coactivator/corepressor Q99708 5932 18q11.2 human S231-p 33625700 VADTYDQsQSPMAKA enzymatic activity, induced 24837676 1 1 0 -NR4A2 NR4A2 DNA-binding; Nuclear receptor P43354 4929 2q24.1 human S126-p 487424 SVYYKPSsPPTPTTP intracellular localization transcription, induced 17681692; 24223135 3 0 0 -CLIP1 Restin Cytoskeletal P30622 6249 12q24.31 human S195-p 468616 LTKTASEsISNLSEA intracellular localization; phosphorylation 20664522 2 56 33 enhances phosphorylation of S1353 -SPAG5 SPAG5 Cell cycle regulation Q96R06 10615 17q11.2 human S249-p 460404 PSSVLWLsPSTALAA intracellular localization cell cycle regulation 27325694 1 10 0 localization and formation of kinetochores -Pak1 PAK1 EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, STE; Protein kinase, Ser/Thr (non-receptor) P35465 29431 1q32 rat T422-p 448177 PEQSKRStMVGTPYW Pkinase molecular association, regulation; enzymatic activity, induced cytoskeletal reorganization N-WASP(INDUCES) 11278486; 28972183 39 4 11 -Nfkbia IkB-alpha DNA-binding; Inhibitor Q9Z1E3 18035 12|12 C1 mouse S293-p 451525 EESYDTEsEFTEDEL protein degradation 8668171 3 0 0 S293 phosphorylation is required for rapid proteolysis of the unassociated protein. -SMAD4 SMAD4 DNA-binding; Nuclear receptor co-regulator; Transcription, coactivator/corepressor Q13485 4089 18q21.2 human T265-p 36694101 ATYHHNStTTWTGSR protein degradation; molecular association, regulation; ubiquitination carcinogenesis, inhibited; transcription, inhibited; signaling pathway regulation BTRC(INDUCES) 25373906 1 0 0 -FOXO3 FOXO3A Autophagy; DNA-binding; Oncoprotein; Transcription factor O43524 2309 6q21 human S644-p 451438 GLDFNFDsLISTQNV FOXO-TAD protein degradation; intracellular localization; activity, inhibited cell cycle regulation; apoptosis, inhibited; transcription, inhibited 15084260; 23691078 3 0 0 nuclear to cytoplasm transport, repressed FOXO3A-induced p27 promoter activity -NUPR1 NUPR1 Apoptosis; Cell cycle regulation; Cell development/differentiation O60356 26471 16p11.2 human T68-p 1870426000 GHERKLVtKLQNSER Phospho_p8 molecular association, regulation; protein conformation KPNA4(DISRUPTS) 32933064 1 0 0 -SIAH1 SIAH1 Apoptosis; Cell development/differentiation; EC 6.3.2.-; EC 6.3.2.19; Ligase; Motility/polarity/chemotaxis; UBIQUITIN LIGASE; Ubiquitin conjugating system; Ubiquitin ligase Q8IUQ4 6477 16q12.1 human T235-p 36694106 NGHRRRLtWEATPRS Sina molecular association, regulation; acetylation; intracellular localization signaling pathway regulation GAPDH(INDUCES) 25391652 1 0 0 augments p300 acetylation; nuclear translocation -HSPA5 GRP78 Chaperone; Heat shock protein; KINASE P11021 3309 9q33.3 human K376-ac 466066 PKIQQLVkEFFNGKE HSP70 molecular association, regulation; phosphorylation apoptosis, induced; signaling pathway regulation PERK(DISRUPTS) 20371724 1 3 5 induces phosphorylation of elf2a and activation of eIf2a-ATF4-CHOP pathway -Usf1 USF1 DNA-binding; Transcription factor Q61069 22278 1 H3|1 79.4 cM mouse S262-p 7367003 RQSNHRLsEELQGLD molecular association, regulation; acetylation transcription, altered SREBP-1(INDUCES) 19303849 2 1 0 -Prdx6 PRDX6 Amino Acid Metabolism - phenylalanine; EC 1.11.1.15; EC 1.11.1.9; Energy Metabolism - methane; Oxidoreductase; Phospholipase O08709 11758 1 H2.1|1 69.75 cM mouse T177-p 3823356 TGTKPVAtPVDWKKG 1-cysPrx_C activity, induced; intracellular localization 21262967 4 5 12 NOX2 activated -PRKDC DNAPK DNA repair, damage; EC 2.7.11.1; KINASE; Kinase, protein; Nucleolus; Protein kinase, Ser/Thr (non-receptor); Protein kinase, atypical P78527 5591 8q11.21 human T2638-p 448712 VAGQIRAtQQQHDFT DNAPKcs_CC5 molecular association, regulation; protein conformation DNA repair, induced; chromatin organization, altered; cell growth, altered DNA(DISRUPTS) 17189255; 24687855 6 13 8 increases survival in ionizing radiation and repairing double strand DNA breaks; cell survival induced, induces removal of cisplatin adducts from DNA, induces end processing -KCNA3 Kv1.3 Channel, potassium; Membrane protein, integral; Membrane protein, multi-pass P22001 3738 1p13.3 human Y187-p 451293 FSEEIRFyQLGEEAM BTB_2 activity, induced 11812778 1 0 0 -MASTL MASTL EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, AGC; Protein kinase, Ser/Thr (non-receptor) Q96GX5 84930 10p12.1 human T194-p 3209097 NMMDILTtPSMAKPR Pkinase activity, induced; intracellular localization cell cycle regulation 24391510 2 3 0 -TRAPPC6A TRAPPC6A O75865 79090 19q13.32 human S35-p 23155168 GGQKMSLsVLEGMGF TRAPP molecular association, regulation; intracellular localization; protein conformation apoptosis, induced TIAF1(INDUCES) 25650666; 27551439 2 0 1 Mutant proteins do not cause aggregation or caspase activation. ; protein aggregation, Ser35 phosphorylation is essential for relocation of TPC6A to the nucleolus and pTyr112 needed for relocation to the cytoplasm -DLG4 PSD-95 Adaptor/scaffold P78352 1742 17p13.1 human Y523-p 4093600 REDSVLSyETVTQME activity, induced; molecular association, regulation; phosphorylation neural plasticity; apoptosis, induced Pyk2(INDUCES) 22709448; 24981431 3 0 0 activation of NMDA receptor function, NR2A phosphorylation; neural excitotoxicity increased -Zbp1 ZBP1 DNA-binding; Motility/polarity/chemotaxis Q9QY24 58203 2|2 H3 mouse K17-ub 1873076610 TGDNLEQkILQVLSD z-alpha apoptosis, induced 28634194 1 1 0 induces apoptosis due to influenza A virus infection -PIAS1 PIAS1 EC 6.3.2.-; Nuclear receptor co-regulator; SUMO LIGASE; SUMO conjugating system; SUMO ligase; Transcription, coactivator/corepressor O75925 8554 15q23 human K238-sm 55435684 PGYLPPTkNGVEPKR PINIT intracellular localization 32047143 1 3 0 -SNX5 SNX5 Vesicle Q9Y5X3 27131 20p11.23 human S226-p 1296362401 YYNRIKDsCVKADKM Vps5 molecular association, regulation; intracellular localization; activity, inhibited endocytosis, induced SNX1(DISRUPTS); SNX2(DISRUPTS) 30419003 1 1 0 Phosphorylation of SNX5 inhibits both macropinocytosis and CI-M6PR retrograde transport. -PRMT8 PRMT8 EC 2.1.1.-; METHYLTRANSFERASE; Methyltransferase; Methyltransferase, protein arginine Q9NR22 56341 12p13.32 human R58-m1 2574937 TQPSCPGrGKMSKLL enzymatic activity, altered PRMT8(INDUCES) 17925405 1 1 0 automethylation -TPT1 TPT1 Calcium-binding; Microtubule-binding P13693 7178 13q14.13 human T65-p 34501092 EGEGTEStVITGVDI TCTP protein degradation carcinogenesis, inhibited; apoptosis, induced 34675258 1 2 0 -PECAM1 PECAM-1 Cell adhesion; Cell development/differentiation; Membrane protein, integral; Motility/polarity/chemotaxis P16284 5175 17q23.3 human S700-p 455609 VQVSSAEsHKDLGKK molecular association, regulation CTNNG(DISRUPTS) 15766557 1 1 2 -Braf BRAF iso1 EC 2.7.11.1; KINASE; Kinase, protein; Oncoprotein; Protein kinase, Ser/Thr (non-receptor); Protein kinase, TKL P28028-1 109880 6 B1|6 18.43 cM mouse S639-p 447805 FGLATVKsRWSGSHQ PK_Tyr_Ser-Thr activity, induced; phosphorylation carcinogenesis, induced; signaling pathway regulation 30659267 11 0 0 phosphorylation of MEK/ERK and its signaling -GLO1 GLO1 Carbohydrate Metabolism - pyruvate; EC 4.4.1.5; Lyase Q04760 2739 6p21.2 human Y136-p 463450 GIAVPDVySACKRFE Glyoxalase enzymatic activity, induced 34838714 1 0 19 -Slc14a2 SLC14A2 Membrane protein, integral; Membrane protein, multi-pass; Transporter; Transporter, SLC family Q62668 54302 18q12.3 rat T524-p 2813502 PYLYRKPtVELLDLN activity, induced 18495802 1 0 0 -CCAR2 DBC-1 Apoptosis; Mitochondrial; Nuclear receptor co-regulator; RNA-binding; Tumor suppressor Q8N163 57805 8p21.3 human T454-p 453498 AAEAAPPtQEAQGET DBC1 molecular association, regulation; activity, inhibited SIRT1(INDUCES) 25361978 3 7 38 inhibits SIRT1 -SLC9A1 NHE1 Membrane protein, integral; Membrane protein, multi-pass; Motility/polarity/chemotaxis; Transporter; Transporter, SLC family P19634 6548 1p36.11 human S693-p 468293 VPAHKLDsPTMSRAR NEXCaM_BD protein stabilization; protein conformation 28554535 2 56 161 -Jph2 JPH2 Contractile; Endoplasmic reticulum; Membrane protein, integral Q9ET78 59091 2|2 H2-H3 mouse S165-p 4779179 PLRTSLSsLRSEHSN molecular association, regulation TRPC3(INDUCES) 20095964 2 5 1 S165F mutant showes hypertrophy and increased resting cytoplasmic Ca2+ levels. -Hist1h2ail1 H3 DNA-binding Q6LED0 291159 17p11 rat S10-p 455676 TKQTARKsTGGKAPR Histone chromatin organization, altered; cytoskeletal reorganization; transcription, induced 17880897; 19940164 241 15 1 correlated with nuclear infolding -CLSPN claspin Actin-binding; Cell cycle regulation Q9HAW4 63967 1p34.3 human S34-p 467251 PSDSGQGsYETIGPL protein degradation; molecular association, regulation cell cycle regulation BTRC(INDUCES) 16885022 1 0 0 claspin degradation is necessary for termination of the DNA replication checkpoint. -FLCN FLCN Tumor suppressor Q8NFG4 201163 17p11.2 human S406-p 35542208 CVRIIPYsSQYEEAY Folliculin_C molecular association, regulation FNIP2(INDUCES); LC3B(DISRUPTS); GABARAP(DISRUPTS) 25126726 1 1 0 -Bcl2l1 Bcl-xL Apoptosis; Autophagy; Membrane protein, integral; Mitochondrial P53563 24888 3q41 rat S106-p 5014911 LRYRRAFsDLTSQLH Bcl-2 molecular association, regulation apoptosis, altered VDAC1(DISRUPTS); Akt1(INDUCES) 18951975 1 0 0 -Oprd1 DOR-1 GPCR, family 1; Membrane protein, integral; Membrane protein, multi-pass; Receptor, GPCR P32300 18386 4 D2.3|4 64.78 cM mouse S344-p 448552 CGRQEPGsLRRPRQA receptor desensitization, altered; receptor internalization, altered 11085981 1 0 0 -DLGAP1 SAPAP1 Cytoskeletal O14490 9229 18p11.31 human S375-p 481510 KVAARREsYLKATQP molecular association, regulation PSD-95(INDUCES) 22117215 2 1 0 Fluorescence Polarization -Sox9 SOX9 DNA-binding; Transcription factor Q04887 20682 11 E2|11 77.27 cM mouse R152-me 10338210 LLNESEKrPFVEEAE HMG_box molecular association, regulation cell cycle regulation; cell growth, induced; transcription, induced CTNNB1(DISRUPTS) 19725955 1 0 0 promotes cyclin D1 expression, regulates endochondral ossification, chondrocyte/cartilage development during embryogenesis -Cish CISH O70512 83681 8q32 rat K97-ub 37044800 EARQHLQkMPEGTFL SH2 protein degradation 25448846 1 0 0 -POLDIP3 SKAR RNA-binding Q9BY77 84271 22q13.2 human S385-p 454011 PRRVNSAsSSNPPAE activity, induced ERH(NOT_REPORTED) 15341740; 16984396 2 2 1 phosphorylation of this site is involved in the control of cell growth -Bcl2l11 BIM Apoptosis O54918 12125 2|2 F1 mouse S65-p 449330 GPLAPPAsPGPFATR protein degradation; molecular association, regulation apoptosis, altered; apoptosis, induced; apoptosis, inhibited BAX(DISRUPTS) 12818176; 15486085; 17105963; 18498746 23 1 1 -PRPF19 PRPF19 EC 6.3.2.-; EC 6.3.2.19; Ligase; RNA splicing; Spliceosome; UBIQUITIN LIGASE; Ubiquitin conjugating system; Ubiquitin ligase Q9UMS4 27339 11q12.2 human Y405-p 31823502 IAFSENGyYLATAAD WD40 molecular association, regulation; intracellular localization RFA2(INDUCES); H2AX(INDUCES) 24332808 1 0 0 -PIK3R1 PIK3R1 KINASE; Kinase, lipid; Motility/polarity/chemotaxis P27986 5295 5q13.1 human S608-p 448133 ENTEDQYsLVEDDED activity, induced 14729945 3 3 24 -IGF1R IGF1R EC 2.7.10.1; KINASE; Kinase, protein; Membrane protein, integral; Protein kinase, TK; Protein kinase, tyrosine (receptor) P08069 3480 15q26.3 human S1311-p 2091902 PLDPSASsSSLPLPD activity, induced; phosphorylation cell differentiation, altered; apoptosis, altered; cell growth, altered 10746631; 10786694 2 0 0 observed in Y980F + S1310-1313A; ERK phosphorylation -PARP1 PARP1 DNA repair, damage; EC 2.4.2.30; Nuclear envelope; Nuclear receptor co-regulator; Nucleolus; Transferase P09874 142 1q42.12 human K249-ac 12234031 NDLIWNIkDELKKVC protein degradation; ubiquitination 34555594; 35066290 2 1 3 -TOP1 TOP1 EC 5.99.1.2; Isomerase; Nucleolus; Oncoprotein P11387 7150 20q12 human S10-p 465604 GDHLHNDsQIEADFR protein degradation 28415827 3 31 0 -ACBD4 ACBD4 Lipid-binding Q8NC06 79777 17q21.31 human S169-p 34498308 PAPPSPEsHSPRDLD molecular association, regulation VAPB(INDUCES) 35019937 1 1 0 -Ror2 ROR2 EC 2.7.10.1; KINASE; Kinase, protein; Membrane protein, integral; Protein kinase, TK; Protein kinase, tyrosine (receptor) Q9Z138 26564 13 B1|13 27.68 cM mouse S864-p 20659200 PKPSSHHsGSGSTST cell motility, induced 21078818 1 0 0 -Dnm1l DRP1 Apoptosis; EC 3.6.5.5; Endoplasmic reticulum; Hydrolase; Microtubule-binding; Mitochondrial; Motor Q8K1M6 74006 16|16 A2 mouse S643-p 483971 VPVARKLsAREQRDC intracellular localization; activity, inhibited; phosphorylation transcription, induced; transcription, altered; signaling pathway regulation; autophagy, induced; cell growth, induced; apoptosis, inhibited; autophagy, inhibited; transcription, inhibited 28591721; 31326607; 33485986; 34433037; 34705256; 34940790; 35720196; 35791786; 35819738; 35860026; 36008706 103 3 0 -ZBTB1 ZBTB1 C2H2-type zinc finger protein Q9Y2K1 22890 14q23.3 human K265-sm 2894413 DGKDSNIkAEFGEKD activity, inhibited transcription, altered 20797634 1 3 0 reduces transcriptional repressive activity -Lrrc7 LRRC7 Cell adhesion P70587 117284 2q45 rat S1392-p 481330 IQTKGQRsMDGYPEQ molecular association, regulation CAMK2A(DISRUPTS) 11160423 1 10 0 -Lrp6 LRP6 Membrane protein, integral; Receptor, misc. O88572 16974 6 G1|6 65.37 cM mouse S1490-p 456289 AILNPPPsPATERSH intracellular localization cell differentiation, inhibited; carcinogenesis, induced; cell growth, induced; transcription, induced; signaling pathway regulation 24692544; 32139604; 33929542; 36103813 32 13 55 -RPTOR Raptor Adaptor/scaffold Q8N122 57521 17q25.3 human S859-p 2024885 DTSSLTQsAPASPTN molecular association, regulation signaling pathway regulation mTOR(INDUCES); 4E-BP1(DISRUPTS) 21460630; 26348909 5 70 5 mTORC1 signaling -Max MAX DNA-binding; Transcription factor P52164 60661 6q24 rat S2-p 449307 ______MsDNDDIEV molecular association, regulation DNA(NOT_REPORTED) 8247525 5 35 0 increases both the on- and off-rates for DNA binding -Pag1 PAG Adaptor/scaffold; Membrane protein, integral Q3U1F9 94212 3|3 A1 mouse Y314-p 450659 EEEISAMySSVNKPG PAG molecular association, regulation CSK(INDUCES) 17210649 9 31 643 -Carm1 CARM1 EC 2.1.1.125; METHYLTRANSFERASE; Methyltransferase; Methyltransferase, protein arginine; Nuclear receptor co-regulator Q9WVG6 59035 9|9 A3 mouse S217-p 11311202 KIYAVEAsTMAQHAE PrmA intracellular localization; enzymatic activity, inhibited 19843527 1 1 0 reduces cofactor AdoMet binding -KAT2A GCN5 ACETYLTRANSFERASE; Acetyltransferase; EC 2.3.1.48 Q92830 2648 17q21.2 human K549-ac 27421702 LVFDPKHkTLALIKD Acetyltransf_1 acetylation; enzymatic activity, induced transcription, altered 23142079 1 1 0 direct opposition to Sirt1; increases PGC-1a acetylation; Regulates the gluconeogenic transcriptional response of fasted mice -Axin1 axin 1 Adaptor/scaffold; Tumor suppressor O70239 79257 10q12 rat S485-p 451092 MRTPGCQsPGPGHRS Axin_b-cat_bind cytoskeletal reorganization 22933777 2 9 6 Phosphorylation regulates responsive to Sema3A induced growth cone collapse. -CUL5 CUL5 UBIQUITIN LIGASE; Ubiquitin conjugating system; Ubiquitin ligase Q93034 8065 11q22.3 human S730-p 963800 MKMRKKIsNAQLQTE Cullin_Nedd8 intracellular localization; activity, inhibited; neddylation; phosphorylation cell cycle regulation; cell growth, inhibited; cell growth, altered 10898738; 12917106; 19917606; 21635549 5 0 0 -FGFR1 FGFR1 EC 2.7.10.1; KINASE; Kinase, protein; Membrane protein, integral; Oncoprotein; Protein kinase, TK; Protein kinase, tyrosine (receptor) P11362 2260 8p11.23 human S779-p 27930809 PLDQYSPsFPDTRSS cell differentiation, induced; apoptosis, inhibited 23564461 1 0 0 neurite extension -SQSTM1 SQSTM1 Autophagy; Nuclear receptor co-regulator; Ubiquitin conjugating system Q13501 8878 5q35.3 human S403-p 22264800 ESLSQMLsMGFSDEG UBA_5 activity, induced; protein degradation; molecular association, regulation; ubiquitination; intracellular localization; phosphorylation autophagy, induced; cell growth, induced; cell differentiation, induced; transcription, induced; autophagy, inhibited; signaling pathway regulation ubiquitin(INDUCES); KEAP1(INDUCES) 22017874; 22921120; 25505069; 27846364; 29147513; 31444413; 32835772; 34226595; 34903812; 36284367; 37306101 30 7 0 -SLC4A1 SLC4A1 Membrane protein, integral; Membrane protein, multi-pass; Transporter; Transporter, SLC family P02730 6521 17q21.31 human Y904-p 455304 EEEGRDEyDEVAMPV intracellular localization 15649129 8 4 36 -Map2 MAP2 iso3 Cytoskeletal; Motility/polarity/chemotaxis P15146-3 25595 9q32 rat K292-ac 62495500 AIIRTPPkSPATPKQ cytoskeletal reorganization 28002468 1 1 0 -GRIN2A NMDAR2A Channel, ligand-gated; Membrane protein, integral; Membrane protein, multi-pass Q12879 2903 16p13.2 human Y1325-p 458211 RLLEGNFyGSLFSVP NMDAR2_C activity, induced 19834457 8 2 84 -Ezr Ezrin Cytoskeletal; Motility/polarity/chemotaxis P26040 22350 17|17 A1 mouse Y146-p 448758 KEMHKSGyLSSERLI FERM_M intracellular localization; phosphorylation cell cycle regulation; apoptosis, inhibited; cell growth, altered 18182570; 24385580 16 2 2 localization at the plasma membrane; ERK phosphorylation -Prkg2 PKG2 EC 2.7.11.12; KINASE; Kinase, protein; Protein kinase, AGC; Protein kinase, Ser/Thr (non-receptor) Q61410 19092 5 E3|5 48.35 cM mouse S126-p 450477 RGAKAGVsAEPTTRT enzymatic activity, induced transcription, induced; signaling pathway regulation 12764134; 21131365 2 1 0 induces NFAT signaling -DNAJB1 HSP40 Chaperone; Nucleolus P25685 3337 19p13.12 human S171-p 30306602 VTHDLRVsLEEIYSG DnaJ_C transcription, inhibited 24309468 1 2 0 -Lipe HSL EC 3.1.1.79; Lipase P15304 25330 1q21 rat S865-p 448804 ESMRRSVsEAALAQP enzymatic activity, induced 9636039 27 28 1 -SMN1 SMN RNA processing; RNA-binding Q16637 6606 5q13.2 human S88-p 5498504 QKKNTAAsLQQWKVG SMN molecular association, regulation; intracellular localization coilin(INDUCES) 24602413 1 2 2 -VAV3 VAV3 Actin-binding; Adaptor/scaffold; GEF; GEF, Rac/Rho; Motility/polarity/chemotaxis; Nuclear receptor co-regulator Q9UKW4 10451 1p13.3 human Y164-p 1869344402 EDLYDCVyGEDEGGE activity, induced 32561640 1 0 0 VAV3 signaling activity -Cebpb C/EBP-beta DNA-binding; Motility/polarity/chemotaxis; Transcription factor P28033 12608 2 H3|2 87.58 cM mouse K215-ac 458939 APAKAKAkKTVDKLS molecular association, regulation transcription, inhibited DNA(DISRUPTS) 22865229 4 0 0 -YY1 YY1 C2H2-type zinc finger protein; Cell development/differentiation; Transcription factor P25490 7528 14q32.2 human S118-p 460025 EVVGGDDsDGLRAED protein stabilization 22184066 3 34 0 prevention of phosphorylation at this site enhances YY1 cleavage by caspase 7 during apoptosis -ZXDC ZXDC C2H2-type zinc finger protein Q2QGD7 79364 3q21.3 human K660-sm 2890300 PELLAPIkVEPDSPS transcription, induced 17696781 1 1 0 -E2F3 E2F3 Cell cycle regulation; DNA-binding; Transcription factor O00716 1871 6p22.3 human S124-p 11929101 PALGRGGsGGGGGPP protein stabilization DNA repair, induced; transcription, induced 26921499 2 0 0 -Ar AR DNA-binding; Nuclear receptor; Transcription factor P19091 11835 X C3|X 42.82 cM mouse Y531-p 1243001 DHVLPIDyYFPPQKT intracellular localization cell cycle regulation; carcinogenesis, induced; cell motility, induced; cell growth, induced; transcription, induced 35595729 1 1 0 -Kcnc3 Kv3.3 Membrane protein, integral; Membrane protein, multi-pass Q63959 16504 7 B3|7 28.85 cM mouse S9-p 2840510 LSSVCVWsFRGRQGT Potassium_chann activity, inhibited 18539595 1 0 0 -Gabbr1 GABBR1 GPCR, family 3; Membrane protein, integral; Membrane protein, multi-pass; Receptor, GPCR Q9Z0U4 81657 20p12 rat K697-ub 59175201 VFTKKEEkKEWRKTL 7tm_3 receptor recycling, inhibited; protein degradation; intracellular localization 27573246 1 0 0 -NR3C2 MCR DNA-binding; Nuclear receptor P08235 4306 4q31.23 human T800-p 1875398904 LPLEDQItLIQYSWM Hormone_recep molecular association, regulation; intracellular localization transcription, induced DNA(INDUCES) 34847273 1 0 0 -Grap2 GADS Adaptor/scaffold O89100 17444 15|15 E1 mouse T254-p 451895 TLMHRRHtDPVQLQA molecular association, regulation 14-3-3 zeta(INDUCES) 22105350 2 16 142 phosphorylation causes a disruption of microclusters and prevents T cell activation -PDCD6IP Alix Adaptor/scaffold; Apoptosis Q8WUM4 10015 3p22.3 human Y319-p 457636 KKDNDFIyHDRVPDL BRO1 molecular association, regulation; protein conformation cell adhesion, altered Pyk2(INDUCES); Src iso1(INDUCES); Alix(DISRUPTS); FAK(INDUCES) 12771190; 15557335; 34688656 3 4 88 -PDE6G PDE6G EC 3.1.4.35; Nucleotide Metabolism - purine; Phosphodiesterase P04972 281977 cow T35-p 450149 PKFKQRQtRQFKSKP PDE6_gamma phosphorylation 19878658 5 0 0 phosphorylation of T22 is attenuated in PDE6G T35A mutant -CCR7 CCR7 GPCR, family 1; Membrane protein, integral; Membrane protein, multi-pass; Motility/polarity/chemotaxis; Receptor, GPCR P32248 1236 17q21.2 human Y155-p 53340200 LCISIDRyVAIVQAV 7tm_1 molecular association, regulation cell motility, induced; signaling pathway regulation SHP-2(INDUCES); RAC1(INDUCES); VAV1(INDUCES) 26789922; 31644919 2 0 0 T cell migration toward CCL21; phosphorylation induces interaction with VAV1, further enhancing Rac1 recruitment and regulating CCR7 signaling complex -BCL2L11 BIM iso2 Apoptosis O43521-2 10018 2q13 human T56-p 449071 SCDKSTQtPSPPCQA activity, induced; molecular association, regulation apoptosis, induced LC8(DISRUPTS) 12591950 10 1 0 -Stat6 STAT6 DNA-binding; Transcription factor P52633 20852 10 D3|10 74.59 cM mouse T645-p 451417 GRGYVSTtIKMTVER apoptosis, inhibited; cell motility, inhibited; transcription, inhibited 33934104 1 1 1 reduce TNF alpha production and tubular cell death -Esrrg ERR3 DNA-binding; Nuclear receptor; Transcription factor P62509 26381 1|1 H5-H6 mouse S179-p 36400701 ITKRRRKsCQACRFM zf-C4 intracellular localization transcription, inhibited 25205222 1 0 0 inhibits hepatic gluconeogenesis -ARHGAP5 ARHGAP5 GAP; GAP, Rac/Rho; Motility/polarity/chemotaxis Q13017 394 14q12 human Y306-p 449920 NHPDYEEyINLEGTR RhoGAP-FF1 intracellular localization cell differentiation, altered 12705864 1 0 0 -FANCD2 FANCD2 DNA repair, damage Q9BXW9 2177 3p25.3 human S891-p 1871613601 TLSEEKNsECDPTPS FancD2 molecular association, regulation; ubiquitination; intracellular localization; activity, inhibited cell cycle regulation; DNA repair, inhibited; signaling pathway regulation DNA(DISRUPTS) 31167143 1 1 0 inhibits Fanconi anemia pathway leading to inhibition of DNA repair; 882-898 cluster -IKBKG IKKG Adaptor/scaffold; Protein kinase, regulatory subunit Q9Y6K9 8517 Xq28 human K277-ub 486354 AEEALVAkQEVIDKL CC2-LZ activity, inhibited transcription, induced; transcription, inhibited 14651848; 19223549; 28490597 3 2 0 regulates activation of NF-kB -Itgb2 ITGB2 Cell adhesion; Cell surface; Membrane protein, integral; Motility/polarity/chemotaxis; Receptor, misc. P11835 16414 10 C1|10 39.72 cM mouse T761-p 448535 PLFKSATtTVMNPKF Integrin_b_cyt cell motility, induced; cell adhesion, induced 23823319 2 0 0 T-cell homing to lymphocytes -Nlrp3 NLRP3 Inhibitor Q8R4B8 216799 11|11 B1.3 mouse S725-p 31904665 VNCCLTSsFCRGLFS activity, induced; molecular association, regulation NLRP3(INDUCES) 34480147 3 4 0 -KLF10 KLF10 C2H2-type zinc finger protein; DNA-binding; Transcription factor Q13118 7071 8q22.3 human T93-p 23119614 TIPAFCLtPPYSPSD protein degradation; molecular association, regulation PIN1(INDUCES) 23994618 1 0 1 -TET2 TET2 EC 1.14.11.n2; Oxidoreductase; Tumor suppressor Q6N021 54790 4q24 human K111-ac 63106403 SGLLQIKkLKQDQKA protein stabilization; molecular association, regulation; ubiquitination; methylation; enzymatic activity, induced DNA repair, induced DNMT1(INDUCES) DNA(INDUCES) 28107650 1 1 0 inhibits ubiquitination, protects against abnormal DNA methylation -FOSL2 FRA2 DNA-binding; Transcription factor P15408 2355 2p23.2 human S320-p 4707550 QSSDSLNsPTLLAL_ methylation cell differentiation, induced; transcription, induced 25547114 2 14 11 -HTRA2 HTRA2 EC 3.4.21.108; Membrane protein, integral; Mitochondrial; Protease O43464 27429 2p13.1 human S212-p 477180 RVRVRLLsGDTYEAV Peptidase_M50; Trypsin_2 intracellular localization; enzymatic activity, inhibited apoptosis, induced 17311912 1 0 2 -NDEL1 NDEL1 Microtubule-binding; Protease Q9GZM8 81565 17p13.1 human T245-p 3211851 GFGTSPLtPSARISA NUDE_C molecular association, regulation; intracellular localization PAFAH1B1(INDUCES) 12556484 2 7 3 -AHSG FETUA Secreted; Secreted, signal peptide P02765 197 3q27.3 human S328-p 467424 MGVVSLGsPSGEVSH signaling pathway regulation 35522655 2 20 22 repair insulin signaling -Ctnnb1 CTNNB1 Actin-binding; Cell adhesion; Motility/polarity/chemotaxis; Nuclear receptor co-regulator; Oncoprotein; Transcription factor Q9WU82 84353 8q32 rat S552-p 472273 QDTQRRTsMGGTQQQ protein stabilization; intracellular localization cell cycle regulation; autophagy, induced; cell growth, induced 33518533 44 64 9 -Abi1 Abi-1 Adaptor/scaffold; Motility/polarity/chemotaxis Q8CBW3 11308 2 A3|2 15.18 cM mouse S88-p 27115701 SQLRRMEsSINHISQ cytoskeletal reorganization 22993434 1 1 0 Rac activation and spine maturation -ZC3HC1 NIPA Cell cycle regulation; Ubiquitin conjugating system Q86WB0 51530 7q32.2 human S338-p 468305 DATFSPGsEQAEKSP Rsm1 molecular association, regulation; intracellular localization cell growth, induced NPM-ALK(DISRUPTS) 31434245 1 29 2 -Map2 MAP2 iso3 Cytoskeletal; Motility/polarity/chemotaxis P15146-3 25595 9q32 rat K379-ac 62495507 FKEKAQAkVGSLDNA Tubulin-binding cytoskeletal reorganization 28002468 1 1 0 -INPP5D SHIP EC 3.1.3.86; Motility/polarity/chemotaxis; Phosphatase, lipid Q92835 3635 2q37.1 human S27-p 15621800 SRTGKDGsFLVRASE SH2 protein degradation carcinogenesis, induced; cell growth, induced 31377397 2 2 0 -Ctnnb1 CTNNB1 Actin-binding; Cell adhesion; Motility/polarity/chemotaxis; Nuclear receptor co-regulator; Oncoprotein; Transcription factor Q9WU82 84353 8q32 rat S37-p 447582 YLDSGIHsGATTTAP protein degradation 14985333 110 3 12 -PDPK1 PDK1 EC 2.7.11.1; KINASE; Kinase, protein; Nuclear receptor co-regulator; Protein kinase, AGC; Protein kinase, Ser/Thr (non-receptor) O15530 5170 16p13.3 human Y9-p 447696 ARTTSQLyDAVPIQS protein degradation; molecular association, regulation; phosphorylation; enzymatic activity, induced transcription, altered HSP90A(INDUCES); Src(INDUCES) 12738763; 18024423 5 1 6 phosphorylation of PDK1 Y373/376; inhibits p53 promoter transcription -PIN1 PIN1 EC 5.2.1.8; Isomerase; Nuclear receptor co-regulator Q13526 5300 19p13.2 human S65-p 456481 SHLLVKHsQSRRPSS Rotamase protein stabilization 16118204 1 1 0 -LIMK1 LIMK1 EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, Ser/Thr (non-receptor); Protein kinase, TKL P53667 3984 7q11.23 human S323-p 459630 KDLGRSEsLRVVCRP enzymatic activity, induced cell motility, altered 16456544 1 3 0 important for VEGF-induced stress fiber formation -Pdxk PDXK Cofactor and Vitamin Metabolism - vitamin B6; EC 2.7.1.35; Kinase, other O35331 83578 20p12 rat S285-p 3403601 AGEGQKPsPAQLELR Phos_pyr_kin enzymatic activity, induced 35050500 0 8 0 -MYH7 MYH7 Motility/polarity/chemotaxis; Motor P12883 4625 14q11.2 human K58-ac 36295041 IVSREGGkVTAETEY Myosin_N molecular association, regulation; protein conformation 35502901 0 2 0 -EZH2 EZH2 EC 2.1.1.43; METHYLTRANSFERASE; Methyltransferase; Methyltransferase, protein lysine Q15910 2146 7q36.1 human S220-p 25291187 RPPRKFPsDKIFEAI PRC2_HTH_1 protein stabilization; molecular association, regulation; ubiquitination USP36(INDUCES) 31434700 1 1 1 deubiquitination/inhibit ubiquitination -SLK SLK EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, STE; Protein kinase, Ser/Thr (non-receptor) Q9H2G2 9748 10q24.33-q25.1 human T193-p 1211370 RRDSFIGtPYWMAPE Pkinase enzymatic activity, induced 28475647 1 9 58 -Vav1 VAV1 GEF; GEF, Rac/Rho; Motility/polarity/chemotaxis; Oncoprotein P27870 22324 17 D|17 29.76 cM mouse Y142-p 448809 ALNDEDIySGLSDQI molecular association, regulation; protein conformation; activity, inhibited; phosphorylation cytoskeletal reorganization; transcription, altered; cell growth, altered VAV1(INDUCES) 10669745; 20141838 6 2 0 -ABRAXAS1 Abraxas DNA repair, damage Q6UWZ7 84142 4q21.23 human S406-p 3203163 GFGEYSRsPTF____ molecular association, regulation DNA repair, induced BRCA1(INDUCES) 17525340 2 25 13 Abraxas and RAP80 form a complex that interacts with BRCA1. -Hmgcr HMGCR EC 1.1.1.34; Endoplasmic reticulum; Membrane protein, integral; Membrane protein, multi-pass; Motility/polarity/chemotaxis; Oxidoreductase; Secondary Metabolites Metabolism - terpenoid backbone biosynthesis Q01237 15357 13 D1|13 50.65 cM mouse K248-ub 10844794 VLEEEENkPNPVTQR protein degradation 27129778 3 8 25 -NOX4 NOX4 Cell cycle regulation; EC 1.6.3.-; Membrane protein, integral; Membrane protein, multi-pass; Nucleolus; Oxidoreductase Q9NPH5 50507 11q14.3 human Y491-p 27930805 WQENRPDyVNIQLYL NAD_binding_6 molecular association, regulation cell growth, induced GRB2(INDUCES); SHPS1(INDUCES) 23612968 1 0 0 mediated by Grb2; Grb2 recruitment to SHPS1 -CD3E CD3E Membrane protein, integral; Receptor, misc. P07766 916 11q23.3 human Y188-p 448918 PPVPNPDyEPIRKGQ ITAM molecular association, regulation; phosphorylation NCK2(DISRUPTS); EPS8(DISRUPTS); NCK1(DISRUPTS) 17617578; 18555270; 32317279 5 12 382 -EEF2K EEF2K EC 2.7.11.20; KINASE; Kinase, protein; Protein kinase, Ser/Thr (non-receptor); Protein kinase, atypical; Translation O00418 29904 16p12.2 human S74-p 3150899 ERYSSSGsPANSFHF enzymatic activity, inhibited carcinogenesis, induced; cell growth, induced; translation, induced 35513296 1 29 2 -ITGB4 ITGB4 Cell adhesion; Membrane protein, integral; Motility/polarity/chemotaxis; Receptor, misc. P16144 3691 17q25.1 human Y1564-p 456323 LQGYSVEyQLLNGGE fn3 intracellular localization apoptosis, induced; transcription, induced 23677256 6 0 1 Induce mRNA and protein levels of IL-8, PTGS2, KITLG and ATF3 -GAPDH GAPDH Carbohydrate Metabolism - glycolysis and gluconeogenesis; EC 1.2.1.12; Oxidoreductase P04406 2597 12p13.31 human S122-p 31881707 GAKRVIIsAPSADAP activity, induced; intracellular localization autophagy, induced 26626483 2 4 0 -Ciz1 CIZ1 Cell cycle regulation Q8VEH2 68379 2|2 B mouse T144-p 23094081 LTPPQMVtPNLQQFF molecular association, regulation; activity, inhibited cell cycle regulation CCNA1(DISRUPTS) 25736292 1 0 1 phosphorylation of T293 and T192, T144 are required for interaction with the cyclinA-CDK2 complex and directing it to chromatin -DVL2 DVL2 Adaptor/scaffold; Motility/polarity/chemotaxis O14641 1856 17p13.1 human S597-p 22682200 RSSGSTRsDGGAGRT Dsh_C cytoskeletal reorganization; transcription, inhibited 23396967 2 0 0 neurite outgrowth -Kcnb1 Kv2.1 Channel, cation; Channel, ligand-gated; Channel, potassium; Membrane protein, integral; Membrane protein, multi-pass Q03717 16500 2 H3|2 87.22 cM mouse Y814-p 22874700 FLRPNCVyASEGLPG phosphorylation 33333928 2 1 1 affects the phosphorylation of the site S804 -PANX1 PANX1 Cell adhesion; Membrane protein, integral; Membrane protein, multi-pass Q96RD7 24145 11q21 human Y199-p 462886 KYPIVEQyLKTKKNS Innexin activity, induced; intracellular localization 30814251 2 0 2 induces vasoconstriction -LAX1 LAX1 Adaptor/scaffold; Membrane protein, integral Q8IWV1 54900 1q32.1 human Y268-p 35546002 SSQISNDyVNMTGLD LAX molecular association, regulation transcription, inhibited; signaling pathway regulation GRB2(INDUCES); GADS(INDUCES); PIK3R1(INDUCES) 12359715 1 0 0 -APEX1 APE1 DNA repair, damage; DNA-binding; Deoxyribonuclease; EC 4.2.99.18; Endoplasmic reticulum; Hydrolase; Lyase; Nuclear receptor co-regulator; Nucleolus; Transcription, coactivator/corepressor P27695 328 14q11.2 human K27-ac 15207802 EPEAKKSkTAAKKND acetylation; molecular association, regulation; intracellular localization; protein conformation; enzymatic activity, induced DNA repair, induced; cell growth, induced; cell growth, inhibited NPM1(DISRUPTS); XRCC1(INDUCES) RNA(DISRUPTS) 20699270; 22918947; 27994014 4 2 0 -Eif4ebp1 4E-BP1 Translation; Translation initiation Q62622 116636 16q12.3 rat T45-p 447496 GGTLFSTtPGGTRII eIF_4EBP molecular association, regulation; phosphorylation translation, altered EIF4E(DISRUPTS) 10779345; 20736160; 9806882 156 36 91 -SCN5A SCN5A Channel, sodium; Membrane protein, integral; Membrane protein, multi-pass Q14524 6331 3p22.2 human K1479-ac 63044906 NFNQQKKkLGGQDIF Ion_trans intracellular localization; activity, inhibited 28191886; 32209328 3 2 0 NR decreased current in K1479A SCN5A, but increased INa. Disruption of S1503 site abolished effect on INa.; NR increased current, INa -Neurog2 neurogenin 2 Transcription factor P70447 11924 3|3 G2 mouse S231-p 2255101 SPYSCTLsPASPGSD molecular association, regulation cell growth, altered LDB1(INDUCES) 18400164 2 0 0 important for spinal motor neuron differentiation -RUNX3 AML2 DNA-binding; Transcription factor Q13761 864 1p36.11 human S149-p 6097701 GRSGRGKsFTLTITV Runt protein stabilization; intracellular localization cell cycle regulation; transcription, altered 18767071 1 1 1 -Fto FTO DEMETHYLASE; Demethylase; EC 1.14.11.- Q8BGW1 26383 8 C4-C5|8 44.34 cM mouse S253-p 27449492 CEGSEDEsEDESSFE FTO_NTD protein degradation; ubiquitination 29777057 1 7 0 -SEC23A SEC23A Motility/polarity/chemotaxis Q15436 10484 14q21.1 human S207-p 89117912 LQEMLGLsKVPLTQA Sec23_trunk molecular association, regulation SEC31A(DISRUPTS) 28486929 1 0 0 -Opn4 melanopsin GPCR, family 1; Membrane protein, integral; Membrane protein, multi-pass; Receptor, GPCR Q9QXZ9 30044 14|14 B mouse S395-p 1868515101 STLSSQSsDLSWISG molecular association, regulation; protein conformation ARRB1(INDUCES) 32236094 1 1 0 -P2rx1 P2X1 Channel, ligand-gated; Membrane protein, integral; Membrane protein, multi-pass P51576 18436 11 B4|11 45.09 cM mouse T389-p 26392106 DPAATSStLGLQENM carcinogenesis, induced; cell growth, induced 36418376 2 1 0 -LAT LAT iso2 Adaptor/scaffold; Membrane protein, integral O43561-2 27040 16p11.2 human K204-ub 56394100 ELHPGAAkTEPAALS LAT protein degradation; ubiquitination 27221712 1 0 0 Y132 phosphorylation is required for ubiquitylation. -Slc9a1 NHE1 Membrane protein, integral; Membrane protein, multi-pass; Motility/polarity/chemotaxis; Transporter; Transporter, SLC family P26431 24782 5q36 rat Y561-p 1872043502 LNRFNKKyVKKCLIA activity, inhibited 33585583 1 1 0 -AKAP8 AKAP8 Adaptor/scaffold; Cell cycle regulation; Mitochondrial; RNA-binding O43823 10270 19p13.12 human Y51-p 40420005 SVTTGATySYGPASW molecular association, regulation 25770215 1 0 0 Phenylalanine mutants inhibited dissociation from nuclear structures; structural chromatin changes -ADRB2 ADRB2 GPCR, family 1; Membrane protein, integral; Membrane protein, multi-pass; Receptor, GPCR P07550 154 5q32 human S355-p 458916 KAYGNGYsSNGNTGE receptor internalization, induced; protein degradation; molecular association, regulation; receptor desensitization, altered; intracellular localization; receptor internalization, altered; protein conformation cell motility, induced; signaling pathway regulation ARR3(INDUCES); ARRB2(INDUCES) 11040066; 16407241; 16980556; 18801735; 20193676; 20345371; 21868357; 22275358; 25395624; 31088898 27 2 0 B-arrestin recruitment; B-arrestin mediated signaling -MACROH2A1 H2AFY iso1 DNA-binding O75367-1 9555 5q31.1 human K12-ub 1877384700 GGKKKSTkTSRSAKA Histone intracellular localization DNA repair, induced 32424115 1 0 0 recruiting downstream DNA repair proteins to DNA breaks -DIAPH2 Diaphanous-2 iso4 Cytoskeletal; Motility/polarity/chemotaxis Q17R91 1730 Xq21.33 human T66-p 11147321 ITSFRKStVKKEKPL cell cycle regulation; chromatin organization, altered; cytoskeletal reorganization 21397845 1 0 0 mutation of this site disrupts metaphase chromosome alignment -SUV39H1 SUV39H1 Amino Acid Metabolism - lysine degradation; EC 2.1.1.43; METHYLTRANSFERASE; Methyltransferase; Methyltransferase, protein lysine O43463 6839 Xp11.23 human Y297-p 1867984203 YDRQGATyLFDLDYV SET methylation; enzymatic activity, induced signaling pathway regulation 30833073 1 0 0 NRG-1/ErbB4 signaling -CSNK2B CK2B KINASE; Protein kinase, regulatory subunit P67870 1460 6p21.33 human S4-p 455683 ____MSSsEEVSWIS protein stabilization 12032843 1 9 0 -RACK1 RACK1 Adaptor/scaffold; G protein; G protein, heterotrimeric; G protein, heterotrimeric beta; Motility/polarity/chemotaxis; Nuclear receptor co-regulator P63244 10399 5q35.3 human T50-p 23136904 WKLTRDEtNYGIPQR molecular association, regulation; protein conformation autophagy, induced; transcription, inhibited IRF3(INDUCES); beclin 1(INDUCES); PIK3R4(INDUCES); PIK3C3(INDUCES); IRF7(INDUCES) 26549445; 34348973 3 2 9 induces binding to IRF3/IRF7 thus inhibiting their phosphorylation -C3AR1 C3aR GPCR, family 1; Membrane protein, integral; Membrane protein, multi-pass; Receptor, GPCR Q16581 719 12p13.31 human T463-p 17552878 AAFSEELtRSTHCPS receptor desensitization, induced; molecular association, regulation transcription, inhibited ARRB2(INDUCES) 23077507 1 3 0 -NFATC1 NFAT2 DNA-binding; Transcription factor O95644 4772 18q23 human Y371-p 27427900 ADFAPEDySSFQHIR activity, induced; intracellular localization 23263556 2 1 0 -Opn4 melanopsin GPCR, family 1; Membrane protein, integral; Membrane protein, multi-pass; Receptor, GPCR Q8R456 192223 16p15 rat S381-p 36745800 QRSHPSLsYRSTHRS activity, induced 25378407 3 1 0 increases Ca2+ response -TGFBR2 TGFBR2 EC 2.7.11.30; KINASE; Kinase, protein; Membrane protein, integral; Oncoprotein; Protein kinase, Ser/Thr (receptor); Protein kinase, TKL P37173 7048 3p24.1 human Y424-p 2869602 GQVGTARyMAPEVLE PK_Tyr_Ser-Thr enzymatic activity, induced transcription, altered 9169454 3 0 9 -RBBP8 CtIP EC 3.1.-.-; Transcription, coactivator/corepressor Q99708 5932 18q11.2 human K896-sm 1873173300 SPKGKEQkT______ molecular association, regulation DNA repair, induced DNA(INDUCES) 28740167 1 0 0 -SELL SELL Membrane protein, integral P14151 6402 1q24.2 human S364-p 40548101 RLKKGKKsKRSMNDP molecular association, regulation Calmodulin(DISRUPTS) 25775539 2 0 0 -Ulk1 ULK1 Autophagy; EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, Other; Protein kinase, Ser/Thr (non-receptor) O70405 22241 5|5 F mouse S629-p 27460648 SPTKAGPsFDFPKTP cell cycle regulation; autophagy, induced; cell growth, induced 32516310 1 2 0 -KRT8 K8 Cytoskeletal P05787 3856 12q13.13 human K285-sm 25027600 AESMYQIkYEELQSL Filament cytoskeletal reorganization 21062750 1 3 0 sumoylation regulate solubility; modified by poly-SUMO-2/3 chains, oxidative stress, apoptosis, and/or phosphatase inhibition increase sumoylation in primary hepatocytes; K to R mutants show filament disorganization -XIAP XIAP Apoptosis; EC 6.3.2.-; Ligase; UBIQUITIN LIGASE; Ubiquitin conjugating system; Ubiquitin ligase P98170 331 Xq25 human S87-p 450336 VGRHRKVsPNCRFIN BIR activity, induced; molecular association, regulation; protein stabilization; enzymatic activity, induced carcinogenesis, induced; apoptosis, altered; cell growth, induced; apoptosis, inhibited; autophagy, inhibited; signaling pathway regulation MDM2(INDUCES) 14645242; 17537996; 23749209; 26314849; 30867140; 31493422; 31842909; 32050753 10 0 0 -Pitpna PITPNA Lipid-binding P53810 18738 11 B5|11 45.92 cM mouse S166-p 450933 EDPAKFKsVKTGRGP IP_trans intracellular localization 10801835 2 0 0 Stimulation of NIH3T3 fibroblasts by PMA or PDGF induced the rapid relocalization of PI-TPalpha to perinuclear Golgi structures. -Myd88 MYD88 Adaptor/scaffold P22366 17874 9 F3|9 71.33 cM mouse Y58-p 1876167500 AEEMGFEyLEIRELE Death transcription, induced 35003083 1 0 0 -PRKG1 PKG1 iso2 EC 2.7.11.12; KINASE; Kinase, protein; Protein kinase, AGC; Protein kinase, Ser/Thr (non-receptor) Q13976-2 5592 10q11.23-q21.1 human S81-p 452147 RTKRQAIsAEPTAFD enzymatic activity, induced 12080049 4 0 0 -Crmp1 CRMP-1 Cell development/differentiation; Cytoskeletal; Hydrolase P97427 12933 5 B3|5 19.96 cM mouse T509-p 454314 PVYEVPAtPKHAAPA phosphorylation 29758318 6 18 7 S522A KI mice -PDE4D PDE4D iso6 EC 3.1.4.53; Nucleotide Metabolism - purine; Phosphodiesterase Q08499-6 5144 5q11.2-q12.1 human K48-ub 7388021 EKSKTARkSVSPKLS molecular association, regulation RACK1(DISRUPTS); ARRB1(INDUCES) 19372219 1 0 0 -GTF2A1 GTF2A1 Transcription, coactivator/corepressor P52655 2957 14q31.1 human S321-p 448630 LNSEDDVsDEEGQEL TFIIA transcription, induced 11278496 1 5 2 -ATF4 ATF-4 DNA-binding; Transcription factor P18848 468 22q13.1 human R239-m2 1879738500 PQHSPSTrGSPNRSL protein stabilization 31787756 1 0 0 suppression of ER stress and cell death induced by tunicamycin treatment -SIAH2 SIAH2 EC 6.3.2.-; EC 6.3.2.19; Ligase; Transcription, coactivator/corepressor; UBIQUITIN LIGASE; Ubiquitin conjugating system; Ubiquitin ligase O43255 6478 3q25.1 human T26-p 5393503 PPPQPQHtPSPAAPP protein degradation; molecular association, regulation; intracellular localization; enzymatic activity, induced cytoskeletal reorganization HIPK2(DISRUPTS) 19043406; 22878263; 23044042; 26751770 5 2 0 -MAP1LC3C LC3C Autophagy; Microtubule-binding; Ubiquitin-like modifier; Vesicle Q9BXW4 440738 1q43 human S96-p 1869546301 VNNKSLVsMSATMAE ATG8 molecular association, regulation apoptosis, induced ATG4B(DISRUPTS) 31709703 1 1 0 ; including ATG4A, ATG4C, ATG4D -SP7 osterix C2H2-type zinc finger protein; DNA-binding; Transcription factor Q8TDD2 121340 12q13.13 human K58-ub 31914106 GSDLSASkTMGDAYP protein degradation cell differentiation, inhibited; transcription, inhibited 23457570 2 0 0 -EEF1A1 EEF1A1 Nucleolus; Translation; Translation elongation P68104 1915 6q13 human S300-p 15629200 EMHHEALsEALPGDN GTP_EFTU_D2 molecular association, regulation cell cycle regulation; translation, altered; carcinogenesis, altered; cell growth, altered RNA(NOT_REPORTED) 20832312 1 5 0 inhibits aa-tRNA binding by eEF1A-1 -Creb1 CREB DNA-binding; Transcription factor Q01147 12912 1 C2|1 32.74 cM mouse S107-p 451811 SVDSVTDsQKRREIL pKID intracellular localization 17244605 12 0 0 Preferentially localized to the soluble nucleoplasmic fraction. -DTL RAMP Adaptor/scaffold; DNA repair, damage; DNA replication; UBIQUITIN LIGASE; Ubiquitin conjugating system; Ubiquitin ligase Q9NZJ0 51514 1q32.3 human T464-p 4717290 DLPLPSNtPTFSIKT protein stabilization; molecular association, regulation; ubiquitination cell cycle regulation; cell differentiation, induced 14-3-3 epsilon(INDUCES); FBXO11(DISRUPTS); 14-3-3 gamma(INDUCES) 23478441; 25154416 2 0 2 prevention from polyubiquitination; inhibits ubiquitination -EEF2K EEF2K EC 2.7.11.20; KINASE; Kinase, protein; Protein kinase, Ser/Thr (non-receptor); Protein kinase, atypical; Translation O00418 29904 16p12.2 human S359-p 447826 GTEEKCGsPQVRTLS enzymatic activity, inhibited 11500363; 18337751 6 3 6 -THRA TR-alpha iso2 DNA-binding; Nuclear receptor; Transcription factor P10827-2 7067 17q21.1 human K288-sm 38557703 AVKREQLkNGGLGVV Hormone_recep cell growth, induced; cell differentiation, induced; transcription, induced; signaling pathway regulation 25572392 2 0 0 induces Wnt/?-catenin signaling pathway -HIPK2 HIPK2 EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, CMGC; Protein kinase, Ser/Thr (non-receptor) Q9H2X6 28996 7q34 human S359-p 12119325 HVSKAVCsTYLQSRY Pkinase molecular association, regulation; enzymatic activity, induced apoptosis, induced; signaling pathway regulation ASK1(INDUCES); JNK2(INDUCES) 27321923 1 4 22 HIPK2 and JNK activation -Pgam2 PGAM2 Carbohydrate Metabolism - glycolysis and gluconeogenesis; EC 3.1.3.13; EC 5.4.2.11; EC 5.4.2.4; Isomerase; Phosphatase (non-protein) O70250 56012 11|11 A1 mouse S118-p 4698936 QVKIWRRsFDTPPPP His_Phos_1 protein degradation; molecular association, regulation; ubiquitination MDM2(INDUCES) 24567357 1 5 0 -KIFC1 KIFC1 Microtubule-binding; Motility/polarity/chemotaxis; Motor Q9BW19 3833 6p21.32 human S26-p 477789 RPLIKAPsQLPLSGS protein stabilization; ubiquitination cell cycle regulation; carcinogenesis, induced; DNA repair, induced; chromatin organization, altered 33397932 3 11 36 inhibits ubiquitination -CERT1 COL4A3BP EC 2.7.11.9; KINASE; Kinase, protein; Lipid-binding; Protein kinase, Ser/Thr (non-receptor); Protein kinase, atypical Q9Y5P4 10087 5q13.3 human S144-p 125104502 VSGASGYsATSTSSF molecular association, regulation; activity, inhibited 28652409 0 1 0 reduced PtdIns(4)P binding affinity as well as low ceramide transfer activity, E494R/N495K/P535R/E537K mutations, recovery of both PtdIns(4)P binding and ceramide transfer activity. -Pnma5 PNMA5 Apoptosis Q5DTT8 385377 X|X A7.3 mouse T553-p 125108500 ELRMPTGtEAAQGVE intracellular localization 29228573 1 0 0 regulates meiosis through Akt-GSK3b pathway -Acadvl ACADVL EC 1.3.8.9; Lipid Metabolism - fatty acid; Mitochondrial; Oxidoreductase P50544 11370 11 B3|11 42.96 cM mouse C238-sn 63237400 SSAIPSPcGKYYTLN Acyl-CoA_dh_M enzymatic activity, induced 23281369 1 1 0 -Nrip1 RIP140 Nuclear receptor co-regulator; Transcription, coactivator/corepressor Q8CBD1 268903 16|16 C3.1 mouse R948-m1 2363400 LLSENCVrDLSPHRS NRIP1_repr_4 transcription, induced 19216533 2 2 0 -Zap70 ZAP70 EC 2.7.10.2; KINASE; Kinase, protein; Protein kinase, TK; Protein kinase, tyrosine (non-receptor) P43404 22637 1 B|1 15.41 cM mouse Y314-p 448867 MPMDTSVyESPYSDP protein degradation; molecular association, regulation; ubiquitination; protein conformation; phosphorylation CD3Z(INDUCES); VAV1(INDUCES) 11828374; 26936881; 35860252 12 4 265 -RANBP3 RANBP3 Adaptor/scaffold Q9H6Z4 8498 19p13.3 human S126-p 460735 VKRERTSsLTQFPPS molecular association, regulation; intracellular localization; activity, inhibited RAN(INDUCES) 18280241 3 46 126 inhibits RCC1 activity -Tp53 p53 Activator; DNA-binding; Motility/polarity/chemotaxis; Nuclear receptor co-regulator; Transcription factor; Tumor suppressor P02340 22059 11 B3|11 42.83 cM mouse S312-p 447530 LPTCTSAsPPQKKKP acetylation carcinogenesis, altered; transcription, altered 15794754; 20962274 49 32 7 S312AA knock-in mice are more suseptible to tumorigenesis. ; substitution of either alanine or aspartic acid at this site induces acetylation at K370 (K373 in human) -NBN NBS1 Cell cycle regulation; DNA repair, damage O60934 4683 8q21.3 human K690-ac 487514 KNFKKFKkVTYPGAG Nbs1_C phosphorylation cell cycle regulation; apoptosis, induced; DNA repair, inhibited 17612497; 28869605 3 1 0 -ATP2A2 SERCA2 Cell adhesion; EC 3.6.3.8; Endoplasmic reticulum; Hydrolase; Membrane protein, integral; Membrane protein, multi-pass; Transporter; Transporter, ion channel P16615 488 12q24.11 human K585-sm 25092200 EDSANFIkYETNLTF protein stabilization; molecular association, regulation; ubiquitination; enzymatic activity, induced Other(INDUCES) 21900893 2 0 0 induces ATP binding, inhibits ubiquitination -XRCC1 XRCC1 DNA repair, damage P18887 7515 19q13.31 human S485-p 451510 QDNGAEDsGDTEDEL molecular association, regulation; intracellular localization PARP1(DISRUPTS); Pnk1(INDUCES) 15066279; 25477519 3 16 0 -Magi1 MAGI1 Cell adhesion; Motility/polarity/chemotaxis Q6RHR9 14924 6|6 D1 mouse S733-p 3896422 QPLERKDsQNSSQHS MAGI_u5 activity, induced; intracellular localization 30944250 2 11 35 induces NF-KB and Rap1 activity and EC activation -GYPA GYPA Adaptor/scaffold; Membrane protein, integral P02724 2993 4q31.21 human T36-gl 12726309 TSTSSSVtKSYISSQ Glycophorin_A protein conformation 7681597 1 0 0 The structure or conformation of three consecutive Ser/Thr residues may be necessary for its antigenicity. -GLI3 GLI3 C2H2-type zinc finger protein; Transcription factor P10071 2737 7p14.1 human S907-p 15501388 TDASRRSsEASQSDG protein processing transcription, inhibited 10693759 1 0 0 -SNCA SNCA Adaptor/scaffold P37840 6622 4q22.1 human K96-sm 3755605 AAATGFVkKDQLGKN Synuclein ubiquitination; protein processing apoptosis, inhibited 21746851; 25607946; 29180403 5 1 0 -Wasf1 WAVE1 Cytoskeletal; Motility/polarity/chemotaxis Q5BJU7 rat S441-p 7979602 PPGIRPSsPVTVAAL intracellular localization cytoskeletal reorganization 19460862 4 0 0 -HSPB6 HSP20 Chaperone; Heat shock protein F1RM62 pig S16-p 450706 PSWLRRAsAPLPGLS Crystallin molecular association, regulation ACTG1(INDUCES) 10790164 21 31 2 -THRA TR-alpha DNA-binding; Nuclear receptor; Transcription factor NP_990644 396251 chicken K387-sm 27490405 ASRFLHMkVECPTEL Hormone_recep molecular association, regulation transcription, altered Src(INDUCES); N-CoR1(INDUCES) DNA(DISRUPTS) 27843805 3 0 0 -Irx3 IRX3 DNA-binding P81067 16373 8 C5|8 44.55 cM mouse S361-p 1874748504 SLAETATsPDNPRRS molecular association, regulation; intracellular localization transcription, induced IRX3(INDUCES) 34556885 1 1 0 IRX3 dimerization, nuclear translocation -AFP AFP Secreted; Secreted, signal peptide P02771 174 4q13.3 human K194-ac 1879738503 KIIPSCCkAENAVEC ubiquitination carcinogenesis, induced; cell motility, induced; cell growth, induced; apoptosis, inhibited 31811908 1 1 0 inhibits ubiquitination, promotes the migration and invasion -Cacna1b CACNA1B Channel, calcium; Membrane protein, integral; Membrane protein, multi-pass Q02294 257648 3p13 rat S2132-p 465550 YSCDRFGsREPPQPK activity, induced 16704976; 19167461 2 0 0 -TWIST1 TWIST1 Cell development/differentiation; DNA-binding; Inhibitor; Transcription regulation Q15672 7291 7p21.1 human S68-p 18905000 GGGDEPGsPAQGKRG molecular association, regulation; protein stabilization; ubiquitination; intracellular localization carcinogenesis, induced; carcinogenesis, altered; cell motility, induced; apoptosis, inhibited; transcription, induced; transcription, altered E2A(INDUCES); NFkB-p65(INDUCES) 21502402; 26959880; 26975371; 31540485; 34881782 5 13 0 protects Twist1 from ubiquitination; ; upregulates expression of POSTN and PDGFRa; inhibits ubiquitination; promotes TGFbeta-induced cell invasion -NCOA3 SRC-3 ACETYLTRANSFERASE; Acetyltransferase; EC 2.3.1.48; Motility/polarity/chemotaxis; Nuclear receptor co-regulator; Transcription, coactivator/corepressor Q9Y6Q9 8202 20q13.12 human Y1357-p 4668109 HPQAASIyQSSEMKG molecular association, regulation transcription, altered; cell growth, altered p300(INDUCES); CARM1(INDUCES); ER-alpha(INDUCES) 18765637 1 1 0 -PLCG1 PLCG1 Carbohydrate Metabolism - inositol phosphate; EC 3.1.4.11; Motility/polarity/chemotaxis; Phospholipase P19174 5335 20q12 human K54-sm 1879811200 ERKTFQVkLETRQIT activity, induced; molecular association, regulation; phosphorylation SLP76(INDUCES); GADS(INDUCES) 30873169 1 0 0 T-cell activation, microcluster formation and Ca2+ flux, slightly promotes phosphorylation of Y783 -PTK2 FAK EC 2.7.10.2; KINASE; Kinase, protein; Protein kinase, TK; Protein kinase, tyrosine (non-receptor) Q00944 396416 chicken Y397-p 447887 SVSETDDyAEIIDEE molecular association, regulation Src(INDUCES) 10816598; 7509446 371 31 474 -Rap1gap RAP1GAP GAP; GAP, Ras; Motility/polarity/chemotaxis XP_233609 313644 5q36 rat S472-p 1210678 VIRSRSQsMDAMGLS cytoskeletal reorganization 19218462 1 19 72 controls dendritic spine morphology -SLC6A4 SERT Membrane protein, integral; Membrane protein, multi-pass; Transporter P31645 6532 17q11.2 human S611-p 7576400 FKERIIKsITPETPT activity, induced; molecular association, regulation Vimentin(DISRUPTS) 19270731 1 0 1 -TRAF6 TRAF6 EC 6.3.2.-; Ligase; UBIQUITIN LIGASE; Ubiquitin conjugating system; Ubiquitin ligase Q9Y4K3 7189 11p12 human Y288-p 1869056900 SVIPDSGyISEVRNF activity, induced; ubiquitination TAK1(INDUCES); TAB2(INDUCES) 32403971 2 0 0 -HMGN2 HMGN2 DNA-binding P05204 3151 1p36.11 human S25-p 3146800 KDEPQRRsARLSAKP HMG14_17 intracellular localization 10739259 2 12 5 Phosphorylation facilitates localization to non-nuclear pools. -Scarb1 SCARB1 Membrane protein, integral; Membrane protein, multi-pass; Receptor, misc. P97943 25073 12q15 rat K508-ub 21184146 GTVLQEAkL______ protein degradation 28669731 1 3 0 -PREX1 PREX1 GEF; GEF, Rac/Rho Q8TCU6 57580 20q13.13 human S1165-p 25256104 DSGHDTMsYRDSYSE enzymatic activity, inhibited 22242915 1 1 0 -CDC6 CDC6 Cell cycle regulation Q99741 990 17q21.2 human K105-ac 8539501 FDNQLTIkSPSKREL intracellular localization cell cycle regulation 19343071 1 0 0 -Trpv1 TRPV1 Channel, cation; Membrane protein, integral; Membrane protein, multi-pass; Receptor, misc. O35433 83810 10q24 rat T406-p 473576 IAYSSSEtPNRHDML receptor desensitization, inhibited; molecular association, regulation; intracellular localization; protein conformation; activity, inhibited; phosphorylation KIF13B(INDUCES) 17194758; 26376215; 26902776 5 0 0 modulates oral pain related responses transduced via the TRPV1 channel, response of TRPV1 to heat is altered in the T406D mutant, modulates voltage-dependence -Hcn4 HCN4 Channel, cation; Membrane protein, integral; Membrane protein, multi-pass O70507 330953 9|9 B mouse T1138-p 15103405 HVTLPRKtSSGSLPP activity, induced 20713547 1 0 0 required for PKA to shift the voltage dependence of HCN4 -RAPGEF2 RAPGEF2 GEF; GEF, Ras; Motility/polarity/chemotaxis Q9Y4G8 9693 4q32.1 human S1244-p 30995201 ASLDAADsGRGSWTS protein degradation; molecular association, regulation; ubiquitination; enzymatic activity, inhibited carcinogenesis, induced; cell motility, induced BTRC(INDUCES) 24290981 1 0 0 inhibits Rap1 activity -PPARG PPAR-gamma DNA-binding; Nuclear receptor; Transcription factor P37231 5468 3p25.2 human K395-sm 12004433 FGDFMEPkFEFAVKF Hormone_recep carcinogenesis, inhibited; cell growth, inhibited; transcription, induced; transcription, altered 25409419; 26244663; 29137280 8 0 0 transcription of a subset of PPAR-gamma target genes involved in lipid metabolism -CREBBP CBP ACETYLTRANSFERASE; Acetyltransferase; DNA-binding; EC 2.3.1.48; Motility/polarity/chemotaxis; Nuclear receptor co-regulator; Transcription, coactivator/corepressor Q92793 1387 16p13.3 human R714-me 475950 PLSLPVNrMQVSQGM transcription, induced; signaling pathway regulation 12374746 1 0 0 steroid hormone signaling, GRIP1 and steroid hormone-induced transcription -RIOK2 RIOK2 EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, Ser/Thr (non-receptor); Protein kinase, atypical Q9BVS4 55781 5q15 human S380-p 3211080 PEQIKEDsLSEESAD cell cycle regulation 21880710 1 29 6 -Slitrk3 SLITRK3 Cell surface; Membrane protein, integral Q810B9 386750 3|3 E3 mouse Y969-p 465425 KLQTKPDyLEVLEKT molecular association, regulation gephyrin(INDUCES) 31551708 1 0 1 regulates synapse development -CHFR CHFR EC 6.3.2.-; EC 6.3.2.19; Ligase; UBIQUITIN LIGASE; Ubiquitin conjugating system; Ubiquitin ligase Q96EP1 55743 12q24.33 human K663-sm 27992500 ICEQTRFkN______ protein degradation cell growth, induced 23131550 1 0 0 -Itgb1 ITGB1 Cell adhesion; Cell surface; Membrane protein, integral; Motility/polarity/chemotaxis; Receptor, misc. P09055 16412 8|8 E2 mouse S785-p 452040 GENPIYKsAVTTVVN Integrin_b_cyt cell adhesion, altered 19555977 5 11 17 -TARDBP TDP-43 RNA-binding Q13148 23435 1p36.22 human S403-p 3084617 GFNGGFGsSMDSKSS molecular association, regulation; intracellular localization; phosphorylation RNA splicing, inhibited; RNA stability, inhibited TDP-43(DISRUPTS) 22198567; 24466128; 34107054; 35112738 14 3 0 primes phosphorylation at other sites; promotes cytoplasmic aggregation -Slc4a3 SLC4A3 Membrane protein, integral; Membrane protein, multi-pass; Transporter; Transporter, SLC family P23348 24781 9q33 rat S67-p 10212000 EKPSRSYsERDFEFH activity, induced 11739292; 28677776 2 1 0 SLC4A3 exchange activity, inhibits H/R-induced ROS production -Sdc2 syndecan-2 Cell adhesion; Cell surface; Membrane protein, integral; Motility/polarity/chemotaxis P34900 25615 7q22 rat Y179-p 448375 RKKDEGSyDLGERKP Syndecan molecular association, regulation cytoskeletal reorganization EphB2(INDUCES) 11580899 2 2 6 -DPYSL5 CRMP-5 Q9BPU6 56896 2p23.3 human T516-p 478232 TPLADTPtRPVTRHG molecular association, regulation cell growth, inhibited TUBA1A(INDUCES) 25040932 1 2 0 -TRAF2 TRAF2 Autophagy; EC 6.3.2.-; Ligase; UBIQUITIN LIGASE; Ubiquitin conjugating system; Ubiquitin ligase Q12933 7186 9q34.3 human S11-p 5397201 ASVTPPGsLELLQPG activity, induced; molecular association, regulation; ubiquitination carcinogenesis, induced; cell growth, induced; apoptosis, inhibited; signaling pathway regulation RIPK1(INDUCES); IKKB(INDUCES); cIAP1(DISRUPTS); IKKG(INDUCES) 18981220; 23007157; 24362534 6 15 0 -ATAD3A ATAD3A iso2 Mitochondrial Q9NVI7-2 55210 1p36.33 human K135-ac 11322823 ARAQYQDkLARQRYE ATAD3_N molecular association, regulation; activity, inhibited ATAD3A(DISRUPTS) 30914652 1 3 1 dimerization of ATAD3A is promoted by deacetylation of ATAD3A and Drp1-mediated mitochondrial fragmentation -HIF1A HIF1A Autophagy; DNA-binding; Transcription factor Q16665 3091 14q23.2 human K477-ub 21176130 LNQEVALkLEPNPES protein degradation carcinogenesis, inhibited; cell motility, inhibited; transcription, inhibited 29180628 2 3 0 -INSR INSR EC 2.7.10.1; KINASE; Kinase, protein; Membrane protein, integral; Protein kinase, TK; Protein kinase, tyrosine (receptor) P06213 3643 19p13.2 human S1033-p 454090 LRELGQGsFGMVYEG PK_Tyr_Ser-Thr phosphorylation 10819237 5 0 0 alanine mutations of S1033, S1062, and S1064 increases tyrosine autophosphorylation of InsR -NRG1 NRG1 iso6 Cell development/differentiation; Cytokine; Ligand, receptor tyrosine kinase; Membrane protein, integral; Motility/polarity/chemotaxis Q02297-6 3084 8p12 human S286-p 28076401 LHDRLRQsLRSERNN Neuregulin protein processing 23720309 2 2 0 induced cleavage -RPS6KA5 MSK1 EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, AGC; Protein kinase, Ser/Thr (non-receptor) O75582 9252 14q32.11 human S360-p 448215 TEMDPTYsPAALPQS Pkinase_C protein conformation; enzymatic activity, induced 17446865 6 1 15 -Syt2 SYT2 Calcium-binding; Lipid-binding; Membrane protein, integral; Vesicle P46097 20980 1 E4|1 58.24 cM mouse T202-p 454031 ETKVHRKtLNPAFNE C2 molecular association, regulation 15350218 1 0 0 phosphorylation of this site modulates synaptotagmin II binding to phospholipid vesicles (via its C2 domain) -Mafa MAFA DNA-binding; Oncoprotein; Transcription factor; Tumor suppressor Q8CF90 378435 15|15 D3 mouse S61-p 1320401 PLSTPCSsVPSSPSF protein degradation; molecular association, regulation transcription, inhibited MAFA(INDUCES); PSME3(INDUCES) DNA(NOT_REPORTED) 20208071; 21646385 4 0 0 -TEC TEC EC 2.7.10.2; KINASE; Kinase, protein; Protein kinase, TK; Protein kinase, tyrosine (non-receptor) P42680 7006 4p12-p11 human Y519-p 447891 RYVLDDQyTSSSGAK PK_Tyr_Ser-Thr enzymatic activity, induced 14679216 1 20 322 autophosphorylation site 519F mutant is unable to phosphorylate BDP1 -Socs3 SOCS3 Inhibitor O35718 12702 11|11 E2 mouse Y221-p 450447 IREFLDQyDAPL___ cell cycle regulation; carcinogenesis, inhibited; cell growth, inhibited 31255914 4 0 0 -PTPN1 PTP1B EC 3.1.3.48; Motility/polarity/chemotaxis; PHOSPHATASE; Phosphatase; Protein phosphatase, tyrosine (non-receptor) P18031 5770 20q13.13 human Y153-p 449314 SEDIKSYyTVRQLEL Y_phosphatase molecular association, regulation INSR(INDUCES) 8999839 2 0 0 -HSP90AA1 HSP90A Chaperone; Heat shock protein P07900 3320 14q32.31 human K419-ac 33362015 IRKNLVKkCLELFTE HSP90 molecular association, regulation apoptosis, induced TSC1(INDUCES) 31645902 1 1 0 -BMAL1 BMAL1 DNA-binding; Transcription factor O00327 406 11p15.3 human K259-sm 3055600 KCNRPSVkVEDKDFP protein degradation; intracellular localization transcription, induced 18644859 2 1 0 -EDC4 EDC4 RNA processing Q6P2E9 23644 16q22.1 human S107-p 23101593 IVASSDSsISSKARG RNA stability, altered 30467221 1 0 1 increase formation of P bodies -DRD2 DRD2 iso2 GPCR, family 1; Membrane protein, integral; Membrane protein, multi-pass; Receptor, GPCR P14416-2 1813 11q23.2 human S228-p 487432 KRVNTKRsSRAFRAH 7tm_1 receptor desensitization, induced; receptor recycling, induced 23082996 2 0 0 PKC mediated receptor desensitization and internalization -Pdcd1 PD-1 Apoptosis; Membrane protein, integral Q02242 18566 1|1 D mouse Y248-p 50293001 TACVHTEyATIVFTE molecular association, regulation cell differentiation, altered; carcinogenesis, induced; cell growth, induced; transcription, altered SHP-2(INDUCES) 26359984; 36581713 4 0 0 -PKM PKM Carbohydrate Metabolism - glycolysis and gluconeogenesis; Carbohydrate Metabolism - pyruvate; EC 2.7.1.40; KINASE; Kinase, other; Mitochondrial; Nucleotide Metabolism - purine P14618 5315 15q23 human K311-sc 33357166 EKVFLAQkMMIGRCN PK protein conformation; enzymatic activity, induced 28614718 1 1 0 Promotes PKM2 Tetramer-to-Dimer Transition and Protein Kinase Activity -Zc3h12a MCPIP1 EC 3.1.-.-; Hydrolase Q5D1E7 230738 4|4 D2.2 mouse S439-p 22730006 CLDSGIGsLESQMSE protein degradation; molecular association, regulation; ubiquitination; phosphorylation RNA stability, induced; transcription, induced BTRC(INDUCES) 22037600; 31072819; 34636324 3 1 0 phosphorylation followed by degradation of ZC3H12A (aka regnase-1) augments IL-6 mRNA stability; induces phosphorylation of STAT3 -TOP1 TOP1 EC 5.99.1.2; Isomerase; Nucleolus; Oncoprotein P11387 7150 20q12 human K103-sm 2793908 ASGDAKIkKEKENGF intracellular localization 12149243 2 1 0 -BLM BLM DNA repair, damage; DNA replication; EC 3.6.4.12; Helicase P54132 641 15q26.1 human S144-p 467079 KKLEFSSsPDSLSTI BLM_N cell cycle regulation 16864798 1 5 2 prevents early mitotic exit, necessary for mitotic arrest -IP6K2 IHPK2 EC 2.7.4.21; Kinase, other; Motility/polarity/chemotaxis Q9UHH9 51447 3p21.31 human S347-p 478422 RPEVVLDsDAEDLED IPK protein degradation; ubiquitination apoptosis, induced; cell growth, altered TRAF2(INDUCES) DNA(INDUCES) 17379600; 21262846 2 2 0 induces NFkB-DNA binding -FUS hnRNP P2 DNA-binding; Nuclear receptor co-regulator; Oncoprotein; RNA splicing; RNA-binding; SUMO LIGASE P35637 2521 16p11.2 human S277-p 1232880 DQGSRHDsEQDNSDN molecular association, regulation hnRNP P2(DISRUPTS) 35753345 1 9 2 -KIF23 KIF23 iso2 Microtubule-binding; Motility/polarity/chemotaxis; Motor Q02241-2 9493 15q23 human S708-p 2902205 IRLRHRRsRSAGDRW MKLP1_Arf_bdg activity, induced; intracellular localization cell cycle regulation; cytoskeletal reorganization 20451386; 30728176 5 1 0 induce centralspindlin oligomerization, RhoA activation and cytokinesis initiation. Prevent furrow regression -Ezh2 EZH2 EC 2.1.1.43; METHYLTRANSFERASE; Methyltransferase; Methyltransferase, protein lysine Q61188 14056 6 B2.3|6 22.92 cM mouse T416-p 10417699 EANSRCQtPIKMKPN activity, induced carcinogenesis, induced 31704972 5 7 7 supresses ER alpha expression -Ksr1 KSR KINASE; Kinase, protein; Protein kinase, Ser/Thr (non-receptor); Protein kinase, TKL Q61097 16706 11 B5|11 46.74 cM mouse Y728-p 3428057 LSHDWLCyLAPEIVR PK_Tyr_Ser-Thr protein stabilization; molecular association, regulation; protein conformation; phosphorylation; enzymatic activity, induced cell growth, inhibited BRAF iso1(DISRUPTS); MEK1(INDUCES) 24158441 1 1 0 delay cell proliferation, increases MEK activation and phosphorylation by BRAF -Myo3a MYO3A Actin-binding; EC 2.7.11.1; KINASE; Kinase, protein; Motor; Protein kinase, STE; Protein kinase, Ser/Thr (non-receptor) Q8K3H5 667663 2|2 A3 mouse S177-p 36841902 GVSAQLSsTRHRLNT Pkinase enzymatic activity, induced 21895655 2 2 0 -IL10RA IL10RA Membrane protein, integral; Receptor, cytokine Q13651 3587 11q23.3 human Y446-p 449607 AAVAFQGyLRQTRCA molecular association, regulation CSRP1(INDUCES) 12802285 2 0 0 -Fus hnRNP P2 DNA-binding; Nuclear receptor co-regulator; Oncoprotein; RNA splicing; RNA-binding; SUMO LIGASE P56959 233908 7|7 F3 mouse Y6-p 1869633701 __MASNDyTQQATQS intracellular localization 32678881 1 0 0 Induce fibrotic signaling -BECN1 beclin 1 Adaptor/scaffold; Autophagy; Membrane protein, peripheral Q14457 8678 17q21.31 human Y352-p 28850301 KSKELPLyCSGGLRF APG6 molecular association, regulation cell differentiation, inhibited; carcinogenesis, induced; autophagy, inhibited Bcl-2(INDUCES); beclin 1(INDUCES); rubicon(INDUCES); PIK3C3(DISRUPTS) 24034250; 29610308 2 0 0 kinase active HER2 -Prkd1 PRKD1 Autophagy; EC 2.7.11.13; KINASE; Kinase, protein; Motility/polarity/chemotaxis; Protein kinase, CAMK; Protein kinase, Ser/Thr (non-receptor) Q9WTQ1 85421 6q22 rat S744-p 448589 ARIIGEKsFRRSVVG Pkinase enzymatic activity, induced 11410586 58 14 20 -Cdk16 CDK16 Cell cycle regulation; EC 2.7.11.22; KINASE; Kinase, protein; Motility/polarity/chemotaxis; Protein kinase, CMGC; Protein kinase, Ser/Thr (non-receptor) Q04735 18555 X A1.3|X 16.18 cM mouse S119-p 453450 EDINKRLsLPADIRL molecular association, regulation CCNYL1(INDUCES) 26305884 4 60 0 -DVL3 DVL3 Motility/polarity/chemotaxis Q92997 1857 3q27.1 human S612-p 3830508 SDHTTRSsLRGPRER Dsh_C intracellular localization 24993822 1 1 1 -TGM2 TGM2 EC 2.3.2.13; KINASE; Transferase P21980 7052 20q11.23 human S212-p 22636600 KNAGRDCsRRSSPVY signaling pathway regulation 22142843 1 0 0 activation of Akt-signaling pathway, downregulation of EGFR -PPP1R16B PPP1R16B Motility/polarity/chemotaxis; Protein phosphatase, regulatory subunit Q95N27 282091 cow S337-p 486245 SSLSRRTsSAGSRGK cytoskeletal reorganization 17609201 2 0 0 -Gata1 GATA1 DNA-binding; Transcription factor P17679 14460 X A1.1|X 3.59 cM mouse S72-p 451234 EAEAYRHsPVFQVYP protein degradation; acetylation; ubiquitination; phosphorylation DNA(INDUCES) 16858405 3 0 2 Phosphorylation and acetylation cause the degradation of acetylated GATA-1; DNA binding is required for MAPK-dependent phosphorylation -TP53 p53 Activator; DNA-binding; Motility/polarity/chemotaxis; Nuclear receptor co-regulator; Transcription factor; Tumor suppressor P04637 7157 17p13.1 human K321-ne 486298 SSPQPKKkPLDGEYF P53_tetramer activity, inhibited transcription, inhibited 17098746 1 0 0 -HECTD3 HECTD3 EC 6.3.2.-; EC 6.3.2.19; Ligase; UBIQUITIN LIGASE; Ubiquitin conjugating system; Ubiquitin ligase Q5T447 79654 1p34.1 human S95-p 150180310 PLRAARDsIELRRGA molecular association, regulation apoptosis, inhibited CASP9(INDUCES) 28716524 1 1 0 -Erbb3 HER3 EC 2.7.10.1; KINASE; Kinase, protein; Membrane protein, integral; Oncoprotein; Protein kinase, TK; Protein kinase, tyrosine (receptor) Q62799 29496 7q11 rat Y1273-p 449857 AGGAGGDyAAMGACP molecular association, regulation; phosphorylation PIK3CB(INDUCES); PIK3R1(INDUCES) 11546794 3 6 57 induces phosphorylation of Akt1. -PPM1D PPM1D Cell cycle regulation; EC 3.1.3.16; Motility/polarity/chemotaxis; Nuclear receptor co-regulator; PHOSPHATASE; Protein phosphatase, Ser/Thr (non-receptor) O15297 8493 17q23.2 human S85-p 28847901 PLPDAGAsPAPSRCC PP2C protein degradation; ubiquitination DNA repair, induced; signaling pathway regulation 23871434 1 7 0 protein stabilization takes place after IR treatment and ATM activation -ETV6 Tel DNA-binding; Motility/polarity/chemotaxis; Oncoprotein; Transcription factor P41212 2120 12p13.2 human K99-sm 2884400 KALLLLTkEDFRYRS SAM_PNT intracellular localization transcription, induced; transcription, inhibited 12626745; 18022807 2 0 0 -MAFG MAFG Cell cycle regulation; DNA-binding O15525 4097 17q25.3 human K71-ac 458966 YAASCRVkRVTQKEE bZIP_Maf molecular association, regulation DNA(INDUCES) 11154691 1 0 0 -MAPK7 ERK5 EC 2.7.11.24; KINASE; Kinase, protein; Protein kinase, CMGC; Protein kinase, Ser/Thr (non-receptor) Q13164 5598 17p11.2 human S720-p 3195185 VTQQLSKsQVEDPLP intracellular localization; enzymatic activity, inhibited transcription, altered 20667468 1 6 0 -UVRAG UVRAG Autophagy Q9P2Y5 7405 11q13.5 human S571-p 7447346 KGEDLVGsLNGGHAN enzymatic activity, induced 26139536 1 7 0 alters lysosomal morphology and lysosomal tubulation -Yap1 YAP1 Oncoprotein; Transcription, coactivator/corepressor P46938 22601 9|9 A1 mouse S352-p 471290 GTPNAVSsPGMSQEL intracellular localization cell cycle regulation; cytoskeletal reorganization; signaling pathway regulation 33046882 8 29 12 Hippo pathway -RBM24 RBM24 Q9BX46 221662 6p22.3 human S181-p 556485000 DQYPYAAsPAAAGYV translation, induced 29358667 1 0 0 p53 expression -CAV2 caveolin-2 Adaptor/scaffold; Motility/polarity/chemotaxis P51636 858 7q31.2 human Y27-p 454430 SHHSGLEyADPEKFA Caveolin intracellular localization; phosphorylation cell growth, induced; transcription, inhibited 15504032; 22819829 6 9 33 Smad3 phosphorylation inhibited, PAI-1 protein expression supressed -Shank3 SHANK3 Adaptor/scaffold Q9JLU4 59312 7q34 rat S685-p 3844913 PPPKRAPsTTLTLRS molecular association, regulation Abi-1(INDUCES); Abi-2(INDUCES) 30610205; 31983435 2 5 1 -RET Ret EC 2.7.10.1; KINASE; Kinase, protein; Membrane protein, integral; Oncoprotein; Protein kinase, TK; Protein kinase, tyrosine (receptor) P07949 5979 10q11.21 human K1107-ub 31839904 MLSPSAAkLMDTFDS protein degradation; phosphorylation 24425877 1 0 0 Y341 phosphorylation increases Ret ubquitylation -Nfkbia IkB-alpha DNA-binding; Inhibitor Q63746 25493 6q23 rat S32-p 448203 LVDDRHDsGLDSMKD activity, induced; intracellular localization apoptosis, altered; transcription, induced; transcription, altered 11490015; 16316997; 16407217; 35842713 161 3 17 A S32A,S36A double mutant of IkBA inhibits the NFkB/p65-induced increase in dor (delta opiod receptor) promoter transcription; Cells expressing IKBa S32A S36A are more susceptible to apoptosis while in suspension than cells expressing wt IKBa.; inhibits nuclear translocation of p65-p50 -Stat4 STAT4 DNA-binding; Transcription factor P42228 20849 1 C1.1|1 26.67 cM mouse S722-p 447789 PSDLLPMsPSAYAVL activity, induced cell differentiation, altered; transcription, altered 10961885; 12213961 5 3 0 -SOX10 SOX10 Cell development/differentiation; DNA-binding; Transcription factor P56693 6663 22q13.1 human T244-p 628303300 GPPTPPTtPKTELQS sumoylation; molecular association, regulation; activity, inhibited transcription, inhibited UBC9(DISRUPTS) 29295999 2 2 0 inhibits sumoylation -AURKC AurC EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, Other; Protein kinase, Ser/Thr (non-receptor) Q9UQB9 6795 19q13.43 human T198-p 455456 TPSLRRKtMCGTLDY Pkinase enzymatic activity, induced 27332895 7 11 83 -GAB1 GAB1 Adaptor/scaffold; Motility/polarity/chemotaxis Q13480 2549 4q31.21 human Y472-p 447947 EPIQEANyVPMTPGT molecular association, regulation SHP-2(INDUCES); PIK3R1(INDUCES) 10978177; 9658397 7 0 2 -TRIM65 TRIM65 Ubiquitin conjugating system Q6PJ69 201292 17q25.1 human S367-p 1868914502 RGPGGPGsFELWQVQ carcinogenesis, inhibited; signaling pathway regulation 31332286 1 1 0 dephosphorylated form (6A mutant) contributes to TRIM65 function in tumor progression -KIF23 KIF23 Microtubule-binding; Motility/polarity/chemotaxis; Motor Q02241 9493 15q23 human S812-p 2902205 IRLRHRRsRSAGDRW MKLP1_Arf_bdg molecular association, regulation LIMK1(INDUCES) 25786116 5 1 0 activation of LIMK1 on centrosomes -NR1H4 NR1H4 iso2 DNA-binding; Nuclear receptor Q96RI1-2 9971 12q23.1 human T442-p 3333402 GRLTELRtFNHHHAE Hormone_recep activity, induced; intracellular localization 18668687 1 0 1 -KIF4A KIF4A Microtubule-binding; Motor O95239 24137 Xq13.1 human S1186-p 459846 KKTPPAPsPFDLPEL molecular association, regulation; intracellular localization cell cycle regulation; chromatin organization, altered CNAP1(INDUCES); SMC2L1(INDUCES) 30576375 1 15 3 chromosome binding and scaffold formation -Dlg1 DLG1 Adaptor/scaffold; Motility/polarity/chemotaxis Q62696 25252 11q22 rat S442-p 5931300 YLGQTPAsPARYSPI PDZ_assoc molecular association, regulation; intracellular localization cytoskeletal reorganization GKAP1(DISRUPTS) 15729360 3 2 10 -PPP2R2B PPP2R2B iso2 Apoptosis; Mitochondrial; Motility/polarity/chemotaxis; Protein phosphatase, regulatory subunit Q00005-2 5521 5q32 human S22-p 25554902 PNTILSSsCHTEADI intracellular localization; phosphorylation apoptosis, inhibited 22583914 1 0 0 induces phosphorylation of Drp1 and regulates mitochondrial fragmentation and OMM translocation of beta B2 -Tp53 p53 Activator; DNA-binding; Motility/polarity/chemotaxis; Nuclear receptor co-regulator; Transcription factor; Tumor suppressor P10361 24842 10q24 rat S15-p 447490 MSIELPLsQETFSCL P53_TAD protein stabilization; intracellular localization apoptosis, induced 12534344; 34529316; 35390676; 35917315 480 12 0 -Cdk4 CDK4 Cell cycle regulation; EC 2.7.11.22; KINASE; Kinase, protein; Protein kinase, CMGC; Protein kinase, Ser/Thr (non-receptor) P30285 12567 10|10 D3 mouse T172-p 448476 YSYQMALtPVVVTLW Pkinase enzymatic activity, induced 8139570 12 4 3 -CCDC106 CCDC106 Q9BWC9 29903 19q13.42 human S147-p 1867984200 SGASEEGsASERRRQ CCDC106 molecular association, regulation; intracellular localization carcinogenesis, induced; cell motility, induced; cell growth, induced; apoptosis, inhibited; signaling pathway regulation p53(INDUCES) 30885251 1 0 0 -Shc1 SHC1 iso2 Adaptor/scaffold; Apoptosis; Mitochondrial; Motility/polarity/chemotaxis P98083-2 20416 3 F1|3 39.11 cM mouse Y240-p 448510 EPPDHQYyNDFPGKE molecular association, regulation; phosphorylation cell motility, induced; cell motility, altered GRB2(INDUCES) 18273058; 23277357 29 22 943 angiogenesis; required for ErbB2- and TGFB mediated tumor metastasis to the lungs.; metastatic spread of tumors; required for migration and invasion of ERB2-expressing cells -KDR VEGFR2 EC 2.7.10.1; KINASE; Kinase, protein; Membrane protein, integral; Protein kinase, TK; Protein kinase, tyrosine (receptor) P35968 3791 4q12 human Y996-p 447904 EEAPEDLyKDFLTLE PK_Tyr_Ser-Thr molecular association, regulation; receptor internalization, altered; enzymatic activity, induced signaling pathway regulation PLCG1(INDUCES) 10102632; 25119572 7 0 0 -SRC Src EC 2.7.10.2; KINASE; Kinase, protein; Oncoprotein; Protein kinase, TK; Protein kinase, tyrosine (non-receptor) P12931 6714 20q11.23 human S104-p 8149769 SRTETDLsFKKGERL SH3_1 protein degradation; molecular association, regulation FBXL7(INDUCES); FBW1B(DISRUPTS) 32839549 1 4 1 -Ctnnd1 CTNND1 Actin-binding; Adaptor/scaffold; Cell adhesion; G protein regulator, misc.; Motility/polarity/chemotaxis P30999 12388 2 D|2 49.45 cM mouse S288-p 450452 GLEDDQRsMGYDDLD molecular association, regulation; intracellular localization carcinogenesis, induced; cell adhesion, inhibited Kaiso(INDUCES) 21468542; 26175155 7 35 27 decreased homophilic binding affinity of E-cadherin -TP53 p53 Activator; DNA-binding; Motility/polarity/chemotaxis; Nuclear receptor co-regulator; Transcription factor; Tumor suppressor P04637 7157 17p13.1 human S6-p 447537 __MEEPQsDPSVEPP P53_TAD activity, induced; molecular association, regulation; acetylation; protein conformation; phosphorylation apoptosis, altered; apoptosis, induced; transcription, induced; transcription, altered 11875057; 12860987; 14665630; 15471885; 18769132; 18794113; 21454683 34 2 1 increased p21 expression -ANK3 ANK3 Adaptor/scaffold; Motility/polarity/chemotaxis Q12955 288 10q21.2 human S2417-p 38552200 SRVNTPVsQEEDSRP molecular association, regulation SPTBN4(INDUCES) 25552556 1 0 0 -Abra ABRA Actin-binding; Contractile; Transcription, coactivator/corepressor Q8K4K7 286965 7q31 rat T62-p 1255792402 ATQDLPHtPKEPGPR transcription, induced 30210579 1 1 0 -STIL STIL Cell cycle regulation; Cell development/differentiation; Oncoprotein Q15468 6491 1p33 human S1108-p 17549173 DRSTVGLsLISPNNM molecular association, regulation; intracellular localization cytoskeletal reorganization SAS6(INDUCES) 26101219 1 1 0 promotes centriole duplication, centriole recruitment of STIL -GALNT2 GALNT2 EC 2.4.1.41; Glycan Metabolism - O-glycan biosynthesis; Membrane protein, integral; Transferase Q10471 2590 1q42.13 human S109-ac 25336511 NKFNQVEsDKLRMDR enzymatic activity, inhibited; O-GalNAc glycosylation 21651894 0 1 0 inhibits glycosylation of mucin -OPA1 OPA1 Apoptosis; EC 3.6.5.5; Hydrolase; Membrane protein, integral; Mitochondrial O60313 4976 3q29 human K926-ac 31068000 EDGEKKIkLLTGKRV OPA1_C enzymatic activity, inhibited 24344202 1 1 0 regulation of mitochondrial dynamics, morphology and function -Sh3bp2 SH3BP2 Adaptor/scaffold Q06649 24055 5|5 B2 mouse Y446-p 449093 EEDSDEDyEKVPLPN molecular association, regulation LYN(INDUCES) 12709437 5 0 0 over expression of SH3BP2 leads to Lyn autophosphorylation -Txnip TXNIP Apoptosis; Mitochondrial; Motility/polarity/chemotaxis; Tumor suppressor Q8BG60 56338 3 F2.1|3 41.93 cM mouse S309-p 277409200 GLSSRTSsMASRTSS endocytosis, induced 28591573 2 0 0 glucose uptake -CLDN1 Claudin-1 Cytoskeletal; Membrane protein, integral; Membrane protein, multi-pass O95832 9076 3q28 human T191-p 1869121000 CSCPRKTtSYPTPRP intracellular localization 31398894 1 0 0 regulates Claudin-1 tight junction localization -CTPS1 CTPS EC 6.3.4.2; Ligase; Motility/polarity/chemotaxis; Nucleotide Metabolism - pyrimidine P17812 1503 1p34.2 human S462-p 479852 TLFQTKNsVMRKLYG GATase enzymatic activity, induced cell growth, altered 17463002 1 0 0 -TP53 p53 Activator; DNA-binding; Motility/polarity/chemotaxis; Nuclear receptor co-regulator; Transcription factor; Tumor suppressor P04637 7157 17p13.1 human T150-p 456327 VQLWVDStPPPGTRV P53 protein degradation; molecular association, regulation; ubiquitination cell cycle regulation; cell growth, inhibited; apoptosis, induced; transcription, induced PIN1(INDUCES); FBXO42(INDUCES) DNA(INDUCES) 17906639; 21127074 4 0 8 -Tp53 p53 Activator; DNA-binding; Motility/polarity/chemotaxis; Nuclear receptor co-regulator; Transcription factor; Tumor suppressor P10361 24842 10q24 rat K380-ac 458977 QSTSRHKkPMIKKVG activity, induced; activity, inhibited apoptosis, induced; apoptosis, inhibited 18192848; 35850611 216 10 0 Tolfenamic acid decreased the apoptotic positive cellular rate from 11.91 to 7.47%; tolfenamic acid significantly increased the phosphorylation level of p53 at the Ser378 site andreduced the acetylation level at the Lys382 site site, suggesting that tolfenamic acid may reduce the activity of p53 -EPHA2 EphA2 EC 2.7.10.1; KINASE; Kinase, protein; Membrane protein, integral; Protein kinase, TK; Protein kinase, tyrosine (receptor) P29317 1969 1p36.13 human Y588-p 450859 QLKPLKTyVDPHTYE EphA2_TM activity, induced; molecular association, regulation; enzymatic activity, induced carcinogenesis, induced; cell differentiation, altered; cell motility, induced; cell motility, altered; cell adhesion, altered VAV2(INDUCES); NCK1(INDUCES); VAV3(INDUCES) 18387945; 19193766; 32005975 8 26 649 -CDKN1A p21Cip1 Cell cycle regulation; Inhibitor P38936 1026 6p21.2 human K163-ub 9897004 RLIFSKRkP______ protein degradation; ubiquitination cell cycle regulation; carcinogenesis, induced; cell growth, induced 13678583; 17429006; 28446751 5 0 0 -RNF40 RNF40 EC 6.3.2.-; EC 6.3.2.19; Ligase; UBIQUITIN LIGASE; Ubiquitin conjugating system; Ubiquitin ligase O75150 9810 16p11.2 human S114-p 18710201 ALLRCHEsQGELSSA ubiquitination DNA repair, induced 21362549 1 0 0 induces H2B-K125 ubiquitylation -NEDD1 NEDD1 Cell cycle regulation Q8NHV4 121441 12q23.1 human S460-p 20609205 STSVLHSsPLNVFMG molecular association, regulation; intracellular localization; phosphorylation cell cycle regulation PLK1(INDUCES) 21690413 2 3 0 -MAVS MAVS Adaptor/scaffold; Membrane protein, integral Q7Z434 57506 20p13 human T342-gl 1872691006 AVPSNALtNPAPSKL phosphorylation 31461653 1 1 0 positively regulates phosphorylation of S442 (data from MAVS 7A mutant) -Numb NUMB Cell development/differentiation Q2LC84 29419 6q24 rat S294-p 470030 SPFKRQLsLRINELP NumbF molecular association, regulation AP2A1(DISRUPTS); AP2B1(DISRUPTS); 14-3-3 eta(INDUCES) 17022975 4 9 17 -AMPH amphiphysin Vesicle P49418 273 7p14.1 human T387-p 469997 LPWDLWTtSTDLVQP molecular association, regulation CLTC(DISRUPTS) 16945112 1 0 0 -MIF MIF Amino Acid Metabolism - phenylalanine; Amino Acid Metabolism - tyrosine; Apoptosis; Cell development/differentiation; Cytokine; EC 5.3.2.1; EC 5.3.3.12; Isomerase P14174 4282 22q11.23 human K78-ac 461652 AQNRSYSkLLCGLLA MIF intracellular localization apoptosis, inhibited AIF1(DISRUPTS) 35585040 1 8 22 impaired MIF interaction with AIF and nuclear translocation, protect neuronal death, reduces ischemia-induced brain injury -MYC Myc DNA-binding; Nucleolus; Oncoprotein; Transcription factor P01106 4609 8q24.21 human T263-p 1876391102 HEETPPTtSSDSEEE Myc_N protein degradation; molecular association, regulation; ubiquitination FBXW7(INDUCES) 35089787 1 0 0 -LTB4R LTB4R GPCR, family 1; Membrane protein, integral; Membrane protein, multi-pass; Receptor, GPCR Q15722 1241 14q12 human T308-p 455505 VAKLLEGtGSEASST receptor internalization, induced; receptor desensitization, altered signaling pathway regulation 12077128; 22707565; 30131369 4 2 0 enhanced ligand-induced internalization ; chemotaxis, B-hexisaminidase release, regulates LTB4R function -Foxo1 FOXO1A DNA-binding; Nuclear receptor co-regulator; Oncoprotein; Transcription factor Q9R1E0 56458 3 C|3 23.19 cM mouse S316-p 449113 TFRPRTSsNASTISG intracellular localization transcription, inhibited 10698940 29 5 27 -EIF3H eIF3S3 Translation; Translation initiation O15372 8667 8q23.3-q24.11 human S183-p 471116 VCKEKDFsPEALKKA eIF3h_C activity, induced cell growth, altered 18544531 1 30 2 -TBL1XR1 TBL1XR1 Nuclear receptor co-regulator; Transcription, coactivator/corepressor Q9BZK7 79718 3q26.32 human S204-p 2509600 NLSENSTsGSTQLVL transcription, induced 18374649 1 0 0 -CDK2 CDK2 Cell cycle regulation; EC 2.7.11.22; KINASE; Kinase, protein; Protein kinase, CMGC; Protein kinase, Ser/Thr (non-receptor) P24941 1017 12q13.2 human Y15-p 447740 EKIGEGTyGVVYKAR Pkinase protein stabilization; enzymatic activity, inhibited; protein conformation cell cycle regulation 11298456; 12912980; 13678583; 1396589; 14551212; 15632290; 17095507; 18927589; 23671119; 26240362; 34156324 33 129 3845 -Ppp1r3a PPP1R3A Membrane protein, integral; Protein phosphatase, regulatory subunit Q99MR9 140491 6|6 A1 mouse S67-p 449321 TSASRRVsFADSLGF molecular association, regulation PPA1(DISRUPTS) 24244723 6 1 0 -HSPB8 HSPB8 Heat shock protein Q9UJY1 26353 12q24.23 human S27-p 7994902 PFRDSPLsSRLLDDG protein conformation 21526341 2 1 0 decrease chaperone activity -Scnn1g ENaC-gamma Channel, sodium; Membrane protein, integral; Membrane protein, multi-pass; Transporter, ion channel P37091 24768 1q36 rat K6-ub 486250 __MAPGEkIKAKIKK receptor recycling, inhibited; protein degradation; intracellular localization 9351815 1 0 0 -KDM3A JMJD1A DEMETHYLASE; Demethylase; EC 1.14.11.-; Nuclear receptor co-regulator; Oxidoreductase Q9Y4C1 55818 2p11.2 human S264-p 8100021 IGAVKRKsSENNGTL molecular association, regulation chromatin organization, altered; transcription, induced STAT1(INDUCES) 25535969 2 9 1 -HSF1 HSF1 DNA-binding; Transcription factor Q00613 3297 8q24.3 human K298-ac 31953301 SSPLVRVkEEPPSPP Vert_HS_TF protein stabilization; protein conformation 24581496 1 1 0 -MAPK1 ERK2 EC 2.7.11.24; KINASE; Kinase, protein; Protein kinase, CMGC; Protein kinase, Ser/Thr (non-receptor) P28482 5594 22q11.22 human S246-p 6845001 HILGILGsPSQEDLN Pkinase molecular association, regulation; intracellular localization cell growth, induced IPO7(INDUCES); NUP153(DISRUPTS) 18760948; 21730285 2 1 0 -Adcy6 ADCY6 Adenylyl cyclase; EC 4.6.1.1; Lyase; Membrane protein, integral; Membrane protein, multi-pass; Nucleotide Metabolism - purine; Transporter; Transporter, aquaporin family AAA40678 25289 7q36 rat S750-p 467274 LSRSIVRsRVHSTAV enzymatic activity, induced 11327830; 15470083 2 0 0 increases potentiation -MRE11 MRE11A Cell cycle regulation; DNA repair, damage; DNA-binding; Deoxyribonuclease P49959 4361 11q21 human R570-me 2344812 SAATNKGrGRGRGRR intracellular localization 15970667 1 0 0 localizes in nucleus and associates with nuclear bodies and sites of DNA damage -NTRK1 TrkA iso2 EC 2.7.10.1; KINASE; Kinase, protein; Membrane protein, integral; Oncoprotein; Protein kinase, TK; Protein kinase, tyrosine (receptor) P04629-2 4914 1q23.1 human Y675-p 447764 DIYSTDYyRVGGRTM PK_Tyr_Ser-Thr activity, induced; intracellular localization; enzymatic activity, induced; phosphorylation cell differentiation, induced 27655914; 29229648; 9099755 14 3 6 neurite outgrowth and differentiation -Vasp VASP Cytoskeletal; Motility/polarity/chemotaxis P70460 22323 7|7 A3 mouse S235-p 448380 GAKLRKVsKQEEASG molecular association, regulation; intracellular localization cytoskeletal reorganization; transcription, altered ACTR3B(DISRUPTS); Arp3(DISRUPTS); ACTG1(DISRUPTS); MYO1C(DISRUPTS); Abl iso4(INDUCES); MYO5A(DISRUPTS); ARP2(DISRUPTS); MYO1B(DISRUPTS) 12087107; 33976159; 36350314; 37019383 62 26 3 -Tnnt2 TNNT2 Motility/polarity/chemotaxis; Motor P50752 21956 1 E4|1 59.32 cM mouse T216-p 451556 RKSGKRQtEREKKKK Troponin activity, inhibited 12832403 7 0 0 -WNK4 WNK4 EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, Other; Protein kinase, Ser/Thr (non-receptor) Q96J92 65266 17q21.2 human S1022-p 1871464501 GRFQVTSsKEPAEPL molecular association, regulation; ubiquitination ubiquitin(INDUCES) 33376515 1 0 0 -SQSTM1 SQSTM1 Autophagy; Nuclear receptor co-regulator; Ubiquitin conjugating system Q13501 8878 5q35.3 human K7-ub 55588403 _MASLTVkAYLLGKE activity, induced; protein degradation; molecular association, regulation autophagy, induced SQSTM1(DISRUPTS) 26942676; 35100065 2 0 0 OTUD7B enhances SQSTM1 oligomerzation activity to promote IRF3 degradation; TRIM1 ubiquitylation abrogates oligomerization and sequestering client proteins -Keap1 -IQCB1 IQCB1 Cell development/differentiation Q15051 9657 3q13.33|3q21.1 human K205-ub 15491986 DLLRIGRkALYSILD intracellular localization cell cycle regulation; cytoskeletal reorganization 28498859 1 3 1 regulation of cilia formation -STAT5A STAT5A DNA-binding; Motility/polarity/chemotaxis; Oncoprotein; Transcription factor P42229 6776 17q21.2 human S780-p 448750 DSLDSRLsPPAGLFT molecular association, regulation; intracellular localization carcinogenesis, induced; carcinogenesis, inhibited; cell growth, inhibited; apoptosis, induced; transcription, altered; transcription, inhibited ERK1(DISRUPTS) 10194762; 31932645; 34188118 12 25 0 -Kcnj8 KCNJ8 Channel, potassium; Membrane protein, integral; Membrane protein, multi-pass Q63664 25472 4q44 rat S385-p 483976 NSLRKRNsMRRNNSM activity, induced; activity, inhibited 15087422; 18048350 3 0 0 -CHRM2 mAChR M2 GPCR, family 1; Membrane protein, integral; Membrane protein, multi-pass; Receptor, GPCR P08172 1129 7q33 human T310-p 459108 QDENTVStSLGHSKD 7tm_1 receptor desensitization, altered; receptor internalization, altered 9162044 3 0 0 Mutation of 4 S/T to A eliminates receptor desensitization in response to carbachol treatment (as measured by isoproterenol-stimulated cAMP production after pretreatment with carbachol).; Mutation of S286 T287 S288 S290 to A caused a faster rate and a greater extent of receptor internalization after agonist stimulation (transients only, not observed in stables). Mutation of all 8 sites prevented internalization (in both transients and stables). -GCM1 GCM1 DNA-binding; Transcription factor Q9NP62 8521 6p12.1 human S47-p 20745200 YAKHIYSsEDKNAQR GCM sumoylation; molecular association, regulation transcription, induced SENP1(INDUCES) 21791615 1 1 0 induces GCM1 desumoylation, Epac regulates placental cell fusion via GCM1 -MAPK3 ERK1 EC 2.7.11.24; KINASE; Kinase, protein; Protein kinase, CMGC; Protein kinase, Ser/Thr (non-receptor) P27361 5595 16p11.2 human T202-p 447542 HDHTGFLtEYVATRW Pkinase activity, induced; protein degradation; molecular association, regulation; intracellular localization; protein conformation; phosphorylation; enzymatic activity, induced cell cycle regulation; carcinogenesis, induced; apoptosis, altered; apoptosis, induced; cell motility, induced; cell motility, inhibited; signaling pathway regulation; cell growth, induced; cell motility, altered; transcription, inhibited; cell growth, altered; cell differentiation, inhibited; carcinogenesis, inhibited; cell growth, inhibited; transcription, induced; transcription, altered; autophagy, induced; cell differentiation, induced; apoptosis, inhibited; autophagy, inhibited; cytoskeletal reorganization TACE(INDUCES); leupaxin(NOT_REPORTED); GSK3B(INDUCES); KSR(INDUCES) 10597231; 10925301; 11352917; 12368275; 12609989; 12808105; 12917346; 12952943; 15004239; 16149052; 16397900; 16585161; 17562849; 17667937; 17685427; 18042541; 18045996; 18519681; 18658095; 18775330; 19088846; 19106095; 19144315; 20122898; 20228268; 20231899; 20868520; 21478863; 21530327; 21561860; 21685939; 21726627; 21730054; 21893193; 21917714; 21980390; 22385658; 23644655; 24632852; 25538243; 26073130; 26079947; 26586479; 27323830; 28574827; 30987999; 31722981; 31736979; 31933886; 32081857; 32107290; 33627405; 33667549; 33731431; 33820494; 33828192; 34017102; 34209868; 34226680; 34262144; 34380633; 34473994; 34480897; 34497368; 34588619; 34611296; 34611309; 34642304; 34675408; 34743207; 34921013; 34992144; 35173310; 35293964; 35367211; 35414784; 35439648; 35544764; 36053753; 36216931; 36289618; 36346366; 36455198; 36509141; 36529291; 36966223; 37016335; 7535768; 8444886 1343 110 2017 -ITGA2 ITGA2 Cell adhesion; Membrane protein, integral; Motility/polarity/chemotaxis; Receptor, misc. P17301 3673 5q11.2 human S1180-p 3181118 IDETTELsS______ molecular association, regulation MST1(INDUCES) 27765911 1 4 0 -Tbx2 TBX2 DNA-binding; Transcription factor Q60707 21385 11 C|11 51.34 cM mouse S623-p 1308917 ARPRLRFsPYQIPVT activity, induced; protein stabilization; intracellular localization transcription, inhibited 18025091 1 0 0 relocalizes into nuclei after UV radiation -Snap25 SNAP-25 Vesicle P60879 20614 2 F3|2 67.56 cM mouse S187-p 448668 RIMEKADsNKTRIDE activity, inhibited neural plasticity; exocytosis, altered 12417653; 18162553; 28801590; 35309682 15 1 0 -Myb Myb DNA-binding; Oncoprotein; Transcription factor P06876 17863 10 A3|10 9.75 cM mouse T572-p 1308922 LTSSVLMtPVSEDED protein degradation; ubiquitination cell differentiation, induced; transcription, induced 18006338; 19421138; 21092141; 32873855 4 0 0 induces transcription of itself to compensate for post translational modifications -Cacnb2 CACNB2 Channel, calcium Q8VGC3 116600 17q12.3 rat S530-p 451474 KSQHRSSsATHQNHR activity, induced 10567342 4 1 0 -Shc1 SHC1 Adaptor/scaffold; Apoptosis; Mitochondrial; Motility/polarity/chemotaxis P98083 20416 3 F1|3 39.11 cM mouse K81-ac 63115300 AGGRLGPkGEPGKAA intracellular localization; phosphorylation 28137876 1 1 0 induces phosphorylation at S36 -PPM1B PPM1B EC 3.1.3.16; Motility/polarity/chemotaxis; PHOSPHATASE; Protein phosphatase, Ser/Thr (non-receptor) O75688 5495 2p21 human S195-p 27461503 MIQRVNGsLAVSRAL PP2C protein degradation; ubiquitination 23756813 1 4 0 inhibition of anti-inflammatory response -PIK3R1 PIK3R1 KINASE; Kinase, lipid; Motility/polarity/chemotaxis P23727 282307 cow Y688-p 448137 FAEPYNLySSLKELV SH2 molecular association, regulation PIK3R1(INDUCES) 11337495 3 0 0 phosphorylation of this site increases activity of PI3K lipid kinase and modulates transcription through NFkB -MAPK7 ERK5 EC 2.7.11.24; KINASE; Kinase, protein; Protein kinase, CMGC; Protein kinase, Ser/Thr (non-receptor) Q13164 5598 17p11.2 human K6-sm 2887213 __MAEPLkEEDGEDG molecular association, regulation; intracellular localization cell growth, induced; transcription, induced HSP90A(DISRUPTS) 32209980 4 0 0 nuclear translocation; Hsp90 dissociation from the ERK5-Cdc37 complex -Cdkn1b p27Kip1 Cell cycle regulation; Inhibitor; Oncoprotein; Protein kinase, regulatory subunit P46414 12576 6 G1|6 65.77 cM mouse S175-p 28058801 NRTEENVsDGSPNAG phosphorylation 23602409 1 3 0 induces phosphorylation at T183 -ASXL2 ASXL2 DNA-binding Q76L83 55252 2p23.3 human R641-m2 27269954 SQVSPRArFPVSITS cell differentiation, inhibited; apoptosis, inhibited; transcription, inhibited MLL3(DISRUPTS) DNA(DISRUPTS) 36197977 1 2 8 CARM1 inhibition up-regulates apoptosis and differentiation related genes -RECQL4 RECQL4 EC 3.6.4.12; Helicase O94761 9401 8q24.3 human S89-p 25173042 LNRAATKsPQSTPGR Drc1-Sld2 molecular association, regulation; ubiquitination; intracellular localization DNA repair, induced WDHD1(INDUCES); DDB1(INDUCES); MRE11A(INDUCES); GINS4(INDUCES) 29229926; 31519754 2 6 0 enhances the helicase activity; DNA end resection and HR ; induces activation of replication origin; promotes its ubiquitination by DDB1-CUL4A E3 ubiquitin ligase; recruitment to DSBs -ELK1 ELK1 DNA-binding; Transcription factor P19419 2002 Xp11.23 human K230-sm 3982502 PPEAPNLkSEELNVE sumoylation; intracellular localization cell differentiation, inhibited; transcription, induced; transcription, inhibited 14992729; 15210726; 17036045; 30789974 6 2 0 Both ELK1 and ELK-3R promote transcription, K230R, K249R, K254R does not prevent ELK1 SUMOylation, ELK1 and ELK1-3R show same intracellular localization -BCAR1 P130Cas Adaptor/scaffold; Motility/polarity/chemotaxis P56945 9564 16q23.1 human Y234-p 449639 AQPEQDEyDIPRHLL cell growth, induced 26867768 3 31 698 metastases -CFTR CFTR Channel, chloride; EC 3.6.3.49; Hydrolase; Membrane protein, integral; Membrane protein, multi-pass; Transporter; Transporter, ABC family P13569 1080 7q31.2 human S1045-p 56689900 QQLKQLEsEGRSPIF ABC_membrane activity, induced; ubiquitination; receptor internalization, altered 27261451 1 0 0 S1045Y-CFTR exhibits a 50% reduction in channel function, accelerated internalization, docking of E3 ubiquitin ligase c-cbl -CLDN6 Claudin-6 Cell adhesion; Membrane protein, integral; Membrane protein, multi-pass P56747 9074 16p13.3 human Y196-p 7792482 GSQGPSHyMARYSTS cell adhesion, altered; signaling pathway regulation 31740618 1 0 17 -Ugcg UGCG EC 2.4.1.80; Lipid Metabolism - sphingolipid; Membrane protein, integral; Membrane protein, multi-pass; Transferase O88693 22234 4 32.44 cM|4 B3 mouse Y132-p 26420454 INNLMPAyEVAKYDL Glyco_transf_21 enzymatic activity, induced 32980536 1 0 1 regulation of cytotoxicity to ceramide -Runx1 AML1 DNA-binding; Oncoprotein; Transcription factor Q03347 12394 16 C4|16 53.7 cM mouse Y378-p 51211402 GSPSYHLyYGASAGS RunxI activity, induced; protein stabilization transcription, induced HDAC1(DISRUPTS) DNA(INDUCES) 26598521 1 0 0 -YAP1 YAP1 iso2 Oncoprotein; Transcription, coactivator/corepressor P46937-2 10413 11q22.1 human S61-p 484116 IVHVRGDsETDLEAL activity, inhibited cell differentiation, induced; cell growth, inhibited; transcription, inhibited 23027127; 23752589 13 47 1 -BARD1 BARD1 EC 6.3.2.-; EC 6.3.2.19; Ligase; UBIQUITIN LIGASE; Ubiquitin conjugating system; Ubiquitin ligase Q99728 580 2q35 human S184-p 455771 QDSYEFVsPSPPADV cell cycle regulation 15855157 1 4 0 resistance to genotoxic stress (mitomycin C) -INPP5D SHIP iso2 EC 3.1.3.86; Motility/polarity/chemotaxis; Phosphatase, lipid Q92835-2 3635 2q37.1 human Y864-p 454794 GKTREKLyDFVKTER intracellular localization 29852247 1 25 364 nucleocytoplasmic shuttling (A mutants show accumulation in nucleus) -XRCC6 Ku70 DNA repair, damage; DNA-binding; EC 3.6.4.-; EC 4.2.99.-; Helicase; Nuclear receptor co-regulator; RNA-binding P12956 2547 22q13.2 human K570-m3 1883494505 ELKTHISkGTLGKFT intracellular localization apoptosis, inhibited 35545041 1 0 0 enriched in cytoplasm, the methylation of KU70-K570 is a prerequisite for the acetylation of KU70 -Calm1 Calmodulin Calcium-binding; Protein phosphatase, regulatory subunit P0DP29 24242 6q32 rat S82-p 448705 RKMKDTDsEEEIREA molecular association, regulation; activity, inhibited; phosphorylation KCNQ4(INDUCES) 14736917; 24627475; 8206911 9 16 0 T80 site is key to binding. CAM phosphorylation regulates channel trafficking and stabilizes activity-thereby regulating neuronal excitability.; Calmodulin phosphorylated by CKII in vitro showed reduced activation of erythrocyte plasma membrane Ca2+ pump. -EEF2K EEF2K EC 2.7.11.20; KINASE; Kinase, protein; Protein kinase, Ser/Thr (non-receptor); Protein kinase, atypical; Translation O00418 29904 16p12.2 human S445-p 483529 SGDSGYPsEKRGELD protein degradation; molecular association, regulation; ubiquitination carcinogenesis, inhibited; cell growth, inhibited; translation, induced; translation, inhibited BTRC(INDUCES); BRD8(INDUCES) 22669845; 25670349; 35513296 5 29 8 -EHHADH EHHADH Amino Acid Metabolism - lysine degradation; Amino Acid Metabolism - tryptophan; Amino Acid Metabolism - valine, leucine and isoleucine degradation; Carbohydrate Metabolism - butanoate; Carbohydrate Metabolism - propanoate; EC 1.1.1.35; EC 4.2.1.17; EC 5.3.3.8; Isomerase; Lipid Metabolism - fatty acid; Lyase; Mitochondrial; Other Amino Acids Metabolism - beta-alanine; Oxidoreductase; Secondary Metabolites Metabolism - limonene and pinene degradation Q08426 1962 3q27.2 human K346-ac 461836 MITSVLEkEASKMQQ 3HCDH_N enzymatic activity, induced 20167786 0 5 3 -PINK1 PINK1 EC 2.7.11.1; KINASE; Kinase, protein; Membrane protein, integral; Mitochondrial; Protein kinase, Other; Protein kinase, Ser/Thr (non-receptor) Q9BXM7 65018 1p36.12 human S495-p 396518801 ALLQREAsKRPSARV Pkinase autophagy, induced 29284690 1 1 0 mitochondrial autophagy (mitophagy) -IRF2 IRF2 DNA-binding; Transcription factor P14316 3660 4q35.1 human K293-sm 3173814 PDLQVTIkEESNPVP transcription, inhibited 18514056 1 0 0 -FRS2 FRS2 Adaptor/scaffold Q8WU20 10818 12q15 human Y436-p 448154 LEHRQLNyIQVDLEG molecular association, regulation cell differentiation, induced; signaling pathway regulation SHP-2(INDUCES) 11278583; 36410439 6 1 0 activates FGFR1 signaling -ELK4 ELK4 DNA-binding; Transcription, coactivator/corepressor P28324 2005 1q32.1 human S381-p 4317600 IHFWSTLsPVAPLSP transcription, induced 9130707 2 0 0 -Ikbkb IKKB EC 2.7.11.10; KINASE; Kinase, protein; Protein kinase, Other; Protein kinase, Ser/Thr (non-receptor) O88351 16150 8|8 A2 mouse S682-p 17934901 SMNVSRLsHPGQLMS molecular association, regulation; phosphorylation PPP2R3C(INDUCES) 20925653 1 1 0 interaction with PPP2R3C (aka G4-1) downregulates IKK-beta activity; S181 phosphorylation increased in S679/682/689/692/697/701/705A mutant -XRCC6 Ku70 DNA repair, damage; DNA-binding; EC 3.6.4.-; EC 4.2.99.-; Helicase; Nuclear receptor co-regulator; RNA-binding P12956 2547 22q13.2 human K338-ac 458920 KEETEELkRFDDPGL Ku molecular association, regulation DNA repair, inhibited DNA(DISRUPTS) 17545612 3 4 1 -LLGL1 LLGL1 Cell adhesion; Cytoskeletal; Motility/polarity/chemotaxis Q15334 3996 17p11.2 human S670-p 10405473 SFRRIRKsRVSGKKR intracellular localization 34717957 1 0 1 -INVS INVS Q9Y283 27130 9q31.1 human S865-p 55578721 GARRLETsTLSEDFQ cytoskeletal reorganization 27220846 1 0 0 Akt2 plays a more prominent role in ciliary development than Akt1, tubular differentiation -Pld2 PLD2 EC 3.1.4.4; Lipid Metabolism - ether lipid; Lipid Metabolism - glycerophospholipid; Motility/polarity/chemotaxis; Phospholipase P97813 18806 11 B3|11 42.99 cM mouse Y11-p 450938 TQKNLFPyGDYLNSS molecular association, regulation; intracellular localization; phosphorylation; enzymatic activity, induced EGFR(NOT_REPORTED) 15282299; 9837959 2 0 1 -TH TH iso2 Amino Acid Metabolism - tyrosine; EC 1.14.16.2; Endoplasmic reticulum; Mitochondrial; Oxidoreductase; Vesicle P07101-2 7054 11p15.5 human S67-p 448545 RFIGRRQsLIEDARK TOH_N enzymatic activity, induced 7901013 62 11 11 -RBM17 RBM17 RNA splicing; RNA-binding; Spliceosome Q96I25 84991 10p15.1 human S48-p 27936101 KSQRTKQsTVLAPVI molecular association, regulation; phosphorylation RNA splicing, inhibited; cell motility, induced RNA(DISRUPTS) 23519612 1 0 0 induced cell invasion, enhanced Cortactin phosphorylation at ERK-dependent sites -PTH1R PTHR GPCR, family 2; Membrane protein, integral; Membrane protein, multi-pass; Receptor, GPCR Q03431 5745 3p21.31 human S491-p 452061 KRKARSGsSSYSYGP receptor internalization, induced; molecular association, regulation ARR3(INDUCES) 27623777 5 4 0 S503 AND T504 IN THE SECOND CLUSTER ARE RESPONSIBLE FOR 70% OF ARRESTIN3 RECRUITMENT -H3c1 H3 DNA-binding P68433 360198 13|13 A3.1 mouse S28-p 455677 ATKAARKsAPATGGV Histone molecular association, regulation chromatin organization, altered; transcription, induced; transcription, altered; cell growth, altered 14-3-3 zeta(INDUCES); 14-3-3 epsilon(INDUCES) DNA(INDUCES) 18381464; 20129940; 21460852 50 18 0 increases occupancy of Brf1 and TBP promoters -Ets1 Ets-1 DNA-binding; Motility/polarity/chemotaxis; Oncoprotein; Transcription factor P27577 23871 9 A4|9 17.97 cM mouse K15-sm 3656301 KPTLTIIkTEKVDLE transcription, inhibited 16729975; 16862185 3 1 0 -SNCA SNCA Adaptor/scaffold P37840 6622 4q22.1 human Y133-p 448280 EMPSEEGyQDYEPEA molecular association, regulation SNCA(DISRUPTS) 36690898 3 0 0 -Cnp CNP Cell development/differentiation; EC 3.1.4.37; Phosphodiesterase P13233 25275 10q31 rat K196-ac 1881330703 FGWFLTKkSSETLRK enzymatic activity, inhibited; protein conformation 34330062 1 1 0 -FLCN FLCN Tumor suppressor Q8NFG4 201163 17p11.2 human S542-p 23107127 LLSILGAsEEDNVKL Folliculin_C molecular association, regulation FNIP2(INDUCES); LC3B(DISRUPTS); GABARAP(DISRUPTS) 25126726 1 1 1 -SENP1 SENP1 DESUMOYLASE; EC 3.4.22.68; Nuclear receptor co-regulator; Protease; Sumo-specific protease Q9P0U3 29843 12q13.11 human Y270-p 1876335002 EQLSHSVySLSSYTP sumoylation; molecular association, regulation; enzymatic activity, inhibited SUMO1(INDUCES); SUMO3(INDUCES) 35186948 1 0 0 alters substrate desumoylation -ROCK2 ROCK2 EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, AGC; Protein kinase, Ser/Thr (non-receptor) Q28021 282041 cow T967-p 1732201 ELTEKDAtIASLEET enzymatic activity, induced cell cycle regulation 17446864 1 0 0 alanine mutation of all 4 sites -XRCC4 XRCC4 DNA repair, damage Q13426 7518 5q14.2 human S260-p 475982 KDDSIISsLDVTDIA XRCC4 DNA repair, induced 30247612 4 4 1 induces cell survival -NR1H3 LXR-alpha DNA-binding; Motility/polarity/chemotaxis; Nuclear receptor Q13133 10062 11p11.2 human K328-sm 12004412 YNREDFAkAGLQVEF Hormone_recep molecular association, regulation transcription, inhibited DNA(INDUCES) 17218271 2 0 0 -CCDC88C Daple Inhibitor Q9P219 440193 14q32.11-q32.12 human Y2025-p 899136400 PQTVWYEyGCV____ molecular association, regulation DVL1(DISRUPTS) 29487190 1 1 0 -PCYT1A PCYT1A EC 2.7.7.15; Lipid Metabolism - glycerophospholipid; Transferase P49585 5130 3q29 human S315-p 451321 GRMLQAIsPKQSPSS intracellular localization 32186954 4 67 13 -ARID4B ARID4B DNA-binding Q4LE39 51742 1q42.3 human K440-sm 12004426 ETEIKEIkMEEERNI cell cycle regulation; cell growth, inhibited; transcription, inhibited 16479010 1 1 0 -Ikbkg IKKG Adaptor/scaffold; Protein kinase, regulatory subunit O88522 16151 X|X A7.3 mouse S85-p 458399 ELLHFQVsQREEKEF NEMO activity, induced signaling pathway regulation 20932476 5 0 0 IKK activation, leading to TAK1 activation -TAOK1 TAO1 EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, STE; Protein kinase, Ser/Thr (non-receptor) Q7L7X3 57551 17q11.2 human T502-p 3627514 RLDKDLEtQRNNFAA activity, induced cell cycle regulation 17396146 1 0 0 -NBN NBS1 Cell cycle regulation; DNA repair, damage O60934 4683 8q21.3 human K441-ac 487510 TKLPSINkSKDRASQ phosphorylation cell cycle regulation; apoptosis, induced 17612497 2 1 0 inhibits phosphorylation at S343 -Clk2 CLK2 EC 2.7.12.1; KINASE; Kinase, protein; Protein kinase, CMGC; Protein kinase, dual-specificity (non-receptor) O35491 12748 3|3 F1 mouse Y99-p 26375902 DTDFRQSyEYHRENS protein degradation 20074525 1 0 0 -LRRK2 LRRK2 EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, Ser/Thr (non-receptor); Protein kinase, TKL Q5S007 120892 12q12 human T2035-p 477192 GIKTSEGtPGFRAPE Pkinase enzymatic activity, induced 20595391 5 1 0 -KHDRBS1 KHDRBS1 RNA-binding Q07666 10657 1p35.2 human R304-m2 476770 PPPVPRGrGVGPPRG intracellular localization 12529443 1 3 7 -MYC Myc DNA-binding; Nucleolus; Oncoprotein; Transcription factor P01106 4609 8q24.21 human K332-sm 40724412 AAPPSTRkDYPAAKR Myc_N protein degradation; ubiquitination transcription, inhibited 25895136 1 1 0 -SH2D1B SH2D1B Adaptor/scaffold O14796 117157 1q23.3 human Y127-p 4140135 FVNSNSDyVDVLP__ molecular association, regulation exocytosis, induced; cytoskeletal reorganization PLCG1(INDUCES); PLCG2(INDUCES) 24642916; 24687958 2 0 8 activating function of CD244 required the C-terminal tyrosine Y127, SH2D18 promoted MTOC and granule polarization and exocytosis -Lpcat2 AYTL1 ACETYLTRANSFERASE; Acetyltransferase; EC 2.3.1.23; EC 2.3.1.51; EC 2.3.1.67; Membrane protein, integral Q8BYI6 270084 8|8 C5 mouse S34-p 15146101 PMVPRQAsFFPPPVP enzymatic activity, induced 20663880; 24742674 2 3 0 increases biosynthesis of platelet-activating factor (PAF) -Mapk7 ERK5 EC 2.7.11.24; KINASE; Kinase, protein; Protein kinase, CMGC; Protein kinase, Ser/Thr (non-receptor) Q9WVS8 23939 11|11 B2 mouse S766-p 14561005 DSASLSAsLLADWLE transcription, altered 17928297 1 1 0 -Apbb1ip RIAM Adaptor/scaffold; Motility/polarity/chemotaxis Q8R5A3 54519 2|2 A3 mouse Y427-p 1871479101 AKYGKTLyDNYQRAV activity, induced; intracellular localization cell adhesion, induced; signaling pathway regulation 33275877 1 0 0 induces integrin activation/ integrin signaling pathway -Cdk1 CDK1 Cell cycle regulation; EC 2.7.11.22; EC 2.7.11.23; KINASE; Kinase, protein; Motility/polarity/chemotaxis; Protein kinase, CMGC; Protein kinase, Ser/Thr (non-receptor) P39951 54237 20p11 rat T161-p 447609 GIPIRVYtHEVVTLW Pkinase cell cycle regulation 36125973 44 43 83 -H2AZ1 H2AZ DNA-binding P0C0S5 3015 4q23 human K15-ub 12255514 DSGKAKTkAVSRSQR Histone intracellular localization DNA repair, induced 32424115 1 0 5 recruiting downstream DNA repair proteins to DNA breaks -KAT8 MYST1 ACETYLTRANSFERASE; Acetyltransferase; EC 2.3.1.48 Q9H7Z6 84148 16p11.2 human T392-p 34424910 LSQMTSItQNDIIST MOZ_SAS molecular association, regulation; intracellular localization DNA repair, induced; apoptosis, inhibited 53BP1(DISRUPTS) 24953651 1 0 0 DNA DSB repair by HR pathway, enhanced chromatin retention of MOF -Ciz1 CIZ1 Cell cycle regulation Q8VEH2 68379 2|2 B mouse T191-p 22648006 QARTPSStTPNRKDS activity, inhibited cell cycle regulation 15585571 1 0 0 DNA replication -NOS3 eNOS Amino Acid Metabolism - arginine and proline; EC 1.14.13.39; Oxidoreductase P29473 287024 cow S635-p 448637 WRRKRKEsSNTDSAG Flavodoxin_1 acetylation; phosphorylation; enzymatic activity, induced 12171920; 12591925; 16257964; 20479254 28 12 7 -HNF4A HNF4 alpha DNA-binding; Nuclear receptor; Transcription factor P41235 3172 20q13.12 human S143-p 458369 RISTRRSsYEDSSLP molecular association, regulation transcription, inhibited; signaling pathway regulation DNA(DISRUPTS) 21598922 4 3 12 PKA signaling pathway -Map3k14 Nik EC 2.7.11.25; KINASE; Kinase, protein; Protein kinase, STE; Protein kinase, Ser/Thr (non-receptor) Q9WUL6 53859 11 E1|11 66.8 cM mouse S862-p 27259003 GVKVQIQsLNGEHLH protein degradation 23023393 1 1 0 -MVB12A FAM125A Adaptor/scaffold Q96EY5 93343 19p13.11 human S170-p 3208938 SRDMQGLsLDAASQP DUF2464 protein processing 18005716 1 42 0 inhibition of HIV-1 release and infectivity -RAPH1 RAPH1 Adaptor/scaffold; Motility/polarity/chemotaxis Q70E73 65059 2q33.2 human Y466-p 457365 KYKAPTDyCLVLKHP PH molecular association, regulation cell motility, induced 26996666 1 0 3 Lpd-Scar/WAVE interaction is positively regulated by c-Abl and c-Src, breast cancer cell invasion -PAX3 PAX3 DNA-binding; Oncoprotein; Transcription factor P23760 5077 2q36.1 human S205-p 4145506 APQSDEGsDIDSEPD cell growth, inhibited 25821947 6 1 0 -DRD1 DRD1 GPCR, family 1; Membrane protein, integral; Membrane protein, multi-pass; Receptor, GPCR P21728 1812 5q35.2 human S431-p 458340 LDYDTDVsLEKIQPI molecular association, regulation signaling pathway regulation G-alpha(s)(INDUCES); ARR3(INDUCES) 32503917 2 0 0 ERK1/2 activation -IRF1 IRF1 Transcription factor; Tumor suppressor P10914 3659 5q31.1 human K275-sm 2134718 VYGDFSCkEEPEIDS protein stabilization; ubiquitination carcinogenesis, induced; apoptosis, inhibited; transcription, inhibited 17942705 1 0 0 inhibits ubiquitination -Crtc3 TORC3 Transcription, coactivator/corepressor Q91X84 70461 7|7 D3 mouse S329-p 468980 SGLQSSRsNPSIQAT molecular association, regulation transcription, inhibited 14-3-3 beta(INDUCES) 23033494 1 41 16 inhibits nuclear localization -Slc12a5 KCC2 Membrane protein, integral; Membrane protein, multi-pass; Transporter; Transporter, SLC family Q63633 171373 3q42 rat Y926-p 14932400 SDISAYTyEKTLVME SLC12 protein degradation 20600929 1 0 0 decreases the cell surface stability of SLC12A5 (aka KCC2) -RPL23A RPL23A Ribosomal; Translation P62750 6147 17q11.2 human K78-ub 22251150 LDHYAIIkFPLTTES Ribosomal_L23 protein degradation; ubiquitination transcription, altered 35637966 1 4 0 HERC3 could control protein expression and ubiquitination of c-Myc/p21 via RPL23A -Plk4 PLK4 EC 2.7.11.21; KINASE; Kinase, protein; Nucleolus; Protein kinase, Other; Protein kinase, Ser/Thr (non-receptor) Q64702 20873 3|3 B mouse S301-p 12654009 ITASSGTsLSGSLLD protein degradation; ubiquitination 20100909 2 1 0 -Nr4a1 Nur77 Apoptosis; DNA-binding; Nuclear receptor P12813 15370 15|15 F1 mouse K539-ub 1869841400 NRIASCLkEHMATVA Hormone_recep protein degradation 30224829; 33087562 2 0 0 -CDC25A CDC25A EC 3.1.3.48; Motility/polarity/chemotaxis; PHOSPHATASE; Protein phosphatase, dual-specificity P30304 993 3p21.31 human T80-p 4209300 RMGSSEStDSGFCLD protein degradation; molecular association, regulation; ubiquitination; phosphorylation GSK3B(INDUCES) 18167338 2 0 0 -Sod2 SOD2 EC 1.15.1.1; Mitochondrial; Oxidoreductase P09671 20656 17 A1|17 8.75 cM mouse K122-ac 475813 GELLEAIkRDFGSFE Sod_Fe_C intracellular localization; protein conformation; enzymatic activity, induced 28433661; 32606301 9 6 68 mediates pentameric SOD2 deaggregation; importation into mitochondria; in HFD WT Lipid peroxidation increased, but was attenuated in BLOC1S1-/- HFD mice -Gsk3b GSK3B EC 2.7.11.1; EC 2.7.11.26; KINASE; Kinase, protein; Protein kinase, CMGC; Protein kinase, Ser/Thr (non-receptor) Q9WV60 56637 16|16 B3 mouse S389-p 454221 ARIQAAAsPPANATA intracellular localization; enzymatic activity, inhibited; phosphorylation transcription, induced; signaling pathway regulation 18451303; 25477508; 26822034; 34948382 6 13 0 inhibits mTOR complex 1 signaling, primes phosphorylation at S9 and inhibits phosphorylation of p70S6K, enhances cardiomyocyte survival and protects from cardiomyocyte hypertrophy; NFAT transcription induced; nuclear GSK3B, V(D)J recombination -UBE2I UBC9 EC 6.3.2.-; EC 6.3.2.19; Ligase; Nuclear receptor co-regulator; SUMO LIGASE; SUMO conjugating system; SUMO ligase; UBIQUITIN LIGASE; Ubiquitin conjugating system; Ubiquitin ligase P63279 7329 16p13.3 human K153-sm 2344804 KRVRAQAkKFAPS__ sumoylation; molecular association, regulation RASD2(INDUCES) 20424159 2 3 0 RASD2 enhances sumoylation, induces sumoylation of SP100 -MAPRE1 EB1 Cytoskeletal; Motility/polarity/chemotaxis Q15691 22919 20q11.21 human T206-p 59049802 QVNVLKLtVEDLEKE molecular association, regulation; protein conformation cytoskeletal reorganization Restin(INDUCES); dynactin 1(INDUCES); TUBB(INDUCES) 27721984; 28039481 3 1 0 astral microtubule stability ; regulating astral microtubule stability and spindle orientation/positioning -DGKD DGKD EC 2.7.1.107; Kinase, lipid; Lipid Metabolism - glycerolipid; Lipid Metabolism - glycerophospholipid; Motility/polarity/chemotaxis Q16760 8527 2q37.1 human S70-p 452138 QNNSFQRsKRRYFKL PH intracellular localization 15228384 1 0 0 Phosphorylation appears to disrupt translocation of DAGK to the plasma membrane. -CLCN1 CLCN1 Channel, chloride; Membrane protein, integral; Membrane protein, multi-pass; Transporter; Transporter, ion channel P35523 1180 7q34 human S892-p 14645302 ASFRNTTsTRKSTGA activity, induced 20511714 1 0 1 -STAT5A STAT5A DNA-binding; Motility/polarity/chemotaxis; Oncoprotein; Transcription factor P42231 443419 sheep Y694-p 447767 LAKAVDGyVKPQIKQ activity, induced transcription, altered 7925280 156 50 2180 -WAC WAC Adaptor/scaffold Q9BTA9 51322 10p12.1|10p12.1-p11.2 human T471-p 469445 PIKPLIStPPVSSQP molecular association, regulation; phosphorylation cell cycle regulation PLK1(INDUCES) 30021153 1 9 31 -Brsk2 BRSK2 EC 2.7.11.1; EC 2.7.11.26; KINASE; Kinase, protein; Protein kinase, CAMK; Protein kinase, Ser/Thr (non-receptor) Q69Z98 75770 7|7 F5 mouse S456-p 4734903 PVHTPKEsPAGTPNP protein stabilization; enzymatic activity, inhibited; phosphorylation 23790753 1 3 0 inhibits axon branching (activated in BRSK2 18A mutant) -CDH2 CDH2 Cell adhesion; Membrane protein, integral; Motility/polarity/chemotaxis P19022 1000 18q12.1 human Y860-p 458305 DSLLVFDyEGSGSTA CADH_Y-type_LIR molecular association, regulation CTNNB1(DISRUPTS) 16371504 2 0 0 -SIK3 QSK EC 2.7.11.1; KINASE; Kinase, protein; Motility/polarity/chemotaxis; Protein kinase, CAMK; Protein kinase, Ser/Thr (non-receptor) Q9Y2K2 23387 11q23.3 human T221-p 456036 TPGQLLKtWCGSPPY Pkinase protein stabilization; molecular association, regulation; phosphorylation; enzymatic activity, induced 14-3-3 beta(INDUCES) 22588126; 35413286; 37477881 8 17 14 -Elk1 ELK1 DNA-binding; Transcription factor P41969 13712 X A1.3|X 16.45 cM mouse T364-p 22725902 LLPTHTLtPVLLTPS molecular association, regulation transcription, induced MED16(INDUCES); MED23(INDUCES); Trap100(INDUCES) 27738173 2 0 0 -Spag5 SPAG5 Cell cycle regulation Q7TME2 54141 11 B5|11 46.74 cM mouse S447-p 11270700 SSTQTDSsPCGVTKT cell cycle regulation 19806032 1 0 0 T24/66/447A mutant impairs meiosis progression -Trpm3 TRPM3 Channel, cation; Membrane protein, integral; Membrane protein, multi-pass Q5F4S9 226025 19|19 B mouse S1184-p 1875848400 CRWRKHEsDQDERDY activity, inhibited 34884938 1 0 0 -MYC Myc DNA-binding; Nucleolus; Oncoprotein; Transcription factor P01106 4609 8q24.21 human R361-me 1873076614 NRKCTSPrSSDTEEN molecular association, regulation transcription, induced p300(INDUCES); MAX(INDUCES) 28652407 1 1 0 proximity ligation assay (PLA) -TRIM28 TIF1B EC 6.3.2.-; KINASE; Kinase, protein; Ligase; Nuclear receptor co-regulator; Protein kinase, atypical; SUMO LIGASE; SUMO ligase; Transcription, coactivator/corepressor; UBIQUITIN LIGASE; Ubiquitin conjugating system; Ubiquitin ligase Q13263 10155 19q13.43 human S824-p 460839 LPGAGLSsQELSGGP activity, induced; sumoylation; molecular association, regulation; intracellular localization; phosphorylation cell cycle regulation; carcinogenesis, induced; carcinogenesis, inhibited; cell growth, inhibited; apoptosis, induced; transcription, induced; signaling pathway regulation; DNA repair, induced; translation, altered; chromatin organization, altered; apoptosis, inhibited; transcription, inhibited POLH(INDUCES); CHD-1(DISRUPTS); TRIM24(DISRUPTS) DNA(INDUCES) 16862143; 17942393; 20424263; 21642969; 21765463; 22205726; 22491012; 23645696; 25355892; 26212333; 28607002; 32060145; 32061892; 32156811; 34194047; 34518220; 34676045; 35339488; 37438603 47 9 6 -Dlg1 DLG1 Adaptor/scaffold; Motility/polarity/chemotaxis Q62696 25252 11q22 rat S158-p 2024309 FVSHSHIsPIKPTEA MAGUK_N_PEST molecular association, regulation; intracellular localization cytoskeletal reorganization GKAP1(DISRUPTS) 15729360 4 16 0 -Acss1 ACSS1 Carbohydrate Metabolism - glycolysis and gluconeogenesis; Carbohydrate Metabolism - propanoate; Carbohydrate Metabolism - pyruvate; EC 6.2.1.1; Ligase; Mitochondrial Q99NB1 68738 2|2 G3 mouse K635-ac 464663 LPKTRSGkVMRRLLR AMP-binding_C enzymatic activity, inhibited 16790548 2 2 0 -SLC6A3 DAT Membrane protein, integral; Membrane protein, multi-pass; Transporter; Transporter, SLC family Q01959 6531 5p15.33 human S7-p 451136 _MSKSKCsVGLMSSV activity, induced; molecular association, regulation; protein conformation Other(INDUCES) 15024426; 16908408; 23161550 6 1 1 increases DAT affinity for cocaine analog binding; stimulates DAT-mediated efflux of dopamine -Plekhf1 PKHF1 Q3TB82 72287 7|7 B3 mouse Y268-p 1868624701 WPTQVEFyASGVSWS molecular association, regulation endocytosis, induced; signaling pathway regulation caveolin-1(INDUCES) 31189603 1 0 0 endocytosis of bacteria -Ppp3ca PPP3CA EC 3.1.3.16; PHOSPHATASE; Protein phosphatase, Ser/Thr (non-receptor) P63329 24674 2q43 rat S411-p 2048309 GKMARVFsVLREESE intracellular localization; phosphorylation apoptosis, induced; signaling pathway regulation 19608982 1 4 1 inhibits phosphorylation and nuclear translocation of NFAT, regulates Calcineurin-NFAT signaling pathway -KIFC1 KIFC1 Microtubule-binding; Motility/polarity/chemotaxis; Motor Q9BW19 3833 6p21.32 human S6-p 12667678 __MDPQRsPLLEVKG protein stabilization cell cycle regulation 24510915 2 19 0 -Htt Huntingtin Cytoskeletal P42859 15194 5 B2|5 17.92 cM mouse S1159-p 465621 LTNPPSLsPIRRKGK intracellular localization cell differentiation, inhibited; exocytosis, inhibited; cell growth, inhibited; apoptosis, inhibited; transcription, inhibited 17611284; 23678106; 32640230 4 9 20 -Bcl2l11 BIM Apoptosis O54918 12125 2|2 F1 mouse S100-p 449602 FSFDTDRsPAPMSCD protein stabilization; molecular association, regulation apoptosis, altered; apoptosis, induced Bcl-2(INDUCES); Bcl-xL(INDUCES); BAX(DISRUPTS) 15486085; 23832115 8 2 0 -CASP2 CASP2 Apoptosis; EC 3.4.22.55; Protease P42575 835 7q34 human S139-p 6835500 LSCDYDLsLPFPVCE molecular association, regulation; protein processing; enzymatic activity, induced cell cycle regulation 14-3-3 zeta(INDUCES) 19203584; 28943433 2 2 0 -CEBPA C/EBP-alpha DNA-binding; Transcription factor P49715 1050 19q13.11 human R35-m1 1878324500 SAAFGFPrGAGPAQP cell cycle regulation; carcinogenesis, induced; cell growth, induced; transcription, inhibited HDAC3(DISRUPTS) 31015230 1 1 0 -CBLB Cbl-b Adaptor/scaffold; Calcium-binding; EC 6.3.2.-; Ligase; UBIQUITIN LIGASE; Ubiquitin conjugating system; Ubiquitin ligase Q13191 868 3q13.11 human Y363-p 455017 TQEQYELyCEMGSTF molecular association, regulation; ubiquitination; protein conformation; enzymatic activity, induced UBE2D1(INDUCES) 22158902; 26416283 3 9 75 -HNF4A HNF4 alpha DNA-binding; Nuclear receptor; Transcription factor P41235 3172 20q13.12 human K106-ac 460631 SRQCVVDkDKRNQCR zf-C4 molecular association, regulation; intracellular localization; protein conformation transcription, induced Exportin-1(DISRUPTS); CBP(INDUCES) DNA(INDUCES) 10882110 1 1 0 -Pcyt2 PCYT2 EC 2.7.7.14; Lipid Metabolism - glycerophospholipid; Transferase Q922E4 68671 11|11 E2 mouse S215-p 31834925 VSQFLQTsQKIIQFA enzymatic activity, induced cell growth, induced 24519946 1 1 0 -PTBP1 hnRNP I iso1 RNA splicing; RNA-binding P26599-1 5725 19p13.3 human S16-p 450288 AVGTKRGsDELFSTC intracellular localization 12851456 1 10 0 -Irs1 IRS1 Adaptor/scaffold; Motility/polarity/chemotaxis P35570 25467 9q34 rat Y1172-p 451288 GLEKSLNyIDLDLVK molecular association, regulation GRB2(INDUCES); SHP-2(INDUCES) 7504175; 7588273 5 6 21 -GNA13 G-alpha 13 G protein; G protein, heterotrimeric; G protein, heterotrimeric alpha G(12) Q14344 10672 17q24.1 human T203-p 448723 ILLARRPtKGIHEYD G-alpha molecular association, regulation TXA2-R iso2(INDUCES) 12399457 1 0 1 -BORA BORA Activator Q6PGQ7 79866 13q21.33 human S41-p 11452210 LHEQTLAsPSVFKST BORA_N molecular association, regulation cell cycle regulation PLK1(INDUCES) 27068477 2 2 0 -Igf2bp1 IGF2BP1 RNA-binding; Translation O88477 140486 11 D|11 59.08 cM mouse Y396-p 458348 SVTGAAPySSFMQAP cell growth, induced; translation, induced 21964071 6 0 0 optimally support axon outgrowth; localization release, and translation of GAP-43 mRNAs -PHLPP1 PHLPP EC 3.1.3.16; PHOSPHATASE; Protein phosphatase, Ser/Thr (non-receptor); Tumor suppressor O60346 23239 18q21.33 human S1359-p 22769300 VPRPHVQsVLLTPQD PP2C protein degradation 19797085 1 1 0 PHLPP phosphorylation induces degradation and Akt1 activation negatively regulates degradation. -MAPT Tau iso8 ACETYLTRANSFERASE; Acetyltransferase; Cytoskeletal P10636-8 4137 17q21.31 human T212-p 447934 TPGSRSRtPSLPTPP O-GlcNAc glycosylation; molecular association, regulation; intracellular localization; protein processing; protein conformation apoptosis, altered; cytoskeletal reorganization WWOX(INDUCES); Tau iso8(INDUCES); TUBA1A(INDUCES); PIN1(INDUCES) 15126504; 15190058; 15364924; 15542598; 16024016; 16987243; 18725412; 19451179; 20550628; 20663882 52 16 5 induced tau-tau association and formed aggregates in cell nucleus -TGM2 TGM2 EC 2.3.2.13; KINASE; Transferase P21980 7052 20q11.23 human T162-p 1874101934 ERQEYVLtQQGFIYQ intracellular localization DNA repair, induced 34225780 1 0 0 -AURKB AurB EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, Other; Protein kinase, Ser/Thr (non-receptor) Q96GD4 9212 17p13.1 human K85-ub 21129746 EIGRPLGkGKFGNVY Pkinase intracellular localization; enzymatic activity, induced 35853811 1 2 0 localization of TbRI in the midbody during cell division -BSG BSG Immunoglobulin superfamily; Membrane protein, integral P35613 682 19p13.3 human K375-ub 12408986 SGQHQNDkGKNVRQR carcinogenesis, induced; cell motility, induced; cell growth, induced; transcription, induced 26769849 1 2 4 -Ikbkb IKKB EC 2.7.11.10; KINASE; Kinase, protein; Protein kinase, Other; Protein kinase, Ser/Thr (non-receptor) O88351 16150 8|8 A2 mouse Y199-p 449633 ELLEQQKyTVTVDYW Pkinase phosphorylation; enzymatic activity, induced cell differentiation, induced; signaling pathway regulation 20534585; 30514903 6 1 0 Y188/199 of IKK? and Y179 TBK1 phosphorylation induce activation of TLR signaling; osteoclast differentiation -FHL2 FHL2 Motility/polarity/chemotaxis; Nuclear receptor co-regulator; Transcription, coactivator/corepressor Q14192 2274 2q12.2 human Y97-p 473390 TDCYSNEySSKCQEC LIM cell cycle regulation; cell growth, inhibited 33932144 1 1 5 -AR AR DNA-binding; Nuclear receptor; Transcription factor P10275 367 Xq12 human K633-ac 458905 TLGARKLkKLGNLKL activity, induced; protein stabilization; molecular association, regulation; intracellular localization; phosphorylation carcinogenesis, induced; carcinogenesis, inhibited; apoptosis, induced; transcription, induced; transcription, altered; signaling pathway regulation p300(INDUCES) 10779504; 11971970; 11994312; 15123687; 16860317; 17483368; 18022799; 22131404; 28511652 9 1 0 -CALD1 Caldesmon Actin-binding P12957 373965 chicken S642-p 15668102 SRLEQYTsAVVGNKA Caldesmon molecular association, regulation Caldesmon(DISRUPTS) 20858431 0 3 1 enhances effect of S672 and S702 phosphorylation to weaken interaction -ACTA1 ACTA1 Cell development/differentiation; Contractile; Cytoskeletal; Motility/polarity/chemotaxis P68135 rabbit K70-ac 474929 KRGILTLkYPIEHGI Actin activity, inhibited 30962575 1 6 10 CAP/actin inhibitory potency -HNRNPC hnRNP C1/C2 RNA splicing; RNA-binding; Spliceosome P07910 3183 14q11.2 human S299-p 448834 EGEDDRDsANGEDDS molecular association, regulation RNA(NOT_REPORTED) 15687492 3 64 87 -Ceacam1 CEACAM1 Cell adhesion; Immunoglobulin superfamily; Membrane protein, integral; Motility/polarity/chemotaxis P31809 26365 7 A3|7 13.84 cM mouse Y515-p 451429 PRATETVySEVKKK_ molecular association, regulation; intracellular localization SHP-2(INDUCES) 14970258; 9867848 5 2 37 -Htt Huntingtin Cytoskeletal P51111 29424 14q21 rat S1150-p 465621 LTNPPSLsPIRRKGK apoptosis, inhibited 17611284 4 9 20 regulates neuronal death through a p53-dependent pathway -F3 F3 Cell surface; Membrane protein, integral P20352 14066 3 G1|3 52.94 cM mouse S247-p 1874500400 VCTEQWKsFLGETLI cell growth, induced; apoptosis, inhibited 34359738 1 0 0 -KCNK9 KCNK9 Membrane protein, integral; Membrane protein, multi-pass Q9NPC2 51305 8q24.3 human T341-p 40686300 IEEISPStLKNSLFP activity, inhibited 17374744 1 0 0 PKCA mediated inhibition of channel current -TAOK1 TAO1 EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, STE; Protein kinase, Ser/Thr (non-receptor) Q7L7X3 57551 17q11.2 human T785-p 3627516 SINEMLStQALRLDE activity, induced cell cycle regulation 17396146 1 0 0 -CXCR4 CXCR4 GPCR, family 1; Membrane protein, integral; Membrane protein, multi-pass; Receptor, GPCR P61073 7852 2q22.1 human K333-ub 12324743 LKILSKGkRGGHSSV protein degradation 24489825 1 1 1 -Tbk1 TBK1 EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, Other; Protein kinase, Ser/Thr (non-receptor) Q9WUN2 56480 10|10 D2 mouse K670-ub 59149202 LAASGGVkHAMAPIY protein stabilization signaling pathway regulation 27692986 1 1 0 regulates IFN-1 signaling and antiviral innate immunity -Ap2m1 AP2M1 Adaptor/scaffold; Vesicle P84092 116563 11q23 rat T156-p 448782 SQITSQVtGQIGWRR molecular association, regulation; intracellular localization; protein conformation TGOLN2(INDUCES) 11516654; 15916959 9 33 29 T156A mutants are defective in the endocytosis of labelled transferrin. Although the paper demonstrates a functional correlation between T156 and endocytosis, it does not directly prove that this effect is due to phosphorylation.; increased binding to Yxx(hydrophobic) peptides such as TGOLN2 sorting signal (DYQRLN) and to phospholipids (PtdIns4,5P2-containing liposomes) -Tp63 p63 DNA-binding; Transcription factor O88898 22061 16 B1|16 17.37 cM mouse T567-p 20506701 SCLDYFTtQGLTTIY SAM_2 activity, induced 21325887 1 0 0 -IRS2 IRS2 Adaptor/scaffold; Motility/polarity/chemotaxis Q9Y4H2 8660 13q34 human Y675-p 454968 GSCRSDDyMPMSPAS molecular association, regulation PIK3C2A(INDUCES) 30459283 3 30 343 -SOX10 SOX10 Cell development/differentiation; DNA-binding; Transcription factor P56693 6663 22q13.1 human S24-p 7103084 SEEPRCLsPGSAPSL Sox_N protein stabilization cell differentiation, induced; transcription, induced; transcription, inhibited 29315345; 37481722 2 6 0 -SLBP SLBP RNA-binding Q14493 7884 4p16.3 human T61-p 466351 ERRPESFtTPEGPKP protein degradation; molecular association, regulation CUL4A(INDUCES); WDR23(INDUCES) 12588979; 18490441; 27254819 4 3 9 -DUSP3 DUSP3 EC 3.1.3.16; EC 3.1.3.48; Motility/polarity/chemotaxis; PHOSPHATASE; Protein phosphatase, dual-specificity P51452 1845 17q21.31 human Y138-p 448718 SPTLVIAyLMMRQKM DSPc enzymatic activity, induced 12447358 1 2 0 When ZAP-70 was reintroduced into the ZAP-70(-) JURKAT cells, DUSP3 regained its ability to inhibit MAPK responses. -ZFP36 TTP DNA-binding; RNA-binding P26651 7538 19q13.2 human S60-p 451150 RLPGRSTsLVEGRSC molecular association, regulation carcinogenesis, induced; RNA stability, induced RNA(INDUCES) 37210725 11 16 0 -CASP2 CASP2 Apoptosis; EC 3.4.22.55; Protease P42575 835 7q34 human S157-p 456810 LYKKLRLsTDTVEHS protein conformation; activity, inhibited 16193064 1 5 0 lack of phosphorylation of this residue leads to Casp's dimerization and activation -Cacng2 Stargazin Channel, calcium; Membrane protein, integral; Membrane protein, multi-pass O88602 12300 15 E1|15 36.92 cM mouse S253-p 455307 PSHSRDAsPVGVKGF activity, induced; intracellular localization 15664178; 20670832 3 7 0 AMPAR immobilization in synaptic membrane; enhances AMPA receptor responses and is required for long-term potentiation -Nf2 Merlin Cytoskeletal; Motility/polarity/chemotaxis; Tumor suppressor P46662 18016 11 A1|11 3.0 cM mouse S518-p 448282 DTDMKRLsMEIEKEK ERM_C cytoskeletal reorganization; cell growth, altered 20668201 33 41 1 neurite outgrowth -XRCC5 Ku80 DNA-binding; EC 3.6.1.-; EC 3.6.4.-; Helicase; Nuclear receptor co-regulator; Nucleolus; RNA-binding P13010 7520 2q35 human K443-ub 21177862 SSLKNSKkYAPTEAQ Ku molecular association, regulation DNA repair, induced DNA(DISRUPTS) 27895153 1 5 0 -EZH2 EZH2 iso2 EC 2.1.1.43; METHYLTRANSFERASE; Methyltransferase; Methyltransferase, protein lysine Q15910-2 2146 7q36.1 human S652-p 29606714 EYCGEIIsQDEADRR SET molecular association, regulation cell cycle regulation; DNA repair, induced SUZ12(DISRUPTS); EED(DISRUPTS) 24162653 1 0 0 -CDCA5 CDCA5 Cell cycle regulation Q96FF9 113130 11q13.1 human T151-p 28750703 RSYSRLEtLGSASTS Sororin activity, inhibited cell cycle regulation SCC-112(DISRUPTS) 23901111 1 2 0 -Pdx1 PDX1 DNA-binding; Transcription factor P52946 18609 5 G3|5 86.84 cM mouse T152-p 470134 EENKRTRtAYTRAQL Homeodomain intracellular localization 17052199 1 0 0 -PTK2 FAK EC 2.7.10.2; KINASE; Kinase, protein; Protein kinase, TK; Protein kinase, tyrosine (non-receptor) Q00944 396416 chicken Y577-p 447890 YMEDSTYyKASKGKL PK_Tyr_Ser-Thr activity, induced; phosphorylation; enzymatic activity, induced 12370821; 9790958 88 40 1747 -AHR AHR DNA-binding; Transcription factor P35869 196 7p21.1 human S689-p 1874101922 SQEFPYKsEMDSMPY protein degradation; ubiquitination autophagy, induced; transcription, induced 34198826 1 0 0 -MAP2K4 MKK4 EC 2.7.12.2; KINASE; Kinase, protein; Protein kinase, STE; Protein kinase, dual-specificity (non-receptor) P45985 6416 17p12 human K143-ub 11998603 TVDEKEQkQLLMDLD Pkinase protein degradation 19737936 1 0 0 -GTF2I GTF2I iso2 DNA-binding; Transcription, coactivator/corepressor P78347-2 2969 7q11.23 human Y462-p 448252 EAHPNDLyVEGLPEN GTF2I transcription, altered 11373296 1 3 2 -Tek TIE2 EC 2.7.10.1; KINASE; Kinase, protein; Membrane protein, integral; Protein kinase, TK; Protein kinase, tyrosine (receptor) Q02858 21687 4 C5|4 43.34 cM mouse Y1100-p 450256 MLEERKTyVNTTLYE molecular association, regulation transcription, altered GRB2(INDUCES); GRB7(INDUCES); SHP-2(INDUCES); GRB14(INDUCES); PIK3R1(INDUCES) 10521483; 11865050 5 0 0 -EGLN2 EGLN2 EC 1.14.11.29; Oxidoreductase Q96KS0 112398 19q13.2 human S234-p 4213802 QRAIPPRsIRGDQIA enzymatic activity, inhibited 18710826 1 0 0 -BCL2L1 Bcl-xL Apoptosis; Autophagy; Membrane protein, integral; Mitochondrial Q07817 598 20q11.21 human S145-p 1873647708 GRIVAFFsFGGALCV Bcl-2 protein stabilization; molecular association, regulation carcinogenesis, induced; apoptosis, inhibited RNF152(DISRUPTS) 34098062 1 0 0 inhibits ubiquitination -ABL1 Abl iso2 EC 2.7.10.2; KINASE; Kinase, protein; Oncoprotein; Protein kinase, TK; Protein kinase, tyrosine (non-receptor) P00519-2 25 9q34.12 human S69-p 461026 SEAARWNsKENLLAG protein conformation 16543148 1 2 18 role in autoinhibition of enzyme -TOB2 TOB2 Q14106 10766 22q13.2 human S254-p 14161520 PAPQSQLsPNAKEFV PAM2 molecular association, regulation cell growth, inhibited; RNA stability, inhibited CCR4(INDUCES); PABP 1(INDUCES); NOT1(INDUCES) 32404348 1 5 0 -CTNND1 CTNND1 Actin-binding; Adaptor/scaffold; Cell adhesion; G protein regulator, misc.; Motility/polarity/chemotaxis O60716 1500 11q12.1 human T916-p 450454 ERGDHNRtLDRSGDL carcinogenesis, induced; cell motility, induced; cell adhesion, inhibited 32589661 5 26 7 -JAK1 JAK1 EC 2.7.10.2; KINASE; Kinase, protein; Protein kinase, TK; Protein kinase, tyrosine (non-receptor) P23458 3716 1p31.3 human Y1035-p 448452 IETDKEYyTVKDDRD PK_Tyr_Ser-Thr enzymatic activity, induced carcinogenesis, induced; cell motility, induced 32029900; 34380633; 36166512 32 8 46 -PREX1 PREX1 GEF; GEF, Rac/Rho Q8TCU6 57580 20q13.13 human S605-p 18704702 DEEMEGTsSKNKQLR activity, induced 21042280; 27788493 2 0 0 -HABP4 HABP4 Transcription regulation Q5JVS0 22927 9q22.32 human T375-p 11380903 GRGARGGtRGGRGRI IHABP4_N molecular association, regulation; intracellular localization RACK1(DISRUPTS) 14699138 1 0 0 HABP4 associates with RACK1 in the nucleus but exits after activation with PMA -Adrb3 ADRB3 iso2 GPCR, family 1; Membrane protein, integral; Membrane protein, multi-pass; Receptor, GPCR P25962-2 11556 8 A2|8 15.94 cM mouse S389-p 456902 QSPPLNSsLLREPRH activity, induced 16144970 1 0 0 mutation of serines 388 and 389 to alanine abrogated cAMP accumulation in response to CL316243. -RAP1B RAP1B G protein; G protein, monomeric; G protein, monomeric, Ras P61223 327708 cow S180-p 22689703 GKARKKSsCQLL___ intracellular localization; activity, inhibited cell motility, induced RASSF5(DISRUPTS) 23946483 4 0 0 1) Cytosolic relocalization of Rap1 is phosphorylation dependent. 2) Rap1 phosphorylation is necessary for cell migration. 3) Binding of Rap1 to RapL is decreased by PKA-dependent phosphorylation of S180. -Gria1 GluR1 Channel, calcium; Channel, ligand-gated; Membrane protein, integral; Membrane protein, multi-pass P19490 50592 10q22 rat S836-p 467226 CYKSRSEsKRMKGFC activity, induced; intracellular localization signaling pathway regulation 16846856; 23511975 6 0 0 signaling for synaptic incorporation of AMPAR at activated synapses during LTP expression; promotes receptor incorporation into the synapse -SOS1 SOS1 Adaptor/scaffold; GEF; GEF, Ras; Motility/polarity/chemotaxis Q07889 6654 2p22.1 human S1132-p 451313 TLPHGPRsASVSSIS molecular association, regulation GRB2(DISRUPTS) 8816480 1 0 0 -CENPT CENPT DNA replication F1NPG5 chicken T72-p 3903606 FSELDNAtPRVMLRK CENP-T_N molecular association, regulation SPC25(INDUCES); SPBC24(INDUCES) 23334297 3 5 9 -MAP3K7 TAK1 EC 2.7.11.25; KINASE; Kinase, protein; Protein kinase, Ser/Thr (non-receptor); Protein kinase, TKL O43318 6885 6q15 human Y206-p 1869056901 EVFEGSNySEKCDVF PK_Tyr_Ser-Thr ubiquitination; phosphorylation 32403971 1 0 0 -SGK3 SGK3 EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, AGC; Protein kinase, Ser/Thr (non-receptor) Q96BR1 23678 8q13.1 human T320-p 448197 AISDTTTtFCGTPEY Pkinase phosphorylation; enzymatic activity, induced 31821448; 34181950 8 3 0 induces substrate phosphorylation; lost in SGK3 c.979-96TgtA variant -CASP9 CASP9 Apoptosis; EC 3.4.22.62; Protease P55211 842 1p36.21 human S183-p 448528 GLRTRTGsNIDCEKL Peptidase_C14 molecular association, regulation; enzymatic activity, inhibited; protein conformation APAF(DISRUPTS) 15703181; 29352269 2 0 0 forms higher order oligomers or aggregates, unfolds and disassembles the casp-9 core; inhibits the assembly of the apoptosome in response to cytochrome c -TNNI3 TNNI3 Actin-binding; Motility/polarity/chemotaxis; Motor P19429 7137 19q13.42 human T51-p 6796402 SRKLQLKtLLLQIAK Troponin molecular association, regulation; protein conformation C16orf82(INDUCES); TNC(INDUCES) 18986304 1 1 0 -TRPA1 TRPA1 Membrane protein, integral; Membrane protein, multi-pass O75762 8989 8q21.11 human T673-p 56672700 PLEFTKKtPTQDVIY activity, induced 27345869 1 0 0 -CDC25B CDC25B iso2 EC 3.1.3.48; Motility/polarity/chemotaxis; Nuclear receptor co-regulator; PHOSPHATASE; Protein phosphatase, dual-specificity P30305-2 994 20p13 human S309-p 448409 QRLFRSPsMPCSVIR M-inducer_phosp phosphorylation P38A(INDUCES) 17548358 13 9 30 phospho-p38 are Cdc25B S309-p are colocalized during prophase. -SIRT2 SIRT2 iso2 DEACETYLASE; Deacetylase; EC 3.5.1.- Q8IXJ6-2 22933 19q13.2 human K183-sm 1881502500 IFSEVTPkCEDCQSL enzymatic activity, inhibited carcinogenesis, inhibited 33316537 1 0 0 SIRT2 is the deacetylase of P38 and its enzyme activity is inhibited by its SUMOylation, SUMOylation inhibits the carcinogenic phenotype in neurblastoma cells and is a tumor suppressor in mice -IFNAR1 IFNAR1 Membrane protein, integral; Receptor, cytokine P17181 3454 21q22.11 human S532-p 11927800 KKYSSQTsQDSGNYS protein degradation; ubiquitination; activity, inhibited; phosphorylation apoptosis, inhibited; signaling pathway regulation 19948722; 21666722; 21695243; 28122987 5 0 0 regulation of PERK1 pathway; attenuation of INF alpha/beta signaling; induces phosphorylation at S535 -SLC6A4 SERT Membrane protein, integral; Membrane protein, multi-pass; Transporter P31645 6532 17q11.2 human T81-p 12610000 LHQGEREtWGKKVDF SNF protein conformation 20118234 1 0 0 -MVB12A FAM125A Adaptor/scaffold Q96EY5 93343 19p13.11 human T130-p 13211302 RLSGKTKtVPGYLRI DUF2464 protein processing 18005716 1 1 0 inhibition of HIV-1 release and infectivity -EIF4A2 EIF4A2 EC 3.6.4.13; Helicase; RNA-binding; Translation; Translation initiation Q14240 1974 3q27.3 human K226-sm 55610205 TDVLEVTkKFMRDPI intracellular localization 27160682 1 1 0 -FCER1G FCER1G Membrane protein, integral; Receptor, misc. P30273 2207 1q23.3 human S69-p 13310016 DGVYTGLsTRNQETY ITAM molecular association, regulation Syk(DISRUPTS) 27630214 1 8 0 -KAT7 MYST2 ACETYLTRANSFERASE; Acetyltransferase; EC 2.3.1.48; Nuclear receptor co-regulator; Transcription, coactivator/corepressor O95251 11143 17q21.33 human K576-ub 1877197200 KGKHLVLkRQDLIDE protein degradation 32555450 1 1 0 degraded during differentiation -CHEK2 Chk2 EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, CAMK; Protein kinase, Ser/Thr (non-receptor); Tumor suppressor O96017 11200 22q12.1 human S379-p 981401 SKILGETsLMRTLCG Pkinase ubiquitination; intracellular localization; enzymatic activity, induced apoptosis, induced 18644861; 20713355 4 12 1 -Rasgrp1 RASGRP1 GEF; GEF, Ras Q9Z1S3 19419 2 E5|2 59.19 cM mouse T184-p 456226 RDWSRKLtQRIKSNT carcinogenesis, induced 22116551 3 0 0 -Ptpn6 SHP-1 EC 3.1.3.48; Motility/polarity/chemotaxis; PHOSPHATASE; Protein phosphatase, tyrosine (non-receptor) P81718 116689 4q42 rat Y543-p 449656 SEYGNITyPPALRSA molecular association, regulation PIK3R1(INDUCES) 9452499 1 2 214 -Mnx1 MNX1 DNA-binding Q9QZW9 15285 5|5 B1 mouse S80-p 3191344 RLRAESPsPPRLLAA molecular association, regulation; intracellular localization cell motility, altered; transcription, inhibited NONO(INDUCES) DNA(INDUCES) 24425879; 26342078 2 17 1 nuclear localization; nuclear localization, inhibits Cbl-b transcription -CFTR CFTR Channel, chloride; EC 3.6.3.49; Hydrolase; Membrane protein, integral; Membrane protein, multi-pass; Transporter; Transporter, ABC family P13569 1080 7q31.2 human S700-p 449978 FGEKRKNsILNPINS CFTR_R molecular association, regulation; enzymatic activity, inhibited CFTR(INDUCES) 14602047 9 7 0 -CXCR4 CXCR4 GPCR, family 1; Membrane protein, integral; Membrane protein, multi-pass; Receptor, GPCR P61073 7852 2q22.1 human S339-p 458320 GKRGGHSsVSTESES activity, induced; receptor internalization, induced; intracellular localization cell growth, induced; cell growth, inhibited 19687226; 24632620; 26212080; 30327409 14 6 7 cytoplasmic localization; colony forming of cKit+ AML cells -Ntrk3 TrkC EC 2.7.10.1; KINASE; Kinase, protein; Membrane protein, integral; Protein kinase, TK; Protein kinase, tyrosine (receptor) Q03351 29613 1q31 rat Y516-p 450003 PVIENPQyFRQGHNC molecular association, regulation PLCG1(INDUCES); SHC1(INDUCES) 7657612 2 5 66 -Mlycd MLYCD Carbohydrate Metabolism - propanoate; EC 4.1.1.9; Lyase; Other Amino Acids Metabolism - beta-alanine Q99J39 56690 8|8 E1 mouse K471-ac 36957911 SISYLGSkNIKASEQ enzymatic activity, induced 23746352 1 2 0 regulates lipogenesis and FAO -FOXA2 FOXA2 DNA-binding; Transcription factor Q9Y261 3170 20p11.21 human K6-ac 33602701 __MLGAVkMEGHEPS protein stabilization transcription, induced 24875183 1 1 0 -PIN4 PIN4 EC 5.2.1.8; Isomerase; Mitochondrial; Nucleolus Q9Y237 5303 Xq13.1 human S19-p 3188102 AGKGGAAsGSDSADK molecular association, regulation; intracellular localization DNA(DISRUPTS) 12860119 1 0 0 -H3C1 H3 DNA-binding P68431 8350 6p22.2 human S57-p 481136 EIRRYQKsTELLIRK Histone DNA repair, altered; transcription, altered; cell growth, altered 20520775 2 19 9 -AMPH amphiphysin Vesicle P49418 273 7p14.1 human T445-p 10793310 EEPLAAVtPAVGLDL neural plasticity; apoptosis, inhibited 35858575 1 1 1 -Cebpb C/EBP-beta DNA-binding; Motility/polarity/chemotaxis; Transcription factor P28033 12608 2 H3|2 87.58 cM mouse S180-gl 7789200 SSGSLSTsSSSSPPG molecular association, regulation; phosphorylation cell differentiation, inhibited; transcription, inhibited DNA(DISRUPTS) 19478079 1 1 0 prevents phosphorylation of T179, S184, T188 -SOX2 SOX2 Cell development/differentiation; DNA-binding; Transcription factor P48431 6657 3q26.33 human Y277-p 27722639 LRDMISMyLPGAEVP protein stabilization; molecular association, regulation carcinogenesis, induced; autophagy, induced SQSTM1(DISRUPTS) 31823521 1 1 0 decrease ubiquitination and subsequent autophagic degradation -FYB1 SLAP-130 Adaptor/scaffold O15117 2533 5p13.1 human Y755-p 464285 CRNEEGKyGYVLRSY hSH3 cell motility, altered; cell adhesion, altered 20661443 1 4 185 promotes adhesion to ICAM-1; promotes cell migration -Kcnd2 Kv4.2 Channel, potassium; Membrane protein, integral; Membrane protein, multi-pass Q63881 rat T607-p 457612 IPTPPVTtPEGDDRP neural plasticity 35625355 7 0 0 -Tbc1d4 AS160 GAP; GAP, Rab Q8BYJ6 210789 14|14 E2.3 mouse S711-p 2226513 PSLHTSFsAPSFTAP phosphorylation 33872597 7 3 0 affects phosphorylation of other sites by AKT -Arrb2 ARRB2 Adaptor/scaffold Q91YI4 216869 11 B3|11 42.99 cM mouse S361-p 3176604 ITLPRPQsAPRETDV molecular association, regulation; receptor internalization, altered CLTC(DISRUPTS) 12186555 2 5 0 decreases beta2-adrenergic receptor internalization -MTSS1 MTSS1 Adaptor/scaffold; Motility/polarity/chemotaxis; Tumor suppressor O43312 9788 8q24.13 human S322-p 4763951 SSVSSHDsGFISQDA protein degradation; molecular association, regulation; ubiquitination cell motility, induced; cell growth, induced BTRC(INDUCES) 24318128 1 1 0 -Eif2ak3 PERK EC 2.7.11.1; KINASE; Kinase, protein; Membrane protein, integral; Protein kinase, Other; Protein kinase, Ser/Thr (non-receptor); Translation Q9Z2B5 13666 6|6 C1 mouse T799-p 11073906 YTRSREGtSSSIVFE molecular association, regulation; enzymatic activity, inhibited apoptosis, induced; apoptosis, inhibited Elf-2(DISRUPTS) 21954288; 32788341 3 0 1 Phosphorylation inactivates PERK, promoting proapoptotic effects of Akt.; PERK-elf2a sugnaling in neurodegenerative diseases -ZDHHC13 ZDHHC13 EC 2.3.1.225; Membrane protein, integral; Membrane protein, multi-pass; Transferase Q8IUH4 54503 11p15.1 human S208-p 1880741000 FLLKFNPsLNVVDKI molecular association, regulation; palmitoylation cell cycle regulation; DNA repair, induced; carcinogenesis, inhibited; transcription, induced; signaling pathway regulation MC1R(INDUCES) 36701140 1 1 0 induces MC1R-RHC downstream signaling -FANCA FANCA DNA repair, damage O15360 2175 16q24.3 human S165-p 56757905 HSMFSRLsFCQELWK ubiquitination; intracellular localization DNA repair, induced 27398318 1 0 0 nuclear foci formation -EEF2 EEF2 Translation; Translation elongation P13639 1938 19p13.3 human Y373-p 459352 KYRCELLyEGPPDDE sumoylation 24648518 1 2 44 induces sumoylation at K322 and K529 -GAB2 GAB2 Adaptor/scaffold Q9UQC2 9846 11q14.1 human Y266-p 448878 TEFRDSTyDLPRSLA molecular association, regulation CRKL(INDUCES) 11334882 1 13 228 -Myh14 MYH14 Motility/polarity/chemotaxis; Motor Q6URW6 71960 7|7 B3 mouse T1957-p 27623908 RRGPLTFtTRTVRQV cytoskeletal reorganization 23426373 1 0 0 Phosphorylation of either residue abolishes filament assembly of MYH14 Rod1296-1854. -RB1 Rb Nuclear receptor co-regulator; Oncoprotein; Transcription, coactivator/corepressor; Tumor suppressor P06400 5925 13q14.2 human S807-p 447980 PGGNIYIsPLKSPYK Rb_C molecular association, regulation; phosphorylation cell cycle regulation; carcinogenesis, induced; cell growth, induced; transcription, induced; transcription, altered; cell growth, altered ID2(DISRUPTS); E2F1(DISRUPTS); Abl iso2(DISRUPTS) 10969768; 15028555; 15619620; 16007177; 25698448; 32093423; 32094692; 33556114; 34108622; 34209868; 34247189; 34462276; 35194151; 35235778; 35437308; 36603130; 8626527; 9315635 102 45 112 -GRK2 GRK2 EC 2.7.11.15; KINASE; Kinase, protein; Protein kinase, AGC; Protein kinase, Ser/Thr (non-receptor) P21146 282682 cow Y86-p 447727 AKPLVEFyEEIKKYE RGS enzymatic activity, induced 18463167 5 0 0 -DES desmin Cytoskeletal; Motility/polarity/chemotaxis P17661 1674 2q35 human S12-p 449612 YSSSQRVsSYRRTFG Filament_head intracellular localization cytoskeletal reorganization 12686604 1 0 0 Mutated desmin sites showed failure of desmin filaments to segregate into daughter cells. ; Phosphorylated at the clevage furrow during cytokinesis. -MOB1A MOB1A Protein kinase, regulatory subunit Q9H8S9 55233 2p13.1 human K11-ac 9911535 LFSSRSSkTFKPKKN protein stabilization; molecular association, regulation; intracellular localization carcinogenesis, inhibited; transcription, inhibited; signaling pathway regulation LATS1(INDUCES) 35349706 1 0 1 MOB1 acetylation mediates oxidative stress regulation of the Hippo pathway, inhibits YAP/TAZ nuclear translocation, suppression of lung cancer cell proliferation, MOB1 acetylation inhibits migration, invasion in vitro and tumor growth in vivo -LSM4 LSM4 RNA-binding; Spliceosome Q9Y4Z0 25804 19p13.11 human R102-m2 15381281 QQKQQKGrGMGGAGR molecular association, regulation SMN(INDUCES) 11720283 1 1 3 -PHB2 BAP37 Mitochondrial; Nuclear receptor co-regulator; Transcription, coactivator/corepressor Q99623 11331 12p13.31 human K142-ub 573782384 SIVNEVLkSVVAKFN Band_7 molecular association, regulation; ubiquitination autophagy, induced LC3B(INDUCES) 36379251 1 1 0 BAP37 promotes ef?cient mitophagy -Pla2g4a PLA2G4A EC 3.1.1.4; EC 3.1.1.5; Lipid Metabolism - alpha-linolenic acid; Lipid Metabolism - arachidonic acid; Lipid Metabolism - ether lipid; Lipid Metabolism - glycerophospholipid; Lipid Metabolism - linoleic acid; Phospholipase P47713 18783 1 G1|1 63.51 cM mouse S505-p 447597 LNTSYPLsPLRDFSS PLA2_B enzymatic activity, induced 10978317; 8381049 25 6 8 -TCF3 E2A Cell development/differentiation; DNA-binding; Oncoprotein; Transcription factor P15923 6929 19p13.3 human S352-p 465681 SSNNFSSsPSTPVGS activity, inhibited transcription, inhibited 19801649 2 1 4 -Nlrp3 NLRP3 Inhibitor Q8R4B8 216799 11|11 B1.3 mouse S194-p 230295300 GRTKMRDsPMSSLKL FISNA protein stabilization; molecular association, regulation ABRAXAS2(INDUCES) 30787184 5 2 0 deubiquitination induced -LRP5 LRP5 Membrane protein, integral; Receptor, misc. O75197 4041 11q13.2 human T1492-p 23122924 SSSSTKAtLYPPILN enzymatic activity, induced 34205318 1 0 1 regulates HIF1A stability by inducing hydroxylation activity of PHD2 -PEAK1 PEAK1 EC 2.7.10.2; KINASE; Kinase, protein; Protein kinase, Other; Protein kinase, Ser/Thr (non-receptor) Q9H792 79834 15q24.3 human Y665-p 450418 TSVISHTyEEIETES intracellular localization cell motility, induced; cell adhesion, induced 23105102 1 4 26 Src activity is required for SgK269 localization to focal adhesions and SgK269 adhesion effects. -PAX3 PAX3 DNA-binding; Oncoprotein; Transcription factor P23760 5077 2q36.1 human K437-ac 25042100 SQRLDHMkSLDSLPT molecular association, regulation cell growth, inhibited; cell differentiation, induced; transcription, altered DNA(INDUCES) 21169561 1 0 0 K437 decreases Hes1 transcription, K437 and K475 increase transcription of Neurog2 -INCENP INCENP Cell cycle regulation; EC 2.7.11.1 Q9NQS7 3619 11q12.3 human S893-p 450467 PRYHKRTsSAVWNSP activity, induced; protein stabilization; molecular association, regulation; enzymatic activity, induced INCENP(INDUCES) 12925766; 27332895; 32028528 8 16 15 induces AurB activity -ULK1 ULK1 Autophagy; EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, Other; Protein kinase, Ser/Thr (non-receptor) O75385 8408 12q24.33 human S495-p 6220991 GVLARKMsLGGGRPY protein degradation; molecular association, regulation; ubiquitination; enzymatic activity, inhibited carcinogenesis, induced; cell growth, induced; apoptosis, inhibited; autophagy, inhibited ATG13(DISRUPTS); TRIM27(INDUCES); ATG101(DISRUPTS); RB1CC1(DISRUPTS) 31378785; 35670107 2 3 3 -TOB1 TOB1 Adaptor/scaffold; Cell cycle regulation P50616 10140 17q21.33 human S164-p 455537 FGHSAAVsPTFMPRS activity, inhibited cell cycle regulation; cell growth, inhibited; cell growth, altered 12050114; 12151396; 22252318 4 0 0 promote mRNA deadenylaion and decay and the ability to suppress proliferation; the antiproliferative activity of TOB1 is inhibited by phosphorylation.; the antiproliferative function of TOB1 is inhibited by phosphorylation. -Ep300 p300 ACETYLTRANSFERASE; Acetyltransferase; EC 2.3.1.48; Motility/polarity/chemotaxis; Nuclear receptor co-regulator; Transcription, coactivator/corepressor B2RWS6 328572 15|15 E1 mouse S1833-p 447591 MLRRRMAsMQRTGVA molecular association, regulation cell differentiation, induced MyoD(INDUCES) 17964260 9 0 0 Muscle differentiation -DNMT1 DNMT1 Amino Acid Metabolism - cysteine and methionine; Cell development/differentiation; EC 2.1.1.37; METHYLTRANSFERASE; Methyltransferase; Methyltransferase, DNA; Transcription regulation P26358 1786 19p13.2 human K1115-ac 466146 NKGKGKGkGKGKPKS cell cycle regulation; transcription, inhibited 21947282 1 4 10 -RPL11 RPL11 Motility/polarity/chemotaxis; Nucleolus; Ribosomal; Translation P62913 6135 1p36.11 human K67-ne 12067602 FGIRRNEkIAVHCTV Ribosomal_L5_C protein stabilization; intracellular localization 19713960 1 0 0 -CDC34 CDC34 EC 6.3.2.19; Ligase; UBIQUITIN LIGASE; Ubiquitin conjugating system; Ubiquitin ligase P49427 997 19p13.3 human T162-p 59049803 KGKDREYtDIIRKQV UQ_con protein degradation; ubiquitination 27786305 1 0 0 -CBLB Cbl-b Adaptor/scaffold; Calcium-binding; EC 6.3.2.-; Ligase; UBIQUITIN LIGASE; Ubiquitin conjugating system; Ubiquitin ligase Q13191 868 3q13.11 human Y106-p 5641270 AQLSENEyFKIYIDS Cbl_N ubiquitination; enzymatic activity, induced 26416283 1 0 2 -Wasf2 WAVE2 Actin-binding; Motility/polarity/chemotaxis Q8BH43 242687 4 D2.3|4 66.22 cM mouse T470-p 56675609 VVGNDVAtILSRRIA protein stabilization 29760073 1 1 0 induces phagocytosis -PDE3B PDE3B EC 3.1.4.17; Membrane protein, integral; Membrane protein, multi-pass; Nucleotide Metabolism - purine; Phosphodiesterase Q13370 5140 11p15.2 human S295-p 447699 VIRPRRRsSCVSLGE enzymatic activity, induced 26031333 4 7 78 activation by insulin -Cited1 CITED1 Nuclear receptor co-regulator P97769 12705 X D|X 45.25 cM mouse S63-p 27937114 KANGVPTsSSGSTSP CITED intracellular localization cell differentiation, induced 23529225 1 0 0 S63/64/65/67/69/73/79/80/84A mutation in CITED1 inhibits its translocation into the nucleus and osteoblasts differentiation -MARCKS MARCKS Actin-binding; Motility/polarity/chemotaxis P29966 4082 6q21 human S170-p 451837 SFKLSGFsFKKNKKE MARCKS exocytosis, inhibited 21762971 11 76 93 induce MUC5AC secretion by cold -Vav3 VAV3 Actin-binding; Adaptor/scaffold; GEF; GEF, Rac/Rho; Motility/polarity/chemotaxis; Nuclear receptor co-regulator Q9R0C8 57257 3|3 F3 mouse Y141-p 4834228 SINDEDIyKGLPDLI cell cycle regulation; cell motility, altered 18515860 0 2 4 -BANF1 BAF DNA-binding O75531 8815 11q13.1 human T2-p 7105310 ______MtTSQKHRD BAF molecular association, regulation; intracellular localization DNA(INDUCES); DNA(DISRUPTS) 16495336; 24600006; 24945635 3 7 0 higher level of viral proteins after infection, AAA mutant inhibits viral protein levels; ser4 phosphorylation alone is sufficient to inhibit DNA binding. Both hyperphosphorylated and unphosphorylated mutants cannot suppress vaccinia DNA replication and its yield -RAF1 RAF1 EC 2.7.11.1; KINASE; Kinase, protein; Oncoprotein; Protein kinase, Ser/Thr (non-receptor); Protein kinase, TKL P04049 5894 3p25.2 human S296-p 455218 SPSALSSsPNNLSPT molecular association, regulation; intracellular localization; enzymatic activity, inhibited; enzymatic activity, induced HRas(DISRUPTS) 15642359; 15664191; 16407412 5 25 46 phosphorylation of S289, S296, and S301 sustains and increases kinase activity -CDKN1A p21Cip1 Cell cycle regulation; Inhibitor P38936 1026 6p21.2 human K163-ac 12615904 RLIFSKRkP______ protein stabilization; molecular association, regulation cell cycle regulation; carcinogenesis, inhibited; cell growth, inhibited C8A(DISRUPTS) 20154723; 23238566 2 1 0 induces senescence and DNA-damage-induced cell cycle arrest -Nr4a3 NR4A3 DNA-binding; Nuclear receptor; Oncoprotein Q9QZB6 18124 4|4 B1 mouse K137-sm 1874485102 PSTSMYFkQSPPSTP protein stabilization; molecular association, regulation; acetylation; activity, inhibited cell growth, inhibited; apoptosis, induced; transcription, inhibited DNA(DISRUPTS) 34383980 1 0 0 inhibits H3 acetylation -NADK2 NADK2 EC 2.7.1.23 Q4G0N4 133686 5p13.2 human S188-p 485700 VNTDPERsEGHLCLP NAD_kinase enzymatic activity, inhibited; enzymatic activity, induced 26577408; 35868311 2 11 0 K76Q and K304Q mutants reduced proline production, K76Q and K304Q mutants and S116A showed reduced catalytic activity, phosphorylation, succinylation, or acetylation could generate a charge repulsion in the active site -APP APP Apoptosis; Cell surface; Membrane protein, integral; Receptor, misc.; Transcription factor P05067 351 21q21.3 human K725-ne 12124803 ITLVMLKkKQYTSIH APP_amyloid transcription, inhibited Fe65(DISRUPTS) 18096514 1 0 0 -Ric8a RIC8A GEF; GEF, misc. NP_001093990 293614 1q41 rat S527-p 3213327 QLSSDPDsDPD____ molecular association, regulation G-alpha i1(INDUCES) 29844055 1 6 0 G-alpha subunit guanine nucleotide exchange; G-alpha subunit folding -Slc12a5 KCC2 iso2 Membrane protein, integral; Membrane protein, multi-pass; Transporter; Transporter, SLC family Q63633-2 171373 3q42 rat S940-p 487533 ITDESRGsIRRKNPA SLC12 activity, induced neural plasticity 31969605 23 5 2 -AKT1 Akt1 EC 2.7.11.1; KINASE; Kinase, protein; Oncoprotein; Protein kinase, AGC; Protein kinase, Ser/Thr (non-receptor) P31749 207 14q32.33 human T479-p 8086741 FSYSASGtA______ molecular association, regulation; phosphorylation; enzymatic activity, induced cell cycle regulation; carcinogenesis, induced; cell growth, induced; apoptosis, inhibited Sin1(INDUCES) 24670654 2 4 12 primed for phosphorylation of S473 -ELMO1 ELMO1 Cytoskeletal; Motility/polarity/chemotaxis Q92556 9844 7p14.2-p14.1 human Y395-p 455874 AKHHQDAyIRIVLEN ELMO_CED12 molecular association, regulation; intracellular localization NCK1(INDUCES); RHOG(INDUCES) 24928514 3 2 0 Nck1 enhances ELMO1 and RhoG interaction and promotes Rac1 activity; localization of ELMO1 to the plasma membrane -Oprm1 MOR-1 GPCR, family 1; Membrane protein, integral; Membrane protein, multi-pass; Receptor, GPCR P42866 18390 10 A1|10 1.85 cM mouse T379-p 20727900 EHPSTANtVDRTNHQ receptor desensitization, induced; receptor internalization, induced; molecular association, regulation endocytosis, induced; signaling pathway regulation ARRB2(INDUCES) 21868358; 23239825; 30018083; 32234959 7 2 0 regulates B-arrestin signaling -NFATC3 NFAT4 DNA-binding; Transcription factor Q12968 4775 16q22.1 human T210-p 11507603 FTLGSPLtSPGGSPG intracellular localization 9630228 1 0 0 cytoplasmic localization (inhibition of nuclear localization) -ERG ERG DNA-binding; Oncoprotein; Transcription factor P11308 2078 21q22.2 human Y183-p 1870421702 FQRLTPSyNADILLS SAM_PNT protein degradation; molecular association, regulation; ubiquitination; phosphorylation carcinogenesis, inhibited; cell growth, inhibited; transcription, inhibited FBXW7(INDUCES) 32871104 1 0 0 -EPHB4 EphB4 EC 2.7.10.1; KINASE; Kinase, protein; Membrane protein, integral; Protein kinase, TK; Protein kinase, tyrosine (receptor) P54760 2050 7q22.1 human Y987-p 451663 TGGPAPQy_______ protein stabilization; protein conformation carcinogenesis, induced 31270394 1 16 347 inhibits ubiquitination -MECP2 MECP2 Transcription, coactivator/corepressor P51608 4204 Xq28 human S423-p 470075 EKMPRGGsLESDGCP neural plasticity 35767654 15 13 0 -PRC1 PRC1 Cell cycle regulation; Cytoskeletal; Microtubule-binding; Motility/polarity/chemotaxis O43663 9055 15q26.1 human T578-p 26331400 SINSVAStYSEFAKD phosphorylation 17351640 1 0 0 Docking site phosphorylation at T616 is regulated T578 phosphorylation. -CLIP1 Restin Cytoskeletal P30622 6249 12q24.31 human S312-p 4769833 ASLKRSPsASSLSSM molecular association, regulation cytoskeletal reorganization TUBA1B(DISRUPTS) 24451569 4 13 1 phosphorylated during mitosis, impairs microtubule (MT) nucleation/polymerization end-tracking in vitro, necessary for kinetichore MT attachment and chromosome alignment -ATP5F1A ATP5A1 EC 3.6.3.14; Energy Metabolism - oxidative phosphorylation; Hydrolase; Membrane protein, integral; Mitochondrial; Transporter P25705 498 18q21.1 human K531-ac 466473 GTIRADGkISEQSDA ATP-synt_ab_C cell growth, inhibited 32002124 1 6 58 tumor growth inhibited (increased in K506/531R mutant) -PRKCD PKCD EC 2.7.11.13; KINASE; Kinase, protein; Nuclear receptor co-regulator; Protein kinase, AGC; Protein kinase, Ser/Thr (non-receptor); Protein kinase, tyrosine (non-receptor); Tumor suppressor Q05655 5580 3p21.1 human Y187-p 447579 WGLNKQGyKCRQCNA C1_1 activity, inhibited; phosphorylation apoptosis, altered; apoptosis, induced 11927579; 18434324 6 0 0 ERK phosphorylation/activation -Cebpb C/EBP-beta DNA-binding; Motility/polarity/chemotaxis; Transcription factor P21272 24253 3q42 rat R114-m1 13373505 YGYVSLGrAGAKAAP molecular association, regulation cell growth, induced; transcription, induced DNA(INDUCES) 20351173 0 1 0 -Ripk1 RIPK1 EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, Ser/Thr (non-receptor); Protein kinase, TKL Q60855 19766 13 A3.3|13 14.01 cM mouse S166-p 27116401 VASFKTWsKLTKEKD PK_Tyr_Ser-Thr molecular association, regulation; enzymatic activity, induced carcinogenesis, inhibited; apoptosis, induced; transcription, induced; signaling pathway regulation TNF-R1(INDUCES) 28701375; 32094226; 32366830; 33914027; 34665642; 34990405; 35430614 36 2 0 -Dcx Doublecortin Cytoskeletal; Motility/polarity/chemotaxis O88809 13193 X|X F2 mouse Y125-p 1833062501 ELEEGESyVCSSDNF DCX protein stabilization cytoskeletal reorganization 31914386 1 0 0 -Sphk1 SPHK1 ACETYLTRANSFERASE; Acetyltransferase; EC 2.3.1.-; EC 2.7.1.91; Kinase, lipid; Lipid Metabolism - sphingolipid Q8CI15 20698 11|11 E2 mouse S225-p 460682 VASKRPAsTLVQKGP intracellular localization; protein conformation; enzymatic activity, induced 19729605; 33865856 14 8 0 -Abcc9 ABCC9 Channel, potassium; Membrane protein, integral; Membrane protein, multi-pass; Transporter; Transporter, ABC family P70170 20928 6 G2|6 74.35 cM mouse S1465-p 483975 RAFVRKSsILIMDEA ABC_tran activity, induced 15087422 2 0 0 -FOXO3 FOXO3A Autophagy; DNA-binding; Oncoprotein; Transcription factor O43524 2309 6q21 human S253-p 449108 APRRRAVsMDNSNKY activity, induced; molecular association, regulation; intracellular localization; activity, inhibited; phosphorylation cell cycle regulation; carcinogenesis, induced; apoptosis, altered; carcinogenesis, inhibited; cell motility, induced; transcription, altered; autophagy, induced; cell growth, induced; apoptosis, inhibited; autophagy, inhibited; transcription, inhibited 14-3-3 beta(INDUCES); 14-3-3 zeta(INDUCES); 14-3-3 epsilon(INDUCES) 10102273; 11154281; 17079231; 18593906; 18794113; 20110348; 21777391; 21980390; 25745998; 26376801; 32005974; 34421352; 34475505; 35077510; 35874228 37 19 76 -PSRC1 PSRC1 Q6PGN9 84722 1p13.3 human S70-p 472052 RLSLGPLsPEKLEEI GTSE1_N cytoskeletal reorganization 21473853 1 21 10 -Pawr PAR-4 Apoptosis Q62627 64513 7q21 rat S249-p 456965 SRHNRDTsAPANFAS ATG16; DUF724; DUF4164 intracellular localization apoptosis, inhibited 16209943 1 0 0 phosphorylation by Akt prevents apoptosis -DAPK3 DAPK3 EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, CAMK; Protein kinase, Ser/Thr (non-receptor); Tumor suppressor O43293 1613 19p13.3 human T299-p 454893 PERRRLKtTRLKEYT intracellular localization 15611134; 20854903 3 0 0 -SRPK2 SRPK2 EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, CMGC; Protein kinase, Ser/Thr (non-receptor) P78362 6733 7q22.3 human T492-p 483237 PSHDRSRtVSASSTG molecular association, regulation; intracellular localization; enzymatic activity, induced cell cycle regulation; transcription, altered 14-3-3 beta(INDUCES); 14-3-3 epsilon(INDUCES) 19592491 3 6 0 nuclear translocation of SRPK2 is blocked by 14-3-3 -MAVS MAVS Adaptor/scaffold; Membrane protein, integral Q7Z434 57506 20p13 human K7-sc 33344549 _MPFAEDkTYKYICR CARD_2 activity, induced 32301534 1 2 0 cellular antiviral response -SLC39A7 SLC39A7 Membrane protein, integral; Membrane protein, multi-pass; Transporter; Transporter, SLC family Q92504 7922 6p21.32 human S293-p 18015864 VQKRRGGsTVPKDGP Zip activity, induced; phosphorylation exocytosis, induced; signaling pathway regulation 28205653 1 3 0 maximal activation, SLC39A7 and Akt activation, zinc release and downstream effectors GSK3B, and p70 S6, phosphorylation of multiple kinases -TBK1 TBK1 EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, Other; Protein kinase, Ser/Thr (non-receptor) Q9UHD2 29110 12q14.2 human R54-me 1881361501 RPVDVQMrEFEVLKK enzymatic activity, induced 34551290 1 0 0 TBK1 aggregation, PRMT1 positively regulates antiviral immune responses, and promotes cellular innate antiviral signaling -ESR1 ER-alpha DNA-binding; Nuclear receptor; Transcription factor P03372 2099 6q25.1-q25.2 human K180-sm 27992519 SMAMESAkETRYCAV Oest_recep transcription, inhibited 22826433 1 1 0 ER-alpha SUMOylation suppresses ER transcriptional activation by full antiestrogens (AEs) in the absence of induced ER degradation -WRN WRN Cell cycle regulation; DNA repair, damage; DNA-binding; EC 3.6.4.12; Helicase; Nucleolus Q14191 7486 8p12 human K1389-ac 486390 CSSSKRSkEEVGINT protein stabilization; ubiquitination 20428248 1 1 0 inhibits ubiquitination -PEBP1 RKIP Lipid-binding; Protein kinase, regulatory subunit P30086 5037 12q24.23 human S109-p 59070500 VLSDYVGsGPPKGTG PBP molecular association, regulation TBK1(INDUCES) 27753621 2 0 0 -PTGES3 TEBP Chaperone; EC 5.3.99.3; Isomerase; Nuclear receptor co-regulator; Transferase Q15185 10728 12q13.3|12 human S113-p 451129 WKDWEDDsDEDMSNF molecular association, regulation; enzymatic activity, induced HSP90A(INDUCES); CK2A1(INDUCES) 15040786 3 111 391 -CASR CaR GPCR, family 3; Membrane protein, integral; Membrane protein, multi-pass; Motility/polarity/chemotaxis; Receptor, GPCR P41180 846 3q13.33-q21.1 human S915-p 11488700 STPSSSIsSKSNSED activity, induced 9694886 1 0 0 -ETFB ETFB Mitochondrial; Oxidoreductase P38117 2109 19q13.41 human K203-m3 36974100 PNIMKAKkKKIEVIK ETF enzymatic activity, inhibited 25416781 2 2 0 inhibitory effect on the transfer of electrons -PAK2 PAK2 EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, STE; Protein kinase, Ser/Thr (non-receptor) Q13177 5062 3q29 human Y130-p 448301 VLDVLKFyDSNTVKQ PBD enzymatic activity, induced 12215529; 29987050 2 1 137 Y130F mutant failed to rescue PAK2 function-role in SFK-mediated phosphorylation -RBBP8 CtIP EC 3.1.-.-; Transcription, coactivator/corepressor Q99708 5932 18q11.2 human K426-ub 1883319600 QNRTEYGkDSNTDKH phosphorylation DNA repair, inhibited 36092721 1 1 0 suppresses HR and DNA resection, ubiquitylation is inhibited by phosphorylation by PLK1 -Ppp1r1b DARPP-32 Motility/polarity/chemotaxis; Protein phosphatase, regulatory subunit Q6J4I0 360616 10q31 rat S102-p 457675 NLSENQAsEEEDELG DARPP-32 protein conformation 8226946 8 13 23 PKA phosphorylation did not alter fluorescence parameters, and only minor effects were associated with casein kinase II -PCYT1A PCYT1A EC 2.7.7.15; Lipid Metabolism - glycerophospholipid; Transferase P49585 5130 3q29 human S362-p 451335 KAAAYDIsEDEED__ intracellular localization 32186954 3 49 57 -Ncor1 N-CoR1 Nuclear receptor co-regulator; Transcription, coactivator/corepressor Q60974 20185 11|11 B2 mouse K152-sm 3755600 KDPAFGVkHEAPSSP GPS2_interact transcription, inhibited 16421255 1 0 0 -CERT1 COL4A3BP EC 2.7.11.9; KINASE; Kinase, protein; Lipid-binding; Protein kinase, Ser/Thr (non-receptor); Protein kinase, atypical Q9Y5P4 10087 5q13.3 human S315-p 25174303 DYEEGPNsLINEEEF activity, induced; molecular association, regulation; intracellular localization chromatin organization, altered VAPA(INDUCES) 24569996; 35409383 2 2 0 enhances interaction, ER to Golgi transport of ceramide, punctate structures -NFKB1 NFkB-p105 iso2 DNA-binding; Transcription factor P19838-2 4790 4q24 human Y60-p 465351 QRGFRFRyVCEGPSH RHD_DNA_bind protein stabilization; molecular association, regulation transcription, altered DNA(INDUCES) 36534507 1 1 1 -TUBA1C TUBA1C Cytoskeletal; Motility/polarity/chemotaxis Q9BQE3 84790 12q13.12 human K40-ac 479499 DGQMPSDkTIGGGDD Tubulin cytoskeletal reorganization 23071314 1 2 15 -Nr3c1 GR DNA-binding; Mitochondrial; Nuclear receptor; Transcription factor P06536 24413 18p11 rat K721-sm 31089514 ELGKAIVkREGNSSQ Hormone_recep transcription, induced 23508108 1 1 0 -KLF5 KLF5 C2H2-type zinc finger protein; DNA-binding; Transcription factor Q13887 688 13q22.1 human S303-p 14652801 QATYFPPsPPSSEPG protein degradation; molecular association, regulation; ubiquitination carcinogenesis, altered; transcription, inhibited FBXW7(INDUCES) 20484041; 24398687 2 0 0 -PPP1R12A MYPT1 Motility/polarity/chemotaxis; PHOSPHATASE; Protein phosphatase, regulatory subunit O14974 4659 12q21.2-q21.31 human K442-m1 1872438900 TWRLGLRkTGSYGAL protein stabilization 21115810 1 0 0 -SOX10 SOX10 Cell development/differentiation; DNA-binding; Transcription factor P56693 6663 22q13.1 human T240-p 56655880 GQSHGPPtPPTTPKT sumoylation; protein stabilization; molecular association, regulation; activity, inhibited transcription, inhibited UBC9(DISRUPTS) 29295999; 29315345 2 3 0 pMITF expression; inhibits sumoylation -CERS6 LASS6 DNA-binding; Membrane protein, integral; Membrane protein, multi-pass Q6ZMG9 253782 2q24.3 human S345-p 22350306 DDRSDIEsSSDEEDS enzymatic activity, induced 26887952 1 3 0 -KIF2A KIF2A Microtubule-binding; Motor O00139 3796 5q12.1 human S135-p 4705535 SSAQQNGsVSDISPV intracellular localization; activity, inhibited cytoskeletal reorganization; cell motility, inhibited 26323690 1 5 0 decreases MT-binding and depolymerizing activity of KIF2A -HNRNPUL1 E1B-AP5 RNA splicing; RNA-binding Q9BUJ2 11100 19q13.2 human R620-m2 9481295 GGGGFRGrGGGGGFQ molecular association, regulation; intracellular localization NBS1(INDUCES) 26020839 1 3 1 ecruitment at sites of damage -Map2 MAP2 Cytoskeletal; Motility/polarity/chemotaxis P15146 25595 9q32 rat T1625-p 450182 RTPGTPGtPSYPRTP molecular association, regulation cytoskeletal reorganization 25309320 3 19 17 fractionated with microtubules, protrusion growth, regulates basal dendrite architecture in vivo -Klf4 KLF4 C2H2-type zinc finger protein; DNA-binding; Transcription factor Q60793 16600 4 B3|4 29.76 cM mouse R396-m2 1881871201 RRSWPRKrTATHTCD transcription, inhibited 35137179 1 1 0 restrain the PrE commitment in mouse blastocysts -GLI3 GLI3 C2H2-type zinc finger protein; Transcription factor P10071 2737 7p14.1 human S877-p 15501382 CFSSRRSsEASQAEG protein processing transcription, inhibited 10693759 1 0 3 -KIF23 KIF23 Microtubule-binding; Motility/polarity/chemotaxis; Motor Q02241 9493 15q23 human S911-p 459840 NGSRKRRsSTVAPAQ intracellular localization cytoskeletal reorganization 16461284; 23940115 5 18 267 -App APP iso2 Apoptosis; Cell surface; Membrane protein, integral; Receptor, misc.; Transcription factor P12023-2 11820 16 C3.3|16 46.92 cM mouse T668-p 448523 VEVDAAVtPEERHLS APP_amyloid molecular association, regulation; intracellular localization Fe65(DISRUPTS); PIN1(INDUCES); 14-3-3 gamma(DISRUPTS) 16223726; 16716194; 27325702 39 5 3 -CSNK2A1 CK2A1 EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, Other; Protein kinase, Ser/Thr (non-receptor) P68400 1457 20p13 human T13-p 31012808 PSRARVYtDVNTHRP transcription, induced 24297901 1 1 1 rRNA synthesis induced -Khdrbs1 KHDRBS1 RNA-binding Q60749 20218 4|4 D2.2 mouse S58-p 449876 PRGGARAsPATQPPP activity, induced translation, altered 12478298 1 14 0 regulates splicing -AGO2 AGO2 EC 3.1.26.n2; RNA processing; RNA-binding Q9UKV8 27161 8q24.3 human T830-p 62849200 DSAEGSHtSGQSNGR molecular association, regulation; activity, inhibited transcription, inhibited RNA(DISRUPTS) 28114302 2 2 0 regulates miRNA silencing -SKIL SKIL Cell development/differentiation; Transcription, coactivator/corepressor P12757 6498 3q26.2 human K449-ub 3144806 HSSGKLQkTVSYPDV protein degradation signaling pathway regulation 11691834 1 1 0 TGF-beta signaling -Slc23a2 SLC23A2 Membrane protein, integral; Membrane protein, multi-pass; Transporter; Transporter, SLC family Q9EPR4 54338 2|2 F2 mouse S403-p 483979 YYACARLsCAPPPPI Xan_ur_permease intracellular localization cell differentiation, altered 17585336 1 0 0 Phosphorylation is required for SLC3A2 localization in plasma membrane, and ascorbic acid uptake. -Pex5l PEX5L Unknown function Q925N3 286937 2q24 rat S237-p 481412 ALLSRNHsLEEEFER activity, induced; protein stabilization; molecular association, regulation; intracellular localization HCN1(INDUCES); CNBD1(INDUCES) 31492750 1 16 11 Regulates HCN channel function; interaction of PEX5L with HCN1-CNBD region -Kcnd2 Kv4.2 Channel, potassium; Membrane protein, integral; Membrane protein, multi-pass Q63881 rat S438-p 2906103 ARIRAAKsGSANAYM protein stabilization neural plasticity 15071113; 35625355 4 0 1 -LTF LTF EC 3.4.21.-; Protease; Secreted; Secreted, signal peptide P02788 4057 3p21.31 human S54-p 1883890600 KVRGPPVsCIKRDSP protein degradation transcription, induced 20404350 1 0 0 -SHC3 SHC3 iso2 Adaptor/scaffold; Motility/polarity/chemotaxis Q92529-2 53358 9q22.1 human Y219-p 451258 DGSDHPYyNSIPSKM molecular association, regulation CRK(INDUCES); RAPGEF1(INDUCES) 11791173 3 3 8 -DOCK6 DOCK6 GEF; GEF, misc.; Motility/polarity/chemotaxis Q96HP0 57572 19p13.2 human S1194-p 27806316 GQRSRLAsMLDSDTE enzymatic activity, inhibited cell growth, inhibited 23462102 1 2 0 -P2RY2 P2Y2 GPCR, family 1; Membrane protein, integral; Membrane protein, multi-pass; Receptor, GPCR; Receptor, misc. P41231 5029 11q13.4 human S356-p 2909202 IEDVLGSsEDSRRTE receptor desensitization, altered; intracellular localization 16311903 2 0 0 -TRAF2 TRAF2 Autophagy; EC 6.3.2.-; Ligase; UBIQUITIN LIGASE; Ubiquitin conjugating system; Ubiquitin ligase Q12933 7186 9q34.3 human S55-p 7378202 QCGHRYCsFCLASIL zf-C3HC4 apoptosis, inhibited; transcription, altered 19336568; 28726782 2 0 0 promotes NF-?B activation but suppresses c-Jun activation under H/R conditions; protects cells from stress-induced apoptosis -NPHS1 NPHS1 Cell adhesion; Immunoglobulin superfamily; Membrane protein, integral O60500 4868 19q13.12 human T1120-p 18507016 EYEESQWtGERDTQS molecular association, regulation ARRB2(INDUCES) 21321125 2 0 0 PICK1 and PKCa are also in this complex -Osbpl3 OSBPL3 iso3 Endoplasmic reticulum D3Z194 71720 6|6 B2.3 mouse T248-p 6209017 SMDVLHRtYSAPAIN apoptosis, inhibited 31509750 1 2 1 inhibits insulin secretion -KNG1 KNG1 Cell adhesion; Contractile; Inhibitor; Motility/polarity/chemotaxis; Secreted; Secreted, signal peptide P01042 3827 3q27.3 human S390-p 5024714 PGFSPFRsSRIGEIK protein processing 18844446 1 0 0 inhibits cleavage by kallikrein in vitro -SERPINA3 SERPINA3 Secreted; Secreted, signal peptide P01011 12 14q32.13 human K237-ac 464674 RFYLSKKkWVMVPMM Serpin molecular association, regulation DNA(INDUCES) 7782318 1 0 0 -Ripk3 RIPK3 EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, Ser/Thr (non-receptor); Protein kinase, TKL Q9QZL0 56532 14|14 C3 mouse K359-ub 1883588009 PSGPVPGkCPERQAQ apoptosis, inhibited 35800780 1 1 0 Loss of RIPK3-K359 ubiquitin modification prevents increased RIPK3-K469R killing activity, RIPK3-K469ub can restrict cell death by preventing upstream ubiquitylation on K359 -ATP4A ATP4A EC 3.6.3.10; Energy Metabolism - oxidative phosphorylation; Hydrolase; Membrane protein, integral; Membrane protein, multi-pass; Transporter; Transporter, ion channel P20648 495 19q13.12 human Y10-p 484290 KAENYELySVELGPG H-K_ATPase_N protein conformation 12480547 3 0 15 Structure indicates tyrosine sequential phosphorylation at Y10 and subsequent Y7 which may induce activation of ATP4A. -SF1 SF1 RNA splicing; RNA-binding; Spliceosome; Transcription, coactivator/corepressor Q15637 7536 11q13.1 human S82-p 452435 NPEDRSPsPEPIYNS SF1-HH molecular association, regulation RNA splicing, altered U2AF2(INDUCES) 16420481 1 88 12 facilitates formation of the SF1-U2AF-RNA complex -Twist1 TWIST1 Cell development/differentiation; DNA-binding; Inhibitor; Transcription regulation P26687 22160 12 A3|12 14.81 cM mouse T125-p 38546302 NVRERQRtQSLNEAF HLH carcinogenesis, induced; cell motility, induced; cell growth, induced 25622896; 32922123 4 0 0 -Gphn gephyrin Adaptor/scaffold; EC 2.10.1.1; EC 2.7.7.75 Q8BUV3 268566 12|12 C3 mouse S270-p 2020113 LSTTPSEsPRAQATS activity, induced; receptor internalization, induced; protein degradation; ubiquitination; intracellular localization neural plasticity 21173228; 31080408; 33878252; 35245123 10 23 2 induces GABAAR internalization -Rbm38 RBM38 RNA-binding Q62176 56190 2|2 H3 mouse S193-p 29606707 DQYPYAAsPAAATSF cell cycle regulation; carcinogenesis, induced; translation, induced 30567739; 33664057 7 0 0 regulates cellular senescence in a p53-dependent manner; induces p63 mRNA stability -CDK16 CDK16 Cell cycle regulation; EC 2.7.11.22; KINASE; Kinase, protein; Motility/polarity/chemotaxis; Protein kinase, CMGC; Protein kinase, Ser/Thr (non-receptor) Q00536 5127 Xp11.3 human S12-p 453448 KKIKRQLsMTLRGGR exocytosis, inhibited 22798068 2 18 12 BRSK2 phosphorylation inhibited insulin secretion at 25 mM glucose. -Junb JunB Motility/polarity/chemotaxis; Oncoprotein; Transcription factor P24898 24517 19q11 rat T150-p 1814004 LHKMNHVtPPNVSLG Jun protein degradation cell cycle regulation; transcription, altered 10790372 1 0 0 Phosphorylation promoted degradation during the G2-M transition. JunB inhibition of cyclin D1 transcription is relieved by JunB protein degradation. -Mknk2 Mnk2 EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, CAMK; Protein kinase, Ser/Thr (non-receptor); Translation Q8CDB0 17347 10|10 C1 mouse T244-p 447640 GDCSPIStPELLTPC Pkinase enzymatic activity, induced 11154262 1 1 0 -GJA1 GJA1 Channel, misc.; Membrane protein, integral; Membrane protein, multi-pass; Motility/polarity/chemotaxis Q6TYA7 rabbit S369-p 459208 RPSSRASsRASSRPR intracellular localization 18574580 15 8 2 ischemia induces changes in the pattern of the Cx43 membrane distribution -Irs1 IRS1 Adaptor/scaffold; Motility/polarity/chemotaxis P35570 25467 9q34 rat Y939-p 448700 EETGSEEyMNMDLGP molecular association, regulation PIK3R1(INDUCES) 7504175 3 5 47 -AREL1 AREL1 iso2 Membrane protein, integral; UBIQUITIN LIGASE; Ubiquitin conjugating system; Ubiquitin ligase O15033-2 9870 14q24.3 human T783-p 56589716 IAAPTHStLPTAHT_ HECT protein degradation; molecular association, regulation AREL1 iso2(INDUCES) 27162139 1 0 0 -Cish CISH Q62225 12700 9 F1|9 57.99 cM mouse Y253-p 62887803 MADYLRQyPFQL___ cell growth, inhibited 28038963 1 0 0 -HMGN1 HMGN1 DNA-binding; Nuclear receptor co-regulator P05114 3150 21q22.2 human K59-ac 458852 TKGKRGAkGKQAEVA HMG14_17 molecular association, regulation DNA(DISRUPTS) 10753971 1 1 0 -GMNN Geminin Cell cycle regulation; Motility/polarity/chemotaxis O75496 51053 6p22.3 human T25-p 40323301 NSSVPRRtLKMIQPS Geminin protein stabilization 23695679 1 0 0 -AKT1 Akt1 EC 2.7.11.1; KINASE; Kinase, protein; Oncoprotein; Protein kinase, AGC; Protein kinase, Ser/Thr (non-receptor) P31749 207 14q32.33 human T92-p 22776839 ERTFHVEtPEEREEW PH protein stabilization; molecular association, regulation; protein conformation; phosphorylation PIN1(INDUCES) 19448664 1 0 3 sites can increase Akt activation slightly and maintain activation and stability -YES1 Yes EC 2.7.10.2; KINASE; Kinase, protein; Oncoprotein; Protein kinase, TK; Protein kinase, tyrosine (non-receptor) P07947 7525 18p11.32 human Y426-p 447619 RLIEDNEyTARQGAK PK_Tyr_Ser-Thr phosphorylation; enzymatic activity, induced carcinogenesis, induced; cell motility, induced 33941853 7 93 3048 induces phosphorylation of ANXA2 -Cebpb C/EBP-beta DNA-binding; Motility/polarity/chemotaxis; Transcription factor P21272 24253 3q42 rat S185-p 455886 LSTSSSSsPPGTPSP transcription, altered DNA(INDUCES) 16055922 8 9 9 -USP28 USP28 DEUBIQUITINASE; EC 3.4.19.12; Protease; Ubiquitin-specific protease Q96RU2 57646 11q23.2 human K99-sm 36692602 IDLTHDNkDDLQAAI enzymatic activity, inhibited 25359778 1 1 0 -Gja1 GJA1 Channel, misc.; Membrane protein, integral; Membrane protein, multi-pass; Motility/polarity/chemotaxis P08050 24392 20q11 rat S262-p 450694 SPSKDCGsPKYAYFN cell cycle regulation; cell growth, induced; signaling pathway regulation; cell growth, altered 14702389; 23882217 29 5 4 -TXNIP TXNIP Apoptosis; Mitochondrial; Motility/polarity/chemotaxis; Tumor suppressor Q9H3M7 10628 1q21.1 human S361-p 3212304 DMDGSQDsPIFMYAP molecular association, regulation; intracellular localization cell cycle regulation COPS5(INDUCES) 30410860 1 4 5 important for p27-Kip1 stabilization by TXNIP -GPR15 GPR15 GPCR, family 1; Membrane protein, integral; Membrane protein, multi-pass; Receptor, GPCR P49685 2838 3q11.2 human S357-p 125971702 FARRRKRsVSL____ endocytosis, induced 28615320 1 0 0 -IKBKB IKKB EC 2.7.11.10; KINASE; Kinase, protein; Protein kinase, Other; Protein kinase, Ser/Thr (non-receptor) O14920 3551 8p11.21 human S733-p 5014908 TVREQDQsFTALDWS IKKbetaNEMObind molecular association, regulation; phosphorylation cell differentiation, inhibited; transcription, inhibited IKKG(DISRUPTS) 18957422; 35966593 2 2 0 -Traf6 TRAF6 EC 6.3.2.-; Ligase; UBIQUITIN LIGASE; Ubiquitin conjugating system; Ubiquitin ligase P70196 22034 2|2 E2 mouse S47-p 1040254703 ASTGNLSsSFMEEIQ ubiquitination 29563609 1 0 0 colon epithelia in?ammation -KIT Kit EC 2.7.10.1; KINASE; Kinase, protein; Membrane protein, integral; Oncoprotein; Protein kinase, TK; Protein kinase, tyrosine (receptor) P10721 3815 4q12 human Y823-p 448018 DIKNDSNyVVKGNAR PK_Tyr_Ser-Thr protein stabilization; receptor internalization, inhibited; phosphorylation cell growth, induced; apoptosis, inhibited; signaling pathway regulation 23803604 3 3 11 increased posphorylation of an adaptor protein Cbl -NFATC1 NFAT2 DNA-binding; Transcription factor O95644 4772 18q23 human S278-p 41453273 NGRQPPYsPHHSPTP activity, induced; protein stabilization carcinogenesis, induced; cell motility, induced; transcription, induced 28235034; 31730483 2 3 0 multiple sites mutatnt -IFIH1 MDA5 Apoptosis; EC 3.6.4.13; Helicase Q9BYX4 64135 2q24.2 human S828-p 40587800 GRARADEsTYVLVAH protein conformation transcription, inhibited 25865883 1 0 0 disrupts MDA5 multimer formation -SP1 SP1 C2H2-type zinc finger protein; DNA-binding; Transcription factor P08047 6667 12q13.13 human S702-p 5262508 FMRSDHLsKHIKTHQ zf-C2H2 molecular association, regulation transcription, induced HDAC1(DISRUPTS) 27320013 2 2 0 SCARB1 gene expression -VIM Vimentin Cytoskeletal; Motility/polarity/chemotaxis P08670 7431 10p13 human S56-p 451514 SRSLYASsPGGVYAT Filament_head activity, induced; molecular association, regulation; intracellular localization; phosphorylation carcinogenesis, induced; endocytosis, induced; cell motility, induced; exocytosis, induced; cytoskeletal reorganization; transcription, altered Vimentin(DISRUPTS); Cas-L(DISRUPTS); SERT(INDUCES); CDK1(INDUCES) 16990256; 16997882; 19270731; 21465480; 26369929; 27603133; 30267961; 31931758; 33525953; 36231009 32 85 227 -Notch2 Notch 2 KINASE; Kinase, protein; Membrane protein, integral; Motility/polarity/chemotaxis; Receptor, misc. Q9QW30 29492 2q34 rat S2078-p 450165 PPGTVLTsALSPVLC activity, induced cell differentiation, altered 11577080 1 1 0 -Ndel1 NDEL1 Microtubule-binding; Protease Q9ERR1 83431 11|11 B3 mouse S336-p 1869686801 LGSSRPSsAPGMLPL phosphorylation cell growth, induced; cell differentiation, induced; cytoskeletal reorganization 31815665 1 1 0 neuronal dendrite outgrowth and arborization; primes phosphorylation of S332 by GSK3beta -Rap1gap RAP1GAP GAP; GAP, Ras; Motility/polarity/chemotaxis XP_233609 313644 5q36 rat S530-p 3190708 PFGSRRSsAIGIENI cytoskeletal reorganization 19218462 4 25 25 controls dendritic spine morphology -Gabrg2 GABRG2 Channel, chloride; Channel, ligand-gated; Membrane protein, integral; Membrane protein, multi-pass; Transporter; Transporter, ion channel P22723 14406 11 A5|11 24.8 cM mouse S329-p 1869465807 RKSLPKVsYVTAMDL Neur_chan_memb intracellular localization neural plasticity; signaling pathway regulation 31618635 1 0 0 Nogo-A signaling -HMGB1 HMGB1 DNA repair, damage; Nuclear receptor co-regulator P09429 3146 13q12.3 human K12-ac 459197 DPKKPRGkMSSYAFF HMG_box_2 molecular association, regulation DNA(INDUCES) 18241198 3 5 20 -HTT Huntingtin Cytoskeletal P42858 3064 4p16.3 human K15-sm 8545505 MKAFESLkSFQQQQQ protein stabilization; intracellular localization transcription, inhibited 15064418 2 0 0 -Irf6 IRF6 DNA-binding; Transcription factor P97431 54139 1 H6|1 97.6 cM mouse S413-p 18911095 FSGDFTRsFDSGSVR phosphorylation 31578523 3 3 0 stimulates phosphorylation of S90 -RPS3 RPS3 Apoptosis; EC 4.2.99.18; RNA-binding; Ribosomal; Translation P23396 6188 11q13.4 human K214-ub 486643 HVSIVEPkDEILPTT protein degradation; ubiquitination; intracellular localization cell growth, inhibited; signaling pathway regulation 35951361; 36567344 3 12 139 inhibits NF-kB translocation into the nucleus, and disrupts NF-kB signaling pathway, inhibits proliferation and metastasis -Kcnma1 KCNMA1 iso4 Channel, potassium; Endoplasmic reticulum; Membrane protein, integral; Membrane protein, multi-pass Q08460-4 16531 14|14 A3 mouse S722-p 18264900 GRSERDCsCMSGRVR activity, induced 21209098 1 0 0 abolishes inhibition resulting from AMPK phosphorylation (of another site, presumably) -Erbb3 HER3 EC 2.7.10.1; KINASE; Kinase, protein; Membrane protein, integral; Oncoprotein; Protein kinase, TK; Protein kinase, tyrosine (receptor) Q62799 29496 7q11 rat Y1286-p 449858 CPAAEQGyEEMRAFQ molecular association, regulation; phosphorylation PIK3CB(INDUCES); PIK3R1(INDUCES) 11546794 30 10 125 induces phosphorylation of Akt1. -NEDD8 NEDD8 Ubiquitin-like modifier Q15843 4738 14q12 human K33-ac 1878097300 IKERVEEkEGIPPQQ molecular association, regulation PARP1(INDUCES) 30804002 1 1 0 -CDC37 CDC37 Chaperone Q16543 11140 19p13.2 human S339-p 62877802 HMQRCIDsGLWVPNS CDC37_C molecular association, regulation CDK4(DISRUPTS); AurB(DISRUPTS); Src(DISRUPTS) 28073914 1 1 0 -Rps6kb1 p70S6K iso2 EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, AGC; Protein kinase, Ser/Thr (non-receptor); Translation P67999-2 83840 10q26 rat T389-p 448607 NQVFLGFtYVAPSVL Pkinase_C protein degradation; enzymatic activity, induced 24961241 476 9 1 degradation of IRS1/2 -Cdkn1b p27Kip1 Cell cycle regulation; Inhibitor; Oncoprotein; Protein kinase, regulatory subunit P46414 12576 6 G1|6 65.77 cM mouse T170-p 6058800 QNKRANRtEENVSDG intracellular localization 18701472 2 0 0 Cytoplasmic p27 is unable to inhibit Cdk2 kinase activity. -CDC20 CDC20 Cell cycle regulation; Ubiquitin conjugating system Q12834 991 1p34.2 human T59-p 23092103 AGRTPGRtPGKSSSK cell cycle regulation 33819340 1 2 3 -BRAF BRAF EC 2.7.11.1; KINASE; Kinase, protein; Oncoprotein; Protein kinase, Ser/Thr (non-receptor); Protein kinase, TKL P15056 673 7q34 human T401-p 452246 STTGLSAtPPASLPG molecular association, regulation; enzymatic activity, inhibited cell growth, altered RAF1(DISRUPTS) 19933846; 21135229 3 25 10 -RRP1B RRP1B Nucleolus; RNA-binding; Ribosomal; Translation Q14684 23076 21q22.3 human S702-p 3196466 EFKKTDKsILVSPTG molecular association, regulation PPP1CC(DISRUPTS); PPP1CA(DISRUPTS) 36450254 1 10 0 -DPYSL2 CRMP-2 iso3 Microtubule-binding; Motility/polarity/chemotaxis NP_001184222 1808 8p21.2 human S623-p 448081 KTVTPASsAKTSPAK carcinogenesis, altered; cell motility, altered 24036111 9 33 17 -ITPKA ITPKA Carbohydrate Metabolism - inositol phosphate; EC 2.7.1.127; Kinase, lipid; Motility/polarity/chemotaxis P23677 3706 15q15.1 human T311-p 451074 EHAQRAVtKPRYMQW IPK enzymatic activity, induced 9155020 1 0 0 -Rreb1 RREB1 C2H2-type zinc finger protein; DNA-binding; Motility/polarity/chemotaxis; Nuclear receptor co-regulator; Transcription, coactivator/corepressor Q3UH06 68750 13|13 A3.3 mouse S970-p 4719142 AGQAEPLsPRPPPCP molecular association, regulation transcription, induced DNA(INDUCES) 31915377 1 5 0 -Bax BAX Apoptosis; Membrane protein, integral; Mitochondrial; Tumor suppressor Q07813 12028 7 B3|7 29.32 cM mouse S184-p 451017 VAGVLTAsLTIWKKM TM molecular association, regulation; intracellular localization apoptosis, inhibited MCL1(INDUCES); Bcl-xL(INDUCES) 14766748 9 0 0 -Nf2 Merlin Cytoskeletal; Motility/polarity/chemotaxis; Tumor suppressor Q63648 25744 14q21 rat S514-p 448282 DTDMKRLsMEIEKEK ERM_C cell growth, altered 16885985 33 41 1 -ADRA2A ADRA2A GPCR, family 1; Membrane protein, integral; Membrane protein, multi-pass; Receptor, GPCR P08913 150 10q25.2 human S311-p 456349 DALDLEEsSSSDHAE 7tm_1 activity, inhibited 7876239 1 2 0 -NEDD4L NEDD4L EC 6.3.2.-; EC 6.3.2.19; Ligase; UBIQUITIN LIGASE; Ubiquitin conjugating system; Ubiquitin ligase Q96PU5 23327 18q21.31 human S342-p 453438 SSRLRSCsVTDAVAE activity, induced; protein stabilization; molecular association, regulation; ubiquitination; protein conformation; activity, inhibited; phosphorylation signaling pathway regulation 14-3-3 sigma(INDUCES); NHE3(INDUCES); ENaC-beta(DISRUPTS); NKCC2(DISRUPTS); ENaC-alpha(INDUCES); SMAD3(DISRUPTS) 11742982; 15328345; 17715136; 19917253; 21852580; 24657276; 34294877; 34823064 14 17 59 inhibits NCC ubiquitination, SGK1-Nedd4-2 Pathway -NDUFB6 NDUFB6 EC 1.6.5.3; EC 1.6.99.3; Energy Metabolism - oxidative phosphorylation; Membrane protein, integral; Mitochondrial; Oxidoreductase O95139 4712 9p21.1 human S29-p 23253630 WLKDQELsPREPVLP NDUF_B6 activity, induced cell cycle regulation 24746669 1 3 1 increases mitochondrial respiration for G/2M transition -KCNJ1 ROMK Channel, potassium; Membrane protein, integral; Membrane protein, multi-pass P48048 3758 11q24.3 human S313-p 2461200 ATCQVRTsYVPEEVL IRK_C activity, induced; protein conformation; activity, inhibited 18547545; 18571730; 18620882 5 0 0 -PELI1 PELI1 Adaptor/scaffold; EC 6.3.2.-; EC 6.3.2.19; Ligase; UBIQUITIN LIGASE; Ubiquitin conjugating system; Ubiquitin ligase Q96FA3 57162 2p14 human T80-p 7388010 DQHSISYtLSRAQTV Pellino ubiquitination; enzymatic activity, induced 19264966 2 0 0 -Crhr1 CRF-R1 GPCR, family 2; Membrane protein, integral; Membrane protein, multi-pass; Receptor, GPCR P35347 12921 11 E1|11 67.77 cM mouse T413-p 25288088 FHSIKQStAV_____ molecular association, regulation PSD-95(INDUCES) 26352593 1 0 1 -MAFA MAFA DNA-binding; Oncoprotein; Transcription factor; Tumor suppressor O57342 quail T57-p 456028 LSSTPLStPCSSVPS cell differentiation, altered; transcription, altered 15963504 8 1 0 -DBN1 DBN1 iso3 Actin-binding; Cytoskeletal; Motility/polarity/chemotaxis Q16643-3 1627 5q35.3 human S647-p 472365 SEGYFSQsQEEEFAQ protein stabilization neural plasticity; cytoskeletal reorganization 30700723 2 16 14 -TH TH iso4 Amino Acid Metabolism - tyrosine; EC 1.14.16.2; Endoplasmic reticulum; Mitochondrial; Oxidoreductase; Vesicle P07101-4 7054 11p15.5 human S35-p 448544 AIMVRGQsPRFIGRR TOH_N enzymatic activity, induced 7901013 43 8 0 -ERG ERG DNA-binding; Oncoprotein; Transcription factor P11308 2078 21q22.2 human S81-p 4712347 QVNGSRNsPDECSVA transcription, induced 23918819 1 8 0 -NUP153 NUP153 Nuclear export; Nucleoporin P49790 9972 6p22.3 human T388-p 3191107 VYFKPSLtPSGEFRK Nup153 molecular association, regulation KPNB1(DISRUPTS) 19767751 1 9 4 -POLM POLM DNA repair, damage; EC 2.7.7.7; Transferase Q9NP87 27434 7p13 human T21-p 469478 SGDAASStPPSTRFP molecular association, regulation; enzymatic activity, inhibited DNA(DISRUPTS) 23933132 1 1 3 -FYB1 SLAP-130 Adaptor/scaffold O15117 2533 5p13.1 human Y651-p 452095 LDMGDEVyDDVDTSD molecular association, regulation cell adhesion, induced; cell motility, altered; cell adhesion, altered SLP76(INDUCES); NCK1(INDUCES); NCK2(INDUCES) 10570256; 20661443; 23979596; 24769494 5 4 13 -Ulk1 ULK1 Autophagy; EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, Other; Protein kinase, Ser/Thr (non-receptor) O70405 22241 5|5 F mouse S1047-p 10428800 RRLSALLsGVYA___ DUF3543 signaling pathway regulation 21855797 2 2 0 Hsp90-Cdc37-to-Ulk1-to-Atg13 pathway -Ncoa3 SRC-3 ACETYLTRANSFERASE; Acetyltransferase; EC 2.3.1.48; Motility/polarity/chemotaxis; Nuclear receptor co-regulator; Transcription, coactivator/corepressor O09000 17979 2|2 H3 mouse S850-p 454106 NRAVSLDsPVSVGSG carcinogenesis, inhibited; cell growth, inhibited; cell differentiation, induced; transcription, inhibited; signaling pathway regulation 20534466 7 16 0 inhibits insulin/IGF1 signaling -H2ac4 H2A.1 DNA-binding C0HKE1 319172 13|13 A3.1 mouse R88-m1 7836401 RHLQLAIrNDEELNK Histone chromatin organization, altered 19434510 0 2 0 regulation of senescence-related epigenetics modification -CDC42 CDC42 G protein; G protein, monomeric; G protein, monomeric, Rho; Motility/polarity/chemotaxis G1SYB4 rabbit S77-p 28716002 YDRLRPLsYPQTDVF Ras activity, induced; intracellular localization cell motility, induced 23833064 3 0 0 -ATF2 ATF-2 ACETYLTRANSFERASE; C2H2-type zinc finger protein; EC 2.3.1.48; Transcription factor P15336 1386 2q31.1 human T69-p 448224 SVIVADQtPTPTRFL activity, induced; protein degradation; protein stabilization; ubiquitination; enzymatic activity, induced cell cycle regulation; cell motility, induced; transcription, induced; transcription, altered; signaling pathway regulation 10777545; 10821277; 11313929; 12110590; 21098032; 21858082; 33893075; 7737129; 7737130; 7824938 32 57 50 -NCOR2 SMRT Nuclear receptor co-regulator; Transcription, coactivator/corepressor Q9Y618 9612 12q24.31 human S2511-p 465590 CSQYETLsDSE____ molecular association, regulation TR-alpha(INDUCES) 11451368 1 8 1 phosphorylation stabilizes SMRT interaction with TR-alpha in vitro -Drgx DRGX DNA-binding Q8BYH0 107751 14|14 B mouse S233-p 62925704 LLPSTSSsPGPASKQ protein conformation transcription, altered 28049756 1 1 0 -RND3 RhoE G protein; G protein, monomeric; G protein, monomeric, Rho; Motility/polarity/chemotaxis P61587 390 2q23.3 human S210-p 27933600 KNVKRNKsQRATKRI molecular association, regulation; intracellular localization cell cycle regulation; cytoskeletal reorganization 14-3-3 beta(INDUCES); GRF-1(DISRUPTS) 23622247; 32041905 2 0 0 -DISC1 DISC1 Cell development/differentiation; Motility/polarity/chemotaxis Q9NRI5 27185 1q42.2 human S58-p 18942701 GPGIGFLsPAVGTLF molecular association, regulation; intracellular localization transcription, induced ATF-4(DISRUPTS) 23587879 2 1 0 S58-p is localized in the cytoplasm, dephosphorylated is nuclear localized. ATF-4 DISC1 binding region acts as a transcriptional repressor to the PDE4D9 promoter. -DNMT1 DNMT1 Amino Acid Metabolism - cysteine and methionine; Cell development/differentiation; EC 2.1.1.37; METHYLTRANSFERASE; Methyltransferase; Methyltransferase, DNA; Transcription regulation P26358 1786 19p13.2 human K194-sm 12726303 AKSDESIkEEDKDQD enzymatic activity, induced DNA(INDUCES) 19450230 1 0 0 -PXN PXN Adaptor/scaffold; Cell adhesion; Cytoskeletal; Motility/polarity/chemotaxis P49024 395832 chicken Y118-p 448604 ASEEEHVySFPNKQK Paxillin molecular association, regulation cytoskeletal reorganization CDK6(INDUCES) 12949231 83 79 2519 -KRT8 K8 Cytoskeletal P05787 3856 12q13.13 human K11-ac 461564 RVTQKSYkVSTSGPR Keratin_2_head cytoskeletal reorganization 18203277; 18983182 2 2 14 -Mapk3 ERK1 EC 2.7.11.24; KINASE; Kinase, protein; Protein kinase, CMGC; Protein kinase, Ser/Thr (non-receptor) P21708 50689 1q36 rat Y205-p 447543 HTGFLTEyVATRWYR Pkinase activity, induced; intracellular localization; enzymatic activity, induced translation, altered; cell adhesion, induced; signaling pathway regulation; cell growth, altered 10473611; 11731096; 12163549; 14627993; 15757502; 16368189; 19427337; 19943942; 20096547; 21357465; 21738764; 21917714; 22076135; 34475824; 8387499 1366 142 3549 -BDKRB2 BKR2 GPCR, family 1; Membrane protein, integral; Membrane protein, multi-pass; Receptor, GPCR P30411 624 14q32.2 human Y347-p 452100 RKKSWEVyQGVCQKG activity, induced; phosphorylation 16226010 3 2 0 this increases ERK activation when stimulated with EGF+isoproterenol+bradykinin as compared to the WT BKR2.; Mutation of both tyrosines to phenylalanines prevents Gi protein-mediated cAMP accumulation induced by bradykinin -CERT1 COL4A3BP EC 2.7.11.9; KINASE; Kinase, protein; Lipid-binding; Protein kinase, Ser/Thr (non-receptor); Protein kinase, atypical Q9Y5P4 10087 5q13.3 human S149-p 4777489 GYSATSTsSFKKGHS molecular association, regulation; activity, inhibited 28652409 0 1 0 reduced PtdIns(4)P binding affinity as well as low ceramide transfer activity, E494R/N495K/P535R/E537K mutations, recovery of both PtdIns(4)P binding and ceramide transfer activity. -Nr5a1 STF-1 Nuclear receptor; Transcription, coactivator/corepressor P33242 26423 2 B|2 24.42 cM mouse K119-sm 2798301 QIRANGFkLETGPPM molecular association, regulation transcription, altered; signaling pathway regulation; transcription, inhibited GEMIN3(INDUCES) DNA(DISRUPTS) 15713642; 18838537; 21820362 7 0 0 affects hedgehog signaling -RALGAPA2 RALGAPA2 GAP; GAP, Ras Q2PPJ7 57186 20p11.23 human T715-p 460565 PMRFRSAtTSGAPGV molecular association, regulation carcinogenesis, induced; signaling pathway regulation 14-3-3 theta(INDUCES) 22580611; 23386617 2 7 54 cell invasion induced -GIT1 GIT1 GAP; GAP, ARF; Motility/polarity/chemotaxis Q9Y2X7 28964 17q11.2 human Y284-p 15702201 EELAMDVyDEVDRRE GIT_SHD molecular association, regulation; protein conformation; activity, inhibited cell motility, induced PXN(INDUCES) 24699139 4 1 0 -CTNNB1 CTNNB1 Actin-binding; Cell adhesion; Motility/polarity/chemotaxis; Nuclear receptor co-regulator; Oncoprotein; Transcription factor P35222 1499 3p22.1 human T120-p 6406005 QFDAAHPtNVQRLAE protein degradation; molecular association, regulation; intracellular localization cell growth, inhibited; transcription, induced; cell motility, inhibited; transcription, altered; transcription, inhibited CTNNA1(INDUCES) 19141652; 22511927; 24240237; 29108267 6 0 0 cytoplasmic localization, PrKD1 promoter activity, lower AR transcriptional activity -PAK1 PAK1 EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, STE; Protein kinase, Ser/Thr (non-receptor) Q13153 5058 11q13.5-q14.1 human K148-ub 56714905 KYMSFTDkSAEDYNS protein degradation 27302166 1 0 0 -GJA1 GJA1 Channel, misc.; Membrane protein, integral; Membrane protein, multi-pass; Motility/polarity/chemotaxis P17302 2697 6q22.31 human S255-p 448852 HATSGALsPAKDCGS molecular association, regulation; intracellular localization; activity, inhibited; protein conformation endocytosis, induced; cell growth, inhibited FLNB(DISRUPTS); CLTA(INDUCES) 15605363; 22737133; 23828237; 24492000; 26161412; 36164986 23 21 1 -Sgk1 SGK1 EC 2.7.11.1; KINASE; Kinase, protein; Motility/polarity/chemotaxis; Protein kinase, AGC; Protein kinase, Ser/Thr (non-receptor) Q06226 29517 1p12 rat T256-p 448431 EHNGTTStFCGTPEY Pkinase enzymatic activity, induced 10357815 15 0 0 -ID2 ID2 DNA-binding; Transcription, coactivator/corepressor Q02363 3398 2p25.1 human T27-p 4706880 LGISRSKtPVDDPMS protein stabilization cell growth, inhibited 26756672 3 2 0 -CDC42BPA MRCKA EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, AGC; Protein kinase, Ser/Thr (non-receptor) Q5VT25 8476 1q42.13 human T403-p 12612503 HLPFVGFtYTSSCVL Pkinase_C enzymatic activity, induced cytoskeletal reorganization 11283256 1 0 0 -EPAS1 HIF2A DNA-binding; Transcription factor Q99814 2034 2p21 human T324-p 471073 VWLETQGtVIYNPRN PAS_3 molecular association, regulation apoptosis, induced; transcription, altered SP1(DISRUPTS) 17024177 1 0 0 -ACLY ACLY Carbohydrate Metabolism - citrate (TCA) cycle; EC 2.3.3.8; Lyase; Transferase P53396 47 17q21.2 human Y682-p 450360 SRTTDGVyEGVAIGG Ligase_CoA acetylation; enzymatic activity, induced carcinogenesis, induced 32420483 1 23 363 -Mip AQP0 Channel, misc.; Membrane protein, integral; Membrane protein, multi-pass; Transporter, aquaporin family P09011 25480 7q11 rat S233-p 450116 KSVSERLsILKGARP molecular association, regulation; intracellular localization 18523655; 22194645 6 9 0 No differences in the interaction with filensin between the AQP0 COOH-terminal peptide and its pseudophosphorylated proteins -Myocd myocardin Cell development/differentiation; Transcription factor Q8VIM5 214384 11|11 B3 mouse S458-p 3627512 HFGSTSSsPPISPAS transcription, inhibited 16141410 1 0 0 -MAF MAF Cell development/differentiation; DNA-binding; Oncoprotein; Transcription factor; Tumor suppressor O75444 4094 16q23.2 human Y92-p 25673105 KAHLEDYyWMTGYPQ Maf_N activity, induced; molecular association, regulation transcription, induced DNA(INDUCES) 22798672 2 0 0 Interacts with IL-4 promoter and transactivates IL-4 -ATF2 ATF-2 ACETYLTRANSFERASE; C2H2-type zinc finger protein; EC 2.3.1.48; Transcription factor P15336 1386 2q31.1 human T71-p 448225 IVADQTPtPTRFLKN activity, induced; protein degradation; protein stabilization; ubiquitination; enzymatic activity, induced cell cycle regulation; cell motility, induced; transcription, induced; transcription, altered; signaling pathway regulation; cell growth, altered 10777545; 10821277; 11313929; 12110590; 12208955; 21098032; 21858082; 21878628; 33893075; 7737129; 7737130; 7824938 53 54 37 -Fgf2 FGF2 Activator; Motility/polarity/chemotaxis P15655 14173 3 B|3 18.41 cM mouse Y81-p 13823202 KGVCANRyLAMKEDG FGF intracellular localization 20230531 2 1 0 essential for FGF2 secretion -PPARG PPAR-gamma iso3 DNA-binding; Nuclear receptor; Transcription factor P37231-3 5468 3p25.2 human S84-p 448062 AIKVEPAsPPYYSEK cell cycle regulation; cell growth, induced; transcription, inhibited 24440556 33 7 0 Cell growth is regulated by cell cycle arrest. -STK4 MST1 Autophagy; EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, STE; Protein kinase, Ser/Thr (non-receptor) Q13043 6789 20q13.12 human T183-p 447925 DTMAKRNtVIGTPFW Pkinase activity, induced; molecular association, regulation; intracellular localization; phosphorylation; enzymatic activity, induced cell cycle regulation; carcinogenesis, inhibited; cell growth, inhibited; apoptosis, induced; cell motility, inhibited; transcription, inhibited; signaling pathway regulation GJA1(INDUCES); MOBKL2A(INDUCES) 11805089; 22619175; 24362629; 24872389; 30903103; 31679687; 35804016; 36115593; 36164986; 36622276; 37319316 25 2 5 -Clip1 Restin Cytoskeletal Q9JK25 65201 12q16 rat S309-p 4769827 TPASLKRsPSASSLS molecular association, regulation; protein conformation TUBA1C(DISRUPTS) 20519438 1 11 1 -NHERF1 NHERF Adaptor/scaffold; Motility/polarity/chemotaxis O14745 9368 17q25.1 human S340-p 455753 RAHQKRSsKRAPQMD EBP50_C molecular association, regulation CFTR(INDUCES); Ezrin(DISRUPTS) 17613530; 35140182 5 1 12 -Hcls1 HS1 Adaptor/scaffold; Motility/polarity/chemotaxis P49710 15163 16|16 B3 mouse Y405-p 451636 DEDAEGDyEDVLEPE molecular association, regulation; intracellular localization ITK(INDUCES) 15166239; 19917685 9 1 7 -KRT8 K8 Cytoskeletal P05787 3856 12q13.13 human S291-p 3081700 IKYEELQsLAGKHGD Filament protein conformation 11850543 1 8 5 Conformational change in K8 gene intermediate filaments. -NF2 Merlin Cytoskeletal; Motility/polarity/chemotaxis; Tumor suppressor P35240 4771 22q12.2 human S315-p 487469 MRRRKADsLEVQQMK FERM_C protein degradation; molecular association, regulation; phosphorylation carcinogenesis, induced; cell motility, induced; cell growth, induced CD44(DISRUPTS) 17891137; 21750658 4 6 0 induces phosphorylation at S518 -NAT1 NAT1 ACETYLTRANSFERASE; Acetyltransferase; EC 2.3.1.5; Secondary Metabolites Metabolism - caffeine; Xenobiotic Metabolism - drug metabolism - other enzymes P18440 9 8p22 human K188-ac 36302509 LEDSKYRkIYSFTLK Acetyltransf_2 molecular association, regulation; enzymatic activity, inhibited PPAT(DISRUPTS) 32487734 1 1 0 acetylation inhibited the allosteric effects of ATP on NAT1 -RYR2 RYR2 Channel, ligand-gated; Membrane protein, integral; Membrane protein, multi-pass; Transporter; Transporter, ion channel Q92736 6262 1q43 human S2814-p 458801 ISQTSQVsVDAAHGY activity, induced signaling pathway regulation 22304913; 29760186; 30571258 63 8 5 induces CAMKKB-AMPK pathway; release of Ca2+ in KI cardiomycetes; increased leak load relationship, enhanced Ca buffering and regulates Ca handling -EGFR EGFR EC 2.7.10.1; KINASE; Kinase, protein; Membrane protein, integral; Oncoprotein; Protein kinase, TK; Protein kinase, tyrosine (receptor) P00533 1956 7p11.2 human S1070-p 448051 DSFLQRYsSDPTGAL receptor desensitization, altered; receptor internalization, altered 1309762; 7505275 17 6 7 -Lats2 LATS2 EC 2.7.11.1; KINASE; Kinase, protein; Nuclear receptor co-regulator; Protein kinase, AGC; Protein kinase, Ser/Thr (non-receptor); Tumor suppressor Q7TSJ6 50523 14|14 C3 mouse S830-p 10945601 HQRCLAHsLVGTPNY Pkinase enzymatic activity, induced cell growth, altered 12853976 5 3 15 -EIF2AK3 PERK EC 2.7.11.1; KINASE; Kinase, protein; Membrane protein, integral; Protein kinase, Other; Protein kinase, Ser/Thr (non-receptor); Translation Q9NZJ5 9451 2p11.2 human Y585-p 35518100 NDIKNSGyISRYLTD enzymatic activity, induced signaling pathway regulation 25113558 1 1 0 STAT3 activation, PERK-JAK1-STAT3 pathway -CAPN2 CAPN2 EC 3.4.22.53; Motility/polarity/chemotaxis; Protease P17655 824 1q41 human K390-sm 7780001 MNPQYLIkLEEEDED Calpain_III enzymatic activity, induced cell motility, induced 19422794 1 0 0 -Lmna lamin A/C Cytoskeletal P48678 16905 3 F1|3 38.84 cM mouse S392-p 452606 ERLRLSPsPTSQRSR chromatin organization, altered 31576060 11 105 85 -SQSTM1 SQSTM1 Autophagy; Nuclear receptor co-regulator; Ubiquitin conjugating system Q13501 8878 5q35.3 human K420-ub 12256934 LTRLLQTkNYDIGAA UBA_5 protein degradation; ubiquitination autophagy, induced; autophagy, inhibited SQSTM1(DISRUPTS) 28380357; 31241013; 34987184 4 8 25 inhibits p62 phase condensation and dimerization, sequestration of Keap1 and Nrf2-mediated stress response -Lat LAT Adaptor/scaffold; Membrane protein, integral O54957 16797 7|7 F3 mouse Y136-p 447760 EDDYPNGyLVVLPDS LAT activity, induced; intracellular localization; phosphorylation cell differentiation, altered; apoptosis, altered; apoptosis, induced; cell adhesion, altered; signaling pathway regulation; cell growth, altered Fyn(INDUCES) 12065839; 12065840; 15470052; 17081783; 17579183; 20130215; 30911567 24 1 1 Localization of recruited PLCG2 to the membrane/cytoskeleton; ERK phosphorylation; Fyn may be involved in LAT phosphorylation.; upregulation of TGF-beta/SMAD signaling in Hypertrophic Patchymeningitis, increased Th2 cell proliferation, regulates infiltration of blood cells -DAB2 DAB2 Adaptor/scaffold; Tumor suppressor P98082 1601 5p13.1 human T221-p 449256 DLFGDMStPPDLNSP intracellular localization 21097498 1 6 7 displacement of Dab2 from the membrane -SRF SRF Motility/polarity/chemotaxis; Transcription factor P11831 6722 6p21.1 human S162-p 460665 LRRYTTFsKRKTGIM SRF-TF transcription, inhibited 16537394; 19778940 2 0 0 -FUS hnRNP P2 DNA-binding; Nuclear receptor co-regulator; Oncoprotein; RNA splicing; RNA-binding; SUMO LIGASE P35637 2521 16p11.2 human S163-p 1878186700 GQQNQYNsSSGGGGG molecular association, regulation hnRNP P2(DISRUPTS) 35753345 1 1 0 -STIM1 STIM1 Calcium-binding; Endoplasmic reticulum; Membrane protein, integral Q13586 6786 11p15.4 human S608-p 3195758 PSAPPGGsPHLDSSR molecular association, regulation; intracellular localization; activity, inhibited; protein conformation cell motility, induced EB1(DISRUPTS) 25447552; 25562429; 28935720 7 19 0 GPER activation to inhibit SOCE; accelerates cell migration in wound-healing assays; NFAT translocation to the nucleus, multimerization -Oprk1 KOR-1 GPCR, family 1; Membrane protein, integral; Membrane protein, multi-pass; Receptor, GPCR P33534 18387 1 A1|1 1.89 cM mouse S369-p 449609 NTVQDPAsMRDVGGM activity, induced; receptor internalization, induced; receptor desensitization, altered; intracellular localization; phosphorylation signaling pathway regulation 14597630; 19773548; 21370032; 26635353; 35652052 11 1 0 induces phosphorylation of ERK1/2 and p38MAPK, induces KOR/ p38MAPK signaling -Met Met EC 2.7.10.1; KINASE; Kinase, protein; Membrane protein, integral; Oncoprotein; Protein kinase, TK; Protein kinase, tyrosine (receptor) P16056 17295 6 A2|6 7.83 cM mouse Y1311-p 450189 EYCPDALyEVMLKCW PK_Tyr_Ser-Thr molecular association, regulation cell motility, altered; cytoskeletal reorganization GRB2(INDUCES); PIK3C2A(INDUCES); GAB1(INDUCES); SHC1(INDUCES) 10069803; 7708691 6 1 4 activates cell mobility -BCL2 Bcl-2 Apoptosis; Autophagy; Membrane protein, integral; Oncoprotein P10415 596 18q21.33 human T74-p 448632 ARTSPLQtPAAPGAA protein stabilization; ubiquitination apoptosis, altered; apoptosis, induced; apoptosis, inhibited 10669763; 11077443; 12039864 4 0 0 -MORC2 MORC2 DNA-binding Q9Y6X9 22880 22q12.2 human T717-p 3217917 PSPKVIKtPVVKKTE protein degradation; molecular association, regulation cell cycle regulation; carcinogenesis, inhibited; autophagy, induced; cell growth, inhibited; apoptosis, induced LAMP2(INDUCES); HSC70(INDUCES) 36967563 1 9 1 -RAF1 RAF1 EC 2.7.11.1; KINASE; Kinase, protein; Oncoprotein; Protein kinase, Ser/Thr (non-receptor); Protein kinase, TKL P04049 5894 3p25.2 human S497-p 3082308 ATVKSRWsGSQQVEQ PK_Tyr_Ser-Thr enzymatic activity, induced 10998357; 8288587 2 2 0 -PKM PKM Carbohydrate Metabolism - glycolysis and gluconeogenesis; Carbohydrate Metabolism - pyruvate; EC 2.7.1.40; KINASE; Kinase, other; Mitochondrial; Nucleotide Metabolism - purine P14618 5315 15q23 human Y105-p 450528 FASDPILyRPVAVAL PK molecular association, regulation; intracellular localization; enzymatic activity, inhibited; protein conformation; enzymatic activity, induced cell cycle regulation; carcinogenesis, induced; cell motility, induced; cell growth, induced; apoptosis, inhibited; transcription, induced PKM iso2(DISRUPTS); PKM(DISRUPTS); TRIM35(DISRUPTS) 23814019; 24100037; 25208557; 25263439; 25645022; 33623435; 33800513; 34966685; 35054968; 36400183; 36428781 29 33 414 -EZR Ezrin Cytoskeletal; Motility/polarity/chemotaxis P15311 7430 6q25.3 human T567-p 448104 QGRDKYKtLRQIRQG ERM_C activity, induced; molecular association, regulation; intracellular localization; activity, inhibited; protein conformation; phosphorylation cell cycle regulation; carcinogenesis, induced; cell growth, inhibited; cell motility, induced; cell adhesion, induced; signaling pathway regulation; cell differentiation, altered; exocytosis, induced; cell motility, altered; cytoskeletal reorganization; cell adhesion, altered Ezrin(DISRUPTS); Moesin(DISRUPTS); ACTA1(INDUCES) 10893267; 10970850; 14993232; 15531580; 15843435; 16144865; 16873375; 17553936; 18725408; 19386264; 21818323; 21864676; 21979959; 24379416; 24413175; 25375189; 25799996; 26042733; 26405038; 31409639; 31936668; 33583073; 33836044; 34493594; 34540823; 35325754; 35482006; 36899847 68 9 16 -Pink1 PINK1 EC 2.7.11.1; KINASE; Kinase, protein; Membrane protein, integral; Mitochondrial; Protein kinase, Other; Protein kinase, Ser/Thr (non-receptor) Q99MQ3 68943 4|4 D3 mouse S227-p 25792200 MWNISAGsSSEAILS autophagy, induced; cell growth, induced 35145192 8 2 0 induces mitophagy -USP16 USP16 DEUBIQUITINASE; EC 3.4.19.12; Protease; Ubiquitin conjugating system; Ubiquitin-specific protease Q9Y5T5 10600 21q21.3 human T554-p 3217539 EVLTSSPtRNLNGAY UCH protein degradation 28380042 1 5 0 -STING1 STING Apoptosis; Endoplasmic reticulum; Membrane protein, integral; Membrane protein, multi-pass; Mitochondrial Q86WV6 340061 5q31.2 human S366-p 31064700 QEPELLIsGMEKPLP activity, induced; protein degradation; protein stabilization; molecular association, regulation; intracellular localization; phosphorylation carcinogenesis, inhibited; apoptosis, inhibited; transcription, induced; transcription, inhibited; signaling pathway regulation AP1M1(INDUCES); IRF3(INDUCES); STING(INDUCES); AP1S1(INDUCES) 24119841; 25636800; 31527250; 33906974; 34799452; 36261523; 36972172 35 3 0 -PXN PXN iso2 Adaptor/scaffold; Cell adhesion; Cytoskeletal; Motility/polarity/chemotaxis P49023-2 5829 12q24.23 human S126-p 450227 SFPNKQKsAEPSPTV Paxillin cell cycle regulation; carcinogenesis, altered; transcription, altered 20628053 8 28 4 regulates Erk1/2-induced cell proliferation and transcription -Prkaa1 AMPKA1 Autophagy; EC 2.7.11.1; EC 2.7.11.26; EC 2.7.11.27; EC 2.7.11.31; KINASE; Kinase, protein; Protein kinase, CAMK; Protein kinase, Ser/Thr (non-receptor) Q5EG47 105787 15|15 A1 mouse S496-p 450431 ATPQRSGsISNYRSC AdenylateSensor protein degradation; molecular association, regulation; ubiquitination; enzymatic activity, inhibited; phosphorylation TRIM72(INDUCES) 24928508; 33400924 19 46 55 -CAMKK2 CAMKK2 Autophagy; EC 2.7.11.17; KINASE; Kinase, protein; Protein kinase, Other; Protein kinase, Ser/Thr (non-receptor) Q96RR4 10645 12q24.31 human S511-p 2861414 RREERSLsAPGNLLT molecular association, regulation; enzymatic activity, inhibited; phosphorylation 14-3-3 beta(INDUCES) 15209507; 32913128 3 32 15 increases autophosphorylation; inhibits dephosphorylation at S495 -SH2B1 SH2-B-beta Adaptor/scaffold Q9NRF2 25970 16p11.2 human Y753-p 408589400 PRAINNQySFV____ cell growth, inhibited; signaling pathway regulation 29229648 1 0 0 Expression of NGF-responsive genes reduced, inhibit NGF signaling pathway -GSK3B GSK3B EC 2.7.11.1; EC 2.7.11.26; KINASE; Kinase, protein; Protein kinase, CMGC; Protein kinase, Ser/Thr (non-receptor) P49841 2932 3q13.33 human S147-p 51621301 YRVARHYsRAKQTLP Pkinase enzymatic activity, induced 26711256 1 0 0 -CDK9 CDK9 Cell cycle regulation; EC 2.7.11.22; EC 2.7.11.23; KINASE; Kinase, protein; Nuclear receptor co-regulator; Protein kinase, CMGC; Protein kinase, Ser/Thr (non-receptor) P50750 1025 9q34.11 human T186-p 450950 NSQPNRYtNRVVTLW Pkinase protein stabilization; molecular association, regulation; intracellular localization; enzymatic activity, induced carcinogenesis, induced; DNA repair, induced; cell growth, induced; transcription, induced; transcription, inhibited; transcription, altered HEXIM1(INDUCES); HSP90A(DISRUPTS); BRD4(DISRUPTS); TEAD1(INDUCES); CCNT1(INDUCES); EDG-1(INDUCES) RNA(INDUCES) 14627702; 15965233; 18483222; 21098020; 21448926; 21533037; 23658523; 29743242; 36253486 16 28 10 -TET2 TET2 EC 1.14.11.n2; Oxidoreductase; Tumor suppressor Q6N021 54790 4q24 human K1299-ub 38492200 SMYYNGCkFARSKIP Tet_JBP molecular association, regulation; intracellular localization; enzymatic activity, induced DNA(INDUCES) 25557551 1 0 0 -CDKN1A p21Cip1 Cell cycle regulation; Inhibitor P38936 1026 6p21.2 human S146-p 447836 GRKRRQTsMTDFYHS protein degradation; protein stabilization; molecular association, regulation; intracellular localization apoptosis, induced; cell growth, altered 10753973; 11756412; 17855660; 23886938 10 1 0 -Arrb2 ARRB2 Adaptor/scaffold P29067 25388 10q24 rat T277-p 50247604 FCKVYTItPLLSDNR Arrestin_C activity, induced; molecular association, regulation; protein conformation ADRB2(INDUCES); GRK2(INDUCES) 31948726 2 1 0 induces pre-active state -P2rx7 P2X7 Channel, ligand-gated; Membrane protein, integral; Membrane protein, multi-pass; Receptor, misc. Q64663 29665 12q16 rat Y550-p 2179300 SKLRHCAyRSYATWR P2RX7_C cytoskeletal reorganization 11707406 1 0 0 -APPL1 APPL Adaptor/scaffold; Nuclear receptor co-regulator Q9UKG1 26060 3p14.3 human S401-p 449251 ALEAVTPsPSFQQRH signaling pathway regulation 21562756 2 42 0 adiponectin signalling pathway -Smad2 SMAD2 DNA-binding; Transcription factor Q62432 17126 18 E3|18 51.42 cM mouse S467-p 447495 SVRCSSMs_______ molecular association, regulation; intracellular localization carcinogenesis, induced; cell growth, induced; cell motility, induced; cell growth, inhibited; cell differentiation, induced; transcription, induced; signaling pathway regulation SMAD4(INDUCES) 32122971; 34655614; 34799661; 35538070; 37350664 57 1 5 -GAPDH GAPDH Carbohydrate Metabolism - glycolysis and gluconeogenesis; EC 1.2.1.12; Oxidoreductase P04406 2597 12p13.31 human S151-p 3178959 LKIISNAsCTTNCLA activity, induced; molecular association, regulation cell motility, induced; cell growth, induced TRAF2(INDUCES) 37450367 1 17 1 K139 ubiquitylation promotes cell proliferation and motility-migration and metastasis; K139 is critical for its binding to TRAF2 and activation of the NF-kB pathways leading to proliferation and migration -MTMR2 MTMR2 Carbohydrate Metabolism - fructose and mannose; Cofactor and Vitamin Metabolism - riboflavin; Cofactor and Vitamin Metabolism - thiamine; EC 3.1.3.64; EC 3.1.3.95; Motility/polarity/chemotaxis; PHOSPHATASE; Phosphatase, lipid; Protein phosphatase, tyrosine (non-receptor) Q13614 8898 11q21 human S58-p 3195800 STSADNFsPDLRVLR molecular association, regulation; intracellular localization signaling pathway regulation RAB5A(DISRUPTS); APPL(DISRUPTS) 21372139; 23378027 2 29 0 inhibits binding and targting to early endosomes, regulates endosomal shuttling; enhances EGF signaling; localization of S58A mutant to early endosomal structures results in dephosphorylation of PI(3) -EYA3 EYA3 EC 3.1.3.48; PHOSPHATASE; Protein phosphatase, tyrosine (non-receptor) Q99504 2140 1p35.3 human Y77-p 1869778703 QMYSAKPyAHILSVP cell growth, altered 31847183 1 1 0 -Pdpk1 PDK1 EC 2.7.11.1; KINASE; Kinase, protein; Nuclear receptor co-regulator; Protein kinase, AGC; Protein kinase, Ser/Thr (non-receptor) Q9Z2A0 18607 17|17 A3.3 mouse S532-p 5938009 TYYLMDPsGNAHKWC PH_3 enzymatic activity, inhibited 19047061 1 0 0 -BNIP3L BNIP3L Apoptosis; Endoplasmic reticulum; Membrane protein, integral; Mitochondrial; Nuclear envelope O60238 665 8p21.2 human S35-p 65958201 PPAGLNSsWVELPMN BNIP3 molecular association, regulation autophagy, induced LC3B(INDUCES) 28442745 2 0 0 -Cebpa C/EBP-alpha DNA-binding; Transcription factor P05554 24252 1q21 rat T226-p 449825 GHPTPPPtPVPSPHP activity, inhibited transcription, altered 16600022 8 0 0 In 3T3L1 preadipocytes, mutation of T222/T226 to alanines increased transcription at CBE-containing promoter (as compared to WT C/EBP-alpha). S230A had a similar effect as the double T->A mutation. The triple alanine mutation had the highest transcription of the reporter gene. S230A did not reduce T222/226 phosphorylation (although CHIR99021 inhibitor did). -CDC25A CDC25A EC 3.1.3.48; Motility/polarity/chemotaxis; PHOSPHATASE; Protein phosphatase, dual-specificity P30304 993 3p21.31 human S76-p 449340 SNLQRMGsSESTDSG protein degradation; molecular association, regulation; ubiquitination; phosphorylation cell cycle regulation BTRC(INDUCES) 12110582; 12759351; 14681206; 14752276; 15798217; 18167338; 19734889; 20348946; 22179839 12 1 1 -ARHGAP35 GRF-1 GAP; GAP, Rac/Rho; Motility/polarity/chemotaxis; Transcription factor; Tumor suppressor Q9NRY4 2909 19q13.32 human S1236-p 7159801 PKPKPRPsITKATWE RhoGAP_pG1_pG2 activity, inhibited 19103606 2 5 0 -MSH3 MSH3 DNA repair, damage P20585 4437 5q14.1 human K122-ac 9930497 MSGNSEPkKCLRTRN intracellular localization 32900932 1 0 1 -CHKB CHKB EC 2.7.1.32; EC 2.7.1.82; Kinase, other; Lipid Metabolism - glycerophospholipid Q9Y259 1120 22q13.33 human S39-p 5208526 TPKRRRAsSLSRDAE enzymatic activity, induced 27149373 1 9 2 -Msx1 MSX1 DNA-binding; Motility/polarity/chemotaxis P13297 17701 5 B3|5 20.21 cM mouse S136-p 50783957 DALVKAEsPEKLDRT cell cycle regulation; cell growth, induced; transcription, induced; signaling pathway regulation 33080014 1 3 0 Fgf/MAPK signaling for cell growth -Bub1b BUB1B EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, Other; Protein kinase, Ser/Thr (non-receptor); Tumor suppressor Q9Z1S0 12236 2|2 E5 mouse S659-p 3207630 ALIIKKLsPIIEESR intracellular localization; phosphorylation 26028219 9 35 0 Kinetochore-Microtubule attachment destabilization, PP2A-B56 recruitment to KTs; decrease CASC5 phosphorylation -SRSF1 SF2 RNA splicing; RNA-binding; Spliceosome Q07955 6426 17q22 human S133-p 15178110 SGLPPSGsWQDLKDH RRM_1 molecular association, regulation carcinogenesis, inhibited; RNA splicing, inhibited RNA(DISRUPTS) 32453427; 36417875 2 2 2 -CALR Calreticulin ACETYLTRANSFERASE; Acetyltransferase; Calcium-binding; Motility/polarity/chemotaxis; Nuclear receptor co-regulator; Secreted; Secreted, signal peptide P27797 811 19p13.13 human K238-ac 4219809 SKPEDWDkPEHIPDP Calreticulin protein conformation 18795239 1 3 0 -BLNK BLNK Adaptor/scaffold Q8WV28 29760 10q24.1 human Y96-p 447719 EENADDSyEPPPVEQ molecular association, regulation transcription, altered PLCG1(INDUCES); PLCG2(INDUCES); Btk(INDUCES); NCK2(INDUCES); VAV1(INDUCES) 12456653; 9697839 6 1 0 -Camk2b CAMK2B EC 2.7.11.17; KINASE; Kinase, protein; Protein kinase, CAMK; Protein kinase, Ser/Thr (non-receptor) P08413 24245 14q21 rat T287-p 450048 SMMHRQEtVECLKKF activity, induced; molecular association, regulation; intracellular localization; enzymatic activity, induced; phosphorylation cell growth, inhibited; signaling pathway regulation RPT6(INDUCES); CAMK2A(INDUCES); ACTN4(DISRUPTS); CAMK2B(INDUCES); MARCKS(INDUCES); SYN1(INDUCES) 17144902; 20178748; 21725312; 23490331; 25944910; 9681448 32 17 109 diabetes-type1 and type2-related signaling in brain; phosphorylation decreased dendritic length -CSF3R GCSFR Membrane protein, integral; Receptor, cytokine Q99062 1441 1p34.3 human K705-ub 9381804 VLEEDEKkPVPWESH receptor internalization, induced; protein degradation; intracellular localization; phosphorylation cell growth, inhibited; signaling pathway regulation 19453968 2 0 0 regulates production of neutrophilic granulocytes, regulates STAT5 activation -Crebbp CBP ACETYLTRANSFERASE; Acetyltransferase; DNA-binding; EC 2.3.1.48; Motility/polarity/chemotaxis; Nuclear receptor co-regulator; Transcription, coactivator/corepressor Q6JHU9 54244 10q12 rat S301-p 448068 PQLASKQsMVNSLPA transcription, induced 11970865 1 0 0 -Cebpb C/EBP-beta DNA-binding; Motility/polarity/chemotaxis; Transcription factor P28033 12608 2 H3|2 87.58 cM mouse S64-p 456166 HERAIDFsPYLEPLA protein conformation cell growth, inhibited; transcription, altered; transcription, inhibited 15878863; 21804532 8 0 1 the 3'UTRC/EBP-beta alters target gene speci?city -Alyref2 Refbp2 DNA-binding; RNA-binding Q9JJW6 56009 1|1 H3 mouse R40-m2 13906420 PAIARGGrNRPAPYS molecular association, regulation RNA(DISRUPTS) 20129943 1 1 0 -PHF8 PHF8 DEMETHYLASE; Demethylase; EC 1.14.11.27; Nucleolus Q9UPP1 23133 Xp11.22 human S854-p 3216123 DAEYIYPsLESDDDD molecular association, regulation TOPBP1(INDUCES) 33010150 1 25 15 -ACTA1 ACTA1 Cell development/differentiation; Contractile; Cytoskeletal; Motility/polarity/chemotaxis P68135 rabbit K317-ac 474928 GIADRMQkEITALAP Actin activity, inhibited 30962575 1 4 7 CAP/actin inhibitory potency -Jun Jun Oncoprotein; Transcription factor P05627 16476 4 C5|4 43.34 cM mouse K229-sm 2793916 HPRLQALkEEPQTVP Jun molecular association, regulation transcription, inhibited DNA(DISRUPTS) 10788439; 23396363 5 2 0 -GJD2 GJD2 Cell adhesion; Channel, misc.; Membrane protein, integral; Membrane protein, multi-pass Q9UKL4 57369 15q14 human S315-p 471389 PNFGRTQsSDSAYV_ molecular association, regulation PSD-95(DISRUPTS) 33110101 2 1 0 -Kdr VEGFR2 EC 2.7.10.1; KINASE; Kinase, protein; Membrane protein, integral; Protein kinase, TK; Protein kinase, tyrosine (receptor) P35918 16542 5 C3.3|5 40.23 cM mouse Y1173-p 447901 AQQDGKDyIVLPMSE activity, induced; receptor internalization, induced; molecular association, regulation; protein stabilization; intracellular localization; phosphorylation signaling pathway regulation 20434959; 21402774; 21543326; 25119572 40 0 0 -Atm ATM DNA repair, damage; EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, Ser/Thr (non-receptor); Protein kinase, atypical; Tumor suppressor Q62388 11920 9 A5.3|9 29.12 cM mouse S1899-p 467199 PANSDSEsENFLRCC chromatin organization, altered 19047460 3 3 0 -SLC39A7 SLC39A7 Membrane protein, integral; Membrane protein, multi-pass; Transporter; Transporter, SLC family Q92504 7922 6p21.32 human T294-p 26420164 QKRRGGStVPKDGPV Zip activity, induced; phosphorylation exocytosis, induced; signaling pathway regulation 28205653 1 1 1 maximal activation, SLC39A7 and Akt activation, zinc release and downstream effectors GSK3B, and p70 S6, phosphorylation of multiple kinases -NABP2 OBFC2B Cell cycle regulation; DNA repair, damage Q9BQ15 79035 12q13.3 human T117-p 12526701 EPNPEYStQQAPNKA protein stabilization FBXO15(DISRUPTS) DNA(INDUCES) 23178594; 25249620 4 1 0 -LAT LAT iso2 Adaptor/scaffold; Membrane protein, integral O43561-2 27040 16p11.2 human T155-p 451994 PSAPALStPGIRDSA LAT activity, inhibited 15192708 1 0 11 -MARK2 MARK2 EC 2.7.11.1; EC 2.7.11.26; KINASE; Kinase, protein; Protein kinase, CAMK; Protein kinase, Ser/Thr (non-receptor) Q7KZI7 2011 11q13.1 human S569-p 2192738 PQRVPVAsPSAHNIS cell cycle regulation; carcinogenesis, induced; apoptosis, inhibited 35780183 1 30 0 -BTG2 BTG2 Transcription factor P78543 7832 1q32.1 human K5-ub 1877015604 ___MSHGkGTDMLPE protein degradation cell cycle regulation; cell growth, induced 31992359 1 1 0 -Crmp1 CRMP-1 Cell development/differentiation; Cytoskeletal; Hydrolase Q62950 25415 14q21 rat Y504-p 454682 GMYDGPVyEVPATPK molecular association, regulation cell growth, induced; signaling pathway regulation FLNA(INDUCES) 33449368 3 13 208 induces Sema3A signaling -RB1 Rb Nuclear receptor co-regulator; Oncoprotein; Transcription, coactivator/corepressor; Tumor suppressor P06400 5925 13q14.2 human R775-m2 36533404 ILQYASTrPPTLSPI Rb_C phosphorylation cell cycle regulation; transcription, inhibited 25348716 1 0 0 -KCNB1 Kv2.1 Channel, cation; Channel, ligand-gated; Channel, potassium; Membrane protein, integral; Membrane protein, multi-pass Q14721 3745 20q13.13 human K149-sm 1877715601 EQMNEELkREAETLR exocytosis, inhibited 31085831 1 0 0 controlled the occurrence of membrane fusion -LGALS3 galectin-3 Cell surface; Extracellular matrix; Motility/polarity/chemotaxis P17931 3958 14q22.3 human S12-p 451567 FSLHDALsGSGNPNP protein conformation 24269589; 26911284 4 1 0 may allosterically influence carbohydrate binding to the S-face; little effect on interactions between the NT and CRD F-face; Phosphorylation of S6 and S12 In N-terminal promotes association with carbohydrate recognition domain (CRD), while phosphorylation of Y107 and Y118 attenuates this interaction. -CSNK2B CK2B KINASE; Protein kinase, regulatory subunit P67870 1460 6p21.33 human S3-p 447647 _____MSsSEEVSWI protein stabilization 12032843 2 11 0 -Bcl2l11 BIM Apoptosis O88498 64547 3q36 rat K3-ub 25087001 _____MAkQPSDVNS protein degradation 21378313 3 0 0 BIM was still degraded in the absence of these lysines defining a novel ubiquitin-independent pathway. -Grk2 GRK2 EC 2.7.11.15; KINASE; Kinase, protein; Protein kinase, AGC; Protein kinase, Ser/Thr (non-receptor) Q99MK8 110355 19 A|19 3.98 cM mouse Y13-p 456872 AVLADVSyLMAMEKS cell motility, altered 18369319 5 0 0 -TLR3 TLR3 Membrane protein, integral; Receptor, cytokine O15455 7098 4q35.1 human Y759-p 450187 EQFEYAAyIIHAYKD TIR molecular association, regulation; phosphorylation signaling pathway regulation; transcription, altered TICAM1(INDUCES) 12509442; 17178723; 22810896 4 0 0 antiviral TLR3 signaling; increases phosphorylation of some NFKB sites -YAP1 YAP1 Oncoprotein; Transcription, coactivator/corepressor P46937 10413 11q22.1 human S227-p 1874514400 VQQNMMNsASGPLPD protein stabilization; molecular association, regulation; ubiquitination carcinogenesis, induced; cell growth, induced; transcription, induced DNA(INDUCES) 34345207 1 0 0 -RORA RORA DNA-binding; Nuclear receptor P35398 6095 15q22.2 human R37-m2 1883509400 PLNQESArKSEPPAP protein degradation 36114756 1 0 0 PRMT5 is involved in RORa degradation by regulating ITCH binding R37A (mutant) -PAK2 PAK2 EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, STE; Protein kinase, Ser/Thr (non-receptor) Q13177 5062 3q29 human Y139-p 3571405 SNTVKQKyLSFTPPE enzymatic activity, induced 12215529 2 5 46 -BCAR1 P130Cas Adaptor/scaffold; Motility/polarity/chemotaxis P56945 9564 16q23.1 human Y287-p 451538 RDPLLEVyDVPPSVE cell growth, induced 26867768 2 17 284 metastases -CHRM2 mAChR M2 GPCR, family 1; Membrane protein, integral; Membrane protein, multi-pass; Receptor, GPCR P08172 1129 7q33 human T287-p 459103 KESSNDStSVSAVAS 7tm_1 receptor internalization, altered 9162044 3 0 0 Mutation of S286 T287 S288 S290 to A caused a faster rate and a greater extent of receptor internalization after agonist stimulation (transients only, not observed in stables). Mutation of all 8 sites prevented internalization (in both transients and stables). -NPM1 NPM1 Nucleolus; Oncoprotein; RNA-binding; Translation P06748 4869 5q35.1 human K229-ac 461146 SKGQESFkKQEKTPK molecular association, regulation; intracellular localization transcription, altered H3(INDUCES) 19581289 1 3 116 K212/215/229/230/257/267/292R mutant -Tsc2 TSC2 iso2 Cell cycle regulation; GAP; GAP, misc.; Nuclear receptor co-regulator; Tumor suppressor P49816-2 24855 10q12 rat S1346-p 450212 QPLSKSSsSPELQTL phosphorylation apoptosis, altered; cell growth, altered 14651849; 17244624 19 14 6 -Stat3 STAT3 DNA-binding; Motility/polarity/chemotaxis; Nuclear receptor co-regulator; Transcription factor P42227 20848 11 D|11 63.82 cM mouse T717-gl 90001800 FICVTPTtCSNTIDL transcription, inhibited 28280036 1 1 0 -Mybl2 B-Myb DNA-binding; Motility/polarity/chemotaxis; Transcription factor P48972 17865 2 H2|2 84.0 cM mouse T447-p 452026 NSLTPKStPVKTLPF activity, induced 9840932 3 0 0 -Lipe HSL EC 3.1.1.79; Lipase P15304 25330 1q21 rat S960-p 450195 GFHPRRSsQGVLHMP Abhydrolase_3 transcription, induced 28716938 29 14 16 regulation of steroidogenesis -Lpp LPP Adaptor/scaffold; Cytoskeletal; Motility/polarity/chemotaxis Q8BFW7 210126 16|16 B1 mouse Y297-p 463380 YTSNQGRyYEPYYAA cell cycle regulation; cell motility, altered 18515860 1 4 21 -Pygl PYGL Carbohydrate Metabolism - starch and sucrose; EC 2.4.1.1; Transferase Q9ET01 110095 12 C2|12 29.01 cM mouse K470-ac 14321567 IVKTQVFkDFSELEP Phosphorylase enzymatic activity, inhibited; phosphorylation PPP1CA(INDUCES) 22225877 1 3 0 acetylation enhances its interaction with the PPP1CA substrate-targeting PL, promoting PYGL dephosphorylation -USF1 USF1 DNA-binding; Transcription factor P22415 7391 1q23.3 human S186-p 15428820 APRTHPYsPKSEAPR activity, induced 21873430 1 12 8 -RLIM RNF12 EC 6.3.2.-; Ligase; Transcription, coactivator/corepressor; UBIQUITIN LIGASE; Ubiquitin conjugating system; Ubiquitin ligase Q9NVW2 51132 Xq13.2 human S215-p 18014966 QRRARSRsPDHRRTR intracellular localization cell motility, induced; apoptosis, inhibited 23904271 1 0 0 phosphorylated S214 (human) or S215 (murine) RNF12 is localized in nucleus; shuttling of RNF12 is important for promoting cell motility and alveolar cell survival -DVL2 DVL2 Adaptor/scaffold; Motility/polarity/chemotaxis O14641 1856 17p13.1 human T206-p 17301000 MTSELEStSLGDSDE Dishevelled cell cycle regulation 20823832 1 0 0 -CTNND1 CTNND1 Actin-binding; Adaptor/scaffold; Cell adhesion; G protein regulator, misc.; Motility/polarity/chemotaxis O60716 1500 11q12.1 human T906-p 469141 SLDNNYStPNERGDH molecular association, regulation; ubiquitination carcinogenesis, induced; cytoskeletal reorganization SMURF1(INDUCES) 32010791 1 17 76 facilitates adherens junction dissociation -PML PML Nucleolus; Oncoprotein; SUMO LIGASE; SUMO conjugating system; SUMO ligase; Transcription factor; Tumor suppressor; Ubiquitin conjugating system P29590 5371 15q24.1 human S36-p 451469 PSEGRQPsPSPSPTE sumoylation apoptosis, altered 19015637 2 15 0 induces sumoylation -RPS6KA5 MSK1 EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, AGC; Protein kinase, Ser/Thr (non-receptor) O75582 9252 14q32.11 human S376-p 448216 EKLFQGYsFVAPSIL Pkinase_C enzymatic activity, induced 15568999 23 19 41 -NPAT NPAT Cell cycle regulation; Transcription regulation Q14207 4863 11q22.3 human S1100-p 2286403 VSFPNLDsPNVSSTL NPAT_C transcription, induced 10995387 1 1 0 multiple sites deletion mutant -CENPA CENPA DNA-binding P49450 1058 2p23.3 human S19-p 478530 APRRRSPsPTPTPGP Histone molecular association, regulation; intracellular localization; protein conformation cell cycle regulation; cell growth, induced HJURP(DISRUPTS) 23818633; 28760857 2 39 8 chromosome segregation; localization to centromeres, tumor progression -AFF1 AF-4 Oncoprotein; Transcription factor P51825 4299 4q21.3-q22.1 human K972-ac 1878271700 DLHMREAkKMKQKAE molecular association, regulation; intracellular localization transcription, inhibited MLLT3(DISRUPTS); CDK9(DISRUPTS); ELL(DISRUPTS) 31611376 1 0 0 Acetylation inhibits SEC component recruitment and is required for transcription inhibition and cell survival after exposure to genotoxic reagents. -Nup62 NUP62 Adaptor/scaffold; Nucleoporin P17955 65274 1q22 rat Y425-p 463925 KEQSGTIyLQHADEE Nsp1_C intracellular localization 25349423 1 0 5 -Ppp2r5b PPP2R5B Motility/polarity/chemotaxis; Protein phosphatase, regulatory subunit Q6PD28 225849 19|19 A mouse S46-p 18261152 ARPRRSHsSSQFRYQ molecular association, regulation; phosphorylation PPP2CA(INDUCES); PPP2R5B(INDUCES) 21329884 1 4 1 PPP2R2R5B phosphorylation by CLK2 is required for the PPP2CA-AKT complex; induces AKT dephosphorylation -CEACAM1 CEACAM1 Cell adhesion; Immunoglobulin superfamily; Membrane protein, integral; Motility/polarity/chemotaxis P13688 634 19q13.2 human T457-p 3439801 CFLHFGKtGRASDQR molecular association, regulation; activity, inhibited apoptosis, altered Calmodulin(DISRUPTS) 19146852; 30639287 5 1 0 calcium-calmodulin binding ; blocks formation of lumen -MEN1 MEN1 iso1 Transcription, coactivator/corepressor O00255-1 4221 11q13.1 human S399-p 477697 EERPGEQsQGTQSQG Menin phosphorylation 21264250 1 2 6 important for dephosphorylation of S487 -KCNQ1 Kv7.1 Channel, potassium; Membrane protein, integral; Membrane protein, multi-pass P51787 3784 11p15.5-p15.4 human T513-p 456164 LREHHRAtIKVIRRM KCNQ_channel activity, induced 12879210 1 0 0 -TBXA2R TXA2-R iso2 GPCR, family 1; Membrane protein, integral; Membrane protein, multi-pass; Receptor, GPCR P21731-2 6915 19p13.3 human S330-p 18790001 LSTRPRRsLTLWPSL receptor desensitization, altered 12147288; 14530262 2 0 0 -SIRT1 SIRT1 Apoptosis; DEACETYLASE; Deacetylase; EC 3.5.1.-; Nuclear receptor co-regulator Q96EB6 23411 10q21.3 human S615-p 7998455 GEKNERTsVAGTVRK molecular association, regulation; acetylation; protein conformation; enzymatic activity, induced transcription, induced p53(INDUCES); DBC1(DISRUPTS) 34216621 1 4 9 inhibits PGC-1a deacetylation -Prkn PARK2 EC 6.3.2.-; EC 6.3.2.19; Ligase; Translation; Translation regulation; UBIQUITIN LIGASE; Ubiquitin conjugating system; Ubiquitin ligase Q9JK66 56816 1q11 rat S65-p 25538008 NCDLEQQsIVHIVQR ubiquitin ubiquitination; enzymatic activity, induced ubiquitin(INDUCES) 26254304 34 10 0 RING0/RING1 interface are remodelled, PARK2 is activated by phosphorylation of its N-terminal ubiquitin-like (Ubl) domain and binding of phosphoubiquitin. -Fosl2 FRA2 DNA-binding; Transcription factor P47930 14284 5 B1|5 17.33 cM mouse T322-p 14573760 SDSLNSPtLLAL___ protein stabilization cell differentiation, inhibited 23807221 2 5 0 -PELI1 PELI1 Adaptor/scaffold; EC 6.3.2.-; EC 6.3.2.19; Ligase; UBIQUITIN LIGASE; Ubiquitin conjugating system; Ubiquitin ligase Q96FA3 57162 2p14 human T288-p 7388016 QCPVGFNtLAFPSMK Pellino ubiquitination; enzymatic activity, induced 19264966 2 0 0 -Glp1r GLP1R GPCR, family 2; Membrane protein, integral; Membrane protein, multi-pass; Receptor, GPCR P32301 25051 20p12 rat S451-p 451369 SSGATVGsSVYAATC receptor desensitization, altered 8702711 1 0 0 -RBL2 Rb-like 2 Transcription, coactivator/corepressor; Tumor suppressor Q08999 5934 16q12.2 human S688-p 449729 RLFVENDsPSDGGTP molecular association, regulation cell cycle regulation E2F4(DISRUPTS) 11157749 3 6 0 -DENR DENR RNA-binding; Translation O43583 8562 12q24.31 human S73-p 476007 AKLTVENsPKQEAGI protein stabilization; molecular association, regulation cell cycle regulation; translation, induced MCTS1(INDUCES) 35115540 1 52 0 -KIF4A KIF4A Microtubule-binding; Motor O95239 24137 Xq13.1 human T799-p 479906 PPKLRRRtFSLTEVR molecular association, regulation; intracellular localization; enzymatic activity, induced cell cycle regulation; cytoskeletal reorganization PRC1(INDUCES) 23940115; 25512391; 28992084; 31881080 5 27 161 -TP53BP1 53BP1 DNA repair, damage; Transcription, coactivator/corepressor Q12888 7158 15q15.3 human S1778-p 458312 FNKQYTEsQLRAGAG apoptosis, altered 19876065 5 0 1 -Mlph MLPH Adaptor/scaffold Q91V27 171531 1 D|1 45.73 cM mouse S498-p 7103618 SGKPRRKsGIPIFLP Rab_eff_C molecular association, regulation TUBA1A(DISRUPTS) 28559319 1 5 0 -KCNQ2 Kv7.2 Channel, potassium; Membrane protein, integral; Membrane protein, multi-pass O43526 3785 20q13.33 human S476-p 481668 ADQSLEDsPSKVPKS KCNQ_channel activity, inhibited neural plasticity 36070693 2 5 0 -HOXB7 HOXB7 DNA-binding; Motility/polarity/chemotaxis; Transcription factor P09629 3217 17q21.32 human T204-p 465572 KTAGPGTtGQDRAEA cell differentiation, altered 11290787 1 0 0 -IFNAR2 IFNAR2 Membrane protein, integral; Receptor, cytokine P48551 3455 21q22.11 human Y269-p 26416400 VTLKWIGyICLRNSL molecular association, regulation transcription, induced; signaling pathway regulation STAT2(DISRUPTS) 34813358 2 0 0 induces STAT phosphorylation and signaling -LRRK2 LRRK2 EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, Ser/Thr (non-receptor); Protein kinase, TKL Q5S007 120892 12q12 human S955-p 4725908 RKRKILSsDDSLRSS protein stabilization; ubiquitination; enzymatic activity, inhibited; phosphorylation 25009464; 34144124 15 7 0 induces dephosphorylation at autophosphorylation sites; inhibits ubiquitination -NEIL2 NEIL2 DNA repair, damage; EC 4.2.99.18; Hydrolase; Lyase; Microtubule-binding Q969S2 252969 8p23.1 human K50-ac 458948 QDTQVHGkKLFLRFD enzymatic activity, inhibited DNA repair, inhibited 15175427 1 1 0 -FANCD2 FANCD2 DNA repair, damage Q9BXW9 2177 3p25.3 human S705-p 1883582906 NLLPLLFsQDFAKDG activity, induced; molecular association, regulation; ubiquitination; intracellular localization signaling pathway regulation DNA(INDUCES) 37392383 1 1 0 regulates the FA pathway -RIPK1 RIPK1 EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, Ser/Thr (non-receptor); Protein kinase, TKL Q13546 8737 6p25.2 human K316-ub 21183588 SNENAVVkRMQSLQL protein degradation 35711363 2 4 0 degradation and inhibited necroptosis -Rag1 RAG1 DNA-binding; EC 3.1.-.-; EC 6.3.2.-; EC 6.3.2.19; Ligase; UBIQUITIN LIGASE; Ubiquitin conjugating system; Ubiquitin ligase P15919 19373 2 E2|2 53.88 cM mouse K233-ub 41389904 QPNVQLSkKLKTVLN RAG1_imp_bd ubiquitination; enzymatic activity, induced 26124138; 34402853 2 0 0 helps restrict RAG1 protein levels, but does not result in impaired B cell development and decreased Igh, Igk, Igl and Tcrb recombination (P326G mice). ; autoubiquitylation; induces DNA cleavage by V(D)J recombination -NPHP1 NPHP1 Cell adhesion O15259 4867 2q13 human S126-p 26395105 EESESEDsEDSGGEE molecular association, regulation; intracellular localization PACS-1(INDUCES) 16308564 1 0 0 -SUPT5H SPT5 RNA-binding; Transcription, coactivator/corepressor O00267 6829 19q13.2 human R681-m2 475964 HPSAGGQrGGFGSPG transcription, inhibited 12718890 1 3 0 inhibition of in vitro transcription assays and HIV-1 gene expression -STX5 STX5 iso2 Membrane protein, integral Q13190-2 6811 11q12.3 human K270-ub 15398358 AAHSEILkYFQSVTS SNARE molecular association, regulation cell cycle regulation BET1(DISRUPTS); NSFL1C(INDUCES) 27404360 1 0 1 regulation of Golgi structure assembly, Golgi fragmentation -NKX3-1 NKX3-1 DNA-binding; Transcription factor; Tumor suppressor Q99801 4824 8p21.2 human Y222-p 28750700 NSYPYYPyLYCVGSW molecular association, regulation; phosphorylation ATM(INDUCES) 23890999 1 0 0 induces phosphorylation of p53 -Nfatc2 NFAT1 DNA-binding; Transcription factor Q60591 18019 2 H3|2 88.91 cM mouse S238-p 449626 DSCLGRHsPVPRPAS transcription, inhibited 11030334 0 14 6 -IFI16 IFI16 Transcription factor Q16666 3428 1q23.1 human K128-ac 4129126 EATPGAQkRKKSTKE intracellular localization 22691496 1 1 12 -HNRNPUL1 E1B-AP5 RNA splicing; RNA-binding Q9BUJ2 11100 19q13.2 human R656-m2 15381104 SGGGGNYrGGFNRSG molecular association, regulation; intracellular localization NBS1(INDUCES) 26020839 1 2 13 ecruitment at sites of damage -RPA1 RPA1 DNA-binding P27694 6117 17p13.3 human K449-sm 580826242 WKTLYEVkSENLGQG DNA repair, induced 22661229 1 2 0 -PPARG PPAR-gamma iso2 DNA-binding; Nuclear receptor; Transcription factor P37231-2 5468 3p25.2 human K265-ac 25780501 GEDKIKFkHITPLQE transcription, induced 28416226 4 1 0 -SYK Syk EC 2.7.10.2; KINASE; Kinase, protein; Protein kinase, TK; Protein kinase, tyrosine (non-receptor) P43405 6850 9q22.2 human Y631-p 459327 LRLRNYYyDVVN___ enzymatic activity, altered transcription, altered 9624129 3 2 2 -RGS4 RGS4 GAP; GAP, RGS Q0R4E4 100009014 rabbit S108-p 25752012 IKSPSKLsPKAKKIY RGS molecular association, regulation G-alpha(q)(INDUCES) 24407588 1 0 1 -Bcl2l11 BIM Apoptosis O54918 12125 2|2 F1 mouse S73-p 3306339 PGPFATRsPLFIFVR protein degradation apoptosis, inhibited 18498746 3 15 6 -HNRNPK hnRNP K RNA splicing; RNA-binding; Spliceosome P61978 3190 9q21.32 human Y230-p 456001 QPYDPNFyDETYDYG translation, altered 12052863 1 1 2 based on Y72/225/230/234/236/380A mutant -App APP Apoptosis; Cell surface; Membrane protein, integral; Receptor, misc.; Transcription factor P12023 11820 16 C3.3|16 46.92 cM mouse Y757-p 448202 SKMQQNGyENPTYKF APP_amyloid molecular association, regulation SHC1(INDUCES) 11877420 14 20 864 -E2F1 E2F1 DNA-binding; Transcription factor Q01094 1869 20q11.22 human K185-m1 14985900 QLIAKKSkNHIQWLG E2F_TDP protein degradation; acetylation; ubiquitination; phosphorylation apoptosis, inhibited; transcription, inhibited 20603083; 27132511 3 0 0 stabilization of the E2F1-K185L mutant; inhibits phosphorylation of E2F1 at S364 and acetylation at a distant residue -ITGB4 ITGB4 Cell adhesion; Membrane protein, integral; Motility/polarity/chemotaxis; Receptor, misc. P16144 3691 17q25.1 human S1356-p 451653 YSDDVLRsPSGSQRP molecular association, regulation cell motility, altered; cytoskeletal reorganization Plectin-1(DISRUPTS) 17615294; 20870721 6 3 2 -SFN 14-3-3 sigma Adaptor/scaffold P31947 2810 1p36.11 human S69-p 454996 LSSIEQKsNEEGSEE 14-3-3 molecular association, regulation carcinogenesis, induced; cell growth, induced; transcription, induced; signaling pathway regulation SMAD3(INDUCES); p53(DISRUPTS) DNA(INDUCES) 23741479 2 1 0 Regulates stemness and radioresistance in breast cancer cells; TGFb/Smad3 and p53/21 signaling pathways -AURKB AurB EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, Other; Protein kinase, Ser/Thr (non-receptor) Q96GD4 9212 17p13.1 human T73-p 23085287 DILTRHFtIDDFEIG protein stabilization cell cycle regulation; carcinogenesis, induced; cell growth, induced 34301793 1 1 1 -NCOA3 SRC-3 ACETYLTRANSFERASE; Acetyltransferase; EC 2.3.1.48; Motility/polarity/chemotaxis; Nuclear receptor co-regulator; Transcription, coactivator/corepressor Q9Y6Q9 8202 20q13.12 human S1042-p 4252806 DDLVGPPsNLEGQSD protein stabilization; molecular association, regulation PSMA3(DISRUPTS) 18313384 1 0 0 some subset of these 8 residues -PGR PR DNA-binding; Nuclear receptor; Transcription factor P06401 5241 11q22.1 human K464-m1 31839903 TLECILYkAEGAPPQ Prog_receptor molecular association, regulation cell adhesion, induced; transcription, induced SMRT(INDUCES); N-CoR1(INDUCES) 24415758 1 1 0 regulates ligand-sensitivity and PR activity -IL10RA IL10RA Membrane protein, integral; Receptor, cytokine Q13651 3587 11q23.3 human Y496-p 449608 PPALAKGyLKQDPLE molecular association, regulation Src(DISRUPTS); CSRP1(INDUCES); STAT3(DISRUPTS) 12802285; 26956044 2 0 1 -Pik3r1 PIK3R1 KINASE; Kinase, lipid; Motility/polarity/chemotaxis P26450 18708 13 D1|13 53.92 cM mouse S652-p 20831301 TFLVRESsKQGCYAC SH2 molecular association, regulation signaling pathway regulation 21825134 1 1 0 impairs PI3K pathway activation; inhibits binding to to phospho-Tyr peptides -TP63 p63 iso2 DNA-binding; Transcription factor Q9H3D4-2 8626 3q28 human T357-p 34371382 QHLLQKQtSIQSPSS molecular association, regulation DNA(INDUCES) 34761935 0 1 1 -SPDEF SPDEF DNA-binding; Motility/polarity/chemotaxis; Nuclear receptor co-regulator; Transcription factor O95238 25803 6p21.31 human S238-p 54165904 SEESWTDsEVDSSCS protein degradation cell motility, induced 26885618 1 0 0 enhances migration and invasion of prostate cancer cells -Acaca ACC1 Carbohydrate Metabolism - propanoate; Carbohydrate Metabolism - pyruvate; EC 6.3.4.14; EC 6.4.1.2; Ligase; Lipid Metabolism - fatty acid biosynthesis Q5SWU9 107476 11|11 C mouse S79-p 448292 FHMRSSMsGLHLVKQ enzymatic activity, inhibited carcinogenesis, induced; autophagy, induced; apoptosis, inhibited; autophagy, inhibited 25050742; 33779513; 34425110; 34588305; 35483524 166 76 11 -JAK2 JAK2 EC 2.7.10.2; KINASE; Kinase, protein; Oncoprotein; Protein kinase, TK; Protein kinase, tyrosine (non-receptor) O60674 3717 9p24.1 human K912-sm 31899106 LQHDNIVkYKGVCYS PK_Tyr_Ser-Thr molecular association, regulation; intracellular localization GH receptor(DISRUPTS) 23581279 1 0 0 translocation into the nucleus -Mapt Tau ACETYLTRANSFERASE; Acetyltransferase; Cytoskeletal P10637 17762 11 67.79 cM|11 E1 mouse T473-p 447932 KTTPSPKtPPGSGEP neural plasticity 35701839; 36186135 107 36 23 -LIMD1 LIMD1 Motility/polarity/chemotaxis; Tumor suppressor Q9UGP4 8994 3p21.31 human S277-p 451975 RVSPGLPsPNLENGA cell cycle regulation; carcinogenesis, inhibited; cell growth, inhibited; cell motility, inhibited 30600590 1 18 9 mitotic phosphorylation required for mitotic progression -FHOD1 FHOD1 Actin-binding Q9Y613 29109 16q22.1 human S1131-p 451843 AARERKRsRGNRKSL activity, induced cytoskeletal reorganization; cell growth, altered FHOD1(DISRUPTS) 18239683; 21106951 3 1 4 autoinhibitory interaction between C- and N-terminal part of FHOD1 is attenuated in S1130D/S1136D/T1140D triple mutant -PML PML Nucleolus; Oncoprotein; SUMO LIGASE; SUMO conjugating system; SUMO ligase; Transcription factor; Tumor suppressor; Ubiquitin conjugating system P29590 5371 15q24.1 human K515-ac 4659503 QPRPSTSkAVSPPHL DUF3583 sumoylation cell cycle regulation; apoptosis, induced 18621739 1 0 0 -CSF2RB CSF2RB Membrane protein, integral; Receptor, cytokine P32927 1439 22q12.3 human Y711-p 450123 DPGVASGyVSSADLV activity, induced; molecular association, regulation; phosphorylation apoptosis, altered; cell motility, altered; transcription, altered; cell growth, altered GRB2(INDUCES); SHC1(INDUCES); SHP-2(INDUCES) 10329850; 10672044; 9257712 3 0 0 Phosphorylation of Y628, Y711, or Y766 is necessary and sufficient for STAT activation by IL-5. -Ppargc1a PGC-1 alpha Nuclear receptor co-regulator; Transcription, coactivator/corepressor O70343 19017 5|5 C1 mouse S538-p 486320 SLFDVSPsCSSFNSP transcription, altered 17609368 1 1 0 -PML PML iso4 Nucleolus; Oncoprotein; SUMO LIGASE; SUMO conjugating system; SUMO ligase; Transcription factor; Tumor suppressor; Ubiquitin conjugating system P29590-4 5371 15q24.1 human T28-p 451468 PTMPPPEtPSEGRQP protein stabilization apoptosis, altered 15093545 1 1 0 Phosphorylation of PML is associated with enhanced sumoylation and apoptosis induced by As2O3. -SNAI2 Snail2 Apoptosis; C2H2-type zinc finger protein; Motility/polarity/chemotaxis; Transcription factor O43623 6591 8q11.21 human K116-ac 59171802 EEERLQSkLSDPHAI protein degradation; ubiquitination carcinogenesis, inhibited; transcription, induced 27783945 1 1 0 -Pou5f1 Oct4 DNA-binding; Transcription factor P20263 18999 17 B1|17 18.69 cM mouse S12-p 18496900 LASDFAFsPPPGGGD protein degradation cell cycle regulation 31306665 2 0 0 dispensable for self-renewal and pluripotency of mouse ES cells; -ULK1 ULK1 Autophagy; EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, Other; Protein kinase, Ser/Thr (non-receptor) O75385 8408 12q24.33 human S423-p 1880900310 GRAGPFSsSRCGASV protein degradation autophagy, inhibited 35931119 1 0 0 -Raf1 RAF1 EC 2.7.11.1; KINASE; Kinase, protein; Oncoprotein; Protein kinase, Ser/Thr (non-receptor); Protein kinase, TKL Q99N57 110157 6 E3|6 53.62 cM mouse S233-p 448651 ASSQHRYsTPHAFTF enzymatic activity, inhibited cell growth, altered 11997508 3 1 2 -PGRMC1 PGRMC1 Membrane protein, integral; Receptor, misc. O00264 10857 Xq24 human S181-p 452525 GEEPTVYsDEEEPKD molecular association, regulation; phosphorylation cell cycle regulation; carcinogenesis, induced; apoptosis, altered; cell growth, induced; apoptosis, induced; apoptosis, inhibited; transcription, induced PHB(INDUCES) 18922159; 19340614; 29069804; 34830790; 35137666 6 115 149 induces AKT/ERK phosphorylation; binding to PHB inhibits PHB binding to ER-alpha -GATA4 GATA4 Motility/polarity/chemotaxis; Transcription factor G1FC91 water buffalo S35-p 450013 IKPQRRLsASRRVGL molecular association, regulation transcription, induced DNA(INDUCES) 22245270 9 1 1 binds CYP19 gene promoter and induces its transcription -Myl9 MRLC1 Contractile; Motility/polarity/chemotaxis Q64122 296313 3q42 rat S20-p 1863500 KRPQSATsNVFAMFD cytoskeletal reorganization 21887379 49 65 294 T19, S20 di-phosphorylation is recquired for dendritic spine maturation; mono phosphorylation inhibits spine maturation. -CERT1 COL4A3BP EC 2.7.11.9; KINASE; Kinase, protein; Lipid-binding; Protein kinase, Ser/Thr (non-receptor); Protein kinase, atypical Q9Y5P4 10087 5q13.3 human S150-p 4777494 YSATSTSsFKKGHSL molecular association, regulation; activity, inhibited 28652409 0 3 3 reduced PtdIns(4)P binding affinity as well as low ceramide transfer activity, E494R/N495K/P535R/E537K mutations, recovery of both PtdIns(4)P binding and ceramide transfer activity. -CKAP2 CKAP2 Cell cycle regulation Q8WWK9 26586 13q14.3 human S628-p 7603500 FLTPVRRsRRLQEKT CKAP2_C intracellular localization 20458174 2 0 1 -cas9 Cas9 EC 3.1.-.- Q99ZW2 901176 bacteria K848-sm 1883443100 IVPQSFLkDDSIDNK HNH_4 protein stabilization; molecular association, regulation DNA(INDUCES) 35022246 1 1 0 -Krt8 K8 Cytoskeletal P11679 16691 15 F2|15 57.2 cM mouse S438-p 448540 SSYGGLTsPGFSYGM molecular association, regulation; intracellular localization cytoskeletal reorganization 10623656; 16563375 27 8 23 -DDX5 DDX5 EC 3.6.4.13; Helicase; Nuclear receptor co-regulator; Nucleolus; RNA splicing; RNA-binding; Spliceosome P17844 1655 17q23.3 human T446-p 15409321 GTAYTFFtPNNIKQV apoptosis, induced 23110695 1 2 4 -ACE2 ACE2 EC 3.4.17.23; Membrane protein, integral; Protease Q9BYF1 59272 Xp22.2 human K26-ub 1880091001 STIEEQAkTFLDKFN Peptidase_M2 protein degradation 35894122 1 1 0 -ABCA4 ABCA4 Membrane protein, integral; Membrane protein, multi-pass; Transporter; Transporter, ABC family P78363 24 1p22.1 human S1317-p 20940703 AGQTPQDsNVCSPGA enzymatic activity, induced 21721517 1 1 0 -Ulk1 ULK1 Autophagy; EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, Other; Protein kinase, Ser/Thr (non-receptor) O70405 22241 5|5 F mouse S638-p 2192504 DFPKTPSsQNLLTLL cell cycle regulation; autophagy, induced; cell growth, induced 32516310 2 9 4 -Zfp24 ZNF24 C2H2-type zinc finger protein; DNA-binding; Transcription factor Q91VN1 59057 18|18 A2 mouse S274-p 7320450 ILHQRIHsGEKPYGC molecular association, regulation cell differentiation, inhibited; transcription, inhibited DNA(DISRUPTS) 29786073 1 9 11 regulates oligodendrocyte differentiation and CNS myelination -Cited1 CITED1 Nuclear receptor co-regulator P97769 12705 X D|X 45.25 cM mouse S73-p 27937112 GSTSPIGsPTATPSS CITED intracellular localization cell differentiation, induced 23529225 1 0 0 S63/64/65/67/69/73/79/80/84A mutation in CITED1 inhibits its translocation into the nucleus and osteoblasts differentiation -Stat1 STAT1 DNA-binding; Transcription factor P42225 20846 1 C1.1|1 26.81 cM mouse S708-p 7723201 YIKTELIsVSEVHPS transcription, altered 17332413 2 2 0 -Rcan1 RCAN1 Inhibitor Q9JHG6 54720 16 C4|16 53.6 cM mouse T246-p 21511701 QTRRPEYtPIHLS__ molecular association, regulation RCAN1(INDUCES) 24021800 2 0 0 induces RCAN1 oligomers and insoluble aggregates -ARHGEF2 ARHGEF2 iso2 GEF; GEF, Rac/Rho; Motility/polarity/chemotaxis Q92974-2 9181 1q22 human T678-p 449343 PGVELLLtPREPALP activity, induced; intracellular localization 24356971 4 10 29 perinuclear localization, complement induced ARHGEF2 activation -APC APC Motility/polarity/chemotaxis; Tumor suppressor P25054 324 5q22.2 human S1279-p 450136 SRCSSLSsLSSAEDE APC_r molecular association, regulation transcription, altered CTNNB1(INDUCES) 11487578 1 0 0 -CRKL CRKL Adaptor/scaffold; Motility/polarity/chemotaxis P46109 1399 22q11.21 human Y207-p 447954 IPEPAHAyAQPQTTT molecular association, regulation; enzymatic activity, inhibited; activity, inhibited carcinogenesis, induced; cell growth, induced; apoptosis, inhibited; signaling pathway regulation PXN(DISRUPTS) 20697350; 22169110; 9710592 15 20 1215 Y207 is a negative regulatory phosphorylation site in CrkL; RAF-MEK-ERK pathway -Ezh2 EZH2 EC 2.1.1.43; METHYLTRANSFERASE; Methyltransferase; Methyltransferase, protein lysine Q61188 14056 6 B2.3|6 22.92 cM mouse Y696-p 463307 HSVNPNCyAKVMMVN SET molecular association, regulation; enzymatic activity, inhibited carcinogenesis, induced; cell growth, induced; apoptosis, inhibited; transcription, induced; signaling pathway regulation H3(DISRUPTS); POLR2A(INDUCES) 32461334 1 1 1 Regulation of Src/EZH2/c-Jun pathway; inhibits methyl transferase activity -CCKBR CCKBR GPCR, family 1; Membrane protein, integral; Membrane protein, multi-pass; Receptor, GPCR P32239 887 11p15.4 human S442-p 17825903 RLSYTTIsTLGPG__ molecular association, regulation ARRB1(INDUCES) 21156802 1 0 0 -Grin2a NMDAR2A Channel, ligand-gated; Membrane protein, integral; Membrane protein, multi-pass P35436 14811 16 A1|16 5.28 cM mouse S1459-p 481117 RVYKKMPsIESDV__ NMDAR2_C molecular association, regulation; receptor recycling, induced neural plasticity SNX27(INDUCES); PSD-95(DISRUPTS) 32877683 2 8 2 Regulates NMDAR interactions and trafficking -Pax5 PAX5 Oncoprotein Q02650 18507 4 B1|4 23.55 cM mouse Y102-p 34364233 VVEKIAEyKRQNPTM PAX protein degradation; ubiquitination carcinogenesis, inhibited; cell growth, inhibited; transcription, inhibited 36064939 1 0 1 -GCK GK Carbohydrate Metabolism - amino sugar and nucleotide sugar; Carbohydrate Metabolism - galactose; Carbohydrate Metabolism - glycolysis and gluconeogenesis; Carbohydrate Metabolism - starch and sucrose; EC 2.7.1.2; Kinase, other; Mitochondrial P35557 2645 7p13 human K459-sm 27581518 VSAVACKkACMLGQ_ protein stabilization; enzymatic activity, induced 23297408 1 1 0 -CFTR CFTR Channel, chloride; EC 3.6.3.49; Hydrolase; Membrane protein, integral; Membrane protein, multi-pass; Transporter; Transporter, ABC family P13569 1080 7q31.2 human K447-sm 52485001 VLKDINFkIERGQLL ABC_tran protein degradation; protein conformation 26627832 1 0 0 formation of a non-native formation of a non-native CFTR NBD1 protein conformation -H3C1 H3 DNA-binding P68431 8350 6p22.2 human K79-m1 459011 REIAQDFkTDLRFQS Histone molecular association, regulation chromatin organization, altered; transcription, inhibited L3MBTL iso4(INDUCES) 19805358; 23583077 16 21 41 regulates nucleosome dynamics -Hdac1 HDAC1 DEACETYLASE; Deacetylase; EC 3.5.1.98; Hydrolase; Nuclear receptor co-regulator O09106 433759 4 D2.2|4 63.26 cM mouse K432-ac 4219803 EEGEGGRkNSSNFKK acetylation; enzymatic activity, inhibited 19822520 2 0 0 inhibits activity of itself and of HDAC2 and hence results in increased histone acetylation -NR3C1 GR DNA-binding; Mitochondrial; Nuclear receptor; Transcription factor P04150 2908 5q31.3 human K494-ac 3287302 NLEARKTkKKIKGIQ receptor desensitization, induced; molecular association, regulation transcription, induced; transcription, inhibited NFkB-p65(DISRUPTS) DNA(DISRUPTS) 16380507; 19141540 2 0 0 -Wnk4 WNK4 EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, Other; Protein kinase, Ser/Thr (non-receptor) Q80UE6 69847 11|11 D mouse K238-ub 40323308 VRFYDSWkSVLRGQV Pkinase protein degradation 23576762 1 1 0 regulates electrolyte homeostasis and involved in Pseudohypoaldosteronism type II (PHAII) pathogenesis -Itgb4 ITGB4 Cell adhesion; Membrane protein, integral; Motility/polarity/chemotaxis; Receptor, misc. A2A863 192897 11 E2|11 80.91 cM mouse Y1560-p 456323 LLGYSVEyQLLNGGE fn3 apoptosis, induced; cytoskeletal reorganization; signaling pathway regulation 30187999 6 0 1 a6?4/FAK/p38 pathway regulation; increased desmin expression; podocyte injury; decreased WT1, synaptopodin expression -Ikzf1 Ikaros C2H2-type zinc finger protein; DNA-binding; Transcription factor Q03267 22778 11 A1|11 7.02 cM mouse T140-p 451354 MVHKRSHtERPFQCN transcription, altered 12464629 1 1 0 -CDC27 CDC27 Cell cycle regulation P30260 996 17q21.32 human S821-p 23010415 TQLHAAEsDEF____ molecular association, regulation MCPH1(INDUCES) 22139841 1 0 0 -TRPC3 TRPC3 iso3 Channel, cation; Membrane protein, integral; Membrane protein, multi-pass Q13507-3 7222 4q27 human T11-p 458335 SPSLRRMtVMREKGR activity, inhibited 14983059; 16331690 2 0 0 -Gabrg2 GABRG2 Channel, chloride; Channel, ligand-gated; Membrane protein, integral; Membrane protein, multi-pass; Transporter; Transporter, ion channel P22723 14406 11 A5|11 24.8 cM mouse Y413-p 455818 ERDEEYGyECLDGKD Neur_chan_memb activity, induced; receptor internalization, altered 19903874 7 0 0 spatial object recognition in mice -FHOD1 FHOD1 Actin-binding Q9Y613 29109 16q22.1 human S498-p 1984218 PAARTPQsPAPCVLL intracellular localization cytoskeletal reorganization 31794718 1 32 8 F-actin bundling and nuclear movement -TP63 p63 DNA-binding; Transcription factor Q9H3D4 8626 3q28 human Y290-p 10359106 RQSVLVPyEPPQVGT P53 protein stabilization 19783996 1 0 0 -TGFBR2 TGFBR2 EC 2.7.11.30; KINASE; Kinase, protein; Membrane protein, integral; Oncoprotein; Protein kinase, Ser/Thr (receptor); Protein kinase, TKL P37173 7048 3p24.1 human K556-ne 27581511 GRSCSEEkIPEDGSL protein stabilization; ubiquitination 23290524 1 0 0 antagonizes its ubiquitination -ELAVL1 HuR RNA-binding Q15717 1994 19p13.2 human T118-p 474554 SGLPRTMtQKDVEDM RRM_1 molecular association, regulation; intracellular localization RNA splicing, induced; RNA stability, induced; transcription, induced; RNA stability, altered p21Cip1(INDUCES) RNA(INDUCES) 17317627; 19528229; 21862584; 24865968; 24968827 6 0 3 regulates DUSP1 mRNA and protein expression -PXN PXN Adaptor/scaffold; Cell adhesion; Cytoskeletal; Motility/polarity/chemotaxis P49023 5829 12q24.23 human S258-p 465488 TQQQTRIsASSATRE molecular association, regulation TACE(DISRUPTS) 23317503 1 32 14 Inhibits lipid raft transfer -Scn10a SCN10A Channel, sodium; Membrane protein, integral; Membrane protein, multi-pass Q62968 rat S1452-p 25126701 NAMKKLGsKKPQKPI activity, induced 22426212 1 0 0 increase Channel function -RECQL4 RECQL4 EC 3.6.4.12; Helicase O94761 9401 8q24.3 human K385-ac 7106308 AWKQKWRkKGECFGG intracellular localization 19299466 1 0 0 accumulates in the cytoplasm -PA2G4 Ebp1 Nuclear receptor co-regulator; Nucleolus; Transcription, coactivator/corepressor Q9UQ80 5036 12q13.2 human K298-sm 11539304 MGVVECAkHELLQPF Peptidase_M24 sumoylation; protein stabilization; intracellular localization carcinogenesis, inhibited; cell growth, inhibited; transcription, inhibited 19946338 1 0 0 mutation of either site abolishes sumoylation at other site -GSK3B GSK3B EC 2.7.11.1; EC 2.7.11.26; KINASE; Kinase, protein; Protein kinase, CMGC; Protein kinase, Ser/Thr (non-receptor) P49841 2932 3q13.33 human S21-p 456055 CKPVQQPsAFGSMKV carcinogenesis, inhibited; apoptosis, induced 33755959 7 1 9 -Pxn PXN Adaptor/scaffold; Cell adhesion; Cytoskeletal; Motility/polarity/chemotaxis Q66H76 360820 12q16 rat Y31-p 448785 FLSEEPPySYPTGNH activity, induced; molecular association, regulation cell motility, altered DOCK1(INDUCES); CRK(INDUCES) 15308668 49 8 64 activation of Rac1 -EIF3A eIF3-theta RNA-binding; Translation; Translation initiation Q14152 8661 10q26.11 human S1364-p 487404 RAEKDREsLRRTKNE molecular association, regulation transcription, induced; translation, induced; signaling pathway regulation eIF4G(INDUCES) 30012863 1 3 37 PKC-Raf-ERK signaling -Met Met EC 2.7.10.1; KINASE; Kinase, protein; Membrane protein, integral; Oncoprotein; Protein kinase, TK; Protein kinase, tyrosine (receptor) P16056 17295 6 A2|6 7.83 cM mouse Y1354-p 448473 YVHVNATyVNVKCVA molecular association, regulation cell motility, altered; cytoskeletal reorganization GRB2(INDUCES); PIK3C2A(INDUCES); GAB1(INDUCES); SHC1(INDUCES) 10069803; 7708691 23 4 122 activates cell mobility -DNM1L DRP1 Apoptosis; EC 3.6.5.5; Endoplasmic reticulum; Hydrolase; Microtubule-binding; Mitochondrial; Motor O00429 10059 12p11.21 human K608-sm 9859920 LLAEEKSkPIPIMPA activity, induced; intracellular localization 19638400 1 0 0 sumoylation is linked to its GTPase activity cycle, and influenced by DRP1 localization -SMN1 SMN RNA processing; RNA-binding Q16637 6606 5q13.2 human S187-p 9316349 SDNIKPKsAPWNSFL SMN molecular association, regulation SIP1(DISRUPTS); GEMIN8(DISRUPTS) 21609790 1 5 0 -Kcnb1 Kv2.1 Channel, cation; Channel, ligand-gated; Channel, potassium; Membrane protein, integral; Membrane protein, multi-pass P15387 25736 3q42 rat S567-p 473554 LEMSSMPsPVAPLPA Kv2channel activity, inhibited 16917065 6 6 0 -LRRC8A LRRC8A Membrane protein, integral; Membrane protein, multi-pass Q8IWT6 56262 9q34.11 human S217-p 471190 PMLQRTKsRIEQGIV Pannexin_like activity, induced 34083438 1 28 8 -ADAM22 ADAM22 Cell adhesion; Membrane protein, integral; Motility/polarity/chemotaxis Q9P0K1 53616 7q21.12 human S857-p 469109 RFRPRSNsTETLSPA protein stabilization; molecular association, regulation; intracellular localization 14-3-3 beta(INDUCES); 14-3-3 theta(INDUCES); 14-3-3 zeta(INDUCES); 14-3-3 epsilon(INDUCES); 14-3-3 gamma(INDUCES); 14-3-3 eta(INDUCES) 16868027 2 15 74 -GATAD2A GATAD2A Transcription factor Q86YP4 54815 19p13.11 human K30-sm 3755612 DVESKKIkMERGLLA molecular association, regulation transcription, inhibited HDAC1(INDUCES) 16738318 1 0 0 -CDCA5 CDCA5 Cell cycle regulation Q96FF9 113130 11q13.1 human S21-p 3208968 RSGPRAPsPTKPLRR molecular association, regulation cell cycle regulation H2A.1(DISRUPTS); SMC3(DISRUPTS) 21878504 2 19 0 -CD6 CD6 Cell surface; Membrane protein, integral P30203 923 11q12.2 human S484-p 28095002 DSDSGSDsDYEHYDF phosphorylation signaling pathway regulation 23711376 1 0 0 ERK1/2 phosphorylation, MAPK pathway activation -RUNX1 AML1 DNA-binding; Oncoprotein; Transcription factor Q01196 861 21q22.12 human S266-p 454400 QYLGSIAsPSVHPAT activity, induced; molecular association, regulation; phosphorylation transcription, altered; cell growth, altered CBFB(INDUCES) 18695000; 8668214 7 3 28 -ZEB1 TCF8 C2H2-type zinc finger protein; DNA-binding; Motility/polarity/chemotaxis; Transcription, coactivator/corepressor P37275 6935 10p11.22 human S585-p 36552500 GDGNLSPsQPPLKNL protein stabilization DNA repair, induced 25086746 1 0 0 -PHF2 PHF2 DEMETHYLASE; Demethylase; EC 1.14.11.-; Nucleolus O75151 5253 9q22.31 human S899-p 4169511 RSKKRKGsDDAPYSP molecular association, regulation transcription, induced Mrf-2(INDUCES) DNA(INDUCES) 21532585 1 35 8 demethylation of Mrf-2 K336, complex is then targeted to promoters and removes repressive H3K9m2 -Pxn PXN Adaptor/scaffold; Cell adhesion; Cytoskeletal; Motility/polarity/chemotaxis Q8VI36 19303 5 F|5 56.1 cM mouse Y181-p 448898 PGALSPLyGIPENNT Paxillin apoptosis, inhibited 30604146 5 4 22 -TBCB TBCB Chaperone; Cytoskeletal; Motility/polarity/chemotaxis Q99426 1155 19q13.12 human S65-p 455784 GVDDKFYsKLDQEDA Ubiquitin_2 cytoskeletal reorganization 15831477; 18048340 2 0 0 -ATG13 ATG13 Autophagy; Vesicle O75143 9776 11p11.2 human S356-p 34499855 TETVSNSsEGRASPH carcinogenesis, inhibited; autophagy, induced; transcription, altered 34482636; 34604061; 35035775; 35182693 4 1 0 -MTF1 MTF1 C2H2-type zinc finger protein; Transcription factor Q14872 4520 1p34.3 human T254-p 25300735 RKHIRTHtGEKPFRC intracellular localization transcription, inhibited 24962574 1 0 2 -TNNI3 TNNI3 Actin-binding; Motility/polarity/chemotaxis; Motor P19429 7137 19q13.42 human S23-p 448423 PAPIRRRsSNYRAYA Troponin-I_N activity, induced; molecular association, regulation; activity, inhibited cytoskeletal reorganization TNNC1(DISRUPTS) 15134451; 24116014; 24585778; 27557662; 28018230; 8543035 68 11 11 increased myofilament length ; muscle contraction -Ctnnd1 CTNND1 Actin-binding; Adaptor/scaffold; Cell adhesion; G protein regulator, misc.; Motility/polarity/chemotaxis P30999 12388 2 D|2 49.45 cM mouse Y228-p 449648 YPGGSDNyGSLSRVT molecular association, regulation carcinogenesis, induced; cell growth, induced CDH1(INDUCES); RHOA(INDUCES) 17194753; 26067913 8 45 1087 -NINL Nlp Cell cycle regulation; Microtubule-binding Q9Y2I6 22981 20p11.21 human S448-p 15668107 QGYRERLsLLRSEVE intracellular localization cell cycle regulation 20864540 1 1 0 -LEPR LEPR Membrane protein, integral; Receptor, cytokine P48357 3953 1p31.3 human K891-ub 1872271905 AQGLNFQkPETFEHL receptor internalization, induced endocytosis, induced 16482222 1 0 0 -Hnf4a HNF4 alpha DNA-binding; Nuclear receptor; Transcription factor P49698 15378 2 H3|2 84.32 cM mouse S265-p 63076101 LAEMSRVsIRILDEL Hormone_recep molecular association, regulation SSU72(INDUCES) 34616001 2 1 0 -Aatk Lmr1 EC 2.7.11.1; KINASE; Kinase, protein; Membrane protein, integral; Protein kinase, Ser/Thr (non-receptor); Protein kinase, TK; Protein kinase, tyrosine (receptor) Q80YE4 11302 11|11 E2 mouse S606-p 456514 HSHRRQGsPCPSRSP apoptosis, induced 16100393 1 0 0 -CASP8 CASP8 Apoptosis; EC 3.4.22.61; Protease Q14790 841 2q33.1 human S305-p 31894302 IYQLMDHsNMDCFIC Peptidase_C14 protein processing apoptosis, inhibited 24484936 1 0 0 -EIF2AK2 PKR EC 2.7.10.2; EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, Other; Protein kinase, Ser/Thr (non-receptor); Protein kinase, tyrosine (non-receptor); Translation P19525 5610 2p22.2 human Y293-p 458273 HRIDGKTyVIKRVKY Pkinase enzymatic activity, induced translation, altered; cell growth, altered 16373505 1 0 0 -Pkd2 PKD2 Channel, cation; Membrane protein, integral; Membrane protein, multi-pass O35245 18764 5 E5|5 50.68 cM mouse S827-p 4696848 HSSRRRGsISSGVSY activity, inhibited 22518003 3 5 0 Negative regulation of flow-induced Ca2+ entry -Slc6a5 SLC6A5 Membrane protein, integral; Membrane protein, multi-pass; Transporter; Transporter, SLC family P58295 171148 1q22 rat K773-ub 31914107 QHRGERYkNMIDPLG protein degradation; ubiquitination; intracellular localization endocytosis, induced; transcription, altered 23484054; 31628376 2 0 0 LNX2 mediated degradation was slower and seen after 48 hours, PKC regulation of SLC6A5 activity, modulation in the glycine transport activity of SLC6A5 -INCENP INCENP iso2 Cell cycle regulation; EC 2.7.11.1 Q9NQS7-2 3619 11q12.3 human R887-m1 50613405 SKPRYHKrTSSAVWN cell cycle regulation; cell growth, induced 26460953 1 1 0 growth of cancer cells -Hcn2 HCN2 Channel, cation; Membrane protein, integral; Membrane protein, multi-pass O88703 15166 10|10 C1 mouse K669-sm 63108401 AIIQEIVkYDREMVQ activity, induced 28127275 1 0 0 increases HCN2 channel surface expression and In G-max -Scn2a SCN2A Channel, sodium; Membrane protein, integral; Membrane protein, multi-pass P04775 24766 3q21 rat S554-p 452015 TYEKRFSsPHQSLLS activity, inhibited 12359152 2 8 2 -BECN1 beclin 1 Adaptor/scaffold; Autophagy; Membrane protein, peripheral Q14457 8678 17q21.31 human S295-p 27156801 FRLGRLPsVPVEWNE APG6 molecular association, regulation; intracellular localization; activity, inhibited cell cycle regulation; carcinogenesis, induced; autophagy, inhibited 14-3-3 beta(INDUCES); K18(INDUCES); Vimentin(INDUCES); PIK3C3(INDUCES) 23112296; 34077419 4 0 0 -SPTLC2 SPTLC2 EC 2.3.1.50; Lipid Metabolism - sphingolipid; Membrane protein, integral; Transferase O15270 9517 14q24.3 human S384-p 38520203 FTKSFGAsGGYIGGK Aminotran_1_2 enzymatic activity, induced 25567748 1 0 0 -PXN PXN iso2 Adaptor/scaffold; Cell adhesion; Cytoskeletal; Motility/polarity/chemotaxis P49023-2 5829 12q24.23 human S272-p 465466 ELDELMAsLSDFKFM molecular association, regulation; intracellular localization cell motility, altered; cytoskeletal reorganization; cell adhesion, altered GIT1(INDUCES); GIT1(DISRUPTS); ARHGEF6(INDUCES) 16717130; 18664639; 18676874; 18986306; 20406887 12 12 0 critical for OxPAPC-induced pulmonary endothelial barrier protection; mediates focal-adhesion disassembly -MACF1 ACF7 Actin-binding; Cytoskeletal; Motility/polarity/chemotaxis Q9UPN3 23499 1p34.3 human S7318-p 18507010 RPGSRAGsRAGSRAS intracellular localization cell motility, induced; cytoskeletal reorganization 21295697 1 2 0 inhibits localization along microtubules, alters organization of microtubules, regulates skin wound repair, SC migration -MTOR mTOR Autophagy; EC 2.7.11.1; KINASE; Kinase, protein; Motility/polarity/chemotaxis; Protein kinase, Ser/Thr (non-receptor); Protein kinase, atypical P42345 2475 1p36.22 human S2159-p 20473601 RIQSIAPsLQVITSK molecular association, regulation; enzymatic activity, induced; phosphorylation cell cycle regulation; cell growth, induced; transcription, induced; signaling pathway regulation Raptor(DISRUPTS) 21576368; 33411856 3 1 1 phosphorylation increases the sensitivity and duration of insulin-stimulated mTORC1 signaling; Increased phosphorylation of itself at S2481 and of S6K1 and 4EBP1; induces autophosphorylation of itself, promotes mTORC1 signaling -Ulk1 ULK1 Autophagy; EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, Other; Protein kinase, Ser/Thr (non-receptor) O70405 22241 5|5 F mouse K606-ac 27850503 RPLRGSPkLPDFLQR enzymatic activity, induced autophagy, induced 22717509 2 1 0 -EGFR EGFR EC 2.7.10.1; KINASE; Kinase, protein; Membrane protein, integral; Oncoprotein; Protein kinase, TK; Protein kinase, tyrosine (receptor) P00533 1956 7p11.2 human K757-ub 1065308 ATSPKANkEILDEAY PK_Tyr_Ser-Thr receptor recycling, inhibited; protein degradation 16543144; 17940017 2 4 0 -PTK2 FAK EC 2.7.10.2; KINASE; Kinase, protein; Protein kinase, TK; Protein kinase, tyrosine (non-receptor) Q05397 5747 8q24.3 human Y577-p 447890 YMEDSTYyKASKGKL PK_Tyr_Ser-Thr enzymatic activity, induced; phosphorylation carcinogenesis, induced; cell differentiation, altered; cell growth, induced; cell motility, induced; cytoskeletal reorganization; cell adhesion, altered; transcription, altered 15735019; 17088251; 18437915; 23716717; 35999654 88 40 1747 -H3C14 HIST2H3A/C/D DNA-binding Q71DI3 126961 1q21.2 human K23-ac 18465114 PRKQLATkAARKSAP Histone chromatin organization, altered; transcription, induced 20075197 1 5 63 -Crtc2 TORC2 Transcription, coactivator/corepressor Q3U182 74343 3|3 F1 mouse S70-gl 10902812 RSSHYGGsLPNVNQI TORC_N activity, induced; molecular association, regulation; intracellular localization; phosphorylation 14-3-3 beta(DISRUPTS) 18323454 1 1 0 inhibits phosphorylation of its own site -TUBB3 TUBB3 Cytoskeletal; Motility/polarity/chemotaxis Q13509 10381 16q24.3 human Y340-p 464858 IQSKNSSyFVEWIPN Tubulin_C protein stabilization; intracellular localization cytoskeletal reorganization 35631517 1 18 369 -COP1 COP1 EC 6.3.2.-; EC 6.3.2.19; Ligase; UBIQUITIN LIGASE; Ubiquitin conjugating system; Ubiquitin ligase Q8NHY2 64326 1q25.1-q25.2 human K294-ac 1881312002 SVLEEDIkRVEEMSG protein degradation cell growth, induced; apoptosis, inhibited 33995658 1 0 0 decreases ?-catenin protein degradation and enhances ?-catenin stability, MYST3 regulates apoptosis by COP1 acetylation and stabling ?-catenin -Aicda AID EC 3.5.4.38; Hydrolase Q9WVE0 11628 6|6 F1 mouse S3-p 20660600 _____MDsLLMKQKK activity, inhibited 21135131 2 0 0 decreased class switching, decreased hypermutation, and decreased translocation frequency -SPIN1 SPIN1 DNA-binding; Nucleolus Q9Y657 10927 9q22.1 human S109-p 24976101 LNKDERVsALEVLPD molecular association, regulation carcinogenesis, induced; cell growth, induced; transcription, induced; signaling pathway regulation TCF4(INDUCES) 22258766 1 0 0 induces WNT/TCF signaling -ETV6 Tel DNA-binding; Motility/polarity/chemotaxis; Oncoprotein; Transcription factor P41212 2120 12p13.2 human Y314-p 454814 SHREDLAyMNHIMVS activity, induced; molecular association, regulation GRB2(INDUCES) 12149229 1 1 1 RAS activation -Rptor Raptor Adaptor/scaffold Q8K4Q0 74370 11|11 E2 mouse K840-ac 50792300 VLNSIAYkATVNARP phosphorylation transcription, altered; signaling pathway regulation 26357899 1 1 0 induces S792 phosphorylation; inhibits mTORC1 signaling -Prkd1 PRKD1 Autophagy; EC 2.7.11.13; KINASE; Kinase, protein; Motility/polarity/chemotaxis; Protein kinase, CAMK; Protein kinase, Ser/Thr (non-receptor) Q9WTQ1 85421 6q22 rat S748-p 448590 GEKSFRRsVVGTPAY Pkinase enzymatic activity, induced 11410586 56 49 53 -ESR2 ER-beta DNA-binding; Nuclear receptor Q92731 2100 14q23.2-q23.3 human S87-p 447915 WPTPGHLsPLVVHRQ ERbeta_N activity, induced 15862947 3 0 0 -Myocd myocardin Cell development/differentiation; Transcription factor Q8VIM5 214384 11|11 B3 mouse S462-p 3627507 TSSSPPIsPASSDLS transcription, inhibited 16141410 1 0 0 -Tom1l1 Srcasm Adaptor/scaffold Q923U0 71943 11 D|11 55.47 cM mouse Y441-p 451209 DLQPPNYyEVMEFDP molecular association, regulation cell growth, altered PIK3R1(INDUCES) 11711534; 17046829 2 1 5 mutation of this site promotes hyperproliferative phenotype -TRPV4 TRPV4 Channel, cation; Membrane protein, integral; Membrane protein, multi-pass Q9HBA0 59341 12q24.11 human S189-p 10272404 DEEFREPsTGKTCLP activity, induced 19661060 1 0 0 -FGFR3 FGFR3 EC 2.7.10.1; KINASE; Kinase, protein; Membrane protein, integral; Protein kinase, TK; Protein kinase, tyrosine (receptor) P22607 2261 4p16.3 human Y770-p 2036700 LSAPFEQySPGGQDT cell growth, altered 11294897 1 0 0 Y770F mutation increases the transforming activity of FGFR3 -PAK2 PAK2 EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, STE; Protein kinase, Ser/Thr (non-receptor) Q13177 5062 3q29 human T169-p 471473 TEAPAVVtEEEDDDE phosphorylation cell cycle regulation; carcinogenesis, induced; cell growth, induced; signaling pathway regulation 32483448 1 30 15 induces phosphorylation of mEK and ERK, induces MAPK signaling pathway -VIM Vimentin Cytoskeletal; Motility/polarity/chemotaxis P08670 7431 10p13 human S55-p 476052 TSRSLYAsSPGGVYA Filament_head molecular association, regulation cytoskeletal reorganization IDE(INDUCES) 19584300 4 23 30 intermediate filament disassembly -Ahrr AHRR Transcription factor Q3U1U7 11624 13|13 C1 mouse K660-sm 6423502 DCRAPIVkREPLDSP molecular association, regulation transcription, inhibited ANKRA2(INDUCES); HDAC5(INDUCES); HDAC4(INDUCES) 19251700 1 2 0 -Gja1 GJA1 Channel, misc.; Membrane protein, integral; Membrane protein, multi-pass; Motility/polarity/chemotaxis P23242 14609 10 B4|10 28.64 cM mouse S325-p 449992 NRMGQAGsTISNSHA Connexin43 molecular association, regulation; intracellular localization cytoskeletal reorganization; signaling pathway regulation; endocytosis, inhibited TUBB(INDUCES) 16882687; 21527737; 31189653; 36206047 10 14 0 -FHL2 FHL2 Motility/polarity/chemotaxis; Nuclear receptor co-regulator; Transcription, coactivator/corepressor Q14192 2274 2q12.2 human Y176-p 23106943 ITTGGVTyREQPWHK LIM cell cycle regulation; cell growth, inhibited 33932144 1 1 6 -TRIM29 TRIM29 Transcription factor; UBIQUITIN LIGASE; Ubiquitin ligase Q14134 23650 11q23.3 human K116-ac 13362607 LQLGAAKkPPVTFAE molecular association, regulation cell cycle regulation; carcinogenesis, induced; apoptosis, inhibited; transcription, inhibited p53(INDUCES) 20368352 1 1 0 interaction of TRIM29 with p53 inhibits p53 binding to p21 promoter -RAF1 RAF1 EC 2.7.11.1; KINASE; Kinase, protein; Oncoprotein; Protein kinase, Ser/Thr (non-receptor); Protein kinase, TKL P04049 5894 3p25.2 human S471-p 456813 IIHRDMKsNNIFLHE PK_Tyr_Ser-Thr molecular association, regulation; enzymatic activity, induced MEK1(INDUCES) 16093354; 18775988 2 2 0 -Grm5 mGluR5 iso2 GPCR, family 3; Membrane protein, integral; Membrane protein, multi-pass; Receptor, GPCR P31424-2 24418 1q32 rat S901-p 4213805 QHLWQRLsVHINKKE receptor internalization, induced; protein degradation; molecular association, regulation; intracellular localization endocytosis, induced Calmodulin(DISRUPTS) 18715999; 23152621; 36087841 3 0 1 -H4c2 H4 DNA-binding P62806 326620 13|13 A3.1 mouse K20-m2 465128 GGAKRHRkVLRDNIQ CENP-T_C chromatin organization, altered 19434510 30 16 1 regulation of senescence-related epigenetics modification -Ptpn2 PTPN2 EC 3.1.3.48; Motility/polarity/chemotaxis; PHOSPHATASE; Protein phosphatase, tyrosine (non-receptor) Q06180 19255 18|18 E1 mouse S304-p 451134 LSPICDHsQNRVMVE phosphorylation; enzymatic activity, induced carcinogenesis, induced; apoptosis, inhibited 37000627 2 33 15 dephosphorylates CD3Z -LAT2 LAB Adaptor/scaffold; Membrane protein, integral Q9GZY6 7462 7q11.23 human Y193-p 450645 EDEESEDyQNSASIH LAT2 molecular association, regulation cell differentiation, altered GRB2(INDUCES); PLCG1(INDUCES) 14722116; 17993265 3 8 151 -HNRNPK hnRNP K RNA splicing; RNA-binding; Spliceosome P61978 3190 9q21.32 human S284-p 448185 RRDYDDMsPRRGPPP molecular association, regulation; intracellular localization translation, altered; cell growth, induced; transcription, induced; transcription, inhibited PPP1CA(INDUCES); TDP-43(INDUCES) 11231586; 16564677; 24236111; 25410660; 26804170 7 102 184 localized to nuclear matrix -MAVS MAVS Adaptor/scaffold; Membrane protein, integral Q7Z434 57506 20p13 human T328-gl 1872691003 TVPSKLPtSSKPPGA phosphorylation 31461653 1 1 0 positively regulates phosphorylation of S442 (data from MAVS 7A mutant) -Pdk1 PDHK1 EC 2.7.11.2; KINASE; Kinase, protein; Mitochondrial; Protein kinase, Ser/Thr (non-receptor); Protein kinase, atypical Q8BFP9 228026 2|2 C3 mouse Y136-p 11057941 AEDAKTIyEFTDTVI BCDHK_Adom3 molecular association, regulation cell growth, induced DLAT(INDUCES) 22195962 1 0 3 Y to F mutants show decreased proliferation under hypoxia and increased oxidative phosphorylation. -EPB41 EPB41 iso4 Cytoskeletal P11171-4 2035 1p35.3 human S312-p 455112 QAQTRQAsALIDRPA FA molecular association, regulation; protein conformation cytoskeletal reorganization XK(INDUCES); SPTA1(DISRUPTS); DARC(INDUCES); GPC1(INDUCES) 21542582 2 5 4 interactions are induced by phosphorylation of either of the sites -Dck DCK EC 2.7.1.74; Kinase, other; Nucleotide Metabolism - purine; Nucleotide Metabolism - pyrimidine P43346 13178 5|5 E1 mouse S74-p 456305 EFEELTTsQKSGGNV dNK activity, induced; enzymatic activity, induced DNA repair, induced; signaling pathway regulation 25101980 16 28 92 Salvage pathway, induce dCTP production, pool size and influences in T-cell development.Regulation of genome stability -DOK1 DOK1 Adaptor/scaffold; Motility/polarity/chemotaxis Q99704 1796 2p13.1 human Y362-p 448367 DPKEDPIyDEPEGLA protein degradation; molecular association, regulation; ubiquitination; activity, inhibited; phosphorylation signaling pathway regulation CBLL1(INDUCES); RASA1(INDUCES); NCK1(INDUCES) 11551902; 22252131; 34145060 9 27 497 regulates TCR/CD28 signaling -Bmpr1a BMPR1A EC 2.7.11.30; KINASE; Kinase, protein; Membrane protein, integral; Protein kinase, Ser/Thr (receptor); Protein kinase, TKL P36895 12166 14 B|14 20.81 cM mouse Y453-p 3712679 TGGIVEEyQLPYYNM PK_Tyr_Ser-Thr molecular association, regulation cell growth, induced; signaling pathway regulation BMPR2(INDUCES); TAB1(DISRUPTS) 22729085 1 1 0 regulation of BMP downstream pathways-Erk1/2 and Smad1 activation, regulates life span of osteoblasts (expansion) -LIG1 LIG1 DNA repair, damage; EC 6.5.1.1; Ligase P18858 3978 19q13.33 human K192-ub 59175204 PKPLKTSkAETPTES protein degradation 27573245 1 1 0 -ESRRA ERR1 DNA-binding; Nuclear receptor; Transcription regulation P11474 2101 11q13.1 human K162-ac 15211511 RGGRQKYkRRPEVDP molecular association, regulation transcription, inhibited DNA(DISRUPTS) 20484414 1 0 0 -Stat1 STAT1 DNA-binding; Transcription factor P42225 20846 1 C1.1|1 26.81 cM mouse K379-ub 27211085 NTVKGFRkFNILGTH STAT_bind molecular association, regulation transcription, inhibited DNA(DISRUPTS) 29242538 1 4 0 ubiquitylation promotes dephosphorylation of STAT1/STAT2, and negatively regulates antiviral responses -Notch1 Notch 1 Membrane protein, integral; Motility/polarity/chemotaxis; Oncoprotein; Receptor, misc.; Transcription factor Q01705 18128 2 A3|2 18.91 cM mouse R2262-m2 56852001 AFEPPPPrLSHLPVA activity, induced; protein degradation; ubiquitination transcription, induced 25805888 1 1 0 -Sp1 SP1 C2H2-type zinc finger protein; DNA-binding; Transcription factor Q01714 24790 7q36 rat T454-p 448226 SGPIIIRtPTVGPNG transcription, induced 21115498 7 0 0 induced by carbon monoxide -EIF4ENIF1 4E-T Karyopherin; Nuclear import; Translation Q9NRA8 56478 22q12.2 human S752-p 26392102 PSADRDSsPTTNSKL molecular association, regulation 4E-T(INDUCES) 22966201 1 4 0 required for processing bodies (PBs or P bodies) assembly -VIL1 Villin Actin-binding; Motility/polarity/chemotaxis P09327 7429 2q35 human Y256-p 454007 LKAALKLyHVSDSEG molecular association, regulation; intracellular localization cytoskeletal reorganization ACTB(INDUCES) 12269817; 15342783 2 0 0 -YY1 YY1 C2H2-type zinc finger protein; Cell development/differentiation; Transcription factor P25490 7528 14q32.2 human T378-p 1218234 RTHVRIHtGDRPYVC molecular association, regulation; intracellular localization DNA(DISRUPTS) 19793915 1 11 38 in mitotic cells -ARHGAP24 ARHGAP24 GAP; GAP, Rac/Rho; Motility/polarity/chemotaxis Q8N264 83478 4q21.23-q21.3 human S437-p 12518706 SGIVTNGsFSSSNAE activity, induced cytoskeletal reorganization 16862148 1 3 0 membrane blebbing -SNPH syntaphilin iso2 Membrane protein, integral; Vesicle O15079-2 9751 20p13 human S59-p 50800758 SRRTSAGsRRRTSPP cell growth, induced 34087103 1 2 0 -MEF2A MEF2A DNA-binding; Motility/polarity/chemotaxis; Transcription factor Q02078 4205 15q26.3 human K403-sm 1922100 TNQNISIkSEPISPP cell differentiation, induced; transcription, inhibited 16484498; 16563226 2 0 0 -AXIN2 axin 2 Adaptor/scaffold Q9Y2T1 8313 17q24.1 human S311-p 53439300 SDALTDDsMSMTDSS protein degradation; protein stabilization; phosphorylation cell cycle regulation; carcinogenesis, inhibited; cell growth, inhibited; transcription, inhibited; signaling pathway regulation 26438599 1 0 0 Negatively regulates Wnt/beta-catenin pathway, increase binding between GSK3beta and beta-catenin, induces phosphorylation and degradation of beta-catenin, and inhibits Cdc20-mediated degradation of axin2 -MYB Myb DNA-binding; Oncoprotein; Transcription factor P10242 4602 6q23.3 human K503-sm 486351 EDLQDVIkQESDESG Cmyb_C intracellular localization transcription, inhibited 12631292 5 0 0 -PSIP1 LEDGF Motility/polarity/chemotaxis; Transcription, coactivator/corepressor O75475 11168 9p22.3 human K250-sm 13875712 KPRKEPDkKEGKKEV protein degradation transcription, inhibited 20382164 1 0 0 -GSK3B GSK3B EC 2.7.11.1; EC 2.7.11.26; KINASE; Kinase, protein; Protein kinase, CMGC; Protein kinase, Ser/Thr (non-receptor) P49841 2932 3q13.33 human Y216-p 448569 RGEPNVSyICSRYYR Pkinase protein stabilization; molecular association, regulation; intracellular localization; protein conformation; phosphorylation; enzymatic activity, induced apoptosis, altered; carcinogenesis, inhibited; apoptosis, induced; cell motility, inhibited; transcription, induced; transcription, altered; cell growth, altered TCF4(INDUCES); axin 1(DISRUPTS) 10995469; 12522140; 12900420; 14561750; 15020233; 17188038; 17318191; 18701488; 18949077; 21105670; 26755559; 33388549; 33829789; 33890983; 34966427; 35339896 98 128 4206 regulates localization and degradation of Snail -Ldb3 LDB3 Cytoskeletal Q9JKS4 24131 14|14 B mouse S296-p 28850313 EEALRRSsTPIEHAP phosphorylation cytoskeletal reorganization; signaling pathway regulation 23996002 1 0 0 facilitated PKA-mediated phosphorylation, sarcomere signaling center -HDAC4 HDAC4 DEACETYLASE; Deacetylase; EC 3.5.1.98; Hydrolase; Nuclear receptor co-regulator; SUMO LIGASE P56524 9759 2q37.3 human K559-sm 2793919 AQAGVQVkQEPIESD protein degradation; acetylation; ubiquitination; enzymatic activity, induced apoptosis, inhibited; transcription, inhibited 12032081; 25475100 2 1 0 -HNRNPL hnRNP L RNA splicing; RNA-binding P14866 3191 19q13.2 human Y359-p 473633 HRRGPSRyGPQYGHP RRM_5 protein stabilization; intracellular localization translation, induced; translation, inhibited hnRNP A2/B1(INDUCES) 23976881; 28520992 2 2 13 -HIF1A HIF1A Autophagy; DNA-binding; Transcription factor Q16665 3091 14q23.2 human K674-ac 14790000 ASPNRAGkGVIEQTE molecular association, regulation carcinogenesis, induced; transcription, induced p300(INDUCES) 20620956 3 2 0 -CTCF CTCF C2H2-type zinc finger protein; Transcription factor; Tumor suppressor Q08705 396274 chicken S612-p 448305 KKEDSSDsEENAEPD activity, inhibited transcription, induced; transcription, altered; cell growth, altered 11238955; 15733852 2 8 0 Phosphorylation mutant S612A inhibited transcriptional repression of transcription (CAT activity than wild-type CTCF. Phosphorylation mutant S612A showed transcriptional repression (CAT activity) not significantly different from wild-type after co-transfection with CK2. S612A also did not significanty alter growth suppression of COS7 cells in comparison with wild-type. -NEK9 NEK9 Autophagy; EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, Other; Protein kinase, Ser/Thr (non-receptor) Q8TD19 91754 14q24.3 human S944-p 4272073 GQQVGMHsKGTQTAK molecular association, regulation; enzymatic activity, induced signaling pathway regulation LC8(DISRUPTS); NEK6(INDUCES) 21454704; 23482567 2 11 0 -HSP90AA1 HSP90A Chaperone; Heat shock protein P07900 3320 14q32.31 human S595-p 31909111 VSNRLVTsPCCIVTS HSP90 activity, induced; molecular association, regulation; protein stabilization; activity, inhibited cell cycle regulation; carcinogenesis, induced; autophagy, inhibited; transcription, inhibited; signaling pathway regulation HSP90A(DISRUPTS); HSP70(DISRUPTS); P38G(INDUCES); TFEB(DISRUPTS); KRas(INDUCES) 24962213; 35941759 2 3 0 -BRAF BRAF EC 2.7.11.1; KINASE; Kinase, protein; Oncoprotein; Protein kinase, Ser/Thr (non-receptor); Protein kinase, TKL P15056 673 7q34 human T753-p 460657 YACASPKtPIQAGGY molecular association, regulation cell growth, altered RAF1(DISRUPTS) 16508002; 19933846 4 8 3 -ZAP70 ZAP70 EC 2.7.10.2; KINASE; Kinase, protein; Protein kinase, TK; Protein kinase, tyrosine (non-receptor) P43403 7535 2q11.2 human Y319-p 447587 TSVYESPySDPEELK activity, induced; molecular association, regulation; protein conformation; enzymatic activity, induced; phosphorylation transcription, induced; signaling pathway regulation; transcription, altered PLCG1(INDUCES); CD3G(DISRUPTS); Lck(INDUCES) 10037717; 10202147; 10318843; 11046020; 12648457; 26237552; 30992398; 33482200; 33531381; 34161759; 35259248 58 7 263 induces LAT phosphorylation, induces Erk and calcium signaling; induces TCR signaling; regulates TCR signaling -Oprd1 DOR-1 GPCR, family 1; Membrane protein, integral; Membrane protein, multi-pass; Receptor, GPCR P32300 18386 4 D2.3|4 64.78 cM mouse T352-p 18321900 LRRPRQAtTRERVTA intracellular localization 21220103 1 0 0 -Mlxipl ChREBP Transcription factor Q8VIP2 171078 12q12 rat S568-p 451262 TLLRPPEsPDAVPEI activity, inhibited transcription, inhibited DNA(DISRUPTS) 11724780 1 5 0 -COPS6 COPS6 Cell cycle regulation Q7L5N1 10980 7q22.1 human S60-p 27166600 DHWIRMRsQEGRPVQ JAB protein stabilization; ubiquitination cell growth, induced 23095642; 23421998; 26318036 3 0 0 phosphorylation of tis site stabilize COP56 , which in turn helps to stabilize E6AP protein/downregulates p53/promotes tumorigenesis; involved in p57 degradation; Akt phosphorylation of S60 reduced ubiquitination of COPS6. S60D mutant induces p53 degradation and enhances transformation. -LCP1 L-plastin Actin-binding; Motility/polarity/chemotaxis P13796 3936 13q14.13 human S5-p 450852 ___MARGsVSDEEMM molecular association, regulation; intracellular localization; enzymatic activity, induced carcinogenesis, induced; cell motility, induced; cell adhesion, induced; cytoskeletal reorganization; cell adhesion, altered ITGB2(NOT_REPORTED); ITGB2(INDUCES); ACTA1(INDUCES) 10446213; 16636079; 17294403; 20169155; 23001012; 26631483; 33449151; 33618712 15 49 4 induces MMP-9 activity -NR4A2 NR4A2 DNA-binding; Nuclear receptor P43354 4929 2q24.1 human K558-sm 7435500 YLSKLLGkLPELRTL Hormone_recep transcription, inhibited 19345186 1 0 0 -EGFR EGFR EC 2.7.10.1; KINASE; Kinase, protein; Membrane protein, integral; Oncoprotein; Protein kinase, TK; Protein kinase, tyrosine (receptor) P00533 1956 7p11.2 human Y1092-p 448057 TFLPVPEyINQSVPK protein degradation; molecular association, regulation; phosphorylation; enzymatic activity, induced; activity, induced; ubiquitination; intracellular localization; receptor internalization, altered; protein conformation cell cycle regulation; cell differentiation, inhibited; carcinogenesis, induced; carcinogenesis, inhibited; cell motility, induced; transcription, induced; transcription, altered; signaling pathway regulation; exocytosis, induced; cell growth, induced; apoptosis, inhibited; cell adhesion, altered; cell growth, altered RASA1(INDUCES); GRB2(INDUCES); Src(INDUCES); SHP-1(INDUCES); SOS1(INDUCES); EGFR(INDUCES); STAT3(INDUCES); CBL(INDUCES) DNA(INDUCES) 10069801; 11983694; 12631709; 12842895; 12873986; 1314835; 15192046; 15592458; 15618223; 16037379; 16729043; 2022651; 2022652; 21787862; 24430869; 26290602; 31952541; 32019812; 3263271; 33574089; 33707748; 33889303; 33947961; 34088769; 34107301; 34290403; 34367939; 34385595; 34469737; 34539858; 35157848; 35173310; 35226996; 36744428; 36988334; 7506413; 7741752; 8408058; 8490966; 8910327; 9733788 177 30 352 EGFR autophosphorylation sites modulate STAT activation. -HIPK2 HIPK2 EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, CMGC; Protein kinase, Ser/Thr (non-receptor) Q9H2X6 28996 7q34 human T880-p 29668000 QTIVIPDtPSPTVSV protein stabilization; molecular association, regulation; protein conformation; phosphorylation; enzymatic activity, induced apoptosis, induced PIN1(INDUCES) 24145406 1 0 0 -PLAGL2 PLAGL2 C2H2-type zinc finger protein; DNA-binding Q9UPG8 5326 20q11.21 human K250-ac 483054 SQELLKIkTEPVDML sumoylation transcription, induced 17551969 1 0 0 acetylation abolishes sumoylation on the same three residues, promoter-specific transcription -CHEK2 Chk2 EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, CAMK; Protein kinase, Ser/Thr (non-receptor); Tumor suppressor O96017 11200 22q12.1 human Y390-p 17534901 TLCGTPTyLAPEVLV Pkinase intracellular localization; enzymatic activity, induced 20713355 1 1 0 chromatin targeting of S372, S379, T389, singly and T383/389, T378/S379 -Zc3h12a MCPIP1 EC 3.1.-.-; Hydrolase Q5D1E7 230738 4|4 D2.2 mouse S435-p 22730005 TSQECLDsGIGSLES protein degradation; molecular association, regulation; ubiquitination; phosphorylation RNA stability, induced; transcription, induced BTRC(INDUCES) 22037600; 31072819 2 0 0 phosphorylation followed by degradation of ZC3H12A (aka regnase-1) augments IL-6 mRNA stability; induces phosphorylation of STAT3 -Stk11 LKB1 Autophagy; EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, CAMK; Protein kinase, Ser/Thr (non-receptor); Tumor suppressor Q9WTK7 20869 10|10 C1 mouse T366-p 448151 IEDGIIYtQDFTVPG protein degradation apoptosis, inhibited; DNA repair, altered 25329316; 28652249 6 0 0 improved survival of LKB1-deficient H2030 NSCLC cells to combined AZD1775 + cisplatin treatment -CENPT CENPT DNA replication Q96BT3 80152 16q22.1 human T11-p 12667377 HNPDSDStPRTLLRR CENP-T_N molecular association, regulation; intracellular localization cell cycle regulation 21529714; 25660545 3 2 0 localization of Ndc80/Hec1, controls kinetochore assembly, increases cell viability; KMN network recruitment -FBXL20 FBXL20 UBIQUITIN LIGASE; Ubiquitin ligase Q96IG2 84961 17q12 human S139-p 1875005600 DATCTSLsKFCSKLR protein degradation; molecular association, regulation carcinogenesis, inhibited; cell growth, inhibited; apoptosis, induced FBXO31(INDUCES) 34587475 1 0 0 -Casp4 CASP4 Apoptosis; EC 3.4.22.64; Protease P70343 12363 9 A1|9 2.46 cM mouse K159-ub 1877676802 NFDIIGMkGLLEDLG Peptidase_C14 protein degradation 30816303 1 0 0 -ACTN4 ACTN4 Cytoskeletal; Motility/polarity/chemotaxis O43707 81 19q13.2 human Y13-p 397383605 AANQSYQyGPSSAGN molecular association, regulation cell motility, inhibited ACTB(DISRUPTS) 29274473 1 0 0 slightly decreases binding; enhances invasion of melanoma cell line; decreases the susceptibility to m-calpain cleavage -Tbx21 TBX21 DNA-binding; Transcription factor Q9JKD8 57765 11|11 D mouse S498-p 56676120 DTKRRRIsPYPSSGD cell growth, inhibited; transcription, induced 29133416 1 1 0 IFN? transcription, attenuates colon cancer metastasis in RSK2 KO mice -FLOT2 FLOT2 Cell adhesion Q14254 2319 17q11.2 human Y163-p 475941 DVYDKVDyLSSLGKT Band_7 endocytosis, altered 19258392 4 3 36 regulates FLOT2 internalization -SAV1 SAV1 Adaptor/scaffold Q9H4B6 60485 14q22.1 human Y273-p 1870435804 CAPSVPRyDQPPPVT molecular association, regulation; protein conformation; phosphorylation signaling pathway regulation DDN(INDUCES); SAV1(DISRUPTS); MST1(DISRUPTS) 32905778 1 0 0 inhibits LATS1 phosphorylation, regulates Hippo signaling pathway -MCM4 MCM4 DNA replication; EC 3.6.4.12 P33991 4173 8q11.21 human T7-p 450000 _MSSPAStPSRRGSR activity, inhibited 12714602 2 3 0 -Lpin1 LPIN1 EC 3.1.3.4; Phosphatase, lipid Q91ZP3 14245 12 A1.1|12 7.9 cM mouse S106-p 471342 IPMYLATsPILSEGA Lipin_N intracellular localization chromatin organization, altered; transcription, induced; signaling pathway regulation 17105729; 21816276 3 4 0 SREBP pathway, regulates nuclear eccentricity -DNMT1 DNMT1 Amino Acid Metabolism - cysteine and methionine; Cell development/differentiation; EC 2.1.1.37; METHYLTRANSFERASE; Methyltransferase; Methyltransferase, DNA; Transcription regulation P26358 1786 19p13.2 human K366-ac 25171009 YLDDPDLkYGQHPPD cell cycle regulation 21947282 1 1 0 -HJURP HJURP Histone-binding; Nucleolus Q8NCD3 55355 2q37.1 human S473-p 483759 MYRGGPAsPGGLQGL molecular association, regulation; intracellular localization cell cycle regulation OIP5(DISRUPTS) 24519934 2 39 7 Mis18 binds with HJURP and specifies the centromere localization -MAPK8 JNK1 EC 2.7.11.24; KINASE; Kinase, protein; Protein kinase, CMGC; Protein kinase, Ser/Thr (non-receptor) P45983 5599 10q11.22 human Y185-p 447645 TSFMMTPyVVTRYYR Pkinase enzymatic activity, induced cell cycle regulation; carcinogenesis, induced; apoptosis, altered; carcinogenesis, inhibited; apoptosis, induced; cell motility, inhibited; transcription, induced; transcription, altered; signaling pathway regulation; cell differentiation, induced; cell growth, induced; cell adhesion, altered 10867021; 15944157; 17210579; 31575661; 33573023; 34034759; 34048499; 35790913; 35843311; 36289618; 37298039; 8137421; 9312068 270 48 1269 -PARP1 PARP1 DNA repair, damage; EC 2.4.2.30; Nuclear envelope; Nuclear receptor co-regulator; Nucleolus; Transferase P09874 142 1q42.12 human S786-p 21440501 RGGSDDSsKDPIDVN PARP_reg intracellular localization; enzymatic activity, inhibited 21922195 1 2 0 -HMGN2 HMGN2 DNA-binding P05204 3151 1p36.11 human S29-p 2574920 QRRSARLsAKPAPPK HMG14_17 intracellular localization 10739259 3 20 0 Phosphorylation facilitates localization to non-nuclear pools. -TFAM TFAM DNA-binding; Transcription regulation Q00059 7019 10q21.1 human S177-p 33402212 FQEAKGDsPQEKLKT HMG_box_2 molecular association, regulation transcription, inhibited DNA(DISRUPTS) 24768991 1 2 0 mitochondrial transcription; supression of mitochondrial biogenesis -Fzd3 FZD3 GPCR, Fz/Smo family; Membrane protein, integral; Membrane protein, multi-pass; Receptor, GPCR Q61086 14365 14 D1|14 34.09 cM mouse S588-p 18507006 KVSSYHGsLHRSRDG receptor internalization, inhibited; phosphorylation endocytosis, inhibited 21316586 1 4 0 enhances PCP signaling, regulating c-Jun phosphorylation, and affecting growth cone guidance -SULT2B1 SULT2B1 EC 2.8.2.2; Energy Metabolism - sulfur; Lipid Metabolism - androgen and estrogen; Transferase O00204 6820 19q13.33 human S348-p 21336503 REPRPNSsPSPSPGQ protein stabilization; molecular association, regulation; intracellular localization; protein conformation; enzymatic activity, induced SULT2B1(INDUCES) 21855633 1 1 1 -Kidins220 KIDINS220 Membrane protein, integral; Membrane protein, multi-pass; Protein kinase, regulatory subunit Q9EQG6 116478 6q16 rat Y1095-p 458291 PPRPPSGySQPASVC molecular association, regulation CRKL(INDUCES) 16284401 1 0 0 -Mpl MPL Membrane protein, integral; Receptor, cytokine Q08351 17480 4 D2.1|4 54.61 cM mouse Y582-p 454722 PSQPQMDyRGLQPCL activity, inhibited cell growth, altered 19996410 5 3 15 -SNU13 NHP2L1 Nucleolus; RNA splicing; RNA-binding; Spliceosome P55769 4809 22q13.2 human K33-m1 58123004 VQQSCNYkQLRKGAN Ribosomal_L7Ae molecular association, regulation L3MBTL iso4(INDUCES) 23583077 0 1 0 -STK24 MST3 EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, STE; Protein kinase, Ser/Thr (non-receptor) Q9Y6E0 8428 13q32.2 human T18-p 452058 ALNKRRAtLPHPGGS activity, induced 10644707 1 0 1 -STAT5B STAT5B DNA-binding; Oncoprotein; Transcription factor P51692 6777 17q21.2 human K701-ac 11323911 KAVDGYVkPQIKQVV phosphorylation transcription, induced 23980167 1 2 0 increases pSTAT5B at Y699 -PDE4D PDE4D iso6 EC 3.1.4.53; Nucleotide Metabolism - purine; Phosphodiesterase Q08499-6 5144 5q11.2-q12.1 human K323-sm 13310804 SIPRFGVkTEQEDVL enzymatic activity, induced 20196770 1 1 0 -AMER1 WTX iso2 Q5JTC6-2 139285 Xq11.2 human S286-p 23010401 SSLEEPHsPETGEKV WTX molecular association, regulation transcription, inhibited KEAP1(INDUCES) 22215675 1 5 0 WTX-KEAP1 interaction inhibits KEAP1-NRF2 interaction and NRF2 ubiquitination and degradation -PDGFRB PDGFRB EC 2.7.10.1; KINASE; Kinase, protein; Membrane protein, integral; Oncoprotein; Protein kinase, TK; Protein kinase, tyrosine (receptor) P09619 5159 5q32 human Y581-p 447519 SDGHEYIyVDPMQLP molecular association, regulation; phosphorylation; enzymatic activity, induced cell growth, altered RASA1(INDUCES); PLCG1(INDUCES); PIK3R1(INDUCES) 10642538; 10683371; 9454734; 9642269 6 1 0 -GFAP GFAP Cytoskeletal F1RR02 396562 pig S8-p 449618 MERRRVTsAARRSYV Filament_head neural plasticity; cell cycle regulation; cytoskeletal reorganization 1379174; 22528834 9 0 0 -Gab1 GAB1 Adaptor/scaffold; Motility/polarity/chemotaxis Q9QYY0 14388 8|8 C2 mouse Y373-p 447945 ASDTDSSyCIPPPAG molecular association, regulation cell differentiation, altered; cell growth, altered PLCG1(INDUCES) 10734310 6 15 279 -SALL4 SALL4 iso3 C2H2-type zinc finger protein; Cancer Testis Antigen (CTA); DNA-binding Q9UJQ4-2 57167 20q13.2 human K374-sm 31089511 SAVDVKPkDEAALYK protein stabilization; molecular association, regulation; intracellular localization transcription, induced Oct4(DISRUPTS) 23012367 1 0 0 -NPM1 NPM1 Nucleolus; Oncoprotein; RNA-binding; Translation P06748 4869 5q35.1 human T234-p 449024 SFKKQEKtPKTPKGP molecular association, regulation; intracellular localization cell cycle regulation; cell motility, induced; cell growth, induced; cytoskeletal reorganization ROCK2(INDUCES) RNA(DISRUPTS) 11278991; 12058066; 14670079; 26536659; 26993766; 30453269 7 21 17 stress fiber formation was enhanced, invasion and migration of HCC cells -POLB POLB DNA repair, damage; DNA replication; EC 2.7.7.7; Lyase; Transferase P06746 5423 8p11.21 human S55-p 41521701 KYPHKIKsGAEAKKL HHH_8 protein conformation; enzymatic activity, induced 30138833 3 0 0 -Cyp2b1 CYP2B6 Cofactor and Vitamin Metabolism - retinol; EC 1.14.14.1; Lipid Metabolism - arachidonic acid; Oxidoreductase; Xenobiotic Metabolism - drug metabolism - cytochrome P450; Xenobiotic Metabolism - metabolism by cytochrome P450 P00176 24300 1q21 rat S128-p 448738 WKALRRFsLATMRDF p450 enzymatic activity, inhibited; intracellular localization; protein conformation 10523294; 11745470; 12464263; 2583091 4 3 0 -CAPN2 CAPN2 EC 3.4.22.53; Motility/polarity/chemotaxis; Protease P17655 824 1q41 human S369-p 451303 DGNWRRGsTAGGCRN Calpain_III activity, inhibited cell motility, altered 11909964 2 1 2 -Casp8 CASP8 Apoptosis; EC 3.4.22.61; Protease O89110 12370 1 C1.3|1 29.19 cM mouse T265-p 21258500 KMKDRKGtDCDKEAL Peptidase_C14 enzymatic activity, inhibited; protein conformation; phosphorylation 32979304 2 1 0 induces RIP3/MLKL phosphorylation -CTPS1 CTPS EC 6.3.4.2; Ligase; Motility/polarity/chemotaxis; Nucleotide Metabolism - pyrimidine P17812 1503 1p34.2 human S571-p 457565 RDTYSDRsGSSSPDS activity, inhibited 17681942 1 35 3 -CD151 CD151 Membrane protein, integral; Membrane protein, multi-pass P48509 977 11p15.5 human K7-ub 4666605 _MGEFNEkKTTCGTV protein degradation 18713730 1 0 0 cell surface downregulation of tetraspanins -TP53BP1 53BP1 DNA repair, damage; Transcription, coactivator/corepressor Q12888 7158 15q15.3 human S1618-p 3194894 LTKAADIsLDNLVEG activity, induced; molecular association, regulation; ubiquitination; intracellular localization cell cycle regulation; chromatin organization, altered; DNA repair, inhibited RNF168(DISRUPTS) 24703952; 25607646 2 30 0 induce genome stability and Abrogates 53BP1 Foci in G1 Cells. Prevents the interaction of 53BP1 with chromatin.; localization at kinetochores -FOXO1 FOXO1A DNA-binding; Nuclear receptor co-regulator; Oncoprotein; Transcription factor Q12778 2308 13q14.11 human S298-p 471972 QFSKWPAsPGSHSND intracellular localization cell growth, induced; transcription, inhibited; transcription, altered 20061393; 23995784 6 12 30 -Septin7 SEPT7 Cell cycle regulation; Cytoskeletal; Hydrolase O55131 235072 9|9 A4 mouse T425-p 476328 EQQNSSRtLEKNKKK molecular association, regulation; intracellular localization cytoskeletal reorganization PSD-95(INDUCES) 28065648 2 56 46 required for dendritic spine formation, localizes to dendritic spines on phosphorylation -Rps6ka1 p90RSK EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, AGC; Protein kinase, Ser/Thr (non-receptor); Translation Q63531 81771 5q36 rat S221-p 447988 DHEKKAYsFCGTVEY Pkinase molecular association, regulation; intracellular localization; enzymatic activity, inhibited; phosphorylation; enzymatic activity, induced cell growth, induced; apoptosis, inhibited; translation, induced PKAR1A(DISRUPTS); PKAR1A(INDUCES) 20048145; 22130794; 35648763 10 42 95 induces eEF2K phosphorylation -Sod2 SOD2 EC 1.15.1.1; Mitochondrial; Oxidoreductase P09671 20656 17 A1|17 8.75 cM mouse K75-ac 33350042 KYHEALAkGDVTTQV Sod_Fe_N enzymatic activity, altered 28433661 0 3 0 -Cacna1b CACNA1B iso2 Channel, calcium; Membrane protein, integral; Membrane protein, multi-pass Q6XS92 257648 3p13 rat Y52-p 14080100 RIHYKDMySLLRCIA GPHH activity, inhibited 17293861 1 0 0 voltage-dependent inhibition of channel currents -USP25 USP25 DEUBIQUITINASE; EC 3.4.19.12; Protease; Ubiquitin conjugating system; Ubiquitin-specific protease Q9UHP3 29761 21q21.1 human K99-ub 7761222 IDLTGDDkDDLQRAI UIM enzymatic activity, induced 19440361 1 3 1 -Rps6 S6 Translation P62754 20104 4|4 C4 mouse S244-p 448095 LRASTSKsESSQK__ activity, induced neural plasticity; carcinogenesis, induced; carcinogenesis, inhibited; transcription, induced; transcription, altered 23361300; 26590421; 33826903; 34344824; 34819370 108 34 561 -DGKK DGKK EC 2.7.1.107; Kinase, lipid Q5KSL6 139189 Xp11.22 human Y78-p 457633 SESATELyTEPTPEP enzymatic activity, inhibited 16210324 1 0 0 -TFEB TFEB DNA-binding; Transcription factor P19484 7942 6p21.1 human S134-p 31886898 AGHVLSSsAGNSAPN MITF_TFEB_C_3_N intracellular localization 33753903 1 2 0 -MAPT Tau iso8 ACETYLTRANSFERASE; Acetyltransferase; Cytoskeletal P10636-8 4137 17q21.31 human K280-ac 25223700 GKVQIINkKLDLSNV Tubulin-binding molecular association, regulation; protein conformation; phosphorylation cytoskeletal reorganization 21427723; 28855586; 31543505; 33496017; 34966788 13 2 0 alters the H-bond is associations and strengthens the residue-residue interactions; K280 acetylation promotes formation of the beta-sheet PHF6* peptides and the formation of larger beta-sheet oligomers; could impair tau interactions with microtubules; inhibts Tau iso8 phosphorylation and microtubule binding, ameliorates amyloid-beta toxicity; induces PHF6* peptides to become more compact; K280Q mutant aggregates faster and forms longer fibrils than K18, forms seeds more slowly, binds to fibrils with marginally lower affinity, the fibrils of K289Q converts monomeric protein into fibrils slower, but monomeric tau-K18 K280Q converts into fibrils faster ; K280Q mutant caused a reduction of S202/T205 phosphorylation, reduced neuroinflammation, restored levels of N-methyl- D-aspartate receptors and post-synaptic markers compared with the parental mice, altered conformation, reduced astrogliosis and microgliosis, restored synaptic homeostasis -MAVS MAVS Adaptor/scaffold; Membrane protein, integral Q7Z434 57506 20p13 human T234-p 3204129 FQPLARStPRASRLP molecular association, regulation PLK1(INDUCES) 19546225 1 4 2 -BAP1 BAP1 DEUBIQUITINASE; EC 3.4.19.12; Protease; Tumor suppressor; Ubiquitin conjugating system; Ubiquitin-specific protease Q92560 8314 3p21.1 human T493-p 37043703 PTPSNEStDTASEIG molecular association, regulation; intracellular localization FOXK2(INDUCES); FOXK1(INDUCES) 25451922 1 0 0 -EP300 p300 ACETYLTRANSFERASE; Acetyltransferase; EC 2.3.1.48; Motility/polarity/chemotaxis; Nuclear receptor co-regulator; Transcription, coactivator/corepressor Q09472 2033 22q13.2 human S1834-p 447591 MLRRRMAsMQRTGVV molecular association, regulation transcription, induced CAF-1A(INDUCES) 16024795; 16926151 9 0 0 vorinostat recruitment of acetyl-p65 K310, phospho-p300 (Ser1834), phospho-Akt (Ser473), and RNA polymerase II formation on both cIAP2 and Bfl-1/A1 promoters -Ahr AHR DNA-binding; Transcription factor P30561 11622 12 A3|12 15.78 cM mouse S35-p 451413 EGIKSNPsKRHRDRL HLH carcinogenesis, induced; apoptosis, inhibited 35405096 2 1 0 -Slc12a1 NKCC2 Membrane protein, integral; Membrane protein, multi-pass; Transporter; Transporter, SLC family P55016 25065 3q36 rat S126-p 478420 GPKVNRPsLQEIHEQ AA_permease_N activity, induced; molecular association, regulation ANXA2(DISRUPTS) 24526686 8 2 0 Low chloride hypotonic stress enhances raft association of NKCC2 and AnxA2 -SLC9A5 NHE5 Membrane protein, integral; Membrane protein, multi-pass; Transporter; Transporter, SLC family Q14940 6553 16q22.1 human S709-p 20832304 SEEEEEEsDSSETEK molecular association, regulation; activity, inhibited endocytosis, induced ARRB1(INDUCES) 21296876 1 0 0 -Pdx1 PDX1 DNA-binding; Transcription factor P52946 18609 5 G3|5 86.84 cM mouse T231-p 13421407 PEQDCAVtSGEELLA transcription, inhibited 20339896 1 0 0 -DLG4 PSD-95 Adaptor/scaffold P78352 1742 17p13.1 human S561-p 25680400 EFPDKFGsCVPHTTR Guanylate_kin neural plasticity; cytoskeletal reorganization 22807451 2 1 0 dendritic spine morphogenesis -Tp53 p53 Activator; DNA-binding; Motility/polarity/chemotaxis; Nuclear receptor co-regulator; Transcription factor; Tumor suppressor P02340 22059 11 B3|11 42.83 cM mouse K378-ub 464657 GQSTSRHkKTMVKKV transcription, altered 15964796 10 0 0 p53K6R (K378/383/369/379/367/370/R) mutant is still ubiquitinated and shows normal stability of p53 before and after DNA damage -Atoh1 ATOH1 Cell development/differentiation; DNA-binding; Transcription factor P48985 11921 6 C1|6 30.03 cM mouse S309-p 57761909 MMAQKDLsPSLPGGI protein stabilization; ubiquitination; phosphorylation cell differentiation, inhibited; cell cycle regulation; cell growth, induced 34057742 2 2 0 inhibits phosphorylation at S328 and ubiquitinatiion -MEF2A MEF2A DNA-binding; Motility/polarity/chemotaxis; Transcription factor Q02078 4205 15q26.3 human S355-p 449934 SALQGFNsPGMLSLG activity, induced 10849446 1 0 0 -Enpp1 ENPP1 Carbohydrate Metabolism - starch and sucrose; Cofactor and Vitamin Metabolism - nicotinate and nicotinamide; Cofactor and Vitamin Metabolism - pantothenate and CoA biosynthesis; Cofactor and Vitamin Metabolism - riboflavin; EC 3.1.4.1; EC 3.6.1.9; KINASE; Membrane protein, integral; Motility/polarity/chemotaxis; Nucleotide Metabolism - purine; Phosphatase (non-protein); Phosphodiesterase Q924C3 85496 1p12 rat T238-p 451402 RPVYPTKtFPNHYSI Phosphodiest enzymatic activity, inhibited 8917428 1 7 1 -NAA50 NAA50 ACETYLTRANSFERASE; Acetyltransferase; EC 2.3.1.- Q9GZZ1 80218 3q13.31 human K34-ac 461831 FPVSYNDkFYKDVLE Acetyltransf_1 acetylation; enzymatic activity, induced 19744929 1 7 98 reduces histone acetylation and increases NAT activity, thereby increasing enzyme specificity -Tmbim1 TMBIM1 Membrane protein, integral; Membrane protein, multi-pass Q8BJZ3 69660 1|1 C3 mouse K126-ub 1873041104 TFVEPVGkYVRNNVA Bax1-I molecular association, regulation Hrs(INDUCES) 28481357 1 1 0 -HDAC2 HDAC2 DEACETYLASE; Deacetylase; EC 3.5.1.98; Nuclear receptor co-regulator; Transcription, coactivator/corepressor Q92769 3066 6q21 human S394-p 449930 EDAVHEDsGDEDGED acetylation; molecular association, regulation; enzymatic activity, inhibited; enzymatic activity, induced apoptosis, induced p53(INDUCES); HDAC1(INDUCES); FOXO3A(INDUCES); SIN3A(INDUCES); CHD-3 iso3(INDUCES) 12082111; 20388487; 25609639 6 87 52 -MEF2C MEF2C iso3 DNA-binding; Transcription factor Q06413-3 4208 5q14.3 human T300-p 448001 TPVVSVAtPTLPGQG activity, induced transcription, altered 9069290 2 0 0 -E6 HPV16 protein E6 P03126 1489078 papillomavirus T156-p 1884110701 SSRTRREtQL_____ molecular association, regulation 14-3-3 sigma(INDUCES); 14-3-3 zeta(INDUCES); 14-3-3 gamma(INDUCES) 36775199 1 0 0 -CDT1 CDT1 DNA replication; DNA-binding; Motility/polarity/chemotaxis; Oncoprotein Q9H211 81620 16q24.3 human T102-p 31889833 GQKIKKStPAAGQPP cell cycle regulation; cytoskeletal reorganization 30154187 1 1 0 regulates kTM stability -ATXN7 ataxin-7 Nucleolus; Transcription regulation O15265 6314 3p14.1 human K257-ac 11489911 RIMTPSVkVEKIHPK protein stabilization; molecular association, regulation; intracellular localization 19955365 1 0 0 regulates stability (accumulation) of ataxin-7 N-terminal cleavage fragment, colocalizes with LAMP2 a lysosomal marker, which is important in autophagy -Fadd FADD Adaptor/scaffold; Apoptosis Q61160 14082 7 F5|7 88.85 cM mouse S191-p 447653 VSKSENMsPVLRDST intracellular localization cell cycle regulation; cell growth, inhibited; apoptosis, induced; cell growth, altered 12705854; 16061179; 17553783; 18657552; 35753028 15 28 0 -Nfkbib IkB-beta Inhibitor Q60778 18036 7|7 B1 mouse S19-p 447917 DADEWCDsGLGSLGP protein degradation 10497169; 9092533 6 0 0 -MAD2L1 MAD2L1 Cell cycle regulation Q13257 4085 4q27 human S178-p 11280300 GPQFITNsEEVRLRS HORMA molecular association, regulation cell cycle regulation Mad1(DISRUPTS) 12574116 2 0 0 -Kcnj11 Kir6.2 Channel, potassium; Membrane protein, integral; Membrane protein, multi-pass P70673 rat S385-p 2103601 AKPKFSIsPDSLS__ exocytosis, altered 19357830 2 3 0 regulates insulin secretion -MDH2 MDH2 Carbohydrate Metabolism - citrate (TCA) cycle; Carbohydrate Metabolism - glyoxylate and dicarboxylate; Carbohydrate Metabolism - pyruvate; EC 1.1.1.37; Mitochondrial; Oxidoreductase P40926 4191 7q11.23 human K314-ac 466434 KVSSFEEkMISDAIP Ldh_1_C enzymatic activity, induced 20167786 0 10 8 -CBL CBL Adaptor/scaffold; EC 6.3.2.-; EC 6.3.2.19; Ligase; Motility/polarity/chemotaxis; Oncoprotein; UBIQUITIN LIGASE; Ubiquitin conjugating system; Ubiquitin ligase P22681 867 11q23.3 human Y371-p 449753 TQEQYELyCEMGSTF protein degradation; molecular association, regulation; protein conformation; phosphorylation; enzymatic activity, induced cell cycle regulation; apoptosis, altered; carcinogenesis, inhibited; apoptosis, induced; signaling pathway regulation; cell growth, altered EGFR(INDUCES); SH3KBP1(DISRUPTS); EGFR(DISRUPTS); CRK(INDUCES); PIK3R1(INDUCES) 10635327; 11448952; 11997497; 15117950; 20622007; 24469048; 33627783 8 10 81 inhibits phosphorylation at other sites, regulates RTK signaling -GFPT1 GFAT Amino Acid Metabolism - alanine, aspartate and glutamate; Carbohydrate Metabolism - amino sugar and nucleotide sugar; EC 2.6.1.16; Transferase Q06210 2673 2p13.3 human S261-p 467935 CNLSRVDsTTCLFPV enzymatic activity, induced 17941647 4 83 522 -MALT1 MALT1 Adaptor/scaffold; Apoptosis; EC 3.4.22.-; Ligase; Nuclear export; Protease; UBIQUITIN LIGASE; Ubiquitin conjugating system Q9UDY8 10892 18q21.32 human K679-ub 2134700 LSSLQKLkEHLVFTV MALT1_Ig protein degradation; molecular association, regulation IKKA(INDUCES) 17948050 1 0 0 activation of NF-kB pathway and IL-2 induction -AQP5 AQP5 Channel, misc.; Membrane protein, integral; Membrane protein, multi-pass; Transporter; Transporter, aquaporin family P55064 362 12q13.12 human S183-p 1868832800 GIYFTGCsMNPARSF MIP activity, inhibited 31277235 1 0 0 impaired water permeability through pore blockage -DCX Doublecortin Cytoskeletal; Motility/polarity/chemotaxis O43602 1641 Xq23 human S28-p 451358 SRMNGLPsPTHSAHC molecular association, regulation cell motility, induced; cell motility, altered; cytoskeletal reorganization TUBA1A(DISRUPTS); ACTB(INDUCES); Spinophilin(INDUCES) 30625347 2 1 2 -DCBLD2 DCBLD2 Cell adhesion; Membrane protein, integral Q96PD2 131566 3q12.1|3 human Y655-p 478857 GYADLDPyNSPGQEV molecular association, regulation CRKL(INDUCES) 23770091 2 4 7 -FBXW7 FBXW7 Motility/polarity/chemotaxis; Nucleolus; UBIQUITIN LIGASE; Ubiquitin conjugating system; Ubiquitin ligase Q969H0 55294 4q31.3 human S18-p 17337001 KRRRTGGsLRGNPSS molecular association, regulation; ubiquitination; protein conformation CCNE1(DISRUPTS) 28850619 2 0 0 it is inactive towards its substrate cyclin E, negatively regulates cyclin E binding by interfering with Fbw7a dimerization -FUS hnRNP P2 DNA-binding; Nuclear receptor co-regulator; Oncoprotein; RNA splicing; RNA-binding; SUMO LIGASE P35637 2521 16p11.2 human S221-p 12217071 GGRGRGGsGGGGGGG molecular association, regulation hnRNP P2(DISRUPTS) 35753345 1 5 4 -GLI3 GLI3 C2H2-type zinc finger protein; Transcription factor P10071 2737 7p14.1 human S865-p 15501379 YLSSRRSsGISPCFS protein processing transcription, inhibited 10693759 1 2 6 -HRAS HRas G protein; G protein, monomeric; G protein, monomeric, Ras; Motility/polarity/chemotaxis; Oncoprotein P01112 3265 11p15.5 human T144-p 25324400 YGIPYIEtSAKTRQG Ras protein degradation; molecular association, regulation; ubiquitination; phosphorylation carcinogenesis, inhibited; cell growth, inhibited; transcription, inhibited; signaling pathway regulation CTNNB1(DISRUPTS); BTRC(INDUCES) 22494971; 30413483 2 1 0 ERK phosphorylation, ERK pathway activation -Myod1 MyoD DNA-binding; RNA splicing; Transcription factor P10085 17927 7 B3|7 30.03 cM mouse K102-ac 458969 LWACKACkRKTTNAD Basic activity, induced transcription, induced 10944526 3 1 1 -UHRF1 UHRF1 DNA-binding; EC 6.3.2.-; EC 6.3.2.19; Ligase; Transcription factor; UBIQUITIN LIGASE; Ubiquitin conjugating system; Ubiquitin ligase Q96T88 29128 19p13.3 human K646-ac 1883407604 SPRTGKGkWKRKSAG cell cycle regulation; cell growth, induced 35951156 1 0 0 -TFB2M TFB2M EC 2.1.1.-; METHYLTRANSFERASE; Methyltransferase; Transcription, coactivator/corepressor Q9H5Q4 64216 1q44 human T313-p 55379187 NLFTKNLtPMNYNIF RrnaAD molecular association, regulation; protein conformation transcription, inhibited POLRMT(DISRUPTS) DNA(DISRUPTS) 32505352 1 1 0 -PPP2R5C PPP2R5C Motility/polarity/chemotaxis; PHOSPHATASE; Protein phosphatase, regulatory subunit Q13362 5527 14q32.31 human S520-p 18958501 CRADELAsQDGR___ protein stabilization; molecular association, regulation; ubiquitination; phosphorylation cell cycle regulation; carcinogenesis, inhibited; cell growth, inhibited; transcription, induced MDM2(DISRUPTS); p53(INDUCES) 21460856 1 0 12 induces dephosphorylation of p53 -LTB4R LTB4R GPCR, family 1; Membrane protein, integral; Membrane protein, multi-pass; Receptor, GPCR Q15722 1241 14q12 human S314-p 25299233 GTGSEASsTRRGGSL receptor internalization, induced; phosphorylation signaling pathway regulation 22707565; 30131369 2 2 1 phosphorylation of LTB4R basal phosphorylation site; enhanced ligand-induced internalization ; chemotaxis, B-hexisaminidase release, regulates LTB4R function -CD300LF IREM-1 Immunoglobulin superfamily; Membrane protein, integral; Receptor, misc. Q8TDQ1 146722 17q25.1 human Y205-p 474545 PLEGDLCyADLTLQL SIT activity, induced; molecular association, regulation; enzymatic activity, induced SHP-1(INDUCES) 15549731; 17202342; 32152116 4 0 0 activation of PLC gamma which leads to the activation of PKC; mutation of site to Phe decreased the inhibitory activity of IREM-1 -DMTN dematin Actin-binding; Motility/polarity/chemotaxis; Tumor suppressor Q08495 2039 8p21.3 human S92-p 456372 SLSPKSTsPPPSPEV AbLIM_anchor protein conformation 19030997 1 23 1 facilitating actin bundling activity -Sp7 osterix C2H2-type zinc finger protein; DNA-binding; Transcription factor Q8VI67 170574 15|15 F3 mouse S73-p 15334100 SSTNGLLsPAGSPPA activity, induced; protein degradation; molecular association, regulation; ubiquitination cell differentiation, inhibited; transcription, altered FBXW7(INDUCES); p300(INDUCES); SMARCA4(INDUCES) 20682789; 32931083 4 0 0 -Ptpn5 STEP EC 3.1.3.48; Membrane protein, multi-pass; Motility/polarity/chemotaxis; PHOSPHATASE; Protein phosphatase, tyrosine (non-receptor) P54830 19259 7 B3|7 30.7 cM mouse S221-p 448294 GLQERRGsNVSLTLD molecular association, regulation; enzymatic activity, inhibited; phosphorylation ERK1(DISRUPTS); ERK2(DISRUPTS) 25583483; 25689923 9 0 0 -SIK2 QIK EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, CAMK; Protein kinase, Ser/Thr (non-receptor) Q9H0K1 23235 11q23.1 human T484-p 478056 RSGQRRHtLSEVTNQ protein stabilization 30586628 3 10 85 -Tnfrsf1a TNF-R1 Membrane protein, integral; Receptor, cytokine P25118 21937 6 F3|6 59.32 cM mouse K256-ub 52440800 CRDPVPVkEEKAGKP ubiquitination 26649818 1 1 0 -NFE2L2 NRF2 DNA-binding; Transcription factor Q16236 4780 2q31.2 human K462-ac 7106318 TRDELRAkALHIPFP molecular association, regulation transcription, induced DNA(INDUCES) 19273602 1 1 0 -PPP2CA PPP2CA EC 3.1.3.16; Motility/polarity/chemotaxis; PHOSPHATASE; Protein phosphatase, Ser/Thr (non-receptor) P67775 5515 5q31.1 human Y284-p 457325 ELDDTLKySFLQFDP protein conformation; phosphorylation 35820485 1 2 17 -Stk38 NDR1 EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, AGC; Protein kinase, Ser/Thr (non-receptor) Q91VJ4 106504 17|17 A3.3 mouse T444-p 460659 DWVFINYtYKRFEGL Pkinase_C enzymatic activity, induced apoptosis, induced; signaling pathway regulation 21730291 7 2 1 MST-NDR pathway -ITGB4 ITGB4 iso2 Cell adhesion; Membrane protein, integral; Motility/polarity/chemotaxis; Receptor, misc. P16144-2 3691 17q25.1 human T1736-p 1243302 EFVSRTLtTSGTLST molecular association, regulation; intracellular localization; protein conformation Plectin-1(DISRUPTS); ITGB4 iso2(INDUCES) 22357621 2 1 4 regulates HD assembly -ETV1 ETV1 DNA-binding; Oncoprotein; Transcription factor P50549 2115 7p21.2 human K116-ac 458951 FKFSYGEkCLYNVSA ETS_PEA3_N protein stabilization; molecular association, regulation transcription, induced DNA(INDUCES) 12917345 1 1 0 -CREB1 CREB DNA-binding; Transcription factor P16220 1385 2q33.3 human S115-p 450092 QKRREILsRRPSYRK pKID molecular association, regulation cell growth, induced; transcription, induced MEIS1(INDUCES) 20541704 10 0 2 -Kcnd2 Kv4.2 Channel, potassium; Membrane protein, integral; Membrane protein, multi-pass Q9Z0V2 16508 6 A2-A3.1|6 8.49 cM mouse T607-p 457612 IPTPPVTtPEGDDRP activity, induced neural plasticity 16251476; 32824677 7 0 0 the T607D mutant effects required KChIP3 coexpression. Mutation with 3 residues mutated to D decreased the transient outward K+ current and showed higher activation voltage. ; regulates neuronal excitability and behavioral seizure strength -H2BC3 H2B DNA-binding P33778 3018 6p22.2 human K125-ub 12093729 VTKYTSSk_______ molecular association, regulation; intracellular localization DNA repair, induced 21362549 2 2 1 RNF20-RNF40 is required for retention of XRCC4 at DSB sites -MECP2 MECP2 Transcription, coactivator/corepressor P51608 4204 Xq28 human S229-p 1727702 VKMPFQTsPGGKAEG molecular association, regulation transcription, induced; transcription, altered YB-1(INDUCES); SIN3A(INDUCES); HP1 alpha(INDUCES); SMC3(INDUCES) 22615490 3 28 0 Induces RET expression; Phosphorylation of S80 and S229 leads to activation and repression of EGR2 expression. Phosphorylated S80 interacts with YB-1 in RNA dependent manner -AKAP12 AKAP12 Adaptor/scaffold Q02952 9590 6q25.1 human S732-p 481957 TDGILAGsQEHDPGQ molecular association, regulation; intracellular localization DNA repair, induced DNA(INDUCES) 27683220 1 4 0 -Pdcl PhLP G protein regulator, misc. Q63737 64013 3q11 rat S18-p 448823 EKLQYYYsTSEDEDS activity, inhibited 12466282 4 4 2 -HTT Huntingtin Cytoskeletal P42858 3064 4p16.3 human K6-ub 1877148902 __MATLEkLMKAFES ubiquitination 32675242 1 0 0 K6 and K9 sites were ubquitinated in WT were mutated to R and slowed aggregation and reduce size, but increase in smaller size aggregates but increased death rates. -Ripk2 RIPK2 EC 2.7.10.2; EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, Ser/Thr (non-receptor); Protein kinase, TKL; Protein kinase, tyrosine (non-receptor) P58801 192656 4 A2|4 6.7 cM mouse K209-ub 2793000 QKSRASVkHDIYSYA PK_Tyr_Ser-Thr phosphorylation; enzymatic activity, induced signaling pathway regulation 23109427 3 1 0 regulation NOD2 signaling -Snai2 Snail2 Apoptosis; C2H2-type zinc finger protein; Motility/polarity/chemotaxis; Transcription factor P97469 20583 16 A1|16 10.07 cM mouse S4-p 25525401 ____MPRsFLVKKHF transcription, inhibited 22567133 1 0 0 regulates epithelial to mesenchymal transition (EMT) -Slc12a3 NCCT Membrane protein, integral; Membrane protein, multi-pass; Transporter; Transporter, SLC family P59158 20497 8 C5|8 46.46 cM mouse T48-p 4709842 SHLTHGStLYMRTFG AA_permease_N activity, induced; phosphorylation 22342722 4 1 0 increases NCCT protein abundance and its phosphorylation by activated OSR1 -ACLY ACLY Carbohydrate Metabolism - citrate (TCA) cycle; EC 2.3.3.8; Lyase; Transferase P53396 47 17q21.2 human T447-p 455371 NASGSTStPAPSRTA signaling pathway regulation 26039450 2 3 62 IGF1/AKT/ACL/cardiolipin/ATP pathway -PAK3 PAK3 EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, STE; Protein kinase, Ser/Thr (non-receptor) O75914 5063 Xq23 human T436-p 448126 PEQSKRStMVGTPYW Pkinase cytoskeletal reorganization 17077177 3 2 11 Mutation of any of the 4 serines/threonines to alanine reduced the AILIM/ICOS-induced elongation ratio in activated T cells. Three sites are believed to be autophosphorylation sites, and one is believed to be an Akt1 site. Treatment with Akt inhibitor shows a reduction in this elongation ratio. -Arhgap42 ARHGAP42 GAP; GAP, Rac/Rho B2RQE8 71544 9|9 A1 mouse Y342-p 450878 MDGKEPIyTLPAIIS cell cycle regulation; cell motility, altered 18515860 1 19 227 -TCEAL1 SIIR iso2 Transcription initiation complex AAA60149 9338 Xq22.2 human S37-p 451218 KSSPPRSsLRRSSPR BEX transcription, altered 7592688 1 0 0 S36A/S37A mutation resulted in a substantial loss of LTR repression function suggesting that RSV LTR repression may be regulated by S36 and/or S37 phosphorylation. -Mapt Tau ACETYLTRANSFERASE; Acetyltransferase; Cytoskeletal P19332 29477 10q32.1 rat S546-p 449080 VVRTPPKsPSASKSR cytoskeletal reorganization 18245083 45 36 25 -Igf1r IGF1R EC 2.7.10.1; KINASE; Kinase, protein; Membrane protein, integral; Protein kinase, TK; Protein kinase, tyrosine (receptor) Q60751 16001 7 C|7 37.27 cM mouse Y1167-p 448387 RDIYETDyYRKGGKG PK_Tyr_Ser-Thr intracellular localization; enzymatic activity, induced cell cycle regulation; cell growth, induced; cell differentiation, induced; cell motility, altered 18515860; 23954591; 35320720; 8940173 20 38 707 -FOXP3 FOXP3 C2H2-type zinc finger protein; Cell cycle regulation; DNA-binding; Transcription factor Q9BZS1 50943 Xp11.23 human K268-ac 25614401 AGKMALTkASSVASS protein stabilization 23644046 3 1 0 -TFCP2L1 TFCP2L1 DNA-binding Q9NZI6 29842 2q14.2 human K30-sm 25352008 VLALPIFkQEEPQLS CP2 transcription, inhibited 20661472 1 1 0 -IL9R IL9R Membrane protein, integral; Receptor, cytokine Q01113 3581 Xq28 and Yq12 human S518-p 450656 SVLSKARsWTF____ molecular association, regulation 14-3-3 zeta(INDUCES) 10642536 1 0 0 -Pdcl PhLP G protein regulator, misc. Q63737 64013 3q11 rat T19-p 448824 KLQYYYStSEDEDSD activity, inhibited 12466282 4 3 3 -IKBKG IKKG Adaptor/scaffold; Protein kinase, regulatory subunit Q9Y6K9 8517 Xq28 human K321-ub 7482000 AERQAREkLAEKKEL CC2-LZ signaling pathway regulation 17728323 2 1 0 -PSMC4 RPT3 Nuclear receptor co-regulator; Protease; Proteasome complex P43686 5704 19q13.2 human T25-p 3190483 LSVSRPQtGLSFLGP activity, induced; enzymatic activity, induced cell cycle regulation; carcinogenesis, induced; carcinogenesis, inhibited; cell growth, induced 26655835; 31754034 3 4 7 regulates proteasome function; peptidase activity of 26S proteosome inhibited; required for efficient proteasomal degradation -PTEN PTEN Carbohydrate Metabolism - inositol phosphate; EC 3.1.3.16; EC 3.1.3.48; EC 3.1.3.67; Motility/polarity/chemotaxis; Nuclear receptor co-regulator; PHOSPHATASE; Phosphatase, lipid; Tumor suppressor P60484 5728 10q23.31 human K266-sm 27490409 HKQNKMLkKDKMFHF PTEN_C2 protein stabilization; molecular association, regulation; ubiquitination; intracellular localization cell cycle regulation; carcinogenesis, inhibited; apoptosis, induced; cell growth, inhibited ubiquitin(DISRUPTS) 23013792; 24344134; 27506944; 27852060 4 0 0 -Sh2b1 SH2-B-beta Adaptor/scaffold Q62985 89817 1q36 rat Y439-p 448753 DRLSQGAyGGLSDRP cell motility, induced; cytoskeletal reorganization 12551917; 23444381 2 1 1 membrane ruffling; macrophage migration -FOXO3 FOXO3A Autophagy; DNA-binding; Oncoprotein; Transcription factor O43524 2309 6q21 human S399-p 20799902 DNITLPPsQPSPTGG phosphorylation transcription, induced 17711846 2 1 0 induces phosphorylation of other sites -AVPR2 AVPR2 GPCR, family 1; Membrane protein, integral; Membrane protein, multi-pass; Receptor, GPCR; Transporter; Transporter, aquaporin family P30518 554 Xq28 human S364-p 451069 SCTTASSsLAKDTSS intracellular localization 9482866 1 0 0 After receptor activation, phosphorylation of serines 362, 363, and 364 inhibits overall dephosphorylation of the internalized receptor, thereby inhibiting recycling of the receptor to the cell surface. -DPYSL2 CRMP-2 Microtubule-binding; Motility/polarity/chemotaxis Q16555 1808 8p21.2 human T509-p 448083 PVCEVSVtPKTVTPA molecular association, regulation; intracellular localization apoptosis, induced DRP1(DISRUPTS); RHOT2(DISRUPTS); MFN2(DISRUPTS) 34831395; 37174687 16 63 34 -Rps6ka1 p90RSK EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, AGC; Protein kinase, Ser/Thr (non-receptor); Translation P18653 20111 4|4 D2.3 mouse T348-p 447992 DTEFTSRtPRDSPGI Pkinase_C enzymatic activity, induced 14726002 41 28 2 -RPS10 RPS10 Nucleolus; RNA-binding; Ribosomal; Translation P46783 6204 6p21.31 human R158-me 13906404 QFRGGFGrGRGQPPQ protein stabilization; molecular association, regulation; intracellular localization NPM1(INDUCES) 20159986 1 0 0 localization in the granular component (GC) region of the nucleolus; efficient assembly of RPS10 into ribosomes and protein synthesis -VIM Vimentin Cytoskeletal; Motility/polarity/chemotaxis P08670 7431 10p13 human S72-p 449026 SSAVRLRsSVPGVRL Filament_head activity, induced carcinogenesis, induced; cell motility, induced; cytoskeletal reorganization; cell motility, inhibited 23737341; 25908861; 28117759; 31931758 21 34 40 -Pdha1 PDHA1 Amino Acid Metabolism - valine, leucine and isoleucine biosynthesis; Carbohydrate Metabolism - butanoate; Carbohydrate Metabolism - citrate (TCA) cycle; Carbohydrate Metabolism - glycolysis and gluconeogenesis; Carbohydrate Metabolism - pyruvate; EC 1.2.4.1; Mitochondrial; Oxidoreductase P35486 18597 X F4|X 73.95 cM mouse S300-p 448259 SMSDPGVsYRTREEI E1_dh enzymatic activity, inhibited 31435015; 32079675; 33826891; 36211560 53 76 476 -TOP2A TOP2A EC 5.99.1.3; Isomerase P11388 7153 17q21.2 human K1240-sm 15511902 KKNKKKIkNENTEGS intracellular localization 30871006 1 5 0 influences mitotic localization of TOP2A -Myc Myc DNA-binding; Nucleolus; Oncoprotein; Transcription factor P01108 17869 15 D1|15 26.19 cM mouse S77-p 448586 LLPTPPLsPSRRSGL Myc_N protein degradation; protein stabilization; molecular association, regulation; phosphorylation cell cycle regulation; carcinogenesis, induced; carcinogenesis, inhibited; cell growth, inhibited; signaling pathway regulation; transcription, altered; cell growth, induced; apoptosis, inhibited PIN1(INDUCES) 15048125; 34088288; 35380701; 36581205; 36765089 86 38 33 -VCPIP1 VCIP135 Cell cycle regulation; DEUBIQUITINASE; EC 3.4.19.12; Protease; Ubiquitin conjugating system; Ubiquitin-specific protease Q96JH7 80124 8q13.1 human S768-p 3149749 TPTKAPYsPTTSKEK molecular association, regulation cell cycle regulation VCP(DISRUPTS) 23500464 1 20 7 Golgi disassembly at mitosis, inhibits membrane fusion -H3C1 H3 DNA-binding P68431 8350 6p22.2 human R8-m2 4279300 ARTKQTArKSTGGKA Histone molecular association, regulation; enzymatic activity, inhibited 19187761 6 1 0 MLL1 reduced methyltransferase activity and binding affinity with substrate with R8-M2 modification as compared to substrate with no modification -SUGT1 SUGT1 Cell cycle regulation; Ubiquitin conjugating system Q9Y2Z0 10910 13q14.3 human S17-p 140698200 TSQRFFQsFSDALID protein stabilization; molecular association, regulation cell cycle regulation RNF41(INDUCES) 28696259 1 1 0 -Eif3f eIF3-epsilon EC 3.4.19.12; Translation; Translation initiation Q9DCH4 66085 7|7 E3 mouse K242-ub 7388003 MFTPLTVkYAYYDTE protein degradation 19073596 1 4 9 regulates skeletal muscle atrophy -TBXA2R TXA2-R GPCR, family 1; Membrane protein, integral; Membrane protein, multi-pass; Receptor, GPCR P21731 6915 19p13.3 human S329-p 450989 RLSTRPRsLSLQPQL receptor desensitization, altered 10827090 3 8 2 TXA2-R alpha is subject to cross-desensitization by the prostacyclin receptor which is mediated through direct PKA phosphorylation of S329. -Lats1 LATS1 EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, AGC; Protein kinase, Ser/Thr (non-receptor); Tumor suppressor Q8BYR2 16798 10|10 A1 mouse T1078-p 457595 EHAFYEFtFRRFFDD carcinogenesis, inhibited; cell growth, inhibited; apoptosis, induced; cell motility, inhibited; transcription, inhibited 35697803 34 1 0 -ATRIP ATRIP Cell cycle regulation; DNA repair, damage; DNA-binding Q8WXE1 84126 3p21.31 human S239-p 485777 VIKPEACsPQFGKTS cell cycle regulation BRCA1(INDUCES) 17616665 1 15 13 required for checkpoint function -Notch1 Notch 1 Membrane protein, integral; Motility/polarity/chemotaxis; Oncoprotein; Receptor, misc.; Transcription factor Q01705 18128 2 A3|2 18.91 cM mouse R2253-m2 56852000 AALAGGSrLAFEPPP activity, induced; protein degradation; ubiquitination transcription, induced 25805888 1 1 0 -ZMYM2 ZNF198 Transcription factor Q9UBW7 7750 13q12.11 human K963-sm 12004417 MMSEDEGkTETTNIN molecular association, regulation; intracellular localization PML(INDUCES) 17027752 1 0 0 PLM body formation -STAT3 STAT3 DNA-binding; Motility/polarity/chemotaxis; Nuclear receptor co-regulator; Transcription factor P40763 6774 17q21.2 human Y705-p 448192 DPGSAAPyLKTKFIC activity, induced; protein degradation; molecular association, regulation; methylation; intracellular localization; enzymatic activity, induced; phosphorylation cell cycle regulation; carcinogenesis, induced; apoptosis, induced; cell motility, induced; signaling pathway regulation; cell differentiation, altered; cell growth, induced; cell motility, altered; transcription, inhibited; cell growth, altered; carcinogenesis, altered; carcinogenesis, inhibited; cell growth, inhibited; transcription, induced; transcription, altered; endocytosis, induced; chromatin organization, altered; cell differentiation, induced; apoptosis, inhibited; cytoskeletal reorganization; cell adhesion, altered; autophagy, inhibited NPM1(INDUCES); PLCG1(INDUCES); PIAS3(INDUCES); HP1 alpha(DISRUPTS); DDX5(INDUCES); PKCD(INDUCES); STAT3(INDUCES); STAT1(INDUCES); ER-alpha(INDUCES) DNA(INDUCES) 10845908; 11350938; 11470914; 11536047; 12384432; 12637586; 12684046; 14551213; 15007380; 15077188; 15151905; 15155836; 15465816; 15950906; 16651438; 16951338; 17202361; 17276988; 17360477; 17543278; 17726024; 18198175; 18430728; 18498667; 18519681; 18550668; 18939995; 19147545; 20388777; 20595392; 21057531; 21398617; 21478911; 21586612; 21840932; 22306293; 24793791; 25417160; 25961936; 26028030; 26787900; 27748760; 27941883; 30054295; 30741923; 31170499; 31409371; 31900385; 31956373; 31976162; 32015548; 32029900; 32087696; 32094172; 32164483; 33512408; 33513694; 33687738; 33689932; 33706413; 33774038; 33774344; 33820781; 33824475; 33846242; 33909625; 33947048; 33963314; 33986510; 34015398; 34021045; 34031055; 34066153; 34067421; 34118143; 34244887; 34247191; 34380633; 34411141; 34433042; 34469737; 34480897; 34502195; 34525179; 34531850; 34675408; 34703823; 34744770; 34764490; 34874746; 34900727; 35031324; 35091679; 35184394; 35245627; 35296317; 35367211; 35476936; 35670018; 35712699; 35820864; 35932642; 35995859; 36017196; 36053753; 36066408; 36068200; 36103247; 36362294; 36374556; 36443287; 36509141; 36512575; 36516775; 36630607; 36806887; 36807142; 36922677; 37020037; 37097001; 37126127; 37511611; 8626374 541 75 3065 -Tbc1d1 TBC1D1 DEUBIQUITINASE; GAP; GAP, Rab; Ubiquitin-specific protease Q60949 57915 5 C3.1|5 32.8 cM mouse S660-p 2228809 PRLNPSAsSPNFFKY molecular association, regulation carcinogenesis, induced; cell motility, induced; cell growth, induced; transcription, induced; signaling pathway regulation FZD7(INDUCES) 36371204 3 8 0 induces the WNT pathway -TNFRSF10A TRAIL-R1 Membrane protein, integral O00220 8797 8p21.3 human K273-ub 27581521 SGCGGDPkCMDRVCF receptor internalization, induced; protein degradation; molecular association, regulation carcinogenesis, inhibited; apoptosis, induced; apoptosis, inhibited MARCH1(INDUCES); MARCH8(INDUCES) 23300075; 28671676 2 0 0 proapoptotic effect of TRAIL (chemotherapy) -Ddx41 DDX41 EC 3.6.4.13; Helicase; RNA splicing; RNA-binding; Spliceosome Q91VN6 72935 13|13 B1 mouse K115-ub 27992510 KQLKEEEkILESVAE protein degradation transcription, inhibited 23222971 1 1 0 -CD274 PD-L1 Membrane protein, integral Q9NZQ7 29126 9p24.1 human S279-p 1872811800 CGIQDTNsKKQSDTH protein degradation; molecular association, regulation; ubiquitination carcinogenesis, inhibited ARIH1(INDUCES) 33879767 1 1 0 -NR1I2 PXR DNA-binding; Nuclear receptor O75469 8856 3q13.33 human T57-p 6370304 GYHFNVMtCEGCKGF zf-C4 molecular association, regulation; intracellular localization; activity, inhibited transcription, altered; transcription, inhibited DNA(NOT_REPORTED); DNA(DISRUPTS) 19171678; 19617467 3 0 0 inhibits transcription; PXR T57D (but not T57A) mutant fails to bind to the CYP3A4 promoter -Gsc GSC DNA-binding; Transcription factor Q02591 14836 12 E|12 54.32 cM mouse K183-sm 2887204 ENLFQETkYPDVGTR Homeodomain transcription, inhibited 18336814 1 0 0 SUMO modification inhibition is promoter specific -TRIM63 MURF1 EC 6.3.2.-; EC 6.3.2.19; Ligase; UBIQUITIN LIGASE; Ubiquitin conjugating system; Ubiquitin ligase Q969Q1 84676 1p36.11 human K238-sm 1877577300 ITQEQEKkLSFIEAL intracellular localization 29868881 1 1 0 translocation to nucleus -AATF AATF Nucleolus; RNA-binding; Transcription factor Q9NY61 26574 17q12 human S189-p 3753300 EGDDAEDsQGESEED protein stabilization; molecular association, regulation apoptosis, inhibited; transcription, altered NFkB-p65(INDUCES) DNA(INDUCES) 17157788 1 0 4 -Parp2 PARP2 DNA repair, damage; EC 2.4.2.30; Transferase O88554 11546 14 26.25 cM|14 C1 mouse K37-ac 2459113 DDSPPGKkMRTCQRK molecular association, regulation; intracellular localization; enzymatic activity, inhibited DNA(DISRUPTS) 18436469 1 0 0 -AR AR DNA-binding; Nuclear receptor; Transcription factor P10275 367 Xq12 human K388-sm 2793917 PHPHARIkLENPLDY Androgen_recep protein degradation; molecular association, regulation; ubiquitination; intracellular localization; activity, inhibited carcinogenesis, induced; transcription, induced; transcription, inhibited RAI17(INDUCES) DNA(INDUCES) 11121022; 12177000; 14609956; 15031320; 31620784; 31752909; 32948192 8 1 0 chromatin enrichment independent of ligand activation -Mpl MPL Membrane protein, integral; Receptor, cytokine Q08351 17480 4 D2.1|4 54.61 cM mouse S541-p 3091400 LRDTAALsPSKATVT activity, induced; phosphorylation cell growth, altered 10918061 1 0 0 tyrosine phosphorylation of JAK2 -CREB3 CREB3 Membrane protein, integral; Transcription factor O43889 10488 9p13.3 human S46-p 1827354100 LPLSEVPsDWEVDDL protein degradation 31941600 1 0 0 reduced CREB3 stability -Dab1 DAB1 Adaptor/scaffold P97318 13131 4 C6|4 47.79 cM mouse Y185-p 447959 KQCEQAVyQTILEED molecular association, regulation; intracellular localization neural plasticity; cell differentiation, induced; cell motility, altered; cytoskeletal reorganization Src(INDUCES); SOCS1(INDUCES); PIK3R1(INDUCES) 14517291; 19796633; 22586277 6 0 0 alternatively spliced variants -TJP2 ZO2 Adaptor/scaffold; Motility/polarity/chemotaxis Q9UDY2 9414 9q21.11 human K992-ub 1883981503 NSPPPAFkPEPPKAK protein stabilization; molecular association, regulation occludin(INDUCES); ZO1(INDUCES) 36291162 1 0 0 stability of hZO-2 is regulated by K48 polyubiquitin and K759, K997 ubiquitylation and K730 SUMOylation, mutations in ZO2 ubiquitylation and ylation sites disrupt the interaction with occludin and ZO1as well as tight junction (TJ) barrier function -PKP1 plakophilin 1 Cell adhesion; Motility/polarity/chemotaxis Q13835 5317 1q32.1 human T171-p 27717301 RGTLRKGtLGSKGQK activity, induced; protein stabilization cell motility, induced; cell growth, induced; translation, induced; cell adhesion, inhibited 23444369 1 2 0 -PFKFB3 PFKFB3 Carbohydrate Metabolism - fructose and mannose; EC 2.7.1.105; EC 3.1.3.46; KINASE; Kinase, other; Motility/polarity/chemotaxis; PHOSPHATASE; Phosphatase (non-protein) Q16875 5209 10p15.1 human S461-p 448801 NPLMRRNsVTPLASP molecular association, regulation; intracellular localization; phosphorylation; enzymatic activity, induced carcinogenesis, induced; cell motility, induced; cell growth, induced; apoptosis, inhibited; transcription, induced; signaling pathway regulation KPNA1(INDUCES); HIF1A(INDUCES) 16115917; 23548149; 35072776; 35707221; 35804016 10 47 83 regulates the YAP/TAZ pathway -SRC Src EC 2.7.10.2; KINASE; Kinase, protein; Oncoprotein; Protein kinase, TK; Protein kinase, tyrosine (non-receptor) P12931 6714 20q11.23 human Y522-p 7445100 LQAFLEDyFTSTEPQ enzymatic activity, inhibited 22238675 8 0 0 -RUNX1 AML1 DNA-binding; Oncoprotein; Transcription factor Q01196 861 21q22.12 human K90-ub 95155312 KTLPIAFkVVALGDV Runt protein degradation; intracellular localization carcinogenesis, inhibited; cell growth, inhibited; transcription, inhibited 28536267 1 0 0 -Amfr AMFR EC 6.3.2.-; EC 6.3.2.19; Endoplasmic reticulum; Ligase; Membrane protein, integral; Membrane protein, multi-pass; Motility/polarity/chemotaxis; Receptor, misc.; UBIQUITIN LIGASE; Ubiquitin conjugating system; Ubiquitin ligase Q9R049 23802 8 C5|8 45.96 cM mouse S542-p 469879 ERVPLDLsPRLEETL molecular association, regulation 26337390 1 32 0 S538 phosphorylation limited its ability to induce mitochondrial fusion, regulates ER-mitochondria association and thereby mitofusin degradation and mitochondrial motility -Nrip1 RIP140 Nuclear receptor co-regulator; Transcription, coactivator/corepressor Q8CBD1 268903 16|16 C3.1 mouse K111-ac 459034 SIVNLNVkKEALLAG NRIP1_repr_1 intracellular localization transcription, inhibited 15879431 1 2 0 -EP300 p300 ACETYLTRANSFERASE; Acetyltransferase; EC 2.3.1.48; Motility/polarity/chemotaxis; Nuclear receptor co-regulator; Transcription, coactivator/corepressor Q09472 2033 22q13.2 human R2142-me 2584301 PMQAGVQrAGLPQQQ molecular association, regulation transcription, induced GRIP1(DISRUPTS) 15731352 1 0 0 -RASSF1 RASSF1 iso2 Tumor suppressor Q9NS23-2 11186 3p21.31 human S184-p 7447198 PSSKKPPsLQDARRG molecular association, regulation; intracellular localization cell cycle regulation 24197116 1 2 0 Phosphorylated RASSF1 regulates association with microtubules and ability to induce mitotic arrest. -Pde4d PDE4D iso6 EC 3.1.4.53; Nucleotide Metabolism - purine; Phosphodiesterase P14270-6 24627 rat S67-p 483644 SFLYRSDsDYDLSPK cell cycle regulation 24815749 3 24 3 -Myf6 Myf-6 DNA-binding; Transcription factor P15375 17878 10 D1|10 55.96 cM mouse S42-p 2907503 PGSDGTLsPCQDQMP Basic cell differentiation, altered; transcription, inhibited 14739931 1 0 0 -Glo1 GLO1 Carbohydrate Metabolism - pyruvate; EC 4.4.1.5; Lyase Q9CPU0 109801 17 A3.3|17 15.69 cM mouse T107-p 7106304 ELTHNWGtEDDETQS Glyoxalase protein stabilization; ubiquitination; enzymatic activity, induced 32966793 3 0 0 inhibits ubiquitination -RCC1 RCC1 Cell cycle regulation; GEF; GEF, Ras P18754 1104 1p35.3 human S26-p 2850002 KSKKVKVsHRSHSTE molecular association, regulation KPNA4(DISRUPTS) 18568422 1 0 0 -CNKSR1 CNK1 Adaptor/scaffold; G protein regulator, misc. Q969H4 10256 1p36.11 human Y665-p 33638001 KEQNRELySEGLGAW activity, induced; molecular association, regulation; phosphorylation cell growth, induced; transcription, inhibited; signaling pathway regulation EFNB1(INDUCES); RAF1(INDUCES) 24825906; 26319181 2 1 0 -BRCA2 BRCA2 DNA repair, damage; Nuclear receptor co-regulator; Tumor suppressor P51587 675 13q13.1 human S3291-p 455462 SPICTFVsPAAQKAF molecular association, regulation cell cycle regulation; chromatin organization, altered; DNA repair, inhibited RAD51(DISRUPTS) 15800615; 17515903; 18593900; 32726637 8 1 0 -Aurkc AurC EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, Other; Protein kinase, Ser/Thr (non-receptor) O88445 20871 7 A1|7 4.06 cM mouse T171-p 455456 TPSLRRKtMCGTLDY Pkinase enzymatic activity, inhibited; enzymatic activity, induced cell cycle regulation 11879579; 20484572; 24586209 7 11 83 oocyte meiosis -DVL3 DVL3 Motility/polarity/chemotaxis Q92997 1857 3q27.1 human S643-p 34668102 SHHSLASsLRSHHTH Dsh_C intracellular localization 24993822; 27486244 2 2 0 centrosomal signal for pS697 accumulated throughout the cell cycle, pS280 only in mitotic spindle and not in the interphase centrosome -Daxx DAXX Apoptosis; Nuclear receptor co-regulator; Nucleolus; Transcription, coactivator/corepressor O35613 13163 17 B1|17 17.98 cM mouse S669-p 7249306 TSVQPMPsPPLASVA activity, induced 12529400 1 2 0 Phosphorylation of S669 may downregulate Daxx-mediated transcriptional repression. -MDM2 MDM2 EC 6.3.2.-; EC 6.3.2.19; Inhibitor; Ligase; NEDDYLATION LIGASE; Neddylation Ligase; Nucleolus; Oncoprotein; UBIQUITIN LIGASE; Ubiquitin conjugating system; Ubiquitin ligase Q00987 4193 12q15 human S188-p 453413 RKRHKSDsISLSFDE molecular association, regulation; protein stabilization; ubiquitination signaling pathway regulation ER-beta(INDUCES); CBP(INDUCES) 15169778; 22349818 3 1 1 -CD44 CD44 iso12 Cell adhesion; Membrane protein, integral; Motility/polarity/chemotaxis; Receptor, misc. P16070-12 960 11p13 human S325-p 450988 LNGEASKsQEMVHLV cell adhesion, inhibited 25809479 12 58 37 monocyte-adhesive hyaluronan coats on keratinocytes -Ikbkb IKKB EC 2.7.11.10; KINASE; Kinase, protein; Protein kinase, Other; Protein kinase, Ser/Thr (non-receptor) O88351 16150 8|8 A2 mouse S689-p 3676802 SHPGQLMsQPSSACD molecular association, regulation; phosphorylation PPP2R3C(INDUCES) 20925653 1 1 0 interaction with PPP2R3C (aka G4-1) downregulates IKK-beta activity; S181 phosphorylation increased in S679/682/689/692/697/701/705A mutant -TMOD1 TMOD1 Cell development/differentiation; Contractile; Cytoskeletal; Motility/polarity/chemotaxis P28289 7111 9q22.33 human T54-p 22561900 GLRQKDQtTKAPTGP Tropomodulin cytoskeletal reorganization 19137675 2 0 0 involved in TMOD1 function in actin capping -SF3B1 SF3B1 RNA splicing; RNA-binding; Spliceosome O75533 23451 2q33.1 human T313-p 449360 HGSGWAEtPRTDRGG molecular association, regulation NIPP-1(INDUCES) 12105215 2 32 99 -NDE1 NUDE1 iso1 Cell cycle regulation; Cytoskeletal; Microtubule-binding Q9NXR1-1 54820 16p13.11 human T228-p 449452 GPSSSLNtPGSFRRG NUDE_C molecular association, regulation; intracellular localization ZNF365(DISRUPTS) 16682949 2 10 18 -Ripk1 RIPK1 EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, Ser/Thr (non-receptor); Protein kinase, TKL Q60855 19766 13 A3.3|13 14.01 cM mouse K376-ub 486338 NDRSVQAkLQEEASY ubiquitination; enzymatic activity, inhibited apoptosis, inhibited 31519886; 31519887 11 0 0 promotes NF-?B activation ; NF-?B activation upon TNF treatment, K376-mediated RIPK1 ubiquitination is critical for restraining cell death and inflammation during postnatal development -Scnn1g ENaC-gamma Channel, sodium; Membrane protein, integral; Membrane protein, multi-pass; Transporter, ion channel P37091 24768 1q36 rat T623-p 451220 PGSTVPGtPPPRYNT molecular association, regulation; activity, inhibited NEDD4L(DISRUPTS) 11805112; 16476738 4 0 0 -VIPR1 VIPR1 GPCR, family 2; Membrane protein, integral; Membrane protein, multi-pass; Motility/polarity/chemotaxis; Receptor, GPCR P32241 7433 3p22.1 human S447-p 455662 VSPGARRsSSFQAEV receptor desensitization, altered 14645688 1 2 0 -LRRK2 LRRK2 EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, Ser/Thr (non-receptor); Protein kinase, TKL Q5S007 120892 12q12 human S1444-p 15785707 NIKARASsSPVILVG Roc molecular association, regulation; enzymatic activity, induced 14-3-3 beta(INDUCES); 14-3-3 sigma(INDUCES); 14-3-3 theta(INDUCES); 14-3-3 zeta(INDUCES); 14-3-3 epsilon(INDUCES); 14-3-3 gamma(INDUCES); 14-3-3 eta(INDUCES) 24351927; 32317922 3 2 0 -FOXO1 FOXO1A DNA-binding; Nuclear receptor co-regulator; Oncoprotein; Transcription factor Q12778 2308 13q14.11 human S329-p 448076 STISGRLsPIMTEQD intracellular localization transcription, altered; transcription, inhibited 11311120; 14664696; 20061393; 30971493 11 13 19 -Cry2 CRY2 DNA-binding; Lyase Q9R194 12953 2|2 E1 mouse S557-p 456803 ALSSGPAsPKRKLEA protein degradation; intracellular localization; phosphorylation transcription, induced 15980066; 20123978; 25288642 4 14 1 stimulates phosphorylation of S553; S557 is required for normal expression of a subset of the clock genes; cellular distribution of PER2; required for the circadian time-keeping mechanism -NFKB1 NFkB-p105 DNA-binding; Transcription factor P19838 4790 4q24 human S907-p 451565 QAHSLPLsPASTRQQ activity, induced; protein stabilization; protein processing 12871932; 8522173 2 23 128 Mutation of this site retards the proteolytic processing of p105 that generates active NFkB. -C3AR1 C3aR GPCR, family 1; Membrane protein, integral; Membrane protein, multi-pass; Receptor, GPCR Q16581 719 12p13.31 human S459-p 17548377 GILEAAFsEELTRST receptor desensitization, induced; molecular association, regulation transcription, inhibited ARRB2(INDUCES) 23077507 1 5 0 -PEX5 PEX5 Membrane protein, integral; Receptor, protein translocating P50542 5830 12p13.31 human K209-ub 22249280 VAKVDDPkLANSEFL molecular association, regulation; ubiquitination SQSTM1(INDUCES) 26344566 1 4 0 phosphorylated at S141 becomes ubiquitylated at K209, binding to SQSTM1, and directing the autophagosome to peroxisomes to induce pexophagy -Irs2 IRS2 Adaptor/scaffold; Motility/polarity/chemotaxis P81122 384783 8 A1.1|8 5.35 cM mouse S675-p 472256 SDDYMPMsPTSVSAP molecular association, regulation signaling pathway regulation PIK3R1(DISRUPTS) 23775122 2 22 5 -RRAGA RRAGA G protein regulator, misc. Q7L523 10670 9p22.1 human K142-ub 41159601 DQRDLIFkEREEDLR Gtr1_RagA molecular association, regulation; phosphorylation autophagy, induced; signaling pathway regulation NPRL3(INDUCES); Raptor(DISRUPTS); DEPDC5(INDUCES); NPRL2(INDUCES) 25936802 1 4 0 interaction with GATOR1 complex, regulates mTORC1 signaling, regulates p70S6K phosphorylation -NOS3 eNOS Amino Acid Metabolism - arginine and proline; EC 1.14.13.39; Oxidoreductase P29474 4846 7q36.1 human Y657-p 2811400 FGLGSRAyPHFCAFA Flavodoxin_1 enzymatic activity, inhibited 18483407; 19934023; 28444132 6 1 0 -Gch1 GCH1 Cofactor and Vitamin Metabolism - folate biosynthesis; EC 3.5.4.16; Hydrolase P22288 29244 15p14 rat S130-p 10428814 VKDIDMFsMCEHHLV GTP_cyclohydroI enzymatic activity, induced 19762783 1 0 0 -MYF5 Myf-5 DNA-binding; Transcription factor P13349 4617 12q21.31 human S49-p 457384 HKAELQGsDEDEHVR Basic activity, induced 9461343 1 0 0 -PXN PXN iso2 Adaptor/scaffold; Cell adhesion; Cytoskeletal; Motility/polarity/chemotaxis P49023-2 5829 12q24.23 human Y31-p 448785 FLSEETPySYPTGNH activity, induced; protein degradation; molecular association, regulation; phosphorylation cell cycle regulation; cell motility, altered; cytoskeletal reorganization; transcription, altered Src(INDUCES); CRKL(INDUCES) 15870699; 16491114; 17046825; 17574549; 18045996; 20628053; 7493940 49 8 64 Paxillin phosphorylation induces ERK activation.; essential for EGFR-mediated Erk1/2 activation and cell proliferation -AURKB AurB EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, Other; Protein kinase, Ser/Thr (non-receptor) Q96GD4 9212 17p13.1 human K202-sm 25087008 KVIHRDIkPENLLLG Pkinase phosphorylation; enzymatic activity, induced 21554500 1 1 0 induces phosphorylation at T232 -MYC Myc DNA-binding; Nucleolus; Oncoprotein; Transcription factor P01106 4609 8q24.21 human K445-sm 40724407 RREQLKHkLEQLRNS Myc-LZ protein degradation; ubiquitination transcription, inhibited 25895136 1 2 0 -TAL1 TAL1 DNA-binding; Oncoprotein; Transcription factor P17542 6886 1p33 human T90-p 457536 EARHRVPtTELCRPP protein degradation; molecular association, regulation; ubiquitination translation, induced CHIP(INDUCES) 15930267; 19406989 2 0 10 -TPM1 TPM1 Actin-binding; Motility/polarity/chemotaxis; Motor P09493 7168 15q22.2 human S283-p 451804 HALNDMTsI______ Tropomyosin molecular association, regulation carcinogenesis, inhibited; cell motility, inhibited; cytoskeletal reorganization TNNT1(DISRUPTS); TPM1(INDUCES); Actinfilin(INDUCES); Actinfilin(DISRUPTS) 17895359; 23157718; 33389411 11 15 94 induces interaction with actin at lower pH and decreases interaction at pH 7.3; Induce actin fibers formation; decreases cancer cells migration through the endothelial barrier in response to H2O2 -Bcar1 P130Cas Adaptor/scaffold; Motility/polarity/chemotaxis Q63767 25414 19q12 rat Y762-p 448399 EGGWMEDyDYVHLQG CAS_C molecular association, regulation; phosphorylation Src(INDUCES); Lck(INDUCES); Fyn(INDUCES) 16245368; 8621540; 9360983 6 2 24 -PPIF PPIF Cyclophilin; EC 5.2.1.8; Isomerase; Mitochondrial P30405 10105 10q22.3 human S31-p 40256000 LPAARACsKGSGDPS enzymatic activity, induced apoptosis, inhibited 25650317 1 0 0 mitochondrial bioenergetics, organelle membrane potential -FSCN1 fascin Actin-binding; Cytoskeletal; Motility/polarity/chemotaxis Q16658 6624 7p22.1 human K471-ub 8102207 KVGGRYLkGDHAGVL Fascin cytoskeletal reorganization 27879315 1 4 5 fascin bundling activity -Gsc GSC DNA-binding; Transcription factor Q02591 14836 12 E|12 54.32 cM mouse K203-sm 2887205 KVHLREEkVEVWFKN Homeodomain transcription, inhibited 18336814 1 0 0 SUMO modification inhibition is promoter specific -Nfatc2 NFAT1 DNA-binding; Transcription factor Q60591 18019 2 H3|2 88.91 cM mouse S328-p 447853 PSKIWKTsPDPTPVS transcription, inhibited 11030334 0 18 0 -RBBP8 CtIP EC 3.1.-.-; Transcription, coactivator/corepressor Q99708 5932 18q11.2 human T693-p 1868101003 ETVDMDCtLVSETVL cell cycle regulation; DNA repair, inhibited 30202980 1 0 0 supress DSB end resection -CTNND1 CTNND1 Actin-binding; Adaptor/scaffold; Cell adhesion; G protein regulator, misc.; Motility/polarity/chemotaxis O60716 1500 11q12.1 human T310-p 450457 GTARRTGtPSDPRRR molecular association, regulation; intracellular localization carcinogenesis, induced; cell motility, induced; cell adhesion, inhibited SMURF1(INDUCES); CDH1(DISRUPTS) 26302406; 30808747; 32010791; 32589661 10 7 28 -LATS2 LATS2 EC 2.7.11.1; KINASE; Kinase, protein; Nuclear receptor co-regulator; Protein kinase, AGC; Protein kinase, Ser/Thr (non-receptor); Tumor suppressor Q9NRM7 26524 13q12.11 human T1041-p 31843001 EHAFYEFtFRRFFDD Pkinase_C activity, induced; phosphorylation; enzymatic activity, induced carcinogenesis, inhibited; cell growth, inhibited; signaling pathway regulation 24362629; 30800215; 34465890 7 0 0 induces PRPS1 phosphorylation; Hippo pathway; in SAS cell line -Lpin1 LPIN1 EC 3.1.3.4; Phosphatase, lipid Q91ZP3 14245 12 A1.1|12 7.9 cM mouse S487-p 62856003 GIDSGVEsTSDSLRD molecular association, regulation BTRC(INDUCES) 28049764 1 0 0 -BBC3 PUMA Apoptosis; Mitochondrial Q9BXH1 27113 19q13.32 human Y58-p 29674706 PTLLPAAyLCAPTAP PUMA protein degradation; intracellular localization cell growth, induced; apoptosis, inhibited 24236056 1 0 0 -Dab1 DAB1 iso2 Adaptor/scaffold P97318-2 13131 4 C6|4 47.79 cM mouse T484-p 479421 PSTNSPPtPAPRQSS phosphorylation 16529723 1 0 0 inhibits tyrosine phosphorylation -HMGB1 HMGB1 DNA repair, damage; Nuclear receptor co-regulator P09429 3146 13q12.3 human T51-p 36840087 KCSERWKtMSAKEKG HMG_box_2 molecular association, regulation RPS3(INDUCES) 35632744 1 2 0 inducees HMGB1 secretion -BLM BLM DNA repair, damage; DNA replication; EC 3.6.4.12; Helicase P54132 641 15q26.1 human K331-sm 2293706 DLDTSDRkEDVLSTS BLM_N intracellular localization; phosphorylation chromatin organization, altered 15829507; 31171703 3 2 0 localization to PML bodies determined by the ratio of SUMO and SIM in telomere clustering scaffolds; inhibits phosphorylation of H2AX -KCNA4 Kv1.4 Channel, potassium; Membrane protein, integral; Membrane protein, multi-pass P22459 3739 11p14.1 human T601-p 456509 LKKFRSStSSSLGDK protein degradation 15955806 1 0 0 phosphorylation of site induces endocytosis of the Kv1.4 channel. -FBXO22 FBXO22 Ligase; UBIQUITIN LIGASE; Ubiquitin conjugating system; Ubiquitin ligase Q8NEZ5 26263 15q24.2 human S162-p 1875332204 VTPMGSGsNRPQEIE protein stabilization carcinogenesis, inhibited 34795058 1 1 0 induces PD-L1 degradation -Mefv pyrin Actin-binding Q9JJ26 54483 16 A1|16 2.18 cM mouse S241-p 455899 SGKKRPRsLEITTYS molecular association, regulation; activity, inhibited 14-3-3 epsilon(INDUCES) 27482109 8 7 0 dephosphorylation triggers 14-3-3 dissociation, activation, formation of an oligomeric Pyrin inflammasome complex -RAD52 RAD52 DNA repair, damage P43351 5893 12p13.33 human K262-ac 971232902 HQRKLRQkQLQQQFR molecular association, regulation; intracellular localization DNA repair, induced RFA2(INDUCES); RPA3(INDUCES); RAD51(INDUCES); RPA1(INDUCES) 29590107 1 1 0 accumulation of RAD52 at DSB sites -YBX1 YB-1 RNA processing; RNA splicing; RNA-binding; Transcription factor P67809 4904 1p34.2 human R205-m2 1876986200 MRRPYGRrPQYSNPP molecular association, regulation cell motility, induced; cell growth, induced; transcription, induced NFkB-p65(INDUCES) DNA(INDUCES) 32985589 1 1 0 -RRM2 RRM2 EC 1.17.4.1; Nucleotide Metabolism - purine; Nucleotide Metabolism - pyrimidine; Other Amino Acids Metabolism - glutathione; Oxidoreductase P31350 6241 2p25.1 human S20-p 457399 DPQQLQLsPLKGLSL transcription, induced; signaling pathway regulation 17693683 4 79 81 Beta-catenin-LEF/TCF transcriptional activity ; Wnt signaling pathway -MAP2K2 MEK2 EC 2.7.12.2; KINASE; Kinase, protein; Protein kinase, STE; Protein kinase, dual-specificity (non-receptor) P36507 5605 19p13.3 human S222-p 448073 VSGQLIDsMANSFVG Pkinase enzymatic activity, induced carcinogenesis, induced; cell growth, induced; signaling pathway regulation 19106095; 21893193; 34262144 62 12 83 -WASHC1 WASH1 A8K0Z3 100287171 9p24.3 human K220-ub 21357516 DAPLSISkREQLEQQ WASH_WAHD intracellular localization cytoskeletal reorganization 23452853 1 4 0 regulation of F-actin nucleation and retromer-mediated transport, endosomal protein recycling -Bmal1 BMAL1 DNA-binding; Transcription factor Q9WTL8 11865 7 F1|7 59.17 cM mouse K544-ac 1968606 DASSPGGkKILNGGT protein stabilization; molecular association, regulation; phosphorylation transcription, induced; transcription, inhibited; signaling pathway regulation; transcription, altered CRY1(INDUCES) 18075593; 18662547; 24089055 8 0 0 regulation of mammalian circadian clock through MTA1-SIRT1-BMAL1 axis -Ulk1 ULK1 Autophagy; EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, Other; Protein kinase, Ser/Thr (non-receptor) O70405 22241 5|5 F mouse S555-p 3176155 GLGCRLHsAPNLSDF activity, induced; molecular association, regulation; intracellular localization; enzymatic activity, induced; phosphorylation carcinogenesis, inhibited; autophagy, induced; autophagy, inhibited; autophagy, altered; transcription, altered; signaling pathway regulation 14-3-3 beta(INDUCES); RAB9A(INDUCES) 21205641; 21819378; 30332646; 30511961; 32854424; 33528041; 33779513; 34497121; 34598317; 34760883; 35115920 61 26 48 -BAG1 BAG1 Motility/polarity/chemotaxis; Nuclear receptor co-regulator Q99933 573 9p13.3 human K195-ub 1873691400 QKLIFKGkSLKEMET ubiquitin carcinogenesis, induced; cell growth, induced 12874020 1 0 0 -Mettl14 METTL14 EC 2.1.1.62; METHYLTRANSFERASE; Methyltransferase Q3UIK4 210529 3|3 G1 mouse R255-m1 1881467800 LRKWGYRrCEDICWI protein stabilization cell differentiation, induced 34145242 1 1 0 stabilizes the methyltransferase complex to its substrate RNA, mESC endoderm differentiation -MACC1 MACC1 Q6ZN28 346389 7p21.1 human Y793-p 1874020222 KPAYDFLyTWSAHYG phosphorylation carcinogenesis, induced; cell motility, induced; cell growth, induced; transcription, induced 34247190 1 1 0 -Ap2m1 AP2M1 Adaptor/scaffold; Vesicle P84091 11773 16|16 A3 mouse T156-p 448782 SQITSQVtGQIGWRR protein stabilization; protein conformation endocytosis, induced; signaling pathway regulation 31217281; 31905947 9 33 29 -PARP1 PARP1 DNA repair, damage; EC 2.4.2.30; Nuclear envelope; Nuclear receptor co-regulator; Nucleolus; Transferase P09874 142 1q42.12 human K508-ac 459005 AALSKKSkGQVKEEG molecular association, regulation transcription, induced NFkB-p105(INDUCES) 16204234 1 1 0 -Rela NFkB-p65 DNA-binding; Nuclear receptor co-regulator; Transcription factor Q7TQN4 309165 1q43 rat S468-p 451145 GVFTDLAsVDNSEFQ transcription, inhibited 21550382 22 0 0 -Prkaa1 AMPKA1 Autophagy; EC 2.7.11.1; EC 2.7.11.26; EC 2.7.11.27; EC 2.7.11.31; KINASE; Kinase, protein; Protein kinase, CAMK; Protein kinase, Ser/Thr (non-receptor) P54645 65248 2q16 rat Y441-p 457338 EWKVVNPyYLRVRRK AdenylateSensor enzymatic activity, inhibited 27626315 1 0 2 -ROCK1 ROCK1 EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, AGC; Protein kinase, Ser/Thr (non-receptor) Q13464 6093 18q11.1 human T455-p 2526076 EMEQKCRtSNIKLDK signaling pathway regulation 34530870 1 2 0 induces RhoA/ROCK1/MYPT1 signaling -KLF11 TIEG2 C2H2-type zinc finger protein; DNA-binding; Transcription factor O14901 8462 2p25.1 human S166-p 456011 GLEPVPSsPCRAKGT molecular association, regulation SIN3A(DISRUPTS) 12006497 1 0 0 -Elk1 ELK1 DNA-binding; Transcription factor A4GTP4 314436 Xq11 rat T160-p 2028401 MRSGLYStFTIQSLQ activity, inhibited transcription, inhibited SRF(DISRUPTS) 18088355 1 0 0 -EGR1 EGR1 C2H2-type zinc finger protein; DNA-binding; Transcription factor P18146 1958 5q31.2 human S196-p 11423701 PLSCAVPsNDSSPIY DUF3446 transcription, altered DNA(DISRUPTS) 8662759 1 0 0 -RPL11 RPL11 Motility/polarity/chemotaxis; Nucleolus; Ribosomal; Translation P62913 6135 1p36.11 human K38-ne 12067612 DRLTRAAkVLEQLTG Ribosomal_L5 protein stabilization; intracellular localization 19713960 1 0 0 -H3C1 H3 DNA-binding P68431 8350 6p22.2 human K4-ub 1880545300 ____ARTkQTARKST protein degradation carcinogenesis, induced; chromatin organization, altered; cell growth, induced; transcription, induced 28507061 1 0 0 -CEACAM1 CEACAM1 Cell adhesion; Immunoglobulin superfamily; Membrane protein, integral; Motility/polarity/chemotaxis P13688 634 19q13.2 human T492-p 473038 PNKMNEVtYSTLNFE apoptosis, altered; cytoskeletal reorganization 17192268 1 0 0 plays a role in cell polarization and lumen formation -BMAL1 BMAL1 DNA-binding; Transcription factor O00327 406 11p15.3 human S42-p 25230400 CNRKRKGsSTDYQES molecular association, regulation carcinogenesis, inhibited; cell growth, inhibited; cell motility, inhibited; transcription, inhibited DNA(DISRUPTS) 37123229 4 3 2 -Mtor mTOR Autophagy; EC 2.7.11.1; KINASE; Kinase, protein; Motility/polarity/chemotaxis; Protein kinase, Ser/Thr (non-receptor); Protein kinase, atypical Q9JLN9 56717 4 E2|4 78.76 cM mouse S1261-p 458285 PMKKLHVsTINLQKA phosphorylation cell growth, induced; signaling pathway regulation 19487463 5 29 5 induces phosphorylation of itself and of substrate, mTORC1 signaling -GJA1 GJA1 Channel, misc.; Membrane protein, integral; Membrane protein, multi-pass; Motility/polarity/chemotaxis P17302 2697 6q22.31 human S369-p 459208 RPSSRASsRASSRPR intracellular localization; protein conformation 23828237; 29259079 15 8 2 gap junction communication; trophoblast cell fusion and syncytial hormone production; assembly of Cx43 at the plasma membrane -KAT5 Tip60 ACETYLTRANSFERASE; Acetyltransferase; EC 2.3.1.48; Nuclear receptor co-regulator; Nucleolus Q92993 10524 11q13.1 human K268-ac 1872267900 YLCEFCLkYGRSLKC zf-MYST protein degradation apoptosis, inhibited 16001085 1 0 0 Tip60 targeting by HIV Tat -Arhgap12 ARHGAP12 GAP; GAP, Rac/Rho Q8C0D4 75415 18|18 A1 mouse T228-p 2424903 STEQMRAtTPPNQGR SH3-WW_linker cell cycle regulation; cell motility, altered 18515860 0 20 25 -RELA NFkB-p65 DNA-binding; Nuclear receptor co-regulator; Transcription factor Q04206 5970 11q13.1 human S42-p 25302155 RYKCEGRsAGSIPGE RHD_DNA_bind molecular association, regulation transcription, inhibited DNA(DISRUPTS) 27466442 1 2 1 -NGFR NGFR Membrane protein, integral; Receptor, misc. P08138 4804 17q21.33 human S303-p 10432300 PEGEKLHsDSGISVD molecular association, regulation; intracellular localization carcinogenesis, induced; cytoskeletal reorganization; cell growth, altered CLIM1(INDUCES) 12682012; 26119933 2 1 0 inactivation of Rho ; NGFR-mediated glioma invasion ; translocation to lipid rafts -Klf1 KLF1 C2H2-type zinc finger protein; DNA-binding; Transcription factor P46099 16596 8 41.3 cM|8 C3 mouse K284-ac 461016 CGHEGCGkSYSKSSH zf-C2H2 cell differentiation, induced; transcription, induced 12920040 3 0 0 -BMAL1 BMAL1 DNA-binding; Transcription factor O00327 406 11p15.3 human S17-p 12575203 STISDFMsPGPTDLL protein degradation transcription, altered 20049328 1 0 0 stabilization of BMAL1 protein leads to reduction in its transcription activation ability -FSCN1 fascin Actin-binding; Cytoskeletal; Motility/polarity/chemotaxis Q16658 6624 7p22.1 human Y23-p 6157484 LINCGNKyLTAEAFG Fascin cell growth, inhibited; cytoskeletal reorganization; cell motility, inhibited 28251354 1 2 1 reduce cell proliferation, cell migration and ?lopodia formation -Epor EPOR Membrane protein, integral; Receptor, cytokine P14753 13857 9 A3|9 7.93 cM mouse Y453-p 455531 PTPPHLKyLYLVVSD molecular association, regulation; receptor internalization, altered PIK3R2(INDUCES); PIK3R1(INDUCES) 19336760 6 0 0 required for optimal PIK3R1/2 binding -CYCS CYCS Apoptosis; Mitochondrial; Oxidoreductase; PHOSPHATASE; Protein phosphatase, Ser/Thr (non-receptor) P00004 100053958 horse K28-ac 1186601 VEKGGKHkTGPNLHG Cytochrom_C enzymatic activity, induced 19645667 1 3 10 -Irs2 IRS2 Adaptor/scaffold; Motility/polarity/chemotaxis P81122 384783 8 A1.1|8 5.35 cM mouse Y624-p 3597307 PKVAYNPyPEDYGDI molecular association, regulation INSR(DISRUPTS) 9195949 1 2 2 -EWSR1 EWS Oncoprotein; RNA-binding; Transcription, coactivator/corepressor Q01844 2130 22q12.2 human S266-p 448028 SSYGQQSsFRQDHPS intracellular localization transcription, induced 11313922 2 0 0 -RELA NFkB-p65 DNA-binding; Nuclear receptor co-regulator; Transcription factor Q04206 5970 11q13.1 human K218-me 31094534 EIFLLCDkVQKEDIE RHD_dimer molecular association, regulation transcription, induced DNA(INDUCES) 23904479 1 0 0 -DKC1 dyskerin EC 5.4.99.-; Isomerase; Lyase; Nucleolus; RNA processing; RNA-binding O60832 1736 Xq28 human K39-sm 31910300 HAEEFLIkPESKVAK protein stabilization; enzymatic activity, induced 23660516 1 0 0 -RAD52 RAD52 DNA repair, damage P43351 5893 12p13.33 human K177-ac 971232913 DYLRSLNkLPRQLPL Rad52_Rad22 molecular association, regulation; intracellular localization DNA repair, induced RFA2(INDUCES); RPA3(INDUCES); RAD51(INDUCES); RPA1(INDUCES) 29590107 1 1 0 accumulation of RAD52 at DSB sites -GLI1 GLI1 C2H2-type zinc finger protein; Oncoprotein; Transcription factor P08151 2735 12q13.3 human T1074-p 41595601 QRGSSGHtPPPSGPP protein degradation; molecular association, regulation; ubiquitination; intracellular localization; activity, inhibited carcinogenesis, inhibited; cell growth, inhibited; transcription, inhibited BTRC(INDUCES); SUFU(INDUCES) DNA(DISRUPTS) 26190112; 28562331; 29662197; 32102879 5 2 0 -MAP3K5 ASK1 EC 2.7.11.25; KINASE; Kinase, protein; Protein kinase, STE; Protein kinase, Ser/Thr (non-receptor) Q99683 4217 6q23.3 human Y718-p 458209 IPERDSRySQPLHEE Pkinase protein degradation; molecular association, regulation SOCS1(INDUCES) 19287004 1 0 0 SHP2 dephosphorylation of ASK1 Y798 disrupts binding of ASK1 to SOCS1 and induces apoptosis. -Smad1 SMAD1 DNA-binding; Transcription factor P97588 25671 19q11 rat S459-p 36133591 KVLTQMGsPHNPISS molecular association, regulation; intracellular localization cell cycle regulation Mad1(INDUCES) 30782962 1 1 0 recruits RZZ complex to the kinetochores -Wee2 WEE1B EC 2.7.10.2; KINASE; Kinase, protein; Protein kinase, Other; Protein kinase, Ser/Thr (non-receptor); Protein kinase, tyrosine (non-receptor) Q66JT0 381759 6|6 B1 mouse S15-p 456697 QGLNKKLsFSFCEED enzymatic activity, induced cell cycle regulation 23616086 3 0 0 -TBK1 TBK1 EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, Other; Protein kinase, Ser/Thr (non-receptor) Q9UHD2 29110 12q14.2 human S716-p 4271179 HILERFGsLTMDGGL phosphorylation; enzymatic activity, induced carcinogenesis, altered; cell growth, induced; signaling pathway regulation 31792381 2 14 6 -Creb1 CREB iso1 DNA-binding; Transcription factor P15337-1 81646 9q32 rat S121-p 451811 SVDSVTDsQKRREIL pKID protein degradation 16782881 12 0 0 required for PDGF-induced protein ubiquitination -Ephb1 EphB1 EC 2.7.10.1; KINASE; Kinase, protein; Membrane protein, integral; Protein kinase, TK; Protein kinase, tyrosine (receptor) P09759 24338 8q32 rat Y594-p 449995 GSPGMKIyIDPFTYE EphA2_TM molecular association, regulation NCK1(INDUCES) 23181695 5 16 117 -SLFN11 SLFN11 Q7Z7L1 91607 17q12 human T230-p 1869008604 FQEYVKRtIPEYVPA AlbA_2 activity, inhibited translation, induced 31395656 1 1 0 p24 expression and activity depend on S753 site -SNCA SNCA Adaptor/scaffold P37840 6622 4q22.1 human S129-p 448278 NEAYEMPsEEGYQDY Synuclein receptor internalization, induced; protein stabilization; molecular association, regulation; phosphorylation; activity, induced; ubiquitination; intracellular localization; protein conformation endocytosis, altered; exocytosis, induced; apoptosis, induced; apoptosis, inhibited; autophagy, altered RAB3A(INDUCES); SNCA(DISRUPTS); SNCAIP(INDUCES); PARK2(INDUCES); SNCA(INDUCES) DNA(DISRUPTS) 15944382; 16847063; 17652097; 18178617; 18343814; 18562315; 21400129; 21849493; 22079575; 25657004; 26719332; 31933723; 33979611; 34115198; 34220490; 34973339; 35353605; 35809645; 36162505; 36304930 143 7 0 -HAS2 HAS2 EC 2.4.1.212; Membrane protein, integral; Membrane protein, multi-pass; Motility/polarity/chemotaxis; Transferase Q92819 3037 8q24.13 human T328-p 1870773104 VLSLGYAtKYTARSK Chitin_synth_2 intracellular localization; enzymatic activity, induced 32993960 1 1 0 Regulates localization and membrane transport -KHDRBS1 KHDRBS1 RNA-binding Q07666 10657 1p35.2 human R320-m1 476773 LVRGTPVrGAITRGA intracellular localization 12529443 1 5 23 -MYCN N-Myc DNA-binding; Oncoprotein; Transcription factor P04198 4613 2p24.3 human S62-p 448222 LLPTPPLsPSRGFAE Myc_N protein degradation; protein stabilization; molecular association, regulation; ubiquitination; intracellular localization carcinogenesis, induced; cell growth, induced AurA(INDUCES) 19111882; 25100564; 25175806; 27571165; 34258104 6 20 13 inhibits ubiquitination -CIB1 CIB1 Cell adhesion; Motility/polarity/chemotaxis Q99828 10519 15q26.1 human S78-p 479918 ERICRVFsTSPAKDS carcinogenesis, induced; cell motility, induced 23503467 1 0 2 -SPTBN4 SPTBN4 Cytoskeletal; Motility/polarity/chemotaxis Q9H254 57731 19q13.2 human S2254-p 481487 RRPERQEsVDQSEEA protein degradation; molecular association, regulation cell growth, induced; transcription, induced; signaling pathway regulation STAT3(DISRUPTS) 34153319 1 8 0 induces ?IV-spectrin/STAT3 pathway -Dpysl2 CRMP-2 Microtubule-binding; Motility/polarity/chemotaxis P47942 25416 15p12 rat T514-p 454386 SVTPKTVtPASSAKT receptor recycling, inhibited; protein degradation; molecular association, regulation; activity, inhibited neural plasticity; cytoskeletal reorganization TUBA1A(DISRUPTS); TUBA1B(DISRUPTS); CRMP-4(DISRUPTS); endophilin A2(DISRUPTS); CRMP-1(DISRUPTS); ROCK2(DISRUPTS); SLC25A4(DISRUPTS) 15652488; 18220421; 24036111; 32848595; 33575839 33 36 35 regulates axonogenesis -PIM1 Pim1 EC 2.7.11.1; KINASE; Kinase, protein; Oncoprotein; Protein kinase, CAMK; Protein kinase, Ser/Thr (non-receptor) P11309 5292 6p21.2 human K169-sm 1873037706 GVLHRDIkDENILID Pkinase protein degradation; ubiquitination; enzymatic activity, induced 28620180 1 0 0 -Syngap1 SynGAP iso3 GAP; GAP, Ras Q9QUH6-3 192117 20p12 rat S781-p 18710211 KMLSVNKsVSMLDLQ DUF3498 molecular association, regulation; intracellular localization HRas(INDUCES) 21382555 1 1 1 -ABI3 ABI3 Adaptor/scaffold Q9P2A4 51225 17q21.32 human S213-p 4755282 SSAFSLAsAGSAEGV protein stabilization; molecular association, regulation carcinogenesis, induced; cell motility, induced FAT10(INDUCES) 36926204 1 2 0 -PHGDH PHGDH Amino Acid Metabolism - glycine, serine and threonine; Cell development/differentiation; EC 1.1.1.95; Oxidoreductase O43175 26227 1p12 human K58-ac 36311760 LIVRSATkVTADVIN 2-Hacid_dh protein degradation carcinogenesis, inhibited 32783943 1 2 0 -HIF3A HIF3A Transcription factor; Tumor suppressor Q9Y2N7 64344 19q13.32 human K570-ub 486276 SPMAGARkRTLAQSS protein degradation 12538644 1 0 0 -Stat5a STAT5A DNA-binding; Motility/polarity/chemotaxis; Oncoprotein; Transcription factor P42230 20850 11 D|11 63.77 cM mouse S128-p 456899 REANNCSsPAGVLVD phosphorylation transcription, induced DNA(INDUCES) 15863494 1 6 0 Phosphorylation of S127 or S128 is required for transcription. Phosphorylation of S127/S128 required for phosphorylation on Y694 and binding of DNA. -Map3k3 MEKK3 EC 2.7.11.25; KINASE; Kinase, protein; Protein kinase, STE; Protein kinase, Ser/Thr (non-receptor) Q61084 26406 11|11 E1 mouse S337-p 468184 DPRGRLRsADSENAL enzymatic activity, inhibited 12761204 2 32 46 -Ripk3 RIPK3 EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, Ser/Thr (non-receptor); Protein kinase, TKL Q9QZL0 56532 14|14 C3 mouse K264-ub 53415400 TPGLEKLkELMIHCW Pkinase protein degradation apoptosis, induced 26786097 1 0 0 induces necroptosis -MTHFD2 MTHFD2 Carbohydrate Metabolism - glyoxylate and dicarboxylate; Cofactor and Vitamin Metabolism - one carbon pool by folate; EC 1.5.1.15; EC 3.5.4.9; Hydrolase; Mitochondrial; Oxidoreductase P13995 10797 2p13.1 human K50-ac 461171 RKLAQQIkQEVRQEV THF_DHG_CYH protein stabilization carcinogenesis, induced; cell growth, induced 35349697 1 6 8 K50 acetylation supports NADPH production and breast cancer tumor growth, -TUBG1 TUBG1 Cytoskeletal; Motility/polarity/chemotaxis P23258 7283 17q21.2 human S385-p 34424909 MANHTSIsSLFERTC Tubulin_C molecular association, regulation; intracellular localization cell cycle regulation; transcription, altered TUBG1(DISRUPTS) 24942739 1 0 0 transient increase in nuclear TUBG1 -PAK2 PAK2 EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, STE; Protein kinase, Ser/Thr (non-receptor) Q13177 5062 3q29 human Y194-p 15413016 PDHTKSIyTRSVIDP enzymatic activity, induced 12215529 2 0 18 -Slc5a5 SLC5A5 Membrane protein, integral; Membrane protein, multi-pass; Transporter; Transporter, SLC family Q63008 114613 16p14 rat T49-p 990310 RSADDFFtGGRQLAA SSF protein conformation 17913707 1 1 0 -NFE2L2 NRF2 DNA-binding; Transcription factor Q16236 4780 2q31.2 human K438-ac 7106326 PVSPGHRkTPFTKDK molecular association, regulation transcription, induced DNA(INDUCES) 19273602 1 1 0 -CDH1 CDH1 Cell adhesion; Membrane protein, integral; Motility/polarity/chemotaxis; UBIQUITIN LIGASE; Ubiquitin ligase P12830 999 16q22.1 human Y755-p 456026 TRDNVYYyDEEGGGE endocytosis, induced 29311227 1 1 46 -APAF1 APAF Apoptosis O14727 317 12q23.1 human S268-p 23003805 LLTTRDKsVTDSVMG NB-ARC molecular association, regulation apoptosis, inhibited 14-3-3 epsilon(INDUCES); CYC1(DISRUPTS) 22246185 1 0 0 decreased cellular response to cytochrome c -Bmi1 BMI1 EC 6.3.2.-; Ligase; Motility/polarity/chemotaxis; Oncoprotein; UBIQUITIN LIGASE; Ubiquitin conjugating system; Ubiquitin ligase P25916 12151 2 A3|2 12.9 cM mouse S314-p 6150348 ASRPRKSsLNGSSAT cell cycle regulation; carcinogenesis, inhibited; cell growth, inhibited; transcription, induced 35650206 2 1 50 -Gria1 GluR1 Channel, calcium; Channel, ligand-gated; Membrane protein, integral; Membrane protein, multi-pass P19490 50592 10q22 rat S863-p 448566 TSTLPRNsGAGASGG activity, induced; receptor internalization, altered; intracellular localization; receptor internalization, inhibited neural plasticity; cell motility, induced GluR2(INDUCES) 10627585; 11943807; 12536214; 15630695; 16272153; 17472959; 21564097; 23461423; 26460013; 26626486; 28768764; 33593997; 35835216; 8663994 102 0 0 -ROCK2 ROCK2 EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, AGC; Protein kinase, Ser/Thr (non-receptor) O75116 9475 2p25.1 human S1379-p 3892345 NQSIRRPsRQLAPNK enzymatic activity, inhibited cytoskeletal reorganization 24610576 2 7 16 PGE2-dependent blockade of actomyosin fiber formation -NCF1 p47phox EC 1.-.-.-; Oxidoreductase P14598 653361 7q11.23 human S379-p 451498 DLILNRCsESTKRKL p47_phox_C molecular association, regulation; intracellular localization; protein conformation; enzymatic activity, induced; phosphorylation carcinogenesis, induced; cell growth, induced; signaling pathway regulation CYBA(INDUCES); p67phox(DISRUPTS); p40phox(DISRUPTS); TRAF4(INDUCES) 12056906; 15657040; 16297854; 22460559; 24632950; 24970888; 7657821 9 1 0 induces NOX1 activation and ROS generation -Foxo1 FOXO1A DNA-binding; Nuclear receptor co-regulator; Oncoprotein; Transcription factor Q9R1E0 56458 3 C|3 23.19 cM mouse S413-p 478368 PPNTSLNsPSPNYSK molecular association, regulation; intracellular localization transcription, inhibited DUSP6(INDUCES) 22503562; 22848439 4 1 0 -Wnk1 WNK1 EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, Other; Protein kinase, Ser/Thr (non-receptor) Q9JIH7 116477 4q42 rat S378-p 456474 LATLKRAsFAKSVIG Pkinase enzymatic activity, induced 12374799 3 7 0 -GMNN Geminin Cell cycle regulation; Motility/polarity/chemotaxis O75496 51053 6p22.3 human S184-p 25535401 EEETVEDsLVEDSEI Geminin molecular association, regulation HOXC9(INDUCES) 22615398 1 1 0 -Hsf1 HSF1 DNA-binding; Transcription factor P38532 15499 15 D3|15 35.95 cM mouse S415-p 455264 SALLDLFsPSVTMPD Vert_HS_TF intracellular localization 15661742 5 1 0 -Ctnnb1 CTNNB1 Actin-binding; Cell adhesion; Motility/polarity/chemotaxis; Nuclear receptor co-regulator; Oncoprotein; Transcription factor Q02248 12387 9 F4|9 72.19 cM mouse S33-p 447487 QQQSYLDsGIHSGAT activity, induced; protein degradation; ubiquitination cell differentiation, inhibited; carcinogenesis, inhibited; cell growth, inhibited; apoptosis, inhibited; cell motility, inhibited; transcription, altered 12370820; 34642308; 35013220; 35637461; 9233789 112 3 2 -BECN1 beclin 1 Adaptor/scaffold; Autophagy; Membrane protein, peripheral Q14457 8678 17q21.31 human K117-ub 14991107 ENLSRRLkVTGDLFD BH3 autophagy, induced 20501938 2 0 0 -HNRNPC hnRNP C1/C2 iso2 RNA splicing; RNA-binding; Spliceosome P07910-2 3183 14q11.2 human K237-sm 12057403 KKDETNVkMESEGGA molecular association, regulation DNA(DISRUPTS) 15082759 1 2 0 -Ripk4 ANKRD3 EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, Ser/Thr (non-receptor); Protein kinase, TKL Q9ERK0 72388 16|16 C4 mouse T184-p 2926100 SMDGLFGtIAYLPPE Pkinase enzymatic activity, induced transcription, altered 12676934 1 0 0 WT ANKRD3 and even mutant T184A can activate NFkB. -Cacna1e CACNA1E Channel, calcium; Membrane protein, integral; Membrane protein, multi-pass Q07652 54234 13q21 rat T365-p 455592 LEVLRRAtIKRSRTE activity, induced 15840578 1 0 9 potentiation of Ca(2+) currents -PHB1 PHB Apoptosis; Cell cycle regulation; Chaperone; Mitochondrial; Motility/polarity/chemotaxis; Nuclear receptor co-regulator; Oncoprotein; Transcription, coactivator/corepressor P35232 5245 17q21.33 human S121-gl 6374003 YDERVLPsITTEILK Band_7 phosphorylation 19238206 1 0 0 -PITPNM1 PITPNM1 Cell surface O00562 9600 11q13.2 human T794-p 451456 LEMLVPStPTSTSGA DDHD molecular association, regulation PLK1(INDUCES) 15125835 1 1 0 -NBN NBS1 Cell cycle regulation; DNA repair, damage O60934 4683 8q21.3 human S343-p 448605 TTPGPSLsQGVSVDE activity, induced; acetylation; phosphorylation cell cycle regulation; carcinogenesis, induced; DNA repair, induced; apoptosis, induced; chromatin organization, altered; cell growth, altered 10802669; 12861053; 14707289; 15733840; 17431132; 17526493; 18003706; 18644472; 24876101; 33568520 46 20 69 -VAV2 VAV2 GEF; GEF, Rac/Rho; Motility/polarity/chemotaxis P52735 7410 9q34.2 human Y142-p 452200 TENDDDVyRSLEELA intracellular localization cell adhesion, induced 24858039 2 7 71 localization to focal adhesions -Cdh2 CDH2 Cell adhesion; Membrane protein, integral; Motility/polarity/chemotaxis P15116 12558 18 A1|18 10.1 cM mouse Y852-p 450692 NDPTAPPyDSLLVFD CADH_Y-type_LIR molecular association, regulation SHC1(INDUCES) 10502299 2 0 0 -SREBF1 SREBP-1 iso3 DNA-binding; Membrane protein, integral; Membrane protein, multi-pass; Transcription factor P36956-3 6720 17p11.2 human T81-p 36533415 SPPQPAPtPLKMYPS transcription, induced 25353341 1 0 0 mRNA expression of central SREBP-1 target genes; Phosphorylation interferes with lipid metabolism and the secretory activity of liver cells. -ZNF322 ZNF322A C2H2-type zinc finger protein; Transcription factor Q6U7Q0 79692 6p22.2 human S396-p 114810401 ELSPPHAsEASQMS_ protein degradation; ubiquitination transcription, inhibited 28581525 1 0 0 -Fos Fos DNA-binding; Motility/polarity/chemotaxis; Oncoprotein; Transcription factor P12841 314322 6q31 rat S362-p 448481 AAAHRKGsSSNEPSS protein stabilization; protein conformation; phosphorylation cell cycle regulation; transcription, altered 12134156; 12629509; 17223854; 8622865 10 3 1 -Pten PTEN Carbohydrate Metabolism - inositol phosphate; EC 3.1.3.16; EC 3.1.3.48; EC 3.1.3.67; Motility/polarity/chemotaxis; Nuclear receptor co-regulator; PHOSPHATASE; Phosphatase, lipid; Tumor suppressor O08586 19211 19 C1|19 28.14 cM mouse S380-p 448313 EPDHYRYsDTTDSDP enzymatic activity, inhibited; intracellular localization cell cycle regulation 18332125; 24367090 40 0 0 -NF1 NF1 iso2 GAP; GAP, Ras; Motility/polarity/chemotaxis; Nucleolus; Tumor suppressor P21359-2 4763 17q11.2 human S2813-p 456018 AGSFKRNsIKKIV__ molecular association, regulation; activity, inhibited 14-3-3 beta(INDUCES) 14741381 1 1 12 -NR3C1 GR DNA-binding; Mitochondrial; Nuclear receptor; Transcription factor P04150 2908 5q31.3 human S203-p 447967 DLEFSSGsPGKETNE GCR molecular association, regulation; intracellular localization; activity, inhibited; phosphorylation transcription, induced; transcription, inhibited GRIP1(INDUCES) 17440046; 20047289; 24024586; 25847991 20 7 0 inhibits phosphorylation at site S211 -FBXL21P FBXL21 UBIQUITIN LIGASE; Ubiquitin ligase Q9UKT6 26223 5q31.1 human T33-p 1870414702 FYSSLNQtHTHTVLL protein degradation; molecular association, regulation; ubiquitination CUL1(INDUCES) 32937135 2 0 0 induces telethonin ubiquitination and degradation -Sox2 SOX2 Cell development/differentiation; DNA-binding; Transcription factor P48432 20674 3 A3|3 16.93 cM mouse K123-ub 49199202 RKTKTLMkKDKYTLP SOXp protein degradation cell differentiation, inhibited; transcription, inhibited 26292759 1 1 0 -APLNR APLNR GPCR, family 1; Membrane protein, integral; Membrane protein, multi-pass; Receptor, GPCR P35414 187 11q12.1 human S335-p 1870435802 QSRCAGTsHSSSGEK molecular association, regulation ARRB1(INDUCES); ARRB2(INDUCES) 32863206 1 1 0 BRET assay used for interaction -Esrp2 RBM35B RNA-binding Q8K0G8 77411 8|8 D3 mouse K530-ub 52473104 AAAQRCHkKMMKERY RRM_1 carcinogenesis, inhibited; RNA splicing, induced; cell growth, inhibited 26522722 1 0 0 -AKR1C1 AKR1C1 EC 1.1.1.112; EC 1.1.1.149; EC 1.3.1.20; Oxidoreductase; Xenobiotic Metabolism - metabolism by cytochrome P450 Q04828 1645 10p15.1 human K201-ub 12390205 HPYFNQRkLLDFCKS Aldo_ket_red molecular association, regulation carcinogenesis, induced; cell motility, induced; transcription, induced STAT3(INDUCES) 32104503 1 2 2 pro-metastatic, induces transcription of metastasis-related target genes (SOX2 and TWIST) -ITGB4 ITGB4 iso2 Cell adhesion; Membrane protein, integral; Motility/polarity/chemotaxis; Receptor, misc. P16144-2 3691 17q25.1 human Y1526-p 450142 DLLPNHSyVFRVRAQ fn3 molecular association, regulation cell adhesion, altered SHC1(INDUCES) 11044453 1 2 6 -Mov10 MOV10 EC 3.6.4.13; Helicase; RNA processing; RNA-binding; Spliceosome P23249 17454 3|3 F2.2 mouse S970-p 469850 LQGLSKLsPSTSGPR protein conformation RNA stability, inhibited 36871759 0 28 0 -KIF2C KIF2C Cancer Testis Antigen (CTA); Microtubule-binding; Motility/polarity/chemotaxis; Motor Q99661 11004 1p34.1 human S633-p 5779213 ELSSQMSsFNEAMTQ enzymatic activity, induced cell cycle regulation; cytoskeletal reorganization 25504441 1 5 3 1) Regulates catalytic activity of KIF2C 2) Activates KIF2C during mitosis. 3) Phosphorylation is required for microtubule depolymerization and proper spindle assembly. 4) Prevention of S632/S633 phosphorylation leads to chromosome segregation defects in anaphase. -Twist1 TWIST1 Cell development/differentiation; DNA-binding; Inhibitor; Transcription regulation P26687 22160 12 A3|12 14.81 cM mouse R34-me 40709501 QQPASGKrGARKRRS cell motility, induced 25847239 1 0 0 E-cadherin repression, cell migration and invasion -Ffar4 GPR120 GPCR, family 1; Lipid-binding; Membrane protein, integral; Membrane protein, multi-pass; Receptor, GPCR Q7TMA4 107221 19|19 C2 mouse T349-p 33638004 KGAIFTDtSVRRNDL receptor internalization, induced; molecular association, regulation ARR3(INDUCES) 26873857 2 1 0 -Rab3ip RAB3IP GEF; GEF, Rab Q62739 29885 7q22 rat S247-p 2023489 KTLVLSSsPTSPTQE Sec2p activity, induced; molecular association, regulation; protein conformation; enzymatic activity, induced exocytosis, induced RAB11A(DISRUPTS); RAB8A(INDUCES) 25535387 1 5 1 induces GEF activity of RAB3IP, induces RAB8 activity -AXIN1 axin 1 Adaptor/scaffold; Tumor suppressor O15169 8312 16p13.3 human S217-p 3174923 YTRTGSEsPKVCSDQ transcription, inhibited GSK3B(INDUCES) 17318175 1 5 0 -Cebpa C/EBP-alpha DNA-binding; Transcription factor P05554 24252 1q21 rat T222-p 449824 HLQPGHPtPPPTPVP activity, inhibited transcription, altered 16600022 8 0 0 In 3T3L1 preadipocytes, mutation of T222/T226 to alanines increased transcription at CBE-containing promoter (as compared to WT C/EBP-alpha). S230A had a similar effect as the double T->A mutation. The triple alanine mutation had the highest transcription of the reporter gene. S230A did not reduce T222/226 phosphorylation (although CHIR99021 inhibitor did). -Arhgap12 ARHGAP12 GAP; GAP, Rac/Rho Q8C0D4 75415 18|18 A1 mouse Y241-p 451932 GRPDSPVyANLQELK SH3-WW_linker cell cycle regulation; cell motility, altered 18515860 0 31 753 -TJP1 ZO1 Adaptor/scaffold; Motility/polarity/chemotaxis Q07157 7082 15q13.1 human T772-p 3653898 NHHLFTTtINLNSMN Guanylate_kin molecular association, regulation cell adhesion, inhibited occludin(DISRUPTS) 24338688 1 1 0 15(S)-HETE or 12(S)-HETE (high fat diet) -induced endothelial tight junction (TJ) disruption -F3 F3 Cell surface; Membrane protein, integral P13726 2152 1p21.3 human S295-p 3540201 ENSPLNVs_______ cell motility, altered 15630487 1 0 0 -MAPKAP1 Sin1 Adaptor/scaffold Q9BPZ7 79109 9q33.3 human S343-p 1876127002 DLDSTLEsQSAWEFC molecular association, regulation; phosphorylation apoptosis, inhibited ECT2(INDUCES) 34982576 1 1 0 induces AKT phosphorylation -SNAI1 Snail1 C2H2-type zinc finger protein; Transcription factor O95863 6615 20q13.13 human S104-p 455881 GKGSQPPsPPSPAPS activity, induced; protein degradation; protein stabilization; ubiquitination; intracellular localization carcinogenesis, induced; cell motility, induced; transcription, altered 15647282; 19923321; 20305697; 23644467 6 0 0 -Mapk7 ERK5 EC 2.7.11.24; KINASE; Kinase, protein; Protein kinase, CMGC; Protein kinase, Ser/Thr (non-receptor) Q9WVS8 23939 11|11 B2 mouse S496-p 455518 SRLRDGPsAPLEAPE sumoylation cell cycle regulation; endocytosis, altered; carcinogenesis, altered; cell motility, induced; apoptosis, induced; transcription, induced; transcription, inhibited 23243209; 29594152; 30586719; 37264926; 37307577 10 2 0 endothelial inflammation; alters phagocytosis; decreasesd eNOS expression and increased VCAM-1 expression; inflamation; induces NRF2 sumoylation -WAS WASP Adaptor/scaffold; Motility/polarity/chemotaxis P42768 7454 Xp11.23 human S483-p 449294 KRSRAIHsSDEGEDQ molecular association, regulation cytoskeletal reorganization ARPC3(INDUCES) 12769847 2 10 0 The double mutant (S483A/S484A) was used in this study. -Irs1 IRS1 Adaptor/scaffold; Motility/polarity/chemotaxis P35570 25467 9q34 rat S632-p 447506 NGDYMPMsPKSVSAP molecular association, regulation; enzymatic activity, inhibited PIK3R2(DISRUPTS); PIK3R1(DISRUPTS) 16354680; 8626671 41 26 1 -PHKB PHKB KINASE; Protein kinase, regulatory subunit P12798 100009137 rabbit S12-p 470137 TGLMAEVsWKVLERR molecular association, regulation; enzymatic activity, inhibited PHKG1(INDUCES) 17123541 2 0 0 -LMNA lamin A/C Cytoskeletal P02545 4000 1q22 human S404-p 478681 RSRGRASsHSSQTQG protein degradation; molecular association, regulation; intracellular localization cell cycle regulation; transcription, inhibited 14-3-3 beta(INDUCES) 23430973; 7925482 8 49 106 -RBL2 Rb-like 2 Transcription, coactivator/corepressor; Tumor suppressor Q08999 5934 16q12.2 human T1097-p 449742 SMIRTGEtPTKKRGI molecular association, regulation; intracellular localization cell cycle regulation KPNA1(DISRUPTS); E2F4(DISRUPTS) 11157749; 20857408 3 1 0 -BRCA1 BRCA1 EC 6.3.2.-; Nuclear receptor co-regulator; Transcription, coactivator/corepressor; Tumor suppressor; UBIQUITIN LIGASE; Ubiquitin conjugating system; Ubiquitin ligase P38398 672 17q21.31 human T509-p 448039 LKRKRRPtSGLHPED intracellular localization transcription, induced 17428466 3 6 73 -TRPV1 TRPV1 Channel, cation; Membrane protein, integral; Membrane protein, multi-pass; Receptor, misc. Q8NER1 7442 17p13.2 human T705-p 487542 WKLQRAItILDTEKS activity, induced 24920628 6 0 0 TRPV1 internalization, sensitivity to capsaicin, heat sensitivity -Slc6a5 SLC6A5 Membrane protein, integral; Membrane protein, multi-pass; Transporter; Transporter, SLC family P58295 171148 1q22 rat K751-ub 27209758 GRFIERLkLVCSPQP protein degradation; ubiquitination; intracellular localization endocytosis, induced; transcription, altered 23484054; 31628376 2 1 0 LNX2 mediated degradation was slower and seen after 48 hours, PKC regulation of SLC6A5 activity, modulation in the glycine transport activity of SLC6A5 -TERF2 TRF2 DNA repair, damage; DNA-binding Q15554 7014 16q22.1 human R63-me 10338220 AAGRRASrSSGRARR cell cycle regulation; cell growth, altered 19596784 1 0 0 -Syn1 SYN1 Vesicle O88935 20964 X A1.3|X 16.37 cM mouse Y301-p 478277 VVALTKTyATAEPFI Synapsin_C exocytosis, altered 20530578 2 0 2 -Smpd3 SMPD3 EC 3.1.4.12; Lipid Metabolism - sphingolipid; Membrane protein, integral; Phospholipase Q9JJY3 58994 8|8 D3 mouse K103-ub 1880099300 SYSRLEDkNPAGGAA protein degradation 36261549 1 0 0 -RPIA RPIA Carbohydrate Metabolism - pentose phosphate pathway; EC 5.3.1.6; Isomerase P49247 22934 2p11.2 human R42-m1 12195687 DLPGSHVrLPGRAQS enzymatic activity, induced carcinogenesis, induced; cell growth, induced 32157557 1 5 11 -CCDC88A girdin Actin-binding Q3V6T2 55704 2p16.1 human S1417-p 456477 INRERQKsLTLTPTR molecular association, regulation; intracellular localization carcinogenesis, induced; cell motility, induced; cell motility, altered; cell motility, inhibited; cytoskeletal reorganization ACTB(INDUCES) 16139227; 24662825; 30935690 9 18 1 -RAD51 RAD51 DNA repair, damage; Mitochondrial Q06609 5888 15q15.1 human Y315-p 448324 ETRICKIyDSPCLPE Rad51 molecular association, regulation cell cycle regulation; apoptosis, altered RAD51(DISRUPTS) 11684015; 15330855 4 0 1 -DDX1 DDX1 EC 3.6.4.13; Helicase; RNA-binding Q92499 1653 2p24.3 human K234-m1 58123001 LFPACVLkNAELKFN DEAD; SPRY molecular association, regulation L3MBTL iso4(INDUCES) 23583077 0 1 0 -Gabrg2 GABRG2 Channel, chloride; Channel, ligand-gated; Membrane protein, integral; Membrane protein, multi-pass; Transporter; Transporter, ion channel P22723 14406 11 A5|11 24.8 cM mouse K366-ub 11956714 VSNRKPSkDKDKKKK Neur_chan_memb protein degradation; receptor internalization, altered 19815531 1 0 0 regulation of the late endosomal/lysosomal trafficking of GABA receptors, regulation of synaptic transmission -Map2k1 MEK1 EC 2.7.12.2; KINASE; Kinase, protein; Protein kinase, STE; Protein kinase, dual-specificity (non-receptor) Q01986 170851 8q24 rat T292-p 448287 ETPPRPRtPGRPLSS Pkinase enzymatic activity, inhibited 8114697 14 6 0 -KCNQ1 Kv7.1 Channel, potassium; Membrane protein, integral; Membrane protein, multi-pass P51787 3784 11p15.5-p15.4 human S484-p 40556220 PHFMRTNsFAEDLDL KCNQ_channel activity, inhibited 29410121 1 2 0 reduction of currrent density -FOXP3 FOXP3 C2H2-type zinc finger protein; Cell cycle regulation; DNA-binding; Transcription factor Q9BZS1 50943 Xp11.23 human K227-ac 31914102 ADHLLDEkGRAQCLL FOXP-CC protein stabilization 23644046 1 0 0 -HDAC4 HDAC4 DEACETYLASE; Deacetylase; EC 3.5.1.98; Hydrolase; Nuclear receptor co-regulator; SUMO LIGASE P56524 9759 2q37.3 human S246-p 448488 FPLRKTAsEPNLKLR protein degradation; protein stabilization; molecular association, regulation; intracellular localization cell cycle regulation; carcinogenesis, induced; apoptosis, inhibited; transcription, induced; transcription, altered 14-3-3 beta(INDUCES); LATS2(DISRUPTS); 14-3-3 epsilon(INDUCES); YAP1(INDUCES) 10869435; 10958686; 16980613; 24904057; 28319066; 35780183 13 24 25 -EPHA2 EphA2 EC 2.7.10.1; KINASE; Kinase, protein; Membrane protein, integral; Protein kinase, TK; Protein kinase, tyrosine (receptor) P29317 1969 1p36.13 human Y930-p 457516 EHFMAAGyTAIEKVV SAM_1 molecular association, regulation; enzymatic activity, induced cell differentiation, altered; cell motility, induced GRB2(INDUCES); NCK1(INDUCES); VAV3(INDUCES); SHIP-2(INDUCES); PIK3R1(INDUCES) 18387945; 23358419; 24825902 3 3 13 -Kcnd2 Kv4.2 Channel, potassium; Membrane protein, integral; Membrane protein, multi-pass Q9Z0V2 16508 6 A2-A3.1|6 8.49 cM mouse T38-p 450461 PRQERKRtQDALIVL activity, induced 31311860 2 0 0 -DAP3 DAP3 Apoptosis; Mitochondrial; Nuclear receptor co-regulator P51398 7818 1q22 human T237-p 2226209 ITRVRNAtDAVGIVL DAP3 apoptosis, induced 18227431 1 0 0 -DLG4 PSD-95 Adaptor/scaffold P78352 1742 17p13.1 human S116-p 1875393402 GRLRVNDsILFVNEV PDZ molecular association, regulation Stargazin(INDUCES); NMDAR2B(INDUCES) Other(DISRUPTS) 34761188 0 1 0 inhibits binding to AVLX-144 -TAB1 TAB1 Activator; Motility/polarity/chemotaxis Q15750 10454 22q13.1 human S423-p 456222 QMVNGAHsASTLDEA activity, inhibited; phosphorylation 15590691; 19393267 6 0 0 inhibits phosphorylation of TAK1; inhibits TAK1 T187 phosphorylation -BCLAF1 BCLAF1 RNA-binding; Transcription factor Q9NYF8 9774 6q23.3 human S290-p 455931 RYSPSQNsPIHHIPS THRAP3_BCLAF1 intracellular localization; phosphorylation carcinogenesis, induced; DNA repair, induced; cell growth, induced; apoptosis, inhibited 34372878 1 80 31 regulates H2AX phosphorylation -MAT2A MAT2A Amino Acid Metabolism - cysteine and methionine; EC 2.5.1.6; Other Amino Acids Metabolism - selenoamino acid; Transferase P31153 4144 2p11.2 human K81-ac 11319857 RAAVDYQkVVREAVK S-AdoMet_synt_N protein degradation; ubiquitination; methylation carcinogenesis, inhibited; cell growth, inhibited 25925782 1 2 0 decreased gobal methylation -SCN5A SCN5A Channel, sodium; Membrane protein, integral; Membrane protein, multi-pass Q14524 6331 3p22.2 human S528-p 451569 KPRSSRGsIFTFRRR Na_trans_cytopl activity, induced 12242273; 24795344 4 2 1 -NR1H4 NR1H4 iso2 DNA-binding; Nuclear receptor Q96RI1-2 9971 12q23.1 human S135-p 4245801 VVCGDRAsGYHYNAL zf-C4 activity, induced; molecular association, regulation transcription, induced PGC-1 alpha(INDUCES) 18755856 1 0 0 -TP73 p73 DNA-binding; Transcription factor; Tumor suppressor O15350 7161 1p36.32 human S471-p 18944909 GEMSSSHsAQSMVSG protein stabilization; molecular association, regulation; intracellular localization carcinogenesis, induced; transcription, inhibited DNA(INDUCES) 21482671 1 0 0 p73 inhibits p53 transcriptional capabilities -Prag1 SGK223 EC 2.7.10.2; KINASE; Kinase, protein; Motility/polarity/chemotaxis; Protein kinase, Other; Protein kinase, Ser/Thr (non-receptor) D3ZMK9 306506 16q12.2 rat Y391-p 449701 AVQPEPIyAESAKRK molecular association, regulation; phosphorylation cytoskeletal reorganization CSK(INDUCES) 21873224 2 33 699 phosphorylation at the priming site of SGK223 decreases phosphorylation of Y530 and increases phosphorylation of Y419 of Src. -Ppp1r1b DARPP-32 Motility/polarity/chemotaxis; Protein phosphatase, regulatory subunit Q60829 19049 11|11 D mouse T34-p 448047 MIRRRRPtPAMLFRV DARPP-32 activity, induced; molecular association, regulation; phosphorylation; enzymatic activity, induced transcription, altered PPP1CA(INDUCES) 10669419; 16123776; 16971527; 17301223; 18496528; 36055413 67 6 44 Mutation of T34 impaired several behavioral responses to repeated cocaine administration, and abolished acute cocaine-regulated gene expression. -PLCG1 PLCG1 Carbohydrate Metabolism - inositol phosphate; EC 3.1.4.11; Motility/polarity/chemotaxis; Phospholipase P19174 5335 20q12 human Y1003-p 3954534 KGKKFLQyNRLQLSR PI-PLC-Y activity, inhibited signaling pathway regulation 12652307 1 1 30 -Bik BIK Apoptosis; Membrane protein, integral; Mitochondrial O70337 12124 15|15 E1 mouse T116-p 25171001 IWSWRVLtPGAWVSP bcl-2I13 ubiquitination 22388352 1 0 0 -HDAC6 HDAC6 DEACETYLASE; Deacetylase; EC 3.5.1.98; Nuclear receptor co-regulator; Ubiquitin conjugating system Q9UBN7 10013 Xp11.23 human S1035-p 29604201 DHQTPPTsPVQGTTP enzymatic activity, induced cell motility, induced 24089523 1 2 0 -Ppp1r9b Spinophilin Adaptor/scaffold; Protein phosphatase, regulatory subunit O35274 84686 10q26 rat S94-p 448728 SDRGVRLsLPRASSL molecular association, regulation; intracellular localization endocytosis, induced ADRA2A(DISRUPTS) 12417592; 18367453; 23965992 7 8 1 -CCDC88A girdin Actin-binding Q3V6T2 55704 2p16.1 human S1675-p 454193 HHKIKTGsPGSEVVT activity, induced; molecular association, regulation cell motility, induced G-alpha(s)(INDUCES); G-alpha i3(INDUCES); G-alpha i1(INDUCES) 26286990; 27621449; 27864364; 31363053 4 22 0 -Nos3 eNOS Amino Acid Metabolism - arginine and proline; EC 1.14.13.39; Oxidoreductase P70313 18127 5 A3|5 11.32 cM mouse S1176-p 447884 TSRIRTQsFSLQERQ molecular association, regulation; enzymatic activity, induced signaling pathway regulation CTNNB1(INDUCES) 16081872; 21540184; 22042868; 33770326; 34222255; 35017029; 35331293 217 18 7 BVR S-nitrosylation -EHMT2 EHMT2 Amino Acid Metabolism - lysine degradation; EC 2.1.1.43; METHYLTRANSFERASE; Methyltransferase; Methyltransferase, protein lysine Q96KQ7 10919 6p21.33 human T555-p 3827109 IPRGDGVtPPAGTAA transcription, inhibited 32611815 1 20 8 -FADD FADD Adaptor/scaffold; Apoptosis Q13158 8772 11q13.3 human K120-sm 62489903 RRLARQLkVSDTKID Death molecular association, regulation; intracellular localization CASP10(INDUCES); DRP1(INDUCES) 27799292 1 0 0 -PPP2R5B PPP2R5B Motility/polarity/chemotaxis; Protein phosphatase, regulatory subunit Q15173 5526 11q13.1 human S368-p 2655004 QVARCVSsPHFQVAE B56 phosphorylation 17200115 1 0 0 AKT phosphorylation -NHE-3 NHE3 Membrane protein, integral; Membrane protein, multi-pass; Transporter; Transporter, SLC family P26432 100009430 rabbit S607-p 450900 SLEQRRRsVRDAEDV intracellular localization; activity, inhibited 25480791 13 1 0 decreased surface expression of NHE3, phosphorylation of this site with other 2 sites are together necessary for activity inhibition -PAK1 PAK1 EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, STE; Protein kinase, Ser/Thr (non-receptor) Q13153 5058 11q13.5-q14.1 human T212-p 448176 VIEPLPVtPTRDVAT carcinogenesis, induced; cell growth, induced 31660987 17 27 19 Inhibitors decreased the tumor growth by inhibiting the phosphorylation -CCDC50 CCDC50 Inhibitor Q8IVM0 152137 3q28 human Y304-p 6377636 SSHKGFHyKH_____ phosphorylation apoptosis, inhibited; cell growth, altered 19059208 1 0 0 ; inhibits NF-kB activity; inhibits phosphorylation of IKKbeta through TNFalpha -Cldn6 Claudin-6 Cell adhesion; Membrane protein, integral; Membrane protein, multi-pass Q9Z262 54419 17|17 A3.3 mouse Y200-p 7792487 PRHYMACySTSVPHS cell adhesion, altered; signaling pathway regulation 31740618 1 2 17 -Vim Vimentin Cytoskeletal; Motility/polarity/chemotaxis P20152 22352 2 A1|2 10.04 cM mouse Y117-p 450350 LNDRFANyIDKVRFL Filament cytoskeletal reorganization 30696956 4 27 649 -CCNB1 CCNB1 Activator; Cell cycle regulation P14635 891 5q13.2 human K36-ub 603484742 TAPAATSkPGLRPRT protein degradation cell cycle regulation 12198152 1 2 0 -Il13ra1 IL13R Membrane protein, integral; Receptor, cytokine O09030 16164 X A3.3|X 20.49 cM mouse Y402-p 450931 HWKKYDIyEKQSKEE molecular association, regulation STAT3(INDUCES) 10409622 1 0 15 Ligand-induced phosphorylation of IL13R slightly increases its association with STAT3; results in tyrosine phosphorylation of STAT3. -Jdp2 JDP2 Nuclear receptor co-regulator; Transcription, coactivator/corepressor P97875 81703 12|12 D2 mouse T148-p 448312 VRTDSVRtPESEGNP protein degradation 21463260 3 11 5 -PI4K2A PI4K2A EC 2.7.1.67; Kinase, lipid; Motility/polarity/chemotaxis Q9BTU6 55361 10q24.2 human S47-p 468434 AAAGSGPsPPGSPGH molecular association, regulation endocytosis, inhibited BRSK1(INDUCES); VACAMKL(INDUCES); TRIM3(INDUCES); CENTG1(INDUCES) 37314927 2 73 6 -NEDD9 Cas-L Adaptor/scaffold; Motility/polarity/chemotaxis Q14511 4739 6p24.2 human Y189-p 448895 SHTTQGVyDIPPSSA cell motility, inhibited; cell adhesion, altered 23874939 1 10 111 Y189D may have reduced dynamics in comparison to WT. -SERPINA1 SERPINA1 Inhibitor; Secreted; Secreted, signal peptide P01009 5265 14q32.13 human T416-p 469611 MGKVVNPtQK_____ cell growth, altered 15498560 1 0 0 Phosphorylated C26 peptide did not induce cell increased proliferation and mitogenic action was increased 2 fold compared to unphosphorylated C26. -ITGB4 ITGB4 Cell adhesion; Membrane protein, integral; Motility/polarity/chemotaxis; Receptor, misc. P16144 3691 17q25.1 human Y1510-p 450141 STTLPRDySTLTSVS molecular association, regulation; phosphorylation carcinogenesis, induced; cell motility, induced; signaling pathway regulation Syk(INDUCES) 25531330; 31242404 6 11 166 induces expression of ITGB4 and ERK1/2, induces phosphorylation of MEK1 and ERK1/2, MEK1-ERK1/2 signaling pathway -LMTK2 Lmr2 EC 2.7.11.1; KINASE; Kinase, protein; Membrane protein, integral; Membrane protein, multi-pass; Protein kinase, Ser/Thr (non-receptor); Protein kinase, TK; Protein kinase, tyrosine (receptor) Q8IWU2 22853 7q21.3 human S1450-p 4957483 LQTSKYFsPPPPARS enzymatic activity, induced 22220831 1 12 9 -Wnk4 WNK4 EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, Other; Protein kinase, Ser/Thr (non-receptor) Q80UE6 69847 11|11 D mouse K451-ub 40323310 DGEKPGLkLWLRMED OSR1_C protein degradation 23576762 1 1 0 regulates electrolyte homeostasis and involved in Pseudohypoaldosteronism type II (PHAII) pathogenesis -Klf4 KLF4 C2H2-type zinc finger protein; DNA-binding; Transcription factor Q923V7 114505 5q24 rat T400-p 22996305 RKRTATHtCDYAGCG zf-C2H2 molecular association, regulation transcription, inhibited SP1(DISRUPTS) 22282354 1 0 0 -HSF1 HSF1 DNA-binding; Transcription factor Q00613 3297 8q24.3 human S363-p 455486 DTEGRPPsPPPTSTP Vert_HS_TF transcription, inhibited 25963659 6 34 42 under non-stressed conditions, upon heat shock S to A mutant showed 60% higher luciferase activity -Pxn PXN Adaptor/scaffold; Cell adhesion; Cytoskeletal; Motility/polarity/chemotaxis Q66H76 360820 12q16 rat S83-p 451113 YAHQQPPsPSPIYSS Paxillin cell adhesion, altered 14970194 7 40 44 -TNKS TNKS EC 2.4.2.30; Transferase O95271 8658 8p23.1 human S978-p 471333 VVSASLIsPASTPSC protein stabilization; intracellular localization; enzymatic activity, induced cell cycle regulation; cell growth, induced 21818122 2 0 0 -Mdm2 MDM2 EC 6.3.2.-; EC 6.3.2.19; Inhibitor; Ligase; NEDDYLATION LIGASE; Neddylation Ligase; Nucleolus; Oncoprotein; UBIQUITIN LIGASE; Ubiquitin conjugating system; Ubiquitin ligase P23804 17246 10 D2|10 66.32 cM mouse S394-p 447898 SQESDDYsQPSTSSS protein degradation; molecular association, regulation; phosphorylation cell growth, inhibited; transcription, induced p53(DISRUPTS) 27568562 15 2 0 strongly suppresses Myc oncogene-induced tumorigenesis ; S394 phosphorylation increased p53 activation (S15 phosphorylation) -H1-4 H1E DNA-binding P10412 3008 6p22.2 human K34-ac 3925584 SAGAAKRkASGPPVS molecular association, regulation chromatin organization, altered; transcription, induced TAF1(INDUCES) 22465951 1 1 1 -PAK5 PAK5 EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, STE; Protein kinase, Ser/Thr (non-receptor) Q9P286 57144 20p12.2 human S99-p 29574070 ISVTRSNsLRKESPP intracellular localization cell motility, induced 35969127 1 1 0 -SNX27 SNX27 Vesicle Q96L92 81609 1q21.3 human S51-p 486072 VRIVKSEsGYGFNVR PDZ receptor recycling, inhibited; molecular association, regulation; protein conformation PTHR(DISRUPTS); DGKZ(DISRUPTS); SEMA4C(DISRUPTS) 33605979 1 26 0 inhibits endocytic trafficking -STIM1 STIM1 Calcium-binding; Endoplasmic reticulum; Membrane protein, integral Q13586 6786 11p15.4 human T389-p 37049500 KIKKKRNtLFGTFHV SOAR activity, induced; protein conformation 25504574; 29326165 2 0 0 1) ARC channel activation 2) CRAC channel inhibition; induce an extension of the C-terminal helical region of the CC2 region of STIM1 and enables the selective activation of the ARC channels -ATP7B ATP7B EC 3.6.3.54; Hydrolase; Membrane protein, integral; Membrane protein, multi-pass; Transporter; Transporter, ion channel; Vesicle P35670 540 13q14.3 human S340-p 25786200 GSGTDHRsSSSHSPG intracellular localization; protein conformation 22898812 1 0 0 mutant does not return to TGN in response to copper depletion; S340/341A mutant shifts ATP7B from trans-Golgi Network (TGN) to vesicles -JAK2 JAK2 EC 2.7.10.2; KINASE; Kinase, protein; Oncoprotein; Protein kinase, TK; Protein kinase, tyrosine (non-receptor) O60674 3717 9p24.1 human Y221-p 451493 IRAKIQDyHILTRKR FERM_F2 enzymatic activity, induced carcinogenesis, induced; transcription, induced; signaling pathway regulation 34031055 14 5 1 CD44/JAK2/STAT2/CDA signaling pathway -STXBP5L STXBP5L Q9Y2K9 9515 3q13.33 human S772-p 34668138 SSGKRLSsADVSKVN protein degradation 25002582 1 1 0 ; in a multiple residue S->D mutant -CSNK1E CK1E EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, CK1; Protein kinase, Ser/Thr (non-receptor) P49674 1454 22q13.1 human T407-p 453420 SRIPASQtSVPFDHL enzymatic activity, inhibited 10542239; 12223474 2 6 1 some subset of these 8 sites -Csf1r CSFR EC 2.7.10.1; KINASE; Kinase, protein; Membrane protein, integral; Oncoprotein; Protein kinase, TK; Protein kinase, tyrosine (receptor) P09581 12978 18 E1|18 34.41 cM mouse Y974-p 455527 PLLQPNNyQFC____ molecular association, regulation cell differentiation, altered; cytoskeletal reorganization CBL(INDUCES) 11850825; 18519746 2 0 0 -Dusp4 DUSP4 EC 3.1.3.16; EC 3.1.3.48; PHOSPHATASE; Protein phosphatase, dual-specificity Q8BFV3 319520 8|8 A4 mouse T361-p 25123903 LRERGKAtPTPTSQF protein stabilization 22430215 1 0 0 -SSTR2 SSTR2 GPCR, family 1; Membrane protein, integral; Membrane protein, multi-pass; Receptor, GPCR P30874 6752 17q25.1 human T354-p 7652101 KSRLNETtETQRTLL receptor internalization, induced; receptor desensitization, induced; receptor recycling, induced 24565897; 24637622 9 0 1 -CD8A CD8A Membrane protein, integral P01732 925 2p11.2 human S231-p 25286619 SGDKPSLsARYV___ carcinogenesis, inhibited; signaling pathway regulation 30131370 0 2 1 -GMNN Geminin Cell cycle regulation; Motility/polarity/chemotaxis O75496 51053 6p22.3 human S200-p 475942 TCAEGTVsSSTDAKP apoptosis, altered 17261582 1 0 0 regulates geminin cleavage by caspase-3 -Mos MOS EC 2.7.11.1; KINASE; Kinase, protein; Oncoprotein; Protein kinase, Other; Protein kinase, Ser/Thr (non-receptor) P00536 17451 4 A1|4 2.16 cM mouse S3-p 448658 _____MPsPLSLCRY protein conformation; enzymatic activity, induced 9632642 3 1 0 in vitro -PRICKLE1 PRICKLE1 Unknown function Q96MT3 144165 12q12 human T370-p 55571503 LSGNADDtLSRKLDD molecular association, regulation cell motility, induced; cell growth, induced RICTOR(INDUCES) 27184734 1 0 0 -PXN PXN Adaptor/scaffold; Cell adhesion; Cytoskeletal; Motility/polarity/chemotaxis P49024 395832 chicken Y31-p 448785 FLTEETPySYPTGNH molecular association, regulation cytoskeletal reorganization CDK6(INDUCES); CRK(INDUCES) 10825157; 12949231 49 8 64 -KIR3DL1 KIR3DL1 Membrane protein, integral; Receptor, misc. P43629 3811 19q13.42 human S415-p 990302 QRKITRPsQRPKTPP activity, induced; receptor internalization, altered 17911614 1 0 0 -CD8B CD8B iso4 Membrane protein, integral P10966-4 926 2p11.2 human K215-ub 2884407 KFNIVCLkISGFTTC receptor internalization, induced; protein degradation 18490743 1 0 0 -MAP2K5 MEK5 EC 2.7.12.2; KINASE; Kinase, protein; Protein kinase, STE; Protein kinase, dual-specificity (non-receptor) Q13163 5607 15q23 human S311-p 448621 VSTQLVNsIAKTYVG Pkinase molecular association, regulation; intracellular localization; enzymatic activity, induced ERK5(DISRUPTS) 14583600; 7759517 3 5 0 -UBA52-RPS27A-UBB-UBC ubiquitin Ubiquitin-like modifier P62991 mouse K29-ub 3135200 TIENVKAkIQDKEGI ubiquitin cell cycle regulation; cell growth, inhibited; transcription, inhibited 31135381 18 20 136 USP16 regulates T cell proliferation and cell-cycle entry; Ubiquitination of PPP3CB impairs NFAT recruitment and transcription of NFAT-targeted genes -CASQ1 calsequestrin 1 Calcium-binding; Mitochondrial P07221 100009095 rabbit T381-p 451337 VLEGEINtEDDDDED Calsequestrin molecular association, regulation ASPH(INDUCES) 19230141 3 0 0 increases Ca2+ binding capacity of calsequestrin 1 -ADRA1B ADRA1B GPCR, family 1; Membrane protein, integral; Membrane protein, multi-pass; Receptor, GPCR P18841 101843941 hamster S408-p 451005 RKDSLDDsGSCMSGS receptor desensitization, altered 9353340 1 2 2 -YWHAB 14-3-3 beta Adaptor/scaffold P31946 7529 20q13.12 human K117-ac 466016 NATQPESkVFYLKMK 14-3-3 molecular association, regulation SYNPO(DISRUPTS) 23840712 1 2 26 -Npy1r NPY1R GPCR, family 1; Membrane protein, integral; Membrane protein, multi-pass; Receptor, GPCR P21555 29358 16p14 rat T361-p 455139 MHTDVSKtSLKQASP receptor desensitization, altered; receptor internalization, altered 15576634 1 0 0 may be an artifact of the truncation mutants -Cryaa CRYA1 Chaperone; Heat shock protein P24623 24273 20p12 rat S171-p 452108 FSGPKVQsGLDAGHS HSP20 apoptosis, inhibited 22414529 5 5 0 cytoprotective effect -PDE3A PDE3A EC 3.1.4.17; Membrane protein, integral; Membrane protein, multi-pass; Nucleotide Metabolism - purine; Phosphodiesterase Q14432 5139 12p12.2 human S292-p 471415 VFKRRRRsSSVVSAE molecular association, regulation; enzymatic activity, induced SERCA2(INDUCES); AKAP7(NOT_REPORTED) 25593322 2 2 9 -Nfe2l2 NRF2 DNA-binding; Transcription factor Q60795 18024 2 C3|2 44.75 cM mouse Y568-p 460703 RDEDGKPySPSEYSL protein degradation; molecular association, regulation; ubiquitination; intracellular localization Exportin-1(INDUCES) 16513647; 17403689 6 1 1 nuclear export; required for nuclear export of Nrf2 -EPHA3 EphA3 EC 2.7.10.1; KINASE; Kinase, protein; Membrane protein, integral; Protein kinase, TK; Protein kinase, tyrosine (receptor) P29320 2042 3p11.1 human Y779-p 448910 EDDPEAAyTTRGGKI PK_Tyr_Ser-Thr molecular association, regulation; enzymatic activity, induced cytoskeletal reorganization; cell adhesion, altered CRK(INDUCES) 11870224 3 33 700 -TSC2 TSC2 Cell cycle regulation; GAP; GAP, misc.; Nuclear receptor co-regulator; Tumor suppressor P49815 7249 16p13.3 human S939-p 448501 SFRARSTsLNERPKS molecular association, regulation; intracellular localization; activity, inhibited; phosphorylation apoptosis, inhibited; signaling pathway regulation; transcription, altered 14-3-3 beta(INDUCES); 14-3-3 zeta(INDUCES); 14-3-3 epsilon(INDUCES); 14-3-3 gamma(INDUCES) 12438239; 15342917; 16636147; 16702951; 20169078; 27451907; 30684133 25 34 50 mTORC1 activation and signaling -RELA NFkB-p65 DNA-binding; Nuclear receptor co-regulator; Transcription factor Q04206 5970 11q13.1 human T505-p 455490 EAITRLVtGAQRPPD cell growth, inhibited; apoptosis, inhibited; cytoskeletal reorganization; cell motility, inhibited; transcription, altered; transcription, inhibited 15775976; 21737676 4 0 0 induces NOXA gene expression -Tpt1 TPT1 Calcium-binding; Microtubule-binding P63029 116646 15q11 rat S15-p 40584902 ISHDELFsDIYKIRE TCTP intracellular localization 25854427 1 1 0 -EPOR EPOR Membrane protein, integral; Receptor, cytokine P19235 2057 19p13.2 human Y309-p 3133300 GNFQLWLyQNDGCLW phosphorylation cell growth, altered 15878737 1 0 0 -KIT Kit EC 2.7.10.1; KINASE; Kinase, protein; Membrane protein, integral; Oncoprotein; Protein kinase, TK; Protein kinase, tyrosine (receptor) P10721 3815 4q12 human Y570-p 448015 INGNNYVyIDPTQLP activity, induced; molecular association, regulation; enzymatic activity, induced cell growth, altered CTK(INDUCES); SHP-1(INDUCES) 20147452; 21887372; 9038210; 9528781 9 3 12 -TP73 p73 DNA-binding; Transcription factor; Tumor suppressor O15350 7161 1p36.32 human K327-ac 460606 AKNGAASkRAFKQSP molecular association, regulation cell growth, inhibited; apoptosis, induced; transcription, induced DNA(INDUCES) 11804596 1 1 0 induces binding to p53AIP1 gene and induces its transcription, but retains an intact ability to regulate genes. -FOXM1 FOXM1 DNA-binding; Transcription factor Q08050 2305 12p13.33 human K63-ac 57807004 CKFPAGIkIINHPTM activity, induced; protein stabilization; molecular association, regulation; phosphorylation carcinogenesis, induced; cell growth, induced; transcription, induced DNA(NOT_REPORTED) 27542221 1 1 0 -SGO1 SGO1 Cell cycle regulation Q5FBB7 151648 3p24.3 human T346-p 15406076 LEEGVHLtPFRQKVS molecular association, regulation; intracellular localization cell cycle regulation PPP2CA(INDUCES); STAG1(INDUCES); STAG2(INDUCES) 23242214; 24055156 2 4 6 -Ptk2 FAK EC 2.7.10.2; KINASE; Kinase, protein; Protein kinase, TK; Protein kinase, tyrosine (non-receptor) P34152 14083 15 D3|15 33.94 cM mouse S732-p 450196 SSEGFYPsPQHMVQT intracellular localization cytoskeletal reorganization 12941275 5 1 0 Expression of GFP-FAK-S732A mutant results in altered neuronal positioning, abnormal nuclear morphology, and altered nuclear movement in cultured neurons. -ZRANB1 ZRANB1 DEUBIQUITINASE; EC 3.4.19.12; Ligase; Protease; Ubiquitin conjugating system; Ubiquitin-specific protease Q9UGI0 54764 10q26.13 human T35-p 50840530 RAQRPSGtIITEDPF activity, induced signaling pathway regulation 30686098 1 2 0 -Gria1 GluR1 Channel, calcium; Channel, ligand-gated; Membrane protein, integral; Membrane protein, multi-pass P19490 50592 10q22 rat K837-ac 206219719 YKSRSESkRMKGFCL protein stabilization; ubiquitination; receptor internalization, inhibited neural plasticity 28793258 1 0 0 inhibits ubiquitination; impaired learning and memory -FPR1 FPR1 GPCR, family 1; Membrane protein, integral; Membrane protein, multi-pass; Motility/polarity/chemotaxis; Receptor, GPCR P21462 2357 19q13.41 human T331-p 450666 LTEDSTQtSDTATNS receptor desensitization, altered; receptor internalization, altered 10514456 2 1 0 -PAK4 PAK4 EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, STE; Protein kinase, Ser/Thr (non-receptor) O96013 10298 19q13.2 human S474-p 448023 KEVPRRKsLVGTPYW Pkinase intracellular localization; enzymatic activity, induced carcinogenesis, induced; cell growth, altered 11668177; 20926745; 29849120; 35969127 13 66 140 -Ezh2 EZH2 EC 2.1.1.43; METHYLTRANSFERASE; Methyltransferase; Methyltransferase, protein lysine Q61188 14056 6 B2.3|6 22.92 cM mouse T367-p 466987 NNSSRPStPTISVLE protein stabilization; molecular association, regulation; methylation; intracellular localization; protein conformation carcinogenesis, induced; cell growth, induced; transcription, altered SUZ12(INDUCES); EED(INDUCES) 37069142 5 21 45 induces H3 methylation -CCP110 CP110 Cell cycle regulation O43303 9738 16p12.3 human S516-p 23095734 ASSQCIAsPNFGTVS intracellular localization cell cycle regulation 12361598 1 3 1 -Tlr4 TLR4 Membrane protein, integral; Receptor, misc. Q9QUK6 21898 4 C1|4 34.66 cM mouse Y749-p 1881596602 SRWCIFEyEIAQTWQ protein stabilization transcription, induced 37058370 1 1 0 -PASK PASK EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, CAMK; Protein kinase, Ser/Thr (non-receptor) Q96RG2 23178 2q37.3 human T307-p 1868450201 VGRARDGtTFPLSLK phosphorylation; enzymatic activity, induced cell differentiation, induced; signaling pathway regulation 31072927 1 0 0 mTORC1 signaling for muscle cell differentiation, Wdr5 phosphorylation -Akt1 Akt1 EC 2.7.11.1; KINASE; Kinase, protein; Oncoprotein; Protein kinase, AGC; Protein kinase, Ser/Thr (non-receptor) P31750 11651 12 F1|12 61.2 cM mouse S122-p 3189784 EETMDFRsGSPSDNS carcinogenesis, induced; signaling pathway regulation 32473126 0 15 0 FAK-p-HGFR-p-Akt-p-p65-CCL2 FAK-p-HGFR-p-Akt-p-p65-CCL2 -NEDD1 NEDD1 Cell cycle regulation Q8NHV4 121441 12q23.1 human S565-p 25533008 SVTAGVAsSLSEKIA molecular association, regulation cytoskeletal reorganization TUBG1(INDUCES) 22595525 1 1 0 Promote NEDD1 activity; regulates spindle assembly in mitosis -HIF1A HIF1A Autophagy; DNA-binding; Transcription factor Q16665 3091 14q23.2 human S668-p 11073382 DTQSRTAsPNRAGKG protein stabilization cell motility, induced; cell growth, induced 24189531 1 1 1 enhances invasion, angiogenesis, and tumor growth -Flot2 FLOT2 Cell adhesion Q9Z2S9 83764 10q25 rat Y27-p 1270905 CGSDYKQyVFGGWAW Band_7 intracellular localization cell motility, altered; cytoskeletal reorganization 17213334 1 0 0 -PAGE4 PAGE4 Cancer Testis Antigen (CTA) O60829 9506 Xp11.23 human S9-p 63280101 SARVRSRsRGRGDGQ GAGE protein conformation 28289210 1 1 0 -FGFR1 FGFR1 EC 2.7.10.1; KINASE; Kinase, protein; Membrane protein, integral; Oncoprotein; Protein kinase, TK; Protein kinase, tyrosine (receptor) P11362 2260 8p11.23 human Y154-p 448774 NRMPVAPyWTSPEKM protein degradation; receptor desensitization, altered; receptor internalization, altered cytoskeletal reorganization 10652257; 7516330 4 1 0 -FOXN3 FOXN3 DNA-binding; Transcription factor O00409 1112 14q31.3-q32.11 human S85-p 454694 ESVLRSVsPVQDLDD activity, induced; protein degradation; molecular association, regulation; ubiquitination signaling pathway regulation hnRNP U(DISRUPTS) 36794705 1 14 3 induces NFKB activity and signaling -DDX21 DDX21 EC 3.6.4.13; Helicase; Nucleolus; RNA processing; RNA-binding Q9NR30 9188 10q22.1 human S171-p 452490 SEAASEEsNSEIEQE intracellular localization RNA splicing, inhibited 18703060 1 34 10 -BRD4 BRD4 KINASE; Kinase, protein; Protein kinase, Ser/Thr (non-receptor); Protein kinase, atypical O60885 23476 19p13.12 human R179-m1 57691840 MIVQAKGrGRGRKET carcinogenesis, induced; DNA repair, induced; cell growth, induced; transcription, induced 36475791 1 3 0 -H3c1 H3 DNA-binding P68433 360198 13|13 A3.1 mouse K4-m3 1458621 ____ARTkQTARKST Histone intracellular localization; methylation; phosphorylation; enzymatic activity, induced cell differentiation, inhibited; cell cycle regulation; carcinogenesis, induced; endocytosis, altered; transcription, induced; transcription, altered; cell differentiation, altered; chromatin organization, altered; cell differentiation, induced; cell adhesion, altered; transcription, inhibited 17967893; 18039862; 18728284; 19567879; 19703992; 19779457; 19915707; 20393567; 20574709; 20935159; 22237151; 25519132; 25751424; 26716510; 32341358; 33195484; 33971063; 34608337; 35640597; 35810562 178 10 0 K885A mutant of SETDB1 inhibits enzyme activity but not its localization to target genes, mutant represses some adipogenic genes and inhibits adipocyte differentiation as does WT, but others arenot repressed and don't may not require its enzymatic activity and other H3K9 methyltransferases may be able to compensate. ; H2AK119ub1 at the actively transcribed genes marked by H3K4me3 ; PRC1 mediated repression is achieved by controlling transcriptional burst frequency; DYRK1A inhibition decreases KAT6A and WDR82 phosphorylation and induces H3K27ac and H3K4me3 modi?cation, pharmacological inhibition or genetic deletion of DYRK1A promotes cardiomyocyte cell cycle activation and cardiac repair; axon guidance; modulated during differentiation and epigenitic reprograming -Dusp6 DUSP6 EC 3.1.3.16; EC 3.1.3.48; Motility/polarity/chemotaxis; PHOSPHATASE; Protein phosphatase, dual-specificity Q9DBB1 67603 10|10 D1 mouse S197-p 455266 SATDSDGsPLSNSQP protein degradation signaling pathway regulation 22521266 5 0 0 represses expression of gluconeogenic genes and glucose output -PAWR PAR-4 Apoptosis Q96IZ0 5074 12q21.2 human S231-p 476476 GRYKSTTsVSEEDVS apoptosis, inhibited 24457960 1 15 18 -Ahr AHR DNA-binding; Transcription factor P30561 11622 12 A3|12 15.78 cM mouse S67-p 451013 INKLDKLsVLRLSVS HLH intracellular localization 14985336 1 0 0 -TOB1 TOB1 Adaptor/scaffold; Cell cycle regulation P50616 10140 17q21.33 human S152-p 455535 PASSVSSsPSPPFGH activity, inhibited cell cycle regulation; cell growth, inhibited; cell growth, altered 12050114; 12151396; 22252318 3 0 0 promote mRNA deadenylaion and decay and the ability to suppress proliferation; the antiproliferative activity of TOB1 is inhibited by phosphorylation.; the antiproliferative function of TOB1 is inhibited by phosphorylation. -DDHD1 DDHD1 EC 3.1.1.-; Phospholipase Q8NEL9 80821 14q22.1 human S727-p 465585 TIPSPVTsPVLSRRH DDHD intracellular localization 34089703 2 10 0 -Ahcyl2 AHCYL2 Amino Acid Metabolism - cysteine and methionine; EC 3.3.1.1; Hydrolase; Motility/polarity/chemotaxis; Other Amino Acids Metabolism - selenoamino acid Q68FL4 74340 6|6 A3.3 mouse S160-p 7172003 SSTDSYSsAASYTDS molecular association, regulation SLC4A4(INDUCES) 27382360 2 1 1 S149 and T172 are also involved in activation of SLCA4 -SHC4 SHC4 Adaptor/scaffold Q6S5L8 399694 15q21.1 human Y465-p 462716 DLFDDPCyINTQALQ molecular association, regulation SHP-2(INDUCES) 28213521 1 2 9 -KIF2B KIF2B Microtubule-binding; Motor Q8N4N8 84643 17q22 human S204-p 25247528 HLDSSKIsVLEPPQE activity, induced; intracellular localization cell cycle regulation; cytoskeletal reorganization 22535524 1 1 0 involved in the corrections of k-MT attachment errors in early mitosis, microtubule depolymerization activity -HOXB7 HOXB7 DNA-binding; Motility/polarity/chemotaxis; Transcription factor P09629 3217 17q21.32 human T203-p 465571 NKTAGPGtTGQDRAE cell differentiation, altered 11290787 1 0 0 -Rasgrf1 RASGRF1 GEF; GEF, Ras P27671 19417 9 E3.1|9 47.31 cM mouse S737-p 469604 PLAIGTSsPSRRRKL RasGEF_N protein degradation 16921254 1 2 1 controls nuclear organization in cortical neurons -AR AR DNA-binding; Nuclear receptor; Transcription factor P10275 367 Xq12 human K848-ub 7911900 RIIACKRkNPTSCSR Hormone_recep intracellular localization 35163481 4 1 0 -Bcl2l11 BIM Apoptosis O88498 64547 3q36 rat T110-p 449070 PMSCDKStQTPSPPC apoptosis, induced 12388545 1 1 0 -E2F1 E2F1 DNA-binding; Transcription factor Q01094 1869 20q11.22 human R113-me 57676508 GPARGRGrHPGKGVK protein degradation; molecular association, regulation; ubiquitination; methylation cell cycle regulation; carcinogenesis, induced; cell growth, induced; apoptosis, inhibited; transcription, inhibited TSN(INDUCES) DNA(DISRUPTS) 22327218; 24076217 2 1 0 inhibits asymmetrical methylation. Binding to TSN regulates binding of TSN to DNA -INSIG2 INSIG2 Endoplasmic reticulum; Membrane protein, integral; Membrane protein, multi-pass; Transcription, coactivator/corepressor Q9Y5U4 51141 2q14.1-q14.2 human K100-ub 486341 RHLGEPHkFKREWSS INSIG protein degradation 16549805 1 0 0 INSIG1 is degraded more rapidly than INSIG2 which controlled by serine residues flanking the ubiquitination sites in both proteins. -TOP1 TOP1 EC 5.99.1.2; Isomerase; Nucleolus; Oncoprotein P11387 7150 20q12 human K436-sm 40724401 LNPSSRIkGEKDWQK Topoisom_I molecular association, regulation; enzymatic activity, inhibited POLR2A(INDUCES) 25851487 1 0 0 recruitment of mRNA processing factors to transcriptionally active chromatin preventing R-loops -Ppargc1a PGC-1 alpha Nuclear receptor co-regulator; Transcription, coactivator/corepressor O70343 19017 5|5 C1 mouse S284-p 15422185 KTIERTLsVELSGTA protein stabilization 23201126 1 0 2 -Pxn PXN Adaptor/scaffold; Cell adhesion; Cytoskeletal; Motility/polarity/chemotaxis Q66H76 360820 12q16 rat S130-p 450228 KQKSAEPsPTVMSSS Paxillin intracellular localization 16537926 5 25 4 necessary for formation of NGF-induced neurite extensions -Ermn ERMN Q5RJL0 rat S278-p 3215796 QRIDEFEsMMHL___ Ermin molecular association, regulation; intracellular localization; activity, inhibited cytoskeletal reorganization ACTB(DISRUPTS) 20610382 1 38 27 -EIF6 EIF6 Nucleolus; Translation; Translation initiation P56537 3692 20q11.22 human S243-p 3193267 MRDSLIDsLT_____ intracellular localization translation, altered 32703900 1 15 9 -MAP2K6 MKK6 iso2 EC 2.7.12.2; KINASE; Kinase, protein; Protein kinase, STE; Protein kinase, dual-specificity (non-receptor) P52564-2 5608 17q24.3 human T155-p 448195 LVDSVAKtIDAGCKP Pkinase enzymatic activity, induced 8621675 4 2 2 -PIK3AP1 BCAP Adaptor/scaffold Q9DDT2 374268 chicken Y199-p 450043 CGVQTTVyIIMKCRL DBB molecular association, regulation PIK3R1(INDUCES) 11163197 1 0 0 -MDM2 MDM2 EC 6.3.2.-; EC 6.3.2.19; Inhibitor; Ligase; NEDDYLATION LIGASE; Neddylation Ligase; Nucleolus; Oncoprotein; UBIQUITIN LIGASE; Ubiquitin conjugating system; Ubiquitin ligase Q00987 4193 12q15 human S166-p 448130 SSRRRAIsETEENSD activity, induced; protein degradation; protein stabilization; molecular association, regulation; ubiquitination; intracellular localization; enzymatic activity, induced cell cycle regulation; carcinogenesis, induced; apoptosis, altered; apoptosis, induced; transcription, induced; signaling pathway regulation; translation, altered; cell growth, induced; apoptosis, inhibited; translation, induced p53(INDUCES); p300(INDUCES); ARF1(INDUCES) RNA(INDUCES) 11504915; 11715018; 15024078; 15169778; 15688025; 18467333; 19008219; 20657550; 22525275; 26636645; 27264869; 27617579; 32453417; 34992144; 36149602; 37179400 50 19 5 -Amelx AMELX iso1 Secreted; Secreted, signal peptide P63277-1 11704 X F5|X 78.95 cM mouse S32-p 34729901 SPGYINLsYEVLTPL Amelogenin protein conformation 25071599 4 1 0 -DDX5 DDX5 EC 3.6.4.13; Helicase; Nuclear receptor co-regulator; Nucleolus; RNA splicing; RNA-binding; Spliceosome P17844 1655 17q23.3 human K32-ac 466258 RAGPLSGkKFGNPGE protein stabilization; molecular association, regulation carcinogenesis, induced; transcription, induced HDAC1(INDUCES); HDAC2(INDUCES) 20663877 1 4 84 -Adora3 ADORA3 GPCR, family 1; Membrane protein, integral; Membrane protein, multi-pass; Receptor, GPCR P28647 25370 2q34 rat T307-p 450328 RACRLCQtSDSLDSN receptor desensitization, altered 10692494 1 0 0 -H3c1 H3 DNA-binding P68433 360198 13|13 A3.1 mouse K9-ac 463820 RTKQTARkSTGGKAP Histone protein degradation; molecular association, regulation; acetylation; intracellular localization cell cycle regulation; endocytosis, altered; transcription, induced; transcription, altered; DNA repair, induced; chromatin organization, altered; cell differentiation, induced; cell adhesion, altered; transcription, inhibited p300(INDUCES); PCAF(INDUCES); GCN5(INDUCES) DNA(INDUCES) 10899125; 16687444; 17823087; 18039862; 18243098; 18662547; 18927235; 19109180; 19264835; 19707598; 19859561; 19922872; 19965984; 20067909; 20129940; 20543957; 20561915; 20574709; 20710121; 20935159; 22237151; 23341587; 23405071; 25772242; 32265492; 33087562; 33195484; 34914791 230 26 341 anacarddic acid (AA) and the JNK inhibitor SP600125 inhibit transcription of cardiac hypertrophy-related genes, attenuating cardiomyocyte hypertrophy ; offspring born to mice exposed to human relevant arsenic concentrations ; transcription maintained at normal levels; axon guidance; Histone acetylation induces AKT signaling at AKT promoter; p-JNK directly interacted with HATs inhibiting H3K9ac; modulates circadian rhythms; MYST3 inhibits cellular senescence; SIRT6 inhibits acetylated H3 and AKT signaling -G6PD G6PD Carbohydrate Metabolism - pentose phosphate pathway; Cell development/differentiation; EC 1.1.1.49; Other Amino Acids Metabolism - glutathione; Oxidoreductase P11413 2539 Xq28 human Y322-p 4114824 EGEATKGyLDDPTVP G6PD_C enzymatic activity, induced carcinogenesis, inhibited; cell growth, inhibited 37491277 1 2 5 -TUBGCP6 GCP6 Cytoskeletal; Motility/polarity/chemotaxis Q96RT7 85378 22q13.33 human S1397-p 472628 EDTAAQSsPGRGEEA cytoskeletal reorganization 17182859 1 1 1 role in the attachment of microtubule-organizing centers (MTOC) to IFs in epithelial cells -DLC1 DLC1 GAP; GAP, Rac/Rho; Tumor suppressor Q96QB1 10395 8p22 human S764-p 18260533 SPVTRTRsLSACNKR molecular association, regulation carcinogenesis, altered; cell motility, altered; cell growth, altered 14-3-3 beta(INDUCES); 14-3-3 theta(INDUCES); 14-3-3 eta(INDUCES) 32606003 1 2 0 -RUNX2 AML3 DNA-binding; Transcription factor Q13950 860 6p21.1 human T200-p 27728400 RGKSFTLtITVFTNP Runt molecular association, regulation transcription, induced DNA(INDUCES) 23389849 1 0 0 induction of MMP3 and MMP9 transcription, invasion of breast cancer cells -BRCA1 BRCA1 EC 6.3.2.-; Nuclear receptor co-regulator; Transcription, coactivator/corepressor; Tumor suppressor; UBIQUITIN LIGASE; Ubiquitin conjugating system; Ubiquitin ligase P38398 672 17q21.31 human S632-p 478486 LVVSRNLsPPNCTEL transcription, altered 17334399 1 3 0 inhibits transcription by interfering with DNA-binding ability of BRCA1 -HDAC1 HDAC1 DEACETYLASE; Deacetylase; EC 3.5.1.98; Hydrolase; Nuclear receptor co-regulator Q13547 3065 1p35.2-p35.1 human K438-ac 4219806 RKNSSNFkKAKRVKT enzymatic activity, inhibited transcription, inhibited 16762839 1 0 2 -DTD1 DTD1 DNA replication; EC 3.1.-.-; Hydrolase Q8TEA8 92675 20p11.23 human S204-p 476435 SGAEGDVsSEREP__ molecular association, regulation cell cycle regulation; cell growth, induced MCM7(INDUCES); MCM3(DISRUPTS) 25258324 1 15 0 decreases DTD1 incorporation into HMW, supports DNA replication initiation -Lat LAT Adaptor/scaffold; Membrane protein, integral O54957 16797 7|7 F3 mouse Y235-p 448006 DGEEAPDyENLQELN LAT phosphorylation 15470052 17 3 72 regulates exocytosis and cytokine secretion -Sox11 SOX11 DNA-binding; Transcription factor Q7M6Y2 20666 12|12 A2 mouse S133-p 1290433400 TDPAAKPsAGQSPDK transcription, induced 30385877 1 1 0 regulates neuronal/ dendritic morphogenesis -DVL2 DVL2 Adaptor/scaffold; Motility/polarity/chemotaxis O14641 1856 17p13.1 human T224-p 25538000 MSRFSSStEQSSASR Dishevelled molecular association, regulation; intracellular localization transcription, induced; cytoskeletal reorganization PLK1(INDUCES) 22609948; 32888647 2 1 0 -XRCC1 XRCC1 DNA repair, damage P18887 7515 19q13.31 human S525-p 451451 STDENTDsEEHQEPP molecular association, regulation; intracellular localization PARP1(DISRUPTS); Pnk1(INDUCES) 15066279; 25477519 2 3 3 -Cfl1 Cofilin-1 Cytoskeletal; Motility/polarity/chemotaxis; Nuclear receptor co-regulator P45592 29271 1q43 rat S3-p 448444 _____MAsGVAVSDG intracellular localization; activity, inhibited cell motility, altered; cytoskeletal reorganization 11086013; 11418599; 18171679; 24914207; 34015497; 35809641; 9655397 97 69 3 -Flcn FLCN Tumor suppressor Q76JQ2 303185 10q22 rat S62-p 3206874 SSRVRAHsPAEGAST molecular association, regulation AMPKA1(INDUCES) 19695222; 19914239 5 56 5 -Bdkrb2 BKR2 GPCR, family 1; Membrane protein, integral; Membrane protein, multi-pass; Receptor, GPCR P25023 25245 6q32 rat Y161-p 452084 MLVSIDRyLALVKTM 7tm_1 activity, induced; receptor desensitization, altered 9837936 2 2 0 -Rps6kb1 p70S6K EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, AGC; Protein kinase, Ser/Thr (non-receptor); Translation P67999 83840 10q26 rat T252-p 448606 HDGTVTHtFCGTIEY Pkinase enzymatic activity, induced 7777579; 9632736 36 2 17 -Pdpk1 PDK1 EC 2.7.11.1; KINASE; Kinase, protein; Nuclear receptor co-regulator; Protein kinase, AGC; Protein kinase, Ser/Thr (non-receptor) Q9Z2A0 18607 17|17 A3.3 mouse T516-p 450132 PEAKNFKtFFVHTPN PH_3 enzymatic activity, induced 11877406 5 4 0 -TGFBR2 TGFBR2 EC 2.7.11.30; KINASE; Kinase, protein; Membrane protein, integral; Oncoprotein; Protein kinase, Ser/Thr (receptor); Protein kinase, TKL P37173 7048 3p24.1 human Y336-p 2869603 AKGNLQEyLTRHVIS PK_Tyr_Ser-Thr activity, induced; enzymatic activity, induced; phosphorylation transcription, altered; signaling pathway regulation 24983314; 9169454 3 0 0 -INSR INSR EC 2.7.10.1; KINASE; Kinase, protein; Membrane protein, integral; Protein kinase, TK; Protein kinase, tyrosine (receptor) P06213 3643 19p13.2 human S1064-p 451563 KTVNESAsLRERIEF PK_Tyr_Ser-Thr phosphorylation 10819237 3 1 1 alanine mutations of S1033, S1062, and S1064 increases tyrosine autophosphorylation of InsR -PAK1 PAK1 EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, STE; Protein kinase, Ser/Thr (non-receptor) Q13153 5058 11q13.5-q14.1 human S21-p 448174 APPMRNTsTMIGAGS intracellular localization cytoskeletal reorganization 16490784 3 0 10 No effect on VASP binding. S21A Pak1 mutation effects localization of Pak1 and cell polarization. -Bid BID Apoptosis; Mitochondrial P70444 12122 6 F1|6 57.02 cM mouse S61-p 448404 DELQTDGsQASRSFN BID protein stabilization cell cycle regulation; apoptosis, inhibited 11583622; 16122426 3 0 0 -FANCD2 FANCD2 DNA repair, damage Q9BXW9 2177 3p25.3 human S1401-p 38488713 LQGEEIKsQNSQEST FancD2 activity, induced; molecular association, regulation; ubiquitination; intracellular localization signaling pathway regulation DNA(INDUCES) 37392383 2 4 3 regulates the FA pathway -SLA SLAP Adaptor/scaffold Q13239 6503 8q24.22 human Y120-p 15570321 SETKKGFySLSVRHR SH2 activity, inhibited 24284075 1 0 1 oncogenic c-Kit bypasses the normal cellular negative feedback control -DEPTOR DEPTOR Apoptosis Q8TB45 64798 8q24.12 human S287-p 4723848 SMSSCGSsGYFSSSP protein degradation; molecular association, regulation; ubiquitination carcinogenesis, induced; apoptosis, inhibited; signaling pathway regulation BTRC(INDUCES); mTOR(DISRUPTS); FBW1B(INDUCES) 19446321; 22017876; 22017877 4 3 0 PI3K-Akt signaling -EIF2AK3 PERK EC 2.7.11.1; KINASE; Kinase, protein; Membrane protein, integral; Protein kinase, Other; Protein kinase, Ser/Thr (non-receptor); Translation Q9NZJ5 9451 2p11.2 human Y619-p 1256400 NKVDDCNyAIKRIRL Pkinase enzymatic activity, induced signaling pathway regulation 25113558 4 1 0 STAT3 activation, PERK-JAK1-STAT3 pathway -Porcn PORCN EC 2.3.1.-; Endoplasmic reticulum; Membrane protein, integral; Membrane protein, multi-pass; Transferase Q9JJJ7 53627 X A1.1|X 3.7 cM mouse S378-p 1869465804 ILSACILsKRCLPDC receptor internalization, induced signaling pathway regulation 31611414 1 0 0 -SMAD2 SMAD2 DNA-binding; Transcription factor Q15796 4087 18q21.1 human T8-p 448792 MSSILPFtPPVVKRL activity, induced; protein stabilization; molecular association, regulation transcription, induced SMAD4(INDUCES) 12193595 3 29 0 -CCDC6 CCDC6 Apoptosis; Cytoskeletal; Oncoprotein Q16204 8030 10q21.2 human K74-sm 27992504 QQENKVLkIELETYK DUF2046 intracellular localization transcription, induced; signaling pathway regulation 23145146 1 0 0 cyclic AMP activity -KAT6A MYST3 ACETYLTRANSFERASE; Acetyltransferase; EC 2.3.1.48; Nucleolus; Oncoprotein Q92794 7994 8p11.21 human T369-p 19008950 RGRKRKItLSSQSAS molecular association, regulation; acetylation transcription, inhibited PML(DISRUPTS) 23431171 1 0 0 decreases acetylation -STK11 LKB1 Autophagy; EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, CAMK; Protein kinase, Ser/Thr (non-receptor); Tumor suppressor Q15831 6794 19p13.3 human S428-p 448147 SSKIRRLsACKQQ__ molecular association, regulation; intracellular localization; phosphorylation; enzymatic activity, induced cell cycle regulation; carcinogenesis, induced; carcinogenesis, inhibited; cell motility, induced; signaling pathway regulation; cell growth, altered Exportin-1(INDUCES); STRAD(INDUCES) 16407220; 18321849; 19414597; 34921839; 35835853 33 2 3 -VAV3 VAV3 Actin-binding; Adaptor/scaffold; GEF; GEF, Rac/Rho; Motility/polarity/chemotaxis; Nuclear receptor co-regulator Q9UKW4 10451 1p13.3 human Y160-p 1869344401 VEDEEDLyDCVYGED activity, induced 32561640 1 0 0 VAV3 signaling activity -RPS6KA6 RSK4 EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, AGC; Protein kinase, Ser/Thr (non-receptor) Q9UK32 27330 Xq21.1 human S389-p 457602 HQLFKGFsFVATSIA Pkinase_C enzymatic activity, induced 15632195 1 6 6 -Rps6kb1 p70S6K EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, AGC; Protein kinase, Ser/Thr (non-receptor); Translation Q8BSK8 72508 11|11 C mouse S447-p 448357 GSPRTPVsPVKFSPG molecular association, regulation; enzymatic activity, induced cell differentiation, altered DEDD(INDUCES) 10846175; 19106089 102 54 247 -Tlr9 TLR9 Membrane protein, integral; Receptor, misc. Q9EQU3 81897 9|9 F1 mouse Y870-p 1192504600 RSAQTLPyDAFVVFD TIR protein stabilization; intracellular localization autophagy, inhibited 30024926 1 0 0 regulates receptor maturation -HSP90AA1 HSP90A Chaperone; Heat shock protein P07900 3320 14q32.31 human S726-p 3180213 LEGDDDTsRMEEVD_ protein stabilization; molecular association, regulation carcinogenesis, induced; cell growth, induced HOPX(INDUCES); CHIP(DISRUPTS) 22824801 1 0 0 cell proliferation increased -Smad3 SMAD3 DNA-binding; Nuclear receptor co-regulator; Transcription factor Q8BUN5 17127 9|9 C mouse S213-p 451180 NLSPNPMsPAHNNLD carcinogenesis, inhibited; cell differentiation, induced; transcription, altered 36241625 13 0 0 regulates Th9 differentiation -Xbp1 XBP1 iso2 DNA-binding; Transcription factor O35426-2 22433 mouse K297-sm 13875700 PEFIVSVkKEPLEDD transcription, inhibited 20408817 1 0 0 -HSF2 HSF2 DNA-binding Q03933 3298 6q22.31 human K82-sm 2535908 HIDSGIVkQERDGPV HSF_DNA-bind molecular association, regulation DNA(DISRUPTS) 16428449; 19017645 3 2 0 -DNMT1 DNMT1 Amino Acid Metabolism - cysteine and methionine; Cell development/differentiation; EC 2.1.1.37; METHYLTRANSFERASE; Methyltransferase; Methyltransferase, DNA; Transcription regulation P26358 1786 19p13.2 human K142-m1 17772901 PRTPRRSkSDGEAKP protein degradation; molecular association, regulation; ubiquitination; phosphorylation PHF20L1(INDUCES) 21151116; 21239472; 24492612 4 1 0 -Relb RELB Transcription factor Q04863 19698 7 A3|7 9.93 cM mouse T84-p 1869360403 AAPPPPAtPSWSCTL RelB_leu_zip protein degradation 11781828 1 0 0 -Relb RELB Transcription factor Q04863 19698 7 A3|7 9.93 cM mouse S451-p 36392502 DFFPASIsLPGLEPP RelB_transactiv molecular association, regulation transcription, inhibited IkB-alpha(DISRUPTS) DNA(INDUCES) 30957303 2 0 0 inhibits removal of RelB from cytokine promoters by IkB-alpha -Pebp1 RKIP Lipid-binding; Protein kinase, regulatory subunit P70296 23980 5 F|5 56.88 cM mouse S109-p 59070500 VLSDYVGsGPPSGTG PBP molecular association, regulation TBK1(INDUCES) 28411188 2 0 0 -YTHDF2 YTHDF2 RNA processing; RNA-binding Q9Y5A9 51441 1p35.3 human K571-sm 1881250300 QEEEESVkKERQGRG molecular association, regulation carcinogenesis, induced; transcription, induced RNA(INDUCES) 33577677 1 0 0 increases its binding af?nity of m6 A-modi?ed mRNAs -VIM Vimentin Cytoskeletal; Motility/polarity/chemotaxis P08670 7431 10p13 human K439-sm 1877412900 PLVDTHSkRTLLIKT cell motility, induced; cytoskeletal reorganization; cell growth, altered 32047143 1 1 0 increases its solubility -ATXN10 ataxin-10 Cell development/differentiation Q9UBB4 25814 22q13.31 human T82-p 21514208 ASSLQLItECFRCLR protein degradation; ubiquitination cell cycle regulation 21857149 2 1 0 required for cytokinesis -Stat5a STAT5A DNA-binding; Motility/polarity/chemotaxis; Oncoprotein; Transcription factor P42230 20850 11 D|11 63.77 cM mouse Y694-p 447767 LAKAVDGyVKPQIKQ activity, induced carcinogenesis, induced; carcinogenesis, inhibited; cell growth, induced; transcription, induced; signaling pathway regulation; transcription, altered; cell growth, altered DNA(INDUCES) 10744710; 11413148; 12091337; 12529425; 20028972; 25143441; 26710253; 32122995; 34535769; 36356831; 36773294 156 50 2180 induces IL-2 signaling -PDE4D PDE4D iso4 EC 3.1.4.53; Nucleotide Metabolism - purine; Phosphodiesterase Q08499-4 5144 5q11.2-q12.1 human S490-p 451090 YQSTIPQsPSPAPDD enzymatic activity, induced 10828059 7 3 0 -TH TH Amino Acid Metabolism - tyrosine; EC 1.14.16.2; Endoplasmic reticulum; Mitochondrial; Oxidoreductase; Vesicle P07101 7054 11p15.5 human S40-p 1876194200 GQGAPGPsLTGSPWP TOH_N molecular association, regulation; protein conformation; enzymatic activity, induced Other(DISRUPTS) 35013193 1 0 0 inhibits binding to Dopamine -YAP1 YAP1 iso3 Oncoprotein; Transcription, coactivator/corepressor P46937-3 10413 11q22.1 human Y357-p 473004 SGLSMSSySVPRTPD activity, induced; molecular association, regulation; intracellular localization carcinogenesis, induced; carcinogenesis, inhibited; apoptosis, induced; cell growth, induced; transcription, induced TEAD1(INDUCES); p73(INDUCES) 27013234; 34697383; 35015027 23 3 4 -Trpv2 TRPV2 Channel, cation; Membrane protein, integral; Membrane protein, multi-pass Q9WUD2 29465 10q23 rat Y525-p 2527084 GFQHTGIySVMIQKV Ion_trans activity, induced; protein stabilization endocytosis, induced 35686730 1 1 0 -KAT7 MYST2 ACETYLTRANSFERASE; Acetyltransferase; EC 2.3.1.48; Nuclear receptor co-regulator; Transcription, coactivator/corepressor O95251 11143 17q21.33 human S57-p 460899 SQSSQDSsPVRNLQS cell cycle regulation; carcinogenesis, induced; apoptosis, inhibited; transcription, induced 18250300; 23188630 2 55 52 -KHSRP KHSRP RNA-binding Q92945 8570 19p13.3 human S274-p 482097 MILIQDGsQNTNVDK KH_1 activity, induced; molecular association, regulation 21329876 1 15 15 binds to and functions in pri-miRNA processing -SMAD2 SMAD2 DNA-binding; Transcription factor Q15796 4087 18q21.1 human K19-ac 470076 VKRLLGWkKSAGGSG molecular association, regulation; intracellular localization; protein conformation cell cycle regulation; cell growth, inhibited; transcription, induced; signaling pathway regulation DNA(INDUCES) 17074756; 17478422; 29187201 3 1 4 -RUNX1/RUNX1T1 fusion AML1-ETO A0A7S8LV65 human K58-ac 1880757300 AGAALAGkLRSGDRS transcription, induced 31699991 1 1 0 -ABI1 Abi-1 Adaptor/scaffold; Motility/polarity/chemotaxis Q8IZP0 10006 10p12.1 human T394-p 12626406 ENIADSPtPPPPPPP molecular association, regulation cell motility, altered; cytoskeletal reorganization 21419341 1 1 0 regulates WRC (WAVE2 regulatory complex) interaction with Arp2/3 and lamellipodial protrusion -Dlc1 DLC1 GAP; GAP, Rac/Rho; Tumor suppressor Q9R0Z9 50768 8 A4|8 23.05 cM mouse Y452-p 1869008602 NVPGSILySSSGELA molecular association, regulation carcinogenesis, induced; cell growth, induced; apoptosis, inhibited tensin 1 iso1(DISRUPTS) 31308216 1 1 0 Rho-GAP activity -Dok3 DOK3 Adaptor/scaffold Q9QZK7 27261 13|13 B1 mouse Y325-p 454685 EGPASGLyASVCKQT molecular association, regulation CSK(INDUCES); SHIP(INDUCES) 14993273 1 2 15 -NUP153 NUP153 Nuclear export; Nucleoporin P49790 9972 6p22.3 human S529-p 452707 SPMFKFSsPIVKSTE Nup153 molecular association, regulation KPNB1(DISRUPTS) 19767751 1 18 0 -Cers2 LASS2 DNA-binding; Membrane protein, integral; Membrane protein, multi-pass; Transferase Q924Z4 76893 3|3 F2.1 mouse S341-p 470692 KLIEDERsDREETES enzymatic activity, induced 26887952 1 47 217 -NFKB2 NFkB-p100 DNA-binding; Oncoprotein; Transcription factor Q00653 4791 10q24.32 human K298-sm 3055608 TPPYHKMkIERPVTV RHD_dimer protein processing; phosphorylation signaling pathway regulation 18617892 1 0 0 activation of alternative NF-kB pathway -YAP1 YAP1 Oncoprotein; Transcription, coactivator/corepressor P46937 10413 11q22.1 human S436-p 1874499600 INQSTLPsQQNRFPD activity, induced; protein stabilization; molecular association, regulation; intracellular localization carcinogenesis, induced; cell motility, induced; cell growth, induced; transcription, induced TEAD1(INDUCES); TEAD4(INDUCES); TEAD3(INDUCES); TEAD2(INDUCES) 34343821 1 0 0 -Lepr LEPR Membrane protein, integral; Receptor, cytokine Q62959 rat Y985-p 448435 QSQPSVKyATLVSNV activity, induced; molecular association, regulation neural plasticity ARHGEF7(INDUCES) 34006608 16 0 0 Interaction leads to developmental increase in GABAergic synaptogenesis -Kcne1 KCNE1 Channel, potassium; Membrane protein, integral P15383 25471 11q11 rat S103-p 10349700 FQARVLEsFRACYVI ISK_Channel activity, inhibited 1553557 5 0 0 -EGFR EGFR EC 2.7.10.1; KINASE; Kinase, protein; Membrane protein, integral; Oncoprotein; Protein kinase, TK; Protein kinase, tyrosine (receptor) P00533 1956 7p11.2 human K745-m1 63106400 VKIPVAIkELREATS PK_Tyr_Ser-Thr molecular association, regulation; phosphorylation; enzymatic activity, induced cell cycle regulation; carcinogenesis, induced; signaling pathway regulation PCNA(INDUCES) 28102297 1 1 0 inhibits EGFR?s downstream signaling pathway involving RAS, RAF, MEK and ERK; activates phosphorylation of itself at other sites -OCLN occludin Cell adhesion; Membrane protein, integral; Membrane protein, multi-pass; Motility/polarity/chemotaxis A2VE81 512405 cow S490-p 6094300 RLKQVKGsADYKSKR Occludin_ELL intracellular localization cell motility, induced; cell growth, induced 27423695 11 1 0 VEGF-induced tube formation, VEGF-induced tube formation, localizes to centrosomes, retinal neovascularization -ZBTB16 PLZF C2H2-type zinc finger protein; DNA-binding; Oncoprotein; Transcription, coactivator/corepressor Q05516 7704 11q23.2 human K650-ac 50455004 SSMQKHMkGHKPEEI molecular association, regulation; acetylation; intracellular localization chromatin organization, altered; transcription, inhibited DNA(INDUCES) 26405459 1 0 0 induces histone acetylation and DNA hypermethylation -ZNRF2 ZNRF2 EC 6.3.2.-; EC 6.3.2.19; Ligase; UBIQUITIN LIGASE; Ubiquitin conjugating system; Ubiquitin ligase Q8NHG8 223082 7p14.3 human S145-p 4742836 GPRLVIGsLPAHLSP intracellular localization 27244671 1 28 10 -RELA NFkB-p65 DNA-binding; Nuclear receptor co-regulator; Transcription factor Q04206 5970 11q13.1 human K314-ac 1985900 ETFKSIMkKSPFSGP molecular association, regulation; intracellular localization carcinogenesis, induced; cell motility, induced; cell growth, induced; transcription, induced; transcription, inhibited; transcription, altered DNA(DISRUPTS) 18263619; 20064247; 23087373; 28167529; 31939185; 34626802 7 1 0 recruited to the IL-8 promoter -E2F1 E2F1 DNA-binding; Transcription factor Q01094 1869 20q11.22 human K266-sm 1876998410 EQMVMVIkAPPETQL E2F_CC-MB cell cycle regulation; transcription, inhibited 32541040 1 1 0 -NPR1 ANPA EC 4.6.1.2; Guanylyl cyclase; KINASE; Kinase, protein; Lyase; Membrane protein, integral; Nucleotide Metabolism - purine; Protein kinase, RGC; Protein kinase, dual-specificity (receptor); Receptor, misc. P16066 4881 1q21.3 human S538-p 447515 LTLSGRGsNYGSLLT activity, induced; enzymatic activity, induced 28416574; 9528788 3 2 0 -GABRB2 GABRB2 Channel, chloride; Channel, ligand-gated; Membrane protein, integral; Membrane protein, multi-pass; Transporter; Transporter, ion channel P47870 2561 5q34 human T389-p 10769102 LSPTRRTtNYDFSLY Neur_chan_memb activity, inhibited 19763268 1 0 0 channel current run-down is reduced in T389A mutant receptor; i.e., phosphorylation may contribute to channel inhibition -Btk Btk EC 2.7.10.2; KINASE; Kinase, protein; Protein kinase, TK; Protein kinase, tyrosine (non-receptor) P35991 12229 X E3|X 56.18 cM mouse Y375-p 457681 GLISRLKyPVSKQNK not reported 16291652 1 3 22 mutation of site in transfection assays or knock-in mice had no significant effect on biological function. -Kcnb1 Kv2.1 Channel, cation; Channel, ligand-gated; Channel, potassium; Membrane protein, integral; Membrane protein, multi-pass P15387 25736 3q42 rat S457-p 473558 MKDAFARsIEMMDIV activity, inhibited 16917065 4 6 0 -GTF2I GTF2I iso2 DNA-binding; Transcription, coactivator/corepressor P78347-2 2969 7q11.23 human S627-p 452349 INTKALQsPKRPRSP transcription, altered 10648599 1 11 5 -PPP1R1A PPP1R1A Inhibitor; Protein phosphatase, regulatory subunit Q13522 5502 12q13.2 human S67-p 447758 LKSTLAMsPRQRKKM DARPP-32 phosphorylation; enzymatic activity, induced cytoskeletal reorganization 10811908; 17416610 12 14 2 decreased contractility, and decreased PLB phosphorylation in PPP1R1A S67D and T75D mutants -NFAT5 NFAT5 Transcription factor O94916 10725 16q22.1 human S155-p 2715402 PEDLLDNsRMSCQDE intracellular localization 18411282; 21209322 3 4 2 -NELFCD NELFCD iso4 Adaptor/scaffold Q8IXH7-4 51497 20q13.32 human Y6-p 23003806 __MDEDYyGSAAEWG TH1 protein degradation; molecular association, regulation; phosphorylation cell motility, induced; signaling pathway regulation PAK1(DISRUPTS); ARAF(DISRUPTS) 22238675 1 0 0 MAPK/ERK signaling, enhanced ERK phosphorylation -Krt17 K17 Cytoskeletal Q9QWL7 16667 11 D|11 63.44 cM mouse S44-p 464291 AGSCRLGsASGLGSA molecular association, regulation cell cycle regulation 14-3-3 sigma(NOT_REPORTED) 16710422 2 1 0 Mutation of T8 and S43 (to alanine) causes reduced phosphorylation of Akt S473 and p70S6K T389. -Ppargc1a PGC-1 alpha Nuclear receptor co-regulator; Transcription, coactivator/corepressor Q9QYK2 rat S569-p 2045307 RMRSRSRsFSRHRSC acetylation; activity, inhibited transcription, altered 19940161 4 0 0 -UBA52-RPS27A-UBB-UBC ubiquitin Ubiquitin-like modifier P62989 rat S65-p 9765472 DYNIQKEsTLHLVLR ubiquitin molecular association, regulation autophagy, induced RHOT1(INDUCES) 30504269 27 17 0 mitochondrial depolarization -BAD BAD Apoptosis Q92934 572 11q13.1 human R94-m2 51576300 GEEPSPFrGRSRSAP Bcl-2_BAD molecular association, regulation; phosphorylation 14-3-3 beta(DISRUPTS) 21444773 1 0 0 methylation of BAD inhibits S99 phosphorylation by Akt, and binding to 14-3-3-beta -Crtc1 TORC1 Transcription factor Q68ED7 382056 8|8 B3.3 mouse S167-p 18255800 MTPSQAEsFTGGSQD TORC_M intracellular localization transcription, induced 28076781 2 0 0 nuclear import and retention -Rims1 RIMS1 iso7 Adaptor/scaffold; Vesicle Q99NE5-7 116837 1|1 A5 mouse S413-p 450481 ARHERRHsDVALPHT molecular association, regulation 14-3-3 epsilon(INDUCES) 18799741 4 6 0 -FOXO3 FOXO3A Autophagy; DNA-binding; Oncoprotein; Transcription factor O43524 2309 6q21 human K569-ac 460597 SSSLGSAkHQQQSPV protein stabilization; molecular association, regulation; ubiquitination apoptosis, induced; transcription, induced JNK1(INDUCES); SKP2(DISRUPTS) 21841822; 27669435 3 0 0 -Mapt Tau ACETYLTRANSFERASE; Acetyltransferase; Cytoskeletal P19332 29477 10q32.1 rat T516-p 447933 SSPGSPGtPGSRSRT molecular association, regulation; protein conformation PPP1CC(INDUCES) 28784767; 36859689 142 27 26 -TFB2M TFB2M EC 2.1.1.-; METHYLTRANSFERASE; Methyltransferase; Transcription, coactivator/corepressor Q9H5Q4 64216 1q44 human T184-p 25756119 GIEAVPWtADIPLKV RrnaAD molecular association, regulation transcription, inhibited POLRMT(DISRUPTS) DNA(DISRUPTS) 32505352 1 0 1 -BLNK BLNK Adaptor/scaffold Q8WV28 29760 10q24.1 human T152-p 23303201 EKARLTStLPALTAL molecular association, regulation; protein conformation 14-3-3 sigma(INDUCES); 14-3-3 zeta(INDUCES); 14-3-3 gamma(INDUCES) 33176192 2 0 0 -FERMT2 kindlin-2 Cytoskeletal; Motility/polarity/chemotaxis Q96AC1 10979 14q22.1 human S177-p 4760248 LITPGSGsIYSSPGL protein degradation; molecular association, regulation; ubiquitination cell cycle regulation; cell growth, induced; apoptosis, inhibited; cytoskeletal reorganization; cell adhesion, inhibited CUL9(INDUCES) 35469017 1 3 1 -RORA RORA iso4 DNA-binding; Nuclear receptor P35398-4 6095 15q22.2 human T128-p 482887 PGEAEPLtPTYNISA activity, inhibited transcription, inhibited DNA(DISRUPTS) 17512500 1 0 0 -Nrip1 RIP140 Nuclear receptor co-regulator; Transcription, coactivator/corepressor Q8CBD1 268903 16|16 C3.1 mouse K482-ac 459038 KIPGVDIkEDQDTST NRIP1_repr_2 intracellular localization transcription, inhibited 15879431 0 2 0 -Cd79b Ig-beta Membrane protein, integral; Receptor, misc. P15530 15985 11 E1|11 68.89 cM mouse Y195-p 459286 GMEEDHTyEGLNIDQ ITAM phosphorylation 9531288 2 1 5 -CTNNB1 CTNNB1 Actin-binding; Cell adhesion; Motility/polarity/chemotaxis; Nuclear receptor co-regulator; Oncoprotein; Transcription factor XP_008258482 100125985 rabbit S33-p 447487 QQQSYLDsGIHSGAT protein degradation cell differentiation, inhibited 34094857 112 3 2 -Mcl1 MCL1 Apoptosis; Channel, misc.; Inhibitor; Membrane protein, integral; Mitochondrial P97287 17210 3 F2.1|3 40.74 cM mouse T144-p 455375 ADGSLPStPPPPEEE protein stabilization; molecular association, regulation PIN1(INDUCES) 17670986 20 17 8 -Flt3 FLT3 EC 2.7.10.1; KINASE; Kinase, protein; Membrane protein, integral; Oncoprotein; Protein kinase, TK; Protein kinase, tyrosine (receptor) Q00342 14255 5 86.88 cM|5 G3 mouse Y922-p 456470 FYATEGIyFVMQSCW PK_Tyr_Ser-Thr protein stabilization; enzymatic activity, induced 16091740 1 0 0 -Crtc2 TORC2 Transcription, coactivator/corepressor Q3U182 74343 3|3 F1 mouse S171-p 454622 SALNRTSsDSALHTS TORC_M protein degradation; molecular association, regulation; enzymatic activity, inhibited; intracellular localization; activity, inhibited carcinogenesis, inhibited; transcription, inhibited; signaling pathway regulation; transcription, altered 14-3-3 beta(INDUCES); COP1(NOT_REPORTED) 15454081; 16148943; 17805301; 18323454; 18626018; 19254569; 19543265; 20551288; 26342077; 29941929; 33127851 19 10 12 -WASL N-WASP Adaptor/scaffold; Motility/polarity/chemotaxis O00401 8976 7q31.32 human S485-p 3149547 RSKAIHSsDEDEDED molecular association, regulation; intracellular localization; phosphorylation cell motility, induced; cytoskeletal reorganization PAK4(INDUCES) 21898535; 29100370 3 19 1 -RARA RARA DNA-binding; Nuclear receptor; Oncoprotein; Transcription factor P10276 5914 17q21.2 human S219-p 13373501 NSSEQRVsLDIDLWD molecular association, regulation; intracellular localization; activity, inhibited transcription, inhibited RXRA(DISRUPTS) 20215566 1 0 0 -BAD BAD Apoptosis Q92934 572 11q13.1 human T137-p 1904506 PRPKSAGtATQMRQS Bcl-2_BAD activity, induced 10827191 2 0 0 -MCL1 MCL1 Apoptosis; Channel, misc.; Inhibitor; Membrane protein, integral; Mitochondrial Q07820 4170 1q21.2 human K279-ub 12107118 AFVAKHLkTINQESC Bcl-2 protein degradation 28522751 1 1 4 -CHEK2 Chk2 EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, CAMK; Protein kinase, Ser/Thr (non-receptor); Tumor suppressor O96017 11200 22q12.1 human S35-p 447550 SQGSSSQsQGISSSS molecular association, regulation; enzymatic activity, induced cell cycle regulation Chk2(INDUCES); PPP2CA(DISRUPTS) 16940182; 20160490 10 1 0 S19A mutant shows impaired dimerization and does not promote Hdmx degradation -SIRT2 SIRT2 DEACETYLASE; Deacetylase; EC 3.5.1.- Q8IXJ6 22933 19q13.2 human S372-p 482810 TSASPKKsPPPAKDE enzymatic activity, induced 17516032 2 21 1 enzymatic activity of mutant S368A/S372A (but not S386A) was reduced 44% -IRS1 IRS1 Adaptor/scaffold; Motility/polarity/chemotaxis P35568 3667 2q36.3 human S330-p 447559 SFRVRASsDGEGTMS intracellular localization 34253290 4 17 5 disassociation of IRS2 from plasma membrane to cytosol; limits PM-associated PI3K and PIP3 synthesis -TNFAIP8L2 TNFAIP8L2 Q6P589 79626 1q21.3 human S3-p 56660955 _____MEsFSSKSLA protein degradation; molecular association, regulation; ubiquitination BTRC(INDUCES) 32188758 1 1 0 -BCL2L1 Bcl-xL Apoptosis; Autophagy; Membrane protein, integral; Mitochondrial Q07817 598 20q11.21 human K87-ub 12109292 VIPMAAVkQALREAG protein degradation apoptosis, induced 31792461 1 6 3 -MZF1 MZF-1 C2H2-type zinc finger protein; DNA-binding; Transcription factor P28698 7593 19q13.43 human K23-sm 1870848902 DEGPVMVkLEDSEEE activity, induced; protein conformation; phosphorylation 30622337 1 0 0 -PEX14 PEX14 Adaptor/scaffold O75381 5195 1p36.22 human S232-p 455420 NRRQFPPsPSAPKIP molecular association, regulation; protein conformation PEX14(INDUCES) 32854114 2 20 86 -TERF1 TRF1 DNA-binding P54274 7013 8q21.11 human T271-p 60179301 VESKRTRtITSQDKP molecular association, regulation cell cycle regulation DNA(INDUCES) 27841304 1 1 0 suppress telomerase-dependent telomere lengthening, phosphorylation on T271 is necessary for formation ALT-associated PML bodies (APBs) -EIF3F eIF3-epsilon EC 3.4.19.12; Translation; Translation initiation O00303 8665 11p15.4 human S46-p 448818 PAAAPASsSDPAAAA transcription, altered 12446680 2 1 0 -FLT3 FLT3 EC 2.7.10.1; KINASE; Kinase, protein; Membrane protein, integral; Oncoprotein; Protein kinase, TK; Protein kinase, tyrosine (receptor) P36888 2322 13q12.2 human Y842-p 454872 DIMSDSNyVVRGNAR PK_Tyr_Ser-Thr protein conformation; phosphorylation apoptosis, inhibited; cell growth, altered 15345593 5 2 76 FLT3 Y842C -transfected cells show constitutive FLT3 tyrosine phosphorylation and activation -Ppara PPAR-alpha DNA-binding; Nuclear receptor; UBIQUITIN LIGASE P37230 25747 7q34 rat S142-p 457550 AYDKCDRsCKIQKKN zf-C4 activity, induced transcription, altered 16042408 1 0 0 -HSD17B4 HSD17B4 Cell development/differentiation; EC 1.1.1.n12; EC 4.2.1.107; EC 4.2.1.119; Lipid Metabolism - primary bile acid biosynthesis; Lyase; Mitochondrial; Oxidoreductase P51659 3295 5q23.1 human S318-p 7445507 NHTSRATsTATSGFA protein degradation; molecular association, regulation; ubiquitination cell growth, induced; transcription, induced SKP2(INDUCES); SPOP(DISRUPTS) 33762355 1 9 12 -Pparg PPAR-gamma iso2 DNA-binding; Nuclear receptor; Transcription factor P37238-2 19016 6 E3|6 53.41 cM mouse S16-p 12170300 WPTNFGIsSVDLSVM PPARgamma_N intracellular localization transcription, altered 20026644 1 0 0 -ATXN1 ataxin-1 Nuclear export; RNA-binding P54253 6310 6p22.3 human S775-p 449110 ATRKRRWsAPESRKL protein degradation; protein stabilization; molecular association, regulation; intracellular localization cell growth, induced; transcription, induced; cytoskeletal reorganization 14-3-3 beta(INDUCES); 14-3-3 sigma(INDUCES); U2AF2(DISRUPTS); RBM17(DISRUPTS); 14-3-3 zeta(INDUCES); 14-3-3 epsilon(INDUCES); RBM17(INDUCES) 12741986; 12757707; 17540008; 20037628; 23213356; 23719381; 24858692; 29212253; 29758256; 33709453; 34302818 19 28 3 ataxin-1 S776A mutant reduces nuclear inclusion bodies of ataxin-1 in B05 tg/+ mice.; increased the expressions of cyclin D1; proliferation of cervical cancer cells; involved in the regulation of cyclin D1 transcription -XRCC1 XRCC1 DNA repair, damage P18887 7515 19q13.31 human S518-p 451449 GEDPYAGsTDENTDS molecular association, regulation; intracellular localization PARP1(DISRUPTS); APTX(INDUCES); Pnk1(INDUCES) 15066279; 15367657; 25477519 4 5 6 -CAMK2D CAMK2D EC 2.7.11.17; KINASE; Kinase, protein; Protein kinase, CAMK; Protein kinase, Ser/Thr (non-receptor) Q13557 817 4q26 human T336-p 484560 ESTESSNtTIEDEDV enzymatic activity, altered 34391760 1 21 5 -DPYSL3 CRMP-4 Hydrolase Q14195 1809 5q32 human K374-sm 1881371306 DKAVATGkMDENQFV molecular association, regulation cell growth, induced CACNA1C(DISRUPTS) 34645092 1 0 0 deSUMOylation of CRMP4 further promotes the neurite growth of cortical neurons, deSUMOylation of CRMP4 promotes thermal pain sensitivity in rats. -FANCD2 FANCD2 DNA repair, damage Q9BXW9 2177 3p25.3 human S592-p 453230 MAADRSEsPSLTQER FancD2 ubiquitination cell cycle regulation; chromatin organization, altered; cell growth, induced 34096775 1 23 6 induces monoubiquitination -PDE3A PDE3A EC 3.1.4.17; Membrane protein, integral; Membrane protein, multi-pass; Nucleotide Metabolism - purine; Phosphodiesterase Q14432 5139 12p12.2 human S438-p 456984 PGLLRRVsSTWTTTT enzymatic activity, induced cell growth, induced 25961942 4 6 9 -MARK1 MARK1 EC 2.7.11.1; EC 2.7.11.26; KINASE; Kinase, protein; Protein kinase, CAMK; Protein kinase, Ser/Thr (non-receptor) Q9P0L2 4139 1q41 human K783-ub 22247227 SGTSIAFkNIASKIA KA1 protein stabilization transcription, induced 28969054 1 4 0 -SLAMF1 SLAM Membrane protein, integral; Receptor, misc. Q13291 6504 1q23.3 human Y327-p 447634 ETNSITVyASVTLPE molecular association, regulation SHP-2(INDUCES); SH2D1A(INDUCES); APCS(INDUCES) 11806999; 15315965 3 0 0 -NEDD1 NEDD1 Cell cycle regulation Q8NHV4 121441 12q23.1 human T382-p 9379001 PRSINTDtLSKETDS molecular association, regulation cell cycle regulation 19509060 2 1 0 important for binding of NEDD1 with gamma-tubulin -HAUS8 HAUS8 Cell cycle regulation Q9BT25 93323 19p13.11 human S143-p 20609210 RKKSPDLsEAMEMME intracellular localization cell cycle regulation; apoptosis, inhibited 21690413 1 0 0 localization to the spindle -BAD BAD Apoptosis Q92934 572 11q13.1 human S74-p 5209400 VEIRSRHsSYPAGTE Bcl-2_BAD molecular association, regulation; phosphorylation Bcl-2(DISRUPTS) 22096607 2 9 71 mutation of this site to Ala reduces S75 phosphorylation -KARS1 KARS Aminoacyl-tRNA synthetase; EC 6.1.1.6; Ligase; Mitochondrial; Translation; Translation regulation Q15046 3735 16q23.1 human S207-p 9392600 PYEITLLsPCLHMLP intracellular localization; enzymatic activity, induced transcription, induced 19524539; 29029422; 30188867 4 1 0 -MDC1 MDC1 Cell cycle regulation Q14676 9656 6p21.33 human S453-p 453670 QTTTERDsDTDVEEE molecular association, regulation cell cycle regulation NBS1(INDUCES) 18678890 1 34 96 MDC1-NBS1 interaction regulates intra-S-phase checkpoint activation -BAIAP2 IRSp53 Actin-binding; Motility/polarity/chemotaxis Q9UQB8 10458 17q25.3 human T360-p 4751846 YATTENKtLPRSSSM molecular association, regulation cytoskeletal reorganization 14-3-3 zeta(INDUCES) 19933840 1 20 17 -STK3 MST2 Autophagy; EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, STE; Protein kinase, Ser/Thr (non-receptor) Q13188 6788 8q22.2 human S18-p 20831306 LKKLSEDsLTKQPEE molecular association, regulation cell cycle regulation NEK2(DISRUPTS) 21723128 2 3 0 -RIGI RIGI EC 3.6.4.13; Hydrolase O95786 23586 9p21.1 human K172-ub 486285 ENWPKTLkLALEKER CARD_2 activity, induced; molecular association, regulation; ubiquitination transcription, induced; signaling pathway regulation MAVS(INDUCES); NPL4(INDUCES) 17392790; 19484123; 20403326; 23063562; 26471729; 28948228; 29263274 8 3 0 regulates RIG-I activation and RIG-I-mediated IFN-B induction and antiviral capacity; induces ubiquitination at K181; activation of RIG-I mediated by CARD2; K172 is surface accessible, conformational exchange leads to sampling an excited state with an open conformation around T170; regulates antiviral innate immune response signaling; induces DDX58-mediated innate antiviral activity; induces NF-kB signaling; K63-Ubiquitin chains are necessary for activation -SORBS2 ArgBP2 iso2 Adaptor/scaffold; Motility/polarity/chemotaxis O94875-2 8470 4q35.1 human Y50-p 31834902 AVSPMSYyQRPFSPS protein conformation 24475245 1 0 0 reduced self-interaction -GSK3B GSK3B EC 2.7.11.1; EC 2.7.11.26; KINASE; Kinase, protein; Protein kinase, CMGC; Protein kinase, Ser/Thr (non-receptor) P49841 2932 3q13.33 human S389-p 454221 ARIQAAAsTPTNATA intracellular localization; phosphorylation signaling pathway regulation 22039048; 34948382 6 13 0 p38MAPK/GSK-3beta/beta-catenin signaling pathway; inhibits mTOR complex 1 signaling, primes phosphorylation at S9 and inhibits phosphorylation of p70S6K, enhances cardiomyocyte survival and protects from cardiomyocyte hypertrophy; B-catenin nuclear accumulation -KEAP1 KEAP1 Endoplasmic reticulum; Motility/polarity/chemotaxis; Transcription regulation; UBIQUITIN LIGASE; Ubiquitin conjugating system Q14145 9817 19p13.2 human S293-p 4270135 QKCEILQsDSRCKDY transcription, inhibited 30576774 1 2 0 NQO1, Nrf2 expression reduced -NCBP1 NCBP1 RNA processing; Spliceosome; Translation Q09161 4686 9q22.33 human S22-p 1219020 PHKRRKTsDANETED RNA splicing, altered 10973943 1 45 29 -SHOC2 SHOC2 Adaptor/scaffold; Protein phosphatase, regulatory subunit Q9UQ13 8036 10q25.2 human S297-p 31905007 GLRYNRLsAIPRSLA LRR_8 protein degradation; ubiquitination cell growth, inhibited; cell motility, inhibited 29383184 1 2 0 -FLNA FLNA Actin-binding; Motility/polarity/chemotaxis; Nuclear receptor co-regulator P21333 2316 Xq28 human S2152-p 451357 TRRRRAPsVANVGSH Filamin molecular association, regulation; protein stabilization cell cycle regulation; carcinogenesis, induced; cell motility, induced; cell adhesion, induced; transcription, altered; cell motility, altered; apoptosis, inhibited; cytoskeletal reorganization MKL1(INDUCES); LPAR1(INDUCES); GPIbA(INDUCES); CCND1(DISRUPTS) 12198493; 15024089; 16442073; 20179208; 25944616; 28348077; 32195017; 36577757 19 80 999 -Fer Fer EC 2.7.10.2; KINASE; Kinase, protein; Oncoprotein; Protein kinase, TK; Protein kinase, tyrosine (non-receptor) P70451 14158 17|17 E1.1 mouse Y715-p 448461 RQEDGGVySSSGLKQ PK_Tyr_Ser-Thr cell cycle regulation; cell motility, altered 18515860 3 34 611 -USP15 USP15 DEUBIQUITINASE; EC 3.4.19.12; Protease; Ubiquitin conjugating system; Ubiquitin-specific protease Q9Y4E8 9958 12q14.1 human T149-p 1868913300 GNMNNVVtRRFSKAD Ubiquitin_3 molecular association, regulation; ubiquitination; intracellular localization SART3(DISRUPTS) 31330151 1 1 0 inhibits deubiquitination of PRP31 -Gabrg2 GABRG2 Channel, chloride; Channel, ligand-gated; Membrane protein, integral; Membrane protein, multi-pass; Transporter; Transporter, ion channel P22723 14406 11 A5|11 24.8 cM mouse K368-ub 14694706 NRKPSKDkDKKKKNP Neur_chan_memb protein degradation; receptor internalization, altered 19815531 1 0 0 regulation of the late endosomal/lysosomal trafficking of GABA receptors, regulation of synaptic transmission -MAPT Tau iso8 ACETYLTRANSFERASE; Acetyltransferase; Cytoskeletal P10636-8 4137 17q21.31 human K259-ac 1881568102 DLKNVKSkIGSTENL molecular association, regulation 34426645 1 0 0 reduced tau microtuble interactions -Pou5f1 Oct4 DNA-binding; Transcription factor P20263 18999 17 B1|17 18.69 cM mouse K118-sm 486291 ADRPNAVkLEKVEPT protein stabilization cell differentiation, inhibited; cell growth, induced; transcription, induced 17496161 4 0 0 -IRS1 IRS1 Adaptor/scaffold; Motility/polarity/chemotaxis P35568 3667 2q36.3 human K1189-ub 1873529900 LDLVKDFkQCPQECT molecular association, regulation; phosphorylation cell growth, induced; signaling pathway regulation IGF1R(INDUCES) 33991522 1 0 0 regulates IRS1-tyrosine phosphorylation and IGF1-mediated downstream signaling -ABI1 Abi-1 Adaptor/scaffold; Motility/polarity/chemotaxis Q8IZP0 10006 10p12.1 human S392-p 12626405 VQENIADsPTPPPPP molecular association, regulation cell motility, altered; cytoskeletal reorganization 21419341 1 1 0 regulates WRC (WAVE2 regulatory complex) interaction with Arp2/3 and lamellipodial protrusion -H3C1 H3 DNA-binding P68431 8350 6p22.2 human K27-m1 465522 LATKAARkSAPATGG Histone apoptosis, induced 19609857 22 20 47 induced by staurosporine -TFAP4 AP-4 DNA-binding; Transcription factor Q01664 7023 16p13.3 human S139-p 470462 DKDEGIGsPDIWEDE protein degradation; molecular association, regulation; intracellular localization cell cycle regulation BTRC(INDUCES) 24500709 1 24 0 -Scn2a SCN2A Channel, sodium; Membrane protein, integral; Membrane protein, multi-pass P04775 24766 3q21 rat S1112-p 6003508 VPIALGEsDFENLNT Na_trans_assoc intracellular localization 19064667 1 0 0 regulates SCN2A accumulation at the axonal initial segment (AIS) and interaction with ankyrin G -FLT4 VEGFR3 EC 2.7.10.1; KINASE; Kinase, protein; Membrane protein, integral; Protein kinase, TK; Protein kinase, tyrosine (receptor) P35916 2324 5q35.3 human Y1230-p 4119675 RHSLAARyYNWVSFP molecular association, regulation; enzymatic activity, induced cell motility, induced; cell growth, induced GRB2(INDUCES) 16076871 2 0 1 -Irs2 IRS2 Adaptor/scaffold; Motility/polarity/chemotaxis P81122 384783 8 A1.1|8 5.35 cM mouse S303-p 3217341 EFRPRSKsQSSGSSA molecular association, regulation signaling pathway regulation PIK3R1(DISRUPTS) 23775122 3 39 26 -CTNNB1 CTNNB1 Actin-binding; Cell adhesion; Motility/polarity/chemotaxis; Nuclear receptor co-regulator; Oncoprotein; Transcription factor P35222 1499 3p22.1 human Y489-p 462002 QNAVRLHyGLPVVVK molecular association, regulation; intracellular localization transcription, induced LEF-1(INDUCES); CDH2(DISRUPTS) 17618275; 32075752 3 8 91 -MIF MIF Amino Acid Metabolism - phenylalanine; Amino Acid Metabolism - tyrosine; Apoptosis; Cell development/differentiation; Cytokine; EC 5.3.2.1; EC 5.3.3.12; Isomerase P14174 4282 22q11.23 human T113-gl 48990004 NVGWNNStFA_____ MIF molecular association, regulation carcinogenesis, inhibited; cell growth, inhibited; cell motility, inhibited EGFR(INDUCES) 26280537 1 1 0 binds to EGFR and blocks EGF binding to EGFR -POLH POLH DNA repair, damage; EC 2.7.7.7; Transferase Q9Y253 5429 6p21.1 human K589-sm 1877365911 SKLEESSkATPAEMD intracellular localization; enzymatic activity, inhibited 32350109 1 1 0 -BECN1 beclin 1 Adaptor/scaffold; Autophagy; Membrane protein, peripheral Q14457 8678 17q21.31 human T388-p 56689904 EEVEKGEtRFCLPYR APG6 molecular association, regulation autophagy, induced Bcl-2(DISRUPTS); PIK3C3(INDUCES); ATG14(INDUCES) 27304906 1 0 0 -Grin2b NMDAR2B Channel, calcium; Channel, ligand-gated; Membrane protein, integral; Membrane protein, multi-pass Q00960 24410 4q43 rat Y1472-p 448167 GSSNGHVyEKLSSIE NMDAR2_C molecular association, regulation; receptor recycling, induced neural plasticity; endocytosis, induced PSD-95(INDUCES) 16887807; 22819974; 23376245; 24769228; 33558223 42 1 104 -SPIC SPIC DNA-binding Q8N5J4 121599 12q23.2 human Y191-p 15570419 KIRRKLTyQFSEAIL Ets intracellular localization cell adhesion, induced; transcription, induced 35420633 1 0 3 -GJA1 GJA1 Channel, misc.; Membrane protein, integral; Membrane protein, multi-pass; Motility/polarity/chemotaxis P17302 2697 6q22.31 human S279-p 448853 SSPTAPLsPMSPPGY protein degradation; protein stabilization; molecular association, regulation; ubiquitination; intracellular localization; activity, inhibited; protein conformation carcinogenesis, induced; carcinogenesis, inhibited; cell motility, induced; apoptosis, induced; cell growth, inhibited; signaling pathway regulation; endocytosis, induced; cell growth, induced; cytoskeletal reorganization CLTA(INDUCES) 15958277; 18047584; 22737133; 23828237; 24399133; 24492000; 24742583; 26033246; 33255329; 35949588 42 6 1 -TDP1 TDP1 DNA repair, damage; EC 3.1.4.-; Phosphodiesterase Q9NUW8 55775 14q32.11 human R361-m2 1883845000 LIGSTPGrFQGSQKD enzymatic activity, induced DNA repair, induced 35705029 1 0 0 -MAPT Tau iso8 ACETYLTRANSFERASE; Acetyltransferase; Cytoskeletal P10636-8 4137 17q21.31 human T175-p 449077 ATRIPAKtPPAPKTP intracellular localization apoptosis, induced; cytoskeletal reorganization TUBB1(DISRUPTS) 19046355; 25573097; 29298849 10 8 0 fibril formation; colocalization- a subset of pThr 231 tau pathology is also pThr 175 positive; T175 phosphorylation induced increased fibril formation and cell death. -CHRM1 mAChR m1 GPCR, family 1; Membrane protein, integral; Membrane protein, multi-pass; Receptor, GPCR P11229 1128 11q12.3 human S228-p 15721213 ELAALQGsETPGKGG 7tm_1 molecular association, regulation ARRB1(INDUCES) 28652372 2 2 1 followed by arrestin-dependent ERK phosphorylation -Ntrk1 TrkA EC 2.7.10.1; KINASE; Kinase, protein; Membrane protein, integral; Oncoprotein; Protein kinase, TK; Protein kinase, tyrosine (receptor) P35739 59109 2q34 rat Y684-p 447764 DIYSTDYyRVGGRTM PK_Tyr_Ser-Thr molecular association, regulation; enzymatic activity, induced cell cycle regulation; cytoskeletal reorganization; cell growth, altered DNAJA3(INDUCES) 10656690; 14647472; 15753086 14 3 6 -SLC12A5 KCC2 Membrane protein, integral; Membrane protein, multi-pass; Transporter; Transporter, SLC family Q9H2X9 57468 20q13.12 human T1030-p 10045602 DPEKVHLtWTKDKSV activity, inhibited 19665974; 29092909 9 5 1 -Glp1r GLP1R GPCR, family 2; Membrane protein, integral; Membrane protein, multi-pass; Receptor, GPCR P32301 25051 20p12 rat S445-p 451383 CPTSSVSsGATVGSS receptor desensitization, altered 8702711 1 0 0 -LDLRAP1 LDLRAP1 Q5SW96 26119 1p36.11 human S186-p 482659 KEKRDKAsQEGGDVL PID_2 cell cycle regulation 21778424 1 9 9 -Nr3c1 GR DNA-binding; Mitochondrial; Nuclear receptor; Transcription factor P06536 24413 18p11 rat T171-p 451795 TSATGCAtPTEKEFP GCR transcription, inhibited 9603939 7 11 0 -SND1 SND1 RNA-binding; Transcription, coactivator/corepressor Q7KZF4 27044 7q32.1 human T103-p 18015998 CFTIENKtPQGREYG SNase molecular association, regulation; intracellular localization; phosphorylation cell cycle regulation; carcinogenesis, induced; DNA repair, induced; apoptosis, inhibited G3BP-1(INDUCES) 28011284; 35271349 2 8 1 induces phosphorylation of AKT and H2AX; recruitment of SND1 into SGs (stress granules) -Ywhab 14-3-3 beta Adaptor/scaffold P35213 56011 3q42 rat S60-p 450226 VVGARRSsWRVISSI 14-3-3 intracellular localization transcription, altered 12619878 5 0 10 Double mutant inhibited a MEF2 reporter and promotes nuclear localization of HDAC4/GFP. -Fundc1 FUNDC1 Membrane protein, multi-pass; Mitochondrial Q9DB70 72018 X|X A1.2 mouse S17-p 2025377 DYESDDEsYEVLDLT autophagy, induced 31901590 6 7 0 Induced mitophagy -Dpysl2 CRMP-2 Microtubule-binding; Motility/polarity/chemotaxis P47942 25416 15p12 rat S518-p 448081 KTVTPASsAKTSPAK receptor recycling, inhibited; protein degradation; molecular association, regulation neural plasticity TUBA1A(DISRUPTS); endophilin A2(DISRUPTS); ROCK2(DISRUPTS) 24036111; 32848595 9 33 17 -CANX Calnexin Calcium-binding; Endoplasmic reticulum; Membrane protein, integral; Motility/polarity/chemotaxis P27824 821 5q35.3 human S564-p 456360 EEDGGTVsQEEEDRK molecular association, regulation SEC62(INDUCES); TRAP(INDUCES); MRPL12(INDUCES); SEC61A1(INDUCES); SEC61B(INDUCES) 22314232 7 85 48 -CEP55 CEP55 Cancer Testis Antigen (CTA); Cell cycle regulation Q53EZ4 55165 10q23.33 human S428-p 457629 KVAASPKsPTAALNE activity, induced; molecular association, regulation cell cycle regulation PLK1(INDUCES) 16198290 1 38 12 -NCF1 p47phox EC 1.-.-.-; Oxidoreductase P14598 653361 7q11.23 human S328-p 449404 QDAYRRNsVRFLQQR NECFESHC molecular association, regulation; intracellular localization; phosphorylation; enzymatic activity, induced cell growth, induced; signaling pathway regulation CYBA(INDUCES); ACTB(INDUCES) 10559253; 12056906; 16375898; 22460559; 31736979; 31811262; 33139577; 35108370 22 0 0 induces ROS production; LPS-induced activation of p38MAPK and ERK1/2 signaling pathways; induces NADPH oxidase activity, regulates Raf/MEK/ERK1/2/p47phox pathway; regulates ERK1/2 phosphorylation in cells treated with TNF-alpha -CAMK2A CAMK2A EC 2.7.11.17; KINASE; Kinase, protein; Protein kinase, CAMK; Protein kinase, Ser/Thr (non-receptor) Q9UQM7 815 5q32 human T305-p 448802 KLKGAILtTMLATRN molecular association, regulation; intracellular localization NMDAR2B(DISRUPTS) 16436603; 21768120 24 5 1 T305/306 autophosphorylation -Ptprc CD45 EC 3.1.3.48; Membrane protein, integral; Motility/polarity/chemotaxis; PHOSPHATASE; Receptor protein phosphatase, tyrosine P06800 19264 1 E4|1 60.73 cM mouse S998-p 449975 DESSDDDsDSEETSK Y_phosphatase enzymatic activity, induced 10066810 1 4 0 -ACBD5 ACBD5 iso2 Lipid-binding; Membrane protein, integral Q5T8D3-2 91452 10p12.1 human S269-p 34501844 DSEVYCDsMEQFGQE molecular association, regulation VAPB(DISRUPTS) 35019937 1 2 0 -ADARB1 RED1 EC 3.5.4.37; Hydrolase; Nucleolus; RNA-binding P78563 104 21q22.3 human S211-p 23138309 GDLSLSAsPVPASLA enzymatic activity, induced 29694894 1 1 1 regulation of the steady-state levels of miR-200s; metastasis suppressor activity -PPARGC1A PGC-1 alpha Nuclear receptor co-regulator; Transcription, coactivator/corepressor Q9UBK2 10891 4p15.2 human K224-m1 1878289800 NDDPPHTkPTENRNS activity, inhibited cell growth, induced; apoptosis, inhibited 31629659 1 1 0 inhibits PGC-1a-mediated NRF1/2 activation and inhibits ROS productiion and mitochondrial biogenesis -Esrra ERR1 DNA-binding; Nuclear receptor; Transcription regulation O08580 26379 19 A|19 5.08 cM mouse S19-p 487492 YIKAEPAsPDSPKGS sumoylation transcription, inhibited 17676930; 18063693 2 22 0 induces sumoylation at ERR1-K14; increases sumoylation of ERR1 at K14 -GPSM2 GPSM2 G protein regulator, misc. P81274 29899 1p13.3 human T457-p 18412000 LKGKKYKtNSSTKVL cell cycle regulation; cell growth, altered 20589935 1 0 0 plays a critical role in cytokinesis -Llgl1 LLGL1 Cell adhesion; Cytoskeletal; Motility/polarity/chemotaxis Q80Y17 16897 11 B2|11 37.81 cM mouse S654-p 449915 GPLSRVKsLKKSLRQ intracellular localization 11809830 2 1 4 -BACE1 BACE EC 3.4.23.46; Membrane protein, integral; Protease P56817 23621 11q23.3 human K279-ac 478258 QDLKMDCkEYNYDKS Asp protein stabilization; intracellular localization 17425515 1 1 0 regulates translocation through secretory pathway -TP63 p63 DNA-binding; Transcription factor Q9H3D4 8626 3q28 human T281-p 912008300 QYVEDPItGRQSVLV P53 transcription, induced 29559659 1 0 0 Induction of LCE1C and ANXA8L1 transcription -Kif5c KIF5C P28738 16574 2 C1.1|2 28.68 cM mouse S176-p 54436200 CTERFVSsPEEVMDV Kinesin molecular association, regulation; intracellular localization 27013971 1 1 0 S176D binds poorly to microtubules, S176A binds strongly, S176A moters remained stationary 50%, 176D remainded stationary 20%, 176D diffuse in cytoplasm, S176A associated with microtubules, KIF5C transport to neurite tips -MAPK1 ERK2 EC 2.7.11.24; KINASE; Kinase, protein; Protein kinase, CMGC; Protein kinase, Ser/Thr (non-receptor) P28482 5594 22q11.22 human Y187-p 447594 HTGFLTEyVATRWYR Pkinase activity, induced; protein degradation; molecular association, regulation; intracellular localization; protein conformation; phosphorylation; enzymatic activity, induced cell differentiation, inhibited; cell cycle regulation; carcinogenesis, induced; apoptosis, altered; cell motility, induced; transcription, induced; transcription, altered; signaling pathway regulation; cell growth, induced; cell differentiation, induced; cell motility, altered; cytoskeletal reorganization; transcription, inhibited; cell growth, altered G-beta 1(INDUCES); leupaxin(NOT_REPORTED); GSK3B(INDUCES); p90RSK(INDUCES); KSR(INDUCES); NFkB-p100(DISRUPTS); ERK2(INDUCES); TACE(INDUCES) 10597231; 10925301; 11352917; 12609989; 12808105; 15004239; 15059947; 16149052; 16397900; 17562849; 17667937; 17685427; 18042541; 18045996; 18519681; 18658095; 18775330; 19060905; 19088846; 19106095; 19144315; 20122898; 20231899; 20868520; 21478863; 21530327; 21561860; 21685939; 21726627; 21730054; 21893193; 21917714; 21980390; 22385658; 23644655; 25538243; 25730857; 26079947; 26686085; 27323830; 28574827; 30987999; 31722981; 31736979; 31964804; 33667549; 34017102; 34226680; 36289618; 9124279 1163 158 4003 autoamplifcation of NFAT-c1, which promotes osteoclast differentiation, suppressed by MLN4924 -Brsk2 BRSK2 EC 2.7.11.1; EC 2.7.11.26; KINASE; Kinase, protein; Protein kinase, CAMK; Protein kinase, Ser/Thr (non-receptor) Q69Z98 75770 7|7 F5 mouse T175-p 456031 VGDSLLEtSCGSPHY Pkinase intracellular localization; enzymatic activity, induced cytoskeletal reorganization BRSK1(INDUCES); Tau(INDUCES) 17482548; 29698519 5 1 1 activation of Sad kinases in the axon during development; Sad kinases are required for the survival of cortical neurons; LKB1 phosphorylates Brsk1 and Brsk2.; Tau S262 is phosphoryated by LKB1 only in the presence of BRSK2. -RBL2 Rb-like 2 Transcription, coactivator/corepressor; Tumor suppressor Q08999 5934 16q12.2 human S952-p 449732 DSRSHQNsPTELNKD RB_B molecular association, regulation cell cycle regulation E2F4(DISRUPTS) 11157749 3 15 1 -Cacna1b CACNA1B Channel, calcium; Membrane protein, integral; Membrane protein, multi-pass Q02294 257648 3p13 rat S2016-p 25792205 TQPAPNAsPMKRSIS protein conformation RIMS1(INDUCES) 22920258 1 1 0 Calcium influx is increased due to open channel probability, facilitating neurotransmitter release by increasing number of docked vesicles at synaptic cleft. -PI4KB PIK4CB iso2 Carbohydrate Metabolism - inositol phosphate; EC 2.7.1.67; Kinase, lipid; Motility/polarity/chemotaxis Q9UBF8-2 5298 1q21.3 human S496-p 457623 GDIRRRLsEQLAHTP intracellular localization 16606619 1 56 12 S496-phosphorylated PIK4CB localizes in the nucleus -Oprm1 MOR-1 GPCR, family 1; Membrane protein, integral; Membrane protein, multi-pass; Receptor, GPCR P33535 25601 1q11 rat S266-p 447782 LKSVRMLsGSKEKDR 7tm_1 receptor desensitization, altered 10908300; 9326307 3 0 2 -NKX3-1 NKX3-1 DNA-binding; Transcription factor; Tumor suppressor Q99801 4824 8p21.2 human S48-p 3078000 RQGGRTSsQRQRDPE molecular association, regulation DNA(DISRUPTS) 11980664 1 0 0 -Stmn1 STMN1 Cytoskeletal P54227 16765 4 D3|4 66.76 cM mouse S25-p 448555 QAFELILsPRSKESV Stathmin protein stabilization carcinogenesis, induced; cell motility, induced; cell growth, induced; apoptosis, induced; cytoskeletal reorganization; signaling pathway regulation 21646391; 22698694; 36484700 52 122 91 -Kif23 KIF23 Microtubule-binding; Motility/polarity/chemotaxis; Motor E9Q5G3 71819 9|9 B mouse S904-p 459840 TGSRKRRsSTLAPAQ intracellular localization cell cycle regulation; cytoskeletal reorganization 15199097 5 18 267 regulates cytokinesis -FANCD2 FANCD2 DNA repair, damage Q9BXW9 2177 3p25.3 human T608-p 470036 NLSDEQCtQVTSLLQ FancD2 activity, induced; molecular association, regulation; ubiquitination; intracellular localization signaling pathway regulation DNA(INDUCES) 37392383 2 1 0 regulates the FA pathway -SPRED2 SPRED2 Motility/polarity/chemotaxis; Vesicle Q7Z698 200734 2p14 human Y228-p 471403 EKIWMTGyEDYRHAP protein degradation 17094949 1 0 1 Pervanadate induced Spred-2 degredation in ME4405 cells which is dependent on ubiquitination. -Pdx1 PDX1 DNA-binding; Transcription factor P52946 18609 5 G3|5 86.84 cM mouse S232-p 13421406 EQDCAVTsGEELLAV transcription, inhibited 20339896 1 0 0 -PTPN22 PTPN22 EC 3.1.3.48; Motility/polarity/chemotaxis; PHOSPHATASE; Protein phosphatase, tyrosine (non-receptor) Q9Y2R2 26191 1p13.2 human S35-p 1725300 FLKLKRQsTKYKADK enzymatic activity, inhibited; protein conformation 18056643 1 0 0 I-C11 compound inhibits phosphatase activity of PTPN22 -Ulk1 ULK1 Autophagy; EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, Other; Protein kinase, Ser/Thr (non-receptor) O70405 22241 5|5 F mouse S777-p 4699310 TRMFSVGsSSSLGST autophagy, induced 21258367 1 2 0 -UVRAG UVRAG Autophagy Q9P2Y5 7405 11q13.5 human S522-p 471489 QYKTPPPsYNSALAQ molecular association, regulation carcinogenesis, induced; cell growth, induced; autophagy, inhibited; signaling pathway regulation SMURF1(DISRUPTS); RUBCNL(INDUCES) 30686098 2 3 1 inhibits Smurf1-mediated ubiquitination at K517 and K559 -PRKCQ PKCT EC 2.7.11.13; KINASE; Kinase, protein; Protein kinase, AGC; Protein kinase, Ser/Thr (non-receptor) Q04759 5588 10p15.1 human S695-p 447906 QNMFRNFsFMNPGME Pkinase_C protein stabilization; molecular association, regulation; enzymatic activity, induced PDK1(INDUCES) 11772397; 15364937; 16252004 5 28 49 assayed in vitro -Cebpb C/EBP-beta DNA-binding; Motility/polarity/chemotaxis; Transcription factor P28033 12608 2 H3|2 87.58 cM mouse T188-p 447878 SSSSPPGtPSPADAK activity, induced; molecular association, regulation; protein conformation; phosphorylation cell growth, inhibited; cell differentiation, induced; transcription, induced; transcription, inhibited; signaling pathway regulation; transcription, altered; cell growth, altered ERK2(INDUCES); MED1(INDUCES); C/EBP-beta(INDUCES) DNA(INDUCES) 11756662; 15367685; 15985551; 17264204; 17601773; 18339625; 19244213; 19478079; 21804532; 21847090; 26114754 33 11 14 activates G-CSF promoter; induces muscle mass loss; the 3'UTRC/EBP-beta alters target gene speci?city -SUPT5H SPT5 RNA-binding; Transcription, coactivator/corepressor O00267 6829 19q13.2 human T791-p 458817 TPMYGSQtPLQDGSR transcription, altered 16427012 2 10 90 required for c-fos induction and activation in vivo -Prkar2a PKAR2A Protein kinase, regulatory subunit P12368 29699 8q32 rat S97-p 458326 SKFTRRVsVCAETFN molecular association, regulation; phosphorylation PKACA(DISRUPTS) 18550536 7 77 179 regulates PKA-dependent substrate phosphorylation and calcium signaling in cardiac cells -HBEGF HBEGF Cell surface; Membrane protein, integral Q99075 1839 5q31.3 human S207-p 2872001 VKLGMTNsH______ cell growth, altered 16557002 1 0 0 -Sgk3 SGK3 EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, AGC; Protein kinase, Ser/Thr (non-receptor) Q9ERE3 170755 1 A2|1 2.08 cM mouse S486-p 448196 DDAFVGFsYAPPSED Pkinase_C enzymatic activity, induced cell differentiation, altered; cell growth, altered 15871460 5 0 0 S486 site is indispensible for kinase activation. -TYMS TYMS Cofactor and Vitamin Metabolism - one carbon pool by folate; DNA repair, damage; EC 2.1.1.45; METHYLTRANSFERASE; Methyltransferase; Mitochondrial; Nucleotide Metabolism - pyrimidine P04818 7298 18p11.32 human T306-gl 1875343300 EGYNPHPtIKMEMAV Thymidylat_synt protein stabilization; phosphorylation TYMS(INDUCES) 34845374 1 1 0 dimer stabilization by intra- and inter-monomer interactions; reciprocal phosphorylation/O-GlcNAcylation with T306 O-GlcAc site -Stk4 MST1 Autophagy; EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, STE; Protein kinase, Ser/Thr (non-receptor) Q9JI11 58231 2|2 H3 mouse T387-p 450050 TMKRRDEtMQPAKPS enzymatic activity, induced cell adhesion, altered 12223493 6 2 7 -NFATC1 NFAT2 DNA-binding; Transcription factor O95644 4772 18q23 human S409-p 63036600 LSPTSYMsPTLPALD protein stabilization 28235034 1 0 0 -Rcan1 RCAN1 Inhibitor Q9JHG6 54720 16 C4|16 53.6 cM mouse S165-p 456023 FLISPPAsPPVGWKQ Calcipressin molecular association, regulation PPP3CA(DISRUPTS) 22864830 7 38 6 -HMMR HMMR Receptor, misc. O75330 3161 5q34 human T703-p 460367 KENFALKtPLKEGNT HMMR_C intracellular localization 28993511 1 10 6 nuclear localization -TP63 p63 iso2 DNA-binding; Transcription factor Q9H3D4-2 8626 3q28 human S358-p 1875424900 HLLQKQTsIQSPSSY molecular association, regulation DNA(INDUCES) 34761935 0 1 0 -CLOCK CLOCK ACETYLTRANSFERASE; Acetyltransferase; DNA-binding; EC 2.3.1.48; Transcription factor O15516 9575 4q12 human K67-sm 27992507 MLPGNARkMDKSTVL HLH molecular association, regulation cell cycle regulation; cell growth, induced; transcription, induced; signaling pathway regulation ER-alpha(INDUCES) 23160374 1 0 0 induces ER-alpha signaling -Map3k5 ASK1 EC 2.7.11.25; KINASE; Kinase, protein; Protein kinase, STE; Protein kinase, Ser/Thr (non-receptor) O35099 26408 10|10 A3 mouse S1040-p 451423 EDHSAPPsPEEKDSG enzymatic activity, inhibited; phosphorylation 35438255 2 32 0 inhibits p38 phosphorylation -Mapk8 JNK1 EC 2.7.11.24; KINASE; Kinase, protein; Protein kinase, CMGC; Protein kinase, Ser/Thr (non-receptor) Q91Y86 26419 14|14 B mouse Y185-p 447645 TSFMMTPyVVTRYYR Pkinase protein degradation; acetylation; molecular association, regulation; enzymatic activity, induced cell cycle regulation; carcinogenesis, induced; carcinogenesis, inhibited; cell growth, inhibited; apoptosis, induced; cell motility, induced; cell motility, inhibited; transcription, induced; signaling pathway regulation; transcription, altered; cell growth, induced; apoptosis, inhibited; transcription, inhibited p300(INDUCES); GSK3B(INDUCES); CTNNB1(INDUCES); PCAF(INDUCES) 18032450; 18952597; 21887248; 26306048; 34914791; 34962918; 35370650; 35637461; 36070687; 36310322 270 48 1269 -WEE1 Wee1 EC 2.7.10.2; KINASE; Kinase, protein; Protein kinase, Other; Protein kinase, Ser/Thr (non-receptor); Protein kinase, tyrosine (non-receptor) P30291 7465 11p15.4 human S211-p 25316773 SSVKLRGsSLFMDTE protein degradation; molecular association, regulation BTRC(INDUCES) 24817118 1 1 1 -ROCK1 ROCK1 EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, AGC; Protein kinase, Ser/Thr (non-receptor) Q13464 6093 18q11.1 human S1341-p 1216639 TRSTANQsFRKVVKN intracellular localization cytoskeletal reorganization 21685893 2 14 32 inhibits apical constriction -Slc12a5 KCC2 iso2 Membrane protein, integral; Membrane protein, multi-pass; Transporter; Transporter, SLC family Q63633-2 171373 3q42 rat S937-p 2025121 IQSITDEsRGSIRRK SLC12 activity, induced; protein conformation 24849604 3 2 0 increase transport kinetics of KCC2 -PTRH2 PTRH2 EC 3.1.1.29; Hydrolase; Mitochondrial Q9Y3E5 51651 17q23.1 human S87-p 4206800 GKVAAQCsHAAVSAY PTH2 apoptosis, altered; cell adhesion, altered 18703509 1 0 0 associated with anoikis (cell death induced by detachment from the extracellular matrix) -GJA1 GJA1 Channel, misc.; Membrane protein, integral; Membrane protein, multi-pass; Motility/polarity/chemotaxis P17302 2697 6q22.31 human Y313-p 454254 SEQNWANySAEQNRM Connexin43 molecular association, regulation; intracellular localization DBN1(DISRUPTS) 30448479 5 20 298 -LZTS2 LZTS2 Nuclear export Q9BRK4 84445 10q24.31 human S277-p 1871717500 HSDSGRSsSSKSTGS protein degradation; molecular association, regulation; ubiquitination; phosphorylation carcinogenesis, induced; cell motility, induced; cell growth, induced; signaling pathway regulation BTRC(INDUCES) 33420362 1 0 0 induces phosphorylation of downstream targets thus inducing the PI3K/AKT signaling pathway -SSTR2 SSTR2 GPCR, family 1; Membrane protein, integral; Membrane protein, multi-pass; Receptor, GPCR P30874 6752 17q25.1 human S343-p 7652105 DDGERSDsKQDKSRL receptor desensitization, induced; receptor internalization, induced; receptor recycling, induced; receptor internalization, altered 21330405; 21343287; 22538189; 24565897; 24637622; 25012983 10 0 0 -CDC42BPA MRCKA EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, AGC; Protein kinase, Ser/Thr (non-receptor) Q5VT25 8476 1q42.13 human S234-p 12612500 MEDGTVQsSVAVGTP Pkinase enzymatic activity, induced cytoskeletal reorganization 11283256 1 0 0 -YAP1 YAP1 Oncoprotein; Transcription, coactivator/corepressor P46937 10413 11q22.1 human T143-p 3190678 AVSPGTLtPTGVVSG protein stabilization; ubiquitination; intracellular localization cell cycle regulation; cell motility, induced 26933062; 35705994 2 6 51 mitotic shift, important for proper mitosis and cytokinesis ; inhibits ubiquitination -DRD1 DRD1 GPCR, family 1; Membrane protein, integral; Membrane protein, multi-pass; Receptor, GPCR P21728 1812 5q35.2 human T245-p 1869357205 AKNCQTTtGNGKPVE 7tm_1 molecular association, regulation ARR3(INDUCES) 32503917 1 0 0 -JUNB JunB Motility/polarity/chemotaxis; Oncoprotein; Transcription factor P17275 3726 19p13.13 human T104-p 1814000 GVITTTPtPPGQYFY Jun activity, induced; molecular association, regulation transcription, altered DNA(INDUCES) 9889198 1 8 2 Phosphorylation of JunB increases cooperative binding with c-Maf to DNA. -IGF2BP1 IGF2BP1 RNA-binding; Translation Q9NZI8 10642 17q21.32 human Y396-p 458348 SVTGAAPySSFMQAP intracellular localization carcinogenesis, inhibited; apoptosis, induced; RNA stability, inhibited; translation, induced 33388443 6 0 0 -FAF1 FAF1 Apoptosis; Nuclear receptor co-regulator Q9UNN5 11124 1p32.3 human S582-p 480070 KLRIRTPsGEFLERR UBX molecular association, regulation; intracellular localization TGFBR3(DISRUPTS); BTRC(DISRUPTS); VCP(DISRUPTS) 28443643 1 37 218 inhibits membrane localization -PER2 PER2 Nuclear receptor co-regulator; Nucleolus; Transcription factor O15055 8864 2q37.3 human S480-p 50596800 PVPHSGSsGYGSLGS protein degradation; molecular association, regulation BTRC(INDUCES) 30425162 4 0 0 -NHERF1 NHERF Adaptor/scaffold; Motility/polarity/chemotaxis O14745 9368 17q25.1 human S290-p 450313 PALVRSAsSDTSEEL EBP50_C molecular association, regulation; protein conformation SLC34A1(INDUCES) 30696771 5 55 96 regulates phosphate uptake by SLC34A1 -MAPRE1 EB1 Cytoskeletal; Motility/polarity/chemotaxis Q15691 22919 20q11.21 human S155-p 476322 KPKKPLTsSSAAPQR intracellular localization carcinogenesis, induced; carcinogenesis, inhibited; cell motility, induced; cell motility, inhibited; signaling pathway regulation; cell growth, induced; apoptosis, inhibited; cytoskeletal reorganization 24930764; 30250248 2 11 0 enhances cytotoxicity -HSP90AB1 HSP90B Chaperone; Heat shock protein P08238 3326 6p21.1 human S226-p 454114 KEREKEIsDDEAEEE HSP90 activity, induced; molecular association, regulation; protein processing; intracellular localization; protein conformation apoptosis, altered; apoptosis, induced HSP40(DISRUPTS); AHSA1(DISRUPTS); PXR(INDUCES); APAF(DISRUPTS); CACYBP(INDUCES); DNAJC7(DISRUPTS); HSC70(DISRUPTS); CDC37(DISRUPTS); GR(DISRUPTS) 18591256; 25995454; 29854279; 34359868 8 93 101 induced by triptolide -TNS3 tensin 3 Adaptor/scaffold; Motility/polarity/chemotaxis Q68CZ2 64759 7p12.3 human Y1173-p 9824600 QDTSKFWyKADISRE SH2 molecular association, regulation cell motility, altered; cell growth, altered P130Cas(INDUCES); KHDRBS1(INDUCES); FAK(INDUCES) 19732724 1 0 0 contributes to tumorigenesis and metastasis -HSPA1A HSP70 Chaperone; Heat shock protein; Motility/polarity/chemotaxis P0DMV8 3303 6p21.33 human R447-me 1877047300 IQVYEGErAMTKDNN HSP70 protein stabilization carcinogenesis, induced; cell growth, induced; apoptosis, inhibited RNA(INDUCES) 32699135 1 1 0 binding and stabilization of BCL2 mRNA -mos MOS EC 2.7.11.1; KINASE; Kinase, protein; Oncoprotein; Protein kinase, Other; Protein kinase, Ser/Thr (non-receptor) P12965 397924 frog S3-p 448658 _____MPsPIPVERF protein stabilization; enzymatic activity, induced 12426378; 16809767 3 1 0 necessary for oocyte maturation and the spindle assembly checkpoint; in Xenopus oocytes, not cell lines -PCLAF PAF DNA repair, damage Q15004 9768 15q22.31 human K15-ub 12327204 SVPGTYRkVVAARAP PAF DNA repair, altered 23000965 1 1 7 -ZAP70 ZAP70 EC 2.7.10.2; KINASE; Kinase, protein; Protein kinase, TK; Protein kinase, tyrosine (non-receptor) P43403 7535 2q11.2 human Y597-p 464391 EQRMRACyYSLASKV enzymatic activity, altered transcription, altered 9624129 1 1 193 -VCP VCP Chaperone; DNA repair, damage; EC 3.6.4.6; Endoplasmic reticulum; Hydrolase P55072 7415 9p13.3 human K315-m3 15381938 AIAPKREkTHGEVER AAA enzymatic activity, inhibited 23349634 5 6 2 inhibits ATPase activity -MAP3K14 Nik EC 2.7.11.25; KINASE; Kinase, protein; Protein kinase, STE; Protein kinase, Ser/Thr (non-receptor) Q99558 9020 17q21.31 human S814-p 27259014 DDSEKNPsKASQSSR protein degradation 20501937 2 1 0 IKKA-dependent destabilization of Nik -Tnik TNIK EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, STE; Protein kinase, Ser/Thr (non-receptor) D3ZZQ0 294917 2q24 rat T187-p 480117 RTVGRRNtFIGTPYW Pkinase enzymatic activity, induced 26645429 1 7 76 -ATG4B ATG4B Autophagy; EC 3.4.22.-; Protease; Ubiquitin conjugating system Q9Y4P1 23192 2q37.3 human S383-p 470896 RLERFFDsEDEDFEI ATG4_LIR molecular association, regulation; enzymatic activity, induced carcinogenesis, induced; autophagy, induced; cell growth, induced LC3A(INDUCES) 26378241; 29232556 3 37 2 -TUBA1A TUBA1A Cytoskeletal; Motility/polarity/chemotaxis P81947 404053 cow Y103-p 6835001 KEDAANNyARGHYTI Tubulin cytoskeletal reorganization 19631231 0 13 530 -PLK1 PLK1 EC 2.7.11.21; KINASE; Kinase, protein; Protein kinase, Other; Protein kinase, Ser/Thr (non-receptor) P53350 5347 16p12.2 human K209-me 1877571000 EYDGERKkTLCGTPN Pkinase enzymatic activity, inhibited cell cycle regulation; cell growth, inhibited 30622182 1 1 0 -Cox5b COX5B EC 1.9.3.1; Energy Metabolism - oxidative phosphorylation; Mitochondrial; Oxidoreductase P19536 12859 1|1 B mouse S70-p 476779 MLPPKAAsGTKEDPN COX5B enzymatic activity, inhibited 24130844 2 1 0 S70A mutant showed a reduced loss of activity under hypoxic conditions. -BUB1B BUB1B EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, Other; Protein kinase, Ser/Thr (non-receptor); Tumor suppressor O60566 701 15q15.1 human T792-p 7652106 PRNSAELtVIKVSSQ enzymatic activity, induced cell cycle regulation 17376779 2 0 0 facilitates chromosome alignment during prometaphase -Cavin1 PTRF Transcription initiation complex O54724 19285 11 D|11 63.95 cM mouse T304-p 2566127 DKLRKSFtPDHVVYA PTRF_SDPR phosphorylation 21282370 2 30 7 regulates phosphorylation of HSL S557 (aka S563) and S651 (aka S660); regulates lipolysis in adipocytes -POLH POLH DNA repair, damage; EC 2.7.7.7; Transferase Q9Y253 5429 6p21.1 human K533-sm 1877365919 TGTEPFFkQKSLLLK intracellular localization; enzymatic activity, inhibited 32350109 1 1 0 -CNTROB LIP8 Cell cycle regulation Q8N137 116840 17p13.1 human S36-p 27565611 QVSSEVTsQLYASLR cell motility, inhibited 23291182 1 0 0 -Cacna1d CACNA1D Channel, calcium; Membrane protein, integral; Membrane protein, multi-pass P27732 29716 16p16 rat S81-p 470135 PPPVGSLsQRKRQQY activity, inhibited 16973824 1 1 1 -SYK Syk EC 2.7.10.2; KINASE; Kinase, protein; Protein kinase, TK; Protein kinase, tyrosine (non-receptor) P43405 6850 9q22.2 human Y352-p 447660 TEVYESPyADPEEIR molecular association, regulation; enzymatic activity, induced CLTC(INDUCES); ITGAM(INDUCES); PLCG1(INDUCES) 18818202; 19289168; 8657103 38 22 248 -AMBRA1 AMBRA1 Autophagy; UBIQUITIN LIGASE; Ubiquitin ligase; Vesicle Q9C0C7 55626 11p11.2 human S52-p 27443426 KRVELPDsPRSTFLL protein degradation; ubiquitination; enzymatic activity, inhibited; activity, inhibited autophagy, inhibited; signaling pathway regulation 23524951; 36476874 4 4 0 -POLL POLL DNA repair, damage; EC 2.7.7.7; Lyase; Transferase Q9UGP5 27343 10q24.32 human K27-p 1876957802 ASSKVLAkIPRREEG intracellular localization DNA repair, induced 32224012 1 0 0 SUMOylation of PolL in response to DNA damage -PRKDC DNAPK DNA repair, damage; EC 2.7.11.1; KINASE; Kinase, protein; Nucleolus; Protein kinase, Ser/Thr (non-receptor); Protein kinase, atypical P78527 5591 8q11.21 human S2023-p 33365500 NGDSDGPsYMSSLSY DNAPKcs_CC3 molecular association, regulation DNA repair, inhibited DNA(INDUCES) 24687855 1 0 0 induces c-NHEJ, restricts end processing -HTT Huntingtin Cytoskeletal P42858 3064 4p16.3 human S114-p 13261664 CENIVAQsVRNSPEF apoptosis, induced 24505464 1 2 0 -Des desmin Cytoskeletal; Motility/polarity/chemotaxis P31001 13346 1 C4|1 38.85 cM mouse S32-p 466343 SLGSPLSsPVFPRAG Filament_head cell cycle regulation 27565725 4 13 31 -APBB1IP RIAM Adaptor/scaffold; Motility/polarity/chemotaxis Q7Z5R6 54518 10p12.1 human Y45-p 462981 PPRAEFNySVGFKDL activity, induced; intracellular localization; protein conformation signaling pathway regulation; cell adhesion, inhibited 30733287 1 0 73 autoinhibited by an intramolecular association, inhibits T cell adhesion -Nkx3-2 NKX3-2 Cell development/differentiation; DNA-binding; Transcription factor P97503 12020 5 B3|5 22.58 cM mouse K260-ub 1593379700 WFQNRRYkTKRRQMA Homeodomain molecular association, regulation apoptosis, inhibited IKKG(INDUCES) 21606193 1 1 0 ubiquitination-dependent interaction with IKKG (aka NEMO) promotes formation of the complex NKX3.2-IKKG(NEMO)-IKKB -Rfc1 RFC1 DNA replication D3ZFT1 89809 14p11 rat T110-p 468618 PVTYISEtDEDDDFL intracellular localization transcription, inhibited 10625661 1 35 26 -Camk2b CAMK2B EC 2.7.11.17; KINASE; Kinase, protein; Protein kinase, CAMK; Protein kinase, Ser/Thr (non-receptor) P08413 24245 14q21 rat T333-p 48915801 MSTAASGtTMGLVEQ molecular association, regulation 26291163 1 1 0 inhibits interaction with F-actin, regulates synaptic plasticity -MDC1 MDC1 Cell cycle regulation Q14676 9656 6p21.33 human T301-p 477987 PPGEDSDtDVDDDSR molecular association, regulation cell cycle regulation NBS1(INDUCES) 18678890 1 24 21 MDC1-NBS1 interaction regulates intra-S-phase checkpoint activation -Nr3c1 GR DNA-binding; Mitochondrial; Nuclear receptor; Transcription factor P06537 14815 18 B3|18 21.09 cM mouse S284-p 3178938 TGDTILSsPSSVALP GCR neural plasticity 35733193 3 13 0 -Smarca2 SMARCA2 EC 3.6.1.-; EC 3.6.4.-; Helicase; Nuclear receptor co-regulator; Transcription, coactivator/corepressor Q6DIC0 67155 19 C1|19 21.17 cM mouse K1549-ac 460623 KKRPNRGkAKPVVSD molecular association, regulation; protein conformation cell growth, induced; transcription, inhibited Rb(DISRUPTS) DNA(DISRUPTS) 14657023 1 0 0 -POLR2A POLR2A EC 2.7.7.48; EC 2.7.7.6; Nucleotide Metabolism - purine; Nucleotide Metabolism - pyrimidine; Transcription initiation complex; Transferase P24928 5430 17p13.1 human S1619-p 447616 SPSYSPTsPSYSPTS RNA_pol_Rpb1_R protein degradation; molecular association, regulation; intracellular localization; enzymatic activity, inhibited; enzymatic activity, induced apoptosis, induced; transcription, induced; transcription, altered; transcription, inhibited CTDSP1(INDUCES); CABIN1(INDUCES); UBN1(INDUCES); HIRA(INDUCES) DNA(INDUCES) 10886368; 10995388; 11425311; 16641292; 17157258; 17259211; 18066052; 18079403; 19901026; 20434984; 20880846; 21159777; 22195966; 25023704; 25561469; 25620562; 26588990; 27099314; 34608337 81 4 0 binds viral RNP and Influenza A virus polymerase; PRC1 mediated repression is achieved by controlling transcriptional burst frequency; controls APA control region in the nervous system and regulates neuronal development -Ppargc1a PGC-1 alpha Nuclear receptor co-regulator; Transcription, coactivator/corepressor O70343 19017 5|5 C1 mouse S570-p 2045307 RMRSRSRsFSRHRSC molecular association, regulation transcription, inhibited; signaling pathway regulation DNA(DISRUPTS) 17554339 4 0 0 regulates decrease glucose production and regulates beta oxidation of fatty acids through Akt/PGC-1 alpha pathway -Jak2 JAK2 EC 2.7.10.2; KINASE; Kinase, protein; Oncoprotein; Protein kinase, TK; Protein kinase, tyrosine (non-receptor) Q62689 24514 1q52 rat Y1007-p 448407 VLPQDKEyYKVKEPG PK_Tyr_Ser-Thr enzymatic activity, induced 15065871 80 5 15 -PKM PKM Carbohydrate Metabolism - glycolysis and gluconeogenesis; Carbohydrate Metabolism - pyruvate; EC 2.7.1.40; KINASE; Kinase, other; Mitochondrial; Nucleotide Metabolism - purine P14618 5315 15q23 human K270-sm 55435842 KNIKIISkIENHEGV PK intracellular localization; enzymatic activity, inhibited cell differentiation, inhibited PKM(INDUCES); AML1(INDUCES) 33473116 1 2 0 Sumoylation dissembled the tetrameric PKM2 to dimers in vitro and in leukemia cells (size-exclusion chromatography). induces nuclear localization, block of myeloid differentiation -Nol3 ARC Apoptosis; Nucleolus Q62881 85383 19q11 rat T149-p 448618 SEAVQPRtPEEPELE molecular association, regulation; intracellular localization; activity, inhibited apoptosis, inhibited CASP2(INDUCES) 12191471; 16639714; 19001025; 24106598 5 6 0 protects cells against oxidative stress; inhibition of hypertrophy; T149 phosphorylation promotes ARC localization to mitochondria, allowing ARC binding to Caspase-8.; T149D mutant inhibits apoptosis induced by isoproterenol or aldosterone -CLDN2 Claudin-2 Cytoskeletal; Membrane protein, integral; Membrane protein, multi-pass P57739 9075 Xq22.3 human Y224-p 462035 VKSEFNSySLTGYV_ molecular association, regulation ZO1(DISRUPTS) 26023235 1 0 3 disruption of barrier function -VCP VCP Chaperone; DNA repair, damage; EC 3.6.4.6; Endoplasmic reticulum; Hydrolase P55072 7415 9p13.3 human T509-p 4271173 KFLKFGMtPSKGVLF molecular association, regulation; intracellular localization; phosphorylation cell cycle regulation OTUB1(INDUCES); CLN3(INDUCES) 29950310 1 11 8 Cdc48 in the stabilization of Cln3 in the nucleus, regulates G1-cyclin activity for cell cycle entry, enhanced pRB phosphorylation -FGF10 FGF10 Cell development/differentiation; Cytokine; Motility/polarity/chemotaxis; Secreted; Secreted, signal peptide O15520 2255 5p12 human T114-p 12063900 PYSILEItSVEIGVV FGF activity, induced; molecular association, regulation cell growth, altered FGFR2(NOT_REPORTED) 20036575 1 0 0 -CD1D CD1D Apoptosis; Cell surface; Lipid-binding; Membrane protein, integral P15813 912 1q23.1 human T322-p 14364502 FLLIVGFtSRFKRQT TM protein degradation; intracellular localization 20368272; 23710894 2 0 1 inhibits cell surface expression and antigen presentation; regulates CD1D targeting to lysosomes -CD44 CD44 Cell adhesion; Membrane protein, integral; Motility/polarity/chemotaxis; Receptor, misc. P16070 960 11p13 human S672-p 455524 AVCIAVNsRRRCGQK molecular association, regulation cytoskeletal reorganization Ezrin(INDUCES) 12032545 5 0 0 -NFKB2 NFkB-p100 DNA-binding; Oncoprotein; Transcription factor Q00653 4791 10q24.32 human S707-p 20804978 EPLCPLPsPPTSDSD protein degradation; molecular association, regulation; ubiquitination carcinogenesis, induced; cell growth, induced; apoptosis, inhibited; transcription, induced FBXW7(INDUCES) 22388891; 22864569 2 2 0 -RAD51 RAD51 DNA repair, damage; Mitochondrial Q06609 5888 15q15.1 human K156-ac 1873284314 DRGGGEGkAMYIDTE Rad51 DNA repair, inhibited 28869605 1 0 0 -ATF6 ATF6A Membrane protein, integral; Transcription factor P18850 22926 1q23.3 human K152-ub 1881440801 AEPLKEDkPVTGPRN signaling pathway regulation 34623328 1 0 0 K152 ATF6 is required for PRR-induced, RNF186-dependent antimicrobial pathways in human MDMs -SAMHD1 SAMHD1 EC 3.1.4.- Q9Y3Z3 25939 20q11.23 human T592-p 468674 DVIAPLItPQKKEWN molecular association, regulation; intracellular localization; enzymatic activity, inhibited; protein conformation; enzymatic activity, induced cell cycle regulation; cell growth, inhibited SAMHD1(DISRUPTS) DNA(INDUCES) 28956603; 34321470; 34379507; 34513928; 35801923; 37127613 22 61 5 -PACS2 PACS2 Q86VP3 23241 14q32.33 human S437-p 480160 GRRGRSTsLKERQAA chromatin organization, altered 23852728 1 2 8 mitochondria-associated ER membrane integrity -INSR INSR EC 2.7.10.1; KINASE; Kinase, protein; Membrane protein, integral; Protein kinase, TK; Protein kinase, tyrosine (receptor) P06213 3643 19p13.2 human Y1011-p 449048 DVFPCSVyVPDEWEV enzymatic activity, inhibited 12707268 5 0 2 -SPEN SHARP Nuclear receptor co-regulator; RNA-binding; Spliceosome; Transcription factor Q96T58 23013 1p36.21-p36.13 human S3486-p 455623 QPAPKQDsSPHLTSQ transcription, altered 15824732 1 2 0 -Usf1 USF1 DNA-binding; Transcription factor Q61069 22278 1 H3|1 79.4 cM mouse S309-p 40515061 EVVIKNDsN______ molecular association, regulation transcription, inhibited DNA(DISRUPTS) 36534975 1 5 0 -SIK2 QIK EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, CAMK; Protein kinase, Ser/Thr (non-receptor) Q9H0K1 23235 11q23.1 human S343-p 2150903 RLKSHRSsFPVEQRL enzymatic activity, induced 27478041 3 6 4 -FUS hnRNP P2 DNA-binding; Nuclear receptor co-regulator; Oncoprotein; RNA splicing; RNA-binding; SUMO LIGASE P35637 2521 16p11.2 human R514-me 1873356110 GPGKMDSrGEHRQDR intracellular localization KPNB2(DISRUPTS) 22968170 1 0 0 Arginines in the RGG3 domain are required for nuclear import of mutant hnRNP, and arginine methylation in this domain reduces KPNB2 binding. -Zic2 ZIC2 C2H2-type zinc finger protein; DNA-binding Q62520 22772 14 E5|14 65.97 cM mouse S200-p 1783002 EQYRQVAsPRTDPYS activity, induced; molecular association, regulation transcription, altered DDX9(INDUCES) 18068128 1 1 0 -Stmn1 STMN1 Cytoskeletal P54227 16765 4 D3|4 66.76 cM mouse S16-p 448554 KELEKRAsGQAFELI Stathmin protein stabilization carcinogenesis, induced; cell motility, induced; cell growth, induced; apoptosis, induced; cytoskeletal reorganization; signaling pathway regulation 21646391; 32251425; 36484700 38 98 61 -PCLAF PAF DNA repair, damage Q15004 9768 15q22.31 human K24-ub 9187086 VAARAPRkVLGSSTS PAF DNA repair, altered 23000965 1 12 112 -CBX4 CBX4 EC 6.3.2.-; SUMO LIGASE; SUMO conjugating system; SUMO ligase; Transcription, coactivator/corepressor O00257 8535 17q25.3 human K280-ub 573756668 GMQAVKIkSGEVAEG protein degradation 32111827 1 1 0 -RAPH1 RAPH1 Adaptor/scaffold; Motility/polarity/chemotaxis Q70E73 65059 2q33.2 human S1066-p 23137493 DSVVEFPsPPSDSDF intracellular localization cell motility, induced VASP(DISRUPTS) 37632751 1 1 1 regulates MENA localization -PPP1R14B PPP1R14B Inhibitor; Protein phosphatase, regulatory subunit Q96C90 26472 11q13.1 human T57-p 1904503 VRRQGKVtVKYDRKE PP1_inhibitor activity, induced; activity, inhibited cell motility, altered 10606530; 12144526 4 4 1 inhibition of MLCP activity, activates contractile response in arterial smooth muscle; required for full inhibition of PP1CA in vitro. -RUBCNL RUBCNL Q9H714 80183 13q14.13 human S157-p 25284922 SPGILATsPYPETDS molecular association, regulation; acetylation; intracellular localization autophagy, inhibited; signaling pathway regulation VPS39(DISRUPTS); STX17(DISRUPTS); VPS41(DISRUPTS); Tip60(DISRUPTS) 30704899 1 0 1 phosphorylation of this site inhibits acetylation of RUBCNL sites K483, K523, K533, K573, K633, by inhibiting the GSK3/TIP60 signaling pathway -Eef1a1 EEF1A1 Nucleolus; Translation; Translation elongation P62630 171361 8q31 rat K165-m3 15382301 TEPPYSQkRYEEIVK GTP_EFTU molecular association, regulation translation, altered EEF1D(DISRUPTS); eEF1B(DISRUPTS); EEF1G(DISRUPTS) 28108655 1 3 3 -ANXA2 ANXA2 Calcium-binding; Lipid-binding; Motility/polarity/chemotaxis P07355 302 15q22.2 human T19-p 469172 SLEGDHStPPSAYGS intracellular localization 20597553 1 28 30 -ESPL1 separase EC 3.4.22.49; Protease Q14674 9700 12q13.13 human S1660-p 1269647504 ADQLQGLsLQEMPGD molecular association, regulation; phosphorylation cell cycle regulation; DNA repair, induced H2AX(INDUCES) 30305303 1 0 0 NES phosphorylation -TFRC TfR Cell surface; Membrane protein, integral; Receptor, misc. P02786 7037 3q29 human Y20-p 448928 FGGEPLSyTRFSLAR receptor internalization, induced endocytosis, induced; carcinogenesis, induced; cell growth, induced; apoptosis, inhibited 21859709; 35338344 2 43 1048 -Kit Kit EC 2.7.10.1; KINASE; Kinase, protein; Membrane protein, integral; Oncoprotein; Protein kinase, TK; Protein kinase, tyrosine (receptor) P05532 16590 5 C3.3|5 39.55 cM mouse Y732-p 454941 DMKPGVSyVVPTKTD PK_Tyr_Ser-Thr activity, induced; phosphorylation cell cycle regulation; cell growth, altered 11090054 1 4 28 promotes PLCg1 phosphorylation and Ca(2+) mobilization -CDK5RAP2 CDK5RAP2 Cytoskeletal Q96SN8 55755 9q33.2 human S140-p 41694200 SLAEAGGsEIQRVKE molecular association, regulation cytoskeletal reorganization TUBG1(INDUCES) 26192437 1 0 0 -MAPK15 ERK7 EC 2.7.11.24; KINASE; Kinase, protein; Protein kinase, CMGC; Protein kinase, Ser/Thr (non-receptor) Q8TD08 225689 8q24.3 human T175-p 459216 GPEDQAVtEYVATRW Pkinase enzymatic activity, induced apoptosis, induced 16336213; 16484222; 28467781 3 2 0 -Bmp4 BMP4 Secreted; Secreted, signal peptide P21275 12159 14 C1|14 23.95 cM mouse S91-p 1874396400 RDLYRLQsGEEEEEE TGFb_propeptide protein stabilization carcinogenesis, induced; cell differentiation, induced; transcription, induced 34433585 1 0 0 prevent lysosomal degradation of the protein BMP4 -Foxp3 FOXP3 C2H2-type zinc finger protein; Cell cycle regulation; DNA-binding; Transcription factor Q99JB6 20371 X A1.1|X 3.41 cM mouse S19-p 12201088 PSLALGPsPGVLPSW protein degradation cell growth, induced; transcription, altered 23853094 1 1 0 alanine mutants of S19 or T175 inhibited (lL2) or induced (CD25) transcription of FOXP3 responsive genes, suppressed T cell proliferation, and showed an anti-inflamatory effect in a murine colitis model -GLS glutaminase Amino Acid Metabolism - alanine, aspartate and glutamate; Amino Acid Metabolism - arginine and proline; EC 3.5.1.2; Energy Metabolism - nitrogen; Hydrolase; Mitochondrial; Other Amino Acids Metabolism - D-Glutamine and D-glutamate O94925 2744 2q32.2 human S95-p 36122852 THPQPGVsPPAAPAA enzymatic activity, inhibited cell growth, inhibited; cell motility, inhibited 30092248 1 3 0 decreases vimentin levels -PKD2 PKD2 Channel, cation; Membrane protein, integral; Membrane protein, multi-pass Q13563 5311 4q22.1 human S76-p 460685 AGAAASPsPPLSSCS intracellular localization 16551655 1 5 0 -Arhgef7 ARHGEF7 GEF; GEF, Rac/Rho; Motility/polarity/chemotaxis Q9ES28 54126 8|8 A1.1 mouse S682-p 455681 EEFAVRKsTAALEED RhoGEF67_u2 intracellular localization 12226077 3 19 2 -Mst1r Ron EC 2.7.10.1; KINASE; Kinase, protein; Membrane protein, integral; Protein kinase, TK; Protein kinase, tyrosine (receptor) Q62190 19882 9 59.07 cM|9 F1 mouse Y1175-p 456482 QVACGMEyLAEQKFV PK_Tyr_Ser-Thr enzymatic activity, induced Src(NOT_REPORTED) 16103119 2 0 0 this site is responsible for constitutive activation of the MAP kinase pathway -Tdg TDG DNA repair, damage; EC 3.2.2.29; Hydrolase; Nuclear receptor co-regulator P56581 21665 10 C1|10 39.72 cM mouse K98-ac 458996 ATSKKSGkSTKSKEK molecular association, regulation; acetylation; phosphorylation DNA repair, induced; chromatin organization, altered; DNA repair, inhibited; transcription, induced APE1(DISRUPTS) DNA(DISRUPTS) 11864601; 19966277 2 1 0 inhibits phosphorylation at other sites; histone acetylation -orf1ab nsp6-pp1a-pp1ab NP_828864 1489680 SARSCoV1 K61-ub 1883544401 ACAMLLVkHKHAFLC molecular association, regulation; intracellular localization TAK1(INDUCES); IKKG(INDUCES) 35856559 1 0 0 Accessory protein 7a and | nsp6-pp1a-pp1ab ubiquitiylation are required for the recruitment of NEMO and TAK1 to ORF7a and required for NF-kB activation. -Scn2a SCN2A Channel, sodium; Membrane protein, integral; Membrane protein, multi-pass P04775 24766 3q21 rat S1506-p 2999207 NAMKKLGsKKPQKPI activity, inhibited 12359152 1 0 0 -Dnmt1 DNMT1 Amino Acid Metabolism - cysteine and methionine; Cell development/differentiation; EC 2.1.1.37; METHYLTRANSFERASE; Methyltransferase; Methyltransferase, DNA; Transcription regulation P13864 13433 9 A3|9 7.66 cM mouse S515-p 458936 MQEKIYIsKIVVEFL DNMT1-RFD protein conformation; enzymatic activity, induced 17965600 2 2 0 important for an interaction between the N-terminal and the catalytic domain of DNMT1 -NFATC1 NFAT2 DNA-binding; Transcription factor O95644 4772 18q23 human S403-p 41453279 WAKPKPLsPTSYMSP protein stabilization 28235034 1 1 0 -MTMR2 MTMR2 Carbohydrate Metabolism - fructose and mannose; Cofactor and Vitamin Metabolism - riboflavin; Cofactor and Vitamin Metabolism - thiamine; EC 3.1.3.64; EC 3.1.3.95; Motility/polarity/chemotaxis; PHOSPHATASE; Phosphatase, lipid; Protein phosphatase, tyrosine (non-receptor) Q13614 8898 11q21 human S631-p 2526091 SSSERASsPAQCVTP molecular association, regulation; intracellular localization RAB5A(INDUCES); APPL(DISRUPTS) 23378027 1 12 0 inhibits binding and targting to early endosomes, regulates endosomal shuttling -PRKAA1 AMPKA1 Autophagy; EC 2.7.11.1; EC 2.7.11.26; EC 2.7.11.27; EC 2.7.11.31; KINASE; Kinase, protein; Protein kinase, CAMK; Protein kinase, Ser/Thr (non-receptor) Q13131 5562 5p13.1 human K485-ub 21128826 DDEITEAkSGTATPQ AdenylateSensor enzymatic activity, inhibited 31996460 1 5 0 -XPO1 Exportin-1 Karyopherin; Nuclear export; Nuclear import; Nucleolus O14980 7514 2p15 human S391-p 3174716 SPFSTSAsPLLSGSQ molecular association, regulation; intracellular localization cell cycle regulation; cytoskeletal reorganization RAN(INDUCES) 23729730 1 15 3 -FYB2 ARAP Adaptor/scaffold Q5VWT5 199920 1p32.2 human Y521-p 56614901 SEENRELyEDVYKTK intracellular localization signaling pathway regulation 27335501 1 0 0 -FGFR4 FGFR4 EC 2.7.10.1; KINASE; Kinase, protein; Membrane protein, integral; Protein kinase, TK; Protein kinase, tyrosine (receptor) P22455 2264 5q35.2 human Y642-p 461988 RGVHHIDyYKKTSNG PK_Tyr_Ser-Thr carcinogenesis, induced; cell growth, induced 34163030 1 9 51 -ACE2 ACE2 EC 3.4.17.23; Membrane protein, integral; Protease Q9BYF1 59272 Xp22.2 human S680-p 1868162500 ANLKPRIsFNFFVTA Collectrin protein conformation 37292255 3 0 0 induces conformational changes in all types of SARS-CoV-2 -Id1 ID1 DNA-binding; Transcription, coactivator/corepressor P20067 15901 2 H1|2 75.41 cM mouse S5-p 479430 ___MKVAsGSAAAAA intracellular localization 17412691 1 0 0 forskolin-induced nuclear localization -WWC1 KIBRA Adaptor/scaffold Q8IX03 23286 5q34 human S542-p 25673102 SPRSSLSsPSPPCSP cell cycle regulation; cell growth, induced 22784093; 24269383 2 0 0 -POLH POLH DNA repair, damage; EC 2.7.7.7; Transferase Q9Y253 5429 6p21.1 human S601-p 18330800 EMDLAHNsQSMHASS cell cycle regulation 21242293 2 1 1 influences cell survival -DOCK2 DOCK2 Adaptor/scaffold; GAP; GAP, Rac/Rho; Motility/polarity/chemotaxis Q92608 1794 5q35.1 human Y985-p 1876205000 DLIGKNVyPGDWMAM molecular association, regulation; intracellular localization; enzymatic activity, induced transcription, induced; signaling pathway regulation RAC1(INDUCES) 35079145 1 1 0 induces RAC1 GTPase recruitment and activation further inducing CLR signaling -DBF4 DBF4 Cell cycle regulation; Protein kinase, regulatory subunit Q9UBU7 10926 7q21.12 human S539-p 482262 GLITINSsQEHLTVQ cell cycle regulation 22123827 1 1 0 DBF4 phosphorylaion is important for supressing DNA replication. -GRIA4 GluR4 Channel, ligand-gated; Membrane protein, integral; Membrane protein, multi-pass P48058 2893 11q22.3 human S862-p 448810 IRNKARLsITGSVGE molecular association, regulation ACTN1(DISRUPTS) 16190873 6 4 1 Phosphorylation alters GluR4 binding to alpha-actinin in vitro and in vivo, but has no affect on IQGAP1 binding. -TOB2 TOB2 Q14106 10766 22q13.2 human S153-p 22999103 QDSSLSNsPSPSFGQ cell growth, inhibited 22252318 1 1 0 promote mRNA deadenylaion and decay and the ability to suppress proliferation -PRKCA PKCA EC 2.7.11.13; KINASE; Kinase, protein; Oncoprotein; Protein kinase, AGC; Protein kinase, Ser/Thr (non-receptor) P04409 282001 cow T638-p 448685 TRGQPVLtPPDQLVI Pkinase_C phosphorylation; enzymatic activity, induced 8805373 22 15 2 prolongs activation kinetics (not activity itself) and protection from phosphatases -CDC25A CDC25A EC 3.1.3.48; Motility/polarity/chemotaxis; PHOSPHATASE; Protein phosphatase, dual-specificity P30304 993 3p21.31 human S156-p 1874397800 KKPVRPVsRGCLHSH M-inducer_phosp protein degradation; ubiquitination cell cycle regulation; apoptosis, inhibited 34363019 1 1 0 -MYOD1 MyoD DNA-binding; RNA splicing; Transcription factor P15172 4654 11p15.1 human K104-ac 459081 ACKACKRkTTNADRR Basic molecular association, regulation; protein conformation cell differentiation, induced; transcription, induced DNA(INDUCES) 10619020 1 0 0 -Pea15 PEA-15 Apoptosis; Motility/polarity/chemotaxis Q62048 18611 1 H3|1 79.54 cM mouse S104-p 455750 TKLTRIPsAKKYKDI molecular association, regulation cell cycle regulation ERK1(DISRUPTS); ERK2(DISRUPTS) 15917297 13 27 322 -BTK Btk EC 2.7.10.2; KINASE; Kinase, protein; Protein kinase, TK; Protein kinase, tyrosine (non-receptor) Q06187 695 Xq22.1 human Y551-p 447486 RYVLDDEyTSSVGSK PK_Tyr_Ser-Thr activity, induced; molecular association, regulation; intracellular localization; enzymatic activity, induced signaling pathway regulation Hck(INDUCES); BLNK(INDUCES) 11226282; 11413148; 14597636; 17264076; 21482705; 21659545; 35639855; 37175486; 37197664; 8629002 34 14 136 Induce calcium signaling; regulates B cell receptor (BCR) signaling; Ca mobilization induced -Sqstm1 SQSTM1 Autophagy; Nuclear receptor co-regulator; Ubiquitin conjugating system Q64337 18412 11|11 B1.3 mouse T269-p 457004 GGKRSRLtPTTPESS cell cycle regulation; carcinogenesis, altered; transcription, induced; signaling pathway regulation 20974803; 33395605 9 74 136 Keap1-Nrf2 signaling; in Ras-transformed embryonic fibroblasts -SLC12A3 NCCT Membrane protein, integral; Membrane protein, multi-pass; Transporter; Transporter, SLC family P55017 6559 16q13 human T55-p 469616 SSTFCMRtFGYNTID AA_permease_N activity, induced; molecular association, regulation; protein conformation ADD3(DISRUPTS) 21164023; 36792826 25 3 0 -LDHA LDH-A Amino Acid Metabolism - cysteine and methionine; Apoptosis; Carbohydrate Metabolism - glycolysis and gluconeogenesis; Carbohydrate Metabolism - propanoate; Carbohydrate Metabolism - pyruvate; EC 1.1.1.27; Oxidoreductase P00338 3939 11p15.1 human Y10-p 454712 TLKDQLIyNLLKEEQ molecular association, regulation; protein conformation; enzymatic activity, induced carcinogenesis, induced; cell motility, induced; apoptosis, induced; cell growth, induced; apoptosis, inhibited LDH-A(INDUCES) 21969607; 28122247; 28218905; 33572095; 34452627; 35115484; 35525866; 37507768 8 24 374 -SHOC2 SHOC2 Adaptor/scaffold; Protein phosphatase, regulatory subunit Q9UQ13 8036 10q25.2 human T71-p 34669125 VAFSVDNtIKRPNPA protein degradation; ubiquitination cell growth, inhibited; cell motility, inhibited 29383184 1 2 1 -Caly calcyon Membrane protein, integral P58821 192349 1q41 rat S169-p 25687501 MPAIWGNsYRAGKEE Calcyon molecular association, regulation signaling pathway regulation PSD-95(INDUCES) 22843680 1 0 0 inhibits D1DR signaling and surface levels -ICAM3 ICAM3 Cell adhesion; Immunoglobulin superfamily; Membrane protein, integral P32942 3385 19p13.2 human S518-p 451020 REHQRSGsYHVREES activity, induced; intracellular localization 11784723; 9268366 2 0 5 S518A mutation blocked interleukin-2 secretion, aggregation, and cell spreading -LIX1L LIX1L RNA-binding Q8IVB5 128077 1q21.1 human Y136-p 48963900 VPSNSPPyVCYVTLP LIX1 carcinogenesis, induced; cell growth, induced; apoptosis, inhibited 26310847 1 0 0 -Epha3 EphA3 EC 2.7.10.1; KINASE; Kinase, protein; Membrane protein, integral; Protein kinase, TK; Protein kinase, tyrosine (receptor) P29319 13837 16|16 C1.3 mouse Y779-p 448910 EDDPEAAyTTRGGKI PK_Tyr_Ser-Thr cell cycle regulation; carcinogenesis, altered; cell motility, altered 18515860; 20697431 3 33 700 -CD6 CD6 Cell surface; Membrane protein, integral P30203 923 11q12.2 human S480-p 28095001 PPPEDSDsGSDSDYE phosphorylation signaling pathway regulation 23711376 1 0 0 ERK1/2 phosphorylation, MAPK pathway activation -SLC12A4 KCC1 Membrane protein, integral; Membrane protein, multi-pass; Transporter; Transporter, SLC family Q9UP95 6560 16q22.1 human Y1056-p 3087800 NSEGDENyMEFLEVL SLC12 activity, inhibited 10942735 1 0 0 -Alk ALK EC 2.7.10.1; KINASE; Kinase, protein; Membrane protein, integral; Oncoprotein; Protein kinase, TK; Protein kinase, tyrosine (receptor) P97793 11682 17 E1.3|17 43.77 cM mouse Y1592-p 450381 CGNVNYGyQQQGLPL carcinogenesis, induced; transcription, induced 36602782 3 1 27 -TXK TXK EC 2.7.10.2; KINASE; Kinase, protein; Protein kinase, TK; Protein kinase, tyrosine (non-receptor) P42681 7294 4p12 human Y91-p 2861416 KIQVKALyDFLPREP SH3_1 transcription, altered 12081135 2 2 0 -Hdac6 HDAC6 DEACETYLASE; Deacetylase; EC 3.5.1.98; Nuclear receptor co-regulator; Ubiquitin conjugating system Q9Z2V5 15185 X A1.1|X 3.58 cM mouse S59-p 4759169 KGKMKKLsQPAEEDL protein degradation; ubiquitination cytoskeletal reorganization 37450577 1 6 0 -H2BC3 H2B DNA-binding P33778 3018 6p22.2 human S32-p 447801 DGKKRKRsRKESYSI Histone cell growth, induced; translation, induced 21646345 7 0 0 transformation -PPP1R3B PPP1R3B Protein phosphatase, regulatory subunit Q86XI6 79660 8p23.1 human Y285-p 1065300 YEKLGPYy_______ molecular association, regulation PYGM(INDUCES) 17870073 1 0 0 -TIAM1 TIAM1 GEF; GEF, Rac/Rho; Motility/polarity/chemotaxis; Oncoprotein Q13009 7074 21q22.11 human S334-p 35524908 EGSEFADsGIEGATT protein degradation; molecular association, regulation BTRC(INDUCES) 25124033 1 1 0 -Ulk1 ULK1 Autophagy; EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, Other; Protein kinase, Ser/Thr (non-receptor) O70405 22241 5|5 F mouse T635-gl 231166705 PSFDFPKtPSSQNLL molecular association, regulation AMPKA1(INDUCES) 28903979 1 0 0 -Clip1 Restin Cytoskeletal Q9JK25 65201 12q16 rat S311-p 4769833 ASLKRSPsASSLSSM molecular association, regulation; protein conformation TUBA1C(DISRUPTS) 20519438 4 13 1 -Mtor mTOR Autophagy; EC 2.7.11.1; KINASE; Kinase, protein; Motility/polarity/chemotaxis; Protein kinase, Ser/Thr (non-receptor); Protein kinase, atypical P42346 56718 5q36 rat S2448-p 447578 RSRTRTDsYSAGQSV translation, altered 11884412 218 18 106 -KCNMB4 KCNMB4 Channel, potassium; Membrane protein, integral; Membrane protein, multi-pass Q86W47 27345 12q15 human S17-p 451269 YTEAEDKsIRLGLFL CaKB activity, inhibited 11790768 1 0 0 regulates slowpoke K(+) channel kinetics -MORC3 MORC3 Cell cycle regulation; RNA-binding Q14149 23515 21q22.12 human K651-sm 14988618 VPSLVVKkEETVEDE molecular association, regulation PML(INDUCES) 20501696 1 1 0 -TLE1 TLE1 Nuclear receptor co-regulator; Transcription, coactivator/corepressor Q04724 7088 9q21.32 human S253-p 23940705 DNLVVDVsNEDPSSP apoptosis, inhibited 22354967 1 2 0 -KRT18 K18 Cytoskeletal; Nucleolus P05783 3875 12q13.13 human K207-sm 25027602 ETEIEALkEELLFMK Filament cytoskeletal reorganization 21062750 1 0 0 sumoylation regulate solubility; modified by poly-SUMO-2/3 chains, oxidative stress, apoptosis, and/or phosphatase inhibition increase sumoylation in primary hepatocytes; K to R mutants show filament disorganization -CD300LF IREM-1 Immunoglobulin superfamily; Membrane protein, integral; Receptor, misc. Q8TDQ1 146722 17q25.1 human T221-p 1868016201 GTSPQKAtTKLSSAQ SIT signaling pathway regulation 32152116 1 0 0 -WASF2 WAVE2 Actin-binding; Motility/polarity/chemotaxis Q9Y6W5 10163 1p36.11 human Y150-p 455197 GKEALKFyTDPSYFF molecular association, regulation; intracellular localization cytoskeletal reorganization Abi-1(INDUCES) 15657136 3 0 0 -BRD4 BRD4 KINASE; Kinase, protein; Protein kinase, Ser/Thr (non-receptor); Protein kinase, atypical O60885 23476 19p13.12 human Y97-p 1874101902 VKLNLPDyYKIIKTP Bromodomain protein stabilization; molecular association, regulation; ubiquitination carcinogenesis, induced; chromatin organization, altered; transcription, induced BET1(DISRUPTS); STAT3(INDUCES); UCHL3(INDUCES) DNA(INDUCES) 34290255 1 1 0 inhibits ubiquitination -Irs2 IRS2 Adaptor/scaffold; Motility/polarity/chemotaxis F1MAL5 29376 16q12.5 rat S574-p 483923 GLRKRTYsLTTPARQ molecular association, regulation; phosphorylation 14-3-3 beta(INDUCES) 22912850 2 40 11 negatively regulates IGF-1/insulin signaling -Add2 ADD2 Cytoskeletal; Motility/polarity/chemotaxis Q05764 24171 4q34 rat S692-p 454590 SVTSGPLsPEGSPSK cytoskeletal reorganization 21606488 1 16 0 -G3BP1 G3BP-1 Adaptor/scaffold; EC 3.6.4.12; EC 3.6.4.13; Helicase; RNA-binding Q13283 10146 5q33.1 human K376-ac 466023 LRINSGGkLPNFGFV RRM_1 molecular association, regulation PABP 1(DISRUPTS) RNA(DISRUPTS) 31481451 1 5 6 K376 acetylation led to SG disassembly -Pik3r1 PIK3R1 KINASE; Kinase, lipid; Motility/polarity/chemotaxis P26450 18708 13 D1|13 53.92 cM mouse S690-p 25018700 EPYNLYSsLKELVLH SH2 molecular association, regulation; intracellular localization; phosphorylation signaling pathway regulation GAB1(DISRUPTS); IRS1(DISRUPTS) 22342344 1 1 0 inhibits AKT phosphorylation therefore it regulates PI3K/AKT and mTOR/S6 signaling pathway -Kcnb1 Kv2.1 Channel, cation; Channel, ligand-gated; Channel, potassium; Membrane protein, integral; Membrane protein, multi-pass P15387 25736 3q42 rat S541-p 473556 SKMAKTQsQPILNTK Kv2channel activity, inhibited 16917065 3 7 0 -PRDX2 PRDX2 EC 1.11.1.15; Oxidoreductase P32119 7001 19p13.13 human S76-p 1869663300 GCEVLGVsVDSQFTH AhpC-TSA molecular association, regulation PRDX2(DISRUPTS) 32601209 1 0 0 -ATM ATM DNA repair, damage; EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, Ser/Thr (non-receptor); Protein kinase, atypical; Tumor suppressor Q13315 472 11q22.3 human S1987-p 62382603 GSQSTTIsSLSEKSK enzymatic activity, inhibited; protein conformation cell cycle regulation; apoptosis, inhibited 27939942 2 0 0 -Arhgef7 ARHGEF7 GEF; GEF, Rac/Rho; Motility/polarity/chemotaxis Q9ES28 54126 8|8 A1.1 mouse T683-p 455216 EFAVRKStAALEEDA RhoGEF67_u2 intracellular localization 12226077 7 6 1 -Ahcyl1 AHCYL1 Amino Acid Metabolism - cysteine and methionine; EC 3.3.1.1; Hydrolase; Other Amino Acids Metabolism - selenoamino acid Q80SW1 229709 3 F2.3|3 46.83 cM mouse S66-p 50680601 GRRSLSRsISQSSTD molecular association, regulation PIP5K1A(INDUCES) 26509711 1 0 0 -Sharpin SHARPIN Apoptosis Q91WA6 106025 15 D3|15 35.75 cM mouse K168-ub 54221301 PQSSGNFkKEELATR signaling pathway regulation 26829767 1 1 0 regulation of TCR signaling-maintenance of immuno; ogical signaling K63-linked polyubiquitination -Prkd1 PRKD1 Autophagy; EC 2.7.11.13; KINASE; Kinase, protein; Motility/polarity/chemotaxis; Protein kinase, CAMK; Protein kinase, Ser/Thr (non-receptor) Q9WTQ1 85421 6q22 rat S203-p 449896 GVRRRRLsNVSLTGL intracellular localization 28408623 8 36 86 translocation from the membrane to the interior of the cell -PREX2 PREX2 GEF; GEF, Rac/Rho; Phosphatase, regulatory subunit Q70Z35 80243 8q13.2 human S1107-p 35483225 DTISNRDsYSDCNSN intracellular localization; activity, inhibited 26438819 1 0 0 -SMAD3 SMAD3 DNA-binding; Nuclear receptor co-regulator; Transcription factor P84022 4088 15q22.33 human T8-p 452179 MSSILPFtPPIVKRL cell cycle regulation; transcription, inhibited; transcription, altered 15241418; 20736297 5 13 0 -SRC Src EC 2.7.10.2; KINASE; Kinase, protein; Oncoprotein; Protein kinase, TK; Protein kinase, tyrosine (non-receptor) P12931 6714 20q11.23 human Y419-p 448234 RLIEDNEyTARQGAK PK_Tyr_Ser-Thr activity, induced; molecular association, regulation; intracellular localization; phosphorylation; enzymatic activity, induced cell cycle regulation; carcinogenesis, induced; cell motility, induced; cell adhesion, induced; cell motility, inhibited; cell adhesion, inhibited; signaling pathway regulation; RNA splicing, induced; cell growth, induced; cell motility, altered; cell growth, altered; cell differentiation, inhibited; carcinogenesis, inhibited; carcinogenesis, altered; transcription, induced; transcription, altered; apoptosis, inhibited; cytoskeletal reorganization; cell adhesion, altered ITGB3(INDUCES); Cbl-c(INDUCES); SHPS1(INDUCES); DOR-1(INDUCES); FBXL7(INDUCES) 11600431; 11804588; 12052863; 12473651; 14661060; 14720123; 15899872; 18454177; 19014372; 20129247; 20211239; 20501847; 21442427; 21873224; 21878628; 23471971; 23612968; 23644655; 24632852; 25947380; 26918609; 27101103; 30095367; 30664792; 31619538; 31973024; 32002121; 32539222; 32839549; 33761359; 33903122; 34088769; 34148056; 34226698; 34240802; 34335982; 34375550; 34532864; 34588619; 34642304; 34856074; 35131384; 35257717; 35297710; 35697802; 35713503; 35773413; 35810308; 35830815; 35948987; 35999654; 36268559; 36319849; 36443287; 36862682; 37330581; 37402225; 9271228 447 103 3046 -CAMK2G CAMK2G EC 2.7.11.17; KINASE; Kinase, protein; Protein kinase, CAMK; Protein kinase, Ser/Thr (non-receptor) Q13555 818 10q22.2 human S26-p 455247 ELGKGAFsVVRRCVK Pkinase enzymatic activity, inhibited; phosphorylation 23289753 1 3 0 phosphorylation works as an internal break, switching off the constitutively active oligomeric CaMKII.; decreases T287 autophosphorylation -NF1 NF1 iso2 GAP; GAP, Ras; Motility/polarity/chemotaxis; Nucleolus; Tumor suppressor P21359-2 4763 17q11.2 human T2554-p 456019 KMRRVAEtDYEMETQ molecular association, regulation; activity, inhibited 14-3-3 beta(INDUCES) 14741381 1 1 0 -Prkd1 PRKD1 Autophagy; EC 2.7.11.13; KINASE; Kinase, protein; Motility/polarity/chemotaxis; Protein kinase, CAMK; Protein kinase, Ser/Thr (non-receptor) Q62101 18760 12|12 B3 mouse Y469-p 448648 NDTGSRYyKEIPLSE PH enzymatic activity, induced 15084589 7 0 0 -Sox9 SOX9 DNA-binding; Transcription factor Q04887 20682 11 E2|11 77.27 cM mouse S211-p 450957 FKALQADsPHSSSGM activity, induced transcription, altered 19113914 2 1 0 promotes expression of osteochondrogenic markers -Myocd myocardin Cell development/differentiation; Transcription factor Q8VIM5 214384 11|11 B3 mouse S866-p 10791201 SPMHAQLsPPSVDSS molecular association, regulation transcription, inhibited CBP(DISRUPTS) 19776005 1 0 0 -MDC1 MDC1 Cell cycle regulation Q14676 9656 6p21.33 human K1840-sm 55434044 SQKTVIIkEEEEDTA protein degradation; molecular association, regulation; ubiquitination DNA repair, induced; DNA repair, altered CtIP(INDUCES); RAD51(INDUCES) 22635276; 28275011; 30796017 3 3 0 recruitment of ataxin-3 to DSBs is dependent on SUMOylation; SENP2 regulates MDC1 SUMOylation DSB repair responses -MCM3 MCM3 DNA replication; EC 3.6.4.12 P25205 4172 6p12.2 human K351-ub 21178624 IGDPSVAkSQLLRYV MCM cell cycle regulation 27621311 1 4 0 KEAP1-MCM3 associates with chromatin in a cell cycle-dependent manner -Epha8 EphA8 EC 2.7.10.1; KINASE; Kinase, protein; Membrane protein, integral; Protein kinase, TK; Protein kinase, tyrosine (receptor) O09127 13842 4|4 D3 mouse Y615-p 448558 FSAEPHTyEEPGRAG EphA2_TM molecular association, regulation cell adhesion, altered Fyn(INDUCES) 10498895 1 0 0 -LTB4R LTB4R GPCR, family 1; Membrane protein, integral; Membrane protein, multi-pass; Receptor, GPCR Q15722 1241 14q12 human S310-p 13310168 KLLEGTGsEASSTRR receptor internalization, induced cell motility, induced; signaling pathway regulation 22707565; 30131369 3 2 0 directionality of chemotaxis ; enhanced ligand-induced internalization ; chemotaxis, B-hexisaminidase release, regulates LTB4R function -PIAS1 PIAS1 EC 6.3.2.-; Nuclear receptor co-regulator; SUMO LIGASE; SUMO conjugating system; SUMO ligase; Transcription, coactivator/corepressor O75925 8554 15q23 human K117-sm 580826070 PVSLLGPkHELELPH protein degradation; ubiquitination; intracellular localization MDM2(INDUCES) 31620784; 31752909 2 2 0 sumoylated PIAS1/SUMO3 induced AR cytoplasmic translocation and subsequent ubiquitination-mediated degradation; AR caused by sumoylated PIAS1 to its proteasome-dependent degradation; MDM2 is recruited to induce AR degradation; cytoplasmic localization (K388), AR-PIAS1- or SUMO3-modified PIAS1 interactions, AR and sumoylated PIAS1 complex -PTPN6 SHP-1 EC 3.1.3.48; Motility/polarity/chemotaxis; PHOSPHATASE; Protein phosphatase, tyrosine (non-receptor) P29350 5777 12p13.31 human Y301-p 464270 SNIPGSDyINANYIK Y_phosphatase molecular association, regulation transcription, inhibited; signaling pathway regulation GRB2(INDUCES) 14551136 1 2 69 recruitment of Grb2 targets SOCS-1 to Jak2 -Ulk1 ULK1 Autophagy; EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, Other; Protein kinase, Ser/Thr (non-receptor) O70405 22241 5|5 F mouse T180-p 21041603 QSNMMAAtLCGSPMY Pkinase phosphorylation; enzymatic activity, induced carcinogenesis, induced; autophagy, induced; signaling pathway regulation 21819378; 35246531 2 0 0 -LASP1 Lasp-1 Actin-binding; Motility/polarity/chemotaxis Q14847 3927 17q12 human Y171-p 451675 IPTSAPVyQQPQQQP molecular association, regulation; intracellular localization; protein conformation; phosphorylation carcinogenesis, induced; apoptosis, induced; cell motility, altered CXCR4(DISRUPTS); CRKL(INDUCES); AGO2(INDUCES); Akt1(DISRUPTS) 15138294; 19718473; 24913448; 32075106; 32872485 5 9 426 important for cell spreading; inhibits phosphorylation at S146 -Grin2a NMDAR2A Channel, ligand-gated; Membrane protein, integral; Membrane protein, multi-pass Q00959 24409 10q11 rat S580-p 1871177709 VFVFEYFsPVGYNRN Lig_chan intracellular localization; activity, inhibited cell cycle regulation 33184446 1 0 0 -HMGN1 HMGN1 DNA-binding; Nuclear receptor co-regulator P05114 3150 21q22.2 human K31-ac 458846 LSAKPPAkVEAKPKK HMG14_17 molecular association, regulation DNA(DISRUPTS) 10753971 1 0 2 -GPRC5A RAIG1 GPCR, family 3; Membrane protein, integral; Membrane protein, multi-pass; Receptor, GPCR Q8NFJ5 9052 12p13.1 human Y347-p 450338 AHAWPSPyKDYEVKK cell growth, induced 25311788 1 24 826 Tyrosine phosphorylation inhibits the suppressive effect of RAIG1 on cell invasion and anchorage-independent growth. -CSNK1E CK1E EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, CK1; Protein kinase, Ser/Thr (non-receptor) P49674 1454 22q13.1 human T334-p 453418 ALPPGPPtGATANRL enzymatic activity, inhibited 10542239; 12223474 2 0 0 some subset of these 8 sites -Itgb3 ITGB3 Cell adhesion; Membrane protein, integral; Motility/polarity/chemotaxis O54890 16416 11 E1|11 67.84 cM mouse Y772-p 448012 DTANNPLyKEATSTF Integrin_b_cyt molecular association, regulation; protein processing; activity, inhibited SHC1(INDUCES); DOK1(INDUCES) 10964917; 16935858; 23983218 22 10 95 inhibits m-calpain cleavage; inhibits beta 3 integrin signaling -MYL12A MRLC3 Contractile P19105 10627 18p11.31 human Y155-p 7382105 DKKGNFNyIEFTRIL EF-hand_11 molecular association, regulation; intracellular localization; protein conformation; phosphorylation cytoskeletal reorganization; cell motility, inhibited; cell adhesion, inhibited MYH2(DISRUPTS) 32502416 1 4 48 induces phosphorylation at the other sites -CYBA CYBA EC 1.-.-.-; Membrane protein, integral; Oxidoreductase P13498 1535 16q24.2 human T147-p 7103047 ERPQIGGtIKQPPSN Cytochrom_B558a molecular association, regulation; enzymatic activity, induced p47phox(INDUCES) 19948736 3 13 5 -Rac2 RAC2 G protein; G protein, monomeric; G protein, monomeric, Rho; Motility/polarity/chemotaxis Q05144 19354 15|15 E1 mouse K123-ub 12402500 KLDLRDDkDTIEKLK Ras protein degradation; molecular association, regulation; ubiquitination ALDH2(INDUCES) 35354308 1 7 2 rs671 mutation had significantly lower efferocytotic ability compared with wild-type, ALDH2 WT interacted with RAC2 and stabilized it by inhibited K48-linked polyubiquitination at K123. -INSR INSR EC 2.7.10.1; KINASE; Kinase, protein; Membrane protein, integral; Protein kinase, TK; Protein kinase, tyrosine (receptor) P06213 3643 19p13.2 human Y1185-p 447680 FGMTRDIyETDYYRK PK_Tyr_Ser-Thr molecular association, regulation; receptor internalization, altered; enzymatic activity, induced signaling pathway regulation IRS2(INDUCES); APS(INDUCES); PTP1B(INDUCES) 10852715; 12917346; 14690593; 1658004; 22081023; 8024702; 8999839; 9195949 38 31 455 morphine-inhibited insulin receptor signaling -Add3 ADD3 Cytoskeletal; Motility/polarity/chemotaxis Q62847 25230 1q55 rat S692-p 452158 KKKFRTPsFLKKNKK intracellular localization 9607561 2 56 164 -EFNB1 EFNB1 Ligand, receptor tyrosine kinase; Membrane protein, integral P98172 1947 Xq13.1 human Y317-p 448341 ENNYCPHyEKVSGDY cell adhesion, induced; signaling pathway regulation 16211011 2 17 189 -Nfatc4 NFAT3 DNA-binding; Transcription factor Q8K120 73181 14|14 C3 mouse S168-p 448859 QGGGAFFsPSPGSSS intracellular localization; activity, inhibited transcription, altered 18347059; 18691762; 27307045 7 0 1 -HSP90AA1 HSP90A Chaperone; Heat shock protein P07900 3320 14q32.31 human Y309-p 3798180 DDITNEEyGEFYKSL HSP90 protein conformation 23867252 1 1 3 phosphorylation induces altered conformation and governs drug specificity. -MICAL1 MICAL1 Adaptor/scaffold; EC 1.14.13.-; Motility/polarity/chemotaxis Q8TDZ2 64780 6q21 human S960-p 6226101 ELALRRQsSSPEQQK bMERB_dom molecular association, regulation cytoskeletal reorganization 14-3-3 epsilon(INDUCES); Rab7(INDUCES); RAB10(INDUCES) 36198272 1 2 7 -Nfatc2 NFAT1 DNA-binding; Transcription factor Q60591 18019 2 H3|2 88.91 cM mouse S219-p 447846 AHYSPRTsPIMSPRT protein stabilization; ubiquitination carcinogenesis, induced; cell growth, induced; transcription, induced; transcription, inhibited 11030334; 21628454 2 12 3 inhibits ubiquitination of NFAT1 residues K684 and K897 -BHLHE40 BHLHB2 Nucleolus; Transcription regulation O14503 8553 3p26.1 human S243-p 36324900 GSDTDTDsGYGGESE protein degradation cell cycle regulation 25202122 1 0 0 -WWC1 KIBRA Adaptor/scaffold Q8IX03 23286 5q34 human S931-p 3205620 IIRSKTFsPGPQSQY cell cycle regulation 22784093 1 5 1 -CENPA CENPA DNA-binding P49450 1058 2p23.3 human S7-p 448601 _MGPRRRsRKPEAPR Histone molecular association, regulation; intracellular localization cell cycle regulation; chromatin organization, altered AurA(INDUCES) 11756469; 14667408 18 0 0 Aurora B, INCEP and PP1gamma are mislocalized during anaphase in mitosis in mutants. ; S7A mutation causes defective kinetochore function and mislocalization of Aurora B. -TGM2 TGM2 EC 2.3.2.13; KINASE; Transferase P21980 7052 20q11.23 human S216-p 467223 RDCSRRSsPVYVGRV molecular association, regulation signaling pathway regulation 14-3-3 epsilon(INDUCES) 16870138; 22142843 3 4 2 activation of Akt-signaling pathway, downregulation of EGFR -Ncam1 NCAM1 Cell adhesion; Membrane protein, GPI anchor; Membrane protein, integral; Motility/polarity/chemotaxis P13596 24586 8q23 rat Y744-p 454070 VVMDITCyFLNKCGL cell growth, altered 20605779 2 0 0 -TSC2 TSC2 Cell cycle regulation; GAP; GAP, misc.; Nuclear receptor co-regulator; Tumor suppressor P49815 7249 16p13.3 human S1217-p 1868502602 MSLENPLsPFSSDIN activity, inhibited; phosphorylation cell cycle regulation; cell growth, induced; translation, induced 32294430 1 0 0 induces S6K phosphorylation -Cnr1 CNR1 GPCR, family 1; Membrane protein, integral; Membrane protein, multi-pass; Receptor, GPCR P47746 12801 4 A5|4 16.28 cM mouse S463-p 22342305 KIAKVTMsVSTDTSA receptor desensitization, induced 22014214 1 0 0 -NEK6 NEK6 EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, Other; Protein kinase, Ser/Thr (non-receptor) Q9HC98 10783 9q33.3 human Y108-p 12475501 NHPNIIKyLDSFIED Pkinase enzymatic activity, inhibited 19941817 1 0 0 -RPS6KB2 P70S6KB EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, AGC; Protein kinase, Ser/Thr (non-receptor); Translation Q9UBS0 6199 11q13.2 human S417-p 455990 SPRRLNSsPRAPVSP enzymatic activity, induced 11108720 2 10 11 -OSBP OSBP Lipid-binding P22059 5007 11q12.1 human S240-p 484804 TALQRSLsELESLKL activity, inhibited 21285358 2 45 16 -Gja1 GJA1 Channel, misc.; Membrane protein, integral; Membrane protein, multi-pass; Motility/polarity/chemotaxis P08050 24392 20q11 rat Y247-p 447814 VKGRSDPyHATTGPL activity, induced; molecular association, regulation; intracellular localization; activity, inhibited carcinogenesis, altered; cytoskeletal reorganization; cell growth, altered TUBB(DISRUPTS); PTPN2(INDUCES) 14681032; 16916748; 20676131; 24849651; 27235399; 27391443; 32956670 14 9 248 allows anchorage-independent growth; inhibits Src activity; disrupts gap junction communication; regulation of gap junction intercellular communication -KCNQ2 Kv7.2 Channel, potassium; Membrane protein, integral; Membrane protein, multi-pass O43526 3785 20q13.33 human S414-p 58948900 KDPPPEPsPSKGSPC activity, inhibited neural plasticity 36070693 1 2 0 -CFTR CFTR Channel, chloride; EC 3.6.3.49; Hydrolase; Membrane protein, integral; Membrane protein, multi-pass; Transporter; Transporter, ABC family P13569 1080 7q31.2 human S422-p 3333404 NNNNRKTsNGDDSLF activity, induced 21930781 4 3 0 -Mafb MAFB DNA-binding; Oncoprotein; Transcription factor; Tumor suppressor P54841 16658 2 H2|2 80.92 cM mouse K297-sm 12004403 ERDAYKVkCEKLANS bZIP_Maf cell differentiation, inhibited; cell cycle regulation; cell growth, induced; transcription, inhibited 17548468 1 0 0 -EP300 p300 ACETYLTRANSFERASE; Acetyltransferase; EC 2.3.1.48; Motility/polarity/chemotaxis; Nuclear receptor co-regulator; Transcription, coactivator/corepressor Q09472 2033 22q13.2 human S2039-p 31828207 GLGQVGIsPLKPGTV Creb_binding protein degradation; acetylation cell cycle regulation; carcinogenesis, induced; chromatin organization, altered; cell motility, induced; cell growth, induced; transcription, inhibited 24530506 1 0 0 Decrease histone H3-acetylation -MEF2C MEF2C DNA-binding; Transcription factor Q06413 4208 5q14.3 human K264-ac 12674409 VLIPPGSkNTMPSVS molecular association, regulation cell differentiation, induced; transcription, induced MRF(INDUCES) DNA(INDUCES) 15831463 1 0 0 -Syk Syk EC 2.7.10.2; KINASE; Kinase, protein; Protein kinase, TK; Protein kinase, tyrosine (non-receptor) P48025 20963 13 A5|13 27.41 cM mouse Y346-p 447660 TEVYESPyADPEEIR molecular association, regulation; enzymatic activity, inhibited; phosphorylation; enzymatic activity, induced endocytosis, altered; cell motility, altered; cell adhesion, altered; signaling pathway regulation FGR(INDUCES) 11672534; 12077122; 15536084; 15576379; 27609517; 37268160 38 22 248 Mutant Y342F/346F Syc showed less efficient FcERI-induced degranulation, and delayed calcium influx. ; inhibits phosphorylation of itself at Y342 and of LAT and PLCG2, thus inhibiting GPVI-mediated signaling; AKT phosphorylation -Aqp2 AQP2 Channel, misc.; Membrane protein, integral; Membrane protein, multi-pass; Transporter; Transporter, aquaporin family P34080 25386 7q36 rat S256-p 449854 REVRRRQsVELHSPQ activity, induced; molecular association, regulation; intracellular localization endocytosis, inhibited GDI2(DISRUPTS); HSP70(DISRUPTS); RAN(DISRUPTS); ANXA2(DISRUPTS); HSC70(DISRUPTS); GRP78(INDUCES); PPP1CA(DISRUPTS) 10653816; 10710543; 12897058; 15010357; 18434387; 19209902; 21148409; 22403603; 23559583; 24700872; 32113684; 32295252 78 9 0 -PDPK1 PDK1 EC 2.7.11.1; KINASE; Kinase, protein; Nuclear receptor co-regulator; Protein kinase, AGC; Protein kinase, Ser/Thr (non-receptor) O15530 5170 16p13.3 human S394-p 12729600 QVSSSSSsHSLSASD apoptosis, altered; cell growth, altered 19920149 2 0 0 -XPC XPC DNA repair, damage Q01831 7508 3p25.1 human S892-p 481830 DEEEGTSsQAEAARI DNA repair, inhibited 29660033 1 3 3 -TOP2A TOP2A EC 5.99.1.3; Isomerase P11388 7153 17q21.2 human S1365-p 18016961 TKTSPKLsNKELKPQ protein degradation; molecular association, regulation; ubiquitination; phosphorylation FBXW7(INDUCES) 21254166 1 3 0 -Slc1a2 GLT1 Membrane protein, integral; Membrane protein, multi-pass; Transporter; Transporter, SLC family P43006 20511 2 E2|2 54.13 cM mouse K549-ub 4667700 SVVIDECkVTLAANG molecular association, regulation GLT1(INDUCES) 35938532 2 0 0 formation of oligomers, epileptic seizures inhibited by APAP treatment -Numbl NUMBL Cell development/differentiation A1L1I3 292732 1q21 rat S305-p 456489 EQLVRQGsFRGFPAL NumbF molecular association, regulation 14-3-3 eta(INDUCES) 16105844 1 16 7 -OPTN optineurin Inhibitor Q96CV9 10133 10p13 human K501-ub 12313403 LQLAVLLkENDAFED CC2-LZ protein degradation autophagy, induced 32014991 1 1 42 required for proper proteostasis of DBR exposed SOD1 -E2F1 E2F1 DNA-binding; Transcription factor Q01094 1869 20q11.22 human K117-ac 459017 GRGRHPGkGVKSPGE protein stabilization; molecular association, regulation apoptosis, induced; transcription, induced DNA(INDUCES) 10675335; 10753885; 22184068 3 0 0 etoposide-induced DNA damage, pRB-free form of E2F1, does not bind to pRB; both complexes act in parallel to induce transcription of proapoptotic genes -MCM7 MCM7 DNA replication; EC 3.6.4.12; Motility/polarity/chemotaxis P33993 4176 7q22.1 human Y600-p 463418 WASKDATyTSARTLL MCM_lid molecular association, regulation cell cycle regulation; carcinogenesis, induced; cell growth, induced MCM2(INDUCES); MCM5(INDUCES); MCM3(INDUCES) DNA(INDUCES) 23764002 1 3 39 enhances binding at DNA replication origins -KAT5 Tip60 ACETYLTRANSFERASE; Acetyltransferase; EC 2.3.1.48; Nuclear receptor co-regulator; Nucleolus Q92993 10524 11q13.1 human Y44-p 28132103 ISGRKLFyVHYIDFN Tudor-knot molecular association, regulation; phosphorylation; enzymatic activity, induced cell cycle regulation; DNA repair, induced H3(INDUCES); AGO2(INDUCES) DNA(INDUCES) 23708966; 26822153 2 0 0 ATM autophosphorylation -DEPTOR DEPTOR Apoptosis Q8TB45 64798 8q24.12 human S258-p 8089037 QSHDNRKsTSFMSVS protein degradation; molecular association, regulation carcinogenesis, induced; apoptosis, inhibited; signaling pathway regulation mTOR(DISRUPTS) 19446321 1 2 1 PI3K-Akt signaling -MRE11 MRE11A Cell cycle regulation; DNA repair, damage; DNA-binding; Deoxyribonuclease P49959 4361 11q21 human T329-p 11506402 NPDNPKVtQAIQSFC Mre11_DNA_bind molecular association, regulation DNA(DISRUPTS) 19709933 1 0 0 -SMAD4 SMAD4 DNA-binding; Nuclear receptor co-regulator; Transcription, coactivator/corepressor Q13485 4089 18q21.2 human T197-p 1876808208 ASTETYStPALLAPS protein degradation; ubiquitination carcinogenesis, induced; cell motility, induced; cell growth, induced; transcription, induced 35437307 1 0 0 -F2R PAR1 Cell development/differentiation; GPCR, family 1; Membrane protein, integral; Membrane protein, multi-pass; Receptor, GPCR P25116 2149 5q13.3 human S399-p 3627502 SDPSSYNsSGQLMAS receptor desensitization, altered 10413505 1 1 1 receptor shutoff (not internalization) -Ncoa3 SRC-3 ACETYLTRANSFERASE; Acetyltransferase; EC 2.3.1.48; Motility/polarity/chemotaxis; Nuclear receptor co-regulator; Transcription, coactivator/corepressor O09000 17979 2|2 H3 mouse R1178-m2 2363405 TNTPKQLrMQLQQRL protein degradation transcription, inhibited CBP(INDUCES) 17043108 1 1 22 -Wasf2 WAVE2 Actin-binding; Motility/polarity/chemotaxis Q8BH43 242687 4 D2.3|4 66.22 cM mouse Y150-p 455197 GKEALKFyTNPSYFF cell motility, induced; cytoskeletal reorganization 16899465; 22617848 3 0 0 regulate multipolar-bipolar neuron transition and growth cone activities -AKT1 Akt1 EC 2.7.11.1; KINASE; Kinase, protein; Oncoprotein; Protein kinase, AGC; Protein kinase, Ser/Thr (non-receptor) P31749 207 14q32.33 human T312-p 5862771 TMKTFCGtPEYLAPE Pkinase enzymatic activity, inhibited signaling pathway regulation 23142783 1 2 5 AKT-mTOR pathway -PLD2 PLD2 EC 3.1.4.4; Lipid Metabolism - ether lipid; Lipid Metabolism - glycerophospholipid; Motility/polarity/chemotaxis; Phospholipase O14939 5338 17p13.2 human Y179-p 458807 RLLTMSFyRNYHAMT PX molecular association, regulation; enzymatic activity, induced; phosphorylation cell cycle regulation; cell motility, altered; cell growth, altered GRB2(INDUCES); CD45(DISRUPTS) 16407827; 18006275; 19715678; 20647543 4 0 0 -Htr2c 5-HT(2C) GPCR, family 1; Membrane protein, integral; Membrane protein, multi-pass; Receptor, GPCR P08909 25187 Xq34 rat S459-p 449971 VVSERISsV______ receptor desensitization, altered 10816555 2 0 0 -BCL6 Bcl-6 C2H2-type zinc finger protein; Oncoprotein; Transcription factor P41182 604 3q27.3 human S343-p 471422 KSDCQPNsPTESCSS protein degradation 9649500 2 6 19 -Gli2 GLI2 C2H2-type zinc finger protein; Oncoprotein; Transcription factor Q0VGT2 14633 1 E2.3|1 52.17 cM mouse S923-p 15410484 PLGPRRGsDGPTYSH sumoylation 22549777 2 1 3 -PML PML Nucleolus; Oncoprotein; SUMO LIGASE; SUMO conjugating system; SUMO ligase; Transcription factor; Tumor suppressor; Ubiquitin conjugating system P29590 5371 15q24.1 human K490-sm 2793913 QCPRKVIkMESEEGK DUF3583 protein degradation; molecular association, regulation; ubiquitination; intracellular localization cell differentiation, induced; transcription, induced PIAS1(INDUCES); SUMO1(INDUCES) 10779416; 17989716; 18408733; 19106612; 19380586; 20205709; 23542129; 27099310; 9756909; 9885291 15 6 0 -Frs2 FRS2 Adaptor/scaffold Q8C180 327826 10|10 D2 mouse Y306-p 449783 PPVNKLVyENINGLS molecular association, regulation GRB2(INDUCES) 9182757 3 14 216 -TRIM25 TRIM25 EC 6.3.2.19; EC 6.3.2.n3; Ligase; Nuclear receptor co-regulator; Transcription factor; UBIQUITIN LIGASE; Ubiquitin conjugating system; Ubiquitin ligase Q14258 7706 17q22 human S12-p 1868624700 CPLAEELsCSICLEP protein stabilization; molecular association, regulation; activity, inhibited carcinogenesis, induced; cell growth, induced; signaling pathway regulation TRIM25(DISRUPTS) 31186535 2 0 0 dimerization decreased in S12D mutant -ROCK2 ROCK2 EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, AGC; Protein kinase, Ser/Thr (non-receptor) Q28021 282041 cow S1374-p 468651 MKIQQNQsIRRPSRQ enzymatic activity, induced cell cycle regulation 17446864 2 21 1 alanine mutation of all 4 sites -Ikzf1 Ikaros C2H2-type zinc finger protein; DNA-binding; Transcription factor Q03267 22778 11 A1|11 7.02 cM mouse S13-p 4828300 GQDMSQVsGKESPPV molecular association, regulation; intracellular localization DNA(DISRUPTS) 18223295 1 0 0 -Ulk1 ULK1 Autophagy; EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, Other; Protein kinase, Ser/Thr (non-receptor) O70405 22241 5|5 F mouse S983-p 1869357209 TAERLILsHAVQMVQ DUF3543 cell cycle regulation; autophagy, induced; cell growth, induced 32516310 1 0 0 -Rb1 Rb Nuclear receptor co-regulator; Oncoprotein; Transcription, coactivator/corepressor; Tumor suppressor P13405 19645 14 38.73 cM|14 D3 mouse T246-p 449821 PINGSPRtPRRGQNR molecular association, regulation cell cycle regulation; cell growth, induced; transcription, inhibited E2F1(DISRUPTS) 10207050; 35023164; 9671466 21 23 68 transcriptional downregulation of the E2F-1, E2F-2, dihydrofolate reductase, thymidine kinase, c-myc, proliferating-cell nuclear antigen, p107, and p21/Cip1 genes -NEDD4L NEDD4L EC 6.3.2.-; EC 6.3.2.19; Ligase; UBIQUITIN LIGASE; Ubiquitin conjugating system; Ubiquitin ligase Q96PU5 23327 18q21.31 human S795-p 18963100 VDLKPNGsEIMVTNE HECT enzymatic activity, induced 21501591 1 0 0 regulates Kir2.1 expression at cell membrane -MAVS MAVS Adaptor/scaffold; Membrane protein, integral Q7Z434 57506 20p13 human Y9-p 25687502 PFAEDKTyKYICRNF CARD_2 protein degradation; molecular association, regulation autophagy, induced; transcription, induced; signaling pathway regulation TRAF3(INDUCES); LC3A(INDUCES); TRAF6(INDUCES) 22844514; 28141795 2 0 0 NF-kB-dependent transcription ; RIG-I-mediated IFN-beta signaling; phosphorylation of MAVS at Y9 enhances phosphorylation of IRF3; IFN-B promoter activation, MPTP induced microglial activation and neurotoxicity -MPL MPL Membrane protein, integral; Receptor, cytokine P40238 4352 1p34.2 human Y626-p 450267 THIANHSyLPLSYWQ carcinogenesis, induced; cell differentiation, induced; cell growth, induced; signaling pathway regulation 27222706; 33384332; 36229456 11 1 1 regulates TPO mediated signaling; regulates TPO-R signaling; increase colony-forming unit megakaryocytes -PTEN PTEN Carbohydrate Metabolism - inositol phosphate; EC 3.1.3.16; EC 3.1.3.48; EC 3.1.3.67; Motility/polarity/chemotaxis; Nuclear receptor co-regulator; PHOSPHATASE; Phosphatase, lipid; Tumor suppressor P60484 5728 10q23.31 human T232-p 456214 YSSNSGPtRREDKFM PTEN_C2 cell motility, altered 15793569 1 1 1 -CHEK1 Chk1 EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, CAMK; Protein kinase, Ser/Thr (non-receptor); Tumor suppressor O14757 1111 11q24.2 human K436-ub 6797153 NLLEMDDkILVDFRL protein degradation cell cycle regulation; carcinogenesis, inhibited; apoptosis, induced 19716789 2 1 0 -IRF3 IRF3 DNA-binding; Transcription factor Q14653 3661 19q13.33 human T253-p 55458200 PDPGMSLtDRGVMSY IRF-3 molecular association, regulation; protein conformation transcription, inhibited DNA(DISRUPTS) 27125670 1 0 0 -RPS6KA3 RSK2 EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, AGC; Protein kinase, Ser/Thr (non-receptor) P51812 6197 Xp22.12 human S19-p 7445513 KMAVESPsDSAENGQ molecular association, regulation; enzymatic activity, inhibited carcinogenesis, induced; cell motility, induced; cell growth, induced; transcription, inhibited H2AX(DISRUPTS) 33574926 1 2 0 -HOXB13 HOXB13 DNA-binding; Transcription factor Q92826 10481 17q21.32 human T8-p 34606107 MEPGNYAtLDGAKDI protein degradation; molecular association, regulation; ubiquitination; intracellular localization carcinogenesis, induced; cell growth, induced; transcription, altered SKP2(INDUCES) 37409967 1 0 1 induces nuclear translocation of NFKB -USP13 USP13 DEUBIQUITINASE; EC 3.4.19.12; Protease; Ubiquitin conjugating system; Ubiquitin-specific protease Q92995 8975 3q26.33 human S114-p 3849419 ALPKRRNsKIFLDLD protein stabilization 32772043 1 3 11 induces AurB stabilization -Ctla4 CTLA-4 Immunoglobulin superfamily; Membrane protein, integral P09793 12477 1 C2|1 30.58 cM mouse Y218-p 450898 CEKQFQPyFIPIN__ molecular association, regulation SHP-2(INDUCES) 9973379 3 0 0 -KDM4A JMJD2A DEMETHYLASE; Demethylase; EC 1.14.11.-; Oxidoreductase; Transcription, coactivator/corepressor O75164 9682 1p34.2-p34.1 human K471-sm 63115305 FEELKNVkLEEEDEE sumoylation; molecular association, regulation; methylation apoptosis, altered; chromatin organization, altered; cell growth, induced; cell motility, altered; transcription, induced; transcription, altered DNA(INDUCES) 28212444; 35914074 2 0 0 IL-10 downstream target promoting angiogenesis; SUMOylation is required for PEL cell survival, cell movement and angiogenesis; induces histone demethylation -Stk4 MST1 Autophagy; EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, STE; Protein kinase, Ser/Thr (non-receptor) Q9JI11 58231 2|2 H3 mouse T183-p 447925 DTMAKRNtVIGTPFW Pkinase enzymatic activity, induced cell adhesion, altered 12223493 25 2 5 -ADARB1 RED1 EC 3.5.4.37; Hydrolase; Nucleolus; RNA-binding P78563 104 21q22.3 human S216-p 1040254700 SASPVPAsLAQPPLP enzymatic activity, induced 29694894 1 1 0 regulation of the steady-state levels of miR-200s; metastasis suppressor activity -CERS5 LASS5 DNA-binding; EC 2.3.1.24; Membrane protein, integral; Membrane protein, multi-pass; Transferase Q8N5B7 91012 12q13.12 human S354-p 18260882 DDRSDVEsSSEEEDV enzymatic activity, induced 26887952 1 6 0 -HDAC5 HDAC5 DEACETYLASE; Deacetylase; EC 3.5.1.98; Hydrolase Q9UQL6 10014 17q21.31 human S278-p 4788482 QKVAERRsSPLLRRK molecular association, regulation; enzymatic activity, induced GPS2(INDUCES); N-CoR1(DISRUPTS); SMRT(INDUCES); HDAC3(INDUCES); TBL1X(INDUCES); TBL1XR1(INDUCES); 14-3-3 epsilon(DISRUPTS) 21081666; 22865920 2 14 0 S278/279A mutant shows a slight decrease in the deacetylation activity; reduced NCoR complex ( NCOR1, TBL1X, TBL1XR1) binding in mitotic cells allows for increased phosphorylation of this site by AurB -Slc12a5 KCC2 iso2 Membrane protein, integral; Membrane protein, multi-pass; Transporter; Transporter, SLC family Q63633-2 171373 3q42 rat T906-p 10045603 SAYTYEKtLVMEQRS SLC12 activity, inhibited 24849604; 26126716 7 4 0 -IKBKE IKKE EC 2.7.11.10; Inhibitor; KINASE; Kinase, protein; Protein kinase, Other; Protein kinase, Ser/Thr (non-receptor) Q14164 9641 1q32.1 human Y153-p 56589701 GEEGQSIyKLTDFGA Pkinase enzymatic activity, induced cell motility, induced 27287717 1 1 0 -Fech FECH Cofactor and Vitamin Metabolism - porphyrin and chlorophyll; EC 4.99.1.1; Lyase; Mitochondrial P22315 14151 18 E1|18 37.43 cM mouse S129-p 2048057 YRRIGGGsPIKMWTS Ferrochelatase enzymatic activity, induced 19691493 1 2 0 -Ep300 p300 ACETYLTRANSFERASE; Acetyltransferase; EC 2.3.1.48; Motility/polarity/chemotaxis; Nuclear receptor co-regulator; Transcription, coactivator/corepressor B2RWS6 328572 15|15 E1 mouse S2364-p 486264 MEQGHFAsPDQNSML phosphorylation transcription, induced 21498542 2 0 0 induces NFAT phosphorylation -Rxra RXRA DNA-binding; Motility/polarity/chemotaxis; Nuclear receptor P28700 20181 2 A3|2 19.38 cM mouse T167-p 1868546605 CKGFFKRtVRKDLTY zf-C4 transcription, altered 31152145 1 0 0 regulation of energy (fatty acid) metabolism, glucose homeostasis -PGR PR DNA-binding; Nuclear receptor; Transcription factor P06401 5241 11q22.1 human K388-ub 486290 QPPALKIkEEEEGAE Prog_receptor protein degradation transcription, inhibited 17347654 1 0 0 -HBP1 HBP1 DNA-binding; Transcription factor O60381 26959 7q22.3 human R378-me 1883504200 SSMARQRrASLSCGG protein degradation; ubiquitination cell growth, induced; cytoskeletal reorganization; transcription, inhibited 35941115 1 1 0 methylation alleviates HBP1-mediated suppression of metastasis and growth of tumor cells -MEF2A MEF2A DNA-binding; Motility/polarity/chemotaxis; Transcription factor Q02078 4205 15q26.3 human S255-p 456757 GKVMPTKsPPPPGGG protein degradation 12586839 1 26 0 -TRIM72 TRIM72 UBIQUITIN LIGASE; Ubiquitin conjugating system; Ubiquitin ligase Q6ZMU5 493829 16p11.2 human S255-p 27461213 LQKILAEsPPPARLD molecular association, regulation; enzymatic activity, induced signaling pathway regulation IRS1(INDUCES) 36337049 1 4 0 induces IR degradation, regulates insulin signaling -APOBEC3F APOBEC3F EC 3.5.4.-; Hydrolase; RNA processing Q8IUX4 200316 22q13.1 human S216-p 183815301 KAYGRNEsWLCFTME NAD2 enzymatic activity, inhibited DNA(DISRUPTS) 28825755 1 0 0 -CTDP1 CTDP1 EC 3.1.3.16; Motility/polarity/chemotaxis; PHOSPHATASE; Protein phosphatase, Ser/Thr (non-receptor); Transcription initiation complex Q9Y5B0 9150 18q23 human S740-p 453872 TKAQRENsPAAFPDR FCP1_C molecular association, regulation; enzymatic activity, induced transcription, induced GTF2F2(INDUCES) 12591939 1 36 0 -Elk3 ELK3 DNA-binding; Transcription factor P41971 13713 10 C2|10 48.04 cM mouse S365-p 450032 LSPVAPLsPARLQGP activity, induced; intracellular localization transcription, altered; cell growth, altered 11042694; 18356083 2 0 0 pro-B cell expansion -PARP1 PARP1 DNA repair, damage; EC 2.4.2.30; Nuclear envelope; Nuclear receptor co-regulator; Nucleolus; Transferase P09874 142 1q42.12 human K505-ac 459003 KSGAALSkKSKGQVK molecular association, regulation transcription, induced NFkB-p105(INDUCES) 16204234 1 1 0 -Slamf1 SLAM Membrane protein, integral; Receptor, misc. Q9QUM4 27218 1 H3|1 79.54 cM mouse Y335-p 447634 EPNPTTVyASVTLPE molecular association, regulation Fyn(INDUCES) 11477403 3 0 0 -Tbc1d4 AS160 GAP; GAP, Rab Q8BYJ6 210789 14|14 E2.3 mouse S577-p 455923 AKRSLTSsLENIFSR phosphorylation 33872597 5 48 81 affects phosphorylation of other sites by AKT -PPIF PPIF Cyclophilin; EC 5.2.1.8; Isomerase; Mitochondrial P30405 10105 10q22.3 human S191-p 27460203 IESFGSKsGRTSKKI Pro_isomerase molecular association, regulation apoptosis, induced OSCP1(INDUCES) 32814770 1 2 0 Regulates mitochondrial function; regulates mPTP opening and subsequent cell death -CENPT CENPT DNA replication Q96BT3 80152 16q22.1 human T85-p 3903606 SGHLEEQtPRTLLKN CENP-T_N molecular association, regulation 25660545 3 5 9 KMN network recruitment -Ppara PPAR-alpha DNA-binding; Nuclear receptor; UBIQUITIN LIGASE P37230 25747 7q34 rat S179-p 457549 RFGRMPRsEKAKLKA activity, induced; molecular association, regulation transcription, altered RXRA(INDUCES) 16042408 2 0 0 -Acly ACLY Carbohydrate Metabolism - citrate (TCA) cycle; EC 2.3.3.8; Lyase; Transferase Q91V92 104112 11|11 D mouse H750-p 9643000 SSEVQFGhAGACANQ Ligase_CoA enzymatic activity, induced 18656514 3 0 0 important for cell viability -HCRTR1 HCRTR1 GPCR, family 1; Membrane protein, integral; Membrane protein, multi-pass; Receptor, GPCR O43613 3061 1p35.2 human Y83-p 10206803 HMRTVTNyFIVNLSL 7tm_1; TM molecular association, regulation apoptosis, altered SHP-2(INDUCES) 19661287 1 0 0 -H3C1 H3 DNA-binding P68431 8350 6p22.2 human K9-ac 463820 RTKQTARkSTGGKAP Histone protein degradation; acetylation; molecular association, regulation; intracellular localization; methylation; enzymatic activity, induced cell cycle regulation; carcinogenesis, induced; carcinogenesis, inhibited; apoptosis, induced; cell growth, inhibited; transcription, induced; transcription, altered; neural plasticity; DNA repair, induced; cell growth, induced; chromatin organization, altered; cell differentiation, induced; transcription, inhibited 14-3-3 zeta(INDUCES); RARB(INDUCES); BRD7(INDUCES); WSTF(INDUCES); MLL(INDUCES); CRH(INDUCES); CHD-4(INDUCES); TIF1B(INDUCES); RARA(INDUCES); PCAF(INDUCES); CHD-1(INDUCES); TIF1G(INDUCES) DNA(INDUCES); DNA(DISRUPTS) 12482974; 15471871; 16223729; 17305432; 17498659; 17560255; 17567990; 17938209; 17968314; 17980151; 18179771; 18234970; 18418070; 18985155; 19022177; 19187761; 19196836; 19229332; 19248079; 19337993; 19407812; 19477956; 19523850; 19624289; 19787243; 19883641; 19889207; 19935671; 20043883; 20068219; 20080105; 20093418; 20094059; 20159609; 20180972; 20484083; 20720004; 20829218; 20972224; 21059703; 21196933; 21726812; 22144178; 22408259; 23287868; 23423566; 23518351; 26307012; 26310895; 27508876; 28167529; 28672915; 30867409; 31071955; 32528962; 32733069; 33087562; 34944721; 36060800; 36165173; 36413416 230 26 341 inhibits H3K9 acetylation -RAD52 RAD52 DNA repair, damage P43351 5893 12p13.33 human K323-ac 971232908 GVTQELIkTLEDNSE molecular association, regulation; intracellular localization DNA repair, induced RFA2(INDUCES); RPA3(INDUCES); RAD51(INDUCES); RPA1(INDUCES) 29590107 1 1 0 accumulation of RAD52 at DSB sites -CEACAM1 CEACAM1 Cell adhesion; Immunoglobulin superfamily; Membrane protein, integral; Motility/polarity/chemotaxis P13688 634 19q13.2 human S512-p 29576348 QPTSASPsLTATEII molecular association, regulation; methylation; phosphorylation CTNNB1(INDUCES) 34656562 1 3 0 primes phosphorylation at S508 -SPAST spastin Cytoskeletal; EC 3.6.4.3; Membrane protein, integral Q9UBP0 6683 2p22.3 human S268-p 1211782 SGHHRAPsYSGLSMV protein stabilization; molecular association, regulation; ubiquitination; intracellular localization cell cycle regulation CAND1(INDUCES) 31284535; 33106322 4 21 13 inhibits ubiquitination of spastin at K554; regulates Abscission; midbody localization during cytokinesis -SNAI1 Snail1 C2H2-type zinc finger protein; Transcription factor O95863 6615 20q13.13 human S111-p 6097705 SPPSPAPsSFSSTSV intracellular localization cell motility, altered; transcription, altered 15448698; 19004823 2 0 0 Localization mediated by S107, S111, S115 and S119. -ETS2 Ets-2 DNA-binding; Oncoprotein; Transcription factor P15036 2114 21q22.2 human T72-p 447688 NCELPLLtPCSKAVM activity, induced cell cycle regulation; cell differentiation, induced; apoptosis, inhibited; transcription, induced; transcription, altered 12628005; 15217985; 21441955; 22128184; 8552081 9 0 0 T-cell development; GSK3B transactivation -GRIA2 GluR2 Channel, calcium; Channel, ligand-gated; Membrane protein, integral; Membrane protein, multi-pass P42262 2891 4q32.1 human S880-p 448351 YNVYGIEsVKI____ activity, induced; molecular association, regulation GRIP1(DISRUPTS) 12805550; 26109571 30 1 0 criticcal for induction of cerebellar long-term depression; Synaptic scaling requires association between GluA2 and GRIP1. -Cdk1 CDK1 Cell cycle regulation; EC 2.7.11.22; EC 2.7.11.23; KINASE; Kinase, protein; Motility/polarity/chemotaxis; Protein kinase, CMGC; Protein kinase, Ser/Thr (non-receptor) P39951 54237 20p11 rat T14-p 447608 IEKIGEGtYGVVYKG Pkinase cell cycle regulation 36125973 34 117 1764 -RIGI RIGI EC 3.6.4.13; Hydrolase O95786 23586 9p21.1 human S854-p 17484202 HPKPKQFsSFEKRAK RIG-I_C-RD molecular association, regulation; enzymatic activity, inhibited RIGI(DISRUPTS) 21068236 1 1 0 dephosphorylation of T770, S855, S854 stimulates multimer formation; -SRC Src EC 2.7.10.2; KINASE; Kinase, protein; Oncoprotein; Protein kinase, TK; Protein kinase, tyrosine (non-receptor) P12931 6714 20q11.23 human S51-p 2420700 ADGHRGPsAAFAPAA enzymatic activity, inhibited; intracellular localization; phosphorylation; enzymatic activity, induced cell cycle regulation; chromatin organization, altered; cell motility, induced; cytoskeletal reorganization 29954829; 33388549 3 3 0 inhibits phosphorylation at Y419; induces autophosphorylation of Src at Y419 and phosphorylation of FAK, prevents chromosome breakage in cytokinesis -Mcm3 MCM3 DNA replication; EC 3.6.4.12 P25206 17215 1|1 A4 mouse S732-p 475062 SQEKTDDsQETQDSQ intracellular localization 17244605 2 14 1 Preferentially localized to the soluble nucleoplasmic fraction. -NKX3-1 NKX3-1 DNA-binding; Transcription factor; Tumor suppressor Q99801 4824 8p21.2 human T166-p 28750702 KNLKLTEtQVKIWFQ Homeodomain protein degradation; ubiquitination 23890999 1 0 0 -Exoc8 EXOC8 Vesicle O54924 245709 19q12 rat S28-p 480112 RLYVKQLsQQSDGDR Vps51 molecular association, regulation exocytosis, inhibited Sec5(DISRUPTS); EXOC8(DISRUPTS) 28325821 1 9 4 -H2AC11 H2A.1 DNA-binding P0C0S8 8329 6p22.1 human K13-ub 55610202 QGGKARAkAKTRSSR Histone intracellular localization DNA repair, induced 22980979; 29167269; 32424115 6 0 0 recruiting downstream DNA repair proteins to DNA breaks -Irs1 IRS1 Adaptor/scaffold; Motility/polarity/chemotaxis P35569 16367 1 C5|1 42.0 cM mouse S612-p 447562 DDGYMPMsPGVAPVP protein degradation; molecular association, regulation PIK3C2A(DISRUPTS) 10092613; 15994203 37 7 4 -HRH1 H1R GPCR, family 1; Membrane protein, integral; Membrane protein, multi-pass; Receptor, GPCR P35367 3269 3p25.3 human T142-p 453405 YLKYRTKtRASATIL 7tm_1 receptor desensitization, altered; activity, inhibited 15107581; 15328002 2 0 0 T142 phosphorylation had an inhibitory effect on T140-mediated receptor downregulation. -Kit Kit EC 2.7.10.1; KINASE; Kinase, protein; Membrane protein, integral; Oncoprotein; Protein kinase, TK; Protein kinase, tyrosine (receptor) P05532 16590 5 C3.3|5 39.55 cM mouse Y723-p 448017 SCDSSNEyMDMKPGV PK_Tyr_Ser-Thr molecular association, regulation; enzymatic activity, induced; phosphorylation cell cycle regulation; carcinogenesis, induced; cell growth, induced; signaling pathway regulation PIK3R1(INDUCES) 11090054; 12393643; 16873377; 25438940; 28923937; 7509796 18 5 52 required for required for GIST tumorigenesis; activation of oocyte PI3K signaling; Oocyte awakening; affects JNK and AKT activation/phosphorylation -UBA52-RPS27A-UBB-UBC ubiquitin Ubiquitin-like modifier P62991 mouse K63-ub 486304 LSDYNIQkESTLHLV ubiquitin protein degradation; ubiquitination; enzymatic activity, inhibited; intracellular localization; phosphorylation cell cycle regulation; cell growth, inhibited; apoptosis, induced; transcription, altered; neural plasticity; autophagy, induced; cell differentiation, induced; apoptosis, inhibited; transcription, inhibited RIGI(INDUCES) 16252010; 30886050; 30886105; 31036902; 31074883; 31127032; 31519887; 33976225; 35449295 121 39 155 nuclear localization; promotes NF-?B activation ; Lnczc3h7a promotes the antiviral response to RNA viruses; forms an electrostatic interaction with D129, loss of K133 ubiquitylation or the K133:D129 salt bridge stabilizes IL-1B; suppress production of the proinflammatory cytokines IFN-c and IL-17 by T cells, Treg gene expression and function; Lnczc3h7a noncoding RNA directly binds to the helicase domain of the activated DDX58 protein promoting K63-linked ubiquitination of DDX58; K262 is important for Treg function and stability; CYLD KO augmented short-term but impaired long-term synaptic plasticity, CYLD promotes synapse pruning in a DUB-dependent manner, CYLD directly deubiquitinates Akt and inhibits Akt phosphorylation; osteoclast differentiation, chondrocyte differentiation is impaired in Beclin1 cKO mice; impairs NFAT recruitment and transcription of NFAT-targeted genes -MYOD1 MyoD DNA-binding; RNA splicing; Transcription factor P15172 4654 11p15.1 human K99-ac 458968 RCLLWACkACKRKTT Basic molecular association, regulation; protein conformation cell differentiation, induced; transcription, induced p300(INDUCES); CBP(INDUCES) DNA(INDUCES) 10619020; 18222173 3 1 0 -MRE11 MRE11A Cell cycle regulation; DNA repair, damage; DNA-binding; Deoxyribonuclease P49959 4361 11q21 human R594-me 2344815 RGGSQRGrADTGLET intracellular localization 15970667 1 0 0 localizes in nucleus and associates with nuclear bodies and sites of DNA damage -Kcnj11 Kir6.2 Channel, potassium; Membrane protein, integral; Membrane protein, multi-pass Q61743 16514 7 B3|7 29.66 cM mouse S385-p 2103601 AKPKFSIsPDSLS__ activity, induced; protein conformation 18280666 2 3 0 -OGT OGT EC 2.4.1.255; Glycan Metabolism - O-glycan biosynthesis; O-GlcNAc TRANSFERASE; Transferase O15294 8473 Xq13.1 human S3-p 27713500 _____MAsSVGNVAD enzymatic activity, induced 23395175 1 1 0 -EEF1A2 EEF1A2 Translation; Translation elongation Q05639 1917 20q13.33 human S358-p 27930803 GQISAGYsPVIDCHT GTP_EFTU_D3 protein degradation; molecular association, regulation neural plasticity; cell growth, inhibited; cytoskeletal reorganization; translation, inhibited FLNB(INDUCES); SHRM(DISRUPTS); CAPZB iso1(INDUCES); EEF1G(DISRUPTS); RHOA(INDUCES); EEF1A1(DISRUPTS); VARS(DISRUPTS); ACTG1(DISRUPTS); CARS(DISRUPTS); eEF1B(DISRUPTS); ACTN4(INDUCES) 23608534; 34257105 2 0 0 -KDM1A LSD1 DEMETHYLASE; Demethylase; EC 1.-.-.-; Nuclear receptor co-regulator; Oxidoreductase; Transcription factor O60341 23028 1p36.12 human K117-ac 1883504201 TSRRKRAkVEYREMD protein stabilization; intracellular localization 35970393 1 1 0 cytoplasmic localization -GTF2I GTF2I DNA-binding; Transcription, coactivator/corepressor P78347 2969 7q11.23 human K240-sm 15282907 EMAAVTVkEESEDPD molecular association, regulation carcinogenesis, induced; cell growth, induced HDAC3(DISRUPTS) 25869096 1 2 1 -GRB14 GRB14 Adaptor/scaffold Q14449 2888 2q24.3 human S362-p 31834912 QGRSGCSsQSISPMR molecular association, regulation; phosphorylation INSR(DISRUPTS) 24535599; 28130417 2 2 0 -RRN3 TIF1A Nucleolus; Transcription initiation complex Q9NYV6 54700 16p13.11 human S633-p 448838 SFDTHFRsPSSSVGS cell growth, induced; transcription, induced 21098478 2 0 0 -Ptk2 FAK EC 2.7.10.2; KINASE; Kinase, protein; Protein kinase, TK; Protein kinase, tyrosine (non-receptor) P34152 14083 15 D3|15 33.94 cM mouse Y407-p 447888 IIDEEDTyTMPSTRD enzymatic activity, inhibited; phosphorylation cell cycle regulation; cell motility, altered; cell adhesion, altered; cell growth, altered 17303567 28 13 139 -DOK1 DOK1 Adaptor/scaffold; Motility/polarity/chemotaxis Q99704 1796 2p13.1 human Y146-p 455786 EMLENSLySPTWEGS molecular association, regulation DOK2(INDUCES); DOK1(INDUCES) 16177091 2 1 2 Dok1/Dok2 oligomerization required for ERK1/2 and NFAT activation -Src Src EC 2.7.10.2; KINASE; Kinase, protein; Oncoprotein; Protein kinase, TK; Protein kinase, tyrosine (non-receptor) P05480 20779 2 H1|2 78.35 cM mouse Y418-p 448234 RLIEDNEyTARQGAK PK_Tyr_Ser-Thr activity, induced; protein degradation; receptor internalization, induced; ubiquitination; enzymatic activity, induced; phosphorylation neural plasticity; endocytosis, induced; cell differentiation, induced; cell growth, induced; cell adhesion, induced; transcription, induced; signaling pathway regulation 24526685; 33550461; 34054566; 34307363; 34417202; 34675079; 35536885; 35798842; 36906292 447 103 3046 -Foxo1 FOXO1A DNA-binding; Nuclear receptor co-regulator; Oncoprotein; Transcription factor Q9R1E0 56458 3 C|3 23.19 cM mouse S475-p 478372 PPHNDIMsPVDPGVA FOXO_KIX_bdg molecular association, regulation; intracellular localization transcription, inhibited DUSP6(INDUCES) 22503562; 22848439 3 1 0 -NR5A1 STF-1 Nuclear receptor; Transcription, coactivator/corepressor Q13285 2516 9q33.3 human K72-ac 458974 CPFCRFQkCLTVGMR zf-C4 protein stabilization; intracellular localization transcription, induced 11479297 1 0 0 localization to the cytoplasm -Ccne1 CCNE1 Activator; Cell cycle regulation; Nuclear receptor co-regulator Q61457 12447 7 B3|7 25.35 cM mouse T393-p 447676 PPPSVVLtPPPSSKK protein degradation; ubiquitination; methylation; enzymatic activity, inhibited; activity, inhibited; phosphorylation cell cycle regulation; carcinogenesis, inhibited; transcription, altered; cell differentiation, altered; cell differentiation, induced; DNA repair, altered; apoptosis, inhibited; cell growth, altered 16023597; 18559482; 22405651; 23873023; 24958101 15 11 0 T74A/T393A mutation causes increased Cdk2 kinase activity and stability and regulation by Fbw7. ; using knock-in mutations impaired Fbw7-mediated degradation; required for HSCs' multilineage reconstitution ability, and prevention of chromosome instability (CIN); regulation of oxidative metabolism and ROS production during terminal maturation; Phosphorylation at T74 and T393 causes dephosphorylation of Rb and demethylation of H3K9; T393A affected cyclin E abundance and associated kinase activity. In p53 -/- cells T393A mutation increased proliferation and accelerated tumorigenesis. In p21 null cells T393A mutant caused a defect in proliferation, caused genetic instability, was more abundant, and had higher kinase activity. -MAP3K14 Nik EC 2.7.11.25; KINASE; Kinase, protein; Protein kinase, STE; Protein kinase, Ser/Thr (non-receptor) Q99558 9020 17q21.31 human S820-p 27259015 PSKASQSsRDTLSSG protein degradation 20501937 2 1 0 IKKA-dependent destabilization of Nik -Ppp2ca PPP2CA EC 3.1.3.16; Motility/polarity/chemotaxis; PHOSPHATASE; Protein phosphatase, Ser/Thr (non-receptor) P63331 24672 10q22 rat L309-me 3627520 RRTPDYFl_______ molecular association, regulation PPP2CB(DISRUPTS) 17537547 10 0 0 Demethylated, phosphorylated PPP2CA decreased binding to PPP2CB. -Cdh5 CDH5 Cell adhesion; Membrane protein, integral; Motility/polarity/chemotaxis P55284 12562 8 D3|8 53.04 cM mouse Y731-p 456049 PYDTLHIyGYEGAES CADH_Y-type_LIR receptor internalization, induced; molecular association, regulation apoptosis, induced; cell motility, altered; endocytosis, inhibited CTNNB1(DISRUPTS) 18096689; 24487320; 34914018; 37237266 16 0 1 -Kmt2a MLL Cell cycle regulation; EC 2.1.1.43; METHYLTRANSFERASE; Methyltransferase; Methyltransferase, protein lysine; Oncoprotein; Transcription factor P55200 214162 9 A5.2|9 24.84 cM mouse K1127-ac 11319706 EPLAPPIkPIKPVTR transcription, induced 25751424 1 3 0 -Nr4a2 NR4A2 DNA-binding; Nuclear receptor Q06219 18227 2 C1.1|2 31.66 cM mouse T132-p 487426 SSPPTPStPSFQVQH intracellular localization 25752609 2 0 0 cytoplasmic translocation, required for H2O2-induced necrosis -Pth1r PTHR GPCR, family 2; Membrane protein, integral; Membrane protein, multi-pass; Receptor, GPCR P25961 56813 8q32 rat S491-p 452061 KRKARSGsSSYSYGP receptor internalization, altered; activity, inhibited 11773434; 18577695 5 4 0 -PLCG2 PLCG2 Carbohydrate Metabolism - inositol phosphate; EC 3.1.4.11; Motility/polarity/chemotaxis; Phospholipase P16885 5336 16q23.3 human Y753-p 447940 ERDINSLyDVSRMYV molecular association, regulation; enzymatic activity, induced LYN(INDUCES) 12780340; 15184383; 30344948 10 11 270 intramolecular tyrosine-phosphorylation and Rac mediated activation -Gja1 GJA1 Channel, misc.; Membrane protein, integral; Membrane protein, multi-pass; Motility/polarity/chemotaxis P08050 24392 20q11 rat S282-p 448854 TAPLSPMsPPGYKLV molecular association, regulation; intracellular localization; activity, inhibited apoptosis, induced; apoptosis, inhibited GJA1(INDUCES) 23922949; 26841867; 30770876; 34931018; 9535909 42 7 1 -TTK TTK Cancer Testis Antigen (CTA); EC 2.7.12.1; KINASE; Kinase, protein; Protein kinase, Other; Protein kinase, dual-specificity (non-receptor) P33981 7272 6q14.1 human S742-p 4145509 QQIINQIsKLHAIID Pkinase enzymatic activity, induced 18680479 1 0 0 in vitro -NFKB2 NFkB-p100 DNA-binding; Oncoprotein; Transcription factor Q00653 4791 10q24.32 human K90-sm 3055611 CNYEGPAkIEVDLVT RHD_DNA_bind protein processing; phosphorylation signaling pathway regulation 18617892 1 0 0 activation of alternative NF-kB pathway -Klc1 KLC1 Microtubule-binding; Motor P37285 171041 6q32 rat S460-p 477826 YKACKVDsPTVTTTL molecular association, regulation CLSTN1(DISRUPTS) 21385839 3 41 3 -CERT1 COL4A3BP EC 2.7.11.9; KINASE; Kinase, protein; Lipid-binding; Protein kinase, Ser/Thr (non-receptor); Protein kinase, atypical Q9Y5P4 10087 5q13.3 human S132-p 483985 SSLRRHGsMVSLVSG molecular association, regulation; intracellular localization; enzymatic activity, inhibited; protein conformation; activity, inhibited exocytosis, altered COL4A3BP(INDUCES) 17442665; 17591919; 19005213; 21285358; 28652409; 29541394; 29848549 7 12 13 reduced PtdIns(4)P binding affinity as well as low ceramide transfer activity, E494R/N495K/P535R/E537K mutations, recovery of both PtdIns(4)P binding and ceramide transfer activity.; intracellular GPBP multimerization; regulates PI(4)P uptake; inhibited exportation; CERT SRM interacts with the CERT PH domain -ROCK1 ROCK1 EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, AGC; Protein kinase, Ser/Thr (non-receptor) Q13464 6093 18q11.1 human T1334-p 1210778 ASPRTLStRSTANQS intracellular localization cytoskeletal reorganization 21685893 1 2 4 inhibits apical constriction -ALDH1A1 ALDH1A1 Apoptosis; Cofactor and Vitamin Metabolism - retinol; EC 1.2.1.36; GAP; GAP, Ras; Oxidoreductase P00352 216 9q21.13 human T493-p 63070900 YTEVKTVtVKISQKN protein stabilization; ubiquitination; intracellular localization; protein conformation; enzymatic activity, induced carcinogenesis, induced; cell motility, induced; cell growth, induced; transcription, induced ALDH1A1(DISRUPTS) 28193222 1 0 0 inhibits ubiquitination, induces drug resistance, T267 site ALDHA1A1 increases enzymatic activity, oligomers dissociate to the monomeric form -Camk1 CAMK1A EC 2.7.11.17; KINASE; Kinase, protein; Protein kinase, CAMK; Protein kinase, Ser/Thr (non-receptor) Q63450 171503 4q42 rat T177-p 448527 DPGSVLStACGTPGY Pkinase molecular association, regulation NUMBL(INDUCES); SYN1(INDUCES); CREB iso1(INDUCES) 16105844 10 6 7 -SLN sarcolipin Endoplasmic reticulum; Membrane protein, integral P42532 100009246 rabbit T5-p 459214 ___MERStRELCLNF Sarcolipin molecular association, regulation SERCA2(INDUCES) 16461894 6 0 0 -NDUFB6 NDUFB6 EC 1.6.5.3; EC 1.6.99.3; Energy Metabolism - oxidative phosphorylation; Membrane protein, integral; Mitochondrial; Oxidoreductase O95139 4712 9p21.1 human T5-p 33402202 ___MTGYtPDEKLRL NDUF_B6 activity, induced cell cycle regulation 24746669 1 1 0 increases mitochondrial respiration for G/2M transition -SP7 osterix C2H2-type zinc finger protein; DNA-binding; Transcription factor Q8TDD2 121340 12q13.13 human K307-ac 56714900 GCGKVYGkASHLKAH zf-C2H2 protein stabilization; molecular association, regulation cell differentiation, induced; transcription, induced DNA(INDUCES) 27250035 1 0 0 -NR1H4 NR1H4 DNA-binding; Nuclear receptor Q96RI1 9971 12q23.1 human K227-ac 12159006 KRLRKNVkQHADQTV protein stabilization; molecular association, regulation transcription, inhibited RXRA(DISRUPTS) DNA(DISRUPTS) 19883617 1 1 0 -CAPZA1 CAPZA1 Actin-binding; Motility/polarity/chemotaxis P52907 829 1p13.2 human S126-p 1870026100 SWRESCDsALRAYVK F-actin_cap_A cell motility, induced; cell adhesion, induced; cytoskeletal reorganization 32771000 1 1 0 -Anxa2 ANXA2 Calcium-binding; Lipid-binding; Motility/polarity/chemotaxis P07356 12306 9 C|9 38.58 cM mouse K10-sm 40493900 TVHEILCkLSLEGDH cytoskeletal reorganization 25775977 1 0 0 -YAP1 YAP1 Oncoprotein; Transcription, coactivator/corepressor P46937 10413 11q22.1 human S109-gl 1873529902 KSHSRQAsTDAGTAG activity, induced; protein stabilization; molecular association, regulation; intracellular localization; phosphorylation carcinogenesis, induced; cell motility, induced; transcription, induced LATS2(DISRUPTS); LATS1(DISRUPTS) 34155345 1 0 0 inhibits YAP1-S127 phosphorylation -FPR2 FPR2 GPCR, family 1; Membrane protein, integral; Membrane protein, multi-pass; Motility/polarity/chemotaxis; Receptor, GPCR P25090 2358 19q13.41 human S237-p 3176602 KKGMIKSsRPLRVLT 7tm_1 receptor desensitization, altered 11063592 1 0 0 downregulates PLA2 and PLD activation -EGFR EGFR EC 2.7.10.1; KINASE; Kinase, protein; Membrane protein, integral; Oncoprotein; Protein kinase, TK; Protein kinase, tyrosine (receptor) P00533 1956 7p11.2 human S768-p 452119 DEAYVMAsVDNPHVC PK_Tyr_Ser-Thr enzymatic activity, inhibited 29695735 6 0 0 decrease ligand-independent phosphorylation of both the activation loop (Y845) and the C-terminal tail (Y1197) compared to wild-type and oncogenic (S768I) EGFR -Trpc6 TRPC6 Channel, cation; Membrane protein, integral; Membrane protein, multi-pass Q61143 22068 9 A1|9 2.46 cM mouse T487-p 27839400 RQLFRMKtSCFSWME Ion_trans; TM activity, induced 23529130 1 0 0 Regulates channel activity induced by AVP receptor stimulation -Myod1 MyoD DNA-binding; RNA splicing; Transcription factor P10085 17927 7 B3|7 30.03 cM mouse S200-p 40684505 SGDSDASsPRSNCSD Myf5 protein degradation; molecular association, regulation; intracellular localization cell differentiation, inhibited; cell cycle regulation; transcription, altered HDAC1(INDUCES); PCAF(DISRUPTS) DNA(DISRUPTS) 10082583; 14749395; 17014844; 27823936; 9710583 8 1 0 protein stability alone contributes to the enhanced activity of S200A mutant -SPHK1 SPHK1 ACETYLTRANSFERASE; Acetyltransferase; EC 2.3.1.-; EC 2.7.1.91; Kinase, lipid; Lipid Metabolism - sphingolipid Q9NYA1 8877 17q25.1 human S225-p 460682 VGSKTPAsPVVVQQG molecular association, regulation; intracellular localization; phosphorylation; enzymatic activity, induced carcinogenesis, altered; apoptosis, inhibited; cell growth, altered ITGB3(INDUCES); PECAM-1(INDUCES) Other(INDUCES) 14532121; 15623571; 16243846; 18852266; 19815712; 21075214 14 8 0 -HMGN1 HMGN1 DNA-binding; Nuclear receptor co-regulator P05114 3150 21q22.2 human K27-ac 458845 RSARLSAkPPAKVEA HMG14_17 molecular association, regulation DNA(DISRUPTS) 10753971 1 2 0 -MYH9 MYH9 Actin-binding; Motility/polarity/chemotaxis; Motor P35579 4627 22q12.3 human S1808-p 2482304 VKSKYKAsITALEAK Myosin_tail_1 intracellular localization cytoskeletal reorganization 18394644 1 4 0 -KMT2E MLL5 Cell cycle regulation; EC 2.1.1.43; METHYLTRANSFERASE; Methyltransferase; Methyltransferase, protein lysine; Transcription, coactivator/corepressor Q8IZD2 55904 7q22.3 human T912-p 14645300 PMDPSFAtPPRIKSD intracellular localization cell cycle regulation 20439461 1 0 2 -ARHGEF2 ARHGEF2 GEF; GEF, Rac/Rho; Motility/polarity/chemotaxis Q92974 9181 1q22 human S886-p 451365 PVDPRRRsLPAGDAL molecular association, regulation; enzymatic activity, inhibited; activity, inhibited; phosphorylation cell differentiation, inhibited; cell cycle regulation; cytoskeletal reorganization; signaling pathway regulation 14-3-3 beta(INDUCES); 14-3-3 zeta(INDUCES) 14970201; 15827085; 17488622; 33762326 12 47 145 regulates GEF-H1/RhoA/ROCK pathway -Ets1 Ets-1 DNA-binding; Motility/polarity/chemotaxis; Oncoprotein; Transcription factor P27577 23871 9 A4|9 17.97 cM mouse S285-p 449318 QRVPSYDsFDYEDYP Ets1_N_flank molecular association, regulation; acetylation; intracellular localization transcription, inhibited DNA(DISRUPTS) 30865889 6 10 56 induce acetylation of FOXO1 and suppress gluconeogenesis -H1-4 H1E DNA-binding P10412 3008 6p22.2 human T146-p 458356 KKATGAAtPKKSAKK cell cycle regulation; cell growth, altered 24601643; 24873882 5 11 8 -MAFA MAFA DNA-binding; Oncoprotein; Transcription factor; Tumor suppressor Q8NHW3 389692 8q24.3 human K32-sm 6124705 DLMKFEVkKEPPEAE transcription, inhibited 19029092 2 0 0 -CHN2 ARHGAP3 GAP; GAP, Rac/Rho P52757 1124 7p14.3 human Y153-p 473503 KMTTNPIyEHIGYAT intracellular localization; activity, inhibited cytoskeletal reorganization 19201754 1 2 146 -Hdac4 HDAC4 DEACETYLASE; Deacetylase; EC 3.5.1.98; Hydrolase; Nuclear receptor co-regulator; SUMO LIGASE Q99P99 363287 9q36 rat S630-p 448490 RPLSRAQsSPASATF molecular association, regulation transcription, induced AML3(DISRUPTS) 24904057 11 40 71 -KCNK18 KCNK18 Channel, ligand-gated; Channel, potassium; Membrane protein, integral; Membrane protein, multi-pass Q7Z418 338567 10q25.3 human S267-p 13383301 RLSYSIIsNLDEVGQ intracellular localization; activity, inhibited transcription, inhibited 30327410 3 0 0 -GP1BA GPIbA Cell adhesion; Cell surface; Membrane protein, integral P07359 2811 17p13.2 human S601-p 11333102 WLLFLRGsLPTFRSS molecular association, regulation FLNA(DISRUPTS); 14-3-3 zeta(INDUCES); VWF(INDUCES) 19875727 1 1 0 -CXCR4 CXCR4 GPCR, family 1; Membrane protein, integral; Membrane protein, multi-pass; Receptor, GPCR P61073 7852 2q22.1 human K331-ub 12324739 SSLKILSkGKRGGHS protein degradation 24489825 1 0 1 -DTD1 DTD1 DNA replication; EC 3.1.-.-; Hydrolase Q8TEA8 92675 20p11.23 human S194-p 3072143 TPRKEDRsASSGAEG molecular association, regulation cell cycle regulation; cell growth, induced MCM7(INDUCES); MCM3(DISRUPTS) 25258324 1 13 0 decreases DTD1 incorporation into HMW, supports DNA replication initiation -MDM2 MDM2 EC 6.3.2.-; EC 6.3.2.19; Inhibitor; Ligase; NEDDYLATION LIGASE; Neddylation Ligase; Nucleolus; Oncoprotein; UBIQUITIN LIGASE; Ubiquitin conjugating system; Ubiquitin ligase Q00987 4193 12q15 human S407-p 450263 SSSIIYSsQEDVKEF molecular association, regulation; enzymatic activity, inhibited; protein conformation p53(DISRUPTS) 21986495 2 3 0 oligomerization inhibited -STIM1 STIM1 Calcium-binding; Endoplasmic reticulum; Membrane protein, integral Q13586 6786 11p15.4 human S628-p 9257903 SPDPDTPsPVGDSRA molecular association, regulation; intracellular localization cytoskeletal reorganization EB1(DISRUPTS) 22748319 1 10 5 phosphorylation dissociates STIM1 from EB1 during mitosis, and excludes ER from the mitotic spindle -MAP3K9 MLK1 EC 2.7.11.25; KINASE; Kinase, protein; Protein kinase, Ser/Thr (non-receptor); Protein kinase, TKL P80192 4293 14q24.2 human T312-p 455217 TKMSAAGtYAWMAPE Pkinase activity, induced 15610029 1 0 0 -Irf7 IRF7 DNA-binding; Transcription factor P70434 54123 7|7 F5 mouse S437-p 486437 SSLGLCLsSTNSLYE transcription, induced DNA(INDUCES) 15743772; 33976210 3 0 0 -GATA3 GATA3 Transcription factor P23771 2625 10p14 human T156-p 33638003 HLFTFPPtPPKDVSP protein degradation; ubiquitination FBXW7(INDUCES) 24820417 1 0 0 -FEN1 FEN1 DNA repair, damage; DNA-binding; Deoxyribonuclease; EC 3.1.-.-; Nuclear receptor co-regulator; Nucleolus; Ribonuclease P39748 2237 11q12.2 human K380-ac 460620 AGKFKRGk_______ molecular association, regulation; enzymatic activity, inhibited DNA(DISRUPTS) 11430825 1 1 0 -Sik3 QSK EC 2.7.11.1; KINASE; Kinase, protein; Motility/polarity/chemotaxis; Protein kinase, CAMK; Protein kinase, Ser/Thr (non-receptor) Q6P4S6 70661 9|9 A5.2 mouse T221-p 456036 TPGQLLKtWCGSPPY Pkinase enzymatic activity, inhibited; phosphorylation; enzymatic activity, induced transcription, altered; signaling pathway regulation 35997995; 36477534 8 17 14 induces HDAC4 phosphorylation and thus induces QSK?HDAC4 signalling -Bcl2l11 BIM Apoptosis O54918 12125 2|2 F1 mouse S114-p 449072 DKSTQTPsPPCQAFN protein stabilization; molecular association, regulation apoptosis, induced Bcl-2(INDUCES); Bcl-xL(INDUCES) 23832115 5 6 0 -G6PD G6PD Carbohydrate Metabolism - pentose phosphate pathway; Cell development/differentiation; EC 1.1.1.49; Other Amino Acids Metabolism - glutathione; Oxidoreductase P11413 2539 Xq28 human K386-ac 11320999 DIFHQQCkRNELVIR G6PD_C enzymatic activity, altered 37798264 1 2 0 -Myod1 MyoD DNA-binding; RNA splicing; Transcription factor P10085 17927 7 B3|7 30.03 cM mouse T115-p 452044 ADRRKAAtMRERRRL HLH activity, inhibited 17761773 2 0 0 regulates slow to fast MyHC fibre type transformation -Myl12b MRLC2 Contractile P18666 50685 9q38 rat T19-p 448596 KKRPQRAtSNVFAMF protein conformation exocytosis, altered 18283106 36 50 282 -TBCB TBCB Chaperone; Cytoskeletal; Motility/polarity/chemotaxis Q99426 1155 19q13.12 human S128-p 455785 VRSFLKRsKLGRYNE cytoskeletal reorganization 15831477; 18048340 2 0 0 -FIS1 FIS1 Membrane protein, integral; Mitochondrial Q9Y3D6 51024 7q22.1 human Y38-p 1875830300 SKSTQFEyAWCLVRS Fis1_TPR_N carcinogenesis, induced; cell motility, induced; cytoskeletal reorganization DRP1(INDUCES) 34848680 1 1 0 recruits Drp1 to mitochondria -SP1 SP1 C2H2-type zinc finger protein; DNA-binding; Transcription factor P08047 6667 12q13.13 human S641-gl 5262504 GKVYGKTsHLRAHLR zf-C2H2 transcription, induced 18513490 2 1 0 -ABL1 Abl EC 2.7.10.2; KINASE; Kinase, protein; Oncoprotein; Protein kinase, TK; Protein kinase, tyrosine (non-receptor) P00519 25 9q34.12 human T735-p 450291 DTEWRSVtLPRDLQS molecular association, regulation; intracellular localization; enzymatic activity, induced apoptosis, induced; apoptosis, inhibited 14-3-3 beta(INDUCES); 14-3-3 beta(DISRUPTS) 15696159; 16888623; 18794806; 19643477 5 2 1 -PPP1CA PPP1CA EC 3.1.3.16; Nucleolus; PHOSPHATASE; Protein phosphatase, Ser/Thr (non-receptor) P62136 5499 11q13.2 human T320-p 448686 NPGGRPItPPRNSAK enzymatic activity, inhibited; activity, inhibited; phosphorylation cell cycle regulation; cell differentiation, altered; cytoskeletal reorganization 12202491; 17202132; 21996745; 35081344 24 43 98 inhibits MAP4 phosphorylation -Bcl11b Bcl-11B C2H2-type zinc finger protein; Nuclear receptor co-regulator; Transcription regulation Q99PV8 58208 12 F1|12 59.1 cM mouse S277-p 14159419 GPETVAQsPLMNFLG molecular association, regulation SENP1(INDUCES) 22700985 0 6 1 -OGFOD1 OGFOD1 EC 1.14.11.-; Oxidoreductase Q8N543 55239 16q13 human S256-p 1874115106 FEPPIPRsPHIPQDH carcinogenesis, induced; cell motility, induced; cell growth, induced; transcription, induced 34298635 1 0 0 -ADORA2A ADORA2A GPCR, family 1; Membrane protein, integral; Membrane protein, multi-pass; Receptor, GPCR P29274 135 22q11.23 human S374-p 13417800 SGGSAQEsQGNTGLP molecular association, regulation DRD2(INDUCES) 20197060 1 0 0 -IRAK1 IRAK1 EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, Ser/Thr (non-receptor); Protein kinase, TKL P51617 3654 Xq28 human K134-ub 2134713 AEAWSPRkLPSSAST protein degradation transcription, induced; signaling pathway regulation 18326498; 29038250 3 0 0 activation of TLR9 ligand-induced inflammatory signaling -Chrnb1 nAChRB1 Channel, cation; Channel, ligand-gated; Membrane protein, integral; Membrane protein, multi-pass P09690 11443 11 B3|11 42.87 cM mouse Y390-p 2562301 WGRGTDEyFIRKPPS Neur_chan_memb molecular association, regulation RAPsyn(INDUCES) 18987183 3 1 4 increases nAchRB1 clustering -Vim Vimentin Cytoskeletal; Motility/polarity/chemotaxis P20152 22352 2 A1|2 10.04 cM mouse S72-p 449026 SSAVRLRsSVPGVRL Filament_head cytoskeletal reorganization 12458200 21 34 40 -CASP8 CASP8 iso4 Apoptosis; EC 3.4.22.61; Protease Q14790-4 841 2q33.1 human Y465-p 1032277 TILTEVNyEVSNKDD Peptidase_C14 enzymatic activity, inhibited; enzymatic activity, induced apoptosis, inhibited 27101103 2 2 0 Src activated by CASP8 Y397 and Y465 phosphorylation; prevents its cleavage -PECAM1 PECAM-1 Cell adhesion; Cell development/differentiation; Membrane protein, integral; Motility/polarity/chemotaxis P16284 5175 17q23.3 human Y690-p 448759 PLNSDVQyTEVQVSS activity, induced; molecular association, regulation cytoskeletal reorganization; cell adhesion, altered SHP-2(INDUCES) 10704309; 11927609; 12535670; 15201144; 9312087 9 0 44 -MYC Myc DNA-binding; Nucleolus; Oncoprotein; Transcription factor P01106 4609 8q24.21 human K163-sm 40724405 AAKLVSEkLASYQAA Myc_N protein degradation; ubiquitination transcription, inhibited 25895136 1 2 0 -Espl1 separase EC 3.4.22.49; Protease P60330 105988 15|15 F3 mouse S1121-p 447673 IQSSVNSsPVLKTKP molecular association, regulation; enzymatic activity, inhibited; activity, inhibited cell cycle regulation; chromatin organization, altered; cell growth, inhibited; cell growth, induced; apoptosis, inhibited; cell growth, altered CCNB1(INDUCES) 16030258; 18232736; 19124608; 22814604; 36450246 11 10 0 -Prkaa2 AMPKA2 Autophagy; EC 2.7.11.1; EC 2.7.11.27; EC 2.7.11.31; KINASE; Kinase, protein; Protein kinase, CAMK; Protein kinase, Ser/Thr (non-receptor) Q8BRK8 108079 4|4 C6 mouse S491-p 450432 STPQRSCsAAGLHRA AdenylateSensor enzymatic activity, inhibited 26797128 13 12 2 -Dvl2 DVL2 Adaptor/scaffold; Motility/polarity/chemotaxis Q60838 13543 11 B3|11 42.96 cM mouse S143-p 7320089 FHPNVSSsHENLEPE Dishevelled molecular association, regulation carcinogenesis, induced; cell differentiation, induced; transcription, induced; signaling pathway regulation DVL2(INDUCES) 33637566 4 3 1 Wnt/?-catenin pathway -VAV1 VAV1 GEF; GEF, Rac/Rho; Motility/polarity/chemotaxis; Oncoprotein P15498 7409 19p13.3 human Y844-p 454086 VEEDYSEyC______ carcinogenesis, altered; cell growth, altered 20457609 1 17 467 -SKI SKI Cell cycle regulation; Oncoprotein; Transcription, coactivator/corepressor; Ubiquitin conjugating system P12755 6497 1p36.33-p36.32 human T458-p 11279400 QPRKRKLtVDTPGAP protein degradation transcription, altered 19875456 1 0 2 reduces the activation of TGF-beta signaling -FOXC2 FOXC2 Apoptosis; Cell development/differentiation; DNA-binding; Transcription factor Q99958 2303 16q24.1 human S251-p 7322587 AASTPAGsPDGSLPE molecular association, regulation transcription, altered DNA(INDUCES) 23878394 1 1 0 implicated in vascular remodeling in vivo -BACE1 BACE EC 3.4.23.46; Membrane protein, integral; Protease P56817 23621 11q23.3 human K285-ac 478259 CKEYNYDkSIVDSGT Asp protein stabilization; intracellular localization 17425515 1 1 0 regulates translocation through secretory pathway -NRF1 NRF1 DNA-binding; Transcription factor Q16656 4899 7q32.2 human T259-p 23255803 QKQRVSWtQALRTIV Nrf1_DNA-bind molecular association, regulation; intracellular localization signaling pathway regulation NRF1(INDUCES) 30642892 1 0 1 -BRCA1 BRCA1 EC 6.3.2.-; Nuclear receptor co-regulator; Transcription, coactivator/corepressor; Tumor suppressor; UBIQUITIN LIGASE; Ubiquitin conjugating system; Ubiquitin ligase P38398 672 17q21.31 human S1280-p 767901 QVILAKAsQEHHLSE intracellular localization 17531442 2 6 0 S1143 and S1280 phosphorylation contributes to BRCA1 recruitment to MMTS-induced foci. -Rbm7 RBM7 RNA-binding Q9CQT2 67010 9|9 A5.3 mouse S136-p 453069 QMVQRSFsSPEDYQR molecular association, regulation RNA(DISRUPTS) 25525152 2 50 103 -FBXL20 FBXL20 UBIQUITIN LIGASE; Ubiquitin ligase Q96IG2 84961 17q12 human T417-p 467016 HAYFAPVtPPPSVGG protein degradation; molecular association, regulation carcinogenesis, inhibited; cell growth, inhibited; apoptosis, induced FBXO31(INDUCES) 34587475 1 54 61 -Gfap GFAP Cytoskeletal P03995 14580 11 E1|11 66.48 cM mouse S8-p 449618 MERRRITsARRSYAS Filament_head molecular association, regulation autophagy, inhibited 14-3-3 gamma(INDUCES) 17032734; 33048163 9 0 0 -H4c2 H4 DNA-binding P62804 295277 rat K8-ac 458959 SGRGKGGkGLGKGGA transcription, induced 19909801 85 21 529 -ATXN3 ataxin-3 DEUBIQUITINASE; DNA repair, damage; EC 3.4.19.12; Protease; Transcription regulation; Ubiquitin-specific protease P54252 4287 14q32.12 human S347-p 9441000 LQAAVTMsLETVRND UIM activity, induced; protein stabilization; intracellular localization transcription, altered 19542537 1 0 0 -FBXO3 FBXO3 UBIQUITIN LIGASE; Ubiquitin conjugating system; Ubiquitin ligase Q9UK99 26273 11p13 human T82-p 1871994100 WKSLFIDtYSDVGRY protein degradation; protein stabilization carcinogenesis, induced; cell motility, induced 33626035 2 0 0 induces protein stabilization of FBXO3 and protein degradation of ?Np63a -BACE1 BACE EC 3.4.23.46; Membrane protein, integral; Protease P56817 23621 11q23.3 human S498-p 450178 DDFADDIsLLK____ sumoylation; protein degradation; intracellular localization; enzymatic activity, induced PACS-1(INDUCES); Rab7(DISRUPTS) 11278841; 15615712; 24305806; 28946017; 37286480 7 4 0 inhibits sumoylation; decreased TGN localization -WASF2 WAVE2 Actin-binding; Motility/polarity/chemotaxis Q9Y6W5 10163 1p36.11 human S308-p 12626400 PPAPPLGsPPGPKPG molecular association, regulation cell motility, altered; cytoskeletal reorganization 21419341 1 11 0 regulates WRC (WAVE2 regulatory complex) interaction with Arp2/3 and lamellipodial protrusion -FLNC FLNC Cytoskeletal; Motility/polarity/chemotaxis Q14315 2318 7q32.1 human S2624-p 15403523 SSSSRGSsYSSIPKF protein stabilization 28028127 1 15 0 -CBY1 CBY1 Transcription regulation Q9Y3M2 25776 22q13.1 human S20-p 2850009 TPPRKSAsLSNLHSL Chibby molecular association, regulation; intracellular localization transcription, altered 14-3-3 zeta(INDUCES) 18573912; 25909186 2 24 0 interaction of PGEA1 with 14-3-3 zeta contributes to the formation of trimolecular complex with CTNNB1 -SFPQ PSF Nuclear receptor co-regulator; RNA splicing; RNA-binding P23246 6421 1p34.3 human T687-p 449362 PRGMGPGtPAGYGRG molecular association, regulation BCLAF1(INDUCES); Trap150(INDUCES) 20932480 1 34 58 TRAP150-PSF interaction regulates CD45 splicing by blocking PSF from interacting with CD45 pre-mRNA in resting T cells -Ctnnb1 CTNNB1 Actin-binding; Cell adhesion; Motility/polarity/chemotaxis; Nuclear receptor co-regulator; Oncoprotein; Transcription factor Q9WU82 84353 8q32 rat S675-p 457120 QDYKKRLsVELTSSL protein stabilization; intracellular localization cell cycle regulation; autophagy, induced; cell motility, induced; cell growth, induced; transcription, induced; signaling pathway regulation 33518533; 35012644 40 55 17 induces PKA/?-catenin/CTH pathway -Ywhab 14-3-3 beta Adaptor/scaffold P35213 56011 3q42 rat T143-p 3136106 SGDNKQTtVSNSQQA 14-3-3 molecular association, regulation RAF1(DISRUPTS); PKCZ(DISRUPTS) 10620507 1 0 0 -Zfp36 TTP DNA-binding; RNA-binding P22893 22695 7 A3-B1|7 16.72 cM mouse S316-p 451153 LPIFNRIsVSE____ molecular association, regulation; intracellular localization RNA stability, induced; transcription, induced 14-3-3 beta(INDUCES); NOT1(DISRUPTS) 34090459 2 11 0 -H4c2 H4 DNA-binding P62804 295277 rat K16-ac 458960 GLGKGGAkRHRKVLR transcription, induced 19909801 106 26 531 -EIF6 EIF6 Nucleolus; Translation; Translation initiation P56537 3692 20q11.22 human S235-p 450271 QPSTIATsMRDSLID activity, induced; molecular association, regulation; intracellular localization carcinogenesis, induced; translation, altered; translation, induced Other(DISRUPTS) 14654845; 21665150; 32703900 3 5 2 -Nrip1 RIP140 Nuclear receptor co-regulator; Transcription, coactivator/corepressor Q8CBD1 268903 16|16 C3.1 mouse K158-ac 459035 QQIRQSLkEQGYALS NRIP1_repr_1 activity, induced; intracellular localization transcription, inhibited 15879431; 18655826 1 2 0 enhanced fat accumulation in differentiated adipocytes -Ppp2r5b PPP2R5B Motility/polarity/chemotaxis; Protein phosphatase, regulatory subunit Q6PD28 225849 19|19 A mouse S48-p 23134678 PRRSHSSsQFRYQSN molecular association, regulation; phosphorylation PPP2CA(INDUCES); PPP2R5B(INDUCES) 21329884 1 2 3 PPP2R2R5B phosphorylation by CLK2 is required for the PPP2CA-AKT complex; induces AKT dephosphorylation -MYBBP1A MYBBP1A DNA replication; DNA-binding; Nucleolus; RNA-binding Q9BQG0 10514 17p13.2 human S1303-p 3210687 ARKKARLsLVIRSPS cell cycle regulation 20177074 2 21 2 -Cnr1 CNR1 GPCR, family 1; Membrane protein, integral; Membrane protein, multi-pass; Receptor, GPCR P47746 12801 4 A5|4 16.28 cM mouse S469-p 22342303 MSVSTDTsAEAL___ receptor desensitization, induced 22014214 1 0 0 -Nedd4l NEDD4L EC 6.3.2.-; EC 6.3.2.19; Ligase; UBIQUITIN LIGASE; Ubiquitin conjugating system; Ubiquitin ligase Q8CFI0 83814 18|18 E1 mouse S371-p 453438 SSRLRSCsVTDTVAE protein stabilization; molecular association, regulation; intracellular localization cell differentiation, induced; translation, induced 14-3-3 epsilon(INDUCES) 21900244; 24705297; 33064840 14 17 59 -Map3k5 ASK1 EC 2.7.11.25; KINASE; Kinase, protein; Protein kinase, STE; Protein kinase, Ser/Thr (non-receptor) O35099 26408 10|10 A3 mouse S1036-p 1984030 DENFEDHsAPPSPEE enzymatic activity, inhibited; phosphorylation 35438255 0 21 0 inhibits p38 phosphorylation -MYH9 MYH9 Actin-binding; Motility/polarity/chemotaxis; Motor P35579 4627 22q12.3 human S1916-p 451181 AMNREVSsLKNKLRR Myosin_tail_1 molecular association, regulation; intracellular localization carcinogenesis, induced; exocytosis, induced; cell motility, induced; cell adhesion, induced; cytoskeletal reorganization; cell adhesion, altered HBXIP(INDUCES) 25544611; 28053086; 29208598; 36970214 11 3 8 -H3C1 H3 DNA-binding P68431 8350 6p22.2 human K9-m2 459006 RTKQTARkSTGGKAP Histone molecular association, regulation; methylation; enzymatic activity, inhibited; intracellular localization cell cycle regulation; cell differentiation, inhibited; carcinogenesis, induced; carcinogenesis, inhibited; cell growth, inhibited; cell motility, induced; cell motility, inhibited; transcription, induced; transcription, altered; cell differentiation, induced; cell growth, induced; chromatin organization, altered; transcription, inhibited CAF-1A(INDUCES); UHRF2(INDUCES); CHD-4(INDUCES); KRTAP1-1(INDUCES); PHF8(INDUCES); TIF1B(INDUCES); HP1 alpha(INDUCES); ERCC6(INDUCES); requiem(INDUCES); ANP32B(INDUCES); ANP32A(INDUCES); CBX1(INDUCES); HP1BP3(INDUCES) DNA(INDUCES) 16079795; 16732292; 16732293; 16858404; 16982742; 17980151; 18628788; 18701507; 18835819; 19022177; 19187761; 19337993; 19460472; 19477956; 19546172; 19624289; 19706462; 19787243; 19889207; 20080105; 20152814; 20346720; 20421419; 20439491; 20546607; 20547755; 20548336; 21059703; 21532585; 23423566; 23518351; 25535969; 25548279; 25749385; 25789554; 27694900; 28672915; 30377265; 35293595; 36872368; 37749225 119 21 0 H3K9m3 leads to heterochromatin and proliferation; transcriptional repression; AMPKA2 induced PHF2-S655 phosphorylation suppresses cell migration, invasion, and metastasis. -ELMO1 ELMO1 Cytoskeletal; Motility/polarity/chemotaxis Q92556 9844 7p14.2-p14.1 human Y216-p 455872 VLNSHDLyQKVAQEI ELMO_ARM molecular association, regulation; intracellular localization NCK1(INDUCES); RHOG(INDUCES) 24928514 3 2 0 Nck1 enhances ELMO1 and RhoG interaction and promotes Rac1 activity; localization of ELMO1 to the plasma membrane -HIPK2 HIPK2 EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, CMGC; Protein kinase, Ser/Thr (non-receptor) Q9H2X6 28996 7q34 human K32-ub 3059900 FCSVKKLkIEPSSNW protein degradation 18536714 1 0 0 -Mef2d MEF2D DNA-binding; Transcription factor O89038 81518 2q34 rat S153-p 10359102 VPVSNQSsMQFSNPS HJURP_C activity, inhibited apoptosis, altered; transcription, inhibited 19801631 1 0 0 -CTPS1 CTPS EC 6.3.4.2; Ligase; Motility/polarity/chemotaxis; Nucleotide Metabolism - pyrimidine P17812 1503 1p34.2 human T455-p 473570 MRLGKRRtLFQTKNS GATase enzymatic activity, inhibited cell growth, altered 17189248; 17463002 2 0 0 -PSRC1 PSRC1 Q6PGN9 84722 1p13.3 human S223-p 18963101 RAAKLRVsGSGEFVG cytoskeletal reorganization 21473853 1 1 0 -RPS6KA1 p90RSK EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, AGC; Protein kinase, Ser/Thr (non-receptor); Translation Q15418 6195 1p36.11 human K335-sm 1881518211 KLYRREIkPPFKPAV molecular association, regulation; phosphorylation EIF4B(INDUCES) 34871326 1 0 0 SUMO-SIM interaction contributes to RSK1-eIF4B association; sites incudinge IF4B (Ser 422 and Ser 425, 29.91 fold), SETD1A (Ser 915 and Ser 916, 25.76 fold), LMNA (Ser 404 and Ser 406, 16.42 fold), ZNF 217 (Ser 975, 13.27 fold); SUMOylation is required for is required for replication and virus production of KSHV; affect eIF4B phosphorylation by RSK1 in vitro; SUMOylation affects the phosphorylation levels of its substrates -VHL VHL Tumor suppressor; UBIQUITIN LIGASE; Ubiquitin ligase P40337 7428 3p25.3 human K171-sm 13258709 QVVRSLVkPENYRRL VHL_C sumoylation; protein stabilization; molecular association, regulation; intracellular localization cell cycle regulation; carcinogenesis, induced; carcinogenesis, inhibited; cell motility, induced; cell growth, induced; transcription, induced; transcription, inhibited VHL(INDUCES); Alix(INDUCES); VAMP8(INDUCES); TCEB1(DISRUPTS) 20300531; 21652636 2 1 0 -DBN1 DBN1 Actin-binding; Cytoskeletal; Motility/polarity/chemotaxis Q16643 1627 5q35.3 human S142-p 452446 NGLARLSsPVLHRLR molecular association, regulation; intracellular localization cytoskeletal reorganization EB3(INDUCES); PXN(INDUCES); ACTB(INDUCES) 23979715; 24637538; 30467237; 35977504 6 87 28 -FUNDC1 FUNDC1 Membrane protein, multi-pass; Mitochondrial Q8IVP5 139341 Xp11.3 human S13-p 2025373 PPPQDYEsDDDSYEV protein stabilization; molecular association, regulation autophagy, inhibited LC3A(DISRUPTS); LC3B(DISRUPTS); HSC70(DISRUPTS) 24746696; 25126723; 27757847; 30591555 8 24 7 -BRAF BRAF EC 2.7.11.1; KINASE; Kinase, protein; Oncoprotein; Protein kinase, Ser/Thr (non-receptor); Protein kinase, TKL P15056 673 7q34 human S465-p 4959522 TVGQRIGsGSFGTVY PK_Tyr_Ser-Thr molecular association, regulation; activity, inhibited BRAF(DISRUPTS) 31929109 3 6 4 -EGFR EGFR EC 2.7.10.1; KINASE; Kinase, protein; Membrane protein, integral; Oncoprotein; Protein kinase, TK; Protein kinase, tyrosine (receptor) P00533 1956 7p11.2 human K716-ub 1065306 ETEFKKIkVLGSGAF PK_Tyr_Ser-Thr receptor internalization, induced; receptor recycling, inhibited; protein degradation 16543144; 17940017 2 5 0 -PRKD2 PRKD2 EC 2.7.11.13; KINASE; Kinase, protein; Motility/polarity/chemotaxis; Protein kinase, CAMK; Protein kinase, Ser/Thr (non-receptor) Q9BZL6 25865 19q13.32 human Y87-p 178601700 KFPECGFyGLYDKIL intracellular localization cell motility, inhibited; cell adhesion, inhibited 28842658 1 0 0 -NR1I2 PXR DNA-binding; Nuclear receptor O75469 8856 3q13.33 human T408-p 9730704 RSINAQHtQRLLRIQ Hormone_recep protein degradation; molecular association, regulation; intracellular localization autophagy, induced; transcription, inhibited; transcription, altered FGR(INDUCES); N-CoR1(DISRUPTS); RXRA(DISRUPTS) 19617467; 26534988 3 0 0 -HADHA HADHA ACETYLTRANSFERASE; Acetyltransferase; Amino Acid Metabolism - lysine degradation; Amino Acid Metabolism - tryptophan; Amino Acid Metabolism - valine, leucine and isoleucine degradation; Carbohydrate Metabolism - butanoate; Carbohydrate Metabolism - propanoate; EC 1.1.1.211; EC 4.2.1.17; Lipid Metabolism - fatty acid; Lipid Metabolism - fatty acid elongation in mitochondria; Lipid Metabolism - unsaturated fatty acid biosynthesis; Lyase; Mitochondrial; Other Amino Acids Metabolism - beta-alanine; Oxidoreductase; Secondary Metabolites Metabolism - limonene and pinene degradation P40939 3030 2p23.3 human K406-ub 27192523 RGQQQVFkGLNDKVK 3HCDH_N protein degradation; ubiquitination 27457618 1 2 0 -SCN5A SCN5A Channel, sodium; Membrane protein, integral; Membrane protein, multi-pass Q14524 6331 3p22.2 human T594-p 25244201 LHGKKNStVDCNGVV Na_trans_cytopl activity, inhibited 22514276 1 0 0 -Slc12a3 NCCT Membrane protein, integral; Membrane protein, multi-pass; Transporter; Transporter, SLC family P55018 54300 19p13-p12 rat T53-p 469616 GSTLYLRtFGYNTID AA_permease_N activity, induced; ubiquitination; intracellular localization; receptor internalization, inhibited 20445498; 22651238; 22966159; 24668812 25 3 0 ubiquitination reduced -RMDN3 FAM82A2 Apoptosis; Membrane protein, integral; Mitochondrial Q96TC7 55177 15q15.1 human Y176-p 19009800 DAESEGGyTTANAES molecular association, regulation; intracellular localization cell growth, induced; signaling pathway regulation CSK(INDUCES); PKACA(INDUCES); RAF1(DISRUPTS); PTP1B(DISRUPTS); 14-3-3 beta(DISRUPTS); RAF1(INDUCES); 14-3-3 beta(INDUCES); DGKA(DISRUPTS) 21513978; 22544307; 24501773; 31075141 4 0 1 MAPK pathway; inhibits MAPK signaling pathway -IRF1 IRF1 Transcription factor; Tumor suppressor P10914 3659 5q31.1 human S219-p 31839600 FQVSPMPsTSEATTD molecular association, regulation; activity, inhibited transcription, inhibited NFkB-p65(DISRUPTS) 24396068 1 0 0 Phosphorylation impairs iNFkB-p65 interaction and PCAF mediated acetylation K310 -suppression of IFN-beta production -SPAG5 SPAG5 Cell cycle regulation Q96R06 10615 17q11.2 human T978-p 1261101 AEMSIMTtELQSLCS intracellular localization 18055457 1 0 0 required for SPAG5 localization to the spindle apparatus during mitosis -GSK3B GSK3B EC 2.7.11.1; EC 2.7.11.26; KINASE; Kinase, protein; Protein kinase, CMGC; Protein kinase, Ser/Thr (non-receptor) P49841 2932 3q13.33 human K183-ub 63354301 GICHRDIkPQNLLLD Pkinase protein degradation 28298444 1 1 0 negatively regulates anti-inflammatory cytokine production -ATXN7 ataxin-7 Nucleolus; Transcription regulation O15265 6314 3p14.1 human K257-sm 10902804 RIMTPSVkVEKIHPK apoptosis, inhibited 19843541 1 1 0 -RAF1 RAF1 EC 2.7.11.1; KINASE; Kinase, protein; Oncoprotein; Protein kinase, Ser/Thr (non-receptor); Protein kinase, TKL P04049 5894 3p25.2 human S494-p 447745 FGLATVKsRWSGSQQ PK_Tyr_Ser-Thr enzymatic activity, induced 11447113; 12551923; 12865432 5 0 0 -CALD1 Caldesmon Actin-binding Q05682 800 7q33 human S744-p 456707 GLKVGVSsRINEWLT Caldesmon cell motility, altered; cytoskeletal reorganization 16800003; 20128924 5 1 0 -Cttn Cortactin Actin-binding; Cytoskeletal; Motility/polarity/chemotaxis Q60598 13043 7|7 F5 mouse K152-ac 1880005100 TEKHASQkDYSSGFG HS1_rep molecular association, regulation; acetylation; intracellular localization DIP2A(INDUCES) 31600191 1 0 0 DIP2A regulates spine morphology and synaptic transmission through acetylation of cortactin; Interaction of DIP2A-cortactin is required for acetylated cortactin; acetylation mimetic cortactin rescues the repetitive behaviors in Dip2a KO mice; acetylation alleviated abnormal PSD95 clustering at the spine head in DIP2A KO neurons -AR AR DNA-binding; Nuclear receptor; Transcription factor P10275 367 Xq12 human Y365-p 478251 AYQSRDYyNFPLALA Androgen_recep transcription, induced; cell growth, altered 17494760 3 2 0 -SUPT16H SPT16 Transcription initiation complex Q9Y5B9 11198 14q11.2 human K674-ac 474904 IRPNIAQkRMQGSLE SPT16 protein stabilization; molecular association, regulation BRD4(INDUCES) 35904816 1 3 50 SPT16H?BRD4 interacts with HDAC1 and EZH2 contributing to gene silencing, IFN signaling via epigenetic suppression -ERBB3 HER3 EC 2.7.10.1; KINASE; Kinase, protein; Membrane protein, integral; Oncoprotein; Protein kinase, TK; Protein kinase, tyrosine (receptor) P21860 2065 12q13.2 human Y1262-p 3971613 TPDEDYEyMNRQRDG molecular association, regulation GRB2(INDUCES); GRB7(INDUCES) 16729043; 9516479 2 1 2 Grb2 binding is reduced campared with Grb7. -NOVA2 NOVA2 Q9UNW9 4858 19q13.32 human T27-p 1869341902 VCTKRSNtGEEGEYF intracellular localization 32492405 1 1 0 Phosphorylated NOVA2 translocates to cytosol leading to reduced E29 inclusion in BK channel and thereby inhibiting BK channel activity. -Glp1r GLP1R GPCR, family 2; Membrane protein, integral; Membrane protein, multi-pass; Receptor, GPCR P32301 25051 20p12 rat S442-p 451371 PLKCPTSsVSSGATV receptor desensitization, altered 8702711 1 0 0 -KAT5 Tip60 ACETYLTRANSFERASE; Acetyltransferase; EC 2.3.1.48; Nuclear receptor co-regulator; Nucleolus Q92993 10524 11q13.1 human Y294-p 29431804 HPPGNEIyRKGTISF MOZ_SAS molecular association, regulation; acetylation; intracellular localization; enzymatic activity, inhibited cell cycle regulation; apoptosis, induced Fe65(INDUCES) 24044023 1 0 0 -USF1 USF1 DNA-binding; Transcription factor P22415 7391 1q23.3 human K199-ac 7652100 PRTTRDEkRRAQHNE molecular association, regulation transcription, inhibited DNA(INDUCES) 19389701 1 0 0 -HNRNPU hnRNP U DNA-binding; Nuclear receptor co-regulator; RNA splicing; RNA-binding; Spliceosome Q00839 3192 1q44 human S59-p 468001 AMEPGNGsLDLGGDS molecular association, regulation; intracellular localization cell cycle regulation; DNA repair, induced NEIL1(DISRUPTS); Ku70(INDUCES) 25986610; 27303920 4 62 7 transient dissociation of NEIL1 from chromatin; localizes to centrosomes, the midzone and the midbody in mitosis -PCNA PCNA Cell cycle regulation; DNA replication P12004 5111 20p12.3 human Y250-p 231166701 DMGHLKYyLAPKIED PCNA_C ubiquitination cell cycle regulation 28924044 1 1 0 -Cdkn2c CDKN2C Cell cycle regulation; Inhibitor; Protein kinase, regulatory subunit Q60772 12580 4 C7|4 51.32 cM mouse K112-ub 6423505 LPLHLAAkEGHLPVV Ank_2 protein degradation 19029828 1 0 0 -ABI1 Abi-1 Adaptor/scaffold; Motility/polarity/chemotaxis Q8IZP0 10006 10p12.1 human S410-p 12626407 DIPMFDDsPPPPPPP molecular association, regulation cell motility, altered; cytoskeletal reorganization 21419341 1 1 0 regulates WRC (WAVE2 regulatory complex) interaction with Arp2/3 and lamellipodial protrusion -Smad3 SMAD3 DNA-binding; Nuclear receptor co-regulator; Transcription factor Q8BUN5 17127 9|9 C mouse S309-p 1243501 EVFAECLsDSAIFVQ MH2 activity, induced; intracellular localization 17991884 2 1 0 Nuclear translocation -Ikbkg IKKG Adaptor/scaffold; Protein kinase, regulatory subunit O88522 16151 X|X A7.3 mouse K270-sm 2255104 AEEALVAkQELIDKL CC2-LZ molecular association, regulation; intracellular localization; phosphorylation transcription, induced; signaling pathway regulation CYLD(DISRUPTS) 23825957; 26596471 6 0 0 induces p65 phosphorylation, induces IKK/NF-KB signaling; induces phosphorylation of IKB-alpha, NF-kB p65, nuclear translocation of p65, thus inducing NF-kB signaling -PLAU uPA EC 3.4.21.73; Motility/polarity/chemotaxis; Protease; Secreted; Secreted, signal peptide P00749 5328 10q22.2 human S158-p 451052 CADGKKPsSPPEELK molecular association, regulation; intracellular localization; activity, inhibited cell motility, altered; cell adhesion, altered; cytoskeletal reorganization ITGA5(INDUCES); ITGB5(INDUCES) 18844213; 9151681; 9765311 3 0 0 S158 phosphorylation confers to prourokinase the antagonistic properties; reduces ITGB5/ITGA5 activation and its interaction with vitronectin and talin; ligand-dependent uPA redistribution severely impaired in a S158/323E mutant -F2R PAR1 Cell development/differentiation; GPCR, family 1; Membrane protein, integral; Membrane protein, multi-pass; Receptor, GPCR P25116 2149 5q13.3 human S392-p 3627503 ILCCKESsDPSSYNS receptor desensitization, altered 10413505 1 0 0 receptor shutoff (not internalization) -RAF1 RAF1 EC 2.7.11.1; KINASE; Kinase, protein; Oncoprotein; Protein kinase, Ser/Thr (non-receptor); Protein kinase, TKL P05625 396245 chicken Y340-p 447749 RGQRDSSyYWEIEAS enzymatic activity, induced apoptosis, inhibited 12843393; 12952943 29 1 1 -Mapk1 ERK2 EC 2.7.11.24; KINASE; Kinase, protein; Protein kinase, CMGC; Protein kinase, Ser/Thr (non-receptor) P63086 116590 11q23 rat T179-p 3189583 ADPDHDHtGFLTEYV Pkinase enzymatic activity, induced translation, altered 15757502 4 12 40 phenylphrine induces protein synthesis -Prkra PACT Activator; RNA processing; RNA-binding Q9WTX2 23992 2|2 C3 mouse S18-p 453415 PPLQREDsGTFSLGK molecular association, regulation; phosphorylation translation, altered; cell growth, inhibited; apoptosis, induced PKR(INDUCES) 15299031; 16574643; 16861340 3 63 135 -Sarm1 SARM1 D3ZUM2 287545 rat S548-p 4739912 AAREMLHsPLPCTGG intracellular localization 32968873 3 9 3 stimulates protein oligomerization; regulation of axonal degenearion and mitochondrial transport -CDC73 CDC73 Cell cycle regulation; Tumor suppressor Q6P1J9 79577 1q31.2 human K243-ub 603484760 TILQSTGkNFSKNIF CDC73_N protein degradation; ubiquitination 35551175 1 2 0 -ENOX2 ENOX2 Cell surface; Cytoskeletal; EC 1.-.-.-; Oxidoreductase Q16206 10495 Xq26.1 human S504-p 25602101 ENLKEKEsCASRLCA protein stabilization cell motility, induced; cell growth, induced 22659163 1 0 0 -Tgif1 TGIF DNA-binding; Nuclear receptor co-regulator; Transcription, coactivator/corepressor P70284 21815 17|17 E1.3 mouse T239-p 1868546603 LFNTPPPtPPDLNQD molecular association, regulation carcinogenesis, induced; cell growth, induced; transcription, induced; signaling pathway regulation TWIST1(INDUCES); TWIST1(DISRUPTS) 31152009; 31268604 2 0 0 TGIF T239D/T235D mutant does not inhibit TWIST1 expression; in Kras active mutant cells; TGIF T239D/T235D mutant stimulates proliferation of Capan-2 cells -ABCF1 ABCF1 RNA-binding; Translation Q8NE71 23 6p21.33 human S140-p 454452 AALIQDQsEEEEEEE molecular association, regulation 17894550 1 62 8 S109 aqnd S140 phosphorylation may affect ABCF1-eIF2 binding to 60S 80S subunits and small polysomes. -AHSG FETUA Secreted; Secreted, signal peptide P02765 197 3q27.3 human S330-p 467425 VVSLGSPsGEVSHPR activity, inhibited 31084489 3 23 13 Inhibits insulin-induced GLUT4 translocation, glucose uptake/glycogen synthesis -PTK2 FAK EC 2.7.10.2; KINASE; Kinase, protein; Protein kinase, TK; Protein kinase, tyrosine (non-receptor) Q05397 5747 8q24.3 human S910-p 447964 KLQPQEIsPPPTANL molecular association, regulation carcinogenesis, induced; cytoskeletal reorganization; cell adhesion, altered; cell adhesion, inhibited; cell growth, altered ITGB3(INDUCES); P130Cas(DISRUPTS); talin 1(DISRUPTS) 17692050; 20519501; 33999101 20 48 0 regulates FA turnover, ECM degradation, and metastasis -INVS INVS Q9Y283 27130 9q31.1 human T866-p 55578723 ARRLETStLSEDFQV cytoskeletal reorganization 27220846 1 0 0 Akt2 plays a more prominent role in ciliary development than Akt1, tubular differentiation -Syn1 SYN1 Vesicle O88935 20964 X A1.3|X 16.37 cM mouse S553-p 448377 ARPPASPsPQRQAGA cytoskeletal reorganization; signaling pathway regulation 25463523; 30016727 8 22 10 protects against ischemic injury and cell death; OGD induces morphological damage of neurites in cortical neurons; multiple signaling pathways converge onto SynI and regulated by phosphorylation, hippocampal-dependent learning de?cits -DMD dystrophin Cytoskeletal; Motility/polarity/chemotaxis P11532 1756 Xp21.2-p21.1 human S3066-p 35542205 GPWERAIsPNKVPYY WW protein stabilization; molecular association, regulation cytoskeletal reorganization DAG1(INDUCES) 25082828 2 1 0 -Myrf MRF DNA-binding; Membrane protein, integral Q3UR85 225908 19|19 A mouse S259-p 20804942 PSKKRKHsESPPNTL molecular association, regulation transcription, inhibited Huntingtin(INDUCES) 32270922 1 2 0 induces demyelination -aurka AurA EC 2.7.11.1; KINASE; Kinase, protein; Oncoprotein; Protein kinase, Other; Protein kinase, Ser/Thr (non-receptor) Q91820 397925 frog T295-p 448784 APSSRRTtLCGTLDY Pkinase enzymatic activity, induced 12422018 66 12 7 -G6PD G6PD Carbohydrate Metabolism - pentose phosphate pathway; Cell development/differentiation; EC 1.1.1.49; Other Amino Acids Metabolism - glutathione; Oxidoreductase P11413 2539 Xq28 human K403-ac 11320991 PNEAVYTkMMTKKPG G6PD_C protein degradation; molecular association, regulation; enzymatic activity, inhibited; protein conformation; enzymatic activity, altered carcinogenesis, inhibited; cell growth, inhibited; apoptosis, induced p53(INDUCES); G6PD(DISRUPTS) 24769394; 27586085; 35065072; 37798264 4 3 3 induction of apoptotic signaling; negatively regulates dimerization; reshaped the dimer interface and propagated to the substrate binding -GMNN Geminin Cell cycle regulation; Motility/polarity/chemotaxis O75496 51053 6p22.3 human K127-ub 573758968 LHKEIEQkDNEIARL Geminin molecular association, regulation CDT1(DISRUPTS) 34599168 1 2 0 inhibits MCM proteins binding to Cdt1; cancer-derived SPOP mutants increase replication origin ?ring, re-replication, and genome instability, increased by ATR inhibition -Grik5 GluR KA2 Channel, ligand-gated; Membrane protein, integral; Membrane protein, multi-pass Q63273 24407 1q21 rat S836-p 31033002 STRRSAEsEEVSVCQ activity, induced 23066089 1 0 0 GluR KA2 mediated potentiation of heteromeric KARs -Plk1 PLK1 EC 2.7.11.21; KINASE; Kinase, protein; Protein kinase, Other; Protein kinase, Ser/Thr (non-receptor) Q07832 18817 7 F2|7 65.52 cM mouse Y445-p 54066601 DSTRLILyNDGDSLQ POLO_box enzymatic activity, induced cell cycle regulation 26755576 3 1 0 -NPM/ALK NPM-ALK KINASE; Kinase, protein; Protein kinase, TK; Protein kinase, tyrosine (receptor) AAA58698 human S497-p 27275105 AKREEERsPAAPPPL phosphorylation carcinogenesis, altered; cell growth, altered 21045017 1 1 0 -Prkn PARK2 EC 6.3.2.-; EC 6.3.2.19; Ligase; Translation; Translation regulation; UBIQUITIN LIGASE; Ubiquitin conjugating system; Ubiquitin ligase Q9WVS6 50873 17 A1|17 7.8 cM mouse S9-p 11096954 IVFVRFNsSYGFPVE ubiquitin molecular association, regulation; ubiquitination; intracellular localization; phosphorylation carcinogenesis, inhibited; signaling pathway regulation RIPK3(INDUCES) 31358971 3 1 1 binds to RIPK3 disrupting RIPK3-RIPK1 binding, induces RIPK3 ubiquitination, inhibits RIPK3 and MLKL phosphorylation, regulates RIPK3 localization, induces Parkin-RIPK3 pathway -ANXA2 ANXA2 Calcium-binding; Lipid-binding; Motility/polarity/chemotaxis P04272 282689 cow Y24-p 449483 HSTPPSAyGSVKAYT intracellular localization exocytosis, induced; cytoskeletal reorganization 32917016 29 64 2613 -Gabbr1 GABBR1 GPCR, family 3; Membrane protein, integral; Membrane protein, multi-pass; Receptor, GPCR Q9Z0U4 81657 20p12 rat K923-ub 7251351 EKSRLLEkENRELEK receptor recycling, inhibited; protein degradation; intracellular localization 27573246 2 1 2 -H3C14 HIST2H3A/C/D DNA-binding Q71DI3 126961 1q21.2 human K79-m2 18465106 REIAQDFkTDLRFQS Histone molecular association, regulation L3MBTL iso4(INDUCES) 23583077 0 3 2 -BAIAP2L1 IRTKS Adaptor/scaffold; Cytoskeletal Q9UHR4 55971 7q21.3-q22.1 human S331-p 2509171 PSLQRSVsVATGLNM molecular association, regulation p53(DISRUPTS) 28647685 1 28 12 -Slc1a2 GLT1 Membrane protein, integral; Membrane protein, multi-pass; Transporter; Transporter, SLC family P43006 20511 2 E2|2 54.13 cM mouse S562-p 486052 NGKSADCsVEEEPWK intracellular localization; activity, inhibited 34516830 1 6 0 -SRF SRF Motility/polarity/chemotaxis; Transcription factor P11831 6722 6p21.1 human S85-p 451801 GSEGDSEsGEEEELG molecular association, regulation DNA(INDUCES) 1547771 3 5 0 -Kirrel2 KIRREL2 Cell adhesion; Membrane protein, integral Q7TSU7 243911 7|7 B1 mouse Y596-p 50247600 KDPTNGYyRVRGVSV protein processing; intracellular localization 26324709 1 1 0 -HIF1A HIF1A Autophagy; DNA-binding; Transcription factor Q16665 3091 14q23.2 human T63-p 56589703 KASVMRLtISYLRVR protein stabilization transcription, induced 27245613; 27245614 2 2 0 -Hsf1 HSF1 DNA-binding; Transcription factor P38532 15499 15 D3|15 35.95 cM mouse S307-p 449046 EPPSPPHsPRVLEAS Vert_HS_TF activity, inhibited transcription, inhibited; transcription, altered 11162511; 28724629; 33846884 26 56 3 -Dnm1 DYN1 EC 3.6.5.5; Hydrolase; Microtubule-binding; Motility/polarity/chemotaxis; Motor; Vesicle P39053 13429 2 B|2 22.09 cM mouse S774-p 450205 SVPAGRRsPTSSPTP molecular association, regulation endocytosis, inhibited ITSN1(DISRUPTS) 29199069 14 34 21 peptide interferes with VGLUT1 binding to ITSN1; diurnal variations in the phosphorylation -KCNJ1 ROMK Channel, potassium; Membrane protein, integral; Membrane protein, multi-pass P48048 3758 11q24.3 human T193-p 2813503 KKRAKTItFSKNAVI IRK_C molecular association, regulation; activity, inhibited ROMK(DISRUPTS) 22139477 2 0 0 regulates pH sensitivity of the channel -YES1 Yes EC 2.7.10.2; KINASE; Kinase, protein; Oncoprotein; Protein kinase, TK; Protein kinase, tyrosine (non-receptor) P07947 7525 18p11.32 human Y537-p 447620 FTATEPQyQPGENL_ enzymatic activity, inhibited carcinogenesis, inhibited; cell growth, inhibited; apoptosis, induced 12640114; 35041461 5 23 1248 -KMT2D MLL4 iso3 EC 2.1.1.43; METHYLTRANSFERASE; Methyltransferase; Methyltransferase, protein lysine; Nuclear receptor co-regulator; Transcription regulation O14686-3 8085 12q13.12 human S1331-p 1217705 RGRARLKsTASSIET molecular association, regulation; methylation; activity, inhibited transcription, inhibited; signaling pathway regulation DNA(DISRUPTS) 30943409 1 1 5 regulates H3 K4 me1/2 -Tlr2 TLR2 Apoptosis; Cell surface; Membrane protein, integral; Motility/polarity/chemotaxis; Receptor, misc. Q9QUN7 24088 3|3 E3 mouse Y647-p 1876860404 CYDAFVSySEQDSHW TIR activity, induced; protein stabilization; molecular association, regulation; ubiquitination transcription, induced SH3BP2(INDUCES); PPP1R11(DISRUPTS); MYD88(INDUCES) 35362478 1 0 0 inhibits ubiquitination -RELA NFkB-p65 DNA-binding; Nuclear receptor co-regulator; Transcription factor Q04206 5970 11q13.1 human S529-p 447799 GLPNGLLsGDEDFSS activity, induced; intracellular localization cell cycle regulation; carcinogenesis, induced; cell growth, induced; apoptosis, inhibited; transcription, induced; transcription, altered 11259436; 12444159; 14963024; 26082493; 33676898; 36035991 27 3 1 -MAP4 MAP4 Cytoskeletal; Motility/polarity/chemotaxis P27816 4134 3p21.31 human S696-p 449564 PNKELPPsPEKKTKP cytoskeletal reorganization 25746230 3 44 1 promotes microtubule depolymerization, induces vascular permeability and dysfunction of endothelial barrier. -PAPOLA PAP-alpha EC 2.7.7.19; RNA processing; RNA splicing; Transferase P51003 10914 14q32.2 human K445-sm 2586345 VIGLVFKkTENSENL protein stabilization; enzymatic activity, inhibited 18281463 1 0 0 -Mtss1 MTSS1 Adaptor/scaffold; Motility/polarity/chemotaxis; Tumor suppressor Q8R1S4 211401 15|15 D1 mouse Y397-p 463827 HLPDYAHyYTIGPGM cytoskeletal reorganization 17224454 1 1 6 -Tet2 TET2 EC 1.14.11.n2; Oxidoreductase; Tumor suppressor Q4JK59 214133 3|3 G3 mouse S97-p 3202572 GGIKRTVsEPSLSGL protein stabilization; molecular association, regulation; ubiquitination cell differentiation, induced; transcription, induced 14-3-3 beta(INDUCES) 31164154 3 17 5 inhibits ubiquitination, induces transcription of differentiation related genes -Dab1 DAB1 iso2 Adaptor/scaffold Q6XBN7 chicken S475-p 479422 TPAPRQSsPSKSSAS protein degradation; ubiquitination 21111810 7 0 0 -FGF1 FGF1 Cell development/differentiation; Cytokine; Motility/polarity/chemotaxis P05230 2246 5q31.3 human S131-p 31954800 VGLKKNGsCKRGPRT FGF intracellular localization apoptosis, altered; apoptosis, induced; signaling pathway regulation 24595027; 26844696; 27773526; 29048426 4 0 0 inhibits p53-dependent anti-apoptotic activity; nuclear export; Inhibits FGF1 anti-apoptotic activity.; S131R mutation shows reduction in mitogenic stimulation, increase in ?broblast growth factor receptor-1c activation, and prolonged duration of glucose lowering in ob/ob hyperglycemic mice. -STRAP STRAP Adaptor/scaffold; RNA splicing; UBIQUITIN LIGASE; Ubiquitin ligase Q9Y3F4 11171 12p12.3 human T175-p 11267002 LWDHATMtEVKSLNF phosphorylation apoptosis, altered 19880523 2 1 0 negatively regulates ASK1 phosphorylation and ASK1-mediated signaling -Cacng2 Stargazin Channel, calcium; Membrane protein, integral; Membrane protein, multi-pass O88602 12300 15 E1|15 36.92 cM mouse S241-p 455317 QRRSRSSsRSTEPSH activity, induced; intracellular localization 15664178; 20670832 3 0 0 AMPAR immobilization in synaptic membrane; enhances AMPA receptor responses and is required for long-term potentiation -USP21 USP21 DEUBIQUITINASE; EC 3.4.19.12; Protease; Ubiquitin conjugating system; Ubiquitin-specific protease Q9UK80 27005 1q23.3 human S538-p 63253102 VYNDSRVsPVSENQV UCH molecular association, regulation STING(INDUCES) 28254948 1 1 0 -GLI3 GLI3 C2H2-type zinc finger protein; Transcription factor P10071 2737 7p14.1 human K784-ub 6097709 HVKLERLkQVNGMFP protein processing 16705181 1 0 0 -RPL23A RPL23A Ribosomal; Translation P62750 6147 17q11.2 human K89-ub 1884021301 TTESAMKkIEDNNTL protein degradation; ubiquitination transcription, altered 35637966 1 1 0 HERC3 could control protein expression and ubiquitination of c-Myc/p21 via RPL23A -H4C1 H4 DNA-binding P62805 8359 6p22.2 human R17-m1 1873284318 LGKGGAKrHRKVLRD CENP-T_C methylation 28874563 1 0 0 increases R3 monomethylation by PRMT1 and PRMT5 -Kif17 KIF17 Microtubule-binding; Motor Q99PW8 16559 4|4 D3 mouse S1029-p 1720900 SKAKRKKsKNSFGGE molecular association, regulation; intracellular localization; activity, inhibited endocytosis, induced APBA1(DISRUPTS) 18066053; 24931613; 30458707 3 0 0 Phosphorylation disrupts KIF17 interaction with its cognate cargo. and reduces post-ER trafficking in neurons.; Promotes cell-autonomous disc shedding and phagocytosis of outer segments -CDC25A CDC25A EC 3.1.3.48; Motility/polarity/chemotaxis; PHOSPHATASE; Protein phosphatase, dual-specificity P30304 993 3p21.31 human S321-p 472278 QSLSLASsPKGTIEN M-inducer_phosp protein degradation; ubiquitination cell cycle regulation; apoptosis, inhibited 34363019 2 3 0 -HTT Huntingtin Cytoskeletal P42858 3064 4p16.3 human S534-p 465626 EDILSHSsSQVSAVP protein stabilization 16782707 0 1 0 reduces cellular toxicity -Esyt1 ESYT1 Membrane protein, integral; Membrane protein, multi-pass Q3U7R1 23943 10|10 D3 mouse S314-p 15409842 QDVAQLRsPLPRGII molecular association, regulation GLUT4(INDUCES) 19255425 1 1 3 activates insulin-dependent glucose uptake -Gab1 GAB1 Adaptor/scaffold; Motility/polarity/chemotaxis Q9QYY0 14388 8|8 C2 mouse Y628-p 447948 KGDKQVEyLDLDLDS molecular association, regulation; enzymatic activity, induced cell motility, induced; apoptosis, inhibited; signaling pathway regulation SHP-2(INDUCES) 28365441; 33786575 24 25 438 FoxO1-GAB1-pAKT signaling -CSF2RB CSF2RB Membrane protein, integral; Receptor, cytokine P32927 1439 22q12.3 human Y766-p 450104 VKSGFEGyVELPPIE activity, induced; molecular association, regulation apoptosis, altered; signaling pathway regulation; transcription, altered; cell growth, altered LYN(INDUCES); GRB2(INDUCES); SHC1(INDUCES) 10329850; 10672044; 10704825; 22177802; 8752899; 9257712 6 1 9 induces JAK/STAT signaling; Phosphorylation of Y628, Y711, or Y766 is necessary and sufficient for STAT activation by IL-5. -Eif2b5 eIF2B-epsilon Translation; Translation initiation Q64350 192234 11q23 rat S712-p 449907 LREAEEEsSDDD___ W2 molecular association, regulation eIF2-alpha(INDUCES) 11500362 3 10 2 -PA2G4 Ebp1 Nuclear receptor co-regulator; Nucleolus; Transcription, coactivator/corepressor Q9UQ80 5036 12q13.2 human K93-sm 11539305 VCHFSPLkSDQDYIL Peptidase_M24 sumoylation; protein stabilization; intracellular localization carcinogenesis, inhibited; cell growth, inhibited; transcription, inhibited 19946338 1 0 0 mutation of either site abolishes sumoylation at other site -MRE11 MRE11A Cell cycle regulation; DNA repair, damage; DNA-binding; Deoxyribonuclease P49959 4361 11q21 human R592-m2 62978408 ASRGGSQrGRADTGL DNA repair, altered 15741314 0 1 0 -Fndc5 FNDC5 Membrane protein, integral Q8K4Z2 384061 4|4 D2.2 mouse K131-ac 5895766 EAEKMASkNKDEVTM ubiquitination 33754067 1 0 1 SIRT2-dependent deacetylation and deubiquitination increases stability -CASP2 CASP2 Apoptosis; EC 3.4.22.55; Protease P42575 835 7q34 human K77-sm 12004434 MRELIQAkVGSFSQN CARD intracellular localization; enzymatic activity, induced 15882978 1 0 0 maturation of procaspase-2 -ANXA1 ANXA1 Calcium-binding; Lipid-binding P04083 301 9q21.13 human S45-p 9730700 PYPTFNPsSDVAALH intracellular localization exocytosis, altered 19625660 1 1 0 S27A or S45A mutations prevented translocation of ANXA1 to the plasma membrane and stimulated ACTH release -SNAI2 Snail2 Apoptosis; C2H2-type zinc finger protein; Motility/polarity/chemotaxis; Transcription factor O43623 6591 8q11.21 human S96-p 25603908 PPPSDTSsKDHSGSE protein degradation; intracellular localization cell motility, inhibited; transcription, induced CHIP(INDUCES) 22727060; 23851495 2 1 0 WT localizes in cytosol and nucleus; transcriptional activity of E-cadherin; Snail2 luciferase construct, may affect lung metastasis in NSCLC.; WT localized in nucleus and cytoplasm, mutants localize in nucleus; mutants enhance epithelial-mesenchymal transition (EMT) -Elk4 ELK4 DNA-binding; Transcription, coactivator/corepressor P41158 13714 1|1 E4 mouse S380-p 4317600 IHFWSTLsPFAPLSP cell growth, altered 18356083 2 0 0 pro-B cell expansion -IRS4 IRS4 Adaptor/scaffold O14654 8471 Xq22.3 human Y921-p 456294 EADSSSDyVNMDFTK molecular association, regulation cell cycle regulation; carcinogenesis, induced; cell growth, induced GRB2(INDUCES); PLCG1(INDUCES); EBNA1BP2(INDUCES); PIK3R1(INDUCES) 15316024; 35550247 1 6 14 -CHFR CHFR EC 6.3.2.-; EC 6.3.2.19; Ligase; UBIQUITIN LIGASE; Ubiquitin conjugating system; Ubiquitin ligase Q96EP1 55743 12q24.33 human K393-ub 25090300 TQDMLQPkVRRSFSD protein degradation cell cycle regulation 21768102 1 0 0 auto-ubiquitylation and CHFR degradation regulate the G2/M transition -GCM1 GCM1 DNA-binding; Transcription factor Q9NP62 8521 6p12.1 human S275-p 18788304 LSSSRTYsSGDLLPP protein stabilization; molecular association, regulation; acetylation transcription, induced DUSP23(INDUCES) 20855292; 26503785 2 0 0 -Irs2 IRS2 Adaptor/scaffold; Motility/polarity/chemotaxis P81122 384783 8 A1.1|8 5.35 cM mouse S723-p 3217368 GGGYKASsPAESSPE signaling pathway regulation 23359250; 24614172; 31672472 9 15 4 insulin-dependent signaling pathway -MALT1 MALT1 Adaptor/scaffold; Apoptosis; EC 3.4.22.-; Ligase; Nuclear export; Protease; UBIQUITIN LIGASE; Ubiquitin conjugating system Q9UDY8 10892 18q21.32 human K661-ub 2134704 TGSYLVSkDLPKHCL MALT1_Ig protein degradation; molecular association, regulation IKKA(INDUCES) 17948050 1 1 0 activation of NF-kB pathway and IL-2 induction -RUNX3 AML2 DNA-binding; Transcription factor Q13761 864 1p36.11 human T231-p 471996 HFSSQPQtPIQGTSE protein degradation; molecular association, regulation; ubiquitination; activity, inhibited carcinogenesis, induced PIN1(INDUCES) 22580604 1 5 21 The downstream effects occur in the presence of PIN1 -PPARGC1A PGC-1 alpha Nuclear receptor co-regulator; Transcription, coactivator/corepressor Q9UBK2 10891 4p15.2 human S571-p 2045307 RMRSRSRsFSRHRSC activity, inhibited 19915805 4 0 0 -Tbk1 TBK1 EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, Other; Protein kinase, Ser/Thr (non-receptor) Q9WUN2 56480 10|10 D2 mouse Y179-p 23151249 SLYGTEEyLHPDMYE Pkinase phosphorylation signaling pathway regulation 30514903 3 1 4 Y188/199 of IKK? and Y179 TBK1 phosphorylation induce activation of TLR signaling -Skp2 SKP2 Cell cycle regulation; UBIQUITIN LIGASE; Ubiquitin conjugating system; Ubiquitin ligase Q9Z0Z3 27401 15|15 A1 mouse K71-ac 25673100 SPPRKRVkGKGSDKD protein stabilization; intracellular localization carcinogenesis, induced; cell motility, induced 22770219 2 0 0 Skp2 cytoplasmic localization -CDK7 CDK7 Cell cycle regulation; EC 2.7.11.22; EC 2.7.11.23; KINASE; Kinase, protein; Nuclear receptor co-regulator; Protein kinase, CMGC; Protein kinase, Ser/Thr (non-receptor) P50613 1022 5q13.2 human T170-p 448306 GSPNRAYtHQVVTRW Pkinase protein conformation; enzymatic activity, induced cell cycle regulation; cell growth, induced; cytoskeletal reorganization; transcription, altered 32855301; 35337817; 9832506 5 71 91 -Gata4 GATA4 Motility/polarity/chemotaxis; Transcription factor Q08369 14463 14 D1|14 33.24 cM mouse K320-ac 18380902 GIQTRKRkPKNLNKS cell growth, induced; transcription, induced 20833366 1 0 0 -NEDD4 NEDD4 iso4 EC 6.3.2.-; EC 6.3.2.19; Ligase; Nuclear receptor co-regulator; UBIQUITIN LIGASE; Ubiquitin conjugating system; Ubiquitin ligase P46934-4 4734 15q21.3 human K667-ac 1881518202 FYKMMLHkPITLHDM molecular association, regulation; ubiquitination; intracellular localization matrix protein VP40(INDUCES) 34111220 1 1 0 VP40 VLP production, release of VP40 VLPs, acetylation enhances VP40 ubiquitination, alters VP40 intracellular localization -RAD52 RAD52 DNA repair, damage P43351 5893 12p13.33 human K286-ac 54247385 VSTPSAEkSEAAPPA molecular association, regulation; intracellular localization DNA repair, induced RFA2(INDUCES); RPA3(INDUCES); RAD51(INDUCES); RPA1(INDUCES) 29590107 1 1 0 accumulation of RAD52 at DSB sites -SQSTM1 SQSTM1 Autophagy; Nuclear receptor co-regulator; Ubiquitin conjugating system Q13501 8878 5q35.3 human T350-p 34735619 SKEVDPStGELQSLQ molecular association, regulation; intracellular localization transcription, induced KEAP1(INDUCES) 34774801 1 1 1 regulates NRF2 localization -Kdr VEGFR2 EC 2.7.10.1; KINASE; Kinase, protein; Membrane protein, integral; Protein kinase, TK; Protein kinase, tyrosine (receptor) P35918 16542 5 C3.3|5 40.23 cM mouse S982-p 10940352 FVEEKSLsDVEEEEA PK_Tyr_Ser-Thr receptor internalization, induced; protein degradation 35288568 1 3 0 -TAB1 TAB1 Activator; Motility/polarity/chemotaxis Q15750 10454 22q13.1 human T431-p 456223 ASTLDEAtPTLTNQS activity, inhibited; phosphorylation 15590691; 19393267 5 0 1 inhibits phosphorylation of TAK1; inhibits TAK1 T187 phosphorylation -Tcf7l2 TCF7L2 Apoptosis; Cell cycle regulation; Cell development/differentiation; DNA-binding; Motility/polarity/chemotaxis; Transcription factor Q924A0 21416 19 D2|19 51.59 cM mouse K297-sm 2407415 AIVTPTVkQESSQSD intracellular localization transcription, induced 12727872 1 0 0 -G3BP1 G3BP-1 Adaptor/scaffold; EC 3.6.4.12; EC 3.6.4.13; Helicase; RNA-binding Q13283 10146 5q33.1 human S232-p 449042 EDAQKSSsPAPADIA molecular association, regulation; protein conformation G3BP-1(DISRUPTS) 12642610; 32302572 7 104 29 -MAPKAPK2 MAPKAPK2 EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, CAMK; Protein kinase, Ser/Thr (non-receptor) P49137 9261 1q32.1 human S272-p 448268 SNHGLAIsPGMKTRI Pkinase activity, induced 8846784 1 0 0 -RB1 Rb Nuclear receptor co-regulator; Oncoprotein; Transcription, coactivator/corepressor; Tumor suppressor P06400 5925 13q14.2 human T356-p 447981 DSFETQRtPRKSNLD molecular association, regulation carcinogenesis, induced; cell growth, induced; apoptosis, inhibited E2F1(DISRUPTS) 20223825; 22279936; 26265441 15 19 36 -NUPR1 NUPR1 Apoptosis; Cell cycle regulation; Cell development/differentiation O60356 26471 16p11.2 human K77-ac 465464 LQNSERKkRGARR__ Phospho_p8 intracellular localization 16294328 1 0 0 regulates nuclear transport -Coro1b coronin 1B Actin-binding; Motility/polarity/chemotaxis Q9WUM3 23789 19 A|19 3.85 cM mouse S2-p 456131 ______MsFRKVVRQ intracellular localization exocytosis, altered; cytoskeletal reorganization 21844203 7 0 0 inhibits MC (mast cells) degranulation -Zfpm2 FOG2 C2H2-type zinc finger protein; Nuclear receptor co-regulator Q8CCH7 22762 15 B3.1|15 15.74 cM mouse K915-sm 1873213006 SFERNMIkCEKNGNP molecular association, regulation transcription, induced GATA4(DISRUPTS) 23226341 1 0 0 desumoylation induces repression -PDHA1 PDHA1 Amino Acid Metabolism - valine, leucine and isoleucine biosynthesis; Carbohydrate Metabolism - butanoate; Carbohydrate Metabolism - citrate (TCA) cycle; Carbohydrate Metabolism - glycolysis and gluconeogenesis; Carbohydrate Metabolism - pyruvate; EC 1.2.4.1; Mitochondrial; Oxidoreductase P08559 5160 Xp22.12 human S295-p 468391 RYHGHSMsDPGVSYR E1_dh enzymatic activity, induced carcinogenesis, induced; apoptosis, inhibited 33022274 3 51 241 -IRS1 IRS1 Adaptor/scaffold; Motility/polarity/chemotaxis P35568 3667 2q36.3 human Y896-p 447556 EPKSPGEyVNIEFGS activity, induced; molecular association, regulation; phosphorylation cell cycle regulation GRB2(INDUCES) 11259577; 22081023 13 2 0 regulation of glucose metabolism; Erk1/2 phosphorylation -GLI1 GLI1 C2H2-type zinc finger protein; Oncoprotein; Transcription factor P08151 2735 12q13.3 human S201-p 1034327200 PLEGDMSsPNSTGIQ molecular association, regulation; intracellular localization transcription, inhibited SUFU(INDUCES) DNA(DISRUPTS) 29662197 1 0 0 localized in cytoplasm -Nfil3 E4BP4 DNA-binding; Transcription factor O08750 18030 13 B1|13 27.68 cM mouse S286-p 3197462 EGVVGKSsDGEDEQQ Vert_IL3-reg_TF transcription, inhibited 29311361 1 6 0 NK cell production inhibited -PRKN PARK2 EC 6.3.2.-; EC 6.3.2.19; Ligase; Translation; Translation regulation; UBIQUITIN LIGASE; Ubiquitin conjugating system; Ubiquitin ligase O60260 5071 6q26 human S127-p 1876336800 AVILHTDsRKDSPPA enzymatic activity, inhibited carcinogenesis, induced; cell growth, induced; translation, induced 35191952 1 0 0 inhibits elF4B ubiquitination and degradation -PYHIN1 PYHIN1 Tumor suppressor Q6K0P9 149628 1q23.1 human K138-ac 1881258603 EETLGPQkRKKPSEE intracellular localization 34156286 1 1 0 induces partial cytoplasmic localization -FANCD2 FANCD2 DNA repair, damage Q9BXW9 2177 3p25.3 human T691-p 470035 YGLEEYDtQDGIAIN FancD2 activity, induced cell cycle regulation 16943440 1 2 2 promotes monoubiquitination of FANCD2 -BECN1 beclin 1 Adaptor/scaffold; Autophagy; Membrane protein, peripheral Q14457 8678 17q21.31 human S93-p 5473540 ARMMSTEsANSFTLI molecular association, regulation; phosphorylation carcinogenesis, inhibited; autophagy, induced; apoptosis, induced; signaling pathway regulation DNAJB12(INDUCES); Bcl-2(DISRUPTS); SLC7A11(INDUCES) 23878393; 24685158; 26834238; 30057310; 31220095; 31696776; 32187724; 34820368; 36192481; 36410674 14 2 1 -Marcksl1 MLP Cell cycle regulation P28667 17357 4 D2.2|4 63.26 cM mouse T183-p 454301 PQAAEPStPSGPESG MARCKS protein conformation cytoskeletal reorganization; cell motility, inhibited 22751924 1 16 57 Increases actin stability and regulation of dendritic filopodium generation in neurons -AR AR DNA-binding; Nuclear receptor; Transcription factor P10275 367 Xq12 human S96-p 448416 QQQGEDGsPQAHRRG Androgen_recep activity, induced; protein stabilization; intracellular localization; protein conformation carcinogenesis, induced; cell growth, induced; transcription, induced; transcription, altered 15684382; 28003546; 34435708 9 11 0 inhibits ubiquitination -CSF1R CSFR EC 2.7.10.1; KINASE; Kinase, protein; Membrane protein, integral; Oncoprotein; Protein kinase, TK; Protein kinase, tyrosine (receptor) P07333 1436 5q32 human Y809-p 448365 DIMNDSNyIVKGNAR PK_Tyr_Ser-Thr activity, induced; phosphorylation cell cycle regulation; transcription, altered; cell growth, altered 15217985; 15297464; 7526094; 8761310 21 2 12 Substitution of T38A enhances Ets-1 rescue of CSFR defective receptor (Y809F). -RARG RARG DNA-binding; Nuclear receptor P13631 5916 12q13.13 human S390-p 1869601000 ITDLRGIsTKGAERA Hormone_recep activity, induced 31740618 1 0 0 -STMN1 STMN1 Cytoskeletal P16949 3925 1p36.11 human S63-p 448557 AAEERRKsHEAEVLK Stathmin protein degradation; molecular association, regulation; intracellular localization; activity, inhibited; phosphorylation cell cycle regulation; apoptosis, altered; carcinogenesis, inhibited; cell growth, inhibited; apoptosis, induced; cell motility, induced; cell motility, inhibited; signaling pathway regulation; autophagy, induced; cell growth, induced; cytoskeletal reorganization TUBA1A(DISRUPTS); TUBA4A(DISRUPTS); SQSTM1(INDUCES); TUBB(DISRUPTS) 10913145; 11015208; 11415983; 16554300; 17001604; 19359244; 20110360; 25198505; 30628717; 31546234; 33839152; 7775478; 9271428 26 56 32 -NEDD1 NEDD1 Cell cycle regulation Q8NHV4 121441 12q23.1 human S411-p 3207015 SSLGDMFsPIRDDAV molecular association, regulation; intracellular localization cytoskeletal reorganization HAUS8(INDUCES) 21690413; 22595525 3 19 0 Microtubule amplification pathway regulation -LIFR LIFR Membrane protein, integral; Receptor, cytokine P42702 3977 5p13.1 human K886-ac 62856001 CKALQFQkSVCEGSS protein conformation 28122243 1 1 0 ESC pluripotency in vivo -TBC1D3 TBC1D3 GAP; GAP, Rab; Oncoprotein Q8IZP1 729873 17q12 human K166-ub 64210902 FRDRYGTkQRELLHI RabGAP-TBC protein degradation; ubiquitination 28422741 1 0 0 -Cttn Cortactin Actin-binding; Cytoskeletal; Motility/polarity/chemotaxis Q60598 13043 7|7 F5 mouse T24-p 471533 GGADDWEtDPDFVND molecular association, regulation carcinogenesis, induced ARPC2(DISRUPTS) 30610108 1 5 6 increased invadopodia activity -Shc1 SHC1 iso2 Adaptor/scaffold; Apoptosis; Mitochondrial; Motility/polarity/chemotaxis P98083-2 20416 3 F1|3 39.11 cM mouse Y239-p 448509 EEPPDHQyYNDFPGK molecular association, regulation; phosphorylation cell motility, induced; cell motility, altered GRB2(INDUCES) 18273058; 23277357 32 22 947 angiogenesis; required for ErbB2- and TGFB mediated tumor metastasis to the lungs.; metastatic spread of tumors; required for migration and invasion of ERB2-expressing cells -FANCA FANCA DNA repair, damage O15360 2175 16q24.3 human K921-sm 40439802 RTFREVLkEEDVHLT protein degradation 25751062 1 0 0 -Esr2 ER-beta DNA-binding; Nuclear receptor O08537 13983 12 C3|12 33.52 cM mouse S87-p 447915 WPTSGHLsPLATHCQ ERbeta_N protein degradation; molecular association, regulation; ubiquitination; intracellular localization transcription, inhibited UBE3A(INDUCES); SRC-1(INDUCES) 10230404; 17962381 3 0 0 -ELF4 ELF4 DNA-binding; Oncoprotein; Transcription factor Q99607 2000 Xq26.1 human S648-p 463814 SPTPAPFsPFNPTSL protein degradation 16581786; 25081543 2 6 1 -PGR PR iso2 DNA-binding; Nuclear receptor; Transcription factor P06401-2 5241 11q22.1 human S390-p 11273301 PDSEASQsPQYSFES Prog_receptor protein degradation; ubiquitination carcinogenesis, altered; cell growth, inhibited; apoptosis, induced 23880761 2 1 0 -PLK1 PLK1 EC 2.7.11.21; KINASE; Kinase, protein; Protein kinase, Other; Protein kinase, Ser/Thr (non-receptor) P53350 5347 16p12.2 human S49-p 2715404 EVLVDPRsRRRYVRG enzymatic activity, induced cell cycle regulation 18427546 1 0 0 -Itpr1 IP3R1 Channel, calcium; Channel, ligand-gated; Membrane protein, integral; Membrane protein, multi-pass P29994 25262 4q41 rat S1589-p 450681 RNAARRDsVLAASRD activity, induced; receptor inactivation, altered 12167631; 15308649 10 51 3 Mutation of site to Glu enhanced, while mutation to Ala inhibited, calcium release through IP3R1.; increases the open probability of the IP3R receptor Ca(2+) channel -UIMC1 RAP80 Nuclear receptor co-regulator; Transcription, coactivator/corepressor Q96RL1 51720 5q35.2 human S44-p 470700 EDAFIVIsDSDGEEP molecular association, regulation SUMO2(INDUCES) 26719330 1 29 3 -Sh2d3c SHEP1 Adaptor/scaffold Q9QZS8 27387 2|2 B mouse Y787-p 452180 VAHHGGLyHTNAEVK molecular association, regulation cytoskeletal reorganization P130Cas(DISRUPTS) 15272013 1 1 1 Y787 phosphorylation inhibits cell migration and membrane ruffling -JAK2 JAK2 EC 2.7.10.2; KINASE; Kinase, protein; Oncoprotein; Protein kinase, TK; Protein kinase, tyrosine (non-receptor) O60674 3717 9p24.1 human K914-sm 31899107 HDNIVKYkGVCYSAG PK_Tyr_Ser-Thr molecular association, regulation; intracellular localization GH receptor(DISRUPTS) 23581279 1 0 0 translocation into the nucleus -H3c1 H3 DNA-binding P68433 360198 13|13 A3.1 mouse K122-ac 3652700 KRVTIMPkDIQLARR Histone transcription, induced 28077651 4 7 3 -Kcnb1 Kv2.1 Channel, cation; Channel, ligand-gated; Channel, potassium; Membrane protein, integral; Membrane protein, multi-pass P15387 25736 3q42 rat S799-p 473567 EKNHFESsPLPTSPK activity, induced; intracellular localization apoptosis, induced 23223293 5 3 0 -MAP9 MAP9 Cell cycle regulation Q49MG5 79884 4q32.1 human S625-p 999603 RKQKKRHsFLESEAL cytoskeletal reorganization 17925329 2 3 2 correct spindle formation during mitosis -PPDPF PPDPF Unknown function Q9H3Y8 79144 20q13.33 human Y17-p 1883583900 LVATHDYyRRRLGST protein stabilization; molecular association, regulation carcinogenesis, induced; cell growth, induced CK1A(INDUCES) 37477088 1 0 0 -H3c1 H3 DNA-binding P68433 360198 13|13 A3.1 mouse K9-m3 1458613 RTKQTARkSTGGKAP Histone molecular association, regulation; methylation; intracellular localization; enzymatic activity, induced cell differentiation, inhibited; cell cycle regulation; carcinogenesis, induced; endocytosis, altered; transcription, induced; transcription, altered; chromatin organization, altered; cell adhesion, altered; transcription, inhibited CBX4(DISRUPTS); HP1 alpha(INDUCES); CBX7(DISRUPTS); CBX3(INDUCES); CBX8(DISRUPTS); CBX1(INDUCES) DNA(INDUCES) 16222246; 17823087; 17967893; 18039862; 18728284; 20062804; 20543957; 20698834; 20935159; 21245376; 23293284; 24430871; 26051938; 26304540; 28666125; 33195484; 33971063 137 24 1 K885A mutant of SETDB1 inhibits enzyme activity but not its localization to target genes, mutant represses some adipogenic genes and inhibits adipocyte differentiation as does WT, but others arenot repressed and don't may not require its enzymatic activity and other H3K9 methyltransferases may be able to compensate. ; axon guidance -NR4A1 Nur77 Apoptosis; DNA-binding; Nuclear receptor P22736 3164 12q13.13 human T61-p 41583607 STFMDGYtGEFDTFL cell motility, induced; cell growth, induced; cytoskeletal reorganization 26155943 1 0 0 required for increase in cell growth, cell motility, monolayer permeability, and formation of actin stress fibers. -KCNK12 KCNK12 Membrane protein, integral; Membrane protein, multi-pass Q9HB15 56660 2p16.3 human S13-p 29668008 PRPPPRRsRRRLPRP activity, induced; intracellular localization 24163367 1 0 0 Channel current is increased in S13D mutant. Phosphorylation affects retrieval/retention signal, and allows KCNK12 to exit the ER and reach the plasma membrane. -NEDD1 NEDD1 Cell cycle regulation Q8NHV4 121441 12q23.1 human T560-p 25533013 PKIASSVtAGVASSL cytoskeletal reorganization 22595525 1 1 0 Negative effect on NEDD1 function -SMC1A Smc1 DNA replication; RNA splicing Q14683 8243 Xp11.22 human S957-p 448697 ISQEEGSsQGEDSVS SMC_N molecular association, regulation; intracellular localization cell cycle regulation; cytoskeletal reorganization RAE1(INDUCES) 11877376; 11877377; 18832153; 21757780 19 20 68 -SATB2 SATB2 DNA-binding Q9UPW6 23314 2q33.1 human K350-sm 2894438 PPIPRAVkPEPTNSS molecular association, regulation; intracellular localization transcription, inhibited DNA(DISRUPTS) 14701874 1 1 0 -NCOA3 SRC-3 ACETYLTRANSFERASE; Acetyltransferase; EC 2.3.1.48; Motility/polarity/chemotaxis; Nuclear receptor co-regulator; Transcription, coactivator/corepressor Q9Y6Q9 8202 20q13.12 human S860-p 454106 NRAVSLDsPVSVGSS protein degradation; molecular association, regulation; ubiquitination carcinogenesis, induced; cell growth, induced; cell growth, inhibited; transcription, induced ER-alpha(DISRUPTS); CUL3(INDUCES) DNA(DISRUPTS) 15383283; 16760465; 22147914; 33542078 7 16 0 -Gch1 GCH1 Cofactor and Vitamin Metabolism - folate biosynthesis; EC 3.5.4.16; Hydrolase P22288 29244 15p14 rat T85-p 10428812 QRQGLLKtPWRAATA GTP_cyclohydroI enzymatic activity, induced 19762783 1 0 0 -NF2 Merlin Cytoskeletal; Motility/polarity/chemotaxis; Tumor suppressor P35240 4771 22q12.2 human K439-ub 964526678 EAEVLALkMAEESER ERM_helical molecular association, regulation; intracellular localization LATS1(DISRUPTS) 30918126 1 2 0 K63 kinked -VRK3 VRK3 EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, CK1; Protein kinase, Ser/Thr (non-receptor) Q8IV63 51231 19q13.33 human S108-p 4762306 RPPTPKSsPQKTRKS molecular association, regulation; intracellular localization; enzymatic activity, induced apoptosis, inhibited ERK2(INDUCES) 27346674 1 11 2 recruitment of phospho-ERK to VHR, VHR phosphatase activity increased, increased Bak and Bax expression, -GPR35 GPR35 GPCR, family 1; Membrane protein, integral; Membrane protein, multi-pass; Receptor, GPCR Q9HC97 2859 2q37.3 human S303-p 1876282806 KAHKSQDsLCVTLA_ receptor internalization, induced; molecular association, regulation; intracellular localization ARR3(INDUCES) 35101446 1 1 0 -SLC6A2 SLC6A2 Membrane protein, integral; Membrane protein, multi-pass; Transporter; Transporter, SLC family P23975 6530 16q12.2 human S259-p 465614 LWKGVKTsGKVVWIT SNF receptor internalization, induced; intracellular localization; activity, inhibited 16740633; 23979140 2 0 0 Raft-rich membrane domains serve as transit cargos for transporter internalization.; effect observed in T258, S259 double mutant -Sv2a SV2A Membrane protein, integral; Membrane protein, multi-pass; Vesicle Q9JIS5 64051 3|3 F2.1 mouse S81-p 4779758 EEEGGASsDATEGHD molecular association, regulation SYT1(INDUCES) 25673844 1 9 11 SV2A retrieval during SV endocytosis, Thr84 of SV2A is critical in promoting the interaction with synaptotagmin-1 -SLC12A1 NKCC2 Membrane protein, integral; Membrane protein, multi-pass; Transporter; Transporter, SLC family P55015 100328575 rabbit T104-p 458228 LQTFGHNtMDAVPKI AA_permease_N activity, induced 16077079 14 2 0 -Plekhg5 PLEKHG5 Q66T02 269608 4|4 E2 mouse S938-p 7104662 PRLLKSKsEASLLQL molecular association, regulation; intracellular localization; enzymatic activity, inhibited cytoskeletal reorganization; cell adhesion, inhibited 14-3-3 beta(INDUCES); RHOA(DISRUPTS); 14-3-3 epsilon(INDUCES); 14-3-3 gamma(INDUCES) 23335514 1 10 0 inhibits targeting to cell border -HIF1A HIF1A Autophagy; DNA-binding; Transcription factor Q16665 3091 14q23.2 human S687-p 31876388 TEKSHPRsPNVLSVA protein stabilization 27027353 1 5 0 -Smad4 SMAD4 DNA-binding; Nuclear receptor co-regulator; Transcription, coactivator/corepressor P97471 17128 18 E2|18 49.51 cM mouse K113-sm 2793926 KNELKHVkYCQYAFD MH1 neural plasticity; transcription, induced 29183317 5 1 0 induces spatial learning and memory -MAP3K11 MLK3 EC 2.7.11.25; KINASE; Kinase, protein; Protein kinase, Ser/Thr (non-receptor); Protein kinase, TKL Q16584 4296 11q13.1 human T277-p 448263 LAREWHKtTQMSAAG PK_Tyr_Ser-Thr molecular association, regulation; enzymatic activity, induced cell differentiation, induced GEFT(INDUCES) 11053428; 18851832; 21965325 8 0 0 -Kcnb1 Kv2.1 Channel, cation; Channel, ligand-gated; Channel, potassium; Membrane protein, integral; Membrane protein, multi-pass P15387 25736 3q42 rat S484-p 473560 KVQDNHLsPNKWKWT Kv2channel activity, inhibited 16917065 1 6 5 -ITGAE ITGAE Membrane protein, integral; Motility/polarity/chemotaxis P38570 3682 17p13.2 human S1163-p 334535807 YQQLNLEsIRKAQLK intracellular localization cell adhesion, induced 29021139 1 0 0 recruit Pxn at the contact area, outside-in signaling ; clustering and lysosome relocalization -Lipe HSL EC 3.1.1.79; Lipase P54310 16890 7 A3|7 13.78 cM mouse S358-p 1872513511 GGFVAQTsKSHEPYL Abhydrolase_3 enzymatic activity, induced autophagy, inhibited 33657384; 34695513 6 1 0 -ITIH2 ITIH2 Inhibitor; Secreted; Secreted, signal peptide P19823 3698 10p14 human S60-p 454327 QRSLPGEsEEMMEEV carcinogenesis, induced 36114575 0 15 0 -ERBB3 HER3 EC 2.7.10.1; KINASE; Kinase, protein; Membrane protein, integral; Oncoprotein; Protein kinase, TK; Protein kinase, tyrosine (receptor) P21860 2065 12q13.2 human Y1289-p 449858 CPASEQGyEEMRAFQ activity, induced; molecular association, regulation; enzymatic activity, induced carcinogenesis, induced; cell growth, induced; cell motility, induced; apoptosis, inhibited; signaling pathway regulation; cell growth, altered PIK3R2(INDUCES); PIK3R1(INDUCES) 16729043; 20227043; 21725367; 21918175; 31978707; 32029900; 34320350; 34385295 30 10 125 -DNM1L DRP1 Apoptosis; EC 3.6.5.5; Endoplasmic reticulum; Hydrolase; Microtubule-binding; Mitochondrial; Motor O00429 10059 12p11.21 human T595-p 28716001 NWRGMLKtSKAEELL activity, induced autophagy, induced 23813973 1 1 0 induce mitochondrial fragmentation -Srsf1 SF2 RNA splicing; RNA-binding; Spliceosome NP_001103022 689890 10q26 rat S234-p 468704 SPRRSRGsPRYSPRH intracellular localization 18658135 2 41 16 inhibits tau exon 10 inclusion, and increases 3R-tau production -Cttn Cortactin Actin-binding; Cytoskeletal; Motility/polarity/chemotaxis NP_001385572 60465 1q41-q42 rat T145-p 41425400 GFEYQGKtEKHASQK HS1_rep molecular association, regulation cell motility, inhibited; cytoskeletal reorganization ACTB(DISRUPTS) 26033110; 30570111 2 1 0 decrease actin bundling, altered higher order structure of dynamin1-cort complex, deformed lamelipodia and short filopodia; phospho-mimetic mutant shows atypical growth cone filopodia -CGAS cGAS EC 2.7.7.86 Q8N884 115004 6q13 human R124-m2 1881215700 RAGSCRQrGARCSTK molecular association, regulation DNA(DISRUPTS) 33762328 1 1 0 -Mdm4 MDM4 EC 6.3.2.-; Ligase; UBIQUITIN LIGASE; Ubiquitin conjugating system; Ubiquitin ligase O35618 17248 1 E4|1 57.75 cM mouse S341-p 470031 SKLTHSLsTSNITAI molecular association, regulation cell cycle regulation; signaling pathway regulation 14-3-3 gamma(INDUCES) 22556425; 24190973 12 7 3 -KRT8 K8 Cytoskeletal P05787 3856 12q13.13 human Y267-p 457880 IAEVKAQyEDIANRS Filament cytoskeletal reorganization 24003221 1 10 451 -BCL2L11 BIM Apoptosis O43521 10018 2q13 human K3-ub 25087001 _____MAkQPSDVSS protein degradation apoptosis, inhibited 14657036 3 0 0 -IGF1R IGF1R EC 2.7.10.1; KINASE; Kinase, protein; Membrane protein, integral; Protein kinase, TK; Protein kinase, tyrosine (receptor) P08069 3480 15q26.3 human Y1161-p 448386 FGMTRDIyETDYYRK PK_Tyr_Ser-Thr molecular association, regulation; receptor internalization, altered; protein conformation; phosphorylation; enzymatic activity, induced carcinogenesis, induced; autophagy, induced; cell growth, inhibited; apoptosis, induced; cell motility, induced; apoptosis, inhibited; signaling pathway regulation Src(INDUCES) 11591350; 16037379; 16793764; 21685939; 30833419; 34921013; 36149602; 7588225 22 31 455 -ERG ERG DNA-binding; Oncoprotein; Transcription factor P11308 2078 21q22.2 human S39-p 50259800 EMTASSSsDYGQTSK protein degradation; molecular association, regulation cell motility, inhibited SPOP(INDUCES) 26344095 1 1 0 -Myo3a MYO3A Actin-binding; EC 2.7.11.1; KINASE; Kinase, protein; Motor; Protein kinase, STE; Protein kinase, Ser/Thr (non-receptor) Q8K3H5 667663 2|2 A3 mouse S332-p 36841903 KKGNLNRsLISSLKD enzymatic activity, induced 21895655 1 1 0 -HDAC4 HDAC4 DEACETYLASE; Deacetylase; EC 3.5.1.98; Hydrolase; Nuclear receptor co-regulator; SUMO LIGASE P56524 9759 2q37.3 human S266-p 4737976 KVAERRSsPLLRRKD activity, induced; intracellular localization transcription, inhibited 23652597; 29472387; 30661366 4 20 1 transcription of MEF2 target genes RhoB and Klf2 -NOTCH1 Notch 1 Membrane protein, integral; Motility/polarity/chemotaxis; Oncoprotein; Receptor, misc.; Transcription factor P46531 4851 9q34.3 human S2521-p 467287 PESPDQWsSSSPHSN protein degradation; receptor inactivation, altered 16880534 1 0 0 Alanine mutation of 4 serines (S2522/S2523/S2524/S2525) causes increased protein stability. -Ctnnb1 CTNNB1 Actin-binding; Cell adhesion; Motility/polarity/chemotaxis; Nuclear receptor co-regulator; Oncoprotein; Transcription factor Q02248 12387 9 F4|9 72.19 cM mouse S552-p 472273 QDTQRRTsMGGTQQQ intracellular localization cell differentiation, inhibited; carcinogenesis, induced; transcription, induced; signaling pathway regulation; transcription, altered 17237784; 20230753; 32102932; 34580275; 34642308 44 64 9 regulates the Wnt signaling pathway -BAIAP2 IRSp53 Actin-binding; Motility/polarity/chemotaxis Q9UQB8 10458 17q25.3 human T340-p 2049593 LSDSYSNtLPVRKSV molecular association, regulation cytoskeletal reorganization 14-3-3 zeta(INDUCES) 19933840 1 30 24 -USP25 USP25 DEUBIQUITINASE; EC 3.4.19.12; Protease; Ubiquitin conjugating system; Ubiquitin-specific protease Q9UHP3 29761 21q21.1 human S745-p 40407602 PEYLEQPsRSDFSKH ubiquitination; enzymatic activity, inhibited 25755282 1 0 0 in vitro deubiquitination assays -CD274 PD-L1 Membrane protein, integral Q9NZQ7 29126 9p24.1 human T290-p 56667601 SDTHLEEt_______ protein stabilization; molecular association, regulation carcinogenesis, induced SPOP(DISRUPTS) 35385574 2 2 0 inhibits ubiquitination -IQCB1 IQCB1 Cell development/differentiation Q15051 9657 3q13.33|3q21.1 human K33-ub 95155303 PVILLKLkEIINITP intracellular localization cell cycle regulation; cytoskeletal reorganization 28498859 1 3 0 regulation of cilia formation -ARHGEF7 ARHGEF7 iso1 GEF; GEF, Rac/Rho; Motility/polarity/chemotaxis Q14155-1 8874 13q34 human S525-p 455681 EEFASRKsTAALEED RhoGEF67_u2 activity, induced cytoskeletal reorganization 14557270 3 19 2 S525/T526 phosphorylation regulates Rac1 activation and growth cone extension/retraction. -Eef2k EEF2K EC 2.7.11.20; KINASE; Kinase, protein; Protein kinase, Ser/Thr (non-receptor); Protein kinase, atypical; Translation P70531 25435 1q36 rat S365-p 447827 SPRIRTLsGSRPPLL phosphorylation 33191388 16 11 20 inhibits phosphorylation of EEf2 -Cd3e CD3E Membrane protein, integral; Receptor, misc. P22646 12501 9 A5.2|9 24.84 cM mouse Y181-p 448917 RKGQRDLySGLNQRA ITAM molecular association, regulation PIK3R1(INDUCES) 9312149 4 15 398 -CRYAA CRYA1 Chaperone; Heat shock protein P02489 1409 21q22.3 human T148-p 452108 FCGPKIQtGLDATHA HSP20 activity, induced; molecular association, regulation; intracellular localization; phosphorylation apoptosis, inhibited; transcription, inhibited CRYA1(DISRUPTS) 29467334; 34071438; 35168949; 35669493 5 5 0 -PPARA PPAR-alpha DNA-binding; Nuclear receptor; UBIQUITIN LIGASE Q07869 5465 22q13.31 human S179-p 457549 RFGRMPRsEKAKLKA transcription, altered 15131257 2 0 0 -NUP50 NUP50 Nuclear import; Nucleoporin Q9UKX7 10762 22q13.31 human S315-p 4957816 TQSKPVSsPFPTKPL molecular association, regulation KPNB1(DISRUPTS) 19767751 1 2 1 -ARID4A RbBP1 Adaptor/scaffold P29374 5926 14q23.1 human S1007-p 17743401 QHNFSVAsPLTLSQD molecular association, regulation Rb(DISRUPTS) 21148318 1 1 0 -JAK2 JAK2 EC 2.7.10.2; KINASE; Kinase, protein; Oncoprotein; Protein kinase, TK; Protein kinase, tyrosine (non-receptor) O60674 3717 9p24.1 human Y201-p 470070 DQTPLAIyNSISYKT FERM_F2 molecular association, regulation; phosphorylation carcinogenesis, induced; cell growth, induced; apoptosis, inhibited; signaling pathway regulation STAT5A(INDUCES); SHP-2(INDUCES) 22837531 3 1 0 induces phosphorylation of JAK2, STAT5 and SHP2 -MAP2K2 MEK2 EC 2.7.12.2; KINASE; Kinase, protein; Protein kinase, STE; Protein kinase, dual-specificity (non-receptor) P36507 5605 19p13.3 human T13-gl 1871246004 KPVLPALtINPTIAE protein stabilization; phosphorylation cell cycle regulation; carcinogenesis, induced; cell motility, induced; cell growth, induced; signaling pathway regulation 33226073 1 1 0 promotes phosphorylation at MEK2-T394, activates MEK2/ERK1/2 signaling cascade -Tp53 p53 Activator; DNA-binding; Motility/polarity/chemotaxis; Nuclear receptor co-regulator; Transcription factor; Tumor suppressor P02340 22059 11 B3|11 42.83 cM mouse K383-ac 486382 RHKKTMVkKVGPDSD activity, induced apoptosis, induced; transcription, induced 25758227; 33323382 12 2 1 P53K Q/- mice died prematurely due to anemia, loss of hematopoiesis stem cells, Loss of stem cells in the testis, activation in p53 KQ/- mice without robust p53 stabilization,p53-KQ/- mutant leads to effective suppression of tumor development in a pancreatic ductal adenocarcinoma mouse model, mutant proteins extended the life-span of a PDAC mouse model -Cebpa C/EBP-alpha DNA-binding; Transcription factor P05554 24252 1q21 rat K159-sm 2793923 ALRPLVIkQEPREED molecular association, regulation transcription, inhibited HDAC3(INDUCES) 23639777 5 1 0 -PDE4C PDE4C iso2 EC 3.1.4.53; Nucleotide Metabolism - purine; Phosphodiesterase Q08493-2 5143 19p13.11 human S535-p 471381 YQSKIPRsPSDLTNP enzymatic activity, inhibited 11030732 1 4 0 -AP4E1 AP4E1 Adaptor/scaffold Q9UPM8 23431 15q21.2 human S847-p 15407703 DKELKKFsLTSELLD receptor recycling, inhibited 21810154 1 0 0 -RACK1 RACK1 Adaptor/scaffold; G protein; G protein, heterotrimeric; G protein, heterotrimeric beta; Motility/polarity/chemotaxis; Nuclear receptor co-regulator P63244 10399 5q35.3 human K257-ub 10840127 AATGPSIkIWDLEGK WD40 protein degradation carcinogenesis, induced 33323973 1 7 54 -IRS1 IRS1 Adaptor/scaffold; Motility/polarity/chemotaxis P35568 3667 2q36.3 human S527-p 447561 RFRKRTHsAGTSPTI intracellular localization signaling pathway regulation 16914728; 34253290; 35810470 7 23 0 disassociation of IRS2 from plasma membrane to cytosol; via cell fractionation experiments; regulates insulin signaling; limits PM-associated PI3K and PIP3 synthesis -RAD9A RAD9A Apoptosis; Cell cycle regulation; DNA replication; Deoxyribonuclease; EC 3.1.11.2 Q99638 5883 11q13.2 human T355-p 449818 EPSTVPGtPPPKKFR cell cycle regulation 12734188; 20305300; 24376897 5 8 11 phosphorylation increases as cells enter mitosis, important for exiting the damage-induced G2/M checkpoint -PPP1R3F PPP1R3F Membrane protein, integral; Protein phosphatase, regulatory subunit Q6ZSY5 89801 Xp11.23 human S400-p 22650302 EEGDVPRsSPPVAFT signaling pathway regulation 21668450 0 1 0 regulation of glycogen synthesis via R3F-PP1 signaling in astrocytoma cells -MAPK14 P38A EC 2.7.11.24; KINASE; Kinase, protein; Protein kinase, CMGC; Protein kinase, Ser/Thr (non-receptor) Q16539 1432 6p21.31 human T123-p 471074 IVKCQKLtDDHVQFL Pkinase molecular association, regulation; enzymatic activity, inhibited; phosphorylation cell differentiation, altered MAPKAPK2(DISRUPTS); MKK6(DISRUPTS) 17055984 1 0 0 Phosphorylation leads to less interaction with activator (MKK6) and substrates (MAPKAPK2). -Trpv4 TRPV4 Channel, cation; Membrane protein, integral; Membrane protein, multi-pass Q9EPK8 63873 5|5 F mouse Y110-p 4777176 PMDSLFDyGTYRHHP activity, induced; intracellular localization 19033444 3 4 0 -NASP NASP iso2 Cell cycle regulation P49321-2 4678 1p34.1 human S158-p 476187 TEEMPNDsVLENKSL molecular association, regulation TRAF6(DISRUPTS) 29733298 1 17 0 mounting of an effective immune response during sepsis -NPM1 NPM1 Nucleolus; Oncoprotein; RNA-binding; Translation P06748 4869 5q35.1 human S88-p 4169620 MSVQPTVsLGGFEIT Nucleoplasmin protein stabilization; molecular association, regulation ARF1(INDUCES) 23851489 2 12 0 increase ARF protein stabilization -CASP9 CASP9 Apoptosis; EC 3.4.22.62; Protease P55211 842 1p36.21 human S144-p 458346 GDVGALEsLRGNADL activity, inhibited apoptosis, altered 16287866 1 0 0 -ETV4 ETV4 DNA-binding P43268 2118 17q21.31 human K260-sm 3144815 PGAGVVIkQEQTDFA ETS_PEA3_N transcription, inhibited 17585876 4 1 0 -Sntb2 SNTB2 Adaptor/scaffold; Dystrophin complex; Extracellular matrix Q61235 20650 8 D3|8 53.38 cM mouse S90-p 471148 PAGEASAsPPVRRVR molecular association, regulation; intracellular localization exocytosis, altered PTPRN(INDUCES) 20886068 1 82 5 -NRP1 NRP1 Membrane protein, integral; Receptor, misc. O14786 8829 10p11.22 human Y297-p 21656101 QITASSQySTNWSAE F5_F8_type_C molecular association, regulation; phosphorylation cell motility, induced NRP1(INDUCES) 21653826 1 0 0 binding to NRP1 is required for FAK signaling -Cryab CRYAB Chaperone; Heat shock protein P23928 25420 8q23 rat S19-p 447728 RPFFPFHsPSRLFDQ Crystallin protein degradation; intracellular localization; phosphorylation apoptosis, altered; signaling pathway regulation 12574148; 22870022; 24159092; 27851782; 33220080 26 16 2 localization of phosphorylated alpha-BCs in the diabetic retina -EPAS1 HIF2A DNA-binding; Transcription factor Q99814 2034 2p21 human S790-p 1883618704 PQPPSAIsPGENSKS protein stabilization; molecular association, regulation carcinogenesis, induced; cell motility, induced PIN1(INDUCES) 37473874 1 1 0 -Erbb3 HER3 EC 2.7.10.1; KINASE; Kinase, protein; Membrane protein, integral; Oncoprotein; Protein kinase, TK; Protein kinase, tyrosine (receptor) Q62799 29496 7q11 rat Y1257-p 449860 GTTPDEDyEYMNRRR molecular association, regulation; phosphorylation PIK3CB(INDUCES); PIK3R1(INDUCES) 11546794 3 0 16 induces phosphorylation of Akt1. -Xbp1 XBP1 iso2 DNA-binding; Transcription factor O35426-2 22433 mouse K276-sm 13875701 SQTNVVVkIEEAPLS intracellular localization transcription, inhibited 20408817; 34421344 2 0 0 -Rela NFkB-p65 DNA-binding; Nuclear receptor co-regulator; Transcription factor Q7TQN4 309165 1q43 rat S311-p 449966 RTYETFKsIMKKSPF apoptosis, inhibited 21550382 17 2 1 induces cell survival -IRF1 IRF1 Transcription factor; Tumor suppressor P10914 3659 5q31.1 human K117-ub 31914115 RMLPPLTkNQRKERK protein degradation; molecular association, regulation DNA(DISRUPTS) 23134341 1 2 0 -CTDSPL2 CTDSPL2 EC 3.1.3.-; Motility/polarity/chemotaxis; PHOSPHATASE; Phosphatase Q05D32 51496 15q15.3-q21.1 human S104-p 3205830 ISRVRRKsQVNGEAG cell cycle regulation; carcinogenesis, induced; cell motility, induced; cell growth, induced; transcription, inhibited 34813892 1 24 201 -ETFB ETFB Mitochondrial; Oxidoreductase P38117 2109 19q13.41 human K200-m2 3899873 ATLPNIMkAKKKKIE ETF enzymatic activity, inhibited 25416781 1 1 5 inhibitory effect on the transfer of electrons -Syngap1 SynGAP GAP; GAP, Ras F6SEU4 240057 17|17 A3.3 mouse S788-p 19014968 MDMARLPsPTKEKPP DUF3498 protein conformation; activity, inhibited translation, induced; signaling pathway regulation 25533468; 36315645 2 3 20 regulates mTORC1 signalling; S788D and T790D mutations inhibit Rap2 GAP and HRas GAP activities of SynGAP -GARS1 GARS Aminoacyl-tRNA synthetase; EC 6.1.1.14; Ligase; Mitochondrial; Translation; Translation regulation P41250 2617 7p14.3 human T544-p 1352793600 KGEFTIEtEGKTFQL tRNA-synt_2b molecular association, regulation; intracellular localization NFkB-p100(INDUCES) 30471104 1 0 0 -PPP1R14C KEPI Inhibitor; Protein phosphatase, regulatory subunit Q8TAE6 81706 6q25.1 human T73-p 10296602 RHQQGKVtVKYDRKE PP1_inhibitor molecular association, regulation; phosphorylation cell cycle regulation; carcinogenesis, induced; cell motility, induced; cell growth, induced; cytoskeletal reorganization PPP1CA(INDUCES) 25531779; 35090098 3 4 1 -Pelp1 PELP1 Nuclear receptor co-regulator; Transcription, coactivator/corepressor Q9DBD5 75273 11|11 B3 mouse T751-p 453708 PVLAPSGtPPPSIPP protein degradation 26627258 1 32 0 E2 has a protective effect of restoring the PELP1 levels by blocking GSK3B activation. -NCAPD3 NCAPD3 Cell cycle regulation P42695 23310 11q25 human T1415-p 10790749 VTKRAIStPEKSISD molecular association, regulation; phosphorylation cell cycle regulation; chromatin organization, altered PLK1(INDUCES) 21498573; 30626720 3 4 4 -SHARPIN SHARPIN Apoptosis Q9H0F6 81858 8q24.3 human S165-p 3245774 PEADLPRsPGNLTER protein degradation; ubiquitination; intracellular localization transcription, induced 33392484 1 15 6 causes ubiquitination and protein degradation of IKB, and NF-kB translocation to the nucleus -Git1 GIT1 GAP; GAP, ARF; Motility/polarity/chemotaxis Q68FF6 216963 11|11 B5 mouse S419-p 482779 TRNNRARsMDSSDLS GIT_CC molecular association, regulation CAMK2A(INDUCES) 23352984 1 40 7 synapsin I density is decreased in S419A mutant; interaction is important for premature synapse formation. -Sod2 SOD2 EC 1.15.1.1; Mitochondrial; Oxidoreductase P09671 20656 17 A1|17 8.75 cM mouse K68-sc 33340970 NLNATEEkYHEALAK Sod_Fe_N enzymatic activity, inhibited 36654268 1 2 0 -CALD1 Caldesmon iso4 Actin-binding Q05682-4 800 7q33 human S534-p 448466 QSVDKVTsPTKV___ molecular association, regulation cell motility, induced; cytoskeletal reorganization leupaxin(INDUCES) 26079947 19 19 0 -EDNRA EDNRA GPCR, family 1; Membrane protein, integral; Membrane protein, multi-pass; Motility/polarity/chemotaxis; Receptor, GPCR P25101 1909 4q31.22-q31.23 human S425-p 2911707 DRSSHKDsMN_____ receptor desensitization, induced 24064210 1 2 0 Lack of S397, T403 and S404 influences desensitization to a greater extent compared than S391, S393, and T396 -L1CAM NCAM-L1 Cell adhesion; Membrane protein, integral P32004 3897 Xq28 human T1172-p 4702537 ARPMKDEtFGEYRSL Bravo_FIGEY protein degradation; protein conformation cell motility, altered 20335502 2 6 7 -IFNLR1 IL28RA Membrane protein, integral Q8IU57 163702 1p36.11 human K320-ub 1883375200 TQQTRWKkDLAEDEE protein degradation 36379255 1 0 0 -Mos MOS EC 2.7.11.1; KINASE; Kinase, protein; Oncoprotein; Protein kinase, Other; Protein kinase, Ser/Thr (non-receptor) P00536 17451 4 A1|4 2.16 cM mouse S25-p 448659 SVDSRSCsIPLVAPR enzymatic activity, inhibited 9632642 3 1 0 in vitro -ATIC ATIC Cofactor and Vitamin Metabolism - one carbon pool by folate; EC 2.1.2.3; EC 3.5.4.10; Hydrolase; METHYLTRANSFERASE; Methyltransferase; Mitochondrial; Nucleotide Metabolism - purine P31939 471 2q35 human Y104-p 456299 RVVACNLyPFVKTVA MGS enzymatic activity, induced 18845790 1 8 105 -NDC80 HEC1 Cell cycle regulation O14777 10403 18p11.32 human S5-p 474510 ___MKRSsVSSGGAG cell cycle regulation 17129782; 36897279 2 1 0 -PAK2 PAK2 EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, STE; Protein kinase, Ser/Thr (non-receptor) Q29502 100009535 rabbit T402-p 448300 PEQSKRStMVGTPYW Pkinase enzymatic activity, induced 18984590 15 2 11 -TRIM28 TIF1B EC 6.3.2.-; KINASE; Kinase, protein; Ligase; Nuclear receptor co-regulator; Protein kinase, atypical; SUMO LIGASE; SUMO ligase; Transcription, coactivator/corepressor; UBIQUITIN LIGASE; Ubiquitin conjugating system; Ubiquitin ligase Q13263 10155 19q13.43 human K774-ub 12315244 RMFKQFNkLTEDKAD protein degradation 26676607 0 6 13 -FOS Fos DNA-binding; Motility/polarity/chemotaxis; Oncoprotein; Transcription factor P01100 2353 14q24.3 human T331-p 448484 CTPVVTCtPSCTAYT carcinogenesis, induced; transcription, induced 23667255 4 0 0 nuclear import of HBXIP -LIMK2 LIMK2 EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, Ser/Thr (non-receptor); Protein kinase, TKL P53671 3985 22q12.2 human T505-p 448683 NDRKKRYtVVGNPYW PK_Tyr_Ser-Thr activity, induced; protein stabilization; molecular association, regulation; intracellular localization; enzymatic activity, induced cell cycle regulation; cell adhesion, induced; cytoskeletal reorganization ROCK2(INDUCES) 11171090; 19099536; 21423216; 22492986; 23934191 17 1 1 -PYCARD PYCARD Adaptor/scaffold; Tumor suppressor Q9ULZ3 29108 16p11.2 human Y146-p 465096 KVLTDEQyQAVRAEP CARD molecular association, regulation PYCARD(INDUCES) 33568399 4 2 4 mediated/regulates pyroptosis -Ahcyl1 AHCYL1 Amino Acid Metabolism - cysteine and methionine; EC 3.3.1.1; Hydrolase; Other Amino Acids Metabolism - selenoamino acid Q80SW1 229709 3 F2.3|3 46.83 cM mouse S74-p 467246 ISQSSTDsYSSAASY molecular association, regulation PIP5K1A(INDUCES); IP3R1(INDUCES) 16793548; 26509711 5 1 0 -Mdm2 MDM2 EC 6.3.2.-; EC 6.3.2.19; Inhibitor; Ligase; NEDDYLATION LIGASE; Neddylation Ligase; Nucleolus; Oncoprotein; UBIQUITIN LIGASE; Ubiquitin conjugating system; Ubiquitin ligase P23804 17246 10 D2|10 66.32 cM mouse T216-p 450150 SSSESTEtPSHQDLD molecular association, regulation 11359766 4 0 0 -MCRIP1 FAM195B C9JLW8 348262 17q25.3 human T30-p 9322247 PSSSEIFtPAHEENV FAM195 molecular association, regulation transcription, induced CTBP1(DISRUPTS) 25728771 2 5 14 freed CtBP binds to ZEB1, regulates epithelial-mesenchymal transition (EMT). -KHDRBS1 KHDRBS1 RNA-binding Q07666 10657 1p35.2 human T61-p 3194543 GARASPAtQPPPLLP molecular association, regulation DNA repair, induced; RNA splicing, induced PARP1(INDUCES) RNA(INDUCES) 36010841 1 6 0 -FBXW7 FBXW7 Motility/polarity/chemotaxis; Nucleolus; UBIQUITIN LIGASE; Ubiquitin conjugating system; Ubiquitin ligase Q969H0 55294 4q31.3 human S10-p 17337000 QELLSVGsKRRRTGG intracellular localization 20815813 1 1 0 -MIEN1 MIEN1 Apoptosis; Motility/polarity/chemotaxis Q9BRT3 84299 17q12 human Y39-p 48921821 PCGFEATyLELASAV Rdx carcinogenesis, induced; cell motility, induced 26272794 1 0 0 -MAP3K7 TAK1 EC 2.7.11.25; KINASE; Kinase, protein; Protein kinase, Ser/Thr (non-receptor); Protein kinase, TKL O43318 6885 6q15 human K158-ub 13310800 ALIHRDLkPPNLLLV PK_Tyr_Ser-Thr molecular association, regulation; enzymatic activity, induced transcription, induced; signaling pathway regulation IKKB(INDUCES); IKKG(INDUCES) 20038579; 22981905 3 0 0 regulation of IKKs and NF-kB activation during Dox-induction. -YAP1 YAP1 Oncoprotein; Transcription, coactivator/corepressor P46937 10413 11q22.1 human S163-p 3190657 TAQHLRQsSFEIPDD cell growth, induced; transcription, inhibited 28416665 2 11 14 sensitivity to gemcitabine -Hist1h2ail1 H3 DNA-binding Q6LED0 291159 17p11 rat K9-ac 463820 RTKQTARkSTGGKAP Histone molecular association, regulation transcription, induced DNA(INDUCES) 16081763; 17495236; 19476549; 26298192 230 26 341 -Map2 MAP2 iso3 Cytoskeletal; Motility/polarity/chemotaxis P15146-3 25595 9q32 rat T220-p 2999205 ISSARRTtRSEPIRR protein degradation; molecular association, regulation TUBA1A(DISRUPTS); TUBB(DISRUPTS) 12369833 2 1 0 -VIL1 Villin Actin-binding; Motility/polarity/chemotaxis P09327 7429 2q35 human Y60-p 454005 KTASSLSyDIHYWIG Gelsolin molecular association, regulation; intracellular localization cytoskeletal reorganization ACTB(INDUCES) 12269817; 15342783 3 0 0 -RBL2 Rb-like 2 Transcription, coactivator/corepressor; Tumor suppressor Q08999 5934 16q12.2 human T986-p 449737 QPSSAPPtPTRLTGA RB_B molecular association, regulation cell cycle regulation E2F4(DISRUPTS) 11157749 3 16 6 -Pparg PPAR-gamma DNA-binding; Nuclear receptor; Transcription factor P37238 19016 6 E3|6 53.41 cM mouse S112-p 448062 AIKVEPAsPPYYSEK sumoylation; molecular association, regulation; intracellular localization; activity, inhibited cell differentiation, inhibited; cell differentiation, altered; cell differentiation, induced; transcription, inhibited; cell growth, altered TAZ(INDUCES) 12777391; 14536066; 16534556; 18204460; 21994940; 26206105; 27341689; 31708444; 33539723; 33567272; 36840344 33 7 0 -Slc38a3 SLC38A3 Membrane protein, integral; Membrane protein, multi-pass; Transporter; Transporter, SLC family Q9JHZ9 252919 8q32 rat S52-p 19001700 KGFLQQSsSKEPHFT protein degradation; intracellular localization 21525297 1 0 0 protein internalization -Relb RELB Transcription factor Q04863 19698 7 A3|7 9.93 cM mouse S368-p 455656 RLTDGVCsEPLPFTY RHD_dimer molecular association, regulation transcription, altered NFkB-p105(INDUCES); NFkB-p100(INDUCES) 12874295 1 0 0 -ILF3 NFAT90 DNA-binding; Nucleolus; RNA-binding; Transcription factor Q12906 3609 19p13.2 human T188-p 17734001 EKVLAGEtLSVNDPP DZF intracellular localization 24920670 3 1 0 cytoplasmic retention, which increases its association with and assembly of large RNA granules -Tbc1d4 AS160 GAP; GAP, Rab Q8BYJ6 210789 14|14 E2.3 mouse S595-p 455920 RMRGRLGsMDSFERA molecular association, regulation; phosphorylation IRAP(DISRUPTS); 14-3-3 gamma(INDUCES) 19923418; 33872597 21 68 253 affects phosphorylation of other sites by AKT -ENO1 ENO1 Carbohydrate Metabolism - glycolysis and gluconeogenesis; EC 4.2.1.11; Lyase; Transcription, coactivator/corepressor P06733 2023 1p36.23 human S282-p 22777189 QLADLYKsFIKDYPV Enolase_C enzymatic activity, inhibited 27153534 1 4 11 -Mapkapk2 MAPKAPK2 EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, CAMK; Protein kinase, Ser/Thr (non-receptor) P49138 17164 1|1 E4 mouse T320-p 448273 QSTKVPQtPLHTSRV intracellular localization; enzymatic activity, induced transcription, induced 33504618; 7592979; 9628873 31 14 38 induces immunosuppression -Espl1 separase EC 3.4.22.49; Protease P60330 105988 15|15 F3 mouse S1120-p 4270957 PIQSSVNsSPVLKTK molecular association, regulation cytoskeletal reorganization 23857768 1 0 0 S1120 T1341 AA mutant -fewer cold-stable kinetochore-microtubule attachments and lacks tension -SPHK2 SPHK2 EC 2.7.1.91; Kinase, lipid; Lipid Metabolism - sphingolipid Q9NRA0 56848 19q13.33 human T614-p 477182 AFRLEPLtPRGVLTV YegS_C cell motility, altered 17311928 1 1 0 -PEA15 PEA-15 Apoptosis; Motility/polarity/chemotaxis Q15121 8682 1q23.2 human S104-p 455750 TKLTRIPsAKKYKDI molecular association, regulation; intracellular localization; protein conformation carcinogenesis, induced; cell motility, induced; apoptosis, inhibited; transcription, induced; autophagy, altered; signaling pathway regulation FADD(INDUCES) 17700518; 20452983; 21285289; 30569123; 34241740; 34615962; 34997083 13 27 322 -CELF1 CELF1 Cell development/differentiation; RNA processing; RNA-binding Q92879 10658 11p11.2 human S302-p 3347301 TSSGSSPsSSSSNSV molecular association, regulation RNA splicing, altered; translation, altered; translation, induced eIF2-beta(INDUCES); eIF2-alpha(INDUCES); Elf-2(INDUCES) RNA(INDUCES); RNA(DISRUPTS) 18570922; 24151077; 26100016; 31383751 6 1 0 5'-UTR of p53 mRNA; increases CUGBP1 binding to C/EBP beta and p21 mRNAs ; phosphorylation induces binding to active elf2; translational CUGBP1-eIF2 complexes during normal muscle differentiation; splicing regulation in diabetes -NCOR1 N-CoR1 Nuclear receptor co-regulator; Transcription, coactivator/corepressor O75376 9611 17p12-p11.2 human S2436-p 468249 SAQYETLsDSDD___ protein stabilization; molecular association, regulation carcinogenesis, induced; transcription, inhibited DNA(INDUCES) 22675025 1 19 5 needed for transcriptional repression of IP-10 protein -PGR PR DNA-binding; Nuclear receptor; Transcription factor P06401 5241 11q22.1 human R637-me 1876957800 AGMVLGGrKFKKFNK protein degradation; receptor recycling, induced cell motility, induced; cell growth, induced; transcription, induced 32563156 1 0 0 -ERG ERG DNA-binding; Oncoprotein; Transcription factor P11308 2078 21q22.2 human K355-me 1875818000 ARRWGERkSKPNMNY Ets activity, induced; molecular association, regulation; protein conformation carcinogenesis, induced; cell growth, induced; transcription, induced DNA(INDUCES) 34230470 1 0 0 -MAP3K5 ASK1 EC 2.7.11.25; KINASE; Kinase, protein; Protein kinase, STE; Protein kinase, Ser/Thr (non-receptor) Q99683 4217 6q23.3 human T842-p 450004 CTETFTGtLQYMAPE Pkinase transcription, altered 17937911 3 0 0 -YWHAZ 14-3-3 zeta Adaptor/scaffold; Motility/polarity/chemotaxis P63104 7534 8q22.3 human K120-ac 3649468 ESKVFYLkMKGDYYR 14-3-3 molecular association, regulation apoptosis, induced KIF11(DISRUPTS); ATG9A(DISRUPTS); AS160(DISRUPTS); BAD(DISRUPTS) 25770209 1 6 10 -Abl1 Abl EC 2.7.10.2; KINASE; Kinase, protein; Oncoprotein; Protein kinase, TK; Protein kinase, tyrosine (non-receptor) P00520 11350 2 21.86 cM|2 B mouse Y393-p 450298 RLMTGDTyTAHAGAK PK_Tyr_Ser-Thr phosphorylation; enzymatic activity, induced cytoskeletal reorganization; signaling pathway regulation 10964922; 11847100; 12748290; 31914386 24 49 1642 induces phosphorylation of Doublecortin, induces Abl/Dcx signaling and hence neuritogenesis -Nfkbie IkB-epsilon DNA-binding; Inhibitor O54910 18037 17|17 B3 mouse S18-p 455580 ADDSQCDsGIESLRS protein degradation 10497169 1 6 6 -Tbk1 TBK1 EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, Other; Protein kinase, Ser/Thr (non-receptor) Q9WUN2 56480 10|10 D2 mouse K401-ub 31033006 YEKISLPkIHPRYDL TBK1_CCD1 autophagy, induced 33164878 3 1 0 Parkin mediated mitophagy -PDE4D PDE4D iso2 EC 3.1.4.53; Nucleotide Metabolism - purine; Phosphodiesterase Q08499-2 5144 5q11.2-q12.1 human S54-p 458388 VHSQRREsFLYRSDS enzymatic activity, induced 15131123; 16973330; 20106966; 8663227 10 21 1 -H1-4 H1E DNA-binding P10412 3008 6p22.2 human S36-p 456059 GAAKRKAsGPPVSEL cell cycle regulation DNA(DISRUPTS) 21852232 2 70 36 contributes to mitotic progression; dissociates from mitotic chromatin -NTRK1 TrkA iso2 EC 2.7.10.1; KINASE; Kinase, protein; Membrane protein, integral; Oncoprotein; Protein kinase, TK; Protein kinase, tyrosine (receptor) P04629-2 4914 1q23.1 human Y670-p 449759 FGMSRDIySTDYYRV PK_Tyr_Ser-Thr enzymatic activity, induced 9099755 3 2 12 -Kcnb1 Kv2.1 Channel, cation; Channel, ligand-gated; Channel, potassium; Membrane protein, integral; Membrane protein, multi-pass P15387 25736 3q42 rat S607-p 473555 EATRFSHsPLASLSS Kv2channel intracellular localization; activity, inhibited neural plasticity 16917065; 21712386 7 6 0 regulates clustering/ regulating Kv2.1 channels; regulating neuronal function -Fer Fer EC 2.7.10.2; KINASE; Kinase, protein; Oncoprotein; Protein kinase, TK; Protein kinase, tyrosine (non-receptor) P70451 14158 17|17 E1.1 mouse Y402-p 457934 EPPPVVNyEEDARSV cell cycle regulation; cell motility, altered 18515860 2 39 613 -ARID4A RbBP1 Adaptor/scaffold P29374 5926 14q23.1 human K418-sm 12004425 HHHEPKVkEEKKDLE cell cycle regulation; cell growth, inhibited; transcription, inhibited 16479010 1 0 0 -MYLK smMLCK EC 2.7.11.18; KINASE; Kinase, protein; Protein kinase, CAMK; Protein kinase, Ser/Thr (non-receptor) Q15746 4638 3q21.1 human Y464-p 451414 QEGSIEVyEDAGSHY I-set molecular association, regulation; enzymatic activity, induced Cortactin(INDUCES) 11113114; 12408982 3 1 0 -Nphs1 NPHS1 Cell adhesion; Immunoglobulin superfamily; Membrane protein, integral Q9R044 64563 1q21 rat Y1153-p 1317600 AEVDPNYySMRDFSP cytoskeletal reorganization PIK3R1(INDUCES) 18033240 2 0 0 -Vim Vimentin Cytoskeletal; Motility/polarity/chemotaxis P20152 22352 2 A1|2 10.04 cM mouse S87-p 2301101 LQDSVDFsLADAINT Filament_head cytoskeletal reorganization 12458200 2 7 0 -HNF1A HNF1A DNA-binding; Transcription factor P20823 6927 12q24.31 human S249-p 451310 IQRGVSPsQAQGLGS molecular association, regulation transcription, induced DNA(INDUCES) 24821553 2 3 0 Regulates gluconeogenesis -Arc ARG3.1 Cytoskeletal; Motility/polarity/chemotaxis Q63053 54323 7q34 rat S206-p 149319101 PGEDGQPsPGVDTQI intracellular localization 28736134 1 0 0 cytosolic localization of Arc in hippocampal neurons -H3C1 H3 DNA-binding P68431 8350 6p22.2 human T11-p 455680 KQTARKStGGKAPRK Histone protein degradation; molecular association, regulation; acetylation; methylation; intracellular localization cell cycle regulation; DNA repair, induced; transcription, induced; transcription, inhibited; transcription, altered RNF8(INDUCES); H3(INDUCES); GCN5(INDUCES) 18243098; 20948546; 23844048; 28507061; 32112098 17 5 0 Acetylated MORC2 at K767 binds to H3T11P, downregulation of H3T11P and transcriptional repression of CDK1 and Cyclin B1 -NPM1 NPM1 Nucleolus; Oncoprotein; RNA-binding; Translation P06748 4869 5q35.1 human K292-ac 8537511 QDLWQWRkSL_____ NPM1-C molecular association, regulation; intracellular localization transcription, altered H3(INDUCES) 19581289 1 1 0 K212/215/229/230/257/267/292R mutant -NLRP3 NLRP3 Inhibitor Q96P20 114548 1q44 human S295-p 57761902 HKIVRKPsRILFLMD NACHT activity, inhibited 27548431 4 2 0 -TNC TNC Motility/polarity/chemotaxis; Secreted; Secreted, signal peptide P24821 3371 9q33.1 human K1882-ub 1877447401 KSSTITAkFTTDLDS protein degradation autophagy, induced 32732922 1 1 0 defective autophagy is key immunosuppressive factor in TNBC tumours -Sufu SUFU Adaptor/scaffold; Transcription, coactivator/corepressor; Tumor suppressor Q9Z0P7 24069 19 C3|19 38.85 cM mouse S342-p 4786843 LTHDRAPsRKDSLGS SUFU_C intracellular localization Exportin-1(DISRUPTS) 27849569 4 13 0 nuclear localization -Olig2 OLIG2 Oncoprotein; Transcription factor Q9EQW6 50913 16 C3.3|16 52.6 cM mouse K27-sm 1869334002 LFLPARSkGGSSSGF molecular association, regulation cell cycle regulation; carcinogenesis, induced; apoptosis, inhibited; DNA repair, inhibited; transcription, inhibited HDAC1(INDUCES) DNA(INDUCES) 32483381 1 1 0 -PINK1 PINK1 EC 2.7.11.1; KINASE; Kinase, protein; Membrane protein, integral; Mitochondrial; Protein kinase, Other; Protein kinase, Ser/Thr (non-receptor) Q9BXM7 65018 1p36.12 human T313-p 23003808 EGLGHGRtLFLVMKN Pkinase enzymatic activity, induced 22238344 1 1 0 contributes to activation, regulation of mitochondrial transport, abnormal mitochondrial distribution in neurons -TP63 p63 DNA-binding; Transcription factor Q9H3D4 8626 3q28 human S162-p 451601 TFDALSPsPAIPSNT protein stabilization; intracellular localization 23420876 6 2 0 nuclear stabilization of phosphorylated p63 in response to paclitaxel, partially relocates to the mitochondria -CCAR2 DBC-1 Apoptosis; Mitochondrial; Nuclear receptor co-regulator; RNA-binding; Tumor suppressor Q8N163 57805 8p21.3 human K215-ac 11324960 GGEPWGAkKPRHDLP molecular association, regulation; intracellular localization apoptosis, induced; transcription, inhibited SIRT1(DISRUPTS) 23892437; 24126058 2 4 0 -CSF2RB CSF2RB Membrane protein, integral; Receptor, cytokine P32927 1439 22q12.3 human K473-ub 57676503 YGYRLRRkWEEKIPN protein degradation 24086733 1 0 0 -PAK2 PAK2 EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, STE; Protein kinase, Ser/Thr (non-receptor) Q13177 5062 3q29 human S141-p 448295 TVKQKYLsFTPPEKD enzymatic activity, induced carcinogenesis, induced; cell adhesion, induced; apoptosis, inhibited; transcription, induced; signaling pathway regulation 21177766; 35986102; 36319849 17 84 76 induces the MAPK pathway -DNMT1 DNMT1 Amino Acid Metabolism - cysteine and methionine; Cell development/differentiation; EC 2.1.1.37; METHYLTRANSFERASE; Methyltransferase; Methyltransferase, DNA; Transcription regulation P26358 1786 19p13.2 human K1117-ac 474640 GKGKGKGkGKPKSQA cell cycle regulation; transcription, inhibited 21947282 1 1 19 -Dok1 DOK1 Adaptor/scaffold; Motility/polarity/chemotaxis P97465 13448 6 C3|6 35.94 cM mouse Y376-p 448368 PAPPRGLyDLPQEPR cell cycle regulation; cell motility, altered 18515860 2 12 356 -Eif4e EIF4E Translation; Translation initiation P63073 13684 3 G3|3 64.3 cM mouse S209-p 447776 DTATKSGsTTKNRFV molecular association, regulation; protein conformation carcinogenesis, induced; cell motility, induced; signaling pathway regulation; neural plasticity; translation, altered; apoptosis, inhibited; translation, induced; cell growth, altered; translation, inhibited eIF4G(INDUCES); CTNNB1(INDUCES) RNA(INDUCES) 18055695; 20679199; 22544393; 24909168; 25915475; 31968247; 34032633; 35842012; 35877722; 37250335; 9878069 64 4 0 regulates Wnt signaling pathway -HES1 HES1 Cell development/differentiation; Motility/polarity/chemotaxis; Transcription factor Q14469 3280 3q29 human K86-ub 22245547 DILEMTVkHLRNLQR HLH protein degradation cell differentiation, induced 29070679 1 1 0 -SERPINA3 SERPINA3 Secreted; Secreted, signal peptide P01011 12 14q32.13 human K416-ac 464676 QNIFFMSkVTNPKQA Serpin molecular association, regulation DNA(INDUCES) 7782318 1 0 0 -AKT1 Akt1 EC 2.7.11.1; KINASE; Kinase, protein; Oncoprotein; Protein kinase, AGC; Protein kinase, Ser/Thr (non-receptor) Q01314 280991 cow S473-p 447855 RPHFPQFsYSASATA Pkinase_C activity, induced; intracellular localization; enzymatic activity, induced cell growth, altered 12167717; 16195541 1956 25 44 Translocation to the plasma membrane leads to phosphorylation. ; PI3K, Akt and mTOR activation are required for 5-HT-induced proliferatioin. Wortmanin LY294002 and NL-71-101 dose-dependently inhibited 5HT induced proliferation. -IRAK4 IRAK4 EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, Ser/Thr (non-receptor); Protein kinase, TKL Q9NWZ3 51135 12q12 human S8-p 2859004 MNKPITPsTYVRCLN molecular association, regulation; protein conformation MYD88(INDUCES) 27876844 2 2 0 interferes with the Myddosome formation -RPS6KA6 RSK4 EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, AGC; Protein kinase, Ser/Thr (non-receptor) Q9UK32 27330 Xq21.1 human S372-p 457601 TAKTPKDsPGLPASA Pkinase_C enzymatic activity, induced 15632195 1 7 1 -NDE1 NUDE1 iso1 Cell cycle regulation; Cytoskeletal; Microtubule-binding Q9NXR1-1 54820 16p13.11 human T215-p 469489 ATGSVPStPIAHRGP NUDE_C molecular association, regulation; intracellular localization ZNF365(DISRUPTS) 16682949 1 6 6 -Cdh5 CDH5 Cell adhesion; Membrane protein, integral; Motility/polarity/chemotaxis P55284 12562 8 D3|8 53.04 cM mouse S776-p 13258704 MLAELYGsDPQEELI molecular association, regulation PAR3(INDUCES) 20047332 1 0 0 enhances PDZ-ligand interactions -PTH PTH Apoptosis; Hormone; Secreted; Secreted, signal peptide P01270 5741 11p15.3 human S34-p 23135905 SVKKRSVsEIQLMHN Parathyroid molecular association, regulation signaling pathway regulation PTHR(INDUCES) 25158085 1 1 11 -VIM Vimentin Cytoskeletal; Motility/polarity/chemotaxis P08670 7431 10p13 human S51-p 449416 LRPSTSRsLYASSPG Filament_head molecular association, regulation cytoskeletal reorganization Vimentin(DISRUPTS) 11895474 5 49 50 -Prkch PKCH EC 2.7.11.13; KINASE; Kinase, protein; Protein kinase, AGC; Protein kinase, Ser/Thr (non-receptor) P23298 18755 12|12 C3 mouse S317-p 7445167 GLQPGNIsPTSKLIS molecular association, regulation; intracellular localization CTLA-4(INDUCES) 24705298 1 12 0 -Vav1 VAV1 GEF; GEF, Rac/Rho; Motility/polarity/chemotaxis; Oncoprotein P27870 22324 17 D|17 29.76 cM mouse Y544-p 33373900 RGTFYQGyRCYRCRA C1_1 activity, induced 24736456 1 1 0 based on a lower activity of Y->F mutant in Jurkat cells stimulated by anti-CD3 antibody -FOXM1 FOXM1 DNA-binding; Transcription factor Q08050 2305 12p13.33 human K201-sm 31898500 GLGSRSIkQEMEEKE protein degradation; ubiquitination; intracellular localization cell cycle regulation; cell growth, inhibited; transcription, inhibited 24362530 2 1 0 -RBL1 Rb-like 1 Transcription, coactivator/corepressor; Tumor suppressor P28749 5933 20q11.23 human T369-p 451295 KRSFAPStPLTGRRY molecular association, regulation cell growth, altered E2F4(DISRUPTS) 11884610; 12006580 2 15 35 -IFNAR2 IFNAR2 Membrane protein, integral; Receptor, cytokine P48551 3455 21q22.11 human Y512-p 3063304 DVDLGDGyIMR____ activity, induced; molecular association, regulation; phosphorylation transcription, induced; signaling pathway regulation; transcription, altered STAT2(DISRUPTS) 11682488; 12105218; 20038197; 34813358 5 0 0 STAT phosphorylation and activation; lack of STAT1, 2, 3 phosphorylation in IFNAR2 Y337/512F mutant; induces STAT phosphorylation and signaling; IFN induced STAT activation and induced transcription -CUL3 CUL3 Cell cycle regulation; UBIQUITIN LIGASE; Ubiquitin conjugating system; Ubiquitin ligase Q13618 8452 2q36.2 human Y764-p 25180500 TPEDRKVyTYVA___ intracellular localization 22448038 1 0 0 -Snap23 SNAP23 Vesicle O09044 20619 2 60.37 cM|2 E5 mouse S95-p 455262 NRTKNFEsGKNYKAT SNAP-25 protein stabilization; molecular association, regulation exocytosis, altered; exocytosis, induced STX11(INDUCES) 18692471; 23613522; 25083866; 25176657 14 4 2 granule exocytosis (mast cell degranulation); required for IKK2-mediated mast cells degranulation; membrane fusion, SNARE complex formation, hemostasis; stabilizes SNARE complex, important for phagosomal MHC-1 accumulation and cross-presentation -Creb1 CREB iso1 DNA-binding; Transcription factor P15337-1 81646 9q32 rat S117-p 451810 DSQESVDsVTDSQKR pKID protein degradation 16782881 5 0 0 required for PDGF-induced protein ubiquitination -Rps6ka5 MSK1 EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, AGC; Protein kinase, Ser/Thr (non-receptor) Q8C050 73086 12|12 E mouse S375-p 448216 ERLFQGYsFVAPSIL Pkinase_C enzymatic activity, induced 17196532 23 19 41 -MAP1LC3B LC3B Autophagy; Microtubule-binding; Ubiquitin-like modifier; Vesicle Q9GZQ8 81631 16q24.2 human K49-ac 1881371300 KQLPVLDkTKFLVPD protein stabilization autophagy, inhibited 34590387 1 1 0 compromises LC3B lipidation in vitro and in HeLa cells, which leads to deficiency in the formation of autophagic structures and autophagic degradation -NLGN4X NLGN4X Membrane protein, integral Q8N0W4 57502 Xp22.32-p22.31 human T707-p 40245512 KDKRRHEtHRRPSPQ cell growth, induced 25675530 1 1 0 induces synaptogenesis -IGF2BP2 IGF2BP2 RNA-binding; Translation Q9Y6M1 10644 3q27.2 human K497-sm 580826994 GRIFGKLkEENFFNP protein stabilization cell growth, induced 34345216 1 1 0 promotes vasculogenic mimicry (VM) formation in glioma cells -ARRB1 ARRB1 Adaptor/scaffold P49407 408 11q13.4 human S163-p 31894300 EKIHKRNsVRLVIRK Arrestin_N activity, induced; molecular association, regulation CD3Z(INDUCES) 24502978 1 1 0 -Tp53 p53 Activator; DNA-binding; Motility/polarity/chemotaxis; Nuclear receptor co-regulator; Transcription factor; Tumor suppressor P10361 24842 10q24 rat S376-p 447534 TKKGQSTsRHKKPMI activity, induced; activity, inhibited apoptosis, inhibited 11574421; 35850611 15 2 0 Tolfenamic acid decreased the apoptotic positive cellular rate from 11.91 to 7.47%; tolfenamic acid significantly increased the phosphorylation level of p53 at the Ser378 site andreduced the acetylation level at the Lys382 site site, suggesting that tolfenamic acid may reduce the activity of p53 -FKBP5 FKBP5 Chaperone; EC 5.2.1.8; Isomerase Q13451 2289 6p21.31 human K28-ac 63115301 QGEDITSkKDRGVLK molecular association, regulation carcinogenesis, altered; apoptosis, induced PHLPP(DISRUPTS); Akt1(DISRUPTS) 28147277 1 1 0 induces Akt phosphorylation at S473 and enzymatic activation, regulates cancer cell sensitivity to genotoxic agents -PI4KB PIK4CB Carbohydrate Metabolism - inositol phosphate; EC 2.7.1.67; Kinase, lipid; Motility/polarity/chemotaxis Q9UBF8 5298 1q21.3 human S294-p 457621 SNLKRTAsNPKVENE molecular association, regulation; intracellular localization ERK1 iso3(INDUCES) 26459638; 33090289 7 38 9 regulation of myocellular glucose uptake, redulation of insulin-resistance in cardiomyocytes -ITGB4 ITGB4 Cell adhesion; Membrane protein, integral; Motility/polarity/chemotaxis; Receptor, misc. P16144 3691 17q25.1 human Y1492-p 450140 SSTLTRDyNSLTRSE molecular association, regulation Syk(INDUCES) 25531330 3 0 72 -DYRK2 DYRK2 iso2 EC 2.7.12.1; KINASE; Kinase, protein; Protein kinase, CMGC; Protein kinase, dual-specificity (non-receptor) Q92630-2 8445 12q15 human T488-p 1874397814 TESTGAItSISKLPP cell cycle regulation; apoptosis, induced 34363019 1 1 0 -SLC25A5 SLC25A5 Membrane protein, integral; Membrane protein, multi-pass; Mitochondrial; Transporter; Transporter, SLC family P05141 292 Xq24 human Y195-p 458470 RAAYFGIyDTAKGML Mito_carr; TM molecular association, regulation NCK2(NOT_REPORTED) 23322602 0 14 136 -EPS8 EPS8 Adaptor/scaffold Q12929 2059 12p12.3 human Y252-p 462061 DFEKPRQyHEQEETP molecular association, regulation IRS4(INDUCES) 23626693 1 3 3 -KRT8 K8 Cytoskeletal P05787 3856 12q13.13 human K364-sm 25027601 EAALQRAkQDMARQL Filament cytoskeletal reorganization 21062750 1 2 0 sumoylation regulate solubility; modified by poly-SUMO-2/3 chains, oxidative stress, apoptosis, and/or phosphatase inhibition increase sumoylation in primary hepatocytes; K to R mutants show filament disorganization -RAB7A Rab7 G protein; G protein, monomeric; G protein, monomeric, Rab P51149 7879 3q21.3 human K38-ub 12322359 KKFSNQYkATIGADF Ras molecular association, regulation; intracellular localization endocytosis, induced RILP(INDUCES) 26911690 1 8 5 -EIF4E EIF4E Translation; Translation initiation P06730 1977 4q23 human T210-p 450199 TATKSGStTKNRFVV cell growth, altered 15574771 3 2 0 S209A/T210A mutant showed reduced transport of cyclin D1 mRNA from nucleus to cytoplasm. eiF4E cellular distribution not affected by phosphorylation. -CHAT CHAT iso3 ACETYLTRANSFERASE; Acetyltransferase; EC 2.3.1.6; Lipid Metabolism - glycerophospholipid P28329-3 1103 10q11.23 human S347-p 454036 LKHVTQSsRKLIRAD Carn_acyltransf enzymatic activity, induced 15381704 1 0 0 -PKM PKM Carbohydrate Metabolism - glycolysis and gluconeogenesis; Carbohydrate Metabolism - pyruvate; EC 2.7.1.40; KINASE; Kinase, other; Mitochondrial; Nucleotide Metabolism - purine P14618 5315 15q23 human T365-gl 1879953201 CIMLSGEtAKGDYPL enzymatic activity, inhibited cell growth, induced PKM(DISRUPTS) 31501520 1 0 0 O-GlcNAcylation of PKM inhibits its catalytic activity and tetramerization -TSC2 TSC2 Cell cycle regulation; GAP; GAP, misc.; Nuclear receptor co-regulator; Tumor suppressor P49815 7249 16p13.3 human S1130-p 448499 GARDRVRsMSGGHGL activity, inhibited 27451907 3 16 13 cell survival induced -Trpv2 TRPV2 Channel, cation; Membrane protein, integral; Membrane protein, multi-pass Q9WUD2 29465 10q23 rat Y471-p 1877505002 WISFMDSyFEILFLL Ion_trans activity, induced; protein stabilization endocytosis, induced 35686730 1 0 0 -PDPK1 PDK1 EC 2.7.11.1; KINASE; Kinase, protein; Nuclear receptor co-regulator; Protein kinase, AGC; Protein kinase, Ser/Thr (non-receptor) O15530 5170 16p13.3 human S398-p 12729601 SSSSHSLsASDTGLP apoptosis, altered; cell growth, altered 19920149 2 0 0 -PIAS1 PIAS1 EC 6.3.2.-; Nuclear receptor co-regulator; SUMO LIGASE; SUMO conjugating system; SUMO ligase; Transcription, coactivator/corepressor O75925 8554 15q23 human R303-m2 6742810 RLRAKGIrNPDHSRA cell growth, inhibited; transcription, inhibited; signaling pathway regulation 19136629 1 1 0 negative regulation of STAT1 signaling/activation -Fbxw8 FBXW8 Cell development/differentiation; UBIQUITIN LIGASE; Ubiquitin conjugating system; Ubiquitin ligase Q8BIA4 231672 5|5 F mouse S86-p 4751099 DTSSRSRsPPDRDAT protein stabilization; intracellular localization 23142081 1 14 0 -Mob1a MOB1A Protein kinase, regulatory subunit Q921Y0 232157 6|6 C3 mouse T35-p 3212769 LLKHAEAtLGSGNLR Mob1_phocein carcinogenesis, inhibited; cell growth, inhibited 34678143 13 45 34 -Anxa2 ANXA2 Calcium-binding; Lipid-binding; Motility/polarity/chemotaxis Q07936 56611 8q24 rat Y24-p 449483 HSTPPSAyGSVKPYT ubiquitination; intracellular localization ACTB(INDUCES) 26644180 29 64 2613 nuclear pool of pTyr23AnxA2 is diminished and replaced by a cortical pool after H2O2 treatment, nuclear pTyr23AnxA2 is found in PML bodies -Ppp1r1b DARPP-32 Motility/polarity/chemotaxis; Protein phosphatase, regulatory subunit Q6J4I0 360616 10q31 rat S97-p 466340 LQTISNLsENQASEE DARPP-32 molecular association, regulation ADD2(INDUCES) 26639316 3 2 0 -STAR STAR Carrier; Lipid-binding; Mitochondrial P49675 6770 8p11.23 human S195-p 450442 RCAKRRGsTCVLAGM START activity, induced; molecular association, regulation; protein conformation 14-3-3 sigma(INDUCES); 14-3-3 epsilon(INDUCES); 14-3-3 gamma(INDUCES) 10548884; 32633081 9 1 0 -MC1R MC1R GPCR, family 1; Membrane protein, integral; Membrane protein, multi-pass; Receptor, GPCR Q01726 4157 16q24.3 human S316-p 471420 LKEVLTCsW______ receptor internalization, altered 17130136 1 0 0 T308 and S316 phosphorylation regulate MC1R internalization and desensitization. -HSPA1A HSP70 Chaperone; Heat shock protein; Motility/polarity/chemotaxis P0DMV8 3303 6p21.33 human K159-ac 31089500 DSQRQATkDAGVIAG HSP70 sumoylation autophagy, induced 23569248 1 1 0 acetylation induces sumoylation of PIK3C3 -MECOM EVI1 C2H2-type zinc finger protein; Methyltransferase, protein lysine, predicted; Oncoprotein; Transcription regulation; Transcription, coactivator/corepressor Q03112 2122 3q26.2 human S624-p 4702996 KMFKDKVsPLQNLAS molecular association, regulation; methylation transcription, altered DNMT3A(INDUCES); CTBP1(DISRUPTS) 33082307 1 13 0 induces hematopoietic-stem cell self renewal -Cacng2 Stargazin Channel, calcium; Membrane protein, integral; Membrane protein, multi-pass O88602 12300 15 E1|15 36.92 cM mouse S221-p 2047941 ATDYLQAsAITRIPS intracellular localization 20670832 1 4 0 AMPAR immobilization in synaptic membrane -Grk2 GRK2 EC 2.7.11.15; KINASE; Kinase, protein; Protein kinase, AGC; Protein kinase, Ser/Thr (non-receptor) Q99MK8 110355 19 A|19 3.98 cM mouse Y86-p 447727 AKPLVEFyEEIKKYE RGS cell motility, altered 18369319 5 0 0 -RAPH1 RAPH1 Adaptor/scaffold; Motility/polarity/chemotaxis Q70E73 65059 2q33.2 human Y510-p 477343 AKYGKQLyMNYQEAL molecular association, regulation cell motility, induced 26996666 1 0 1 Lpd-Scar/WAVE interaction is positively regulated by c-Abl and c-Src, breast cancer cell invasion -Mylk2 skMLCK EC 2.7.11.18; KINASE; Kinase, protein; Motility/polarity/chemotaxis; Protein kinase, CAMK; Protein kinase, Ser/Thr (non-receptor) P20689 117558 3q41 rat S168-p 2864200 PAFLHSPsCPAIISC molecular association, regulation 14-3-3 beta(INDUCES) 11795875 2 3 0 -MAPT Tau iso8 ACETYLTRANSFERASE; Acetyltransferase; Cytoskeletal P10636-8 4137 17q21.31 human S400-gl 18416102 VYKSPVVsGDTSPRH protein conformation; phosphorylation 34220449 3 3 0 regulates fibrillar assembly and aggregation; inhibits phosphorylation at S400 and S396 -Katna1 KATNA1 EC 3.6.4.3; Hydrolase; Motility/polarity/chemotaxis Q6E0V2 292464 rat K330-sm 1883544400 HEASRRVkAELLVQM cell growth, induced; cytoskeletal reorganization 35868557 1 1 0 K330 SUMOylation enhances hippocampal neurite outgrowth and promotes the microtubule severing activity of KATNA1. -CLSPN claspin Actin-binding; Cell cycle regulation Q9HAW4 63967 1p34.3 human T916-p 455334 DELLDLCtGKFTSQA molecular association, regulation chromatin organization, altered Chk1(INDUCES) 15707391; 16963448 3 0 0 regulates Chk1 activity in response to hydroxyurea -GCM1 GCM1 DNA-binding; Transcription factor Q9NP62 8521 6p12.1 human K406-ac 460588 QQYSLPSkSSKWDFE protein stabilization; ubiquitination transcription, induced 16166624 1 0 0 inhibits ubiquitination -FBXL20 FBXL20 UBIQUITIN LIGASE; Ubiquitin ligase Q96IG2 84961 17q12 human S425-p 4149424 PPPSVGGsRQRFCRC protein degradation; molecular association, regulation carcinogenesis, inhibited; cell growth, inhibited; apoptosis, induced FBXO31(INDUCES) 34587475 1 5 2 -PTK2 FAK EC 2.7.10.2; KINASE; Kinase, protein; Protein kinase, TK; Protein kinase, tyrosine (non-receptor) Q05397 5747 8q24.3 human Y407-p 447888 IIDEEDTyTMPSTRD enzymatic activity, induced cell motility, altered; cytoskeletal reorganization; cell adhesion, altered 15561106; 15735019; 16760434 28 13 139 -GAPDH GAPDH Carbohydrate Metabolism - glycolysis and gluconeogenesis; EC 1.2.1.12; Oxidoreductase P04406 2597 12p13.31 human K139-ub 21175144 VMGVNHEkYDNSLKI activity, induced; molecular association, regulation cell motility, induced; cell growth, induced TRAF2(INDUCES) 37450367 1 6 0 K139 ubiquitylation promotes cell proliferation and motility-migration and metastasis; K139 is critical for its binding to TRAF2 and activation of the NF-kB pathways leading to proliferation and migration -Nfya NFYA DNA-binding; Transcription factor P23708 18044 17 C|17 23.99 cM mouse K283-ac 4659500 KRRQARAkLEAEGKI CBFB_NFYA cell growth, induced; transcription, induced 18815279 1 0 0 -ITGAX ITGAX Membrane protein, integral; Motility/polarity/chemotaxis P20702 3687 16p11.2 human S1158-p 29606704 ENGTQTPsPPSEK__ activity, induced cell adhesion, induced 24129562 1 0 0 inside-out activation, phagocytosis -Pikfyve PIKFYVE Carbohydrate Metabolism - inositol phosphate; EC 2.7.1.150; KINASE; Kinase, lipid; Motility/polarity/chemotaxis; Protein kinase, Ser/Thr (non-receptor) Q9Z1T6 18711 1|1 C2 mouse S1548-p 4272931 DTSPRNIsPGLHNGE enzymatic activity, induced autophagy, induced 34107300 1 23 0 -KIF2C KIF2C Cancer Testis Antigen (CTA); Microtubule-binding; Motility/polarity/chemotaxis; Motor Q99661 11004 1p34.1 human S109-p 2132103 APKESLRsRSTRMST molecular association, regulation; intracellular localization; activity, inhibited cytoskeletal reorganization EB1(DISRUPTS) 14960279; 19632184 2 0 0 involved in microtubule tip tracking -SPSB1 SSB1 Adaptor/scaffold; Ubiquitin conjugating system Q96BD6 80176 1p36.22 human Y31-p 455116 QELQGLDyCKPTRLD molecular association, regulation RASA1(INDUCES) 15713673 1 0 0 -RBPJ RBPJ Cell development/differentiation; Transcription factor Q06330 3516 4p15.2 human T339-p 23298201 STDKAEYtFYEGMGP protein degradation; ubiquitination 22302987 1 0 0 -RGCC RGC32 iso2 Cell cycle regulation; Protein kinase, regulatory subunit Q9H4X1-2 28984 13q14.11 human T91-p 7105234 ALLSATVtPQKAKLG RGCC cell cycle regulation; cell growth, induced 35462050 2 8 1 -XRCC1 XRCC1 DNA repair, damage P18887 7515 19q13.31 human S371-p 458811 FANTPKYsQVLGLGG BRCT molecular association, regulation XRCC1(DISRUPTS) 16397295 1 0 1 -BCL2L1 Bcl-xL Apoptosis; Autophagy; Membrane protein, integral; Mitochondrial Q07817 598 20q11.21 human S62-p 449099 PSWHLADsPAVNGAT activity, induced; molecular association, regulation; intracellular localization; protein conformation cell cycle regulation; apoptosis, altered; cell growth, inhibited; apoptosis, induced BAK1(DISRUPTS); CDK1(DISRUPTS); CDK1(INDUCES); BAX(DISRUPTS) 12633850; 17369848; 18794113; 18974096; 20363734; 22617334; 24013390; 27398719; 28486788; 31367011; 34064109; 35436470 18 1 0 -Upf1 RENT1 C2H2-type zinc finger protein; EC 3.6.1.-; EC 3.6.4.-; Hydrolase; RNA-binding Q9EPU0 19704 8 B3.3|8 34.15 cM mouse S1084-p 12559503 GLSQPELsQDSYLGD molecular association, regulation STAU(INDUCES) 22503102 3 0 0 increases Stau1-mediated decay of mRNA; regulates adipogenesis -Chpt1 CHPT1 EC 2.7.8.2; Lipid Metabolism - ether lipid; Lipid Metabolism - glycerophospholipid; Membrane protein, integral; Membrane protein, multi-pass; Transferase Q8C025 212862 10|10 C1 mouse K292-ub 12718514 SATNMFEkHPCLYTL protein degradation; enzymatic activity, inhibited 20018880 1 0 0 -SH2B3 LNK Adaptor/scaffold Q9UQQ2 10019 12q24.12 human S150-p 14575499 RHIFRRRsAGELPAA molecular association, regulation signaling pathway regulation 14-3-3 zeta(INDUCES) 24704825 0 23 4 silencing of 14-3-3 enhances tumor growth in Nod-SCID mice injected with OVCAR5 cells expressing LNK -Card11 CARD11 Adaptor/scaffold Q8CIS0 108723 5|5 G2 mouse S657-p 457639 LERPFRPsVTSGGHV activity, induced; molecular association, regulation Bcl-10(INDUCES) 16356855; 19917688 6 0 0 -PSMA7 PSMA7 EC 3.4.25.1; Protease; Proteasome complex O14818 5688 20q13.33 human Y106-p 15570108 EDPVTVEyITRYIAS Proteasome protein stabilization; ubiquitination 25620702 1 2 1 -MSH2 MSH2 DNA-binding; Tumor suppressor P43246 4436 2p21-p16.3 human Y238-p 36121371 DFSTKDIyQDLNRLL MutS_II molecular association, regulation apoptosis, inhibited MSH6(DISRUPTS) 25978431 1 2 0 Enforced expression of MSH2 Y238F induces spontaneous apoptosis -CBL CBL Adaptor/scaffold; EC 6.3.2.-; EC 6.3.2.19; Ligase; Motility/polarity/chemotaxis; Oncoprotein; UBIQUITIN LIGASE; Ubiquitin conjugating system; Ubiquitin ligase P22681 867 11q23.3 human S619-p 4704596 RELTNRHsLPFSLPS molecular association, regulation 14-3-3 eta(INDUCES) 11024037 1 13 17 -FLT4 VEGFR3 EC 2.7.10.1; KINASE; Kinase, protein; Membrane protein, integral; Protein kinase, TK; Protein kinase, tyrosine (receptor) P35916 2324 5q35.3 human Y1337-p 2874406 QVFYNSEyGELSEPS molecular association, regulation; enzymatic activity, induced cell motility, induced; cell growth, induced SHC1(INDUCES); CRK(INDUCES) 16076871; 20431062 4 1 2 -ERCC6L PICH EC 3.6.4.12; Helicase Q2NKX8 54821 Xq13.1 human T1063-p 474544 VKQFDAStPKNDISP molecular association, regulation; intracellular localization BLM(INDUCES); TOP3A(INDUCES) 17218258; 36719798 2 4 4 -VIM Vimentin Cytoskeletal; Motility/polarity/chemotaxis P08670 7431 10p13 human T327-p 3180351 RRQVQSLtCEVDALK Filament carcinogenesis, induced; cell motility, induced; cell growth, induced 33963314 1 4 0 -RUFY1 RUFY1 Ubiquitin conjugating system Q96T51 80230 5q35.3 human Y400-p 451278 RQGLDEMySDVWKQL intracellular localization 11877430 1 1 23 -Esrra ERR1 DNA-binding; Nuclear receptor; Transcription regulation O08580 26379 19 A|19 5.08 cM mouse K14-sm 487493 GIEPLYIkAEPASPD transcription, inhibited 17676930; 18063693 2 1 0 -Map3k11 MLK3 EC 2.7.11.25; KINASE; Kinase, protein; Protein kinase, Ser/Thr (non-receptor); Protein kinase, TKL Q80XI6 26403 19 A|19 4.34 cM mouse S675-p 448790 LSRERGEsPTAPPPA enzymatic activity, inhibited 37085815 4 0 0 -INPP5D SHIP EC 3.1.3.86; Motility/polarity/chemotaxis; Phosphatase, lipid Q92835 3635 2q37.1 human Y865-p 454794 GKTREKLyDFVKTER molecular association, regulation SH2D1B(NOT_REPORTED) 23322602 1 25 364 -PDCD6IP Alix Adaptor/scaffold; Apoptosis Q8WUM4 10015 3p22.3 human S721-p 34504755 AREPSAPsIPTPAYQ molecular association, regulation cell cycle regulation Alix(DISRUPTS) 26859355 1 2 0 EIAV budding, cytokinetic abscission -SMC1A Smc1 DNA replication; RNA splicing Q14683 8243 Xp11.22 human S966-p 448698 GEDSVSGsQRISSIY SMC_N molecular association, regulation; intracellular localization cell cycle regulation; cytoskeletal reorganization RAE1(INDUCES) 11877376; 11877377; 18832153 20 15 67 -POLH POLH DNA repair, damage; EC 2.7.7.7; Transferase Q9Y253 5429 6p21.1 human K515-sm 1877365910 PMSNSPSkPSLPFQT intracellular localization; enzymatic activity, inhibited 32350109 1 1 0 -OPTN optineurin Inhibitor Q96CV9 10133 10p13 human S513-p 21214714 FEDGGRQsLMEMQSR ubiquitination; intracellular localization 26365381; 27035970 4 5 0 recruitment to depolarized mitochondria,TBK1 activation, mitophagy; recruitment to mitochondria -Trp53 p53 iso2 Activator; DNA-binding; Motility/polarity/chemotaxis; Nuclear receptor co-regulator; Transcription factor; Tumor suppressor Q80ZA1 22059 11 B3|11 42.83 cM mouse K317-ac 458976 SASPPQKkKPLDGEY P53_tetramer intracellular localization; protein conformation apoptosis, inhibited 22696202 56 2 0 induces localization and conformational activation of Bax -DDX5 DDX5 EC 3.6.4.13; Helicase; Nuclear receptor co-regulator; Nucleolus; RNA splicing; RNA-binding; Spliceosome P17844 1655 17q23.3 human K33-ac 466259 AGPLSGKkFGNPGEK protein stabilization; molecular association, regulation carcinogenesis, induced; transcription, induced HDAC1(INDUCES); HDAC2(INDUCES) 20663877 1 2 17 -FOXO1 FOXO1A DNA-binding; Nuclear receptor co-regulator; Oncoprotein; Transcription factor Q12778 2308 13q14.11 human T24-p 448560 LPRPRSCtWPLPRPE molecular association, regulation; intracellular localization; activity, inhibited; phosphorylation cell growth, induced; signaling pathway regulation; transcription, altered; transcription, inhibited 14-3-3 beta(INDUCES); 14-3-3 zeta(INDUCES); 14-3-3 gamma(INDUCES) DNA(DISRUPTS) 11237865; 12228231; 14664696; 15934941; 16670091; 20061393; 20519497; 22081023; 23995784; 26539823; 31308176 62 6 39 -Irak1 IRAK1 EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, Ser/Thr (non-receptor); Protein kinase, TKL B2RYH5 363520 Xq37 rat K397-ub 7452909 YLPEEYIkTGRLAVD Pkinase protein degradation 21708940 2 5 2 -PTPN22 PTPN22 EC 3.1.3.48; Motility/polarity/chemotaxis; PHOSPHATASE; Protein phosphatase, tyrosine (non-receptor) Q9Y2R2 26191 1p13.2 human S751-p 5963554 KSFTRSKsLKILRNM protein stabilization; molecular association, regulation; intracellular localization signaling pathway regulation CSK(INDUCES) 32184287 1 1 1 TCR signaling; Inhibits ubiquitination and protein degradation -Sipa1l1 SIPA1L1 GAP; GAP, Ras O35412 246212 6q24 rat T1348-p 26348504 SADSGIDtASYGLSH protein degradation; molecular association, regulation; ubiquitination BTRC(INDUCES) 18723513 1 1 0 -Mapk3 ERK1 EC 2.7.11.24; KINASE; Kinase, protein; Protein kinase, CMGC; Protein kinase, Ser/Thr (non-receptor) P21708 50689 1q36 rat T203-p 447542 HDHTGFLtEYVATRW Pkinase activity, induced; intracellular localization; enzymatic activity, induced translation, altered; cell adhesion, induced; signaling pathway regulation; cell growth, altered 10473611; 11731096; 12163549; 12595539; 14627993; 15757502; 16368189; 19427337; 19943942; 20096547; 21357465; 21738764; 21917714; 22076135; 34475824; 8387499 1343 110 2017 -PLK1 PLK1 EC 2.7.11.21; KINASE; Kinase, protein; Protein kinase, Other; Protein kinase, Ser/Thr (non-receptor) P53350 5347 16p12.2 human S137-p 448138 LELCRRRsLLELHKR Pkinase molecular association, regulation; intracellular localization; phosphorylation; enzymatic activity, induced cell cycle regulation; DNA repair, induced; cell growth, induced; apoptosis, inhibited Other(DISRUPTS) 12207013; 15713655; 19706541; 34197606 8 3 0 -Epha5 EphA5 EC 2.7.10.1; KINASE; Kinase, protein; Membrane protein, integral; Protein kinase, TK; Protein kinase, tyrosine (receptor) Q60629 13839 5 E1|5 43.0 cM mouse Y672-p 451542 EDDPEAAyTTRGGKI PK_Tyr_Ser-Thr cell cycle regulation; cell motility, altered 18515860 0 32 700 -BCL6 Bcl-6 C2H2-type zinc finger protein; Oncoprotein; Transcription factor P41182 604 3q27.3 human S333-p 447600 KGLVSPQsPQKSDCQ protein degradation 9649500 2 21 25 -FKBP5 FKBP5 Chaperone; EC 5.2.1.8; Isomerase Q13451 2289 6p21.31 human K422-sm 56400001 KFAEQDAkEEANKAM molecular association, regulation; intracellular localization transcription, inhibited; signaling pathway regulation HSP90A(INDUCES); GR(INDUCES) 27177020 1 1 0 regulation of GR and Hsp90 cochaperon activity -Bmal1 BMAL1 iso4 DNA-binding; Transcription factor Q9WTL8-4 11865 7 F1|7 59.17 cM mouse K538-ac 1968606 DASSPGGkKILNGGT activity, induced; molecular association, regulation transcription, altered CK2B(INDUCES) 26562092; 31150620 8 0 0 transcriptional oscillation, synchronization of circadian clocks in peripheral tissues ; inhibits S90 phosphorylation -Etv1 ETV1 DNA-binding; Oncoprotein; Transcription factor P41164 14009 12 A3|12 17.99 cM mouse S216-p 3059600 PMYQRQMsEPNIPFP ETS_PEA3_N activity, inhibited transcription, altered 10982847 3 3 2 in Mv1Lu cells (mutation shows no effect in HeLa cells) -ABI1 Abi-1 Adaptor/scaffold; Motility/polarity/chemotaxis Q8IZP0 10006 10p12.1 human S183-p 486178 PPTQKPPsPPMSGRG molecular association, regulation cell motility, altered; cytoskeletal reorganization 21419341 1 69 51 regulates WRC (WAVE2 regulatory complex) interaction with Arp2/3 and lamellipodial protrusion -SNCA SNCA Adaptor/scaffold P37840 6622 4q22.1 human K23-ub 466356 VAAAEKTkQGVAEAA Synuclein ubiquitination; phosphorylation 16847063 1 3 2 SNCA is phosphorylated, truncated, and then deposited to Lewy bodies.and then ubiquitinated which occurs at K12, K21. and K23 -KIZ Kizuna Cell cycle regulation Q2M2Z5 55857 20p11.23 human T379-p 469605 WSTSSDLtISISEDD cytoskeletal reorganization 16980960 1 0 0 stabilizes mitotic centrosomes -ITGA3 ITGA3 Cell adhesion; Membrane protein, integral; Motility/polarity/chemotaxis; Receptor, misc. P26006 3675 17q21.33 human S1042-p 447602 AEMKSQPsETERLTD molecular association, regulation; intracellular localization cytoskeletal reorganization; cell adhesion, altered 11179420 1 10 0 -Gabrg2 GABRG2 Channel, chloride; Channel, ligand-gated; Membrane protein, integral; Membrane protein, multi-pass; Transporter; Transporter, ion channel P22723 14406 11 A5|11 24.8 cM mouse K371-ub 11956713 PSKDKDKkKKNPLLR Neur_chan_memb protein degradation; receptor internalization, altered 19815531 1 0 0 regulation of the late endosomal/lysosomal trafficking of GABA receptors, regulation of synaptic transmission -DTD1 DTD1 DNA replication; EC 3.1.-.-; Hydrolase Q8TEA8 92675 20p11.23 human S197-p 1983955 KEDRSASsGAEGDVS molecular association, regulation cell cycle regulation; cell growth, induced MCM7(INDUCES); MCM3(DISRUPTS) 25258324 1 49 1 decreases DTD1 incorporation into HMW, supports DNA replication initiation -Ms4a2 FcER1B Membrane protein, integral; Membrane protein, multi-pass; Receptor, misc. P13386 25316 1q43 rat Y218-p 454405 KVPDDRLyEELHVYS molecular association, regulation GRB2(INDUCES); SHIP(INDUCES); Syk(INDUCES); SHC1(INDUCES); SHP-1(INDUCES) 17365510 2 1 0 SHIP binding is senstive to the presence of Syk. -CTNNB1 CTNNB1 Actin-binding; Cell adhesion; Motility/polarity/chemotaxis; Nuclear receptor co-regulator; Oncoprotein; Transcription factor P35222 1499 3p22.1 human K133-m1 1873284336 AEPSQMLkHAVVNLI molecular association, regulation; intracellular localization carcinogenesis, induced; cell growth, induced; transcription, induced; signaling pathway regulation FOXM1(INDUCES); CTNNA1(DISRUPTS) 28915556 1 1 0 WNT/Beta-Catenin/TCF pathway -Kif21a KIF21A Microtubule-binding; Motor Q9QXL2 16564 15 E3|15 45.86 cM mouse T1160-p 487344 NKARRRTtTQMELLY molecular association, regulation ANKRD15(DISRUPTS) 29158259 1 0 4 -Mapk8ip1 JIP1 Adaptor/scaffold Q9WVI9 19099 2|2 E1 mouse S417-p 458259 DNCASASsPYESAIG molecular association, regulation cell motility, induced KIF5A(INDUCES) 23897889 3 1 0 increased anterograde amyloid precursor protein (APP) transport, decreased retrograde run length -NIBAN1 NIBAN1 Unknown function Q9BZQ8 116496 1q25.3 human S602-p 467580 ASPARRAsAILPGVL apoptosis, inhibited NPM1(INDUCES) 22510990 1 41 26 FAM129 phosphorylation disrupts binding of NPM to MDM2 and promotes MDM2-p53 interaction, leading to p53 degredation. -KDR VEGFR2 EC 2.7.10.1; KINASE; Kinase, protein; Membrane protein, integral; Protein kinase, TK; Protein kinase, tyrosine (receptor) P35968 3791 4q12 human Y1175-p 447901 AQQDGKDyIVLPISE molecular association, regulation; enzymatic activity, induced; phosphorylation carcinogenesis, induced; cell growth, induced; cell motility, induced; cell motility, inhibited; transcription, altered; signaling pathway regulation; cell growth, altered PLCG1(INDUCES); NRP1(INDUCES); SHC1(INDUCES); SHC2(INDUCES); SHB(INDUCES) 10749680; 11103941; 11387210; 12214271; 14532277; 15026417; 17110601; 17303569; 21653826; 21893193; 25119572; 35081345 40 0 0 -UBTF UBF DNA-binding; Nucleolus; Transcription factor P17480 7343 17q21.31 human S412-p 472620 EKPKRPVsAMFIFSE HMG_box molecular association, regulation cell growth, induced; transcription, induced ECT2(INDUCES) 32350115 1 10 1 -CLIC5 CLIC5 Membrane protein, integral; Motility/polarity/chemotaxis Q9NZA1 53405 6p21.1 human Y33-p 3081200 EENESPHyDDVHEYL activity, induced; molecular association, regulation Fyn(INDUCES) 10930415 1 0 0 -Agtr1 AT1 GPCR, family 1; Membrane protein, integral; Membrane protein, multi-pass; Receptor, GPCR P25095 24180 17p12 rat S348-p 452093 PSDNMSSsAKKPASC activity, induced 16831865 2 0 0 -Dlg4 PSD-95 Adaptor/scaffold P31016 29495 10q24 rat S418-p 456447 LMNSSLGsGTASLRS protein conformation CRIPT(DISRUPTS) 21965656 1 11 1 Y397E mutant showed dissociation, triple mutant Y397E/S415E/S418E showed stronger dissociation -POLR1G ASE-1 Nucleolus; Transcription initiation complex O15446 10849 19q13.32 human Y80-p 11382803 LAGKRHRyRVLSSCP RNA_polI_A34 molecular association, regulation transcription, induced; transcription, altered CD3E(DISRUPTS) 10373416; 16809778 2 0 0 Y80 phosphorylation is associated with an initiation-competent Pol1B complex. -HIF1A HIF1A Autophagy; DNA-binding; Transcription factor Q16665 3091 14q23.2 human R258-m2 1881582605 KFSYCDErITELMGY carcinogenesis, induced 34753906 1 0 0 RMT3-mediated tumor angiogenesis -RGS2 RGS2 GAP; GAP, RGS P41220 5997 1q31.2 human S64-p 10772901 KPKTGKKsKQQAFIK activity, induced; molecular association, regulation; intracellular localization G-alpha i3(INDUCES) 14608379; 24777815 2 0 0 RGS2 phosphorylation increases G-alpha GTPase activity, and association with membrane fraction. ; inhibits CPA-induced hydrolysis -H2AFZ H2AZ DNA-binding Q5ZMD6 426361 chicken K4-ac 458911 ____AGGkAGKDSGK Histone chromatin organization, altered 19385636 4 14 250 K4, K7, and K11 acetylation destabilizes the nucleosome core particle (NCP) -Upf1 RENT1 C2H2-type zinc finger protein; EC 3.6.1.-; EC 3.6.4.-; Hydrolase; RNA-binding Q9EPU0 19704 8 B3.3|8 34.15 cM mouse S1102-p 456314 SQIDVALsQDSTYQG molecular association, regulation STAU(INDUCES) 22503102 5 51 45 increases Stau1-mediated decay of mRNA; regulates adipogenesis -Rorc RORC iso2 DNA-binding; Nuclear receptor; Transcription factor P51450-2 19885 3|3 F2.1 mouse K69-ub 206219716 CQHCRLQkCLALGMS zf-C4 cell differentiation, induced 28846085 1 0 0 -LCK Lck EC 2.7.10.2; KINASE; Kinase, protein; Oncoprotein; Protein kinase, TK; Protein kinase, tyrosine (non-receptor) P06239 3932 1p35.2 human Y394-p 447822 RLIEDNEyTAREGAK PK_Tyr_Ser-Thr molecular association, regulation; intracellular localization; protein conformation; enzymatic activity, induced carcinogenesis, induced; DNA repair, induced; cell growth, induced; transcription, induced; cell growth, altered Lck(INDUCES) 10962552; 11828322; 14623872; 18541536; 19776125; 20541955; 23202272; 29989005; 35638332; 36372231 62 96 2957 -Traf3ip2 TRAF3IP2 Apoptosis; UBIQUITIN LIGASE; Ubiquitin conjugating system; Ubiquitin ligase Q8N7N6 103213 10|10 B1 mouse S209-p 25687506 ERPLPLTsSCYLQDL molecular association, regulation transcription, inhibited TRAF6(DISRUPTS) 22851696 1 0 0 -Map4k1 HPK1 EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, STE; Protein kinase, Ser/Thr (non-receptor) P70218 26411 7|7 B1 mouse Y379-p 448160 LSDSDDDyDDVDIPA molecular association, regulation; enzymatic activity, induced transcription, altered SLP76(INDUCES); BLNK(INDUCES) 11487585; 11514608 2 1 0 -CLOCK CLOCK ACETYLTRANSFERASE; Acetyltransferase; DNA-binding; EC 2.3.1.48; Transcription factor O15516 9575 4q12 human S427-p 7911903 ALERFDHsPTPSASS protein degradation transcription, altered 19946213 2 9 0 -MRE11 MRE11A Cell cycle regulation; DNA repair, damage; DNA-binding; Deoxyribonuclease P49959 4361 11q21 human R592-me 2344810 ASRGGSQrGRADTGL intracellular localization 15970667 1 0 0 localizes in nucleus and associates with nuclear bodies and sites of DNA damage -KDM1A LSD1 DEMETHYLASE; Demethylase; EC 1.-.-.-; Nuclear receptor co-regulator; Oxidoreductase; Transcription factor O60341 23028 1p36.12 human K226-ub 1881258601 QLWLDNPkIQLTFEA protein degradation; molecular association, regulation carcinogenesis, induced; transcription, altered RCOR1(DISRUPTS); CDC6(INDUCES) 34050636 1 1 0 disrupts LSD1 association from RCOR1/HDACs complex -XRCC5 Ku80 DNA-binding; EC 3.6.1.-; EC 3.6.4.-; Helicase; Nuclear receptor co-regulator; Nucleolus; RNA-binding P13010 7520 2q35 human K525-ub 12348116 PPAEVTTkSQIPLSK Ku_C molecular association, regulation DNA repair, induced DNA(DISRUPTS) 27895153 1 4 5 -Map2 MAP2 iso3 Cytoskeletal; Motility/polarity/chemotaxis P15146-3 25595 9q32 rat T259-p 450181 YSSRTPGtPGTPSYP cytoskeletal reorganization 10826493 3 21 7 caused decrease in microtubule bundles -GPHN gephyrin Adaptor/scaffold; EC 2.10.1.1; EC 2.7.7.75 Q9NQX3 10243 14q23.3-q24.1 human C284-pa 34668144 SRLSTAScPTPKVQS molecular association, regulation; intracellular localization 25025157 1 1 0 clustering in neurons -H4C1 H4 DNA-binding P62805 8359 6p22.2 human K20-m1 1458623 GGAKRHRkVLRDNIQ CENP-T_C molecular association, regulation; acetylation; intracellular localization cell cycle regulation; DNA repair, induced; transcription, induced LUZP5(INDUCES); 53BP1(DISRUPTS); MBTD1(INDUCES); NCAPD3(INDUCES); JMJD2A(INDUCES) DNA(INDUCES) 17967882; 18470998; 19706462; 20622854; 20657587; 27153538; 33398850; 33710666 30 15 7 increased lipid accumulation, activity of KMT5A and K20 methylation, in human and in rat placenta; RNF8 recruits KMT5A to sites of DNA damage and cell survival with increase in H4K20 mono-methylation. ; MBTD1 can displace 53BP1 from the H4K20me2 histone mark -FNIP1 FNIP1 Q8TF40 96459 5q31.1 human S948-p 4734337 SALGDSEsEDTGHDM protein stabilization; molecular association, regulation signaling pathway regulation HSP90A(INDUCES) DNA(INDUCES) 30699359 1 3 0 -NDE1 NUDE1 iso1 Cell cycle regulation; Cytoskeletal; Microtubule-binding Q9NXR1-1 54820 16p13.11 human T246-p 467025 STGGTPLtPAARISA NUDE_C molecular association, regulation; intracellular localization cell cycle regulation ZNF365(DISRUPTS) 16682949; 21529751 2 14 31 -RCAN1 RCAN1 Inhibitor P53805 1827 21q22.12 human S163-p 456022 PDKQFLIsPPASPPV Calcipressin activity, induced; protein degradation transcription, altered 12809556; 16126726 7 34 5 increases calcineurin-inhibiting activity of DSCR1; Phosphorylation of MCIP at S108/S112 by MEKK3 is required for activation of calcineurin/NFAT signaling. -PELI1 PELI1 Adaptor/scaffold; EC 6.3.2.-; EC 6.3.2.19; Ligase; UBIQUITIN LIGASE; Ubiquitin conjugating system; Ubiquitin ligase Q96FA3 57162 2p14 human S82-p 7388012 HSISYTLsRAQTVVV Pellino ubiquitination; enzymatic activity, induced 19264966 2 0 0 -Ass1 ASS1 Amino Acid Metabolism - alanine, aspartate and glutamate; Amino Acid Metabolism - arginine and proline; EC 6.3.4.5; Endoplasmic reticulum; Ligase; Mitochondrial P16460 11898 2 B|2 21.81 cM mouse Y87-p 4273690 SALYEDRyLLGTSLA Arginosuc_synth enzymatic activity, induced transcription, induced; signaling pathway regulation 35016033 1 3 1 regulates JAK2-STAT1 signaling -ELF1 Elf-1 DNA-binding; Transcription factor P32519 1997 13q14.11 human T231-p 4825111 CPKYIKWtQREKGIF Ets transcription, altered 18714041 1 1 0 -HOXB7 HOXB7 DNA-binding; Motility/polarity/chemotaxis; Transcription factor P09629 3217 17q21.32 human S132-p 465569 RIYPWMRsSGTDRKR cell differentiation, altered 11290787 1 0 0 -Optn optineurin Inhibitor Q8K3K8 71648 2 A1|2 3.15 cM mouse S187-p 4762451 SGGSSEDsFVEIRMT autophagy, induced 33931895 10 30 1 regulates mitochondrial homeostasis and pluripotency -RUNX2 AML3 DNA-binding; Transcription factor Q13950 860 6p21.1 human S347-p 7386100 SDDDTATsDFCLWPS cell differentiation, inhibited; transcription, inhibited; transcription, altered 19264160; 30910359 2 2 0 in C2C12 cells -MKNK2 Mnk2 EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, CAMK; Protein kinase, Ser/Thr (non-receptor); Translation Q9HBH9 2872 19p13.3 human S437-p 456330 TSRCLQLsPPSQSKL activity, induced 23831578 2 10 3 -Ccdc88a girdin Actin-binding Q5SNZ0 108686 11|11 A3.3 mouse Y1801-p 450762 QSKDSNPyATLPRAS intracellular localization apoptosis, inhibited 28375676 5 13 137 -PXN PXN Adaptor/scaffold; Cell adhesion; Cytoskeletal; Motility/polarity/chemotaxis P49024 395832 chicken S481-p 448767 FTPFINGsFFEHDGQ LIM intracellular localization cell adhesion, altered 9658172 1 0 0 -NKX3-1 NKX3-1 DNA-binding; Transcription factor; Tumor suppressor Q99801 4824 8p21.2 human S185-p 4825101 KTKRKQLsSELGDLE protein degradation; protein stabilization; ubiquitination carcinogenesis, induced; cell growth, induced 18757402; 23129228; 25777618; 31213464 5 3 0 -TP63 p63 DNA-binding; Transcription factor Q9H3D4 8626 3q28 human T491-p 4668106 PQQRNALtPTTIPDG protein degradation DNA repair, induced; apoptosis, induced; transcription, inhibited 18769144; 19282665; 21602882 3 1 0 -DAB1 DAB1 Adaptor/scaffold Q8JH94 374083 chicken Y200-p 447960 VEDPVYQyIVFEAGH phosphorylation cytoskeletal reorganization 15057276 5 0 0 increases Src activation and overall tyrosine phosphorylation levels in the cell, alters cellular morphology -ELK1 ELK1 DNA-binding; Transcription factor P19419 2002 Xp11.23 human K254-sm 3982501 EVKVEGPkEELEVAG sumoylation; intracellular localization cell differentiation, inhibited; transcription, induced 15210726; 30789974 3 1 0 Both ELK1 and ELK-3R promote transcription, K230R, K249R, K254R does not prevent ELK1 SUMOylation, ELK1 and ELK1-3R show same intracellular localization ; regulates kinetics of nuclear export -HAT1 HAT1 ACETYLTRANSFERASE; Acetyltransferase; EC 2.3.1.48 O14929 8520 2q31.1 human S190-p 63080404 MWFIETAsFIDVDDE activity, induced; molecular association, regulation RBBP7(INDUCES) 28143904 1 0 0 -FLCN FLCN Tumor suppressor Q8NFG4 201163 17p11.2 human S73-p 3206877 GASVESSsPGPKKSD protein degradation; intracellular localization; activity, inhibited; phosphorylation cell cycle regulation; carcinogenesis, induced; signaling pathway regulation 23874397; 31395606 2 13 3 induces localization of mTORC1, increases phosphorylation of mTORC1 targets, regulates mTORC1 pathway -Wnk4 WNK4 EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, Other; Protein kinase, Ser/Thr (non-receptor) Q80UE6 69847 11|11 D mouse K447-ub 40323315 AEEDDGEkPGLKLWL protein degradation 23576762 1 1 0 regulates electrolyte homeostasis and involved in Pseudohypoaldosteronism type II (PHAII) pathogenesis -FUS hnRNP P2 DNA-binding; Nuclear receptor co-regulator; Oncoprotein; RNA splicing; RNA-binding; SUMO LIGASE P35637 2521 16p11.2 human S273-p 23113764 GGPRDQGsRHDSEQD molecular association, regulation hnRNP P2(DISRUPTS) 35753345 1 2 1 -NCOA2 SRC-2 Motility/polarity/chemotaxis; Nuclear receptor co-regulator; Transcription, coactivator/corepressor Q15596 10499 8q13.3 human S736-p 465446 TIKQEPVsPKKKENA DUF4927 transcription, induced 11301320 4 20 10 important for EGF-induced transcriptional activation -CREB1 CREB DNA-binding; Transcription factor P16220 1385 2q33.3 human K290-sm 12063904 ARECRRKkKEYVKCL bZIP_1 protein stabilization; intracellular localization transcription, induced 12552083 2 0 0 -Atf2 ATF-2 ACETYLTRANSFERASE; C2H2-type zinc finger protein; EC 2.3.1.48; Transcription factor P16951 11909 2|2 C3 mouse T51-p 448224 SVIVADQtPTPTRFL protein stabilization carcinogenesis, induced; cell growth, induced; transcription, altered 10521481; 21706057 32 57 50 -ANXA2 ANXA2 Calcium-binding; Lipid-binding; Motility/polarity/chemotaxis P04272 282689 cow S26-p 450879 TPPSAYGsVKAYTNF sumoylation; molecular association, regulation; ubiquitination; intracellular localization; protein conformation ACTG1(INDUCES); ACTB(INDUCES) RNA(INDUCES) 24780253; 28174683 14 29 100 -SOCS1 SOCS1 Inhibitor; UBIQUITIN LIGASE O15524 8651 16p13.13 human Y80-p 1868450203 LLDACGFyWGPLSVH SH2 molecular association, regulation; intracellular localization; activity, inhibited carcinogenesis, induced; signaling pathway regulation SOCS1(INDUCES); p53(DISRUPTS) 31101761 1 1 0 inactivates SOCS1-p53 senescence pathway; inhibits SOCS1 tumor suppressor activity; induces dimers formation -Shtn1 SHOT1 Unknown function Q8K2Q9 71653 19|19 D2-D3 mouse S101-p 4761847 NKTLKRIsMLYMAKL molecular association, regulation neural plasticity; cell adhesion, induced; cytoskeletal reorganization CDH2(INDUCES); Cortactin(INDUCES); NCAM-L1(INDUCES) 34010643 4 5 0 -STK11 LKB1 Autophagy; EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, CAMK; Protein kinase, Ser/Thr (non-receptor); Tumor suppressor Q15831 6794 19p13.3 human T189-p 448149 LLLTTGGtLKISDLG Pkinase apoptosis, inhibited 11430832 2 0 0 -HAX1 HAX1 Apoptosis; Endoplasmic reticulum; Mitochondrial; Vesicle O00165 10456 1q21.3 human S210-p 37043700 QPKSYFKsISVTKIT protein degradation; molecular association, regulation; ubiquitination apoptosis, induced FBXO25(INDUCES) 25419709 1 0 0 -INSIG1 INSIG1 Membrane protein, integral; Membrane protein, multi-pass O15503 3638 7q36.3 human T222-p 1868139204 ITIAFLAtLITQFLV INSIG; TM activity, induced; protein stabilization; molecular association, regulation AMFR(DISRUPTS) 30733434 1 1 0 inhibits SREBP-1c cleavage processing and lipogenic gene expression -PPP1R16B PPP1R16B Motility/polarity/chemotaxis; Protein phosphatase, regulatory subunit Q95N27 282091 cow S333-p 486244 LRHKSSLsRRTSSAG cytoskeletal reorganization 17609201 2 1 0 -Grin1 NMDAR1 Channel, calcium; Channel, ligand-gated; Membrane protein, integral; Membrane protein, multi-pass P35439 24408 3p13 rat S890-p 447737 ITSTLASsFKRRRSS molecular association, regulation; intracellular localization; activity, inhibited Calmodulin(DISRUPTS) 21163614; 9030583; 9252405 12 2 3 -SLC3A2 SLC3A2 Membrane protein, integral; Transporter P08195 6520 11q12.3 human S531-p 6003501 RRLSDQRsKERSLLH cell adhesion, altered 19065266 1 0 0 enhances cell- cell interactions -Oprm1 MOR-1 GPCR, family 1; Membrane protein, integral; Membrane protein, multi-pass; Receptor, GPCR P33535 25601 1q11 rat S375-p 447784 QNTREHPsTANTVDR molecular association, regulation; receptor desensitization, altered; receptor internalization, altered; protein conformation ARR3(INDUCES); ARRB2(INDUCES) 11278523; 12860981; 15272312; 15890842; 18558479; 23106126 24 5 0 -Zfpm2 FOG2 C2H2-type zinc finger protein; Nuclear receptor co-regulator Q8CCH7 22762 15 B3.1|15 15.74 cM mouse K471-sm 1873213001 NFSYTKIkSEPSSPR molecular association, regulation transcription, induced GATA4(DISRUPTS) 23226341 1 0 0 desumoylation induces repression -SYK Syk EC 2.7.10.2; KINASE; Kinase, protein; Protein kinase, TK; Protein kinase, tyrosine (non-receptor) P43405 6850 9q22.2 human S178-p 25687503 GKISREEsEQIVLIG SH2 cell adhesion, induced; signaling pathway regulation 22848421 1 0 0 PKC-LKB1-AMPK signaling pathway to induce cell adhesion -Parp1 PARP1 iso3 DNA repair, damage; EC 2.4.2.30; Nuclear envelope; Nuclear receptor co-regulator; Nucleolus; Transferase Q3TF18 11545 1 H4|1 84.44 cM mouse Y829-p 1869121001 HATTHNAyDLEVIDI PARP activity, induced transcription, induced; signaling pathway regulation 31399520 1 0 0 regulates LPS-induced inflammation; PARP1-NFKB pathway regulation -E2F4 E2F4 DNA-binding Q16254 1874 16q22.1 human S244-p 28843800 QEASRPNsPQLTPTA intracellular localization cell cycle regulation; transcription, induced 23919615 1 1 0 -MFN1 MFN1 EC 3.6.5.-; Hydrolase; Membrane protein, integral; Membrane protein, multi-pass; Mitochondrial Q8IWA4 55669 3q26.33 human S86-p 1498941800 AFFGRTSsGKSSVIN Dynamin_N enzymatic activity, inhibited apoptosis, induced 30659190 1 1 0 -CNN1 calponin 1 Actin-binding; Contractile; Motility/polarity/chemotaxis; Myosin-binding P26932 396522 chicken T180-p 469594 FASQQGMtAYGTRRH Calponin molecular association, regulation ACTA1(DISRUPTS) 10873572 1 0 1 f-actin (rabbit skeletal muscle) shown by co-sedimentation -NEDD8 NEDD8 Ubiquitin-like modifier Q15843 4738 14q12 human S65-p 4705608 DYKILGGsVLHLVLA ubiquitin molecular association, regulation; protein conformation PARK2(INDUCES); HSP70(INDUCES) 34642328 1 5 1 induces phosphorylation, activation and autoubiquitylation of Parkin -CBX3 CBX3 DNA-binding Q13185 11335 7p15.2 human S93-p 457001 KDGTKRKsLSDSESD molecular association, regulation; intracellular localization chromatin organization, altered; transcription, induced; signaling pathway regulation Ku70(NOT_REPORTED) 16531993; 17242207; 25216677 5 57 61 MAPK pathway -PDE5A PDE5A EC 3.1.4.35; Nucleotide Metabolism - purine; Phosphodiesterase O76074 8654 4q26 human S102-p 448178 GTPTRKIsASEFDRP molecular association, regulation; enzymatic activity, inhibited; protein conformation; enzymatic activity, induced Other(INDUCES) 16690614; 25247292 8 6 0 -Rho Rhodopsin GPCR, family 1; Membrane protein, integral; Membrane protein, multi-pass; Receptor, GPCR P15409 212541 6 E3|6 53.72 cM mouse S338-p 448679 DDASATAsKTETSQV receptor inactivation, altered 11086991 8 7 0 Mutant rhodopsins had prolonged rate of recovery with increasing number of phosphorylation sites. -RPS6KB1 p70S6K iso2 EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, AGC; Protein kinase, Ser/Thr (non-receptor); Translation P23443-2 6198 17q23.1 human K493-ac 14790001 QAFPMISkRPEHLRM molecular association, regulation; enzymatic activity, inhibited; phosphorylation transcription, inhibited Raptor(DISRUPTS) 24652283; 31028173 4 1 0 inhibits mesangial cell hypertrophy and expression of fibronectin and collagen I ; Sirt1,2 deacetylate p70S6K which enhances T389 phosphorylation and it's kinase activity -AMOT AMOT Q4VCS5 154796 Xq23 human K496-ub 41481888 LEKAMRNkLEGEIRR protein degradation 27462448 1 3 0 -TFEB TFEB DNA-binding; Transcription factor P19484 7942 6p21.1 human S142-p 3181628 AGNSAPNsPMAMLHI MITF_TFEB_C_3_N protein degradation; molecular association, regulation; ubiquitination; intracellular localization; activity, inhibited carcinogenesis, induced; autophagy, inhibited; transcription, inhibited Exportin-1(INDUCES); CHIP(INDUCES) 28754656; 32662822; 33753903; 34611296; 36970883 13 12 0 -STXBP2 STXBP2 Q15833 6813 19p13.2 human T572-p 487544 IGSSHILtPTRFLDD Sec1 molecular association, regulation; protein conformation exocytosis, induced STX3(DISRUPTS); SNAP-25(INDUCES) 17716669 1 0 0 in vitro -NHE-3 NHE3 Membrane protein, integral; Membrane protein, multi-pass; Transporter; Transporter, SLC family P26432 100009430 rabbit S515-p 31839901 NFDRRFLsKLLMRQS activity, induced; molecular association, regulation; intracellular localization Ezrin(INDUCES) 24398676 1 0 0 -BLM BLM DNA repair, damage; DNA replication; EC 3.6.4.12; Helicase P54132 641 15q26.1 human S338-p 4700251 KEDVLSTsKDLLSKP BLM_N protein stabilization; molecular association, regulation cell cycle regulation; DNA repair, altered TOPBP1(DISRUPTS) 24239288 2 7 0 -PLN PLB Inhibitor; Membrane protein, integral P61015 rabbit T17-p 448115 SAIRRAStIEMPQQA Phospholamban activity, induced 21555709 75 12 63 induces SERCA2 activity -SP1 SP1 C2H2-type zinc finger protein; DNA-binding; Transcription factor P08047 6667 12q13.13 human S728-p 2535904 VGTLPLDsGAGSEGS protein degradation; molecular association, regulation; ubiquitination signaling pathway regulation BTRC(INDUCES) 18239466; 19372209; 30181396 3 0 0 also inhibits stabilization of B-Catennin thus regulating Wnt signaling -IRF5 IRF5 DNA-binding; Transcription factor Q13568 3663 7q32.1 human S446-p 26389901 DSIRLQIsNPDLKDR protein stabilization; molecular association, regulation; intracellular localization apoptosis, induced; transcription, induced CBP(INDUCES) 18836453; 22412986; 25326418 3 2 0 -Gad2 GAD2 Amino Acid Metabolism - alanine, aspartate and glutamate; Carbohydrate Metabolism - butanoate; EC 4.1.1.15; Lyase; Other Amino Acids Metabolism - beta-alanine; Other Amino Acids Metabolism - taurine and hypotaurine Q05683 24380 17q12.3 rat T95-p 53356800 NYALLHAtDLLPACE activity, induced 26780456 1 1 0 -Mapk7 ERK5 EC 2.7.11.24; KINASE; Kinase, protein; Protein kinase, CMGC; Protein kinase, Ser/Thr (non-receptor) Q9WVS8 23939 11|11 B2 mouse T723-p 455520 LPPVFSGtPKGSGAG transcription, altered 17928297 7 13 1 -F2RL1 F2RL1 GPCR, family 1; Membrane protein, integral; Membrane protein, multi-pass; Receptor, GPCR P55085 2150 5q13.3 human S385-p 12184119 KHSRKSSsYSSSSTT receptor desensitization, induced; molecular association, regulation; phosphorylation signaling pathway regulation ARRB1(INDUCES); ARRB2(INDUCES) 33073187 1 1 1 inhibits ERK phosphorylation and signaling; regulates calcium signaling -Vasp VASP Cytoskeletal; Motility/polarity/chemotaxis B5DEX4 361517 1q21 rat S236-p 448380 GAKLRKVsKEEASGG cell adhesion, inhibited; signaling pathway regulation 33772737; 34475824 62 26 3 -NFATC4 NFAT3 DNA-binding; Transcription factor Q14934 4776 14q12 human S676-p 455348 SNGRRKRsPTQSFRF RHD_dimer activity, induced transcription, induced 15657420 2 0 0 -GTF2F1 GTF2F1 EC 2.7.11.1; KINASE; Kinase, protein; Transcription initiation complex P35269 2962 19p13.3 human T389-p 483595 RGNSRPGtPSAEGGS TFIIF_alpha activity, inhibited transcription, inhibited 10428810 1 54 270 slows down RNA pol II elongation -PTPN6 SHP-1 EC 3.1.3.48; Motility/polarity/chemotaxis; PHOSPHATASE; Protein phosphatase, tyrosine (non-receptor) P29350 5777 12p13.31 human Y276-p 15428268 ENKGKNRyKNILPFD Y_phosphatase molecular association, regulation transcription, inhibited; signaling pathway regulation GRB2(INDUCES) 14551136 1 3 50 recruitment of Grb2 targets SOCS-1 to Jak2 -Sirt7 SIRT7 DEACETYLASE; Deacetylase; EC 3.5.1.-; Nucleolus Q8BKJ9 209011 11|11 E2 mouse S260-p 1874512904 EAATEAAsKADTILC SIR2 protein stabilization; molecular association, regulation; ubiquitination; phosphorylation carcinogenesis, inhibited; cell motility, inhibited; transcription, inhibited; signaling pathway regulation UBR5(DISRUPTS); SKP2(INDUCES) 34433808 1 0 0 inhibits ubiquitination of itself, inhibits AKT phosphorylation and PI3K/AKT pathway -GRB7 GRB7 Adaptor/scaffold; Motility/polarity/chemotaxis Q14451 2886 17q12 human Y338-p 7965101 AAFRLFKyGVQLYKN PH phosphorylation cell cycle regulation; cell motility, altered 19473962 1 0 0 double mutation Grb7 Y188, 338F inhibits phosphorylation of FAK Y397 (Y428 in mouse), Y861 (Y899 in mouse) and PXN Y118; involed in tumorigenesis process -Pml PML Nucleolus; Oncoprotein; SUMO LIGASE; SUMO conjugating system; SUMO ligase; Transcription factor; Tumor suppressor; Ubiquitin conjugating system Q60953 18854 9 B|9 31.63 cM mouse K497-ac 4659502 SHEDCSRkIIKMEST DUF3583 intracellular localization transcription, induced 22274616 2 0 1 regulates PER2 nuclear localization and increases BMAL1/CLOCK transcription activity -Cdh1 CDH1 Cell adhesion; Membrane protein, integral; Motility/polarity/chemotaxis; UBIQUITIN LIGASE; Ubiquitin ligase P09803 12550 8 D3|8 53.18 cM mouse Y756-p 456025 DTRDNVYyYDEEGGG molecular association, regulation CBLL1(INDUCES) 11836526 3 2 44 -NFKB1 NFkB-p105 DNA-binding; Transcription factor P19838 4790 4q24 human S927-p 447770 DSDSVCDsGVETSFR protein degradation; ubiquitination; protein processing 10469655; 11158290; 11297557; 11976329; 12482991; 19250910 6 0 2 Ubiquitination does not require generation of polyubiquitin chains, S927A mutant can be ubiquinated and processed to p50 in vitro and can only be processed constitutively in a basal manner. -MRPL10 MRPL10 Mitochondrial; Ribosomal; Translation Q3MHY7 515014 cow K162-ac 12674401 VSEEPKVkEMVRILK Ribosomal_L10 translation, induced 20042612 1 1 0 downregulates protein synthesis -Neurog3 neurogenin 3 Cell development/differentiation; DNA-binding; Transcription factor P70661 11925 10|10 B4 mouse S183-p 35527103 VSQAGNLsPTASLEE protein degradation; molecular association, regulation; ubiquitination FBXW7(INDUCES) 25105579 2 0 0 -NFE2L2 NRF2 DNA-binding; Transcription factor Q16236 4780 2q31.2 human K538-ac 7106320 HLKDEKEkLLKEKGE bZIP_Maf molecular association, regulation transcription, induced DNA(INDUCES) 19273602 1 1 0 -RPTOR Raptor Adaptor/scaffold Q8N122 57521 17q25.3 human S855-p 3205935 QRVLDTSsLTQSAPA molecular association, regulation signaling pathway regulation 4E-BP1(DISRUPTS) 21460630 2 4 0 mTORC1 signaling -VASP VASP Cytoskeletal; Motility/polarity/chemotaxis P50552 7408 19q13.32 human S239-p 448380 GAKLRKVsKQEEASG molecular association, regulation; intracellular localization; activity, inhibited; enzymatic activity, induced carcinogenesis, inhibited; cell motility, altered; cell motility, inhibited; cell adhesion, altered; cytoskeletal reorganization; transcription, inhibited; cell growth, altered MYO1C(DISRUPTS); ACTR3B(DISRUPTS); MYO5A(DISRUPTS); Arp3(DISRUPTS); MYO1B(DISRUPTS); ARP2(DISRUPTS); ACTG1(DISRUPTS) 14679200; 15178555; 17684063; 18637808; 19798690; 20463151; 20483741; 32209483; 37019383; 37335130 62 26 3 -NUP98 NUP98 iso2 Motility/polarity/chemotaxis; Nucleoporin P52948-2 4928 11p15.4 human S664-p 14577176 AGNKHSNsNSVDDTI intracellular localization 21335236 1 15 0 as multiple sites (13PM) mutant -HDAC1 HDAC1 DEACETYLASE; Deacetylase; EC 3.5.1.98; Hydrolase; Nuclear receptor co-regulator Q13547 3065 1p35.2-p35.1 human K432-ac 4219803 EEGEGGRkNSSNFKK enzymatic activity, inhibited transcription, inhibited 16762839 2 0 0 -Tp53 p53 Activator; DNA-binding; Motility/polarity/chemotaxis; Nuclear receptor co-regulator; Transcription factor; Tumor suppressor P02340 22059 11 B3|11 42.83 cM mouse K383-ub 464662 RHKKTMVkKVGPDSD transcription, altered 15964796 10 0 1 p53K6R (K378/383/369/379/367/370/R) mutant is still ubiquitinated and shows normal stability of p53 before and after DNA damage -GJA1 GJA1 Channel, misc.; Membrane protein, integral; Membrane protein, multi-pass; Motility/polarity/chemotaxis P17302 2697 6q22.31 human S330-p 449994 AGSTISNsHAQPFDF Connexin43 protein conformation 23828237 10 14 0 -MAP3K5 ASK1 EC 2.7.11.25; KINASE; Kinase, protein; Protein kinase, STE; Protein kinase, Ser/Thr (non-receptor) Q99683 4217 6q23.3 human K1083-sm 12004431 GAEEPKLkWEHITTL HisK-N-like molecular association, regulation apoptosis, inhibited ASK1(DISRUPTS); SUMO1(INDUCES) 16142216 1 0 0 ASK1 is not sumoylated but SUMO1 interaction inhibits the oligomerization of ASK1 -Tdg TDG DNA repair, damage; EC 3.2.2.29; Hydrolase; Nuclear receptor co-regulator P56581 21665 10 C1|10 39.72 cM mouse K341-sm 3144814 DAKKMAVkEEKYDPG molecular association, regulation; intracellular localization CBP(DISRUPTS) 17060459 5 3 0 negatively regulates POD translocation ; blocks interaction with CBP preventing TDG acetylation -SLC4A4 SLC4A4 Membrane protein, integral; Membrane protein, multi-pass; Transporter; Transporter, SLC family Q9Y6R1 8671 4q13.3 human S65-p 4699735 ERISENYsDKSDIEN intracellular localization 23431199 2 18 0 reduction of surface expression; inhibition by STLK3 -Lats1 LATS1 EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, AGC; Protein kinase, Ser/Thr (non-receptor); Tumor suppressor Q8BYR2 16798 10|10 A1 mouse S908-p 457594 HQRCLAHsLVGTPNY Pkinase intracellular localization; phosphorylation; enzymatic activity, induced cell growth, inhibited; transcription, induced; signaling pathway regulation 35394840 32 5 15 -Cad CAD Amino Acid Metabolism - alanine, aspartate and glutamate; EC 2.1.3.2; EC 3.5.2.3; EC 6.3.5.5; Hydrolase; KINASE; Ligase; Nucleotide Metabolism - pyrimidine; Transferase P08955 101843763 hamster T1037-p 2861417 QQCRVLGtSPEAIDS enzymatic activity, induced 11986331 1 0 0 -ALDH2 ALDH2 Amino Acid Metabolism - arginine and proline; Amino Acid Metabolism - histidine; Amino Acid Metabolism - lysine degradation; Amino Acid Metabolism - tryptophan; Amino Acid Metabolism - valine, leucine and isoleucine degradation; Carbohydrate Metabolism - ascorbate and aldarate; Carbohydrate Metabolism - butanoate; Carbohydrate Metabolism - glycolysis and gluconeogenesis; Carbohydrate Metabolism - propanoate; Carbohydrate Metabolism - pyruvate; EC 1.2.1.3; Lipid Metabolism - fatty acid; Lipid Metabolism - glycerolipid; Mitochondrial; Other Amino Acids Metabolism - beta-alanine; Oxidoreductase; Secondary Metabolites Metabolism - limonene and pinene degradation P05091 217 12q24.12 human T356-p 1273608200 GNPFDSKtEQGPQVD Aldedh intracellular localization transcription, inhibited 30375985 0 1 0 nuclear localization , ATP6V0E2 transcription decreased, regulates foam cell formation -EIF2AK2 PKR EC 2.7.10.2; EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, Other; Protein kinase, Ser/Thr (non-receptor); Protein kinase, tyrosine (non-receptor); Translation P19525 5610 2p22.2 human S6-p 23132463 __MAGDLsAGFFMEE molecular association, regulation; enzymatic activity, inhibited; protein conformation; phosphorylation apoptosis, inhibited PKR(INDUCES) RNA(INDUCES) 33911136 1 1 1 inhibits phosphorylation at other sites and of elF2 -SUPT5H SPT5 RNA-binding; Transcription, coactivator/corepressor O00267 6829 19q13.2 human T814-p 458820 PLHDGSRtPAQSGAW transcription, altered 16427012 1 1 7 required for c-fos induction and activation in vivo -TTK TTK Cancer Testis Antigen (CTA); EC 2.7.12.1; KINASE; Kinase, protein; Protein kinase, Other; Protein kinase, dual-specificity (non-receptor) P33981 7272 6q14.1 human S214-p 14161585 TVLTAQEsFSGSLGH intracellular localization; enzymatic activity, induced 26119734 1 2 2 regulates spindle assembly checkpoint and recruitment of SAC proteins -H2ax H2AX DNA repair, damage; DNA-binding; Helicase D3ZXP3 500987 8q22 rat S139-p 448841 GKKASQAsQEY____ DNA repair, induced 33737606 289 32 29 -Bmf BMF Apoptosis; Cytoskeletal Q91ZE9 171543 2|2 E5 mouse T72-p 1874396402 QEDKATQtLSPASPS BMF molecular association, regulation; intracellular localization apoptosis, induced STARD13(DISRUPTS) 34462553 1 0 0 -GALNT2 GALNT2 EC 2.4.1.41; Glycan Metabolism - O-glycan biosynthesis; Membrane protein, integral; Transferase Q10471 2590 1q42.13 human K521-ac 25336507 RENDSRQkWEQIEGN Ricin_B_lectin molecular association, regulation; O-GalNAc glycosylation; protein conformation MUC1(DISRUPTS); MUC2(DISRUPTS) Other(INDUCES) 21651894; 23096348 1 1 0 induces binding to glycan; enhances carbohydrate specificity, decreases glycosylation -ACBD4 ACBD4 Lipid-binding Q8NC06 79777 17q21.31 human S171-p 34506016 PPSPESHsPRDLDSE molecular association, regulation VAPB(INDUCES) 35019937 1 2 0 -PTBP2 PTBP2 RNA processing; RNA-binding Q9UKA9 58155 1p21.3 human K137-sm 31089521 YSNHKELkTDNTLNQ intracellular localization 24286314 1 0 0 Decreased sumoylation causes export to cytoplasm in glioma cells. -Rela NFkB-p65 DNA-binding; Nuclear receptor co-regulator; Transcription factor Q7TQN4 309165 1q43 rat R30-m2 1881937800 IIEQPKQrGMRFRYK cell adhesion, induced; transcription, induced 35379776 1 0 0 VCAM-1 expression in VSMC, H2O2 production in VSMC treated with TMAO, vascular in?ammation in vivo -PTGS2 COX-2 EC 1.14.99.1; Lipid Metabolism - arachidonic acid; Oxidoreductase P35354 5743 1q31.1 human S601-p 1869465800 TVLLKERsTEL____ protein degradation; molecular association, regulation; intracellular localization signaling pathway regulation NLRP3(DISRUPTS); DERL1(INDUCES) 31612242 1 0 0 -SOX6 SOX6 DNA-binding P35712 55553 11p15.2 human K404-sm 2407406 TVSPTGIkNEKRGTS intracellular localization transcription, inhibited 16442531 1 0 0 -Echs1 ECHS1 Amino Acid Metabolism - lysine degradation; Amino Acid Metabolism - tryptophan; Amino Acid Metabolism - valine, leucine and isoleucine degradation; Carbohydrate Metabolism - butanoate; Carbohydrate Metabolism - propanoate; EC 4.2.1.17; Lipid Metabolism - fatty acid; Lipid Metabolism - fatty acid elongation in mitochondria; Lyase; Mitochondrial; Other Amino Acids Metabolism - beta-alanine; Secondary Metabolites Metabolism - limonene and pinene degradation Q8BH95 93747 7|7 F4 mouse K101-ac 467120 FAAGADIkEMQNRTF ECH_1 protein degradation; ubiquitination; intracellular localization; enzymatic activity, inhibited carcinogenesis, induced; signaling pathway regulation 28878358 1 7 16 activates mTOR signaling -SCN8A SCN8A Channel, sodium; Membrane protein, integral; Membrane protein, multi-pass Q9UQD0 6334 12q13.13 human T642-p 1869659201 RSVKRNStVDCNGVV Na_trans_cytopl activity, induced; activity, inhibited neural plasticity 32611770; 35805192 2 1 0 Regulates voltage-gated sodium channel Nav1.6 activity and neuronal excitability -Mapt Tau ACETYLTRANSFERASE; Acetyltransferase; Cytoskeletal P19332 29477 10q32.1 rat S707-p 449081 GAEIVYKsPVVSGDT neural plasticity 33519375; 33797746 192 49 90 -SF1 SF1 RNA splicing; RNA-binding; Spliceosome; Transcription, coactivator/corepressor Q15637 7536 11q13.1 human S80-p 452434 PPNPEDRsPSPEPIY SF1-HH molecular association, regulation RNA splicing, altered U2AF2(INDUCES) 16420481 1 91 12 facilitates formation of the SF1-U2AF-RNA complex -KRT5 K5 Cytoskeletal P13647 3852 12q13.13 human T151-p 288031706 TVNQSLLtPLNLQID Keratin_2_head molecular association, regulation cytoskeletal reorganization HSP70(INDUCES) 29080682 2 1 0 phosphomimetic T150 K5 mutation prevents keratin network formation in the absence of wildtype keratins; impairs keratin filament network assembly and, conversely, favors disassembly of keratin filaments ; keratin filament (KF) network -XRCC1 XRCC1 DNA repair, damage P18887 7515 19q13.31 human T488-p 451452 GAEDSGDtEDELRRV molecular association, regulation; intracellular localization PARP1(DISRUPTS); Pnk1(INDUCES) 15066279; 25477519 4 16 0 -INSIG1 INSIG1 Membrane protein, integral; Membrane protein, multi-pass O15503 3638 7q36.3 human K158-ub 486339 LGEPHKFkREWASVM INSIG protein degradation 16399501; 16549805 2 0 0 INSIG1 is degraded more rapidly than INSIG2 which controlled by serine residues flanking the ubiquitination sites in both proteins. -Smpd3 SMPD3 EC 3.1.4.12; Lipid Metabolism - sphingolipid; Membrane protein, integral; Phospholipase Q9JJY3 58994 8|8 D3 mouse S299-p 9430287 SPSASREsLVKARAG protein stabilization; enzymatic activity, induced 22074919 1 4 4 -OTUD3 OTUD3 DEUBIQUITINASE; EC 3.4.19.12 Q5T2D3 23252 1p36.13 human K129-ac 1875273800 KHVASLAkPGTFAGN OTU enzymatic activity, induced 32679077; 35675783 2 1 0 -Irs2 IRS2 Adaptor/scaffold; Motility/polarity/chemotaxis P81122 384783 8 A1.1|8 5.35 cM mouse Y649-p 454969 NLGADDGyMPMTPGA molecular association, regulation; phosphorylation signaling pathway regulation PIK3R1(INDUCES) 24811175 1 27 520 promotes GSK3B phosphorylation, regulates aerobic glycolysis -Arhgef15 ephexin-5 GEF; GEF, Rac/Rho Q5FWH6 442801 11|11 B3 mouse S107-p 17546056 PSPVSRRsISPEPAP activity, induced cytoskeletal reorganization 30485813 1 1 0 Suppression of hippocampal dendritic spine formation; RhoA activation -Nrip1 RIP140 Nuclear receptor co-regulator; Transcription, coactivator/corepressor Q8CBD1 268903 16|16 C3.1 mouse S1003-p 455634 VTDHRTFsYPGMVKT NRIP1_repr_4 molecular association, regulation; methylation; intracellular localization transcription, altered 14-3-3 beta(INDUCES); PRMT1(INDUCES) 18628823 1 5 0 regulates fat accumulation -Irs1 IRS1 Adaptor/scaffold; Motility/polarity/chemotaxis P35569 16367 1 C5|1 42.0 cM mouse S662-p 2352501 PNGYMMMsPSGSCSP molecular association, regulation PIK3C2A(DISRUPTS) 10092613 2 1 6 -TIRAP TIRAP Adaptor/scaffold P58753 114609 11q24.2 human T28-p 63052800 MADWFRQtLLKKPKK protein degradation; molecular association, regulation; ubiquitination; protein conformation 28225045 1 0 0 Reduced phosphoinositide (PI) binding -Cebpa C/EBP-alpha DNA-binding; Transcription factor P05554 24252 1q21 rat S248-p 449826 GLPGPGGsLKGLAGP activity, induced cell differentiation, altered; transcription, inhibited; cell growth, altered 11978795; 18302931; 26153766 4 0 0 -LIN37 F25965 Q96GY3 55957 19q13.12 human S182-p 453530 ACRSRIPsPLQPEMQ LIN37 molecular association, regulation LIN52(INDUCES) 21498570 1 22 13 -TRPV4 TRPV4 Channel, cation; Membrane protein, integral; Membrane protein, multi-pass Q9HBA0 59341 12q24.11 human S162-p 10272403 FDIVSRGsTADLDGL activity, induced 19661060 1 1 0 -RET Ret EC 2.7.10.1; KINASE; Kinase, protein; Membrane protein, integral; Oncoprotein; Protein kinase, TK; Protein kinase, tyrosine (receptor) P07949 5979 10q11.21 human Y928-p 3078002 ESLFDHIyTTQSDVW PK_Tyr_Ser-Thr enzymatic activity, induced 11956105 2 1 0 -SKP2 SKP2 Cell cycle regulation; UBIQUITIN LIGASE; Ubiquitin conjugating system; Ubiquitin ligase Q13309 6502 5p13.2 human S72-p 480507 PPRKRLKsKGSDKDF activity, induced; protein stabilization; phosphorylation cell cycle regulation 20663873; 26636645 5 8 5 -WIZ WIZ C2H2-type zinc finger protein O95785 58525 19p13.12 human K967-m1 10414258 PAVNKAIkSPPGFSA molecular association, regulation L3MBTL iso4(INDUCES) 23583077 0 3 16 -EIF5A2 EIF5A2 Q9GZV4 56648 3q26.2 human K121-ub 964512656 LPEGELGkEIEGKYN eIF-5a protein degradation 35064108 1 2 0 regulate EMT, and may inhibit the metastasis of CRC -AKT1 Akt1 EC 2.7.11.1; KINASE; Kinase, protein; Oncoprotein; Protein kinase, AGC; Protein kinase, Ser/Thr (non-receptor) P31749 207 14q32.33 human T72-p 460648 TERPRPNtFIIRCLQ PH enzymatic activity, induced apoptosis, inhibited 16549426 2 0 1 doxorubicin-induced apoptosis -DYRK2 DYRK2 iso2 EC 2.7.12.1; KINASE; Kinase, protein; Protein kinase, CMGC; Protein kinase, dual-specificity (non-receptor) Q92630-2 8445 12q15 human Y309-p 454666 EHQRVYTyIQSRFYR Pkinase cell cycle regulation; apoptosis, induced 34363019 1 44 1649 -RELA NFkB-p65 DNA-binding; Nuclear receptor co-regulator; Transcription factor Q04206 5970 11q13.1 human K62-ub 25087014 TKTHPTIkINGYTGP RHD_DNA_bind protein degradation transcription, inhibited 23624912 2 1 0 -CDCA8 Borealin Cell cycle regulation; Nucleolus Q53HL2 55143 1p34.3 human T94-p 4203201 ATADLDItEINKLTA cell cycle regulation; cytoskeletal reorganization 18243099 2 0 0 chromosome alignment in mitosis -ENO1 ENO1 Carbohydrate Metabolism - glycolysis and gluconeogenesis; EC 4.2.1.11; Lyase; Transcription, coactivator/corepressor P06733 2023 1p36.23 human S419-p 7104866 RIEEELGsKAKFAGR Enolase_C cell growth, induced; signaling pathway regulation 26096821 2 33 0 -GLI3 GLI3 C2H2-type zinc finger protein; Transcription factor P10071 2737 7p14.1 human S1006-p 15501397 GHGVRRAsDPVRTGS protein processing transcription, inhibited 10693759 1 4 4 -PDE10A PDE10A iso2 EC 3.1.4.17; EC 3.1.4.35; Nucleotide Metabolism - purine; Phosphodiesterase Q9Y233-2 10846 6q27 human C11-pa 15169800 GPSNNAScFRRLTEC intracellular localization 20610737 1 0 0 -Sox11 SOX11 DNA-binding; Transcription factor Q7M6Y2 20666 12|12 A2 mouse S244-p 454322 SVAKVPAsPTLSSAA protein degradation cell differentiation, induced 34431536 1 3 0 -Ppp1r12a MYPT1 Motility/polarity/chemotaxis; PHOSPHATASE; Protein phosphatase, regulatory subunit Q9DBR7 17931 10 D1|10 56.33 cM mouse T694-p 448587 ARQSRRStQGVTLTD enzymatic activity, inhibited; phosphorylation 10601309; 37057180 66 42 226 induces MLC phosphorylation -H3C1 H3 DNA-binding P68431 8350 6p22.2 human K36-ac 466364 APATGGVkKPHRYRP Histone molecular association, regulation; intracellular localization chromatin organization, altered; transcription, induced polybromo 1(INDUCES) DNA(INDUCES); DNA(DISRUPTS) 17189264; 19884317; 20368734; 20720004 8 7 6 -PACS1 PACS-1 Adaptor/scaffold Q6VY07 55690 11q13.1-q13.2 human S278-p 2911721 SPDIDNYsEEEEESF activity, induced; molecular association, regulation TXN(DISRUPTS) 14633983 1 1 0 increases binding to HIV Nef protein -TRPM4 TRPM4 Membrane protein, integral; Membrane protein, multi-pass Q8TD43 54795 19q13.33 human S839-p 36400700 GLSGGGGsLASGGPG Ion_trans intracellular localization 25231975 1 1 0 basolateral localization -POU4F1 POU4F1 Cell development/differentiation; DNA-binding; Transcription factor Q01851 5457 13q31.1 human S121-p 6322100 GDLLDHIsSPSLALM activity, induced cell differentiation, induced; transcription, induced 16126301 1 0 0 -NR3C1 GR DNA-binding; Mitochondrial; Nuclear receptor; Transcription factor P04150 2908 5q31.3 human K277-sm 2532301 NVTLPQVkTEKEDFI GCR protein degradation transcription, induced; transcription, inhibited 12144530; 12193561 5 3 0 -Fxyd1 PLM Cell surface; Channel, misc.; Membrane protein, integral Q9Z239 56188 7|7 B1 mouse S83-p 451424 EEGTFRSsIRRLSSR intracellular localization 16371442 22 20 60 After stimulation with phorbol ester. -IKBKE IKKE EC 2.7.11.10; Inhibitor; KINASE; Kinase, protein; Protein kinase, Other; Protein kinase, Ser/Thr (non-receptor) Q14164 9641 1q32.1 human K401-ub 40323318 DPALDVPkFVPKVDL TBK1_CCD1 molecular association, regulation; phosphorylation; enzymatic activity, induced carcinogenesis, induced; cell growth, induced; transcription, induced IKKB(INDUCES); IKKG(INDUCES) 23453969 1 2 0 regulates NF-kB pathway activation- TLR signaling, enhanced CYLD phosphorylation -SREBF1 SREBP-1 iso3 DNA-binding; Membrane protein, integral; Membrane protein, multi-pass; Transcription factor P36956-3 6720 17p11.2 human S39-p 23940711 AGGTDPAsPDTSSPG transcription, induced 25353341 2 1 0 mRNA expression of central SREBP-1 target genes; Phosphorylation interferes with lipid metabolism and the secretory activity of liver cells. -LRP1 LRP1 Cell surface; Membrane protein, integral; Motility/polarity/chemotaxis; Receptor, misc. Q07954 4035 12q13.3 human S4520-p 450168 GGHGSRHsLASTDEK molecular association, regulation; receptor desensitization, altered; receptor internalization, altered GULP1(INDUCES); DAB1(INDUCES); SHC1(INDUCES) 11158305; 15272003 2 23 0 -EPAS1 HIF2A DNA-binding; Transcription factor Q99814 2034 2p21 human S672-p 56668652 APLGPPVsPPHVSTF molecular association, regulation; intracellular localization transcription, induced Exportin-1(DISRUPTS) 30962349 2 2 0 inhibition of CRM1-dependent nuclear export -NANOG NANOG Cell development/differentiation; DNA-binding; Transcription factor Q9H9S0 79923 12p13.31 human T78-p 28070706 SPKGKQPtSAEKSVA transcription, induced 23708658 1 2 0 -ILK ILK EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, Ser/Thr (non-receptor); Protein kinase, TKL Q13418 3611 11p15.4 human S246-p 479407 CPRLRIFsHPNVLPV PK_Tyr_Ser-Thr intracellular localization; phosphorylation carcinogenesis, induced; cell motility, induced; cell growth, induced; cell motility, altered; transcription, induced 17420447; 35810788 8 0 0 regulates GSK3B phosphorylation, and ?-catenin phosphorylation and nuclear translocation -DNPEP DNPEP iso2 EC 3.4.11.21; Protease Q9ULA0-2 23549 2q35 human S109-p 34733463 VKRRSRRsQVGFQQV Peptidase_M18 protein degradation; molecular association, regulation; ubiquitination carcinogenesis, inhibited; cell growth, inhibited; cell motility, inhibited; signaling pathway regulation USP4(DISRUPTS) 31219614 1 1 8 PAK5-DNPEP-USP4 pathway; inhibits invasion and migration -TLE1 TLE1 Nuclear receptor co-regulator; Transcription, coactivator/corepressor Q04724 7088 9q21.32 human S239-p 454385 KDSSHYDsDGDKSDD activity, induced apoptosis, inhibited; transcription, induced; transcription, altered; cell growth, altered 15367661; 22354967; 24270405 3 5 1 -Lrp1 LRP1 Cell surface; Membrane protein, integral; Motility/polarity/chemotaxis; Receptor, misc. G3V928 299858 7q22 rat Y4508-p 451245 TNFTNPVyATLYMGG molecular association, regulation GRB2(INDUCES); CSK(INDUCES); PLCG1(INDUCES); SNX17(DISRUPTS); SHP-2(INDUCES); 14-3-3 gamma(DISRUPTS); PIK3R1(INDUCES) 19771558 6 1 0 -SSH1 SSH1 EC 3.1.3.16; EC 3.1.3.48; PHOSPHATASE; Protein phosphatase, dual-specificity Q8WYL5 54434 12q24.11 human S978-p 455275 SPLKRSHsLAKLGSL molecular association, regulation; intracellular localization; activity, inhibited; phosphorylation cell motility, altered 14-3-3 beta(INDUCES); 14-3-3 zeta(INDUCES) 15159416; 19329994; 19567672; 21525957 9 1 0 -Slc10a1 NTCP Membrane protein, integral; Membrane protein, multi-pass; Transporter P26435 24777 6q24 rat T225-p 31080200 MTPHLLAtSSLMPFS endocytosis, induced 24008362 1 0 0 PMA induced internalization of NTCP -Slc12a5 KCC2 Membrane protein, integral; Membrane protein, multi-pass; Transporter; Transporter, SLC family Q63633 171373 3q42 rat S963-p 487533 ITDESRGsIRRKNPA SLC12 protein stabilization 17693402 23 5 2 -TARDBP TDP-43 RNA-binding Q13148 23435 1p36.22 human S410-p 3084601 SSMDSKSsGWGM___ molecular association, regulation; ubiquitination; intracellular localization; activity, inhibited; protein conformation; phosphorylation RNA splicing, induced; autophagy, induced; apoptosis, induced; RNA stability, inhibited; autophagy, altered; transcription, inhibited TDP-43(INDUCES); TDP-43(DISRUPTS) 19164285; 19515851; 21062285; 22198567; 24105464; 24466128; 24595055; 27445339; 28599005; 29311743; 29623031; 29987190; 30120199; 30559480; 34107054; 35112738 54 4 0 inhibited mTOR activity and dynactin expression, induced neuronal injury; primes phosphorylation at other sites; phosphomimetic S410/409D mutant reduces TARDBP aggregation and autophagy; induces cytotoxicity and oligomerization; promotes cytoplasmic aggregation -Icam1 ICAM1 Cell adhesion; Immunoglobulin superfamily; Membrane protein, integral P13597 15894 9 A3|9 7.69 cM mouse Y518-p 450460 RQRKIRIyKLQKAQE molecular association, regulation; intracellular localization cell adhesion, induced; cytoskeletal reorganization Actinfilin(INDUCES); ACTB(INDUCES) 21474822 5 0 1 -EWSR1 EWS Oncoprotein; RNA-binding; Transcription, coactivator/corepressor Q01844 2130 22q12.2 human Y656-p 20473605 QERRDRPy_______ intracellular localization 21647358 1 0 0 nuclear import -AMOTL1 AMOTL1 Adaptor/scaffold Q8IY63 154810 11q21 human S793-p 7103446 SSLRPARsVPSIAAA Angiomotin_C protein stabilization 25373897 1 20 2 -Fscn1 fascin Actin-binding; Cytoskeletal; Motility/polarity/chemotaxis Q61553 14086 5 G2|5 81.84 cM mouse S39-p 450888 KVNASASsLKKKQIW Fascin molecular association, regulation; intracellular localization cell motility, altered; cytoskeletal reorganization; signaling pathway regulation; cell adhesion, inhibited ACTA1(DISRUPTS); ACTB(DISRUPTS) 10588651; 16966425; 23884926; 28855604; 30683702 13 12 0 -ASB8 ASB8 Q9H765 140461 12q13.11 human S17-p 1869062300 QSIQSKYsLSERLIR signaling pathway regulation 32298923 1 0 0 IFN-beta signaling, TBK1/IKKi ubiquitination and degradation; inhibition of IRF3 pathway -LRP6 LRP6 Membrane protein, integral; Receptor, misc. O75581 4040 12p13.2 human S1420-p 460717 YVVHGPAsVPLGYVP molecular association, regulation carcinogenesis, induced; cell growth, induced; transcription, induced; signaling pathway regulation axin 1(DISRUPTS) 16513652; 35277657 2 0 0 induces Wnt/?-catenin signaling pathway -RACK1 RACK1 Adaptor/scaffold; G protein; G protein, heterotrimeric; G protein, heterotrimeric beta; Motility/polarity/chemotaxis; Nuclear receptor co-regulator P63244 10399 5q35.3 human Y302-p 2850000 GQTLFAGyTDNLVRV WD40 molecular association, regulation cell motility, altered; cell growth, altered PPP2CA(INDUCES); ITGB1(INDUCES) 18567578 1 0 0 phosphorylation of this site stimulates binding of RACK1 to PPP2CA, whereas does not affect its binding to ITGB1 -SLC3A2 SLC3A2 Membrane protein, integral; Transporter P08195 6520 11q12.3 human S408-p 6003503 TSSYLSDsGSTGEHT cell adhesion, altered 19065266 1 0 0 enhances cell- cell interactions -PFN1 profilin 1 Actin-binding; Cytoskeletal; Motility/polarity/chemotaxis P07737 5216 17p13.2 human S72-p 15413723 TLGGQKCsVIRDSLL Profilin molecular association, regulation; intracellular localization carcinogenesis, induced; apoptosis, inhibited; signaling pathway regulation; cell growth, altered ACTA1(DISRUPTS) 34235154 1 4 1 destabilizes I?Ba and increases NFkB signaling -TOM1L1 Srcasm Adaptor/scaffold O75674 10040 17q22 human Y392-p 451208 NLTSSHAyDNFLEHS molecular association, regulation; intracellular localization endocytosis, altered GRB2(INDUCES); EGFR(INDUCES) 19798056 3 0 1 regulates EGF-stimulated endocytosis of EGFR -F11R JAM-A Cell adhesion; Membrane protein, integral Q9Y624 50848 1q23.3 human T273-p 1783000 FDRTKKGtSSKKVIY cytoskeletal reorganization 18096610 1 1 0 important for development of hepatic polarity -Cdh1 CDH1 Cell adhesion; Membrane protein, integral; Motility/polarity/chemotaxis; UBIQUITIN LIGASE; Ubiquitin ligase P09803 12550 8 D3|8 53.18 cM mouse Y755-p 456024 DDTRDNVyYYDEEGG molecular association, regulation CBLL1(INDUCES) 11836526 2 2 42 -MAP4K3 KHS2 EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, STE; Protein kinase, Ser/Thr (non-receptor) Q8IVH8 8491 2p22.1 human Y735-p 23117826 LVVPEQEyPLVCVGV CNH molecular association, regulation IQGAP1(INDUCES) 31431460 0 1 1 -RASGRP3 RASGRP3 GEF; GEF, Ras Q5ZID9 421460 chicken T133-p 454419 YDWMRRVtQRKKISK activity, induced 15545601 2 0 0 -Map3k2 MEKK2 EC 2.7.11.25; KINASE; Kinase, protein; Protein kinase, STE; Protein kinase, Ser/Thr (non-receptor) F1M9D0 171492 18p12 rat S153-p 3216819 AERKKRLsVVGPPNR apoptosis, induced 28039298 3 51 11 -FPR1 FPR1 GPCR, family 1; Membrane protein, integral; Membrane protein, multi-pass; Motility/polarity/chemotaxis; Receptor, GPCR P21462 2357 19q13.41 human T334-p 450843 DSTQTSDtATNSTLP receptor desensitization, altered; receptor internalization, altered 10514456 2 1 0 -HSF1 HSF1 DNA-binding; Transcription factor Q00613 3297 8q24.3 human S338-p 40853700 IDSILREsEPAPASV Vert_HS_TF transcription, inhibited 25963659 1 0 0 under non-stressed conditions, upon heat shock S to A mutant showed 60% higher luciferase activity -RAG2 RAG2 Cell development/differentiation; Histone-binding; Lipid-binding P55895 5897 11p12 human T490-p 455560 EIARALHtPQRVLPL RAG2_PHD protein degradation; molecular association, regulation; ubiquitination carcinogenesis, altered SKP2(INDUCES) 15949444; 21349429 4 0 0 RAG2 T490A mutation induces lymphoid malignancies -LRP6 LRP6 Membrane protein, integral; Receptor, misc. O75581 4040 12p13.2 human S1431-p 460718 GYVPHPSsLSGSLPG molecular association, regulation axin 1(DISRUPTS) 16513652 1 0 0 -PLIN1 perilipin 1 Lipid-binding O60240 5346 15q26.1 human S522-p 471365 YSQLRKKs_______ intracellular localization 29688805 11 0 1 adrenergic control of lipolysis ; OPA1 is indispensable for HSL translocation to LDs and its phosphorylation on S650 and S552 -Smo SMO Cell development/differentiation; GPCR, Fz/Smo family; Membrane protein, integral; Membrane protein, multi-pass; Oncoprotein; Receptor, GPCR P56726 319757 6 A3.3|6 12.36 cM mouse S560-p 1872776110 WCRLTGHsDDEPKRI molecular association, regulation transcription, induced PKACA(INDUCES) 33886552 1 1 0 -RPA2 RFA2 DNA replication P15927 6118 1p35.3 human S13-p 1854601 FESYGSSsYGGAGGY molecular association, regulation; intracellular localization DNA repair, induced; cell growth, altered WRN(INDUCES) 17035231; 21107010 3 0 1 upon replication blockage, WRN and RPA functionally interact ; 7xAlanine mutant has defect in down regulating DNA synthesis following UV treatment. 7xAspartate mutant did not localize to S-phase foci. -Plk4 PLK4 EC 2.7.11.21; KINASE; Kinase, protein; Nucleolus; Protein kinase, Other; Protein kinase, Ser/Thr (non-receptor) Q64702 20873 3|3 B mouse S305-p 12122401 SGTSLSGsLLDRRLL protein degradation; ubiquitination; intracellular localization 20100909; 25174401 4 1 0 localizes in protrusions -S Spike Glycoprotein P59594 1489668 SARSCoV1 S1243-p 1868174975 CKFDEDDsEPVLKGV intracellular localization 16099010 1 1 0 retention of spike (S) glycoprotein at cell surface -LATS1 LATS1 EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, AGC; Protein kinase, Ser/Thr (non-receptor); Tumor suppressor O95835 9113 6q25.1 human K751-sm 62518205 RNQVAHVkAERDILA Pkinase enzymatic activity, inhibited; phosphorylation carcinogenesis, induced; cell growth, induced; apoptosis, inhibited; signaling pathway regulation 27847303 1 0 0 inhibition of Hippo signaling pathway, decrease in YAP and TAZ phosphorylation (Hippo pathway); Sumoylation of K751 destabilizes the phosphorylated T1079 resulting in a decrease of LATS1 enzymatic activity. -Gli2 GLI2 C2H2-type zinc finger protein; Oncoprotein; Transcription factor Q0VGT2 14633 1 E2.3|1 52.17 cM mouse S956-p 15501376 NSSTRRAsDPVRRPD sumoylation 22549777 1 5 4 -BTK Btk EC 2.7.10.2; KINASE; Kinase, protein; Protein kinase, TK; Protein kinase, tyrosine (non-receptor) Q06187 695 Xq22.1 human Y223-p 447485 LKKVVALyDYMPMNA SH3_1 enzymatic activity, induced cell adhesion, induced; cell growth, altered 14597636; 34162728; 37197664; 8630736 41 14 250 BTK*/Y223F mutant showed increased transformation, as compared to BTK*. -Ikzf1 Ikaros C2H2-type zinc finger protein; DNA-binding; Transcription factor Q03267 22778 11 A1|11 7.02 cM mouse S386-p 451350 SEREASPsNSCQDST activity, inhibited cell cycle regulation DNA(DISRUPTS) 15024069 2 1 2 -ATAT1 ATAT1 ACETYLTRANSFERASE; Acetyltransferase; EC 2.3.1.108 Q5SQI0 79969 6p21.33 human T322-p 480007 SPAQRRRtRGTPPGL molecular association, regulation; intracellular localization 14-3-3 beta(INDUCES); 14-3-3 zeta(INDUCES); 14-3-3 epsilon(INDUCES); 14-3-3 gamma(INDUCES); KPNA4(DISRUPTS); KPNA6(DISRUPTS); KPNA2(DISRUPTS) 36222836 1 0 2 -CHEK2 Chk2 EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, CAMK; Protein kinase, Ser/Thr (non-receptor); Tumor suppressor O96017 11200 22q12.1 human S73-p 2251701 VSTQELYsIPEDQEP molecular association, regulation; phosphorylation; enzymatic activity, induced cell cycle regulation 16481012 1 1 0 -CYLD CYLD DEUBIQUITINASE; EC 3.4.19.12; Protease; Tumor suppressor; Ubiquitin conjugating system; Ubiquitin-specific protease Q9NQC7 1540 16q12.1 human K338-ub 1878249900 SSSHNKPkATGSTSD protein degradation signaling pathway regulation 31366726 1 1 0 enhances NF-kB signaling. -TRIP6 TRIP6 Adaptor/scaffold; Motility/polarity/chemotaxis; Nuclear receptor co-regulator Q15654 7205 7q22.1 human Y55-p 456050 PLPSEQCyQAPGGPE molecular association, regulation; intracellular localization carcinogenesis, altered; cell motility, induced; cell motility, altered 17591779; 20876301; 23576104 5 4 43 -TP63 p63 DNA-binding; Transcription factor Q9H3D4 8626 3q28 human S395-p 451602 TSIKKRRsPDDELLY P53_tetramer transcription, induced 35623662 2 4 0 -DCLRE1C Artemis DNA repair, damage; Deoxyribonuclease; EC 3.1.-.- Q96SD1 64421 10p13 human S516-p 460660 SSTVAGGsQSPKLFS molecular association, regulation; ubiquitination; intracellular localization cell cycle regulation FBXW7(INDUCES); NBS1(INDUCES); MRE11A(INDUCES) 15723659; 16600297; 17242184; 19423708 8 3 1 facilitates recovery from the replication checkpoint in response to DNA damage; Artermis regulates Cdk1-cyclin B during IR-induced G2/M arrest and Cdk1-cyclin B nuclear import.; interaction with FBXW7 stimulates ubiquitination and degradation of cyclin E -TERF2 TRF2 DNA repair, damage; DNA-binding Q15554 7014 16q22.1 human R60-me 10338213 SGRAAGRrASRSSGR cell cycle regulation; cell growth, altered 19596784 1 0 0 -CEACAM1 CEACAM1 Cell adhesion; Immunoglobulin superfamily; Membrane protein, integral; Motility/polarity/chemotaxis P13688 634 19q13.2 human S508-p 448536 QQPTQPTsASPSLTA activity, induced; molecular association, regulation; intracellular localization; enzymatic activity, induced; phosphorylation apoptosis, induced; transcription, altered; cell growth, altered CD36(DISRUPTS) 11278391; 11313949; 23499736; 34656562; 34666041 11 2 0 regulates CD36 nuclear translocation, inhibits AMPK phosphorylation and activation; influences phosphorylation of residues Y493 and Y520 -NEK7 NEK7 EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, Other; Protein kinase, Ser/Thr (non-receptor) Q8TDX7 140609 1q31.3 human Y97-p 12475500 NHPNVIKyYASFIED Pkinase enzymatic activity, inhibited; protein conformation apoptosis, altered 19941817 1 0 0 autoinhibition -CAMK4 CAMK4 EC 2.7.11.17; KINASE; Kinase, protein; Protein kinase, CAMK; Protein kinase, Ser/Thr (non-receptor) Q16566 814 5q22.1 human T200-p 448164 EHQVLMKtVCGTPGY Pkinase molecular association, regulation; enzymatic activity, induced transcription, induced; transcription, altered OGA(DISRUPTS) 15143065; 15769749; 19506079; 8702940 11 7 8 -Cbl CBL Adaptor/scaffold; EC 6.3.2.-; EC 6.3.2.19; Ligase; Motility/polarity/chemotaxis; Oncoprotein; UBIQUITIN LIGASE; Ubiquitin conjugating system; Ubiquitin ligase P22682 12402 9 A5.1-A5.2|9 24.72 cM mouse Y737-p 448530 QQIDSCTyEAMYNIQ molecular association, regulation; phosphorylation cytoskeletal reorganization Src(INDUCES) 20133944; 21967979; 34019873 17 1 34 -RET Ret EC 2.7.10.1; KINASE; Kinase, protein; Membrane protein, integral; Oncoprotein; Protein kinase, TK; Protein kinase, tyrosine (receptor) P07949 5979 10q11.21 human S891-p 455478 EGRKMKIsDFGLSRD PK_Tyr_Ser-Thr phosphorylation transcription, altered 15753368 1 0 0 STAT3 Y705 phosphorylation -DDX19A DDX19A EC 3.6.4.13; Helicase Q9NUU7 55308 16q22.1 human K26-sm 55429484 SMTNLQIkEEKVKAD molecular association, regulation; intracellular localization GLE1(INDUCES) 35080244 1 3 0 enriched at the nuclear envelope, regulates mRNA export from nucleus -SMURF2 SMURF2 EC 6.3.2.-; EC 6.3.2.19; Ligase; UBIQUITIN LIGASE; Ubiquitin conjugating system; Ubiquitin ligase Q9HAU4 64750 17q23.3-q24.1 human R232-m1 56854401 DPRLAERrVRSQRHR protein degradation 26126536 1 0 0 -AURKA AurA EC 2.7.11.1; KINASE; Kinase, protein; Oncoprotein; Protein kinase, Other; Protein kinase, Ser/Thr (non-receptor) O14965 6790 20q13.2 human K75-ac 1873284338 HKPVQNQkQKQLQAT enzymatic activity, induced cell cycle regulation; carcinogenesis, induced; cell motility, induced; cell growth, induced 28915666 1 0 0 may lead to development of cancer -Fcer1g FCER1G Membrane protein, integral; Receptor, misc. P20491 14127 1 H3|1 79.23 cM mouse Y76-p 454847 NTRSQETyETLKHEK ITAM molecular association, regulation; phosphorylation endocytosis, induced Syk(INDUCES); Cbl-b(DISRUPTS) 18715866; 27428899 4 16 204 -PIN1 PIN1 EC 5.2.1.8; Isomerase; Nuclear receptor co-regulator Q13526 5300 19p13.2 human K6-sm 31094510 __MADEEkLPPGWEK protein degradation; molecular association, regulation; enzymatic activity, inhibited carcinogenesis, inhibited; cell growth, inhibited; transcription, inhibited FOXM1(DISRUPTS) 23633483 1 2 0 inhibits cyclin D1 stability -STXBP5L STXBP5L Q9Y2K9 9515 3q13.33 human S820-p 3941523 YNRSRSSsISSIDKD Lgl_C protein degradation 25002582 1 8 14 ; in a multiple residue S->D mutant -DOCK8 DOCK8 GEF; GEF, misc.; Motility/polarity/chemotaxis Q8NF50 81704 9p24.3 human S2087-p 4041179 RDSFHRSsFRKCETQ molecular association, regulation cell motility, induced LRCH1(DISRUPTS) 28028151 1 2 7 -CHEK1 Chk1 EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, CAMK; Protein kinase, Ser/Thr (non-receptor); Tumor suppressor O14757 1111 11q24.2 human T382-p 1388511400 KRMTRFFtKLDADKS protein degradation; enzymatic activity, induced cell cycle regulation 30510197 1 0 0 -Gja1 GJA1 Channel, misc.; Membrane protein, integral; Membrane protein, multi-pass; Motility/polarity/chemotaxis P08050 24392 20q11 rat S255-p 448852 HATTGPLsPSKDCGS activity, inhibited 9535909 23 21 1 -Kdr VEGFR2 EC 2.7.10.1; KINASE; Kinase, protein; Membrane protein, integral; Protein kinase, TK; Protein kinase, tyrosine (receptor) P35918 16542 5 C3.3|5 40.23 cM mouse Y994-p 447904 EEASEELyKDFLTLE PK_Tyr_Ser-Thr signaling pathway regulation 25119572 7 0 0 -KLF3 KLF3 C2H2-type zinc finger protein; DNA-binding; Transcription factor P57682 51274 4p14 human S250-p 4728795 KRPLPVEsPDTQRKR molecular association, regulation transcription, inhibited DNA(INDUCES) 25659434 1 41 0 -GTSE1 GTSE1 Apoptosis; Cell cycle regulation Q9NYZ3 51512 22q13.31 human S454-p 10405611 RSIRRRDsCLNSKTK intracellular localization cell cycle regulation 20577264 1 4 27 important for p53 inactivation during G2 checkpoint recovery -Hsf1 HSF1 DNA-binding; Transcription factor P38532 15499 15 D3|15 35.95 cM mouse S121-p 455480 NIKRKVTsVSTLKSE intracellular localization; activity, inhibited 25425574 5 7 1 HSF1 inactivation, supresses Proteotoxic stress response, impaired nuclear translocation -SVIL supervillin Actin-binding; Contractile; Motility/polarity/chemotaxis; Nuclear receptor co-regulator Q6U1J6 ferret S132-p 7721700 DSEADSEsPSRYTKS molecular association, regulation ERK1(DISRUPTS); ERK2(DISRUPTS) 19406750 1 3 11 in vitro -Arhgef7 ARHGEF7 GEF; GEF, Rac/Rho; Motility/polarity/chemotaxis O55043 114559 16q12.5 rat S516-p 455215 RKPERKPsDEEFAVR RhoGEF67_u2 molecular association, regulation; intracellular localization cytoskeletal reorganization 14-3-3 beta(INDUCES); CDC42 iso1(INDUCES); RAC1(INDUCES) 15513924; 18160719; 18184567 4 54 30 -PAK3 PAK3 EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, STE; Protein kinase, Ser/Thr (non-receptor) O75914 5063 Xq23 human S259-p 470118 TDRQRKKsKMTDEEI cytoskeletal reorganization 17077177 1 0 0 Mutation of any of the 4 serines/threonines to alanine reduced the AILIM/ICOS-induced elongation ratio in activated T cells. Three sites are believed to be autophosphorylation sites, and one is believed to be an Akt1 site. Treatment with Akt inhibitor shows a reduction in this elongation ratio. -SLC9A1 NHE1 Membrane protein, integral; Membrane protein, multi-pass; Motility/polarity/chemotaxis; Transporter; Transporter, SLC family P19634 6548 1p36.11 human S785-p 1983418 FTPAPSDsPSSQRIQ activity, induced; protein stabilization; protein conformation 23678047; 28554535 3 49 28 -Dnm2 DYN2 EC 3.6.5.5; Hydrolase; Microtubule-binding; Motility/polarity/chemotaxis; Vesicle P39052 25751 8q13 rat Y231-p 451199 LLPLRRGyIGVVNRS Dynamin_M molecular association, regulation; intracellular localization carcinogenesis, induced; cell motility, induced; cell growth, induced; exocytosis, induced; cytoskeletal reorganization caveolin-1(INDUCES) 15007081; 20231454; 21841817 4 1 0 DYN2 Y597 is required for endocytosis and albumin transport. ; Golgi integrity and vesiculation during the secretory process; Wild-type showed increased motility and increase of large distal tumors, compared to Y231/597F mutant. -Hcn4 HCN4 Channel, cation; Membrane protein, integral; Membrane protein, multi-pass O70507 330953 9|9 B mouse S1142-p 4699522 PRKTSSGsLPPPLSL activity, induced 20713547 1 0 0 required for PKA to shift the voltage dependence of HCN4 -Diaph3 Diaphanous-3 Motility/polarity/chemotaxis Q9Z207 56419 14|14 E1 mouse T1061-p 20583304 FRDRRKRtPKLKDIR activity, induced; molecular association, regulation; intracellular localization; protein conformation transcription, induced; cytoskeletal reorganization Diaphanous-3(DISRUPTS) 21699497 1 0 0 -YBX1 YB-1 RNA processing; RNA splicing; RNA-binding; Transcription factor P67809 4904 1p34.2 human K264-m2 1884032900 EDGNEEDkENQGDET molecular association, regulation carcinogenesis, induced; cell motility, induced; cell growth, induced RNA(INDUCES) 35410432 1 1 0 K264 methylation is involved in hY4F binding and sorting into lung cancer EVs; role in the proliferation, migration and invasion -SLC22A6 SLC22A6 Membrane protein, integral; Membrane protein, multi-pass; Transporter; Transporter, SLC family Q4U2R8 9356 11q12.3 human K315-ub 27202153 VLRASLQkELTMGKG Sugar_tr receptor internalization, induced 23640180 1 1 0 -ZMYM2 ZNF198 Transcription factor Q9UBW7 7750 13q12.11 human S303-p 18914809 QKQPGVDsLSPVASL molecular association, regulation; ubiquitination HDAC1(DISRUPTS); LSD1(DISRUPTS) 25855382 1 4 0 -ERBB2 HER2 EC 2.7.10.1; KINASE; Kinase, protein; Membrane protein, integral; Oncoprotein; Protein kinase, TK; Protein kinase, tyrosine (receptor) P04626 2064 17q12 human K175-m3 206216900 LWKDIFHkNNQLALT molecular association, regulation; phosphorylation signaling pathway regulation HER2(INDUCES) 28639750 1 1 0 induces HER2 autophosphorylation, homodimerization, activates Akt and PLC-gamma signaling pathways -Olig2 OLIG2 Oncoprotein; Transcription factor Q9EQW6 50913 16 C3.3|16 52.6 cM mouse S10-p 18357903 SDASLVSsRPSSPEP sumoylation cell cycle regulation; cell differentiation, altered; carcinogenesis, altered; cell growth, induced; apoptosis, inhibited; transcription, induced; cell motility, inhibited 21382551; 27396340; 32483381 4 2 0 -DNMT1 DNMT1 Amino Acid Metabolism - cysteine and methionine; Cell development/differentiation; EC 2.1.1.37; METHYLTRANSFERASE; Methyltransferase; Methyltransferase, DNA; Transcription regulation P26358 1786 19p13.2 human K975-ac 25171007 LYPEHYRkYSDYIKG BAH cell cycle regulation 21947282 1 1 0 -NME1 NME1 EC 2.7.4.6; KINASE; Kinase, nucleoside diphosphate; Kinase, other; Nucleotide Metabolism - purine; Nucleotide Metabolism - pyrimidine; Protein kinase, histidine; Tumor suppressor P15531 4830 17q21.33 human K56-ac 11319284 KEHYVDLkDRPFFAG NDK protein stabilization; molecular association, regulation cell motility, inhibited FBXO24(DISRUPTS) 25582197 1 4 0 -ITCH ITCH EC 6.3.2.-; EC 6.3.2.19; Ligase; UBIQUITIN LIGASE; Ubiquitin conjugating system; Ubiquitin ligase Q96J02 83737 20q11.22 human S687-p 397383600 IDPEFYNsLIWVKEN HECT molecular association, regulation UBE2L3(DISRUPTS) 29212706 1 0 0 -Slc40a1 SLC40A1 Membrane protein, integral; Membrane protein, multi-pass; Transporter; Transporter, SLC family Q9JHI9 53945 1|1 C1.1 mouse K240-ub 3937703 LAVKAALkVEESELK FPN1 sumoylation; ubiquitination; intracellular localization 33490642 1 2 2 Sumoylation of K240E mutation impedes Fpn trafficking and is diffused throughout the cytoplasm, and affects iron homeostasis. -Rb1 Rb Nuclear receptor co-regulator; Oncoprotein; Transcription, coactivator/corepressor; Tumor suppressor P13405 19645 14 38.73 cM|14 D3 mouse T814-p 447983 KISEGLPtPTKMTPR Rb_C molecular association, regulation; phosphorylation cell cycle regulation; chromatin organization, altered; cell growth, induced; DNA repair, inhibited E2F1(DISRUPTS); SUV420H1(DISRUPTS); SUV420H2(DISRUPTS) 10207050; 35023164 26 40 64 -Hoxa9 HOXA9 DNA-binding; Oncoprotein P09631 15405 6 B3|6 25.4 cM mouse T205-p 2906101 NWLHARStRKKRCPY molecular association, regulation cell differentiation, altered DNA(DISRUPTS) 15082777 1 0 0 -JUNB JunB Motility/polarity/chemotaxis; Oncoprotein; Transcription factor P17275 3726 19p13.13 human S259-p 452631 RDATPPVsPINMEDQ protein degradation FBXW7(INDUCES) 22710716 4 55 19 mitosis progression and chromatid cohesion -Ulk1 ULK1 Autophagy; EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, Other; Protein kinase, Ser/Thr (non-receptor) NP_001101811 360827 12q16 rat S317-p 35495300 SHLASPPsLGEMPQL autophagy, induced 33571535; 37009319 20 1 0 -NCOA3 SRC-3 ACETYLTRANSFERASE; Acetyltransferase; EC 2.3.1.48; Motility/polarity/chemotaxis; Nuclear receptor co-regulator; Transcription, coactivator/corepressor Q9Y6Q9 8202 20q13.12 human S101-p 4661901 DVQKADVsSTGQGVI protein degradation; molecular association, regulation carcinogenesis, inhibited SPOP(INDUCES) 18922467; 21577200 2 0 0 -PPARGC1A PGC-1 alpha Nuclear receptor co-regulator; Transcription, coactivator/corepressor Q9UBK2 10891 4p15.2 human S636-p 15422179 SRRPRYDsYEEYQHE protein degradation; molecular association, regulation; ubiquitination; phosphorylation carcinogenesis, induced; DNA repair, induced; apoptosis, inhibited RNF34(INDUCES) 36696363 1 1 4 decreases H2AX phosphorylation -FLT3 FLT3 EC 2.7.10.1; KINASE; Kinase, protein; Membrane protein, integral; Oncoprotein; Protein kinase, TK; Protein kinase, tyrosine (receptor) P36888 2322 13q12.2 human Y969-p 454874 VSECPHTyQNRRPFS molecular association, regulation cell cycle regulation GRB2(INDUCES); Btk(NOT_REPORTED); SHP-2(INDUCES) 19438505; 31395602 6 4 16 regulates cell proliferation -CREB1 CREB iso1 DNA-binding; Transcription factor P16220-1 1385 2q33.3 human T100-p 457131 LKRLFSGtQISTIAE activity, inhibited; phosphorylation transcription, inhibited 15073328; 17209043 3 0 0 -FLI1 FLI1 DNA-binding; Oncoprotein; Transcription factor Q01543 2313 11q24.3 human K240-ac 28108002 NMNSGLNkSPPLGGA transcription, induced 22973553 1 1 0 -Sp1 SP1 C2H2-type zinc finger protein; DNA-binding; Transcription factor Q01714 24790 7q36 rat K704-ac 12718501 MRSDHLSkHIKTHQN zf-C2H2 molecular association, regulation apoptosis, induced; transcription, induced DNA(INDUCES) 34504597 3 0 0 -TP53 p53 Activator; DNA-binding; Motility/polarity/chemotaxis; Nuclear receptor co-regulator; Transcription factor; Tumor suppressor P04637 7157 17p13.1 human T284-p 18675300 CPGRDRRtEEENLRK P53 apoptosis, altered; transcription, inhibited 20959462 1 1 0 -Cacna1c CACNA1C Channel, calcium; Membrane protein, integral; Membrane protein, multi-pass P22002 24239 4q42 rat Y1738-p 880751700 LFGNHVSyYQSDSRS CAC1F_C activity, induced 29441404 1 0 0 significantly increased the Ca2+current density of CACNA1C channels in a range of the membrane potentials -PPARD PPAR-delta DNA-binding; Nuclear receptor A9XAM2 pig K17-ub 62484401 EVREEEKkKEVAEAE transcription, induced 24058710 1 0 0 -MFN2 MFN2 Cell cycle regulation; Cytoskeletal; EC 3.6.5.-; Hydrolase; Membrane protein, integral; Membrane protein, multi-pass; Mitochondrial O95140 9927 1p36.22 human S442-p 4746700 AEEIRRLsVLVDDYQ protein degradation; intracellular localization cell cycle regulation; carcinogenesis, induced; autophagy, induced; cell growth, induced; apoptosis, inhibited 34275172; 35646911 6 2 0 miophagy -Wasf2 WAVE2 Actin-binding; Motility/polarity/chemotaxis Q5FWU0 313024 5q36 rat S137-p 4258800 PPPLNNLsPYRDDGK cell motility, altered 18701695 2 0 0 -Trp53bp1 53BP1 DNA repair, damage; Transcription, coactivator/corepressor P70399 27223 2|2 E5 mouse K1265-ub 7172000 DGTEVERkVTEETEE intracellular localization DNA repair, induced 19228710 1 0 0 -Kcnk18 KCNK18 Channel, ligand-gated; Channel, potassium; Membrane protein, integral; Membrane protein, multi-pass Q6VV64 332396 19|19 D3 mouse S264-p 2712200 RPVERSNsCPELVLG activity, induced; molecular association, regulation; protein conformation; activity, inhibited 14-3-3 beta(INDUCES); 14-3-3 gamma(INDUCES); 14-3-3 eta(INDUCES) 14981085; 18397886; 20215114; 22145024; 29763475; 32641496 8 0 1 -Dab2 DAB2 Adaptor/scaffold; Tumor suppressor P98078 13132 15 A1|15 2.15 cM mouse S24-p 451211 QAAPKAPsKKEKKKG molecular association, regulation; receptor internalization, inhibited VEGFR2(DISRUPTS); VEGFR3(DISRUPTS) 23354168 4 3 0 -Hnf4a HNF4 alpha DNA-binding; Nuclear receptor; Transcription factor P22449 25735 3q42 rat S143-p 458369 RISTRRSsYEDSSLP molecular association, regulation transcription, altered DNA(DISRUPTS) 9234678 4 3 12 -RPS3 RPS3 Apoptosis; EC 4.2.99.18; RNA-binding; Ribosomal; Translation P23396 6188 11q13.4 human T70-p 15113600 GRRIRELtAVVQKRF KH_2 activity, induced; molecular association, regulation; intracellular localization apoptosis, altered E2F1(DISRUPTS); Akt1(INDUCES) 20605787 3 2 0 upregulates the endonuclease activity of RPS3 -PDE4D PDE4D iso7 EC 3.1.4.53; Nucleotide Metabolism - purine; Phosphodiesterase Q08499-7 5144 5q11.2-q12.1 human S126-p 458388 VHSQRREsFLYRSDS enzymatic activity, induced 12023945 10 21 1 -App APP Apoptosis; Cell surface; Membrane protein, integral; Receptor, misc.; Transcription factor P12023 11820 16 C3.3|16 46.92 cM mouse S697-p 54165901 FFAEDVGsNKGAIIG Beta-APP protein conformation 26898910 2 0 0 forms oligomers without fibril formation, intraneuronal deposition, increased toxicity in human neurons -Exoc7 EXOC7 Cytoskeletal O54922 64632 10q32.1 rat S250-p 483909 SSSGVPYsPAIPNKR molecular association, regulation exocytosis, induced; cell motility, induced; cytoskeletal reorganization EXOC4(INDUCES); EXOC8(INDUCES) 22595671 1 25 6 -TRIM59 TRIM59 Membrane protein, integral; Ubiquitin conjugating system Q8IWR1 286827 3q25.33 human S308-p 50801655 LIPKMKIsPKRMSCS protein degradation; molecular association, regulation; ubiquitination; intracellular localization; protein conformation carcinogenesis, induced; transcription, induced; signaling pathway regulation H2AFY iso1(INDUCES); KPNA1(INDUCES); PIN1(INDUCES) 31488827 1 1 0 macroH2A1 degradation enhances STAT3 signaling; CDK5/TRIM59/mH2A1/STAT3 pathway -PHF8 PHF8 DEMETHYLASE; Demethylase; EC 1.14.11.27; Nucleolus Q9UPP1 23133 Xp11.22 human S69-p 15108901 CQDWFHGsCVGVEEE PHD cell growth, inhibited; cell differentiation, induced; transcription, induced 23518351 2 1 0 -AXL AXL EC 2.7.10.1; KINASE; Kinase, protein; Membrane protein, integral; Oncoprotein; Protein kinase, TK; Protein kinase, tyrosine (receptor) P30530 558 19q13.2 human Y779-p 451490 ADCLDGLyALMSRCW PK_Tyr_Ser-Thr apoptosis, inhibited; transcription, induced 33786587 8 2 2 -DEPDC1 DEPDC1 GAP; GAP, Rac/Rho Q5TB30 55635 1p31.3 human S110-p 31082615 LFRFPATsPLKTLPR intracellular localization 28602627 1 3 0 localization of DEPDC1a to the centrosome -Grm5 mGluR5 GPCR, family 3; Membrane protein, integral; Membrane protein, multi-pass; Receptor, GPCR Q3UVX5 108071 7|7 D3 mouse S1158-p 25581600 LVALTPPsPFRDSVD GluR_Homer-bdg molecular association, regulation; protein conformation PIN1(INDUCES); HOMER1(INDUCES) 22561452; 23911326 4 0 0 increases mGluR5-dependent NMDAR current, necessary for Cocaine-sensitivity, HOMER1a enables Pin1 interaction; FRMPD4 required for binding; reduced signaling prevents inflammatory pain -RPS6KB1 p70S6K EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, AGC; Protein kinase, Ser/Thr (non-receptor); Translation P23443 6198 17q23.1 human T252-p 448606 HDGTVTHtFCGTIEY Pkinase molecular association, regulation; protein conformation; phosphorylation; enzymatic activity, induced translation, altered; cell growth, inhibited; translation, inhibited ELF4(DISRUPTS); ELF3(INDUCES) 11684675; 12970779; 19864428; 21561857; 21986499; 7489717; 7545671; 9218810; 9445476 36 2 17 -RRN3 TIF1A Nucleolus; Transcription initiation complex Q9NYV6 54700 16p13.11 human S170-p 470001 KEGDVDVsDSDDEDD RRN3 activity, induced; protein stabilization; molecular association, regulation; intracellular localization cell cycle regulation; chromatin organization, altered; transcription, induced POLM(DISRUPTS); TWISTNB(DISRUPTS) DNA(INDUCES) 18559419; 24297901; 27257073 3 24 2 rDNA transcription; rRNA synthesis induced -KRT18 K18 Cytoskeletal; Nucleolus P05783 3875 12q13.13 human S31-gl 6778601 YGARPVSsAASVYAG protein degradation; phosphorylation cell motility, induced; apoptosis, inhibited; cytoskeletal reorganization 20729838; 27059955 4 1 0 K18?Gly? mutation alters protein kinase phosphorylation and promotes apoptosis in response to STZ treatment; Akt1 Thr 308 phosphorylation increased 12 h after STZ treatment in livers of mice expressing wild-type K18, but in K18?Gly? inhibits Akt1 Thr 308 phosphorylation; glycosylation promotes th the phosphorylation and activation of cell-survival kinases; maintaining the normal filament organization of keratin 18 -DEPTOR DEPTOR Apoptosis Q8TB45 64798 8q24.12 human S293-p 3897131 SSGYFSSsPTLSSSP protein degradation; molecular association, regulation carcinogenesis, induced; apoptosis, inhibited; signaling pathway regulation BTRC(INDUCES); mTOR(DISRUPTS) 19446321; 22017875; 22017877 3 5 3 PI3K-Akt signaling -Kcnj3 GIRK1 Channel, potassium; Membrane protein, integral; Membrane protein, multi-pass P63251 50599 3q21 rat S401-p 10769100 DISTKLPsKLQKITG activity, induced 19765080 2 0 0 -RPS6KA3 RSK2 EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, AGC; Protein kinase, Ser/Thr (non-receptor) P51812 6197 Xp22.12 human T577-p 450152 AENGLLMtPCYTANF Pkinase phosphorylation; enzymatic activity, induced 10980595; 36806093 10 14 180 induces phosphorylation at S227 -EGFR EGFR EC 2.7.10.1; KINASE; Kinase, protein; Membrane protein, integral; Oncoprotein; Protein kinase, TK; Protein kinase, tyrosine (receptor) P00533 1956 7p11.2 human Y998-p 452118 SPTDSNFyRALMDEE receptor internalization, induced; protein degradation; molecular association, regulation; receptor internalization, altered; phosphorylation STAT5A(INDUCES); CSK(INDUCES); SHC1(INDUCES); SHP-2(INDUCES); CBL(INDUCES); CRK(INDUCES) 16729043; 19531499; 24797263 4 29 134 -RALBP1 RALBP1 GAP; GAP, Rac/Rho Q15311 10928 18p11.22 human S509-p 3136100 FLRRQIAsEKEEIER activity, induced 16087181 1 0 0 -KRT8 K8 Cytoskeletal P05787 3856 12q13.13 human T67-p 15420556 MGGITAVtVNQSLLS Keratin_2_head cytoskeletal reorganization 27403885 1 2 1 phosphorylation reduces keratin filament length, formation of connectivity-depleted and mechanically weaker networks -JAK2 JAK2 EC 2.7.10.2; KINASE; Kinase, protein; Oncoprotein; Protein kinase, TK; Protein kinase, tyrosine (non-receptor) O60674 3717 9p24.1 human K1011-sm 31899105 DKEYYKVkEPGESPI PK_Tyr_Ser-Thr molecular association, regulation; intracellular localization GH receptor(DISRUPTS) 23581279 1 0 0 translocation into the nucleus -TRAF3 TRAF3 UBIQUITIN LIGASE; Ubiquitin conjugating system; Ubiquitin ligase Q13114 7187 14q32.32 human K154-ub 1881306700 PCVRPDCkEKVLRKD molecular association, regulation TBK1(INDUCES) 33975961 1 0 0 interaction between TRAF3 and Avibirnavirus VP3 was enhanced in KEK293T cells overexpressing K33 ubiquitin, TRAF3 K154 is necessary for VP3 to downregulate IFN-beta production -KCNJ12 KCNJ12 Membrane protein, integral; Membrane protein, multi-pass Q14500 3768 17p11.2 human S64-p 3053612 FANMDEKsQRYLADM IRK activity, inhibited 12234954 1 0 0 -Psmc1 RPT2 Protease; Proteasome complex P62192 19179 12 E|12 50.43 cM mouse Y439-p 451910 EGTPEGLyL______ protein stabilization carcinogenesis, induced; apoptosis, inhibited CP(DISRUPTS) 33603165 1 6 138 -CTCF CTCF C2H2-type zinc finger protein; Transcription factor; Tumor suppressor Q08705 396274 chicken S604-p 448302 GRKRKMRsKKEDSSD transcription, altered; cell growth, altered 11238955 1 0 1 -MAPK6 ERK3 EC 2.7.11.24; KINASE; Kinase, protein; Protein kinase, CMGC; Protein kinase, Ser/Thr (non-receptor) Q16659 5597 15q21.2 human T698-p 13830502 KSIQATLtPSAMKSS protein stabilization 20236090 1 1 0 -CLDN5 Claudin-5 Cytoskeletal; Membrane protein, integral; Membrane protein, multi-pass O00501 7122 22q11.21 human Y148-p 4122714 NIVVREFyDPSVPVS PMP22_Claudin cytoskeletal reorganization 22671590 1 1 0 -SLC9A1 NHE1 Membrane protein, integral; Membrane protein, multi-pass; Motility/polarity/chemotaxis; Transporter; Transporter, SLC family P19634 6548 1p36.11 human S729-p 3181649 ASPQSPEsVDLVNEE activity, induced apoptosis, induced 18701649 3 7 2 regulates the apoptotic alkalinizing activity of NHE1 -POLI POLI DNA repair, damage; EC 2.7.7.7; Transferase Q9UNA4 11201 18q21.2 human K345-ub 50771302 SEVEAKNkIEELLAS IMS_C protein degradation 26370087 1 2 0 -PRKN PARK2 EC 6.3.2.-; EC 6.3.2.19; Ligase; Translation; Translation regulation; UBIQUITIN LIGASE; Ubiquitin conjugating system; Ubiquitin ligase O60260 5071 6q26 human S378-p 454424 AYHEGECsAVFEASG molecular association, regulation; enzymatic activity, induced cell cycle regulation; carcinogenesis, inhibited CDC20(INDUCES) 26387737 4 1 1 important in mitosis -FOXM1 FOXM1 iso2 DNA-binding; Transcription factor Q08050-2 2305 12p13.33 human T596-p 451437 ETLPISStPSKSVLP molecular association, regulation transcription, induced CBP(INDUCES) 15024056 4 3 3 -STAT1 STAT1 DNA-binding; Transcription factor P42224 6772 2q32.2 human K652-ub 12108418 PDIIRNYkVMAAENI SH2 ubiquitination IFNAR2(DISRUPTS) 32123171 1 7 12 linear ubiquitination of K511 and K652 and inhibits interaction with INFAR2, INF-I stimulation removes STAT1 linear ubiquitination, viruses upregulate HOIP and STAT1 linear ubiquitination -AKAP4 AKAP4 Adaptor/scaffold; Cancer Testis Antigen (CTA) Q5JQC9 8852 Xp11.22 human T265-p 457176 KERISPRtPASKIAS AKAP_110 intracellular localization 27901058 1 2 0 localization to Golgi -Ric8a RIC8A GEF; GEF, misc. NP_001093990 293614 1q41 rat T440-p 468628 QYSEDEDtDTEEYRE Ric8 activity, induced; protein stabilization; molecular association, regulation; protein conformation G-alpha i1(INDUCES) 29844055; 31155309; 31300652 2 56 75 G-alpha subunit guanine nucleotide exchange; G-alpha subunit folding; Phosphorylation at S435 and T440 augment stabilization of intramolecular electrostatic interactions in RIC8A; induces GEF activity -NUSAP1 NUSAP1 Cell cycle regulation; Nucleolus Q9BXS6 51203 15q15.1 human S124-p 482179 QNHEKQEsQDLRATA cell cycle regulation 21130744 1 4 4 -Il22ra1 IL22RA1 Membrane protein, integral Q80XZ4 230828 4 D3|4 67.99 cM mouse S410-p 23115552 YAVCVEDsGKDSTPG protein stabilization 24742671 1 0 1 -DVL2 DVL2 Adaptor/scaffold; Motility/polarity/chemotaxis O14641 1856 17p13.1 human K428-ub 41486014 TDMASVTkAMAAPES molecular association, regulation; intracellular localization cell motility, induced; signaling pathway regulation Cofilin-1(INDUCES); VANGL1(INDUCES) 31340145 1 4 0 DVL2 variant with all encoded lysine residues mutated to arginine is sufficient to restore WNT activation -Fxyd1 PLM Cell surface; Channel, misc.; Membrane protein, integral O08589 58971 1q21 rat S83-p 451424 EEGTFRSsIRRLSTR activity, induced; molecular association, regulation; intracellular localization ZDHHC5(INDUCES); caveolin-3(DISRUPTS) 16434394; 19339511; 23532852; 25422474 22 20 60 -BLNK BLNK Adaptor/scaffold Q8WV28 29760 10q24.1 human S285-p 7603541 AERHRGSsHRQEAVQ molecular association, regulation 14-3-3 sigma(INDUCES); 14-3-3 zeta(INDUCES); 14-3-3 gamma(INDUCES) 33176192 1 1 0 -ABL1 Abl EC 2.7.10.2; KINASE; Kinase, protein; Oncoprotein; Protein kinase, TK; Protein kinase, tyrosine (non-receptor) P00519 25 9q34.12 human Y139-p 456712 VSRNAAEyLLSSGIN SH2 enzymatic activity, induced 18775312 2 0 57 SH2 and catalytic domains of Fes and Abl interact with ligand, stimulating kinase activity. -TJP2 ZO2 Adaptor/scaffold; Motility/polarity/chemotaxis Q95168 403854 dog S257-p 28700303 PDARHAGsRSRSREH intracellular localization 23804652 1 0 0 -Erbb2 HER2 EC 2.7.10.1; KINASE; Kinase, protein; Membrane protein, integral; Oncoprotein; Protein kinase, TK; Protein kinase, tyrosine (receptor) P06494 24337 10q31 rat Y1223-p 449744 SPAFDNLyYWDQNSS molecular association, regulation apoptosis, altered SHC1(DISRUPTS) 19826412 34 1 14 inhibits apoptosis -HTT Huntingtin Cytoskeletal P42858 3064 4p16.3 human S13-p 10206805 KLMKAFEsLKSFQQQ receptor internalization, induced; molecular association, regulation; intracellular localization; protein conformation exocytosis, inhibited; apoptosis, inhibited; cytoskeletal reorganization HMGB1(INDUCES); Huntingtin(INDUCES); Huntingtin(DISRUPTS); Exportin-1(DISRUPTS) 21623356; 23297360; 24334607; 24505464; 28698602; 30185623; 30538129; 32757223; 33256402; 35780830 19 3 0 -PDHA1 PDHA1 Amino Acid Metabolism - valine, leucine and isoleucine biosynthesis; Carbohydrate Metabolism - butanoate; Carbohydrate Metabolism - citrate (TCA) cycle; Carbohydrate Metabolism - glycolysis and gluconeogenesis; Carbohydrate Metabolism - pyruvate; EC 1.2.4.1; Mitochondrial; Oxidoreductase P08559 5160 Xp22.12 human S239-p 1870773102 SVERAAAsTDYYKRG E1_dh enzymatic activity, inhibited carcinogenesis, induced 32993545 1 0 0 -MEF2A MEF2A DNA-binding; Motility/polarity/chemotaxis; Transcription factor Q02078 4205 15q26.3 human T312-p 448097 QATQPLAtPVVSVTT activity, induced transcription, altered 10849446; 9858528 3 0 0 -Ahcyl1 AHCYL1 Amino Acid Metabolism - cysteine and methionine; EC 3.3.1.1; Hydrolase; Other Amino Acids Metabolism - selenoamino acid Q80SW1 229709 3 F2.3|3 46.83 cM mouse S71-p 467245 SRSISQSsTDSYSSA molecular association, regulation PIP4K2A(INDUCES); PIP5K1A(INDUCES); IP3R1(INDUCES) 16793548; 26509711 5 1 0 -Tie1 TIE1 EC 2.7.10.1; KINASE; Kinase, protein; Membrane protein, integral; Protein kinase, TK; Protein kinase, tyrosine (receptor) Q06806 21846 4 D2.1|4 54.67 cM mouse T794-p 50596802 LHRRRTFtYQSGSGE molecular association, regulation RAC1(INDUCES) 26436659 1 0 0 angiogenesis and vascular morphogenesis -SREBF1 SREBP-1 DNA-binding; Membrane protein, integral; Membrane protein, multi-pass; Transcription factor P36956 6720 17p11.2 human K324-ac 459100 SAQSRGEkRTAHNAI HLH protein stabilization; ubiquitination transcription, induced 12640139; 20595232 2 0 0 -Tp53 p53 Activator; DNA-binding; Motility/polarity/chemotaxis; Nuclear receptor co-regulator; Transcription factor; Tumor suppressor P02340 22059 11 B3|11 42.83 cM mouse S180-p 18675301 CPHHERCsDGDGLAP P53 molecular association, regulation cell growth, induced; transcription, inhibited DNA(DISRUPTS) 32873634 3 1 0 induced lymphomagenesis -FLI1 FLI1 DNA-binding; Oncoprotein; Transcription factor Q01543 2313 11q24.3 human K252-ac 28108001 GGAQTISkNTEQRPQ transcription, induced 22973553 1 1 0 -AURKB AurB EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, Other; Protein kinase, Ser/Thr (non-receptor) Q96GD4 9212 17p13.1 human T236-p 4164705 RRKTMCGtLDYLPPE Pkinase protein conformation; phosphorylation; enzymatic activity, induced cell cycle regulation; cytoskeletal reorganization 31819079; 34635673 2 5 16 primes autophosphorylation of itself and phosphorylation of Hec1; required for spindle assembly checkpoint -Pard3 PAR3-alpha Adaptor/scaffold; Motility/polarity/chemotaxis Q9Z340 81918 19q12 rat T833-p 2512944 QSMSEKRtKQFSNAS protein degradation; molecular association, regulation cell motility, altered; cytoskeletal reorganization PARD6A(DISRUPTS); PKCI(DISRUPTS); PKCA(DISRUPTS) 18267089; 28319357 3 0 0 -Casp4 CASP4 Apoptosis; EC 3.4.22.64; Protease P70343 12363 9 A1|9 2.46 cM mouse K312-ub 1877676801 HHLSYRDkTGGSYFI Peptidase_C14 protein degradation 30816303 1 0 0 -CIC capicua DNA-binding; Transcription factor Q96RK0 23152 19q13.2 human S301-p 478739 ETRERSMsETGTAAA molecular association, regulation; intracellular localization transcription, induced 14-3-3 theta(INDUCES) 33103082 1 4 29 -RAF1 RAF1 EC 2.7.11.1; KINASE; Kinase, protein; Oncoprotein; Protein kinase, Ser/Thr (non-receptor); Protein kinase, TKL P04049 5894 3p25.2 human S43-p 447744 FGYQRRAsDDGKLTD molecular association, regulation; intracellular localization; enzymatic activity, inhibited 14-3-3 beta(INDUCES); HRas(DISRUPTS) 12801936; 15664191; 7935389 17 23 5 -PKN1 PKN1 EC 2.7.11.13; KINASE; Kinase, protein; Protein kinase, AGC; Protein kinase, Ser/Thr (non-receptor) Q16512 5585 19p13.12 human S562-p 483683 LGTDSDSsPQKSSRD enzymatic activity, induced carcinogenesis, induced; cell motility, induced; cell growth, induced 31981797 1 30 2 induces anchorage-independent cell growth -WAS WASP Adaptor/scaffold; Motility/polarity/chemotaxis P42768 7454 Xp11.23 human S484-p 449295 RSRAIHSsDEGEDQA molecular association, regulation cytoskeletal reorganization ARPC3(INDUCES) 12769847 2 11 0 The double mutant (S483A/S484A) was used in this study. -DDX3X DDX3 Cell cycle regulation; EC 3.6.4.13; Helicase; RNA-binding; Spliceosome; Translation initiation O00571 1654 Xp11.4 human T204-p 457783 LTRYTRPtPVQKHAI DEAD enzymatic activity, inhibited translation, altered; cell growth, altered 16280325; 17379183 2 2 0 -IRF3 IRF3 DNA-binding; Transcription factor Q14653 3661 19q13.33 human K39-ub 1877340001 TRFRIPWkHGLRQDA IRF protein degradation; molecular association, regulation autophagy, induced; transcription, induced CALCOCO2(INDUCES) DNA(INDUCES) 32075857; 37330913 2 0 0 GPR108 and Smurf1 mediated degradation requires NDP52; NDP52-dependent autophagic degradation of phosphorylated IRF3; GPR108 interacts with Smurf1, followed by the recruitment of IRF3 during viral infection -TAGLN2 TAGLN2 Cytoskeletal; Motility/polarity/chemotaxis P37802 8407 1q23.2 human S83-p 19083400 PVKKIQAsTMAFKQM CH molecular association, regulation carcinogenesis, induced; cell motility, induced; cytoskeletal reorganization ACTB(DISRUPTS) 21577206 1 2 0 -Foxp3 FOXP3 C2H2-type zinc finger protein; Cell cycle regulation; DNA-binding; Transcription factor Q99JB6 20371 X A1.1|X 3.41 cM mouse K267-ac 25614401 AGKMALAkAPSVASM protein stabilization; ubiquitination cell differentiation, induced 22312127 3 1 0 inhibits ubiquitination -USP16 USP16 DEUBIQUITINASE; EC 3.4.19.12; Protease; Ubiquitin conjugating system; Ubiquitin-specific protease Q9Y5T5 10600 21q21.3 human S486-p 50592105 SEYEAEMsLQGEVNI UCH enzymatic activity, induced 26323689 1 1 0 -DPYSL2 CRMP-2 Microtubule-binding; Motility/polarity/chemotaxis Q16555 1808 8p21.2 human T555-p 448084 DNIPRRTtQRIVAPP molecular association, regulation; intracellular localization; protein conformation; phosphorylation cytoskeletal reorganization TUBA1A(DISRUPTS); KLC1(DISRUPTS) 21421798; 22443207; 29926835; 32019603 19 2 8 -Cdh5 CDH5 Cell adhesion; Membrane protein, integral; Motility/polarity/chemotaxis P55284 12562 8 D3|8 53.04 cM mouse Y645-p 2028403 IHEQLVTyDEEGGGE cell motility, altered 18096689 1 0 0 affects cell migration and increased endothelial cell barrier permeability -HNRNPC hnRNP C1/C2 RNA splicing; RNA-binding; Spliceosome P07910 3183 14q11.2 human S253-p 448835 ETNVKMEsEGGADDS molecular association, regulation RNA(NOT_REPORTED) 15687492 2 45 17 -MEF2C MEF2C iso3 DNA-binding; Transcription factor Q06413-3 4208 5q14.3 human S59-p 447999 NKLFQYAsTDMDKVL transcription, induced 26660426 2 0 0 IEG genes during preBCR signaling -TPPP TPPP Cytoskeletal O94811 11076 5p15.33 human S160-p 487536 GVTKAISsPTVSRLT p25-alpha cytoskeletal reorganization 17693641 1 11 0 ERK2 phosphorylation of TPPP induces formation of tubulin assemblies. -Fos Fos DNA-binding; Motility/polarity/chemotaxis; Oncoprotein; Transcription factor P12841 314322 6q31 rat T325-p 448483 TELEPLCtPVVTCTP activity, induced; molecular association, regulation transcription, altered DNA(INDUCES) 17223854 5 0 1 -PPARG PPAR-gamma DNA-binding; Nuclear receptor; Transcription factor P37231 5468 3p25.2 human S273-p 15175800 TGKTTDKsPFVIYDM carcinogenesis, induced; apoptosis, inhibited; transcription, induced; transcription, altered; transcription, inhibited 26670611; 26740599; 36214635; 36841479 26 2 0 -P2rx3 P2X3 Channel, ligand-gated; Membrane protein, integral; Membrane protein, multi-pass P49654 81739 3q24 rat Y393-p 9486200 QSTDSGAySIGH___ activity, inhibited 19509283 1 0 0 -APC APC Motility/polarity/chemotaxis; Tumor suppressor P25054 324 5q22.2 human S2034-p 454100 LSSLSIDsEDDLLQE SAMP intracellular localization 11689703 1 0 0 -ZAP70 ZAP70 EC 2.7.10.2; KINASE; Kinase, protein; Protein kinase, TK; Protein kinase, tyrosine (non-receptor) P43403 7535 2q11.2 human T293-p 478058 TLNSDGYtPEPARIT molecular association, regulation; activity, inhibited CD3Z(INDUCES) 29440413 1 2 10 negatively regulates signals and functional responses downstream of the TCR -Stmn2 STMN2 Cytoskeletal P55821 20257 3 A1|3 2.15 cM mouse S73-p 450173 EAPRTLAsPKKKDLS Stathmin protein degradation; activity, inhibited cell motility, altered; cytoskeletal reorganization 16618812; 21297631; 24469251 9 1 0 Phosphorylated SCG10 accumulates in THC-treated neurons after proteasomal inhibition.; phospho-mimetic S62D/S73D mutant stabilizes microtubules; inhibits microtubule depolymerization activity of STMN2 (SCG10). -IRS4 IRS4 Adaptor/scaffold O14654 8471 Xq22.3 human Y656-p 1877150800 SGGRFRLyFCVDRGA cell cycle regulation; carcinogenesis, induced; cell growth, induced 35550247 1 1 0 -CUL3 CUL3 Cell cycle regulation; UBIQUITIN LIGASE; Ubiquitin conjugating system; Ubiquitin ligase Q13618 8452 2q36.2 human K712-ne 486343 AAIVRIMkSRKKMQH Cullin_Nedd8 molecular association, regulation; ubiquitination KEAP1(INDUCES); RBX1(INDUCES); CAND1(INDUCES) 16449638 1 1 0 Neddylation of Cul3 is required for Keap1-dependent ubiquitination of Nrf2 in vivo, but not in vitro. -Clcn3 CLCN3 iso2 Channel, chloride; Membrane protein, integral; Membrane protein, multi-pass; Transporter; Transporter, ion channel; Vesicle P51792-2 84360 rat Y284-p 3577859 FSLEEVSyYFPLKTL Voltage_CLC activity, induced; molecular association, regulation apoptosis, inhibited; signaling pathway regulation ITGB3(INDUCES) 23536605; 24611720; 25537517 3 0 0 channel activation; Integrin ?3/Src/ClC-3 -EIF5 EIF5 Translation; Translation initiation P55010 1983 14q32.32 human S390-p 448030 KEAEEESsGGEEEDE W2 molecular association, regulation cell cycle regulation; translation, altered eIF2-alpha(INDUCES) 16227438; 18649047 3 53 44 -H3C1 H3 DNA-binding P68431 8350 6p22.2 human K4-m2 459004 ____ARTkQTARKST Histone molecular association, regulation; acetylation; methylation; intracellular localization cell cycle regulation; carcinogenesis, inhibited; apoptosis, induced; cell growth, inhibited; transcription, induced; transcription, altered; signaling pathway regulation; DNA repair, induced; cell differentiation, induced; chromatin organization, altered; cell growth, induced; transcription, inhibited CDC73(INDUCES); PHF23(INDUCES); PHF2(INDUCES); WDR5(INDUCES); PHF12(INDUCES); RBBP4(DISRUPTS); FALZ(INDUCES); ING4(INDUCES); TIF1G(INDUCES); CHD-7(INDUCES); SH2BP1(INDUCES); PHF21A(INDUCES); JADE3(INDUCES); MLL(INDUCES); CCDC101(INDUCES); RBBP5(INDUCES); PHF8(INDUCES); PAF(INDUCES); FALZ iso4(INDUCES); PHF14(INDUCES); RAI1(INDUCES); CHD-1(INDUCES) 15620353; 16728976; 17305432; 17310985; 17351631; 17363312; 17567990; 17636034; 17968314; 18701507; 19021773; 19187765; 19229332; 19251738; 19337993; 19460472; 19473514; 19717977; 19805358; 19885928; 19889207; 19935671; 20033197; 20043883; 20228790; 20404096; 20452361; 20473313; 20484083; 20546607; 20548336; 20850016; 20959362; 23285160; 23302691; 34853474; 35409160 108 10 0 expression of genes in clusters 8 and 9 by cooperating with H4K16ac, H3K4me2, and H3K4me3 at the transcription start sites (TSSs); H1 linker histone inhibits H3K4 dimethylation and promotes epigenetic silencing; promotes centromeric transcription and increased R-loop formation in response to DSBs; HR factors recruitment at centromeric DSBs in G1 and G2 -NFE2L2 NRF2 DNA-binding; Transcription factor Q16236 4780 2q31.2 human K543-ac 7106315 KEKLLKEkGENDKSL bZIP_Maf molecular association, regulation transcription, induced DNA(INDUCES) 19273602 1 1 0 -PTEN PTEN Carbohydrate Metabolism - inositol phosphate; EC 3.1.3.16; EC 3.1.3.48; EC 3.1.3.67; Motility/polarity/chemotaxis; Nuclear receptor co-regulator; PHOSPHATASE; Phosphatase, lipid; Tumor suppressor P60484 5728 10q23.31 human K289-sm 27490410 GPEETSEkVENGSLC PTEN_C2 molecular association, regulation; ubiquitination; intracellular localization ubiquitin(DISRUPTS) 23013792 1 0 0 SUMO 1 modification inhibits ubiquitination -MYH7 MYH7 Motility/polarity/chemotaxis; Motor P12883 4625 14q11.2 human K429-ac 1881951901 YATGALAkAVYERMF protein conformation 35502901 0 1 0 -MAPT Tau iso8 ACETYLTRANSFERASE; Acetyltransferase; Cytoskeletal P10636-8 4137 17q21.31 human K290-ac 1881568101 DLSNVQSkCGSKDNI molecular association, regulation 34426645 1 0 0 reduced tau microtuble interactions -Twist1 TWIST1 Cell development/differentiation; DNA-binding; Inhibitor; Transcription regulation P26687 22160 12 A3|12 14.81 cM mouse S127-p 14821303 RERQRTQsLNEAFAA HLH cell motility, induced; cell growth, induced 25622896 5 1 0 invasion in prostate cancer cells, cancer metastasis in vivo -UBA52-RPS27A-UBB-UBC ubiquitin Ubiquitin-like modifier P62988 2p16 human K33-ub 486302 VKAKIQDkEGIPPDQ ubiquitin molecular association, regulation; ubiquitination; intracellular localization autophagy, induced LC3B(INDUCES); TBK1(INDUCES) 33975961; 35474067; 36379251 10 15 135 BAP37 promotes ef?cient mitophagy ; downregulation by HIV-1 Nef, required for SERINC5 anti-HIV-1 activity; interaction between TRAF3 and Avibirnavirus VP3 was enhanced in KEK293T cells overexpressing K33 ubiquitin, TRAF3 K154 is necessary for VP3 to downregulate IFN-beta production -KDM5A JARID1A DEMETHYLASE; Demethylase; EC 1.14.11.-; Nuclear receptor co-regulator; Nucleolus; Oxidoreductase; Transcription factor P29375 5927 12p13.33 human T285-p 56630501 QMRQRKGtLSVNFVD intracellular localization 27292631 1 0 0 JARID1A recruitment to the promoters of AKT-regulated genes -BRCA2 BRCA2 DNA repair, damage; Nuclear receptor co-regulator; Tumor suppressor P51587 675 13q13.1 human T207-p 469578 TPPTLSStVLIVRNE molecular association, regulation; phosphorylation cell cycle regulation; cell growth, induced PPP2CA(INDUCES); BUB1(INDUCES); PLK1(INDUCES) 32286328 2 1 0 causes self priming of its phosphorylation -HNRNPC hnRNP C1/C2 RNA splicing; RNA-binding; Spliceosome P07910 3183 14q11.2 human Y57-p 2811401 KGFAFVQyVNERNAR RRM_1 molecular association, regulation RNA(INDUCES) 18494499 1 2 1 Northwestern analysis, RNA stabilization -ZBTB16 PLZF C2H2-type zinc finger protein; DNA-binding; Oncoprotein; Transcription, coactivator/corepressor Q05516 7704 11q23.2 human S197-p 2134715 SFGLSAMsPTKAAVD protein degradation cell cycle regulation; transcription, altered; cell growth, altered 18246121 1 0 0 -GLI1 GLI1 C2H2-type zinc finger protein; Oncoprotein; Transcription factor P08151 2735 12q13.3 human S408-p 41595600 GPLPRAPsISTVEPK protein degradation; molecular association, regulation; ubiquitination; intracellular localization; activity, inhibited carcinogenesis, inhibited; cell growth, inhibited; transcription, inhibited BTRC(INDUCES) 26190112; 26843621; 28562331 4 2 0 -SYK Syk EC 2.7.10.2; KINASE; Kinase, protein; Protein kinase, TK; Protein kinase, tyrosine (non-receptor) P43405 6850 9q22.2 human K375-ub 1881478400 KLLTLEDkELGSGNF molecular association, regulation; intracellular localization; protein conformation; enzymatic activity, induced SHP-1(DISRUPTS) 34362877 1 1 0 TRIM31 attenuated SHP-1 mediated WT SYK dephosphorylation; anti-fungal responses; SYK translocation to the membrane and binding with the C-type lectin receptors (CLRs) -MUS81 MUS81 Deoxyribonuclease; EC 3.1.22.-; Nucleolus Q96NY9 80198 11q13.1 human K524-sm 1872852106 ETLLSTIkCGRLQRN cell cycle regulation; DNA repair, induced 28318385 1 0 0 regulates genomic stability and chromosome alignment -Dlg1 DLG1 Adaptor/scaffold; Motility/polarity/chemotaxis Q62696 25252 11q22 rat S232-p 451615 ITLERGNsGLGFSIA PDZ molecular association, regulation neural plasticity NMDAR2A(DISRUPTS) 12933808; 17156128; 35977502 4 4 0 -GLI3 GLI3 C2H2-type zinc finger protein; Transcription factor P10071 2737 7p14.1 human K436-m1 56418600 PMHNKRSkIKPDEDL protein stabilization cell growth, induced 27146893 1 1 0 positively regulates tumorigenesis in NSCLCs -ORAI1 ORAI1 Channel, calcium; Membrane protein, integral; Membrane protein, multi-pass Q96D31 84876 12q24.31 human S30-p 14932000 TTSGSRRsRRRSGDG activity, induced; molecular association, regulation; intracellular localization; activity, inhibited cell growth, inhibited; cell motility, inhibited IP3R2(INDUCES) 20534587; 23144458; 31652779; 35805121 5 0 0 -Grm5 mGluR5 GPCR, family 3; Membrane protein, integral; Membrane protein, multi-pass; Receptor, GPCR Q3UVX5 108071 7|7 D3 mouse S870-p 25745197 NLWKRRGsSGETLRY signaling pathway regulation 25639954 1 1 1 required for activation of ERK signaling and intracellular Ca2+ oscillations -RET Ret EC 2.7.10.1; KINASE; Kinase, protein; Membrane protein, integral; Oncoprotein; Protein kinase, TK; Protein kinase, tyrosine (receptor) P07949 5979 10q11.21 human T675-p 22553316 PISSAEMtFRRPAQA intracellular localization signaling pathway regulation 22128160 1 0 0 modulates GDNF-induced downstream signaling and cell differentiation -Maf MAF Cell development/differentiation; DNA-binding; Oncoprotein; Transcription factor; Tumor suppressor P54843 17132 8 E1|8 62.61 cM mouse Y92-p 25673105 KAHLEDYyWMTGYPQ Maf_N molecular association, regulation transcription, induced DNA(INDUCES) 25993510 2 0 0 IL-4 and IL-21 induction -Tp53 p53 Activator; DNA-binding; Motility/polarity/chemotaxis; Nuclear receptor co-regulator; Transcription factor; Tumor suppressor P02340 22059 11 B3|11 42.83 cM mouse K161-ac 2793003 VRAMAIYkKSQHMTE P53 cell cycle regulation; carcinogenesis, inhibited; apoptosis, induced; transcription, induced 33303641; 33789902 12 1 0 recruit p300, CBP, and TIP60 onto PD-1 promoter, p53-mediated PD-1 transcription; senescence, ferroptosis, failed to develop early-onset tumors -PDGFRA PDGFRA EC 2.7.10.1; KINASE; Kinase, protein; Membrane protein, integral; Oncoprotein; Protein kinase, TK; Protein kinase, tyrosine (receptor) P16234 5156 4q12 human Y720-p 452056 ADESTRSyVILSFEN PK_Tyr_Ser-Thr molecular association, regulation SHP-2(INDUCES) 11818394; 11896619; 8943348 6 3 2 Grb2 binds to the PDGFRalpha indirectly via tyrosine-phosphorylated SHP-2. -FERMT2 kindlin-2 Cytoskeletal; Motility/polarity/chemotaxis Q96AC1 10979 14q22.1 human S159-p 3208605 KKKLDDQsEDEALEL carcinogenesis, induced; cytoskeletal reorganization 25646088; 32104508 2 37 5 regulates invadopodia formation; induces invadopodia formation -CCP110 CP110 Cell cycle regulation O43303 9738 16p12.3 human S400-p 4744475 PINACELsPKGKEQA intracellular localization cell cycle regulation 12361598 1 10 36 -MYO3A MYO3A Actin-binding; EC 2.7.11.1; KINASE; Kinase, protein; Motor; Protein kinase, STE; Protein kinase, Ser/Thr (non-receptor) Q8NEV4 53904 10p12.1 human T178-p 23252211 VSAQLTStRHRRNTS Pkinase enzymatic activity, induced 24214986; 25402663 2 2 1 -TPM1 TPM1 Actin-binding; Motility/polarity/chemotaxis; Motor P09493 7168 15q22.2 human S61-p 456510 EDELDKYsEALKDAQ Tropomyosin intracellular localization 16094730 1 5 6 phosphorylation of site is critical for agonist-stimulated beta-adrenergic receptor endocytosis. -CFLAR CFLAR iso2 Apoptosis O15519-2 8837 2q33.1 human S193-p 7590803 LQAAIQKsLKDPSNN protein stabilization; ubiquitination 19343040 1 2 0 -FBXW7 FBXW7 Motility/polarity/chemotaxis; Nucleolus; UBIQUITIN LIGASE; Ubiquitin conjugating system; Ubiquitin ligase Q969H0 55294 4q31.3 human S176-p 25126709 KRKLDHGsEVRSFSL protein degradation; molecular association, regulation cytoskeletal reorganization Myc(INDUCES) 22399798; 34992218 2 1 0 Phosphorylation prevents ubiquitin-dependent degradation of cyclin E and subsequent centriole duplication. -MAT2A MAT2A Amino Acid Metabolism - cysteine and methionine; EC 2.5.1.6; Other Amino Acids Metabolism - selenoamino acid; Transferase P31153 4144 2p11.2 human K368-sm 50455001 VRDLDLKkPIYQRTA S-AdoMet_synt_C protein stabilization; molecular association, regulation cell growth, induced; apoptosis, inhibited; transcription, induced Bcl-2(INDUCES) DNA(INDUCES) 26416353 1 0 0 -FOXO4 FOXO4 DNA-binding; Oncoprotein; Transcription factor P98177 4303 Xq13.1 human S197-p 448516 APRRRAAsMDSSSKL intracellular localization apoptosis, altered; transcription, inhibited 10217147; 11313479; 16272144; 18794113 13 5 6 -Stx1a STX1A Membrane protein, integral; Vesicle P32851 116470 12q12 rat S14-p 451261 ELRTAKDsDDDDDVT molecular association, regulation exocytosis, altered; signaling pathway regulation; endocytosis, inhibited SNAP-25(INDUCES) 10844023; 21187092; 30411139; 32852799 7 22 4 -FYN Fyn EC 2.7.10.2; KINASE; Kinase, protein; Oncoprotein; Protein kinase, TK; Protein kinase, tyrosine (non-receptor) P06241 2534 6q21 human S21-p 1983273 LTEERDGsLNQSSGY intracellular localization; phosphorylation; enzymatic activity, induced cell motility, altered 20658524 1 38 12 -GPR84 GPR84 GPCR, family 1; Membrane protein, integral; Membrane protein, multi-pass; Motility/polarity/chemotaxis; Receptor, GPCR Q9NQS5 53831 12q13.13 human T264-p 1876864000 EPVSAATtQTLEGDS 7tm_1 receptor internalization, induced; molecular association, regulation ARR3(INDUCES); ARRB2(INDUCES) 35427647 1 1 0 -GRK2 GRK2 EC 2.7.11.15; KINASE; Kinase, protein; Protein kinase, AGC; Protein kinase, Ser/Thr (non-receptor) P25098 156 11q13.2 human S29-p 447724 ATPAARAsKKILLPE activity, induced 11042191 2 0 0 -CYCS CYCS Apoptosis; Mitochondrial; Oxidoreductase; PHOSPHATASE; Protein phosphatase, Ser/Thr (non-receptor) P99999 54205 7p15.3 human K54-ac 1968625 YSYTAANkNKGIIWG Cytochrom_C molecular association, regulation; enzymatic activity, inhibited; protein conformation apoptosis, inhibited 33916826; 34455704 2 2 0 reduced cytochrome c oxidase and caspase 3 activity, reduced cardiolipin peroxidase activity, reduced oxygen consumption with acetylmimetic Cytc as compared to WT, increased ROS scavenging ; loss of positive potential at the surface areas around the mutated residue, thermal stability of Cc species is slightly changed, local structural changes, and increased binding afinity for the Cc1-Cc complex for the K8 mutants -Ces1d CES1D EC 3.1.1.1; EC 3.1.1.67 P16303 113902 19p11 rat N506-p 3540200 ANFARNGnPNGGGLP COesterase enzymatic activity, induced 11429416 2 0 0 mutation to serine selectively stimulated hydrolysis but was not sufficient to confer cholesteryl esterase activity. -Skap2 SKAP2 Adaptor/scaffold Q3UND0 54353 6|6 B3 mouse Y260-p 449668 QPIDDEIyEELPEEE molecular association, regulation cell motility, induced; cell growth, altered LYN(INDUCES); Hck(INDUCES); Fyn(INDUCES) 11063873; 23897807 5 8 100 -Stat3 STAT3 DNA-binding; Motility/polarity/chemotaxis; Nuclear receptor co-regulator; Transcription factor P42227 20848 11 D|11 63.82 cM mouse K370-ac 41519931 KIKVCIDkDSGDVAA STAT_bind molecular association, regulation transcription, induced; signaling pathway regulation NFkB-p65(INDUCES) 28637784 1 1 0 signaling to improve mitochondrial fusion and function; K383 may induce stronger binding, enhanced OPA1 expression -Ctnnd1 CTNND1 Actin-binding; Adaptor/scaffold; Cell adhesion; G protein regulator, misc.; Motility/polarity/chemotaxis P30999 12388 2 D|2 49.45 cM mouse Y280-p 450398 HRFHPEPyGLEDDQR cell cycle regulation; cell motility, altered 18515860 2 18 210 -Actn4 ACTN4 Cytoskeletal; Motility/polarity/chemotaxis P57780 60595 7|7 B1 mouse Y32-p 11498502 GGGSMGDyMAQEDDW cytoskeletal reorganization 33532643 5 1 0 decreased binding to actin filaments has been observed after phosphorylation of this site -STAP2 STAP2 Adaptor/scaffold Q9UGK3 55620 19p13.3 human Y322-p 3974222 GDGPAVDyENQDVAS molecular association, regulation transcription, altered STAT3(INDUCES) 12540842 1 1 6 -ESR1 ER-alpha DNA-binding; Nuclear receptor; Transcription factor P03372 2099 6q25.1-q25.2 human S167-p 448102 GGRERLAsTNDKGSM Oest_recep activity, induced; acetylation; molecular association, regulation; phosphorylation carcinogenesis, induced; cell growth, induced; apoptosis, inhibited; transcription, induced; signaling pathway regulation; transcription, altered; cell growth, altered SRC-3(INDUCES) DNA(NOT_REPORTED) 11108261; 11139588; 11432835; 11507039; 15528270; 15778291; 16455819; 19112174; 19887647; 19940156; 23390529; 23861392; 24166501; 31120927; 33542078; 34810200; 35121200; 36915147; 9337862; 9528769 48 6 0 -PKP1 plakophilin 1 Cell adhesion; Motility/polarity/chemotaxis Q13835 5317 1q32.1 human T166-p 15405306 LYCDPRGtLRKGTLG activity, induced; protein stabilization cell motility, induced; cell growth, induced; translation, induced; cell adhesion, inhibited 23444369 1 2 34 -USP11 USP11 DEUBIQUITINASE; EC 3.4.19.12; Protease; Ubiquitin conjugating system; Ubiquitin-specific protease P51784 8237 Xp11.3 human S948-p 466974 GSSGAPAsPACSSPP ubiquitination; intracellular localization carcinogenesis, induced; cell growth, induced 35414784 1 11 14 induces deubiquitination of p21 -Ahr AHR DNA-binding; Transcription factor P41738 25690 6q16 rat T385-p 3798901 IATQRPLtDEEGREH transcription, altered 15451023 1 0 0 -EMD emerin Cytoskeletal; Membrane protein, integral P50402 2010 Xq28 human S175-p 457527 RPVSASRsSLDLSYY molecular association, regulation BAF(DISRUPTS) 16204256 1 5 0 -BMAL1 BMAL1 DNA-binding; Transcription factor O00327 406 11p15.3 human S183-p 1884110700 VFKILNYsQNDLIGQ molecular association, regulation; intracellular localization carcinogenesis, induced; DNA repair, induced; apoptosis, inhibited CLOCK(INDUCES) 36725890 1 0 0 -Vim Vimentin Cytoskeletal; Motility/polarity/chemotaxis P20152 22352 2 A1|2 10.04 cM mouse S39-p 451766 TTSTRTYsLGSALRP Filament_head intracellular localization cell motility, altered; cytoskeletal reorganization 12458200; 21346197; 35656400 31 52 30 -XRN2 XRN2 Cell development/differentiation; EC 3.1.13.-; Nucleolus; RNA processing; RNA-binding; Ribonuclease Q9H0D6 22803 20p11.22 human T439-p 3211959 FTPSGILtPHALGSR XRN_M molecular association, regulation; enzymatic activity, induced transcription, inhibited DNA(INDUCES) 26728557 2 16 7 -LRRK2 LRRK2 EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, Ser/Thr (non-receptor); Protein kinase, TKL Q5S007 120892 12q12 human T1348-p 10426320 GNTGSGKtTLLQQLM Roc molecular association, regulation; protein conformation 21806997; 21858031 5 3 0 induces protein destabilization due to unfavourable conformation; GTP binding, does not play a modulatory role on LRRK2 kinase activity -PRKAA1 AMPKA1 Autophagy; EC 2.7.11.1; EC 2.7.11.26; EC 2.7.11.27; EC 2.7.11.31; KINASE; Kinase, protein; Protein kinase, CAMK; Protein kinase, Ser/Thr (non-receptor) Q13131 5562 5p13.1 human K285-ub 21128824 WFKQDLPkYLFPEDP enzymatic activity, inhibited 31996460 1 2 0 -GP1BA GPIbA Cell adhesion; Cell surface; Membrane protein, integral P07359 2811 17p13.2 human S629-p 1983276 LVAGRRPsALSQGRG molecular association, regulation 14-3-3 sigma(INDUCES); 14-3-3 zeta(INDUCES); PIK3R1(INDUCES) 18299448; 19874472 3 10 17 -SIAH1 SIAH1 Apoptosis; Cell development/differentiation; EC 6.3.2.-; EC 6.3.2.19; Ligase; Motility/polarity/chemotaxis; UBIQUITIN LIGASE; Ubiquitin conjugating system; Ubiquitin ligase Q8IUQ4 6477 16q12.1 human Y126-p 457102 ELCEFRPySCPCPGA Sina protein stabilization apoptosis, altered 16230351 1 0 0 -PSRC1 PSRC1 Q6PGN9 84722 1p13.3 human S22-p 18912817 TLDFGGLsPSDSREE GTSE1_N cytoskeletal reorganization 21473853 1 3 0 -MAPK3 ERK1 EC 2.7.11.24; KINASE; Kinase, protein; Protein kinase, CMGC; Protein kinase, Ser/Thr (non-receptor) P27361 5595 16p11.2 human K361-m3 52477003 DLPKERLkELIFQET enzymatic activity, induced transcription, induced 26586479 1 1 0 SUV420H1 siRNA inhibits ERK expression -Camk2b CAMK2B EC 2.7.11.17; KINASE; Kinase, protein; Protein kinase, CAMK; Protein kinase, Ser/Thr (non-receptor) P28652 12323 11 A1|11 3.89 cM mouse S182-p 18007574 AGTPGYLsPEVLRKE Pkinase enzymatic activity, inhibited 36194579 1 0 1 -RUNX1 AML1 DNA-binding; Oncoprotein; Transcription factor Q01196 861 21q22.12 human T207-p 34551130 ELEQLRRtAMRVSPH molecular association, regulation; methylation; intracellular localization carcinogenesis, induced; transcription, induced HDAC1(DISRUPTS); SIN3A(DISRUPTS); PRMT1(INDUCES) 32549768 1 1 1 induce osteolytic bone destruction -HSF1 HSF1 DNA-binding; Transcription factor Q00613 3297 8q24.3 human S320-p 3849409 ASPGRPSsVDTLLSP Vert_HS_TF activity, induced; protein stabilization; molecular association, regulation; intracellular localization carcinogenesis, induced; apoptosis, inhibited; transcription, induced; transcription, inhibited p300(INDUCES) 21085490; 22216146; 25963659; 31516744; 33268814 8 6 1 -GCK GK Carbohydrate Metabolism - amino sugar and nucleotide sugar; Carbohydrate Metabolism - galactose; Carbohydrate Metabolism - glycolysis and gluconeogenesis; Carbohydrate Metabolism - starch and sucrose; EC 2.7.1.2; Kinase, other; Mitochondrial P35557 2645 7p13 human K161-sm 27581519 VRHEDIDkGILLNWT Hexokinase_1 protein stabilization; enzymatic activity, induced 23297408 1 1 0 -P2ry2 P2Y2 GPCR, family 1; Membrane protein, integral; Membrane protein, multi-pass; Receptor, GPCR; Receptor, misc. P41232 29597 1q32 rat S242-p 2909200 LPRAKRKsVRTIALV 7tm_1 receptor internalization, induced 31289122 2 0 0 Regulates ATP induced calcium response -PGD PGD Carbohydrate Metabolism - pentose phosphate pathway; EC 1.1.1.44; Other Amino Acids Metabolism - glutathione; Oxidoreductase P52209 5226 1p36.22 human Y481-p 465221 GTVSSSSyNA_____ enzymatic activity, induced carcinogenesis, induced; cell growth, induced; transcription, induced 30824700 1 1 45 phosphorylation of this site increases NADP+ binding affinity of 6PGD; required for ROS detoxification and tumor cell survival upon IR treatment ; promotes DNA synthesis -JADE1 JADE1 Tumor suppressor Q6IE81 79960 4q28.2 human S20-p 35530401 SDDNGSLsTTWSQNS EPL1 protein stabilization; activity, inhibited cell differentiation, induced; transcription, induced; signaling pathway regulation 25100726 1 1 0 impairs the ability of Jade-1S to inhibit Wnt reporter activity; Decrease the ability of Jade-1 to inhibit ?-catenin signaling -Irs2 IRS2 Adaptor/scaffold; Motility/polarity/chemotaxis P81122 384783 8 A1.1|8 5.35 cM mouse S924-p 28758700 GEAGTRLsPPAPPLL activity, inhibited 23901139 1 2 0 -KLF8 KLF8 C2H2-type zinc finger protein; DNA-binding; Transcription factor O95600 11279 Xp11.21 human K95-ac 25344506 DLSFHKPkAPLQPAS sumoylation; molecular association, regulation cell cycle regulation; transcription, inhibited CTBP1(DISRUPTS) 21416054 1 1 0 inhibits sumoylation at KLF8-K67 -PRPS2 PRPS2 Carbohydrate Metabolism - pentose phosphate pathway; EC 2.7.6.1; Kinase, other; Nucleotide Metabolism - purine P11908 5634 Xp22.2 human T228-p 1874512700 DMADTCGtICHAADK Pribosyl_synth molecular association, regulation; enzymatic activity, induced DNA repair, induced; cell growth, induced Other(NOT_REPORTED) 34343500 1 1 0 inhibits ADP binding -Cbx5 HP1 alpha Transcription, coactivator/corepressor Q61686 12419 15|15 F3 mouse S12-p 3190486 TKRTADSsSSEDEEE molecular association, regulation H3(INDUCES) DNA(INDUCES) 21245376 1 29 1 important for chromosomal stability -Ctnnd1 CTNND1 Actin-binding; Adaptor/scaffold; Cell adhesion; G protein regulator, misc.; Motility/polarity/chemotaxis P30999 12388 2 D|2 49.45 cM mouse K623-ac 15292745 ASCFGAKkGKDEWFS cytoskeletal reorganization 16916647 0 1 1 -DLX3 DLX3 DNA-binding; Transcription factor O60479 1747 17q21.33 human S10-p 25736077 GSFDRKLsSILTDIS protein stabilization; molecular association, regulation cell differentiation, induced; transcription, induced DNA(INDUCES) 24924519 1 0 1 -IKZF1 Ikaros C2H2-type zinc finger protein; DNA-binding; Transcription factor Q13422 10320 7p12.2 human K58-sm 3609102 RVVASNVkVETQSDE carcinogenesis, induced; cell growth, induced 27315244 2 0 0 -Ptk2b Pyk2 EC 2.7.10.2; KINASE; Kinase, protein; Nuclear receptor co-regulator; Protein kinase, TK; Protein kinase, tyrosine (non-receptor) P70600 50646 15p12 rat Y580-p 447957 YIEDEDYyKASVTRL PK_Tyr_Ser-Thr enzymatic activity, induced 11337490 16 25 970 -Ppp2r5d PPP2R5D Motility/polarity/chemotaxis; PHOSPHATASE; Protein phosphatase, regulatory subunit Q7TNL5 21770 17 22.9 cM|17 C mouse S53-p 457388 PSSNKRPsNSTPPPT enzymatic activity, induced 20106966 5 0 0 -DDIT3 DDIT3 Autophagy; DNA-binding; Oncoprotein; Transcription factor P35638 1649 12q13.3 human S15-p 455502 FSFGTLSsWELEAWY activity, inhibited transcription, inhibited 12876286 1 0 0 -Spi1 PU.1 DNA-binding; Oncoprotein; Transcription factor P17433 20375 2 E1|2 50.44 cM mouse S148-p 455900 QSPPLEVsDGEADGL activity, induced; molecular association, regulation RNA splicing, altered; transcription, induced; transcription, altered IRF4(INDUCES); IRF8(INDUCES); PIP(INDUCES); PU.1(INDUCES); IRF8(NOT_REPORTED); IRF2(INDUCES) DNA(INDUCES) 14966110; 17200120; 20190819; 7797077; 8456286 6 4 0 -MCM4 MCM4 DNA replication; EC 3.6.4.12 P33991 4173 8q11.21 human S32-p 450001 RSEDARSsPSQRRRG activity, inhibited 12714602 2 13 9 -MOB1B MOB1B Activator; Protein kinase, regulatory subunit Q7L9L4 92597 4q13.3 human T35-p 3545001 LLKHAEAtLGSGNLR Mob1_phocein molecular association, regulation; phosphorylation cell cycle regulation; cell growth, altered NDR1(INDUCES); NDR2(INDUCES); LATS1(INDUCES); LATS2(INDUCES) 18328708; 19919647 3 47 34 -MACC1 MACC1 Q6ZN28 346389 7p21.1 human Y695-p 1874020220 KESEKVSyVIKKLKE carcinogenesis, induced; cell motility, induced; cell growth, induced; transcription, induced 34247190 1 1 0 -Ctnnb1 CTNNB1 Actin-binding; Cell adhesion; Motility/polarity/chemotaxis; Nuclear receptor co-regulator; Oncoprotein; Transcription factor Q02248 12387 9 F4|9 72.19 cM mouse S47-p 34606438 TTTAPSLsGKGNPEE intracellular localization cell cycle regulation; cytoskeletal reorganization; signaling pathway regulation PCM-1(INDUCES); CEP290(INDUCES); CEP170(INDUCES); AZI2(INDUCES) 32023461 1 1 1 induces localization of centriolar satellites, induces primary ciliogenesis through the primary ciliogenesis signaling pathway -EGFR EGFR EC 2.7.10.1; KINASE; Kinase, protein; Membrane protein, integral; Oncoprotein; Protein kinase, TK; Protein kinase, tyrosine (receptor) P00533 1956 7p11.2 human S1026-p 451640 PQQGFFSsPSTSRTP activity, inhibited 8360196 1 7 0 -CLTC CLTC Motility/polarity/chemotaxis; Vesicle Q00610 1213 17q23.1 human T606-p 1868832801 ILGNQMFtHYDRAHI Clathrin intracellular localization; phosphorylation cell cycle regulation; carcinogenesis, induced; cell growth, induced 31272276 1 0 0 induces phosphorylation of Kiz -RPS6 S6 Translation P62753 6194 9p22.1 human S236-p 448093 AKRRRLSsLRASTSK activity, induced; molecular association, regulation; enzymatic activity, induced cell cycle regulation; carcinogenesis, induced; carcinogenesis, inhibited; apoptosis, induced; cell motility, induced; signaling pathway regulation; cell growth, induced; apoptosis, inhibited RNA(INDUCES) 17360704; 20008839; 21601007; 21750219; 25738361; 34273354; 34523696; 35596155; 35998013; 36216931; 36409827; 36460969; 36635496; 36715448 239 72 1124 -TNKS TNKS EC 2.4.2.30; Transferase O95271 8658 8p23.1 human T1128-p 21326701 VEEEMQStIREHRDG PARP protein stabilization; intracellular localization; enzymatic activity, induced cell cycle regulation; cell growth, induced 21818122 1 0 0 -POLI POLI DNA repair, damage; EC 2.7.7.7; Transferase Q9UNA4 11201 18q21.2 human K334-ub 21181894 FSEEDSFkKCSSEVE IMS_C protein degradation 26370087 1 3 0 -CHEK1 Chk1 EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, CAMK; Protein kinase, Ser/Thr (non-receptor); Tumor suppressor O14757 1111 11q24.2 human K132-ub 31914110 GITHRDIkPENLLLD Pkinase phosphorylation; enzymatic activity, induced DNA(INDUCES) 32357935 3 3 0 ubiquitination at K132 by TRAF4 is required for phosphorylation and activation, and Chk1 chromatin association -Tcf3 E2A Cell development/differentiation; DNA-binding; Oncoprotein; Transcription factor P15806 21423 10 C1|10 39.72 cM mouse S140-p 455905 LSSPGPLsPSGIKSS molecular association, regulation cell differentiation, altered; transcription, altered MyoD(INDUCES) 15719023 3 9 0 -DAXX DAXX Apoptosis; Nuclear receptor co-regulator; Nucleolus; Transcription, coactivator/corepressor Q9UER7 1616 6p21.32 human K122-ub 11998602 RARSRPAkLYVYINE Daxx phosphorylation apoptosis, induced 19789334 1 0 0 induces JNK phosphorylation/activation -CD274 PD-L1 Membrane protein, integral Q9NZQ7 29126 9p24.1 human T210-p 1874101910 TNEIFYCtFRRLDPE C2-set_2 O-GlcNAc glycosylation; protein stabilization; ubiquitination carcinogenesis, induced 34315872 1 0 0 inhibits ubiquitination -NPM1 NPM1 Nucleolus; Oncoprotein; RNA-binding; Translation P06748 4869 5q35.1 human K257-ac 3284526 KMQASIEkGGSLPKV NPM1-C molecular association, regulation; intracellular localization transcription, altered H3(INDUCES) 19581289 1 6 1 K212/215/229/230/257/267/292R mutant -MC2R MC2R GPCR, family 1; Membrane protein, integral; Membrane protein, multi-pass; Receptor, GPCR Q01718 4158 18p11.21 human S208-p 456021 RSHTRKIsTLPRANM 7tm_1 receptor desensitization, altered 12456795 1 0 0 -SMN1 SMN RNA processing; RNA-binding Q16637 6606 5q13.2 human S31-p 454889 GTGQSDDsDIWDDTA SMN activity, induced; molecular association, regulation; intracellular localization coilin(INDUCES); SMN(INDUCES) 15592453; 20878088; 24602413 3 67 26 -PRKDC DNAPK DNA repair, damage; EC 2.7.11.1; KINASE; Kinase, protein; Nucleolus; Protein kinase, Ser/Thr (non-receptor); Protein kinase, atypical P78527 5591 8q11.21 human S2041-p 33365502 STLSEEMsQFDFSTG DNAPKcs_CC3 molecular association, regulation DNA repair, inhibited DNA(INDUCES) 24687855 1 0 0 induces c-NHEJ, restricts end processing -ZFP36L1 BRF1 Transcription factor Q07352 677 14q24.1 human S334-p 7997096 LPIFSRLsISDD___ activity, induced; protein stabilization cell cycle regulation; carcinogenesis, inhibited; cell growth, inhibited; cell motility, inhibited; RNA stability, inhibited; transcription, inhibited; cell adhesion, inhibited DCP1A(INDUCES) 27708140; 30914800 2 26 3 R9-ZnC S334D (aka BRF1) decreases pro-angiogenic and pro-in?ammatory cytokines, as well as EMT marker; enhances VEGF mRNA decay -LIPE HSL EC 3.1.1.79; Lipase Q05469 3991 19q13.2 human S853-p 448803 IAEPMRRsVSEAALA enzymatic activity, induced 19018281 41 11 2 -Dlx5 DLX5 DNA-binding; Transcription factor P70396 13395 6 A1|6 2.83 cM mouse S34-p 1725302 MHHPSQEsPTLPESS DLL_N transcription, induced 18056716 1 0 0 measured by Osx mRNA levels -SMN1 SMN RNA processing; RNA-binding Q16637 6606 5q13.2 human S4-p 7446258 ____MAMsSGGSGGG molecular association, regulation; intracellular localization coilin(INDUCES) 24602413 2 14 0 -Mef2c MEF2C DNA-binding; Transcription factor Q8CFN5 17260 13 C3|13 43.68 cM mouse S222-p 474086 GYGNPRNsPGLLVSP cell cycle regulation; apoptosis, inhibited 29431698 1 33 1 enhanced maintenance of leukemia stem cells -HSF1 HSF1 DNA-binding; Transcription factor Q00613 3297 8q24.3 human T367-p 469241 RPPSPPPtSTPEKCL Vert_HS_TF transcription, inhibited 25963659 1 8 18 under non-stressed conditions, upon heat shock S to A mutant showed 60% higher luciferase activity -SUPT5H SPT5 RNA-binding; Transcription, coactivator/corepressor O00267 6829 19q13.2 human S782-p 4948434 TPMYGSGsRTPMYGS transcription, induced 10757782 1 1 2 -PTH1R PTHR GPCR, family 2; Membrane protein, integral; Membrane protein, multi-pass; Receptor, GPCR Q03431 5745 3p21.31 human S492-p 2853102 RKARSGSsSYSYGPM receptor internalization, induced; molecular association, regulation ARR3(INDUCES) 27623777 4 2 1 S503 AND T504 IN THE SECOND CLUSTER ARE RESPONSIBLE FOR 70% OF ARRESTIN3 RECRUITMENT -LOC100009479 Kv1.2 Channel, potassium; Membrane protein, integral; Membrane protein, multi-pass NP_001076191 100009479 rabbit S449-p 1818102 PDLKKSRsASTISKS activity, induced 19389710 2 3 1 -MAPT Tau iso8 ACETYLTRANSFERASE; Acetyltransferase; Cytoskeletal P10636-8 4137 17q21.31 human T245-p 487534 SAKSRLQtAPVPMPD Tubulin-binding molecular association, regulation 21204788 3 2 0 in vitro microtubule binding -RBL1 Rb-like 1 Transcription, coactivator/corepressor; Tumor suppressor P28749 5933 20q11.23 human S650-p 455534 SVHERYSsPTAGSAK molecular association, regulation E2F4(DISRUPTS) 12006580 3 3 1 -BLM BLM DNA repair, damage; DNA replication; EC 3.6.4.12; Helicase P54132 641 15q26.1 human T122-p 450959 PKEVVCTtQNTPTVK BLM_N protein conformation cell cycle regulation; apoptosis, inhibited 12034743; 14729972; 16880735 5 1 0 In cells expressing BLM T99A/T122A after HU release, entrance into G1 phase was delayed, with p-Chk-1 levels remaining elevated. ; radiosensitivity -Cttn Cortactin Actin-binding; Cytoskeletal; Motility/polarity/chemotaxis Q60598 13043 7|7 F5 mouse K171-ac 15291781 VQADRVDkSAVGFDY HS1_rep molecular association, regulation; acetylation; intracellular localization DIP2A(INDUCES) 31600191 1 0 2 DIP2A regulates spine morphology and synaptic transmission through acetylation of cortactin; Interaction of DIP2A-cortactin is required for acetylated cortactin; acetylation mimetic cortactin rescues the repetitive behaviors in Dip2a KO mice; acetylation alleviated abnormal PSD95 clustering at the spine head in DIP2A KO neurons -CLDN7 Claudin-7 Cell adhesion; Membrane protein, integral; Membrane protein, multi-pass O95471 1366 17p13.1 human S204-p 27732000 VPRSYPKsNSSKEYV apoptosis, induced 23433123 1 1 0 increased sensitivity to cisplatin -Fosb FosB DNA-binding; Transcription factor P13346 14282 7 A3|7 9.56 cM mouse S27-p 465535 SAESQYLsSVDSFGS protein stabilization neural plasticity 19041372; 23467346 4 1 0 -Ptpn1 PTP1B EC 3.1.3.48; Motility/polarity/chemotaxis; PHOSPHATASE; Phosphatase; Protein phosphatase, tyrosine (non-receptor) P35821 19246 2|2 H3 mouse S50-p 447811 RNRYRDVsPFDHSRI Y_phosphatase phosphorylation; enzymatic activity, induced carcinogenesis, induced; apoptosis, inhibited 37000627 5 18 17 dephosphorylates CD3Z -Polr2a POLR2A EC 2.7.7.48; EC 2.7.7.6; Nucleotide Metabolism - purine; Nucleotide Metabolism - pyrimidine; Transcription initiation complex; Transferase P08775 20020 11 B3|11 42.86 cM mouse S1619-p 447616 SPSYSPTsPSYSPTS RNA_pol_Rpb1_R protein degradation; molecular association, regulation; ubiquitination; intracellular localization; enzymatic activity, inhibited; phosphorylation; enzymatic activity, induced transcription, induced; transcription, altered SETD1B(INDUCES); SETD2(INDUCES); SETD1A(INDUCES); TCEB3(INDUCES) 17535807; 18037880; 19037258; 21385826; 21639898; 28423325; 28768201 81 4 0 S1619 phosphorylation of the CTD at the beginning of activation; deletion of MNAT reduces S1619 phosphorylation and defective capping and reduced S1616 phosphorylation and defect in Pol II transcription; low level transcription of bivalent genes -AGER RAGE Cell cycle regulation; Membrane protein, integral; Motility/polarity/chemotaxis; Receptor, misc. Q15109 177 6p21.32 human K374-ub 1873037702 QRRGEERkAPENQEE protein degradation; phosphorylation 28515150 1 0 0 degradation by RAGE phosphorylation by PKCZ and FBXO10-directed ubiquitination -STK38 NDR1 EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, AGC; Protein kinase, Ser/Thr (non-receptor) Q15208 11329 6p21.31 human T282-p 4767540 RRQLAFStVGTPDYI Pkinase activity, induced signaling pathway regulation 31679687 1 0 12 in glucose starvation -KIF2B KIF2B Microtubule-binding; Motor Q8N4N8 84643 17q22 human S616-p 25247526 TTISGKGsSQWLENI intracellular localization cell cycle regulation 22535524 1 1 0 -Casp4 CASP4 Apoptosis; EC 3.4.22.64; Protease P70343 12363 9 A1|9 2.46 cM mouse K172-ub 1877676804 LGYDVVVkEELTAEG Peptidase_C14 protein degradation 30816303 1 0 0 -ITGB3 ITGB3 Cell adhesion; Membrane protein, integral; Motility/polarity/chemotaxis P05106 3690 17q21.32 human Y773-p 448012 DTANNPLyKEATSTF Integrin_b_cyt activity, induced; molecular association, regulation; intracellular localization; protein processing; protein conformation; activity, inhibited cell adhesion, induced; cell motility, altered; cytoskeletal reorganization; cell adhesion, altered Pyk2(INDUCES); GRB2(INDUCES); PVR(DISRUPTS); talin 1(DISRUPTS); tensin 1 iso1(INDUCES); DOK1(INDUCES); VAV1(INDUCES) 10330414; 11723131; 14996908; 15695828; 15699036; 16935858; 17473008; 18156175; 18364349; 21956114; 8631894 22 10 95 -MYH10 MYH10 Motility/polarity/chemotaxis; Motor P35580 4628 17p13.1 human T1847-p 1874404500 ANKLVRRtEKKLKEI Myosin_tail_1 molecular association, regulation; intracellular localization cell cycle regulation MYH10(DISRUPTS); Survivin(DISRUPTS) 34343568 1 0 0 -PGR PR DNA-binding; Nuclear receptor; Transcription factor P06401 5241 11q22.1 human S102-p 450158 GAGGSSSsPPEKDSG Prog_receptor transcription, induced 8662865 2 1 0 -DPYSL2 CRMP-2 Microtubule-binding; Motility/polarity/chemotaxis Q16555 1808 8p21.2 human Y479-p 18833900 KPFPDFVyKRIKARS molecular association, regulation cell motility, altered; cytoskeletal reorganization 19276087; 29396402 4 1 0 regulates T cell polarization and migration; signi?cantly impair the microtubule bundling activity of CRMP2, impaired binding to microtubules -TUBG1 TUBG1 Cytoskeletal; Motility/polarity/chemotaxis P23258 7283 17q21.2 human Y443-p 1876567500 HAATRPDyISWGTQE molecular association, regulation cytoskeletal reorganization GCP5(INDUCES) 35231444 1 1 0 -Rps6 S6 Translation P62754 20104 4|4 C4 mouse S247-p 448096 STSKSESsQK_____ carcinogenesis, induced; transcription, induced; transcription, altered 23361300; 34344824; 34819370 7 24 302 -Traf2 TRAF2 Autophagy; EC 6.3.2.-; Ligase; UBIQUITIN LIGASE; Ubiquitin conjugating system; Ubiquitin ligase P39429 22030 2|2 A3 mouse T117-p 471341 DGCTWKGtLKEYESC molecular association, regulation; ubiquitination; phosphorylation transcription, induced IKKA(INDUCES); IKKB(INDUCES) 19150425 2 0 0 induces IKB phosphorylation -Ezh2 EZH2 EC 2.1.1.43; METHYLTRANSFERASE; Methyltransferase; Methyltransferase, protein lysine Q61188 14056 6 B2.3|6 22.92 cM mouse T487-p 452848 VPTEDVDtPPRKKKR protein degradation 30305391 14 59 66 -DIXDC1 DIXDC1 Cell adhesion; Cell development/differentiation Q155Q3 85458 11q23.1 human S592-p 23099075 SKLPHSQsSPTVSST cytoskeletal reorganization 27829159 1 2 2 regulates microtubule network, dendritic spine growth -Rrad RRAD G protein; G protein, monomeric; G protein, monomeric, RGK NP_445790 83521 19p14 rat S300-p 4700229 AFRAKSKsCHDLSVL activity, induced 36215501 3 17 0 induces CaV1.2 activity -STXBP3 STXBP3 Vesicle O00186 6814 1p13.3 human Y521-p 459181 RQKPRANyLEDRKNG Sec1 molecular association, regulation; intracellular localization 24469400 5 8 68 molecular switch for SNARE complex formation ; localization to the plasma membrane -FLCN FLCN Tumor suppressor Q8NFG4 201163 17p11.2 human S537-p 23107124 EDTQKLLsILGASEE Folliculin_C molecular association, regulation FNIP2(INDUCES); LC3B(DISRUPTS); GABARAP(DISRUPTS) 25126726 1 1 1 -TREML1 TREML1 Immunoglobulin superfamily; Membrane protein, integral Q86YW5 340205 6p21.1 human Y281-p 454865 VCSKPVTyATVIFPG molecular association, regulation signaling pathway regulation SHIP-2(INDUCES) 15128762 2 2 18 enhanced calcium signaling -Xbp1 XBP1 DNA-binding; Transcription factor O35426 22433 11 A1|11 3.61 cM mouse T48-p 21688103 AGSEASGtPQARKRQ intracellular localization transcription, induced 21892182; 34030589 3 0 0 -CDKN1A p21Cip1 Cell cycle regulation; Inhibitor P38936 1026 6p21.2 human K154-ac 12615903 MTDFYHSkRRLIFSK protein stabilization; molecular association, regulation cell cycle regulation; carcinogenesis, inhibited; cell growth, inhibited C8A(DISRUPTS) 20154723 1 0 0 -PTEN PTEN Carbohydrate Metabolism - inositol phosphate; EC 3.1.3.16; EC 3.1.3.48; EC 3.1.3.67; Motility/polarity/chemotaxis; Nuclear receptor co-regulator; PHOSPHATASE; Phosphatase, lipid; Tumor suppressor P60484 5728 10q23.31 human Y315-p 448317 RADNDKEyLVLTLTK PTEN_C2 enzymatic activity, induced cell growth, altered 11948419 3 1 0 -Etv4 ETV4 DNA-binding P28322 18612 11 D|11 65.48 cM mouse K21-ac 26373303 VPYTFCSkSPGNGSL ETS_PEA3_N sumoylation transcription, induced 21543453 1 1 0 acetylated sites inhibits sumoylation reciprocally -SHOC2 SHOC2 Adaptor/scaffold; Protein phosphatase, regulatory subunit Q9UQ13 8036 10q25.2 human T507-p 1867945200 GLGENLLtHLPEEIG LRR_8 protein degradation; molecular association, regulation; ubiquitination; phosphorylation; enzymatic activity, induced cell growth, inhibited; apoptosis, induced; autophagy, inhibited; signaling pathway regulation FBXW7(INDUCES); Raptor(DISRUPTS); ERas(DISRUPTS) 30865892 1 0 0 disrupts binding to Raptor further inducing Raptor binding to mTORC1, induces S6K and 4E-BP1 phosphorylation through mTORC1 activation, inhibits Ras-MAPK signaling -Mcl1 MCL1 Apoptosis; Channel, misc.; Inhibitor; Membrane protein, integral; Mitochondrial P97287 17210 3 F2.1|3 40.74 cM mouse K175-ub 10837355 REQATGSkDSKPLGE protein degradation; molecular association, regulation; ubiquitination autophagy, induced beclin 1(DISRUPTS) 28053206; 32094511 4 5 33 -Cttn Cortactin Actin-binding; Cytoskeletal; Motility/polarity/chemotaxis NP_001385572 60465 1q41-q42 rat S172-p 15176497 QADRVDKsAVGFDYQ HS1_rep molecular association, regulation cytoskeletal reorganization ACTB(DISRUPTS) 26033110 1 4 0 phospho-mimetic mutant shows atypical growth cone filopodia -CCR7 CCR7 GPCR, family 1; Membrane protein, integral; Membrane protein, multi-pass; Motility/polarity/chemotaxis; Receptor, GPCR P32248 1236 17q21.2 human T372-p 455291 SMSVEAEtTTTFSP_ phosphorylation 15054093 1 0 0 ERK1/2 phosphorylation -PTK2 FAK EC 2.7.10.2; KINASE; Kinase, protein; Protein kinase, TK; Protein kinase, tyrosine (non-receptor) Q05397 5747 8q24.3 human Y194-p 18122800 ALEKKSNyEVLEKDV FERM_M protein conformation; phosphorylation; enzymatic activity, induced cell motility, altered; cell growth, altered 20802513 2 2 4 -Met Met EC 2.7.10.1; KINASE; Kinase, protein; Membrane protein, integral; Oncoprotein; Protein kinase, TK; Protein kinase, tyrosine (receptor) P16056 17295 6 A2|6 7.83 cM mouse Y1001-p 448469 VSNESVDyRATFPED ubiquitination cell motility, altered 12244174; 7708691 16 26 366 inhibits cell motility -Nrip1 RIP140 Nuclear receptor co-regulator; Transcription, coactivator/corepressor Q8CBD1 268903 16|16 C3.1 mouse Y418-p 25234800 TPTTIDEySDNNPSF NRIP1_repr_2 protein degradation; ubiquitination 22388040 1 0 0 regulates inflamatory responses and contributes to endotoxin tolerance -Ctnnd1 CTNND1 Actin-binding; Adaptor/scaffold; Cell adhesion; G protein regulator, misc.; Motility/polarity/chemotaxis P30999 12388 2 D|2 49.45 cM mouse S312-p 450458 ARRTGTPsDPRRRLR molecular association, regulation cell adhesion, inhibited 26175155 4 3 2 decreased homophilic binding affinity of E-cadherin -FOXM1 FOXM1 DNA-binding; Transcription factor Q08050 2305 12p13.33 human S730-p 3194570 VLDTMNDsLSKILLD cell cycle regulation; transcription, induced 19160488 2 6 0 orderly mitotic progression -TP53 p53 Activator; DNA-binding; Motility/polarity/chemotaxis; Nuclear receptor co-regulator; Transcription factor; Tumor suppressor P04637 7157 17p13.1 human R337-m2 5009201 LQIRGRErFEMFREL P53_tetramer cell cycle regulation; apoptosis, inhibited; transcription, altered 53BP1(INDUCES) 19011621 1 1 0 PRMT5 enhanced p53-dependent cell-cycle arrest; after treatment with PRMT5 theere was a reduction in dimer and tetramer formation; arginine methylation affects the promoter specificity of p53 -Ppm1h PPM1H EC 3.1.3.16; PHOSPHATASE; Phosphatase Q3UYC0 319468 10|10 D2 mouse S210-p 3215799 RTLTRAAsLRGGVGA phosphorylation; enzymatic activity, induced 32600616 1 22 23 dephosphorylation of SMAD1 -Smo SMO Cell development/differentiation; GPCR, Fz/Smo family; Membrane protein, integral; Membrane protein, multi-pass; Oncoprotein; Receptor, GPCR P56726 319757 6 A3.3|6 12.36 cM mouse T648-p 1872776124 VSVTPVAtPVPPEEQ molecular association, regulation transcription, induced PKACA(INDUCES) 33886552 1 1 0 -ABI1 Abi-1 Adaptor/scaffold; Motility/polarity/chemotaxis Q8IZP0 10006 10p12.1 human T265-p 18715504 GIPIAVPtPSPPTIG molecular association, regulation cell motility, altered; cytoskeletal reorganization 21419341 1 0 2 regulates WRC (WAVE2 regulatory complex) interaction with Arp2/3 and lamellipodial protrusion -INCENP INCENP Cell cycle regulation; EC 2.7.11.1 Q9NQS7 3619 11q12.3 human T59-p 458332 EPELMPKtPSQKNRR molecular association, regulation; intracellular localization cell cycle regulation; chromatin organization, altered KIF20A(DISRUPTS) DNA(DISRUPTS) 19303298; 20619651; 22814604; 29084198; 32356865; 33067654 9 6 21 -Clip1 Restin Cytoskeletal Q922J3 56430 5|5 F mouse S311-p 4769833 ASLKRSPsASSLSSM intracellular localization cytoskeletal reorganization 33251722 4 13 1 -F2R PAR1 Cell development/differentiation; GPCR, family 1; Membrane protein, integral; Membrane protein, multi-pass; Receptor, GPCR P25116 2149 5q13.3 human S406-p 3627500 SSGQLMAsKMDTCSS receptor desensitization, altered 10413505 1 0 0 receptor shutoff (not internalization) -Spi1 PU.1 DNA-binding; Oncoprotein; Transcription factor P17433 20375 2 E1|2 50.44 cM mouse S132-p 478389 LSPAHQQsSDEEEGE molecular association, regulation IRF8(INDUCES); PU.1(INDUCES); IRF2(INDUCES) 17200120 1 1 0 Interaction of PU.1, IRF-2, and IRF-8 requires phosphorylated residues on each protein. -Pcna PCNA Cell cycle regulation; DNA replication P17918 18538 2 F2|2 64.15 cM mouse K164-ub 485775 AVVISCAkNGVKFSA PCNA_C DNA repair, induced; DNA repair, altered 25505145; 28761001 33 14 135 DNA damage tolerance (DDT) allows bypassing of DNA lesions during replication. Translesion synthesis (TLS), template switching (TS) are dependant on PCNA K164 monoubiquitination and polyubiquitination.; K164 ubquitination is importaqnt for bypass of methyl methanesulfonate-induced DNA damage -RIPK1 RIPK1 EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, Ser/Thr (non-receptor); Protein kinase, TKL Q13546 8737 6p25.2 human S320-p 468644 AVVKRMQsLQLDCVA molecular association, regulation; enzymatic activity, inhibited apoptosis, inhibited FADD(DISRUPTS) 28506461; 34965934 11 27 34 -MYLIP MYLIP EC 6.3.2.-; EC 6.3.2.19; Ligase; Motility/polarity/chemotaxis; UBIQUITIN LIGASE; Ubiquitin conjugating system; Ubiquitin ligase Q8WY64 29116 6p22.3 human K293-sm 1881268800 MQYSRDLkGHLASLF protein stabilization endocytosis, inhibited 33154164 1 0 0 counteracts its ubiquitination -ITGB5 ITGB5 Cell adhesion; Membrane protein, integral; Motility/polarity/chemotaxis P18084 3693 3q21.2 human S762-p 14694703 AKFQSERsRARYEMA Integrin_b_cyt cell motility, altered 20507994 1 0 0 -PPARG PPAR-gamma DNA-binding; Nuclear receptor; Transcription factor P37231 5468 3p25.2 human T166-p 1880248400 CKGFFRRtIRLKLIY molecular association, regulation; protein conformation cell differentiation, altered; transcription, inhibited PRDM16(DISRUPTS); PGC-1 alpha(DISRUPTS) DNA(DISRUPTS) 36329235 1 0 0 -CEBPA C/EBP-alpha DNA-binding; Transcription factor P49715 1050 19q13.11 human K298-ac 56394104 RNNIAVRkSRDKAKQ bZIP_2 molecular association, regulation cell differentiation, inhibited; transcription, inhibited DNA(DISRUPTS) 27005833 2 0 0 -Tmbim1 TMBIM1 Membrane protein, integral; Membrane protein, multi-pass Q8BJZ3 69660 1|1 C3 mouse K91-ub 1873041102 PGEWDDRkVRHSFIQ molecular association, regulation Hrs(INDUCES) 28481357 1 1 0 -KDM8 JMJD5 Cell cycle regulation; DEMETHYLASE; Demethylase; EC 1.14.11.27 Q8N371 79831 16p12.1 human S361-p 1877127906 THLLHNTsQVDVENP Cupin_8 protein degradation carcinogenesis, inhibited; cell growth, inhibited 35538499 1 1 0 -SP1 SP1 C2H2-type zinc finger protein; DNA-binding; Transcription factor P08047 6667 12q13.13 human T679-p 25312143 ELQRHKRtHTGEKKF zf-C2H2 protein stabilization; molecular association, regulation carcinogenesis, induced; cell motility, induced; transcription, induced; signaling pathway regulation DNA(INDUCES) 22718198 1 0 1 AKT/SP1/CCR7 pathway -ADRA2A ADRA2A GPCR, family 1; Membrane protein, integral; Membrane protein, multi-pass; Receptor, GPCR P08913 150 10q25.2 human S313-p 456351 LDLEESSsSDHAERP 7tm_1 activity, inhibited 7876239 1 2 0 -TAL1 TAL1 DNA-binding; Oncoprotein; Transcription factor P17542 6886 1p33 human S172-p 4704529 NRVKRRPsPYEMEIT molecular association, regulation transcription, induced LSD1(DISRUPTS) 22310283 2 2 1 -Dcx Doublecortin Cytoskeletal; Motility/polarity/chemotaxis O88809 13193 X|X F2 mouse S47-p 451112 TRTLQALsNEKKAKK molecular association, regulation cell motility, induced; cytoskeletal reorganization TUBA1A(NOT_REPORTED); SPATA13 iso6(INDUCES) 22367209 5 0 0 Rac1 activation, lamellipodia formation -Eif3f eIF3-epsilon EC 3.4.19.12; Translation; Translation initiation Q9DCH4 66085 7|7 E3 mouse K218-ub 7388005 QHGRMSIkAYVSTLM protein degradation 19073596 1 1 0 regulates skeletal muscle atrophy -TRPM8 TRPM8 Channel, cation; Membrane protein, integral; Membrane protein, multi-pass Q7Z2W7 79054 2q37.1 human S1041-p 34360658 KEKNMESsVCCFKNE receptor desensitization, inhibited 32290846 1 0 1 -CTTN Cortactin Actin-binding; Cytoskeletal; Motility/polarity/chemotaxis Q14247 2017 11q13.3 human K203-ac 482876 GGKYGIDkDKVDKSA HS1_rep molecular association, regulation; intracellular localization cell motility, inhibited ACTB(DISRUPTS) 17643370 1 1 0 Acetylation prevents localization to membrane ruf?es. -USP2 USP2 DEUBIQUITINASE; EC 3.4.19.12; Protease; Ubiquitin-specific protease O75604 9099 11q23.3 human T137-p 1880716200 YDQGVTLtQKLDSQS molecular association, regulation DNA repair, induced RECQL4(INDUCES) DNA(INDUCES) 36436562 1 0 0 -Grip1 GRIP1 Adaptor/scaffold P97879 84016 7q22 rat S917-p 471402 EATIMSGsTMSLNHE phosphorylation 17121843 2 0 1 Wild-type GRIP1 and mutant S19A there was a reduction in GluR2 surface expression, while S917 had no effect. -UBE2S UBE2S EC 6.3.2.19; Ligase; UBIQUITIN LIGASE; Ubiquitin conjugating system; Ubiquitin ligase Q16763 27338 19q13.42 human T152-p 58109405 AARARLLtEIHGGAG UQ_con protein stabilization; molecular association, regulation DNA repair, induced Ku80(INDUCES); Ku70(INDUCES) 27593939 1 0 0 -Il1b IL1B Cytokine P10749 16176 2 F1|2 62.97 cM mouse K133-ub 1881312000 RLRDEQQkSLVLSDP protein degradation 33976225 1 0 0 forms an electrostatic interaction with D129, loss of K133 ubiquitylation or the K133:D129 salt bridge stabilizes IL-1B -CTNNB1 CTNNB1 Actin-binding; Cell adhesion; Motility/polarity/chemotaxis; Nuclear receptor co-regulator; Oncoprotein; Transcription factor P35222 1499 3p22.1 human S60-p 1875093002 EEEDVDTsQVLYEWE molecular association, regulation cell cycle regulation ECT2(INDUCES) 34585824 2 0 0 -AHSG FETUA Secreted; Secreted, signal peptide P02765 197 3q27.3 human S138-p 467421 KCDSSPDsAEDVRKV carcinogenesis, induced 36114575 1 55 604 -CILK1 ICK EC 2.7.11.22; KINASE; Kinase, protein; Protein kinase, CMGC; Protein kinase, Ser/Thr (non-receptor) Q9UPZ9 22858 6p12.1 human Y15-p 35479600 RQLGDGTyGSVLLGR Pkinase intracellular localization; enzymatic activity, inhibited signaling pathway regulation 30782830 1 1 0 -TNK2 Ack EC 2.7.10.2; EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, TK; Protein kinase, tyrosine (non-receptor) Q07912 10188 3q29 human Y635-p 4251154 PLPPPPAyDDVAQDE molecular association, regulation; enzymatic activity, induced carcinogenesis, induced; cell growth, induced; transcription, induced; signaling pathway regulation Akt1(INDUCES) 25257795 1 2 5 PDGF-induced PDGFRB-ACK1-AKT signaling -ACP1 ACP1 Cofactor and Vitamin Metabolism - riboflavin; EC 3.1.3.2; EC 3.1.3.48; Motility/polarity/chemotaxis; PHOSPHATASE; Phosphatase (non-protein); Protein phosphatase, tyrosine (non-receptor) P24666 52 2p25.3 human Y132-p 450718 QLIIEDPyYGNDSDF LMWPc phosphorylation; enzymatic activity, induced cell motility, altered; cell adhesion, altered; transcription, altered 10671492; 10980198; 9038134 5 15 194 regulates phosphorylation of p190Rho-GAP; dephosphorylation of RhoGAP, regulates ERK activation -Epha2 EphA2 EC 2.7.10.1; KINASE; Kinase, protein; Membrane protein, integral; Protein kinase, TK; Protein kinase, tyrosine (receptor) Q03145 13836 4 D3|4 73.67 cM mouse Y773-p 450861 EDDPEATyTTSGGKI PK_Tyr_Ser-Thr intracellular localization; phosphorylation cell adhesion, induced; cytoskeletal reorganization 34537369 6 55 860 induces MLC phosphorylation -DUSP10 DUSP10 EC 3.1.3.16; EC 3.1.3.48; Motility/polarity/chemotaxis; PHOSPHATASE; Protein phosphatase, dual-specificity Q9Y6W6 11221 1q41 human S230-p 38520205 DSFKRIFsKEIIVYD Rhodanese cell growth, inhibited; apoptosis, induced 25568665 1 0 0 -CDCA5 CDCA5 Cell cycle regulation Q96FF9 113130 11q13.1 human T159-p 483401 LGSASTStPGRRSCF Sororin molecular association, regulation; activity, inhibited cell cycle regulation SCC-112(DISRUPTS); H2A.1(DISRUPTS); SMC3(DISRUPTS); PLK1(INDUCES) 21878504; 21987589; 23901111 3 10 14 -ZNF692 ZNF692 C2H2-type zinc finger protein; Transcription factor Q9BU19 55657 1q44 human S470-p 471395 VAAHRSKsHPALLLA transcription, inhibited 17097062 1 0 0 inhibits DNA binding and transcription -Hdac1 HDAC1 DEACETYLASE; Deacetylase; EC 3.5.1.98; Hydrolase; Nuclear receptor co-regulator Q4QQW4 297893 5q36 rat K444-sm 2407421 FKKAKRVkTEDEKEK molecular association, regulation neural plasticity; apoptosis, inhibited CREB iso1(DISRUPTS) 28186506 3 1 0 sumoylation rescues synaptic and memory deficits, and reduces amyloid plaque and apoptosis in APP/PS1 mice; Sumoylation increases CREB binding to DNA and mediates A? induction of Mcl-1 expression -KRAS KRas iso2 G protein; G protein, monomeric; G protein, monomeric, Ras; Motility/polarity/chemotaxis; Oncoprotein P01116-2 3845 12p12.1 human K147-ub 15391092 PFIETSAkTRQGVDD Ras protein conformation 33929846 4 6 3 K147 affected the dynamics of SW-I and SW-II residues and parts of H3, CRD-interacting residues of KRAS do not make direct contact with ubiquitin, KRAS?GAP interface in nearly all of the simulated conformers of mUbKRAS147 -ESR1 ER-alpha DNA-binding; Nuclear receptor; Transcription factor P03372 2099 6q25.1-q25.2 human Y537-p 448103 CKNVVPLyDLLLEML activity, induced; protein stabilization; molecular association, regulation; intracellular localization; protein conformation cell growth, induced; transcription, induced PGC-1 alpha(DISRUPTS); EGFR(INDUCES); SRC-1(DISRUPTS) DNA(INDUCES) 10571988; 25386784; 26079946; 27748765; 9500442 10 0 0 -RAD54L RAD54L Cell cycle regulation; DNA repair, damage; EC 3.6.1.-; EC 3.6.4.-; Helicase Q92698 8438 1p34.1 human K515-ac 1876747700 TRSRSSDkVVLVSNY Helicase_C molecular association, regulation DNA repair, induced BRD9(INDUCES) 32457312 1 0 0 Facilitates RAD54 interaction with RAD51, essential for homologous recombination but also cancer drug resistance -Myc Myc DNA-binding; Nucleolus; Oncoprotein; Transcription factor P01108 17869 15 D1|15 26.19 cM mouse K432-ac 460639 EHKLTSEkDLLRKRR Myc-LZ protein stabilization transcription, induced 15572685 1 1 0 -UBA52-RPS27A-UBB-UBC ubiquitin Ubiquitin-like modifier P62988 2p16 human K29-ub 3135200 TIENVKAkIQDKEGI ubiquitin activity, induced; protein degradation; ubiquitination; protein conformation cell cycle regulation; DNA repair, induced; endocytosis, induced; cell growth, inhibited; transcription, induced; transcription, inhibited 31012223; 31135381; 31902824; 32054686; 34239127; 36563124 18 20 136 RNA processing, proteotoxic stress induced K29-linked ubiquitination, reducing K29-linked ubiquitination led to cell cycle arrest, TBK1, PLK1, INCENP and MLKP1 as potential substrates of K29-linked ubiquitination during midbody assembly; USP16 regulates T cell proliferation and cell-cycle entry; promotes loop 1?loop 7 interaction, cholesterol biosynthesis; Ubiquitination of PPP3CB impairs NFAT recruitment and transcription of NFAT-targeted genes; MRE11A promotes its exonuclease activity; clathrin-mediated endocytosis, poly-Ub chain binds to Lys8 at the intracellular N-terminal domain, degradation depends on the poly-ubiquitination of K8; CACNA1C degradation -AIFM1 PDCD8 Apoptosis; EC 1.-.-.-; Mitochondrial; Oxidoreductase O95831 9131 Xq26.1 human K255-ub 573760204 GSQITYEkCLIATGG Pyr_redox_2 molecular association, regulation DNA(INDUCES) 33898171 1 3 0 Deubiquitination of AIF at K244 compromises OXPHOS and induces a switch in cellular metabolism towards glycolysis and disrupts mitochondrial structure. -Camk2b CAMK2B EC 2.7.11.17; KINASE; Kinase, protein; Protein kinase, CAMK; Protein kinase, Ser/Thr (non-receptor) P08413 24245 14q21 rat T321-p 2048069 FSVGRQTtAPATMST molecular association, regulation 26291163 1 2 0 inhibits interaction with F-actin, regulates synaptic plasticity -UBA52-RPS27A-UBB-UBC ubiquitin Ubiquitin-like modifier P62988 2p16 human S65-p 9765472 DYNIQKEsTLHLVLR ubiquitin activity, induced; protein degradation; molecular association, regulation; ubiquitination; intracellular localization; protein conformation; enzymatic activity, induced autophagy, induced optineurin(DISRUPTS); ubiquitin(INDUCES); PARK2(INDUCES) 24660806; 24751536; 24784582; 25527291; 25847540; 25969509; 26161729; 26254304; 26260794; 27035970; 27425610; 28611216; 29133469; 31801089; 34706234 27 17 0 induces mitophagy; improved binding to PINK1 through its extended S65 loop, and is a superior PINK1 substrate; pH change leads to quaternary rearrangement of a phosphorylated K63-linked diubiquitin; modest effects on UBE3C ligase activity ; p-S65 ubiquitin and downstream Parkin-dependent mitophagy, counteracted by PPEF2 -PTK2 FAK iso5 EC 2.7.10.2; KINASE; Kinase, protein; Protein kinase, TK; Protein kinase, tyrosine (non-receptor) Q92063 396416 chicken S30-p 447962 PSRPGYPsPRSSEGF molecular association, regulation P130Cas(DISRUPTS) 11160818 9 18 0 -EMSY EMSY DNA repair, damage; Transcription regulation Q7Z589 56946 11q13.5 human T207-p 1210942 KPRKRRRtNSSSSSP DNA repair, inhibited 28099152 1 18 22 -Tcf3 E2A iso2 Cell development/differentiation; DNA-binding; Oncoprotein; Transcription factor P15806-2 21423 10 C1|10 39.72 cM mouse S527-p 483180 VPRTRTSsTDEVLSL molecular association, regulation 14-3-3 beta(INDUCES) 22354994 1 23 307 -TP73 p73 DNA-binding; Transcription factor; Tumor suppressor O15350 7161 1p36.32 human S388-p 6417400 VPQPLVDsYRQQQQL activity, induced cell cycle regulation; transcription, altered 19158275 1 0 0 regulates genes involved in cell cycle progression -Trpv6 TRPV6 Channel, calcium; Membrane protein, integral; Membrane protein, multi-pass Q9R186 114246 4q23 rat Y202-p 473578 RPHNLIYyGEHPLSF activity, induced 17197020 1 0 0 regulates calcium influx -Prkaa1 AMPKA1 Autophagy; EC 2.7.11.1; EC 2.7.11.26; EC 2.7.11.27; EC 2.7.11.31; KINASE; Kinase, protein; Protein kinase, CAMK; Protein kinase, Ser/Thr (non-receptor) Q5EG47 105787 15|15 A1 mouse S184-p 3195152 DGEFLRTsCGSPNYA Pkinase phosphorylation autophagy, induced 19942859; 35256937 2 6 16 -BHLHE40 BHLHB2 Nucleolus; Transcription regulation O14503 8553 3p26.1 human K279-sm 31089508 GERIGAIkQESEEPP protein stabilization; intracellular localization transcription, inhibited 21829689; 27626674 2 3 0 -HSF1 HSF1 DNA-binding; Transcription factor Q00613 3297 8q24.3 human T120-p 54414377 ENIKRKVtSVSTLKS protein stabilization; molecular association, regulation; protein conformation carcinogenesis, induced; autophagy, induced; cell motility, induced; cell growth, induced; transcription, induced FBXW7(DISRUPTS) DNA(INDUCES) 31409638 1 1 0 promotes carboplatin-induced autophagy; induces proteostasis; binds to PDL-1, HSP70 and HSP40 promoters -FOXO3 FOXO3A Autophagy; DNA-binding; Oncoprotein; Transcription factor O43524 2309 6q21 human S588-p 20799904 QTLSDSLsGSSLYST phosphorylation transcription, induced 17711846 2 1 0 induces phosphorylation of other sites -CCNA2 CCNA2 Cell cycle regulation; Nuclear receptor co-regulator P20248 890 4q27 human K112-ac 7761215 EAEKEAQkKPAESQK Cyclin_N2 protein degradation; molecular association, regulation cell cycle regulation CDK2(DISRUPTS) 19483727; 23760262 2 1 0 -PHOX2A PHOX2A DNA-binding; Transcription factor O14813 401 11q13.4 human S208-p 9400301 ASPRLSPsPLPVALG phosphorylation 19564421 1 2 0 regulates phosphorylation of PHOX2A S153 -NFATC1 NFAT2 DNA-binding; Transcription factor O95644 4772 18q23 human T338-p 1869090804 VPVKSRKtTLEQPPS activity, induced carcinogenesis, induced; cell motility, induced; transcription, induced 31730483 1 0 0 multiple sites mutatnt -KCNQ2 Kv7.2 iso3 Channel, potassium; Membrane protein, integral; Membrane protein, multi-pass O43526-3 3785 20q13.33 human S511-p 12200523 LTPGLKVsIRAVCVM KCNQ_channel activity, induced; molecular association, regulation; intracellular localization Calmodulin(DISRUPTS) 21980481 1 0 0 increases maximal conductance; not an integral part of the M-channel -ARHGAP22 ARHGAP22 GAP; GAP, Rac/Rho Q7Z5H3 58504 10q11.22-q11.23 human S395-p 4751993 LPAHRTSsLDGAAVA molecular association, regulation cell motility, induced 14-3-3 beta(INDUCES) 21969604 2 16 0 -Ptpa PPP2R4 EC 5.2.1.8; Motility/polarity/chemotaxis; Protein phosphatase, regulatory subunit P58389 110854 2 B|2 21.71 cM mouse K310-ub 41493162 FPVIQHFkFGSLLPI PTPA protein degradation; ubiquitination; methylation cytoskeletal reorganization 31160454 1 4 0 mediating the effects of UBE3A on spine morphology. -PML PML iso4 Nucleolus; Oncoprotein; SUMO LIGASE; SUMO conjugating system; SUMO ligase; Transcription factor; Tumor suppressor; Ubiquitin conjugating system P29590-4 5371 15q24.1 human S36-p 451469 PSEGRQPsPSPSPTE protein stabilization apoptosis, altered 15093545 2 15 0 Phosphorylation of PML is associated with enhanced sumoylation and apoptosis induced by As2O3. -TP53 p53 Activator; DNA-binding; Motility/polarity/chemotaxis; Nuclear receptor co-regulator; Transcription factor; Tumor suppressor P04637 7157 17p13.1 human K320-ub 10888802 SSSPQPKkKPLDGEY P53_tetramer protein degradation; molecular association, regulation; intracellular localization KPNA4(DISRUPTS) 19927155 1 2 16 -ARAF ARAF EC 2.7.11.1; KINASE; Kinase, protein; Oncoprotein; Protein kinase, Ser/Thr (non-receptor); Protein kinase, TKL P10398 369 Xp11.3 human S257-p 467474 SDGTPRGsPSPASVS enzymatic activity, induced 18662992 2 30 61 -Emd emerin Cytoskeletal; Membrane protein, integral O08579 13726 X A7.3|X 37.92 cM mouse Y96-p 448938 KDYNDDYyEESYLTT cell motility, induced; transcription, induced; cytoskeletal reorganization 24609268 3 5 124 Y75F and Y96F had reduced expression of vinculin and SRF.; mechanical adaptation of isolated nuclei to force -HNRNPK hnRNP K RNA splicing; RNA-binding; Spliceosome P61978 3190 9q21.32 human Y225-p 456000 IKGRAQPyDPNFYDE translation, altered 12052863 1 1 1 based on Y72/225/230/234/236/380A mutant -IL9R IL9R Membrane protein, integral; Receptor, cytokine Q01113 3581 Xq28 and Yq12 human T520-p 450657 LSKARSWtF______ molecular association, regulation 14-3-3 zeta(INDUCES) 10642536 1 0 0 -ATR ATR EC 2.7.11.1; KINASE; Kinase, protein; Membrane protein, integral; Protein kinase, Ser/Thr (non-receptor); Protein kinase, atypical Q13535 545 3q23 human S428-p 456320 SSNSDGIsPKRRRLS activity, induced; molecular association, regulation; ubiquitination; intracellular localization; phosphorylation; enzymatic activity, induced cell cycle regulation; DNA repair, induced; apoptosis, induced; cell growth, induced; DNA repair, inhibited; transcription, altered; cell growth, altered PIN1(INDUCES); BID(INDUCES) 17976513; 24639502; 26387736; 33857133; 34718349; 35951367; 36563124 25 13 1 MRE11A promotes its exonuclease activity -HOXA10 HOXA10 DNA-binding; Transcription factor P31260 3206 7p15.2 human Y360-p 455551 KEFLFNMyLTRERRL Homeodomain molecular association, regulation; activity, inhibited transcription, induced HOXA10(INDUCES) 12145285 1 0 0 phosphorylation decreases Hox-A10 DNA binding affinity and transcriptional repression activity. -PML PML Nucleolus; Oncoprotein; SUMO LIGASE; SUMO conjugating system; SUMO ligase; Transcription factor; Tumor suppressor; Ubiquitin conjugating system P29590 5371 15q24.1 human S565-p 2479600 VISSSEDsDAENSSS DUF3583 protein degradation; molecular association, regulation apoptosis, inhibited; cell growth, altered SUMO2(INDUCES); SUMO1(INDUCES); SUMO3(INDUCES) 16873060; 19380586 3 11 0 -Kif2a KIF2A iso1 Microtubule-binding; Motor P28740-1 16563 13|13 D2.1 mouse T482-p 50269511 PFRASKLtQVLRDSF Kinesin cytoskeletal reorganization 26344760 1 1 0 suppress neurite outgrowth from round cells -SPTLC1 SPTLC1 EC 2.3.1.50; Lipid Metabolism - sphingolipid; Membrane protein, integral; Transferase O15269 10558 9q22.31 human Y164-p 27930808 KTEEAIIySYGFATI Aminotran_1_2 intracellular localization; enzymatic activity, inhibited apoptosis, inhibited 23629659 1 0 0 -Crhr1 CRF-R1 GPCR, family 2; Membrane protein, integral; Membrane protein, multi-pass; Receptor, GPCR P35353 58959 10q32.1 rat S408-p 2859802 PTRVSFHsIKQSTAV receptor desensitization, altered; receptor internalization, altered 17913459 1 2 2 -PDE11A PDE11A EC 3.1.4.17; EC 3.1.4.35; Mitochondrial; Nucleotide Metabolism - purine; Phosphodiesterase Q9HCR9 50940 2q31.2 human S162-p 2243100 RALLRKAsSLPPTTA enzymatic activity, induced 18312413 2 3 0 -Nr1i3 NR1I3 DNA-binding; Nuclear receptor O35627 12355 1 H3|1 79.21 cM mouse S202-p 458347 LTMEDQIsLLKGAAV Hormone_recep intracellular localization 16377764 1 0 1 -SMAD1 SMAD1 DNA-binding; Transcription factor Q15797 4086 4q31.21 human S463-p 448362 SPHNPISsVS_____ activity, induced; molecular association, regulation; intracellular localization cell growth, inhibited; transcription, induced; transcription, altered SMAD4(INDUCES) 35573984; 9136927; 9335504 12 13 58 -PDHA2 PDHA2 Amino Acid Metabolism - valine, leucine and isoleucine biosynthesis; Carbohydrate Metabolism - butanoate; Carbohydrate Metabolism - citrate (TCA) cycle; Carbohydrate Metabolism - glycolysis and gluconeogenesis; Carbohydrate Metabolism - pyruvate; EC 1.2.4.1; Mitochondrial; Oxidoreductase P29803 5161 4q22.3 human S291-p 458869 TYRYHGHsMSDPGVS E1_dh enzymatic activity, induced 16436377 1 64 617 -MAPRE3 EB3 Microtubule-binding Q9UPY8 22924 2p23.3 human S176-p 4740060 MQTSGRLsNVAPPCI protein stabilization; molecular association, regulation; ubiquitination cell cycle regulation; cytoskeletal reorganization SIAH1(DISRUPTS) 19696028; 23712260 2 6 0 controls microtubule dynamics-cell spreading and adhesion, induces midbody microtubule stability -Sox9 SOX9 DNA-binding; Transcription factor Q04887 20682 11 E2|11 77.27 cM mouse S181-p 456981 YQPRRRKsVKNGQAE activity, induced; intracellular localization carcinogenesis, induced; cell differentiation, induced; transcription, induced 30412364; 33985544; 34254999 12 2 0 -Rps6kb1 p70S6K EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, AGC; Protein kinase, Ser/Thr (non-receptor); Translation Q8BSK8 72508 11|11 C mouse K507-ac 32640201 QPNSGPYkKQAFPMI cell growth, induced 27345368 3 0 0 -P2RY4 P2RY4 GPCR, family 1; Membrane protein, integral; Membrane protein, multi-pass; Receptor, GPCR P51582 5030 Xq13.1 human S334-p 10349701 QPRTAASsLALVSLP receptor desensitization, altered; receptor internalization, altered 11114308 1 0 0 -SNCA SNCA Adaptor/scaffold P37840 6622 4q22.1 human S87-gl 6311902 KTVEGAGsIAAATGF Synuclein protein stabilization 30651314 0 2 0 inhibits the aggregation of alpha-synuclein but can also alter the structure of a-synuclein aggregates in site specific ways, inhibit a-Synuclein toxicity -SPRY2 SPRY2 Adaptor/scaffold; Inhibitor; Motility/polarity/chemotaxis O43597 10253 13q31.1 human Y55-p 448849 AIRNTNEyTEGPTVV activity, induced; protein degradation; molecular association, regulation; activity, inhibited; phosphorylation cell differentiation, altered; transcription, altered GRB2(INDUCES); CBL(INDUCES) 12593795; 12815057; 15564375; 15637081; 16000370; 16479008; 17255109 10 6 89 -CD36 CD36 Cell adhesion; Membrane protein, integral; Membrane protein, multi-pass P16671 948 7q21.11 human K469-ub 2363100 SYCACRSkTIK____ protein degradation; molecular association, regulation; ubiquitination IRS1(INDUCES) 18316598; 29269414 2 0 0 inhibits insulin-stimulated IRS1 degradation, disrupts IRS1 interaction with CUL7 and Fyn, regulates IRS1 ubiquitination -Ankrd54 ANKRD54 Cell cycle regulation Q91WK7 223690 15 E1|15 37.7 cM mouse S17-p 239773905 DESRSGRsSSDGECA molecular association, regulation; intracellular localization LYN(INDUCES) 28924458 1 1 0 nuclear export, cytoplasmic accumulation -CSNK1E CK1E EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, CK1; Protein kinase, Ser/Thr (non-receptor) P49674 1454 22q13.1 human S368-p 449793 NTSPRAIsRVDRERK enzymatic activity, inhibited 10542239; 12223474 2 0 0 some subset of these 8 sites -Oprk1 KOR-1 GPCR, family 1; Membrane protein, integral; Membrane protein, multi-pass; Receptor, GPCR P34975 29335 5q12 rat S369-p 449609 NTVQDPAsMRDVGGM activity, induced; receptor desensitization, altered; receptor internalization, altered; phosphorylation signaling pathway regulation 12815037; 21370032; 31575661 11 1 0 ROS generation through activating JNK-PRDX6 pathway; induces phosphorylation of ERK1/2 and p38MAPK, induces KOR/ p38MAPK signaling -Traf6 TRAF6 EC 6.3.2.-; Ligase; UBIQUITIN LIGASE; Ubiquitin conjugating system; Ubiquitin ligase P70196 22034 2|2 E2 mouse S48-p 1040254702 STGNLSSsFMEEIQG ubiquitination 29563609 1 0 0 colon epithelia in?ammation -ETV1 ETV1 DNA-binding; Oncoprotein; Transcription factor P50549 2115 7p21.2 human T143-p 3059604 NPPTPSStPVSPLHH ETS_PEA3_N activity, induced transcription, induced 12213813 2 0 0 -ELK1 ELK1 DNA-binding; Transcription factor P19419 2002 Xp11.23 human S324-p 471887 RDLELPLsPSLLGGP activity, induced; protein conformation transcription, induced 8262053 2 12 9 -Irf3 IRF3 DNA-binding; Transcription factor P70671 54131 7|7 B3 mouse S97-p 51637401 LRLAADNsKDPYDPH IRF intracellular localization 26692175 4 2 0 dephosphorylated S97 promoted nuclear import -CDKN2D CDKN2D Cell cycle regulation; Inhibitor; Tumor suppressor P55273 1032 19p13.2 human T141-p 25256101 RRDARGLtPLELALQ Ank_2 phosphorylation cell cycle regulation; cell growth, induced 22558186 1 1 0 S76/T141 phosphorylation is necessary for CDKN2D function in DNA repair.; S76 is phosphorylated first, followed by T141 phosphorylation. -PIAS1 PIAS1 EC 6.3.2.-; Nuclear receptor co-regulator; SUMO LIGASE; SUMO conjugating system; SUMO ligase; Transcription, coactivator/corepressor O75925 8554 15q23 human S522-p 3177709 DTSYINTsLIQDYRH sumoylation; enzymatic activity, induced transcription, inhibited 23202365 1 1 0 ; PIAS1 S522A expression inhibits TNF-induced sumoylation of p53; inhibits inflammatory genes expression -RBM39 RNPC2 Nuclear receptor co-regulator; RNA-binding; Spliceosome Q14498 9584 20q11.22 human Y99-p 12244420 RGRYRSPySGPKFNS transcription, induced 27018250 1 4 55 expression of ER (or PR) responsive genes -EZH2 EZH2 EC 2.1.1.43; METHYLTRANSFERASE; Methyltransferase; Methyltransferase, protein lysine Q15910 2146 7q36.1 human T311-p 34490427 NTYKRKNtETALDNK molecular association, regulation; enzymatic activity, inhibited carcinogenesis, inhibited; cell growth, inhibited; transcription, induced SUZ12(INDUCES); RBBP4(DISRUPTS); SUZ12(DISRUPTS) 29351847; 34775498 4 2 0 -SUPT5H SPT5 RNA-binding; Transcription, coactivator/corepressor O00267 6829 19q13.2 human S666-p 468817 VGGFAPMsPRISSPM transcription, induced 34534457 5 85 10 -Prkcd PKCD EC 2.7.11.13; KINASE; Kinase, protein; Nuclear receptor co-regulator; Protein kinase, AGC; Protein kinase, Ser/Thr (non-receptor); Protein kinase, tyrosine (non-receptor); Tumor suppressor P09215 170538 16p16 rat Y512-p 450078 TFCGTPDyIAPEILQ Pkinase enzymatic activity, induced 9326592 3 3 2 -ESRRG ERR3 DNA-binding; Nuclear receptor; Transcription factor P62508 2104 1q41 human K40-sm 6048402 SSCSSFIkTEPSSPA transcription, inhibited 19067653 2 0 0 -Adrb2 ADRB2 GPCR, family 1; Membrane protein, integral; Membrane protein, multi-pass; Receptor, GPCR P04274 101836719 hamster S262-p 447909 GHGLRRSsKFCLKEH 7tm_1 receptor desensitization, altered 8083204 15 2 1 S262 was primary site of cAPK desensitization, while either 261 or 262 for PKC desensitization, as well as ADRB2 expression level. -VHL VHL Tumor suppressor; UBIQUITIN LIGASE; Ubiquitin ligase P40337 7428 3p25.3 human S168-p 27434501 RCLQVVRsLVKPENY VHL_C protein degradation cytoskeletal reorganization 23255108 1 0 0 proteasomal degradation and ciliary destabilization -Nacc1 NAC1 Transcription factor O35260 171454 19q11 rat S245-p 457535 CVSGPSMsERTSPGT intracellular localization 16045493 1 0 0 -MCL1 MCL1 Apoptosis; Channel, misc.; Inhibitor; Membrane protein, integral; Mitochondrial Q07820 4170 1q21.2 human T301-p 1868532700 ITDVLVRtKRDWLVK Bcl-2 molecular association, regulation cell cycle regulation; apoptosis, induced MCL1(INDUCES) 32322059 1 0 0 -Cacng2 Stargazin Channel, calcium; Membrane protein, integral; Membrane protein, multi-pass O88602 12300 15 E1|15 36.92 cM mouse S237-p 455314 RYRYQRRsRSSSRST activity, induced; intracellular localization 15664178; 20670832 3 0 0 AMPAR immobilization in synaptic membrane; enhances AMPA receptor responses and is required for long-term potentiation -BRAF BRAF EC 2.7.11.1; KINASE; Kinase, protein; Oncoprotein; Protein kinase, Ser/Thr (non-receptor); Protein kinase, TKL P15056 673 7q34 human S467-p 28070701 GQRIGSGsFGTVYKG PK_Tyr_Ser-Thr molecular association, regulation; activity, inhibited BRAF(DISRUPTS) 31929109 2 1 0 -ROCK1 ROCK1 EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, AGC; Protein kinase, Ser/Thr (non-receptor) Q13464 6093 18q11.1 human S456-p 2526073 MEQKCRTsNIKLDKI signaling pathway regulation 34530870 1 2 0 induces RhoA/ROCK1/MYPT1 signaling -KIF4A KIF4A Microtubule-binding; Motor O95239 24137 Xq13.1 human K460-sm 610814348 TLEDQELkENVEIIC molecular association, regulation cell cycle regulation STMN1(INDUCES) 32591481 1 2 0 KIF4A regulates abscission, enhances binding to STMN1 identified by mass spectrometry -GLI1 GLI1 C2H2-type zinc finger protein; Oncoprotein; Transcription factor P08151 2735 12q13.3 human S84-p 25123902 LTKKRALsISPLSDA molecular association, regulation; intracellular localization carcinogenesis, induced; cell growth, induced; transcription, induced; signaling pathway regulation SUFU(DISRUPTS) 22439934 1 1 0 mTOR/S6K1 and HH-pathways -SSTR2 SSTR2 GPCR, family 1; Membrane protein, integral; Membrane protein, multi-pass; Receptor, GPCR P30874 6752 17q25.1 human T359-p 12577700 ETTETQRtLLNGDLQ receptor internalization, induced; receptor desensitization, induced; receptor recycling, induced 24565897; 24637622 6 0 0 -Kdm6b JMJD3 DEMETHYLASE; Demethylase; EC 1.14.11.-; Oxidoreductase Q5NCY0 216850 11|11 B3 mouse T1044-p 1867766700 GGVSKVKtPTAPAPP molecular association, regulation; intracellular localization autophagy, induced; transcription, induced PPAR-alpha(INDUCES) 32042044 1 1 0 -UBE2I UBC9 EC 6.3.2.-; EC 6.3.2.19; Ligase; Nuclear receptor co-regulator; SUMO LIGASE; SUMO conjugating system; SUMO ligase; UBIQUITIN LIGASE; Ubiquitin conjugating system; Ubiquitin ligase P63279 7329 16p13.3 human K14-sm 4199300 SRLAQERkAWRKDHP UQ_con sumoylation; molecular association, regulation; intracellular localization; enzymatic activity, induced DAXX(INDUCES); IPO13(INDUCES); SP100(INDUCES); RASD2(INDUCES) 18691969; 19635459; 20424159; 21139563 4 1 0 -Mafa MAFA DNA-binding; Oncoprotein; Transcription factor; Tumor suppressor Q8CF90 378435 15|15 D3 mouse T57-p 456028 LSSTPLStPCSSVPS protein degradation; molecular association, regulation transcription, inhibited MAFA(INDUCES); PSME3(INDUCES) DNA(NOT_REPORTED) 20208071; 21646385 8 1 0 -APP APP Apoptosis; Cell surface; Membrane protein, integral; Receptor, misc.; Transcription factor P05067 351 21q21.3 human S697-me 1881129800 FFAEDVGsNKGAIIG molecular association, regulation APP(NOT_REPORTED) 33328587 1 1 0 formaldehyde (FA) cross-linked with K699 residue in the ?-turn of A? monomer to form A? dimers, and then accelerated A? oligomerization -Gja1 GJA1 Channel, misc.; Membrane protein, integral; Membrane protein, multi-pass; Motility/polarity/chemotaxis P08050 24392 20q11 rat S328-p 449993 GQAGSTIsNSHAQPF Connexin43 intracellular localization cell adhesion, induced; cell adhesion, altered; signaling pathway regulation 12270943; 23742896 10 13 0 cardiomyocyte FGF signaling, maintenance of cell-cell gap junctions -TRPV5 TRPV5 Channel, cation; Membrane protein, integral; Membrane protein, multi-pass; Motility/polarity/chemotaxis Q9NQA5 56302 7q34 human S654-p 470109 YVEVFKNsDKEDDQE activity, induced; intracellular localization 17006539 3 0 0 -KCNMA1 KCNMA1 Channel, potassium; Endoplasmic reticulum; Membrane protein, integral; Membrane protein, multi-pass Q28204 282573 cow T139-p 469977 PVDEKEEtVAAEVGW activity, induced 16341213 1 0 0 CAMK2 phosphorylation switches ethanol induced activation of channel to inhibition. -NFATC1 NFAT2 DNA-binding; Transcription factor O95644 4772 18q23 human K914-sm 6413901 APIPVTVkREPEELD molecular association, regulation; intracellular localization chromatin organization, altered; signaling pathway regulation; transcription, inhibited HDAC1(INDUCES); HDAC2(INDUCES); PML(INDUCES); HDAC4(INDUCES) 19218564; 32986812 2 1 0 K702/914R and K349/702/914R mutants prevented sumoylation in mice, increased IL-2 secretion counteracted IL-17 and IFN-gamma expression -TP53 p53 Activator; DNA-binding; Motility/polarity/chemotaxis; Nuclear receptor co-regulator; Transcription factor; Tumor suppressor P04637 7157 17p13.1 human S185-p 1870414701 HHERCSDsDGLAPPQ P53 molecular association, regulation carcinogenesis, induced; transcription, inhibited DNA(DISRUPTS) 32873634 1 0 0 -NR1I2 PXR DNA-binding; Nuclear receptor O75469 8856 3q13.33 human S350-p 4668103 MQAISLFsPDRPGVL Hormone_recep protein degradation; acetylation; molecular association, regulation; ubiquitination; intracellular localization; protein conformation; activity, inhibited transcription, induced; transcription, inhibited; transcription, altered RORA(INDUCES); RXRA(DISRUPTS); FGR(INDUCES); HSP90A(INDUCES); N-CoR1(DISRUPTS); HSP90A(DISRUPTS); HNF4 alpha(INDUCES); DNAJC7(DISRUPTS) 18784074; 19617467; 22829544; 23264496; 26119819; 32798464; 35053380 9 0 0 -CFL1 Cofilin-1 Cytoskeletal; Motility/polarity/chemotaxis; Nuclear receptor co-regulator P23528 1072 11q13.1 human S3-p 448444 _____MAsGVAVSDG activity, induced; molecular association, regulation; intracellular localization; activity, inhibited; phosphorylation cell cycle regulation; carcinogenesis, induced; cell motility, induced; cell growth, inhibited; cell adhesion, induced; cell motility, inhibited; signaling pathway regulation; autophagy, induced; cell growth, induced; apoptosis, inhibited; cell motility, altered; cell adhesion, altered; cytoskeletal reorganization 14-3-3 zeta(INDUCES); CAP1(DISRUPTS) 11171090; 11276226; 11784854; 12361576; 14634665; 14645219; 17113383; 18070928; 18079118; 18771940; 18957424; 19329994; 20190821; 21571222; 21693580; 23737525; 23841590; 23934191; 24664099; 25595902; 25800056; 26169356; 27153537; 29058761; 31791978; 33657382; 34294886; 34675073; 34995286; 35069199; 35132180; 37059490; 8824278 97 69 3 induces mitophagy -PXN PXN iso2 Adaptor/scaffold; Cell adhesion; Cytoskeletal; Motility/polarity/chemotaxis P49023-2 5829 12q24.23 human S244-p 465487 VNQGEMSsPQRVTST Paxillin molecular association, regulation cell differentiation, induced; cytoskeletal reorganization FAK(INDUCES) 18042622 2 6 2 myelination -KCNJ1 ROMK Channel, potassium; Membrane protein, integral; Membrane protein, multi-pass P48048 3758 11q24.3 human S183-p 2813506 GAILAKIsRPKKRAK IRK activity, induced; intracellular localization 12221079 2 0 0 -ARHGAP21 ARHGAP21 GAP; GAP, Rac/Rho Q5T5U3 57584 10p12.1|10p12.3 human K1443-sm 27850501 ELDNVFFkKENVEQC cell growth, induced 22922005 1 1 0 -Hdac5 HDAC5 DEACETYLASE; Deacetylase; EC 3.5.1.98; Hydrolase Q9Z2V6 15184 11|11 D mouse S250-p 447995 FPLRKTAsEPNLKVR molecular association, regulation 14-3-3 epsilon(INDUCES) 11114197 25 23 25 -MORC3 MORC3 Cell cycle regulation; RNA-binding Q14149 23515 21q22.12 human K794-sm 14988617 CSALQHVkAECSQCS molecular association, regulation PML(INDUCES) 20501696 1 0 0 -HNRNPA1 hnRNP A1 Nuclear export; RNA splicing; RNA-binding; Spliceosome P09651 3178 12q13.13 human S6-p 455946 __MSKSEsPKEPEQL sumoylation; molecular association, regulation; intracellular localization RNA splicing, induced; cell growth, induced; apoptosis, inhibited; translation, induced 14-3-3 sigma(INDUCES); 14-3-3 theta(INDUCES) RNA(INDUCES) 25324306; 29344170 2 96 4 interaction with BCL-XL and XIAP mRNA and regulation of their translation; nuclear import/export; glycolysis -H3c1 H3 DNA-binding P68433 360198 13|13 A3.1 mouse K27-m1 465522 LATKAARkSAPATGG Histone endocytosis, altered; chromatin organization, altered; cell differentiation, induced; cell adhesion, altered; transcription, induced 20574709; 33195484 22 20 47 axon guidance -Lmna lamin A/C Cytoskeletal P48679 60374 2q34 rat S404-p 478681 RSRGRASsHSSQSQG activity, induced; protein degradation cell differentiation, induced 18808171; 26045045 8 49 106 nucleus morphology; reduced nuclear size -EIF4E EIF4E Translation; Translation initiation P06730 1977 4q23 human S209-p 447776 DTATKSGsTTKNRFV activity, induced; sumoylation; protein degradation; molecular association, regulation; enzymatic activity, induced carcinogenesis, induced; cell growth, induced; apoptosis, inhibited; translation, induced; cell growth, altered 4E-T(INDUCES); 4E-BP1(DISRUPTS) RNA(INDUCES); RNA(DISRUPTS) 15574771; 16540463; 19934253; 20008839; 25915158; 25923732; 28745319; 31903169; 34012509 64 4 0 -Gorasp2 GRASP55 Motility/polarity/chemotaxis; Vesicle Q9R064 113961 3q22 rat T249-p 2756300 PSLSPPGtAGVEQSL cell cycle regulation 18385516 2 0 1 -RICTOR RICTOR Adaptor/scaffold; Cell cycle regulation; Ubiquitin conjugating system Q6R327 253260 5p13.1 human T1135-p 458276 NRRIRTLtEPSVDFN RICTOR_phospho molecular association, regulation; ubiquitination; phosphorylation 14-3-3 beta(INDUCES); 14-3-3 epsilon(INDUCES); CUL1(DISRUPTS) 19720745; 19935711; 20832730; 22310280 11 14 173 ILK/Rictor complex formation in cancer but not in normal cell types; T1135 phosphorylation reduces Rictor ubiquitination of SGK1. -Tp53 p53 Activator; DNA-binding; Motility/polarity/chemotaxis; Nuclear receptor co-regulator; Transcription factor; Tumor suppressor P10361 24842 10q24 rat K118-ac 474514 FLQSGTAkSVMCTYS P53 molecular association, regulation apoptosis, induced; transcription, induced DNA(DISRUPTS) 24096875 44 8 0 -TNFRSF1B TNF-R2 Membrane protein, integral; Receptor, cytokine P20333 7133 1p36.22 human T436-p 11493000 AFRSQLEtPETLLGS activity, inhibited 9535738 1 0 0 may inhibit activation of NF-kB. -YARS1 YARS Aminoacyl-tRNA synthetase; EC 6.1.1.1; Ligase; Translation; Translation regulation P54577 8565 1p35.1 human K244-ac 62952700 RKEDVKKkLKKAFCE tRNA-synt_1b intracellular localization; enzymatic activity, inhibited; protein conformation DNA repair, induced; transcription, induced 28069943 1 0 0 promotes nuclear translocation, prevents DNA damage by oxidative stress -PDGFRB PDGFRB EC 2.7.10.1; KINASE; Kinase, protein; Membrane protein, integral; Oncoprotein; Protein kinase, TK; Protein kinase, tyrosine (receptor) P09619 5159 5q32 human Y775-p 449964 SSNYMAPyDNYVPSA PK_Tyr_Ser-Thr molecular association, regulation GRB7(INDUCES) 8940081 3 2 2 -H3-3A H3F3A DNA-binding P84243 3020 1q42.12 human S31-p 18545303 AARKSAPsTGGVKKP Histone intracellular localization 37638746 5 6 0 H3.3S31Ph was accumulated at FKBP5 SE during induction in parental cells -Rps6kb1 p70S6K EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, AGC; Protein kinase, Ser/Thr (non-receptor); Translation P67999 83840 10q26 rat T444-p 448358 RFIGSPRtPVSPVKF enzymatic activity, induced 11705993; 15774499 106 37 109 -HNRNPK hnRNP K RNA splicing; RNA-binding; Spliceosome P61978 3190 9q21.32 human R258-m2 6742805 VGFPMRGrGGFDRMP molecular association, regulation translation, inhibited RPS19(INDUCES) 33660773 2 3 1 suppression of ALOX15 mRNA translation initiation -PACS2 PACS2 Q86VP3 23241 14q32.33 human S208-p 1884003502 EEYESFSsEQEASDD intracellular localization 37523531 1 0 0 -KCND3 Kv4.3 Channel, potassium; Membrane protein, integral; Membrane protein, multi-pass Q9UK17 3752 1p13.2 human T504-p 11139168 LLSVRTStIKNHEFI DUF3399 activity, inhibited 28919864 1 0 1 -Dgkg DGKG EC 2.7.1.107; Kinase, lipid; Lipid Metabolism - glycerolipid; Lipid Metabolism - glycerophospholipid; Motility/polarity/chemotaxis P49620 25666 11q23 rat S776-p 471077 MGPPQKSsFFSLRRK enzymatic activity, induced 16905533 1 0 0 -DNM2 DYN2 EC 3.6.5.5; Hydrolase; Microtubule-binding; Motility/polarity/chemotaxis; Vesicle P50570 1785 19p13.2 human T766-p 452323 SASSHSPtPQRRPVS molecular association, regulation 20889493 1 7 0 reduces microtubule-binding activity of DYN2 -Rin1 Rin1 GEF; GEF, Rab Q921Q7 225870 19|19 A mouse Y147-p 2796500 LVQLICGyCRTRAIH molecular association, regulation Arg(INDUCES) 15886098 1 0 0 -ARHGAP24 ARHGAP24 GAP; GAP, Rac/Rho; Motility/polarity/chemotaxis Q8N264 83478 4q21.23-q21.3 human S402-p 4757006 LSGSKTNsPKNSVHK activity, induced cytoskeletal reorganization 16862148 2 8 0 membrane blebbing -Spry2 SPRY2 Adaptor/scaffold; Inhibitor; Motility/polarity/chemotaxis Q9QXV8 24064 14 E2.3|14 56.16 cM mouse Y55-p 448849 AIRNTNEyTEGPTVV activity, induced; molecular association, regulation; activity, inhibited GRB2(INDUCES); CBL(INDUCES) 12402043; 15004239 10 6 89 -JAK3 JAK3 EC 2.7.10.2; KINASE; Kinase, protein; Protein kinase, TK; Protein kinase, tyrosine (non-receptor) P52333 3718 19p13.11 human Y981-p 447637 LPLDKDYyVVREPGQ PK_Tyr_Ser-Thr enzymatic activity, inhibited 9391116 6 3 2 -SKA3 SKA3 Cell cycle regulation Q8IX90 221150 13q12.11 human T360-p 459963 ENLLRTPtPPEVTKI molecular association, regulation; intracellular localization cell cycle regulation; cell growth, induced; chromatin organization, altered; cytoskeletal reorganization PLK1(INDUCES); HEC1(INDUCES) 28479321; 32491969; 33106477 3 8 11 regulation of Akt phosphorylation via PLK1, regulation of SKA3 glycolytic activity -GPRC5A RAIG1 GPCR, family 3; Membrane protein, integral; Membrane protein, multi-pass; Receptor, GPCR Q8NFJ5 9052 12p13.1 human Y317-p 451750 EETGDTLyAPYSTHF cell growth, induced 25311788 1 12 292 Tyrosine phosphorylation inhibits the suppressive effect of RAIG1 on cell invasion and anchorage-independent growth. -Rab3ip RAB3IP GEF; GEF, Rab Q62739 29885 7q22 rat S16-p 37039802 FHEVNLAsPTSPDLL activity, induced; molecular association, regulation; protein conformation; enzymatic activity, induced exocytosis, induced RAB11A(DISRUPTS); RAB8A(INDUCES) 25535387 1 0 0 induces GEF activity of RAB3IP, induces RAB8 activity -FLT3 FLT3 EC 2.7.10.1; KINASE; Kinase, protein; Membrane protein, integral; Oncoprotein; Protein kinase, TK; Protein kinase, tyrosine (receptor) P36888 2322 13q12.2 human Y589-p 448189 TGSSDNEyFYVDFRE molecular association, regulation; enzymatic activity, inhibited; phosphorylation cell growth, altered Src(INDUCES) 11971190; 16627759; 16684964 6 0 1 The double mutation Y589/591F has a slower growth rate (this is in the ligand-independent, constitutive active allele). -GATA6 GATA6 Motility/polarity/chemotaxis; Transcription factor Q92908 2627 18q11.2 human S266-p 2833503 VSARFPYsPSPPMAN GATA-N transcription, induced; cell growth, altered 18454176 2 3 3 -ITGB1 ITGB1 Cell adhesion; Cell surface; Membrane protein, integral; Motility/polarity/chemotaxis; Receptor, misc. P05556 3688 10p11.22 human Y783-p 447710 DTGENPIyKSAVTTV Integrin_b_cyt molecular association, regulation; intracellular localization tensin 1 iso1(INDUCES) 17473008 7 42 1183 preference for the first, membrane-proximal, NPxY motif; phosphorylation does not seem to affect tensin binding; however, in vivo, tensin competes with talin which prefers non-phosphorylated sites -HSP90AA1 HSP90A Chaperone; Heat shock protein P07900 3320 14q32.31 human K546-ac 479635 KTLVSVTkEGLELPE HSP90 molecular association, regulation CHIP(DISRUPTS); TEBP(DISRUPTS); HSP70(DISRUPTS); HSP40(DISRUPTS) 18559531 1 3 2 -ZBTB16 PLZF C2H2-type zinc finger protein; DNA-binding; Oncoprotein; Transcription, coactivator/corepressor Q05516 7704 11q23.2 human K396-sm 2303902 GELAVGMkSESRTIG cell growth, inhibited; transcription, inhibited 17498654 1 0 0 -LAX1 LAX1 Adaptor/scaffold; Membrane protein, integral Q8IWV1 54900 1q32.1 human Y294-p 35546001 AFQCCRDyENVPAAD LAX molecular association, regulation transcription, inhibited; signaling pathway regulation GRB2(INDUCES); GADS(INDUCES); PIK3R1(INDUCES) 12359715 1 0 0 -IL6ST gp130 Membrane protein, integral; Receptor, cytokine P40189 3572 5q11.2 human K849-ub 964517458 EEDFVRLkQQISDHI receptor internalization, induced; protein degradation transcription, inhibited 34785732 1 1 0 In IL6R K401R and gp130 K849R mutants, IL-6-induced transcription of downstream genes compared to wild-type receptors. -LRP2 LRP2 Membrane protein, integral; Motility/polarity/chemotaxis; Receptor, misc. P98164 4036 2q31.1 human S4616-p 767904 VAATPPPsPSLPAKP receptor internalization, altered; receptor recycling, altered 17555532 1 7 0 -Tiam2 TIAM2 Apoptosis; GEF; GEF, Rac/Rho Q6ZPF3 24001 17 A1|17 1.99 cM mouse T749-p 15503728 DSTLRKRtLSLTQRG cell growth, induced; cytoskeletal reorganization; signaling pathway regulation 21460187 1 0 0 induces PKA/TIAM2/RAC1 pathway and neurite outgrowth -NF1 NF1 iso2 GAP; GAP, Ras; Motility/polarity/chemotaxis; Nucleolus; Tumor suppressor P21359-2 4763 17q11.2 human S2580-p 456017 RKVSVSEsNVLLDEE molecular association, regulation; activity, inhibited 14-3-3 beta(INDUCES) 14741381 1 1 0 -Cish CISH O70512 83681 8q32 rat K71-ub 37044805 GDLLCIAkTFSYLRE protein degradation 25448846 1 0 0 -TRIM29 TRIM29 Transcription factor; UBIQUITIN LIGASE; Ubiquitin ligase Q14134 23650 11q23.3 human S552-p 27457998 PSLMRSQsPKAQPQT apoptosis, inhibited 24469230 1 2 0 radioresistance -Coro1a coronin 1A Cytoskeletal; Motility/polarity/chemotaxis O89053 12721 7 69.25 cM|7 F3 mouse S2-p 14571846 ______MsRQVVRSS intracellular localization exocytosis, altered; cytoskeletal reorganization 21844203 2 1 0 inhibits MC (mast cells) degranulation -LATS1 LATS1 EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, AGC; Protein kinase, Ser/Thr (non-receptor); Tumor suppressor O95835 9113 6q25.1 human S872-p 1791604 GDHPRQDsMDFSNEW Pkinase protein degradation; intracellular localization; phosphorylation carcinogenesis, inhibited; signaling pathway regulation 31239271 2 2 2 induces phosphorylation, localization and degradation of YAP, inhibits YAP signaling mediated carcinogenesis -NCBP1 NCBP1 RNA processing; Spliceosome; Translation Q09161 4686 9q22.33 human T21-p 480103 QPHKRRKtSDANETE RNA splicing, altered 10973943 1 28 68 -FOXM1 FOXM1 iso2 DNA-binding; Transcription factor Q08050-2 2305 12p13.33 human K201-sm 31898500 GLGSRSIkQEMEEKE protein degradation transcription, inhibited 25533473 2 1 0 -GLE1 GLE1 Karyopherin; Nuclear export Q53GS7 2733 9q34.11 human S93-p 31084897 PKSPDASsAFSPASP molecular association, regulation GLE1(INDUCES) 30429220 1 2 0 self-association stress granules' assembly and disassembly, DDX3-ATPase activity inhibited -SCN5A SCN5A Channel, sodium; Membrane protein, integral; Membrane protein, multi-pass Q14524 6331 3p22.2 human S483-p 3799151 SKRRKRMsSGTEECG protein conformation 33410863 4 6 4 -FLT1 VEGFR1 EC 2.7.10.1; KINASE; Kinase, protein; Membrane protein, integral; Protein kinase, TK; Protein kinase, tyrosine (receptor) P17948 2321 13q12.3 human Y1242-p 448210 ATSMFDDyQGDSSTL cell cycle regulation; cell growth, altered 11583921 2 1 2 mutation to phenylalanine caused increased tyrosine phosphorylation of PLCG1 -AVPR2 AVPR2 GPCR, family 1; Membrane protein, integral; Membrane protein, multi-pass; Receptor, GPCR; Transporter; Transporter, aquaporin family P30518 554 Xq28 human S363-p 451068 ESCTTASsSLAKDTS intracellular localization; receptor recycling, altered 11150299; 9482866 2 0 0 After receptor activation, phosphorylation of serines 362, 363, and 364 inhibits overall dephosphorylation of the internalized receptor, thereby inhibiting recycling of the receptor to the cell surface. -WNK3 WNK3 EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, Other; Protein kinase, Ser/Thr (non-receptor) Q9BYP7 65267 Xp11.22 human T541-p 1876335000 TGAECEEtEVDQHVR molecular association, regulation KLHL3(DISRUPTS) 35179207 1 0 0 -Npm1 NPM1 Nucleolus; Oncoprotein; RNA-binding; Translation Q61937 18148 11|11 A4 mouse S125-p 459897 AVEEDAEsEDEDEED intracellular localization; protein conformation; phosphorylation carcinogenesis, induced; cell motility, induced; cell growth, induced; apoptosis, inhibited; signaling pathway regulation 24616519; 32606971 11 95 558 induces ERK phosphorylation and NFKB translocation thus inducing ERK/NF-K? signaling -CERS6 LASS6 DNA-binding; Membrane protein, integral; Membrane protein, multi-pass Q6ZMG9 253782 2q24.3 human S346-p 22350309 DRSDIESsSDEEDSE enzymatic activity, induced 26887952 1 3 0 -CYTH1 cytohesin 1 GEF; GEF, ARF; Motility/polarity/chemotaxis Q15438 9267 17q25.3 human T395-p 1319400 RKKKVSStKRH____ activity, induced 18042453 1 0 0 increase in exchange activity, GRP1 autoinhibition reversed -CREB1 CREB DNA-binding; Transcription factor P16220 1385 2q33.3 human S256-p 3181028 APGVVMAsSPALPTQ molecular association, regulation cell cycle regulation; transcription, inhibited DNA(DISRUPTS) 23814058 1 2 0 promotes dissociation from chromatin -NCF1 p47phox EC 1.-.-.-; Oxidoreductase P14598 653361 7q11.23 human S303-p 449405 RGAPPRRsSIRNAHS NECFESHC activity, induced; molecular association, regulation; enzymatic activity, induced CYBA(INDUCES) 10559253; 12056906 9 0 0 -PDK1 PDHK1 EC 2.7.11.2; KINASE; Kinase, protein; Mitochondrial; Protein kinase, Ser/Thr (non-receptor); Protein kinase, atypical Q15118 5163 2q31.1 human Y243-p 462384 ARRLCDLyYINSPEL intracellular localization 22195962 2 1 2 localized to mitochondria in cancer cells -PTEN PTEN Carbohydrate Metabolism - inositol phosphate; EC 3.1.3.16; EC 3.1.3.48; EC 3.1.3.67; Motility/polarity/chemotaxis; Nuclear receptor co-regulator; PHOSPHATASE; Phosphatase, lipid; Tumor suppressor P60484 5728 10q23.31 human S113-p 33636428 EDLDQWLsEDDNHVA intracellular localization autophagy, induced 25701194 1 0 1 nuclear translocation -CHMP4C CHMP4C Vesicle Q96CF2 92421 8q21.13 human S210-p 25123900 MSSTARRsRAASSQR molecular association, regulation; intracellular localization cell cycle regulation VPS4B(INDUCES); VPS4A(INDUCES) 22422861; 22724069; 29362225; 30905608 4 0 0 high cytokinetic cells; mutations of site increase cytokinesis failure -CSRP1 CSRP1 Cytoskeletal; Motility/polarity/chemotaxis P21291 1465 1q32.1 human Y57-p 2091906 AVHGEEIyCKSCYGK LIM intracellular localization 12802285 1 2 8 -CORO7 coronin 7 Vesicle P57737 79585 16p13.3 human Y712-p 1871177706 SERQLLLyEAEALAG phosphorylation signaling pathway regulation 33162394 1 0 0 inhibits phosphorylation of YAP7 and hence the Hippo signaling pathway -IRS2 IRS2 Adaptor/scaffold; Motility/polarity/chemotaxis Q9Y4H2 8660 13q34 human S388-p 1984212 RPVSVAGsPLSPGPV activity, inhibited 34731634 1 30 32 -Rela NFkB-p65 DNA-binding; Nuclear receptor co-regulator; Transcription factor Q04207 19697 19 A|19 4.34 cM mouse S467-p 451145 GVFTDLAsVDNSEFQ protein degradation; ubiquitination transcription, induced; translation, induced; transcription, inhibited COMMD1(INDUCES); CUL2(INDUCES) 19270718; 28723419 22 0 0 regulate locomotor activity and energy expenditure; TNF induced degradation -AKT1 Akt1 EC 2.7.11.1; KINASE; Kinase, protein; Oncoprotein; Protein kinase, AGC; Protein kinase, Ser/Thr (non-receptor) P31749 207 14q32.33 human K14-m1 58948913 VKEGWLHkRGEYIKT PH activity, induced; intracellular localization; phosphorylation cell growth, induced 27626683 1 0 0 -RAC1 RAC1 G protein; G protein, monomeric; G protein, monomeric, Rho; Motility/polarity/chemotaxis P63000 5879 7p22.1 human K5-ub 573766214 ___MQAIkCVVVGDG Ras carcinogenesis, inhibited; signaling pathway regulation 35858925 1 1 0 RAC1-MAPK signaling axis, Trim72 signi?cantly inhibited the tumorigenesis of HCC i -FHL2 FHL2 Motility/polarity/chemotaxis; Nuclear receptor co-regulator; Transcription, coactivator/corepressor Q14192 2274 2q12.2 human Y217-p 1873117006 LNCFCDLyAKKCAGC LIM cell cycle regulation; cell growth, inhibited 33932144 1 1 0 -Net1 NET1 GEF; GEF, Rac/Rho; Motility/polarity/chemotaxis; Oncoprotein Q9Z206 56349 13|13 A1 mouse Y427-p 1881982104 ERHLYQVyRQPIPVQ intracellular localization cell motility, induced; cytoskeletal reorganization; signaling pathway regulation 37271338 1 1 0 induces EGF-stimulated RhoA signaling -Disc1 DISC1 Cell development/differentiation; Motility/polarity/chemotaxis Q811T9 244667 8 E2|8 73.26 cM mouse K640-sm 62504401 SRRLGIVkEDHLRCR intracellular localization cell growth, induced 27525255 1 0 0 -MFF MFF Membrane protein, integral; Mitochondrial Q9GZY8 56947 2q36.3 human S155-p 470753 GRLKRERsMSENAVR Miff ubiquitination cell cycle regulation; carcinogenesis, induced; cell growth, induced; transcription, induced 34010649; 35316673 4 43 91 inhibits ubiquitination and induces stability of Cyclin B1; induce VDAC1 oligomerization -RAD18 RAD18 DNA repair, damage; EC 6.3.2.-; EC 6.3.2.19; Ligase; UBIQUITIN LIGASE; Ubiquitin conjugating system; Ubiquitin ligase Q9NS91 56852 3p25.3 human S434-p 17595902 IQEVLSSsESDSCNS molecular association, regulation POLQ(INDUCES) 21098111 2 0 0 promotes POLQ recruitment to stalled replication forks -PIAS1 PIAS1 EC 6.3.2.-; Nuclear receptor co-regulator; SUMO LIGASE; SUMO conjugating system; SUMO ligase; Transcription, coactivator/corepressor O75925 8554 15q23 human K30-ub 53747700 LGYAGRNkHGRKHEL protein degradation translation, inhibited 26157031 1 0 0 -MAX MAX DNA-binding; Transcription factor P61244 4149 14q23.3 human S11-p 449308 NDDIEVEsDEEQPRF molecular association, regulation; activity, inhibited transcription, altered DNA(DISRUPTS) 37642402; 8018564 5 28 0 phosphorylation-deficient mutant inhibits transcription more efficiently -Zap70 ZAP70 EC 2.7.10.2; KINASE; Kinase, protein; Protein kinase, TK; Protein kinase, tyrosine (non-receptor) P43404 22637 1 B|1 15.41 cM mouse Y492-p 447505 LGADDSYyTARSAGK PK_Tyr_Ser-Thr intracellular localization; enzymatic activity, induced signaling pathway regulation 15699109; 34452999 28 13 427 weak enzymatic activation; regulates TCR signaling -NFE2L2 NRF2 DNA-binding; Transcription factor Q16236 4780 2q31.2 human S344-p 18258505 AEFNDSDsGISLNTS protein degradation; molecular association, regulation; ubiquitination transcription, inhibited BTRC(INDUCES) 22751928; 32295843 4 1 0 -RB1 Rb Nuclear receptor co-regulator; Oncoprotein; Transcription, coactivator/corepressor; Tumor suppressor P06400 5925 13q14.2 human R798-m2 36533406 KFPSSPLrIPGGNIY Rb_C phosphorylation cell cycle regulation; transcription, inhibited 25348716 1 0 0 -PDCD6IP Alix Adaptor/scaffold; Apoptosis Q8WUM4 10015 3p22.3 human K501-ub 3935334 NFRTVLDkAVQADGQ ALIX_LYPXL_bnd molecular association, regulation; ubiquitination 30760577 1 8 16 interaction with Gag and Alix -Oprm1 MOR-1 GPCR, family 1; Membrane protein, integral; Membrane protein, multi-pass; Receptor, GPCR P33535 25601 1q11 rat S363-p 447783 STIEQQNsTRVRQNT molecular association, regulation; receptor desensitization, altered; receptor internalization, altered ARR3(INDUCES); ARRB2(INDUCES) 11278523; 18558479; 23106126 11 6 0 -THRB TR-beta1 DNA-binding; Nuclear receptor P10828 7068 3p24.2 human Y406-p 976541 FLLAFEHyINYRKHH Hormone_recep activity, induced; protein degradation carcinogenesis, inhibited; cell growth, inhibited; signaling pathway regulation 25275301; 27254276 2 1 0 cSrc-FAK-KRAS-ERK signaling; induce TR-beta1 degradation and decreased src signaling; TR-beta1Y406F loses tumor supressor function -Errfi1 MIG-6 Inhibitor; Tumor suppressor P05432 313729 5q36 rat S250-p 3215403 RRLRRSHsGPAGSFN protein stabilization; molecular association, regulation 14-3-3 theta(INDUCES) 23432726 3 41 39 -PTEN PTEN Carbohydrate Metabolism - inositol phosphate; EC 3.1.3.16; EC 3.1.3.48; EC 3.1.3.67; Motility/polarity/chemotaxis; Nuclear receptor co-regulator; PHOSPHATASE; Phosphatase, lipid; Tumor suppressor P60484 5728 10q23.31 human K66-ub 27205468 SKHKNHYkIYNLCAE protein degradation; ubiquitination 27405757; 30631154 3 3 0 PTEN dephosphorylates master regulators of EMT in vivo; K27-linked polyubiquitination alters PTEN substrate binding; converted PTEN from a phosphoinositide/protein tyrosine phosphatase to a protein serine/threonine phosphatase -SCFD1 SCFD1 Vesicle Q8WVM8 23256 14q12 human K126-ac 38507606 ISAISRSkLEDIANA Sec1 autophagy, inhibited 35465820 1 1 2 SCFD1 deacetylation promotes SNARE complex formation -Cops3 COPS3 Ubiquitin conjugating system O88543 26572 11|11 B1.3 mouse S410-p 482300 FVQKSMGsQEDDSGN DNA repair, induced 25855810 1 18 2 -H3c1 H3 DNA-binding P68433 360198 13|13 A3.1 mouse K23-m1 7836400 PRKQLATkAARKSAP Histone chromatin organization, altered 19434510 0 4 19 regulation of senescence-related epigenetics modification -TP53BP2 53BP2 Transcription, coactivator/corepressor Q13625 7159 1q41 human Y869-p 36747002 YLEEYPPyPPPPYPS protein degradation; molecular association, regulation; intracellular localization; phosphorylation transcription, induced 53BP2(INDUCES) 25360797 1 0 0 promotes the dephosphorylation of YAP -Gap43 GAP43 Cell surface P06837 14432 16 B4|16 28.37 cM mouse S41-p 448719 AATKIQAsFRGHITR IQ cell growth, altered 16522636 14 9 5 -STYK1 STYK1 EC 2.7.10.2; KINASE; Kinase, protein; Membrane protein, integral; Oncoprotein; Protein kinase, TK; Protein kinase, tyrosine (non-receptor); Protein kinase, tyrosine (receptor) Q6J9G0 55359 12p13.2 human Y191-p 1869546304 CTEKLPLyMVLEDVA PK_Tyr_Ser-Thr molecular association, regulation; phosphorylation; enzymatic activity, induced STYK1(INDUCES); PIK3R4(INDUCES); PIK3C3(INDUCES); ATG14(INDUCES) 31696776 1 0 0 induces formation of PtdIns3K-C1 complex -Cnr1 CNR1 GPCR, family 1; Membrane protein, integral; Membrane protein, multi-pass; Receptor, GPCR P20272 25248 5q21 rat T314-p 3989689 VRMIQRGtQKSIIIH 7tm_1 exocytosis, inhibited 33582301 1 3 1 -PHLPP1 PHLPP EC 3.1.3.16; PHOSPHATASE; Protein phosphatase, Ser/Thr (non-receptor); Tumor suppressor O60346 23239 18q21.33 human S323-p 31884076 ASPAPSDsSPGEPFV cell cycle regulation 33397691 1 2 0 -PBXIP1 PBXIP1 Cytoskeletal Q96AQ6 57326 1q21.3 human K274-ub 15394414 NMGLLLDkLAKENQD protein degradation; ubiquitination cell cycle regulation 31101654; 34716429 2 0 3 regulation of the G2/M transition -Prkcb PKCB iso2 EC 2.7.11.13; KINASE; Kinase, protein; Motility/polarity/chemotaxis; Protein kinase, AGC; Protein kinase, Ser/Thr (non-receptor) P68404-2 18751 7 F2|7 65.75 cM mouse S660-p 1869073011 QSEFEGFsFVNSEFL Pkinase_C molecular association, regulation mTOR(DISRUPTS) 33850054 14 34 140 -Ceacam1 CEACAM1 Cell adhesion; Immunoglobulin superfamily; Membrane protein, integral; Motility/polarity/chemotaxis P31809 26365 7 A3|7 13.84 cM mouse S503-p 448536 QQPNRPTsAPSSPRA molecular association, regulation cell growth, altered SHC1(INDUCES) 11694516 11 2 0 -MAPK3 ERK1 iso3 EC 2.7.11.24; KINASE; Kinase, protein; Protein kinase, CMGC; Protein kinase, Ser/Thr (non-receptor) P27361-3 5595 16p11.2 human S343-p 50703500 PTDEVGQsPAAVGLG molecular association, regulation; intracellular localization; enzymatic activity, induced cell growth, induced 14-3-3 gamma(INDUCES); PIK4CB(INDUCES) 26459638 1 0 0 translocated to the Golgi in mitosis -PLK1 PLK1 EC 2.7.11.21; KINASE; Kinase, protein; Protein kinase, Other; Protein kinase, Ser/Thr (non-receptor) P53350 5347 16p12.2 human S330-p 4271242 PRFSIAPsSLDPSNR molecular association, regulation cell cycle regulation 14-3-3 zeta(INDUCES) 22202082; 23046929 2 0 0 -Irs1 IRS1 Adaptor/scaffold; Motility/polarity/chemotaxis P35570 25467 9q34 rat S1100-p 453434 GCRRRHSsETFSAPT activity, inhibited 17709744; 36224569 13 39 122 -DEPTOR DEPTOR Apoptosis Q8TB45 64798 8q24.12 human S283-p 4723843 VRRSSMSsCGSSGYF protein degradation; molecular association, regulation carcinogenesis, induced; apoptosis, inhibited; signaling pathway regulation mTOR(DISRUPTS) 19446321 2 2 0 PI3K-Akt signaling -MALT1 MALT1 Adaptor/scaffold; Apoptosis; EC 3.4.22.-; Ligase; Nuclear export; Protease; UBIQUITIN LIGASE; Ubiquitin conjugating system Q9UDY8 10892 18q21.32 human S814-p 1870751203 TTDEIPFsFSDRLRI carcinogenesis, induced; cell growth, induced; transcription, induced; signaling pathway regulation 31644910 1 1 0 activates transcription of NF-kB -MAPK8 JNK1 EC 2.7.11.24; KINASE; Kinase, protein; Protein kinase, CMGC; Protein kinase, Ser/Thr (non-receptor) P45983 5599 10q11.22 human K68-ub 573764264 FQNQTHAkRAYRELV Pkinase activity, inhibited; phosphorylation transcription, inhibited MKK7(DISRUPTS) 28753655 1 3 0 phosphorylation inhibited -FBXL20 FBXL20 UBIQUITIN LIGASE; Ubiquitin ligase Q96IG2 84961 17q12 human S421-p 467840 APVTPPPsVGGSRQR protein degradation; molecular association, regulation carcinogenesis, inhibited; cell growth, inhibited; apoptosis, induced FBXO31(INDUCES) 34587475 1 28 9 -CLDN16 Claudin-16 Cell adhesion; Membrane protein, integral; Membrane protein, multi-pass Q9Y5I7 10686 3q28 human S147-p 32001600 VDVYVERsTLVLHNI PMP22_Claudin molecular association, regulation; intracellular localization endocytosis, induced STX8(INDUCES) 24659781; 28623232 2 0 0 -PDGFRB PDGFRB EC 2.7.10.1; KINASE; Kinase, protein; Membrane protein, integral; Oncoprotein; Protein kinase, TK; Protein kinase, tyrosine (receptor) P09619 5159 5q32 human Y751-p 447508 SKDESVDyVPMLDMK PK_Tyr_Ser-Thr activity, induced; molecular association, regulation; protein conformation; enzymatic activity, induced cell cycle regulation; signaling pathway regulation PIK3C2A(INDUCES); SHC1(INDUCES); SHP-1(INDUCES); PIK3R1(INDUCES); PIK3CA(INDUCES) 1314164; 1330535; 1375321; 17403678; 25257795; 7774014; 7935391; 8195171; 8290276; 9452499 26 4 6 -Slc2a2 GLUT2 Membrane protein, integral; Membrane protein, multi-pass; Transporter; Transporter, SLC family P12336 25351 2q24 rat S501-p 451345 AAEFRKKsGSAPPRK activity, inhibited 8626492 1 1 0 Phosphorylation reduces the initial rate of 3-O-methyl glucose uptake. -WAS WASP Adaptor/scaffold; Motility/polarity/chemotaxis P42768 7454 Xp11.23 human Y291-p 447985 AETSKLIyDFIEDQG PBD activity, induced; molecular association, regulation cell motility, altered; cytoskeletal reorganization WIPF1(NOT_REPORTED) 10068673; 12235133; 17890224; 19808890 12 35 657 -Ptpra PTPRA EC 3.1.3.48; Membrane protein, integral; Motility/polarity/chemotaxis; PHOSPHATASE; Receptor protein phosphatase, tyrosine P18052 19262 2 F1|2 63.23 cM mouse Y825-p 447613 YIDAFSDyANFK___ molecular association, regulation; enzymatic activity, induced GRB2(INDUCES); Src(INDUCES) 12834342; 17507376; 7518772 17 85 2339 -ACAT1 ACAT1 ACETYLTRANSFERASE; Acetyltransferase; Amino Acid Metabolism - lysine degradation; Amino Acid Metabolism - tryptophan; Amino Acid Metabolism - valine, leucine and isoleucine degradation; Carbohydrate Metabolism - butanoate; Carbohydrate Metabolism - propanoate; Carbohydrate Metabolism - pyruvate; EC 2.3.1.9; Lipid Metabolism - fatty acid; Lipid Metabolism - synthesis and degradation of ketone bodies; Mitochondrial; Secondary Metabolites Metabolism - terpenoid backbone biosynthesis P24752 38 11q22.3 human Y407-p 10943316 HALKQGEyGLASICN Thiolase_C activity, induced; protein stabilization; protein conformation carcinogenesis, induced; cell growth, induced 27867011 2 1 0 tetramer accumulation -Mybl2 B-Myb DNA-binding; Motility/polarity/chemotaxis; Transcription factor P48972 17865 2 H2|2 84.0 cM mouse T490-p 452027 SQKVVVTtPLHRDKT Cmyb_C activity, induced 9840932 3 2 43 -HACE1 HACE1 EC 6.3.2.-; EC 6.3.2.19; Ligase; UBIQUITIN LIGASE; Ubiquitin conjugating system; Ubiquitin ligase Q8IYU2 57531 6q16.3 human S385-p 10940679 LMKNKRDsTEITSIL protein conformation 29362425 1 9 0 inhibits ubiquitination, S385 modulates HACE1 homo-oligomerization properties -STAR STAR Carrier; Lipid-binding; Mitochondrial P49675 6770 8p11.23 human S57-p 450440 NQVRRRSsLLGSRLE molecular association, regulation; protein conformation 14-3-3 sigma(INDUCES); 14-3-3 epsilon(INDUCES); 14-3-3 gamma(INDUCES) 32633081 5 1 1 -KRT8 K8 Cytoskeletal P05787 3856 12q13.13 human K472-ac 1983601 KIETRDGkLVSESSD cytoskeletal reorganization 18203277; 18983182 2 4 13 -LGR5 LGR5 GPCR, family 1; Membrane protein, integral; Membrane protein, multi-pass; Receptor, GPCR O75473 8549 12q21.1 human S861-p 27806301 SDDVEKQsCDSTQAL receptor internalization, induced 23439653 1 0 0 constitutive internalization. Sites S844, S848, S851 and S854 may secondarily contribute to LGR5 internalization. -FSCN1 fascin Actin-binding; Cytoskeletal; Motility/polarity/chemotaxis Q16658 6624 7p22.1 human S274-p 63292500 AANERNVsTRQGMDL Fascin cell growth, inhibited; cytoskeletal reorganization 28251354 1 0 0 negatively regulates esophageal squamous cancer cells (ESCCs) behavior and ?lopodia formation -Tnni3 TNNI3 Actin-binding; Motility/polarity/chemotaxis; Motor P23693 29248 1q12 rat S45-p 450691 KKSKISAsRKLQLKT cell motility, altered 16936010 22 3 0 heart contractility and relaxation -KIF2A KIF2A Microtubule-binding; Motor O00139 3796 5q12.1 human T97-p 27451648 KIVKNRRtVASIKND intracellular localization cell cycle regulation; cytoskeletal reorganization 23960144 1 4 4 -RECQL4 RECQL4 EC 3.6.4.12; Helicase O94761 9401 8q24.3 human K386-ac 7106306 WKQKWRKkGECFGGG intracellular localization 19299466 1 0 0 accumulates in the cytoplasm -EGFR EGFR EC 2.7.10.1; KINASE; Kinase, protein; Membrane protein, integral; Oncoprotein; Protein kinase, TK; Protein kinase, tyrosine (receptor) P00533 1956 7p11.2 human K1182-ac 14991104 DFFPKEAkPNGIFKG receptor internalization, induced; phosphorylation endocytosis, induced; signaling pathway regulation 20513767 1 1 0 induces AKT phosphorylation and hence ERK1/2 signaling -NLRP3 NLRP3 Inhibitor Q96P20 114548 1q44 human S5-p 38492201 ___MKMAsTRCKLAR protein stabilization; molecular association, regulation; protein conformation; activity, inhibited signaling pathway regulation NLRP3(DISRUPTS); PYCARD(DISRUPTS) 28465465; 32929041 4 1 0 inhibits ubiquitination, inhibits NLRP3 oligomerization -APBA3 APBA3 Motility/polarity/chemotaxis O96018 9546 19p13.3 human T5-p 29668010 ___MDFPtISRSPSG molecular association, regulation cell growth, induced HIF1AN(INDUCES) 24164895 1 1 0 -LIN28A LIN28A Nucleolus; RNA-binding; Translation Q9H9Z2 79727 1p36.11 human S200-p 7231811 EEEEEIHsPTLLPEA activity, inhibited cell growth, inhibited; cell differentiation, induced 28179426 1 5 0 increase in let7a and let7g miRNA and decrease in cyclin D1 levels -Rph3a rabphilin 3A Vesicle P47709 171039 12q16 rat S274-p 455801 QGLRRANsVQASRPA intracellular localization 11466418 3 5 0 -Hmga2 HMGA2 DNA-binding; Oncoprotein P52927 15364 10 D2|10 67.94 cM mouse S44-p 4033091 QEPTCEPsPKRPRGR molecular association, regulation; protein conformation DNA(DISRUPTS) 10636877 1 34 2 -Ffar4 GPR120 GPCR, family 1; Lipid-binding; Membrane protein, integral; Membrane protein, multi-pass; Receptor, GPCR Q7TMA4 107221 19|19 C2 mouse S357-p 31014806 SVRRNDLsVISS___ receptor internalization, induced; molecular association, regulation ARR3(INDUCES) 26873857 3 1 0 -MAML1 MAML1 Transcription, coactivator/corepressor Q92585 9794 5q35.3 human K189-ac 206216901 GLDSLNKkRLADSSL molecular association, regulation Notch 1(INDUCES) 28625977 1 0 0 -Stxbp5 STXBP5 Vesicle Q8K400 78808 10|10 A1 mouse K766-sm 31957309 LSLPTDLkPDLDVKD neural plasticity 24614299 1 0 0 -BMF BMF Apoptosis; Cytoskeletal Q96LC9 90427 15q15.1 human S77-p 22999100 TQTLSPAsPSQGVML BMF apoptosis, inhibited 22258404 2 0 0 -SREBF1 SREBP-1 DNA-binding; Membrane protein, integral; Membrane protein, multi-pass; Transcription factor P36956 6720 17p11.2 human K333-ac 459102 TAHNAIEkRYRSSIN HLH protein stabilization; ubiquitination transcription, induced 12640139; 20595232 2 0 0 -Rplp2 RPLP2 Ribosomal; Translation P02401 140662 1q41 rat S102-p 454319 KDEKKEEsEESDDDM Ribosomal_60s activity, induced translation, altered 12379128 3 120 344 -PXN PXN Adaptor/scaffold; Cell adhesion; Cytoskeletal; Motility/polarity/chemotaxis P49023 5829 12q24.23 human Y88-p 448909 PQSSSPVyGSSAKTS Paxillin carcinogenesis, induced; cell motility, induced; cell growth, induced; cytoskeletal reorganization 35297710 6 48 1343 -AR AR DNA-binding; Nuclear receptor; Transcription factor P10275 367 Xq12 human K521-sm 2793918 YPSPTCVkSEMGPWM molecular association, regulation; activity, inhibited carcinogenesis, induced; transcription, induced; transcription, inhibited RAI17(INDUCES) DNA(INDUCES) 11121022; 12177000; 14609956; 15031320; 32948192 7 0 0 chromatin enrichment independent of ligand activation -MET Met EC 2.7.10.1; KINASE; Kinase, protein; Membrane protein, integral; Oncoprotein; Protein kinase, TK; Protein kinase, tyrosine (receptor) P08581 4233 7q31.2 human Y1235-p 448471 DMYDKEYySVHNKTG PK_Tyr_Ser-Thr activity, induced; protein conformation; phosphorylation; enzymatic activity, induced carcinogenesis, induced; cell motility, induced; cell motility, altered; apoptosis, inhibited; signaling pathway regulation; cell growth, altered PTP1B(INDUCES); PTPN2(INDUCES) 10490849; 12746450; 14559966; 1655790; 18819921; 21247903; 21918175; 22081023; 24634221; 7961992; 8302603 52 16 442 -CALD1 Caldesmon Actin-binding Q28708 100009077 rabbit S529-p 448466 QSVDKVTsPTKV___ molecular association, regulation; protein conformation HSP27(INDUCES); TPM1(DISRUPTS) 16627824 19 19 0 -SEPTIN5 SEPT5 iso2 Cell cycle regulation; Cytoskeletal; Hydrolase; Vesicle Q99719-2 5413 22q11.21 human S17-p 475075 RLVEQLLsPRTQAQR molecular association, regulation STX1A(DISRUPTS) 17224448 2 7 2 -MAP4 MAP4 Cytoskeletal; Motility/polarity/chemotaxis ACK86564 100302596 cat S924-p 1210622 NVRSKVGsTENIKHQ Tubulin-binding cytoskeletal reorganization 20436166 4 53 41 -LRATD1 LRATD1 Unknown function Q96KN4 151354 2p24.3 human S38-p 469624 VGVAYFFsDDEEDLD cell motility, altered; cytoskeletal reorganization 16820875 2 0 0 -Glp1r GLP1R GPCR, family 2; Membrane protein, integral; Membrane protein, multi-pass; Receptor, GPCR P32301 25051 20p12 rat S441-p 451368 KPLKCPTsSVSSGAT receptor desensitization, altered 8702711 1 0 0 -NR1I2 PXR DNA-binding; Nuclear receptor O75469 8856 3q13.33 human T133-p 30259803 KRKKSERtGTQPLGV molecular association, regulation DNA(DISRUPTS) 24184507 1 2 0 -DENND3 DENND3 GEF; GEF, Rab A2RUS2 22898 8q24.3 human S472-p 7997148 THRRMVVsMPNLQDI molecular association, regulation 14-3-3 beta(INDUCES) 25925668 2 6 11 enhances its GEF activity toward Rab12 -PIP4K2C PIP4K2C Carbohydrate Metabolism - inositol phosphate; EC 2.7.1.149; Endoplasmic reticulum; Kinase, lipid; Motility/polarity/chemotaxis Q8TBX8 79837 12q13.3 human S324-p 34431501 GPPALVGsYGTSPEG PIP5K intracellular localization; phosphorylation cell growth, inhibited; signaling pathway regulation 25372051 1 1 0 inhibits expression of phosphorylated p70S6K and S6, inhibits mTORC1 signaling, regulates cell size -DTNBP1 DTNBP1 Vesicle Q96EV8 84062 6p22.3 human S297-p 9320776 ELRAKPPsSSSTCTD Dysbindin protein degradation; ubiquitination cell growth, inhibited; transcription, inhibited 30062698 1 3 2 phosphorylation inhibits cofilin transcription and does not reduce surface NR2A levels -PGR PR DNA-binding; Nuclear receptor; Transcription factor P06401 5241 11q22.1 human S294-p 447987 APMAPGRsPLATTVM Prog_receptor sumoylation; protein degradation; ubiquitination; intracellular localization carcinogenesis, altered; transcription, induced; cell adhesion, altered; cell growth, altered 10655479; 12554776; 17173941; 17717077; 19706513; 26577046; 27852068; 28412963 21 3 0 -CD19 CD19 Cell surface; Membrane protein, integral P15391 930 16p11.2 human Y409-p 447935 EEEEGEGyEEPDSEE activity, induced; molecular association, regulation; phosphorylation PLCG2(INDUCES); VAV1(INDUCES) 10706702 2 0 0 ERK2 phosphorylation; Ca(2+) influx -Trpv5 TRPV5 Channel, cation; Membrane protein, integral; Membrane protein, multi-pass; Motility/polarity/chemotaxis Q9XSM3 rabbit S299-p 470108 FLELVVSsKKREARQ activity, induced; intracellular localization 18305097; 19157541 3 0 0 CaR-dependent channel activation; inhibits caveolar endocytosis of TRPV5 -SLC26A4 SLC26A4 Membrane protein, integral; Membrane protein, multi-pass; Transporter; Transporter, SLC family O43511 5172 7q22.3 human T717-p 22561300 DDNIRKDtFFLTVHD STAS intracellular localization 22109890 1 0 0 -EGFR EGFR EC 2.7.10.1; KINASE; Kinase, protein; Membrane protein, integral; Oncoprotein; Protein kinase, TK; Protein kinase, tyrosine (receptor) P00533 1956 7p11.2 human Y1172-p 448059 ISLDNPDyQQDFFPK protein degradation; molecular association, regulation; receptor internalization, altered; phosphorylation; enzymatic activity, induced carcinogenesis, induced; cell motility, induced; signaling pathway regulation; cell growth, altered RASA1(INDUCES); GRB2(INDUCES); VAV2(INDUCES); SHP-1(INDUCES); DOK2(INDUCES); DOK1(INDUCES); EGFR(INDUCES); SHC1(INDUCES) 10508618; 12454019; 12842895; 1314835; 15476828; 16729043; 2022651; 2022652; 24430869; 26290602; 28102297; 3263271; 34367939; 7506413; 8408058; 9733788 44 60 967 triggers AKT, ERK phosphorylation and thus induces PI3K-AKT and MAPK-ERK signaling -USP8 USP8 DEUBIQUITINASE; EC 3.4.19.12; Protease; Ubiquitin conjugating system; Ubiquitin-specific protease P40818 9101 15q21.2 human S718-p 454338 SKLKRSYsSPDITQA molecular association, regulation; enzymatic activity, inhibited cell cycle regulation 14-3-3 beta(INDUCES); 14-3-3 sigma(INDUCES); 14-3-3 epsilon(INDUCES) 17720156; 26214742; 29880877 4 71 26 USP8 is activated in M phase and has less 14-3-3s associated; stabilization of RTKs -DLG4 PSD-95 Adaptor/scaffold P78352 1742 17p13.1 human S73-p 471390 ITLERGNsGLGFSIA PDZ molecular association, regulation NMDAR1(DISRUPTS) 25393018 6 4 0 in mature synapses; CaMKII was unable to trigger the complex separation in the presence of a calpain inhibitor. -FANCE FANCE DNA repair, damage Q9HB96 2178 6p21.31 human S374-p 476782 LFLGRILsLTSSASR FA_FANCE protein degradation; molecular association, regulation; intracellular localization FANCD2(INDUCES) 17296736 1 0 2 required for mitomycin C resistance -MYO6 MYO6 Actin-binding; Motility/polarity/chemotaxis; Motor Q9UM54 4646 6q14.1 human T405-p 449089 TAGGTKGtVIKVPLK Myosin_head intracellular localization 28348208 4 14 1 recruited to Salmonella-induced membrane ruffles -NFAT5 NFAT5 Transcription factor O94916 10725 16q22.1 human T135-p 469161 TVQQHPStPKRHTVL intracellular localization transcription, induced 21209322 1 5 9 -Kdr VEGFR2 EC 2.7.10.1; KINASE; Kinase, protein; Membrane protein, integral; Protein kinase, TK; Protein kinase, tyrosine (receptor) P35918 16542 5 C3.3|5 40.23 cM mouse S1188-p 18755300 TLSMEEDsGLSLPTS activity, induced; protein degradation; molecular association, regulation; ubiquitination BTRC(INDUCES) 21402774 1 0 0 -SLC25A5 SLC25A5 Membrane protein, integral; Membrane protein, multi-pass; Mitochondrial; Transporter; Transporter, SLC family P05141 292 Xq24 human T107-p 1876923700 LGGVDKRtQFWLYFA protein stabilization; acetylation apoptosis, inhibited 32194820 1 1 0 reciprocal regulation of T107, K105 -RAD51 RAD51 DNA repair, damage; Mitochondrial Q06609 5888 15q15.1 human K70-sm 1879760605 IKGISEAkADKILAE molecular association, regulation DNA repair, induced BRCA2(INDUCES) 35061896 2 0 0 RAD51 SUMOylation is required for HR-mediated DSB repair, GFP-TOPORS-WT restored the interaction between RAD51 and BRCA2, but the T515A mutant restored to a lesser degree -Cebpb C/EBP-beta DNA-binding; Motility/polarity/chemotaxis; Transcription factor P21272 24253 3q42 rat S240-p 452156 NNIAVRKsRDKAKMR bZIP_2 molecular association, regulation transcription, altered DNA(DISRUPTS) 8200992 3 0 0 -RELA NFkB-p65 DNA-binding; Nuclear receptor co-regulator; Transcription factor Q04206 5970 11q13.1 human K122-ac 458970 NLGIQCVkKRDLEQA RHD_DNA_bind activity, induced; molecular association, regulation; intracellular localization transcription, inhibited DNA(DISRUPTS) 12419806; 23087373; 23740527 6 2 24 inhibits inflammatory gene expression; induces beta-amyloid cytokine production, neurotoxicity, and neuronal cell death (inhibited by compound 11) -VCP VCP Chaperone; DNA repair, damage; EC 3.6.4.6; Endoplasmic reticulum; Hydrolase P55072 7415 9p13.3 human S784-p 456210 NQGGAGPsQGSGGGT protein degradation; molecular association, regulation; ubiquitination; intracellular localization; phosphorylation DNA repair, induced; carcinogenesis, inhibited; signaling pathway regulation NPL4(DISRUPTS); UFD1L(DISRUPTS) DNA(DISRUPTS) 16140914; 32521270; 34680224 3 4 33 -ELAVL1 HuR RNA-binding Q15717 1994 19p13.2 human S88-p 474552 LNGLRLQsKTIKVSY RRM_1 protein degradation; molecular association, regulation RNA splicing, induced; RNA stability, altered RNA(INDUCES); RNA(DISRUPTS) 17317627; 24865968; 32929216 4 0 0 -SLX4 SLX4 DNA repair, damage; Deoxyribonuclease Q8IY92 84464 16p13.3 human T1561-p 1880104208 LPPKVPItPMPQYSI molecular association, regulation; protein conformation MUS81(INDUCES) 36288699 1 1 0 -CSNK2B CK2B KINASE; Protein kinase, regulatory subunit P67870 1460 6p21.33 human S2-p 447646 ______MsSSEEVSW protein stabilization; enzymatic activity, induced CK2B(INDUCES) 12032843; 8269941 3 12 0 -NFE2L2 NRF2 DNA-binding; Transcription factor Q16236 4780 2q31.2 human S40-p 450082 SREVFDFsQRRKEYE activity, induced; protein stabilization; molecular association, regulation; intracellular localization carcinogenesis, induced; carcinogenesis, inhibited; apoptosis, inhibited; cell motility, inhibited; autophagy, inhibited; transcription, induced HMOX1(DISRUPTS); KEAP1(DISRUPTS); LANA(INDUCES); SIAH2(INDUCES) DNA(INDUCES) 12700136; 23645672; 25107906; 25236495; 25340789; 25505069; 26845617; 27517753; 33403569; 36240204; 36458309 33 0 0 -Tdg TDG DNA repair, damage; EC 3.2.2.29; Hydrolase; Nuclear receptor co-regulator P56581 21665 10 C1|10 39.72 cM mouse S96-p 11509301 KPATSKKsGKSTKSK molecular association, regulation; acetylation DNA repair, induced DNA(INDUCES) 19966277 1 0 1 inhibits acetylation at other sites -RPL23A RPL23A Ribosomal; Translation P62750 6147 17q11.2 human K123-ub 22251147 LYDIDVAkVNTLIRP Ribosomal_L23 protein degradation; ubiquitination transcription, altered 35637966 1 4 0 HERC3 could control protein expression and ubiquitination of c-Myc/p21 via RPL23A -Nphs1 NPHS1 Cell adhesion; Immunoglobulin superfamily; Membrane protein, integral Q9R044 64563 1q21 rat Y1127-p 6377602 EDRIRNEyEESQWTG molecular association, regulation; phosphorylation SHP-1(INDUCES) 25404734 2 0 0 -KCNA2 Kv1.2 Channel, potassium; Membrane protein, integral; Membrane protein, multi-pass P16389 3737 1p13.3 human Y417-p 455553 VSNFNYFyHRETEGE Ion_trans molecular association, regulation Cortactin(DISRUPTS) 12151401 1 0 0 -HCLS1 HS1 Adaptor/scaffold; Motility/polarity/chemotaxis P14317 3059 3q13.33 human Y397-p 451636 EDEPEGDyEEVLEPE activity, induced; molecular association, regulation; intracellular localization apoptosis, altered; cell motility, induced; cell adhesion, altered; cytoskeletal reorganization; transcription, altered ARPC2(INDUCES); VAV1(INDUCES) 16782030; 18587398; 22679023; 25723543; 9104825 9 1 7 -BORA BORA Activator Q6PGQ7 79866 13q21.33 human S137-p 9320596 CTNINSDsPVGKKLT BORA_N molecular association, regulation cell cycle regulation PLK1(INDUCES) 27068477 1 6 1 -DEPTOR DEPTOR Apoptosis Q8TB45 64798 8q24.12 human S299-p 4723878 SSPTLSSsPPVLCNP protein degradation; molecular association, regulation carcinogenesis, induced; apoptosis, inhibited; signaling pathway regulation BTRC(INDUCES); mTOR(DISRUPTS) 19446321; 22017875; 22017877 3 6 1 PI3K-Akt signaling -EEF1A1 EEF1A1 Nucleolus; Translation; Translation elongation P68104 1915 6q13 human K55-m2 3898705 EMGKGSFkYAWVLDK GTP_EFTU molecular association, regulation; enzymatic activity, induced carcinogenesis, induced; cell motility, induced; cell growth, induced; apoptosis, inhibited; translation, induced L3MBTL iso4(INDUCES) 23583077; 30612740; 32347192 4 7 11 -ERBB4 HER4 EC 2.7.10.1; KINASE; Kinase, protein; Membrane protein, integral; Protein kinase, TK; Protein kinase, tyrosine (receptor) Q15303 2066 2q34 human T699-p 9430151 TELVEPLtPSGTAPN enzymatic activity, inhibited; phosphorylation signaling pathway regulation 31053301 1 3 8 downregulates phosphorylation of Y1284; MEK-ERK pathway-dependent feedback inhibition of HER4 activation -Becn1 beclin 1 Adaptor/scaffold; Autophagy; Membrane protein, peripheral O88597 56208 11|11 D mouse K115-ub 14991107 ENLSRRLkVTGDLFD BH3 cell differentiation, induced 31074883 2 0 0 osteoclast differentiation, chondrocyte differentiation is impaired in Beclin1 cKO mice -Becn1 beclin 1 Adaptor/scaffold; Autophagy; Membrane protein, peripheral O88597 56208 11|11 D mouse S94-p 472002 MSTESANsFTLIGEA autophagy, induced 34287052 4 2 1 -Mapt Tau ACETYLTRANSFERASE; Acetyltransferase; Cytoskeletal P10637 17762 11 67.79 cM|11 E1 mouse S648-p 449104 RVQSKIGsLDNITHV Tubulin-binding protein degradation 17573348 35 24 0 LKB1-MARK signaling causes proteasome-mediated degradation of Tau. -GRIK2 GluR6 Channel, calcium; Channel, ligand-gated; Membrane protein, integral; Membrane protein, multi-pass Q13002 2898 6q16.3 human K886-sm 12004405 PQAPVIVkTEEVINM sumoylation; receptor internalization, induced; intracellular localization; phosphorylation; palmitoylation neural plasticity; endocytosis, altered 22522402; 37868810 4 0 0 palmitoylation maintains surface expression and regulates agonist -induced internalisation; long-term depression (LTD) of KAR receptor mediated synaptic transmission -MLH1 MLH1 Cell cycle regulation; DNA repair, damage; Tumor suppressor P40692 4292 3p22.2 human S477-p 480003 RKRHREDsDVEMVED protein stabilization; intracellular localization; protein conformation carcinogenesis, induced; DNA repair, inhibited 30136313; 35326704 3 22 191 -Oprd1 DOR-1 GPCR, family 1; Membrane protein, integral; Membrane protein, multi-pass; Receptor, GPCR P32300 18386 4 D2.3|4 64.78 cM mouse T353-p 3146600 RRPRQATtRERVTAC protein degradation; intracellular localization; receptor internalization, altered 10701775; 21220103 2 0 0 -MAPK14 P38A EC 2.7.11.24; KINASE; Kinase, protein; Protein kinase, CMGC; Protein kinase, Ser/Thr (non-receptor) Q16539 1432 6p21.31 human Y182-p 447971 TDDEMTGyVATRWYR Pkinase activity, induced; phosphorylation; enzymatic activity, induced cell cycle regulation; carcinogenesis, induced; apoptosis, altered; apoptosis, induced; signaling pathway regulation; cell growth, induced; cell motility, altered; transcription, inhibited; carcinogenesis, inhibited; cell growth, inhibited; transcription, induced; autophagy, induced; cell differentiation, induced; cytoskeletal reorganization; cell adhesion, altered; autophagy, inhibited P38A(INDUCES) 10201954; 10867021; 11994493; 15944157; 16966330; 17126298; 17438131; 17548358; 18047584; 18560558; 19336399; 21177868; 21878628; 22039048; 33676898; 33685990; 34048499; 34148056; 34209868; 34995286; 35189144; 35569509; 35849202; 36219392; 36289618; 8622669 410 123 3683 autoamplifcation of NFAT-c1, which promotes osteoclast differentiation, suppressed by MLN4924 -Npy1r NPY1R GPCR, family 1; Membrane protein, integral; Membrane protein, multi-pass; Receptor, GPCR P21555 29358 16p14 rat S367-p 2815301 KTSLKQAsPVAFKKI receptor internalization, altered 15576634 1 7 0 may be an artifact of the truncation mutants -Rps6 S6 Translation P62754 20104 4|4 C4 mouse S236-p 448093 AKRRRLSsLRASTSK carcinogenesis, induced; carcinogenesis, inhibited; signaling pathway regulation; neural plasticity; cell growth, induced; autophagy, inhibited; translation, induced; transcription, inhibited 18851840; 23361300; 33826903; 34342159; 34426542; 34695513; 35428325; 37068088 239 72 1124 Promotes axonal regeneration in the nervous systems -Eif4ebp1 4E-BP1 Translation; Translation initiation Q62622 116636 16q12.3 rat T69-p 447528 RNSPVAKtPPKDLPT eIF_4EBP molecular association, regulation; phosphorylation translation, altered EIF4E(INDUCES); EIF4E(DISRUPTS) 10779345; 20736160; 9806882 55 57 9 -NEK9 NEK9 Autophagy; EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, Other; Protein kinase, Ser/Thr (non-receptor) Q8TD19 91754 14q24.3 human S869-p 7322159 KPQVEASsPRLNPAV molecular association, regulation; phosphorylation; enzymatic activity, induced PLK1(INDUCES) 21642957 1 15 2 phosphorylation of the priming site induces phosphorylation at T210 -CHUK IKKA EC 2.7.11.10; KINASE; Kinase, protein; Protein kinase, Other; Protein kinase, Ser/Thr (non-receptor) O15111 1147 10q24.31 human S180-p 447779 DQGSLCTsFVGTLQY Pkinase activity, induced; enzymatic activity, induced chromatin organization, altered; cell motility, altered; transcription, induced 17880897; 18950704; 19073147; 33883226 44 0 0 -P2RX3 P2X3 Channel, ligand-gated; Membrane protein, integral; Membrane protein, multi-pass P56373 5024 11q12.1 human S178-p 458896 FTIFIKNsIRFPLFN P2X_receptor receptor desensitization, altered 16226373 1 0 0 -PHF5A PHF5A RNA splicing; RNA-binding Q7RTV0 84844 22q13.2 human K29-ac 1879864500 LCEKCDGkCVICDSY molecular association, regulation carcinogenesis, induced; RNA splicing, induced; cell growth, induced; transcription, induced; signaling pathway regulation SF3B1(INDUCES) 31054974 1 1 0 fraction of 11 genes were commonly changed in differentially expressed genes, upregulation of KDM3A expression and activates the Wnt signaling pathway in colorectal cancer -Lpp LPP Adaptor/scaffold; Cytoskeletal; Motility/polarity/chemotaxis Q8BFW7 210126 16|16 B1 mouse Y302-p 448949 GRYYEPYyAAGPSYG cell cycle regulation; cell motility, altered 18515860 2 25 526 -WNK4 WNK4 EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, Other; Protein kinase, Ser/Thr (non-receptor) Q96J92 65266 17q21.2 human S1217-p 5879855 PGIMRRNsLSGSSTG activity, induced 23054253; 23673010 5 11 9 BK channel activity induced; regulates NKCC2 activity -DNMT3A DNMT3A Amino Acid Metabolism - cysteine and methionine; EC 2.1.1.37; METHYLTRANSFERASE; Methyltransferase; Methyltransferase, DNA Q9Y6K1 1788 2p23.3 human S393-p 17548182 VCHDSDEsDTAKAVE methylation; intracellular localization; enzymatic activity, inhibited 25066127 1 4 0 decreases methylation of CpG -DRD2 DRD2 GPCR, family 1; Membrane protein, integral; Membrane protein, multi-pass; Receptor, GPCR P14416 1813 11q23.2 human S228-p 487432 KRVNTKRsSRAFRAH 7tm_1 receptor desensitization, induced 17869243 2 0 0 -GOT2 GOT2 Amino Acid Metabolism - alanine, aspartate and glutamate; Amino Acid Metabolism - arginine and proline; Amino Acid Metabolism - cysteine and methionine; Amino Acid Metabolism - phenylalanine; Amino Acid Metabolism - phenylalanine, tyrosine and tryptophan biosynthesis; Amino Acid Metabolism - tyrosine; EC 2.6.1.1; EC 2.6.1.7; Mitochondrial; Transferase P00505 2806 16q21 human K185-ac 466484 GYRYYDPkTCGFDFT Aminotran_1_2 molecular association, regulation; phosphorylation carcinogenesis, induced; cell growth, induced; apoptosis, inhibited MDH2(INDUCES) 25755250 1 4 2 induces H3 phosphorylation -SPOP SPOP UBIQUITIN LIGASE; Ubiquitin ligase O43791 8405 17q21.33 human S119-p 1874115101 EETKAMEsQRAYRFV MATH molecular association, regulation; phosphorylation DNA repair, induced; carcinogenesis, inhibited; cell growth, inhibited; signaling pathway regulation HIPK2(INDUCES) 34133717 1 0 0 induces HIPK2-HP1 signaling pathway by inducing HP1 phosphorylation -RPS6KA4 MSK2 EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, AGC; Protein kinase, Ser/Thr (non-receptor) O75676 8986 11q13.1 human S324-p 11489900 PFRPQIRsELDVGNF Pkinase_C phosphorylation; enzymatic activity, induced 19933278 1 0 0 stimulates phosphorylation of S196 -IRF3 IRF3 DNA-binding; Transcription factor Q14653 3661 19q13.33 human S405-p 449032 SHPLSLTsDQYKAYL activity, induced; protein degradation; molecular association, regulation; intracellular localization; protein conformation; phosphorylation autophagy, induced; transcription, induced; transcription, altered CALCOCO2(INDUCES); CBP(INDUCES) 17526488; 18272581; 19153595; 25070846; 27992402; 37330913; 9566918 8 1 0 GPR108 and Smurf1 mediated degradation requires NDP52; NDP52-dependent autophagic degradation of phosphorylated IRF3; GPR108 interacts with Smurf1, followed by the recruitment of IRF3 during viral infection -POLI POLI DNA repair, damage; EC 2.7.7.7; Transferase Q9UNA4 11201 18q21.2 human K296-ub 22249756 FSPKILEkELGISVA protein degradation 26370087 1 3 0 -PKN1 PKN1 EC 2.7.11.13; KINASE; Kinase, protein; Protein kinase, AGC; Protein kinase, Ser/Thr (non-receptor) Q16512 5585 19p13.12 human T774-p 447835 GYGDRTStFCGTPEF Pkinase molecular association, regulation; enzymatic activity, induced cytoskeletal reorganization HADHB(INDUCES); HADHA(INDUCES); PDK1(INDUCES) 10753910; 10792047; 26296974 7 5 319 -VASP VASP Cytoskeletal; Motility/polarity/chemotaxis P50552 7408 19q13.32 human S322-p 469024 TTLPRMKsSSSVTTS intracellular localization cytoskeletal reorganization; cell motility, inhibited 23846685; 26336132 3 15 45 Increases Filopodia formation; patients with high expression of PKD2 showed an increase in relapse-freee survival. -Ceacam20 CEACAM20 Immunoglobulin superfamily; Membrane protein, integral Q9D2Z1 71601 7|7 A3 mouse Y570-p 41604101 LNSNHSLyCKITPSA transcription, induced 26195794 1 1 0 increase in IL-8 production -KCNK2 TREK-1 iso2 Channel, potassium; Membrane protein, integral; Membrane protein, multi-pass O95069-2 3776 1q41 human S300-p 456160 GDWLRVIsKKTKEEV activity, inhibited neural plasticity 33006141 4 0 0 -GSK3B GSK3B EC 2.7.11.1; EC 2.7.11.26; KINASE; Kinase, protein; Protein kinase, CMGC; Protein kinase, Ser/Thr (non-receptor) P49841 2932 3q13.33 human Y56-p 1867735501 DRPQEVSyTDTKVIG Pkinase activity, induced; ubiquitination carcinogenesis, inhibited; cell growth, inhibited; transcription, inhibited 30711629 1 1 0 decreases transcription of PDL1; inhibits TRAF6-mediated GSK3B ubiquitination -TWIST1 TWIST1 Cell development/differentiation; DNA-binding; Inhibitor; Transcription regulation Q15672 7291 7p21.1 human K73-ub 1883509402 PGSPAQGkRGKKSAG protein degradation cell growth, inhibited; cell motility, inhibited 36115849 1 0 0 -BACE1 BACE EC 3.4.23.46; Membrane protein, integral; Protease P56817 23621 11q23.3 human K307-ac 478255 KVFEAAVkSIKAASS Asp protein stabilization; intracellular localization 17425515 1 1 0 regulates translocation through secretory pathway -MCM4 MCM4 DNA replication; EC 3.6.4.12 P33991 4173 8q11.21 human S54-p 448667 ELQPMPTsPGVDLQS activity, inhibited 12714602 3 5 5 -PTPN5 STEP EC 3.1.3.48; Membrane protein, multi-pass; Motility/polarity/chemotaxis; PHOSPHATASE; Protein phosphatase, tyrosine (non-receptor) P54829 84867 11p15.1 human S184-p 51170600 PPEDRRQsVSRQPSF molecular association, regulation; enzymatic activity, inhibited ERK1(DISRUPTS); ERK2(DISRUPTS) 26574547 2 0 0 -FLII FLI Actin-binding; Nuclear receptor co-regulator Q13045 2314 17p11.2 human S64-p 1163832400 KLEHLSVsHNNLTTL LRR_8 molecular association, regulation autophagy, induced KHDRBS1(DISRUPTS) 29898994 1 0 0 -TSC1 TSC1 Motility/polarity/chemotaxis; Tumor suppressor Q92574 7248 9q34.13 human T310-p 478102 SYGCATStPYSTSRL Hamartin molecular association, regulation PLK1(INDUCES) 16339216 1 0 0 -MAP3K3 MEKK3 EC 2.7.11.25; KINASE; Kinase, protein; Protein kinase, STE; Protein kinase, Ser/Thr (non-receptor) Q99759 4215 17q23.3 human S520-p 12607406 RLQTICMsGTGMRSV Pkinase enzymatic activity, induced 20068038 2 1 0 essential for MEKK3-mediated IKK-beta/NFkB activation -Slc10a2 ASBT Membrane protein, integral; Membrane protein, multi-pass; Transporter Q62633 29500 16q12.5 rat S335-p 453445 NDMDPMPsFQETNKG protein degradation 15304498 2 1 0 -Cdk1 CDK1 Cell cycle regulation; EC 2.7.11.22; EC 2.7.11.23; KINASE; Kinase, protein; Motility/polarity/chemotaxis; Protein kinase, CMGC; Protein kinase, Ser/Thr (non-receptor) P11440 12534 10 B5.3|10 36.07 cM mouse T14-p 447608 IEKIGEGtYGVVYKG Pkinase enzymatic activity, inhibited cell cycle regulation 1655417 34 117 1764 -SPAG9 JIP4 Adaptor/scaffold; Cancer Testis Antigen (CTA) O60271 9043 17q21.33 human S730-p 453192 GSKQRSAsQSSLDKL enzymatic activity, inhibited 34319782 1 53 3 inhibits IAV polymerase activity thus producing an antiviral response -Sgk1 SGK1 EC 2.7.11.1; KINASE; Kinase, protein; Motility/polarity/chemotaxis; Protein kinase, AGC; Protein kinase, Ser/Thr (non-receptor) Q06226 29517 1p12 rat S421-p 448429 AEAFLGFsYAPPMDS Pkinase_C enzymatic activity, induced transcription, induced 10357815; 18088355 30 0 0 involved in spatial memory formation by increasing expression of zif268 in hippocampus, through phosphorylation of SRF S99 and CREB S133 -KIF13B KIF13B Microtubule-binding; Motor Q9NQT8 23303 8p12 human S1381-p 4691956 KLSRRSIsSPNVNRL molecular association, regulation; intracellular localization; protein conformation cell growth, inhibited; cytoskeletal reorganization 14-3-3 beta(INDUCES) 20194617 1 46 14 regulates intramolecular interaction -Ccdc88a girdin Actin-binding Q5SNZ0 108686 11|11 A3.3 mouse S1417-p 456477 INRERQKsLTLTPTR neural plasticity; cell motility, induced; cell growth, induced 25378165; 25732845; 26393439 9 18 1 enhances proliferative and migratory responses in fibroblasts, facilitates tumor growth; regulates cardiac repair processes after myocardial infarction and prevents mortality due to cardiac rupture -DCTN1 dynactin 1 Microtubule-binding; Motility/polarity/chemotaxis; Motor Q14203 1639 2p13.1 human S179-p 15512801 SASAGELsSSEPSTP protein stabilization; molecular association, regulation; intracellular localization cell cycle regulation; carcinogenesis, induced; apoptosis, inhibited; transcription, altered 20679239; 23661607 2 0 0 induce AR stabilization and nuclear translocation/accumulation; inhibits dynactin 1 interaction with microtubules -TRIM28 TIF1B EC 6.3.2.-; KINASE; Kinase, protein; Ligase; Nuclear receptor co-regulator; Protein kinase, atypical; SUMO LIGASE; SUMO ligase; Transcription, coactivator/corepressor; UBIQUITIN LIGASE; Ubiquitin conjugating system; Ubiquitin ligase Q13263 10155 19q13.43 human K804-sm 2798311 NEAFGDTkFSAVLVE molecular association, regulation; acetylation; methylation cell growth, induced; transcription, inhibited CHD-3(INDUCES) 17079232; 17942393; 21642969; 31391303 5 4 0 loss of TF1B sumoylation induces dsRNA-activated IFN-mediated defenses that rely on RIG-I, MAVS, TBK1, and JAK1 transcription, SUMOylated TIF1B Is required to support efficient virus replication -KHDC3L KHDC3L Cell cycle regulation Q587J8 154288 6q13 human T145-p 1673970100 IEVREAGtQRSVEVR activity, induced; molecular association, regulation DNA repair, induced; cell growth, induced PARP1(INDUCES) 31609975 1 0 0 -CYLD CYLD DEUBIQUITINASE; EC 3.4.19.12; Protease; Tumor suppressor; Ubiquitin conjugating system; Ubiquitin-specific protease Q9NQC7 1540 16q12.1 human S432-p 12173909 KMPNTNGsIGHSPLS CYLD_phos_site ubiquitination 15870263 1 0 0 induces ubiquitination of TRAF2 -POLI POLI DNA repair, damage; EC 2.7.7.7; Transferase Q9UNA4 11201 18q21.2 human K308-ub 21181890 SVAQRIQkLSFGEDN protein degradation 26370087 1 3 0 -Ptpn11 SHP-2 EC 3.1.3.48; Motility/polarity/chemotaxis; PHOSPHATASE; Protein phosphatase, tyrosine (non-receptor) P35235 19247 5|5 F mouse Y279-p 474206 ENKNKNRyKNILPFD Y_phosphatase phosphorylation; enzymatic activity, induced cell cycle regulation 18827006 1 6 66 -Krt17 K17 Cytoskeletal Q9QWL7 16667 11 D|11 63.44 cM mouse T9-p 464290 TTTIRQFtSSSSIKG molecular association, regulation cell cycle regulation 14-3-3 sigma(NOT_REPORTED) 16710422 1 0 0 Mutation of T8 and S43 (to alanine) causes reduced phosphorylation of Akt S473 and p70S6K T389. -Map2 MAP2 iso3 Cytoskeletal; Motility/polarity/chemotaxis P15146-3 25595 9q32 rat K396-ac 62495508 VPGGGNVkIDSQKLN cytoskeletal reorganization 28002468 1 1 0 -RAB10 RAB10 G protein; G protein, monomeric; G protein, monomeric, Rab P61026 10890 2p23.3 human T73-p 471953 AGQERFHtITTSYYR Ras autophagy, inhibited 34515301 18 13 13 -HSP90AA1 HSP90A Chaperone; Heat shock protein P07900 3320 14q32.31 human T115-p 13256102 GTIAKSGtKAFMEAL HATPase_c molecular association, regulation; enzymatic activity, inhibited; protein conformation cell cycle regulation CDC37(DISRUPTS); TTK(INDUCES); PKCG(DISRUPTS); AHSA1(INDUCES); HER2(INDUCES) 24117238; 26804907 2 0 0 -BBC3 PUMA Apoptosis; Mitochondrial Q9BXH1 27113 19q13.32 human S106-p 18610002 LAEQHLEsPVPSAPG PUMA molecular association, regulation; intracellular localization MPC1(INDUCES) 30712844 2 0 0 PUMA interacts with MPC and distrupts the oligomerization of MPC1 and MPC2 -MARK2 MARK2 EC 2.7.11.1; EC 2.7.11.26; KINASE; Kinase, protein; Protein kinase, CAMK; Protein kinase, Ser/Thr (non-receptor) Q7KZI7 2011 11q13.1 human T596-p 453427 RGVSSRStFHAGQLR molecular association, regulation; intracellular localization; enzymatic activity, inhibited; phosphorylation; enzymatic activity, induced translation, induced; signaling pathway regulation 14-3-3 beta(INDUCES) 15084291; 15324659; 19011111; 33705388 5 19 1 induces elF2 phosphorylation and hence the PKCd-MARK2-eIF2a signaling pathway -DUSP6 DUSP6 EC 3.1.3.16; EC 3.1.3.48; Motility/polarity/chemotaxis; PHOSPHATASE; Protein phosphatase, dual-specificity Q16828 1848 12q21.33 human S174-p 5938001 LGGLRISsDSSSDIE protein degradation 19106095 1 0 0 -NPM1 NPM1 Nucleolus; Oncoprotein; RNA-binding; Translation P06748 4869 5q35.1 human K212-ac 466414 QKSNQNGkDSKPSST molecular association, regulation; intracellular localization transcription, altered H3(INDUCES) 19581289 1 5 31 K212/215/229/230/257/267/292R mutant -HEXIM1 HEXIM1 Motility/polarity/chemotaxis; Transcription factor O94992 10614 17q21.31 human S158-p 25680402 KKHRRRPsKKKRHWK molecular association, regulation; activity, inhibited transcription, induced BCDIN3(DISRUPTS); CHD-4(DISRUPTS) RNA(DISRUPTS) 22821562; 31183407 2 0 0 promotes cystogenesis of kidney cells; inctivated ability to inhibit P-TEFb, increased levels of free P-TEFb in cells -RDX Radixin Cytoskeletal; Motility/polarity/chemotaxis P35241 5962 11q22.3 human T564-p 448374 AGRDKYKtLRQIRQG ERM_C intracellular localization; activity, inhibited; phosphorylation cytoskeletal reorganization 25799996; 33836044 21 7 16 pERM in the retraction fibers; inhibits Rho activity, regulates MLC2 phosphorylation -SMURF2 SMURF2 EC 6.3.2.-; EC 6.3.2.19; Ligase; UBIQUITIN LIGASE; Ubiquitin conjugating system; Ubiquitin ligase Q9HAU4 64750 17q23.3-q24.1 human K369-sm 52415800 CLTVPRYkRDLVQKL signaling pathway regulation 26679521 2 0 0 regulation of TGF-beta induced epithelial-mesenchymal transition -DDB2 DDB2 DNA repair, damage Q92466 1643 11p11.2 human K35-ub 1876931106 LELEPEAkKLCAKGS DNA repair, induced 32789493 1 1 0 SIRT6 as a critical factor in the regulation of the process of UV-induced DNA damage repair -HNF4A HNF4 alpha DNA-binding; Nuclear receptor; Transcription factor P41235 3172 20q13.12 human Y288-p 22996303 IDDNEYAyLKAIIFF Hormone_recep protein degradation; intracellular localization; phosphorylation transcription, inhibited 22308320 1 1 0 reduced nuclear localization and protein stability; multistep phosphorylation by Src, phosphorylating Y23 first, which interacts with the Src SH2 domain, followed by phosphorylation of Y286, Y288 -CASR CaR GPCR, family 3; Membrane protein, integral; Membrane protein, multi-pass; Motility/polarity/chemotaxis; Receptor, GPCR P41180 846 3q13.33-q21.1 human S899-p 15507601 SNVSRKRsSSLGGST molecular association, regulation; intracellular localization 14-3-3 beta(INDUCES); 14-3-3 beta(DISRUPTS) 20798521; 26317416 2 0 1 -MYOD1 MyoD DNA-binding; RNA splicing; Transcription factor P15172 4654 11p15.1 human S201-p 40684505 SGDSDASsPRSNCSD Myf5 molecular association, regulation; activity, inhibited transcription, inhibited SUV39H1(INDUCES) DNA(INDUCES) 20026657 8 1 0 MyoD binding to SUV39H1 results in SUV39H1 binding to DNA. -Uso1 TAP Motility/polarity/chemotaxis; Vesicle P41542 56042 14p22 rat S940-p 450465 PVEEEDEsGDQEDDD Uso1_p115_C intracellular localization 14533739 3 69 42 phosphorylation of site increases association with Golgi membranes in vitro, but not in vivo -MYOD1 MyoD DNA-binding; RNA splicing; Transcription factor P15172 4654 11p15.1 human Y30-p 449872 FATTDDFyDDPCFDS Basic cell differentiation, inhibited; cell cycle regulation; DNA repair, induced; transcription, induced 28446595 3 0 0 30F mutant overides senescence-associated inhibition of the myogenic program -Atp6v1a ATP6V1A EC 3.6.3.14; Energy Metabolism - oxidative phosphorylation; Hydrolase P50516 11964 16|16 B4 mouse S175-p 14913505 LPPRNRGsVTYIAPP ATP-synt_ab_Xtn intracellular localization; enzymatic activity, induced cell motility, induced 20525692; 26911844 3 1 0 ATP6V1A subunit expression at the leading edge, extracellular acidification -DNAJC5 DNAJC5 Vesicle Q9H3Z4 80331 20q13.33 human S34-p 10407117 TSDDIKKsYRKLALK DnaJ molecular association, regulation apoptosis, inhibited HSP70(INDUCES) 29167402 1 1 1 maintain normal conformation of SNAP25, protect dopaminergic neurons -Pawr PAR-4 Apoptosis Q62627 64513 7q21 rat S223-p 476476 GRYKSTIsAPEEEIL ATG16 apoptosis, inhibited; transcription, induced 24457960 1 15 18 -KCNIP3 calsenilin Calcium-binding; Transcription factor Q9Y2W7 30818 2q11.1 human K90-sm 25336513 QAQTKFTkKELQSLY intracellular localization transcription, inhibited 21070824 1 0 0 -GRIA1 GluR1 Channel, calcium; Channel, ligand-gated; Membrane protein, integral; Membrane protein, multi-pass P42261 2890 5q33.2 human C829-pa 9486202 LVALIEFcYKSRSES molecular association, regulation; intracellular localization; phosphorylation EPB41L1(DISRUPTS) 19503082 1 0 0 depalmitoylation of C829 (aka C811) enhances GluR1 phosphorylation at S834 (aka S816) and S836 (aka S818); depalmitoylation of C829 (aka C811) enhances the interaction with EPB41L1 (4.1N) and receptor insertion into plasma membrane -Sv2a SV2A Membrane protein, integral; Membrane protein, multi-pass; Vesicle Q9JIS5 64051 3|3 F2.1 mouse S80-p 4779752 DEEEGGAsSDATEGH molecular association, regulation SYT1(INDUCES) 25673844 1 9 11 SV2A retrieval during SV endocytosis, Thr84 of SV2A is critical in promoting the interaction with synaptotagmin-1 -Cebpb C/EBP-beta DNA-binding; Motility/polarity/chemotaxis; Transcription factor P28033 12608 2 H3|2 87.58 cM mouse K39-ac 473550 DCLAYGAkAARAAPR cell differentiation, induced; transcription, induced 17110376; 18486321 4 0 0 -BCAR1 P130Cas Adaptor/scaffold; Motility/polarity/chemotaxis P56945 9564 16q23.1 human Y249-p 448721 APGPQDIyDVPPVRG carcinogenesis, induced; cell growth, induced; transcription, induced 26867768; 34192548 14 44 723 -CLASP2 CLASP2 Cytoskeletal; Motility/polarity/chemotaxis O75122 23122 3p22.3 human S507-p 481392 QGCSREAsPSRLSVA cytoskeletal reorganization 22467876 1 18 10 -PRDX1 PRDX1 EC 1.11.1.15; Nuclear receptor co-regulator; Oxidoreductase Q06830 5052 1p34.1 human T183-p 476233 GWKPGSDtIKPDVQK 1-cysPrx_C enzymatic activity, inhibited 23386615 1 5 0 -UBA52-RPS27A-UBB-UBC ubiquitin Ubiquitin-like modifier P62988 2p16 human K11-ub 486301 FVKTLTGkTITLEVE ubiquitin protein degradation; molecular association, regulation; ubiquitination autophagy, induced; transcription, induced; signaling pathway regulation LC3B(INDUCES); ubiquitin(INDUCES); Cezanne(INDUCES); PSMD5(INDUCES) 18613717; 31937588; 32076268; 33824312; 34017102; 36379251; 8576261 25 22 155 TRIM26 enhances TLRs-induced NF-kB and MAPK signaling.; polyubiquitylation at multiple sites including K120, and monoubiquitylation leads to activation of transcription, K11-linked and K11/K48-branched chains-active APC/C, accumulated at specific genes in mitotic hESCs co-occupied by WDR5 and TBP; BAP37 promotes ef?cient mitophagy -AMOT AMOT Q4VCS5 154796 Xq23 human T750-p 56589712 DMEGRIKtLHAQIIE Angiomotin_C molecular association, regulation; intracellular localization cell motility, induced YAP1(DISRUPTS) 27321186 1 0 0 induces YAP1 nuclear localization -GSTP1 GSTP1 EC 2.5.1.18; Other Amino Acids Metabolism - glutathione; Transferase; Xenobiotic Metabolism - drug metabolism - cytochrome P450; Xenobiotic Metabolism - metabolism by cytochrome P450 P09211 2950 11q13.2 human Y4-p 462289 ____MPPyTVVYFPV GST_N protein conformation; enzymatic activity, induced 19254954 2 1 6 -ADD1 ADD1 Cytoskeletal; Motility/polarity/chemotaxis P35611 118 4p16.3 human S481-p 451596 KEDGHRTsTSAVPNL intracellular localization 25978380 2 3 1 localized at cell-cell borders, Ca2+ depletion, reduced or complete absence of alpha-adducin and alpha-adducin (pSer481) at cell-cell-junctions -DDX5 DDX5 EC 3.6.4.13; Helicase; Nuclear receptor co-regulator; Nucleolus; RNA splicing; RNA-binding; Spliceosome P17844 1655 17q23.3 human R484-m2 27280649 DRGSGRSrGRGGMKD molecular association, regulation XRN2(INDUCES) 31267554 1 2 1 represses R-loops -Tsc2 TSC2 Cell cycle regulation; GAP; GAP, misc.; Nuclear receptor co-regulator; Tumor suppressor P49816 24855 10q12 rat T1203-p 19075303 EILVRRPtGNTSWLM signaling pathway regulation 21561859 1 0 0 activation of mTORC1 -BDKRB2 BKR2 GPCR, family 1; Membrane protein, integral; Membrane protein, multi-pass; Receptor, GPCR P30411 624 14q32.2 human Y332-p 451672 SCLNPLVyVIVGKRF 7tm_1; TM molecular association, regulation; receptor internalization, altered; intracellular localization 15161928 1 0 0 -ARHGEF2 ARHGEF2 GEF; GEF, Rac/Rho; Motility/polarity/chemotaxis Q92974 9181 1q22 human S960-p 467500 SRLSPPHsPRDFTRM molecular association, regulation; enzymatic activity, inhibited cell cycle regulation 14-3-3 zeta(INDUCES) 17488622 3 46 13 -MYBPC3 MYBPC3 Myosin-binding Q14896 4607 11p11.2 human S284-p 471080 AGGGRRIsDSHEDTG protein stabilization; intracellular localization cytoskeletal reorganization 20018870; 22281395 35 8 28 -SLFN12 SLFN12 Unknown function Q8IYM2 55106 17q12 human S573-p 1876351802 NDKKMFKsCRRLT__ enzymatic activity, inhibited RNA stability, induced 35104454 1 1 0 -HNRNPA0 hnRNP A0 RNA splicing; RNA-binding Q13151 10949 5q31.2 human S84-p 449874 VELKRAVsREDSARP molecular association, regulation; intracellular localization RNA(INDUCES) 26602816 2 9 2 association of p27Kip1 mRNA -LAT LAT iso2 Adaptor/scaffold; Membrane protein, integral O43561-2 27040 16p11.2 human Y226-p 448006 EEEGAPDyENLQELN LAT molecular association, regulation; phosphorylation cell differentiation, altered; signaling pathway regulation; transcription, altered GRB2(INDUCES); GADS(INDUCES); THEMIS(INDUCES); TSAd(INDUCES) 11395491; 12496416; 15029250; 23460737; 27896837; 30510001; 34161759 17 3 72 induces Erk and calcium signaling -MAPT Tau iso8 ACETYLTRANSFERASE; Acetyltransferase; Cytoskeletal P10636-8 4137 17q21.31 human S199-p 447927 GDRSGYSsPGSPGTP O-GlcNAc glycosylation; molecular association, regulation; intracellular localization; protein conformation; phosphorylation cytoskeletal reorganization WWOX(INDUCES); Fyn(DISRUPTS); Tau iso8(INDUCES); Tau(INDUCES) 15126504; 15190058; 15364924; 16115884; 16923168; 18725412; 19451179; 20550628; 24312574; 35857446 91 33 33 -TLR4 TLR4 Membrane protein, integral; Receptor, misc. O00206 7099 9q33.1 human Y680-p 478361 IYDAFVIySSQDEDW TIR molecular association, regulation; phosphorylation transcription, induced IRAK1(DISRUPTS); MYD88(DISRUPTS) 17392283 1 0 0 IRAK1 short form -Pkm PKM Carbohydrate Metabolism - glycolysis and gluconeogenesis; Carbohydrate Metabolism - pyruvate; EC 2.7.1.40; KINASE; Kinase, other; Mitochondrial; Nucleotide Metabolism - purine P52480 18746 9 B|9 32.03 cM mouse Y105-p 450528 FASDPILyRPVAVAL PK molecular association, regulation; intracellular localization; enzymatic activity, inhibited; phosphorylation carcinogenesis, induced; carcinogenesis, altered; cell differentiation, induced; apoptosis, induced; transcription, induced; signaling pathway regulation; cell growth, altered PKM iso2(DISRUPTS); PKM(INDUCES); PKM(DISRUPTS) 19920251; 23640882; 31988148; 32101747; 33984439; 35637461; 36244646; 36348389; 36450257; 37126714; 37196116 29 33 414 -APP APP iso4 Apoptosis; Cell surface; Membrane protein, integral; Receptor, misc.; Transcription factor P05067-4 351 21q21.3 human T668-p 448523 VEVDAAVtPEERHLS APP_amyloid protein stabilization; molecular association, regulation; protein processing; intracellular localization; phosphorylation apoptosis, altered; exocytosis, altered; transcription, induced; cytoskeletal reorganization; transcription, altered; cell growth, altered Fe65(DISRUPTS); TFCP2(INDUCES); APBA2(INDUCES); Fe65(INDUCES); PIN1(INDUCES); 14-3-3 gamma(DISRUPTS) 10341243; 11517218; 14970211; 15178331; 15944381; 16223726; 16554819; 16705182; 17085446; 17459339; 18833287; 21947912; 24610780 39 5 3 necessary for intraneuronal AB accumulation which leads to cell death (neurotoxicity); regulates Tau and GSK3B phosphorylation -SUV39H1 SUV39H1 Amino Acid Metabolism - lysine degradation; EC 2.1.1.43; METHYLTRANSFERASE; Methyltransferase; Methyltransferase, protein lysine O43463 6839 Xp11.23 human K105-m1 63128910 LRRHHRSkTPRHLDP enzymatic activity, inhibited chromatin organization, altered; cell growth, inhibited; transcription, induced 23509280 1 1 0 facilitated genomic instability -NR4A1 Nur77 Apoptosis; DNA-binding; Nuclear receptor P22736 3164 12q13.13 human S54-p 41583606 PTALPSFsTFMDGYT cell motility, induced; cell growth, induced; cytoskeletal reorganization 26155943 1 0 0 required for increase in cell growth, cell motility, monolayer permeability, and formation of actin stress fibers. -Cux1 CUTL1 DNA-binding; Membrane protein, integral; Transcription factor P53564 13047 5 G2|5 75.96 cM mouse S1155-p 457411 ILGLTQGsVSDLLAR CUT molecular association, regulation transcription, altered DNA(DISRUPTS) 9446557 1 0 0 -AURKA AurA EC 2.7.11.1; KINASE; Kinase, protein; Oncoprotein; Protein kinase, Other; Protein kinase, Ser/Thr (non-receptor) O14965 6790 20q13.2 human S284-p 2370900 WSVHAPSsRRTTLCG Pkinase enzymatic activity, induced 16785988 2 0 0 -ARHGAP35 GRF-1 GAP; GAP, Rac/Rho; Motility/polarity/chemotaxis; Transcription factor; Tumor suppressor Q9NRY4 2909 19q13.32 human T1173-p 3213723 GRFASYRtSFSVGSD RhoGAP_pG1_pG2 molecular association, regulation; activity, inhibited RND1(DISRUPTS) 19103606 1 3 0 -Bach2 BACH2 DNA-binding; Transcription factor P97303 12014 4|4 A5 mouse K579-sm 2798315 NQVRPQIkCEQSYGT intracellular localization transcription, inhibited 15060166 2 0 0 formation of PML bodies -BORA BORA Activator Q6PGQ7 79866 13q21.33 human S497-p 2512942 SSNIQMDsGYNTQNC protein degradation; molecular association, regulation cell cycle regulation BTRC(INDUCES) 18378770; 18521620; 34759346 3 0 0 -Ctnnd1 CTNND1 iso3 Actin-binding; Adaptor/scaffold; Cell adhesion; G protein regulator, misc.; Motility/polarity/chemotaxis P30999-3 12388 2 D|2 49.45 cM mouse Y280-p 450398 HRFHPEPyGLEDDQR cell cycle regulation; cell motility, altered 18515860 2 18 210 -Mnx1 MNX1 DNA-binding Q9QZW9 15285 5|5 B1 mouse S78-p 3191341 GDRLRAEsPSPPRLL molecular association, regulation; intracellular localization cell motility, altered; transcription, inhibited NONO(INDUCES) DNA(INDUCES) 24425879; 26342078 2 17 1 nuclear localization; nuclear localization, inhibits Cbl-b transcription -JUN Jun Oncoprotein; Transcription factor P05412 3725 1p32.1 human S243-p 450451 PGETPPLsPIDMESQ molecular association, regulation; ubiquitination; activity, inhibited; phosphorylation transcription, altered FBXW7(INDUCES); FBXW7(DISRUPTS); SP1(DISRUPTS) 1516134; 16023596; 17215518; 1846781; 21860413 13 25 18 -KRT18 K18 Cytoskeletal; Nucleolus P05783 3875 12q13.13 human K372-sm 25027603 ALLNIKVkLEAEIAT Filament cytoskeletal reorganization 21062750 1 1 0 sumoylation regulate solubility; modified by poly-SUMO-2/3 chains, oxidative stress, apoptosis, and/or phosphatase inhibition increase sumoylation in primary hepatocytes; K to R mutants show filament disorganization -CCDC6 CCDC6 Apoptosis; Cytoskeletal; Oncoprotein Q16204 8030 10q21.2 human K424-sm 27992505 SNSPDKFkRPTPPPS intracellular localization transcription, induced; signaling pathway regulation 23145146 1 0 0 cyclic AMP activity -Wasl N-WASP Adaptor/scaffold; Motility/polarity/chemotaxis O08816 682507 4q22 rat S480-p 3149548 KRSKAIHsSDEDEDD endocytosis, induced; cytoskeletal reorganization 21610097 4 19 2 Phosphorylation induces CK2-A1 and N-WASP complex formation and regulate cell surface EGFR levels by endocytosis. Phosphorylation reduces actin polymerization. -CARD11 CARD11 Adaptor/scaffold Q9BXL7 84433 7p22.2 human S615-p 5403700 RYSFGPSsIHSSSSS cell growth, inhibited; transcription, induced; transcription, inhibited; signaling pathway regulation 19118383; 26551667 3 0 0 NF-kB pathway, NF-kB transcription inhibited, lymphocyte proliferation decreased; Ser615Phe mutation increased NF-?B luciferase reporter activity -Cdk5 CDK5 Cell cycle regulation; EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, CMGC; Protein kinase, Ser/Thr (non-receptor) Q03114 140908 4q11 rat Y15-p 448022 EKIGEGTyGTVFKAK Pkinase apoptosis, inhibited; cell motility, altered 18701695; 35069828 17 47 894 -CDCA8 Borealin Cell cycle regulation; Nucleolus Q53HL2 55143 1p34.3 human T278-p 482837 QICSSIRtHK_____ cell growth, altered 17483322 1 0 0 -Prkcz PKCZ EC 2.7.11.13; KINASE; Kinase, protein; Protein kinase, AGC; Protein kinase, Ser/Thr (non-receptor) P09217 25522 5q36 rat T560-p 447572 TSEPVQLtPDDEDVI Pkinase_C protein degradation; phosphorylation; enzymatic activity, induced cytoskeletal reorganization desmin(DISRUPTS); TNNT1(DISRUPTS); TPM1(INDUCES); MYO1C(INDUCES); TNNI1(DISRUPTS) 11141077; 14580237; 17724026 13 8 0 -LIG1 LIG1 DNA repair, damage; EC 6.5.1.1; Ligase P18858 3978 19q13.33 human K226-ub 22246884 KPPRRAPkTLSSFFT protein degradation 27573245 1 2 0 -Thra TR-alpha DNA-binding; Nuclear receptor; Transcription factor P63058 21833 11 D|11 62.58 cM mouse K288-sm 38557703 AVKREQLkNGGLGVV Hormone_recep intracellular localization cell cycle regulation; cell growth, induced; transcription, induced DNA(INDUCES) 34916557 2 0 0 mutant mice had reduced fat stores on normal chow, and was reduced, more on high fat diets ; reduced CREB and AP1-mediated gene expression, reduced TR-alpha?CREB interaction in mutant preadipocytes; decreased preadipocyte proliferation, reduced white adipose stores and adipocyte cell diameter in mutant mice; (K283Q/K288R)-/- mutant: reduced nuclear localization of cyclin D1, cyclin D2, Cdk4 and Cdk2 in human primary preadipocytes -VAV1 VAV1 iso2 GEF; GEF, Rac/Rho; Motility/polarity/chemotaxis; Oncoprotein P15498-2 7409 19p13.3 human S748-p 12084454 ISRPAVGsTKYFGTA carcinogenesis, inhibited; signaling pathway regulation 30131370 0 3 1 -Nefm NFM Cytoskeletal P08553 18040 14|14 D1 mouse S610-p 448044 AKSPMPKsPVEEVKP cytoskeletal reorganization 19193875 3 29 24 slightly altered axoplasmic organization in 7S/A mice mutant -SPECC1L SPECC1L Cell cycle regulation Q69YQ0 23384 22q11.23 human S1003-p 23147747 EERKDPLsALAREYG cytoskeletal reorganization 36634848 1 2 1 -AKT1 Akt1 EC 2.7.11.1; KINASE; Kinase, protein; Oncoprotein; Protein kinase, AGC; Protein kinase, Ser/Thr (non-receptor) P31749 207 14q32.33 human Y474-p 447859 PHFPQFSySASGTA_ Pkinase_C enzymatic activity, induced 12149249 2 1 13 -ACLY ACLY Carbohydrate Metabolism - citrate (TCA) cycle; EC 2.3.3.8; Lyase; Transferase P53396 47 17q21.2 human K554-ub 59144801 EILIPVFkNMADAMR CoA_binding protein degradation carcinogenesis, inhibited; cell growth, inhibited 27664236 1 1 0 -CRYAB CRYAB Chaperone; Heat shock protein P02511 1410 11q23.1 human T170-gl 5281706 REEKPAVtAAPKK__ exocytosis, induced 26620801 4 4 0 -HABP4 HABP4 Transcription regulation Q5JVS0 22927 9q22.32 human K336-sm 1873147504 KYRDDMVkDDYEDDS IHABP4_N molecular association, regulation 28695742 1 0 0 Presence of SUMO-1 strongly influences the interaction of HABP4 (Ki-1/57) with other cellular proteins.; Fewer PML-nuclear bodies when compared to non-SUMOylated triple mutants, but not when treated with As2O2 -Rims1 RIMS1 Adaptor/scaffold; Vesicle Q9JIR4 84556 9q13 rat S413-p 450481 ARHERRHsDVALPHT activity, induced 14532002 4 6 0 Phosphorylation of RIM1alpha S413 is required for presynaptic LTP (long-term potentiation). -Tnnt2 TNNT2 iso2 Motility/polarity/chemotaxis; Motor P50753-2 24837 13q13 rat S199-p 451755 KAQTERKsGKRQTER Troponin protein conformation 24708997 9 0 0 T204E mutant blunts Ca2+ sensitivity, PKC phosphorylation of these residues can increase or decrease Ca2+ sensitivity and cardiac regulation -Rhoa RHOA G protein; G protein, monomeric; G protein, monomeric, Rho; Motility/polarity/chemotaxis; Oncoprotein Q9QUI0 11848 9|9 F1-F2 mouse S26-p 484601 TCLLIVFsKDQFPEV Ras activity, inhibited cytoskeletal reorganization; cell motility, inhibited 24872548 1 2 0 abnormal morphology-neuronal polarity and processes -Prkce PKCE EC 2.7.11.13; KINASE; Kinase, protein; Protein kinase, AGC; Protein kinase, Ser/Thr (non-receptor) P16054 18754 17|17 E4 mouse S368-p 2085101 NNIRKALsFDNRGEE molecular association, regulation 14-3-3 beta(INDUCES) 18237277 3 17 0 -Dnm1 DYN1 EC 3.6.5.5; Hydrolase; Microtubule-binding; Motility/polarity/chemotaxis; Motor; Vesicle P21575 140694 3p12 rat S857-p 455277 ASPSRPEsPRPPFDL molecular association, regulation; intracellular localization amphiphysin(DISRUPTS) 22857010 4 10 0 -DGCR8 DGCR8 Nucleolus; RNA processing; RNA-binding Q8WYQ5 54487 22q11.21 human T279-p 3208092 DHPSDGEtSVQPMMT protein stabilization 24239349 0 6 0 -RAP1B RAP1B G protein; G protein, monomeric; G protein, monomeric, Ras P61223 327708 cow S179-p 451799 PGKARKKsSCQLL__ intracellular localization; activity, inhibited cell motility, induced RASSF5(DISRUPTS) 23946483 8 1 0 1) Cytosolic relocalization of Rap1 is phosphorylation dependent. 2) Rap1 phosphorylation is necessary for cell migration. 3) Binding of Rap1 to RapL is decreased by PKA-dependent phosphorylation of S180. -Apbb2 ZFRA Q6DQH2 mouse S8-p 2868604 MSSRRSSsCKYCEQD PyrI_C molecular association, regulation; intracellular localization carcinogenesis, inhibited; apoptosis, induced ZFRA(INDUCES) 17567906; 18403180; 25686832 3 0 0 self-polymerization of wt Zfra blocks cancer growth in vivo; translocation of Zfra, WWOX, and p53 to mitochondria -XRCC5 Ku80 DNA-binding; EC 3.6.1.-; EC 3.6.4.-; Helicase; Nuclear receptor co-regulator; Nucleolus; RNA-binding P13010 7520 2q35 human K544-ub 12403528 FPLIEAKkKDQVTAQ Ku_C molecular association, regulation DNA repair, induced DNA(DISRUPTS) 27895153 1 0 3 -EPHA3 EphA3 EC 2.7.10.1; KINASE; Kinase, protein; Membrane protein, integral; Protein kinase, TK; Protein kinase, tyrosine (receptor) P29320 2042 3p11.1 human S768-p 7445291 KVSDFGLsRVLEDDP PK_Tyr_Ser-Thr protein conformation 18547520 1 3 0 -DCX Doublecortin iso2 Cytoskeletal; Motility/polarity/chemotaxis O43602-2 1641 Xq23 human S306-p 454122 GPMRRSKsPADSANG intracellular localization cell growth, inhibited; cytoskeletal reorganization 22359282 1 2 5 decreases process outgrowth in neurons -MAP3K1 MEKK1 EC 2.7.11.25; KINASE; Kinase, protein; Ligase; Protein kinase, STE; Protein kinase, Ser/Thr (non-receptor); UBIQUITIN LIGASE; Ubiquitin conjugating system; Ubiquitin ligase Q13233 4214 5q11.2 human S67-p 3053616 RQLRKVRsVELDQLP molecular association, regulation JNK1(DISRUPTS) 12228228 2 2 0 -EPS8 EPS8 Adaptor/scaffold Q12929 2059 12p12.3 human Y485-p 450732 EHSSVSEyHPADGYA cell cycle regulation; cell motility, induced 32641864 2 15 141 -MORC2 MORC2 DNA-binding Q9Y6X9 22880 22q12.2 human T556-gl 1879871300 TFRKDMKtQEEKQKQ transcription, induced 34974534 1 0 0 enhances promoter activities of SNAIL and CTGF -Kcnj5 GIRK4 Channel, potassium; Membrane protein, integral; Membrane protein, multi-pass P48545 16521 9 A4|9 17.65 cM mouse S418-p 1884003506 VSQATRGsM______ activity, induced; molecular association, regulation Other(INDUCES) 36584301 1 0 0 induces binding to PIP2 -Ppp2r5b PPP2R5B Motility/polarity/chemotaxis; Protein phosphatase, regulatory subunit Q6PD28 225849 19|19 A mouse S32-p 31895400 PDKVDGFsRRSLRRA molecular association, regulation; phosphorylation PPP2CA(INDUCES); PPP2R5B(INDUCES) 21329884 1 0 0 PPP2R2R5B phosphorylation by CLK2 is required for the PPP2CA-AKT complex; induces AKT dephosphorylation -FHOD1 FHOD1 Actin-binding Q9Y613 29109 16q22.1 human T1141-p 2035402 NRKSLRRtLKSGLGD activity, induced cell motility, induced; cell adhesion, induced; cytoskeletal reorganization; cell growth, altered FHOD1(DISRUPTS) 18239683; 21106951; 24331927 3 2 1 autoinhibitory interaction between C- and N-terminal part of FHOD1 is attenuated in S1130D/S1136D/T1140D triple mutant; induce actin polymerization -PAGE4 PAGE4 Cancer Testis Antigen (CTA) O60829 9506 Xp11.23 human S7-p 63280104 _MSARVRsRSRGRGD GAGE protein conformation 28289210 1 1 0 -Hspb6 HSP20 Chaperone; Heat shock protein Q5EBG6 243912 7|7 B1 mouse S10-p 36703149 IPVPVQPsWLRRASA Crystallin apoptosis, inhibited; transcription, inhibited 32218573 1 1 0 decreased ANP mRNA expression -Pde4a PDE4A EC 3.1.4.53; Nucleotide Metabolism - purine; Phosphodiesterase P54748 25638 8q13 rat S140-p 458389 TTSQRREsFLYRSDS protein conformation; enzymatic activity, induced 21323643 4 20 1 -PTPRA PTPRA EC 3.1.3.48; Membrane protein, integral; Motility/polarity/chemotaxis; PHOSPHATASE; Receptor protein phosphatase, tyrosine P18433 5786 20p13 human Y798-p 447613 YIDAFSDyANFK___ enzymatic activity, induced cytoskeletal reorganization 9439605 17 85 2339 Y798F mutant showed a different morphology compared to wild-type. -MRE11 MRE11A Cell cycle regulation; DNA repair, damage; DNA-binding; Deoxyribonuclease P49959 4361 11q21 human R572-m2 62978401 ATNKGRGrGRGRRGG DNA repair, altered 15741314 0 1 0 -SKAP1 SKAP55 Adaptor/scaffold; Motility/polarity/chemotaxis Q86WV1 8631 17q21.32 human Y271-p 455436 EKEEEDIyEVLPDEE molecular association, regulation GRB2(INDUCES); Fyn(INDUCES) 12171928 1 5 132 SKAP55-Y271F mutant abolished the enhancing effect of wild-type SKAP55 on MAPK activation after TCR cross-linking. -Havcr2 TIM-3 Membrane protein, integral; Receptor, misc. Q8VIM0 171285 11|11 B1.1 mouse Y256-p 470136 IRSEENIyTIEENVY molecular association, regulation BAT3(DISRUPTS) 22863785 5 0 0 -PRKCE PKCE EC 2.7.11.13; KINASE; Kinase, protein; Protein kinase, AGC; Protein kinase, Ser/Thr (non-receptor) Q02156 5581 2p21 human K321-ub 27852601 TNSGQRRkKLIAGAE molecular association, regulation carcinogenesis, induced; transcription, induced; signaling pathway regulation IKKG(INDUCES) 23123196 1 0 0 regulation of NF-kB and EGFR pathways in PKM2 upregulation and tumorigenesis -SPTA1 SPTA1 Cytoskeletal; Motility/polarity/chemotaxis P02549 6708 1q23.1 human Y422-p 13421405 HKHEIDSyDDRFQSA Spectrin cytoskeletal reorganization 20206558 1 1 0 -IRF3 IRF3 DNA-binding; Transcription factor Q14653 3661 19q13.33 human R285-m2 1881518207 GQWLWAQrLGHCHTY molecular association, regulation TIRAP(INDUCES); IRF3(INDUCES) 34583098 1 0 0 dimerization and enhanced its translocation to nucleus -Cdkn1a p21Cip1 Cell cycle regulation; Inhibitor P39689 12575 17 A3.3|17 15.12 cM mouse T140-p 447837 QGRKRRQtSLTDFYH protein stabilization; intracellular localization; activity, inhibited 21791608; 24848107 20 0 0 localized to cytoplasm -BUB1 BUB1 Cell cycle regulation; EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, Other; Protein kinase, Ser/Thr (non-receptor) O43683 699 2q13 human T589-p 3175277 WGIRCNKtLAPSPKS intracellular localization 26399325 1 3 0 T589 autophosphorylation limits H2A-pT120 and SGO1 to centromeres -NFE2L1 NFE2L1 DNA-binding; Transcription factor Q14494 4779 17q21.32 human S599-p 454236 PSALKKGsKEKQADF molecular association, regulation C/EBP-beta(INDUCES) 15308669 1 0 0 -Cgas cGAS EC 2.7.7.86 Q8C6L5 214763 9|9 E1 mouse K464-sm 59117702 LECLRTEkLDHYFIP Mab-21_C activity, induced; protein stabilization 27637147 1 0 0 regulates the stability of activated cGas -EPHB1 EphB1 EC 2.7.10.1; KINASE; Kinase, protein; Membrane protein, integral; Protein kinase, TK; Protein kinase, tyrosine (receptor) P54762 2047 3q22.2 human Y778-p 450471 DDTSDPTyTSSLGGK PK_Tyr_Ser-Thr molecular association, regulation SHC1(NOT_REPORTED); Src(NOT_REPORTED) 12925710 2 4 16 -FBXO31 FBXO31 Cell cycle regulation; UBIQUITIN LIGASE; Ubiquitin conjugating system; Ubiquitin ligase Q5XUX0 79791 16q24.2 human K330-ub 573772184 GRRARGTkITGDPNI Cyclin_D1_bind protein degradation; molecular association, regulation; ubiquitination; enzymatic activity, induced CCND1(INDUCES); CCND3(INDUCES); CCND2(INDUCES) 29279382 1 1 0 promotes cyclinD1 degradation not affected by ERK2-mediated phosphorylation -Tcap Telethonin Motility/polarity/chemotaxis O70548 21393 11|11 D mouse S157-p 448693 GPLRRTLsRSMSQEA Telethonin protein stabilization; ubiquitination 34566695 4 5 3 inhibits ubiquitination -BAIAP2L1 IRTKS Adaptor/scaffold; Cytoskeletal Q9UHR4 55971 7q21.3-q22.1 human Y156-p 462515 GSRNALKyEHKEIEY IMD cell motility, induced 21840312 1 2 31 -CTNNB1 CTNNB1 Actin-binding; Cell adhesion; Motility/polarity/chemotaxis; Nuclear receptor co-regulator; Oncoprotein; Transcription factor P35222 1499 3p22.1 human T112-p 3075001 EGMQIPStQFDAAHP protein degradation; intracellular localization cell growth, inhibited; cell motility, altered; transcription, induced; cell motility, inhibited CTNNA1(INDUCES) 12432063; 19141652 3 0 0 -L1CAM NCAM-L1 Cell adhesion; Membrane protein, integral P32004 3897 Xq28 human T1247-p 485892 GNDSSGAtSPINPAV molecular association, regulation 21080252 1 6 0 mutation of T1247 and S1248, alone or together had little effect on C20 binding -NFE2L2 NRF2 DNA-binding; Transcription factor Q16236 4780 2q31.2 human T369-p 1876350200 ESSSYGDtLLGLSDS protein degradation; ubiquitination; intracellular localization apoptosis, induced; transcription, inhibited 35108418 1 0 0 -PPP1R3F PPP1R3F Membrane protein, integral; Protein phosphatase, regulatory subunit Q6ZSY5 89801 Xp11.23 human S420-p 22650300 PAIRIPPsSPLCGLG signaling pathway regulation 21668450 0 1 0 regulation of glycogen synthesis via R3F-PP1 signaling in astrocytoma cells -FBP1 FBPase Carbohydrate Metabolism - fructose and mannose; Carbohydrate Metabolism - glycolysis and gluconeogenesis; Carbohydrate Metabolism - pentose phosphate pathway; EC 3.1.3.11; Mitochondrial; Phosphatase (non-protein) P09467 2203 9q22.32 human S170-p 1880113501 AGYALYGsATMLVLA molecular association, regulation; intracellular localization carcinogenesis, inhibited; apoptosis, induced; transcription, altered H3(INDUCES); PPAR-alpha(INDUCES); KPNA4(INDUCES); FBPase(DISRUPTS) 36266488 2 1 0 dephosphorylates H3 -Krt8 K8 Cytoskeletal P11679 16691 15 F2|15 57.2 cM mouse S80-p 448539 TVNQSLLsPLKLEVD Keratin_2_head molecular association, regulation; intracellular localization carcinogenesis, induced; apoptosis, inhibited; cytoskeletal reorganization 10623656; 16563375; 16818723; 33847415 29 8 9 -Smo SMO Cell development/differentiation; GPCR, Fz/Smo family; Membrane protein, integral; Membrane protein, multi-pass; Oncoprotein; Receptor, GPCR P56726 319757 6 A3.3|6 12.36 cM mouse S642-p 1872776120 AILPQDVsVTPVATP molecular association, regulation transcription, induced PKACA(INDUCES) 33886552 1 1 0 -PRKAR1A PKAR1A Protein kinase, regulatory subunit P10644 5573 17q24.2 human S83-p 450936 DSREDEIsPPPPNPV molecular association, regulation; enzymatic activity, inhibited cell cycle regulation; carcinogenesis, induced PKACA(INDUCES); RFC2(DISRUPTS); MYO10(INDUCES) 16582606; 23942052; 25605337; 35977512; 36114575 5 111 240 -MASTL MASTL EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, AGC; Protein kinase, Ser/Thr (non-receptor) Q96GX5 84930 10p12.1 human T860-p 58984001 QPDDETDtSYFEARN protein conformation 21444715 1 1 0 -Csf1r CSFR EC 2.7.10.1; KINASE; Kinase, protein; Membrane protein, integral; Oncoprotein; Protein kinase, TK; Protein kinase, tyrosine (receptor) P09581 12978 18 E1|18 34.41 cM mouse Y721-p 448364 SSQGVDTyVEMRPVS PK_Tyr_Ser-Thr molecular association, regulation; enzymatic activity, induced; phosphorylation carcinogenesis, induced; cell motility, induced; cell adhesion, induced; signaling pathway regulation; cell differentiation, altered; cell motility, altered; cytoskeletal reorganization; transcription, inhibited; cell growth, altered PLCG1(INDUCES); SOCS1(INDUCES); PIK3R1(INDUCES) 11297560; 17420256; 18519746; 21610095; 23648053; 7545432; 8262059; 9312046 15 0 1 -Cbx3 CBX3 DNA-binding Q5RJK5 297093 4q24 rat S93-p 457001 KDGTKRKsLSDSESD protein degradation; intracellular localization cell differentiation, induced; transcription, induced 30305677 5 57 61 regulation of expression of distinct gene subset -IRF3 IRF3 DNA-binding; Transcription factor Q14653 3661 19q13.33 human S386-p 448684 ARVGGASsLENTVDL activity, induced; molecular association, regulation; intracellular localization; protein conformation; enzymatic activity, induced; phosphorylation apoptosis, inhibited; transcription, induced; transcription, altered IRF3(INDUCES); p300(INDUCES); CBP(INDUCES) 10920266; 14703513; 17526488; 18272581; 18440553; 20511230; 20604809; 31882361; 34799452; 35879450; 35948267; 9463386 26 8 0 -Gja1 GJA1 Channel, misc.; Membrane protein, integral; Membrane protein, multi-pass; Motility/polarity/chemotaxis P08050 24392 20q11 rat Y313-p 454254 SEQNWANySAEQNRM Connexin43 molecular association, regulation cytoskeletal reorganization CTNNB1(DISRUPTS) 29882937; 32956670 5 20 298 regulation of gap junction intercellular communication -DES desmin Cytoskeletal; Motility/polarity/chemotaxis P17661 1674 2q35 human T17-p 449613 RVSSYRRtFGGAPGF Filament_head cytoskeletal reorganization 12686604 1 3 1 Mutated desmin sites showed failure of desmin filaments to segregate into daughter cells. -ATM ATM DNA repair, damage; EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, Ser/Thr (non-receptor); Protein kinase, atypical; Tumor suppressor Q13315 472 11q22.3 human T86-p 481862 KPNVSAStQASRQKK TAN molecular association, regulation; enzymatic activity, inhibited; protein conformation cell cycle regulation; apoptosis, inhibited MRE11A(DISRUPTS); NBS1(DISRUPTS) 27939942 1 1 0 -Eif2ak1 HRI EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, Other; Protein kinase, Ser/Thr (non-receptor); Translation Q9Z2R9 15467 5|5 G2 mouse T485-p 447595 GKGTRTHtSRVGTCL Pkinase phosphorylation; enzymatic activity, induced 12767237 1 1 0 -EIF4ENIF1 4E-T Karyopherin; Nuclear import; Translation Q9NRA8 56478 22q12.2 human S301-p 14572931 DAVLPEQsPGDFDFN EIF4E-T molecular association, regulation 4E-T(INDUCES) 22966201 1 13 7 required for processing bodies (PBs or P bodies) assembly -Igf2bp1 IGF2BP1 RNA-binding; Translation O88477 140486 11 D|11 59.08 cM mouse S181-p 453893 RGQPRQGsPVAAGAP molecular association, regulation RNA splicing, induced; cell growth, induced; translation, induced RNA(INDUCES) 23388827 3 59 12 -KCNQ1 Kv7.1 Channel, potassium; Membrane protein, integral; Membrane protein, multi-pass P51787 3784 11p15.5-p15.4 human S468-p 2999201 YDSSVRKsPTLLEVS activity, induced 12835205 1 1 0 -Septin5 SEPT5 Cell cycle regulation; Cytoskeletal; Hydrolase; Vesicle Q9JJM9 116728 11q23 rat S327-p 454379 TQDSRMEsPIPILPL molecular association, regulation exocytosis, altered STX1A(DISRUPTS) 18385322 2 27 2 -Csk CSK EC 2.7.10.2; KINASE; Kinase, protein; Protein kinase, TK; Protein kinase, tyrosine (non-receptor) P41241 12988 9 B|9 31.18 cM mouse S284-p 23096469 YLRSRGRsVLGGDCL PK_Tyr_Ser-Thr phosphorylation; enzymatic activity, induced signaling pathway regulation 31011187 1 1 2 induces phosphorylation of Lyn, regulates BCR signaling -Neurog1 neurogenin 1 Cell development/differentiation; DNA-binding; Transcription factor P70595 29410 17p14 rat S179-p 7590801 PCLPGPPsPASDTES transcription, induced; cell growth, altered 19365559 1 0 0 -Cadps CADPS Vesicle Q62717 26989 15p15 rat S5-p 7712502 ___MLDPsSSEEESD activity, induced exocytosis, altered 19460754 1 2 0 -CENPA CENPA DNA-binding P49450 1058 2p23.3 human S68-p 38520200 LIRKLPFsRLAREIC Histone protein degradation; intracellular localization cell cycle regulation 34758320 4 2 0 Ser68 facilitates degradation -HNRNPUL1 E1B-AP5 RNA splicing; RNA-binding Q9BUJ2 11100 19q13.2 human R612-me 41259008 PEKRFDNrGGGGFRG molecular association, regulation; intracellular localization NBS1(INDUCES) 26020839 1 1 0 ecruitment at sites of damage -BUB1B BUB1B EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, Other; Protein kinase, Ser/Thr (non-receptor); Tumor suppressor O60566 701 15q15.1 human T620-p 767908 RAARFVStPFHEIMS protein stabilization; molecular association, regulation; phosphorylation cell cycle regulation; cytoskeletal reorganization; signaling pathway regulation PLK1(INDUCES) 17785528; 33125045 3 0 0 induces KNL1-MELT signaling; in vitro and in vivo association with PLK1 -HIF1A HIF1A Autophagy; DNA-binding; Transcription factor Q16665 3091 14q23.2 human K391-sm 2793906 SSLFDKLkKEPDALT protein stabilization transcription, induced; transcription, inhibited 15465032; 19680224 2 1 0 -Zc3hc1 NIPA Cell cycle regulation; Ubiquitin conjugating system Q80YV2 232679 6|6 A3.3 mouse S353-p 449745 PIVSRTRsWESSSPV molecular association, regulation cell cycle regulation CUL1(DISRUPTS) 22955283 4 41 32 ERK2 phosphorylation at G2/M is sufficient dissociation of SCF core complex at G2/M. -PARP1 PARP1 DNA repair, damage; EC 2.4.2.30; Nuclear envelope; Nuclear receptor co-regulator; Nucleolus; Transferase P09874 142 1q42.12 human Y992-p 1875398902 LYNEYIVyDIAQVNL PARP cell cycle regulation; carcinogenesis, induced; cell growth, induced; apoptosis, inhibited 34762994 1 0 0 -Grin1 NMDAR1 Channel, calcium; Channel, ligand-gated; Membrane protein, integral; Membrane protein, multi-pass P35439 24408 3p13 rat S889-p 449107 AITSTLAsSFKRRRS molecular association, regulation Calmodulin(DISRUPTS) 9252405 4 0 1 -SLC6A4 SERT Membrane protein, integral; Membrane protein, multi-pass; Transporter P31645 6532 17q11.2 human T613-p 7576401 ERIIKSItPETPTEI molecular association, regulation; intracellular localization Vimentin(DISRUPTS) 19270731 1 0 1 -Traf2 TRAF2 Autophagy; EC 6.3.2.-; Ligase; UBIQUITIN LIGASE; Ubiquitin conjugating system; Ubiquitin ligase P39429 22030 2|2 A3 mouse S11-p 5397201 ASVTSPGsLELLQPG cell differentiation, altered 34910106 6 15 0 -TP53RK PRPK EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, Other; Protein kinase, Ser/Thr (non-receptor) Q96S44 112858 20q13.12 human S250-p 1981300 RLRGRKRsMVG____ enzymatic activity, induced carcinogenesis, induced; cell motility, induced; signaling pathway regulation 17712528; 28412249; 29904102 3 0 7 PBK/PRPK pathway; promoting metastasis -GUCA1B GCAP2 Calcium-binding P51177 286851 cow S201-p 455322 ISQQRRKsAMF____ molecular association, regulation; intracellular localization 14-3-3 epsilon(INDUCES) 25058152 3 0 0 proximal rod compartments -TAB1 TAB1 Activator; Motility/polarity/chemotaxis Q15750 10454 22q13.1 human K294-ub 1881312003 LMSEGLYkALEAAHG signaling pathway regulation 34017102 1 0 0 TRIM26 enhances TLRs-induced NF-kB and MAPK signaling. -USP2 USP2 DEUBIQUITINASE; EC 3.4.19.12; Protease; Ubiquitin-specific protease O75604 9099 11q23.3 human S207-p 803501400 ENYGRKGsASQVPSQ molecular association, regulation 29490279 1 1 0 disassociation of phosphorylated R-SMADs from the receptor complex; USP2a promotes TGF-beta-induced EMT and metastasis -PRKDC DNAPK DNA repair, damage; EC 2.7.11.1; KINASE; Kinase, protein; Nucleolus; Protein kinase, Ser/Thr (non-receptor); Protein kinase, atypical P78527 5591 8q11.21 human S2672-p 3193631 DPLVDHTsPSSDSLL DNAPKcs_CC5 DNA repair, inhibited 24687855 1 3 0 cell survival inhibited -CXCR4 CXCR4 GPCR, family 1; Membrane protein, integral; Membrane protein, multi-pass; Receptor, GPCR P61073 7852 2q22.1 human S324-p 6140803 LTSVSRGsSLKILSK receptor desensitization, induced; receptor internalization, induced; protein degradation; molecular association, regulation; enzymatic activity, induced; activity, induced; ubiquitination; intracellular localization endocytosis, induced ITCH(INDUCES) 19116316; 25355818; 30327409; 30936203; 34973340 12 11 4 -Kdr VEGFR2 EC 2.7.10.1; KINASE; Kinase, protein; Membrane protein, integral; Protein kinase, TK; Protein kinase, tyrosine (receptor) P35918 16542 5 C3.3|5 40.23 cM mouse Y949-p 447903 RFRQGKDyVGELSVD PK_Tyr_Ser-Thr molecular association, regulation; intracellular localization carcinogenesis, inhibited; cell growth, inhibited; cell motility, altered; cytoskeletal reorganization Src(DISRUPTS); TSAd(INDUCES); CDH5(DISRUPTS) 15962004; 33726754 20 0 3 regulates VE-Cadherin localization -CC2D1A CC2D1A Transcription factor Q6P1N0 54862 19p13.12 human S208-p 483763 PASTPTYsPAPTQPA molecular association, regulation cell cycle regulation RAD21(INDUCES) 20171170 2 15 21 -POLH POLH DNA repair, damage; EC 2.7.7.7; Transferase Q9Y253 5429 6p21.1 human K163-sm 62518201 TAEETVQkEGMRKQG IMS enzymatic activity, inhibited; intracellular localization 27811911; 32350109 2 1 0 -PDCD4 PDCD4 Apoptosis; Tumor suppressor Q53EL6 27250 10q25.2 human S67-p 458381 KRRLRKNsSRDSGRG protein degradation; molecular association, regulation cell cycle regulation; translation, altered; cell growth, altered BTRC(INDUCES) 17053147 5 9 44 -Neurod1 NEUROD1 DNA-binding; Transcription factor Q64289 29458 3q24 rat S274-p 465680 PSFDGPLsPPLSING Neuro_bHLH intracellular localization 12297313; 25752781 3 0 0 -TFEB TFEB DNA-binding; Transcription factor P19484 7942 6p21.1 human S122-p 3181616 PKPPPAAsPGVRAGH MITF_TFEB_C_3_N activity, induced; intracellular localization transcription, inhibited; cell growth, altered 28055300; 29945972 5 37 0 -TP53 p53 Activator; DNA-binding; Motility/polarity/chemotaxis; Nuclear receptor co-regulator; Transcription factor; Tumor suppressor P04637 7157 17p13.1 human K101-ub 486292 SSSVPSQkTYQGSYG P53 protein degradation; intracellular localization 17371868; 31492752 2 3 0 -TRIM21 TRIM21 EC 6.3.2.-; Ligase; UBIQUITIN LIGASE; Ubiquitin conjugating system; Ubiquitin ligase P19474 6737 11p15.4 human Y393-p 25120401 QKYEAGTyPQTPLHL SPRY activity, induced; molecular association, regulation IRF3(INDUCES) 22479513 1 0 0 -Trhr TRHR GPCR, family 1; Membrane protein, integral; Membrane protein, multi-pass; Receptor, GPCR Q01717 25570 7q31 rat S383-p 465594 YVSTTKVsFDDTCLA receptor internalization, altered 11278484 1 0 0 S383, T365, T371 are important for the receptor internalization -ELF4 ELF4 DNA-binding; Oncoprotein; Transcription factor Q99607 2000 Xq26.1 human K657-sm 3470700 FNPTSLIkMEPHDI_ molecular association, regulation transcription, inhibited DNA(DISRUPTS) 16904644 1 1 0 -SAV1 SAV1 Adaptor/scaffold Q9H4B6 60485 14q22.1 human S36-p 21507300 LLRNLMPsFIRHGPT protein conformation apoptosis, induced 21944251 1 3 1 self-dimerization; increase in protein level -Cebpa C/EBP-alpha DNA-binding; Transcription factor P05554 24252 1q21 rat S21-p 448308 PMSSHLQsPPHAPSN molecular association, regulation cell cycle regulation; cell growth, inhibited; cell differentiation, induced; transcription, inhibited E2F3(INDUCES); E2F2(INDUCES) 22212957 10 1 0 E2F-dependent transactivation -EIF2AK2 PKR EC 2.7.10.2; EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, Other; Protein kinase, Ser/Thr (non-receptor); Protein kinase, tyrosine (non-receptor); Translation P19525 5610 2p22.2 human S83-p 3181640 NKEKKAVsPLLLTTT enzymatic activity, induced carcinogenesis, induced; cell motility, induced; cell growth, induced; apoptosis, inhibited 11152499; 34799660 2 12 3 -ITGA4 ITGA4 Cell adhesion; Membrane protein, integral; Motility/polarity/chemotaxis; Receptor, misc. P13612 3676 2q31.3 human Y1024-p 7705802 NRRDSWSyINSKSND molecular association, regulation cytoskeletal reorganization; cell motility, inhibited PXN iso2(INDUCES); PXN(INDUCES) 19401330; 23979717 3 2 5 rescued by Rac1 inhibition -MTHFD1 MTHFD1 Carbohydrate Metabolism - glyoxylate and dicarboxylate; Cofactor and Vitamin Metabolism - one carbon pool by folate; EC 1.5.1.5; EC 3.5.4.9; EC 6.3.4.3; Hydrolase; Ligase; Mitochondrial; Oxidoreductase P11586 4522 14q23.3 human K223-sm 63343000 TGQPEMVkGEWIKPG THF_DHG_CYH_C protein degradation; ubiquitination; intracellular localization 28265077 1 0 0 -CASP6 CASP6 Apoptosis; EC 3.4.22.59; Protease P55212 839 4q25 human C264-pa 60885600 SQRRVDFcKDPSAIG Peptidase_C14 molecular association, regulation; enzymatic activity, inhibited; protein conformation 27911442 1 0 0 Palmitoylation inhibits CASP6 activity by blocking substrate binding site and dimerization. -Clip1 Restin Cytoskeletal Q9JK25 65201 12q16 rat S319-p 2509335 ASSLSSMsSVASSVS molecular association, regulation; protein conformation TUBA1C(DISRUPTS) 20519438 1 2 0 -PELP1 PELP1 Nuclear receptor co-regulator; Transcription, coactivator/corepressor Q8IZL8 27043 17p13.2 human K826-sm 1872504900 ASPPVPAkEEPEELP intracellular localization 21326211 1 0 0 regulates nucleolar partioning of ribosome biogenesis complex and determines the rate of ribosome formation -CSF2RB CSF2RB Membrane protein, integral; Receptor, cytokine P32927 1439 22q12.3 human Y882-p 2358800 KALKQQDyLSLPPWE activity, induced transcription, altered; cell growth, altered 10329850 2 0 0 -Cacnb1 CACNB1 Channel, calcium P54283 50688 10q31 rat S348-p 459046 IVYIKITsPKVLQRL Guanylate_kin activity, induced 16406008 1 0 0 -IREB2 IREB2 RNA-binding; Translation P48200 3658 15q25.1 human S157-p 2850010 LQKAGKLsPLKVQPK molecular association, regulation translation, altered RNA(DISRUPTS) 18574241 1 12 0 regulates the iron-independent synthesis of ferritin -YWHAB 14-3-3 beta Adaptor/scaffold P31946 7529 20q13.12 human K122-ac 3649439 ESKVFYLkMKGDYFR 14-3-3 molecular association, regulation SYNPO(DISRUPTS) 23840712 1 5 10 -FZR1 FZR1 UBIQUITIN LIGASE; Ubiquitin conjugating system Q9UM11 51343 19p13.3 human S39-gl 55596601 TPASSPVsSPSKHGD activity, induced; molecular association, regulation CDC27(INDUCES) 27080259 1 1 0 promotes the interaction between FZR1 and APC/C subunits, enhances APC/C activity -PLK1 PLK1 EC 2.7.11.21; KINASE; Kinase, protein; Protein kinase, Other; Protein kinase, Ser/Thr (non-receptor) P53350 5347 16p12.2 human T214-p 3191824 RKKTLCGtPNYIAPE Pkinase enzymatic activity, induced cell cycle regulation; cell growth, induced 26919439 1 14 9 crucial residue for Plk1 function in mitosis -NOS3 eNOS Amino Acid Metabolism - arginine and proline; EC 1.14.13.39; Oxidoreductase Q7YSG7 397557 pig S1179-p 447884 TSRIRTQsFSLQERH enzymatic activity, induced 15333638 217 18 7 -FOXC1 FOXC1 Cell cycle regulation; Cell development/differentiation; DNA-binding; Transcription factor Q12948 2296 6p25.3 human S241-p 3195017 PSPPQPLsPAAALGS protein stabilization; molecular association, regulation carcinogenesis, induced; cell motility, induced; transcription, induced DNA(INDUCES) 31650548 1 21 1 ubiquitination and protein degradation inhibited. increased MMP10, SOX4 and SOX13 expression levels -DSN1 DSN1 Cell cycle regulation Q9H410 79980 20q11.23 human S109-p 3595501 KETNRRKsLHPIHQG MIS13 molecular association, regulation; intracellular localization cell cycle regulation MIS12(INDUCES); CENPC1(INDUCES) 18640974; 25601404; 27881301; 32027339; 34758321 8 17 4 -Slc28a2 SLC28A2 Membrane protein, integral; Membrane protein, multi-pass; Transporter; Transporter, SLC family Q62773 60423 3q35 rat S46-p 4700175 EEVTQGHsLKDGLGH intracellular localization 22136384 1 3 0 -CDKN1A p21Cip1 Cell cycle regulation; Inhibitor P38936 1026 6p21.2 human S114-p 478191 EEDHVDLsLSCTLVP protein degradation 17283049 1 0 0 ubiquitination-independent degradation -PRMT5 PRMT5 Cell cycle regulation; EC 2.1.1.125; METHYLTRANSFERASE; Methyltransferase; Methyltransferase, protein arginine; RNA processing O14744 10419 14q11.2 human Y307-p 18545700 FAKGYEDyLQSPLQP PRMT5 molecular association, regulation; enzymatic activity, inhibited carcinogenesis, altered; cell growth, altered PRMT5(DISRUPTS) 21316606 1 0 0 contributes to the mutant Jak2 V617F -induced myeloproliferative phenotype; negatively regulates hematopoietic stem/progenitor cell expansion and erythroid differentiation -Sirpa SHPS1 Cell adhesion; Cell surface; Membrane protein, integral; Motility/polarity/chemotaxis; Receptor, misc. P97710 25528 3q36 rat Y501-p 451115 PEPSFSEyASVQVQR molecular association, regulation SHP-2(INDUCES) 9535915 5 16 136 -LAT2 LAB Adaptor/scaffold; Membrane protein, integral Q9GZY6 7462 7q11.23 human Y233-p 450646 EEDGEPDyVNGEVAA LAT2 molecular association, regulation cell differentiation, altered GRB2(INDUCES); PLCG1(INDUCES) 14722116; 17993265 3 1 6 -ERBB4 HER4 EC 2.7.10.1; KINASE; Kinase, protein; Membrane protein, integral; Protein kinase, TK; Protein kinase, tyrosine (receptor) Q15303 2066 2q34 human Y875-p 2045333 LEGDEKEyNADGGKM PK_Tyr_Ser-Thr molecular association, regulation PLCG2(INDUCES) 18721752 0 1 6 -ENSA ENSA Inhibitor; Protein phosphatase, regulatory subunit O43768 2029 1q21.3 human S109-p 477819 DLPQRKSsLVTSKLA Endosulfine molecular association, regulation; protein conformation SNCA(DISRUPTS) 18973346 2 39 50 membrane binding -RFX1 RFX1 DNA-binding P22670 5989 19p13.12 human T124-p 31871835 SEASPGStASQTGVP transcription, inhibited 26041775 1 1 0 -Vcl Vinculin Cell adhesion; Cytoskeletal; Motility/polarity/chemotaxis Q64727 22330 14 A3|14 11.53 cM mouse S1033-p 451251 NAQNLMQsVKETVRE Vinculin cell adhesion, induced; cytoskeletal reorganization 24996180 2 0 0 stiffness and strain energy, activation of vinculin and force transmission in focal adhesions -DNMT1 DNMT1 Amino Acid Metabolism - cysteine and methionine; Cell development/differentiation; EC 2.1.1.37; METHYLTRANSFERASE; Methyltransferase; Methyltransferase, DNA; Transcription regulation P26358 1786 19p13.2 human K188-ac 25171004 QEESERAkSDESIKE cell cycle regulation 21947282 1 1 0 -PRDX3 PRDX3 Apoptosis; EC 1.11.1.15; Mitochondrial; Oxidoreductase P30048 10935 10q26.11 human K253-ac 36292413 ASKEYFQkVNQ____ 1-cysPrx_C apoptosis, induced PRDX3(DISRUPTS) 31655428 1 1 0 inhibits dimerization, H2O2 induced the dimerization -Stk17b DRAK2 EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, CAMK; Protein kinase, Ser/Thr (non-receptor) Q8BG48 98267 1|1 C1.1 mouse S12-p 1851300 RFDCRSVsGLLTTTP activity, induced 17182616 2 4 0 Ca(2+) mobilization -Opn4 melanopsin GPCR, family 1; Membrane protein, integral; Membrane protein, multi-pass; Receptor, GPCR Q9QXZ9 30044 14|14 B mouse S391-p 1868515100 STHRSTLsSQSSDLS molecular association, regulation; protein conformation ARRB1(INDUCES) 32236094 1 1 0 -Cux1 CUTL1 DNA-binding; Membrane protein, integral; Transcription factor P53564 13047 5 G2|5 75.96 cM mouse S583-p 457409 VLGLSQGsVSEILAR CUT molecular association, regulation transcription, altered DNA(DISRUPTS) 9446557 1 0 1 -Pdpk1 PDK1 EC 2.7.11.1; KINASE; Kinase, protein; Nuclear receptor co-regulator; Protein kinase, AGC; Protein kinase, Ser/Thr (non-receptor) O55173 81745 10q12 rat Y9-p 447696 ARTTSQLyDAVPIQS enzymatic activity, induced translation, altered; cell adhesion, altered 18559349 5 1 6 Induces fibronectin expression and deposition and increases AngII mesangial cell hypertrophy -Mtor mTOR Autophagy; EC 2.7.11.1; KINASE; Kinase, protein; Motility/polarity/chemotaxis; Protein kinase, Ser/Thr (non-receptor); Protein kinase, atypical Q9JLN9 56717 4 E2|4 78.76 cM mouse S2481-p 447498 TVPESIHsFIGDGLV acetylation; intracellular localization; phosphorylation; enzymatic activity, induced 20022946; 33547375 69 29 1 decreases acetylation of HSP90 by increasing HDAC6 expression, thereby affecting Cx43 localization; induces HDAC6 phosphorylation -CDKN2A p14ARF SUMO LIGASE; SUMO conjugating system Q8N726 1029 9p21.3 human T8-p 27523604 MVRRFLVtLRIRRAC P19Arf_N protein stabilization; intracellular localization cell growth, induced; cell adhesion, altered 23308265; 25723571; 29728595 3 0 0 ARF accumulation in the cytoplasm; mediate both cell spreading and FAK activation; T8-p induces accumulation of the protein both in the cytoplasm and in the nucleus. Cytoplasmic localized ARF is phosphorylated.; T8D mutant localized in cytoplasm -Pparg PPAR-gamma DNA-binding; Nuclear receptor; Transcription factor P37238 19016 6 E3|6 53.41 cM mouse K293-ub 1877844703 GEDKIKFkHITPLQE protein degradation; ubiquitination cell differentiation, inhibited 31653699 1 1 0 -TOPORS TOPORS Cell cycle regulation; EC 6.3.2.-; EC 6.3.2.19; Ligase; SUMO LIGASE; SUMO conjugating system; SUMO ligase; UBIQUITIN LIGASE; Ubiquitin conjugating system; Ubiquitin ligase Q9NS56 10210 9p21.1 human S98-p 453973 QTVPADAsPDSKCPI protein degradation; molecular association, regulation; ubiquitination; enzymatic activity, altered; enzymatic activity, induced UBE2D1(INDUCES) 19053840; 26872363 2 49 1 regulation of E3 ligase activities of TOPORS; regulates the ubiquitin, but not the SUMO ligase activity of TOPORS -AURKB AurB EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, Other; Protein kinase, Ser/Thr (non-receptor) Q96GD4 9212 17p13.1 human S331-p 22259700 HPWVRANsRRVLPPS molecular association, regulation; intracellular localization; enzymatic activity, induced cell cycle regulation; chromatin organization, altered; cytoskeletal reorganization Survivin(INDUCES) 22024163; 24344188; 24798733; 33355621 5 0 0 -Etv1 ETV1 DNA-binding; Oncoprotein; Transcription factor P41164 14009 12 A3|12 17.99 cM mouse S191-p 3059602 HRFRRQLsEPCNSFP ETS_PEA3_N activity, inhibited transcription, altered 10982847 3 0 3 in Mv1Lu cells (mutation shows no effect in HeLa cells) -MSN Moesin Cytoskeletal; Motility/polarity/chemotaxis P26038 4478 Xq12 human T66-p 18911798 LKLNKKVtAQDVRKE FERM_N intracellular localization carcinogenesis, induced; cell motility, induced; cell growth, induced; cell adhesion, inhibited 24755472 1 2 0 cell spreading inhibited, moesin distribution regulation, increased cell migration and cell invasion and metastasis -Zdhhc5 ZDHHC5 EC 2.3.1.225; Membrane protein, integral; Membrane protein, multi-pass; Transferase Q8VDZ4 228136 2|2 D mouse Y91-p 462809 DDFRAPLyKTVEIKG receptor internalization, induced; enzymatic activity, inhibited; phosphorylation; palmitoylation endocytosis, induced 32958780 1 5 88 inhibits palmitoylation of CD36 further inducing phosphorylation of SYK and then VAV and JNK -CAMK4 CAMK4 EC 2.7.11.17; KINASE; Kinase, protein; Protein kinase, CAMK; Protein kinase, Ser/Thr (non-receptor) Q16566 814 5q22.1 human S58-gl 7780003 ELGRGATsIVYRCKQ Pkinase phosphorylation 19506079 1 1 0 reduce phosphorylation at CAMK4-T200 -NUP98 NUP98 iso2 Motility/polarity/chemotaxis; Nucleoporin P52948-2 4928 11p15.4 human S636-p 4740143 QQDGDEDsLVSHFYT intracellular localization 21335236 1 18 2 as multiple sites (13PM) mutant -Pdgfrb PDGFRB EC 2.7.10.1; KINASE; Kinase, protein; Membrane protein, integral; Oncoprotein; Protein kinase, TK; Protein kinase, tyrosine (receptor) P05622 18596 18 E1|18 34.41 cM mouse Y1020-p 447523 PNESDNDyIIPLPDP phosphorylation 11940581 21 0 0 tyrosine phosphorylation of Gab1 -RPA2 RFA2 DNA replication P15927 6118 1p35.3 human S29-p 448338 QSPGGFGsPAPSQAE molecular association, regulation; intracellular localization cell cycle regulation; DNA repair, induced; transcription, altered p53(INDUCES); WRN(INDUCES) 17928296; 19671522; 20154705; 21107010; 21664290; 26237679; 29875999 11 5 0 -DUSP1 DUSP1 EC 3.1.3.16; EC 3.1.3.48; Motility/polarity/chemotaxis; PHOSPHATASE; Protein phosphatase, dual-specificity P28562 1843 5q35.1 human S334-p 53736000 AVLDRGTsTTTVFNF protein degradation; ubiquitination; phosphorylation signaling pathway regulation 25799226 1 0 0 induces phosphorylation of IRS-1 subsequently inhibiting phosphorylation of AKT, regulates P38-Jnk pathway -THRA TR-alpha DNA-binding; Nuclear receptor; Transcription factor NP_990644 396251 chicken K128-ac 10769107 DLVLDDSkRVAKRKL molecular association, regulation carcinogenesis, inhibited; transcription, altered SMRT(DISRUPTS); ACTR1A(INDUCES) DNA(INDUCES) 19819978 1 0 0 induces transactivation and transrepression of transcription -Tnp2 TP2 DNA-binding P11101 24840 10q11 rat K105-ac 10769112 RKRTHRAkRRSSGRR TP2 molecular association, regulation chromatin organization, altered NPM3(DISRUPTS) 19710011 1 1 0 -POU4F1 POU4F1 Cell development/differentiation; DNA-binding; Transcription factor Q01851 5457 13q31.1 human T39-p 6311909 IRRACLPtPPLQSNL activity, induced cell differentiation, altered; transcription, induced 19135033 1 0 0 activation of galanin promoter induced by retinoic acid -CTTN Cortactin Actin-binding; Cytoskeletal; Motility/polarity/chemotaxis Q14247 2017 11q13.3 human K272-ac 461722 YKTGFGGkFGVQSER HS1_rep molecular association, regulation; intracellular localization cell motility, inhibited ACTB(DISRUPTS) 17643370 1 3 18 Acetylation prevents localization to membrane ruf?es. -SKIL SKIL Cell development/differentiation; Transcription, coactivator/corepressor P12757 6498 3q26.2 human K446-ub 3144804 EKAHSSGkLQKTVSY protein degradation signaling pathway regulation 11691834 1 0 0 TGF-beta signaling -LRRK2 LRRK2 EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, Ser/Thr (non-receptor); Protein kinase, TKL Q5S007 120892 12q12 human S1292-p 13204416 PNEMGKLsKIWDLPL LRR_4 intracellular localization; enzymatic activity, induced cell growth, induced 23241745; 29212815 15 3 0 -RALB RALB G protein; G protein, monomeric; G protein, monomeric, Ras P11234 5899 2q14.2 human K47-ub 40190212 VEDYEPTkADSYRKK Ras molecular association, regulation autophagy, induced; signaling pathway regulation Sec5(INDUCES); EXOC8(DISRUPTS) 24056301 1 1 0 promotes TBK1-IRF3 signaling -WWTR1 TAZ Oncoprotein; Transcription, coactivator/corepressor Q9GZV5 25937 3q25.1 human Y305-p 1876136800 PFLNGGPyHSREQST intracellular localization carcinogenesis, induced; cell growth, induced; apoptosis, inhibited; transcription, induced 35041461 1 1 0 -MIP AQP0 Channel, misc.; Membrane protein, integral; Membrane protein, multi-pass; Transporter, aquaporin family P30301 4284 12q13.3 human S229-p 453400 LLFPRLKsISERLSV molecular association, regulation; protein conformation Calmodulin(DISRUPTS) 27660387 3 3 0 phosphorylation of AQP0 disrupts calcium sensitivity by altering the AQP0-CaM interaction interface -CASP9 CASP9 Apoptosis; EC 3.4.22.62; Protease P55211 842 1p36.21 human Y153-p 455198 RGNADLAyILSMEPC activity, induced; molecular association, regulation; enzymatic activity, inhibited apoptosis, induced p53(INDUCES) 15657060; 29066624 2 1 0 -RAP1GAP RAP1GAP GAP; GAP, Ras; Motility/polarity/chemotaxis P47736 5909 1p36.12 human S499-p 3190708 PFGSRRSsAIGIENI activity, induced 19218462 4 25 25 increased Rap1 activity -Cit CRIK EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, AGC; Protein kinase, Ser/Thr (non-receptor) P49025 12704 5|5 F mouse Y1237-p 477284 TERSDLEyQLENIQV molecular association, regulation cell cycle regulation RHOA(INDUCES) 27551053 1 3 1 prevents the completion of cytokinesis -Slc6a3 DAT Membrane protein, integral; Membrane protein, multi-pass; Transporter; Transporter, SLC family P23977 24898 1p11 rat T53-p 6843600 TLINPPQtPVEAQER activity, induced 22722938 5 2 0 dopamine transporter activity -BORA BORA Activator Q6PGQ7 79866 13q21.33 human S325-p 4753166 SPYIDGCsPIKNWSP molecular association, regulation DNA repair, inhibited MDC1(INDUCES) 25742493 1 17 3 -Gja1 GJA1 Channel, misc.; Membrane protein, integral; Membrane protein, multi-pass; Motility/polarity/chemotaxis P08050 24392 20q11 rat S257-p 465456 TTGPLSPsKDCGSPK activity, inhibited 16000550 2 8 0 MAPK1 mediated phosphorylatiion of Cx43 inducing inhibition of myometrial gap junctions. -HAVCR2 TIM-3 Membrane protein, integral; Receptor, misc. Q8TDQ0 84868 5q33.3 human Y272-p 26371002 YTIEENVyEVEEPNE receptor inactivation, induced; molecular association, regulation; intracellular localization signaling pathway regulation; transcription, inhibited STAT1(INDUCES); Fyn(INDUCES); P38A(INDUCES); PIK3R1(INDUCES) 26492563; 27757304; 31848194 4 0 0 suppresses TCR-mediated activation of the NF-kB/NFAT reporter activity; PI3K-Akt-mTOR pathway for NK cells in liver; Galectin-9 increased the binding between Tim-3- and STAT1, nuclear localization of STAT1 is linhibited, enhanced SOCS1 expression -GATA1 GATA1 DNA-binding; Transcription factor P15976 2623 Xp11.23 human K314-ac 459194 RKASGKGkKKRGSSL molecular association, regulation transcription, altered DNA(INDUCES) 16888089 3 1 0 -TTK TTK Cancer Testis Antigen (CTA); EC 2.7.12.1; KINASE; Kinase, protein; Protein kinase, Other; Protein kinase, dual-specificity (non-receptor) P33981 7272 6q14.1 human S321-p 3189826 SKPSGNDsCELRNLK intracellular localization; enzymatic activity, induced cell cycle regulation 25265012; 26119734 2 10 0 regulates spindle assembly checkpoint and recruitment of SAC proteins; autophosphorylation of this site is required for release TTK from kinetochore; causes decreased kinetochore localization of BubR1 and Mad2. -RIPK1 RIPK1 EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, Ser/Thr (non-receptor); Protein kinase, TKL Q13546 8737 6p25.2 human K604-ub 2188100 HWKNCARkLGFTQSQ Death protein degradation 35711363 3 2 0 degradation and inhibited necroptosis -Capn2 CAPN2 EC 3.4.22.53; Motility/polarity/chemotaxis; Protease O08529 12334 1|1 H5 mouse S50-p 451162 GALFQDPsFPALPSS Peptidase_C2 intracellular localization 16809781 3 1 0 -Zdhhc3 ZDHHC3 EC 2.3.1.225; Membrane protein, integral; Membrane protein, multi-pass; Transferase Q8R173 69035 9|9 F4 mouse Y297-p 56580000 GKADPYQyVV_____ enzymatic activity, inhibited cytoskeletal reorganization 27247265 1 0 0 neurite outgrowth; palmitoylation -EGFR EGFR EC 2.7.10.1; KINASE; Kinase, protein; Membrane protein, integral; Oncoprotein; Protein kinase, TK; Protein kinase, tyrosine (receptor) P00533 1956 7p11.2 human K846-ub 1065313 AARNVLVkTPQHVKI PK_Tyr_Ser-Thr protein degradation 17940017 1 3 0 -CERS2 LASS2 DNA-binding; Membrane protein, integral; Membrane protein, multi-pass; Transferase Q96G23 29956 1q21.3 human S349-p 469771 DREETESsEGEEAAA enzymatic activity, induced 26887952 1 43 198 -RBBP8 CtIP EC 3.1.-.-; Transcription, coactivator/corepressor Q99708 5932 18q11.2 human K578-sm 55429361 NKPSLQIkEENAVFK molecular association, regulation; ubiquitination DNA repair, induced RNF4(INDUCES) 33406258; 33723063 2 1 0 protects stalled replication forks from over-resection; colocalizes with RFA2; promotes DNA end resection, and substituting K578 with arginine results in impaired end resection and HR activity -Pdx1 PDX1 DNA-binding; Transcription factor P52947 29535 12p11 rat S268-p 11279404 LPSGLSAsPQPSSIA protein degradation 19833727 3 4 0 -Aire AIRE Transcription factor Q9Z0E3 11634 10 C1|10 39.72 cM mouse T69-p 1191300 ALLSWLLtRDSGAIL HSR molecular association, regulation transcription, induced CDK9(INDUCES); CBP(INDUCES); BRD4(INDUCES) 26216992 3 1 0 recruits Brd4 -EPOR EPOR Membrane protein, integral; Receptor, cytokine P19235 2057 19p13.2 human Y485-p 3103701 GGLSDGPySNPYENS apoptosis, inhibited 14662339 3 0 0 -RIPK1 RIPK1 EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, Ser/Thr (non-receptor); Protein kinase, TKL Q13546 8737 6p25.2 human S25-p 27116402 LESAELDsGGFGKVS PK_Tyr_Ser-Thr molecular association, regulation; enzymatic activity, inhibited; phosphorylation apoptosis, inhibited FADD(INDUCES); CASP8(INDUCES) 34862394 3 4 0 inhibits autophosphorylation at S166 -ATM ATM DNA repair, damage; EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, Ser/Thr (non-receptor); Protein kinase, atypical; Tumor suppressor Q13315 472 11q22.3 human S1270-p 1881548600 SHFDEVKsIANQIQE protein degradation; ubiquitination carcinogenesis, induced; cell growth, induced; apoptosis, inhibited; DNA repair, inhibited; transcription, altered 37075701 1 1 0 -DAB1 DAB1 Adaptor/scaffold O75553 1600 1p32.2-p32.1 human Y232-p 447961 SQKKEGVyDVPKSQP molecular association, regulation CRK(INDUCES) 15316068 13 5 12 -PIK3R1 PIK3R1 KINASE; Kinase, lipid; Motility/polarity/chemotaxis P23727 282307 cow S83-p 471075 YIGRKKIsPPTPKPR molecular association, regulation; phosphorylation; enzymatic activity, induced cell cycle regulation; apoptosis, induced; apoptosis, inhibited HRas(INDUCES); PKAR2B(INDUCES); ER-alpha(INDUCES) 17016431; 17043656 3 1 1 Phosphorylation affects survival in thyroid stimulating hormone or cAMP (S83A = reduced survival, S83D = reduced apoptosis). S83A mutant slows S-G2/M progression, and reduces AKT phosphorylation. Enzymatic activation in TSH (not via EGF); cAMP-induced protection from apoptosis was less efficient in S83A and more efficient in S83D. S83A mutants do not arrest in G1 in presence of cAMP where as S83D accumulate in G1 (even in absence of cAMP). cAMP-stimulated phosphorylation of this site leads to Akt1 and GSK3a activation, and binding to p21Ras and estrogen receptor. -ELMO2 ELMO2 Cytoskeletal; Motility/polarity/chemotaxis Q96JJ3 63916 20q13.12 human Y713-p 477009 IPKEPSSyDFVYHYG carcinogenesis, induced; cell motility, induced 25332238 2 3 16 -RACK1 RACK1 Adaptor/scaffold; G protein; G protein, heterotrimeric; G protein, heterotrimeric beta; Motility/polarity/chemotaxis; Nuclear receptor co-regulator P63244 10399 5q35.3 human S122-ga 1883988600 SDNRQIVsGSRDKTI protein stabilization 36658304 1 0 0 circVPRBP dramatically reduces the S122 O-GlcNAcylation by blocking site to promote RACK1 degradation -ICAM1 ICAM1 Cell adhesion; Immunoglobulin superfamily; Membrane protein, integral P05362 3383 19p13.2 human Y501-p 450969 GTAGLSTyLYNRQRK TM protein processing 14973144 1 0 0 proteolytic cleavage -RASGRP1 RASGRP1 GEF; GEF, Ras O95267 10125 15q14 human T184-p 456226 RDWSRKLtQRIKSNT signaling pathway regulation 15899849 3 0 0 -Grin2a NMDAR2A Channel, ligand-gated; Membrane protein, integral; Membrane protein, multi-pass Q00959 24409 10q11 rat S1232-p 448260 SGHFTMRsPFKCDAC NMDAR2_C activity, induced; intracellular localization neural plasticity 11675505; 22870316; 24769228 6 1 7 -NINL Nlp Cell cycle regulation; Microtubule-binding Q9Y2I6 22981 20p11.21 human S585-p 15668108 RLPKNRHsPSWSPDG intracellular localization cell cycle regulation 20864540 1 1 0 -GRB7 GRB7 Adaptor/scaffold; Motility/polarity/chemotaxis Q14451 2886 17q12 human S194-p 58912301 KYELFKSsPHSLFPE protein degradation; molecular association, regulation; ubiquitination cell cycle regulation PIN1(INDUCES) 27658202 1 0 0 -CASP8 CASP8 Apoptosis; EC 3.4.22.61; Protease Q14790 841 2q33.1 human S347-p 450983 FTGLKCPsLAGKPKV Peptidase_C14 activity, inhibited apoptosis, inhibited 14970175 1 0 0 -ADRA1D ADRA1D GPCR, family 1; Membrane protein, integral; Membrane protein, multi-pass; Receptor, GPCR P25100 146 20p13 human S334-p 1424270003 HTFRSSLsVRLLKFS 7tm_1 receptor internalization, altered signaling pathway regulation 29551601 1 1 0 regulates ERK signaling pathway, induces calcium signaling de-sensitization -Epor EPOR Membrane protein, integral; Receptor, cytokine P14753 13857 9 A3|9 7.93 cM mouse Y503-p 449885 SEPLHPGyVACS___ molecular association, regulation; receptor internalization, altered apoptosis, altered; signaling pathway regulation PLCG1(INDUCES); PIK3R2(INDUCES); PIK3R1(INDUCES) 15953601; 16380376; 19336760; 21255641 9 0 0 activates PI3K/Akt pathway in signaling by myeloproliferative disorder-associated Jak2 V617 mutant -MRE11 MRE11A Cell cycle regulation; DNA repair, damage; DNA-binding; Deoxyribonuclease P49959 4361 11q21 human S590-p 11506401 NSASRGGsQRGRADT molecular association, regulation DNA(DISRUPTS) 19709933 1 0 0 -MAP2K4 MKK4 EC 2.7.12.2; KINASE; Kinase, protein; Protein kinase, STE; Protein kinase, dual-specificity (non-receptor) P45985 6416 17p12 human Y307-p 1881548608 LATGRFPyPKWNSVF enzymatic activity, inhibited carcinogenesis, inhibited; apoptosis, induced; transcription, inhibited 37020040 1 1 0 -GADD45GIP1 GADD45GIP1 Cell cycle regulation; Nuclear receptor co-regulator Q8TAE8 90480 19p13.13 human S221-p 474542 PAASGAPsS______ cell growth, altered 17069992 1 0 0 promotes cell proliferation -Junb JunB Motility/polarity/chemotaxis; Oncoprotein; Transcription factor P09450 16477 8 C3|8 41.41 cM mouse K237-sm 3144820 SRGASAFkEEPQTVP Jun intracellular localization transcription, induced 18424718 1 2 0 -FPR1 FPR1 GPCR, family 1; Membrane protein, integral; Membrane protein, multi-pass; Motility/polarity/chemotaxis; Receptor, GPCR P21462 2357 19q13.41 human T329-p 450665 RALTEDStQTSDTAT receptor desensitization, altered; receptor internalization, altered 10514456 2 1 0 -SDCBP syntenin Adaptor/scaffold; Cell adhesion; Cytokine; Membrane protein, integral; Motility/polarity/chemotaxis; Vesicle O00560 6386 8q12.1 human Y46-p 455029 IPHDGNLyPRLYPEL endocytosis, induced; exocytosis, induced 29109268; 33732417 2 16 490 -KDM1A LSD1 DEMETHYLASE; Demethylase; EC 1.-.-.-; Nuclear receptor co-regulator; Oxidoreductase; Transcription factor O60341 23028 1p36.12 human K114-m2 53529105 GRRTSRRkRAKVEYR molecular association, regulation; intracellular localization CHD-1(INDUCES) DNA(INDUCES) 26751641 1 1 0 -PKP1 plakophilin 1 Cell adhesion; Motility/polarity/chemotaxis Q13835 5317 1q32.1 human S191-p 15405309 YSFYSTCsGQKAIKK activity, induced; protein stabilization cell motility, induced; cell growth, induced; translation, induced; cell adhesion, inhibited 23444369 1 2 17 -CYLD CYLD DEUBIQUITINASE; EC 3.4.19.12; Protease; Tumor suppressor; Ubiquitin conjugating system; Ubiquitin-specific protease Q9NQC7 1540 16q12.1 human S439-p 12173911 SIGHSPLsLSAQSVM CYLD_phos_site ubiquitination 15870263 2 1 0 induces ubiquitination of TRAF2 -HNRNPK hnRNP K RNA splicing; RNA-binding; Spliceosome P61978 3190 9q21.32 human S116-p 452369 EEGLQLPsPTATSQL protein degradation; intracellular localization cell growth, induced; transcription, induced 20960454; 24236111; 28423622 4 38 22 localized to nuclear matrix -Ntrk1 TrkA EC 2.7.10.1; KINASE; Kinase, protein; Membrane protein, integral; Oncoprotein; Protein kinase, TK; Protein kinase, tyrosine (receptor) P35739 59109 2q34 rat Y499-p 447762 HIMENPQyFSDTCVH molecular association, regulation; enzymatic activity, induced cell differentiation, altered; cell growth, altered SHC3(INDUCES); SHC2(INDUCES) 11238898; 12006576; 8156997 23 0 2 -LY6G6F G6f Cell surface; Membrane protein, integral Q5SQ64 259215 6p21.33 human Y281-p 450289 FKPEIQVyENIHLAR molecular association, regulation; phosphorylation GRB2(INDUCES); GRB7(INDUCES) 12852788; 16941570 3 2 8 -PAQR3 PAQR3 Membrane protein, integral; Membrane protein, multi-pass; Receptor, misc. Q6TCH7 152559 4q21.21 human T32-p 53998800 PRGIRLYtYEQIPGS intracellular localization; phosphorylation autophagy, induced 26834238 1 0 0 punctiform distribution of PAQR3 upon glucose starvation, ; PAQR3 T32- affects Beclin1 S93 phosphorylation -CDKN1A p21Cip1 Cell cycle regulation; Inhibitor P38936 1026 6p21.2 human K141-ub 9897002 PGDSQGRkRRQTSMT protein degradation; ubiquitination 13678583; 17429006 4 0 0 under chelated Fe2+ conditions p21Cip1 is degraded by ubiquitin independent proteasomal degradation.; UV-induced -PIK3CG PIK3CG Autophagy; Carbohydrate Metabolism - inositol phosphate; EC 2.7.1.153; EC 2.7.11.1; KINASE; Kinase, lipid; Motility/polarity/chemotaxis; Protein kinase, Ser/Thr (non-receptor) P48736 5294 7q22.3 human S582-p 28702402 LWHFRYEsLKHPKAY PI3Ka molecular association, regulation; enzymatic activity, induced signaling pathway regulation PIK3R6(DISRUPTS) 23824069 1 1 0 GPCR-mediated p110gamma signaling; disrupts immune cell responses activated by G protein-coupled receptors (GPCRs) -GRB10 GRB10 Adaptor/scaffold Q13322 2887 7p12.1 human S104-p 483656 RSIQPQVsPRQRVQR protein stabilization 21659604 1 22 1 -BAP1 BAP1 DEUBIQUITINASE; EC 3.4.19.12; Protease; Tumor suppressor; Ubiquitin conjugating system; Ubiquitin-specific protease Q92560 8314 3p21.1 human S276-p 31012814 ELIQTHKsQESQLPE intracellular localization DNA repair, induced 24347639 1 3 0 -PHF20 PHF20 ACETYLTRANSFERASE; Acetyltransferase; C2H2-type zinc finger protein; DNA-binding; Nuclear envelope Q9BVI0 51230 20q11.22-q11.23 human S291-p 23303200 ELRRRKIsKGCEVPL protein degradation; molecular association, regulation; intracellular localization cell cycle regulation; carcinogenesis, induced; cell growth, induced; apoptosis, inhibited; transcription, inhibited DNA(DISRUPTS) 22334668; 22975685 2 0 0 induces degradation of p53 -Map3k12 DLK EC 2.7.11.25; KINASE; Kinase, protein; Protein kinase, Ser/Thr (non-receptor); Protein kinase, TKL Q60700 26404 15|15 F3 mouse S302-p 4727859 SDKSTKMsFAGTVAW PK_Tyr_Ser-Thr protein stabilization 23979718 1 1 2 -Tub tubby Lipid-binding; Membrane protein, peripheral P50586 22141 7 E3|7 57.21 cM mouse Y464-p 34823401 IHGNDPDyIVMQFGR Tub intracellular localization 25031889 1 0 0 translocation to the nucleus -Atf1 ATF-1 Transcription factor P81269 11908 15|15 F1 mouse S63-p 449762 GILARRPsYRKILKD pKID molecular association, regulation; acetylation cell growth, inhibited DNA(DISRUPTS) 25312646 20 2 29 HSF1 acetylation, Decreased cell survival, disrupts HSF1 binding to HSP70 promoter -SPAG5 SPAG5 Cell cycle regulation Q96R06 10615 17q11.2 human S974-p 1261100 EESLAEMsIMTTELQ intracellular localization 18055457 1 0 0 required for SPAG5 localization to the spindle apparatus during mitosis -CDC25C CDC25C EC 3.1.3.48; Motility/polarity/chemotaxis; PHOSPHATASE; Protein phosphatase, dual-specificity P30307 995 5q31.2 human S168-p 449022 SEMKYLGsPITTVPK enzymatic activity, inhibited cell cycle regulation; cell adhesion, altered 20220133; 8119945 4 15 59 -NPM1 NPM1 Nucleolus; Oncoprotein; RNA-binding; Translation P06748 4869 5q35.1 human S125-p 459897 AVEEDAEsEDEEEED molecular association, regulation; intracellular localization; phosphorylation cell cycle regulation; carcinogenesis, induced; cell motility, induced; cell growth, induced; apoptosis, inhibited; transcription, induced; signaling pathway regulation Other(INDUCES) 24857377; 30453269; 32606971; 36563749 11 95 558 induces binding to HIV1 TAT ; induces ERK phosphorylation and NFKB translocation thus inducing ERK/NF-K? signaling -SCD SCD EC 1.14.19.1; Endoplasmic reticulum; Lipid Metabolism - unsaturated fatty acid biosynthesis; Membrane protein, integral; Membrane protein, multi-pass; Oxidoreductase O00767 6319 10q24.31 human Y55-p 3411245 PDIKDDIyDPTYKDK protein stabilization cell cycle regulation; cell growth, induced; apoptosis, induced 28724430 1 2 6 -ZNF281 ZNF281 C2H2-type zinc finger protein; DNA-binding; Transcription factor Q9Y2X9 23528 1q32.1 human S785-p 472466 SSAFQSSsQKLTSQK intracellular localization DNA repair, induced 31570788 1 3 1 -Hcn2 HCN2 Channel, cation; Membrane protein, integral; Membrane protein, multi-pass O88703 15166 10|10 C1 mouse S861-p 1871246002 SARSRLSsNL_____ activity, induced 33240105 1 0 0 Induced HCN2 current -N Nucleocapsid Protein P59595 1489678 SARSCoV1 S189-p 1868301201 QASSRSSsRSRGNSR CoV_nucleocap molecular association, regulation Nucleocapsid Protein(INDUCES) 23717688 3 3 0 di-domain self-association -Cdh1 CDH1 Cell adhesion; Membrane protein, integral; Motility/polarity/chemotaxis; UBIQUITIN LIGASE; Ubiquitin ligase P09803 12550 8 D3|8 53.18 cM mouse S846-p 478354 GSGSEAAsLSSLNSS CADH_Y-type_LIR intracellular localization 24063632 4 0 0 internalization of E-cadherin off the cell surface -Rps6kb1 p70S6K EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, AGC; Protein kinase, Ser/Thr (non-receptor); Translation Q8BSK8 72508 11|11 C mouse S489-gl 1869633703 EQMDVTVsGEASAPL phosphorylation signaling pathway regulation 32601203 1 0 0 supresses mTORC1/S6K1 signaling and p70S6K phosphorylation at S418 and T229, regulates macrophage pro-inflammatory signaling, -Oprm1 MOR-1 GPCR, family 1; Membrane protein, integral; Membrane protein, multi-pass; Receptor, GPCR P42866 18390 10 A1|10 1.85 cM mouse S363-p 447783 STIEQQNsARIRQNT receptor recycling, induced 25801029; 31575621 11 6 0 -YBX1 YB-1 RNA processing; RNA splicing; RNA-binding; Transcription factor P67809 4904 1p34.2 human S174-p 469055 SGEKNEGsESAPEGQ transcription, altered 31387591 2 67 31 downregulation of synaptopodin, nephrin and podocin expression -FOXO4 FOXO4 DNA-binding; Oncoprotein; Transcription factor P98177 4303 Xq13.1 human K407-ac 459044 GGLPSSSkLATGVGL activity, inhibited transcription, inhibited 12964026 2 0 0 -Runx2 AML3 iso5 DNA-binding; Transcription factor Q08775-5 12393 17 B3|17 21.33 cM mouse K202-ub 1873375610 VGRSGRGkSFTLTIT Runt cell differentiation, induced; transcription, induced 28500134 1 0 0 -Pcna PCNA Cell cycle regulation; DNA replication P17918 18538 2 F2|2 64.15 cM mouse Y211-p 471414 HLTFALRyLNFFTKA PCNA_C enzymatic activity, induced; phosphorylation carcinogenesis, induced; cell motility, induced; transcription, altered; signaling pathway regulation; cell growth, induced; apoptosis, inhibited; DNA repair, inhibited; transcription, inhibited 34433039; 35628489 7 2 2 induces ALDH activity; inhibits H2AX, TBK1, IRF3 and ATM phosphorylation, regulates cGAS-TBK1-IRF3 pathway -GMPR GMPR EC 1.7.1.7; Nucleotide Metabolism - purine; Oxidoreductase P36959 2766 6p22.3 human Y267-p 1005248 GRKLKLFyGMSSDTA IMPDH molecular association, regulation; enzymatic activity, induced carcinogenesis, inhibited RAC1(INDUCES) 35148834 1 2 0 -E2F1 E2F1 DNA-binding; Transcription factor Q01094 1869 20q11.22 human T433-p 447871 DCDFGDLtPLDF___ protein degradation; ubiquitination; intracellular localization cell differentiation, altered; autophagy, inhibited; signaling pathway regulation 10428966; 18794805; 27903963; 33174204 5 0 0 E2F1-autophagy-E2F7a pathway -UMPS UMPS EC 2.4.2.10; EC 4.1.1.23; Lyase; Nucleotide Metabolism - pyrimidine; Transferase; Xenobiotic Metabolism - drug metabolism - other enzymes P11172 7372 3q21.2 human S214-p 3180453 VAANHNGsPLSIKEA enzymatic activity, inhibited 37291265 1 15 1 -Jam2 JAM2 Cell adhesion; Membrane protein, integral Q9JI59 67374 16|16 C3.3 mouse S280-p 11263901 FQKGSPAsKVTTMSE intracellular localization 12953056 1 0 0 S280A mutant localized at cell-cell contacts -KDM3A JMJD1A DEMETHYLASE; Demethylase; EC 1.14.11.-; Nuclear receptor co-regulator; Oxidoreductase Q9Y4C1 55818 2p11.2 human S265-p 453894 GAVKRKSsENNGTLV molecular association, regulation cell cycle regulation; RNA splicing, induced; transcription, induced ARID1A(INDUCES); PPAR-gamma(INDUCES); PRDM16(INDUCES) 25948511; 29674659; 34321328 3 4 1 -Srgap3 ARHGAP14 GAP; GAP, Rac/Rho Q812A2 259302 6|6 E3 mouse S858-p 3175109 MGRVRLRsDGAAIPR enzymatic activity, induced cell motility, altered 26499801 1 20 24 S858A enhanced cell migration -MAP3K3 MEKK3 EC 2.7.11.25; KINASE; Kinase, protein; Protein kinase, STE; Protein kinase, Ser/Thr (non-receptor) Q99759 4215 17q23.3 human T294-p 2243102 DYSDGRRtFPRIRRH molecular association, regulation 14-3-3 beta(INDUCES) 18308725 1 4 1 facilitated by phosphorylation of S526 -MEF2B MEF2B iso2 DNA-binding; Transcription factor Q02080-2 100271849 19p13.11 human S324-p 29649500 SIKSERLsPAPGGPG sumoylation transcription, inhibited 23974956 1 2 0 Phosphorylation-dependent sumoylation inhibited transcription. ; increases sumoylation at MEF2B iso2-K319 -TTK TTK Cancer Testis Antigen (CTA); EC 2.7.12.1; KINASE; Kinase, protein; Protein kinase, Other; Protein kinase, dual-specificity (non-receptor) P33981 7272 6q14.1 human S333-p 41389702 NLKSVQNsHFKEPLV intracellular localization; enzymatic activity, induced 26119734 1 1 0 regulates spindle assembly checkpoint and recruitment of SAC proteins -GUCA1B GCAP2 Calcium-binding Q9UMX6 2979 6p21.1 human S197-p 455322 LAQQRRKsAMF____ intracellular localization 29440717 3 0 0 phosphomimetic S201 is suffcient to retain GCAP2 at inner rod segments -MISP MISP Unknown function Q8IVT2 126353 19p13.3 human S394-p 457010 PGLRRALsSDSILSP AKAP2_C cytoskeletal reorganization 34023777 1 35 101 -CYCS CYCS Apoptosis; Mitochondrial; Oxidoreductase; PHOSPHATASE; Protein phosphatase, Ser/Thr (non-receptor) P00004 100053958 horse K88-ac 1968623 MIFAGIKkKTEREDL Cytochrom_C enzymatic activity, induced 19645667 1 2 0 -Spi1 PU.1 DNA-binding; Oncoprotein; Transcription factor Q6BDS1 rat S147-p 455900 QSPPLEVsDGEADGL molecular association, regulation IRF8(INDUCES) 15688197 6 4 0 -AJUBA JUB Cell adhesion; Motility/polarity/chemotaxis; Transcription, coactivator/corepressor Q96IF1 84962 14q11.2 human S119-p 483805 EPTAPALsPRSSFAS cell cycle regulation; cell growth, induced 27226586 1 28 0 mitotic phosphorylation promotse cell proliferation and anchorage-independent growth -RPE65 RPE65 Cofactor and Vitamin Metabolism - retinol; EC 3.1.1.64 Q16518 6121 1p31.3 human C112-pa 12559508 TCAFPDPcKNIFSRF RPE65 intracellular localization; enzymatic activity, induced 19049981 1 1 0 membrane localization -Pecam1 PECAM-1 Cell adhesion; Cell development/differentiation; Membrane protein, integral; Motility/polarity/chemotaxis Q08481 18613 11|11 E1 mouse Y702-p 448760 TRATETVySEIRKVD molecular association, regulation cell adhesion, altered SHP-2(INDUCES); SHP-1(INDUCES) 9298995; 9624175 14 20 786 Y702 A.K.A. Y686; induces switch from heterophilic to homophilic cell-cell aggregation -JUN Jun Oncoprotein; Transcription factor P05412 3725 1p32.1 human T231-p 455366 ALKEEPQtVPEMPGE Jun molecular association, regulation; activity, inhibited transcription, altered SP1(DISRUPTS) 1516134; 17215518 3 0 0 -Trim28 TIF1B EC 6.3.2.-; KINASE; Kinase, protein; Ligase; Nuclear receptor co-regulator; Protein kinase, atypical; SUMO LIGASE; SUMO ligase; Transcription, coactivator/corepressor; UBIQUITIN LIGASE; Ubiquitin conjugating system; Ubiquitin ligase Q62318 21849 7|7 A1 mouse K676-sm 3142607 CHVLPDLkEEDGSLS transcription, inhibited 17298944 2 2 0 -SCML2 SCML2 Transcription factor Q9UQR0 10389 Xp22.13 human T305-p 3216633 SSSVKNItPRKKGPN RBR cell cycle regulation 24358021 1 3 10 -STAT2 STAT2 DNA-binding; Transcription factor P52630 6773 12q13.3 human Y690-p 448193 NLQERRKyLKHRLIV intracellular localization transcription, induced 15767445; 36148221 19 0 0 -Arhgdia RhoGDI alpha Apoptosis; Cell adhesion; Cell development/differentiation; G protein regulator, misc.; Motility/polarity/chemotaxis Q5XI73 360678 10q32.3 rat S101-p 452195 LESFKKQsFVLKEGV Rho_GDI molecular association, regulation cell growth, altered RAC1(DISRUPTS); CDC42 iso1(DISRUPTS) 19103160 6 11 1 in response to bFGF stimulation -PHGDH PHGDH Amino Acid Metabolism - glycine, serine and threonine; Cell development/differentiation; EC 1.1.1.95; Oxidoreductase O43175 26227 1p12 human T57-p 4730705 GLIVRSAtKVTADVI 2-Hacid_dh carcinogenesis, induced; cell growth, induced; apoptosis, inhibited 23374352 1 3 0 -MAPKAP1 Sin1 Adaptor/scaffold Q9BPZ7 79109 9q33.3 human S186-p 27458520 VYLPLHSsQDRLLPM CRIM molecular association, regulation; phosphorylation apoptosis, inhibited ECT2(INDUCES) 34982576 1 6 0 induces AKT phosphorylation -Dok2 DOK2 Adaptor/scaffold O70469 13449 14 D2|14 36.71 cM mouse Y276-p 452174 LPRPESPySRPHDSL molecular association, regulation cell differentiation, altered; cell growth, altered RASA1(INDUCES) 10428862; 10508618; 12093790 3 0 1 -MAFA MAFA DNA-binding; Oncoprotein; Transcription factor; Tumor suppressor Q8NHW3 389692 8q24.3 human T57-p 456028 LSSTPLStPCSSVPS activity, induced; protein degradation; molecular association, regulation; ubiquitination carcinogenesis, induced; transcription, induced; signaling pathway regulation PCAF(INDUCES) 18042454; 19407223; 23660596; 35406570 8 1 0 Ubiquitin proteosomal pathway -WAS WASP Adaptor/scaffold; Motility/polarity/chemotaxis P42768 7454 Xp11.23 human K147-sm 52504000 LVQEKIQkRNQRQSG molecular association, regulation; acetylation transcription, altered; signaling pathway regulation COMMD1(DISRUPTS); HDAC6(DISRUPTS) 26261240 1 0 0 induces hypoacetylation at H3K14, regulates NF-kB signaling -Arrb2 ARRB2 Adaptor/scaffold Q91YI4 216869 11 B3|11 42.99 cM mouse K171-ub 573763286 SVRLIIRkVQFAPET Arrestin_N protein degradation 33243993 1 1 0 -Kalrn kalirin EC 2.7.11.1; GEF; GEF, Rac/Rho; KINASE; Kinase, protein; Protein kinase, CAMK; Protein kinase, Ser/Thr (non-receptor) P97924 84009 11q22 rat T77-p 1315601 DVCKRGFtVIIDMRG CRAL_TRIO_2 activity, induced cytoskeletal reorganization 18031682 2 0 0 regulates neuronal spines and Rac1 activation -C3AR1 C3aR GPCR, family 1; Membrane protein, integral; Membrane protein, multi-pass; Receptor, GPCR Q16581 719 12p13.31 human S465-p 27145808 FSEELTRsTHCPSNN receptor desensitization, induced; molecular association, regulation transcription, inhibited ARRB2(INDUCES) 23077507 1 0 0 -STAU1 STAU iso2 RNA-binding O95793-2 6780 20q13.13 human T21-p 1877718904 PYSRMQStYNYNMRG dsrm cell growth, induced 35806349 1 0 0 -MCTS1 MCTS1 Cell cycle regulation; Tumor suppressor Q9ULC4 28985 Xq24 human T81-p 26348501 REGPFYPtLRLLHKY Pre-PUA cell growth, induced 17016429 1 0 0 -NUMB NUMB iso3 Cell development/differentiation P49757-3 8650 14q24.2-q24.3 human S284-p 470030 SPFKRQLsLRINELP NumbF molecular association, regulation; intracellular localization endocytosis, inhibited AP2A1(DISRUPTS); CDH1(DISRUPTS); CTNND1(DISRUPTS) 21775625 4 9 17 -TRIM11 TRIM11 EC 6.3.2.-; EC 6.3.2.19; Ligase; UBIQUITIN LIGASE; Ubiquitin conjugating system; Ubiquitin ligase Q96F44 81559 1q42.13 human K458-ub 57951823 PMTICRPkGGSGDTL molecular association, regulation autophagy, induced SQSTM1(INDUCES) 27498865 1 0 0 promotes AIM2 degradation via SQSTM1-dependent autophagy -DRD1 DRD1 GPCR, family 1; Membrane protein, integral; Membrane protein, multi-pass; Receptor, GPCR P21728 1812 5q35.2 human T244-p 1869357204 HAKNCQTtTGNGKPV 7tm_1 molecular association, regulation ARR3(INDUCES) 32503917 1 0 0 -Trex1 TREX1 Cell cycle regulation; DNA repair, damage; DNA-binding; Deoxyribonuclease; EC 3.1.11.2 Q91XB0 22040 9|9 F2 mouse S78-p 2579811 IAPGKACsPGASEIT RNase_T transcription, altered RPN1(DISRUPTS) 28297665 1 9 0 -RND3 RhoE G protein; G protein, monomeric; G protein, monomeric, Rho; Motility/polarity/chemotaxis P61587 390 2q23.3 human S218-p 25307985 QRATKRIsHMPSRPE molecular association, regulation; intracellular localization cell cycle regulation; cytoskeletal reorganization 14-3-3 beta(INDUCES) 23622247; 32041905 2 2 1 -GRK1 GRK1 EC 2.7.11.14; KINASE; Kinase, protein; Protein kinase, AGC; Protein kinase, Ser/Thr (non-receptor) Q15835 6011 13q34 human S5-p 2528801 ___MDFGsLETVVAN molecular association, regulation Rhodopsin(INDUCES) 34262173 2 1 0 -GLI1 GLI1 C2H2-type zinc finger protein; Oncoprotein; Transcription factor P08151 2735 12q13.3 human S1071-p 51348700 SHDQRGSsGHTPPPS protein stabilization 26603838 1 1 0 -CDC25A CDC25A EC 3.1.3.48; Motility/polarity/chemotaxis; PHOSPHATASE; Protein phosphatase, dual-specificity P30304 993 3p21.31 human S18-p 449976 RRLLFACsPPPASQP protein degradation; protein stabilization; ubiquitination cell cycle regulation; apoptosis, inhibited CDK1(INDUCES) 12411508; 34363019 4 6 0 -Cdk2 CDK2 Cell cycle regulation; EC 2.7.11.22; KINASE; Kinase, protein; Protein kinase, CMGC; Protein kinase, Ser/Thr (non-receptor) P97377 12566 10|10 D3 mouse Y15-p 447740 EKIGEGTyGVVYKAK Pkinase enzymatic activity, inhibited cell cycle regulation; cell differentiation, induced; cell growth, altered 11509654; 20462953; 22331465 33 129 3845 regulates centrosome duplication -FERMT2 kindlin-2 Cytoskeletal; Motility/polarity/chemotaxis Q96AC1 10979 14q22.1 human Y193-p 6153405 SKTMTPTyDAHDGSP molecular association, regulation cell motility, induced; cell adhesion, induced FBLIM1(INDUCES) 26037143 1 2 2 FBLM1 is recruited to focal adhesions. required for cell spreading and migration -TET2 TET2 EC 1.14.11.n2; Oxidoreductase; Tumor suppressor Q6N021 54790 4q24 human K110-ac 63106402 LSGLLQIkKLKQDQK protein stabilization; molecular association, regulation; ubiquitination; methylation; enzymatic activity, induced DNA repair, induced DNMT1(INDUCES) DNA(INDUCES) 28107650 1 1 0 inhibits ubiquitination, protects against abnormal DNA methylation -CDKN1A p21Cip1 Cell cycle regulation; Inhibitor P38936 1026 6p21.2 human T55-p 1869957900 RWNFDFVtETPLEGD CDI activity, induced; protein stabilization; molecular association, regulation; intracellular localization cell differentiation, inhibited; cell cycle regulation; cell growth, inhibited; apoptosis, induced; signaling pathway regulation CDK2(INDUCES); MDM2(DISRUPTS); PPAR-gamma(INDUCES); CDK4(INDUCES) 31097688 1 0 0 regulates adipocyte metabolism and obesity -Foxo6 FOXO6 DNA-binding Q70KY4 329934 4|4 D2.1 mouse S184-p 2899100 TPRRRAVsMDNGAKF molecular association, regulation; intracellular localization transcription, induced; transcription, inhibited; transcription, altered DNA(DISRUPTS) 12857750; 15987244; 34082382 3 2 0 -Pde4b PDE4B EC 3.1.4.53; Nucleotide Metabolism - purine; Phosphodiesterase Q8VBU5 18578 4 C6|4 46.99 cM mouse S130-p 468390 SDSDYDLsPKAMSRN enzymatic activity, induced 26192746 1 26 5 -Usf1 USF1 DNA-binding; Transcription factor Q61069 22278 1 H3|1 79.4 cM mouse K235-ac 7378203 DCSMESTkSGQSKGG HLH transcription, altered 19303849 2 1 0 -CACB CACNA1C Channel, calcium; Membrane protein, integral; Membrane protein, multi-pass P15381 100101555 rabbit S533-p 453091 RISKSKFsRYWRRWN activity, inhibited 10692404 3 0 0 -KATNA1 KATNA1 EC 3.6.4.3; Hydrolase; Motility/polarity/chemotaxis O75449 11104 6q25.1 human S109-p 23117380 VPVERRPsPGPRKRQ ubiquitination cell cycle regulation 19287380 1 4 1 -PTEN PTEN Carbohydrate Metabolism - inositol phosphate; EC 3.1.3.16; EC 3.1.3.48; EC 3.1.3.67; Motility/polarity/chemotaxis; Nuclear receptor co-regulator; PHOSPHATASE; Phosphatase, lipid; Tumor suppressor P60484 5728 10q23.31 human S385-p 448650 RYSDTTDsDPENEPF molecular association, regulation; protein stabilization; enzymatic activity, inhibited; protein conformation; phosphorylation; enzymatic activity, altered cell cycle regulation; neural plasticity; chromatin organization, altered PTEN(INDUCES); PTEN(DISRUPTS) DNA(INDUCES) 11035045; 12077256; 17565999; 22413754; 24766807; 36155262 12 10 0 plays an important role in regulating spine density; regulates CHK1 phosphorylation and activation and H2AX phosphorylation; phosphorylation maintains PTEN as a monomer -ATP5IF1 ATPIF1 Inhibitor; Mitochondrial Q9UII2 93974 1p35.3 human S39-p 27444486 NVDRGAGsIREAGGA IATP molecular association, regulation ATP5A1(DISRUPTS); ATP5F1(DISRUPTS) 26387949; 30204502 2 11 0 -Mapk1 ERK2 EC 2.7.11.24; KINASE; Kinase, protein; Protein kinase, CMGC; Protein kinase, Ser/Thr (non-receptor) P63085 26413 16 A3|16 10.53 cM mouse T183-p 447593 HDHTGFLtEYVATRW Pkinase intracellular localization; enzymatic activity, induced carcinogenesis, induced; carcinogenesis, inhibited; cell growth, inhibited; transcription, induced; signaling pathway regulation; transcription, altered; neural plasticity; cell growth, induced; apoptosis, inhibited; cytoskeletal reorganization GAB1(INDUCES) 10593929; 10608864; 10867029; 11934884; 1319055; 15788406; 15975986; 16103085; 19004831; 21562256; 21706057; 21813649; 21887248; 21917714; 25584415; 34191798; 37160873; 7504457 1139 120 2416 -RHOB RHOB G protein; G protein, monomeric; G protein, monomeric, Rho; Motility/polarity/chemotaxis; Tumor suppressor P62745 388 2p24.1 human S185-p 2853110 ALQKRYGsQNGCINC molecular association, regulation; activity, inhibited endocytosis, induced; cytoskeletal reorganization PKN1(DISRUPTS) 18590726; 27503856 2 0 0 S185A mutant blocks NGF induced macropinocytosis -MED14 Trap170 Nuclear receptor co-regulator; Transcription, coactivator/corepressor O60244 9282 Xp11.4 human S986-p 452549 NEDDNPPsPIGGDMM transcription, induced 24049075 1 11 1 -Sstr3 SSTR3 GPCR, family 1; Membrane protein, integral; Membrane protein, multi-pass; Receptor, GPCR P30936 171044 7q34 rat S341-p 456708 RRILLRPsRRVRSQE receptor desensitization, altered; receptor internalization, altered 9295322 1 0 2 -Cldn2 Claudin-2 Cytoskeletal; Membrane protein, integral; Membrane protein, multi-pass O88552 12738 X|X F1 mouse S208-p 21690001 QPLATRSsPRSAQQP molecular association, regulation; intracellular localization LAMP2(DISRUPTS) 22825868 2 4 0 -AKT1 Akt1 EC 2.7.11.1; KINASE; Kinase, protein; Oncoprotein; Protein kinase, AGC; Protein kinase, Ser/Thr (non-receptor) P31749 207 14q32.33 human R15-me 1880119100 KEGWLHKrGEYIKTW molecular association, regulation; intracellular localization carcinogenesis, inhibited; cell motility, inhibited Sin1(INDUCES); PDK1(INDUCES) 35803962 1 0 0 AKT1-Arg 15 methylation is necessary for its translocation to the plasma membrane; PRMT5 KD blocks tumor cell metastasis -Elk1 ELK1 DNA-binding; Transcription factor P41969 13712 X A1.3|X 16.45 cM mouse S423-p 469193 LSTPVVLsPGPQKP_ molecular association, regulation transcription, inhibited Trap100(DISRUPTS); MED23(DISRUPTS); MED16(DISRUPTS) 27738173 2 3 5 -Oprm1 MOR-1 GPCR, family 1; Membrane protein, integral; Membrane protein, multi-pass; Receptor, GPCR P42866 18390 10 A1|10 1.85 cM mouse Y336-p 5397200 SCLNPVLyAFLDENF 7tm_1 activity, induced signaling pathway regulation 24061856 3 0 0 adenylyl cyclase activity increased; Grb/SOS/Ras-Raf1 pathway for conversion of Gi/Go-coupled receptor into RTK -SIRT6 SIRT6 DEACETYLASE; DEUBIQUITINASE; Deacetylase; EC 2.4.2.31; EC 3.5.1.-; Transferase Q8N6T7 51548 19p13.3 human K170-ub 40212801 GRLCTVAkARGLRAC SIR2 protein stabilization DNA repair, induced; transcription, inhibited 24043303 1 3 0 decrease in acetylation -Plk4 PLK4 EC 2.7.11.21; KINASE; Kinase, protein; Nucleolus; Protein kinase, Other; Protein kinase, Ser/Thr (non-receptor) Q64702 20873 3|3 B mouse S282-p 12654003 DVGTVEDsMDSGHAT protein degradation; ubiquitination 20100909 1 1 0 -TRAF3 TRAF3 UBIQUITIN LIGASE; Ubiquitin conjugating system; Ubiquitin ligase Q13114 7187 14q32.32 human S75-p 1875793002 CGHRFCEsCMAALLS cell growth, induced; apoptosis, inhibited; transcription, induced; signaling pathway regulation 34255829 0 1 0 induces NIK stabilization and NF-kB signaling -KCNJ11 Kir6.2 Channel, potassium; Membrane protein, integral; Membrane protein, multi-pass Q14654 3767 11p15.1 human T224-p 453090 MQVVRKTtSPEGEVV IRK_C receptor internalization, induced; activity, inhibited 23223335; 24101510 3 0 0 channel current is inhibited -Itk ITK EC 2.7.10.2; KINASE; Kinase, protein; Protein kinase, TK; Protein kinase, tyrosine (non-receptor) Q03526 16428 11 B1.1|11 27.75 cM mouse Y186-p 449834 ETLVIALyDYQTNDP SH3_1 phosphorylation 12842872 3 0 80 Itk Y186F retains partial activity; stimulates ERK phosphorylation -ULK1 ULK1 Autophagy; EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, Other; Protein kinase, Ser/Thr (non-receptor) O75385 8408 12q24.33 human S410-gl 1880900308 SPSPPCSsSPSPSGR protein stabilization; molecular association, regulation; phosphorylation autophagy, induced STX17(INDUCES); HSC70(DISRUPTS) 35931119 1 0 0 inhibits phosphorylation at S423 -TRPV6 TRPV6 Channel, calcium; Membrane protein, integral; Membrane protein, multi-pass Q9H1D0 55503 7q34 human T728-p 12173902 MPSVSRStSRSSANW activity, inhibited 19805577 1 0 0 involved in regulation of calcium influx by ATP -Tnnt2 TNNT2 Motility/polarity/chemotaxis; Motor P50752 21956 1 E4|1 59.32 cM mouse T207-p 449038 YIQKQAQtERKSGKR Troponin activity, induced 12832403 6 0 0 -Foxo1 FOXO1A DNA-binding; Nuclear receptor co-regulator; Oncoprotein; Transcription factor Q9R1E0 56458 3 C|3 23.19 cM mouse S319-p 449112 PRTSSNAsTISGRLS transcription, inhibited 12724332; 22848439 6 1 0 enhances hypoglycemic effect -ENG ENG Membrane protein, integral; Motility/polarity/chemotaxis; Receptor, misc. P17813 2022 9q34.11 human S634-p 465618 VAVAAPAsSESSSTN phosphorylation 16785228 1 1 0 required for threonine phosphorylation of ENG -Yap1 YAP1 Oncoprotein; Transcription, coactivator/corepressor Q2EJA0 363014 8q11 rat S363-p 3190672 TYHSRDEsTDSGLSM protein degradation apoptosis, induced; transcription, inhibited 27194756; 33568044 32 13 5 -SLC12A6 KCC3 Membrane protein, integral; Membrane protein, multi-pass; Transporter; Transporter, SLC family Q9UHW9 9990 15q14 human T991-p 4770536 SAYTYERtLMMEQRS SLC12 molecular association, regulation; activity, inhibited STLK3(INDUCES) 19665974; 24043619; 27485015; 27782176 5 13 1 -SYN1 SYN1 Vesicle P17599 281510 cow S553-p 448377 TRPPASPsPQRQAGP molecular association, regulation ACTB(INDUCES) 24849359 8 22 10 polymerized actin -IGBP1 IGBP1 Motility/polarity/chemotaxis; Phosphatase, regulatory subunit P78318 3476 Xq13.1 human K287-ub 21176770 LPDQGIAkAAPEEFR TAP42 protein degradation 23740247 1 4 0 -Il21r IL21R Membrane protein, integral; Receptor, cytokine Q9JHX3 60504 7|7 F3 mouse Y281-p 1270907 ESFFQPLyREHSGNF cell growth, altered 17234735 1 0 0 -Irs1 IRS1 Adaptor/scaffold; Motility/polarity/chemotaxis P35569 16367 1 C5|1 42.0 cM mouse S635-p 447507 YMPMSPKsVSAPQQI protein degradation signaling pathway regulation 15994203; 23142081; 31672472; 34234788 35 4 0 -SH3GLB1 endophilin B1 Apoptosis; Autophagy; EC 2.3.1.-; Mitochondrial; Transferase Q9Y371 51100 1p22.3 human T145-p 26318403 TSALNFLtPLRNFIE BAR receptor internalization, inhibited autophagy, inhibited; endocytosis, inhibited 27715385 2 0 0 -EXOSC9 EXOSC9 EC 3.1.13.-; Nucleolus; RNA processing; Ribonuclease Q06265 5393 4q27 human S394-p 3194468 APIILSDsEEEEMII molecular association, regulation SUMO2(INDUCES); SUMO1(INDUCES) 19217413 1 19 1 -RPS6KA1 p90RSK EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, AGC; Protein kinase, Ser/Thr (non-receptor); Translation Q15418 6195 1p36.11 human S380-p 447990 HQLFRGFsFVATGLM Pkinase_C protein degradation; ubiquitination; enzymatic activity, induced; phosphorylation cell motility, induced; transcription, induced; signaling pathway regulation 21183680; 30586719; 36791912; 37059179 66 48 64 ERK phosphorylation; induces EphA2 phosphorylation; PKC-ERK-Runx2-TGF?R1 signaling pathway -Ctnnd2 CTNND2 Actin-binding; Motility/polarity/chemotaxis O35927 18163 15|15 B2 mouse S300-p 14910701 RGSSPKQsPSRLAKS molecular association, regulation; intracellular localization cytoskeletal reorganization PSD-95(DISRUPTS); GRIP1(DISRUPTS) 20573893 1 1 1 -TRIM21 TRIM21 EC 6.3.2.-; Ligase; UBIQUITIN LIGASE; Ubiquitin conjugating system; Ubiquitin ligase P19474 6737 11p15.4 human K387-ac 1875282502 IWLWNKQkYEAGTYP SPRY molecular association, regulation TRIM21(DISRUPTS) 32796032 1 0 0 induces the antibody-dependent intracellular neutralization (ADIN) of the nonenveloped DNA virus adenovirus (AdV) type 5 ; Hyperacetylation of TRIM21 bLocks dimerization and ubiquitinalion -Cad CAD Amino Acid Metabolism - alanine, aspartate and glutamate; EC 2.1.3.2; EC 3.5.2.3; EC 6.3.5.5; Hydrolase; KINASE; Ligase; Nucleotide Metabolism - pyrimidine; Transferase P08955 101843763 hamster T456-p 451248 KVYFLPItPHYVTQV enzymatic activity, induced 10659854 10 1 0 -Sirt1 SIRT1 Apoptosis; DEACETYLASE; Deacetylase; EC 3.5.1.-; Nuclear receptor co-regulator Q923E4 93759 10|10 B4 mouse S434-p 22568200 LLIVIGSsLKVRPVA SIR2 enzymatic activity, induced transcription, induced; signaling pathway regulation 22195961 1 1 1 cAMP/PKA Pathway; lipid metabolism and fatty acid oxidation -ATP7A ATP7A Apoptosis; Cell development/differentiation; Chaperone; EC 3.6.3.54; Hydrolase; Membrane protein, integral; Membrane protein, multi-pass; Transporter; Transporter, ion channel; Vesicle Q04656 538 Xq21.1 human S1469-p 9768107 ASINSLLsDKRSLNS intracellular localization 19576997 1 7 0 required for post-Golgi exocytic trafficking (Cu -responsive) -CREBBP CBP ACETYLTRANSFERASE; Acetyltransferase; DNA-binding; EC 2.3.1.48; Motility/polarity/chemotaxis; Nuclear receptor co-regulator; Transcription, coactivator/corepressor Q92793 1387 16p13.3 human Y659-p 447690 HLLAEKIyKIQKELE KIX molecular association, regulation transcription, altered Myb(INDUCES); CBP(INDUCES) 12196545 2 1 0 -NPR1 ANPA EC 4.6.1.2; Guanylyl cyclase; KINASE; Kinase, protein; Lyase; Membrane protein, integral; Nucleotide Metabolism - purine; Protein kinase, RGC; Protein kinase, dual-specificity (receptor); Receptor, misc. P16066 4881 1q21.3 human T532-p 447513 RSAGSRLtLSGRGSN activity, induced; enzymatic activity, induced 28416574; 9528788 3 3 1 -Ric8a RIC8A GEF; GEF, misc. NP_001093990 293614 1q41 rat S522-p 3213321 ETMEGQLsSDPDSDP molecular association, regulation G-alpha i1(INDUCES) 29844055 1 5 0 G-alpha subunit guanine nucleotide exchange; G-alpha subunit folding -Nr3c1 GR DNA-binding; Mitochondrial; Nuclear receptor; Transcription factor P06537 14815 18 B3|18 21.09 cM mouse S152-p 3178932 ANLNRSTsRPENPKS GCR neural plasticity 35733193 12 11 6 -PTRH2 PTRH2 EC 3.1.1.29; Hydrolase; Mitochondrial Q9Y3E5 51651 17q23.1 human S5-p 4206801 ___MPSKsLVMEYLA intracellular localization apoptosis, altered; cell adhesion, altered 18703509 1 0 0 associated with anoikis (cell death induced by detachment from the extracellular matrix) -RUNX2 AML3 DNA-binding; Transcription factor Q13950 860 6p21.1 human T198-p 27728402 SGRGKSFtLTITVFT Runt molecular association, regulation transcription, induced DNA(INDUCES) 23389849 1 0 0 induction of MMP3 and MMP9 transcription, invasion of breast cancer cells -Cd226 DNAM-1 Cell adhesion; Immunoglobulin superfamily; Membrane protein, integral Q8K4F0 225825 18|18 E4 mouse Y319-p 454845 DDEKEDIyVNYPTFS receptor internalization, induced; protein degradation; molecular association, regulation; ubiquitination carcinogenesis, induced; cytoskeletal reorganization GRB2(INDUCES); Cbl-b(INDUCES); PIK3R1(INDUCES); VAV1(INDUCES) 26552706; 33053330 6 2 69 -Npr2 ANPB EC 4.6.1.2; Guanylyl cyclase; KINASE; Kinase, protein; Lyase; Membrane protein, integral; Nucleotide Metabolism - purine; Protein kinase, RGC; Protein kinase, dual-specificity (receptor); Receptor, misc. P16067 116564 5q22 rat S513-p 450027 RYHKGAGsRLTLSLR activity, induced 9624142 2 1 0 -Map4 MAP4 Cytoskeletal; Motility/polarity/chemotaxis P27546 17758 9 F2|9 59.83 cM mouse S737-p 476119 ATATARPsTLPARDV intracellular localization cell differentiation, inhibited; apoptosis, induced; cytoskeletal reorganization 30327268; 35902952 3 2 0 -PIK3CD PIK3CD Carbohydrate Metabolism - inositol phosphate; EC 2.7.1.153; KINASE; Kinase, lipid; Motility/polarity/chemotaxis O00329 5293 1p36.22 human Y524-p 454088 RRGSGELyEHEKDLV PI3Ka carcinogenesis, induced; cell growth, induced; apoptosis, inhibited 24213578 1 16 290 -Esrp2 RBM35B RNA-binding Q8K0G8 77411 8|8 D3 mouse K531-ub 52473100 AAQRCHKkMMKERYV RRM_1 carcinogenesis, inhibited; RNA splicing, induced; cell growth, inhibited 26522722 1 0 0 -Kcnb1 Kv2.1 Channel, cation; Channel, ligand-gated; Channel, potassium; Membrane protein, integral; Membrane protein, multi-pass P15387 25736 3q42 rat S15-p 473559 HGSRSTSsLPPEPME activity, inhibited 16917065 2 4 1 -SP3 SP3 C2H2-type zinc finger protein; DNA-binding Q02447 6670 2q31.1 human S73-p 1199100 CSKIGPPsPGDDEEE activity, induced; protein stabilization transcription, induced 17685427 1 19 0 -PDHA1 PDHA1 iso2 Amino Acid Metabolism - valine, leucine and isoleucine biosynthesis; Carbohydrate Metabolism - butanoate; Carbohydrate Metabolism - citrate (TCA) cycle; Carbohydrate Metabolism - glycolysis and gluconeogenesis; Carbohydrate Metabolism - pyruvate; EC 1.2.4.1; Mitochondrial; Oxidoreductase P08559-2 5160 Xp22.12 human S300-p 448258 TYRYHGHsMSDPGVS E1_dh cell growth, induced; transcription, induced 30226812 96 108 675 promotes cell proliferation, induced c-Myc and cyclin 1 expression -SHC3 SHC3 Adaptor/scaffold; Motility/polarity/chemotaxis Q92529 53358 9q22.1 human Y342-p 451258 DGSDHPYyNSIPSKM apoptosis, inhibited 12242309 3 3 8 -NTRK1 TrkA EC 2.7.10.1; KINASE; Kinase, protein; Membrane protein, integral; Oncoprotein; Protein kinase, TK; Protein kinase, tyrosine (receptor) P04629 4914 1q23.1 human Y680-p 447763 RDIYSTDyYRVGGRT PK_Tyr_Ser-Thr receptor internalization, altered; enzymatic activity, induced 15601748 14 3 10 -IRF3 IRF3 DNA-binding; Transcription factor Q14653 3661 19q13.33 human S398-p 449029 VDLHISNsHPLSLTS activity, induced; protein degradation; molecular association, regulation; intracellular localization autophagy, induced; transcription, induced; transcription, altered CALCOCO2(INDUCES); IRF3(INDUCES); CBP(INDUCES) 14703513; 18272581; 19153595; 25070846; 27992402; 35948267; 37330913; 9566918 10 2 0 GPR108 and Smurf1 mediated degradation requires NDP52; NDP52-dependent autophagic degradation of phosphorylated IRF3; GPR108 interacts with Smurf1, followed by the recruitment of IRF3 during viral infection -HSP90AA1 HSP90A Chaperone; Heat shock protein P07900 3320 14q32.31 human T425-p 30957300 KKCLELFtELAEDKE HSP90 molecular association, regulation; protein conformation PKCG(DISRUPTS) 24117238 1 0 0 affects its ATP-binding affinity and ATPase activity,; PKC? phosphorylation of chaperone Hsp90? triggers its own release from the Hsp90? chaperone machinery. -BST2 BST2 Cell development/differentiation; Membrane protein, GPI anchor; Membrane protein, integral Q10589 684 19p13.11 human K18-ub 14512105 VPMEDGDkRCKLLLG protein degradation; intracellular localization 20419159 1 1 0 inhibits BST2-mediated restriction on the release of KSHV and HIV-1 viral particles -Notch1 Notch 1 Membrane protein, integral; Motility/polarity/chemotaxis; Oncoprotein; Receptor, misc.; Transcription factor Q01705 18128 2 A3|2 18.91 cM mouse K1770-ac 18899512 FKVSEASkKKRREPL protein stabilization; ubiquitination 21499261 1 1 0 -Mef2d MEF2D DNA-binding; Transcription factor Q63943 17261 3 F1|3 38.78 cM mouse K432-ac 458892 THPHISIkSEPVSPS cell differentiation, induced; transcription, induced 16166628 1 0 0 -RUNX1 AML1 iso8 DNA-binding; Oncoprotein; Transcription factor Q01196-8 861 21q22.12 human S424-p 1308915 SMVGGERsPPRILPP RunxI activity, induced; molecular association, regulation cell growth, induced; transcription, induced; cell growth, altered HDAC1(DISRUPTS); HDAC3(DISRUPTS) 18003885; 21059642 2 0 2 increases RUNX1 trans-activation; increases marrow progenitor proliferation -NEDD4L NEDD4L EC 6.3.2.-; EC 6.3.2.19; Ligase; UBIQUITIN LIGASE; Ubiquitin conjugating system; Ubiquitin ligase Q96PU5 23327 18q21.31 human S448-p 453440 IRRPRSLsSPTVTLS activity, induced; protein stabilization; molecular association, regulation; ubiquitination; protein conformation; phosphorylation carcinogenesis, inhibited; signaling pathway regulation 14-3-3 sigma(INDUCES); 14-3-3 zeta(INDUCES); 14-3-3 epsilon(INDUCES); SLC22A11(DISRUPTS); 14-3-3 eta(INDUCES); NKCC2(DISRUPTS); SMAD3(DISRUPTS); 14-3-3 beta(INDUCES); ENaC-alpha(DISRUPTS); 14-3-3 gamma(INDUCES); ENaC-beta(DISRUPTS); ENaC-alpha(INDUCES) 11742982; 15328345; 15677482; 16716084; 19917253; 21852580; 24657276; 30453017; 34294877; 37494179 16 64 53 inhibits NCC ubiquitination, SGK1-Nedd4-2 Pathway; induces ubiquitination and degradation of HIF1A -NKX3-1 NKX3-1 DNA-binding; Transcription factor; Tumor suppressor Q99801 4824 8p21.2 human S195-p 4913200 LGDLEKHsSLPALKE protein degradation; ubiquitination 18757402 2 1 0 -EEF2K EEF2K EC 2.7.11.20; KINASE; Kinase, protein; Protein kinase, Ser/Thr (non-receptor); Protein kinase, atypical; Translation O00418 29904 16p12.2 human S78-p 450687 SSGSPANsFHFKEAW molecular association, regulation; enzymatic activity, inhibited; enzymatic activity, induced cell growth, induced; autophagy, inhibited Calmodulin(DISRUPTS) 15024086; 21112387; 22216903; 23182879 7 14 0 -AR AR DNA-binding; Nuclear receptor; Transcription factor P10275 367 Xq12 human K631-ac 458906 GMTLGARkLKKLGNL activity, induced; protein stabilization; molecular association, regulation; intracellular localization; phosphorylation carcinogenesis, induced; carcinogenesis, inhibited; apoptosis, induced; transcription, induced; transcription, altered; signaling pathway regulation; cell growth, induced; apoptosis, inhibited HDAC1(DISRUPTS); N-CoR1(DISRUPTS); p300(INDUCES); SMAD3(DISRUPTS) DNA(INDUCES) 10779504; 11971970; 11994312; 14612401; 15123687; 16860317; 17483368; 18022799; 22131404; 28511652 11 1 0 -GMNN Geminin Cell cycle regulation; Motility/polarity/chemotaxis O75496 51053 6p22.3 human S202-p 475944 AEGTVSSsTDAKPCI apoptosis, altered 17261582 1 0 0 regulates geminin cleavage by caspase-3 -PAK1 PAK1 EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, STE; Protein kinase, Ser/Thr (non-receptor) Q13153 5058 11q13.5-q14.1 human Y153-p 463955 TDKSAEDyNSSNALN protein stabilization; molecular association, regulation; intracellular localization; enzymatic activity, induced carcinogenesis, induced; apoptosis, altered; cell motility, induced; transcription, induced; signaling pathway regulation; cell growth, induced; cell motility, altered; cytoskeletal reorganization GIT1(INDUCES); ARHGEF7(INDUCES); Snail1(INDUCES) 17726028; 21566085; 21719533; 23340249; 25125660; 25466889; 26944939; 27003261; 27542844 9 1 21 PAK1 phosphorylation stimulates PRL-induced tumor metastasis -SMAD3 SMAD3 DNA-binding; Nuclear receptor co-regulator; Transcription factor P84022 4088 15q22.33 human S416-p 3193766 KVLTQMGsPSIRCSS intracellular localization 18760948 1 3 0 nuclear translocation -GSK3B GSK3B EC 2.7.11.1; EC 2.7.11.26; KINASE; Kinase, protein; Protein kinase, CMGC; Protein kinase, Ser/Thr (non-receptor) P49841 2932 3q13.33 human T43-p 456221 KVTTVVAtPGQGPDR enzymatic activity, induced 18451303 2 2 0 -Kcnd3 Kv4.3 Channel, potassium; Membrane protein, integral; Membrane protein, multi-pass Q62897 65195 2q34 rat S535-p 3681504 YPSTRSPsLSSHSGL DUF3399 activity, inhibited 18599872 1 0 0 -PIK3R6 PIK3R6 Q5UE93 146850 17p13.1 human T607-p 10799542 SHRPREVtVSLRATG PI3K_1B_p101 molecular association, regulation; intracellular localization; enzymatic activity, inhibited; protein conformation carcinogenesis, inhibited; cell motility, inhibited PIK3CG(INDUCES) 25753393 1 0 1 -Kcnma1 KCNMA1 Channel, potassium; Endoplasmic reticulum; Membrane protein, integral; Membrane protein, multi-pass Q08460 16531 14|14 A3 mouse Y831-p 11502400 VFVGSIEyLKREWET activity, induced 19887442 1 0 0 -SUFU SUFU Adaptor/scaffold; Transcription, coactivator/corepressor; Tumor suppressor Q9UMX1 51684 10q24.32 human S352-p 20652725 DSLESDSsTAIIPHE SUFU_C molecular association, regulation FBXL17(DISRUPTS) 27234298 1 1 1 -ITCH ITCH EC 6.3.2.-; EC 6.3.2.19; Ligase; UBIQUITIN LIGASE; Ubiquitin conjugating system; Ubiquitin ligase Q96J02 83737 20q11.22 human S257-p 83110609 PSRPPRPsRPPPPTP ubiquitination; intracellular localization carcinogenesis, induced; signaling pathway regulation 30517763 1 2 0 ; H1.2 ubiquitination; translocation to nucleus -Bid BID Apoptosis; Mitochondrial P70444 12122 6 F1|6 57.02 cM mouse S66-p 14570494 DGSQASRsFNQGRIE BID cell cycle regulation; apoptosis, induced 24767991 2 5 0 -RNF157 RNF157 UBIQUITIN LIGASE; Ubiquitin conjugating system; Ubiquitin ligase Q96PX1 114804 17q25.1 human S660-p 4334560 NAQRRRLsSSSLEDS protein degradation; molecular association, regulation; ubiquitination CDH1(INDUCES) 28655764 1 1 3 -Sdc2 syndecan-2 Cell adhesion; Cell surface; Membrane protein, integral; Motility/polarity/chemotaxis P34900 25615 7q22 rat Y191-p 448376 RKPSSAAyQKAPTKE Syndecan molecular association, regulation cytoskeletal reorganization EphB2(INDUCES) 11580899 1 5 6 -SREBF1 SREBP-1 DNA-binding; Membrane protein, integral; Membrane protein, multi-pass; Transcription factor P36956 6720 17p11.2 human R321-m2 53350800 APASAQSrGEKRTAH protein stabilization; molecular association, regulation cell growth, induced; transcription, induced FBXW7(DISRUPTS) 26759235 1 1 0 PRMT5 knockdown caused faster degradation, PRMT5-induced methylation prevented phosphorylation of SREBP1A on S430 -Aqp2 AQP2 Channel, misc.; Membrane protein, integral; Membrane protein, multi-pass; Transporter; Transporter, aquaporin family P56402 11827 15 F1|15 56.13 cM mouse K270-ub 999601 QSLPRGSkA______ protein stabilization; ubiquitination 24876223; 28052875 6 0 0 -Itpr1 IP3R1 Channel, calcium; Channel, ligand-gated; Membrane protein, integral; Membrane protein, multi-pass P11881 16438 6 E1|6 49.74 cM mouse S436-p 469626 AFAIVPVsPAEVRDL activity, induced; molecular association, regulation; activity, inhibited 16925983; 16979595; 26259730 3 2 0 enhance Ca2+ oscillations, enhance the sensitivity of IP3R1; inhibits binding to IP3 in vitro and IP3R1-mediated intracellular calcium release in vivo; reduces intracellular calcium release in response to anti-IgM stimulation -HSF1 HSF1 DNA-binding; Transcription factor Q00613 3297 8q24.3 human K208-ac 31953302 RILGVKRkIPLMLND protein stabilization; protein conformation 24581496 1 1 0 -MITF MITF DNA-binding; Oncoprotein; Transcription factor O75030 4286 3p13 human Y360-p 50783666 ILKASVDyIRKLQRE HLH protein degradation; molecular association, regulation autophagy, induced SQSTM1(INDUCES) 35092699 1 1 0 -EGFR EGFR EC 2.7.10.1; KINASE; Kinase, protein; Membrane protein, integral; Oncoprotein; Protein kinase, TK; Protein kinase, tyrosine (receptor) P00533 1956 7p11.2 human K37-sm 49199200 VCQGTSNkLTQLGTF transcription, induced 26244656 1 1 0 -Pbk PBK Cancer Testis Antigen (CTA); EC 2.7.12.2; KINASE; Kinase, protein; Protein kinase, Other; Protein kinase, Ser/Thr (non-receptor); Protein kinase, dual-specificity (non-receptor) Q9JJ78 52033 14 D1|14 34.36 cM mouse T9-p 451735 EGINNFKtPNKSEKR phosphorylation; enzymatic activity, induced cell cycle regulation; cell growth, induced; apoptosis, inhibited; signaling pathway regulation 16291951; 35678915 6 12 2 activated in the mitotic cells; induces AKT phosphorylation and signaling -Stk39 STLK3 EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, STE; Protein kinase, Ser/Thr (non-receptor) Q9Z1W9 53416 2|2 C1.3 mouse T243-p 456505 TRNKVRKtFVGTPCW Pkinase enzymatic activity, induced cell cycle regulation; cell motility, induced; cell growth, induced; cell adhesion, inhibited 16382158; 20463172; 21486947; 36662229 12 5 51 -GSK3B GSK3B EC 2.7.11.1; EC 2.7.11.26; KINASE; Kinase, protein; Protein kinase, CMGC; Protein kinase, Ser/Thr (non-receptor) P49841 2932 3q13.33 human K205-ac 27738300 LCDFGSAkQLVRGEP Pkinase intracellular localization; phosphorylation carcinogenesis, induced; cell growth, induced; apoptosis, inhibited; transcription, inhibited; signaling pathway regulation 25915842 2 0 0 induces phosphorylation of itself, inhibits transcription and localization of Bax, regulates Bax signaling -SNCA SNCA Adaptor/scaffold P37840 6622 4q22.1 human T75-gl 1498941802 GAVVTGVtAVAQKTV Synuclein protein stabilization 30651314 0 1 0 inhibits the aggregation of alpha-synuclein but can also alter the structure of a-synuclein aggregates in site specific ways, inhibit a-Synuclein toxicity -KCNMA1 KCNMA1 Channel, potassium; Endoplasmic reticulum; Membrane protein, integral; Membrane protein, multi-pass Q8AYS8 374065 chicken T989-p 485931 ALRGGYStPQTLANR intracellular localization 22094329 1 5 3 -SGO1 SGO1 Cell cycle regulation Q5FBB7 151648 3p24.3 human S14-p 486241 LKKSFQDsLEDIKKR chromatin organization, altered 17621308 1 0 0 required for proper association between the kinetochore and spindle microtubules -WIPI2 WIPI2 Autophagy Q9Y4P8 26100 7p22.1 human S413-p 3217428 KGTYVPSsPTRLAYT autophagy, inhibited 36476874 1 26 5 -LRRK2 LRRK2 EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, Ser/Thr (non-receptor); Protein kinase, TKL Q5S007 120892 12q12 human S935-p 4725898 NLQRHSNsLGPIFDH protein stabilization; molecular association, regulation; ubiquitination; enzymatic activity, inhibited; intracellular localization; phosphorylation 14-3-3 beta(INDUCES); 14-3-3 sigma(INDUCES); 14-3-3 theta(INDUCES); 14-3-3 zeta(INDUCES); 14-3-3 epsilon(INDUCES); 14-3-3 gamma(INDUCES); 14-3-3 eta(INDUCES) 20642453; 20659021; 21378983; 22004453; 24942733; 25009464; 32317922; 32601174; 34144124; 35266954 43 17 2 -Ppp1r12a MYPT1 Motility/polarity/chemotaxis; PHOSPHATASE; Protein phosphatase, regulatory subunit Q10728 116670 7q21 rat S854-p 451999 RPREKRRsTGVSFWT intracellular localization 10579722 9 2 13 -BACE1 BACE EC 3.4.23.46; Membrane protein, integral; Protease P56817 23621 11q23.3 human K299-ac 478253 TTNLRLPkKVFEAAV Asp protein stabilization; intracellular localization 17425515 1 1 0 regulates translocation through secretory pathway -RPA1 RPA1 DNA-binding P27694 6117 17p13.3 human K577-sm 1872852102 FIFRVRVkVETYNDE Rep_fac-A_C DNA repair, induced 22661229 1 0 0 -DGCR8 DGCR8 Nucleolus; RNA processing; RNA-binding Q8WYQ5 54487 22q11.21 human S92-p 3208086 LLIDPNCsGHSPRTA protein stabilization 24239349 0 13 0 -DAPK1 DAPK1 Apoptosis; Autophagy; EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, CAMK; Protein kinase, Ser/Thr (non-receptor) P53355 1612 9q21.33 human S289-p 457379 QALSRKAsAVNMEKF activity, inhibited; enzymatic activity, induced apoptosis, altered; signaling pathway regulation 16213824; 31116076 2 8 24 Phosphorylation of site suppresses apoptotic activity of DAPK; MAPK-DAPK1 signaling pathway -THRA TR-alpha DNA-binding; Nuclear receptor; Transcription factor NP_990644 396251 chicken K134-ac 10769108 SKRVAKRkLIEENRE molecular association, regulation carcinogenesis, inhibited; transcription, altered SMRT(DISRUPTS); ACTR1A(INDUCES) DNA(INDUCES) 19819978 1 0 0 induces transactivation and transrepression of transcription -Nfya NFYA DNA-binding; Transcription factor P23708 18044 17 C|17 23.99 cM mouse K289-ub 4664702 AKLEAEGkIPKERRK CBFB_NFYA protein degradation cell growth, inhibited; transcription, inhibited 18815279 1 0 0 -HIPK2 HIPK2 EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, CMGC; Protein kinase, Ser/Thr (non-receptor) Q9H2X6 28996 7q34 human K552-ub 3059902 FQNMEICkRRVNMYD protein degradation 18536714 1 2 0 -EEF1A2 EEF1A2 Translation; Translation elongation Q05639 1917 20q13.33 human S21-p 5434143 GHVDSGKsTTTGHLI GTP_EFTU protein degradation; ubiquitination apoptosis, induced 22378069 1 4 5 -CD247 CD3Z Membrane protein, integral; Receptor, misc. P20963 919 1q24.2 human Y72-p 448936 QQGQNQLyNELNLGR ITAM phosphorylation 16919488 3 12 369 required for ERK phosphorylation after SDF1a treatment -Eif4e EIF4E Translation; Translation initiation P63073 13684 3 G3|3 64.3 cM mouse T210-p 450199 TATKSGStTKNRFVV molecular association, regulation; protein conformation eIF4G(INDUCES) 9878069 3 2 0 -Mos MOS EC 2.7.11.1; KINASE; Kinase, protein; Oncoprotein; Protein kinase, Other; Protein kinase, Ser/Thr (non-receptor) P00536 17451 4 A1|4 2.16 cM mouse S16-p 466945 RYLPRELsPSVDSRS protein stabilization; molecular association, regulation cell growth, altered 10439036 2 1 0 -SERINC5 SERINC5 Membrane protein, integral; Membrane protein, multi-pass Q86VE9 256987 5q14.1 human K130-ub 1883494503 HNGFWFFkLLLLGAM Serinc intracellular localization 35474067 1 1 0 downregulation by HIV-1 Nef, required for SERINC5 anti-HIV-1 activity -PITX1 PITX1 Cell development/differentiation; DNA-binding; Transcription factor P78337 5307 5q31.1 human Y160-p 54204601 LDLCKGGyVPQFSGL protein degradation; protein stabilization transcription, inhibited 26840794; 27752061 2 0 0 -TAB3 TAB3 Adaptor/scaffold Q8N5C8 257397 Xp21.2 human T404-p 1295506 HSLYTATtPPSSSPS O-GlcNAc glycosylation 27009840 2 6 4 increased TAB3 T404 phosphoryaltion -Cftr CFTR Channel, chloride; EC 3.6.3.49; Hydrolase; Membrane protein, integral; Membrane protein, multi-pass; Transporter; Transporter, ABC family P26361 12638 6 A2|6 8.1 cM mouse S737-p 3116903 RLSLVPDsEQGEAAL CFTR_R activity, induced 35353541 1 2 0 -CTNNB1 CTNNB1 Actin-binding; Cell adhesion; Motility/polarity/chemotaxis; Nuclear receptor co-regulator; Oncoprotein; Transcription factor P35222 1499 3p22.1 human Y86-p 447584 VADIDGQyAMTRAQR protein stabilization; molecular association, regulation; ubiquitination; intracellular localization carcinogenesis, induced; cell growth, induced; transcription, induced; transcription, altered; cell growth, altered TCF4(INDUCES); TBN(INDUCES); axin 1(DISRUPTS) 17318191; 20840866; 35697802 9 1 22 inhibits ubiquitination -Ndel1 NDEL1 Microtubule-binding; Protease Q9ERR1 83431 11|11 B3 mouse S198-p 474508 TRKSAPSsPTLDCEK NUDE_C activity, induced; intracellular localization cell motility, altered 18331715 4 25 0 Cdc42 activation -ARHGEF7 ARHGEF7 GEF; GEF, Rac/Rho; Motility/polarity/chemotaxis Q14155 8874 13q34 human Y620-p 3753309 PAPLTPAyHTLPHPS activity, induced; molecular association, regulation cell growth, altered EGFR(INDUCES); CDC42 iso1(INDUCES); Cbl-b(INDUCES) 16892055 3 0 4 GEF activity for Cdc42 -Eif3f eIF3-epsilon EC 3.4.19.12; Translation; Translation initiation Q9DCH4 66085 7|7 E3 mouse K301-ub 7388008 AEDVLSGkVSADNTV MitMem_reg protein degradation 19073596 1 1 0 regulates skeletal muscle atrophy -KCNJ4 HIR Channel, potassium; Membrane protein, integral; Membrane protein, multi-pass P48050 3761 22q13.1 human Y234-p 19003800 YMTQEGEyLPLDQRD IRK_C activity, induced 21486282 1 0 0 increased channel current -CTNNB1 CTNNB1 Actin-binding; Cell adhesion; Motility/polarity/chemotaxis; Nuclear receptor co-regulator; Oncoprotein; Transcription factor XP_008258482 100125985 rabbit S552-p 472273 QDTQRRTsMGGTQQQ intracellular localization cell differentiation, induced 34094857 44 64 9 -GGA3 GGA3 Adaptor/scaffold; Vesicle Q9NZ52 23163 17q25.1 human S368-p 456842 QASGPPRsRSSSQAE molecular association, regulation; protein conformation 16135791 1 0 0 phosphorylation of this residue regulates the association of GGA3 with membranes -ABL2 Arg EC 2.7.10.2; KINASE; Kinase, protein; Oncoprotein; Protein kinase, TK; Protein kinase, tyrosine (non-receptor) P42684 27 1q25.2 human Y116-p 2226537 PNLFVALyDFVASGD SH3_1 enzymatic activity, induced 34144039 1 2 9 -Tbc1d4 AS160 GAP; GAP, Rab Q8BYJ6 210789 14|14 E2.3 mouse S764-p 3175636 SSTCSNEsLNAGGTP phosphorylation 33872597 1 18 71 affects phosphorylation of other sites by AKT -Cd79a Ig-alpha Immunoglobulin superfamily; Membrane protein, integral P11911 12518 7 A3|7 13.49 cM mouse S191-p 17342617 GLNLDDCsMYEDISR ITAM phosphorylation signaling pathway regulation 21841126 1 0 4 modulates T cell independent type II Ag response; phosphorylation at this site inhibits in vivo phosphorylation of tyrosine in Ig alpha -SDHA SDHA Carbohydrate Metabolism - citrate (TCA) cycle; EC 1.3.5.1; Energy Metabolism - oxidative phosphorylation; Mitochondrial; Oxidoreductase; Tumor suppressor P31040 6389 5p15.33 human Y215-p 25682901 SLRYDTSyFVEYFAL FAD_binding_2 apoptosis, inhibited 22823520 2 0 0 -Rbck1 RBCK1 EC 6.3.2.-; Ligase; UBIQUITIN LIGASE; Ubiquitin conjugating system; Ubiquitin ligase Q62921 rat T161-p 2103604 DLGFKDLtLQPRGPL protein stabilization 18303026 1 0 0 inhibits self-ubiquitination of RBCK1 in vitro -Myrf MRF DNA-binding; Membrane protein, integral Q3UR85 225908 19|19 A mouse S138-p 20804934 APGTLPDsPPDSGSE protein degradation; ubiquitination 29472293 1 1 0 -Gria2 GluR2 Channel, calcium; Channel, ligand-gated; Membrane protein, integral; Membrane protein, multi-pass P19491 29627 2q33 rat K870-ub 27191129 SQNFATYkEGYNVYG protein degradation; intracellular localization 25660027 2 1 0 -STING1 STING Apoptosis; Endoplasmic reticulum; Membrane protein, integral; Membrane protein, multi-pass; Mitochondrial Q86WV6 340061 5q31.2 human K150-ub 7388017 EISAVCEkGNFNVAH TMEM173 protein degradation; intracellular localization transcription, inhibited; signaling pathway regulation 19285439 2 0 0 regulation of virus-triggered signaling and antiviral response via IRF3 activation -Ksr2 KSR2 EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, Ser/Thr (non-receptor); Protein kinase, TKL Q3UVC0 333050 5|5 F mouse S314-p 4721664 TALHRSKsHEFQLGN molecular association, regulation; intracellular localization 14-3-3 beta(INDUCES) 19560418 1 5 0 -Scn2a SCN2A Channel, sodium; Membrane protein, integral; Membrane protein, multi-pass P04775 24766 3q21 rat S573-p 451193 LFSPRRNsRASLFNF Na_trans_cytopl activity, inhibited 12359152; 9236220; 9295379 4 2 1 reduces peak Na(+) current. -Stk11 LKB1 Autophagy; EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, CAMK; Protein kinase, Ser/Thr (non-receptor); Tumor suppressor Q9WTK7 20869 10|10 C1 mouse Y261-p 13258700 PFEGDNIyKLFENIG Pkinase molecular association, regulation; intracellular localization; phosphorylation cell differentiation, induced; signaling pathway regulation PLCG1(INDUCES); LAT(INDUCES); Fyn(INDUCES) 20142099; 21487392; 24586906 3 0 0 TCR signaling, recruitment of PLCG1 to the LAT signalosome; mutation of this site increses AMPK phosphorylation; LKB1 cytosolic localization, induced AMPK phosphorylation -TUBA1A TUBA1A Cytoskeletal; Motility/polarity/chemotaxis Q71U36 7846 12q13.12 human K304-sm 1881132901 EPANQMVkCDPRHGK sumoylation cytoskeletal reorganization 33394042 1 0 0 promotes microtubule catastrophe, attenuates MT polymerization, facilitates neurite extension -PHOX2A PHOX2A DNA-binding; Transcription factor O14813 401 11q13.4 human S202-p 9400303 PPAPGLAsPRLSPSP phosphorylation 19564421 1 1 0 regulates phosphorylation of PHOX2A S153 -DOCK8 DOCK8 GEF; GEF, misc.; Motility/polarity/chemotaxis Q8NF50 81704 9p24.3 human S2082-p 3929310 VESQKRDsFHRSSFR molecular association, regulation cell motility, induced LRCH1(DISRUPTS) 28028151 1 5 7 -GPR26 GPR26 GPCR, family 1; Membrane protein, integral; Membrane protein, multi-pass; Receptor, GPCR Q8NDV2 2849 10q26.13 human K286-ub 1881186503 SKCLAYSkAASDPFV protein degradation; ubiquitination carcinogenesis, inhibited; cell growth, inhibited 33577134 1 0 0 K286R inhibited ubiquitylation, increased protein expression and induced an antitumor function in liver cancer cells. -Ipmk IPMK Carbohydrate Metabolism - inositol phosphate; EC 2.7.1.151; Kinase, other; Motility/polarity/chemotaxis Q99NI4 171458 20p11 rat Y174-p 22826100 YHLHSDSyETQNQHY IPK molecular association, regulation AMPKA2(INDUCES) 22203993 1 0 0 -CKAP4 CKAP4 Endoplasmic reticulum; Membrane protein, integral Q07065 10970 12q23.3 human S19-p 455355 GHGAASPsEKGAHPS molecular association, regulation; intracellular localization; palmitoylation neural plasticity; cell growth, inhibited; cytoskeletal reorganization; transcription, altered; signaling pathway regulation DNA(INDUCES) 15703217; 22265418; 22536245 3 1 0 -UHRF1 UHRF1 DNA-binding; EC 6.3.2.-; EC 6.3.2.19; Ligase; Transcription factor; UBIQUITIN LIGASE; Ubiquitin conjugating system; Ubiquitin ligase Q96T88 29128 19p13.3 human K490-ac 1875274100 GRDLSGNkRTAEQSC SAD_SRA molecular association, regulation cell cycle regulation; chromatin organization, altered DNA(DISRUPTS) 32726623 1 1 0 inhibits chromatin association; attenuates binding afinity to hemi-methylated DNA; disrupts the inheritance of global DNA methylation patterns -DUSP1 DUSP1 EC 3.1.3.16; EC 3.1.3.48; Motility/polarity/chemotaxis; PHOSPHATASE; Protein phosphatase, dual-specificity P28562 1843 5q35.1 human S359-p 448660 SALSYLQsPITTSPS protein stabilization 10617468; 25204653 4 0 0 -CTNND1 CTNND1 Actin-binding; Adaptor/scaffold; Cell adhesion; G protein regulator, misc.; Motility/polarity/chemotaxis O60716 1500 11q12.1 human Y96-p 449495 QDHSHLLySTIPRMQ intracellular localization 26302406 4 35 735 Y228 and Y96 basolateral localization, T310 was both apically and basoleterally localized -CILK1 ICK EC 2.7.11.22; KINASE; Kinase, protein; Protein kinase, CMGC; Protein kinase, Ser/Thr (non-receptor) Q9UPZ9 22858 6p12.1 human T157-p 456051 IRSKPPYtDYVSTRW Pkinase intracellular localization cytoskeletal reorganization 32732286 3 21 86 induces IFT accumulation at cilia tips -Rbbp8 CtIP EC 3.1.-.-; Transcription, coactivator/corepressor Q80YR6 225182 18|18 A1 mouse T843-p 7113805 FRYIPPNtPENFWEV SAE2 DNA repair, induced; cell growth, inhibited; cell growth, induced; transcription, inhibited 31097467; 36640339 7 1 1 -Plcg2 PLCG2 Carbohydrate Metabolism - inositol phosphate; EC 3.1.4.11; Motility/polarity/chemotaxis; Phospholipase P24135 29337 19q12 rat Y753-p 447940 ERDINSLyDVSRMYV enzymatic activity, induced 11507089 10 11 270 -Sh3rf1 SH3RF1 Adaptor/scaffold; EC 6.3.2.-; EC 6.3.2.19; Ligase; UBIQUITIN LIGASE; Ubiquitin conjugating system; Ubiquitin ligase Q69ZI1 59009 8|8 B3.1 mouse S304-p 482847 KNTRKRHsFTSLTMA cell cycle regulation; cell growth, inhibited; cell differentiation, induced; signaling pathway regulation 30361695 2 18 22 Suppression of JNK signaling -TERF1 TRF1 DNA-binding P54274 7013 8q21.11 human S219-p 448475 SKLLMIIsQKDTFHS TRF apoptosis, inhibited 11375976 1 0 0 -KLF1 KLF1 C2H2-type zinc finger protein; DNA-binding; Transcription factor Q13351 10661 19p13.13 human K274-ac 460630 GRRSWARkRQAAHTC activity, induced; molecular association, regulation transcription, induced 11259590; 9707565 3 0 0 -CHAT CHAT iso3 ACETYLTRANSFERASE; Acetyltransferase; EC 2.3.1.6; Lipid Metabolism - glycerophospholipid P28329-3 1103 10q11.23 human S440-p 449057 VPTYESAsIRRFQEG Carn_acyltransf activity, induced; enzymatic activity, induced 12486117; 15381704 2 1 0 -DKC1 dyskerin EC 5.4.99.-; Isomerase; Lyase; Nucleolus; RNA processing; RNA-binding O60832 1736 Xq28 human K467-sm 1881186501 PAAPQLIkKEKKKSK intracellular localization NOLA1(INDUCES) 33526451 1 0 0 disrupts subnuclear localization -KAT5 Tip60 ACETYLTRANSFERASE; Acetyltransferase; EC 2.3.1.48; Nuclear receptor co-regulator; Nucleolus Q92993 10524 11q13.1 human K430-sm 1968600 LEILMGLkSESGERP MOZ_SAS intracellular localization; enzymatic activity, induced DNA repair, induced 17704809 1 0 0 -MFN2 MFN2 Cell cycle regulation; Cytoskeletal; EC 3.6.5.-; Hydrolase; Membrane protein, integral; Membrane protein, multi-pass; Mitochondrial O95140 9927 1p36.22 human S378-p 1877509600 AVRLIMDsLHMAARE autophagy, induced 35646911 1 0 0 miophagy -MYC Myc DNA-binding; Nucleolus; Oncoprotein; Transcription factor P01106 4609 8q24.21 human T259-p 1876391100 PLVLHEEtPPTTSSD Myc_N protein degradation; molecular association, regulation; ubiquitination FBXW7(INDUCES) 35089787 1 0 0 -DLD DLD Amino Acid Metabolism - glycine, serine and threonine; Amino Acid Metabolism - valine, leucine and isoleucine degradation; Carbohydrate Metabolism - citrate (TCA) cycle; Carbohydrate Metabolism - glycolysis and gluconeogenesis; Carbohydrate Metabolism - pyruvate; EC 1.8.1.4; Mitochondrial; Oxidoreductase P09622 1738 7q31.1 human T135-p 18262251 STAVKALtGGIAHLF Pyr_redox_2 enzymatic activity, induced 29358703 1 3 0 -BCL3 Bcl-3 Apoptosis; Nuclear receptor co-regulator; Oncoprotein; Transcription regulation P20749 602 19q13.32 human K34-ub 3627523 GAALPLRkRPLRAPS protein degradation transcription, altered 15469820 1 0 0 -SREBF1 SREBP-1 iso3 DNA-binding; Membrane protein, integral; Membrane protein, multi-pass; Transcription factor P36956-3 6720 17p11.2 human S372-p 4934079 TAVHKSKsLKDLVSA protein stabilization; intracellular localization; activity, inhibited transcription, induced; transcription, inhibited 21459323; 30733434; 33675805 3 1 6 inhibits proteolytic processing; inhibits lipogenesis -KRAS KRas G protein; G protein, monomeric; G protein, monomeric, Ras; Motility/polarity/chemotaxis; Oncoprotein P01116 3845 12p12.1 human K147-ub 15391092 PFIETSAkTRQRVED Ras molecular association, regulation; enzymatic activity, induced RAF1(DISRUPTS); RASA1(DISRUPTS); RALGDS(DISRUPTS); PIK3CG(DISRUPTS) 24030601; 29185849 4 6 3 Mant-?uorescence binding assay, enhanced (40-fold) binding to the CRAF RBD when bound to GDP -XIAP XIAP Apoptosis; EC 6.3.2.-; Ligase; UBIQUITIN LIGASE; Ubiquitin conjugating system; Ubiquitin ligase P98170 331 Xq25 human K328-ub 22254948 AKWYPGCkYLLEQKG BIR protein degradation 22072751 1 2 0 -POU5F1 Oct4 DNA-binding; Transcription factor Q01860 5460 6p21.33 human K156-ac 57951802 FAKLLKQkRITLGYT Pou protein stabilization; molecular association, regulation transcription, induced SOX2(INDUCES) 27369080 1 1 0 -BCL2L11 BIM Apoptosis O43521 10018 2q13 human S94-p 4698178 SLLSRSSsGYFSFDT protein degradation; molecular association, regulation; ubiquitination BTRC(INDUCES) 23912711 1 6 0 -Wnk4 WNK4 EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, Other; Protein kinase, Ser/Thr (non-receptor) Q80UE6 69847 11|11 D mouse K1137-ub 40323303 ALQTLQKkEIEDLYS protein degradation 23576762 1 1 0 regulates electrolyte homeostasis and involved in Pseudohypoaldosteronism type II (PHAII) pathogenesis -Pdx1 PDX1 DNA-binding; Transcription factor P52946 18609 5 G3|5 86.84 cM mouse S66-p 458402 QGSPPDIsPYEVPPL protein degradation 16407209 3 0 0 -TTK TTK Cancer Testis Antigen (CTA); EC 2.7.12.1; KINASE; Kinase, protein; Protein kinase, Other; Protein kinase, dual-specificity (non-receptor) P33981 7272 6q14.1 human S821-p 467281 GQLVGLNsPNSILKA intracellular localization 18787396; 18923149; 27631493 9 31 5 regulates kinetochore localization of TTK; kinetochore localization -SIRT6 SIRT6 DEACETYLASE; DEUBIQUITINASE; Deacetylase; EC 2.4.2.31; EC 3.5.1.-; Transferase Q8N6T7 51548 19p13.3 human S338-p 7916000 PKRERPTsPAPHRPP protein degradation; molecular association, regulation; intracellular localization; phosphorylation DNA repair, induced; carcinogenesis, induced; cell growth, induced; apoptosis, inhibited NUP88(INDUCES); NUP155(INDUCES); NUP85(INDUCES); NUP214(INDUCES); NUP35(INDUCES) 24163442; 25074979; 34359939 3 7 23 regulates phosphorylation of ATM and CHK2, confers resistance to doxorubicin -MLH1 MLH1 Cell cycle regulation; DNA repair, damage; Tumor suppressor P40692 4292 3p22.2 human K361-ub 1878089101 GPSGEMVkSTTSLTS molecular association, regulation MSH2(INDUCES); MSH6(INDUCES) 30770470 1 1 0 -PRKDC DNAPK DNA repair, damage; EC 2.7.11.1; KINASE; Kinase, protein; Nucleolus; Protein kinase, Ser/Thr (non-receptor); Protein kinase, atypical P78527 5591 8q11.21 human T3950-p 473573 GHAFGSAtQFLPVPE PI3_PI4_kinase intracellular localization; enzymatic activity, inhibited cell cycle regulation 17158925; 24844881 2 1 0 -CTTN Cortactin Actin-binding; Cytoskeletal; Motility/polarity/chemotaxis Q14247 2017 11q13.3 human Y446-p 448776 GTEPEPVySMEAADY protein degradation; molecular association, regulation; intracellular localization cell growth, induced; apoptosis, inhibited PTP1B(INDUCES) 18387954; 27363897 3 36 867 p21Cip1 degradation and nuclear export, HASMC proliferation; potentiates apoptosis during prolonged hyperosmotic stress -SLC6A12 SLC6A12 Membrane protein, integral; Membrane protein, multi-pass; Transporter; Transporter, SLC family P27799 404013 dog T40-p 33673901 VKDRGQWtNKMEFVL SNF activity, induced; intracellular localization 24829506 1 0 0 important for trafficking and insertion of SLC6A12 in the plasma membrane -Ncoa1 SRC-1 ACETYLTRANSFERASE; Acetyltransferase; DNA-binding; EC 2.3.1.48; Nuclear receptor co-regulator; Oncoprotein; Transcription, coactivator/corepressor P70365 17977 12|12 A1.1 mouse S1271-p 396518803 MPVPPPQsSLLQQTP DUF1518 molecular association, regulation cell differentiation, induced; transcription, induced RORC(INDUCES) 29282318 1 1 0 -Cebpb C/EBP-beta DNA-binding; Motility/polarity/chemotaxis; Transcription factor P21272 24253 3q42 rat S111-p 13373504 PSDYGYVsLGRAGAK molecular association, regulation cell growth, induced; transcription, induced DNA(INDUCES) 20351173 1 3 1 -BAD BAD Apoptosis Q92934 572 11q13.1 human S124-p 9938302 MSDEFVDsFKKGLPR Bcl-2_BAD apoptosis, inhibited 21317286 1 4 0 -Kif23 KIF23 Microtubule-binding; Motility/polarity/chemotaxis; Motor E9Q5G3 71819 9|9 B mouse S805-p 2902205 IPVRHRRsRSAGSRW MKLP1_Arf_bdg intracellular localization cell cycle regulation; cytoskeletal reorganization 15199097 5 1 0 regulates cytokinesis -PDGFRB PDGFRB EC 2.7.10.1; KINASE; Kinase, protein; Membrane protein, integral; Oncoprotein; Protein kinase, TK; Protein kinase, tyrosine (receptor) P09619 5159 5q32 human Y857-p 447509 DIMRDSNyISKGSTF PK_Tyr_Ser-Thr phosphorylation; enzymatic activity, induced cell differentiation, inhibited; carcinogenesis, induced; cell motility, induced; cell growth, induced; signaling pathway regulation; cell growth, altered 20494825; 34858182; 35393545 17 2 3 regulates the phosphorylation of DUSP1/p38MAPK and inhibits cell differentiation through the DUSP1/p38MAPK pathway -PRKCD PKCD EC 2.7.11.13; KINASE; Kinase, protein; Nuclear receptor co-regulator; Protein kinase, AGC; Protein kinase, Ser/Thr (non-receptor); Protein kinase, tyrosine (non-receptor); Tumor suppressor Q05655 5580 3p21.1 human Y155-p 447575 IKQAKIHyIKNHEFI intracellular localization apoptosis, induced 28237688 11 0 0 -PAK1 PAK1 EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, STE; Protein kinase, Ser/Thr (non-receptor) Q13153 5058 11q13.5-q14.1 human S174-p 7320951 TPAVPPVsEDEDDDD molecular association, regulation; enzymatic activity, induced cell cycle regulation DYNLL2(INDUCES) 19520772 2 24 6 important for mitotic progression -Vim Vimentin Cytoskeletal; Motility/polarity/chemotaxis P20152 22352 2 A1|2 10.04 cM mouse S7-p 455449 _MSTRSVsSSSYRRM Filament_head molecular association, regulation endocytosis, induced; cytoskeletal reorganization JAG1(INDUCES) 12458200; 28533359 8 21 1 transendocytosis -Pdpk1 PDK1 EC 2.7.11.1; KINASE; Kinase, protein; Nuclear receptor co-regulator; Protein kinase, AGC; Protein kinase, Ser/Thr (non-receptor) Q9Z2A0 18607 17|17 A3.3 mouse S504-p 5938008 LKGEIPWsQELRPEA PH_3 enzymatic activity, inhibited 19047061 1 1 0 -FNIP1 FNIP1 Q8TF40 96459 5q31.1 human S939-p 17550026 DIPRNESsDSALGDS protein stabilization; molecular association, regulation signaling pathway regulation HSP90A(INDUCES) DNA(INDUCES) 30699359 1 2 0 -Akt1 Akt1 EC 2.7.11.1; KINASE; Kinase, protein; Oncoprotein; Protein kinase, AGC; Protein kinase, Ser/Thr (non-receptor) P31750 11651 12 F1|12 61.2 cM mouse S473-gl 4261200 RPHFPQFsYSASGTA Pkinase_C apoptosis, altered 18570920 5 0 0 -ADRB2 ADRB2 GPCR, family 1; Membrane protein, integral; Membrane protein, multi-pass; Receptor, GPCR P07550 154 5q32 human S261-p 447908 TGHGLRRsSKFCLKE 7tm_1 receptor desensitization, inhibited 9461522 9 2 0 like wild type mutant acted in a dominant positive fashion -RBL2 Rb-like 2 Transcription, coactivator/corepressor; Tumor suppressor Q08999 5934 16q12.2 human T642-p 449727 CIAGSPLtPRRVTEV molecular association, regulation cell cycle regulation E2F4(DISRUPTS) 11157749 3 20 44 -APC APC Motility/polarity/chemotaxis; Tumor suppressor P25054 324 5q22.2 human S1510-p 999606 SSSLSALsLDEPFIQ phosphorylation 17910481 1 0 0 phosphorylation by CK1 primes for S1501 phosphorylation by GSK3 -Scarb1 SCARB1 Membrane protein, integral; Membrane protein, multi-pass; Receptor, misc. P97943 25073 12q15 rat S496-p 14567809 AYSESLMsPAAKGTV intracellular localization 26567857 1 3 0 cAMP stimulated selective HDL-CE uptake, SCARB1-mediated and HDL-supported steroid production, nuclear localization to cytoplasm after cAMP stimulation -SYT6 SYT6 Membrane protein, integral; Vesicle Q5T7P8 148281 1p13.2 human T417-p 456500 RRLKKKKtTIKKNTL C2 activity, induced 16111671 1 0 0 -H2AZ1 H2AZ DNA-binding P0C0S5 3015 4q23 human K7-ac 458910 _AGGKAGkDSGKAKT Histone molecular association, regulation transcription, induced FALZ(INDUCES) 32356653 4 14 419 K7ac preferentially engaging the binding site, acetylation at K7ac and K13ac is also the highest-affinity acetylation pattern of isoform I -PACSIN1 PACSIN1 Adaptor/scaffold Q9BY11 29993 6p21.31 human S348-p 4730482 AGDRGSVsSYDRGQP molecular association, regulation PICK1(DISRUPTS) 23918399 1 1 0 regulates AMPAR trafficking -MYBL2 B-Myb DNA-binding; Motility/polarity/chemotaxis; Transcription factor P10244 4605 20q13.12 human T518-p 450111 SMDNTPHtPTPFKNA Cmyb_C molecular association, regulation; protein conformation transcription, induced DNA(INDUCES) 35926712 2 6 20 -APP APP Apoptosis; Cell surface; Membrane protein, integral; Receptor, misc.; Transcription factor P05067 351 21q21.3 human K134-ac 1880082600 LLVPDKCkFLHQERM intracellular localization 35830807 1 1 0 AK7 ameliorates cognitive deficits in APP/PS1 mice via inhibition of K132/134 acetylation; APP acetylation is neuroprotective in cultured hippocampal neurons; APP localization at the cell surface -Tek TIE2 EC 2.7.10.1; KINASE; Kinase, protein; Membrane protein, integral; Protein kinase, TK; Protein kinase, tyrosine (receptor) Q02858 21687 4 C5|4 43.34 cM mouse Y1106-p 448372 TYVNTTLyEKFTYAG molecular association, regulation; phosphorylation cell motility, altered DOK2(INDUCES) 12665569 4 0 1 Mutation of Y1106F reduces tyrosine phosphorylation on Dok-R (Dok2). Mutation prevents Ang1-MH-induced chemotaxis (cannot rescue the null). -AGR2 AGR2 Oncoprotein; Secreted; Secreted, signal peptide O95994 10551 7p21.1 human K89-ub 1877589400 PHSQALKkVFAENKE Thioredoxin_7 protein degradation autophagy, induced; transcription, inhibited 30647455 1 0 0 -Myl12b MRLC2 Contractile Q3THE2 67938 17|17 E1.3 mouse T19-p 448596 KKRPQRAtSNVFAMF apoptosis, inhibited 11485996 36 50 282 -Fam13a FAM13A1 GAP; GAP, Rac/Rho Q8BGI4 58909 6|6 B3 mouse S322-p 3178045 FMRRRSSsLGSYDDE molecular association, regulation; intracellular localization 14-3-3 epsilon(INDUCES) 25609086 1 4 1 -Arhgef2 ARHGEF2 GEF; GEF, Rac/Rho; Motility/polarity/chemotaxis Q60875 16800 3|3 F1 mouse T114-p 12473200 SVSLRSKtTTRERPT molecular association, regulation; activity, inhibited cytoskeletal reorganization DYNLT1(DISRUPTS); 14-3-3 eta(INDUCES) 19667072 1 0 0 14-3-3 and DYNLT1 biind ARHGEF2 in a mutually exclusive manner. -BECN1 beclin 1 Adaptor/scaffold; Autophagy; Membrane protein, peripheral Q14457 8678 17q21.31 human T57-p 4275031 AQAKPGEtQEEETNS autophagy, induced 31260798 2 2 0 -NCOA3 SRC-3 ACETYLTRANSFERASE; Acetyltransferase; EC 2.3.1.48; Motility/polarity/chemotaxis; Nuclear receptor co-regulator; Transcription, coactivator/corepressor Q9Y6Q9 8202 20q13.12 human K723-sm 3817001 CGDGNVVkQEQLSPK DUF4927 transcription, inhibited 16760465 1 0 0 -MEF2A MEF2A DNA-binding; Motility/polarity/chemotaxis; Transcription factor Q02078 4205 15q26.3 human S408-p 449949 SIKSEPIsPPRDRMT acetylation cell differentiation, inhibited; transcription, induced; transcription, altered 12691662; 15340086; 16484498 3 19 0 switch from sumoylation to acetylsation -IQGAP1 IQGAP1 GAP; GAP, Ras; Motility/polarity/chemotaxis P46940 8826 15q26.1 human Y1510-p 450791 LVKLQQTyAALNSKA RasGAP_C activity, induced; phosphorylation cell motility, inhibited 33087447 1 28 912 Akt activation -PELI1 PELI1 Adaptor/scaffold; EC 6.3.2.-; EC 6.3.2.19; Ligase; UBIQUITIN LIGASE; Ubiquitin conjugating system; Ubiquitin ligase Q96FA3 57162 2p14 human Y154-p 3800785 PPFTARIyAAGFDSS Pellino ubiquitination; phosphorylation; enzymatic activity, induced carcinogenesis, induced; cell motility, induced 36841821 1 1 1 -GATA4 GATA4 Motility/polarity/chemotaxis; Transcription factor P43694 2626 8p23.1 human S105-p 449604 AYTPPPVsPRFSFPG GATA-N protein degradation cell differentiation, inhibited; cell growth, induced 21447557 16 0 0 -ING1 ING1 iso2 Tumor suppressor Q9UK53-2 3621 13q34 human S126-p 484008 LGDTAGNsGKAGADR molecular association, regulation; protein stabilization cell growth, inhibited NQO1(INDUCES) 17585055; 18388957 2 0 0 -Rims1 RIMS1 Adaptor/scaffold; Vesicle Q9JIR4 84556 9q13 rat S287-p 455664 KQASRSRsEPPRERK molecular association, regulation 14-3-3 beta(INDUCES); 14-3-3 gamma(INDUCES); 14-3-3 eta(INDUCES) 12871946 2 1 0 -STXBP5L STXBP5L Q9Y2K9 9515 3q13.33 human S763-p 17433705 CTSPTSQsCSSGKRL protein degradation 25002582 1 2 0 ; in a multiple residue S->D mutant -Fyb1 SLAP-130 Adaptor/scaffold O35601 23880 15|15 A1 mouse Y807-p 449430 VDNDGEIyDDIADGC hSH3 molecular association, regulation Src iso1(INDUCES) 16020549 4 3 68 -PRKD2 PRKD2 EC 2.7.11.13; KINASE; Kinase, protein; Motility/polarity/chemotaxis; Protein kinase, CAMK; Protein kinase, Ser/Thr (non-receptor) Q9BZL6 25865 19q13.32 human S244-p 1028300 SSSSSSAsSYTGRPI molecular association, regulation; intracellular localization transcription, induced; signaling pathway regulation Exportin-1(DISRUPTS); 14-3-3 eta(DISRUPTS) 17962809 1 1 1 -DAAM1 DAAM1 Adaptor/scaffold; Motility/polarity/chemotaxis Q9Y4D1 23002 14q23.1 human Y652-p 7791229 LERTFSAyQRQQDFF FH2 molecular association, regulation carcinogenesis, induced; cell motility, induced; cytoskeletal reorganization DAAM1(INDUCES) 31406243 1 1 3 -H2bc15 H2B DNA-binding P10853 319187 13|13 A3.1 mouse S14-p 449904 APAPKKGsKKAVTKA Histone phosphorylation apoptosis, altered 15361883; 16039583 10 1 0 -STAT1 STAT1 DNA-binding; Transcription factor P42224 6772 2q32.2 human T387-p 1870810800 FNILGTHtKVMNMEE STAT_bind intracellular localization; phosphorylation transcription, altered DNA(DISRUPTS) 33096415 1 0 0 increased level of Tyr phosphorylation in T387A muatnt; DNA binding activity increased in T387A mutant -RPS6KB1 p70S6K iso2 EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, AGC; Protein kinase, Ser/Thr (non-receptor); Translation P23443-2 6198 17q23.1 human S429-p 471897 PVSPVKFsPGDFWGR protein conformation 30612880 2 23 76 -EPAS1 HIF2A DNA-binding; Transcription factor Q99814 2034 2p21 human S581-p 1874020206 LAPVAPHsPFLLDKF transcription, altered 34285132 2 0 0 -SNX8 SNX8 Q9Y5X2 29886 7p22.3 human Y126-p 348335701 MLLHKFPyRMVPALP PX molecular association, regulation transcription, induced IKKB(INDUCES) 29180417 1 0 0 -Jun Jun Oncoprotein; Transcription factor P05627 16476 4 C5|4 43.34 cM mouse T93-p 450449 GHITTTPtPTQFLCP Jun molecular association, regulation NPM1(INDUCES); p14ARF(INDUCES) 18316603 9 3 0 -Eif4b EIF4B RNA-binding; Translation; Translation initiation Q8BGD9 75705 15|15 F2 mouse S422-p 451290 RERSRTGsESSQTGA translation, altered 18836482 11 54 482 -CEBPB C/EBP-beta DNA-binding; Motility/polarity/chemotaxis; Transcription factor P17676 1051 20q13.13 human S76-p 456166 HERAIDFsPYLEPLG phosphorylation transcription, induced 20730378; 23782693 8 0 1 -Adrb2 ADRB2 GPCR, family 1; Membrane protein, integral; Membrane protein, multi-pass; Receptor, GPCR P18762 11555 18 E1|18 35.1 cM mouse S356-p 458917 TYGNGYSsNSNGRTD receptor internalization, induced; receptor internalization, altered cell motility, induced; signaling pathway regulation 18056263; 25460042; 27541735; 31088898 27 2 0 IRS2 is required for ADRB2 internalization; B-arrestin mediated signaling; internalization and the contraction response -Mecp2 MECP2 Transcription, coactivator/corepressor Q00566 29386 Xq37 rat S421-p 470075 EKMPRAGsLESDGCP activity, induced; molecular association, regulation cell differentiation, altered; transcription, induced; translation, inhibited DGCR8(DISRUPTS) 17046689; 33963280 15 13 0 CMW-induced increase in miR101a expression, decrease in Twf1 protein expression and production of CPA behavior -CD44 CD44 iso2 Cell adhesion; Membrane protein, integral; Motility/polarity/chemotaxis; Receptor, misc. P15379-2 12505 2 E2|2 54.13 cM mouse S327-p 450988 LNGEASKsQEMVHLV cell adhesion, induced 7528778 12 58 37 hyaluronate binding is diminished when this residue is mutated -TPX2 TPX2 Cell cycle regulation; Microtubule-binding Q9ULW0 22974 20q11.21 human S125-p 459997 QRRSLRLsAQKDLEQ molecular association, regulation cell cycle regulation CLASP1(INDUCES) 26240182 2 22 17 required for normal spindle length -CYFIP2 CYFIP2 iso2 Cell adhesion; Motility/polarity/chemotaxis Q96F07-2 26999 5q33.3 human T1067-p 4726011 PLIERLGtPQQIAIA FragX_IP cytoskeletal reorganization 28692454 1 12 0 stubby spine density and neurite outgrowth -Lyn LYN EC 2.7.10.2; KINASE; Kinase, protein; Oncoprotein; Protein kinase, TK; Protein kinase, tyrosine (non-receptor) P25911 17096 4 A1|4 2.05 cM mouse Y194-p 454856 SLDNGGYyISPRITF SH2 molecular association, regulation 25587033 2 30 528 Lyn SH2 at Y194 results in only a modest reduction in phospho-peptide binding affinity -Carm1 CARM1 EC 2.1.1.125; METHYLTRANSFERASE; Methyltransferase; Methyltransferase, protein arginine; Nuclear receptor co-regulator Q9WVG6 59035 9|9 A3 mouse T132-p 125971700 LKTCRGHtLERSVFS CARM1 protein stabilization 28637674 1 0 0 -HMGCR HMGCR EC 1.1.1.34; Endoplasmic reticulum; Membrane protein, integral; Membrane protein, multi-pass; Motility/polarity/chemotaxis; Oxidoreductase; Secondary Metabolites Metabolism - terpenoid backbone biosynthesis P04035 3156 5q13.3 human K89-ub 55607400 NLRQLGSkYILGIAG Sterol-sensing protein degradation; ubiquitination 31323021 2 0 0 mutationsdid not reduce sterol-induced degradation of HMGCR, Ubiad1 (WT) or Ubiad1 (G184R) did not increase the amount of mutant HMGCR (K89R, K248R) -SDCBP syntenin Adaptor/scaffold; Cell adhesion; Cytokine; Membrane protein, integral; Motility/polarity/chemotaxis; Vesicle O00560 6386 8q12.1 human S6-p 4148819 __MSLYPsLEDLKVD molecular association, regulation ubiquitin(DISRUPTS) 21949238 2 18 0 -SFN 14-3-3 sigma Adaptor/scaffold P31947 2810 1p36.11 human S74-p 454997 QKSNEEGsEEKGPEV 14-3-3 molecular association, regulation; phosphorylation carcinogenesis, induced; cell growth, induced; transcription, induced; signaling pathway regulation SMAD3(INDUCES); p53(DISRUPTS) DNA(INDUCES) 23741479 2 7 0 Regulates stemness and radioresistance in breast cancer cells; increase phosphorylation of P53 at S15 by mutation of site S74 (S74A) and regulates transcription of P21; TGFb/Smad3 and p53/21 signaling pathways -NRIP1 RIP140 Nuclear receptor co-regulator; Transcription, coactivator/corepressor P48552 8204 21q11.2-q21.1 human R239-m1 2363402 EPLSCAArLQAVASM NRIP1_repr_1 molecular association, regulation; intracellular localization transcription, induced Exportin-1(INDUCES); HDAC3(DISRUPTS) DNA(DISRUPTS) 17053781 2 2 0 -Cebpb C/EBP-beta DNA-binding; Motility/polarity/chemotaxis; Transcription factor P28033 12608 2 H3|2 87.58 cM mouse K216-ac 458940 PAKAKAKkTVDKLSD molecular association, regulation transcription, inhibited DNA(DISRUPTS) 22865229 4 1 0 -DVL3 DVL3 Motility/polarity/chemotaxis Q92997 1857 3q27.1 human S611-p 34668129 ESDHTTRsSLRGPRE Dsh_C intracellular localization 24993822 1 1 0 -Mkln1 MKLN1 Cell adhesion; Motility/polarity/chemotaxis O89050 27418 6|6 A3.3 mouse T515-p 474505 MVPMTGFtQRATIDP molecular association, regulation MKLN1(INDUCES) 17049906 1 0 0 mutation inhibited MKLN1 self-association -SND1 SND1 RNA-binding; Transcription, coactivator/corepressor Q7KZF4 27044 7q32.1 human S426-p 3203808 VDYIRPAsPATETVP SNase cell cycle regulation; transcription, induced 25627688 2 39 10 gene transcriptional activation of cyclin A and E2F-1 -PDE4D PDE4D iso6 EC 3.1.4.53; Nucleotide Metabolism - purine; Phosphodiesterase Q08499-6 5144 5q11.2-q12.1 human K78-ub 7388018 LLSSNIPkQRRFTVA molecular association, regulation RACK1(DISRUPTS); ARRB1(INDUCES) 19372219 1 0 0 -Cttn Cortactin Actin-binding; Cytoskeletal; Motility/polarity/chemotaxis Q60598 13043 7|7 F5 mouse S417-p 465632 PIEDRPPsSPIYEDA cell cycle regulation; cell motility, altered 18515860 1 43 55 -Map2 MAP2 iso3 Cytoskeletal; Motility/polarity/chemotaxis P15146-3 25595 9q32 rat K369-ac 62495505 RVKIESVkLDFKEKA Tubulin-binding cytoskeletal reorganization 28002468 1 1 0 -AR AR DNA-binding; Nuclear receptor; Transcription factor P10275 367 Xq12 human K846-ub 7911901 LDRIIACkRKNPTSC Hormone_recep protein degradation; molecular association, regulation; ubiquitination; intracellular localization transcription, induced RNF14(INDUCES) DNA(INDUCES) 19345326; 31620784; 35163481 5 1 0 required for ubiquitination at K848 -ETS1 Ets-1 DNA-binding; Motility/polarity/chemotaxis; Oncoprotein; Transcription factor P14921 2113 11q24.3 human T38-p 447950 CADVPLLtPSSKEMM activity, induced; protein stabilization; molecular association, regulation; ubiquitination carcinogenesis, induced; cell growth, inhibited; cell differentiation, induced; apoptosis, inhibited; transcription, induced; transcription, altered; cell growth, altered HUWE1(DISRUPTS) 12048211; 21441955; 32131547; 34900980; 8552081; 8761310 14 4 5 Substitution of T38A enhances Ets-1 rescue of CSFR defective receptor (Y809F). ; inhibits ubiquitination -Tgif1 TGIF DNA-binding; Nuclear receptor co-regulator; Transcription, coactivator/corepressor P70284 21815 17|17 E1.3 mouse K130-ub 40212806 IEAAMGIkNFMPTLE protein degradation carcinogenesis, inhibited; cell growth, inhibited 23911286 1 0 0 -Tp53 p53 Activator; DNA-binding; Motility/polarity/chemotaxis; Nuclear receptor co-regulator; Transcription factor; Tumor suppressor P02340 22059 11 B3|11 42.83 cM mouse K98-ac 59149204 SSFVPSQkTYQGNYG P53 cell cycle regulation; carcinogenesis, inhibited; apoptosis, induced 33303641 2 1 0 senescence, ferroptosis, failed to develop early-onset tumors -NREP P311 Motility/polarity/chemotaxis Q16612 9315 5q22.1 human S59-p 457551 LGSSELRsPRISYLH Alveol-reg_P311 protein degradation cell motility, altered; cell adhesion, altered 16229809 1 0 0 P311 S59D and S59E mutants fail to activate Rac1 GTPase -ESR1 ER-alpha DNA-binding; Nuclear receptor; Transcription factor P03372 2099 6q25.1-q25.2 human S46-p 12127401 LGEVYLDsSKPAVYN Oest_recep activity, induced transcription, altered 20043841 1 0 0 -Nsf NSF Adaptor/scaffold; Autophagy; EC 3.6.4.6; Protease; Vesicle P46460 18195 11 E1|11 67.54 cM mouse S569-p 460358 FPFIKICsPDKMIGF AAA molecular association, regulation exocytosis, altered NSF(INDUCES) 16461345 1 2 4 inhibits oligomerization, modulates exocytosis -Atf4 ATF-4 DNA-binding; Transcription factor Q06507 11911 15 E1|15 37.85 cM mouse S251-p 451447 NLPSPGGsRGSPRPK activity, induced cell growth, altered 15109498 1 0 0 -Mybpc3 MYBPC3 Myosin-binding P56741 295929 3q24 rat S279-p 471079 RSAFRRTsLAGTGRR cytoskeletal reorganization 35288601 25 9 14 -SMAD2 SMAD2 DNA-binding; Transcription factor Q15796 4087 18q21.1 human S245-p 448794 NQSMDTGsPAELSPT activity, induced; protein stabilization; molecular association, regulation; intracellular localization; protein conformation cell differentiation, induced; cell motility, altered; transcription, induced SETD2(INDUCES); SMAD4(INDUCES) RNA(INDUCES) 10197981; 12193595; 19115199; 27153775; 31995604; 34504019 12 0 0 -NFE2 NF-E2 Cytoskeletal; DNA-binding; Transcription factor Q16621 4778 12q13.13 human K215-ub 11489904 SSGPVRAkPTARGEA protein degradation; ubiquitination transcription, inhibited 19966288 1 0 0 -Gprc5b GPRC5B GPCR, family 3; Membrane protein, integral; Membrane protein, multi-pass; Receptor, GPCR Q923Z0 64297 7|7 F2 mouse Y383-p 462507 APFRSNVyQPTEMAV molecular association, regulation; phosphorylation signaling pathway regulation Fyn(INDUCES) 23169819 1 9 106 induces phosphorylation of Caveolin1 and induces abundance of IKKE, and IKKE-NF-KB signaling ; induces phosphorylation of Cav1 and inflammatory signaling in adipose tissue -Brsk2 BRSK2 EC 2.7.11.1; EC 2.7.11.26; KINASE; Kinase, protein; Protein kinase, CAMK; Protein kinase, Ser/Thr (non-receptor) Q69Z98 75770 7|7 F5 mouse S428-p 4734873 LSTSPLSsPRVTPHP protein stabilization; enzymatic activity, inhibited; phosphorylation 23790753 1 8 1 inhibits axon branching (activated in BRSK2 18A mutant) -RHOA RHOA G protein; G protein, monomeric; G protein, monomeric, Rho; Motility/polarity/chemotaxis; Oncoprotein P61586 387 3p21.31 human K135-ub 486702 RRELAKMkQEPVKPE Ras protein degradation 23871831 1 9 99 -DARS1 DARS Aminoacyl-tRNA synthetase; EC 6.1.1.12; Ligase; Translation; Translation regulation P14868 1615 2q21.3 human S146-p 18008485 VQKIYVIsLAEPRLP protein conformation 23609930 0 2 0 -Mlkl MLKL KINASE; Kinase, protein; Protein kinase, Ser/Thr (non-receptor); Protein kinase, TKL Q9D2Y4 74568 8|8 E1 mouse S345-p 22996309 ELSKTQNsISRTAKS PK_Tyr_Ser-Thr activity, induced; molecular association, regulation; intracellular localization; protein conformation apoptosis, induced; signaling pathway regulation MLKL(INDUCES) 26024392; 30442947; 31748744; 32094226; 33221042; 34239062; 34782457 36 3 0 -CAV2 caveolin-2 Adaptor/scaffold; Motility/polarity/chemotaxis P51636 858 7q31.2 human S135-p 2765000 SVQTIWKsVTDVIIA Caveolin activity, induced 12743374 1 0 0 formation of caveolae -LDHA LDH-A Amino Acid Metabolism - cysteine and methionine; Apoptosis; Carbohydrate Metabolism - glycolysis and gluconeogenesis; Carbohydrate Metabolism - propanoate; Carbohydrate Metabolism - pyruvate; EC 1.1.1.27; Oxidoreductase P00338 3939 11p15.1 human Y83-p 3780568 KIVSGKDyNVTANSK Ldh_1_N enzymatic activity, induced 21969607 1 1 8 -TRPM2 TRPM2 iso3 Channel, calcium; EC 3.6.1.13; Hydrolase; Membrane protein, integral; Membrane protein, multi-pass; Transporter O94759-3 7226 21q22.3 human S39-p 30312508 NLRRSNSsLFKSWRL apoptosis, induced 24337049 1 0 0 induces Ca2+ entry and apoptosis -KRT19 K19 Cytoskeletal P08727 3880 17q21.2 human K208-sm 25027604 EMQIEGLkEELAYLK Filament cytoskeletal reorganization 21062750 1 0 0 sumoylation regulate solubility; modified by poly-SUMO-2/3 chains, oxidative stress, apoptosis, and/or phosphatase inhibition increase sumoylation in primary hepatocytes; K to R mutants show filament disorganization -HDAC6 HDAC6 DEACETYLASE; Deacetylase; EC 3.5.1.98; Nuclear receptor co-regulator; Ubiquitin conjugating system Q9UBN7 10013 Xp11.23 human S43-p 4759159 KKGAVPRsIPNLAEV molecular association, regulation cell motility, induced PIN1(INDUCES) 30443180 1 3 0 nteraction of HDAC6 with Pin1 mediates cell motility -SP1 SP1 C2H2-type zinc finger protein; DNA-binding; Transcription factor P08047 6667 12q13.13 human S698-gl 5262506 CPKRFMRsDHLSKHI zf-C2H2 transcription, induced 18513490 2 1 0 -Trim71 TRIM71 UBIQUITIN LIGASE; Ubiquitin conjugating system; Ubiquitin ligase Q1PSW8 636931 9|9 F3 mouse S3-p 18914372 _____MAsFPETDFQ protein stabilization; molecular association, regulation; ubiquitination carcinogenesis, inhibited UBE1(DISRUPTS); UBE2D3(DISRUPTS); ubiquitin(DISRUPTS) 31160797 1 2 0 inhibits ubiquitination -CALR Calreticulin ACETYLTRANSFERASE; Acetyltransferase; Calcium-binding; Motility/polarity/chemotaxis; Nuclear receptor co-regulator; Secreted; Secreted, signal peptide P27797 811 19p13.13 human K206-ac 4219812 DWDFLPPkKIKDPDA Calreticulin protein conformation 18795239 1 2 0 -GSK3B GSK3B EC 2.7.11.1; EC 2.7.11.26; KINASE; Kinase, protein; Protein kinase, CMGC; Protein kinase, Ser/Thr (non-receptor) P49841 2932 3q13.33 human K86-ub 1870957200 GELVAIKkVLQDKRF Pkinase activity, inhibited 30711629 0 1 0 -SIRT6 SIRT6 DEACETYLASE; DEUBIQUITINASE; Deacetylase; EC 2.4.2.31; EC 3.5.1.-; Transferase Q8N6T7 51548 19p13.3 human K128-ub 573777002 RSGFPRDkLAELHGN SIR2 protein degradation carcinogenesis, induced 33903120 1 1 0 -Polr2a POLR2A EC 2.7.7.48; EC 2.7.7.6; Nucleotide Metabolism - purine; Nucleotide Metabolism - pyrimidine; Transcription initiation complex; Transferase P08775 20020 11 B3|11 42.86 cM mouse K1873-ub 2134720 KYSPTSPkYSPTSPT RNA_pol_Rpb1_R protein degradation 17526739 1 1 0 -H2AX H2AX DNA repair, damage; DNA-binding; Helicase P16104 3014 11q23.3 human K5-ac 482536 ___SGRGkTGGKARA Histone ADP-ribosylation; intracellular localization; phosphorylation DNA repair, induced 19895790; 26438602; 26976643 5 3 63 induces ribosylation of PARP1 -CDH1 CDH1 Cell adhesion; Membrane protein, integral; Motility/polarity/chemotaxis; UBIQUITIN LIGASE; Ubiquitin ligase P12830 999 16q22.1 human T790-p 55578700 TRNDVAPtLMSVPRY molecular association, regulation; activity, inhibited CTNNB1(DISRUPTS); CBLL1(DISRUPTS) 27203386 1 0 0 impairs homophilic interaction at cell-cell contacts -SMARCAL1 SMARCAL1 EC 3.6.1.-; EC 3.6.4.-; Helicase Q9NZC9 50485 2q35 human S173-p 29606709 PLAKPKSsQETPAHS protein degradation 30996091 1 2 0 -E2F1 E2F1 DNA-binding; Transcription factor Q01094 1869 20q11.22 human S403-p 447870 PEEFISLsPPHEALD protein degradation; molecular association, regulation; ubiquitination; intracellular localization; protein conformation cell cycle regulation; cell differentiation, altered; transcription, altered; cell growth, altered PRB1(INDUCES) 10428966; 18794805; 20447425; 20616879; 27903963 7 0 0 regulation of cell transformation efficiency, target gene expression altered -ADRB2 ADRB2 GPCR, family 1; Membrane protein, integral; Membrane protein, multi-pass; Receptor, GPCR P07550 154 5q32 human S407-p 457443 DSQGRNCsTNDSLL_ protein conformation 21868357 4 1 0 -POLB POLB DNA repair, damage; DNA replication; EC 2.7.7.7; Lyase; Transferase P06746 5423 8p11.21 human K206-ub 56841101 SFTSESTkQPKLLHQ DNA_pol_B_palm protein degradation; ubiquitination 25423885 1 0 0 -NDUFA9 NUEM EC 1.6.5.3; EC 1.6.99.3; Energy Metabolism - oxidative phosphorylation; Mitochondrial; Oxidoreductase Q16795 4704 12p13.32 human K189-ac 33351156 RNKAVGEkVVRDAFP Epimerase activity, inhibited 27508876 1 3 0 inhibits Complex 1 activity -Irx3 IRX3 DNA-binding P81067 16373 8 C5|8 44.55 cM mouse K409-ub 1874748508 LVSAPLGkFPAWTNR protein degradation transcription, inhibited 34556885 1 0 0 -PPP1R1A PPP1R1A Inhibitor; Protein phosphatase, regulatory subunit Q13522 5502 12q13.2 human T75-p 471085 PRQRKKMtRITPTMK DARPP-32 phosphorylation; enzymatic activity, induced cytoskeletal reorganization 17046826; 17416610 2 0 0 decreased contractility, and decreased PLB phosphorylation in PPP1R1A S67D and T75D mutants; Phosphorylation of PPP1R1A at T75 induces PP1 activity in isolated myocytes and in vitro. Phosphorylation of T75 significantly depresses myocyte contractility, by reducing cardiac contractility by reducing Ca2+ affinity of SERCA2a. -KCNN1 KCNN1 Membrane protein, integral; Membrane protein, multi-pass Q92952 3780 19p13.11 human Y109-p 17436177 KRKRLSDyALIFGMF SK_channel activity, induced 23496660 1 1 1 -FBP1 FBPase Carbohydrate Metabolism - fructose and mannose; Carbohydrate Metabolism - glycolysis and gluconeogenesis; Carbohydrate Metabolism - pentose phosphate pathway; EC 3.1.3.11; Mitochondrial; Phosphatase (non-protein) P09467 2203 9q22.32 human K110-ac 1876844501 AIIVEPEkRGKYVVC FBPase molecular association, regulation carcinogenesis, inhibited; transcription, inhibited BRD4(INDUCES) 32195024 1 0 0 -Atat1 ATAT1 iso2 ACETYLTRANSFERASE; Acetyltransferase; EC 2.3.1.108 Q8K341-2 73242 17|17 B1 mouse K210-ac 11322008 KRAEGDIkPYSSSDR enzymatic activity, induced 23275437 1 5 0 -GRIN2B NMDAR2B Channel, calcium; Channel, ligand-gated; Membrane protein, integral; Membrane protein, multi-pass Q13224 2904 12p13.1 human S1166-p 481156 SDDFKRDsVSGGGPC NMDAR2_C activity, induced 24431445 3 2 1 NMDAR potentiation and Ca2+ signaling in spines -CD274 PD-L1 Membrane protein, integral Q9NZQ7 29126 9p24.1 human S195-p 796148000 EKLFNVTsTLRINTT C2-set_2 protein degradation; ubiquitination; intracellular localization; N-GlcNAc glycosylation carcinogenesis, inhibited; RNA stability, inhibited; DNA repair, inhibited; signaling pathway regulation 30118680; 35181605 2 1 0 -Map2 MAP2 iso3 Cytoskeletal; Motility/polarity/chemotaxis P15146-3 25595 9q32 rat K273-ac 62495514 PRTPGTPkSGILVPS cytoskeletal reorganization 28002468 1 1 0 -CCDC6 CCDC6 Apoptosis; Cytoskeletal; Oncoprotein Q16204 8030 10q21.2 human T434-p 479429 TPPPSPNtQTPVQPP protein stabilization; molecular association, regulation; intracellular localization apoptosis, altered FBXW7(DISRUPTS) 17420723; 23108047; 24059746 3 0 0 nuclear localization -AKAP8 AKAP8 Adaptor/scaffold; Cell cycle regulation; Mitochondrial; RNA-binding O43823 10270 19p13.12 human Y146-p 40420002 CLPEHNPyRPSYSYD molecular association, regulation 25770215 1 0 0 Phenylalanine mutants inhibited dissociation from nuclear structures; structural chromatin changes -YAP1 YAP1 Oncoprotein; Transcription, coactivator/corepressor P46937 10413 11q22.1 human K494-me 55591500 ESVLAATkLDKESFL molecular association, regulation axin 1(INDUCES) 27046831 2 0 0 -Pdcd1 PD-1 Apoptosis; Membrane protein, integral Q02242 18566 1|1 D mouse Y225-p 50293000 APVPSVAyEELDFQG cell growth, induced 26359984 3 1 0 increased three-dimensional tumor growth -MAPT Tau iso3 ACETYLTRANSFERASE; Acetyltransferase; Cytoskeletal P10636-3 4137 17q21.31 human S279-p 449082 PVVSGDTsPRHLSNV molecular association, regulation cytoskeletal reorganization 10747907 145 54 69 regulates association with membrane -Oprd1 DOR-1 GPCR, family 1; Membrane protein, integral; Membrane protein, multi-pass; Receptor, GPCR P33533 24613 5q36 rat T161-p 455533 VKALDFRtPAKAKLI 7tm_1 molecular association, regulation; intracellular localization MOR-1(INDUCES) 19295160; 22466129 3 0 0 regulates heat and inflammatory hypersensitivity , induces morphine tolerance; involved in morphine antinociceptive tolerance -Cryab CRYAB Chaperone; Heat shock protein P23927 12955 9 A5.3|9 27.75 cM mouse S45-p 448748 FSTATSLsPFYLRPP Crystallin protein degradation; molecular association, regulation; intracellular localization signaling pathway regulation 28196893; 29088822 35 7 1 phosphorylation of this site stimulates interaction with multiple proteins and activates multiple pathways; induces reactive astrogliosis -INSIG2 INSIG2 Endoplasmic reticulum; Membrane protein, integral; Membrane protein, multi-pass; Transcription, coactivator/corepressor Q9Y5U4 51141 2q14.1-q14.2 human S151-p 1868515112 LWWTFDRsRSGFGLG INSIG activity, induced; protein degradation; molecular association, regulation carcinogenesis, induced; cell growth, induced; apoptosis, inhibited; transcription, induced SCAP(INDUCES) 32322062; 33842305 2 1 0 -Prkcb PKCB EC 2.7.11.13; KINASE; Kinase, protein; Motility/polarity/chemotaxis; Protein kinase, AGC; Protein kinase, Ser/Thr (non-receptor) P68403 25023 1q36 rat S661-p 448672 QNEFAGFsYTNPEFV Pkinase_C protein conformation 21215369 12 1 0 -KIT Kit EC 2.7.10.1; KINASE; Kinase, protein; Membrane protein, integral; Oncoprotein; Protein kinase, TK; Protein kinase, tyrosine (receptor) P10721 3815 4q12 human S746-p 450036 RRSVRIGsYIERDVT PK_Tyr_Ser-Thr enzymatic activity, inhibited; phosphorylation 7539802 2 5 0 -Sgo2a SGOL2 Unknown function Q7TSY8 68549 1 C1.3|1 28.86 cM mouse T600-p 89115100 KQKINRRtKIISVMS intracellular localization 28502659 1 0 0 dissociation from chromosome arms -TTK TTK Cancer Testis Antigen (CTA); EC 2.7.12.1; KINASE; Kinase, protein; Protein kinase, Other; Protein kinase, dual-specificity (non-receptor) P33981 7272 6q14.1 human K848-ub 21187452 SHNSSSSkTFEKKRG protein degradation cell cycle regulation 34586601 1 3 0 -TAOK3 TAO3 EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, STE; Protein kinase, Ser/Thr (non-receptor) Q9H2K8 51347 12q24.23 human S324-p 468901 RNGPLNEsQEDEEDS activity, induced cell cycle regulation 17396146 2 52 11 -Nrip1 RIP140 Nuclear receptor co-regulator; Transcription, coactivator/corepressor Q8CBD1 268903 16|16 C3.1 mouse K607-ac 459040 LMDLTKGkESQAEKP NRIP1_repr_2 intracellular localization transcription, inhibited 15879431 0 2 0 -TP53 p53 Activator; DNA-binding; Motility/polarity/chemotaxis; Nuclear receptor co-regulator; Transcription factor; Tumor suppressor P04637 7157 17p13.1 human S149-p 456326 PVQLWVDsTPPPGTR P53 protein degradation; molecular association, regulation; ubiquitination cell cycle regulation; cell growth, inhibited; apoptosis, induced; transcription, induced FBXO42(INDUCES) 21127074 3 0 1 -Dok2 DOK2 Adaptor/scaffold O70469 13449 14 D2|14 36.71 cM mouse Y304-p 448880 PGAPEGEyAVPFDTV molecular association, regulation cell differentiation, altered; cell growth, altered RASA1(INDUCES) 10428862; 10508618; 12093790 3 22 745 -BID BID Apoptosis; Mitochondrial P55957 637 22q11.21 human S67-p 14570494 DGNRSSHsRLGRIEA BID cell cycle regulation; cell differentiation, induced; apoptosis, induced; apoptosis, inhibited 24767991; 36202990 2 5 0 -GHR GH receptor Membrane protein, integral; Receptor, cytokine NP_999419 397488 pig Y627-p 486258 EFLSSCGyVSTDQLN transcription, induced DNA(INDUCES) 8647880 3 0 0 -Akt1s1 PRAS40 Apoptosis Q9D1F4 67605 7|7 B3 mouse T247-p 470067 LPRPRLNtSDFQKLK PRAS phosphorylation 20138985 50 69 781 required for phosphorylation of PRAS40 S184 -Irs1 IRS1 Adaptor/scaffold; Motility/polarity/chemotaxis P35570 25467 9q34 rat S570-p 451681 RLPGYRHsAFVPTHS molecular association, regulation PIK3R1(DISRUPTS) 15134463 4 5 0 -GAB2 GAB2 Adaptor/scaffold Q9UQC2 9846 11q14.1 human Y643-p 450913 TSDEKVDyVQVDKEK molecular association, regulation; phosphorylation cell cycle regulation; transcription, altered SHP-2(INDUCES) 15170389; 18644434; 23980151 4 11 190 activates Erk1/2 and regulates cells proliferation; Binding of SHP-2 activates the MAPK pathway and transcription. -MALT1 MALT1 Adaptor/scaffold; Apoptosis; EC 3.4.22.-; Ligase; Nuclear export; Protease; UBIQUITIN LIGASE; Ubiquitin conjugating system Q9UDY8 10892 18q21.32 human K709-ub 2134708 KQEVNVGkPLIAKLD MALT1_Ig protein degradation; molecular association, regulation IKKA(INDUCES) 17948050 1 1 0 activation of NF-kB pathway and IL-2 induction -H2AC11 H2A.1 DNA-binding P0C0S8 8329 6p22.1 human K119-ub 482913 QAVLLPKkTESHHKA Histone_H2A_C molecular association, regulation; ubiquitination; intracellular localization cell differentiation, inhibited; cell cycle regulation; carcinogenesis, induced; cell motility, induced; cell growth, inhibited; DNA repair, induced; autophagy, induced; chromatin organization, altered; cell growth, induced; cytoskeletal reorganization; transcription, inhibited DNA(INDUCES) 15386022; 15525528; 16702407; 19503595; 19791798; 25578731; 26416890; 26738589; 27716482; 28073915; 30992312; 32427989; 32571933; 33328315; 35346195 48 14 146 BMI1 directly binds to the promoter region of SIK1and promotes monoubiquitination of histone H2A.1K119, and inhibits H3K4me BMI1 inhibits SIK1 increasing proliferation and metastasis -IFITM1 IFITM1 Cell cycle regulation; Membrane protein, integral; Membrane protein, multi-pass P13164 8519 11p15.5 human K122-ub 37045601 MLQIIQEkRGY____ molecular association, regulation; intracellular localization AP3M1(INDUCES); AP3M2(INDUCES) 25527505 1 0 0 mutants K122A, R123A, KR/AA and 4KR+KR/AA, but not K122R and 4KR showed decreased or complete loss of interaction with u3A and u3B; -Regulation of endocytic trafficking and viral entry into the cell -Ralgds RALGDS GEF; GEF, Ras Q03385 19730 2|2 A3 mouse Y752-p 59087905 DVDNGNMyKSILVTS RA molecular association, regulation KRas(DISRUPTS); HRas(DISRUPTS) 27773821 1 1 0 -ALK ALK EC 2.7.10.1; KINASE; Kinase, protein; Membrane protein, integral; Oncoprotein; Protein kinase, TK; Protein kinase, tyrosine (receptor) Q9UM73 238 2p23.2-p23.1 human Y1584-p 450380 FPCGNVNyGYQQQGL molecular association, regulation IRS2(INDUCES) 30459283 0 4 36 -Ptpre PTPRE iso2 EC 3.1.3.48; Membrane protein, integral; Motility/polarity/chemotaxis; PHOSPHATASE; Receptor protein phosphatase, tyrosine P49446-2 19267 7 F3|7 81.27 cM mouse Y638-p 450705 FIDIFSDyANFK___ molecular association, regulation cell adhesion, altered Pyk2(INDUCES); Src(INDUCES) 19692574 4 22 597 -CBLB Cbl-b Adaptor/scaffold; Calcium-binding; EC 6.3.2.-; Ligase; UBIQUITIN LIGASE; Ubiquitin conjugating system; Ubiquitin ligase Q13191 868 3q13.11 human Y709-p 475085 VEEDDDEyKIPSSHP molecular association, regulation CRKL(INDUCES) 10022120 3 6 115 in vitro and vivo; Y709 is major binding site, and to lesser extent Y665 -HMGN1 HMGN1 DNA-binding; Nuclear receptor co-regulator P05114 3150 21q22.2 human K82-ac 458854 PAENGETkTEESPAS HMG14_17 molecular association, regulation DNA(DISRUPTS) 10753971 1 1 0 -IFNAR2 IFNAR2 Membrane protein, integral; Receptor, cytokine P48551 3455 21q22.11 human Y318-p 14574802 KKVWDYNyDDESDSD molecular association, regulation transcription, induced; signaling pathway regulation STAT2(DISRUPTS) 34813358 2 0 0 induces STAT phosphorylation and signaling -ZC3HC1 NIPA Cell cycle regulation; Ubiquitin conjugating system Q86WB0 51530 7q32.2 human S381-p 14576869 RTRPVTRsMGTGDTP molecular association, regulation; intracellular localization cell growth, induced NPM-ALK(DISRUPTS) 31434245 1 9 1 -Pygb PYGB Carbohydrate Metabolism - starch and sucrose; EC 2.4.1.1; Kinase, other; Phosphorylase; Transferase Q8CI94 110078 2 G3|2 74.74 cM mouse S15-p 456885 SERQKQIsVRGIAGL signaling pathway regulation 21668450 4 17 1 regulation of glycogen synthesis via R3F-PP1 signaling in astrocytoma cells -CREBBP CBP ACETYLTRANSFERASE; Acetyltransferase; DNA-binding; EC 2.3.1.48; Motility/polarity/chemotaxis; Nuclear receptor co-regulator; Transcription, coactivator/corepressor Q92793 1387 16p13.3 human R2151-me 1872850902 AMQAGVPrPGVPPQQ molecular association, regulation; acetylation; enzymatic activity, induced RAC3(INDUCES); ER-alpha(INDUCES) DNA(INDUCES) 21632823 1 0 0 induces CBP autoacetylation -TP53 p53 Activator; DNA-binding; Motility/polarity/chemotaxis; Nuclear receptor co-regulator; Transcription factor; Tumor suppressor P04637 7157 17p13.1 human K386-sm 2255102 RHKKLMFkTEGPDSD activity, induced; sumoylation; molecular association, regulation apoptosis, induced; autophagy, inhibited; transcription, inhibited; transcription, altered DNA(DISRUPTS) 10562558; 10788439; 17012228; 19339993; 19838051; 35187108 14 3 0 K386 SUMOylation mediates AOPP-BSA-induced endothelial vascular senescence and apoptosis evasion -DIAPH2 Diaphanous-2 Cytoskeletal; Motility/polarity/chemotaxis O60879 1730 Xq21.33 human K970-ac 63341500 TMHNNMMkLYENLGE FH2 cytoskeletal reorganization 28255013 1 0 0 regulates cytokinesis and erythrocyte enucleation -FOXM1 FOXM1 DNA-binding; Transcription factor Q08050 2305 12p13.33 human S704-p 449265 IDVPKPGsPEPQVSG activity, induced; molecular association, regulation; protein stabilization cell growth, induced; transcription, induced PIN1(INDUCES) 22094256; 26279295 2 6 0 -PRKD2 PRKD2 EC 2.7.11.13; KINASE; Kinase, protein; Motility/polarity/chemotaxis; Protein kinase, CAMK; Protein kinase, Ser/Thr (non-receptor) Q9BZL6 25865 19q13.32 human S706-p 449864 ARIIGEKsFRRSVVG Pkinase molecular association, regulation; enzymatic activity, induced transcription, induced; signaling pathway regulation 14-3-3 eta(INDUCES); Exportin-1(DISRUPTS); 14-3-3 eta(DISRUPTS) 12058027; 17962809 5 10 21 -REPS2 REPS2 Adaptor/scaffold; G protein regulator, misc. Q8NFH8 9185 Xp22.2 human S463-p 480114 RPRSRSYsSTSIEEA molecular association, regulation AP2A1(DISRUPTS) 10764745 1 6 4 Phosphorylation inhibits during mitosis -Irs1 IRS1 Adaptor/scaffold; Motility/polarity/chemotaxis P35570 25467 9q34 rat S357-p 4859802 HAHRHRGsSRLHPPL molecular association, regulation; phosphorylation PKCD(INDUCES) 18285345 2 0 0 leads to reduced phosphorylation of Akt -POLB POLB DNA repair, damage; DNA replication; EC 2.7.7.7; Lyase; Transferase P06746 5423 8p11.21 human K61-ub 12723500 KSGAEAKkLPGVGTK HHH_8 protein degradation DNA repair, inhibited 19713937 1 1 0 -FLI1 FLI1 DNA-binding; Oncoprotein; Transcription factor Q01543 2313 11q24.3 human K334-ub 62489906 KPNMNYDkLSRALRY Ets protein degradation 27875302 1 1 0 -EDC3 EDC3 RNA processing Q96F86 80153 15q24.1 human Y475-p 1880539206 GEHAGRIyLCDIGIP molecular association, regulation; phosphorylation DCP1A(DISRUPTS); DCP1B(DISRUPTS); DDX6(DISRUPTS) 36476517 1 1 0 primes phosphorylation at S131 and S161 -MPZ myelin P0 Adaptor/scaffold; Membrane protein, integral P25189 4359 1q23.3 human Y220-p 450106 GRQTPVLyAMLDHSR Myelin-PO_C molecular association, regulation 10673375 3 1 1 promotes association with 42, 68, and 85 kDa tyrosine phosphorylated proteins -PFKL PFKL Carbohydrate Metabolism - fructose and mannose; Carbohydrate Metabolism - galactose; Carbohydrate Metabolism - glycolysis and gluconeogenesis; Carbohydrate Metabolism - pentose phosphate pathway; EC 2.7.1.11; Kinase, other P17858 5211 21q22.3 human K689-ac 14367386 AMLWLSEkLREVYRK molecular association, regulation; intracellular localization FBPase(INDUCES) 28424264 1 1 0 regulates formation of multienzyme metabolic complexes -AR AR DNA-binding; Nuclear receptor; Transcription factor P10275 367 Xq12 human S293-p 15605001 PLAECKGsLLDDSAG Androgen_recep activity, induced; molecular association, regulation transcription, altered; cell growth, altered DNA(NOT_REPORTED) 20713353 1 0 0 -Gata1 GATA1 DNA-binding; Transcription factor P17679 14460 X A1.1|X 3.59 cM mouse K246-ac 459077 RPLIRPKkRMIVSKR protein degradation; acetylation; ubiquitination; phosphorylation cell differentiation, induced DNA(INDUCES) 10207073; 16858405 4 0 0 -MET Met EC 2.7.10.1; KINASE; Kinase, protein; Membrane protein, integral; Oncoprotein; Protein kinase, TK; Protein kinase, tyrosine (receptor) P08581 4233 7q31.2 human Y1003-p 448469 VSNESVDyRATFPED activity, induced; protein degradation; protein stabilization; molecular association, regulation; ubiquitination; receptor desensitization, altered; enzymatic activity, induced carcinogenesis, inhibited; cell growth, inhibited; apoptosis, induced; cell motility, induced; cell motility, inhibited; signaling pathway regulation; cell growth, altered Cbl-c(INDUCES); PTP1B(INDUCES); PTPN2(INDUCES); CBL(INDUCES) 11741535; 18819921; 19450681; 24634221; 36268649 16 26 366 -IRX2 IRX2 DNA-binding; Transcription factor Q9PU52 373975 chicken S46-p 452191 SSSGSAFsPYPGSAA transcription, altered 15133517 1 0 0 -PDPK1 PDK1 EC 2.7.11.1; KINASE; Kinase, protein; Nuclear receptor co-regulator; Protein kinase, AGC; Protein kinase, Ser/Thr (non-receptor) O15530 5170 16p13.3 human Y373-p 447694 SEDDEDCyGNYDNLL enzymatic activity, induced apoptosis, altered 11481331; 20044479; 20643654 9 1 0 -Olig2 OLIG2 Oncoprotein; Transcription factor Q9EQW6 50913 16 C3.3|16 52.6 cM mouse S147-p 18357904 GPSVRKLsKIATLLL HLH molecular association, regulation cell differentiation, inhibited; cell differentiation, altered; transcription, inhibited HSPA9B(DISRUPTS); neurogenin 2(DISRUPTS); PARP1(DISRUPTS); OLIG2(INDUCES); HSC70(DISRUPTS) 21382552; 36241911 2 0 0 -MAP4K1 HPK1 EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, STE; Protein kinase, Ser/Thr (non-receptor) Q92918 11184 19q13.2 human S171-p 455474 ATLARRLsFIGTPYW Pkinase protein degradation; enzymatic activity, induced transcription, altered 15743830; 24362026 3 1 13 -PTH PTH Apoptosis; Hormone; Secreted; Secreted, signal peptide P01270 5741 11p15.3 human S32-p 23135902 GKSVKKRsVSEIQLM Parathyroid molecular association, regulation signaling pathway regulation PTHR(INDUCES) 25158085 1 1 11 -CTH CTH Amino Acid Metabolism - cysteine and methionine; Amino Acid Metabolism - glycine, serine and threonine; Cell cycle regulation; EC 4.4.1.1; Energy Metabolism - nitrogen; Lyase; Other Amino Acids Metabolism - selenoamino acid P32929 1491 1p31.1 human K73-ub 3937199 PTRNCLEkAVAALDG Cys_Met_Meta_PP protein degradation 32755037 1 4 1 -DVL2 DVL2 Adaptor/scaffold; Motility/polarity/chemotaxis O14641 1856 17p13.1 human S418-p 56649827 GCEGRGLsVHTDMAS molecular association, regulation; protein conformation transcription, induced; signaling pathway regulation DVL2(INDUCES) 34155117 1 1 0 regulates Wnt Signaling -Bcl2l1 Bcl-xL Apoptosis; Autophagy; Membrane protein, integral; Mitochondrial P53563 24888 3q41 rat S228-p 5014912 AGVVLLGsLFSRK__ apoptosis, altered 18951975 1 0 0 -TRIM28 TIF1B EC 6.3.2.-; KINASE; Kinase, protein; Ligase; Nuclear receptor co-regulator; Protein kinase, atypical; SUMO LIGASE; SUMO ligase; Transcription, coactivator/corepressor; UBIQUITIN LIGASE; Ubiquitin conjugating system; Ubiquitin ligase Q13263 10155 19q13.43 human S823-p 471281 SLPGAGLsSQELSGG phosphorylation 37438603 2 2 3 induces phosphorylation of S824 -TP53 p53 Activator; DNA-binding; Motility/polarity/chemotaxis; Nuclear receptor co-regulator; Transcription factor; Tumor suppressor P04637 7157 17p13.1 human T81-p 447540 APAPAAPtPAAPAPA protein degradation; acetylation; molecular association, regulation; protein stabilization cell cycle regulation; carcinogenesis, induced; cell growth, induced; apoptosis, induced; transcription, induced; transcription, altered MDM2(DISRUPTS); PIN1(INDUCES); PPP1R13L(DISRUPTS) DNA(INDUCES) 11283254; 12397361; 12397362; 17906639; 27147566; 33745968 11 1 1 -Ank3 ANK3 iso4 Adaptor/scaffold; Motility/polarity/chemotaxis XP_006513193 11735 10 B5.3|10 36.1 cM mouse S2619-p 15718933 SQSSTSSsPEKVLTE molecular association, regulation; protein conformation neural plasticity; signaling pathway regulation SPTBN4(INDUCES) 31451636 1 2 0 targeting of SPTBN4 into the palasma membrane is reduced in S1982A mutatnt -REL REL Oncoprotein; Transcription factor Q04864 5966 2p16.1 human S557-p 480318 SNTTVFVsQSDAFEG transcription, altered 17072339 1 0 0 -Runx2 AML3 iso5 DNA-binding; Transcription factor Q08775-5 12393 17 B3|17 21.33 cM mouse S125-p 460037 AELVRTDsPNFLCSV Runt activity, inhibited transcription, inhibited 23918955 4 2 0 -ABI1 Abi-1 Adaptor/scaffold; Motility/polarity/chemotaxis Q8IZP0 10006 10p12.1 human S267-p 18715503 PIAVPTPsPPTIGPE molecular association, regulation cell motility, altered; cytoskeletal reorganization 21419341 1 0 1 regulates WRC (WAVE2 regulatory complex) interaction with Arp2/3 and lamellipodial protrusion -PIK3R2 PIK3R2 Kinase, lipid; Motility/polarity/chemotaxis O00459 5296 19p13.11 human K541-sm 56709100 EIHESRTkLEQQLRA PI3K_P85_iSH2 phosphorylation carcinogenesis, inhibited; signaling pathway regulation 26411363 1 0 0 sumolation inhibits PI3KR2 phosphorylation, regulates PI3K pathway activation -Mitf MITF iso8 DNA-binding; Oncoprotein; Transcription factor Q08874-8 17342 6 D3|6 45.05 cM mouse S409-p 450265 KTSSRRSsMSAEETE DUF3371 molecular association, regulation; intracellular localization transcription, induced; transcription, altered PIAS3(DISRUPTS) 14645519; 15572665 8 5 0 -PIK3C3 PIK3C3 Autophagy; Carbohydrate Metabolism - inositol phosphate; EC 2.7.1.137; Kinase, lipid; Motility/polarity/chemotaxis Q8NEB9 5289 18q12.3 human T159-p 14659500 DGSEPTKtPGRTSST PI3K_C2 molecular association, regulation; enzymatic activity, inhibited endocytosis, altered beclin 1(DISRUPTS) 20513426 2 0 0 inhibits autophagy -Pxn PXN Adaptor/scaffold; Cell adhesion; Cytoskeletal; Motility/polarity/chemotaxis Q66H76 360820 12q16 rat Y118-p 448604 AGEEEHVySFPNKQK Paxillin activity, induced; molecular association, regulation; intracellular localization cell motility, altered DOCK1(INDUCES); CRK(INDUCES) 15308668; 21357465 83 79 2519 activation of Rac1; colocalized in glucose induced filipodia extensions, leading to insulin secretion -BHLHE41 BHLHB3 Q9C0J9 79365 12p12.1 human K210-sm 31094507 CLERAGQkLEPLAYC molecular association, regulation; methylation cell differentiation, inhibited; chromatin organization, altered; transcription, inhibited EHMT2(INDUCES) 23637228 1 0 0 induces histone dimethylation, induces recruitment of EHMT2 to promoters through binding to EHMT2 -Rb1 Rb Nuclear receptor co-regulator; Oncoprotein; Transcription, coactivator/corepressor; Tumor suppressor P13405 19645 14 38.73 cM|14 D3 mouse S601-p 447976 TAADMYLsPLRSPKK molecular association, regulation cell cycle regulation; cell growth, induced; transcription, inhibited E2F1(DISRUPTS) 10207050; 35023164; 9671466 13 10 30 transcriptional downregulation of the E2F-1, E2F-2, dihydrofolate reductase, thymidine kinase, c-myc, proliferating-cell nuclear antigen, p107, and p21/Cip1 genes -SLC6A3 DAT Membrane protein, integral; Membrane protein, multi-pass; Transporter; Transporter, SLC family Q01959 6531 5p15.33 human S12-p 451137 KCSVGLMsSVVAPAK activity, induced 15024426; 16908408 6 0 0 stimulates DAT-mediated efflux of dopamine -HSP90AA1 HSP90A Chaperone; Heat shock protein P07900 3320 14q32.31 human K69-ac 2884401 ESLTDPSkLDSGKEL HATPase_c molecular association, regulation; intracellular localization carcinogenesis, induced; exocytosis, induced CHIP(DISRUPTS); HSP70(DISRUPTS); MMP2(INDUCES) 18559531; 18660379 3 4 4 -NME3 NME3 Apoptosis; EC 2.7.4.6; Kinase, nucleoside diphosphate; Kinase, other; Motility/polarity/chemotaxis; Nucleotide Metabolism - purine; Nucleotide Metabolism - pyrimidine Q13232 4832 16p13.3 human S61-p 3137800 ALKLVQAsEELLREH NDK molecular association, regulation cell differentiation, altered NME1(INDUCES) 11042679 1 0 0 -LMNA lamin A/C Cytoskeletal P02545 4000 1q22 human S22-p 452604 QASSTPLsPTRITRL activity, induced; molecular association, regulation; intracellular localization cell cycle regulation; cytoskeletal reorganization lamin A/C(DISRUPTS) 18815303; 19165338; 24582498; 24741066; 31511386; 34806324; 35839855; 36695453; 7925482 18 96 129 dominant negative mitotic affects, and mitotic assembly and disassembly of lamin -FLNA FLNA Actin-binding; Motility/polarity/chemotaxis; Nuclear receptor co-regulator P21333 2316 Xq28 human S1084-p 452265 LQGGSAGsPARFTID Filamin cell motility, induced; cytoskeletal reorganization 25445790 1 73 4 cell separation following mitosis, AAA mutant has defects in cell motility -ARX ARX Cancer Testis Antigen (CTA); DNA-binding Q96QS3 170302 Xp21.3 human S174-p 1297351802 VSISRSKsYRENGAP activity, induced; molecular association, regulation; intracellular localization transcription, induced PICK1(INDUCES) 30419043 1 1 0 -RUNX1 AML1 iso8 DNA-binding; Oncoprotein; Transcription factor Q01196-8 861 21q22.12 human S303-p 454401 VHPATPIsPGRASGM activity, induced; protein degradation; molecular association, regulation; phosphorylation cell differentiation, induced; cell growth, induced; transcription, induced; cell growth, altered HDAC1(DISRUPTS); HDAC3(DISRUPTS) 16046550; 17015473; 18003885; 21059642; 22531928 13 11 70 -GRAP2 GADS Adaptor/scaffold O75791 9402 22q13.1 human T262-p 451895 ALMHRRHtDPVQLQA intracellular localization; activity, inhibited; phosphorylation 25452106 2 16 142 PLC-gamma phosphorylation. Gads functions as a regulated modulator of cellular signaling to TCR signaling -DENND3 DENND3 GEF; GEF, Rab A2RUS2 22898 8q24.3 human S490-p 23050193 ELAPRNSsLRLTDTA molecular association, regulation 14-3-3 beta(INDUCES) 25925668 2 3 3 enhances its GEF activity toward Rab12 -ASIC1 ASIC1 Channel, cation; Membrane protein, integral; Membrane protein, multi-pass; Transporter; Transporter, ion channel P78348 41 12q13.12 human S40-p 6057800 IFSYERLsLKRALWA ASC activity, inhibited 19091960 1 0 0 -BAIAP2L1 IRTKS Adaptor/scaffold; Cytoskeletal Q9UHR4 55971 7q21.3-q22.1 human Y37-p 21336505 LINLGKNyEKAVNAM IMD cell motility, induced 21840312 1 0 0 -Gata1 GATA1 DNA-binding; Transcription factor P17679 14460 X A1.1|X 3.59 cM mouse K252-ac 459078 KKRMIVSkRAGTQCT protein degradation; acetylation; ubiquitination; phosphorylation DNA(INDUCES) 16858405 2 0 0 Phosphorylation and acetylation cause the degradation of acetylated GATA-1; acetylation of GATA-1 causes ubiquitination; DNA binding is required for MAPK-dependent phosphorylation -SOX2 SOX2 Cell development/differentiation; DNA-binding; Transcription factor P48431 6657 3q26.33 human S249-p 6738004 SVVKSEAsSSPPVVT molecular association, regulation cell cycle regulation; cell differentiation, induced Oct4(INDUCES) RNA(INDUCES) 34497381 1 5 0 -KDM4B JMJD2B DEMETHYLASE; Demethylase; EC 1.14.11.-; Oxidoreductase O94953 23030 19p13.3 human K562-ub 31914120 AQKGPTWkEPVSPME protein degradation 23589305 1 2 0 -Ncoa1 SRC-1 ACETYLTRANSFERASE; Acetyltransferase; DNA-binding; EC 2.3.1.48; Nuclear receptor co-regulator; Oncoprotein; Transcription, coactivator/corepressor P70365 17977 12|12 A1.1 mouse S1272-p 396518804 PVPPPQSsLLQQTPP DUF1518 molecular association, regulation cell differentiation, induced; transcription, induced RORC(INDUCES) 29282318 1 1 0 -MPL MPL Membrane protein, integral; Receptor, cytokine P40238 4352 1p34.2 human K553-ub 11956704 TAALSPPkATVSDTC protein degradation cell growth, inhibited 19880496 1 0 0 -GRK1 GRK1 EC 2.7.11.14; KINASE; Kinase, protein; Protein kinase, AGC; Protein kinase, Ser/Thr (non-receptor) P28327 281457 cow T489-p 2530400 QDVGAFStVKGVAFE molecular association, regulation; enzymatic activity, inhibited PTN(DISRUPTS) 7797516 3 1 0 -STK39 STLK3 EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, STE; Protein kinase, Ser/Thr (non-receptor) Q9UEW8 27347 2q24.3 human S309-p 450930 MMKKYGKsFRKLLSL Pkinase enzymatic activity, induced 14988727 1 0 0 -KIF2B KIF2B Microtubule-binding; Motor Q8N4N8 84643 17q22 human S617-p 25247530 TISGKGSsQWLENIQ intracellular localization cell cycle regulation 22535524 1 1 0 -NR3C2 MCR DNA-binding; Nuclear receptor P08235 4306 4q31.23 human S361-p 25692903 TLRDVVPsPDTQEKG protein degradation; ubiquitination transcription, inhibited 22798426 1 2 0 -MAP1LC3A LC3A Autophagy; Microtubule-binding; Ubiquitin-like modifier; Vesicle Q9H492 84557 20q11.22 human K51-ac 36293441 LPVLDKTkFLVPDHV ATG8 molecular association, regulation; intracellular localization autophagy, inhibited DOR-1(DISRUPTS); ATG7(DISRUPTS) 25601754 1 1 0 -KDM4B JMJD2B DEMETHYLASE; Demethylase; EC 1.14.11.-; Oxidoreductase O94953 23030 19p13.3 human S566-p 452590 PTWKEPVsPMELTGP protein stabilization; ubiquitination 28945223 1 14 0 -TGFBR2 TGFBR2 EC 2.7.11.30; KINASE; Kinase, protein; Membrane protein, integral; Oncoprotein; Protein kinase, Ser/Thr (receptor); Protein kinase, TKL P37173 7048 3p24.1 human S416-p 452049 SVDDLANsGQVGTAR PK_Tyr_Ser-Thr enzymatic activity, inhibited 9155023 1 0 0 -SYT4 SYT4 Calcium-binding; Membrane protein, integral; Vesicle Q9H2B2 6860 18q12.3 human S135-p 4706863 EGEKESVsPESLKSS intracellular localization exocytosis, induced 18046461 2 5 0 -Alyref2 Refbp2 DNA-binding; RNA-binding Q9JJW6 56009 1|1 H3 mouse R171-m1 13906410 GNRGGMTrSRGSGGF FoP_duplication molecular association, regulation RNA(DISRUPTS) 20129943 1 1 0 -Src Src iso1 EC 2.7.10.2; KINASE; Kinase, protein; Oncoprotein; Protein kinase, TK; Protein kinase, tyrosine (non-receptor) P05480-1 20779 2 H1|2 78.35 cM mouse Y221-p 448233 KLDSGGFyITSRTQF SH2 molecular association, regulation GRB2(INDUCES) 11713208 8 3 21 -Kcne2 KCNE2 Membrane protein, integral P63161 171138 11q11 rat S98-p 486280 DWQQKYRsQILHLED ISK_Channel protein degradation 22180649 2 0 0 causes degradation of hERG and reduces its current amplitude and its surface localization -Relb RELB Transcription factor Q04863 19698 7 A3|7 9.93 cM mouse K305-ub 3055601 ELYLLCDkVQKEDIS RHD_dimer transcription, induced 18620544 1 1 0 -SHB SHB Adaptor/scaffold Q15464 6461 9p13.1 human Y246-p 450867 KVTIADDySDPFDAK molecular association, regulation cell motility, induced; signaling pathway regulation RASA1(INDUCES) 32060095 1 28 528 regulates EphB2 signaling -BUB1B BUB1B EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, Other; Protein kinase, Ser/Thr (non-receptor); Tumor suppressor O60566 701 15q15.1 human K250-sm 25174702 IRVGGALkAPSQNRG protein degradation cell cycle regulation 22167194 1 0 0 -Kif3a KIF3A Microtubule-binding; Motor P28741 16568 11 B1.3|11 31.97 cM mouse S689-p 454304 KMGRRKRsAKPETVI activity, induced; molecular association, regulation CDH2(INDUCES) 26335646 3 28 2 enhances N-cadhedrin transport and affects synapse formation -CNN1 calponin 1 Actin-binding; Contractile; Motility/polarity/chemotaxis; Myosin-binding P26932 396522 chicken T170-p 469593 IIGLQMGtNKFASQQ Calponin molecular association, regulation ACTA1(DISRUPTS) 10873572 2 0 0 f-actin (rabbit skeletal muscle) shown by co-sedimentation -STK38 NDR1 EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, AGC; Protein kinase, Ser/Thr (non-receptor) Q15208 11329 6p21.31 human S6-p 22553318 __MAMTGsTPCSSMS enzymatic activity, inhibited; phosphorylation signaling pathway regulation 22142472 1 0 0 induces JNK phosphorylation, regulates cell death through JNK signaling -DLC1 DLC1 GAP; GAP, Rac/Rho; Tumor suppressor Q96QB1 10395 8p22 human T738-p 17434624 KRSVSNStQTSSSSS activity, induced; molecular association, regulation; phosphorylation cell motility, inhibited 25525271 1 1 1 Phosphorylation at T738 and S745 is essential for DLC1-PP2A binding and dephosphorylation -SARS1 SARS Aminoacyl-tRNA synthetase; EC 6.1.1.11; Ligase; RNA processing; Translation; Translation regulation P49591 6301 1p13.3 human S101-p 23141783 ALANLKVsQIKKVRL Seryl_tRNA_N molecular association, regulation carcinogenesis, induced; cell growth, induced; transcription, induced DNA(DISRUPTS) 33351793 1 0 1 -RAD21 RAD21 O60216 5885 8q24.11 human K216-sm 610821404 LEYEDQYkDDNFGEG DNA repair, induced 22751501 1 1 0 -Atp1a1 ATP1A1 EC 3.6.3.9; Hydrolase; Membrane protein, integral; Membrane protein, multi-pass; Transporter; Transporter, ion channel P06685 24211 2q34 rat S23-p 449087 SEHGDKKsKKAKKER protein degradation; receptor internalization, induced; molecular association, regulation; enzymatic activity, inhibited; intracellular localization; protein conformation; enzymatic activity, induced endocytosis, induced 14-3-3 beta(INDUCES); AP2A1(INDUCES) 10933807; 12466249; 12482133; 12671055; 12759348; 15030374; 15722354; 17065225; 19286978; 27605582; 9890946 21 1 0 There may be other phoshorylation and ubiquitylation sites involved. -ANGPTL8 EG624219 Secreted; Secreted, signal peptide Q6UXH0 55908 19p13.2 human T98-p 1869062302 LRASLLEtQMEEDIL phosphorylation 32344005 1 0 0 enhances Akt phosphorylation, regulates signaling pathway AKT-GSK3 ?/-FoxO1 through Akt phosphorylation -KIF14 KIF14 Microtubule-binding; Motor Q15058 9928 1q32.1 human S56-p 31882103 NDDPLLRsAGKVRDI intracellular localization 28630147 1 2 0 spindle localization of Kif14 in anaphase -AIFM1 PDCD8 Apoptosis; EC 1.-.-.-; Mitochondrial; Oxidoreductase O95831 9131 Xq26.1 human S116-p 27455805 KQKKAALsASEGEEV apoptosis, inhibited 29255269 2 9 0 oxeiptosis -XRCC6 Ku70 DNA repair, damage; DNA-binding; EC 3.6.4.-; EC 4.2.99.-; Helicase; Nuclear receptor co-regulator; RNA-binding P12956 2547 22q13.2 human S27-p 449267 QEENLEAsGDYKYSG molecular association, regulation; intracellular localization cell cycle regulation; DNA repair, induced; chromatin organization, altered; DNA repair, altered; apoptosis, inhibited UBE2M(DISRUPTS); UBE2A(INDUCES); RIF1(INDUCES); N4BP1(INDUCES); POLR2F(INDUCES); UBE2G2(INDUCES); TIF1G(INDUCES) DNA(DISRUPTS) 26337656; 34718776 2 14 0 -CBX1 CBX1 Transcription factor P83916 10951 17q21.32 human T51-p 2753801 GFSDEDNtWEPEENL Chromo molecular association, regulation; intracellular localization H3(DISRUPTS) DNA(DISRUPTS) 18438399; 19657222 2 0 0 -Crebbp CBP ACETYLTRANSFERASE; Acetyltransferase; DNA-binding; EC 2.3.1.48; Motility/polarity/chemotaxis; Nuclear receptor co-regulator; Transcription, coactivator/corepressor P45481 12914 16 A1|16 2.4 cM mouse K1034-sm 3726903 LQGSSQVkEETDTTE molecular association, regulation transcription, inhibited DAXX(INDUCES); HDAC2(INDUCES) 16287980 1 1 0 -Mapt Tau ACETYLTRANSFERASE; Acetyltransferase; Cytoskeletal P19332 29477 10q32.1 rat T542-p 449079 KKVAVVRtPPKSPSA neural plasticity; cytoskeletal reorganization 18245083; 33768378 149 48 14 -Cited1 CITED1 Nuclear receptor co-regulator P97769 12705 X D|X 45.25 cM mouse S80-p 27937108 SPTATPSsKPPSFNL CITED intracellular localization cell differentiation, induced 23529225 1 0 0 S63/64/65/67/69/73/79/80/84A mutation in CITED1 inhibits its translocation into the nucleus and osteoblasts differentiation -PXN PXN Adaptor/scaffold; Cell adhesion; Cytoskeletal; Motility/polarity/chemotaxis P49024 395832 chicken S273-p 465466 ELDELMAsLSDFKFM molecular association, regulation; protein conformation cell motility, altered FAK(DISRUPTS) 18092823 12 12 0 -HK2 HK2 Carbohydrate Metabolism - amino sugar and nucleotide sugar; Carbohydrate Metabolism - fructose and mannose; Carbohydrate Metabolism - galactose; Carbohydrate Metabolism - glycolysis and gluconeogenesis; Carbohydrate Metabolism - starch and sucrose; EC 2.7.1.1; Kinase, other; Mitochondrial P52789 3099 2p12 human K492-sm 1881215705 LEVKRRMkVEMERGL carcinogenesis, inhibited; cell growth, inhibited 33753739 1 0 0 SUMO-defective HK2 contributes to prostate cancer cell proliferation and tumorigenesis -PKMYT1 Myt1 EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, Other; Protein kinase, Ser/Thr (non-receptor); Protein kinase, dual-specificity (non-receptor) Q99640 9088 16p13.3 human S441-p 11331000 DSLGPSLsPEAVLAR molecular association, regulation PIN1(INDUCES) 10504341 1 0 0 -CDCP1 CDCP1 Cell surface; Membrane protein, integral Q9H5V8 64866 3p21.31 human Y743-p 455578 VIEDTMVyGHLLQDS molecular association, regulation cell growth, induced SHP-2(INDUCES) 23300860; 25876044 3 0 3 -CCNY CBCP1 Cell cycle regulation Q8ND76 219771 10p11.21 human S326-p 453488 SARKRSAsADNLTLP molecular association, regulation; phosphorylation autophagy, induced 14-3-3 zeta(INDUCES); CDK16(INDUCES) 26205494; 32098961 2 93 52 induces phosphorylation at S336 -Atg13 ATG13 Autophagy; Vesicle Q91YI1 51897 2|2 E1 mouse S354-p 21127300 DTETVSNsSEGRASP carcinogenesis, induced; autophagy, induced; cell growth, induced 35246531 18 5 0 -MCRS1 MCRS1 Nuclear receptor co-regulator; Nucleolus; RNA-binding Q96EZ8 10445 12q13.12 human S36-p 40268168 AGQKRASsQALGTIP cell cycle regulation; cytoskeletal reorganization 27192185 1 2 0 K-fiber formation and dynamics -Sharpin SHARPIN Apoptosis Q91WA6 106025 15 D3|15 35.75 cM mouse K42-ub 54221302 DAEAQPRkLQLIADP Sharpin_PH signaling pathway regulation 26829767 1 1 0 regulation of TCR signaling-maintenance of immuno; ogical signaling K63-linked polyubiquitination -ERRFI1 MIG-6 Inhibitor; Tumor suppressor Q9UJM3 54206 1p36.23 human Y394-p 451607 KKVSSTHyYLLPERP molecular association, regulation EGFR(INDUCES) 26967626; 32574989 4 17 253 -Nherf1 NHERF Adaptor/scaffold; Motility/polarity/chemotaxis P70441 26941 11|11 E2 mouse S77-p 957200 ETHQQVVsRIRAALN PDZ molecular association, regulation SLC34A1(DISRUPTS) 17975671; 20200151 4 0 0 -ACE2 ACE2 EC 3.4.17.23; Membrane protein, integral; Protease Q9BYF1 59272 Xp22.2 human K114-ub 1880091003 VLSEDKSkRLNTILN Peptidase_M2 protein degradation 35894122 1 1 0 -HDAC3 HDAC3 Apoptosis; Cell cycle regulation; DEACETYLASE; Deacetylase; EC 3.5.1.98; Nuclear receptor co-regulator; Transcription, coactivator/corepressor O15379 8841 5q31.3 human Y328-p 1267669101 EELPYSEyFEYFAPD activity, induced; intracellular localization; enzymatic activity, induced carcinogenesis, induced; cell growth, induced 30317579; 31430896 2 0 0 -PRKCB PKCB EC 2.7.11.13; KINASE; Kinase, protein; Motility/polarity/chemotaxis; Protein kinase, AGC; Protein kinase, Ser/Thr (non-receptor) P05771 5579 16p12.2-p12.1 human T642-p 447897 TRQPVELtPTDKLFI Pkinase_C molecular association, regulation; intracellular localization; enzymatic activity, induced CLTA(INDUCES) 17504762; 36717249 14 14 0 -XRCC1 XRCC1 DNA repair, damage P18887 7515 19q13.31 human T367-p 36131476 LICAFANtPKYSQVL BRCT intracellular localization DNA repair, induced 28740101 1 2 0 recruitment of XRCC1 to DNA damage and binding to PARP1/PAR -NUP98 NUP98 iso2 Motility/polarity/chemotaxis; Nucleoporin P52948-2 4928 11p15.4 human S494-p 18330803 HINSLTYsPFGDSPL intracellular localization 21335236 1 1 1 as multiple sites (13PM) mutant -Ikzf1 Ikaros C2H2-type zinc finger protein; DNA-binding; Transcription factor Q03267 22778 11 A1|11 7.02 cM mouse T23-p 4828303 ESPPVSDtPDEGDEP molecular association, regulation; intracellular localization DNA(DISRUPTS) 18223295 1 0 0 -MAP4 MAP4 Cytoskeletal; Motility/polarity/chemotaxis P27816 4134 3p21.31 human K852-ac 62495522 EVKKMTAkSVPADLS cytoskeletal reorganization 28002468 1 1 0 -CALD1 Caldesmon Actin-binding Q05682 800 7q33 human S759-p 448465 KTPDGNKsPAPKPSD Caldesmon molecular association, regulation; intracellular localization; protein conformation cell motility, altered; cytoskeletal reorganization ACTA1(DISRUPTS) 11983427; 16289153; 20128924 7 21 0 -Ctcf CTCF C2H2-type zinc finger protein; Transcription factor; Tumor suppressor Q61164 13018 8|8 D3 mouse K698-sm 6124704 ENIIVEVkKEPDAEP transcription, inhibited 19029252 2 3 0 -TGIF2 TGIF2 DNA-binding Q9GZN2 60436 20q11.23 human T186-p 25174055 LFNTPPPtPPEQDKE molecular association, regulation carcinogenesis, induced; cell motility, induced; transcription, altered HDAC1(INDUCES) DNA(INDUCES) 36647029 1 5 0 -Kcna2 Kv1.2 Channel, potassium; Membrane protein, integral; Membrane protein, multi-pass P63142 25468 2q34 rat Y458-p 19083401 STISKSDyMEIQEGV activity, induced; molecular association, regulation signaling pathway regulation MBP(INDUCES); CNTN2(INDUCES) 21602278 1 0 0 -CGAS cGAS EC 2.7.7.86 Q8N884 115004 6q13 human Y215-p 1271626200 LLNTGSYyEHVKISA Mab-21 molecular association, regulation; enzymatic activity, inhibited; intracellular localization DNA repair, induced; chromatin organization, altered; DNA repair, inhibited DNA(DISRUPTS) 30356214; 31544964 2 0 0 -ZRANB1 ZRANB1 DEUBIQUITINASE; EC 3.4.19.12; Ligase; Protease; Ubiquitin conjugating system; Ubiquitin-specific protease Q9UGI0 54764 10q26.13 human S78-p 1105513501 SARPRVKsSYSMENA enzymatic activity, induced 29748601 1 1 0 phosphorylation induced by AKT induces K63 deubiquitinating activity toward Twist1 -HCFC1 HCFC1 Transcription, coactivator/corepressor P51610 3054 Xq28 human K1808-ub 6423510 PSKAPMKkENQWFDV protein stabilization cell cycle regulation; cell growth, induced 19188440 1 3 0 -CDC73 CDC73 Cell cycle regulation; Tumor suppressor Q6P1J9 79577 1q31.2 human S465-p 1879768900 PWLLPDGsPVDIFAK protein stabilization 35551175 1 0 0 -Hnf4a HNF4 alpha DNA-binding; Nuclear receptor; Transcription factor P49698 15378 2 H3|2 84.32 cM mouse Y286-p 22996302 LQIDDNEyACLKAII Hormone_recep molecular association, regulation SSU72(INDUCES) 34616001 2 1 0 -DLC1 DLC1 GAP; GAP, Rac/Rho; Tumor suppressor Q96QB1 10395 8p22 human S557-p 37038503 LEEFDVFsPKQDLVP activity, induced; intracellular localization; protein conformation carcinogenesis, inhibited; cell growth, inhibited; cell motility, inhibited talin 1(INDUCES); tensin 1 iso1(INDUCES) 25452387 1 1 0 localize to focal adhesions; activates Rho-GAP activity -NCOA1 SRC-1 ACETYLTRANSFERASE; Acetyltransferase; DNA-binding; EC 2.3.1.48; Nuclear receptor co-regulator; Oncoprotein; Transcription, coactivator/corepressor Q15788 8648 2p23.3 human K732-sm 2407403 VQGNSSIkLELDASK intracellular localization transcription, induced PR(INDUCES) 12529333 1 0 0 -OSBP OSBP Lipid-binding P16258 rabbit S384-p 468342 KRTGSNIsGASSDIS phosphorylation 11441133 2 54 1 S381 promotes subsequent phosphorylation of serines 384 and 387 -OTUD6A OTUD6A DEUBIQUITINASE; EC 3.4.19.12; Ubiquitin-specific protease Q7L8S5 139562 Xq13.1 human S74-p 40512708 QDDSSIEsVVEDLAK molecular association, regulation; intracellular localization cell cycle regulation; carcinogenesis, induced TOPBP1(DISRUPTS) 35768646 1 3 0 -SNAI2 Snail2 Apoptosis; C2H2-type zinc finger protein; Motility/polarity/chemotaxis; Transcription factor O43623 6591 8q11.21 human S87-p 25525400 SSSLGRVsPPPPSDT cell motility, induced; transcription, induced 25855378 3 2 0 vimentin transcription -PTEN PTEN iso2 Carbohydrate Metabolism - inositol phosphate; EC 3.1.3.16; EC 3.1.3.48; EC 3.1.3.67; Motility/polarity/chemotaxis; Nuclear receptor co-regulator; PHOSPHATASE; Phosphatase, lipid; Tumor suppressor P60484-2 5728 10q23.31 human K235-ub 1877956800 RFLDSKHkNHYKIYN protein degradation 31685992 1 0 0 -GP1BB GPIbB Cell surface; Membrane protein, integral P13224 2812 22q11.21 human S191-p 456005 ARAAARLsLTDPLVA molecular association, regulation; receptor desensitization, altered cell adhesion, altered 14-3-3 zeta(INDUCES) 12361948; 9454760 5 15 1 -YAP1 YAP1 Oncoprotein; Transcription, coactivator/corepressor P46937 10413 11q22.1 human K497-ub 15400504 LAATKLDkESFLTWL activity, induced; protein degradation; ubiquitination; intracellular localization carcinogenesis, altered; cell motility, inhibited 29891922; 33939216; 36271031 3 2 5 -FMR1 FMR1 Nucleolus; RNA-binding; Translation Q06787 2332 Xq27.3 human S500-p 469583 NSEASNAsETESDHR FXMRP1_C_core molecular association, regulation neural plasticity; RNA stability, induced; cytoskeletal reorganization; translation, inhibited Other(DISRUPTS); RNA(INDUCES) 17376973; 22080836; 31112584; 36181660 21 6 0 inhibits binding to ribosomes; FMRP S500D binds PSD-95 mRNA and miR-125a -MAP4 MAP4 Cytoskeletal; Motility/polarity/chemotaxis P27816 4134 3p21.31 human K938-ac 62495523 DLKNVRSkVGSTENI Tubulin-binding cytoskeletal reorganization 28002468 1 1 0 -Irs1 IRS1 Adaptor/scaffold; Motility/polarity/chemotaxis P35570 25467 9q34 rat S332-p 455323 SDGEGTMsRPASVDG phosphorylation 15574412 2 1 0 decreases tyrosine phosphorylation of IRS-1 and Akt1 phosphorylation upon insulin stimulation -EP300 p300 ACETYLTRANSFERASE; Acetyltransferase; EC 2.3.1.48; Motility/polarity/chemotaxis; Nuclear receptor co-regulator; Transcription, coactivator/corepressor Q09472 2033 22q13.2 human K1020-sm 12063902 EERSTELkTEIKEEE molecular association, regulation transcription, inhibited HDAC6(INDUCES) 12718889 1 0 0 -Irak1bp1 IRAK1BP1 Transcription regulation Q9ESJ7 65099 9|9 E2 mouse T236-p 12524611 QQKIKSAtIHAASKV SIMPL intracellular localization transcription, altered 17079333 1 0 0 nuclear localization -Bmpr1a BMPR1A EC 2.7.11.30; KINASE; Kinase, protein; Membrane protein, integral; Protein kinase, Ser/Thr (receptor); Protein kinase, TKL P36895 12166 14 B|14 20.81 cM mouse Y467-p 25655001 MVPSDPSyEDMREVV PK_Tyr_Ser-Thr molecular association, regulation cell growth, induced; signaling pathway regulation BMPR2(INDUCES); TAB1(DISRUPTS) 22729085 1 1 0 regulation of BMP downstream pathways-Erk1/2 and Smad1 activation, regulates life span of osteoblasts (expansion) -FOXP2 FOXP2 C2H2-type zinc finger protein; DNA-binding O15409 93986 7q31.1 human S557-p 1147026601 NAVRHNLsLHKCFVR Forkhead molecular association, regulation; protein conformation transcription, altered DNA(DISRUPTS) 29845391 1 0 0 -PXN PXN Adaptor/scaffold; Cell adhesion; Cytoskeletal; Motility/polarity/chemotaxis P49024 395832 chicken S190-p 471383 VIPESSSsAGGKAAP Paxillin protein stabilization cell motility, altered 17121676 2 1 0 promotes cell spreading by increasing the dynamics of membrane protrusions -Gria3 GluR3 Channel, ligand-gated; Membrane protein, integral; Membrane protein, multi-pass Q9Z2W9 53623 X A4|X 23.19 cM mouse S885-p 456291 YNVYGTEsVKI____ neural plasticity 32071234 4 0 0 -VAV1 VAV1 GEF; GEF, Rac/Rho; Motility/polarity/chemotaxis; Oncoprotein P15498 7409 19p13.3 human Y826-p 450351 GWWRGEIyGRVGWFP SH3_1 activity, induced; molecular association, regulation carcinogenesis, altered; cell growth, altered CSK(INDUCES); Abl(INDUCES); SHC1(INDUCES); SH2D1A(INDUCES) 20457609 1 6 91 -HTT Huntingtin Cytoskeletal P42858 3064 4p16.3 human S430-p 2020881 LIAGGGSsCSPVLSR protein stabilization 22623107 1 6 4 reduced cell viability and enhanced protein accumulation in S430A mutant -Camkk1 CAMKK1 EC 2.7.11.17; KINASE; Kinase, protein; Protein kinase, Other; Protein kinase, Ser/Thr (non-receptor) P97756 60341 10q24 rat S74-p 452115 SLSARKFsLQERPAG molecular association, regulation; enzymatic activity, inhibited; phosphorylation 14-3-3 gamma(INDUCES); 14-3-3 eta(INDUCES) 15469938 4 19 8 binding of 14-3-3 leads to enzymatic inhibition and protection of CAMKK1 phospho-T108 -Clk2 CLK2 EC 2.7.12.1; KINASE; Kinase, protein; Protein kinase, CMGC; Protein kinase, dual-specificity (non-receptor) O35491 12748 3|3 F1 mouse S98-p 471940 YDTDFRQsYEYHREN protein degradation 20074525 1 6 5 -PRDX6 PRDX6 Amino Acid Metabolism - phenylalanine; EC 1.11.1.15; EC 1.11.1.9; Energy Metabolism - methane; Oxidoreductase; Phospholipase P30041 9588 1q25.1 human T177-p 3823356 TAEKRVAtPVDWKDG 1-cysPrx_C enzymatic activity, induced 19140803; 28055018 4 5 12 essential for optimum PLA2 activity; in vitro -TUBB1 TUBB1 Cytoskeletal; Motility/polarity/chemotaxis Q9H4B7 81027 20q13.32 human K252-ac 7807300 QLNADLRkLAVNMVP intracellular localization cytoskeletal reorganization 21177827 1 1 12 -ARAF ARAF EC 2.7.11.1; KINASE; Kinase, protein; Oncoprotein; Protein kinase, Ser/Thr (non-receptor); Protein kinase, TKL P10398 369 Xp11.3 human S262-p 3306309 RGSPSPAsVSSGRKS enzymatic activity, induced 18662992 1 2 0 -TP53 p53 Activator; DNA-binding; Motility/polarity/chemotaxis; Nuclear receptor co-regulator; Transcription factor; Tumor suppressor P04637 7157 17p13.1 human T377-p 3309800 KSKKGQStSRHKKLM molecular association, regulation; intracellular localization apoptosis, induced; transcription, induced; translation, induced S100B(DISRUPTS); S100A2(DISRUPTS) 19819244; 26384650; 27914807 5 0 0 nuclear accumulation, p21 transcription, cleaved PARP and cytotoxicity ; T304/377D p53 induces TNF-alpha mRNA, secretion of pro-in?ammatory cytokine TNF-alpha, and apoptosis -AKT1 Akt1 EC 2.7.11.1; KINASE; Kinase, protein; Oncoprotein; Protein kinase, AGC; Protein kinase, Ser/Thr (non-receptor) P31749 207 14q32.33 human K276-sm 31089528 NVVYRDLkLENLMLD Pkinase sumoylation; protein stabilization; intracellular localization; phosphorylation; enzymatic activity, induced neural plasticity; cell cycle regulation; carcinogenesis, induced; RNA splicing, induced; cell motility, induced; cell growth, induced; signaling pathway regulation 23884910; 24013425; 25867063; 34288124 4 1 0 Sumoylation at K64 and K276 increases T308 phosphorylation upregulates kinase activity.activates ERK-Elk-1Arc/BDNF and mTOR-P70S6k-4E-BP1 signaling, hippocampal LTP regulation; increases global sumoylation -Vim Vimentin Cytoskeletal; Motility/polarity/chemotaxis P31000 81818 17q12.3 rat S55-p 476052 TSRSLYSsSPGGAYV Filament_head cytoskeletal reorganization 12686602 4 23 30 Vimentin is phosphorylated during S55 during mitosis and is not affected by nestin. -KIF2C KIF2C Cancer Testis Antigen (CTA); Microtubule-binding; Motility/polarity/chemotaxis; Motor Q99661 11004 1p34.1 human S192-p 2132102 VNSVRRKsCLVKEVE intracellular localization; activity, inhibited cytoskeletal reorganization 14960279; 23055517 5 2 25 Inhibits its microtubule depolymerization activity -Etv4 ETV4 DNA-binding P28322 18612 11 D|11 65.48 cM mouse K38-ac 26373309 ALMVPQGkLMDPGSL ETS_PEA3_N sumoylation transcription, induced 21543453 1 1 0 acetylated sites inhibits sumoylation reciprocally -MAPT Tau iso8 ACETYLTRANSFERASE; Acetyltransferase; Cytoskeletal P10636-8 4137 17q21.31 human S400-p 449130 VYKSPVVsGDTSPRH molecular association, regulation Tau iso8(INDUCES) 15190058 13 44 70 polymerized into filaments when 4?6 mol of phosphate per mol of tau were incorporated -PGM1 PGM1 Carbohydrate Metabolism - amino sugar and nucleotide sugar; Carbohydrate Metabolism - galactose; Carbohydrate Metabolism - glycolysis and gluconeogenesis; Carbohydrate Metabolism - pentose phosphate pathway; Carbohydrate Metabolism - starch and sucrose; EC 5.4.2.2; Isomerase P36871 5236 1p31.3 human S117-p 2525691 GGIILTAsHNPGGPN PGM_PMM_I protein conformation; enzymatic activity, induced 25288802 0 69 6 initiation of catalysis by PGM1 is dependent on phosphoryl transfer from phosphoserine 117 -P2ry2 P2Y2 GPCR, family 1; Membrane protein, integral; Membrane protein, multi-pass; Receptor, GPCR; Receptor, misc. P41232 29597 1q32 rat T343-p 2909201 GLHRPNRtDTVRKDL receptor internalization, induced 31289122 2 0 0 Regulates ATP induced calcium response -MISP MISP Unknown function Q8IVT2 126353 19p13.3 human S575-p 459691 ALFPEVFsPTPDENS AKAP2_C molecular association, regulation ACTA1(DISRUPTS) 34023777 1 19 0 -Bcl2 Bcl-2 Apoptosis; Autophagy; Membrane protein, integral; Oncoprotein P10417 12043 1 E2.1|1 49.76 cM mouse T69-p 448398 HRDMAARtSPLRPLV protein stabilization; phosphorylation cell cycle regulation; autophagy, induced; apoptosis, inhibited 14660795; 32051584 11 0 0 induces AMPK, TBC1D1 phosphorylation -Ikzf1 Ikaros C2H2-type zinc finger protein; DNA-binding; Transcription factor Q03267 22778 11 A1|11 7.02 cM mouse S384-p 451349 VSSEREAsPSNSCQD activity, inhibited cell cycle regulation DNA(DISRUPTS) 15024069 1 3 2 -NUTM1 NUTM1 Unknown function Q86Y26 256646 15q14 human S1026-p 13165101 NFAYLLAsKLSLSPR NUT intracellular localization 17934517 1 0 0 nuclear-cytoplasmic shuttling -IFIH1 MDA5 Apoptosis; EC 3.6.4.13; Helicase Q9BYX4 64135 2q24.2 human S88-p 27807804 EALRRTGsPLAARYM CARD_2 molecular association, regulation; enzymatic activity, inhibited; activity, inhibited transcription, induced; transcription, inhibited; signaling pathway regulation IRF3(DISRUPTS); MAVS(DISRUPTS) RNA(INDUCES) 23499489; 28250012; 36113429 4 1 0 -Hdac4 HDAC4 DEACETYLASE; Deacetylase; EC 3.5.1.98; Hydrolase; Nuclear receptor co-regulator; SUMO LIGASE Q6NZM9 208727 1|1 D mouse S245-p 448488 FPLRKTAsEPNLKLR intracellular localization; enzymatic activity, inhibited transcription, altered 36477534; 36477539 13 24 25 -Zc3hav1 ZAP RNA-binding; Transferase Q8K3Y6 252832 4q22 rat S274-p 3203919 PLGSGPPsPDVTSCK activity, induced 22514281 1 40 12 -DOK1 DOK1 Adaptor/scaffold; Motility/polarity/chemotaxis Q99704 1796 2p13.1 human S439-p 454882 EPGTATGsGIKSHNS cell motility, induced; cell growth, inhibited 15574499 1 1 0 -GRB2 GRB2 Adaptor/scaffold; Cell development/differentiation; Motility/polarity/chemotaxis P62993 2885 17q25.1 human Y37-p 7388001 EECDQNWyKAELNGK SH3_1 cell growth, altered 19273609 1 0 0 regulates cell proliferation -Plk4 PLK4 EC 2.7.11.21; KINASE; Kinase, protein; Nucleolus; Protein kinase, Other; Protein kinase, Ser/Thr (non-receptor) Q64702 20873 3|3 B mouse S291-p 12654010 DSGHATLsTTITASS protein degradation; ubiquitination 20100909 2 1 0 -MAPK8 JNK1 EC 2.7.11.24; KINASE; Kinase, protein; Protein kinase, CMGC; Protein kinase, Ser/Thr (non-receptor) P45983 5599 10q11.22 human T183-p 447643 AGTSFMMtPYVVTRY Pkinase enzymatic activity, induced cell cycle regulation; carcinogenesis, induced; apoptosis, altered; carcinogenesis, inhibited; apoptosis, induced; cell motility, inhibited; transcription, induced; transcription, altered; signaling pathway regulation; cell differentiation, induced; cell growth, induced; cell adhesion, altered 10867021; 12368275; 15944157; 17210579; 28068431; 31575661; 33573023; 34034759; 34048499; 35154579; 35790913; 35843311; 36289618; 37298039; 8137421; 9312068 275 33 392 -NCOR1 N-CoR1 Nuclear receptor co-regulator; Transcription, coactivator/corepressor O75376 9611 17p12-p11.2 human S1450-p 1210494 TVRSRHTsVVSSGPS protein conformation transcription, induced 23940660 1 12 48 N-CoR misfolding, Flt3 derepression -LARS1 LARS Amino Acid Metabolism - valine, leucine and isoleucine biosynthesis; Aminoacyl-tRNA synthetase; EC 6.1.1.4; Ligase; Translation; Translation regulation Q9P2J5 51520 5q32 human T293-p 1345849602 NIFLVAAtLRPETMF tRNA-synt_1 molecular association, regulation; activity, inhibited autophagy, inhibited LC3B(INDUCES) 30411383 1 0 0 decreases LARS binding to leucine in the presence of isoleucine (activity inhibited) and as a result increases accumulation of misfolded proteins and ER stress; increases GRP78/BiP levels -SAMSN1 SAMSN1 Adaptor/scaffold Q9NSI8 64092 21q11.2 human S23-p 467324 QKPKRSSsFGNFDRF SLY molecular association, regulation; intracellular localization 14-3-3 beta(INDUCES); 14-3-3 gamma(INDUCES) 20478393 1 19 1 -IQGAP1 IQGAP1 GAP; GAP, Ras; Motility/polarity/chemotaxis P46940 8826 15q26.1 human S480-p 1869135500 NTVWKQLsSSVTGLT activity, induced carcinogenesis, induced; cell motility, induced; signaling pathway regulation 31431460 1 1 0 activates CDC4 and RAC1 -METTL3 METTL3 EC 2.1.1.62; METHYLTRANSFERASE; Methyltransferase; RNA processing Q86U44 56339 14q11.2 human S525-p 1871246003 YGMIERLsPGTRKIE MT-A70 protein stabilization; molecular association, regulation; ubiquitination; methylation carcinogenesis, induced; cell differentiation, induced; translation, induced USP5(DISRUPTS); PIN1(INDUCES) 33217317; 36755057 2 1 0 inhibits stabilization -Ctnnb1 CTNNB1 Actin-binding; Cell adhesion; Motility/polarity/chemotaxis; Nuclear receptor co-regulator; Oncoprotein; Transcription factor Q02248 12387 9 F4|9 72.19 cM mouse K49-ac 458938 TAPSLSGkGNPEEED transcription, inhibited 11973335 17 0 0 -Pitpnb PITPNB Lipid-binding P53811 56305 5|5 F mouse S165-p 451298 EDPALFHsVKTKRGP IP_trans activity, induced 11953429 1 0 0 -Mos MOS EC 2.7.11.1; KINASE; Kinase, protein; Oncoprotein; Protein kinase, Other; Protein kinase, Ser/Thr (non-receptor) P00536 17451 4 A1|4 2.16 cM mouse S232-p 450040 DLRCRQAsPHHIGGT Pkinase activity, inhibited 8622681 1 0 0 -PRKCI PKCI Cell adhesion; Cell development/differentiation; EC 2.7.11.13; KINASE; Kinase, protein; Motility/polarity/chemotaxis; Oncoprotein; Protein kinase, AGC; Protein kinase, Ser/Thr (non-receptor); Tumor suppressor P41743 5584 3q26.2 human Y430-p 482865 EILRGEDyGFSVDWW Pkinase protein conformation 17335005 1 0 0 -H3c1 H3 DNA-binding P68433 360198 13|13 A3.1 mouse K36-m1 465523 APATGGVkKPHRYRP Histone endocytosis, altered; cell adhesion, altered 33195484 17 19 47 axon guidance -GPSM3 GPSM3 G protein regulator, misc. Q9Y4H4 63940 6p21.32 human S39-p 4717970 PWRSAPPsPPPPGTR protein stabilization; molecular association, regulation; intracellular localization 14-3-3 beta(INDUCES) 22843681 1 27 9 -Ski SKI Cell cycle regulation; Oncoprotein; Transcription, coactivator/corepressor; Ubiquitin conjugating system XP_017449382 313757 rat S382-p 11145003 LSAFRPWsPAVSASE protein stabilization; molecular association, regulation; ubiquitination; intracellular localization autophagy, inhibited; transcription, inhibited RNF111(DISRUPTS) 34390788 3 10 7 inhibits ubiquitination -Esr1 ER-alpha DNA-binding; Nuclear receptor; Transcription factor P19785 13982 10 A1|10 2.03 cM mouse S171-p 448102 NGRERLSsSNEKGNM Oest_recep activity, induced cell differentiation, induced; transcription, induced 16585156; 28686577 48 6 0 -Axin1 axin 1 Adaptor/scaffold; Tumor suppressor O35625 12005 17 A3.3|17 13.07 cM mouse S157-p 27266401 LDSNGIVsRQTKPAT RGS molecular association, regulation cell cycle regulation TUBG1(DISRUPTS) 23155463 1 1 0 S157A mutant leads to an increased number of multi-centrosome containing mitotic cells; regulates centrosome duplication -SGTA SGTA Chaperone O43765 6449 19p13.3 human S305-p 479908 QIRSRTPsASNDDQQ molecular association, regulation PDGFRA(INDUCES) 20736484 1 60 567 -KLC1 KLC1 Microtubule-binding; Motor Q07866 3831 14q32.33 human S460-p 477826 YKACKVDsPTVTTTL protein processing 31806024 3 41 3 inhibits the axonal transport; promotes amyloidogenic processing of APP -ETV1 ETV1 DNA-binding; Oncoprotein; Transcription factor P50549 2115 7p21.2 human S94-p 3059606 KIKKEPHsPCSEISS ETS_PEA3_N activity, induced transcription, induced 12213813 2 0 0 -HIF1A HIF1A Autophagy; DNA-binding; Transcription factor Q16665 3091 14q23.2 human K21-ac 25126716 SSERRKEkSRDAARS protein degradation transcription, inhibited 21917920; 28319066 2 0 0 -SDCBP syntenin Adaptor/scaffold; Cell adhesion; Cytokine; Membrane protein, integral; Motility/polarity/chemotaxis; Vesicle O00560 6386 8q12.1 human Y4-p 23940700 ____MSLyPSLEDLK molecular association, regulation cell motility, induced; cytoskeletal reorganization MPRIP(INDUCES) 22349701 1 1 0 T-cell chemotaxis induced, Rac1 activation and translocation to plasma membrane induced -PRMT1 PRMT1 EC 2.1.1.125; METHYLTRANSFERASE; Methyltransferase; Methyltransferase, protein arginine; Nuclear receptor co-regulator Q99873 3276 19q13.33 human S307-p 10793949 GFSTSPEsPYTHWKQ methylation; enzymatic activity, induced apoptosis, induced; transcription, induced 31235809 2 5 3 -CHRM2 mAChR M2 GPCR, family 1; Membrane protein, integral; Membrane protein, multi-pass; Receptor, GPCR P08172 1129 7q33 human S311-p 459109 DENTVSTsLGHSKDE 7tm_1 receptor desensitization, altered; receptor internalization, altered 9162044 3 0 0 Mutation of 4 S/T to A eliminates receptor desensitization in response to carbachol treatment (as measured by isoproterenol-stimulated cAMP production after pretreatment with carbachol).; Mutation of S286 T287 S288 S290 to A caused a faster rate and a greater extent of receptor internalization after agonist stimulation (transients only, not observed in stables). Mutation of all 8 sites prevented internalization (in both transients and stables). -NPHS1 NPHS1 Cell adhesion; Immunoglobulin superfamily; Membrane protein, integral O60500 4868 19q13.12 human Y1193-p 469565 SGAWGPLyDEVQMGP molecular association, regulation; intracellular localization endocytosis, induced; exocytosis, induced; cell adhesion, induced; cytoskeletal reorganization; transcription, induced; endocytosis, inhibited NPHS2(INDUCES); ARRB2(DISRUPTS) 16968782; 22718751; 36822326 16 1 0 -Egfr EGFR EC 2.7.10.1; KINASE; Kinase, protein; Membrane protein, integral; Oncoprotein; Protein kinase, TK; Protein kinase, tyrosine (receptor) Q01279 13649 11 A2|11 9.41 cM mouse Y871-p 448061 LGAEEKEyHAEGGKV PK_Tyr_Ser-Thr carcinogenesis, induced; cell motility, induced; transcription, induced; signaling pathway regulation 18255094; 23652203; 36385375 97 20 171 -Gna11 G-alpha 11 G protein; G protein, heterotrimeric; G protein, heterotrimeric alpha G(q) P21278 14672 10 C1|10 39.72 cM mouse Y356-p 448561 LQLNLKEyNLV____ activity, induced 11994281; 9188537 2 0 2 -ZBTB33 Kaiso C2H2-type zinc finger protein; DNA-binding; Transcription factor Q86T24 10009 Xq24 human T606-p 34353150 YLSDRSStIPAMKDD molecular association, regulation carcinogenesis, inhibited; cell growth, inhibited; transcription, induced; cell motility, inhibited 14-3-3 sigma(INDUCES); 14-3-3 zeta(INDUCES); 14-3-3 epsilon(INDUCES); 14-3-3 gamma(INDUCES) 35851744 1 0 1 -CIC capicua DNA-binding; Transcription factor Q96RK0 23152 19q13.2 human S1409-p 453485 SAPEDPTsPKRKMRR molecular association, regulation; intracellular localization KPNA3(DISRUPTS) 21087211 1 31 25 -SCN5A SCN5A Channel, sodium; Membrane protein, integral; Membrane protein, multi-pass Q14524 6331 3p22.2 human S516-p 4719558 LSLTRGLsRTSMKPR Na_trans_cytopl methylation; activity, inhibited 22514276; 25501501 5 7 0 inhibits SCN5A methylation at R513 -USP16 USP16 DEUBIQUITINASE; EC 3.4.19.12; Protease; Ubiquitin conjugating system; Ubiquitin-specific protease Q9Y5T5 10600 21q21.3 human S330-p 29614602 ILKAFGNsTEKLDEE UCH enzymatic activity, induced 26323689 1 2 0 -FOXA1 FOXA1 DNA-binding; Transcription factor P55317 3169 14q21.1 human K267-ac 11263051 LRRQKRFkCEKQPGA molecular association, regulation chromatin organization, altered DNA(DISRUPTS) 19897491 1 0 0 -BMAL1 BMAL1 DNA-binding; Transcription factor O00327 406 11p15.3 human S78-p 3638466 KNAREAHsQIEKRRR HLH molecular association, regulation transcription, inhibited DNA(DISRUPTS) 23229515 2 0 1 regulates the circadian clock -SUGT1 SUGT1 Cell cycle regulation; Ubiquitin conjugating system Q9Y2Z0 10910 13q14.3 human S321-p 23149643 QQIYSDGsDEVKRAM SGS protein stabilization; molecular association, regulation cell cycle regulation RNF41(INDUCES) 28696259 1 10 1 -BTLA BTLA Membrane protein, integral Q7Z6A9 151888 3q13.2 human Y226-p 1869334004 LLSETGIyDNDPDLC phosphorylation signaling pathway regulation 32437509 1 0 0 inhibits IL2 production, phosphorylation of CD3Z and CD28, and hence T cell signaling -Mapk8ip1 JIP1 Adaptor/scaffold Q9WVI9 19099 2|2 E1 mouse Y427-p 234613500 ESAIGEEyEEAPQPR molecular association, regulation Src iso1(INDUCES) 28930674 1 0 0 -Dapk3 DAPK3 EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, CAMK; Protein kinase, Ser/Thr (non-receptor); Tumor suppressor O54784 13144 10 C1|10 39.72 cM mouse T265-p 454892 KDPKRRMtIAQSLEH Pkinase enzymatic activity, induced apoptosis, induced 16325270 4 2 0 A T265A mutant is unable to activate STAT3 in response to IL-6 stimulation -NPM/ALK NPM-ALK KINASE; Kinase, protein; Protein kinase, TK; Protein kinase, tyrosine (receptor) AAA58698 human Y567-p 27275100 TSLWNPTyGSWFTEK molecular association, regulation transcription, induced SNTB1(INDUCES); SHC1(INDUCES) 17086210; 17110082; 8633037 4 2 1 -KLC2 KLC2 Microtubule-binding; Motor Q9H0B6 64837 11q13.2 human S545-p 3892542 GSLRRSGsFGKLRDA molecular association, regulation 14-3-3 beta(INDUCES) 21725060 1 10 10 mutation of this site prevents 14-3-3 binding (pan-14-3-3 antibody) -CENPQ CENPQ Q7L2Z9 55166 6p12.3 human S248-p 40245501 DLDILHNsSQMKSMS CENP-Q molecular association, regulation; intracellular localization DNA(DISRUPTS) 25670858 1 1 0 CENPQ phosphorylation promotes the delocalization of the PBIP1-CENPQ complex from kinetochores -Chek2 Chk2 EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, CAMK; Protein kinase, Ser/Thr (non-receptor); Tumor suppressor Q9Z265 50883 5|5 F mouse T391-p 447552 LMRTLCGtPTYLAPE Pkinase DNA repair, induced; apoptosis, induced 35663228 18 5 0 -GJA1 GJA1 Channel, misc.; Membrane protein, integral; Membrane protein, multi-pass; Motility/polarity/chemotaxis P17302 2697 6q22.31 human Y247-p 447814 VKGKSDPyHATSGAL intracellular localization; protein conformation 23828237; 30448479 14 9 248 contributes to gap junction disassembly -Cdc25b CDC25B EC 3.1.3.48; Motility/polarity/chemotaxis; Nuclear receptor co-regulator; PHOSPHATASE; Protein phosphatase, dual-specificity P30306 12531 2 F1|2 63.29 cM mouse S351-p 452008 VQSKRRKsVTPLEEQ M-inducer_phosp cell cycle regulation; cytoskeletal reorganization 17554083; 25349079 8 13 9 promotes meiotic resumption -Cdkn1a p21Cip1 Cell cycle regulation; Inhibitor P39689 12575 17 A3.3|17 15.12 cM mouse S78-p 14577356 GLPKVYLsPGSRSRD activity, inhibited apoptosis, altered 21325496 2 9 0 S78 phosphorylation limits p21 inhibition of Cdk2. S78 regulates apoptosis in response to cisplatin. -MRE11 MRE11A Cell cycle regulation; DNA repair, damage; DNA-binding; Deoxyribonuclease P49959 4361 11q21 human S676-p 460788 TSSSKIMsQSQVSKG molecular association, regulation DNA repair, induced; chromatin organization, altered DNA(DISRUPTS) 19709933; 26240375 2 9 12 -PPARG PPAR-gamma iso2 DNA-binding; Nuclear receptor; Transcription factor P37231-2 5468 3p25.2 human S84-p 448062 AIKVEPAsPPYYSEK cell growth, induced; transcription, induced 27769068 33 7 0 promoter of PFKFB4 -Thrb TR-beta1 iso2 DNA-binding; Nuclear receptor P37242-2 21834 mouse S101-p 1877436600 KPFPQVQsPPHSQKK molecular association, regulation transcription, inhibited RXRA(INDUCES); TR-beta1 iso2(DISRUPTS) 34544870 1 1 0 -NFATC1 NFAT2 DNA-binding; Transcription factor O95644 4772 18q23 human K612-ac 9908948 SYPVVGGkKMVLSGH RHD_dimer protein stabilization; phosphorylation 32696520 1 0 1 hypoacetylation, induced higher phosphorylation, induces hair loss (regulated by Sirt7) -Rara RARA DNA-binding; Nuclear receptor; Oncoprotein; Transcription factor P11416 19401 11 D|11 62.76 cM mouse K109-me 4089801 VSACEGCkGFFRRSI zf-C4 activity, induced; molecular association, regulation transcription, induced RXRA(INDUCES); PCAF(INDUCES); RIP140(INDUCES) 18781795 1 1 0 -Rab3il1 RAB3IL1 GEF; GEF, Rab Q99NH3 171452 1q43 rat S180-p 467059 ELHPQLLsPTKAGPR activity, inhibited cell motility, induced; cytoskeletal reorganization 28123016 1 21 23 suppresses RAB3IL1 GEF activity; regulates axonal outgrowth -Mok MOK EC 2.7.11.22; KINASE; Kinase, protein; Protein kinase, CMGC; Protein kinase, Ser/Thr (non-receptor) Q9WVS4 26448 12|12 F1 mouse Y161-p 450006 SKQPYTEyISTRWYR Pkinase activity, induced 10421840 1 1 0 While the authors did not prove that these sites were phosphorylated, mutation of both T159 and Y161, located in the activation loop, abolished the enzymatic activity of the kinase. -HADHA HADHA ACETYLTRANSFERASE; Acetyltransferase; Amino Acid Metabolism - lysine degradation; Amino Acid Metabolism - tryptophan; Amino Acid Metabolism - valine, leucine and isoleucine degradation; Carbohydrate Metabolism - butanoate; Carbohydrate Metabolism - propanoate; EC 1.1.1.211; EC 4.2.1.17; Lipid Metabolism - fatty acid; Lipid Metabolism - fatty acid elongation in mitochondria; Lipid Metabolism - unsaturated fatty acid biosynthesis; Lyase; Mitochondrial; Other Amino Acids Metabolism - beta-alanine; Oxidoreductase; Secondary Metabolites Metabolism - limonene and pinene degradation P40939 3030 2p23.3 human K383-ub 56842401 IAQVSVDkGLKTILK 3HCDH_N protein degradation; ubiquitination 27457618 1 0 0 -TRIM65 TRIM65 Ubiquitin conjugating system Q6PJ69 201292 17q25.1 human S166-p 1871608301 LLELRKQsSQIQNSA carcinogenesis, inhibited; signaling pathway regulation 31332286 1 1 0 dephosphorylated form (6A mutant) contributes to TRIM65 function in tumor progression -BCL9 Bcl-9 Oncoprotein; Transcription factor O00512 607 1q21.2 human K212-ub 1878196102 IQNISNNkTERSTAP molecular association, regulation cell growth, inhibited CTNNB1(DISRUPTS); PYGO1(DISRUPTS) 31073027 1 1 0 ubiquitination inhibits Beta-catenin/BCL9/PYGO1 complex and proliferation and breast cancer cell proliferation -PDHA1 PDHA1 Amino Acid Metabolism - valine, leucine and isoleucine biosynthesis; Carbohydrate Metabolism - butanoate; Carbohydrate Metabolism - citrate (TCA) cycle; Carbohydrate Metabolism - glycolysis and gluconeogenesis; Carbohydrate Metabolism - pyruvate; EC 1.2.4.1; Mitochondrial; Oxidoreductase P08559 5160 Xp22.12 human S314-p 1868287349 IQEVRSKsDPIMLLK E1_dh molecular association, regulation; phosphorylation; enzymatic activity, induced carcinogenesis, induced; apoptosis, inhibited PDHK1(DISRUPTS) 33022274 1 2 0 inhibits phosphorylation at S293 and induces phosphorylation at S295 -GRIA1 GluR1 Channel, calcium; Channel, ligand-gated; Membrane protein, integral; Membrane protein, multi-pass P42261 2890 5q33.2 human S863-p 448566 TSTLPRNsGAGASSG molecular association, regulation; ubiquitination NEDD4(DISRUPTS) 28377502 102 0 0 GluA1 ubiquitin-deficient mutant enhances GluA1 phosphorylation on S863, blocks GluA1 ubiquitination by reducing its interaction with Nedd4 -PRKD3 PRKD3 EC 2.7.11.13; KINASE; Kinase, protein; Protein kinase, CAMK; Protein kinase, Ser/Thr (non-receptor) O94806 23683 2p22.2 human S731-p 456755 ARIIGEKsFRRSVVG Pkinase intracellular localization; enzymatic activity, induced cell motility, induced 16198087; 18692497; 24840177 3 13 19 Loss of Barbed End Formation for activities above basal level -TOP2A TOP2A EC 5.99.1.3; Isomerase P11388 7153 17q21.2 human K662-sm 55439454 KKQIDDRkEWLTNFM TOPRIM_C activity, induced; intracellular localization 30871006 1 2 0 influences mitotic localization of TOP2A -Septin3 SEPT3 Cell cycle regulation; Cytoskeletal; Hydrolase Q9WU34 56003 7q34 rat S91-p 453431 SQVSRKAsSWNREEK Septin intracellular localization 15107017 1 0 1 -DROSHA DROSHA EC 3.1.26.3; Nucleolus; RNA processing; RNA-binding; Ribonuclease Q9NRR4 29102 5p13.3 human S221-p 23100760 KAPSERRsPERLKHY molecular association, regulation DGCR8(DISRUPTS) 25699712 1 4 1 -Bnip3 BNIP3 Membrane protein, integral; Mitochondrial Q9ET45 84480 1q41 rat S60-p 17548869 SKSSHCDsPPRSQTP BNIP3 protein stabilization; molecular association, regulation; ubiquitination autophagy, induced LC3B(INDUCES); ubiquitin(DISRUPTS) 36396625 2 14 0 inhibits ubiquitination, induces mitophagy -Ifitm3 IFITM3 Cell surface; Membrane protein, integral Q9CQW9 66141 7|7 F5 mouse Y20-p 463584 SGGQPPNyERIKEEY ubiquitination; intracellular localization carcinogenesis, induced; cell growth, induced; signaling pathway regulation; endocytosis, inhibited 24627473; 33149299 5 10 18 induces PI3K-signaling; ubiquitination, decreased -Tal1 TAL1 DNA-binding; Oncoprotein; Transcription factor P22091 21349 4 D1|4 52.73 cM mouse K222-ac 458992 PTHPPDKkLSKNEIL HLH molecular association, regulation cell differentiation, induced; transcription, induced SIN3A(DISRUPTS) DNA(INDUCES) 11118214 1 1 0 -DNM1L DRP1 Apoptosis; EC 3.6.5.5; Endoplasmic reticulum; Hydrolase; Microtubule-binding; Mitochondrial; Motor O00429 10059 12p11.21 human K558-sm 9859918 ASAEADGkLIQDSRR activity, induced; intracellular localization 19638400 1 0 0 sumoylation is linked to its GTPase activity cycle, and influenced by DRP1 localization -NFKB1 NFkB-p105 DNA-binding; Transcription factor P19838 4790 4q24 human S80-p 1869465801 SSEKNKKsYPQVKIC RHD_DNA_bind molecular association, regulation transcription, altered DNA(DISRUPTS) 31598684 1 0 0 -NFE2L2 NRF2 DNA-binding; Transcription factor Q16236 4780 2q31.2 human R437-me 56423804 LPVSPGHrKTPFTKD molecular association, regulation transcription, induced DNA(INDUCES) 27183873 1 0 0 -H3c1 H3 DNA-binding P68433 360198 13|13 A3.1 mouse K9-m2 459006 RTKQTARkSTGGKAP Histone molecular association, regulation cell cycle regulation; cell growth, induced; apoptosis, induced; chromatin organization, altered; transcription, inhibited; transcription, altered CBX1(INDUCES) 11242053; 17823087; 18039862; 19910458; 20067909; 20561915; 35293595 119 21 0 H3K9m3 leads to heterochromatin and proliferation -MAPT Tau iso8 ACETYLTRANSFERASE; Acetyltransferase; Cytoskeletal P10636-8 4137 17q21.31 human S214-p 447929 GSRSRTPsLPTPPTR molecular association, regulation; intracellular localization; protein conformation; phosphorylation cytoskeletal reorganization WWOX(INDUCES); APOE(INDUCES); TUBB(INDUCES) 10090741; 15126504; 15364924; 16982696; 16987243; 18725412; 20550628; 20639351; 20679343; 33890983 63 24 42 -TRADD TRADD Adaptor/scaffold; Apoptosis Q15628 8717 16q22.1 human S215-p 20831309 PVVNRPLsLKDQQTF molecular association, regulation transcription, induced FADD(INDUCES); TNF-R1(INDUCES); RIP(INDUCES) 21724995 1 0 0 -SPP1 osteopontin Secreted; Secreted, signal peptide P10451 6696 4q22.1 human S117-p 455736 DVDDTDDsHQSDESH Osteopontin molecular association, regulation; activity, inhibited Other(INDUCES) 19775205 1 4 0 peptide with phosphorylated S117, S120, S123, S126 and S129 has increased binding to hydroxyapatite, and inhibits bone mineralization in vivo and in vitro -Sod2 SOD2 EC 1.15.1.1; Mitochondrial; Oxidoreductase P09671 20656 17 A1|17 8.75 cM mouse K130-ac 7248076 RDFGSFEkFKEKLTA Sod_Fe_C intracellular localization; protein conformation 28433661 2 10 12 mediates pentameric SOD2 deaggregation; importation into mitochondria -GFAP GFAP Cytoskeletal F1RR02 396562 pig S34-p 449621 LGPGPRLsLARMPPP Filament_head cell cycle regulation 1379174 6 3 0 -CASP7 CASP7 Apoptosis; EC 3.4.22.60; Endoplasmic reticulum; Mitochondrial; Protease P55210 840 10q25.3 human S30-p 12069580 DAKPDRSsFVPSLFS activity, inhibited cell growth, induced; apoptosis, inhibited CASP9(DISRUPTS) 21555521; 27889207 2 1 1 -NBN NBS1 Cell cycle regulation; DNA repair, damage O60934 4683 8q21.3 human K665-ac 487513 EFRSLVIkNSTSRNP phosphorylation cell cycle regulation; apoptosis, induced 17612497 2 1 0 inhibits phosphorylation at S343 -EIF2AK2 PKR EC 2.7.10.2; EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, Other; Protein kinase, Ser/Thr (non-receptor); Protein kinase, tyrosine (non-receptor); Translation P19525 5610 2p22.2 human T255-p 448086 DLPDMKEtKYTVDKR enzymatic activity, induced 11152499 2 0 0 -NTRK1 TrkA EC 2.7.10.1; KINASE; Kinase, protein; Membrane protein, integral; Oncoprotein; Protein kinase, TK; Protein kinase, tyrosine (receptor) P04629 4914 1q23.1 human Y757-p 449758 RACPPEVyAIMRGCW PK_Tyr_Ser-Thr activity, induced 16319926 3 0 0 mutation of site abolished phosphorylation and NGF-induced sensitization of VR1 -Tiam1 TIAM1 GEF; GEF, Rac/Rho; Motility/polarity/chemotaxis; Oncoprotein Q60610 21844 16 C3.3|16 51.5 cM mouse S231-p 468938 STCQRANsLGDLYAQ molecular association, regulation 14-3-3 zeta(INDUCES) 19899799 2 43 6 -Cyth1 cytohesin 1 GEF; GEF, ARF; Motility/polarity/chemotaxis P97694 116691 10q32.2-q32.3 rat Y382-p 464074 AISRDPFyEMLAARK activity, induced 23012656 2 0 147 myelination -STAT5B STAT5B DNA-binding; Oncoprotein; Transcription factor P51692 6777 17q21.2 human K694-ac 62484405 PCESATAkAVDGYVK phosphorylation transcription, induced 23980167 1 0 0 increases pSTAT5B at Y699 -FOXO1 FOXO1A DNA-binding; Nuclear receptor co-regulator; Oncoprotein; Transcription factor Q12778 2308 13q14.11 human S325-p 449114 SSNASTIsGRLSPIM intracellular localization 11980723; 14664696 5 1 0 -SSBP3 SSBP3 Cell cycle regulation; DNA-binding; Transcription regulation Q9BWW4 23648 1p32.3 human Y23-p 1806900 AREKLALyVYEYLLH activity, induced; intracellular localization transcription, induced 18080319 1 0 0 -MAP3K7 TAK1 EC 2.7.11.25; KINASE; Kinase, protein; Protein kinase, Ser/Thr (non-receptor); Protein kinase, TKL O43318 6885 6q15 human K72-ub 25698801 IESESERkAFIVELR PK_Tyr_Ser-Thr protein degradation transcription, inhibited 22406003 1 1 0 -Sod2 SOD2 EC 1.15.1.1; Mitochondrial; Oxidoreductase P09671 20656 17 A1|17 8.75 cM mouse K132-ac 3852802 FGSFEKFkEKLTAVS Sod_Fe_C enzymatic activity, altered 28433661 0 3 7 -AKT1 Akt1 EC 2.7.11.1; KINASE; Kinase, protein; Oncoprotein; Protein kinase, AGC; Protein kinase, Ser/Thr (non-receptor) P31749 207 14q32.33 human K64-m3 1883432305 VAQCQLMkTERPRPN carcinogenesis, induced; signaling pathway regulation 35184652 1 0 0 EZH2 promotes HCC cell tumorigenesis and chemoresistance via the miR-381/ SETDB1/AKT pathway -IRF5 IRF5 DNA-binding; Transcription factor Q13568 3663 7q32.1 human Y313-p 57775901 PSDKQRFyTNQLLDV IRF-3 molecular association, regulation; ubiquitination transcription, inhibited LYN(INDUCES) 27521268 1 1 0 inhibition of IRF5 activation by Lyn requires their physical Interaction, Lyn inhibits IRF5 ubiquitination and phosphorylation by protecting IRF5 from each of PTM enzymes -Grb14 GRB14 Adaptor/scaffold O88900 58844 3q21 rat Y345-p 20745205 LKYGMQLyQNYMHPS molecular association, regulation PTP1B(INDUCES) 21791607 1 0 0 -FOXP3 FOXP3 C2H2-type zinc finger protein; Cell cycle regulation; DNA-binding; Transcription factor Q9BZS1 50943 Xp11.23 human K356-ub 56786301 AILEAPEkQRTLNEI Forkhead protein degradation; ubiquitination 27432879 1 1 0 -PRKDC DNAPK DNA repair, damage; EC 2.7.11.1; KINASE; Kinase, protein; Nucleolus; Protein kinase, Ser/Thr (non-receptor); Protein kinase, atypical P78527 5591 8q11.21 human S2612-p 448711 MFVETQAsQGTLQTR DNAPKcs_CC5 molecular association, regulation; protein conformation DNA repair, induced; chromatin organization, altered; cell growth, altered DNA(DISRUPTS) 17189255; 24687855 6 21 56 increases survival in ionizing radiation and repairing double strand DNA breaks; cell survival induced, induces removal of cisplatin adducts from DNA, induces end processing -KAT2B PCAF ACETYLTRANSFERASE; Acetyltransferase; EC 2.3.1.48; Nuclear receptor co-regulator Q92831 8850 3p24.3 human K430-ac 458986 ANPGEKRkMTDSHVL enzymatic activity, induced 12888487 1 0 0 in vitro -RPS6KB2 P70S6KB EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, AGC; Protein kinase, Ser/Thr (non-receptor); Translation Q9UBS0 6199 11q13.2 human S473-p 450071 PPSGTKKsKRGRGRP intracellular localization 12529391 1 0 0 -APP APP Apoptosis; Cell surface; Membrane protein, integral; Receptor, misc.; Transcription factor P05067 351 21q21.3 human C187-pa 62489907 RGVEFVCcPLAEESD APP_Cu_bd molecular association, regulation APP(INDUCES) 27875558 1 0 0 palAPP dimerizes ~4.5 times more efficiently -WRN WRN Cell cycle regulation; DNA repair, damage; DNA-binding; EC 3.6.4.12; Helicase; Nucleolus Q14191 7486 8p12 human S1133-p 10940893 KKSIMVQsPEKAYSS molecular association, regulation; intracellular localization DNA repair, induced MRE11A(INDUCES) 27634057 3 23 1 association of WRN with the MRE11 complex and MRE11 foci-formation after replication-dependent DSBs -BCAR1 P130Cas Adaptor/scaffold; Motility/polarity/chemotaxis P56945 9564 16q23.1 human Y664-p 448399 EGGWMEDyDYVHLQG CAS_C carcinogenesis, induced; cell motility, induced; cell adhesion, induced; cytoskeletal reorganization 22084245 6 2 24 P130Cas phosphorylation is important in development of peripheral adhesion complexes, oncogenic signaling, and cell migration. -MT-CO1 COX1 EC 1.9.3.1; Energy Metabolism - oxidative phosphorylation; Membrane protein, integral; Membrane protein, multi-pass; Mitochondrial; Oxidoreductase P00396 cow Y304-p 454437 MDVDTRAyFTSATMI COX1; TM enzymatic activity, inhibited signaling pathway regulation 15557277; 18534980; 21771582 3 2 0 regualtion of electron transport chain -TSC1 TSC1 Motility/polarity/chemotaxis; Tumor suppressor Q92574 7248 9q34.13 human T417-p 450279 SLPQATVtPPRKEER Hamartin molecular association, regulation; intracellular localization apoptosis, altered TSC2(INDUCES); HSP70(INDUCES) 20006582 2 0 0 -Runx2 AML3 iso5 DNA-binding; Transcription factor Q08775-5 12393 17 B3|17 21.33 cM mouse S301-p 10892804 DPRQAQSsPPWSYDQ activity, induced; acetylation; intracellular localization carcinogenesis, induced; cell differentiation, induced; cell motility, induced; chromatin organization, altered; transcription, induced 20484411; 22337141; 25867060; 26206105; 27341689 10 2 0 -Scnn1b ENaC-beta Channel, sodium; Membrane protein, integral; Membrane protein, multi-pass; Transporter, ion channel P37090 24767 1q36 rat T613-p 451219 QTLPIPGtPPPNYDS molecular association, regulation; intracellular localization; activity, inhibited NEDD4L(DISRUPTS) 11805112; 16476738; 29397423 6 1 0 enhances Nedd4-2-mediated ENaC retrieval from the plasma membrane; negatively regulates expression of ENaC at the plasma membrane; necessary for inhibitory effect of Nedd4-2 on ENaC function -KRT18 K18 Cytoskeletal; Nucleolus P05783 3875 12q13.13 human S53-p 447734 ISVSRSTsFRGGMGS molecular association, regulation; protein processing; intracellular localization cell motility, induced; apoptosis, induced; cytoskeletal reorganization; transcription, altered ITGB1(INDUCES) 10623656; 15368451; 16424149; 17084817; 17898082; 25537517; 32365802; 8522590 17 12 14 EGF stimulated, membrane ruffling, metastasis; regulates expression of REG3C and REG3G; implicated in reorganization of intermediate filaments; S52 phosphorylation increases during S and G2/M stages of the cell cycle. Phosphorylated S52 is preferentially found in reorganized filaments and in specific cellular domains. ; induces solubility of keratin filaments and inhibits polymerization -KIF20A KIF20A Microtubule-binding; Motor O95235 10112 5q31.2 human T198-p 32007200 LQGQLHPtPDLKPLL Kinesin molecular association, regulation; intracellular localization; protein conformation cell cycle regulation INCENP(DISRUPTS) 24656812 1 0 0 favours solubility, inhibits microtubule binding -Panx1 PANX1 Cell adhesion; Membrane protein, integral; Membrane protein, multi-pass P60570 315435 8q12 rat S394-p 14577460 TKGEDQGsQRMDFKD activity, induced; receptor internalization, induced; protein conformation 34301850 1 1 0 -H3F3C H3 DNA-binding P84229 427887 chicken K4-m3 1458621 ____ARTkQTARKST Histone chromatin organization, altered; transcription, induced 17913747; 23028147 178 10 0 -IKBKG IKKG Adaptor/scaffold; Protein kinase, regulatory subunit Q9Y6K9 8517 Xq28 human S31-p 449036 QDVLGEEsPLGKPAM protein stabilization transcription, induced 27929056 2 4 9 -Pik3ap1 BCAP Adaptor/scaffold Q9EQ32 83490 19|19 C3 mouse Y264-p 12520500 CETTVSYyTDMEEIG DBB molecular association, regulation cell differentiation, altered PIK3R1(INDUCES) 18025150 1 0 0 regulate Akt activation and B-cell differentiation through binding to PI3KR1 -TSC2 TSC2 Cell cycle regulation; GAP; GAP, misc.; Nuclear receptor co-regulator; Tumor suppressor P49815 7249 16p13.3 human R1459-me 1877221603 SPSGLRPrGYTISDS protein stabilization; phosphorylation signaling pathway regulation 33273660 1 0 0 mTOR activity; inhibits phosphorylation -ITCH ITCH iso2 EC 6.3.2.-; EC 6.3.2.19; Ligase; UBIQUITIN LIGASE; Ubiquitin conjugating system; Ubiquitin ligase Q96J02-2 83737 20q11.22 human T222-p 459624 PSRPPPPtPRRPASV enzymatic activity, induced 27203743 3 0 0 HER3 ubiquitination and degradation in cancer cells -FOXO3 FOXO3A Autophagy; DNA-binding; Oncoprotein; Transcription factor O43524 2309 6q21 human T32-p 448602 QSRPRSCtWPLQRPE activity, induced; molecular association, regulation; intracellular localization; activity, inhibited signaling pathway regulation; transcription, altered 14-3-3 beta(INDUCES) DNA(INDUCES) 18593906; 20110348; 21750219; 26376801; 27451907 74 8 91 Regulation of PI3K/mTOR signaling; cell viability induced -MYLK smMLCK EC 2.7.11.18; KINASE; Kinase, protein; Protein kinase, CAMK; Protein kinase, Ser/Thr (non-receptor) P11799 396445 chicken S149-p 17555039 PPVEHRPsIWGESPP molecular association, regulation ACTB(DISRUPTS) 26567572 1 3 0 in vitro the single S149D mutation reduced N27-157 association with F-actin -Pik3r3 PIK3R3 Kinase, lipid; Motility/polarity/chemotaxis Q64143 18710 4|4 D1 mouse Y199-p 450746 SKEYDRLyEEYTRTS PI3K_P85_iSH2 cell cycle regulation; carcinogenesis, induced; cell motility, induced; cell growth, induced; apoptosis, inhibited 36310322 7 28 746 -Mitf MITF DNA-binding; Oncoprotein; Transcription factor Q08874 17342 6 D3|6 45.05 cM mouse K423-sm 3590700 DLVNRIIkQEPVLEN DUF3371 transcription, inhibited 16029420 3 1 0 -PRKACA PKACA EC 2.7.11.11; KINASE; Kinase, protein; Protein kinase, AGC; Protein kinase, Ser/Thr (non-receptor) P17612 5566 19p13.12 human T198-p 448459 RVKGRTWtLCGTPEY Pkinase protein stabilization; protein conformation; phosphorylation; enzymatic activity, induced endocytosis, inhibited 15481030; 16026785; 22154087; 22493239; 34497151 34 48 277 induces RhoA phosphorylation -Rps6kb2 P70S6KB EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, AGC; Protein kinase, Ser/Thr (non-receptor); Translation Q9Z1M4 58988 19|19 A mouse S423-p 455991 SSPRTPIsPLKFSPF phosphorylation 17980619 2 18 44 -Klf4 KLF4 C2H2-type zinc finger protein; DNA-binding; Transcription factor Q60793 16600 4 B3|4 29.76 cM mouse K275-sm 14988613 PRMCPKIkQEAVPSC cell growth, inhibited; transcription, induced 20584900 2 0 0 -H2bc15 H2B DNA-binding P10853 319187 13|13 A3.1 mouse K120-ub 465519 EGTKAVTkYTSSK__ cell cycle regulation; cell differentiation, altered; cell differentiation, induced; transcription, induced; transcription, inhibited; transcription, altered 32341358; 32797353 35 21 138 -SOX4 SOX4 DNA-binding; Transcription factor Q06945 6659 6p22.3 human K95-ac 49182101 EISKRLGkRWKLLKD HMG_box chromatin organization, altered; cell differentiation, induced; transcription, induced 26291311 1 0 0 -Plcg1 PLCG1 Carbohydrate Metabolism - inositol phosphate; EC 3.1.4.11; Motility/polarity/chemotaxis; Phospholipase Q62077 18803 2 H2|2 80.97 cM mouse Y771-p 448575 IGTAEPDyGALYEGR molecular association, regulation; protein conformation cell cycle regulation; cell motility, altered PLCG1(INDUCES) 18515860; 26687682 16 41 552 -MAOA MAOA Amino Acid Metabolism - arginine and proline; Amino Acid Metabolism - glycine, serine and threonine; Amino Acid Metabolism - histidine; Amino Acid Metabolism - phenylalanine; Amino Acid Metabolism - tryptophan; Amino Acid Metabolism - tyrosine; EC 1.4.3.4; Membrane protein, integral; Oxidoreductase; Xenobiotic Metabolism - drug metabolism - cytochrome P450 P21397 4128 Xp11.3 human S209-p 9726600 GGTTRIFsVTNGGQE Amino_oxidase protein degradation; enzymatic activity, inhibited; protein conformation 19645722; 19650872 2 0 0 -RPA2 RFA2 DNA replication P15927 6118 1p35.3 human S8-p 470083 MWNSGFEsYGSSSYG molecular association, regulation; intracellular localization cell cycle regulation; DNA repair, induced; carcinogenesis, inhibited; apoptosis, induced; transcription, altered; cell growth, altered p53(INDUCES); WRN(INDUCES) 17035231; 18003706; 18289945; 21107010; 21731742; 29875999; 30573684; 32989256; 37409248 48 2 0 -RORA RORA DNA-binding; Nuclear receptor P35398 6095 15q22.2 human S35-p 12613703 ETPLNQEsARKSEPP molecular association, regulation cell motility, altered; cell growth, altered CTNNB1(INDUCES) DNA(INDUCES) 20122401 1 1 0 downregulates the Wnt signaling -MAP2K2 MEK2 EC 2.7.12.2; KINASE; Kinase, protein; Protein kinase, STE; Protein kinase, dual-specificity (non-receptor) P36507 5605 19p13.3 human S216-p 455802 KLCDFGVsGQLIDSM Pkinase enzymatic activity, inhibited 12506122 3 2 3 -UBR5 UBR5 EC 6.3.2.-; EC 6.3.2.19; Ligase; Nuclear receptor co-regulator; UBIQUITIN LIGASE; Ubiquitin conjugating system; Ubiquitin ligase O95071 51366 8q22.3 human T637-p 3952394 PYKRRRStPAPKEEE translation, inhibited 28559278 1 5 10 translational repression of TRAF3 mRNA -Npas4 NPAS4 DNA-binding Q8BGD7 225872 19|19 A mouse T611-p 1871095703 LVPEGLLtPEASPVK molecular association, regulation neural plasticity; transcription, induced CBP(INDUCES) 31801086 1 1 0 -Prkcd PKCD EC 2.7.11.13; KINASE; Kinase, protein; Nuclear receptor co-regulator; Protein kinase, AGC; Protein kinase, Ser/Thr (non-receptor); Protein kinase, tyrosine (non-receptor); Tumor suppressor P28867 18753 14 B|14 18.82 cM mouse Y155-p 447575 IKQAKIHyIKNHEFI protein degradation; molecular association, regulation; intracellular localization cell cycle regulation; cell motility, induced; apoptosis, induced; cell adhesion, induced; apoptosis, inhibited; cell growth, altered KPNA2(INDUCES) 10783308; 10945993; 15774464; 18059334; 21865164; 30095599 11 0 0 induces O2 production and NET formation, increases permeability, regulates inflammation; PKCD-induced apoptosis -ASF1A ASF1A DNA repair, damage; Histone-binding Q9Y294 25842 6q22.31 human S192-p 12671900 GWSTSENsLNVMLES molecular association, regulation; protein stabilization; ubiquitination DNA repair, induced; chromatin organization, altered MMS22L(INDUCES); CAF-1A(INDUCES); H3(INDUCES); H3 iso3(INDUCES); H4(INDUCES) DNA(INDUCES) 20016786; 29478807 2 3 0 -MAP3K11 MLK3 EC 2.7.11.25; KINASE; Kinase, protein; Protein kinase, Ser/Thr (non-receptor); Protein kinase, TKL Q16584 4296 11q13.1 human T738-p 4271419 EEEPRGGtVSPPPGT phosphorylation; enzymatic activity, induced carcinogenesis, induced; cell motility, induced; cell growth, induced; apoptosis, inhibited 34511598 1 4 0 induces c-Jun phosphorylation -Trpv5 TRPV5 Channel, cation; Membrane protein, integral; Membrane protein, multi-pass; Motility/polarity/chemotaxis Q9XSM3 rabbit T709-p 4710939 WEILRRNtLGHLNLG activity, induced 19423690 3 1 0 -MAFG MAFG Cell cycle regulation; DNA-binding O15525 4097 17q25.3 human K60-ac 458965 KQRRRTLkNRGYAAS bZIP_Maf molecular association, regulation DNA(INDUCES) 11154691 1 0 0 -NPFFR2 NPFFR2 GPCR, family 1; Membrane protein, integral; Membrane protein, multi-pass; Receptor, GPCR Q9Y5X5 10886 4q13.3 human S500-p 36533414 ETLLYRKsAEKPQQE receptor internalization, induced 25326382 1 1 0 -ACOT4 ACOT4 EC 3.1.2.2; Hydrolase; Lipid Metabolism - unsaturated fatty acid biosynthesis Q8N9L9 122970 14q24.3 human S392-p 1871177703 GGEPRAHsKAQEDAW BAAT_C protein stabilization; molecular association, regulation carcinogenesis, induced HSP70(DISRUPTS) 33148467 1 1 0 -LOC100399755 GNRHR2 GPCR, family 1; Membrane protein, integral; Membrane protein, multi-pass; Receptor, GPCR Q95MG6 100399755 marmoset S338-p 454393 HQELSMDsSREEGSR receptor internalization, altered 15205374 1 0 0 -STXBP5L STXBP5L Q9Y2K9 9515 3q13.33 human S823-p 4724310 SRSSSISsIDKDSKE Lgl_C protein degradation 25002582 1 6 9 ; in a multiple residue S->D mutant -CDCA2 CDCA2 Q69YH5 157313 8p21.2 human S977-p 10424830 EPGKRRKsFCISTLA molecular association, regulation cell cycle regulation; chromatin organization, altered PPP1CC(DISRUPTS) 32938714 1 10 3 regulation chromosome condesation rate -ANLN anillin iso2 Actin-binding; Motility/polarity/chemotaxis Q9NQW6-2 54443 7p14.2 human S635-p 15228550 EDRDLLYsIDAYRSQ intracellular localization cell cycle regulation 28081137 1 1 5 anillin recruitment to the equatorial cortex at anaphase -CROCC CROCC iso2 Cytoskeletal Q5TZA2-2 9696 1p36.13 human S763-p 14159744 APRPVPGsPARDAPA carcinogenesis, induced; cell growth, induced; signaling pathway regulation 22610972 1 14 4 -MAP2K1 MEK1 EC 2.7.12.2; KINASE; Kinase, protein; Protein kinase, STE; Protein kinase, dual-specificity (non-receptor) Q02750 5604 15q22.31 human T286-p 448286 VEGDAAEtPPRPRTP Pkinase enzymatic activity, inhibited; phosphorylation signaling pathway regulation 12609978; 25971971; 8114697 8 6 16 induces phosphorylation of T292 by CDK5, inhibits ERK phosphorylation, regulates Ras/MEK/ERK signaling -Nr0b2 NR0B2 Nuclear receptor; Nuclear receptor co-regulator; Transcription, coactivator/corepressor Q62227 23957 4 D2.3|4 66.25 cM mouse K123-ub 7596702 PVPSILKkILLEEAS Hormone_recep protein degradation 19390091 1 0 0 -ESR1 ER-alpha DNA-binding; Nuclear receptor; Transcription factor P03372 2099 6q25.1-q25.2 human K266-m1 31094523 RRGGRMLkHKRQRDD acetylation transcription, inhibited 24101509 1 1 0 inhibits acetylation at ER-alpha K266/268 -Abraxas2 ABRAXAS2 Ubiquitin conjugating system Q3TCJ1 109359 7|7 F3 mouse Y377-p 3196742 EESDDSDyENLIDPA molecular association, regulation LNK(INDUCES) 30755420 1 4 4 interaction with LNK further regulates LNK interaction with BRISC -CAMK2A CAMK2A EC 2.7.11.17; KINASE; Kinase, protein; Protein kinase, CAMK; Protein kinase, Ser/Thr (non-receptor) Q9UQM7 815 5q32 human T253-p 451571 DLINKMLtINPSKRI Pkinase cytoskeletal reorganization 20060891 8 5 1 -Wasl N-WASP Adaptor/scaffold; Motility/polarity/chemotaxis O08816 682507 4q22 rat T196-p 23003801 KAKKKRLtKADIGTP molecular association, regulation; protein conformation cytoskeletal reorganization 22250195 1 0 0 inhibits actin polymerization in vitro; inhibits the filopodia promoting activity of N-WASP -E2F1 E2F1 DNA-binding; Transcription factor Q01094 1869 20q11.22 human K125-ac 459019 GVKSPGEkSRYETSL protein stabilization; molecular association, regulation apoptosis, induced; transcription, induced DNA(INDUCES) 10675335; 10753885; 22184068 3 0 0 etoposide-induced DNA damage, pRB-free form of E2F1, does not bind to pRB; both complexes act in parallel to induce transcription of proapoptotic genes -CDK1 CDK1 Cell cycle regulation; EC 2.7.11.22; EC 2.7.11.23; KINASE; Kinase, protein; Motility/polarity/chemotaxis; Protein kinase, CMGC; Protein kinase, Ser/Thr (non-receptor) P06493 983 10q21.2 human K33-ac 461140 TGQVVAMkKIRLESE Pkinase enzymatic activity, inhibited cell cycle regulation CCNB1(DISRUPTS) 30974121 2 5 133 blocks cell-cycle progression in S. pombe -Vgll4 VGLL4 Transcription, coactivator/corepressor Q80V24 232334 6|6 E3 mouse K216-ac 59149206 HFRRSLGkNYKEPEP VGLL4 molecular association, regulation cell cycle regulation; cell growth, induced; transcription, induced; signaling pathway regulation TEAD1(DISRUPTS) 27720608 1 1 0 regulates Hippo-Yap signaling -EGFR EGFR EC 2.7.10.1; KINASE; Kinase, protein; Membrane protein, integral; Oncoprotein; Protein kinase, TK; Protein kinase, tyrosine (receptor) P00533 1956 7p11.2 human K713-ub 1065309 ILKETEFkKIKVLGS PK_Tyr_Ser-Thr receptor recycling, inhibited; protein degradation 16543144; 17940017 2 2 0 -EZH2 EZH2 EC 2.1.1.43; METHYLTRANSFERASE; Methyltransferase; Methyltransferase, protein lysine Q15910 2146 7q36.1 human K348-ac 40477503 ERIKTPPkRPGGRRR protein stabilization; molecular association, regulation; phosphorylation carcinogenesis, induced; cell motility, induced; transcription, inhibited DNA(INDUCES) 25800736; 31948940 2 1 0 inhibits phosphorylation at T345 and T487 -CTNNB1 CTNNB1 Actin-binding; Cell adhesion; Motility/polarity/chemotaxis; Nuclear receptor co-regulator; Oncoprotein; Transcription factor P35222 1499 3p22.1 human K394-ub 27850504 NLSDAATkQEGMEGL protein stabilization transcription, induced 22705350 1 0 0 -MET Met EC 2.7.10.1; KINASE; Kinase, protein; Membrane protein, integral; Oncoprotein; Protein kinase, TK; Protein kinase, tyrosine (receptor) P08581 4233 7q31.2 human Y1194-p 473312 QVAKGMKyLASKKFV PK_Tyr_Ser-Thr protein conformation; enzymatic activity, induced 14559966 1 0 2 -Gli2 GLI2 C2H2-type zinc finger protein; Oncoprotein; Transcription factor Q0VGT2 14633 1 E2.3|1 52.17 cM mouse S789-p 15410478 QLQERRDsSTSTMSS sumoylation 22549777 1 0 3 -OSMR OSMR Membrane protein, integral; Receptor, cytokine Q99650 9180 5p13.1 human Y861-p 458403 ICFENLTyNQAASDS molecular association, regulation; phosphorylation transcription, altered; cell growth, altered SHC1(INDUCES) 11016927; 15935618 3 0 6 required for ERK1/2, p38 and JNK activation; ERK activation -Irs1 IRS1 Adaptor/scaffold; Motility/polarity/chemotaxis P35570 25467 9q34 rat S662-p 2352501 PNGYMMMsPSGSCSP enzymatic activity, inhibited 8626671 2 1 6 The serine phosphorylation sites negatively regulate PI3 kinase activity associated with IRS-1. -Kcna2 Kv1.2 Channel, potassium; Membrane protein, integral; Membrane protein, multi-pass P63142 25468 2q34 rat S441-p 1818103 SCPKIPSsPDLKKSR intracellular localization 18056633 1 7 0 -PLK1 PLK1 EC 2.7.11.21; KINASE; Kinase, protein; Protein kinase, Other; Protein kinase, Ser/Thr (non-receptor) P53350 5347 16p12.2 human S326-p 5393500 LTIPPRFsIAPSSLD enzymatic activity, induced cell cycle regulation 18695677 1 2 0 -BAD BAD Apoptosis Q92934 572 11q13.1 human S118-p 447863 GRELRRMsDEFVDSF Bcl-2_BAD molecular association, regulation apoptosis, altered; apoptosis, inhibited 14-3-3 beta(INDUCES); Bcl-xL(DISRUPTS) 18794113; 21419810; 21849418 47 63 166 -CALD1 Caldesmon Actin-binding P12957 373965 chicken S672-p 456706 EGVRNIKsMWEKGNV Caldesmon molecular association, regulation Calmodulin(DISRUPTS) 20858431 5 0 0 -PPDPF PPDPF Unknown function Q9H3Y8 79144 20q13.33 human Y16-p 1883583902 SLVATHDyYRRRLGS protein stabilization; molecular association, regulation carcinogenesis, induced; cell growth, induced CK1A(INDUCES) 37477088 1 0 0 -FZD3 FZD3 GPCR, Fz/Smo family; Membrane protein, integral; Membrane protein, multi-pass; Receptor, GPCR Q9NPG1 7976 8p21.1 human T598-p 1869636102 RSRDGRYtPCSYRGM molecular association, regulation signaling pathway regulation VANGL2(DISRUPTS) 32641508 1 1 0 regulation of axonal PCP signaling and growth cone communications -RARA RARA DNA-binding; Nuclear receptor; Oncoprotein; Transcription factor P10276 5914 17q21.2 human S77-p 455459 EIVPSPPsPPPLPRI activity, induced; protein degradation; molecular association, regulation; activity, inhibited; protein conformation cell cycle regulation; carcinogenesis, induced; RNA stability, induced; transcription, induced; signaling pathway regulation; transcription, altered; apoptosis, inhibited; autophagy, inhibited; transcription, inhibited N-CoR1(INDUCES); RXRA(INDUCES); SRC-3(DISRUPTS); PIN1(INDUCES); CCNH(INDUCES) DNA(INDUCES) 11955452; 12054865; 15670742; 16769902; 19078967; 19917671; 21297158; 25849135; 33902658 11 2 0 -RAF1 RAF1 EC 2.7.11.1; KINASE; Kinase, protein; Oncoprotein; Protein kinase, Ser/Thr (non-receptor); Protein kinase, TKL P04049 5894 3p25.2 human T481-p 1811400 IFLHEGLtVKIGDFG PK_Tyr_Ser-Thr enzymatic activity, induced 16093354 1 2 0 mutation of T481 is less profound of an effect. B-Raf S579 shows similar effects to Raf1 S471.; Mutation of Raf1 S471 abolishes kinase activity and EGF-induced activity -Dab1 DAB1 iso2 Adaptor/scaffold P97318-2 13131 4 C6|4 47.79 cM mouse S400-p 479417 TNDSARSsPQSDKPR molecular association, regulation; intracellular localization; phosphorylation signaling pathway regulation SH3KBP1(DISRUPTS) 16529723; 23506116 3 0 0 regulates trafficking of reelin receptors and hence Reelin signaling pathway; inhibits tyrosine phosphorylation -Pea15 PEA-15 Apoptosis; Motility/polarity/chemotaxis Q62048 18611 1 H3|1 79.54 cM mouse S116-p 450281 KDIIRQPsEEEIIKL molecular association, regulation cell cycle regulation ERK1(DISRUPTS); ERK2(DISRUPTS) 15917297 15 95 1092 -STAT1 STAT1 DNA-binding; Transcription factor P42224 6772 2q32.2 human T749-p 56654462 EFDSMMNtV______ molecular association, regulation RNA stability, induced; transcription, induced DNA(INDUCES) 32209697 1 1 0 enhances binding to promoter of ARID5A and IL12B -SMAD4 SMAD4 DNA-binding; Nuclear receptor co-regulator; Transcription, coactivator/corepressor Q13485 4089 18q21.2 human T269-p 36694100 HNSTTTWtGSRTAPY protein degradation; molecular association, regulation; ubiquitination carcinogenesis, inhibited; transcription, inhibited; signaling pathway regulation BTRC(INDUCES) 25373906 1 0 0 -Ciz1 CIZ1 Cell cycle regulation Q8VEH2 68379 2|2 B mouse T293-p 15418576 TAPKQTQtPDRLPEP molecular association, regulation; activity, inhibited cell cycle regulation CCNA1(DISRUPTS) 25736292 1 1 1 phosphorylation of T293 and T192, T144 are required for interaction with the cyclinA-CDK2 complex and directing it to chromatin -Cdk16 CDK16 Cell cycle regulation; EC 2.7.11.22; KINASE; Kinase, protein; Motility/polarity/chemotaxis; Protein kinase, CMGC; Protein kinase, Ser/Thr (non-receptor) Q04735 18555 X A1.3|X 16.18 cM mouse S146-p 48921815 PIFDKPLsRRLRRVS molecular association, regulation; enzymatic activity, altered CCNYL1(INDUCES) 26305884 1 1 0 -FAAP20 FAAP20 iso2 Q6NZ36 199990 1p36.33 human K152-ac 1870026101 RSCPMCQkEFAPRLT UBZ_FAAP20 protein stabilization; ubiquitination 32763975 1 0 0 antagonizes FAAP20 ubiquitination and degradation -MYLK smMLCK EC 2.7.11.18; KINASE; Kinase, protein; Protein kinase, CAMK; Protein kinase, Ser/Thr (non-receptor) Q15746 4638 3q21.1 human S145-p 41411900 KTLGDRFsAPAVETR molecular association, regulation; protein conformation 14-3-3 beta(INDUCES) 26111161 2 1 0 minor local conformational changes -GSK3B GSK3B EC 2.7.11.1; EC 2.7.11.26; KINASE; Kinase, protein; Protein kinase, CMGC; Protein kinase, Ser/Thr (non-receptor) P49841 2932 3q13.33 human K15-ac 1876813500 TSFAESCkPVQQPSA protein stabilization; enzymatic activity, induced cytoskeletal reorganization 33107080; 35339896 2 1 0 overexpressing tau increases GSK-3b acetylation with inhibited ubiquitination and proteolysis, causes memory impairment and synaptic dysfunction, exacerbates tau hyperphosphorylation ; regulation of meiotic assembly of meiotic apparatus in mouse oocytes, mutant K15R alleviates the meiotic defects in oocytes from diabetic mice -ANPEP CD13 EC 3.4.11.2; Membrane protein, integral; Other Amino Acids Metabolism - glutathione; Protease; Receptor, misc. P15144 290 15q26.1 human Y6-p 29570700 __MAKGFyISKSLGI activity, induced; molecular association, regulation; receptor recycling, induced; intracellular localization; enzymatic activity, induced cell motility, induced; cell adhesion, induced; cytoskeletal reorganization ARF6(INDUCES); ACTN1(INDUCES); IQGAP1(INDUCES) 23997214; 31040262 2 0 0 Beta-1 integrin recycling to the cell surface, induce ARF6 activation; activation of the Src, FAK, and ERK kinases -STRAP STRAP Adaptor/scaffold; RNA splicing; UBIQUITIN LIGASE; Ubiquitin ligase Q9Y3F4 11171 12p12.3 human K148-ac 1876755701 GHTSGIKkALWCSED WD40 protein stabilization transcription, induced 32527012 1 0 0 upregulation and stabilization of p53 as well as its targets -GABBR2 GABBR2 GPCR, family 3; Membrane protein, integral; Membrane protein, multi-pass; Receptor, GPCR O75899 9568 9q22.33 human K772-ub 54191604 NQKKEDSkTSTSVTS protein degradation; ubiquitination 24114844; 26817839 2 0 0 -LHX3 LHX3 DNA-binding; Transcription factor Q9UBR4 8022 9q34.3 human S234-p 455298 YFRNMKRsRGGSKSD activity, induced transcription, induced 15517599 1 0 0 no change in binding to DNA or to certain proteins (NLI, PIT1, or MRG1) -DEPTOR DEPTOR Apoptosis Q8TB45 64798 8q24.12 human S298-p 4723873 SSSPTLSsSPPVLCN protein degradation; molecular association, regulation carcinogenesis, induced; apoptosis, inhibited; signaling pathway regulation mTOR(DISRUPTS) 19446321 3 3 1 PI3K-Akt signaling -MAP3K7 TAK1 EC 2.7.11.25; KINASE; Kinase, protein; Protein kinase, Ser/Thr (non-receptor); Protein kinase, TKL O43318 6885 6q15 human T344-p 969328000 QVPATNDtIKRLESK molecular association, regulation IKKG(INDUCES) 29511289 1 1 0 -ECE1 ECE1 iso3 Cell surface; EC 3.4.24.71; Membrane protein, integral; Protease; Vesicle P42892-3 1889 1p36.12 human T9-p 14159846 MSTYKRAtLDEEDLV protein stabilization cell motility, induced 26543229 1 7 8 colon cancer cell invasion. -SLC30A2 SLC30A2 Membrane protein, integral; Membrane protein, multi-pass; Transporter; Transporter, SLC family Q9BRI3 7780 1p36.11 human K6-ub 34666303 __MEAKEkQHLLDAR protein degradation; ubiquitination 25016022 1 0 0 zinc accumulation and secretion -CLTB CLTB Vesicle P09497 1212 5q35.2 human S205-p 25592003 LCDFNPKsSKQCKDV Clathrin_lg_ch endocytosis, induced CHCHD1(INDUCES) 22704991 1 0 0 discriminator for endocytosis of a subset of cargoes -Faah FAAH EC 3.5.1.99; Hydrolase; Membrane protein, integral O08914 14073 4 D1|4 53.08 cM mouse S241-p 34502044 LGTDIGGsIRFPSAF Amidase molecular association, regulation NLRP3(INDUCES) 36104448 1 3 0 -HSPA5 GRP78 Chaperone; Heat shock protein; KINASE P11021 3309 9q33.3 human K123-ac 13362604 PFKVVEKkTKPYIQV HSP70 molecular association, regulation; phosphorylation apoptosis, induced; signaling pathway regulation PERK(DISRUPTS) 20371724 1 1 0 induces phosphorylation of elf2a and activation of eIf2a-ATF4-CHOP pathway -CD44 CD44 Cell adhesion; Membrane protein, integral; Motility/polarity/chemotaxis; Receptor, misc. P16070 960 11p13 human S706-p 450988 LNGEASKsQEMVHLV activity, induced; molecular association, regulation; intracellular localization cell motility, altered; transcription, induced MMP9(DISRUPTS) 1281449; 19582779; 22865879; 9580567 12 58 37 nuclear localization -IRF5 IRF5 DNA-binding; Transcription factor Q13568 3663 7q32.1 human S435-p 26389900 EMFSGELsWSADSIR activity, induced; intracellular localization apoptosis, induced; transcription, induced 18836453; 22412986 3 1 0 -MAP4 MAP4 Cytoskeletal; Motility/polarity/chemotaxis P27816 4134 3p21.31 human K997-ac 6218845 GKVQIVSkKVSYSHI Tubulin-binding cytoskeletal reorganization 28002468 1 1 1 -KLF2 KLF2 C2H2-type zinc finger protein; DNA-binding Q9Y5W3 10365 19p13.11 human K122-sm 31089516 APPGRLVkAEPPEAD transcription, inhibited 23515309 1 1 0 -SIRT1 SIRT1 Apoptosis; DEACETYLASE; Deacetylase; EC 3.5.1.-; Nuclear receptor co-regulator Q96EB6 23411 10q21.3 human Y301-p 25311272 QAMFDIEyFRKDPRP SIR2 molecular association, regulation transcription, inhibited STAT3(INDUCES) 29789426 1 0 1 -HDAC1 HDAC1 DEACETYLASE; Deacetylase; EC 3.5.1.98; Hydrolase; Nuclear receptor co-regulator Q13547 3065 1p35.2-p35.1 human K439-ac 4219801 KNSSNFKkAKRVKTE enzymatic activity, inhibited transcription, inhibited 16762839 1 0 0 -ETV4 ETV4 DNA-binding P43268 2118 17q21.31 human K322-sm 3278908 EKFEGDIkQEGVGAF ETS_PEA3_N transcription, inhibited 17585876 1 0 0 -TBXA2R TXA2-R iso2 GPCR, family 1; Membrane protein, integral; Membrane protein, multi-pass; Receptor, GPCR P21731-2 6915 19p13.3 human T399-p 451396 LLPFEPPtGKALSRK receptor desensitization, altered 15100160 1 0 0 -SRY SRY DNA-binding; Nuclear receptor co-regulator Q05066 6736 Yp11.2 human K136-ac 12674406 YRPRRKAkMLPKNCS molecular association, regulation; intracellular localization cell differentiation, induced KPNB1(INDUCES) 15297880 1 0 0 -Slamf1 SLAM Membrane protein, integral; Receptor, misc. Q9QUM4 27218 1 H3|1 79.54 cM mouse Y315-p 448264 QDPCTTIyVAATEPA molecular association, regulation Fyn(INDUCES) 11477403 2 0 0 -RXRA RXRA DNA-binding; Motility/polarity/chemotaxis; Nuclear receptor P19793 6256 9q34.2 human T82-p 453096 HSMSVPTtPTLGFST Nuc_recep-AF1 molecular association, regulation carcinogenesis, induced; cell growth, induced; apoptosis, inhibited; transcription, inhibited SRC-1(DISRUPTS); RARB(DISRUPTS); RXRA(DISRUPTS) 17900311; 20432439 3 0 0 -BRD4 BRD4 KINASE; Kinase, protein; Protein kinase, Ser/Thr (non-receptor); Protein kinase, atypical O60885 23476 19p13.12 human T204-p 87391000 PNTTQAStPPQTQTP protein stabilization; molecular association, regulation; protein conformation transcription, induced CDK9(INDUCES); PIN1(INDUCES) 28481868 1 0 0 -NHERF1 NHERF Adaptor/scaffold; Motility/polarity/chemotaxis O14745 9368 17q25.1 human T156-p 3864004 ELRPRLCtMKKGPSG PDZ molecular association, regulation; intracellular localization cell growth, induced SKP2(INDUCES) 25492869; 26862730 2 0 2 promotes cell proliferation; increased nuclear localization -CDC25A CDC25A EC 3.1.3.48; Motility/polarity/chemotaxis; PHOSPHATASE; Protein phosphatase, dual-specificity P30304 993 3p21.31 human K169-ub 41483908 SHGLQEGkDLFTQRQ M-inducer_phosp intracellular localization 36539837 1 3 0 -Map3k4 MEKK4 EC 2.7.11.25; KINASE; Kinase, protein; Protein kinase, STE; Protein kinase, Ser/Thr (non-receptor) O08648 26407 17 8.42 cM|17 A1 mouse S492-p 468186 RKLERLEsEEDSIGW MEKK4_N molecular association, regulation; enzymatic activity, induced GADD45A(INDUCES) 27358404 1 21 18 -MAP3K11 MLK3 EC 2.7.11.25; KINASE; Kinase, protein; Protein kinase, Ser/Thr (non-receptor); Protein kinase, TKL Q16584 4296 11q13.1 human S789-p 487506 VSAGPRPsPLPSPQP enzymatic activity, induced apoptosis, induced 17711861 1 15 6 induces activation of itself and JNK -MEF2C MEF2C iso3 DNA-binding; Transcription factor Q06413-3 4208 5q14.3 human S387-p 1729600 TRHEAGRsPVDSLSS activity, induced transcription, altered 9069290; 9384584 3 2 0 -APP APP iso4 Apoptosis; Cell surface; Membrane protein, integral; Receptor, misc.; Transcription factor P05067-4 351 21q21.3 human S655-p 448200 LKKKQYTsIHHGVVE APP_amyloid protein processing exocytosis, altered 19381782 6 1 0 -Cacng2 Stargazin Channel, calcium; Membrane protein, integral; Membrane protein, multi-pass Q71RJ2 84347 7q34 rat T321-p 451273 NTANRRTtPV_____ molecular association, regulation PSD-95(INDUCES); PSD-95(DISRUPTS) 12122038; 19968761 3 0 0 -NEDD8 NEDD8 Ubiquitin-like modifier Q15843 4738 14q12 human K11-ac 33364162 KVKTLTGkEIEIDIE ubiquitin molecular association, regulation PARP1(INDUCES) 30804002 1 3 0 -FOXM1 FOXM1 iso2 DNA-binding; Transcription factor Q08050-2 2305 12p13.33 human K480-sm 31898507 PSPAPSFkEESSHSW protein degradation transcription, inhibited 25533473 2 0 0 -PLCG1 PLCG1 Carbohydrate Metabolism - inositol phosphate; EC 3.1.4.11; Motility/polarity/chemotaxis; Phospholipase P19174 5335 20q12 human Y783-p 447667 EGRNPGFyVEANPMP activity, induced; molecular association, regulation; intracellular localization; protein conformation; phosphorylation; enzymatic activity, induced carcinogenesis, inhibited; cell motility, induced; cell motility, altered; transcription, induced; cytoskeletal reorganization; signaling pathway regulation SLP76(INDUCES); GRB2(INDUCES); GADS(INDUCES); VEGFR2(INDUCES) 12029091; 16038803; 16525023; 17372230; 21760611; 22847294; 30131370; 30873169; 31196981; 33931484; 35124007; 35367415 92 42 558 -NR1H4 NR1H4 DNA-binding; Nuclear receptor Q96RI1 9971 12q23.1 human K167-ac 12159007 FFRRSITkNAVYKCK zf-C4 protein stabilization; molecular association, regulation transcription, inhibited RXRA(DISRUPTS) DNA(DISRUPTS) 19883617 1 1 0 -SCFD1 SCFD1 Vesicle Q8WVM8 23256 14q12 human K515-ac 1881937803 SYGSTTTkPMGLLSR autophagy, inhibited 35465820 1 1 0 SCFD1 deacetylation promotes SNARE complex formation -Id2 ID2 DNA-binding; Transcription, coactivator/corepressor P41136 15902 12 A1.3|12 8.57 cM mouse S14-p 4706868 VRSVRKNsLSDHSLG neural plasticity; cell growth, induced; transcription, altered 34599103 3 16 0 -OSMR OSMR Membrane protein, integral; Receptor, cytokine Q99650 9180 5p13.1 human Y917-p 1930200 AGETSLNyVSQLASP phosphorylation 18430728 2 0 0 important for STAT3 activation -HDAC1 HDAC1 DEACETYLASE; Deacetylase; EC 3.5.1.98; Hydrolase; Nuclear receptor co-regulator Q13547 3065 1p35.2-p35.1 human Y72-p 55375010 TKYHSDDyIKFLRSI Hist_deacetyl protein stabilization; intracellular localization apoptosis, inhibited 33976119 1 2 0 inhibits ubiquitination -RPS6KA3 RSK2 EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, AGC; Protein kinase, Ser/Thr (non-receptor) P51812 6197 Xp22.12 human S386-p 448065 HQLFRGFsFVAITSD Pkinase_C enzymatic activity, induced 37059179 14 19 59 -SEPTIN7 SEPT7 Cell cycle regulation; Cytoskeletal; Hydrolase Q16181 989 7p14.2 human T426-p 476328 EQQNSSRtLEKNKKK molecular association, regulation; intracellular localization 14-3-3 gamma(INDUCES) 35602601 2 56 46 -Btk Btk EC 2.7.10.2; KINASE; Kinase, protein; Protein kinase, TK; Protein kinase, tyrosine (non-receptor) P35991 12229 X E3|X 56.18 cM mouse S180-p 447577 GSLKPGSsHRKTKKP intracellular localization; activity, inhibited 11598012 2 4 0 -DUOX1 DUOX1 EC 1.6.3.1; Membrane protein, integral; Membrane protein, multi-pass; Oxidoreductase Q9NRD9 53905 15q21.1 human S1217-p 6370300 SHHFRRRsFRGFWLT Ferric_reduct enzymatic activity, inhibited 19144650 1 1 0 -KAT2B PCAF ACETYLTRANSFERASE; Acetyltransferase; EC 2.3.1.48; Nuclear receptor co-regulator Q92831 8850 3p24.3 human S264-p 1870426001 YWHLEAPsQRRLRSP PCAF_N molecular association, regulation; acetylation DNA(DISRUPTS) 32966758 1 0 0 inhibits histone acetylation thus stabilizing replication forks/ prevent excessive fork degradation -Relb RELB Transcription factor Q04863 19698 7 A3|7 9.93 cM mouse K273-ub 3055604 LSEPVYDkKSTNTSE RHD_DNA_bind transcription, induced 18620544 1 0 0 -PI4K2A PI4K2A EC 2.7.1.67; Kinase, lipid; Motility/polarity/chemotaxis Q9BTU6 55361 10q24.2 human S5-p 2022753 ___MDETsPLVSPER endocytosis, inhibited 37314927 2 12 0 -ID2 ID2 DNA-binding; Transcription, coactivator/corepressor Q02363 3398 2p25.1 human S5-p 451265 ___MKAFsPVRSVRK molecular association, regulation; protein stabilization; ubiquitination cell cycle regulation; cell growth, inhibited; transcription, altered APC(DISRUPTS) 26756672; 35440621 4 6 0 inhibits ubiquitination -BUB1B BUB1B EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, Other; Protein kinase, Ser/Thr (non-receptor); Tumor suppressor O60566 701 15q15.1 human K250-ac 7761217 IRVGGALkAPSQNRG protein stabilization; ubiquitination cell cycle regulation; carcinogenesis, inhibited 19407811; 22340495 5 1 0 -PHF2 PHF2 DEMETHYLASE; Demethylase; EC 1.14.11.-; Nucleolus O75151 5253 9q22.31 human S757-p 20936500 NARVKKEsGSSAAGI molecular association, regulation transcription, induced Mrf-2(INDUCES) DNA(INDUCES) 21532585 1 0 1 demethylation of Mrf-2 K336, complex is then targeted to promoters and removes repressive H3K9m2 -NF2 Merlin Cytoskeletal; Motility/polarity/chemotaxis; Tumor suppressor P35240 4771 22q12.2 human K387-ub 21178796 TADLLAEkAQITEEE ERM_helical molecular association, regulation; intracellular localization LATS1(DISRUPTS) 30918126 1 3 0 K63 kinked -NOS3 eNOS Amino Acid Metabolism - arginine and proline; EC 1.14.13.39; Oxidoreductase P29474 4846 7q36.1 human S1179-p 467802 RIRTQSFsLQERQLR enzymatic activity, induced apoptosis, inhibited 10973320; 33539947; 34499618 11 8 1 -Cpeb1 CPEB RNA-binding; Translation P70166 12877 7|7 D3 mouse S177-p 483983 DTRPILDsRSSSPSD CEBP1_N neural plasticity; cytoskeletal reorganization; translation, induced 17567800 3 2 0 spine density and shape, long-term depression and motor coordination -Tp53 p53 Activator; DNA-binding; Motility/polarity/chemotaxis; Nuclear receptor co-regulator; Transcription factor; Tumor suppressor P02340 22059 11 B3|11 42.83 cM mouse S373-p 447570 LKTKKGQsTSRHKKT acetylation 15794754 13 0 0 substitution of either alanine or aspartic acid at this site abrogated p53 acetylation at K379 (K382 in human) -Lepr LEPR Membrane protein, integral; Receptor, cytokine P48356 16847 4 C6|4 46.96 cM mouse Y1138-p 448434 SGENFVPyMPQFQTC activity, induced; molecular association, regulation; phosphorylation transcription, induced; signaling pathway regulation; transcription, altered SHP-2(INDUCES); STAT3(INDUCES) 10449753; 10799542; 11018044; 15634336; 18718905; 22768838; 24302741 16 0 0 mutation of this site (Y3F) inhibits JAK2/STAT3 pathway, which modulates energy homeostasis ; induces STAT3 phosphorylation and LEPR-STAT3 signaling -OSBP OSBP Lipid-binding P16258 rabbit Y396-p 2089800 DISLDEQyKHQLEET activity, induced 18230613 1 1 0 Y396F mutant inhibits oxysterol-mediated phosphorylation and activation of Stat3 -SIAH2 SIAH2 EC 6.3.2.-; EC 6.3.2.19; Ligase; Transcription, coactivator/corepressor; UBIQUITIN LIGASE; Ubiquitin conjugating system; Ubiquitin ligase O43255 6478 3q25.1 human S167-p 22878300 ICEYRPYsCPCPGAS Sina enzymatic activity, induced 21409570 1 0 0 -DNM1L DRP1 Apoptosis; EC 3.6.5.5; Endoplasmic reticulum; Hydrolase; Microtubule-binding; Mitochondrial; Motor O00429 10059 12p11.21 human S616-p 454690 PIPIMPAsPQKGHAV activity, induced; molecular association, regulation; acetylation; enzymatic activity, inhibited; intracellular localization; protein conformation; phosphorylation cell differentiation, inhibited; carcinogenesis, induced; carcinogenesis, inhibited; cell motility, induced; cell growth, inhibited; apoptosis, induced; transcription, induced; transcription, altered; signaling pathway regulation; autophagy, induced; exocytosis, induced; cell growth, induced; apoptosis, inhibited; cytoskeletal reorganization MFF(INDUCES); DRP1(INDUCES); Rab7(INDUCES) 21119009; 21646527; 25012575; 25658205; 28314909; 31308800; 31744518; 31949126; 31992853; 32433544; 33126710; 33476635; 33850055; 33850876; 33940381; 33941653; 34475379; 34534628; 34963686; 35100966; 35122996; 35332310; 35544764; 35686673; 35697120; 35739087; 36584588; 36759571; 36922509; 37232206; 37442283 132 78 114 -TAL1 TAL1 DNA-binding; Oncoprotein; Transcription factor P17542 6886 1p33 human S122-p 450663 DGRMVQLsPPALAAP protein degradation 11904294 2 10 85 -RCC1 RCC1 Cell cycle regulation; GEF; GEF, Ras P18754 1104 1p35.3 human S11-p 452007 KRIAKRRsPPADAIP molecular association, regulation; intracellular localization cell cycle regulation; cytoskeletal reorganization; cell growth, altered KPNA4(DISRUPTS) 15203004; 17855385; 18568422; 34356619 4 61 9 -PBK PBK Cancer Testis Antigen (CTA); EC 2.7.12.2; KINASE; Kinase, protein; Protein kinase, Other; Protein kinase, Ser/Thr (non-receptor); Protein kinase, dual-specificity (non-receptor) Q96KB5 55872 8p21.1 human Y74-p 473837 NPICNDHyRSVYQKR Pkinase protein stabilization; phosphorylation; enzymatic activity, induced cell cycle regulation; carcinogenesis, induced; cell growth, induced; apoptosis, inhibited; signaling pathway regulation 27016416; 31611604; 35546143; 35780928; 36167821 5 5 163 -SIM2 SIM2 DNA-binding; Motility/polarity/chemotaxis Q14190 6493 21q22.13 human S115-p 1385533600 ASVHLGLsQVELTGN PAS protein stabilization; molecular association, regulation BRCA1(INDUCES) 30531838 1 0 0 recruitment of RAD51 -Tp73 p73 DNA-binding; Transcription factor; Tumor suppressor Q9JJP2 22062 4 E2|4 83.79 cM mouse T11-p 7437802 TSSSSSStFEHLWSS molecular association, regulation transcription, induced p300(INDUCES) 19218448 1 0 0 -IRF7 IRF7 DNA-binding; Transcription factor Q92985 3665 11p15.5 human S487-p 1276100 LCLSSANsLYDDIEC transcription, inhibited 10893229 2 0 0 -NEK1 NEK1 EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, Other; Protein kinase, Ser/Thr (non-receptor) Q96PY6 4750 4q33 human T141-p 65958203 IFLTKDGtVQLGDFG Pkinase enzymatic activity, induced cell cycle regulation; carcinogenesis, induced; DNA repair, induced; cell growth, induced; apoptosis, induced; transcription, induced 28426283; 30928383 3 0 0 -Mef2d MEF2D DNA-binding; Transcription factor Q63943 17261 3 F1|3 38.78 cM mouse S121-p 2246700 EDKYRRAsEELDGLF HJURP_C protein stabilization; molecular association, regulation; protein conformation; activity, inhibited cell differentiation, altered; transcription, inhibited HDAC9(INDUCES); ASH2L(DISRUPTS); HDAC4(INDUCES) 18299387; 23723416 3 33 9 -H4-16 H4 DNA-binding NP_001139343 530773 cow K12-ac 459013 KGGKGLGkGGAKRHR methylation cell cycle regulation 18698155 93 25 531 complex relationship of acetylation and methylation of CpG dinucleotides on DNA, during development of gametogenesis and embryogenesis -PKM PKM Carbohydrate Metabolism - glycolysis and gluconeogenesis; Carbohydrate Metabolism - pyruvate; EC 2.7.1.40; KINASE; Kinase, other; Mitochondrial; Nucleotide Metabolism - purine P14618 5315 15q23 human S202-p 15721963 TEVENGGsLGSKKGV PK molecular association, regulation; intracellular localization STAT5A(INDUCES) 27340866 1 7 0 nuclear localization -BHLHE41 BHLHB3 Q9C0J9 79365 12p12.1 human K266-sm 31094508 GASRVTIkQEPPGED molecular association, regulation; methylation cell differentiation, inhibited; chromatin organization, altered; transcription, inhibited EHMT2(INDUCES) 23637228 1 0 0 induces histone dimethylation, induces recruitment of EHMT2 to promoters through binding to EHMT2 -Irs1 IRS1 Adaptor/scaffold; Motility/polarity/chemotaxis P35570 25467 9q34 rat Y895-p 447556 EPKSPGEyVNIEFGS molecular association, regulation; phosphorylation signaling pathway regulation GRB2(INDUCES); SHP-2(INDUCES) 33824679; 7504175; 8196603 13 2 0 regulates the insulin pathway; induces MAPK activation/phosphorylation -Dync1li2 DNCLI2 Motility/polarity/chemotaxis Q6PDL0 234663 8 D3|8 53.04 cM mouse T202-p 4739826 PQRRGPLtSGSDEDS DLIC carcinogenesis, induced 33414172 1 3 0 -ABCA1 ABCA1 Membrane protein, integral; Membrane protein, multi-pass; Transporter; Transporter, ABC family; Vesicle O95477 19 9q31.1 human S2054-p 455498 GGNKRKLsTAMALIG ABC_tran activity, induced; ubiquitination 12196520; 26494466 2 0 0 -ANP32B ANP32B Chaperone Q92688 10541 9q22.33 human T244-p 456786 GEKRKREtDDEGEDD intracellular localization transcription, altered 17178712; 19130553 2 49 176 regulates the nucleocytoplasmic translocation of CD83 mRNA and its expression; leads to the translocation of the protein from the nucleus to the cytoplasm; required for efficient CD83 expression -MAPK1 ERK2 EC 2.7.11.24; KINASE; Kinase, protein; Protein kinase, CMGC; Protein kinase, Ser/Thr (non-receptor) P28482 5594 22q11.22 human S248-p 6845000 LGILGSPsQEDLNCI Pkinase molecular association, regulation; intracellular localization; phosphorylation cell growth, induced IPO7(INDUCES); NUP153(DISRUPTS) 18760948; 21730285 2 0 0 -CEBPA C/EBP-alpha DNA-binding; Transcription factor P49715 1050 19q13.11 human R156-m2 1878324501 RVGAPALrPLVIKQE cell cycle regulation; carcinogenesis, induced; cell growth, induced; transcription, inhibited HDAC3(DISRUPTS) 31015230 1 1 0 -H4-16 H4 DNA-binding NP_001139343 530773 cow K8-ac 458959 SGRGKGGkGLGKGGA methylation cell cycle regulation 18698155 85 21 529 complex relationship of acetylation and methylation of CpG dinucleotides on DNA, during development of gametogenesis and embryogenesis -GRK2 GRK2 EC 2.7.11.15; KINASE; Kinase, protein; Protein kinase, AGC; Protein kinase, Ser/Thr (non-receptor) P25098 156 11q13.2 human Y92-p 456873 FYEEIKKyEKLETEE RGS protein degradation; molecular association, regulation G-alpha(q)(INDUCES) 11566877; 16725308 5 0 0 -FBXO31 FBXO31 Cell cycle regulation; UBIQUITIN LIGASE; Ubiquitin conjugating system; Ubiquitin ligase Q5XUX0 79791 16q24.2 human S278-p 13216200 LMKFIYTsQYDNCLT molecular association, regulation; protein stabilization CDH1(DISRUPTS); CDC20(DISRUPTS) 19412162; 29343641 2 0 0 -EIF3A eIF3-theta RNA-binding; Translation; Translation initiation Q14152 8661 10q26.11 human S584-p 471999 ERKERLEsLNIQREK translation, induced 30001349 1 35 17 -Jak2 JAK2 EC 2.7.10.2; KINASE; Kinase, protein; Oncoprotein; Protein kinase, TK; Protein kinase, tyrosine (non-receptor) Q62120 16452 19 C1|19 23.73 cM mouse Y966-p 462255 QICKGMEyLGTKRYI PK_Tyr_Ser-Thr enzymatic activity, induced 20304997 3 3 3 -GNAZ G-alpha(z) Endoplasmic reticulum; G protein, heterotrimeric; G protein, heterotrimeric alpha G((i/o/t/z)); Nuclear envelope P19086 2781 22q11.22-q11.23 human S27-p 451241 DRHLRSEsQRQRREI G-alpha activity, induced; protein conformation 10686433; 9166747 4 0 2 -RET Ret EC 2.7.10.1; KINASE; Kinase, protein; Membrane protein, integral; Oncoprotein; Protein kinase, TK; Protein kinase, tyrosine (receptor) P07949 5979 10q11.21 human K1060-ub 31839905 PSTWIENkLYGMSDP protein degradation; phosphorylation 24425877 1 0 0 Y341 phosphorylation increases Ret ubquitylation -IRF3 IRF3 DNA-binding; Transcription factor Q14653 3661 19q13.33 human K315-ub 56403900 DGEVPKDkEGGVFDL IRF-3 intracellular localization apoptosis, induced 27178468 1 0 0 -Krt8 K8 Cytoskeletal P11679 16691 15 F2|15 57.2 cM mouse S431-p 31880611 GYSGGLSsSYGGLTS carcinogenesis, induced 33847415 1 4 1 -HCFC1 HCFC1 Transcription, coactivator/corepressor P51610 3054 Xq28 human K1807-ub 6423511 PPSKAPMkKENQWFD protein stabilization cell cycle regulation; cell growth, induced 19188440 1 1 0 -Fzd3 FZD3 GPCR, Fz/Smo family; Membrane protein, integral; Membrane protein, multi-pass; Receptor, GPCR Q61086 14365 14 D1|14 34.09 cM mouse T542-p 18507004 SLLRDPNtPIIRKSR receptor internalization, inhibited; phosphorylation endocytosis, inhibited 21316586 1 0 2 enhances PCP signaling, regulating c-Jun phosphorylation, and affecting growth cone guidance -JAK2 JAK2 EC 2.7.10.2; KINASE; Kinase, protein; Oncoprotein; Protein kinase, TK; Protein kinase, tyrosine (non-receptor) O60674 3717 9p24.1 human T174-p 56527200 KVPVTHEtQEECLGM FERM_F2 enzymatic activity, induced transcription, induced 27368100 1 1 0 STAT3 activity induced -Ets1 Ets-1 DNA-binding; Motility/polarity/chemotaxis; Oncoprotein; Transcription factor P27577 23871 9 A4|9 17.97 cM mouse S251-p 449316 GKLGGQDsFESVESY Ets1_N_flank molecular association, regulation; acetylation; intracellular localization transcription, inhibited DNA(DISRUPTS) 30865889 4 13 1 induce acetylation of FOXO1 and suppress gluconeogenesis -SLC25A4 SLC25A4 Membrane protein, integral; Membrane protein, multi-pass; Mitochondrial; Transporter; Transporter, SLC family P12235 291 4q35.1 human K23-ac 25541520 GVAAAVSkTAVAPIE Mito_carr; TM molecular association, regulation 34332952 0 5 0 Acetylation at K23 reduces binding of SLC25A4 to ADP. -BSG BSG Immunoglobulin superfamily; Membrane protein, integral P35613 682 19p13.3 human K350-ub 15385438 FIYEKRRkPEDVLDD carcinogenesis, induced; cell motility, induced; cell growth, induced; transcription, induced 26769849 1 5 3 -CENPJ CENPJ Cell cycle regulation; Microtubule-binding; Transcription, coactivator/corepressor Q9HC77 55835 13q12.12-q12.13 human S1109-p 460560 NPPRRSKsAPPRDLG molecular association, regulation 14-3-3 gamma(INDUCES) 16516142 1 3 0 association with 14-3-3 decreases in mitotic cells -SRC Src EC 2.7.10.2; KINASE; Kinase, protein; Oncoprotein; Protein kinase, TK; Protein kinase, tyrosine (non-receptor) P12931 6714 20q11.23 human S17-p 448231 DASQRRRsLEPAENV enzymatic activity, induced 12221082 10 46 12 Src S16 phosphorylation is necessary and sufficient for Rap1 and Ras activation by isoproterenol. -Rasgrp2 RASGRP2 GEF; GEF, Ras Q9QUG9 19395 19|19 A mouse S554-p 4781198 ECRRRAQsVSLEGSA activity, induced; molecular association, regulation 14-3-3 beta(INDUCES) 26804993 1 5 36 -Src Src EC 2.7.10.2; KINASE; Kinase, protein; Oncoprotein; Protein kinase, TK; Protein kinase, tyrosine (non-receptor) Q9WUD9 83805 3q42 rat Y530-p 448235 FTSTEPQyQPGENL_ molecular association, regulation; enzymatic activity, inhibited cell adhesion, altered PTPRA(INDUCES) 15735685; 36034878 153 24 968 -Brsk2 BRSK2 EC 2.7.11.1; EC 2.7.11.26; KINASE; Kinase, protein; Protein kinase, CAMK; Protein kinase, Ser/Thr (non-receptor) Q69Z98 75770 7|7 F5 mouse S490-p 2085948 IKNSFLGsPRFHRRK protein stabilization; enzymatic activity, inhibited; phosphorylation 23790753 1 30 3 inhibits axon branching (activated in BRSK2 18A mutant) -GOLPH3 GOLPH3 Mitochondrial Q9H4A6 64083 5p13.3 human T143-p 31834909 ALKHVKEtQPPETVQ GPP34 activity, induced; molecular association, regulation DNA repair, induced; signaling pathway regulation MYO18A(INDUCES) 24485452 1 1 0 DNA-PK/GOLPH3/MYO18A pathway, Increased phosphorylation leads to DNA-damage-induced Golgi dispersion -AURKA AurA EC 2.7.11.1; KINASE; Kinase, protein; Oncoprotein; Protein kinase, Other; Protein kinase, Ser/Thr (non-receptor) O14965 6790 20q13.2 human K125-ac 1873284340 QKNEESKkRQWALED enzymatic activity, induced cell cycle regulation; carcinogenesis, induced; cell motility, induced; cell growth, induced 28915666 1 0 0 may lead to development of cancer -GYS1 GYS1 Carbohydrate Metabolism - starch and sucrose; EC 2.4.1.11; Transferase P13834 100008660 rabbit S649-p 448239 VPPSPSLsRHSSPHQ Glycogen_syn enzymatic activity, inhibited 10909964; 6402364 14 15 1 activated by insulin treatment -Lyn LYN EC 2.7.10.2; KINASE; Kinase, protein; Oncoprotein; Protein kinase, TK; Protein kinase, tyrosine (non-receptor) P25911 17096 4 A1|4 2.05 cM mouse Y397-p 448695 RVIEDNEyTAREGAK PK_Tyr_Ser-Thr enzymatic activity, induced carcinogenesis, induced; cell motility, induced; cell growth, induced Bcr(NOT_REPORTED) 10415030; 21636860; 35150959 34 61 2054 -GAPDH GAPDH Carbohydrate Metabolism - glycolysis and gluconeogenesis; EC 1.2.1.12; Oxidoreductase P04406 2597 12p13.31 human S98-p 52434703 GAEYVVEsTGVFTTM Gp_dh_N enzymatic activity, induced 26629320 1 1 0 -Nos1 nNOS Amino Acid Metabolism - arginine and proline; EC 1.14.13.39; Oxidoreductase P29476 24598 12q16 rat K856-ac 2459109 SSYSDSRkSSGDGPD Flavodoxin_1 activity, induced 18415985 1 1 0 -IQGAP2 IQGAP2 G protein regulator, misc.; Motility/polarity/chemotaxis Q13576 10788 5q13.3 human T716-p 18964300 EYMHRRQtFIDNTDS molecular association, regulation; intracellular localization cytoskeletal reorganization RAC1(INDUCES); AKAP11(INDUCES) 21460214; 21776420 2 2 0 recruitment of active Rac to the complex, membrane ruffling; membrane ruffles -CEP192 CEP192 Cell cycle regulation; Microtubule-binding Q8TEP8 55125 18p11.21 human T44-p 41159607 GLPVAVStLARDRSS molecular association, regulation cell cycle regulation; cytoskeletal reorganization PLK1(INDUCES) 26012549 1 0 0 required for proper spindle formation and mitotic progression -CALCOCO2 CALCOCO2 Calcium-binding Q13137 10241 17q21.32 human T39-p 1336919200 YIPGGDVtCHYTFTQ SKICH autophagy, altered 30459273 1 0 0 -VRK1 VRK1 EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, CK1; Protein kinase, Ser/Thr (non-receptor) Q99986 7443 14q32.2 human S342-p 5938010 DDGKLDLsVVENGGL cytoskeletal reorganization 19103756 2 5 0 necessary for Golgi fragmentation -HK1 HK1 Carbohydrate Metabolism - amino sugar and nucleotide sugar; Carbohydrate Metabolism - fructose and mannose; Carbohydrate Metabolism - galactose; Carbohydrate Metabolism - glycolysis and gluconeogenesis; Carbohydrate Metabolism - starch and sucrose; EC 2.7.1.1; Kinase, other; Mitochondrial P19367 3098 10q22.1 human S364-p 55569801 TRLGVEPsDDDCVSV Hexokinase_2 enzymatic activity, induced 27153534 1 1 0 -Ntrk2 TrkB EC 2.7.10.1; KINASE; Kinase, protein; Membrane protein, integral; Protein kinase, TK; Protein kinase, tyrosine (receptor) Q63604 25054 17p14 rat S478-p 478364 SNDDDSAsPLHHISN cytoskeletal reorganization 17341134 2 1 0 dendritic growth -RIPK1 RIPK1 EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, Ser/Thr (non-receptor); Protein kinase, TKL Q13546 8737 6p25.2 human K530-ac 27992509 PPTDESIkYTIYNST RHIM molecular association, regulation RIPK3(DISRUPTS) 23201684 1 1 0 -Trarg1 TUSC5 Membrane protein, integral; Membrane protein, multi-pass Q8C838 237858 11|11 B5 mouse S76-p 7829266 PSLSGSPsRVSSRRA intracellular localization 35594055 1 3 1 regulates GLUT4 translocation -Map1b MAP1B Cytoskeletal; Motility/polarity/chemotaxis P14873 17755 13 D1|13 52.9 cM mouse S1260-p 454136 SLSPSPPsPIEKTPL cytoskeletal reorganization 15731007 3 71 17 induces a loss of stable microtubules -Tnp2 TP2 DNA-binding P11101 24840 10q11 rat K91-ac 3613758 TLEGKVSkRKAVRRR TP2 molecular association, regulation chromatin organization, altered NPM3(DISRUPTS) 19710011 2 2 1 -Myod1 MyoD DNA-binding; RNA splicing; Transcription factor P10085 17927 7 B3|7 30.03 cM mouse K133-ub 7761226 NEAFETLkRCTSSNP HLH protein degradation 19319192 1 0 0 regulation of skeletal muscle myotube atrophy -Syt1 SYT1 Calcium-binding; Membrane protein, integral; Vesicle P21707 25716 7q21 rat T195-p 1878260800 DKKKKFEtKVHRKTL molecular association, regulation exocytosis, inhibited SNAP-25(DISRUPTS) 35914553 1 0 0 -Atad3 ATAD3A Mitochondrial Q925I1 108888 4|4 E2 mouse K134-ac 11322823 ARAQYQDkLARQRYE ATAD3_N molecular association, regulation; activity, inhibited ATAD3A(DISRUPTS) 30914652 1 3 1 dimerization of ATAD3A is promoted by deacetylation of ATAD3A and Drp1-mediated mitochondrial fragmentation -PLAGL2 PLAGL2 C2H2-type zinc finger protein; DNA-binding Q9UPG8 5326 20q11.21 human K269-sm 483050 CSSTVSVkEELSPVL intracellular localization cell growth, induced; transcription, inhibited 16207715 3 0 0 -PHF2 PHF2 DEMETHYLASE; Demethylase; EC 1.14.11.-; Nucleolus O75151 5253 9q22.31 human S655-p 3175945 KALRPPTsPGVFGAL carcinogenesis, inhibited; cell motility, inhibited 36872368 2 14 1 AMPKA2 induced PHF2-S655 phosphorylation suppresses cell migration, invasion, and metastasis. -DAPK3 DAPK3 EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, CAMK; Protein kinase, Ser/Thr (non-receptor); Tumor suppressor O43293 1613 19p13.3 human T225-p 454891 LGETKQEtLTNISAV Pkinase enzymatic activity, induced 15611134 2 0 0 -SNAI2 Snail2 Apoptosis; C2H2-type zinc finger protein; Motility/polarity/chemotaxis; Transcription factor O43623 6591 8q11.21 human S251-p 63243400 KNCSKTFsRMSLLHK zf-C2H2 intracellular localization transcription, induced 28288135 1 0 0 nuclear localization -Marcks MARCKS Actin-binding; Motility/polarity/chemotaxis P26645 17118 10 B1|10 19.49 cM mouse S156-p 447787 KRFSFKKsFKLSGFS MARCKS receptor internalization, induced; intracellular localization carcinogenesis, induced; cell motility, altered 20211725; 34556581 24 30 7 -Taok1 TAO1 EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, STE; Protein kinase, Ser/Thr (non-receptor) Q5F2E8 216965 11|11 B5 mouse T440-p 23150854 RNREHFAtIRTASLV molecular association, regulation cytoskeletal reorganization MYL5(INDUCES); DBN1(INDUCES) 25456499 2 2 1 spine development -Aurkb AurB EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, Other; Protein kinase, Ser/Thr (non-receptor) O70126 20877 11 B3|11 42.32 cM mouse K103-ub 40212804 VYLAREKkSRFIVAL Pkinase protein degradation cell cycle regulation; carcinogenesis, inhibited; apoptosis, induced 23928698 1 1 0 -DNMT3A DNMT3A Amino Acid Metabolism - cysteine and methionine; EC 2.1.1.37; METHYLTRANSFERASE; Methyltransferase; Methyltransferase, DNA Q9Y6K1 1788 2p23.3 human R882-me 1877292601 TDVSNMSrLARQRLL molecular association, regulation; methylation; enzymatic activity, induced cell differentiation, induced; transcription, altered DNMT3A(DISRUPTS) DNA(DISRUPTS) 31076446; 31582562 5 0 0 DNA binding using fluorescence polarization, R882H mutation causes a reduction in DNA methyltransferase activity, and stabilizes the formation of large oligomers reducing activity, ; R882 mutants R882 showed DNA methylation of CpGs were significantly lower at HLF transcription start sites as compared to controls. -CASP2 CASP2 Apoptosis; EC 3.4.22.55; Protease P42575 835 7q34 human S340-p 10892800 DGKNHAGsPGCEESD Peptidase_C14 apoptosis, altered 19730412 1 12 0 -ZMYM2 ZNF198 Transcription factor Q9UBW7 7750 13q12.11 human S309-p 17434113 DSLSPVAsLPKQIFQ molecular association, regulation; ubiquitination HDAC1(DISRUPTS); LSD1(DISRUPTS) 25855382 1 3 0 -PKP1 plakophilin 1 Cell adhesion; Motility/polarity/chemotaxis Q13835 5317 1q32.1 human S188-p 15413421 QNRYSFYsTCSGQKA activity, induced; protein stabilization cell motility, induced; cell growth, induced; translation, induced; cell adhesion, inhibited 23444369 1 2 7 -SNAI1 Snail1 C2H2-type zinc finger protein; Transcription factor O95863 6615 20q13.13 human S96-p 455883 TSLSDEDsGKGSQPP protein degradation; ubiquitination; intracellular localization cell motility, altered; transcription, altered FBW1B(INDUCES) 15448698; 15647282; 19004823 4 1 0 Localization mediated by S107, S111, S115 and S119. -Scn2a SCN2A Channel, sodium; Membrane protein, integral; Membrane protein, multi-pass P04775 24766 3q21 rat Y1498-p 1046200 TEEQKKYyNAMKKLG activity, inhibited 17959797 1 0 0 -DAXX DAXX Apoptosis; Nuclear receptor co-regulator; Nucleolus; Transcription, coactivator/corepressor Q9UER7 1616 6p21.32 human S184-p 10438000 QSPRTRGsRRQIQRL protein stabilization; ubiquitination apoptosis, induced 19789334; 19789335 2 0 0 required for TNF alpha -dependent accumulation of Daxx in cells ; phosphorylation induces K63-linked polyubiquitination of DAXX at K122 -EP300 p300 ACETYLTRANSFERASE; Acetyltransferase; EC 2.3.1.48; Motility/polarity/chemotaxis; Nuclear receptor co-regulator; Transcription, coactivator/corepressor Q09472 2033 22q13.2 human S106-p 14652802 GPGQVMAsQAQQSSP molecular association, regulation; acetylation; protein stabilization; enzymatic activity, induced NBS1(INDUCES) 20471956; 21108945 3 0 0 required for NBS1 stability; regulates stability of NBS1 and its recruitment into damaged DNA -TERT TERT iso3 DNA-binding; EC 2.7.7.49; Nucleolus; Transferase O14746-3 7015 5p15.33 human K329-ub 14561003 PPVYAETkHFLYSSG protein degradation chromatin organization, altered; apoptosis, induced 20453884 1 0 0 -RUNX1 AML1 iso8 DNA-binding; Oncoprotein; Transcription factor Q01196-8 861 21q22.12 human R233-me 2363103 SELEQLRrTAMRVSP apoptosis, induced; transcription, induced 32573733 2 1 0 -Cacna1b CACNA1B Channel, calcium; Membrane protein, integral; Membrane protein, multi-pass Q02294 257648 3p13 rat S898-p 455281 ARPRRSHsKEAPGAD activity, inhibited 11312277 2 2 0 Phosphorylation by PKC prevents effects of syntaxin 1A on voltage dependent inactivation of N-type calcium channels. -PRKDC DNAPK DNA repair, damage; EC 2.7.11.1; KINASE; Kinase, protein; Nucleolus; Protein kinase, Ser/Thr (non-receptor); Protein kinase, atypical P78527 5591 8q11.21 human S3205-p 452351 TPLPEDNsMNVDQDG FAT intracellular localization cell cycle regulation; DNA repair, induced 24844881; 32674014 4 29 4 -IGF1R IGF1R EC 2.7.10.1; KINASE; Kinase, protein; Membrane protein, integral; Protein kinase, TK; Protein kinase, tyrosine (receptor) P08069 3480 15q26.3 human Y1280-p 450101 GFREVSFyYSEENKL cell differentiation, altered; cell growth, altered 10786694 5 0 0 observed in quadruple mutant Y980/1280/1281/1346F -NBN NBS1 Cell cycle regulation; DNA repair, damage O60934 4683 8q21.3 human S278-p 449968 VDTGITNsQTLIPDC NIBRIN_BRCT_II phosphorylation cell cycle regulation; apoptosis, induced; chromatin organization, altered 12861053; 14707289; 18003706; 18644472 10 0 0 phosphorylation of RFA2; important for apoptosis induction; S phase checkpoint; telomere maintenance -RXRA RXRA DNA-binding; Motility/polarity/chemotaxis; Nuclear receptor P19793 6256 9q34.2 human S66-p 333674900 NGMGPPFsVISSPMG Nuc_recep-AF1 ubiquitination 29137318 1 0 0 negatively regulated beta-catenin expression by ubiquitination of ?-catenin in CRC -Prkcz PKCZ EC 2.7.11.13; KINASE; Kinase, protein; Protein kinase, AGC; Protein kinase, Ser/Thr (non-receptor) P09217 25522 5q36 rat T410-p 447510 GPGDTTStFCGTPNY Pkinase protein degradation; intracellular localization; enzymatic activity, induced cytoskeletal reorganization; transcription, altered TNNI1(INDUCES); desmin(INDUCES); TPM1(INDUCES); MYO1C(INDUCES); TNNT1(INDUCES) 11141077; 11222751; 14580237; 17724026 45 3 10 -Gata1 GATA1 DNA-binding; Transcription factor P17679 14460 X A1.1|X 3.59 cM mouse K245-ac 466357 NRPLIRPkKRMIVSK protein degradation; acetylation; ubiquitination; phosphorylation DNA(INDUCES) 16858405 3 1 0 Phosphorylation and acetylation cause the degradation of acetylated GATA-1; acetylation of GATA-1 causes ubiquitination; DNA binding is required for MAPK-dependent phosphorylation -NDRG1 NDRG1 Cell development/differentiation; Vesicle Q92597 10397 8q24.22 human K14-sm 40320202 DVDLAEVkPLVEKGE protein degradation; ubiquitination 25712528 1 1 0 promotes downregulation of p21 expression -FLJ33534 FLJ33534 Unknown function Q8N2B8 285150 2p25.1 human K124-ub 52485011 QILGSTLkLFRHPPS protein degradation 26676607 0 1 0 -GABBR1 GABBR1 GPCR, family 3; Membrane protein, integral; Membrane protein, multi-pass; Receptor, GPCR Q9UBS5 2550 6p22.1 human Y230-p 3436001 GQATKYLyELLYNDP ANF_receptor molecular association, regulation; phosphorylation carcinogenesis, induced; cell growth, induced; signaling pathway regulation PTP-PEST(INDUCES) 34778730 1 0 1 binding to PTP-PEST inhibits PTP-PEST binding to EGFR, induces EGFR phosphorylation, thus regulating AKT signaling -APP APP Apoptosis; Cell surface; Membrane protein, integral; Receptor, misc.; Transcription factor P05067 351 21q21.3 human K751-ne 12124800 PEERHLSkMQQNGYE APP_amyloid transcription, inhibited Fe65(DISRUPTS) 18096514 1 0 0 -STAT3 STAT3 DNA-binding; Motility/polarity/chemotaxis; Nuclear receptor co-regulator; Transcription factor P40763 6774 17q21.2 human K49-ac 461010 DWAYAASkESHATLV STAT_int activity, induced; molecular association, regulation; intracellular localization transcription, induced p300(INDUCES) 16285960; 18782771 3 1 0 affects nuclear-cytoplasmic redistribution of the protein; induces enhanceosome formation -CDH5 CDH5 Cell adhesion; Membrane protein, integral; Motility/polarity/chemotaxis P33151 1003 16q21 human S665-p 2562900 YDVSVLNsVRRGGAK intracellular localization 18194650 3 0 0 -CALR Calreticulin ACETYLTRANSFERASE; Acetyltransferase; Calcium-binding; Motility/polarity/chemotaxis; Nuclear receptor co-regulator; Secreted; Secreted, signal peptide P27797 811 19p13.13 human K153-ac 4219808 VIFNYKGkNVLINKD Calreticulin protein conformation 18795239 1 1 0 -IFIH1 MDA5 Apoptosis; EC 3.6.4.13; Helicase Q9BYX4 64135 2q24.2 human K865-sm 63243405 IHCVQNMkPEEYAHK phosphorylation 28250012 1 0 0 dephosphorylation -RPTOR Raptor Adaptor/scaffold Q8N122 57521 17q25.3 human T706-p 11315002 TTEGGSLtPVRDSPC intracellular localization; enzymatic activity, induced cell cycle regulation 21900751; 22493283 8 9 0 -DIPK1C DIPK1C Membrane protein, integral Q0P6D2 125704 18q22.3 human S51-p 1877626502 RAHPGVLsERCTDEK PIP49_N neural plasticity; apoptosis, inhibited 35858575 1 1 0 -SRPK1 SRPK1 EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, CMGC; Protein kinase, Ser/Thr (non-receptor) Q96SB4 6732 6p21.31 human T326-p 25724401 ENPPNKMtQEKLEES intracellular localization RNA splicing, induced 22727668; 33808326 2 1 0 translocation to the nucleus-regulation of E1A splicing -TTK TTK Cancer Testis Antigen (CTA); EC 2.7.12.1; KINASE; Kinase, protein; Protein kinase, Other; Protein kinase, dual-specificity (non-receptor) P33981 7272 6q14.1 human T675-p 487539 ANQMQPDtTSVVKDS Pkinase activity, induced; enzymatic activity, inhibited cell cycle regulation; chromatin organization, altered 18680479; 31511308 5 2 0 microtubule?kinetochore attachment; in vitro -BACH2 BACH2 DNA-binding; Transcription factor Q9BYV9 60468 6q15 human K276-sm 2798317 GLARGQIkSEPPSEE intracellular localization 18201693 2 0 0 mobility of nuclear domains -TRIM32 TRIM32 EC 6.3.2.-; EC 6.3.2.19; Ligase; UBIQUITIN LIGASE; Ubiquitin conjugating system; Ubiquitin ligase Q13049 22954 9q33.1 human S339-p 3195098 VVASPRAsPAKQRGP intracellular localization cell growth, inhibited 25100564 2 19 0 promotes Asymmetric Cell Division -OTULIN FAM105B EC 3.4.19.12 Q96BN8 90268 5p15.2 human K66-ub 12317109 ADEIEKEkELLIHER protein conformation FAM105B(INDUCES) 35939695 1 6 8 genotoxic stress induces FAM105B dimerization, FAM105B self-deubiquitination, NF-kB Activation -Rps6kb1 p70S6K iso2 EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, AGC; Protein kinase, Ser/Thr (non-receptor); Translation P67999-2 83840 10q26 rat S424-p 448357 GSPRTPVsPVKFSPG activity, induced cell growth, altered 16195541 102 54 247 PI3K, Akt and mTOR activation are required for 5-HT-induced proliferatioin. Wortmanin LY294002 and NL-71-101 dose-dependently inhibited 5HT induced proliferation. -CEBPD C/EBP-delta DNA-binding; Motility/polarity/chemotaxis P49716 1052 8q11.21 human K120-sm 3496602 PAAPRLLkREPDWGD molecular association, regulation transcription, inhibited p300(DISRUPTS) 16397300 2 0 0 -DLGAP1 SAPAP1 iso2 Cytoskeletal O14490-2 9229 18p11.31 human S191-p 480585 CFRMRSHsYVRAIEK molecular association, regulation PSD-95(DISRUPTS) 23143515 2 2 4 -Snap23 SNAP23 Vesicle O70377 64630 3q35 rat S120-p 455263 NVVSKQPsRITNGQP SNAP-25 molecular association, regulation; intracellular localization exocytosis, inhibited; exocytosis, altered STX17(INDUCES) 20967886; 29485121; 33213278 9 2 0 mediates the movem ent of SNAP-23 to internal locations and then its association with lysosomal membranes, SNAP-23 membrane association dynamics and subsequently MC degranulation -MAPRE1 EB1 Cytoskeletal; Motility/polarity/chemotaxis Q15691 22919 20q11.21 human T154-p 31883043 NKPKKPLtSSSAAPQ molecular association, regulation; protein conformation cytoskeletal reorganization Restin(INDUCES); dynactin 1(INDUCES); TUBB(INDUCES) 27721984; 28039481 2 2 0 astral microtubule stability ; regulating astral microtubule stability and spindle orientation/positioning -RGS18 RGS18 GAP; GAP, RGS Q9NS28 64407 1q31.2 human S49-p 451167 KEKRNRLsLLVQKPE molecular association, regulation signaling pathway regulation 14-3-3 gamma(INDUCES) 22234696; 24244663 3 5 0 Ca 2+ signaling -TET1 TET1 DNA-binding; EC 1.14.11.n2; Oxidoreductase Q8NFU7 80312 10q21.3 human S1971-p 1881549502 SEADEPPsDEPLSDD protein stabilization carcinogenesis, induced; cell growth, induced; apoptosis, inhibited; transcription, induced 36989375 1 0 0 -ABCA4 ABCA4 Membrane protein, integral; Membrane protein, multi-pass; Transporter; Transporter, ABC family P78363 24 1p22.1 human T901-p 20940701 LEKTEPLtEETEDPE protein stabilization; protein conformation 21721517 1 1 0 -SPAG5 SPAG5 Cell cycle regulation Q96R06 10615 17q11.2 human K409-ub 53415401 QTGLVGTkHSTSETE protein degradation; intracellular localization cell cycle regulation; cytoskeletal reorganization 26748699 1 3 0 regulation of cell division and cytokinesis -FANCI FANCI Cell cycle regulation; DNA repair, damage Q9NVI1 55215 15q26.1 human S559-p 11952935 SLSSSQCsQSLSVSQ FANCI_HD2 molecular association, regulation; ubiquitination DNA repair, induced; cell growth, inhibited FANCD2(INDUCES); MCM5(DISRUPTS) DNA(INDUCES) 25843623; 28636932; 32117957 4 2 0 prevents deubiquitination of FANCD2; inhibits dormant origin firing -PARVA PARVA Adaptor/scaffold; Motility/polarity/chemotaxis Q9NVD7 55742 11p15.3 human S8-p 4270099 MATSPQKsPSVPKSP molecular association, regulation; enzymatic activity, induced cell motility, induced; cell adhesion, induced ARHGEF7(INDUCES); PAK1(INDUCES) 15353548; 22955285 4 33 0 Matrix degradation, Src and MMP2 activity -LMNA lamin A/C Cytoskeletal P02545 4000 1q22 human S652-p 452607 SYLLGNSsPRTQSPQ activity, induced; intracellular localization 18815303 2 22 0 nuclear lamin disassemby -DYRK2 DYRK2 iso2 EC 2.7.12.1; KINASE; Kinase, protein; Protein kinase, CMGC; Protein kinase, dual-specificity (non-receptor) Q92630-2 8445 12q15 human S497-p 1874397818 ISKLPPPsSSASKLR cell cycle regulation; apoptosis, induced 34363019 1 1 0 -MAFA MAFA DNA-binding; Oncoprotein; Transcription factor; Tumor suppressor Q8NHW3 389692 8q24.3 human S65-p 5403102 PCSSVPSsPSFCAPS activity, induced; protein degradation cell differentiation, altered; transcription, induced 11416124; 35406570 9 0 0 activation of crystallin and NQO1 expression -Stxbp1 STXBP1 Vesicle P61765 25558 3p11 rat T574-p 454395 IGSTHILtPQKLLDT Sec1 molecular association, regulation STX1A(DISRUPTS) 15489225 3 0 0 -H2az1 H2AZ DNA-binding P0C0S6 51788 3|3 G3 mouse K121-ub 486331 HKSLIGKkGQQKTV_ Histone_H2A_C protein degradation 16687393 1 8 86 -ERG ERG DNA-binding; Oncoprotein; Transcription factor P11308 2078 21q22.2 human S96-p 4712353 KGGKMVGsPDTVGMN molecular association, regulation carcinogenesis, induced; cell motility, induced; transcription, induced PRRC2C iso2(DISRUPTS) 28887309; 33554122 4 5 0 -HINT1 HINT1 Cytoskeletal; EC 3.-.-.-; Hydrolase P49773 3094 5q23.3 human Y109-p 457442 SDGGQSVyHVHLHVL HIT cell growth, induced; transcription, induced 28394346 1 1 10 -F3 F3 Cell surface; Membrane protein, integral P13726 2152 1p21.3 human S290-p 451613 GQSWKENsPLNVS__ molecular association, regulation; ubiquitination; intracellular localization; protein conformation; phosphorylation cell motility, altered; cell growth, altered FLNA(INDUCES) 15630487; 18297283; 20076769; 21310953; 27599717; 29044292 11 1 0 promotes angiogenesis -Arhgef15 ephexin-5 GEF; GEF, Rac/Rho Q5FWH6 442801 11|11 B3 mouse S109-p 17546059 PVSRRSIsPEPAPCS activity, induced cytoskeletal reorganization 30485813 1 2 0 Suppression of hippocampal dendritic spine formation; RhoA activation -TPX2 TPX2 Cell cycle regulation; Microtubule-binding Q9ULW0 22974 20q11.21 human T72-p 460008 NLQQAIVtPLKPVDN intracellular localization cell cycle regulation 25688093 2 28 52 important for formation of a bipolar spindle -MAP3K7 TAK1 EC 2.7.11.25; KINASE; Kinase, protein; Protein kinase, Ser/Thr (non-receptor); Protein kinase, TKL O43318 6885 6q15 human T187-p 454704 CDIQTHMtNNKGSAA PK_Tyr_Ser-Thr intracellular localization; phosphorylation; enzymatic activity, induced carcinogenesis, induced; cell growth, induced; signaling pathway regulation; transcription, altered 10838074; 15590691; 17079228; 18299321; 19223549; 19393267; 20538596; 22307082; 31387937; 31511642; 35105963; 36270986 33 1 0 induces TAK1-ADAM17 signaling; induces MAPK-JNK and NFkB signaling pathways; induces MAPK and NF-kB signaling pathways by inducing phosphorylation of JNK and ERK -Foxo1 FOXO1A DNA-binding; Nuclear receptor co-regulator; Oncoprotein; Transcription factor Q9R1E0 56458 3 C|3 23.19 cM mouse S284-p 478910 GQEGPGDsPGSQFSK molecular association, regulation; intracellular localization transcription, inhibited DUSP6(INDUCES) 22503562; 22848439 4 26 1 -GAREM2 FAM59B Unknown function Q75VX8 150946 2p23.3 human Y429-p 28850312 APPAEIPyEELWAHQ molecular association, regulation cell differentiation, induced; signaling pathway regulation GRB2(INDUCES); SHP-2(INDUCES) 24003223 1 0 0 -SMAD2 SMAD2 DNA-binding; Transcription factor Q15796 4087 18q21.1 human S110-p 450144 SFSEQTRsLDGRLQV MH1 molecular association, regulation; intracellular localization SMAD3(INDUCES) 11027280 1 0 0 -LPIN1 LPIN1 EC 3.1.3.4; Phosphatase, lipid Q14693 23175 2p25.1 human Y398-p 1871177710 HLGADGVyLDDLTDM enzymatic activity, induced carcinogenesis, induced; cell growth, induced 33203880 1 1 0 Activity of PAP, increase glycolipid synthesis -CCR5 CCR5 GPCR, family 1; Membrane protein, integral; Membrane protein, multi-pass; Motility/polarity/chemotaxis; Receptor, GPCR; Receptor, cytokine P51681 1234 3p21.31 human S349-p 448724 STGEQEIsVGL____ molecular association, regulation; receptor desensitization, altered; receptor internalization, altered; activity, inhibited ARRB1(INDUCES); ARRB2(INDUCES) 10085131; 11782464; 12065593; 21148810 7 4 0 -LSP1 LSP1 Actin-binding; Motility/polarity/chemotaxis P33241 4046 11p15.5 human S252-p 479435 PKLARQAsIELPSMA Caldesmon intracellular localization 17481585 3 41 175 in chemotaxing neutrophils -MZF1 MZF-1 C2H2-type zinc finger protein; DNA-binding; Transcription factor P28698 7593 19q13.43 human T134-p 27455496 GGPRRWVtVQVQGQE carcinogenesis, altered 31301870 1 1 0 alters cancer cell stemness -PPARA PPAR-alpha DNA-binding; Nuclear receptor; UBIQUITIN LIGASE Q07869 5465 22q13.31 human S12-p 1789802 ESPLCPLsPLEAGDL transcription, inhibited 18079279; 21224484 3 0 0 -ACADVL ACADVL EC 1.3.8.9; Lipid Metabolism - fatty acid; Mitochondrial; Oxidoreductase P49748 37 17p13.1 human K482-sc 33359415 QGCMDKGkELSGLGS molecular association, regulation CRLS1(INDUCES) 25811481 1 1 0 both SIRT3 and SIRT5 KO show reduced afinity for CRLS1 -ITGB3 ITGB3 Cell adhesion; Membrane protein, integral; Motility/polarity/chemotaxis P05106 3690 17q21.32 human S778-p 457413 PLYKEATsTFTNITY Integrin_b_cyt molecular association, regulation; protein conformation; activity, inhibited cell motility, altered; cell adhesion, altered ITGA4(DISRUPTS) 10330414; 18806263 3 0 0 -RHOA RHOA G protein; G protein, monomeric; G protein, monomeric, Rho; Motility/polarity/chemotaxis; Oncoprotein P61586 387 3p21.31 human T100-p 53332704 ENIPEKWtPEVKHFC Ras activity, induced; intracellular localization cytoskeletal reorganization ROCK1(INDUCES) 26816343 1 0 0 enhanced actin stress fiber formation, distributed in the cytoplasm with or without EGF stimulation -MARK1 MARK1 EC 2.7.11.1; EC 2.7.11.26; KINASE; Kinase, protein; Protein kinase, CAMK; Protein kinase, Ser/Thr (non-receptor) Q9P0L2 4139 1q41 human T215-p 456037 TVGNKLDtFCGSPPY Pkinase signaling pathway regulation 24362629 4 45 33 -Myocd myocardin Cell development/differentiation; Transcription factor Q8VIM5 214384 11|11 B3 mouse S636-p 3627511 PQCSPQHsPLGGLKS transcription, inhibited 16141410 1 0 0 -Prkcz PKCZ EC 2.7.11.13; KINASE; Kinase, protein; Protein kinase, AGC; Protein kinase, Ser/Thr (non-receptor) Q02956 18762 4 E2|4 86.17 cM mouse T560-p 447572 TSEPVQLtPDDEDVI Pkinase_C activity, induced; enzymatic activity, induced 15665819; 23354168 13 8 0 -SP1 SP1 C2H2-type zinc finger protein; DNA-binding; Transcription factor P08047 6667 12q13.13 human T453-p 448226 SGPIIIRtPTVGPNG molecular association, regulation carcinogenesis, induced; cell growth, induced; transcription, induced; signaling pathway regulation; transcription, inhibited; transcription, altered NFkB-p65(INDUCES) DNA(INDUCES) 11904305; 14593115; 14744793; 20150555; 32615164 7 0 0 regulates ERK2/Sp1-OSMR pathway -TP53 p53 Activator; DNA-binding; Motility/polarity/chemotaxis; Nuclear receptor co-regulator; Transcription factor; Tumor suppressor P04637 7157 17p13.1 human R249-p 394791401 CMGGMNRrPILTIIT P53 protein stabilization; molecular association, regulation; intracellular localization carcinogenesis, induced; carcinogenesis, altered; cell growth, induced; transcription, induced; signaling pathway regulation Myc(INDUCES); STAT1(INDUCES); PIN1(INDUCES) 29225033; 31747859; 32820905 3 0 0 CDK4/Cyclin D1-c-Myc pathway; rDNA transcription key for ribosomal biogenesis; CDK6-p53RS-PIN1-STAT1 signaling for cell proliferation; inhibits FBW7A ubiquitin ligase activity; PIN1 enhances nuclear localization of phosphorylated R249S mutation, correlated with HBV infection -NFKB2 NFkB-p100 DNA-binding; Oncoprotein; Transcription factor Q00653 4791 10q24.32 human S222-p 3193889 QPIHDSKsPGASNLK molecular association, regulation transcription, altered REL(INDUCES); Bcl-3(DISRUPTS); NFkB-p100(DISRUPTS) 20513428 1 8 0 -Dppa4 DPPA4 Cell development/differentiation Q8CCG4 73693 16|16 B5 mouse K143-sm 1877126902 KTAHKKMkTEPGEES transcription, inhibited 32937131 1 1 0 -RBL1 Rb-like 1 Transcription, coactivator/corepressor; Tumor suppressor P28749 5933 20q11.23 human S964-p 451297 MMDAPPLsPFPHIKQ Rb_C molecular association, regulation cell growth, altered E2F4(DISRUPTS) 11884610; 12006580 2 14 14 -STAT5A STAT5A DNA-binding; Motility/polarity/chemotaxis; Oncoprotein; Transcription factor P42229 6776 17q21.2 human S726-p 448749 TYMDQAPsPAVCPQA intracellular localization carcinogenesis, induced; cell growth, induced; apoptosis, inhibited; transcription, altered 21716071; 34188118; 36342456 19 1 0 -ERF ERF DNA-binding; Transcription factor P50548 2077 19q13.2 human S251-p 456968 PLSPFPVsPLAGPGS intracellular localization cell cycle regulation 10330152; 14729966 2 2 1 -Dgkg DGKG EC 2.7.1.107; Kinase, lipid; Lipid Metabolism - glycerolipid; Lipid Metabolism - glycerophospholipid; Motility/polarity/chemotaxis P49620 25666 11q23 rat S779-p 471078 PQKSSFFsLRRKSRS enzymatic activity, induced 16905533 1 6 1 -OSBP OSBP Lipid-binding P16258 rabbit S381-p 468341 LGHKRTGsNISGASS molecular association, regulation; intracellular localization; phosphorylation VAPA(DISRUPTS) 11441133; 22875984 2 46 1 phosphorylation of downstream serine residues. S381A/S3D double mutant has enhanced binding and altered localization. Regulation of sphingomyelin synthesis. -CTNNB1 CTNNB1 Actin-binding; Cell adhesion; Motility/polarity/chemotaxis; Nuclear receptor co-regulator; Oncoprotein; Transcription factor P35222 1499 3p22.1 human S246-p 469995 ALVKMLGsPVDSVLF Arm protein stabilization; molecular association, regulation; intracellular localization; protein conformation transcription, induced PIN1(INDUCES) 17009320; 26740630 3 0 0 nuclear retention -Hdac2 HDAC2 DEACETYLASE; Deacetylase; EC 3.5.1.98; Nuclear receptor co-regulator; Transcription, coactivator/corepressor P70288 15182 10 19.44 cM|10 B1 mouse S424-p 467980 CDEEFSDsEDEGEGG enzymatic activity, induced 21576649 4 73 49 -MECOM EVI1 C2H2-type zinc finger protein; Methyltransferase, protein lysine, predicted; Oncoprotein; Transcription regulation; Transcription, coactivator/corepressor Q03112 2122 3q26.2 human S1037-p 482637 IGNSNHGsQSPRNVE molecular association, regulation cell motility, induced; cell growth, induced; transcription, induced DNA(INDUCES) 23858473 1 6 0 -RAF1 RAF1 EC 2.7.11.1; KINASE; Kinase, protein; Oncoprotein; Protein kinase, Ser/Thr (non-receptor); Protein kinase, TKL P04049 5894 3p25.2 human S619-p 5822317 SLPKINRsASEPSLH enzymatic activity, induced 8288587 1 5 1 -YAP1 YAP1 Oncoprotein; Transcription, coactivator/corepressor P46937 10413 11q22.1 human S289-p 3190663 PPPLAPQsPQGGVMG molecular association, regulation cell cycle regulation; carcinogenesis, induced; cell motility, induced; apoptosis, inhibited; cytoskeletal reorganization TEAD4(DISRUPTS) 24101154; 24812269 4 24 1 -PTTG1 Securin Cell cycle regulation; Oncoprotein O95997 9232 5q33.3 human S171-p 5829579 PSPVKMPsPPWESNL Securin protein stabilization; molecular association, regulation; phosphorylation carcinogenesis, altered; transcription, induced; signaling pathway regulation CTNNB1(INDUCES) 37400529 1 0 1 induces GSK3B dephosphorylation, regulates Wnt/?-catenin signaling -LEO1 LEO1 Transcription regulation Q8WVC0 123169 15q21.2 human S91-p 1271628700 SDNRSEAsERSDHED molecular association, regulation; intracellular localization carcinogenesis, inhibited; cell growth, inhibited; apoptosis, induced; transcription, inhibited; signaling pathway regulation CTNNB1(DISRUPTS) 30305722 1 1 0 -ARHGAP24 ARHGAP24 GAP; GAP, Rac/Rho; Motility/polarity/chemotaxis Q8N264 83478 4q21.23-q21.3 human S413-p 12518707 SVHKLDVsRSPPLMV activity, induced cytoskeletal reorganization 16862148 1 4 0 membrane blebbing -Kcnk2 TREK-1 Channel, potassium; Membrane protein, integral; Membrane protein, multi-pass P97438 16526 1|1 H6 mouse S366-p 457099 TSVKRKLsAELAGNH activity, induced 11560940 1 2 2 increases open probability of the (K+) channel -AMOT AMOT Q4VCS5 154796 Xq23 human S175-p 28699604 QGHVRSLsERLMQMS protein stabilization; molecular association, regulation; ubiquitination; intracellular localization cell growth, inhibited; cytoskeletal reorganization; cell motility, inhibited; transcription, inhibited; signaling pathway regulation ACTA1(DISRUPTS); ACTB(DISRUPTS); 14-3-3 gamma(INDUCES); YAP1(INDUCES); ITCH(INDUCES); Merlin(INDUCES) 24101513; 24106267; 24225952; 28464980; 29317530 8 0 0 S175A mutant nuclear localization, S175E cytoplasm and cell membrane localization, localization of complex -Smad4 SMAD4 DNA-binding; Nuclear receptor co-regulator; Transcription, coactivator/corepressor P97471 17128 18 E2|18 49.51 cM mouse T276-p 449628 GSRTAPYtPNLPHHQ intracellular localization transcription, induced 12801888 3 0 0 -LSM4 LSM4 RNA-binding; Spliceosome Q9Y4Z0 25804 19p13.11 human R109-m2 15381284 RGMGGAGrGVFGGRG molecular association, regulation SMN(INDUCES) 11720283 1 1 3 -Mlxipl ChREBP Transcription factor Q8VIP2 171078 12q12 rat S196-p 451393 KKRLRKSsREGDFLA molecular association, regulation; intracellular localization; activity, inhibited transcription, altered 14-3-3 beta(INDUCES); KPNA1(INDUCES); KPNA2(DISRUPTS) 11698644; 18606808; 21665952 5 8 1 inhibits nuclear localization of ChREBP under low glucose conditions -Ptpre PTPRE EC 3.1.3.48; Membrane protein, integral; Motility/polarity/chemotaxis; PHOSPHATASE; Receptor protein phosphatase, tyrosine P49446 19267 7 F3|7 81.27 cM mouse Y695-p 450705 FIDIFSDyANFK___ molecular association, regulation; enzymatic activity, induced cell growth, altered GRB2(INDUCES); TUBA4A(INDUCES); PTPRE(DISRUPTS) 10490839; 17486066; 17709387 4 22 597 Binding to tubulin decreases the cyt-PTPRE phosphatase activity.; reduced dimerization of glycosylated PTPRE mediated by HER2; essential for activation of Src by dephosphorylation -Atat1 ATAT1 iso2 ACETYLTRANSFERASE; Acetyltransferase; EC 2.3.1.108 Q8K341-2 73242 17|17 B1 mouse K146-ac 27581501 LFQHMLQkERVEPHQ Acetyltransf_16 enzymatic activity, induced 23275437 1 1 0 -MSX1 MSX1 DNA-binding; Motility/polarity/chemotaxis P28360 4487 4p16.2 human K133-sm 12004421 LPEDALVkAESPEKP cell differentiation, inhibited; transcription, inhibited 16600910 2 0 0 PIAS1 binding to MSX1 is required for inhibiting cell differentiation and transcriptional repression, but sumoylation is not required -CRYAA CRYA1 Chaperone; Heat shock protein P02489 1409 21q22.3 human K70-ac 459001 EVRSDRDkFVIFLDV HSP20 activity, induced; molecular association, regulation; protein conformation apoptosis, inhibited 22120592; 23508955 2 4 0 -UNG UNG EC 3.2.2.27; Hydrolase P13051 7374 12q24.11 human T6-p 453426 __MIGQKtLYSFFSP molecular association, regulation PCNA(DISRUPTS) 28746850 1 1 0 -Nefl NFL Cytoskeletal P19527 83613 15p12 rat S56-p 451024 SSLSVRRsYSSSSGS Filament_head cytoskeletal reorganization 22705628 9 3 1 -Rela NFkB-p65 DNA-binding; Nuclear receptor co-regulator; Transcription factor Q04207 19697 19 A|19 4.34 cM mouse S311-p 449966 RTYETFKsIMKKSPF molecular association, regulation apoptosis, inhibited; transcription, induced p300(INDUCES) 12881425 17 2 1 -Egfr EGFR EC 2.7.10.1; KINASE; Kinase, protein; Membrane protein, integral; Oncoprotein; Protein kinase, TK; Protein kinase, tyrosine (receptor) Q01279 13649 11 A2|11 9.41 cM mouse Y1069-p 448056 EDAFLQRySSDPTGA protein degradation; molecular association, regulation; phosphorylation cell motility, altered; apoptosis, inhibited CBL(INDUCES) 10635327; 16123117; 17139251 45 18 117 promotes phosphorylation of Cbl -PCBP2 hnRNP E2 RNA splicing; RNA-binding Q15366 5094 12q13.13 human S189-p 482917 YRPKPSSsPVIFAGG protein stabilization; molecular association, regulation cell differentiation, inhibited; translation, inhibited RNA(INDUCES) 17475908 2 56 11 -Cacna1d CACNA1D Channel, calcium; Membrane protein, integral; Membrane protein, multi-pass P27732 29716 16p16 rat S1816-p 6062701 AAHGKRPsIGDLEHV CAC1F_C activity, induced 19074150 1 0 0 -Gabrg2 GABRG2 Channel, chloride; Channel, ligand-gated; Membrane protein, integral; Membrane protein, multi-pass; Transporter; Transporter, ion channel P22723 14406 11 A5|11 24.8 cM mouse S365-p 486436 FVSNRKPsKDKDKKK Neur_chan_memb receptor desensitization, altered 17875639 9 0 0 -NCOA3 SRC-3 ACETYLTRANSFERASE; Acetyltransferase; EC 2.3.1.48; Motility/polarity/chemotaxis; Nuclear receptor co-regulator; Transcription, coactivator/corepressor Q9Y6Q9 8202 20q13.12 human S1330-p 3217872 PAFGRVSsPPNAMMS DUF1518 molecular association, regulation carcinogenesis, inhibited; cell growth, inhibited; transcription, inhibited; signaling pathway regulation ATF-4(DISRUPTS) DNA(DISRUPTS) 31066068 2 14 0 Dyrk3/NCOA3/ATF4 signaling pathway -Rb1 Rb Nuclear receptor co-regulator; Oncoprotein; Transcription, coactivator/corepressor; Tumor suppressor P13405 19645 14 38.73 cM|14 D3 mouse S561-p 450021 SLAWLSDsPLFDLIK RB_A molecular association, regulation E2F1(DISRUPTS) 10207050 6 0 0 -SIRT1 SIRT1 Apoptosis; DEACETYLASE; Deacetylase; EC 3.5.1.-; Nuclear receptor co-regulator Q96EB6 23411 10q21.3 human K734-sm 1968605 INEAISVkQEVTDMN acetylation; enzymatic activity, induced apoptosis, inhibited; transcription, inhibited 17934453 2 1 0 induces deacetylation of p53 -Adra2a ADRA2A GPCR, family 1; Membrane protein, integral; Membrane protein, multi-pass; Receptor, GPCR P22909 25083 1q55 rat T388-p 467298 QNREKRFtFVLAVVI 7tm_1; TM activity, inhibited 15118347 1 0 0 -HSPA8 HSC70 Chaperone; Heat shock protein; Nucleolus; RNA-binding P11142 3312 11q24.1 human K561-m3 3898513 EDEKLQGkINDEDKQ HSP70 molecular association, regulation SNCA(DISRUPTS) 23921388 3 5 5 -ACSL4 ACSL4 EC 6.2.1.3; Ligase; Lipid Metabolism - fatty acid; Membrane protein, integral O60488 2182 Xq23 human K388-ub 21128158 IYKNVMSkVQEMNYI AMP-binding protein degradation 37428466 1 4 0 inhibition of ACSL4-driven lipid peroxidation and ferroptosis is necessary for CDK1 to promote oxaliplatin resistance in CRC -Rtn4 Nogo iso2 Cell development/differentiation; Endoplasmic reticulum; Inhibitor; Membrane protein, integral; Membrane protein, multi-pass; Motility/polarity/chemotaxis Q9JK11-2 rat S16-p 468313 LVSSSTDsPPRPPPA protein degradation apoptosis, altered 18072206 1 51 1 Phosphorylation regulates clevage of Nogo B. -RPS6KB1 p70S6K iso2 EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, AGC; Protein kinase, Ser/Thr (non-receptor); Translation P23443-2 6198 17q23.1 human T389-p 448607 NQVFLGFtYVAPSVL Pkinase_C phosphorylation; enzymatic activity, induced carcinogenesis, induced 18326039; 25936802; 37078777 476 9 1 reduces sensitivity to sunitinib; induces S6 phosphorylation -BRAF BRAF EC 2.7.11.1; KINASE; Kinase, protein; Oncoprotein; Protein kinase, Ser/Thr (non-receptor); Protein kinase, TKL P15056 673 7q34 human T599-p 447807 IGDFGLAtVKSRWSG PK_Tyr_Ser-Thr molecular association, regulation; protein conformation; enzymatic activity, induced carcinogenesis, induced; cell differentiation, altered; cell growth, induced; transcription, induced; transcription, altered; cell growth, altered BRAF(NOT_REPORTED) 11032810; 11293329; 15035987; 15710605; 18451171; 23907581; 26657898 12 0 0 phosphorylation at T599 and S602 and K578 ubiquitination mediate ERK activation -Nphs1 NPHS1 Cell adhesion; Immunoglobulin superfamily; Membrane protein, integral Q9QZS7 54631 7|7 B1 mouse Y1208-p 469565 PGVWGPLyDEVQMDP molecular association, regulation cytoskeletal reorganization NCK1(INDUCES) 18212058; 34391780 16 1 0 induce podocyte repair -NFE2L2 NRF2 DNA-binding; Transcription factor Q16236 4780 2q31.2 human K533-ac 7106322 EQDLDHLkDEKEKLL bZIP_Maf molecular association, regulation transcription, induced DNA(INDUCES) 19273602 1 1 0 -Canx Calnexin Calcium-binding; Endoplasmic reticulum; Membrane protein, integral; Motility/polarity/chemotaxis P35565 29144 10q22 rat S563-p 456360 EEDGGTGsQDEEDSK molecular association, regulation; activity, inhibited SERCA2(INDUCES) 10851021 7 85 48 inhibition of cytosolic Ca2+ waves -Npr1 ANPA EC 4.6.1.2; Guanylyl cyclase; KINASE; Kinase, protein; Lyase; Membrane protein, integral; Nucleotide Metabolism - purine; Protein kinase, RGC; Protein kinase, dual-specificity (receptor); Receptor, misc. P18910 24603 2q34 rat S501-p 25528503 QLEKELVsELWRVRW receptor desensitization, induced; enzymatic activity, induced 22590601 2 0 0 -NDUFA12 NDUFA12 EC 1.6.5.3; EC 1.6.99.3; Mitochondrial; Oxidoreductase Q9UI09 55967 12q22 human T142-p 33402204 QEWIPPStPYK____ activity, induced cell cycle regulation 24746669 1 1 0 increases mitochondrial respiration for G/2M transition -YWHAB 14-3-3 beta Adaptor/scaffold P31946 7529 20q13.12 human K51-ac 474927 NLLSVAYkNVVGARR 14-3-3 molecular association, regulation; intracellular localization; activity, inhibited cell differentiation, induced SYNPO(DISRUPTS) 23840712; 34379822 2 5 15 osteogenesis -RANBP2 RANBP2 Adaptor/scaffold; EC 5.2.1.8; EC 6.3.2.-; Ligase; Nuclear export; Nucleoporin; SUMO LIGASE; SUMO conjugating system; SUMO ligase P49792 5903 2q13 human S2251-p 468569 HASPLASsPVRKNLF molecular association, regulation; intracellular localization BICD2(INDUCES) 26051540 2 29 0 targets BicD2 to the NE of RGP cells to induce apical nuclear migration -SRPK2 SRPK2 EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, CMGC; Protein kinase, Ser/Thr (non-receptor) P78362 6733 7q22.3 human S494-p 483631 HDRSRTVsASSTGDL intracellular localization transcription, induced 29153836 1 54 18 transcription of genes involved in de novo lipid synthesis; nuclear translocation -Dlg1 DLG1 Adaptor/scaffold; Motility/polarity/chemotaxis Q62696 25252 11q22 rat S431-p 4749386 QSVDNHVsPSSYLGQ PDZ_assoc molecular association, regulation; intracellular localization cytoskeletal reorganization GKAP1(DISRUPTS) 15729360 1 0 1 -ADRA1D ADRA1D GPCR, family 1; Membrane protein, integral; Membrane protein, multi-pass; Receptor, GPCR P25100 146 20p13 human S518-p 1346843000 RAKVSSLsHKIRAGG receptor internalization, induced; molecular association, regulation; intracellular localization; receptor internalization, altered signaling pathway regulation ARRB1(INDUCES) 29551601; 30419287 2 1 0 triggers the calcium signaling pathway; regulates ERK signaling pathway, induces calcium signaling de-sensitization -Kras KRas G protein; G protein, monomeric; G protein, monomeric, Ras; Motility/polarity/chemotaxis; Oncoprotein P32883 16653 6 G3|6 77.37 cM mouse K147-ac 56423802 PFIETSAkTRQRVED Ras enzymatic activity, altered carcinogenesis, induced; cell growth, induced; signaling pathway regulation 27637077 2 2 0 regulates KRas-downstream oncogenic pathway-Raf/MEK/ERK pathway -PALLD palladin Cytoskeletal; Motility/polarity/chemotaxis Q8WX93 23022 4q32.3 human S1118-p 468361 VRRPRSRsRDSGDEN cell motility, altered; cytoskeletal reorganization 20471940 1 40 71 -Gabrg2 GABRG2 Channel, chloride; Channel, ligand-gated; Membrane protein, integral; Membrane protein, multi-pass; Transporter; Transporter, ion channel Q6PW52 29709 10q21 rat S365-p 486436 FVSNRKPsKDKDKKK Neur_chan_memb receptor internalization, induced; intracellular localization endocytosis, induced 20823221; 34657931; 34936876 9 0 0 -Tp53 p53 Activator; DNA-binding; Motility/polarity/chemotaxis; Nuclear receptor co-regulator; Transcription factor; Tumor suppressor P02340 22059 11 B3|11 42.83 cM mouse K379-ac 458977 QSTSRHKkTMVKKVG activity, induced; protein stabilization apoptosis, induced; transcription, induced; transcription, inhibited 10990460; 12356735; 17581637; 25758227; 33323382 216 10 0 P53K Q/- mice died prematurely due to anemia, loss of hematopoiesis stem cells, Loss of stem cells in the testis, activation in p53 KQ/- mice without robust p53 stabilization,p53-KQ/- mutant leads to effective suppression of tumor development in a pancreatic ductal adenocarcinoma mouse model, mutant proteins extended the life-span of a PDAC mouse model -MEFV pyrin Actin-binding O15553 4210 16p13.3 human S208-p 455897 VRLRRNAsSAGRLQG molecular association, regulation; intracellular localization; activity, inhibited 14-3-3 theta(INDUCES); 14-3-3 epsilon(INDUCES) 15934090; 27270401; 36223753 8 1 2 -MAP3K2 MEKK2 EC 2.7.11.25; KINASE; Kinase, protein; Protein kinase, STE; Protein kinase, Ser/Thr (non-receptor) Q9Y2U5 10746 2q14.3 human T524-p 1904501 GMKSVTGtPYWMSPE Pkinase phosphorylation; enzymatic activity, induced transcription, altered 16362041 1 1 0 Mutation of S520A inhibits activation and is the key residue. Double mutation of T522A,T524A reduces activation effect. T522A seems to have the least effect of the three single mutations. The triple STT to AAA mutation is akin to kinase dead. Activation leads to Erk5 and JNKK2 phosphorylation/activation. -PARP1 PARP1 DNA repair, damage; EC 2.4.2.30; Nuclear envelope; Nuclear receptor co-regulator; Nucleolus; Transferase P09874 142 1q42.12 human K221-ub 21180920 DGVDEVAkKKSKKEK cell motility, induced; cell growth, induced; apoptosis, inhibited; DNA repair, inhibited; signaling pathway regulation 36088509 1 1 0 HECTD3 activates the EGFR-mediated signalling pathway through PARP1. -SHCBP1 SHCBP1 Adaptor/scaffold Q8NEM2 79801 16q11.2 human S273-p 3206802 SSLSNCNsDSEQENI intracellular localization cell cycle regulation; carcinogenesis, induced; cell motility, induced; cell growth, induced 33990570; 35013128 2 7 1 -STAT2 STAT2 DNA-binding; Transcription factor P52630 6773 12q13.3 human T387-p 60152500 TSNQKTLtPEKGQSQ STAT_bind activity, inhibited cell growth, induced; transcription, inhibited 27852626 1 1 0 -ZNF322 ZNF322A C2H2-type zinc finger protein; Transcription factor Q6U7Q0 79692 6p22.2 human T234-p 1246856 IVHKRVHtGEKPYKC activity, induced; molecular association, regulation carcinogenesis, induced; chromatin organization, altered; cell motility, induced; cell growth, induced; transcription, induced DNA(INDUCES) 31399647 1 5 5 chromatin binding; increases recruitment to ADD1 and CCND1 promoters -TRPM4 TRPM4 Membrane protein, integral; Membrane protein, multi-pass Q8TD43 54795 19q13.33 human S1145-p 12559511 RDKRESDsERLKRTS activity, induced 15590641 1 0 0 -ACBD5 ACBD5 iso2 Lipid-binding; Membrane protein, integral Q5T8D3-2 91452 10p12.1 human T258-p 1876128606 VTGIQHLtSDSDSEV molecular association, regulation VAPB(INDUCES) 35019937 1 1 0 -SRSF1 SF2 RNA splicing; RNA-binding; Spliceosome Q07955 6426 17q22 human R97-m1 1308911 RSGRGTGrGGGGGGG intracellular localization RNA splicing, induced; RNA stability, inhibited; translation, induced 20308322 1 8 49 prevents SF2 nuclear import and splicing of target genes, and translation is increased in the cytoplasm -BDNF BDNF Cell development/differentiation; Cytokine; Secreted; Secreted, signal peptide P23560 627 11p14.1 human T62-p 30259809 GLTSLADtFEHVIEE cell differentiation, induced; transcription, induced 23712400 1 0 0 increases OPN and BMP2 mRNA expression -PDHA1 PDHA1 Amino Acid Metabolism - valine, leucine and isoleucine biosynthesis; Carbohydrate Metabolism - butanoate; Carbohydrate Metabolism - citrate (TCA) cycle; Carbohydrate Metabolism - glycolysis and gluconeogenesis; Carbohydrate Metabolism - pyruvate; EC 1.2.4.1; Mitochondrial; Oxidoreductase P08559 5160 Xp22.12 human Y301-p 454753 MSDPGVSyRTREEIQ E1_dh molecular association, regulation carcinogenesis, induced; cell growth, induced Other(DISRUPTS) 25104357 2 36 1386 inhibits pyruvate binding -Hdgf HDGF Cytokine; Transcription regulation P51859 15191 3 F1|3 38.78 cM mouse S165-p 452720 AGDVLEDsPKRPKES protein processing; intracellular localization 21087088 2 117 29 positively regulates HDGF secretion by inhibiting its N-terminal truncation -Smad3 SMAD3 DNA-binding; Nuclear receptor co-regulator; Transcription factor Q8BUN5 17127 9|9 C mouse S204-p 451178 NHSMDAGsPNLSPNP protein stabilization; molecular association, regulation; enzymatic activity, induced apoptosis, induced; transcription, induced; signaling pathway regulation 29700281 17 0 0 increase MELK stability and activity; regulate ASK1/TGF-beta/p53 signaling pathways -Tnp2 TP2 DNA-binding P11101 24840 10q11 rat T101-p 450901 AVRRRKRtHRAKRRS TP2 intracellular localization 14514679 1 0 0 -LIPE HSL EC 3.1.1.79; Lipase Q05469 3991 19q13.2 human S950-p 450194 EGFHPRRsSQGATQM Abhydrolase_3 molecular association, regulation; enzymatic activity, induced FABP4(INDUCES) 17785468; 19018281 8 5 4 -Syn1 SYN1 Vesicle O88935 20964 X A1.3|X 16.37 cM mouse S605-p 450236 AGPTRQAsQAGPGPR neural plasticity; signaling pathway regulation 31242289; 36207442 21 10 11 -Junb JunB Motility/polarity/chemotaxis; Oncoprotein; Transcription factor P24898 24517 19q11 rat S186-p 1814003 YTNLSSYsPASAPSG Jun protein degradation cell cycle regulation; transcription, altered 10790372 1 0 0 Phosphorylation promoted degradation during the G2-M transition. JunB inhibition of cyclin D1 transcription is relieved by JunB protein degradation. -Cd83 CD83 Membrane protein, integral O88324 12522 13 A4|13 21.6 cM mouse K168-ub 9381801 SIFPDISkPGTEQAF protein degradation 19542455 1 0 0 -PPP1R2 PPP1R2 Inhibitor; Motility/polarity/chemotaxis; Protein phosphatase, regulatory subunit P41236 5504 3q29 human T73-p 449051 MKIDEPStPYHSMMG IPP-2 intracellular localization; protein conformation; enzymatic activity, induced cell cycle regulation PPP1R2(INDUCES) 18062707; 22982244; 9405437 11 4 0 -H1-4 H1E DNA-binding P10412 3008 6p22.2 human K26-ac 9926962 PVKKKARkSAGAAKR cell cycle regulation 24873882 1 0 1 -PARD3 PAR3-alpha Adaptor/scaffold; Motility/polarity/chemotaxis Q8TEW0 56288 10p11.22-p11.21 human S144-p 455668 PLHVRRSsDPALIGL molecular association, regulation cytoskeletal reorganization GAB1(DISRUPTS); 14-3-3 zeta(INDUCES) 14653998; 22883624 4 21 26 -TSC2 TSC2 Cell cycle regulation; GAP; GAP, misc.; Nuclear receptor co-regulator; Tumor suppressor P49815 7249 16p13.3 human S1254-p 448807 TALYKSLsVPAASTA molecular association, regulation 14-3-3 beta(INDUCES) 12582162 6 23 14 -Pkmyt1 Myt1 EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, Other; Protein kinase, Ser/Thr (non-receptor); Protein kinase, dual-specificity (non-receptor) Q95YJ1 starfish S75-p 449752 ESRPRAVsFRQSEPS activity, inhibited cell cycle regulation 11802161 1 0 0 -YAP1 YAP1 iso2 Oncoprotein; Transcription, coactivator/corepressor P46937-2 10413 11q22.1 human S164-p 471933 AQHLRQSsFEIPDDV activity, inhibited cell differentiation, induced; cell growth, inhibited; transcription, inhibited 23027127; 23752589 13 16 45 -MYC Myc DNA-binding; Nucleolus; Oncoprotein; Transcription factor P01106 4609 8q24.21 human S359-p 25173074 SNNRKCTsPRSSDTE Myc_N carcinogenesis, inhibited; transcription, inhibited 24030976 2 7 0 -SENP3 SENP3 DESUMOYLASE; EC 3.4.22.68; Nucleolus; Protease; Sumo-specific protease Q9H4L4 26168 17p13.1 human T142-p 36438200 MLLYSKStSLTFHWK molecular association, regulation; intracellular localization NPM1(INDUCES) 25288641 1 1 0 ribosome biogenesis-28S rRNA maturation -Itgb2 ITGB2 Cell adhesion; Cell surface; Membrane protein, integral; Motility/polarity/chemotaxis; Receptor, misc. P11835 16414 10 C1|10 39.72 cM mouse T762-p 450185 LFKSATTtVMNPKFA Integrin_b_cyt cell motility, induced; cell adhesion, induced 23823319 3 0 0 T-cell homing to lymphocytes -Stmn2 STMN2 Cytoskeletal P21818 84510 2q23 rat S50-p 455606 KQINKRAsGQAFELI Stathmin molecular association, regulation cytoskeletal reorganization TUBA1A(INDUCES); TUBB(INDUCES) 15825189; 9525956 5 5 0 -Lat2 LAB Adaptor/scaffold; Membrane protein, integral Q9JHL0 56743 5|5 G2 mouse Y160-p 450645 GVEDFEDyQNSVSIH LAT2 signaling pathway regulation 22308309 3 8 151 plays a negative role in TCR and FcRI-mediated and no role in LPS-mediated signaling -Bad BAD Apoptosis Q61337 12015 19|19 A mouse S136-p 447862 PFRGRSRsAPPNLWA Bcl-2_BAD activity, induced; molecular association, regulation; intracellular localization; activity, inhibited; phosphorylation apoptosis, altered; apoptosis, inhibited; cell growth, altered Bcl-xL(NOT_REPORTED); JNK1(DISRUPTS); 14-3-3 zeta(INDUCES); PKACA(INDUCES); 14-3-3 beta(NOT_REPORTED); PPP2CA(INDUCES); 14-3-3 beta(INDUCES); 14-3-3 theta(INDUCES); Bcl-2(DISRUPTS); PKCA(INDUCES); Bcl-xL(DISRUPTS) 10611223; 10777478; 10887134; 10949026; 10996800; 11526496; 11723239; 12754297; 12897128; 12944463; 14670836; 15123689; 16009721; 16103085; 16403219; 19217411; 20813501; 22103330; 23332762; 34023385; 8929531; 9346240; 9651683 124 55 216 -Ntrk2 TrkB EC 2.7.10.1; KINASE; Kinase, protein; Membrane protein, integral; Protein kinase, TK; Protein kinase, tyrosine (receptor) Q63604 25054 17p14 rat Y515-p 448813 PVIENPQyFGITNSQ molecular association, regulation; phosphorylation; enzymatic activity, induced translation, altered; signaling pathway regulation SHC3(INDUCES); SHC1(INDUCES); SHC2(INDUCES) 10196222; 10533983; 12006576; 15362724; 16223723; 16573649; 22563458 23 2 40 c-fos protein synthesis induced by BDNF; activation of PLC-gamma1 and MAPK/PI3K signal transduction pathways; Y515F attenuates phosphorylation levels of FRS2, TrkB autophosphorylation levels, and ERK activation after BDNF treatment. -PGK1 PGK1 Carbohydrate Metabolism - glycolysis and gluconeogenesis; EC 2.7.2.3; KINASE; Kinase, other P00558 5230 Xq21.1 human K323-ac 479484 CGPESSKkYAEAVTR PGK enzymatic activity, induced carcinogenesis, induced; cell growth, induced 27774669 2 5 22 -Rps5 RPS5 RNA-binding; Ribosomal; Translation P97461 20103 7|7 A1 mouse S24-p 9819906 IKLFGKWsTDDVQIN intracellular localization 19631221 1 0 0 -TSPY1 TSPY1 Cancer Testis Antigen (CTA) Q01534 7258 Yp11.2 human T300-p 460704 PPEEGTEtSGDSQLL protein stabilization; intracellular localization 16426576 1 0 0 important for the nuclear transport -WNK4 WNK4 EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, Other; Protein kinase, Ser/Thr (non-receptor) Q96J92 65266 17q21.2 human Y1115-p 40407607 PVWMNYSySSLCLSS activity, inhibited 25805816 1 1 0 WNK4 inhibition of ROMK channels -Tec TEC EC 2.7.10.2; KINASE; Kinase, protein; Protein kinase, TK; Protein kinase, tyrosine (non-receptor) P24604 21682 5 C3.2|5 38.44 cM mouse Y518-p 447891 RYVLDDQyTSSSGAK PK_Tyr_Ser-Thr molecular association, regulation; enzymatic activity, induced DOK1(INDUCES) 20697350 1 20 322 -CACNA1C CACNA1C iso12 Channel, calcium; Membrane protein, integral; Membrane protein, multi-pass Q13936-12 775 12p13.33 human Y2134-p 1043301 ELQDSRVyVSSL___ signaling pathway regulation 20128810 2 0 0 mutation (Y to F) prevents depolarization-induced CRE activation -STAT2 STAT2 DNA-binding; Transcription factor P52630 6773 12q13.3 human Y631-p 479848 LIYSVQPyTKEVLQS SH2 apoptosis, inhibited 17442890 1 0 0 STAT2 Y631F mutant promotes IFN-alpha-induced apoptosis -HIF1A HIF1A Autophagy; DNA-binding; Transcription factor Q16665 3091 14q23.2 human S576-p 17331801 DDDFQLRsFDQLSPL HIF-1 protein degradation 20889502 1 1 0 -FOXM1 FOXM1 DNA-binding; Transcription factor Q08050 2305 12p13.33 human K478-sm 31898503 PHLARPIkVESPPLE protein degradation; ubiquitination; intracellular localization cell cycle regulation; cell growth, inhibited; transcription, inhibited 24362530 2 0 0 -GATA1 GATA1 DNA-binding; Transcription factor P15976 2623 Xp11.23 human S310-p 451231 QTRNRKAsGKGKKKR molecular association, regulation cell growth, induced; cell differentiation, induced; transcription, induced; transcription, inhibited FOG1(INDUCES) 16107690; 26680303; 35580337 10 0 0 -IRF1 IRF1 Transcription factor; Tumor suppressor P10914 3659 5q31.1 human K95-ub 31914113 LPDIEEVkDQSRNKG IRF protein degradation; molecular association, regulation DNA(DISRUPTS) 23134341 1 2 0 -MYB Myb DNA-binding; Oncoprotein; Transcription factor P10242 4602 6q23.3 human K485-ac 458943 EIKYGPLkMLPQTPS Cmyb_C molecular association, regulation transcription, induced DNA(INDUCES) 10656693 1 0 0 -MAP2K1 MEK1 EC 2.7.12.2; KINASE; Kinase, protein; Protein kinase, STE; Protein kinase, dual-specificity (non-receptor) Q02750 5604 15q22.31 human T386-p 448288 IGLNQPStPTHAAGV molecular association, regulation; intracellular localization ERK2(INDUCES) 10567369; 18760948 5 6 57 nuclear translocation -Irs2 IRS2 Adaptor/scaffold; Motility/polarity/chemotaxis P81122 384783 8 A1.1|8 5.35 cM mouse Y814-p 454963 CSGDNDQyVLMSSPV molecular association, regulation; phosphorylation signaling pathway regulation PIK3R1(INDUCES) 24811175 1 29 692 promotes GSK3B phosphorylation, regulates aerobic glycolysis -YY1 YY1 C2H2-type zinc finger protein; Cell development/differentiation; Transcription factor P25490 7528 14q32.2 human Y254-p 464367 SPPDYSEyMTGKKLP transcription, inhibited 29807053 2 1 1 -Ctnnb1 CTNNB1 Actin-binding; Cell adhesion; Motility/polarity/chemotaxis; Nuclear receptor co-regulator; Oncoprotein; Transcription factor Q02248 12387 9 F4|9 72.19 cM mouse T120-p 6406005 QFDAAHPtNVQRLAE intracellular localization transcription, inhibited; signaling pathway regulation 31662443 6 0 0 GSK3B/B-Catenin/TCF-21 pathway -STK38L NDR2 EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, AGC; Protein kinase, Ser/Thr (non-receptor) Q9Y2H1 23012 12p11.23 human S282-p 460298 NRRQLAYsTVGTPDY Pkinase molecular association, regulation; enzymatic activity, induced cell growth, altered MST1(INDUCES); MOB1A(INDUCES); CCND1(INDUCES) 15037617; 16314523; 16488889; 23897809 4 1 10 -GLI1 GLI1 C2H2-type zinc finger protein; Oncoprotein; Transcription factor P08151 2735 12q13.3 human K518-ac 31077501 PIGTRGLkLPSLSHT transcription, inhibited 28716052 2 0 0 -Kirrel1 KIRREL Cell adhesion; Membrane protein, integral Q80W68 170643 3|3 F1 mouse Y637-p 463751 MKDPTNGyYNVRAHE molecular association, regulation cytoskeletal reorganization GRB2(INDUCES) 17923684; 34391780 3 12 84 induce podocyte repair -CCKBR CCKBR GPCR, family 1; Membrane protein, integral; Membrane protein, multi-pass; Receptor, GPCR P32239 887 11p15.4 human S434-p 6057803 TPSIASLsRLSYTTI molecular association, regulation RGS2(INDUCES) 19064631 1 1 0 -Phb1 PHB Apoptosis; Cell cycle regulation; Chaperone; Mitochondrial; Motility/polarity/chemotaxis; Nuclear receptor co-regulator; Oncoprotein; Transcription, coactivator/corepressor P67778 18673 11 59.01 cM|11 D mouse T258-p 11139253 LSRSRNItYLPAGQS molecular association, regulation carcinogenesis, induced; cell motility, induced RAF1(INDUCES) 22388104; 32859869 6 0 1 -EGFR EGFR EC 2.7.10.1; KINASE; Kinase, protein; Membrane protein, integral; Oncoprotein; Protein kinase, TK; Protein kinase, tyrosine (receptor) P00533 1956 7p11.2 human K1061-ub 27187816 GLQSCPIkEDSFLQR protein stabilization 32669362 1 4 0 SMURF2-UBE2D1 protein?protein interaction affects mutant EGFR levels -Ptk2 FAK EC 2.7.10.2; KINASE; Kinase, protein; Protein kinase, TK; Protein kinase, tyrosine (non-receptor) P34152 14083 15 D3|15 33.94 cM mouse Y861-p 447965 PTGNQHIyQPVGKPD phosphorylation carcinogenesis, induced; apoptosis, inhibited; cytoskeletal reorganization 17289681; 33730293 75 21 307 regulates tumor growth and blood vessel density; inhibits necrosis; Y861 phosphorylation is necessary for cell survival after osmotic stress. -HTT Huntingtin Cytoskeletal P42858 3064 4p16.3 human T3-p 10206804 _____MAtLEKLMKA protein stabilization; molecular association, regulation; protein conformation Huntingtin(INDUCES) 19710014; 28334491; 29162692; 30185623; 33256402 13 4 0 regulation of Huntingtin interaction and aggregation in lipid system -PTEN PTEN Carbohydrate Metabolism - inositol phosphate; EC 3.1.3.16; EC 3.1.3.48; EC 3.1.3.67; Motility/polarity/chemotaxis; Nuclear receptor co-regulator; PHOSPHATASE; Phosphatase, lipid; Tumor suppressor P60484 5728 10q23.31 human Y138-p 4000968 TGVMICAyLLHRGKF phosphorylation transcription, inhibited; signaling pathway regulation 31461649 3 0 0 induces NKAP dephosphorylation and suppresses RELA phosphorylation, regulates PTEN/NKAP/NF-KB/PDHK1 signaling -CLIP1 Restin iso3 Cytoskeletal P30622-2 6249 12q24.31 human T287-p 483203 KIGFPSTtPAKAKAN protein stabilization; intracellular localization cell cycle regulation; carcinogenesis, induced; apoptosis, inhibited; transcription, altered 23661607 3 6 3 induce AR stabilization and nuclear translocation/accumulation -CERK CERK EC 2.7.1.138; Kinase, lipid; Lipid Metabolism - sphingolipid Q8TCT0 64781 22q13.31 human S340-p 11485302 PAQHTVGsPRDRKPC protein stabilization 19899769 2 1 0 -FOXM1 FOXM1 DNA-binding; Transcription factor Q08050 2305 12p13.33 human K614-ac 57807001 PISSTPSkSVLPRTP activity, induced; protein stabilization; molecular association, regulation; phosphorylation carcinogenesis, induced; cell growth, induced; transcription, induced DNA(NOT_REPORTED) 27542221 1 1 0 -ARL8B ARL8B G protein, monomeric; G protein, monomeric, ARF Q9NVJ2 55207 3p26.1 human K141-ub 3934083 LPNALDEkQLIEKMN Arf protein degradation signaling pathway regulation 27808481 1 12 96 regulation of EGF-EGFR endocytic trafficking -ADD1 ADD1 Cytoskeletal; Motility/polarity/chemotaxis P35611 118 4p16.3 human S716-p 449828 GSPGKSPsKKKKKFR molecular association, regulation; intracellular localization cytoskeletal reorganization KPNA1(DISRUPTS) 21736685; 9679146 5 1 0 -STIM1 STIM1 Calcium-binding; Endoplasmic reticulum; Membrane protein, integral Q13586 6786 11p15.4 human Y361-p 25755095 THEVEVQyYNIKKQN SOAR molecular association, regulation; intracellular localization ORAI1(INDUCES) 28218251 2 0 1 Store operated calcium entry, increased vascular permeability -GRK2 GRK2 EC 2.7.11.15; KINASE; Kinase, protein; Protein kinase, AGC; Protein kinase, Ser/Thr (non-receptor) P21146 282682 cow Y13-p 456872 AVLADVSyLMAMEKS enzymatic activity, induced 18463167 5 0 0 -Nkx2-5 NKX2-5 DNA-binding P42582 18091 17 A3.3|17 13.6 cM mouse K182-ac 62518200 KLTSTQVkIWFQNRR Homeodomain molecular association, regulation transcription, induced TBX5(INDUCES); SRF(INDUCES) 27819261 1 1 0 deacetylation inhibits interactions -Tsc2 TSC2 Cell cycle regulation; GAP; GAP, misc.; Nuclear receptor co-regulator; Tumor suppressor P49816 24855 10q12 rat Y1573-p 448502 NEHGSYRyTEFLTGL Rap_GAP activity, induced; molecular association, regulation cell growth, altered TSC1(INDUCES) 11290735 2 0 1 -TGFBR1 TGFBR1 EC 2.7.11.30; KINASE; Kinase, protein; Membrane protein, integral; Protein kinase, Ser/Thr (receptor); Protein kinase, TKL; Receptor, misc. P36897 7046 9q22.33 human S172-p 4331006 SLDRPFIsEGTTLKD cell growth, altered 8576253 1 0 0 -PPARG PPAR-gamma iso2 DNA-binding; Nuclear receptor; Transcription factor P37231-2 5468 3p25.2 human K240-ac 25780500 ARAILTGkTTDKSPF transcription, induced 28416226 4 1 0 -Mip AQP0 Channel, misc.; Membrane protein, integral; Membrane protein, multi-pass; Transporter, aquaporin family P09011 25480 7q11 rat S243-p 451791 KGARPSDsNGQPEGT molecular association, regulation 22194645 2 0 0 No differences in the interaction with filensin between the AQP0 COOH-terminal peptide and its pseudophosphorylated proteins -CD274 PD-L1 Membrane protein, integral Q9NZQ7 29126 9p24.1 human T180-p 63237406 QVLSGKTtTTNSKRE C2-set_2 protein degradation; ubiquitination 27572267 1 0 0 -CTCF CTCF C2H2-type zinc finger protein; Transcription factor; Tumor suppressor P49711 10664 16q22.1 human K20-ac 3979891 SETFIKGkERKTYQR cell differentiation, induced; transcription, induced 36117192 1 0 4 differentiation of embryoid bodies, regulates genes associated with early cardiac mesoderm differentiation, facilitates enhancer-promoter interactions -FGFR1 FGFR1 EC 2.7.10.1; KINASE; Kinase, protein; Membrane protein, integral; Oncoprotein; Protein kinase, TK; Protein kinase, tyrosine (receptor) P11362 2260 8p11.23 human Y677-p 447920 EALFDRIyTHQSDVW PK_Tyr_Ser-Thr molecular association, regulation STAT3(INDUCES) 20388777 2 0 0 -ERCC2 ERCC2 EC 3.6.4.12; Helicase P18074 2068 19q13.32 human T425-p 1878257800 IEPFDDRtPTIANPI intracellular localization cell cycle regulation 35977011 1 1 0 regulates Eg5 localization -HNRNPK hnRNP K RNA splicing; RNA-binding; Spliceosome P61978 3190 9q21.32 human S216-p 450148 ILDLISEsPIKGRAQ activity, induced; molecular association, regulation; intracellular localization transcription, altered TDP-43(INDUCES) 11259409; 25410660 5 71 5 -PES1 PES1 Nucleolus; RNA-binding; Translation O00541 23481 22q12.2 human K517-sm 55435545 RVMAGTLkLEDKQRL protein stabilization; molecular association, regulation; ubiquitination cell cycle regulation; carcinogenesis, induced; cell growth, induced; transcription, induced; signaling pathway regulation TRIM23(DISRUPTS) 27409667 1 3 0 inhibits ubiquitination, induces estrogen signaling pathway -NPR1 ANPA EC 4.6.1.2; Guanylyl cyclase; KINASE; Kinase, protein; Lyase; Membrane protein, integral; Nucleotide Metabolism - purine; Protein kinase, RGC; Protein kinase, dual-specificity (receptor); Receptor, misc. P16066 4881 1q21.3 human S519-p 14364503 WEDVEPSsLERHLRS enzymatic activity, induced 28416574 2 2 0 -TRIM28 TIF1B EC 6.3.2.-; KINASE; Kinase, protein; Ligase; Nuclear receptor co-regulator; Protein kinase, atypical; SUMO LIGASE; SUMO ligase; Transcription, coactivator/corepressor; UBIQUITIN LIGASE; Ubiquitin conjugating system; Ubiquitin ligase Q13263 10155 19q13.43 human K554-sm 2798310 LAGMAIVkEEETEAA molecular association, regulation; acetylation; methylation cell growth, induced; transcription, inhibited CHD-3(INDUCES) 17079232; 17942393; 21642969; 31391303 5 2 0 loss of TF1B sumoylation induces dsRNA-activated IFN-mediated defenses that rely on RIG-I, MAVS, TBK1, and JAK1 transcription, SUMOylated TIF1B Is required to support efficient virus replication -ENDOG ENDOG Apoptosis; Deoxyribonuclease; EC 3.1.30.-; Mitochondrial; Ribonuclease Q14249 2021 9q34.11 human T128-p 1871762501 VHAYHRAtNADYRGS Endonuclease_NS protein degradation; molecular association, regulation autophagy, induced; signaling pathway regulation 14-3-3 gamma(INDUCES) 33473107 1 0 0 binding to 14-3-3 gamma inhibits 14-3-3 gamma binding to TSC2 and Vps34, inhibits mTOR signaling pathway, induces SQSTM1 degradation -Grk2 GRK2 EC 2.7.11.15; KINASE; Kinase, protein; Protein kinase, AGC; Protein kinase, Ser/Thr (non-receptor) Q99MK8 110355 19 A|19 3.98 cM mouse Y92-p 456873 FYEEIKKyEKLETEE RGS cell motility, altered 18369319 5 0 0 -CD6 CD6 Cell surface; Membrane protein, integral P30203 923 11q12.2 human Y629-p 450238 STSSGEWyQNFQPPP activity, induced; molecular association, regulation SLP76(INDUCES); GRB2(INDUCES); GADS(INDUCES); TSAd(INDUCES) 27896837; 28289074 3 1 0 -MAP3K20 ZAK EC 2.7.11.25; KINASE; Kinase, protein; Protein kinase, Ser/Thr (non-receptor); Protein kinase, TKL Q9NYL2 51776 2q31.1 human T161-p 455377 ASRFHNHtTHMSLVG PK_Tyr_Ser-Thr enzymatic activity, induced 15342622 1 0 0 -Nlgn1 NLGN1 Membrane protein, integral Q62765 rat Y782-p 1008111 RTACPPDyTLAMRRS molecular association, regulation signaling pathway regulation PSD-95(INDUCES); gephyrin(DISRUPTS) 23770246 3 1 0 Binding to gephyrin induces inhibitory synapses and binding to PSD-95 induces excitatory synapses. -RXRA RXRA DNA-binding; Motility/polarity/chemotaxis; Nuclear receptor P19793 6256 9q34.2 human S27-p 3188103 TSPTGRGsMAAPSLH Nuc_recep-AF1 activity, inhibited transcription, altered 11162439 1 0 0 -FOXO1 FOXO1A DNA-binding; Nuclear receptor co-regulator; Oncoprotein; Transcription factor Q12778 2308 13q14.11 human K294-ac 15625100 SPGSQFSkWPASPGS intracellular localization; phosphorylation 20519497 1 0 0 -VDR VDR DNA-binding; Nuclear receptor; Transcription factor P11473 7421 12q13.11 human S208-p 456982 SFSNLDLsEEDSDDP molecular association, regulation transcription, induced; transcription, altered MED1(INDUCES) 17368182; 8622969 5 0 0 -Tgfbr1 TGFBR1 EC 2.7.11.30; KINASE; Kinase, protein; Membrane protein, integral; Protein kinase, Ser/Thr (receptor); Protein kinase, TKL; Receptor, misc. Q64729 21812 4 B1|4 26.02 cM mouse Y182-p 7791190 TTLKDLIyDMTTSGS TGF_beta_GS molecular association, regulation carcinogenesis, induced; cell motility, induced; transcription, induced; signaling pathway regulation TGFBR2(INDUCES) 35538070 2 1 2 induces the TGF?/Smad2/PTHLH pathway -YAP1 YAP1 Oncoprotein; Transcription, coactivator/corepressor P46937 10413 11q22.1 human S138-p 485036 SLQLGAVsPGTLTPT molecular association, regulation; intracellular localization cell cycle regulation; apoptosis, inhibited TEAD4(DISRUPTS) 24812269; 26933062 4 30 79 mitotic shift, important for proper mitosis and cytokinesis -NFKBIA IkB-alpha DNA-binding; Inhibitor P25963 4792 14q13.2 human T299-p 456335 ESEFTEFtEDELPYD protein degradation 8657113 2 0 0 S283/T291/T299A triple mutant showed increased IkB-alpha stability. -CFTR CFTR Channel, chloride; EC 3.6.3.49; Hydrolase; Membrane protein, integral; Membrane protein, multi-pass; Transporter; Transporter, ABC family P13569 1080 7q31.2 human S813-p 449983 DIYSRRLsQETGLEI CFTR_R activity, induced; molecular association, regulation; enzymatic activity, inhibited; protein conformation CFTR(INDUCES) 11053017; 14602047; 1716180; 32102849; 36695813 13 6 0 -FOXO1 FOXO1A DNA-binding; Nuclear receptor co-regulator; Oncoprotein; Transcription factor Q12778 2308 13q14.11 human T649-p 35486505 PHSVKTTtHSWVSG_ intracellular localization transcription, induced 25065674 1 0 0 -Nr3c1 GR DNA-binding; Mitochondrial; Nuclear receptor; Transcription factor P06537 14815 18 B3|18 21.09 cM mouse S243-p 451796 LIDENLLsPLAGEDD GCR activity, inhibited transcription, induced; transcription, inhibited; signaling pathway regulation 21994940; 25477995; 30738183 39 9 1 -CDK1 CDK1 Cell cycle regulation; EC 2.7.11.22; EC 2.7.11.23; KINASE; Kinase, protein; Motility/polarity/chemotaxis; Protein kinase, CMGC; Protein kinase, Ser/Thr (non-receptor) P06493 983 10q21.2 human S39-p 455465 MKKIRLEsEEEGVPS Pkinase cell cycle regulation; DNA repair, induced 15788687; 36189922 3 12 26 -Itch ITCH EC 6.3.2.-; EC 6.3.2.19; Ligase; UBIQUITIN LIGASE; Ubiquitin conjugating system; Ubiquitin ligase Q8C863 16396 2 H1|2 76.94 cM mouse S232-p 459623 RPASVNGsPSTNSDS activity, induced; protein stabilization; protein conformation 16446428 1 0 0 -NGFR NGFR Membrane protein, integral; Receptor, misc. P08138 4804 17q21.33 human S425-p 41389903 CSESTATsPV_____ molecular association, regulation carcinogenesis, inhibited CLIM1(DISRUPTS) 26119933 1 1 0 NGFR mediated glioma invasion -USF2 USF2 DNA-binding; Transcription factor Q15853 7392 19q13.12 human S222-p 9285181 APRTHPYsPKIDGTR protein stabilization carcinogenesis, induced; cell motility, induced; cell growth, induced; transcription, induced 31013770 1 8 11 Increase in USF2 mRNA expresssion was observed in MDA-MB-231 CDK5 knockout cells -IFNAR2 IFNAR2 Membrane protein, integral; Receptor, cytokine P48551 3455 21q22.11 human Y306-p 26416401 MDMVEVIyINRKKKV molecular association, regulation transcription, induced; signaling pathway regulation STAT2(DISRUPTS) 34813358 2 0 0 induces STAT phosphorylation and signaling -PPP5C PPP5C EC 3.1.3.16; PHOSPHATASE; Protein phosphatase, Ser/Thr (non-receptor) P53041 5536 19q13.32 human K185-ub 21182254 GPKLEDGkVTISFMK PPP5 protein degradation; ubiquitination 29141220 1 5 0 -Dpysl2 CRMP-2 Microtubule-binding; Motility/polarity/chemotaxis P47942 25416 15p12 rat T509-p 448083 PVCEVSVtPKTVTPA molecular association, regulation CRMP-4(DISRUPTS); CRMP-1(DISRUPTS); ROCK2(DISRUPTS); SLC25A4(DISRUPTS) 18220421; 24036111 16 63 34 -RAB29 RAB29 G protein; G protein, monomeric; G protein, monomeric, Rab O14966 8934 1q32.1 human T71-p 406855300 IAGQERFtSMTRLYY Ras activity, inhibited 29212815 3 0 0 Rab29 phosphorylation may decrease its ability to activate LRRK2 -Oprk1 KOR-1 GPCR, family 1; Membrane protein, integral; Membrane protein, multi-pass; Receptor, GPCR P33534 18387 1 A1|1 1.89 cM mouse T363-p 52467202 STNRVRNtVQDPASM receptor internalization, induced; intracellular localization; phosphorylation 26635353; 35652052 3 1 0 -CAP1 CAP1 Actin-binding; Cytoskeletal Q01518 10487 1p34.2 human S308-p 485063 SAPKPQTsPSPKRAT activity, induced carcinogenesis, induced; cell motility, induced; cell growth, induced; cell adhesion, induced; apoptosis, inhibited; transcription, induced; cytoskeletal reorganization 30123351; 30894654; 34636991 4 46 29 -Ddx41 DDX41 EC 3.6.4.13; Helicase; RNA splicing; RNA-binding; Spliceosome Q91VN6 72935 13|13 B1 mouse K9-ub 27992511 EDSEPERkRARADEA protein degradation transcription, inhibited 23222971 1 0 0 -MAPK7 ERK5 EC 2.7.11.24; KINASE; Kinase, protein; Protein kinase, CMGC; Protein kinase, Ser/Thr (non-receptor) Q13164 5598 17p11.2 human K184-ub 63128906 QVIHRDLkPSNLLVN Pkinase molecular association, regulation; enzymatic activity, induced transcription, induced Fos(INDUCES) 28131816 1 2 0 -TLR8 TLR8 Membrane protein, integral; Receptor, misc. Q9NR97 51311 Xp22.2 human Y1030-p 953800 LTENDSRyNNMYVDS TIR molecular association, regulation signaling pathway regulation PIK3R1(INDUCES) 17868034 1 0 0 inhibits IL-8 synthesis -RELA NFkB-p65 DNA-binding; Nuclear receptor co-regulator; Transcription factor Q04206 5970 11q13.1 human K195-ub 10304900 APNTAELkICRVNRN RHD_dimer protein degradation; activity, inhibited transcription, altered 19706600 2 2 0 TNF alpha - induced RelA polyubiquitination and degradation -Grik2 GluR6 Channel, calcium; Channel, ligand-gated; Membrane protein, integral; Membrane protein, multi-pass P42260 54257 20q13 rat S868-p 478417 MVEELRMsLKCQRRL receptor recycling, inhibited; sumoylation; molecular association, regulation exocytosis, inhibited; endocytosis, induced 14-3-3 theta(INDUCES) 22089239; 23861400; 28636947 7 0 0 increases sumoylation; recycled more ef?ciently to the cell surface -TPX2 TPX2 Cell cycle regulation; Microtubule-binding Q9ULW0 22974 20q11.21 human S322-p 31890658 RTFDETVsTYVPLAQ intracellular localization KPNB1(INDUCES) 29276125 1 1 0 accumulation of TPX2 at the prophase centrosome -TRIP13 TRIP13 Nuclear receptor co-regulator; Transcription, coactivator/corepressor Q15645 9319 5p15.33 human Y56-p 450833 HNIVFGDyTWTEFDE protein stabilization DNA repair, induced; carcinogenesis, induced; cell growth, induced; signaling pathway regulation 32860853; 34111559 2 1 4 -KCND3 Kv4.3 Channel, potassium; Membrane protein, integral; Membrane protein, multi-pass Q9UK17 3752 1p13.2 human Y108-p 23045802 GKLHYPRyECISAYD BTB_2 activity, induced 22198508 1 0 0 positive regulation of Kv4.3 channel and cellular electrical activity -MC4R MC4R GPCR, family 1; Membrane protein, integral; Membrane protein, multi-pass; Receptor, GPCR P32245 4160 18q21.32 human T312-p 449101 RSQELRKtFKEIICC receptor recycling, inhibited; intracellular localization; receptor internalization, altered; activity, inhibited 12639913; 22544740 2 0 0 retains MC4R in the endosomal compartment -TP53 p53 Activator; DNA-binding; Motility/polarity/chemotaxis; Nuclear receptor co-regulator; Transcription factor; Tumor suppressor P04637 7157 17p13.1 human K139-ub 486295 KMFCQLAkTCPVQLW P53 protein degradation; intracellular localization 17371868; 31492752 2 1 0 -Ccnd2 CCND2 Cell cycle regulation; Motility/polarity/chemotaxis P30280 12444 6 F3|6 61.92 cM mouse K270-ub 1872854200 EQHNAGSkSVEDPDQ Cyclin_C protein degradation cell cycle regulation; carcinogenesis, inhibited 22323446 1 0 0 -APLP2 APLP2 Cell surface; DNA-binding; Membrane protein, integral; Receptor, misc. Q06481 334 11q24.3 human T736-p 451599 VEVDPMLtPEERHLN APP_amyloid molecular association, regulation APBA2(INDUCES); Fe65(INDUCES) 11517218; 14970211 3 2 1 Phosphorylation of APP and APLP2 was enhanced by osmotic stress, binding to ABPA2, and JNK (in vitro). -Cry2 CRY2 DNA-binding; Lyase Q9R194 12953 2|2 E1 mouse K474-ub 12369753 NAPESVQkAAKCIIG FAD_binding_7 protein degradation; intracellular localization 23452856 1 4 1 -FLI1 FLI1 DNA-binding; Oncoprotein; Transcription factor Q01543 2313 11q24.3 human T312-p 6406002 TNGEFKMtDPDEVAR Ets protein degradation; molecular association, regulation; acetylation transcription, induced; transcription, inhibited; transcription, altered p300(DISRUPTS) DNA(INDUCES) 19158279; 21321929; 24058639; 25707716 6 0 0 inhibited transcription of CDH5, PECAM1, PDGFB and MMP9 genes, impaired leaky vessels -Bad BAD Apoptosis Q61337 12015 19|19 A mouse S26-p 27530804 KSDPGIRsLGSDAGG molecular association, regulation; intracellular localization; activity, inhibited; phosphorylation apoptosis, inhibited 14-3-3 beta(INDUCES); Bcl-xL(DISRUPTS) 23332762 1 1 0 induces phosphorylation at S112, S136 and S155 -Scn5a SCN5A Channel, sodium; Membrane protein, integral; Membrane protein, multi-pass Q9JJV9 20271 9 F3|9 71.33 cM mouse S1988-p 235474402 DSVTRATsDNLPVRA activity, induced; molecular association, regulation FGF13(DISRUPTS); Calmodulin(DISRUPTS) 28882890 2 2 0 impairs FGF13-dependent regulation of NaV1.5 channel inactivation -Ntrk2 TrkB EC 2.7.10.1; KINASE; Kinase, protein; Membrane protein, integral; Protein kinase, TK; Protein kinase, tyrosine (receptor) P15209 18212 13 B1|13 31.2 cM mouse Y515-p 448813 PVIENPQyFGITNSQ receptor internalization, altered; phosphorylation; enzymatic activity, induced neural plasticity; cell growth, inhibited; cell differentiation, induced; signaling pathway regulation; cell growth, altered 11877382; 14581459; 21562256; 31914388 23 2 40 MEK/ERK1/1 pathway -INSR INSR EC 2.7.10.1; KINASE; Kinase, protein; Membrane protein, integral; Protein kinase, TK; Protein kinase, tyrosine (receptor) P06213 3643 19p13.2 human Y1190-p 447682 DIYETDYyRKGGKGL PK_Tyr_Ser-Thr molecular association, regulation; receptor internalization, altered; phosphorylation; enzymatic activity, induced transcription, altered IRS2(INDUCES); PTP1B(INDUCES) 10852715; 11850117; 1658004; 22081023; 8024702; 8999839; 9195949 46 14 107 prolactin transcription -KDM1A LSD1 DEMETHYLASE; Demethylase; EC 1.-.-.-; Nuclear receptor co-regulator; Oxidoreductase; Transcription factor O60341 23028 1p36.12 human K277-ub 1881258600 IKPLPTKkTGKVIII protein degradation; molecular association, regulation carcinogenesis, induced; transcription, altered RCOR1(DISRUPTS); CDC6(INDUCES) 34050636 1 1 0 disrupts LSD1 association from RCOR1/HDACs complex -ATG5 ATG5 Apoptosis; Autophagy; Ubiquitin conjugating system Q9H1Y0 9474 6q21 human T101-p 23084709 SALPWNItVHFKSFP APG5 protein stabilization; molecular association, regulation; ubiquitination carcinogenesis, induced; autophagy, induced; cell growth, induced; apoptosis, inhibited ATG16L1(INDUCES); USP13(INDUCES) 32186433; 36528756 2 1 1 induces deubiquitination; inhibits ubiquitination -RELA NFkB-p65 DNA-binding; Nuclear receptor co-regulator; Transcription factor Q04206 5970 11q13.1 human K218-ac 459095 EIFLLCDkVQKEDIE RHD_dimer intracellular localization carcinogenesis, induced; transcription, induced 19345327; 27007123 7 0 0 induces JCV activation -NFKB1 NFkB-p105 DNA-binding; Transcription factor P19838 4790 4q24 human K441-ac 465127 TMDTESKkDPEGCDK molecular association, regulation; intracellular localization DNA(INDUCES) 11739381 1 1 0 nuclear translocation -RARA RARA DNA-binding; Nuclear receptor; Oncoprotein; Transcription factor P10276 5914 17q21.2 human K166-sm 10902802 RNDRNKKkKEVPKPE transcription, induced 19850744 1 0 0 -IKBKG IKKG Adaptor/scaffold; Protein kinase, regulatory subunit Q9Y6K9 8517 Xq28 human K399-ub 486357 PPDFCCPkCQYQAPD zf_C2H2_10 enzymatic activity, induced transcription, induced; signaling pathway regulation 14695475; 15125833; 17363905; 17728323; 23871670 5 0 0 K-R mutants cause embryonic lethality, complemented by TNFR1 loss, regulates NF-kB activation and NOD2 signaling in response to innate immune agonists -Gphn gephyrin Adaptor/scaffold; EC 2.10.1.1; EC 2.7.7.75 Q03555 64845 6q24 rat K161-sm 1876579502 IINLPGSkKGSQECF MoCF_biosynth molecular association, regulation gephyrin(DISRUPTS) 35307349 1 0 0 -Kcnj5 GIRK4 Channel, potassium; Membrane protein, integral; Membrane protein, multi-pass P48548 29713 8q21 rat Y53-p 3146603 GKKPRQRyMEKTGKC activity, inhibited 10833508 1 0 0 -RNF157 RNF157 UBIQUITIN LIGASE; Ubiquitin conjugating system; Ubiquitin ligase Q96PX1 114804 17q25.1 human S662-p 5202125 QRRRLSSsSLEDSET protein degradation; molecular association, regulation; ubiquitination CDH1(INDUCES) 28655764 1 2 2 -IL27RA IL27RA Membrane protein, integral Q6UWB1 9466 19p13.12 human Y613-p 478855 TAPLDSGyEKHFLPT molecular association, regulation transcription, altered STAT1(INDUCES) 33871355 1 1 2 induces STAT1 phosphorylation -NUP98 NUP98 iso2 Motility/polarity/chemotaxis; Nucleoporin P52948-2 4928 11p15.4 human S822-p 3150833 TSRCLIKsPDRLADI Nucleoporin2 intracellular localization 21335236 1 28 18 as multiple sites (13PM) mutant -EGLN2 EGLN2 EC 1.14.11.29; Oxidoreductase Q96KS0 112398 19q13.2 human T405-p 50777944 VPVSQPPtPT_____ protein degradation; molecular association, regulation; ubiquitination FBXW7(INDUCES) 28036276 1 3 0 -PRKCA PKCA EC 2.7.11.13; KINASE; Kinase, protein; Oncoprotein; Protein kinase, AGC; Protein kinase, Ser/Thr (non-receptor) P04409 282001 cow T494-p 449889 EHMMDGVtTRTFCGT Pkinase enzymatic activity, induced 8349635 2 1 4 -NTRK2 TrkB EC 2.7.10.1; KINASE; Kinase, protein; Membrane protein, integral; Protein kinase, TK; Protein kinase, tyrosine (receptor) Q16620 4915 9q21.33 human Y706-p 448811 RDVYSTDyYRVGGHT PK_Tyr_Ser-Thr activity, induced; molecular association, regulation; phosphorylation carcinogenesis, induced; signaling pathway regulation PTP1B(INDUCES) 15494731; 25288805; 33820494 15 0 49 GKAP1-NTRK2 activity induced -WRN WRN Cell cycle regulation; DNA repair, damage; DNA-binding; EC 3.6.4.12; Helicase; Nucleolus Q14191 7486 8p12 human K366-ac 14512102 GEDVLGNkVERKEDG protein stabilization; ubiquitination 20428248 1 1 0 inhibits ubiquitination -IGF1R IGF1R EC 2.7.10.1; KINASE; Kinase, protein; Membrane protein, integral; Protein kinase, TK; Protein kinase, tyrosine (receptor) P08069 3480 15q26.3 human K1150-sm 12723516 VAEDFTVkIGDFGMT PK_Tyr_Ser-Thr intracellular localization transcription, induced DNA(INDUCES) 20145208 1 0 0 enhances nuclear localization and accumulation of IGF1-R, binding to DNA enhancer regions and inducing transcription. -EDNRA EDNRA GPCR, family 1; Membrane protein, integral; Membrane protein, multi-pass; Motility/polarity/chemotaxis; Receptor, GPCR P25101 1909 4q31.22-q31.23 human T417-p 2911709 HDQNNHNtDRSSHKD receptor desensitization, induced 24064210 1 1 0 Lack of S397, T403 and S404 influences desensitization to a greater extent compared than S391, S393, and T396 -BBC3 PUMA Apoptosis; Mitochondrial Q9BXH1 27113 19q13.32 human Y172-p 29674705 PSPWRVLyNLIMGLL PUMA protein degradation; intracellular localization cell growth, induced; apoptosis, inhibited 24236056 1 0 1 -Polr2a POLR2A EC 2.7.7.48; EC 2.7.7.6; Nucleotide Metabolism - purine; Nucleotide Metabolism - pyrimidine; Transcription initiation complex; Transferase P08775 20020 11 B3|11 42.86 cM mouse K1908-ub 2134721 VYTPTSPkYSPTSPT RNA_pol_Rpb1_R protein degradation 17526739 1 1 0 -CDK16 CDK16 Cell cycle regulation; EC 2.7.11.22; KINASE; Kinase, protein; Motility/polarity/chemotaxis; Protein kinase, CMGC; Protein kinase, Ser/Thr (non-receptor) Q00536 5127 Xp11.3 human S119-p 453450 EDINKRLsLPADIRL molecular association, regulation cytoskeletal reorganization 14-3-3 beta(INDUCES); 14-3-3 zeta(INDUCES); 14-3-3 gamma(INDUCES) 12154078 4 60 0 -HNRNPK hnRNP K RNA splicing; RNA-binding; Spliceosome P61978 3190 9q21.32 human S302-p 457408 GRGGRGGsRARNLPL molecular association, regulation; phosphorylation apoptosis, inhibited PKCD(INDUCES); PKCD(DISRUPTS) 10329716; 25104022 4 0 0 methylation of R296 and R299 suppress S302 phosphorylation, R296/R299 methylation reduces apoptosis in U2OS-K- 2RK cells after DNA damage -NOS3 eNOS Amino Acid Metabolism - arginine and proline; EC 1.14.13.39; Oxidoreductase P29474 4846 7q36.1 human T495-p 447885 TGITRKKtFKEVANA molecular association, regulation; intracellular localization; enzymatic activity, inhibited Calmodulin(DISRUPTS) 11397791; 12574113; 21757745; 33539947; 33578126; 35074481; 35617030; 35884891 82 2 1 -H1-2 H1C DNA-binding P16403 3006 6p22.2 human K34-m1 50094511 KAGGTPRkASGPPVS molecular association, regulation 28392790 1 1 1 increased interaction with NS2 -PTEN PTEN Carbohydrate Metabolism - inositol phosphate; EC 3.1.3.16; EC 3.1.3.48; EC 3.1.3.67; Motility/polarity/chemotaxis; Nuclear receptor co-regulator; PHOSPHATASE; Phosphatase, lipid; Tumor suppressor P60484 5728 10q23.31 human Y155-p 4000973 AQEALDFyGEVRTRD protein stabilization; molecular association, regulation WWP2(DISRUPTS) 21532586; 22891331 3 1 0 -ESPL1 separase EC 3.4.22.49; Protease Q14674 9700 12q13.13 human S1153-p 40666500 CDCSLCAsPVLTAVC molecular association, regulation PIN1(INDUCES) 25921067 1 0 0 -RET Ret EC 2.7.10.1; KINASE; Kinase, protein; Membrane protein, integral; Oncoprotein; Protein kinase, TK; Protein kinase, tyrosine (receptor) P07949 5979 10q11.21 human Y981-p 450703 DNCSEEMyRLMLQCW PK_Tyr_Ser-Thr molecular association, regulation; enzymatic activity, induced Src(INDUCES) 11956105; 14766744 7 1 0 -Blnk BLNK Adaptor/scaffold Q9QUN3 17060 19 C3|19 34.26 cM mouse K38-ub 23303204 GIMDKIKkLKVKGPP molecular association, regulation; ubiquitination 14-3-3 beta(INDUCES) 22334673 1 0 0 Thr-152 phosphorylation induces BLNK ubiquitination at K37, K38, K42. -Ppp1r1a PPP1R1A Inhibitor; Protein phosphatase, regulatory subunit P19103 58977 7q36 rat T35-p 447759 QIRRRRPtPATLVLT DARPP-32 activity, inhibited; phosphorylation 21447388 14 4 0 induces PLB dephosphorylation -RELA NFkB-p65 DNA-binding; Nuclear receptor co-regulator; Transcription factor Q04206 5970 11q13.1 human K315-ac 1985901 TFKSIMKkSPFSGPT molecular association, regulation; intracellular localization carcinogenesis, induced; cell motility, induced; cell growth, induced; transcription, induced; transcription, inhibited; transcription, altered DNA(DISRUPTS) 18263619; 20064247; 23087373; 28167529; 31939185; 34626802 7 1 0 recruited to the IL-8 promoter -NDC80 HEC1 Cell cycle regulation O14777 10403 18p11.32 human T49-p 474512 KLSINKPtSERKVSL cell cycle regulation; cytoskeletal reorganization 17129782; 35878017 2 1 0 -POU5F1 Oct4 DNA-binding; Transcription factor Q01860 5460 6p21.33 human S236-p 6738001 ARKRKRTsIENRVRG Homeodomain molecular association, regulation transcription, inhibited DNA(DISRUPTS) 22474382 1 3 0 -STXBP5L STXBP5L Q9Y2K9 9515 3q13.33 human S812-p 34668140 TEENRENsYNRSRSS Lgl_C protein degradation 25002582 1 1 0 ; in a multiple residue S->D mutant -ATG9A ATG9A Autophagy; Membrane protein, integral; Membrane protein, multi-pass; Vesicle Q7Z3C6 79065 2q35 human S761-p 4722321 QSIPRSAsYPCAAPR molecular association, regulation autophagy, induced 14-3-3 zeta(INDUCES) 25266655 1 10 11 -HERC2 HERC2 EC 6.3.2.-; EC 6.3.2.19; Ligase; Mitochondrial; UBIQUITIN LIGASE; Ubiquitin conjugating system; Ubiquitin ligase O95714 8924 15q13.1 human T4827-p 12122400 DSFASDStQDYLTGH molecular association, regulation; ubiquitination RNF8(INDUCES) 20023648; 22508508 2 0 0 -NR1I2 PXR DNA-binding; Nuclear receptor O75469 8856 3q13.33 human S221-p 1868023601 QLRGEDGsVWNYKPP molecular association, regulation transcription, inhibited SMRT(INDUCES); SRC-1(DISRUPTS); N-CoR1(INDUCES); GRIP1(DISRUPTS); RKIP(DISRUPTS); RXRA(DISRUPTS) 32205367 1 1 0 -MYH9 MYH9 Actin-binding; Motility/polarity/chemotaxis; Motor P35579 4627 22q12.3 human Y1408-p 462335 HEEKVAAyDKLEKTK Myosin_tail_1 carcinogenesis, inhibited; cell motility, inhibited 31735331 1 20 916 upregulates EGFR expression -U2AF1 U2AF1 RNA processing; RNA splicing; RNA-binding; Spliceosome Q01081 7307 21q22.3 human S34-p 1868227100 CRHGDRCsRLHNKPT zf-CCCH phosphorylation carcinogenesis, inhibited; RNA splicing, altered; cell differentiation, induced; transcription, inhibited; signaling pathway regulation 31011167 1 0 0 inhibits phosphorylation of p38, ERK, IRAK1, IKK and p65, regulates innate immune signaling and NF-kB signaling -SQSTM1 SQSTM1 Autophagy; Nuclear receptor co-regulator; Ubiquitin conjugating system Q13501 8878 5q35.3 human S28-p 3195656 RRFSFCCsPEPEAEA PB1 protein degradation; molecular association, regulation; ubiquitination; intracellular localization carcinogenesis, induced; autophagy, induced; cell growth, induced; apoptosis, inhibited; transcription, induced TRIM21(DISRUPTS); SQSTM1(INDUCES); KEAP1(INDUCES) 31032410 1 10 7 inhibits ubiquitination, regulates Nrf2 localization -Rasd1 RASD1 G protein; G protein, monomeric; G protein, monomeric, RasD O35626 19416 11|11 B1.3 mouse S253-p 50402002 APFARRPsVHSDLMY activity, inhibited signaling pathway regulation 26358293 1 2 0 inhibits S-nitrosylation of RASD1, prevents NO-mediated iron uptake pathway via RASD1 (aka Dexras1) -PGRMC1 PGRMC1 Membrane protein, integral; Receptor, misc. O00264 10857 Xq24 human S57-p 452526 QPAASGDsDDDEPPP apoptosis, altered; cell growth, induced 18922159; 29069804 3 62 1 -RB1 Rb Nuclear receptor co-regulator; Oncoprotein; Transcription, coactivator/corepressor; Tumor suppressor P06400 5925 13q14.2 human S780-p 447978 STRPPTLsPIPHIPR Rb_C protein degradation; molecular association, regulation; activity, inhibited cell cycle regulation; carcinogenesis, induced; carcinogenesis, inhibited; cell growth, inhibited; transcription, induced; transcription, altered; cell growth, induced; apoptosis, inhibited; transcription, inhibited; cell growth, altered ID2(DISRUPTS); E2F1(DISRUPTS); E2F1(INDUCES) 11641415; 11746527; 14676836; 15028555; 15619620; 17478427; 19225156; 21880723; 22279936; 23429262; 24466208; 31615938; 33556114; 33767437; 33793628; 34158578; 34247189; 35437308; 35513564; 36372230; 9315635 98 17 128 -NPR1 ANPA EC 4.6.1.2; Guanylyl cyclase; KINASE; Kinase, protein; Lyase; Membrane protein, integral; Nucleotide Metabolism - purine; Protein kinase, RGC; Protein kinase, dual-specificity (receptor); Receptor, misc. P16066 4881 1q21.3 human T545-p 447516 SNYGSLLtTEGQFQV PK_Tyr_Ser-Thr activity, induced; enzymatic activity, induced 28416574; 9528788 3 2 0 -Myod1 MyoD DNA-binding; RNA splicing; Transcription factor P10085 17927 7 B3|7 30.03 cM mouse Y156-p 18755302 ILRNAIRyIEGLQAL HLH protein stabilization; molecular association, regulation transcription, altered FBXO32(DISRUPTS) 21454680 1 1 0 stimulates skeletal myogenesis -Scin SCIN Motility/polarity/chemotaxis Q60604 20259 12|12 B1 mouse K189-ac 1883618700 CNKYERLkASQVAIG cytoskeletal reorganization 37450577 1 1 0 -MEF2D MEF2D DNA-binding; Transcription factor Q14814 4209 1q22 human S180-p 449933 LTDPRLLsPQQPALQ transcription, induced 26660426 3 44 11 IEG genes during preBCR signaling -ATRIP ATRIP Cell cycle regulation; DNA repair, damage; DNA-binding Q8WXE1 84126 3p21.31 human S68-p 454388 EELDTLAsQALSQCP intracellular localization 15451423 1 0 0 -CAMK4 CAMK4 EC 2.7.11.17; KINASE; Kinase, protein; Protein kinase, CAMK; Protein kinase, Ser/Thr (non-receptor) Q16566 814 5q22.1 human S189-gl 7780008 KIADFGLsKIVEHQV Pkinase enzymatic activity, inhibited 19506079 1 1 0 reduced GlcNAcylation levels by 70% -Wnk4 WNK4 EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, Other; Protein kinase, Ser/Thr (non-receptor) Q80UE6 69847 11|11 D mouse K990-ub 40323311 APISEEGkPQLVGRF protein degradation 23576762 1 1 0 regulates electrolyte homeostasis and involved in Pseudohypoaldosteronism type II (PHAII) pathogenesis -Ahcyl2 AHCYL2 Amino Acid Metabolism - cysteine and methionine; EC 3.3.1.1; Hydrolase; Motility/polarity/chemotaxis; Other Amino Acids Metabolism - selenoamino acid Q68FL4 74340 6|6 A3.3 mouse S154-p 7172001 SRSISQSsTDSYSSA molecular association, regulation SLC4A4(INDUCES) 27382360 2 0 1 S149 and T172 are also involved in activation of SLCA4 -ARHGDIA RhoGDI alpha Apoptosis; Cell adhesion; Cell development/differentiation; G protein regulator, misc.; Motility/polarity/chemotaxis P52565 396 17q25.3 human K178-ac 3669184 ARGSYSIkSRFTDDD Rho_GDI molecular association, regulation cytoskeletal reorganization RHOA(DISRUPTS) 26719334 1 5 3 affects actin filament formation -Foxo3 FOXO3A Autophagy; DNA-binding; Oncoprotein; Transcription factor Q9WVH4 56484 10 B2|10 22.79 cM mouse S412-p 12084437 GLMQRGSsFPYTAKS apoptosis, inhibited; signaling pathway regulation 19942091 5 7 2 Akt-AMPK-Foxo3 signaling -KCNK18 KCNK18 Channel, ligand-gated; Channel, potassium; Membrane protein, integral; Membrane protein, multi-pass Q7Z418 338567 10q25.3 human S252-p 2712200 QAMERSNsCPELVLG intracellular localization; activity, inhibited transcription, inhibited 25202008; 30327410 8 0 1 -Ccnd1 CCND1 Activator; Cell cycle regulation; Nuclear receptor co-regulator; Oncoprotein P25322 12443 7 F5|7 88.92 cM mouse T286-p 447839 EEAGLACtPTDVRDV activity, induced; protein degradation; protein stabilization; molecular association, regulation; ubiquitination; intracellular localization cell cycle regulation; carcinogenesis, inhibited PIN1(INDUCES) 11124803; 11805292; 15735756; 17130121; 18606783; 35210557; 9136925; 9832503 35 5 1 -FUS hnRNP P2 DNA-binding; Nuclear receptor co-regulator; Oncoprotein; RNA splicing; RNA-binding; SUMO LIGASE P35637 2521 16p11.2 human S439-p 56654253 TCENMNFsWRNECNQ zf-RanBP molecular association, regulation translation, inhibited RNA(DISRUPTS) 35777956 1 2 0 -NOTCH1 Notch 1 Membrane protein, integral; Motility/polarity/chemotaxis; Oncoprotein; Receptor, misc.; Transcription factor P46531 4851 9q34.3 human S2523-p 467289 SPDQWSSsSPHSNVS protein degradation; receptor inactivation, altered 16880534 1 0 0 Alanine mutation of 4 serines (S2522/S2523/S2524/S2525) causes increased protein stability. -SMURF2 SMURF2 EC 6.3.2.-; EC 6.3.2.19; Ligase; UBIQUITIN LIGASE; Ubiquitin conjugating system; Ubiquitin ligase Q9HAU4 64750 17q23.3-q24.1 human R239-m2 56854402 RVRSQRHrNYMSRTH protein degradation 26126536 1 0 0 -PXN PXN iso2 Adaptor/scaffold; Cell adhesion; Cytoskeletal; Motility/polarity/chemotaxis P49023-2 5829 12q24.23 human Y88-p 448909 PQSSSPVyGSSAKTS Paxillin phosphorylation cell motility, altered; signaling pathway regulation; cell growth, altered 20133777 6 48 1343 Y88A mutation decreases PDGF-AA-induced phosphorylation of Akt T308 and Y473, p130CAS Y165 and SHP2 Y542 -Cacnb2 CACNB2 Channel, calcium Q8VGC3 116600 17q12.3 rat S625-p 469619 KQRSRHKsKDRYCDK intracellular localization 15311280 2 0 0 -GNAZ G-alpha(z) Endoplasmic reticulum; G protein, heterotrimeric; G protein, heterotrimeric alpha G((i/o/t/z)); Nuclear envelope P19086 2781 22q11.22-q11.23 human S16-p 451242 EKEAARRsRRIDRHL G-alpha activity, induced; protein conformation 9166747 3 0 2 -SLITRK1 SLITRK1 Cell development/differentiation; Membrane protein, integral Q96PX8 114798 13q31.1 human S695-p 4749248 DCGSHSLsD______ molecular association, regulation cell growth, altered 14-3-3 beta(INDUCES) 19640509 1 4 0 -NHERF2 NHERF-2 Adaptor/scaffold Q15599 9351 16p13.3 human T305-p 31858574 SGLHLSPtAAEAKEK EBP50_C molecular association, regulation signaling pathway regulation Ezrin(DISRUPTS) 26251448 1 1 0 -CCKBR CCKBR GPCR, family 1; Membrane protein, integral; Membrane protein, multi-pass; Receptor, GPCR P32239 887 11p15.4 human S437-p 17825901 IASLSRLsYTTISTL molecular association, regulation ARRB1(INDUCES) 21156802 1 0 0 -MACF1 ACF7 Actin-binding; Cytoskeletal; Motility/polarity/chemotaxis Q9UPN3 23499 1p34.3 human S7314-p 15427027 KSASRPGsRAGSRAG intracellular localization cell motility, induced; cytoskeletal reorganization 21295697 1 3 0 inhibits localization along microtubules, alters organization of microtubules, regulates skin wound repair, SC migration -LCP2 SLP76 Adaptor/scaffold Q13094 3937 5q35.1 human K266-sm 1878271702 KKPPFSDkPSIPAGR transcription, induced 31666306 1 1 0 enhances NFAT-driven IL-2 transcription -PRKCA PKCA EC 2.7.11.13; KINASE; Kinase, protein; Oncoprotein; Protein kinase, AGC; Protein kinase, Ser/Thr (non-receptor) P04409 282001 cow S657-p 448597 QSDFEGFsYVNPQFV Pkinase_C activity, induced; protein stabilization; protein conformation; phosphorylation; enzymatic activity, induced 8856079; 9013603; 9363767 28 4 2 -AR AR DNA-binding; Nuclear receptor; Transcription factor P10275 367 Xq12 human K610-ac 1877421608 TIDKFRRkNCPSCRL zf-C4 molecular association, regulation; intracellular localization carcinogenesis, induced; cell growth, induced; transcription, induced Ack(INDUCES) DNA(INDUCES) 35704598 1 1 0 -AGO2 AGO2 EC 3.1.26.n2; RNA processing; RNA-binding Q9UKV8 27161 8q24.3 human S672-p 1873647700 IFYRDGVsEGQFQQV Piwi molecular association, regulation DNA repair, induced DNA(INDUCES) 34039517 1 1 0 -Creb1 CREB DNA-binding; Transcription factor Q01147 12912 1 C2|1 32.74 cM mouse S128-p 448547 RKILNDLsSDAPGVP pKID activity, induced neural plasticity; transcription, induced; transcription, altered 11970866; 34607805 11 20 2 -MORC3 MORC3 Cell cycle regulation; RNA-binding Q14149 23515 21q22.12 human K740-sm 14988620 EMNDKYVkKETCHQS molecular association, regulation PML(INDUCES) 20501696 1 2 0 -MCL1 MCL1 Apoptosis; Channel, misc.; Inhibitor; Membrane protein, integral; Mitochondrial Q07820 4170 1q21.2 human K308-ub 10837363 TKRDWLVkQRGWDGF Bcl-2 protein degradation 28522751 1 3 7 -Pak1 PAK1 EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, STE; Protein kinase, Ser/Thr (non-receptor) O88643 18479 7 E1|7 53.57 cM mouse T212-p 448176 VIEPLPVtPTRDVAT molecular association, regulation; intracellular localization; enzymatic activity, induced neural plasticity; cell growth, induced; cell motility, altered; cytoskeletal reorganization 11604394; 12176333; 12176334; 27583434; 36135748 17 27 19 -Prkcb PKCB iso2 EC 2.7.11.13; KINASE; Kinase, protein; Motility/polarity/chemotaxis; Protein kinase, AGC; Protein kinase, Ser/Thr (non-receptor) P68403-2 25023 1q36 rat T500-p 447896 WDGVTTKtFCGTPDY Pkinase enzymatic activity, induced 7961692 10 47 44 -MAPT Tau iso8 ACETYLTRANSFERASE; Acetyltransferase; Cytoskeletal P10636-8 4137 17q21.31 human T403-p 449131 SPVVSGDtSPRHLSN molecular association, regulation Tau iso8(INDUCES) 15190058 6 30 26 polymerized into filaments when 4?6 mol of phosphate per mol of tau were incorporated -PRKAA1 AMPKA1 Autophagy; EC 2.7.11.1; EC 2.7.11.26; EC 2.7.11.27; EC 2.7.11.31; KINASE; Kinase, protein; Protein kinase, CAMK; Protein kinase, Ser/Thr (non-receptor) Q13131 5562 5p13.1 human S494-p 4717473 GTATPQRsGSVSNYR AdenylateSensor phosphorylation 23623684 3 2 15 enhances T479 phosphorylation and T172 dephosphorylation -SETMAR SETMAR Amino Acid Metabolism - lysine degradation; EC 2.1.1.43; METHYLTRANSFERASE; Methyltransferase; Methyltransferase, protein lysine Q53H47 6419 3p26.1 human S508-p 10940417 LYDNRRRsAQWLDQE Transposase_1 protein stabilization; molecular association, regulation; activity, inhibited DNA repair, induced; chromatin organization, altered H3(INDUCES) 22231448; 25024738 2 18 2 Chk1 half-life increased; repression of replication fork restart, induce chromatin association in IR and its reversed in HU -Mapt Tau ACETYLTRANSFERASE; Acetyltransferase; Cytoskeletal P19332 29477 10q32.1 rat S513-p 447928 SGYSSPGsPGTPGSR molecular association, regulation; protein conformation neural plasticity PPP1CC(INDUCES) 28784767; 33519375; 36859689 175 57 116 -Shc1 SHC1 Adaptor/scaffold; Apoptosis; Mitochondrial; Motility/polarity/chemotaxis P98083 20416 3 F1|3 39.11 cM mouse Y423-p 448511 ELFDDPSyVNIQNLD activity, induced; molecular association, regulation; phosphorylation cell differentiation, altered; apoptosis, induced; cell growth, induced GRB2(INDUCES); SHIP(INDUCES) 11713219; 12101399; 14576154; 15930121; 20697350; 24837366; 9083021 42 91 1971 Shc3F breast tumor growth was significantly delayed, and display a significant increase in VEGF protein; in vitro and in vivo -NKD2 NKD2 Cell development/differentiation; Ubiquitin conjugating system Q969F2 85409 5p15.33 human S31-p 23254812 FVASAYAsGRKGAEE molecular association, regulation; intracellular localization signaling pathway regulation NKD2(INDUCES) 34433025 1 1 4 regulates ORAI1 localization and Ca2+-NFAT pathway -FANCD2 FANCD2 DNA repair, damage Q9BXW9 2177 3p25.3 human S898-p 1871613602 SECDPTPsHRGQLNK FancD2 molecular association, regulation; ubiquitination; intracellular localization; activity, inhibited cell cycle regulation; DNA repair, inhibited; signaling pathway regulation DNA(DISRUPTS) 31167143 1 1 0 inhibits Fanconi anemia pathway leading to inhibition of DNA repair; 882-898 cluster -HGS Hrs Adaptor/scaffold; Motility/polarity/chemotaxis O14964 9146 17q25.3 human Y334-p 450192 ARYLNRNyWEKKQEE intracellular localization; receptor recycling, altered; phosphorylation 12953068; 17101784 2 16 261 Hrs phosphorylation mutant Y329,334F is unable to degrade ubiquinated EGFR. ; Cbl expression alters Hrs phosphorylation and fractionation in membrane and cyosokic fractions. -CFTR CFTR Channel, chloride; EC 3.6.3.49; Hydrolase; Membrane protein, integral; Membrane protein, multi-pass; Transporter; Transporter, ABC family P13569 1080 7q31.2 human S707-p 2907509 SILNPINsIRKFSIV CFTR_R activity, induced 12588899 2 0 0 -Sh2b2 APS Adaptor/scaffold Q9Z200 114203 12q12 rat S588-p 456846 SARSRSNsTEHLLEA intracellular localization 16141217 1 2 0 -CMKLR1 CMKLR1 GPCR, family 1; Membrane protein, integral; Membrane protein, multi-pass; Receptor, GPCR Q99788 1240 12q23.3 human T255-p 32668900 QRNRLAKtKKPFKII 7tm_1 receptor internalization, induced 24658352 1 0 0 -PKP1 plakophilin 1 Cell adhesion; Motility/polarity/chemotaxis Q13835 5317 1q32.1 human T179-p 27717307 LGSKGQKtTQNRYSF activity, induced; protein stabilization cell motility, induced; cell growth, induced; translation, induced; cell adhesion, inhibited 23444369 1 1 0 -PAG1 PAG Adaptor/scaffold; Membrane protein, integral Q9NWQ8 55824 8q21.13 human Y317-p 450659 EEEISAMySSVNKPG PAG molecular association, regulation carcinogenesis, induced; cell growth, induced; apoptosis, inhibited LYN(INDUCES); CSK(INDUCES) 10790433; 17389760; 18070987; 25897081 9 31 643 -Npas4 NPAS4 DNA-binding Q8BGD7 225872 19|19 A mouse T427-p 1869686800 LVCTPPYtPHQPGGC molecular association, regulation neural plasticity; transcription, induced CBP(INDUCES) 31801086 1 1 0 -Hdac9 HDAC9 DEACETYLASE; Deacetylase; EC 3.5.1.98; Transcription, coactivator/corepressor Q99N13 79221 12|12 A3 mouse S240-p 4772328 KVAERRSsPLLRRKD intracellular localization 15546868 1 17 1 decreased nuclear localization -Nkx2-5 NKX2-5 DNA-binding P42582 18091 17 A3.3|17 13.6 cM mouse S163-p 465563 FKQQRYLsAPERDQL Homeodomain transcription, altered 9858576 1 0 1 -BRCA1 BRCA1 EC 6.3.2.-; Nuclear receptor co-regulator; Transcription, coactivator/corepressor; Tumor suppressor; UBIQUITIN LIGASE; Ubiquitin conjugating system; Ubiquitin ligase P38398 672 17q21.31 human S308-p 451604 KAEFCNKsKQPGLAR cell cycle regulation 26831064 2 0 0 mitotic microtubule assembly -Arrb2 ARRB2 Adaptor/scaffold Q91YI4 216869 11 B3|11 42.99 cM mouse K207-ub 6140808 HLEASLDkELYYHGE Arrestin_C molecular association, regulation mAChR M2(INDUCES); mAChR m1(INDUCES) 19055777 1 0 0 -PDPK1 PDK1 EC 2.7.11.1; KINASE; Kinase, protein; Nuclear receptor co-regulator; Protein kinase, AGC; Protein kinase, Ser/Thr (non-receptor) O15530 5170 16p13.3 human Y376-p 447695 DEDCYGNyDNLLSQF enzymatic activity, induced apoptosis, altered 11481331; 20044479; 20643654 8 1 0 -ASIC1 ASIC1 Channel, cation; Membrane protein, integral; Membrane protein, multi-pass; Transporter; Transporter, ion channel P78348 41 12q13.12 human S25-p 25554906 IQAFASSsTLHGLAH ASC activity, induced; intracellular localization signaling pathway regulation 22553040 1 0 0 increase the surface expression, pain hypersensitivity/ regulates BDNF-mediated mechanical hyperalgesia PI3K/Akt signaling pathway -Dpysl2 CRMP-2 Microtubule-binding; Motility/polarity/chemotaxis O08553 12934 14 D1|14 34.6 cM mouse T555-p 448084 DNIPRRTtQRIVAPP protein processing cell growth, inhibited; cytoskeletal reorganization; signaling pathway regulation; cell growth, altered 19735446; 20961402; 32860158 19 2 8 inhibits dendritic growth -Ppp1r1b DARPP-32 Motility/polarity/chemotaxis; Protein phosphatase, regulatory subunit Q6J4I0 360616 10q31 rat S137-p 448046 EEDEEEDsQAEVLKG DARPP-32 phosphorylation cell motility, induced; signaling pathway regulation 21564097; 7708705 13 4 15 Dephosphorylation of S137 by PPP3CAis inhibited. ; induces locomotion through the DARPP-32/PP1 signaling pathway -Prkcb PKCB EC 2.7.11.13; KINASE; Kinase, protein; Motility/polarity/chemotaxis; Protein kinase, AGC; Protein kinase, Ser/Thr (non-receptor) P68403 25023 1q36 rat T500-p 447896 WDGVTTKtFCGTPDY Pkinase enzymatic activity, induced 21215369 10 47 44 -DNM1L DRP1 Apoptosis; EC 3.6.5.5; Endoplasmic reticulum; Hydrolase; Microtubule-binding; Mitochondrial; Motor O00429 10059 12p11.21 human S637-p 483971 VPVARKLsAREQRDC activity, induced; molecular association, regulation; intracellular localization; enzymatic activity, inhibited; activity, inhibited; protein conformation cell cycle regulation; carcinogenesis, induced; carcinogenesis, inhibited; cell motility, induced; cell growth, inhibited; signaling pathway regulation; autophagy, induced; cell growth, induced; cell differentiation, induced; apoptosis, inhibited; cytoskeletal reorganization; autophagy, inhibited DRP1(NOT_REPORTED) 17553808; 18838687; 21646527; 25595902; 27540013; 28436948; 30091204; 31494243; 31992853; 32433544; 33802063; 33805672; 34038722; 34589283; 34963686; 35100966; 35297042; 35697672; 35739087; 35887094; 36162640; 36385754; 37024453; 37442283 103 3 0 -TFEB TFEB DNA-binding; Transcription factor P19484 7942 6p21.1 human S109-p 3181610 NKFAAHIsPAQGSPK MITF_TFEB_C_3_N activity, induced; intracellular localization transcription, inhibited; cell growth, altered 29945972 1 26 0 -CDC42EP4 CDC42EP4 Cytoskeletal Q9H3Q1 23580 17q25.1 human S80-p 35524901 SSKRSLLsRKFRGSK PBD molecular association, regulation cell motility, induced; cytoskeletal reorganization CDC42(DISRUPTS); ARHGEF17(INDUCES); PARD6G(INDUCES) 25086031 1 2 0 ARHGEF-phosphoCEP4 interaction activates Rac, activated Rac increased filopodium formation -BTK Btk EC 2.7.10.2; KINASE; Kinase, protein; Protein kinase, TK; Protein kinase, tyrosine (non-receptor) Q06187 695 Xq22.1 human S51-p 28710300 FERGRRGsKKGSIDV PH protein degradation; molecular association, regulation; ubiquitination; intracellular localization; phosphorylation signaling pathway regulation 14-3-3 zeta(INDUCES) 23754751 1 0 0 induces tyrosine phosphorylation and BCR signaling -STXBP5L STXBP5L Q9Y2K9 9515 3q13.33 human S800-p 34668139 SAACMEIsLPVTTEE protein degradation 25002582 1 1 0 ; in a multiple residue S->D mutant -ALK ALK EC 2.7.10.1; KINASE; Kinase, protein; Membrane protein, integral; Oncoprotein; Protein kinase, TK; Protein kinase, tyrosine (receptor) Q9UM73 238 2p23.2-p23.1 human Y1507-p 450379 TSLWNPTyGSWFTEK molecular association, regulation SHC1(NOT_REPORTED); IRS2(INDUCES); SHC3(INDUCES); SHC1(INDUCES) 17274988; 30459283 2 9 91 -PARP1 PARP1 DNA repair, damage; EC 2.4.2.30; Nuclear envelope; Nuclear receptor co-regulator; Nucleolus; Transferase P09874 142 1q42.12 human K508-m1 12261103 AALSKKSkGQVKEEG ADP-ribosylation; molecular association, regulation; enzymatic activity, induced DNA(INDUCES) 24088713 1 1 8 regulates ARTD1 recruitment to damaged chromation in DNA-damage dependent manner -ZC3HC1 NIPA Cell cycle regulation; Ubiquitin conjugating system Q86WB0 51530 7q32.2 human S395-p 478573 PGLEVPSsPLRKAKR molecular association, regulation; activity, inhibited cell cycle regulation SKP1A(DISRUPTS) 17389604; 27226629 3 54 24 -PIK3AP1 BCAP Adaptor/scaffold Q9DDT2 374268 chicken Y448-p 448184 PGSDEELyESMAGFV molecular association, regulation PIK3R1(INDUCES) 11163197 2 0 0 -Arpc1a ARPC1A Cytoskeletal; Motility/polarity/chemotaxis Q99PD4 81824 12p11 rat T21-p 283458503 HAWNRDRtQIALSPN molecular association, regulation cytoskeletal reorganization N-WASP(INDUCES) 28972183 1 0 0 -FLOT1 FLOT1 Adaptor/scaffold O75955 10211 6p21.33 human K51-ub 12322225 NTLTLNVkSEKVYTR Band_7 protein stabilization; intracellular localization carcinogenesis, induced Snail1(INDUCES) 30631151 1 0 1 translocation of Flot-1 to the nucleus, suppresses proteasomal degradation, promotes epithelial-to-mesenchymal transition (EMT) high metastatic potential -E2F1 E2F1 DNA-binding; Transcription factor Q01094 1869 20q11.22 human K164-ub 95155307 AEVLKVQkRRIYDIT E2F_TDP protein stabilization DNA repair, induced; cell growth, induced; transcription, induced DNA(INDUCES) 28542143 1 0 0 -PDP1 PDP1 EC 3.1.3.43; Mitochondrial; Motility/polarity/chemotaxis; PHOSPHATASE; Protein phosphatase, Ser/Thr (non-receptor) Q9P0J1 54704 8q22.1 human Y94-p 15422109 SILKANEySFKVPEF enzymatic activity, inhibited 24962578 2 1 0 -Gphn gephyrin Adaptor/scaffold; EC 2.10.1.1; EC 2.7.7.75 Q03555 64845 6q24 rat S337-p 481401 NILRASHsAVDITKV neural plasticity 25535349 1 31 5 promoted activity dependent inhibitory synapse formation and cluster size regulation -NR1H2 LXR-beta Nuclear receptor P55055 7376 19q13.33 human S431-p 1881579402 LVSLRTLsSVHSEQV carcinogenesis, induced; cell motility, induced; cell growth, induced; transcription, altered 37059993 1 0 0 -Snai1 Snail1 C2H2-type zinc finger protein; Transcription factor Q02085 20613 2 H3|2 87.33 cM mouse K98-ub 1872271900 LSDEDSGkSSQPPSP protein stabilization; molecular association, regulation carcinogenesis, inhibited; transcription, inhibited GSK3B(INDUCES) 16096638 2 0 0 induces EMT -IRS1 IRS1 Adaptor/scaffold; Motility/polarity/chemotaxis P35568 3667 2q36.3 human Y632-p 447565 GRKGSGDyMPMSPKS molecular association, regulation cell differentiation, induced; transcription, induced PIK3R1(INDUCES) 11416002; 12525499 12 13 288 -YAP1 YAP1 Oncoprotein; Transcription, coactivator/corepressor P46937 10413 11q22.1 human S61-p 484116 IVHVRGDsETDLEAL intracellular localization; activity, inhibited cell growth, induced; cell growth, inhibited; apoptosis, induced; cell motility, altered; cytoskeletal reorganization; transcription, inhibited 24658687; 25180175; 25751139; 28416665 13 47 1 sensitivity to gemcitabine -PIAS1 PIAS1 EC 6.3.2.-; Nuclear receptor co-regulator; SUMO LIGASE; SUMO conjugating system; SUMO ligase; Transcription, coactivator/corepressor O75925 8554 15q23 human S13-p 53747702 ELKQMVMsLRVSELQ protein degradation translation, inhibited 26157031 1 0 0 -SSH1 SSH1 EC 3.1.3.16; EC 3.1.3.48; PHOSPHATASE; Protein phosphatase, dual-specificity Q8WYL5 54434 12q24.11 human S834-p 10793641 KELERLKsVPADPAP molecular association, regulation; enzymatic activity, inhibited 14-3-3 beta(INDUCES) 21857021 1 5 1 -Tigit TIGIT Cell surface; Membrane protein, integral P86176 100043314 16|16 B4 mouse Y230-p 27266400 DYADPQEyFNVLSYR molecular association, regulation SHIP(INDUCES); ARRB2(INDUCES) 24817116 2 0 0 NF-kB activation is inhibited, IFN-gamma production inhibited -DNM1L DRP1 iso3 Apoptosis; EC 3.6.5.5; Endoplasmic reticulum; Hydrolase; Microtubule-binding; Mitochondrial; Motor O00429-3 10059 12p11.21 human S611-p 483971 VPVARKLsAREQRDC molecular association, regulation SMCR7(DISRUPTS) 29899447 103 3 0 phosphomimetic mutant S611D failed to bind to SMCR7 (aka MID49). -Scn2a SCN2A Channel, sodium; Membrane protein, integral; Membrane protein, multi-pass P04775 24766 3q21 rat S1124-p 6003506 LNTEEFSsESDMEES Na_trans_assoc intracellular localization 19064667 1 0 0 regulates SCN2A accumulation at the axonal initial segment (AIS) and interaction with ankyrin G -CALCA CALCA Secreted; Secreted, signal peptide P01258 796 11p15.2 human T97-p 1871177713 TCMLGTYtQDFNKFH Calc_CGRP_IAPP protein conformation 33220304 0 1 0 inhibits fibril formation and growth -Cebpb C/EBP-beta DNA-binding; Motility/polarity/chemotaxis; Transcription factor P21272 24253 3q42 rat K216-ac 458939 APAKAKAkKAVDKLS transcription, inhibited 24344329 4 0 0 -NTRK1 TrkA iso2 EC 2.7.10.1; KINASE; Kinase, protein; Membrane protein, integral; Oncoprotein; Protein kinase, TK; Protein kinase, tyrosine (receptor) P04629-2 4914 1q23.1 human Y490-p 447762 HIIENPQyFSDACVH activity, induced; intracellular localization; enzymatic activity, induced; phosphorylation cell differentiation, induced 27655914; 29229648; 9099755 23 0 2 neurite outgrowth and differentiation -PTK2 FAK EC 2.7.10.2; KINASE; Kinase, protein; Protein kinase, TK; Protein kinase, tyrosine (non-receptor) Q05397 5747 8q24.3 human Y925-p 447966 DRSNDKVyENVTGLV Focal_AT protein stabilization; molecular association, regulation; intracellular localization; activity, inhibited; enzymatic activity, induced; phosphorylation carcinogenesis, induced; cell motility, induced; cell adhesion, induced; signaling pathway regulation; transcription, altered; cell differentiation, altered; cell growth, induced; chromatin organization, altered; apoptosis, inhibited; cell motility, altered; cell adhesion, altered; cytoskeletal reorganization PXN(DISRUPTS); GRB2(INDUCES) 10821872; 11839732; 12754219; 15735019; 18032789; 18437915; 21289086; 21852560; 27226554; 29954829; 32107290; 33761359; 35682554; 35982848; 7597091 104 17 427 -YY2 YY2 C2H2-type zinc finger protein O15391 404281 Xp22.12 human K247-m1 1873286916 KVKPKRSkGEPPKTV molecular association, regulation cell cycle regulation; carcinogenesis, induced; cell growth, induced; transcription, altered DNA(INDUCES) 29098080 1 1 0 mutant K247R tumors were in general heavier and larger than YY2 WT; 1/3 genes positively regulated by SETD7 and negatively regulated by LSD1; regulated binding af?nity with endogenous genomic loci -Stat4 STAT4 DNA-binding; Transcription factor P42228 20849 1 C1.1|1 26.67 cM mouse Y694-p 447790 TERGDKGyVPSVFIP activity, induced; molecular association, regulation; intracellular localization; activity, inhibited; phosphorylation cell differentiation, altered; transcription, altered; cell growth, altered FHL1 iso1(INDUCES) DNA(INDUCES) 10961885; 12213961; 15963787 10 5 8 phosphorylation of STAT4 S722 -ANXA2 ANXA2 Calcium-binding; Lipid-binding; Motility/polarity/chemotaxis P07355 302 15q22.2 human Y24-p 449483 HSTPPSAyGSVKAYT molecular association, regulation; intracellular localization; phosphorylation carcinogenesis, induced; cell growth, induced; cell motility, induced; transcription, induced; signaling pathway regulation Myc(INDUCES); EGFR(INDUCES); STAT3(INDUCES) 15302870; 18990701; 23555942; 25136068; 26272794; 26307676; 26716413; 28130864; 28470457; 30081903; 30738042; 31113450; 32615410; 33941853; 34502195; 36229838 29 64 2613 induces ERK1/2 signaling -Zfp24 ZNF24 C2H2-type zinc finger protein; DNA-binding; Transcription factor Q91VN1 59057 18|18 A2 mouse T302-p 1244446 VQHQRVHtGEKPYKC molecular association, regulation cell differentiation, inhibited; transcription, inhibited DNA(DISRUPTS) 29786073; 29791837 2 5 6 regulates oligodendrocyte differentiation and CNS myelination; mediates the expression of Sox10 and Myrf; oligodendrocyte differentiation and myelination -CNN3 calponin 3 Cytoskeletal; Motility/polarity/chemotaxis Q15417 1266 1p21.3 human S296-p 4776198 GTNGSEIsDSDYQAE molecular association, regulation cytoskeletal reorganization 20861310 2 4 9 stimulates dissociation of calponin 3 from actin cytoskeleton (F-actin) -NTRK1 TrkA iso2 EC 2.7.10.1; KINASE; Kinase, protein; Membrane protein, integral; Oncoprotein; Protein kinase, TK; Protein kinase, tyrosine (receptor) P04629-2 4914 1q23.1 human Y674-p 447763 RDIYSTDyYRVGGRT PK_Tyr_Ser-Thr activity, induced; intracellular localization; enzymatic activity, induced; phosphorylation cell differentiation, induced 27655914; 29229648; 9099755 14 3 10 neurite outgrowth and differentiation -Ctnnb1 CTNNB1 Actin-binding; Cell adhesion; Motility/polarity/chemotaxis; Nuclear receptor co-regulator; Oncoprotein; Transcription factor Q02248 12387 9 F4|9 72.19 cM mouse S191-p 467710 SRHAIMRsPQMVSAI intracellular localization 18423204 5 45 11 -XRCC1 XRCC1 DNA repair, damage P18887 7515 19q13.31 human S416-p 3181468 SSEEDEAsHSGGSGD molecular association, regulation PARP1(DISRUPTS) 25477519 1 4 0 -ATF2 ATF-2 ACETYLTRANSFERASE; C2H2-type zinc finger protein; EC 2.3.1.48; Transcription factor P15336 1386 2q31.1 human K357-ac 1910100 DPDEKRRkFLERNRA bZIP_1 cell growth, inhibited; cell motility, inhibited; transcription, induced; transcription, altered 17590016; 33178766 2 1 0 -Il22ra1 IL22RA1 Membrane protein, integral Q80XZ4 230828 4 D3|4 67.99 cM mouse S414-p 33373903 VEDSGKDsTPGILST protein stabilization 24742671 1 0 0 -CTDSPL2 CTDSPL2 EC 3.1.3.-; Motility/polarity/chemotaxis; PHOSPHATASE; Phosphatase Q05D32 51496 15q15.3-q21.1 human T86-p 469354 DNNLITStPRAGEKP cell cycle regulation; carcinogenesis, induced; cell motility, induced; cell growth, induced; transcription, inhibited 34813892 1 17 38 -Tsc2 TSC2 Cell cycle regulation; GAP; GAP, misc.; Nuclear receptor co-regulator; Tumor suppressor Q61037 22084 17 A3.3|17 12.41 cM mouse S1388-p 450212 QPLSKSSsSPELQTL phosphorylation transcription, altered; signaling pathway regulation; translation, inhibited 32912901 19 14 6 inhibits S6 and ULK1 phosphorylation through inhibiting mTORC1 signaling -H3c1 H3 DNA-binding P68433 360198 13|13 A3.1 mouse K56-ac 3804954 REIRRYQkSTELLIR Histone acetylation cell differentiation, inhibited; endocytosis, altered; cell adhesion, altered; transcription, induced 20404188; 32265492; 33195484 33 14 2 SIRT6 inhibits acetylated H3 and AKT signaling ; axon guidance; Histone acetylation induces AKT signaling at AKT promoter -PITX1 PITX1 Cell development/differentiation; DNA-binding; Transcription factor P78337 5307 5q31.1 human Y175-p 54204602 VQPYEDVyAAGYSYN protein degradation; protein stabilization transcription, inhibited 26840794; 27752061 2 0 0 -STAT3 STAT3 DNA-binding; Motility/polarity/chemotaxis; Nuclear receptor co-regulator; Transcription factor P40763 6774 17q21.2 human K163-me 1881268801 QDLEQKMkVVENLQD activity, induced signaling pathway regulation 33742125 1 1 0 partially inhibits angiogenic function of STAT3 in vitro and in vivo -CSNK1A1 CK1A EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, CK1; Protein kinase, Ser/Thr (non-receptor) P48729 1452 5q32 human K65-ub 15490106 LYESKLYkILQGGVG Pkinase protein degradation 26909574 1 5 2 -CTBP1 CTBP1 Cell cycle regulation; EC 1.1.1.-; Nuclear receptor co-regulator; Oxidoreductase; Transcription, coactivator/corepressor Q13363 1487 4p16.3 human S422-p 455350 AHPPHAPsPGQTVKP protein degradation apoptosis, induced 14567915; 15708980; 16984892 3 2 0 in H1299 cells lacking p53 -Brsk1 BRSK1 EC 2.7.11.1; EC 2.7.11.26; KINASE; Kinase, protein; Protein kinase, CAMK; Protein kinase, Ser/Thr (non-receptor) Q5RJI5 381979 7|7 A1 mouse T189-p 456027 VGDSLLEtSCGSPHY Pkinase intracellular localization; enzymatic activity, induced cytoskeletal reorganization BRSK1(INDUCES) 17482548; 29698519 8 1 0 activation of Sad kinases in the axon during development; Sad kinases are required for the survival of cortical neurons; LKB1 phosphorylates Brsk1 and Brsk2. -KIF2B KIF2B Microtubule-binding; Motor Q8N4N8 84643 17q22 human T125-p 25247520 MIPQKNQtASGDSLD cell cycle regulation; cytoskeletal reorganization 22535524 1 1 0 involved in the corrections of k-MT attachment errors in early mitosis, microtubule depolymerization activity -Csk CSK EC 2.7.10.2; KINASE; Kinase, protein; Protein kinase, TK; Protein kinase, tyrosine (non-receptor) P41241 12988 9 B|9 31.18 cM mouse Y18-p 41510404 GTECIAKyNFHGTAE SH3_1 protein degradation; ubiquitination; phosphorylation; enzymatic activity, induced carcinogenesis, induced 36376335 1 1 1 regulates LCK phosphorylation and activity -Syk Syk EC 2.7.10.2; KINASE; Kinase, protein; Protein kinase, TK; Protein kinase, tyrosine (non-receptor) Q64725 25155 17p14 rat Y625-p 459327 LRLRNYYyDVVN___ molecular association, regulation; phosphorylation; enzymatic activity, induced FCER1G(INDUCES) 20554527 3 2 2 mutation of this site stimulates phosphorylation of Y317, Y519 and Y520; required for activation of ERK1/2 and p38MAP kinases; required for activation of NFAT and NFkB -NQO1 NQO1 EC 1.6.5.2; Oxidoreductase P15559 1728 16q22.1 human S82-p 13910234 AYKEGHLsPDIVAEQ Flavodoxin_2 protein degradation; protein stabilization; molecular association, regulation; enzymatic activity, inhibited; protein conformation p73(DISRUPTS) Other(DISRUPTS) 30243998; 34817874; 36096178 3 14 0 -EPHA2 EphA2 EC 2.7.10.1; KINASE; Kinase, protein; Membrane protein, integral; Protein kinase, TK; Protein kinase, tyrosine (receptor) P29317 1969 1p36.13 human Y921-p 457515 ESIKMQQyTEHFMAA SAM_1 molecular association, regulation GRB2(INDUCES); SHIP-2(INDUCES) 24825902 1 7 24 -ITGB7 ITGB7 Cell adhesion; Membrane protein, integral; Motility/polarity/chemotaxis; Receptor, misc. P26010 3695 12q13.13 human Y753-p 469601 YRLSVEIyDRREYSR Integrin_b_cyt cell adhesion, altered 16874740 1 0 1 -BPTF FALZ DNA-binding; Transcription factor Q12830 2186 17q24.2 human K942-ub 52485010 KAVQMCSkPREFALA protein degradation 26676607 0 2 0 -CXCR4 CXCR4 GPCR, family 1; Membrane protein, integral; Membrane protein, multi-pass; Receptor, GPCR P61073 7852 2q22.1 human Y135-p 1869808401 AFISLDRyLAIVHAT 7tm_1 activity, induced carcinogenesis, induced; cell motility, induced 31562188 1 0 0 -PRKDC DNAPK DNA repair, damage; EC 2.7.11.1; KINASE; Kinase, protein; Nucleolus; Protein kinase, Ser/Thr (non-receptor); Protein kinase, atypical P78527 5591 8q11.21 human S2677-p 31875303 HTSPSSDsLLFAHKR DNAPKcs_CC5 DNA repair, inhibited 24687855 1 1 0 cell survival inhibited -NKX2-1 NKX2-1 Cell development/differentiation; DNA-binding; Transcription factor P43699 7080 14q13.3 human K151-ub 1877644900 GSLGDVSkNMAPLPS protein degradation; ubiquitination cell growth, inhibited; cell motility, inhibited 30849519 1 0 0 -CBS CBS Amino Acid Metabolism - cysteine and methionine; Amino Acid Metabolism - glycine, serine and threonine; EC 4.2.1.22; Lyase; Other Amino Acids Metabolism - selenoamino acid P35520 875 21q22.3 human S227-p 50301801 LDQYRNAsNPLAHYD PALP enzymatic activity, induced 26368121 2 0 0 -VAV1 VAV1 GEF; GEF, Rac/Rho; Motility/polarity/chemotaxis; Oncoprotein P15498 7409 19p13.3 human Y142-p 448809 SVGDEDIySGLSDQI molecular association, regulation cell motility, induced PLCG1(INDUCES); Lck(INDUCES); PIK3R1(INDUCES) 17050525; 29058761 6 2 0 neutrophil crawling behavior -Slc12a3 NCCT Membrane protein, integral; Membrane protein, multi-pass; Transporter; Transporter, SLC family P55018 54300 19p13-p12 rat S124-p 4709872 EDETGANsEKSPGEP activity, induced 22966159 1 2 0 -CCR7 CCR7 GPCR, family 1; Membrane protein, integral; Membrane protein, multi-pass; Motility/polarity/chemotaxis; Receptor, GPCR P32248 1236 17q21.2 human T375-p 455290 VEAETTTtFSP____ phosphorylation 15054093 1 0 0 ERK1/2 phosphorylation -Akt1 Akt1 EC 2.7.11.1; KINASE; Kinase, protein; Oncoprotein; Protein kinase, AGC; Protein kinase, Ser/Thr (non-receptor) P31750 11651 12 F1|12 61.2 cM mouse Y315-p 448519 TFCGTPEyLAPEVLE Pkinase enzymatic activity, induced apoptosis, altered 11445557; 20606012 5 2 13 -PARD3 PAR3-alpha Adaptor/scaffold; Motility/polarity/chemotaxis Q8TEW0 56288 10p11.22-p11.21 human S889-p 455653 LGLKKSSsLESLQTA molecular association, regulation 14-3-3 zeta(INDUCES) 15721295 4 1 0 -ARRB2 ARRB2 Adaptor/scaffold P32121 409 17p13.2 human S14-p 23083983 TRVFKKSsPNCKLTV receptor internalization, induced 26324936 2 1 1 -SPATA13 SPATA13 GEF; GEF, Rac/Rho Q96N96 221178 13q12.12 human S106-p 33670315 SDGGTEPsALVDDNG activity, induced cell motility, induced; cell adhesion, altered 24874604 1 1 0 Rac activation, regulates adhesion turnover, SPATA13 GEF activity promoted -Cebpb C/EBP-beta DNA-binding; Motility/polarity/chemotaxis; Transcription factor P28033 12608 2 H3|2 87.58 cM mouse T217-p 448447 AKAKAKKtVDKLSDE molecular association, regulation cell cycle regulation; apoptosis, inhibited; cell growth, altered CASP8(INDUCES); CASP1(INDUCES) 10635333; 11684016 4 0 0 -ATXN10 ataxin-10 Cell development/differentiation Q9UBB4 25814 22q13.31 human S12-p 14159379 RPPPARLsGVMVPAP molecular association, regulation; intracellular localization PLK1(INDUCES) 25666058 1 16 0 associates with midbody, -BID BID Apoptosis; Mitochondrial P55957 637 22q11.21 human S64-p 1880042000 LQTDGNRsSHSRLGR cell differentiation, induced; apoptosis, inhibited 36202990 1 0 0 -CTNNB1 CTNNB1 Actin-binding; Cell adhesion; Motility/polarity/chemotaxis; Nuclear receptor co-regulator; Oncoprotein; Transcription factor P35222 1499 3p22.1 human T332-p 29614600 VNIMRTYtYEKLLWT apoptosis, induced; transcription, inhibited 24117889 1 0 0 -ADRB2 ADRB2 GPCR, family 1; Membrane protein, integral; Membrane protein, multi-pass; Receptor, GPCR P07550 154 5q32 human Y219-p 4047200 LVIMVFVySRVFQEA 7tm_1; TM activity, induced; receptor internalization, induced; molecular association, regulation; intracellular localization; phosphorylation ARRB1(INDUCES) 17925438; 30131371 2 0 0 regulates localization of B-Arrestin2, induces activation of ERK2, induces phosphorylation at S355 and S356 -RAB7A Rab7 G protein; G protein, monomeric; G protein, monomeric, Rab P51149 7879 3q21.3 human K191-ub 12301985 NEFPEPIkLDKNDRA activity, inhibited carcinogenesis, inhibited; autophagy, inhibited MON1A(DISRUPTS) 33846303 2 4 43 -SNAP23 SNAP23 Vesicle O00161 8773 15q15.1-q15.2 human S110-p 455977 WGDGGENsPCNVVSK SNAP-25 exocytosis, induced 29339438 3 60 1 promoting MVB?PM fusion and the release of CD63-enriched exosomes -SQLE SQLE EC 1.14.13.132; Endoplasmic reticulum; Lipid Metabolism - steroid biosynthesis; Membrane protein, integral; Membrane protein, multi-pass; Oxidoreductase Q14534 6713 8q24.13 human S87-p 1877421602 WAKSPPEsENKEQLE protein degradation; molecular association, regulation; ubiquitination carcinogenesis, inhibited; cell growth, inhibited; apoptosis, induced MARCH6(INDUCES) 35767703 1 0 0 -Adrb2 ADRB2 GPCR, family 1; Membrane protein, integral; Membrane protein, multi-pass; Receptor, GPCR P04274 101836719 hamster Y350-p 449808 RRSSSKAyGNGYSSN molecular association, regulation; receptor desensitization, altered Src iso1(INDUCES) 11278940 8 0 0 -MAPT Tau iso8 ACETYLTRANSFERASE; Acetyltransferase; Cytoskeletal P10636-8 4137 17q21.31 human K274-ac 27738305 KHQPGGGkVQIINKK Tubulin-binding intracellular localization; protein conformation cytoskeletal reorganization TUBA1A(DISRUPTS) 27356871; 31036717 4 0 0 K274Q mutant changes secondary structure of tau; enhances tau aggregation: reducesits ability to induce microtubule bundling in neuroblastoma cells; enhanced the flament formation -Sik1 SIK EC 2.7.11.1; KINASE; Kinase, protein; Motility/polarity/chemotaxis; Protein kinase, CAMK; Protein kinase, Ser/Thr (non-receptor); Tumor suppressor Q60670 17691 17 B1|17 17.25 cM mouse S577-p 465992 FQEGRRAsDTSLTQG molecular association, regulation; intracellular localization transcription, induced; signaling pathway regulation; transcription, altered 14-3-3 beta(INDUCES) 12200423; 12530631; 32457359 10 21 4 PKA-SIK signaling for the regulation of sleep need -MDM2 MDM2 EC 6.3.2.-; EC 6.3.2.19; Inhibitor; Ligase; NEDDYLATION LIGASE; Neddylation Ligase; Nucleolus; Oncoprotein; UBIQUITIN LIGASE; Ubiquitin conjugating system; Ubiquitin ligase Q00987 4193 12q15 human S260-p 454923 SLDSEDYsLSEEGQE activity, induced; protein degradation; molecular association, regulation; ubiquitination; enzymatic activity, induced Rb(DISRUPTS) 12167711; 12383858; 19833129; 21990374 7 1 0 promotes p53 degradation; stimulates p53 turnover; Rb degradation ; Phosphorylated S260 and S395 and S260D and S395D mutant peptides inhibited binding of binding of a specific monoclonal antibody raised to Mdm2. Phosphorylation of Mdm2 regulates p53 degradation. -Trpv1 TRPV1 Channel, cation; Membrane protein, integral; Membrane protein, multi-pass; Receptor, misc. O35433 83810 10q24 rat Y199-p 458384 ASYTDSYyKGQTALH Ank_2 activity, induced 17582331 2 0 0 altered desensitization -BRAF BRAF EC 2.7.11.1; KINASE; Kinase, protein; Oncoprotein; Protein kinase, Ser/Thr (non-receptor); Protein kinase, TKL P15056 673 7q34 human S732-p 23085408 HRSASEPsLNRAGFQ molecular association, regulation; phosphorylation BRAF(DISRUPTS); 14-3-3 beta(DISRUPTS) 37625591 1 0 3 inhibits phosphorylation of itself at T599 and also MEK phosphorylation -Slc2a4 GLUT4 Membrane protein, integral; Membrane protein, multi-pass; Transporter; Transporter, SLC family P19357 25139 10q24 rat S488-p 451207 ATFRRTPsLLEQEVK intracellular localization 9725807 3 11 0 S488A mutation had no effect on localization to cell surface, but vesicle localization was significantly increased. -CLK2 CLK2 EC 2.7.12.1; KINASE; Kinase, protein; Protein kinase, CMGC; Protein kinase, dual-specificity (non-receptor) P49760 1196 1q22 human S34-p 15339201 HKRRRSRsWSSSSDR apoptosis, altered; cell growth, altered 20682768 1 0 0 -RBM7 RBM7 RNA-binding Q9Y580 10179 11q23.2 human S204-p 4033285 QRKVRMNsYPYLADR molecular association, regulation 14-3-3 beta(INDUCES); GADD45A(DISRUPTS) 25189701 1 21 61 14-3-3 protein binding -TWIST1 TWIST1 Cell development/differentiation; DNA-binding; Inhibitor; Transcription regulation Q15672 7291 7p21.1 human K38-ub 58948903 SGKRGGRkRRSSRRS protein stabilization; intracellular localization carcinogenesis, induced; cell motility, induced; cell growth, induced; transcription, induced 27618486 1 0 0 regulates EMT and cancer-stem cell self-renewal -Adcy6 ADCY6 Adenylyl cyclase; EC 4.6.1.1; Lyase; Membrane protein, integral; Membrane protein, multi-pass; Nucleotide Metabolism - purine; Transporter; Transporter, aquaporin family AAA40678 25289 7q36 rat S754-p 467275 IVRSRVHsTAVGVFS enzymatic activity, induced 11327830; 15470083 2 0 0 increases potentiation -Osbpl3 OSBPL3 iso3 Endoplasmic reticulum D3Z194 71720 6|6 B2.3 mouse S302-p 3212430 SGPVRLHsSNPNLST apoptosis, inhibited 31509750 1 11 0 inhibits insulin secretion -LMNA lamin A/C Cytoskeletal P02545 4000 1q22 human T19-p 459855 SGAQASStPLSPTRI molecular association, regulation cell cycle regulation lamin A/C(DISRUPTS) 35839855; 7925482 3 54 56 dominant negative mitotic affects, and mitotic assembly and disassembly of lamin -CYSLTR1 CYSLTR1 GPCR, family 1; Membrane protein, integral; Membrane protein, multi-pass; Receptor, GPCR Q9Y271 10800 Xq21.1 human S315-p 11143521 TFRKHSLsSVTYVPR receptor desensitization, induced transcription, induced 22230957 1 2 2 -HDAC4 HDAC4 DEACETYLASE; Deacetylase; EC 3.5.1.98; Hydrolase; Nuclear receptor co-regulator; SUMO LIGASE P56524 9759 2q37.3 human S632-p 448490 RPLSRAQsSPASATF protein stabilization; molecular association, regulation; intracellular localization transcription, altered 14-3-3 beta(INDUCES); 14-3-3 epsilon(INDUCES) 10869435; 10958686; 24904057 11 40 71 -Tp53 p53 Activator; DNA-binding; Motility/polarity/chemotaxis; Nuclear receptor co-regulator; Transcription factor; Tumor suppressor P10361 24842 10q24 rat K371-ac 458980 SSYPKTKkGQSTSRH activity, induced cell cycle regulation; apoptosis, induced 18192848; 22981429 95 4 0 -STAP2 STAP2 Adaptor/scaffold Q9UGK3 55620 19p13.3 human Y250-p 478353 PFLLDEDyEKVLGYV phosphorylation signaling pathway regulation; transcription, altered 12540842; 35725273 4 3 29 induces phosphorylation of ZAP-70, PLC-g1, ERK, and p38 thus inducing the TCR-proximal signaling pathway -NUMA1 NuMA-1 Cell cycle regulation; Motility/polarity/chemotaxis Q14980 4926 11q13.4 human T1811-p 1245323 TRSARRRtTQIINIT cell growth, induced; apoptosis, inhibited 23097092 2 12 192 cell proliferation increased -PAPOLA PAP-alpha EC 2.7.7.19; RNA processing; RNA splicing; Transferase P51003 10914 14q32.2 human K736-ac 483063 ANPIPVIkNSIKLRL protein stabilization; molecular association, regulation; enzymatic activity, inhibited; intracellular localization CPSF6(DISRUPTS); CFIM25(DISRUPTS) 17172643; 18281463 2 1 0 -BCAR1 P130Cas Adaptor/scaffold; Motility/polarity/chemotaxis P56945 9564 16q23.1 human S639-p 470438 IQSRPLPsPPKFTSQ intracellular localization cell motility, altered 19454314 2 15 0 -SENP3 SENP3 DESUMOYLASE; EC 3.4.22.68; Nucleolus; Protease; Sumo-specific protease Q9H4L4 26168 17p13.1 human S25-p 4172600 PGIPPAYsSPRRERL molecular association, regulation; intracellular localization NPM1(INDUCES) 25288641 1 4 6 ribosome biogenesis-28S rRNA maturation -GRIN2A NMDAR2A Channel, ligand-gated; Membrane protein, integral; Membrane protein, multi-pass Q12879 2903 16p13.2 human S929-p 485949 ADFIQRGsLIMDMVS NMDAR2_C activity, induced; receptor desensitization, inhibited 23503100; 34252035 2 9 0 -Slc12a2 NKCC1 Membrane protein, integral; Membrane protein, multi-pass; Transporter; Transporter, SLC family P55012 20496 18 D3|18 32.15 cM mouse T196-p 467235 HQQYYYDtHTNTYYL AA_permease_N enzymatic activity, induced 26069258 11 1 0 Ischemic cell death -Jak2 JAK2 EC 2.7.10.2; KINASE; Kinase, protein; Oncoprotein; Protein kinase, TK; Protein kinase, tyrosine (non-receptor) Q62120 16452 19 C1|19 23.73 cM mouse Y570-p 451494 VRREVGDyGQLHKTE PK_Tyr_Ser-Thr enzymatic activity, inhibited 15143187; 16705160; 19364823 8 40 825 -TUFM EFTU Mitochondrial; RNA-binding; Translation; Translation elongation P49411 7284 16p11.2 human S222-p 1871246005 ETPVIVGsALCALEG GTP_EFTU molecular association, regulation autophagy, inhibited ATG5(DISRUPTS) 33113344 1 0 0 mitophagy inhibited -CTNND1 CTNND1 Actin-binding; Adaptor/scaffold; Cell adhesion; G protein regulator, misc.; Motility/polarity/chemotaxis O60716 1500 11q12.1 human K547-ub 1873286914 ERSEARRkLRECDGL cell motility, induced; cytoskeletal reorganization 29078376 1 0 0 inhibits Rac1 activation -NELFE RDBP Mitochondrial; Transcription, coactivator/corepressor P18615 7936 6p21.33 human S51-p 454289 GGVKRSLsEQPVMDT molecular association, regulation transcription, induced 14-3-3 epsilon(INDUCES) 29523821 1 50 3 dissociation of the NELF complex from chromatin, which is accompanied by RNA polymerase II elongation -SQSTM1 SQSTM1 Autophagy; Nuclear receptor co-regulator; Ubiquitin conjugating system Q13501 8878 5q35.3 human Y433-p 11112748 AALDTIQySKHPPPL UBA_5 protein stabilization; molecular association, regulation; activity, inhibited carcinogenesis, induced; autophagy, inhibited SQSTM1(INDUCES) 31931029 1 1 2 inhibits cargo function -Marcks MARCKS Actin-binding; Motility/polarity/chemotaxis P26645 17118 10 B1|10 19.49 cM mouse S163-p 451837 SFKLSGFsFKKSKKE MARCKS intracellular localization carcinogenesis, induced; cell motility, altered 20211725 11 76 93 -MAD1L1 MAD1L1 Cell cycle regulation; Cytoskeletal Q9Y6D9 8379 7p22.3 human S214-p 482335 KIQELQAsQEARADH MAD molecular association, regulation; protein conformation; phosphorylation cell cycle regulation; carcinogenesis, induced; DNA repair, induced; signaling pathway regulation Mad2(INDUCES); Ku80(INDUCES) 24728176; 32944396 2 3 2 induces DNAPK phosphorylation, regulates MAD1/KU80 pathway; homodimerization -RASSF1 RASSF1 iso2 Tumor suppressor Q9NS23-2 11186 3p21.31 human S178-p 13258705 VRPVSVPsSKKPPSL molecular association, regulation apoptosis, inhibited TRAIL-R1(DISRUPTS); 14-3-3 zeta(INDUCES); 14-3-3 epsilon(INDUCES); TNF-R1(DISRUPTS); MOAP1(DISRUPTS) 20069457 1 0 0 -ANXA1 ANXA1 Calcium-binding; Lipid-binding P04083 301 9q21.13 human S5-p 452051 ___MAMVsEFLKQAW molecular association, regulation; protein conformation S100A11(DISRUPTS) 21280599 3 8 0 prevents the N-terminal peptide of ANXA1 from adopting an alpha-helical conformation -CXCR2 IL8RB GPCR, family 1; Membrane protein, integral; Membrane protein, multi-pass; Receptor, GPCR; Receptor, cytokine P25025 3579 2q35 human S351-p 451047 SRPSFVGsSSGHTST protein degradation; receptor desensitization, altered; receptor internalization, altered 9079638 1 0 1 -Dync1li1 DNCLI1 Cell cycle regulation; Cytoskeletal; Microtubule-binding; Motility/polarity/chemotaxis; Motor Q9QXU8 252902 8q32 rat T213-p 3217776 ASPQRRAtAAQEDRD DLIC intracellular localization 24778311 1 1 5 virus transport to the nucleus, promotes binding to adenovirus, decrease in dynein activity at lysosomes -Rock2 ROCK2 EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, AGC; Protein kinase, Ser/Thr (non-receptor) Q62868 25537 6q16 rat T414-p 5931301 QLPFIGFtYFRENLL enzymatic activity, inhibited 19099536 1 0 0 in vitro -EIF2AK2 PKR EC 2.7.10.2; EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, Other; Protein kinase, Ser/Thr (non-receptor); Protein kinase, tyrosine (non-receptor); Translation P19525 5610 2p22.2 human T451-p 448089 KRTRSKGtLRYMSPE Pkinase phosphorylation; enzymatic activity, induced apoptosis, induced; transcription, induced; translation, induced 11337501; 34380029; 35354045; 35947956; 9528799 15 1 0 -NCSTN nicastrin Membrane protein, integral Q92542 23385 1q23.2 human S437-p 25533000 FLRARNIsGVVLADH Nicastrin protein degradation; molecular association, regulation 22590650 1 0 0 inhibits gamma-secretase complex formation -Bcl11b Bcl-11B C2H2-type zinc finger protein; Nuclear receptor co-regulator; Transcription regulation Q99PV8 58208 12 F1|12 59.1 cM mouse S381-p 4772890 SSTPPPVsPGRGNPM molecular association, regulation SENP1(INDUCES) 22700985 0 16 56 -SIK3 QSK EC 2.7.11.1; KINASE; Kinase, protein; Motility/polarity/chemotaxis; Protein kinase, CAMK; Protein kinase, Ser/Thr (non-receptor) Q9Y2K2 23387 11q23.3 human S626-p 3216774 FSPVRRFsDGAASIQ molecular association, regulation 14-3-3 beta(INDUCES) 22588126 1 41 6 -Kalrn kalirin EC 2.7.11.1; GEF; GEF, Rac/Rho; KINASE; Kinase, protein; Protein kinase, CAMK; Protein kinase, Ser/Thr (non-receptor) A2CG49 545156 16|16 B3 mouse T1572-p 3363402 EPIQLPKtPAKLRNN enzymatic activity, induced cytoskeletal reorganization 18628310 1 0 1 -GAPDH GAPDH Carbohydrate Metabolism - glycolysis and gluconeogenesis; EC 1.2.1.12; Oxidoreductase P04406 2597 12p13.31 human K251-ac 14791500 DLTCRLEkPAKYDDI Gp_dh_C intracellular localization 20601085 1 0 0 nuclear translocation -DEF6 DEF6 GEF; GEF, Rac/Rho Q9H4E7 50619 6p21.31 human Y222-p 18505504 QDVLKQGyLWKRGHL PH molecular association, regulation; intracellular localization; protein conformation DCP1A(INDUCES) 22829599 1 1 0 cytoplasmic granule formation -Cdk5r1 CDK5R1 Protein kinase, regulatory subunit P61810 116671 10q26 rat T138-p 471393 PAITSAGtPKRVIVQ CDK5_activator protein stabilization apoptosis, inhibited; signaling pathway regulation 17121855; 30770557 8 1 0 regulates p35-p25/CDK5 signaling pathway; decreased phosphorylation in adult compared to prenatal brain correlated with lower resistance to calpain cleavage; -EIF2S1 eIF2-alpha RNA-binding; Translation; Translation initiation P05198 1965 14q23.3 human K143-ac 63112800 WVFDDKYkRPGYGAY EIF_2_alpha apoptosis, induced 27911441 1 1 0 -MAPT Tau iso8 ACETYLTRANSFERASE; Acetyltransferase; Cytoskeletal P10636-8 4137 17q21.31 human K311-ub 486345 GSVQIVYkPVDLSKV Tubulin-binding protein stabilization 16443603 1 3 0 -Myh14 MYH14 Motility/polarity/chemotaxis; Motor Q6URW6 71960 7|7 B3 mouse T1960-p 27623909 PLTFTTRtVRQVFRL cytoskeletal reorganization 23426373 1 0 0 Phosphorylation of either residue abolishes filament assembly of MYH14 Rod1296-1854. -Gja4 GJA4 Cell adhesion; Membrane protein, integral; Membrane protein, multi-pass P28235 14612 4 D2.2|4 61.47 cM mouse S328-p 1867850302 SRPNSSAsKKQYV__ protein conformation cell cycle regulation; apoptosis, induced 30736283 1 0 0 -Nkx2-1 NKX2-1 Cell development/differentiation; DNA-binding; Transcription factor P23441 25628 6q23 rat T9-p 451108 SMSPKHTtPFSVSDI transcription, induced 9211870 2 0 0 T9A mutation reduced transactivation of the surfactant B gene promoter -Hist1h2ail1 H3 DNA-binding Q6LED0 291159 17p11 rat K4-m3 1458621 ____ARTkQTARKST Histone chromatin organization, altered; transcription, induced 21779870 178 10 0 -SRSF1 SF2 RNA splicing; RNA-binding; Spliceosome Q07955 6426 17q22 human R93-m1 476743 VEFPRSGrGTGRGGG intracellular localization RNA splicing, induced; RNA stability, inhibited; translation, induced 20308322 1 7 36 prevents SF2 nuclear import and splicing of target genes, and translation is increased in the cytoplasm -SMC3 SMC3 Cell cycle regulation; DNA repair, damage Q9UQE7 9126 10q25.2 human S1083-p 453061 ESERGSGsQSSVPSV SMC_N molecular association, regulation cell cycle regulation; DNA repair, induced DNA(INDUCES) 18442975; 20501661 5 9 3 cohesin binding sites; required for intra-S phase checkpoint -NF2 Merlin Cytoskeletal; Motility/polarity/chemotaxis; Tumor suppressor P35240 4771 22q12.2 human K269-ub 22247412 RNISYSDkEFTIKPL FERM_C molecular association, regulation; intracellular localization LATS1(DISRUPTS) 30918126 1 4 0 K63 kinked -FRS2 FRS2 Adaptor/scaffold Q8WU20 10818 12q15 human Y196-p 448153 AEEQVHTyVNTTGVQ protein degradation; molecular association, regulation cell differentiation, induced; signaling pathway regulation; endocytosis, inhibited SOS1(INDUCES); GRB2(INDUCES) 11278583; 21625213; 36410439 7 3 9 affects KGFR endocytic trafficking and degradation; activates FGFR1 signaling -Gria1 GluR1 Channel, calcium; Channel, ligand-gated; Membrane protein, integral; Membrane protein, multi-pass P19490 50592 10q22 rat K831-ac 206219721 ALIEFCYkSRSESKR protein stabilization; ubiquitination; receptor internalization, inhibited neural plasticity 28793258 1 0 0 inhibits ubiquitination; impaired learning and memory -CCDC124 CCDC124 Cell cycle regulation Q96CT7 115098 19p13.11 human S122-p 27445755 DTAEKAKsHLEVPLE protein stabilization 23894443 1 3 0 -KCNJ1 ROMK Channel, potassium; Membrane protein, integral; Membrane protein, multi-pass P48048 3758 11q24.3 human Y337-p 451246 SKTKEGKyRVDFHNF IRK_C intracellular localization; activity, inhibited 11719519; 12556363; 19706464 4 0 0 -NHERF1 NHERF Adaptor/scaffold; Motility/polarity/chemotaxis O14745 9368 17q25.1 human T95-p 4047202 LLVVDPEtDEQLQKL phosphorylation 20571032 2 0 0 facilitates phosphorylation of S77 -CALM1 Calmodulin Calcium-binding; Protein phosphatase, regulatory subunit P0DP23 801 14q32.11 human S82-p 448705 RKMKDTDsEEEIREA activity, induced; protein conformation 15461451; 17173306; 36273583 9 16 0 induces CaV1.2 activity -NR4A1 Nur77 Apoptosis; DNA-binding; Nuclear receptor P22736 3164 12q13.13 human S140-p 2591500 GSPCSAPsPSTPSFQ molecular association, regulation cell cycle regulation PIN1(INDUCES) 22002310 3 0 0 required for cell proliferation; interaction with Pin1 enhances Nur77 ability to interact with p300 -INPP5D SHIP iso2 EC 3.1.3.86; Motility/polarity/chemotaxis; Phosphatase, lipid Q92835-2 3635 2q37.1 human Y1021-p 448865 EMFENPLyGSLSSFP intracellular localization 29852247 10 15 202 nucleocytoplasmic shuttling (A mutants show accumulation in nucleus) -TP53 p53 Activator; DNA-binding; Motility/polarity/chemotaxis; Nuclear receptor co-regulator; Transcription factor; Tumor suppressor P04637 7157 17p13.1 human K370-m2 2574934 RAHSSHLkSKKGQST molecular association, regulation transcription, induced PHF20(INDUCES); JMJD2A(INDUCES); 53BP1(INDUCES) DNA(INDUCES) 17805299; 19334741; 33961797 2 2 0 -Usp20 USP20 DEUBIQUITINASE; EC 3.4.19.12; Protease; Ubiquitin conjugating system; Ubiquitin-specific protease Q8C6M1 74270 2|2 B mouse S134-p 469014 ADEGESEsEDDDLKP protein stabilization; molecular association, regulation; ubiquitination signaling pathway regulation AMFR(INDUCES) 33177714 1 46 2 inhibits ubiquitination of HMGCR thus stabilizing it, regulates the mTORC1?USP20?HMGCR pathway -DLG1 DLG1 Adaptor/scaffold; Motility/polarity/chemotaxis Q12959 1739 3q29 human S443-p 5931300 FLGQTPAsPARYSPV PDZ_assoc protein degradation; protein stabilization; ubiquitination; intracellular localization 19066288; 19307009 3 2 10 degraded by HPV E6 oncoprotein in HPV-containing cell lines -TP53 p53 Activator; DNA-binding; Motility/polarity/chemotaxis; Nuclear receptor co-regulator; Transcription factor; Tumor suppressor P04637 7157 17p13.1 human S46-p 447536 AMDDLMLsPDDIEQW TAD2 activity, induced; protein degradation; molecular association, regulation; protein stabilization; acetylation; intracellular localization; protein conformation cell cycle regulation; carcinogenesis, induced; apoptosis, altered; carcinogenesis, inhibited; cell growth, inhibited; apoptosis, induced; transcription, induced; transcription, altered; DNA repair, induced; apoptosis, inhibited; transcription, inhibited; cell growth, altered BAX(INDUCES); S100B(INDUCES); TFB1M(INDUCES); SCO2(INDUCES); S100A1(INDUCES); S100A4(INDUCES); PIN1(INDUCES); CBP(INDUCES); PPP1R13L(DISRUPTS); RPA1(INDUCES); GTF2H1(INDUCES); S100A6(INDUCES); GLS2(INDUCES); S100A2(INDUCES) DNA(INDUCES); DNA(DISRUPTS) 10581258; 11030628; 11740489; 11780126; 12093737; 12397361; 15471885; 15526030; 15706352; 15843377; 15897882; 16247456; 16377624; 16738336; 16793543; 17210684; 17349958; 17349959; 17567906; 17906639; 18160537; 18216278; 18769132; 19465479; 19819244; 19828042; 19965871; 20018442; 20024960; 20171273; 20962272; 21057547; 21394211; 21765463; 22011578; 22525275; 22797063; 22878263; 24379358; 24899407; 25915850; 25944899; 26029824; 26236013; 27034505; 27208501; 33443163; 33906076; 34103685; 34980600; 35227287 115 3 0 -RAD52 RAD52 DNA repair, damage P43351 5893 12p13.33 human K411-sm 13258714 HRKSQDMkKRKYDPS intracellular localization 20190268 1 1 0 -Sqstm1 SQSTM1 Autophagy; Nuclear receptor co-regulator; Ubiquitin conjugating system O08623 113894 10q22 rat S293-p 31872178 SSCSSEVsKPDGAGE intracellular localization autophagy, induced 28655770 1 2 0 localization in mitochondria -F2RL1 F2RL1 GPCR, family 1; Membrane protein, integral; Membrane protein, multi-pass; Receptor, GPCR P55085 2150 5q13.3 human S383-p 25291197 SKKHSRKsSSYSSSS receptor desensitization, induced; molecular association, regulation; phosphorylation signaling pathway regulation ARRB1(INDUCES); ARRB2(INDUCES) 33073187 1 0 1 inhibits ERK phosphorylation and signaling; regulates calcium signaling -Ulk1 ULK1 Autophagy; EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, Other; Protein kinase, Ser/Thr (non-receptor) O70405 22241 5|5 F mouse S774-p 4699305 STRTRMFsVGSSSSL signaling pathway regulation 21819378 1 4 2 signaling for autophagy regulation -Fgfr1 FGFR1 EC 2.7.10.1; KINASE; Kinase, protein; Membrane protein, integral; Oncoprotein; Protein kinase, TK; Protein kinase, tyrosine (receptor) P16092 14182 8 A2|8 14.12 cM mouse Y766-p 447922 ALTSNQEyLDLSIPL molecular association, regulation cell cycle regulation; transcription, altered; cell growth, altered SHB(INDUCES) 12181353; 9694798 10 1 0 Y766F mutation causes embryonic transformations in vertebral column. -PRKDC DNAPK DNA repair, damage; EC 2.7.11.1; KINASE; Kinase, protein; Nucleolus; Protein kinase, Ser/Thr (non-receptor); Protein kinase, atypical P78527 5591 8q11.21 human S2029-p 33365501 PSYMSSLsYLADSTL DNAPKcs_CC3 molecular association, regulation DNA repair, inhibited DNA(INDUCES) 24687855 1 0 0 induces c-NHEJ, restricts end processing -MAPT Tau iso8 ACETYLTRANSFERASE; Acetyltransferase; Cytoskeletal P10636-8 4137 17q21.31 human S320-p 450139 VDLSKVTsKCGSLGN Tubulin-binding protein stabilization cytoskeletal reorganization 10090741; 15652175 4 0 0 promotes stability of helix structure and microtubule polymerization in vitro. -AKT1 Akt1 EC 2.7.11.1; KINASE; Kinase, protein; Oncoprotein; Protein kinase, AGC; Protein kinase, Ser/Thr (non-receptor) P31749 207 14q32.33 human S124-p 450018 EMDFRSGsPSDNSGA enzymatic activity, induced carcinogenesis, induced 36114575; 9690513 5 29 0 -C2orf88 smAKAP Q9BSF0 84281 2q32.2 human S66-p 54468602 LEYAHRLsQDILCDA SmAKAP molecular association, regulation; protein conformation PKACA(DISRUPTS) 27028580 1 1 0 -NKAP NKAP Unknown function Q8N5F7 79576 Xq24 human S9-p 14576893 APVSGSRsPDREASG intracellular localization transcription, induced; signaling pathway regulation 31461649 1 16 1 enhances NF-KB nuclear localization, regulates PTEN/NKAP/NF-KB/PDHK1 signaling -FANCD2 FANCD2 DNA repair, damage Q9BXW9 2177 3p25.3 human S717-p 453231 KDGGPVTsQESGQKL FancD2 activity, induced cell cycle regulation 16943440 1 8 0 promotes monoubiquitination of FANCD2 -E2F1 E2F1 DNA-binding; Transcription factor Q01094 1869 20q11.22 human R111-me 57676507 SSGPARGrGRHPGKG protein degradation; molecular association, regulation; ubiquitination; methylation cell cycle regulation; carcinogenesis, induced; cell growth, induced; apoptosis, inhibited; transcription, inhibited TSN(INDUCES) DNA(DISRUPTS) 22327218; 24076217 2 1 0 inhibits asymmetrical methylation. Binding to TSN regulates binding of TSN to DNA -POLI POLI DNA repair, damage; EC 2.7.7.7; Transferase Q9UNA4 11201 18q21.2 human K574-ub 50771306 GVLSFFSkKQMQDIP protein degradation 26370087 1 1 0 -PXN PXN Adaptor/scaffold; Cell adhesion; Cytoskeletal; Motility/polarity/chemotaxis P49024 395832 chicken S457-p 448768 AILENYIsALNTLWH LIM intracellular localization 9658172 1 0 0 -Nos3 eNOS Amino Acid Metabolism - arginine and proline; EC 1.14.13.39; Oxidoreductase P70313 18127 5 A3|5 11.32 cM mouse S1178-p 467802 RIRTQSFsLQERQLR intracellular localization 17982133 11 8 1 S1177 appears in cell membranes and perinuclear golgi and significant difference of protein expression between the LC and GC regions of aorta ascending archplate. -MRPS23 MRPS23 Mitochondrial; Ribosomal; Translation Q9Y3D9 51649 17q22 human K108-m2 1881582601 EKYTELQkLGETDEE protein degradation; ubiquitination cell motility, induced 33927350 1 0 0 promote degradation to a low level -Cebpa C/EBP-alpha DNA-binding; Transcription factor P05554 24252 1q21 rat S230-p 447618 PPPTPVPsPHPAPAM activity, inhibited transcription, altered 16600022 4 0 0 In 3T3L1 preadipocytes, mutation of T222/T226 to alanines increased transcription at CBE-containing promoter (as compared to WT C/EBP-alpha). S230A had a similar effect as the double T->A mutation. The triple alanine mutation had the highest transcription of the reporter gene. S230A did not reduce T222/226 phosphorylation (although CHIR99021 inhibitor did). -PPP1R14A PPP1R14A Inhibitor; Protein phosphatase, regulatory subunit Q96A00 94274 19q13.2 human T38-p 449098 QKRHARVtVKYDRRE PP1_inhibitor receptor desensitization, altered; activity, inhibited cell motility, altered 12144526; 12495628 29 0 0 inhibition of MLCP activity, activates contractile response in arterial smooth muscle; Phosphorylation at T38-CPI-17 was required for induction of cerebellar long-term synaptic depression -Hsf1 HSF1 iso2 DNA-binding; Transcription factor P38532-2 15499 15 D3|15 35.95 cM mouse S326-p 455484 SSMDTPLsPTAFIDS Vert_HS_TF carcinogenesis, induced; cell growth, induced 35906200 48 25 13 -AGAP2 CENTG1 iso2 GAP; GAP, ARF; Motility/polarity/chemotaxis; Tumor suppressor Q99490-2 116986 12q14.1 human Y682-p 467224 ESWIRAKyEQLLFLA ArfGap molecular association, regulation; protein stabilization apoptosis, altered; cell growth, induced AMPKA2(INDUCES) 16841086; 26001218 2 0 0 -ELP1 IKBKAP Protein kinase, regulatory subunit; Transcription regulation O95163 8518 9q31.3 human S1174-p 3178326 SETSSVVsGSEMSGK activity, induced 29925953 1 2 0 regulates elongator activity, cell survival induced -Irf6 IRF6 DNA-binding; Transcription factor P97431 54139 1 H6|1 97.6 cM mouse S90-p 56649936 LRCALNKsREFNLMY IRF activity, induced cell differentiation, induced; transcription, induced 31578523 1 2 0 -RBBP8 CtIP EC 3.1.-.-; Transcription, coactivator/corepressor Q99708 5932 18q11.2 human K515-ac 33625701 GSETSKNkFRQVTLY enzymatic activity, induced 24837676 1 1 0 -NUAK1 NuaK1 EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, CAMK; Protein kinase, Ser/Thr (non-receptor) O60285 9891 12q23.3 human T211-p 456032 QKDKFLQtFCGSPLY Pkinase enzymatic activity, induced cell cycle regulation; cell growth, inhibited; cell growth, altered 16488889; 19927127; 21317932 5 1 1 -NAA10 NAA10 ACETYLTRANSFERASE; Acetyltransferase; Amino Acid Metabolism - phenylalanine; Amino Acid Metabolism - tyrosine; EC 2.3.1.88; Lipid Metabolism - glycerophospholipid; Secondary Metabolites Metabolism - limonene and pinene degradation P41227 8260 Xq28 human S228-p 3190219 STDVKDSsEASDSAS phosphorylation autophagy, inhibited PGK1(DISRUPTS) 28238651 1 7 2 inhibits Beclin1 phosphorylation -ATRIP ATRIP Cell cycle regulation; DNA repair, damage; DNA-binding Q8WXE1 84126 3p21.31 human S224-p 485778 APSVSHVsPRKNPSV cell cycle regulation 17638878 1 38 5 important for the G2-M checkpoint arrest in response to DNA damage -Cdc25b CDC25B EC 3.1.3.48; Motility/polarity/chemotaxis; Nuclear receptor co-regulator; PHOSPHATASE; Protein phosphatase, dual-specificity P30306 12531 2 F1|2 63.29 cM mouse S321-p 448409 QRLFRSPsMPCSVIR M-inducer_phosp intracellular localization; phosphorylation cell cycle regulation 18633139; 21212267; 22348958 13 9 30 -Rcan1 RCAN1 Inhibitor Q9JHG6 54720 16 C4|16 53.6 cM mouse T177-p 8142805 WKQVEDAtPVINYDL Calcipressin molecular association, regulation PPP3CA(DISRUPTS) 22864830 2 1 6 -F2RL1 F2RL1 GPCR, family 1; Membrane protein, integral; Membrane protein, multi-pass; Receptor, GPCR P55085 2150 5q13.3 human T391-p 12184123 SSYSSSStTVKTSY_ receptor desensitization, induced; molecular association, regulation; phosphorylation signaling pathway regulation ARRB1(INDUCES); ARRB2(INDUCES) 33073187 1 0 1 inhibits ERK phosphorylation and signaling; regulates calcium signaling -PRKCD PKCD EC 2.7.11.13; KINASE; Kinase, protein; Nuclear receptor co-regulator; Protein kinase, AGC; Protein kinase, Ser/Thr (non-receptor); Protein kinase, tyrosine (non-receptor); Tumor suppressor Q05655 5580 3p21.1 human K475-sm 1881459303 GIIYRDLkLDNVLLD sumoylation; protein stabilization apoptosis, induced 34089566 1 0 0 promotes apoptosis induced by H2O2; phosphorylation induces sumoylation which reciprocally induces phosphorylation -H4C1 H4 DNA-binding P62805 8359 6p22.2 human K5-ac 458958 ___SGRGkGGKGLGK protein stabilization; acetylation; molecular association, regulation cell cycle regulation; cell growth, inhibited; transcription, induced; transcription, altered; DNA repair, induced; chromatin organization, altered; cell differentiation, induced; cell growth, induced TBN(INDUCES); BRDT(INDUCES); CGI-09(INDUCES); PUS1(INDUCES); SETD8(DISRUPTS); THOC4(INDUCES); TAF4(INDUCES); BRD4(INDUCES); BRD2(INDUCES) DNA(DISRUPTS) 18179771; 18418072; 18628788; 18985155; 19805290; 19828451; 20043883; 20709061; 20720004; 21047799; 21726812; 23653357; 23970329; 31881804; 35876654; 36961817 72 22 516 decline of histone marks was more notable in H4K5ac and H4K12ac; LINC00839 promotes oxidative phosphorylation (OXPHOS), mitochondrial biogenesis and CRC progression -STAT3 STAT3 DNA-binding; Motility/polarity/chemotaxis; Nuclear receptor co-regulator; Transcription factor P40763 6774 17q21.2 human K87-ac 461011 QHNLRRIkQFLQSRY STAT_int activity, induced; molecular association, regulation; intracellular localization transcription, induced p300(INDUCES) 16285960; 18782771 4 1 0 affects nuclear-cytoplasmic redistribution of the protein; induces enhanceosome formation -NEDD1 NEDD1 Cell cycle regulation Q8NHV4 121441 12q23.1 human S426-p 9379002 VNKGSDEsIGKGDGF molecular association, regulation cell cycle regulation 19509060 2 3 0 important for binding of NEDD1 with gamma-tubulin -KRT18 K18 Cytoskeletal; Nucleolus P05783 3875 12q13.13 human S49-gl 6778603 SGSRISVsRSTSFRG phosphorylation apoptosis, inhibited 20729838 3 0 0 K18?Gly? mutation alters protein kinase phosphorylation and promotes apoptosis in response to STZ treatment; Akt1 Thr 308 phosphorylation increased 12 h after STZ treatment in livers of mice expressing wild-type K18, but in K18?Gly? inhibits Akt1 Thr 308 phosphorylation; glycosylation promotes th the phosphorylation and activation of cell-survival kinases -KIF14 KIF14 Microtubule-binding; Motor Q15058 9928 1q32.1 human S607-p 114810406 NLIDLAGsERCSTAH Kinesin intracellular localization 28630147 1 0 0 spindle localization of Kif14 in anaphase -PFKM PFKM Carbohydrate Metabolism - fructose and mannose; Carbohydrate Metabolism - galactose; Carbohydrate Metabolism - glycolysis and gluconeogenesis; Carbohydrate Metabolism - pentose phosphate pathway; EC 2.7.1.11; Kinase, other P08237 5213 12q13.11 human S762-p 55569802 YEIDLDTsDHAHLEH enzymatic activity, inhibited 27153534 1 2 0 -Wnk4 WNK4 EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, Other; Protein kinase, Ser/Thr (non-receptor) Q80UE6 69847 11|11 D mouse K390-ub 40323306 RKVTSGTkPNSFYKV Pkinase protein degradation 23576762 1 1 0 regulates electrolyte homeostasis and involved in Pseudohypoaldosteronism type II (PHAII) pathogenesis -RUNX1 AML1 iso8 DNA-binding; Oncoprotein; Transcription factor Q01196-8 861 21q22.12 human R237-me 2363102 QLRRTAMrVSPHHPA apoptosis, induced; transcription, induced 32573733 2 1 0 -BBOX1 BBOX1 Amino Acid Metabolism - lysine degradation; EC 1.14.11.1; Oxidoreductase O75936 8424 11p14.2 human K240-ub 27179485 DGFNVCQkLKKNNPQ TauD protein degradation carcinogenesis, induced 35775648 1 2 0 promotes CRIP1-induced cancer stem-like properties in HCC -SLBP SLBP RNA-binding Q14493 7884 4p16.3 human T171-p 11003653 QPGIHPKtPNKFKKY SLBP_RNA_bind molecular association, regulation; intracellular localization; protein conformation SLBP(DISRUPTS); PIN1(INDUCES) RNA(INDUCES) 16492733; 22907757; 23286197; 25002523 3 10 28 crystal structure of human T171 phosphorylated SLBP -HDAC4 HDAC4 DEACETYLASE; Deacetylase; EC 3.5.1.98; Hydrolase; Nuclear receptor co-regulator; SUMO LIGASE P56524 9759 2q37.3 human S265-p 4737971 QKVAERRsSPLLRRK activity, induced; intracellular localization transcription, inhibited 23652597; 29472387; 30661366 4 15 0 transcription of MEF2 target genes RhoB and Klf2 -SP1 SP1 C2H2-type zinc finger protein; DNA-binding; Transcription factor P08047 6667 12q13.13 human S7-p 2535902 _MSDQDHsMDEMTAV protein degradation 18239466 1 23 0 -BECN1 beclin 1 Adaptor/scaffold; Autophagy; Membrane protein, peripheral Q14457 8678 17q21.31 human S30-p 7446159 QPLKLDTsFKILDRV protein conformation; enzymatic activity, induced carcinogenesis, induced; autophagy, induced; cell growth, induced 26118643; 28238651; 29313410 5 6 0 induces activity of the PIK3C3 complex -EGFR EGFR EC 2.7.10.1; KINASE; Kinase, protein; Membrane protein, integral; Oncoprotein; Protein kinase, TK; Protein kinase, tyrosine (receptor) P00533 1956 7p11.2 human K728-ub 1065316 GAFGTVYkGLWIPEG PK_Tyr_Ser-Thr protein degradation 17940017 1 3 0 -SIRT2 SIRT2 DEACETYLASE; Deacetylase; EC 3.5.1.- Q8IXJ6 22933 19q13.2 human Y104-p 479395 RSPSTGLyDNLEKYH SIR2 protein degradation apoptosis, induced; transcription, inhibited 24996174 1 0 3 transcription of p53 was attenuated; SIRT2 levels and stability decreases after phosphorylation; apoptosis augmented by c-Src SIRT2 downregulation -NF2 Merlin Cytoskeletal; Motility/polarity/chemotaxis; Tumor suppressor P35240 4771 22q12.2 human K396-ub 12104551 QITEEEAkLLAQKAA ERM_helical molecular association, regulation; intracellular localization; phosphorylation carcinogenesis, inhibited; cell growth, inhibited; transcription, inhibited; signaling pathway regulation LATS1(DISRUPTS); LATS1(INDUCES) 30918126; 33058421 2 10 3 induces Hippo pathway, induces LATS1/YAP/TAZ phosphorylation; K63 kinked -Slc12a5 KCC2 Membrane protein, integral; Membrane protein, multi-pass; Transporter; Transporter, SLC family Q91V14 57138 2|2 H3 mouse Y1109-p 3087801 NRNGDENyMEFLEVL SLC12 protein degradation 20600929 3 0 0 decreases the cell surface stability of SLC12A5 (aka KCC2) -Ulk1 ULK1 Autophagy; EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, Other; Protein kinase, Ser/Thr (non-receptor) O70405 22241 5|5 F mouse T653-p 23070978 ARQGVVMtPPRNRTL cell cycle regulation; autophagy, induced; cell growth, induced 32516310 1 2 1 -L3MBTL2 L3MBTL2 Histone-binding Q969R5 83746 22q13.2 human S335-p 1046182902 RLEVVDKsQVSRTRM MBT molecular association, regulation; intracellular localization MDC1(INDUCES) 29581593 1 0 0 -CNKSR1 CNK1 Adaptor/scaffold; G protein regulator, misc. Q969H4 10256 1p36.11 human K414-ac 206219717 DGWLLLRkAPGGFMG PH molecular association, regulation; intracellular localization; phosphorylation cell motility, induced; cell growth, induced; signaling pathway regulation RAF1(INDUCES) 28819643 1 0 0 ERK phosphorylation. Stimulates RAF/MEK/ERK pathway and mediates oncogenic RAS signaling -MTURN MTURN Q8N3F0 222166 7p14.3 human S58-p 149319100 GDNFHVWsESEDCLP DUF4581 molecular association, regulation transcription, induced IKKA(DISRUPTS); IKKB(DISRUPTS) 28704656 1 0 0 loss of the ability to inhibit virus-triggered signaling -PPP1R16B PPP1R16B Motility/polarity/chemotaxis; Protein phosphatase, regulatory subunit Q96T49 26051 20q11.23 human S337-p 486245 SSLSRRTsSAGSRGK phosphorylation 31315927 2 0 0 increases phosphorylation of MLC2 -NSF NSF Adaptor/scaffold; Autophagy; EC 3.6.4.6; Protease; Vesicle P46459 4905 17q21.31 human T645-p 53340201 RKLLIIGtTSRKDVL AAA enzymatic activity, induced 26758690 1 1 0 increases NSF ATPase activity, increases the rate of SNARE complex disassembling -Mark2 MARK2 EC 2.7.11.1; EC 2.7.11.26; KINASE; Kinase, protein; Protein kinase, CAMK; Protein kinase, Ser/Thr (non-receptor) O08679 60328 1q43 rat S92-p 26573804 DKTQLNSsSLQKLFR Pkinase cytoskeletal reorganization 17442826 1 0 0 neurite outgrowth -CALD1 Caldesmon Actin-binding P12957 373965 chicken S635-p 457432 AVVSKIDsRLEQYTS Caldesmon molecular association, regulation Caldesmon(DISRUPTS) 20858431 1 6 0 enhances effect of S672 and S702 phosphorylation to weaken interaction -ITGB1 ITGB1 Cell adhesion; Cell surface; Membrane protein, integral; Motility/polarity/chemotaxis; Receptor, misc. P07228 374058 chicken S790-p 452040 GENPIYKsAVTTVVN Integrin_b_cyt cell motility, altered; cell adhesion, altered 11559760 5 11 17 -GIT2 GIT2 GAP; GAP, ARF; Motility/polarity/chemotaxis Q9Y621 374035 chicken Y286-p 456753 EELAMYVyDEVDRRE GIT_SHD molecular association, regulation; intracellular localization cell adhesion, altered PXN(INDUCES) 16000375 1 0 0 -Trpv1 TRPV1 Channel, cation; Membrane protein, integral; Membrane protein, multi-pass; Receptor, misc. O35433 83810 10q24 rat T704-p 487542 WKLQRAItILDTEKS activity, induced; receptor desensitization, altered RNUXA(INDUCES) 14523239; 14630912; 17869438; 33180962 6 0 0 -EPAS1 HIF2A DNA-binding; Transcription factor Q99814 2034 2p21 human S383-p 59087903 SSGKGAVsEKSNFLF intracellular localization transcription, induced 27686097 1 1 0 EPO secretion, inhibits CRM1-dependent nuclear export of HIF2A -Myf6 Myf-6 DNA-binding; Transcription factor P15375 17878 10 D1|10 55.96 cM mouse S31-p 2907504 PLEVAEGsPLYPGSD Basic cell differentiation, altered; transcription, inhibited 14739931 1 0 0 -PDE4C PDE4C iso2 EC 3.1.4.53; Nucleotide Metabolism - purine; Phosphodiesterase Q08493-2 5143 19p13.11 human S13-p 458390 PHSQRREsFLYRSDS enzymatic activity, induced 12023945 1 20 1 -MAP3K7 TAK1 EC 2.7.11.25; KINASE; Kinase, protein; Protein kinase, Ser/Thr (non-receptor); Protein kinase, TKL O43318 6885 6q15 human T184-p 454876 GTACDIQtHMTNNKG PK_Tyr_Ser-Thr phosphorylation; enzymatic activity, induced signaling pathway regulation 10838074; 18617512; 19223549; 20538596; 31387937; 31511642; 36270986 20 0 0 induces TAK1-ADAM17 signaling; induces MAPK and NF-kB signaling pathways by inducing phosphorylation of JNK and ERK -Creb1 CREB iso1 DNA-binding; Transcription factor P15337-1 81646 9q32 rat S114-p 451809 ESEDSQEsVDSVTDS pKID transcription, altered 9931297 8 1 1 -SH3GL2 endophilin A1 Adaptor/scaffold; Membrane protein, peripheral; Vesicle Q99962 6456 9p22.2 human T14-p 457634 KKQFHKAtQKVSEKV BAR molecular association, regulation SH3KBP1(DISRUPTS) 16164598 1 0 0 -Sstr3 SSTR3 GPCR, family 1; Membrane protein, integral; Membrane protein, multi-pass; Receptor, GPCR P30935 20607 15 E1|15 37.55 cM mouse T357-p 456711 GSGPPEKtEEEEDEE intracellular localization 26503786 2 0 0 SST binds to SSTR3 3 on the ciliary membrane and may lead to phosphorylation of residue T357, which facilitates ?-arrestin 2 ciliary localization -DRD2 DRD2 GPCR, family 1; Membrane protein, integral; Membrane protein, multi-pass; Receptor, GPCR P14416 1813 11q23.2 human K226-ub 1877221607 RRKRVNTkRSSRAFR 7tm_1 protein degradation 32572597 1 0 0 -HADHA HADHA ACETYLTRANSFERASE; Acetyltransferase; Amino Acid Metabolism - lysine degradation; Amino Acid Metabolism - tryptophan; Amino Acid Metabolism - valine, leucine and isoleucine degradation; Carbohydrate Metabolism - butanoate; Carbohydrate Metabolism - propanoate; EC 1.1.1.211; EC 4.2.1.17; Lipid Metabolism - fatty acid; Lipid Metabolism - fatty acid elongation in mitochondria; Lipid Metabolism - unsaturated fatty acid biosynthesis; Lyase; Mitochondrial; Other Amino Acids Metabolism - beta-alanine; Oxidoreductase; Secondary Metabolites Metabolism - limonene and pinene degradation P40939 3030 2p23.3 human K350-ub 27192507 YHGQVLCkKNKFGAP protein degradation; ubiquitination 27457618 1 1 0 -MYL2 MRLC2V Contractile P10916 4633 12q24.11 human Y118-p 473229 KGVLKADyVREMLTT molecular association, regulation; phosphorylation cell cycle regulation; carcinogenesis, induced; cell growth, induced ROCK2(INDUCES) 25412762 1 4 128 induces phosphorylation at S15, regulates cytokinesis -HDAC4 HDAC4 DEACETYLASE; Deacetylase; EC 3.5.1.98; Hydrolase; Nuclear receptor co-regulator; SUMO LIGASE P56524 9759 2q37.3 human S467-p 448489 RPLGRTQsAPLPQNA molecular association, regulation; intracellular localization cell cycle regulation; carcinogenesis, induced; apoptosis, inhibited; transcription, induced; transcription, altered 14-3-3 beta(INDUCES); LATS2(DISRUPTS); 14-3-3 epsilon(INDUCES); YAP1(INDUCES) 10869435; 10958686; 35780183 7 18 23 -Il1a IL1A Cytokine; Motility/polarity/chemotaxis P01582 16175 2 F1|2 62.9 cM mouse S90-p 451281 ILKKRRLsFSETFTE IL1_propep molecular association, regulation PLD6(INDUCES) 33361152 2 1 0 -CNN1 calponin 1 Actin-binding; Contractile; Motility/polarity/chemotaxis; Myosin-binding P26932 396522 chicken T259-p 469596 GASQQGMtVYGLPRQ Calponin molecular association, regulation ACTA1(DISRUPTS) 10873572 1 1 1 f-actin (rabbit skeletal muscle) shown by co-sedimentation -FBF1 FBF1 Q8TES7 85302 17q25.1 human S334-p 27449008 QSPPMASsPIQPRKG molecular association, regulation cell cycle regulation PLK1(INDUCES) 30318703 1 4 0 centrosome seperation -PTK2 FAK EC 2.7.10.2; KINASE; Kinase, protein; Protein kinase, TK; Protein kinase, tyrosine (non-receptor) Q05397 5747 8q24.3 human S695-p 25291278 EERMRMEsRRQATVS phosphorylation; enzymatic activity, induced cell motility, induced; cell adhesion, inhibited 23264741 1 0 1 induces phosphorylation at T700 -H4C1 H4 DNA-binding P62805 8359 6p22.2 human Y88-p 457867 VTAMDVVyALKRQGR CENP-T_C cell growth, induced; transcription, induced; translation, induced 28609657 3 28 1036 ACK kinase activity drives AR Eepression in an androgen-deficient environment -TH TH iso3 Amino Acid Metabolism - tyrosine; EC 1.14.16.2; Endoplasmic reticulum; Mitochondrial; Oxidoreductase; Vesicle P07101-3 7054 11p15.5 human S19-p 448542 KGFRRAVsELDAKQA TOH_N molecular association, regulation; enzymatic activity, induced 14-3-3 zeta(INDUCES); 14-3-3 gamma(INDUCES) 12421349; 19801645; 24947669; 33456492 46 9 4 -SMAD4 SMAD4 DNA-binding; Nuclear receptor co-regulator; Transcription, coactivator/corepressor Q13485 4089 18q21.2 human T277-p 449628 GSRTAPYtPNLPHHQ activity, induced; molecular association, regulation; intracellular localization; phosphorylation transcription, induced TIF1A(DISRUPTS); USP9X(INDUCES) 25373906; 28115363 3 0 0 a priming site for T269, T265 and T273 phosphorylations -Ankrd2 ANKRD2 Contractile Q9WV06 56642 19|19 C3 mouse S68-p 480101 QERVRKTsLDLRREI cell differentiation, inhibited 21737686 2 6 8 inhibits muscle differentiation -CD93 CD93 Cell adhesion; Membrane protein, integral Q9NPY3 22918 20p11.21 human Y644-p 463128 SRAMENQySPTPGTD molecular association, regulation cell motility, induced; cell adhesion, induced CBL(INDUCES) 26848865 1 4 21 CD93 binds to Cbl inducing phosphorylation on tyrosine 774 of CBL -BRCA1 BRCA1 EC 6.3.2.-; Nuclear receptor co-regulator; Transcription, coactivator/corepressor; Tumor suppressor; UBIQUITIN LIGASE; Ubiquitin conjugating system; Ubiquitin ligase P38398 672 17q21.31 human S1524-p 448038 LQNRNYPsQEELIKV molecular association, regulation; ubiquitination; phosphorylation cell cycle regulation; carcinogenesis, induced; DNA repair, induced; DNA repair, altered; transcription, induced ATM(INDUCES); claspin(INDUCES) 10550055; 12183412; 15096610; 15159397; 26320175; 33568520; 34610268 15 18 2 inhibits TOP2B ubiquitination -SKP2 SKP2 Cell cycle regulation; UBIQUITIN LIGASE; Ubiquitin conjugating system; Ubiquitin ligase Q13309 6502 5p13.2 human T417-p 15165300 WGIKCRLtLQKPSCL activity, induced; protein stabilization; ubiquitination cell cycle regulation 20663873 1 0 0 -ERBB3 HER3 EC 2.7.10.1; KINASE; Kinase, protein; Membrane protein, integral; Oncoprotein; Protein kinase, TK; Protein kinase, tyrosine (receptor) P21860 2065 12q13.2 human Y1197-p 448640 EEDEDEEyEYMNRRR molecular association, regulation; enzymatic activity, induced carcinogenesis, induced; cell growth, induced; cell motility, induced; apoptosis, inhibited; signaling pathway regulation GRB2(INDUCES); GRB7(INDUCES); PIK3R2(INDUCES); PIK3R1(INDUCES) 16729043; 21725367; 34320350; 9516479 7 3 24 Grb2 binding is reduced campared with Grb7.; induces ERBB3/PI3K/mTOR pathway; chemotaxis and invasion -CSNK1E CK1E EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, CK1; Protein kinase, Ser/Thr (non-receptor) P49674 1454 22q13.1 human S408-p 453421 RIPASQTsVPFDHLG enzymatic activity, inhibited 10542239; 12223474 2 14 10 some subset of these 8 sites -CDC6 CDC6 Cell cycle regulation Q99741 990 17q21.2 human T37-p 17481900 SDAKLEPtNVQTVTC molecular association, regulation cell cycle regulation CDK1(INDUCES) 21041660 1 0 0 -WASF2 WAVE2 Actin-binding; Motility/polarity/chemotaxis Q9Y6W5 10163 1p36.11 human S484-p 6377638 IAVEYSDsEDDSSEF activity, inhibited cytoskeletal reorganization 19012317 1 0 1 -PTPN3 PTPN3 EC 3.1.3.48; Motility/polarity/chemotaxis; PHOSPHATASE; Protein phosphatase, tyrosine (non-receptor) P26045 5774 9q31.3 human S459-p 25594501 QKSSSSVsPSSNAPG protein stabilization; enzymatic activity, induced carcinogenesis, induced; cell growth, induced; apoptosis, inhibited 22730326; 26079946 2 1 0 -YY1 YY1 C2H2-type zinc finger protein; Cell development/differentiation; Transcription factor P25490 7528 14q32.2 human Y383-p 41608702 IHTGDRPyVCPFDGC zf-C2H2 activity, inhibited transcription, inhibited DNA(DISRUPTS); RNA(DISRUPTS) 26198631 1 0 0 4-5 fold decrease in c-fos mRNA -Syk Syk EC 2.7.10.2; KINASE; Kinase, protein; Protein kinase, TK; Protein kinase, tyrosine (non-receptor) P48025 20963 13 A5|13 27.41 cM mouse S291-p 1983707 ISRIKSYsFPKPGHK molecular association, regulation PHB(INDUCES) 20956537 4 11 23 -PGK1 PGK1 Carbohydrate Metabolism - glycolysis and gluconeogenesis; EC 2.7.2.3; KINASE; Kinase, other P00558 5230 Xq21.1 human K388-ac 33346909 AKWNTEDkVSHVSTG PGK molecular association, regulation carcinogenesis, induced; autophagy, induced; cell growth, induced beclin 1(INDUCES) 28238651 1 4 0 -FADD FADD Adaptor/scaffold; Apoptosis Q13158 8772 11q13.3 human K125-sm 62489901 QLKVSDTkIDSIEDR Death molecular association, regulation; intracellular localization CASP10(INDUCES); DRP1(INDUCES) 27799292 1 0 0 -PDS5A SCC-112 Cell cycle regulation Q29RF7 23244 4p14 human S1278-p 3965429 GRRPKSEsQGNATKN cell cycle regulation; chromatin organization, altered 36469004 1 2 12 -NCOR1 N-CoR1 Nuclear receptor co-regulator; Transcription, coactivator/corepressor O75376 9611 17p12-p11.2 human S70-p 3828921 QQLRRRPsLLSEFHP intracellular localization transcription, inhibited AR(INDUCES) 23129261 1 12 79 increases nuclear translocation, inhibits transcription of PSA and NKX3.1 -BRD7 BRD7 Cell cycle regulation; Histone-binding; Transcription regulation; Tumor suppressor Q9NPI1 29117 16q12.1 human K182-ub 964501744 PMDFSTMkEKIKNND Bromodomain protein degradation cell motility, induced; cell growth, inhibited USP24(INDUCES) 33257797 1 1 0 -POLR2M GRINL1A Channel, ligand-gated; Nuclear envelope; Transferase P0CAP2 81488 15q21.3 human S270-p 3209253 SHCQKSGsPISSEER molecular association, regulation transcription, altered POLR2A(DISRUPTS) 24634214 1 14 0 Phosphorylated Gdown1 inhibited TTF2 and TFIIF -NFATC1 NFAT2 DNA-binding; Transcription factor O95644 4772 18q23 human S151-p 56629000 VLPSSKRsPSTATLS activity, induced carcinogenesis, induced; cell motility, induced; transcription, induced 31730483 2 2 0 multiple sites mutatnt -Gphn gephyrin Adaptor/scaffold; EC 2.10.1.1; EC 2.7.7.75 Q8BUV3 268566 12|12 C3 mouse S268-p 483463 ASLSTTPsESPRAQA receptor internalization, induced; protein degradation neural plasticity 35245123 5 6 2 induces GABAAR internalization -Chpt1 CHPT1 EC 2.7.8.2; Lipid Metabolism - ether lipid; Lipid Metabolism - glycerophospholipid; Membrane protein, integral; Membrane protein, multi-pass; Transferase Q8C025 212862 10|10 C1 mouse K311-ub 12718511 VFAKVAQkLVIAHMT TM protein degradation; enzymatic activity, inhibited 20018880 1 0 0 -TGIF2 TGIF2 DNA-binding Q9GZN2 60436 20q11.23 human T182-p 25174052 PTGGLFNtPPPTPPE molecular association, regulation carcinogenesis, induced; cell motility, induced; transcription, altered HDAC1(INDUCES) DNA(INDUCES) 36647029 1 5 0 -NEFL NFL Cytoskeletal P07196 4747 8p21.2 human T21-p 2872004 YKRRYVEtPRVHISS Filament_head molecular association, regulation NFL(DISRUPTS) 16452125 1 1 0 -LMNA lamin A/C Cytoskeletal P02545 4000 1q22 human S403-p 456874 QRSRGRAsSHSSQTQ intracellular localization 7925482 1 29 80 nuclear transport of lamin -Rela NFkB-p65 DNA-binding; Nuclear receptor co-regulator; Transcription factor Q7TQN4 309165 1q43 rat K310-ac 459096 KRTYETFkSIMKKSP molecular association, regulation; intracellular localization transcription, induced DNA(INDUCES) 22044919; 26298192; 31073968 84 5 0 BACE1 protein and its activity was increased and localized in neurites, after exposure to PA; increase in K310 acetylation due to inhibition of SIRT1 -DSN1 DSN1 Cell cycle regulation Q9H410 79980 20q11.23 human S331-p 10800768 SMQQLDPsPARKLLK MIS13 molecular association, regulation SPC25(DISRUPTS); SPBC24(DISRUPTS) 30420662 1 19 1 Fluorescence polarization, decreased affinity of the interaction -Dusp29 DUSP29 EC 3.1.3.16; EC 3.1.3.48; PHOSPHATASE; Protein phosphatase, dual-specificity P0C595 361003 rat T155-p 18122802 MGRSRSAtLVLAYLM DSPc enzymatic activity, inhibited 21199871 1 0 0 -PAK5 PAK5 EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, STE; Protein kinase, Ser/Thr (non-receptor) Q9P286 57144 20p12.2 human S573-p 11327000 HRDIKSDsILLTSDG Pkinase cytoskeletal reorganization 11756552 1 0 0 -GFAP GFAP Cytoskeletal P14136 2670 17q21.31 human S17-p 1868071202 ARRSYVSsGEMMVGG Filament_head protein stabilization 12177195 1 1 0 -RUNX1 AML1 DNA-binding; Oncoprotein; Transcription factor Q01196 861 21q22.12 human K83-ub 41481876 PTHWRCNkTLPIAFK Runt protein degradation; intracellular localization carcinogenesis, inhibited; cell growth, inhibited; transcription, induced; transcription, inhibited DNA(INDUCES) 11830488; 28536267 2 3 0 -NCAPD3 NCAPD3 Cell cycle regulation P42695 23310 11q25 human S1419-p 19009802 AISTPEKsISDVTFG cell cycle regulation 21498573 1 0 0 -OPRL1 KOR-3 GPCR, family 1; Membrane protein, integral; Membrane protein, multi-pass; Receptor, GPCR P41146 4987 20q13.33 human S351-p 1868135701 QVSDRVRsIAKDVAL receptor internalization, induced; receptor desensitization, induced signaling pathway regulation 30914485 2 0 0 -IGFBP3 IGFBP3 Cell development/differentiation; Secreted; Secreted, signal peptide P17936 3486 7p12.3 human S138-p 451462 PPAPGNAsESEEDRS apoptosis, induced 12210764 3 0 0 -PPP2R2B PPP2R2B iso2 Apoptosis; Mitochondrial; Motility/polarity/chemotaxis; Protein phosphatase, regulatory subunit Q00005-2 5521 5q32 human S21-p 25554901 PPNTILSsSCHTEAD intracellular localization; phosphorylation apoptosis, inhibited 22583914 1 0 0 induces phosphorylation of Drp1 and regulates mitochondrial fragmentation and OMM translocation of beta B2 -IRAK1 IRAK1 EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, Ser/Thr (non-receptor); Protein kinase, TKL P51617 3654 Xq28 human S376-p 449756 GSSPSQSsMVARTQT Pkinase enzymatic activity, induced 29208712 2 1 1 -CAP1 CAP1 Actin-binding; Cytoskeletal Q01518 10487 1p34.2 human S310-p 2525971 PKPQTSPsPKRATKK activity, induced carcinogenesis, induced; cell motility, induced; cell growth, induced; cell adhesion, induced; apoptosis, inhibited; transcription, induced; cytoskeletal reorganization 30123351; 30894654; 34636991 5 47 6 -Card11 CARD11 Adaptor/scaffold Q8CIS0 108723 5|5 G2 mouse S567-p 457640 RSRSSIMsITAEPPG enzymatic activity, induced signaling pathway regulation 31391255 5 0 0 antigen receptor signaling -CCAR1 CCAR1 Apoptosis; Nuclear receptor co-regulator; RNA splicing Q8IX12 55749 10q21.3 human T667-p 4759590 SQLIARLtKQLKVEE SAP molecular association, regulation cell growth, inhibited; apoptosis, induced TAZ(INDUCES) 20594350 1 1 0 -UPF1 RENT1 iso2 C2H2-type zinc finger protein; EC 3.6.1.-; EC 3.6.4.-; Hydrolase; RNA-binding Q92900-2 5976 19p13.11 human S1116-p 460825 HGGVTGLsQY_____ molecular association, regulation RNA(INDUCES) 25184677 3 31 51 marker for cellular NMD targets -NTRK3 TrkC EC 2.7.10.1; KINASE; Kinase, protein; Membrane protein, integral; Protein kinase, TK; Protein kinase, tyrosine (receptor) Q16288 4916 15q25.3 human Y516-p 450003 PVIENPQyFRQGHNC cell growth, altered 11877382 2 5 66 -Slc4a4 SLC4A4 Membrane protein, integral; Membrane protein, multi-pass; Transporter; Transporter, SLC family O88343 54403 5|5 E1 mouse S245-p 2047937 FSNPDNGsPAMTHRN Band_3_cyto activity, inhibited 34642952 1 25 25 -SPRY2 SPRY2 Adaptor/scaffold; Inhibitor; Motility/polarity/chemotaxis O43597 10253 13q31.1 human Y227-p 455228 CCVKGLFyHCSNDDE Sprouty activity, inhibited; phosphorylation transcription, altered 15637081 1 0 0 -PLIN1 perilipin 1 Lipid-binding O60240 5346 15q26.1 human S497-p 459628 EKPKRRVsDSFFRPS intracellular localization 29688805 12 12 0 adrenergic control of lipolysis ; OPA1 is indispensable for HSL translocation to LDs and its phosphorylation on S650 and S552 -Mknk2 Mnk2 EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, CAMK; Protein kinase, Ser/Thr (non-receptor); Translation Q8CDB0 17347 10|10 C1 mouse T249-p 447641 ISTPELLtPCGSAEY Pkinase enzymatic activity, induced 11154262 1 1 0 -SLC9A5 NHE5 Membrane protein, integral; Membrane protein, multi-pass; Transporter; Transporter, SLC family Q14940 6553 16q22.1 human S575-p 34424900 VTNLLREsGSGACLD activity, induced; intracellular localization 24936055 1 0 0 accumulation at the cell surface to regulate cytoplasmic pH; metabolic stress-induced activation -BRCA1 BRCA1 EC 6.3.2.-; Nuclear receptor co-regulator; Transcription, coactivator/corepressor; Tumor suppressor; UBIQUITIN LIGASE; Ubiquitin conjugating system; Ubiquitin ligase P38398 672 17q21.31 human S988-p 448526 PPLFPIKsFVKTKCK activity, induced; intracellular localization carcinogenesis, induced; DNA repair, induced; apoptosis, inhibited 10724175; 12427729; 14701743; 18987440; 33397362 10 0 0 -Max MAX DNA-binding; Transcription factor P52164 60661 6q24 rat S11-p 449308 NDDIEVEsDEEQPRF molecular association, regulation DNA(NOT_REPORTED) 8247525 5 28 0 increases both the on- and off-rates for DNA binding -EML4 EML4 Cytoskeletal Q9HC35 27436 2p21 human S144-p 465781 QSPQIRAsPSPQPSS molecular association, regulation cell cycle regulation; cytoskeletal reorganization TUBB1(INDUCES); TUBA1A(INDUCES) 31409757 1 52 9 -Cycs CYCS Apoptosis; Mitochondrial; Oxidoreductase; PHOSPHATASE; Protein phosphatase, Ser/Thr (non-receptor) P62898 25309 4q24 rat T59-p 36622721 ANKNKGItWGEDTLM Cytochrom_C protein conformation apoptosis, inhibited 31676852 1 4 0 -Gabrg2 GABRG2 Channel, chloride; Channel, ligand-gated; Membrane protein, integral; Membrane protein, multi-pass; Transporter; Transporter, ion channel P22723 14406 11 A5|11 24.8 cM mouse K373-ub 11956710 KDKDKKKkNPLLRMF Neur_chan_memb protein degradation; receptor internalization, altered 19815531 1 0 0 regulation of the late endosomal/lysosomal trafficking of GABA receptors, regulation of synaptic transmission -Mst1r Ron EC 2.7.10.1; KINASE; Kinase, protein; Membrane protein, integral; Protein kinase, TK; Protein kinase, tyrosine (receptor) Q62190 19882 9 59.07 cM|9 F1 mouse Y1294-p 456484 EYCPDSLyHVMLRCW PK_Tyr_Ser-Thr enzymatic activity, induced Src(NOT_REPORTED) 16103119 2 0 0 this site is responsible for constitutive activation of the MAP kinase pathway -Nr3c1 GR DNA-binding; Mitochondrial; Nuclear receptor; Transcription factor P06536 24413 18p11 rat S224-p 447967 DLEFSAGsPSKDTNE GCR intracellular localization 25330740 20 7 0 -VHL VHL Tumor suppressor; UBIQUITIN LIGASE; Ubiquitin ligase P40337 7428 3p25.3 human S111-p 22516600 GTGRRIHsYRGHLWL VHL molecular association, regulation cell cycle regulation; carcinogenesis, inhibited; apoptosis, induced; transcription, induced Tip60(INDUCES); p300(INDUCES) 22071692 1 0 1 positive regulator of p53; initiates transcription on p53 target gene promoters in response to DNA damage; tumor suppresor; required for p53-dependent cell cycle arrest and apoptosis -Stx1a STX1A Membrane protein, integral; Vesicle P32851 116470 12q12 rat T23-p 27909086 DDDDVTVtVDRDRFM endocytosis, altered; exocytosis, induced 33582301 1 1 0 -NHERF1 NHERF Adaptor/scaffold; Motility/polarity/chemotaxis O14745 9368 17q25.1 human S339-p 455752 ERAHQKRsSKRAPQM EBP50_C molecular association, regulation CFTR(INDUCES); Ezrin(DISRUPTS) 17613530; 35140182 5 1 18 -SATB1 SATB1 DNA-binding; Transcription factor Q01826 6304 3p24.3 human K744-sm 2293715 TNTLFSVkLEEELSV protein degradation; intracellular localization apoptosis, induced 18408014 2 1 0 -Traf2 TRAF2 Autophagy; EC 6.3.2.-; Ligase; UBIQUITIN LIGASE; Ubiquitin conjugating system; Ubiquitin ligase P39429 22030 2|2 A3 mouse K31-ub 486266 LGTRLEAkYLCSACK protein degradation; molecular association, regulation; phosphorylation transcription, induced TAB2(INDUCES) 11909853; 19150425 2 1 0 induces IKB phosphorylation -SOD2 SOD2 EC 1.15.1.1; Mitochondrial; Oxidoreductase P04179 6648 6q25.3 human R197-m2 1872904404 YLQYKNVrPDYLKAI Sod_Fe_C cell cycle regulation 22710435 1 1 0 quiescent fibroblasts are dimethylated at K122, and R197 and are also dimethylated in proliferating cells -Nlrp3 NLRP3 Inhibitor Q8R4B8 216799 11|11 B1.3 mouse Y132-p 1869022700 ICKKKKDyCKMYRRH activity, inhibited 32352641 1 0 0 inhibits inflammasome assembly -CIC capicua DNA-binding; Transcription factor Q96RK0 23152 19q13.2 human S1389-p 4952030 SPRAILGsYRKKRKN molecular association, regulation; intracellular localization KPNA3(DISRUPTS) 21087211 1 6 0 -PDCD1 PD-1 Apoptosis; Membrane protein, integral Q15116 5133 2q37.3 human Y248-p 50293001 CVPEQTEyATIVFPS molecular association, regulation SHP-2(INDUCES); SHP-1(INDUCES) 15240681 4 0 0 -PTK2 FAK EC 2.7.10.2; KINASE; Kinase, protein; Protein kinase, TK; Protein kinase, tyrosine (non-receptor) Q00944 396416 chicken Y576-p 447889 RYMEDSTyYKASKGK PK_Tyr_Ser-Thr activity, induced; phosphorylation; enzymatic activity, induced 12370821; 9790958 95 65 2523 -ARHGEF1 ARHGEF1 GEF; GEF, Rac/Rho; Motility/polarity/chemotaxis Q92888 9138 19q13.2 human S240-p 4936516 TKSGDKKsGRNFFRK activity, induced transcription, induced; signaling pathway regulation 32881857 1 0 6 regulates RhoA activation and signaling -HDC HDC Amino Acid Metabolism - histidine; EC 4.1.1.22; Lyase P19113 3067 15q21.2 human S195-p 1884002000 YASDQAHsSVEKAGL enzymatic activity, induced 37651872 1 0 0 -EDC3 EDC3 RNA processing Q96F86 80153 15q24.1 human S161-p 1211074 SFRRRHNsWSSSSRH Edc3_linker molecular association, regulation 14-3-3 beta(INDUCES) 20051463 1 36 341 -Crebbp CBP ACETYLTRANSFERASE; Acetyltransferase; DNA-binding; EC 2.3.1.48; Motility/polarity/chemotaxis; Nuclear receptor co-regulator; Transcription, coactivator/corepressor P45481 12914 16 A1|16 2.4 cM mouse S436-p 447689 CLPLKNAsDKRNQQT molecular association, regulation cell differentiation, altered; transcription, induced; transcription, altered; cell growth, altered CREB(DISRUPTS) 11463380; 16908541; 20152182 5 0 0 -Slc12a1 NKCC2 Membrane protein, integral; Membrane protein, multi-pass; Transporter; Transporter, SLC family P55016 25065 3q36 rat T114-p 459122 KIEYYRNtGSVSGPK AA_permease_N activity, induced; molecular association, regulation ANXA2(DISRUPTS) 18550832; 24526686 4 2 0 Low chloride hypotonic stress enhances raft association of NKCC2 and AnxA2; observed in triple mutant T96/111/101A -Lpin1 LPIN1 EC 3.1.3.4; Phosphatase, lipid Q91ZP3 14245 12 A1.1|12 7.9 cM mouse K599-sm 10902806 RGRNATIkEESKPEQ intracellular localization transcription, induced 19753306 1 0 0 -YBX1 YB-1 RNA processing; RNA splicing; RNA-binding; Transcription factor P67809 4904 1p34.2 human K304-ub 3934716 PQDGKETkAADPPAE RNA stability, inhibited 35273154 1 5 64 SIAH1-mediated YBX-1 ubiquitination, which leads to accelerated mRNA degradation which could be important for chemosensitization in epithelial ovarian cancer (EOC) -FOXM1 FOXM1 iso2 DNA-binding; Transcription factor Q08050-2 2305 12p13.33 human S251-p 10897608 MIQFAINsTERKRMT Forkhead molecular association, regulation; phosphorylation cell cycle regulation; transcription, induced CBP(INDUCES) 19737929 1 1 0 increases phosphorylation of FOXM1 T596 by CDK1 in vivo and in vitro -Irs1 IRS1 Adaptor/scaffold; Motility/polarity/chemotaxis P35569 16367 1 C5|1 42.0 cM mouse S318-p 451399 MVGGKPGsFRVRASS phosphorylation 16418171 12 17 3 Phosphorylation of S318 leads to an increase of phospho-Ser473 Akt1 in L6GLUT4 myotubes. -Cdc25a CDC25A EC 3.1.3.48; Motility/polarity/chemotaxis; PHOSPHATASE; Protein phosphatase, dual-specificity P48964 12530 9 F2|9 59.81 cM mouse S123-p 449127 PALKRSHsDSLDHDT M-inducer_phosp protein degradation; intracellular localization cell cycle regulation; apoptosis, altered; cytoskeletal reorganization 15928203; 18936171 7 1 0 centrosome amplification and colocalization with Cdc25A in S122A mutant cells -Drd1 DRD1 GPCR, family 1; Membrane protein, integral; Membrane protein, multi-pass; Receptor, GPCR P18901 24316 17p14 rat T428-p 458339 SVILDYDtDVSLEKI receptor desensitization, altered; intracellular localization 16338988 2 0 0 -FPR2 FPR2 GPCR, family 1; Membrane protein, integral; Membrane protein, multi-pass; Motility/polarity/chemotaxis; Receptor, GPCR P25090 2358 19q13.41 human Y302-p 3176600 SCLNPMLyVFVGQDF 7tm_1; TM receptor desensitization, altered 11063592 1 0 0 downregulates PLD activation -BLM BLM DNA repair, damage; DNA replication; EC 3.6.4.12; Helicase P54132 641 15q26.1 human K105-ub 28132100 ETQRGGSkSLLPDFL BLM_N molecular association, regulation; intracellular localization DNA repair, inhibited RAP80(INDUCES) 23708797 1 2 0 -MAPT Tau iso8 ACETYLTRANSFERASE; Acetyltransferase; Cytoskeletal P10636-8 4137 17q21.31 human S324-p 449328 KVTSKCGsLGNIHHK Tubulin-binding molecular association, regulation cytoskeletal reorganization 10090741; 21204788; 28760828 12 8 2 impaired capacity to drive microtubule assembly -AURKB AurB EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, Other; Protein kinase, Ser/Thr (non-receptor) Q96GD4 9212 17p13.1 human S227-p 4271812 GWSVHAPsLRRKTMC Pkinase molecular association, regulation; intracellular localization; phosphorylation cell cycle regulation 14-3-3 zeta(DISRUPTS) 28004745; 34143863 2 7 4 C1A and C1B domains are necessary for localization, and inter-C1 domain (IC1D) domains for retention at the midbody, S350 dephosphorylation is necessary for 14-3-3 complex assembly, and for Aurora B S227 phosphorylation at the midbody; substrate specificity; abscission, cytokinesis -UGT1A3 UGT1A3 Carbohydrate Metabolism - ascorbate and aldarate; Carbohydrate Metabolism - pentose and glucuronate interconversions; Carbohydrate Metabolism - starch and sucrose; Cofactor and Vitamin Metabolism - porphyrin and chlorophyll; Cofactor and Vitamin Metabolism - retinol; EC 2.4.1.17; Lipid Metabolism - androgen and estrogen; Membrane protein, integral; Transferase; Xenobiotic Metabolism - drug metabolism - cytochrome P450; Xenobiotic Metabolism - drug metabolism - other enzymes; Xenobiotic Metabolism - metabolism by cytochrome P450 P35503 54659 2q37.1 human S43-p 34357665 IDGSHWLsMREVLRE UDPGT enzymatic activity, induced 26094731 1 0 1 -CTTN Cortactin Actin-binding; Cytoskeletal; Motility/polarity/chemotaxis Q14247 2017 11q13.3 human S405-p 447700 KTQTPPVsPAPQPTE protein degradation; molecular association, regulation; ubiquitination; protein conformation carcinogenesis, altered; endocytosis, altered; cell motility, induced; cell motility, altered; cell motility, inhibited; cytoskeletal reorganization; cell adhesion, altered N-WASP(INDUCES); WAVE2(INDUCES) 20444238; 21079800; 21856159; 24188565; 24265417; 24867096; 26490115 18 87 128 -Gria2 GluR2 Channel, calcium; Channel, ligand-gated; Membrane protein, integral; Membrane protein, multi-pass P19491 29627 2q33 rat Y873-p 35547400 FATYKEGyNVYGIES receptor internalization, induced 14976558 2 0 0 long-term depression of AMPA receptor-mediated excitatory postsynaptic currents -Crtc2 TORC2 Transcription, coactivator/corepressor Q3U182 74343 3|3 F1 mouse S369-p 454651 PQLQGSHsHPSLPAS molecular association, regulation 14-3-3 beta(INDUCES) 18626018 2 1 6 -Trp53bp1 53BP1 DNA repair, damage; Transcription, coactivator/corepressor P70399 27223 2|2 E5 mouse S382-p 452380 TPFIVPSsPTEQGGR molecular association, regulation cell cycle regulation PLK1(INDUCES) 20126263 3 59 6 -GGA1 GGA1 Adaptor/scaffold; Vesicle Q9UJY5 26088 22q13.1 human S355-p 455525 EQPSASVsLLDDELM molecular association, regulation; activity, inhibited IGF2R(DISRUPTS) 12060753 4 0 0 -NUDC NUDC Cell cycle regulation; Cytoskeletal Q9Y266 10726 1p36.11 human K39-ac 31068003 FFSFLRRkTDFFIGG Nudc_N cell cycle regulation 24069238 1 1 0 -H2AZ1 H2AZ DNA-binding P0C0S5 3015 4q23 human K13-ac 466365 GKDSGKAkTKAVSRS Histone molecular association, regulation transcription, induced FALZ(INDUCES) 32356653 2 6 292 K7ac preferentially engaging the binding site, acetylation at K7ac and K13ac is also the highest-affinity acetylation pattern of isoform I -EZH2 EZH2 iso2 EC 2.1.1.43; METHYLTRANSFERASE; Methyltransferase; Methyltransferase, protein lysine Q15910-2 2146 7q36.1 human S734-p 29606713 LFFDYRYsQADALKY protein degradation; molecular association, regulation cell cycle regulation; DNA repair, induced SUZ12(DISRUPTS); EED(DISRUPTS) 24162653 1 0 0 -ARHGAP25 ARHGAP25 GAP; GAP, Rac/Rho P42331 9938 2p13.3 human S487-p 3951314 EGHRRTMsQDLRQLS activity, inhibited 36190314 1 12 5 -PKM PKM iso2 Carbohydrate Metabolism - glycolysis and gluconeogenesis; Carbohydrate Metabolism - pyruvate; EC 2.7.1.40; KINASE; Kinase, other; Mitochondrial; Nucleotide Metabolism - purine P14618-2 5315 15q23 human T365-p 31886917 CIMLSGEtAKGDYPL PK enzymatic activity, induced apoptosis, induced 26258887 1 1 1 -LILRB2 LILRB2 Membrane protein, integral; Receptor, misc. Q8N423 10288 19q13.42 human Y532-p 451318 DAQEENLyAAVKDTQ molecular association, regulation; phosphorylation CSK(INDUCES); SHP-1(INDUCES) 11907092; 15474475 2 3 11 Mutation of Y533 prevented binding in vivo. ; necessary for serotonin release; tyrosine phosphorylation of ILT2 -TSC2 TSC2 Cell cycle regulation; GAP; GAP, misc.; Nuclear receptor co-regulator; Tumor suppressor P49815 7249 16p13.3 human S1387-p 450212 QPLSKSSsSPELQTL phosphorylation carcinogenesis, inhibited; autophagy, induced; cell growth, inhibited; cell growth, induced; transcription, inhibited; signaling pathway regulation 20363874; 33271062; 34247189; 35670018 19 14 6 -TP73 p73 DNA-binding; Transcription factor; Tumor suppressor O15350 7161 1p36.32 human S426-p 33602702 GGMNKLPsVNQLVGQ intracellular localization 24874608 1 0 0 nuclear localization -VIM Vimentin Cytoskeletal; Motility/polarity/chemotaxis P08670 7431 10p13 human S9-p 455450 STRSVSSsSYRRMFG Filament_head cell motility, altered 19291697 4 4 3 -Naca NACA Motility/polarity/chemotaxis; Transcription, coactivator/corepressor P70670 17938 10|10 D3 mouse S2015-p 454238 PELEEQDsTQTATQQ intracellular localization transcription, altered 19884350 2 1 0 regulates expression of osteocalcin and COL1A1 -TPH2 TPH2 Amino Acid Metabolism - tryptophan; EC 1.14.16.4; Oxidoreductase Q8IWU9 121278 12q21.1 human S19-p 470085 YWARRGFsLDSAVPE protein stabilization; molecular association, regulation; enzymatic activity, induced 14-3-3 beta(INDUCES); 14-3-3 epsilon(INDUCES); 14-3-3 gamma(INDUCES) 15663479; 17973628; 18339632 5 5 2 modulates serotonin production -MST1R Ron EC 2.7.10.1; KINASE; Kinase, protein; Membrane protein, integral; Protein kinase, TK; Protein kinase, tyrosine (receptor) Q04912 4486 3p21.31 human Y1360-p 456488 YVQLPATyMNLGPST molecular association, regulation; phosphorylation cell growth, altered Met(INDUCES) 10871856; 11064459 5 0 0 -VCPIP1 VCIP135 Cell cycle regulation; DEUBIQUITINASE; EC 3.4.19.12; Protease; Ubiquitin conjugating system; Ubiquitin-specific protease Q96JH7 80124 8q13.1 human T761-p 472123 GPSSAPAtPTKAPYS molecular association, regulation cell cycle regulation VCP(DISRUPTS) 23500464 1 16 25 Golgi disassembly at mitosis, inhibits membrane fusion -KIT Kit EC 2.7.10.1; KINASE; Kinase, protein; Membrane protein, integral; Oncoprotein; Protein kinase, TK; Protein kinase, tyrosine (receptor) P10721 3815 4q12 human Y547-p 13876400 VMILTYKyLQKPMYE enzymatic activity, induced 20147452 1 1 0 -TLR7 TLR7 Membrane protein, integral Q9NYK1 51284 Xp22.2 human Y1024-p 1875831802 TNPQAHPyFWQCLKN TIR ubiquitination; intracellular localization; phosphorylation transcription, inhibited; signaling pathway regulation 34936223 1 0 0 inhibits ubiquitination of itself, regulates NF-kB phosphorylation and TLR7/NF-kB signaling -EYA1 EYA1 Apoptosis; Cell development/differentiation; DNA repair, damage; EC 3.1.3.16; EC 3.1.3.48; Motility/polarity/chemotaxis; PHOSPHATASE; Protein phosphatase, tyrosine (non-receptor) Q99502 2138 8q13.3 human K43-sm 41156502 TPNGTEVkTEPMSSS transcription, inhibited 24954506 1 0 0 -Kcnj5 GIRK4 Channel, potassium; Membrane protein, integral; Membrane protein, multi-pass P48548 29713 8q21 rat Y32-p 3146604 IPKQARDyIPIATDR activity, inhibited 10833508 1 0 0 -Cebpb C/EBP-beta DNA-binding; Motility/polarity/chemotaxis; Transcription factor P28033 12608 2 H3|2 87.58 cM mouse K117-ac 473551 SLGRAGAkAAPPACF transcription, induced 17110376 1 0 0 increased activation of C/EBP-beta promoter -Drd1 DRD1 GPCR, family 1; Membrane protein, integral; Membrane protein, multi-pass; Receptor, GPCR P18901 24316 17p14 rat S259-p 455303 ECAQSESsFKMSFKR 7tm_1 receptor desensitization, altered 14660631 2 0 0 -MYLK smMLCK EC 2.7.11.18; KINASE; Kinase, protein; Protein kinase, CAMK; Protein kinase, Ser/Thr (non-receptor) Q15746 4638 3q21.1 human S947-p 4739853 EEERKVHsPQQVDFR molecular association, regulation; intracellular localization ACTN1(INDUCES) 34302892 1 12 1 -CACNA1D CACNA1D Channel, calcium; Membrane protein, integral; Membrane protein, multi-pass Q01668 776 3p21.1 human S1490-p 465731 DEFKRIWsEYDPEAK GPHH activity, induced 16763033 1 2 0 required for IGF-1 induced channel potentiation -Nos1 nNOS Amino Acid Metabolism - arginine and proline; EC 1.14.13.39; Oxidoreductase P29476 24598 12q16 rat K1300-ac 2459101 REETLQAkNKGVFRE NAD_binding_1 activity, induced 18415985 1 0 0 -KHDRBS1 KHDRBS1 RNA-binding Q07666 10657 1p35.2 human T317-p 18504947 RGALVRGtPVRGAIT molecular association, regulation; intracellular localization cell cycle regulation; RNA splicing, inhibited; cell growth, induced; apoptosis, inhibited RNA(DISRUPTS) 36537190 1 4 1 -PROX1 PROX1 DNA-binding; Nuclear receptor co-regulator; Transcription factor Q92786 5629 1q32.3 human S79-p 487308 KLLKRANsYEDAMMP protein degradation; molecular association, regulation; ubiquitination carcinogenesis, inhibited; cell growth, inhibited; transcription, induced; signaling pathway regulation DDB1(INDUCES) 36433955 1 10 6 regulates mTOR signaling -WIPF1 WIPF1 Actin-binding; Motility/polarity/chemotaxis O43516 7456 2q31.1 human S488-p 449880 RNESRSGsNRRERGA molecular association, regulation; protein conformation cytoskeletal reorganization WASP(DISRUPTS) 12504004; 24962707 5 0 0 reduces the stability and enhances the mobility of WIP and WASp clusters -TAB1 TAB1 Activator; Motility/polarity/chemotaxis Q15750 10454 22q13.1 human S456-p 22869802 HTQSSSSsSDGGLFR intracellular localization; phosphorylation; enzymatic activity, induced transcription, inhibited 22216226 1 0 0 TAB1 induce p38 MAPK phosphorylation and mRNA destabilization, induces p38 MAPK activation. TAB1 and p38MAPK mutually control eachother's phosphorylation status, activity and intracellular localization. -PTGER4 PTGER4 GPCR, family 1; Membrane protein, integral; Membrane protein, multi-pass; Receptor, GPCR P35408 5734 5p13.1 human S379-p 450697 AMSGHSRsFISRELK molecular association, regulation ARRB1(INDUCES) 14709160 1 0 0 -Tgfb1i1 Hic-5 Motility/polarity/chemotaxis; Nuclear receptor co-regulator; Transcription, coactivator/corepressor Q62219 21804 7|7 F3 mouse Y38-p 456816 TLTPPPPyGHQPQTG cytoskeletal reorganization 16183059 1 1 2 phosphorylation of this site after EGF induction leads to reduction of Rac activity and formation of lamellipodia -CFL1 Cofilin-1 Cytoskeletal; Motility/polarity/chemotaxis; Nuclear receptor co-regulator P23528 1072 11q13.1 human S23-p 9218412 NDMKVRKsSTPEEVK Cofilin_ADF molecular association, regulation cytoskeletal reorganization 14-3-3 zeta(INDUCES) 22855535 1 4 1 inhibition of depolymerization of actin, cessation of degranulation -DDX5 DDX5 EC 3.6.4.13; Helicase; Nuclear receptor co-regulator; Nucleolus; RNA splicing; RNA-binding; Spliceosome P17844 1655 17q23.3 human Y595-p 478485 MNQQAYAyPATAAAP apoptosis, inhibited 17384675 1 1 0 -BLM BLM DNA repair, damage; DNA replication; EC 3.6.4.12; Helicase P54132 641 15q26.1 human S646-p 15349300 LKHERFQsLSFPHTK BDHCT_assoc molecular association, regulation; intracellular localization PML(INDUCES); NCL(INDUCES) 20719863 1 1 0 -Gorasp2 GRASP55 Motility/polarity/chemotaxis; Vesicle Q9R064 113961 3q22 rat T222-p 470124 LPGQMTGtPITPLKD molecular association, regulation cytoskeletal reorganization GRASP55(DISRUPTS) 20083603 2 33 4 inhibits Golgi stack formation in interphase cells and enhances Golgi fragmentation in mitotic cells -Lats1 LATS1 EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, AGC; Protein kinase, Ser/Thr (non-receptor); Tumor suppressor Q8BYR2 16798 10|10 A1 mouse Y200-p 1876860400 SLGENVVyRSESPNS phosphorylation; enzymatic activity, induced cell growth, inhibited; transcription, induced; signaling pathway regulation 35394840 1 1 0 -METTL1 METTL1 EC 2.1.1.33; METHYLTRANSFERASE; Methyltransferase; RNA processing Q9UBP6 4234 12q14.1 human S27-p 3627513 YYRQRAHsNPMADHT enzymatic activity, inhibited; protein conformation 15861136; 25233213; 36599985 3 23 66 -FCGR2B FCGR2B Cell surface; Membrane protein, integral; Oncoprotein P31994 2213 1q23.3 human Y292-p 448507 GAENTITySLLMHPD molecular association, regulation SHP-2(INDUCES) 10704309 4 2 1 -MYC Myc DNA-binding; Nucleolus; Oncoprotein; Transcription factor P01106 4609 8q24.21 human K407-sm 40724411 ENNEKAPkVVILKKA HLH protein degradation; ubiquitination transcription, inhibited 25895136 1 2 0 -Ppargc1b PGC-1 beta Nuclear receptor co-regulator; Transcription, coactivator/corepressor Q8VHJ7 170826 18|18 E1 mouse K202-ac 7761203 VDGTQDKkTPTLRAQ intracellular localization transcription, inhibited 19491097 1 1 0 -PTGER4 PTGER4 GPCR, family 1; Membrane protein, integral; Membrane protein, multi-pass; Receptor, GPCR P35408 5734 5p13.1 human S374-p 450695 QRTSSAMsGHSRSFI molecular association, regulation ARRB1(INDUCES) 14709160 1 0 1 -UBA52-RPS27A-UBB-UBC ubiquitin Ubiquitin-like modifier P62988 2p16 human K48-ac 459086 QRLIFAGkQLEDGRT ubiquitin protein degradation; molecular association, regulation; ubiquitination UBE2V1(INDUCES) 2160452; 25527407 6 6 0 inhibits polyubiquitin chain elongation; substrate degradation in ubiquitin mediated proteolysis -Slc1a2 GLT1 Membrane protein, integral; Membrane protein, multi-pass; Transporter; Transporter, SLC family P31596 29482 3q32 rat S563-p 486052 NGKSADCsVEEEPWK intracellular localization; activity, inhibited 34516830 1 6 0 -Klf1 KLF1 C2H2-type zinc finger protein; DNA-binding; Transcription factor P46099 16596 8 41.3 cM|8 C3 mouse K270-ac 460630 SRRTLAPkRQAAHTC cell differentiation, induced; transcription, induced 12920040 3 0 0 -Crtc3 TORC3 Transcription, coactivator/corepressor Q91X84 70461 7|7 D3 mouse S370-p 1210886 SLRLFSLsNPSLSTT molecular association, regulation; activity, inhibited transcription, inhibited 14-3-3 beta(INDUCES) 23033494; 25114223 2 41 47 inhibits nuclear localization; Dasatinib and bosutinib induce IL-10 production and induced transcription -Pip5k1b PIP5K1B Carbohydrate Metabolism - inositol phosphate; EC 2.7.1.68; Kinase, lipid P70181 18719 19|19 B mouse S413-p 27461455 PSKKRCNsIAALKAT enzymatic activity, inhibited 23909401 1 5 0 -TAB3 TAB3 Adaptor/scaffold Q8N5C8 257397 Xp21.2 human S408-gl 54400803 TATTPPSsSPSRGIS cell motility, induced 27009840 1 2 0 induced cell migration and invasion -GIT1 GIT1 GAP; GAP, ARF; Motility/polarity/chemotaxis Q9Y2X7 28964 17q11.2 human Y321-p 15702200 FLPVNPEySATRNQG molecular association, regulation; intracellular localization cell motility, induced; cell adhesion, altered FAK(INDUCES) 22302306 4 0 0 GIT1 Y321 is necessary for FAK activation localization at focal adhesions -Slc12a5 KCC2 Membrane protein, integral; Membrane protein, multi-pass; Transporter; Transporter, SLC family Q91V14 57138 2|2 H3 mouse Y926-p 14932400 SDISAYTyEKTLVME SLC12 protein degradation 20600929 1 0 0 decreases the cell surface stability of SLC12A5 (aka KCC2) -TARDBP TDP-43 RNA-binding Q13148 23435 1p36.22 human Y155-p 464438 GFVRFTEyETQVKVM RRM_1 molecular association, regulation; intracellular localization RNA(DISRUPTS) 28167528 1 1 15 nuclear recruitment, decrease RNA binding affinity (fluorescence-based RNA binding assay, regulation of splicing -RELA NFkB-p65 DNA-binding; Nuclear receptor co-regulator; Transcription factor Q04206 5970 11q13.1 human S536-p 447800 SGDEDFSsIADMDFS protein degradation; acetylation; molecular association, regulation; protein stabilization; phosphorylation; activity, induced; ubiquitination; intracellular localization cell cycle regulation; carcinogenesis, induced; apoptosis, altered; apoptosis, induced; cell motility, induced; RNA stability, induced; RNA stability, inhibited; signaling pathway regulation; cell growth, induced; cell motility, altered; transcription, inhibited; cell growth, altered; carcinogenesis, altered; transcription, induced; transcription, altered; endocytosis, induced; cell differentiation, induced; apoptosis, inhibited TAFII31(INDUCES); CDK5RAP3(DISRUPTS); PPP2CA(DISRUPTS) DNA(INDUCES); DNA(DISRUPTS) 10521409; 11259436; 12419817; 12767944; 12842894; 14963024; 15100319; 15128824; 15192014; 15489227; 15849198; 16105840; 16148147; 16163708; 16407239; 16840782; 17409387; 17595324; 17785205; 18453612; 19073147; 20224721; 20507904; 20696864; 20961594; 21177808; 21816815; 24442433; 25136068; 26082493; 26170389; 26307684; 26693062; 26729520; 26826124; 27244888; 27528614; 27555662; 28122346; 28416608; 31980577; 32123095; 33459422; 33578126; 33579825; 33762327; 33789981; 33883226; 33914760; 33941613; 33971703; 34017102; 34082140; 34219129; 34380537; 34588619; 34785213; 35197571; 35588785; 36048884; 36116131; 36264688; 36460775; 36931391; 37450351 254 4 0 -MYF5 Myf-5 DNA-binding; Transcription factor P13349 4617 12q21.31 human S133-p 457385 NAIRYIEsLQELLRE HLH activity, induced 9461343 1 0 0 -Nefl NFL Cytoskeletal P08551 18039 14|14 D1 mouse S50-p 457403 YSAPVSSsLSVRRSY Filament_head molecular association, regulation; intracellular localization 14-3-3 gamma(INDUCES) 23230147 2 0 0 regulates NF-L dynamic exchange rate and neurofilament disassembly -Lrp6 LRP6 Membrane protein, integral; Receptor, misc. O88572 16974 6 G1|6 65.37 cM mouse S1607-p 21241903 HLYPPPPsPCTDSS_ signaling pathway regulation 24692544 2 1 0 Wnt signaling -YAP1 YAP1 Oncoprotein; Transcription, coactivator/corepressor P46937 10413 11q22.1 human T119-p 4959542 AGTAGALtPQHVRAH cell cycle regulation; carcinogenesis, induced; cell motility, induced; cytoskeletal reorganization 24101154 4 25 111 -APP APP Apoptosis; Cell surface; Membrane protein, integral; Receptor, misc.; Transcription factor P05067 351 21q21.3 human T743-p 448523 VEVDAAVtPEERHLS APP_amyloid protein stabilization; molecular association, regulation; intracellular localization cell cycle regulation; transcription, induced; cell growth, altered Abl(INDUCES); Src(INDUCES); DAB1(INDUCES); PLCG2(INDUCES); APPBP1(INDUCES); SHC3(INDUCES); SHC1(INDUCES); GRB2(INDUCES); GRB7(INDUCES); PLCG1(INDUCES); Fe65(INDUCES); PIN1(INDUCES); SHC2(INDUCES); LYN(INDUCES); NCK1(INDUCES); CRK(INDUCES) 14722157; 17634293; 19602287; 21151996; 28720718 39 5 3 dopaminergic (DA) neurodegeneration -Runx1 AML1 DNA-binding; Oncoprotein; Transcription factor Q03347 12394 16 C4|16 53.7 cM mouse Y379-p 51211401 SPSYHLYyGASAGSY RunxI activity, induced; protein stabilization transcription, induced HDAC1(DISRUPTS) DNA(INDUCES) 26598521 1 0 0 -RAF1 RAF1 EC 2.7.11.1; KINASE; Kinase, protein; Oncoprotein; Protein kinase, Ser/Thr (non-receptor); Protein kinase, TKL P04049 5894 3p25.2 human Y341-p 447750 GQRDSSYyWEIEASE enzymatic activity, inhibited; intracellular localization; protein conformation; phosphorylation; enzymatic activity, induced carcinogenesis, induced; cell growth, induced; cell motility, induced 10998357; 11259591; 11274179; 11447113; 12446733; 12551923; 12865432; 17998336; 18775988; 19595761; 27014871; 28694330; 7692235 35 1 1 dimerization, ERK activation -Apobec3 APOBEC3B iso3 EC 3.5.4.-; Hydrolase; RNA-binding Q99J72-3 80287 15 48.6 cM|15 E1 mouse T42-p 31825500 YAKGRKDtFLCYEVT APOBEC2 enzymatic activity, induced 24453360 1 0 0 -RIN1 Rin1 GEF; GEF, Rab Q13671 9610 11q13.2 human S351-p 451364 RPLLRSMsAAFCSLL molecular association, regulation; intracellular localization 14-3-3 beta(INDUCES) 11784866 3 23 4 -HIF1A HIF1A Autophagy; DNA-binding; Transcription factor Q16665 3091 14q23.2 human S589-p 34494909 PLESSSAsPESASPQ protein degradation cell growth, inhibited; cell motility, inhibited; signaling pathway regulation 30254159 1 0 0 PI3K pathway and AKT are strongly activated by IRIS -Cxcr4 CXCR4 GPCR, family 1; Membrane protein, integral; Membrane protein, multi-pass; Receptor, GPCR P70658 12767 1 E3|1 56.43 cM mouse S354-p 12575201 VSTESESsSFHSS__ receptor internalization, induced; receptor desensitization, inhibited; phosphorylation 23734232 1 2 1 -Sirt2 SIRT2 DEACETYLASE; Deacetylase; EC 3.5.1.- Q8VDQ8 64383 7|7 B1 mouse S368-p 482809 PNPSTTIsPGKSPPP intracellular localization transcription, altered 35443760 7 31 0 -Prkaca PKACA EC 2.7.11.11; KINASE; Kinase, protein; Protein kinase, AGC; Protein kinase, Ser/Thr (non-receptor) P05132 18747 8|8 C2 mouse S339-p 449886 EEEEIRVsINEKCGK molecular association, regulation PDK1(INDUCES) 19530248 13 36 28 -Gch1 GCH1 Cofactor and Vitamin Metabolism - folate biosynthesis; EC 3.5.4.16; Hydrolase P22288 29244 15p14 rat T91-p 10428813 KTPWRAAtAMQFFTK GTP_cyclohydroI enzymatic activity, induced 19762783 1 0 0 -Per1 PER1 Transcription factor O35973 18626 11|11 B3 mouse S663-p 451684 SYTASSAsDDDKQRA intracellular localization 15148313 1 0 0 -MDM2 MDM2 EC 6.3.2.-; EC 6.3.2.19; Inhibitor; Ligase; NEDDYLATION LIGASE; Neddylation Ligase; Nucleolus; Oncoprotein; UBIQUITIN LIGASE; Ubiquitin conjugating system; Ubiquitin ligase Q00987 4193 12q15 human S256-p 459215 FEVESLDsEDYSLSE activity, induced 12167711 3 1 0 promotes p53 degradation -Ncl NCL DNA-binding; Helicase; Nuclear receptor co-regulator; Nucleolus; RNA-binding P09405 17975 1 C5|1 43.94 cM mouse S41-p 468244 SEDEDDSsGEEEVVI molecular association, regulation carcinogenesis, induced; cell growth, induced; transcription, induced RNA(INDUCES) 37039106 1 41 7 -MYC Myc DNA-binding; Nucleolus; Oncoprotein; Transcription factor P01106 4609 8q24.21 human T358-p 25300958 ISNNRKCtSPRSSDT Myc_N carcinogenesis, inhibited; transcription, inhibited 24030976 2 2 1 -CERS4 LASS4 DNA-binding; Membrane protein, integral; Membrane protein, multi-pass Q9HA82 79603 19p13.2 human S347-p 36704607 IRSDVEEsDSSEEAA enzymatic activity, induced 26887952 1 2 0 -CS CS Carbohydrate Metabolism - citrate (TCA) cycle; Carbohydrate Metabolism - glyoxylate and dicarboxylate; EC 2.3.3.1; Mitochondrial; Transferase O75390 1431 12q13.3 human K395-m3 2358300 LLEQGKAkNPWPNVD Citrate_synt enzymatic activity, inhibited 28887308 2 2 3 -S100A11 S100A11 Calcium-binding; Cell cycle regulation; DNA replication P31949 6282 1q21.3 human S94-p 10888706 LAMACHDsFLKAVPS intracellular localization cell growth, altered NCL(INDUCES) 14623863 1 1 1 Nuclear translocation is mediated by T10 phosphorylation. Calcium induced growth inhibition is mediated by T10 and S94 phosphorylation. -MITF MITF iso9 DNA-binding; Oncoprotein; Transcription factor O75030-9 4286 3p13 human S405-p 31858102 PGASKTSsRRSSMSM DUF3371 protein degradation 25605940 1 1 0 -PRKD1 PRKD1 Autophagy; EC 2.7.11.13; KINASE; Kinase, protein; Motility/polarity/chemotaxis; Protein kinase, CAMK; Protein kinase, Ser/Thr (non-receptor) Q15139 5587 14q12 human S205-p 449896 GVRRRRLsNVSLTGV molecular association, regulation 14-3-3 beta(INDUCES) 15755722 8 36 86 -STAT3 STAT3 DNA-binding; Motility/polarity/chemotaxis; Nuclear receptor co-regulator; Transcription factor P40763 6774 17q21.2 human S727-p 448191 NTIDLPMsPRTLDSL activity, induced; molecular association, regulation; intracellular localization; activity, inhibited; phosphorylation cell cycle regulation; apoptosis, altered; carcinogenesis, induced; signaling pathway regulation; cell differentiation, altered; cell growth, induced; cell motility, altered; transcription, inhibited; cell growth, altered; carcinogenesis, inhibited; carcinogenesis, altered; transcription, induced; transcription, altered; DNA repair, induced; autophagy, induced; apoptosis, inhibited; autophagy, inhibited gp130(DISRUPTS); p300(INDUCES) DNA(INDUCES) 10521505; 10660304; 10727406; 10845908; 11322950; 11335711; 11350938; 11429693; 11536047; 11872739; 12087100; 12208955; 12562765; 12637318; 12684046; 14551213; 15155836; 15465816; 16951338; 17145757; 17209045; 17993646; 18550668; 18829527; 19265112; 20228845; 20516069; 20595392; 20871632; 21159613; 21398617; 21878628; 23740979; 24615012; 26028030; 28351946; 32015548; 33662027; 33689932; 33772065; 34207842; 34380633; 34852826; 34885140; 35031324; 35538489; 35595309; 35670018; 35928250; 36017196; 36103247; 36437465; 36443287; 7543024 227 57 67 -CDH1 CDH1 Cell adhesion; Membrane protein, integral; Motility/polarity/chemotaxis; UBIQUITIN LIGASE; Ubiquitin ligase P12830 999 16q22.1 human Y753-p 456024 DDTRDNVyYYDEEGG endocytosis, induced 29311227 2 2 42 -Kcnma1 KCNMA1 iso4 Channel, potassium; Endoplasmic reticulum; Membrane protein, integral; Membrane protein, multi-pass Q08460-4 16531 14|14 A3 mouse S701-p 23013300 GCRRPKMsIYKRMRR intracellular localization; activity, inhibited; palmitoylation 22084244 1 0 0 regulation of STREX cell surface expression, inhibits palmitoylation -RBM38 RBM38 RNA-binding Q9H0Z9 55544 20q13.31 human S195-p 29606707 DQYPYAAsPATAASF molecular association, regulation cell cycle regulation; carcinogenesis, induced; cell growth, inhibited; signaling pathway regulation; translation, induced; RNA stability, altered RBM38(DISRUPTS); eIF4G(INDUCES); AGO2(DISRUPTS); EIF4E(DISRUPTS) 24142875; 25823026; 30567739; 33472892; 33664057; 35568694 7 0 0 -TAB1 TAB1 Activator; Motility/polarity/chemotaxis Q15750 10454 22q13.1 human S395-gl 25160100 YPVSVPYsSAQSTSK activity, induced; phosphorylation signaling pathway regulation 22307082 1 3 0 may regulate TAB1 phosphorylation at S438; autophosphorylation of TAK1 T187 is reduced in 0-GlcNAc S395A mutatnt of TAB1 -Pax3 PAX3 DNA-binding; Oncoprotein; Transcription factor P24610 18505 1 C4|1 39.79 cM mouse S205-p 4145506 APQSDEGsDIDSEPD cell growth, induced; transcription, inhibited 27588498 6 1 0 -KDR VEGFR2 EC 2.7.10.1; KINASE; Kinase, protein; Membrane protein, integral; Protein kinase, TK; Protein kinase, tyrosine (receptor) P35968 3791 4q12 human Y822-p 56654294 EHCERLPyDASKWEF molecular association, regulation cytoskeletal reorganization Src(INDUCES) 35942094 1 1 0 mediates filopodia in endothelial cells -LY9 CD229 Cell surface; Membrane protein, integral Q9HBG7 4063 1q23.3 human Y651-p 455757 EIPESPTyENFT___ molecular association, regulation; receptor internalization, altered GRB2(INDUCES) 15879090 1 0 1 Grb2 binding induces CD229 internalization (dominant negative Grb2 (only SH2 domain) inhibits this as does Y651F mutation). -IRAK4 IRAK4 EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, Ser/Thr (non-receptor); Protein kinase, TKL Q9NWZ3 51135 12q12 human S346-p 2045338 FAQTVMTsRIVGTTA PK_Tyr_Ser-Thr protein conformation; enzymatic activity, induced 17141195; 17161373; 17312103 6 3 1 -Plk4 PLK4 EC 2.7.11.21; KINASE; Kinase, protein; Nucleolus; Protein kinase, Other; Protein kinase, Ser/Thr (non-receptor) Q64702 20873 3|3 B mouse T295-p 12654001 ATLSTTItASSGTSL protein degradation; ubiquitination 20100909 2 1 0 -Prkcd PKCD EC 2.7.11.13; KINASE; Kinase, protein; Nuclear receptor co-regulator; Protein kinase, AGC; Protein kinase, Ser/Thr (non-receptor); Protein kinase, tyrosine (non-receptor); Tumor suppressor P28867 18753 14 B|14 18.82 cM mouse S643-p 448591 LNEKPQLsFSDKNLI Pkinase_C intracellular localization; enzymatic activity, induced 15731106; 9305920 29 51 79 PKC-delta phosphorylation mediates monocytic differentiation of 32D myeloid progenitor cells. -PRKCE PKCE EC 2.7.11.13; KINASE; Kinase, protein; Protein kinase, AGC; Protein kinase, Ser/Thr (non-receptor) Q02156 5581 2p21 human T710-p 450184 TREEPVLtLVDEAIV Pkinase_C enzymatic activity, induced cell growth, induced 21806543 3 24 33 -BABAM1 NBA1 DNA repair, damage Q9NWV8 29086 19p13.11 human S29-p 479974 EPRPRTRsNPEGAED molecular association, regulation DNA repair, induced TNKS(INDUCES); RAP80(INDUCES) 26027929 1 26 247 promotes the association of BRCA1-A complex componentsin response to DNA damage -TRAP1 HSP75 Chaperone; Heat shock protein Q12931 10131 16p13.3 human S511-p 55374803 NRHLAEHsPYYEAMK HSP90 carcinogenesis, induced; cell growth, induced 28099845 1 1 0 -RET Ret EC 2.7.10.1; KINASE; Kinase, protein; Membrane protein, integral; Oncoprotein; Protein kinase, TK; Protein kinase, tyrosine (receptor) P07949 5979 10q11.21 human Y791-p 455479 HPHVIKLyGACSQDG PK_Tyr_Ser-Thr phosphorylation transcription, altered 15753368; 20080836 2 0 0 STAT3 Y705 phosphorylation -STK11IP STK11IP Protein kinase, regulatory subunit Q8N1F8 114790 2q35 human S404-p 4716927 EPRTLNPsPAGWFVQ molecular association, regulation; enzymatic activity, inhibited autophagy, inhibited ATP6V1A(INDUCES); ATP6V1B1(INDUCES) 35365663 1 13 3 inhibits V-ATPase activity -Stxbp4 STXBP4 Vesicle Q9WV89 20913 11|11 D mouse S99-p 455472 RAKLRSEsPWEIAFI molecular association, regulation STX4(DISRUPTS); GLUT4(DISRUPTS) 15753124; 17336927 3 1 2 Insulin induced Glut 4 translocation to the plasma membrane. -ARHGDIA RhoGDI alpha Apoptosis; Cell adhesion; Cell development/differentiation; G protein regulator, misc.; Motility/polarity/chemotaxis P52565 396 17q25.3 human S96-p 486318 DLTGDLEsFKKQSFV Rho_GDI activity, induced; molecular association, regulation signaling pathway regulation; transcription, altered RHOA(DISRUPTS); RAC1(DISRUPTS) 17636025; 23776598 3 0 0 promotes RhoA and Rac1 signaling, promotes amylase secretion from pancreatic acini; thrombin induced activation -ACLY ACLY Carbohydrate Metabolism - citrate (TCA) cycle; EC 2.3.3.8; Lyase; Transferase P53396 47 17q21.2 human S451-p 455372 STSTPAPsRTASFSE signaling pathway regulation 26039450 2 4 16 IGF1/AKT/ACL/cardiolipin/ATP pathway -FOXA2 FOXA2 DNA-binding; Transcription factor Q9Y261 3170 20p11.21 human K275-ac 3649009 GAAGSGKkAAAGAQA protein stabilization transcription, induced 24875183 2 2 1 -NME2 NME2 EC 2.7.13.3; EC 2.7.4.6; KINASE; Kinase, nucleoside diphosphate; Kinase, other; Nuclear receptor co-regulator; Nucleotide Metabolism - purine; Nucleotide Metabolism - pyrimidine; Protein kinase, histidine P22392 4831 17q21.33 human S44-p 23255088 AMKFLRAsEEHLKQH NDK molecular association, regulation CFTR(INDUCES) 26950439 1 7 1 induced by forskolin -TNFAIP1 TNFAIP1 DNA replication; Ubiquitin conjugating system Q13829 7126 17q11.2 human S280-p 3195881 SRSQASPsEDEETFE molecular association, regulation; intracellular localization PCNA(INDUCES) 19851886 2 11 0 nuclear localization -MAP2K4 MKK4 EC 2.7.12.2; KINASE; Kinase, protein; Protein kinase, STE; Protein kinase, dual-specificity (non-receptor) P45985 6416 17p12 human S80-p 447655 IERLRTHsIESSGKL activity, inhibited apoptosis, inhibited 11707464 8 16 87 -Slc6a3 DAT Membrane protein, integral; Membrane protein, multi-pass; Transporter; Transporter, SLC family P23977 24898 1p11 rat S7-p 451136 _MSKSKCsVGPMSSV molecular association, regulation; intracellular localization; protein conformation Other(INDUCES) 23161550; 26424792 6 1 1 Ser7 phosphorylation and increased transport correlates with Cys580 palmitoylation, differentially modulate DA transport Vmax, presence of phosphorylation and palmitoylation on cell surface transporters; increases DAT affinity for cocaine analog binding -XRCC5 Ku80 DNA-binding; EC 3.6.1.-; EC 3.6.4.-; Helicase; Nuclear receptor co-regulator; Nucleolus; RNA-binding P13010 7520 2q35 human K545-ub 12344141 PLIEAKKkDQVTAQE Ku_C molecular association, regulation DNA repair, induced DNA(DISRUPTS) 27895153 1 1 1 -CLCN1 CLCN1 Channel, chloride; Membrane protein, integral; Membrane protein, multi-pass; Transporter; Transporter, ion channel P35523 1180 7q34 human T891-p 14645303 LASFRNTtSTRKSTG activity, induced 20511714 1 0 0 -Vcp VCP Chaperone; DNA repair, damage; EC 3.6.4.6; Endoplasmic reticulum; Hydrolase Q01853 269523 4 A5|4 22.95 cM mouse Y805-p 449060 EDNDDDLyG______ molecular association, regulation; ubiquitination autophagy, inhibited UBXN6(DISRUPTS); PLAA(DISRUPTS); NGLY1(DISRUPTS); TSAd(INDUCES) 15752563; 17496150; 36300783 6 10 251 -Stat6 STAT6 DNA-binding; Transcription factor P52633 20852 10 D3|10 74.59 cM mouse R27-me 4258300 VDFPQRLrHLLADWL STAT_int molecular association, regulation; intracellular localization; phosphorylation DNA(INDUCES) 15153491 1 0 0 -TFCP2 TFCP2 DNA-binding; Transcription factor Q12800 7024 12q13.12-q13.13 human S291-p 7965107 TYVNNSPsPGFNSSH activity, inhibited; phosphorylation transcription, inhibited 19237534; 20682773 2 1 0 -LRP1 LRP1 Cell surface; Membrane protein, integral; Motility/polarity/chemotaxis; Receptor, misc. Q07954 4035 12q13.3 human S4517-p 4769100 LYMGGHGsRHSLAST molecular association, regulation; receptor internalization, altered GULP1(INDUCES); DAB1(INDUCES); SHC1(INDUCES) 15272003 1 0 0 -SPG11 SPG11 Membrane protein, integral; Membrane protein, multi-pass Q96JI7 80208 15q21.1 human S1955-p 482126 IPLRRVHsTSSLDSQ receptor internalization, induced; molecular association, regulation 14-3-3 beta(INDUCES); 14-3-3 theta(INDUCES); 14-3-3 zeta(INDUCES); 14-3-3 epsilon(INDUCES); 14-3-3 gamma(INDUCES); 14-3-3 eta(INDUCES) 36096339 1 20 100 -PCBP1 hnRNP E1 RNA splicing; RNA-binding; Translation Q15365 5093 2p13.3 human T127-p 478359 IKEIREStGAQVQVA KH_1 molecular association, regulation; intracellular localization RNA splicing, induced; transcription, induced; translation, induced; signaling pathway regulation DNA(INDUCES); RNA(DISRUPTS) 17389360 1 0 0 PKA-hnRNPE1 pathway -ZNF655 ZNF655 C2H2-type zinc finger protein Q8N720 79027 7q22.1 human K59-ub 52490407 ENKLLIPkQKISEEV protein degradation 26676607 0 1 0 -Rarg RARG iso2 DNA-binding; Nuclear receptor P18911-2 19411 15 F3|15 57.4 cM mouse S379-p 1869601000 ITDLRGIsTKGAERA Hormone_recep activity, induced cell adhesion, altered; signaling pathway regulation 31740618 1 0 0 -NME2 NME2 EC 2.7.13.3; EC 2.7.4.6; KINASE; Kinase, nucleoside diphosphate; Kinase, other; Nuclear receptor co-regulator; Nucleotide Metabolism - purine; Nucleotide Metabolism - pyrimidine; Protein kinase, histidine P22392 4831 17q21.33 human H118-p 474519 QVGRNIIhGSDSVKS NDK molecular association, regulation; enzymatic activity, induced KCNN4(INDUCES) 17157250; 8132589 3 0 0 H1118F mutant retained it's DNA binding and transcriptional activity in vitro. ; in vivo and in vitro -OXTR OXTR GPCR, family 1; Membrane protein, integral; Membrane protein, multi-pass; Receptor, GPCR P30559 5021 3p25.3 human S261-p 1876282802 RVALARVsSVKLISK 7tm_1 molecular association, regulation; phosphorylation signaling pathway regulation G-alpha(q)(INDUCES) 35104164 1 0 0 induces PKD1 and ERK1 phosphorylation, induces MAPK signaling -Csf1r CSFR EC 2.7.10.1; KINASE; Kinase, protein; Membrane protein, integral; Oncoprotein; Protein kinase, TK; Protein kinase, tyrosine (receptor) P09581 12978 18 E1|18 34.41 cM mouse Y697-p 451527 DSEGDSSyKNIHLEK PK_Tyr_Ser-Thr activity, induced; molecular association, regulation; enzymatic activity, induced cell cycle regulation; cell differentiation, altered; cell motility, altered; cytoskeletal reorganization; cell growth, altered GRB2(INDUCES); SOCS1(INDUCES) 11297560; 11997510; 17420255; 17420256; 18519746; 7545432; 8262059; 9380408 14 6 32 -PDCD6IP Alix Adaptor/scaffold; Apoptosis Q8WUM4 10015 3p22.3 human S718-p 8080236 QSIAREPsAPSIPTP molecular association, regulation cell cycle regulation Alix(DISRUPTS) 26859355 1 3 3 EIAV budding, cytokinetic abscission -KIT Kit EC 2.7.10.1; KINASE; Kinase, protein; Membrane protein, integral; Oncoprotein; Protein kinase, TK; Protein kinase, tyrosine (receptor) P10721 3815 4q12 human Y936-p 448019 SESTNHIySNLANCS protein degradation; molecular association, regulation; receptor internalization, altered GRB2(INDUCES); APS(INDUCES); GRB7(INDUCES); CBL(INDUCES) 12444928; 16780420 4 11 100 -SLK SLK EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, STE; Protein kinase, Ser/Thr (non-receptor) Q9H2G2 9748 10q24.33-q25.1 human S348-p 466944 SDLSIASsEEDKLSQ enzymatic activity, inhibited 16837460 1 30 3 site is critical for v-src dependent modulation of SLK kinase activity -MRE11 MRE11A Cell cycle regulation; DNA repair, damage; DNA-binding; Deoxyribonuclease P49959 4361 11q21 human R577-m2 62978404 RGRGRGRrGGRGQNS DNA repair, altered 15741314 0 1 0 -CSNK2A1 CK2A1 EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, Other; Protein kinase, Ser/Thr (non-receptor) P68400 1457 20p13 human T360-p 449985 SGISSVPtPSPLGPL molecular association, regulation; enzymatic activity, induced CK2A1(INDUCES); PGK1(INDUCES) 19941816; 30392930; 36646788 5 0 0 -BIK BIK Apoptosis; Membrane protein, integral; Mitochondrial Q13323 638 22q13.2 human T33-p 448350 TMEVLGMtDSEEDLD bcl-2I13 molecular association, regulation apoptosis, induced Bcl-2(INDUCES); Bcl-xL(INDUCES) 11084041; 14633680 3 0 0 -NUPR1 NUPR1 Apoptosis; Cell cycle regulation; Cell development/differentiation O60356 26471 16p11.2 human K69-ac 465462 HERKLVTkLQNSERK Phospho_p8 intracellular localization 16294328 1 1 0 regulates nuclear transport -CD6 CD6 Cell surface; Membrane protein, integral P30203 923 11q12.2 human S565-p 28095005 PRSNSESsTSSGEDY phosphorylation signaling pathway regulation 23711376 1 0 0 ERK1/2 phosphorylation, MAPK pathway activation -DIABLO DIABLO Apoptosis; Mitochondrial Q9NR28 56616 12q24.31 human S6-p 31857552 __MAALKsWLSRSVT intracellular localization apoptosis, induced 25310587 1 1 0 mitochondrial release of DIABLO during TNF induced apoptosis -Cacng2 Stargazin Channel, calcium; Membrane protein, integral; Membrane protein, multi-pass Q71RJ2 84347 7q34 rat S240-p 455316 YQRRSRSsSRSTEPS molecular association, regulation neural plasticity PSD-95(INDUCES) 25843401 7 0 0 -Tsc2 TSC2 iso2 Cell cycle regulation; GAP; GAP, misc.; Nuclear receptor co-regulator; Tumor suppressor P49816-2 24855 10q12 rat S1342-p 450216 FQPSQPLsKSSSSPE phosphorylation apoptosis, altered; cell growth, altered 14651849 2 1 1 -Cnr1 CNR1 GPCR, family 1; Membrane protein, integral; Membrane protein, multi-pass; Receptor, GPCR P47746 12801 4 A5|4 16.28 cM mouse T468-p 22342301 TMSVSTDtSAEAL__ receptor desensitization, induced 22014214 2 0 0 -ECD SGT1 Transcription, coactivator/corepressor O95905 11319 10q22.2 human S505-p 3178824 PRPNESDsDDLDDED SGT1 molecular association, regulation cell cycle regulation PIH1D1(INDUCES) 24656813; 26711270 2 8 0 -Gli2 GLI2 C2H2-type zinc finger protein; Oncoprotein; Transcription factor Q0VGT2 14633 1 E2.3|1 52.17 cM mouse S817-p 1717520 YFSSRRSsEASPLGG sumoylation 22549777 1 0 2 -MAF MAF Cell development/differentiation; DNA-binding; Oncoprotein; Transcription factor; Tumor suppressor O75444 4094 16q23.2 human Y21-p 25673104 TSPLAMEyVNDFDLM activity, induced; molecular association, regulation transcription, induced DNA(INDUCES) 22798672 2 0 0 Interacts with IL-4 promoter and transactivates IL-4 -Fyn Fyn EC 2.7.10.2; KINASE; Kinase, protein; Oncoprotein; Protein kinase, TK; Protein kinase, tyrosine (non-receptor) Q62844 25150 20q12 rat Y531-p 447883 FTATEPQyQPGENL_ enzymatic activity, inhibited 19625508 19 15 1040 -CDKN1B p27Kip1 Cell cycle regulation; Inhibitor; Oncoprotein; Protein kinase, regulatory subunit P46527 1027 12p13.1 human S12-p 9316305 RVSNGSPsLERMDAR intracellular localization carcinogenesis, induced; apoptosis, inhibited 33316141 2 6 0 nuclear localization -PCNA PCNA Cell cycle regulation; DNA replication P12004 5111 20p12.3 human Y60-p 38486265 RSEGFDTyRCDRNLA PCNA_N ubiquitination cell cycle regulation 28924044 1 1 0 -STMN1 STMN1 Cytoskeletal P16949 3925 1p36.11 human S16-p 448554 KELEKRAsGQAFELI Stathmin molecular association, regulation; activity, inhibited; phosphorylation cell cycle regulation; carcinogenesis, induced; apoptosis, altered; carcinogenesis, inhibited; cell growth, inhibited; apoptosis, induced; cell motility, inhibited; signaling pathway regulation; cell growth, induced; cytoskeletal reorganization TUBA1A(DISRUPTS); TUBA4A(DISRUPTS); TACC3(INDUCES); TUBB(DISRUPTS) 10913145; 11015208; 14645234; 16554300; 19359244; 20110360; 21768358; 26317901; 27041561; 30786936; 31546234; 36221072; 7775478; 9271428 38 98 61 -WT1 WT1 C2H2-type zinc finger protein; DNA-binding; Nucleolus; Transcription factor; Tumor suppressor P19544 7490 11p13 human S393-p 451121 KTCQRKFsRSDHLKT zf-C2H2 transcription, altered 9366517 1 0 0 Phosphorylation of S365 and S393 inhibited WT1 DNA-binding, and thereby decreased WT1 transcriptional repression activity. -RFC1 RFC1 DNA replication P35251 5981 4p14 human T506-p 2915401 KESKLERtPQKNVQG molecular association, regulation PCNA(DISRUPTS) 12930972 1 12 10 -HMGCR HMGCR EC 1.1.1.34; Endoplasmic reticulum; Membrane protein, integral; Membrane protein, multi-pass; Motility/polarity/chemotaxis; Oxidoreductase; Secondary Metabolites Metabolism - terpenoid backbone biosynthesis Q1W675 100144446 pig S869-p 448568 SHMIHNRsKINLQDL signaling pathway regulation 23799098 5 11 0 simvastatin-induced signaling for the closure of K-ATP channel -SMURF2 SMURF2 EC 6.3.2.-; EC 6.3.2.19; Ligase; UBIQUITIN LIGASE; Ubiquitin conjugating system; Ubiquitin ligase Q9HAU4 64750 17q23.3-q24.1 human S384-p 1870790704 KILRQELsQQQPQAG molecular association, regulation; enzymatic activity, induced DNA repair, altered RNF20(INDUCES) 33097595 1 1 0 DNA repair delayed, -MITF MITF DNA-binding; Oncoprotein; Transcription factor O75030 4286 3p13 human S180-p 450264 PGSSAPNsPMAMLTL MITF_TFEB_C_3_N protein degradation; ubiquitination carcinogenesis, induced; cell motility, induced; cell growth, induced 10694430; 36268034 16 1 0 -PAWR PAR-4 Apoptosis Q96IZ0 5074 12q21.2 human T163-p 456964 LREKRRStGVVNIPA signaling pathway regulation 31834925 3 1 31 -SYMPK Symplekin Motility/polarity/chemotaxis; RNA processing Q92797 8189 19q13.32 human T1257-p 3208452 VGEDAMKtPSPAAED intracellular localization cell growth, induced; transcription, induced 28630428 1 24 7 nuclear accumulation, TJ localization -STAT3 STAT3 DNA-binding; Motility/polarity/chemotaxis; Nuclear receptor co-regulator; Transcription factor P40763 6774 17q21.2 human T622-p 1877503800 KEGGVTFtWVEKDIS SH2 molecular association, regulation; activity, inhibited carcinogenesis, inhibited; cell growth, inhibited; transcription, inhibited STAT3(INDUCES) 35722967 1 0 0 -FANCA FANCA DNA repair, damage O15360 2175 16q24.3 human T351-p 11076033 REWSFARtHPLLTSL Fanconi_A_N cell cycle regulation; cytoskeletal reorganization 23806870 1 0 1 maintenance of centrosomal integrity -CDC25A CDC25A EC 3.1.3.48; Motility/polarity/chemotaxis; PHOSPHATASE; Protein phosphatase, dual-specificity P30304 993 3p21.31 human T507-p 450483 KFRTKSRtWAGEKSK molecular association, regulation; enzymatic activity, inhibited; activity, inhibited apoptosis, altered 14-3-3 beta(INDUCES); CCNA1(DISRUPTS); CDK2(DISRUPTS); CDK1(DISRUPTS); CCNB1(DISRUPTS) 14559997; 20368335 4 2 0 -Cebpb C/EBP-beta DNA-binding; Motility/polarity/chemotaxis; Transcription factor P21272 24253 3q42 rat Y109-p 13373503 KKPSDYGyVSLGRAG molecular association, regulation cell growth, induced; transcription, induced DNA(INDUCES) 20351173 1 4 12 -Il21r IL21R Membrane protein, integral; Receptor, cytokine Q9JHX3 60504 7|7 F3 mouse Y510-p 475069 DEGPPRSyLRQWVVR phosphorylation cell growth, altered 17234735 1 0 0 -ALKBH5 ALKBH5 DEMETHYLASE; DNA repair, damage; Demethylase; EC 1.14.11.-; Membrane protein, integral; Oxidoreductase; RNA-binding Q6P6C2 54890 17p11.2|17p11.2 human K132-ac 11323057 DRAPLRNkYFFGEGY 2OG-FeII_Oxy_2 enzymatic activity, induced 32989163 0 3 1 -Grm5 mGluR5 GPCR, family 3; Membrane protein, integral; Membrane protein, multi-pass; Receptor, GPCR P31424 24418 1q32 rat S839-p 455778 VRSAFTTsTVVRMHV activity, induced 15894802 1 5 2 Phosphorylation increases calcium oscillations. Not T840 as believed in a previous paper (mutation of T840D decreases the phosphorylation of S839 though). -TJP2 ZO2 Adaptor/scaffold; Motility/polarity/chemotaxis Q95168 403854 dog S369-p 9730701 QLVVLRDsKQTLINI intracellular localization 19625451; 23804652 2 2 0 -Cacng2 Stargazin Channel, calcium; Membrane protein, integral; Membrane protein, multi-pass Q71RJ2 84347 7q34 rat S239-p 455315 RYQRRSRsSSRSTEP molecular association, regulation neural plasticity PSD-95(INDUCES) 25843401 7 0 0 -Card11 CARD11 Adaptor/scaffold Q8CIS0 108723 5|5 G2 mouse S649-p 457638 NLMLRKFsLERPFRP activity, inhibited apoptosis, altered; cell growth, altered 19917688 5 4 3 -RPAP3 RPAP3 Unknown function Q9H6T3 79657 12q13.11 human S121-p 1279825 SLSQESEsEEDGIHV molecular association, regulation 35129352 1 24 9 inhibits binding to ribosomal proteins and biogenesis factors associated with small (40S) and large (60S) subunits of the ribosome -Nfatc2 NFAT1 DNA-binding; Transcription factor Q60591 18019 2 H3|2 88.91 cM mouse S173-p 447840 PLCLSPAsSGSSASF transcription, inhibited 11030334 0 1 0 -Cdk5r1 CDK5R1 Protein kinase, regulatory subunit P61809 12569 11 B5|11 47.94 cM mouse S91-p 12607404 ENLKKSLsCANLSTF protein degradation 28566287 4 0 0 -SMN1 SMN RNA processing; RNA-binding Q16637 6606 5q13.2 human Y109-p 1016077 WSEDGCIyPATIASI SMN molecular association, regulation; intracellular localization coilin(INDUCES) 24602413 1 2 0 -NDE1 NUDE1 iso1 Cell cycle regulation; Cytoskeletal; Microtubule-binding Q9NXR1-1 54820 16p13.11 human T131-p 20609200 LERAKRAtIMSLEDF molecular association, regulation; protein conformation cytoskeletal reorganization NDEL1(INDUCES); PAFAH1B1(DISRUPTS) 21677187 1 0 0 phosphomimetic mutant inhibits neurite extension -PKD2 PKD2 Channel, cation; Membrane protein, integral; Membrane protein, multi-pass Q13563 5311 4q22.1 human S812-p 451598 FPRSLDDsEEDDDED activity, induced; molecular association, regulation PACS2(INDUCES); CBY1(DISRUPTS) 14742446; 23838289 3 24 8 -GHRL ghrelin Apoptosis; Cell cycle regulation; Cell development/differentiation; Secreted; Secreted, signal peptide Q9UBU3 51738 3p25.3 human S41-p 2235100 RVQQRKEsKKPPAKL Motilin_ghrelin intracellular localization; protein conformation 18343535 1 0 0 disrupts ghrelin structure and its binding to membranes -CRYAA CRYA1 Chaperone; Heat shock protein P02489 1409 21q22.3 human K99-ac 7482009 DFVEIHGkHNERQDD HSP20 activity, induced; molecular association, regulation; protein conformation 22120592 1 3 0 increased chaperone function with client proteins -UNG UNG EC 3.2.2.27; Hydrolase P13051 7374 12q24.11 human S64-p 2018601 EPGTPPSsPLSAEQL protein degradation; molecular association, regulation; ubiquitination; protein conformation; enzymatic activity, induced DNA repair, induced RPA1(DISRUPTS) 18079698; 27875297 3 19 14 -PML PML Nucleolus; Oncoprotein; SUMO LIGASE; SUMO conjugating system; SUMO ligase; Transcription factor; Tumor suppressor; Ubiquitin conjugating system P29590 5371 15q24.1 human S560-p 6835504 EERVVVIsSSEDSDA DUF3583 molecular association, regulation SUMO2(INDUCES); SUMO1(INDUCES); SUMO3(INDUCES) 19217413; 19380586 2 6 0 PML interaction with SUMO-modified protein partners and PML nuclear bodies maturation -NCOA3 SRC-3 ACETYLTRANSFERASE; Acetyltransferase; EC 2.3.1.48; Motility/polarity/chemotaxis; Nuclear receptor co-regulator; Transcription, coactivator/corepressor Q9Y6Q9 8202 20q13.12 human T24-p 454110 KRKLPCDtPGQGLTC molecular association, regulation carcinogenesis, induced; cell growth, induced; transcription, induced ER-alpha(DISRUPTS) 15383283; 23850489; 33542078 5 1 0 -Prdx6 PRDX6 Amino Acid Metabolism - phenylalanine; EC 1.11.1.15; EC 1.11.1.9; Energy Metabolism - methane; Oxidoreductase; Phospholipase O35244 94167 13q22 rat T177-p 3823356 TASNPVAtPVDWKKG 1-cysPrx_C enzymatic activity, induced 19140803 4 5 12 in vitro -BCL2L11 BIM Apoptosis O43521 10018 2q13 human K112-ub 25087002 PAPMSCDkSTQTPSP protein degradation apoptosis, inhibited 14657036 2 0 0 -Map3k2 MEKK2 EC 2.7.11.25; KINASE; Kinase, protein; Protein kinase, STE; Protein kinase, Ser/Thr (non-receptor) Q61083 26405 18|18 B1 mouse S153-p 3216819 AERKKRLsVVGPPNR signaling pathway regulation 16581779 3 51 11 cAMP-regulated growth factor receptor signaling -Prkcb PKCB EC 2.7.11.13; KINASE; Kinase, protein; Motility/polarity/chemotaxis; Protein kinase, AGC; Protein kinase, Ser/Thr (non-receptor) P68404 18751 7 F2|7 65.75 cM mouse Y662-p 455926 NEFAGFSyTNPEFVI Pkinase_C molecular association, regulation GRB2(INDUCES) 12881490 1 0 0 -IKBKE IKKE EC 2.7.11.10; Inhibitor; KINASE; Kinase, protein; Protein kinase, Other; Protein kinase, Ser/Thr (non-receptor) Q14164 9641 1q32.1 human S172-p 447631 DDDEKFVsVYGTEEY Pkinase enzymatic activity, induced 11839743; 23478265; 27346349 8 4 0 T cell activation -BRCA1 BRCA1 EC 6.3.2.-; Nuclear receptor co-regulator; Transcription, coactivator/corepressor; Tumor suppressor; UBIQUITIN LIGASE; Ubiquitin conjugating system; Ubiquitin ligase P38398 672 17q21.31 human S114-p 18007298 FAKKENNsPEHLKDE molecular association, regulation; intracellular localization DNA repair, induced PIN1(INDUCES); RAD51(INDUCES) 31270457 1 15 1 -Vim Vimentin Cytoskeletal; Motility/polarity/chemotaxis P20152 22352 2 A1|2 10.04 cM mouse S5-p 471086 ___MSTRsVSSSSYR molecular association, regulation endocytosis, induced JAG1(INDUCES) 28533359 3 10 3 transendocytosis -AFF1 AF-4 Oncoprotein; Transcription factor P51825 4299 4q21.3-q22.1 human S212-p 3191671 PSPVPPLsPIHSNQQ AF-4 protein degradation; molecular association, regulation; intracellular localization transcription, induced 14-3-3 theta(INDUCES); CDK9(INDUCES) 21574958 1 28 6 nuclear import-export -GAS2L1 GAS2L1 Cytoskeletal Q99501 10634 22q12.2 human S352-p 1974202 HPRSRRYsGDSDSSA molecular association, regulation; protein conformation cell cycle regulation; chromatin organization, altered MICAL1(INDUCES) 32289147 1 13 2 centrosome seperation increase F-actin binding activity -NFATC3 NFAT4 DNA-binding; Transcription factor Q12968 4775 16q22.1 human T204-p 11507601 NEAAARFtLGSPLTS intracellular localization 9630228 1 0 0 cytoplasmic localization (inhibition of nuclear localization) -Lpp LPP Adaptor/scaffold; Cytoskeletal; Motility/polarity/chemotaxis Q8BFW7 210126 16|16 B1 mouse Y298-p 449713 TSNQGRYyEPYYAAG cell cycle regulation; cell motility, altered 18515860 1 7 43 -RC3H2 MNAB DNA-binding; UBIQUITIN LIGASE; Ubiquitin conjugating system; Ubiquitin ligase Q9HBD1 54542 9q33.2 human Y691-p 1253812003 PPVPSGMyAPVYDSR protein stabilization; molecular association, regulation; ubiquitination KLHL6(DISRUPTS) 30209976 1 0 0 phosphorylation inhibits ubiquitin mediated degradation -Arrb1 ARRB1 Adaptor/scaffold P29066 25387 1q32 rat Y54-p 458023 YLKERRVyVTLTCAF Arrestin_N molecular association, regulation; receptor internalization, altered AP3M1(DISRUPTS) 17456469 1 1 1 decreases beta 2 adrenergic receptor internalization -Rptor Raptor Adaptor/scaffold Q8K4Q0 74370 11|11 E2 mouse S863-p 453732 LTQSAPAsPTNKGMH molecular association, regulation signaling pathway regulation PRAS40(INDUCES); p70S6K(INDUCES) 24239769 13 101 6 mechanical stress-induced mTOR signaling -CDC20 CDC20 Cell cycle regulation; Ubiquitin conjugating system Q12834 991 1p34.2 human T70-p 455844 SSSKVQTtPSKPGGD activity, inhibited cell cycle regulation 29084198; 33819340 2 23 7 -EPOR EPOR Membrane protein, integral; Receptor, cytokine P19235 2057 19p13.2 human Y468-p 451266 DSGISTDySSGDSQG apoptosis, inhibited 14662339 3 0 0 -GABRA4 GABRA4 Channel, chloride; Channel, ligand-gated; Membrane protein, integral; Membrane protein, multi-pass; Transporter; Transporter, ion channel P48169 2557 4p12 human S474-p 17390700 KASVGSAsTRHVFGS Neur_chan_memb protein stabilization; intracellular localization endocytosis, induced 20940303; 24778259 2 1 0 membrane insertion of receptor complex; increases receptor cell surface expression -Crtc2 TORC2 Transcription, coactivator/corepressor Q3LRZ1 310615 2q34 rat S171-p 454622 SALNRTSsDSALHTS TORC_M activity, induced 32020874 19 10 12 -Gphn gephyrin Adaptor/scaffold; EC 2.10.1.1; EC 2.7.7.75 Q03555 64845 6q24 rat S290-p 3213525 SPRAQATsRLSTASC molecular association, regulation gephyrin(INDUCES) 22778260 2 2 1 oligomerization -OTUB1 OTUB1 DEUBIQUITINASE; EC 3.4.19.12; Protease; Ubiquitin conjugating system; Ubiquitin-specific protease Q96FW1 55611 11q13.1 human K122-m1 1883522702 KAVSAKSkEDLVSQG molecular association, regulation UBE2N(DISRUPTS) 36822329 1 1 0 methylation of OTUB1 relieves the suppressive role of OTUB1 on ferroptosis -RAPH1 RAPH1 Adaptor/scaffold; Motility/polarity/chemotaxis Q70E73 65059 2q33.2 human S1071-p 1883958002 FPSPPSDsDFPPPPP intracellular localization cell motility, induced VASP(DISRUPTS) 37632751 1 1 0 regulates MENA localization -Ghr GH receptor Membrane protein, integral; Receptor, cytokine P16310 25235 2q16 rat Y338-p 455508 DNYKPDFyNDDSWVE GHBP molecular association, regulation SOCS3(INDUCES) 10585430 2 0 0 -DYRK2 DYRK2 iso2 EC 2.7.12.1; KINASE; Kinase, protein; Protein kinase, CMGC; Protein kinase, dual-specificity (non-receptor) Q92630-2 8445 12q15 human T82-p 1874397808 KVKATPMtPEQAMKQ intracellular localization cell cycle regulation; apoptosis, induced 34363019 1 1 0 -PML PML Nucleolus; Oncoprotein; SUMO LIGASE; SUMO conjugating system; SUMO ligase; Transcription factor; Tumor suppressor; Ubiquitin conjugating system P29590 5371 15q24.1 human S403-p 3189643 AAVSKKAsPEAASTP DUF3583 carcinogenesis, altered 20832753 1 44 44 -LGALS3 galectin-3 Cell surface; Extracellular matrix; Motility/polarity/chemotaxis P17931 3958 14q22.3 human Y107-p 14823408 AYPATGPyGAPAGPL activity, induced; protein processing; protein conformation cell motility, induced; cell motility, altered 20600357; 22232548; 24269589 3 0 0 regulates cell morphology; prevents galectin-3 cleavage; Phosphorylation of S6 and S12 In N-terminal promotes association with carbohydrate recognition domain (CRD), while phosphorylation of Y107 and Y118 attenuates this interaction. -IRF6 IRF6 DNA-binding; Transcription factor O14896 3664 1q32.2 human S413-p 18911095 FSGDFTRsFDSGSVR activity, induced; protein conformation transcription, induced 24872416; 25246526 3 3 0 -Phldb2 PHLDB2 Vesicle Q8K1N2 208177 16|16 B5 mouse S465-p 483335 KPEGRRLsAGTTVAD protein degradation 31775047 1 37 26 -NPM/ALK NPM-ALK KINASE; Kinase, protein; Protein kinase, TK; Protein kinase, tyrosine (receptor) AAA58698 human S135-p 27275118 AMQMELQsPEYKLSK phosphorylation carcinogenesis, altered; cell growth, altered 21045017 1 1 0 -ANXA1 ANXA1 Calcium-binding; Lipid-binding P04083 301 9q21.13 human K312-ac 461553 EIDMNDIkAFYQKMY Annexin protein degradation; molecular association, regulation; intracellular localization; phosphorylation autophagy, induced PKAR2B(INDUCES) 34601098 1 8 31 autophagy induced to degrade PRKAR2B; reduced caspase-3 and caspase-9 activity by increasing phosphorylation level of caspase-9 -HSF1 HSF1 DNA-binding; Transcription factor Q00613 3297 8q24.3 human S419-p 455264 SALLDLFsPSVTVPD Vert_HS_TF carcinogenesis, induced; cell growth, induced 35906200 5 1 0 -SPAG9 JIP4 Adaptor/scaffold; Cancer Testis Antigen (CTA) O60271 9043 17q21.33 human T217-p 449392 PAGDGLLtPDAQKGG molecular association, regulation autophagy, induced mucolipin 1(INDUCES); ALG2(INDUCES) 36394115 1 58 42 -BANF1 BAF DNA-binding O75531 8815 11q13.1 human S4-p 458302 ____MTTsQKHRDFV BAF molecular association, regulation; intracellular localization; protein conformation cell cycle regulation lamin A/C(DISRUPTS); BAF(DISRUPTS) DNA(INDUCES); DNA(DISRUPTS) 16371512; 16495336; 24265311; 24600006; 24945635; 25899223; 33744941; 36402223 9 19 0 -Grin2a NMDAR2A Channel, ligand-gated; Membrane protein, integral; Membrane protein, multi-pass P35436 14811 16 A1|16 5.28 cM mouse Y1325-p 458211 RLLEGNLyGSLFSVP NMDAR2_C activity, induced; phosphorylation neural plasticity; cell adhesion, induced 19834457; 33975959; 35536885 8 2 84 -PDPK1 PDK1 EC 2.7.11.1; KINASE; Kinase, protein; Nuclear receptor co-regulator; Protein kinase, AGC; Protein kinase, Ser/Thr (non-receptor) O15530 5170 16p13.3 human S396-p 448582 SSSSSSHsLSASDTG intracellular localization transcription, altered 15743829 4 1 0 regulates nuclear accumulation and inhibits transcription through FOXO3a -NCL NCL DNA-binding; Helicase; Nuclear receptor co-regulator; Nucleolus; RNA-binding P19338 4691 2q37.1 human T641-p 21697920 EIDGNKVtLDWAKPK RRM_1 molecular association, regulation; protein stabilization carcinogenesis, induced; cell growth, induced; RNA stability, induced; translation, induced RNA(INDUCES) 21998300; 25173817 2 0 1 induces binding to Sp1 RNA and IRES-mediated Sp1 expression -NPM1 NPM1 Nucleolus; Oncoprotein; RNA-binding; Translation P06748 4869 5q35.1 human T199-p 448515 VKKSIRDtPAKNAQK protein degradation; acetylation; molecular association, regulation; ubiquitination; intracellular localization; activity, inhibited cell cycle regulation; carcinogenesis, induced; transcription, inhibited MDM2(DISRUPTS) RNA(DISRUPTS) 12058066; 18165222; 20333249; 20713529; 24998852; 26993766; 30453269; 32076484; 32092641 24 29 30 -UNG UNG EC 3.2.2.27; Hydrolase P13051 7374 12q24.11 human T60-p 452622 AGQEEPGtPPSSPLS protein degradation; molecular association, regulation; ubiquitination; phosphorylation; enzymatic activity, induced DNA repair, induced RPA1(DISRUPTS) 18079698; 27875297 2 37 35 -ADD2 ADD2 Cytoskeletal; Motility/polarity/chemotaxis P35612 119 2p13.3 human S693-p 454590 SVTSGPMsPEGSPSK phosphorylation 21606488 1 16 0 CDK5 primes sites for phosphorylation by GSK3B -WEE1 Wee1 EC 2.7.10.2; KINASE; Kinase, protein; Protein kinase, Other; Protein kinase, Ser/Thr (non-receptor); Protein kinase, tyrosine (non-receptor) P30291 7465 11p15.4 human S212-p 25316778 SVKLRGSsLFMDTEK protein degradation; molecular association, regulation BTRC(INDUCES) 24817118 1 1 1 -DAXX DAXX Apoptosis; Nuclear receptor co-regulator; Nucleolus; Transcription, coactivator/corepressor Q9UER7 1616 6p21.32 human K630-sm 2407410 GDSGPPCkKSRKEKK molecular association, regulation; intracellular localization cell growth, inhibited; transcription, inhibited PML(INDUCES) 16818774 4 0 0 -PRKCE PKCE EC 2.7.11.13; KINASE; Kinase, protein; Protein kinase, AGC; Protein kinase, Ser/Thr (non-receptor) Q02156 5581 2p21 human T349-p 486054 DRSKSAPtSPCDQEI molecular association, regulation 14-3-3 zeta(DISRUPTS) 34143863 1 4 0 -KAT7 MYST2 ACETYLTRANSFERASE; Acetyltransferase; EC 2.3.1.48; Nuclear receptor co-regulator; Transcription, coactivator/corepressor O95251 11143 17q21.33 human S53-p 460901 SARLSQSsQDSSPVR protein degradation; molecular association, regulation; ubiquitination cell cycle regulation; cell growth, inhibited DDB2(INDUCES) 26572825 1 20 29 -DDB1 DDB1 DNA repair, damage Q16531 1642 11q12.2 human Y316-p 62873404 SIAECLTyLDNGVVF MMS1_N molecular association, regulation DDA1(INDUCES) 28087699 1 0 0 ubiquitination of CRL4 substrates -RBL2 Rb-like 2 Transcription, coactivator/corepressor; Tumor suppressor Q08999 5934 16q12.2 human S413-p 449724 VRYIKENsPCVTPVS molecular association, regulation cell cycle regulation E2F4(DISRUPTS) 11157749; 12006580 3 19 2 -PHLPP1 PHLPP EC 3.1.3.16; PHOSPHATASE; Protein phosphatase, Ser/Thr (non-receptor); Tumor suppressor O60346 23239 18q21.33 human S450-p 36134756 VAPGGLQsTPGRSGV cell cycle regulation 33397691 1 2 0 -CETN1 CETN1 Q12798 1068 18p11.32 human T138-p 34405000 NELGENLtDEELQEM EF-hand_7 molecular association, regulation G-beta 1(DISRUPTS); SFI1(DISRUPTS) 24918055 1 0 0 -TIAM1 TIAM1 GEF; GEF, Rac/Rho; Motility/polarity/chemotaxis; Oncoprotein Q13009 7074 21q22.11 human T340-p 35524907 DSGIEGAtTDTDLLS molecular association, regulation BTRC(INDUCES) 25124033 1 1 0 -GABBR1 GABBR1 GPCR, family 3; Membrane protein, integral; Membrane protein, multi-pass; Receptor, GPCR Q9UBS5 2550 6p22.1 human Y404-p 1875398100 ADNWFKIyDPSINCT ANF_receptor molecular association, regulation; phosphorylation carcinogenesis, induced; cell growth, induced; signaling pathway regulation PTP-PEST(INDUCES) 34778730 1 0 0 binding to PTP-PEST inhibits PTP-PEST binding to EGFR, induces EGFR phosphorylation, thus regulating AKT signaling -Zdhhc3 ZDHHC3 EC 2.3.1.225; Membrane protein, integral; Membrane protein, multi-pass; Transferase Q8R173 69035 9|9 F4 mouse Y18-p 462842 DIERKPEyLQPEKCA enzymatic activity, induced cytoskeletal reorganization 27247265 1 0 20 neurite outgrowth; palmitoylation -PSEN1 PSEN1 Cell surface; EC 3.4.23.-; Membrane protein, integral; Membrane protein, multi-pass; Mitochondrial; Protease P49768 5663 14q24.2 human S346-p 450179 EWEAQRDsHLGPHRS Presenilin apoptosis, inhibited 14576165 1 0 1 Phosphorylation at S346 regulates the caspase-mediated cleavage of PS1 and inhibits progression of apoptosis. -RAB11A RAB11A G protein; G protein, monomeric; G protein, monomeric, Rab; Motility/polarity/chemotaxis P62491 8766 15q22.31 human K145-ub 15395883 EARAFAEkNGLSFIE Ras receptor recycling, induced; enzymatic activity, induced 24190883 1 1 5 -CSNK1E CK1E EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, CK1; Protein kinase, Ser/Thr (non-receptor) P49674 1454 22q13.1 human T325-p 453417 GQLRGSAtRALPPGP enzymatic activity, inhibited 10542239; 12223474 2 1 1 some subset of these 8 sites -Pitx2 PITX2 Cell cycle regulation; DNA-binding; Motility/polarity/chemotaxis; Transcription factor P97474 18741 3 G3|3 57.84 cM mouse T90-p 25790902 KRQRRQRtHFTSQQL Homeodomain molecular association, regulation cell growth, inhibited; cell differentiation, induced; RNA stability, inhibited 14-3-3 zeta(INDUCES); HuR(DISRUPTS) 20019746 1 0 0 -SLC43A2 SLC43A2 Membrane protein, integral; Membrane protein, multi-pass; Transporter; Transporter, SLC family Q8N370 124935 17p13.3 human S274-p 2508983 TTVGRRLsVGSSMRS MFS_1 protein stabilization; intracellular localization; activity, inhibited 30379325 2 28 1 membrane localization & transport activity decreased, leades to mature, core-glycosylated form, regulation of amino acid absorption -AIP AIP Nuclear receptor co-regulator; Transcription, coactivator/corepressor O00170 9049 11q13.2 human S132-p 10888702 AQMREHSsLGHADLD molecular association, regulation HSP90A(INDUCES) 12361709 2 0 0 -Myocd myocardin Cell development/differentiation; Transcription factor Q8VIM5 214384 11|11 B3 mouse S859-p 10791202 ELLPGPLsPMHAQLS molecular association, regulation transcription, inhibited CBP(DISRUPTS) 19776005 1 0 0 -AURKB AurB EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, Other; Protein kinase, Ser/Thr (non-receptor) Q96GD4 9212 17p13.1 human K202-ub 21129738 KVIHRDIkPENLLLG Pkinase molecular association, regulation; enzymatic activity, induced cell cycle regulation 36473924 2 4 0 formation of CPC complex, required for proper mitotic progression, critical site for cell survival -IRAK1 IRAK1 EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, Ser/Thr (non-receptor); Protein kinase, TKL P51617 3654 Xq28 human S163-p 60189902 PELGLVPsPASLWPP molecular association, regulation PIN1(INDUCES) 27790836 1 0 0 bivalent advantage for Pin1 binding -Mapk7 ERK5 EC 2.7.11.24; KINASE; Kinase, protein; Protein kinase, CMGC; Protein kinase, Ser/Thr (non-receptor) Q9WVS8 23939 11|11 B2 mouse S760-p 14561007 PQDGQADsASLSASL transcription, altered 17928297 2 1 0 -HIF1A HIF1A Autophagy; DNA-binding; Transcription factor Q16665 3091 14q23.2 human S247-p 15434302 KTFLSRHsLDMKFSY molecular association, regulation; activity, inhibited cell cycle regulation; carcinogenesis, altered; transcription, inhibited ARNT(DISRUPTS) 20699359 1 0 0 -CDH1 CDH1 Cell adhesion; Membrane protein, integral; Motility/polarity/chemotaxis; UBIQUITIN LIGASE; Ubiquitin ligase P12830 999 16q22.1 human S840-p 15754600 FDYEGSGsEAASLSS CADH_Y-type_LIR protein stabilization carcinogenesis, altered; cell motility, inhibited 35115926 5 1 0 -Nfatc2 NFAT1 DNA-binding; Transcription factor Q60591 18019 2 H3|2 88.91 cM mouse S56-p 455327 HKAISSPsGLAYPDD transcription, induced 11030334 0 2 0 -Axin1 axin 1 Adaptor/scaffold; Tumor suppressor O35625 12005 17 A3.3|17 13.07 cM mouse S485-p 451092 MRTPGCQsPGPGHRS Axin_b-cat_bind activity, induced 10581160 2 9 6 Phosphorylation plays a role in the activation of axin to modulate Lef/Tcf signaling. Phosphorylation by GSK3beta also leads to increased direct binding of beta-catenin in vitro. -HMGB1 HMGB1 DNA repair, damage; Nuclear receptor co-regulator P09429 3146 13q12.3 human S46-p 33673900 SEFSKKCsERWKTMS HMG_box_2 intracellular localization 24863048 1 0 0 localization into the cytosol -LEPR LEPR Membrane protein, integral; Receptor, cytokine P48357 3953 1p31.3 human Y1141-p 448434 SKKTFASyMPQFQTC transcription, induced; signaling pathway regulation 17726024; 20868760 16 0 0 mediates STAT3 phosphorylation and FZD1 expression -Pde6g PDE6G EC 3.1.4.35; Nucleotide Metabolism - purine; Phosphodiesterase P09174 18588 11 E2|11 84.14 cM mouse T62-p 449335 PGMEGLGtDITVICP PDE6_gamma activity, induced; molecular association, regulation; phosphorylation GRK2(INDUCES) 11502744; 12624098 2 0 0 leads to greater phospho-ERK; increases ERK phosphorylation -FYB1 SLAP-130 Adaptor/scaffold O15117 2533 5p13.1 human Y571-p 454079 TTAVEIDyDSLKLKK molecular association, regulation; intracellular localization; phosphorylation cell motility, induced; cell motility, altered; transcription, induced ZAP70(INDUCES) 20661443; 26246585; 33431658 3 31 774 after CXCR4 stimulation; induces STAT3 phosphorylation; promotes cell migration -Bmal1 BMAL1 iso4 DNA-binding; Transcription factor Q9WTL8-4 11865 7 F1|7 59.17 cM mouse S90-p 7359500 RRRDKMNsFIDELAS HLH molecular association, regulation CK2B(DISRUPTS) 26562092 3 0 0 inhibits CK2A1 binding and phosphorylation, regulates the central and peripheral clocks -RUNX2 AML3 DNA-binding; Transcription factor Q13950 860 6p21.1 human S465-p 460684 MVPGGDRsPSRMLPP RunxI molecular association, regulation cell cycle regulation; cell motility, induced; cell growth, induced; cell differentiation, induced; transcription, altered; cell growth, altered DNA(INDUCES) 16407259; 21913213 5 0 0 -CASS4 HEFL Adaptor/scaffold Q9NQ75 57091 20q13.31 human Y350-p 458181 QNTKPNIyDIPKATS molecular association, regulation Arg(NOT_REPORTED) 23322602 0 5 341 -H2AZ2 H2AFV Q71UI9 94239 7p13 human K7-ac 480255 _AGGKAGkDSGKAKA Histone molecular association, regulation transcription, induced FALZ(INDUCES) 32356653 1 10 321 K7ac preferentially engaging the binding site, acetylation at K7ac and K13ac is also the highest-affinity acetylation pattern of isoform I -ADRB1 ADRB1 GPCR, family 1; Membrane protein, integral; Membrane protein, multi-pass; Receptor, GPCR P08588 153 10q25.3 human S461-p 89117901 GAAADSDsSLDEPCR receptor internalization, induced; molecular association, regulation; intracellular localization ARRB1(INDUCES) 28472170 1 2 0 beta-arrestin recruitment to the ADRB1 -CENPT CENPT DNA replication Q96BT3 80152 16q22.1 human S47-p 11141604 RALLETAsPRKLSGQ CENP-T_N intracellular localization cell cycle regulation 21529714 2 14 2 localization of Ndc80/Hec1, controls kinetochore assembly, increases cell viability -ARMC10 ARMC10 Endoplasmic reticulum; Membrane protein, integral Q8N2F6 83787 7q22.1 human S45-p 454558 LGIRSSKsAGALEEG activity, induced autophagy, induced 30631047 1 72 18 regulates AMPK-mediated mitochondrial dynamics and fission -CNKSR1 CNK1 Adaptor/scaffold; G protein regulator, misc. Q969H4 10256 1p36.11 human S22-p 59070501 WLRGLDDsLQDYPFE SAM_1 molecular association, regulation; protein conformation cell growth, induced Akt1(INDUCES) 27769899 1 1 0 oligomerization, invasion of cancer cells -DDR2 DDR2 EC 2.7.10.1; KINASE; Kinase, protein; Membrane protein, integral; Protein kinase, TK; Protein kinase, tyrosine (receptor) Q16832 4921 1q23.3 human Y740-p 456862 RNLYSGDyYRIQGRA PK_Tyr_Ser-Thr phosphorylation 16186108 2 9 366 Stimulates autophosphorylation. Autophosphorylation induces Shc binding (site not determined). -ANXA2 ANXA2 Calcium-binding; Lipid-binding; Motility/polarity/chemotaxis P07355 302 15q22.2 human S12-p 450880 HEILCKLsLEGDHST molecular association, regulation; intracellular localization exocytosis, inhibited S100A10(DISRUPTS) 11106498; 12962548; 21115493; 23757730 7 29 1 regulates VWF secretion -KCNA3 Kv1.3 Channel, potassium; Membrane protein, integral; Membrane protein, multi-pass P22001 3738 1p13.3 human Y161-p 3820926 PSFDAILyYYQSGGR BTB_2 activity, inhibited 19166614 1 0 0 -HCRTR1 HCRTR1 GPCR, family 1; Membrane protein, integral; Membrane protein, multi-pass; Receptor, GPCR O43613 3061 1p35.2 human Y358-p 2063600 SAANPIIyNFLSGKF 7tm_1; TM apoptosis, induced 18198212 1 0 0 apoptosis is inhibited in cells transfected with dnSHP-2 cDNA or treated with PAO -GLI1 GLI1 C2H2-type zinc finger protein; Oncoprotein; Transcription factor P08151 2735 12q13.3 human S1078-p 1034327202 SGHTPPPsGPPNMAV molecular association, regulation; intracellular localization transcription, inhibited SUFU(INDUCES) DNA(DISRUPTS) 29662197 1 0 0 localized in cytoplasm -FER Fer EC 2.7.10.2; KINASE; Kinase, protein; Oncoprotein; Protein kinase, TK; Protein kinase, tyrosine (non-receptor) P16591 2241 5q21.3 human Y615-p 6311907 EAKILKQyDHPNIVK PK_Tyr_Ser-Thr enzymatic activity, induced 19159681 1 0 1 -Notch2 Notch 2 KINASE; Kinase, protein; Membrane protein, integral; Motility/polarity/chemotaxis; Receptor, misc. Q9QW30 29492 2q34 rat S2090-p 2154600 VLCGPNRsFLSLKHT activity, induced cell differentiation, altered; transcription, altered 11577080 1 1 0 -H1-4 H1E DNA-binding P10412 3008 6p22.2 human S187-p 458354 KPKKAPKsPAKAKAV molecular association, regulation transcription, induced POLR2A(INDUCES) DNA(INDUCES) 33238524 2 20 57 -MYL9 MRLC1 Contractile; Motility/polarity/chemotaxis P24844 10398 20q11.23 human S3-p 4964100 _____MSsKRAKAKT intracellular localization cytoskeletal reorganization 22136066 5 0 0 -GHSR GHSR GPCR, family 1; Membrane protein, integral; Membrane protein, multi-pass; Receptor, GPCR Q92847 2693 3q26.31 human T261-p 25293461 RDQNHKQtVKMLAVV 7tm_1 molecular association, regulation ARRB1(INDUCES); ARRB2(INDUCES) 35605660 1 0 1 -NR4A2 NR4A2 DNA-binding; Nuclear receptor P43354 4929 2q24.1 human S181-p 30304800 SLFSFKQsPPGTPVS intracellular localization 24223135 1 4 0 UV induced nuclear foci formation and co-localization with DNA repair proteins -TERF2 TRF2 DNA repair, damage; DNA-binding Q15554 7014 16q22.1 human T230-p 456963 HMSKDPTtQKLRNDL TRF intracellular localization 16223874 3 1 0 TRF2 T188 localizes to telomeres iin crisis and associates with Double stranded breaks in photo-induced cells. -CANX Calnexin Calcium-binding; Endoplasmic reticulum; Membrane protein, integral; Motility/polarity/chemotaxis P24643 dog S565-p 456360 EEDGGTAsQEEDDRK molecular association, regulation; intracellular localization PACS2(DISRUPTS) 18417615 7 85 48 -Ppp1r9b Spinophilin Adaptor/scaffold; Protein phosphatase, regulatory subunit Q6R891 217124 11|11 D mouse S15-p 455339 GPGGPLRsASPHRSA cytoskeletal reorganization 15728359 1 0 0 -Irs1 IRS1 Adaptor/scaffold; Motility/polarity/chemotaxis P35570 25467 9q34 rat S612-p 447562 DDGYMPMsPGVAPVP molecular association, regulation; enzymatic activity, inhibited PIK3R2(DISRUPTS); PIK3R1(DISRUPTS) 16354680; 8626671 37 7 4 -RPS10 RPS10 Nucleolus; RNA-binding; Ribosomal; Translation P46783 6204 6p21.31 human K139-ub 486966 VPPGADKkAEAGAGS translation, altered 32324387 2 11 138 translational read-through of poly(A) mRNA sequence (KAAA) 20, ZNF598 plays a role in this process -LCOR LCOR iso3 Nuclear receptor co-regulator Q96JN0-3 84458 10q24.1 human K1241-m3 1881561800 RLKKHLKkFPGATPA molecular association, regulation; enzymatic activity, induced 34321472 1 1 0 LCOR K1241 is required in order to enhance the HMTase activity of PRC2, binds to the aromatic cage of the regulatory subunit EED to stimulate PRC2 -ZKSCAN3 ZNF306 C2H2-type zinc finger protein; DNA-binding; Transcription factor Q9BRR0 80317 6p22.1 human K148-ac 1881852002 GQELLCCkMALLTPA intracellular localization autophagy, inhibited; transcription, inhibited 35124181 1 0 0 translocate to nucleus, autophagy-lysosomal inhibition -LRRK2 LRRK2 EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, Ser/Thr (non-receptor); Protein kinase, TKL Q5S007 120892 12q12 human S910-p 4725893 LVKKKSNsISVGEFY protein stabilization; molecular association, regulation; ubiquitination; enzymatic activity, inhibited; intracellular localization; phosphorylation 14-3-3 beta(INDUCES); 14-3-3 sigma(INDUCES); 14-3-3 theta(INDUCES); 14-3-3 zeta(INDUCES); 14-3-3 epsilon(INDUCES); 14-3-3 gamma(INDUCES); 14-3-3 eta(INDUCES) 20642453; 20659021; 21378983; 22004453; 24942733; 25009464; 32317922; 34144124; 35266954 22 17 0 -Mapk10 JNK3 EC 2.7.11.24; KINASE; Kinase, protein; Protein kinase, CMGC; Protein kinase, Ser/Thr (non-receptor) P49187 25272 14p22 rat T131-p 448033 ISLLNVFtPQKTLEE Pkinase apoptosis, induced 11823425 1 0 0 -Cebpb C/EBP-beta DNA-binding; Motility/polarity/chemotaxis; Transcription factor P28033 12608 2 H3|2 87.58 cM mouse K211-ac 1881371303 GPPAAPAkAKAKKTV protein degradation 34642310 1 1 0 SIRT2 decreases acetylation and ubiquitylation (not at K102 site) ; under ethanol stress -Camk2b CAMK2B EC 2.7.11.17; KINASE; Kinase, protein; Protein kinase, CAMK; Protein kinase, Ser/Thr (non-receptor) P08413 24245 14q21 rat T381-p 2020833 PAALEPQtTVIHNPV molecular association, regulation 26291163 1 2 1 inhibits interaction with F-actin, regulates synaptic plasticity -Lrp6 LRP6 Membrane protein, integral; Receptor, misc. O88572 16974 6 G1|6 65.37 cM mouse T1572-p 3802448 EPVPPPPtPRSQYLS signaling pathway regulation 24692544 5 0 8 Wnt signaling -Ctnnd1 CTNND1 Actin-binding; Adaptor/scaffold; Cell adhesion; G protein regulator, misc.; Motility/polarity/chemotaxis P30999 12388 2 D|2 49.45 cM mouse Y112-p 472275 PGQIVETyTEEDPEG molecular association, regulation cytoskeletal reorganization RHOA(DISRUPTS); CDH1(INDUCES) 17194753 3 0 0 resposible for the dendritic phenotype in fibroblasts; decreases the amount of active RhoA -RUNX1 AML1 DNA-binding; Oncoprotein; Transcription factor Q01196 861 21q22.12 human S249-p 454399 DTRQIQPsPPWSYDQ activity, induced; molecular association, regulation; phosphorylation transcription, altered; cell growth, altered CBFB(INDUCES) 18695000; 8668214 10 8 46 -ERBB4 HER4 EC 2.7.10.1; KINASE; Kinase, protein; Membrane protein, integral; Protein kinase, TK; Protein kinase, tyrosine (receptor) Q15303 2066 2q34 human S1051-p 1869951802 NRSEIGHsPPPAYTP enzymatic activity, inhibited signaling pathway regulation 31053301 1 0 0 MEK-ERK pathway-dependent feedback inhibition of HER4 activation -FGFR2 FGFR2 EC 2.7.10.1; KINASE; Kinase, protein; Membrane protein, integral; Oncoprotein; Protein kinase, TK; Protein kinase, tyrosine (receptor) P21802 2263 10q26.13 human Y657-p 472825 DINNIDYyKKTTNGR PK_Tyr_Ser-Thr carcinogenesis, induced; cell growth, induced 35428876 2 6 36 -Fis1 FIS1 Membrane protein, integral; Mitochondrial Q9CQ92 66437 5|5 G2 mouse T34-p 1876807204 AGSVSKStQFEYAWC Fis1_TPR_N molecular association, regulation; intracellular localization apoptosis, induced DRP1(INDUCES) 35290083 1 0 0 -WDR62 WDR62 Adaptor/scaffold O43379 284403 19q13.12 human T50-p 1246205 RRRTRLStASEETVQ cell cycle regulation 25501809; 26713495 2 16 213 WDR62 regulation of the mitotic spindle; S49/T50 is critical for spindle alignment and mitotic integrity; microtubule association -SH2D2A TSAd Adaptor/scaffold Q9NP31 9047 1q23.1 human Y290-p 449441 PDEPIAFyAMGRGSP molecular association, regulation Lck(INDUCES) 18541536 1 3 129 -PIP5K1C PIP5K1C Carbohydrate Metabolism - inositol phosphate; EC 2.7.1.68; Kinase, lipid; Motility/polarity/chemotaxis O60331 23396 19p13.3 human Y639-p 486321 DAPATDIyFPTDERS carcinogenesis, induced; cell motility, induced; cell growth, induced 25486426 3 0 0 Establishment of tumor favorable microenvironment -BCR/ABL BCR-ABL1 EC 2.7.10.2; Fusion protein; KINASE; Kinase, protein; Protein kinase, TK; Protein kinase, tyrosine (non-receptor) A9UF07 human Y177-p 22639318 ADAEKPFyVNVEFHH molecular association, regulation cell growth, induced; transcription, induced GRB2(INDUCES) 8402896 1 3 6 transcription from ets/AP1 -EGFR EGFR EC 2.7.10.1; KINASE; Kinase, protein; Membrane protein, integral; Oncoprotein; Protein kinase, TK; Protein kinase, tyrosine (receptor) P00533 1956 7p11.2 human K754-ub 1065303 LREATSPkANKEILD PK_Tyr_Ser-Thr receptor recycling, inhibited; protein degradation 16543144; 17940017 2 3 0 -NOS3 eNOS Amino Acid Metabolism - arginine and proline; EC 1.14.13.39; Oxidoreductase Q7YSG7 397557 pig T497-p 447885 TGIARKKtFKEVANA enzymatic activity, inhibited 15333638 82 2 1 -NCOA3 SRC-3 ACETYLTRANSFERASE; Acetyltransferase; EC 2.3.1.48; Motility/polarity/chemotaxis; Nuclear receptor co-regulator; Transcription, coactivator/corepressor Q9Y6Q9 8202 20q13.12 human S1033-p 4252802 NRPLLRNsLDDLVGP protein stabilization; molecular association, regulation PSMA3(DISRUPTS) 18313384 1 4 0 some subset of these 8 residues -BTRC BTRC Motility/polarity/chemotaxis; UBIQUITIN LIGASE; Ubiquitin conjugating system; Ubiquitin ligase Q9Y297 8945 10q24.32 human S158-p 1872610002 EFVEHLIsQMCHYQH Beta-TrCP_D protein degradation; protein stabilization; molecular association, regulation; ubiquitination cell cycle regulation; DNA repair, induced FBW1B(INDUCES) 33676897 1 0 0 induces stabilization of itself and regulates ubiquitination and degradation of BTRC2 and MDM2 and stabilization of p53 -Mapt Tau ACETYLTRANSFERASE; Acetyltransferase; Cytoskeletal P19332 29477 10q32.1 rat T492-p 447932 KTTPSPKtPPGSGEP neural plasticity 33648608 107 36 23 -LCOR LCOR iso3 Nuclear receptor co-regulator Q96JN0-3 84458 10q24.1 human K1241-m2 1881559702 RLKKHLKkFPGATPA molecular association, regulation; enzymatic activity, induced 34321472 1 1 0 LCOR K1241 is required in order to enhance the HMTase activity of PRC2, binds to the aromatic cage of the regulatory subunit EED to stimulate PRC2 -EEF2K EEF2K EC 2.7.11.20; KINASE; Kinase, protein; Protein kinase, Ser/Thr (non-receptor); Protein kinase, atypical; Translation O00418 29904 16p12.2 human Y69-p 1877127902 NLTKSERySSSGSPA enzymatic activity, inhibited carcinogenesis, induced; cell growth, induced; translation, induced 35513296 0 1 0 -STIM1 STIM1 Calcium-binding; Endoplasmic reticulum; Membrane protein, integral Q13586 6786 11p15.4 human S668-p 484156 IGEETDSsPGRKKFP molecular association, regulation; intracellular localization; activity, inhibited cytoskeletal reorganization EB1(DISRUPTS) 19881501; 22748319 4 22 3 phosphorylation dissociates STIM1 from EB1 during mitosis, and excludes ER from the mitotic spindle; involved in suppression of store-operated calcium entry during mitosis -Epha4 EphA4 EC 2.7.10.1; KINASE; Kinase, protein; Membrane protein, integral; Protein kinase, TK; Protein kinase, tyrosine (receptor) Q03137 13838 1 C4|1 39.55 cM mouse Y928-p 450651 QAIKMDRyKDNFTAA SAM_2 activity, inhibited cell adhesion, altered 14742708 1 0 0 -Kdr VEGFR2 EC 2.7.10.1; KINASE; Kinase, protein; Membrane protein, integral; Protein kinase, TK; Protein kinase, tyrosine (receptor) P35918 16542 5 C3.3|5 40.23 cM mouse Y1212-p 447902 VCDPKFHyDNTAGIS molecular association, regulation; phosphorylation; enzymatic activity, induced Src(INDUCES) 12023952; 15107818 17 4 58 -CERS5 LASS5 DNA-binding; EC 2.3.1.24; Membrane protein, integral; Membrane protein, multi-pass; Transferase Q8N5B7 91012 12q13.12 human S356-p 18260888 RSDVESSsEEEDVTT enzymatic activity, induced 26887952 1 6 0 -TARBP2 TRBP Motility/polarity/chemotaxis; RNA processing; RNA-binding; Translation Q15633 6895 12q13.13 human S283-p 27457469 ILSLRSCsLGSLGAL protein stabilization; molecular association, regulation transcription, induced P70S6KB(DISRUPTS) 27407113 1 6 0 optimal TRBP expression in human primary cells; miRNA expression -LIN9 LIN9 Cell cycle regulation; Transcription, coactivator/corepressor; Tumor suppressor Q5TKA1 286826 1q42.12 human T96-p 3201645 KFTATMStPDKKASQ cell cycle regulation; transcription, induced 24475316 2 9 15 -SSTR2 SSTR2 GPCR, family 1; Membrane protein, integral; Membrane protein, multi-pass; Receptor, GPCR P30874 6752 17q25.1 human T356-p 12577701 RLNETTEtQRTLLNG receptor internalization, induced; receptor desensitization, induced; receptor recycling, induced 24565897; 24637622 6 0 0 -SERPINA3 SERPINA3 Secreted; Secreted, signal peptide P01011 12 14q32.13 human K236-ac 464673 SRFYLSKkKWVMVPM Serpin molecular association, regulation DNA(INDUCES) 7782318 1 0 0 -Banp BANP Tumor suppressor Q8VBU8 53325 8 E1|8 70.82 cM mouse S370-p 36440208 PTSELQQsQPQALHY molecular association, regulation; intracellular localization cell cycle regulation; DNA repair, induced; apoptosis, inhibited H2AX(INDUCES) 25299772 1 0 0 -Crk CRK Adaptor/scaffold; Motility/polarity/chemotaxis; Oncoprotein Q63768 54245 10q24 rat Y221-p 447951 GGPEPGPyAQPSVNT molecular association, regulation EGFR(DISRUPTS) 9642287 25 14 1168 -SUZ12 SUZ12 C2H2-type zinc finger protein; Oncoprotein; Transcription factor Q15022 23512 17q11.2 human S583-p 4170593 PQEMEVDsEDEKDPE VEFS-Box molecular association, regulation; protein conformation; enzymatic activity, induced cell differentiation, altered; transcription, inhibited H3(INDUCES) DNA(INDUCES) 36351927 1 25 0 induces histone methylation -DCTN1 dynactin 1 Microtubule-binding; Motility/polarity/chemotaxis; Motor Q14203 1639 2p13.1 human S19-p 455515 TPSGSRMsAEASARP intracellular localization cytoskeletal reorganization 23547029 2 1 0 accumulation at spindle poles, required for central spindle assembly -APPL1 APPL Adaptor/scaffold; Nuclear receptor co-regulator Q9UKG1 26060 3p14.3 human S430-p 13204434 ARTSSSGsLGSESTN signaling pathway regulation 22685300 1 2 0 mediates stress-induced insulin resistance -WEE2 WEE1B EC 2.7.10.2; KINASE; Kinase, protein; Protein kinase, Other; Protein kinase, Ser/Thr (non-receptor); Protein kinase, tyrosine (non-receptor) A4PES0 pig S77-p 20473608 PQVKDRAsPDQGLRT intracellular localization; enzymatic activity, induced cell cycle regulation 21123961 1 0 0 -Csf3r GCSFR Membrane protein, integral; Receptor, cytokine P40223 12986 4 D2.2|4 59.77 cM mouse Y768-p 451835 TSPGVMQyIRSDSTQ activity, induced; molecular association, regulation 29572350 5 0 0 STAT3 activation -Rab10 RAB10 G protein; G protein, monomeric; G protein, monomeric, Rab P61027 19325 12 A1.1|12 1.71 cM mouse T73-p 471953 AGQERFHtITTSYYR Ras autophagy, induced; apoptosis, induced; autophagy, inhibited; signaling pathway regulation 37269951; 37454104 18 13 13 -Rb1 Rb Nuclear receptor co-regulator; Oncoprotein; Transcription, coactivator/corepressor; Tumor suppressor P13405 19645 14 38.73 cM|14 D3 mouse T367-p 447982 ANVVTPHtPVRTVMN RB_A molecular association, regulation E2F1(DISRUPTS) 10207050 10 51 40 -PRKCB PKCB EC 2.7.11.13; KINASE; Kinase, protein; Motility/polarity/chemotaxis; Protein kinase, AGC; Protein kinase, Ser/Thr (non-receptor) P05771 5579 16p12.2-p12.1 human S661-p 448672 QNEFAGFsYTNPEFV Pkinase_C intracellular localization; phosphorylation; enzymatic activity, induced transcription, induced 17504762; 35835217 12 1 0 -EHMT2 EHMT2 Amino Acid Metabolism - lysine degradation; EC 2.1.1.43; METHYLTRANSFERASE; Methyltransferase; Methyltransferase, protein lysine Q96KQ7 10919 6p21.33 human K361-sm 1878097302 KPSRKRRkREPPRAK molecular association, regulation; intracellular localization cell cycle regulation; cell growth, induced; transcription, induced PCAF(INDUCES) 30867409 1 0 0 SUMOylated G9a is recruited to E2F1 target gene promoters, EHMT2 is an activator of proliferation and E2F1-target gene expression -PRKAR2B PKAR2B Mitochondrial; Protein kinase, regulatory subunit P31323 5577 7q22.3 human S114-p 452036 NRFTRRAsVCAEAYN protein degradation; enzymatic activity, inhibited; intracellular localization; phosphorylation neural plasticity; transcription, altered 15187164; 33608270; 33649504 5 69 173 inhibits CREB phosphorylation -PAK5 PAK5 EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, STE; Protein kinase, Ser/Thr (non-receptor) Q9P286 57144 20p12.2 human S288-p 1878257802 TMRQRSRsGSGLQEP molecular association, regulation; intracellular localization 14-3-3 sigma(INDUCES) 35969127 1 0 0 -KCNQ1 Kv7.1 Channel, potassium; Membrane protein, integral; Membrane protein, multi-pass P51787 3784 11p15.5-p15.4 human S464-p 456163 SVDGYDSsVRKSPTL activity, induced 12879210 1 1 0 -CGAS cGAS EC 2.7.7.86 Q8N884 115004 6q13 human K384-sm 62952702 LSFSHIEkEILNNHG Mab-21 enzymatic activity, inhibited transcription, inhibited; signaling pathway regulation DNA(DISRUPTS) 28095500 1 0 0 regulation of STING signaling pathway -Met Met EC 2.7.10.1; KINASE; Kinase, protein; Membrane protein, integral; Oncoprotein; Protein kinase, TK; Protein kinase, tyrosine (receptor) P16056 17295 6 A2|6 7.83 cM mouse Y1347-p 448472 STFIGEHyVHVNATY molecular association, regulation cell differentiation, induced; cell motility, altered; cytoskeletal reorganization GRB2(INDUCES); PIK3C2A(INDUCES); GAB1(INDUCES); SHC1(INDUCES) 10069803; 37175792; 7708691 30 6 125 activates cell mobility -MYC Myc DNA-binding; Nucleolus; Oncoprotein; Transcription factor P01106 4609 8q24.21 human K163-ac 460638 AAKLVSEkLASYQAA Myc_N protein stabilization transcription, induced 33928666 4 8 35 -CLSPN claspin Actin-binding; Cell cycle regulation Q9HAW4 63967 1p34.3 human S30-p 467250 EADSPSDsGQGSYET protein degradation; molecular association, regulation cell cycle regulation BTRC(INDUCES) 16885022 1 0 0 claspin degradation is necessary for termination of the DNA replication checkpoint. -CDK5R1 CDK5R1 Protein kinase, regulatory subunit Q15078 8851 17q11.2 human S8-p 471392 MGTVLSLsPSYRKAT molecular association, regulation; protein stabilization; intracellular localization; protein conformation; enzymatic activity, induced cytoskeletal reorganization 17121855; 20976519; 22467861; 26469698 7 0 1 augments its F-actin bundling activity, disrupts microtubule binding -ESR2 ER-beta DNA-binding; Nuclear receptor Q92731 2100 14q23.2-q23.3 human S176-p 23068600 CKAFFKRsIQGHNDY zf-C4 molecular association, regulation transcription, induced DNA(DISRUPTS) 22266331; 34147032 2 1 0 -Trpv1 TRPV1 Channel, cation; Membrane protein, integral; Membrane protein, multi-pass; Receptor, misc. O35433 83810 10q24 rat S502-p 450016 YFLQRRPsLKSLFVD Ion_trans activity, induced; receptor desensitization, inhibited; receptor desensitization, altered RNUXA(INDUCES) 12761211; 14523239; 14630912; 14973326; 15003856; 15375192; 18495351; 22933780; 32345612; 33180962 19 0 0 -RCE1 RCE1 iso2 EC 3.4.22.-; Membrane protein, integral; Membrane protein, multi-pass; Protease A0A024R5B6 9986 11q13.2 human K43-ub 40190211 CDLADGLkVVLAPRS Rce1-like protein stabilization; intracellular localization cell growth, inhibited 24134311 1 0 0 -Dab1 DAB1 Adaptor/scaffold P97318 13131 4 C6|4 47.79 cM mouse Y220-p 447630 PETEENIyQVPTSQK molecular association, regulation; intracellular localization neural plasticity; cell differentiation, induced; cell motility, altered; cell adhesion, altered; cytoskeletal reorganization; cell growth, altered Src(INDUCES); CRKL(INDUCES); SOCS1(INDUCES); NCK2(INDUCES); CRK(INDUCES); PIK3R1(INDUCES) 14517291; 15062102; 15091337; 15110774; 19796633; 22586277 12 2 0 alternatively spliced variants -USP20 USP20 DEUBIQUITINASE; EC 3.4.19.12; Protease; Ubiquitin conjugating system; Ubiquitin-specific protease Q9Y2K6 10868 9q34.11 human S333-p 7323248 RMKDRKFsWGQQRTN molecular association, regulation; ubiquitination; enzymatic activity, inhibited ADRB2(DISRUPTS) 25666616 3 13 18 regulates lysosomal trafficking and ubiquitination of ADRB2 -Ccnt1 CCNT1 Cell cycle regulation; Transcription initiation complex Q9QWV9 12455 15|15 F1 mouse K380-ac 25174701 GSQKQASkSVPSAKV molecular association, regulation; enzymatic activity, induced transcription, induced BCDIN3(DISRUPTS); HEXIM1(DISRUPTS) 19387490 3 1 0 enhances CDK9/cyclin T1 transcriptional activity, disrupting HEXIM1 and BCDIN3 association -DYRK1A DYRK1A EC 2.7.12.2; KINASE; Kinase, protein; Protein kinase, CMGC; Protein kinase, dual-specificity (non-receptor) Q13627 1859 21q22.13 human Y145-p 449566 DGYDDDNyDYIVKNG intracellular localization cell cycle regulation; cell differentiation, altered 21878370 1 30 877 -USP33 USP33 DEUBIQUITINASE; EC 3.4.19.12; Protease; Ubiquitin conjugating system; Ubiquitin-specific protease Q8TEY7 23032 1p31.1 human T185-p 1883930900 ELRARGLtGLKNIGN receptor desensitization, induced; ubiquitination 36658650 1 0 0 mediates deubiquitination of arrestin 3 -ESRRA ERR1 DNA-binding; Nuclear receptor; Transcription regulation P11474 2101 11q13.1 human K138-ac 15211510 CQACRFTkCLRVGML zf-C4 molecular association, regulation transcription, inhibited DNA(DISRUPTS) 20484414 1 1 0 -MLH1 MLH1 Cell cycle regulation; DNA repair, damage; Tumor suppressor P40692 4292 3p22.2 human K33-ub 573763746 QRPANAIkEMIENCL HATPase_c_3 molecular association, regulation MSH2(INDUCES); MSH6(INDUCES) 30770470 1 3 0 -NONO NONO Nuclear receptor co-regulator; Nucleolus; RNA splicing; RNA-binding Q15233 4841 Xq13.1 human R251-m2 1881147400 NQQFHKErEQPPRFA carcinogenesis, induced; cell motility, induced; cell growth, induced 33420374 1 1 0 -Bmal1 BMAL1 DNA-binding; Transcription factor Q9WTL8 11865 7 F1|7 59.17 cM mouse S521-p 1878257204 RIRGSSPsSCGSSPL activity, induced transcription, induced 35902736 1 1 0 -PDE4A PDE4A EC 3.1.4.53; Nucleotide Metabolism - purine; Phosphodiesterase P27815 5141 19p13.2 human S145-p 458389 ATSQRREsFLYRSDS enzymatic activity, induced 12023945 4 20 1 -Mavs MAVS Adaptor/scaffold; Membrane protein, integral Q8VCF0 228607 2|2 F1 mouse S330-p 143281204 PSKLPSNsVYAGTVP transcription, induced 28725479 1 1 0 -KLF10 KLF10 C2H2-type zinc finger protein; DNA-binding; Transcription factor Q13118 7071 8q22.3 human S384-p 5263526 GKTYFKSsHLKAHTR molecular association, regulation; intracellular localization DNA(DISRUPTS) 20953893 1 0 1 -DOK1 DOK1 Adaptor/scaffold; Motility/polarity/chemotaxis Q99704 1796 2p13.1 human Y398-p 448369 ARVKEEGyELPYNPA molecular association, regulation; phosphorylation RASA1(INDUCES); NCK1(INDUCES) 11551902 4 15 547 -CFLAR CFLAR Apoptosis O15519 8837 2q33.1 human K195-ub 40245511 AAIQKSLkDPSNNFR protein degradation apoptosis, induced 23559011; 24013390 3 3 0 -HDAC1 HDAC1 DEACETYLASE; Deacetylase; EC 3.5.1.98; Hydrolase; Nuclear receptor co-regulator P56517 373961 chicken S415-p 1872055900 RNSDKRIsCDEEFSD protein stabilization; molecular association, regulation transcription, induced MBD3(DISRUPTS); HDAC2(INDUCES); MTA1(DISRUPTS) 33596269 1 0 0 no effect on homodimerization -FASN FASN ACETYLTRANSFERASE; Acetyltransferase; EC 1.1.1.100; EC 1.3.1.39; EC 2.3.1.38; EC 2.3.1.39; EC 2.3.1.41; EC 2.3.1.85; EC 3.1.2.14; EC 4.2.1.59; Hydrolase; Lipid Metabolism - fatty acid biosynthesis; Lyase; Oxidoreductase P49327 2194 17q25.3 human S1028-p 27930800 LWKDNWVsFMDTMLQ PS-DH transcription, inhibited 23585690 1 2 0 -JAK2 JAK2 EC 2.7.10.2; KINASE; Kinase, protein; Oncoprotein; Protein kinase, TK; Protein kinase, tyrosine (non-receptor) O60674 3717 9p24.1 human Y972-p 470145 EYLGTKRyIHRDLAT PK_Tyr_Ser-Thr activity, induced signaling pathway regulation 23926298 3 1 0 oncogenic kinase Jak2V617F signaling and tumor suppressor (PP2A) activity -OGG1 OGG1 DNA repair, damage; Deoxyribonuclease; EC 4.2.99.18; Lyase O15527 4968 3p25.3 human S231-p 10036106 WLQQLREsSYEEAHK HhH-GPD enzymatic activity, inhibited 19674107 1 0 0 -CAPN2 CAPN2 EC 3.4.22.53; Motility/polarity/chemotaxis; Protease P17655 824 1q41 human S50-p 451162 GTLFQDPsFPAIPSA Peptidase_C2 activity, induced cell motility, altered; cell adhesion, altered 14993287; 26248159 3 1 0 -RAD9A RAD9A Apoptosis; Cell cycle regulation; DNA replication; Deoxyribonuclease; EC 3.1.11.2 Q99638 5883 11q13.2 human S336-p 449816 PGPQPPKsPGPHSEE cell cycle regulation 12734188; 20305300 3 7 10 -Agtr1 AT1 GPCR, family 1; Membrane protein, integral; Membrane protein, multi-pass; Receptor, GPCR P25095 24180 17p12 rat T332-p 467239 KSHSSLStKMSTLSY molecular association, regulation ARRB2(INDUCES) 29146594 3 0 0 BRET -PFKFB2 PFKFB2 Carbohydrate Metabolism - fructose and mannose; EC 2.7.1.105; EC 3.1.3.46; Kinase, other; Motility/polarity/chemotaxis; Phosphatase (non-protein) P26285 287019 cow S484-p 452046 IRRPRNYsVGSRPLQ enzymatic activity, induced 9211863 8 36 101 -TERT TERT iso3 DNA-binding; EC 2.7.7.49; Nucleolus; Transferase O14746-3 7015 5p15.33 human K338-ub 14561004 FLYSSGDkEQLRPSF protein degradation chromatin organization, altered; apoptosis, induced 20453884 1 0 0 -POU5F1 Oct4 DNA-binding; Transcription factor Q01860 5460 6p21.33 human T235-p 15502889 QARKRKRtSIENRVR Homeodomain molecular association, regulation transcription, inhibited DNA(DISRUPTS) 22474382 2 1 1 -ZAP70 ZAP70 EC 2.7.10.2; KINASE; Kinase, protein; Protein kinase, TK; Protein kinase, tyrosine (non-receptor) P43403 7535 2q11.2 human Y493-p 447505 LGADDSYyTARSAGK PK_Tyr_Ser-Thr activity, induced; phosphorylation; enzymatic activity, induced cell differentiation, induced; cell adhesion, altered; transcription, altered; signaling pathway regulation 11514606; 11976341; 15100278; 30992398; 33482200; 7642520; 7781602; 8756661 28 13 427 increases Ca(2+) mobilization and Ras activation -Mta1 MTA1 Motility/polarity/chemotaxis; Nuclear receptor co-regulator; Transcription, coactivator/corepressor Q8K4B0 116870 12|12 F1 mouse K626-ac 460693 RNLLLNGkSYPTKVR molecular association, regulation transcription, induced POLR2A(INDUCES) 17671180 2 0 0 Pax5 transcription -FLRT1 FLRT1 Cell adhesion; Membrane protein, integral; Motility/polarity/chemotaxis Q9NZU1 23769 11q13.1 human Y600-p 14150102 GSRKKDDyMESGTKK TM intracellular localization cell growth, altered 20421966 1 0 0 regulates ERK1/2 activation -PXN PXN Adaptor/scaffold; Cell adhesion; Cytoskeletal; Motility/polarity/chemotaxis P49023 5829 12q24.23 human S178-p 448603 PPLPGALsPLYGVPE Paxillin cell motility, altered; cytoskeletal reorganization; cell adhesion, altered 12853963 9 2 0 -SNAI2 Snail2 Apoptosis; C2H2-type zinc finger protein; Motility/polarity/chemotaxis; Transcription factor O43623 6591 8q11.21 human S158-p 1162843400 CDAQSRKsFSCKYCD activity, induced; protein stabilization; ubiquitination; intracellular localization carcinogenesis, induced; transcription, inhibited 29849120 2 0 0 induces transcriptional repressor activity, inhibits ubiquitination -Kcnb1 Kv2.1 Channel, cation; Channel, ligand-gated; Channel, potassium; Membrane protein, integral; Membrane protein, multi-pass Q03717 16500 2 H3|2 87.22 cM mouse S567-p 473554 LEMGSMPsPVAPLPT Kv2channel activity, induced 24962901 6 6 0 -PAGE4 PAGE4 Cancer Testis Antigen (CTA) O60829 9506 Xp11.23 human T51-p 3913886 PGQEREGtPPIEERK GAGE protein degradation; molecular association, regulation; protein conformation transcription, induced Jun(DISRUPTS) 24559171; 26242913 2 6 7 -Tmbim1 TMBIM1 Membrane protein, integral; Membrane protein, multi-pass Q8BJZ3 69660 1|1 C3 mouse K275-ub 1873041108 QLVLGNRkHTISPED Bax1-I molecular association, regulation Hrs(INDUCES) 28481357 1 1 0 -SPI1 PU.1 DNA-binding; Oncoprotein; Transcription factor P17947 6688 11p11.2 human S41-p 13421401 EYYPYLSsDGESHSD protein degradation; molecular association, regulation; ubiquitination cell differentiation, inhibited FBXW7(INDUCES) 33188146 2 0 0 -GATA2 GATA2 Transcription factor P23769 2624 3q21.3 human K419-ub 1883354002 ECFEELSkCMQEKSS cell growth, inhibited 36251994 1 0 0 -CDH5 CDH5 Cell adhesion; Membrane protein, integral; Motility/polarity/chemotaxis P33151 1003 16q21 human Y731-p 456049 PYDTLHIyGYEGSES CADH_Y-type_LIR molecular association, regulation; receptor internalization, inhibited carcinogenesis, inhibited; cell motility, inhibited; cell adhesion, inhibited; endocytosis, inhibited CTNNB1(DISRUPTS) 16027153; 33604918; 34692535 16 0 1 -FOS Fos DNA-binding; Motility/polarity/chemotaxis; Oncoprotein; Transcription factor P01100 2353 14q24.3 human K265-sm 3289000 SISSMELkTEPFDDF intracellular localization; phosphorylation transcription, inhibited 16055710 2 3 0 intranuclear distribution; phosphorylation at T232 inhibits K265 sumoylation, -BCL3 Bcl-3 Apoptosis; Nuclear receptor co-regulator; Oncoprotein; Transcription regulation P20749 602 19q13.32 human S402-p 3627521 LSASPSSsPSQSPPR protein degradation; molecular association, regulation; ubiquitination transcription, altered; cell growth, altered HDAC6(INDUCES); HDAC3(INDUCES); HDAC1(INDUCES) 15469820 1 0 0 -CTNND1 CTNND1 Actin-binding; Adaptor/scaffold; Cell adhesion; G protein regulator, misc.; Motility/polarity/chemotaxis O60716 1500 11q12.1 human S879-p 450459 LIDRNQKsDKKPDRE molecular association, regulation; intracellular localization cell motility, induced CDH5(DISRUPTS) 22798526; 26504080 7 8 0 melanoma TEM ; increases vascular permeability -H2AC11 H2A.1 DNA-binding P0C0S8 8329 6p22.1 human K15-ub 55610200 GKARAKAkTRSSRAG Histone molecular association, regulation DNA repair, induced 53BP1(INDUCES) 22980979; 29167269; 33188174 8 1 0 -ERBB2 HER2 EC 2.7.10.1; KINASE; Kinase, protein; Membrane protein, integral; Oncoprotein; Protein kinase, TK; Protein kinase, tyrosine (receptor) P04626 2064 17q12 human Y923-p 455127 MTFGAKPyDGIPARE PK_Tyr_Ser-Thr molecular association, regulation SH3BGRL3(INDUCES) 16729043 1 0 1 -Csnk1d CK1D EC 2.7.11.1; EC 2.7.11.26; KINASE; Kinase, protein; Protein kinase, CK1; Protein kinase, Ser/Thr (non-receptor) Q06486 64462 10q32.3 rat S331-p 2192627 RGLPSTAsGRLRGTQ enzymatic activity, inhibited 23861943 1 30 2 -FKBP1A FKBP12 EC 5.2.1.8; Isomerase P62942 2280 20p13 human K53-ub 7251155 PFKFMLGkQEVIRGW FKBP_C protein conformation 31375563 1 7 6 Partially unfolded but not aggregated drives FKBP12 ubiquitylation at the proteasome -Irf4 IRF4 DNA-binding; Oncoprotein; Transcription factor Q64287 16364 13|13 A3.2 mouse S446-p 26335000 YHRSLRHsSIQE___ cell differentiation, induced; transcription, induced DNA(INDUCES) 20697158 2 1 0 production of IL-17 and IL-21 -DOK1 DOK1 Adaptor/scaffold; Motility/polarity/chemotaxis Q99704 1796 2p13.1 human Y296-p 448366 LDSPPALyAEPLDSL molecular association, regulation; intracellular localization RASA1(INDUCES); CD45(INDUCES) 10688886; 19481264 4 14 166 -Klf9 KLF9 C2H2-type zinc finger protein; DNA-binding Q01713 rat S106-p 241497502 VTTESGSsPSHSPEE molecular association, regulation cell motility, inhibited JNK3(INDUCES) 28871032 1 1 0 suppress neurite growth, KLF9 S106/110A mutants enhance optic nerve axon regeneration 2 weeks after optic nerve injury -MCM3 MCM3 DNA replication; EC 3.6.4.12 P25205 4172 6p12.2 human K283-ub 58948908 FSAEDIAkIKKFSKT MCM cell cycle regulation 27621311 1 2 0 KEAP1-MCM3 associates with chromatin in a cell cycle-dependent manner -RAB3IP RAB3IP GEF; GEF, Rab Q96QF0 117177 12q15 human S165-p 472425 LSRLRSPsVLEVREK activity, induced carcinogenesis, induced; exocytosis, induced 36797475 1 5 24 -Epha4 EphA4 EC 2.7.10.1; KINASE; Kinase, protein; Membrane protein, integral; Protein kinase, TK; Protein kinase, tyrosine (receptor) Q03137 13838 1 C4|1 39.55 cM mouse Y596-p 450856 LNQGVRTyVDPFTYE EphA2_TM enzymatic activity, induced cell motility, altered; cytoskeletal reorganization 10848605; 16102535 5 14 75 YY->EE mutation induced receptor clustering that induced growth cone collapse and axonal guidance problems.; in vitro -SMAD2 SMAD2 DNA-binding; Transcription factor Q15796 4087 18q21.1 human K20-ac 478911 KRLLGWKkSAGGSGG intracellular localization cell cycle regulation; cell growth, inhibited; transcription, induced; signaling pathway regulation 17478422; 29187201 2 1 0 -HDAC5 HDAC5 DEACETYLASE; Deacetylase; EC 3.5.1.98; Hydrolase Q9UQL6 10014 17q21.31 human Y642-p 1869973801 PLQPLQVyQAPLSLA intracellular localization 32612176 1 1 0 -PARL PSARL Apoptosis; EC 3.4.21.105; Membrane protein, integral; Membrane protein, multi-pass; Mitochondrial; Protease Q9H300 55486 3q27.1 human S65-p 471330 RKVEPRRsDPGTSGE protein processing 17116872 1 1 0 involved in mitochondrial fragmentation -LBR LBR DNA-binding; Membrane protein, integral; Membrane protein, multi-pass G1N806 turkey S82-p 14575430 RSRSRSRsRSPGRPA molecular association, regulation; protein conformation H3(INDUCES) 22056509 2 4 0 -RIPK2 RIPK2 EC 2.7.10.2; EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, Ser/Thr (non-receptor); Protein kinase, TKL; Protein kinase, tyrosine (non-receptor) O43353 8767 8q21.3 human S176-p 460844 KWRMMSLsQSRSSKS PK_Tyr_Ser-Thr enzymatic activity, induced transcription, inhibited; signaling pathway regulation 16824733; 31350258 4 14 25 inhibits riposome formation -Afdn Afadin Cell adhesion; Motility/polarity/chemotaxis; Oncoprotein Q9QZQ1 17356 17|17 A1 mouse S1795-p 481813 KERQRLFsQGQDVSD phosphorylation signaling pathway regulation 34387373 2 47 300 inhibits AKT and IR phosphorylation thus regulating insulin signaling -DLGAP1 SAPAP1 iso2 Cytoskeletal O14490-2 9229 18p11.31 human S44-p 456939 CRRMRSGsYIKAMGD protein degradation; molecular association, regulation; ubiquitination neural plasticity PSD-95(DISRUPTS) 23143515 2 3 0 -IRS1 IRS1 Adaptor/scaffold; Motility/polarity/chemotaxis P35568 3667 2q36.3 human S1101-p 453434 GCRRRHSsETFSSTP protein degradation; intracellular localization; activity, inhibited 15364919; 26956053; 34253290 13 39 122 disassociation of IRS2 from plasma membrane to cytosol; limits PM-associated PI3K and PIP3 synthesis; inhibition of Pim kinases delays IRS1 degradation -Irs1 IRS1 Adaptor/scaffold; Motility/polarity/chemotaxis P35570 25467 9q34 rat S318-p 451399 MVGGKPGsFRVRASS molecular association, regulation; phosphorylation INSR(DISRUPTS) 15069075 12 17 3 Inhibits tyrosine phosphorylation -MPIG6B G6B Immunoglobulin superfamily; Membrane protein, integral; Receptor, misc. O95866 80739 6p21.33 human Y237-p 454848 PADASTIyAVVV___ G6B molecular association, regulation SH2D1B(NOT_REPORTED); CSK(INDUCES); Src(INDUCES); Syk(INDUCES); SHP-2(INDUCES); SHP-1(INDUCES); Fyn(INDUCES); PLCG2(INDUCES); Arg(NOT_REPORTED); PIK3CA(INDUCES) 23185356; 23322602 2 2 1 -TPX2 TPX2 Cell cycle regulation; Microtubule-binding Q9ULW0 22974 20q11.21 human S310-p 460756 IVKPFNLsQGKKRTF intracellular localization KPNB1(INDUCES) 29276125 1 9 23 accumulation of TPX2 at the prophase centrosome -Styk1 STYK1 EC 2.7.10.2; KINASE; Kinase, protein; Membrane protein, integral; Oncoprotein; Protein kinase, TK; Protein kinase, tyrosine (non-receptor); Protein kinase, tyrosine (receptor) Q6J9G1 243659 6|6 F3 mouse Y334-p 458344 VTLGAPPyPEVPPTS PK_Tyr_Ser-Thr apoptosis, inhibited; cell growth, altered 16322230 1 0 0 mutation of this site promotes cellular apoptosis -KDM4B JMJD2B DEMETHYLASE; Demethylase; EC 1.14.11.-; Oxidoreductase O94953 23030 19p13.3 human S352-p 4957088 TRPTALTsPELSSWS protein stabilization; ubiquitination 28945223 1 0 1 -Slc6a5 SLC6A5 Membrane protein, integral; Membrane protein, multi-pass; Transporter; Transporter, SLC family P58295 171148 1q22 rat K791-ub 31914108 LGLKLPVkDLELGTQ protein degradation; ubiquitination; intracellular localization endocytosis, induced; transcription, altered 23484054; 31628376 2 0 0 LNX2 mediated degradation was slower and seen after 48 hours, PKC regulation of SLC6A5 activity, modulation in the glycine transport activity of SLC6A5 -NFE2L2 NRF2 DNA-binding; Transcription factor Q16236 4780 2q31.2 human K541-ac 7106312 DEKEKLLkEKGENDK bZIP_Maf molecular association, regulation transcription, induced DNA(INDUCES) 19273602 1 1 0 -PKD2L1 PKD2L1 Channel, cation; Membrane protein, integral; Membrane protein, multi-pass; Motility/polarity/chemotaxis Q9P0L9 9033 10q24.31 human S682-p 394791406 EIEKLGRsIVSSPQG activity, induced 29230552 1 0 0 regulates the channel activity -LSM4 LSM4 RNA-binding; Spliceosome Q9Y4Z0 25804 19p13.11 human R125-m2 12190487 GGIPGTGrGQPEKKP molecular association, regulation SMN(INDUCES) 11720283 1 1 2 -Dusp4 DUSP4 EC 3.1.3.16; EC 3.1.3.48; PHOSPHATASE; Protein phosphatase, dual-specificity Q8BFV3 319520 8|8 A4 mouse S390-p 15412243 SNLPYLHsPITTSPS protein stabilization 22430215 2 1 2 -BCKDHB BCKDHB Amino Acid Metabolism - valine, leucine and isoleucine degradation; EC 1.2.4.4; Mitochondrial; Oxidoreductase P21953 594 6q14.1 human S318-p 3336900 DVDTICKsVIKTGRL Transketolase_C enzymatic activity, inhibited E1B-AP5(DISRUPTS) 15576032 1 0 0 -PAH PAH Amino Acid Metabolism - phenylalanine, tyrosine and tryptophan biosynthesis; EC 1.14.16.1; Oxidoreductase P00439 5053 12q23.2 human S16-p 449074 PGLGRKLsDFGQETS molecular association, regulation; protein conformation; enzymatic activity, induced PAH(DISRUPTS) 12185072; 15096628; 20937381 7 7 36 PAH G46S mutant; The conformational change is around the phosphoserine and the catalytic domain (not global). -ARHGAP24 ARHGAP24 GAP; GAP, Rac/Rho; Motility/polarity/chemotaxis Q8N264 83478 4q21.23-q21.3 human S415-p 4757012 HKLDVSRsPPLMVKK activity, induced cytoskeletal reorganization 16862148 1 13 1 membrane blebbing -SLC40A1 SLC40A1 Membrane protein, integral; Membrane protein, multi-pass; Transporter; Transporter, SLC family Q9NP59 30061 2q32.2 human Y303-p 25589101 RDGWVSYyNQPVFLA FPN1; TM receptor internalization, inhibited 22682226 1 0 0 regulates internalization partially but not hepcidin mediated internalization -LTF LTF EC 3.4.21.-; Protease; Secreted; Secreted, signal peptide P02788 4057 3p21.31 human K57-sm 41400403 GPPVSCIkRDSPIQC Transferrin transcription, inhibited 26090800 1 0 0 -FOXM1 FOXM1 iso2 DNA-binding; Transcription factor Q08050-2 2305 12p13.33 human S361-p 471396 PLLPRVSsYLVPIQF protein stabilization transcription, induced 17101782 2 0 0 plays a role in the DNA damage/checkpoint signaling -Nfatc2 NFAT1 DNA-binding; Transcription factor Q60591 18019 2 H3|2 88.91 cM mouse S223-p 447847 PRTSPIMsPRTSLAE protein stabilization; ubiquitination carcinogenesis, induced; cell growth, induced; transcription, induced; transcription, inhibited 11030334; 21628454 2 14 5 inhibits ubiquitination of NFAT1 residues K684 and K897 -KAT7 MYST2 ACETYLTRANSFERASE; Acetyltransferase; EC 2.3.1.48; Nuclear receptor co-regulator; Transcription, coactivator/corepressor O95251 11143 17q21.33 human K155-ub 1877197201 SHDESIAkDMSLKDS protein degradation 32555450 1 1 0 degraded during differentiation -IQGAP1 IQGAP1 GAP; GAP, Ras; Motility/polarity/chemotaxis P46940 8826 15q26.1 human K1465-ub 12287388 KIQTGLKkLTELGTV RasGAP_C activity, induced; molecular association, regulation cell motility, induced CDC42(INDUCES); RAC1(INDUCES) 32094223 1 6 3 K165R, K175R mutant binding compared to WT, ubiquitination of the GRD likely blocks CDC42 binding; 6KR mutant compared to WT -Nlrp3 NLRP3 Inhibitor Q8R4B8 216799 11|11 B1.3 mouse K565-ub 1881229502 VLLENYGkFEKGYLI NLRC4_HD2 activity, induced 33893171 1 0 0 inflammasome activation -Alyref2 Refbp2 DNA-binding; RNA-binding Q9JJW6 56009 1|1 H3 mouse R186-m2 13906407 GGRGSQGrGRGTGRN FoP_duplication molecular association, regulation RNA(DISRUPTS) 20129943 1 1 0 -Pfkfb3 PFKFB3 Carbohydrate Metabolism - fructose and mannose; EC 2.7.1.105; EC 3.1.3.46; KINASE; Kinase, other; Motility/polarity/chemotaxis; PHOSPHATASE; Phosphatase (non-protein) Q9ESY2 170768 2|2 A1 mouse S478-p 9318263 TKKPRINsFEERVAS protein stabilization; ubiquitination; enzymatic activity, induced carcinogenesis, induced; cell motility, induced; cell growth, induced 33931981 2 6 5 promotes glycolysis and Paclitaxel resistance; inhibits ubiquitination -SREBF1 SREBP-1 DNA-binding; Membrane protein, integral; Membrane protein, multi-pass; Transcription factor P36956 6720 17p11.2 human K123-sm 2715401 FSPGPGIkEESVPLS transcription, inhibited 12615929 3 1 0 -Slc10a1 NTCP Membrane protein, integral; Membrane protein, multi-pass; Transporter P26435 24777 6q24 rat S226-p 456205 TPHLLATsSLMPFSG intracellular localization endocytosis, induced 16027164; 24008362 2 0 0 PMA induced internalization of NTCP -FOXO4 FOXO4 DNA-binding; Oncoprotein; Transcription factor P98177 4303 Xq13.1 human K186-ac 459042 MLNPEGGkSGKAPRR Forkhead activity, inhibited transcription, inhibited 12964026 2 0 0 -PLXNB1 PLXNB1 Membrane protein, integral; Motility/polarity/chemotaxis; Receptor, misc. O43157 5364 3p21.31 human Y1732-p 11485312 SVTGKAKyTLNDNRL Plexin_cytopl molecular association, regulation cell motility, altered GRB2(INDUCES); PLCG1(INDUCES); PLCG2(INDUCES) 19805522 1 0 0 -Cfl1 Cofilin-1 Cytoskeletal; Motility/polarity/chemotaxis; Nuclear receptor co-regulator P18760 12631 19|19 A mouse T25-p 7990494 MKVRKSStPEEVKKR Cofilin_ADF activity, induced; protein stabilization; ubiquitination; intracellular localization cytoskeletal reorganization 29878125; 34433058 2 19 15 cofilin-1 phosphorylated on T25 can impair skeletal muscle conrtraction by modulating sarcomeric actin dynamics.; Alters sarcomeric organization inducing cardiac dysfunction -FES Fes EC 2.7.10.2; KINASE; Kinase, protein; Oncoprotein; Protein kinase, TK; Protein kinase, tyrosine (non-receptor); Tumor suppressor P07332 2242 15q26.1 human Y713-p 448353 REEADGVyAASGGLR PK_Tyr_Ser-Thr molecular association, regulation; enzymatic activity, induced cell differentiation, altered; cell growth, altered Fes(INDUCES); Src(NOT_REPORTED) 18046454; 18775312; 7687763; 8334128; 8663427 6 8 114 Y713F mutant was associated with a reduction in levels of Bcr.; mutation of this site reduces autophosphorylation of Y811 -Fxyd1 PLM Cell surface; Channel, misc.; Membrane protein, integral Q9Z239 56188 7|7 B1 mouse S89-p 455220 SSIRRLSsRRR____ intracellular localization 16371442 8 1 49 After stimulation with phorbol ester. -TP73 p73 iso2 DNA-binding; Transcription factor; Tumor suppressor O15350-2 7161 1p36.32 human S289-p 455781 GQVLGRRsFEGRICA P53 activity, induced apoptosis, induced; transcription, altered 12097319 1 0 0 -PLD2 PLD2 EC 3.1.4.4; Lipid Metabolism - ether lipid; Lipid Metabolism - glycerophospholipid; Motility/polarity/chemotaxis; Phospholipase O14939 5338 17p13.2 human Y296-p 10036102 LILKCSSyRQARWWA enzymatic activity, inhibited; enzymatic activity, induced carcinogenesis, inhibited; cell motility, altered 19715678; 20176813; 20647543 3 1 0 -MAP3K11 MLK3 EC 2.7.11.25; KINASE; Kinase, protein; Protein kinase, Ser/Thr (non-receptor); Protein kinase, TKL Q16584 4296 11q13.1 human S705-p 448610 FSLKTPDsPPTPAPL molecular association, regulation BRAF(DISRUPTS) 29084209 2 6 0 oxidative stress-induced invasion of colon cancer cells; promotes MLK3-dependent B-Raf and ERK1/2 activation -CRABP2 CRABP2 Nuclear receptor co-regulator P29373 1382 1q23.1 human K102-sm 25171020 VCEQKLLkGEGPKTS Lipocalin intracellular localization transcription, induced 21998312 1 0 0 translocates from ER to the nucleus -NFE2L2 NRF2 DNA-binding; Transcription factor Q16236 4780 2q31.2 human K110-sm 1877458700 SQVAHIPkSDALYFD intracellular localization carcinogenesis, induced; cell growth, induced; cell motility, inhibited; transcription, induced; cell adhesion, inhibited 31546024; 33299528 2 1 0 increased the antioxidant ability of NRF2 and reduced cellular ROS levels; binding to the GPX2 promoter, recruitment of the coactivator CHD-6, decreases intracellular ROS level in hepatocellular carcinoma (HCC), upregulates PHGDH expression, serine accumulation, resistance to serine starvation, SUMOylation maintains HCC tumorigenesis -BUB1B BUB1B EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, Other; Protein kinase, Ser/Thr (non-receptor); Tumor suppressor O60566 701 15q15.1 human S1043-p 483373 WKVGKLTsPGALLFQ cell cycle regulation 19015317 3 9 3 pS1043 Ab delayed anaphase onset in vivo and in vitro -EEF2K EEF2K EC 2.7.11.20; KINASE; Kinase, protein; Protein kinase, Ser/Thr (non-receptor); Protein kinase, atypical; Translation O00418 29904 16p12.2 human S441-p 23101751 ESENSGDsGYPSEKR protein degradation; molecular association, regulation; ubiquitination translation, induced BTRC(INDUCES); BRD8(INDUCES) 22669845; 25670349 2 3 1 -Cux1 CUTL1 DNA-binding; Membrane protein, integral; Transcription factor P53564 13047 5 G2|5 75.96 cM mouse S1232-p 456479 IDYSQGAsPQPQHQL molecular association, regulation DNA(DISRUPTS) 16081423 2 8 4 -USP8 USP8 DEUBIQUITINASE; EC 3.4.19.12; Protease; Ubiquitin conjugating system; Ubiquitin-specific protease P40818 9101 15q21.2 human Y717-p 484371 PSKLKRSySSPDITQ cell cycle regulation 29472535 1 2 4 trichoplein-mediated inhibition of ciliogenesis -RRN3 TIF1A Nucleolus; Transcription initiation complex Q9NYV6 54700 16p13.11 human S199-p 470003 IIARYVPsTPWFLMP RRN3 molecular association, regulation; activity, inhibited transcription, altered eIF3S6IP(DISRUPTS); TAF4(DISRUPTS) 15004009 2 0 0 -Frs2 FRS2 Adaptor/scaffold Q8C180 327826 10|10 D2 mouse Y349-p 449784 RRPALLNyENLPSLP molecular association, regulation GRB2(INDUCES) 9182757 3 11 89 -EEF2K EEF2K EC 2.7.11.20; KINASE; Kinase, protein; Protein kinase, Ser/Thr (non-receptor); Protein kinase, atypical; Translation O00418 29904 16p12.2 human S500-p 455998 RLHLPRAsAVALEVQ molecular association, regulation; protein conformation; enzymatic activity, induced Calmodulin(INDUCES) 27956550 6 9 2 -PTPN18 BDP1 EC 3.1.3.48; Motility/polarity/chemotaxis; PHOSPHATASE; Protein phosphatase, tyrosine (non-receptor) Q99952 26469 2q21.1 human Y281-p 450259 AVQTEEQyRFLYHTV Y_phosphatase molecular association, regulation TEC(INDUCES) 14679216 1 0 0 -AKT1 Akt1 EC 2.7.11.1; KINASE; Kinase, protein; Oncoprotein; Protein kinase, AGC; Protein kinase, Ser/Thr (non-receptor) Q01314 280991 cow T308-p 447856 KDGATMKtFCGTPEY Pkinase intracellular localization; enzymatic activity, induced 12167717 802 14 18 Translocation to the plasma membrane leads to phosphorylation. -Map1s BPY2-IP1 Apoptosis; Microtubule-binding Q8C052 270058 8|8 B3.3 mouse S786-p 27444827 KAPARPSsASATPRA cytoskeletal reorganization 30266824 1 6 1 inhibit microtubule binding -Rims1 RIMS1 Adaptor/scaffold; Vesicle Q9JIR4 84556 9q13 rat S991-p 481204 PNVPLQRsLDEIHPT neural plasticity 35443170 1 13 1 -Cdh2 CDH2 Cell adhesion; Membrane protein, integral; Motility/polarity/chemotaxis Q9Z1Y3 83501 18p13 rat S869-p 382737701 GSGSTAGsLSSLNSS CADH_Y-type_LIR intracellular localization cytoskeletal reorganization CTNNB1(INDUCES) 29133434 1 0 0 PKD1 colocalizes with N-cadherin at dendritic spines mainly in the postsynaptic compartment, long-term potentiation (LTP) induction and regulates synaptic plasticity -PTK2 FAK EC 2.7.10.2; KINASE; Kinase, protein; Protein kinase, TK; Protein kinase, tyrosine (non-receptor) Q05397 5747 8q24.3 human K152-sm 2793927 NFFYQQVkSDYMLEI FERM_M activity, induced; phosphorylation 34619327 2 0 0 FAK K152 sumoylation is associated with increased FAK Y397 phosphorylation; NFkB activation, ICAM-1, TNF-alpha, and p53 expression endothelial cell activation, inflammation and senescence -HAUS8 HAUS8 Cell cycle regulation Q9BT25 93323 19p13.11 human S20-p 20583301 ATGPTNSsSAKKKDK molecular association, regulation; intracellular localization cell cycle regulation; cytoskeletal reorganization 21705324 2 1 0 disrupts microtubule binding -XBP1 XBP1 DNA-binding; Transcription factor P17861 7494 22q12.1|22q12 human S68-p 21688102 RQRLTHLsPEEKALR bZIP_2 protein degradation; molecular association, regulation; intracellular localization FOXO1A(INDUCES) 23277279 4 7 0 -NGEF ephexin-1 GEF; GEF, Rac/Rho Q8N5V2 25791 2q37.1 human S16-p 34501054 LEKTRRKsASDQWNT molecular association, regulation; phosphorylation carcinogenesis, induced; cell growth, induced; signaling pathway regulation KRas(INDUCES) 34711817 1 2 0 induces C-Raf phosphorylation, induces Ras/MAPK signaling pathway -Arhgef16 ARHGEF16 GEF; GEF, Rac/Rho; Motility/polarity/chemotaxis Q3U5C8 230972 4|4 E2 mouse Y220-p 2424921 FKDDPQLyQEIRERG activity, induced; protein conformation cell motility, induced 33597305 1 4 35 -Ptprb PTPRB EC 3.1.3.48; Membrane protein, integral; Motility/polarity/chemotaxis; PHOSPHATASE; Receptor protein phosphatase, tyrosine B2RU80 19263 10|10 D2 mouse Y1982-p 454267 ENPLFPIyENVNPEY molecular association, regulation cytoskeletal reorganization GRB2(INDUCES); Fyn(INDUCES) 20398064 2 1 39 -OGG1 OGG1 DNA repair, damage; Deoxyribonuclease; EC 4.2.99.18; Lyase O15527 4968 3p25.3 human S232-p 10036104 LQQLRESsYEEAHKA HhH-GPD enzymatic activity, inhibited 19674107 1 0 0 -MCC MCC Cell cycle regulation; Tumor suppressor P23508 4163 5q22.2 human S118-p 3624820 SELRSELsQSQHEVN activity, induced cell cycle regulation 21779472 1 7 2 -CTTN Cortactin Actin-binding; Cytoskeletal; Motility/polarity/chemotaxis Q14247 2017 11q13.3 human S261-p 13879503 EKLQLHEsQKDYKTG HS1_rep molecular association, regulation DYN2(INDUCES) 24753582 1 18 4 formation of matrix, endosomal accumulation of cortactin and its association with DYN2, endosome dynamics during the invasive program of breast tumor cells -DDX60 DDX60 EC 3.6.4.13; Hydrolase Q8IY21 55601 4q32.3 human Y796-p 2183532 SGKTYASyYCMEKVL DEAD molecular association, regulation transcription, inhibited 25981042 1 1 0 reduced ATP binding, inhibited RIG-I-mediated IFN-beta promoter activation -EDC4 EDC4 RNA processing Q6P2E9 23644 16q22.1 human S855-p 56660920 GLQEKHKsLAFHRPP RNA stability, altered 30467221 1 2 0 increase formation of P bodies -Zfpm2 FOG2 C2H2-type zinc finger protein; Nuclear receptor co-regulator Q8CCH7 22762 15 B3.1|15 15.74 cM mouse K324-sm 1873213005 LNSHSGVkMEEFLPP molecular association, regulation transcription, induced GATA4(DISRUPTS) 23226341 1 0 0 desumoylation induces repression -EIF2AK3 PERK EC 2.7.11.1; KINASE; Kinase, protein; Membrane protein, integral; Protein kinase, Other; Protein kinase, Ser/Thr (non-receptor); Translation Q9NZJ5 9451 2p11.2 human S715-p 4270777 HIEIIAPsPQRSRSF phosphorylation transcription, induced 30045994 2 21 1 induces phosphorylation of ELF2a -LYN LYN EC 2.7.10.2; KINASE; Kinase, protein; Oncoprotein; Protein kinase, TK; Protein kinase, tyrosine (non-receptor) P07948 4067 8q12.1 human Y397-p 448695 RVIEDNEyTAREGAK PK_Tyr_Ser-Thr molecular association, regulation; enzymatic activity, induced DNA repair, induced; carcinogenesis, induced; cell motility, induced; cell growth, induced; apoptosis, inhibited; signaling pathway regulation; cell growth, altered STAT3(INDUCES); PAG(INDUCES) 15626731; 18070987; 20564182; 29050963; 29989005; 33512474 34 61 2054 induces cytokine signaling -LRP2 LRP2 Membrane protein, integral; Motility/polarity/chemotaxis; Receptor, misc. P98164 4036 2q31.1 human S4527-p 767902 IFENPMYsARDSAVK receptor internalization, altered; receptor recycling, altered 17555532 1 0 0 -CDKN1B p27Kip1 Cell cycle regulation; Inhibitor; Oncoprotein; Protein kinase, regulatory subunit P46527 1027 12p13.1 human K134-ub 5018202 DTHLVDPkTDPSDSQ protein degradation cell cycle regulation 10318797; 19056892 2 0 0 -MYH10 MYH10 Motility/polarity/chemotaxis; Motor P35580 4628 17p13.1 human S1937-p 2017900 RGGPISFsSSRSGRR molecular association, regulation; intracellular localization; activity, inhibited cytoskeletal reorganization MYH10(INDUCES); ACTA1(INDUCES) 16611744; 25869664; 30655296 3 19 2 -ETS1 Ets-1 DNA-binding; Motility/polarity/chemotaxis; Oncoprotein; Transcription factor P13474 396235 chicken S251-p 449316 GKLGGQDsFESIESY Ets1_N_flank activity, inhibited 7961750 4 13 1 The in vitro interaction of Ets-1 with a high-affinity Ets binding site was assayed with EMSA. -H4C1 H4 DNA-binding P62805 8359 6p22.2 human R3-m2 477687 _____SGrGKGGKGL protein stabilization; molecular association, regulation; acetylation cell growth, induced; chromatin organization, altered; cell differentiation, induced; apoptosis, inhibited; transcription, induced PCAF(INDUCES); PSME4(DISRUPTS) 16103216; 20068219; 32447347; 33989303 10 2 0 -ESPL1 separase EC 3.4.22.49; Protease Q14674 9700 12q13.13 human S1126-p 447673 IAPSTNSsPVLKTKP molecular association, regulation; enzymatic activity, inhibited; protein conformation cell cycle regulation CCNB1(INDUCES); PIN1(INDUCES) 11747808; 16868023; 17974570; 21743463; 25921067 11 10 0 separation of sister chromatids and centriole engagement -ADRB1 ADRB1 GPCR, family 1; Membrane protein, integral; Membrane protein, multi-pass; Receptor, GPCR P08588 153 10q25.3 human S475-p 31010700 RPGFASEsKV_____ receptor recycling, inhibited 24324269 1 0 0 -SASH1 SASH1 Tumor suppressor O94885 23328 6q24.3-q25.1 human S407-p 468680 LSHGRTCsFGGFDLT SLY cytoskeletal reorganization; cell motility, inhibited; signaling pathway regulation 32523092 1 38 12 Hippo/YAP signaling -OPRM1 MOR-1 GPCR, family 1; Membrane protein, integral; Membrane protein, multi-pass; Receptor, GPCR P35372 4988 6q25.2 human S365-p 447783 SNIEQQNsTRIRQNT receptor internalization, altered 18463167 11 6 0 -DMTN dematin Actin-binding; Motility/polarity/chemotaxis; Tumor suppressor Q08495 2039 8p21.3 human S403-p 450255 NELKKKAsLF_____ VHP protein conformation 16472756 5 0 0 controls the actin bundling activity of dematin -SORL1 SORL1 Cell surface; Membrane protein, integral; Receptor, misc. Q92673 6653 11q24.1 human S2206-p 11546400 APMITGFsDDVPMVI molecular association, regulation; protein processing GGA1(INDUCES) 20015111; 21147781 2 1 0 necessary for SORL1 ectodomain shedding -SNCA SNCA Adaptor/scaffold P37840 6622 4q22.1 human T72-gl 10338200 NVGGAVVtGVTAVAQ Synuclein protein stabilization 30651314 1 4 0 inhibits the aggregation of alpha-synuclein but can also alter the structure of a-synuclein aggregates in site specific ways, inhibit a-Synuclein toxicity -TFEB TFEB DNA-binding; Transcription factor P19484 7942 6p21.1 human S138-p 3181625 LSSSAGNsAPNSPMA MITF_TFEB_C_3_N intracellular localization 33753903 1 11 0 -Ulk1 ULK1 Autophagy; EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, Other; Protein kinase, Ser/Thr (non-receptor) NP_001101811 360827 12q16 rat S555-p 3176155 GLGCRLHsAPNLSDF autophagy, induced 37009319 61 26 48 -Snapin SNAPIN Vesicle Q9Z266 20615 3|3 F1 mouse S50-p 448453 HVHAVREsQVELREQ Snapin_Pallidin molecular association, regulation cell growth, inhibited; cell motility, inhibited SNAP-25(INDUCES); DNCLI1(DISRUPTS) 21986494; 26108535 5 0 0 -UBXN2B UBXN2B Adaptor/scaffold; Endoplasmic reticulum Q14CS0 137886 8q12.1 human T59-p 3217944 TVFKSPRtPPQRFYS molecular association, regulation; intracellular localization 20875789 1 9 6 important for Golgi disassembly at mitosis; inhibits p37 binding to Golgi membranes -ARHGEF2 ARHGEF2 GEF; GEF, Rac/Rho; Motility/polarity/chemotaxis Q92974 9181 1q22 human T679-p 449343 PGVELLLtPREPALP activity, induced; molecular association, regulation cytoskeletal reorganization RHOA(INDUCES) 18211802; 19261619 4 10 29 activates RhoA and as a result regulates actin assembly -Dlg4 PSD-95 Adaptor/scaffold P31016 29495 10q24 rat Y533-p 473111 VTQMEVHyARPIIIL Guanylate_kin molecular association, regulation; intracellular localization 20220006 1 0 2 regulates synaptic clustering -AP4E1 AP4E1 Adaptor/scaffold Q9UPM8 23431 15q21.2 human S868-p 22598801 LPLVEKFsYCSLSTP receptor recycling, inhibited 21810154 1 0 0 -NOS3 eNOS Amino Acid Metabolism - arginine and proline; EC 1.14.13.39; Oxidoreductase P29473 287024 cow Y83-p 456466 WELGSITyDTLCAQS enzymatic activity, induced 16123043; 18096817; 23727078 5 2 0 -Smo SMO Cell development/differentiation; GPCR, Fz/Smo family; Membrane protein, integral; Membrane protein, multi-pass; Oncoprotein; Receptor, GPCR P56726 319757 6 A3.3|6 12.36 cM mouse S594-p 1872776114 PGQELSFsMHTVSHD molecular association, regulation transcription, induced PKACA(INDUCES) 33886552 1 1 0 -Akt2 Akt2 EC 2.7.11.1; KINASE; Kinase, protein; Oncoprotein; Protein kinase, AGC; Protein kinase, Ser/Thr (non-receptor) P47197 25233 1q21 rat T309-p 448537 SDGATMKtFCGTPEY Pkinase activity, induced 22846604 16 5 23 Glucose uptake in skeletal muscles -PHLPP1 PHLPP EC 3.1.3.16; PHOSPHATASE; Protein phosphatase, Ser/Thr (non-receptor); Tumor suppressor O60346 23239 18q21.33 human S317-p 25172982 GGWSRRAsPAPSDSS cell cycle regulation 33397691 1 8 0 -P2RY1 P2RY1 GPCR, family 1; Membrane protein, integral; Membrane protein, multi-pass; Receptor, GPCR P47900 5028 3q25.2 human T358-p 10897605 QSKSEDMtLNILPEF receptor internalization, altered 19741005 1 0 0 important for beta-arrestin 2 translocation to the plasma membrane -PAK2 PAK2 EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, STE; Protein kinase, Ser/Thr (non-receptor) Q29502 100009535 rabbit S141-p 448295 TVKQKYLsFTPPEKD enzymatic activity, induced CDC42 iso1(DISRUPTS) 16204230; 18984590 17 84 76 -NPM1 NPM1 Nucleolus; Oncoprotein; RNA-binding; Translation P06748 4869 5q35.1 human K267-ac 461149 SLPKVEAkFINYVKN NPM1-C molecular association, regulation; intracellular localization transcription, altered H3(INDUCES) 19581289 1 10 136 K212/215/229/230/257/267/292R mutant -H3C14 HIST2H3A/C/D DNA-binding Q71DI3 126961 1q21.2 human K79-m1 18465116 REIAQDFkTDLRFQS Histone molecular association, regulation L3MBTL iso4(INDUCES) 23583077 0 5 15 -CRTC1 TORC1 iso2 Transcription factor Q6UUV9-2 23373 19p13.11 human S155-p 8110001 PYGTMYLsPPADTSW protein degradation transcription, inhibited 29408765 1 3 10 -MAPK14 P38A EC 2.7.11.24; KINASE; Kinase, protein; Protein kinase, CMGC; Protein kinase, Ser/Thr (non-receptor) Q16539 1432 6p21.31 human K165-me 1884812100 VNEDCELkILDFGLA protein stabilization; enzymatic activity, induced 35992062 1 1 0 -TBC1D4 AS160 GAP; GAP, Rab O60343 9882 13q22.2 human S341-p 455922 QPRRRHAsAPSHVQP PID molecular association, regulation 14-3-3 beta(INDUCES); 14-3-3 epsilon(INDUCES) 17617058; 20410134 9 57 335 multiple sites (6P) mutant -PRKDC DNAPK DNA repair, damage; EC 2.7.11.1; KINASE; Kinase, protein; Nucleolus; Protein kinase, Ser/Thr (non-receptor); Protein kinase, atypical P78527 5591 8q11.21 human S2655-p 23099448 QTADGRSsFDWLTGS DNAPKcs_CC5 DNA repair, inhibited 24687855 1 1 1 cell survival inhibited -Rela NFkB-p65 DNA-binding; Nuclear receptor co-regulator; Transcription factor Q04207 19697 19 A|19 4.34 cM mouse K123-ac 458971 LGIQCVKkRDLEQAI RHD_DNA_bind intracellular localization; phosphorylation cell differentiation, induced; transcription, inhibited; transcription, altered; signaling pathway regulation 26391411; 27381458 4 0 0 -Smad1 SMAD1 DNA-binding; Transcription factor P97588 25671 19q11 rat S468-p 448363 HNPISSVs_______ cell growth, induced; signaling pathway regulation 21445358 12 20 59 Src/SMAD1 signaling pathway -Stip1 STI1 Chaperone Q60864 20867 19|19 A mouse T198-p 465576 DEEEEAAtPPPPPPP intracellular localization 14754904 2 2 2 -PDE10A PDE10A iso2 EC 3.1.4.17; EC 3.1.4.35; Nucleotide Metabolism - purine; Phosphodiesterase Q9Y233-2 10846 6q27 human T16-p 478273 ASCFRRLtECFLSPS intracellular localization; palmitoylation 14604994; 20610737 2 0 0 -NSFL1C NSFL1C Vesicle Q9UNZ2 55968 20p13 human S140-p 455619 AVERVTKsPGETSKP intracellular localization cytoskeletal reorganization 12810701 1 32 4 -Hcls1 HS1 Adaptor/scaffold; Motility/polarity/chemotaxis P49710 15163 16|16 B3 mouse Y388-p 451635 EPETEPDyEDVGELD molecular association, regulation; intracellular localization ITK(INDUCES) 15166239; 19917685 8 2 37 -PTPN7 HePTP EC 3.1.3.48; Motility/polarity/chemotaxis; PHOSPHATASE; Protein phosphatase, tyrosine (non-receptor) P35236 5778 1q32.1 human T66-p 448311 EPICSVNtPREVTLH molecular association, regulation; protein conformation ERK2(DISRUPTS); P38A(DISRUPTS) 10206983; 16226275 3 5 52 -RPTOR Raptor Adaptor/scaffold Q8N122 57521 17q25.3 human S606-p 53407301 SAHEKLYsLLSDPIP HEAT molecular association, regulation; phosphorylation carcinogenesis, inhibited; cell growth, inhibited; transcription, inhibited; signaling pathway regulation RHEB(DISRUPTS); DEPTOR(INDUCES) 32015438 1 1 0 inhibits phosphorylation of S6K1, inhibits mTORC1 signaling -Oprk1 KOR-1 GPCR, family 1; Membrane protein, integral; Membrane protein, multi-pass; Receptor, GPCR P34975 29335 5q12 rat Y87-p 3082310 VMFVIIRyTKMKTAT 7tm_1 activity, induced 10995763 1 0 0 potentiation for KIR3 activation -TNNI3 TNNI3 Actin-binding; Motility/polarity/chemotaxis; Motor P19429 7137 19q13.42 human T31-p 6796401 SNYRAYAtEPHAKKK Troponin-I_N molecular association, regulation; protein conformation C16orf82(INDUCES); TNC(INDUCES) 18986304 1 0 0 -SNAI2 Snail2 Apoptosis; C2H2-type zinc finger protein; Motility/polarity/chemotaxis; Transcription factor O43623 6591 8q11.21 human S104-p 25603909 KDHSGSEsPISDEEE protein degradation; ubiquitination cell cycle regulation; transcription, induced; cell motility, inhibited CHIP(INDUCES) 23851495; 24662826 4 3 0 -TXNIP TXNIP Apoptosis; Mitochondrial; Motility/polarity/chemotaxis; Tumor suppressor Q9H3M7 10628 1q21.1 human T349-p 3212307 HRLESPTtPLLDDMD protein degradation; ubiquitination 31320475 1 5 8 -TFEB TFEB DNA-binding; Transcription factor P19484 7942 6p21.1 human K279-ac 1878278900 WNKGTILkASVDYIR molecular association, regulation autophagy, inhibited; transcription, inhibited TFEB(DISRUPTS) DNA(DISRUPTS) 31750630 1 0 0 suppresses TFEB transcriptional activity, knocking down dGcn5 in Drosophila eyes reduced hTau aggregation -EEF2K EEF2K EC 2.7.11.20; KINASE; Kinase, protein; Protein kinase, Ser/Thr (non-receptor); Protein kinase, atypical; Translation O00418 29904 16p12.2 human K603-ub 12106679 KGFDYLLkAAEAGDR ubiquitination 25670349 1 5 14 -PTH1R PTHR GPCR, family 2; Membrane protein, integral; Membrane protein, multi-pass; Receptor, GPCR Q03431 5745 3p21.31 human K388-ub 919371600 IVRVLATkLRETNAG 7tm_2 ubiquitination 29444827 1 1 0 abrogation of phosphorylation at positions T387and T392 dramatically decreased PTHR ubiquitination -Bmal1 BMAL1 iso4 DNA-binding; Transcription factor Q9WTL8-4 11865 7 F1|7 59.17 cM mouse S42-p 25230400 CNRKRKGsATDYQES activity, induced transcription, altered 31150620 4 3 2 transcriptional oscillation, synchronization of circadian clocks in peripheral tissues -NFS1 NFS1 Cofactor and Vitamin Metabolism - thiamine; EC 2.8.1.7; Mitochondrial; Transferase Q9Y697 9054 20q11.22 human S293-p 1876620104 GQERGMRsGTVPTPL Aminotran_5 carcinogenesis, induced; apoptosis, inhibited 35221331 1 0 0 -GATA2 GATA2 Transcription factor P23769 2624 3q21.3 human K424-ub 1883354003 LSKCMQEkSSPFSAA cell growth, inhibited 36251994 1 0 0 -TTK TTK Cancer Testis Antigen (CTA); EC 2.7.12.1; KINASE; Kinase, protein; Protein kinase, Other; Protein kinase, dual-specificity (non-receptor) P33981 7272 6q14.1 human S49-p 1880463704 SADTTDNsGTVNQIM intracellular localization 36395767 1 0 0 -Alyref2 Refbp2 DNA-binding; RNA-binding Q9JJW6 56009 1|1 H3 mouse R37-m1 13906416 RNRPAIArGGRNRPA molecular association, regulation RNA(DISRUPTS) 20129943 1 1 0 -Ep300 p300 ACETYLTRANSFERASE; Acetyltransferase; EC 2.3.1.48; Motility/polarity/chemotaxis; Nuclear receptor co-regulator; Transcription, coactivator/corepressor B2RWS6 328572 15|15 E1 mouse S1733-p 1295500 PGDSRRLsIQRCIQS molecular association, regulation cell differentiation, induced MyoD(INDUCES) 17964260 1 0 0 Muscle differentiation -Myb Myb DNA-binding; Oncoprotein; Transcription factor P06876 17863 10 A3|10 9.75 cM mouse T486-p 1308921 PLKMLPQtPSHAVED Cmyb_C sumoylation; protein degradation apoptosis, inhibited; transcription, induced 18006338; 24257756 2 1 0 inhibits Myb sumoylation; stress-induced degredation -BMAL1 BMAL1 DNA-binding; Transcription factor O00327 406 11p15.3 human K538-ac 1968606 DASSPGGkKILNGGT molecular association, regulation transcription, inhibited; transcription, altered CRY1(INDUCES) 18419267; 28388406 8 0 0 -Smad2 SMAD2 DNA-binding; Transcription factor Q62432 17126 18 E3|18 51.42 cM mouse T324-p 23146436 SNVNRNAtVEMTRRH MH2 activity, inhibited cell differentiation, inhibited 28400474 1 0 1 -CGGBP1 CGGBP1 Transcription regulation Q9UFW8 8545 3p11.1 human S164-p 482269 NENQLLNsQDC____ cell cycle regulation; cell growth, induced; DNA repair, inhibited 24196442 1 8 4 telomere integrity, enhances POT1 binding to DNA -SPHK2 SPHK2 EC 2.7.1.91; Kinase, lipid; Lipid Metabolism - sphingolipid Q9NRA0 56848 19q13.33 human S419-p 486446 AHSPLHRsVSDLPLP intracellular localization 17635916 1 0 0 regulation of nuclear shuttling -FANCM FANCM EC 3.6.4.13; Helicase Q8IYD8 57697 14q21.2 human S1045-p 28117600 LSHSAVNsQQNLELN molecular association, regulation; intracellular localization cell cycle regulation; DNA repair, altered; signaling pathway regulation MCM2(INDUCES) 23698467; 31067464 2 1 0 FANCM is recruited to DNA replication fork. -C5AR1 C5aR GPCR, family 1; Membrane protein, integral; Membrane protein, multi-pass; Receptor, GPCR P21730 728 19q13.32 human S334-p 448819 SVVRESKsFTRSTVD molecular association, regulation; receptor desensitization, altered ARRB1(INDUCES); ARRB2(INDUCES) 10636859; 12464600; 17145764 4 0 2 induces translocation of beta-arrestin to the plasma membrane -MVB12B FAM125B Vesicle Q9H7P6 89853 9q33.3 human Y243-p 15167001 STRTDYEyQHSNLYA DUF2464 protein degradation; ubiquitination 20654576 1 1 2 -HSF4 HSF4 Cell development/differentiation; DNA-binding; Transcription, coactivator/corepressor Q9ULV5 3299 16q22.1 human S298-p 4037600 LLKEEPAsPGGDGEA sumoylation; protein stabilization; molecular association, regulation; activity, inhibited transcription, inhibited DAXX(INDUCES) 16371476; 20620219; 30316871 3 1 0 -Dvl1 DVL1 Inhibitor P51141 13542 4 E2|4 87.61 cM mouse S139-p 470073 DNETGTEsMVSHRRE Dishevelled activity, induced cell differentiation, altered 16965538 1 0 0 contributes to B-catenin-dependent Wnt signaling; mutation of this site inhibits double axis formation in Xenopus embryos -BECN1 beclin 1 Adaptor/scaffold; Autophagy; Membrane protein, peripheral Q14457 8678 17q21.31 human T119-p 6406000 LSRRLKVtGDLFDIM BH3 activity, induced; molecular association, regulation Bcl-2(DISRUPTS); Bcl-xL(DISRUPTS) 19180116; 19395874 4 0 0 -SP3 SP3 C2H2-type zinc finger protein; DNA-binding Q02447 6670 2q31.1 human K551-ac 459093 SPADIRIkEEEPDPE transcription, induced 15554904 3 0 0 -Slc12a5 KCC2 iso2 Membrane protein, integral; Membrane protein, multi-pass; Transporter; Transporter, SLC family Q91V14-2 57138 2|2 H3 mouse T1008-p 4767307 PEVHLTWtKDKSVAE SLC12 activity, inhibited 27025876; 30201606 3 1 0 transport activity decreased -Tbx21 TBX21 DNA-binding; Transcription factor Q9JKD8 57765 11|11 D mouse S52-p 64227002 TDRRAGSsLGTPYSG transcription, induced 28424242 1 1 0 induce IFN-gamma expression -Map2k1 MEK1 EC 2.7.12.2; KINASE; Kinase, protein; Protein kinase, STE; Protein kinase, dual-specificity (non-receptor) P31938 26395 9 C|9 34.55 cM mouse T286-p 448286 VEGDAAEtPPRPRTP Pkinase enzymatic activity, inhibited 11684694 8 6 16 -CEP131 CEP131 Calcium-binding Q9UPN4 22994 17q25.3 human S47-p 3216078 KPIVRSVsVVTGSEQ molecular association, regulation 14-3-3 zeta(INDUCES); 14-3-3 epsilon(INDUCES) 26616734 1 21 8 14-3-3-dependent centriolar satellite remodelling upon cell stress. -ACE2 ACE2 EC 3.4.17.23; Membrane protein, integral; Protease Q9BYF1 59272 Xp22.2 human R671-m2 1883574201 LFGEEDVrVANLKPR Collectrin molecular association, regulation Spike Glycoprotein(INDUCES) 36114164 1 1 0 GSK3326595 inhibits SARS-CoV-2 spike pseudovirus infection host cells; GSK3326595 strongly inhibits ACE2-RBD interaction, also inhibits SARS-CoV-2 Omicron Spike1 protein -Ahrr AHRR Transcription factor Q3U1U7 11624 13|13 C1 mouse K583-sm 6423503 FPARMHLkTEPDYRQ molecular association, regulation transcription, inhibited ANKRA2(INDUCES); HDAC5(INDUCES); HDAC4(INDUCES) 19251700 1 2 0 -PKP1 plakophilin 1 Cell adhesion; Motility/polarity/chemotaxis Q13835 5317 1q32.1 human T189-p 15413424 NRYSFYStCSGQKAI activity, induced; protein stabilization cell motility, induced; cell growth, induced; translation, induced; cell adhesion, inhibited 23444369 1 1 9 -LTC4S LTC4S EC 4.4.1.20; Endoplasmic reticulum; Lipid Metabolism - arachidonic acid; Lyase; Membrane protein, integral; Membrane protein, multi-pass; Nuclear envelope Q16873 4056 5q35.3 human S36-p 40511991 ARRAFRVsPPLTTGP MAPEG enzymatic activity, inhibited; protein conformation 27365393 1 2 0 -SP1 SP1 C2H2-type zinc finger protein; DNA-binding; Transcription factor P08047 6667 12q13.13 human K16-sm 2535901 DEMTAVVkIEKGVGG protein degradation; molecular association, regulation; ubiquitination; intracellular localization DNA repair, induced; transcription, inhibited RPT6(INDUCES); RNF4(INDUCES) 18572193; 35124373 3 2 0 -PQBP1 PQBP1 Transcription, coactivator/corepressor O60828 10084 Xp11.23 human S247-p 3175780 FQQRPYPsPGAVLRA molecular association, regulation transcription, induced cGAS(INDUCES) 34385679 1 14 6 binding to cGAS induces cGAS oligomerization -KCNQ5 Kv7.5 Channel, potassium; Membrane protein, integral; Membrane protein, multi-pass Q9NR82 56479 6q13 human S88-p 4780184 GKQGARMsLLGKPLS activity, induced 30061510 1 2 0 -DUSP16 DUSP16 EC 3.1.3.16; EC 3.1.3.48; PHOSPHATASE; Protein phosphatase, dual-specificity Q9BY84 80824 12p13.2 human Y271-p 1880104204 DMSLDEAyRFVKEKR molecular association, regulation; intracellular localization; phosphorylation; enzymatic activity, induced transcription, inhibited; signaling pathway regulation JNK1(NOT_REPORTED); P38A(INDUCES) 36272649 1 0 0 dephosphorylates p38 MAPK or JNK, regulates MAPK signaling -FYB1 SLAP-130 Adaptor/scaffold O15117 2533 5p13.1 human Y595-p 452094 IEDDQEVyDDVAEQD molecular association, regulation; intracellular localization cell adhesion, induced; cell motility, altered; cytoskeletal reorganization; cell adhesion, altered SLP76(INDUCES); NCK1(INDUCES); NCK2(INDUCES) 10570256; 20661443; 23979596; 24769494; 30305305 6 2 63 involved in T cells activation -ATF1 ATF-1 Transcription factor P18846 466 12q13.12 human S41-p 15725600 SLSESEEsQDSSDSI molecular association, regulation; phosphorylation CBP(DISRUPTS) 20730097 2 0 0 primes for S47/S50/S51 phosphorylation -SET SET Apoptosis; DNA replication; DNA-binding; Inhibitor; Nuclear receptor co-regulator; Oncoprotein; Protein phosphatase, regulatory subunit Q01105 6418 9q34.11 human S7-p 455972 _MAPKRQsPLPPQKK phosphorylation cell cycle regulation; carcinogenesis, induced; cell motility, induced; cell growth, induced; apoptosis, inhibited 31097686 2 39 0 enhances Akt phosphorylation at T308 -Psma5 PSMA5 EC 3.4.25.1; Protease; Proteasome complex Q9Z2U1 26442 3|3 F2.3 mouse K203-ac 31910302 KSSLIILkQVMEEKL Proteasome protein degradation 24037710 0 1 0 -PPP1R12A MYPT1 Motility/polarity/chemotaxis; PHOSPHATASE; Protein phosphatase, regulatory subunit O14974 4659 12q21.2-q21.31 human S601-gl 1868585001 TKITTGSsSAGTQSS molecular association, regulation; phosphorylation cell cycle regulation PLK1(DISRUPTS) 32295844 1 1 0 inhibits CDK1-dependent phosphorylation at MYPT1 S473, regulates mitotic progression and centrosome integrity -SNAI1 Snail1 C2H2-type zinc finger protein; Transcription factor O95863 6615 20q13.13 human S82-p 11493501 ASLRLQEsPRVAELT protein stabilization; intracellular localization carcinogenesis, induced; cell motility, induced 23644467 3 0 0 -SLC29A1 SLC29A1 Membrane protein, integral; Membrane protein, multi-pass; Transporter; Transporter, SLC family Q99808 2030 6p21.1 human S254-p 486282 ETKLDLIsKGEEPRA Nucleoside_tran activity, induced; molecular association, regulation cell growth, induced SLC29A1(DISRUPTS) 17520485 2 10 0 -Rarg RARG iso2 DNA-binding; Nuclear receptor P18911-2 19411 15 F3|15 57.4 cM mouse S66-p 455543 SEEMVPSsPSPPPPP activity, induced; protein degradation transcription, altered 12032135 2 0 0 -MAFB MAFB DNA-binding; Oncoprotein; Transcription factor; Tumor suppressor Q9Y5Q3 9935 20q12 human K32-sm 12004404 DLLKFDVkKEPLGRA molecular association, regulation cell cycle regulation; carcinogenesis, induced; cell growth, induced; transcription, induced DNA(INDUCES) 27829226 2 0 0 -WRAP53 WRAP53 Q9BUR4 55135 17p13.1 human S64-p 482238 PVAGSAVsQELREGD molecular association, regulation DNA repair, induced H2AX(INDUCES) 27715493 1 3 0 -RAD52 RAD52 DNA repair, damage P43351 5893 12p13.33 human K190-ac 971232906 PLEVDLTkAKRQDLE molecular association, regulation; intracellular localization DNA repair, induced RFA2(INDUCES); RPA3(INDUCES); RAD51(INDUCES); RPA1(INDUCES) 29590107 1 1 0 accumulation of RAD52 at DSB sites -NR0B2 NR0B2 Nuclear receptor; Nuclear receptor co-regulator; Transcription, coactivator/corepressor Q15466 8431 1p36.11 human K170-ac 15211509 PKEYACLkGTILFNP Hormone_recep protein stabilization; intracellular localization transcription, inhibited 20516075 1 0 0 -Csnk1d CK1D EC 2.7.11.1; EC 2.7.11.26; KINASE; Kinase, protein; Protein kinase, CK1; Protein kinase, Ser/Thr (non-receptor) Q06486 64462 10q32.3 rat T397-p 3362909 QDTSRMStSQIPGRV enzymatic activity, inhibited 23861943 2 7 1 -SEC23B SEC23B Vesicle Q15437 10483 20p11.23 human S186-p 1394461700 SCEGISKsYVFRGTK Sec23_trunk protein stabilization; intracellular localization; protein conformation autophagy, induced SEC16A(INDUCES); SEC24B(INDUCES); SEC24A(INDUCES); SEC31A(INDUCES); SEC13(INDUCES); FBXW5(DISRUPTS) 30596474 1 0 0 Heterodimerization -PSMD2 PSMD2 Cell cycle regulation; Proteasome complex Q13200 5708 3q27.1 human S361-p 487471 ENNRFGGsGSQVDSA activity, induced; molecular association, regulation cell growth, induced RPT2(INDUCES) 31843888 1 38 3 regulates 26S proteosome activity and function -H3C1 H3 DNA-binding P68431 8350 6p22.2 human K36-m1 465523 APATGGVkKPHRYRP Histone cell cycle regulation; transcription, induced 16732292; 19521516 17 19 47 regulates Cdc45 association at replication origins during S -phase of cell cycle, H3K36me1 increases while H3K36me3 delays association -ME1 ME1 Carbohydrate Metabolism - pyruvate; EC 1.1.1.40; Oxidoreductase P48163 4199 6q14.2 human K337-ac 33350408 KIWLVDSkGLIVKGR Malic_M activity, induced; molecular association, regulation; intracellular localization; phosphorylation carcinogenesis, induced ME1(INDUCES) 31735643 1 3 0 decreases phosphorylation at S336; protein dimerization increased -CGAS cGAS EC 2.7.7.86 Q8N884 115004 6q13 human S435-p 1869388601 KHLDKFSsYHVKTAF Mab-21_C carcinogenesis, altered; transcription, induced 36574362 2 0 0 -CD274 PD-L1 Membrane protein, integral Q9NZQ7 29126 9p24.1 human K281-ub 1883389000 IQDTNSKkQSDTHLE protein degradation; ubiquitination 36376293 1 1 0 HUWE1 and TMUB1 antagonistically affect the degradation of PD-L1 -PRKCH PKCH EC 2.7.11.13; KINASE; Kinase, protein; Protein kinase, AGC; Protein kinase, Ser/Thr (non-receptor) P24723 5583 14q23.1 human S675-p 463347 QDEFRNFsYVSPELQ Pkinase_C protein stabilization; enzymatic activity, induced DNA repair, induced; cell motility, induced; cell growth, induced; apoptosis, inhibited 34593629 2 12 1 -LATS2 LATS2 EC 2.7.11.1; KINASE; Kinase, protein; Nuclear receptor co-regulator; Protein kinase, AGC; Protein kinase, Ser/Thr (non-receptor); Tumor suppressor Q9NRM7 26524 13q12.11 human S872-p 10945601 HQRCLAHsLVGTPNY Pkinase cell growth, induced; transcription, inhibited 29934311 5 3 15 -FCGR2B FCGR2B iso2 Cell surface; Membrane protein, integral; Oncoprotein P31994-2 2213 1q23.3 human Y273-p 448507 GAENTITySLLMHPD molecular association, regulation SHP-2(INDUCES) 27834631 4 2 1 -VIM Vimentin Cytoskeletal; Motility/polarity/chemotaxis P08670 7431 10p13 human S73-p 449025 SAVRLRSsVPGVRLL Filament_head molecular association, regulation; phosphorylation cytoskeletal reorganization Vimentin(DISRUPTS) 11895474; 14762106 14 53 32 increases phosphorylation of S5, S7, S8, S9, S10 -AKAP8 AKAP8 Adaptor/scaffold; Cell cycle regulation; Mitochondrial; RNA-binding O43823 10270 19p13.12 human Y150-p 15407467 HNPYRPSySYDYEFD molecular association, regulation 25770215 1 0 1 Phenylalanine mutants inhibited dissociation from nuclear structures; structural chromatin changes -PRKD1 PRKD1 Autophagy; EC 2.7.11.13; KINASE; Kinase, protein; Motility/polarity/chemotaxis; Protein kinase, CAMK; Protein kinase, Ser/Thr (non-receptor) Q15139 5587 14q12 human S738-p 448589 ARIIGEKsFRRSVVG Pkinase molecular association, regulation; ubiquitination; intracellular localization; enzymatic activity, induced cell cycle regulation; cell differentiation, altered; cell growth, induced; cell motility, altered; signaling pathway regulation; transcription, altered ASK1(INDUCES); IKKB(INDUCES); PKCD(INDUCES); JNK1(INDUCES) 11948398; 15024053; 15226414; 15755722; 16891660; 18337243; 18692497; 21285358; 34010649 58 14 20 inhibits ubiquitination and induces stability of Cyclin B1; PKD-MFF signaling -H3c1 H3 DNA-binding P68433 360198 13|13 A3.1 mouse R128-m1 1458612 PKDIQLArRIRGERA Histone chromatin organization, altered 19434510 0 3 0 regulation of senescence-related epigenetics modification -PML PML Nucleolus; Oncoprotein; SUMO LIGASE; SUMO conjugating system; SUMO ligase; Transcription factor; Tumor suppressor; Ubiquitin conjugating system P29590 5371 15q24.1 human S527-p 451472 PHLDGPPsPRSPVIG DUF3583 molecular association, regulation C/EBP-epsilon(INDUCES) 17989716 2 46 23 -Brsk1 BRSK1 EC 2.7.11.1; EC 2.7.11.26; KINASE; Kinase, protein; Protein kinase, CAMK; Protein kinase, Ser/Thr (non-receptor) B2DD29 499073 1q12 rat T189-p 456027 VGDSLLEtSCGSPHY Pkinase intracellular localization; enzymatic activity, induced 18324781; 22020259; 29698519 8 1 0 activation of Sad kinases in the axon during development; Sad kinases are required for the survival of cortical neurons -CCNH CCNH Cell cycle regulation P51946 902 5q14.3 human S5-p 456230 ___MYHNsSQKRHWT activity, inhibited transcription, altered; cell growth, altered 10993082 1 1 0 -AIMP1 SCYE1 Motility/polarity/chemotaxis; Translation; Translation regulation Q12904 9255 4q24 human S140-p 12440055 KKEKKQQsIAGSADS molecular association, regulation GRP94(DISRUPTS) 20510162 1 10 9 -Nphs1 NPHS1 Cell adhesion; Immunoglobulin superfamily; Membrane protein, integral Q9QZS7 54631 7|7 B1 mouse T1139-p 18507017 QWTGDRDtRSSTVST endocytosis, induced 35451598 2 0 0 -RPTOR Raptor Adaptor/scaffold Q8N122 57521 17q25.3 human S863-p 453732 LTQSAPAsPTNKGVH activity, induced; molecular association, regulation; intracellular localization; protein conformation; enzymatic activity, induced; phosphorylation cell cycle regulation RAG1(DISRUPTS) 19346248; 19864431; 21757713; 21900751; 22493283; 26588989 13 101 6 -APC2 APCL Membrane protein, peripheral O95996 10297 19p13.3 human S1160-p 33370500 QETPLVLsRCSSVSS APC_r protein degradation; molecular association, regulation transcription, inhibited axin 1(INDUCES) 24722208 1 0 0 -CAMK2D CAMK2D iso3 EC 2.7.11.17; KINASE; Kinase, protein; Protein kinase, CAMK; Protein kinase, Ser/Thr (non-receptor) Q13557-3 817 4q26 human S332-p 41591301 DGVKKRKsSSSVQMM intracellular localization; enzymatic activity, inhibited cytoskeletal reorganization 26163515 1 0 0 CaMKIID3, S332A significantly increased BDNF protein expression, nuclear localization, neurite extension, and survival. -Ctnnb1 CTNNB1 Actin-binding; Cell adhesion; Motility/polarity/chemotaxis; Nuclear receptor co-regulator; Oncoprotein; Transcription factor Q02248 12387 9 F4|9 72.19 cM mouse S60-p 1875093002 EEEDVDTsQVLYEWE molecular association, regulation cell cycle regulation ECT2(INDUCES) 34585824 2 0 0 -PRKAG1 AMPKG1 Autophagy; Protein kinase, regulatory subunit P54619 5571 12q13.12 human T284-p 1827354810 LKCYLHEtLETIINR CBS activity, induced; intracellular localization autophagy, induced 31983282 1 0 0 Phosphorylation at S192 and T284 plays important role in lysosomal activation of AMPK through lysosomal localization of the AMPK complex. -IFNAR2 IFNAR2 Membrane protein, integral; Receptor, cytokine P48551 3455 21q22.11 human Y411-p 455199 DPFPEEDySSTEGSG molecular association, regulation transcription, induced; signaling pathway regulation STAT2(DISRUPTS) 34813358 2 1 3 induces STAT phosphorylation and signaling -CHEK1 Chk1 EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, CAMK; Protein kinase, Ser/Thr (non-receptor); Tumor suppressor O14757 1111 11q24.2 human S280-p 447831 AKRPRVTsGGVSESP protein degradation; molecular association, regulation; intracellular localization; enzymatic activity, inhibited; enzymatic activity, induced cell cycle regulation; carcinogenesis, induced; DNA repair, inhibited 15107605; 15710331; 22357623; 23108403 11 27 145 -PTBP1 hnRNP I iso1 RNA splicing; RNA-binding P26599-1 5725 19p13.3 human T138-p 18010516 SNHKELKtDSSPNQA RRM_5 molecular association, regulation carcinogenesis, inhibited; RNA splicing, induced; cell differentiation, induced RNA(INDUCES) 35115536 1 5 0 -HSPA5 GRP78 Chaperone; Heat shock protein; KINASE P11021 3309 9q33.3 human K353-ac 13362602 LEDSDLKkSDIDEIV HSP70 molecular association, regulation; phosphorylation apoptosis, induced; signaling pathway regulation PERK(DISRUPTS) 20371724 1 1 0 induces phosphorylation of elf2a and activation of eIf2a-ATF4-CHOP pathway -SERPINA3 SERPINA3 Secreted; Secreted, signal peptide P01011 12 14q32.13 human K235-ac 464672 QSRFYLSkKKWVMVP Serpin molecular association, regulation DNA(INDUCES) 7782318 1 0 0 -Smurf1 SMURF1 EC 6.3.2.-; EC 6.3.2.19; Ligase; UBIQUITIN LIGASE; Ubiquitin conjugating system; Ubiquitin ligase Q9CUN6 75788 5|5 G2 mouse S148-p 27460454 DRIGGGGsVVDCRGL protein degradation; molecular association, regulation; ubiquitination cell differentiation, inhibited AML3(INDUCES); INSR(INDUCES) 26091038; 27052174 2 4 0 glucose homeostasis; ubiquitination and degradation of AML3 -NUMA1 NuMA-1 Cell cycle regulation; Motility/polarity/chemotaxis Q14980 4926 11q13.4 human Y1774-p 449717 VESLESLyFTPIPAR intracellular localization cell cycle regulation; cytoskeletal reorganization 22252550 1 10 85 spindle orientation -Elavl4 ELAVL4 RNA-binding Q61701 15572 4 C7|4 51.42 cM mouse T149-p 40248600 SGLPKTMtQKELEQL RRM_1 intracellular localization translation, induced 25692578 1 0 0 ELAVL4 transport to dendrites -TCERG1 TCERG1 RNA-binding; Spliceosome; Transcription factor O14776 10915 5q32 human K608-sm 13258710 QFSMSAIkEEQELME transcription, inhibited 20215116 1 1 0 sumoylation negatively regulates TCERG transcriptional activity -STK39 STLK3 EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, STE; Protein kinase, Ser/Thr (non-receptor) Q9UEW8 27347 2q24.3 human T231-p 456505 TRNKVRKtFVGTPCW Pkinase activity, induced; phosphorylation; enzymatic activity, induced 17190791; 18270262; 20442269; 22032326 12 5 51 Double knock in lacks its activity; induces phosphorylation of NKCC1 -DNM2 DYN2 EC 3.6.5.5; Hydrolase; Microtubule-binding; Motility/polarity/chemotaxis; Vesicle P50570 1785 19p13.2 human Y597-p 451200 NTEQRNVyKDLRQIE PH molecular association, regulation; intracellular localization; enzymatic activity, inhibited cell differentiation, inhibited; cytoskeletal reorganization; endocytosis, inhibited DYN2(INDUCES) 33113375 5 1 2 -Cdh1 CDH1 Cell adhesion; Membrane protein, integral; Motility/polarity/chemotaxis; UBIQUITIN LIGASE; Ubiquitin ligase P09803 12550 8 D3|8 53.18 cM mouse S853-p 465566 SLSSLNSsESDQDQD CADH_Y-type_LIR molecular association, regulation cell adhesion, altered CTNNB1(INDUCES) 10671552 1 0 0 -ZAP70 ZAP70 EC 2.7.10.2; KINASE; Kinase, protein; Protein kinase, TK; Protein kinase, tyrosine (non-receptor) P43403 7535 2q11.2 human Y492-p 447504 ALGADDSyYTARSAG PK_Tyr_Ser-Thr enzymatic activity, inhibited transcription, altered 8756661 7 13 422 inhibits Ca(2+) mobilization -ESR1 ER-alpha DNA-binding; Nuclear receptor; Transcription factor P03372 2099 6q25.1-q25.2 human K472-sm 27992518 TLKSLEEkDHIHRVL Hormone_recep transcription, induced; transcription, inhibited 22826433; 31141693 2 1 0 -ZNF622 ZNF622 Transcription factor Q969S3 90441 5p15.1 human T318-p 20765000 KGKSFYStEAVQAHM zf-C2H2_2 phosphorylation apoptosis, induced; transcription, induced; signaling pathway regulation 21771788 1 0 0 increases phosphorylation of ASK1 substrates. Suppress PDK1 signaling -Slc9a1 NHE1 Membrane protein, integral; Membrane protein, multi-pass; Motility/polarity/chemotaxis; Transporter; Transporter, SLC family P26431 24782 5q36 rat S775-p 475073 MIRSKEPsSPGTDDV activity, induced 19542484 6 2 0 -GATA4 GATA4 Motility/polarity/chemotaxis; Transcription factor P43694 2626 8p23.1 human K256-ub 1883526402 GINRPLIkPQRRLSA protein degradation; ubiquitination 35659652 1 1 0 negatively modulated cardiomyocyte hypertrophy -CAVIN1 PTRF Transcription initiation complex Q6NZI2 284119 17q21.2 human K289-ac 1873356104 VPAERREkLKTSRDK PTRF_SDPR molecular association, regulation; intracellular localization HSL(INDUCES) 28559430 1 1 0 induces lipolysis -TTK TTK Cancer Testis Antigen (CTA); EC 2.7.12.1; KINASE; Kinase, protein; Protein kinase, Other; Protein kinase, dual-specificity (non-receptor) P33981 7272 6q14.1 human S80-p 2846503 EKNSVPLsDALLNKL intracellular localization 21778823 3 7 0 -Prkaca PKACA EC 2.7.11.11; KINASE; Kinase, protein; Protein kinase, AGC; Protein kinase, Ser/Thr (non-receptor) P05132 18747 8|8 C2 mouse Y331-p 15230353 DTSNFDDyEEEEIRV enzymatic activity, inhibited; enzymatic activity, induced cell motility, induced; transcription, inhibited 21866565; 23447535 2 4 1 inhibition of the PKA and CREB-stimulated expression of the BCL2 gene -Map2k4 MKK4 EC 2.7.12.2; KINASE; Kinase, protein; Protein kinase, STE; Protein kinase, dual-specificity (non-receptor) P47809 26398 11 B3|11 40.53 cM mouse S78-p 447655 IERLRTHsIESSGKL molecular association, regulation; enzymatic activity, inhibited JNK1(DISRUPTS); MEK1(DISRUPTS) 17568772 8 16 87 -CDC25A CDC25A EC 3.1.3.48; Motility/polarity/chemotaxis; PHOSPHATASE; Protein phosphatase, dual-specificity P30304 993 3p21.31 human K150-ub 964504350 NEAFEFKkPVRPVSR M-inducer_phosp intracellular localization 36539837 1 1 0 -CDK2 CDK2 Cell cycle regulation; EC 2.7.11.22; KINASE; Kinase, protein; Protein kinase, CMGC; Protein kinase, Ser/Thr (non-receptor) P24941 1017 12q13.2 human T160-p 447739 GVPVRTYtHEVVTLW Pkinase activity, induced; protein conformation; enzymatic activity, induced cell cycle regulation; chromatin organization, altered CCNA1(INDUCES); CDKN3(DISRUPTS) 10931829; 12359725; 12475985; 1396589; 14551212; 14597612; 15355984; 15671017; 15824106; 17095507; 18593881; 19838212; 24662826 40 35 237 -PYCARD PYCARD Adaptor/scaffold; Tumor suppressor Q9ULZ3 29108 16p11.2 human Y60-p 1868827202 TDKLVSFyLETYGAE PYRIN activity, induced signaling pathway regulation 31333677 1 0 0 important for NLRP2 inflammasome complex formation and function -PLN PLB Inhibitor; Membrane protein, integral P26678 5350 6q22.31 human T17-p 448115 SAIRRAStIEMPQQA Phospholamban molecular association, regulation; protein conformation SERCA2(DISRUPTS); ATP2A1(DISRUPTS) 11854448; 18708665 75 12 63 -RAC1 RAC1 G protein; G protein, monomeric; G protein, monomeric, Rho; Motility/polarity/chemotaxis P63000 5879 7p22.1 human Y64-p 475227 DTAGQEDyDRLRPLS Ras molecular association, regulation cell adhesion, inhibited PAK1(DISRUPTS); ARHGEF7(DISRUPTS); RhoGDI alpha(INDUCES) 22163037; 34252134 2 1 36 inhibits cell spreading -Sik3 QSK EC 2.7.11.1; KINASE; Kinase, protein; Motility/polarity/chemotaxis; Protein kinase, CAMK; Protein kinase, Ser/Thr (non-receptor) Q6P4S6 70661 9|9 A5.2 mouse S551-p 468543 GPLGRRAsDGGANIQ molecular association, regulation; enzymatic activity, inhibited transcription, altered 14-3-3 beta(INDUCES) 30254177; 35997995; 36477539 7 48 120 -ACADVL ACADVL EC 1.3.8.9; Lipid Metabolism - fatty acid; Mitochondrial; Oxidoreductase P49748 37 17p13.1 human K298-ac 1194905 ITHGPPEkKMGIKAS Acyl-CoA_dh_M molecular association, regulation CRLS1(INDUCES) 25811481 1 2 9 both SIRT3 and SIRT5 KO show reduced afinity for CRLS1 -Tyrobp TYROBP Cell surface; Membrane protein, integral O54885 22177 7 B1|7 17.45 cM mouse Y103-p 451740 QGQRPEVySDLNTQR molecular association, regulation DOK3(INDUCES) 23962980 1 3 19 -BACH2 BACH2 DNA-binding; Transcription factor Q9BYV9 60468 6q15 human K580-sm 2798315 NQVRPQIkCEQSYGT intracellular localization 18201693 2 0 0 mobility of nuclear domains -BAX BAX Apoptosis; Membrane protein, integral; Mitochondrial; Tumor suppressor Q07812 581 19q13.33 human T167-p 465510 GLLSYFGtPTWQTVT activity, induced; intracellular localization; phosphorylation apoptosis, induced 15525785; 16709574 3 0 0 -Pde3a PDE3A EC 3.1.4.17; Membrane protein, integral; Membrane protein, multi-pass; Nucleotide Metabolism - purine; Phosphodiesterase Q9Z0X4 54611 6|6 G2 mouse S654-p 36132073 REPQRKAsACGTYTS enzymatic activity, inhibited 34252457 1 2 0 -PRKCQ PKCT EC 2.7.11.13; KINASE; Kinase, protein; Protein kinase, AGC; Protein kinase, Ser/Thr (non-receptor) Q04759 5588 10p15.1 human Y90-p 448588 SETTVELySLAERCR molecular association, regulation; intracellular localization; enzymatic activity, induced transcription, altered Other(INDUCES) 10652356; 17548359 3 0 0 -ARHGEF2 ARHGEF2 GEF; GEF, Rac/Rho; Motility/polarity/chemotaxis B2DCZ9 pig T653-p 449343 PGVELLLtSREPALP activity, induced; molecular association, regulation RHOA(INDUCES) 19261619 4 10 29 -Pou5f1 Oct4 DNA-binding; Transcription factor P20263 18999 17 B1|17 18.69 cM mouse T343-p 291887109 AFPSVPVtALGSPMH protein stabilization; molecular association, regulation; phosphorylation cell differentiation, inhibited; carcinogenesis, induced; cell motility, induced; signaling pathway regulation SOX2(INDUCES); SOX17(DISRUPTS) 28988986; 31996785 2 0 0 ESC Pluripotency; differentiation to ectoderm; induces AKT/GSK3? phosphorylation and Snail1 stabilization, (AKT/GSK3?/Snail1 signaling) -Pak1 PAK1 EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, STE; Protein kinase, Ser/Thr (non-receptor) O88643 18479 7 E1|7 53.57 cM mouse T109-p 14150103 QWARLLQtSNITKSE PBD enzymatic activity, inhibited 20400510 1 1 0 in vitro -Adam17 TACE EC 3.4.24.86; Membrane protein, integral; Motility/polarity/chemotaxis; Protease Q9Z0F8 11491 12 A1.3|12 8.3 cM mouse Y702-p 28706300 DKKLDKQyESLSLFH activity, induced; molecular association, regulation; intracellular localization FAK(INDUCES) 29361535 3 0 0 cell surface localization, TGFB1 upregulation -EIF4EBP1 4E-BP1 Translation; Translation initiation Q13541 1978 8p11.23 human T37-p 447497 PPGDYSTtPGGTLFS eIF_4EBP molecular association, regulation; activity, inhibited; phosphorylation carcinogenesis, induced; carcinogenesis, inhibited; cell growth, inhibited; signaling pathway regulation; translation, altered; cell growth, induced; apoptosis, inhibited; autophagy, inhibited; translation, induced 4E-BP1(DISRUPTS); mTOR(DISRUPTS); EIF4E(DISRUPTS) 12588975; 15051500; 19036825; 21602434; 21734039; 21750219; 21914810; 22071574; 23542178; 23584478; 24247720; 32094692; 34336098; 34546793; 34673774; 35626002; 35864174; 36652560; 37264081; 9465032 159 44 88 -TERT TERT iso3 DNA-binding; EC 2.7.7.49; Nucleolus; Transferase O14746-3 7015 5p15.33 human S921-p 1105513500 VLRLKCHsLFLDLQV apoptosis, inhibited 29748384 1 0 0 protects telomere damage, and results in delayed senescence and protection from apoptosis -TRPC1 TRPC1 Channel, calcium; Membrane protein, integral; Membrane protein, multi-pass P48995 7220 3q23 human T347-p 35542200 SGYRRKPtCKKIMTV signaling pathway regulation 25139746 1 0 0 inhibits 11,12-EET-induced smooth muscle hyperpolarization and relaxation -KCNQ2 Kv7.2 Channel, potassium; Membrane protein, integral; Membrane protein, multi-pass O43526 3785 20q13.33 human T217-p 457689 RMDRRGGtWKLLGSV Ion_trans; TM activity, induced 16319223 3 1 0 -Cald1 Caldesmon Actin-binding Q62736 25687 4q22 rat S527-p 448466 QSVDKVTsPTKV___ intracellular localization cytoskeletal reorganization 16289153 19 19 0 -APOBEC1 APOBEC1 Cell cycle regulation; EC 3.5.4.-; Hydrolase; RNA processing; RNA-binding P41238 339 12p13.31 human S72-p 450067 NFIKKFTsERDFHPS APOBEC4_like enzymatic activity, inhibited 11463337 1 0 0 -RANBP2 RANBP2 Adaptor/scaffold; EC 5.2.1.8; EC 6.3.2.-; Ligase; Nuclear export; Nucleoporin; SUMO LIGASE; SUMO conjugating system; SUMO ligase P49792 5903 2q13 human S2276-p 452314 FSFKSALsPSKSPAK molecular association, regulation; intracellular localization BICD2(INDUCES) 26051540 1 41 1 targets BicD2 to the NE of RGP cells to induce apical nuclear migration -Slc22a1 SLC22A1 Membrane protein, integral; Membrane protein, multi-pass; Transporter; Transporter, SLC family Q63089 24904 1q11 rat S328-p 455613 LCLEEDAsEKRSPSF Sugar_tr activity, induced 15829703 1 0 0 stimulates ASP+ uptake -Il22ra1 IL22RA1 Membrane protein, integral Q80XZ4 230828 4 D3|4 67.99 cM mouse K449-ub 33373904 PGDLSLQkVTSLGEG protein degradation 24742671 1 0 0 -Lrp6 LRP6 Membrane protein, integral; Receptor, misc. O88572 16974 6 G1|6 65.37 cM mouse S1579-p 23122945 TPRSQYLsAEENYES receptor internalization, induced; molecular association, regulation carcinogenesis, inhibited; signaling pathway regulation DAB2(INDUCES); CLTC(INDUCES) 22491013 1 0 1 Wnt/B-catenin signaling -KMT5A SETD8 Amino Acid Metabolism - lysine degradation; EC 2.1.1.43; METHYLTRANSFERASE; Methyltransferase; Methyltransferase, protein lysine Q9NQR1 387893 12q24.31 human K162-ac 31077504 QKIKDARkGPLVPFP protein stabilization; enzymatic activity, induced cell cycle regulation; chromatin organization, altered 23468428 1 0 0 -EPHA2 EphA2 EC 2.7.10.1; KINASE; Kinase, protein; Membrane protein, integral; Protein kinase, TK; Protein kinase, tyrosine (receptor) P29317 1969 1p36.13 human Y594-p 450860 TYVDPHTyEDPNQAV EphA2_TM molecular association, regulation; enzymatic activity, induced cell differentiation, altered; cell motility, altered VAV2(INDUCES); VAV3(INDUCES) 18387945 3 40 738 -PRKD1 PRKD1 Autophagy; EC 2.7.11.13; KINASE; Kinase, protein; Motility/polarity/chemotaxis; Protein kinase, CAMK; Protein kinase, Ser/Thr (non-receptor) Q15139 5587 14q12 human S223-p 455756 RTSSAELsTSAPDEP molecular association, regulation 14-3-3 beta(INDUCES) 15755722 1 0 0 -Alyref2 Refbp2 DNA-binding; RNA-binding Q9JJW6 56009 1|1 H3 mouse R173-m2 13906405 RGGMTRSrGSGGFGG FoP_duplication molecular association, regulation RNA(DISRUPTS) 20129943 1 1 0 -AR AR DNA-binding; Nuclear receptor; Transcription factor P10275 367 Xq12 human K631-me 31094540 GMTLGARkLKKLGNL protein conformation transcription, induced 21273441 1 0 0 -PDHA1 PDHA1 Amino Acid Metabolism - valine, leucine and isoleucine biosynthesis; Carbohydrate Metabolism - butanoate; Carbohydrate Metabolism - citrate (TCA) cycle; Carbohydrate Metabolism - glycolysis and gluconeogenesis; Carbohydrate Metabolism - pyruvate; EC 1.2.4.1; Mitochondrial; Oxidoreductase P08559 5160 Xp22.12 human S232-p 448257 NRYGMGTsVERAAAS E1_dh protein degradation; ubiquitination; enzymatic activity, inhibited carcinogenesis, induced; cell growth, induced; apoptosis, inhibited 11092882; 22289032; 25404640; 27357730; 27498883; 30697423; 30700909; 30797950; 32560271; 32993545; 34667275; 7782287 45 79 7 -DNAJC5 DNAJC5 Vesicle Q9H3Z4 80331 20q13.33 human S10-p 448129 DQRQRSLsTSGESLY molecular association, regulation exocytosis, induced; apoptosis, inhibited 14-3-3 zeta(INDUCES); 14-3-3 epsilon(INDUCES); 14-3-3 gamma(INDUCES); 14-3-3 eta(INDUCES); HSP70(INDUCES) 18951872; 24956274; 29167402 7 80 344 maintain normal conformation of SNAP25, protect dopaminergic neurons; modulate the rate of regulated exocytosis -RPS6KB1 p70S6K EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, AGC; Protein kinase, Ser/Thr (non-receptor); Translation P23443 6198 17q23.1 human S434-p 448356 SFEPKIRsPRRFIGS enzymatic activity, induced 7545671 28 1 0 -MRE11 MRE11A Cell cycle regulation; DNA repair, damage; DNA-binding; Deoxyribonuclease P49959 4361 11q21 human R580-me 2344816 GRGRRGGrGQNSASR intracellular localization 15970667 1 0 0 localizes in nucleus and associates with nuclear bodies and sites of DNA damage -CAMK2A CAMK2A EC 2.7.11.17; KINASE; Kinase, protein; Protein kinase, CAMK; Protein kinase, Ser/Thr (non-receptor) Q9UQM7 815 5q32 human T286-p 447797 SCMHRQEtVDCLKKF molecular association, regulation; intracellular localization; protein conformation; enzymatic activity, induced neural plasticity; cell motility, induced; cell growth, induced; transcription, induced; signaling pathway regulation; cell growth, altered MAP2(INDUCES); Calmodulin(INDUCES); GIT1(INDUCES); MBP(DISRUPTS); NMDAR2B(INDUCES); neurogranin(DISRUPTS) 15866054; 16140754; 16325579; 16436603; 20060891; 21768120; 23352984; 27605043; 33927400; 34667946; 35568036; 36144710 155 34 72 -MBD1 MBD1 Transcription factor Q9UIS9 4152 18q21.1 human K499-sm 3144812 VVALPQVkQEKADTQ molecular association, regulation transcription, induced SETDB1(DISRUPTS) 17066076 1 2 1 -CD247 CD3Z Membrane protein, integral; Receptor, misc. P20963 919 1q24.2 human Y83-p 449322 NLGRREEyDVLDKRR ITAM carcinogenesis, inhibited; signaling pathway regulation 30131370 3 10 277 -TOP2A TOP2A EC 5.99.1.3; Isomerase P11388 7153 17q21.2 human S1106-p 448761 DEEENEEsDNEKETE DNA_topoisoIV molecular association, regulation; enzymatic activity, induced DNA(INDUCES) 12569090; 19043076 3 43 0 -SET SET Apoptosis; DNA replication; DNA-binding; Inhibitor; Nuclear receptor co-regulator; Oncoprotein; Protein phosphatase, regulatory subunit Q01105 6418 9q34.11 human K68-sm 1877628100 QASEEILkVEQKYNK intracellular localization; phosphorylation 30767764 1 0 0 cytoplasmic retention, promotes tau phosphorylation, inhibits PP2A, cognitive deficits with tau pathology in mice -EIF4EBP1 4E-BP1 Translation; Translation initiation Q13541 1978 8p11.23 human T41-p 449366 YSTTPGGtLFSTTPG eIF_4EBP phosphorylation cell growth, induced; translation, induced EIF4E(DISRUPTS) 23584478; 24247720 2 24 54 T41 and T50 act as priming sites for T37/46; T41A and T50A mutants inhibited tumor growth and showed more cap-binding. -NPM/ALK NPM-ALK KINASE; Kinase, protein; Protein kinase, TK; Protein kinase, tyrosine (receptor) AAA58698 human Y338-p 27275110 FGMARDIyRASYYRK PK_Tyr_Ser-Thr enzymatic activity, induced 19887368 3 2 4 -HIF1A HIF1A Autophagy; DNA-binding; Transcription factor Q16665 3091 14q23.2 human K391-me 95155313 SSLFDKLkKEPDALT protein degradation; molecular association, regulation; acetylation; ubiquitination carcinogenesis, inhibited; transcription, inhibited VHL(INDUCES) 28534506 1 1 0 HIF1A methylation and acetylation increased ubiquitination; inhibits VEGF-induced tumor angiogenesis, induces HIF1A hydroxylation -G6PD G6PD Carbohydrate Metabolism - pentose phosphate pathway; Cell development/differentiation; EC 1.1.1.49; Other Amino Acids Metabolism - glutathione; Oxidoreductase P11413 2539 Xq28 human S40-p 1871700806 IFIIMGAsGDLAKKK G6PD_N protein stabilization; enzymatic activity, induced carcinogenesis, inhibited; apoptosis, induced 33398181 1 1 0 stabilizes HK2 -CTNNB1 CTNNB1 Actin-binding; Cell adhesion; Motility/polarity/chemotaxis; Nuclear receptor co-regulator; Oncoprotein; Transcription factor P35222 1499 3p22.1 human S33-p 447487 QQQSYLDsGIHSGAT protein degradation; protein stabilization; molecular association, regulation; ubiquitination; intracellular localization; activity, inhibited; neddylation cell cycle regulation; carcinogenesis, induced; carcinogenesis, inhibited; apoptosis, induced; cell growth, inhibited; transcription, induced; cell motility, inhibited; signaling pathway regulation; transcription, altered; cell adhesion, altered; cytoskeletal reorganization; transcription, inhibited; cell growth, altered CBLL1(INDUCES); TRAF2(DISRUPTS) 11751573; 12000790; 12027456; 15829978; 17018282; 17306568; 18573912; 19060929; 19061640; 19667122; 20300119; 20419129; 22025562; 22234184; 31911618; 32041324; 32046730; 33651074; 33832512; 34117362; 34290402; 34326276; 34749529; 35064015; 35065073; 35108540; 35320710; 35347116; 36575468; 36941998; 37369481; 37400529 112 3 2 -MAD2L1 MAD2L1 Cell cycle regulation Q13257 4085 4q27 human T187-p 22640014 EVRLRSFtTTIHKVN HORMA intracellular localization 23454898 1 0 1 -Apbb1 Fe65 Adaptor/scaffold; Apoptosis; Transcription regulation Q9QXJ1 11785 7 E3|7 55.9 cM mouse S459-p 13309858 VWGVGRDsGSNRDFA PID molecular association, regulation cell growth, induced; signaling pathway regulation ARF6(INDUCES) 36250347 1 1 0 induces ARF6-Rac1 signaling -HIF3A HIF3A Transcription factor; Tumor suppressor Q9Y2N7 64344 19q13.32 human K467-ub 486275 HRLFTSGkDTEAVET protein degradation 12538644 1 0 0 -CHEK2 Chk2 EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, CAMK; Protein kinase, Ser/Thr (non-receptor); Tumor suppressor O96017 11200 22q12.1 human T68-p 447491 SSLETVStQELYSIP molecular association, regulation; intracellular localization; protein conformation; phosphorylation; enzymatic activity, induced cell cycle regulation; carcinogenesis, induced; carcinogenesis, altered; carcinogenesis, inhibited; cell growth, inhibited; apoptosis, induced; signaling pathway regulation; DNA repair, induced; autophagy, induced; cell growth, induced; DNA repair, altered; apoptosis, inhibited; cytoskeletal reorganization; translation, induced PKM(INDUCES); PARP1(INDUCES); PLK1(INDUCES); ULK1(INDUCES); MDC1(INDUCES); ERK2(INDUCES); NBS1(INDUCES); Chk2(INDUCES) 10744722; 11025670; 11085506; 11390408; 11668173; 11901158; 12024051; 12607004; 15048074; 15342622; 15618221; 16150728; 16478990; 16794575; 16940182; 17283158; 17698850; 18948271; 18987440; 20372057; 20406977; 21772273; 21874023; 24844881; 25299772; 27753536; 30001349; 31597105; 33355621; 33851958; 33857133; 33901880; 33961649; 34244606; 34711990; 35513056; 35740063; 35999268; 36273494; 36692427 206 5 0 -Cfl1 Cofilin-1 Cytoskeletal; Motility/polarity/chemotaxis; Nuclear receptor co-regulator P18760 12631 19|19 A mouse S3-p 448444 _____MAsGVAVSDG activity, inhibited neural plasticity; cell motility, induced; cell motility, inhibited; cytoskeletal reorganization 11294912; 19553453; 22172670; 29114038; 34272687; 35325397; 35487245; 36044862; 36434054 97 69 3 -Notch1 Notch 1 Membrane protein, integral; Motility/polarity/chemotaxis; Oncoprotein; Receptor, misc.; Transcription factor Q01705 18128 2 A3|2 18.91 cM mouse K1771-ac 18899505 KVSEASKkKRREPLG protein stabilization; ubiquitination 21499261 1 1 0 -ERBB2 HER2 EC 2.7.10.1; KINASE; Kinase, protein; Membrane protein, integral; Oncoprotein; Protein kinase, TK; Protein kinase, tyrosine (receptor) P04626 2064 17q12 human Y1112-p 448674 DPSPLQRySEDPTVP protein degradation; molecular association, regulation CBL(INDUCES) 10910043 8 2 1 -Tp53 p53 Activator; DNA-binding; Motility/polarity/chemotaxis; Nuclear receptor co-regulator; Transcription factor; Tumor suppressor P02340 22059 11 B3|11 42.83 cM mouse K367-ac 458981 RAHSSYLkTKKGQST activity, induced transcription, induced 33323382 22 3 0 P53K Q/- mice died prematurely due to anemia, loss of hematopoiesis stem cells, Loss of stem cells in the testis, activation in p53 KQ/- mice without robust p53 stabilization,p53-KQ/- mutant leads to effective suppression of tumor development in a pancreatic ductal adenocarcinoma mouse model, mutant proteins extended the life-span of a PDAC mouse model -ARRB2 ARRB2 Adaptor/scaffold P32121 409 17p13.2 human T276-p 50247604 FCKVYTItPLLSDNR Arrestin_C receptor internalization, induced 26324936 2 1 0 -AFAP1 AFAP Adaptor/scaffold Q8N556 60312 4p16.1 human Y451-p 475079 TDPEALHyDYIDVEM molecular association, regulation Src(INDUCES) 9655255 1 0 0 Src Y529F Src mutant -Cttn Cortactin Actin-binding; Cytoskeletal; Motility/polarity/chemotaxis Q60598 13043 7|7 F5 mouse Y466-p 447703 TYTSEPVyETTEAPG molecular association, regulation; intracellular localization carcinogenesis, induced; cell motility, induced; cell motility, inhibited; cytoskeletal reorganization; signaling pathway regulation MTUS2(DISRUPTS); Arg(INDUCES); VAV2(INDUCES); Abl(INDUCES); smMLCK(INDUCES); FAK(DISRUPTS); N-WASP(INDUCES); RAC1(INDUCES) 12408982; 15169891; 17343955; 22078467; 22952866; 24891505; 25825709; 27339664; 27340123; 27451391; 28885660; 34439396 32 3 10 induces Vav2-Rac1 pathway -PLEK pleckstrin Lipid-binding P08567 5341 2p14 human T114-p 478034 QKFARKStRRSIRLP activity, induced 7559487 1 0 129 -Jun Jun Oncoprotein; Transcription factor P17325 24516 5q33 rat S73-p 447943 VGLLKLAsPELERLI Jun activity, induced; protein stabilization transcription, altered; cell growth, altered 12169099; 1749429 84 65 16 -STUB1 CHIP Adaptor/scaffold; EC 6.3.2.-; EC 6.3.2.19; Ligase; UBIQUITIN LIGASE; Ubiquitin conjugating system; Ubiquitin ligase Q9UNE7 10273 16p13.3 human K30-ub 603484814 SPSAQELkEQGNRLF molecular association, regulation 31619515 1 2 0 K30A mutation disrupts interactions with HSPs -SLFN11 SLFN11 Q7Z7L1 91607 17q12 human S753-p 1869008605 QVIRSNPsFNIPTGC activity, inhibited translation, induced 31395656 1 1 0 p24 expression and activity depend on S753 site -Tom1l1 Srcasm Adaptor/scaffold Q923U0 71943 11 D|11 55.47 cM mouse Y440-p 2263200 GDLQPPNyYEVMEFD molecular association, regulation cell growth, altered PIK3R1(INDUCES) 11711534; 17046829 2 1 3 mutation of this site promotes hyperproliferative phenotype -TNK1 TNK1 EC 2.7.10.2; KINASE; Kinase, protein; Protein kinase, TK; Protein kinase, tyrosine (non-receptor) Q13470 8711 17p13.1 human Y277-p 474456 LGGARGRyVMGGPRP PK_Tyr_Ser-Thr enzymatic activity, induced 36334623 2 2 2 -MYH7 MYH7 Motility/polarity/chemotaxis; Motor P12883 4625 14q11.2 human S210-p 27573390 DRSKKDQsPGKGTLE Myosin_head protein conformation 35502901 0 2 0 -Stat5a STAT5A DNA-binding; Motility/polarity/chemotaxis; Oncoprotein; Transcription factor P42230 20850 11 D|11 63.77 cM mouse S127-p 456898 VREANNCsSPAGVLV phosphorylation transcription, induced DNA(INDUCES) 15863494 1 2 0 Phosphorylation of S127 or S128 is required for transcription. Phosphorylation of S127/S128 required for phosphorylation on Y694 and binding of DNA. -GTF2I GTF2I iso2 DNA-binding; Transcription, coactivator/corepressor P78347-2 2969 7q11.23 human S743-p 457075 GVPFRRPsTFGIPRL GTF2I molecular association, regulation transcription, altered SMAD3(INDUCES) 16055503 2 14 266 -SYK Syk EC 2.7.10.2; KINASE; Kinase, protein; Protein kinase, TK; Protein kinase, tyrosine (non-receptor) P43405 6850 9q22.2 human K517-ub 12112713 ISDFGLSkALRADEN PK_Tyr_Ser-Thr molecular association, regulation; intracellular localization; protein conformation; enzymatic activity, induced SHP-1(DISRUPTS) 34362877 1 4 2 TRIM31 attenuated SHP-1 mediated WT SYK dephosphorylation; anti-fungal responses; SYK translocation to the membrane and binding with the C-type lectin receptors (CLRs) -UBE2I UBC9 EC 6.3.2.-; EC 6.3.2.19; Ligase; Nuclear receptor co-regulator; SUMO LIGASE; SUMO conjugating system; SUMO ligase; UBIQUITIN LIGASE; Ubiquitin conjugating system; Ubiquitin ligase P63279 7329 16p13.3 human K18-sm 60338002 QERKAWRkDHPFGFV UQ_con molecular association, regulation; intracellular localization signaling pathway regulation IPO13(INDUCES) 21139563; 27501389 2 1 0 TTR specifically modulates general protein SUMOylation -AR AR DNA-binding; Nuclear receptor; Transcription factor P10275 367 Xq12 human S83-p 448714 QQQQQETsPRQQQQQ Androgen_recep activity, induced; protein stabilization; molecular association, regulation; intracellular localization cell cycle regulation; carcinogenesis, induced; cell motility, induced; transcription, induced; signaling pathway regulation; transcription, altered; cell growth, induced; apoptosis, inhibited CDK5(INDUCES) DNA(INDUCES) 15684382; 21799006; 22275373; 23321516; 27902483; 29423094; 31429764; 33038264; 33932081; 33994848; 36482936 22 1 0 -PRKAG1 AMPKG1 Autophagy; Protein kinase, regulatory subunit P54619 5571 12q13.12 human S192-p 1827354809 KPEFMSKsLEELQIG CBS activity, induced; intracellular localization autophagy, induced 31983282 1 0 0 Phosphorylation at S192 and T284 plays important role in lysosomal activation of AMPK through lysosomal localization of the AMPK complex. -CNN3 calponin 3 Cytoskeletal; Motility/polarity/chemotaxis Q15417 1266 1p21.3 human S293-p 4776192 QGTGTNGsEISDSDY molecular association, regulation cytoskeletal reorganization 20861310 2 5 4 stimulates dissociation of calponin 3 from actin cytoskeleton (F-actin) -Pfkfb3 PFKFB3 Carbohydrate Metabolism - fructose and mannose; EC 2.7.1.105; EC 3.1.3.46; KINASE; Kinase, other; Motility/polarity/chemotaxis; PHOSPHATASE; Phosphatase (non-protein) Q9ESY2 170768 2|2 A1 mouse S467-p 468406 NSVTPLAsPEPTKKP protein stabilization; molecular association, regulation; enzymatic activity, induced carcinogenesis, induced GLUT2(INDUCES) 32580961 2 27 30 -AGO2 AGO2 EC 3.1.26.n2; RNA processing; RNA-binding Q9UKV8 27161 8q24.3 human S824-p 27443092 LVDKEHDsAEGSHTS molecular association, regulation; activity, inhibited transcription, inhibited RNA(DISRUPTS) 28114302 1 7 0 regulates miRNA silencing -Slco1a1 SLCO1A1 Membrane protein, integral; Transporter P46720 50572 4q44 rat S635-p 460720 FPGDIDSsATDHTEM molecular association, regulation; intracellular localization PDZK1(INDUCES) 21183661 1 1 0 plasma membrane distribution of SLCO1A1 requires interaction of its unphosphorylated form with PDZK1 -ZNF282 ZNF282 C2H2-type zinc finger protein Q9UDV7 8427 7q36.1 human K331-sm 31094514 QDLLSRIkQEEHQCV molecular association, regulation carcinogenesis, induced; transcription, induced CALCOCO1(INDUCES); ER-alpha(INDUCES) 22986521 1 0 0 -FOXM1 FOXM1 DNA-binding; Transcription factor Q08050 2305 12p13.33 human K603-ac 57807000 GPFKTPIkETLPISS activity, induced; protein stabilization; molecular association, regulation; phosphorylation carcinogenesis, induced; cell growth, induced; transcription, induced DNA(NOT_REPORTED) 27542221 1 1 0 -ADRA1B ADRA1B GPCR, family 1; Membrane protein, integral; Membrane protein, multi-pass; Receptor, GPCR P18841 101843941 hamster S410-p 451006 DSLDDSGsCMSGSQR receptor desensitization, altered 9353340 1 0 1 -GJA1 GJA1 Channel, misc.; Membrane protein, integral; Membrane protein, multi-pass; Motility/polarity/chemotaxis P17302 2697 6q22.31 human S368-p 447813 QRPSSRAsSRASSRP activity, induced; protein stabilization; molecular association, regulation; intracellular localization; protein conformation; activity, inhibited endocytosis, induced; carcinogenesis, inhibited; apoptosis, induced; cell motility, altered CLTA(INDUCES) 15534005; 17724204; 23828237; 24492000; 24742583; 31365296; 37231448 57 8 1 -FANCD2 FANCD2 DNA repair, damage Q9BXW9 2177 3p25.3 human K561-ub 486248 DMHLVIRkQLSSTVF FancD2 protein stabilization; molecular association, regulation; ubiquitination; intracellular localization cell cycle regulation; DNA repair, induced; transcription, induced; transcription, inhibited; signaling pathway regulation FOXO3A(INDUCES); FANCI(INDUCES); BRCA1(INDUCES); RAD51(INDUCES) DNA(INDUCES) 11239454; 12239151; 12239156; 15454491; 17304220; 20040763; 21355096; 22408259; 22855611; 23965832; 27264184; 27486975 20 12 52 -ERF ERF DNA-binding; Transcription factor P50548 2077 19q13.2 human S161-p 456969 SPTEDPRsPPACSSS intracellular localization cell cycle regulation 10330152 1 6 9 -RUNX1 AML1 DNA-binding; Oncoprotein; Transcription factor Q01196 861 21q22.12 human K188-ub 486731 QKLDDQTkPGSLSFS protein degradation; intracellular localization carcinogenesis, inhibited; cell growth, inhibited; transcription, inhibited 28536267 1 5 6 -IRF5 IRF5 DNA-binding; Transcription factor Q13568 3663 7q32.1 human S437-p 455994 FSGELSWsADSIRLQ activity, induced transcription, induced 12138184; 18836453 2 0 0 -Gsc GSC DNA-binding; Transcription factor Q02591 14836 12 E|12 54.32 cM mouse K238-sm 2887203 KWNKTSSkASPEKRE transcription, inhibited 18336814 1 0 0 SUMO modification inhibition is promoter specific -Cspg4 NG2 Cell adhesion; Membrane protein, integral Q00657 81651 8q24 rat T2256-p 454952 YLRKRNKtGKHDVQV intracellular localization cell motility, altered; cell adhesion, altered 15504744; 17591920 2 0 0 -Cd79a Ig-alpha Immunoglobulin superfamily; Membrane protein, integral P11911 12518 7 A3|7 13.49 cM mouse T203-p 21127302 ISRGLQGtYQDVGNL phosphorylation signaling pathway regulation 21841126 1 1 0 modulates T cell independent type II Ag response; phosphorylation at this site inhibits in vivo phosphorylation of tyrosine in Ig alpha -FMNL2 FMNL2 Cytoskeletal Q96PY5 114793 2q23.3 human S1016-p 3209661 MEQQDPKsPSHKSKR intracellular localization cell cycle regulation; cell adhesion, induced; cytoskeletal reorganization 29930204 1 24 0 -OSBP OSBP Lipid-binding P16258 rabbit S387-p 468343 GSNISGAsSDISLDE phosphorylation 11441133 2 33 1 S381 promotes subsequent phosphorylation of serines 384 and 387 -CDC6 CDC6 Cell cycle regulation Q99741 990 17q21.2 human K92-ac 8539502 PPHSHTLkGRRLVFD intracellular localization cell cycle regulation 19343071 1 0 0 -Nfatc2 NFAT1 DNA-binding; Transcription factor Q60591 18019 2 H3|2 88.91 cM mouse S282-p 447852 RSPSPQPsPHVALQD transcription, inhibited 11030334 0 1 0 -Ywhab 14-3-3 beta Adaptor/scaffold P35213 56011 3q42 rat S132-p 3136105 GDYFRYLsEVASGDN 14-3-3 molecular association, regulation RAF1(DISRUPTS); PKCZ(DISRUPTS) 10620507 1 2 0 -Syngap1 SynGAP iso3 GAP; GAP, Ras Q9QUH6-3 192117 20p12 rat S390-p 18710209 KGKEEVAsALVHILQ molecular association, regulation; intracellular localization HRas(INDUCES) 21382555 1 1 1 -PML PML Nucleolus; Oncoprotein; SUMO LIGASE; SUMO conjugating system; SUMO ligase; Transcription factor; Tumor suppressor; Ubiquitin conjugating system P29590 5371 15q24.1 human K487-ac 4659502 SQTQCPRkVIKMESE DUF3583 sumoylation cell cycle regulation; apoptosis, induced 18621739 2 0 1 -Kcnj11 Kir6.2 Channel, potassium; Membrane protein, integral; Membrane protein, multi-pass Q61743 16514 7 B3|7 29.66 cM mouse T180-p 450652 QAHRRAEtLIFSKHA activity, induced 10908656 2 0 0 PKC-mediated activation of ATP-sensitive potassium channels involves phosphorylation of the Kir6.2 subunit at T180. -POLR2A POLR2A EC 2.7.7.48; EC 2.7.7.6; Nucleotide Metabolism - purine; Nucleotide Metabolism - pyrimidine; Transcription initiation complex; Transferase P24928 5430 17p13.1 human T1540-p 1239966000 PSVGSGMtPGAAGFS molecular association, regulation transcription, induced SPT6(INDUCES) 30135578 1 1 0 -KAT7 MYST2 ACETYLTRANSFERASE; Acetyltransferase; EC 2.3.1.48; Nuclear receptor co-regulator; Transcription, coactivator/corepressor O95251 11143 17q21.33 human T88-p 468239 QQQPTPVtPKKYPLR cell growth, induced 23955388 2 42 46 increase in mammosphere formation -DDR2 DDR2 EC 2.7.10.1; KINASE; Kinase, protein; Membrane protein, integral; Protein kinase, TK; Protein kinase, tyrosine (receptor) Q16832 4921 1q23.3 human Y471-p 451276 EQGSNSTyDRIFPLR molecular association, regulation SHC1(INDUCES) 11884411 1 2 12 -Ptpa PPP2R4 EC 5.2.1.8; Motility/polarity/chemotaxis; Protein phosphatase, regulatory subunit P58389 110854 2 B|2 21.71 cM mouse K302-ub 573769714 YKAECLEkFPVIQHF PTPA protein degradation; ubiquitination; methylation cytoskeletal reorganization 31160454 1 3 0 mediating the effects of UBE3A on spine morphology. -TERF2 TRF2 DNA repair, damage; DNA-binding Q15554 7014 16q22.1 human K335-ac 27581522 MTLKAAFkTLSGAQD TERF2_RBM protein stabilization; molecular association, regulation cell cycle regulation; cell growth, altered DNA(INDUCES) 23307557 1 2 0 regulates cell proliferation and cell cycle; binding to telomere; loss of K335 acetylation induces DNA damage foci at telomeres -PML PML Nucleolus; Oncoprotein; SUMO LIGASE; SUMO conjugating system; SUMO ligase; Transcription factor; Tumor suppressor; Ubiquitin conjugating system P29590 5371 15q24.1 human S530-p 451473 DGPPSPRsPVIGSEV DUF3583 molecular association, regulation C/EBP-epsilon(INDUCES) 17989716 2 29 17 -FOXM1 FOXM1 DNA-binding; Transcription factor Q08050 2305 12p13.33 human T600-p 478080 EVGGPFKtPIKETLP molecular association, regulation; protein stabilization cell cycle regulation; transcription, induced CDC25A(INDUCES) 22094256; 23240008; 33657372 4 1 2 -RELA NFkB-p65 DNA-binding; Nuclear receptor co-regulator; Transcription factor Q04206 5970 11q13.1 human K122-ub 25087018 NLGIQCVkKRDLEQA RHD_DNA_bind protein degradation; molecular association, regulation carcinogenesis, inhibited; cell growth, inhibited; cell motility, inhibited; transcription, inhibited DNA(DISRUPTS) 21706061; 34465889 2 2 0 -NEK2 NEK2 EC 2.7.11.1; KINASE; Kinase, protein; Nucleolus; Protein kinase, Other; Protein kinase, Ser/Thr (non-receptor) P51955 4751 1q32.3 human T179-p 12574601 FAKTFVGtPYYMSPE Pkinase enzymatic activity, inhibited 17197699 1 2 0 -Slc12a5 KCC2 Membrane protein, integral; Membrane protein, multi-pass; Transporter; Transporter, SLC family Q91V14 57138 2|2 H3 mouse T929-p 10045603 SAYTYEKtLVMEQRS SLC12 activity, inhibited cell growth, altered 31615901 7 4 0 necessary for neuronal proliferation and /or migration in developing forebrain -NFKB1 NFkB-p105 DNA-binding; Transcription factor P19838 4790 4q24 human S893-p 451564 EVIQAASsPVKTTSQ activity, induced; protein processing 8522173 2 10 6 Mutation of this site retards the proteolytic processing of p105 that generates active NFkB. -LIN52 LIN52 Cell cycle regulation Q52LA3 91750 14q24.3 human S28-p 4758466 FEKLDRAsPDLWPEQ LIN52 protein degradation; molecular association, regulation cell cycle regulation; cell growth, inhibited; transcription, inhibited P130Cas(INDUCES) 21498570; 30206359; 34728711 3 25 2 -PDPK1 PDK1 EC 2.7.11.1; KINASE; Kinase, protein; Nuclear receptor co-regulator; Protein kinase, AGC; Protein kinase, Ser/Thr (non-receptor) O15530 5170 16p13.3 human T513-p 450132 PEAKNFKtFFVHTPN PH_3 molecular association, regulation; intracellular localization; protein conformation; enzymatic activity, induced PDK1(DISRUPTS) Other(DISRUPTS) 20978239; 23745598 5 4 0 lowers affinity for PIP3 binding -FOXM1 FOXM1 iso2 DNA-binding; Transcription factor Q08050-2 2305 12p13.33 human K445-sm 31898501 LLPVQTIkEEEIQPG protein degradation transcription, inhibited 25533473 2 2 0 -Gatad2a GATAD2A Transcription factor Q8CHY6 234366 8|8 B3.3 mouse S96-p 453704 KSEKRPPsPDVIVLS molecular association, regulation HDAC2(INDUCES) 28346453 1 80 33 -Hck Hck EC 2.7.10.2; KINASE; Kinase, protein; Oncoprotein; Protein kinase, TK; Protein kinase, tyrosine (non-receptor) P08103 15162 2 H1|2 75.41 cM mouse Y50-p 448169 ANQKGPVyVPDPTSS enzymatic activity, induced 10934191 1 4 72 -MPZL1 PZR Adaptor/scaffold; Membrane protein, integral O95297 9019 1q24.2 human Y241-p 451272 SHQGPVIyAQLDHSG molecular association, regulation cell adhesion, altered SHP-2(INDUCES) 11751924 1 17 448 -EPHB1 EphB1 EC 2.7.10.1; KINASE; Kinase, protein; Membrane protein, integral; Protein kinase, TK; Protein kinase, tyrosine (receptor) P54762 2047 3q22.2 human Y594-p 449995 GSPGMKIyIDPFTYE EphA2_TM molecular association, regulation; phosphorylation cell motility, altered; cell adhesion, altered NCK1(INDUCES) 10669731; 12223469; 9430661 5 16 117 JNK1 activation; phosphorylation of Grb7; Stimulation of EphB1 and EphB2 induced a complex between Nik/Nck1, Dok1, RasGAP, and an unidentified 145-kDa tyrosine-phosphorylated protein. -Tmcc3 TMCC3 Membrane protein, integral; Membrane protein, multi-pass Q8R310 319880 10|10 C2 mouse S216-p 4033272 LIRNKFGsADNIAHL Tmemb_cc2 carcinogenesis, induced; cell motility, induced 33742122 0 41 0 -CCDC50 CCDC50 Inhibitor Q8IVM0 152137 3q28 human Y279-p 462101 TDGEDADyTHFTNQQ phosphorylation apoptosis, inhibited; cell growth, altered 19059208 1 10 83 ; inhibits NF-kB activity; inhibits phosphorylation of IKKbeta through TNFalpha -IRS1 IRS1 Adaptor/scaffold; Motility/polarity/chemotaxis P35568 3667 2q36.3 human S312-p 447558 TESITATsPASMVGG protein degradation; molecular association, regulation; intracellular localization apoptosis, altered; cell motility, inhibited IKKA(DISRUPTS); IKKB(DISRUPTS) 12351658; 12510059; 16914728; 18794113; 37298039 77 14 0 -STING1 STING Apoptosis; Endoplasmic reticulum; Membrane protein, integral; Membrane protein, multi-pass; Mitochondrial Q86WV6 340061 5q31.2 human K370-ub 964547962 LLISGMEkPLPLRTD protein degradation 35871231 1 1 0 UFL1 reduces STING ubiquitination -TXN TXN Nuclear receptor co-regulator P10599 7295 9q31.3 human T100-p 457590 NKEKLEAtINELV__ Thioredoxin intracellular localization apoptosis, altered 20619274 1 1 0 -CTNNB1 CTNNB1 Actin-binding; Cell adhesion; Motility/polarity/chemotaxis; Nuclear receptor co-regulator; Oncoprotein; Transcription factor P35222 1499 3p22.1 human S715-p 25288326 GYRQDDPsYRSFHSG protein degradation; molecular association, regulation TIF1G(INDUCES) 25639486 1 0 1 TIF1G abolishes tumorigenesis -Asic3 ASIC3 Channel, cation; Membrane protein, integral; Membrane protein, multi-pass; Transporter; Transporter, ion channel O35240 286920 4q11 rat S523-p 12518703 VTKTLSAsHRTCYLV activity, induced 14976185 1 0 0 channel activation -FOCAD FOCAD Membrane protein, integral; Membrane protein, multi-pass Q5VW36 54914 9p21.3 human K583-ub 21177596 GKEVQWEkLIAKAAS DUF3730 protein degradation 36184622 0 8 0 -TSPYL5 TSPYL5 Q86VY4 85453 8q22.1 human T120-p 3245189 SERLAADtVFVGTAG sumoylation; protein stabilization; ubiquitination; intracellular localization carcinogenesis, induced; cell growth, induced; transcription, altered; signaling pathway regulation 34163000 1 1 0 inhibits ubiquitination, rgulates AKT/TSPYL5/PTEN cyclic signaling -LHX3 LHX3 DNA-binding; Transcription factor Q9UBR4 8022 9q34.3 human S71-p 455295 PLAERCFsRGESVYC LIM activity, induced transcription, induced 15517599 1 0 0 no change in binding to DNA or to certain proteins (NLI, PIT1, or MRG1) -HSPA5 GRP78 Chaperone; Heat shock protein; KINASE P11021 3309 9q33.3 human K585-m3 12261706 DKEKLGGkLSSEDKE HSP70 protein degradation 28912266 3 6 5 METTL21A-dependent tri-methylated GRP78 is degraded, while ERS leads to biosynthesis of non-trimethylated GRP78. -Scn1b SCN1B Channel, sodium; Membrane protein, integral Q00954 29686 1q21 rat Y200-p 455547 AQENASEyLAITSES molecular association, regulation ANK1(DISRUPTS) 11997395 2 0 0 -CERS4 LASS4 DNA-binding; Membrane protein, integral; Membrane protein, multi-pass Q9HA82 79603 19p13.2 human S350-p 7102764 DVEESDSsEEAAAAQ enzymatic activity, induced 26887952 1 7 0 -ACVR1B ALK4 EC 2.7.11.30; KINASE; Kinase, protein; Membrane protein, integral; Protein kinase, Ser/Thr (receptor); Protein kinase, TKL P36896 91 12q13.13 human T206-p 138972400 VQRTVARtIVLQEII cell growth, inhibited; transcription, induced 28650473 1 0 0 -Stk3 MST2 Autophagy; EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, STE; Protein kinase, Ser/Thr (non-receptor) O54748 65189 7q22 rat T180-p 448899 DTMAKRNtVIGTPFW Pkinase enzymatic activity, induced 12554736 15 0 5 -AMFR AMFR EC 6.3.2.-; EC 6.3.2.19; Endoplasmic reticulum; Ligase; Membrane protein, integral; Membrane protein, multi-pass; Motility/polarity/chemotaxis; Receptor, misc.; UBIQUITIN LIGASE; Ubiquitin conjugating system; Ubiquitin ligase Q9UKV5 267 16q13 human S516-p 3148446 SIRPALNsPVERPSS protein degradation; ubiquitination 28528366 1 9 0 -SCYL1 SCYL1 KINASE; Kinase, protein; Protein kinase, Other; Protein kinase, Ser/Thr (non-receptor) Q96KG9 57410 11q13.1 human S754-p 5208514 STQPRPDsWGEDNWE intracellular localization exocytosis, inhibited 35948564 1 17 73 -Cacna1d CACNA1D Channel, calcium; Membrane protein, integral; Membrane protein, multi-pass P27732 29716 16p16 rat S1947-p 1827354811 IGYDSRRsPRRRLLP CAC1F_C activity, inhibited 31983427 1 0 0 Regulates Cav1.3 activity -VHL VHL Tumor suppressor; UBIQUITIN LIGASE; Ubiquitin ligase P40337 7428 3p25.3 human S68-p 469116 PVLRSVNsREPSQVI VHL molecular association, regulation cytoskeletal reorganization HIF2A(DISRUPTS) 16847331 2 2 0 destabilizes microtubules -Fgf23 FGF23 Cytokine; Secreted; Secreted, signal peptide Q9EPC2 64654 6|6 F3 mouse S212-p 36400702 SCSRELPsAEEGGPA protein stabilization exocytosis, induced 25195776 1 1 0 -Spast spastin Cytoskeletal; EC 3.6.4.3; Membrane protein, integral B2RYN7 362700 6q13 rat S210-p 4783443 PLTHASNsLPRSKTV molecular association, regulation; intracellular localization neural plasticity GluR2(INDUCES) 35418834 1 19 2 -ANTXR2 ANTXR2 Membrane protein, integral; Receptor, misc. P58335 118429 4q21.21 human Y463-p 13320000 WALLRRQyDRVSLMR Ant_C ubiquitination 20080640 1 0 0 -FOSL2 FRA2 DNA-binding; Transcription factor P15408 2355 2p23.2 human K104-m1 37038500 LPRPGVIkTIGTTVG methylation cell differentiation, induced; transcription, induced; transcription, inhibited 25547114 1 1 0 -Pik3c3 PIK3C3 Autophagy; Carbohydrate Metabolism - inositol phosphate; EC 2.7.1.137; Kinase, lipid; Motility/polarity/chemotaxis Q6PF93 225326 18|18 B1 mouse K840-sm 31077507 LEPDKTVkKVQDKFR molecular association, regulation cell differentiation, altered; autophagy, induced 30703554 2 0 0 dedifferentiation, pulmonary vascular remodeling and pulmonary arterial hypertension (PAH) -Irs1 IRS1 Adaptor/scaffold; Motility/polarity/chemotaxis P35570 25467 9q34 rat S336-p 455324 GTMSRPAsVDGSPVS phosphorylation 15574412 3 6 9 primes S332 for phosphorylation by GSK3B; decreases tyrosine phosphorylation of IRS-1 and Akt1 phosphorylation upon insulin stimulation -EIF6 EIF6 Nucleolus; Translation; Translation initiation P56537 3692 20q11.22 human S174-p 17535702 IEDQDELsSLLQVPL eIF-6 intracellular localization 21084295 1 1 0 required for the nuclear export of eIF6 -G6PD G6PD Carbohydrate Metabolism - pentose phosphate pathway; Cell development/differentiation; EC 1.1.1.49; Other Amino Acids Metabolism - glutathione; Oxidoreductase P11413 2539 Xq28 human K432-ac 11320995 GNRYKNVkLPDAYER G6PD_C enzymatic activity, altered 37798264 1 6 5 -Gab2 GAB2 Adaptor/scaffold Q9Z1S8 14389 7|7 E1 mouse S469-p 4825114 QSVYIPMsPGPHHFD molecular association, regulation PIK3R1(DISRUPTS) 28096188 1 4 3 -NKX3-1 NKX3-1 DNA-binding; Transcription factor; Tumor suppressor Q99801 4824 8p21.2 human T89-p 464287 AAPEEAEtLAETEPE protein stabilization 16581776 2 1 0 -TGFBR2 TGFBR2 EC 2.7.11.30; KINASE; Kinase, protein; Membrane protein, integral; Oncoprotein; Protein kinase, Ser/Thr (receptor); Protein kinase, TKL P37173 7048 3p24.1 human Y470-p 34729902 AVGEVKDyEPPFGSK PK_Tyr_Ser-Thr activity, induced; phosphorylation signaling pathway regulation 24983314 1 0 0 regulates cell morphology, induces phosphorylation and activation of SMAD3, expression of E-cadherin, collagen synthesis and renal fibrosis; regulates TGF-beta1-mediated activation of canonical signaling -FOXA2 FOXA2 DNA-binding; Transcription factor Q9Y261 3170 20p11.21 human K274-ac 3649004 AGAAGSGkKAAAGAQ protein stabilization transcription, induced 24875183 1 1 6 -AANAT AA-NAT ACETYLTRANSFERASE; Acetyltransferase; Amino Acid Metabolism - tryptophan; EC 2.3.1.87 Q29495 443531 sheep T31-p 452141 PGRQRRHtLPANEFR molecular association, regulation; enzymatic activity, induced 14-3-3 zeta(INDUCES) 15644438; 18771288 4 0 0 -DBI DBI Lipid-binding Q8WN94 100008823 rabbit T36-p 2833501 YSHYKQAtVGDVNTE ACBP molecular association, regulation GABRA1(INDUCES) 18194441 1 1 0 -ATRIP ATRIP Cell cycle regulation; DNA repair, damage; DNA-binding Q8WXE1 84126 3p21.31 human K32-ac 6217746 GTGHPPSkRARGFSA cell cycle regulation; DNA repair, inhibited DNA(DISRUPTS) 26854234 2 1 3 ATR checkpoint -Nolc1 NOLC1 Nucleolus; RNA-binding; Transcription, coactivator/corepressor P41777 64896 1q54 rat S627-p 455685 KKGEKRAsSPFRRVR activity, induced transcription, altered 12167624 1 22 3 -Lcp2 SLP76 Adaptor/scaffold Q60787 16822 11|11 A4 mouse S376-p 476784 IGFQQSAsLPPYFSQ protein degradation; molecular association, regulation; ubiquitination transcription, inhibited LAT(DISRUPTS); 14-3-3 zeta(INDUCES) 22105350; 22902619 5 1 0 phosphorylation causes a disruption of microclusters and prevents T cell activation -CCNF CCNF Cell cycle regulation P41002 899 16p13.3 human S621-p 288031702 GYEGDQEsEGEKEGD activity, inhibited 29021214 1 1 0 regulation the E3 ligase activity of cyclin F -RNF146 RNF146 EC 6.3.2.-; EC 6.3.2.19; UBIQUITIN LIGASE; Ubiquitin conjugating system; Ubiquitin ligase Q9NTX7 81847 6q22.33 human K20-sm 1883827100 NMLPTNRkANESCSN protein degradation cell growth, induced 37029301 1 0 0 degradation of Axin and upregulation of ?-catenin, progression of HCC cells, abolishing RNF146 SUMOylation inhibits HCC cell tumorigenesis -PKM PKM Carbohydrate Metabolism - glycolysis and gluconeogenesis; Carbohydrate Metabolism - pyruvate; EC 2.7.1.40; KINASE; Kinase, other; Mitochondrial; Nucleotide Metabolism - purine P14618 5315 15q23 human K62-ac 11318760 SRSVETLkEMIKSGM PK molecular association, regulation; intracellular localization cell cycle regulation; cell growth, inhibited; transcription, inhibited CTNNB1(DISRUPTS) 33279948 2 7 1 K63 deacetylation induces nuclear translocation. -PFKFB4 PFKFB4 Carbohydrate Metabolism - fructose and mannose; EC 2.7.1.105; EC 3.1.3.46; Kinase, other; Motility/polarity/chemotaxis; Phosphatase (non-protein) Q16877 5210 3p21.31 human T140-p 1879811800 TTRERRAtIFNFGEQ protein stabilization cell motility, induced; cell growth, induced 36109523 1 0 0 -FHL2 FHL2 Motility/polarity/chemotaxis; Nuclear receptor co-regulator; Transcription, coactivator/corepressor Q14192 2274 2q12.2 human Y236-p 25292373 SGLGGTKyISFEERQ LIM cell cycle regulation; cell growth, inhibited 33932144 1 1 9 -NR4A2 NR4A2 DNA-binding; Nuclear receptor P43354 4929 2q24.1 human K577-sm 2407418 LQRIFYLkLEDLVPP Hormone_recep transcription, inhibited 19345186 2 0 0 -NRAS NRas G protein; G protein, monomeric; G protein, monomeric, Ras; Motility/polarity/chemotaxis; Oncoprotein P01111 4893 1p13.2 human S89-p 1867735502 FAINNSKsFADINLY Ras activity, induced; molecular association, regulation; phosphorylation carcinogenesis, induced; cell growth, induced; apoptosis, inhibited; signaling pathway regulation BRAF(INDUCES); RAF1(INDUCES); PIK3CA(INDUCES) 30712867; 32156748 2 1 0 induces phosphorylation of ERK, MEK, Akt and hence NRas signaling; induces NRas signaling pathway -SCML2 SCML2 Transcription factor Q9UQR0 10389 Xp22.13 human S590-p 3216624 SPLVGDIsPKSSPHE cell cycle regulation 24358021 1 29 5 -PDCL PhLP G protein regulator, misc. Q13371 5082 9q33.2 human S20-p 448825 LQYYYSSsEDEDSDH molecular association, regulation G-gamma 2(INDUCES); CCTA(INDUCES) 15889144; 16717095 4 6 3 PhLP phosphorylation at S18-S20 induces association of G-gamma(2) with a G-beta(1)/PhLP complex. These PhLP phosphorylations are also required for normal G-beta/G-gamma dimer assembly.; facilitates dimerization of subunits beta and gamma of G-protein -IKBKG IKKG Adaptor/scaffold; Protein kinase, regulatory subunit Q9Y6K9 8517 Xq28 human K326-ub 7482002 REKLAEKkELLQEQL CC2-LZ protein degradation signaling pathway regulation 17728323; 32935379 2 2 0 -UVRAG UVRAG Autophagy Q9P2Y5 7405 11q13.5 human Y523-p 4761501 YKTPPPSyNSALAQP molecular association, regulation SMURF1(INDUCES) 30686098 1 0 3 -HJURP HJURP Histone-binding; Nucleolus Q8NCD3 55355 2q37.1 human S486-p 482923 GLETRRLsLPSSKAK molecular association, regulation 14-3-3 gamma(INDUCES) 17256767 1 19 3 -Igf2bp1 IGF2BP1 RNA-binding; Translation Q8CGX0 303477 10q26 rat Y396-p 458348 SVTGAAPyGSFMQAP translation, altered 20631164 6 0 0 -ACSL4 ACSL4 EC 6.2.1.3; Ligase; Lipid Metabolism - fatty acid; Membrane protein, integral O60488 2182 Xq23 human T328-p 1876129100 LAHVLELtAEISCFT AMP-binding molecular association, regulation; enzymatic activity, induced carcinogenesis, inhibited ACSL4(INDUCES) 35027735 1 0 0 -CDC14A CDC14A EC 3.1.3.16; EC 3.1.3.48; Motility/polarity/chemotaxis; PHOSPHATASE; Protein phosphatase, dual-specificity Q9UNH5 8556 1p21.2 human S484-p 31085757 INSRLASsLGNLNAA cell cycle regulation; autophagy, induced 33090408 1 2 0 -Srr SRR Amino Acid Metabolism - glycine, serine and threonine; EC 4.3.1.17; EC 4.3.1.18; EC 5.1.1.18; Isomerase Q76EQ0 rat T227-p 7594900 SKLKGELtPNLHPPE PALP intracellular localization 19380732 2 2 0 regulates membrane-binding of Srr -AHR AHR DNA-binding; Transcription factor P35869 196 7p21.1 human S36-p 451413 EGIKSNPsKRHRDRL HLH intracellular localization carcinogenesis, induced; apoptosis, inhibited; transcription, altered 15063792; 35405096 2 1 0 -MYC Myc DNA-binding; Nucleolus; Oncoprotein; Transcription factor P01106 4609 8q24.21 human K338-sm 40724408 RKDYPAAkRVKLDSV Myc_N protein degradation; ubiquitination transcription, inhibited 25895136 1 2 0 -Pdk1 PDHK1 EC 2.7.11.2; KINASE; Kinase, protein; Mitochondrial; Protein kinase, Ser/Thr (non-receptor); Protein kinase, atypical Q8BFP9 228026 2|2 C3 mouse Y241-p 462384 ARRLCDLyYVNSPEL cell growth, induced 22195962 2 1 2 Y to F mutants show decreased proliferation under hypoxia and increased oxidative phosphorylation. -Adcy2 ADCY2 Adenylyl cyclase; EC 4.6.1.1; Lyase; Membrane protein, integral; Membrane protein, multi-pass; Nucleotide Metabolism - purine; Transporter; Transporter, aquaporin family P26769 81636 1p11 rat T1057-p 451157 QTLGYTCtCRGIINV Guanylate_cyc activity, induced 9366262 2 0 0 -Net1 NET1 GEF; GEF, Rac/Rho; Motility/polarity/chemotaxis; Oncoprotein Q9Z206 56349 13|13 A1 mouse S152-p 455600 PTPTKRRsSALWSEM activity, inhibited cytoskeletal reorganization 15684429 1 0 0 inhibits guanine nucleotide exhange activity toward RhoA, inhibits actin stress fiber formation -Cbl CBL Adaptor/scaffold; EC 6.3.2.-; EC 6.3.2.19; Ligase; Motility/polarity/chemotaxis; Oncoprotein; UBIQUITIN LIGASE; Ubiquitin conjugating system; Ubiquitin ligase P22682 12402 9 A5.1-A5.2|9 24.72 cM mouse Y369-p 449753 TQEQYELyCEMGSTF ubiquitination carcinogenesis, inhibited; signaling pathway regulation 36206490 8 10 81 inhibits FLT3 ubiquitination and degradation and hence FLT3 signaling -Gja1 GJA1 Channel, misc.; Membrane protein, integral; Membrane protein, multi-pass; Motility/polarity/chemotaxis P08050 24392 20q11 rat S373-p 459209 RASSRASsRPRPDDL activity, induced; protein degradation; molecular association, regulation; ubiquitination; intracellular localization ZO1(DISRUPTS); 14-3-3 theta(INDUCES); 14-3-3 zeta(INDUCES) 12417300; 17008717; 18163231; 25988944; 29021339 19 7 0 transport to the plasma membrane -MERTK Mer EC 2.7.10.1; KINASE; Kinase, protein; Membrane protein, integral; Oncoprotein; Protein kinase, TK; Protein kinase, tyrosine (receptor) Q12866 10461 2q13 human Y754-p 449990 KIYSGDYyRQGRIAK PK_Tyr_Ser-Thr enzymatic activity, induced 8702477 1 6 71 -ZAP70 ZAP70 EC 2.7.10.2; KINASE; Kinase, protein; Protein kinase, TK; Protein kinase, tyrosine (non-receptor) P43403 7535 2q11.2 human Y126-p 447589 RDAMVRDyVRQTWKL activity, induced; molecular association, regulation; intracellular localization; enzymatic activity, induced PKCT(INDUCES); CD3G(DISRUPTS) 27869819; 30992398 3 1 50 -NSD2 WHSC1 Amino Acid Metabolism - lysine degradation; EC 2.1.1.43; METHYLTRANSFERASE; Methyltransferase; Methyltransferase, protein lysine; Oncoprotein; Ubiquitin conjugating system O96028 7468 4p16.3 human K292-ub 12246197 EGEGQFEkLCQESAK PWWP protein degradation; ubiquitination cell differentiation, induced 32826945 1 2 17 BRCA1 increased polyubiquitination of WHSC1 during K562 cell cell differentiation -UHRF1 UHRF1 DNA-binding; EC 6.3.2.-; EC 6.3.2.19; Ligase; Transcription factor; UBIQUITIN LIGASE; Ubiquitin conjugating system; Ubiquitin ligase Q96T88 29128 19p13.3 human K644-ac 1883407603 FASPRTGkGKWKRKS cell cycle regulation; cell growth, induced 35951156 1 0 0 -MYO3A MYO3A Actin-binding; EC 2.7.11.1; KINASE; Kinase, protein; Motor; Protein kinase, STE; Protein kinase, Ser/Thr (non-receptor) Q8NEV4 53904 10p12.1 human T188-p 36841901 RRNTSVGtPFWMAPE Pkinase intracellular localization; enzymatic activity, induced 25402663 1 1 0 -Gfpt2 GFAT2 Amino Acid Metabolism - alanine, aspartate and glutamate; Carbohydrate Metabolism - amino sugar and nucleotide sugar; EC 2.6.1.16; Transferase Q9Z2Z9 14584 11 B1.2|11 29.9 cM mouse S202-p 451674 AVATRRGsPLLIGVR GATase_6 enzymatic activity, induced 15133036 1 8 0 -NFKB1 NFkB-p105 DNA-binding; Transcription factor P19838 4790 4q24 human K441-ub 5018601 TMDTESKkDPEGCDK molecular association, regulation; protein processing DNA(INDUCES) 10207090 1 0 0 -FGFR1 FGFR1 EC 2.7.10.1; KINASE; Kinase, protein; Membrane protein, integral; Oncoprotein; Protein kinase, TK; Protein kinase, tyrosine (receptor) P11362 2260 8p11.23 human S789-p 4703530 DTRSSTCsSGEDSVF ubiquitination; phosphorylation endocytosis, induced; signaling pathway regulation 24141780 1 2 0 inhibits tyrosine phosphorylation of FGFR1, regulates FGFR1 signaling -CDC25A CDC25A EC 3.1.3.48; Motility/polarity/chemotaxis; PHOSPHATASE; Protein phosphatase, dual-specificity P30304 993 3p21.31 human S513-p 26342100 RTWAGEKsKREMYSR protein degradation cell cycle regulation 21376736 1 1 0 proteasome mediated degradation -CAV1 caveolin-1 Adaptor/scaffold; Motility/polarity/chemotaxis; Nuclear receptor co-regulator Q03135 857 7q31.2 human K5-ub 22241810 ___MSGGkYVDSEGH molecular association, regulation; intracellular localization UBXN6(INDUCES); VCP(INDUCES) 23335559 1 7 0 CAV1 ubiquitylation and binding to the VCP-UBXD1 complex and sorting into lysosomes -GOT2 GOT2 Amino Acid Metabolism - alanine, aspartate and glutamate; Amino Acid Metabolism - arginine and proline; Amino Acid Metabolism - cysteine and methionine; Amino Acid Metabolism - phenylalanine; Amino Acid Metabolism - phenylalanine, tyrosine and tryptophan biosynthesis; Amino Acid Metabolism - tyrosine; EC 2.6.1.1; EC 2.6.1.7; Mitochondrial; Transferase P00505 2806 16q21 human K404-ac 461127 EFSIYMTkDGRISVA Aminotran_1_2 molecular association, regulation; phosphorylation carcinogenesis, induced; cell growth, induced; apoptosis, inhibited MDH2(INDUCES) 25755250 1 7 141 induces H3 phosphorylation -Samhd1 SAMHD1 EC 3.1.4.- Q60710 56045 2|2 H1 mouse T634-p 468674 DIIAPLItPLKWNNK enzymatic activity, inhibited; protein conformation 27920203 22 61 5 ablates its antiviral activity -Gorasp1 GRASP65 Vesicle O35254 56082 8q32 rat S277-p 455582 EQLPGPGsPGHGTAD activity, induced; acetylation; molecular association, regulation; intracellular localization cell cycle regulation; cytoskeletal reorganization; signaling pathway regulation 15834132; 18762583; 23259055; 25948586; 31336000 5 3 0 Regulation of mitotic golgi disassembly and reassembly; Golgi cisternae unstacking and orientation during motility; Golgi fragmentation; inactivation of T220/T224, and eventually S277partial dephosphorylation; inhibits acetylation and microtube stabilization, induce unlinking of Golgi complex and JNK/ERK signaling pathway regulation -GCSAM GCET2 Unknown function Q8N6F7 257144 3q13.2 human Y80-p 449472 QDNVDQTySEELCYT HGAL activity, induced signaling pathway regulation 31362927 1 1 66 regulates B cell receptor signaling -MAX MAX DNA-binding; Transcription factor P61244 4149 14q23.3 human K154-ac 474516 EEPQSRKkLRMEAS_ molecular association, regulation; intracellular localization transcription, induced B-Myc(INDUCES) DNA(DISRUPTS) 17217336 1 1 0 -TTK TTK Cancer Testis Antigen (CTA); EC 2.7.12.1; KINASE; Kinase, protein; Protein kinase, Other; Protein kinase, dual-specificity (non-receptor) P33981 7272 6q14.1 human Y811-p 459314 GTTEEMKyVLGQLVG protein stabilization; enzymatic activity, induced 18680479 1 2 29 -NOTCH1 Notch 1 Membrane protein, integral; Motility/polarity/chemotaxis; Oncoprotein; Receptor, misc.; Transcription factor P46531 4851 9q34.3 human S2516-p 35483202 FLTPSPEsPDQWSSS protein degradation; molecular association, regulation; ubiquitination carcinogenesis, inhibited FBXW7(INDUCES) 25344755 1 1 0 -NCK1 NCK1 Adaptor/scaffold; Motility/polarity/chemotaxis P16333 4690 3q22.3 human K178-ub 40190203 HVGSLSEkLAAVVNN protein degradation cytoskeletal reorganization 24287595 1 0 0 induces stress-fibre formation in synaptopodin-depleted podocytes, regulation of RhoA-mediated actin dynamics -Plk2 PLK2 EC 2.7.11.21; KINASE; Kinase, protein; Protein kinase, Other; Protein kinase, Ser/Thr (non-receptor); Tumor suppressor P53351 20620 13|13 D2.1 mouse T236-p 25790901 PLEHRRRtICGTPNY Pkinase enzymatic activity, induced cytoskeletal reorganization 12651910 2 0 1 The T236E constitutively active mutant, showed arborization and rounding. -Srebf1 SREBP-1 iso4 DNA-binding; Membrane protein, integral; Membrane protein, multi-pass; Transcription factor Q9WTN3-4 20787 11|11 B2 mouse S265-p 7996200 AIEKRYRsSINDKIV HLH molecular association, regulation transcription, altered DNA(DISRUPTS) 19244231 2 1 0 regulates hepatic lipogenesis -Tiam1 TIAM1 GEF; GEF, Rac/Rho; Motility/polarity/chemotaxis; Oncoprotein Q60610 21844 16 C3.3|16 51.5 cM mouse Y384-p 7362700 DRARQGVyENFRREL protein degradation; molecular association, regulation cell motility, altered; cytoskeletal reorganization GRB2(INDUCES); ERK2(INDUCES); ERK1(INDUCES) 19285946 1 2 7 Grb2-Sos1 -FOXC1 FOXC1 Cell cycle regulation; Cell development/differentiation; DNA-binding; Transcription factor Q12948 2296 6p25.3 human S272-p 460580 SSLSSGSsPPGSLPS activity, induced; molecular association, regulation; protein stabilization carcinogenesis, induced; cell motility, induced; transcription, induced DNA(INDUCES) 16492674; 31650548 2 2 0 ubiquitination and protein degradation inhibited. increased MMP10, SOX4 and SOX13 expression levels; activation of ERK1/2 is required for FOXC1 activation and stability -Mst1r Ron EC 2.7.10.1; KINASE; Kinase, protein; Membrane protein, integral; Protein kinase, TK; Protein kinase, tyrosine (receptor) Q62190 19882 9 59.07 cM|9 F1 mouse Y1330-p 456487 ASLLGDHyVQLTAAY enzymatic activity, induced apoptosis, induced; cell growth, altered GRB2(INDUCES); PLCG1(INDUCES); SHC1(INDUCES); PIK3CA(INDUCES) 16103119; 8918464 5 0 0 -TRIM32 TRIM32 EC 6.3.2.-; EC 6.3.2.19; Ligase; UBIQUITIN LIGASE; Ubiquitin conjugating system; Ubiquitin ligase Q13049 22954 9q33.1 human S651-p 27717300 SYHLRRYsTP_____ molecular association, regulation; ubiquitination; intracellular localization; protein conformation cell growth, induced 14-3-3 eta(INDUCES) 23444366 1 1 0 14-3-3 binding prevents both TRIM32 autoubiquitylation and TRIM32 transubiquitylation -SPTBN1 SPTBN1 Cytoskeletal; Motility/polarity/chemotaxis Q01082 6711 2p16.2 human T2159-p 471399 NGATEQRtSSKESSP molecular association, regulation SPTAN1(DISRUPTS) 17088250 1 20 1 increases in PC12 cells during neurite formation -Smad7 SMAD7 DNA-binding; Transcription factor O35253 17131 18|18 E3 mouse K64-ac 458989 RAGCCLGkAVRGAKG protein stabilization; ubiquitination apoptosis, induced 12408818; 17098745 2 2 0 inhibits ubiquitination further inducing protein stabilization; inhibits ubiquitination -UBE2J1 UBE2J1 EC 6.3.2.19; Membrane protein, integral; UBIQUITIN LIGASE; Ubiquitin conjugating system; Ubiquitin ligase Q9Y385 51465 6q15 human S184-p 465537 KELARQIsFKAEVNS protein degradation; enzymatic activity, induced cIAP1(INDUCES) 16720581; 28321712 3 13 52 ER stress cell recovery -Stxbp5 STXBP5 Vesicle Q9WU70 81022 1p13 rat S724-p 459032 GSSSPHNsDDEQKVN molecular association, regulation exocytosis, altered STX1B(DISRUPTS) 16186257 1 6 1 -Ccnd3 CCND3 Activator; Cell cycle regulation; Nuclear receptor co-regulator P30282 12445 17 C|17 23.37 cM mouse T283-p 452160 QGPSQTStPTDVTAI protein degradation; ubiquitination; intracellular localization cell cycle regulation; cell growth, inhibited; cell differentiation, induced; transcription, inhibited 17709384; 26008897 8 4 5 -MAP2K3 MKK3 EC 2.7.12.2; KINASE; Kinase, protein; Protein kinase, STE; Protein kinase, dual-specificity (non-receptor) P46734 5606 17p11.2 human T222-p 448277 LVDSVAKtMDAGCKP Pkinase activity, induced; enzymatic activity, induced cell cycle regulation; transcription, induced 17438131; 8622669; 9162092 6 2 2 -Tjp1 ZO1 Adaptor/scaffold; Motility/polarity/chemotaxis P39447 21872 7 C|7 35.02 cM mouse Y1177-p 450402 YRPEAQPySSTGPKS cell cycle regulation; cell motility, altered 18515860 0 5 36 -STAT3 STAT3 DNA-binding; Motility/polarity/chemotaxis; Nuclear receptor co-regulator; Transcription factor P40763 6774 17q21.2 human Y45-p 464379 IESQDWAyAASKESH STAT_int protein conformation transcription, induced 29531159 1 5 14 regulates dimerization -SIVA1 Siva Apoptosis O15304 10572 14q32.33 human Y34-p 448080 RGVCAERySQEVFEK Siva apoptosis, induced 11278261 1 0 0 -FOXM1 FOXM1 DNA-binding; Transcription factor Q08050 2305 12p13.33 human T620-p 3194573 SKSVLPRtPESWRLT protein stabilization cell cycle regulation; transcription, induced 22094256; 23240008 2 8 23 -RHBG RHBG Membrane protein, integral; Membrane protein, multi-pass; Transporter; Transporter, SLC family Q9H310 57127 1q22 human Y429-p 3647000 SPPDSQHyEDQVHWQ intracellular localization; activity, inhibited 18635543 1 0 0 -SKP2 SKP2 Cell cycle regulation; UBIQUITIN LIGASE; Ubiquitin conjugating system; Ubiquitin ligase Q13309 6502 5p13.2 human S256-p 1296362400 QTLLSSCsRLDELNL molecular association, regulation; ubiquitination; enzymatic activity, induced; phosphorylation carcinogenesis, induced; cell growth, induced; cell motility, induced; transcription, induced; signaling pathway regulation CUL1(INDUCES) 30413706; 33661942 3 1 0 -NFE2L1 NFE2L1 DNA-binding; Transcription factor Q14494 4779 17q21.32 human S379-p 27971902 SQDFLLFsPEVESLP protein degradation; ubiquitination apoptosis, induced 23623971 1 0 0 -Slc12a5 KCC2 Membrane protein, integral; Membrane protein, multi-pass; Transporter; Transporter, SLC family Q91V14 57138 2|2 H3 mouse S963-p 487533 ITDESRGsIRRKNPA SLC12 intracellular localization 34445881; 34752143 23 5 2 -G3BP1 G3BP-1 Adaptor/scaffold; EC 3.6.4.12; EC 3.6.4.13; Helicase; RNA-binding Q13283 10146 5q33.1 human R447-m1 476716 GGMRGPPrGGMVQKP translation, altered 27601476 1 6 72 inhibits Stress Granules (SGs)-RNA granule assembly upon environmental stress -EPAS1 HIF2A DNA-binding; Transcription factor Q99814 2034 2p21 human K685-ac 7761202 TFKTRSAkGFGARGP transcription, inhibited 19498162 2 1 0 -FLT3 FLT3 EC 2.7.10.1; KINASE; Kinase, protein; Membrane protein, integral; Oncoprotein; Protein kinase, TK; Protein kinase, tyrosine (receptor) P36888 2322 13q12.2 human Y768-p 459389 HSEDEIEyENQKRLE PK_Tyr_Ser-Thr molecular association, regulation cell cycle regulation GRB2(INDUCES) 19438505 2 0 0 regulates cell proliferation -PRKD1 PRKD1 Autophagy; EC 2.7.11.13; KINASE; Kinase, protein; Motility/polarity/chemotaxis; Protein kinase, CAMK; Protein kinase, Ser/Thr (non-receptor) Q15139 5587 14q12 human Y463-p 448648 NDTGSRYyKEIPLSE PH protein conformation; phosphorylation; enzymatic activity, induced cell differentiation, altered; apoptosis, inhibited; transcription, induced; transcription, altered; cell growth, altered 12505989; 12637538; 15024053; 16891660; 17804414 7 0 0 angiogenesis; leads to PLC-gamma phosphorylation; activates transciption; activates PKD and induces NF-kB and IKKB activation and degradation -BLM BLM DNA repair, damage; DNA replication; EC 3.6.4.12; Helicase P54132 641 15q26.1 human S502-p 34666301 HLQKSFVsSNWAETP BDHCT_assoc protein stabilization; molecular association, regulation; intracellular localization CUL3(DISRUPTS) 25015292 1 1 0 Chk1 prevents chromatin bridges and is required for BLM localization to anaphase bridges. -Oprm1 MOR-1 GPCR, family 1; Membrane protein, integral; Membrane protein, multi-pass; Receptor, GPCR P33535 25601 1q11 rat Y106-p 455804 MKTATNIyIFNLALA 7tm_1; TM activity, inhibited 11353794 2 0 0 -Eif4ebp1 4E-BP1 Translation; Translation initiation Q62622 116636 16q12.3 rat S82-p 447525 PTIPGVTsPTSDEPP eIF_4EBP molecular association, regulation translation, altered EIF4E(DISRUPTS) 10779345 7 9 0 -HSF1 HSF1 DNA-binding; Transcription factor Q00613 3297 8q24.3 human T369-p 469243 PSPPPTStPEKCLSV Vert_HS_TF transcription, inhibited 25963659 1 15 31 under non-stressed conditions, upon heat shock S to A mutant showed 60% higher luciferase activity -LALBA LALBA Apoptosis; Secreted; Secreted, signal peptide; Transferase P00711 281894 cow S66-p 1875112301 AIVQNNDsTEYGLFQ Lys molecular association, regulation; protein conformation IGE(DISRUPTS); IgG(DISRUPTS) 34655828 0 1 0 -TAGLN TAGLN Actin-binding; Motility/polarity/chemotaxis; Nuclear receptor co-regulator Q01995 6876 11q23.3 human S181-p 469978 VIGLQMGsNRGASQA Calponin molecular association, regulation cytoskeletal reorganization ACTB(DISRUPTS) 11053353; 17123483 3 15 14 -HAUS8 HAUS8 Cell cycle regulation Q9BT25 93323 19p13.11 human S151-p 20609209 EAMEMMEsQTLLLTL intracellular localization cell cycle regulation; apoptosis, inhibited 21690413 1 0 0 localization to the spindle -ELL ELL Nuclear receptor co-regulator; Oncoprotein; Transcription initiation complex P55199 8178 19p13.11 human K29-ac 1875199400 KVSVFHVkLTDSALR ELL protein degradation 32152128 1 0 0 -TARDBP TDP-43 RNA-binding Q13148 23435 1p36.22 human S369-p 6855907 EPNQAFGsGNNSYSG protein conformation 32778941 2 0 0 -Mecp2 MECP2 Transcription, coactivator/corepressor Q9Z2D6 17257 X A7.3|X 37.63 cM mouse Y120-p 37042901 SGRSAGKyDVYLINP MBD intracellular localization cell cycle regulation; cell motility, inhibited 25527496 2 0 0 localized to the centrosome, colocalized with gamma-tubuliin and pericentrin -RARA RARA DNA-binding; Nuclear receptor; Oncoprotein; Transcription factor P10276 5914 17q21.2 human S445-p 455329 APPPGSCsPSLSPSS protein degradation; ubiquitination signaling pathway regulation 15657432; 21272161 3 2 0 retinoid signaling -RGS18 RGS18 GAP; GAP, RGS Q9NS28 64407 1q31.2 human S218-p 4772688 NLRRRSRsFTCNEFQ molecular association, regulation signaling pathway regulation 14-3-3 gamma(INDUCES); 14-3-3 gamma(DISRUPTS) 22234696; 24244663 2 9 1 Ca 2+ signaling; followed by dephosphorylation of S49 and S218 -SENP2 SENP2 DESUMOYLASE; EC 3.4.22.68; Protease; Sumo-specific protease Q9HC62 59343 3q27.2 human T369-p 40499300 TDDLLELtEDMEKEI intracellular localization apoptosis, induced 25689261 3 1 0 nuclear export -ARHGDIB RhoGDI beta Cell adhesion; G protein regulator, misc.; Motility/polarity/chemotaxis P52566 397 12p12.3 human Y130-p 4113623 LKYVQHTyRTGVKVD Rho_GDI molecular association, regulation carcinogenesis, induced; cell motility, induced RHOA(DISRUPTS); SELPLG(INDUCES); RHOC(DISRUPTS) 24055812; 32903764 2 2 31 -Cry1 CRY1 DNA-binding; Lyase; Transcription, coactivator/corepressor P97784 12952 10 C1|10 41.63 cM mouse K585-ub 50596801 GTGLSSGkRPSQEED protein degradation; ubiquitination 26431207 1 0 0 -RPS3 RPS3 Apoptosis; EC 4.2.99.18; RNA-binding; Ribosomal; Translation P23396 6188 11q13.4 human R64-m2 9184301 NVLGEKGrRIRELTA KH_2 intracellular localization 19460357 1 0 0 regulates ribosome assembly -USF1 USF1 DNA-binding; Transcription factor P22415 7391 1q23.3 human S262-p 7367003 RQSNHRLsEELQGLD molecular association, regulation; acetylation 23219531 2 1 0 increases acetylation at USF1-K235 -GRK2 GRK2 EC 2.7.11.15; KINASE; Kinase, protein; Protein kinase, AGC; Protein kinase, Ser/Thr (non-receptor) P25098 156 11q13.2 human K19-ub 1872283501 SYLMAMEkSKATPAA protein degradation 17006543 1 0 0 -CCNE1 CCNE1 Activator; Cell cycle regulation; Nuclear receptor co-regulator P24864 898 19q12 human S387-p 454413 LSEQNRAsPLPSGLL protein degradation 14536078 2 17 1 -SALL4 SALL4 iso3 C2H2-type zinc finger protein; Cancer Testis Antigen (CTA); DNA-binding Q9UJQ4-2 57167 20q13.2 human K401-sm 31089513 RAPPTYVkVEVPGTF protein stabilization; molecular association, regulation; intracellular localization transcription, induced Oct4(DISRUPTS) 23012367 1 0 0 -SOX9 SOX9 DNA-binding; Transcription factor P48434 374148 chicken S64-p 451039 DPDLKKEsDEDKFPV Sox_N sumoylation signaling pathway regulation 23382206 6 0 0 induce NCC delamination -SHARPIN SHARPIN Apoptosis Q9H0F6 81858 8q24.3 human S131-p 31885533 QNGSKSNsPPALGPE molecular association, regulation ARP2(INDUCES) 36148554 1 2 0 -Rps6ka5 MSK1 EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, AGC; Protein kinase, Ser/Thr (non-receptor) Q8C050 73086 12|12 E mouse T645-p 448217 PDNQPLKtPCFTLHY Pkinase enzymatic activity, induced 17117922 16 1 0 -AATF AATF Nucleolus; RNA-binding; Transcription factor Q9NY61 26574 17q12 human S477-p 3753303 ELIERKTsSLDPNDQ TRAUB protein stabilization; molecular association, regulation apoptosis, inhibited; transcription, altered NFkB-p65(INDUCES) DNA(INDUCES) 17157788 1 0 0 -GAB2 GAB2 Adaptor/scaffold Q9UQC2 9846 11q14.1 human T391-p 448383 ATIPRRNtLPAMDNS molecular association, regulation; intracellular localization; activity, inhibited; phosphorylation cell growth, altered 14-3-3 beta(INDUCES); SHC1(DISRUPTS); GRB2(DISRUPTS); EGFR(DISRUPTS) 19172738 2 23 54 -Npm1 NPM1 Nucleolus; Oncoprotein; RNA-binding; Translation Q61937 18148 11|11 A4 mouse K27-ac 33347943 GCELKADkDYHFKVD Nucleoplasmin molecular association, regulation; intracellular localization MDM2(DISRUPTS) 33495326 1 4 2 Deacetylation of NPM1 at K27 and K54 leads to release of NPM from nucleoli and its association with HDM2. As a result HDM2-mediated proteasomal degradation of p53 is inhibited -CD84 CD84 Cell surface; Immunoglobulin superfamily; Membrane protein, integral; Motility/polarity/chemotaxis Q9UIB8 8832 1q23.3 human Y279-p 450870 AASKKTIyTYIMASR molecular association, regulation cell growth, altered SH2D1B(INDUCES); SH2D1A(INDUCES) 12928397 1 9 295 -Braf BRAF EC 2.7.11.1; KINASE; Kinase, protein; Oncoprotein; Protein kinase, Ser/Thr (non-receptor); Protein kinase, TKL F1M9C3 114486 4q22 rat S345-p 4273552 QFGQRDRsSSAPNVH phosphorylation 26333016 2 9 25 constitutively phosphorylated -KIF11 KIF11 Microtubule-binding; Motor P52732 3832 10q23.33 human T926-p 448410 LDIPTGTtPQRKSYL Microtub_bind molecular association, regulation; intracellular localization cell cycle regulation ERCC2(INDUCES) 21642957; 35977011; 8548803 8 29 2 helps in centrosome separation and normal progression through mitosis; regulates association with the spindle apparatus -USP7 USP7 DEUBIQUITINASE; EC 3.4.19.12; Protease; Ubiquitin conjugating system; Ubiquitin-specific protease Q93009 7874 16p13.2 human S18-p 449238 KAGEQQLsEPEDMEM protein stabilization; enzymatic activity, induced cell cycle regulation; DNA repair, inhibited; signaling pathway regulation 22361354; 28418900 2 63 5 inhibits ubiquitination and induces stability of itself and mdm2 and induces degradation of p53, regulates DNA damage signal transduction pathway -PKMYT1 Myt1 EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, Other; Protein kinase, Ser/Thr (non-receptor); Protein kinase, dual-specificity (non-receptor) Q99640 9088 16p13.3 human T412-p 11331001 QPLGPPAtPPGSPPC molecular association, regulation PIN1(INDUCES) 10504341 1 0 0 -RCHY1 RCHY1 EC 6.3.2.-; EC 6.3.2.19; Nuclear receptor co-regulator; UBIQUITIN LIGASE; Ubiquitin conjugating system; Ubiquitin ligase Q96PM5 25898 4q21.1 human S155-p 483982 CLEDIHTsRVVAHVL zf-RING_2 ubiquitination; intracellular localization; enzymatic activity, inhibited cell growth, altered p53(DISRUPTS) 17568776 1 1 0 cytoplasmic localization -Mbp MBP iso5 Cytoskeletal P04370-5 17196 18 E3|18 55.84 cM mouse T96-p 450929 KNIVTPRtPPPSQGK Myelin_MBP protein stabilization; molecular association, regulation; intracellular localization cytoskeletal reorganization Fyn(DISRUPTS) 21887699; 23861868 14 14 7 -Glul GLUL Amino Acid Metabolism - alanine, aspartate and glutamate; Amino Acid Metabolism - arginine and proline; EC 4.1.1.15; EC 6.3.1.2; Energy Metabolism - nitrogen; Ligase P15105 14645 1|1 G3 mouse T301-p 15501403 LDNARRLtGFHETSN enzymatic activity, inhibited 31178690 1 3 2 -Bad BAD Apoptosis O35147 64639 1q43 rat S129-p 447861 EGMEEELsPFRGRSR Bcl-2_BAD molecular association, regulation apoptosis, induced 14-3-3 zeta(DISRUPTS) 12049737 7 10 36 -USP25 USP25 DEUBIQUITINASE; EC 3.4.19.12; Protease; Ubiquitin conjugating system; Ubiquitin-specific protease Q9UHP3 29761 21q21.1 human K99-sm 3084637 IDLTGDDkDDLQRAI UIM ubiquitination; enzymatic activity, inhibited 18538659 1 1 0 sumoylation inhibits ubiquitin chain hydrolysis and has reduced afinity to ubiquitin chains -NPAT NPAT Cell cycle regulation; Transcription regulation Q14207 4863 11q22.3 human T1350-p 2286401 ISRTTSAtPLKDNTQ NPAT_C transcription, induced 10995387 1 4 5 multiple sites deletion mutant -GABRB3 GABRB3 Channel, chloride; Channel, ligand-gated; Membrane protein, integral; Membrane protein, multi-pass; Transporter; Transporter, ion channel P28472 2562 15q12 human S432-p 450245 KTHLRRRsSQLKIKI Neur_chan_memb receptor internalization, inhibited apoptosis, inhibited 24513087 12 0 0 -XRCC3 XRCC3 DNA repair, damage O43542 7517 14q32.33 human S225-p 482710 PFRCEFDsQASAPRA Rad51 activity, induced cell cycle regulation; DNA repair, induced; signaling pathway regulation 23438602 1 1 0 XRCC3 phosphorylation is important for cellular resistance; ATR/ATM pathway -ACP1 ACP1 Cofactor and Vitamin Metabolism - riboflavin; EC 3.1.3.2; EC 3.1.3.48; Motility/polarity/chemotaxis; PHOSPHATASE; Phosphatase (non-protein); Protein phosphatase, tyrosine (non-receptor) P24666 52 2p25.3 human Y133-p 457445 LIIEDPYyGNDSDFE LMWPc molecular association, regulation; phosphorylation; enzymatic activity, induced cell motility, altered; cell adhesion, altered; cell growth, altered GRB2(INDUCES) 10671492; 10980198; 16890200; 9038134 5 6 81 -YTHDF2 YTHDF2 RNA processing; RNA-binding Q9Y5A9 51441 1p35.3 human T381-p 6223825 SQAGSGStPSEPHPV protein stabilization carcinogenesis, induced; cell growth, induced; apoptosis, inhibited; RNA stability, inhibited 33420027 1 0 3 -Mapt Tau ACETYLTRANSFERASE; Acetyltransferase; Cytoskeletal P10637 17762 11 67.79 cM|11 E1 mouse K572-ac 25223700 GKVQIINkKLDLSNV Tubulin-binding acetylation; phosphorylation 33910013 13 2 0 required for acetylation and phosphorylation -RELA NFkB-p65 DNA-binding; Nuclear receptor co-regulator; Transcription factor Q04206 5970 11q13.1 human K37-me 31094535 RGMRFRYkCEGRSAG RHD_DNA_bind transcription, induced 23904479 2 0 0 differential regulation of gene expression -KIF20A KIF20A Microtubule-binding; Motor O95235 10112 5q31.2 human S21-p 4921068 SDDDVVVsPMFESTA molecular association, regulation; intracellular localization; protein conformation cell cycle regulation INCENP(DISRUPTS) 24656812 1 4 0 favours solubility, inhibits microtubule binding -PARP1 PARP1 DNA repair, damage; EC 2.4.2.30; Nuclear envelope; Nuclear receptor co-regulator; Nucleolus; Transferase P09874 142 1q42.12 human K949-ub 12324641 PKGKHSVkGLGKTTP PARP protein degradation 31616951 1 2 7 -Eif3f eIF3-epsilon EC 3.4.19.12; Translation; Translation initiation Q9DCH4 66085 7|7 E3 mouse K258-ub 7388006 IGVDLIMkTCFSPNR MitMem_reg protein degradation 19073596 1 0 0 regulates skeletal muscle atrophy -PDIK1L CLIK1L EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, Other; Protein kinase, Ser/Thr (non-receptor) Q8N165 149420 1p36.11 human S194-p 56663329 KVADFGLsKVCSASG Pkinase enzymatic activity, induced carcinogenesis, inhibited; cell growth, inhibited 35021089 1 1 0 -Gjd2 GJD2 Cell adhesion; Channel, misc.; Membrane protein, integral; Membrane protein, multi-pass O54851 14617 2|2 E4 mouse S110-p 471386 KQRERRYsTVFLALD Connexin activity, inhibited neural plasticity 16956882 1 2 2 adaptation to ambient light conditions; regulating gap junction communication -SAFB SAFB1 DNA-binding; Nuclear receptor co-regulator; RNA-binding Q15424 6294 19p13.3 human K231-sm 15511917 TCKSEPVkEESSELE molecular association, regulation transcription, inhibited HDAC3(INDUCES) 21527249 1 4 0 -HTT Huntingtin Cytoskeletal P42858 3064 4p16.3 human K9-ub 1877148901 ATLEKLMkAFESLKS ubiquitination 32675242 1 0 0 K6 and K9 sites were ubquitinated in WT were mutated to R and slowed aggregation and reduce size, but increase in smaller size aggregates but increased death rates. -Nfkb2 NFkB-p100 DNA-binding; Oncoprotein; Transcription factor Q5U2Z4 309452 1q54 rat S868-p 450167 KEDSAYGsQSVEQEA apoptosis, inhibited 21550382 7 1 1 induces cell survival -NEDD1 NEDD1 Cell cycle regulation Q8NHV4 121441 12q23.1 human S397-p 4272994 GKNQDFSsFDDTGKS molecular association, regulation cell cycle regulation 19509060 2 14 1 important for binding of NEDD1 with gamma-tubulin -Cebpb C/EBP-beta DNA-binding; Motility/polarity/chemotaxis; Transcription factor P21272 24253 3q42 rat S273-p 13373502 QKKVEQLsRELSTLR bZIP_2 molecular association, regulation cell cycle regulation; transcription, induced C/EBP-beta(INDUCES) DNA(INDUCES) 20351173 1 1 1 -GATA3 GATA3 Transcription factor P23771 2625 10p14 human S308-p 456464 IKPKRRLsAARRAGT activity, induced; protein degradation cell growth, induced; transcription, induced DNA(INDUCES) 16109788; 25479686; 28498822 4 0 0 -EMSY EMSY DNA repair, damage; Transcription regulation Q7Z589 56946 11q13.5 human S209-p 453526 RKRRRTNsSSSSPVV transcription, induced 22315412 3 38 194 IFN-stimulated genes induced, including mammary and ovarian carcinoma cell lines, inhibits viral replication -Camk2a CAMK2A EC 2.7.11.17; KINASE; Kinase, protein; Protein kinase, CAMK; Protein kinase, Ser/Thr (non-receptor) P11798 12322 18 E1|18 34.41 cM mouse T306-p 449596 LKGAILTtMLATRNF molecular association, regulation; enzymatic activity, inhibited; intracellular localization; phosphorylation neural plasticity NMDAR2B(DISRUPTS); Calmodulin(DISRUPTS) 12408851; 28636948; 33853773 18 10 2 regulates phosphorylation at T286 and of GluA1 at S831; inhibits phosphorylation at T286, regulates LTP, fear memory, spatial learning -YAP1 YAP1 Oncoprotein; Transcription, coactivator/corepressor P46937 10413 11q22.1 human K280-ub 964556212 ISQSAPVkQPPPLAP protein degradation carcinogenesis, altered; carcinogenesis, inhibited; cell growth, inhibited 31393050; 36271031 2 2 0 -SUPT5H SPT5 RNA-binding; Transcription, coactivator/corepressor O00267 6829 19q13.2 human R698-m2 475966 SGGMSRGrGRRDNEL transcription, inhibited 12718890 1 0 0 inhibition of in vitro transcription assays and HIV-1 gene expression -Brsk2 BRSK2 EC 2.7.11.1; EC 2.7.11.26; KINASE; Kinase, protein; Protein kinase, CAMK; Protein kinase, Ser/Thr (non-receptor) Q69Z98 75770 7|7 F5 mouse S436-p 4734879 PRVTPHPsPRGSPLP protein stabilization; enzymatic activity, inhibited; phosphorylation 23790753 1 8 0 inhibits axon branching (activated in BRSK2 18A mutant) -S100A4 S100A4 Calcium-binding; Cell development/differentiation P26447 6275 1q21.3 human K96-sm 25352006 FFEGFPDkQPRKK__ intracellular localization transcription, induced 20685652 1 0 0 -CLCN2 CLCN2 Channel, chloride; Membrane protein, integral; Membrane protein, multi-pass; Transporter; Transporter, ion channel P51788 1181 3q27.1 human S76-p 2902201 CARCRVCsVRCHKFL activity, induced 15358127 1 0 0 -PEA15 PEA-15 Apoptosis; Motility/polarity/chemotaxis Q15121 8682 1q23.2 human S116-p 450281 KDIIRQPsEEEIIKL molecular association, regulation; protein stabilization; intracellular localization; protein conformation carcinogenesis, induced; autophagy, induced; cell motility, induced; apoptosis, inhibited; transcription, induced; autophagy, altered; signaling pathway regulation FADD(INDUCES) 12808093; 17227770; 17700518; 20452983; 21285289; 25416196; 30569123; 33574916; 34241740; 34615962; 34997083 15 95 1092 -SF1 SF1 RNA splicing; RNA-binding; Spliceosome; Transcription, coactivator/corepressor Q15637 7536 11q13.1 human S20-p 449919 PSKKRKRsRWNQDTM SF1-HH protein conformation RNA splicing, altered U2AF1(DISRUPTS) 12718882 2 3 0 The structure of the complex suggests that a combination of steric interference and unfavorable electrostatic contacts of the phosphorylated S20 with the negatively charged helix A in U2AF-RMM3/SF1. -Gata1 GATA1 DNA-binding; Transcription factor P17679 14460 X A1.1|X 3.59 cM mouse S310-p 451231 QTRNRKAsGKGKKKR protein degradation; acetylation; ubiquitination; phosphorylation cell differentiation, altered; transcription, induced DNA(INDUCES) 16204311; 16858405 10 0 0 Phosphorylation and acetylation cause the degradation of acetylated GATA-1; S310A acts like a dominant negative mutation on EpoR-induced differentiation.; DNA binding is required for MAPK-dependent phosphorylation -ERG ERG DNA-binding; Oncoprotein; Transcription factor P11308 2078 21q22.2 human S215-p 9429097 VDKALQNsPRLMHAR protein conformation cell motility, induced; transcription, induced 23918819; 25885538; 28887309 3 13 2 S215 and the FXFP motif required to promote prostate cell migration and activate target genes -GRIK2 GluR6 Channel, calcium; Channel, ligand-gated; Membrane protein, integral; Membrane protein, multi-pass Q13002 2898 6q16.3 human S846-p 11496000 VGEFLYKsKKNAQLE sumoylation; intracellular localization; phosphorylation; palmitoylation endocytosis, altered 37868810 5 0 0 palmitoylation maintains surface expression and regulates agonist -induced internalisation -ICAM3 ICAM3 Cell adhesion; Immunoglobulin superfamily; Membrane protein, integral P32942 3385 19p13.2 human S525-p 451213 SYHVREEsTYLPLTS molecular association, regulation; intracellular localization NHERF(NOT_REPORTED) 11784723 1 1 14 -PGR PR DNA-binding; Nuclear receptor; Transcription factor P06401 5241 11q22.1 human S81-p 450160 TQDQQSLsDVEGAYS Prog_receptor molecular association, regulation carcinogenesis, induced; cell growth, induced; transcription, induced DNA(INDUCES) 21518957; 23921636; 8662865 5 3 0 -PLAG1 PLAG1 C2H2-type zinc finger protein; DNA-binding; Oncoprotein; Transcription factor Q6DJT9 5324 8q12.1 human K263-sm 3568001 CNVSVPIkDELLPVM intracellular localization cell growth, induced; transcription, inhibited 15208321; 16207715 2 0 0 -Arrb2 ARRB2 Adaptor/scaffold P29067 25388 10q24 rat S14-p 23083983 TRVFKKSsPNCKLTV activity, induced; molecular association, regulation; protein conformation ADRB2(INDUCES); GRK2(INDUCES) 31948726 2 1 1 induces pre-active state -DOK1 DOK1 Adaptor/scaffold; Motility/polarity/chemotaxis Q99704 1796 2p13.1 human S443-p 454883 ATGSGIKsHNSALYS cell motility, induced; cell growth, inhibited 15574499 1 0 0 -NFKBIB IkB-beta Inhibitor Q15653 4793 19q13.2 human S315-p 452014 SGPCSSSsDSDSGDE activity, induced; intracellular localization transcription, inhibited; transcription, altered CCDC32(INDUCES) 12732617; 8887627; 9278383 3 0 0 Phosphorylation blocks NF-kB-directed transcription.; and in vivo, NFkB/Rel activation -KRAS KRas G protein; G protein, monomeric; G protein, monomeric, Ras; Motility/polarity/chemotaxis; Oncoprotein P01116 3845 12p12.1 human K104-ac 35480405 REQIKRVkDSEDVPM Ras molecular association, regulation; intracellular localization; enzymatic activity, inhibited; protein conformation carcinogenesis, inhibited; cell growth, inhibited; cell motility, inhibited RAF1(DISRUPTS) 22711838; 23723075; 30792310; 33060649 6 3 0 hampered GEF binding, inhibition of NPIPA2, DUSP1 and IL6 expression in lung and ovarian cancer cells, reduced invasion -SNPH syntaphilin iso2 Membrane protein, integral; Vesicle O15079-2 9751 20p13 human T63-p 23150253 SAGSRRRtSPPVSVR Syntaphilin cell growth, induced 34087103 1 1 2 -MAPT Tau iso8 ACETYLTRANSFERASE; Acetyltransferase; Cytoskeletal P10636-8 4137 17q21.31 human S305-p 487457 KHVPGGGsVQIVYKP Tubulin-binding molecular association, regulation 21204788 4 4 0 in vitro microtubule binding -ARHGEF4 ARHGEF4 iso3 GEF; GEF, Rac/Rho; Motility/polarity/chemotaxis Q9NR80-3 50649 2q21.1 human Y94-p 3333400 VGSEEDLyDDLHSSS activity, induced 18653540 1 0 0 important for EGF-induced activation of Rac1 and Cdc42 -Myog myogenin DNA-binding; Transcription factor P12979 17928 1 E4|1 58.18 cM mouse S43-p 1880114100 ERTELSLsPEARGPL protein degradation; molecular association, regulation; ubiquitination transcription, inhibited FBXO32(INDUCES) 36259412 1 0 0 -Ubb UBB Apoptosis; Cell cycle regulation; Cell development/differentiation; Motility/polarity/chemotaxis; Transcription regulation; Ubiquitin-like modifier P0CG49 22187 11 B2|11 38.46 cM mouse K63-ub 19008158 LSDYNIQkESTLHLV ubiquitin molecular association, regulation DNA repair, induced; chromatin organization, altered BRCA1(INDUCES); 53BP1(INDUCES) 25578731 1 14 108 -METTL14 METTL14 EC 2.1.1.62; METHYLTRANSFERASE; Methyltransferase Q9HCE5 57721 4q26 human S399-p 15427105 IERLRPKsPPPKSKS molecular association, regulation METTL3(INDUCES) 27281194 1 14 7 -CEP76 CEP76 Q8TAP6 79959 18p11.21 human S83-p 2048409 VEQELPSsPKQPICF cell cycle regulation 27065328 1 23 3 suppresses centriole ampli?cation in S phase -IKBKG IKKG Adaptor/scaffold; Protein kinase, regulatory subunit Q9Y6K9 8517 Xq28 human Y374-p 473650 PLPPAPAyLSSPLAL enzymatic activity, inhibited; phosphorylation signaling pathway regulation 23131831 1 0 13 modulates IFKB phosphorylation; regulation of TCR mediated calcium (Ca2+) influx; NF-kB pathway -Cbl CBL Adaptor/scaffold; EC 6.3.2.-; EC 6.3.2.19; Ligase; Motility/polarity/chemotaxis; Oncoprotein; UBIQUITIN LIGASE; Ubiquitin conjugating system; Ubiquitin ligase P22682 12402 9 A5.1-A5.2|9 24.72 cM mouse Y780-p 448531 SENEDDGyDVPKPPV molecular association, regulation cytoskeletal reorganization Src(INDUCES) 34019873 16 4 257 -Notch1 Notch 1 Membrane protein, integral; Motility/polarity/chemotaxis; Oncoprotein; Receptor, misc.; Transcription factor Q01705 18128 2 A3|2 18.91 cM mouse K2164-ac 18899510 ACGSKEAkDLKARRK protein stabilization; ubiquitination 21499261 2 1 0 -NUMA1 NuMA-1 Cell cycle regulation; Motility/polarity/chemotaxis Q14980 4926 11q13.4 human T2055-p 472502 MAFSILNtPKKLGNS cytoskeletal reorganization 23921553 4 28 16 cortical NuMA/dynein localization, proper metaphase spindle positioning -Myo3b MYO3B Actin-binding; EC 2.7.11.1; KINASE; Kinase, protein; Motor; Protein kinase, STE; Protein kinase, Ser/Thr (non-receptor) Q1EG27 329421 2|2 C2 mouse T178-p 36841906 STRLRRNtSVGTPFW Pkinase enzymatic activity, induced 21895655 1 1 0 -HSP90AA1 HSP90A Chaperone; Heat shock protein P07900 3320 14q32.31 human K558-ac 2884405 LPEDEEEkKKQEEKK HSP90 molecular association, regulation carcinogenesis, induced; exocytosis, induced CHIP(DISRUPTS); TEBP(DISRUPTS); HSP70(DISRUPTS); MMP2(INDUCES); HSP40(DISRUPTS) 18559531 1 4 1 -AIMP2 JTV1 Translation; Translation regulation Q13155 7965 7p22.1 human S156-p 55571504 LSTVHTHsSVKSVPE Thioredoxin_16 molecular association, regulation; intracellular localization cell growth, inhibited EPRS(DISRUPTS) 27197155 1 0 0 nuclear localization; reduced association with MSC -P2RY2 P2Y2 GPCR, family 1; Membrane protein, integral; Membrane protein, multi-pass; Receptor, GPCR; Receptor, misc. P41231 5029 11q13.4 human T344-p 2909201 GLRRSDRtDMQRIED receptor desensitization, altered; intracellular localization 16311903 2 0 0 -Srsf5 SFRS5 RNA processing; RNA-binding; Spliceosome Q09167 29667 6q24 rat S86-p 3685800 GRGRGRYsDRFSSRR RNA splicing, altered 15684423 2 5 0 -YWHAQ 14-3-3 theta Adaptor/scaffold P27348 10971 2p25.1 human S232-p 456053 LTLWTSDsAGEECDA protein conformation apoptosis, induced 25862939 4 16 0 cell survival inhibited, BAX oligomerization induced -BTG1 BTG1 Cell cycle regulation; Oncoprotein P62324 694 12q21.33 human S159-p 457381 ELLLGRTsPSKNYNM molecular association, regulation cell growth, altered CAF-1A(INDUCES) 9820826 1 5 2 -Pebp1 RKIP Lipid-binding; Protein kinase, regulatory subunit P31044 29542 12q16 rat S51-p 3189670 TQVMNRPsSISWDGL PBP enzymatic activity, inhibited; phosphorylation; enzymatic activity, induced signaling pathway regulation 35696587 1 11 8 regulates ?-AR signaling through inhibition of GRK2 activity,; primes phosphorylation at S153 further enhancing PKA activity -EP300 p300 ACETYLTRANSFERASE; Acetyltransferase; EC 2.3.1.48; Motility/polarity/chemotaxis; Nuclear receptor co-regulator; Transcription, coactivator/corepressor Q09472 2033 22q13.2 human S12-p 25126714 VVEPGPPsAKRPKLS acetylation; molecular association, regulation; enzymatic activity, induced cell differentiation, induced; transcription, induced; signaling pathway regulation CTNNB1(INDUCES) 22465714; 33355181 2 6 0 C/EBP-beta acetylation induced, induces cancer-associated muscle wasting; Wnt/Beta- catenin signaling pathway -TOP1 TOP1 EC 5.99.1.2; Isomerase; Nucleolus; Oncoprotein P11387 7150 20q12 human S21-p 2721301 ADFRLNDsHKHKDKH enzymatic activity, induced 18408216 1 4 0 enhances DNA relaxation activity in vitro -TIMP2 TIMP2 Cell development/differentiation; Extracellular matrix; Inhibitor; Motility/polarity/chemotaxis; Secreted; Secreted, signal peptide P16035 7077 17q25.3 human Y90-p 1257779601 EKDIEFIyTAPSSAV TIMP molecular association, regulation MMP2(INDUCES) 30227959 1 0 0 -HECTD3 HECTD3 EC 6.3.2.-; EC 6.3.2.19; Ligase; UBIQUITIN LIGASE; Ubiquitin conjugating system; Ubiquitin ligase Q5T447 79654 1p34.1 human S192-p 150180311 TYSHRLGsRPQPAEA molecular association, regulation apoptosis, inhibited CASP9(INDUCES) 28716524 1 1 0 -Lat2 LAB Adaptor/scaffold; Membrane protein, integral Q9JHL0 56743 5|5 G2 mouse Y139-p 450963 EDDDSNSyENVLVCK LAT2 signaling pathway regulation 22308309 3 10 169 plays a negative role in TCR and FcRI-mediated and no role in LPS-mediated signaling -Camk2b CAMK2B EC 2.7.11.17; KINASE; Kinase, protein; Protein kinase, CAMK; Protein kinase, Ser/Thr (non-receptor) P08413 24245 14q21 rat S327-p 48915806 TTAPATMsTAASGTT molecular association, regulation 26291163 1 1 0 inhibits interaction with F-actin, regulates synaptic plasticity -Nfkbib IkB-beta Inhibitor Q60778 18036 7|7 B1 mouse S23-p 447916 WCDSGLGsLGPDAAA protein degradation 10497169; 9092533 6 0 0 -TRIM28 TIF1B EC 6.3.2.-; KINASE; Kinase, protein; Ligase; Nuclear receptor co-regulator; Protein kinase, atypical; SUMO LIGASE; SUMO ligase; Transcription, coactivator/corepressor; UBIQUITIN LIGASE; Ubiquitin conjugating system; Ubiquitin ligase Q13263 10155 19q13.43 human K750-sm 3142606 IRARLQEkLSPPYSS transcription, inhibited 31391303 2 8 0 loss of TF1B sumoylation induces dsRNA-activated IFN-mediated defenses that rely on RIG-I, MAVS, TBK1, and JAK1 transcription, SUMOylated TIF1B Is required to support efficient virus replication -Plcb3 PLCB3 Carbohydrate Metabolism - inositol phosphate; EC 3.1.4.11; Phospholipase Q99JE6 29322 1q43 rat S1105-p 448448 LDRKRNNsISEAKTR PLC-beta_C intracellular localization; enzymatic activity, inhibited 11278298; 15998840 5 22 216 -Ppp1r1b DARPP-32 Motility/polarity/chemotaxis; Protein phosphatase, regulatory subunit Q6J4I0 360616 10q31 rat S45-p 465607 LFRVSEHsSPEEESS DARPP-32 protein conformation 8226946 2 7 4 PKA phosphorylation did not alter fluorescence parameters, and only minor effects were associated with casein kinase II -PXN PXN iso2 Adaptor/scaffold; Cell adhesion; Cytoskeletal; Motility/polarity/chemotaxis P49023-2 5829 12q24.23 human S83-p 451113 FIHQQPQsSSPVYGS Paxillin cell cycle regulation; carcinogenesis, altered; transcription, altered 20628053 7 40 44 regulates Erk1/2-induced cell proliferation and transcription -Rptor Raptor Adaptor/scaffold Q8K4Q0 74370 11|11 E2 mouse S696-p 11315003 EKNYPLPsPAATEGG molecular association, regulation signaling pathway regulation PRAS40(INDUCES); p70S6K(INDUCES) 24239769 8 11 1 mechanical stress-induced mTOR signaling -ASIC1 ASIC1 iso1 Channel, cation; Membrane protein, integral; Membrane protein, multi-pass; Transporter; Transporter, ion channel P78348-1 41 12q13.12 human S525-p 449558 QKEAKRSsADKGVAL molecular association, regulation PICK1(DISRUPTS) 12578970 2 0 0 -REL REL Oncoprotein; Transcription factor Q04864 5966 2p16.1 human S526-p 1980800 LENPSCNsVLDPRDL activity, induced transcription, induced 16585559 1 0 0 Double mutant S491A S494 is not responsive to NIK-induced activation of transcription at the IL-2 promoter. The comparable site to S494 in mouse Rel is an alanine, so S491 may be the more important residue. -RPS6KA1 p90RSK EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, AGC; Protein kinase, Ser/Thr (non-receptor); Translation Q15418 6195 1p36.11 human T573-p 447993 AENGLLMtPCYTANF Pkinase molecular association, regulation; protein conformation; enzymatic activity, induced signaling pathway regulation GSK3B(INDUCES); p90RSK(INDUCES) 12917346; 25730857; 28574827; 37059179 20 16 180 morphine-inhibited insulin receptor signaling -DRD2 DRD2 GPCR, family 1; Membrane protein, integral; Membrane protein, multi-pass; Receptor, GPCR P14416 1813 11q23.2 human K241-ub 4793400 AHLRAPLkGNCTHPE 7tm_1 protein degradation 32572597 2 0 0 -CACB CACNA1C Channel, calcium; Membrane protein, integral; Membrane protein, multi-pass P15381 100101555 rabbit T1704-p 17620920 RAISGDLtAEEELDK CAC1F_C activity, induced 20876873; 28295363; 36215501 9 1 0 induces CaV1.2 activity -SLC4A4 SLC4A4 Membrane protein, integral; Membrane protein, multi-pass; Transporter; Transporter, SLC family Q9Y6R1 8671 4q13.3 human S233-p 4699760 DIGKTVSsASRMFTN Band_3_cyto protein conformation; activity, inhibited 30377224 1 6 3 -Rrad RRAD G protein; G protein, monomeric; G protein, monomeric, RGK O88667 56437 8|8 D3 mouse S299-p 457398 KMAFRAKsKSCHDLS molecular association, regulation; intracellular localization 14-3-3 beta(DISRUPTS) 17605760 2 2 0 -TCOF1 treacle Nucleolus; RNA-binding; Transcription, coactivator/corepressor Q13428 6949 5q32-q33.1 human S1199-p 20622158 EDDVVAPsQSLLSGY molecular association, regulation; intracellular localization NBS1(INDUCES) 25512513 1 3 0 nucleolar localization -SIK1 SIK EC 2.7.11.1; KINASE; Kinase, protein; Motility/polarity/chemotaxis; Protein kinase, CAMK; Protein kinase, Ser/Thr (non-receptor); Tumor suppressor P57059 150094 21q22.3 human S435-p 7445611 VFRPRPVsPSSLLDT protein degradation; molecular association, regulation; ubiquitination; intracellular localization; enzymatic activity, inhibited; phosphorylation carcinogenesis, induced; apoptosis, altered; cell growth, induced; transcription, induced; signaling pathway regulation 14-3-3 zeta(INDUCES); 14-3-3 epsilon(INDUCES); 14-3-3 eta(INDUCES); PIN1(INDUCES); 14-3-3 beta(INDUCES); 14-3-3 theta(INDUCES); 14-3-3 gamma(INDUCES); ITCH(INDUCES) 36806887 2 11 4 -BLM BLM DNA repair, damage; DNA replication; EC 3.6.4.12; Helicase P54132 641 15q26.1 human S304-p 467231 DTDFVPPsPEEIISA BLM_N molecular association, regulation TOPBP1(INDUCES) 25794620 2 4 2 genome stability- suppression of sister chromatid exchanges -SLC40A1 SLC40A1 Membrane protein, integral; Membrane protein, multi-pass; Transporter; Transporter, SLC family Q9NP59 30061 2q32.2 human K240-sm 1881493600 LAVKAGLkEEETELK sumoylation; ubiquitination; intracellular localization 33490642 1 0 0 Sumoylation of K240E mutation impedes Fpn trafficking and is diffused throughout the cytoplasm, and affects iron homeostasis. -Pparg PPAR-gamma DNA-binding; Nuclear receptor; Transcription factor P37238 19016 6 E3|6 53.41 cM mouse K395-sm 12004433 FGDFMEPkFEFAVKF Hormone_recep activity, inhibited cell differentiation, inhibited 34249943 8 0 0 SENP3 desumoylated PPAR-gamma and enhanced its activity to promote-the expression of adipogenic marker genes such as C/EBPa, adiponectin and FABP4 -MCU MCU Membrane protein, integral; Membrane protein, multi-pass; Mitochondrial Q8NE86 90550 10q22.1 human K332-ac 466738 AQAEMDLkRLRDPLQ apoptosis, induced 35636016 1 3 42 increase of mitochondrial Ca2+ iflux and the loss of mitochondrial membrane potential (MMP), INZ treatment significantly induced cell apoptosis in tumor tissues -HSPB8 HSPB8 Heat shock protein Q9UJY1 26353 12q24.23 human S24-p 2201402 RRDPFRDsPLSSRLL protein conformation 21526341 2 16 0 decrease chaperone activity -PLK1 PLK1 EC 2.7.11.21; KINASE; Kinase, protein; Protein kinase, Other; Protein kinase, Ser/Thr (non-receptor) P53350 5347 16p12.2 human S99-p 63280100 PHQREKMsMEISIHR Pkinase cell cycle regulation 28351953 1 0 0 mitotic acceleration -KLRC1 NKG2A Membrane protein, integral; Receptor, misc. P26715 3821 12p13.2 human Y8-p 455555 MDNQGVIySDLNLPP molecular association, regulation; intracellular localization SHP-1(INDUCES) 12165520 1 0 0 -RARA RARA DNA-binding; Nuclear receptor; Oncoprotein; Transcription factor P10276 5914 17q21.2 human S461-p 455330 RSSPATHsP______ protein degradation; ubiquitination signaling pathway regulation 15657432; 21272161 3 0 0 retinoid signaling -SEPTIN12 SEPT12 Cell cycle regulation; Cytoskeletal; Hydrolase Q8IYM1 124404 16p13.3 human S198-p 63250400 PVIARADsLTMEERE Septin molecular association, regulation; protein conformation SEPT7(DISRUPTS) 28346465 1 1 0 loss of the sperm annulus/septin ring and poor male fertility -TNIP1 TNIP1 Transcription regulation Q15025 10318 5q33.1 human S123-p 1880462802 PPSSGTSsEFEVVTP protein degradation; molecular association, regulation; ubiquitination autophagy, induced; transcription, induced LC3B(INDUCES); LC3C(INDUCES); GABARAPL2(INDUCES) 36574265 1 1 0 -XRCC4 XRCC4 DNA repair, damage Q13426 7518 5q14.2 human S327-p 3195416 SLETLRNsSPEDLFD XRCC4 ubiquitination; intracellular localization DNA repair, induced DNA(INDUCES) 26774286 2 11 1 recruitment to DNA damage sites -Tnp2 TP2 DNA-binding P11101 24840 10q11 rat K93-ac 10769111 EGKVSKRkAVRRRKR TP2 molecular association, regulation chromatin organization, altered NPM3(DISRUPTS) 19710011 1 1 0 -Nphs1 NPHS1 Cell adhesion; Immunoglobulin superfamily; Membrane protein, integral Q9QZS7 54631 7|7 B1 mouse S1160-p 1876873800 YYSMRDFsPQLPPTL molecular association, regulation endocytosis, induced PICK1(INDUCES); PKCA(INDUCES) 35451598 1 0 0 -Yy1 YY1 C2H2-type zinc finger protein; Cell development/differentiation; Transcription factor Q00899 22632 12 F1|12 59.58 cM mouse K392-ac 1881842000 CPFDGCNkKFAQSTN molecular association, regulation transcription, induced DNA(DISRUPTS) 35024765 1 1 0 -IRF3 IRF3 DNA-binding; Transcription factor Q14653 3661 19q13.33 human T180-p 28095000 SPSLDNPtPFPNLGP molecular association, regulation transcription, inhibited IRF7(INDUCES) 23685991; 24275658 3 1 0 Formation of IRF3:IRF7 dimers -TNKS TNKS EC 2.4.2.30; Transferase O95271 8658 8p23.1 human T982-p 471334 SLISPAStPSCLSAA protein stabilization; intracellular localization; enzymatic activity, induced cell cycle regulation; cell growth, induced 21818122 2 0 0 -EDNRA EDNRA GPCR, family 1; Membrane protein, integral; Membrane protein, multi-pass; Motility/polarity/chemotaxis; Receptor, GPCR P25101 1909 4q31.22-q31.23 human S391-p 2911717 LCCCCYQsKSLMTSV receptor desensitization, induced 24064210 1 1 0 Lack of S397, T403 and S404 influences desensitization to a greater extent compared than S391, S393, and T396 -CD247 CD3Z Membrane protein, integral; Receptor, misc. P20963 919 1q24.2 human Y142-p 448932 GKGHDGLyQGLSTAT ITAM molecular association, regulation; intracellular localization; protein conformation; phosphorylation carcinogenesis, inhibited; cell growth, induced; signaling pathway regulation PI4K2A(INDUCES); SHC1(INDUCES) 16337488; 16919488; 19229850; 23202272; 30131370; 33676898 15 24 410 induces T- cell activation -TIAM1 TIAM1 GEF; GEF, Rac/Rho; Motility/polarity/chemotaxis; Oncoprotein Q13009 7074 21q22.11 human S172-p 11485306 FKKKRSKsADIWRED protein stabilization; molecular association, regulation 14-3-3 beta(INDUCES) 25746002 2 4 0 -EPOR EPOR Membrane protein, integral; Receptor, cytokine P19235 2057 19p13.2 human Y454-p 455531 PTPPHLKyLYLVVSD molecular association, regulation apoptosis, inhibited SHIP(INDUCES); SOCS3(INDUCES) 10660611; 12027890; 14662339 6 0 0 -ACTB ACTB Cytoskeletal; Motility/polarity/chemotaxis P60709 60 7p22.1 human K328-ac 3814584 APSTMKIkIIAPPER Actin molecular association, regulation TPM1(DISRUPTS); MYO3B(INDUCES) 32873710 1 6 20 K328 modulates muscle contraction by disrupting inhibitory tropomysin positioning -ADAM17 TACE EC 3.4.24.86; Membrane protein, integral; Motility/polarity/chemotaxis; Protease P78536 6868 2p25.1 human T735-p 449804 KPFPAPQtPGRLQPA activity, induced; intracellular localization; enzymatic activity, induced cell cycle regulation; carcinogenesis, induced; apoptosis, induced; cell growth, induced; apoptosis, inhibited 12058067; 20188673; 21586567; 23955714; 34743207; 37046278 18 15 6 -Calm1 Calmodulin Calcium-binding; Protein phosphatase, regulatory subunit P0DP29 24242 6q32 rat T45-p 469598 RSLGQNPtEAELQDM EF-hand_7 molecular association, regulation CAMK2A(NOT_REPORTED) 12392717 1 0 0 no effects on CaM-kinase I and IV or CaM-kinase kinase alpha activity. ; non-phosphorylated calmodulin activates CaM-kinase II more than calmodulin phosphorylated on T44 by CaM-kinase IV -TOPBP1 TOPBP1 DNA replication Q92547 11073 3q22.1 human S1159-p 472408 EERARLAsNLQWPSC molecular association, regulation; protein conformation; phosphorylation cell cycle regulation; transcription, induced; transcription, inhibited TOPBP1(INDUCES); ATR(DISRUPTS); E2F1(INDUCES) DNA(DISRUPTS) 17913746; 19477925; 24081328 4 0 11 Phosphorylation and oligomerization induce enhancement of Ets-1 transcription and cooperation with TCF20.; inhibits Chk1 phosphorylation -DNAJB2 DNAJB2 Chaperone P25686 3300 2q35 human S250-p 34499810 CPLDSDLsEDEDLQL molecular association, regulation 28031292 1 4 0 phosphorylation reduced its ability to bind ubiquitylated clients, and chaperone activity -Rela NFkB-p65 DNA-binding; Nuclear receptor co-regulator; Transcription factor Q7TQN4 309165 1q43 rat S535-p 447800 SGDEDFSsIADMDFS autophagy, induced; apoptosis, induced; apoptosis, inhibited; transcription, induced; signaling pathway regulation 21550382; 21904602; 33520106; 35917315; 37237886 254 4 0 -CARHSP1 CARHSP1 RNA-binding Q9Y2V2 23589 16p13.2 human S41-p 455702 LRGNVVPsPLPTRRT molecular association, regulation; intracellular localization DNA(DISRUPTS) 21177848 3 99 187 phosphomimetic S41D mutation abolishes the ssDNA binding in vitro and releases CaRHSP1 from stress granules -GAB2 GAB2 Adaptor/scaffold Q9UQC2 9846 11q14.1 human Y614-p 449788 KSTGSVDyLALDFQP molecular association, regulation; phosphorylation cell cycle regulation; transcription, altered SHP-2(NOT_REPORTED); SHP-2(INDUCES) 11334882; 11572860; 15170389; 18644434; 23980151 6 8 55 Binding of SHP-2 activates the MAPK pathway and transcription. -H4c2 H4 DNA-binding P62806 326620 13|13 A3.1 mouse K16-ac 458960 GLGKGGAkRHRKVLR protein degradation cell cycle regulation; chromatin organization, altered; apoptosis, induced; transcription, induced; transcription, altered 17344422; 17530637; 17823087; 20710121; 23394119; 23468428; 25519132; 31437213 106 26 531 Arrested round spermatids containing PSMA8 are involved in acetyation-dependent degradation of histones during prophase I. -CTNND1 CTNND1 Actin-binding; Adaptor/scaffold; Cell adhesion; G protein regulator, misc.; Motility/polarity/chemotaxis O60716 1500 11q12.1 human S288-p 450452 GLEDDQRsMGYDDLD carcinogenesis, induced; cell motility, induced; cell adhesion, inhibited 32589661 7 35 27 -RELA NFkB-p65 DNA-binding; Nuclear receptor co-regulator; Transcription factor Q04206 5970 11q13.1 human T254-p 450278 QVAIVFRtPPYADPS RHD_dimer activity, induced; protein stabilization; molecular association, regulation; intracellular localization transcription, induced; signaling pathway regulation; transcription, altered PIN1(INDUCES) 14690596; 26729520; 34034759; 35487976 5 0 1 -SPIN1 SPIN1 DNA-binding; Nucleolus Q9Y657 10927 9q22.1 human S124-p 3217695 RVATSRIsDAHLADT molecular association, regulation carcinogenesis, induced; cell growth, induced; transcription, induced; signaling pathway regulation TCF4(INDUCES) 22258766 1 21 1 induces WNT/TCF signaling -Lat2 LAB Adaptor/scaffold; Membrane protein, integral Q9JHL0 56743 5|5 G2 mouse Y121-p 454709 VDPIPTNyYNWGCFQ LAT2 signaling pathway regulation 22308309 2 1 19 plays a negative role in TCR and FcRI-mediated and no role in LPS-mediated signaling -E2F1 E2F1 DNA-binding; Transcription factor Q01094 1869 20q11.22 human S31-p 447867 ALRLLDSsQIVIISA protein stabilization apoptosis, induced; transcription, induced 11459832; 22184068 3 0 0 etoposide-induced DNA damage, pRB-free form of E2F1, does not bind to pRB; both complexes act in parallel to induce transcription of proapoptotic genes -CHEK2 Chk2 EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, CAMK; Protein kinase, Ser/Thr (non-receptor); Tumor suppressor O96017 11200 22q12.1 human S33-p 447549 TQSQGSSsQSQGISS molecular association, regulation; enzymatic activity, induced cell cycle regulation Chk2(INDUCES); PPP2CA(DISRUPTS) 16940182; 20160490 11 1 0 S19A mutant shows impaired dimerization and does not promote Hdmx degradation -RBBP8 CtIP EC 3.1.-.-; Transcription, coactivator/corepressor Q99708 5932 18q11.2 human S276-p 28058803 SETQGPMsPLGDELY protein degradation; molecular association, regulation; ubiquitination; protein conformation; enzymatic activity, induced; phosphorylation DNA repair, altered PIN1(INDUCES) 23623683; 24837676 2 1 0 inhibits phosphorylation of RPA2 -PPARA PPAR-alpha DNA-binding; Nuclear receptor; UBIQUITIN LIGASE Q07869 5465 22q13.31 human S230-p 2902207 VKARVILsGKASNNP transcription, altered 15131257 1 0 0 -Cd1d1 CD1D Apoptosis; Cell surface; Lipid-binding; Membrane protein, integral P11609 12479 3 F1|3 37.91 cM mouse Y332-p 1414324300 IWRRRSAyQDIR___ molecular association, regulation Pyk2(INDUCES) 30514903 1 0 0 -CABLES1 CABLES1 Adaptor/scaffold Q8TDN4 91768 18q11.2 human T415-p 3207279 AFGARRNtIDSTSSF molecular association, regulation; phosphorylation; enzymatic activity, induced carcinogenesis, induced; apoptosis, inhibited; transcription, altered 14-3-3 gamma(INDUCES); CDK2(DISRUPTS) 25361894 1 22 74 inhibits phosphorylation of Cdk2 and increases its kinase activity, decreaes p21 and increases phosphorylated Rb protein levels -ULK1 ULK1 Autophagy; EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, Other; Protein kinase, Ser/Thr (non-receptor) O75385 8408 12q24.33 human S758-p 483139 PVVFTVGsPPSGSTP molecular association, regulation; enzymatic activity, inhibited; phosphorylation carcinogenesis, induced; carcinogenesis, inhibited; apoptosis, induced; cell growth, inhibited; signaling pathway regulation; transcription, altered; autophagy, induced; cell growth, induced; autophagy, altered; autophagy, inhibited AMPKA1(INDUCES) 21383122; 24998849; 26687599; 30021155; 30093610; 32134989; 34336098; 34482636; 34546793; 34604061; 34624079; 34673774; 34759263; 34820368; 35017646; 35368866; 35443161; 36008391; 36476874 78 15 2 -DUSP16 DUSP16 EC 3.1.3.16; EC 3.1.3.48; PHOSPHATASE; Protein phosphatase, dual-specificity Q9BY84 80824 12p13.2 human S446-p 449606 TNKLCQFsPVQELSE protein stabilization 15689616 2 3 0 -ESR1 ER-alpha DNA-binding; Nuclear receptor; Transcription factor P03372 2099 6q25.1-q25.2 human T594-p 28070700 EAEGFPAtV______ ESR1_C molecular association, regulation transcription, altered; cell growth, altered 14-3-3 beta(INDUCES); 14-3-3 sigma(INDUCES); 14-3-3 zeta(INDUCES); 14-3-3 epsilon(INDUCES); 14-3-3 gamma(INDUCES); 14-3-3 eta(INDUCES); ER-alpha(INDUCES) 23676274 1 1 0 interaction with 14-3-3 protein has a negative effect on receptor dimerization; receptor dimerization -SRF SRF Motility/polarity/chemotaxis; Transcription factor P11831 6722 6p21.1 human T159-p 449631 DNKLRRYtTFSKRKT SRF-TF activity, induced transcription, induced; transcription, inhibited 12809504; 19778940 2 0 0 -PDPK1 PDK1 EC 2.7.11.1; KINASE; Kinase, protein; Nuclear receptor co-regulator; Protein kinase, AGC; Protein kinase, Ser/Thr (non-receptor) O15530 5170 16p13.3 human S64-p 27457101 EPRPGAGsLQHAQPP protein stabilization 28152304 1 2 0 T cell activation, IL-2 production, enhances TCR/CD28 mediated NF-KB activit -Mecp2 MECP2 Transcription, coactivator/corepressor Q9Z2D6 17257 X A7.3|X 37.63 cM mouse T308-p 28699600 LPIKKRKtRETVSIE molecular association, regulation; activity, inhibited transcription, induced N-CoR1(DISRUPTS) DNA(INDUCES) 23770587 2 0 0 -COIL coilin Oxidoreductase P38432 8161 17q22 human S272-p 6421922 TLEARNSsEKLPTEL cell growth, inhibited 21991343 1 8 0 Cajal body formation, phosphomutant cell lines show a significant reduction in CB formation compared to wild-type after endogenous coilin knockdown -Scimp UNQ5783 Membrane protein, integral Q3UU41 327957 11|11 B3 mouse Y58-p 3975471 GRDEEKMyENVLNSS SCIMP molecular association, regulation transcription, induced GRB2(INDUCES); TLR4(INDUCES); CSK(INDUCES); TLR2(INDUCES); BLNK(INDUCES); TLR1(INDUCES); TLR3(INDUCES) 34496234; 35337798 2 1 1 -Cd3e CD3E Membrane protein, integral; Receptor, misc. P22646 12501 9 A5.2|9 24.84 cM mouse Y170-p 448918 PPVPNPDyEPIRKGQ ITAM molecular association, regulation PIK3R1(INDUCES) 9312149 5 12 382 -DRD3 DRD3 GPCR, family 1; Membrane protein, integral; Membrane protein, multi-pass; Receptor, GPCR P35462 1814 3q13.31 human S229-p 482885 RILTRQNsQCNSVRP 7tm_1 receptor desensitization, altered; receptor internalization, altered 17536008 2 0 0 -Gorasp1 GRASP65 Vesicle O35254 56082 8q32 rat T220-p 4768150 PSASSPGtPAKTPQP intracellular localization cell cycle regulation 23259055 1 7 0 Regulation of mitotic golgi disassembly and reassembly; inactivation of T220/T224, and eventually S277partial dephosphorylation -ADRA1D ADRA1D GPCR, family 1; Membrane protein, integral; Membrane protein, multi-pass; Receptor, GPCR P25100 146 20p13 human S331-p 1424270004 AKGHTFRsSLSVRLL 7tm_1 receptor internalization, altered signaling pathway regulation 29551601 1 1 0 regulates ERK signaling pathway, induces calcium signaling de-sensitization -BLNK BLNK Adaptor/scaffold Q9YGC1 395733 chicken S173-p 1868112506 PKKPSLPsPAAKPKL phosphorylation transcription, altered 19372136 1 1 0 -PDGFRB PDGFRB EC 2.7.10.1; KINASE; Kinase, protein; Membrane protein, integral; Oncoprotein; Protein kinase, TK; Protein kinase, tyrosine (receptor) P09619 5159 5q32 human Y1009-p 447522 LDTSSVLyTAVQPNE activity, induced; molecular association, regulation; phosphorylation cell growth, altered SH3KBP1(INDUCES); PLCG1(INDUCES); SHP-2(INDUCES); PIK3R1(DISRUPTS); RASA1(DISRUPTS); CBL(INDUCES) 10391677; 11864611; 11896619; 12177062; 1396585; 17403678; 7545675; 7935391; 9673410 17 0 0 Stimulation with EGF or PDGF SH3SKP1 induced minimal increase in association. Association is constitutive in tumor cell lines.; Y1009 and Y1021 phosphorylation mediates PDGFBB and thrombin induced calcium signaling. -TP53BP1 53BP1 DNA repair, damage; Transcription, coactivator/corepressor Q12888 7158 15q15.3 human S1317-p 476252 SSLHRTSsGTSLSAM molecular association, regulation; intracellular localization; phosphorylation DNA repair, induced; apoptosis, inhibited H4(INDUCES) 33596428 1 19 21 regulates phosphorylation of CHK2, ATM, DNA-PK -HDAC4 HDAC4 DEACETYLASE; Deacetylase; EC 3.5.1.98; Hydrolase; Nuclear receptor co-regulator; SUMO LIGASE P56524 9759 2q37.3 human S210-p 2631600 YGKTQHSsLDQSSPP transcription, altered 17179159 1 4 0 -CTNNB1 CTNNB1 Actin-binding; Cell adhesion; Motility/polarity/chemotaxis; Nuclear receptor co-regulator; Oncoprotein; Transcription factor P35222 1499 3p22.1 human Y142-p 449044 AVVNLINyQDDAELA protein degradation; molecular association, regulation; intracellular localization carcinogenesis, induced; cell growth, induced; apoptosis, inhibited; transcription, induced; cytoskeletal reorganization; signaling pathway regulation Bcl-9L(INDUCES); CTNNA1(DISRUPTS); CTNNA1(INDUCES) 15371335; 22558232; 24240237; 30747223; 34227224 16 2 0 TCF/LEF pathway -APLNR APLNR GPCR, family 1; Membrane protein, integral; Membrane protein, multi-pass; Receptor, GPCR P35414 187 11q12.1 human S348-p 36436800 EKSASYSsGHSQGPG receptor internalization, induced; receptor desensitization, induced; molecular association, regulation; phosphorylation GRK5(INDUCES); ARRB1(INDUCES); GRK2(INDUCES); ARRB2(INDUCES) 25271156 1 2 0 enhanced ERK1/2 phosphorylation -KMT5A SETD8 Amino Acid Metabolism - lysine degradation; EC 2.1.1.43; METHYLTRANSFERASE; Methyltransferase; Methyltransferase, protein lysine Q9NQR1 387893 12q24.31 human K151-sm 25090303 NAVRSAMkSEEQKIK transcription, inhibited 21829513 1 0 0 -Hnrnpf hnRNP F RNA splicing; RNA-binding; Spliceosome Q794E4 64200 4q42 rat K224-ac 11320524 RRYIGIVkQAGLDRM protein stabilization RNA splicing, induced 25959059 1 2 3 -KCNK18 KCNK18 Channel, ligand-gated; Channel, potassium; Membrane protein, integral; Membrane protein, multi-pass Q7Z418 338567 10q25.3 human S264-p 12525800 VLGRLSYsIISNLDE intracellular localization; activity, inhibited transcription, inhibited 25202008; 30327410; 30992311 8 0 0 -GLRB GLRB Channel, ligand-gated; Membrane protein, integral; Membrane protein, multi-pass; Transporter; Transporter, ion channel P48167 2743 4q32.1 human Y435-p 3078004 RDFELSNyDCYGKPI Neur_chan_memb activity, induced 11882681 1 0 0 -TRPV5 TRPV5 Channel, cation; Membrane protein, integral; Membrane protein, multi-pass; Motility/polarity/chemotaxis Q9NQA5 56302 7q34 human S299-p 470108 FLELVVSsDKREARQ activity, induced; intracellular localization 17006539 3 0 0 -WTAP WTAP Nucleolus; Spliceosome Q15007 9589 6q25.3 human S306-p 453808 TEDDFPSsPGNGNKS cell differentiation, induced 33217317 1 37 127 -RGS4 RGS4 GAP; GAP, RGS Q0R4E4 100009014 rabbit S52-p 469585 VVVCQRVsQEEVKKW molecular association, regulation; intracellular localization G-alpha(q)(INDUCES) 16885398 1 0 0 -IRF3 IRF3 DNA-binding; Transcription factor Q14653 3661 19q13.33 human T404-p 449031 NSHPLSLtSDQYKAY activity, induced; protein degradation; molecular association, regulation; intracellular localization; protein conformation; phosphorylation autophagy, induced; transcription, induced; transcription, altered CALCOCO2(INDUCES); CBP(INDUCES) 17526488; 18272581; 19153595; 25070846; 27992402; 37330913; 9566918 9 2 0 GPR108 and Smurf1 mediated degradation requires NDP52; NDP52-dependent autophagic degradation of phosphorylated IRF3; GPR108 interacts with Smurf1, followed by the recruitment of IRF3 during viral infection -Cacna1b CACNA1B Channel, calcium; Membrane protein, integral; Membrane protein, multi-pass Q02294 257648 3p13 rat S2126-p 467286 SEKQRFYsCDRFGSR molecular association, regulation 14-3-3 gamma(INDUCES) 16982421 1 1 0 -AICDA AID EC 3.5.4.38; Hydrolase Q9GZX7 57379 12p13.31 human S3-p 20660600 _____MDsLLMNRRK protein degradation cell cycle regulation 26355458 2 0 0 -TOP1 TOP1 EC 5.99.1.2; Isomerase; Nucleolus; Oncoprotein P11387 7150 20q12 human S506-p 27276101 ADTVGCCsLRVEHIN Topoisom_I molecular association, regulation ARF1(INDUCES) DNA(INDUCES) 23185622; 23555599 3 0 0 ARF enhances the binding of hyperphosphorylated S506 to DNA. ; enhances relaxation of supercoiled DNA by increasing TOP1 DNA binding -DEK DEK DNA replication; DNA-binding; Histone-binding; Oncoprotein; RNA splicing P35659 7913 6p22.3 human T67-p 27777400 KKKVERLtMQVSSLQ protein degradation; molecular association, regulation RNA splicing, induced FBXW7(INDUCES) 21282377 2 2 0 regulates tropomyosin alternative splicing -Pten PTEN Carbohydrate Metabolism - inositol phosphate; EC 3.1.3.16; EC 3.1.3.48; EC 3.1.3.67; Motility/polarity/chemotaxis; Nuclear receptor co-regulator; PHOSPHATASE; Phosphatase, lipid; Tumor suppressor O08586 19211 19 C1|19 28.14 cM mouse T382-p 448314 DHYRYSDtTDSDPEN enzymatic activity, inhibited 24367090 22 2 0 -TTK TTK Cancer Testis Antigen (CTA); EC 2.7.12.1; KINASE; Kinase, protein; Protein kinase, Other; Protein kinase, dual-specificity (non-receptor) P33981 7272 6q14.1 human T468-p 471488 DYMSCFRtPVVKNDF activity, induced; molecular association, regulation; protein stabilization cell cycle regulation CDKN3(INDUCES) 17804818; 26586430 2 2 2 regulates centrosomes duplication and a cell cycle; regulates TTK stability and as a result its accumulation at centrosomes; recruiting Cdkn3 to centrosomes, interaction is required for maintaining the proper number of centrosomes -Npm1 NPM1 Nucleolus; Oncoprotein; RNA-binding; Translation Q61937 18148 11|11 A4 mouse T198-p 448515 VKKSVRDtPAKNAQK molecular association, regulation; intracellular localization cell cycle regulation; RNA splicing, altered; cytoskeletal reorganization ROCK2(INDUCES) RNA(INDUCES) 16376875; 17015463; 19933848 24 29 30 centrosome duplication -Wasl N-WASP Adaptor/scaffold; Motility/polarity/chemotaxis O08816 682507 4q22 rat S239-p 457322 LFDMCGIsEAQLKDR PBD cytoskeletal reorganization 16257963 1 0 0 phosphorylation of this site plays a role in regulation of actin polymerization -TGFBR3 TGFBR3 Membrane protein, integral Q03167 7049 1p22.1 human T843-p 455562 SIGSTQStPCSSSST molecular association, regulation; receptor internalization, altered; intracellular localization ARRB1(INDUCES) 12958365 1 0 0 -Map3k7 TAK1 EC 2.7.11.25; KINASE; Kinase, protein; Protein kinase, Ser/Thr (non-receptor); Protein kinase, TKL Q62073 26409 4|4 A5 mouse T187-p 454704 CDIQTHMtNNKGSAA PK_Tyr_Ser-Thr phosphorylation carcinogenesis, induced; transcription, induced; signaling pathway regulation 27542620; 35051616 33 1 0 -IRAK1 IRAK1 EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, Ser/Thr (non-receptor); Protein kinase, TKL P51617 3654 Xq28 human S375-p 31085747 AGSSPSQsSMVARTQ Pkinase enzymatic activity, induced 29208712 0 2 0 -JADE1 JADE1 Tumor suppressor Q6IE81 79960 4q28.2 human S18-p 35530402 EDSDDNGsLSTTWSQ EPL1 protein stabilization; activity, inhibited cell differentiation, induced; transcription, induced; signaling pathway regulation 25100726 1 1 0 impairs the ability of Jade-1S to inhibit Wnt reporter activity; Decrease the ability of Jade-1 to inhibit ?-catenin signaling -RNF146 RNF146 EC 6.3.2.-; EC 6.3.2.19; UBIQUITIN LIGASE; Ubiquitin conjugating system; Ubiquitin ligase Q9NTX7 81847 6q22.33 human K176-sm 1883827102 DIIDIPKkGVAGLRL protein degradation cell growth, induced 37029301 1 0 0 degradation of Axin and upregulation of ?-catenin, progression of HCC cells, abolishing RNF146 SUMOylation inhibits HCC cell tumorigenesis -STMN1 STMN1 Cytoskeletal P16949 3925 1p36.11 human K9-ac 3856124 ASSDIQVkELEKRAS Stathmin protein stabilization; phosphorylation TUBA1A(INDUCES); RNF12(DISRUPTS) 35581193 1 2 1 K9 acetylation inhibits S25 phosphorylation, induces interaction with tubulin and inhibits interaction with RNF12. -Nrip1 RIP140 Nuclear receptor co-regulator; Transcription, coactivator/corepressor Q8CBD1 268903 16|16 C3.1 mouse K287-ac 459036 YSREHALkTQNAHQV NRIP1_repr_1 activity, induced; intracellular localization transcription, inhibited 15879431; 18655826 1 2 0 enhanced fat accumulation in differentiated adipocytes -NTRK3 TrkC EC 2.7.10.1; KINASE; Kinase, protein; Membrane protein, integral; Protein kinase, TK; Protein kinase, tyrosine (receptor) Q16288 4916 15q25.3 human Y709-p 464877 RDVYSTDyYRLFNPS PK_Tyr_Ser-Thr carcinogenesis, induced; signaling pathway regulation 10702799 1 1 29 -Mafa MAFA DNA-binding; Oncoprotein; Transcription factor; Tumor suppressor Q8CF90 378435 15|15 D3 mouse T53-p 1320402 PPGSLSStPLSTPCS protein degradation; molecular association, regulation transcription, inhibited MAFA(INDUCES); PSME3(INDUCES) DNA(NOT_REPORTED) 20208071; 21646385 4 1 0 -CTPS2 CTPS2 EC 6.3.4.2; Ligase; Nucleotide Metabolism - pyrimidine Q9NRF8 56474 Xp22.2 human S568-p 3213615 LSSSDRYsDASDDSF enzymatic activity, inhibited 20739275 1 41 5 -TBK1 TBK1 EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, Other; Protein kinase, Ser/Thr (non-receptor) Q9UHD2 29110 12q14.2 human R134-me 1881361502 RENGIVHrDIKPGNI enzymatic activity, induced 34551290 1 0 0 TBK1 aggregation, PRMT1 positively regulates antiviral immune responses, and promotes cellular innate antiviral signaling -Stmn1 STMN1 Cytoskeletal P13668 29332 5q36 rat S63-p 448557 AAEERRKsHEAEVLK Stathmin cytoskeletal reorganization 24302736; 31933182 26 56 32 increase microtubule depolymerization; Regulates tubulin polymerization -CDCA5 CDCA5 Cell cycle regulation Q96FF9 113130 11q13.1 human T111-p 469415 KTHSVPAtPTSTPVP Sororin molecular association, regulation; activity, inhibited cell cycle regulation SCC-112(DISRUPTS); H2A.1(DISRUPTS); SMC3(DISRUPTS) 21878504; 23901111 2 6 15 -NCAM1 NCAM1 iso1 Cell adhesion; Membrane protein, GPI anchor; Membrane protein, integral; Motility/polarity/chemotaxis P13591-1 4684 11q23.2 human T803-p 15721468 HTEPNETtPLTEPEK endocytosis, induced; cell growth, inhibited 28193531 1 2 0 shorter neurite outgrowth -Nfya NFYA DNA-binding; Transcription factor P23708 18044 17 C|17 23.99 cM mouse K283-ub 4664704 KRRQARAkLEAEGKI CBFB_NFYA protein degradation cell growth, inhibited; transcription, inhibited 18815279 1 0 0 -CD28 CD28 Cell surface; Membrane protein, integral P10747 940 2q33.2 human Y206-p 450283 PGPTRKHyQPYAPPR phosphorylation carcinogenesis, inhibited; cell growth, inhibited; signaling pathway regulation 20368329; 30131370 3 3 168 -STAT6 STAT6 DNA-binding; Transcription factor P42226 6778 12q13.3 human S707-p 17772900 IPPYQGLsPEESVNV STAT6_C molecular association, regulation transcription, inhibited DNA(NOT_REPORTED) 21123173 1 0 0 suppresses transcriptional activity of STAT6 -SMPD3 SMPD3 EC 3.1.4.12; Lipid Metabolism - sphingolipid; Membrane protein, integral; Phospholipase Q9NY59 55512 16q22.1 human K103-ub 1880099300 IYSRLEDkGLAGGAA protein degradation 36261549 1 0 0 -RPL11 RPL11 Motility/polarity/chemotaxis; Nucleolus; Ribosomal; Translation P62913 6135 1p36.11 human K88-ne 12067609 EILEKGLkVREYELR Ribosomal_L5_C protein stabilization; intracellular localization 19713960 1 0 0 -GPR3 GPR3 Cell cycle regulation; GPCR, family 1; Membrane protein, integral; Membrane protein, multi-pass; Receptor, GPCR P46089 2827 1p36.11 human S237-p 29649502 QRHLLPAsHYVATRK 7tm_1 molecular association, regulation; intracellular localization ARRB1(DISRUPTS); APP(DISRUPTS) 24069330 1 0 0 237A mutant stimulates production of beta-amyloid and shows enhanced GPR3 clustering. ; colocalization with Amyloid Precursor Protein -MRE11 MRE11A Cell cycle regulation; DNA repair, damage; DNA-binding; Deoxyribonuclease P49959 4361 11q21 human R576-me 2344813 GRGRGRGrRGGRGQN intracellular localization 15970667 1 0 0 localizes in nucleus and associates with nuclear bodies and sites of DNA damage -UBAP2L NICE-4 RNA-binding; Ubiquitin conjugating system Q14157 9898 1q21.3 human R190-m2 27280776 GSGRRGGrFSAQGMG molecular association, regulation 31114027 1 3 1 regulation of stress-granule dynamics by NICE-4 arginine methylation -DAXX DAXX Apoptosis; Nuclear receptor co-regulator; Nucleolus; Transcription, coactivator/corepressor Q9UER7 1616 6p21.32 human K631-sm 2407411 DSGPPCKkSRKEKKQ molecular association, regulation; intracellular localization cell growth, inhibited; transcription, inhibited PML(INDUCES) 16818774 4 0 0 -Pkm PKM Carbohydrate Metabolism - glycolysis and gluconeogenesis; Carbohydrate Metabolism - pyruvate; EC 2.7.1.40; KINASE; Kinase, other; Mitochondrial; Nucleotide Metabolism - purine P52480 18746 9 B|9 32.03 cM mouse S37-p 476070 MCRLDIDsAPITARN intracellular localization apoptosis, induced 35637461; 36322626; 37126714 17 62 6 -Dpysl5 CRMP-5 Q9EQF6 65254 5|5 B1 mouse T514-p 478231 MGTPLADtPTRPVTR phosphorylation 29758318 1 8 2 S522A KI mice -Irs2 IRS2 Adaptor/scaffold; Motility/polarity/chemotaxis P81122 384783 8 A1.1|8 5.35 cM mouse Y911-p 3217416 EPKSPGEyINIDFGE signaling pathway regulation 23775122 2 3 2 -SMAD1 SMAD1 DNA-binding; Transcription factor Q15797 4086 4q31.21 human T322-p 25802105 SNVNRNStIENTRRH MH2 activity, inhibited; phosphorylation 21690388 2 4 0 phosphorylation of the site inhibits phosphorylation of the C-terminal domain of SMAD1. -SMAD3 SMAD3 DNA-binding; Nuclear receptor co-regulator; Transcription factor P84022 4088 15q22.33 human S264-p 1868957100 VDGFTDPsNSERFCL MH2 protein stabilization; activity, inhibited; phosphorylation cell differentiation, inhibited; cell growth, induced; transcription, inhibited; signaling pathway regulation 32232430 1 0 0 inhibits self phosphorylation and TGFB/SMAD pathway -Fcor FcoR P0DJI6 100503924 8|8 A1.1 mouse T93-p 25244200 DLNSQRStCCCLLNA acetylation; intracellular localization transcription, inhibited 22510882 1 0 0 suppresses expression of PGC-1alpha; increases FoxoO1 acetylation and inhibits its transcriptional activity -DAB1 DAB1 Adaptor/scaffold Q8JH94 374083 chicken Y198-p 447629 EDVEDPVyQYIVFEA phosphorylation cytoskeletal reorganization 15057276 11 1 0 increases Src activation and overall tyrosine phosphorylation levels in the cell, alters cellular morphology -MLKL MLKL KINASE; Kinase, protein; Protein kinase, Ser/Thr (non-receptor); Protein kinase, TKL Q8NB16 197259 16q23.1 human Y376-p 1868624704 DRVKSTAyLSPQELE PK_Tyr_Ser-Thr protein stabilization; molecular association, regulation MLKL(INDUCES) 31230815 1 1 0 promotes necroptosis -NFATC1 NFAT2 DNA-binding; Transcription factor O95644 4772 18q23 human S245-p 448861 PSTSPRAsVTEESWL activity, induced; intracellular localization; activity, inhibited; phosphorylation carcinogenesis, induced; cell motility, induced; transcription, induced 12351631; 31730483; 9072970 3 7 1 phosphorylation creates predicted overlapping GSK3B phosphorylation sites; multiple sites mutatnt -PLD1 PLD1 iso2 EC 3.1.4.4; Lipid Metabolism - ether lipid; Lipid Metabolism - glycerophospholipid; Motility/polarity/chemotaxis; Phospholipase Q13393-2 5337 3q26.31 human S2-p 448572 ______MsLKNEPRV intracellular localization; enzymatic activity, induced 16978840 4 2 0 -XRCC5 Ku80 DNA-binding; EC 3.6.1.-; EC 3.6.4.-; Helicase; Nuclear receptor co-regulator; Nucleolus; RNA-binding P13010 7520 2q35 human K195-ub 10835386 HGPSFPLkGITEQQK Ku_N molecular association, regulation DNA repair, induced DNA(DISRUPTS) 27895153 1 9 86 -DAB2IP DAB2IP iso2 GAP; GAP, Ras; Tumor suppressor Q5VWQ8-2 153090 9q33.2 human T546-p 3958578 GTNDLAStPGSGSSS DUF3498 ubiquitination; phosphorylation cell cycle regulation; carcinogenesis, inhibited; chromatin organization, altered; cytoskeletal reorganization PLK1(INDUCES) 34775484 1 1 2 inhibitrs CDC20 ubiquitination, induces PLK1, TTK phosphorylation -GAPDH GAPDH Carbohydrate Metabolism - glycolysis and gluconeogenesis; EC 1.2.1.12; Oxidoreductase P04406 2597 12p13.31 human K227-ac 461582 VIPELNGkLTGMAFR Gp_dh_C intracellular localization 20601085 1 6 22 nuclear translocation -Atp1b1 ATP1B1 Membrane protein, integral; Transporter P07340 25650 13q23 rat S11-p 29573988 GKAKEEGsWKKFIWN Na_K-ATPase protein degradation; molecular association, regulation; ubiquitination endocytosis, induced TRAF2(INDUCES) 34277634 1 2 0 -TET1 TET1 DNA-binding; EC 1.14.11.n2; Oxidoreductase Q8NFU7 80312 10q21.3 human K1589-ub 38497600 SMYFNGCkFGRSPSP Tet_JBP intracellular localization; enzymatic activity, induced 25557551 1 0 0 -Flcn FLCN Tumor suppressor Q76JQ2 303185 10q22 rat S302-p 3206871 ESESWDNsEAEEEEK molecular association, regulation AMPKA1(DISRUPTS) 19695222 1 16 0 -JUN Jun Oncoprotein; Transcription factor P05412 3725 1p32.1 human T2-p 17737603 ______MtAKMETTF carcinogenesis, altered; cell growth, altered 21177766 1 0 0 -Nr2e3 NR2E3 Nuclear receptor Q9QXZ7 23958 9 B|9 32.35 cM mouse K315-sm 7324002 LKALVLFkPETRGLK Hormone_recep transcription, inhibited 19186166 1 0 0 -Optn optineurin Inhibitor Q8K3K8 71648 2 A1|2 3.15 cM mouse S517-p 21214714 EEGGSRQsLMEMQCR autophagy, induced 33931895 4 5 0 regulates mitochondrial homeostasis and pluripotency -Ldb3 LDB3 Cytoskeletal Q9JKS4 24131 14|14 B mouse S265-p 10364530 DEWARRSsNLQSRSF DUF4749 phosphorylation cytoskeletal reorganization; signaling pathway regulation 23996002 1 1 2 facilitated PKA-mediated phosphorylation, sarcomere signaling center -AQP9 AQP9 Channel, misc.; Membrane protein, integral; Membrane protein, multi-pass; Transporter; Transporter, aquaporin family O43315 366 15q21.3 human S222-p 477184 MNPARDLsPRLFTAL MIP cytoskeletal reorganization 17346701; 28419510 2 1 0 mutation decreases sensitivity to hypo-osmolar conditions and formation of filopodia; ?lopodia formation -TRAF3 TRAF3 UBIQUITIN LIGASE; Ubiquitin conjugating system; Ubiquitin ligase Q13114 7187 14q32.32 human S349-p 8098598 QNWEEADsMKSSVES molecular association, regulation; ubiquitination transcription, induced TBK1(INDUCES) 26928339 1 2 1 virus-induced production of type I interferons, TRAF3-TBK1?induced luciferase activity of the IFN-? reporter -SHC1 SHC1 Adaptor/scaffold; Apoptosis; Mitochondrial; Motility/polarity/chemotaxis P29353 6464 1q21.3 human T386-p 457351 PTAPNAQtPSHLGAT protein stabilization apoptosis, induced 16251354 1 1 1 Phosphorylation necessary to promote activated-Rac1-induced oxidative stress (ROS-induced apoptosis). -CCR5 CCR5 GPCR, family 1; Membrane protein, integral; Membrane protein, multi-pass; Motility/polarity/chemotaxis; Receptor, GPCR; Receptor, cytokine P51681 1234 3p21.31 human S337-p 448725 EAPERASsVYTRSTG molecular association, regulation; receptor desensitization, altered; receptor internalization, altered ARRB1(INDUCES); ARRB2(INDUCES) 10085131; 11782464; 12065593 3 0 0 -Hnrnpk hnRNP K RNA splicing; RNA-binding; Spliceosome P61979 15387 13|13 B1 mouse S116-p 452369 EEGLQLPsPTATSQL intracellular localization 20960454 4 38 22 -Adcy6 ADCY6 Adenylyl cyclase; EC 4.6.1.1; Lyase; Membrane protein, integral; Membrane protein, multi-pass; Nucleotide Metabolism - purine; Transporter; Transporter, aquaporin family AAA40678 25289 7q36 rat S746-p 467273 ALQRLSRsIVRSRVH enzymatic activity, induced 11327830; 15470083 2 0 0 increases potentiation -PRKN PARK2 EC 6.3.2.-; EC 6.3.2.19; Ligase; Translation; Translation regulation; UBIQUITIN LIGASE; Ubiquitin conjugating system; Ubiquitin ligase O60260 5071 6q26 human K220-ub 1881186502 GAHPTSDkETSVALH protein degradation; ubiquitination 33565245 1 0 0 -NDUFA12 NDUFA12 EC 1.6.5.3; EC 1.6.99.3; Mitochondrial; Oxidoreductase Q9UI09 55967 12q22 human T120-p 33402205 HKFNVTGtPEQYVPY NDUFA12 activity, induced cell cycle regulation 24746669 1 2 0 increases mitochondrial respiration for G/2M transition -ULK1 ULK1 Autophagy; EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, Other; Protein kinase, Ser/Thr (non-receptor) O75385 8408 12q24.33 human S469-p 483137 IRRSGSTsPLGFARA protein degradation; molecular association, regulation; ubiquitination; enzymatic activity, inhibited cell growth, induced; apoptosis, inhibited; autophagy, inhibited ATG13(DISRUPTS); ATG101(DISRUPTS); RB1CC1(DISRUPTS) 31378785 1 31 7 regulates resistance of gliomas to TMZ -ARRB2 ARRB2 iso2 Adaptor/scaffold P32120-2 281638 cow K397-sm 25350105 DFARLRLkGLKDEDY molecular association, regulation AP-2 beta(INDUCES) 21118812 1 0 0 GPCR endocytosis induced -HSF4 HSF4 Cell development/differentiation; DNA-binding; Transcription, coactivator/corepressor Q9ULV5 3299 16q22.1 human T471-p 30318200 LGLPGALtIYSTPES protein stabilization; ubiquitination; intracellular localization transcription, induced KPNB1(DISRUPTS) 24361130 1 1 0 upregulation of alpha-beta-crystaline and Hsp25, nuclear localization, T471A mutant promotes degradation via ubiquitin-proteasome. -DAPK2 DAPK2 EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, CAMK; Protein kinase, Ser/Thr (non-receptor) Q9UIK4 23604 15q22.31 human S318-p 450028 VRRRWKLsFSIVSLC molecular association, regulation apoptosis, altered; apoptosis, inhibited DAPK2(DISRUPTS); CAMK1A(DISRUPTS); Calmodulin(DISRUPTS) 11230133; 34413451 2 4 0 -Scn5a SCN5A Channel, sodium; Membrane protein, integral; Membrane protein, multi-pass Q9JJV9 20271 9 F3|9 71.33 cM mouse K1481-ac 63044906 NFNQQKKkLGGQDIF Ion_trans intracellular localization 28191886 3 2 0 -Nos1 nNOS Amino Acid Metabolism - arginine and proline; EC 1.14.13.39; Oxidoreductase P29476 24598 12q16 rat K1371-ac 2459111 RIMTQQGkLSEEDAG activity, induced 18415985 1 0 0 -Elk1 ELK1 DNA-binding; Transcription factor P41969 13712 X A1.3|X 16.45 cM mouse T337-p 2751400 GGQGPERtPGSGTSS molecular association, regulation transcription, inhibited Trap100(DISRUPTS); MED23(DISRUPTS); MED16(DISRUPTS) 27738173 2 0 0 -Adrb3 ADRB3 iso2 GPCR, family 1; Membrane protein, integral; Membrane protein, multi-pass; Receptor, GPCR P25962-2 11556 8 A2|8 15.94 cM mouse S388-p 456901 RQSPPLNsSLLREPR activity, induced 16144970 1 0 0 mutation of serines 388 and 389 to alanine abrogated cAMP accumulation in response to CL316243. -DNMT1 DNMT1 Amino Acid Metabolism - cysteine and methionine; Cell development/differentiation; EC 2.1.1.37; METHYLTRANSFERASE; Methyltransferase; Methyltransferase, DNA; Transcription regulation P26358 1786 19p13.2 human K675-sm 12726307 KACKDMVkFGGSGRS zf-CXXC enzymatic activity, induced DNA(INDUCES) 19450230 1 0 0 -ACE2 ACE2 EC 3.4.17.23; Membrane protein, integral; Protease Q9BYF1 59272 Xp22.2 human Y781-p 465258 ARSGENPyASIDISK molecular association, regulation LYN(INDUCES); Fyn(INDUCES); AP2M1(DISRUPTS) 33436498 2 1 12 -RAB8A RAB8A G protein; G protein, monomeric; G protein, monomeric, Rab; Motility/polarity/chemotaxis; Oncoprotein P61006 4218 19p13.11 human S111-p 20805078 RNIEEHAsADVEKMI Ras molecular association, regulation; enzymatic activity, inhibited; protein conformation; phosphorylation RAB3IP(DISRUPTS); TBC1D20(DISRUPTS) 26471730; 32227113; 34056776 3 11 0 -VDAC1 VDAC1 Channel, misc.; Membrane protein, integral; Mitochondrial P21796 7416 5q31.1 human K274-ub 486986 NVNAGGHkLGLGLEF Porin_3; TM apoptosis, inhibited 32047033 1 9 99 pathologies of PD by controlling apoptosis -ASIC1 ASIC1 Channel, cation; Membrane protein, integral; Membrane protein, multi-pass; Transporter; Transporter, ion channel P78348 41 12q13.12 human S499-p 4737851 KRHNPCEsLRGHPAG activity, inhibited 19091960 1 1 1 -PER2 PER2 Nuclear receptor co-regulator; Nucleolus; Transcription factor O15055 8864 2q37.3 human S662-gl 27717323 ALPGKAEsVASLTSQ phosphorylation 23395175 1 1 0 blocks phosphorylation at S662, regulation of circadian clock -CRK CRK Adaptor/scaffold; Motility/polarity/chemotaxis; Oncoprotein P46108 1398 17p13.3 human Y221-p 447951 GGPEPGPyAQPSVNT molecular association, regulation; intracellular localization apoptosis, induced; cell adhesion, altered; cell adhesion, inhibited Arg(INDUCES); P130Cas(INDUCES); PAX1(DISRUPTS); RAPGEF1(DISRUPTS); Abl iso2(INDUCES); CRK(INDUCES); PXN iso2(DISRUPTS) 12198159; 12799422; 12955086; 25381819; 28790195; 36079767; 8194526 25 14 1168 -CDKN2D CDKN2D Cell cycle regulation; Inhibitor; Tumor suppressor P55273 1032 19p13.2 human S76-p 6046001 VQDTSGTsPVHDAAR Ank_2 protein degradation; molecular association, regulation; ubiquitination; intracellular localization; protein conformation; phosphorylation cell cycle regulation; cell growth, induced CDK6(DISRUPTS) 19063602; 22558186; 29531090; 32874495 3 3 0 -SLC43A2 SLC43A2 Membrane protein, integral; Membrane protein, multi-pass; Transporter; Transporter, SLC family Q8N370 124935 17p13.3 human S297-p 3206079 EGHKLCLsTVDLEVK MFS_1 activity, induced; protein stabilization; intracellular localization 30379325 2 26 0 transporter activity increased, stabilize terminally glycosylated mature form, amino acid absorption -TRIB2 TRB2 KINASE; Kinase, protein; Protein kinase, CAMK; Protein kinase, Ser/Thr (non-receptor) Q92519 28951 2p24.3 human S83-p 29604200 FRAVHLHsGEELVCK Pkinase protein degradation; intracellular localization carcinogenesis, inhibited 24089522 1 0 0 -Hnf4a HNF4 alpha DNA-binding; Nuclear receptor; Transcription factor P49698 15378 2 H3|2 84.32 cM mouse S190-p 458372 NITDVCEsMKEQLLV Hormone_recep molecular association, regulation SSU72(INDUCES) 34616001 2 1 0 -Dlc1 DLC1 GAP; GAP, Rac/Rho; Tumor suppressor Q9R0Z9 50768 8 A4|8 23.05 cM mouse S129-p 20651248 KQDPIPGsPDNSRLQ molecular association, regulation; phosphorylation Src(INDUCES) 31308216 1 11 0 increases the efficiency of Src binding and Src-dependent phosphorylation of Y452 and Y702 -H1-1 H1F1 DNA-binding Q02539 3024 6p22.2 human S183-p 15605000 KPKKVAKsPAKAKAV transcription, altered 20551309 1 3 0 -CAMKK1 CAMKK1 EC 2.7.11.17; KINASE; Kinase, protein; Protein kinase, Other; Protein kinase, Ser/Thr (non-receptor) Q8N5S9 84254 17p13.2 human T108-p 452083 PRAWRRPtIESHHVA enzymatic activity, inhibited; enzymatic activity, induced 11574071 7 0 5 activity toward PKIV peptide; activity towards CAMK4. -ME1 ME1 Carbohydrate Metabolism - pyruvate; EC 1.1.1.40; Oxidoreductase P48163 4199 6q14.2 human S336-p 4701731 KKIWLVDsKGLIVKG Malic_M molecular association, regulation; acetylation; intracellular localization; activity, inhibited carcinogenesis, inhibited ME1(DISRUPTS) 31735643 1 10 0 protein dimerization decreased; decreases acetylation at K337 -LRP6 LRP6 Membrane protein, integral; Receptor, misc. O75581 4040 12p13.2 human T1479-p 457635 SSSSTKGtYFPAILN activity, induced; molecular association, regulation transcription, induced; signaling pathway regulation axin 1(INDUCES) 16341016; 17569865; 35487243 8 1 1 induces WNT signaling -NSUN2 NSUN2 EC 2.1.1.203; METHYLTRANSFERASE; Methyltransferase; Nucleolus; RNA-binding Q08J23 54888 5p15.31 human S139-p 478355 SRKILRKsPHLEKFH molecular association, regulation; intracellular localization; enzymatic activity, inhibited NPM1(DISRUPTS); NCL(INDUCES) 17215513; 25233213 2 0 0 S139E mutant associates with nucleolin (but not with NPM1); tRNA modifying activities are suppressed by phosphorylation; ; reduced in nocodazole-treated cells; S139A mutant (but not S139E mutant) associates with NPM1 (but not with nucleolin) in mitotic cells; dephosphorylated forms of both methyltransferases is able to suppress 5-FU sensitivity; phosphorylation of NSUN2 S139 induces dissociation of NPM1 from the NSUN2/nucleolin complex -NCOA3 SRC-3 ACETYLTRANSFERASE; Acetyltransferase; EC 2.3.1.48; Motility/polarity/chemotaxis; Nuclear receptor co-regulator; Transcription, coactivator/corepressor Q9Y6Q9 8202 20q13.12 human K619-ac 460609 PLESKGHkKLLQLLT SRC-1 molecular association, regulation transcription, inhibited ER-alpha(DISRUPTS) 10490106 1 0 0 -BCAR1 P130Cas Adaptor/scaffold; Motility/polarity/chemotaxis P56945 9564 16q23.1 human Y327-p 448780 PLLREETyDVPPAFA molecular association, regulation; acetylation DNA repair, induced; transcription, induced RBBP4(INDUCES) DNA(INDUCES) 37182100 2 19 195 induces H4K16 acetylation -Tp53 p53 Activator; DNA-binding; Motility/polarity/chemotaxis; Nuclear receptor co-regulator; Transcription factor; Tumor suppressor P02340 22059 11 B3|11 42.83 cM mouse K367-ub 464661 RAHSSYLkTKKGQST transcription, altered 15964796 9 1 0 p53K6R (K378/383/369/379/367/370/R) mutant is still ubiquitinated and shows normal stability of p53 before and after DNA damage -DPYSL2 CRMP-2 iso3 Microtubule-binding; Motility/polarity/chemotaxis NP_001184222 1808 8p21.2 human S27-p 23053573 FKNLGSGsPKPRQKF protein degradation; protein stabilization; molecular association, regulation cell growth, induced PIN1(INDUCES) 26489457 1 9 1 axon growth in vitro -HPCAL1 HPCAL1 Calcium-binding P37235 3241 2p25.1 human T149-p 1876861206 ESTPEKRtDKIFRQM EF-hand_7 carcinogenesis, inhibited; autophagy, induced; cell growth, inhibited 35403545 1 0 0 -HTT Huntingtin Cytoskeletal P42858 3064 4p16.3 human K9-sm 8545503 ATLEKLMkAFESLKS protein stabilization; intracellular localization transcription, inhibited 15064418 2 0 0 -BAIAP2L1 IRTKS Adaptor/scaffold; Cytoskeletal Q9UHR4 55971 7q21.3-q22.1 human Y439-p 462517 VVIPPPDyLECLSMG cell motility, induced 21840312 1 0 3 -RET Ret EC 2.7.10.1; KINASE; Kinase, protein; Membrane protein, integral; Oncoprotein; Protein kinase, TK; Protein kinase, tyrosine (receptor) P07949 5979 10q11.21 human Y864-p 447626 QISQGMQyLAEMKLV PK_Tyr_Ser-Thr enzymatic activity, induced cell growth, altered 8637703 1 0 0 -ITGB2 ITGB2 Cell adhesion; Cell surface; Membrane protein, integral; Motility/polarity/chemotaxis; Receptor, misc. P05107 3689 21q22.3 human T758-p 448533 NPLFKSAtTTVMNPK Integrin_b_cyt molecular association, regulation; phosphorylation cell motility, induced; cell adhesion, induced; cytoskeletal reorganization; cell adhesion, altered; signaling pathway regulation 14-3-3 beta(INDUCES); FLNA(DISRUPTS); ACTN1(INDUCES); 14-3-3 zeta(INDUCES); kindlin-3(INDUCES) 11700305; 16301335; 17107954; 18550856; 23823319; 25278023; 29903913 8 2 3 -Snph syntaphilin iso4 Membrane protein, integral; Vesicle AAI39793 241727 2|2 G3 mouse S71-p 451012 PPLTRTRsLMAMSLQ molecular association, regulation STX1A(DISRUPTS) 14985338 1 0 0 -DUSP1 DUSP1 EC 3.1.3.16; EC 3.1.3.48; Motility/polarity/chemotaxis; PHOSPHATASE; Protein phosphatase, dual-specificity P28562 1843 5q35.1 human S323-p 457718 HCSAEAGsPAMAVLD protein degradation; molecular association, regulation SKP2(INDUCES) 16286470 1 0 0 MKP-1 is a substrate for Skp2 ligase -CRTC1 TORC1 Transcription factor Q6UUV9 23373 19p13.11 human S151-p 481986 TSWRRTNsDSALHQS TORC_M intracellular localization 20010869 7 17 5 Nuclear export -FEN1 FEN1 DNA repair, damage; DNA-binding; Deoxyribonuclease; EC 3.1.-.-; Nuclear receptor co-regulator; Nucleolus; Ribonuclease P39748 2237 11q12.2 human K375-ac 458856 AKTGAAGkFKRGK__ molecular association, regulation; enzymatic activity, inhibited DNA(DISRUPTS) 11430825 1 3 34 -HSF1 HSF1 DNA-binding; Transcription factor Q00613 3297 8q24.3 human S314-p 455482 SPRVEEAsPGRPSSV Vert_HS_TF transcription, inhibited 25963659 4 32 12 under non-stressed conditions, upon heat shock S to A mutant showed 60% higher luciferase activity -Pde3b PDE3B EC 3.1.4.17; Membrane protein, integral; Membrane protein, multi-pass; Nucleotide Metabolism - purine; Phosphodiesterase Q61409 18576 7 F1|7 59.46 cM mouse S273-p 447699 VIRPRRRsSCVSLGE enzymatic activity, induced 10454575 4 7 78 -Crtc2 TORC2 Transcription, coactivator/corepressor Q3U182 74343 3|3 F1 mouse S70-p 454630 RSSHYGGsLPNVNQI TORC_N molecular association, regulation; intracellular localization transcription, altered 14-3-3 beta(INDUCES) 18323454 1 30 33 -Cckar CCKAR GPCR, family 1; Membrane protein, integral; Membrane protein, multi-pass; Receptor, GPCR P30551 24889 14q11 rat S264-p 451124 FDASQKKsAKEKKPS 7tm_1 receptor desensitization, altered 11078715; 9203622 2 0 0 Constructs modifying S264 delayed the onset of desensitization. -MAP3K5 ASK1 EC 2.7.11.25; KINASE; Kinase, protein; Protein kinase, STE; Protein kinase, Ser/Thr (non-receptor) Q99683 4217 6q23.3 human T838-p 448394 GINPCTEtFTGTLQY Pkinase molecular association, regulation; phosphorylation; enzymatic activity, induced cell cycle regulation; carcinogenesis, induced; apoptosis, altered; apoptosis, induced; cell adhesion, altered; transcription, altered TXN(DISRUPTS); 14-3-3 beta(DISRUPTS) 17671211; 17937911; 25633196; 28888991; 33399853 20 2 1 Regulates invadosome formation -FOXA1 FOXA1 DNA-binding; Transcription factor P55317 3169 14q21.1 human K264-ac 11263048 GCYLRRQkRFKCEKQ molecular association, regulation chromatin organization, altered DNA(DISRUPTS) 19897491 1 0 0 -CERS2 LASS2 DNA-binding; Membrane protein, integral; Membrane protein, multi-pass; Transferase Q96G23 29956 1q21.3 human S341-p 470692 KLVEDERsDREETES enzymatic activity, induced 26887952 1 47 217 -STAT5B STAT5B DNA-binding; Oncoprotein; Transcription factor P51692 6777 17q21.2 human Y740-p 448735 AVCPQAHyNMYPQNP activity, inhibited transcription, altered; transcription, inhibited 16772534; 17822672 4 0 0 transcriptional activation of STAT5B Y740/743 mutant requires phosphorylation of S731 and Y699 -DES desmin Cytoskeletal; Motility/polarity/chemotaxis P17661 1674 2q35 human S32-p 466343 PLGSPLSsPVFPRAG Filament_head protein conformation 29483093 4 13 31 formation of desmin-positive aggregates, decreased Z-bands incorporation -RBL2 Rb-like 2 Transcription, coactivator/corepressor; Tumor suppressor Q08999 5934 16q12.2 human T417-p 449725 KENSPCVtPVSTATH RB_A molecular association, regulation cell cycle regulation E2F4(DISRUPTS) 11157749 2 16 3 -IQGAP1 IQGAP1 GAP; GAP, Ras; Motility/polarity/chemotaxis P46940 8826 15q26.1 human K1230-ub 22246214 RNLGSIAkMLQHAAS RasGAP molecular association, regulation CDC42(INDUCES); RAC1(INDUCES) 32094223 1 4 0 6KR mutant compared to WT; no effect of K1155R or K1230R mutants on CDC42 or Rac binding -Ppargc1b PGC-1 beta Nuclear receptor co-regulator; Transcription, coactivator/corepressor Q8VHJ7 170826 18|18 E1 mouse K674-ac 7761210 PVSQAGQkRPFSCSF intracellular localization transcription, inhibited 19491097 1 1 0 -Etv1 ETV1 DNA-binding; Oncoprotein; Transcription factor P41164 14009 12 A3|12 17.99 cM mouse S146-p 3059603 TPSSTPVsPLHHASP ETS_PEA3_N activity, induced transcription, induced; signaling pathway regulation 22586091 2 1 0 -ILF2 ILF2 Nucleolus; RNA-binding; Transcription, coactivator/corepressor Q12905 3608 1q21.3 human K45-ub 12287558 EMAFPRVkPAPDETS protein degradation 33009960 1 10 40 -Tjp1 ZO1 Adaptor/scaffold; Motility/polarity/chemotaxis P39447 21872 7 C|7 35.02 cM mouse S168-p 470469 ASRERSLsPRSDRRS cytoskeletal reorganization 23967087 2 16 11 necessary for cytokinesis -AKTIP AKTIP Apoptosis; Membrane protein, peripheral; Vesicle Q9H8T0 64400 16q12.2 human S237-p 1876861202 IEDPYAIsFSPWNPS phosphorylation carcinogenesis, induced; cell growth, induced 35366279 1 1 0 -TERF2 TRF2 DNA repair, damage; DNA-binding Q15554 7014 16q22.1 human R55-me 10338215 GSSDGSGrAAGRRAS cell cycle regulation; cell growth, altered 19596784 1 0 0 -Sstr2 SSTR2 GPCR, family 1; Membrane protein, integral; Membrane protein, multi-pass; Receptor, GPCR P30875 20606 11 E2|11 79.05 cM mouse Y228-p 450819 LTIICLCyLFIIIKV 7tm_1; TM molecular association, regulation SHP-2(INDUCES) 12972574 1 0 0 -Creb1 CREB iso1 DNA-binding; Transcription factor P15337-1 81646 9q32 rat K94-ac 459098 QSSCKDLkRLFSGTQ transcription, inhibited 12595525 1 0 0 modulating CREB-mediated gene expression -Pias1 PIAS1 EC 6.3.2.-; Nuclear receptor co-regulator; SUMO LIGASE; SUMO conjugating system; SUMO ligase; Transcription, coactivator/corepressor O88907 56469 9|9 B mouse S90-p 479880 SPMPPTLsPSTIPQL transcription, inhibited 17540171 1 1 0 ; phosphorylation of this site inhibits TNF-induced expression of NFKB-target genes and IFN-induced expression of STAT1-target genes -Tnp2 TP2 DNA-binding P11101 24840 10q11 rat S109-p 450902 HRAKRRSsGRRYK__ TP2 intracellular localization 14514679 1 0 0 -LRRK1 LRRK1 EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, Ser/Thr (non-receptor); Protein kinase, TKL Q38SD2 79705 15q26.3 human S1817-p 41694201 GDSIADVsIMYSEEL molecular association, regulation; enzymatic activity, induced cytoskeletal reorganization WDR34(INDUCES); WDR60(INDUCES) 26192437; 36254578 2 0 0 -Stk11 LKB1 Autophagy; EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, CAMK; Protein kinase, Ser/Thr (non-receptor); Tumor suppressor Q9WTK7 20869 10|10 C1 mouse T336-p 448150 KDRWRSMtVVPYLED activity, inhibited cell growth, altered 11853558 2 0 0 -IGF1R IGF1R EC 2.7.10.1; KINASE; Kinase, protein; Membrane protein, integral; Protein kinase, TK; Protein kinase, tyrosine (receptor) P08069 3480 15q26.3 human S1310-p 2091903 VPLDPSAsSSSLPLP activity, induced; phosphorylation cell differentiation, altered; apoptosis, altered; cell growth, altered 10746631; 10786694 2 0 0 observed in Y980F + S1310-1313A; ERK phosphorylation -ATF4 ATF-4 DNA-binding; Transcription factor P18848 468 22q13.1 human T107-p 40420006 LGIDDLEtMPDDLLT protein degradation transcription, inhibited 25795775 1 1 0 -SMAD4 SMAD4 DNA-binding; Nuclear receptor co-regulator; Transcription, coactivator/corepressor Q13485 4089 18q21.2 human Y195-p 1881244700 NRASTETySTPALLA molecular association, regulation cell cycle regulation; carcinogenesis, induced; cell growth, induced; transcription, inhibited p300(DISRUPTS); CBP(DISRUPTS); H3(DISRUPTS) 36959211 1 1 0 binding to p300 promotes p300 binding to DNA -GLE1 GLE1 Karyopherin; Nuclear export Q53GS7 2733 9q34.11 human S99-p 18010022 SSAFSPAsPATPNGT molecular association, regulation GLE1(INDUCES) 30429220 1 10 0 self-association stress granules' assembly and disassembly, DDX3-ATPase activity inhibited -ITGB4 ITGB4 iso2 Cell adhesion; Membrane protein, integral; Motility/polarity/chemotaxis; Receptor, misc. P16144-2 3691 17q25.1 human S1424-p 465821 TLTRDYNsLTRSEHS intracellular localization carcinogenesis, induced 22824799 2 14 31 decreased phosphorylation of this site and cells invasion of CD151-depleted A431 cells -LMO7 LMO7 iso3 Adaptor/scaffold Q8WWI1-3 4008 13q22.2 human S863-p 478135 LKNLKRRsQFFEQGS molecular association, regulation; phosphorylation carcinogenesis, inhibited; cell growth, inhibited; transcription, induced; signaling pathway regulation STING(INDUCES) 33767426 1 12 39 binding to STING induces STING-TBK1 binding and TBK1 autophosphorylation, regulates STING?IFN-? pathway -Dusp4 DUSP4 EC 3.1.3.16; EC 3.1.3.48; PHOSPHATASE; Protein phosphatase, dual-specificity Q8BFV3 319520 8|8 A4 mouse T363-p 15412237 ERGKATPtPTSQFVF protein stabilization 22430215 1 0 1 -Ndel1 NDEL1 Microtubule-binding; Protease Q9ERR1 83431 11|11 B3 mouse S231-p 474507 GTENSFPsPKAIPNG NUDE_C activity, induced; intracellular localization cell motility, altered 18331715 5 18 0 Cdc42 activation -Crebbp CBP ACETYLTRANSFERASE; Acetyltransferase; DNA-binding; EC 2.3.1.48; Motility/polarity/chemotaxis; Nuclear receptor co-regulator; Transcription, coactivator/corepressor P45481 12914 16 A1|16 2.4 cM mouse S301-p 448068 PQLASKQsMVNSLPA transcription, induced 11970865 1 0 0 -TGFBR2 TGFBR2 EC 2.7.11.30; KINASE; Kinase, protein; Membrane protein, integral; Oncoprotein; Protein kinase, Ser/Thr (receptor); Protein kinase, TKL P37173 7048 3p24.1 human S213-p 452047 TRKLMEFsEHCAIIL cell growth, altered 9155023 1 0 0 -MTHFR MTHFR Cofactor and Vitamin Metabolism - one carbon pool by folate; EC 1.5.1.20; Energy Metabolism - methane; Oxidoreductase P42898 4524 1p36.22 human T34-p 456129 KDSSRCStPGLDPER molecular association, regulation; enzymatic activity, inhibited; activity, inhibited PLK1(INDUCES) 16024724; 24769206; 28820331 3 2 2 -RB1 Rb Nuclear receptor co-regulator; Oncoprotein; Transcription, coactivator/corepressor; Tumor suppressor P06400 5925 13q14.2 human K810-m2 34823404 NIYISPLkSPYKISE Rb_C molecular association, regulation cell cycle regulation; DNA repair, induced; carcinogenesis, inhibited; cell growth, inhibited PHF20L1(INDUCES); 53BP1(INDUCES) 25049398; 28841214 2 0 0 -ACLY ACLY Carbohydrate Metabolism - citrate (TCA) cycle; EC 2.3.3.8; Lyase; Transferase P53396 47 17q21.2 human K86-ac 11323415 DGVKSWLkPRLGQEA protein degradation; molecular association, regulation cell growth, altered ARHGEF3(INDUCES) 36241648 1 4 0 -AKAP12 AKAP12 Adaptor/scaffold Q02952 9590 6q25.1 human S772-p 34663200 LVTPRKKsKSKLEEK WSK receptor desensitization, inhibited; molecular association, regulation ADRB2(INDUCES) 14657015 1 1 0 -FLT3 FLT3 EC 2.7.10.1; KINASE; Kinase, protein; Membrane protein, integral; Oncoprotein; Protein kinase, TK; Protein kinase, tyrosine (receptor) P36888 2322 13q12.2 human Y597-p 450033 FYVDFREyEYDLKWE phosphorylation 11971190 2 0 0 however, in the FLT3-ITD mutant, there is only a slight decrease in its phosphotyrosine content and this mutation does not alter its transforming capabilities (and STAT5a and MAPK activation and SHC phosphorylation).; Mutation of all 4 sites from Y->F abrogates the phosphotyrosine content of wt-FLT3 -EEF2K EEF2K EC 2.7.11.20; KINASE; Kinase, protein; Protein kinase, Ser/Thr (non-receptor); Protein kinase, atypical; Translation O00418 29904 16p12.2 human S366-p 447827 SPQVRTLsGSRPPLL enzymatic activity, inhibited; phosphorylation; enzymatic activity, induced autophagy, inhibited; translation, induced 22216903; 23182879; 35841486 16 11 20 inhibits EEf2 phosphorylation -AKT1 Akt1 EC 2.7.11.1; KINASE; Kinase, protein; Oncoprotein; Protein kinase, AGC; Protein kinase, Ser/Thr (non-receptor) P31749 207 14q32.33 human T291-p 28706900 KDGHIKItDFGLCKE Pkinase signaling pathway regulation 23768697 0 1 0 PI3K-Akt-eNOS signaling pathway -MCL1 MCL1 Apoptosis; Channel, misc.; Inhibitor; Membrane protein, integral; Mitochondrial Q07820 4170 1q21.2 human S64-p 479431 IGGSAGAsPPSTLTP protein degradation; protein stabilization; molecular association, regulation; ubiquitination carcinogenesis, induced; apoptosis, induced; apoptosis, inhibited BIM(INDUCES); HUWE1(DISRUPTS); NOXA1(INDUCES) 17463001; 26219338; 27166195; 27738316; 36171331 8 6 0 -VAV1 VAV1 GEF; GEF, Rac/Rho; Motility/polarity/chemotaxis; Oncoprotein P15498 7409 19p13.3 human Y174-p 447866 EAEGDEIyEDLMRSE activity, induced; molecular association, regulation; intracellular localization; activity, inhibited cell differentiation, altered; cytoskeletal reorganization; transcription, inhibited; cell growth, altered PLCG1(INDUCES); Lck(INDUCES); PIK3R1(INDUCES) 10636924; 17050525; 24332539 22 2 0 extracellular matrix degradation, invadopodia formation through Cdc42 -RAB11FIP2 RAB11FIP2 Cytoskeletal Q7L804 22841 10q26.11 human S227-p 465674 QRLSSAHsMSDLSGS cell differentiation, altered; cytoskeletal reorganization 16775013; 22553350 3 17 0 regulates cell polarity, alters the composition of cellular junctions; important for formation of junctional complexes and cell polarity -Nrf1 NRF1 DNA-binding; Transcription factor Q9WU00 18181 6 A3.3|6 12.47 cM mouse S318-p 1883500600 SNPDGTVsLIQVGTG molecular association, regulation transcription, induced DNA(DISRUPTS) 37409632 1 0 0 -ATM ATM DNA repair, damage; EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, Ser/Thr (non-receptor); Protein kinase, atypical; Tumor suppressor Q13315 472 11q22.3 human S1988-p 62382602 SQSTTISsLSEKSKE enzymatic activity, inhibited; protein conformation cell cycle regulation; apoptosis, inhibited 27939942 1 0 0 -RPTOR Raptor Adaptor/scaffold Q8N122 57521 17q25.3 human S771-p 13251700 SASSTLGsPENEEHI activity, induced 21757713 2 1 0 mTORC1 activation -Rab29 RAB29 G protein; G protein, monomeric; G protein, monomeric, Rab Q63481 171122 13q13 rat S72-p 396518800 AGQERFTsMTRLYYR Ras molecular association, regulation 29223392 2 0 0 located at an interface that mediates binding with other interactors; modi?cation of morphology and distribution of the trans-Golgi -Ttll4 TTLL4 EC 6.-.-.-; Ligase Q80UG8 67534 1|1 C4 mouse S1136-p 36123708 KKSQAGLsPISRKTL enzymatic activity, induced 34084286 1 2 0 -NKX3-1 NKX3-1 DNA-binding; Transcription factor; Tumor suppressor Q99801 4824 8p21.2 human S186-p 7998431 TKRKQLSsELGDLEK protein stabilization 23129228 2 1 1 -GPBAR1 GPBAR1 GPCR, family 1; Membrane protein, integral; Membrane protein, multi-pass; Receptor, GPCR Q8TDU6 151306 2q35 human S324-p 1877729206 YHPSSQSsVDLDLN_ molecular association, regulation cell growth, induced; apoptosis, inhibited ARRB1(INDUCES) 35858343 0 1 0 -PAK1 PAK1 EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, STE; Protein kinase, Ser/Thr (non-receptor) Q13153 5058 11q13.5-q14.1 human K39-ub 56714904 GTLNHGSkPLPPNPE protein degradation 27302166 1 0 0 -DVL2 DVL2 Adaptor/scaffold; Motility/polarity/chemotaxis O14641 1856 17p13.1 human K54-ub 40724400 LQRPAGAkYFFKSMD DIX protein conformation 25907794 1 0 0 inhibits DVL2 polymerization by attenuating filament assembly -Itgb1 ITGB1 Cell adhesion; Cell surface; Membrane protein, integral; Motility/polarity/chemotaxis; Receptor, misc. P09055 16412 8|8 E2 mouse Y795-p 447711 TTVVNPKyEGK____ Integrin_b_cyt cell motility, altered; cell adhesion, altered 10891511; 11259684 7 13 211 -Aqp2 AQP2 Channel, misc.; Membrane protein, integral; Membrane protein, multi-pass; Transporter; Transporter, aquaporin family P56402 11827 15 F1|15 56.13 cM mouse S264-p 2238600 VELHSPQsLPRGSKA molecular association, regulation; intracellular localization 14-3-3 theta(INDUCES) 19966308; 26645691 20 8 0 -DAPK1 DAPK1 Apoptosis; Autophagy; EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, CAMK; Protein kinase, Ser/Thr (non-receptor) P53355 1612 9q21.33 human Y491-p 487484 CAAWHGYySVAKALC Ank_2 enzymatic activity, inhibited; protein conformation carcinogenesis, induced; cell motility, induced; cell adhesion, induced; apoptosis, inhibited 17803936 1 0 0 -TACC3 TACC3 Cell cycle regulation F1NCL7 422899 chicken S575-p 474537 ESALRKQsLYLKFDP molecular association, regulation cytoskeletal reorganization AP1B1(INDUCES) 26134678 12 15 43 stabilization of spindle microtubules -Map2 MAP2 iso3 Cytoskeletal; Motility/polarity/chemotaxis P15146-3 25595 9q32 rat K230-ac 62495501 EPIRRAGkSGTSTPT cytoskeletal reorganization 28002468 1 1 0 -Pim1 Pim1 EC 2.7.11.1; KINASE; Kinase, protein; Oncoprotein; Protein kinase, CAMK; Protein kinase, Ser/Thr (non-receptor) P06803 18712 17 A3.3|17 15.38 cM mouse Y218-p 451014 EWIRYHRyHGRSAAV Pkinase activity, induced 14981536 1 0 0 -Bcl2l1 Bcl-xL Apoptosis; Autophagy; Membrane protein, integral; Mitochondrial Q64373 12048 2 75.41 cM|2 H1 mouse S14-p 33668512 ELVVDFLsYKLSQKG BH4 molecular association, regulation apoptosis, induced; signaling pathway regulation BIM(INDUCES); BID(INDUCES); BAX(DISRUPTS) 24813943; 27218122 3 1 0 -RUNX1 AML1 DNA-binding; Oncoprotein; Transcription factor Q01196 861 21q22.12 human S276-p 454401 VHPATPIsPGRASGM molecular association, regulation transcription, induced HDAC1(INDUCES); SIN3A(INDUCES) 34673281 13 11 70 -NRIP1 RIP140 Nuclear receptor co-regulator; Transcription, coactivator/corepressor P48552 8204 21q11.2-q21.1 human R947-m1 2363400 LLSENCVrDLSPHRS NRIP1_repr_4 molecular association, regulation; intracellular localization transcription, induced Exportin-1(INDUCES) DNA(DISRUPTS) 17053781 2 2 0 -PLCG2 PLCG2 Carbohydrate Metabolism - inositol phosphate; EC 3.1.4.11; Motility/polarity/chemotaxis; Phospholipase P16885 5336 16q23.3 human S1164-p 25692906 AVKSGFRsVPLKNGY C2 signaling pathway regulation 22759789 1 0 0 B cell receptor signaling -NOXA1 NOXA1 Activator Q86UR1 10811 9q34.3 human S172-p 990300 DQVQRRGsLPPRQVP molecular association, regulation; intracellular localization; enzymatic activity, inhibited RAC1(DISRUPTS); 14-3-3 zeta(INDUCES); NOX1(DISRUPTS) 17913709; 20110267 2 0 0 regulates association with 14-3-3 and dissociation from Nox1, which in-turn inhibits Nox1 activity and production of ROS; prevents hyperactivation of NOX1 -LRP2 LRP2 Membrane protein, integral; Motility/polarity/chemotaxis; Receptor, misc. P98164 4036 2q31.1 human T4641-p 767907 TYSATEDtFKDTANL receptor internalization, altered; receptor recycling, altered 17555532 1 0 1 -SCN5A SCN5A Channel, sodium; Membrane protein, integral; Membrane protein, multi-pass Q14524 6331 3p22.2 human T670-p 40558327 LSAVSVLtSALEELE protein conformation 33410863 1 2 0 -HDAC2 HDAC2 DEACETYLASE; Deacetylase; EC 3.5.1.98; Nuclear receptor co-regulator; Transcription, coactivator/corepressor P56519 395635 chicken S411-p 13373500 KRISIRAsDKRIACD molecular association, regulation MBD3(DISRUPTS); HDAC2(INDUCES); MTA1(DISRUPTS) 33596269 3 3 0 promotes homodimerization -CIITA CIITA DNA-binding; EC 2.7.11.1; KINASE; Protein kinase, Ser/Thr (non-receptor); Transcription, coactivator/corepressor P33076 4261 16p13.13 human S280-p 471421 TVHGLPTsPDRPGST protein degradation; protein stabilization; molecular association, regulation; ubiquitination; intracellular localization transcription, induced CCNT1(INDUCES) 17095509; 26181363 3 0 0 MHC II transcription, global ubiquitination levels, CIITA nuclear mobilization -Map1b MAP1B Cytoskeletal; Motility/polarity/chemotaxis P14873 17755 13 D1|13 52.9 cM mouse T1265-p 455476 PPSPIEKtPLGERSV cytoskeletal reorganization 15731007 2 9 3 induces a loss of stable microtubules -LATS2 LATS2 EC 2.7.11.1; KINASE; Kinase, protein; Nuclear receptor co-regulator; Protein kinase, AGC; Protein kinase, Ser/Thr (non-receptor); Tumor suppressor Q9NRM7 26524 13q12.11 human S83-p 451703 ALREIRYsLLPFANE intracellular localization cell cycle regulation 15147269; 21788394 4 0 0 -MALT1 MALT1 Adaptor/scaffold; Apoptosis; EC 3.4.22.-; Ligase; Nuclear export; Protease; UBIQUITIN LIGASE; Ubiquitin conjugating system Q9UDY8 10892 18q21.32 human K724-ub 2134706 MHRGLGRkTCFQTCL protein degradation; molecular association, regulation IKKA(INDUCES) 17948050 1 0 0 activation of NF-kB pathway and IL-2 induction -SRSF1 SF2 RNA splicing; RNA-binding; Spliceosome Q07955 6426 17q22 human R109-m1 9291750 GGGGGAPrGRYGPPS intracellular localization RNA splicing, induced; RNA stability, inhibited; translation, induced 20308322 1 7 40 prevents SF2 nuclear import and splicing of target genes, and translation is increased in the cytoplasm -RPS6KB1 p70S6K iso2 EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, AGC; Protein kinase, Ser/Thr (non-receptor); Translation P23443-2 6198 17q23.1 human K484-ac 32640201 QPNSGPYkKQAFPMI molecular association, regulation; enzymatic activity, inhibited; phosphorylation transcription, inhibited Raptor(DISRUPTS) 24652283; 31028173 3 0 0 inhibits mesangial cell hypertrophy and expression of fibronectin and collagen I ; Sirt1,2 deacetylate p70S6K which enhances T389 phosphorylation and it's kinase activity -Ppp2r5d PPP2R5D Motility/polarity/chemotaxis; PHOSPHATASE; Protein phosphatase, regulatory subunit Q7TNL5 21770 17 22.9 cM|17 C mouse S68-p 457389 QLSKIKYsGGPQIVK enzymatic activity, induced 20106966 4 5 0 -Homer1 HOMER1 Adaptor/scaffold; Cell development/differentiation Q9Z2Y3 26556 13|13 C3 mouse S117-p 51633300 ARLAKEKsQEKMELT molecular association, regulation GluR5(DISRUPTS) 26670047 1 0 0 circuit hyperexcitability in fragile X syndrome -HMGN1 HMGN1 DNA-binding; Nuclear receptor co-regulator P05114 3150 21q22.2 human K14-ac 458842 SSAEGAAkEEPKRRS HMG14_17 molecular association, regulation DNA(DISRUPTS) 10753971 1 5 13 -Pah PAH Amino Acid Metabolism - phenylalanine, tyrosine and tryptophan biosynthesis; EC 1.14.16.1; Oxidoreductase P04176 24616 7q13 rat S16-p 449074 GVLSRKLsDFGQETS protein conformation 12142458; 23537590 7 7 36 -Wasf1 WAVE1 Cytoskeletal; Motility/polarity/chemotaxis Q8R5H6 83767 10 B1|10 22.07 cM mouse S397-p 7979603 APPLVQPsPPVARAA activity, inhibited 20403076 4 2 0 -LSM4 LSM4 RNA-binding; Spliceosome Q9Y4Z0 25804 19p13.11 human R88-m2 15381287 EEVVAKGrGRGGLQQ molecular association, regulation SMN(INDUCES) 11720283 1 2 1 -YAP1 YAP1 iso3 Oncoprotein; Transcription, coactivator/corepressor P46937-3 10413 11q22.1 human Y341-p 15565111 PFLNSGTyHSRDEST activity, induced; molecular association, regulation; intracellular localization carcinogenesis, induced; cell growth, induced; transcription, induced TEAD1(INDUCES) 27013234 6 4 3 -Acaca ACC1 Carbohydrate Metabolism - propanoate; Carbohydrate Metabolism - pyruvate; EC 6.3.4.14; EC 6.4.1.2; Ligase; Lipid Metabolism - fatty acid biosynthesis P11497 60581 10q26 rat S79-p 448292 FHMRSSMsGLHLVKQ enzymatic activity, inhibited 12015362; 1688796; 1967580; 7915280 166 76 11 -ERBB4 HER4 EC 2.7.10.1; KINASE; Kinase, protein; Membrane protein, integral; Protein kinase, TK; Protein kinase, tyrosine (receptor) Q15303 2066 2q34 human Y1268-p 4825104 EYSTKYFyKQNGRIR molecular association, regulation GRB2(INDUCES); NCK2(INDUCES) 16729043 1 1 0 -SNAI1 Snail1 C2H2-type zinc finger protein; Transcription factor O95863 6615 20q13.13 human K206-ub 231166702 VRTHTGEkPFSCPHC protein stabilization 28892081 1 0 0 metastasis -SP7 osterix C2H2-type zinc finger protein; DNA-binding; Transcription factor Q8TDD2 121340 12q13.13 human S80-p 15334101 GLLSPAGsPPAPTSG molecular association, regulation transcription, induced AML3(INDUCES) 25122769; 27498006 4 0 0 transcriptional activity on the Cx43 promoter -CDKN1C p57Kip2 Cell cycle regulation; Inhibitor; Nuclear receptor co-regulator; Tumor suppressor P49918 1028 11p15.4 human S282-p 9318134 FFAKRKRsAPEKSSG protein degradation 23421998 1 0 0 DN-Akt stabilized p57 -ITGB7 ITGB7 Cell adhesion; Membrane protein, integral; Motility/polarity/chemotaxis; Receptor, misc. P26010 3695 12q13.13 human T785-p 464649 YKSAITTtINPRFQE Integrin_b_cyt molecular association, regulation FLNA(DISRUPTS) 16455489 1 0 0 based on glutamate mutant of threonine site -Sirt1 SIRT1 Apoptosis; DEACETYLASE; Deacetylase; EC 3.5.1.-; Nuclear receptor co-regulator Q923E4 93759 10|10 B4 mouse S649-p 6855923 FHGAEVYsDSEDDVL enzymatic activity, induced apoptosis, inhibited 19680552 2 0 0 deacetylates p53 K382 and NFkB-p65 -FERMT2 kindlin-2 Cytoskeletal; Motility/polarity/chemotaxis Q96AC1 10979 14q22.1 human K154-ub 964523622 PTKKKKKkLDDQSED protein degradation cell adhesion, inhibited 28408404 1 1 0 -Nr2c2 NR2C2 DNA-binding; Nuclear receptor; Transcription factor P49117 22026 6|6 D1 mouse S68-p 467310 TGKVILAsPETSSAK activity, inhibited transcription, altered 16887930 1 14 0 -Havcr2 TIM-3 Membrane protein, integral; Receptor, misc. Q8VIM0 171285 11|11 B1.1 mouse Y263-p 26371002 YTIEENVyEVENSNE molecular association, regulation BAT3(DISRUPTS) 22863785 4 0 0 -Sh3gl1 endophilin A2 Oncoprotein; Vesicle Q62419 20405 17 D|17 29.11 cM mouse Y315-p 450745 QPSCKALyDFEPEND SH3_1 carcinogenesis, induced; cell motility, induced; transcription, altered; endocytosis, inhibited 23255596 2 2 3 induces surface expression of MT1-MMP by inhibiting its endocytosis -CEBPA C/EBP-alpha DNA-binding; Transcription factor P49715 1050 19q13.11 human S190-p 457552 PPPPPPPsHPHPHPP protein degradation; molecular association, regulation carcinogenesis, inhibited; cell growth, inhibited; cell differentiation, induced; transcription, induced HDAC1(DISRUPTS); PSMD10(INDUCES) 29159818; 34245919 2 0 0 -Trp53 p53 iso2 Activator; DNA-binding; Motility/polarity/chemotaxis; Nuclear receptor co-regulator; Transcription factor; Tumor suppressor Q80ZA1 22059 11 B3|11 42.83 cM mouse K161-ac 2793003 VRAMAIYkKSQHMTE P53 transcription, induced 27705786 12 1 0 -GLUL GLUL Amino Acid Metabolism - alanine, aspartate and glutamate; Amino Acid Metabolism - arginine and proline; EC 4.1.1.15; EC 6.3.1.2; Energy Metabolism - nitrogen; Ligase P15104 2752 1q25.3 human K11-ac 55588404 SASSHLNkGIKQVYM protein degradation; molecular association, regulation; ubiquitination CRBN(INDUCES) 26990986 1 1 0 -Rxra RXRA DNA-binding; Motility/polarity/chemotaxis; Nuclear receptor P28700 20181 2 A3|2 19.38 cM mouse S22-p 453093 VNSSSLNsPTGRGSM Nuc_recep-AF1 cell cycle regulation; transcription, altered; cell growth, altered 12032153 4 12 4 -S100A9 S100A9 Calcium-binding; Cell development/differentiation; Motility/polarity/chemotaxis P06702 6280 1q21.3 human T113-p 455888 KPGLGEGtP______ activity, induced; intracellular localization cytoskeletal reorganization 15905572; 17429438 4 14 22 -NOS3 eNOS Amino Acid Metabolism - arginine and proline; EC 1.14.13.39; Oxidoreductase P29473 287024 cow S617-p 448656 SYKIRFNsVSCSDPL Flavodoxin_1 molecular association, regulation; enzymatic activity, induced; phosphorylation HSP90A(DISRUPTS); Akt1(DISRUPTS) 12591925; 16257964; 19251696 13 5 0 -SH3BP2 SH3BP2 Adaptor/scaffold P78314 6452 4p16.3 human Y448-p 449093 GDDSDEDyEKVPLPN molecular association, regulation transcription, altered Lck(INDUCES) 15751964 5 0 0 -H3F3C H3 DNA-binding P84229 427887 chicken K27-m3 1308913 LATKAARkSAPATGG Histone chromatin organization, altered; transcription, inhibited 23028147 195 24 3 -Adcy6 ADCY6 Adenylyl cyclase; EC 4.6.1.1; Lyase; Membrane protein, integral; Membrane protein, multi-pass; Nucleotide Metabolism - purine; Transporter; Transporter, aquaporin family AAA40678 25289 7q36 rat S10-p 450817 LPVARSGsGRSSMSW enzymatic activity, inhibited 11877398 2 0 0 -Cyth3 cytohesin 3 GEF; GEF, ARF; Lipid-binding; Nuclear receptor co-regulator; Receptor, misc. O08967 19159 5 G2|5 82.36 cM mouse S155-p 25585001 ALRQFLWsFRLPGEA Sec7 receptor recycling, induced 22609160 1 0 0 Glut4 vesicle formation -MAP3K7 TAK1 EC 2.7.11.25; KINASE; Kinase, protein; Protein kinase, Ser/Thr (non-receptor); Protein kinase, TKL O43318 6885 6q15 human K209-ub 11956706 EGSNYSEkCDVFSWG PK_Tyr_Ser-Thr protein stabilization; molecular association, regulation; phosphorylation apoptosis, induced; signaling pathway regulation MEKK3(INDUCES) 19843958; 23770285 3 0 0 induces stabilization of Traf6-MEKK3-TAK1 complex, regulates IL1 -induced NF-kB activation pathway; autophosphorylation of TAK1, and activation of JNK and p38 -TRPC3 TRPC3 Channel, cation; Membrane protein, integral; Membrane protein, multi-pass Q13507 7222 4q27 human Y299-p 458805 KGLASPAyLSLSSED activity, induced 16407161 1 0 0 -Cd28 CD28 Cell surface; Membrane protein, integral P31041 12487 1 C2|1 30.52 cM mouse Y207-p 450284 TRKPYQPyAPARDFA activity, induced; molecular association, regulation Lck(INDUCES) 27460989; 9973466 7 8 276 Y207F mutation severely impaired the ability of CD28 to deliver a co-stimulus for the expression of CD69 and production of IL-2. -INSR INSR EC 2.7.10.1; KINASE; Kinase, protein; Membrane protein, integral; Protein kinase, TK; Protein kinase, tyrosine (receptor) P06213 3643 19p13.2 human S1062-p 451562 AVKTVNEsASLRERI PK_Tyr_Ser-Thr phosphorylation 10819237 3 0 1 alanine mutations of S1033, S1062, and S1064 increases tyrosine autophosphorylation of InsR -Pln PLB Inhibitor; Membrane protein, integral P61014 18821 10|10 B3 mouse K3-ub 27204320 _____MEkVQYLTRS Phospholamban ubiquitination 26966065 1 1 0 -TAOK2 TAO2 Apoptosis; EC 2.7.11.1; KINASE; Kinase, protein; Membrane protein, integral; Membrane protein, multi-pass; Protein kinase, STE; Protein kinase, Ser/Thr (non-receptor) Q9UL54 9344 16p11.2 human T468-p 23150863 RNRDHFAtIRTASLV cytoskeletal reorganization 25456499 1 1 1 spine development -YBX1 YB-1 RNA processing; RNA splicing; RNA-binding; Transcription factor P67809 4904 1p34.2 human S102-p 455636 NPRKYLRsVGDGETV CSD activity, induced; molecular association, regulation; protein stabilization; ubiquitination; intracellular localization carcinogenesis, induced; carcinogenesis, altered; cell motility, induced; transcription, induced; signaling pathway regulation; transcription, altered; translation, altered; cell growth, induced; cytoskeletal reorganization; translation, induced; transcription, inhibited; cell growth, altered KLF5(INDUCES) 15806160; 17704806; 19036157; 20844753; 21423216; 27591085; 31387591; 31906126; 32028981; 33379356; 33911076; 34272387; 35008856; 35022570; 35917517 23 33 2 -NFATC4 NFAT3 DNA-binding; Transcription factor Q14934 4776 14q12 human S168-p 448859 QGGGAFFsPSPGSSS intracellular localization; activity, inhibited cell differentiation, altered; transcription, altered; cell growth, altered 11997522; 17213202 7 0 1 -MDM2 MDM2 EC 6.3.2.-; EC 6.3.2.19; Inhibitor; Ligase; NEDDYLATION LIGASE; Neddylation Ligase; Nucleolus; Oncoprotein; UBIQUITIN LIGASE; Ubiquitin conjugating system; Ubiquitin ligase Q00987 4193 12q15 human S186-p 448131 RQRKRHKsDSISLSF activity, induced; protein degradation; protein stabilization; molecular association, regulation; ubiquitination; intracellular localization apoptosis, altered; signaling pathway regulation ER-beta(INDUCES); p300(INDUCES); ARF1(INDUCES); AR(INDUCES); CBP(INDUCES) 11504915; 11715018; 11923280; 18467333; 22349818; 22525275; 23132866; 28196907 14 9 2 -CTTN Cortactin Actin-binding; Cytoskeletal; Motility/polarity/chemotaxis Q14247 2017 11q13.3 human K309-ac 461724 YSKGFGGkYGVQKDR HS1_rep molecular association, regulation; intracellular localization cell motility, inhibited ACTB(DISRUPTS) 17643370 2 4 20 Acetylation prevents localization to membrane ruf?es. -PDE4D PDE4D iso5 EC 3.1.4.53; Nucleotide Metabolism - purine; Phosphodiesterase Q08499-5 5144 5q11.2-q12.1 human S413-p 451090 YQSTIPQsPSPAPDD enzymatic activity, inhibited 10828059 7 3 0 -PIN1 PIN1 EC 5.2.1.8; Isomerase; Nuclear receptor co-regulator Q13526 5300 19p13.2 human S71-p 18710000 HSQSRRPsSWRQEKI Rotamase protein degradation; molecular association, regulation; ubiquitination; intracellular localization; enzymatic activity, inhibited; activity, inhibited cell cycle regulation; carcinogenesis, inhibited; cell motility, inhibited; transcription, inhibited CPEB(INDUCES) 21497122; 23090969; 26387736 6 1 0 Pin1 induces CPEB ubiquitination and degradation. ; inhibits nuclear localization and centrosome amplification -Nudt14 NUDT14 EC 3.6.1.45; Hydrolase Q9D142 66174 12|12 F1 mouse T141-p 41294000 TDLRRVAtYMSGVGL NUDIX enzymatic activity, induced 26048992 1 0 0 -Tiam1 TIAM1 GEF; GEF, Rac/Rho; Motility/polarity/chemotaxis; Oncoprotein Q60610 21844 16 C3.3|16 51.5 cM mouse S172-p 11485306 FKKKRSKsADIWRED molecular association, regulation 14-3-3 zeta(INDUCES) 19899799 2 4 0 -PRKAA1 AMPKA1 Autophagy; EC 2.7.11.1; EC 2.7.11.26; EC 2.7.11.27; EC 2.7.11.31; KINASE; Kinase, protein; Protein kinase, CAMK; Protein kinase, Ser/Thr (non-receptor) Q13131 5562 5p13.1 human S496-p 450431 ATPQRSGsVSNYRSC AdenylateSensor enzymatic activity, inhibited 27784766 19 46 55 -ZC3HC1 NIPA Cell cycle regulation; Ubiquitin conjugating system Q86WB0 51530 7q32.2 human S344-p 468306 GSEQAEKsPGPIVSR Rsm1 molecular association, regulation; intracellular localization cell growth, induced NPM-ALK(DISRUPTS) 31434245 1 66 16 -XRCC1 XRCC1 DNA repair, damage P18887 7515 19q13.31 human T523-p 451448 AGSTDENtDSEEHQE molecular association, regulation; intracellular localization PARP1(DISRUPTS); APTX(INDUCES); Pnk1(INDUCES) 15066279; 15367657; 25477519 4 5 3 -HIPK2 HIPK2 EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, CMGC; Protein kinase, Ser/Thr (non-receptor) Q9H2X6 28996 7q34 human K803-ub 3059905 TSTTSSRkSKQHQSS protein degradation 18536714 1 0 0 -Med1 MED1 Nuclear receptor co-regulator; Transcription, coactivator/corepressor Q925J9 19014 11 D|11 61.75 cM mouse T1459-p 449866 HSKSPAYtPQNVDSE transcription, induced 18339625 7 2 0 -Rprd1b RPRD1B Motility/polarity/chemotaxis Q9CSU0 70470 2|2 H1 mouse S145-p 10404515 KAAEEKKsLKRTFQQ molecular association, regulation cell cycle regulation; carcinogenesis, induced; cell growth, induced; transcription, induced; cytoskeletal reorganization AurB(INDUCES) 30518842 1 1 2 regulate the expression of cyclin B1 in gastric cancer -NFATC1 NFAT2 DNA-binding; Transcription factor O95644 4772 18q23 human T154-p 1869090801 SSKRSPStATLSLPS activity, induced carcinogenesis, induced; cell motility, induced; transcription, induced 31730483 1 1 0 multiple sites mutatnt -GRK2 GRK2 EC 2.7.11.15; KINASE; Kinase, protein; Protein kinase, AGC; Protein kinase, Ser/Thr (non-receptor) P25098 156 11q13.2 human K220-ub 573762722 TGKMYAMkCLDKKRI Pkinase acetylation; phosphorylation cell motility, induced; cell adhesion, induced; cytoskeletal reorganization 22193721 1 2 0 induces deacetylation of TUBA1A at K40 via HDAC6 phosphorylation -Btk Btk EC 2.7.10.2; KINASE; Kinase, protein; Protein kinase, TK; Protein kinase, tyrosine (non-receptor) P35991 12229 X E3|X 56.18 cM mouse S21-p 463806 SQQKKKTsPLNFKKR PH molecular association, regulation PIN1(INDUCES) 16644721 1 1 2 Interaction with Pin1 negatively regulates Btk expression. -Gja1 GJA1 Channel, misc.; Membrane protein, integral; Membrane protein, multi-pass; Motility/polarity/chemotaxis P23242 14609 10 B4|10 28.64 cM mouse S368-p 447813 QRPSSRAsSRASSRP protein degradation; protein stabilization; ubiquitination endocytosis, induced 24498049; 24612377 57 8 1 -SMAD7 SMAD7 DNA-binding; Transcription factor O15105 4092 18q21.1 human R57-m2 1881315000 AGGGGPGrAGCCLGK activity, induced; molecular association, regulation carcinogenesis, induced; cell growth, induced; transcription, induced; signaling pathway regulation gp130(INDUCES) 34026434 1 1 0 STAT3 activation, STAT3 signaling, PRMT5 promotes lung tumorigenesis -SLC12A1 NKCC2 Membrane protein, integral; Membrane protein, multi-pass; Transporter; Transporter, SLC family Q13621 6557 15q21.1 human S130-p 478420 GPKVNRPsLLEIHEQ AA_permease_N activity, induced signaling pathway regulation 21321328 8 2 0 WNK-SPAK-OSR1 pathway -MAPT Tau iso8 ACETYLTRANSFERASE; Acetyltransferase; Cytoskeletal P10636-8 4137 17q21.31 human S262-p 447930 NVKSKIGsTENLKHQ Tubulin-binding O-GlcNAc glycosylation; protein stabilization; molecular association, regulation; intracellular localization; protein conformation; phosphorylation apoptosis, altered; cell growth, inhibited; apoptosis, induced; autophagy, inhibited; transcription, induced; cytoskeletal reorganization TUBA1A(DISRUPTS); TUBA4A(DISRUPTS); Tau iso8(INDUCES); TUBB(DISRUPTS); TUBA1A(INDUCES) 10090741; 15190058; 15652175; 15664690; 17045592; 18424437; 19451179; 20159774; 20466736; 20663882; 21204788; 23001711; 24618580; 33710538; 33967735; 34936879; 36003083; 36004506; 7706316; 9735171 118 25 2 -MPZL1 PZR Adaptor/scaffold; Membrane protein, integral O95297 9019 1q24.2 human Y263-p 449521 NKSESVVyADIRKN_ molecular association, regulation cell adhesion, altered SHP-2(INDUCES) 11751924 1 57 1101 -Pfn2 profilin 2 Actin-binding; Motility/polarity/chemotaxis Q9EPC6 81531 2q26 rat S138-p 35541800 MAKYLRDsGF_____ Profilin cytoskeletal reorganization 21920940 2 0 0 S138A mutant enhances, and S138D mutant inhibits, neurite extension in PC12 cells -Th TH Amino Acid Metabolism - tyrosine; EC 1.14.16.2; Endoplasmic reticulum; Mitochondrial; Oxidoreductase; Vesicle P24529 21823 7 F5|7 88.06 cM mouse S19-p 448542 KGFRRAVsEQDTKQA TOH_N phosphorylation neural plasticity 20356833; 32358047 46 9 4 IRL790-induced neurotransmission; SNCA S129A mutant has higher PPP2CA activation inhibiting TH S19 phosphorylation. -HBP1 HBP1 DNA-binding; Transcription factor O60381 26959 7q22.3 human S402-p 455671 GFSKNCGsPGSSQLS protein stabilization 14612426 1 6 0 -ADRB2 ADRB2 GPCR, family 1; Membrane protein, integral; Membrane protein, multi-pass; Receptor, GPCR P07550 154 5q32 human S346-p 447911 LLCLRRSsLKAYGNG receptor desensitization, inhibited; receptor recycling, inhibited; receptor desensitization, altered; intracellular localization; receptor internalization, altered cytoskeletal reorganization 11146000; 11809767; 24003153; 27646272; 9461522 12 3 0 -NFKBIA IkB-alpha DNA-binding; Inhibitor P25963 4792 14q13.2 human S293-p 451525 EESYDTEsEFTEFTE protein degradation 10764587 3 0 0 -HNF4A HNF4 alpha DNA-binding; Nuclear receptor; Transcription factor P41235 3172 20q13.12 human S313-p 449926 GKIKRLRsQVQVSLE Hormone_recep protein degradation transcription, inhibited 12740371; 28196117 5 3 0 -HSP90AA1 HSP90A Chaperone; Heat shock protein P07900 3320 14q32.31 human K191-sm 31843000 TKVILHLkEDQTEYL HATPase_c molecular association, regulation AHSA1(INDUCES) 24462205 1 0 0 inhibits chaperone function -MAP3K11 MLK3 EC 2.7.11.25; KINASE; Kinase, protein; Protein kinase, Ser/Thr (non-receptor); Protein kinase, TKL Q16584 4296 11q13.1 human S758-p 448611 GTPGTPRsPPLGLIS molecular association, regulation BRAF(DISRUPTS) 29084209 3 14 0 oxidative stress-induced invasion of colon cancer cells; promotes MLK3-dependent B-Raf and ERK1/2 activation -CASR CaR GPCR, family 3; Membrane protein, integral; Membrane protein, multi-pass; Motility/polarity/chemotaxis; Receptor, GPCR P41180 846 3q13.33-q21.1 human S875-p 4782110 TIEEVRCsTAAHAFK activity, inhibited signaling pathway regulation 31189667 1 2 0 regulates Ca2+ sensitivity -Ctnnb1 CTNNB1 Actin-binding; Cell adhesion; Motility/polarity/chemotaxis; Nuclear receptor co-regulator; Oncoprotein; Transcription factor Q9WU82 84353 8q32 rat S33-p 447487 QQQSYLDsGIHSGAT protein degradation; intracellular localization; phosphorylation cytoskeletal reorganization 14985333; 17260019 112 3 2 -Plcg1 PLCG1 Carbohydrate Metabolism - inositol phosphate; EC 3.1.4.11; Motility/polarity/chemotaxis; Phospholipase P10686 25738 3q42 rat Y1253-p 448576 EGSFEARyQQPFEDF enzymatic activity, induced 1708307 12 19 85 Y1253F inhibited full activation. ; Y771F mutation completely blocked activation, while Y774F enhanced activation -POLH POLH DNA repair, damage; EC 2.7.7.7; Transferase Q9Y253 5429 6p21.1 human K486-sm 1877365915 SLESFFQkAAERQKV intracellular localization; enzymatic activity, inhibited 32350109 1 1 0 -Esr1 ER-alpha DNA-binding; Nuclear receptor; Transcription factor P19785 13982 10 A1|10 2.03 cM mouse S216-p 12127402 CKAFFKRsIQGHNDY zf-C4 molecular association, regulation cell motility, induced; apoptosis, inhibited; transcription, induced; transcription, inhibited CaR(INDUCES) DNA(INDUCES) 24386386; 26585153; 32193417; 32727504 8 1 0 -CSNK1E CK1E EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, CK1; Protein kinase, Ser/Thr (non-receptor) P49674 1454 22q13.1 human S389-p 482888 RGAPANVsSSDLTGR protein degradation transcription, altered 17525164 1 18 13 phaosphorylation induces degredation of mPer2 and expression of circadian clock genes. -MYH9 MYH9 Actin-binding; Motility/polarity/chemotaxis; Motor P35579 4627 22q12.3 human S1943-p 456730 RKGAGDGsDEEVDGK molecular association, regulation; intracellular localization cell cycle regulation; carcinogenesis, inhibited; cell adhesion, induced; cell motility, altered; cytoskeletal reorganization S100A4(DISRUPTS); Cas-L(INDUCES) 17567956; 18971378; 19826041; 21316371; 22123909; 28053086; 30087119; 30267961 14 118 916 -STK38 NDR1 EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, AGC; Protein kinase, Ser/Thr (non-receptor) Q15208 11329 6p21.31 human T444-p 460659 DWVFINYtYKRFEGL Pkinase_C molecular association, regulation; phosphorylation; enzymatic activity, induced cell cycle regulation; cytoskeletal reorganization MOB1A(INDUCES); CCND1(INDUCES); MOB1B(NOT_REPORTED) 12493777; 19836237; 22445341; 23897809; 26057687 7 2 1 reduction in dendritic branching and length ; lower level of T444 phosphorylation in mitosis; NDR1 Y31A and Y74A mutants showed highly decreased T444 phosphorylation and centrosome amplification. -Slc1a2 GLT1 Membrane protein, integral; Membrane protein, multi-pass; Transporter; Transporter, SLC family P31596 29482 3q32 rat K517-ub 3932336 HEDIEMTkTQSVYDD receptor internalization, induced; protein degradation 18805448 1 1 4 -Plk1 PLK1 EC 2.7.11.21; KINASE; Kinase, protein; Protein kinase, Other; Protein kinase, Ser/Thr (non-receptor) Q07832 18817 7 F2|7 65.52 cM mouse Y166-p 54066600 QIVLGCQyLHRNQVI Pkinase enzymatic activity, induced cell cycle regulation 26755576 1 0 0 -MYH10 MYH10 Motility/polarity/chemotaxis; Motor P35580 4628 17p13.1 human S1935-p 4730818 LRRGGPIsFSSSRSG molecular association, regulation; intracellular localization cytoskeletal reorganization MYH10(INDUCES); ACTA1(INDUCES) 25869664; 30655296 2 18 0 -GLI3 GLI3 C2H2-type zinc finger protein; Transcription factor P10071 2737 7p14.1 human K800-ub 6097710 LNPILPPkAPAVSPL protein processing 16705181 1 0 0 -PALLD palladin Cytoskeletal; Motility/polarity/chemotaxis Q8WX93 23022 4q32.3 human S808-p 22826102 PPPPPVFsPTAAFPV molecular association, regulation cell motility, inhibited Abl(DISRUPTS) 22216253 1 0 0 -Fos Fos DNA-binding; Motility/polarity/chemotaxis; Oncoprotein; Transcription factor P01101 14281 12 D2|12 39.7 cM mouse S32-p 470080 DSLSYYHsPADSFSS intracellular localization transcription, induced 34496234 4 0 0 -Nfatc1 NFAT2 iso4 DNA-binding; Transcription factor Q6P7T9 18018 18 E3|18 53.66 cM mouse S259-p 40512526 SWLGARGsRPTSPCN intracellular localization transcription, inhibited 32997697 5 3 0 -MRTFA MKL1 Oncoprotein; Transcription, coactivator/corepressor Q969V6 57591 22q13.1-q13.2 human K624-sm 2407400 GPPSVVVkQEALQPE transcription, inhibited 16098147 1 0 0 -PAK6 PAK6 EC 2.7.11.1; KINASE; Kinase, protein; Nuclear receptor co-regulator; Protein kinase, STE; Protein kinase, Ser/Thr (non-receptor) Q9NQU5 56924 15q15.1 human T326-p 29666306 SPLTTSDtSSPQKSL molecular association, regulation; enzymatic activity, induced carcinogenesis, induced; cell motility, induced AR(INDUCES) 24130878 1 2 0 promotion of cell motility and invasion -Drd1 DRD1 GPCR, family 1; Membrane protein, integral; Membrane protein, multi-pass; Receptor, GPCR P18901 24316 17p14 rat S421-p 30310300 EKLSPALsVILDYDT intracellular localization; enzymatic activity, induced signaling pathway regulation 24362306 2 0 0 induced ERK1/2 activation; inhibition of phosphorylation leads to induce locomotor hyperactivity -KCNIP3 calsenilin Calcium-binding; Transcription factor Q9Y2W7 30818 2q11.1 human K26-sm 25336512 LGHTPLSkKEGIKWQ intracellular localization transcription, inhibited 21070824 1 0 0 -MKNK1 Mnk1 iso2 EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, CAMK; Protein kinase, Ser/Thr (non-receptor); Translation Q9BUB5-2 8569 1p33 human S353-p 56790200 QVLQRNSsTMDLTLF activity, inhibited 28545025 2 1 0 -PTPRJ PTPRJ EC 3.1.3.48; Membrane protein, integral; Motility/polarity/chemotaxis; PHOSPHATASE; Receptor protein phosphatase, tyrosine Q12913 5795 11p11.2 human Y1320-p 15228667 NTTAMTIyENLAPVT molecular association, regulation; enzymatic activity, induced cell motility, induced Src(INDUCES) 22898603 2 1 1 -COPS5 COPS5 Adaptor/scaffold; DEUBIQUITINASE; EC 3.4.-.-; Nuclear receptor co-regulator; Protease; Transcription, coactivator/corepressor; Translation Q92905 10987 8q13.1 human S320-p 33365506 EAIHGLMsQVIKDKL CSN5_C protein stabilization 24710276 1 1 0 deubiquitinates and stabilizes PEA-15 -Cox4i1 COX4I1 EC 1.9.3.1; Energy Metabolism - oxidative phosphorylation; Membrane protein, integral; Mitochondrial; Oxidoreductase P19783 12857 8 E1|8 69.99 cM mouse S58-p 479944 HVTMLSAsQKALKEK COX4 molecular association, regulation; enzymatic activity, induced cell growth, induced 21641552 2 9 2 phosphorylation of this site prevents ATP binding -GRIA1 GluR1 Channel, calcium; Channel, ligand-gated; Membrane protein, integral; Membrane protein, multi-pass P42261 2890 5q33.2 human S836-p 467226 CYKSRSEsKRMKGFC molecular association, regulation; intracellular localization EPB41L1(INDUCES) 19503082 6 0 0 enhances receptor insertion into plasma membrane -Etv1 ETV1 DNA-binding; Oncoprotein; Transcription factor P41164 14009 12 A3|12 17.99 cM mouse T139-p 3059605 MRPSNPPtPSSTPVS ETS_PEA3_N activity, induced transcription, induced; signaling pathway regulation 22586091 2 0 0 -CDK9 CDK9 Cell cycle regulation; EC 2.7.11.22; EC 2.7.11.23; KINASE; Kinase, protein; Nuclear receptor co-regulator; Protein kinase, CMGC; Protein kinase, Ser/Thr (non-receptor) P50750 1025 9q34.11 human K48-ac 486372 TGQKVALkKVLMENE Pkinase enzymatic activity, inhibited cell cycle regulation; DNA repair, inhibited 23898190 2 1 0 -HTRA2 HTRA2 EC 3.4.21.108; Membrane protein, integral; Mitochondrial; Protease O43464 27429 2p13.1 human S142-p 487466 VPSPPPAsPRSQYNF Peptidase_M50 enzymatic activity, induced carcinogenesis, inhibited; cytoskeletal reorganization 17906618; 24662565 4 0 1 phosphorylation of this site activates beta actin cleavage and decreases F actin presence in the cytosol -Hmga1 HMGA1 DNA-binding Q8K585 117062 20p12 rat T53-p 451515 KEPSEVPtPKRPRGR molecular association, regulation DNA(DISRUPTS) 10617144 4 55 35 -Eps8 EPS8 Adaptor/scaffold Q08509 13860 6 G1|6 66.78 cM mouse Y534-p 63063500 VKTQPKKyAKSKYDF phosphorylation carcinogenesis, induced; cell motility, induced; cell growth, induced; cell adhesion, induced 28214294 1 1 0 enhanced phosphorylation of ERK and FAK, increased cell adhesion and anchorage-dependent colony formation -RUNX1 AML1 DNA-binding; Oncoprotein; Transcription factor Q01196 861 21q22.12 human K182-ub 15384404 EPRRHRQkLDDQTKP protein degradation; intracellular localization carcinogenesis, inhibited; cell growth, inhibited; transcription, inhibited 28536267 1 3 1 -NR3C2 MCR DNA-binding; Nuclear receptor P08235 4306 4q31.23 human K494-sm 3144809 SGFPVGIkQEPDDGS transcription, induced; transcription, inhibited 14500761; 17105732 3 1 0 Ubc9 can be a transcriptional mineralocorticoid receptor coactivator. -PPP1R1A PPP1R1A Inhibitor; Protein phosphatase, regulatory subunit P01099 rabbit T35-p 447759 QIRRRRPtPATLVLT DARPP-32 molecular association, regulation; enzymatic activity, inhibited PPP1CA(INDUCES) 29311589 14 4 0 PKA-thiophosphorylated form of inhibitor-1 displays a different affnity to native and recombinant enzyme -SLC1A2 GLT1 Membrane protein, integral; Membrane protein, multi-pass; Transporter; Transporter, SLC family P43004 6506 11p13 human K551-ub 4667700 SVIVDECkVTLAANG molecular association, regulation GLT1(INDUCES) 35938532 2 0 0 formation of oligomers, epileptic seizures inhibited by APAP treatment -FMR1 FMR1 Nucleolus; RNA-binding; Translation Q06787 2332 Xq27.3 human S511-p 14323700 SDHRDELsDWSLAPT FXMRP1_C_core intracellular localization 20417602 4 1 0 -CASP6 CASP6 Apoptosis; EC 3.4.22.59; Protease P55212 839 4q25 human S257-p 452136 TLVNRKVsQRRVDFC Peptidase_C14 molecular association, regulation; enzymatic activity, inhibited; protein conformation apoptosis, inhibited Other(DISRUPTS) 22433863; 22483120 3 0 0 prevents binding to VEID-CHO and z-VAD-FMK; S257E mutation inhibits CASP6 self-activation in vitro -Rela NFkB-p65 DNA-binding; Nuclear receptor co-regulator; Transcription factor Q7TQN4 309165 1q43 rat S528-p 447799 SGLPNGLsGDEDFSS autophagy, induced 37237886 27 3 1 -DGCR8 DGCR8 Nucleolus; RNA processing; RNA-binding Q8WYQ5 54487 22q11.21 human S373-p 4777519 QSSDLTPsGDVSPVK protein stabilization 24239349 1 23 0 -KIF4A KIF4A Microtubule-binding; Motor O95239 24137 Xq13.1 human S801-p 459849 KLRRRTFsLTEVRGQ intracellular localization cell cycle regulation 28992084; 31881080 3 48 98 -POLL POLL DNA repair, damage; EC 2.7.7.7; Lyase; Transferase Q9UGP5 27343 10q24.32 human T553-p 5312301 GPGRVLPtPTEKDVF DNA_pol_B_thumb protein stabilization; ubiquitination 18688254 1 0 0 prevents POLL ubiquitination -DOCK1 DOCK1 Adaptor/scaffold; Cytoskeletal; GEF; GEF, Rac/Rho; Motility/polarity/chemotaxis Q14185 1793 10q26.2 human S1250-p 28698600 HAKLLKWsEDVCVAH DHR-2_Lobe_A molecular association, regulation carcinogenesis, induced; cell motility, induced; cell growth, induced; signaling pathway regulation RAC1(INDUCES) 23728337; 25468898 2 0 0 plays a role in EGFR-based glioblastoma carcinogenesis; PDGFRA initiated signaling-Rac1-Akt, ERK1/2 -CAV1 caveolin-1 Adaptor/scaffold; Motility/polarity/chemotaxis; Nuclear receptor co-regulator Q03135 857 7q31.2 human K47-ub 21171000 QVYDAHTkEIDLVNR Caveolin molecular association, regulation; intracellular localization UBXN6(INDUCES); VCP(INDUCES) 23335559 1 7 0 CAV1 ubiquitylation and binding to the VCP-UBXD1 complex and sorting into lysosomes -Sirt1 SIRT1 Apoptosis; DEACETYLASE; Deacetylase; EC 3.5.1.-; Nuclear receptor co-regulator NP_001401888 309757 20p11 rat K725-sm 1968605 VNEAIAMkQELTDVN sumoylation; molecular association, regulation autophagy, inhibited SUMO1(DISRUPTS); FAT10(DISRUPTS) 33307094 2 1 0 FAT10 regulates autophagy as a cardiac protector; FAT10 inhibits autophagy by inhibiting SIRT1 SUMOYylation -ADAR ADAR EC 3.5.4.37; Hydrolase; Nucleolus; RNA processing; RNA-binding P55265 103 1q21.3 human K576-ub 59149207 LLEEAKAkDSGKSEE protein degradation 27729454 1 0 0 regulation of IFN-signaling induced anti-viral activity -XRCC1 XRCC1 DNA repair, damage P18887 7515 19q13.31 human S409-p 3181462 LMAGPGSsSEEDEAS molecular association, regulation PARP1(DISRUPTS) 25477519 2 5 0 -MYBL2 B-Myb DNA-binding; Motility/polarity/chemotaxis; Transcription factor P10244 4605 20q13.12 human Y15-p 25284053 EDLDELHyQDTDSDV protein stabilization; molecular association, regulation VHL(DISRUPTS) 27090638 1 0 1 -Ctnnd1 CTNND1 Actin-binding; Adaptor/scaffold; Cell adhesion; G protein regulator, misc.; Motility/polarity/chemotaxis P30999 12388 2 D|2 49.45 cM mouse Y217-p 449647 PDGYGRHyEDGYPGG molecular association, regulation CDH1(INDUCES); RHOA(INDUCES) 17194753 2 13 102 -RAD17 RAD17 Cell cycle regulation O75943 5884 5q13.2 human S367-p 23136922 LKSDAVLsKSKRRKK molecular association, regulation RAD1(INDUCES) 29902452 1 0 1 -Npr1 ANPA EC 4.6.1.2; Guanylyl cyclase; KINASE; Kinase, protein; Lyase; Membrane protein, integral; Nucleotide Metabolism - purine; Protein kinase, RGC; Protein kinase, dual-specificity (receptor); Receptor, misc. P18910 24603 2q34 rat S515-p 14364503 WEDLQPSsLERHLRS receptor desensitization, altered; enzymatic activity, inhibited; protein conformation 20456499; 20977274 2 2 0 -Pick1 PICK1 Adaptor/scaffold; Cell development/differentiation; Ligand, receptor tyrosine kinase Q9EP80 84591 7q34 rat T82-p 14146800 GRSIKGKtKVEVAKM PDZ molecular association, regulation GluR2(DISRUPTS) 20403402 1 0 0 disrupts GluR2 clustering -DGKA DGKA EC 2.7.1.107; Kinase, lipid; Lipid Metabolism - glycerolipid; Lipid Metabolism - glycerophospholipid; Motility/polarity/chemotaxis P23743 1606 12q13.2 human Y335-p 486452 ILPPSSIyPSVLASG intracellular localization; enzymatic activity, induced carcinogenesis, induced; cell growth, induced; cell motility, altered 15773894; 17700527; 18424699; 35962191 5 0 0 -NELFE RDBP Mitochondrial; Transcription, coactivator/corepressor P18615 7936 6p21.33 human S251-p 468611 GPFRRSDsFPERRAP molecular association, regulation transcription, induced 14-3-3 epsilon(INDUCES) 29523821 1 26 2 dissociation of the NELF complex from chromatin, which is accompanied by RNA polymerase II elongation -DDX3X DDX3 Cell cycle regulation; EC 3.6.4.13; Helicase; RNA-binding; Spliceosome; Translation initiation O00571 1654 Xp11.4 human K118-ac 461737 GDRSGFGkFERGGNS transcription, induced 34158847 1 2 14 malonylation on lysine 66, 130 and 62 inhibits transcription -VHL VHL Tumor suppressor; UBIQUITIN LIGASE; Ubiquitin ligase P40337 7428 3p25.3 human S33-p 15573201 EEDGGEEsGAEESGP protein degradation transcription, altered 20637892; 26973240 2 0 0 VHL clevaage and subsequent degradation; regulates p53 activity and degradation of HIF1A -ZRANB1 ZRANB1 DEUBIQUITINASE; EC 3.4.19.12; Ligase; Protease; Ubiquitin conjugating system; Ubiquitin-specific protease Q9UGI0 54764 10q26.13 human S209-p 23077543 RWRGSCSsGNSQRRS activity, induced signaling pathway regulation 30686098 1 1 2 -Dnajc5 DNAJC5 Vesicle P60905 79130 3q43 rat S10-p 448129 DQRQRSLsTSGESLY neural plasticity STX1A(DISRUPTS) 11604405; 35543445 7 80 344 -Mapk8ip1 JIP1 Adaptor/scaffold Q9WVI9 19099 2|2 E1 mouse T201-p 449954 PLKTGEQtPPHEHIC ubiquitination; phosphorylation cell growth, induced 35581583 2 1 0 induces Itch phosphorylation and Notch1 ubiquitination -Irs1 IRS1 Adaptor/scaffold; Motility/polarity/chemotaxis P35570 25467 9q34 rat S302-p 450190 TRRSRTEsITATSPA phosphorylation 36207218 56 12 1 inhibits phosphorylation of PI3K, AKT, and eNOS -App APP iso2 Apoptosis; Cell surface; Membrane protein, integral; Receptor, misc.; Transcription factor P12023-2 11820 16 C3.3|16 46.92 cM mouse S655-p 448200 LKKKQYTsIHHGVVE APP_amyloid molecular association, regulation; protein processing BACE(INDUCES) 31287605 6 1 0 amyloidogenic processing -CDKN1A p21Cip1 Cell cycle regulation; Inhibitor P38936 1026 6p21.2 human K75-ub 9897000 VRGLGLPkLYLPTGP protein degradation; ubiquitination 13678583; 17429006 4 6 4 under chelated Fe2+ conditions p21Cip1 is degraded by ubiquitin independent proteasomal degradation.; UV-induced -Fcer1g FCER1G Membrane protein, integral; Receptor, misc. P20491 14127 1 H3|1 79.23 cM mouse Y65-p 451737 REKADAVyTGLNTRS ITAM molecular association, regulation endocytosis, induced Cbl-b(DISRUPTS) 27428899 4 15 593 -BAG3 BAG3 Apoptosis; Chaperone O95817 9531 10q26.11 human S377-p 452222 PVPCPPPsPGPSAVP protein degradation; molecular association, regulation; ubiquitination cell cycle regulation; carcinogenesis, inhibited; cell growth, inhibited; apoptosis, induced; cell motility, inhibited FBXO22(INDUCES) 34215846 3 44 16 -FH fumarase Carbohydrate Metabolism - citrate (TCA) cycle; EC 4.2.1.2; Lyase; Mitochondrial; Tumor suppressor P07954 2271 1q43 human T90-p 3823351 GVTERMPtPVIKAFG Lyase_1 molecular association, regulation carcinogenesis, inhibited; cell growth, inhibited; transcription, induced; signaling pathway regulation p53(INDUCES); RBPJ(INDUCES) 30683654 1 9 3 Notch signaling; induces transcription of p21 -Nr1d1 NR1D1 Nuclear receptor; Transcription factor Q3UV55 217166 11|11 D mouse T275-p 55578702 SQFPQQLtPPRSPSP protein degradation 27238018 1 0 0 modulate amplitude of circadian clock -EGR1 EGR1 C2H2-type zinc finger protein; DNA-binding; Transcription factor P18146 1958 5q31.2 human S301-p 11423702 AFATQSGsQDLKALN protein stabilization transcription, induced; transcription, altered DNA(DISRUPTS) 34562454; 8662759 2 1 0 -DYNLL2 DYNLL2 Microtubule-binding; Motility/polarity/chemotaxis; Motor Q96FJ2 140735 17q22 human S88-p 18610003 VAILLFKsG______ Dynein_light molecular association, regulation BMF(DISRUPTS); MYO5A(DISRUPTS) 20889982 1 0 0 -Ern1 IRE1 Apoptosis; Chaperone; EC 2.7.11.1; Endoplasmic reticulum; KINASE; Kinase, protein; Membrane protein, integral; Protein kinase, Other; Protein kinase, Ser/Thr (non-receptor); Ribonuclease Q9EQY0 78943 11|11 E1 mouse S729-p 53407300 RHSFSRRsGVPGTEG Pkinase RNA splicing, induced 29511123 2 2 0 expression of spliced XBP1; RE1-dependent decay (RIDD) of other mRNAs -Btk Btk EC 2.7.10.2; KINASE; Kinase, protein; Protein kinase, TK; Protein kinase, tyrosine (non-receptor) P35991 12229 X E3|X 56.18 cM mouse Y223-p 447485 LKKVVALyDYMPMNA SH3_1 molecular association, regulation; palmitoylation; enzymatic activity, induced carcinogenesis, induced; apoptosis, inhibited; signaling pathway regulation; cell growth, altered GTF2I(INDUCES) 34582250; 36160379; 9012831; 9391111 41 14 250 PI 3-kinase is required for BTK activation and transformation. -FSCN1 fascin Actin-binding; Cytoskeletal; Motility/polarity/chemotaxis Q16658 6624 7p22.1 human K353-ub 60122801 TLRASNGkFVTSKKN Fascin cytoskeletal reorganization 27879315 1 1 0 fascin bundling activity -TNKS TNKS EC 2.4.2.30; Transferase O95271 8658 8p23.1 human T930-p 21326700 LAHGADPtMKNQEGQ Ank_5 protein stabilization; intracellular localization; enzymatic activity, induced cell cycle regulation; cell growth, induced 21818122 1 0 1 -ATG16L1 ATG16L1 iso2 Adaptor/scaffold; Autophagy; Membrane protein, peripheral Q676U5-2 55054 2q37.1 human S268-p 3202215 SRAATRRsVSSFPVP protein degradation autophagy, inhibited 31580256 3 32 0 -OPRD1 DOR-1 GPCR, family 1; Membrane protein, integral; Membrane protein, multi-pass; Receptor, GPCR P41143 4985 1p35.3 human T361-p 448551 RERVTACtPSDGPGG receptor inactivation, induced; receptor internalization, induced 32444688 4 1 0 -ADAR ADAR EC 3.5.4.37; Hydrolase; Nucleolus; RNA processing; RNA-binding P55265 103 1q21.3 human K418-sm 3726902 NGQEPVIkLENRQEA enzymatic activity, inhibited 16120648 1 5 0 -HABP4 HABP4 Transcription regulation Q5JVS0 22927 9q22.32 human K213-sm 1873147500 DAFDQRGkREFERYG HABP4_PAI-RBP1 molecular association, regulation 28695742 1 0 0 Presence of SUMO-1 strongly influences the interaction of HABP4 (Ki-1/57) with other cellular proteins.; Fewer PML-nuclear bodies when compared to non-SUMOylated triple mutants, but not when treated with As2O2 -EGFR EGFR EC 2.7.10.1; KINASE; Kinase, protein; Membrane protein, integral; Oncoprotein; Protein kinase, TK; Protein kinase, tyrosine (receptor) P00533 1956 7p11.2 human K714-ub 1065307 LKETEFKkIKVLGSG PK_Tyr_Ser-Thr receptor recycling, inhibited; protein degradation 16543144; 17940017 2 2 0 -YAP1 YAP1 Oncoprotein; Transcription, coactivator/corepressor P46937 10413 11q22.1 human T241-gl 93432001 DGWEQAMtQDGEIYY WW protein stabilization; molecular association, regulation; phosphorylation carcinogenesis, induced; cell growth, induced LATS1(DISRUPTS) 28474680 1 0 0 inhibits phosphorylation at S127 -Ctnnd1 CTNND1 iso3 Actin-binding; Adaptor/scaffold; Cell adhesion; G protein regulator, misc.; Motility/polarity/chemotaxis P30999-3 12388 2 D|2 49.45 cM mouse Y257-p 450397 APSRQDVyGPQPQVR cell cycle regulation; cell motility, altered 18515860 2 27 754 -XRCC4 XRCC4 DNA repair, damage Q13426 7518 5q14.2 human T233-p 2286405 DPVYDEStDEESENQ XRCC4 molecular association, regulation APLF(INDUCES); Pnk1(INDUCES) 18077224; 20852255 2 9 0 -Zeb1 TCF8 C2H2-type zinc finger protein; DNA-binding; Motility/polarity/chemotaxis; Transcription, coactivator/corepressor Q62947 25705 17q12.1 rat T867-p 469215 DQNDSDCtPPKKKTR intracellular localization transcription, induced 26868487 1 0 5 disrrupts nuclear localization -Hif3a HIF3A iso2 Transcription factor; Tumor suppressor Q0VBL6-2 53417 7|7 A2 mouse S184-p 291887100 HFSLRMKsTLTSRGR apoptosis, induced 29054108 1 1 0 mitochondrial clustering -HOXB13 HOXB13 DNA-binding; Transcription factor Q92826 10481 17q21.32 human S31-p 1883583910 GRNLVAHsPLTSHPA protein degradation; molecular association, regulation; ubiquitination; intracellular localization carcinogenesis, induced; cell growth, induced; transcription, altered SKP2(INDUCES) 37409967 1 0 0 induces nuclear translocation of NFKB -AKAP8 AKAP8 Adaptor/scaffold; Cell cycle regulation; Mitochondrial; RNA-binding O43823 10270 19p13.12 human Y154-p 476956 RPSYSYDyEFDLGSD molecular association, regulation 25770215 1 0 1 Phenylalanine mutants inhibited dissociation from nuclear structures; structural chromatin changes -SFN 14-3-3 sigma Adaptor/scaffold P31947 2810 1p36.11 human Y130-p 38485859 MKGDYYRyLAEVATG 14-3-3 molecular association, regulation SKP1A(INDUCES) 30728155 1 0 0 -EIF4A3 DDX48 EC 3.6.4.13; Helicase; RNA splicing; RNA-binding; Spliceosome P38919 9775 17q25.3 human T163-p 3190132 GQHVVAGtPGRVFDM DEAD molecular association, regulation; intracellular localization cell cycle regulation; RNA splicing, inhibited; RNA stability, induced; cytoskeletal reorganization; translation, induced NCM(INDUCES) RNA(DISRUPTS) 30784594 2 27 1 inhibits mRNA decay (NMD); T163 phosphorylation triggers/induces exon junction complex( EJC) remodeling -RBL2 Rb-like 2 Transcription, coactivator/corepressor; Tumor suppressor Q08999 5934 16q12.2 human S672-p 448254 TLYDRYSsPPASTTR protein degradation; molecular association, regulation cell cycle regulation; transcription, induced SKP2(INDUCES); E2F4(DISRUPTS); LIN9(DISRUPTS); DKFZp686L1814(DISRUPTS) 11157749; 12006580; 12435635; 28289097; 35235778 6 4 7 -Rigi RIGI EC 3.6.4.13; Hydrolase Q6Q899 230073 4|4 A5 mouse K18-m1 1883825700 AFRDYIKkILDPTYI CARD_2 molecular association, regulation carcinogenesis, induced; signaling pathway regulation AMPKA1(INDUCES); STAT3(DISRUPTS) 36333807 1 1 0 RIGI demethylation inhibited IL-6-STAT3 signaling; demethylation of RIG-I to enhances RIGI-STAT3 association; JMJD4 and RIGI co-operatively inhibit DEN-induced hepatocarcinogenesis and steatosis; methylated RIG-I associates with AMPKA1 to inhibit HMGCR phosphorylation and promote cholesterol synthesis and NAFLD progression -ETAA1 ETAA16 Cell surface Q9NY74 54465 2p14 human S95-p 1869465805 SLSSSFSsPNDPDGQ ETAA1 cell cycle regulation; signaling pathway regulation 31615875 1 0 0 critical for chromosome stability -TP53 p53 Activator; DNA-binding; Motility/polarity/chemotaxis; Nuclear receptor co-regulator; Transcription factor; Tumor suppressor P04637 7157 17p13.1 human S367-p 1881548604 GGSRAHSsHLKSKKG protein degradation; molecular association, regulation; ubiquitination; intracellular localization cell cycle regulation; cell growth, induced; apoptosis, inhibited; transcription, inhibited DNA(DISRUPTS) 37041410 1 1 0 -Traf6 TRAF6 EC 6.3.2.-; Ligase; UBIQUITIN LIGASE; Ubiquitin conjugating system; Ubiquitin ligase P70196 22034 2|2 E2 mouse S13-p 25757009 CENSCGSsQSSSDCC intracellular localization 27818144 1 0 1 nuclear localization -CIITA CIITA DNA-binding; EC 2.7.11.1; KINASE; Protein kinase, Ser/Thr (non-receptor); Transcription, coactivator/corepressor P33076 4261 16p13.13 human S293-p 2902203 STSPFAPsATDLPSM intracellular localization transcription, altered 15210796 1 0 0 -RICTOR RICTOR Adaptor/scaffold; Cell cycle regulation; Ubiquitin conjugating system Q6R327 253260 5p13.1 human K1119-ac 41692102 SSDPKGGkLSSESKT RICTOR_phospho signaling pathway regulation 26170313 1 0 0 induces mTORC2 signaling -Septin5 SEPT5 Cell cycle regulation; Cytoskeletal; Hydrolase; Vesicle Q9JJM9 116728 11q23 rat S161-p 2753800 HCCLYFIsPFGHGLR Septin molecular association, regulation exocytosis, altered STX1A(DISRUPTS) 18385322 1 0 0 -COL17A1 COL17A1 Extracellular matrix; Membrane protein, integral; Motility/polarity/chemotaxis Q9UMD9 1308 10q25.1 human S544-p 484007 KIGLHSDsQEELWMF cell adhesion, altered 17545155 1 0 0 regulates COL17A1 shedding of ectodomain -SET SET iso2 Apoptosis; DNA replication; DNA-binding; Inhibitor; Nuclear receptor co-regulator; Oncoprotein; Protein phosphatase, regulatory subunit Q01105-2 6418 9q34.11 human S171-p 27425001 KDLTKRSsQTQNKAS NAP molecular association, regulation; phosphorylation; enzymatic activity, induced signaling pathway regulation SET iso2(DISRUPTS) 23251465; 30917007 2 0 0 -FLCN FLCN Tumor suppressor Q8NFG4 201163 17p11.2 human S571-p 31085315 HLMSTVRsPTASESR intracellular localization; phosphorylation cell cycle regulation; carcinogenesis, induced; signaling pathway regulation 31395606 1 5 0 induces localization of mTORC1, increases phosphorylation of mTORC1 targets, regulates mTORC1 pathway -TICAM1 TICAM1 Adaptor/scaffold; Apoptosis Q8IUC6 148022 19p13.3 human S210-p 31858079 LASNLEIsQSPTMPF molecular association, regulation; phosphorylation IRF3(INDUCES) 25636800 1 1 0 induces IFN production -SQLE SQLE EC 1.14.13.132; Endoplasmic reticulum; Lipid Metabolism - steroid biosynthesis; Membrane protein, integral; Membrane protein, multi-pass; Oxidoreductase Q14534 6713 8q24.13 human S83-ub 1879784804 IGFFWAKsPPESENK protein degradation 30940729 1 1 0 cholesterol-accelerated degradation -GRK2 GRK2 EC 2.7.11.15; KINASE; Kinase, protein; Protein kinase, AGC; Protein kinase, Ser/Thr (non-receptor) P25098 156 11q13.2 human Y86-p 447727 ARPLVEFyEEIKKYE RGS protein degradation; molecular association, regulation G-alpha(q)(INDUCES) 11566877; 16725308 5 0 0 -MATR3 matrin 3 RNA processing; RNA-binding P43243 9782 5q31.2 human T150-p 1218501 LQLKRRRtEEGPTLS intracellular localization 20962082 2 20 50 -PLIN3 perilipin 3 Vesicle O60664 10226 19p13.3 human Y251-p 1873650102 ERLRQHAyEHSLGKL Perilipin protein degradation; molecular association, regulation autophagy, induced; cell growth, induced; apoptosis, inhibited HSC70(INDUCES) 34077757 1 1 0 -CDKN1B p27Kip1 Cell cycle regulation; Inhibitor; Oncoprotein; Protein kinase, regulatory subunit P46527 1027 12p13.1 human Y88-p 456818 KGSLPEFyYRPPRPP protein degradation; molecular association, regulation; ubiquitination; intracellular localization; protein conformation; activity, inhibited; phosphorylation cell cycle regulation; carcinogenesis, induced; cell growth, induced SKP2(INDUCES); CDK2(INDUCES); CDK4(DISRUPTS); CDK2(DISRUPTS); CDK4(INDUCES) 16195327; 17254966; 17908796; 21423214; 21423803; 22276948; 33147476; 35247157; 37443738 14 0 0 -Notch3 NOTCH3 Membrane protein, integral Q61982 18131 17 B1|17 17.37 cM mouse S1673-p 11179168 ARRKREHsTLWFPEG protein stabilization; molecular association, regulation; intracellular localization carcinogenesis, induced; transcription, inhibited CSL(DISRUPTS) 33775697 1 1 1 -APOBEC3G APOBEC3G EC 3.5.4.-; Hydrolase; RNA processing; RNA-binding Q9HC16 60489 22q13.1 human T218-p 21656100 WVRGRHEtYLCYEVE NAD2 enzymatic activity, inhibited 21659520 2 0 0 -Glp1r GLP1R GPCR, family 2; Membrane protein, integral; Membrane protein, multi-pass; Receptor, GPCR P32301 25051 20p12 rat S452-p 451370 SGATVGSsVYAATCQ receptor desensitization, altered 8702711 1 0 0 -CSNK1A1 CK1A EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, CK1; Protein kinase, Ser/Thr (non-receptor) P48729 1452 5q32 human K179-ub 54227300 HIPYREDkNLTGTAR Pkinase protein degradation 26909574 1 1 0 -RUNX3 AML2 DNA-binding; Transcription factor Q13761 864 1p36.11 human S356-p 7705800 SSSGGDRsPTRMLAS RunxI protein degradation; ubiquitination transcription, altered 19351720 1 0 0 degradation by cyclin D1 -RAP1GAP2 RAP1GAP2 GAP; GAP, Ras Q684P5 23108 17p13.3 human S9-p 1319201 FGRKRSVsFGGFGWI molecular association, regulation 14-3-3 beta(INDUCES); 14-3-3 zeta(INDUCES) 18039662 1 10 10 14-3-3 binding attenuates Rap1GAP2 mediated inhibition of cell adhesion -HJURP HJURP Histone-binding; Nucleolus Q8NCD3 55355 2q37.1 human S210-p 27449204 GDPAKPAsSPREWDP molecular association, regulation cell cycle regulation 28017591 1 2 0 prevents premature CENP-A assembly -Map3k7 TAK1 iso3 EC 2.7.11.25; KINASE; Kinase, protein; Protein kinase, Ser/Thr (non-receptor); Protein kinase, TKL Q923A8 26409 4|4 A5 mouse S439-p 455196 NGQPRRRsIQDLTVT activity, induced; molecular association, regulation apoptosis, induced; signaling pathway regulation TAB2(INDUCES); TRAF6(INDUCES) 30626936 9 83 63 Phosphorylation of JNK, p38 and IkB (subsequent degradation) -FFAR4 GPR120 iso1 GPCR, family 1; Lipid-binding; Membrane protein, integral; Membrane protein, multi-pass; Receptor, GPCR Q5NUL3-1 338557 10q23.33 human S366-p 31014808 GAILTDTsVKRNDLS receptor internalization, induced; molecular association, regulation ARR3(INDUCES); ARRB1(INDUCES) 24412271; 24817122 5 1 0 -Gja1 GJA1 Channel, misc.; Membrane protein, integral; Membrane protein, multi-pass; Motility/polarity/chemotaxis P23242 14609 10 B4|10 28.64 cM mouse S279-p 448853 SSPTAPLsPMSPPGY activity, induced; receptor internalization, induced; protein degradation; ubiquitination; intracellular localization; phosphorylation cell growth, induced 22729691; 25952543; 29959233; 30872361; 30981509 42 6 1 -Stxbp5l STXBP5L Q5DQR4 207227 16 26.32 cM|16 B3 mouse K309-sm 31957313 ESCKPILkVEYKTCR LLGL neural plasticity 24614299 1 0 0 -Tab2 TAB2 Adaptor/scaffold Q99K90 68652 10|10 A1 mouse K562-sm 1877015600 KKKLDKLkSEVNEME molecular association, regulation transcription, inhibited; signaling pathway regulation 33184450 1 0 0 inhibition of TRAF6/TAB2/TAK1 complex and downstream MAPK and NF-?B pathway -HIVEP3 HIVEP3 C2H2-type zinc finger protein; Transcription, coactivator/corepressor Q5T1R4 59269 1p34.2 human T869-p 1874499602 EEPDRPDtEPEPPPK molecular association, regulation 14-3-3 beta(INDUCES); 14-3-3 sigma(INDUCES); 14-3-3 theta(INDUCES); 14-3-3 zeta(INDUCES); 14-3-3 epsilon(INDUCES); 14-3-3 gamma(INDUCES); 14-3-3 eta(INDUCES) 34341191 1 0 0 -STAT5A STAT5A DNA-binding; Motility/polarity/chemotaxis; Oncoprotein; Transcription factor P42229 6776 17q21.2 human T92-gl 5262510 IKLGHYAtQLQKTYD STAT_int molecular association, regulation transcription, induced CBP(INDUCES) 14597631 1 1 0 -EPOR EPOR Membrane protein, integral; Receptor, cytokine P19235 2057 19p13.2 human Y489-p 457448 DGPYSNPyENSLIPA apoptosis, inhibited 14662339 4 0 0 -NTRK1 TrkA EC 2.7.10.1; KINASE; Kinase, protein; Membrane protein, integral; Oncoprotein; Protein kinase, TK; Protein kinase, tyrosine (receptor) P04629 4914 1q23.1 human Y791-p 447765 LAQAPPVyLDVLG__ molecular association, regulation; enzymatic activity, induced apoptosis, induced; signaling pathway regulation; cell growth, altered PLCG1(INDUCES) 10617652; 35471943; 8155326; 8384556 9 0 2 regulates NGF-TrkA? and PLC-mediated pathways; regulate NGF induced neurite outgrowth and ERK activity -PRKCD PKCD EC 2.7.11.13; KINASE; Kinase, protein; Nuclear receptor co-regulator; Protein kinase, AGC; Protein kinase, Ser/Thr (non-receptor); Protein kinase, tyrosine (non-receptor); Tumor suppressor Q05655 5580 3p21.1 human T141-p 1028305 EDEAKFPtMNRRGAI enzymatic activity, induced 19366211 2 9 1 -DCX Doublecortin iso2 Cytoskeletal; Motility/polarity/chemotaxis O43602-2 1641 Xq23 human T321-p 451361 TSSSQLStPKSKQSP intracellular localization cell motility, altered; cytoskeletal reorganization 14765123 3 0 2 affects doublecortin localization to growth cones, neurite outgrowth, and neuronal motility -Llgl1 LLGL1 Cell adhesion; Cytoskeletal; Motility/polarity/chemotaxis Q80Y17 16897 11 B2|11 37.81 cM mouse S650-p 449914 LAMEGPLsRVKSLKK intracellular localization 11809830 1 0 0 -TP53 p53 Activator; DNA-binding; Motility/polarity/chemotaxis; Nuclear receptor co-regulator; Transcription factor; Tumor suppressor P04637 7157 17p13.1 human S33-p 447531 LPENNVLsPLPSQAM activity, induced; protein degradation; acetylation; protein stabilization; molecular association, regulation; ubiquitination; phosphorylation cell cycle regulation; carcinogenesis, induced; apoptosis, induced; transcription, induced; transcription, altered; DNA repair, induced; cell growth, induced; apoptosis, inhibited; cell growth, altered FBXW7(INDUCES); S100B(INDUCES); S100A1(INDUCES); S100A4(INDUCES); PIN1(INDUCES); CBP(INDUCES); S100A6(INDUCES); S100A2(INDUCES) DNA(INDUCES) 10581258; 11495913; 12397361; 12397362; 12860987; 14665630; 17906639; 17942552; 19251701; 19819244; 20962272; 21383696; 31940492; 35974003; 36923828; 9744860 35 3 0 -PXN PXN iso2 Adaptor/scaffold; Cell adhesion; Cytoskeletal; Motility/polarity/chemotaxis P49023-2 5829 12q24.23 human S178-p 448603 PPLPGALsPLYGVPE Paxillin protein stabilization; intracellular localization cytoskeletal reorganization; cell adhesion, altered 18818208 9 2 0 in response to E4orf4; Phosphorylated S178 recruits, retains, and stabilizes paxillin to focal adhesions. -PRMT8 PRMT8 EC 2.1.1.-; METHYLTRANSFERASE; Methyltransferase; Methyltransferase, protein arginine Q9NR22 56341 12p13.32 human R73-m2 2574938 NPEEMTSrDYYFDSY enzymatic activity, altered PRMT8(INDUCES) 17925405 1 1 0 automethylation -KLRF2 KLRF2 Membrane protein, integral D3W0D1 100431172 12p13.31 human Y7-p 62864300 _MENEDGyMTLSFKN activity, induced 28082678 1 0 0 -Sox2 SOX2 Cell development/differentiation; DNA-binding; Transcription factor P48432 20674 3 A3|3 16.93 cM mouse S39-p 18913847 TGGNQKNsPDRVKRP cell differentiation, inhibited 28584195 2 3 0 neuronal differentiation, neurogenic commitment during embryogenesis but only if S39 is dephosphorylated -KIF2C KIF2C Cancer Testis Antigen (CTA); Microtubule-binding; Motility/polarity/chemotaxis; Motor Q99661 11004 1p34.1 human S632-p 5829783 EELSSQMsSFNEAMT enzymatic activity, induced cell cycle regulation; cytoskeletal reorganization 25504441 1 2 1 1) Regulates catalytic activity of KIF2C 2) Activates KIF2C during mitosis. 3) Phosphorylation is required for microtubule depolymerization and proper spindle assembly. 4) Prevention of S632/S633 phosphorylation leads to chromosome segregation defects in anaphase. -Marcksl1 MLP Cell cycle regulation P28667 17357 4 D2.2|4 63.26 cM mouse S93-p 477961 PKKKKKFsFKKPFKL MARCKS intracellular localization cytoskeletal reorganization 21602810 1 17 75 -Sox9 SOX9 DNA-binding; Transcription factor Q04887 20682 11 E2|11 77.27 cM mouse S492-p 1877718900 PSIPQTHsPQHWEQP protein degradation; molecular association, regulation cell differentiation, inhibited; transcription, altered SMAD3(DISRUPTS) 35803931 1 1 0 -ADRB2 ADRB2 GPCR, family 1; Membrane protein, integral; Membrane protein, multi-pass; Receptor, GPCR P07550 154 5q32 human S364-p 458915 NGNTGEQsGYHVEQE molecular association, regulation; receptor desensitization, altered; receptor internalization, altered ARR3(INDUCES); ARRB2(INDUCES) 11040066; 16407241; 18801735; 22275358 5 0 0 -GRK2 GRK2 EC 2.7.11.15; KINASE; Kinase, protein; Protein kinase, AGC; Protein kinase, Ser/Thr (non-receptor) P25098 156 11q13.2 human K31-ub 573762708 PAARASKkILLPEPS protein degradation 17006543 1 2 0 -NBN NBS1 Cell cycle regulation; DNA repair, damage O60934 4683 8q21.3 human K715-ac 487516 LIAHHARkNTELEEW Nbs1_C phosphorylation cell cycle regulation; apoptosis, induced 17612497 2 1 0 inhibits phosphorylation at S343 -DRD2 DRD2 iso2 GPCR, family 1; Membrane protein, integral; Membrane protein, multi-pass; Receptor, GPCR P14416-2 1813 11q23.2 human T134-p 13315301 AISIDRYtAVAMPML 7tm_1 receptor desensitization, induced 23082996 2 0 0 PKC mediated receptor desensitization -LAT LAT Adaptor/scaffold; Membrane protein, integral O43561 27040 16p11.2 human Y161-p 447760 DDYHNPGyLVVLPDS LAT molecular association, regulation PLCG1(INDUCES) 10811803 24 1 1 -INVS INVS Q9Y283 27130 9q31.1 human T864-p 55578722 SGARRLEtSTLSEDF cytoskeletal reorganization 27220846 1 0 0 Akt2 plays a more prominent role in ciliary development than Akt1, tubular differentiation -PLD2 PLD2 EC 3.1.4.4; Lipid Metabolism - ether lipid; Lipid Metabolism - glycerophospholipid; Motility/polarity/chemotaxis; Phospholipase O14939 5338 17p13.2 human T252-p 456498 LLYMCLEtGAISFVQ enzymatic activity, induced 15979581 1 1 0 -Mff MFF Membrane protein, integral; Mitochondrial Q6PCP5 75734 1|1 C5 mouse S146-p 484865 GQLVRNDsIVTPSPP Miff molecular association, regulation carcinogenesis, inhibited; autophagy, induced; cell growth, inhibited; signaling pathway regulation DRP1(INDUCES) 31693892; 36481655 6 54 13 -SNRPB snRNP B1 RNA processing; RNA splicing; RNA-binding; Spliceosome P14678 6628 20p13 human R147-m2 476756 QVMTPQGrGTVAAAA molecular association, regulation SMN(INDUCES) 11720283 1 4 0 -PKM PKM Carbohydrate Metabolism - glycolysis and gluconeogenesis; Carbohydrate Metabolism - pyruvate; EC 2.7.1.40; KINASE; Kinase, other; Mitochondrial; Nucleotide Metabolism - purine P14618 5315 15q23 human Y148-p 454768 KITLDNAyMEKCDEN PK enzymatic activity, inhibited cell growth, induced 26759242 3 28 321 -NOVA2 NOVA2 Q9UNW9 4858 19q13.32 human S25-p 1869341901 EVVCTKRsNTGEEGE intracellular localization 32492405 1 1 0 Phosphorylated NOVA2 translocates to cytosol leading to reduced E29 inclusion in BK channel and thereby inhibiting BK channel activity. -HNRNPUL1 E1B-AP5 RNA splicing; RNA-binding Q9BUJ2 11100 19q13.2 human R639-m1 12191845 RGPPGGNrGGFQNRG molecular association, regulation; intracellular localization NBS1(INDUCES) 26020839 1 4 14 ecruitment at sites of damage -Dixdc1 DIXDC1 Cell adhesion; Cell development/differentiation Q80Y83 330938 9|9 A5.3 mouse S250-p 15714601 CSSLTSPsPIHSAKS molecular association, regulation cell motility, altered; cytoskeletal reorganization NDEL1(INDUCES) 20624590 1 4 0 DIXDC1/NDEL1/DISC1 complex -Caskin1 CASKIN1 Adaptor/scaffold Q8VHK2 140722 10q12 rat Y296-p 472784 TKDYCNNyDLTSLNV SH3_2 protein conformation 23181695 1 2 28 Phosphorylation leads to structural changes in the SH3 domain. -MAP3K7 TAK1 EC 2.7.11.25; KINASE; Kinase, protein; Protein kinase, Ser/Thr (non-receptor); Protein kinase, TKL O43318 6885 6q15 human S439-p 455196 NGQPRRRsIQDLTVT molecular association, regulation IKKG(INDUCES) 29511289 9 83 63 -Dpysl2 CRMP-2 Microtubule-binding; Motility/polarity/chemotaxis O08553 12934 14 D1|14 34.6 cM mouse K374-sm 31094501 DKAVVTGkMDENQFV Amidohydro_1 activity, induced; sumoylation; intracellular localization signaling pathway regulation 23510938; 23836888; 28277940; 34757807 6 0 0 decreases calcium influx, CRMP2/CaV2.2 signaling pathway; CRMP-2 K374A mutant or compound 194 decreased SUMOylation NaV1.7 currents in sensory neurons across species -MARCKS MARCKS Actin-binding; Motility/polarity/chemotaxis P12624 613548 cow S169-p 451837 SFKLSGFsFKKNKKE MARCKS exocytosis, induced 22013076 11 76 93 Calcium mobilization, degranulation induced and dissociation of MARCK5 from plasma membrane. -TEX14 TEX14 Cancer Testis Antigen (CTA); KINASE; Kinase, protein; Protein kinase, Other; Protein kinase, Ser/Thr (non-receptor) Q8IWB6 56155 17q22 human T727-p 25158903 SNLNNMStTEEYLIS molecular association, regulation; intracellular localization PLK1(INDUCES) 22405274 1 0 0 -GRIN2B NMDAR2B Channel, calcium; Channel, ligand-gated; Membrane protein, integral; Membrane protein, multi-pass Q13224 2904 12p13.1 human S1415-p 1874095504 QPTVAGAsKARPDFR NMDAR2_C activity, induced 34252035 1 1 0 -Tp63 p63 DNA-binding; Transcription factor O88898 22061 16 B1|16 17.37 cM mouse S41-p 27937106 SYYRSAMsQSTQTSE transcription, induced 24366874 1 0 0 induces REDD1 expression -STK16 MPSK1 EC 2.7.10.2; EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, Other; Protein kinase, Ser/Thr (non-receptor); Protein kinase, tyrosine (non-receptor) O75716 8576 2q35 human Y198-p 2028407 AQRCTISyRAPELFS Pkinase intracellular localization; phosphorylation; enzymatic activity, induced cell cycle regulation 31574902 2 0 0 decrease 4EBP1 phosphorylation by Y198 mutation -HMGCR HMGCR EC 1.1.1.34; Endoplasmic reticulum; Membrane protein, integral; Membrane protein, multi-pass; Motility/polarity/chemotaxis; Oxidoreductase; Secondary Metabolites Metabolism - terpenoid backbone biosynthesis P04035 3156 5q13.3 human K248-ub 10844794 VLEEEENkPNPVTQR protein degradation; ubiquitination 20458442; 31323021 3 8 25 mutationsdid not reduce sterol-induced degradation of HMGCR, Ubiad1 (WT) or Ubiad1 (G184R) did not increase the amount of mutant HMGCR (K89R, K248R) -KMT2A MLL Cell cycle regulation; EC 2.1.1.43; METHYLTRANSFERASE; Methyltransferase; Methyltransferase, protein lysine; Oncoprotein; Transcription factor Q03164 4297 11q23.3 human S516-p 4709074 VHPPLPIsQSPENES protein stabilization; molecular association, regulation; intracellular localization cell cycle regulation SKP2(DISRUPTS) 20818375 1 2 0 accumulates on chromatin -SLC6A6 TAUT Membrane protein, integral; Membrane protein, multi-pass; Transporter; Transporter, SLC family Q00589 404000 dog S322-p 450688 YNKYKYNsYRDCMLL SNF activity, inhibited 10477138 1 0 0 Taurine transport mediated by the S322A mutant was increased 3-fold as compared with the wild-type molecule -CASP8AP2 CASP8AP2 Apoptosis; Nuclear receptor co-regulator Q9UKL3 9994 6q15 human K1813-sm 8474900 EVKKDELkSEPGSNC transcription, induced 19615980 1 0 0 K1813R mutant coexpressed with SENP1 -Itpr1 IP3R1 Channel, calcium; Channel, ligand-gated; Membrane protein, integral; Membrane protein, multi-pass P29994 25262 4q41 rat T945-p 3635217 GGGFLPMtPMAAAPE molecular association, regulation 22878752 1 3 11 T945 phosphorylation reduces IP3 binding affiinity and Ca2+ release is reduced. -TCF3 E2A Cell development/differentiation; DNA-binding; Oncoprotein; Transcription factor P15923 6929 19p13.3 human S39-p 15500103 NGKGRPAsLAGAQFG intracellular localization cell motility, induced; cell adhesion, inhibited 26212009 1 2 1 colon cancer metastasis, importing into the nucleus, promotes epithelial mesenchymal transition -Hcn2 HCN2 Channel, cation; Membrane protein, integral; Membrane protein, multi-pass O88703 15166 10|10 C1 mouse S641-p 18454000 DRIGKKNsILLHKVQ activity, inhibited 21347269 1 1 0 -Opn4 melanopsin GPCR, family 1; Membrane protein, integral; Membrane protein, multi-pass; Receptor, GPCR Q9QXZ9 30044 14|14 B mouse S392-p 1868515102 THRSTLSsQSSDLSW molecular association, regulation; protein conformation ARRB1(INDUCES) 32236094 1 1 0 -PAK2 PAK2 EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, STE; Protein kinase, Ser/Thr (non-receptor) Q13177 5062 3q29 human S20-p 448298 APPVRMSsTIFSTGG carcinogenesis, induced; cell growth, induced 26218748; 31969394 8 11 100 -DUSP10 DUSP10 EC 3.1.3.16; EC 3.1.3.48; Motility/polarity/chemotaxis; PHOSPHATASE; Protein phosphatase, dual-specificity Q9Y6W6 11221 1q41 human S224-p 38520204 SCREGKDsFKRIFSK Rhodanese cell growth, inhibited; apoptosis, induced 25568665 1 0 0 -Jak2 JAK2 EC 2.7.10.2; KINASE; Kinase, protein; Oncoprotein; Protein kinase, TK; Protein kinase, tyrosine (non-receptor) Q62120 16452 19 C1|19 23.73 cM mouse Y613-p 1811800 HKHLVLNyGVCVCGE PK_Tyr_Ser-Thr enzymatic activity, induced 18160720 1 0 0 Y613E mutant shows constitutive activation of Jak2, which depends on the presence of EpoR -Vcl Vinculin Cell adhesion; Cytoskeletal; Motility/polarity/chemotaxis Q64727 22330 14 A3|14 11.53 cM mouse S721-p 3181157 DEAIDTKsLLDASEE Vinculin molecular association, regulation; protein conformation; activity, inhibited apoptosis, induced CTNNB1(DISRUPTS); CTNNA1(DISRUPTS); CDH5(DISRUPTS) 36380599 1 50 0 -C16orf74 C16orf74 Q96GX8 404550 16q24.1 human T44-p 3209115 DIIITPPtPTGMMLP DUF4597 molecular association, regulation cell motility, induced PPP3CA(INDUCES) 28881575 1 14 15 PDAC cell invasion -RIOK2 RIOK2 EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, Ser/Thr (non-receptor); Protein kinase, atypical Q9BVS4 55781 5q15 human S548-p 21241902 KSSLEAAsFWGE___ cell cycle regulation 21880710 1 1 0 -Oprm1 MOR-1 GPCR, family 1; Membrane protein, integral; Membrane protein, multi-pass; Receptor, GPCR P33535 25601 1q11 rat S261-p 447781 LMILRLKsVRMLSGS 7tm_1 receptor desensitization, altered MOR-1(NOT_REPORTED) 9326307 2 0 2 -STK4 MST1 Autophagy; EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, STE; Protein kinase, Ser/Thr (non-receptor) Q13043 6789 20q13.12 human T387-p 450050 TMKRRDEtMQPAKPS protein stabilization; intracellular localization; enzymatic activity, inhibited; enzymatic activity, induced; phosphorylation apoptosis, altered; apoptosis, inhibited 17726016; 20513427; 34348155 6 2 7 -Pdzrn3 PDZRN3 EC 6.3.2.-; Ligase; UBIQUITIN LIGASE; Ubiquitin conjugating system; Ubiquitin ligase Q69ZS0 55983 6|6 D3 mouse T955-p 25304555 REERSGLtTDDDAMS protein degradation cell motility, inhibited 34135125 1 4 2 -Sox9 SOX9 DNA-binding; Transcription factor Q04887 20682 11 E2|11 77.27 cM mouse S64-p 451039 EPDLKKEsEEDKFPV Sox_N activity, induced transcription, altered 19113914 6 0 0 promotes expression of osteochondrogenic markers -MCL1 MCL1 Apoptosis; Channel, misc.; Inhibitor; Membrane protein, integral; Mitochondrial Q07820 4170 1q21.2 human S121-p 1172400 PAADAIMsPEEELDG protein degradation; protein stabilization; molecular association, regulation; ubiquitination cell cycle regulation; carcinogenesis, inhibited; apoptosis, induced FBXW7(INDUCES) 12223490; 21368833; 21368834; 26205817; 27738316 7 4 0 -GRK1 GRK1 EC 2.7.11.14; KINASE; Kinase, protein; Protein kinase, AGC; Protein kinase, Ser/Thr (non-receptor) Q15835 6011 13q34 human S491-p 2530401 IQDVGAFsTVKGVAF molecular association, regulation Rhodopsin(INDUCES) 34262173 3 1 0 -Cldn16 Claudin-16 Cell adhesion; Membrane protein, integral; Membrane protein, multi-pass Q91Y55 155268 11q22 rat T233-p 11555106 AKMYAVDtRV_____ intracellular localization 19914201 2 0 0 -Arhgef2 ARHGEF2 GEF; GEF, Rac/Rho; Motility/polarity/chemotaxis Q60875 16800 3|3 F1 mouse S143-p 10991696 GSRRGLSsLSLAKSV molecular association, regulation; intracellular localization cytoskeletal reorganization DYNLT1(DISRUPTS) 22405273 2 7 4 reduced microtubule localization in S143D mutnt -Syk Syk EC 2.7.10.2; KINASE; Kinase, protein; Protein kinase, TK; Protein kinase, tyrosine (non-receptor) P48025 20963 13 A5|13 27.41 cM mouse Y342-p 447659 LPMDTEVyESPYADP molecular association, regulation; phosphorylation; enzymatic activity, induced endocytosis, altered; cell motility, altered; cell adhesion, altered; signaling pathway regulation FGR(INDUCES) 11672534; 12077122; 15536084; 15576379; 27609517; 35753354 15 12 112 Mutant Y342F/346F Syc showed less efficient FcERI-induced degranulation, and delayed calcium influx. ; induces AKT/ERK phosphorylation and GPVI-mediated signaling; AKT phosphorylation -LRRK2 LRRK2 EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, Ser/Thr (non-receptor); Protein kinase, TKL Q5S007 120892 12q12 human Y2018-p 1873559812 IIAKIADyGIAQYCC Pkinase phosphorylation 34088839 1 0 0 LRRK2 fragment (aa1327-2527) carrying mutation Y2018F increases phosphorylation of Rab8a in vitro -Brsk2 BRSK2 EC 2.7.11.1; EC 2.7.11.26; KINASE; Kinase, protein; Protein kinase, CAMK; Protein kinase, Ser/Thr (non-receptor) Q69Z98 75770 7|7 F5 mouse T502-p 17554455 RRKLQVPtPEEMSNL protein stabilization; enzymatic activity, inhibited; phosphorylation 23790753 1 1 0 inhibits axon branching (activated in BRSK2 18A mutant) -SKA3 SKA3 Cell cycle regulation Q8IX90 221150 13q12.11 human S283-p 31863083 SDAEYTNsPLVPTFC molecular association, regulation; intracellular localization cell cycle regulation; chromatin organization, altered; cytoskeletal reorganization HEC1(INDUCES) 32491969 1 4 0 -HES1 HES1 Cell development/differentiation; Motility/polarity/chemotaxis; Transcription factor Q14469 3280 3q29 human S38-p 3882731 ASEHRKSsKPIMEKR HLH molecular association, regulation cytoskeletal reorganization; transcription, altered DNA(DISRUPTS) 9389649 1 0 1 in vivo neurite outgrowth -Zap70 ZAP70 EC 2.7.10.2; KINASE; Kinase, protein; Protein kinase, TK; Protein kinase, tyrosine (non-receptor) P43404 22637 1 B|1 15.41 cM mouse K552-ub 1877703500 PEVLDFIkQGKRMEC PK_Tyr_Ser-Thr protein degradation 31061531 1 1 0 -Sp1 SP1 C2H2-type zinc finger protein; DNA-binding; Transcription factor O89090 20683 15|15 F3 mouse S493-gl 4283200 LAPMQGVsLGQTSSS molecular association, regulation transcription, inhibited Oct1(DISRUPTS) DNA(DISRUPTS) 19070619 3 1 0 inhibits the Sp1?Oct1 cooperative activation of the U2 snRNA promoter -Cdkn1b p27Kip1 Cell cycle regulation; Inhibitor; Oncoprotein; Protein kinase, regulatory subunit P46414 12576 6 G1|6 65.77 cM mouse S10-p 447874 NVRVSNGsPSLERMD protein stabilization; intracellular localization cell cycle regulation; cell growth, induced; cell growth, altered CCNA1(DISRUPTS); CCNE1(DISRUPTS); CCND1(DISRUPTS) 15010468; 15528185; 16391232; 20810788; 20837141; 21317921 47 36 1 interaction is in vivo, not in vitro (due to localization); neurite outgrowth -TOP1 TOP1 EC 5.99.1.2; Isomerase; Nucleolus; Oncoprotein P11387 7150 20q12 human K153-sm 2793909 DYKPKKIkTEDTKKE molecular association, regulation; intracellular localization apoptosis, induced DNA(INDUCES) 12149243; 12439742 3 2 0 increase in CPT-induced apoptosis; enhances TOPO1-DNA cleavable complex formation induced by CPT -EHD3 EHD3 Q9NZN3 30845 2p23.1 human K511-sm 49176401 ANHLIKVkLEGHELP EF-hand_4 receptor recycling, induced; intracellular localization endocytosis, altered 26226295 1 0 0 tubulation of the endocytic recycling compartment (ERC) membranes and efficient recycling -MAP3K7 TAK1 EC 2.7.11.25; KINASE; Kinase, protein; Protein kinase, Ser/Thr (non-receptor); Protein kinase, TKL O43318 6885 6q15 human T444-p 7444663 RRSIQDLtVTGTEPG molecular association, regulation IKKG(INDUCES) 29511289 1 6 0 -Apbb1 Fe65 Adaptor/scaffold; Apoptosis; Transcription regulation Q9QXJ1 11785 7 E3|7 55.9 cM mouse Y547-p 451143 VQKFQVYyLGNVPVA PID transcription, induced 15031292 2 1 0 -APBB1 Fe65 Adaptor/scaffold; Apoptosis; Transcription regulation O00213 322 11p15.4 human K701-ac 1881304500 QSLWGSLkPKRLGAH transcription, induced 33938178 1 0 0 -DES desmin Cytoskeletal; Motility/polarity/chemotaxis P17661 1674 2q35 human T76-p 449615 LRASRLGtTRTPSSY Filament_head cytoskeletal reorganization 12686604 1 0 0 Mutated desmin sites showed failure of desmin filaments to segregate into daughter cells. -WDR62 WDR62 Adaptor/scaffold O43379 284403 19q13.12 human S52-p 3175154 RTRLSTAsEETVQNR cell cycle regulation 26713495 2 11 33 WDR62 regulation of the mitotic spindle -TXNIP TXNIP Apoptosis; Mitochondrial; Motility/polarity/chemotaxis; Tumor suppressor Q9H3M7 10628 1q21.1 human S308-p 277409200 GLSSRTSsMASRTSS protein degradation 23453806 2 0 0 -AKT1 Akt1 EC 2.7.11.1; KINASE; Kinase, protein; Oncoprotein; Protein kinase, AGC; Protein kinase, Ser/Thr (non-receptor) P31749 207 14q32.33 human K64-sm 1881330701 VAQCQLMkTERPRPN phosphorylation; enzymatic activity, induced neural plasticity; signaling pathway regulation 34288124 1 0 0 Sumoylation at K64 and K276 increases T308 phosphorylation upregulates kinase activity.activates ERK-Elk-1Arc/BDNF and mTOR-P70S6k-4E-BP1 signaling, hippocampal LTP regulation -Mapk1 ERK2 EC 2.7.11.24; KINASE; Kinase, protein; Protein kinase, CMGC; Protein kinase, Ser/Thr (non-receptor) P63086 116590 11q23 rat T188-p 3949250 FLTEYVAtRWYRAPE Pkinase enzymatic activity, induced 26658610 4 17 17 -FANCD2 FANCD2 DNA repair, damage Q9BXW9 2177 3p25.3 human S886-p 31867427 TSSSDTLsEEKNSEC FancD2 molecular association, regulation; ubiquitination; intracellular localization; activity, inhibited cell cycle regulation; DNA repair, inhibited; signaling pathway regulation DNA(DISRUPTS) 31167143 1 3 0 inhibits Fanconi anemia pathway leading to inhibition of DNA repair; 882-898 cluster -Pag1 PAG Adaptor/scaffold; Membrane protein, integral Q9JM80 64019 2q23 rat Y183-p 454746 NMVEDCLyETVKEIK PAG cell growth, altered 18498747 2 22 115 -TERT TERT DNA-binding; EC 2.7.7.49; Nucleolus; Transferase O14746 7015 5p15.33 human S824-p 11418801 AVRIRGKsYVQCQGI RVT_1 intracellular localization; enzymatic activity, induced 10224060; 22902867 2 0 0 -DDX17 DDX17 iso3 EC 3.6.4.13; Helicase; Nuclear receptor co-regulator; Nucleolus; RNA processing; RNA-binding; Spliceosome; Transcription, coactivator/corepressor Q92841-3 10521 22q13.1 human K30-ac 15211506 GGGLPPKkFGNPGER protein stabilization; molecular association, regulation cell cycle regulation; apoptosis, inhibited HDAC3(INDUCES); HDAC1(INDUCES) 20663877 1 1 13 -SAV1 SAV1 Adaptor/scaffold Q9H4B6 60485 14q22.1 human S27-p 7447103 KYVKKETsPLLRNLM protein conformation apoptosis, induced 21944251 1 8 0 self-dimerization; increase in protein level -FRS2 FRS2 Adaptor/scaffold Q8WU20 10818 12q15 human Y471-p 473102 PTRRTELyAVIDIER molecular association, regulation cell differentiation, induced SHP-2(INDUCES) 11278583 2 2 15 -Ncoa3 SRC-3 ACETYLTRANSFERASE; Acetyltransferase; EC 2.3.1.48; Motility/polarity/chemotaxis; Nuclear receptor co-regulator; Transcription, coactivator/corepressor O09000 17979 2|2 H3 mouse R839-me 2363406 PQPVQSVrPPYNRAV protein degradation transcription, inhibited CBP(INDUCES) 17043108 1 0 0 -Sox9 SOX9 DNA-binding; Transcription factor Q04887 20682 11 E2|11 77.27 cM mouse R74-me 10338208 DKFPVCIrEAVSQVL Sox_N molecular association, regulation cell cycle regulation; cell growth, induced; transcription, induced CTNNB1(DISRUPTS) 19725955 1 0 0 promotes cyclin D1 expression, regulates endochondral ossification, chondrocyte/cartilage development during embryogenesis -CACB CACNA1C Channel, calcium; Membrane protein, integral; Membrane protein, multi-pass P15381 100101555 rabbit S1700-p 4714250 PEIRRAIsGDLTAEE CAC1F_C activity, induced 20876873; 36215501 17 7 0 induces CaV1.2 activity; regulates basal activity of CACNA1C channels; required for stimulation of CACNA1C channels activity -RAF1 RAF1 EC 2.7.11.1; KINASE; Kinase, protein; Oncoprotein; Protein kinase, Ser/Thr (non-receptor); Protein kinase, TKL P04049 5894 3p25.2 human T269-p 447747 NVHMVSTtLPVDSRM enzymatic activity, induced 11134016; 7477354; 9094715 5 0 0 -Ulk1 ULK1 Autophagy; EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, Other; Protein kinase, Ser/Thr (non-receptor) O70405 22241 5|5 F mouse S991-p 1869357208 HAVQMVQsAALDEMF DUF3543 cell cycle regulation; autophagy, induced; cell growth, induced 32516310 1 0 0 -PDGFRA PDGFRA EC 2.7.10.1; KINASE; Kinase, protein; Membrane protein, integral; Oncoprotein; Protein kinase, TK; Protein kinase, tyrosine (receptor) P16234 5156 4q12 human Y742-p 448657 KQADTTQyVPMLERK PK_Tyr_Ser-Thr molecular association, regulation PIK3R1(INDUCES) 11818394 2 11 102 -Ikbkb IKKB EC 2.7.11.10; KINASE; Kinase, protein; Protein kinase, Other; Protein kinase, Ser/Thr (non-receptor) O88351 16150 8|8 A2 mouse S679-p 5735027 SPDSMNVsRLSHPGQ molecular association, regulation; phosphorylation PPP2R3C(INDUCES) 20925653 1 5 0 interaction with PPP2R3C (aka G4-1) downregulates IKK-beta activity; S181 phosphorylation increased in S679/682/689/692/697/701/705A mutant -PPP1R12A MYPT1 Motility/polarity/chemotaxis; PHOSPHATASE; Protein phosphatase, regulatory subunit O14974 4659 12q21.2-q21.31 human S910-p 1983104 SLLGRSGsYSYLEER cell adhesion, altered 20354225 3 43 60 -MCM3 MCM3 DNA replication; EC 3.6.4.12 P25205 4172 6p12.2 human K748-ub 22247293 ESRLKAFkVALLDVF cell cycle regulation 27621311 1 2 0 KEAP1-MCM3 associates with chromatin in a cell cycle-dependent manner -DNMT1 DNMT1 Amino Acid Metabolism - cysteine and methionine; Cell development/differentiation; EC 2.1.1.37; METHYLTRANSFERASE; Methyltransferase; Methyltransferase, DNA; Transcription regulation P26358 1786 19p13.2 human K957-sm 12726306 IKLSSPVkRPRKEPV BAH enzymatic activity, induced DNA(INDUCES) 19450230 1 0 0 -Pdpk1 PDK1 EC 2.7.11.1; KINASE; Kinase, protein; Nuclear receptor co-regulator; Protein kinase, AGC; Protein kinase, Ser/Thr (non-receptor) O55173 81745 10q12 rat S244-p 447693 SKQARANsFVGTAQY Pkinase enzymatic activity, induced 11570885 63 95 264 -INSR INSR EC 2.7.10.1; KINASE; Kinase, protein; Membrane protein, integral; Protein kinase, TK; Protein kinase, tyrosine (receptor) P06213 3643 19p13.2 human Y1189-p 447681 RDIYETDyYRKGGKG PK_Tyr_Ser-Thr molecular association, regulation; receptor internalization, altered; enzymatic activity, induced signaling pathway regulation; transcription, altered IRS2(INDUCES); APS(INDUCES); PTP1B(INDUCES) 10852715; 11850117; 14690593; 1658004; 22081023; 34208786; 8024702; 8999839; 9195949 52 36 707 prolactin transcription; insulin pathway regulation -AR AR DNA-binding; Nuclear receptor; Transcription factor P10275 367 Xq12 human K634-ac 458904 LGARKLKkLGNLKLQ activity, induced; protein stabilization; molecular association, regulation; phosphorylation carcinogenesis, inhibited; apoptosis, induced; transcription, induced; transcription, altered; signaling pathway regulation p300(INDUCES) 11971970; 11994312; 15123687; 16860317; 17483368; 18022799; 22131404 7 0 0 has differential effect on different promoters; limits transcriptional activity -WNK4 WNK4 EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, Other; Protein kinase, Ser/Thr (non-receptor) Q96J92 65266 17q21.2 human S1190-p 477191 SSRQRRLsKGSFPTS activity, induced; phosphorylation 23054253; 23673010 6 4 0 inhibits phosphorylation at S1201; BK channel activity induced; regulates NKCC2 activity -DLC1 DLC1 GAP; GAP, Rac/Rho; Tumor suppressor Q96QB1 10395 8p22 human S766-p 458383 VTRTRSLsACNKRVG molecular association, regulation; intracellular localization; protein conformation; activity, inhibited cell growth, induced RHOA(DISRUPTS); DLC1(INDUCES) 29114068 2 3 1 greatly attenuates its RhoGAP and tumor-suppressor functions; becomes monomer; alters its focal adhesion (FA) localization -SNCA SNCA Adaptor/scaffold P37840 6622 4q22.1 human K45-ub 1877722303 LYVGSKTkEGVVHGV Synuclein protein degradation; ubiquitination 31167929 1 1 0 ubiquitination and degradation of internalized SNCA fibrils -Ppp1r3a PPP1R3A Membrane protein, integral; Protein phosphatase, regulatory subunit D3ZM60 500036 4q21 rat S67-p 449321 TSASRRVsFADSLGF activity, inhibited 10973812 6 1 0 inhibits glycogen synthase activity -TBX21 TBX21 DNA-binding; Transcription factor Q9UL17 30009 17q21.32 human Y220-p 20583307 SMPGNRLyVHPDSPN T-box molecular association, regulation cell differentiation, altered; cell growth, induced; transcription, induced DNA(INDUCES) 21690296 1 0 0 -RPS3 RPS3 Apoptosis; EC 4.2.99.18; RNA-binding; Ribosomal; Translation P23396 6188 11q13.4 human S209-p 9765788 KPLPDHVsIVEPKDE intracellular localization 21399639 1 8 0 -ARHGEF9 ARHGEF9 GAP; GAP, Rac/Rho O43307 23229 Xq11.1 human K516-ub 1873595604 SRLTPFKk_______ protein degradation 29069083 1 0 0 regulates gephyrin clustering and dendritic arborization -Eif4g1 eIF4G RNA-binding; Translation; Translation initiation Q6NZJ6 208643 16|16 B1 mouse R689-m1 6009525 LSNRGPPrGGPGGEL protein stabilization translation, induced 28655788 1 6 61 -LAX1 LAX1 Adaptor/scaffold; Membrane protein, integral Q8IWV1 54900 1q32.1 human Y373-p 460158 SNEDSSDyENVLTAK LAX molecular association, regulation transcription, inhibited; signaling pathway regulation GRB2(INDUCES); GADS(INDUCES); PIK3R1(INDUCES) 12359715 1 5 69 -FOXM1 FOXM1 DNA-binding; Transcription factor Q08050 2305 12p13.33 human T627-p 3194576 TPESWRLtPPAKVGG protein stabilization transcription, induced 22094256 1 6 5 -Ctla4 CTLA-4 Immunoglobulin superfamily; Membrane protein, integral P09793 12477 1 C2|1 30.58 cM mouse Y201-p 450897 SPLTTGVyVKMPPTE molecular association, regulation; receptor internalization, altered; intracellular localization JAK2(INDUCES); SHP-2(INDUCES) 10842319; 24648182; 9973379 5 0 1 Phosphorylation of Y201 in Jurkat cells correlated with cell surface accumulation of CTLA-4.; increases surface level expression, Treg-cell function, increased IL-4 production, increased FoxP3 expression -CITED2 CITED2 Apoptosis; Cell cycle regulation; Motility/polarity/chemotaxis; Nuclear receptor co-regulator; Transcription, coactivator/corepressor Q99967 10370 6q24.1 human T166-p 27145810 KHSGGSStPGGSGGS CITED transcription, induced 23082118 1 0 0 -ARHGDIA RhoGDI alpha Apoptosis; Cell adhesion; Cell development/differentiation; G protein regulator, misc.; Motility/polarity/chemotaxis P52565 396 17q25.3 human S101-p 452195 LESFKKQsFVLKEGV Rho_GDI molecular association, regulation; enzymatic activity, inhibited; phosphorylation RAC1(DISRUPTS); RhoGDI alpha(INDUCES); CDC42 iso1(DISRUPTS) 20028975; 24820414; 32003021 6 11 1 affects phosphorylation of RhoGDI alpha S174; regulate the local accumulation of active Rac1 -GSN Gelsolin iso3 Actin-binding; Motility/polarity/chemotaxis; Nuclear receptor co-regulator; Secreted; Secreted, signal peptide P06396-3 2934 9q33.2 human Y438-p 23109545 GDSYIILyNYRHGGR Gelsolin protein stabilization; activity, inhibited cell motility, induced; cytoskeletal reorganization 23791551 1 0 1 -SNAI1 Snail1 C2H2-type zinc finger protein; Transcription factor O95863 6615 20q13.13 human S100-p 6097704 DEDSGKGsQPPSPPS protein degradation; ubiquitination; intracellular localization cell motility, altered; transcription, altered FBW1B(INDUCES) 15448698; 19004823 4 0 0 Localization mediated by S107, S111, S115 and S119. -LMNB2 Lamin B2 Cytoskeletal; Motility/polarity/chemotaxis P14732 chicken S410-p 20657002 SSTSLVRsSRGKRRR intracellular localization 8449977 1 0 0 nuclear uptake inhibited in vitro -CSNK2A1 CK2A1 EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, Other; Protein kinase, Ser/Thr (non-receptor) P68400 1457 20p13 human K102-ac 11322071 ITLADIVkDPVSRTP Pkinase enzymatic activity, induced 20608637 1 3 0 -Cacnb1 CACNB1 Channel, calcium P54283 50688 10q31 rat S161-p 459045 CEVGFIPsPVKLDSL activity, induced 16406008 1 0 0 -KAT2A GCN5 ACETYLTRANSFERASE; Acetyltransferase; EC 2.3.1.48 Q92830 2648 17q21.2 human S307-p 27421701 HVPQSCDsLPRYETT PCAF_N acetylation; enzymatic activity, induced transcription, altered 23142079 1 1 0 direct opposition to Sirt1; increases PGC-1a acetylation; Regulates the gluconeogenic transcriptional response of fasted mice -KCNMA1 KCNMA1 Channel, potassium; Endoplasmic reticulum; Membrane protein, integral; Membrane protein, multi-pass Q12791 3778 10q22.3 human S1200-p 9805700 SHSSQSSsKKSSSVH activity, induced 19592459 1 0 0 -Pou1f1 GHF-1 DNA-binding; Transcription factor P10037 25517 11p12 rat T220-p 451518 RKRKRRTtISIAAKD Homeodomain molecular association, regulation; activity, inhibited transcription, inhibited Ets-1(INDUCES) DNA(DISRUPTS) 12242337; 19887646; 8524234 3 0 0 Phosphorylation of T220 inhibits DNA-binding activity of GHF-1.; stimulates binding to dimeric, but not to monomeric GHF-1 sites in the rPRL promoter -MAP2K1 MEK1 EC 2.7.12.2; KINASE; Kinase, protein; Protein kinase, STE; Protein kinase, dual-specificity (non-receptor) Q02750 5604 15q22.31 human S298-p 448284 RTPGRPLsSYGMDSR Pkinase molecular association, regulation; protein conformation carcinogenesis, induced; cell motility, induced; apoptosis, inhibited; cell adhesion, induced; transcription, induced; signaling pathway regulation; cell growth, altered ERK1(INDUCES); Akt1(INDUCES); RAF1(INDUCES) 14993270; 17667937; 28225038; 33789117; 36319849; 9351825 25 4 1 Interaction with AKT induces FOXO1 phosphorylation; metastasis in nude mice ; induces the MAPK pathway; induces ERK pathway -Abca1 ABCA1 Membrane protein, integral; Membrane protein, multi-pass; Transporter; Transporter, ABC family; Vesicle P41233 11303 4 B2|4 28.57 cM mouse T1286-p 450308 QSCLHPFtEDDAVDP protein degradation; protein processing 12869555 1 0 0 Mutants showed increase of cell surface protein levels. ; T1286A and T1305A mutants are not degraded by calpain or stabilized by apoA-1. -NCAM1 NCAM1 Cell adhesion; Membrane protein, GPI anchor; Membrane protein, integral; Motility/polarity/chemotaxis P13591 4684 11q23.2 human Y744-p 454070 VVVDITCyFLNKCGL cell growth, altered 15313190 2 0 0 phosphorylation of this residue plays a role in the FGFR1- mediated cell signaling -POU2F1 Oct1 DNA-binding; Transcription factor P14859 5451 1q24.2 human S335-p 10424763 RFEALNLsFKNMCKL Pou transcription, inhibited 25937278 1 13 1 transcription of miR-451 in response to glucose availability -LGMN LGMN EC 3.4.22.34; Protease Q99538 5641 14q32.12 human S226-p 183811000 CYYDEKRsTYLGDWY Peptidase_C13 enzymatic activity, induced 28826672 1 0 0 AD Pathologies in Young 3xTg mice, stimulating cognitive dysfunction -NCOA3 SRC-3 ACETYLTRANSFERASE; Acetyltransferase; EC 2.3.1.48; Motility/polarity/chemotaxis; Nuclear receptor co-regulator; Transcription, coactivator/corepressor Q9Y6Q9 8202 20q13.12 human S601-p 7596700 SDKESKEsSVEGAEN protein stabilization transcription, induced 19339517 1 0 0 -Grm7 mGluR7 GPCR, family 3; Membrane protein, integral; Membrane protein, multi-pass; Receptor, GPCR P35400 81672 4q41 rat K889-sm 25042302 DRPNGEAkTELCENV sumoylation endocytosis, altered 26631532 2 0 0 -Lgmn LGMN EC 3.4.22.34; Protease O89017 19141 12|12 E mouse T324-p 23121345 LKRKLLRtNDVKESQ activity, inhibited neural plasticity; signaling pathway regulation 31004063; 34343610 2 0 1 -VIL1 Villin Actin-binding; Motility/polarity/chemotaxis P09327 7429 2q35 human Y286-p 469579 LLSHEDCyILDQGGL Gelsolin cell motility, altered; cytoskeletal reorganization 16921170 1 0 0 -CRYAB CRYAB Chaperone; Heat shock protein P02511 1410 11q23.1 human S59-p 448783 PSFLRAPsWFDTGLS activity, induced; molecular association, regulation; intracellular localization; protein conformation exocytosis, inhibited; apoptosis, inhibited CASP7(INDUCES); CRYAB(DISRUPTS); CASP3(INDUCES); GEMIN3(INDUCES); CASP2(DISRUPTS) 11096101; 15511225; 16129694; 16928191; 18061612; 23049853; 24023879; 26620801; 27641668; 36232565 46 22 0 -BIRC5 Survivin Apoptosis O15392 332 17q25.3 human T34-p 447705 FLEGCACtPERMAEA BIR activity, induced; protein stabilization; molecular association, regulation; intracellular localization carcinogenesis, induced; cell motility, induced; transcription, induced; signaling pathway regulation; apoptosis, inhibited; cytoskeletal reorganization; transcription, inhibited; cell growth, altered CASP9(INDUCES) 11069302; 11149963; 11861764; 12517802; 12529428; 15735703; 15894279; 16170024; 18949405; 24478433; 25468890; 32373497; 33211707; 33710603; 34034636 19 6 7 -Flt3 FLT3 EC 2.7.10.1; KINASE; Kinase, protein; Membrane protein, integral; Oncoprotein; Protein kinase, TK; Protein kinase, tyrosine (receptor) Q00342 14255 5 86.88 cM|5 G3 mouse Y592-p 448190 PLDNEYFyVDFRDYE enzymatic activity, induced 16091740 14 0 0 -Kcnq3 Kv7.3 iso2 Channel, potassium; Membrane protein, integral; Membrane protein, multi-pass O88944-2 29682 7q34 rat Y67-p 453408 VKRNNAKyRRIQTLI activity, inhibited 15304482 1 0 0 inhibition of K(+) current via reducing open probability. -AURKB AurB EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, Other; Protein kinase, Ser/Thr (non-receptor) Q96GD4 9212 17p13.1 human K56-ub 12365733 PTAAPGQkVMENSSG ubiquitination; intracellular localization 26766443 1 8 4 localization in prometaphase cells -Nos1 nNOS Amino Acid Metabolism - arginine and proline; EC 1.14.13.39; Oxidoreductase Q9Z0J4 18125 5 F|5 57.29 cM mouse S1412-p 449830 TNRLRSEsIAFIEES activity, induced; enzymatic activity, induced signaling pathway regulation 24498331; 33434144; 36084555 14 0 0 induces p38MAPK pathway and inhibits insulin pathway -KIF3A KIF3A Microtubule-binding; Motor Q9Y496 11127 5q31.1 human S687-p 454304 KTGRRKRsAKPETVI molecular association, regulation; intracellular localization exocytosis, inhibited TUBA1A(INDUCES) 24338362; 25878107 3 28 2 Cargo transport, Only the phosphorylated KIF3A motor will move along the microtubules.; decrease intracellular trafficking and cell surface expression of CD1d -FMR1 FMR1 Nucleolus; RNA-binding; Translation Q06787 2332 Xq27.3 human R546-me 4046001 RGQGGRGrGGGFKGN RNA splicing, altered 16922515 5 0 0 S500 phosphorylation has no affect on methylation; alternatively spliced variant of FMR1 exon 15, reduced methylation by more than 85% -Esr2 ER-beta DNA-binding; Nuclear receptor O08537 13983 12 C3|12 33.52 cM mouse S105-p 447914 LYAEPQKsPWCEARS ERbeta_N molecular association, regulation transcription, altered SRC-1(INDUCES) 10230404; 9058381 5 1 0 -PICK1 PICK1 Adaptor/scaffold; Cell development/differentiation; Ligand, receptor tyrosine kinase Q9NRD5 9463 22q13.1 human S342-p 25749628 QRLVSTMsKYYNDCY Arfaptin molecular association, regulation GluR2(INDUCES) 26472923 1 0 1 S415 was essential for binding to GluA2 -FEN1 FEN1 DNA repair, damage; DNA-binding; Deoxyribonuclease; EC 3.1.-.-; Nuclear receptor co-regulator; Nucleolus; Ribonuclease P39748 2237 11q12.2 human K377-m1 1873595100 TGAAGKFkRGK____ DNA repair, induced 29029401 1 0 0 -FURIN FURIN Cell surface; EC 3.4.21.75; Membrane protein, integral; Protease; Vesicle P09958 5045 15q26.1 human S773-p 469742 AWQEECPsDSEEDEG intracellular localization 8846780 2 10 0 retrieval to the trans-Golgi network -CHEK2 Chk2 EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, CAMK; Protein kinase, Ser/Thr (non-receptor); Tumor suppressor O96017 11200 22q12.1 human T389-p 981400 RTLCGTPtYLAPEVL Pkinase intracellular localization; phosphorylation 20713355 2 2 0 prerequisite for T387 phosphorylation; chromatin targeting of S372, S379, T389, singly and T383/389, T378/S379 -BAD BAD Apoptosis Q92934 572 11q13.1 human S99-p 447862 PFRGRSRsAPPNLWA Bcl-2_BAD activity, induced; molecular association, regulation; phosphorylation carcinogenesis, induced; apoptosis, altered; apoptosis, inhibited; transcription, inhibited; cell growth, altered 14-3-3 beta(INDUCES); 14-3-3 zeta(INDUCES); Bcl-2(DISRUPTS); Bcl-xL(DISRUPTS); 14-3-3 beta(DISRUPTS) 10611223; 10926925; 11085518; 12897059; 12970779; 15121878; 17670745; 18794113; 19667065; 20566643; 21419810; 21444773; 21849418; 22096607; 34418433; 35725817; 37363966 124 55 216 -KHDRBS1 KHDRBS1 RNA-binding Q07666 10657 1p35.2 human R315-m1 476772 PPRGALVrGTPVRGA intracellular localization 12529443 1 4 14 -Ntrk2 TrkB EC 2.7.10.1; KINASE; Kinase, protein; Membrane protein, integral; Protein kinase, TK; Protein kinase, tyrosine (receptor) P15209 18212 13 B1|13 31.2 cM mouse Y816-sn 1881005700 LAKASPVyLDILG__ protein degradation; molecular association, regulation; ubiquitination; intracellular localization; protein conformation; phosphorylation endocytosis, induced; signaling pathway regulation AP2M1(INDUCES); PLCG1(DISRUPTS) 36682419 1 0 0 decreases phosphorylation of itself, impairs BDNF signaling -NPHP1 NPHP1 Cell adhesion O15259 4867 2q13 human S123-p 26395107 EEEEESEsEDSEDSG molecular association, regulation; intracellular localization PACS-1(INDUCES) 16308564 1 0 0 -BRAF BRAF EC 2.7.11.1; KINASE; Kinase, protein; Oncoprotein; Protein kinase, Ser/Thr (non-receptor); Protein kinase, TKL P15056 673 7q34 human S151-p 478631 VARSNPKsPQKPIVR molecular association, regulation signaling pathway regulation; cell growth, altered NRas(DISRUPTS); RAF1(DISRUPTS) 19933846; 21478863 3 30 34 MAPK pathway -DDX5 DDX5 EC 3.6.4.13; Helicase; Nuclear receptor co-regulator; Nucleolus; RNA splicing; RNA-binding; Spliceosome P17844 1655 17q23.3 human R486-m2 27280653 GSGRSRGrGGMKDDR molecular association, regulation XRN2(INDUCES) 31267554 1 2 1 represses R-loops -Mgmt MGMT Apoptosis; DNA repair, damage; EC 2.1.1.63; METHYLTRANSFERASE; Methyltransferase; Nuclear receptor co-regulator P24528 25332 1q41 rat S204-p 31918701 KPSFESSsPKPSG__ protein stabilization 11104689 1 0 0 resistant to proteases in vitro which are increased during DEN-induced hepatocarcinogenesis -Bcr Bcr EC 2.7.11.1; GAP; GAP, Rac/Rho; GEF, Rac/Rho; KINASE; Kinase, protein; Oncoprotein; Protein kinase, Ser/Thr (non-receptor); Protein kinase, atypical Q6PAJ1 110279 10 C1|10 38.49 cM mouse S356-p 447791 SGQSSRVsPSPTTYR enzymatic activity, inhibited cell growth, altered 17934518 3 13 60 -PSEN1 PSEN1 Cell surface; EC 3.4.23.-; Membrane protein, integral; Membrane protein, multi-pass; Mitochondrial; Protease P49768 5663 14q24.2 human T354-p 451669 HLGPHRStPESRAAV Presenilin protein stabilization; enzymatic activity, induced 12056836; 20456003 2 1 23 Phosphorylation of site stabilizes the C-terminal fragment of PSEN1.; increases gamma-secretase activity -ARHGEF7 ARHGEF7 GEF; GEF, Rac/Rho; Motility/polarity/chemotaxis Q14155 8874 13q34 human T704-p 455216 EFASRKStAALEEDA RhoGEF67_u2 activity, induced; molecular association, regulation cytoskeletal reorganization RAP1GDS1(DISRUPTS) 16954223 7 6 1 activates ARHGEF7's exchange activity on Rac1 -Gria3 GluR3 Channel, ligand-gated; Membrane protein, integral; Membrane protein, multi-pass Q9Z2W9 53623 X A4|X 23.19 cM mouse Y881-p 461043 YREGYNVyGTESVKI neural plasticity 32071234 2 1 95 -PRKDC DNAPK DNA repair, damage; EC 2.7.11.1; KINASE; Kinase, protein; Nucleolus; Protein kinase, Ser/Thr (non-receptor); Protein kinase, atypical P78527 5591 8q11.21 human S2674-p 3193634 LVDHTSPsSDSLLFA DNAPKcs_CC5 DNA repair, inhibited 24687855 1 2 0 cell survival inhibited -TBXA2R TXA2-R GPCR, family 1; Membrane protein, integral; Membrane protein, multi-pass; Receptor, GPCR P21731 6915 19p13.3 human T337-p 451395 LSLQPQLtQRSGLQ_ receptor desensitization, induced; receptor desensitization, altered signaling pathway regulation 15100160; 17466390 2 3 0 -INVS INVS Q9Y283 27130 9q31.1 human T795-p 1384540900 CAPQKRRtQELRGGR molecular association, regulation SMO(INDUCES) 30598432 1 0 0 -Hif3a HIF3A iso2 Transcription factor; Tumor suppressor Q0VBL6-2 53417 7|7 A2 mouse T12-p 57786401 LQRVRSNtELRKEKS molecular association, regulation; ubiquitination PARK2(INDUCES) 27551449 2 1 0 -TNNI3 TNNI3 Actin-binding; Motility/polarity/chemotaxis; Motor P19429 7137 19q13.42 human S42-p 450690 AKKKSKIsASRKLQL molecular association, regulation; activity, inhibited TNNC1(DISRUPTS) 15134451; 24116014 24 2 0 reduced maximal force generation -ZNF746 PARIS C2H2-type zinc finger protein; Transcription regulation Q6NUN9 155061 7q36.1 human S613-p 25759828 APPDPFKsPASKGPL protein degradation; ubiquitination 28122242 1 2 1 protective effect of DA neuron toxicity -YTHDF2 YTHDF2 RNA processing; RNA-binding Q9Y5A9 51441 1p35.3 human S39-p 483929 DDFEPYLsPQARPNN protein stabilization carcinogenesis, induced; cell growth, induced; apoptosis, inhibited; RNA stability, inhibited 33420027 1 24 12 -KCNMA1 KCNMA1 Channel, potassium; Endoplasmic reticulum; Membrane protein, integral; Membrane protein, multi-pass Q8AYS8 374065 chicken S883-p 4715384 DRSSPDNsPVHGLLR intracellular localization; activity, inhibited 22094329 1 5 0 -CSRP2 CSRP2 Cell development/differentiation Q16527 1466 12q21.2 human Y57-p 470028 AIHDEEIyCKSCYGK LIM intracellular localization transcription, altered 12771930 1 2 1 Nuclear translocation. -SMAD1 SMAD1 DNA-binding; Transcription factor Q15797 4086 4q31.21 human S214-p 451176 PTSSDPGsPFQMPAD molecular association, regulation; intracellular localization YAP1(INDUCES) 19914168; 9335504 3 0 0 Erk-mediated phosphorylation inhibits the nuclear accumulation of Smad1. -CRMP1 CRMP-1 Cell development/differentiation; Cytoskeletal; Hydrolase Q14194 1400 4p16.2 human S522-p 1295503 PAPSAKSsPSKHQPP cytoskeletal reorganization 18003833 4 12 7 Phosphorylation induces increased density of synaptic clusters and neurite projection. -OCLN occludin Cell adhesion; Membrane protein, integral; Membrane protein, multi-pass; Motility/polarity/chemotaxis Q91049 chicken Y379-p 5393504 PELDESQyETDYTTA molecular association, regulation; intracellular localization ZO1(INDUCES) 19017651 1 3 1 -PTPN1 PTP1B EC 3.1.3.48; Motility/polarity/chemotaxis; PHOSPHATASE; Phosphatase; Protein phosphatase, tyrosine (non-receptor) P18031 5770 20q13.13 human S50-p 447811 RNRYRDVsPFDHSRI Y_phosphatase molecular association, regulation; enzymatic activity, inhibited; enzymatic activity, induced signaling pathway regulation INSR(DISRUPTS) 10480872; 11579209; 20615878; 23481236 5 18 17 insulin signaling- glucose metabolism -Mpl MPL Membrane protein, integral; Receptor, cytokine Q08351 17480 4 D2.1|4 54.61 cM mouse S550-p 3091401 SKATVTDsCEEVEPS activity, induced; phosphorylation cell growth, altered 10918061 1 0 0 tyrosine phosphorylation of JAK2 -7a Accessory protein 7a P59635 1489674 SARSCoV1 K120-ub 1883544402 LCFTIKRkTE_____ molecular association, regulation; intracellular localization TAK1(INDUCES); IKKG(INDUCES) 35856559 1 0 0 Accessory protein 7a and | nsp6-pp1a-pp1ab ubiquitiylation are required for the recruitment of NEMO and TAK1 to ORF7a and required for NF-kB activation. -TP53 p53 Activator; DNA-binding; Motility/polarity/chemotaxis; Nuclear receptor co-regulator; Transcription factor; Tumor suppressor P04637 7157 17p13.1 human K132-ub 486294 TYSPALNkMFCQLAK P53 protein degradation; intracellular localization 17371868; 31346036; 31492752 3 2 0 -ARHGAP5 ARHGAP5 GAP; GAP, Rac/Rho; Motility/polarity/chemotaxis Q13017 394 14q12 human Y1109-p 455068 KGYSDEIyVVPDDSQ RhoGAP_pG1_pG2 activity, induced cell motility, altered; cell growth, altered 18829532 2 13 170 inhibits Rho activity, activates Ras activity -GTF2I GTF2I iso2 DNA-binding; Transcription, coactivator/corepressor P78347-2 2969 7q11.23 human Y357-p 448251 QSHVEDLyVEGLPEG GTF2I transcription, altered 11373296 1 1 2 -AKAP8 AKAP8 Adaptor/scaffold; Cell cycle regulation; Mitochondrial; RNA-binding O43823 10270 19p13.12 human Y170-p 15417596 NGSFGGQySECRDPA molecular association, regulation 25770215 1 1 1 Phenylalanine mutants inhibited dissociation from nuclear structures; structural chromatin changes -Kcnj1 ROMK Channel, potassium; Membrane protein, integral; Membrane protein, multi-pass P35560 24521 8q21 rat S219-p 2461201 RVANLRKsLLIGSHI IRK_C activity, induced; protein conformation 18311184 5 0 0 -TP53 p53 Activator; DNA-binding; Motility/polarity/chemotaxis; Nuclear receptor co-regulator; Transcription factor; Tumor suppressor P04637 7157 17p13.1 human K373-ac 458980 SSHLKSKkGQSTSRH protein degradation; molecular association, regulation; protein stabilization; phosphorylation; activity, induced; ubiquitination; intracellular localization; protein conformation cell cycle regulation; carcinogenesis, inhibited; cell growth, inhibited; apoptosis, induced; cell motility, inhibited; transcription, induced; transcription, altered; neural plasticity; autophagy, induced; cell growth, induced; apoptosis, inhibited; transcription, inhibited TAF1(INDUCES); p53(INDUCES); SIRT1(INDUCES); HDAC1(INDUCES); BANP(INDUCES); GTF2H1(INDUCES); p53(DISRUPTS); BCL2L2(INDUCES); FOXM1(INDUCES); p21Cip1(DISRUPTS); p300(INDUCES); SMARCA4(INDUCES); SIN3A(INDUCES); POLA2(INDUCES); FOXA1(INDUCES) DNA(INDUCES) 11094089; 11099047; 11250899; 11971195; 12716906; 14522900; 14759370; 14982997; 15141169; 15520174; 15746940; 16107876; 16291740; 16537920; 16540664; 16717128; 17121856; 17272277; 17403783; 17668048; 17977830; 17996705; 18056437; 18485870; 18523266; 18697203; 19085961; 19265193; 19339993; 19377469; 20075864; 20094059; 21297583; 22249259; 22285752; 22981429; 23148227; 23149944; 23384296; 23576563; 24330748; 25426556; 25521755; 26411366; 27208501; 27423454; 31196136; 31680191; 33097607; 34880421; 36257192; 9288740 95 4 0 After PEPD binding is dissrupted from P53 mutants, K373 acetylation is essential for activation and p53 mutants to refold, reactivates the transcription-dependent tumor suppressor activities of p53 mutants,inhibition of in vivo tumor growth; IKK-alpha and CHK1-dependent p53 phosphorylation and acetylation; promoting the C-terminal acetylation of p53 and may facilitate p53-dependent gene expression ; 20, 164, 305, 320, 370/372/373, 381/382/386 K-R mutants diminsished transactivation, and selective regulation of target genes expression through distinct mechanisms; autophagic degradation of IKKa during the arsenite response -Tnni3 TNNI3 Actin-binding; Motility/polarity/chemotaxis; Motor P23693 29248 1q12 rat T144-p 451483 RGKFKRPtLRRVRIS Troponin activity, inhibited cytoskeletal reorganization 16236710; 18550549; 30844361 29 2 1 increased myofilament Ca2+ sensitivity; regulates cardiac contractile function; acute acceleration of relaxation -SHC4 SHC4 Adaptor/scaffold Q6S5L8 399694 15q21.1 human T159-p 1868546600 GHRATALtPDSCPLP phosphorylation apoptosis, induced; transcription, induced; signaling pathway regulation 31121283 1 1 0 expression and phosphorylation of p21 -NEK6 NEK6 EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, Other; Protein kinase, Ser/Thr (non-receptor) Q9HC98 10783 9q33.3 human T210-p 9258030 AAHSLVGtPYYMSPE Pkinase enzymatic activity, induced cell growth, induced 20595392 1 2 17 -MCM3 MCM3 DNA replication; EC 3.6.4.12 P25205 4172 6p12.2 human K435-ub 12301894 QGRVTIAkAGIHARL MCM cell cycle regulation 27621311 1 6 15 KEAP1-MCM3 associates with chromatin in a cell cycle-dependent manner -Add1 ADD1 Cytoskeletal; Motility/polarity/chemotaxis Q9QYC0 11518 5 B2|5 17.9 cM mouse S465-p 452288 EEGQNGSsPKSKTKW intracellular localization 28982183 0 51 7 abnormal localization on the meiotic spindle -DAP3 DAP3 Apoptosis; Mitochondrial; Nuclear receptor co-regulator P51398 7818 1q22 human S251-p 2226201 LKELKRQsSLGMFHL DAP3 apoptosis, induced 18227431 1 1 0 -CTH CTH Amino Acid Metabolism - cysteine and methionine; Amino Acid Metabolism - glycine, serine and threonine; Cell cycle regulation; EC 4.4.1.1; Energy Metabolism - nitrogen; Lyase; Other Amino Acids Metabolism - selenoamino acid P32929 1491 1p31.1 human S377-p 484505 SDTLIRLsVGLEDEE Cys_Met_Meta_PP enzymatic activity, inhibited Akt1(INDUCES) 25900831; 26539823; 29970364; 31759247 5 4 0 -APOBEC3G APOBEC3G EC 3.5.4.-; Hydrolase; RNA processing; RNA-binding Q9HC16 60489 22q13.1 human K301-ub 11956701 EMAKFISkNKHVSLC NAD2 protein degradation 19887642 1 0 0 -Mdm4 MDM4 EC 6.3.2.-; Ligase; UBIQUITIN LIGASE; Ubiquitin conjugating system; Ubiquitin ligase O35618 17248 1 E4|1 57.75 cM mouse S288-p 456471 DDLEDSRsLSDDTDV molecular association, regulation p53(INDUCES) 29581299 5 0 0 CK1a cooperates with MDMX to inhibit p53 DNA binding -HDAC3 HDAC3 Apoptosis; Cell cycle regulation; DEACETYLASE; Deacetylase; EC 3.5.1.98; Nuclear receptor co-regulator; Transcription, coactivator/corepressor O15379 8841 5q31.3 human S374-p 1874020216 KMLNHAPsVQIHDVP molecular association, regulation; acetylation; enzymatic activity, inhibited transcription, inhibited DAD1(DISRUPTS) 34244427 1 1 0 inhibits deacetylation of p65 -TPX2 TPX2 Cell cycle regulation; Microtubule-binding Q9ULW0 22974 20q11.21 human S738-p 453052 QPLTVPVsPKFSTRF cell cycle regulation 29052541 2 78 7 mitotic delay -Pparg PPAR-gamma iso2 DNA-binding; Nuclear receptor; Transcription factor P37238-2 19016 6 E3|6 53.41 cM mouse K33-sm 7780002 HSHSFDIkPFTTVDF PPARgamma_N activity, inhibited 23826177 2 0 0 -Dcx Doublecortin Cytoskeletal; Motility/polarity/chemotaxis O88809 13193 X|X F2 mouse S297-p 451111 PQKTSAKsPGPMRRS activity, inhibited cell growth, inhibited; cytoskeletal reorganization CDK5(DISRUPTS) 14741103; 17482550; 26526391 8 1 4 S297A constitutively active mutant promotes neuronal survival and axon regeneration. -BAG3 BAG3 Apoptosis; Chaperone O95817 9531 10q26.11 human S187-p 12217052 SSSSSSAsLPSSGRS cell motility, induced 23108398 1 2 0 involved in epithelial-mesenchymal transition (EMT); promotes migration and invasion of FRO cells -RAB4A Rab4 G protein; G protein, monomeric; G protein, monomeric, Rab P20338 5867 1q42.13 human S204-p 451289 AALRQLRsPRRAQAP molecular association, regulation; intracellular localization autophagy, induced LC3A(INDUCES) 1425574; 24404161 2 0 0 phosphorylation-resistant Rab4 S204Q mutation promotes autophagy ; S199 phosphorylation was required for the accumulation of rab4 in the cytosol of mitotic cells. -OCLN occludin Cell adhesion; Membrane protein, integral; Membrane protein, multi-pass; Motility/polarity/chemotaxis Q16625 100506658 5q13.2 human T400-p 471470 TEQDHYEtDYTTGGE molecular association, regulation occludin(DISRUPTS); ZO2(DISRUPTS) 23758859 1 1 5 . Phosphorylation affects occludin solubility and regulates assembly/disassembly of TJ proteins -GLE1 GLE1 Karyopherin; Nuclear export Q53GS7 2733 9q34.11 human T102-p 472369 FSPASPAtPNGTKGK molecular association, regulation GLE1(INDUCES) 30429220 1 13 12 self-association stress granules' assembly and disassembly, DDX3-ATPase activity inhibited -MST1R Ron EC 2.7.10.1; KINASE; Kinase, protein; Membrane protein, integral; Protein kinase, TK; Protein kinase, tyrosine (receptor) Q04912 4486 3p21.31 human S1394-p 450270 VRRPRPLsEPPRPT_ molecular association, regulation 14-3-3 beta(INDUCES) 12919677; 14505491 2 2 22 -Cdc20 CDC20 Cell cycle regulation; Ubiquitin conjugating system Q62623 64515 5q36 rat S51-p 20653800 RAANRSHsAGRTPGR intracellular localization; activity, inhibited cell growth, inhibited 21725312 3 2 3 phosphorylation decreased dendritic length -Itpr1 IP3R1 Channel, calcium; Channel, ligand-gated; Membrane protein, integral; Membrane protein, multi-pass P11881 16438 6 E1|6 49.74 cM mouse S421-p 450268 VMLKIGTsPLKEDKE MIR activity, induced cell growth, induced 26259730; 36001172 4 0 1 -ITPR1 IP3R1 Channel, calcium; Channel, ligand-gated; Membrane protein, integral; Membrane protein, multi-pass Q14643 3708 3p26.1 human Y353-p 450970 NAQEKMVySLVSVPE MIR activity, induced; receptor desensitization, altered transcription, altered Other(NOT_REPORTED) 14761954; 18056410 4 0 0 -TP63 p63 iso2 DNA-binding; Transcription factor Q9H3D4-2 8626 3q28 human S301-p 451602 TSIKKRRsPDDELLY P53_tetramer protein degradation 30301786 2 4 0 -Kcnj8 KCNJ8 Channel, potassium; Membrane protein, integral; Membrane protein, multi-pass Q63664 25472 4q44 rat S354-p 1458600 RVAAPRCsARELDEK IRK_C activity, inhibited 18048350 1 0 0 -Slc1a2 GLT1 Membrane protein, integral; Membrane protein, multi-pass; Transporter; Transporter, SLC family P31596 29482 3q32 rat K570-ub 3884559 SVEEEPWkREK____ receptor internalization, induced; protein degradation 18805448 1 1 8 -ATM ATM DNA repair, damage; EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, Ser/Thr (non-receptor); Protein kinase, atypical; Tumor suppressor Q13315 472 11q22.3 human S85-p 481858 AKPNVSAsTQASRQK TAN molecular association, regulation; enzymatic activity, inhibited; protein conformation cell cycle regulation; apoptosis, inhibited MRE11A(DISRUPTS); NBS1(DISRUPTS) 27939942 1 4 0 -REST REST C2H2-type zinc finger protein; Cell development/differentiation; DNA-binding; Transcription factor Q13127 5978 4q12 human S1024-p 138107501 SDLSDNMsEGSDDSG protein degradation; ubiquitination 29156689 1 0 0 -Ngef ephexin-1 iso2 GEF; GEF, Rac/Rho Q8CHT1-2 53972 1 D|1 44.42 cM mouse Y87-p 455579 IEQIGLLyQEYRDKS cytoskeletal reorganization 20152127 4 0 2 disperse of AChR clusters -GTF2A1 GTF2A1 Transcription, coactivator/corepressor P52655 2957 14q31.1 human S280-p 449822 VDGTGDTsSEEDEDE TFIIA transcription, induced 11278496 1 0 0 -MRE11 MRE11A Cell cycle regulation; DNA repair, damage; DNA-binding; Deoxyribonuclease P49959 4361 11q21 human K480-ub 573764936 LVKYQLEkTQRFLKE activity, induced; ubiquitination DNA repair, induced 36563124 1 3 0 MRE11A promotes its exonuclease activity -NR1D1 NR1D1 Nuclear receptor; Transcription factor P20393 9572 17q21.1 human S59-p 471092 FPPSPTGsLTQDPAR protein stabilization 16484495 1 0 0 -ACSL4 ACSL4 EC 6.2.1.3; Ligase; Lipid Metabolism - fatty acid; Membrane protein, integral O60488 2182 Xq23 human S447-p 23079030 LSGGAPLsPQTHRFM AMP-binding protein degradation 37428466 1 5 2 inhibition of ACSL4-driven lipid peroxidation and ferroptosis is necessary for CDK1 to promote oxaliplatin resistance in CRC -SERINC3 SERINC3 Cell surface; Membrane protein, integral; Membrane protein, multi-pass Q13530 10955 20q13.12 human S383-p 1255792400 DTTTSGAsDEEDGQP Serinc molecular association, regulation AP1M1(INDUCES); AP2M1(INDUCES) 30135209 1 1 0 Mu subunits of AP-1 and AP-2 fused to MBP -SQSTM1 SQSTM1 Autophagy; Nuclear receptor co-regulator; Ubiquitin conjugating system Q13501 8878 5q35.3 human S366-p 476290 PESEGPSsLDPSQEG protein stabilization carcinogenesis, induced 31810986 2 25 5 -Cttn Cortactin Actin-binding; Cytoskeletal; Motility/polarity/chemotaxis NP_001385572 60465 1q41-q42 rat Y482-p 447704 YQAEDDTyDGYESDL cell adhesion, altered 15383621 25 1 3 -DRD2 DRD2 GPCR, family 1; Membrane protein, integral; Membrane protein, multi-pass; Receptor, GPCR P14416 1813 11q23.2 human K251-ub 1877221608 CTHPEDMkLCTVIMK 7tm_1 protein degradation 32572597 1 0 0 -Hsf1 HSF1 DNA-binding; Transcription factor F1MAF1 79245 7q34 rat K80-ac 6741100 LNMYGFRkVVHIEQG HSF_DNA-bind molecular association, regulation apoptosis, induced; transcription, inhibited DNA(DISRUPTS) 28547133 5 2 0 -KHDRBS1 KHDRBS1 RNA-binding Q07666 10657 1p35.2 human K96-sm 3755607 PSATASVkMEPENKY apoptosis, inhibited; transcription, inhibited 16568089 1 0 0 -HSPB1 HSP27 Chaperone; Heat shock protein; Motility/polarity/chemotaxis; SUMO LIGASE; SUMO ligase P04792 3315 7q11.23 human S82-p 448403 RALSRQLsSGVSEIR protein degradation; molecular association, regulation; phosphorylation; activity, induced; sumoylation; ubiquitination; intracellular localization; protein conformation carcinogenesis, induced; apoptosis, altered; cell motility, induced; signaling pathway regulation; transcription, altered; autophagy, induced; cell differentiation, induced; cell growth, induced; apoptosis, inhibited; cytoskeletal reorganization; transcription, inhibited; cell growth, altered TRAF6(DISRUPTS); TPM1(INDUCES); p53(INDUCES); HSF1(DISRUPTS); hnRNP D0(DISRUPTS); HSP27(DISRUPTS); Akt1(DISRUPTS) RNA(DISRUPTS) 11383510; 11912188; 12367505; 12740362; 14749215; 15581903; 18477563; 18950704; 19597476; 21245386; 21989268; 32570757; 34477462; 34498800; 34516752; 34851698; 35000271; 35499078; 36260112; 36701233 78 104 289 induces lysophagy -HDAC1 HDAC1 DEACETYLASE; Deacetylase; EC 3.5.1.98; Hydrolase; Nuclear receptor co-regulator Q13547 3065 1p35.2-p35.1 human K476-sm 2407422 KPEAKGVkEEVKLA_ cell cycle regulation; transcription, inhibited 11960997 3 3 0 -Creb1 CREB iso1 DNA-binding; Transcription factor P15337-1 81646 9q32 rat S142-p 448547 RKILNDLsSDAPGVP pKID molecular association, regulation; activity, inhibited transcription, inhibited CBP(DISRUPTS); CREB iso1(DISRUPTS) 11013247; 11970864; 9668047 11 20 2 -PPP1R12A MYPT1 Motility/polarity/chemotaxis; PHOSPHATASE; Protein phosphatase, regulatory subunit O14974 4659 12q21.2-q21.31 human T696-p 448587 ARQSRRStQGVTLTD enzymatic activity, inhibited; intracellular localization; phosphorylation cell motility, induced; cell growth, inhibited; cell differentiation, induced; cell adhesion, induced; cytoskeletal reorganization; signaling pathway regulation 16038801; 31834925; 33762326; 33802280; 35594862 66 42 226 -IL6ST gp130 Membrane protein, integral; Receptor, cytokine P40189 3572 5q11.2 human Y905-p 448182 DEGMPKSyLPQTVRQ cell cycle regulation; transcription, altered 10623831 3 4 16 -Egfr EGFR EC 2.7.10.1; KINASE; Kinase, protein; Membrane protein, integral; Oncoprotein; Protein kinase, TK; Protein kinase, tyrosine (receptor) Q01279 13649 11 A2|11 9.41 cM mouse S1070-p 448051 DAFLQRYsSDPTGAV carcinogenesis, induced 36624189 17 6 7 -SLC3A2 SLC3A2 Membrane protein, integral; Transporter P08195 6520 11q12.3 human S410-p 6003502 SYLSDSGsTGEHTKS cell adhesion, altered 19065266 1 0 0 enhances cell- cell interactions -H3C1 H3 DNA-binding P68431 8350 6p22.2 human K36-m2 1458610 APATGGVkKPHRYRP Histone molecular association, regulation; acetylation cell cycle regulation; carcinogenesis, induced; carcinogenesis, inhibited; cell differentiation, induced; chromatin organization, altered; transcription, induced; transcription, inhibited NBS1(INDUCES) 16732292; 17589499; 18923077; 20139424; 20417597; 20457893; 25823024; 32826945 44 18 7 decreases histone H3/H4 acetylation; hemin-mediated differentiation -RIGI RIGI EC 3.6.4.13; Hydrolase O95786 23586 9p21.1 human K96-sm 63243403 IESWDFKkIEKLEEY phosphorylation 28250012 1 0 0 dephosphorylation -KLF13 KLF13 C2H2-type zinc finger protein; DNA-binding Q9Y2Y9 51621 15q13.3 human K168-ac 460599 ESPQRKHkCHYAGCE zf-C2H2 molecular association, regulation DNA(DISRUPTS) 12758070 1 0 0 -SREBF1 SREBP-1 DNA-binding; Membrane protein, integral; Membrane protein, multi-pass; Transcription factor P36956 6720 17p11.2 human S338-p 458357 IEKRYRSsINDKIIE HLH molecular association, regulation transcription, inhibited SREBP-1(DISRUPTS) 16381800 4 1 0 inhibits lipogenesis -H3c1 H3 DNA-binding P68433 360198 13|13 A3.1 mouse K14-ac 458954 ARKSTGGkAPRKQLA Histone molecular association, regulation cell cycle regulation; endocytosis, altered; cell differentiation, induced; chromatin organization, altered; cell adhesion, altered; transcription, induced; transcription, altered DNA(INDUCES) 10899125; 17590163; 17823087; 18662547; 19109180; 19264835; 19707598; 19859561; 20129940; 20543957; 20574709; 20710121; 23341587; 33195484 162 31 355 modulates circadian rhythms; may be associated with gene expression; axon guidance -MRPL10 MRPL10 Mitochondrial; Ribosomal; Translation Q3MHY7 515014 cow K196-ac 12674404 QGFINYSkLPSLALA translation, induced 20042612 1 1 0 downregulates protein synthesis -Pak3 PAK3 EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, STE; Protein kinase, Ser/Thr (non-receptor) Q62829 29433 Xq33 rat T421-p 448126 PEQSKRStMVGTPYW Pkinase enzymatic activity, induced 11278486 3 2 11 -BLM BLM DNA repair, damage; DNA replication; EC 3.6.4.12; Helicase P54132 641 15q26.1 human T171-p 471430 ETSKSFVtPPQSHFV BLM_N protein degradation; molecular association, regulation; ubiquitination FBXW7(INDUCES) 26028025 1 8 8 -Nalcn VGCNL1 Channel, calcium; Membrane protein, integral; Membrane protein, multi-pass; Transporter, ion channel Q6Q760 266760 15q25 rat S1653-p 1869465802 TLSDRGGsRQDAADT activity, inhibited 31601786 1 0 0 VGCNL1 channel activity inhibited -TP53 p53 Activator; DNA-binding; Motility/polarity/chemotaxis; Nuclear receptor co-regulator; Transcription factor; Tumor suppressor P04637 7157 17p13.1 human K372-ne 12067100 HSSHLKSkKGQSTSR transcription, inhibited 15242646 1 0 0 -CHD4 CHD-4 DNA-binding; EC 3.6.4.12; Helicase Q14839 1108 12p13.31 human S428-p 470519 WEAKEDNsEGEEILE molecular association, regulation chromatin organization, altered; transcription, induced DNA(DISRUPTS); RNA(DISRUPTS) 29907651 1 44 0 -ARHGEF1 ARHGEF1 GEF; GEF, Rac/Rho; Motility/polarity/chemotaxis Q92888 9138 19q13.2 human Y738-p 13421400 WDQEAQIyELVAQTV PH_16 activity, induced 20098430 1 0 0 -KEAP1 KEAP1 Endoplasmic reticulum; Motility/polarity/chemotaxis; Transcription regulation; UBIQUITIN LIGASE; Ubiquitin conjugating system Q14145 9817 19p13.2 human S53-p 1410340102 QHGNRTFsYTLEDHT molecular association, regulation transcription, induced NRF2(DISRUPTS) 30576774 1 1 0 free NRF2 nuclear localization, NQO1, GCLC transcription induced -FCRL3 FCRL3 Adaptor/scaffold; Membrane protein, integral Q96P31 115352 1q23.1 human Y650-p 469980 PMELEPMySNVNPGD molecular association, regulation ZAP70(INDUCES) 12051764 1 0 0 -SLC25A4 SLC25A4 Membrane protein, integral; Membrane protein, multi-pass; Mitochondrial; Transporter; Transporter, SLC family P12235 291 4q35.1 human Y195-p 457913 RAAYFGVyDTAKGML Mito_carr; TM cell growth, altered 20007455 1 10 242 required for an efficient oxidative growth in yeast -RAB37 RAB37 G protein; G protein, monomeric; G protein, monomeric, Rab Q96AX2 326624 17q25.1 human T172-p 556476901 YGVPFLEtSAKTGMN Ras intracellular localization; activity, inhibited exocytosis, inhibited; cell motility, induced 29312551 1 0 0 eliminates TIMP1 secretion, promotes metastasis -ULK1 ULK1 Autophagy; EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, Other; Protein kinase, Ser/Thr (non-receptor) O75385 8408 12q24.33 human K607-ac 27850503 RNLRGSPkLPDFLQR enzymatic activity, induced apoptosis, induced 22539723 2 1 0 serum deprivation induced autophagy -DDAH2 DDAH2 Apoptosis; EC 3.5.3.18; Hydrolase O95865 23564 6p21.33 human T211-p 1872776104 DHPYASLtLPDDAAA intracellular localization; phosphorylation; enzymatic activity, induced signaling pathway regulation 33850055 1 1 0 regulates RLR signaling, regulates DRP1 anf IRF3 phosphorylation -PAK1 PAK1 EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, STE; Protein kinase, Ser/Thr (non-receptor) Q13153 5058 11q13.5-q14.1 human S223-p 454121 DVATSPIsPTENNTT activity, induced; intracellular localization; enzymatic activity, induced carcinogenesis, induced; cell motility, induced 23885116; 26160174 3 25 14 membrane localization; malignant transformation prostate -KCNA5 Kv1.5 Channel, potassium; Membrane protein, integral; Membrane protein, multi-pass P22460 3741 12p13.32 human K536-sm 3144801 HEEPAVLkEEQGTQS activity, induced 17261810 1 0 0 -AKAP5 AKAP5 Adaptor/scaffold P24588 9495 14q23.3 human S92-p 31878521 LVTRRKRsESSKQQK WSK molecular association, regulation ACTB(INDUCES) 29196604 1 1 0 AKAP5 de-palmitoylation, AKAP5 from dendritic spines -NOTCH1 Notch 1 Membrane protein, integral; Motility/polarity/chemotaxis; Oncoprotein; Receptor, misc.; Transcription factor P46531 4851 9q34.3 human S1791-p 27457604 REPLGEDsVGLKPLK protein degradation cell cycle regulation 31597699 1 2 0 promotes inflammatory cytokines secretion -Bcl2 Bcl-2 Apoptosis; Autophagy; Membrane protein, integral; Oncoprotein P49950 24224 13p11 rat S70-p 448395 RDTAARTsPLRPLVA apoptosis, altered 14572466; 15994315 49 1 0 -PTH1R PTHR GPCR, family 2; Membrane protein, integral; Membrane protein, multi-pass; Receptor, GPCR Q03431 5745 3p21.31 human S493-p 2853105 KARSGSSsYSYGPMV receptor internalization, induced; molecular association, regulation ARR3(INDUCES) 27623777 4 2 0 S503 AND T504 IN THE SECOND CLUSTER ARE RESPONSIBLE FOR 70% OF ARRESTIN3 RECRUITMENT -Cdc25a CDC25A EC 3.1.3.48; Motility/polarity/chemotaxis; PHOSPHATASE; Protein phosphatase, dual-specificity P48964 12530 9 F2|9 59.81 cM mouse S75-p 449340 SSLQRMGsSESTDSG protein degradation cell cycle regulation; apoptosis, altered 15928203 12 1 1 -PER2 PER2 Nuclear receptor co-regulator; Nucleolus; Transcription factor O15055 8864 2q37.3 human S662-p 449331 ALPGKAEsVASLTSQ protein degradation; protein stabilization; intracellular localization; phosphorylation transcription, induced 17218255; 21324900; 30425162 8 1 1 Phosphorylation of S662 promotes casein kinase I to phosphorylate nearby residues. CKI does not appear to phosphorlyate this residue (requires priming kinase). Phosphorylation increased period length (tau). Nonphosphorylated protein is mainly nuclear (as opposed to nuclear and cytoplasmic). Phosphorylated Per2 promotes its own transcription. -BARD1 BARD1 EC 6.3.2.-; EC 6.3.2.19; Ligase; UBIQUITIN LIGASE; Ubiquitin conjugating system; Ubiquitin ligase Q99728 580 2q35 human S251-p 455769 SQPSVISsPQINGEI cell cycle regulation 15855157 2 1 1 resistance to genotoxic stress (mitomycin C) -EIF4EBP1 4E-BP1 Translation; Translation initiation Q13541 1978 8p11.23 human S65-p 447527 FLMECRNsPVTKTPP eIF_4EBP molecular association, regulation; protein conformation; activity, inhibited; phosphorylation translation, altered; cell growth, induced; apoptosis, inhibited; translation, induced; translation, inhibited mTOR(DISRUPTS); EIF4E(DISRUPTS) 11553333; 15051500; 20880835; 21734039; 21914810; 22071574; 24247720; 25702871; 27065332; 34546793; 35626002 104 60 6 -RANBP9 RANBP9 Adaptor/scaffold; GAP; GAP, Ras; Nuclear receptor co-regulator Q96S59 10048 6p23 human S603-p 482142 TEMEVDSsQLRRQLC CTLH intracellular localization 26943034 1 1 0 nuclear accumulation -GAPDH GAPDH Carbohydrate Metabolism - glycolysis and gluconeogenesis; EC 1.2.1.12; Oxidoreductase P04406 2597 12p13.31 human Y42-p 450511 DPFIDLNyMVYMFQY Gp_dh_N intracellular localization DNA repair, induced; apoptosis, inhibited PKCI(INDUCES) 17488287; 32539222 2 1 4 -LATS1 LATS1 EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, AGC; Protein kinase, Ser/Thr (non-receptor); Tumor suppressor O95835 9113 6q25.1 human K830-sm 62518204 GFIHRDIkPDNILID Pkinase enzymatic activity, induced transcription, induced 27847303 1 0 0 -SOD1 SOD1 Apoptosis; EC 1.15.1.1; Mitochondrial; Nuclear receptor co-regulator; Oxidoreductase P00441 6647 21q22.11 human T40-p 1100571300 WGSIKGLtEGLHGFH Sod_Cu enzymatic activity, inhibited cell growth, inhibited 29727620; 35452786 2 0 0 modulate cellular ROS and maintain cancer survival in an ischemic environment; ischemia-induced cell death -CDC27 CDC27 Cell cycle regulation P30260 996 17q21.32 human S154-p 18258506 FLWSPFEsLCEIGEK cell growth, altered 21209074 1 0 0 regulates SnoN degradation -BEST1 BEST1 Channel, chloride; Membrane protein, integral; Membrane protein, multi-pass; Transporter; Transporter, ion channel O76090 7439 11q12.3 human S358-p 9720901 SAQFRRAsFMGSTFN activity, induced; molecular association, regulation; intracellular localization 14-3-3 gamma(INDUCES) 19635817; 29121962 2 0 0 glutamate release from hippocampal astrocyte; S358E mutation prevents channel rundown ; whole-cell current and surface expression of Best1 channel in astrocytes -PTEN PTEN Carbohydrate Metabolism - inositol phosphate; EC 3.1.3.16; EC 3.1.3.48; EC 3.1.3.67; Motility/polarity/chemotaxis; Nuclear receptor co-regulator; PHOSPHATASE; Phosphatase, lipid; Tumor suppressor P60484 5728 10q23.31 human K254-sm 28722900 LPVCGDIkVEFFHKQ PTEN_C2 protein stabilization; ubiquitination; intracellular localization cell cycle regulation; carcinogenesis, inhibited; apoptosis, induced; cell growth, inhibited 23888040; 24344134; 27506944; 27852060 4 1 0 -TPX2 TPX2 Cell cycle regulation; Microtubule-binding Q9ULW0 22974 20q11.21 human T320-p 626439300 KKRTFDEtVSTYVPL intracellular localization KPNB1(INDUCES) 29276125 1 1 0 accumulation of TPX2 at the prophase centrosome -MDM2 MDM2 EC 6.3.2.-; EC 6.3.2.19; Inhibitor; Ligase; NEDDYLATION LIGASE; Neddylation Ligase; Nucleolus; Oncoprotein; UBIQUITIN LIGASE; Ubiquitin conjugating system; Ubiquitin ligase Q00987 4193 12q15 human K182-ac 35480408 LSGERQRkRHKSDSI protein stabilization; molecular association, regulation; ubiquitination; intracellular localization; protein conformation apoptosis, inhibited; transcription, inhibited KPNA1(DISRUPTS); USP7(INDUCES) 28196907 1 0 0 decreases MDM2 self-ubiquitination, increases MDM2-ubiquitination activity toward p53 -SPAG5 SPAG5 Cell cycle regulation Q96R06 10615 17q11.2 human S135-p 460403 KTIVLVPsPLGQQQD intracellular localization cell cycle regulation 27325694 1 16 0 localization and formation of kinetochores -Carm1 CARM1 EC 2.1.1.125; METHYLTRANSFERASE; Methyltransferase; Methyltransferase, protein arginine; Nuclear receptor co-regulator Q9WVG6 59035 9|9 A3 mouse S229-p 486445 HAEVLVKsNNLTDRI PrmA molecular association, regulation; enzymatic activity, inhibited transcription, inhibited CARM1(DISRUPTS) 17640894 1 0 0 -GLI1 GLI1 C2H2-type zinc finger protein; Oncoprotein; Transcription factor P08151 2735 12q13.3 human T304-p 27708600 GEKPHKCtFEGCRKS cell growth, induced; transcription, induced DNA(INDUCES) 23446420 1 0 0 -Snca SNCA Adaptor/scaffold O55042 20617 6 B3|6 29.15 cM mouse S129-p 448278 SEAYEMPsEEGYQDY Synuclein receptor internalization, induced; protein stabilization; molecular association, regulation; intracellular localization endocytosis, induced; transcription, induced; transcription, altered ubiquitin(INDUCES); LAG3(INDUCES); APLP1(INDUCES) 17360705; 32024799; 33549656; 34092244; 34172566; 34326260; 35250825; 36966145; 37626586 143 7 0 induce neurodegeneration, promotes cell to cell transmission; regulates Nrf2 localization -Tpt1 TPT1 Calcium-binding; Microtubule-binding P63028 22070 14 D3|14 40.29 cM mouse S64-p 3146607 PEGEGTEsTVVTGVD TCTP cell cycle regulation; apoptosis, inhibited; cytoskeletal reorganization 12167714 4 1 0 -Fgd1 FGD1 GEF; GEF, misc. P52734 14163 X F3|X 68.46 cM mouse S205-p 3193805 LVPRAEAsTSSAAVS intracellular localization cytoskeletal reorganization 20045932 2 2 0 -Pak1 PAK1 EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, STE; Protein kinase, Ser/Thr (non-receptor) O88643 18479 7 E1|7 53.57 cM mouse S21-p 448174 APPMRNTsTMIGAGS activity, induced; molecular association, regulation; intracellular localization NCK1(DISRUPTS) 14585966 3 0 10 -Stat5b STAT5B DNA-binding; Oncoprotein; Transcription factor P42232 20851 11 D|11 63.63 cM mouse S730-p 448751 TYMDQAPsPVVCPQA activity, induced 12091337 14 0 0 -SHC4 SHC4 Adaptor/scaffold Q6S5L8 399694 15q21.1 human Y424-p 462715 NSKCSSVyENCLEQS molecular association, regulation GRB2(INDUCES); SHP-2(INDUCES) 17452444; 28213521 2 5 40 -DROSHA DROSHA EC 3.1.26.3; Nucleolus; RNA processing; RNA-binding; Ribonuclease Q9NRR4 29102 5p13.3 human S255-p 40274400 DRRERGRsPDRRRQD molecular association, regulation DGCR8(DISRUPTS) 25699712 1 1 0 -CD274 PD-L1 Membrane protein, integral Q9NZQ7 29126 9p24.1 human T194-p 1874101908 EEKLFNVtSTLRINT C2-set_2 O-GlcNAc glycosylation; protein stabilization; ubiquitination carcinogenesis, induced 34315872 1 0 0 inhibits ubiquitination -Egfr EGFR EC 2.7.10.1; KINASE; Kinase, protein; Membrane protein, integral; Oncoprotein; Protein kinase, TK; Protein kinase, tyrosine (receptor) Q01279 13649 11 A2|11 9.41 cM mouse Y1172-p 448059 MSLDNPDyQQDFFPK enzymatic activity, induced 16902180 44 60 967 -TTK TTK Cancer Testis Antigen (CTA); EC 2.7.12.1; KINASE; Kinase, protein; Protein kinase, Other; Protein kinase, dual-specificity (non-receptor) P33981 7272 6q14.1 human S362-p 13194902 TLKNKTEsSLLAKLE intracellular localization; enzymatic activity, induced 26119734 2 2 0 regulates spindle assembly checkpoint and recruitment of SAC proteins -NET1 NET1 GEF; GEF, Rac/Rho; Motility/polarity/chemotaxis; Oncoprotein Q7Z628 10276 10p15.1 human S100-p 3204288 RPLARVTsLANLISP protein stabilization 26456332 1 9 0 inhibits extracellular matrix degradation -Scn2a SCN2A Channel, sodium; Membrane protein, integral; Membrane protein, multi-pass P04775 24766 3q21 rat Y66-p 1046203 GKSLPFIyGDIPPEM molecular association, regulation; activity, inhibited Fyn(INDUCES) 17959797 1 0 0 -KCNIP3 calsenilin Calcium-binding; Transcription factor Q9Y2W7 30818 2q11.1 human S63-p 450214 APQGSDSsDSELELS protein processing 12837631 1 0 0 Phosphorylation of calsenilin at Ser-63 inhibits cleavage of the molecule by caspase-3. -TP73 p73 DNA-binding; Transcription factor; Tumor suppressor O15350 7161 1p36.32 human S48-p 52434701 VVGGTDSsMDVFHLE intracellular localization; activity, inhibited cell cycle regulation; apoptosis, induced; cell motility, induced; cell growth, induced; apoptosis, inhibited; transcription, inhibited 26625870; 26640387 2 1 0 -RB1 Rb Nuclear receptor co-regulator; Oncoprotein; Transcription, coactivator/corepressor; Tumor suppressor P06400 5925 13q14.2 human S758-p 1878197600 SIIVFYNsVFMQRLK molecular association, regulation; protein conformation carcinogenesis, induced; cell growth, induced; apoptosis, inhibited; transcription, inhibited NFkB-p65(DISRUPTS) 35950917 1 0 0 -Dtna DTNA Motility/polarity/chemotaxis Q9D2N4 13527 18 A2|18 12.08 cM mouse Y713-p 1869344404 TQPEDGNyENESVRQ protein stabilization; molecular association, regulation KAP(INDUCES) 32532815 1 0 0 -Slc5a5 SLC5A5 Membrane protein, integral; Membrane protein, multi-pass; Transporter; Transporter, SLC family Q63008 114613 16p14 rat S581-p 990309 DTATLEEsLVKGPED activity, induced 17913707 1 1 0 -RUVBL2 RUVBL2 EC 3.6.4.12; Helicase Q9Y230 10856 19q13.33 human K456-sm 12004420 AFLFNELkGETMDTS molecular association, regulation; intracellular localization chromatin organization, altered; transcription, inhibited HDAC1(INDUCES) 16699503 1 2 0 UBC9 levels were increased and SENP1 and SENP6 were decreased in metastatic cells. -Cacng2 Stargazin Channel, calcium; Membrane protein, integral; Membrane protein, multi-pass O88602 12300 15 E1|15 36.92 cM mouse S247-p 455319 SSRSTEPsHSRDASP activity, induced; intracellular localization 15664178; 20670832 3 0 0 AMPAR immobilization in synaptic membrane; enhances AMPA receptor responses and is required for long-term potentiation -CYP3A4 CYP3A4 Cell surface; Cofactor and Vitamin Metabolism - retinol; EC 1.14.14.1; Lipid Metabolism - linoleic acid; Membrane protein, integral; Oxidoreductase; Xenobiotic Metabolism - drug metabolism - cytochrome P450; Xenobiotic Metabolism - drug metabolism - other enzymes; Xenobiotic Metabolism - metabolism by cytochrome P450 P08684 1576 7q22.1 human S478-p 5938006 TQIPLKLsLGGLLQP p450 protein degradation; ubiquitination 19095658; 22101235; 25451919 3 2 0 -Ptk2 FAK EC 2.7.10.2; KINASE; Kinase, protein; Protein kinase, TK; Protein kinase, tyrosine (non-receptor) P34152 14083 15 D3|15 33.94 cM mouse Y397-p 447887 SVSETDDyAEIIDEE activity, induced; protein degradation; molecular association, regulation; intracellular localization; enzymatic activity, induced; phosphorylation cell cycle regulation; carcinogenesis, induced; cell motility, induced; cell adhesion, induced; cell adhesion, inhibited; signaling pathway regulation; cell growth, induced; cell motility, altered; cell growth, altered; transcription, induced; transcription, altered; neural plasticity; cell differentiation, induced; apoptosis, inhibited; cytoskeletal reorganization; cell adhesion, altered GRB2(INDUCES); P130Cas(INDUCES); Src(INDUCES); Src iso1(INDUCES); Arp3(DISRUPTS); SOCS3(INDUCES); SOCS1(INDUCES); PXN(INDUCES); SHC1(INDUCES) 10672902; 14517242; 16818654; 17721515; 19776009; 28348210; 32181337; 33730293; 33883558; 34475109; 34654724; 35525274; 35536885; 35538070; 36209205; 36438565; 36870331; 36997926; 37245640; 8816475; 9148935 371 31 474 -Glud1 GLUD1 Amino Acid Metabolism - alanine, aspartate and glutamate; Amino Acid Metabolism - arginine and proline; EC 1.4.1.3; Energy Metabolism - nitrogen; Mitochondrial; Other Amino Acids Metabolism - D-Glutamine and D-glutamate; Oxidoreductase P26443 14661 14 B|14 20.8 cM mouse Y135-p 3552510 SWEVIEGyRAQHSQH ELFV_dehydrog_N enzymatic activity, induced carcinogenesis, induced 36516759 1 3 50 -NGFR NGFR Membrane protein, integral; Receptor, misc. P18519 chicken S266-p 9993601 IAFKRWNsCKQNKQG TNFR_16_TM protein stabilization 19710323 1 1 0 -BNIP3 BNIP3 Membrane protein, integral; Mitochondrial Q12983 664 10q26.3 human T188-p 41388500 IYIGRRLtTSTSTF_ BNIP3 molecular association, regulation OPA1(DISRUPTS) 26102349 2 2 0 prevents mitochondrial damage, prevents cell death -SKAP2 SKAP2 Adaptor/scaffold O75563 8935 7p15.2 human Y75-p 449669 DAEDGEEyDDPFAGP protein conformation 21719704 2 4 3 -EPRS1 EPRS Aminoacyl-tRNA synthetase; Cofactor and Vitamin Metabolism - porphyrin and chlorophyll; EC 6.1.1.15; EC 6.1.1.17; Ligase; Translation; Translation regulation P07814 2058 1q41 human S886-p 452230 LSQSSDSsPTRNSEP molecular association, regulation; phosphorylation translation, altered; translation, inhibited NSAP1(INDUCES); GAPDH(INDUCES); RPL13A(INDUCES); NSAP1(DISRUPTS) 19647514; 21220307; 23071094 6 52 6 -Eif2ak1 HRI EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, Other; Protein kinase, Ser/Thr (non-receptor); Translation Q9Z2R9 15467 5|5 G2 mouse T490-p 447596 THTSRVGtCLYASPE Pkinase phosphorylation 12767237 1 0 0 -H3C1 H3 DNA-binding P68431 8350 6p22.2 human K9-m1 1458609 RTKQTARkSTGGKAP Histone molecular association, regulation; intracellular localization cell cycle regulation; cell differentiation, induced; chromatin organization, altered; transcription, induced; transcription, inhibited CHD-4(INDUCES) DNA(INDUCES) 16079795; 16732292; 18835819; 19021773; 19022177; 19624289; 19889207; 20548336; 20622854 34 19 14 -ITGB7 ITGB7 Cell adhesion; Membrane protein, integral; Motility/polarity/chemotaxis; Receptor, misc. P26010 3695 12q13.13 human Y758-p 469602 EIYDRREySRFEKEQ Integrin_b_cyt cell adhesion, altered 16874740 1 0 0 -POLB POLB DNA repair, damage; DNA replication; EC 2.7.7.7; Lyase; Transferase P06746 5423 8p11.21 human R83-m1 2363900 FLATGKLrKLEKIRQ DNA repair, induced 16600869 1 0 0 -CTBP1 CTBP1 Cell cycle regulation; EC 1.1.1.-; Nuclear receptor co-regulator; Oxidoreductase; Transcription, coactivator/corepressor Q13363 1487 4p16.3 human T144-p 2089802 LNLYRRAtWLHQALR 2-Hacid_dh; 2-Hacid_dh_C molecular association, regulation; protein conformation transcription, induced CTBP2(INDUCES); GCN5(DISRUPTS) 18184656 1 0 0 -Mastl MASTL EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, AGC; Protein kinase, Ser/Thr (non-receptor) Q8C0P0 67121 2|2 A3 mouse T193-p 3209097 NMMDILTtPSMSKPK Pkinase intracellular localization 24101512 2 3 0 export to the cytoplasm -AURKC AurC iso2 EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, Other; Protein kinase, Ser/Thr (non-receptor) Q9UQB9-2 6795 19q13.43 human T164-p 455456 TPSLRRKtMCGTLDY Pkinase enzymatic activity, induced 15670791 7 11 83 T164A mutant showed decreased kinase activity in vitro. -H2BC3 H2B DNA-binding P33778 3018 6p22.2 human K34-ub 10343623 KKRKRSRkESYSIYV Histone protein conformation chromatin organization, altered 35739357; 36112542 3 8 1 H2BK34ub induces a similar orientation and interaction pattern of Dot1L as H2BK120ub, direct interaction with Dot1L occurs with H2BK120ub; H2BK34ub induces DNA and histone distortion around the modified site.; widens the DNA gyre gap in the nucleosome, facilitates dinucleosome formation, stabilizes dinucleosome stacks; H2BK120-ub does not alter any of these properties -SNCA SNCA Adaptor/scaffold P37840 6622 4q22.1 human K102-sm 3829801 VKKDQLGkNEEGAPQ Synuclein ubiquitination apoptosis, inhibited 21746851; 29180403 5 1 0 -Rela NFkB-p65 DNA-binding; Nuclear receptor co-regulator; Transcription factor Q04207 19697 19 A|19 4.34 cM mouse K310-ac 459096 KRTYETFkSIMKKSP activity, induced; molecular association, regulation; intracellular localization cell differentiation, inhibited; transcription, induced; transcription, altered; signaling pathway regulation; chromatin organization, altered; cell differentiation, induced; apoptosis, inhibited; transcription, inhibited DNA(INDUCES); DNA(DISRUPTS) 17590163; 19103747; 19965984; 21900162; 23172686; 23555753; 23597856; 24013120; 24211200; 26226624; 26279947; 26799284; 26836609; 27507649; 30716535; 30736313; 33215396 84 5 0 -BCL10 Bcl-10 Apoptosis; Transcription, coactivator/corepressor; Tumor suppressor O95999 8915 1p22.3 human S218-p 469572 EEGTCANsSEMFLPL molecular association, regulation; intracellular localization Bcl-3(INDUCES) 16280327 3 0 0 -PAK6 PAK6 EC 2.7.11.1; KINASE; Kinase, protein; Nuclear receptor co-regulator; Protein kinase, STE; Protein kinase, Ser/Thr (non-receptor) Q9NQU5 56924 15q15.1 human S360-p 12099459 RTWHAQIsTSNLYLP molecular association, regulation; enzymatic activity, induced carcinogenesis, induced; cell motility, induced AR(INDUCES) 24130878 1 1 0 promotion of cell motility and invasion -SUCLA2 SCS-beta Carbohydrate Metabolism - citrate (TCA) cycle; Carbohydrate Metabolism - propanoate; EC 6.2.1.5; Ligase; Mitochondrial Q9P2R7 8803 13q14.2 human S79-p 27457818 PKGYVAKsPDEAYAI ATP-grasp_2 molecular association, regulation apoptosis, induced glutaminase(DISRUPTS) 33991485 1 6 0 -ESR1 ER-alpha DNA-binding; Nuclear receptor; Transcription factor P03372 2099 6q25.1-q25.2 human K302-ub 2134725 PLMIKRSkKNSLALS protein stabilization; activity, inhibited transcription, altered 19887647; 29100376 3 1 0 K302/303A mutants are more active then wt protein at low concentration of E2 -Atoh1 ATOH1 Cell development/differentiation; DNA-binding; Transcription factor P48985 11921 6 C1|6 30.03 cM mouse S328-p 34425604 QEDNSKTsPRSHRSD protein degradation; protein stabilization; molecular association, regulation; ubiquitination cell cycle regulation; cell growth, inhibited; cell differentiation, induced; transcription, inhibited HUWE1(INDUCES) 24960692; 34057742 3 2 0 -Mcu MCU Membrane protein, integral; Membrane protein, multi-pass; Mitochondrial Q3UMR5 215999 10|10 B4 mouse S56-p 27259016 TAHQRPAsWQSVGAA apoptosis, induced 23051746 2 0 0 increase CCDC109A current and myocardial cell death -PEBP1 RKIP Lipid-binding; Protein kinase, regulatory subunit P30086 5037 12q24.23 human T42-p 3189667 DELGKVLtPTQVKNR PBP protein degradation; molecular association, regulation cell cycle regulation; autophagy, induced; apoptosis, induced; signaling pathway regulation RAF1(DISRUPTS) 25104559 1 15 0 activation of the ERK pathway -TTK TTK Cancer Testis Antigen (CTA); EC 2.7.12.1; KINASE; Kinase, protein; Protein kinase, Other; Protein kinase, dual-specificity (non-receptor) P33981 7272 6q14.1 human S345-p 41157083 PLVSDEKsSELIITD intracellular localization; enzymatic activity, induced 26119734 1 1 0 regulates spindle assembly checkpoint and recruitment of SAC proteins -KCNJ1 ROMK Channel, potassium; Membrane protein, integral; Membrane protein, multi-pass P48048 3758 11q24.3 human S201-p 2813508 FSKNAVIsKRGGKLC IRK_C activity, induced; intracellular localization 12221079 3 0 1 -Gata1 GATA1 DNA-binding; Transcription factor P17679 14460 X A1.1|X 3.59 cM mouse S187-p 451237 LSSAAYSsPKFHGSL protein degradation; acetylation; ubiquitination; phosphorylation DNA(INDUCES) 16858405 3 0 0 Phosphorylation and acetylation cause the degradation of acetylated GATA-1; DNA binding is required for MAPK-dependent phosphorylation -TNFRSF1A TNF-R1 Membrane protein, integral; Receptor, cytokine P19438 7132 12p13.31 human T411-p 1868023606 LATWRRRtPRREATL Death molecular association, regulation; phosphorylation apoptosis, induced; signaling pathway regulation GRB2(DISRUPTS) 32159413 1 0 0 decrease ERK, Akt and STAT3 phosphorylation; non-canonical TNF-alpha signaling, necrosis induced -Eif2ak3 PERK EC 2.7.11.1; KINASE; Kinase, protein; Membrane protein, integral; Protein kinase, Other; Protein kinase, Ser/Thr (non-receptor); Translation Q9Z2B5 13666 6|6 C1 mouse T980-p 447936 MPAYATHtGQVGTKL Pkinase apoptosis, induced; translation, inhibited 34244887; 34647267 26 0 0 -FOXO1 FOXO1A DNA-binding; Nuclear receptor co-regulator; Oncoprotein; Transcription factor Q12778 2308 13q14.11 human R251-me 5009205 GKSGKSPrRRAASMD protein stabilization; intracellular localization; phosphorylation apoptosis, induced; transcription, induced 18951090 1 0 0 inhibits S256 phosphorylation -Wnk4 WNK4 EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, Other; Protein kinase, Ser/Thr (non-receptor) Q80UE6 69847 11|11 D mouse K384-ub 40323307 NAAQIYRkVTSGTKP Pkinase protein degradation 23576762 1 1 0 regulates electrolyte homeostasis and involved in Pseudohypoaldosteronism type II (PHAII) pathogenesis -Mlxipl ChREBP Transcription factor Q8VIP2 171078 12q12 rat S140-p 2103610 QYVQRRKsPVCGFVT molecular association, regulation; intracellular localization; activity, inhibited transcription, altered 14-3-3 beta(INDUCES); KPNA2(DISRUPTS) 18606808; 21665952 3 1 0 inhibits nuclear localization of ChREBP under low glucose conditions -BIN1 BIN1 Adaptor/scaffold; Cytoskeletal; Tumor suppressor; Vesicle O00499 274 2q14.3 human T348-p 7532308 VPPPPKHtPSKEVKQ molecular association, regulation; protein conformation signaling pathway regulation Tau(INDUCES) 31065832 1 7 4 Tau phosporylation-dependent interaction -Stxbp5 STXBP5 Vesicle Q8K400 78808 10|10 A1 mouse K285-sm 31957311 TPHGKQLkDGKKPEP LLGL neural plasticity 24614299 1 0 0 -Nos3 eNOS Amino Acid Metabolism - arginine and proline; EC 1.14.13.39; Oxidoreductase P70313 18127 5 A3|5 11.32 cM mouse T494-p 447885 AGITRKKtFKEVANA enzymatic activity, inhibited 34222255 82 2 1 -AKT1 Akt1 EC 2.7.11.1; KINASE; Kinase, protein; Oncoprotein; Protein kinase, AGC; Protein kinase, Ser/Thr (non-receptor) P31749 207 14q32.33 human Y176-p 14515900 EKATGRYyAMKILKK Pkinase intracellular localization; enzymatic activity, induced cell cycle regulation; transcription, altered 20333297 3 1 0 membrane localization -USP13 USP13 DEUBIQUITINASE; EC 3.4.19.12; Protease; Ubiquitin conjugating system; Ubiquitin-specific protease Q92995 8975 3q26.33 human Y708-p 1868989003 EPLTMPGyGGAASAG UCH molecular association, regulation carcinogenesis, induced; cell growth, induced; transcription, induced; signaling pathway regulation Myc(INDUCES) 32453420 1 1 0 inhibits ubiquitination and stabilizes c-Myc, regulates CLK3/USP13/c-Myc signaling -POLI POLI DNA repair, damage; EC 2.7.7.7; Transferase Q9UNA4 11201 18q21.2 human K511-ub 21181888 LDTTNFSkEKDINEF protein degradation 26370087 1 3 0 -UBA52-RPS27A-UBB-UBC ubiquitin Ubiquitin-like modifier P62991 mouse K27-ub 3931595 SDTIENVkAKIQDKE ubiquitin protein degradation; ubiquitination cell cycle regulation; autophagy, induced; cell growth, inhibited; transcription, inhibited 31127032; 35900990 30 23 142 USP22 promotes the degradation of NLRP3 via ATG5-mediated autophagy; impairs NFAT recruitment and transcription of NFAT-targeted genes -HDAC8 HDAC8 DEACETYLASE; Deacetylase; EC 3.5.1.98; Hydrolase Q9BY41 55869 Xq13.1 human S39-p 450667 AKIPKRAsMVHSLIE Hist_deacetyl acetylation; enzymatic activity, inhibited; protein conformation 14701748; 15242608; 31633931 3 0 2 Crystalographic data suggests how phosphorylation of S39 alters conformation and negatively regulate HDAC8 activity.; regulates deacetylation -KCNC4 Kv3.4 Channel, potassium; Membrane protein, integral; Membrane protein, multi-pass Q03721 3749 1p13.3 human S8-p 451075 MISSVCVsSYRGRKS Potassium_chann receptor inactivation, altered 9649584 1 1 0 -PRKAA1 AMPKA1 Autophagy; EC 2.7.11.1; EC 2.7.11.26; EC 2.7.11.27; EC 2.7.11.31; KINASE; Kinase, protein; Protein kinase, CAMK; Protein kinase, Ser/Thr (non-receptor) Q13131 5562 5p13.1 human S467-p 7445995 LQLYQVDsRTYLLDF AdenylateSensor enzymatic activity, inhibited; phosphorylation carcinogenesis, induced; cell motility, induced; cell growth, induced 31358902 1 2 0 inhibits phosphorylation at T172 -Cat Catalase Amino Acid Metabolism - tryptophan; Apoptosis; EC 1.11.1.6; Endoplasmic reticulum; Energy Metabolism - methane; Hydrolase; Mitochondrial; Oxidoreductase P24270 12359 2 E2|2 54.43 cM mouse Y231-p 450444 NADGEAVyCKFHYKT Catalase protein degradation; enzymatic activity, induced 12950161 2 9 310 -Lat2 LAB Adaptor/scaffold; Membrane protein, integral Q9JHL0 56743 5|5 G2 mouse Y192-p 450646 SPDEEPDyVNGDVAA LAT2 signaling pathway regulation 22308309 3 1 6 plays a negative role in TCR and FcRI-mediated and no role in LPS-mediated signaling -SIRT2 SIRT2 iso2 DEACETYLASE; Deacetylase; EC 3.5.1.- Q8IXJ6-2 22933 19q13.2 human K340-sm 1881502501 KKSPPPAkDEARTTE enzymatic activity, inhibited carcinogenesis, inhibited 33316537 1 0 0 SIRT2 is the deacetylase of P38 and its enzyme activity is inhibited by its SUMOylation, SUMOylation inhibits the carcinogenic phenotype in neurblastoma cells and is a tumor suppressor in mice -SNAP25 SNAP-25 Vesicle P60880 6616 20p12.2 human S187-p 448668 RIMEKADsNKTRIDE activity, induced; molecular association, regulation exocytosis, altered; exocytosis, induced SYT1(DISRUPTS); STX1A(INDUCES) 17325194; 18171919; 22311984 15 1 0 -GJA8 GJA8 Channel, misc.; Membrane protein, integral; Membrane protein, multi-pass P36381 395846 chicken S395-p 9824606 KASSRARsDDLTV__ activity, induced 21454606 1 2 0 enhances Cx50 gap junction coupling -TIRAP TIRAP Adaptor/scaffold P58753 114609 11q24.2 human Y187-p 463810 SGLSRAAyPPELRFM TIR_2 activity, induced; molecular association, regulation; phosphorylation transcription, induced TLR4(DISRUPTS); MYD88(DISRUPTS); Btk(INDUCES); P38A(INDUCES) 16439361; 18070880; 35379857 3 0 0 -TNIK TNIK EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, STE; Protein kinase, Ser/Thr (non-receptor) Q9UKE5 23043 3q26.2-q26.31 human S764-p 451976 RTRVRANsKSEGSPV activity, induced; intracellular localization cell growth, induced; transcription, induced 20530691; 30901730 2 23 23 -FOXO1 FOXO1A DNA-binding; Nuclear receptor co-regulator; Oncoprotein; Transcription factor Q12778 2308 13q14.11 human S416-p 478368 PPNTSLNsPSPNYQK intracellular localization transcription, altered 20061393 4 1 0 multiple site mutant (8A) -JUP CTNNG Cytoskeletal; Motility/polarity/chemotaxis P14923 3728 17q21.2 human Y133-p 456971 AIVHLINyQDDAELA molecular association, regulation transcription, induced TCF4(DISRUPTS); CTNNA1(DISRUPTS); Desmoplakin(INDUCES) 14517306 1 1 1 -Mip AQP0 Channel, misc.; Membrane protein, integral; Membrane protein, multi-pass; Transporter, aquaporin family P51180 17339 10 D3|10 76.49 cM mouse S235-p 450116 KSVSERLsILKGARP molecular association, regulation Calmodulin(DISRUPTS) 22095752 6 9 0 -TAGLN TAGLN Actin-binding; Motility/polarity/chemotaxis; Nuclear receptor co-regulator Q01995 6876 11q23.3 human K108-ub 1881229501 AEDYGVIkTDMFQTV protein degradation; ubiquitination 33771884 1 0 0 -Irs1 IRS1 Adaptor/scaffold; Motility/polarity/chemotaxis P35569 16367 1 C5|1 42.0 cM mouse S408-p 454417 CLFPRRSsASVSGSP activity, inhibited 15485932 3 0 0 -STAT1 STAT1 DNA-binding; Transcription factor P42224 6772 2q32.2 human R31-m1 476759 DSFPMEIrQYLAQWL STAT_int molecular association, regulation transcription, induced; transcription, altered PIAS1(DISRUPTS); PTPN2(INDUCES) 11257227; 12171910 2 0 0 modulates the duration of STAT1 Y701 phosphorylation -PKD2 PKD2 Channel, cation; Membrane protein, integral; Membrane protein, multi-pass Q13563 5311 4q22.1 human S801-p 15702202 SSLPRPMsSRSFPRS activity, induced cell cycle regulation 20881056 2 0 0 regulates ATP-induced calcium release -Pcbp1 hnRNP E1 RNA splicing; RNA-binding; Translation P60335 23983 6|6 D1 mouse S43-p 13258708 VKRIREEsGARINIS KH_1 translation, altered EEF1A1(DISRUPTS) 20154680; 21329880 3 0 3 -H4c2 H4 DNA-binding P62806 326620 13|13 A3.1 mouse R3-m2 477687 _____SGrGKGGKGL chromatin organization, altered; transcription, inhibited 17967893 10 2 0 -Zc3hc1 NIPA Cell cycle regulation; Ubiquitin conjugating system Q80YV2 232679 6|6 A3.3 mouse S358-p 483339 TRSWESSsPVDRPEL molecular association, regulation cell cycle regulation CUL1(DISRUPTS) 22955283 2 24 11 ERK2 phosphorylation at G2/M is sufficient dissociation of SCF core complex at G2/M. -SIRT3 SIRT3 DEACETYLASE; Deacetylase; EC 3.5.1.-; Mitochondrial Q9NTG7 23410 11p15.5 human T150-p 41655507 MVGAGIStPSGIPDF SIR2 enzymatic activity, induced apoptosis, inhibited 26141949 1 0 0 -Crmp1 CRMP-1 Cell development/differentiation; Cytoskeletal; Hydrolase P97427 12933 5 B3|5 19.96 cM mouse S522-p 1295503 PAPSAKSsPSKHQPP phosphorylation 29758318 4 12 7 S522A KI mice -Ctcf CTCF C2H2-type zinc finger protein; Transcription factor; Tumor suppressor Q61164 13018 8|8 D3 mouse K74-sm 6124703 DPTLLQMkTEVMEGT transcription, inhibited 19029252 2 1 0 -Map1s BPY2-IP1 Apoptosis; Microtubule-binding Q8C052 270058 8|8 B3.3 mouse S812-p 476391 GDRNRPLsARSEPAD cytoskeletal reorganization 30266824 3 6 0 inhibit microtubule binding -CNGA1 CNGA1 Channel, cation; Membrane protein, integral; Membrane protein, multi-pass Q00194 281700 cow Y498-p 450319 LKLQPQVySPGDYIC cNMP_binding activity, inhibited; protein conformation 10366613; 23032687 3 0 0 Phosphorylation promotes channel opening.; inhibits channel activity -HBP1 HBP1 DNA-binding; Transcription factor O60381 26959 7q22.3 human K297-ac 25171015 GLLTVECkLDHPFYV AXH transcription, inhibited 23249948 2 0 0 acetylation of the five sites induces transcriptional repression of the DNMT1 gene, regulates cellular senescence -Prkcg PKCG EC 2.7.11.13; KINASE; Kinase, protein; Protein kinase, AGC; Protein kinase, Ser/Thr (non-receptor) P63318 18752 7 A1|7 1.93 cM mouse T514-p 451041 FPGSTTRtFCGTPDY Pkinase intracellular localization; phosphorylation; enzymatic activity, induced exocytosis, induced 27531930; 35977516 6 45 45 -CUX1 CUTL1 DNA-binding; Membrane protein, integral; Transcription factor P39880 1523 7q22.1 human S1215-p 460700 AYMKRRHsSVSDSQP molecular association, regulation cell motility, altered; transcription, inhibited DNA(DISRUPTS) 16574653 2 4 6 -Traf1 TRAF1 Adaptor/scaffold; Apoptosis P39428 22029 2|2 B mouse S139-p 26331402 MALERNLsELQLQAA molecular association, regulation signaling pathway regulation TNF-R2(INDUCES); TBK1(DISRUPTS) 18429822; 23376065 2 0 0 TNF-R2 regulation of IKK and JNK pathways; regulates association of TBK1 with TNFRSF9 and NFkB activation -Ripk1 RIPK1 EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, Ser/Thr (non-receptor); Protein kinase, TKL Q60855 19766 13 A3.3|13 14.01 cM mouse S334-p 4728178 VPLPPSRsNSEQPGS molecular association, regulation; enzymatic activity, induced RIPK3(INDUCES) 28842570 2 3 0 necroptosis -MBD4 MBD4 Apoptosis; DNA repair, damage; Deoxyribonuclease; EC 3.2.2.- O95243 8930 3q21.3 human S165-p 22730001 CSMAALTsHLQNQSN enzymatic activity, induced DNA repair, induced 19829383 1 0 0 -RPA1 RPA1 DNA-binding P27694 6117 17p13.3 human S384-p 3189442 AIKGARVsDFGGRSL REPA_OB_2 molecular association, regulation cell cycle regulation; apoptosis, inhibited SHFM1(INDUCES) DNA(DISRUPTS) 37230964 1 18 4 -ACACA ACC1 Carbohydrate Metabolism - propanoate; Carbohydrate Metabolism - pyruvate; EC 6.3.4.14; EC 6.4.1.2; Ligase; Lipid Metabolism - fatty acid biosynthesis Q13085 31 17q12 human S1263-p 463821 FSDSPPQsPTFPEAG ACC_central molecular association, regulation; enzymatic activity, inhibited; protein conformation; phosphorylation BRCA1(INDUCES) 16698035; 19061860; 29899443 2 18 2 -Stat5b STAT5B DNA-binding; Oncoprotein; Transcription factor P52632 25126 10q31 rat Y699-p 448198 TAKAADGyVKPQIKQ molecular association, regulation; intracellular localization DNA(INDUCES) 12621061 45 45 2242 -H3c1 H3 DNA-binding P68433 360198 13|13 A3.1 mouse K27-m2 1308912 LATKAARkSAPATGG Histone endocytosis, altered; chromatin organization, altered; cell adhesion, altered; transcription, inhibited 16682010; 16717091; 18039862; 19567879; 20561915; 33195484 42 21 7 axon guidance -NHERF2 NHERF-2 Adaptor/scaffold Q15599 9351 16p13.3 human S303-p 9765067 QESGLHLsPTAAEAK EBP50_C molecular association, regulation; intracellular localization signaling pathway regulation Ezrin(DISRUPTS) 26251448; 26310448 2 10 0 -SRPK1 SRPK1 EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, CMGC; Protein kinase, Ser/Thr (non-receptor) Q96SB4 6732 6p21.31 human S408-p 1872827400 QNGDSSTsQETDSCT intracellular localization 33808326 1 0 0 -SMYD3 SMYD3 EC 2.1.1.43; METHYLTRANSFERASE; Methyltransferase; Methyltransferase, protein lysine; UBIQUITIN LIGASE; Ubiquitin ligase Q9H7B4 64754 1q44 human Y239-p 4145500 GEELTICyLDMLMTS SET methylation; enzymatic activity, induced 16805913 1 0 0 induces histone methylation -MYC Myc DNA-binding; Nucleolus; Oncoprotein; Transcription factor P01106 4609 8q24.21 human K332-ac 458889 AAPPSTRkDYPAAKR Myc_N molecular association, regulation ZBTB17(INDUCES) 16126174 2 2 0 induces association with ZBTB17 on specific target promoters -Tbk1 TBK1 EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, Other; Protein kinase, Ser/Thr (non-receptor) Q9WUN2 56480 10|10 D2 mouse K241-ac 56403910 MYKIITGkPSGAISG Pkinase enzymatic activity, inhibited 27240213 2 2 0 -NEDD1 NEDD1 Cell cycle regulation Q8NHV4 121441 12q23.1 human S377-p 12737836 EKAGLPRsINTDTLS intracellular localization cytoskeletal reorganization 22818914 2 6 0 recruitment of NEDD1 and gamma-tubulin to the centrosome during mitosis -Fbxo43 FBX43 Unknown function Q8CDI2 78803 15|15 B3.1 mouse T176-p 13419500 FSQHKTStIEDSKDN molecular association, regulation PLK1(INDUCES) 26459104 2 0 0 meiotic maturation -EIF2AK2 PKR EC 2.7.10.2; EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, Other; Protein kinase, Ser/Thr (non-receptor); Protein kinase, tyrosine (non-receptor); Translation P19525 5610 2p22.2 human Y162-p 458272 QLAAKLAyLQILSEE dsrm enzymatic activity, induced translation, altered; cell growth, altered 16373505 1 0 0 -RAPH1 RAPH1 Adaptor/scaffold; Motility/polarity/chemotaxis Q70E73 65059 2q33.2 human Y366-p 54363504 LFKNPQNyLLGKKET RA molecular association, regulation cell motility, induced 26996666 1 0 0 Lpd-Scar/WAVE interaction is positively regulated by c-Abl and c-Src, breast cancer cell invasion -Runx2 AML3 iso5 DNA-binding; Transcription factor Q08775-5 12393 17 B3|17 21.33 cM mouse K240-ub 1873375614 EPRRHRQkLDDSKPS cell differentiation, induced; transcription, induced 28500134 1 0 0 -RUNX1 AML1 DNA-binding; Oncoprotein; Transcription factor Q01196 861 21q22.12 human K43-ub 22081854 AGAALAGkLRSGDRS protein degradation; molecular association, regulation; intracellular localization carcinogenesis, inhibited; cell growth, inhibited; transcription, altered; transcription, inhibited TAF1(INDUCES) 28536267; 31664040 2 6 0 deposition of AML1-ETO at a subset of AE target genes and allows AE to control its target gene expression. -FLII FLI Actin-binding; Nuclear receptor co-regulator Q13045 2314 17p11.2 human T818-p 25787600 LHRPRHAtVSRSLEG Gelsolin transcription, induced 19293151 2 0 0 may induce transcription of the estrogen receptor -RACK1 RACK1 Adaptor/scaffold; G protein; G protein, heterotrimeric; G protein, heterotrimeric beta; Motility/polarity/chemotaxis; Nuclear receptor co-regulator P63244 10399 5q35.3 human Y228-p 450543 LNEGKHLyTLDGGDI WD40 protein stabilization; molecular association, regulation; ubiquitination; intracellular localization carcinogenesis, inhibited; cell adhesion, induced; cell motility, inhibited; endocytosis, inhibited Src(NOT_REPORTED) 12400005; 21685945 3 2 4 decreases phosphorylation of E-cadherin, B-catenin, p120 catenin and actin and localises them to cell-to-cell contacts, prevents ubiquitination of E-cadherin further inducing its stabilization, inhibits E-cadherin endocytosis -Mtor mTOR Autophagy; EC 2.7.11.1; KINASE; Kinase, protein; Motility/polarity/chemotaxis; Protein kinase, Ser/Thr (non-receptor); Protein kinase, atypical Q9JLN9 56717 4 E2|4 78.76 cM mouse S2159-p 20473601 RIQSIAPsLQVITSK phosphorylation; enzymatic activity, induced signaling pathway regulation 34245780 3 1 1 induces AKT phosphorylation and mTORC2 and 1 signaling -Cacna1c CACNA1C Channel, calcium; Membrane protein, integral; Membrane protein, multi-pass Q01815 12288 6 F1|6 55.86 cM mouse S1897-p 455278 ASLGRRAsFHLECLK CAC1F_C activity, induced; molecular association, regulation; activity, inhibited; phosphorylation ADRB2(DISRUPTS); CACNA1C(INDUCES) 27103070; 36345826 31 3 0 -AKR1C1 AKR1C1 EC 1.1.1.112; EC 1.1.1.149; EC 1.3.1.20; Oxidoreductase; Xenobiotic Metabolism - metabolism by cytochrome P450 Q04828 1645 10p15.1 human K185-ub 12386310 NKPGLKYkPVCNQVE Aldo_ket_red molecular association, regulation carcinogenesis, induced; cell motility, induced; transcription, induced STAT3(INDUCES) 32104503 1 3 7 pro-metastatic, induces transcription of metastasis-related target genes (SOX2 and TWIST) -Ntrk2 TrkB EC 2.7.10.1; KINASE; Kinase, protein; Membrane protein, integral; Protein kinase, TK; Protein kinase, tyrosine (receptor) P15209 18212 13 B1|13 31.2 cM mouse Y433-p 1872544500 NREHLSVyAVVVIAS molecular association, regulation; intracellular localization neural plasticity; signaling pathway regulation TrkB(INDUCES); Fyn(INDUCES) Other(INDUCES) 33606976 1 0 0 induces binding to cholesterol and fluoxetine, induces BDNF signaling -Pld1 PLD1 iso2 EC 3.1.4.4; Lipid Metabolism - ether lipid; Lipid Metabolism - glycerophospholipid; Motility/polarity/chemotaxis; Phospholipase P70496-2 25096 2q24 rat S2-p 448572 ______MsLRSEARV enzymatic activity, induced 10441128; 10788479 4 2 0 -Mapkapk5 MAPKAPK5 EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, CAMK; Protein kinase, Ser/Thr (non-receptor); Tumor suppressor O54992 17165 5|5 F mouse S115-p 18704700 GELFHRIsQHRHFTE Pkinase protein stabilization; molecular association, regulation; intracellular localization transcription, induced; signaling pathway regulation ERK3(INDUCES) 32139423 2 0 0 induces Atg1 expression, regulates ERK3/MK5 pathway -JAK3 JAK3 EC 2.7.10.2; KINASE; Kinase, protein; Protein kinase, TK; Protein kinase, tyrosine (non-receptor) P52333 3718 19p13.11 human Y785-p 450358 NSLISSDyELLSDPT molecular association, regulation SH2-B-beta(INDUCES) 15121872 3 11 63 -NDE1 NUDE1 iso1 Cell cycle regulation; Cytoskeletal; Microtubule-binding Q9NXR1-1 54820 16p13.11 human T243-p 469634 LDDSTGGtPLTPAAR NUDE_C molecular association, regulation; intracellular localization ZNF365(DISRUPTS) 16682949 1 11 16 -CXCR4 CXCR4 GPCR, family 1; Membrane protein, integral; Membrane protein, multi-pass; Receptor, GPCR P61073 7852 2q22.1 human S325-p 3849622 TSVSRGSsLKILSKG receptor desensitization, induced; receptor internalization, induced; protein degradation; molecular association, regulation; enzymatic activity, induced; activity, induced; ubiquitination; intracellular localization endocytosis, induced ITCH(INDUCES) 19116316; 30327409; 30936203; 34973340 11 12 6 -Cttn Cortactin Actin-binding; Cytoskeletal; Motility/polarity/chemotaxis Q60598 13043 7|7 F5 mouse Y499-p 57807005 TAIALYDyQAAGDDE SH3_9 molecular association, regulation MTUS2(DISRUPTS) 27451391 2 0 0 Y497, Y499, Y541 are major residues for interaction -DCK DCK EC 2.7.1.74; Kinase, other; Nucleotide Metabolism - purine; Nucleotide Metabolism - pyrimidine P27707 1633 4q13.3 human S15-p 460586 SCPSFSAsSEGTRIK phosphorylation 20544527 4 8 6 regulates phosphorylation of S74 -Itgb1 ITGB1 Cell adhesion; Cell surface; Membrane protein, integral; Motility/polarity/chemotaxis; Receptor, misc. P09055 16412 8|8 E2 mouse T788-p 448600 PIYKSAVtTVVNPKY Integrin_b_cyt molecular association, regulation; activity, inhibited exocytosis, induced; cell growth, induced; cell differentiation, induced; cytoskeletal reorganization; cell adhesion, altered; transcription, altered; cell adhesion, inhibited FN1(DISRUPTS); kindlin-2(DISRUPTS); SNX17(DISRUPTS) 19555977; 24719112; 34996844; 35090553; 9512507 15 2 1 The TT788-9AA mutant is defective in mediating cell attachment and does not contribute to fibronectin fibril formation. -Il6st gp130 Membrane protein, integral; Receptor, cytokine Q00560 16195 13 D2.2|13 63.73 cM mouse Y812-p 450054 EILPRQPyFKQNCSQ transcription, altered; signaling pathway regulation 36947594 3 0 1 regulates Src and MAPK/ERK signaling -RRN3 TIF1A Nucleolus; Transcription initiation complex Q9NYV6 54700 16p13.11 human S635-p 11315000 DTHFRSPsSSVGSPP activity, inhibited transcription, inhibited; transcription, altered TAF1C(DISRUPTS) 19815529; 28835357 2 2 0 inhibits transcription complex formation; suppresses pre-rRNA synthesis, protects against ER stress and cell death -SPRED1 SPRED1 Inhibitor Q7Z699 161742 15q14 human S105-p 36131862 KFGLTFQsPADARAF WH1 molecular association, regulation carcinogenesis, induced; cell growth, induced; signaling pathway regulation NF1(DISRUPTS) 32697994 1 2 0 regulates Ras-GTP signaling -Nkx3-2 NKX3-2 Cell development/differentiation; DNA-binding; Transcription factor P97503 12020 5 B3|5 22.58 cM mouse S148-p 20473603 EAPVRSDsEMSASVS molecular association, regulation; ubiquitination apoptosis, inhibited BTRC(INDUCES) 21606193 1 1 0 phosphorylation of S148/S168 causes ubiquitination of IkB-alpha. -Hoxb13 HOXB13 DNA-binding; Transcription factor P70321 15408 11 D|11 59.63 cM mouse S204-p 25295063 KAAFAEPsVQHPPPD intracellular localization cell cycle regulation; cell growth, altered 32499640 1 0 1 -RBBP8 CtIP EC 3.1.-.-; Transcription, coactivator/corepressor Q99708 5932 18q11.2 human S745-p 448392 SCLADSFsQAADEEE molecular association, regulation; enzymatic activity, induced BRCA1(DISRUPTS) 10910365; 24837676 2 1 2 -TOB1 TOB1 Adaptor/scaffold; Cell cycle regulation P50616 10140 17q21.33 human T172-p 1869290800 PTFMPRStQPLTFTT carcinogenesis, induced; cell motility, induced; cell growth, induced 31497236 1 1 0 -AGO2 AGO2 EC 3.1.26.n2; RNA processing; RNA-binding Q9UKV8 27161 8q24.3 human S834-p 40509024 GSHTSGQsNGRDHQA molecular association, regulation; activity, inhibited transcription, inhibited RNA(DISRUPTS) 28114302 2 2 0 regulates miRNA silencing -BANF1 BAF DNA-binding O75531 8815 11q13.1 human K6-sm 1877203102 __MTTSQkHRDFVAE BAF molecular association, regulation; intracellular localization cell cycle regulation lamin A/C(INDUCES); PCNA(INDUCES) DNA(INDUCES) 32332162 1 0 0 nuclear localization -SAFB SAFB1 DNA-binding; Nuclear receptor co-regulator; RNA-binding Q15424 6294 19p13.3 human K294-sm 9859930 DSLLAVVkREPAEQP molecular association, regulation transcription, inhibited HDAC3(INDUCES) 21527249 1 6 0 -RRN3 TIF1A Nucleolus; Transcription initiation complex Q9NYV6 54700 16p13.11 human S636-p 50680600 THFRSPSsSVGSPPV intracellular localization 26506235 1 0 0 nuclear localization -ELK3 ELK3 DNA-binding; Transcription factor P41970 2004 12q23.1 human K162-sm 3818700 PDAFKAIkTEKLEEP transcription, inhibited 15580297 1 1 0 -NF1 NF1 iso2 GAP; GAP, Ras; Motility/polarity/chemotaxis; Nucleolus; Tumor suppressor P21359-2 4763 17q11.2 human S2808-p 456895 QKQRSAGsFKRNSIK intracellular localization 26490262 1 8 10 Ran-dependent -Olig2 OLIG2 Oncoprotein; Transcription factor Q9EQW6 50913 16 C3.3|16 52.6 cM mouse S13-p 18357900 SLVSSRPsSPEPDDL cell cycle regulation; cell differentiation, altered; carcinogenesis, altered; cell growth, induced; apoptosis, inhibited; transcription, induced; cell motility, inhibited 21382551; 27396340; 32483381 4 2 0 -Cttn Cortactin Actin-binding; Cytoskeletal; Motility/polarity/chemotaxis Q60598 13043 7|7 F5 mouse S407-p 467687 QTPPASPsPQPIEDR cell cycle regulation; cell motility, altered 18515860 0 22 19 -NF2 Merlin Cytoskeletal; Motility/polarity/chemotaxis; Tumor suppressor P35240 4771 22q12.2 human T230-p 487468 AIRNKKGtELLLGVD FERM_C protein degradation; phosphorylation carcinogenesis, induced; cell motility, induced; cell growth, induced 17891137; 21750658 4 1 0 induces phosphorylation at S518 -WT1 WT1 C2H2-type zinc finger protein; DNA-binding; Nucleolus; Transcription factor; Tumor suppressor P19544 7490 11p13 human S365-p 451117 KDCERRFsRSDQLKR zf-C2H2 transcription, altered 9366517 1 0 0 Phosphorylation of S365 inhibited WT1 DNA-binding, and thereby decreased WT1 transcriptional repression activity. -DCC DCC Immunoglobulin superfamily; Membrane protein, integral; Receptor, misc.; Tumor suppressor P43146 1630 18q21.2 human Y1363-p 1979800 AIEPKVPyTPLLSQP Neogenin_C molecular association, regulation RASA1(INDUCES); Lck(INDUCES); Fyn(INDUCES) 18253061; 26710849 2 0 0 -CASQ2 calsequestrin 2 Calcium-binding P12637 483134 dog S405-p 1868253001 DEESNDDsDDDDE__ intracellular localization 21431367 2 1 0 regulates intracellular trafficking of calsequestrin 2 -LATS2 LATS2 EC 2.7.11.1; KINASE; Kinase, protein; Nuclear receptor co-regulator; Protein kinase, AGC; Protein kinase, Ser/Thr (non-receptor); Tumor suppressor Q9NRM7 26524 13q12.11 human S835-p 28706304 GSHVRQDsMEPSDLW Pkinase activity, induced; phosphorylation; enzymatic activity, induced apoptosis, induced; signaling pathway regulation 23886938; 30800215 2 1 0 Hippo pathway; Chk1-dependent trans-autophosphorylation in SAS cell line; in SAS cell line; enhances p21Cip1 phosphoylation -OTULIN FAM105B EC 3.4.19.12 Q96BN8 90268 5p15.2 human Y56-p 3560103 AEHEEDMyRAADEIE molecular association, regulation carcinogenesis, induced; transcription, induced; signaling pathway regulation; transcription, inhibited RNF31(DISRUPTS); CTNNB1(INDUCES) 24726323; 24726327; 32770022 3 3 20 Wnt/?-catenin pathway -WDCP WDCP Q9H6R7 80304 2p23.3 human S695-p 31855763 SHSPGAVsSLKVFTG molecular association, regulation KIF2A(DISRUPTS); MRE11A(INDUCES) 30297404 1 2 0 mitotic spindle dynamics -SOD2 SOD2 EC 1.15.1.1; Mitochondrial; Oxidoreductase P04179 6648 6q25.3 human K122-ac 475813 GELLEAIkRDFGSFD Sod_Fe_C enzymatic activity, inhibited 28584055 9 6 68 regulates NLRP3 inflammasome assembly formation and activation, cytokine production -ATG16L1 ATG16L1 Adaptor/scaffold; Autophagy; Membrane protein, peripheral Q676U5 55054 2q37.1 human T300-p 54390606 VPQDNVDtHPGSGKE protein stabilization; intracellular localization autophagy, induced 31267703 2 0 0 induces xenophagy -Cpeb1 CPEB RNA-binding; Translation P70166 12877 7|7 D3 mouse T171-p 449610 VRGSRLDtRPILDSR CEBP1_N molecular association, regulation neural plasticity; translation, altered; cytoskeletal reorganization; translation, induced PARN(DISRUPTS) 17567800; 22727665 8 0 0 spine density and shape, long-term depression and motor coordination ; PARN release, polyadenylation -TMIGD2 IGPR-1 Membrane protein, integral Q96BF3 126259 19p13.3 human S220-p 14160579 GKDQRGQsIYSTSFP protein conformation; phosphorylation autophagy, induced; cell growth, induced; cell adhesion, induced; apoptosis, inhibited; cytoskeletal reorganization 27838321; 28920928; 31341021; 32978258 4 2 19 determines the sensitivity of tumor cells to the killing effects of doxorubicin; Blocking the trans-homophilic dimerization of IGPR-1 inhibits IGPR-1 S220 phosphorylation.; inhibition of shear stress?induced actin fiber assembly and endothelial cell remodeling; phosphorylation/activation of AMPK, BECN1 and ULK1 -Oaz2 OAZ2 Inhibitor O08608 18247 9|9 C mouse S186-p 11507801 YPLDQNLsDED____ molecular association, regulation ODC(INDUCES) 19725046 1 0 0 -SENP3 SENP3 DESUMOYLASE; EC 3.4.22.68; Nucleolus; Protease; Sumo-specific protease Q9H4L4 26168 17p13.1 human S139-p 36438204 AFRMLLYsKSTSLTF molecular association, regulation; intracellular localization NPM1(INDUCES) 25288641 1 1 0 ribosome biogenesis-28S rRNA maturation -Ckm CKM Amino Acid Metabolism - arginine and proline; EC 2.7.3.2; KINASE; Kinase, other P00564 24265 1q21 rat S128-p 5410301 LDPNYVLsSRVRTGR activity, inhibited 18979206 1 3 0 -EGFR EGFR EC 2.7.10.1; KINASE; Kinase, protein; Membrane protein, integral; Oncoprotein; Protein kinase, TK; Protein kinase, tyrosine (receptor) P00533 1956 7p11.2 human Y727-p 457949 SGAFGTVyKGLWIPE PK_Tyr_Ser-Thr molecular association, regulation SHC1(INDUCES) 16729043 2 15 150 -MC4R MC4R GPCR, family 1; Membrane protein, integral; Membrane protein, multi-pass; Receptor, GPCR P32245 4160 18q21.32 human S330-p 449103 GGLCDLSsRY_____ receptor internalization, altered 12639913 2 0 0 -ESR1 ER-alpha DNA-binding; Nuclear receptor; Transcription factor P03372 2099 6q25.1-q25.2 human K302-ac 459091 PLMIKRSkKNSLALS activity, induced transcription, altered 11279135 2 0 0 suppresses ligand sensitivity -RHOT1 RHOT1 EC 3.6.5.-; G protein; G protein, monomeric; G protein, monomeric, Rho; Hydrolase; Membrane protein, integral; Mitochondrial Q8IXI2 55288 17q11.2 human K187-ub 7287869 EMKPACIkALTRIFK protein degradation; intracellular localization autophagy, induced 34152608 1 8 9 induces mitophagy by recruiting Parkin to mitochondria -SMAD2 SMAD2 DNA-binding; Transcription factor Q15796 4087 18q21.1 human S240-p 450145 SDQQLNQsMDTGSPA molecular association, regulation; intracellular localization SMAD3(INDUCES) 11027280; 11879191 2 0 0 S240-p translocates to the nucleus. -Ppargc1a PGC-1 alpha Nuclear receptor co-regulator; Transcription, coactivator/corepressor O70343 19017 5|5 C1 mouse S241-p 13861602 KCASKKKsHTQPQSQ protein stabilization; intracellular localization transcription, induced 20351112; 23201126 2 0 0 -Lipe HSL EC 3.1.1.79; Lipase P54310 16890 7 A3|7 13.78 cM mouse S651-p 450195 GFHPRRSsQGVLHMP Abhydrolase_3 activity, induced; intracellular localization; enzymatic activity, induced 21186937; 24273196; 30126894; 33888116 29 14 16 -NR3C1 GR DNA-binding; Mitochondrial; Nuclear receptor; Transcription factor P04150 2908 5q31.3 human K495-ac 3287301 LEARKTKkKIKGIQQ receptor desensitization, induced; molecular association, regulation transcription, induced; transcription, inhibited NFkB-p65(DISRUPTS) DNA(DISRUPTS) 16380507; 19141540 2 0 0 -Sfn 14-3-3 sigma Adaptor/scaffold O70456 55948 4 D2.3|4 66.25 cM mouse S186-p 456054 FHYEIANsPEEAISL 14-3-3 molecular association, regulation Abl(DISRUPTS) 19220809 5 0 0 -Tsc2 TSC2 Cell cycle regulation; GAP; GAP, misc.; Nuclear receptor co-regulator; Tumor suppressor Q61037 22084 17 A3.3|17 12.41 cM mouse T1465-p 448546 GLRPRGYtISDSAPS activity, inhibited; enzymatic activity, induced 36842323 64 14 48 induces mTORC1 activity -MAP2K6 MKK6 EC 2.7.12.2; KINASE; Kinase, protein; Protein kinase, STE; Protein kinase, dual-specificity (non-receptor) P52564 5608 17q24.3 human Y219-p 1186001 IDAGCKPyMAPERIN Pkinase molecular association, regulation RAC1(INDUCES) 17854274 1 0 0 enhances Rac-GTPase activity and inhibits NADPH oxidase activity in vivo -NEDD9 Cas-L Adaptor/scaffold; Motility/polarity/chemotaxis Q14511 4739 6p24.2 human S369-p 9471800 VDGINRLsFSSTGST protein degradation cell motility, inhibited FAK(DISRUPTS) 19539609; 25817040 2 2 0 -ACE ACE EC 3.4.15.1; Membrane protein, integral; Protease P12821 1636 17q23.3 human S1299-p 450699 SHGPQFGsEVELRHS protein degradation; molecular association, regulation; intracellular localization; phosphorylation exocytosis, altered; transcription, induced ACE(INDUCES); MYH9(INDUCES) DNA(INDUCES) 12386153; 14615289; 15569856; 16186248; 16476786; 21901117 7 17 15 -PAX8 PAX8 Transcription factor Q06710 7849 2q14.1 human T277-p 1877752106 TLDDGKAtLTPSNTP protein stabilization 31391550 1 0 0 -Mvk MVK EC 2.7.1.36; Kinase, other; RNA-binding; Secondary Metabolites Metabolism - terpenoid backbone biosynthesis; Translation P17256 rat K256-sm 12723514 GVRSRLIkFPEIMAP translation, inhibited 20167237 1 0 0 -HBP1 HBP1 DNA-binding; Transcription factor O60381 26959 7q22.3 human K398-ub 573758320 FARSGFSkNCGSPGS protein degradation carcinogenesis, induced; cell growth, induced; transcription, induced; DNA repair, inhibited 30816344 1 3 0 MDM2-induced genomic instability by ubiquitinating HBP -THRA TR-alpha iso2 DNA-binding; Nuclear receptor; Transcription factor P10827-2 7067 17q21.1 human K283-sm 27490404 LSGEMAVkREQLKNG Hormone_recep cell growth, induced; cell differentiation, induced; transcription, induced; signaling pathway regulation 25572392 4 0 0 induces Wnt/?-catenin signaling pathway -WEE1 Wee1 EC 2.7.10.2; KINASE; Kinase, protein; Protein kinase, Other; Protein kinase, Ser/Thr (non-receptor); Protein kinase, tyrosine (non-receptor) P30291 7465 11p15.4 human S139-p 449250 YFLGSSFsPVRCGGP protein degradation; molecular association, regulation; phosphorylation cell cycle regulation PLK1(INDUCES) 23051732 1 28 2 primes PLK1 phosphorylation -PACSIN2 PACSIN2 Adaptor/scaffold; Motility/polarity/chemotaxis Q9UNF0 11252 22q13.2 human S313-p 4786393 ADLNRTLsRREKKKA molecular association, regulation; ubiquitination cell motility, induced; cytoskeletal reorganization; transcription, inhibited 31801866; 37296607 3 7 20 NS5A protein from Hepatitis C virus inhibits phosphorylation of this site which promotes its interaction with PACSIN2 domain I; inhibits ubiquitination and degradation of N-WASP -Ptpn6 SHP-1 EC 3.1.3.48; Motility/polarity/chemotaxis; PHOSPHATASE; Protein phosphatase, tyrosine (non-receptor) P29351 15170 6 F2|6 59.17 cM mouse Y208-p 3712666 EASGAFVyLRQPYYA protein processing 18617527 1 0 0 promotes N terminal cleavage to 45 kDa form -NFATC4 NFAT3 DNA-binding; Transcription factor Q14934 4776 14q12 human S213-p 953804 ASRFGLGsPLPSPRA transcription, induced 17875713 1 13 1 -Map2k1 MEK1 EC 2.7.12.2; KINASE; Kinase, protein; Protein kinase, STE; Protein kinase, dual-specificity (non-receptor) Q01986 170851 8q24 rat T286-p 448286 VEGDAAEtPPRPRTP Pkinase enzymatic activity, inhibited 8114697 8 6 16 -NOTCH1 Notch 1 Membrane protein, integral; Motility/polarity/chemotaxis; Oncoprotein; Receptor, misc.; Transcription factor P46531 4851 9q34.3 human S2439-p 1875193400 SFLSGEPsQADVQPL protein degradation cell cycle regulation 31597699 1 0 0 -Prkd1 PRKD1 Autophagy; EC 2.7.11.13; KINASE; Kinase, protein; Motility/polarity/chemotaxis; Protein kinase, CAMK; Protein kinase, Ser/Thr (non-receptor) Q9WTQ1 85421 6q22 rat S916-p 447632 KALSERVsIL_____ molecular association, regulation; intracellular localization autophagy, induced; transcription, altered KIDINS220(DISRUPTS) 16651260; 18378685; 35760846 43 13 0 induces mitophagy; Pasteurella multocida toxin induced nuclear localization and CREB transactivation -Foxo3 FOXO3A Autophagy; DNA-binding; Oncoprotein; Transcription factor Q9WVH4 56484 10 B2|10 22.79 cM mouse S314-p 449109 DFRSRTNsNASTVSG intracellular localization carcinogenesis, induced; cell growth, induced 12857750; 33795838 5 0 1 -FOXC2 FOXC2 Apoptosis; Cell development/differentiation; DNA-binding; Transcription factor Q99958 2303 16q24.1 human S232-p 3210579 ITKVETLsPESALQG molecular association, regulation transcription, altered DNA(INDUCES) 23878394 1 18 0 implicated in vascular remodeling in vivo -RET Ret EC 2.7.10.1; KINASE; Kinase, protein; Membrane protein, integral; Oncoprotein; Protein kinase, TK; Protein kinase, tyrosine (receptor) P07949 5979 10q11.21 human Y809-p 450701 LIVEYAKyGSLRGFL PK_Tyr_Ser-Thr enzymatic activity, induced cell growth, altered 14711813 2 0 0 -Sort1 SORT1 Membrane protein, integral; Receptor, misc. Q6PHU5 20661 3|3 F2.3-F3 mouse S819-p 468808 KSGYHDDsDEDLLE_ protein stabilization; intracellular localization 28844948 5 43 23 plasma membrane localization -DDX5 DDX5 EC 3.6.4.13; Helicase; Nuclear receptor co-regulator; Nucleolus; RNA splicing; RNA-binding; Spliceosome P17844 1655 17q23.3 human K44-ac 15211502 PGEKLVKkKWNLDEL protein stabilization; molecular association, regulation carcinogenesis, induced; transcription, induced HDAC1(INDUCES); HDAC2(INDUCES) 20663877 1 1 0 -BAG3 BAG3 Apoptosis; Chaperone O95817 9531 10q26.11 human T285-p 467534 GSPARSStPLHSPSP molecular association, regulation; intracellular localization cell cycle regulation; cytoskeletal reorganization HSBP1(DISRUPTS) 27659916; 34685619 2 40 63 -Ptpn1 PTP1B EC 3.1.3.48; Motility/polarity/chemotaxis; PHOSPHATASE; Phosphatase; Protein phosphatase, tyrosine (non-receptor) P20417 24697 3q42 rat Y152-p 449312 ISEDVKSyYTVRQLE Y_phosphatase phosphorylation cell differentiation, inhibited; cell motility, inhibited; transcription, altered; signaling pathway regulation 33511306 5 0 1 Regulates bone regeneration; inhibits phosphorylation of FAK, STAT3, inhibits NOTCH signaling -WRN WRN Cell cycle regulation; DNA repair, damage; DNA-binding; EC 3.6.4.12; Helicase; Nucleolus Q14191 7486 8p12 human K1127-ac 14512100 SGSNISKkSIMVQSP protein stabilization; ubiquitination 20428248 1 1 0 inhibits ubiquitination -IRF5 IRF5 DNA-binding; Transcription factor Q13568 3663 7q32.1 human K412-ub 4666600 DRKPREKkLITVQVV IRF-3 molecular association, regulation; ubiquitination; intracellular localization transcription, induced; transcription, inhibited LYN(INDUCES) 18824541; 27521268 2 1 0 pro-inflammatory cytokine gene transcription; nuclear translocation; inhibition of IRF5 activation by Lyn requires their physical Interaction, Lyn inhibits IRF5 ubiquitination and phosphorylation by protecting IRF5 from each of PTM enzymes -EEF1A1 EEF1A1 Nucleolus; Translation; Translation elongation P68104 1915 6q13 human S21-p 5434136 GHVDSGKsTTTGHLI GTP_EFTU protein degradation; molecular association, regulation; ubiquitination apoptosis, induced EEF1A2(INDUCES) 22378069 1 4 5 -MCM7 MCM7 DNA replication; EC 3.6.4.12; Motility/polarity/chemotaxis P33993 4176 7q22.1 human K449-m2 58123200 CCIDEFDkMAEADRT MCM molecular association, regulation L3MBTL iso4(INDUCES) 23583077 0 1 0 -ATAD5 ATAD5 Q96QE3 79915 17q11.2 human S653-p 3209715 TVPFDSEsPIRMKFT molecular association, regulation BRD4(DISRUPTS) 31875566 1 8 0 -BRAF BRAF EC 2.7.11.1; KINASE; Kinase, protein; Oncoprotein; Protein kinase, Ser/Thr (non-receptor); Protein kinase, TKL P15056 673 7q34 human K578-ub 40212808 SIIHRDLkSNNIFLH PK_Tyr_Ser-Thr carcinogenesis, induced; cell growth, induced; transcription, induced 23907581 1 0 0 phosphorylation at T599 and S602 and K578 ubiquitination mediate ERK activation -MED1 MED1 Nuclear receptor co-regulator; Transcription, coactivator/corepressor Q15648 5469 17q12 human T1457-p 449866 HSKSPAYtPQNLDSE activity, induced; molecular association, regulation; protein stabilization; intracellular localization; phosphorylation carcinogenesis, induced; cell growth, induced; apoptosis, inhibited; transcription, induced; signaling pathway regulation FOXA1(INDUCES); AR(INDUCES) 16314496; 23850489; 25481872; 31466944 7 2 0 increased UBE2C protein expression; induces phosphorylation of itself at T1032 and of AR, regulates AR signaling -Fbxo43 FBX43 Unknown function Q8CDI2 78803 15|15 B3.1 mouse T152-p 50613404 FSPLVTStIKTEDVV molecular association, regulation PLK1(INDUCES) 26459104 1 0 0 meiotic maturation -PDGFC PDGFC Secreted; Secreted, signal peptide Q9NRA1 56034 4q32.1 human K314-sm 3875800 EVLQLRPkTGVRGLH PDGF molecular association, regulation; intracellular localization DNA(INDUCES) 16443219 1 0 0 nuclear localization -TSPYL2 TSPYL2 DNA replication; Transcription regulation Q9H2G4 64061 Xp11.22 human T340-p 12559513 GRLVSHStPIRWHRG NAP cell growth, altered 11395479 1 0 0 -RAD52 RAD52 DNA repair, damage P43351 5893 12p13.33 human K274-ac 971232904 QFRERMEkQQVRVST molecular association, regulation; intracellular localization DNA repair, induced RFA2(INDUCES); RPA3(INDUCES); RAD51(INDUCES); RPA1(INDUCES) 29590107 1 1 0 accumulation of RAD52 at DSB sites -Mecp2 MECP2 Transcription, coactivator/corepressor Q9Z2D6 17257 X A7.3|X 37.63 cM mouse S80-p 452713 AVPEASAsPKQRRSI activity, induced apoptosis, altered; chromatin organization, altered; cell growth, induced; transcription, induced; transcription, altered 19225110; 19820693; 31352003 12 68 1 HSC activation induced; HSC proliferation and collagen expression; Regulation of Liver fibrosis -GALNT2 GALNT2 EC 2.4.1.41; Glycan Metabolism - O-glycan biosynthesis; Membrane protein, integral; Transferase Q10471 2590 1q42.13 human K111-ac 25336503 FNQVESDkLRMDRAI enzymatic activity, inhibited; O-GalNAc glycosylation 21651894 0 1 0 inhibits glycosylation of mucin -Gli2 GLI2 C2H2-type zinc finger protein; Oncoprotein; Transcription factor Q0VGT2 14633 1 E2.3|1 52.17 cM mouse S805-p 1717566 YTVSRRSsGISPYFS sumoylation 22549777 1 5 3 -PLD2 PLD2 EC 3.1.4.4; Lipid Metabolism - ether lipid; Lipid Metabolism - glycerophospholipid; Motility/polarity/chemotaxis; Phospholipase O14939 5338 17p13.2 human Y511-p 10036100 FFWLGKDySNLITKD molecular association, regulation; enzymatic activity, induced cell growth, altered GRB2(INDUCES); CD45(DISRUPTS) 19715678; 20176813 2 1 0 dephosphorylated Y179 and Y511 mediates an induction of cell proliferation -CCDC6 CCDC6 Apoptosis; Cytoskeletal; Oncoprotein Q16204 8030 10q21.2 human S413-p 4957370 SHGITRPsPRRSNSP protein degradation; molecular association, regulation cell cycle regulation FBXW7(INDUCES) 23108047; 25885523 2 7 3 -AMBRA1 AMBRA1 Autophagy; UBIQUITIN LIGASE; Ubiquitin ligase; Vesicle Q9C0C7 55626 11p11.2 human S1043-p 1255792404 CRPEALNsGVEYYWD protein stabilization; molecular association, regulation; protein conformation autophagy, induced LC3B(INDUCES); GABARAP(INDUCES) 30217973 1 0 0 mitophagy induced interaction -KHDRBS1 KHDRBS1 RNA-binding Q07666 10657 1p35.2 human S20-p 457016 RSSGRSGsMDPSGAH neural plasticity; RNA splicing, induced 37595869 2 49 11 -MAPKAPK5 MAPKAPK5 EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, CAMK; Protein kinase, Ser/Thr (non-receptor); Tumor suppressor Q8IW41 8550 12q24.12-q24.13 human S160-p 1876193500 NLLFKDNsLDAPVKL Pkinase enzymatic activity, induced 35064619 1 1 0 -PAK4 PAK4 EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, STE; Protein kinase, Ser/Thr (non-receptor) O96013 10298 19q13.2 human K473-me 1876978900 SKEVPRRkSLVGTPY Pkinase intracellular localization cytoskeletal reorganization; cell motility, inhibited; cell adhesion, inhibited 33051544 1 0 0 decreases formation of filopodia and actin structures, inhibits paxillin localization to focal adhesions, inhibits invasion -Prkca PKCA EC 2.7.11.13; KINASE; Kinase, protein; Oncoprotein; Protein kinase, AGC; Protein kinase, Ser/Thr (non-receptor) P20444 18750 11 E1|11 70.8 cM mouse Y658-p 455927 SDFEGFSyVNPQFVH Pkinase_C molecular association, regulation GRB2(INDUCES) 12881490 5 0 0 -RRAS RRas G protein; G protein, monomeric; G protein, monomeric, Ras; Motility/polarity/chemotaxis P10301 6237 19q13.33 human Y66-p 448122 DPTIEDSyTKICSVD Ras molecular association, regulation cell motility, altered; cytoskeletal reorganization; cell adhesion, altered 10570155; 11682467; 16522685 3 0 0 Y66E blocks activated (38V) R-Ras-induced cell retraction (cells with spikes). Y66F blocks activated R-Ras inhibition of cell migration during ephrin-B1 stimulation (effect present but not as intense in Y66F non-activated R-ras allele). Y66F inhibits ephrin-A1-induced growth cone collapse. -Myocd myocardin Cell development/differentiation; Transcription factor Q8VIM5 214384 11|11 B3 mouse S466-p 3627506 PPISPASsDLSAAGS transcription, inhibited 16141410 1 0 0 -PIAS4 PIAS4 EC 6.3.2.-; Nuclear receptor co-regulator; SUMO LIGASE; SUMO conjugating system; SUMO ligase; Transcription, coactivator/corepressor Q8N2W9 51588 19p13.3 human K35-sm 2293702 GRSKSGLkHELVTRA sumoylation; molecular association, regulation; intracellular localization transcription, induced PML(DISRUPTS) 15831457 1 0 0 induces sumoylation of Tcf-4 -LIG1 LIG1 DNA repair, damage; EC 6.5.1.1; Ligase P18858 3978 19q13.33 human K79-ub 59175203 DEALSPAkGQKPALD protein degradation 27573245 1 1 0 -YBX1 YB-1 RNA processing; RNA splicing; RNA-binding; Transcription factor P67809 4904 1p34.2 human S209-p 7998039 YGRRPQYsNPPVQGE molecular association, regulation; intracellular localization carcinogenesis, induced; cell growth, induced; transcription, induced; signaling pathway regulation DNA(INDUCES) 35008856; 37328464 2 14 25 induces the TOPK/YB1/eEF1A1 signal pathway; prevent nuclear translocation and nuclear import -Plk4 PLK4 EC 2.7.11.21; KINASE; Kinase, protein; Nucleolus; Protein kinase, Other; Protein kinase, Ser/Thr (non-receptor) Q64702 20873 3|3 B mouse T300-p 12654006 TITASSGtSLSGSLL protein degradation; ubiquitination 20100909 2 1 0 -Stx3 STX3 iso2 Cell adhesion; Membrane protein, integral; Vesicle Q64704-2 20908 19|19 A mouse T14-p 31960301 QLKAKQLtQDDDTDE molecular association, regulation; protein conformation exocytosis, induced SNAP-25(INDUCES) 24680688 5 1 0 shift to open conformation-regulates neurotransmitter release efficiency -MYOD1 MyoD DNA-binding; RNA splicing; Transcription factor P15172 4654 11p15.1 human S200-p 452000 YSGDSDAsSPRSNCS Myf5 molecular association, regulation; activity, inhibited transcription, inhibited SUV39H1(INDUCES) DNA(INDUCES) 20026657 1 1 0 MyoD binding to SUV39H1 results in SUV39H1 binding to DNA. -ACTB ACTB Cytoskeletal; Motility/polarity/chemotaxis P60709 60 7p22.1 human S239-p 3147240 SSSSLEKsYELPDGQ Actin phosphorylation cell motility, induced; cell growth, inhibited; cytoskeletal reorganization 37648284 1 25 1 inhibits Rac1/Cdc42 phosphorylation -MAVS MAVS Adaptor/scaffold; Membrane protein, integral Q7Z434 57506 20p13 human S324-gl 1872691002 ASVSTVPsKLPTSSK phosphorylation 31461653 1 1 0 positively regulates phosphorylation of S442 (data from MAVS 7A mutant) -NFKBIB IkB-beta Inhibitor Q15653 4793 19q13.2 human S23-p 447916 WCDSGLGsLGPDAAA protein degradation 8657102 6 0 0 -RACGAP1 MgcRacGAP GAP; GAP, Rac/Rho Q9H0H5 29127 12q13.12 human S170-p 459865 ESLDWDSsLVKTFKL molecular association, regulation; enzymatic activity, induced cell cycle regulation PPP2CA(DISRUPTS) 19468302; 27453045; 35477750 5 4 0 induces Rho GTPase activity -Tsc2 TSC2 Cell cycle regulation; GAP; GAP, misc.; Nuclear receptor co-regulator; Tumor suppressor P49816 24855 10q12 rat T1373-p 469994 SSEGARPtVDLSFQP activity, inhibited; phosphorylation translation, altered; apoptosis, inhibited 16959574 3 11 26 inhibits mTOR signaling. required for Wnt-3a to stimulation phosphorylation of S6K and 4EBP1 and increase protein levels of cyclin D1 and VEGF (cyclin D1 through translation not transcription). -ABRAXAS1 Abraxas DNA repair, damage Q6UWZ7 84142 4q21.23 human S404-p 25173562 MKGFGEYsRSPTF__ molecular association, regulation BRCA1(INDUCES) 26778126 2 6 0 -GMPS GMPS EC 6.3.5.2; Ligase; Nucleotide Metabolism - purine; Oncoprotein; Xenobiotic Metabolism - drug metabolism - other enzymes P49915 8833 3q25.31 human K182-ub 4332244 AGIANESkKLYGAQF GATase intracellular localization apoptosis, inhibited 24462112 1 6 41 -NAA50 NAA50 ACETYLTRANSFERASE; Acetyltransferase; EC 2.3.1.- Q9GZZ1 80218 3q13.31 human K140-ac 475616 ETKKNYYkRIEPADA acetylation; enzymatic activity, induced 19744929 1 1 25 reduces histone acetylation and increases NAT activity, thereby increasing enzyme specificity -Atm ATM DNA repair, damage; EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, Ser/Thr (non-receptor); Protein kinase, atypical; Tumor suppressor Q62388 11920 9 A5.3|9 29.12 cM mouse S1987-p 448797 SPTFEEGsQGTTISS intracellular localization; enzymatic activity, induced DNA repair, induced; chromatin organization, altered 16906133; 17244605; 19047460; 25101980; 33753455 214 24 4 -STAT4 STAT4 DNA-binding; Transcription factor Q14765 6775 2q32.2-q32.3 human S713-p 50800612 SDSTEPHsPSDLLPM molecular association, regulation; enzymatic activity, inhibited transcription, inhibited LIFR(DISRUPTS) 30770344 1 3 0 inhibits STAT3 activity -KCNA3 Kv1.3 Channel, potassium; Membrane protein, integral; Membrane protein, multi-pass P22001 3738 1p13.3 human Y162-p 3820931 SFDAILYyYQSGGRI BTB_2 activity, inhibited 19166614 1 0 0 -Prlr PRLR Membrane protein, integral; Receptor, cytokine Q08501 19116 15 A1|15 5.23 cM mouse Y532-p 3188101 VPETSKEyAKVSGVT molecular association, regulation transcription, altered CISH(INDUCES) 12761205 1 0 0 binding of CISH inhibits STAT5 activation (STAT5 does not bind to this site though) -PSME3 PSME3 Nuclear receptor co-regulator; Protease; Proteasome complex P61289 10197 17q21.31 human S247-p 15413789 EKIKRPRsSNAETLY PA28_beta molecular association, regulation apoptosis, induced DBC-1(INDUCES) 25361978 1 1 0 inhibits SIRT1 to induce phosphorylation of PSME3 -Smarca2 SMARCA2 EC 3.6.1.-; EC 3.6.4.-; Helicase; Nuclear receptor co-regulator; Transcription, coactivator/corepressor Q6DIC0 67155 19 C1|19 21.17 cM mouse K1542-ac 460622 GRDTGKGkKRPNRGK molecular association, regulation; protein conformation cell growth, induced; transcription, inhibited Rb(DISRUPTS) DNA(DISRUPTS) 14657023 1 1 1 -Cap1 CAP1 Actin-binding; Cytoskeletal P40124 12331 4|4 D2.2 mouse S307-p 485063 SAPKPQTsPSPKPAT molecular association, regulation; intracellular localization cytoskeletal reorganization; cell motility, inhibited Cofilin-1(DISRUPTS); ACTA1(INDUCES) 25315833 4 46 29 -Epor EPOR Membrane protein, integral; Receptor, cytokine P14753 13857 9 A3|9 7.93 cM mouse Y425-p 449884 TSPSSFEyTILDPSS molecular association, regulation CISH(INDUCES) 28038963 10 0 0 -Caskin1 CASKIN1 Adaptor/scaffold Q8VHK2 140722 10q12 rat S1258-p 481277 VPLPGPGsPEVKRAH signaling pathway regulation 30411139 0 24 0 -MCL1 MCL1 Apoptosis; Channel, misc.; Inhibitor; Membrane protein, integral; Mitochondrial Q07820 4170 1q21.2 human T68-p 31863755 AGASPPStLTPDSRR protein stabilization 27738316 1 0 1 -H3-3A H3F3A DNA-binding P84243 3020 1q42.12 human K79-m2 18545333 REIAQDFkTDLRFQS Histone molecular association, regulation L3MBTL iso4(INDUCES) 23583077 0 3 2 -Trpm7 ChaK1 Channel, cation; EC 2.7.11.1; KINASE; Kinase, protein; Membrane protein, integral; Membrane protein, multi-pass; Protein kinase, Ser/Thr (non-receptor); Protein kinase, atypical Q923J1 58800 2|2 F1 mouse S1403-p 2512922 PPTKFSVsTPSQPSC molecular association, regulation; intracellular localization 14-3-3 theta(INDUCES) 29866880 2 21 24 S1403 is a stronger interaction site -Piwil1 PIWIL1 Membrane protein, peripheral Q9JMB7 57749 5 G1.3|5 67.86 cM mouse R14-m2 9859901 ARARGRArGQETVQH GAGE molecular association, regulation; intracellular localization TDRKH(INDUCES); TDRD9(INDUCES); TDRD1(INDUCES); TDRD6(INDUCES); TDRD7(INDUCES) 19584108 1 1 0 -FSCN1 fascin Actin-binding; Cytoskeletal; Motility/polarity/chemotaxis Q16658 6624 7p22.1 human T403-p 15720201 GCRKVTGtLDANRSS Fascin protein conformation carcinogenesis, inhibited; cell growth, inhibited; cytoskeletal reorganization; cell motility, inhibited 35219877 1 9 0 -RARA RARA DNA-binding; Nuclear receptor; Oncoprotein; Transcription factor P10276 5914 17q21.2 human K399-sm 10902800 AERVITLkMEIPGSM Hormone_recep intracellular localization transcription, induced 19850744 1 0 0 -Keap1 KEAP1 Endoplasmic reticulum; Motility/polarity/chemotaxis; Transcription regulation; UBIQUITIN LIGASE; Ubiquitin conjugating system Q9Z2X8 50868 9|9 A3 mouse Y85-p 25123100 DVTLQVKyEDIPAAQ BTB protein degradation; ubiquitination; intracellular localization 22448038 1 0 0 required for the nuclear export of KEAP1, Cul3 and Rbx1 -MAVS MAVS Adaptor/scaffold; Membrane protein, integral Q7Z434 57506 20p13 human R52-m1 1881446400 TCTLSGNrDTLWHLF molecular association, regulation RIGI(DISRUPTS) 34171297 1 1 0 abolishes MAVS agregation -DAB2 DAB2 Adaptor/scaffold; Tumor suppressor P98082 1601 5p13.1 human S723-p 18008467 KPAPRQVsLPVTKST molecular association, regulation; intracellular localization ARHGAP27(DISRUPTS) 28876503; 33557943 2 11 0 -Huwe1 HUWE1 EC 6.3.2.-; EC 6.3.2.19; Ligase; UBIQUITIN LIGASE; Ubiquitin conjugating system; Ubiquitin ligase NP_001395856 501546 rat Y4351-p 13196101 SNTEYHKyQSNSIQI HECT molecular association, regulation transcription, inhibited 7478539 2 0 0 mutation of Y3007 attenuated HUWE1 inhibition of p53-mediated transcription -Stat3 STAT3 DNA-binding; Motility/polarity/chemotaxis; Nuclear receptor co-regulator; Transcription factor P42227 20848 11 D|11 63.82 cM mouse K679-ac 486388 YLYPDIPkEEAFGKY acetylation; phosphorylation transcription, inhibited SIRT1(INDUCES) 19295512 1 1 0 SIRT1 downregulates phosphorylation at STAT3-Y705 and transactivation, deacetylation of STAT3 -NIBAN2 FAM129B Cell adhesion Q96TA1 64855 9q34.11 human Y593-p 25299904 PIDWGEEySNSGGGG molecular association, regulation; phosphorylation carcinogenesis, induced; signaling pathway regulation HRas(INDUCES) 26721396 1 1 4 promotes the dissociation of p120RasGAP from H-Ras; regulates phosphorylation of Ser residues of Meg-3 -Cd5 CD5 Cell surface; Membrane protein, integral P13379 12507 19 A|19 7.16 cM mouse Y452-p 447774 ASHVDNEySQPPRNS molecular association, regulation PIK3R1(NOT_REPORTED) 9079809 6 10 292 -PIP5K1C PIP5K1C Carbohydrate Metabolism - inositol phosphate; EC 2.7.1.68; Kinase, lipid; Motility/polarity/chemotaxis O60331 23396 19p13.3 human K255-ub 125104501 MHLKFDLkGSTYKRR PIP5K protein degradation; ubiquitination 28581524 1 0 0 -TGFBR1 TGFBR1 EC 2.7.11.30; KINASE; Kinase, protein; Membrane protein, integral; Protein kinase, Ser/Thr (receptor); Protein kinase, TKL; Receptor, misc. P36897 7046 9q22.33 human T200-p 4325704 LPLLVQRtIARTIVL TGF_beta_GS molecular association, regulation; phosphorylation; enzymatic activity, induced cell differentiation, induced; signaling pathway regulation FKBP12(DISRUPTS) 23290522; 7774578 2 0 0 TGFBR I-SMAD pathway ; T200V mutation prevented ligand-induced phosphorylation at other residues -E2f8 E2F8 DNA-binding; Transcription factor Q58FA4 108961 7|7 B4 mouse S395-p 10994497 PSFTRHPsLIKLVKS molecular association, regulation cell cycle regulation; apoptosis, inhibited; transcription, induced 14-3-3 zeta(INDUCES) 29363506 1 4 7 -IRS2 IRS2 Adaptor/scaffold; Motility/polarity/chemotaxis Q9Y4H2 8660 13q34 human Y823-p 454963 CGGDSDQyVLMSSPV activity, induced 34731634 1 29 692 -AJUBA JUB Cell adhesion; Motility/polarity/chemotaxis; Transcription, coactivator/corepressor Q96IF1 84962 14q11.2 human S39-p 18011036 GPGKGRLsGLGGPRK autophagy, induced 34706234 1 4 0 induces mitophagy -FBXO4 FBXO4 Ligase; UBIQUITIN LIGASE; Ubiquitin conjugating system; Ubiquitin ligase Q9UKT5 26272 5p13.1 human S12-p 453026 EPRSGTNsPPPPFSD molecular association, regulation; ubiquitination; enzymatic activity, induced FBXO4(INDUCES); 14-3-3 epsilon(INDUCES) 18598945; 21242966 2 37 0 FBX4 dimerization ; promotes cyclin D1 degradation and inhibits oncogenic transformation -NFE2L2 NRF2 DNA-binding; Transcription factor Q16236 4780 2q31.2 human K443-ac 7106325 HRKTPFTkDKHSSRL molecular association, regulation transcription, induced DNA(INDUCES) 19273602 1 1 0 -CCDC106 CCDC106 Q9BWC9 29903 19q13.42 human S130-p 31084482 GGAGGEAsDPESAAS CCDC106 molecular association, regulation; intracellular localization carcinogenesis, induced; cell motility, induced; cell growth, induced; apoptosis, inhibited; signaling pathway regulation p53(INDUCES) 30885251 1 5 0 -NCKIPSD NCKIPSD Adaptor/scaffold; Motility/polarity/chemotaxis; Oncoprotein Q9NZQ3 51517 3p21.31 human T242-p 1868827200 PGSSCSPtPPPVPRR molecular association, regulation RAB5A(INDUCES); GAPVD1(INDUCES) 31358736 1 0 0 -ACE2 ACE2 EC 3.4.17.23; Membrane protein, integral; Protease Q9BYF1 59272 Xp22.2 human S776-p 1880091000 KKKNKARsGENPYAS protein stabilization 35894122 1 1 0 SARS-CoV-2 infection induces GLK overexpression and subsequent ACE2 stabilization -DCBLD2 DCBLD2 Cell adhesion; Membrane protein, integral Q96PD2 131566 3q12.1|3 human Y666-p 478858 GQEVYHAyAEPLPIT molecular association, regulation CRKL(INDUCES) 23770091 2 3 1 -ERBB4 HER4 EC 2.7.10.1; KINASE; Kinase, protein; Membrane protein, integral; Protein kinase, TK; Protein kinase, tyrosine (receptor) Q15303 2066 2q34 human Y1056-p 451500 GHSPPPAyTPMSGNQ activity, induced; molecular association, regulation cell growth, altered PIK3C2A(INDUCES); Arg(INDUCES); PIK3R3(INDUCES); PIK3R2(INDUCES); CBL(INDUCES); PIK3R1(INDUCES) 16729043; 16934755; 18721752; 8617750 3 1 1 critical for HER4 activity to inhibit colony formation -Mapt Tau ACETYLTRANSFERASE; Acetyltransferase; Cytoskeletal P19332 29477 10q32.1 rat S715-p 449082 PVVSGDTsPRHLSNV cytoskeletal reorganization 18245083 145 54 69 -RRAGA RRAGA G protein regulator, misc. Q7L523 10670 9p22.1 human K230-ub 22251391 RDVHRFEkISNIIKQ Gtr1_RagA molecular association, regulation; phosphorylation autophagy, induced; signaling pathway regulation NPRL3(INDUCES); Raptor(DISRUPTS); DEPDC5(INDUCES); NPRL2(INDUCES) 25936802 1 3 0 interaction with GATOR1 complex, regulates mTORC1 signaling, regulates p70S6K phosphorylation -BLNK BLNK Adaptor/scaffold Q8WV28 29760 10q24.1 human Y84-p 449841 EHSDSEMyVMPAEEN molecular association, regulation transcription, altered PLCG1(INDUCES); PLCG2(INDUCES); Btk(INDUCES); NCK2(INDUCES); VAV1(INDUCES) 12456653; 9697839 4 0 0 -Phlpp2 PHLPP2 EC 3.1.3.16; PHOSPHATASE; Protein phosphatase, Ser/Thr (non-receptor); Tumor suppressor Q8BXA7 244650 8|8 D3 mouse S1116-p 17546653 PRPERRCsLHPASSA protein degradation; molecular association, regulation KCTD17(INDUCES) 28859855 1 9 0 -Irs2 IRS2 Adaptor/scaffold; Motility/polarity/chemotaxis F1MAL5 29376 16q12.5 rat S724-p 3217368 GGGYKASsPAESSPE phosphorylation 36207218 9 15 4 inhibits phosphorylation of PI3K, AKT, and eNOS -Ncl NCL DNA-binding; Helicase; Nuclear receptor co-regulator; Nucleolus; RNA-binding P09405 17975 1 C5|1 43.94 cM mouse S34-p 466005 DSEDEEMsEDEDDSS molecular association, regulation carcinogenesis, induced; cell growth, induced; transcription, induced RNA(INDUCES) 37039106 3 42 9 -AURKA AurA EC 2.7.11.1; KINASE; Kinase, protein; Oncoprotein; Protein kinase, Other; Protein kinase, Ser/Thr (non-receptor) O14965 6790 20q13.2 human S51-p 457655 AQRVLCPsNSSQRIP protein stabilization cell cycle regulation; cell growth, induced 17229885; 17895985 3 3 0 dephosphorylation by PPP2CA leads to the protein degradation; transformation -Raf1 RAF1 EC 2.7.11.1; KINASE; Kinase, protein; Oncoprotein; Protein kinase, Ser/Thr (non-receptor); Protein kinase, TKL Q99N57 110157 6 E3|6 53.62 cM mouse S259-p 447741 SQRQRSTsTPNVHMV molecular association, regulation; intracellular localization; enzymatic activity, inhibited cell growth, altered 14-3-3 beta(INDUCES); HRas(DISRUPTS); MEK1(DISRUPTS) 11782426; 11997508; 20212043 58 32 142 -TFAM TFAM DNA-binding; Transcription regulation Q00059 7019 10q21.1 human S61-p 27530800 VSSYLRFsKEQLPIF HMG_box transcription, induced 35278431 2 2 0 -CD44 CD44 Cell adhesion; Membrane protein, integral; Motility/polarity/chemotaxis; Receptor, misc. P16070 960 11p13 human S697-p 465669 AVEDRKPsGLNGEAS cell motility, altered 16785995 1 31 25 critical for chemotaxis -Scnn1b ENaC-beta Channel, sodium; Membrane protein, integral; Membrane protein, multi-pass; Transporter, ion channel P37090 24767 1q36 rat S631-p 2228600 QPLDTMEsDSEVEAI activity, induced; intracellular localization 18308722 1 1 0 membrane expression of ENAC beta and gamma, and may translocate CK2 to the cell membrane.; channel activation -NR4A1 Nur77 Apoptosis; DNA-binding; Nuclear receptor P22736 3164 12q13.13 human S152-p 25692904 SFQPPQLsPWDGSFG protein stabilization 22789442 1 0 0 Pin1 increases stability by acting on CK2 phosphorylated S152 -TNFRSF1A TNF-R1 Membrane protein, integral; Receptor, cytokine P19438 7132 12p13.31 human Y360-p 464365 TDDPATLyAVVENVP Death transcription, induced 21724995 1 0 1 -H3-3A H3F3A DNA-binding P84243 3020 1q42.12 human K9-ac 18545308 RTKQTARkSTGGKAP Histone phosphorylation 16185088 1 6 55 detecting S10 phosphorylation with phospho-antibody was disrupted in dual modified peptides with K9ac and K9 monomethyl as was S28 with K27ac -Lcp2 SLP76 Adaptor/scaffold Q60787 16822 11|11 A4 mouse Y112-p 448218 WSSFEDDyESPNDDD molecular association, regulation; phosphorylation cell differentiation, altered; apoptosis, altered; cytoskeletal reorganization; cell adhesion, altered; transcription, induced; signaling pathway regulation; transcription, altered VAV1(INDUCES) 11313406; 12640123; 16456002; 18342008; 18663126; 22291096; 9047237 17 0 0 mutation of this site impairs thrombus formation; required for intergrin activation -Rarg RARG iso2 DNA-binding; Nuclear receptor P18911-2 19411 15 F3|15 57.4 cM mouse S360-p 62884000 YARRRRPsQPYMFPR Hormone_recep activity, induced 31740618 2 0 0 -Yap1 YAP1 Oncoprotein; Transcription, coactivator/corepressor P46938 22601 9|9 A1 mouse S94-p 452305 KSHSRQAsTDAGTAG intracellular localization transcription, inhibited; signaling pathway regulation 33046882; 34133792 23 63 341 -Cd4 CD4 Cell surface; Membrane protein, integral P06332 12504 6 F2|6 59.17 cM mouse S432-p 451188 QRQAARMsQIKRLLS Tcell_CD4_C intracellular localization 19050241 3 0 3 -Ccnt1 CCNT1 Cell cycle regulation; Transcription initiation complex Q9QWV9 12455 15|15 F1 mouse K404-ac 9263557 AEELAAQkRQLENME molecular association, regulation; enzymatic activity, induced transcription, induced BCDIN3(DISRUPTS); HEXIM1(DISRUPTS) 19387490 2 1 2 enhances CDK9/cyclin T1 transcriptional activity, disrupting HEXIM1 and BCDIN3 association -BRCA1 BRCA1 EC 6.3.2.-; Nuclear receptor co-regulator; Transcription, coactivator/corepressor; Tumor suppressor; UBIQUITIN LIGASE; Ubiquitin conjugating system; Ubiquitin ligase P38398 672 17q21.31 human S1542-p 450009 EEQQLEEsGPHDLTE molecular association, regulation ATM(INDUCES) 10550055 1 9 0 -Crem CREM DNA-binding; Transcription factor P27699 12916 18|18 A1 mouse S133-p 448412 EILSRRPsYRKILNE pKID activity, induced; activity, inhibited transcription, induced; transcription, altered 17526487; 7923380; 8114763; 8404858 6 2 40 -SNIP1 SNIP1 Inhibitor Q8TAD8 79753 1p34.3 human K108-sm 55438617 HHSTVKVkQEREDHP molecular association, regulation cell motility, induced; transcription, induced 27703003 1 1 0 SUMOylation decreases the inhibitory effect of SNIP1 on TGF-beta-induced formation of the Smad2/4 and Smad3/4 complexes -SP100 SP100 DNA-binding; Transcription, coactivator/corepressor P23497 6672 2q37.1 human K297-sm 2793911 SVRLVDIkKEKPFSN protein degradation; molecular association, regulation chromatin organization, altered HP1 alpha(INDUCES) 11313457; 23485562 6 4 0 -Ap2m1 AP2M1 Adaptor/scaffold; Vesicle P84092 116563 11q23 rat S45-p 2048345 HARQQVRsPVTNIAR Clat_adaptor_s molecular association, regulation signaling pathway regulation TRPV1(DISRUPTS) 31186372 1 6 0 -KLF1 KLF1 C2H2-type zinc finger protein; DNA-binding; Transcription factor Q13351 10661 19p13.13 human K288-ac 461016 CAHPGCGkSYTKSSH zf-C2H2 acetylation; molecular association, regulation chromatin organization, altered; transcription, induced DNA(INDUCES) 11259590; 18710946 3 0 0 induces H3 acetylation; acetylation increased ability to interact with SWI-SNF complex -BCAR3 BCAR3 Adaptor/scaffold; GEF; GEF, Ras; Motility/polarity/chemotaxis O75815 8412 1p22.1 human Y117-p 454975 LLDPTVEyVKFSKER protein degradation; molecular association, regulation; ubiquitination; phosphorylation cell motility, induced SOCS6(INDUCES) 34169835 1 10 115 induces Cas phosphorylation -PPP1R2 PPP1R2 Inhibitor; Motility/polarity/chemotaxis; Protein phosphatase, regulatory subunit P41236 5504 3q29 human S122-p 449053 RIQEQESsGEEDSDL IPP-2 intracellular localization 9405437 3 74 29 Phosphorylation is required for nuclear localization during S phase. -SMN1 SMN RNA processing; RNA-binding Q16637 6606 5q13.2 human S63-p 33586274 NGDICETsGKPKTTP SMN molecular association, regulation; protein conformation cell growth, induced SMN(INDUCES) 34161763 1 2 0 -Lrrk2 LRRK2 EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, Ser/Thr (non-receptor); Protein kinase, TKL Q5S006 66725 15|15 E3 mouse S910-p 4725893 LVKRKSNsISVGEVY molecular association, regulation; enzymatic activity, inhibited autophagy, induced 14-3-3 beta(INDUCES); 14-3-3 theta(INDUCES); 14-3-3 zeta(INDUCES); 14-3-3 epsilon(INDUCES); 14-3-3 eta(INDUCES) 20642453; 20659021; 37454104 22 17 0 -IL24 IL24 Motility/polarity/chemotaxis; Secreted; Secreted, signal peptide Q13007 11009 1q32.1 human S101-p 41122604 QEVLQNVsDAESCYL activity, induced; intracellular localization cell cycle regulation; carcinogenesis, inhibited; cell growth, inhibited; cell motility, inhibited; signaling pathway regulation 26009991 1 0 0 IL24 maturation and secretion; activates Caspase-9, PARP, and JNK; inhibits the AKT signaling pathway -MARK3 MARK3 iso3 EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, CAMK; Protein kinase, Ser/Thr (non-receptor) P27448-3 4140 14q32.32-q32.33 human T90-p 3597303 AIKIIDKtQLNPTSL Pkinase enzymatic activity, inhibited 15319445 1 0 0 -TP53 p53 Activator; DNA-binding; Motility/polarity/chemotaxis; Nuclear receptor co-regulator; Transcription factor; Tumor suppressor P04637 7157 17p13.1 human K291-ub 9381803 TEEENLRkKGEPHHE protein degradation cell cycle regulation; cell growth, induced; apoptosis, inhibited 19536131; 33568778 2 0 0 -Suds3 SDS3 Helicase Q8BR65 71954 5|5 F mouse S228-p 454398 RTLNKLKsPKRPASP Sds3 activity, induced; acetylation apoptosis, induced; transcription, altered; cell growth, altered 15489224; 22398430 2 4 3 induce HDAC1 activity -Twist1 TWIST1 Cell development/differentiation; DNA-binding; Inhibitor; Transcription regulation P26687 22160 12 A3|12 14.81 cM mouse Y107-p 10943328 GGGSPQSyEELQTQR molecular association, regulation G3BP-2(DISRUPTS) 25893917 2 2 0 matrix stiffness -HMGB1 HMGB1 DNA repair, damage; Nuclear receptor co-regulator P09429 3146 13q12.3 human S53-p 25604400 SERWKTMsAKEKGKF HMG_box_2 intracellular localization 22750245 1 3 0 -CAMKK2 CAMKK2 Autophagy; EC 2.7.11.17; KINASE; Kinase, protein; Protein kinase, Other; Protein kinase, Ser/Thr (non-receptor) Q96RR4 10645 12q24.31 human T85-p 31873289 GQEVPLDtSGSQARP phosphorylation; enzymatic activity, induced signaling pathway regulation 26395653; 32216002 2 2 0 autonomous activity in the presence of EGTA was lost in a CaMKK2 T85A mutant, molecular memory; induces phosphorylation of substrate AMPK, thus inducing CAMKK2 signaling -EGLN1 EGLN1 EC 1.14.11.29; Oxidoreductase Q9GZT9 54583 1q42.2 human T405-p 15409614 RAKVKYLtGEKGVRV molecular association, regulation; protein conformation HIF1A(INDUCES) 36902141 1 0 1 -VGLL1 VGLL1 Transcription, coactivator/corepressor Q99990 51442 Xq26.3 human S84-p 1870773106 PNQWRYSsPWTKPQP molecular association, regulation carcinogenesis, induced; cell growth, induced; transcription, induced TEAD4(INDUCES) 33069758 1 0 0 -ADGRE5 CD97 GPCR, family 2; Membrane protein, integral; Membrane protein, multi-pass; Receptor, GPCR P48960 976 19p13.12 human S833-p 3190861 RALRASEsGI_____ molecular association, regulation; intracellular localization cytoskeletal reorganization; signaling pathway regulation; cell adhesion, inhibited DLG1(DISRUPTS) 30134161 1 11 0 -Ripk3 RIPK3 EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, Ser/Thr (non-receptor); Protein kinase, TKL Q9QZL0 56532 14|14 C3 mouse S165-p 27928503 KLADFGLsTFQGGSQ Pkinase molecular association, regulation; enzymatic activity, inhibited; phosphorylation apoptosis, induced; signaling pathway regulation RIPK1(INDUCES); FADD(INDUCES); CASP8(INDUCES) 34029184 3 2 0 inhibits phosphorylation of RIPK3-S227, induces RIPK1/FADD/caspase-8 pathway -KEAP1 KEAP1 Endoplasmic reticulum; Motility/polarity/chemotaxis; Transcription regulation; UBIQUITIN LIGASE; Ubiquitin conjugating system Q14145 9817 19p13.2 human K108-ub 12344574 ASSSPVFkAMFTNGL BTB protein degradation 36163178 1 2 5 -CBL CBL Adaptor/scaffold; EC 6.3.2.-; EC 6.3.2.19; Ligase; Motility/polarity/chemotaxis; Oncoprotein; UBIQUITIN LIGASE; Ubiquitin conjugating system; Ubiquitin ligase P22681 867 11q23.3 human Y700-p 448529 EGEEDTEyMTPSSRP protein degradation; molecular association, regulation; enzymatic activity, induced cell growth, induced; cell motility, altered; signaling pathway regulation; cell growth, altered Src(INDUCES); CRKL(INDUCES); CRK(INDUCES); PIK3CA(INDUCES); VAV1(INDUCES) 11997497; 12604776; 12881521; 15922744; 21967979; 33512474; 9988765 16 19 493 The double mutant Y700/774F was used in this study; induces cytokine signaling; integrin-mediated platelet outside-in signaling leading to platelet spreading; Src induces Cbl phosphorylation inducing Cbl degredation and alters EGFR desensitization. -MAPRE1 EB1 Cytoskeletal; Motility/polarity/chemotaxis Q15691 22919 20q11.21 human T166-p 476323 APQRPIStQRTAAAP intracellular localization carcinogenesis, inhibited; cell growth, inhibited; apoptosis, induced; cytoskeletal reorganization; cell motility, inhibited 24930764 1 2 2 increased microtubule growth rate in T166A mutant; Increased sensitivity to microtubulr targeting agents -Gab2 GAB2 Adaptor/scaffold Q9Z1S8 14389 7|7 E1 mouse Y603-p 449788 KSTGSVDyLALDFQP molecular association, regulation cell differentiation, altered; cell growth, altered SHP-2(INDUCES) 11287610 6 8 55 -PLEKHG2 PLEKHG2 GEF; GEF, misc.; Tumor suppressor Q9H7P9 64857 19q13.2 human Y489-p 23133014 SEPVKDPyVMFPQNA molecular association, regulation Arg(INDUCES); Abl(INDUCES); PIK3R3(INDUCES); PIK3R1(INDUCES) 24378532 1 1 2 -FOXM1 FOXM1 DNA-binding; Transcription factor Q08050 2305 12p13.33 human K495-sm 31898507 PSPAPSFkEESSHSW protein degradation; ubiquitination; intracellular localization cell cycle regulation; cell growth, inhibited; transcription, inhibited 24362530 2 0 0 -KIT Kit EC 2.7.10.1; KINASE; Kinase, protein; Membrane protein, integral; Oncoprotein; Protein kinase, TK; Protein kinase, tyrosine (receptor) P10721 3815 4q12 human Y900-p 450042 EHAPAEMyDIMKTCW PK_Tyr_Ser-Thr protein stabilization; molecular association, regulation PIK3C2A(INDUCES); CRK(INDUCES) 12878163 1 0 2 -HES6 HES6 Transcription, coactivator/corepressor Q96HZ4 55502 2q37.3 human S183-p 455670 GPGDDLCsDLEEAPE cell cycle regulation 12972610 1 0 0 -JUN Jun Oncoprotein; Transcription factor P05412 3725 1p32.1 human S63-p 447686 KNSDLLTsPDVGLLK Jun activity, induced; acetylation; protein stabilization; molecular association, regulation; enzymatic activity, induced cell cycle regulation; carcinogenesis, induced; apoptosis, altered; carcinogenesis, inhibited; cell motility, induced; apoptosis, induced; transcription, induced; transcription, altered; cell growth, induced; transcription, inhibited; cell growth, altered TCF4(INDUCES); HDAC3(DISRUPTS); JNK1(DISRUPTS); MBD3(DISRUPTS); PIN1(INDUCES); NFkB-p65(INDUCES) DNA(INDUCES); DNA(DISRUPTS) 11313929; 11401472; 11432833; 11739718; 12040039; 12853483; 14617628; 1496019; 15378002; 18443042; 18794113; 19118012; 1922387; 20395206; 21697492; 23720779; 26745678; 26755651; 33822843; 34408980; 34764490; 34785213; 35000271; 35263587; 36253406; 36483740; 37020040; 37261387; 7737130; 7744008; 8072547; 8224842 133 43 4 -Foxo1 FOXO1A DNA-binding; Nuclear receptor co-regulator; Oncoprotein; Transcription factor Q9R1E0 56458 3 C|3 23.19 cM mouse S467-p 478371 KELLTSDsPPHNDIM FOXO_KIX_bdg molecular association, regulation; intracellular localization transcription, inhibited DUSP6(INDUCES) 22503562; 22848439 3 11 0 -ARRB2 ARRB2 Adaptor/scaffold P32121 409 17p13.2 human K295-sm 25350103 LALDGKLkHEDTNLA Arrestin_C molecular association, regulation; ubiquitination transcription, induced; signaling pathway regulation TRAF6(DISRUPTS) 25425640 2 0 0 enhances TRAF6 oligomerization, regulation of TRAF6 signaling -Pde3a PDE3A EC 3.1.4.17; Membrane protein, integral; Membrane protein, multi-pass; Nucleotide Metabolism - purine; Phosphodiesterase Q9Z0X4 54611 6|6 G2 mouse S291-p 471416 WKRRRRSsSVVAGEM enzymatic activity, induced 17124499 2 2 9 activated during oocytes maturation in mouse treated with hCG ; required for insulin-dependent Xenopus oocyte maturation -HES1 HES1 Cell development/differentiation; Motility/polarity/chemotaxis; Transcription factor Q14469 3280 3q29 human K109-ub 22245544 TDPSVLGkYRAGFSE Hairy_orange protein degradation cell differentiation, induced 29070679 1 2 0 -Mpc2 MPC2 Membrane protein, multi-pass; Mitochondrial Q9D023 70456 1|1 H2.2 mouse K26-ac 1195924 KVELLLPkKLRPLYN protein degradation; activity, inhibited 28154187 1 2 6 inhibits pyruvate transport activity -Ulk1 ULK1 Autophagy; EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, Other; Protein kinase, Ser/Thr (non-receptor) O70405 22241 5|5 F mouse S637-p 3176158 FDFPKTPsSQNLLTL cell cycle regulation; autophagy, induced; cell growth, induced; autophagy, altered 21205641; 32516310 4 35 41 -INTS11 INTS11 EC 3.1.27.-; RNA processing; Ribonuclease Q5TA45 54973 1p36.33 human K475-sm 1883375206 GLLPEAKkPRLLHGT molecular association, regulation; intracellular localization 36454007 1 0 0 regulates Integrator subcellular localization and interaction with integrator subunits -Braf BRAF iso1 EC 2.7.11.1; KINASE; Kinase, protein; Oncoprotein; Protein kinase, Ser/Thr (non-receptor); Protein kinase, TKL P28028-1 109880 6 B1|6 18.43 cM mouse S766-p 450242 PKIHRSAsEPSLNRA molecular association, regulation cell cycle regulation; cell growth, inhibited 14-3-3 beta(INDUCES); KSR(INDUCES) 24095280 8 59 25 -CDC37 CDC37 Chaperone Q16543 11140 19p13.2 human S97-p 1214257700 QLRKEERsWEQKLEE CDC37_N protein stabilization; molecular association, regulation HSP90A(INDUCES) 30068645 1 1 0 inhibits ubiquitination and degradation of AXL -GNAI1 G-alpha i1 G protein; G protein, heterotrimeric; G protein, heterotrimeric alpha G((i/o/t/z)) P63096 2770 7q21.11 human Y154-p 1871177702 QLNDSAAyYLNDLDR G-alpha enzymatic activity, induced carcinogenesis, induced; signaling pathway regulation 33139573 1 1 0 -Cry2 CRY2 DNA-binding; Lyase Q9R194 12953 2|2 E1 mouse K347-ub 27717314 RNPEALAkWAEGKTG FAD_binding_7 protein degradation; intracellular localization 23452856 1 1 0 -JUN Jun Oncoprotein; Transcription factor P05412 3725 1p32.1 human K268-ac 458866 RNRIAASkCRKRKLE bZIP_1 molecular association, regulation carcinogenesis, induced; transcription, induced; signaling pathway regulation DNA(INDUCES) 16214953; 27956703 3 0 0 AP-1 signaling pathway -Kcnd2 Kv4.2 Channel, potassium; Membrane protein, integral; Membrane protein, multi-pass Q63881 rat S447-p 4668101 SANAYMQsKRNGLLS intracellular localization; phosphorylation 18795890 1 0 1 increases phosphorylation at T602 and T607 by ERK -PPIP5K2 PPIP5K2 EC 2.7.4.21; EC 2.7.4.24; Kinase, lipid O43314 23262 5q21.1 human S1006-p 3175115 TGRRRRRsGEQITSS molecular association, regulation; intracellular localization carcinogenesis, inhibited; DNA repair, inhibited 14-3-3 gamma(INDUCES) 26084399; 34645979 2 40 46 -CDC6 CDC6 Cell cycle regulation Q99741 990 17q21.2 human S54-p 450914 RVKALPLsPRKRLGD protein stabilization; molecular association, regulation; intracellular localization cell cycle regulation CDH1(DISRUPTS) 10339564; 14749377; 16153703; 22179839; 23129444; 24216307; 9889196 10 15 0 -Runx2 AML3 DNA-binding; Transcription factor Q08775 12393 17 B3|17 21.33 cM mouse S380-p 10892804 DPRQAQSsPPWSYDQ protein stabilization; acetylation transcription, altered 20007706 10 2 0 stimulates AML3 acetylation -CD300LF IREM-1 Immunoglobulin superfamily; Membrane protein, integral; Receptor, misc. Q8TDQ1 146722 17q25.1 human S216-p 51635626 TLQLAGTsPQKATTK SIT signaling pathway regulation 32152116 1 1 0 -IRF7 IRF7 DNA-binding; Transcription factor Q92985 3665 11p15.5 human S472-p 1276103 TQREGVSsLDSSSLS transcription, inhibited 10893229 3 0 0 -MCL1 MCL1 Apoptosis; Channel, misc.; Inhibitor; Membrane protein, integral; Mitochondrial Q07820 4170 1q21.2 human T163-p 455375 TDGSLPStPPPAEEE protein degradation; protein stabilization; molecular association, regulation; ubiquitination cell cycle regulation; carcinogenesis, induced; carcinogenesis, inhibited; cell growth, induced; apoptosis, induced; apoptosis, inhibited; cell growth, altered BAK1(INDUCES); FBXW7(INDUCES); BIM(INDUCES); USP9X(INDUCES); NOXA(INDUCES); PIN1(INDUCES) 12223490; 18676833; 21368833; 21368834; 25915848; 26205817; 26219338; 27738316; 28301598; 33658484; 34758305; 36346691; 36455198 20 17 8 -Mdm4 MDM4 EC 6.3.2.-; Ligase; UBIQUITIN LIGASE; Ubiquitin conjugating system; Ubiquitin ligase O35618 17248 1 E4|1 57.75 cM mouse S402-p 474540 DLAHSSEsQEIISSA protein degradation; molecular association, regulation cell cycle regulation 14-3-3 gamma(INDUCES) 19808970; 24190973 13 2 0 -MAPK6 ERK3 EC 2.7.11.24; KINASE; Kinase, protein; Protein kinase, CMGC; Protein kinase, Ser/Thr (non-receptor) Q16659 5597 15q21.2 human S189-p 448267 YSHKGHLsEGLVTKW Pkinase molecular association, regulation; intracellular localization MAPKAPK5(INDUCES) 21317288 5 34 2 -IRS1 IRS1 Adaptor/scaffold; Motility/polarity/chemotaxis P35568 3667 2q36.3 human S639-p 447507 YMPMSPKsVSAPQQI intracellular localization 16914728 35 4 0 via cell fractionation experiments -ABL1 Abl EC 2.7.10.2; KINASE; Kinase, protein; Oncoprotein; Protein kinase, TK; Protein kinase, tyrosine (non-receptor) P00519 25 9q34.12 human Y312-p 4922741 CTREPPFyIITEFMT PK_Tyr_Ser-Thr enzymatic activity, induced 18775312 1 0 0 SH2 and catalytic domains of Fes and Abl interact with ligand, stimulating kinase activity. -CREB3L3 CREB3L3 Membrane protein, integral; Transcription factor Q68CJ9 84699 19p13.3 human S395-p 1880714004 ADTTREEsPGSPGAD exocytosis, induced 36649378 1 0 0 -FCHSD2 FCHSD2 Adaptor/scaffold O94868 9873 11q13.4 human S681-p 454693 SSLYFPRsPSANEKS intracellular localization endocytosis, induced; carcinogenesis, inhibited; cell growth, inhibited; cell motility, inhibited; signaling pathway regulation 30249660 1 15 106 EGFR/Ras/ERK1/2 pathway -MAZ MAZ C2H2-type zinc finger protein; RNA-binding; Transcription factor P56270 4150 16p11.2 human S460-p 465574 PTAVGSLsGAEGVPV transcription, induced Myc(NOT_REPORTED) 10448092 1 0 0 regulates DNA binding of MAZ to c-myc promoter element -DPF3 DPF3 iso2 C2H2-type zinc finger protein Q92784-2 8110 14q24.2 human S348-p 23251120 GRRSGRGsPTADKKG molecular association, regulation transcription, induced HEY1(INDUCES) 26582913 1 3 1 DPF3a initiates transcription of fetal genes and promotes pathological cardiac hypertrophy. -Pitpnb PITPNB Lipid-binding P53812 114561 12q16 rat S262-p 451299 ETMRKKGsVRGTSAA not reported 16540520; 16780419 5 17 22 S261 phosphorylation does not affect PITPNB localization to Golgi.; isoform containing S261 transfers sphingomyelin more efficiently; does not have an influence on the localization of PITPNB to Golgi membranes -ARHGEF7 ARHGEF7 GEF; GEF, Rac/Rho; Motility/polarity/chemotaxis Q14155 8874 13q34 human S703-p 455681 EEFASRKsTAALEED RhoGEF67_u2 activity, induced; molecular association, regulation cytoskeletal reorganization RAP1GDS1(DISRUPTS) 16954223 3 19 2 activates ARHGEF7's exchange activity on Rac1 -H2BC3 H2B DNA-binding P33778 3018 6p22.2 human K120-ac 3612295 EGTKAVTkYTSSK__ molecular association, regulation polybromo 1(INDUCES) 20368734 3 10 27 varying site specificity binding for each bromodomain 1-6 -MAP3K5 ASK1 EC 2.7.11.25; KINASE; Kinase, protein; Protein kinase, STE; Protein kinase, Ser/Thr (non-receptor) Q99683 4217 6q23.3 human T1326-p 27928509 VNGADEDtISRFLAE enzymatic activity, inhibited carcinogenesis, induced 23608533 1 1 0 -STK3 MST2 Autophagy; EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, STE; Protein kinase, Ser/Thr (non-receptor) Q13188 6788 8q22.2 human T180-p 448899 DTMAKRNtVIGTPFW Pkinase molecular association, regulation; protein processing; phosphorylation; enzymatic activity, induced cell cycle regulation; apoptosis, altered; carcinogenesis, inhibited; cell growth, inhibited; apoptosis, induced; signaling pathway regulation LATS1(INDUCES) 20086174; 20231902; 22389451; 24362629; 36622276; 37319316 15 0 5 -NR3C1 GR DNA-binding; Mitochondrial; Nuclear receptor; Transcription factor P04150 2908 5q31.3 human T635-p 1872513505 IINEQRMtLPCMYDQ Hormone_recep molecular association, regulation 14-3-3 zeta(INDUCES) 33744286 1 1 0 -Pdzrn3 PDZRN3 EC 6.3.2.-; Ligase; UBIQUITIN LIGASE; Ubiquitin conjugating system; Ubiquitin ligase Q69ZS0 55983 6|6 D3 mouse S962-p 23130749 TTDDDAMsEMKMGRY protein degradation cell motility, inhibited 34135125 1 2 3 -Mcm2 MCM2 DNA-binding; EC 3.6.4.12 P97310 17216 6|6 D1 mouse S27-p 452310 ISDPLTSsPGRSSRR cell cycle regulation 35508654 4 97 63 -PARK7 DJ-1 EC 3.4.-.-; Nuclear receptor co-regulator; Transcription regulation; Tumor suppressor Q99497 11315 1p36.23 human T125-p 1869992402 GFGSKVTtHPLAKDK DJ-1_PfpI protein degradation; protein conformation; enzymatic activity, induced 32858971 1 1 0 -SLC9A3R1 NHERF Adaptor/scaffold; Motility/polarity/chemotaxis E2RGF3 dog S348-p 455752 ERAHQKRsSKRAPQM EBP50_C molecular association, regulation; intracellular localization; enzymatic activity, inhibited Ezrin(DISRUPTS); ARHGEF7(DISRUPTS) 22301917 5 1 18 Rac1 activity inhibited -APEX1 APE1 DNA repair, damage; DNA-binding; Deoxyribonuclease; EC 4.2.99.18; Endoplasmic reticulum; Hydrolase; Lyase; Nuclear receptor co-regulator; Nucleolus; Transcription, coactivator/corepressor P27695 328 14q11.2 human K24-ub 6423508 LRTEPEAkKSKTAAK protein degradation; enzymatic activity, altered 19219073 1 1 0 -SEPTIN9 SEPT9 iso2 Cell cycle regulation; Cytoskeletal; Hydrolase Q9UHD8-2 10801 17q25.3 human T24-p 469506 EVETPNStPPRRVQT molecular association, regulation cell cycle regulation PIN1(INDUCES) 23990466 1 17 53 -CALCA CALCA Secreted; Secreted, signal peptide P01258 796 11p15.2 human S89-p 1871177714 SKRCGNLsTCMLGTY Calc_CGRP_IAPP protein conformation 33220304 0 1 0 regulation of peptide fibrillation -Myd88 MYD88 Adaptor/scaffold P22366 17874 9 F3|9 71.33 cM mouse Y257-p 474538 KRLIPIKyKAMKKDF TIR molecular association, regulation cell growth, altered PIK3R1(INDUCES) 17055754 4 0 0 required for Akt activation by CpG DNA -Braf BRAF iso1 EC 2.7.11.1; KINASE; Kinase, protein; Oncoprotein; Protein kinase, Ser/Thr (non-receptor); Protein kinase, TKL P28028-1 109880 6 B1|6 18.43 cM mouse T636-p 447807 IGDFGLAtVKSRWSG PK_Tyr_Ser-Thr activity, induced; phosphorylation carcinogenesis, induced; signaling pathway regulation 30659267 12 0 0 phosphorylation of MEK/ERK and its signaling -Trpc6 TRPC6 Channel, cation; Membrane protein, integral; Membrane protein, multi-pass Q99N78 89823 8q11 rat T69-p 470868 RLTHRRQtVLREKGR activity, inhibited 21799177 11 2 6 suppressed Agn-II induced calcium influx -PNPLA8 PNPLA8 EC 3.1.1.5; Membrane protein, integral; Motility/polarity/chemotaxis; Phospholipase Q9NP80 50640 7q31.1 human S515-p 18638842 KLGSDVFsQNVIVGT Patatin activity, induced; enzymatic activity, induced transcription, induced; signaling pathway regulation 23258543; 25492867 2 1 0 Increase PGE2 release and leads to conformational change in the enzyme; ATF6 activation -DDX39A DDX39 EC 3.6.4.13; Helicase; RNA splicing; RNA-binding O00148 10212 19p13.12 human K155-sm 1876998411 FGGLSIKkDEEVLKK DEAD molecular association, regulation RNA(DISRUPTS) 32393512 1 1 0 -CTNND1 CTNND1 Actin-binding; Adaptor/scaffold; Cell adhesion; G protein regulator, misc.; Motility/polarity/chemotaxis O60716 1500 11q12.1 human Y228-p 449648 YPGGSDNyGSLSRVT intracellular localization cell adhesion, induced 25386896; 26302406 8 45 1087 -MAFG MAFG Cell cycle regulation; DNA-binding O15525 4097 17q25.3 human S124-p 18011934 FARTVARsPVAPARG protein stabilization transcription, inhibited 25219500; 26787892 2 10 1 -UHRF1 UHRF1 DNA-binding; EC 6.3.2.-; EC 6.3.2.19; Ligase; Transcription factor; UBIQUITIN LIGASE; Ubiquitin conjugating system; Ubiquitin ligase Q96T88 29128 19p13.3 human K650-ac 1883407605 GKGKWKRkSAGGGPS cell cycle regulation; cell growth, induced 35951156 1 0 0 -IL6R IL6R Membrane protein, integral; Receptor, cytokine P08887 3570 1q21.3 human K401-ub 1881380904 LRALKEGkTSMHPPY receptor internalization, induced; protein degradation transcription, inhibited 34785732 1 0 0 In IL6R K401R and gp130 K849R mutants, IL-6-induced transcription of downstream genes compared to wild-type receptors. -Pi4k2a PI4K2A EC 2.7.1.67; Kinase, lipid; Motility/polarity/chemotaxis Q2TBE6 84095 19 C3|19 35.74 cM mouse S51-p 468435 SGPSPPCsPGHDRER phosphorylation 25083612 2 68 7 -SMAD1 SMAD1 DNA-binding; Transcription factor Q15797 4086 4q31.21 human K269-ub 1051004 AVAYEEPkHWCSIVY MH2 protein degradation 17963781 1 1 0 -SNAP25 SNAP-25 Vesicle P60880 6616 20p12.2 human S28-p 23939100 LADESLEsTRRMLQL exocytosis, induced 22311984 2 2 0 -ASAP3 DDEFL1 GAP; GAP, ARF; Motility/polarity/chemotaxis Q8TDY4 55616 1p36.12 human Y733-p 462087 LDISNKTyETVASLG molecular association, regulation endocytosis, induced; cell motility, inhibited GRB2(INDUCES) 22027826 1 4 10 promotes recycling of ITGB1, inhibits cell spreading -ATR ATR EC 2.7.11.1; KINASE; Kinase, protein; Membrane protein, integral; Protein kinase, Ser/Thr (non-receptor); Protein kinase, atypical Q13535 545 3q23 human S1333-p 34425600 ETVEPIIsQLVTVLL enzymatic activity, induced cell cycle regulation 24901225 1 0 0 S1333 A or D mutant, no noticeable checkpoint or replication defects -BCL3 Bcl-3 Apoptosis; Nuclear receptor co-regulator; Oncoprotein; Transcription regulation P20749 602 19q13.32 human S41-p 27444668 KRPLRAPsPEPAAPR protein stabilization; ubiquitination; intracellular localization transcription, induced 28689659 1 13 0 nuclear localization -PSME3 PSME3 Nuclear receptor co-regulator; Protease; Proteasome complex P61289 10197 17q21.31 human K12-sm 25344503 LKVDQEVkLKVDSFR PA28_alpha protein stabilization; intracellular localization; enzymatic activity, induced 21445096 1 0 0 -RPRM RPRM Membrane protein, integral Q9NS64 56475 2q23.3 human S98-p 15722493 LVKDRRPsKEVEAVV protein degradation; molecular association, regulation; intracellular localization IPO11(DISRUPTS) 36185355 1 5 0 -Yap1 YAP1 Oncoprotein; Transcription, coactivator/corepressor P46938 22601 9|9 A1 mouse S113-p 485035 QHVRAHSsPASLQLG activity, induced cell differentiation, induced; transcription, induced 36640330 8 12 77 -TCEAL1 SIIR iso2 Transcription initiation complex AAA60149 9338 Xq22.2 human S36-p 451217 PKSSPPRsSLRRSSP BEX transcription, altered 7592688 1 0 0 S36A/S37A mutation resulted in a substantial loss of LTR repression function suggesting that RSV LTR repression may be regulated by S36 and/or S37 phosphorylation. -TBC1D4 AS160 GAP; GAP, Rab O60343 9882 13q22.2 human S588-p 455920 RMRGRLGsVDSFERS molecular association, regulation endocytosis, induced; signaling pathway regulation 14-3-3 epsilon(INDUCES) 20410134; 26465605; 35810470 21 68 253 regulates insulin signaling; albumin endocytosis; multiple sites (6P) mutant -PRKN PARK2 EC 6.3.2.-; EC 6.3.2.19; Ligase; Translation; Translation regulation; UBIQUITIN LIGASE; Ubiquitin conjugating system; Ubiquitin ligase O60260 5071 6q26 human S131-p 454421 HTDSRKDsPPAGSPA intracellular localization; enzymatic activity, inhibited apoptosis, induced 17327227; 34990728 5 3 0 -STK11 LKB1 Autophagy; EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, CAMK; Protein kinase, Ser/Thr (non-receptor); Tumor suppressor Q15831 6794 19p13.3 human K48-ac 3173806 KRAKLIGkYLMGDLL molecular association, regulation; intracellular localization; enzymatic activity, inhibited; phosphorylation STRAD(DISRUPTS) 18687677 2 1 0 reduces LKB1 phosphorylation at Ser-428 and Thr-336 -MDM2 MDM2 EC 6.3.2.-; EC 6.3.2.19; Inhibitor; Ligase; NEDDYLATION LIGASE; Neddylation Ligase; Nucleolus; Oncoprotein; UBIQUITIN LIGASE; Ubiquitin conjugating system; Ubiquitin ligase Q00987 4193 12q15 human S118-p 15714603 NQQESSDsGTSVSEN protein degradation; molecular association, regulation; ubiquitination FBW1B(INDUCES) 20708156 2 0 0 -Insr INSR EC 2.7.10.1; KINASE; Kinase, protein; Membrane protein, integral; Protein kinase, TK; Protein kinase, tyrosine (receptor) P15208 16337 8 A1.1|8 1.82 cM mouse Y989-p 447685 YASSNPEyLSASDVF molecular association, regulation cell differentiation, induced IRS2(INDUCES); IRS1(INDUCES) 34694913; 35074429 25 0 0 -Tssk4 TSSK4 EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, CAMK; Protein kinase, Ser/Thr (non-receptor) Q9D411 71099 14|14 C3 mouse T197-p 27138201 SLSHLSQtYCGSFAY Pkinase enzymatic activity, induced 23054012 1 0 0 -Cdk16 CDK16 Cell cycle regulation; EC 2.7.11.22; KINASE; Kinase, protein; Motility/polarity/chemotaxis; Protein kinase, CMGC; Protein kinase, Ser/Thr (non-receptor) Q04735 18555 X A1.3|X 16.18 cM mouse S95-p 453454 TSSDEVQsPVRVRMR cell differentiation, induced 21335063 2 22 2 dendritic development -MAPKAPK5 MAPKAPK5 EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, CAMK; Protein kinase, Ser/Thr (non-receptor); Tumor suppressor Q8IW41 8550 12q24.12-q24.13 human S354-p 27452609 VSLKPLHsVNNPILR enzymatic activity, induced carcinogenesis, induced; cell motility, induced 35064619 1 10 1 -Dtna DTNA Motility/polarity/chemotaxis Q9D2N4 13527 18 A2|18 12.08 cM mouse Y730-p 1869344403 NELQLEEyLKQKLQD protein stabilization; molecular association, regulation KAP(INDUCES) 32532815 1 0 0 -Jak2 JAK2 EC 2.7.10.2; KINASE; Kinase, protein; Oncoprotein; Protein kinase, TK; Protein kinase, tyrosine (non-receptor) Q62120 16452 19 C1|19 23.73 cM mouse Y1007-p 448407 VLPQDKEyYKVKEPG PK_Tyr_Ser-Thr protein degradation; ubiquitination; enzymatic activity, induced cell growth, induced; signaling pathway regulation SOCS1(INDUCES) 11971965; 16705159; 16705160; 18160720; 20304997; 21685897; 24526685; 24614172; 30573679; 36356831; 9111318 80 5 15 cytokine signaling pathway -Zc3hav1 ZAP RNA-binding; Transferase Q8K3Y6 252832 4q22 rat S266-p 4776621 EFLSPVVsPLGSGPP activity, induced 22514281 1 8 0 -MRE11 MRE11A Cell cycle regulation; DNA repair, damage; DNA-binding; Deoxyribonuclease P49959 4361 11q21 human S561-p 23127159 MANDSDDsISAATNK protein stabilization; molecular association, regulation PIH1D1(INDUCES) 28436950 1 0 2 -CCNF CCNF Cell cycle regulation P41002 899 16p13.3 human T31-p 234613504 RRRPRNLtILSLPED protein stabilization cell cycle regulation 28954236 1 1 0 cell-cycle progression -NTRK3 TrkC EC 2.7.10.1; KINASE; Kinase, protein; Membrane protein, integral; Protein kinase, TK; Protein kinase, tyrosine (receptor) Q16288 4916 15q25.3 human Y710-p 464878 DVYSTDYyRLFNPSG PK_Tyr_Ser-Thr carcinogenesis, induced; signaling pathway regulation 10702799 1 0 10 -Map2 MAP2 iso3 Cytoskeletal; Motility/polarity/chemotaxis P15146-3 25595 9q32 rat K328-ac 62495518 DNIKYQPkGGQVQIV Tubulin-binding cytoskeletal reorganization 28002468 1 1 0 -ANPEP CD13 EC 3.4.11.2; Membrane protein, integral; Other Amino Acids Metabolism - glutathione; Protease; Receptor, misc. P15144 290 15q26.1 human T63-p 1870824601 TTNPASAtTLDQSKA molecular association, regulation 14-3-3 sigma(INDUCES) 33109610 1 0 0 -Rab8a RAB8A G protein; G protein, monomeric; G protein, monomeric, Rab; Motility/polarity/chemotaxis; Oncoprotein P55258 17274 8 B3.3|8 34.84 cM mouse T72-p 4709152 AGQERFRtITTAYYR Ras autophagy, inhibited 37454104 13 5 6 -Pard6a PARD6A Adaptor/scaffold; Cell adhesion; Motility/polarity/chemotaxis Q9Z101 56513 8|8 D3 mouse S345-p 15714600 RGDVSGFsL______ cell growth, altered 20603020 2 9 0 -NR1H4 NR1H4 iso2 DNA-binding; Nuclear receptor Q96RI1-2 9971 12q23.1 human K275-sm 31089517 EITNKILkEEFSAEE Hormone_recep molecular association, regulation transcription, inhibited DNA(DISRUPTS) 23546875 1 0 0 -TJP2 ZO2 Adaptor/scaffold; Motility/polarity/chemotaxis Q9UDY2 9414 9q21.11 human K759-ub 1883981502 PDWFQTAkTEPKDAG protein stabilization; molecular association, regulation occludin(INDUCES); ZO1(INDUCES) 36291162 1 0 0 stability of hZO-2 is regulated by K48 polyubiquitin and K759, K997 ubiquitylation and K730 SUMOylation, mutations in ZO2 ubiquitylation and ylation sites disrupt the interaction with occludin and ZO1as well as tight junction (TJ) barrier function -SPI1 PU.1 DNA-binding; Oncoprotein; Transcription factor P17947 6688 11p11.2 human S140-p 451055 EEEGERQsPPLEVSD protein degradation; molecular association, regulation; ubiquitination cell differentiation, inhibited FBXW7(INDUCES) 33188146 2 2 0 -MYB Myb DNA-binding; Oncoprotein; Transcription factor P10242 4602 6q23.3 human K527-sm 486352 PPLLKKIkQEVESPT Cmyb_C sumoylation; intracellular localization transcription, inhibited 12631292 4 1 0 -KCNQ1 Kv7.1 Channel, potassium; Membrane protein, integral; Membrane protein, multi-pass P51787 3784 11p15.5-p15.4 human S95-p 4712797 DPRVSIYsTRRPVLA activity, inhibited 29452158 1 2 3 mediate the inhibition of Ang II on the current -Vim Vimentin Cytoskeletal; Motility/polarity/chemotaxis P20152 22352 2 A1|2 10.04 cM mouse S47-p 455455 LGSALRPsTSRSLYS Filament_head cytoskeletal reorganization 12458200 3 18 10 -Pa2g4 Ebp1 Nuclear receptor co-regulator; Nucleolus; Transcription, coactivator/corepressor Q6AYD3 288778 7q11 rat S360-p 478276 ELKALLQsSASRKTQ molecular association, regulation; intracellular localization cell growth, altered Rb(DISRUPTS); Akt1(INDUCES) 16642037; 21145366 5 2 1 -Cit CRIK EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, AGC; Protein kinase, Ser/Thr (non-receptor) P49025 12704 5|5 F mouse Y1246-p 57761910 LENIQVLySHEKVKM molecular association, regulation cell cycle regulation RHOA(INDUCES) 27551053 1 1 0 prevents the completion of cytokinesis -TTK TTK Cancer Testis Antigen (CTA); EC 2.7.12.1; KINASE; Kinase, protein; Protein kinase, Other; Protein kinase, dual-specificity (non-receptor) P33981 7272 6q14.1 human S363-p 1737601 LKNKTESsLLAKLEE intracellular localization; enzymatic activity, induced cell cycle regulation 25265012; 26119734 4 4 0 regulates spindle assembly checkpoint and recruitment of SAC proteins; autophosphorylation of this site is required for release TTK from kinetochore; causes decreased kinetochore localization of BubR1 and Mad2. -ITGA4 ITGA4 Cell adhesion; Membrane protein, integral; Motility/polarity/chemotaxis; Receptor, misc. P13612 3676 2q31.3 human S1021-p 469620 QEENRRDsWSYINSK activity, induced; molecular association, regulation; phosphorylation carcinogenesis, induced; cell motility, induced; cell growth, inhibited; cell motility, altered; cytoskeletal reorganization PXN(DISRUPTS); PXN(INDUCES); syndecan-1(INDUCES); PXN iso2(DISRUPTS) 11533025; 12837751; 17603879; 18583710; 23979717; 31562188 8 33 111 -Stmn2 STMN2 Cytoskeletal P21818 84510 2q23 rat S97-p 455607 AAEGRRKsQEAQVLK Stathmin molecular association, regulation; activity, inhibited cytoskeletal reorganization TUBA1A(DISRUPTS); TUBB(DISRUPTS) 15825189; 9525956 5 3 1 -SVIL supervillin Actin-binding; Contractile; Motility/polarity/chemotaxis; Nuclear receptor co-regulator O95425 6840 10p11.23 human S238-p 468886 SFSGRDSsFTEVPRS molecular association, regulation; intracellular localization; phosphorylation cell cycle regulation PRC1(INDUCES) 23750008 1 29 1 inhibits aberrant furrowing, activates myosin II ; plays a role in cytokinesis -Ttc5 TTC5 Adaptor/scaffold Q99LG4 219022 14|14 C1 mouse S203-p 12559514 TGQNPKIsQQALSAY intracellular localization apoptosis, induced p300(INDUCES) 15448695 2 0 0 apoptosis in response to DNA damage -Gdi1 GDI1 G protein regulator, misc.; Motility/polarity/chemotaxis P50398 25183 Xq37 rat S213-p 12607403 INRIKLYsESLARYG GDI molecular association, regulation Rab4(INDUCES) 20051515 1 0 0 facilitates the membrane trafficking of AMPARs -PRMT5 PRMT5 Cell cycle regulation; EC 2.1.1.125; METHYLTRANSFERASE; Methyltransferase; Methyltransferase, protein arginine; RNA processing O14744 10419 14q11.2 human T139-p 1267669102 TNLARVLtNHIHTGH PRMT5_TIM enzymatic activity, induced 30289978 1 0 0 -RALGAPA2 RALGAPA2 GAP; GAP, Ras Q2PPJ7 57186 20p11.23 human S486-p 485552 SSWGRTYsFTSAMSR carcinogenesis, induced; signaling pathway regulation 22580611 2 20 39 cell invasion induced -NFKBIA IkB-alpha DNA-binding; Inhibitor P25963 4792 14q13.2 human Y42-p 448737 DSMKDEEyEQMVKEL activity, induced; protein degradation; molecular association, regulation apoptosis, inhibited; transcription, induced; transcription, altered NFkB-p65(DISRUPTS) 10754328; 11266466; 12432072; 12909638; 17533369; 8797825 15 1 28 -Ctnnb1 CTNNB1 Actin-binding; Cell adhesion; Motility/polarity/chemotaxis; Nuclear receptor co-regulator; Oncoprotein; Transcription factor Q02248 12387 9 F4|9 72.19 cM mouse S605-p 3545003 LFVQLLYsPIENIQR Arm intracellular localization 18423204 3 0 0 -NPAT NPAT Cell cycle regulation; Transcription regulation Q14207 4863 11q22.3 human S775-p 2286404 LPTIILSsPTKSPTK NPAT_C transcription, induced 10995387 1 2 0 multiple sites deletion mutant -PLA2G4A PLA2G4A EC 3.1.1.4; EC 3.1.1.5; Lipid Metabolism - alpha-linolenic acid; Lipid Metabolism - arachidonic acid; Lipid Metabolism - ether lipid; Lipid Metabolism - glycerophospholipid; Lipid Metabolism - linoleic acid; Phospholipase P47712 5321 1q31.1 human S228-p 450089 ATYVAGLsGSTWYMS PLA2_B activity, induced; enzymatic activity, induced 15539760; 18280113 4 0 0 S228 induced full activity, S505 partially -APC APC Motility/polarity/chemotaxis; Tumor suppressor P25054 324 5q22.2 human S1505-p 452096 DGFSCSSsLSALSLD APC_r molecular association, regulation; phosphorylation CTNNB1(INDUCES) 12628243; 17910481 2 0 0 phosphorylation by CK1 primes for S1501 phosphorylation by GSK3; based on acidic phospho-mimetic mutant -Ajuba JUB Cell adhesion; Motility/polarity/chemotaxis; Transcription, coactivator/corepressor Q91XC0 16475 14|14 C2 mouse T172-p 22499900 SRPCSNRtSGISMGY molecular association, regulation RAC1(INDUCES) 22105346 1 1 0 necessary for Rac activation by junctions -IRF7 IRF7 DNA-binding; Transcription factor Q92985 3665 11p15.5 human K452-ub 4666609 EKSLVLVkLEPWLCR IRF-3 transcription, induced 18710948 1 1 0 -Bcl2l11 BIM Apoptosis O88498 64547 3q36 rat K108-ub 25087002 PAPMSCDkSTQTPSP protein degradation 21378313 2 0 0 BIM was still degraded in the absence of these lysines defining a novel ubiquitin-independent pathway. -PTEN PTEN Carbohydrate Metabolism - inositol phosphate; EC 3.1.3.16; EC 3.1.3.48; EC 3.1.3.67; Motility/polarity/chemotaxis; Nuclear receptor co-regulator; PHOSPHATASE; Phosphatase, lipid; Tumor suppressor P60484 5728 10q23.31 human K60-ub 1881390901 VVRFLDSkHKNHYKI protein degradation; phosphorylation 34785642 1 0 0 AKT S473 increased ; regulates the HCC cell chemoresistance (chemoresistant) -Stxbp1 STXBP1 Vesicle P61765 25558 3p11 rat S313-p 448744 SLKDFSSsKRMNTGE Sec1 molecular association, regulation; intracellular localization exocytosis, altered STX1A(DISRUPTS) 15489225; 16997485; 29946239 7 0 0 regulates protein secretion by increasing vesicle pools replenishment after stimulation -PIP4K2C PIP4K2C Carbohydrate Metabolism - inositol phosphate; EC 2.7.1.149; Endoplasmic reticulum; Kinase, lipid; Motility/polarity/chemotaxis Q8TBX8 79837 12q13.3 human S328-p 34431500 LVGSYGTsPEGIGGY PIP5K intracellular localization; phosphorylation cell growth, inhibited; signaling pathway regulation 25372051 1 1 0 inhibits expression of phosphorylated p70S6K and S6, inhibits mTORC1 signaling, regulates cell size -FNIP1 FNIP1 Q8TF40 96459 5q31.1 human K1119-ub 1871197700 QELYFKSkMLSEYLR FNIP_C protein degradation; ubiquitination 30699359 1 0 0 -UBTF UBF DNA-binding; Nucleolus; Transcription factor P17480 7343 17q21.31 human S389-p 450170 INKKQATsPASKKPA transcription, induced 24798431 4 3 1 rDNA transcription -CASP1 CASP1 Apoptosis; EC 3.4.22.36; Protease P29466 834 11q22.3 human S376-p 469562 IFRKVRFsFEQPDGR Peptidase_C14 enzymatic activity, induced 15561713 1 0 0 -BUB1B BUB1B EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, Other; Protein kinase, Ser/Thr (non-receptor); Tumor suppressor O60566 701 15q15.1 human S884-p 20727431 EIVHGDLsPRCLILR enzymatic activity, inhibited cell cycle regulation 22698286 0 3 0 -PIK3C3 PIK3C3 Autophagy; Carbohydrate Metabolism - inositol phosphate; EC 2.7.1.137; Kinase, lipid; Motility/polarity/chemotaxis Q8NEB9 5289 18q12.3 human K29-ac 280006402 KIGSLEGkREQKSYK molecular association, regulation; enzymatic activity, inhibited autophagy, inhibited beclin 1(DISRUPTS) 28844862 1 1 0 nutrient starvation-induced autophagy -Cnbp ZNF9 DNA-binding; RNA-binding; Transcription factor P53996 12785 6|6 D1 mouse T173-p 471955 GHLARECtIEATA__ zf-CCHC molecular association, regulation; protein stabilization; intracellular localization cell growth, induced; transcription, induced; translation, induced SUFU(INDUCES) DNA(INDUCES) 26460945; 34168080 2 5 9 regulates Type I IFN promoter activity; translation of ornithine decarboxylase (ODC) -ESRRA ERR1 DNA-binding; Nuclear receptor; Transcription regulation P11474 2101 11q13.1 human K160-ac 15211512 RVRGGRQkYKRRPEV molecular association, regulation transcription, inhibited DNA(DISRUPTS) 20484414 1 0 0 -Ptk2b Pyk2 EC 2.7.10.2; KINASE; Kinase, protein; Nuclear receptor co-regulator; Protein kinase, TK; Protein kinase, tyrosine (non-receptor) Q9QVP9 19229 14 D1|14 34.36 cM mouse Y402-p 447955 CSIESDIyAEIPDET molecular association, regulation; phosphorylation; enzymatic activity, induced carcinogenesis, induced; apoptosis, induced; cell adhesion, induced; transcription, altered; neural plasticity; cell growth, induced; cytoskeletal reorganization; cell adhesion, altered DYN1(INDUCES); Src(INDUCES); Src iso1(INDUCES) 11149930; 12514172; 14739300; 16901726; 17581824; 19380485; 34529077; 35536885; 36038818 86 2 22 -OSBP2 OSBP2 Q969R2 23762 22q12.2 human S763-p 31727226 CSKVMHSsPSSPSSD Oxysterol_BP molecular association, regulation; protein conformation signaling pathway regulation Vimentin(INDUCES) 30925160 1 2 0 -Bcl2l11 BIM Apoptosis O54918 12125 2|2 F1 mouse Y92-p 56650528 LSRSSSGyFSFDTDR protein stabilization apoptosis, inhibited 29391601 1 1 0 -GLDC GLDC Amino Acid Metabolism - glycine, serine and threonine; EC 1.4.4.2; Oxidoreductase P23378 2731 9p24.1 human K514-ac 1186987 GIPGSVFkRTSPFLT protein degradation; enzymatic activity, inhibited carcinogenesis, inhibited; cell growth, inhibited 34244482 1 3 24 inhibits glycine catabolism and pyrimidine synthesis, suppresses tumorigenesis -Gabrb1 GABRB1 Channel, chloride; Channel, ligand-gated; Membrane protein, integral; Membrane protein, multi-pass; Transporter; Transporter, ion channel P50571 14400 5 C3.2|5 38.18 cM mouse S409-p 451812 IQYRKPLsSREGFGR Neur_chan_memb activity, induced; receptor desensitization, altered 10195104; 1323140 4 0 0 reduces rate of receptor internalization -PRKAA2 AMPKA2 Autophagy; EC 2.7.11.1; EC 2.7.11.27; EC 2.7.11.31; KINASE; Kinase, protein; Protein kinase, CAMK; Protein kinase, Ser/Thr (non-receptor) P54646 5563 1p32.2 human T172-p 448026 SDGEFLRtSCGSPNY Pkinase activity, induced; protein degradation; intracellular localization; phosphorylation; enzymatic activity, induced cell cycle regulation; carcinogenesis, induced; carcinogenesis, altered; carcinogenesis, inhibited; apoptosis, induced; cell growth, inhibited; transcription, altered; signaling pathway regulation; autophagy, induced; apoptosis, inhibited; cytoskeletal reorganization; transcription, inhibited 12391032; 15465812; 22304913; 22456184; 22561688; 23612973; 23716691; 23863464; 23982736; 32102879; 32209483; 32209654; 33755959; 33760042; 33898950; 34064003; 34193159; 34247189; 34421352; 34482636; 34604061; 34673141; 34787456; 34820368; 34921013; 34998825; 35035775; 35061665; 35290799; 35508122; 35522655; 35582406; 35761398; 35780182; 35975969; 35977966; 36008391; 36079767; 36139911; 36243112; 36387221; 36481655; 36611139; 36690274 220 13 33 -NLRP3 NLRP3 Inhibitor Q96P20 114548 1q44 human K496-ub 10998766 LRNHGLQkADVSAFL NOD2_WH protein degradation 32929041 2 1 1 -LEF1 LEF-1 DNA-binding; Transcription factor Q9UJU2 51176 4q25 human S42-p 471384 EKIFAEIsHPEEEGD CTNNB1_binding molecular association, regulation transcription, induced CTNNB1(INDUCES) 17113388 1 3 4 -MCM2 MCM2 DNA-binding; EC 3.6.4.12 P49736 4171 3q21.3 human S108-p 456310 DVEELTAsQREAAER MCM2_N molecular association, regulation; phosphorylation cell cycle regulation; carcinogenesis, induced; cell growth, induced; chromatin organization, altered FANCD2(INDUCES); FANCM(INDUCES); SIRT1(INDUCES) DNA(INDUCES) 16446360; 23993743; 31067464; 31776133; 35524559; 36082941 18 29 80 -TRPC6 TRPC6 Channel, cation; Membrane protein, integral; Membrane protein, multi-pass Q9Y210 7225 11q22.1 human S282-p 21358400 NAYKGLAsPAYLSLS TRP_2 phosphorylation signaling pathway regulation 23645677 2 0 0 increased ERK1 phosphorylation -DDR1 DDR1 EC 2.7.10.1; KINASE; Kinase, protein; Membrane protein, integral; Protein kinase, TK; Protein kinase, tyrosine (receptor) Q08345 780 6p21.33 human Y520-p 1026167 YRLLLATyARPPRGP activity, induced 24509848 1 9 86 phosphorylated in the N211QDDR1 mutant -Nr3c1 GR DNA-binding; Mitochondrial; Nuclear receptor; Transcription factor P06537 14815 18 B3|18 21.09 cM mouse S221-p 447967 DLEFSAGsPGKETNE GCR transcription, induced 21994940 20 7 0 -SUV39H1 SUV39H1 Amino Acid Metabolism - lysine degradation; EC 2.1.1.43; METHYLTRANSFERASE; Methyltransferase; Methyltransferase, protein lysine O43463 6839 Xp11.23 human K87-ub 63128901 LKCVRILkQFHKDLE Chromo protein degradation 28059589 1 2 0 -Cdh1 CDH1 Cell adhesion; Membrane protein, integral; Motility/polarity/chemotaxis; UBIQUITIN LIGASE; Ubiquitin ligase P09803 12550 8 D3|8 53.18 cM mouse S842-p 15754600 FDYEGSGsEAASLSS CADH_Y-type_LIR molecular association, regulation CTNNB1(INDUCES) 11348595 5 1 0 -Mef2d MEF2D DNA-binding; Transcription factor O89038 81518 2q34 rat T145-p 10359101 PNFAMPVtVPVSNQS HJURP_C activity, inhibited apoptosis, altered; transcription, inhibited 19801631 1 0 0 -Polb POLB DNA repair, damage; DNA replication; EC 2.7.7.7; Lyase; Transferase P06766 29240 16q12.5 rat S44-p 41521700 NAYRKAAsVIAKYPH HHH_8 enzymatic activity, inhibited 2040602 4 1 0 -MAP4 MAP4 Cytoskeletal; Motility/polarity/chemotaxis P27816 4134 3p21.31 human K1070-ac 62495528 FKEKAQAkVGSLDNV Tubulin-binding cytoskeletal reorganization 28002468 1 1 0 -WWTR1 TAZ Oncoprotein; Transcription, coactivator/corepressor Q9GZV5 25937 3q25.1 human T175-p 41594203 LHPAVSStPVPQRSM protein degradation 26183396 1 0 0 -GIT1 GIT1 GAP; GAP, ARF; Motility/polarity/chemotaxis Q9Y2X7 28964 17q11.2 human Y545-p 448965 ELEDDAIySVHVPAG molecular association, regulation cell motility, induced PXN(DISRUPTS); Hic-5(DISRUPTS) 25742295 4 39 737 phosphorylation-dephosphorylation required for coordinated cell movement, Y545-p was essential for Git1-mediated protrusion activity. -Kcnj8 KCNJ8 Channel, potassium; Membrane protein, integral; Membrane protein, multi-pass Q63664 25472 4q44 rat S397-p 471151 NSMRRSNsIRRNNSS activity, inhibited 18048350 1 2 0 -ULK1 ULK1 Autophagy; EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, Other; Protein kinase, Ser/Thr (non-receptor) O75385 8408 12q24.33 human S533-p 31868990 AEMRGGRsPRPGSSA protein degradation; molecular association, regulation; ubiquitination; enzymatic activity, inhibited cell growth, induced; apoptosis, inhibited; autophagy, inhibited ATG13(DISRUPTS); ATG101(DISRUPTS); RB1CC1(DISRUPTS) 31378785 1 5 0 regulates resistance of gliomas to TMZ -DDR1 DDR1 EC 2.7.10.1; KINASE; Kinase, protein; Membrane protein, integral; Protein kinase, TK; Protein kinase, tyrosine (receptor) Q08345 780 6p21.33 human Y586-p 1869973809 GVTGGNTyAVPALPP enzymatic activity, induced 32839343 1 1 0 -CREB1 CREB DNA-binding; Transcription factor P16220 1385 2q33.3 human S257-p 14159739 PGVVMASsPALPTQP molecular association, regulation cell cycle regulation; transcription, induced; transcription, inhibited CBP(INDUCES) DNA(DISRUPTS) 20573984; 23814058; 37098980 4 8 0 -Ilk ILK EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, Ser/Thr (non-receptor); Protein kinase, TKL O55222 16202 7|7 E3 mouse S246-p 479407 CPRLRIFsHPNVLPV PK_Tyr_Ser-Thr enzymatic activity, induced 28739876 8 0 0 -Arhgap18 ARHGAP18 GAP; GAP, Rac/Rho Q8K0Q5 73910 10|10 A4 mouse T156-p 4760950 RVETVSQtLRKKNKQ cytoskeletal reorganization 25456499 1 6 2 spine development -BLNK BLNK Adaptor/scaffold Q8WV28 29760 10q24.1 human Y178-p 447716 LLEDEADyVVPVEDN molecular association, regulation transcription, altered PLCG1(INDUCES); PLCG2(INDUCES); Btk(INDUCES); NCK2(INDUCES); VAV1(INDUCES) 12456653; 9697839 2 3 7 -KHSRP KHSRP RNA-binding Q92945 8570 19p13.3 human S132-p 482096 SQGDSISsQLGPIHP activity, induced; molecular association, regulation 21329876 1 2 12 binds to and functions in pri-miRNA processing -Map2k1 MEK1 EC 2.7.12.2; KINASE; Kinase, protein; Protein kinase, STE; Protein kinase, dual-specificity (non-receptor) Q01986 170851 8q24 rat S298-p 448284 RTPGRPLsSYGMDSR Pkinase intracellular localization; phosphorylation; enzymatic activity, induced cell cycle regulation; cytoskeletal reorganization; cell adhesion, altered 12876277; 17314031 25 4 1 Phosphorylation stimulates autophosphorylation on S217/S222.; activation of MEK1 and ERK1/2 -OTULIN FAM105B EC 3.4.19.12 Q96BN8 90268 5p15.2 human K64-ub 12327312 RAADEIEkEKELLIH protein conformation FAM105B(INDUCES) 35939695 1 4 4 genotoxic stress induces FAM105B dimerization, FAM105B self-deubiquitination, NF-kB Activation -KIF23 KIF23 Microtubule-binding; Motility/polarity/chemotaxis; Motor Q02241 9493 15q23 human S814-p 470674 LRHRRSRsAGDRWVD MKLP1_Arf_bdg molecular association, regulation cell cycle regulation 14-3-3 beta(INDUCES); 14-3-3 zeta(INDUCES); LIMK1(INDUCES) 22580824; 25658096; 25786116 5 7 0 S716 phosphorylation is necessary for S814 phosphorylation; activation of LIMK1 on centrosomes; active S814 dephosphorylation after abscission ; ARF6 can prevent access of 14-3-3 to centralspindlin and preserve the assembly from dissipation by 14-3-3 during cytokinesis. -Npy1r NPY1R GPCR, family 1; Membrane protein, integral; Membrane protein, multi-pass; Receptor, GPCR P21555 29358 16p14 rat T356-p 2815302 IAMSTMHtDVSKTSL receptor desensitization, altered; receptor internalization, altered 15576634 1 0 1 may be an artifact of the truncation mutants -CTNNB1 CTNNB1 Actin-binding; Cell adhesion; Motility/polarity/chemotaxis; Nuclear receptor co-regulator; Oncoprotein; Transcription factor P35222 1499 3p22.1 human T41-p 447583 GIHSGATtTAPSLSG protein degradation; protein stabilization; molecular association, regulation; ubiquitination; intracellular localization; activity, inhibited; neddylation cell cycle regulation; carcinogenesis, induced; carcinogenesis, inhibited; apoptosis, induced; cell growth, inhibited; transcription, induced; cell motility, inhibited; signaling pathway regulation; transcription, altered; cell adhesion, altered; cytoskeletal reorganization; transcription, inhibited; cell growth, altered CBLL1(INDUCES); TRAF2(DISRUPTS) 12000790; 17018282; 19060929; 19667122; 20300119; 20419129; 22025562; 32041324; 32046730; 32210470; 33651074; 33832512; 34117362; 34290402; 34326276; 34749529; 35064015; 35065073; 35108540; 35320710; 35347116; 35879396; 36575468; 36941998; 37369481; 37400529 102 3 0 -PGAM1 PGAM1 Carbohydrate Metabolism - glycolysis and gluconeogenesis; EC 3.1.3.13; EC 5.4.2.11; EC 5.4.2.4; Isomerase; Phosphatase (non-protein) P18669 5223 10q24.1 human H11-p 27939200 YKLVLIRhGESAWNL His_Phos_1 enzymatic activity, induced cell growth, inhibited 15181008; 8477721 4 0 0 PGMtide (LIRHGE) promoted growth arrest of several tumor cell lines, but not in non-tumor cells or in the presence of pyruvate. -NUMA1 NuMA-1 Cell cycle regulation; Motility/polarity/chemotaxis Q14980 4926 11q13.4 human S1969-p 3196643 QETLRRAsMQPIQIA intracellular localization cell cycle regulation 26832443 2 39 43 promotes correct spindle orientation -Fgfr2 FGFR2 EC 2.7.10.1; KINASE; Kinase, protein; Membrane protein, integral; Oncoprotein; Protein kinase, TK; Protein kinase, tyrosine (receptor) P21803 14183 7|7 F3 mouse Y769-p 448113 TLTTNEEyLDLTQPL molecular association, regulation; protein conformation PLCG1(INDUCES) 26687682 5 1 0 -GABBR1 GABBR1 GPCR, family 3; Membrane protein, integral; Membrane protein, multi-pass; Receptor, GPCR Q9UBS5 2550 6p22.1 human K887-ub 54191602 TNNNEEEkSRLLEKE protein degradation; ubiquitination 26817839 1 0 0 -Dclre1c Artemis DNA repair, damage; Deoxyribonuclease; EC 3.1.-.- Q8K4J0 227525 2|2 A1 mouse S518-p 460660 SSIETGGsQSPKLCS cell growth, induced 22476261 8 3 1 -EP300 p300 ACETYLTRANSFERASE; Acetyltransferase; EC 2.3.1.48; Motility/polarity/chemotaxis; Nuclear receptor co-regulator; Transcription, coactivator/corepressor Q09472 2033 22q13.2 human S89-p 447592 SELLRSGsSPNLNMG acetylation; molecular association, regulation; enzymatic activity, inhibited carcinogenesis, induced; cell motility, induced; transcription, induced; transcription, inhibited PPAR-gamma(DISRUPTS); LRP6(INDUCES); RARG(DISRUPTS); TR-beta1(DISRUPTS); RXRA(DISRUPTS) 11020388; 11518699; 12379484; 15006641; 21940946; 26140605; 34261798; 35409338 14 2 0 -IL4R IL4R Membrane protein, integral; Receptor, cytokine P24394 3566 16p12.1 human Y497-p 451065 VIAGNPAyRSFSNSL apoptosis, inhibited 9670964 3 0 0 -IRF8 IRF8 DNA-binding; Transcription factor Q02556 3394 16q24.1 human Y110-p 2299203 ISEPYKVyRIVPEEE IRF transcription, inhibited; transcription, altered 11483597; 18195016 2 0 0 represses PTPN13 promoter activity -Foxo3 FOXO3A Autophagy; DNA-binding; Oncoprotein; Transcription factor Q9WVH4 56484 10 B2|10 22.79 cM mouse T32-p 448602 QSRPRSCtWPLQRPE protein degradation; molecular association, regulation; intracellular localization cell cycle regulation; carcinogenesis, induced; apoptosis, altered; signaling pathway regulation; cell growth, induced; apoptosis, inhibited; cytoskeletal reorganization; transcription, inhibited; cell growth, altered; translation, inhibited 14-3-3 beta(INDUCES); p300(DISRUPTS); 14-3-3 zeta(INDUCES) 10102273; 11154281; 11864996; 11896584; 14981546; 17077388; 19325558; 19942091; 20332342; 21804606; 33795838 74 8 91 -KNL1 CASC5 Cancer Testis Antigen (CTA); Cell cycle regulation Q8NG31 57082 15q15.1 human T1155-p 37046601 GQDDMEItRSHTTAL MELT phosphorylation 25402682 2 1 0 A mutants increased BUB1B S670 -DNM2 DYN2 EC 3.6.5.5; Hydrolase; Microtubule-binding; Motility/polarity/chemotaxis; Vesicle P50570 1785 19p13.2 human S848-p 3059607 GIPPGVPsRRPPAAP molecular association, regulation; intracellular localization PIK3C2A(DISRUPTS) 12205083 2 1 0 -EEF2 EEF2 Translation; Translation elongation P13639 1938 19p13.3 human K529-sm 32005104 EGLKRLAkSDPMVQC EFG_III phosphorylation 24648518 1 0 0 induces tyrosine phosphorylation of itself -JAK2 JAK2 EC 2.7.10.2; KINASE; Kinase, protein; Oncoprotein; Protein kinase, TK; Protein kinase, tyrosine (non-receptor) O60674 3717 9p24.1 human Y119-p 470132 VLYRIRFyFPRWYCS FERM_F1 protein stabilization; enzymatic activity, inhibited EPOR(DISRUPTS) 17024180 2 0 0 -INSIG1 INSIG1 Membrane protein, integral; Membrane protein, multi-pass O15503 3638 7q36.3 human S207-p 1868515111 LWWTFDRsRSGLGLG INSIG activity, induced; protein degradation; molecular association, regulation carcinogenesis, induced; cell growth, induced; apoptosis, inhibited; transcription, induced SCAP(INDUCES) 32322062; 33842305 2 1 0 -Rfc1 RFC1 DNA replication D3ZFT1 89809 14p11 rat S69-p 452680 KKRIIYDsDSESEET intracellular localization transcription, inhibited 10625661 1 64 5 -EPAS1 HIF2A DNA-binding; Transcription factor Q99814 2034 2p21 human K394-sm 12723519 NFLFTKLkEEPEELA transcription, inhibited 20026589 1 0 0 -DNMT1 DNMT1 Amino Acid Metabolism - cysteine and methionine; Cell development/differentiation; EC 2.1.1.37; METHYLTRANSFERASE; Methyltransferase; Methyltransferase, DNA; Transcription regulation P26358 1786 19p13.2 human K160-ac 25171011 PSPRITRkSTRQTTI cell cycle regulation 21947282 1 1 0 -Agtr1 AT1 GPCR, family 1; Membrane protein, integral; Membrane protein, multi-pass; Receptor, GPCR P25095 24180 17p12 rat S335-p 467238 SSLSTKMsTLSYRPS molecular association, regulation ARRB2(INDUCES) 29146594 3 1 0 BRET -XBP1 XBP1 DNA-binding; Transcription factor P17861 7494 22q12.1|22q12 human K77-ub 1878023501 EEKALRRkLKNRVAA bZIP_2 protein degradation; ubiquitination; intracellular localization transcription, inhibited 31837300 1 0 0 K60/77R enhances the nuclear localization, enhances insulin sensitivity in the hepatocyte and in db/db mice, maintains glucose homeostasis in DIO mice, alleviates ER stress in DIO mice, increases its protein abundance, transcriptional activity -TDP2 TTRAP EC 3.1.4.-; Inhibitor; Nucleolus O95551 51567 6p22.3 human S60-p 52421901 EMERALNsYFEPPVE UBA_4 enzymatic activity, induced DNA repair, induced 26701725 1 1 0 -ADIPOR1 ADIPOR1 Membrane protein, integral; Membrane protein, multi-pass Q96A54 51094 1q32.1 human S205-p 1877164900 EKVSRTFsKLDYSGI HlyIII protein degradation; molecular association, regulation; phosphorylation endocytosis, induced; apoptosis, inhibited; signaling pathway regulation LAMP2(INDUCES); RAB5A(INDUCES) 35611695 1 0 0 inhibits APN signaling, resulting in inhibition of ERK, AMPK and ACC phosphorylation -Usp15 USP15 DEUBIQUITINASE; EC 3.4.19.12; Protease; Ubiquitin conjugating system; Ubiquitin-specific protease Q8R5H1 14479 10|10 D2 mouse S678-p 11952926 LPSENENsQSEDSVG UCH molecular association, regulation; ubiquitination; intracellular localization DNA repair, induced MDC1(INDUCES) 30874560 2 1 0 translocate into nuclei following IR, induce genome stability, homologous recombination (HR) repair; deubiquitinates BARD1 -SESN2 SESN2 P58004 83667 1p35.3 human K13-ub 573766050 SECRAELkDYLRFAP protein degradation 31586034 1 2 0 leucine-dependent nutrient sensing -Cdk5 CDK5 Cell cycle regulation; EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, CMGC; Protein kinase, Ser/Thr (non-receptor) P49615 12568 5 A3|5 11.73 cM mouse Y15-p 448022 EKIGEGTyGTVFKAK Pkinase enzymatic activity, induced cell differentiation, induced; transcription, induced; cytoskeletal reorganization; signaling pathway regulation 10896159; 18948252; 21813649; 33798451 17 47 894 -PARD3 PAR3-alpha Adaptor/scaffold; Motility/polarity/chemotaxis Q8TEW0 56288 10p11.22-p11.21 human S827-p 467266 REGFGRQsMSEKRTK phosphorylation PKCI(DISRUPTS) 27554858 7 11 0 apical-junctional polarization -NR5A1 STF-1 Nuclear receptor; Transcription, coactivator/corepressor Q13285 2516 9q33.3 human K194-sm 2798300 AFPGRAIkSEYPEPY sumoylation; molecular association, regulation; intracellular localization transcription, inhibited RAD54L2(INDUCES) DNA(INDUCES) 15192092; 19692572 9 0 0 -USP24 USP24 DEUBIQUITINASE; EC 3.4.19.12; Protease; Ubiquitin-specific protease Q9UPU5 23358 1p32.3 human S2047-p 451983 QRVSDQNsPVLPKKS protein degradation cell cycle regulation 27991932 1 85 3 -Nphs1 NPHS1 Cell adhesion; Immunoglobulin superfamily; Membrane protein, integral Q9QZS7 54631 7|7 B1 mouse Y1232-p 469566 YEDPRGIyDQVAADM molecular association, regulation cytoskeletal reorganization NCK1(INDUCES) 18212058 10 0 0 -ACADVL ACADVL EC 1.3.8.9; Lipid Metabolism - fatty acid; Mitochondrial; Oxidoreductase P49748 37 17p13.1 human K492-sc 40477506 SGLGSALkNPFGNAG molecular association, regulation CRLS1(INDUCES) 25811481 1 0 0 both SIRT3 and SIRT5 KO show reduced afinity for CRLS1 -FOXM1 FOXM1 iso2 DNA-binding; Transcription factor Q08050-2 2305 12p13.33 human S474-p 22648002 PPLEEWPsPAPSFKE ubiquitination 26912724 2 3 0 -MUC1 MUC1 Actin-binding; Cell adhesion; Membrane protein, integral; Motility/polarity/chemotaxis; Nuclear receptor co-regulator; Tumor suppressor P15941 4582 1q22 human Y1203-p 454878 IFPARDTyHPMSEYP activity, induced; molecular association, regulation; intracellular localization cell motility, altered AP2M1(INDUCES); AP1G1(INDUCES); PIK3R1(INDUCES) 15471854; 16507569; 17545600; 17586693 5 7 338 nuclear localization; Phosphorylation enhanced invasion in vitro, through Matrigel. ; Y1203 phosphorylation is necessary for binding of PI3KR1 and phosphorylation of AKt S473. -ESR1 ER-alpha DNA-binding; Nuclear receptor; Transcription factor P03372 2099 6q25.1-q25.2 human K171-ac 31094527 RLASTNDkGSMAMES Oest_recep protein stabilization transcription, induced 30787391 1 2 0 -WIZ WIZ C2H2-type zinc finger protein O95785 58525 19p13.12 human K967-m2 58097619 PAVNKAIkSPPGFSA molecular association, regulation L3MBTL iso4(INDUCES) 23583077 0 2 0 -FYN Fyn EC 2.7.10.2; KINASE; Kinase, protein; Oncoprotein; Protein kinase, TK; Protein kinase, tyrosine (non-receptor) P06241 2534 6q21 human Y185-p 465282 SETTKGAySLSIRDW SH2 molecular association, regulation; enzymatic activity, induced 27001024 1 29 286 autophosphorylation reduces its ability to bind to ESDN/DCBLD2; reduces SH2-dependent binding interactions -KDR VEGFR2 EC 2.7.10.1; KINASE; Kinase, protein; Membrane protein, integral; Protein kinase, TK; Protein kinase, tyrosine (receptor) P35968 3791 4q12 human R819-me 1878245900 PLDEHCErLPYDASK molecular association, regulation; phosphorylation cytoskeletal reorganization Src(INDUCES) 35942094 1 0 0 mediates filopodia in endothelial cells; induces phosphorylation at Y822 -HRAS HRas G protein; G protein, monomeric; G protein, monomeric, Ras; Motility/polarity/chemotaxis; Oncoprotein P01112 3265 11p15.5 human T35-p 450197 FVDEYDPtIEDSYRK Ras apoptosis, induced 9264402 1 0 0 -Mbp MBP iso5 Cytoskeletal P04370-5 17196 18 E3|18 55.84 cM mouse T93-p 455362 HFFKNIVtPRTPPPS Myelin_MBP molecular association, regulation; intracellular localization; protein conformation cytoskeletal reorganization Fyn(DISRUPTS) 21887699; 23861868 5 2 0 -PRKDC DNAPK DNA repair, damage; EC 2.7.11.1; KINASE; Kinase, protein; Nucleolus; Protein kinase, Ser/Thr (non-receptor); Protein kinase, atypical P78527 5591 8q11.21 human K3260-ac 11318529 SLAMKLLkELHKESK FAT DNA repair, induced 27297111 1 3 0 regulates genomic stability and radiosensitivity of cells -Gpsm2 GPSM2 G protein regulator, misc. Q8VDU0 76123 3|3 F3 mouse S408-p 4766076 AKLGRRHsMENLELM molecular association, regulation DLG1(INDUCES) 22117215 2 21 9 Fluorescence Polarization -SOCS3 SOCS3 Inhibitor O14543 9021 17q25.3 human Y204-p 450446 VNGHLDSyEKVTQLP protein degradation; molecular association, regulation transcription, altered TCEB1(DISRUPTS) 12783885; 16352613 5 2 12 -CYCS CYCS Apoptosis; Mitochondrial; Oxidoreductase; PHOSPHATASE; Protein phosphatase, Ser/Thr (non-receptor) P00004 100053958 horse K9-ac 467108 GDVEKGKkIFVQKCA Cytochrom_C enzymatic activity, induced 19645667 1 4 0 -ROS1 ROS EC 2.7.10.1; KINASE; Kinase, protein; Membrane protein, integral; Oncoprotein; Protein kinase, TK; Protein kinase, tyrosine (receptor) P08922 6098 6q22.1 human Y2334-p 454392 GKPEGLNyACLTHSG molecular association, regulation SHP-1(INDUCES) 15456853 1 3 17 Mutation of Y2334 reduced constitutive association of ROS with SHP-1. -CLTC CLTC Motility/polarity/chemotaxis; Vesicle Q00610 1213 17q23.1 human Y1477-p 448069 LFITEEDyQALRTSI Clathrin molecular association, regulation; intracellular localization Syk(INDUCES) 10089883; 19289168 2 11 156 -EIF4EBP2 4E-BP2 Translation; Translation initiation Q13542 1979 10q22.1 human T37-p 449367 LPHDYCTtPGGTLFS eIF_4EBP molecular association, regulation; protein conformation 4E-BP1(DISRUPTS) 25533957 4 26 44 -XRCC4 XRCC4 DNA repair, damage Q13426 7518 5q14.2 human K210-sm 3656303 QEREKDIkQEGETAI XRCC4 intracellular localization DNA repair, induced 16478998; 25934149 2 0 0 -MCL1 MCL1 Apoptosis; Channel, misc.; Inhibitor; Membrane protein, integral; Mitochondrial Q07820 4170 1q21.2 human S162-p 59032201 STDGSLPsTPPPAEE protein stabilization 27738316 1 0 0 -GCH1 GCH1 Cofactor and Vitamin Metabolism - folate biosynthesis; EC 3.5.4.16; Hydrolase P30793 2643 14q22.2 human S81-p 487495 AYSSILSsLGENPQR GTP_cyclohydroI molecular association, regulation; enzymatic activity, induced GCHFR(DISRUPTS) 17704208; 19926872 4 0 0 -Cacna1e CACNA1E Channel, calcium; Membrane protein, integral; Membrane protein, multi-pass Q07652 54234 13q21 rat S1995-p 455594 GGRERGRsKERKHLL activity, induced 15840578 1 0 0 potentiation of Ca(2+) currents -F3 F3 Cell surface; Membrane protein, integral P13726 2152 1p21.3 human S285-p 451611 RKAGVGQsWKENSPL molecular association, regulation; ubiquitination; intracellular localization; protein conformation; phosphorylation apoptosis, altered; cell motility, altered; cell growth, altered FLNA(INDUCES) 12920028; 15039423; 15630487; 18297283; 20076769; 21310953; 27599717; 29044292 10 0 0 promotes angiogenesis; accelerates the incorporation of F3 into microparticles and induces S290 phosphorylation -PAK2 PAK2 EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, STE; Protein kinase, Ser/Thr (non-receptor) Q13177 5062 3q29 human S64-p 4760282 FSGTEKGsKKKEKER carcinogenesis, inhibited; signaling pathway regulation 30131370 1 10 0 -Slc12a5 KCC2 iso2 Membrane protein, integral; Membrane protein, multi-pass; Transporter; Transporter, SLC family Q91V14-2 57138 2|2 H3 mouse S932-p 27723627 EREREIQsITDESRG SLC12 activity, induced 30201606 2 2 0 transport activity increased -Rock2 ROCK2 EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, AGC; Protein kinase, Ser/Thr (non-receptor) P70336 19878 12|12 A1.1 mouse Y722-p 464192 LADKNKIyESIEEAK molecular association, regulation cell motility, altered; cytoskeletal reorganization RHOA(DISRUPTS) 20826462 5 7 127 -PTGIR PTGIR GPCR, family 1; Membrane protein, integral; Membrane protein, multi-pass; Receptor, GPCR P43119 5739 19q13.32 human S328-p 450985 TPLSQLAsGRRDPRA receptor desensitization, altered 9722557 3 0 0 S328A mutant had markedly reduced level of desensitization -Pde4b PDE4B EC 3.1.4.53; Nucleotide Metabolism - purine; Phosphodiesterase P14646 24626 5q33 rat S133-p 449097 GHSQRREsFLYRSDS enzymatic activity, induced 12441002 4 22 1 -Sp1 SP1 C2H2-type zinc finger protein; DNA-binding; Transcription factor Q01714 24790 7q36 rat T740-p 448227 SEGSGTAtPSALITT transcription, induced 21115498 17 1 0 induced by carbon monoxide -ZAP70 ZAP70 EC 2.7.10.2; KINASE; Kinase, protein; Protein kinase, TK; Protein kinase, tyrosine (non-receptor) P43403 7535 2q11.2 human Y292-p 447586 DTLNSDGyTPEPARI protein degradation; molecular association, regulation; intracellular localization; enzymatic activity, inhibited; phosphorylation cell adhesion, altered; transcription, altered; cell growth, altered CBL(INDUCES) 10779765; 11514605; 11976341; 15100278; 17579062; 8756661 10 14 447 leads to decreased LAT, Cbl, CD3-Zeta, and PLC-gamma-1 phosphorylation; inhibits Ca(2+) mobilization; inhibits PI3K activation and adhesion -A1cf ACF Hydrolase; RNA processing; RNA-binding Q923K9 170912 1q52 rat S368-p 473055 PATKGHLsNRALIRT activity, induced 17229474 1 0 0 enhances ApoB mRNA editing -HSP90AB1 HSP90B Chaperone; Heat shock protein P08238 3326 6p21.1 human S255-p 449266 PKIEDVGsDEEDDSG HSP90 activity, induced; molecular association, regulation; protein processing; intracellular localization; protein conformation apoptosis, altered; apoptosis, induced HSP40(DISRUPTS); AHSA1(DISRUPTS); PXR(INDUCES); APAF(DISRUPTS); CACYBP(INDUCES); DNAJC7(DISRUPTS); HSC70(DISRUPTS); CDC37(DISRUPTS); GR(DISRUPTS) 18591256; 25995454; 29854279; 34359868 10 131 410 induced by triptolide -Tdg TDG DNA repair, damage; EC 3.2.2.29; Hydrolase; Nuclear receptor co-regulator P56581 21665 10 C1|10 39.72 cM mouse K94-ac 458994 PKKPATSkKSGKSTK molecular association, regulation; acetylation; phosphorylation DNA repair, induced; chromatin organization, altered; DNA repair, inhibited; transcription, induced APE1(DISRUPTS) DNA(DISRUPTS) 11864601; 19966277 2 1 0 inhibits phosphorylation at other sites; histone acetylation -TSC2 TSC2 Cell cycle regulation; GAP; GAP, misc.; Nuclear receptor co-regulator; Tumor suppressor P49815 7249 16p13.3 human R1457-me 1877221602 PRSPSGLrPRGYTIS protein stabilization; phosphorylation signaling pathway regulation 33273660 1 0 0 mTOR activity; inhibits phosphorylation -Epor EPOR Membrane protein, integral; Receptor, cytokine Q07303 24336 8q13 rat Y455-p 455532 PPHLKYLyLVVSDSG signaling pathway regulation 25219375 8 0 0 promotes cell survival -MAPT Tau iso3 ACETYLTRANSFERASE; Acetyltransferase; Cytoskeletal P10636-3 4137 17q21.31 human S271-p 449081 GAEIVYKsPVVSGDT molecular association, regulation cytoskeletal reorganization 10747907 192 49 90 regulates association with membrane -CDCA8 Borealin Cell cycle regulation; Nucleolus Q53HL2 55143 1p34.3 human S219-p 460351 YNISGNGsPLADSKE Borealin protein degradation cell cycle regulation 20803554; 22383538 3 53 2 -PINK1 PINK1 EC 2.7.11.1; KINASE; Kinase, protein; Membrane protein, integral; Mitochondrial; Protein kinase, Other; Protein kinase, Ser/Thr (non-receptor) Q9BXM7 65018 1p36.12 human K137-ub 964535576 AIFTQKSkPGPDPLD protein degradation 28683321 1 2 0 -Ets2 Ets-2 DNA-binding; Oncoprotein; Transcription factor P15037 23872 16 C4|16 56.64 cM mouse T72-p 447688 SCELPLLtPCSKAVM activity, induced apoptosis, inhibited; transcription, induced; transcription, altered 11027273; 14612405; 15240733 9 0 0 Inflammation was attenuated in the Ets2 A72/A72 Hcph me-v/me-v mice -GAREM1 GAREM Adaptor/scaffold Q9H706 64762 18q12.1 human Y453-p 450613 PGKSELPyEELWLEE molecular association, regulation cell growth, altered GRB2(INDUCES); SHP-2(INDUCES) 19509291 1 18 96 -NFKBIA IkB-alpha DNA-binding; Inhibitor P25963 4792 14q13.2 human K22-sm 2798312 GPRDGLKkERLLDDR protein stabilization transcription, inhibited 17956732 1 0 0 inhibits NF-kB transcriptional activity -NANOG NANOG Cell development/differentiation; DNA-binding; Transcription factor Q9H9S0 79923 12p13.31 human Y174-p 25240300 QKASAPTyPSLYSSY activity, induced carcinogenesis, induced; cell motility, induced; cell growth, induced 22493428 1 0 0 increased lamellipodia and filopodia formation and increased cell polarization -CDC25A CDC25A EC 3.1.3.48; Motility/polarity/chemotaxis; PHOSPHATASE; Protein phosphatase, dual-specificity P30304 993 3p21.31 human S79-p 450247 QRMGSSEsTDSGFCL protein degradation; molecular association, regulation; ubiquitination; phosphorylation BTRC(INDUCES) 14681206; 19734889; 20348946 3 0 0 S76, S79, and S82 phosphorylation affect binding to BTRC; S79 phosphorylation by CK1-A primes for S82 phosphorylation by CK1-A; S79 phosphorylation is dependent on S76. -Atp5po ATP5O EC 3.6.3.14; Energy Metabolism - oxidative phosphorylation; Hydrolase; Mitochondrial Q9DB20 28080 16|16 C4 mouse K70-ac 467176 LRVGQLLkDPKVSLA OSCP activity, induced; molecular association, regulation PPID(INDUCES) 27489254 1 8 8 induce sensitization of opening of mitochondrial permeability transition pore -CEACAM1 CEACAM1 Cell adhesion; Immunoglobulin superfamily; Membrane protein, integral; Motility/polarity/chemotaxis P13688 634 19q13.2 human Y493-p 447777 NKMNEVTySTLNFEA molecular association, regulation ITGB3(INDUCES) 11485912 10 2 0 -DDC DDC Amino Acid Metabolism - histidine; Amino Acid Metabolism - phenylalanine; Amino Acid Metabolism - tryptophan; Amino Acid Metabolism - tyrosine; EC 4.1.1.28; Lyase; Nuclear receptor co-regulator P20711 1644 7p12.2-p12.1 human S193-p 1883995300 YSSDQAHsSVERAGL enzymatic activity, induced 37651872 1 0 0 -Prlr PRLR Membrane protein, integral; Receptor, cytokine P05710 24684 2q16 rat Y599-p 450273 LQLGRLDyLDPTCFM phosphorylation transcription, altered 7537382; 9516478 3 1 5 -IFI16 IFI16 Transcription factor Q16666 3428 1q23.1 human K4-ub 1877844702 ____MGKkYKNIVLL protein degradation signaling pathway regulation STING(INDUCES) 31665637 1 1 0 IFI16 degradation inhibits viral DNA-induced IFN-I production -LMNA lamin A/C Cytoskeletal P02545 4000 1q22 human S392-p 452606 ERLRLSPsPTSQRSR activity, induced; protein degradation; molecular association, regulation; intracellular localization cell cycle regulation 18815303; 24741066; 30190500; 7925482 11 105 85 dominant negative mitotic affects, and mitotic assembly and disassembly of lamin -Hist1h2ail1 H3 DNA-binding Q6LED0 291159 17p11 rat K4-m2 459004 ____ARTkQTARKST Histone transcription, induced 19476549 108 10 0 -Irs1 IRS1 Adaptor/scaffold; Motility/polarity/chemotaxis P35570 25467 9q34 rat S24-p 455604 GYLRKPKsMHKRFFV PH molecular association, regulation; intracellular localization cell growth, altered Other(DISRUPTS) 16574739 2 2 0 disrupts binding to PI(4,5)P2 in vitro -GPS1 COPS1 G protein regulator, misc. Q13098 2873 17q25.3 human S474-p 467704 KSPPREGsQGELTPA apoptosis, induced 26986008 1 58 84 UV induced apoptosis -Rbck1 RBCK1 EC 6.3.2.-; Ligase; UBIQUITIN LIGASE; Ubiquitin conjugating system; Ubiquitin ligase Q9WUB0 24105 2|2 G3 mouse T207-p 2103605 CTFINKPtRPGCEMC molecular association, regulation; protein conformation ubiquitin(DISRUPTS) 37595872 2 0 0 -MAPT Tau iso8 ACETYLTRANSFERASE; Acetyltransferase; Cytoskeletal P10636-8 4137 17q21.31 human S422-p 449083 GSIDMVDsPQLATLA O-GlcNAc glycosylation; molecular association, regulation; protein processing; phosphorylation cell growth, inhibited; cytoskeletal reorganization; transcription, inhibited Tau iso8(INDUCES); Tau(INDUCES) 15190058; 15664690; 16606369; 16923168; 19451179; 30734106; 33710538; 35857446 41 10 0 -VASP VASP Cytoskeletal; Motility/polarity/chemotaxis P50552 7408 19q13.32 human S157-p 448379 EHIERRVsNAGGPPA activity, induced; molecular association, regulation; intracellular localization; protein conformation carcinogenesis, induced; carcinogenesis, inhibited; cell motility, induced; cell motility, inhibited; cell adhesion, altered; cytoskeletal reorganization; transcription, inhibited; cell growth, altered VASP(INDUCES); Vinculin(INDUCES); SPTAN1(DISRUPTS); CRKL(DISRUPTS) 11919161; 14679200; 15178555; 18195108; 18637808; 20463151; 23846685; 25759389; 25961942; 26336132; 27620165; 33737052; 33755220; 37335130 55 4 0 -RB1 Rb Nuclear receptor co-regulator; Oncoprotein; Transcription, coactivator/corepressor; Tumor suppressor P06400 5925 13q14.2 human S811-p 448717 IYISPLKsPYKISEG Rb_C protein degradation; molecular association, regulation; ubiquitination; phosphorylation cell cycle regulation; carcinogenesis, induced; cell growth, induced; transcription, induced; transcription, altered; cell growth, altered ID2(DISRUPTS); E2F1(DISRUPTS); SETDB1(DISRUPTS); Abl iso2(DISRUPTS) 10969768; 15028555; 15619620; 16007177; 25698448; 32093423; 32094692; 33556114; 34108622; 34209868; 34247189; 35194151; 35235778; 35437308; 36603130; 36637424; 8626527; 9315635 96 40 80 -DGKA DGKA EC 2.7.1.107; Kinase, lipid; Lipid Metabolism - glycerolipid; Lipid Metabolism - glycerophospholipid; Motility/polarity/chemotaxis P20192 397097 pig Y217-p 22874703 KRFPRPVyCNLCESS C1_1 intracellular localization 22199356 1 0 2 necessary for serum-induced export from nucleus to cytoplasm -APOBEC1 APOBEC1 Cell cycle regulation; EC 3.5.4.-; Hydrolase; RNA processing; RNA-binding P41238 339 12p13.31 human S47-p 448433 YEIKWGMsRKIWRSS APOBEC4_like enzymatic activity, induced 11463337 1 0 0 -AR AR DNA-binding; Nuclear receptor; Transcription factor P10275 367 Xq12 human K619-ac 59149200 CPSCRLRkCYEAGMT zf-C4 molecular association, regulation; intracellular localization carcinogenesis, induced; cell growth, induced; transcription, induced HSP90A(DISRUPTS); POLR2A(INDUCES) DNA(INDUCES) 27659526 1 0 0 -KPNA4 KPNA4 Adaptor/scaffold; Chaperone; Karyopherin; Nuclear import O00629 3840 3q25.33 human S60-p 469763 HEDICEDsDIDGDYR IBB activity, induced; molecular association, regulation cell growth, induced; signaling pathway regulation RREB1(INDUCES) 31822798 1 39 6 Ras/ERK signaling -TPT1 TPT1 Calcium-binding; Microtubule-binding P13693 7178 13q14.13 human S46-p 476067 TEGNIDDsLIGGNAS TCTP protein degradation; molecular association, regulation; protein conformation carcinogenesis, inhibited; apoptosis, induced TPT1(INDUCES) 29719201; 34472703; 34675258 8 11 9 -XRCC6 Ku70 DNA repair, damage; DNA-binding; EC 3.6.4.-; EC 4.2.99.-; Helicase; Nuclear receptor co-regulator; RNA-binding P12956 2547 22q13.2 human Y530-p 463414 DEFKELVyPPDYNPE Ku_C apoptosis, inhibited 27998981 1 1 1 -SERPINF1 PEDF Inhibitor; Secreted; Secreted, signal peptide P36955 5176 17p13.3 human S114-p 455232 ALYYDLIsSPDIHGT Serpin molecular association, regulation apoptosis, altered; carcinogenesis, altered; cell motility, altered LEPR(INDUCES) 21059648 2 0 0 -HSPB6 HSP20 Chaperone; Heat shock protein O14558 126393 19q13.12 human S16-p 450706 PSWLRRAsAPLPGLS Crystallin molecular association, regulation; protein conformation apoptosis, inhibited; cell motility, inhibited; cytoskeletal reorganization 14-3-3 zeta(INDUCES) 15829720; 17084643; 18790732; 22731613; 22794279; 25446653; 27046040 21 31 2 -MAPT Tau iso8 ACETYLTRANSFERASE; Acetyltransferase; Cytoskeletal P10636-8 4137 17q21.31 human S235-p 449080 VVRTPPKsPSSAKSR molecular association, regulation; intracellular localization; phosphorylation cytoskeletal reorganization TUBA4A(DISRUPTS); Fyn(DISRUPTS); Tau iso8(INDUCES) 15190058; 16115884; 16687396; 20550628 45 36 25 regulates phosphorylation of tau S199 and S262; Phosphotylated sites found in the somato-dendritic campartment but not in the axon, where tau was not phosphorylated (T205 and T217), or not simultaneously phosphorylated (T231 and 235). -GLE1 GLE1 Karyopherin; Nuclear export Q53GS7 2733 9q34.11 human S88-p 12667856 QPSFVPKsPDASSAF molecular association, regulation GLE1(INDUCES) 30429220 1 13 2 self-association stress granules' assembly and disassembly, DDX3-ATPase activity inhibited -Mef2c MEF2C DNA-binding; Transcription factor Q8CFN5 17260 13 C3|13 43.68 cM mouse K4-ac 12718500 ____MGRkKIQITRI molecular association, regulation cell differentiation, induced; transcription, induced DNA(INDUCES) 18086704 1 1 0 -IRF3 IRF3 DNA-binding; Transcription factor Q14653 3661 19q13.33 human S173-p 6370303 PCPQPLRsPSLDNPT molecular association, regulation; phosphorylation transcription, inhibited; transcription, altered IRF7(INDUCES) 19153595; 23685991; 24275658 6 8 0 Formation of IRF3:IRF7 dimers -SREBF2 SREBP-2 DNA-binding; Membrane protein, integral; Membrane protein, multi-pass; Transcription factor Q12772 6721 22q13.2 human S455-p 451008 SIDSEPGsPLLDDAK sumoylation transcription, induced 14988395; 18403372 2 0 0 inhibits sumoylation, leading to enhanced transcriptional activation -Foxo1 FOXO1A DNA-binding; Nuclear receptor co-regulator; Oncoprotein; Transcription factor Q9R1E0 56458 3 C|3 23.19 cM mouse S295-p 471972 QFSKWPAsPGSHSND molecular association, regulation; intracellular localization transcription, inhibited DUSP6(INDUCES) 22503562; 22848439 6 12 30 -Neto2 NETO2 Adaptor/scaffold; Membrane protein, integral C6K2K4 307757 rat S409-p 4752528 SLREKEIsADLADLS neural plasticity 28717010 1 4 1 synaptic targeting of GluK1 is inhibited -DVL3 DVL3 Motility/polarity/chemotaxis Q92997 1857 3q27.1 human S280-p 34668101 DGGIYIGsIMKGGAV PDZ activity, induced; intracellular localization transcription, induced 24993822; 27486244 2 2 0 -OSMR OSMR Membrane protein, integral; Receptor, cytokine Q99650 9180 5p13.1 human Y945-p 1930202 EAPHCSEyKMQMAVS phosphorylation 18430728 2 0 0 important for STAT3 activation -PCK1 PCK1 Carbohydrate Metabolism - citrate (TCA) cycle; Carbohydrate Metabolism - glycolysis and gluconeogenesis; Carbohydrate Metabolism - pyruvate; EC 4.1.1.32; KINASE; Kinase, other; Lyase; Protein kinase, Ser/Thr (non-receptor) P35558 5105 20q13.31 human K91-ac 1880915300 DVARIESkTVIVTQE enzymatic activity, induced 30193097 1 1 0 -ATF2 ATF-2 ACETYLTRANSFERASE; C2H2-type zinc finger protein; EC 2.3.1.48; Transcription factor P15336 1386 2q31.1 human K374-ac 1910101 SRCRQKRkVWVQSLE bZIP_1 transcription, induced 17590016 1 1 0 -ROCK2 ROCK2 EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, AGC; Protein kinase, Ser/Thr (non-receptor) Q28021 282041 cow S1099-p 1732202 QAQIAEEsQIRIELQ enzymatic activity, induced cell cycle regulation 17446864 1 0 0 alanine mutation of all 4 sites -Eef1a1 EEF1A1 Nucleolus; Translation; Translation elongation P10126 13627 9|9 E1 mouse K165-m2 3898709 TEPPYSQkRYEEIVK GTP_EFTU molecular association, regulation translation, altered EEF1D(DISRUPTS); eEF1B(DISRUPTS); EEF1G(DISRUPTS) 28108655 1 7 12 -SIRT1 SIRT1 Apoptosis; DEACETYLASE; Deacetylase; EC 3.5.1.-; Nuclear receptor co-regulator Q96EB6 23411 10q21.3 human S540-p 4770118 HVSEDSSsPERTSPP acetylation; intracellular localization; enzymatic activity, induced cell cycle regulation; cytoskeletal reorganization 19107194; 30517871 2 5 4 suppress centriole duplication -Hmga1 HMGA1 DNA-binding Q8K585 117062 20p12 rat S64-p 3136103 PRGRPKGsKNKGTAK molecular association, regulation DNA(DISRUPTS) 10617144 1 1 0 -MLXIPL ChREBP Transcription factor Q9NP71 51085 7q11.23 human S140-p 2103610 QYVKRRKsPVCGFVT molecular association, regulation; intracellular localization 14-3-3 beta(INDUCES); KPNA2(DISRUPTS) 23918932 3 1 0 regulates lipogenesis -Sp7 osterix C2H2-type zinc finger protein; DNA-binding; Transcription factor Q8VI67 170574 15|15 F3 mouse K386-ub 40477507 GPPPSGPkELGEGRS protein degradation cell differentiation, inhibited; transcription, induced 25818514 1 0 0 inhibits BMP signaling -PHGDH PHGDH Amino Acid Metabolism - glycine, serine and threonine; Cell development/differentiation; EC 1.1.1.95; Oxidoreductase O43175 26227 1p12 human K146-ub 12338481 MGTELNGkTLGILGL 2-Hacid_dh; 2-Hacid_dh_C enzymatic activity, induced cell motility, induced; cell adhesion, induced; transcription, induced 34720086 2 6 4 SETD1A-mediated increase H3K9m3, increasing cell adhesion gene transcription and promoting CRC metastasis; expressions of cell adhesion genes LAMC2 and CYR61 -GBF1 GBF1 GEF; GEF, ARF Q92538 8729 10q24.32 human S292-p 1170755600 VVSPSTDsGLEFSSQ protein degradation; molecular association, regulation; ubiquitination; intracellular localization cell cycle regulation; cytoskeletal reorganization BTRC(INDUCES) 29898406 1 1 0 -CEP250 CEP250 Cell cycle regulation Q9BV73 11190 20q11.22 human S2394-p 4728460 LHHSLSHsLLAVAQA cell cycle regulation 20708153 1 2 0 -CA9 CA9 EC 4.2.1.1; Energy Metabolism - nitrogen; Lyase; Membrane protein, integral; Nucleolus Q16790 768 9p13.3 human S448-p 3197489 RGTKGGVsYRPAEVA molecular association, regulation; enzymatic activity, inhibited MMP14(INDUCES) 22037869; 28692057 2 5 0 -HDAC4 HDAC4 DEACETYLASE; Deacetylase; EC 3.5.1.98; Hydrolase; Nuclear receptor co-regulator; SUMO LIGASE P56524 9759 2q37.3 human S350-p 14314314 LPLYTSPsLPNITLG molecular association, regulation 14-3-3 gamma(INDUCES); ANKRA2(DISRUPTS) 22649097 1 4 2 a phospho-controlled switch alternating association ANKRA2 and 14-3-3 gamma -Klf1 KLF1 C2H2-type zinc finger protein; DNA-binding; Transcription factor P46099 16596 8 41.3 cM|8 C3 mouse K56-sm 2798306 PSLHVSLkSEDPSGE sumoylation; molecular association, regulation; intracellular localization cell differentiation, inhibited; carcinogenesis, inhibited; transcription, inhibited KPNB1(INDUCES); CHD-4(INDUCES) 17938210; 24576425; 35822667 3 0 0 KLF1(K54R) knockin delays the onset of age-related disorders, knockin HSCs potentiate antiaging and lifespan extension, suppresses tumor metastasis and tumorigenesis in vivo -RPTOR Raptor Adaptor/scaffold Q8N122 57521 17q25.3 human S722-p 2314601 PRLRSVSsYGNIRAV cell cycle regulation; autophagy, induced; transcription, altered 21900751; 34604061 9 52 7 -Naca NACA iso2 Motility/polarity/chemotaxis; Transcription, coactivator/corepressor Q60817 17938 10|10 D3 mouse S132-p 471099 EAKIEDLsQQAQLAA molecular association, regulation transcription, inhibited TXLNG(INDUCES); HDAC2(INDUCES) 24375853 1 5 18 -DTD1 DTD1 DNA replication; EC 3.1.-.-; Hydrolase Q8TEA8 92675 20p11.23 human S182-p 36396301 AKGPSESsKERNTPR molecular association, regulation cell cycle regulation; cell growth, induced MCM7(INDUCES); MCM3(DISRUPTS) 25258324 1 0 0 decreases DTD1 incorporation into HMW, supports DNA replication initiation -ZNF148 ZNF148 C2H2-type zinc finger protein; DNA-binding; Transcription, coactivator/corepressor Q9UQR1 7707 3q21.2 human K115-sm 2798308 LNVPISVkQEITFTD transcription, inhibited 17940278 1 1 0 -TNNI3 TNNI3 Actin-binding; Motility/polarity/chemotaxis; Motor P19429 7137 19q13.42 human S24-p 448424 APIRRRSsNYRAYAT Troponin-I_N activity, induced; molecular association, regulation; activity, inhibited cytoskeletal reorganization TNNC1(DISRUPTS) 15134451; 24116014; 24585778; 27557662; 28018230; 8543035 64 12 16 increased myofilament length ; muscle contraction -Slc15a2 SLC15A2 Membrane protein, integral; Membrane protein, multi-pass; Transporter; Transporter, SLC family Q9ES07 57738 16|16 B3 mouse K139-sm 1881396700 AIPILGGkMLHTILS intracellular localization 34881291 1 1 0 localized to the apical membrane of DCT cells -SUFU SUFU Adaptor/scaffold; Transcription, coactivator/corepressor; Tumor suppressor Q9UMX1 51684 10q24.32 human S346-p 4786848 RAPSRKDsLESDSST SUFU_C molecular association, regulation; protein stabilization; intracellular localization; phosphorylation FBXL17(DISRUPTS) 21317289; 27234298 4 30 3 -Thrap3 Trap150 RNA-binding; Transcription, coactivator/corepressor Q569Z6 230753 4|4 D2.2 mouse S243-p 452511 RASVSDLsPRERSPA THRAP3_BCLAF1 molecular association, regulation PPAR-gamma(INDUCES) 34526909 1 114 33 -Rps6kb2 P70S6KB EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, AGC; Protein kinase, Ser/Thr (non-receptor); Translation Q9Z1M4 58988 19|19 A mouse T420-p 468357 RLNSSPRtPISPLKF phosphorylation 17980619 1 5 3 -KAT2B PCAF ACETYLTRANSFERASE; Acetyltransferase; EC 2.3.1.48; Nuclear receptor co-regulator Q92831 8850 3p24.3 human K416-ac 458984 GSSSPACkASSGLEA enzymatic activity, induced 12888487 1 0 0 in vitro -PRMT5 PRMT5 Cell cycle regulation; EC 2.1.1.125; METHYLTRANSFERASE; Methyltransferase; Methyltransferase, protein arginine; RNA processing O14744 10419 14q11.2 human Y324-p 1869973804 DNLESQTyEVFEKDP PRMT5 protein degradation; molecular association, regulation; methylation; enzymatic activity, inhibited; phosphorylation apoptosis, induced; DNA repair, inhibited Other(DISRUPTS) 32759981 1 0 0 inhibits methylation further inducing degradation of 53BP1, induces dephosphorylation of H2AX, inhibits binding to S-adenosyl methionine -Ppp2r5b PPP2R5B Motility/polarity/chemotaxis; Protein phosphatase, regulatory subunit Q6PD28 225849 19|19 A mouse S35-p 10405458 VDGFSRRsLRRARPR molecular association, regulation; phosphorylation PPP2CA(INDUCES); PPP2R5B(INDUCES) 21329884 1 0 1 PPP2R2R5B phosphorylation by CLK2 is required for the PPP2CA-AKT complex; induces AKT dephosphorylation -CALD1 Caldesmon Actin-binding Q05682 800 7q33 human S789-p 448466 QSVDKVTsPTKV___ intracellular localization cell motility, altered; cytoskeletal reorganization 16289153; 17562849; 20128924 19 19 0 -Rorc RORC iso2 DNA-binding; Nuclear receptor; Transcription factor P51450-2 19885 3|3 F2.1 mouse K256-ub 41494427 YLVQNVCkSFRETCQ molecular association, regulation transcription, induced; signaling pathway regulation DNA(INDUCES) 36269826 1 1 0 RORC-K256R impairs the signaling pathway for the pathogenesis of EAE but not for the TH17 differentiation; K256 fails to bind to and activate Runx1 expression critical for TH17-mediated EAE -Gja1 GJA1 Channel, misc.; Membrane protein, integral; Membrane protein, multi-pass; Motility/polarity/chemotaxis P23242 14609 10 B4|10 28.64 cM mouse S255-p 448852 HATTGPLsPSKDCGS protein degradation; ubiquitination endocytosis, induced 24612377 23 21 1 -Pde4d PDE4D iso6 EC 3.1.4.53; Nucleotide Metabolism - purine; Phosphodiesterase P14270-6 24627 rat S81-p 33670300 KSMSRNSsIASDIHG cell cycle regulation 24815749 1 0 0 -STAT1 STAT1 DNA-binding; Transcription factor P42224 6772 2q32.2 human Y701-p 447754 DGPKGTGyIKTELIS activity, induced; protein degradation; sumoylation; molecular association, regulation; intracellular localization; protein conformation cell cycle regulation; carcinogenesis, induced; carcinogenesis, inhibited; cell growth, inhibited; transcription, induced; signaling pathway regulation; transcription, altered; cell differentiation, altered; apoptosis, inhibited; transcription, inhibited; cell growth, altered STAT2(INDUCES); PIAS1(INDUCES); STAT1(INDUCES); DUX4(INDUCES) DNA(INDUCES); DNA(DISRUPTS) 10921891; 11023524; 11316742; 11777927; 11823427; 12637327; 12807916; 14962955; 15051500; 15767445; 15994321; 17442890; 18566411; 19088846; 19174562; 23043228; 24882218; 25921060; 33472080; 34233951; 34358560; 34379505; 35154579; 35196494; 35361236; 35568036; 35705809; 36166512; 36203966; 36288705; 37092726; 8197134; 9724754 204 7 64 PIAS1 inhibits DNA binding activity of STAT1. -FBXW7 FBXW7 Motility/polarity/chemotaxis; Nucleolus; UBIQUITIN LIGASE; Ubiquitin conjugating system; Ubiquitin ligase Q969H0 55294 4q31.3 human S25-p 25126710 SLRGNPSsSQVDEEQ protein degradation cytoskeletal reorganization 22399798 1 1 0 Phosphorylation prevents ubiquitin-dependent degradation of cyclin E and subsequent centriole duplication. -KAT2B PCAF ACETYLTRANSFERASE; Acetyltransferase; EC 2.3.1.48; Nuclear receptor co-regulator Q92831 8850 3p24.3 human K720-ac 1876931100 PSGKEKSkEPRDPDQ molecular association, regulation cell cycle regulation MDM2(DISRUPTS) 32404984 1 0 0 -RRM2 RRM2 EC 1.17.4.1; Nucleotide Metabolism - purine; Nucleotide Metabolism - pyrimidine; Other Amino Acids Metabolism - glutathione; Oxidoreductase P31350 6241 2p25.1 human Y221-p 464201 IGDKEATyGERVVAF Ribonuc_red_sm enzymatic activity, induced 20484015 1 0 1 -Psmc5 RPT6 Nuclear receptor co-regulator; Proteasome complex; Ubiquitin conjugating system P62198 81827 10q32.1 rat S120-p 483970 RVALRNDsYTLHKIL Prot_ATP_ID_OB protein degradation; activity, inhibited; phosphorylation neural plasticity; cytoskeletal reorganization; transcription, inhibited; signaling pathway regulation 22496558; 22726833; 24009566; 35842713 11 7 0 inhibits IKB phosphorylation and the NF-kB signalling pathway; proteasome-dependent dendritic spine growth; memory -KIF11 KIF11 Microtubule-binding; Motor P52732 3832 10q23.33 human Y125-p 4251398 ERSPNEEyTWEEDPL Kinesin cytoskeletal reorganization 28646493 1 3 9 spindle morphology -Rfc1 RFC1 DNA replication D3ZFT1 89809 14p11 rat S245-p 468617 TKKARKDsEEGESFS transcription, induced 10625661 1 25 12 -ABL1 Abl EC 2.7.10.2; KINASE; Kinase, protein; Oncoprotein; Protein kinase, TK; Protein kinase, tyrosine (non-receptor) P00519 25 9q34.12 human S618-p 1779804 APTPPKRsSSFREMD molecular association, regulation; phosphorylation; enzymatic activity, induced Abi-2(DISRUPTS) 18161990 1 2 0 interaction in vitro and in vivo; phosphorylation of this site enhances the association and phosphorylation of the Abl substrate, Crk. -Nr2c2 NR2C2 DNA-binding; Nuclear receptor; Transcription factor P49117 22026 6|6 D1 mouse S351-p 7990482 HVISRDQsTPIIEVE intracellular localization transcription, inhibited; signaling pathway regulation 21478464 1 3 0 supress SCD1 gene expression, regulates lipid metabolism through the metformin-AMPK-TR4-SCD1 pathway -C5AR2 C5AR2 GPCR, family 1; Membrane protein, integral; Membrane protein, multi-pass; Receptor, GPCR Q9P296 27202 19q13.32 human S323-p 9819900 GQDESVDsKKSTSHD activity, induced; receptor internalization, altered; intracellular localization 19615750 1 0 0 -Sod2 SOD2 EC 1.15.1.1; Mitochondrial; Oxidoreductase P09671 20656 17 A1|17 8.75 cM mouse K68-ac 461133 NLNATEEkYHEALAK Sod_Fe_N intracellular localization; enzymatic activity, inhibited; protein conformation; enzymatic activity, altered cell cycle regulation; autophagy, induced; cell differentiation, induced; cytoskeletal reorganization 25529796; 25790176; 28369333; 28433661; 28914882; 33680286 23 13 8 mediates pentameric SOD2 deaggregation; regulates meiotic and spindle defects, induces accumulation of reactive oxygen species; induces ROS production, PARK recruitment to mitochondria and mitophagy; increased hyperglycemia-induced renal damage; SIRT3 deacetylating SOD2 at K68 contributes to differentiation -NFKB2 NFkB-p100 DNA-binding; Oncoprotein; Transcription factor Q00653 4791 10q24.32 human S866-p 450166 TAEVKEDsAYGSQSV molecular association, regulation; protein processing IKKA(INDUCES); BTRC(INDUCES) 11239468; 15310758; 22388891 7 1 0 -SMC3 SMC3 Cell cycle regulation; DNA repair, damage Q9UQE7 9126 10q25.2 human K106-ac 461825 RRVIGAKkDQYFLDK SMC_N protein stabilization; molecular association, regulation cell cycle regulation; DNA repair, induced; chromatin organization, altered; cell growth, induced; cytoskeletal reorganization DNA(INDUCES) 18614053; 20501661; 22101327; 22751501; 28847955; 29196537 7 10 173 regulates mitotic chromosome segregation and sister chromatid cohesion, ESCO2 KO has growth defects; Sister chromatid cohesion -MACF1 ACF7 Actin-binding; Cytoskeletal; Motility/polarity/chemotaxis Q9UPN3 23499 1p34.3 human S7310-p 18507009 ADPKKSAsRPGSRAG intracellular localization cell motility, induced; cytoskeletal reorganization 21295697 1 1 0 inhibits localization along microtubules, alters organization of microtubules, regulates skin wound repair, SC migration -Gab2 GAB2 Adaptor/scaffold Q9Z1S8 14389 7|7 E1 mouse S211-p 4825112 TENARSAsFSQGTRQ molecular association, regulation; phosphorylation cell motility, inhibited; signaling pathway regulation SHP-2(DISRUPTS) 23401857; 26060331 3 19 8 inhibits ERK1/2 phosphorylation, modulates Ras/MAPK signaling pathway; enhances insulin-induced Akt signaling; suppresses EGF-induced Akt signaling -Brsk2 BRSK2 EC 2.7.11.1; EC 2.7.11.26; KINASE; Kinase, protein; Protein kinase, CAMK; Protein kinase, Ser/Thr (non-receptor) Q69Z98 75770 7|7 F5 mouse S467-p 4734917 TPNPTPPsSPSVGGV protein stabilization; enzymatic activity, inhibited; phosphorylation 23790753 1 0 2 inhibits axon branching (activated in BRSK2 18A mutant) -SMN1 SMN RNA processing; RNA-binding Q16637 6606 5q13.2 human T25-p 484165 SVLFRRGtGQSDDSD molecular association, regulation; intracellular localization coilin(INDUCES) 24602413 1 40 17 -Tfe3 TFE3 DNA-binding; Oncoprotein; Transcription factor Q64092 209446 X A1.1|X 3.5 cM mouse S565-p 455896 KASSRRSsFSMEEES DUF3371 intracellular localization autophagy, inhibited 30324847 1 19 8 maintains cytoplasmic localization -PKMYT1 Myt1 EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, Other; Protein kinase, Ser/Thr (non-receptor); Protein kinase, dual-specificity (non-receptor) Q99640 9088 16p13.3 human T455-p 11331003 RTVGSTStPRSRCTP molecular association, regulation PIN1(INDUCES) 10504341 1 1 7 -Creb1 CREB iso1 DNA-binding; Transcription factor P15337-1 81646 9q32 rat K91-ac 459097 QTVQSSCkDLKRLFS transcription, inhibited 12595525 1 0 0 modulating CREB-mediated gene expression -FPR2 FPR2 GPCR, family 1; Membrane protein, integral; Membrane protein, multi-pass; Motility/polarity/chemotaxis; Receptor, GPCR P25090 2358 19q13.41 human T332-p 19075300 LSEDSAPtNDTAANS receptor desensitization, induced; phosphorylation 21543323 1 0 0 -Mlxipl ChREBP Transcription factor Q99MZ3 58805 5|5 G2 mouse T517-gl 89115103 GQKASPPtLASATAS transcription, induced 28450420 1 0 0 S514 phosphorylation could enhance ChREBP O-GlcNAcylation -NFE2 NF-E2 Cytoskeletal; DNA-binding; Transcription factor Q16621 4778 12q13.13 human S157-p 11489902 LNYSDAEsLELEGTE protein degradation; ubiquitination transcription, inhibited 19966288 1 1 0 -Rasgrf1 RASGRF1 GEF; GEF, Ras P28818 192213 8q31 rat S854-p 18710204 FPLFNYNsGIMMTCR protein degradation 21382555 1 1 0 -TCAP Telethonin Motility/polarity/chemotaxis O15273 8557 17q12 human S161-p 3893741 RSLSRSMsQEAQRG_ Telethonin protein degradation; ubiquitination cytoskeletal reorganization 24280220; 32937135 3 8 3 affects synchronous release and removal of Ca2 as a consequence of altered t-tubule organization -PDGFRA PDGFRA EC 2.7.10.1; KINASE; Kinase, protein; Membrane protein, integral; Oncoprotein; Protein kinase, TK; Protein kinase, tyrosine (receptor) P16234 5156 4q12 human Y574-p 448438 PDGHEYIyVDPMQLP molecular association, regulation Src(INDUCES) 9454734 2 3 15 -Kcnj1 ROMK iso2 Channel, potassium; Membrane protein, integral; Membrane protein, multi-pass P35560-2 rat S25-p 449605 RQRARLVsKEGRCNI IRK activity, induced 8621594 9 0 0 phosphorylation of at least two serines necessary for channel activity -FOXG1 FOXG1 DNA-binding; Nuclear receptor co-regulator; Transcription factor P55316 2290 14q12 human S19-p 482880 MIPKSSFsINSLVPE intracellular localization cell differentiation, altered 17435750 1 0 0 -CETN1 CETN1 Q12798 1068 18p11.32 human S170-p 1430241100 LRIMKKTsLY_____ molecular association, regulation; protein conformation SFI1(DISRUPTS) 30682474 1 0 0 -EEF1A1 EEF1A1 Nucleolus; Translation; Translation elongation P68104 1915 6q13 human K165-m3 15382301 TEPPYSQkRYEEIVK GTP_EFTU molecular association, regulation translation, altered EEF1D(DISRUPTS); eEF1B(DISRUPTS); EEF1G(DISRUPTS) 28108655 1 3 3 -PDGFRB PDGFRB EC 2.7.10.1; KINASE; Kinase, protein; Membrane protein, integral; Oncoprotein; Protein kinase, TK; Protein kinase, tyrosine (receptor) P09619 5159 5q32 human S1104-p 454229 PRAEAEDsFL_____ molecular association, regulation; receptor desensitization, altered NHERF(DISRUPTS) 15271984 1 0 0 -PIN1 PIN1 EC 5.2.1.8; Isomerase; Nuclear receptor co-regulator Q13526 5300 19p13.2 human K63-sm 31094509 RCSHLLVkHSQSRRP Rotamase protein degradation; enzymatic activity, inhibited carcinogenesis, inhibited; cell growth, inhibited; transcription, inhibited 23633483 1 0 0 inhibits cyclin D1 stability -TACSTD2 TACSTD2 Membrane protein, integral; Receptor, misc. P09758 4070 1p32.1 human S303-p 451171 VITNRRKsGKYKKVE protein conformation; phosphorylation carcinogenesis, induced; cell growth, induced; cytoskeletal reorganization 25981199; 35132180 2 1 0 -EGFR EGFR EC 2.7.10.1; KINASE; Kinase, protein; Membrane protein, integral; Oncoprotein; Protein kinase, TK; Protein kinase, tyrosine (receptor) P00533 1956 7p11.2 human Y1069-p 448056 EDSFLQRySSDPTGA activity, induced; protein degradation; molecular association, regulation; ubiquitination carcinogenesis, induced; carcinogenesis, inhibited; cell motility, induced CBL(INDUCES) 12631709; 14627991; 16729043; 20215522; 21787862; 33657368; 35197444; 37085908 45 18 117 -Parp2 PARP2 DNA repair, damage; EC 2.4.2.30; Transferase O88554 11546 14 26.25 cM|14 C1 mouse K36-ac 2459112 EDDSPPGkKMRTCQR molecular association, regulation; intracellular localization; enzymatic activity, inhibited DNA(DISRUPTS) 18436469 1 0 3 -Rps6kb1 p70S6K EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, AGC; Protein kinase, Ser/Thr (non-receptor); Translation P67999 83840 10q26 rat S452-p 471897 PVSPVKFsPGDFWGR enzymatic activity, induced 11705993 2 23 76 Quadruple mutant was 20% protected from inactivation by glucocorticoids. -INPPL1 SHIP-2 Carbohydrate Metabolism - inositol phosphate; EC 3.1.3.86; Motility/polarity/chemotaxis; Phosphatase, lipid O15357 3636 11q13.4 human T958-p 475076 APREEPLtPRLKPEG phosphorylation 17219406 1 4 12 Tyrosine phosphorylation is regulated by T958. -Syngap1 SynGAP iso3 GAP; GAP, Ras Q9QUH6-3 192117 20p12 rat S777-p 18710208 EPEQKMLsVNKSVSM DUF3498 molecular association, regulation; intracellular localization HRas(INDUCES) 21382555 1 2 0 -VAMP8 VAMP8 Membrane protein, integral; Vesicle Q9BV40 8673 2p11.2 human T48-p 472548 LEHLRNKtEDLEATS Synaptobrevin activity, inhibited 27402227 1 9 39 abolish function in SNARE complex during mast cell secretion, reduces in vitro ensemble vesicle fusion -BACH2 BACH2 DNA-binding; Transcription factor Q9BYV9 60468 6q15 human S521-p 470117 ETRTRTSsSCSSYSY intracellular localization apoptosis, inhibited; transcription, altered; cell growth, altered 17018862 2 1 0 regulates transcription of HO-1 -DCBLD2 DCBLD2 Cell adhesion; Membrane protein, integral Q96PD2 131566 3q12.1|3 human Y750-p 454600 PAPDELVyQVPQSTQ molecular association, regulation CRKL(INDUCES) 23770091 2 22 204 -LTA4H LTA4H EC 3.3.2.6; Hydrolase; Lipid Metabolism - arachidonic acid P09960 4048 12q23.1 human S416-p 451021 KAYVEKFsYKSITTD Peptidase_M1 enzymatic activity, inhibited 9395533 1 0 0 This phosphorylation and consequent enzymatic activity inhibition have not been observed in lung carcinoma cell line -FLT3 FLT3 EC 2.7.10.1; KINASE; Kinase, protein; Membrane protein, integral; Oncoprotein; Protein kinase, TK; Protein kinase, tyrosine (receptor) P36888 2322 13q12.2 human Y955-p 454873 ADAEEAMyQNVDGRV molecular association, regulation; phosphorylation cell cycle regulation GRB2(INDUCES); Fyn(INDUCES) 16627759; 19438505; 26848862 5 1 15 regulates cell proliferation -Pde4d PDE4D iso6 EC 3.1.4.53; Nucleotide Metabolism - purine; Phosphodiesterase P14270-6 24627 rat S245-p 469621 KKLMHSSsLTNSCIP cell cycle regulation 24815749 2 12 6 -SRSF1 SF2 RNA splicing; RNA-binding; Spliceosome Q07955 6426 17q22 human Y19-p 474154 GNNDCRIyVGNLPPD RRM_1 intracellular localization cell cycle regulation; carcinogenesis, induced; cell growth, induced 30320932 1 2 1 promotes cell proliferation, enhance cell cycle progression -ANTXR2 ANTXR2 Membrane protein, integral; Receptor, misc. P58335 118429 4q21.21 human Y445-p 13320001 QPPQTKWyTPIKGRL Ant_C ubiquitination 20080640 1 0 0 -AHR AHR DNA-binding; Transcription factor P35869 196 7p21.1 human S723-p 1874101928 ELDYPMGsFEPSPYP protein degradation; ubiquitination autophagy, induced; transcription, induced 34198826 1 0 0 -APP APP Apoptosis; Cell surface; Membrane protein, integral; Receptor, misc.; Transcription factor P05067 351 21q21.3 human K132-ac 1880082601 DALLVPDkCKFLHQE intracellular localization 35830807 1 1 0 AK7 ameliorates cognitive deficits in APP/PS1 mice via inhibition of K132/134 acetylation; APP acetylation is neuroprotective in cultured hippocampal neurons; APP localization at the cell surface -CHEK2 Chk2 EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, CAMK; Protein kinase, Ser/Thr (non-receptor); Tumor suppressor O96017 11200 22q12.1 human T517-p 981403 QVLAQPStSRKRPRE intracellular localization 17698850 1 1 0 found in nucleus and chromatin upon exposure with Tax -Erbb3 HER3 EC 2.7.10.1; KINASE; Kinase, protein; Membrane protein, integral; Oncoprotein; Protein kinase, TK; Protein kinase, tyrosine (receptor) Q62799 29496 7q11 rat Y1194-p 448640 EEDEDEEyEYMNRKR molecular association, regulation; phosphorylation PIK3CB(INDUCES); PIK3R1(INDUCES) 11546794 7 3 24 induces phosphorylation of Akt1. -NEK2 NEK2 EC 2.7.11.1; KINASE; Kinase, protein; Nucleolus; Protein kinase, Other; Protein kinase, Ser/Thr (non-receptor) P51955 4751 1q32.3 human S241-p 12574600 RRIPYRYsDELNEII Pkinase enzymatic activity, inhibited 17197699 1 1 0 -Ctnnd2 CTNND2 Actin-binding; Motility/polarity/chemotaxis O35927 18163 15|15 B2 mouse T454-p 480958 TGTFRTStAPSSPGV molecular association, regulation cytoskeletal reorganization RGNEF(INDUCES) 17993462 2 2 0 regulates dendrite formation in hippocampal neurons; interaction with CTNND2 prevents RGNEF from interacting with and activating RhoA. -PIK3C3 PIK3C3 Autophagy; Carbohydrate Metabolism - inositol phosphate; EC 2.7.1.137; Kinase, lipid; Motility/polarity/chemotaxis Q8NEB9 5289 18q12.3 human K771-ac 280006400 YILGRDPkPLPPPMK PI3_PI4_kinase enzymatic activity, inhibited autophagy, inhibited 28844862 1 1 0 nutrient starvation-induced autophagy -Mrtfa MKL1 Oncoprotein; Transcription, coactivator/corepressor Q8K4J6 223701 15|15 E1 mouse S492-p 467355 TGSTPPVsPTPSERS transcription, induced 33171330 3 44 15 regulates the expression of IL-6; regulates re-endothelialization -DBI DBI Lipid-binding P07108 1622 2q14.2 human S21-p 1880114700 RHLKTKPsDEEMLFI molecular association, regulation autophagy, induced Other(DISRUPTS) 36280213 1 0 0 inhibits binding to phosphatidylethanolamine -PACSIN1 PACSIN1 Adaptor/scaffold Q9BY11 29993 6p21.31 human S346-p 4730476 SQAGDRGsVSSYDRG molecular association, regulation PICK1(DISRUPTS) 23918399 2 3 0 regulates AMPAR trafficking -LASP1 Lasp-1 Actin-binding; Motility/polarity/chemotaxis O77506 100009568 rabbit S146-p 448836 AEPERRDsQDSSNYR intracellular localization cytoskeletal reorganization 12432067 6 33 135 -Oprm1 MOR-1 GPCR, family 1; Membrane protein, integral; Membrane protein, multi-pass; Receptor, GPCR P33535 25601 1q11 rat T180-p 448127 VKALDFRtPRNAKIV 7tm_1 receptor desensitization, altered MOR-1(NOT_REPORTED) 11060299; 14978231 3 0 0 Mutagenesis indicates T180 is required for receptor uncoupling, but phosphorylation of site has not been directly demonstrated. -LTB4R LTB4R GPCR, family 1; Membrane protein, integral; Membrane protein, multi-pass; Receptor, GPCR Q15722 1241 14q12 human S313-p 25608200 EGTGSEAsSTRRGGS receptor internalization, induced; phosphorylation signaling pathway regulation 22707565; 30131369 2 0 0 phosphorylation of LTB4R basal phosphorylation site; enhanced ligand-induced internalization ; chemotaxis, B-hexisaminidase release, regulates LTB4R function -RCC1 RCC1 Cell cycle regulation; GEF; GEF, Ras P18754 1104 1p35.3 human T32-p 2850001 VSHRSHStEPGLVLT molecular association, regulation KPNA4(DISRUPTS) 18568422 1 0 0 -MAPK3 ERK1 EC 2.7.11.24; KINASE; Kinase, protein; Protein kinase, CMGC; Protein kinase, Ser/Thr (non-receptor) P27361 5595 16p11.2 human K302-m3 52477002 LFPKSDSkALDLLDR Pkinase enzymatic activity, induced transcription, induced 26586479 1 1 0 SUV420H1 siRNA inhibits ERK expression -CHCHD3 CHCHD3 Mitochondrial Q9NX63 54927 7q32.3-q33 human T11-p 4038300 TTSTRRVtFEADENE intracellular localization 27153535 2 1 0 Parkin recruitment to mitochondria was negatively regulated by PKA-mediated phosphorylation of S528 of MIC60 and T11 of MIC19 -EIF2B5 eIF2B-epsilon Translation; Translation initiation Q13144 8893 3q27.1 human S544-p 449906 EPDSRGGsPQMDDIK signaling pathway regulation; translation, inhibited 22231169 5 77 9 -RBX1 RBX1 EC 6.3.2.-; Ligase; UBIQUITIN LIGASE; Ubiquitin conjugating system; Ubiquitin ligase P62877 9978 22q13.2 human Y106-p 25180501 REWEFQKyGH_____ intracellular localization 22448038 1 0 0 -Prkcb PKCB EC 2.7.11.13; KINASE; Kinase, protein; Motility/polarity/chemotaxis; Protein kinase, AGC; Protein kinase, Ser/Thr (non-receptor) P68403 25023 1q36 rat T642-p 447897 TRQPVELtPTDKLFI Pkinase_C intracellular localization; protein conformation; enzymatic activity, induced transcription, altered 21215369; 8034726; 8327493 14 14 0 increases expression of c-Fos and c-Jun -SOD1 SOD1 Apoptosis; EC 1.15.1.1; Mitochondrial; Nuclear receptor co-regulator; Oxidoreductase P00441 6647 21q22.11 human K76-sm 9184300 SRKHGGPkDEERHVG Sod_Cu protein stabilization 16828461 1 0 0 induces SOD1 aggregation -SHARPIN SHARPIN Apoptosis Q9H0F6 81858 8q24.3 human S146-p 31883820 ACPVSLPsPPEASTL molecular association, regulation carcinogenesis, induced; cell motility, induced ARP2(INDUCES) 36148554 1 4 0 -GABBR1 GABBR1 GPCR, family 3; Membrane protein, integral; Membrane protein, multi-pass; Receptor, GPCR Q9UBS5 2550 6p22.1 human K893-ub 7251351 EKSRLLEkENRELEK protein degradation; ubiquitination 26817839 2 1 2 -CLEC12B CLEC12B Membrane protein, integral; Receptor, misc. Q2HXU8 387837 12p13.2 human Y7-p 12518700 _MSEEVTyATLTFQD molecular association, regulation; activity, inhibited SHP-2(INDUCES); SHP-1(INDUCES) 17562706 1 0 0 inhibition of NK cell cytotoxicity -DAB2 DAB2 Adaptor/scaffold; Tumor suppressor P98082 1601 5p13.1 human S24-p 451211 QAAPKAPsKKEKKKG molecular association, regulation; intracellular localization transcription, altered ITGB3(INDUCES) 10542228; 15280374 4 3 0 N terminius of DAB2 negatively regulated TPA-induced AP-1 activity. -Tp53 p53 Activator; DNA-binding; Motility/polarity/chemotaxis; Nuclear receptor co-regulator; Transcription factor; Tumor suppressor P02340 22059 11 B3|11 42.83 cM mouse S375-p 447534 TKKGQSTsRHKKTMV acetylation 15794754 15 2 0 S375A (S378 in human) mutant stimulates p53 acetylation at K370 (K373 in human); S375D mutant (S378 in human) abrogates constitutive acetylation of p53 at K379 (K382 in human) and does not have any effect on acetylation of K370 (K373 in human) -Rps19 RPS19 Ribosomal; Translation P17074 rat S59-p 7113803 WFYTRAAsTARHLYL Ribosomal_S19e molecular association, regulation RPS19BP1(INDUCES) 19200342 1 0 0 -PRKCB PKCB iso2 EC 2.7.11.13; KINASE; Kinase, protein; Motility/polarity/chemotaxis; Protein kinase, AGC; Protein kinase, Ser/Thr (non-receptor) P05771-2 5579 16p12.2-p12.1 human S660-p 1869073011 QSEFEGFsFVNSEFL Pkinase_C intracellular localization; enzymatic activity, induced 10828076; 24236208 14 34 140 -HES1 HES1 Cell development/differentiation; Motility/polarity/chemotaxis; Transcription factor Q14469 3280 3q29 human S37-p 11424700 TASEHRKsSKPIMEK HLH molecular association, regulation cytoskeletal reorganization; transcription, altered DNA(DISRUPTS) 9389649 1 0 0 in vivo neurite outgrowth -FLT3 FLT3 EC 2.7.10.1; KINASE; Kinase, protein; Membrane protein, integral; Oncoprotein; Protein kinase, TK; Protein kinase, tyrosine (receptor) P36888 2322 13q12.2 human Y726-p 448644 KEHNFSFyPTFQSHP PK_Tyr_Ser-Thr phosphorylation 16627759 2 2 5 While none of the single mutations affected STAT-5 phosphotyrosine levels, 3 double mutations did: Y591/726F, Y591/955F, Y589/591F (all three pairs have Y591F in common). -Gne GNE Carbohydrate Metabolism - amino sugar and nucleotide sugar; Cell adhesion; Cytoskeletal; EC 2.7.1.60; EC 3.2.1.183; Isomerase; Kinase, other; Motility/polarity/chemotaxis O35826 114711 5q22 rat M712-p 21335600 ALLGAASmVLDYTTR ROK intracellular localization 21873062 1 0 0 M71YT mutation in insoluble fraction vs cytosolic for WT GNE -INPPL1 SHIP-2 Carbohydrate Metabolism - inositol phosphate; EC 3.1.3.86; Motility/polarity/chemotaxis; Phosphatase, lipid O15357 3636 11q13.4 human S132-p 468749 PPDDRDAsDGEDEKP protein degradation; intracellular localization; protein conformation; enzymatic activity, induced cytoskeletal reorganization 21770892; 23040614 2 33 0 -RPS6KB1 p70S6K EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, AGC; Protein kinase, Ser/Thr (non-receptor); Translation P23443 6198 17q23.1 human S447-p 448357 GSPRTPVsPVKFSPG activity, induced; molecular association, regulation; enzymatic activity, induced cell cycle regulation; cell adhesion, altered Tau iso8(NOT_REPORTED) 12759354; 15028555; 15051500; 15304500; 16364302; 35077510; 7545671 102 54 247 -MAPK6 ERK3 EC 2.7.11.24; KINASE; Kinase, protein; Protein kinase, CMGC; Protein kinase, Ser/Thr (non-receptor) Q16659 5597 15q21.2 human S688-p 13830503 QFHSPVGsPLKSIQA protein stabilization 20236090 1 9 8 -Mapk13 P38D EC 2.7.11.24; KINASE; Kinase, protein; Protein kinase, CMGC; Protein kinase, Ser/Thr (non-receptor) Q9Z1B7 26415 17|17 A3.3 mouse Y182-p 454935 TDTEMTGyVVTRWYR Pkinase enzymatic activity, induced 10066767; 9374491 4 22 997 -HOXB7 HOXB7 DNA-binding; Motility/polarity/chemotaxis; Transcription factor P09629 3217 17q21.32 human S133-p 465570 IYPWMRSsGTDRKRG cell differentiation, altered 11290787 1 0 0 -H3-4 HIST3H3 DNA-binding Q16695 8290 1q42.13 human K79-m2 14990400 REIAQDFkTDLRFQS Histone molecular association, regulation L3MBTL iso4(INDUCES) 23583077 0 3 1 -PTK2 FAK EC 2.7.10.2; KINASE; Kinase, protein; Protein kinase, TK; Protein kinase, tyrosine (non-receptor) Q05397 5747 8q24.3 human T474-p 60179302 KFLQEALtMRQFDHP PK_Tyr_Ser-Thr enzymatic activity, inhibited; protein conformation 27790061 1 0 0 T474 phosphorylation recruits SHP-2 to decrease FAK activity, FERM-mediated autoinhibition -DUOX1 DUOX1 EC 1.6.3.1; Membrane protein, integral; Membrane protein, multi-pass; Oxidoreductase Q9NRD9 53905 15q21.1 human S955-p 6370301 KDLCRRAsYISQDMI enzymatic activity, induced 19144650 1 3 0 -NOS1 nNOS Amino Acid Metabolism - arginine and proline; EC 1.14.13.39; Oxidoreductase P29475 4842 12q24.22 human Y609-p 465469 DYCDNSRyNILEEVA NO_synthase molecular association, regulation; enzymatic activity, inhibited Src(INDUCES) 16690617 1 0 0 prevents homodimerization -Anxa7 ANXA7 Calcium-binding; Lipid-binding; Motility/polarity/chemotaxis Q6IRJ7 155423 15p16 rat T261-p 18908667 VLIEILCtRTNQEIR Annexin molecular association, regulation SNAP23(INDUCES); SNAP-25(INDUCES) 29196215 3 1 0 -COIL coilin Oxidoreductase P38432 8161 17q22 human S184-p 11329300 NEEAKRKsPKKKEKC Coilin_N intracellular localization 11102515 3 2 0 S184A mutant localized to nucleolus -HMGN2 HMGN2 DNA-binding P05204 3151 1p36.11 human K36-sm 33622400 SAKPAPPkPEPKPKK HMG14_17 protein stabilization; molecular association, regulation chromatin organization, altered; transcription, induced DNA(DISRUPTS) 24872413 1 1 0 -TOB1 TOB1 Adaptor/scaffold; Cell cycle regulation P50616 10140 17q21.33 human S154-p 455536 SSVSSSPsPPFGHSA activity, inhibited cell cycle regulation; cell growth, inhibited; cell growth, altered 12050114; 12151396; 22252318 3 0 0 promote mRNA deadenylaion and decay and the ability to suppress proliferation; the antiproliferative activity of TOB1 is inhibited by phosphorylation.; the antiproliferative function of TOB1 is inhibited by phosphorylation. -FOXL2 FOXL2 DNA-binding; Transcription factor P58012 668 3q22.3 human S326-p 21697905 PGQLSPAsPATAAPP intracellular localization 22022399 1 1 0 -CTNND1 CTNND1 Actin-binding; Adaptor/scaffold; Cell adhesion; G protein regulator, misc.; Motility/polarity/chemotaxis O60716 1500 11q12.1 human S252-p 450456 MEGYRAPsRQDVYGP carcinogenesis, induced; cell motility, induced; cell adhesion, inhibited 32589661 6 54 205 -SSRP1 SSRP1 Nucleolus; RNA-binding; Transcription initiation complex; Transcription, coactivator/corepressor Q08945 6749 11q12.1 human S510-p 455268 SSSNEGDsDRDEKKR activity, inhibited transcription, altered 15659405 1 0 0 -PPP1R3F PPP1R3F Membrane protein, integral; Protein phosphatase, regulatory subunit Q6ZSY5 89801 Xp11.23 human S14-p 22497901 VEPPLRHsAPPSPAA signaling pathway regulation 21668450 1 5 0 regulation of glycogen synthesis via R3F-PP1 signaling in astrocytoma cells -Camk2b CAMK2B EC 2.7.11.17; KINASE; Kinase, protein; Protein kinase, CAMK; Protein kinase, Ser/Thr (non-receptor) P28652 12323 11 A1|11 3.89 cM mouse T311-p 15719513 ILTTMLAtRNFSVGR enzymatic activity, inhibited 36194579 2 5 2 -SORBS2 ArgBP2 iso2 Adaptor/scaffold; Motility/polarity/chemotaxis O94875-2 8470 4q35.1 human Y59-p 31834901 RPFSPSAySLPASLN protein conformation 24475245 1 0 0 reduced self-interaction -SLC12A3 NCCT Membrane protein, integral; Membrane protein, multi-pass; Transporter; Transporter, SLC family P55017 6559 16q13 human K706-ub 27200726 WLNKRKIkAFYSDVI SLC12 protein degradation; ubiquitination; activity, inhibited; phosphorylation endocytosis, induced 29021560 1 1 0 NCC transport activity decreased. phosphorylation inhibited -Ptpa PPP2R4 EC 5.2.1.8; Motility/polarity/chemotaxis; Protein phosphatase, regulatory subunit P58389 110854 2 B|2 21.71 cM mouse K28-ub 964537436 QNFIIPKkEIHTVPD PTPA protein degradation; ubiquitination; methylation cytoskeletal reorganization 31160454 1 2 0 mediating the effects of UBE3A on spine morphology. -Hist1h2ail1 H3 DNA-binding Q6LED0 291159 17p11 rat K14-ac 458954 ARKSTGGkAPRKQLA Histone molecular association, regulation chromatin organization, altered; transcription, induced; transcription, altered DNA(INDUCES) 17495236; 17628002; 17880897; 19476549; 19909801 162 31 355 -ETV1 ETV1 DNA-binding; Oncoprotein; Transcription factor P50549 2115 7p21.2 human S216-p 3059600 PMYQRQMsEPNIPFP ETS_PEA3_N activity, induced; protein stabilization; molecular association, regulation carcinogenesis, induced; cell motility, induced; transcription, induced 14-3-3 theta(INDUCES); 14-3-3 epsilon(INDUCES) 12213813; 23774214 3 3 2 MMP-1 transcription -UGT2B7 UGT2B7 Carbohydrate Metabolism - ascorbate and aldarate; Carbohydrate Metabolism - pentose and glucuronate interconversions; Carbohydrate Metabolism - starch and sucrose; Cofactor and Vitamin Metabolism - porphyrin and chlorophyll; Cofactor and Vitamin Metabolism - retinol; EC 2.4.1.17; Lipid Metabolism - androgen and estrogen; Membrane protein, integral; Transferase; Xenobiotic Metabolism - drug metabolism - cytochrome P450; Xenobiotic Metabolism - drug metabolism - other enzymes; Xenobiotic Metabolism - metabolism by cytochrome P450 P16662 7364 4q13.2 human Y438-p 7378201 RVINDPSyKENVMKL UDPGT enzymatic activity, induced 19289110; 21056984 2 1 0 -GAPDH GAPDH Carbohydrate Metabolism - glycolysis and gluconeogenesis; EC 1.2.1.12; Oxidoreductase P04406 2597 12p13.31 human Y94-p 25293196 WGDAGAEyVVESTGV Gp_dh_N enzymatic activity, induced 26629320 1 3 1 -Irak1bp1 IRAK1BP1 Transcription regulation Q9ESJ7 65099 9|9 E2 mouse S234-p 12524610 TVQQKIKsATIHAAS SIMPL intracellular localization transcription, altered 17079333 1 0 1 nuclear localization -IRAK1 IRAK1 EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, Ser/Thr (non-receptor); Protein kinase, TKL P51617 3654 Xq28 human T100-p 447720 LRARDIItAWHPPAP Death transcription, inhibited 11976320 1 0 0 -Gli2 GLI2 C2H2-type zinc finger protein; Oncoprotein; Transcription factor Q0VGT2 14633 1 E2.3|1 52.17 cM mouse R227-me 1877628102 TPRLSRKrALSISPL molecular association, regulation signaling pathway regulation SUFU(DISRUPTS) 31000813 1 0 0 increases Shh signaling leading to prevention of cellular senescence -Rorc RORC iso2 DNA-binding; Nuclear receptor; Transcription factor P51450-2 19885 3|3 F2.1 mouse S376-p 139835702 GCSELISsIFDFSHF Hormone_recep cell differentiation, induced; transcription, induced 28667162 1 1 0 -CELF1 CELF1 Cell development/differentiation; RNA processing; RNA-binding Q92879 10658 11p11.2 human S179-p 29668003 QTMEGCSsPMVVKFA RNA splicing, altered 24151077 1 3 0 splicing regulation in diabetes -CEP250 CEP250 Cell cycle regulation Q9BV73 11190 20q11.22 human S2417-p 20831304 ETRRLDEsLTQSLTS intracellular localization cell cycle regulation 21723128; 25660448 3 2 1 -Star STAR Carrier; Lipid-binding; Mitochondrial P70114 101844174 hamster S55-p 450439 ISQVRRRsSLLGSQL enzymatic activity, induced 15336703 3 1 0 -Map2 MAP2 iso3 Cytoskeletal; Motility/polarity/chemotaxis P15146-3 25595 9q32 rat K324-ac 62495506 IGSTDNIkYQPKGGQ Tubulin-binding cytoskeletal reorganization 28002468 1 1 0 -ACACA ACC1 Carbohydrate Metabolism - propanoate; Carbohydrate Metabolism - pyruvate; EC 6.3.4.14; EC 6.4.1.2; Ligase; Lipid Metabolism - fatty acid biosynthesis Q13085 31 17q12 human S80-p 448292 LHIRSSMsGLHLVKQ enzymatic activity, inhibited; intracellular localization; protein conformation carcinogenesis, altered; autophagy, induced; apoptosis, induced; cell growth, inhibited; apoptosis, inhibited 21918180; 28778925; 29899443; 30309849; 34362796; 34418433; 35761398; 36243112 166 76 11 -Prkd1 PRKD1 Autophagy; EC 2.7.11.13; KINASE; Kinase, protein; Motility/polarity/chemotaxis; Protein kinase, CAMK; Protein kinase, Ser/Thr (non-receptor) Q62101 18760 12|12 B3 mouse S403-p 4169976 EDSNRTIsPSTSNNI enzymatic activity, inhibited 19135240 1 36 3 in vitro -RIMS1 RIMS1 Adaptor/scaffold; Vesicle Q86UR5 22999 6q13 human K488-sm 31089520 AVLMRKAkREKVETM molecular association, regulation neural plasticity; exocytosis, induced CACNA1A(INDUCES) 24290762 1 0 0 -CRMP1 CRMP-1 Cell development/differentiation; Cytoskeletal; Hydrolase Q14194 1400 4p16.2 human T102-p 11539301 AALVGGTtMIIDHVV Amidohydro_1 cell cycle regulation 19799413 1 1 0 -Gab2 GAB2 Adaptor/scaffold Q9Z1S8 14389 7|7 E1 mouse S612-p 454021 ALDFQPGsPSPHRKP molecular association, regulation PIK3R1(DISRUPTS) 28096188 2 6 14 -PTOV1 PTOV1 Q86YD1 53635 19q13.33 human S36-p 11138413 VRAVRSRsWPASPRG protein stabilization; molecular association, regulation; intracellular localization 14-3-3 zeta(INDUCES); HUWE1(DISRUPTS) 34654719 1 19 6 -PANK4 PANK4 Cofactor and Vitamin Metabolism - pantothenate and CoA biosynthesis; EC 2.7.1.33; Kinase, other Q9NVE7 55229 1p36.32 human T406-p 478688 AQRARSGtFDLLEMD enzymatic activity, inhibited cell growth, induced 35896750 1 15 58 inhibits ACLY activity -LMNA lamin A/C Cytoskeletal P02545 4000 1q22 human S628-p 483561 TVTRSYRsVGGSGGG molecular association, regulation; intracellular localization 24741066 1 37 8 regulate assembly of lamin A -STK11 LKB1 Autophagy; EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, CAMK; Protein kinase, Ser/Thr (non-receptor); Tumor suppressor Q15831 6794 19p13.3 human K97-ac 3173802 NGEANVKkEIQLLRR Pkinase enzymatic activity, inhibited Other(INDUCES) 23086944 1 1 0 -LDHB LDH-B Amino Acid Metabolism - cysteine and methionine; Carbohydrate Metabolism - glycolysis and gluconeogenesis; Carbohydrate Metabolism - propanoate; Carbohydrate Metabolism - pyruvate; EC 1.1.1.27; Oxidoreductase P07195 3945 12p12.1 human S162-p 31882222 PKHRVIGsGCNLDSA enzymatic activity, induced cell cycle regulation; carcinogenesis, induced; cell growth, induced 31804482 1 3 0 promotes glycolysis -PTPN1 PTP1B EC 3.1.3.48; Motility/polarity/chemotaxis; PHOSPHATASE; Phosphatase; Protein phosphatase, tyrosine (non-receptor) P18031 5770 20q13.13 human K335-sm 12004414 FPNHQWVkEETQEDK enzymatic activity, inhibited signaling pathway regulation 17159996 1 0 0 insulin signaling -MAPK6 ERK3 EC 2.7.11.24; KINASE; Kinase, protein; Protein kinase, CMGC; Protein kinase, Ser/Thr (non-receptor) Q16659 5597 15q21.2 human S684-p 13830500 IGIPQFHsPVGSPLK protein stabilization 20236090 1 10 10 -MISP MISP Unknown function Q8IVT2 126353 19p13.3 human S471-p 457012 TMSPRHLsESSGKPL AKAP2_C molecular association, regulation ACTA1(DISRUPTS) 34023777 1 19 0 -Dok7 DOK7 Activator; Adaptor/scaffold Q18PE0 231134 5|5 B2 mouse Y406-p 17535700 PTSLRHHyDTPRSLR molecular association, regulation; phosphorylation MUSK(INDUCES); NCK1(INDUCES); CRKL(INDUCES); NCK2(INDUCES); CRK(INDUCES) 21041412 2 1 3 plays an important role in AChR clustering; stimulates MuSK and AChR phosphorylation -Src Src iso1 EC 2.7.10.2; KINASE; Kinase, protein; Oncoprotein; Protein kinase, TK; Protein kinase, tyrosine (non-receptor) P05480-1 20779 2 H1|2 78.35 cM mouse Y424-p 448234 RLIEDNEyTARQGAK PK_Tyr_Ser-Thr activity, induced; molecular association, regulation; phosphorylation; enzymatic activity, induced cell differentiation, altered; cytoskeletal reorganization GRB2(INDUCES) 11713208; 14739300; 20228840; 2460746; 30622194; 33203880 447 103 3046 represses osteoblast differentiation; required for normal organization of actin cytoskeleton and for bone resorption. -CEACAM1 CEACAM1 Cell adhesion; Immunoglobulin superfamily; Membrane protein, integral; Motility/polarity/chemotaxis P13688 634 19q13.2 human S461-p 6311908 FGKTGRAsDQRDLTE activity, inhibited apoptosis, altered 19146852 2 1 0 blocks formation of lumen -UBE2I UBC9 EC 6.3.2.-; EC 6.3.2.19; Ligase; Nuclear receptor co-regulator; SUMO LIGASE; SUMO conjugating system; SUMO ligase; UBIQUITIN LIGASE; Ubiquitin conjugating system; Ubiquitin ligase P63279 7329 16p13.3 human K65-sm 60338000 FKLRMLFkDDYPSSP UQ_con signaling pathway regulation 27501389 1 1 0 TTR specifically modulates general protein SUMOylation -RPS6KA2 RSK3 EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, AGC; Protein kinase, Ser/Thr (non-receptor); Translation; Tumor suppressor Q15349 6196 6q27 human S218-p 1883400 DHDKRAYsFCGTIEY Pkinase molecular association, regulation; enzymatic activity, induced AKAP6(DISRUPTS) 16337591; 7642538 2 2 4 -Bid BID Apoptosis; Mitochondrial P70444 12122 6 F1|6 57.02 cM mouse S64-p 448405 QTDGSQAsRSFNQGR BID protein stabilization apoptosis, inhibited 11583622 3 0 0 The double mutant S61A/S64A was used in this study -HSD17B13 HSD17B13 EC 1.1.-.-; Oxidoreductase; Secreted; Secreted, signal peptide Q7Z5P4 345275 4q22.1 human S33-p 4765436 FIPQRRKsVAGEIVL molecular association, regulation; enzymatic activity, inhibited; protein conformation PNPLA2(DISRUPTS) 36323699 1 5 0 -Cited1 CITED1 Nuclear receptor co-regulator P97769 12705 X D|X 45.25 cM mouse S64-p 3245861 ANGVPTSsSGSTSPI CITED intracellular localization cell differentiation, induced 23529225 1 0 0 S63/64/65/67/69/73/79/80/84A mutation in CITED1 inhibits its translocation into the nucleus and osteoblasts differentiation -TP53BP1 53BP1 DNA repair, damage; Transcription, coactivator/corepressor Q12888 7158 15q15.3 human S1678-p 476255 ITSEEERsPAKRGRK molecular association, regulation; intracellular localization signaling pathway regulation KPNA1(DISRUPTS); KPNB1(DISRUPTS); KPNA2(DISRUPTS) 29603287; 30685087 4 35 3 -TWIST1 TWIST1 Cell development/differentiation; DNA-binding; Inhibitor; Transcription regulation Q15672 7291 7p21.1 human S42-p 14821304 GGRKRRSsRRSAGGG protein degradation carcinogenesis, induced; apoptosis, altered 20400976; 26759241 5 1 0 -RARA RARA DNA-binding; Nuclear receptor; Oncoprotein; Transcription factor P10276 5914 17q21.2 human S96-p 465508 FVCQDKSsGYHYGVS zf-C4 activity, inhibited transcription, inhibited 16417524 1 0 0 -PIK3R1 PIK3R1 KINASE; Kinase, lipid; Motility/polarity/chemotaxis P27986 5295 5q13.1 human K459-sm 56709102 YNTQFQEkSREYDRL PI3K_P85_iSH2 carcinogenesis, induced; cell motility, induced 26411363 1 0 0 mutant induces phosphorylation and increases cell motility -Kcnj8 KCNJ8 Channel, potassium; Membrane protein, integral; Membrane protein, multi-pass Q63664 25472 4q44 rat S391-p 1458602 NSMRRNNsMRRSNSI activity, inhibited 18048350 1 0 0 -NOS2 iNOS Amino Acid Metabolism - arginine and proline; EC 1.14.13.39; Oxidoreductase P35228 4843 17q11.2 human Y1055-p 4115776 LPGKPKVyVQDILRQ NAD_binding_1 protein stabilization 19875457 1 2 4 -Ncoa3 SRC-3 ACETYLTRANSFERASE; Acetyltransferase; EC 2.3.1.48; Motility/polarity/chemotaxis; Nuclear receptor co-regulator; Transcription, coactivator/corepressor O09000 17979 2|2 H3 mouse S498-p 454109 SPAAGAHsPMGPSGN NCOA_u2 carcinogenesis, inhibited; cell growth, inhibited; cell differentiation, induced; transcription, inhibited; signaling pathway regulation 20534466 7 0 0 inhibits insulin/IGF1 signaling -FUS hnRNP P2 DNA-binding; Nuclear receptor co-regulator; Oncoprotein; RNA splicing; RNA-binding; SUMO LIGASE P35637 2521 16p11.2 human K315-ac 1877549400 IGIIKTNkKTGQPMI RRM_1 molecular association, regulation RNA(DISRUPTS) 32691043 1 1 0 -ESR1 ER-alpha DNA-binding; Nuclear receptor; Transcription factor P03372 2099 6q25.1-q25.2 human S104-p 448099 FPPLNSVsPSPLMLL Oest_recep activity, induced; molecular association, regulation carcinogenesis, induced; cell motility, induced; cell growth, induced; transcription, induced; transcription, altered Src(INDUCES); SRC-2(INDUCES); SRC-3(INDUCES); CBP(INDUCES) DNA(INDUCES) 11108261; 12714702; 16076840; 18372406; 23861392; 25531331; 26522726; 33542078 25 1 0 -TUFM EFTU Mitochondrial; RNA-binding; Translation; Translation elongation P49410 281556 cow Y266-p 464399 LLPVESVySIPGRGT molecular association, regulation translation, inhibited RNA(DISRUPTS) 36379377 1 1 11 -Pcyt2 PCYT2 EC 2.7.7.14; Lipid Metabolism - glycerophospholipid; Transferase Q922E4 68671 11|11 E2 mouse S223-p 31834921 QKIIQFAsGKEPQPG enzymatic activity, induced cell growth, induced 24519946 1 1 0 -RUNX2 AML3 DNA-binding; Transcription factor Q13950 860 6p21.1 human S294-p 10892804 DPRQAQSsPPWSYDQ transcription, induced 19801668 10 2 0 -Psmb6 PSMB6 EC 3.4.25.1; Protease; Proteasome complex Q60692 19175 11 B3|11 42.99 cM mouse S157-p 7320569 GGMMVRQsFAIGGSG Proteasome molecular association, regulation cell growth, inhibited p27Kip1(DISRUPTS) 23725357 1 1 0 Phosphorylation of PSMB6 at S157 inhibits degradation of p27Kip1. -Sirt1 SIRT1 Apoptosis; DEACETYLASE; Deacetylase; EC 3.5.1.-; Nuclear receptor co-regulator Q923E4 93759 10|10 B4 mouse S164-p 6006904 DDRTSHAsSSDWTPR intracellular localization; enzymatic activity, inhibited 28533219 1 4 0 inhibits its nuclear localization, inhibits fatty acid oxidation and promotes fatty liver -YAP1 YAP1 Oncoprotein; Transcription, coactivator/corepressor P46937 10413 11q22.1 human Y391-p 15565111 PFLNSGTyHSRDEST protein degradation; molecular association, regulation; ubiquitination; intracellular localization carcinogenesis, induced; carcinogenesis, inhibited; cell growth, induced; apoptosis, inhibited; transcription, induced SIAH1(INDUCES) 34253611; 35041461; 35723276 6 4 3 -AFP AFP Secreted; Secreted, signal peptide P02771 174 4q13.3 human K242-ac 1879738502 FQAITVTkLSQKFTK ubiquitination carcinogenesis, induced; cell motility, induced; cell growth, induced; apoptosis, inhibited 31811908 1 1 0 inhibits ubiquitination, promotes the migration and invasion -FERMT2 kindlin-2 Cytoskeletal; Motility/polarity/chemotaxis Q96AC1 10979 14q22.1 human K187-ub 1875153100 SSPGLYSkTMTPTYD protein degradation cell adhesion, inhibited 28408404 1 0 0 -CFTR CFTR Channel, chloride; EC 3.6.3.49; Hydrolase; Membrane protein, integral; Membrane protein, multi-pass; Transporter; Transporter, ABC family P13569 1080 7q31.2 human Y512-p 21041602 NIIFGVSyDEYRYRS ABC_tran intracellular localization endocytosis, induced 21807898; 21930781 2 0 0 regulates cell surface expression -PEX5 PEX5 iso3 Membrane protein, integral; Receptor, protein translocating P50542-3 5830 12p13.31 human K464-ub 1873159800 DSLFLEVkELFLAAV protein stabilization 28724525 1 0 0 regulates peroxisomal cargo protein import -Slc6a9 GlyT1 Membrane protein, integral; Membrane protein, multi-pass; Transporter, SLC family P28571 14664 4 D2.1|4 53.62 cM mouse S690-p 30984060 GSSRFQDsRI_____ molecular association, regulation PSD-95(DISRUPTS) 31741150 2 1 0 -Dab1 DAB1 Adaptor/scaffold P97318 13131 4 C6|4 47.79 cM mouse Y200-p 447960 VEDPVYQyIVFEAGH neural plasticity; cell differentiation, induced; cytoskeletal reorganization 14517291; 22586277 5 0 0 alternatively spliced variants -DYRK1B DYRK1B EC 2.7.12.1; KINASE; Kinase, protein; Protein kinase, CMGC; Protein kinase, dual-specificity (non-receptor) Q9Y463 9149 19q13.2 human Y271-p 458096 CQLGQRIyQYIQSRF Pkinase enzymatic activity, induced 10910078; 16257974 2 14 175 -SNCA SNCA Adaptor/scaffold P37840 6622 4q22.1 human K60-ub 1876998401 ATVAEKTkEQVTNVG Synuclein protein degradation; ubiquitination 31167929 1 2 0 ubiquitination and degradation of internalized SNCA fibrils -BLVRA BVR Cofactor and Vitamin Metabolism - porphyrin and chlorophyll; EC 1.3.1.24; KINASE; Kinase, protein; Oxidoreductase; Protein kinase, Ser/Thr (non-receptor) P53004 644 7p13 human S33-p 25526803 DLRNPHPsSAFLNLI GFO_IDH_MocA enzymatic activity, induced 22584576 1 1 0 -GRK1 GRK1 EC 2.7.11.14; KINASE; Kinase, protein; Protein kinase, AGC; Protein kinase, Ser/Thr (non-receptor) P28327 281457 cow S5-p 2528801 ___MDFGsLETVVAN enzymatic activity, induced 18339619 2 1 0 in vitro -Slc5a5 SLC5A5 Membrane protein, integral; Membrane protein, multi-pass; Transporter; Transporter, SLC family Q63008 114613 16p14 rat T577-p 990308 APKEDTAtLEESLVK activity, induced; protein stabilization 17913707 1 1 0 -SMAD7 SMAD7 DNA-binding; Transcription factor O15105 4092 18q21.1 human S206-p 1869370301 SRLCELEsPPPPYSR molecular association, regulation WWP2(INDUCES) 31546607 1 0 0 -PELP1 PELP1 Nuclear receptor co-regulator; Transcription, coactivator/corepressor Q8IZL8 27043 17p13.2 human Y920-p 473548 EEEDEEEyFEEEEEE molecular association, regulation apoptosis, inhibited; cell growth, altered PIK3R1(INDUCES) 17194752 1 0 0 -KPNA2 KPNA2 Karyopherin; Nuclear import; Nucleoporin P52292 3838 17q24.2 human S105-p 454033 QAARKLLsREKQPPI activity, induced; molecular association, regulation; intracellular localization HuR(INDUCES) 15342649; 17919121 3 0 0 regulates HuR nuclear import through S105 phosphorylation and K22 acetylation ; promotes the nuclear localization of HuR -PDE4B PDE4B EC 3.1.4.53; Nucleotide Metabolism - purine; Phosphodiesterase Q07343 5142 1p31.3 human S133-p 449097 GHSQRREsFLYRSDS enzymatic activity, induced 12023945 4 22 1 -HSF1 HSF1 DNA-binding; Transcription factor Q00613 3297 8q24.3 human S230-p 448072 PKYSRQFsLEHVHGS activity, induced; molecular association, regulation; intracellular localization; activity, inhibited carcinogenesis, induced; cell growth, induced; apoptosis, induced; transcription, induced; transcription, inhibited CDK9(INDUCES) DNA(INDUCES) 23587601; 25380824; 25963659; 26361762; 33177089; 35080342 16 2 4 -NDC80 HEC1 Cell cycle regulation O14777 10403 18p11.32 human S75-p 1877641900 NSQLGIFsSSEKIKD Ndc80_HEC cytoskeletal reorganization 35878017 1 1 0 -EGFR EGFR EC 2.7.10.1; KINASE; Kinase, protein; Membrane protein, integral; Oncoprotein; Protein kinase, TK; Protein kinase, tyrosine (receptor) P00533 1956 7p11.2 human Y891-p 36100600 ESILHRIyTHQSDVW PK_Tyr_Ser-Thr molecular association, regulation SH3BGRL3(INDUCES) 16729043 1 0 0 -GPRC5A RAIG1 GPCR, family 3; Membrane protein, integral; Membrane protein, multi-pass; Receptor, GPCR Q8NFJ5 9052 12p13.1 human Y350-p 450339 WPSPYKDyEVKKEGS cell growth, induced 25311788 1 24 803 Tyrosine phosphorylation inhibits the suppressive effect of RAIG1 on cell invasion and anchorage-independent growth. -MAPK8IP1 JIP1 Adaptor/scaffold Q9UQF2 9479 11p11.2 human S421-p 458259 DNCASVSsPYESAIG protein conformation 24914561 3 1 0 promotes anterograde autophagosome transport -ORAI1 ORAI1 Channel, calcium; Membrane protein, integral; Membrane protein, multi-pass Q96D31 84876 12q24.31 human S27-p 469411 GGSTTSGsRRSRRRS activity, induced; molecular association, regulation; intracellular localization; activity, inhibited cell growth, inhibited; cell motility, inhibited IP3R2(INDUCES) 20534587; 23144458; 31652779; 35805121 5 0 0 -ENG ENG Membrane protein, integral; Motility/polarity/chemotaxis; Receptor, misc. P17813 2022 9q34.11 human Y612-p 34729906 LLTAALWyIYSHTRS receptor internalization, induced; protein degradation; intracellular localization cell motility, induced; cell growth, induced 25070888 1 0 0 1)ALK1, TBRII, ENG degradation 2) induces endothelial capillary sprouting and stability, EC functions during angiogenesis -MDM2 MDM2 EC 6.3.2.-; EC 6.3.2.19; Inhibitor; Ligase; NEDDYLATION LIGASE; Neddylation Ligase; Nucleolus; Oncoprotein; UBIQUITIN LIGASE; Ubiquitin conjugating system; Ubiquitin ligase Q00987 4193 12q15 human S157-p 455457 SHLVSRPsTSSRRRA enzymatic activity, induced cell cycle regulation; apoptosis, altered 15688025 1 0 0 increases E3 ligase activity toward p53 and promotes p53 degradation -PTEN PTEN Carbohydrate Metabolism - inositol phosphate; EC 3.1.3.16; EC 3.1.3.48; EC 3.1.3.67; Motility/polarity/chemotaxis; Nuclear receptor co-regulator; PHOSPHATASE; Phosphatase, lipid; Tumor suppressor P60484 5728 10q23.31 human K125-ac 470077 HVAAIHCkAGKGRTG molecular association, regulation; enzymatic activity, inhibited; phosphorylation cell cycle regulation; carcinogenesis, inhibited; signaling pathway regulation MTA1(INDUCES) 16829519; 25447541 2 0 0 decreases p-Akt at S473; regulation of PI3K/AKT pathway, reduced phosphorylation of Akt -TP63 p63 DNA-binding; Transcription factor Q9H3D4 8626 3q28 human S560-p 4668108 LARLGCSsCLDYFTT SAM_2 protein degradation 18769144 1 1 0 -CSF2RB CSF2RB Membrane protein, integral; Receptor, cytokine P32927 1439 22q12.3 human Y822-p 450124 VLQQVGDyCFLPGLG activity, induced apoptosis, altered; transcription, altered; cell growth, altered 10329850; 10672044 2 0 0 -MYC Myc DNA-binding; Nucleolus; Oncoprotein; Transcription factor P01106 4609 8q24.21 human R314-me 1873076612 HSPLVLKrCHVSTHQ Myc_N molecular association, regulation transcription, induced p300(INDUCES); MAX(INDUCES) 28652407 1 1 0 proximity ligation assay (PLA) -H2AC11 H2A.1 DNA-binding P0C0S8 8329 6p22.1 human Y57-p 1874775700 YLAAVLEyLTAEILE Histone carcinogenesis, inhibited; cell growth, inhibited; apoptosis, induced; cell motility, inhibited 34532094 1 0 0 -TERF1 TRF1 DNA-binding P54274 7013 8q21.11 human T122-p 2481000 LTACQLRtIYICQFL TRF protein stabilization; molecular association, regulation; intracellular localization TRF1(INDUCES); CK2B(INDUCES) DNA(INDUCES) 18347021; 24415760 2 0 0 regulates telomere length ; PinX1 stabilizes T122A mutant and allows binding to telomeres. -EPAS1 HIF2A DNA-binding; Transcription factor Q99814 2034 2p21 human K741-ac 7761200 HLMWKRMkNLRGGSC transcription, inhibited 19498162 2 1 0 -Gria1 GluR1 Channel, calcium; Channel, ligand-gated; Membrane protein, integral; Membrane protein, multi-pass P23818 14799 11 B1.3|11 34.51 cM mouse S863-p 448566 TSTLPRNsGAGASGG activity, induced; protein stabilization; receptor desensitization, altered; intracellular localization; receptor internalization, altered; receptor recycling, altered; phosphorylation neural plasticity 12628184; 17689977; 17880895; 17923095; 19892736; 19906877; 21483826; 21738458; 24706758; 33979625; 34642320; 34664085 102 0 0 -Ikzf1 Ikaros C2H2-type zinc finger protein; DNA-binding; Transcription factor Q03267 22778 11 A1|11 7.02 cM mouse K239-sm 3609103 PGVCPVIkEETNHNE molecular association, regulation transcription, induced SIN3A(DISRUPTS); SIN3B(DISRUPTS); CHD-4(DISRUPTS); CTBP1(DISRUPTS) 15767674 2 0 0 -MEF2C MEF2C DNA-binding; Transcription factor Q06413 4208 5q14.3 human S222-p 474086 GYGNPRNsPGLLVSP cell cycle regulation; apoptosis, inhibited; transcription, induced 29431698 1 33 1 AML chemotherapy resistance; required for leukemia maintenance -Nos1 nNOS Amino Acid Metabolism - arginine and proline; EC 1.14.13.39; Oxidoreductase P29476 24598 12q16 rat T1296-p 457129 DHIYREEtLQAKNKG NAD_binding_1 enzymatic activity, inhibited 16214135 1 0 0 -KLF8 KLF8 C2H2-type zinc finger protein; DNA-binding; Transcription factor O95600 11279 Xp11.21 human K67-ac 25344507 PALFNDIkIEPPEEL transcription, inhibited 21416054 1 1 0 -CDC14A CDC14A EC 3.1.3.16; EC 3.1.3.48; Motility/polarity/chemotaxis; PHOSPHATASE; Protein phosphatase, dual-specificity Q9UNH5 8556 1p21.2 human S453-p 1216243801 KTSKMALsPSATAKR molecular association, regulation 30089874 1 1 0 interaction with putative unknown substrates or regulators -CDK9 CDK9 Cell cycle regulation; EC 2.7.11.22; EC 2.7.11.23; KINASE; Kinase, protein; Nuclear receptor co-regulator; Protein kinase, CMGC; Protein kinase, Ser/Thr (non-receptor) P50750 1025 9q34.11 human S175-p 456536 FGLARAFsLAKNSQP Pkinase molecular association, regulation; intracellular localization; enzymatic activity, inhibited; enzymatic activity, induced transcription, induced; transcription, altered TAT-SF1(DISRUPTS); LARP7(DISRUPTS); HEXIM1(DISRUPTS); CCNT1(INDUCES); TAT(INDUCES); BRD4(INDUCES); BRD4(NOT_REPORTED) 16109377; 21533037; 23658523; 28250118; 29743242 7 4 1 S175-p is found in nuclear speckles; CDK9 S175A mutant activates HIV-1 transcription; essential for mediating proviral reactivation by Tat (Molecular dynamics simulations); S175 CDK9 was recruited to the RNA-positive HIV-1 DNA; Mutation to A or D abrogates binding. Mutation to D activates the kinase (S->A abolishes kinase activity). The S->D mutation is defective as a transcription factor (due to no Brd4 binding which leads to less promoter binding and Mediator interactions). -Vdac1 VDAC1 Channel, misc.; Membrane protein, integral; Mitochondrial Q60932 22333 11 B1.3|11 31.86 cM mouse T55-p 1875831100 SENGLEFtSSGSANT Porin_3 molecular association, regulation HK2(DISRUPTS) 34949833 1 0 0 -Trpv4 TRPV4 Channel, cation; Membrane protein, integral; Membrane protein, multi-pass Q9EPK8 63873 5|5 F mouse S824-p 4777181 LRRDRWSsVVPRVVE activity, induced; protein stabilization; molecular association, regulation; intracellular localization apoptosis, inhibited Other(INDUCES) 22101010 8 3 0 S824D mutant shows enhanced interaction with F-actin -SHB SHB Adaptor/scaffold Q15464 6461 9p13.1 human Y336-p 451593 DDRPADEyDQPWEWN molecular association, regulation cell motility, induced; signaling pathway regulation ARHGAP2(INDUCES); ARHGAP3(INDUCES) 32060095 1 22 344 regulates EphB2 signaling -EPHA4 EphA4 EC 2.7.10.1; KINASE; Kinase, protein; Membrane protein, integral; Protein kinase, TK; Protein kinase, tyrosine (receptor) P54764 2043 2q36.1 human Y602-p 450857 TYVDPFTyEDPNQAV EphA2_TM molecular association, regulation; enzymatic activity, induced carcinogenesis, inhibited; cell motility, inhibited Fyn(INDUCES) 21439481; 36181793; 8622893 7 16 155 -Ptpn6 SHP-1 EC 3.1.3.48; Motility/polarity/chemotaxis; PHOSPHATASE; Protein phosphatase, tyrosine (non-receptor) P29351 15170 6 F2|6 59.17 cM mouse T394-p 23144271 TAEYKLRtLQISPLD Y_phosphatase phosphorylation; enzymatic activity, induced signaling pathway regulation 31011187 2 1 1 induces SYK dephosphorylation, induces phosphorylation of Lyn, regulates BCR signaling -H2bc15 H2B DNA-binding P10853 319187 13|13 A3.1 mouse S38-p 4702417 RSRKESYsVYVYKVL Histone chromatin organization, altered 19434510 0 9 4 regulation of senescence-related epigenetics modification -Amelx AMELX Secreted; Secreted, signal peptide P63277 11704 X F5|X 78.95 cM mouse S32-p 34729901 SPGYINLsYEKSHSQ Amelogenin cytoskeletal reorganization 31919099 4 1 0 regulate ACP phase transformation and enamel growth and amelogenesis, ameloblast integrity -ABL1 Abl EC 2.7.10.2; KINASE; Kinase, protein; Oncoprotein; Protein kinase, TK; Protein kinase, tyrosine (non-receptor) P00519 25 9q34.12 human Y257-p 450300 GGQYGEVyEGVWKKY PK_Tyr_Ser-Thr intracellular localization; protein conformation 21347248 4 13 323 -POLR2A POLR2A EC 2.7.7.48; EC 2.7.7.6; Nucleotide Metabolism - purine; Nucleotide Metabolism - pyrimidine; Transcription initiation complex; Transferase P24928 5430 17p13.1 human T1525-p 1239966001 TPWNQGAtPAYGAWS molecular association, regulation transcription, induced SPT6(INDUCES) 30135578 1 1 0 -Rplp2 RPLP2 Ribosomal; Translation P02401 140662 1q41 rat S105-p 454320 KKEESEEsDDDMGFG Ribosomal_60s activity, induced translation, altered 12379128 3 117 360 -Smo SMO Cell development/differentiation; GPCR, Fz/Smo family; Membrane protein, integral; Membrane protein, multi-pass; Oncoprotein; Receptor, GPCR P56726 319757 6 A3.3|6 12.36 cM mouse S599-p 1872776118 SFSMHTVsHDGPVAG molecular association, regulation transcription, induced PKACA(INDUCES) 33886552 1 1 0 -Syngap1 SynGAP iso3 GAP; GAP, Ras Q9QUH6-3 192117 20p12 rat S836-p 4792755 AGRLSQGsGSSITAA DUF3498 molecular association, regulation; intracellular localization HRas(INDUCES) 21382555 1 5 2 -Dlg1 DLG1 Adaptor/scaffold; Motility/polarity/chemotaxis Q62696 25252 11q22 rat S39-p 451614 SSIERVIsIFQSNLF L27_1 molecular association, regulation; intracellular localization NMDAR2A(INDUCES) 15044483; 17156128 3 0 0 facilitates the release of SAP97 from the endoplasmic reticulum; induces SAP97/NMDAR2A trafficking to the postsynaptic compartment -Dab2 DAB2 Adaptor/scaffold; Tumor suppressor O88797 79128 2q16 rat S24-p 451211 QAAPKAPsKKEKKKG molecular association, regulation transcription, altered MIB1(INDUCES) 11812785 4 3 0 -Klf10 KLF10 C2H2-type zinc finger protein; DNA-binding; Transcription factor O89091 21847 15|15 B3.1 mouse Y179-p 18958500 KAASILNyQDNSFRR ubiquitination; intracellular localization carcinogenesis, inhibited; cell differentiation, induced; transcription, inhibited 21471442 1 0 0 -Pth1r PTHR GPCR, family 2; Membrane protein, integral; Membrane protein, multi-pass; Receptor, GPCR P25961 56813 8q32 rat S492-p 2853102 RKARSGSsSYSYGPM receptor internalization, altered; activity, inhibited 11773434; 18577695 4 2 1 -CBL CBL Adaptor/scaffold; EC 6.3.2.-; EC 6.3.2.19; Ligase; Motility/polarity/chemotaxis; Oncoprotein; UBIQUITIN LIGASE; Ubiquitin conjugating system; Ubiquitin ligase P22681 867 11q23.3 human Y368-p 455273 IKVTQEQyELYCEMG molecular association, regulation; protein conformation; enzymatic activity, induced EGFR(INDUCES) 15117950 1 2 3 -MCM4 MCM4 DNA replication; EC 3.6.4.12 P33991 4173 8q11.21 human T110-p 450002 PRSGVRGtPVRQRPD activity, inhibited 12714602 2 20 7 -ERBB2 HER2 EC 2.7.10.1; KINASE; Kinase, protein; Membrane protein, integral; Oncoprotein; Protein kinase, TK; Protein kinase, tyrosine (receptor) P04626 2064 17q12 human Y735-p 458002 SGAFGTVyKGIWIPD PK_Tyr_Ser-Thr molecular association, regulation SHC1(INDUCES) 16729043 1 14 150 -AR AR DNA-binding; Nuclear receptor; Transcription factor P10275 367 Xq12 human S310-p 448413 TEDTAEYsPFKGGYT Androgen_recep protein stabilization; molecular association, regulation; activity, inhibited cell growth, inhibited; transcription, induced; transcription, inhibited; transcription, altered CREB3 iso3(INDUCES) DNA(DISRUPTS) 15684382; 17698582; 24441043; 25691442; 25851605; 31429764 11 5 0 -VIM Vimentin Cytoskeletal; Motility/polarity/chemotaxis P08670 7431 10p13 human S55-gl 5262500 TSRSLYAsSPGGVYA Filament_head intracellular localization 17507370 1 1 0 in the hyperphosphorylated head domain of vimentin -Gab1 GAB1 Adaptor/scaffold; Motility/polarity/chemotaxis Q9QYY0 14388 8|8 C2 mouse Y407-p 447946 DASSQDCyDIPRTFP molecular association, regulation cell differentiation, altered; cell growth, altered PLCG1(INDUCES) 10734310 4 37 1082 -CTCF CTCF C2H2-type zinc finger protein; Transcription factor; Tumor suppressor Q08705 396274 chicken S609-p 448303 MRSKKEDsSDSEENA transcription, altered; cell growth, altered 11238955 1 8 0 -LGR5 LGR5 GPCR, family 1; Membrane protein, integral; Membrane protein, multi-pass; Receptor, GPCR O75473 8549 12q21.1 human S864-p 27806300 VEKQSCDsTQALVTF receptor internalization, induced 23439653 1 0 0 constitutive internalization. Sites S844, S848, S851 and S854 may secondarily contribute to LGR5 internalization. -Pparg PPAR-gamma DNA-binding; Nuclear receptor; Transcription factor O88275 25664 4q42 rat S112-p 448062 AIKVEPAsPPYYSEK cell differentiation, induced; transcription, induced 35121022; 36840344 33 7 0 -ANAPC1 APC1 Cell cycle regulation; Ubiquitin conjugating system Q9H1A4 64682 2q13 human S377-p 455827 NISSHNQsPKRHSIS activity, induced 27120157 2 40 1 -NPFFR2 NPFFR2 GPCR, family 1; Membrane protein, integral; Membrane protein, multi-pass; Receptor, GPCR Q9Y5X5 10886 4q13.3 human S520-p 36533409 LKETTNSsEI_____ receptor desensitization, induced 25326382 1 1 0 -CDCP1 CDCP1 Cell surface; Membrane protein, integral Q9H5V8 64866 3p21.31 human Y707-p 451576 KGPAVGIyNDNINTE carcinogenesis, induced; cell growth, induced 25728678 2 12 313 Tyr734 is a key precursor phosphorylation event allowing Tyr707 and Tyr806 phosphorylation -Csf3r GCSFR Membrane protein, integral; Receptor, cytokine P40223 12986 4 D2.2|4 59.77 cM mouse K786-ub 4664705 GGPTPSPkSYENIWF carcinogenesis, inhibited; cell growth, induced; transcription, induced; signaling pathway regulation 18923646; 18931787 2 0 0 -Egfr EGFR EC 2.7.10.1; KINASE; Kinase, protein; Membrane protein, integral; Oncoprotein; Protein kinase, TK; Protein kinase, tyrosine (receptor) Q01279 13649 11 A2|11 9.41 cM mouse Y270-p 457625 TCPPLMLyNPTTYQM Furin-like molecular association, regulation EGFR(INDUCES) 15016810 1 0 0 -NR3C1 GR DNA-binding; Mitochondrial; Nuclear receptor; Transcription factor P04150 2908 5q31.3 human K492-ac 6741600 GMNLEARkTKKKIKG molecular association, regulation transcription, inhibited DNA(DISRUPTS) 19141540 1 0 0 -Camk2a CAMK2A EC 2.7.11.17; KINASE; Kinase, protein; Protein kinase, CAMK; Protein kinase, Ser/Thr (non-receptor) P11798 12322 18 E1|18 34.41 cM mouse T305-p 448802 KLKGAILtTMLATRN molecular association, regulation; enzymatic activity, inhibited; intracellular localization; phosphorylation neural plasticity NMDAR2B(DISRUPTS); Calmodulin(DISRUPTS) 12408851; 28636948; 33064361; 33853773 24 5 1 regulates phosphorylation at T286 and of GluA1 at S831 -PPARD PPAR-delta DNA-binding; Nuclear receptor A9XAM2 pig K16-ub 62484400 PEVREEEkKKEVAEA transcription, induced 24058710 1 0 0 -CDC34 CDC34 EC 6.3.2.19; Ligase; UBIQUITIN LIGASE; Ubiquitin conjugating system; Ubiquitin ligase P49427 997 19p13.3 human S222-p 448688 EVEEEADsCFGDDED intracellular localization 11546811 2 0 0 -Kcnj3 GIRK1 Channel, potassium; Membrane protein, integral; Membrane protein, multi-pass P63250 16519 2|2 C1.1 mouse Y12-p 457610 RRKFGDDyQVVTTSS activity, inhibited 19773548; 26377476 5 0 0 enhances channel deactivation; decreases channel conductance -TTK TTK Cancer Testis Antigen (CTA); EC 2.7.12.1; KINASE; Kinase, protein; Protein kinase, Other; Protein kinase, dual-specificity (non-receptor) P33981 7272 6q14.1 human S108-p 41389701 DKYGQNEsFARIQVR intracellular localization; enzymatic activity, induced 26119734 1 1 0 regulates spindle assembly checkpoint and recruitment of SAC proteins -PRKCQ PKCT EC 2.7.11.13; KINASE; Kinase, protein; Protein kinase, AGC; Protein kinase, Ser/Thr (non-receptor) Q04759 5588 10p15.1 human S676-p 447905 LNEKPRLsFADRALI Pkinase_C enzymatic activity, induced transcription, altered 11772397; 16252004 7 17 10 inhibits transcription; assayed in vitro -Fbxl21 FBXL21 UBIQUITIN LIGASE; Ubiquitin ligase Q8BFZ4 213311 13|13 B1 mouse S37-p 1880462804 LRQTHALsVLLDWGT enzymatic activity, induced cell differentiation, induced 36574402 1 0 0 induces MYOZ1 degradation -SLC22A6 SLC22A6 Membrane protein, integral; Membrane protein, multi-pass; Transporter; Transporter, SLC family Q4U2R8 9356 11q12.3 human K303-ub 53529107 GKREEGAkLSMEVLR Sugar_tr receptor internalization, induced 23640180 1 0 0 -RPS6KB1 p70S6K EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, AGC; Protein kinase, Ser/Thr (non-receptor); Translation P23443 6198 17q23.1 human S441-p 450015 SPRRFIGsPRTPVSP enzymatic activity, induced 7545671 11 31 89 -RPS6 S6 Translation P62753 6194 9p22.1 human S240-p 448094 RLSSLRAsTSKSESS carcinogenesis, induced; carcinogenesis, inhibited; apoptosis, induced; cell growth, induced; apoptosis, inhibited; autophagy, inhibited; signaling pathway regulation 33676898; 34762647; 36149602; 36715448; 37624695 111 69 847 -AGTR1 AT1 GPCR, family 1; Membrane protein, integral; Membrane protein, multi-pass; Receptor, GPCR P30556 185 3q24 human T332-p 467239 KSHSNLStKMSTLSY activity, induced; molecular association, regulation; intracellular localization; receptor internalization, altered ARRB1(INDUCES); ARRB2(INDUCES) 11579203; 15177932 3 0 0 -TP53 p53 Activator; DNA-binding; Motility/polarity/chemotaxis; Nuclear receptor co-regulator; Transcription factor; Tumor suppressor P04637 7157 17p13.1 human T387-p 455224 HKKLMFKtEGPDSD_ activity, induced; molecular association, regulation transcription, altered S100B(DISRUPTS); p53(INDUCES); 14-3-3 epsilon(INDUCES); 14-3-3 gamma(INDUCES); S100A2(DISRUPTS) DNA(INDUCES) 15659650; 18812399; 19819244; 19933256 3 1 0 -CCDC6 CCDC6 Apoptosis; Cytoskeletal; Oncoprotein Q16204 8030 10q21.2 human S244-p 450707 QPVSAPPsPRDISME DUF2046 activity, induced apoptosis, induced 14712216 3 100 40 -MAPK7 ERK5 EC 2.7.11.24; KINASE; Kinase, protein; Protein kinase, CMGC; Protein kinase, Ser/Thr (non-receptor) Q13164 5598 17p11.2 human S803-p 20572701 QREIQMDsPMLLADL intracellular localization; enzymatic activity, inhibited transcription, altered 20667468 1 4 0 -RBBP8 CtIP EC 3.1.-.-; Transcription, coactivator/corepressor Q99708 5932 18q11.2 human S664-p 448391 IDPGADLsQYKMDVT molecular association, regulation; enzymatic activity, induced BRCA1(DISRUPTS) 10910365; 24837676 2 1 0 -WWP2 WWP2 EC 6.3.2.-; EC 6.3.2.19; Ligase; UBIQUITIN LIGASE; Ubiquitin conjugating system; Ubiquitin ligase O00308 11060 16q22.1 human Y392-p 10369541 HFSQRFLyQSSSAST enzymatic activity, induced 35331737 1 0 1 -RAPGEF3 Epac1 iso3 GEF; GEF, misc. O95398-3 10411 12q13.11 human S108-p 54400804 GLGVHSRsQVVGICQ DEP intracellular localization 26929333 1 0 0 GRK2-mediated inhibition of Rap1 activation, inhibits plasma membrane association -RORC RORC DNA-binding; Nuclear receptor; Transcription factor P51449 6097 1q21.3 human S205-p 4708350 ASCHLEYsPERGKAE transcription, altered 35294872 1 3 0 -HIF1A HIF1A Autophagy; DNA-binding; Transcription factor Q16665 3091 14q23.2 human T555-p 34362821 NPFSTQDtDLDLEML HIF-1 protein degradation cell growth, inhibited; cell motility, inhibited; signaling pathway regulation 30254159 1 0 1 PI3K pathway and AKT are strongly activated by IRIS -Rps6ka3 RSK2 EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, AGC; Protein kinase, Ser/Thr (non-receptor) P18654 110651 X F4|X 73.27 cM mouse T577-p 450152 AENGLLMtPCYTANF Pkinase enzymatic activity, induced 10480933 10 14 180 -DNAJB8 DNAJB8 Chaperone Q8NHS0 165721 3q21.3 human K223-ac 7813482 KSVTVNGkEQLKWMD activity, induced 20159555 1 2 1 -FOXP3 FOXP3 C2H2-type zinc finger protein; Cell cycle regulation; DNA-binding; Transcription factor Q9BZS1 50943 Xp11.23 human K179-ac 31914101 PNPSAPRkDSTLSAV protein stabilization 23644046 1 0 0 -Ikzf1 Ikaros C2H2-type zinc finger protein; DNA-binding; Transcription factor Q03267 22778 11 A1|11 7.02 cM mouse S213-p 28735108 GRSYKQRsSLEEHKE zf-C2H2 molecular association, regulation; intracellular localization transcription, induced DNA(INDUCES) 23977012 1 1 0 nuclear localization, ITGA4, MDM1, EIF4E3, KIF23, TNFAIP8L2 DNA binding/transcription inhibited by BTK siRNA -PLA2G4A PLA2G4A EC 3.1.1.4; EC 3.1.1.5; Lipid Metabolism - alpha-linolenic acid; Lipid Metabolism - arachidonic acid; Lipid Metabolism - ether lipid; Lipid Metabolism - glycerophospholipid; Lipid Metabolism - linoleic acid; Phospholipase P47712 5321 1q31.1 human T376-p 1869344400 GSKFFMGtVVKKYEE PLA2_B enzymatic activity, induced carcinogenesis, induced; signaling pathway regulation 32559461 1 0 0 regulates mTORC2-PKC?-cPLA2 signaling -WBP2 WBP2 Cell development/differentiation; Nuclear receptor co-regulator Q969T9 23558 17q25.1 human Y231-p 464521 AEAAASAyYNPGNPH molecular association, regulation; intracellular localization carcinogenesis, induced; cell growth, induced; transcription, induced ER-alpha(INDUCES) 21642474 1 1 62 epithelial-mesenchymal transition induced -Ulk1 ULK1 Autophagy; EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, Other; Protein kinase, Ser/Thr (non-receptor) O70405 22241 5|5 F mouse S622-p 2047929 PLPPILGsPTKAGPS cell cycle regulation; autophagy, induced; cell growth, induced 32516310 1 30 2 -Rasgrf1 RASGRF1 GEF; GEF, Ras P28818 192213 8q31 rat S731-p 469604 PLAIGTSsPVRRRKL RasGEF_N protein degradation 16921254 1 2 1 causes nuclear disorganization in CHO cells -CNGA1 CNGA1 Channel, cation; Membrane protein, integral; Membrane protein, multi-pass Q00194 281700 cow Y503-p 27166602 QVYSPGDyICKKGDI cNMP_binding activity, inhibited 23032687 1 0 0 inhibits channel activity -PAK4 PAK4 EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, STE; Protein kinase, Ser/Thr (non-receptor) O96013 10298 19q13.2 human S99-p 2192540 MSVTRSNsLRRDSPP molecular association, regulation; intracellular localization; phosphorylation carcinogenesis, induced; cell motility, induced; cytoskeletal reorganization; cell motility, inhibited 14-3-3 zeta(INDUCES); 14-3-3 gamma(INDUCES) 23841590; 35593474; 35969127 3 12 0 -KIF22 KIF22 Microtubule-binding; Motor Q14807 3835 16p11.2 human T463-p 456110 QGAPLLStPKRERMV intracellular localization; activity, inhibited cell cycle regulation; cytoskeletal reorganization TUBA4A(DISRUPTS) 12727876; 27550518; 35730929 3 13 21 -Foxo1 FOXO1A DNA-binding; Nuclear receptor co-regulator; Oncoprotein; Transcription factor Q9R1E0 56458 3 C|3 23.19 cM mouse S209-p 4258803 SSAGWKNsIRHNLSL Forkhead protein stabilization 24453252 3 1 0 -Cldn16 Claudin-16 Cell adhesion; Membrane protein, integral; Membrane protein, multi-pass Q91Y55 155268 11q22 rat S217-p 2872000 AGVSMAKsYKAPRTE activity, induced; protein stabilization; intracellular localization 16608877 1 0 0 -TDP1 TDP1 DNA repair, damage; EC 3.1.4.-; Phosphodiesterase Q9NUW8 55775 14q32.11 human R586-m2 1883845001 ELYGSKDrPWIWNIP protein degradation; ubiquitination DNA repair, induced XRCC1(INDUCES); UCHL3(DISRUPTS) 35705029 1 0 0 -MEF2A MEF2A DNA-binding; Motility/polarity/chemotaxis; Transcription factor Q02078 4205 15q26.3 human T319-p 448098 TPVVSVTtPSLPPQG activity, induced transcription, altered 10849446; 9858528 2 0 0 -EIF2S2 eIF2-beta Translation; Translation initiation P20042 8894 20q11.22 human S2-p 451805 ______MsGDEMIFD translation, altered; cell growth, altered 16225457 4 52 0 -Cdh1 CDH1 Cell adhesion; Membrane protein, integral; Motility/polarity/chemotaxis; UBIQUITIN LIGASE; Ubiquitin ligase P09803 12550 8 D3|8 53.18 cM mouse S855-p 465567 SSLNSSEsDQDQDYD CADH_Y-type_LIR molecular association, regulation cell adhesion, altered CTNNB1(INDUCES) 10671552 3 0 0 -Ep300 p300 ACETYLTRANSFERASE; Acetyltransferase; EC 2.3.1.48; Motility/polarity/chemotaxis; Nuclear receptor co-regulator; Transcription, coactivator/corepressor B2RWS6 328572 15|15 E1 mouse S2276-p 486262 PAQPNPMsPQQHMLP phosphorylation transcription, induced 21498542 4 1 0 induces NFAT phosphorylation -Sptan1 SPTAN1 Adaptor/scaffold; Cytoskeletal; Motility/polarity/chemotaxis P16546 20740 2 B|2 20.93 cM mouse S1302-p 14828401 TAQRLIQsHPESAED Spectrin molecular association, regulation cell growth, altered 14-3-3 beta(INDUCES); NCAM1(INDUCES) 20598904 1 3 0 inhibits NCAM-stimulated neurite growth -Bach2 BACH2 DNA-binding; Transcription factor P97303 12014 4|4 A5 mouse K420-sm 2798316 PGPETLCkQEGELDR intracellular localization transcription, inhibited 15060166 2 0 0 formation of PML bodies -TNFAIP3 TNFAIP3 Apoptosis; DEUBIQUITINASE; EC 3.4.19.12; Protease; UBIQUITIN LIGASE; Ubiquitin conjugating system; Ubiquitin ligase P21580 7128 6q23.3 human S381-p 487535 EPSVPQLsLMDVKCE activity, induced; ubiquitination transcription, induced; signaling pathway regulation 17709380; 26649818; 31534238; 33154446 5 10 0 inhibit the NF-kB signaling pathway; regulates NF-kB signaling; cleavage of K63-linked tetraubiquitin ( all 4 sites or S381 alone), enhances ZnF4-mediated substrate ubiquitination; cell death inhibited (induces protective effect in A20-null cells); induces deubiquitination of its substrates -TRAF2 TRAF2 Autophagy; EC 6.3.2.-; Ligase; UBIQUITIN LIGASE; Ubiquitin conjugating system; Ubiquitin ligase Q12933 7186 9q34.3 human T117-p 471341 DGCTWKGtLKEYESC activity, induced 17188031 2 0 0 -Eif4ebp1 4E-BP1 Translation; Translation initiation Q62622 116636 16q12.3 rat S64-p 447527 FLMECRNsPVAKTPP eIF_4EBP molecular association, regulation translation, altered EIF4E(DISRUPTS) 10779345; 9806882 104 60 6 -PRKD3 PRKD3 EC 2.7.11.13; KINASE; Kinase, protein; Protein kinase, CAMK; Protein kinase, Ser/Thr (non-receptor) O94806 23683 2p22.2 human S735-p 456756 GEKSFRRsVVGTPAY Pkinase enzymatic activity, induced cell motility, induced 16198087; 24840177 2 46 52 Loss of Barbed End Formation for activities above basal level -CFLAR CFLAR Apoptosis O15519 8837 2q33.1 human T166-p 27811901 IHRIDLKtKIQKYKQ DED protein degradation; ubiquitination apoptosis, induced 23519470 2 1 0 concomitant sensitization of cancer cells to TRAIL-induced apoptosis; required for ROS-dependent degradation of CFLAR; mutation of T166, K167 or both ablates ROS-dependent CFLAR ubiquitination and degradation -SLC39A7 SLC39A7 Membrane protein, integral; Membrane protein, multi-pass; Transporter; Transporter, SLC family Q92504 7922 6p21.32 human S276-p 457020 STKEKQSsEEEEKET Zip activity, induced; phosphorylation exocytosis, induced; signaling pathway regulation 28205653; 31483418 2 19 9 maximal activation, SLC39A7 and Akt activation, zinc release and downstream effectors GSK3B, and p70 S6, phosphorylation of multiple kinases -Pag1 PAG Adaptor/scaffold; Membrane protein, integral Q9JM80 64019 2q23 rat Y381-p 463949 GEEPEPDyEAIQTLN PAG intracellular localization cytoskeletal reorganization; cell growth, altered 18498747; 19124084 3 16 90 -UPF1 RENT1 C2H2-type zinc finger protein; EC 3.6.1.-; EC 3.6.4.-; Hydrolase; RNA-binding Q92900 5976 19p13.11 human S1089-p 12559503 GLSQPELsQDSYLGD molecular association, regulation SMG7(INDUCES) 21965535 3 0 0 -CYLD CYLD DEUBIQUITINASE; EC 3.4.19.12; Protease; Tumor suppressor; Ubiquitin conjugating system; Ubiquitin-specific protease Q9NQC7 1540 16q12.1 human S772-p 31957308 LFKKIFPsLELNITD UCH enzymatic activity, induced 24614225 1 1 0 -RALB RALB G protein; G protein, monomeric; G protein, monomeric, Ras P11234 5899 2q14.2 human S198-p 16827200 KSSKNKKsFKERCCL intracellular localization carcinogenesis, altered; cell motility, altered; cytoskeletal reorganization; cell growth, altered 20940393 1 0 0 necessary for the development of experimental lung metastasis of human bladder cancer cells -HSP90AA1 HSP90A Chaperone; Heat shock protein P07900 3320 14q32.31 human Y197-p 459268 LKEDQTEyLEERRIK HSP90 molecular association, regulation; protein conformation CDK4(DISRUPTS); CDC37(DISRUPTS) 22727666; 23867252 2 7 178 phosphorylation induces altered conformation and governs drug specificity. -Nfatc1 NFAT2 DNA-binding; Transcription factor O88942 18018 18 E3|18 53.66 cM mouse S263-p 15412721 ARGSRPTsPCNKRKY intracellular localization; activity, inhibited cell differentiation, inhibited 31730830 2 7 16 -EHHADH EHHADH Amino Acid Metabolism - lysine degradation; Amino Acid Metabolism - tryptophan; Amino Acid Metabolism - valine, leucine and isoleucine degradation; Carbohydrate Metabolism - butanoate; Carbohydrate Metabolism - propanoate; EC 1.1.1.35; EC 4.2.1.17; EC 5.3.3.8; Isomerase; Lipid Metabolism - fatty acid; Lyase; Mitochondrial; Other Amino Acids Metabolism - beta-alanine; Oxidoreductase; Secondary Metabolites Metabolism - limonene and pinene degradation Q08426 1962 3q27.2 human K165-ac 14319820 ILADEALkLGILDKV ECH_1 enzymatic activity, induced 20167786 0 2 0 -MAD2L1 MAD2L1 Cell cycle regulation Q13257 4085 4q27 human S170-p 11280301 VPEKWEEsGPQFITN HORMA molecular association, regulation; protein conformation cell cycle regulation Mad1(DISRUPTS) 12574116; 21041666 2 0 0 -Nlrp3 NLRP3 Inhibitor Q8R4B8 216799 11|11 B1.3 mouse S3-p 38492201 _____MTsVRCKLAQ molecular association, regulation; activity, inhibited NLRP3(DISRUPTS); PYCARD(DISRUPTS) 34518217; 36872329 4 1 0 -CDC25B CDC25B EC 3.1.3.48; Motility/polarity/chemotaxis; Nuclear receptor co-regulator; PHOSPHATASE; Protein phosphatase, dual-specificity P30305 994 20p13 human S42-p 11452201 GSHGLLGsPVRAAAS cell growth, inhibited 25297629 1 4 0 induces immunogenicity, phospho-peptidesfor T-cell recognition showed some control of tumor growth in vivo -Ceacam1 CEACAM1 Cell adhesion; Immunoglobulin superfamily; Membrane protein, integral; Motility/polarity/chemotaxis P16573 81613 1q21 rat Y513-p 451429 SSPTETVySVVKKK_ activity, induced 7626603 5 2 37 Phosphorylation of CEACAM1 induces Ca2+/Mg2+-dependent ecto ATPase activity. -CETN2 CETN2 Calcium-binding; Cell cycle regulation; DNA repair, damage P41208 1069 Xq28 human T138-p 471512 KELGENLtDEELQEM EF-hand_7 molecular association, regulation XPC(DISRUPTS) 24918055 2 0 2 -HSPA1L HSPA1L Chaperone; Heat shock protein; Mitochondrial P34931 3305 6p21.33 human S241-p 1869383201 DFDNRLVsHFVEEFK HSP70 activity, induced apoptosis, inhibited; transcription, induced; signaling pathway regulation 31642047 1 0 0 induces chaperon activity of HSPA1L in vitro; heat stress-induced apoptosis -STK38 NDR1 EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, AGC; Protein kinase, Ser/Thr (non-receptor) Q15208 11329 6p21.31 human S91-p 1869478300 LGLEDFEsLKVIGRG Pkinase protein stabilization signaling pathway regulation 31690749 1 0 0 -USP16 USP16 DEUBIQUITINASE; EC 3.4.19.12; Protease; Ubiquitin conjugating system; Ubiquitin-specific protease Q9Y5T5 10600 21q21.3 human S386-p 50592104 HESFLDLsLPVLDDQ UCH enzymatic activity, induced 26323689 1 1 0 -HIP1 HIP1 Apoptosis; Cytoskeletal O00291 3092 7q11.23 human Y152-p 28704600 LLRTKMEyHTKNPRF ANTH cell growth, induced; apoptosis, inhibited 23836884 1 1 0 cell survival induced -FXN FXN EC 1.16.3.1; Mitochondrial; Motility/polarity/chemotaxis Q16595 2395 9q21.11 human Y118-p 41196502 EDLADKPyTFEDYDV Frataxin_Cyay ubiquitination 25948553 1 0 0 -MXD1 Mad1 DNA-binding; Transcription, coactivator/corepressor Q05195 4084 2p13.3 human S145-p 2807903 IERIRMDsIGSTVSS protein degradation; molecular association, regulation cell cycle regulation; transcription, induced; cell growth, altered DNA(INDUCES) 18451027; 19526459 2 0 0 inhibits MAD1-mediated transcription repression -Ola1 OLA1 EC 3.6.3.-; Hydrolase; Nucleolus Q9CZ30 67059 2|2 C3 mouse S232-p 1880539202 MVYLVNLsEKDYIRK protein stabilization; molecular association, regulation; ubiquitination; intracellular localization IMPA1(INDUCES) 36481055 1 1 0 inhibits ubiquitination -PPARG PPAR-gamma DNA-binding; Nuclear receptor; Transcription factor P37231 5468 3p25.2 human S112-p 448062 AIKVEPAsPPYYSEK sumoylation; protein degradation cell differentiation, altered; carcinogenesis, induced; signaling pathway regulation; transcription, inhibited; transcription, altered; cell growth, altered 11733495; 15507114; 16574647; 25409419; 26670611; 27687725; 34731634; 36139700; 37355990; 9030579; 9099735 33 7 0 -Irs2 IRS2 Adaptor/scaffold; Motility/polarity/chemotaxis P81122 384783 8 A1.1|8 5.35 cM mouse S1137-p 487314 QGGRRRHsSETFSST protein stabilization; molecular association, regulation transcription, induced 14-3-3 gamma(INDUCES) 23615913 1 9 27 -PKM PKM iso2 Carbohydrate Metabolism - glycolysis and gluconeogenesis; Carbohydrate Metabolism - pyruvate; EC 2.7.1.40; KINASE; Kinase, other; Mitochondrial; Nucleotide Metabolism - purine P14618-2 5315 15q23 human S37-p 476070 MCRLDIDsPPITARN enzymatic activity, inhibited; protein conformation 28607489 17 62 6 -Arap3 ARAP3 GAP; GAP, ARF; Motility/polarity/chemotaxis Q8R5G7 106952 18|18 B3 mouse Y1399-p 454957 DELEEPVyEEPVYEE cell motility, altered; cytoskeletal reorganization 15546919 3 0 0 -Fos Fos DNA-binding; Motility/polarity/chemotaxis; Oncoprotein; Transcription factor P12841 314322 6q31 rat T331-p 448484 CTPVVTCtPSCTTYT activity, induced; molecular association, regulation transcription, altered DNA(INDUCES) 17223854 4 0 0 -MYC Myc DNA-binding; Nucleolus; Oncoprotein; Transcription factor P01106 4609 8q24.21 human S267-p 466014 PPTTSSDsEEEQEDE Myc_N protein degradation; ubiquitination 22025562 2 0 0 S252 was the primary site for Myc degradation. -Aebp1 AEBP1 Secreted; Secreted, signal peptide; Transcription factor Q640N1 11568 11|11 A1 mouse T1003-p 455321 VDPSRPMtPQQRRMQ activity, induced transcription, inhibited 15654748 1 0 0 -DKFZp686G21220 DKFZp686G21220 Q6N090 human K109-ub 52490403 KDRINIIkDTSTNIV V-set protein degradation 26676607 0 1 0 -Itgb3 ITGB3 Cell adhesion; Membrane protein, integral; Motility/polarity/chemotaxis O54890 16416 11 E1|11 67.84 cM mouse Y784-p 448013 STFTNITyRGT____ Integrin_b_cyt molecular association, regulation; protein processing; activity, inhibited cell adhesion, altered SHC1(INDUCES) 10964917; 14519852; 16935858 21 2 6 -SLC9A3R1 NHERF Adaptor/scaffold; Motility/polarity/chemotaxis E2RGF3 dog S349-p 455753 RAHQKRSsKRAPQMD EBP50_C molecular association, regulation; intracellular localization; enzymatic activity, inhibited Ezrin(DISRUPTS); ARHGEF7(DISRUPTS) 22301917 5 1 12 Rac1 activity inhibited -Fos Fos DNA-binding; Motility/polarity/chemotaxis; Oncoprotein; Transcription factor P01101 14281 12 D2|12 39.7 cM mouse T232-p 448491 GGLPEAStPESEEAF activity, induced transcription, induced 8072547 6 0 0 -DICER1 DICER1 Cell development/differentiation; EC 3.1.26.3; Helicase; RNA processing; RNA-binding; Ribonuclease Q9UPY3 23405 14q32.13 human S1852-p 23098961 FSANVPRsPVRELLE DNA repair, induced 28642363 1 3 2 -CDT1 CDT1 DNA replication; DNA-binding; Motility/polarity/chemotaxis; Oncoprotein Q9H211 81620 16q24.3 human T402-p 20804634 PRPALPAtPPATPPA protein stabilization; molecular association, regulation; activity, inhibited; phosphorylation RAMP(DISRUPTS); MCM2(DISRUPTS) 21930785; 32841231 2 5 4 inhibits Chk1 phosphorylation -RNF7 RNF7 EC 6.3.2.-; Ligase; Motility/polarity/chemotaxis; UBIQUITIN LIGASE; Ubiquitin conjugating system; Ubiquitin ligase Q9UBF6 9616 3q23 human T10-p 449925 DVEDGEEtCALASHS protein degradation cell cycle regulation 12748192; 16874460 2 0 2 Phosphorylation of T10 of CKBBP1 is required for efficient degradation of I-kappa-B-alpha and P27/Kip1 -PHLPP1 PHLPP EC 3.1.3.16; PHOSPHATASE; Protein phosphatase, Ser/Thr (non-receptor); Tumor suppressor O60346 23239 18q21.33 human S335-p 15721886 PFVGGPVsSPRAPRP cell cycle regulation 33397691 1 4 0 -AATF AATF Nucleolus; RNA-binding; Transcription factor Q9NY61 26574 17q12 human S143-p 3753301 SKKSRSHsAKTPGFS protein stabilization; molecular association, regulation apoptosis, inhibited; transcription, altered NFkB-p65(INDUCES) DNA(INDUCES) 17157788 1 0 1 -MGMT MGMT Apoptosis; DNA repair, damage; EC 2.1.1.63; METHYLTRANSFERASE; Methyltransferase; Nuclear receptor co-regulator P16455 4255 10q26.3 human K165-ub 573761820 YSGGLAVkEWLLAHE DNA_binding_1 protein degradation 12036916 1 2 0 mutation of this site induces resistance to BG+BCNU chemotherapy by degradation inducing resynthesis of MGMT -Trpv1 TRPV1 Channel, cation; Membrane protein, integral; Membrane protein, multi-pass; Receptor, misc. O35433 83810 10q24 rat S116-p 454886 PRLYDRRsIFDAVAQ receptor desensitization, altered 12194871 6 1 0 -PRKAA1 AMPKA1 Autophagy; EC 2.7.11.1; EC 2.7.11.26; EC 2.7.11.27; EC 2.7.11.31; KINASE; Kinase, protein; Protein kinase, CAMK; Protein kinase, Ser/Thr (non-receptor) Q13131 5562 5p13.1 human S172-p 15407586 KIADFGLsNMMSDGE Pkinase activity, induced; enzymatic activity, induced carcinogenesis, inhibited; apoptosis, induced; apoptosis, inhibited; signaling pathway regulation 31679687; 33400734; 34418433; 35154579 8 1 4 -ACTA1 ACTA1 Cell development/differentiation; Contractile; Cytoskeletal; Motility/polarity/chemotaxis P68135 rabbit K52-ac 475524 VMVGMGQkDSYVGDE Actin activity, inhibited 30962575 1 6 58 CAP/actin inhibitory potency -Gch1 GCH1 Cofactor and Vitamin Metabolism - folate biosynthesis; EC 3.5.4.16; Hydrolase P22288 29244 15p14 rat T231-p 10428811 VFREDPKtREEFLTL GTP_cyclohydroI intracellular localization; enzymatic activity, inhibited 19762783 1 1 0 -STAT5A STAT5A DNA-binding; Motility/polarity/chemotaxis; Oncoprotein; Transcription factor P42229 6776 17q21.2 human Y694-p 447767 LAKAVDGyVKPQIKQ activity, induced; molecular association, regulation; intracellular localization carcinogenesis, induced; carcinogenesis, inhibited; cell growth, inhibited; apoptosis, induced; transcription, induced; signaling pathway regulation; transcription, altered; cell differentiation, induced; cell growth, induced; apoptosis, inhibited; transcription, inhibited STAT5A(DISRUPTS) DNA(DISRUPTS) 17726024; 18250158; 19088846; 21716071; 25885255; 31697835; 31932645; 34021045; 34188118; 35075244; 35154579; 36053753; 36460969 156 50 2180 -Dync1i2 DYNC1I2 Microtubule-binding; Motility/polarity/chemotaxis; Motor Q62871 116659 3q22 rat T95-p 469264 PSSKSVStPSEAGSQ intracellular localization cell cycle regulation 21507953 1 16 19 functions during prometaphase -HMGA1 HMGA1 DNA-binding P17096 3159 6p21.31 human S99-p 452256 KEEEEGIsQESSEEE cell growth, induced 29038488 3 64 173 -Was WASP Adaptor/scaffold; Motility/polarity/chemotaxis P70315 22376 X A1.1|X 3.65 cM mouse S501-p 449294 KRSRVIHsSDEGEDQ activity, induced cytoskeletal reorganization 24223520 2 10 0 -PML PML Nucleolus; Oncoprotein; SUMO LIGASE; SUMO conjugating system; SUMO ligase; Transcription factor; Tumor suppressor; Ubiquitin conjugating system P29590 5371 15q24.1 human K160-sm 2295400 EAHQWFLkHEARPLA zf-B_box protein degradation; molecular association, regulation; ubiquitination; intracellular localization; phosphorylation cell differentiation, inhibited; carcinogenesis, induced; cell differentiation, induced; transcription, induced; transcription, inhibited; cell growth, altered MDM2(DISRUPTS); PSME1(INDUCES); PIAS1(INDUCES); CK2A1(INDUCES); SUMO1(INDUCES); RNF4(INDUCES) 10779416; 11413191; 12759344; 12885887; 15710327; 17989716; 18408733; 19106612; 19380586; 20205709; 22406621; 23542129; 27099310; 27903803; 9756909 19 4 0 -CASP9 CASP9 Apoptosis; EC 3.4.22.62; Protease P55211 842 1p36.21 human Y251-p 1147026600 LQFPGAVyGTDGCPV Peptidase_C14 enzymatic activity, induced apoptosis, induced 29844931 1 0 0 -Relb RELB Transcription factor Q04863 19698 7 A3|7 9.93 cM mouse K274-ub 3055603 SEPVYDKkSTNTSEL transcription, induced 18620544 1 0 0 -ABCG2 ABCG2 Membrane protein, integral; Membrane protein, multi-pass; Transporter; Transporter, ABC family; Transporter, iron Q9UNQ0 9429 4q22.1 human T362-p 1818104 GEKKKKItVFKEISY activity, induced; molecular association, regulation; intracellular localization ABCG2(INDUCES) 18056989 2 0 0 drug resistance/efflux -TP53 p53 Activator; DNA-binding; Motility/polarity/chemotaxis; Nuclear receptor co-regulator; Transcription factor; Tumor suppressor P04637 7157 17p13.1 human K164-ac 2793003 VRAMAIYkQSQHMTE P53 activity, induced; acetylation; protein stabilization; molecular association, regulation; intracellular localization cell differentiation, induced; apoptosis, induced; transcription, induced; transcription, altered MDM2(DISRUPTS) 18485870; 19339993; 19377469; 21297583; 24038750; 25961455; 31680191; 33789902 12 1 0 recruit p300, CBP, and TIP60 onto PD-1 promoter, p53-mediated PD-1 transcription; 20, 164, 305, 320, 370/372/373, 381/382/386 K-R mutants diminsished transactivation, and selective regulation of target genes expression through distinct mechanisms -ENG ENG Membrane protein, integral; Motility/polarity/chemotaxis; Receptor, misc. P17813 2022 9q34.11 human T650-p 12064202 SIGSTQStPCSTSSM receptor internalization, induced; molecular association, regulation; phosphorylation signaling pathway regulation ARRB2(INDUCES) 22940691 2 0 0 TGF-beta-induced ITGB1 phosphorylation, integrin signaling and internalization -Cnn3 calponin 3 Cytoskeletal; Motility/polarity/chemotaxis Q9DAW9 71994 3|3 G1 mouse T288-p 34734351 IHNGSQGtGTNGSEI cell adhesion, induced; transcription, induced; cytoskeletal reorganization 31992794 1 0 7 induces formation of focal adhesions -Nfatc1 NFAT2 DNA-binding; Transcription factor O88942 18018 18 E3|18 53.66 cM mouse S243-p 4700879 PRHSPSTsPRASITE activity, inhibited transcription, inhibited 28920922 1 4 0 -TERF1 TRF1 DNA-binding P54274 7013 8q21.11 human S367-p 22996308 SRIPVSKsQPVTPEK protein degradation; molecular association, regulation; intracellular localization DNA(DISRUPTS) 22266654; 26586433 2 1 0 regulates telomere length and stability; lower telomere association across all phases of the cell cycle, elevated level of telomerase recruitment in G1 and G2/M phases -CBL CBL Adaptor/scaffold; EC 6.3.2.-; EC 6.3.2.19; Ligase; Motility/polarity/chemotaxis; Oncoprotein; UBIQUITIN LIGASE; Ubiquitin conjugating system; Ubiquitin ligase P22681 867 11q23.3 human S639-p 4704602 PDVPRLGsTFSLDTS molecular association, regulation 14-3-3 eta(INDUCES) 11024037 1 1 1 -Dusp4 DUSP4 EC 3.1.3.16; EC 3.1.3.48; PHOSPHATASE; Protein phosphatase, dual-specificity Q8BFV3 319520 8|8 A4 mouse S395-p 15412246 LHSPITTsPSC____ protein stabilization 22430215 2 1 2 -MAPK9 JNK2 EC 2.7.11.24; KINASE; Kinase, protein; Protein kinase, CMGC; Protein kinase, Ser/Thr (non-receptor) P45984 5601 5q35.3 human Y185-p 447652 TNFMMTPyVVTRYYR Pkinase cell cycle regulation; carcinogenesis, inhibited; apoptosis, induced; signaling pathway regulation 28068431; 35154579 75 39 1441 -CCNB1 CCNB1 Activator; Cell cycle regulation P14635 891 5q13.2 human S126-p 448814 PILVDTAsPSPMETS intracellular localization cell cycle regulation; carcinogenesis, induced DNA(INDUCES) 20117088; 22726437; 24582498; 24910099; 25849598 11 2 0 nuclear localization -EP300 p300 ACETYLTRANSFERASE; Acetyltransferase; EC 2.3.1.48; Motility/polarity/chemotaxis; Nuclear receptor co-regulator; Transcription, coactivator/corepressor Q09472 2033 22q13.2 human S2279-p 486262 PVQPNPMsPQQHMLP molecular association, regulation; enzymatic activity, induced transcription, altered SP1(NOT_REPORTED) 17623675 4 1 0 controls EGF-induced keratin 16 promoter activity ; regulates HAT activity of p300 -LIN28A LIN28A Nucleolus; RNA-binding; Translation Q9H9Z2 79727 1p36.11 human K177-ub 1883430201 MVASCPLkAQQGPSA protein degradation; molecular association, regulation 35262736 1 0 0 KAP1 binds to LIN28A and inhibits TRIM71 K177 ubiquitination and stabilizes LIN28A which may regulate let-7 miRNA levels -Nr1h3 LXR-alpha DNA-binding; Motility/polarity/chemotaxis; Nuclear receptor Q9Z0Y9 22259 2 E1|2 50.52 cM mouse K22-sm 1881122801 DSATELWkTEPQDAG protein degradation; ubiquitination 33125792 1 0 0 Sumoylation of LXR-alpha is necessary for polyubiquitylation and interaction with pSTAT1 and PIAS1 for degradation induced by IFN-gamma. May inhibit cholesterol effux mediated by ABCG1 from macrophages. -MDM2 MDM2 EC 6.3.2.-; EC 6.3.2.19; Inhibitor; Ligase; NEDDYLATION LIGASE; Neddylation Ligase; Nucleolus; Oncoprotein; UBIQUITIN LIGASE; Ubiquitin conjugating system; Ubiquitin ligase Q00987 4193 12q15 human Y394-p 455777 QSQESEDySQPSTSS apoptosis, induced; transcription, altered 12110584 2 0 0 -TRPC4 TRPC4 Channel, calcium; Membrane protein, integral; Membrane protein, multi-pass Q9UBN4 7223 13q13.3 human Y972-p 456714 DTVTHEDyVTTRL__ activity, induced; intracellular localization NHERF(INDUCES) 16144838 1 0 0 -KAT2B PCAF ACETYLTRANSFERASE; Acetyltransferase; EC 2.3.1.48; Nuclear receptor co-regulator Q92831 8850 3p24.3 human K441-ac 458987 SHVLEEAkKPRVMGD enzymatic activity, induced 12888487 1 0 0 in vitro -Cacng2 Stargazin Channel, calcium; Membrane protein, integral; Membrane protein, multi-pass O88602 12300 15 E1|15 36.92 cM mouse S228-p 455313 SAITRIPsYRYRYQR activity, induced; molecular association, regulation; intracellular localization neural plasticity ARC(DISRUPTS) 15664178; 20670832; 24882000; 25864631 5 1 2 regulates synaptic scaling -Dtna DTNA Motility/polarity/chemotaxis Q9D2N4 13527 18 A2|18 12.08 cM mouse Y705-p 1869344405 VPEDGDPyTQPEDGN protein stabilization; molecular association, regulation KAP(INDUCES) 32532815 1 0 0 -ESR1 ER-alpha DNA-binding; Nuclear receptor; Transcription factor P03372 2099 6q25.1-q25.2 human Y219-p 12620700 SIQGHNDyMCPATNQ zf-C4 protein stabilization; molecular association, regulation carcinogenesis, induced; cell growth, induced; transcription, induced; signaling pathway regulation ER-alpha(DISRUPTS) DNA(DISRUPTS) 20101225; 30692633 2 0 0 -Ncf1 p47phox EC 1.-.-.-; Oxidoreductase Q09014 17969 5 G2|5 74.47 cM mouse S346-p 451727 PGRPGPLsTDGTKDN intracellular localization 31438970 23 7 0 recruits NADPH oxidase to membranes -CDC25C CDC25C EC 3.1.3.48; Motility/polarity/chemotaxis; PHOSPHATASE; Protein phosphatase, dual-specificity P30307 995 5q31.2 human T67-p 448420 LSILSGGtPKRCLDL protein degradation; molecular association, regulation cell cycle regulation; cell adhesion, altered NEDD4(INDUCES); PIN1(INDUCES) 10037602; 20668692; 8119945 4 6 0 -MAPK14 P38A EC 2.7.11.24; KINASE; Kinase, protein; Protein kinase, CMGC; Protein kinase, Ser/Thr (non-receptor) Q16539 1432 6p21.31 human K53-ac 18575504 TGLRVAVkKLSRPFQ Pkinase molecular association, regulation; phosphorylation; enzymatic activity, induced apoptosis, induced Other(INDUCES) 21444723 1 1 0 induces ATP binding, induces phosphorylation of ATF2 -NUMB NUMB Cell development/differentiation P49757 8650 14q24.2-q24.3 human S7-p 487518 _MNKLRQsFRRKKDV intracellular localization endocytosis, induced; cell motility, induced AP2A1(DISRUPTS); PAR3(INDUCES); ITGB1(DISRUPTS) 17609107 2 3 1 -GABBR2 GABBR2 GPCR, family 3; Membrane protein, integral; Membrane protein, multi-pass; Receptor, GPCR O75899 9568 9q22.33 human K768-ub 54191603 QFTQNQKkEDSKTST protein degradation; ubiquitination 24114844; 26817839 2 0 0 -Nr3c1 GR DNA-binding; Mitochondrial; Nuclear receptor; Transcription factor P06536 24413 18p11 rat S287-p 3178938 TGDTILSsPSSVALP GCR intracellular localization transcription, induced 23878391 3 13 0 -Cnn3 calponin 3 Cytoskeletal; Motility/polarity/chemotaxis Q9DAW9 71994 3|3 G1 mouse S293-p 4776192 QGTGTNGsEISDSDY molecular association, regulation cell differentiation, induced; cytoskeletal reorganization ACTA1(INDUCES) 23276748 2 5 4 -TRPC5 TRPC5 Channel, cation; Membrane protein, integral; Membrane protein, multi-pass Q9UL62 7224 Xq23 human S796-p 20834808 GARAKSKsVSFNLGC intracellular localization; activity, inhibited signaling pathway regulation 21734191 1 0 0 -ETS1 Ets-1 DNA-binding; Motility/polarity/chemotaxis; Oncoprotein; Transcription factor P14921 2113 11q24.3 human S251-p 449316 GKLGGQDsFESIESY Ets1_N_flank molecular association, regulation; activity, inhibited transcription, inhibited DNA(DISRUPTS) 12475968 4 13 1 -ALDH1A1 ALDH1A1 Apoptosis; Cofactor and Vitamin Metabolism - retinol; EC 1.2.1.36; GAP; GAP, Ras; Oxidoreductase P00352 216 9q21.13 human T442-p 63070901 KDIDKAItISSALQA Aldedh protein stabilization; ubiquitination; intracellular localization; protein conformation; enzymatic activity, induced carcinogenesis, induced; cell motility, induced; cell growth, induced; transcription, induced ALDH1A1(DISRUPTS) 28193222 1 0 0 inhibits ubiquitination, induces drug resistance, T267 site ALDHA1A1 increases enzymatic activity, oligomers dissociate to the monomeric form -ASB2 ASB2 Unknown function Q96Q27 51676 14q32.12 human S371-p 29618900 RIRRSGVsPLHLAAE Ank_2 protein degradation; intracellular localization 24044920 1 1 0 Localization with and degradation of FLNa -FBP1 FBPase Carbohydrate Metabolism - fructose and mannose; Carbohydrate Metabolism - glycolysis and gluconeogenesis; Carbohydrate Metabolism - pentose phosphate pathway; EC 3.1.3.11; Mitochondrial; Phosphatase (non-protein) P09467 2203 9q22.32 human K113-ac 1876844500 VEPEKRGkYVVCFDP FBPase molecular association, regulation carcinogenesis, inhibited; transcription, inhibited BRD4(INDUCES) 32195024 1 0 0 -WRN WRN Cell cycle regulation; DNA repair, damage; DNA-binding; EC 3.6.4.12; Helicase; Nucleolus Q14191 7486 8p12 human S467-p 3196124 DTSYVIEsDEDLEME intracellular localization DNA repair, induced 24429382 1 14 2 localization to nucleoli, protection of cells from DSBs produced by etoposide -Cd5 CD5 Cell surface; Membrane protein, integral P13379 12507 19 A|19 7.16 cM mouse Y486-p 447775 DNSSDSDyDLQVAQR molecular association, regulation PIK3R1(NOT_REPORTED) 9079809 5 2 89 -Mapk1 ERK2 EC 2.7.11.24; KINASE; Kinase, protein; Protein kinase, CMGC; Protein kinase, Ser/Thr (non-receptor) P63086 116590 11q23 rat T183-p 447593 HDHTGFLtEYVATRW Pkinase activity, induced; molecular association, regulation; intracellular localization; enzymatic activity, induced translation, altered; cytoskeletal reorganization; cell adhesion, altered; signaling pathway regulation; cell growth, altered MEK1(INDUCES) 10473611; 10567369; 11731096; 12163549; 12595539; 12876277; 14627993; 15757502; 16368189; 19427337; 19943942; 20096547; 21357465; 21660950; 21738764; 21917714; 8444886 1139 120 2416 quercetin and myricetin-induced cardioprtection signaling; regulate cell proliferation in dentate gyrus following ischemia; phenylphrine induces protein synthesis; activation of MEK1 and ERK1/2; Arginine methyltransferase 5 induced signaling for cell proliferation and differentiation; focal adhesion inhibition/dissociation; integrin Rac1-NADPH oxidase signaling -HSD17B4 HSD17B4 Cell development/differentiation; EC 1.1.1.n12; EC 4.2.1.107; EC 4.2.1.119; Lipid Metabolism - primary bile acid biosynthesis; Lyase; Mitochondrial; Oxidoreductase P51659 3295 5q23.1 human K669-ac 461239 AKWTIDLkSGSGKVY SCP2 protein degradation carcinogenesis, inhibited; autophagy, induced 28296597; 32678070 2 4 1 -LSM4 LSM4 RNA-binding; Spliceosome Q9Y4Z0 25804 19p13.11 human R115-m2 60203700 GRGVFGGrGRGGIPG molecular association, regulation SMN(INDUCES) 11720283 1 1 0 -Htr2c 5-HT(2C) GPCR, family 1; Membrane protein, integral; Membrane protein, multi-pass; Receptor, GPCR P08909 25187 Xq34 rat S458-p 449090 NVVSERIsSV_____ molecular association, regulation; receptor desensitization, altered MPDZ(DISRUPTS) 10816555; 12682077 2 0 0 -CDK9 CDK9 Cell cycle regulation; EC 2.7.11.22; EC 2.7.11.23; KINASE; Kinase, protein; Nuclear receptor co-regulator; Protein kinase, CMGC; Protein kinase, Ser/Thr (non-receptor) P50750 1025 9q34.11 human Y19-p 1880104202 FCDEVSKyEKLAKIG protein stabilization; molecular association, regulation; intracellular localization; phosphorylation; enzymatic activity, induced carcinogenesis, induced; DNA repair, induced; cell growth, induced; transcription, induced SKP2(DISRUPTS) 36253486 1 0 0 -EXO1 EXO1 EC 3.1.-.-; Hydrolase Q9UQ84 9156 1q43 human S454-p 1240800 SEGNKSLsFSEVFVP protein degradation 18048416 1 2 0 -Dlg4 PSD-95 Adaptor/scaffold P31016 29495 10q24 rat S73-p 471390 ITLERGNsGLGFSIA PDZ molecular association, regulation; intracellular localization; activity, inhibited cell growth, altered NMDAR2A(DISRUPTS) 17156196; 19081375 6 4 0 enhances trafficking of SHANK2 and PSD-95 itself -Icos ICOS Membrane protein, integral Q9WVS0 54167 1 C2|1 30.6 cM mouse Y181-p 21511702 VHDPNSEyMFMAAVN molecular association, regulation PIK3CB(INDUCES); PIK3CD(INDUCES); PIK3R1(INDUCES); PIK3CA(INDUCES) 21188463 1 0 1 -SMARCA4 SMARCA4 Cell cycle regulation; EC 3.6.1.-; EC 3.6.4.-; Helicase; Nuclear receptor co-regulator; Transcription, coactivator/corepressor; Tumor suppressor P51532 6597 19p13.2 human K1033-ac 11317281 KKGKGGTkTLMNTIM SNF2-rel_dom DNA repair, induced; chromatin organization, altered 31291457 1 2 0 recruitment of SIRT1 is required for clearing nucleosomes and promoting HR at DNA DSB sites -CSF1R CSFR EC 2.7.10.1; KINASE; Kinase, protein; Membrane protein, integral; Oncoprotein; Protein kinase, TK; Protein kinase, tyrosine (receptor) P07333 1436 5q32 human Y723-p 448364 SSQGVDTyVEMRPVS PK_Tyr_Ser-Thr molecular association, regulation CBL(INDUCES) 10648820 15 0 1 -GLS glutaminase Amino Acid Metabolism - alanine, aspartate and glutamate; Amino Acid Metabolism - arginine and proline; EC 3.5.1.2; Energy Metabolism - nitrogen; Hydrolase; Mitochondrial; Other Amino Acids Metabolism - D-Glutamine and D-glutamate O94925 2744 2q32.2 human K164-sc 33361123 HKFITALkSTGLRTS EF-hand_14 protein degradation; protein stabilization; ubiquitination; succinylation carcinogenesis, inhibited; autophagy, induced; cell growth, inhibited 30910998; 31843902 2 1 0 suppresses its Lys48-linked ubiquitination; SIRT5 downregulated -NDEL1 NDEL1 Microtubule-binding; Protease Q9GZM8 81565 17p13.1 human T219-p 468252 ASLSLPAtPVGKGTE NUDE_C molecular association, regulation; intracellular localization PAFAH1B1(INDUCES); DYNC1I1(INDUCES) 12556484; 37086789 6 15 3 -SLC9A5 NHE5 Membrane protein, integral; Membrane protein, multi-pass; Transporter; Transporter, SLC family Q14940 6553 16q22.1 human S711-p 20832303 EEEEESDsSETEKED molecular association, regulation; activity, inhibited endocytosis, induced ARRB1(INDUCES) 21296876 1 0 0 -Keap1 KEAP1 Endoplasmic reticulum; Motility/polarity/chemotaxis; Transcription regulation; UBIQUITIN LIGASE; Ubiquitin conjugating system Q9Z2X8 50868 9|9 A3 mouse Y141-p 2708401 ERLIEFAyTASISVG BTB protein stabilization transcription, altered 18434303 1 0 0 INrf2 Y141A mutant fails to degrade Nrf2 -FGD1 FGD1 GEF; GEF, misc. P98174 2245 Xp11.22 human S205-p 3193805 LAPRAEAsPSSAAVS cell motility, altered 21212517 2 2 0 -CCP110 CP110 Cell cycle regulation O43303 9738 16p12.3 human S170-p 22351338 RDSEGFNsPKQCDSS intracellular localization cell cycle regulation 12361598 2 10 1 -LAT LAT iso2 Adaptor/scaffold; Membrane protein, integral O43561-2 27040 16p11.2 human Y132-p 447760 DDYHNPGyLVVLPDS LAT activity, induced; protein degradation; molecular association, regulation; ubiquitination; enzymatic activity, induced; phosphorylation cell differentiation, altered; signaling pathway regulation; transcription, altered GRB2(INDUCES); PLCG1(INDUCES); GADS(INDUCES); PLCG2(INDUCES) 11395491; 12496416; 24412752; 24642916; 27221712; 30510001; 34161759; 35124007 24 1 1 induces Erk and calcium signaling -OSBP OSBP Lipid-binding P16258 rabbit S195-p 452648 MLAESDEsGDEESVS molecular association, regulation; intracellular localization VAPA(INDUCES) 22875984 1 78 10 regulation of Sphingomyelin synthesis. S381A/S3D mutant has enhanced binding and altered localization -ROCK2 ROCK2 EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, AGC; Protein kinase, Ser/Thr (non-receptor) O75116 9475 2p25.1 human S1366-p 23003812 ARSSPRTsMKIQQNQ enzymatic activity, induced 22273145; 24168723 4 4 0 -RPL11 RPL11 Motility/polarity/chemotaxis; Nucleolus; Ribosomal; Translation P62913 6135 1p36.11 human K118-ne 12067611 EHIDLGIkYDPSIGI Ribosomal_L5_C protein stabilization; intracellular localization 19713960 1 0 0 -Elavl1 HuR RNA-binding P70372 15568 8 A1.1|8 2.0 cM mouse S318-p 2246702 GDKILQVsFKTNKSH molecular association, regulation translation, induced MYH9(INDUCES) 23921630 8 3 0 association is RNA dependent; Ang II mediated recruitment to polysomes -E2F4 E2F4 DNA-binding E1BUH4 chicken T263-p 25571900 STQPSTPtPSSTQDH cell cycle regulation; apoptosis, induced 22586272 1 0 0 -ABI1 Abi-1 Adaptor/scaffold; Motility/polarity/chemotaxis Q8IZP0 10006 10p12.1 human Y213-p 449523 PPTVPNDyMTSPARL protein degradation; molecular association, regulation; ubiquitination carcinogenesis, inhibited; endocytosis, altered; signaling pathway regulation PIK3R1(INDUCES) 20598684; 35839699 5 42 680 inhibits PI3K/Akt and Lyn pathways -Nek3 NEK3 EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, Other; Protein kinase, Ser/Thr (non-receptor) Q9R0A5 23954 8 A2|8 11.07 cM mouse T477-p 454368 PRLDEEDtDFEEDNE acetylation cytoskeletal reorganization 19509051 1 26 12 regulates neuronal morphology and polarity; regulates the level of alpha-tubulin acetylation (Ac-tubulin) -UBA2 SAE2 EC 6.3.2.-; EC 6.3.2.19; Ligase; Motility/polarity/chemotaxis; SUMO LIGASE; SUMO conjugating system; SUMO ligase; UBIQUITIN LIGASE; Ubiquitin conjugating system; Ubiquitin ligase Q9UBT2 10054 19q13.11 human K611-sm 27851103 SEEERSRkRKLDEKE UBA2_C intracellular localization 23095757 1 1 0 nuclear localization -DPYSL2 CRMP-2 iso3 Microtubule-binding; Motility/polarity/chemotaxis NP_001184222 1808 8p21.2 human S627-p 448082 PASSAKTsPAKQQAP protein stabilization; molecular association, regulation carcinogenesis, altered; cell growth, induced; cell motility, altered PIN1(INDUCES) 24036111; 26489457 31 49 84 axon growth in vitro -SFPQ PSF Nuclear receptor co-regulator; RNA splicing; RNA-binding P23246 6421 1p34.3 human Y293-p 482843 RRPGEKTyTQRCRLF intracellular localization transcription, altered; cell growth, altered RNA(INDUCES) 17537995 1 1 0 relocalization from nucleus to cytoplasm -TP63 p63 iso2 DNA-binding; Transcription factor Q9H3D4-2 8626 3q28 human S68-p 451601 TFDALSPsPAIPSNT protein degradation cell growth, inhibited 23166821; 30301786 6 2 0 Anti-clonogenic effects of TGFB require S66,68 phosphorylation. -Terf2 TRF2 DNA repair, damage; DNA-binding O35144 21750 8 D3|8 53.59 cM mouse S367-p 452842 ANLASPSsPAHKHKR molecular association, regulation cell cycle regulation RTEL1(DISRUPTS) 31723267 3 66 94 -TARDBP TDP-43 RNA-binding Q13148 23435 1p36.22 human S409-p 3084616 GSSMDSKsSGWGM__ molecular association, regulation; ubiquitination; intracellular localization; activity, inhibited; protein conformation; phosphorylation RNA splicing, induced; autophagy, induced; apoptosis, induced; RNA stability, inhibited; autophagy, altered; transcription, inhibited TDP-43(INDUCES); TDP-43(DISRUPTS) 19164285; 19515851; 21062285; 22198567; 24105464; 24466128; 24595055; 27445339; 28599005; 29311743; 29623031; 29987190; 30120199; 30559480; 34107054; 35112738 54 4 0 inhibited mTOR activity and dynactin expression, induced neuronal injury; primes phosphorylation at other sites; phosphomimetic S410/409D mutant reduces TARDBP aggregation and autophagy; induces cytotoxicity and oligomerization; promotes cytoplasmic aggregation -PTPRC CD45 EC 3.1.3.48; Membrane protein, integral; Motility/polarity/chemotaxis; PHOSPHATASE; Receptor protein phosphatase, tyrosine P08575 5788 1q31.3-q32.1 human Y1218-p 451644 MVSTFEQyQFLYDVI Y_phosphatase activity, induced; molecular association, regulation Lck(INDUCES) 7507203 1 0 1 -MCL1 MCL1 Apoptosis; Channel, misc.; Inhibitor; Membrane protein, integral; Mitochondrial Q07820 4170 1q21.2 human K40-ub 4953909 GRLLATEkEASARRE protein degradation apoptosis, inhibited 28522751; 30718431 2 7 41 DUB3-MCL1 drives chemoresistance in Ovarian Cancer via inhibition of apoptosis; HDACis and PaTrin-2 led to the ideal therapeutic effect -CASP3 CASP3 Apoptosis; EC 3.4.22.56; Motility/polarity/chemotaxis; Protease P42574 836 4q35.1 human S249-p 866032500 KVATEFEsFSFDATF Peptidase_C14 enzymatic activity, inhibited 29414778 1 0 0 -NCBP1 NCBP1 RNA processing; Spliceosome; Translation Q09161 4686 9q22.33 human S7-p 9764056 _MSRRRHsDENDGGQ RNA splicing, altered 10973943 1 20 17 -IL1R1 IL-1RA EC 2.7.11.25; Membrane protein, integral; Receptor, cytokine P14778 3554 2q11.2-q12.1 human Y496-p 450889 ELEKIQDyEKMPESI TIR molecular association, regulation PIK3R1(INDUCES) 9821957 1 0 0 -Camk2b CAMK2B EC 2.7.11.17; KINASE; Kinase, protein; Protein kinase, CAMK; Protein kinase, Ser/Thr (non-receptor) P08413 24245 14q21 rat S371-p 2020829 AITSPKGsLPPAALE molecular association, regulation cytoskeletal reorganization ACTB(DISRUPTS) 24866099; 26291163 2 5 0 inhibits interaction with F-actin, regulates synaptic plasticity; Transient phosphorylation promotes oligodendrocyte maturation. -GYS1 GYS1 Carbohydrate Metabolism - starch and sucrose; EC 2.4.1.11; Transferase P13834 100008660 rabbit S11-p 451605 SRTLSVSsLPGLEDW enzymatic activity, inhibited 10909964; 7929255 10 2 1 simultaneous mutation of both NH2- and COOH-terminal sites was necessary to cause substantial increases in the activity ratio. -SULT4A1 SULT4A1 EC 2.8.2.-; Transferase Q9BR01 25830 22q13.31 human T8-p 2021049 MAESEAEtPSTPGEF protein degradation; molecular association, regulation PIN1(INDUCES) 19439498; 20920535 2 1 0 -Mecp2 MECP2 Transcription, coactivator/corepressor Q9Z2D6 17257 X A7.3|X 37.63 cM mouse S421-p 470075 EKMPRGGsLESDGCP molecular association, regulation; intracellular localization neural plasticity; chromatin organization, altered; transcription, induced; cytoskeletal reorganization; transcription, inhibited DNA(DISRUPTS) 21765426; 21982370; 33551790; 34183865 15 13 0 -RRAS2 RRas2 G protein; G protein, monomeric; G protein, monomeric, Ras; Motility/polarity/chemotaxis; Oncoprotein P62070 22800 11p15.2 human S186-p 484150 QEQECPPsPEPTRKE carcinogenesis, induced 27086924 1 76 1 -YAP1 YAP1 iso2 Oncoprotein; Transcription, coactivator/corepressor P46937-2 10413 11q22.1 human S138-p 485036 SLQLGAVsPGTLTPT molecular association, regulation apoptosis, inhibited; transcription, induced TEAD1(INDUCES) 22308035 4 30 79 YAP phosphorylation is required for anti-apoptotic activity of YAP in cells which are deficient in p73 alpha/beta expression. -GAB1 GAB1 Adaptor/scaffold; Motility/polarity/chemotaxis Q13480 2549 4q31.21 human Y373-p 447945 ASDTDSSyCIPTAGM molecular association, regulation CDK6(INDUCES) 19881549 6 15 279 promotes HGF-induced DNA synthesis -LATS2 LATS2 EC 2.7.11.1; KINASE; Kinase, protein; Nuclear receptor co-regulator; Protein kinase, AGC; Protein kinase, Ser/Thr (non-receptor); Tumor suppressor Q9NRM7 26524 13q12.11 human S380-p 3213669 ATLARRDsLQKPGLE intracellular localization 21822051 2 13 9 chromosome segregation and cytokinesis ; translocation from the centrosome to the chromosome and spindle during mitosis -Stmn2 STMN2 Cytoskeletal P55821 20257 3 A1|3 2.15 cM mouse S62-p 450174 ELILKPPsPISEAPR Stathmin protein degradation cell motility, altered; cytoskeletal reorganization 21297631; 24469251 9 11 0 Phosphorylated SCG10 accumulates in THC-treated neurons after proteasomal inhibition.; phospho-mimetic S62D/S73D mutant stabilizes microtubules -TUBA1B TUBA1B Cytoskeletal; Motility/polarity/chemotaxis P68363 10376 12q13.12 human K40-m3 125970000 DGQMPSDkTIGGGDD Tubulin cell cycle regulation; cytoskeletal reorganization 27518565 2 1 0 -WDCP WDCP Q9H6R7 80304 2p23.3 human S686-p 3212568 RSDVFRDsFSHSPGA molecular association, regulation KIF2A(DISRUPTS); MRE11A(INDUCES) 30297404 1 7 1 mitotic spindle dynamics -Msx1 MSX1 DNA-binding; Motility/polarity/chemotaxis P13297 17701 5 B3|5 20.21 cM mouse K15-sm 12004422 TSLPLGVkVEDSAFA cell differentiation, inhibited; transcription, inhibited 16600910 2 1 0 PIAS1 binding to MSX1 is required for inhibiting cell differentiation and transcriptional repression, but sumoylation is not required -FLT4 VEGFR3 EC 2.7.10.1; KINASE; Kinase, protein; Membrane protein, integral; Protein kinase, TK; Protein kinase, tyrosine (receptor) P35916 2324 5q35.3 human Y1063-p 473000 FGLARDIyKDPDYVR PK_Tyr_Ser-Thr molecular association, regulation; enzymatic activity, induced apoptosis, inhibited SHC1(INDUCES); CRK(INDUCES) 16076871; 20431062 2 4 105 -CTTN Cortactin Actin-binding; Cytoskeletal; Motility/polarity/chemotaxis Q14247 2017 11q13.3 human S298-p 5014901 EKLAKHEsQQDYSKG HS1_rep molecular association, regulation; phosphorylation cell motility, altered; cytoskeletal reorganization; cell adhesion, inhibited 14-3-3 beta(INDUCES); CTNNB1(DISRUPTS); Vinculin(DISRUPTS) 19038333; 20363754; 27179075; 31727638 6 9 1 -IRS1 IRS1 Adaptor/scaffold; Motility/polarity/chemotaxis P35568 3667 2q36.3 human K1186-ub 1873529901 YIDLDLVkDFKQCPQ molecular association, regulation; phosphorylation cell growth, induced; signaling pathway regulation IGF1R(INDUCES) 33991522 1 0 0 regulates IRS1-tyrosine phosphorylation and IGF1-mediated downstream signaling -CDC42 CDC42 G protein; G protein, monomeric; G protein, monomeric, Rho; Motility/polarity/chemotaxis P60953 998 1p36.12 human K166-ub 12294209 ALTQKGLkNVFDEAI Ras protein degradation; molecular association, regulation carcinogenesis, inhibited; cell growth, inhibited; cytoskeletal reorganization PAK6(DISRUPTS) 28661476 1 3 6 -Kcnk2 TREK-1 Channel, potassium; Membrane protein, integral; Membrane protein, multi-pass P97438 16526 1|1 H6 mouse S315-p 456160 GDWLRVIsKKTKEEV activity, induced; activity, inhibited 16006563; 17916432; 22728824 4 0 0 -CHRM1 mAChR m1 GPCR, family 1; Membrane protein, integral; Membrane protein, multi-pass; Receptor, GPCR P11229 1128 11q12.3 human S273-p 54066607 PRLLQAYsWKEEEEE 7tm_1 molecular association, regulation ARRB1(INDUCES) 28652372 2 1 0 followed by arrestin-dependent ERK phosphorylation -SP3 SP3 C2H2-type zinc finger protein; DNA-binding Q02447 6670 2q31.1 human K551-sm 2407419 SPADIRIkEEEPDPE intracellular localization; activity, inhibited transcription, inhibited 12419227; 15247228; 15494207 3 3 0 -Ptpn6 SHP-1 EC 3.1.3.48; Motility/polarity/chemotaxis; PHOSPHATASE; Protein phosphatase, tyrosine (non-receptor) P81718 116689 4q42 rat Y538-p 448506 QRGQESEyGNITYPP molecular association, regulation PIK3R1(INDUCES) 9452499 20 24 637 -SH2D2A TSAd Adaptor/scaffold Q9NP31 9047 1q23.1 human Y305-p 450668 GEAPSNIyVEVEDEG molecular association, regulation Lck(INDUCES) 18541536 1 4 38 -Rictor RICTOR Adaptor/scaffold; Cell cycle regulation; Ubiquitin conjugating system Q6QI06 78757 15|15 A1 mouse T1135-p 458276 NRRIRTLtEPSVDLN RICTOR_phospho autophagy, inhibited; transcription, inhibited 34706731 11 14 173 -F3 F3 Cell surface; Membrane protein, integral P13726 2152 1p21.3 human K287-ub 15398676 AGVGQSWkENSPLNV ubiquitination; phosphorylation endocytosis, induced 27599717 1 3 2 -Pparg PPAR-gamma DNA-binding; Nuclear receptor; Transcription factor P37238 19016 6 E3|6 53.41 cM mouse Y78-p 36692605 SSISAPHyEDIPFTR PPARgamma_N cell motility, altered 26385316 2 1 0 suppresses the secretion of cytokines and chemokines from adipocytes -IRF8 IRF8 DNA-binding; Transcription factor Q02556 3394 16q24.1 human S151-p 1878257200 DELIKEPsVDDYMGM molecular association, regulation; phosphorylation cell cycle regulation; transcription, induced STING(INDUCES) 35973990 1 0 0 induces STING phosphorylation -TXN TXN Nuclear receptor co-regulator P10599 7295 9q31.3 human T76-p 28716000 CEVKCMPtFQFFKKG Thioredoxin protein degradation; ubiquitination; enzymatic activity, inhibited apoptosis, inhibited; transcription, inhibited; signaling pathway regulation 23747528 1 1 0 MPK38-mediated signaling through TGF-B, ASK1 and p53 -MAPK1 ERK2 EC 2.7.11.24; KINASE; Kinase, protein; Protein kinase, CMGC; Protein kinase, Ser/Thr (non-receptor) P28482 5594 22q11.22 human S29-p 7989100 GPRYTNLsYIGEGAY Pkinase molecular association, regulation; enzymatic activity, induced MEK2(INDUCES); MEK1(INDUCES) 19447520 1 0 0 -FANCD2 FANCD2 DNA repair, damage Q9BXW9 2177 3p25.3 human S64-p 1883582904 IILKTGEsQNQLAVD activity, induced; molecular association, regulation; ubiquitination; intracellular localization signaling pathway regulation DNA(INDUCES) 37392383 1 1 0 regulates the FA pathway -NEDD1 NEDD1 Cell cycle regulation Q8NHV4 121441 12q23.1 human S325-p 15421692 PTTVNKRsVNVNAAS molecular association, regulation cell cycle regulation TUBG1(DISRUPTS); SAS6(INDUCES) 33351100 2 5 3 regulation of cartwheel assembly and centriole biogenesis -Stat3 STAT3 DNA-binding; Motility/polarity/chemotaxis; Nuclear receptor co-regulator; Transcription factor P42227 20848 11 D|11 63.82 cM mouse K709-ac 7440601 AAPYLKTkFICVTPT acetylation; phosphorylation transcription, inhibited SIRT1(INDUCES) 19295512 1 1 0 SIRT1 downregulates phosphorylation at STAT3-Y705 and transactivation, deacetylation of STAT3 -SLC7A5 SLC7A5 Membrane protein, integral; Membrane protein, multi-pass; Transporter; Transporter, SLC family Q01650 8140 16q24.2 human K19-ub 6778621 AAPAAEEkEEAREKM protein degradation endocytosis, induced 31728037 1 10 36 PMA-induced endocytosis -CASP9 CASP9 Apoptosis; EC 3.4.22.62; Protease P55211 842 1p36.21 human Y397-p 286046008 AVSVKGIyKQMPGCF Peptidase_C14 enzymatic activity, inhibited 29066624 1 1 0 -Tiam1 TIAM1 GEF; GEF, Rac/Rho; Motility/polarity/chemotaxis; Oncoprotein Q60610 21844 16 C3.3|16 51.5 cM mouse Y829-p 465610 PQPEEDIyELLYKEI RBD cytoskeletal reorganization 16801538 2 0 0 important for BDNF-induced neurite outgrowth -DOCK7 DOCK7 GEF; GEF, misc. Q96N67 85440 1p31.3 human Y1257-p 2756301 METVPQLyDFTETHN molecular association, regulation; activity, inhibited carcinogenesis, inhibited; cell motility, altered; cell motility, inhibited BIN3(INDUCES) 18426980; 27018747; 35915159 3 0 0 -RBM17 RBM17 RNA splicing; RNA-binding; Spliceosome Q96I25 84991 10p15.1 human S204-p 476471 DSRPRSQsSKAAIPP molecular association, regulation; phosphorylation cell motility, induced; RNA stability, induced RNA(DISRUPTS) 23519612 1 1 0 induced cell invasion, enhanced Cortactin phosphorylation at ERK-dependent sites -Flt4 VEGFR3 EC 2.7.10.1; KINASE; Kinase, protein; Membrane protein, integral; Protein kinase, TK; Protein kinase, tyrosine (receptor) P35917 14257 11 B1.2|11 29.69 cM mouse Y1337-p 2874406 KVFYNNEyGEVSQPC cell growth, altered 7675451 4 1 2 -Ibsp Sialoprotein-2 Cell adhesion; Motility/polarity/chemotaxis; Secreted; Secreted, signal peptide P13839 rat S153-p 457545 KAPKMKEsDEEEEEE BSP_II activity, induced 20377527 2 2 0 important for hydroxyapatite (HA) nucleation -ARHGAP35 GRF-1 GAP; GAP, Rac/Rho; Motility/polarity/chemotaxis; Transcription factor; Tumor suppressor Q9NRY4 2909 19q13.32 human S1174-p 7157500 RFASYRTsFSVGSDD RhoGAP_pG1_pG2 molecular association, regulation; activity, inhibited RND1(DISRUPTS) 19103606 1 5 0 -Kifap3 KIFAP3 Adaptor/scaffold P70188 16579 1|1 H2.1 mouse S60-p 4711034 QKIIRLKsLNANTDI KAP molecular association, regulation; intracellular localization; phosphorylation cell differentiation, inhibited; cytoskeletal reorganization TRIM46(DISRUPTS) 31461655 1 37 13 primes phosphorylation at other sites -RAB3IP RAB3IP GEF; GEF, Rab Q96QF0 117177 12q15 human S288-p 4734219 KGHTRNKsTSSAMSG molecular association, regulation; intracellular localization cytoskeletal reorganization EXOC6(INDUCES) 23435566 2 18 0 inhibits binding to phosphatidylserine; ciliogenesis -ATF7 ATF7 C2H2-type zinc finger protein; DNA-binding; Transcription factor P17544 11016 12q13.13 human T51-p 467515 SVIIADQtPTPTRFL activity, induced; protein degradation; sumoylation; molecular association, regulation; ubiquitination transcription, induced; signaling pathway regulation TAF12(INDUCES) 18950637; 21858082 2 50 37 -Mef2c MEF2C DNA-binding; Transcription factor Q8CFN5 17260 13 C3|13 43.68 cM mouse S98-p 23068100 KGLNGCDsPDPDADD HJURP_C molecular association, regulation PIN1(INDUCES) 20801874 1 8 4 Pin1 binding decreases MEF2C stability and its transcriptional activity -Npm1 NPM1 Nucleolus; Oncoprotein; RNA-binding; Translation Q61937 18148 11|11 A4 mouse T95-p 456130 SLGGFEItPPVVLRL Nucleoplasmin protein conformation 24616519 2 18 18 -IL4R IL4R Membrane protein, integral; Receptor, cytokine P24394 3566 16p12.1 human Y713-p 451066 SLGSGIVySALTCHL molecular association, regulation apoptosis, inhibited; cell growth, altered SHIP(INDUCES) 11714803; 9670964 2 0 0 -GJA1 GJA1 Channel, misc.; Membrane protein, integral; Membrane protein, multi-pass; Motility/polarity/chemotaxis P17302 2697 6q22.31 human S373-p 459209 RASSRASsRPRPDDL activity, induced; molecular association, regulation; intracellular localization; protein conformation ZO1(DISRUPTS); ITGA5(INDUCES) 23828237; 24213533; 24563481; 29259079 19 7 0 gap junction communication; trophoblast cell fusion and syncytial hormone production; assembly of Cx43 at the plasma membrane -MXI1 Mad2 DNA-binding; Oncoprotein P50539 4601 10q25.2 human S195-p 1876620102 HGEVDNIsTTSISDI molecular association, regulation cell cycle regulation; carcinogenesis, inhibited; DNA repair, inhibited Mad1(INDUCES); CDC20(DISRUPTS) 35309941 1 0 0 -PIN1 PIN1 EC 5.2.1.8; Isomerase; Nuclear receptor co-regulator Q13526 5300 19p13.2 human S115-p 1873647702 SQFSDCSsAKARGDL Rotamase protein stabilization; ubiquitination carcinogenesis, induced; cell growth, induced; transcription, induced 34048060 1 1 0 inhibits ubiquitination (PIN1 mono-ubiquitination at Lys117 ) -Srebf1 SREBP-1 iso4 DNA-binding; Membrane protein, integral; Membrane protein, multi-pass; Transcription factor Q9WTN3-4 20787 11|11 B2 mouse S266-p 458357 IEKRYRSsINDKIVE HLH molecular association, regulation transcription, altered DNA(DISRUPTS) 19244231 4 1 0 regulates hepatic lipogenesis -IRX2 IRX2 DNA-binding; Transcription factor Q9PU52 373975 chicken S65-p 452192 AAATGFTsPLQYSTD transcription, altered 15133517 1 0 0 -PRKN PARK2 EC 6.3.2.-; EC 6.3.2.19; Ligase; Translation; Translation regulation; UBIQUITIN LIGASE; Ubiquitin conjugating system; Ubiquitin ligase O60260 5071 6q26 human S10-p 1434220100 VFVRFNSsHGFPVEV ubiquitin phosphorylation 23256036 1 1 0 S9, S10, S101 might be priming phosphorylation sites for S65 phosphorylarion -BECN1 beclin 1 Adaptor/scaffold; Autophagy; Membrane protein, peripheral Q14457 8678 17q21.31 human S96-p 472002 MSTESANsFTLIGEA molecular association, regulation carcinogenesis, inhibited; autophagy, induced; signaling pathway regulation DNAJB12(INDUCES); SLC7A11(INDUCES) 24685158; 30057310; 31220095 4 2 1 induces lipid peroxidation and ferroptosis; TM219-IGFBP3 signaling -Stim1 STIM1 Calcium-binding; Endoplasmic reticulum; Membrane protein, integral P70302 20866 7 E2-E3|7 54.71 cM mouse S608-p 3195758 PSVPPGGsPLLDSSH molecular association, regulation; protein conformation ORAI1(INDUCES); EB1(INDUCES) 20736304; 23687376 7 19 0 calcium mobilization and EB1-dependent STIM1 multimerization ; regulate store operated calcium entry (SOCE) -MACF1 ACF7 Actin-binding; Cytoskeletal; Motility/polarity/chemotaxis Q9UPN3 23499 1p34.3 human S7322-p 18507008 RAGSRAGsRASSRRG intracellular localization cell motility, induced; cytoskeletal reorganization 21295697 1 1 1 inhibits localization along microtubules, alters organization of microtubules, regulates skin wound repair, SC migration -STRAP STRAP Adaptor/scaffold; RNA splicing; UBIQUITIN LIGASE; Ubiquitin ligase Q9Y3F4 11171 12p12.3 human K156-ac 1876755702 ALWCSEDkQILSADD WD40 protein stabilization transcription, induced 32527012 1 0 0 upregulation and stabilization of p53 as well as its targets -Slc24a2 SLC24A2 Membrane protein, integral; Membrane protein, multi-pass; Transporter; Transporter, SLC family O54701 84550 5q32 rat T166-p 471069 VPSLTVItEKLGISD Na_Ca_ex activity, induced 17038313 1 0 0 Mutation to alanine of T476 and either T166 or S504 (or possibly both) eliminates PDBu-induced enhancement (PIE) on the Na(+)/Ca(2+)+K(+) exchanger. -SMARCA4 SMARCA4 Cell cycle regulation; EC 3.6.1.-; EC 3.6.4.-; Helicase; Nuclear receptor co-regulator; Transcription, coactivator/corepressor; Tumor suppressor P51532 6597 19p13.2 human S31-p 1261736700 PGAMLGPsPGPSPGS protein degradation; molecular association, regulation; ubiquitination FBXW7(INDUCES) 30177679 1 0 0 -CCAR1 CCAR1 Apoptosis; Nuclear receptor co-regulator; RNA splicing Q8IX12 55749 10q21.3 human S343-p 470613 RKRSRERsPRRERER protein stabilization; ubiquitination carcinogenesis, induced; cell growth, induced; apoptosis, inhibited; transcription, induced; signaling pathway regulation 35522902 1 1 0 inhibits ubiquitination of itself and induces ?-catenin stabilization, further inducing ?-catenin signalling -Oxtr OXTR GPCR, family 1; Membrane protein, integral; Membrane protein, multi-pass; Receptor, GPCR P70536 25342 4q41 rat S261-p 1876282800 AALARVSsVKLISKA 7tm_1 molecular association, regulation; phosphorylation signaling pathway regulation G-alpha(q)(INDUCES) 35104164 1 0 0 induces PKD1 and ERK1 phosphorylation, induces MAPK signaling -CENPU CENPU Cell cycle regulation Q71F23 79682 4q35.1 human S77-p 471407 TFDPPLHsTAIYADE protein degradation cell cycle regulation; cell growth, altered PLK1(INDUCES) 17081991 1 1 0 p-T78 peptides precipitated with Pl1K. Kinase activity of Plk1 is necessary for the in vivo interaction. The S77- T78 dependent interaction is sufficient to target Plk1 to the kinetochores. P-T78 dependent PBIP1 function is required for chromosome segregation, and is important for activation of spindle assembly checkpoint. -PTEN PTEN Carbohydrate Metabolism - inositol phosphate; EC 3.1.3.16; EC 3.1.3.48; EC 3.1.3.67; Motility/polarity/chemotaxis; Nuclear receptor co-regulator; PHOSPHATASE; Phosphatase, lipid; Tumor suppressor P60484 5728 10q23.31 human Y240-p 448316 RREDKFMyFEFPQPL PTEN_C2 enzymatic activity, induced cell growth, altered 11948419 3 1 0 -Tom1l1 Srcasm Adaptor/scaffold Q923U0 71943 11 D|11 55.47 cM mouse Y457-p 451210 APTTEAVyEEIDGYH molecular association, regulation cell growth, altered Fyn(INDUCES) 11711534; 17046829 4 2 35 mutation of this site promotes hyperproliferative phenotype -ULK1 ULK1 Autophagy; EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, Other; Protein kinase, Ser/Thr (non-receptor) O75385 8408 12q24.33 human S409-gl 1880900306 PSPSPPCsSSPSPSG protein stabilization; molecular association, regulation; phosphorylation autophagy, induced STX17(INDUCES); HSC70(DISRUPTS) 35931119 1 1 0 inhibits phosphorylation at S423 -GCK GK Carbohydrate Metabolism - amino sugar and nucleotide sugar; Carbohydrate Metabolism - galactose; Carbohydrate Metabolism - glycolysis and gluconeogenesis; Carbohydrate Metabolism - starch and sucrose; EC 2.7.1.2; Kinase, other; Mitochondrial P35557 2645 7p13 human K169-sm 27581516 GILLNWTkGFKASGA Hexokinase_1 protein stabilization; enzymatic activity, induced 23297408 1 1 0 -DDX1 DDX1 EC 3.6.4.13; Helicase; RNA-binding Q92499 1653 2p24.3 human S671-p 36406800 EHLNCTIsQVEPDIK molecular association, regulation RNA(INDUCES) 25176654 1 0 0 induces binding and maturatiuon of pri-miRNAs -PTK2B Pyk2 EC 2.7.10.2; KINASE; Kinase, protein; Nuclear receptor co-regulator; Protein kinase, TK; Protein kinase, tyrosine (non-receptor) Q14289 2185 8p21.2 human Y906-p 3091409 CQLPPEGyVVVVKNV Focal_AT molecular association, regulation SHP-2(INDUCES) 10880513 1 0 0 -PBXIP1 PBXIP1 Cytoskeletal Q96AQ6 57326 1q21.3 human S147-p 471206 REEGRCSsSDDDTDV protein degradation; ubiquitination transcription, induced; signaling pathway regulation 24488098 1 14 8 necessary for estrogen-mediated GREB1 expression; ERK1/2 and Akt1/3 signaling pathways -Bckdha BCKDH E1-alpha Amino Acid Metabolism - valine, leucine and isoleucine degradation; EC 1.2.4.4; Lyase; Mitochondrial; Oxidoreductase P50136 12039 7|7 A3 mouse S334-p 449636 TYRIGHHsTSDDSSA E1_dh activity, inhibited 24895126 10 60 24 decrease in plasma BCAA concentration -Wasf2 WAVE2 Actin-binding; Motility/polarity/chemotaxis Q8BH43 242687 4 D2.3|4 66.22 cM mouse S137-p 4258800 PPPLNNLsPYRDDGK cell motility, induced 22617848 2 0 0 regulate multipolar-bipolar neuron transition and growth cone activities -NUMA1 NuMA-1 Cell cycle regulation; Motility/polarity/chemotaxis Q14980 4926 11q13.4 human T1812-p 477991 RSARRRTtQIINITM cell growth, induced; apoptosis, inhibited 23097092 1 6 107 cell proliferation increased -OSTF1 OSTF1 Adaptor/scaffold; Motility/polarity/chemotaxis Q92882 26578 9q21.13 human S202-p 456078 TDAVRTLsNAEDYLD molecular association, regulation; intracellular localization carcinogenesis, induced; cell motility, induced MYO1E(DISRUPTS) 21501342; 27502487 2 27 12 -Exoc8 EXOC8 Vesicle O54924 245709 19q12 rat S505-p 25291117 QVFDSKEsLSTAAEC Exo84_C molecular association, regulation exocytosis, inhibited Sec5(DISRUPTS); EXOC8(DISRUPTS) 28325821 1 1 1 -GJA1 GJA1 Channel, misc.; Membrane protein, integral; Membrane protein, multi-pass; Motility/polarity/chemotaxis P17302 2697 6q22.31 human S328-p 449993 GQAGSTIsNSHAQPF Connexin43 protein conformation 23828237 10 13 0 -MEN1 MEN1 iso1 Transcription, coactivator/corepressor O00255-1 4221 11q13.1 human S548-p 470121 QVPAPTAsPPPEGPV Menin molecular association, regulation POLR2A(DISRUPTS) 21264250 2 16 1 -CCDC50 CCDC50 Inhibitor Q8IVM0 152137 3q28 human Y146-p 454596 AYADSYYyEDGGMKP molecular association, regulation EGFR(INDUCES) 16803894 1 5 18 inhibits the down-regulation of EGFR -ASIC2 ASIC2 Apoptosis; Channel, cation; Membrane protein, integral; Membrane protein, multi-pass; Transporter; Transporter, ion channel Q16515 40 17q11.2-q12 human T39-p 455992 IFVYGPLtIRRVLWA ASC; TM activity, induced 12399460 1 0 0 -Casp9 CASP9 Apoptosis; EC 3.4.22.62; Protease Q8C3Q9 12371 4|4 E1 mouse S348-p 484609 SQGRTLDsDSEPDAV Peptidase_C14 protein processing apoptosis, inhibited 18467326 1 6 0 inhibits protein cleavage by caspase 8 -MAD1L1 MAD1L1 Cell cycle regulation; Cytoskeletal Q9Y6D9 8379 7p22.3 human T708-p 5024703 PAFLSSLtLELFSRQ MAD intracellular localization 18922800 1 1 0 -ARHGEF2 ARHGEF2 iso2 GEF; GEF, Rac/Rho; Motility/polarity/chemotaxis Q92974-2 9181 1q22 human S885-p 451365 PVDPRRRsLPAGDAL molecular association, regulation; activity, inhibited; phosphorylation cytoskeletal reorganization; signaling pathway regulation 14-3-3 zeta(INDUCES) 22072711; 24352660 12 47 145 induces binding to microtubules, microtubule stabilization, inhibits MLC phosphorylation, modulates Rho signaling; represses RhoA-dependent stress fiber formation -Havcr1 TIM-1 Membrane protein, integral Q5QNS5 171283 11|11 B1.1 mouse Y299-p 20842101 SRAEDNIyIVEDRP_ signaling pathway regulation 21513984 2 0 7 regulates TIM-1 downstream signaling -Amph amphiphysin Vesicle Q7TQF7 218038 13 A2|13 6.89 cM mouse S293-p 465542 PAPVRPRsPSQTRKG molecular association, regulation endocytosis, altered endophilin A1(DISRUPTS) 23651931 4 1 2 -NUSAP1 NUSAP1 Cell cycle regulation; Nucleolus Q9BXS6 51203 15q15.1 human T338-p 3211263 GNSAAVItPFKLTTE NUSAP molecular association, regulation; intracellular localization cytoskeletal reorganization 22101338 1 13 4 inhibits NUSAP binding to microtubules in mitosis -CTNNB1 CTNNB1 Actin-binding; Cell adhesion; Motility/polarity/chemotaxis; Nuclear receptor co-regulator; Oncoprotein; Transcription factor P35222 1499 3p22.1 human K345-ac 459029 WTTSRVLkVLSVCSS activity, induced; molecular association, regulation transcription, induced TCF4(INDUCES); LEF-1(INDUCES); AR(DISRUPTS) 15060161; 26477307 2 0 0 -Cask CASK Adaptor/scaffold; EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, CAMK; Protein kinase, Ser/Thr (non-receptor) O70589 12361 X A1.1|X 8.43 cM mouse S395-p 1261102 DKINTKSsPQIRNPP L27 molecular association, regulation; intracellular localization liprin alpha 1(DISRUPTS) 18054859 1 3 0 promotes CASK recruitment to presynaptic membranes and interaction with presynaptic proteins (Veli, Mint1, neurexins, N-type voltage-gated calcium channels); ; promotes calcium influx into neurons; promotes synaptogenesis -DNMT3A DNMT3A Amino Acid Metabolism - cysteine and methionine; EC 2.1.1.37; METHYLTRANSFERASE; Methyltransferase; Methyltransferase, DNA Q9Y6K1 1788 2p23.3 human S255-p 4700048 QQPTDPAsPTVATTP molecular association, regulation; intracellular localization transcription, induced DNA(DISRUPTS) 25159139 2 13 0 blocks transcription of SOX9, collagen II and aggrecan -TBXA2R TXA2-R GPCR, family 1; Membrane protein, integral; Membrane protein, multi-pass; Receptor, GPCR P21731 6915 19p13.3 human S331-p 470029 STRPRSLsLQPQLTQ activity, induced; receptor desensitization, induced; molecular association, regulation; receptor desensitization, altered signaling pathway regulation 12370102; 17466390; 24490858 3 16 4 -MPZ myelin P0 Adaptor/scaffold; Membrane protein, integral P25189 4359 1q23.3 human S233-p 458933 SRSTKAVsEKKAKGL Myelin-PO_C intracellular localization 16493674 4 1 0 -Bcar1 P130Cas Adaptor/scaffold; Motility/polarity/chemotaxis Q61140 12927 8|8 E1 mouse Y169-p 448722 PSPATDLyQVPPGPG cell motility, altered 20430882 13 1 0 SH3 and CCH domains are required for P130Cas tyrosine phosphorylation and promoting cell migration. -RAF1 RAF1 EC 2.7.11.1; KINASE; Kinase, protein; Oncoprotein; Protein kinase, Ser/Thr (non-receptor); Protein kinase, TKL P04049 5894 3p25.2 human S233-p 448651 VSSQHRYsTPHAFTF molecular association, regulation 14-3-3 beta(INDUCES); HRas(DISRUPTS) 12801936 3 1 2 -RXRA RXRA DNA-binding; Motility/polarity/chemotaxis; Nuclear receptor P19793 6256 9q34.2 human Y249-p 456812 VEPKTETyVEANMGL activity, inhibited transcription, inhibited; transcription, altered 10938283; 20432439 2 0 0 -TNK2 Ack EC 2.7.10.2; EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, TK; Protein kinase, tyrosine (non-receptor) Q07912 10188 3q29 human Y859-p 448883 KKVSSTHyYLLPERP protein conformation; enzymatic activity, induced 36178070 3 34 584 -Erg ERG DNA-binding; Oncoprotein; Transcription factor P81270 13876 16 C4|16 56.04 cM mouse S222-p 9429097 VDKALQNsPRLMHAR intracellular localization 34314419 3 13 2 -Nos1 nNOS Amino Acid Metabolism - arginine and proline; EC 1.14.13.39; Oxidoreductase P29476 24598 12q16 rat K1321-ac 2459110 REPDRPKkYVQDVLQ NAD_binding_1 activity, induced 18415985 1 0 0 -CD28 CD28 Cell surface; Membrane protein, integral P10747 940 2q33.2 human Y191-p 450282 SRLLHSDyMNMTPRR molecular association, regulation transcription, inhibited CSK(INDUCES); GADS(INDUCES) 10820259; 20368329; 31292214 10 7 317 -LCP2 SLP76 Adaptor/scaffold Q13094 3937 5q35.1 human Y173-p 456736 FPNSNSMyIDRPPSG protein conformation; phosphorylation exocytosis, induced; transcription, induced; signaling pathway regulation 21725281; 31196981; 33931484 4 4 141 induces TCR signaling -STIM1 STIM1 Calcium-binding; Endoplasmic reticulum; Membrane protein, integral Q13586 6786 11p15.4 human S486-p 11485308 DMDEEIVsPLSMQSP activity, inhibited 19881501 2 0 0 involved in suppression of store-operated calcium entry during mitosis -TRAP1 HSP75 Chaperone; Heat shock protein Q12931 10131 16p13.3 human S568-p 27450720 EEKFEDRsPAAECLS HSP90 carcinogenesis, induced; cell growth, induced 28099845 1 4 0 -HSPB1 HSP27 Chaperone; Heat shock protein; Motility/polarity/chemotaxis; SUMO LIGASE; SUMO ligase Q00649 chicken S15-p 448401 FTFLTSPsWEPFRDW protein conformation 12429504 52 78 30 Mutations mimicking phosphorylation of sites single (S15D) and in combination form high and low molecular oligomers and affect chaperone activity in vitro. -CHFR CHFR EC 6.3.2.-; EC 6.3.2.19; Ligase; UBIQUITIN LIGASE; Ubiquitin conjugating system; Ubiquitin ligase Q96EP1 55743 12q24.33 human K384-ub 25090301 QSMDARNkITQDMLQ protein degradation cell cycle regulation 21768102 1 0 0 auto-ubiquitylation and CHFR degradation regulate the G2/M transition -Dnm1 DYN1 EC 3.6.5.5; Hydrolase; Microtubule-binding; Motility/polarity/chemotaxis; Motor; Vesicle P21575 140694 3p12 rat Y597-p 447606 NTEQRNVyKDYRQLE PH molecular association, regulation; receptor internalization, altered; activity, inhibited; protein conformation 12011079; 9880482 2 0 0 Y231/597F mutant Inhibits B2-AR internalization, and inhibited the isoproterenol mediated activation of ERK2.; Tyrosine phosphorylation promotes DYN1 self assembly. -EDC4 EDC4 RNA processing Q6P2E9 23644 16q22.1 human S583-p 4271998 PAPADFLsLSSETKP RNA stability, altered 30467221 1 5 15 increase formation of P bodies -GFI1 GFI1 C2H2-type zinc finger protein; Cell cycle regulation; Cell development/differentiation; Transcription factor Q99684 2672 1p22.1 human K8-m2 62504400 MPRSFLVkSKKAHSY molecular association, regulation; methylation carcinogenesis, induced; cell growth, induced; transcription, inhibited LSD1(INDUCES) 27480105 1 0 0 promotes H3K4 demethylation -MAX MAX iso2 DNA-binding; Transcription factor P61244-2 4149 14q23.3 human S2-p 449307 ______MsDNDDIEV activity, inhibited transcription, altered 8018564 5 35 0 phosphorylation-deficient mutant inhibits transcription more efficiently -PA2G4 Ebp1 Nuclear receptor co-regulator; Nucleolus; Transcription, coactivator/corepressor Q9UQ80 5036 12q13.2 human S363-p 981405 ALLQSSAsRKTQKKK molecular association, regulation; intracellular localization transcription, inhibited; cell growth, altered SIN3A(INDUCES); HDAC2(INDUCES) 17786317 1 4 0 nuclear localization -Adora3 ADORA3 GPCR, family 1; Membrane protein, integral; Membrane protein, multi-pass; Receptor, GPCR P28647 25370 2q34 rat T319-p 450330 DSNLEQTtE______ receptor desensitization, altered 10692494 1 0 0 -BCL10 Bcl-10 Apoptosis; Transcription, coactivator/corepressor; Tumor suppressor O95999 8915 1p22.3 human S136-p 15402376 ATNNLSRsNSDESNF activity, induced 21199863 1 1 1 -Pag1 PAG Adaptor/scaffold; Membrane protein, integral Q9JM80 64019 2q23 rat Y409-p 448996 LVPKENDyESIGDLQ PAG intracellular localization cytoskeletal reorganization; cell growth, altered 18498747; 19124084 3 38 657 -BAP1 BAP1 DEUBIQUITINASE; EC 3.4.19.12; Protease; Tumor suppressor; Ubiquitin conjugating system; Ubiquitin-specific protease Q92560 8314 3p21.1 human S571-p 31012815 LAEDGVLsPLALTEG intracellular localization DNA repair, induced 24347639 1 1 0 -CCNA2 CCNA2 Cell cycle regulation; Nuclear receptor co-regulator P20248 890 4q27 human K54-ac 7761214 RAALAVLkSGNPRGL Cyclin_N2 protein degradation; molecular association, regulation cell cycle regulation CDK2(DISRUPTS) 19483727; 23760262 2 1 0 -DYRK2 DYRK2 EC 2.7.12.1; KINASE; Kinase, protein; Protein kinase, CMGC; Protein kinase, dual-specificity (non-receptor) Q92630 8445 12q15 human T106-p 11489910 NKRTVLTtQPNGLTT protein stabilization; molecular association, regulation; intracellular localization MDM2(DISRUPTS) 19965871 2 1 0 -IKBKG IKKG Adaptor/scaffold; Protein kinase, regulatory subunit Q9Y6K9 8517 Xq28 human K277-sm 2255104 AEEALVAkQEVIDKL CC2-LZ molecular association, regulation; intracellular localization apoptosis, inhibited; transcription, induced ATM(INDUCES) 14651848; 16906147; 18583959; 20065354 6 0 0 -Cend1 CEND1 Membrane protein, integral Q9JKC6 57754 7|7 F5 mouse S10-p 10285828 SRGKSASsPKPDTKV CEND1 protein degradation; ubiquitination 35732922 1 8 0 -CHKA CHKA EC 2.7.1.32; EC 2.7.1.82; Kinase, other; Lipid Metabolism - glycerophospholipid P35790 1119 11q13.2 human Y333-p 21041605 LMLIDFEySSYNYRG Choline_kinase molecular association, regulation; enzymatic activity, induced carcinogenesis, induced; cell growth, induced; transcription, induced; translation, induced EGFR(INDUCES) 21822308 1 1 0 increases CHKA protein levels -APP APP Apoptosis; Cell surface; Membrane protein, integral; Receptor, misc.; Transcription factor P05067 351 21q21.3 human K763-sm 1881446403 GYENPTYkFFEQMQN protein stabilization; molecular association, regulation; intracellular localization transcription, induced Fe65(INDUCES) 32950104 1 0 0 increases CREB binding to the NEP promoter; NEP and TTR expression; nuclear translocation; reduces amyloid plaque deposits; decreases AB oligomerization, and amyloid plaque deposits -Ube3c UBE3C EC 6.3.2.-; EC 6.3.2.19; Ligase; UBIQUITIN LIGASE; Ubiquitin conjugating system; Ubiquitin ligase Q80U95 100763 5|5 B1 mouse S741-p 1884003508 EDAYDKLsPENEPDL protein stabilization; ubiquitination; enzymatic activity, inhibited 35914132 1 0 0 inhibits ubiquitination and degradation of PR -Ptprc CD45 EC 3.1.3.48; Membrane protein, integral; Motility/polarity/chemotaxis; PHOSPHATASE; Receptor protein phosphatase, tyrosine P06800 19264 1 E4|1 60.73 cM mouse S990-p 449972 SKESEPEsDESSDDD Y_phosphatase enzymatic activity, induced 10066810 1 4 0 -NTRK1 TrkA EC 2.7.10.1; KINASE; Kinase, protein; Membrane protein, integral; Oncoprotein; Protein kinase, TK; Protein kinase, tyrosine (receptor) P04629 4914 1q23.1 human Y496-p 447762 HIIENPQyFSDACVH molecular association, regulation; receptor internalization, altered; enzymatic activity, induced cell differentiation, altered; apoptosis, induced; cell growth, altered FRS2(INDUCES); SHC1(INDUCES); SHC1 iso2(INDUCES) 10617652; 10629055; 12237775; 15601748; 15955426; 8155326 23 0 2 regulate NGF induced neurite outgrowth and ERK activity -RIPK3 RIPK3 EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, Ser/Thr (non-receptor); Protein kinase, TKL Q9Y572 11035 14q12 human T165-p 1877504600 LADFGLStFQGGSQS Pkinase enzymatic activity, inhibited; phosphorylation 35739084 1 0 0 inhibits MLKL phosphorylation and necroptosis -SYK Syk EC 2.7.10.2; KINASE; Kinase, protein; Protein kinase, TK; Protein kinase, tyrosine (non-receptor) P43405 6850 9q22.2 human Y348-p 447659 LPMDTEVyESPYADP molecular association, regulation; enzymatic activity, induced ITGAM(INDUCES); PLCG1(INDUCES) 18818202; 30923129; 8657103 15 12 112 -TYMS TYMS Cofactor and Vitamin Metabolism - one carbon pool by folate; DNA repair, damage; EC 2.1.1.45; METHYLTRANSFERASE; Methyltransferase; Mitochondrial; Nucleotide Metabolism - pyrimidine P04818 7298 18p11.32 human S124-p 13209303 FLDSLGFsTREEGDL Thymidylat_synt molecular association, regulation; enzymatic activity, inhibited; protein conformation 20430630 2 1 0 incorrect binding alignment of substrate dUMP and THF to phosphorylated TYMS -MDM4 MDM4 EC 6.3.2.-; Ligase; UBIQUITIN LIGASE; Ubiquitin conjugating system; Ubiquitin ligase O15151 4194 1q32.1 human Y99-p 6039500 VKDPSPLyDMLRKNL protein stabilization; molecular association, regulation; protein conformation; phosphorylation 53BP1(DISRUPTS); p53(DISRUPTS) 19075013; 26148237; 29348869 3 1 0 -Plin1 perilipin 1 Lipid-binding Q8CGN5 103968 7|7 D2 mouse S517-p 471365 YSQLRKKs_______ activity, induced; molecular association, regulation ABHD5(DISRUPTS) 17114792; 19850935 11 0 1 stimulates perilipin-mediated lipolysis in adipocytes; induces dissociation of ABHD5 from perilipin and its association with Atgl -MAP1LC3A LC3A Autophagy; Microtubule-binding; Ubiquitin-like modifier; Vesicle Q9H492 84557 20q11.22 human S12-p 15116600 RPFKQRRsFADRCKE intracellular localization autophagy, altered 20713600; 27390127 2 1 0 -KAT5 Tip60 iso3 ACETYLTRANSFERASE; Acetyltransferase; EC 2.3.1.48; Nuclear receptor co-regulator; Nucleolus Q92993-3 10524 11q13.1 human S119-gl 1881440800 TKNGLPGsRPGSPER protein stabilization transcription, induced 34650217 1 0 0 accelerates EMT, HCC metastasis; inhibition of ubiquitylation; activation of TWIST1 by O-GlcNAcylation of TIP60 -IDH1 IDH1 Carbohydrate Metabolism - citrate (TCA) cycle; EC 1.1.1.42; Other Amino Acids Metabolism - glutathione; Oxidoreductase O75874 3417 2q34 human Y391-p 462261 PNVQRSDyLNTFEFM Iso_dh molecular association, regulation Other(INDUCES) 30862724 1 6 32 cofactor NADP+ binding to IDH1 -SRF SRF Motility/polarity/chemotaxis; Transcription factor P11831 6722 6p21.1 human S224-p 468829 TCLNSPDsPPRSDPT molecular association, regulation; acetylation; methylation transcription, induced MKL1(INDUCES) 34381779 1 45 2 regulates histone acetylation and methylation -ESRRA ERR1 DNA-binding; Nuclear receptor; Transcription regulation P11474 2101 11q13.1 human K68-ub 1877015602 PGEQGGGkLVLSSLP protein degradation cell differentiation, inhibited 31907393 1 0 0 -CACNA1C CACNA1C Channel, calcium; Membrane protein, integral; Membrane protein, multi-pass BAA34185.2 guinea pig T1603-p 7437803 RTALRIKtEGNLEQA Ca_chan_IQ activity, induced Calmodulin(INDUCES) 19340532 2 0 0 -GCSAM GCET2 Unknown function Q8N6F7 257144 3q13.2 human Y107-p 454098 GNSAEEYyENVPCKA HGAL activity, induced; molecular association, regulation signaling pathway regulation GRB2(INDUCES); GRB2(NOT_REPORTED) 17489982; 31362927 2 4 52 regulates B cell receptor signaling -Myb Myb DNA-binding; Oncoprotein; Transcription factor P06876 17863 10 A3|10 9.75 cM mouse K438-ac 459082 PCRDQTVkTQKENSI Cmyb_C molecular association, regulation transcription, induced CBP(INDUCES) 11073948 1 0 0 -BCL3 Bcl-3 Apoptosis; Nuclear receptor co-regulator; Oncoprotein; Transcription regulation P20749 602 19q13.32 human S454-p 31867760 PSPAPGGs_______ cell motility, induced; transcription, induced NFkB-p100(INDUCES) 28689659 1 2 0 -PRPF3 PRPF3 RNA processing; RNA splicing; Spliceosome O43395 9129 1q21.2 human T494-p 999610 TEAVQDPtKVEAHVR PRP3 molecular association, regulation; protein conformation cell growth, altered PRPF6(INDUCES); PRPF4(INDUCES) RNA(INDUCES) 17932117 1 0 0 T494M mutation weakens self association and association with PRPF4, PRP6, and U4 and U6 snRNAs. -FBXO43 FBX43 Unknown function Q4G163 286151 8q22.2 human T234-p 13419500 FSQQKTStIDDSKDD protein degradation; molecular association, regulation PLK1(INDUCES) 16407128 2 0 0 -MID1 MID1 Cytoskeletal; EC 6.3.2.-; EC 6.3.2.19; Ligase; UBIQUITIN LIGASE; Ubiquitin conjugating system; Ubiquitin ligase O15344 4281 Xp22.2 human S96-p 3245015 ASVSGPNsPSETRRE intracellular localization cell motility, inhibited 18949047 1 25 0 neural crest migration -HSF1 HSF1 DNA-binding; Transcription factor Q00613 3297 8q24.3 human S121-p 455480 NIKRKVTsVSTLKSE molecular association, regulation; intracellular localization; activity, inhibited HSP90A(INDUCES); ZAP(DISRUPTS) 16278218; 25425574; 29661921 5 7 1 -Cavin1 PTRF Transcription initiation complex O54724 19285 11 D|11 63.95 cM mouse Y158-p 458334 RNFKVMIyQDEVKLP PTRF_SDPR molecular association, regulation; intracellular localization IL33(DISRUPTS) 29977243 1 24 347 dephosphorylation of Y158 sequestered IL-33 in the nucleus limiting release -Gphn gephyrin Adaptor/scaffold; EC 2.10.1.1; EC 2.7.7.75 Q8BUV3 268566 12|12 C3 mouse S188-p 478376 DELEDLPsPPPPLSP molecular association, regulation PIN1(INDUCES) 17347650 3 43 1 -F2R PAR1 Cell development/differentiation; GPCR, family 1; Membrane protein, integral; Membrane protein, multi-pass; Receptor, GPCR P25116 2149 5q13.3 human Y383-p 451198 SECQRYVySILCCKE protein degradation; receptor internalization, altered 15023990 1 0 5 -Dll1 DLL1 Cell development/differentiation; Membrane protein, integral; Motility/polarity/chemotaxis Q61483 13388 17 A2|17 8.95 cM mouse S693-p 31012806 PDRKRPEsVYSTSKD transcription, induced 24449764 1 1 0 mutant shows increased stability -EXO1 EXO1 EC 3.1.-.-; Hydrolase Q9UQ84 9156 1q43 human T621-p 1240808 GLGDFSRtPSPSPST protein degradation 18048416 1 2 0 -NCOA2 SRC-2 Motility/polarity/chemotaxis; Nuclear receptor co-regulator; Transcription, coactivator/corepressor Q15596 10499 8q13.3 human K788-sm 2793921 LIAMKTEkEEMSFEP DUF4927 molecular association, regulation; intracellular localization transcription, induced AR(INDUCES) 12060666 1 0 0 AR-dependent transcription -Pxn PXN Adaptor/scaffold; Cell adhesion; Cytoskeletal; Motility/polarity/chemotaxis Q8VI36 19303 5 F|5 56.1 cM mouse Y88-p 448909 PPSPLPVySSSAKNS Paxillin carcinogenesis, induced; cell growth, altered 20133777 6 48 1343 -RG1 PPP1R3A Membrane protein, integral; Protein phosphatase, regulatory subunit Q00756 100009140 rabbit S48-p 449320 PQPSRRGsESSEEVY enzymatic activity, induced 8175660 5 5 0 -FOSL1 FRA1 DNA-binding; Transcription factor P15407 8061 11q13.1 human T223-p 1270901 HTPTLMTtPSLTPFT protein stabilization 17371847; 22286759 2 0 0 -IRF5 IRF5 DNA-binding; Transcription factor Q13568 3663 7q32.1 human S440-p 455995 ELSWSADsIRLQISN activity, induced; molecular association, regulation transcription, induced CBP(INDUCES) 12138184; 18836453 2 0 0 -Cyth2 cytohesin 2 GEF; GEF, ARF P63034 19158 7|7 B3 mouse Y381-p 4003314 AVSVDPFyEMLAARK activity, induced; molecular association, regulation ARF6(INDUCES); SH2-B-beta(INDUCES); GGA3(INDUCES) 35077201 1 0 33 -RGD1359108 C9orf72 Q66HC3 313155 rat S9-p 27720969 STICPPPsPAVAKTE protein degradation; ubiquitination autophagy, inhibited 37353944 1 6 0 -NAMPT PBEF Cell cycle regulation; Cofactor and Vitamin Metabolism - nicotinate and nicotinamide; Cytokine; EC 2.4.2.12; Transferase P43490 10135 7q22.3 human S314-p 40512819 PLIIRPDsGNPLDTV NAPRTase molecular association, regulation; enzymatic activity, induced DNA repair, induced; cell growth, induced Other(INDUCES) 36196536 1 2 0 induces binding to phosphoribosyl pyrophosphate -NR4A1 Nur77 Apoptosis; DNA-binding; Nuclear receptor P22736 3164 12q13.13 human Y60-p 41583608 FSTFMDGyTGEFDTF cell motility, induced; cell growth, induced; cytoskeletal reorganization 26155943 1 0 0 required for increase in cell growth, cell motility, monolayer permeability, and formation of actin stress fibers. -Cry1 CRY1 DNA-binding; Lyase; Transcription, coactivator/corepressor P97784 12952 10 C1|10 41.63 cM mouse S71-p 11952908 ANLRKLNsRLFVIRG DNA_photolyase protein degradation; molecular association, regulation PER2(DISRUPTS); FBXL3(INDUCES) 19833968; 31258021 3 0 0 contributes to changes in voluntary activity levels -Aqp2 AQP2 Channel, misc.; Membrane protein, integral; Membrane protein, multi-pass; Transporter; Transporter, aquaporin family P34080 25386 7q36 rat S261-p 464644 RQSVELHsPQSLPRG molecular association, regulation; ubiquitination; intracellular localization; activity, inhibited exocytosis, induced; endocytosis, inhibited GRP78(DISRUPTS); GDI2(DISRUPTS); HSP70(DISRUPTS); RAN(DISRUPTS); ANXA2(DISRUPTS); HSC70(DISRUPTS); PPP1CA(DISRUPTS) 19209902; 21148409; 21525134; 26147297; 27488997; 28668390; 32113684 38 9 0 -Kif23 KIF23 Microtubule-binding; Motility/polarity/chemotaxis; Motor E9Q5G3 71819 9|9 B mouse S905-p 459841 GSRKRRSsTLAPAQP intracellular localization cell cycle regulation; cytoskeletal reorganization 15199097 1 12 273 regulates cytokinesis -SQSTM1 SQSTM1 Autophagy; Nuclear receptor co-regulator; Ubiquitin conjugating system Q13501 8878 5q35.3 human T138-p 900975704 CNGPVVGtRYKCSVC ZZ apoptosis, induced 29519959 1 1 0 -GYS1 GYS1 Carbohydrate Metabolism - starch and sucrose; EC 2.4.1.11; Transferase P13807 2997 19q13.33 human S653-p 448240 PSLSRHSsPHQSEDE Glycogen_syn activity, inhibited 22510711 13 24 4 -TH TH Amino Acid Metabolism - tyrosine; EC 1.14.16.2; Endoplasmic reticulum; Mitochondrial; Oxidoreductase; Vesicle P07101 7054 11p15.5 human S19-p 448542 KGFRRAVsELDAKQA TOH_N molecular association, regulation; protein conformation; enzymatic activity, induced 14-3-3 zeta(INDUCES); 14-3-3 gamma(INDUCES) 16626642; 24055376; 34031189 46 9 4 -NCAPH2 NCAPH2 Cell cycle regulation; Endoplasmic reticulum; Membrane protein, integral Q6IBW4 29781 22q13.33 human S492-p 459636 FVQETELsQRIRDWE CNDH2_C intracellular localization cell cycle regulation 24934155 2 15 36 chromosome condensation -MITF MITF iso9 DNA-binding; Oncoprotein; Transcription factor O75030-9 4286 3p13 human S401-p 11125701 SSVSPGAsKTSSRRS DUF3371 protein degradation 25605940 1 1 1 -PRKCE PKCE EC 2.7.11.13; KINASE; Kinase, protein; Protein kinase, AGC; Protein kinase, Ser/Thr (non-receptor) Q02156 5581 2p21 human K534-sm 1870790710 GVIYRDLkLDNILLD Pkinase sumoylation; enzymatic activity, induced 33027667 1 0 0 PKCE phosphorylation is required for it's sumoylation; K534 sumoylation plays a critical role in the development of in?ammatory thermal hyperalgesia -Nrip1 RIP140 Nuclear receptor co-regulator; Transcription, coactivator/corepressor Q8CBD1 268903 16|16 C3.1 mouse K447-ac 458975 VPIDLSCkHRIEKPE NRIP1_repr_2 molecular association, regulation CTBP1(DISRUPTS) 11509661 1 0 0 loss of transcription repression -DTD1 DTD1 DNA replication; EC 3.1.-.-; Hydrolase Q8TEA8 92675 20p11.23 human S181-p 36396300 RAKGPSEsSKERNTP molecular association, regulation cell cycle regulation; cell growth, induced MCM7(INDUCES); MCM3(DISRUPTS) 25258324 1 0 0 decreases DTD1 incorporation into HMW, supports DNA replication initiation -H1-4 H1E DNA-binding P10412 3008 6p22.2 human S27-p 476058 VKKKARKsAGAAKRK molecular association, regulation CBX1(DISRUPTS); CBX3(DISRUPTS); HP1 alpha(DISRUPTS) 16127177 2 2 7 disrupts K26-methyl induced binding to HP1 -FYN Fyn EC 2.7.10.2; KINASE; Kinase, protein; Oncoprotein; Protein kinase, TK; Protein kinase, tyrosine (non-receptor) P06241 2534 6q21 human Y213-p 451536 RKLDNGGyYITTRAQ SH2 molecular association, regulation; intracellular localization; enzymatic activity, induced apoptosis, inhibited Exportin-1(INDUCES) 21097520; 27001024 2 39 1783 -Gucy1a1 GUCY1A1 EC 4.6.1.2; Guanylyl cyclase; Lyase; Nucleotide Metabolism - purine; Receptor, misc. P19686 497757 2q34 rat S107-p 450954 KIKENRNsSEKEDLE enzymatic activity, induced 14630997 1 1 0 -Prkce PKCE EC 2.7.11.13; KINASE; Kinase, protein; Protein kinase, AGC; Protein kinase, Ser/Thr (non-receptor) P16054 18754 17|17 E4 mouse T566-p 448787 MNGVTTTtFCGTPDY Pkinase enzymatic activity, induced 12640464 6 2 0 -ACE2 ACE2 EC 3.4.17.23; Membrane protein, integral; Protease Q9BYF1 59272 Xp22.2 human K112-ub 1880091002 SSVLSEDkSKRLNTI Peptidase_M2 protein degradation 35894122 1 1 0 -HBP1 HBP1 DNA-binding; Transcription factor O60381 26959 7q22.3 human S372-p 63253100 SAVYVLSsMARQRRA activity, induced; protein stabilization cell growth, inhibited; apoptosis, induced; transcription, altered DNA(INDUCES) 28348080 1 1 0 HBP1-mediated DNMT1 repression and p16 activation -GEM GEM G protein; G protein, monomeric; G protein, monomeric, RGK P55040 2669 8q22.1 human S261-p 450647 AYQKRKEsMPRKARR molecular association, regulation; intracellular localization cytoskeletal reorganization KPNA5(DISRUPTS) 14701738; 17605761 2 0 0 interaction abolished in triple phosphomimetic mutant S261/287/289D; Cell flattening and neurite extension; interaction increased in S261 alanine mutant -CD300LF IREM-1 Immunoglobulin superfamily; Membrane protein, integral; Receptor, misc. Q8TDQ1 146722 17q25.1 human Y249-p 474546 LPKEDISyASLTLGA SIT activity, induced; molecular association, regulation SHP-1(INDUCES) 17202342 2 0 0 mutation of site to Phe decreased the inhibitory activity of IREM-1 -SLC12A2 NKCC1 Membrane protein, integral; Membrane protein, multi-pass; Transporter; Transporter, SLC family P55011 6558 5q23.3 human S77-p 3192079 RPLGPTPsQSRFQVD activity, inhibited 24702155 2 16 7 Co-transporter activity of NKCC1 is reduced. -RPS6KA1 p90RSK EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, AGC; Protein kinase, Ser/Thr (non-receptor); Translation P18652 386579 chicken S398-p 447990 HQLFRGFsFVATGLM Pkinase_C molecular association, regulation; intracellular localization; enzymatic activity, induced PDK1(INDUCES) 11585927 66 48 64 -Ntrk2 TrkB EC 2.7.10.1; KINASE; Kinase, protein; Membrane protein, integral; Protein kinase, TK; Protein kinase, tyrosine (receptor) Q63604 25054 17p14 rat Y816-p 451754 LAKASPVyLDILG__ molecular association, regulation translation, altered; signaling pathway regulation PLCG1(INDUCES); CBL(INDUCES) 10533983; 22563458 20 0 0 c-fos protein synthesis induced by BDNF; activation of PLC-gamma1 and MAPK/PI3K signal transduction pathways -Dlc1 DLC1 GAP; GAP, Rac/Rho; Tumor suppressor Q9R0Z9 50768 8 A4|8 23.05 cM mouse S550-p 467752 DIPERRDsGVGASLT activity, induced; molecular association, regulation; activity, inhibited; phosphorylation carcinogenesis, inhibited; cell growth, inhibited; cytoskeletal reorganization; cell motility, inhibited tensin 2(INDUCES); DLC1(INDUCES) 23511482 1 17 8 Increased GAP activity further inhibiting RhoA activity; induces phosphorylation of S432 -CHRM2 mAChR M2 GPCR, family 1; Membrane protein, integral; Membrane protein, multi-pass; Receptor, GPCR P08172 1129 7q33 human T307-p 459106 EITQDENtVSTSLGH 7tm_1 receptor desensitization, altered; receptor internalization, altered 9162044 3 0 0 Mutation of 4 S/T to A eliminates receptor desensitization in response to carbachol treatment (as measured by isoproterenol-stimulated cAMP production after pretreatment with carbachol).; Mutation of S286 T287 S288 S290 to A caused a faster rate and a greater extent of receptor internalization after agonist stimulation (transients only, not observed in stables). Mutation of all 8 sites prevented internalization (in both transients and stables). -Ep300 p300 ACETYLTRANSFERASE; Acetyltransferase; EC 2.3.1.48; Motility/polarity/chemotaxis; Nuclear receptor co-regulator; Transcription, coactivator/corepressor B2RWS6 328572 15|15 E1 mouse S89-p 447592 SELLRSGsSPNLNMG molecular association, regulation transcription, altered; signaling pathway regulation; transcription, inhibited 14-3-3 epsilon(INDUCES); CTNNB1(INDUCES) 18849969; 33799418 14 2 0 Wnt/CBP/catenin signaling -MAPK7 ERK5 EC 2.7.11.24; KINASE; Kinase, protein; Protein kinase, CMGC; Protein kinase, Ser/Thr (non-receptor) Q13164 5598 17p11.2 human T733-p 455520 LPPVFSGtPKGSGAG intracellular localization; enzymatic activity, inhibited; phosphorylation; enzymatic activity, induced cell growth, induced; apoptosis, inhibited; transcription, induced; transcription, altered 20667468; 25689862; 29483645; 30132833; 31201162 7 13 1 MYCN protein; in DIPG cells -Cacnb2 CACNB2 iso2 Channel, calcium Q8VGC3-2 116600 17q12.3 rat T498-p 470081 RGLSRQEtFDSETQE molecular association, regulation; phosphorylation CAMK2A(INDUCES) 19840220 5 8 30 enhances phosphorylation of CACNB2 -MACF1 ACF7 Actin-binding; Cytoskeletal; Motility/polarity/chemotaxis Q9UPN3 23499 1p34.3 human S7226-p 18507015 GRRSKPSsRAASPTR intracellular localization cell motility, induced; cytoskeletal reorganization 21295697 1 2 0 inhibits localization along microtubules, alters organization of microtubules, regulates skin wound repair, SC migration -PINX1 PINX1 Inhibitor; Nucleolus; Tumor suppressor Q96BK5 54984 8p23.1 human S110-p 14823406 SDKKEKKsFSLEEKS protein degradation; ubiquitination 20573420 1 2 0 -SH2B1 SH2-B-beta Adaptor/scaffold Q9NRF2 25970 16p11.2 human S165-p 21336501 VGRSVRGsVRGILQW intracellular localization cell motility, induced; cell adhesion, altered 21878491 2 0 0 regulates focal adhesion size and number -orf9b Accessory protein 9b P0DTD2 SARSCoV2 K40-ub 1883454305 DQNNVGPkVYPIILR protein degradation; ubiquitination 35638730 1 0 0 reduces ORF9b-mediated IFN and NF-kB inhibition -AKT1 Akt1 EC 2.7.11.1; KINASE; Kinase, protein; Oncoprotein; Protein kinase, AGC; Protein kinase, Ser/Thr (non-receptor) P31749 207 14q32.33 human T312-gl 25538003 TMKTFCGtPEYLAPE Pkinase enzymatic activity, inhibited; phosphorylation 22629392 1 1 0 suppresses Akt phosphorylation at T308 by disrupting its interaction with PDK1 -CDK2 CDK2 Cell cycle regulation; EC 2.7.11.22; KINASE; Kinase, protein; Protein kinase, CMGC; Protein kinase, Ser/Thr (non-receptor) P24941 1017 12q13.2 human K33-ac 1876403700 TGEVVALkKIRLDTE Pkinase enzymatic activity, inhibited cell cycle regulation; cell growth, inhibited 19773423 1 0 0 -NCOA2 SRC-2 Motility/polarity/chemotaxis; Nuclear receptor co-regulator; Transcription, coactivator/corepressor Q15596 10499 8q13.3 human S487-p 4728845 GQPTSMLsPRHRMSP NCOA_u2 carcinogenesis, induced; cell motility, induced; cell growth, induced; transcription, induced; signaling pathway regulation 22158970; 33593309 2 9 1 induces SRC-2/CARM1 signaling -Rasgrp2 RASGRP2 GEF; GEF, Ras Q9QUG9 19395 19|19 A mouse S116-p 468584 QEGNRRHsSLIDIES activity, induced; molecular association, regulation 14-3-3 beta(INDUCES) 26804993 3 10 31 -ELAVL1 HuR RNA-binding Q15717 1994 19p13.2 human Y200-p 460123 VALLSQLyHSPARRF intracellular localization RNA(DISRUPTS) 24106086 1 17 234 blocks localization in stress granules, labile mRNA -Ctnnb1 CTNNB1 Actin-binding; Cell adhesion; Motility/polarity/chemotaxis; Nuclear receptor co-regulator; Oncoprotein; Transcription factor Q02248 12387 9 F4|9 72.19 cM mouse S675-p 457120 QDYKKRLsVELTSSL protein stabilization; intracellular localization carcinogenesis, induced; transcription, induced; signaling pathway regulation 22966074; 26884171; 30897078; 32102932; 33815677; 33824474; 36068223 40 55 17 induces EMT -PKM PKM Carbohydrate Metabolism - glycolysis and gluconeogenesis; Carbohydrate Metabolism - pyruvate; EC 2.7.1.40; KINASE; Kinase, other; Mitochondrial; Nucleotide Metabolism - purine P14618 5315 15q23 human K305-ac 474712 GIEIPAEkVFLAQKM PK protein degradation; molecular association, regulation; intracellular localization; enzymatic activity, inhibited; protein conformation carcinogenesis, induced; autophagy, induced; cell growth, induced HSC70(INDUCES); PKM(DISRUPTS) Other(DISRUPTS) 21700219; 25645022; 27197174 3 8 30 -Spn sialophorin Cell surface; Membrane protein, integral P15702 20737 7 F3|7 69.35 cM mouse S347-p 477870 RRKSRQGsLVLEELK intracellular localization cell motility, altered 17638845; 21289089 2 33 69 required for T cell trafficking to the lymph nodes; interaction with ezrin, radixin, moesin inhibits T cell migration -Pten PTEN Carbohydrate Metabolism - inositol phosphate; EC 3.1.3.16; EC 3.1.3.48; EC 3.1.3.67; Motility/polarity/chemotaxis; Nuclear receptor co-regulator; PHOSPHATASE; Phosphatase, lipid; Tumor suppressor O08586 19211 19 C1|19 28.14 cM mouse S385-p 448650 RYSDTTDsDPENEPF carcinogenesis, induced; cell motility, induced 22388104 12 10 0 -SLC40A1 SLC40A1 Membrane protein, integral; Membrane protein, multi-pass; Transporter; Transporter, SLC family Q9NP59 30061 2q32.2 human Y20-p 25589102 CCGSLADyLTSAKFL TM receptor internalization, inhibited 22682226 1 0 0 regulates internalization partially but not hepcidin mediated internalization -RECQL4 RECQL4 EC 3.6.4.12; Helicase O94761 9401 8q24.3 human K380-ac 7106309 LLRKQAWkQKWRKKG intracellular localization 19299466 1 0 0 accumulates in the cytoplasm -Sharpin SHARPIN Apoptosis Q91WA6 106025 15 D3|15 35.75 cM mouse K312-ub 21184654 GQSLQNSkMDRKLGL molecular association, regulation signaling pathway regulation ZAP70(INDUCES) 26829767 1 8 0 regulation of TCR signaling-maintenance of immuno; ogical signaling K63-linked polyubiquitination -AVPR2 AVPR2 GPCR, family 1; Membrane protein, integral; Membrane protein, multi-pass; Receptor, GPCR; Transporter; Transporter, aquaporin family P30518 554 Xq28 human S362-p 451067 DESCTTAsSSLAKDT intracellular localization 9482866 1 0 0 After receptor activation, phosphorylation of serines 362, 363, and 364 inhibits overall dephosphorylation of the internalized receptor, thereby inhibiting recycling of the receptor to the cell surface. -Map2k1 MEK1 EC 2.7.12.2; KINASE; Kinase, protein; Protein kinase, STE; Protein kinase, dual-specificity (non-receptor) P31938 26395 9 C|9 34.55 cM mouse S218-p 448514 VSGQLIDsMANSFVG Pkinase molecular association, regulation; enzymatic activity, induced cell growth, altered ERK1(INDUCES) 10749122; 16103085; 7731726; 8090753 124 13 83 -Egr2 EGR2 C2H2-type zinc finger protein; DNA-binding; EC 6.3.2.-; SUMO LIGASE; SUMO conjugating system; SUMO ligase P08152 13654 10 B5.1|10 34.96 cM mouse S349-p 1875113000 EGCDRRFsRSDELTR zf-C2H2 cell growth, induced; transcription, induced 34689593 1 0 0 -PCNA PCNA Cell cycle regulation; DNA replication P12004 5111 20p12.3 human K164-ub 485775 AVVISCAkDGVKFSA PCNA_C protein degradation; molecular association, regulation; ubiquitination cell cycle regulation; carcinogenesis, inhibited; apoptosis, induced; cell growth, inhibited; signaling pathway regulation; DNA repair, induced; DNA repair, altered; apoptosis, inhibited; DNA repair, inhibited POLH(INDUCES); WRNIP1(INDUCES) DNA(INDUCES) 12226657; 16482220; 16957771; 17130289; 18719106; 20129063; 22157819; 22692198; 23076824; 23761444; 26503230; 26549024; 27502483; 27753536; 28458162; 29281621; 30705406; 36228090 33 14 135 AKT inhibitors can by selectively killing homologous recombination (HR)-de?cient cells by inhibition of PCNA ubiquitylation; PCNA drive USP1 dependency in BRCA1/2 mutant tumors, USP1 inhibition and DNA damage leads to apoptosis -HEXIM1 HEXIM1 Motility/polarity/chemotaxis; Transcription factor O94992 10614 17q21.31 human K289-ub 9805701 MSKQELIkEYLELEK HEXIM transcription, inhibited 19617712 1 3 0 -MCOLN1 mucolipin 1 Channel, cation; Membrane protein, integral; Membrane protein, multi-pass; Transporter, ion channel Q9GZU1 57192 19p13.2 human S557-p 1233701 SGKFRRGsGSACSLL activity, inhibited 17988215 1 10 0 -IRF3 IRF3 DNA-binding; Transcription factor Q14653 3661 19q13.33 human K87-ub 25174501 FRSALNRkEGLRLAE IRF protein degradation; molecular association, regulation autophagy, induced CALCOCO2(INDUCES) 37330913 2 0 0 GPR108 and Smurf1 mediated degradation requires NDP52; NDP52-dependent autophagic degradation of phosphorylated IRF3; GPR108 interacts with Smurf1, followed by the recruitment of IRF3 during viral infection -LGALS3 galectin-3 Cell surface; Extracellular matrix; Motility/polarity/chemotaxis P17931 3958 14q22.3 human Y79-p 13213701 GAPAPGVyPGPPSGP protein stabilization carcinogenesis, induced; apoptosis, altered 20150913 2 1 0 -Add1 ADD1 Cytoskeletal; Motility/polarity/chemotaxis Q9QYC0 11518 5 B2|5 17.9 cM mouse S724-p 449829 KKKFRTPsFLKKSKK intracellular localization cell cycle regulation; neural plasticity; cytoskeletal reorganization 23424621; 33771994; 36539904 24 57 158 -AMOTL2 AMOTL2 Cell adhesion Q9Y2J4 51421 3q22.2 human K347-ub 52485000 EKAGRIEkLESEIQR molecular association, regulation; phosphorylation cell growth, inhibited; cell motility, inhibited; transcription, inhibited YAP1(INDUCES); LATS2(INDUCES) 26598551 1 2 0 -RET Ret iso3 EC 2.7.10.1; KINASE; Kinase, protein; Membrane protein, integral; Oncoprotein; Protein kinase, TK; Protein kinase, tyrosine (receptor) Q15300 5979 10q11.21 human Y586-p 447625 TWIENKLyGRISHAF molecular association, regulation SHC1(INDUCES) 9047384 42 2 2 -Cldn5 Claudin-5 Cytoskeletal; Membrane protein, integral; Membrane protein, multi-pass O54942 12741 16 A3|16 11.63 cM mouse T207-p 454390 YSAPRRPtANGDYDK activity, induced cytoskeletal reorganization 15383327 3 1 13 -Hsp90ab1 HSP90B Chaperone; Heat shock protein P11499 15516 17 B3|17 22.59 cM mouse S255-p 449266 PKIEDVGsDEEDDSG HSP90 molecular association, regulation; enzymatic activity, inhibited apoptosis, induced Akt1(DISRUPTS) 34645797 10 131 410 inhibits AKT phosphorylation -PML PML iso4 Nucleolus; Oncoprotein; SUMO LIGASE; SUMO conjugating system; SUMO ligase; Transcription factor; Tumor suppressor; Ubiquitin conjugating system P29590-4 5371 15q24.1 human S530-p 451473 DGPPSPRsPVIGSEV DUF3583 protein stabilization apoptosis, altered 15093545 2 29 17 Phosphorylation of PML is associated with enhanced sumoylation and apoptosis induced by As2O3. -SIRT6 SIRT6 DEACETYLASE; DEUBIQUITINASE; Deacetylase; EC 2.4.2.31; EC 3.5.1.-; Transferase Q8N6T7 51548 19p13.3 human K33-ub 1881229505 PPEELERkVWELARL protein degradation carcinogenesis, induced 33903120 1 0 0 -STXBP5L STXBP5L Q9Y2K9 9515 3q13.33 human S822-p 4724304 RSRSSSIsSIDKDSK Lgl_C protein degradation 25002582 1 4 3 ; in a multiple residue S->D mutant -Dnph1 DNPH1 EC 3.2.2.-; Hydrolase Q80VJ3 381101 17|17 C mouse S17-p 3175250 CSVYFCGsIRGGRED Nuc_deoxyrib_tr enzymatic activity, inhibited 20962348 1 8 0 contibutes to substrate binding and catalysis -OCLN occludin Cell adhesion; Membrane protein, integral; Membrane protein, multi-pass; Motility/polarity/chemotaxis Q16625 100506658 5q13.2 human Y402-p 458611 QDHYETDyTTGGESC molecular association, regulation; intracellular localization ZO1(INDUCES) 19017651 1 4 6 -SIRT2 SIRT2 DEACETYLASE; Deacetylase; EC 3.5.1.- Q8IXJ6 22933 19q13.2 human S25-p 1983913 QEAQDSDsDSEGGAA molecular association, regulation; intracellular localization transcription, induced DNA(DISRUPTS) 29694890 1 26 0 -Cited1 CITED1 Nuclear receptor co-regulator P97769 12705 X D|X 45.25 cM mouse S84-p 27937109 TPSSKPPsFNLHPTP CITED intracellular localization cell differentiation, induced 23529225 1 0 0 S63/64/65/67/69/73/79/80/84A mutation in CITED1 inhibits its translocation into the nucleus and osteoblasts differentiation -FBXL20 FBXL20 UBIQUITIN LIGASE; Ubiquitin ligase Q96IG2 84961 17q12 human S143-p 1875005602 TSLSKFCsKLRHLDL LRR_6 protein degradation; molecular association, regulation carcinogenesis, inhibited; cell growth, inhibited; apoptosis, induced FBXO31(INDUCES) 34587475 1 0 0 -C5AR1 C5aR GPCR, family 1; Membrane protein, integral; Membrane protein, multi-pass; Receptor, GPCR P21730 728 19q13.32 human S327-p 448821 RNVLTEEsVVRESKS molecular association, regulation; receptor desensitization, altered ARRB1(INDUCES); ARRB2(INDUCES) 12464600; 17145764 4 17 37 induces translocation of beta-arrestin into the plasma membrane -SSTR2 SSTR2 GPCR, family 1; Membrane protein, integral; Membrane protein, multi-pass; Receptor, GPCR P30874 6752 17q25.1 human T353-p 7652102 DKSRLNEtTETQRTL receptor internalization, induced; receptor desensitization, induced; receptor recycling, induced 24565897; 24637622 9 0 1 -RACK1 RACK1 Adaptor/scaffold; G protein; G protein, heterotrimeric; G protein, heterotrimeric beta; Motility/polarity/chemotaxis; Nuclear receptor co-regulator P63244 10399 5q35.3 human S278-p 1874704200 KQEVISTsSKAEPPQ WD40 translation, induced 34496247 1 0 0 -WDR44 WDR44 Motility/polarity/chemotaxis; Vesicle Q5JSH3 54521 Xq24 human S344-p 480095 PQRPRSNsGRELTDE molecular association, regulation; protein conformation RAB11A(INDUCES) 36463963 1 15 53 -SREBF2 SREBP-2 DNA-binding; Membrane protein, integral; Membrane protein, multi-pass; Transcription factor Q12772 6721 22q13.2 human S432-p 451007 NQNVLLMsPPASDSG transcription, induced 14988395 1 0 0 -Smad2 SMAD2 DNA-binding; Transcription factor Q62432 17126 18 E3|18 51.42 cM mouse S465-p 447494 SPSVRCSsMS_____ molecular association, regulation; intracellular localization carcinogenesis, induced; cell growth, induced; cell motility, induced; cell growth, inhibited; cell differentiation, induced; transcription, induced; signaling pathway regulation SMAD4(INDUCES) 32122971; 34655614; 34799661; 35538070; 37350664 57 1 5 -Spi1 PU.1 DNA-binding; Oncoprotein; Transcription factor P17433 20375 2 E1|2 50.44 cM mouse S133-p 478390 SPAHQQSsDEEEGER molecular association, regulation IRF8(INDUCES); PU.1(INDUCES); IRF2(INDUCES) 17200120 1 1 0 Interaction of PU.1, IRF-2, and IRF-8 requires phosphorylated residues on each protein. -Bmal1 BMAL1 DNA-binding; Transcription factor Q9WTL8 11865 7 F1|7 59.17 cM mouse S97-p 7359500 RRRDKMNsFIDELAS HLH molecular association, regulation; intracellular localization; protein conformation apoptosis, inhibited; transcription, induced; transcription, altered 19330005; 24312621 3 0 0 critical oxidative stress-responsive circadian transcriptome; regulates circadian gene expression; BMAL1-HSF1 dimerization -ITGB4 ITGB4 Cell adhesion; Membrane protein, integral; Motility/polarity/chemotaxis; Receptor, misc. P16144 3691 17q25.1 human S1325-p 3103700 TQPKRPMsIPIIPDI molecular association, regulation Plectin-1(INDUCES) 15817481 1 0 0 -ACTR3 Arp3 Cytoskeletal; Motility/polarity/chemotaxis P61158 10096 2q14.1 human S418-p 480945 NPVFGVMs_______ cell motility, induced; cytoskeletal reorganization 37057894 1 19 0 -RIPK2 RIPK2 EC 2.7.10.2; EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, Ser/Thr (non-receptor); Protein kinase, TKL; Protein kinase, tyrosine (non-receptor) O43353 8767 8q21.3 human K209-ub 2793000 QKSRASIkHDIYSYA PK_Tyr_Ser-Thr molecular association, regulation signaling pathway regulation TAK1(INDUCES); TAB2(INDUCES); XIAP(DISRUPTS); TAB1(INDUCES); IKKG(INDUCES) 18079694; 32954645 3 1 0 mutagenesis of K209 blocks RIPK2 ubiquitination and inflammatory signaling by displacing XIAP; authors did not detect ubiquitination of RIPK2 K209 during NOD2 signaling; regulation Nod1-Nod2 and RIPK2 polyubiquitylation-mediated NF-kB activation and secretion of chemokines -Cacna1a CACNA1A Channel, calcium; Membrane protein, integral; Membrane protein, multi-pass P97445 12286 8 C2|8 40.95 cM mouse S2361-p 4713048 RGAHDAYsESEDDWC activity, induced 32630015 1 4 0 regulates Ca2+ entry and insulin secretion in pancreatic-beta cells -Bmf BMF Apoptosis; Cytoskeletal Q91ZE9 171543 2|2 E5 mouse S74-p 11267001 DKATQTLsPASPSQG BMF activity, induced apoptosis, altered; apoptosis, induced 19841067; 29141222 5 0 0 partially contributes to anoikis; required for normal lymphocyte homeostasis -RAPH1 RAPH1 Adaptor/scaffold; Motility/polarity/chemotaxis Q70E73 65059 2q33.2 human S1069-p 1883958000 VEFPSPPsDSDFPPP intracellular localization cell motility, induced VASP(DISRUPTS) 37632751 1 1 0 regulates MENA localization -Rps6kb1 p70S6K EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, AGC; Protein kinase, Ser/Thr (non-receptor); Translation P67999 83840 10q26 rat S40-p 450117 DQPEDAGsEDELEEG molecular association, regulation Exportin-1(INDUCES) 16895915 2 1 6 -PPP2CA PPP2CA EC 3.1.3.16; Motility/polarity/chemotaxis; PHOSPHATASE; Protein phosphatase, Ser/Thr (non-receptor) P67774 cow L309-me 3627520 RRTPDYFl_______ enzymatic activity, induced 26569399 10 0 0 -Ntrk3 TrkC EC 2.7.10.1; KINASE; Kinase, protein; Membrane protein, integral; Protein kinase, TK; Protein kinase, tyrosine (receptor) Q03351 29613 1q31 rat Y859-p 451749 LGKATPIyLDILG__ molecular association, regulation PLCG1(INDUCES); SHC1(INDUCES) 7657612 2 0 0 -ZNF76 ZNF76 C2H2-type zinc finger protein P36508 7629 6p21.31 human K411-sm 2798302 IAYLSEVkEERDDIP molecular association, regulation; activity, inhibited transcription, altered TBP(DISRUPTS) 15280358; 16337145 2 0 0 -H3C1 H3 DNA-binding P68431 8350 6p22.2 human K27-ac 465521 LATKAARkSAPATGG Histone acetylation; molecular association, regulation; intracellular localization cell differentiation, inhibited; cell cycle regulation; carcinogenesis, induced; carcinogenesis, inhibited; apoptosis, induced; transcription, induced; transcription, altered; DNA repair, induced; chromatin organization, altered; transcription, inhibited BRD4(INDUCES); TIF1G(INDUCES) DNA(INDUCES); DNA(DISRUPTS) 20385584; 20720004; 21282660; 21726812; 23287868; 25941994; 26286207; 28630323; 28671020; 28716899; 28751304; 28953875; 32079144; 35222362; 35792897; 36060800; 37638746 74 18 13 -EGFR EGFR EC 2.7.10.1; KINASE; Kinase, protein; Membrane protein, integral; Oncoprotein; Protein kinase, TK; Protein kinase, tyrosine (receptor) P00533 1956 7p11.2 human K823-ub 1065314 NWCVQIAkGMNYLED PK_Tyr_Ser-Thr protein degradation 17940017 1 1 0 -SKP2 SKP2 Cell cycle regulation; UBIQUITIN LIGASE; Ubiquitin conjugating system; Ubiquitin ligase Q13309 6502 5p13.2 human S64-p 457412 SNLGHPEsPPRKRLK activity, induced; protein stabilization; molecular association, regulation; ubiquitination; phosphorylation cell cycle regulation; carcinogenesis, induced; cell growth, induced; transcription, induced CDH1(DISRUPTS); NKX3-1(INDUCES) 18239684; 20663873; 27065334; 33793628 6 28 2 -Llgl1 LLGL1 Cell adhesion; Cytoskeletal; Motility/polarity/chemotaxis Q80Y17 16897 11 B2|11 37.81 cM mouse S658-p 449916 RVKSLKKsLRQSFRR intracellular localization 11809830 2 10 7 -Mknk1 Mnk1 EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, CAMK; Protein kinase, Ser/Thr (non-receptor); Translation O08605 17346 4|4 D1 mouse T214-p 447622 ITTPELTtPCGSAEY Pkinase molecular association, regulation; enzymatic activity, induced eIF4G(INDUCES) 10022874 13 1 0 -GFAP GFAP Cytoskeletal P14136 2670 17q21.31 human S8-p 449618 MERRRITsAARRSYV Filament_head molecular association, regulation; protein stabilization fascin(INDUCES) 12177195; 19170683 9 0 0 -ITSN1 ITSN1 Adaptor/scaffold; Calcium-binding; GEF; GEF, Rac/Rho Q15811 6453 21q22.11 human T832-p 280867300 PKLALREtPAPLAVT INTAP molecular association, regulation; intracellular localization SYN1(INDUCES) 29078407 1 0 0 presynaptic nanoscale distribution of synapsin I -LIMA1 eplin Actin-binding; Cytoskeletal; Motility/polarity/chemotaxis Q9UHB6 51474 12q13.12 human S604-p 459750 FQSTSVKsPKTVSPP protein degradation; ubiquitination carcinogenesis, induced; cell adhesion, induced; cytoskeletal reorganization; cell motility, inhibited 23188829; 28465438 3 29 16 E-cadherin down regulation, EMT; formation of large plasma membrane ruffles that are characterized by highly dynamic actin rearrangements in their lamellipodia -HNRNPUL1 E1B-AP5 RNA splicing; RNA-binding Q9BUJ2 11100 19q13.2 human R645-m2 15381101 NRGGFQNrGGGSGGG molecular association, regulation; intracellular localization NBS1(INDUCES) 26020839 1 2 14 ecruitment at sites of damage -FERMT2 kindlin-2 Cytoskeletal; Motility/polarity/chemotaxis Q96AC1 10979 14q22.1 human S181-p 3208614 GSGSIYSsPGLYSKT protein degradation; molecular association, regulation; ubiquitination cell cycle regulation; cell growth, induced; apoptosis, inhibited; cytoskeletal reorganization; cell adhesion, inhibited CUL9(INDUCES) 25646088; 35469017 2 3 4 -NRF1 NRF1 DNA-binding; Transcription factor Q16656 4899 7q32.2 human K230-ub 1878066500 GWGKESCkPIWWPED protein degradation carcinogenesis, induced; cell growth, induced; transcription, altered 30833558 1 0 0 under hypoxia -Hspa1a HSP70 Chaperone; Heat shock protein; Motility/polarity/chemotaxis Q61696 193740 17 B1|17 18.51 cM mouse R416-me 1877047301 VMTALIKrNSTIPTK HSP70 protein stabilization carcinogenesis, induced; cell growth, induced; apoptosis, inhibited RNA(INDUCES) 32699135 1 1 0 binding and stabilization of BCL2 mRNA -NSD2 WHSC1 Amino Acid Metabolism - lysine degradation; EC 2.1.1.43; METHYLTRANSFERASE; Methyltransferase; Methyltransferase, protein lysine; Oncoprotein; Ubiquitin conjugating system O96028 7468 4p16.3 human S172-p 478693 ARRNRKRsIKYDSLL protein stabilization cell motility, inhibited CUL4B(DISRUPTS) 28319045 1 7 50 prostate cancer metastasis -FOXM1 FOXM1 DNA-binding; Transcription factor Q08050 2305 12p13.33 human K422-ac 57807002 KRVRIAPkVLLAEEG activity, induced; protein stabilization; molecular association, regulation; phosphorylation carcinogenesis, induced; cell growth, induced; transcription, induced DNA(NOT_REPORTED) 27542221 1 1 0 -SPRED2 SPRED2 Motility/polarity/chemotaxis; Vesicle Q7Z698 200734 2p14 human Y231-p 471404 WMTGYEDyRHAPVRG protein degradation 17094949 1 1 7 Pervanadate induced Spred-2 degredation in ME4405 cells which is dependent on ubiquitination. -Ms4a2 FcER1B Membrane protein, integral; Membrane protein, multi-pass; Receptor, misc. P13386 25316 1q43 rat Y228-p 2883702 LHVYSPIySALEDTR molecular association, regulation GRB2(INDUCES); SHIP(INDUCES); Syk(INDUCES); SHC1(INDUCES); SHP-1(INDUCES) 17365510 1 1 0 SHIP binding is senstive to the presence of Syk. -PDCD5 PDCD5 Apoptosis O14737 9141 19q13.11 human K98-ub 3934349 GLIEILKkVSQQTEK dsDNA_bind protein degradation apoptosis, inhibited 25499082 1 2 8 -Gap43 GAP43 Cell surface P07936 29423 11q21 rat S41-p 448719 AATKIQAsFRGHITR IQ cytoskeletal reorganization; cell adhesion, altered; cell growth, altered 19249369 14 9 5 binds and stabilizes F-actin filaments -Irf3 IRF3 DNA-binding; Transcription factor P70671 54131 7|7 B3 mouse S378-p 448696 MAREGGAsSLKTVDL transcription, induced; signaling pathway regulation 33710283; 33976210; 35082159 12 3 0 -TP53BP2 53BP2 Transcription, coactivator/corepressor Q13625 7159 1q41 human Y874-p 36747001 PPYPPPPyPSGEPEG protein degradation; molecular association, regulation; intracellular localization; phosphorylation transcription, induced 53BP2(INDUCES) 25360797 1 0 0 promotes the dephosphorylation of YAP -PIP5K1B PIP5K1B Carbohydrate Metabolism - inositol phosphate; EC 2.7.1.68; Kinase, lipid O14986 8395 9q21.11 human Y105-p 9471801 FGIKPDDyLYSICSE intracellular localization; enzymatic activity, inhibited cytoskeletal reorganization 19553680 1 0 0 -PTGES3 TEBP Chaperone; EC 5.3.99.3; Isomerase; Nuclear receptor co-regulator; Transferase Q15185 10728 12q13.3|12 human S118-p 451130 DDSDEDMsNFDRFSE molecular association, regulation; enzymatic activity, induced HSP90A(INDUCES); CK2A1(INDUCES) 15040786 1 18 3 -KIT Kit EC 2.7.10.1; KINASE; Kinase, protein; Membrane protein, integral; Oncoprotein; Protein kinase, TK; Protein kinase, tyrosine (receptor) P10721 3815 4q12 human Y721-p 448017 CSDSTNEyMDMKPGV PK_Tyr_Ser-Thr activity, induced cell adhesion, altered 15654360; 21887372 18 5 52 -Pard3 PAR3-alpha Adaptor/scaffold; Motility/polarity/chemotaxis Q9Z340 81918 19q12 rat S1116-p 28758704 ALNARPQsPREGHLM molecular association, regulation; intracellular localization cytoskeletal reorganization KIF3A(DISRUPTS) 23946386 1 3 0 S1116-p inhibits transport of Par3 toward the distal part of axon and regulates polarity. -KCNH2 Kv11.1 Channel, potassium; Membrane protein, integral; Membrane protein, multi-pass; Motility/polarity/chemotaxis Q12809 3757 7q36.1 human T895-p 4974500 KLSFRRRtDKDTEQP activity, inhibited signaling pathway regulation 10488078; 10837251; 18791070 4 0 1 -ARPP19 ARPP-19 Cell cycle regulation; Phosphatase, regulatory subunit P56211 10776 15q21.2 human S62-p 465742 KGQKYFDsGDYNMAK Endosulfine molecular association, regulation; enzymatic activity, inhibited cell cycle regulation PPP2CA(INDUCES) 30626720; 32085646 3 70 47 -DICER1 DICER1 Cell development/differentiation; EC 3.1.26.3; Helicase; RNA processing; RNA-binding; Ribonuclease Q9UPY3 23405 14q32.13 human S1728-p 114810400 YEDPRQHsPGVLTDL Ribonuclease_3 DNA repair, induced 28642363 1 1 0 -ANTXR2 ANTXR2 Membrane protein, integral; Receptor, misc. P58335 118429 4q21.21 human Y381-p 3697372 PTVDASYyGGRGVGG ubiquitination 20080640 1 4 42 -Il3ra IL3RA Membrane protein, integral P26952 16188 14 A1|14 7.08 cM mouse K357-ub 1877015603 GLLLWWRkSLLYRLC protein degradation 31990690 2 0 0 lung innate immunity and in?ammation in vivo -BCL3 Bcl-3 Apoptosis; Nuclear receptor co-regulator; Oncoprotein; Transcription regulation P20749 602 19q13.32 human S122-p 143278600 CPMEHPLsADIAMAT cell motility, induced; transcription, induced 28689659 1 1 0 -Ptk2 FAK iso2 EC 2.7.10.2; KINASE; Kinase, protein; Protein kinase, TK; Protein kinase, tyrosine (non-receptor) P34152-2 14083 15 D3|15 33.94 cM mouse Y956-p 447966 DRSNDKVyENVTGLV Focal_AT molecular association, regulation; enzymatic activity, induced; phosphorylation cell motility, altered; cytoskeletal reorganization; cell adhesion, altered; cell growth, altered PXN(DISRUPTS); PXN(INDUCES) 18606490; 20159040 104 17 427 regulates VEGF expression and ERK phosphorylation; axon remodeling, disassembly from paxillin -Gria1 GluR1 Channel, calcium; Channel, ligand-gated; Membrane protein, integral; Membrane protein, multi-pass P23818 14799 11 B1.3|11 34.51 cM mouse K886-ub 40320201 VVSQDFPkSMQSIPC protein degradation; receptor internalization, inhibited 28212375 3 0 0 regulation of Nedd4-2 mediated spontaneous neuronal activity and seizure susceptibility -LALBA LALBA Apoptosis; Secreted; Secreted, signal peptide; Transferase P00711 281894 cow S41-p 1875112300 LKGYGGVsLPEWVCT Lys molecular association, regulation; protein conformation IGE(DISRUPTS); IgG(DISRUPTS) 34655828 0 1 0 -TERT TERT iso3 DNA-binding; EC 2.7.7.49; Nucleolus; Transferase O14746-3 7015 5p15.33 human K94-ub 14561000 RLCERGAkNVLAFGF protein degradation chromatin organization, altered; apoptosis, induced 20453884 1 0 0 -Gab2 GAB2 Adaptor/scaffold Q9Z1S8 14389 7|7 E1 mouse Y632-p 450913 TSDEKVDyVQVDKEK molecular association, regulation cell differentiation, altered; cell growth, altered SHP-2(INDUCES) 11287610 4 11 190 -FRAT1 FRAT1 Oncoprotein; Transcription regulation Q92837 10023 10q24.1 human S188-p 471366 RLQQRRGsQPETRTG GSK-3_bind protein degradation; activity, inhibited transcription, inhibited 16982607 1 0 0 phosphorylation of this site inhibits FRAT1 activity (towards GSK3beta) and reduces its ability to activate beta catenin-TCF/LEF-dependent transcription -LAX1 LAX1 Adaptor/scaffold; Membrane protein, integral Q8IWV1 54900 1q32.1 human Y193-p 35546000 SSEDSHDyVNVPTAE LAX molecular association, regulation transcription, inhibited; signaling pathway regulation GRB2(INDUCES); GADS(INDUCES); PIK3R1(INDUCES) 12359715 1 0 0 -Nr3c1 GR DNA-binding; Mitochondrial; Nuclear receptor; Transcription factor P06537 14815 18 B3|18 21.09 cM mouse K435-ub 485771 TATGPPPkLCLVCSD zf-C4 protein degradation transcription, inhibited 11555652 1 0 0 -DDB2 DDB2 DNA repair, damage Q92466 1643 11p11.2 human K77-ac 1876931103 VRTLHQHkLGRASWP DNA repair, induced 32789493 1 1 0 SIRT6 as a critical factor in the regulation of the process of UV-induced DNA damage repair -Prkca PKCA EC 2.7.11.13; KINASE; Kinase, protein; Oncoprotein; Protein kinase, AGC; Protein kinase, Ser/Thr (non-receptor) P05696 24680 10q32.1 rat S657-p 448597 QSDFEGFsYVNPQFV Pkinase_C signaling pathway regulation 23490331 28 4 2 diabetes-type1 and type2-related signaling in brain -MME CD10 EC 3.4.24.11; Membrane protein, integral; Protease P08473 4311 3q25.2 human S6-p 3850156 __MGKSEsQMDITDI protein stabilization; molecular association, regulation; intracellular localization; phosphorylation PTEN(DISRUPTS) 20957047; 22767595 2 14 19 regulates cell surface neprilysin localization and A? stability; phosphorylation of this site (MME S6D mutant) increases insulin/IGF-1 stimulated activation of Akt -TOP2A TOP2A EC 5.99.1.3; Isomerase P11388 7153 17q21.2 human S1361-p 455094 SPPKTKTsPKLSNKE protein degradation; molecular association, regulation; ubiquitination FBXW7(INDUCES) 21254166 2 1 0 -LIFR LIFR Membrane protein, integral; Receptor, cytokine P42702 3977 5p13.1 human K880-ac 62856002 IPNPENCkALQFQKS protein conformation 28122243 1 1 0 ESC pluripotency in vivo -TP53BP1 53BP1 DNA repair, damage; Transcription, coactivator/corepressor Q12888 7158 15q15.3 human R1400-me 2344820 VTPRGRGrRGRPPSR molecular association, regulation DNA(INDUCES) 16294045 2 0 0 -Upf1 RENT1 C2H2-type zinc finger protein; EC 3.6.1.-; EC 3.6.4.-; Hydrolase; RNA-binding Q9EPU0 19704 8 B3.3|8 34.15 cM mouse T28-p 21560213 AELLGADtQGSEFEF molecular association, regulation; phosphorylation; enzymatic activity, induced RNA splicing, induced; RNA stability, inhibited; translation, induced; signaling pathway regulation MCPIP1(INDUCES) 31329944 3 0 0 Regnase mRNA decay induced by phosphorylation of RENT1-T28, Regnase-1 deficiency upregulates target mRNAs at the pioneer round of translation. SMG1-Regnase-1 pathway -CDCA5 CDCA5 Cell cycle regulation Q96FF9 113130 11q13.1 human S33-p 472118 LRRSQRKsGSELPSI activity, inhibited cell cycle regulation SCC-112(DISRUPTS) 23901111 1 8 2 -Mapk7 ERK5 EC 2.7.11.24; KINASE; Kinase, protein; Protein kinase, CMGC; Protein kinase, Ser/Thr (non-receptor) Q9WVS8 23939 11|11 B2 mouse S764-p 14561006 QADSASLsASLLADW transcription, altered 17928297 2 1 0 -H3C1 H3 DNA-binding P68431 8350 6p22.2 human K79-m2 1458615 REIAQDFkTDLRFQS Histone protein stabilization; molecular association, regulation; methylation; protein conformation carcinogenesis, induced; carcinogenesis, inhibited; cell growth, induced; chromatin organization, altered; transcription, induced; transcription, altered; transcription, inhibited L3MBTL iso4(INDUCES); DOT1L(INDUCES); 53BP1(INDUCES) 17190600; 18794842; 18977325; 19734945; 19805358; 20348416; 23361907; 23412334; 23583077; 31727944; 35172132 40 21 10 ubiquitin and nucleosome acidic patch binding by DOT1L are required for cell proliferation in a leukemia model; regulation genes that control the host-response against infection which can be modulated by Pinometostat -Notch1 Notch 1 Membrane protein, integral; Motility/polarity/chemotaxis; Oncoprotein; Receptor, misc.; Transcription factor Q01705 18128 2 A3|2 18.91 cM mouse K2161-ac 18899507 KGLACGSkEAKDLKA protein stabilization; ubiquitination 21499261 1 2 0 -Kif11 KIF11 Microtubule-binding; Motor F1MAB8 rat T926-p 448410 LDIPTGMtPERKNYL Microtub_bind molecular association, regulation cytoskeletal reorganization TUBB3(INDUCES) 25355946 8 29 2 association with tyrosinated microtubules -SNRPB snRNP B1 RNA processing; RNA splicing; RNA-binding; Spliceosome P14678 6628 20p13 human R108-m2 476753 AGGPGIGrAAGRGIP molecular association, regulation SMN(INDUCES) 11720283 1 7 26 -FAF1 FAF1 Apoptosis; Nuclear receptor co-regulator Q9UNN5 11124 1p32.3 human S291-p 450287 DVHMVSDsDGDDFED intracellular localization cell cycle regulation 12832043; 18790738; 27662363 3 2 0 mediates the proteasome-dependent degradation of AurA; nuclear localization; induces G2/M arrest -Cttn Cortactin Actin-binding; Cytoskeletal; Motility/polarity/chemotaxis Q60598 13043 7|7 F5 mouse K193-ac 1880005101 ESQKDYSkGFGGKYG molecular association, regulation; acetylation; intracellular localization DIP2A(INDUCES) 31600191 1 0 0 DIP2A regulates spine morphology and synaptic transmission through acetylation of cortactin; Interaction of DIP2A-cortactin is required for acetylated cortactin; acetylation mimetic cortactin rescues the repetitive behaviors in Dip2a KO mice; acetylation alleviated abnormal PSD95 clustering at the spine head in DIP2A KO neurons -KCNJ11 Kir6.2 Channel, potassium; Membrane protein, integral; Membrane protein, multi-pass Q14654 3767 11p15.1 human T180-p 450652 QAHRRAEtLIFSKHA receptor internalization, induced 23223335 2 0 0 -CIB1 CIB1 Cell adhesion; Motility/polarity/chemotaxis Q99828 10519 15q26.1 human K10-ub 21171746 GSGSRLSkELLAEYQ protein degradation cell motility, inhibited 33082516 1 6 0 -IRS1 IRS1 Adaptor/scaffold; Motility/polarity/chemotaxis P35568 3667 2q36.3 human S24-p 455604 GYLRKPKsMHKRFFV PH molecular association, regulation PIK3C2A(INDUCES); INSR(INDUCES) 15849359 2 2 0 -Trim28 TIF1B EC 6.3.2.-; KINASE; Kinase, protein; Ligase; Nuclear receptor co-regulator; Protein kinase, atypical; SUMO LIGASE; SUMO ligase; Transcription, coactivator/corepressor; UBIQUITIN LIGASE; Ubiquitin conjugating system; Ubiquitin ligase Q62318 21849 7|7 A1 mouse K750-sm 3142606 IRARLQEkLSPPYSS transcription, inhibited 17298944 2 8 0 -SLC22A6 SLC22A6 Membrane protein, integral; Membrane protein, multi-pass; Transporter; Transporter, SLC family Q4U2R8 9356 11q12.3 human K297-ub 53529106 RVARINGkREEGAKL Sugar_tr receptor internalization, induced 23640180 1 0 0 -Gys2 GYS2 Carbohydrate Metabolism - starch and sucrose; Cytoskeletal; EC 2.4.1.11; Transferase P17625 25623 4q44 rat S8-p 484503 MLRGRSLsVTSLGGL intracellular localization; enzymatic activity, inhibited 19124463 1 8 0 translocation dependent on glycogen synthesis -AIP AIP Nuclear receptor co-regulator; Transcription, coactivator/corepressor O00170 9049 11q13.2 human S131-p 10888701 VAQMREHsSLGHADL molecular association, regulation HSP90A(INDUCES) 12361709 2 0 0 -TP53BP1 53BP1 DNA repair, damage; Transcription, coactivator/corepressor Q12888 7158 15q15.3 human S1342-p 3194873 GPLRGKTsGTEPADF intracellular localization 28415769 1 5 1 recruitment at kinetochores during mitosis -RORA RORA DNA-binding; Nuclear receptor P35398 6095 15q22.2 human K240-sm 6124702 GLDINGIkPEPICDY transcription, induced 19041634 1 0 0 -MAPT Tau iso8 ACETYLTRANSFERASE; Acetyltransferase; Cytoskeletal P10636-8 4137 17q21.31 human S202-p 447928 SGYSSPGsPGTPGSR O-GlcNAc glycosylation; molecular association, regulation; intracellular localization; protein conformation; phosphorylation cytoskeletal reorganization ubiquitin(INDUCES); Fyn(DISRUPTS); Tau iso8(INDUCES); CRMP-2(INDUCES); Tau(INDUCES) 12414518; 14761950; 15190058; 15364924; 15664690; 16115884; 16923168; 18725412; 19451179; 20550628; 24312574; 26161867; 28758999; 31543505; 32019603; 33952699; 35610289; 37488165 175 57 116 -EPRS1 EPRS Aminoacyl-tRNA synthetase; Cofactor and Vitamin Metabolism - porphyrin and chlorophyll; EC 6.1.1.15; EC 6.1.1.17; Ligase; Translation; Translation regulation P07814 2058 1q41 human S990-p 58109406 DGQRKDPsKNQGGGL molecular association, regulation hnRNP E2(INDUCES) 27595231 1 1 0 dissociation multi-tRNA synthetase complex (MSC) ; blocked PCBP2-mediated ubiquitination of MAVS -MAGI1 MAGI1 Cell adhesion; Motility/polarity/chemotaxis Q96QZ7 9223 3p14.1 human K931-sm 1871464502 KVVFAVPkTENEVPS signaling pathway regulation 33304925 2 0 0 K931 sumoylation prevents localization and stabilizes the barrier; p90RSK-mediated MAGI1 PTMs and the Hippo pathway signaling -SLN sarcolipin Endoplasmic reticulum; Membrane protein, integral O00631 6588 11q22.3 human T5-p 459214 ___MGINtRELFLNF Sarcolipin molecular association, regulation; protein conformation ATP2A1(DISRUPTS) 23455424; 27378083; 32668157 6 0 0 Decrease correlation between N-Terminal and C-Terminal domains; in vitro; Pentameric phospho-SLN promotes penetration of monovalent and divalent ions through the channel. -HSF1 HSF1 DNA-binding; Transcription factor Q00613 3297 8q24.3 human K298-sm 3656302 SSPLVRVkEEPPSPP Vert_HS_TF sumoylation; molecular association, regulation; intracellular localization transcription, inhibited DNA(INDUCES) 11514557; 16371476; 19597476 7 1 0 -FYB1 SLAP-130 Adaptor/scaffold O15117 2533 5p13.1 human Y771-p 449430 ADNDGEIyDDIADGC hSH3 molecular association, regulation cell adhesion, induced; cell motility, altered; cell adhesion, altered SLP76(INDUCES) 20661443; 23979596 4 3 68 -Plin5 perilipin 5 Q8BVZ1 66968 17|17 D mouse S155-p 8095494 AQRGRRWsGELRRSM Perilipin molecular association, regulation; intracellular localization ABHD5(DISRUPTS); PNPLA2(INDUCES) 28919478; 33334871 3 8 1 regulation of lipolysis and fatty acid beta-oxidation; important for PKA-dependent lipolysis; regulation of glycemic control -PPP3CB PPP3CB EC 3.1.3.16; PHOSPHATASE; Protein phosphatase, Ser/Thr (non-receptor) P16298 5532 10q22.2 human K327-ub 1878212800 YLDVYNNkAAVLKYE cell cycle regulation; cell growth, inhibited; transcription, inhibited 31135381 1 1 0 USP16 regulates T cell proliferation and cell-cycle entry; Ubiquitination of PPP3CB impairs NFAT recruitment and transcription of NFAT-targeted genes -Nfkb1 NFkB-p105 DNA-binding; Transcription factor P25799 18033 3 G3|3 62.82 cM mouse S240-p 34354490 VSDAIYDsKAPNASN RHD_DNA_bind molecular association, regulation; protein conformation transcription, altered DNA(DISRUPTS) 29873020 1 1 1 -SH3BP2 SH3BP2 Adaptor/scaffold P78314 6452 4p16.3 human S225-p 455469 SDMPRAHsFTSKGPG molecular association, regulation 14-3-3 theta(INDUCES) 12501243 1 9 0 -PTEN PTEN iso2 Carbohydrate Metabolism - inositol phosphate; EC 3.1.3.16; EC 3.1.3.48; EC 3.1.3.67; Motility/polarity/chemotaxis; Nuclear receptor co-regulator; PHOSPHATASE; Phosphatase, lipid; Tumor suppressor P60484-2 5728 10q23.31 human K239-ub 27205468 SKHKNHYkIYNLCAE protein degradation 31685992 3 3 0 -G6PD G6PD Carbohydrate Metabolism - pentose phosphate pathway; Cell development/differentiation; EC 1.1.1.49; Other Amino Acids Metabolism - glutathione; Oxidoreductase P11413 2539 Xq28 human K408-ac 33364576 YTKMMTKkPGMFFNP G6PD_C enzymatic activity, altered 37798264 1 3 0 -Mapk9 JNK2 EC 2.7.11.24; KINASE; Kinase, protein; Protein kinase, CMGC; Protein kinase, Ser/Thr (non-receptor) Q9WTU6 26420 11|11 B1.2-B1.3 mouse Y185-p 447652 TNFMMTPyVVTRYYR Pkinase enzymatic activity, induced apoptosis, induced; cell motility, induced; transcription, inhibited 16061178; 18032450; 26306048 75 39 1441 GTS sequence motif within the activation loop offers a higher phosphorylation efficiency and therefore functional activation of JNK1 over JNK2.; Fyn and thapsigargin-induced cell death; transcription leading to gene expression, epithelial cell migration and eyelid closure. -Cttn Cortactin Actin-binding; Cytoskeletal; Motility/polarity/chemotaxis Q60598 13043 7|7 F5 mouse S405-p 447700 KKQTPPAsPSPQPIE cell cycle regulation; cell motility, altered 18515860 18 87 128 -KCND2 Kv4.2 Channel, potassium; Membrane protein, integral; Membrane protein, multi-pass Q9NZV8 3751 7q31.31 human S552-p 450462 VSGSHQGsIQELSTI protein stabilization; intracellular localization 20045463 6 8 0 KCNIP4-mediated enhancement of channel surface expression -Brsk2 BRSK2 EC 2.7.11.1; EC 2.7.11.26; KINASE; Kinase, protein; Protein kinase, CAMK; Protein kinase, Ser/Thr (non-receptor) Q69Z98 75770 7|7 F5 mouse T444-p 17551641 PRGSPLPtPKGTPVH protein stabilization; enzymatic activity, inhibited; phosphorylation 23790753 2 2 0 inhibits axon branching (activated in BRSK2 18A mutant) -FAAP20 FAAP20 iso2 Q6NZ36 199990 1p36.33 human S48-p 1868139203 AELLRTVsPELILDH FANCA_interact protein stabilization; molecular association, regulation; protein conformation signaling pathway regulation PIN1(INDUCES) 30789902 1 1 0 PIN1 interaction regulate the FBW7 proteolytic signaling ; isomerization of pFAAP20 by PIN1 -PSEN1 PSEN1 Cell surface; EC 3.4.23.-; Membrane protein, integral; Membrane protein, multi-pass; Mitochondrial; Protease P49768 5663 14q24.2 human T320-p 3397302 SKYNAEStERESQDT Presenilin protein stabilization; enzymatic activity, induced 18667537 1 0 0 -Gabrb1 GABRB1 Channel, chloride; Channel, ligand-gated; Membrane protein, integral; Membrane protein, multi-pass; Transporter; Transporter, ion channel P50571 14400 5 C3.2|5 38.18 cM mouse S410-p 10296601 QYRKPLSsREGFGRG Neur_chan_memb activity, induced 10195104 1 0 0 -DLG4 PSD-95 Adaptor/scaffold P78352 1742 17p13.1 human S295-p 456936 PTSPRRYsPVAKDLL PDZ_assoc neural plasticity 34665640 4 12 0 -PRKCD PKCD EC 2.7.11.13; KINASE; Kinase, protein; Nuclear receptor co-regulator; Protein kinase, AGC; Protein kinase, Ser/Thr (non-receptor); Protein kinase, tyrosine (non-receptor); Tumor suppressor Q05655 5580 3p21.1 human S645-p 448591 LNEKARLsYSDKNLI Pkinase_C sumoylation; intracellular localization carcinogenesis, induced 28237688; 34089566; 34155348 29 51 79 -MARCHF5 MARCH5 EC 6.3.2.-; EC 6.3.2.19; Ligase; Membrane protein, integral; Membrane protein, multi-pass; UBIQUITIN LIGASE; Ubiquitin conjugating system; Ubiquitin ligase Q9NX47 54708 10q23.32-q23.33 human K268-ub 15392450 YLRQAHRkILNYPEQ intracellular localization autophagy, induced 31602805 1 2 1 MARCH5 is required for MITOL relocation to peroxisomes -USF1 USF1 DNA-binding; Transcription factor P22415 7391 1q23.3 human K235-ac 7378203 DCSMESTkSGQSKGG HLH molecular association, regulation; intracellular localization transcription, induced SMARCD3(INDUCES) 23219531 2 1 0 K235 acetylation induces recruitment of SMARCD3 to the promoters of lipogenic genes -Rab13 RAB13 G protein; G protein, monomeric; G protein, monomeric, Rab Q9DD03 68328 3 F1|3 39.21 cM mouse K58-ub 964538718 DIEGKRIkLQVWDTA Ras molecular association, regulation GDI1(DISRUPTS) 35343654 1 1 0 Promotes the Post-Golgi Tra?cking of TLR4 and TLR9 -CERT1 COL4A3BP EC 2.7.11.9; KINASE; Kinase, protein; Lipid-binding; Protein kinase, Ser/Thr (non-receptor); Protein kinase, atypical Q9Y5P4 10087 5q13.3 human S135-p 4777474 RRHGSMVsLVSGASG molecular association, regulation; intracellular localization; activity, inhibited 28652409; 33347465 1 7 1 reduced PtdIns(4)P binding affinity as well as low ceramide transfer activity, E494R/N495K/P535R/E537K mutations, recovery of both PtdIns(4)P binding and ceramide transfer activity.; Regulates de novo SM synthesis -KNSTRN TRAF4AF1 Q9Y448 90417 15q15.1 human Y87-p 3583497 TSVVKTVySLQPPSA intracellular localization 33510346 1 1 2 -AURKB AurB EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, Other; Protein kinase, Ser/Thr (non-receptor) Q96GD4 9212 17p13.1 human K87-sm 25087010 GRPLGKGkFGNVYLA Pkinase phosphorylation; enzymatic activity, induced 21554500 1 0 0 induces phosphorylation at T232 -Deaf1 DEAF1 Motility/polarity/chemotaxis; Transcription, coactivator/corepressor Q9Z1T5 54006 7|7 F5 mouse T435-p 34734306 AVPPSTPtKAVSPTV protein stabilization; molecular association, regulation LMO4(INDUCES) 25310299 1 0 1 -LEPR LEPR Membrane protein, integral; Receptor, cytokine P48357 3953 1p31.3 human Y1079-p 451292 NDKKSIYyLGVTSIK activity, induced transcription, induced 17726024 7 0 0 -NFATC1 NFAT2 DNA-binding; Transcription factor O95644 4772 18q23 human K349-sm 6413903 QPPSVALkVEPVGED molecular association, regulation; intracellular localization chromatin organization, altered; transcription, inhibited HDAC1(INDUCES); HDAC2(INDUCES); PML(INDUCES); HDAC4(INDUCES) 19218564 3 1 0 -Elk3 ELK3 DNA-binding; Transcription factor P41971 13713 10 C2|10 48.04 cM mouse S359-p 450031 IHFWSSLsPVAPLSP activity, induced; intracellular localization transcription, altered; cell growth, altered 11042694; 18356083 2 0 0 pro-B cell expansion -Npr2 ANPB EC 4.6.1.2; Guanylyl cyclase; KINASE; Kinase, protein; Lyase; Membrane protein, integral; Nucleotide Metabolism - purine; Protein kinase, RGC; Protein kinase, dual-specificity (receptor); Receptor, misc. P16067 116564 5q22 rat S489-p 25528502 MLEKELAsMLWRIRW enzymatic activity, induced 22590601 1 0 0 -PSRC1 PSRC1 Q6PGN9 84722 1p13.3 human S225-p 18963102 AKLRVSGsGEFVGLT cytoskeletal reorganization 21473853 1 1 0 -Shtn1 SHOT1 Unknown function A0MZ67 292139 1q55 rat S249-p 485709 QNKLKRQsHLLLQSS molecular association, regulation; intracellular localization cell motility, induced; cytoskeletal reorganization Cortactin(INDUCES) 23453953; 26261183 4 19 4 SHOT1 phosphorylation increases binding affinity with F-Actin and induces axonal outgrowth; signal?force transduction in axon outgrowth -TP63 p63 DNA-binding; Transcription factor Q9H3D4 8626 3q28 human S51-p 28802100 TQTNEFLsPEVFQHI molecular association, regulation apoptosis, altered; transcription, altered; transcription, inhibited p300(DISRUPTS); PIN1(INDUCES) 23589370; 33548094 2 1 0 -Etv4 ETV4 DNA-binding P28322 18612 11 D|11 65.48 cM mouse K95-ac 26373300 HSPTTRIkKEPQSPR ETS_PEA3_N sumoylation transcription, induced 21543453 1 1 0 acetylated sites inhibits sumoylation reciprocally -HHEX HHEX DNA-binding; Transcription factor Q03014 3087 10q23.33 human S163-p 7430500 FETQKYLsPPERKRL Homeodomain molecular association, regulation transcription, induced DNA(INDUCES) 19324893 2 2 1 -TIAM1 TIAM1 GEF; GEF, Rac/Rho; Motility/polarity/chemotaxis; Oncoprotein Q13009 7074 21q22.11 human S329-p 23152631 DVNAGEGsEFADSGI protein degradation; molecular association, regulation BTRC(INDUCES) 25124033 1 1 2 -Kcnb1 Kv2.1 Channel, cation; Channel, ligand-gated; Channel, potassium; Membrane protein, integral; Membrane protein, multi-pass Q03717 16500 2 H3|2 87.22 cM mouse S804-p 473562 ESSPLPTsPKFLRPN apoptosis, induced 33333928 8 8 0 -FOXN3 FOXN3 DNA-binding; Transcription factor O00409 1112 14q31.3-q32.11 human S83-p 4930951 FGESVLRsVSPVQDL activity, induced; protein degradation; molecular association, regulation; ubiquitination signaling pathway regulation hnRNP U(DISRUPTS) 36794705 1 4 2 induces NFKB activity and signaling -Grin2a NMDAR2A Channel, ligand-gated; Membrane protein, integral; Membrane protein, multi-pass Q00959 24409 10q11 rat S1048-p 36747000 NRTHSLKsPRYLPEE NMDAR2_C activity, induced; receptor internalization, inhibited 25368549 1 0 0 increases NMDAR2A gating -Add2 ADD2 Cytoskeletal; Motility/polarity/chemotaxis Q05764 24171 4q34 rat S606-p 3147414 TPASPVQsPTRAGTK cytoskeletal reorganization 21606488 1 15 0 -SLC9A1 NHE1 Membrane protein, integral; Membrane protein, multi-pass; Motility/polarity/chemotaxis; Transporter; Transporter, SLC family P19634 6548 1p36.11 human S771-p 475074 MRSKETSsPGTDDVF activity, induced; protein stabilization; protein conformation 17209041; 23602949; 23678047; 25162926 7 4 0 mutant expression decreased, defect in activation by sustained acidosis -GRB14 GRB14 Adaptor/scaffold Q14449 2888 2q24.3 human S358-p 31834913 MHPYQGRsGCSSQSI molecular association, regulation; phosphorylation INSR(DISRUPTS) 24535599; 28130417 2 2 0 -PPARGC1A PGC-1 alpha Nuclear receptor co-regulator; Transcription, coactivator/corepressor Q9UBK2 10891 4p15.2 human K347-ac 63355302 QGNNSTKkGPEQSEL transcription, inhibited 28340340 0 1 0 -LCK Lck EC 2.7.10.2; KINASE; Kinase, protein; Oncoprotein; Protein kinase, TK; Protein kinase, tyrosine (non-receptor) P06239 3932 1p35.2 human Y505-p 447823 FTATEGQyQPQP___ molecular association, regulation; intracellular localization; enzymatic activity, inhibited; activity, inhibited; protein conformation; phosphorylation cell growth, altered Lck(INDUCES) 10962552; 1639064; 17897955; 20541955; 2141684; 23202272; 2503711; 3352600; 34321230; 35638332; 36078131 57 32 805 -EEF1A2 EEF1A2 Translation; Translation elongation Q05639 1917 20q13.33 human S205-p 27930804 GDNMLEPsPNMPWFK GTP_EFTU protein degradation; molecular association, regulation 23608534 2 0 0 increased association with polysomes and newly synthesized polypeptides (NSPs) -ELF3 ELF3 DNA-binding; Motility/polarity/chemotaxis; Transcription factor P78545 1999 1q32.1 human S207-p 482811 GTGASRSsHSSDSGG protein stabilization; ubiquitination; phosphorylation transcription, induced; cell growth, altered 17491012 1 0 0 -NOS3 eNOS Amino Acid Metabolism - arginine and proline; EC 1.14.13.39; Oxidoreductase P29474 4846 7q36.1 human S1177-p 447884 TSRIRTQsFSLQERQ intracellular localization; enzymatic activity, induced cell differentiation, altered; cell differentiation, induced; cell motility, altered; transcription, induced; cytoskeletal reorganization; signaling pathway regulation 10376603; 11319202; 11402048; 11425855; 11978735; 12446767; 12511559; 12791703; 15136572; 15319357; 15728587; 16043647; 16270749; 18622039; 18718903; 21757745; 23768697; 26132171; 31923467; 32653904; 33539947; 33836561; 34026871; 34078530; 34204249; 34499618; 35559724; 35747946; 35817960; 35884891; 37336943 217 18 7 -SOS1 SOS1 Adaptor/scaffold; GEF; GEF, Ras; Motility/polarity/chemotaxis Q07889 6654 2p22.1 human S1197-p 451317 KAYSPRYsISDRTSI molecular association, regulation GRB2(DISRUPTS) 8816480 1 2 0 -Nfatc1 NFAT2 DNA-binding; Transcription factor O88942 18018 18 E3|18 53.66 cM mouse K351-ac 1876152500 HAPSVALkVEPAGED activity, induced; molecular association, regulation transcription, induced DNA(INDUCES) 21498542 1 0 0 -H2BC3 H2B DNA-binding P33778 3018 6p22.2 human K15-ac 458957 PAPKKGSkKAITKAQ Histone molecular association, regulation cell cycle regulation; carcinogenesis, induced; chromatin organization, altered; transcription, induced; transcription, altered polybromo 1(INDUCES) 16283522; 19883641; 20368734 8 9 468 -RAPH1 RAPH1 Adaptor/scaffold; Motility/polarity/chemotaxis Q70E73 65059 2q33.2 human T1123-p 1883958004 VKKAPPPtRPKRNDS intracellular localization cell motility, induced VASP(DISRUPTS) 37632751 1 1 0 regulates MENA localization -EZH2 EZH2 EC 2.1.1.43; METHYLTRANSFERASE; Methyltransferase; Methyltransferase, protein lysine Q15910 2146 7q36.1 human T487-p 452848 APAEDVDtPPRKKKR protein degradation; protein stabilization; molecular association, regulation; ubiquitination carcinogenesis, induced; cell motility, induced; cell growth, induced; apoptosis, inhibited; transcription, induced FOXM1(INDUCES); SUZ12(DISRUPTS); RACK7(INDUCES); EED(DISRUPTS) 21659531; 25800736; 27716745; 33593912; 35960849 14 59 66 -Kcnma1 KCNMA1 Channel, potassium; Endoplasmic reticulum; Membrane protein, integral; Membrane protein, multi-pass Q08460 16531 14|14 A3 mouse S938-p 469989 HGMLRQPsITTGVNI activity, induced 11244090 4 2 0 Channel activation is dependent on S938 phosphorylation. -Src Src EC 2.7.10.2; KINASE; Kinase, protein; Oncoprotein; Protein kinase, TK; Protein kinase, tyrosine (non-receptor) P05480 20779 2 H1|2 78.35 cM mouse Y529-p 448235 FTSTEPQyQPGENL_ enzymatic activity, inhibited cell differentiation, inhibited; cell differentiation, altered 36906292; 7691597 153 24 968 -Nox4 NOX4 Cell cycle regulation; EC 1.6.3.-; Membrane protein, integral; Membrane protein, multi-pass; Nucleolus; Oxidoreductase Q9JHI8 50490 7|7 D3 mouse Y566-p 57848101 LSNRNNSyGTKFEYN molecular association, regulation; enzymatic activity, inhibited CYBA(DISRUPTS) 27525436 1 1 0 -Plxna1 PLXNA1 Membrane protein, integral; Motility/polarity/chemotaxis; Receptor, misc. P70206 18844 6|6 D1 mouse Y1815-p 6154597 KSWVERYyADIAKMP Plexin_cytopl cytoskeletal reorganization 25485759 1 0 1 necessary for the collapse response of commissural growth cones to SlitC -SF3B2 SF3B2 RNA processing; RNA splicing; RNA-binding; Spliceosome Q13435 10992 11q13.1 human R508-m2 35483240 PRHWCFKrKYLQGKR DUF382 molecular association, regulation RNA splicing, induced SMN(INDUCES) 25737013 1 1 0 -Slc2a2 GLUT2 Membrane protein, integral; Membrane protein, multi-pass; Transporter; Transporter, SLC family P12336 25351 2q24 rat T510-p 451347 SAPPRKAtVQMEFLG activity, inhibited 8626492 1 0 0 Phosphorylation reduces the initial rate of 3-O-methyl glucose uptake. -RCHY1 RCHY1 EC 6.3.2.-; EC 6.3.2.19; Nuclear receptor co-regulator; UBIQUITIN LIGASE; Ubiquitin conjugating system; Ubiquitin ligase Q96PM5 25898 4q21.1 human S211-p 27971904 VAQTPMPsEYQNMTV zinc_ribbon_6 ubiquitination; activity, inhibited transcription, inhibited 23603988 1 0 0 self-ubiquitination, may contribute to p53-inhibition of transcriptional elongation of HIV-LTR -IGF2BP2 IGF2BP2 RNA-binding; Translation Q9Y6M1 10644 3q27.2 human K139-ub 63726986 EAKIAMEkLSGHQFE RRM_1 protein degradation; molecular association, regulation autophagy, induced RNA(INDUCES) 31791342 1 2 0 -Atm ATM DNA repair, damage; EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, Ser/Thr (non-receptor); Protein kinase, atypical; Tumor suppressor Q62388 11920 9 A5.3|9 29.12 cM mouse S367-p 467198 DTRSVEIsQSYVTQR chromatin organization, altered 19047460 3 9 2 -CIITA CIITA DNA-binding; EC 2.7.11.1; KINASE; Protein kinase, Ser/Thr (non-receptor); Transcription, coactivator/corepressor P33076 4261 16p13.13 human S373-p 1295502 VQARLERsSSKSLER molecular association, regulation; activity, inhibited transcription, inhibited SIN3B(INDUCES) 17991736 1 0 0 -CHRM2 mAChR M2 GPCR, family 1; Membrane protein, integral; Membrane protein, multi-pass; Receptor, GPCR P08172 1129 7q33 human Y177-p 487429 TVEDGECyIQFFSNA 7tm_1 molecular association, regulation; protein conformation 17525129; 18723515 2 0 0 -Notch1 Notch 1 Membrane protein, integral; Motility/polarity/chemotaxis; Oncoprotein; Receptor, misc.; Transcription factor Q01705 18128 2 A3|2 18.91 cM mouse T2122-p 386186602 HGTALGGtPTLSPTL protein degradation; ubiquitination cell differentiation, inhibited 29140246 1 0 0 -ARHGAP31 CdGAP GAP; GAP, Rac/Rho Q2M1Z3 57514 3q13.32-q13.33 human S1106-p 4694057 KGKNRPSsLNLDPAI molecular association, regulation; intracellular localization transcription, induced; cytoskeletal reorganization; cell motility, inhibited 14-3-3 beta(INDUCES); 14-3-3 sigma(INDUCES) 29545927 1 4 0 14-3-3? inhibits the ability of CdGAP to repress the E-cadherin promoter and to induce cell migration; 14-3-3? sequesters CdGAP into the cytoplasm and inhibits its ability to induce cell rounding -Atg13 ATG13 Autophagy; Vesicle Q91YI1 51897 2|2 E1 mouse S258-p 53377100 CTTSFSTsPPSQLSS autophagy, inhibited 26801615 1 1 0 -CCKBR CCKBR GPCR, family 1; Membrane protein, integral; Membrane protein, multi-pass; Receptor, GPCR P32239 887 11p15.4 human T440-p 17825902 LSRLSYTtISTLGPG molecular association, regulation ARRB1(INDUCES) 21156802 1 0 0 -ARHGAP35 GRF-1 GAP; GAP, Rac/Rho; Motility/polarity/chemotaxis; Transcription factor; Tumor suppressor Q9NRY4 2909 19q13.32 human S1150-p 457041 LERGRKVsIVSKPVL RhoGAP_pG1_pG2 molecular association, regulation; activity, inhibited RND1(DISRUPTS) 19103606 1 40 55 -BIK BIK Apoptosis; Membrane protein, integral; Mitochondrial Q13323 638 22q13.2 human S35-p 448349 EVLGMTDsEEDLDPM bcl-2I13 molecular association, regulation apoptosis, induced Bcl-2(INDUCES); Bcl-xL(INDUCES) 11084041; 14633680 3 0 0 -DYNLT1 DYNLT1 Microtubule-binding; Motility/polarity/chemotaxis; Motor P63171 282380 cow T94-p 456225 SSTDGSCtVRWENKT Tctex-1 molecular association, regulation endocytosis, induced Arp3(DISRUPTS) 28607034 7 0 0 Cdc42 activation, ciliary resorption -CEBPB C/EBP-beta DNA-binding; Motility/polarity/chemotaxis; Transcription factor P17676 1051 20q13.13 human Y78-p 9397201 RAIDFSPyLEPLGAP protein stabilization cell cycle regulation; apoptosis, altered; transcription, induced 19563810 1 0 0 -TEX12 TEX12 Q9BXU0 56158 11q23.1 human Y48-p 23152088 SEISGLFyKDEALEK TEX12 cell cycle regulation; carcinogenesis, induced; chromatin organization, altered; cell growth, induced 34880391 1 0 1 -Trpc6 TRPC6 Channel, cation; Membrane protein, integral; Membrane protein, multi-pass Q61143 22068 9 A1|9 2.46 cM mouse S28-p 22280200 AGTRRNEsQDYLLMD activity, inhibited 22001259 1 0 0 -PLEKHG6 PLEKHG6 GEF; GEF, Rac/Rho Q3KR16 55200 12p13.31 human T574-p 4145508 HLVVTEDtDEDAPLV activity, induced; intracellular localization 18694934 2 0 0 enhances PLEKHG6 activity towards RhoA -SKA3 SKA3 Cell cycle regulation Q8IX90 221150 13q12.11 human T203-p 1869388600 SLVKVLKtPKCALKM molecular association, regulation; intracellular localization cell cycle regulation; chromatin organization, altered; cytoskeletal reorganization HEC1(INDUCES) 32491969 1 1 0 -MAP2K6 MKK6 EC 2.7.12.2; KINASE; Kinase, protein; Protein kinase, STE; Protein kinase, dual-specificity (non-receptor) P52564 5608 17q24.3 human S207-p 448194 ISGYLVDsVAKTIDA Pkinase enzymatic activity, induced; phosphorylation transcription, induced; signaling pathway regulation 11460167; 21878628; 8622669 13 20 65 -ATF1 ATF-1 Transcription factor P18846 466 12q13.12 human T184-p 31858260 QTYQIRTtPSATSLP protein stabilization; molecular association, regulation; enzymatic activity, induced carcinogenesis, induced; cell motility, induced; cell growth, induced; transcription, induced PIN1(INDUCES) DNA(INDUCES) 28032861; 35397606 2 0 0 -PRKN PARK2 EC 6.3.2.-; EC 6.3.2.19; Ligase; Translation; Translation regulation; UBIQUITIN LIGASE; Ubiquitin conjugating system; Ubiquitin ligase O60260 5071 6q26 human S109-p 1872827404 LTRVDLSsSVLPGDS ubiquitination; intracellular localization; phosphorylation; enzymatic activity, induced autophagy, induced 33827825 1 1 0 induces phosphorylation at S65 and ubiquitination of substrates -ETS1 Ets-1 DNA-binding; Motility/polarity/chemotaxis; Oncoprotein; Transcription factor P14921 2113 11q24.3 human S257-p 449319 DSFESIEsYDSCDRL Ets1_N_flank molecular association, regulation; activity, inhibited transcription, inhibited DNA(DISRUPTS) 12475968 4 0 1 -HMGN1 HMGN1 DNA-binding; Nuclear receptor co-regulator P05114 3150 21q22.2 human K38-ac 458847 KVEAKPKkAAAKDKS HMG14_17 molecular association, regulation DNA(DISRUPTS) 10753971 1 0 0 -AICDA AID EC 3.5.4.38; Hydrolase Q9GZX7 57379 12p13.31 human T27-p 471423 WAKGRREtYLCYVVK APOBEC2 enzymatic activity, inhibited; enzymatic activity, induced 16387847; 21659520 5 2 0 class switch recombinaton -CLCN3 CLCN3 Channel, chloride; Membrane protein, integral; Membrane protein, multi-pass; Transporter; Transporter, ion channel; Vesicle P51790 1182 4q33 human S109-p 451427 ERHRRINsKKKESAW activity, induced; activity, inhibited neural plasticity 14754994; 23165767 2 0 0 -TJP1 ZO1 Adaptor/scaffold; Motility/polarity/chemotaxis Q07157 7082 15q13.1 human S168-p 470469 ASRERSLsPRSDRRS molecular association, regulation; intracellular localization ITGA5(INDUCES) 19567915 2 16 11 -RHO Rhodopsin GPCR, family 1; Membrane protein, integral; Membrane protein, multi-pass; Receptor, GPCR P08100 6010 3q22.1 human T336-p 3091410 GDDEASAtVSKTETS molecular association, regulation ARRB1(INDUCES) 28753425 2 3 0 -Tgm2 TGM2 EC 2.3.2.13; KINASE; Transferase P21981 21817 2 H1|2 78.72 cM mouse S216-p 467223 RDCSRRSsPIYVGRV activity, induced; enzymatic activity, induced cell cycle regulation; cell motility, induced; cell growth, induced; transcription, inhibited; signaling pathway regulation 22759359 3 4 2 phosphorylation of TGM2 at S216 causes NF-kB activation and downregulation of PTEN transcription, and consequently Akt activation. -BARD1 BARD1 EC 6.3.2.-; EC 6.3.2.19; Ligase; UBIQUITIN LIGASE; Ubiquitin conjugating system; Ubiquitin ligase Q99728 580 2q35 human T299-p 455768 KSRNEVVtPEKVCKN cell cycle regulation 15855157 2 11 24 resistance to genotoxic stress (mitomycin C) -Prm1 PRM1 Cancer Testis Antigen (CTA); DNA-binding P02319 19118 16 A1|16 5.87 cM mouse S43-p 36699681 RCCRRRRsYTIRCKK Protamine_P1 molecular association, regulation; intracellular localization chromatin organization, altered NPM2(INDUCES); HIRA(INDUCES) DNA(DISRUPTS) 32169215 1 1 0 induces protamine-to-histone exchange on DNA -RECQL5 RECQL5 DNA repair, damage; EC 3.6.4.12; Helicase O94762 9400 17q25.1 human S727-p 4767154 SAHYGGPsPEKKAKS RecQ5 cell cycle regulation 28575661 1 23 0 -AURKB AurB EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, Other; Protein kinase, Ser/Thr (non-receptor) Q96GD4 9212 17p13.1 human T232-p 450325 APSLRRKtMCGTLDY Pkinase intracellular localization; phosphorylation; enzymatic activity, induced cell cycle regulation; carcinogenesis, induced; cytoskeletal reorganization INCENP(INDUCES) 14722118; 19203582; 20171103; 24344188; 26829474; 27557660; 28004745; 31819079; 35301407 34 17 90 -Blnk BLNK Adaptor/scaffold Q9QUN3 17060 19 C3|19 34.26 cM mouse K37-ub 23303203 GGIMDKIkKLKVKGP molecular association, regulation; ubiquitination 14-3-3 beta(INDUCES) 22334673 1 0 0 Thr-152 phosphorylation induces BLNK ubiquitination at K37, K38, K42. -GATAD2A GATAD2A Transcription factor Q86YP4 54815 19p13.11 human K487-sm 3755611 GTAPAQAkAEPTAAP transcription, inhibited 16738318 1 1 0 -AR AR DNA-binding; Nuclear receptor; Transcription factor P10275 367 Xq12 human S792-p 448415 CVRMRHLsQEFGWLQ Hormone_recep intracellular localization chromatin organization, altered; apoptosis, inhibited; transcription, altered 17470458; 23945560 5 0 0 low phosphorylation associated with increased androgen receptor gene amplification; Mutation reduces transport to the nucleus. S213A and S791A mutations reduce binding to androgen. -EIF2S1 eIF2-alpha RNA-binding; Translation; Translation initiation P05198 1965 14q23.3 human S49-p 450210 IEGMILLsELSRRRI S1 molecular association, regulation translation, altered eIF2-beta(INDUCES); PERK(INDUCES) 16288713 4 1 0 -RBL2 Rb-like 2 Transcription, coactivator/corepressor; Tumor suppressor Q08999 5934 16q12.2 human S1080-p 449741 IFYYFSNsPSKRLRE molecular association, regulation; intracellular localization cell cycle regulation KPNA1(DISRUPTS); E2F4(DISRUPTS) 11157749; 12006580; 20857408 5 10 0 -PPARA PPAR-alpha DNA-binding; Nuclear receptor; UBIQUITIN LIGASE Q07869 5465 22q13.31 human S21-p 1789803 LEAGDLEsPLSEEFL activity, induced; protein stabilization signaling pathway regulation; transcription, inhibited 18079279; 21224484; 21525007 4 0 0 increases SR-BI stability, increases cholesterol efflux. -Nkx3-2 NKX3-2 Cell development/differentiation; DNA-binding; Transcription factor P97503 12020 5 B3|5 22.58 cM mouse K262-ub 1593379701 QNRRYKTkRRQMAAD Homeodomain molecular association, regulation apoptosis, inhibited IKKG(INDUCES) 21606193 1 1 0 ubiquitination-dependent interaction with IKKG (aka NEMO) promotes formation of the complex NKX3.2-IKKG(NEMO)-IKKB -Ripk1 RIPK1 EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, Ser/Thr (non-receptor); Protein kinase, TKL Q60855 19766 13 A3.3|13 14.01 cM mouse S336-p 209632700 LPPSRSNsEQPGSLH molecular association, regulation; enzymatic activity, induced apoptosis, inhibited RIPK3(INDUCES) 28842570; 28920952; 28920954 4 2 0 -CRK CRK Adaptor/scaffold; Motility/polarity/chemotaxis; Oncoprotein Q04929 417553 chicken Y222-p 447951 GGPEPGPyAQPSINT molecular association, regulation; protein conformation cell differentiation, altered; cell adhesion, altered PXN(DISRUPTS); Abl(DISRUPTS); Abl iso2(DISRUPTS) 10825157; 17289588 25 14 1168 -CKMT2 CKMT2 Amino Acid Metabolism - arginine and proline; EC 2.7.3.2; Kinase, other; Mitochondrial P17540 1160 5q14.1 human Y159-p 1914421 QGQFDEHyVLSSRVR enzymatic activity, induced transcription, induced; signaling pathway regulation 34095014 1 2 56 induces PGC-1a/estrogen-related receptor-a pathway -RBL2 Rb-like 2 Transcription, coactivator/corepressor; Tumor suppressor Q08999 5934 16q12.2 human S948-p 449731 SGSSDSRsHQNSPTE RB_B molecular association, regulation cell cycle regulation E2F4(DISRUPTS) 11157749 2 12 0 -MUC1 MUC1 Actin-binding; Cell adhesion; Membrane protein, integral; Motility/polarity/chemotaxis; Nuclear receptor co-regulator; Tumor suppressor P15941 4582 1q22 human T1224-p 455682 RYVPPSStDRSPYEK molecular association, regulation cell growth, altered 11877440 2 1 3 -Ulk1 ULK1 Autophagy; EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, Other; Protein kinase, Ser/Thr (non-receptor) O70405 22241 5|5 F mouse S317-p 35495300 SHLASPPsLGEMPQL autophagy, induced 21258367 20 1 0 -BRCA1 BRCA1 EC 6.3.2.-; Nuclear receptor co-regulator; Transcription, coactivator/corepressor; Tumor suppressor; UBIQUITIN LIGASE; Ubiquitin conjugating system; Ubiquitin ligase P38398 672 17q21.31 human K119-sm 11539302 NNSPEHLkDEVSIIQ molecular association, regulation; enzymatic activity, induced DNA repair, induced 20016594 1 0 0 -Ppm1j PPM1J EC 3.1.3.16; PHOSPHATASE; Protein phosphatase, Ser/Thr (non-receptor) Q149T7 71887 3|3 F2.2 mouse S92-p 2846507 HAGRAVQsPPDTGRR enzymatic activity, inhibited; protein conformation 18553930 1 0 0 -CTLA4 CTLA-4 Immunoglobulin superfamily; Membrane protein, integral P16410 1493 2q33.2 human Y201-p 450897 SPLTTGVyVKMPPTE molecular association, regulation; intracellular localization SHP-1(INDUCES) 10604992; 11970985 5 0 1 -CDC34 CDC34 EC 6.3.2.19; Ligase; UBIQUITIN LIGASE; Ubiquitin conjugating system; Ubiquitin ligase P49427 997 19p13.3 human S203-p 448687 APAPDEGsDLFYDDY intracellular localization 11546811 2 0 0 -ID3 ID3 DNA-binding; Transcription, coactivator/corepressor Q02535 3399 1p36.12 human Y11-p 15411043 LSPVRGCyEAVCCLS protein stabilization 25090023 1 1 10 regulates vascular EC survival and growth of microvascular lesions -Npy1r NPY1R GPCR, family 1; Membrane protein, integral; Membrane protein, multi-pass; Receptor, GPCR P21555 29358 16p14 rat S352-p 455138 DYETIAMsTMHTDVS receptor desensitization, altered; receptor internalization, altered 15576634 1 0 0 may be an artifact of the truncation mutants -DEK DEK DNA replication; DNA-binding; Histone-binding; Oncoprotein; RNA splicing P35659 7913 6p22.3 human S19-p 465615 GTPTQPAsEKEPEMP molecular association, regulation RNA splicing, altered U2AF1(INDUCES) 16809543 2 8 0 -Kcna2 Kv1.2 Channel, potassium; Membrane protein, integral; Membrane protein, multi-pass P63142 25468 2q34 rat S449-p 1818102 PDLKKSRsASTISKS intracellular localization; phosphorylation 18056633 2 3 1 reduces phosphorylation on S440/S441 -EIF6 EIF6 Nucleolus; Translation; Translation initiation P56537 3692 20q11.22 human T231-p 31863506 LNEAQPStIATSMRD intracellular localization translation, altered 32703900 1 2 0 -PRKDC DNAPK DNA repair, damage; EC 2.7.11.1; KINASE; Kinase, protein; Nucleolus; Protein kinase, Ser/Thr (non-receptor); Protein kinase, atypical P78527 5591 8q11.21 human S2675-p 3193637 VDHTSPSsDSLLFAH DNAPKcs_CC5 DNA repair, inhibited 24687855 1 2 0 cell survival inhibited -HOXB13 HOXB13 DNA-binding; Transcription factor Q92826 10481 17q21.32 human T41-p 1883583908 TSHPAAPtLMPAVNY protein degradation; molecular association, regulation; ubiquitination; intracellular localization carcinogenesis, induced; cell growth, induced; transcription, altered SKP2(INDUCES) 37409967 1 0 0 induces nuclear translocation of NFKB -MACC1 MACC1 Q6ZN28 346389 7p21.1 human Y673-p 1874020218 VLADVLGySHLSLED phosphorylation carcinogenesis, induced; cell motility, induced; cell growth, induced; transcription, induced 34247190 1 1 0 -PTK2 FAK EC 2.7.10.2; KINASE; Kinase, protein; Protein kinase, TK; Protein kinase, tyrosine (non-receptor) Q05397 5747 8q24.3 human Y861-p 447965 PIGNQHIyQPVGKPD activity, induced; molecular association, regulation; intracellular localization; activity, inhibited; enzymatic activity, induced; phosphorylation carcinogenesis, induced; apoptosis, altered; cell growth, induced; cell motility, induced; cytoskeletal reorganization; cell adhesion, altered; cell growth, altered P130Cas(INDUCES); ITGB5(INDUCES) 11839732; 11927607; 12084011; 15123632; 15735019; 16461767; 18794113; 21852560; 21994943; 25868388; 34169835; 34335982; 35257717; 35999654 75 21 307 -DCBLD2 DCBLD2 Cell adhesion; Membrane protein, integral Q96PD2 131566 3q12.1|3 human Y732-p 455063 CSSAQAQyDTPKAGK molecular association, regulation CRKL(INDUCES) 23770091 1 14 193 -Tbc1d4 AS160 GAP; GAP, Rab Q8BYJ6 210789 14|14 E2.3 mouse T649-p 455921 QFRRRAHtFSHPPSS molecular association, regulation; intracellular localization; phosphorylation endocytosis, induced; signaling pathway regulation 14-3-3 beta(INDUCES); IRAP(DISRUPTS) 19897488; 19923418; 20332342; 21195350; 33872597 45 21 134 Rictor/mTORC2 signaling in energy metabolism in fat cells; regulates GLUT4 trafficking, induces glucose uptake -PTPN12 PTP-PEST EC 3.1.3.48; Motility/polarity/chemotaxis; PHOSPHATASE; Protein phosphatase, tyrosine (non-receptor) Q05209 5782 7q11.23 human S39-p 451311 FMRLRRLsTKYRTEK molecular association, regulation; enzymatic activity, inhibited; activity, inhibited HER2(DISRUPTS) 28842430; 7520867 5 0 15 -Oprl1 KOR-3 GPCR, family 1; Membrane protein, integral; Membrane protein, multi-pass; Receptor, GPCR P35370 29256 3q43 rat S334-p 456132 FRKFCCAsSLHREMQ activity, induced; receptor desensitization, altered 16019191 1 0 0 -AURKB AurB EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, Other; Protein kinase, Ser/Thr (non-receptor) Q9N0X0 396955 pig T232-p 450325 APSLRRKtMCGTLDY Pkinase enzymatic activity, induced 16452462 34 17 90 -TP63 p63 DNA-binding; Transcription factor Q9H3D4 8626 3q28 human T46-p 912008301 TMSQSTQtNEFLSPE transcription, induced 29559659 1 0 0 Induction of LCE1C and ANXA8L1 transcription -ENG ENG Membrane protein, integral; Motility/polarity/chemotaxis; Receptor, misc. P17813 2022 9q34.11 human S635-p 465619 AVAAPASsESSSTNH phosphorylation 16785228 1 1 0 required for threonine phosphorylation of ENG -Epas1 HIF2A DNA-binding; Transcription factor P97481 13819 17|17 E4 mouse S834-p 2085802 ASRLLGPsFEPYLLP transcription, inhibited 11983697 1 0 0 -CARD9 CARD9 Adaptor/scaffold Q9H257 64170 9q34.3 human T531-p 1206001 NTTGSDNtDTEGS__ activity, inhibited 17936701 1 1 0 impairs ability of CARD9 to activate NF-kB -Bnip3 BNIP3 Membrane protein, integral; Mitochondrial O55003 12176 7|7 F4 mouse T181-p 41388500 IYIGRRLtTSTSTF_ BNIP3 molecular association, regulation; intracellular localization 14-3-3 beta(INDUCES) 34824192 2 2 0 -GPBAR1 GPBAR1 GPCR, family 1; Membrane protein, integral; Membrane protein, multi-pass; Receptor, GPCR Q8TDU6 151306 2q35 human S321-p 1877729202 SIAYHPSsQSSVDLD molecular association, regulation cell growth, induced; apoptosis, inhibited ARRB1(INDUCES) 35858343 0 1 0 -Ywhag 14-3-3 gamma Adaptor/scaffold P61982 22628 5|5 G2 mouse K50-ac 474722 NLLSVAYkNVVGARR 14-3-3 molecular association, regulation STAR(INDUCES) 25086053 1 5 15 -ERCC6 ERCC6 DNA repair, damage; EC 3.6.1.-; EC 3.6.4.-; Helicase; Transcription regulation Q03468 2074 10q11.23 human T1031-p 1875831800 GTGSDVQtPKCHLKR molecular association, regulation; intracellular localization DNA repair, altered MRE11A(INDUCES) 34871413 1 0 0 -Cited1 CITED1 Nuclear receptor co-regulator P97769 12705 X D|X 45.25 cM mouse S69-p 27937111 TSSSGSTsPIGSPTA CITED intracellular localization cell differentiation, induced 23529225 1 0 0 S63/64/65/67/69/73/79/80/84A mutation in CITED1 inhibits its translocation into the nucleus and osteoblasts differentiation -MAPK1 ERK2 EC 2.7.11.24; KINASE; Kinase, protein; Protein kinase, CMGC; Protein kinase, Ser/Thr (non-receptor) P28482 5594 22q11.22 human T185-p 447593 HDHTGFLtEYVATRW Pkinase activity, induced; protein degradation; molecular association, regulation; intracellular localization; protein conformation; phosphorylation; enzymatic activity, induced cell cycle regulation; carcinogenesis, induced; apoptosis, altered; cell motility, induced; transcription, induced; signaling pathway regulation; cell growth, induced; cell differentiation, induced; cell motility, altered; cytoskeletal reorganization; transcription, inhibited; cell growth, altered G-beta 1(INDUCES); TACE(INDUCES); leupaxin(NOT_REPORTED); GSK3B(INDUCES); p90RSK(INDUCES); KSR(INDUCES); NFkB-p100(DISRUPTS) 10597231; 10925301; 11352917; 12609989; 12808105; 15004239; 16149052; 16397900; 17562849; 17667937; 17685427; 18042541; 18045996; 18519681; 18658095; 18775330; 19060905; 19088846; 19106095; 19144315; 20122898; 20231899; 20868520; 21478863; 21530327; 21561860; 21685939; 21726627; 21730054; 21842857; 21893193; 21917714; 21980390; 22385658; 23644655; 25538243; 25730857; 26079947; 26686085; 27323830; 28574827; 30987999; 31722981; 31736979; 31964804; 34017102; 34226680; 36289618 1139 120 2416 autoamplifcation of NFAT-c1, which promotes osteoclast differentiation, suppressed by MLN4924 -HIPK2 HIPK2 EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, CMGC; Protein kinase, Ser/Thr (non-receptor) Q9H2X6 28996 7q34 human T566-p 27732205 DTVNQSKtPFITHVA enzymatic activity, induced cell growth, inhibited 28060750 1 2 0 IPK2-T566P mutant showed a very mild reduction of kinase activity -Aida AIDA Cell development/differentiation Q8C4Q6 108909 1|1 H5 mouse S161-p 15495718 TLLPRLPsEPGMTLL Aida_C2 molecular association, regulation; intracellular localization UCP1(INDUCES) 33664495 1 11 0 activates thermogenesis -NFATC3 NFAT4 DNA-binding; Transcription factor Q12968 4775 16q22.1 human S165-p 448858 RESSLSPsPASSISS intracellular localization transcription, inhibited 9374467 2 2 0 -BECN1 beclin 1 Adaptor/scaffold; Autophagy; Membrane protein, peripheral Q14457 8678 17q21.31 human S234-p 27156802 AQYQREYsEFKRQQL APG6_N cell cycle regulation; carcinogenesis, induced; autophagy, inhibited 34077419 3 0 0 -HGS Hrs Adaptor/scaffold; Motility/polarity/chemotaxis O14964 9146 17q25.3 human Y329-p 450191 IDPELARyLNRNYWE intracellular localization; receptor recycling, altered; phosphorylation 12953068; 17101784 2 10 170 Hrs phosphorylation mutant Y329,334F is unable to degrade ubiquinated EGFR. ; Cbl expression alters Hrs phosphorylation and fractionation in membrane and cyosokic fractions. -RBL2 Rb-like 2 Transcription, coactivator/corepressor; Tumor suppressor Q08999 5934 16q12.2 human S966-p 449734 DRTSRDSsPVMRSSS RB_B molecular association, regulation cell cycle regulation E2F4(DISRUPTS) 11157749 2 3 1 -KIF2B KIF2B Microtubule-binding; Motor Q8N4N8 84643 17q22 human S201-p 25247534 YRRHLDSsKISVLEP intracellular localization cell cycle regulation 22535524 1 1 0 -Actr2 ARP2 Actin-binding; Cytoskeletal; Motility/polarity/chemotaxis P61161 66713 11 A3.1|11 12.88 cM mouse T238-p 36440501 QKLALETtVLVESYT Actin intracellular localization 28947541 4 0 0 colocalization with F-actin (decreased in aging macrophages) -H3C1 H3 DNA-binding P68431 8350 6p22.2 human K56-ac 3804954 REIRRYQkSTELLIR Histone molecular association, regulation; intracellular localization cell cycle regulation; cell differentiation, inhibited; carcinogenesis, induced; apoptosis, induced; transcription, induced; transcription, altered; cell differentiation, altered; DNA repair, induced; chromatin organization, altered; DNA repair, altered; cell growth, altered SMAD4(INDUCES); SMAD2(INDUCES); SMAD3(INDUCES) DNA(INDUCES); DNA(DISRUPTS) 19250903; 19270680; 19407812; 19411844; 19625767; 19818718; 20100606; 20347425; 20462404; 20520775; 20587414; 23287868; 26255936; 31071955; 31815277 33 14 2 Hdac1/2 knock-out thymocytes: importnant for T-cell development and genomic stability; increased upon successful completion of DNA repair ; HDACi panobinostat induced apoptosis in K562 and K562-IR cells -RAD52 RAD52 DNA repair, damage P43351 5893 12p13.33 human Y104-p 449061 DLNNGKFyVGVCAFV Rad52_Rad22 activity, induced; molecular association, regulation; intracellular localization DNA repair, induced DNA(INDUCES) 12379650; 21804533; 23836560 4 0 0 enhances ssDNA annealing activity by attenuating dsDNA binding.; single-strand annealing but not homologous recombination repair -PBK PBK Cancer Testis Antigen (CTA); EC 2.7.12.2; KINASE; Kinase, protein; Protein kinase, Other; Protein kinase, Ser/Thr (non-receptor); Protein kinase, dual-specificity (non-receptor) Q96KB5 55872 8p21.1 human S32-p 471715 PTINIPAsPFMQKLG carcinogenesis, induced; cell growth, induced; apoptosis, inhibited 35546143 1 16 33 -Hmga1 HMGA1 DNA-binding Q8K585 117062 20p12 rat S44-p 479856 PGTALVGsQKEPSEV molecular association, regulation DNA(DISRUPTS) 10617144 2 43 17 -CDC25B CDC25B iso2 EC 3.1.3.48; Motility/polarity/chemotaxis; Nuclear receptor co-regulator; PHOSPHATASE; Protein phosphatase, dual-specificity P30305-2 994 20p13 human S101-p 9819902 DAGLCMDsPSPMDPH M-inducer_phosp protein degradation; ubiquitination cell cycle regulation 19638579; 21807946 2 0 0 -TFEB TFEB DNA-binding; Transcription factor P19484 7942 6p21.1 human S114-p 3181613 HISPAQGsPKPPPAA MITF_TFEB_C_3_N activity, induced; intracellular localization transcription, inhibited; cell growth, altered 29945972 2 35 0 -IGF1R IGF1R EC 2.7.10.1; KINASE; Kinase, protein; Membrane protein, integral; Protein kinase, TK; Protein kinase, tyrosine (receptor) P08069 3480 15q26.3 human Y1165-p 448387 RDIYETDyYRKGGKG PK_Tyr_Ser-Thr molecular association, regulation; protein conformation; enzymatic activity, induced carcinogenesis, induced; autophagy, induced; cell motility, induced; apoptosis, inhibited Cbl-c(INDUCES) 11591350; 16793764; 34921013; 36543142 20 38 707 -LONP1 PRSS15 DNA-binding; EC 3.4.21.-; Mitochondrial; Protease; RNA-binding P36776 9361 19p13.3 human S173-p 1869121004 VFLKRDDsNESDVVE LON_substr_bdg enzymatic activity, induced carcinogenesis, inhibited 31406245 1 1 0 regulation of mitochondrial bioenergetics -CPNE1 CPNE1 Lipid-binding Q99829 8904 20q11.22 human K157-ub 12313481 DKKDFLGkSDPFLEF C2 protein degradation carcinogenesis, induced; cell growth, induced 34743202 1 5 26 -Nos1 nNOS Amino Acid Metabolism - arginine and proline; EC 1.14.13.39; Oxidoreductase P29476 24598 12q16 rat K989-ac 2459100 QGLSNVHkKRVSAAR FAD_binding_1 activity, induced 18415985 1 1 0 -DLG1 DLG1 Adaptor/scaffold; Motility/polarity/chemotaxis Q12959 1739 3q29 human S158-p 2024309 FVSHSHIsPIKPTEA MAGUK_N_PEST protein degradation; protein stabilization; molecular association, regulation; ubiquitination; intracellular localization cytoskeletal reorganization GKAP1(DISRUPTS) 15729360; 19066288; 19307009 4 16 0 -GAD1 GAD67 Amino Acid Metabolism - alanine, aspartate and glutamate; Carbohydrate Metabolism - butanoate; EC 4.1.1.15; Lyase; Mitochondrial; Other Amino Acids Metabolism - beta-alanine; Other Amino Acids Metabolism - taurine and hypotaurine Q99259 2571 2q31.1 human T91-p 451699 RDARFRRtETDFSNL activity, inhibited 15147202 1 1 0 -Khdrbs1 KHDRBS1 RNA-binding Q60749 20218 4|4 D2.2 mouse Y440-p 456716 GAYREHPyGRY____ intracellular localization 16179349 1 0 26 -Rcan1 RCAN1 Inhibitor Q9JHG6 54720 16 C4|16 53.6 cM mouse S146-p 25687504 AQTLHIGsSHLAPPN Calcipressin molecular association, regulation PPP3CA(DISRUPTS) 22864830 3 2 0 -ETS1 Ets-1 DNA-binding; Motility/polarity/chemotaxis; Oncoprotein; Transcription factor P14921 2113 11q24.3 human S269-p 1873117008 DRLTQSWsSQSSFNS Ets1_N_flank activity, induced; protein stabilization; molecular association, regulation carcinogenesis, induced; cell motility, induced; transcription, induced; signaling pathway regulation p300(INDUCES) DNA(INDUCES) 34023818 1 1 0 transcriptional activation of matrix metalloproteinase (MMP)-9; inhibits ubiquitination, regulates GSK3?/ETS1/MMP-9 signaling -NDC80 HEC1 Cell cycle regulation O14777 10403 18p11.32 human S50-p 12667684 LSINKPTsERKVSLF cytoskeletal reorganization 35878017 1 5 0 -TNS3 tensin 3 Adaptor/scaffold; Motility/polarity/chemotaxis Q68CZ2 64759 7p12.3 human Y1206-p 9824601 SHSFRGAyGLAMKVA SH2 molecular association, regulation cell motility, altered; cell growth, altered P130Cas(INDUCES); KHDRBS1(INDUCES); FAK(INDUCES) 19732724 1 0 0 contributes to tumorigenesis and metastasis -TP63 p63 DNA-binding; Transcription factor Q9H3D4 8626 3q28 human S479-p 4668107 MNKLPSVsQLINPQQ activity, induced; protein degradation; molecular association, regulation cell growth, inhibited; apoptosis, induced; transcription, altered NFYA(INDUCES) DNA(INDUCES) 18769144; 20023394 2 1 0 -Rb1 Rb Nuclear receptor co-regulator; Oncoprotein; Transcription, coactivator/corepressor; Tumor suppressor P33568 24708 15q11 rat T818-p 447984 LPTPTKMtPRSRILV Rb_C cell cycle regulation 20484410 20 37 56 -Stmn1 STMN1 Cytoskeletal P54227 16765 4 D3|4 66.76 cM mouse S38-p 448556 SVPDFPLsPPKKKDL Stathmin protein stabilization; phosphorylation carcinogenesis, induced; cell motility, induced; cell growth, induced; apoptosis, induced; signaling pathway regulation 20630875; 21646391; 36484700 49 114 166 -DYRK1B DYRK1B EC 2.7.12.1; KINASE; Kinase, protein; Protein kinase, CMGC; Protein kinase, dual-specificity (non-receptor) Q9Y463 9149 19q13.2 human S421-p 50269512 YEPAARIsPLGALQH Pkinase enzymatic activity, induced 26346493 1 3 0 -FOXO1 FOXO1A DNA-binding; Nuclear receptor co-regulator; Oncoprotein; Transcription factor Q12778 2308 13q14.11 human S319-p 449113 TFRPRTSsNASTISG activity, induced; molecular association, regulation; intracellular localization cell differentiation, inhibited; apoptosis, altered; cell growth, induced; signaling pathway regulation; transcription, altered; transcription, inhibited IQGAP1(INDUCES) 12228231; 14664696; 15934941; 16670091; 18794113; 20061393; 21697492; 23995784; 28279977; 34948236; 35966593 29 5 27 -CTNNAL1 CTNNAL1 Adaptor/scaffold Q9UBT7 8727 9q31.3 human Y536-p 479128 RRGEKYGyLSLPKPM intracellular localization 17952117 1 1 21 mutantsand wild-type were localized throughout the cytoplasm, and partially associated with the plasma membrane -Sphk1 SPHK1 ACETYLTRANSFERASE; Acetyltransferase; EC 2.3.1.-; EC 2.7.1.91; Kinase, lipid; Lipid Metabolism - sphingolipid Q8CI15 20698 11|11 E2 mouse S373-p 51621300 DAPSGRDsRRGPPPE enzymatic activity, inhibited 26642194 1 0 0 -RPS3 RPS3 Apoptosis; EC 4.2.99.18; RNA-binding; Ribosomal; Translation P23396 6188 11q13.4 human R67-m2 9184303 GEKGRRIrELTAVVQ KH_2 intracellular localization 19460357 1 0 0 regulates ribosome assembly -Stmn2 STMN2 Cytoskeletal P21818 84510 2q23 rat S73-p 450173 EAPRTLAsPKKKDLS Stathmin cytoskeletal reorganization 9525956 9 1 0 -YKT6 YKT6 EC 2.3.1.-; Endoplasmic reticulum; Membrane protein, integral; Transferase; Vesicle O15498 10652 7p13 human S174-p 27456090 LDDLVSKsEVLGTQS Synaptobrevin molecular association, regulation; intracellular localization; protein conformation cell growth, inhibited; autophagy, inhibited GOSR2(DISRUPTS); SCFD1(DISRUPTS); STX17(DISRUPTS); SNAP29(DISRUPTS) 33723042 2 6 0 -DGCR8 DGCR8 Nucleolus; RNA processing; RNA-binding Q8WYQ5 54487 22q11.21 human S153-p 34490414 AECGLLLsPVSGDVH DNA repair, inhibited 28380355 1 1 0 -DDX5 DDX5 EC 3.6.4.13; Helicase; Nuclear receptor co-regulator; Nucleolus; RNA splicing; RNA-binding; Spliceosome P17844 1655 17q23.3 human Y593-p 470084 NGMNQQAyAYPATAA molecular association, regulation; intracellular localization cell growth, induced; apoptosis, inhibited; transcription, induced; cytoskeletal reorganization CTNNB1(INDUCES) 17018282; 17384675; 17412694 4 2 1 transcription of cyclin D1 and c-Myc genes -IGFBP3 IGFBP3 Cell development/differentiation; Secreted; Secreted, signal peptide P17936 3486 7p12.3 human S156-p 37046603 VESPSVSsTHRVSDP apoptosis, inhibited 25525174 1 0 0 involved in pioglitazone-induced regulation of IGFBP-3 -AKT1S1 PRAS40 Apoptosis Q96B36 84335 19q13.33 human S202-p 454571 EKRTEARsSDEENGP PRAS molecular association, regulation cell growth, induced; autophagy, inhibited 14-3-3 beta(INDUCES); Raptor(DISRUPTS) 26876154 2 45 109 activates mTORC1 -CDK2 CDK2 Cell cycle regulation; EC 2.7.11.22; KINASE; Kinase, protein; Protein kinase, CMGC; Protein kinase, Ser/Thr (non-receptor) P24941 1017 12q13.2 human T39-p 2712201 LKKIRLDtETEGVPS Pkinase intracellular localization cell cycle regulation; apoptosis, induced 18354084 1 1 0 contributes to the cell death induced by methotrexate and docetaxel -Slc1a6 SLC1A6 Membrane protein, integral; Membrane protein, multi-pass; Transporter; Transporter, SLC family O35921 84012 7q11 rat T40-p 480172 RTRLRLQtMTREHVR intracellular localization 17442044 1 0 0 -Myog myogenin DNA-binding; Transcription factor P12979 17928 1 E4|1 58.18 cM mouse T57-p 1880114102 LEEKGLGtPEHCPGQ protein degradation; molecular association, regulation; ubiquitination transcription, inhibited FBXO32(INDUCES) 36259412 1 0 0 -CDC42 CDC42 iso1 G protein; G protein, monomeric; G protein, monomeric, Rho; Motility/polarity/chemotaxis P60953-1 998 1p36.12 human Y64-p 450272 DTAGQEDyDRLRPLS Ras activity, induced; molecular association, regulation cell growth, altered RhoGDI alpha(INDUCES) 14506284 1 2 29 Cdc42 Y64A mutant is impaired in transforming NIH 3T3 cells. -LCP2 SLP76 Adaptor/scaffold Q13094 3937 5q35.1 human K284-sm 1878271703 EHLPKIQkPPLPPTT transcription, induced 31666306 1 1 0 enhances NFAT-driven IL-2 transcription -ABL1 Abl EC 2.7.10.2; KINASE; Kinase, protein; Oncoprotein; Protein kinase, TK; Protein kinase, tyrosine (non-receptor) P00519 25 9q34.12 human Y253-p 450301 HKLGGGQyGEVYEGV PK_Tyr_Ser-Thr intracellular localization; protein conformation; enzymatic activity, induced 18775312; 21347248 4 8 277 -LRRK1 LRRK1 EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, Ser/Thr (non-receptor); Protein kinase, TKL Q38SD2 79705 15q26.3 human Y971-p 23303206 TQQTEEQyFQFLAKF COR intracellular localization; enzymatic activity, inhibited endocytosis, altered 22337768; 36744428 2 0 0 regulates endosomal trafficking of EGFR -ESCO2 ESCO2 ACETYLTRANSFERASE; Acetyltransferase; DNA replication; EC 2.3.1.- Q56NI9 157570 8p21.1 human S196-p 1881957102 SNAPRVLsQKIKPQV molecular association, regulation; intracellular localization carcinogenesis, induced; DNA repair, induced MDC1(INDUCES) 37377435 1 0 0 -Cry2 CRY2 DNA-binding; Lyase Q9R194 12953 2|2 E1 mouse K241-ub 22242792 EALARLDkHLERKAW protein degradation; intracellular localization 23452856 1 2 0 -PTPRCAP PTPRCAP Cell surface; Membrane protein, integral Q14761 5790 11q13.2 human S163-p 4733815 EGDLVLGsPGPASAG PTPRCAP signaling pathway regulation 31537385 3 1 1 PKC, MAPK pathway -Dgka DGKA EC 2.7.1.107; Kinase, lipid; Lipid Metabolism - glycerolipid; Lipid Metabolism - glycerophospholipid; Motility/polarity/chemotaxis O88673 13139 10 D3|10 77.14 cM mouse Y336-p 486452 ILPPCSIyPSVLVSG intracellular localization 17911109 5 0 0 translocates to the plasma membrane after stimulation of endogenous T cell receptor (TCR) with anti-CD3/C28 -CDH5 CDH5 Cell adhesion; Membrane protein, integral; Motility/polarity/chemotaxis P33151 1003 16q21 human Y685-p 455658 LDARPSLyAQVQKPP receptor internalization, induced; molecular association, regulation CSK(INDUCES) 16909109; 33712448 18 4 145 -Nfatc2 NFAT1 DNA-binding; Transcription factor Q60591 18019 2 H3|2 88.91 cM mouse T116-p 455763 PSPRIEItPSHELMQ activity, induced; molecular association, regulation transcription, induced PPP3CA(INDUCES) 15743762 1 4 0 -ENO1 ENO1 Carbohydrate Metabolism - glycolysis and gluconeogenesis; EC 4.2.1.11; Lyase; Transcription, coactivator/corepressor P06733 2023 1p36.23 human S115-p 55578724 ANAILGVsLAVCKAG Enolase_N enzymatic activity, inhibited 27153534 1 1 0 -TP53BP1 53BP1 DNA repair, damage; Transcription, coactivator/corepressor Q12888 7158 15q15.3 human S380-p 452380 TPFIVPSsPTEQEGR molecular association, regulation DNA repair, induced SCAI(INDUCES) 28700933 3 59 6 other sites are involved in binding to SCAI -Kcnma1 KCNMA1 iso5 Channel, potassium; Endoplasmic reticulum; Membrane protein, integral; Membrane protein, multi-pass Q08460-5 16531 14|14 A3 mouse S692-p 27842903 SNVKKYDsTGMFHWC activity, induced 23407708 1 0 0 regulates NO/cGMP signaling -ARHGAP35 GRF-1 GAP; GAP, Rac/Rho; Motility/polarity/chemotaxis; Transcription factor; Tumor suppressor Q9NRY4 2909 19q13.32 human T1226-p 7159800 LRSLRRNtKKPKPKP RhoGAP_pG1_pG2 molecular association, regulation; activity, inhibited cytoskeletal reorganization 19103606; 19673492 2 0 1 prevents the association of the protein with acidic phospholipids and modulate the GTPase substrate preference -SRF SRF Motility/polarity/chemotaxis; Transcription factor P11831 6722 6p21.1 human S253-p 13203801 LTYQVSEsDSSGETK transcription, inhibited 8375385 1 1 0 -ADD1 ADD1 Cytoskeletal; Motility/polarity/chemotaxis P35611 118 4p16.3 human T445-p 449480 QKQQREKtRWLNSGR activity, induced; intracellular localization cytoskeletal reorganization 10209029; 15910744 6 0 0 Phosphorylation at T445 induced by STA2 translocated p-T445 into triton insoluble low speed fraction while p-S726 did not show any translocation of fractions. This translocation was inhibited by Y27632. ; phosphorylation of this site by Rho-kinase regulates membrane ruffling and cell motility. -CCNB1 CCNB1 Activator; Cell cycle regulation P14635 891 5q13.2 human S133-p 448445 SPSPMETsGCAPAEE intracellular localization DNA(INDUCES) 11242082; 12447691; 20117088; 22726437 7 1 0 S133-p is required for accelerated nuclear import. ; The phosphorylation of S133 and S147 is necessary for the nuclear translocation of cyclin B1 during G2/M phase.; enhances nuclear import -RIPK1 RIPK1 EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, Ser/Thr (non-receptor); Protein kinase, TKL Q13546 8737 6p25.2 human K115-ub 2188101 MSTPLSVkGRIILEI PK_Tyr_Ser-Thr phosphorylation transcription, induced; signaling pathway regulation 27518435 3 3 0 induces necroptotic cell death signaling -SLAMF6 SLAMF6 Membrane protein, integral; Receptor, misc. Q96DU3 114836 1q23.2-q23.3 human Y309-p 457710 ENDTITIySTINHSK molecular association, regulation; phosphorylation cell adhesion, induced; signaling pathway regulation Lck(INDUCES); SH2D1A(INDUCES) 24688028; 31199820 2 9 269 necessary for ERK phosphorylation -MAP2K2 MEK2 EC 2.7.12.2; KINASE; Kinase, protein; Protein kinase, STE; Protein kinase, dual-specificity (non-receptor) P36507 5605 19p13.3 human T394-p 452289 LRLNQPGtPTRTAV_ phosphorylation; enzymatic activity, induced 33226073 3 56 62 induces ERK1/2 phosphorylation -ZAP70 ZAP70 EC 2.7.10.2; KINASE; Kinase, protein; Protein kinase, TK; Protein kinase, tyrosine (non-receptor) P43403 7535 2q11.2 human Y598-p 464392 QRMRACYySLASKVE enzymatic activity, altered transcription, altered 9624129 1 1 173 -MRE11 MRE11A Cell cycle regulation; DNA repair, damage; DNA-binding; Deoxyribonuclease P49959 4361 11q21 human T481-p 11506400 VKYQLEKtQRFLKER molecular association, regulation DNA(DISRUPTS) 19709933 1 0 0 -INSR INSR EC 2.7.10.1; KINASE; Kinase, protein; Membrane protein, integral; Protein kinase, TK; Protein kinase, tyrosine (receptor) P06213 3643 19p13.2 human Y992-p 451597 DGPLGPLyASSNPEY enzymatic activity, inhibited 8024702 3 0 0 -PPP1R12A MYPT1 Motility/polarity/chemotaxis; PHOSPHATASE; Protein phosphatase, regulatory subunit O14974 4659 12q21.2-q21.31 human S473-p 3174680 GVTRSASsPRLSSSL molecular association, regulation; enzymatic activity, inhibited cell cycle regulation PPP2R2C(DISRUPTS); PPP2R3B(INDUCES); PPP2R5C(DISRUPTS); PPP2R3A(INDUCES) 32900880 2 9 7 -Itpr1 IP3R1 Channel, calcium; Channel, ligand-gated; Membrane protein, integral; Membrane protein, multi-pass P11881 16438 6 E1|6 49.74 cM mouse T799-p 450269 RDPQEQVtPVKYARL activity, induced 26259730 4 0 0 enhance Ca2+ oscillations, enhance the sensitivity of IP3R1 -NEK11 NEK11 EC 2.7.11.1; KINASE; Kinase, protein; Nucleolus; Protein kinase, Other; Protein kinase, Ser/Thr (non-receptor) Q8NG66 79858 3q22.1 human S273-p 10433801 SMLNKNPsLRPSAIE Pkinase enzymatic activity, induced 19734889 1 0 0 -MED12 MED12 Nuclear receptor co-regulator; Transcription, coactivator/corepressor Q93074 9968 Xq13.1 human R1912-m2 15381293 VPQGQRLrQQLQQSQ Med12-PQL molecular association, regulation transcription, inhibited DNA(INDUCES) 26601288 1 1 14 p21/WAF1 transcription -Ulk1 ULK1 Autophagy; EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, Other; Protein kinase, Ser/Thr (non-receptor) O70405 22241 5|5 F mouse S405-p 23070960 HGRTPSPsPTCSSSP molecular association, regulation; phosphorylation; enzymatic activity, induced carcinogenesis, induced; autophagy, induced LC3B(INDUCES); GABARAPL1(INDUCES) 33654220 1 0 1 induces phosphorylation of itself at the other site and of BECN1 and ATG13 -Elk1 ELK1 DNA-binding; Transcription factor P41969 13712 X A1.3|X 16.45 cM mouse T418-p 452139 ISVDGLStPVVLSPG molecular association, regulation transcription, inhibited Trap100(DISRUPTS); MED23(DISRUPTS); MED16(DISRUPTS) 27738173 8 0 1 -ACTN4 ACTN4 Cytoskeletal; Motility/polarity/chemotaxis O43707 81 19q13.2 human Y11-p 397383606 YHAANQSyQYGPSSA molecular association, regulation cell motility, inhibited ACTB(DISRUPTS) 29274473 1 0 0 slightly decreases binding; enhances invasion of melanoma cell line; decreases the susceptibility to m-calpain cleavage -ISCU ISCU Mitochondrial Q9H1K1 23479 12q23.3 human S14-p 469833 FRLRRAAsALLLRSP protein stabilization; molecular association, regulation 14-3-3 beta(INDUCES) 21725060; 23508953 2 51 95 -Ghr GH receptor Membrane protein, integral; Receptor, cytokine P16310 25235 2q16 rat Y594-p 450480 DAEPVPDyTTVHTVK GHBP molecular association, regulation SHP-2(INDUCES) 10976913 3 1 0 Major SHP-2 interacting phosphorylation site. GHR-bound SHP-2 negatively regulates GHR/JAK2 and STAT5B signaling. -Cttn Cortactin Actin-binding; Cytoskeletal; Motility/polarity/chemotaxis Q60598 13043 7|7 F5 mouse K107-ac 36298743 VGHEYQSkLSKHCSQ HS1_rep molecular association, regulation; acetylation; intracellular localization DIP2A(INDUCES) 31600191 1 1 4 DIP2A regulates spine morphology and synaptic transmission through acetylation of cortactin; Interaction of DIP2A-cortactin is required for acetylated cortactin; acetylation mimetic cortactin rescues the repetitive behaviors in Dip2a KO mice; acetylation alleviated abnormal PSD95 clustering at the spine head in DIP2A KO neurons -BRCA2 BRCA2 DNA repair, damage; Nuclear receptor co-regulator; Tumor suppressor P51587 675 13q13.1 human T77-p 15418117 SYNQLAStPIIFKEQ molecular association, regulation cell cycle regulation PLK1(INDUCES); RAD51(INDUCES) 24448238; 24835992 2 1 4 -RPS15 RPS15 RNA-binding; Ribosomal P62841 6209 19p13.3 human T136-p 18913279 GRPGIGAtHSSRFIP translation, induced 24725412 1 3 0 neuronal degeneration; cap-dependent and cap-independent reporter translation -SNRPB snRNP B1 RNA processing; RNA splicing; RNA-binding; Spliceosome P14678 6628 20p13 human R181-m2 1308900 GPPPPMGrGAPPPGM molecular association, regulation SMN(INDUCES) 11720283 1 1 4 -RBM17 RBM17 RNA splicing; RNA-binding; Spliceosome Q96I25 84991 10p15.1 human S291-p 27936102 EKDASKKsDSNPLTE molecular association, regulation; phosphorylation cell motility, induced RNA(DISRUPTS) 23519612 1 2 0 induced cell invasion, enhanced Cortactin phosphorylation at ERK-dependent sites -HIF1A HIF1A Autophagy; DNA-binding; Transcription factor Q16665 3091 14q23.2 human S692-p 56589702 PRSPNVLsVALSQRT protein stabilization transcription, induced 27245613; 27245614 2 2 0 -STXBP5L STXBP5L Q9Y2K9 9515 3q13.33 human S766-p 25755182 PTSQSCSsGKRLSSA protein degradation 25002582 1 1 1 ; in a multiple residue S->D mutant -Grik5 GluR KA2 Channel, ligand-gated; Membrane protein, integral; Membrane protein, multi-pass Q63273 24407 1q21 rat S833-p 31033003 FIWSTRRsAESEEVS activity, induced 23066089 1 0 0 GluR KA2 mediated potentiation of heteromeric KARs -PSEN2 PSEN2 Cell surface; EC 3.4.23.-; Membrane protein, integral; Membrane protein, multi-pass; Protease P49810 5664 1q42.13 human S19-p 449962 EVCDERTsLMSAESP molecular association, regulation AP1G1(DISRUPTS) 27293189 2 1 0 -FYB2 ARAP Adaptor/scaffold Q5VWT5 199920 1p32.2 human Y587-p 56614903 KSQEVIIyDDVDLSE molecular association, regulation; intracellular localization signaling pathway regulation SLP76(INDUCES) 27335501 1 0 0 -YAP1 YAP1 Oncoprotein; Transcription, coactivator/corepressor P46937 10413 11q22.1 human S381-p 3190669 LRTMTTNsSDPFLNS protein degradation; ubiquitination; activity, inhibited carcinogenesis, altered; carcinogenesis, inhibited; cell growth, inhibited; cell motility, inhibited; cell growth, induced; cell motility, altered; transcription, inhibited; cell growth, altered 26265440; 28416665; 35210364; 36598329 11 6 0 -POU3F2 Oct7 DNA-binding; Motility/polarity/chemotaxis; Transcription factor P20265 5454 6q16.1 human S360-p 486486 RKRKKRTsIEVSVKG Homeodomain transcription, altered DNA(DISRUPTS) 17543985 3 1 0 Phosphorylation reduced binding to NORE and PORE, but not MORE motifs. -Csnk1d CK1D EC 2.7.11.1; EC 2.7.11.26; KINASE; Kinase, protein; Protein kinase, CK1; Protein kinase, Ser/Thr (non-receptor) Q06486 64462 10q32.3 rat T329-p 31869461 ATRGLPStASGRLRG enzymatic activity, inhibited 26803658 2 2 1 -BLM BLM DNA repair, damage; DNA replication; EC 3.6.4.12; Helicase P54132 641 15q26.1 human T182-p 41290000 SHFVRVStAQKSKKG BLM_N protein degradation; ubiquitination 26028025 1 0 0 during mitosis -REEP4 REEP4 Membrane protein, integral; Membrane protein, multi-pass Q9H6H4 80346 8p21.3 human S152-p 3212556 AGRLRSFsMQDLRSI molecular association, regulation 14-3-3 beta(INDUCES) 21725060 1 68 93 mutation of this site prevents 14-3-3 binding (pan-14-3-3 antibody) -ZBTB16 PLZF C2H2-type zinc finger protein; DNA-binding; Oncoprotein; Transcription, coactivator/corepressor Q05516 7704 11q23.2 human K647-ac 50455003 PSLSSMQkHMKGHKP molecular association, regulation; acetylation; intracellular localization chromatin organization, altered; transcription, inhibited DNA(INDUCES) 26405459 1 0 0 induces histone acetylation and DNA hypermethylation -Jak2 JAK2 EC 2.7.10.2; KINASE; Kinase, protein; Oncoprotein; Protein kinase, TK; Protein kinase, tyrosine (non-receptor) Q62689 24514 1q52 rat Y1008-p 448408 LPQDKEYyKVKEPGE PK_Tyr_Ser-Thr enzymatic activity, induced 15065871 77 2 16 -Trim28 TIF1B EC 6.3.2.-; KINASE; Kinase, protein; Ligase; Nuclear receptor co-regulator; Protein kinase, atypical; SUMO LIGASE; SUMO ligase; Transcription, coactivator/corepressor; UBIQUITIN LIGASE; Ubiquitin conjugating system; Ubiquitin ligase O08629 116698 1q12 rat S825-p 460839 LPSAGLSsQELSGPG molecular association, regulation cell growth, induced; apoptosis, inhibited PCNA(INDUCES) 35799276 47 9 6 inhibits PCNA binding to CUL4A and hence its ubiquitination and degradation -RELA NFkB-p65 DNA-binding; Nuclear receptor co-regulator; Transcription factor Q04206 5970 11q13.1 human S276-p 447798 SMQLRRPsDRELSEP RHD_dimer protein degradation; acetylation; protein stabilization; molecular association, regulation; phosphorylation; activity, induced; ubiquitination; intracellular localization cell motility, induced; transcription, induced; signaling pathway regulation; transcription, altered; endocytosis, induced; cell growth, induced; apoptosis, inhibited; transcription, inhibited HDAC1(DISRUPTS); PKACA(INDUCES); RARB(INDUCES); eEF1B(INDUCES); CBP(INDUCES); RARA(INDUCES); p300(INDUCES); DNMT1(INDUCES); FBXW2(INDUCES) DNA(INDUCES) 11027313; 11931769; 12628924; 15516339; 17108032; 17114467; 17959673; 17991436; 18025230; 18362169; 18424438; 19197368; 19911008; 19933278; 20065107; 20364151; 20562110; 20639196; 21765477; 23100252; 23536830; 31574956; 31980577; 33594320; 34465889; 36264688; 36413416; 9660950 90 0 0 S276 phosphorylation inhibits interaction between N- and C-terminal domains of p65.; inhibits H3K9 acetylation -BAG3 BAG3 Apoptosis; Chaperone O95817 9531 10q26.11 human S289-p 469169 RSSTPLHsPSPIRVH molecular association, regulation; intracellular localization HSBP1(DISRUPTS) 27659916 2 46 47 -TBK1 TBK1 EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, Other; Protein kinase, Ser/Thr (non-receptor) Q9UHD2 29110 12q14.2 human S172-p 447732 EDDEQFVsLYGTEEY Pkinase molecular association, regulation; intracellular localization; phosphorylation; enzymatic activity, induced carcinogenesis, induced; cell motility, induced; transcription, induced; transcription, altered; signaling pathway regulation; DNA repair, induced; autophagy, induced; cell growth, induced; transcription, inhibited Other(INDUCES) 11839743; 21145761; 22851696; 23453972; 26376340; 27125670; 27538435; 28049762; 31332347; 31792381; 33411856; 33883226; 33990776; 34226595; 34343500; 35406696; 35868534; 36640307; 36928362 76 8 47 -Numb NUMB Cell development/differentiation Q2LC84 29419 6q24 rat S275-p 456490 EQLARQGsFRGFPAL NumbF molecular association, regulation AP2A1(DISRUPTS); AP2B1(DISRUPTS); 14-3-3 eta(INDUCES) 17022975 4 18 7 -Il2rb IL2RB Membrane protein, integral; Receptor, cytokine P16297 16185 15 E1|15 37.52 cM mouse Y367-p 455360 SCFTNQGyFFFHLPN intracellular localization 27799311 5 0 0 transport CBP from the nucleus to the cytoplasm -G6PD G6PD iso3 Carbohydrate Metabolism - pentose phosphate pathway; Cell development/differentiation; EC 1.1.1.49; Other Amino Acids Metabolism - glutathione; Oxidoreductase P11413-3 2539 Xq28 human T266-p 15207800 NIACVILtFKEPFGT G6PD_C enzymatic activity, induced 20649491 1 0 0 -CDK1 CDK1 Cell cycle regulation; EC 2.7.11.22; EC 2.7.11.23; KINASE; Kinase, protein; Motility/polarity/chemotaxis; Protein kinase, CMGC; Protein kinase, Ser/Thr (non-receptor) P06493 983 10q21.2 human T14-p 447608 IEKIGEGtYGVVYKG Pkinase intracellular localization; enzymatic activity, inhibited; phosphorylation cell cycle regulation; carcinogenesis, induced; cell growth, induced; transcription, induced 10504341; 11782384; 12912980; 1532335; 20360007; 21602434; 21900495; 34370741; 35444283; 35738066; 36163549; 8441405; 9268380 34 117 1764 -HSF1 HSF1 DNA-binding; Transcription factor Q00613 3297 8q24.3 human S344-p 455485 ESEPAPAsVTALTDA Vert_HS_TF transcription, inhibited 25963659 2 4 1 under non-stressed conditions, upon heat shock S to A mutant showed 60% higher luciferase activity -LTB4R2 LTB4R2 GPCR, family 1; Membrane protein, integral; Membrane protein, multi-pass; Motility/polarity/chemotaxis; Receptor, GPCR Q9NPC1 56413 14q12 human T324-p 12267086 GGRSREGtMELRTTP TM molecular association, regulation cell motility, induced RANBP9(DISRUPTS) 22044535; 23928309 2 0 0 -NCF1 p47phox EC 1.-.-.-; Oxidoreductase P14598 653361 7q11.23 human S315-p 451725 AHSIHQRsRKRLSQD NECFESHC molecular association, regulation; enzymatic activity, induced signaling pathway regulation CYBA(INDUCES) 12056906; 31736979; 35108370 14 0 0 LPS-induced activation of p38MAPK and ERK1/2 signaling pathways -STAT5B STAT5B DNA-binding; Oncoprotein; Transcription factor P51692 6777 17q21.2 human Y699-p 448198 TAKAVDGyVKPQIKQ activity, induced; molecular association, regulation; phosphorylation cell cycle regulation; transcription, induced; transcription, altered Bcr(INDUCES); Hck(INDUCES) DNA(INDUCES) 11751923; 12411494; 16772534; 16862179; 17822672; 17997837; 18430728; 18550772; 23980167 45 45 2242 increases pSTAT5B at Y699 -DEPTOR DEPTOR Apoptosis Q8TB45 64798 8q24.12 human S286-p 21697912 SSMSSCGsSGYFSSS protein degradation; molecular association, regulation; ubiquitination BTRC(INDUCES); FBW1B(INDUCES) 22017875; 22017876; 22017877 3 1 0 -Ryr2 RYR2 Channel, ligand-gated; Membrane protein, integral; Membrane protein, multi-pass; Transporter; Transporter, ion channel E9Q401 20191 13 A1|13 4.38 cM mouse S2807-p 448848 YNRTRRIsQTSQVSI activity, induced; molecular association, regulation exocytosis, altered FKBP1B(DISRUPTS) 16407108; 20615971; 22939628 57 5 3 calcium release, cardiomyopathy and increased mortality in mdx mice; stress-induced cognitive dysfunction; RyR2 S2808A mutation in mice improves cardiac functions after myocardial infarction; Stress induced calcium leak in channels -Gabrg2 GABRG2 Channel, chloride; Channel, ligand-gated; Membrane protein, integral; Membrane protein, multi-pass; Transporter; Transporter, ion channel Q6PW52 29709 10q21 rat S381-p 452033 NPLLRMFsFKAPTID Neur_chan_memb intracellular localization 15235089 4 3 2 -Alx1 Cart1 DNA-binding Q63087 25401 7q21 rat K131-ac 459028 DSNVSSSkKRRHRTT transcription, induced 12929931 1 0 0 -Ppp1r9a neurabin 1 Adaptor/scaffold; Protein phosphatase, regulatory subunit O35867 84685 4q13 rat S461-p 455523 ANRKIKFsCAPIKVF PDZ_5 molecular association, regulation; receptor internalization, inhibited p70S6K(INDUCES); PPP1CA(INDUCES); PPP1CA(DISRUPTS) 12052877; 29383693 3 0 1 interferes with LTD induction -MRAS MRas G protein; G protein, monomeric; G protein, monomeric, Ras; Oncoprotein O14807 22808 3q22.3 human K127-ub 1879723002 PMILVANkVDLMHLR protein degradation 31337872 1 0 0 other residues may be involved in degradation -Pde5a PDE5A EC 3.1.4.35; Nucleotide Metabolism - purine; Phosphodiesterase Q8CG03 242202 3|3 G1 mouse S92-p 448178 GAPARKIsASEFDRP cell adhesion, induced 35767715 8 6 0 -CBLB Cbl-b Adaptor/scaffold; Calcium-binding; EC 6.3.2.-; Ligase; UBIQUITIN LIGASE; Ubiquitin conjugating system; Ubiquitin ligase Q13191 868 3q13.11 human Y665-p 451550 GHLGSEEyDVPPRLS molecular association, regulation CRKL(INDUCES) 10022120 3 6 117 in vitro and vivo; Y709 is major binding site, and to lesser extent Y665 -NCL NCL DNA-binding; Helicase; Nuclear receptor co-regulator; Nucleolus; RNA-binding P19338 4691 2q37.1 human S206-p 466007 DDDEEDDsEEEAMET intracellular localization cell cycle regulation; cell growth, induced 25313645 2 24 36 -FOXO1 FOXO1A DNA-binding; Nuclear receptor co-regulator; Oncoprotein; Transcription factor Q12778 2308 13q14.11 human S276-p 1253812002 RAAKKKAsLQSGQEG protein stabilization; intracellular localization 30201683 4 1 0 -Cebpb C/EBP-beta DNA-binding; Motility/polarity/chemotaxis; Transcription factor P21272 24253 3q42 rat K217-ac 458940 PAKAKAKkAVDKLSD transcription, inhibited 24344329 4 1 0 -Sh2b1 SH2-B-beta Adaptor/scaffold Q62985 89817 1q36 rat Y494-p 448754 VHPLSTPyPPLDTPE cell motility, induced; cytoskeletal reorganization 12551917; 23444381 2 0 0 membrane ruffling; macrophage migration -IGF2BP1 IGF2BP1 RNA-binding; Translation Q9NZI8 10642 17q21.32 human S181-p 453893 RGQPRQGsPVAAGAP carcinogenesis, induced; apoptosis, inhibited; RNA stability, induced; translation, inhibited 33388443 3 59 12 -ADD1 ADD1 Cytoskeletal; Motility/polarity/chemotaxis P35611 118 4p16.3 human T480-p 449481 TKEDGHRtSTSAVPN activity, induced 10209029 1 1 0 phosphorylation of this site by Rho-kinase regulates membrane ruffling and cell motility. -INSR INSR EC 2.7.10.1; KINASE; Kinase, protein; Membrane protein, integral; Protein kinase, TK; Protein kinase, tyrosine (receptor) P06213 3643 19p13.2 human S1217-p 3103702 DGVFTTSsDMWSFGV PK_Tyr_Ser-Thr enzymatic activity, induced 10866039 1 0 0 -FUNDC1 FUNDC1 Membrane protein, multi-pass; Mitochondrial Q8IVP5 139341 Xp11.3 human S17-p 2025377 DYESDDDsYEVLDLT activity, induced; molecular association, regulation; protein conformation carcinogenesis, induced; autophagy, induced LC3B(INDUCES); LC3A(INDUCES) 24671035; 27757847; 36425056; 36927870 6 7 0 selective mitophagy; induces mitophagy; Mitophagy induced -DDX39A DDX39 EC 3.6.4.13; Helicase; RNA splicing; RNA-binding O00148 10212 19p13.12 human K154-sm 55429506 FFGGLSIkKDEEVLK DEAD molecular association, regulation RNA(DISRUPTS) 32393512 1 3 0 -MEGF10 MEGF10 Membrane protein, integral Q96KG7 84466 5q23.2 human Y1030-p 12186245 LSSSENPyATIKDPP molecular association, regulation cell growth, induced Notch 1(INDUCES) 23954233; 28498977 2 0 1 -Myocd myocardin Cell development/differentiation; Transcription factor Q8VIM5 214384 11|11 B3 mouse T893-p 10791203 TMEWLDLtPPSSTPG molecular association, regulation transcription, inhibited CBP(DISRUPTS) 19776005 1 0 0 -DLC1 DLC1 GAP; GAP, Rac/Rho; Tumor suppressor Q96QB1 10395 8p22 human S735-p 15499997 MVRKRSVsNSTQTSS molecular association, regulation; intracellular localization; protein conformation; activity, inhibited cell growth, induced RHOA(DISRUPTS); DLC1(INDUCES) 29114068 1 2 1 greatly attenuates its RhoGAP and tumor-suppressor functions; becomes monomer; alters its focal adhesion (FA) localization -BCL2 Bcl-2 Apoptosis; Autophagy; Membrane protein, integral; Oncoprotein P10415 596 18q21.33 human T69-p 448398 SRDPVARtSPLQTPA molecular association, regulation apoptosis, altered; apoptosis, induced; apoptosis, inhibited BAX(INDUCES); beclin 1(DISRUPTS); p53(DISRUPTS) 15703383; 16738310; 17097560; 18570871; 19029119; 34064109 11 0 0 -Becn1 beclin 1 Adaptor/scaffold; Autophagy; Membrane protein, peripheral O88597 56208 11|11 D mouse K414-ac 1881258602 SGGSYSIkTQFNSEE autophagy, induced; cell differentiation, induced 34085745 1 0 0 adipocyte differentiation, induces lipolysis -Chpt1 CHPT1 EC 2.7.8.2; Lipid Metabolism - ether lipid; Lipid Metabolism - glycerophospholipid; Membrane protein, integral; Membrane protein, multi-pass; Transferase Q8C025 212862 10|10 C1 mouse K284-ub 12718509 LAIMIYKkSATNMFE protein degradation; enzymatic activity, inhibited 20018880 1 0 0 -RAD51 RAD51 DNA repair, damage; Mitochondrial Q06609 5888 15q15.1 human K338-ac 1873284316 ADGVGDAkD______ DNA repair, inhibited 28869605 1 0 0 -SMCR8 SMCR8 Unknown function Q8TEV9 140775 17p11.2 human S402-p 55469601 QDRPPSSsLEECPIP autophagy, induced 27103069 1 0 0 -PINX1 PINX1 Inhibitor; Nucleolus; Tumor suppressor Q96BK5 54984 8p23.1 human T141-p 14823403 DLSSRSKtDLDCIFG protein degradation; ubiquitination 20573420 1 2 0 -BCL2L12 Bcl-2L12 Apoptosis Q9HB09 83596 19q13.33 human S156-p 9258022 SESPRPCsLPIRPCY protein conformation autophagy, induced; apoptosis, inhibited 22262180; 29749471 2 0 7 -KDR VEGFR2 EC 2.7.10.1; KINASE; Kinase, protein; Membrane protein, integral; Protein kinase, TK; Protein kinase, tyrosine (receptor) P35968 3791 4q12 human Y1059-p 447900 DIYKDPDyVRKGDAR PK_Tyr_Ser-Thr molecular association, regulation; receptor internalization, altered; phosphorylation; enzymatic activity, induced cell cycle regulation; cell differentiation, altered; cell growth, induced; cell growth, altered Src(INDUCES); PLCG1(INDUCES); CBL(INDUCES) 10102632; 11435426; 16891660; 16946136; 17372230; 19050761 16 3 110 -HTT Huntingtin Cytoskeletal P42858 3064 4p16.3 human K6-sm 8545504 __MATLEkLMKAFES protein stabilization; intracellular localization transcription, inhibited 15064418 2 0 0 -Dok1 DOK1 Adaptor/scaffold; Motility/polarity/chemotaxis P97465 13448 6 C3|6 35.94 cM mouse Y361-p 448367 DSKEDPIyDEPEGLA molecular association, regulation cell growth, inhibited; cytoskeletal reorganization RASA1(INDUCES); NCK1(INDUCES) 10202139; 12087092; 15148308; 25043303 9 27 497 -Nox1 NOX1 Channel, misc.; EC 1.-.-.-; Membrane protein, integral; Membrane protein, multi-pass; Motility/polarity/chemotaxis; Oxidoreductase Q9WV87 114243 Xq32 rat T429-p 36552501 RAHNKLKtQKIYFYW NAD_binding_6 molecular association, regulation; enzymatic activity, induced cell motility, induced NOXA1(INDUCES) 25228390 1 1 0 NADPH oxidase activity induced, ROS production increased, Cell migration induced -Mybpc3 MYBPC3 Myosin-binding O70468 17868 2|2 E1 mouse S302-p 471081 SLLKKRDsFRRDSKL activity, induced; molecular association, regulation; intracellular localization; protein conformation apoptosis, altered; cytoskeletal reorganization MYBPC1(DISRUPTS) 17075052; 21978630; 22752314; 24951619; 25740838; 26908877; 28167762; 28345052 28 6 0 phosphorylation weakens this stabilization and binding of the heads to the backbone, increasing the probability of their interacting with the thin filament -PIP4K2A PIP4K2A Carbohydrate Metabolism - inositol phosphate; EC 2.7.1.149; Kinase, lipid; Motility/polarity/chemotaxis P48426 5305 10p12.2 human T376-p 460716 KAAHAAKtVKHGAGA PIP5K enzymatic activity, inhibited 16563698 1 0 0 -Ppargc1b PGC-1 beta Nuclear receptor co-regulator; Transcription, coactivator/corepressor Q8VHJ7 170826 18|18 E1 mouse K455-ac 7761212 EEEEWGRkRPGRGLP intracellular localization transcription, inhibited 19491097 1 1 0 -Dlg1 DLG1 Adaptor/scaffold; Motility/polarity/chemotaxis Q811D0 13383 16 B2|16 22.4 cM mouse Y222-p 35530400 GTDADYEyEEITLER MAGUK_N_PEST phosphorylation transcription, induced; signaling pathway regulation 25098293 1 0 0 p38A phosphorylation, TCR-dependent signaling pathway -Rps6 S6 Translation P62755 29304 5q32 rat S236-p 448093 AKRRRLSsLRASTSK signaling pathway regulation 21949366 239 72 1124 -DAZAP1 DAZAP1 Motility/polarity/chemotaxis; RNA-binding Q96EP5 26528 19p13.3 human T269-p 467204 FTSYIVStPPGGFPP molecular association, regulation DAZ1(DISRUPTS) 16848763 1 0 0 -ITGB1 ITGB1 Cell adhesion; Cell surface; Membrane protein, integral; Motility/polarity/chemotaxis; Receptor, misc. P05556 3688 10p11.22 human T788-p 448600 PIYKSAVtTVVNPKY Integrin_b_cyt activity, induced; molecular association, regulation; protein conformation cell adhesion, induced; cell motility, altered; cell adhesion, altered FLNA(DISRUPTS); kindlin-2(DISRUPTS); talin 1(DISRUPTS) 14660602; 15949469; 16405888; 19115199; 33119040 15 2 1 -SUFU SUFU Adaptor/scaffold; Transcription, coactivator/corepressor; Tumor suppressor Q9UMX1 51684 10q24.32 human K257-ub 5009206 HLQERVDkGIETDGS SUFU_C protein degradation cell growth, induced; transcription, induced 18997815 1 1 0 -SLC12A1 NKCC2 Membrane protein, integral; Membrane protein, multi-pass; Transporter; Transporter, SLC family Q13621 6557 15q21.1 human T100-p 458227 TNTYYLQtFGHNTMD AA_permease_N signaling pathway regulation 21321328 15 2 0 WNK-SPAK-OSR1 pathway -Raf1 RAF1 EC 2.7.11.1; KINASE; Kinase, protein; Oncoprotein; Protein kinase, Ser/Thr (non-receptor); Protein kinase, TKL Q99N57 110157 6 E3|6 53.62 cM mouse Y341-p 447750 GQRDSSYyWEIEASE phosphorylation; enzymatic activity, induced apoptosis, altered 10205168; 11296227; 17535812 35 1 1 Bad Ser 112 + 136 phosphorylation -ETS2 Ets-2 DNA-binding; Oncoprotein; Transcription factor P15036 2114 21q22.2 human S248-p 54126001 KSRLSSVsVTYCSVS Ets1_N_flank protein degradation 26871468 1 0 0 CDK10 mediated degradation -AURKA AurA EC 2.7.11.1; KINASE; Kinase, protein; Oncoprotein; Protein kinase, Other; Protein kinase, Ser/Thr (non-receptor) O14965 6790 20q13.2 human R304-me 1881955600 PPEMIEGrMHDEKVD enzymatic activity, induced 37370099 1 0 0 -BCAT2 BCAT2 Amino Acid Metabolism - valine, leucine and isoleucine biosynthesis; Amino Acid Metabolism - valine, leucine and isoleucine degradation; Cofactor and Vitamin Metabolism - pantothenate and CoA biosynthesis; EC 2.6.1.42; Mitochondrial; Transferase O15382 587 19q13.33 human K229-ub 21129876 VGGVGNYkLGGNYGP Aminotran_4 protein degradation; enzymatic activity, induced cell growth, induced 35663242 1 1 0 -YAP1 YAP1 iso2 Oncoprotein; Transcription, coactivator/corepressor P46937-2 10413 11q22.1 human S384-p 9764918 SRDESTDsGLSMSSY ubiquitination carcinogenesis, inhibited BTRC(INDUCES) 20048001 2 8 0 -CLDN11 Claudin-11 Cell adhesion; Membrane protein, integral; Membrane protein, multi-pass O75508 5010 3q26.2 human Y192-p 478786 FGENRFYyTAGSSSP molecular association, regulation cell motility, altered Src(INDUCES) 30664792 1 4 71 -PRPS1 PRPS1 Carbohydrate Metabolism - pentose phosphate pathway; EC 2.7.6.1; Kinase, other; Nucleotide Metabolism - purine P60891 5631 Xq22.3 human S285-p 1874748500 EDKMKHCsKIQVIDI Pribosyl_synth protein degradation; molecular association, regulation; ubiquitination carcinogenesis, inhibited; cell growth, inhibited TRAF2(INDUCES) 34465890 1 1 0 -XRCC1 XRCC1 DNA repair, damage P18887 7515 19q13.31 human T519-p 451450 EDPYAGStDENTDSE molecular association, regulation; intracellular localization PARP1(DISRUPTS); APTX(INDUCES); Pnk1(INDUCES) 15066279; 15367657; 25477519 3 5 5 -TUBG1 TUBG1 Cytoskeletal; Motility/polarity/chemotaxis P23258 7283 17q21.2 human S131-p 10045600 READGSDsLEGFVLC Tubulin intracellular localization cell cycle regulation 19648910 2 1 0 regulates centrosome biogenesis and homeostasis -CAST calpastatin Inhibitor P20810 831 5q15 human S655-p 25733148 QDPIDALsGDLDSCP activity, induced 29581866 1 5 1 -Emd emerin Cytoskeletal; Membrane protein, integral O08579 13726 X A7.3|X 37.92 cM mouse Y75-p 451787 AAVDSDMyDLPKKED cell motility, induced; transcription, induced; cytoskeletal reorganization 24609268 3 12 110 Y75F and Y96F had reduced expression of vinculin and SRF.; mechanical adaptation of isolated nuclei to force -MAD2L1 MAD2L1 Cell cycle regulation Q13257 4085 4q27 human S185-p 4326275 SEEVRLRsFTTTIHK HORMA intracellular localization; protein conformation 21041666; 23454898 2 3 1 -Prkcd PKCD EC 2.7.11.13; KINASE; Kinase, protein; Nuclear receptor co-regulator; Protein kinase, AGC; Protein kinase, Ser/Thr (non-receptor); Protein kinase, tyrosine (non-receptor); Tumor suppressor P09215 170538 16p16 rat S130-p 3194429 EDGDCKQsMRSEEEA phosphorylation; enzymatic activity, induced 26546672 1 10 1 downregulates phosphorylation of S357 -SNAI1 Snail1 C2H2-type zinc finger protein; Transcription factor O95863 6615 20q13.13 human K234-ub 231166703 LQTHSDVkKYQCQAC protein stabilization 28892081 1 0 0 metastasis -AMOT AMOT Q4VCS5 154796 Xq23 human K481-ub 40323316 EAYENLVkSSSKREA protein stabilization; ubiquitination; intracellular localization cell growth, inhibited 23564455 1 2 0 plasma membrane localization, induces YAP2 ubiquitination -KAT5 Tip60 ACETYLTRANSFERASE; Acetyltransferase; EC 2.3.1.48; Nuclear receptor co-regulator; Nucleolus Q92993 10524 11q13.1 human S90-p 448827 LPGSRPGsPEREVPA acetylation; protein stabilization; intracellular localization; enzymatic activity, induced; phosphorylation cell cycle regulation; DNA repair, induced; transcription, altered 16103124; 21658600; 26829474; 30297459 5 35 16 -MAP2 MAP2 Cytoskeletal; Motility/polarity/chemotaxis P11137 4133 2q34 human S1782-p 456422 GAEIITQsPGRSSVA molecular association, regulation; intracellular localization; protein conformation cytoskeletal reorganization; translation, inhibited TUBA1A(INDUCES); ACTB(INDUCES) 11029056; 33526823 2 63 14 reduce microtubule binding -NSD2 WHSC1 Amino Acid Metabolism - lysine degradation; EC 2.1.1.43; METHYLTRANSFERASE; Methyltransferase; Methyltransferase, protein lysine; Oncoprotein; Ubiquitin conjugating system O96028 7468 4p16.3 human S56-p 12667955 SKAQLSSsLQEGVMQ protein stabilization; ubiquitination; methylation carcinogenesis, induced; transcription, altered 35389552 1 4 0 inhibits ubiquitination of itself and induces methylation of histone -TP53BP1 53BP1 DNA repair, damage; Transcription, coactivator/corepressor Q12888 7158 15q15.3 human K1690-ub 40212810 GRKSATVkPGAVGAG DNA repair, induced 23874665 1 0 0 -TERT TERT DNA-binding; EC 2.7.7.49; Nucleolus; Transferase O14746 7015 5p15.33 human T249-p 1868023600 AAPEPERtPVGQGSW molecular association, regulation; enzymatic activity, induced carcinogenesis, induced; cell growth, induced; transcription, altered RNA(INDUCES) 32214089 2 1 0 induces RdRP activity, and binding to FOXO4 and RMRP RNA, reducing their transcription, alters transcription of other proteins -DDX5 DDX5 EC 3.6.4.13; Helicase; Nuclear receptor co-regulator; Nucleolus; RNA splicing; RNA-binding; Spliceosome P17844 1655 17q23.3 human K53-sm 12004408 WNLDELPkFEKNFYQ protein stabilization; molecular association, regulation chromatin organization, altered; transcription, induced; transcription, inhibited HDAC1(INDUCES) 17369852; 19995069 3 3 0 transcription of an estrogen response element -NACA NACA iso1 Motility/polarity/chemotaxis; Transcription, coactivator/corepressor Q13765 4666 12q13.3 human T174-p 3195872 EEEEVDEtGVEVKDI HYPK_UBA intracellular localization; activity, inhibited cell differentiation, inhibited; transcription, inhibited 30948508 1 10 1 -Nfatc1 NFAT2 DNA-binding; Transcription factor O88942 18018 18 E3|18 53.66 cM mouse K613-ac 9908948 SYPVIGGkKMVLSGH RHD_dimer protein stabilization; phosphorylation 32696520 1 0 1 hypoacetylation, induced higher phosphorylation, induces hair loss (regulated by Sirt7) -EPOR EPOR Membrane protein, integral; Receptor, cytokine P19235 2057 19p13.2 human Y504-p 449885 AEPLPPSyVACS___ apoptosis, inhibited 14662339 9 0 0 -ARHGAP35 GRF-1 GAP; GAP, Rac/Rho; Motility/polarity/chemotaxis; Transcription factor; Tumor suppressor Q9NRY4 2909 19q13.32 human Y1087-p 449570 DGFDPSDyAEPMDAV RhoGAP_pG1_pG2 molecular association, regulation cell motility, induced RASA1(INDUCES) 30664792; 32540970 4 38 1052 -PLA2G4A PLA2G4A EC 3.1.1.4; EC 3.1.1.5; Lipid Metabolism - alpha-linolenic acid; Lipid Metabolism - arachidonic acid; Lipid Metabolism - ether lipid; Lipid Metabolism - glycerophospholipid; Lipid Metabolism - linoleic acid; Phospholipase P47712 5321 1q31.1 human T268-p 3190702 HNPLLLLtPQKVKRY PLA2_B intracellular localization; protein conformation; enzymatic activity, induced 36351818 1 12 0 -AKT1S1 PRAS40 Apoptosis Q96B36 84335 19q13.33 human S221-p 2506802 DLDRIAAsMRALVLR PRAS molecular association, regulation; activity, inhibited 14-3-3 beta(INDUCES) 18372248 2 4 3 -APC APC Motility/polarity/chemotaxis; Tumor suppressor P25054 324 5q22.2 human S1360-p 3188801 EFSSGAKsPSKSGAQ APC_u9 cell cycle regulation 19703905 1 19 0 important for mitotic spindle anchoring to the cell cortex and orientation -SIGLEC10 Siglec-10 Cell adhesion; Membrane protein, integral Q96LC7 89790 19q13.41 human Y667-p 450087 ESQEELHyATLNFPG molecular association, regulation SHP-2(INDUCES); SHP-1(INDUCES) 11733002; 12163025 2 1 1 -Rb1 Rb Nuclear receptor co-regulator; Oncoprotein; Transcription, coactivator/corepressor; Tumor suppressor P13405 19645 14 38.73 cM|14 D3 mouse S243-p 447975 AAIPINGsPRTPRRG molecular association, regulation E2F1(DISRUPTS) 10207050; 35023164 19 45 86 -Map4k1 HPK1 EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, STE; Protein kinase, Ser/Thr (non-receptor) P70218 26411 7|7 B1 mouse S171-p 455474 ATLARRLsFIGTPYW Pkinase enzymatic activity, induced 17895239 3 1 13 -FOS Fos DNA-binding; Motility/polarity/chemotaxis; Oncoprotein; Transcription factor P01100 2353 14q24.3 human Y10-p 473043 FSGFNADyEASSSRC intracellular localization cell cycle regulation; cell growth, inhibited 17160021; 22105363 2 0 0 critical for association of Fos with endoplasmic reticulum membranes and phospholipid synthesis activation; inhibits phospholipid synthesis -AHR AHR DNA-binding; Transcription factor P35869 196 7p21.1 human S436-p 1874101916 LRTKNGTsGKDSATT protein degradation; ubiquitination autophagy, induced; transcription, induced 34198826 1 0 0 -STXBP1 STXBP1 Vesicle P61764 6812 9q34.11 human T574-p 454395 IGSTHILtPQKLLDT Sec1 exocytosis, inhibited 15273248 3 0 0 -CENPA CENPA DNA-binding P49450 1058 2p23.3 human K124-ac 1872903202 GRVTLFPkDVQLARR Histone molecular association, regulation cell cycle regulation CENPC1(DISRUPTS) 28396698 1 1 0 regulates timing timing of centromeric replication -NF2 Merlin Cytoskeletal; Motility/polarity/chemotaxis; Tumor suppressor P35240 4771 22q12.2 human K76-sm 31089523 KDTVAWLkMDKKVLD FERM_N protein stabilization; molecular association, regulation; intracellular localization carcinogenesis, inhibited; signaling pathway regulation Akt1(INDUCES) 24166499 1 0 0 refgulation of PI3K/Akt signaling -Cacna1b CACNA1B Channel, calcium; Membrane protein, integral; Membrane protein, multi-pass Q02294 257648 3p13 rat S425-p 465547 KRAATKKsRNDLIHA activity, inhibited 16704976; 19167461 2 1 0 -DLC1 DLC1 GAP; GAP, Rac/Rho; Tumor suppressor Q96QB1 10395 8p22 human S1004-p 34490415 RHRLRWHsFQSSHRP molecular association, regulation; intracellular localization; protein conformation; activity, inhibited cell growth, induced RHOA(DISRUPTS); DLC1(INDUCES) 29114068 1 1 0 greatly attenuates its RhoGAP and tumor-suppressor functions; becomes monomer; alters its focal adhesion (FA) localization -Cd274 PD-L1 Membrane protein, integral Q9EP73 60533 19|19 C1 mouse Y112-p 1015586 KLQDAGVyCCIISYG V-set carcinogenesis, induced; cell growth, induced 31305264 1 1 0 enhances the cancer immune escape -PBK PBK Cancer Testis Antigen (CTA); EC 2.7.12.2; KINASE; Kinase, protein; Protein kinase, Other; Protein kinase, Ser/Thr (non-receptor); Protein kinase, dual-specificity (non-receptor) Q96KB5 55872 8p21.1 human Y272-p 54400800 DFDDEAYyAALGTRP Pkinase protein stabilization; enzymatic activity, induced carcinogenesis, induced; cell motility, induced; cell growth, induced 27016416; 37016377 2 0 0 -MED12 MED12 Nuclear receptor co-regulator; Transcription, coactivator/corepressor Q93074 9968 Xq13.1 human R1862-m2 27270384 VDPYRPVrLPMQKLP Med12-PQL molecular association, regulation transcription, inhibited DNA(INDUCES) 26601288 1 1 5 p21/WAF1 transcription -KDM5A JARID1A DEMETHYLASE; Demethylase; EC 1.14.11.-; Nuclear receptor co-regulator; Nucleolus; Oxidoreductase; Transcription factor P29375 5927 12p13.33 human S225-p 36123496 TRRVKTQsESGDVSR intracellular localization 27292631 1 1 0 JARID1A recruitment to the promoters of AKT-regulated genes -BAZ1B WSTF DNA replication; EC 2.7.10.2; KINASE; Kinase, protein; Nuclear receptor co-regulator; Protein kinase, Ser/Thr (non-receptor); Protein kinase, tyrosine (non-receptor) Q9UIG0 9031 7q11.23 human K426-ac 9905197 GNSKSPKkGLKTPKT molecular association, regulation; phosphorylation; enzymatic activity, induced carcinogenesis, induced; cell growth, induced; transcription, induced H2AX(INDUCES) 32518374 1 1 1 promotes phosphorylation of WSTF at S158 -CDC25B CDC25B EC 3.1.3.48; Motility/polarity/chemotaxis; Nuclear receptor co-regulator; PHOSPHATASE; Protein phosphatase, dual-specificity P30305 994 20p13 human S151-p 7998663 FAIRRFQsMPVRLLG M-inducer_phosp molecular association, regulation 14-3-3 beta(INDUCES); 14-3-3 sigma(INDUCES); 14-3-3 epsilon(INDUCES) 21558810 3 13 26 -ZYX Zyxin Cell adhesion; Motility/polarity/chemotaxis Q15942 7791 7q34 human S142-p 460644 PQPREKVsSIDLEID molecular association, regulation; intracellular localization acinus(INDUCES); 14-3-3 gamma(INDUCES) 17572661 2 12 0 phosphorylation does not protect zyxin from proteolytic cleavage by caspase, but inhibits acinus degradation and suppresses apoptosis -Drd1 DRD1 GPCR, family 1; Membrane protein, integral; Membrane protein, multi-pass; Receptor, GPCR P18901 24316 17p14 rat S256-p 455301 NPVECAQsESSFKMS 7tm_1 receptor desensitization, altered 14660631 1 0 0 -Hcn1 HCN1 Membrane protein, integral; Membrane protein, multi-pass O88704 15165 13 D2.3|13 66.34 cM mouse S810-p 1877421604 EVRPLSAsQPSLPHE molecular association, regulation 14-3-3 zeta(INDUCES) 35679272 1 0 0 -Plk4 PLK4 EC 2.7.11.21; KINASE; Kinase, protein; Nucleolus; Protein kinase, Other; Protein kinase, Ser/Thr (non-receptor) Q64702 20873 3|3 B mouse S298-p 12654004 STTITASsGTSLSGS protein degradation; ubiquitination 20100909 2 1 0 -Snap23 SNAP23 Vesicle O09044 20619 2 60.37 cM|2 E5 mouse S120-p 455263 NVVSKQPsRITNGQP SNAP-25 protein stabilization exocytosis, altered; exocytosis, induced 18692471; 25083866; 25176657 9 2 0 granule exocytosis (mast cell degranulation); required for IKK2-mediated mast cells degranulation; stabilizes SNARE complex, important for phagosomal MHC-1 accumulation and cross-presentation -SEPTIN5 SEPT5 Cell cycle regulation; Cytoskeletal; Hydrolase; Vesicle Q99719 5413 22q11.21 human S327-p 454379 TQDSRMEsPIPILPL neural plasticity; autophagy, induced 34954322 2 27 2 -IGF1R IGF1R EC 2.7.10.1; KINASE; Kinase, protein; Membrane protein, integral; Protein kinase, TK; Protein kinase, tyrosine (receptor) P08069 3480 15q26.3 human S1313-p 2091904 DPSASSSsLPLPDRH activity, induced; phosphorylation cell differentiation, altered; apoptosis, altered; cell growth, altered 10746631; 10786694 2 0 0 observed in Y980F + S1310-1313A; ERK phosphorylation -Pten PTEN Carbohydrate Metabolism - inositol phosphate; EC 3.1.3.16; EC 3.1.3.48; EC 3.1.3.67; Motility/polarity/chemotaxis; Nuclear receptor co-regulator; PHOSPHATASE; Phosphatase, lipid; Tumor suppressor O08586 19211 19 C1|19 28.14 cM mouse S370-p 448649 TSVTPDVsDNEPDHY protein stabilization 20940307 12 7 0 -Notch3 NOTCH3 Membrane protein, integral Q61982 18131 17 B1|17 17.37 cM mouse K1692-ac 31089505 KDIAAGHkGRREPVG protein degradation; ubiquitination carcinogenesis, inhibited; cell growth, inhibited; transcription, inhibited; signaling pathway regulation 22120716 1 1 0 -Fndc5 FNDC5 Membrane protein, integral Q8K4Z2 384061 4|4 D2.2 mouse K127-ac 1881215704 KTPREAEkMASKNKD ubiquitination 33754067 1 0 0 SIRT2-dependent deacetylation and deubiquitination increases stability -Pycard PYCARD Adaptor/scaffold; Tumor suppressor Q9EPB4 66824 7|7 F3 mouse Y144-p 465096 SVLTEGQyQAVRAET CARD molecular association, regulation PYCARD(INDUCES) 35196496 4 2 4 -OPRK1 KOR-1 GPCR, family 1; Membrane protein, integral; Membrane protein, multi-pass; Receptor, GPCR P41145 4986 8q11.23 human K378-ub 1975300 RDIDGMNkPV_____ receptor internalization, induced; protein degradation 18212250 1 0 0 ubiquitination regulates but is not required for receptor downregulation -Kcnj6 GIRK2 Membrane protein, integral; Membrane protein, multi-pass P48550 25743 11q11 rat S9-p 4707737 TMAKLTEsMTNVLEG protein processing 19118198 2 1 0 regulates channel recycling to the membrane -MYL9 MRLC1 Contractile; Motility/polarity/chemotaxis P24844 10398 20q11.23 human S2-p 4964101 ______MsSKRAKAK intracellular localization cytoskeletal reorganization 22136066 5 0 0 -RPS6KA4 MSK2 EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, AGC; Protein kinase, Ser/Thr (non-receptor) O75676 8986 11q13.1 human S196-p 450046 EEKERTFsFCGTIEY Pkinase enzymatic activity, induced 10806207; 17429437 4 1 1 -Map3k3 MEKK3 EC 2.7.11.25; KINASE; Kinase, protein; Protein kinase, STE; Protein kinase, Ser/Thr (non-receptor) Q61084 26406 11|11 E1 mouse S526-p 458796 MSGTGIRsVTGTPYW Pkinase enzymatic activity, induced 14-3-3 epsilon(INDUCES) 16407301 4 2 0 interaction with 14-3-3 epsilon prevents dephosphorylation of S526. critical site for activation of ERK, p38 and JNK kinases. -RARA RARA DNA-binding; Nuclear receptor; Oncoprotein; Transcription factor P10276 5914 17q21.2 human T181-p 455328 CSESYTLtPEVGELI protein degradation; ubiquitination signaling pathway regulation 15657432; 21272161 2 0 0 retinoid signaling -AANAT AA-NAT ACETYLTRANSFERASE; Acetyltransferase; Amino Acid Metabolism - tryptophan; EC 2.3.1.87 Q16613 15 17q25.1 human T31-p 452141 PSCQRRHtLPASEFR molecular association, regulation 14-3-3 zeta(INDUCES) 28387381 4 0 0 -Ptpn2 PTPN2 EC 3.1.3.48; Motility/polarity/chemotaxis; PHOSPHATASE; Protein phosphatase, tyrosine (non-receptor) Q06180 19255 18|18 E1 mouse S52-p 23136003 RNRYRDVsPYDHSRV Y_phosphatase phosphorylation; enzymatic activity, induced carcinogenesis, induced; apoptosis, inhibited 37000627 1 4 2 dephosphorylates CD3Z -Map2 MAP2 Cytoskeletal; Motility/polarity/chemotaxis P15146 25595 9q32 rat T1622-p 450181 YSSRTPGtPGTPSYP molecular association, regulation cytoskeletal reorganization 25309320 3 21 7 fractionated with microtubules, protrusion growth, regulates basal dendrite architecture in vivo -KLF5 KLF5 C2H2-type zinc finger protein; DNA-binding; Transcription factor Q13887 688 13q22.1 human S153-p 10945600 LRTGLYKsQRPCVTH transcription, altered 12682370 1 1 0 S153A mutant moderately reduces transactivation. -Jak2 JAK2 EC 2.7.10.2; KINASE; Kinase, protein; Oncoprotein; Protein kinase, TK; Protein kinase, tyrosine (non-receptor) Q62120 16452 19 C1|19 23.73 cM mouse Y201-p 470070 DQTPLAVyNSVSYKT FERM_F2 molecular association, regulation SHP-2(INDUCES) 17027227 3 1 0 Jak2 phosphorylation mediates binding to SHP-2, which is in a complex with AT-1 -ALOX5 5-LO EC 1.13.11.34; Lipid Metabolism - arachidonic acid; Lipid Metabolism - linoleic acid; Nuclear envelope; Oxidoreductase P09917 240 10q11.21 human S524-p 452140 GMRGRKSsGFPKSVK Lipoxygenase intracellular localization; enzymatic activity, inhibited 15280375; 16230355; 26173130; 28257804 7 1 0 -Hnf4a HNF4 alpha DNA-binding; Nuclear receptor; Transcription factor P22449 25735 3q42 rat S142-p 458368 DRISTRRsSYEDSSL molecular association, regulation transcription, altered DNA(DISRUPTS) 9234678 4 4 6 -REL REL Oncoprotein; Transcription factor Q04864 5966 2p16.1 human S492-p 456135 ISDPNMLsNCSVNMM activity, induced transcription, induced 16585559 2 0 0 both site-directed S460A or previously characterized spontaneous S460N are not responsive to NIK-induced activation of transcription at the IL-2 promoter. S460N is also much less responsive to CD3- or CD3+CD28-induced transcriptional upregulation at the IL-2 promoter. -Mrtfa MKL1 Oncoprotein; Transcription, coactivator/corepressor Q8K4J6 223701 15|15 E1 mouse S487-p 4762839 VKFGSTGsTPPVSPT transcription, induced 33171330 1 5 2 regulates the expression of IL-6; regulates re-endothelialization -NOP53 GLTSCR2 Nucleolus Q9NZM5 29997 19q13.33 human S233-p 23110061 ARLHTKPsQAPAVEV Nop53 protein degradation; molecular association, regulation; intracellular localization apoptosis, induced RPL11(DISRUPTS) 27829214 1 0 1 -CD44 CD44 iso2 Cell adhesion; Membrane protein, integral; Motility/polarity/chemotaxis; Receptor, misc. P15379-2 12505 2 E2|2 54.13 cM mouse S325-p 465561 SELNGEAsKSQEMVH cell adhesion, induced 7528778 3 10 10 hyaluronate binding is diminished when this residue is mutated -HIF1A HIF1A Autophagy; DNA-binding; Transcription factor Q16665 3091 14q23.2 human K538-ub 6778620 FKLELVEkLFAEDTE protein degradation 16862177 1 5 0 -PRDX1 PRDX1 EC 1.11.1.15; Nuclear receptor co-regulator; Oxidoreductase Q06830 5052 1p34.1 human S32-p 15334103 QFKDISLsDYKGKYV AhpC-TSA protein conformation; enzymatic activity, induced apoptosis, altered 20647304 1 16 0 -Akt1 Akt1 EC 2.7.11.1; KINASE; Kinase, protein; Oncoprotein; Protein kinase, AGC; Protein kinase, Ser/Thr (non-receptor) P31750 11651 12 F1|12 61.2 cM mouse S473-p 447855 RPHFPQFsYSASGTA Pkinase_C protein degradation; acetylation; molecular association, regulation; phosphorylation; enzymatic activity, induced; activity, induced; ubiquitination; intracellular localization cell cycle regulation; carcinogenesis, induced; apoptosis, altered; cell motility, induced; RNA stability, induced; cell motility, inhibited; signaling pathway regulation; cell differentiation, altered; RNA splicing, induced; cell growth, induced; translation, induced; transcription, inhibited; cell growth, altered; carcinogenesis, inhibited; carcinogenesis, altered; cell growth, inhibited; transcription, induced; transcription, altered; neural plasticity; cell differentiation, induced; apoptosis, inhibited; autophagy, inhibited; cytoskeletal reorganization; translation, inhibited PPP2CA(INDUCES); PPP2R5B(INDUCES); HSP90A(NOT_REPORTED); CHIP(INDUCES) 10974038; 11375271; 11694516; 11818508; 11934884; 12032135; 12529330; 14522959; 14623889; 15082758; 17562705; 18570920; 18851840; 19061837; 19305428; 19325558; 20332342; 20530873; 21195350; 21329884; 21498666; 21550972; 21767636; 21775285; 21804606; 21847090; 21852229; 21956113; 21965330; 22388104; 22509246; 23359250; 24448243; 24498331; 24563481; 24614172; 25119572; 25143441; 26536663; 28600288; 31672472; 32116552; 32473126; 33048163; 33547375; 33664496; 33742122; 33786575; 33804171; 33836590; 33865855; 33869980; 34111424; 34118691; 34234346; 34298892; 34314419; 34343610; 34380537; 34473230; 34556581; 34608264; 34664403; 34694913; 34706731; 34710087; 34714866; 34910106; 34921114; 35210557; 35305679; 35358489; 35489019; 35641033; 35650206; 35896382; 35921893; 36012713; 36065437; 36192478; 36198369; 36263130; 36310322; 36473049; 36520801; 36870057; 36884349; 36997926; 37418003; 37439870; 37610873 1956 25 44 -Rhot1 RHOT1 EC 3.6.5.-; G protein; G protein, monomeric; G protein, monomeric, Rho; Hydrolase; Membrane protein, integral; Mitochondrial NP_001100496 303351 10q25-q26 rat K105-ac 11318024 NNKHSIDkVTSRWIP Ras cell growth, induced 31068376 1 1 0 increases mitochondrial transport and axon growth in DRG neurons -Mafa MAFA DNA-binding; Oncoprotein; Transcription factor; Tumor suppressor Q8CF90 378435 15|15 D3 mouse S14-p 1713900 MGAELPSsPLAIEYV molecular association, regulation MAFA(INDUCES) DNA(NOT_REPORTED) 20208071 2 2 0 -ERBB4 HER4 EC 2.7.10.1; KINASE; Kinase, protein; Membrane protein, integral; Protein kinase, TK; Protein kinase, tyrosine (receptor) Q15303 2066 2q34 human Y1258-p 451685 STLQHPDyLQEYSTK molecular association, regulation SHC1(INDUCES) 18721752 0 2 2 -Trpm8 TRPM8 Channel, cation; Membrane protein, integral; Membrane protein, multi-pass Q8R455 171384 9q35 rat Y1022-p 1877492902 FVVFAYFyMVVKKCF molecular association, regulation; ubiquitination; phosphorylation carcinogenesis, induced; cell motility, induced; cell growth, induced 14-3-3 zeta(INDUCES); TRPM8(INDUCES) 35665750 1 1 0 modulates LCK ubiquitination and phosphorylation -CLK2 CLK2 EC 2.7.12.1; KINASE; Kinase, protein; Protein kinase, CMGC; Protein kinase, dual-specificity (non-receptor) P49760 1196 1q22 human T127-p 15339202 RRRRRSRtFSRSSSQ apoptosis, altered; cell growth, altered 20682768 1 0 0 -IQCB1 IQCB1 Cell development/differentiation Q15051 9657 3q13.33|3q21.1 human K396-ub 95155304 KSALIIQkHWRGYRE IQ intracellular localization cell cycle regulation; cytoskeletal reorganization 28498859 1 1 0 regulation of cilia formation -MAP4 MAP4 Cytoskeletal; Motility/polarity/chemotaxis P27816 4134 3p21.31 human K847-ac 6216716 EGKPAEVkKMTAKSV cytoskeletal reorganization 28002468 1 2 3 -Kcnb1 Kv2.1 Channel, cation; Channel, ligand-gated; Channel, potassium; Membrane protein, integral; Membrane protein, multi-pass P15387 25736 3q42 rat Y690-p 22874701 LLPSLGLyHDPLRNR intracellular localization 22106938 2 2 2 regulates intracellular trafficking of Kv2.1 -Esrp2 RBM35B RNA-binding Q8K0G8 77411 8|8 D3 mouse K418-ub 52473101 RHKGMLGkRYIELFR carcinogenesis, inhibited; RNA splicing, induced; cell growth, inhibited 26522722 1 0 0 -RPL11 RPL11 Motility/polarity/chemotaxis; Nucleolus; Ribosomal; Translation P62913 6135 1p36.11 human K154-ne 12067607 RTGCIGAkHRISKEE Ribosomal_L5_C protein stabilization; intracellular localization 19713960 1 0 0 -PLEKHG1 PLEKHG1 GEF; GEF, Rac/Rho Q9ULL1 57480 6q25.1 human Y742-p 1876191900 QAVEENIyDTIGLPD activity, induced; molecular association, regulation; intracellular localization transcription, induced; cytoskeletal reorganization Fyn(INDUCES) 35031323 1 0 0 -SHC1 SHC1 iso2 Adaptor/scaffold; Apoptosis; Mitochondrial; Motility/polarity/chemotaxis P29353-2 6464 1q21.3 human Y448-p 33664400 SVSHLISyHMDNHLP SH2 molecular association, regulation JAK3(INDUCES) 24795043 1 0 0 -ATP2B2 ATP2B2 Cell development/differentiation; EC 3.6.3.8; Endoplasmic reticulum; Hydrolase; Membrane protein, integral; Membrane protein, multi-pass; Transporter; Transporter, ion channel Q01814 491 3p25.3 human T1139-p 11422300 RGLNRIQtQIRVVKA ATP_Ca_trans_C enzymatic activity, induced 1827443 1 0 0 effect (activation vs. inhibition) depends on PKC isozyme and lipid associated with ATP2B2 -Pacsin1 PACSIN1 Adaptor/scaffold Q61644 23969 17|17 A3.3 mouse T181-p 3827765 SKTEQSVtPEQQKKL molecular association, regulation; protein processing cytoskeletal reorganization; cell growth, altered 22355135 1 7 6 regulates lipid binding -NKAP NKAP Unknown function Q8N5F7 79576 Xq24 human S149-p 449164 APEVWGLsPKNPEPD NKAP intracellular localization transcription, induced; signaling pathway regulation 31461649 1 80 1 enhances NF-KB nuclear localization, regulates PTEN/NKAP/NF-KB/PDHK1 signaling -DSN1 DSN1 Cell cycle regulation Q9H410 79980 20q11.23 human S28-p 460419 HDHQLESsLSPVEVF intracellular localization 25660545 1 10 0 localization to G1 and G2 kinetochores -WWP2 WWP2 EC 6.3.2.-; EC 6.3.2.19; Ligase; UBIQUITIN LIGASE; Ubiquitin conjugating system; Ubiquitin ligase O00308 11060 16q22.1 human K473-sm 62489905 NTRTTTFkDPRPGFE WW molecular association, regulation PTEN(INDUCES) 27852060 1 0 0 -SCAMP3 SCAMP3 Membrane protein, integral; Membrane protein, multi-pass; Vesicle O14828 10067 1q22 human Y86-p 455165 EPKNYGSySTQASAA molecular association, regulation; phosphorylation cell cycle regulation; carcinogenesis, inhibited; cell growth, inhibited EGFR(INDUCES) 33850265 1 9 100 induces EGFR degradation, inhibits ERK phosphorylation -Aicda AID EC 3.5.4.38; Hydrolase Q9WVE0 11628 6|6 F1 mouse S38-p 457604 YVVKRRDsATSCSLD APOBEC2 molecular association, regulation; intracellular localization; enzymatic activity, induced DNA repair, induced; chromatin organization, altered; DNA repair, inhibited RPA1(INDUCES) DNA(INDUCES) 16251902; 16723391; 17911613; 18951095; 21113164; 36603026 12 3 0 -Rbbp8 CtIP EC 3.1.-.-; Transcription, coactivator/corepressor Q80YR6 225182 18|18 A1 mouse T855-p 27427901 WEVGFPStQTCLERG SAE2 phosphorylation cell cycle regulation; carcinogenesis, induced; DNA repair, induced; cell growth, inhibited; cell growth, induced; transcription, inhibited; signaling pathway regulation 31097467; 32989150; 34521752; 36640339 6 1 0 -KDR VEGFR2 EC 2.7.10.1; KINASE; Kinase, protein; Membrane protein, integral; Protein kinase, TK; Protein kinase, tyrosine (receptor) P35968 3791 4q12 human S229-p 56790201 RIYDVVLsPSHGIEL Ig_3 receptor internalization, inhibited cell motility, induced; cell adhesion, altered 27438154 1 0 0 mediates cell invasion and migration -ARHGEF7 ARHGEF7 GEF; GEF, Rac/Rho; Motility/polarity/chemotaxis Q14155 8874 13q34 human S761-p 14569926 DSLGRRSsLSRLEPS exocytosis, induced 25009260 1 2 0 dopamine release -Polr2a POLR2A EC 2.7.7.48; EC 2.7.7.6; Nucleotide Metabolism - purine; Nucleotide Metabolism - pyrimidine; Transcription initiation complex; Transferase P08775 20020 11 B3|11 42.86 cM mouse K1866-ub 2134724 KYSPTSPkYSPTSPK RNA_pol_Rpb1_R protein degradation 17526739 1 1 0 -Bad BAD Apoptosis O35147 64639 1q43 rat S112-p 5209400 METRSRHsSYPAGTE Bcl-2_BAD apoptosis, inhibited 33603838 2 9 71 increased cell viability -Aqp2 AQP2 Channel, misc.; Membrane protein, integral; Membrane protein, multi-pass; Transporter; Transporter, aquaporin family P34080 25386 7q36 rat S264-p 2238600 VELHSPQsLPRGSKA ubiquitination; intracellular localization; activity, inhibited exocytosis, induced; endocytosis, inhibited 18287043; 26147297; 27488997; 32113684 20 8 0 -MYCN N-Myc DNA-binding; Oncoprotein; Transcription factor P04198 4613 2p24.3 human R65-me 59175205 TPPLSPSrGFAEHSS Myc_N protein stabilization 27571165 1 0 0 -CALM1 Calmodulin Calcium-binding; Protein phosphatase, regulatory subunit P0DP23 801 14q32.11 human T118-p 469586 TNLGEKLtDEEVDEM EF-hand_7 protein conformation 26675311 4 1 0 -Aqp2 AQP2 Channel, misc.; Membrane protein, integral; Membrane protein, multi-pass; Transporter; Transporter, aquaporin family P34080 25386 7q36 rat K270-ub 999601 QSLPRGSkA______ intracellular localization 21148409 6 0 0 -Gsk3b GSK3B EC 2.7.11.1; EC 2.7.11.26; KINASE; Kinase, protein; Protein kinase, CMGC; Protein kinase, Ser/Thr (non-receptor) P18266 84027 11q21 rat Y216-p 448569 RGEPNVSyICSRYYR Pkinase enzymatic activity, induced apoptosis, induced 10995469; 36371197; 8382613 98 128 4206 -ACE2 ACE2 EC 3.4.17.23; Membrane protein, integral; Protease Q9BYF1 59272 Xp22.2 human K31-me 1881568100 QAKTFLDkFNHEAED Peptidase_M2 molecular association, regulation Spike Glycoprotein(DISRUPTS) 34031383 1 0 0 ACE2 peptide inhibitors, inhibit spike complexes at the cell surface, signi?cantly reduced SARS-CoV-2 spike protein at the cell surface and intracellularly in infected cells -FKBP5 FKBP5 Chaperone; EC 5.2.1.8; Isomerase Q13451 2289 6p21.31 human Y54-p 456461 PMIGDKVyVHYKGKL FKBP_C protein degradation; molecular association, regulation; ubiquitination; activity, inhibited carcinogenesis, induced; autophagy, inhibited; signaling pathway regulation PHLPP(DISRUPTS) 34077419 1 3 11 induces AKT phosphorylation, regulates FKBP51-AKT-Beclin 1 pathway -BARD1 BARD1 EC 6.3.2.-; EC 6.3.2.19; Ligase; UBIQUITIN LIGASE; Ubiquitin conjugating system; Ubiquitin ligase Q99728 580 2q35 human T714-p 465470 PKPDSDVtQTINTVA RNA stability, altered 16651405 1 0 1 inhibits mRNA processing -DNER DNER Membrane protein, integral; Receptor, misc. Q8NFT8 92737 2q36.3 human Y681-p 473322 RPAYEEFyNCRSIDS DNER_C intracellular localization 18474614 1 0 2 -Rac1 RAC1 G protein; G protein, monomeric; G protein, monomeric, Rho; Motility/polarity/chemotaxis P63001 19353 5 G2|5 82.22 cM mouse K147-ub 2142500 PQGLAMAkEIGAVKY Ras protein degradation cell motility, inhibited 22117219 3 12 26 regulates epithelial?mesenchymal transition (EMT) -CAMK4 CAMK4 EC 2.7.11.17; KINASE; Kinase, protein; Protein kinase, CAMK; Protein kinase, Ser/Thr (non-receptor) Q16566 814 5q22.1 human T57-gl 7780007 SELGRGAtSIVYRCK Pkinase phosphorylation 19506079 1 1 0 reduce phosphorylation at CAMK4-T200 -Pak3 PAK3 EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, STE; Protein kinase, Ser/Thr (non-receptor) Q62829 29433 Xq33 rat S139-p 448123 VNNQKYMsFTSGDKS enzymatic activity, induced 11278486 5 5 0 -BCL2 Bcl-2 Apoptosis; Autophagy; Membrane protein, integral; Oncoprotein P10415 596 18q21.33 human T56-p 448655 FSSQPGHtPHPAASR molecular association, regulation; protein stabilization; ubiquitination cell cycle regulation; apoptosis, altered; apoptosis, induced; apoptosis, inhibited PPP1CA(INDUCES); CDK1(INDUCES); NCL(INDUCES) 10669763; 10766756; 11077443; 11495898; 12039864; 15876860; 16714293; 18794113; 19336399 12 1 0 phosphorylation induced by viral infection -MAST1 MAST1 EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, AGC; Protein kinase, Ser/Thr (non-receptor) Q9Y2H9 22983 19p13.13 human K545-ub 573791192 DAREFLDkQVCGTPE Pkinase protein degradation 31449053 1 2 0 proteasomal degradation sensitizes cisplatin-resistant cells to cisplatin -Marcksl1 MLP Cell cycle regulation P28667 17357 4 D2.2|4 63.26 cM mouse S104-p 465848 PFKLSGLsFKRNRKE MARCKS intracellular localization cytoskeletal reorganization 21602810 1 74 60 -Scnn1g ENaC-gamma Channel, sodium; Membrane protein, integral; Membrane protein, multi-pass; Transporter, ion channel P37091 24768 1q36 rat T599-p 2228601 QDNPALDtDDDLPTF activity, induced; intracellular localization 18308722 1 0 0 membrane expression of ENAC beta and gamma, and may translocate CK2 to the cell membrane.; channel activation -VDAC1 VDAC1 Channel, misc.; Membrane protein, integral; Mitochondrial P21796 7416 5q31.1 human S104-p 452268 LTFDSSFsPNTGKKN Porin_3; TM protein stabilization apoptosis, induced 18381814 2 84 0 -SMAD2 SMAD2 DNA-binding; Transcription factor Q15796 4087 18q21.1 human S464-p 447567 GSPSVRCsSMS____ activity, induced; intracellular localization transcription, induced; transcription, altered SMAD4(INDUCES) 11043574; 8980228 5 1 1 -NBN NBS1 Cell cycle regulation; DNA repair, damage O60934 4683 8q21.3 human S432-p 483547 RIPNYQLsPTKLPSI molecular association, regulation; intracellular localization cell cycle regulation; chromatin organization, altered; DNA repair, altered; apoptosis, inhibited TRF2(DISRUPTS) 22927831; 28216226 4 40 0 radioprotective effects; recruitment of Apollo/SNM1B to leading strand telomeres, regulates telomere repair choice -Mcm2 MCM2 DNA-binding; EC 3.6.4.12 P97310 17216 6|6 D1 mouse S40-p 452311 RRADALTsSPGRDLP cell cycle regulation; DNA repair, inhibited 31488723; 35508654 12 29 18 -ACTL6A BAF53A O96019 86 3q26.33 human S86-p 18908932 RENMEAIsPLKNGMV Actin molecular association, regulation apoptosis, induced; transcription, induced RASSF6(INDUCES) 34898277 1 7 1 -MIEN1 MIEN1 Apoptosis; Motility/polarity/chemotaxis Q9BRT3 84299 17q12 human Y50-p 48921820 ASAVKEQyPGIEIES Rdx carcinogenesis, induced; cell motility, induced 26272794 1 0 0 -Spag5 SPAG5 Cell cycle regulation Q7TME2 54141 11 B5|11 46.74 cM mouse S66-p 460412 KERCNNSsPVDFINT cell cycle regulation 19806032 1 9 1 T24/66/447A mutant impairs meiosis progression -SUGT1 SUGT1 Cell cycle regulation; Ubiquitin conjugating system Q9Y2Z0 10910 13q14.3 human S331-p 18016406 VKRAMNKsFMESGGT SGS molecular association, regulation; intracellular localization cell cycle regulation; cytoskeletal reorganization HSP90A(INDUCES); DSN1(INDUCES) 21864708; 22869522 2 6 2 localization at kinetetchore; mitotic progression; association with MIS12 complex; kinetochore-microtubule attachments -Syn3 SYN3 Vesicle O70441 29130 7q13 rat S404-p 482763 VPGASVPsPLRPWGP cell motility, induced 25843720 1 5 0 neuronal migration and orientation -KAT5 Tip60 ACETYLTRANSFERASE; Acetyltransferase; EC 2.3.1.48; Nuclear receptor co-regulator; Nucleolus Q92993 10524 11q13.1 human S199-p 4759900 CLGTDEDsQDSSDGI protein stabilization; acetylation; enzymatic activity, induced 36280132 1 16 13 induces autoacetylation, delays degradation -WASF3 WASF3 Actin-binding; Motility/polarity/chemotaxis Q9UPY6 10810 13q12.13 human Y248-p 486449 HASDVTDySYPATPN cell motility, induced; cytoskeletal reorganization 17623672 1 1 1 induces lamellipodia formation -GATA3 GATA3 Transcription factor P23771 2625 10p14 human K304-ac 460635 NRPLIKPkRRLSAAR intracellular localization cell growth, inhibited; transcription, induced 10970860 1 0 0 regulated survival after activation, regulates T-cell trafficking to secondary -RUVBL1 RUVBL1 EC 3.6.4.12; Helicase; Motility/polarity/chemotaxis Q9Y265 8607 3q21.3 human R205-m2 63128908 GAVKRQGrCDTYATE TIP49 DNA repair, induced 28238654 1 1 0 -MAVS MAVS Adaptor/scaffold; Membrane protein, integral Q7Z434 57506 20p13 human K362-ub 12302372 RAGMVPSkVPTSMVL protein degradation 20483786; 31270229 2 1 1 -FLRT1 FLRT1 Cell adhesion; Membrane protein, integral; Motility/polarity/chemotaxis Q9NZU1 23769 11q13.1 human Y633-p 14150100 PYRAKEEyVVHTIFP intracellular localization cell growth, altered 20421966 1 0 0 regulates ERK1/2 activation -EGFR EGFR EC 2.7.10.1; KINASE; Kinase, protein; Membrane protein, integral; Oncoprotein; Protein kinase, TK; Protein kinase, tyrosine (receptor) P00533 1956 7p11.2 human S695-p 451484 LVEPLTPsGEAPNQA receptor internalization, altered carcinogenesis, induced; cell motility, induced 2115882; 35000271; 7505275 5 11 3 -Ppara PPAR-alpha DNA-binding; Nuclear receptor; UBIQUITIN LIGASE P23204 19013 15 E2|15 40.42 cM mouse S73-p 59026900 SVITDTLsPASSPSS protein degradation; ubiquitination; activity, inhibited transcription, inhibited 27738106; 28096081 2 0 0 -Neurog1 neurogenin 1 Cell development/differentiation; DNA-binding; Transcription factor P70660 18014 13 B1|13 30.06 cM mouse T130-p 1186000 FPDDTKLtKIETLRF HLH protein stabilization; molecular association, regulation E2A(NOT_REPORTED) 17623011 1 0 0 frog (Xenopus) E2A -NSF NSF Adaptor/scaffold; Autophagy; EC 3.6.4.6; Protease; Vesicle P46459 4905 17q21.31 human Y83-p 453414 QEIEVSLyTFDKAKQ CDC48_N molecular association, regulation; enzymatic activity, inhibited; enzymatic activity, induced exocytosis, inhibited SNAP-alpha(DISRUPTS); PTP1B(INDUCES) 15322554; 31194868 2 1 0 -Adrb2 ADRB2 GPCR, family 1; Membrane protein, integral; Membrane protein, multi-pass; Receptor, GPCR P04274 101836719 hamster S261-p 447908 SGHGLRRsSKFCLKE 7tm_1 receptor desensitization, altered 8083204 9 2 0 S262 was primary site of cAPK desensitization, while either 261 or 262 for PKC desensitization, as well as ADRB2 expression level. -CCDC88A girdin Actin-binding Q3V6T2 55704 2p16.1 human Y1765-p 450761 PRKTEDTyFISSAGK molecular association, regulation; phosphorylation carcinogenesis, induced; exocytosis, induced; cell motility, induced; cytoskeletal reorganization; signaling pathway regulation PIK3R1(INDUCES) 21954290; 26887938; 36822326 4 14 36 induces Nephrin and AKT phosphorylation, induces PI3K/Akt signaling -TCF3 E2A Cell development/differentiation; DNA-binding; Oncoprotein; Transcription factor P15923 6929 19p13.3 human S341-p 10359100 KALASIYsPDHSSNN activity, inhibited transcription, inhibited 19801649 1 1 4 -EDNRA EDNRA GPCR, family 1; Membrane protein, integral; Membrane protein, multi-pass; Motility/polarity/chemotaxis; Receptor, GPCR P25101 1909 4q31.22-q31.23 human S421-p 2911708 NHNTDRSsHKDSMN_ receptor desensitization, induced 24064210 1 1 0 Lack of S397, T403 and S404 influences desensitization to a greater extent compared than S391, S393, and T396 -SH3RF1 SH3RF1 Adaptor/scaffold; EC 6.3.2.-; EC 6.3.2.19; Ligase; UBIQUITIN LIGASE; Ubiquitin conjugating system; Ubiquitin ligase Q7Z6J0 57630 4q32.3-q33 human S304-p 482847 KNTKKRHsFTSLTMA molecular association, regulation apoptosis, inhibited RAC1(INDUCES) 17535800 2 18 22 -Foxo6 FOXO6 DNA-binding Q70KY4 329934 4|4 D2.1 mouse T26-p 2899101 QSRPRSCtWPLPQPD intracellular localization transcription, inhibited 12857750; 15987244 2 0 0 Mediates growth factor sensitivity and inhibition transcriptional activity independent of translocation. ; nuclear export -FFAR4 GPR120 iso1 GPCR, family 1; Lipid-binding; Membrane protein, integral; Membrane protein, multi-pass; Receptor, GPCR Q5NUL3-1 338557 10q23.33 human T363-p 31014807 PEKGAILtDTSVKRN receptor internalization, induced; molecular association, regulation ARR3(INDUCES); ARRB1(INDUCES) 24412271; 24817122 5 1 0 -COPS6 COPS6 Cell cycle regulation Q7L5N1 10980 7q22.1 human S148-p 48903200 QVCEIIEsPLFLKLN JAB protein stabilization carcinogenesis, induced; cell motility, induced; cell growth, induced 26267535 1 0 0 -OPRL1 KOR-3 GPCR, family 1; Membrane protein, integral; Membrane protein, multi-pass; Receptor, GPCR P41146 4987 20q13.33 human T362-p 1868135702 DVALACKtSETVPRP receptor internalization, induced; receptor desensitization, induced signaling pathway regulation 30914485 2 0 0 -SMAD5 SMAD5 DNA-binding; Transcription, coactivator/corepressor Q99717 4090 5q31.1 human S465-p 448456 LNPISSVs_______ cell growth, inhibited; transcription, induced 35573984 7 18 41 -MAPK14 P38A EC 2.7.11.24; KINASE; Kinase, protein; Protein kinase, CMGC; Protein kinase, Ser/Thr (non-receptor) Q16539 1432 6p21.31 human K152-ac 18575505 DIIHRDLkPSNLAVN Pkinase molecular association, regulation; phosphorylation; enzymatic activity, induced apoptosis, induced Other(INDUCES) 21444723 1 1 0 induces ATP binding, induces phosphorylation of ATF2 -CDT1 CDT1 DNA replication; DNA-binding; Motility/polarity/chemotaxis; Oncoprotein Q9H211 81620 16q24.3 human T7-p 1239966005 _MEQRRVtDFFARRR cell cycle regulation; cytoskeletal reorganization 30154187 1 1 0 regulates kTM stability -VIM Vimentin Cytoskeletal; Motility/polarity/chemotaxis P08670 7431 10p13 human S7-p 455449 _MSTRSVsSSSYRRM Filament_head cell motility, altered 19291697 8 21 1 -TP53 p53 Activator; DNA-binding; Motility/polarity/chemotaxis; Nuclear receptor co-regulator; Transcription factor; Tumor suppressor P04637 7157 17p13.1 human S215-p 454242 DRNTFRHsVVVPYEP P53 protein degradation; molecular association, regulation; protein stabilization; ubiquitination; protein conformation; activity, inhibited cell cycle regulation; carcinogenesis, induced; cell motility, inhibited; transcription, induced; transcription, altered; apoptosis, inhibited; transcription, inhibited; cell growth, altered DNA(DISRUPTS) 15469940; 20847049; 22611192; 25691063; 27496712 6 0 0 -IRF7 IRF7 DNA-binding; Transcription factor Q92985 3665 11p15.5 human S483-p 486437 SSLSLCLsSANSLYD transcription, inhibited 10893229 3 0 0 -TNS3 tensin 3 Adaptor/scaffold; Motility/polarity/chemotaxis Q68CZ2 64759 7p12.3 human Y1256-p 462739 KGCSNEPyFGSLTAL SH2 molecular association, regulation cell motility, altered; cell growth, altered P130Cas(INDUCES); KHDRBS1(INDUCES); FAK(INDUCES) 19732724 1 1 17 contributes to tumorigenesis and metastasis -Camk2b CAMK2B EC 2.7.11.17; KINASE; Kinase, protein; Protein kinase, CAMK; Protein kinase, Ser/Thr (non-receptor) P28652 12323 11 A1|11 3.89 cM mouse T287-p 450048 SMMHRQEtVECLKKF phosphorylation; enzymatic activity, induced cell cycle regulation; cell growth, induced; signaling pathway regulation 15944130; 19004831; 33755308; 34088288 32 17 109 CaMKII/c-Myc/CDK6 pathway; induces phosphorylation of RYR2 further modulating cardiac function -CRYAB CRYAB Chaperone; Heat shock protein P02511 1410 11q23.1 human S45-p 448748 FPTSTSLsPFYLRPP Crystallin activity, induced; protein degradation; molecular association, regulation; intracellular localization; activity, inhibited; protein conformation exocytosis, inhibited; apoptosis, inhibited FBXO4(INDUCES); CASP7(INDUCES); CRYAB(DISRUPTS); CASP3(INDUCES); GEMIN3(INDUCES); CASP2(DISRUPTS) 11096101; 12468532; 15117944; 15511225; 16129694; 16928191; 18061612; 23049853; 24023879; 26620801; 27641668 35 7 1 -PFKFB2 PFKFB2 Carbohydrate Metabolism - fructose and mannose; EC 2.7.1.105; EC 3.1.3.46; Kinase, other; Motility/polarity/chemotaxis; Phosphatase (non-protein) P26285 287019 cow S467-p 448460 PVRMRRNsFTPLSSS molecular association, regulation; enzymatic activity, induced Other(INDUCES) 2846551; 9211863 10 60 333 -EEF2 EEF2 Translation; Translation elongation P55823 rabbit T58-p 450254 GETRFTDtRKDEQER GTP_EFTU activity, inhibited 8386634 5 30 31 -YWHAZ 14-3-3 zeta Adaptor/scaffold; Motility/polarity/chemotaxis P63104 7534 8q22.3 human S184-p 449855 FYYEILNsPEKACSL 14-3-3 protein stabilization; molecular association, regulation; protein conformation; phosphorylation HSP20(INDUCES); JNK1(NOT_REPORTED); BAX(DISRUPTS) 15071501; 16009721; 18559254; 21081103 7 4 0 -Gabbr2 GABBR2 GPCR, family 3; Membrane protein, integral; Membrane protein, multi-pass; Receptor, GPCR O88871 83633 5q22 rat S783-p 473060 VTSVNQAsTSRLEGL GBR2_CC activity, induced; intracellular localization signaling pathway regulation 17224405; 20643948; 27498877 10 0 0 regulates postendocytic sorting of GABA receptors; decreases attenuation of receptor activation; accumulating GABBR2 at presynaptic terminals; promotes neuronal survival after ischemia -DDX39A DDX39 EC 3.6.4.13; Helicase; RNA splicing; RNA-binding O00148 10212 19p13.12 human K52-sm 1876998412 GFRDFLLkPELLRAI molecular association, regulation RNA(DISRUPTS) 32393512 1 1 0 -FGFBP1 FGFBP1 Q9MZ06 281812 cow S36-p 487543 NRRGSKAsADESLAL FGF-BP1 molecular association, regulation FGF1(DISRUPTS) 17560725 1 0 0 -DSN1 DSN1 Cell cycle regulation Q9H410 79980 20q11.23 human S100-p 480153 RQSWRRAsMKETNRR MIS13 molecular association, regulation; intracellular localization MIS12(INDUCES); CENPC1(INDUCES) 18640974; 25601404; 25660545; 27881301; 34758321 7 4 5 -NCL NCL DNA-binding; Helicase; Nuclear receptor co-regulator; Nucleolus; RNA-binding P19338 4691 2q37.1 human T707-p 21697921 HKPQGKKtKFE____ molecular association, regulation; protein stabilization carcinogenesis, induced; cell growth, induced; RNA stability, induced; translation, induced RNA(INDUCES) 21998300; 25173817 2 0 0 induces binding to Sp1 RNA and IRES-mediated Sp1 expression -Kcna2 Kv1.2 Channel, potassium; Membrane protein, integral; Membrane protein, multi-pass P63142 25468 2q34 rat S440-p 1818100 TSCPKIPsSPDLKKS intracellular localization 18056633 1 7 0 -PARK7 DJ-1 EC 3.4.-.-; Nuclear receptor co-regulator; Transcription regulation; Tumor suppressor Q99497 11315 1p36.23 human K130-sm 2407414 VTTHPLAkDKMMNGG DJ-1_PfpI molecular association, regulation; intracellular localization cell growth, induced; apoptosis, induced; apoptosis, inhibited; transcription, inhibited PIAS1(DISRUPTS) 11477070; 15976810; 18339323 4 0 0 -Ppargc1b PGC-1 beta Nuclear receptor co-regulator; Transcription, coactivator/corepressor Q8VHJ7 170826 18|18 E1 mouse K645-ac 7761206 ATPGASHkLPKRHPE intracellular localization transcription, inhibited 19491097 1 1 0 -FER Fer EC 2.7.10.2; KINASE; Kinase, protein; Oncoprotein; Protein kinase, TK; Protein kinase, tyrosine (non-receptor) P16591 2241 5q21.3 human Y714-p 448461 RQEDGGVySSSGLKQ PK_Tyr_Ser-Thr enzymatic activity, induced 19159681 3 34 611 -KIR3DL1 KIR3DL1 Membrane protein, integral; Receptor, misc. P43629 3811 19q13.42 human S388-p 990303 RTANSEDsDEQDPEE activity, induced; receptor internalization, altered 17911614 1 0 0 -PPP6R2 SAPS2 Unknown function O75170 9701 22q13.33 human S771-p 4764365 ESGPRCSsPVDTECS molecular association, regulation cell cycle regulation PLK1(INDUCES) 29764989 1 14 1 -UBA1 UBE1 EC 6.3.2.19; UBIQUITIN LIGASE; Ubiquitin conjugating system; Ubiquitin ligase P22314 7317 Xp11.3 human K604-ub 3934846 ESGTLGTkGNVQVVI ThiF enzymatic activity, induced 33355669 1 7 31 inhibition of viral DNA replication and virus production -RRAS RRas G protein; G protein, monomeric; G protein, monomeric, Ras; Motility/polarity/chemotaxis P10301 6237 19q13.33 human S201-p 18015221 QEQELPPsPPSAPRK activity, induced 27086924 1 7 0 -PRKCE PKCE EC 2.7.11.13; KINASE; Kinase, protein; Protein kinase, AGC; Protein kinase, Ser/Thr (non-receptor) Q02156 5581 2p21 human S350-p 486055 RSKSAPTsPCDQEIK molecular association, regulation; intracellular localization; phosphorylation cell cycle regulation 14-3-3 zeta(DISRUPTS) 18604201; 34143863 2 10 0 C1A and C1B domains are necessary for localization, and inter-C1 domain (IC1D) domains for retention at the midbody, S350 dephosphorylation is necessary for 14-3-3 complex assembly, and for Aurora B S227 phosphorylation at the midbody -ARHGAP35 GRF-1 GAP; GAP, Rac/Rho; Motility/polarity/chemotaxis; Transcription factor; Tumor suppressor Q9NRY4 2909 19q13.32 human Y1105-p 448941 RNEEENIySVPHDST RhoGAP_pG1_pG2 activity, induced; molecular association, regulation cell motility, induced RASA1(INDUCES) 16513268; 30664792; 32540970 5 83 3224 -IKBKB IKKB EC 2.7.11.10; KINASE; Kinase, protein; Protein kinase, Other; Protein kinase, Ser/Thr (non-receptor) O14920 3551 8p11.21 human S181-p 447489 DQGSLCTsFVGTLQY Pkinase activity, induced; molecular association, regulation; protein stabilization; ubiquitination; intracellular localization; phosphorylation; enzymatic activity, induced carcinogenesis, induced; cell growth, induced; cell motility, altered; transcription, induced; transcription, inhibited; transcription, altered; signaling pathway regulation IKKA(INDUCES) 10195894; 11325957; 11460167; 16267042; 17150968; 18930133; 18950704; 19073147; 24833394; 35173553; 35339487; 35476515; 35525271; 9346484 76 2 0 NFkB pathway; induces IKB phosphorylation; regulates NFkB signaling; induces induces nuclear localization of p65, thus inducing the TNFa/NF-kB signaling pathway -RB1 Rb Nuclear receptor co-regulator; Oncoprotein; Transcription, coactivator/corepressor; Tumor suppressor P06400 5925 13q14.2 human K720-sm 3817003 KVKNIDLkFKIIVTA RB_B protein stabilization; molecular association, regulation cell growth, induced; transcription, inhibited lamin A/C(INDUCES) 15806172; 27270425 2 0 0 -FLI1 FLI1 DNA-binding; Oncoprotein; Transcription factor Q01543 2313 11q24.3 human K380-ac 6406003 PTESSMYkYPSDISY protein degradation; molecular association, regulation transcription, induced DNA(DISRUPTS) 17884818; 22973553; 24058639 3 1 0 -KLF10 KLF10 C2H2-type zinc finger protein; DNA-binding; Transcription factor Q13118 7071 8q22.3 human T445-p 20573500 FMRSDHLtKHARRHL zf-C2H2 intracellular localization transcription, induced 20953893 1 0 0 -PRKAA1 AMPKA1 Autophagy; EC 2.7.11.1; EC 2.7.11.26; EC 2.7.11.27; EC 2.7.11.31; KINASE; Kinase, protein; Protein kinase, CAMK; Protein kinase, Ser/Thr (non-receptor) Q13131 5562 5p13.1 human K71-ub 964497636 RSLDVVGkIRREIQN Pkinase enzymatic activity, inhibited 31996460 1 1 0 -HDAC6 HDAC6 DEACETYLASE; Deacetylase; EC 3.5.1.98; Nuclear receptor co-regulator; Ubiquitin conjugating system Q9UBN7 10013 Xp11.23 human S458-p 18944908 EEDNVEEsEEEGPWE molecular association, regulation; intracellular localization autophagy, induced; chromatin organization, altered; apoptosis, inhibited; cytoskeletal reorganization DNAH1(INDUCES) 21486957 1 1 0 chromatin condensation, induces tubulin deacetylation and increase aggresomes -SIRPA SHPS1 Cell adhesion; Cell surface; Membrane protein, integral; Motility/polarity/chemotaxis; Receptor, misc. P78324 140885 20p13 human Y496-p 451115 PEPSFSEyASVQVPR molecular association, regulation; phosphorylation cell motility, induced; cell growth, induced; signaling pathway regulation CTK(INDUCES); SHP-2(INDUCES); SHP-1(INDUCES) 10842184; 18233962; 21799000 5 16 136 regulation TLR3/4-dependent cytokine production pathway; Mutation of these 4 tyrosines does not affect JAK2 binding. However, overexpression of the WT SHPS1 but not the 4 tyrosine to phenylalanine mutation reduces tyrosine phosphorylation of Jak2, STAT5B, and STAT3 and activation of Erk1/2 in response to growth hormone. Does not affect STAT3 tyrosine phosphorylation in response to LIF agonist.; induces phosphorylation of itself at Y429 and Y453, and of MAPK, regulates SHPS1- signaling -EIF6 EIF6 Nucleolus; Translation; Translation initiation P56537 3692 20q11.22 human S239-p 3193264 IATSMRDsLIDSLT_ intracellular localization translation, altered 32703900 1 10 0 -Sh3pxd2a Tks5 Adaptor/scaffold O89032 14218 19|19 C3 mouse Y557-p 458193 VKYEEPEyDVPAFGF molecular association, regulation cell cycle regulation; cell motility, altered; cytoskeletal reorganization NCK1(INDUCES); NCK2(INDUCES); WASP(INDUCES) 18515860; 19596797 1 4 11 -NPM/ALK NPM-ALK KINASE; Kinase, protein; Protein kinase, TK; Protein kinase, tyrosine (receptor) AAA58698 human Y343-p 27275115 DIYRASYyRKGGCAM PK_Tyr_Ser-Thr molecular association, regulation; enzymatic activity, induced carcinogenesis, altered VAV3(INDUCES); SHP-1(INDUCES) 17998938; 19887368; 20424160 4 2 3 SHP1 phosphatase mediates tyrosine dephosphorylation of ALK -MAPK3 ERK1 EC 2.7.11.24; KINASE; Kinase, protein; Protein kinase, CMGC; Protein kinase, Ser/Thr (non-receptor) P27361 5595 16p11.2 human Y204-p 447543 HTGFLTEyVATRWYR Pkinase activity, induced; protein degradation; molecular association, regulation; intracellular localization; protein conformation; phosphorylation; enzymatic activity, induced cell cycle regulation; carcinogenesis, induced; apoptosis, altered; apoptosis, induced; cell motility, induced; cell motility, inhibited; signaling pathway regulation; cell growth, induced; cell motility, altered; transcription, inhibited; cell growth, altered; cell differentiation, inhibited; carcinogenesis, inhibited; cell growth, inhibited; transcription, induced; transcription, altered; autophagy, induced; cell differentiation, induced; apoptosis, inhibited; autophagy, inhibited; cytoskeletal reorganization TACE(INDUCES); ERK2(INDUCES); leupaxin(NOT_REPORTED); GSK3B(INDUCES); KSR(INDUCES) 10597231; 10925301; 11352917; 12368275; 12609989; 12808105; 12917346; 12952943; 15004239; 15059947; 16149052; 16397900; 16585161; 17562849; 17667937; 17685427; 18042541; 18045996; 18519681; 18658095; 18775330; 19088846; 19106095; 19144315; 20122898; 20228268; 20231899; 20868520; 21478863; 21530327; 21561860; 21685939; 21726627; 21730054; 21893193; 21917714; 21980390; 22385658; 23644655; 24632852; 25538243; 26073130; 26079947; 26586479; 27323830; 28574827; 30987999; 31722981; 31736979; 31933886; 32081857; 32107290; 33627405; 33667549; 33731431; 33820494; 33828192; 34017102; 34209868; 34226680; 34262144; 34380633; 34473994; 34480897; 34497368; 34588619; 34611296; 34611309; 34642304; 34675408; 34921013; 34992144; 35173310; 35293964; 35367211; 35414784; 35439648; 35544764; 36053753; 36216931; 36289618; 36346366; 36455198; 36509141; 36529291; 36966223; 37016335; 7535768; 8444886; 9124279 1366 142 3549 -MUTYH MUTYH DNA repair, damage; EC 3.2.2.-; Hydrolase; Mitochondrial; Tumor suppressor Q9UIF7 4595 1p34.1 human S535-p 15343401 NFFRSHIsTDAHSLN protein stabilization; enzymatic activity, induced 20724227 1 1 0 -Lime1 LIME1 Adaptor/scaffold; Membrane protein, integral Q9EQR5 72699 2|2 H4 mouse Y137-p 463651 STSSEATySNVGLAA LIME1 activity, induced GRB2(INDUCES) 16249387 2 0 2 -Trim28 TIF1B EC 6.3.2.-; KINASE; Kinase, protein; Ligase; Nuclear receptor co-regulator; Protein kinase, atypical; SUMO LIGASE; SUMO ligase; Transcription, coactivator/corepressor; UBIQUITIN LIGASE; Ubiquitin conjugating system; Ubiquitin ligase Q62318 21849 7|7 A1 mouse S824-p 460839 LPSAGLSsQELSGPG intracellular localization DNA repair, induced 22205726 47 9 6 -NOXO1 NOXO1 iso3 Adaptor/scaffold Q8NFA2-3 124056 16p13.3 human S154-p 27454492 SRAAGRLsIHSLEAQ molecular association, regulation; intracellular localization; protein conformation; enzymatic activity, induced GRB2(INDUCES); CYBA(INDUCES); NOXA1(INDUCES) 23322165; 26781991 3 4 0 EGF-dependent membrane translocation of NoxO1; required for optimal ROS production by NOX1 -NFKBIA IkB-alpha DNA-binding; Inhibitor P25963 4792 14q13.2 human K67-ub 15390764 PRGSEPWkQQLTEDG activity, induced; protein degradation 36229750 1 2 4 induced foam cell formation, pyroptosis, and in?ammation -Pnpla2 PNPLA2 EC 3.1.1.3; Lipase; Membrane protein, integral Q8BJ56 66853 7|7 F5 mouse T372-p 33673902 IRWMKEQtGSICQYL intracellular localization; enzymatic activity, inhibited 24801391 2 1 0 -ERBB2 HER2 EC 2.7.10.1; KINASE; Kinase, protein; Membrane protein, integral; Oncoprotein; Protein kinase, TK; Protein kinase, tyrosine (receptor) P04626 2064 17q12 human Y1196-p 448676 GAVENPEyLTPQGGA molecular association, regulation; phosphorylation; enzymatic activity, induced cell motility, altered; transcription, induced; signaling pathway regulation SHC1(INDUCES); CRK(INDUCES); SH3BGRL3(INDUCES); PAK1(INDUCES) 11238891; 16729043; 18332126; 19525980; 28842430 14 3 5 SLK activation, cell motility, leadiing to cancer cell invasion -Phlpp2 PHLPP2 EC 3.1.3.16; PHOSPHATASE; Protein phosphatase, Ser/Thr (non-receptor); Tumor suppressor Q8BXA7 244650 8|8 D3 mouse S1207-p 4754865 FGIRRQNsVNSGILL protein degradation; molecular association, regulation KCTD17(INDUCES) 28859855 1 22 6 -GAB1 GAB1 Adaptor/scaffold; Motility/polarity/chemotaxis Q13480 2549 4q31.21 human T387-p 4783368 MSPSRSNtISTVDLN cytoskeletal reorganization 22751113 1 6 0 -FOXO4 FOXO4 DNA-binding; Oncoprotein; Transcription factor P98177 4303 Xq13.1 human T227-p 15798100 PAPPEGAtPTSPVGH carcinogenesis, altered; transcription, altered 20959475 1 3 0 -CTBP1 CTBP1 Cell cycle regulation; EC 1.1.1.-; Nuclear receptor co-regulator; Oxidoreductase; Transcription, coactivator/corepressor Q13363 1487 4p16.3 human S158-p 455351 REGTRVQsVEQIREV 2-Hacid_dh; 2-Hacid_dh_C protein degradation; molecular association, regulation; ubiquitination; intracellular localization; enzymatic activity, inhibited transcription, induced; transcription, altered STF-1(DISRUPTS) 12872159; 18184656; 23291169 7 2 0 attenuates the repressive function of CtBP1 on Bax promoter -SMAD4 SMAD4 DNA-binding; Nuclear receptor co-regulator; Transcription, coactivator/corepressor Q13485 4089 18q21.2 human K159-sm 2793925 APSSMMVkDEYVHDF molecular association, regulation; protein stabilization; intracellular localization transcription, induced; transcription, inhibited; signaling pathway regulation DAXX(INDUCES) 12621041; 12740389; 14514699; 14750902; 15028714; 15637079 8 1 0 binding to DAXX induces DAXX recruitment to SMAD4 targeted promoter, further regulating TGF-beta signaling -ESR1 ER-alpha DNA-binding; Nuclear receptor; Transcription factor P03372 2099 6q25.1-q25.2 human K299-ac 459092 WPSPLMIkRSKKNSL protein stabilization cell growth, inhibited; cell motility, inhibited; transcription, induced 30787391; 33544437 4 3 0 MOF depletion promotes proliferation, motility and invasion in HCC -POLR2A POLR2A EC 2.7.7.48; EC 2.7.7.6; Nucleotide Metabolism - purine; Nucleotide Metabolism - pyrimidine; Transcription initiation complex; Transferase P24928 5430 17p13.1 human T1618-gl 6778600 QSPSYSPtSPSYSPT RNA_pol_Rpb1_R enzymatic activity, inhibited 11425311 2 0 0 glycosylation inhibits activity of CDK7 (CAK) -PLEC Plectin-1 Cytoskeletal; Motility/polarity/chemotaxis Q15149 5339 8q24.3 human S4642-p 3196844 RAGSRRGsFDATGSG molecular association, regulation; intracellular localization cytoskeletal reorganization K18(DISRUPTS); Vimentin(DISRUPTS); K14(DISRUPTS); desmin(DISRUPTS); NFH(DISRUPTS); K8(DISRUPTS); NFL(DISRUPTS); K5(DISRUPTS) 23843618 1 28 110 disrupts binding to intermediate filaments -MEF2A MEF2A DNA-binding; Motility/polarity/chemotaxis; Transcription factor Q02078 4205 15q26.3 human K403-ac 486379 TNQNISIkSEPISPP acetylation cell differentiation, inhibited; transcription, induced 16484498 1 0 0 switch from sumoylation to acetylsation -EZH2 EZH2 EC 2.1.1.43; METHYLTRANSFERASE; Methyltransferase; Methyltransferase, protein lysine Q15910 2146 7q36.1 human T367-p 466987 NNSSRPStPTINVLE molecular association, regulation; intracellular localization; enzymatic activity, induced carcinogenesis, induced; cell motility, induced; cell growth, inhibited; cell differentiation, induced; transcription, induced; cell motility, inhibited; transcription, inhibited YY1(INDUCES); P38A(INDUCES) 20887952; 27494834; 34685528; 35992062 5 21 45 induces p38 methylation and phosphorylation of p38 and AKT; inhibits H3 methylation; leads to nuclear localization through dephosphorylation of pT367; decreases H3K27 trimethylation -H2AC11 H2A.1 DNA-binding P0C0S8 8329 6p22.1 human K9-ac 480300 GRGKQGGkARAKAKT Histone transcription, altered 17560255 4 5 145 -RUNX3 AML2 DNA-binding; Transcription factor Q13761 864 1p36.11 human K94-ac 57676502 KTLPVAFkVVALGDV Runt molecular association, regulation apoptosis, induced; transcription, induced; signaling pathway regulation BRD2(INDUCES) 24229708 1 0 0 induces p14-p53 pathway -BAX BAX Apoptosis; Membrane protein, integral; Mitochondrial; Tumor suppressor Q07812 581 19q13.33 human S60-p 983100 DASTKKLsECLKRIG intracellular localization 17911107 1 0 0 -HNF4A HNF4 alpha DNA-binding; Nuclear receptor; Transcription factor P41235 3172 20q13.12 human K108-ac 460632 QCVVDKDkRNQCRYC zf-C4 molecular association, regulation; intracellular localization; protein conformation transcription, induced Exportin-1(DISRUPTS); CBP(INDUCES) DNA(INDUCES) 10882110 1 0 0 -Dpysl5 CRMP-5 Q9EQF6 65254 5|5 B1 mouse T509-p 478230 PGKKEMGtPLADTPT phosphorylation 29758318 1 11 1 S522A KI mice -DAXX DAXX Apoptosis; Nuclear receptor co-regulator; Nucleolus; Transcription, coactivator/corepressor Q9UER7 1616 6p21.32 human S739-p 467727 EIIVLSDsD______ sumoylation; molecular association, regulation apoptosis, altered; transcription, altered SUMO1(INDUCES); PML(INDUCES) 21474068 1 22 0 -Vim Vimentin Cytoskeletal; Motility/polarity/chemotaxis P20152 22352 2 A1|2 10.04 cM mouse S9-p 455450 STRSVSSsSYRRMFG Filament_head molecular association, regulation endocytosis, induced JAG1(INDUCES) 28533359 4 4 3 transendocytosis -APEX1 APE1 DNA repair, damage; DNA-binding; Deoxyribonuclease; EC 4.2.99.18; Endoplasmic reticulum; Hydrolase; Lyase; Nuclear receptor co-regulator; Nucleolus; Transcription, coactivator/corepressor P27695 328 14q11.2 human K35-ac 15207805 TAAKKNDkEAAGEGP molecular association, regulation; acetylation; intracellular localization; protein conformation; enzymatic activity, induced DNA repair, induced; cell growth, inhibited NPM1(DISRUPTS) RNA(DISRUPTS) 22918947 2 2 2 disrupts rRNA binding, induces acetylation at K6 and K7 -MAPT Tau iso8 ACETYLTRANSFERASE; Acetyltransferase; Cytoskeletal P10636-8 4137 17q21.31 human S356-gl 5227900 RVQSKIGsLDNITHV Tubulin-binding molecular association, regulation; protein conformation Tau iso8(DISRUPTS) 18671940 1 0 0 modulates aggregation of tau filaments -DNMT1 DNMT1 Amino Acid Metabolism - cysteine and methionine; Cell development/differentiation; EC 2.1.1.37; METHYLTRANSFERASE; Methyltransferase; Methyltransferase, DNA; Transcription regulation P26358 1786 19p13.2 human K1113-ac 466386 PGNKGKGkGKGKGKP cell cycle regulation; transcription, inhibited 21947282 1 4 2 -DYRK2 DYRK2 EC 2.7.12.1; KINASE; Kinase, protein; Protein kinase, CMGC; Protein kinase, dual-specificity (non-receptor) Q92630 8445 12q15 human S442-p 11489909 IELLGMPsQKLLDAS Pkinase enzymatic activity, induced apoptosis, altered 19965871 1 0 0 p53-mediated apoptosis -SUGT1 SUGT1 Cell cycle regulation; Ubiquitin conjugating system Q9Y2Z0 10910 13q14.3 human T265-p 455435 EGQGDVPtPKQFVAD protein stabilization; molecular association, regulation cell cycle regulation RNF41(INDUCES) 28696259 1 22 18 -LIMK1 LIMK1 EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, Ser/Thr (non-receptor); Protein kinase, TKL P53667 3984 7q11.23 human S307-p 3191869 DRSPGAGsLGSPASQ intracellular localization; enzymatic activity, induced cell cycle regulation; cytoskeletal reorganization 22214762 1 4 0 -CEBPB C/EBP-beta DNA-binding; Motility/polarity/chemotaxis; Transcription factor P17676 1051 20q13.13 human R3-m2 12626408 _____MQrLVAWDPA molecular association, regulation cell differentiation, inhibited; transcription, inhibited SMARCC1(DISRUPTS); MED23(DISRUPTS); SMARCB1(DISRUPTS); SMARCA2(DISRUPTS); MED26(DISRUPTS) 20111005 1 1 0 -Pdzd11 PDZD11 Adaptor/scaffold Q9CZG9 72621 X|X C3 mouse Y10-p 451588 NRIPYDDyPVVFLPA molecular association, regulation DECR1(INDUCES); ACAA2(INDUCES); TCERG1(INDUCES) 18268350 0 12 136 -DAPK2 DAPK2 EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, CAMK; Protein kinase, Ser/Thr (non-receptor) Q9UIK4 23604 15q22.31 human T369-p 487231 HPRRRSStS______ molecular association, regulation; phosphorylation 14-3-3 gamma(INDUCES); Calmodulin(DISRUPTS); DAPK2(INDUCES) 34413451 2 1 1 binding to 14-3-3 gamma induces DAPK2 dimerization, inhibits CaM-DAPK2 binding and DAPK2 dephosphorylation -SLC6A4 SERT Membrane protein, integral; Membrane protein, multi-pass; Transporter P31645 6532 17q11.2 human S48-p 1869992415 GQISNGYsAVPSPGA 5HT_transport_N receptor internalization, inhibited 32797733 1 0 0 -CORO7 coronin 7 Vesicle P57737 79585 16p13.3 human Y738-p 1871177707 PSTLLPSyDPDTGLV phosphorylation signaling pathway regulation 33162394 1 0 0 inhibits phosphorylation of YAP7 and hence the Hippo signaling pathway -TP53BP1 53BP1 DNA repair, damage; Transcription, coactivator/corepressor Q12888 7158 15q15.3 human T1609-p 486510 LGPYEAVtPLTKAAD activity, induced; molecular association, regulation; ubiquitination; intracellular localization cell cycle regulation; chromatin organization, altered; DNA repair, inhibited RNF168(DISRUPTS) 24703952 2 16 15 induce genome stability and Abrogates 53BP1 Foci in G1 Cells. Prevents the interaction of 53BP1 with chromatin. -Plcb1 PLCB1 Carbohydrate Metabolism - inositol phosphate; EC 3.1.4.11; Phospholipase P10687 24654 3q36 rat S887-p 450172 HSQPAPGsVKAPAKT activity, inhibited 11278470 3 1 0 -SET SET iso2 Apoptosis; DNA replication; DNA-binding; Inhibitor; Nuclear receptor co-regulator; Oncoprotein; Protein phosphatase, regulatory subunit Q01105-2 6418 9q34.11 human S9-p 6308300 SAPAAKVsKKELNSN receptor desensitization, induced; molecular association, regulation; intracellular localization; enzymatic activity, inhibited; phosphorylation signaling pathway regulation KPNA1(DISRUPTS); PPP2CA(INDUCES); KPNB1(DISRUPTS) 21419339; 23374587; 23926298 6 3 0 Phosphorylation of SET leads to PP2A inhibition which leads to Tau hyperphosphorylation; beta-2AR phosphorylation and signaling; oncogenic kinase Jak2V617F signaling and tumor suppressor (PP2A) activity; PP2A activity inhibited -H3F3C H3 DNA-binding P84229 427887 chicken K9-m2 459006 RTKQTARkSTGGKAP Histone transcription, inhibited 19950192 119 21 0 -MEF2C MEF2C DNA-binding; Transcription factor Q06413 4208 5q14.3 human K234-ac 12674408 VSPGNLNkNMQAKSP molecular association, regulation cell differentiation, induced; transcription, induced MRF(INDUCES) DNA(INDUCES) 15831463 1 0 0 -MAP2K5 MEK5 EC 2.7.12.2; KINASE; Kinase, protein; Protein kinase, STE; Protein kinase, dual-specificity (non-receptor) Q13163 5607 15q23 human T315-p 448622 LVNSIAKtYVGTNAY Pkinase molecular association, regulation; intracellular localization; enzymatic activity, induced ERK5(DISRUPTS) 14583600; 7759517 3 1 0 -MICAL2 MICAL2 Adaptor/scaffold; EC 1.14.13.- O94851 9645 11p15.3 human Y445-p 1875329206 LAERESLyRLLPQTT carcinogenesis, induced; cell motility, induced; cell growth, induced; cytoskeletal reorganization 34750518 1 1 0 -Pcna PCNA Cell cycle regulation; DNA replication P17918 18538 2 F2|2 64.15 cM mouse Y114-p 27281500 NQEKVSDyEMKLMDL PCNA_N cell cycle regulation; cell differentiation, induced 23201573; 28915506 2 0 2 distribution of body mass; Y114F +/+ mutant does not re-enter cell cycle for clonal expansion. Y114F+/+ mice are is resistant to diet-induced obesity compared to WT. -LIMK2 LIMK2 EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, Ser/Thr (non-receptor); Protein kinase, TKL P53671 3985 22q12.2 human S283-p 456167 EGTLRRRsLRRSNSI protein stabilization; intracellular localization cell adhesion, induced 15923181; 16820362; 22492986 4 1 10 -DVL2 DVL2 Adaptor/scaffold; Motility/polarity/chemotaxis O14641 1856 17p13.1 human K615-ub 15490613 EERAPESkSGSGSES Dsh_C molecular association, regulation; intracellular localization cell motility, induced; signaling pathway regulation Cofilin-1(INDUCES); VANGL1(INDUCES) 31340145 1 4 1 DVL2 variant with all encoded lysine residues mutated to arginine is sufficient to restore WNT activation -GNAT1 G-alpha t1 G protein; G protein, heterotrimeric; G protein, heterotrimeric alpha G((i/o/t/z)) P04695 281794 cow Y142-p 470102 CFDRASEyQLNDSAG G-alpha molecular association, regulation Src(INDUCES) 11032890 1 1 0 Tyrosine phosphorylation of GNAT1 increases association with Src. -H3-3A H3 DNA-binding Q71LE2 396970 pig K9-m3 1458613 RTKQTARkSTGGKAP Histone transcription, inhibited 32893712 137 24 1 mesenchymal stem/stroma cells of obese pigs had suppressed transcription compared to lean pigs -PLK1 PLK1 EC 2.7.11.21; KINASE; Kinase, protein; Protein kinase, Other; Protein kinase, Ser/Thr (non-receptor) P53350 5347 16p12.2 human K209-m1 1879811202 EYDGERKkTLCGTPN cell cycle regulation; DNA repair, induced 30854428 1 1 0 required for DNA damage repair; K209 peaks at S phase and may be required for DNA replication; K209 severely delays metaphase-to-anaphase transition -Sharpin SHARPIN Apoptosis Q91WA6 106025 15 D3|15 35.75 cM mouse K169-ub 54221303 QSSGNFKkEELATRL signaling pathway regulation 26829767 1 1 0 regulation of TCR signaling-maintenance of immuno; ogical signaling K63-linked polyubiquitination -Nefl NFL Cytoskeletal P08551 18039 14|14 D1 mouse S44-p 27430100 RSAYSSYsAPVSSSL Filament_head molecular association, regulation; intracellular localization 14-3-3 gamma(INDUCES) 23230147 1 0 0 regulates NF-L dynamic exchange rate and neurofilament disassembly -CEACAM3 CEACAM3 Cell adhesion; Immunoglobulin superfamily; Membrane protein, integral P40198 1084 19q13.2 human Y241-p 1879727800 LKHDTNIyCRMDHKA endocytosis, induced 35850306 1 0 0 induces phagocytosis -SLC9A3 NHE3 Membrane protein, integral; Membrane protein, multi-pass; Transporter; Transporter, SLC family P48764 6550 5p15.33 human S663-p 457469 TMRKRLEsFKSTKLG intracellular localization 25855080 4 1 2 trafficking of NHE3 to the apical membrane -PRKDC DNAPK DNA repair, damage; EC 2.7.11.1; KINASE; Kinase, protein; Nucleolus; Protein kinase, Ser/Thr (non-receptor); Protein kinase, atypical P78527 5591 8q11.21 human S2056-p 455794 VQSYSYSsQDPRPAT DNAPKcs_CC3 activity, induced; molecular association, regulation; intracellular localization; phosphorylation; enzymatic activity, induced cell cycle regulation; carcinogenesis, induced; carcinogenesis, inhibited; cell growth, inhibited; signaling pathway regulation; DNA repair, induced; chromatin organization, altered; apoptosis, inhibited; DNA repair, inhibited; cell growth, altered EphA2(INDUCES) DNA(INDUCES) 17189255; 19071136; 21653549; 24687855; 24844881; 25818648; 26603896; 31679687; 31980741; 32085396; 33671073; 33879618; 35740300; 35798878; 35972384; 36183837; 36755959 53 4 3 -PA2G4 Ebp1 Nuclear receptor co-regulator; Nucleolus; Transcription, coactivator/corepressor Q9UQ80 5036 12q13.2 human S34-p 35542202 IANRVLRsLVEASSS Peptidase_M24 carcinogenesis, induced; cell differentiation, induced; apoptosis, inhibited 25154617 1 0 0 -Mitf MITF DNA-binding; Oncoprotein; Transcription factor Q08874 17342 6 D3|6 45.05 cM mouse K289-sm 3590701 PANLPNIkRELTACI transcription, inhibited 16029420 3 1 0 -Met Met EC 2.7.10.1; KINASE; Kinase, protein; Membrane protein, integral; Oncoprotein; Protein kinase, TK; Protein kinase, tyrosine (receptor) P16056 17295 6 A2|6 7.83 cM mouse Y1228-p 448866 FGLARDMyDKEYYSV PK_Tyr_Ser-Thr enzymatic activity, induced 19595710 7 11 108 -LCP2 SLP76 Adaptor/scaffold Q13094 3937 5q35.1 human S376-p 476784 SSFPQSAsLPPYFSQ protein degradation; molecular association, regulation; ubiquitination transcription, altered 14-3-3 zeta(INDUCES); 14-3-3 epsilon(INDUCES); 14-3-3 gamma(INDUCES) 17353368; 22902619 5 1 0 -XRCC5 Ku80 DNA-binding; EC 3.6.1.-; EC 3.6.4.-; Helicase; Nuclear receptor co-regulator; Nucleolus; RNA-binding P13010 7520 2q35 human K534-ub 15391478 QIPLSKIkTLFPLIE Ku_C molecular association, regulation DNA repair, induced DNA(DISRUPTS) 27895153 1 7 3 -HBP1 HBP1 DNA-binding; Transcription factor O60381 26959 7q22.3 human K305-ac 25171017 LDHPFYVkNKGWSSF AXH transcription, inhibited 23249948 2 0 0 acetylation of the five sites induces transcriptional repression of the DNMT1 gene, regulates cellular senescence -GLI1 GLI1 C2H2-type zinc finger protein; Oncoprotein; Transcription factor P08151 2735 12q13.3 human K180-sm 1873076602 PFPTCQLkSELDMLV protein stabilization; ubiquitination; intracellular localization cell growth, induced; transcription, induced; signaling pathway regulation 28630282 1 0 0 inhibits ubiquitination, enhances Shh signaling -Casp4 CASP4 Apoptosis; EC 3.4.22.64; Protease P70343 12363 9 A1|9 2.46 cM mouse K63-ub 1877676803 VFVDAMKkKHSKVGE CARD protein degradation 30816303 1 0 0 -CIC capicua DNA-binding; Transcription factor Q96RK0 23152 19q13.2 human S173-p 3209781 PGKRRTQsLSALPKE protein degradation; molecular association, regulation; ubiquitination; intracellular localization transcription, induced; transcription, altered 14-3-3 theta(INDUCES); 14-3-3 epsilon(INDUCES); PJA1(INDUCES) DNA(INDUCES) 21087211; 30737375; 33103082 3 40 9 -TP53 p53 Activator; DNA-binding; Motility/polarity/chemotaxis; Nuclear receptor co-regulator; Transcription factor; Tumor suppressor P04637 7157 17p13.1 human T55-p 450685 DDIEQWFtEDPGPDE TAD2 activity, induced; protein degradation; molecular association, regulation; ubiquitination; intracellular localization; protein conformation; activity, inhibited cell cycle regulation; carcinogenesis, induced; apoptosis, altered; apoptosis, induced; transcription, induced; signaling pathway regulation; transcription, altered; cell growth, induced; apoptosis, inhibited; transcription, inhibited S100B(INDUCES); TFB1M(INDUCES); S100A1(INDUCES); S100A4(INDUCES); GTF2H1(INDUCES); Exportin-1(INDUCES); S100A6(INDUCES); SERCA2(DISRUPTS); MDM2(INDUCES); S100A2(INDUCES) DNA(DISRUPTS) 11409876; 15053879; 15116093; 16793543; 17245430; 18160537; 18952844; 19819244; 20124405; 22525275; 23723076; 24289924; 26029824; 28673515; 29988038; 33256128; 33443163; 33745968; 34798143 24 0 0 arsenic induced overexpression of PUMA, P53 phosphorylation and acetylation, activation and accumulation of p53, PUMA disruption of Bcl-X complexes with pro-survival proteins resulting in apoptosis -Ssh2 SSH2 Actin-binding; EC 3.1.3.16; EC 3.1.3.48; PHOSPHATASE; Protein phosphatase, dual-specificity Q5SW75 237860 11|11 B5 mouse S21-p 17544228 TTSSPCAsEADSGEE enzymatic activity, inhibited cytoskeletal reorganization; cell motility, inhibited 22172670 1 1 0 -Jak2 JAK2 EC 2.7.10.2; KINASE; Kinase, protein; Oncoprotein; Protein kinase, TK; Protein kinase, tyrosine (non-receptor) Q62120 16452 19 C1|19 23.73 cM mouse Y221-p 451493 VRAKIQDyHILTRKR FERM_F2 enzymatic activity, induced 15143187; 25002528 14 5 1 -WIPF1 WIPF1 Actin-binding; Motility/polarity/chemotaxis O43516 7456 2q31.1 human S154-p 23073655 PGRFPVPsPGHRSGP cell growth, induced 28166194 1 2 6 -RELA NFkB-p65 DNA-binding; Nuclear receptor co-regulator; Transcription factor Q04206 5970 11q13.1 human T352-gl 5148301 APQPYPFtSSLSTIN molecular association, regulation; intracellular localization transcription, induced IkB-alpha(DISRUPTS) DNA(INDUCES) 18988733; 25915426 3 2 0 -MAD2L1BP MAD2L1BP Cell cycle regulation Q15013 9587 6p21.1 human S102-p 1245332 KHFYRKPsPQAEEML p31comet molecular association, regulation; enzymatic activity, inhibited cell cycle regulation Mad2(DISRUPTS) 24596092; 31118282 2 14 3 promotes SAC activity in mitosis -MECOM EVI1 C2H2-type zinc finger protein; Methyltransferase, protein lysine, predicted; Oncoprotein; Transcription regulation; Transcription, coactivator/corepressor Q03112 2122 3q26.2 human S726-p 4703001 PLKMEPQsPGEVKKL molecular association, regulation cell motility, induced; cell growth, induced; transcription, induced DNA(INDUCES) 23858473 1 11 0 -MAF MAF Cell development/differentiation; DNA-binding; Oncoprotein; Transcription factor; Tumor suppressor O75444 4094 16q23.2 human K350-ub 37043500 AYKEKYEkLVSSGFR bZIP_Maf protein stabilization transcription, induced 25448412 1 0 0 -Prkaca PKACA EC 2.7.11.11; KINASE; Kinase, protein; Protein kinase, AGC; Protein kinase, Ser/Thr (non-receptor) P27791 25636 19q11 rat T198-p 448459 RVKGRTWtLCGTPEY Pkinase signaling pathway regulation 23490331 34 48 277 diabetes-type1 and type2-related signaling in brain -Arhgef7 ARHGEF7 GEF; GEF, Rac/Rho; Motility/polarity/chemotaxis O55043 114559 16q12.5 rat T526-p 455216 EFAVRKStAALEEDA RhoGEF67_u2 molecular association, regulation; intracellular localization cytoskeletal reorganization 14-3-3 beta(INDUCES) 15513924; 18160719 7 6 1 binding to 14-3-3 beta requires protein dimerization; translocated to Focal complexes -DGCR8 DGCR8 Nucleolus; RNA processing; RNA-binding Q8WYQ5 54487 22q11.21 human S275-p 3208080 GGDSDHPsDGETSVQ protein stabilization 24239349 1 36 4 -TJP2 ZO2 Adaptor/scaffold; Motility/polarity/chemotaxis Q95168 403854 dog S257-gl 28700304 PDARHAGsRSRSREH protein degradation; intracellular localization; phosphorylation 23804652 1 0 0 GlcNAcylated S257 is no longer phosphorylated and directed to TJs, instead becomes degraded -Ilf3 NFAT90 DNA-binding; Nucleolus; RNA-binding; Transcription factor Q9Z1X4 16201 9 A3|9 7.78 cM mouse T315-p 17734000 RQQREDItQSAQHAL DZF molecular association, regulation; intracellular localization translation, altered ILF2(DISRUPTS) 21123651 3 0 0 -ATG4B ATG4B Autophagy; EC 3.4.22.-; Protease; Ubiquitin conjugating system Q9Y4P1 23192 2q37.3 human S392-p 470322 DEDFEILsL______ molecular association, regulation; enzymatic activity, induced autophagy, induced LC3A(INDUCES) 26378241 2 8 0 -Traf3ip2 TRAF3IP2 Apoptosis; UBIQUITIN LIGASE; Ubiquitin conjugating system; Ubiquitin ligase Q8N7N6 103213 10|10 B1 mouse S147-p 25687507 ESDKSDPsLPNALAD molecular association, regulation transcription, inhibited TRAF6(DISRUPTS) 22851696 1 0 0 -USP10 USP10 DEUBIQUITINASE; EC 3.4.19.12; Protease; RNA-binding; Ubiquitin conjugating system; Ubiquitin-specific protease Q14694 9100 16q24.1 human T674-p 10801134 VEISRRVtLEKLPPV UCH intracellular localization 34983926 1 0 1 inhibits AID degradation -Slc12a5 KCC2 iso2 Membrane protein, integral; Membrane protein, multi-pass; Transporter; Transporter, SLC family Q91V14-2 57138 2|2 H3 mouse T1006-p 10045602 TDPEVHLtWTKDKSV neural plasticity 31396048 9 5 1 regulates hyperpolarizing synaptic inhibition and adulthood cognitive function -TP53 p53 Activator; DNA-binding; Motility/polarity/chemotaxis; Nuclear receptor co-regulator; Transcription factor; Tumor suppressor P04637 7157 17p13.1 human K382-ub 464658 QSTSRHKkLMFKTEG protein degradation; molecular association, regulation; intracellular localization transcription, inhibited ING1(DISRUPTS) 11046142; 17371868; 19927155; 21731648; 31002112 10 0 0 K370/372/373/381/382/386/R mutant shows 613-fold activation of p53; binds unmodified or six multimonoubiquitinated forms of wild-type p53; translocation of p53 from the nucleus to the cytoplasm, promotes EMT in EOC cells -ESR1 ER-alpha DNA-binding; Nuclear receptor; Transcription factor P03372 2099 6q25.1-q25.2 human S341-p 33663900 TRPFSEAsMMGLLTN Hormone_recep protein degradation; molecular association, regulation; ubiquitination cell cycle regulation; transcription, induced SKP2(INDUCES) 23770852 1 0 0 ERalpha-SKP2 binding caused degradation of ERalpha -Irf3 IRF3 DNA-binding; Transcription factor P70671 54131 7|7 B3 mouse S388-p 449028 KTVDLHIsNSQPISL intracellular localization; enzymatic activity, induced transcription, induced 24270516; 33941660; 34161773; 34433039; 34969857; 35320000 75 6 0 -H3C1 H3 DNA-binding P68431 8350 6p22.2 human K9-m3 1458613 RTKQTARkSTGGKAP Histone sumoylation; molecular association, regulation; intracellular localization cell cycle regulation; cell differentiation, inhibited; apoptosis, induced; cell motility, induced; cell adhesion, induced; transcription, induced; transcription, altered; cell differentiation, altered; DNA repair, induced; cell differentiation, induced; cell growth, induced; chromatin organization, altered; cytoskeletal reorganization; transcription, inhibited UHRF1(INDUCES); CDYL2(INDUCES); ZNF828(INDUCES); HSFY1(INDUCES); MAD2L2(INDUCES); HP1 alpha(INDUCES); WDR42A(INDUCES); DNMT1(INDUCES); CBX3(INDUCES); CBX1(INDUCES); Tip60(INDUCES); ORC2(INDUCES); AGO3(INDUCES); CHD-4(INDUCES); POGZ(INDUCES); ZNF470(INDUCES); RCOR1(DISRUPTS); CDYL(INDUCES) DNA(INDUCES) 16732292; 16732293; 16858404; 17066076; 17237781; 17968314; 18004385; 18234970; 18701507; 18835819; 19021773; 19022177; 19546172; 19624289; 19706462; 19783983; 19811652; 19889207; 20070858; 20159609; 20221260; 20404330; 20613843; 20716953; 20850016; 21059703; 21156283; 21489993; 24292684; 28674400; 29370823; 31015297; 32232334; 32675241; 32908309; 34720086; 35322029; 36461911 137 24 1 -GAK GAK Cell cycle regulation; EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, Other; Protein kinase, Ser/Thr (non-receptor) O14976 2580 4p16.3 human Y412-p 63063501 KGDLDISyITSRIAV cell cycle regulation 28135906 1 0 0 -PTTG1 Securin Cell cycle regulation; Oncoprotein O95997 9232 5q33.3 human S183-p 20764101 SNLLQSPsSILSTLD Securin protein degradation cell cycle regulation 21757741 2 0 0 -Camk2b CAMK2B EC 2.7.11.17; KINASE; Kinase, protein; Protein kinase, CAMK; Protein kinase, Ser/Thr (non-receptor) P08413 24245 14q21 rat S367-p 456904 KNSSAITsPKGSLPP molecular association, regulation 26291163 1 14 1 inhibits interaction with F-actin, regulates synaptic plasticity -PTEN PTEN Carbohydrate Metabolism - inositol phosphate; EC 3.1.3.16; EC 3.1.3.48; EC 3.1.3.67; Motility/polarity/chemotaxis; Nuclear receptor co-regulator; PHOSPHATASE; Phosphatase, lipid; Tumor suppressor P60484 5728 10q23.31 human K163-ac 3833098 GEVRTRDkKGVTIPS intracellular localization; protein conformation; phosphorylation carcinogenesis, inhibited; cell growth, inhibited; cell motility, inhibited 26279303 1 0 1 inhibits AKT phosphorylation -WAC WAC Adaptor/scaffold Q9BTA9 51322 10p12.1|10p12.1-p11.2 human T244-p 36128588 AETHSSStPVQHPIK molecular association, regulation; phosphorylation cell cycle regulation PLK1(INDUCES) 30021153 1 1 0 -DDR1 DDR1 EC 2.7.10.1; KINASE; Kinase, protein; Membrane protein, integral; Protein kinase, TK; Protein kinase, tyrosine (receptor) Q08345 780 6p21.33 human Y703-p 462887 PLCMITDyMENGDLN PK_Tyr_Ser-Thr molecular association, regulation SHP-2(INDUCES) 16611743 1 0 0 required for the DDR1-mediated suppression of tyrosine phosphorylation of Stat1 and Stat3, cell migration, branching tubulogenesis -Mknk1 Mnk1 EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, CAMK; Protein kinase, Ser/Thr (non-receptor); Translation O08605 17346 4|4 D1 mouse T209-p 447621 NSCTPITtPELTTPC Pkinase molecular association, regulation; enzymatic activity, induced eIF4G(INDUCES) 10022874 14 1 1 -SPDEF SPDEF DNA-binding; Motility/polarity/chemotaxis; Nuclear receptor co-regulator; Transcription factor O95238 25803 6p21.31 human S242-p 54165903 WTDSEVDsSCSGQPI protein degradation cell motility, induced 26885618 1 0 0 enhances migration and invasion of prostate cancer cells -HMGN1 HMGN1 DNA-binding; Nuclear receptor co-regulator P05114 3150 21q22.2 human K3-ac 458843 _____MPkRKVSSAE HMG14_17 molecular association, regulation DNA(DISRUPTS) 10753971 2 0 0 -MRE11 MRE11A Cell cycle regulation; DNA repair, damage; DNA-binding; Deoxyribonuclease P49959 4361 11q21 human R587-me 2344811 RGQNSASrGGSQRGR intracellular localization 15970667 2 0 0 localizes in nucleus and associates with nuclear bodies and sites of DNA damage -WWP2 WWP2 EC 6.3.2.-; EC 6.3.2.19; Ligase; UBIQUITIN LIGASE; Ubiquitin conjugating system; Ubiquitin ligase O00308 11060 16q22.1 human Y369-p 464298 TAEYVRNyEQWQSQR enzymatic activity, induced autophagy, induced 35331737 1 2 12 -HDAC9 HDAC9 DEACETYLASE; Deacetylase; EC 3.5.1.98; Transcription, coactivator/corepressor Q9UKV0 9734 7p21.1 human S220-p 448485 FPLRKTAsEPNLKVR molecular association, regulation; intracellular localization 14-3-3 beta(INDUCES) 20188095 3 19 25 -BCL2L11 BIM Apoptosis O43521 10018 2q13 human T116-p 449071 SCDKSTQtPSPPCQA molecular association, regulation autophagy, induced; apoptosis, inhibited LC8(DISRUPTS); beclin 1(DISRUPTS); MCL1(INDUCES); Bcl-2(INDUCES) 22742832; 34193942 10 1 0 -ERO1A ERO1L EC 1.8.4.-; Oxidoreductase; Secreted; Secreted, signal peptide Q96HE7 30001 14q22.1 human S145-p 36122817 GAVDESLsEETQKAV ERO1 intracellular localization; protein conformation; enzymatic activity, induced 29858230 1 4 0 regulates ER redox, promotes oxidative folding of proteins -HIPK2 HIPK2 EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, CMGC; Protein kinase, Ser/Thr (non-receptor) Q9H2X6 28996 7q34 human K671-ub 3059904 GLQASPSkHAGYSVR protein degradation 18536714 1 0 0 -Gria2 GluR2 Channel, calcium; Channel, ligand-gated; Membrane protein, integral; Membrane protein, multi-pass P19491 29627 2q33 rat S880-p 448351 YNVYGIEsVKI____ molecular association, regulation; ubiquitination; intracellular localization; receptor internalization, altered; receptor recycling, altered; activity, inhibited GRIP1(DISRUPTS) 10856222; 11007883; 14534256; 17145504; 18077702; 19279258; 32052226 30 1 0 Ser-880 is su?cient but is not necessary for the augmentation of bicuculline-induced GluA2 ubiquitination -VWF VWF Cell adhesion; Extracellular matrix; Motility/polarity/chemotaxis; Secreted; Secreted, signal peptide P04275 7450 12p13.31 human S1613-p 1867984205 MVTGNPAsDEIKRLP VWA cell adhesion, induced 30864273 1 1 0 increases platelet adhesion under shear conditions -Irak2 IRAK2 KINASE; Kinase, protein; Protein kinase, Ser/Thr (non-receptor); Protein kinase, TKL Q8CFA1 108960 6 E3|6 52.82 cM mouse T140-p 18262495 KPRSLLDtGPIMAGA molecular association, regulation; intracellular localization signaling pathway regulation PHB(INDUCES); OPA1(INDUCES); TIMM50(INDUCES) 32778760 1 2 0 IL-1R?MyD88?IRAK2?PHB/OPA1 signaling pathway -MMP14 MMP14 EC 3.4.24.80; Membrane protein, integral; Motility/polarity/chemotaxis; Protease P50281 4323 14q11.2 human Y573-p 478362 GTPRRLLyCQRSLLD DUF3377 molecular association, regulation; intracellular localization cell cycle regulation; carcinogenesis, induced; carcinogenesis, altered; cell motility, altered; transcription, induced; cell growth, altered P130Cas(INDUCES); FAK(INDUCES) 17389600; 18621744; 19509114; 20651331; 22291036; 23548906 7 3 39 peptide antagonist (ACM-14) carrying mutation (Y573F) of this site inhibits tumor cell proliferation ; MMP14 overexpression induces CSF-2, CSF-3 gene expression and requires Y573-p.; ECM degradation at focal adhesions -Ptk2 FAK EC 2.7.10.2; KINASE; Kinase, protein; Protein kinase, TK; Protein kinase, tyrosine (non-receptor) P34152 14083 15 D3|15 33.94 cM mouse S843-p 447963 DVRLSRGsIDREDGS phosphorylation 15845548 7 14 7 decreases phosphorylation at FAK Tyr397 -Polb POLB DNA repair, damage; DNA replication; EC 2.7.7.7; Lyase; Transferase P06766 29240 16q12.5 rat S55-p 41521701 KYPHKIKsGAEAKKL HHH_8 enzymatic activity, inhibited 2040602 3 0 0 -NR5A1 STF-1 Nuclear receptor; Transcription, coactivator/corepressor Q13285 2516 9q33.3 human S203-p 447603 EYPEPYAsPPQPGLP activity, induced; molecular association, regulation transcription, induced PITX1(INDUCES) 14596681; 17901130; 19995909; 35592512 11 0 0 -H3-4 HIST3H3 DNA-binding Q16695 8290 1q42.13 human K79-m1 8113918 REIAQDFkTDLRFQS Histone molecular association, regulation L3MBTL iso4(INDUCES) 23583077 0 4 37 -FPR1 FPR1 GPCR, family 1; Membrane protein, integral; Membrane protein, multi-pass; Motility/polarity/chemotaxis; Receptor, GPCR P21462 2357 19q13.41 human T336-p 450844 TQTSDTAtNSTLPSA receptor desensitization, altered; receptor internalization, altered 10514456 2 1 0 -NACA NACA Motility/polarity/chemotaxis; Transcription, coactivator/corepressor E9PAV3 4666 12q13.3 human T2022-p 451197 NIQENTQtPTVQEES protein stabilization; intracellular localization transcription, altered 15005626 1 13 0 -PIK3CB PIK3CB Carbohydrate Metabolism - inositol phosphate; EC 2.7.1.153; KINASE; Kinase, lipid; Motility/polarity/chemotaxis P42338 5291 3q22.3 human K952-sm 1881459301 FKSKFGIkRERVPFI protein stabilization signaling pathway regulation 33834259 1 0 0 PI3K signaling pathway, PI3K regulatory subunit p85-beta inhibits K952 SUMOylation -Camk2b CAMK2B EC 2.7.11.17; KINASE; Kinase, protein; Protein kinase, CAMK; Protein kinase, Ser/Thr (non-receptor) P08413 24245 14q21 rat S358-p 15719516 GVKPQTNsTKNSSAI molecular association, regulation 26291163 1 2 0 inhibits interaction with F-actin, regulates synaptic plasticity -Stx7 STX7 Membrane protein, integral; Vesicle O70439 53331 10|10 A4 mouse S129-p 468882 VRASSRVsGGFPEDS molecular association, regulation STX8(INDUCES); VTI1B(INDUCES); VAMP8(INDUCES) 18710945 1 45 189 -HDAC9 HDAC9 DEACETYLASE; Deacetylase; EC 3.5.1.98; Transcription, coactivator/corepressor Q9UKV0 9734 7p21.1 human S451-p 448486 RPLNRTQsAPLPQST molecular association, regulation; intracellular localization 14-3-3 beta(INDUCES) 20188095 3 5 6 -SLC12A1 NKCC2 Membrane protein, integral; Membrane protein, multi-pass; Transporter; Transporter, SLC family Q13621 6557 15q21.1 human T105-p 458228 LQTFGHNtMDAVPKI AA_permease_N activity, induced signaling pathway regulation 21321328 14 2 0 WNK-SPAK-OSR1 pathway -PNPLA8 PNPLA8 EC 3.1.1.5; Membrane protein, integral; Motility/polarity/chemotaxis; Phospholipase Q9NP80 50640 7q31.1 human S511-p 18638838 ELYRKLGsDVFSQNV Patatin activity, induced; enzymatic activity, induced transcription, induced; signaling pathway regulation 23258543; 25492867 2 1 0 Increase PGE2 release and leads to conformational change in the enzyme; ATF6 activation -USP16 USP16 DEUBIQUITINASE; EC 3.4.19.12; Protease; Ubiquitin conjugating system; Ubiquitin-specific protease Q9Y5T5 10600 21q21.3 human S415-p 3217536 VEDEDQDsEEEKDND UCH protein degradation 28380042 1 40 0 -Map2 MAP2 iso3 Cytoskeletal; Motility/polarity/chemotaxis P15146-3 25595 9q32 rat K311-ac 36300530 NQPLPDLkNVKSKIG Tubulin-binding cytoskeletal reorganization 28002468 1 2 0 -Tsc2 TSC2 iso2 Cell cycle regulation; GAP; GAP, misc.; Nuclear receptor co-regulator; Tumor suppressor P49816-2 24855 10q12 rat S1211-p 448807 TALYKSLsVPAAGTA molecular association, regulation 14-3-3 beta(INDUCES) 12364343 6 23 14 -SDCBP syntenin Adaptor/scaffold; Cell adhesion; Cytokine; Membrane protein, integral; Motility/polarity/chemotaxis; Vesicle O00560 6386 8q12.1 human T200-p 1869341900 RPFERTItMHKDSTG Peptidase_M50; PDZ protein stabilization; molecular association, regulation carcinogenesis, induced; signaling pathway regulation Src(INDUCES); EGFR(INDUCES); FAK(INDUCES) 32572158 1 0 0 AURKA-SDCBP-EGFR-PI3K-AKT pathway; Inhibits ubiquitination -Cdk16 CDK16 Cell cycle regulation; EC 2.7.11.22; KINASE; Kinase, protein; Motility/polarity/chemotaxis; Protein kinase, CMGC; Protein kinase, Ser/Thr (non-receptor) Q04735 18555 X A1.3|X 16.18 cM mouse S153-p 453451 SRRLRRVsLSEIGFG molecular association, regulation; intracellular localization CBCP1(DISRUPTS); CCNYL1(DISRUPTS) 22184064; 26305884 3 58 166 -Bex1 BEX1 Cell cycle regulation; Cell development/differentiation Q3MKQ2 501625 Xq35 rat S105-p 14788300 KLRERQLsHSLRAVS BEX protein stabilization 16498402 1 1 0 -Srebf1 SREBP-1 iso1 DNA-binding; Membrane protein, integral; Membrane protein, multi-pass; Transcription factor P56720-1 78968 10q22 rat S419-p 56654316 LGSRGSSsGGSDSEP protein stabilization; molecular association, regulation; intracellular localization transcription, induced SCAP(INDUCES) 31541353 1 2 0 activates genes involved in de novo lipogenesis -LAIR1 LAIR-1 Membrane protein, integral; Receptor, misc. Q6GTX8 3903 19q13.42 human Y251-p 449020 GSSQEVTyAQLDHWA molecular association, regulation signaling pathway regulation CSK(INDUCES); SHP-1(INDUCES) 10764762; 31932281 2 1 39 TCR signaling/suppression of TCR signaling -CPSF3 CPSF3 EC 3.1.27.-; RNA processing; RNA splicing; RNA-binding; Ribonuclease Q9UKF6 51692 2p25.1 human K545-sm 2586337 EELEIQEkPALKVFK CPSF73-100_C RNA splicing, altered; cell growth, induced 17923699 1 0 0 regulation of mRNA 3'-end processing- cleavage and polyadenylation -SASS6 SAS6 Cell cycle regulation Q6UVJ0 163786 1p21.2 human T495-p 15414716 DVLGPSTtPPAHSSS molecular association, regulation; intracellular localization cell cycle regulation NEDD1(DISRUPTS); STIL(DISRUPTS) 36356903 1 2 1 -PARP1 PARP1 DNA repair, damage; EC 2.4.2.30; Nuclear envelope; Nuclear receptor co-regulator; Nucleolus; Transferase P09874 142 1q42.12 human S179-p 481744 FRPEYSAsQLKGFSL zf-PARP enzymatic activity, inhibited 33811702 1 8 6 regulates necrotic cell death/ necrosis -KLF2 KLF2 C2H2-type zinc finger protein; DNA-binding Q9Y5W3 10365 19p13.11 human K148-sm 31089515 TRGPRGLkREGAPGP transcription, inhibited 23515309 1 0 0 -RIGI RIGI EC 3.6.4.13; Hydrolase O95786 23586 9p21.1 human K154-ub 7761219 GMMAGAEkLVECLLR CARD_2 transcription, induced 19484123 1 0 0 induces DDX58-mediated innate antiviral activity -Map2 MAP2 iso3 Cytoskeletal; Motility/polarity/chemotaxis P15146-3 25595 9q32 rat K337-ac 62495511 GQVQIVTkKIDLSHV Tubulin-binding cytoskeletal reorganization 28002468 1 1 0 -CKAP4 CKAP4 Endoplasmic reticulum; Membrane protein, integral Q07065 10970 12q23.3 human S17-p 455354 KGGHGAAsPSEKGAH molecular association, regulation; intracellular localization; palmitoylation neural plasticity; cell growth, inhibited; cytoskeletal reorganization; transcription, altered; signaling pathway regulation DNA(INDUCES) 15703217; 22265418; 22536245 3 12 0 -MVB12B FAM125B Vesicle Q9H7P6 89853 9q33.3 human Y241-p 6209987 RNSTRTDyEYQHSNL DUF2464 protein degradation; ubiquitination 20654576 1 0 3 -Rptor Raptor Adaptor/scaffold Q8K4Q0 74370 11|11 E2 mouse S1189-p 23137513 VAGLGDGsIRVYDRR WD40 protein degradation; molecular association, regulation; ubiquitination cell growth, inhibited; signaling pathway regulation USP9X(DISRUPTS) 37395713 1 0 1 inhibits mTORC1 pathway -Themis THEMIS Cell development/differentiation Q8BGW0 210757 10|10 A4 mouse Y542-p 27806313 EEITEEQyYMMRRYE cell differentiation, induced 23460737 1 1 0 thymocyte development -Ephb2 EphB2 EC 2.7.10.1; KINASE; Kinase, protein; Membrane protein, integral; Protein kinase, TK; Protein kinase, tyrosine (receptor); Tumor suppressor P54763 13844 4 D3|4 69.0 cM mouse Y930-p 448334 EAIKMGQyKESFANA SAM_1 molecular association, regulation GRB10(INDUCES) 8798570 3 2 0 necessary for binding to Grb10 SH2, but not Grb2. -Mapk7 ERK5 EC 2.7.11.24; KINASE; Kinase, protein; Protein kinase, CMGC; Protein kinase, Ser/Thr (non-receptor) Q9WVS8 23939 11|11 B2 mouse Y221-p 448206 HQYFMTEyVATRWYR Pkinase carcinogenesis, induced; cell adhesion, induced; signaling pathway regulation 33687949 20 28 955 ERK5/ P70S6K/RAC1 pathway -L1CAM NCAM-L1 Cell adhesion; Membrane protein, integral P32004 3897 Xq28 human S1181-p 465573 GEYRSLEsDNEEKAF Bravo_FIGEY molecular association, regulation; intracellular localization; phosphorylation cell motility, altered; cytoskeletal reorganization; cell adhesion, inhibited ANK3(INDUCES) 17151951; 17253643; 19720049; 29109170 6 23 5 L1 sensitivity to ethanol; axonal growth -Etv4 ETV4 DNA-binding P28322 18612 11 D|11 65.48 cM mouse K442-ac 26373308 DNQRPALkAEFDRPV sumoylation transcription, induced 21543453 1 1 0 acetylated sites inhibits sumoylation reciprocally -CDCP1 CDCP1 Cell surface; Membrane protein, integral Q9H5V8 64866 3p21.31 human Y734-p 451434 KDNDSHVyAVIEDTM molecular association, regulation; intracellular localization; phosphorylation carcinogenesis, induced; cell growth, induced; cell motility, induced; cell adhesion, induced; cell motility, altered; cytoskeletal reorganization Src(INDUCES); PKCD(INDUCES); SHP-2(INDUCES) 14739293; 15851033; 20501830; 21725358; 21994943; 23300860; 25728678; 25876044 10 3 12 Tyr734 is a key precursor phosphorylation event allowing Tyr707 and Tyr806 phosphorylation -Hspb6 HSP20 Chaperone; Heat shock protein Q5EBG6 243912 7|7 B1 mouse S16-p 450706 PSWLRRAsAPLPGFS Crystallin activity, induced; molecular association, regulation; intracellular localization; protein processing; activity, inhibited apoptosis, altered; cell growth, induced; cell differentiation, induced; apoptosis, inhibited; transcription, induced; cytoskeletal reorganization; signaling pathway regulation PPA1(INDUCES); HSP20(DISRUPTS) 19850943; 20854253; 23713735; 24244723; 30845231; 31061921 21 31 2 regulates IL-6/STAT3 signaling pathway; differentiation ?broblasts to myo?broblasts, fibrotic remodeling; increase IL-6 expression; inhibit endoplasmic reticulum OGD/R -related structural changes and Golgi apparatus OGD/R -related fragmentation; Reduced mitochondrial fragmentation. Bcl-2 expression increased, Bax expression decreased.; nuclear translocation of STAT3; increases the level of Golgi stress-related proteins but decreases the level ER stress-related proteins -Gata1 GATA1 DNA-binding; Transcription factor P17679 14460 X A1.1|X 3.59 cM mouse S26-p 451232 VDSALVSsPSDSTGF activity, induced; protein degradation; acetylation; molecular association, regulation; ubiquitination; phosphorylation cell differentiation, inhibited; apoptosis, inhibited; transcription, induced LMO2(INDUCES) DNA(INDUCES) 15167914; 15967790; 16858405; 23717580 6 0 0 -Pik3c3 PIK3C3 Autophagy; Carbohydrate Metabolism - inositol phosphate; EC 2.7.1.137; Kinase, lipid; Motility/polarity/chemotaxis Q6PF93 225326 18|18 B1 mouse T159-p 14659500 DGSEPTRtPGRTSST PI3K_C2 neural plasticity; endocytosis, inhibited 35318705 2 0 0 -ATF5 ATF-5 DNA-binding Q9Y2D1 22809 19q13.33 human K29-ac 20745204 GWLVDYGkLPPAPAP molecular association, regulation carcinogenesis, induced; cell growth, induced; apoptosis, inhibited; transcription, induced DNA(INDUCES) 21791614; 28473657 2 0 0 Enhanced cell survival -CCNE2 CCNE2 Activator; Cell cycle regulation O96020 9134 8q22.1 human T74-p 5996402 SPCIIIEtPHKEIGT protein degradation; ubiquitination 19084516 1 3 4 -CAMK2G CAMK2G EC 2.7.11.17; KINASE; Kinase, protein; Protein kinase, CAMK; Protein kinase, Ser/Thr (non-receptor) Q13555 818 10q22.2 human S334-p 4770259 GGVKKRKsSSSVHLM intracellular localization 25303525 1 2 1 dephosphorylation of S334 of CaMKIIG necessary for its nuclear translocation -Stat1 STAT1 DNA-binding; Transcription factor Q9QXK0 25124 9q22 rat Y701-p 447754 DDPKRTGyIKTELIS activity, induced; molecular association, regulation apoptosis, inhibited; transcription, altered DNA(INDUCES) 11309387; 14984365; 21102409 204 7 64 -CACNA1C CACNA1C Channel, calcium; Membrane protein, integral; Membrane protein, multi-pass Q13936 775 12p13.33 human S1535-p 460572 DYLTRDWsILGPHHL Ion_trans protein conformation 29123182 5 1 0 increased calcium influx through the channel -ARPC1B ARPC1B Cytoskeletal; Motility/polarity/chemotaxis O15143 10095 7q22.1 human T21-p 10349703 HAWNKDRtQIAICPN molecular association, regulation; phosphorylation cell cycle regulation; cell motility, altered; cytoskeletal reorganization ARPC2(INDUCES); ARP2(INDUCES) 14749719; 20603326 3 1 0 stimulates T288 AurA phosphorylation and its activation -Ogt OGT EC 2.4.1.255; Glycan Metabolism - O-glycan biosynthesis; O-GlcNAc TRANSFERASE; Transferase P56558 26295 Xq22 rat T444-p 31828209 EAIASYRtALKLKPD TPR_11 activity, induced; intracellular localization 24563466 1 1 0 modifies substrate specificity of OGT; induce AMPK activity -NUMA1 NuMA-1 Cell cycle regulation; Motility/polarity/chemotaxis Q14980 4926 11q13.4 human S1887-p 3196640 TRSSARRsQAGVSSG cell growth, induced; apoptosis, inhibited 23097092 1 12 35 cell proliferation increased -DNAJB2 DNAJB2 Chaperone P25686 3300 2q35 human S247-p 34505486 PASCPLDsDLSEDED molecular association, regulation 28031292 1 3 0 phosphorylation reduced its ability to bind ubiquitylated clients, and chaperone activity -Ahcyl1 AHCYL1 Amino Acid Metabolism - cysteine and methionine; EC 3.3.1.1; Hydrolase; Other Amino Acids Metabolism - selenoamino acid Q80SW1 229709 3 F2.3|3 46.83 cM mouse S77-p 467249 SSTDSYSsAASYTDS molecular association, regulation PIP4K2A(INDUCES); IP3R1(INDUCES) 16793548; 26509711 4 0 0 -H3c1 H3 DNA-binding P68433 360198 13|13 A3.1 mouse T11-p 455680 KQTARKStGGKAPRK Histone acetylation; intracellular localization DNA repair, induced; transcription, induced GCN5(INDUCES) 18243098 17 5 0 recruitment to promoters, H3-K9 acetylation -Cacna1c CACNA1C Channel, calcium; Membrane protein, integral; Membrane protein, multi-pass P22002 24239 4q42 rat Y1787-p 880751701 STFTPSSySSTGSNA CAC1F_C activity, induced 29441404 1 0 0 significantly increased the Ca2+current density of CACNA1C channels in a range of the membrane potentials -Cav2 caveolin-2 Adaptor/scaffold; Motility/polarity/chemotaxis Q2IBC5 363425 4q21 rat Y27-p 454430 SHHSVVDyTDPEKYV Caveolin molecular association, regulation; intracellular localization; phosphorylation IRS1(INDUCES) 19427337; 25667086 6 9 33 -CRYAB CRYAB Chaperone; Heat shock protein P02511 1410 11q23.1 human S19-p 447728 RPFFPFHsPSRLFDQ Crystallin activity, induced; protein degradation; molecular association, regulation; intracellular localization; activity, inhibited; protein conformation exocytosis, inhibited; apoptosis, inhibited FBXO4(INDUCES); CASP7(INDUCES); CRYAB(DISRUPTS); CASP3(INDUCES); GEMIN3(INDUCES); CASP2(DISRUPTS) 11096101; 12468532; 15511225; 16928191; 18061612; 23049853; 24023879; 26620801; 27641668; 36232565 26 16 2 -Tfap2a AP-2 alpha DNA-binding; Transcription factor P34056 21418 13 A3.3|13 20.01 cM mouse S219-p 25581601 CSVPGRLsLLSSTSK TF_AP-2 activity, induced transcription, induced 28179583 3 0 0 -CD22 CD22 Cell surface; Membrane protein, integral P20273 933 19q13.12 human Y807-p 450943 HKRQVGDyENVIPDF molecular association, regulation GRB2(INDUCES) 34526379 6 0 1 -ZEB2 ZEB2 C2H2-type zinc finger protein; DNA-binding; Motility/polarity/chemotaxis; Transcription, coactivator/corepressor O60315 9839 2q22.3 human K391-sm 3726900 QTGLLKIkTEPLDFN molecular association, regulation transcription, induced CTBP1(DISRUPTS) 16061479 1 2 0 -TNIP1 TNIP1 Transcription regulation Q15025 10318 5q33.1 human Y552-p 25790900 CGAYPYAyPPMPAMV molecular association, regulation cell adhesion, induced SELPLG(INDUCES); PIK3R1(INDUCES) 17632516 1 0 0 activation of alpha-M beta-2 integrin -Map3k12 DLK EC 2.7.11.25; KINASE; Kinase, protein; Protein kinase, Ser/Thr (non-receptor); Protein kinase, TKL Q60700 26404 15|15 F3 mouse S533-p 27447446 RNVPQKLsPHSKRPD protein stabilization 23979718 1 5 0 -GCSAM GCET2 Unknown function Q8N6F7 257144 3q13.2 human Y106-p 463673 SGNSAEEyYENVPCK HGAL activity, induced signaling pathway regulation 31362927 1 2 22 regulates B cell receptor signaling -CCR5 CCR5 GPCR, family 1; Membrane protein, integral; Membrane protein, multi-pass; Motility/polarity/chemotaxis; Receptor, GPCR; Receptor, cytokine P51681 1234 3p21.31 human Y339-p 2431400 PERASSVyTRSTGEQ phosphorylation 16809330 1 0 0 necessary for vaccina virus infection and subsequent ERK, IRS-2, and GRB2 phosphorylation -Pawr PAR-4 Apoptosis Q62627 64513 7q21 rat T155-p 456964 LREKRRStGVVNIPA apoptosis, induced; transcription, altered 15657440 3 1 31 -ESRRA ERR1 DNA-binding; Nuclear receptor; Transcription regulation P11474 2101 11q13.1 human K51-ub 1877015601 TRCLPGHkEEEDGEG protein degradation cell differentiation, inhibited 31907393 1 0 0 -IRF7 IRF7 DNA-binding; Transcription factor Q92985 3665 11p15.5 human K446-ub 4666608 SAGRPKEkSLVLVKL IRF-3 transcription, induced 18710948 1 0 0 -Mob1b MOB1B Activator; Protein kinase, regulatory subunit Q8BPB0 68473 5|5 E1 mouse T35-p 3545001 LLKHAEAtLGSGNLR Mob1_phocein activity, induced; molecular association, regulation; protein conformation LATS1(INDUCES) 27335147 3 47 34 -TBK1 TBK1 EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, Other; Protein kinase, Ser/Thr (non-receptor) Q9UHD2 29110 12q14.2 human K154-ub 15398587 EDGQSVYkLTDFGAA Pkinase molecular association, regulation; enzymatic activity, induced transcription, induced; signaling pathway regulation IKKG(INDUCES) 23028469 1 5 1 RIG-I-mediated antiviral defense and IFN-activation signaling -CDKN1B p27Kip1 Cell cycle regulation; Inhibitor; Oncoprotein; Protein kinase, regulatory subunit P46527 1027 12p13.1 human S2-gl 55595400 ______MsNVRVSNG protein degradation; intracellular localization cell cycle regulation; cell growth, induced Exportin-1(INDUCES) 27175940 1 1 0 translocated into the cytoplasm -Klf7 KLF7 C2H2-type zinc finger protein; DNA-binding Q99JB0 93691 1|1 C2 mouse K231-ac 56423806 GCRKVYTkSSHLKAH zf-C2H2 cell cycle regulation; cell growth, inhibited; transcription, induced 26930448 1 0 0 -ARHGAP33 SNX26 GAP; GAP, Rac/Rho; Vesicle O14559 115703 19q13.12 human Y406-p 465993 PLLTYQLyGKFSEAM RhoGAP activity, inhibited cell growth, altered 16777849 1 0 0 -HIF1A HIF1A Autophagy; DNA-binding; Transcription factor Q16665 3091 14q23.2 human K12-ac 25126717 GGANDKKkISSERRK protein degradation transcription, inhibited 21917920; 28319066 2 0 0 -Prkab1 AMPKB1 Autophagy; KINASE; Protein kinase, regulatory subunit P80386 83803 12q16 rat S24-p 448111 HKTPRRDsSGGTKDG intracellular localization 11171104 4 6 11 -Ikbkb IKKB EC 2.7.11.10; KINASE; Kinase, protein; Protein kinase, Other; Protein kinase, Ser/Thr (non-receptor) O88351 16150 8|8 A2 mouse Y188-p 449632 SFVGTLQyLAPELLE Pkinase phosphorylation; enzymatic activity, induced cell differentiation, induced; signaling pathway regulation 20534585; 30514903 6 0 0 Y188/199 of IKK? and Y179 TBK1 phosphorylation induce activation of TLR signaling; osteoclast differentiation -Ncam1 NCAM1 Cell adhesion; Membrane protein, GPI anchor; Membrane protein, integral; Motility/polarity/chemotaxis P13595 17967 9 A5.3|9 26.83 cM mouse S1113-p 456507 TQTKENEsKA_____ activity, induced 15953420 1 0 0 Phosphorylated peptide (but not unphosphorylated form) causes a larger number of transmission failures and acts as a dominant negative to the protein (similar to the null). This region of NCAM1 appears to signal through the MLCK-MLC pathway (induces MLC phosphorylation) in a putative myosin II-mediated process. -H4C1 H4 DNA-binding P62805 8359 6p22.2 human K8-ac 458959 SGRGKGGkGLGKGGA protein degradation; protein stabilization; molecular association, regulation; methylation cell cycle regulation; carcinogenesis, induced; cell growth, inhibited; apoptosis, induced; transcription, induced; transcription, altered; DNA repair, induced; cell growth, induced; chromatin organization, altered; cell differentiation, induced TBN(INDUCES); BRDT(INDUCES); CGI-09(INDUCES); BRD7(INDUCES); PUS1(INDUCES); BRD2(DISRUPTS); SETD8(DISRUPTS); THOC4(INDUCES); TAF4(INDUCES) DNA(DISRUPTS) 11387442; 15456746; 17498659; 17530637; 17560255; 18179771; 18418072; 18628788; 18985155; 19805290; 19883641; 20043883; 20048151; 20720004; 21047799; 21726812; 22978410; 23297421; 23653357; 23970329; 27508876; 31071955; 31822509; 31881804; 33087562; 35876654 85 21 529 LINC00839 promotes oxidative phosphorylation (OXPHOS), mitochondrial biogenesis and CRC progression; PRMT5 knockdow changes in the chromatin structure of all three target miRNA promoters to promote their transcription; HDACi panobinostat induced apoptosis in K562 and K562-IR cells; in acidic pH-adapted cells -MUC1 MUC1 Actin-binding; Cell adhesion; Membrane protein, integral; Motility/polarity/chemotaxis; Nuclear receptor co-regulator; Tumor suppressor P15941 4582 1q22 human S1227-p 455675 PPSSTDRsPYEKVSA molecular association, regulation CTNNB1(DISRUPTS) 9819408 1 7 17 -Grin1 NMDAR1 Channel, calcium; Channel, ligand-gated; Membrane protein, integral; Membrane protein, multi-pass P35439 24408 3p13 rat T900-p 11080321 RRRSSKDtSTGGGRG activity, inhibited 21163614 1 0 1 phosphomimetic mutations increased sensitivity to inhibition by ethanol -Csnk1d CK1D EC 2.7.11.1; EC 2.7.11.26; KINASE; Kinase, protein; Protein kinase, CK1; Protein kinase, Ser/Thr (non-receptor) Q06486 64462 10q32.3 rat S328-p 3190837 PATRGLPsTASGRLR enzymatic activity, inhibited 23861943; 26803658 2 13 1 -PLSCR3 PLSCR3 Membrane protein, integral Q9NRY6 57048 17p13.1 human T21-p 457790 PPPPYPVtPGYPEPA apoptosis, induced 16267027 1 0 1 -Sirt1 SIRT1 Apoptosis; DEACETYLASE; Deacetylase; EC 3.5.1.-; Nuclear receptor co-regulator Q923E4 93759 10|10 B4 mouse S46-p 452899 DGPGLGRsPGEPSAA protein degradation; ubiquitination 21540183 8 49 9 -SMAD1 SMAD1 DNA-binding; Transcription factor Q15797 4086 4q31.21 human S195-p 451174 PNSSYPNsPGSSSST intracellular localization 9335504 3 0 0 Erk-mediated phosphorylation inhibits the nuclear accumulation of Smad1. -DCD DCD EC 3.4.-.-; Secreted; Secreted, signal peptide P81605 117159 12q13.2 human Y20-p 18752500 AGALVCAyDPEAASA Dermcidin molecular association, regulation cell motility, altered NCK1(INDUCES) 21397687 1 0 0 -MAFA MAFA DNA-binding; Oncoprotein; Transcription factor; Tumor suppressor Q8NHW3 389692 8q24.3 human S61-p 1320401 PLSTPCSsVPSSPSF protein degradation; molecular association, regulation; ubiquitination carcinogenesis, induced; transcription, induced PCAF(INDUCES) 18042454 4 0 0 -GBF1 GBF1 GEF; GEF, ARF Q92538 8729 10q24.32 human S297-p 1170755601 TDSGLEFsSQTTSKE protein degradation; molecular association, regulation; ubiquitination; intracellular localization cell cycle regulation; cytoskeletal reorganization BTRC(INDUCES) 29898406 1 1 0 -Mapt Tau ACETYLTRANSFERASE; Acetyltransferase; Cytoskeletal P10637 17762 11 67.79 cM|11 E1 mouse S527-p 449080 VVRTPPKsPSASKSR phosphorylation neural plasticity 27834631; 33428131 45 36 25 -Siah2 SIAH2 EC 6.3.2.-; EC 6.3.2.19; Ligase; Transcription, coactivator/corepressor; UBIQUITIN LIGASE; Ubiquitin conjugating system; Ubiquitin ligase Q06986 20439 3 D|3 28.68 cM mouse S29-p 471339 PQTPHAPsPAAPPAA molecular association, regulation; intracellular localization EGLN3(INDUCES) 17003045 6 2 0 plays a role in degradation of endogenous EGLN3 (PHD3). -Ago2 AGO2 EC 3.1.26.n2; RNA processing; RNA-binding Q8CJG0 239528 15|15 D3 mouse Y394-p 17533102 ASFNTDPyVREFGIM ArgoL2 molecular association, regulation translation, induced RNA(INDUCES) 35439023 8 2 0 -EFNB2 EFNB2 Ligand, receptor tyrosine kinase; Membrane protein, integral P52799 1948 13q33.3 human Y304-p 451679 DSVFCPHyEKVSGDY molecular association, regulation; protein conformation NCK2(INDUCES) 15096211 1 22 240 Y304 phosphopeptide can also bind (simultaneously) to PDZ domain of RGS3; not phosphorylation-dependent -Tln1 talin 1 Cytoskeletal; Motility/polarity/chemotaxis P26039 21894 4|4 A5 mouse K2454-m3 40800300 DQDSEAMkRLQAAGN I_LWEQ molecular association, regulation ACTB(DISRUPTS) 25751747 2 1 0 promoted cleavage of talin -Akt1 Akt1 EC 2.7.11.1; KINASE; Kinase, protein; Oncoprotein; Protein kinase, AGC; Protein kinase, Ser/Thr (non-receptor) P31750 11651 12 F1|12 61.2 cM mouse S129-p 450019 SGSPSDNsGAEEMEV carcinogenesis, induced; signaling pathway regulation 32473126 13 48 2 FAK-p-HGFR-p-Akt-p-p65-CCL2 FAK-p-HGFR-p-Akt-p-p65-CCL2 -MAP4 MAP4 Cytoskeletal; Motility/polarity/chemotaxis P27816 4134 3p21.31 human K718-ac 62495524 KTSTSKAkTQPTSLP cytoskeletal reorganization 28002468 1 1 0 -FOXO1 FOXO1A DNA-binding; Nuclear receptor co-regulator; Oncoprotein; Transcription factor Q12778 2308 13q14.11 human S249-p 471071 EGGKSGKsPRRRAAS molecular association, regulation; intracellular localization; activity, inhibited cell cycle regulation; cell growth, induced; apoptosis, induced; apoptosis, inhibited; transcription, induced; transcription, inhibited; transcription, altered 14-3-3 beta(INDUCES) 17038621; 18356527; 18408765; 23469153; 23995784 13 2 2 -SLC4A1 SLC4A1 Membrane protein, integral; Membrane protein, multi-pass; Transporter; Transporter, SLC family P02730 6521 17q21.31 human Y21-p 457533 ENLEQEEyEDPDIPE molecular association, regulation LYN(INDUCES); ANK1(DISRUPTS) 10942405; 27856737 6 2 0 -AR AR DNA-binding; Nuclear receptor; Transcription factor P10275 367 Xq12 human R761-me 56394108 SFTNVNSrMLYFAPD Hormone_recep activity, inhibited cell growth, induced; transcription, inhibited 27183006 1 1 0 -Rims1 RIMS1 Adaptor/scaffold; Vesicle Q9JIR4 84556 9q13 rat S346-p 477744 RRLEKGRsQDYSDRP neural plasticity 35443170 1 7 1 -MARK3 MARK3 iso3 EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, CAMK; Protein kinase, Ser/Thr (non-receptor) P27448-3 4140 14q32.32-q32.33 human T95-p 3597305 DKTQLNPtSLQKLFR Pkinase enzymatic activity, inhibited 15319445 1 0 0 -TUBA1A TUBA1A Cytoskeletal; Motility/polarity/chemotaxis Q71U36 7846 12q13.12 human K311-me 1877356500 KCDPRHGkYMACCLL Tubulin_C molecular association, regulation; intracellular localization TFCP2(INDUCES) 32111740 1 1 0 TFCP2 recruits SETD8 to tubulin and enhances K311 methylation, while the inhibitor FQI1 inhibits TFCP2 methylation. -ACBD5 ACBD5 iso2 Lipid-binding; Membrane protein, integral Q5T8D3-2 91452 10p12.1 human S259-p 1876128608 TGIQHLTsDSDSEVY molecular association, regulation; phosphorylation VAPB(INDUCES) 35019937 1 1 0 induces phosphorylation at S269 -KHSRP KHSRP RNA-binding Q92945 8570 19p13.3 human S395-p 1876620110 DLLQSLRsGPPGPPG molecular association, regulation carcinogenesis, induced; RNA splicing, inhibited RNA(DISRUPTS) 35240233 1 1 0 -Nkx2-2 NKX2-2 Cell development/differentiation; Transcription factor P42586 18088 2 G2|2 72.63 cM mouse S199-p 51389258 MEVTPLPsPRRVAVP cell differentiation, inhibited 31932307 1 4 0 -KCNH2 Kv11.1 Channel, potassium; Membrane protein, integral; Membrane protein, multi-pass; Motility/polarity/chemotaxis Q12809 3757 7q36.1 human S890-p 3893409 RQRKRKLsFRRRTDK activity, induced; protein stabilization; intracellular localization; activity, inhibited signaling pathway regulation 10488078; 10837251; 22653970 4 0 3 -IP6K2 IHPK2 EC 2.7.4.21; Kinase, other; Motility/polarity/chemotaxis Q9UHH9 51447 3p21.31 human S356-p 18258507 AEDLEDLsEESADES IPK protein degradation; ubiquitination 21262846 1 2 0 -PTPN1 PTP1B EC 3.1.3.48; Motility/polarity/chemotaxis; PHOSPHATASE; Phosphatase; Protein phosphatase, tyrosine (non-receptor) P18031 5770 20q13.13 human Y152-p 449312 ISEDIKSyYTVRQLE Y_phosphatase molecular association, regulation INSR(INDUCES) 8999839 5 0 1 -Stk39 STLK3 EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, STE; Protein kinase, Ser/Thr (non-receptor) O88506 54348 3q21 rat S380-p 456506 VRRVPGSsGHLHKTE activity, induced 21553016 20 20 1 NKCC2 activity regulation/ increased -STAT5B STAT5B DNA-binding; Oncoprotein; Transcription factor P51692 6777 17q21.2 human K681-ac 62484403 PKDEVYSkYYTPVPC phosphorylation transcription, induced 23980167 1 0 0 increases pSTAT5B at Y699 -KLF8 KLF8 C2H2-type zinc finger protein; DNA-binding; Transcription factor O95600 11279 Xp11.21 human S48-p 56672701 EYRSNMTsPTLLDAN molecular association, regulation; protein stabilization; ubiquitination cell motility, induced; transcription, induced NEDD4(INDUCES) 27293988; 30972179 2 0 0 The phosphorylated form of KLF8 is ubiquitinated and degraded to protect the unphosphorylated form from degradation -DSP Desmoplakin Cell adhesion; Cytoskeletal; Motility/polarity/chemotaxis P15924 1832 6p24.3 human K2066-ub 52490401 IDPHRNEkLTVDSAI Plectin protein degradation 26676607 0 2 0 -GRIK2 GluR6 Channel, calcium; Channel, ligand-gated; Membrane protein, integral; Membrane protein, multi-pass Q13002 2898 6q16.3 human Y590-p 36320701 RFSPYEWyNPHPCNP Lig_chan activity, induced; receptor internalization, induced; protein conformation endocytosis, induced 25201974 1 0 0 activation of JNK3?c-Jun signaling. -ATP5F1A ATP5A1 EC 3.6.3.14; Energy Metabolism - oxidative phosphorylation; Hydrolase; Membrane protein, integral; Mitochondrial; Transporter P25705 498 18q21.1 human K506-ac 7248095 LEPSKITkFENAFLS ATP-synt_ab_C cell growth, inhibited 32002124 1 4 4 tumor growth inhibited (increased in K506/531R mutant) -Braf BRAF EC 2.7.11.1; KINASE; Kinase, protein; Oncoprotein; Protein kinase, Ser/Thr (non-receptor); Protein kinase, TKL F1M9C3 114486 4q22 rat S483-p 447804 KTLGRRDsSDDWEIP phosphorylation 26333016 15 44 87 constitutively phosphorylated -Agtr1 AT1 GPCR, family 1; Membrane protein, integral; Membrane protein, multi-pass; Receptor, GPCR P25095 24180 17p12 rat Y319-p 448745 YFLQLLKyIPPKAKS activity, induced; molecular association, regulation EGFR(INDUCES) 12522132 5 0 0 AT1-EGFR interaction is inhibited by dominant negative SHP-2. Y319 phosphorylation increased angiotensin II induced proliferation. -FMNL2 FMNL2 Cytoskeletal Q96PY5 114793 2q23.3 human T202-p 4689209 HSALRYNtLPSRRTL cytoskeletal reorganization 25456499 1 6 1 spine development -Frs2 FRS2 Adaptor/scaffold Q8C180 327826 10|10 D2 mouse Y436-p 448154 LEHRQLNyIQVDLEG molecular association, regulation SHP-2(INDUCES) 9632781 6 1 0 -EMD emerin Cytoskeletal; Membrane protein, integral P50402 2010 Xq28 human Y19-p 10897601 LTTLLRRyNIPHGPV LEM molecular association, regulation BAF(INDUCES) 19789182 1 1 0 -Grin1 NMDAR1 Channel, calcium; Channel, ligand-gated; Membrane protein, integral; Membrane protein, multi-pass P35438 14810 2 A3|2 17.14 cM mouse S897-p 448256 SFKRRRSsKDTSTGG neural plasticity; signaling pathway regulation 33301817 27 0 0 A2aR-PKA-Rap1-MAPK signaling pathway -PTPN6 SHP-1 EC 3.1.3.48; Motility/polarity/chemotaxis; PHOSPHATASE; Protein phosphatase, tyrosine (non-receptor) P29350 5777 12p13.31 human Y564-p 448912 SKHKEDVyENLHTKN molecular association, regulation; enzymatic activity, induced cell adhesion, inhibited; transcription, inhibited; signaling pathway regulation SH3BP2(INDUCES); GRB2(INDUCES); PIK3R1(INDUCES) 10488096; 12468540; 14551136; 14699166; 16649996; 34010642 18 19 776 -NIFK NIFK Nucleolus; RNA-binding Q9BYG3 84365 2q14.3 human T238-p 449333 QGPTPVCtPTFLERR hNIFK_binding molecular association, regulation KI-67(INDUCES) 11342549 2 27 75 -PDHA1 PDHA1 Amino Acid Metabolism - valine, leucine and isoleucine biosynthesis; Carbohydrate Metabolism - butanoate; Carbohydrate Metabolism - citrate (TCA) cycle; Carbohydrate Metabolism - glycolysis and gluconeogenesis; Carbohydrate Metabolism - pyruvate; EC 1.2.4.1; Mitochondrial; Oxidoreductase P08559 5160 Xp22.12 human K321-ac 461155 SDPIMLLkDRMVNSN E1_dh molecular association, regulation; phosphorylation cell growth, induced PDK1(INDUCES) 24486017; 25104357 2 10 74 glycolysis, cancer cell proliferation ; induces phosphorylation at S293 -SP1 SP1 C2H2-type zinc finger protein; DNA-binding; Transcription factor P08047 6667 12q13.13 human S59-p 452233 GGQESQPsPLALLAA O-GlcNAc glycosylation; protein degradation; molecular association, regulation; ubiquitination; intracellular localization cell motility, induced; transcription, inhibited; transcription, altered RNF4(INDUCES) DNA(INDUCES) 17049555; 18239466; 19318349; 21097497; 28574228; 35124373 6 16 0 negatively controls SP1 glycosylation; nuclear localization, promotes EMT; regulates cellular senescence; decreases SP1 association with chromatin; increased PPP2CA amounts in SLE T cells mediate S59-dephosphorylation and functional activation of SP1 -PPARGC1A PGC-1 alpha Nuclear receptor co-regulator; Transcription, coactivator/corepressor Q9UBK2 10891 4p15.2 human T263-p 448241 TTLSLPLtPESPNDP protein stabilization 11741533 2 0 0 -Hdac6 HDAC6 DEACETYLASE; Deacetylase; EC 3.5.1.98; Nuclear receptor co-regulator; Ubiquitin conjugating system XP_228753 84581 Xq12 rat S21-p 453006 KSRHNPQsPLQDSSA enzymatic activity, induced 20520769 5 35 18 -Mapk8ip1 JIP1 Adaptor/scaffold Q9WVI9 19099 2|2 E1 mouse Y278-p 234613501 LEATEEIyLTPVQRP molecular association, regulation VAV1(INDUCES) 28930674 1 0 0 -FOXO4 FOXO4 DNA-binding; Oncoprotein; Transcription factor P98177 4303 Xq13.1 human S262-p 448517 TFRPRSSsNASSVST intracellular localization transcription, inhibited 10217147; 11313479 5 0 2 -Scn5a SCN5A Channel, sodium; Membrane protein, integral; Membrane protein, multi-pass Q9JJV9 20271 9 F3|9 71.33 cM mouse S571-p 27281507 PWPLRRPsTQGQPGF Na_trans_cytopl activity, induced; enzymatic activity, induced 24812278; 26187182; 31622781 10 4 0 Induce and regulate Atrial fibrillation, increase calcium mediated arrhythmia and regulates atrial myocyte late Na current and membrane excitability -Ppp2r1a PPP2R1A Motility/polarity/chemotaxis; PHOSPHATASE; Protein phosphatase, regulatory subunit Q5XI34 117281 1q12 rat S314-p 31006102 KEFCENLsADCRENV molecular association, regulation; protein conformation PPP2CA(DISRUPTS) 24465463 1 1 0 defect in holoenzyme assembly -IGFBP3 IGFBP3 Cell development/differentiation; Secreted; Secreted, signal peptide P17936 3486 7p12.3 human S194-p 10902818 KVDYESQsTDTQNFS phosphorylation apoptosis, altered 19556345 1 0 0 inhibits JNK phosphorylation and apoptosis -Nfatc1 NFAT2 DNA-binding; Transcription factor O88942 18018 18 E3|18 53.66 cM mouse K549-ac 25350100 NSDIELRkGETDIGR RHD_DNA_bind activity, induced; molecular association, regulation transcription, induced DNA(INDUCES) 21498542 1 0 0 -Atoh1 ATOH1 Cell development/differentiation; DNA-binding; Transcription factor P48985 11921 6 C1|6 30.03 cM mouse S339-p 34425603 HRSDGEFsPHSHYSD protein stabilization; molecular association, regulation transcription, inhibited HUWE1(INDUCES) 24960692 2 2 0 -UBA52-RPS27A-UBB-UBC ubiquitin Ubiquitin-like modifier P62991 mouse K48-ub 486303 QRLIFAGkQLEDGRT ubiquitin protein degradation; molecular association, regulation; protein stabilization; ubiquitination cell differentiation, inhibited; autophagy, induced; transcription, inhibited ALDH2(INDUCES) 29263902; 31061531; 31076723; 31270148; 31534008; 32024978; 33976225; 34039738; 35354308; 35900990; 36261549 109 50 157 USP22 promotes the degradation of NLRP3 via ATG5-mediated autophagy; K48 linked polyubiquitylation -Ermn ERMN Q5EBJ4 77767 2 C1.1|2 mouse T257-p 2049017 NSYSRYNtISYRKIR Ermin cytoskeletal reorganization 25456499 2 3 3 spine development -PARP1 PARP1 DNA repair, damage; EC 2.4.2.30; Nuclear envelope; Nuclear receptor co-regulator; Nucleolus; Transferase P09874 142 1q42.12 human K949-ac 36310561 PKGKHSVkGLGKTTP PARP protein stabilization DNA repair, induced 31616951 1 1 0 MORC2-mediated stabilization of PARP1 is implicated in PAR-dependent DNA repair. -YAP1 YAP1 iso3 Oncoprotein; Transcription, coactivator/corepressor P46937-3 10413 11q22.1 human S127-p 448847 PQHVRAHsSPASLQL intracellular localization 27013234; 34697383; 35015027 207 33 180 -Vax2 VAX2 DNA-binding; Transcription factor Q9WTP9 24113 6 C3|6 35.94 cM mouse S170-p 470130 RDLEKRAsSSASEAF intracellular localization 17043310 1 0 0 causes relocalization of Vax2 to cytoplasm; controls eye developement in mice -H4C1 H4 DNA-binding P62805 8359 6p22.2 human S47-p 449870 RGGVKRIsGLIYEET CENP-T_C molecular association, regulation chromatin organization, altered CAF-1A(DISRUPTS); ASF1B(INDUCES); DAXX(INDUCES); H3F3A(INDUCES); HIST3H3(INDUCES); ASF1A(INDUCES); HIRA(INDUCES) DNA(INDUCES) 21724829 3 70 0 -Npy1r NPY1R GPCR, family 1; Membrane protein, integral; Membrane protein, multi-pass; Receptor, GPCR P21555 29358 16p14 rat T353-p 2815304 YETIAMStMHTDVSK receptor desensitization, altered; receptor internalization, altered 15576634 1 0 1 may be an artifact of the truncation mutants -SIAH1 SIAH1 Apoptosis; Cell development/differentiation; EC 6.3.2.-; EC 6.3.2.19; Ligase; Motility/polarity/chemotaxis; UBIQUITIN LIGASE; Ubiquitin conjugating system; Ubiquitin ligase Q8IUQ4 6477 16q12.1 human T74-p 36694103 PKLTCCPtCRGPLGS molecular association, regulation; acetylation; intracellular localization signaling pathway regulation GAPDH(INDUCES) 25391652 1 0 0 augments p300 acetylation; nuclear translocation -PDC phosducin G protein regulator, misc. P19632 287007 cow K33-sm 2873900 INDWRKFkLESEDSD Phosducin protein stabilization; molecular association, regulation; ubiquitination signaling pathway regulation G-beta 4(DISRUPTS) 16421094 1 0 0 inhibits ubiquitination, regulates binding of G-beta-gamma to phosducin and G-protein-mediated signal transduction -PPP1R14A PPP1R14A Inhibitor; Protein phosphatase, regulatory subunit Q96A00 94274 19q13.2 human S12-p 10294800 RLGKRVLsKLQSPSR PP1_inhibitor intracellular localization 23541585 2 0 0 -PCGF1 PCGF1 EC 6.3.2.-; Ubiquitin conjugating system Q9BSM1 84759 2p13.1 human S195-p 2897400 QNKYVRCsVRAEVRH RAWUL transcription, inhibited 15620699 1 1 0 -MYC Myc DNA-binding; Nucleolus; Oncoprotein; Transcription factor P01106 4609 8q24.21 human Y89-p 17553985 SGLCSPSyVAVTPFS Myc_N intracellular localization cell growth, induced 23318434 2 1 0 pY74 is localized to the cytoplasm, and is critical for maximal Myc activity in cellular transformation. -Maf MAF Cell development/differentiation; DNA-binding; Oncoprotein; Transcription factor; Tumor suppressor P54843 17132 8 E1|8 62.61 cM mouse Y21-p 25673104 TSPLAMEyVNDFDLM molecular association, regulation transcription, induced DNA(INDUCES) 25993510 2 0 0 IL-4 and IL-21 induction -SLBP SLBP RNA-binding Q14493 7884 4p16.3 human S20-p 470507 SRCDGDAsPPSPARW protein degradation; ubiquitination 22907757 1 30 25 -DTYMK DTYMK EC 2.7.4.9; Kinase, other; Mitochondrial; Nucleotide Metabolism - pyrimidine P23919 1841 2q37.3 human S88-p 1253766700 PLIKEKLsQGVTLVV Thymidylate_kin molecular association, regulation; intracellular localization DNA repair, induced Tip60(INDUCES) DNA(INDUCES) 30199284 1 1 0 -TOP2B TOP2B iso2 Cell development/differentiation; DNA-binding; EC 5.99.1.3; Motility/polarity/chemotaxis; Nucleolus; Topoisomerase Q02880-2 7155 3p24.2 human S1134-p 34733062 SSDSGTPsGPDFNYI DNA_topoisoIV protein degradation; molecular association, regulation; ubiquitination carcinogenesis, induced BTRC(INDUCES) 32015321 1 1 1 -HIF1A HIF1A Autophagy; DNA-binding; Transcription factor Q16665 3091 14q23.2 human K532-ac 458961 SDMVNEFkLELVEKL protein degradation; molecular association, regulation; ubiquitination carcinogenesis, inhibited; cell motility, inhibited; transcription, inhibited VHL(INDUCES) DNA(INDUCES) 12464182; 14695184; 18574470; 20194889; 28534506 8 2 0 -TUBG1 TUBG1 Cytoskeletal; Motility/polarity/chemotaxis P23258 7283 17q21.2 human K48-ub 486349 ATEGTDRkDVFFYQA Tubulin cell cycle regulation; cytoskeletal reorganization 15367667; 16166645 2 4 0 -CD8A CD8A iso2 Membrane protein, integral P01732-2 925 2p11.2 human K190-ub 52485006 PVVKSGDkPSLSARY protein degradation 26676607 0 1 0 -HNRNPK hnRNP K RNA splicing; RNA-binding; Spliceosome P61978 3190 9q21.32 human R268-m2 26358525 FDRMPPGrGGRPMPP molecular association, regulation translation, inhibited RPS19(INDUCES) 33660773 1 3 1 suppression of ALOX15 mRNA translation initiation -Cav2 caveolin-2 Adaptor/scaffold; Motility/polarity/chemotaxis Q2IBC5 363425 4q21 rat Y19-p 450198 LFMADDAySHHSVVD Caveolin molecular association, regulation; intracellular localization; phosphorylation cell cycle regulation ERK2(INDUCES); ERK1(INDUCES); IRS1(INDUCES) 19427337; 19778377; 25667086 10 10 28 in response to insulin -KATNA1 KATNA1 EC 3.6.4.3; Hydrolase; Motility/polarity/chemotaxis O75449 11104 6q25.1 human S42-p 26401200 QMNKYLYsVKDTYLQ ubiquitination cell cycle regulation 19287380 1 0 0 -Bmpr1a BMPR1A EC 2.7.11.30; KINASE; Kinase, protein; Membrane protein, integral; Protein kinase, Ser/Thr (receptor); Protein kinase, TKL P36895 12166 14 B|14 20.81 cM mouse Y458-p 25655002 EEYQLPYyNMVPSDP PK_Tyr_Ser-Thr molecular association, regulation cell growth, induced; signaling pathway regulation BMPR2(INDUCES); TAB1(DISRUPTS) 22729085 1 1 0 regulation of BMP downstream pathways-Erk1/2 and Smad1 activation, regulates life span of osteoblasts (expansion) -HSPA5 GRP78 Chaperone; Heat shock protein; KINASE P11021 3309 9q33.3 human K118-ac 475591 DIKFLPFkVVEKKTK HSP70 molecular association, regulation; phosphorylation apoptosis, induced; signaling pathway regulation PERK(DISRUPTS) 20371724 1 2 0 induces phosphorylation of elf2a and activation of eIf2a-ATF4-CHOP pathway -TBX22 TBX22 DNA-binding Q9Y458 50945 Xq21.1 human K63-sm 2798305 EPLEKQPkTEPSTSA transcription, inhibited 17846996 1 0 0 -BECN1 beclin 1 Adaptor/scaffold; Autophagy; Membrane protein, peripheral Q14457 8678 17q21.31 human Y233-p 477225 EAQYQREySEFKRQQ APG6_N molecular association, regulation cell differentiation, inhibited; carcinogenesis, induced; autophagy, inhibited Bcl-2(INDUCES); ATG14(DISRUPTS); beclin 1(INDUCES); UVRAG(INDUCES); rubicon(INDUCES); PIK3C3(DISRUPTS) 24034250; 27994061; 29610308 3 0 0 kinase active HER2 -Mfn1 MFN1 EC 3.6.5.-; Hydrolase; Membrane protein, integral; Membrane protein, multi-pass; Mitochondrial Q8R4Z9 192647 2q24 rat T562-p 40416800 VPRSLAStPTAPSNP molecular association, regulation apoptosis, induced BAK1(INDUCES); MFN1(DISRUPTS) 25801171 1 0 0 inhibits its own oligomerization; modulate mitochondrail shape -Tp53 p53 Activator; DNA-binding; Motility/polarity/chemotaxis; Nuclear receptor co-regulator; Transcription factor; Tumor suppressor P02340 22059 11 B3|11 42.83 cM mouse K378-ac 458983 GQSTSRHkKTMVKKV activity, induced transcription, induced 33323382 35 6 0 P53K Q/- mice died prematurely due to anemia, loss of hematopoiesis stem cells, Loss of stem cells in the testis, activation in p53 KQ/- mice without robust p53 stabilization,p53-KQ/- mutant leads to effective suppression of tumor development in a pancreatic ductal adenocarcinoma mouse model, mutant proteins extended the life-span of a PDAC mouse model -RAB5B RAB5B G protein; G protein, monomeric; G protein, monomeric, Rab P61020 5869 12q13.2 human T6-p 38546301 __MTSRStARPNGQP activity, induced cell growth, induced 25605758 1 1 0 enhances Rab5 GTPase activity -Lpin1 LPIN1 EC 3.1.3.4; Phosphatase, lipid Q91ZP3 14245 12 A1.1|12 7.9 cM mouse S472-p 471355 GARSANQsPQSVGGS intracellular localization chromatin organization, altered; transcription, induced; signaling pathway regulation 21816276 2 7 0 SREBP pathway, regulates nuclear eccentricity -ACTB ACTB Cytoskeletal; Motility/polarity/chemotaxis P60709 60 7p22.1 human H73-me 1877656601 TLKYPIEhGIVTNWD Actin protein conformation 30760599 2 0 0 Methyl-H73 N+-H interaction with the side chain of R177 which allows the gamma-phosphate to escape -WWTR1 TAZ Oncoprotein; Transcription, coactivator/corepressor Q9GZV5 25937 3q25.1 human T285-p 41594200 AVNPPTMtPDMRSIT protein degradation 26183396 1 0 0 -Rcan1 RCAN1 Inhibitor Q6IN33 266766 11q11 rat S112-p 456023 FLISPPAsPPVGWKQ Calcipressin enzymatic activity, induced neural plasticity 32084406 7 38 6 induces calcineurin activity and hence LTD -APC APC Motility/polarity/chemotaxis; Tumor suppressor P25054 324 5q22.2 human S1507-p 452097 FSCSSSLsALSLDEP APC_r molecular association, regulation; phosphorylation CTNNB1(INDUCES) 12628243; 17910481 2 0 0 primes for phosphorylation of S1510 and S1507, by CK1 and GSK3B respectively; based on acidic phospho-mimetic mutant -LIN28B LIN28B Unknown function Q6ZN17 389421 6q16.3-q21 human S243-p 1870790709 EQSKKGPsVQKRKKT molecular association, regulation; intracellular localization carcinogenesis, induced; cell motility, induced; cell growth, induced; transcription, induced; signaling pathway regulation RNA(INDUCES) 33107691 1 0 0 induces binding to let-7i miRNA thus inducing the let-7/TET3 pathway -NFE2L2 NRF2 DNA-binding; Transcription factor Q16236 4780 2q31.2 human K548-ac 7106314 KEKGENDkSLHLLKK bZIP_Maf molecular association, regulation transcription, induced DNA(INDUCES) 19273602 1 1 0 -FOS Fos DNA-binding; Motility/polarity/chemotaxis; Oncoprotein; Transcription factor P01100 2353 14q24.3 human S374-p 448482 PSSDSLSsPTLLAL_ protein stabilization; molecular association, regulation; phosphorylation; enzymatic activity, induced cell cycle regulation; carcinogenesis, induced; cell motility, induced; cell growth, induced; transcription, induced FBXL10(DISRUPTS) 23667255; 26725323; 32075732; 35439648 12 3 0 -G6PD G6PD Carbohydrate Metabolism - pentose phosphate pathway; Cell development/differentiation; EC 1.1.1.49; Other Amino Acids Metabolism - glutathione; Oxidoreductase P11413 2539 Xq28 human K89-ac 11320983 KQSEPFFkATPEEKL G6PD_N protein conformation; enzymatic activity, induced; enzymatic activity, altered 37798264 1 4 0 ubiquitylation of adjacent K95/K97; lowers the thermodynamic stability of G6PD -OPRM1 MOR-1 GPCR, family 1; Membrane protein, integral; Membrane protein, multi-pass; Receptor, GPCR P35372 4988 6q25.2 human T396-p 448128 LENLEAEtAPLP___ receptor desensitization, inhibited 24304623 5 0 0 DAMGO-induced desensitization -CERS6 LASS6 DNA-binding; Membrane protein, integral; Membrane protein, multi-pass Q6ZMG9 253782 2q24.3 human S341-p 40511820 KVSKDDRsDIESSSD enzymatic activity, induced 26887952 1 1 0 -DVL2 DVL2 Adaptor/scaffold; Motility/polarity/chemotaxis O14641 1856 17p13.1 human T595-p 27623903 GSRSSGStRSDGGAG Dsh_C cytoskeletal reorganization; transcription, inhibited 23396967 1 0 0 neurite outgrowth -Map3k7 TAK1 EC 2.7.11.25; KINASE; Kinase, protein; Protein kinase, Ser/Thr (non-receptor); Protein kinase, TKL P0C8E4 313121 5q21 rat T187-p 454704 CDIQTHMtNNKGSAA PK_Tyr_Ser-Thr enzymatic activity, induced cell cycle regulation; autophagy, induced; cell motility, induced; cell growth, induced 35078016 33 1 0 -Cbx5 HP1 alpha Transcription, coactivator/corepressor Q61686 12419 15|15 F3 mouse S11-p 476162 KTKRTADsSSSEDEE molecular association, regulation H3(INDUCES) DNA(INDUCES) 21245376 1 26 2 important for chromosomal stability -HSP90AB1 HSP90B Chaperone; Heat shock protein P08238 3326 6p21.1 human S718-p 3177650 LEGDEDAsRMEEVD_ protein stabilization; molecular association, regulation carcinogenesis, induced; cell growth, induced HOPX(INDUCES); CHIP(DISRUPTS) 22824801 3 9 0 cell proliferation increased -BCL10 Bcl-10 Apoptosis; Transcription, coactivator/corepressor; Tumor suppressor O95999 8915 1p22.3 human S138-p 470125 NNLSRSNsDESNFSE activity, induced; phosphorylation cell motility, altered; cytoskeletal reorganization; signaling pathway regulation; transcription, altered 17371994; 20466000; 21199863; 21674474; 21700900 7 30 18 PPP3CA-regulated NF-kB activation pathway -Cd79a Ig-alpha Immunoglobulin superfamily; Membrane protein, integral P11911 12518 7 A3|7 13.49 cM mouse Y176-p 447751 GVDMPDDyEDENLYE molecular association, regulation; intracellular localization GRB2(INDUCES); BLNK(INDUCES); VAV1(INDUCES) 11859098 6 2 4 -RUNX1 AML1 DNA-binding; Oncoprotein; Transcription factor Q01196 861 21q22.12 human K24-ub 15384407 STALSPGkMSEALPL protein degradation; intracellular localization carcinogenesis, inhibited; cell growth, inhibited; transcription, inhibited 28536267 1 3 1 -XKR5 XKR5 Membrane protein, integral; Membrane protein, multi-pass Q6UX68 389610 8p23.1 human Y543-p 1172732403 GQQSSTLyFSATAEV phosphorylation carcinogenesis, inhibited; cell growth, inhibited; signaling pathway regulation 29910466 1 1 0 inhibits phosphorylation of ERK, AKT and p38 -G3BP1 G3BP-1 Adaptor/scaffold; EC 3.6.4.12; EC 3.6.4.13; Helicase; RNA-binding Q13283 10146 5q33.1 human R460-m1 476717 KPGFGVGrGLAPRQ_ translation, altered 27601476 1 7 72 inhibits Stress Granules (SGs)-RNA granule assembly upon environmental stress -NF2 Merlin Cytoskeletal; Motility/polarity/chemotaxis; Tumor suppressor P35240 4771 22q12.2 human K364-ub 27197394 ERRLLQMkEEATMAN ERM_helical molecular association, regulation; intracellular localization LATS1(DISRUPTS) 30918126 1 4 0 K63 kinked -H3C1 H3 DNA-binding P68431 8350 6p22.2 human K36-m3 1458608 APATGGVkKPHRYRP Histone protein degradation; molecular association, regulation; acetylation; intracellular localization cell cycle regulation; DNA repair, induced; chromatin organization, altered; transcription, induced; transcription, inhibited; transcription, altered MSH6(INDUCES); PHF1(INDUCES); WHSC1(INDUCES); NSD1(INDUCES); PALB2(INDUCES); MORF4L1(INDUCES); N-PAC(INDUCES) DNA(INDUCES) 16732292; 18923077; 19021773; 19521516; 19935671; 20093418; 20139424; 20850016; 23273982; 26602815; 27476967; 28648780; 28663576; 28673974; 28753426 65 11 4 -Appl1 APPL Adaptor/scaffold; Nuclear receptor co-regulator Q8K3H0 72993 14|14 A3 mouse S401-p 449251 ALEAVTPsPSFQQRH molecular association, regulation; phosphorylation signaling pathway regulation IRS2(DISRUPTS); INSR(INDUCES); IRS1(DISRUPTS) 24813896 2 42 0 regulates phosphorylation IRS1/2, AKT and GSK3B, promotes insulin signaling, PI3K signaling pathway -FOXO1 FOXO1A DNA-binding; Nuclear receptor co-regulator; Oncoprotein; Transcription factor Q12778 2308 13q14.11 human S218-p 4258805 NSIRHNLsLHSKFIR Forkhead molecular association, regulation DNA(DISRUPTS) 18786403 1 2 0 -VHL VHL Tumor suppressor; UBIQUITIN LIGASE; Ubiquitin ligase P40337 7428 3p25.3 human S72-p 469117 SVNSREPsQVIFCNR VHL molecular association, regulation cell cycle regulation; carcinogenesis, induced; cytoskeletal reorganization HIF2A(DISRUPTS) 16847331; 23785518 3 1 0 -CDC14A CDC14A EC 3.1.3.16; EC 3.1.3.48; Motility/polarity/chemotaxis; PHOSPHATASE; Protein phosphatase, dual-specificity Q9UNH5 8556 1p21.2 human S411-p 25733761 SQRQPRTsPSCAFRS molecular association, regulation 30089874 1 1 1 interaction with putative unknown substrates or regulators -IRF7 IRF7 DNA-binding; Transcription factor Q92985 3665 11p15.5 human S477-p 1276101 VSSLDSSsLSLCLSS activity, induced; molecular association, regulation; intracellular localization; protein conformation transcription, induced H4(DISRUPTS) 10893229; 25225665 5 0 0 -KLF13 KLF13 C2H2-type zinc finger protein; DNA-binding Q9Y2Y9 51621 15q13.3 human K226-ac 460602 RTHTGEKkFSCPICE molecular association, regulation transcription, induced DNA(DISRUPTS) 12758070 1 0 0 -MCM7 MCM7 DNA replication; EC 3.6.4.12; Motility/polarity/chemotaxis P33993 4176 7q22.1 human K449-m1 58123402 CCIDEFDkMAEADRT MCM molecular association, regulation L3MBTL iso4(INDUCES) 23583077 0 1 0 -TERF1 TRF1 DNA-binding P54274 7013 8q21.11 human T371-p 3727647 VSKSQPVtPEKHRAR protein stabilization; molecular association, regulation; intracellular localization; phosphorylation cell cycle regulation; carcinogenesis, induced; DNA repair, induced; chromatin organization, altered; apoptosis, induced H2AX(INDUCES); 53BP1(INDUCES) DNA(INDUCES); DNA(DISRUPTS) 18625707; 21712819; 23997120; 27185864; 36140400 5 6 8 -SIRT3 SIRT3 DEACETYLASE; Deacetylase; EC 3.5.1.-; Mitochondrial Q9NTG7 23410 11p15.5 human Y226-p 1881476100 KGLLLRLyTQNIDGL enzymatic activity, inhibited 34289383 1 0 0 -POLI POLI DNA repair, damage; EC 2.7.7.7; Transferase Q9UNA4 11201 18q21.2 human K513-ub 50771301 TTNFSKEkDINEFPL protein degradation 26370087 1 2 0 -KLF3 KLF3 C2H2-type zinc finger protein; DNA-binding; Transcription factor P57682 51274 4p14 human K198-sm 3617603 PISQKKIkIEPGIEP molecular association, regulation transcription, inhibited 15684403 1 2 0 -TEK TIE2 EC 2.7.10.1; KINASE; Kinase, protein; Membrane protein, integral; Protein kinase, TK; Protein kinase, tyrosine (receptor) Q02763 7010 9p21.2 human Y992-p 448373 LSRGQEVyVKKTMGR PK_Tyr_Ser-Thr activity, induced; protein conformation 25320242; 28396439 7 0 0 -CHEK1 Chk1 EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, CAMK; Protein kinase, Ser/Thr (non-receptor); Tumor suppressor O14757 1111 11q24.2 human T378-p 1388511401 QRLVKRMtRFFTKLD protein degradation; enzymatic activity, induced cell cycle regulation 30510197 1 0 0 -Cttn Cortactin Actin-binding; Cytoskeletal; Motility/polarity/chemotaxis NP_001385572 60465 1q41-q42 rat Y466-p 447703 AYTSEPVyETTEVPG cell adhesion, altered 15383621 32 3 10 -Exoc8 EXOC8 Vesicle O54924 245709 19q12 rat S93-p 182950101 LLTEQKSsLESIPLA Vps51 molecular association, regulation exocytosis, inhibited Sec5(DISRUPTS); EXOC8(DISRUPTS) 28325821 1 1 0 -HSF1 HSF1 DNA-binding; Transcription factor Q00613 3297 8q24.3 human T527-p 1876167504 PPKAKDPtVS_____ Vert_HS_TF activity, induced; molecular association, regulation transcription, induced CDK9(INDUCES); GTF2B(INDUCES) 35080342 1 1 0 -YWHAZ 14-3-3 zeta Adaptor/scaffold; Motility/polarity/chemotaxis P63104 7534 8q22.3 human S64-p 10407031 SSWRVVSsIEQKTEG 14-3-3 activity, induced; molecular association, regulation; intracellular localization transcription, induced AR(INDUCES) DNA(INDUCES) 34697370 1 6 1 -KCNMA1 KCNMA1 Channel, potassium; Endoplasmic reticulum; Membrane protein, integral; Membrane protein, multi-pass Q28204 282573 cow S695-p 456596 DEQPSTLsPKKKQRN activity, inhibited 20385812 1 20 0 -H3C1 H3 DNA-binding P68431 8350 6p22.2 human K4-ac 10306116 ____ARTkQTARKST Histone cell cycle regulation; carcinogenesis, induced; carcinogenesis, inhibited; apoptosis, induced; transcription, induced; signaling pathway regulation 20546607; 26783963; 28068431 16 2 9 CIL-102 activation of the JNK1/2 pathway and p300/CBP acetylation of H3K4 -Gorasp2 GRASP55 Motility/polarity/chemotaxis; Vesicle Q9R064 113961 3q22 rat S245-p 12654012 SVSPPSLsPPGTAGV molecular association, regulation cytoskeletal reorganization GRASP55(DISRUPTS) 20083603 1 0 5 inhibits Golgi stack formation in interphase cells and enhances Golgi fragmentation in mitotic cells -Cacng2 Stargazin Channel, calcium; Membrane protein, integral; Membrane protein, multi-pass Q71RJ2 84347 7q34 rat S253-p 455307 PSHSRDAsPVGVKGF molecular association, regulation neural plasticity PSD-95(INDUCES) 25843401 3 7 0 -Plekhg5 PLEKHG5 Q66T02 269608 4|4 E2 mouse S92-p 27528601 SVLARNVsTRSCPPR molecular association, regulation; intracellular localization; enzymatic activity, inhibited cytoskeletal reorganization; cell adhesion, inhibited 14-3-3 beta(INDUCES); RHOA(DISRUPTS); 14-3-3 zeta(INDUCES); 14-3-3 epsilon(INDUCES); 14-3-3 gamma(INDUCES) 23335514 1 2 0 inhibits targeting to cell border -MYC Myc DNA-binding; Nucleolus; Oncoprotein; Transcription factor P01106 4609 8q24.21 human T373-p 450960 EENVKRRtHNVLERQ HLH molecular association, regulation carcinogenesis, inhibited; cell differentiation, induced; transcription, induced MAX(DISRUPTS) DNA(INDUCES); DNA(DISRUPTS) 22020439; 26678338 6 0 0 repression of YAP/TAZ activity -ARID4A RbBP1 Adaptor/scaffold P29374 5926 14q23.1 human S864-p 14578923 RKILGQSsPEKKIRI molecular association, regulation Rb(DISRUPTS) 21148318 1 31 0 -PRMT5 PRMT5 Cell cycle regulation; EC 2.1.1.125; METHYLTRANSFERASE; Methyltransferase; Methyltransferase, protein arginine; RNA processing O14744 10419 14q11.2 human T80-p 62906108 LSGRDWNtLIVGKLS PRMT5_TIM methylation; enzymatic activity, induced 28074910; 36232624 2 0 0 induces H4 methylation -KCNN4 KCNN4 Channel, potassium; Membrane protein, integral; Membrane protein, multi-pass O15554 3783 19q13.31 human S334-p 452145 KHTRRKEsHAARRHQ CaMBD activity, inhibited Calmodulin(DISRUPTS) 25274816 3 0 0 inhibits channel current, inhibits Ca++ influx -RNF20 RNF20 EC 6.3.2.-; EC 6.3.2.19; Ligase; UBIQUITIN LIGASE; Ubiquitin conjugating system; Ubiquitin ligase Q5VTR2 56254 9q31.1 human S553-p 482125 QSSASKAsQEDANEI ubiquitination DNA repair, induced 21362549 1 2 0 induces H2B-K125 ubiquitylation -CDT1 CDT1 DNA replication; DNA-binding; Motility/polarity/chemotaxis; Oncoprotein Q9H211 81620 16q24.3 human S391-p 20804632 LRSAAPSsPGSPRPA protein stabilization; molecular association, regulation; activity, inhibited RAMP(DISRUPTS) 21930785 2 5 1 -Mapt Tau ACETYLTRANSFERASE; Acetyltransferase; Cytoskeletal P19332 29477 10q32.1 rat S519-p 487449 GSPGTPGsRSRTPSL molecular association, regulation 28784767 4 7 5 aggregation -ETV5 ERM DNA-binding; Transcription factor P41161 2119 3q27.2 human K293-sm 2887209 FQSPMGIkQEPRDYC ETS_PEA3_N transcription, inhibited 15857832; 18243147 2 0 0 -FTH1 Ferritin-H Cofactor and Vitamin Metabolism - porphyrin and chlorophyll; EC 1.16.3.1; Oxidoreductase P02794 2495 11q12.3 human S179-p 452608 DKHTLGDsDNES___ molecular association, regulation; intracellular localization; phosphorylation cell motility, altered CXCR4(INDUCES) 17056593 1 31 4 overexpression of S179A Ferritin-H increases them.; Overexpression of Ferritin-H reduces phospho-Erk1/2 levels -Thra TR-alpha DNA-binding; Nuclear receptor; Transcription factor P63058 21833 11 D|11 62.58 cM mouse K283-sm 27490404 LSGEMAVkREQLKNG Hormone_recep intracellular localization cell cycle regulation; cell growth, induced; transcription, induced DNA(INDUCES) 34916557 4 0 0 mutant mice had reduced fat stores on normal chow, and was reduced, more on high fat diets ; reduced CREB and AP1-mediated gene expression, reduced TR-alpha?CREB interaction in mutant preadipocytes; decreased preadipocyte proliferation, reduced white adipose stores and adipocyte cell diameter in mutant mice; (K283Q/K288R)-/- mutant: reduced nuclear localization of cyclin D1, cyclin D2, Cdk4 and Cdk2 in human primary preadipocytes -Tp63 p63 DNA-binding; Transcription factor O88898 22061 16 B1|16 17.37 cM mouse S162-p 451601 TFDALSPsPAIPSNT apoptosis, induced; signaling pathway regulation 29988075 6 2 0 -CENPQ CENPQ Q7L2Z9 55166 6p12.3 human S253-p 23092802 HNSSQMKsMSTFIEE CENP-Q molecular association, regulation; intracellular localization DNA(DISRUPTS) 25670858 1 1 1 CENPQ phosphorylation promotes the delocalization of the PBIP1-CENPQ complex from kinetochores -CDC25C CDC25C EC 3.1.3.48; Motility/polarity/chemotaxis; PHOSPHATASE; Protein phosphatase, dual-specificity P30307 995 5q31.2 human S122-p 449910 DQHLMKCsPAQLLCS cell cycle regulation; cell adhesion, altered 8119945 1 3 5 -FLNB FLNB Actin-binding; Motility/polarity/chemotaxis O75369 2317 3p14.3 human K681-ub 22244658 DAGKAPLkIFAQDGE Filamin protein degradation 26676607 0 3 0 -RNF11 RNF11 EC 6.3.2.-; Ligase; UBIQUITIN LIGASE; Ubiquitin conjugating system; Ubiquitin ligase Q9Y3C5 26994 1p32.3 human T135-p 2893400 DWLMRSFtCPSCMEP zf-RING_2 protein degradation; molecular association, regulation transcription, altered 14-3-3 gamma(INDUCES) 16123141 1 0 0 -Hnrnpf hnRNP F RNA splicing; RNA-binding; Spliceosome Q794E4 64200 4q42 rat K98-ac 15294655 TEMDWVLkHSGPNSA protein stabilization RNA splicing, induced 25959059 1 3 1 -DYNC1I2 DYNC1I2 iso3 Microtubule-binding; Motility/polarity/chemotaxis; Motor Q13409-3 1781 2q31.1 human S84-p 4033130 PPPMSPSsKSVSTPS cell motility, inhibited 24798412 3 11 2 S84D mutant retrograde movement was more likely compared to S84A mutant -ERCC3 XPB DNA repair, damage; EC 3.6.4.12; Helicase; Transcription factor P19447 2071 2q14.3 human S751-p 454425 FGTMSSMsGADDTVY activity, inhibited 15549133 2 0 0 -ARAP1 CENTD2 GAP; GAP, ARF; Motility/polarity/chemotaxis Q96P48 116985 11q13.4 human Y231-p 3209592 PEFDDSDyDEVPEEG endocytosis, altered 20554524 1 6 57 inhibits EGFR internalization -Lepr LEPR Membrane protein, integral; Receptor, cytokine P48356 16847 4 C6|4 46.96 cM mouse Y985-p 448435 QRQPSVKyATLVSND activity, induced; molecular association, regulation; activity, inhibited; phosphorylation signaling pathway regulation; transcription, altered SOCS3(INDUCES); SHP-2(INDUCES) 10449753; 10799542; 11018044; 11085989; 11108838; 15634336; 20059770; 20086094; 32348667 16 0 0 energy metabolism; attenuation of STAT3 phosphorylation; induces leptin signaling; leptin signaling -USP4 USP4 DEUBIQUITINASE; EC 3.4.19.12; Oncoprotein; Protease; Ubiquitin conjugating system; Ubiquitin-specific protease Q13107 7375 3p21.31 human S445-p 5204831 NHRLRNDsVIVDTFH UCH protein stabilization; molecular association, regulation; intracellular localization; enzymatic activity, induced signaling pathway regulation 14-3-3 sigma(INDUCES); 14-3-3 zeta(DISRUPTS); 14-3-3 eta(INDUCES) 22706160 1 3 1 -GAREM1 GAREM Adaptor/scaffold Q9H706 64762 18q12.1 human Y105-p 9721500 DIKEPVQyFNSVEEV CABIT molecular association, regulation GRB2(INDUCES) 19509291 1 0 0 activates Erk -SNIP1 SNIP1 Inhibitor Q8TAD8 79753 1p34.3 human K5-sm 59149203 ___MKAVkSERERGS molecular association, regulation cell motility, induced; transcription, induced 27703003 1 0 0 SUMOylation decreases the inhibitory effect of SNIP1 on TGF-beta-induced formation of the Smad2/4 and Smad3/4 complexes -Ncoa3 SRC-3 ACETYLTRANSFERASE; Acetyltransferase; EC 2.3.1.48; Motility/polarity/chemotaxis; Nuclear receptor co-regulator; Transcription, coactivator/corepressor O09000 17979 2|2 H3 mouse R1195-m2 2363404 QQFLNQSrQALEMKM protein degradation transcription, inhibited CBP(INDUCES) 17043108 1 1 19 -TP53 p53 Activator; DNA-binding; Motility/polarity/chemotaxis; Nuclear receptor co-regulator; Transcription factor; Tumor suppressor P04637 7157 17p13.1 human S376-p 447570 LKSKKGQsTSRHKKL activity, induced; protein degradation; molecular association, regulation; intracellular localization; activity, inhibited cell cycle regulation; apoptosis, induced; chromatin organization, altered; apoptosis, inhibited; transcription, induced S100B(DISRUPTS); 14-3-3 zeta(DISRUPTS); 14-3-3 gamma(INDUCES); BLM(DISRUPTS); S100A2(DISRUPTS); 14-3-3 beta(DISRUPTS); WRN(DISRUPTS) DNA(INDUCES) 11007451; 11585729; 12080066; 14744935; 16227590; 17898864; 19819244; 34798143; 9315650; 9620776 13 0 0 arsenic induced overexpression of PUMA, P53 phosphorylation and acetylation, activation and accumulation of p53, PUMA disruption of Bcl-X complexes with pro-survival proteins resulting in apoptosis -RPS6KA1 p90RSK EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, AGC; Protein kinase, Ser/Thr (non-receptor); Translation P18652 386579 chicken S381-p 447989 TSRTPKDsPGIPPSA Pkinase_C intracellular localization; enzymatic activity, induced 11585927 42 47 4 -MAPK7 ERK5 EC 2.7.11.24; KINASE; Kinase, protein; Protein kinase, CMGC; Protein kinase, Ser/Thr (non-receptor) Q13164 5598 17p11.2 human T219-p 448205 AEHQYFMtEYVATRW Pkinase cell cycle regulation; carcinogenesis, induced; cell motility, induced; apoptosis, inhibited; transcription, induced 20138986; 31980741; 34655447 20 2 31 -CTNND1 CTNND1 Actin-binding; Adaptor/scaffold; Cell adhesion; G protein regulator, misc.; Motility/polarity/chemotaxis O60716 1500 11q12.1 human Y335-p 454928 EVPSDQYyWAPLAQH molecular association, regulation; intracellular localization CDH1(DISRUPTS) 35030104 1 9 132 -ESR1 ER-alpha DNA-binding; Nuclear receptor; Transcription factor P03372 2099 6q25.1-q25.2 human S236-p 448739 IDKNRRKsCQACRLR zf-C4 transcription, inhibited 22266331; 9891036 5 1 0 -IRS1 IRS1 Adaptor/scaffold; Motility/polarity/chemotaxis P35568 3667 2q36.3 human Y662-p 450356 QRVDPNGyMMMSPSG molecular association, regulation cell differentiation, induced; transcription, induced PIK3R1(INDUCES) 12525499 2 5 90 -Hspb1 HSP27 Chaperone; Heat shock protein; Motility/polarity/chemotaxis; SUMO LIGASE; SUMO ligase P14602 15507 5 G2|5 75.51 cM mouse S15-p 448401 FSLLRSPsWEPFRDW activity, induced; intracellular localization apoptosis, induced PKCD(NOT_REPORTED) 15731106 52 78 30 -CRYAB CRYAB Chaperone; Heat shock protein P02511 1410 11q23.1 human K92-ac 459002 SPEELKVkVLGDVIE HSP20 activity, induced; protein stabilization; molecular association, regulation; protein conformation; activity, inhibited apoptosis, inhibited CRYGA(INDUCES) 23508955; 24128140 1 7 0 Induces MDH activity; higher a?nity for denatured proteins -GDI2 GDI2 G protein regulator, misc.; Motility/polarity/chemotaxis P50395 2665 10p15.1 human S382-p 5829589 PIEQKFVsISDLLVP GDI molecular association, regulation RAB5A(INDUCES); RAB11A(INDUCES) 33914026 1 1 9 -ARHGAP24 ARHGAP24 GAP; GAP, Rac/Rho; Motility/polarity/chemotaxis Q8N264 83478 4q21.23-q21.3 human T452-p 12518705 GLEKTQTtPNGSLQA activity, induced cytoskeletal reorganization 16862148 1 1 2 membrane blebbing -Syk Syk EC 2.7.10.2; KINASE; Kinase, protein; Protein kinase, TK; Protein kinase, tyrosine (non-receptor) P48025 20963 13 A5|13 27.41 cM mouse Y290-p 448709 IISRIKSySFPKPGH intracellular localization 20956537 3 11 95 -MAFG MAFG Cell cycle regulation; DNA-binding O15525 4097 17q25.3 human K53-ac 458964 KEEIVQLkQRRRTLK bZIP_Maf molecular association, regulation DNA(INDUCES) 11154691 1 0 0 -Cdh2 CDH2 Cell adhesion; Membrane protein, integral; Motility/polarity/chemotaxis Q9Z1Y3 83501 18p13 rat S871-p 382737700 GSTAGSLsSLNSSSS CADH_Y-type_LIR intracellular localization cytoskeletal reorganization CTNNB1(INDUCES) 29133434 1 0 0 PKD1 colocalizes with N-cadherin at dendritic spines mainly in the postsynaptic compartment, long-term potentiation (LTP) induction and regulates synaptic plasticity -TUBB4B TUBB2C Cytoskeletal; Motility/polarity/chemotaxis P68371 10383 9q34.3 human K19-m1 58123405 CGNQIGAkFWEVISD Tubulin molecular association, regulation L3MBTL iso4(INDUCES) 23583077 0 1 0 -ATF6 ATF6A Membrane protein, integral; Transcription factor P18850 22926 1q23.3 human S104-p 35527101 SSSYSVSsPRSVDSY transcription, induced 25135476 1 0 0 -RAPGEF2 RAPGEF2 GEF; GEF, Ras; Motility/polarity/chemotaxis Q9Y4G8 9693 4q32.1 human S1254-p 30995202 GSWTSCSsGSHDNIQ phosphorylation 24290981 1 1 0 Phosphorylation at S1254 promotes CK1-alpha dependent phosphorylation at S1244 and S1248 -Mpc2 MPC2 Membrane protein, multi-pass; Mitochondrial Q9D023 70456 1|1 H2.2 mouse K19-ac 467165 TYHRLMDkVELLLPK protein degradation; activity, inhibited 28154187 1 5 2 inhibits pyruvate transport activity -NPFFR2 NPFFR2 GPCR, family 1; Membrane protein, integral; Membrane protein, multi-pass; Receptor, GPCR Q9Y5X5 10886 4q13.3 human T477-p 36533413 KSHVLINtSNQLVQE receptor desensitization, induced 25326382 1 1 0 -PAK6 PAK6 EC 2.7.11.1; KINASE; Kinase, protein; Nuclear receptor co-regulator; Protein kinase, STE; Protein kinase, Ser/Thr (non-receptor) Q9NQU5 56924 15q15.1 human S346-p 29666300 TGQLPGRsSPAGSPR molecular association, regulation; enzymatic activity, induced carcinogenesis, induced; cell motility, induced AR(INDUCES) 24130878 1 2 0 promotion of cell motility and invasion -NQO1 NQO1 EC 1.6.5.2; Oxidoreductase P15559 1728 16q22.1 human T128-p 1868914500 FIGEFAYtYAAMYDK Flavodoxin_2 protein degradation; molecular association, regulation; ubiquitination; enzymatic activity, inhibited; phosphorylation; enzymatic activity, induced apoptosis, induced PARK2(INDUCES) Other(DISRUPTS) 31358653; 36096178 2 1 0 repression of dopaminergic loss observed in S40A/T128A mutatnt; induces AEP activity and synuclein phosphorylation; inhibits FAD binding -Hhex HHEX DNA-binding; Transcription factor F7F7Q9 rat S153-p 7430501 LAKMLQLsERQVKTW Homeodomain cell cycle regulation; cell growth, induced 28927755 2 0 0 neointima formation ex vivo -ATG16L1 ATG16L1 iso3 Adaptor/scaffold; Autophagy; Membrane protein, peripheral Q676U5-3 55054 2q37.1 human S269-p 460725 RAATKRLsQPAGGLL protein degradation autophagy, inhibited 31580256 1 20 12 -FCRL3 FCRL3 Adaptor/scaffold; Membrane protein, integral Q96P31 115352 1q23.1 human Y692-p 469982 HEELTVLySELKKTH molecular association, regulation SHP-1(INDUCES) 12051764 1 0 0 -PDE4D PDE4D iso6 EC 3.1.4.53; Nucleotide Metabolism - purine; Phosphodiesterase Q08499-6 5144 5q11.2-q12.1 human S126-p 458388 VHSQRREsFLYRSDS enzymatic activity, altered; enzymatic activity, induced 23826796; 31209056 10 21 1 -RETREG1 FAM134B Membrane protein, integral; Membrane protein, multi-pass Q9H6L5 54463 5p15.1 human K160-ac 1881577500 SWEVINSkPDERPRL molecular association, regulation; phosphorylation autophagy, induced FAM134B(INDUCES); CAMK2A(INDUCES) 37043189 1 1 0 -TIAM1 TIAM1 GEF; GEF, Rac/Rho; Motility/polarity/chemotaxis; Oncoprotein Q13009 7074 21q22.11 human S695-p 4727713 KRRSRFSsLWGLDTT protein stabilization; molecular association, regulation 14-3-3 beta(INDUCES) 25746002 1 5 23 -Irs1 IRS1 Adaptor/scaffold; Motility/polarity/chemotaxis P35570 25467 9q34 rat S731-p 2352500 TGDYMNMsPVGDSNT enzymatic activity, inhibited 8626671 2 0 0 The serine phosphorylation sites negatively regulate PI3 kinase activity associated with IRS-1. -Camk1 CAMK1A EC 2.7.11.17; KINASE; Kinase, protein; Protein kinase, CAMK; Protein kinase, Ser/Thr (non-receptor) Q91YS8 52163 6 E3|6 52.75 cM mouse T177-p 448527 DPGSVLStACGTPGY Pkinase autophagy, induced; cell growth, induced 35145192 10 6 7 induces mitophagy -FOXO1 FOXO1A DNA-binding; Nuclear receptor co-regulator; Oncoprotein; Transcription factor Q12778 2308 13q14.11 human S383-p 12607402 DNLNLLSsPTSLTVS intracellular localization transcription, altered 20061393 2 0 0 multiple site mutant (8A) -MDC1 MDC1 Cell cycle regulation Q14676 9656 6p21.33 human T331-p 477988 FGFIDSDtDAEEERI molecular association, regulation cell cycle regulation NBS1(INDUCES) 18678890 1 26 27 MDC1-NBS1 interaction regulates intra-S-phase checkpoint activation -NDC80 HEC1 Cell cycle regulation O14777 10403 18p11.32 human S44-p 474539 KPTFGKLsINKPTSE cell cycle regulation; cytoskeletal reorganization 17129782; 32027339; 35878017 9 4 0 -RPTOR Raptor Adaptor/scaffold Q8N122 57521 17q25.3 human S792-p 2314600 DKMRRASsYSSLNSL molecular association, regulation cell cycle regulation; carcinogenesis, inhibited; autophagy, induced; cell growth, inhibited; apoptosis, inhibited; transcription, altered; signaling pathway regulation 4E-BP1(DISRUPTS) 21460630; 21900751; 28778925; 34247189; 34604061; 34820368 36 4 0 -YAP1 YAP1 iso2 Oncoprotein; Transcription, coactivator/corepressor P46937-2 10413 11q22.1 human S94-p 3253276 RLRKLPDsFFKPPEP transcription, induced 19141641 8 3 3 -Prkch PKCH EC 2.7.11.13; KINASE; Kinase, protein; Protein kinase, AGC; Protein kinase, Ser/Thr (non-receptor) P23298 18755 12|12 C3 mouse S32-p 3074800 TRWSLRHsLFKKGHQ C2 molecular association, regulation; intracellular localization cell growth, inhibited CTLA-4(INDUCES) 24705298 2 3 8 -H3F3C H3 DNA-binding P84229 427887 chicken K9-ac 463820 RTKQTARkSTGGKAP Histone transcription, induced 19950192 230 26 341 -Prkcd PKCD EC 2.7.11.13; KINASE; Kinase, protein; Nuclear receptor co-regulator; Protein kinase, AGC; Protein kinase, Ser/Thr (non-receptor); Protein kinase, tyrosine (non-receptor); Tumor suppressor P28867 18753 14 B|14 18.82 cM mouse Y187-p 447579 WGLNKQGyKCRQCNA C1_1 molecular association, regulation; intracellular localization apoptosis, induced; transcription, altered Fyn(INDUCES) 10945993; 11739733 6 0 0 -KDM2A FBXL11 DEMETHYLASE; Demethylase; EC 1.14.11.27; Oxidoreductase Q9Y2K7 22992 11q13.2 human T632-p 482318 EVDQNEEtQDFEKKL PHD_4 molecular association, regulation DNA repair, induced DNA(DISRUPTS) 25823024 1 2 4 -ID3 ID3 DNA-binding; Transcription, coactivator/corepressor Q02535 3399 1p36.12 human S65-p 297110002 VPRGTQLsQVEILQR HLH molecular association, regulation DNA repair, induced MDC1(INDUCES) 29026069 1 0 0 -RBL1 Rb-like 1 Transcription, coactivator/corepressor; Tumor suppressor P28749 5933 20q11.23 human S615-p 36125980 HLPLMPMsPLMHPRV cell cycle regulation 34661528 1 5 0 -FOXM1 FOXM1 DNA-binding; Transcription factor Q08050 2305 12p13.33 human S739-p 18009877 SKILLDIsFPGLDED cell cycle regulation; transcription, induced 19160488 3 1 0 orderly mitotic progression -AQP2 AQP2 Channel, misc.; Membrane protein, integral; Membrane protein, multi-pass; Transporter; Transporter, aquaporin family P41181 359 12q13.12 human S256-p 449854 REVRRRQsVELHSPQ molecular association, regulation; intracellular localization exocytosis, induced HSP70(DISRUPTS); VTA1(DISRUPTS); TIRAP(INDUCES); AQP2(INDUCES) 11067864; 11076974; 12194985; 14519593; 15625084; 16120822; 16303856; 17940053; 18042467; 18664568; 19357255; 22778181; 24700872; 26714855; 28710278; 29145196; 32486031; 32529500 78 9 0 -MELK MELK EC 2.7.10.2; EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, CAMK; Protein kinase, Ser/Thr (non-receptor); Protein kinase, tyrosine (non-receptor); RNA splicing Q14680 9833 9p13.2 human S171-p 2861400 HLQTCCGsLAYAAPE Pkinase enzymatic activity, induced 16216881 2 0 0 -Arhgap31 CdGAP GAP; GAP, Rac/Rho A6X8Z5 12549 16|16 B4 mouse T776-p 456517 TPAPPPPtPLEEEPE activity, inhibited transcription, altered 16024771; 17158447; 20728428 3 0 0 increases CdGAP expression -KIF20A KIF20A Microtubule-binding; Motor O95235 10112 5q31.2 human S7-p 18011282 _MSQGILsPPAGLLS molecular association, regulation; intracellular localization; protein conformation cell cycle regulation INCENP(DISRUPTS) 24656812 1 4 0 favours solubility, inhibits microtubule binding -NCL NCL DNA-binding; Helicase; Nuclear receptor co-regulator; Nucleolus; RNA-binding P19338 4691 2q37.1 human S184-p 466006 AAAAAPAsEDEDDED intracellular localization cell cycle regulation; cell growth, induced 25313645 2 27 28 -TARDBP TDP-43 RNA-binding Q13148 23435 1p36.22 human K95-ub 15398515 TDASSAVkVKRAVQK protein degradation 32175624 1 7 6 -HIC1 HIC1 C2H2-type zinc finger protein; Transcription factor; Tumor suppressor Q14526 3090 17p13.3 human K333-ac 1910103 SLLYRWMkHEPGLGS molecular association, regulation transcription, induced; transcription, inhibited TAT(DISRUPTS); MTA1(DISRUPTS) 17283066; 20547755; 27725726 3 0 0 impaired-expression of the HIV-1 -KDM5A JARID1A DEMETHYLASE; Demethylase; EC 1.14.11.-; Nuclear receptor co-regulator; Nucleolus; Oxidoreductase; Transcription factor P29375 5927 12p13.33 human S1255-p 56630502 CLTERAMsWQDRARQ intracellular localization 27292631 1 0 0 JARID1A recruitment to the promoters of AKT-regulated genes -MAPT Tau iso8 ACETYLTRANSFERASE; Acetyltransferase; Cytoskeletal P10636-8 4137 17q21.31 human K174-ub 1873595600 NATRIPAkTPPAPKT protein degradation autophagy, induced 28972160 1 0 0 -GATA2 GATA2 Transcription factor P23769 2624 3q21.3 human S401-p 455583 QTRNRKMsNKSKKSK molecular association, regulation; intracellular localization; activity, inhibited cell growth, induced; cell differentiation, induced; transcription, induced; transcription, altered; cell growth, altered FOG1(INDUCES) 15837948; 35172146 2 0 5 -cdkn1a p21Cip1 Cell cycle regulation; Inhibitor Q683K8 dog S91-p 4943330 TCTLLPHsPERPEAS protein stabilization cell cycle regulation 22908227 2 0 0 -PROX1 PROX1 DNA-binding; Nuclear receptor co-regulator; Transcription factor Q92786 5629 1q32.3 human K353-sm 6124706 KHLAETLkQELNTAM molecular association, regulation; intracellular localization transcription, induced HDAC3(DISRUPTS) 18948102 1 0 0 Sumoylation downregulates the corepressor activity of Prox1 and reduces its recruitment of HDAC3. -Hnrnpf hnRNP F RNA splicing; RNA-binding; Spliceosome Q794E4 64200 4q42 rat K98-ub 15390280 TEMDWVLkHSGPNSA protein stabilization RNA splicing, induced 25959059 1 8 3 -TSC2 TSC2 Cell cycle regulation; GAP; GAP, misc.; Nuclear receptor co-regulator; Tumor suppressor P49815 7249 16p13.3 human S932-p 4728973 DDTPEKDsFRARSTS activity, inhibited signaling pathway regulation 30684133 1 2 5 mTORC1 activation and signaling -Creb1 CREB DNA-binding; Transcription factor Q01147 12912 1 C2|1 32.74 cM mouse K122-ac 459099 SRRPSYRkILNDLSS pKID activity, induced; molecular association, regulation transcription, induced SIRT1(INDUCES) 22078933; 26804914 4 0 0 Lys136 acetylation increases Creb sensitivity to PKA-dependent phosphorylation, K136Q mutant creb reverses the phenotype of WTD-fed SirBACO mice; enhanced by CBP, glucose sensing and regulate Hes-1 transcription -HSD3B2 HSD3B2 EC 1.1.1.145; EC 5.3.3.1; Endoplasmic reticulum; Isomerase; Lipid Metabolism - C21-steroid hormone; Lipid Metabolism - androgen and estrogen; Membrane protein, integral; Mitochondrial; Oxidoreductase P26439 3284 1p12 human S95-p 1410340101 FGVTHREsIMNVNVK 3Beta_HSD enzymatic activity, altered 30580688 1 1 0 Regulate steroidogenic enzyme activity -LOC100399755 GNRHR2 GPCR, family 1; Membrane protein, integral; Membrane protein, multi-pass; Receptor, GPCR Q95MG6 100399755 marmoset S339-p 454394 QELSMDSsREEGSRR receptor internalization, altered 15205374 1 0 0 -PKMYT1 Myt1 EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, Other; Protein kinase, Ser/Thr (non-receptor); Protein kinase, dual-specificity (non-receptor) Q99640 9088 16p13.3 human T461-p 11331002 STPRSRCtPRDALDL molecular association, regulation PIN1(INDUCES) 10504341 1 0 0 -Bmal1 BMAL1 DNA-binding; Transcription factor Q9WTL8 11865 7 F1|7 59.17 cM mouse K266-sm 3055600 KCNRPSVkVEDKDFA protein degradation transcription, induced 16109848 2 1 0 regulation of circadian clock -TRAF3 TRAF3 UBIQUITIN LIGASE; Ubiquitin conjugating system; Ubiquitin ligase Q13114 7187 14q32.32 human Y116-p 1869973805 EILALQIyCRNESRG ubiquitination 32779804 1 0 0 -ARHGEF7 ARHGEF7 iso1 GEF; GEF, Rac/Rho; Motility/polarity/chemotaxis Q14155-1 8874 13q34 human S516-p 455215 RKPERKPsDEEFASR RhoGEF67_u2 molecular association, regulation cytoskeletal reorganization KCC2(INDUCES) 26056138 4 54 30 increased increase number of dendritic spines and synapses -AKT3 Akt3 EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, AGC; Protein kinase, Ser/Thr (non-receptor) Q9Y243 10000 1q43-q44 human S472-p 447937 RPHFPQFsYSASGRE Pkinase_C phosphorylation carcinogenesis, induced; cell growth, induced; cell motility, altered 26523971; 36476861 10 9 20 induces TSC2 phosphorylation; neuronal development migration defects -Dab1 DAB1 iso2 Adaptor/scaffold P97318-2 13131 4 C6|4 47.79 cM mouse T470-p 479418 DISQLNLtPVTSTTP phosphorylation 16529723 1 0 0 inhibits tyrosine phosphorylation -Wasl N-WASP Adaptor/scaffold; Motility/polarity/chemotaxis O08816 682507 4q22 rat T259-p 23003804 IYDFIEKtGGVEAVK molecular association, regulation; protein conformation cytoskeletal reorganization 22250195 1 0 0 inhibits actin polymerization in vitro; inhibits the filopodia promoting activity of N-WASP -TRAF3 TRAF3 UBIQUITIN LIGASE; Ubiquitin conjugating system; Ubiquitin ligase Q13114 7187 14q32.32 human K436-ub 1877126905 KQEAVMGkTLSLYSQ molecular association, regulation; intracellular localization transcription, altered MAVS(INDUCES); TBK1(INDUCES) 32324863 1 1 0 TRIM24-mediated antiviral immunity, VSV-induced interaction of TRAF3 with MAVS and TBK1 -PHGDH PHGDH Amino Acid Metabolism - glycine, serine and threonine; Cell development/differentiation; EC 1.1.1.95; Oxidoreductase O43175 26227 1p12 human T78-p 4730715 QVVGRAGtGVDNVDL 2-Hacid_dh carcinogenesis, induced; cell growth, induced; apoptosis, inhibited 23374352 1 19 1 -TGFBR1 TGFBR1 EC 2.7.11.30; KINASE; Kinase, protein; Membrane protein, integral; Protein kinase, Ser/Thr (receptor); Protein kinase, TKL; Receptor, misc. P36897 7046 9q22.33 human K178-ub 38557705 ISEGTTLkDLIYDMT TGF_beta_GS intracellular localization cell cycle regulation; carcinogenesis, induced; transcription, induced 25622187 1 0 0 tumor cell invasion by inducing genes T?RI, Snail1, and matrix metallopeptidase 2 (MMP2) -RB1 Rb Nuclear receptor co-regulator; Oncoprotein; Transcription, coactivator/corepressor; Tumor suppressor P06400 5925 13q14.2 human T841-p 14160965 SIGESFGtSEKFQKI Rb_C molecular association, regulation cell cycle regulation; chromatin organization, altered; signaling pathway regulation E2F2(INDUCES); E2F1(INDUCES) DNA(DISRUPTS) 33219128 1 6 10 TCR signaling -STRAP STRAP Adaptor/scaffold; RNA splicing; UBIQUITIN LIGASE; Ubiquitin ligase Q9Y3F4 11171 12p12.3 human K147-ac 1876755700 SGHTSGIkKALWCSE WD40 protein stabilization transcription, induced 32527012 1 0 0 upregulation and stabilization of p53 as well as its targets -ELMO1 ELMO1 Cytoskeletal; Motility/polarity/chemotaxis Q92556 9844 7p14.2-p14.1 human Y18-p 455871 AIEWPGAyPKLMEID molecular association, regulation; intracellular localization NCK1(INDUCES); RHOG(INDUCES) 24928514 3 2 45 Nck1 enhances ELMO1 and RhoG interaction and promotes Rac1 activity; localization of ELMO1 to the plasma membrane -TAB1 TAB1 Activator; Motility/polarity/chemotaxis Q15750 10454 22q13.1 human S452-p 22869801 STNTHTQsSSSSSDG intracellular localization; phosphorylation; enzymatic activity, induced transcription, inhibited 22216226 1 0 0 TAB1 induce p38 MAPK phosphorylation and mRNA destabilization, induces p38 MAPK activation. TAB1 and p38MAPK mutually control eachother's phosphorylation status, activity and intracellular localization. -Slc12a3 NCCT Membrane protein, integral; Membrane protein, multi-pass; Transporter; Transporter, SLC family P55018 54300 19p13-p12 rat S71-p 469631 AYEHYANsALPGEPR AA_permease_N ubiquitination; receptor internalization, inhibited 24668812 15 2 1 ubiquitination reduced -KDM3A JMJD1A DEMETHYLASE; Demethylase; EC 1.14.11.-; Nuclear receptor co-regulator; Oxidoreductase Q9Y4C1 55818 2p11.2 human Y1101-p 462537 PDLGPKMyNAYGLIT methylation; enzymatic activity, induced carcinogenesis, induced; cell motility, induced; cell growth, induced; transcription, induced 30377265 1 1 1 induces H3 demethylation -Gpnmb GPNMB Membrane protein, integral Q99P91 93695 6 B2.3|6 23.82 cM mouse S546-p 12738565 TVKGKGLsVLLSHAK carcinogenesis, induced; cell motility, induced; cell growth, induced; transcription, altered 34327762 1 6 0 -AP2B1 AP2B1 Vesicle P63010 163 17q12 human Y737-p 450538 THRQGHIyMEMNFTN Alpha_adaptinC2 molecular association, regulation ARRB1(DISRUPTS); AGTRAP(DISRUPTS) 17456551 2 5 9 -CRTC2 TORC2 Transcription, coactivator/corepressor Q53ET0 200186 1q21.3 human S238-p 1870757301 DAKKLSSsSSRPRSC TORC_M molecular association, regulation; intracellular localization; phosphorylation carcinogenesis, induced; cell motility, induced; cell growth, induced; transcription, induced CREB(INDUCES) 33000695 1 0 0 inhibits phosphorylation at S171 -MAP2K1 MEK1 EC 2.7.12.2; KINASE; Kinase, protein; Protein kinase, STE; Protein kinase, dual-specificity (non-receptor) Q02750 5604 15q22.31 human T292-p 448287 ETPPRPRtPGRPLSS Pkinase molecular association, regulation; enzymatic activity, inhibited; phosphorylation carcinogenesis, induced; transcription, induced; signaling pathway regulation ERK2(INDUCES); ERK1(DISRUPTS); RAF1(INDUCES) 10567369; 14993270; 25971971; 33789117; 8114697; 9351825 14 6 0 induces ERK pathway; inhibits ERK mediated phosphorylation at T286 and ERK phosphorylation, regulates Ras/MEK/ERK signaling -Raet1e RAET1E Membrane protein, integral Q9CZQ6 379043 10|10 A3 mouse K80-ac 1877559401 MTSGDPGkMANATGK MHC_I_2 protein stabilization 33279621 1 0 0 protects RAET1E from shedding; induces antitumor immunity -SRC Src EC 2.7.10.2; KINASE; Kinase, protein; Oncoprotein; Protein kinase, TK; Protein kinase, tyrosine (non-receptor) P12931 6714 20q11.23 human K298-ub 1877830400 GTTRVAIkTLKPGTM ubiquitination; enzymatic activity, induced 31619538 2 0 0 -LPIN1 LPIN1 EC 3.1.3.4; Phosphatase, lipid Q14693 23175 2p25.1 human Y413-p 1871177711 DPEVAALyFPKNGDP enzymatic activity, induced carcinogenesis, induced; cell growth, induced 33203880 1 1 0 Activity of PAP, increase glycolipid synthesis -TTK TTK Cancer Testis Antigen (CTA); EC 2.7.12.1; KINASE; Kinase, protein; Protein kinase, Other; Protein kinase, dual-specificity (non-receptor) P33981 7272 6q14.1 human S291-p 31862439 CDVKTDDsVVPCFMK intracellular localization; enzymatic activity, induced 26119734 1 1 0 regulates spindle assembly checkpoint and recruitment of SAC proteins -BRD4 BRD4 KINASE; Kinase, protein; Protein kinase, Ser/Thr (non-receptor); Protein kinase, atypical O60885 23476 19p13.12 human Y98-p 1874101904 KLNLPDYyKIIKTPM Bromodomain protein stabilization; molecular association, regulation; ubiquitination carcinogenesis, induced; chromatin organization, altered; transcription, induced BET1(DISRUPTS); STAT3(INDUCES); UCHL3(INDUCES) DNA(INDUCES) 34290255 1 1 0 inhibits ubiquitination -FOSL1 FRA1 DNA-binding; Transcription factor P15407 8061 11q13.1 human S265-p 478352 PSSDPLGsPTLLAL_ molecular association, regulation; protein stabilization carcinogenesis, induced; cell motility, induced; cell growth, induced; cytoskeletal reorganization AXL(INDUCES) 17371847; 21822309; 22286759 3 8 6 -CLASP2 CLASP2 Cytoskeletal; Motility/polarity/chemotaxis O75122 23122 3p22.3 human S537-p 22648007 REASRESsRDTSPVR molecular association, regulation; intracellular localization cytoskeletal reorganization EB1(DISRUPTS); IQGAP1(DISRUPTS) 19638411 1 3 0 inhibits binding with microtubules -Mknk2 Mnk2 EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, CAMK; Protein kinase, Ser/Thr (non-receptor); Translation Q8CDB0 17347 10|10 C1 mouse S434-p 456331 CLQLSPPsQSKLAQR molecular association, regulation ERK1(INDUCES) 16162500 1 3 2 -STAT5B STAT5B DNA-binding; Oncoprotein; Transcription factor P51692 6777 17q21.2 human S731-p 448751 TYMDQAPsPAVCPQA activity, induced; enzymatic activity, induced transcription, altered 17822672; 25006129 14 0 0 increases the basal transcriptional activity of the Y740/743 mutant comparing with the wt STAT5B -Rps6 S6 Translation P62754 20104 4|4 C4 mouse S235-p 448092 IAKRRRLsSLRASTS carcinogenesis, induced; carcinogenesis, inhibited; signaling pathway regulation; neural plasticity; cell growth, induced; autophagy, inhibited; translation, induced; transcription, inhibited 18851840; 23361300; 33826903; 34342159; 34426542; 34695513; 35428325; 37068088 246 60 972 Promotes axonal regeneration in the nervous systems -MAP3K7 TAK1 EC 2.7.11.25; KINASE; Kinase, protein; Protein kinase, Ser/Thr (non-receptor); Protein kinase, TKL O43318 6885 6q15 human S192-p 448289 HMTNNKGsAAWMAPE PK_Tyr_Ser-Thr phosphorylation; enzymatic activity, induced 15590691; 20538596 5 1 0 -Wnk4 WNK4 EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, Other; Protein kinase, Ser/Thr (non-receptor) Q80UE6 69847 11|11 D mouse K662-ub 40323302 QMRKNPVkTLRRRPR protein degradation 23576762 1 1 0 regulates electrolyte homeostasis and involved in Pseudohypoaldosteronism type II (PHAII) pathogenesis -Eps8 EPS8 Adaptor/scaffold Q08509 13860 6 G1|6 66.78 cM mouse T317-p 3801518 GPGEGVLtLRAKPPP cytoskeletal reorganization 25456499 1 18 12 spine development -ESR1 ER-alpha DNA-binding; Nuclear receptor; Transcription factor P03372 2099 6q25.1-q25.2 human K171-sm 27992517 RLASTNDkGSMAMES Oest_recep transcription, inhibited 22826433 1 1 0 ER-alpha SUMOylation suppresses ER transcriptional activation by full antiestrogens (AEs) in the absence of induced ER degradation -ERBB4 HER4 EC 2.7.10.1; KINASE; Kinase, protein; Membrane protein, integral; Protein kinase, TK; Protein kinase, tyrosine (receptor) Q15303 2066 2q34 human Y1221-p 4825108 NTLGKAEyLKNNILS molecular association, regulation GRB2(INDUCES) 16729043 1 1 0 -Ppp2r5b PPP2R5B Motility/polarity/chemotaxis; Protein phosphatase, regulatory subunit Q6PD28 225849 19|19 A mouse S44-p 10405463 RRARPRRsHSSSQFR molecular association, regulation; phosphorylation PPP2CA(INDUCES); PPP2R5B(INDUCES) 21329884 1 3 7 PPP2R2R5B phosphorylation by CLK2 is required for the PPP2CA-AKT complex; induces AKT dephosphorylation -Gata3 GATA3 Transcription factor P23772 14462 2 A1|2 6.69 cM mouse T155-p 33638003 HLFTFPPtPPKDVSP protein degradation 24820417 1 0 0 phosphorylated during G2/M phase -RRM2 RRM2 EC 1.17.4.1; Nucleotide Metabolism - purine; Nucleotide Metabolism - pyrimidine; Other Amino Acids Metabolism - glutathione; Oxidoreductase P31350 6241 2p25.1 human T33-p 3189775 SLVDKENtPPALSGT protein degradation; molecular association, regulation; ubiquitination; intracellular localization cell cycle regulation; DNA repair, inhibited CCNF(INDUCES) 22632967; 26602815 2 27 30 -FOXO3 FOXO3A Autophagy; DNA-binding; Oncoprotein; Transcription factor O43524 2309 6q21 human S315-p 449109 DFRSRTNsNASTVSG intracellular localization; activity, inhibited cell cycle regulation; apoptosis, inhibited; transcription, inhibited 11154281; 26376801 5 0 1 -Rbm20 RBM20 E9PT37 309544 1q55 rat S638-p 31086436 YGPERPRsRSPMSRS intracellular localization RNA splicing, altered; transcription, altered RNA(INDUCES) 35394688; 36140694 2 3 0 -Elk1 ELK1 DNA-binding; Transcription factor A4GTP4 314436 Xq11 rat S382-p 447872 IHFWSTLsPIAPRSP transcription, induced 21677150 45 1 0 -Mecp2 MECP2 Transcription, coactivator/corepressor Q00566 29386 Xq37 rat S292-p 25696402 KKAVKESsIRSVQET intracellular localization 25511996 1 1 0 localization of phosphorylated form from nucleus to cytoplasm. -DYRK2 DYRK2 iso2 EC 2.7.12.1; KINASE; Kinase, protein; Protein kinase, CMGC; Protein kinase, dual-specificity (non-receptor) Q92630-2 8445 12q15 human T32-p 1874397806 SNKRTVLtTQPNGLT intracellular localization; enzymatic activity, inhibited cell cycle regulation; apoptosis, induced 34363019 1 1 0 -VCP VCP Chaperone; DNA repair, damage; EC 3.6.4.6; Endoplasmic reticulum; Hydrolase P55072 7415 9p13.3 human S352-p 457556 AATNRPNsIDPALRR AAA apoptosis, inhibited 16551632 2 6 0 -FUS hnRNP P2 DNA-binding; Nuclear receptor co-regulator; Oncoprotein; RNA splicing; RNA-binding; SUMO LIGASE P35637 2521 16p11.2 human R524-me 1873375604 HRQDRRErPY_____ intracellular localization KPNB2(DISRUPTS) 22968170 1 0 0 Arginines in the RGG3 domain are required for nuclear import of mutant hnRNP, and arginine methylation in this domain reduces KPNB2 binding. -FGF14 FGF14 Cell development/differentiation; Cytokine Q92915 2259 13q33.1 human S228-p 54201601 PGVTPSKsTSASAIM activity, induced; intracellular localization SCN2A(INDUCES); SCN8A(INDUCES) 26917740 1 1 0 axodendritic polarity, FGF14 modulation of Nav mediated currents -BECN1 beclin 1 Adaptor/scaffold; Autophagy; Membrane protein, peripheral Q14457 8678 17q21.31 human Y229-p 28850302 LDQEEAQyQREYSEF APG6_N molecular association, regulation cell differentiation, inhibited; carcinogenesis, induced; autophagy, inhibited Bcl-2(INDUCES); beclin 1(INDUCES); rubicon(INDUCES); PIK3C3(DISRUPTS) 24034250; 29610308 2 0 0 kinase active HER2 -RASAL2 RASAL2 iso2 GAP; GAP, Ras Q9UJF2-2 9462 1q25.2 human S351-p 1872043503 TLFARTTsKTKADNI C2 molecular association, regulation carcinogenesis, induced; autophagy, induced beclin 1(INDUCES); PIK3C3(INDUCES); ATG14(INDUCES) 33563064 1 1 0 binding to PIK3C3 induces PIK3C3 bindidng to PtdIns -FOXO1 FOXO1A DNA-binding; Nuclear receptor co-regulator; Oncoprotein; Transcription factor Q12778 2308 13q14.11 human K265-ac 459033 DNNSKFAkSRSRAAK molecular association, regulation; intracellular localization; activity, inhibited; phosphorylation carcinogenesis, inhibited; apoptosis, induced; transcription, inhibited DNA(DISRUPTS) 15220471; 16076959; 18786403; 20519497; 27132507 9 1 0 -EHMT2 EHMT2 Amino Acid Metabolism - lysine degradation; EC 2.1.1.43; METHYLTRANSFERASE; Methyltransferase; Methyltransferase, protein lysine Q96KQ7 10919 6p21.33 human K1008-sm 1878097304 RLLQEFNkIEPPLIF molecular association, regulation; intracellular localization cell cycle regulation; cell growth, induced; transcription, induced PCAF(INDUCES) 30867409 1 0 0 SUMOylated G9a is recruited to E2F1 target gene promoters, EHMT2 is an activator of proliferation and E2F1-target gene expression -Nfe2l2 NRF2 DNA-binding; Transcription factor Q60795 18024 2 C3|2 44.75 cM mouse S347-p 18258502 NTSPSRAsPEHSVES protein degradation; molecular association, regulation BTRC(INDUCES) 21245377 3 1 0 -DDX3X DDX3 Cell cycle regulation; EC 3.6.4.13; Helicase; RNA-binding; Spliceosome; Translation initiation O00571 1654 Xp11.4 human T323-p 457784 GCHLLVAtPGRLVDM DEAD enzymatic activity, inhibited translation, altered; cell growth, altered 16280325; 17379183 2 12 1 -DCK DCK EC 2.7.1.74; Kinase, other; Nucleotide Metabolism - purine; Nucleotide Metabolism - pyrimidine P27707 1633 4q13.3 human T3-p 460584 _____MAtPPKRSCP protein stabilization; phosphorylation 20544527 3 6 0 -NFKB1 NFkB-p105 DNA-binding; Transcription factor P19838 4790 4q24 human K431-ac 465125 TKSNAGMkHGTMDTE molecular association, regulation; intracellular localization DNA(INDUCES) 11739381 1 1 1 nuclear translocation -CTDSPL2 CTDSPL2 EC 3.1.3.-; Motility/polarity/chemotaxis; PHOSPHATASE; Phosphatase Q05D32 51496 15q15.3-q21.1 human S134-p 4272262 EDNPSSGsPPRTTLL cell cycle regulation; carcinogenesis, induced; cell motility, induced; cell growth, induced; transcription, inhibited 34813892 1 9 0 -TP53 p53 Activator; DNA-binding; Motility/polarity/chemotaxis; Nuclear receptor co-regulator; Transcription factor; Tumor suppressor P04637 7157 17p13.1 human K386-ub 464662 RHKKLMFkTEGPDSD protein degradation; molecular association, regulation; intracellular localization transcription, induced; transcription, inhibited ING1(DISRUPTS) 10562557; 11046142; 17371868; 19927155; 21731648; 31002112 10 0 1 K370/372/373/381/382/386/R mutant shows 613-fold activation of p53; binds unmodified or six multimonoubiquitinated forms of wild-type p53; stimulates the transcriptional activity of p53; translocation of p53 from the nucleus to the cytoplasm, promotes EMT in EOC cells -UBTF UBF DNA-binding; Nucleolus; Transcription factor P17480 7343 17q21.31 human K232-m3 31094522 EVKDSLGkQWSQLSD HMG_box molecular association, regulation chromatin organization, altered; transcription, inhibited 24234436 1 1 0 -SLC6A3 DAT Membrane protein, integral; Membrane protein, multi-pass; Transporter; Transporter, SLC family Q01959 6531 5p15.33 human T62-p 451139 VEAQDREtWGKKIDF SNF protein conformation 19098122 2 0 0 -CREB1 CREB DNA-binding; Transcription factor P16220 1385 2q33.3 human K271-sm 12063903 PAEEAARkREVRLMK bZIP_1 protein stabilization transcription, induced 12552083 2 0 0 -GRK2 GRK2 EC 2.7.11.15; KINASE; Kinase, protein; Protein kinase, AGC; Protein kinase, Ser/Thr (non-receptor) P25098 156 11q13.2 human K30-ub 1872283503 TPAARASkKILLPEP protein degradation 17006543 1 0 0 -C3AR1 C3aR GPCR, family 1; Membrane protein, integral; Membrane protein, multi-pass; Receptor, GPCR Q16581 719 12p13.31 human T466-p 27145809 SEELTRStHCPSNNV receptor desensitization, induced; molecular association, regulation transcription, inhibited ARRB2(INDUCES) 23077507 1 0 0 -NPAT NPAT Cell cycle regulation; Transcription regulation Q14207 4863 11q22.3 human S779-p 2286402 ILSSPTKsPTKNAEL NPAT_C transcription, induced 10995387 1 2 0 multiple sites deletion mutant -HNRNPA1 hnRNP A1 Nuclear export; RNA splicing; RNA-binding; Spliceosome P09651 3178 12q13.13 human R225-m2 476707 RGGNFSGrGGFGGSR molecular association, regulation Ebp1(INDUCES); CCND1(INDUCES) 31473880 2 6 21 -NRGN neurogranin Cell development/differentiation Q92686 4900 11q24.2 human S36-p 455913 AAAKIQAsFRGHMAR IQ phosphorylation 17505539; 25303525 6 5 0 CREB phosphorylation; inhibits ERK phosphorylation -Mapt Tau ACETYLTRANSFERASE; Acetyltransferase; Cytoskeletal P10637 17762 11 67.79 cM|11 E1 mouse S506-p 447929 GSRSRTPsLPTPPTR molecular association, regulation AKAP5(INDUCES); PKAR2B(INDUCES); PKACB(INDUCES) 10460255 63 24 42 -COPS5 COPS5 Adaptor/scaffold; DEUBIQUITINASE; EC 3.4.-.-; Nuclear receptor co-regulator; Protease; Transcription, coactivator/corepressor; Translation Q92905 10987 8q13.1 human S177-p 1874115102 IDPTRTIsAGKVNLG carcinogenesis, induced; cell motility, induced; cell growth, induced; transcription, induced 34244488 1 1 0 -PTH1R PTHR GPCR, family 2; Membrane protein, integral; Membrane protein, multi-pass; Receptor, GPCR Q03431 5745 3p21.31 human K484-ub 15496531 WTLALDFkRKARSGS ubiquitination 29444827 1 1 1 abrogation of phosphorylation at positions T387and T392 dramatically decreased PTHR ubiquitination -Dlg4 PSD-95 Adaptor/scaffold P31016 29495 10q24 rat Y523-p 4093600 REDSVLSyETVTQME activity, induced 18721130 3 0 0 -SOS1 SOS1 Adaptor/scaffold; GEF; GEF, Ras; Motility/polarity/chemotaxis Q07889 6654 2p22.1 human S1161-p 9413177 PPRRRPEsAPAESSP molecular association, regulation signaling pathway regulation 14-3-3 epsilon(INDUCES) 22827337 1 5 16 -Cers2 LASS2 DNA-binding; Membrane protein, integral; Membrane protein, multi-pass; Transferase Q924Z4 76893 3|3 F2.1 mouse S349-p 469771 DREETESsEGEETAA enzymatic activity, induced 26887952 1 43 198 -IRAK1 IRAK1 EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, Ser/Thr (non-receptor); Protein kinase, TKL P51617 3654 Xq28 human T209-p 450949 LCEISRGtHNFSEEL molecular association, regulation; protein conformation; phosphorylation; enzymatic activity, induced signaling pathway regulation TRAF6(INDUCES) 14625308; 31511642 5 1 0 induces MAPK and NF-kB signaling pathways by inducing phosphorylation of JNK and ERK -SREBF1 SREBP-1 DNA-binding; Membrane protein, integral; Membrane protein, multi-pass; Transcription factor P36956 6720 17p11.2 human T59-p 900975702 AGSGAGGtDPASPDT protein stabilization cell growth, induced; transcription, induced PKM(INDUCES) 29514980 1 0 0 PKM2 interaction with nuclear SREBP-1a increases SREBP-target gene expression and subsequent lipid biosynthesis in cancer cells. -Mapk7 ERK5 EC 2.7.11.24; KINASE; Kinase, protein; Protein kinase, CMGC; Protein kinase, Ser/Thr (non-receptor) Q9WVS8 23939 11|11 B2 mouse K22-sm 2887212 GEPPGRVkAEPVHTA molecular association, regulation apoptosis, induced; transcription, inhibited; signaling pathway regulation SRC-1(DISRUPTS) 18218985; 18467627 4 0 0 -PCBP1 hnRNP E1 RNA splicing; RNA-binding; Translation Q15365 5093 2p13.3 human T60-p 478358 NCPERIItLTGPTNA KH_1 molecular association, regulation; intracellular localization RNA splicing, induced; transcription, induced; translation, induced; signaling pathway regulation DNA(INDUCES); RNA(DISRUPTS) 17389360 1 0 0 PKA-hnRNPE1 pathway -BRF1 GTF3B Transcription initiation complex Q92994 2972 14q32.33 human S450-p 3208533 GDGELDLsGIDDLEI BRF1 molecular association, regulation cell cycle regulation; transcription, induced GTF3C1(INDUCES) RNA(INDUCES) 22281053 1 6 0 induce POLIII transcription; binds to tRNA and 5SrRNA genes -Glp1r GLP1R GPCR, family 2; Membrane protein, integral; Membrane protein, multi-pass; Receptor, GPCR P32301 25051 20p12 rat S416-p 1867747800 VQMEFRKsWERWRLE molecular association, regulation; intracellular localization cell growth, induced KPNA2(DISRUPTS) 32010959 1 0 0 -BRSK2 BRSK2 EC 2.7.11.1; EC 2.7.11.26; KINASE; Kinase, protein; Protein kinase, CAMK; Protein kinase, Ser/Thr (non-receptor) Q8IWQ3 9024 11p15.5 human T174-p 456031 VGDSLLEtSCGSPHY Pkinase cytoskeletal reorganization 34936879 5 1 1 -Ido1 INDO Amino Acid Metabolism - tryptophan; Cell cycle regulation; EC 1.13.11.52; Oxidoreductase P28776 15930 8|8 A2 mouse Y115-p 21393600 PRNIAVPyCELSEKL IDO molecular association, regulation transcription, induced; signaling pathway regulation SHP-2(INDUCES); SHP-1(INDUCES) 21804557 1 0 0 Phosphorylation of INDO at Y115 and Y253 induced enzyme activity of SHP-1/SHP-2. -IGF2BP2 IGF2BP2 RNA-binding; Translation Q9Y6M1 10644 3q27.2 human K509-sm 1881342900 FNPKEEVkLEAHIRV protein stabilization cell growth, induced 34345216 1 0 0 promotes vasculogenic mimicry (VM) formation in glioma cells -H2BC3 H2B DNA-binding P33778 3018 6p22.2 human K20-ac 465512 GSKKAITkAQKKDGK Histone transcription, altered 16283522; 17560255 6 10 232 -CD6 CD6 Cell surface; Membrane protein, integral P30203 923 11q12.2 human S567-p 28095007 SNSESSTsSGEDYCN phosphorylation signaling pathway regulation 23711376 1 0 0 ERK1/2 phosphorylation, MAPK pathway activation -DNMT1 DNMT1 Amino Acid Metabolism - cysteine and methionine; Cell development/differentiation; EC 2.1.1.37; METHYLTRANSFERASE; Methyltransferase; Methyltransferase, DNA; Transcription regulation P26358 1786 19p13.2 human K891-ac 25171010 PTEDNKFkFCVSCAR cell cycle regulation 21947282 1 1 0 -Esrrg ERR3 DNA-binding; Nuclear receptor; Transcription factor P62509 26381 1|1 H5-H6 mouse K40-sm 6048402 SSCSSFIkTEPSSPA transcription, inhibited 18063693 2 0 0 -Cryaa CRYA1 Chaperone; Heat shock protein P24623 24273 20p12 rat S145-p 452106 HRRYRLPsNVDQSAL HSP20 apoptosis, inhibited 22414529 2 6 1 cytoprotective effect -IKBKG IKKG Adaptor/scaffold; Protein kinase, regulatory subunit Q9Y6K9 8517 Xq28 human S43-p 449037 PAMLHLPsEQGAPET sumoylation; molecular association, regulation; ubiquitination; intracellular localization transcription, induced; signaling pathway regulation IKKB(INDUCES) 31932854 4 2 0 induces NF-KB pathway and induces NF-KB activation/transcription -RHOA RHOA G protein; G protein, monomeric; G protein, monomeric, Rho; Motility/polarity/chemotaxis; Oncoprotein P61586 387 3p21.31 human Y42-p 150180312 VPTVFENyVADIEVD Ras protein degradation; molecular association, regulation; ubiquitination; intracellular localization carcinogenesis, inhibited; cell motility, induced; cell growth, induced; transcription, induced; signaling pathway regulation ROCK1(INDUCES); VAV2(INDUCES); RhoGDI alpha(DISRUPTS); CTNNB1(INDUCES); ROCK1(DISRUPTS); ROCK2(INDUCES); IKKG(INDUCES) 28712859; 31056743; 31973815; 33388549 7 0 0 induces superoxide production pathway; super oxide production -NELFE RDBP Mitochondrial; Transcription, coactivator/corepressor P18615 7936 6p21.33 human S49-p 3181405 SQGGVKRsLSEQPVM molecular association, regulation transcription, induced 14-3-3 epsilon(INDUCES) 29523821 1 23 2 dissociation of the NELF complex from chromatin, which is accompanied by RNA polymerase II elongation -MAP4 MAP4 Cytoskeletal; Motility/polarity/chemotaxis P27816 4134 3p21.31 human T521-p 452281 MALGKDVtPPPETEV protein degradation; molecular association, regulation carcinogenesis, inhibited; cell growth, inhibited FBXW7(INDUCES) 36991467 1 61 43 -MAPT Tau iso8 ACETYLTRANSFERASE; Acetyltransferase; Cytoskeletal P10636-8 4137 17q21.31 human S289-p 487456 LDLSNVQsKCGSKDN Tubulin-binding molecular association, regulation; protein conformation Tau iso8(INDUCES); Tau(INDUCES) 21204788; 36003083; 36786552 6 3 0 -Kcnb1 Kv2.1 Channel, cation; Channel, ligand-gated; Channel, potassium; Membrane protein, integral; Membrane protein, multi-pass P15387 25736 3q42 rat S444-p 4714867 ERAKRNGsIVSMNMK activity, induced 22006306 1 5 0 -ADRB2 ADRB2 GPCR, family 1; Membrane protein, integral; Membrane protein, multi-pass; Receptor, GPCR P07550 154 5q32 human Y141-p 449832 AITSPFKyQSLLTKN 7tm_1 activity, induced 8521811 4 0 0 -Cacng2 Stargazin Channel, calcium; Membrane protein, integral; Membrane protein, multi-pass Q71RJ2 84347 7q34 rat S241-p 455317 QRRSRSSsRSTEPSH molecular association, regulation neural plasticity PSD-95(INDUCES) 25843401 3 0 0 -CDK2AP1 CDK2AP1 Cell cycle regulation; DNA replication; Tumor suppressor O14519 8099 12q24.31 human S46-p 25126700 LSDYGPPsLGYTQGT CDK2AP molecular association, regulation; protein conformation 22427660 1 1 0 -PITPNC1 PITPNC1 Lipid-binding Q9UKF7 26207 17q24.2 human S274-p 454503 SVRSAPSsAPSTPLS activity, induced; protein stabilization; molecular association, regulation 14-3-3 beta(INDUCES); 14-3-3 epsilon(INDUCES) 21728994; 26977884 2 5 3 -Vasp VASP Cytoskeletal; Motility/polarity/chemotaxis P70460 22323 7|7 A3 mouse S317-p 469024 TTLPRMKsSSSVTTS molecular association, regulation cell adhesion, induced 21945940 3 15 45 increased actin filament binding in vitro, increased aggregation of cells, increased VASP at cell-cell adhesions -Ces1d CES1D iso2 EC 3.1.1.1; EC 3.1.1.67 NP_579829 113902 19p11 rat S506-p 3540200 ANFARNGsPNGGGLP COesterase enzymatic activity, induced 15866484 2 0 0 increases cholesterol esterase activities and decreases PNPA esterase (change of substrate specificity from water soluble to hydrophobic substrates) -NR3C2 MCR DNA-binding; Nuclear receptor P08235 4306 4q31.23 human S227-p 25692900 FGSFPVHsPITQGTP protein degradation; ubiquitination transcription, inhibited 22798426 1 0 0 -POU3F2 Oct7 DNA-binding; Motility/polarity/chemotaxis; Transcription factor P20265 5454 6q16.1 human T440-p 4928201 PPHHGVQtPVQ____ DNA repair, altered; signaling pathway regulation DNA(INDUCES) 30804224 1 0 4 -KHDRBS1 KHDRBS1 RNA-binding Q07666 10657 1p35.2 human T33-p 7990374 AHPSVRQtPSRQPPL molecular association, regulation; intracellular localization; protein conformation cell cycle regulation; RNA splicing, inhibited; cell growth, induced; apoptosis, inhibited RNA(DISRUPTS) 36537190 1 10 3 -ABL1 Abl EC 2.7.10.2; KINASE; Kinase, protein; Oncoprotein; Protein kinase, TK; Protein kinase, tyrosine (non-receptor) P00519 25 9q34.12 human S619-p 1779805 PTPPKRSsSFREMDG molecular association, regulation; phosphorylation; enzymatic activity, induced Abi-2(DISRUPTS) 18161990 1 0 0 interaction in vitro and in vivo; phosphorylation of this site enhances the association and phosphorylation of the Abl substrate, Crk. -Junb JunB Motility/polarity/chemotaxis; Oncoprotein; Transcription factor P09450 16477 8 C3|8 41.41 cM mouse K301-sm 3144821 EDKVKTLkAENAGLS bZIP_1 intracellular localization transcription, induced 18424718 1 1 0 -Kcnj16 Kir5.1 Membrane protein, integral; Membrane protein, multi-pass P52191 29719 10q32.1 rat S417-p 451508 LNRISMEsQM_____ molecular association, regulation; intracellular localization; activity, inhibited PSD-95(DISRUPTS) 11988170 1 0 0 -APAF1 APAF Apoptosis O14727 317 12q23.1 human K224-ub 21129052 PLNIEEAkDRLRILM NB-ARC molecular association, regulation; ubiquitination SQSTM1(INDUCES) 31329620 1 3 0 binds and forms aggregates in the cytosol, activates caspase-9 in cells that stably express bcl-xl -Pnpla2 PNPLA2 EC 3.1.1.3; Lipase; Membrane protein, integral Q8BJ56 66853 7|7 F5 mouse S406-p 473045 VELRRAQsLPSVPLS molecular association, regulation; enzymatic activity, induced 14-3-3 beta(INDUCES) 21641555; 34352257 8 29 54 -HAS2 HAS2 EC 2.4.1.212; Membrane protein, integral; Membrane protein, multi-pass; Motility/polarity/chemotaxis; Transferase Q92819 3037 8q24.13 human K190-ub 14991106 IMQKWGGkREVMYTA enzymatic activity, induced 20507985 2 1 0 -GTF2I GTF2I iso2 DNA-binding; Transcription, coactivator/corepressor P78347-2 2969 7q11.23 human S633-p 452350 QSPKRPRsPGSNSKV transcription, altered 10648599 1 19 33 -TFAP2A AP-2 alpha DNA-binding; Transcription factor P05549 7020 6p24.3 human S258-p 5024712 GVLRRAKsKNGGRSL TF_AP-2 molecular association, regulation transcription, altered DNA(INDUCES) 18845787 2 0 0 -KLF8 KLF8 C2H2-type zinc finger protein; DNA-binding; Transcription factor O95600 11279 Xp11.21 human K67-sm 3726909 PALFNDIkIEPPEEL cell cycle regulation; transcription, altered 16617055 2 0 0 -XRCC1 XRCC1 DNA repair, damage P18887 7515 19q13.31 human Y515-p 40274401 EENGEDPyAGSTDEN molecular association, regulation PARP1(DISRUPTS) 25477519 1 1 0 -Creb1 CREB iso1 DNA-binding; Transcription factor P15337-1 81646 9q32 rat S133-p 448228 EILSRRPsYRKILND pKID activity, induced; molecular association, regulation; intracellular localization; protein conformation neural plasticity; cell growth, induced; transcription, induced; signaling pathway regulation; transcription, altered; cell growth, altered CREM iso2(INDUCES); CBP(INDUCES) DNA(INDUCES) 10722651; 10804193; 11013247; 11094091; 11123304; 11278709; 11701463; 11731096; 11796524; 11970864; 12114502; 12162494; 12163549; 14597636; 15522277; 17337597; 18378685; 19943942; 21949366; 28716938; 32111982; 34635097; 35053838; 35260079; 7958915; 8688081; 8887554; 9413984; 9687510; 9829964 311 5 61 -Oprm1 MOR-1 GPCR, family 1; Membrane protein, integral; Membrane protein, multi-pass; Receptor, GPCR P33535 25601 1q11 rat T357-p 3063303 FCIPTSStIEQQNST receptor desensitization, altered; phosphorylation 12123746 1 1 0 -HIPK2 HIPK2 EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, CMGC; Protein kinase, Ser/Thr (non-receptor) Q9H2X6 28996 7q34 human Y361-p 449571 SKAVCSTyLQSRYYR Pkinase protein stabilization; molecular association, regulation; intracellular localization; protein conformation; phosphorylation cell cycle regulation; apoptosis, induced; cell growth, inhibited; signaling pathway regulation; transcription, inhibited SIAH2(INDUCES); PIN1(INDUCES) 23000554; 24196445; 31387937; 31519758 6 78 3324 -SCN1A SCN1A Channel, sodium; Membrane protein, integral; Membrane protein, multi-pass P35498 6323 2q24.3 human S1918-p 36276481 KRKQEEVsAVIIQRA molecular association, regulation Calmodulin(INDUCES) 30142967 1 1 0 -SUV39H1 SUV39H1 Amino Acid Metabolism - lysine degradation; EC 2.1.1.43; METHYLTRANSFERASE; Methyltransferase; Methyltransferase, protein lysine O43463 6839 Xp11.23 human Y303-p 1871199001 TYLFDLDyVEDVYTV SET methylation; enzymatic activity, induced signaling pathway regulation 30833073 1 0 0 NRG-1/ErbB4 signaling -Crem CREM DNA-binding; Transcription factor P27699 12916 18|18 A1 mouse S290-p 450066 ASPGSLHsPQQLAEE activity, inhibited transcription, altered 8114763 4 12 1 -PRKD1 PRKD1 Autophagy; EC 2.7.11.13; KINASE; Kinase, protein; Motility/polarity/chemotaxis; Protein kinase, CAMK; Protein kinase, Ser/Thr (non-receptor) Q15139 5587 14q12 human S910-p 447632 KALGERVsIL_____ enzymatic activity, inhibited; phosphorylation; enzymatic activity, induced signaling pathway regulation 16563698; 19029298; 21285358; 34767572 43 13 0 autophosphorylation of this site activates NLRP3; NLRP3 inhibition prevents phosphorylation of this site -Hnrnpf hnRNP F RNA splicing; RNA-binding; Spliceosome Q794E4 64200 4q42 rat K224-ub 486692 RRYIGIVkQAGLDRM protein stabilization RNA splicing, induced 25959059 1 9 73 -SLC5A5 SLC5A5 Membrane protein, integral; Membrane protein, multi-pass; Transporter; Transporter, SLC family Q92911 6528 19p13.11 human S43-p 990307 LARGGQRsAEDFFTG activity, induced 17913707 1 1 1 -PAG1 PAG Adaptor/scaffold; Membrane protein, integral Q9NWQ8 55824 8q21.13 human Y299-p 1806902 KRFSSLSyKSREEDP PAG molecular association, regulation LYN(INDUCES) 18070987 1 0 0 -CDK7 CDK7 Cell cycle regulation; EC 2.7.11.22; EC 2.7.11.23; KINASE; Kinase, protein; Nuclear receptor co-regulator; Protein kinase, CMGC; Protein kinase, Ser/Thr (non-receptor) P50613 1022 5q13.2 human S164-p 450041 GLAKSFGsPNRAYTH Pkinase molecular association, regulation; protein conformation; enzymatic activity, induced cell cycle regulation; cell growth, induced; cytoskeletal reorganization; transcription, altered MAT1A(INDUCES) 32855301; 35337817; 9832506 4 52 21 -TERT TERT DNA-binding; EC 2.7.7.49; Nucleolus; Transferase O14746 7015 5p15.33 human Y707-p 450084 QDPPPELyFVKVDVT molecular association, regulation; intracellular localization apoptosis, altered RAN(INDUCES) 12808100; 18829466; 20211239; 24413564 5 0 0 -BECN1 beclin 1 Adaptor/scaffold; Autophagy; Membrane protein, peripheral Q14457 8678 17q21.31 human K263-ub 964501094 YAQTQLDkLKKTNVF protein stabilization; molecular association, regulation autophagy, inhibited beclin 1(INDUCES) 31848340 1 2 0 LATS1 induces inactive Beclin-1 dimerization and inhibition of autophagy -Ppp1r12a MYPT1 Motility/polarity/chemotaxis; PHOSPHATASE; Protein phosphatase, regulatory subunit Q10728 116670 7q21 rat S473-p 3174680 GVIRSASsPRLSSSL molecular association, regulation PLK1(INDUCES) 18477460 2 9 7 -KCNJ1 ROMK Channel, potassium; Membrane protein, integral; Membrane protein, multi-pass P48048 3758 11q24.3 human S4-p 2813507 ____MNAsSRNVFDT activity, induced; intracellular localization 12221079 2 0 0 -Dcx Doublecortin Cytoskeletal; Motility/polarity/chemotaxis Q9ESI7 84394 Xq33-q34 rat S332-p 451363 STPKSKQsPISTPTS cell growth, altered 21159948 7 4 14 controls axon branching morphogenesis -Nde1 NUDE1 Cell cycle regulation; Cytoskeletal; Microtubule-binding Q9CZA6 67203 16|16 A1 mouse Y279-p 448969 ASCRNFMyDQSPSRT NUDE_C molecular association, regulation PAFAH1B1(DISRUPTS) 29562183 1 9 250 -FUS hnRNP P2 iso2 DNA-binding; Nuclear receptor co-regulator; Oncoprotein; RNA splicing; RNA-binding; SUMO LIGASE P35637-2 2521 16p11.2 human K333-sm 580826268 DRETGKLkGEATVSF RRM_1 protein stabilization autophagy, inhibited 32069702 1 1 0 promotes hnRNPD-mediated ATG4D stability -ERBB2 HER2 EC 2.7.10.1; KINASE; Kinase, protein; Membrane protein, integral; Oncoprotein; Protein kinase, TK; Protein kinase, tyrosine (receptor) P04626 2064 17q12 human K716-ub 964518778 QAQMRILkETELRKV protein degradation; ubiquitination cell growth, inhibited 33875644 1 1 0 -NEDD4 NEDD4 iso4 EC 6.3.2.-; EC 6.3.2.19; Ligase; Nuclear receptor co-regulator; UBIQUITIN LIGASE; Ubiquitin conjugating system; Ubiquitin ligase P46934-4 4734 15q21.3 human T229-p 478103 PTPQDNLtDAENGNI molecular association, regulation; ubiquitination NDFIP1(INDUCES) 31578285 1 26 5 Regulates autoubiquitination -ATP5F1A ATP5A1 EC 3.6.3.14; Energy Metabolism - oxidative phosphorylation; Hydrolase; Membrane protein, integral; Mitochondrial; Transporter P25705 498 18q21.1 human Y243-p 461991 SDEKKKLyCIYVAIG ATP-synt_ab molecular association, regulation; phosphorylation carcinogenesis, induced; cell growth, induced; apoptosis, inhibited; autophagy, inhibited ATPIF1(DISRUPTS) 35895804 1 0 28 inhibits phosphorylation of downstream proteins -DBN1 DBN1 iso3 Actin-binding; Cytoskeletal; Motility/polarity/chemotaxis Q16643-3 1627 5q35.3 human S142-p 452446 NGLARLSsPVLHRLR intracellular localization cytoskeletal reorganization 24637538 6 87 28 Phospho-drebrin was localized at the distal part of total drebrin in the growth cone. -METTL3 METTL3 EC 2.1.1.62; METHYLTRANSFERASE; Methyltransferase; RNA processing Q86U44 56339 14q11.2 human S67-p 1876371800 GPKPSTAsAVPELAT molecular association, regulation transcription, induced; translation, induced EEF1G(INDUCES); Elf-2(INDUCES); RPSA(INDUCES) 35172162 1 1 0 -TERF2 TRF2 DNA repair, damage; DNA-binding Q15554 7014 16q22.1 human R72-me 10338218 SGRARRGrHEPGLGG cell cycle regulation; cell growth, altered 19596784 1 0 0 -SSTR5 SSTR5 Cell cycle regulation; GPCR, family 1; Membrane protein, integral; Membrane protein, multi-pass; Receptor, GPCR P35346 6755 16p13.3 human T247-p 1779800 RRSERKVtRMVLVVV 7tm_1 molecular association, regulation; receptor internalization, altered ARRB2(INDUCES) 18096696 1 0 0 -CHUK IKKA EC 2.7.11.10; KINASE; Kinase, protein; Protein kinase, Other; Protein kinase, Ser/Thr (non-receptor) O15111 1147 10q24.31 human T23-p 447780 EMRERLGtGGFGNVC Pkinase phosphorylation; enzymatic activity, induced apoptosis, altered; apoptosis, inhibited; transcription, induced; transcription, altered 12048203; 18515365; 18794113; 19609947 7 4 0 -ATF2 ATF-2 ACETYLTRANSFERASE; C2H2-type zinc finger protein; EC 2.3.1.48; Transcription factor P15336 1386 2q31.1 human T73-p 451439 ADQTPTPtRFLKNCE activity, induced; protein stabilization transcription, induced 15105425 4 10 9 -Mzf1 MZF-1 C2H2-type zinc finger protein; DNA-binding; Transcription factor O70162 109889 7 A1|7 7.73 cM mouse S374-p 448856 SLSGQIQsPTTEGGF activity, inhibited 12427756 1 0 0 S295A substitution correlates with increased transactivation activity, implying that phosphorylation can inhibit the transcriptional activation of MZF-2A. Substitution of three sites (S257/275/295A) further inhibited transcription, suggesting that phosphorylation of these three residues cooperatively inhibits transactivation. -CD28 CD28 Cell surface; Membrane protein, integral P10747 940 2q33.2 human Y209-p 450284 TRKHYQPyAPPRDFA activity, induced; molecular association, regulation; phosphorylation carcinogenesis, inhibited; cell growth, inhibited; transcription, induced; signaling pathway regulation CSK(INDUCES); Lck(INDUCES) 20368329; 21964608; 30131370; 31292214 7 8 276 -GYS1 GYS1 Carbohydrate Metabolism - starch and sucrose; EC 2.4.1.11; Transferase P13834 100008660 rabbit S645-p 448238 RPASVPPsPSLSRHS Glycogen_syn enzymatic activity, inhibited 10909964; 6402364; 7759494; 7929255; 8226927; 8546708 21 32 7 -CRTC2 TORC2 Transcription, coactivator/corepressor Q53ET0 200186 1q21.3 human S171-p 454622 SALNRTSsDSALHTS TORC_M transcription, inhibited 16684769 19 10 12 -GJA1 GJA1 Channel, misc.; Membrane protein, integral; Membrane protein, multi-pass; Motility/polarity/chemotaxis P17302 2697 6q22.31 human Y286-p 465296 SPMSPPGyKLVTGDR Connexin43 protein degradation; ubiquitination 24399133 1 2 11 -POLH POLH DNA repair, damage; EC 2.7.7.7; Transferase Q9Y253 5429 6p21.1 human K453-sm 1877365906 SDPSSLPkVPVTSSE intracellular localization; enzymatic activity, inhibited 32350109 1 1 0 -SOCS3 SOCS3 Inhibitor O14543 9021 17q25.3 human K6-ub 486270 __MVTHSkFPAAGMS protein degradation 12459551 1 0 0 -SCN5A SCN5A Channel, sodium; Membrane protein, integral; Membrane protein, multi-pass Q14524 6331 3p22.2 human Y1495-p 455660 TEEQKKYyNAMKKLG activity, induced; protein conformation; activity, inhibited 15831816; 34373326 2 0 0 Induce destabilization of the IFM peptide; leads to a depolarizing shift in steady state inactivation; regulates Nav1.5 function -Gata1 GATA1 DNA-binding; Transcription factor P17679 14460 X A1.1|X 3.59 cM mouse S142-p 451235 TLKTERLsPDLLTLG protein degradation; acetylation; ubiquitination; phosphorylation DNA(INDUCES) 16858405 3 0 0 Phosphorylation and acetylation cause the degradation of acetylated GATA-1; DNA binding is required for MAPK-dependent phosphorylation -TLR3 TLR3 Membrane protein, integral; Receptor, cytokine O15455 7098 4q35.1 human K831-ub 1877171200 DPLCKRFkVHHAVQQ TIR molecular association, regulation; intracellular localization signaling pathway regulation VPS36(INDUCES); STAM2(INDUCES); STAM1(INDUCES); Hrs(INDUCES) 32878999 1 0 0 TLR3-mediated signaling, TLR3 trafficking from the Golgi apparatus to endosomes, sorting of polyubiquitinated TLR3 by the ESCRT complexes -Ahcyl1 AHCYL1 Amino Acid Metabolism - cysteine and methionine; EC 3.3.1.1; Hydrolase; Other Amino Acids Metabolism - selenoamino acid Q80SW1 229709 3 F2.3|3 46.83 cM mouse S68-p 467244 RSLSRSIsQSSTDSY molecular association, regulation; phosphorylation PIP4K2A(INDUCES); PPP1CA(INDUCES); PIP5K1A(INDUCES); IP3R1(INDUCES) 16793548; 17635105; 26509711 6 1 1 -MAPK14 P38A EC 2.7.11.24; KINASE; Kinase, protein; Protein kinase, CMGC; Protein kinase, Ser/Thr (non-receptor) Q16539 1432 6p21.31 human K139-me 1884812101 YQILRGLkYIHSADI protein stabilization; enzymatic activity, induced 35992062 1 1 0 -Esr2 ER-beta DNA-binding; Nuclear receptor O08537 13983 12 C3|12 33.52 cM mouse S75-p 1023700 GPVRQTAsPNVLWPT ERbeta_N protein degradation; molecular association, regulation; ubiquitination; intracellular localization transcription, inhibited UBE3A(INDUCES) 17962381 1 0 0 -CDKN1A p21Cip1 Cell cycle regulation; Inhibitor P38936 1026 6p21.2 human R156-m2 50760801 DFYHSKRrLIFSKRK intracellular localization 26436589 1 0 0 cytoplasmic localization of p21 -Fzd3 FZD3 GPCR, Fz/Smo family; Membrane protein, integral; Membrane protein, multi-pass; Receptor, GPCR Q61086 14365 14 D1|14 34.09 cM mouse S509-p 18507007 KTCFEWAsFFHGRRK Frizzled receptor internalization, inhibited; phosphorylation endocytosis, inhibited 21316586 1 0 0 enhances PCP signaling, regulating c-Jun phosphorylation, and affecting growth cone guidance -Cacng2 Stargazin Channel, calcium; Membrane protein, integral; Membrane protein, multi-pass Q71RJ2 84347 7q34 rat S249-p 455320 RSTEPSHsRDASPVG molecular association, regulation neural plasticity PSD-95(INDUCES) 25843401 3 1 1 -TIFA TIFA Q96CG3 92610 4q25 human T177-p 4743087 SSQSSSPtEMDENES molecular association, regulation; phosphorylation signaling pathway regulation TRAF6(DISRUPTS) 36098982 1 2 0 inhibits IKK and MAPK phosporylation; regulates ADP-heptose signaling -Cask CASK Adaptor/scaffold; EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, CAMK; Protein kinase, Ser/Thr (non-receptor) Q62915 29647 Xq12 rat K679-sm 3173812 CIAMEKTkQEQQASC molecular association, regulation; intracellular localization cytoskeletal reorganization ACTB(DISRUPTS); EPB41(DISRUPTS) 18606847 1 0 0 -CIITA CIITA DNA-binding; EC 2.7.11.1; KINASE; Protein kinase, Ser/Thr (non-receptor); Transcription, coactivator/corepressor P33076 4261 16p13.13 human S288-p 2286408 PDRPGSTsPFAPSAT molecular association, regulation; intracellular localization; activity, inhibited transcription, altered Exportin-1(INDUCES) 15210796; 18245089 2 0 0 -TPI1 TPI1 Carbohydrate Metabolism - fructose and mannose; Carbohydrate Metabolism - glycolysis and gluconeogenesis; Carbohydrate Metabolism - inositol phosphate; EC 5.3.1.1; Isomerase P60174 7167 12p13.31 human S21-p 465652 KMNGRKQsLGELIGT TIM molecular association, regulation carcinogenesis, inhibited TPI1(DISRUPTS) 36715544 3 67 124 -TTK TTK Cancer Testis Antigen (CTA); EC 2.7.12.1; KINASE; Kinase, protein; Protein kinase, Other; Protein kinase, dual-specificity (non-receptor) P33981 7272 6q14.1 human T686-p 487541 VKDSQVGtVNYMPPE Pkinase enzymatic activity, induced cell cycle regulation 17728254; 18545697; 18680479; 19120698 9 5 0 -GRIK2 GluR6 Channel, calcium; Channel, ligand-gated; Membrane protein, integral; Membrane protein, multi-pass Q13002 2898 6q16.3 human S868-p 478417 MVEELRMsLKCQRRL sumoylation; receptor internalization, induced; receptor recycling, induced; intracellular localization; phosphorylation; palmitoylation neural plasticity; endocytosis, altered 22522402; 37868810 7 0 0 PMA induced colocalization with EEA1 and TfR, and S868 phosphorylation increases recycling of GluKR6 ; palmitoylation maintains surface expression and regulates agonist -induced internalisation; long-term depression (LTD) of KAR receptor mediated synaptic transmission -MAVS MAVS Adaptor/scaffold; Membrane protein, integral Q7Z434 57506 20p13 human S442-p 58984003 CFEDLAIsASTSLGM molecular association, regulation; phosphorylation signaling pathway regulation IRF3(INDUCES) 25636800; 31461653 2 1 0 induces phosphorylation of IRF3, regulates IFN signaling; induces IFN production -Stk24 MST3 EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, STE; Protein kinase, Ser/Thr (non-receptor) Q99KH8 223255 14 E5|14 64.95 cM mouse S79-p 33602703 TVLSQCDsPYVTKYY Pkinase cell motility, induced 24872548 1 0 0 -WASF2 WAVE2 Actin-binding; Motility/polarity/chemotaxis Q9Y6W5 10163 1p36.11 human S482-p 6377642 RRIAVEYsDSEDDSS activity, inhibited cytoskeletal reorganization 19012317 1 0 0 -NUP50 NUP50 Nuclear import; Nucleoporin Q9UKX7 10762 22q13.31 human S221-p 476622 KVAAETQsPSLFGST molecular association, regulation KPNB1(DISRUPTS) 19767751 1 32 18 -DAB2 DAB2 Adaptor/scaffold; Tumor suppressor P98082 1601 5p13.1 human S401-p 452352 SPNPFVGsPPKGLSI molecular association, regulation CLTA(INDUCES) 21097498 2 41 0 -MSX2 MSX2 DNA-binding; Transcription, coactivator/corepressor P35548 4488 5q35.2 human T135-p 25554905 HMSPTTCtLRKHKTN protein stabilization cell differentiation, inhibited; transcription, inhibited 22633971 1 0 0 -Gabrg2 GABRG2 Channel, chloride; Channel, ligand-gated; Membrane protein, integral; Membrane protein, multi-pass; Transporter; Transporter, ion channel Q6PW52 29709 10q21 rat S329-p 1869465807 RKSLPKVsYVTAMDL Neur_chan_memb intracellular localization neural plasticity; signaling pathway regulation 31618635 1 0 0 Nogo-A signaling -P2rx1 P2X1 Channel, ligand-gated; Membrane protein, integral; Membrane protein, multi-pass P47824 rat T18-p 3251800 AFFFEYDtPRMVLVR P2X_receptor activity, induced 14614959 1 0 0 T18A and T19N mutations abolishes receptor current. -CDKN1B p27Kip1 Cell cycle regulation; Inhibitor; Oncoprotein; Protein kinase, regulatory subunit P46527 1027 12p13.1 human K153-ub 5018204 EQCAGIRkRPATDDS protein degradation cell cycle regulation 10318797; 19056892 2 1 0 -Ikbkb IKKB EC 2.7.11.10; KINASE; Kinase, protein; Protein kinase, Other; Protein kinase, Ser/Thr (non-receptor) O88351 16150 8|8 A2 mouse S705-p 17934902 LPESDKKsEELVAEA molecular association, regulation; phosphorylation PPP2R3C(INDUCES) 20925653 1 0 0 interaction with PPP2R3C (aka G4-1) downregulates IKK-beta activity; S181 phosphorylation increased in S679/682/689/692/697/701/705A mutant -MYH10 MYH10 iso2 Motility/polarity/chemotaxis; Motor P35580-2 4628 17p13.1 human K1104-ub 52485012 LKLQLAKkEEELQGA Myosin_tail_1 protein degradation 26676607 0 1 0 -CRYAB CRYAB Chaperone; Heat shock protein Q7M2W6 100519789 pig S59-p 448783 PSFLRAPsWIDTGLS intracellular localization 15878345 46 22 0 -GYS1 GYS1 Carbohydrate Metabolism - starch and sucrose; EC 2.4.1.11; Transferase P13807 2997 19q13.33 human S649-p 448239 VPPSPSLsRHSSPHQ Glycogen_syn activity, inhibited 22510711 14 15 1 -FOXM1 FOXM1 iso2 DNA-binding; Transcription factor Q08050-2 2305 12p13.33 human K341-sm 31898505 LRRNMTIkTELPLGA protein degradation transcription, inhibited 25533473 2 1 0 -Pdha1 PDHA1 Amino Acid Metabolism - valine, leucine and isoleucine biosynthesis; Carbohydrate Metabolism - butanoate; Carbohydrate Metabolism - citrate (TCA) cycle; Carbohydrate Metabolism - glycolysis and gluconeogenesis; Carbohydrate Metabolism - pyruvate; EC 1.2.4.1; Mitochondrial; Oxidoreductase P35486 18597 X F4|X 73.95 cM mouse S293-p 448258 TYRYHGHsMSDPGVS E1_dh activity, induced; acetylation; enzymatic activity, inhibited cell cycle regulation; cell differentiation, altered; carcinogenesis, altered 23290136; 25991547; 26930489; 27856638; 30429315; 30745576; 31242425; 31435015; 33826891; 34385317; 36211560 96 108 675 regulates histones acetylation -PIP5K1C PIP5K1C Carbohydrate Metabolism - inositol phosphate; EC 2.7.1.68; Kinase, lipid; Motility/polarity/chemotaxis O60331 23396 19p13.3 human Y649-p 450241 TDERSWVySPLHYSA molecular association, regulation; phosphorylation talin 1(INDUCES); AP-2 beta(INDUCES) 15738269; 16616931; 20850356 6 0 0 stimulates PIP5KG polarization -HNRNPL hnRNP L RNA splicing; RNA-binding P14866 3191 19q13.2 human S52-p 3180663 GRYYGGGsEGGRAPK carcinogenesis, altered; cell growth, altered 20972334 1 20 3 regulates the alternative splicing of caspase-9 -Sell SELL Membrane protein, integral P18337 20343 1 H2.2|1 71.37 cM mouse S364-p 40548101 RLKKGKKsQERMDDP molecular association, regulation AP1M1(DISRUPTS) 28235798 2 0 0 Abolishes interaction with AP1M1 -Eef1a1 EEF1A1 Nucleolus; Translation; Translation elongation P10126 13627 9|9 E1 mouse K165-m3 15382301 TEPPYSQkRYEEIVK GTP_EFTU molecular association, regulation translation, altered EEF1D(DISRUPTS); eEF1B(DISRUPTS); EEF1G(DISRUPTS) 28108655 1 3 3 -DDX19B DDX19B EC 3.6.4.13; Helicase; RNA-binding Q9UMR2 11269 16q22.1 human S93-p 27447125 SPLYSVKsFEELRLK molecular association, regulation; intracellular localization NUP214(DISRUPTS) 28314779 2 5 0 localization at the nuclear pore, R-loop suppression -CCNY CBCP1 Cell cycle regulation Q8ND76 219771 10p11.21 human S71-p 4750438 RASTIFLsKSQTDVR protein degradation; ubiquitination 24794231 1 2 5 -MAT2A MAT2A Amino Acid Metabolism - cysteine and methionine; EC 2.5.1.6; Other Amino Acids Metabolism - selenoamino acid; Transferase P31153 4144 2p11.2 human K340-sm 50455000 FHYGTSQkSERELLE S-AdoMet_synt_C protein stabilization; molecular association, regulation cell growth, induced; apoptosis, inhibited; transcription, induced Bcl-2(INDUCES) DNA(INDUCES) 26416353 1 0 0 -SLC3A2 SLC3A2 Membrane protein, integral; Transporter P08195 6520 11q12.3 human S406-p 6003504 LLTSSYLsDSGSTGE cell adhesion, altered 19065266 1 1 0 enhances cell- cell interactions -SQSTM1 SQSTM1 Autophagy; Nuclear receptor co-regulator; Ubiquitin conjugating system Q13501 8878 5q35.3 human T269-p 457004 GGKRSRLtPVSPESS protein degradation; molecular association, regulation; ubiquitination; intracellular localization cell cycle regulation; carcinogenesis, induced; carcinogenesis, altered; autophagy, inhibited; signaling pathway regulation mTOR(INDUCES); LC3B(DISRUPTS); Raptor(INDUCES); TRAF6(INDUCES) 20974803; 26279575; 35840557 9 74 136 -Nos1 nNOS Amino Acid Metabolism - arginine and proline; EC 1.14.13.39; Oxidoreductase P29476 24598 12q16 rat K245-ac 2459106 DLDGKSHkAPPLGGD activity, induced 18415985 1 1 0 -Klf7 KLF7 C2H2-type zinc finger protein; DNA-binding Q99JB0 93691 1|1 C2 mouse K227-ac 56423805 CQFNGCRkVYTKSSH zf-C2H2 cell cycle regulation; cell growth, inhibited; transcription, induced 26930448 1 0 0 -CAVIN1 PTRF Transcription initiation complex Q6NZI2 284119 17q21.2 human K291-ac 1873356106 AERREKLkTSRDKLR PTRF_SDPR molecular association, regulation; intracellular localization HSL(INDUCES) 28559430 1 1 0 induces lipolysis -BCAT2 BCAT2 Amino Acid Metabolism - valine, leucine and isoleucine biosynthesis; Amino Acid Metabolism - valine, leucine and isoleucine degradation; Cofactor and Vitamin Metabolism - pantothenate and CoA biosynthesis; EC 2.6.1.42; Mitochondrial; Transferase O15382 587 19q13.33 human K44-ac 11322721 LQLEMTQkPHKKPGP protein degradation 32467562 1 2 0 -GNAI1 G-alpha i1 G protein; G protein, heterotrimeric; G protein, heterotrimeric alpha G((i/o/t/z)) P63096 2770 7q21.11 human Y155-p 5688819 LNDSAAYyLNDLDRI G-alpha enzymatic activity, induced carcinogenesis, induced; signaling pathway regulation 33139573 1 1 1 -NOS3 eNOS Amino Acid Metabolism - arginine and proline; EC 1.14.13.39; Oxidoreductase P29474 4846 7q36.1 human Y81-p 456466 WEVGSITyDTLSAQA enzymatic activity, induced 32653904 5 2 0 -RIPK3 RIPK3 EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, Ser/Thr (non-receptor); Protein kinase, TKL Q9Y572 11035 14q12 human S164-p 27928503 KLADFGLsTFQGGSQ Pkinase enzymatic activity, inhibited; phosphorylation 35739084 3 2 0 inhibits MLKL phosphorylation and necroptosis -OSMR OSMR Membrane protein, integral; Receptor, cytokine Q99650 9180 5p13.1 human Y839-p 475364 LTKPNYLyLLPTEKN phosphorylation 18430728 2 1 7 important for STAT5B activation -IFNAR1 IFNAR1 Membrane protein, integral; Receptor, cytokine P17181 3454 21q22.11 human S539-p 52427502 SQDSGNYsNEDESES protein degradation; ubiquitination 26676772 1 0 0 -Rab9a RAB9A G protein; G protein, monomeric; G protein, monomeric, Rab Q9R0M6 56382 X|X F5 mouse S179-p 3191548 ILATEDRsEHLIQTD molecular association, regulation; intracellular localization; phosphorylation autophagy, induced; signaling pathway regulation RIPK1(INDUCES) 30511961; 35018428 2 13 0 -CEBPB C/EBP-beta DNA-binding; Motility/polarity/chemotaxis; Transcription factor P17676 1051 20q13.13 human S223-p 2902801 VPSGSSGsLSTSSSS protein conformation 22080951 2 2 0 -TRIM32 TRIM32 EC 6.3.2.-; EC 6.3.2.19; Ligase; UBIQUITIN LIGASE; Ubiquitin conjugating system; Ubiquitin ligase Q13049 22954 9q33.1 human S328-p 2049721 TFREMDMsPEEVVAS intracellular localization cell growth, inhibited 25100564 2 13 0 promotes Asymmetric Cell Division -KCNA5 Kv1.5 Channel, potassium; Membrane protein, integral; Membrane protein, multi-pass P22460 3741 12p13.32 human K221-sm 3144800 REDEGFIkEEEKPLP activity, induced 17261810 1 0 0 -EGFR EGFR EC 2.7.10.1; KINASE; Kinase, protein; Membrane protein, integral; Oncoprotein; Protein kinase, TK; Protein kinase, tyrosine (receptor) P00533 1956 7p11.2 human T430-p 1876620106 LEIIRGRtKQHGQFS Recep_L_domain enzymatic activity, inhibited carcinogenesis, inhibited; cell growth, inhibited 35226996 1 0 0 -NOS3 eNOS Amino Acid Metabolism - arginine and proline; EC 1.14.13.39; Oxidoreductase P29473 287024 cow T1177-p 467803 EVTSRIRtQSFSLQE phosphorylation; enzymatic activity, induced 16980435 2 11 8 stimulates VASP S236 phosphorylation in the presence of angiotensin 2 (AngII) -CDC37 CDC37 Chaperone Q16543 11140 19p13.2 human Y298-p 451691 GLDPVEVyESLPEEL CDC37_C molecular association, regulation CDK4(DISRUPTS); RAF1(DISRUPTS) 22727666 1 3 143 -Tbx21 TBX21 DNA-binding; Transcription factor Q9JKD8 57765 11|11 D mouse T302-p 27930807 ETQFIAVtAYQNAEI T-box transcription, inhibited 23616576 1 0 0 suppresses NFAT1 expression, critical for inhibition of NFAT1-mediated IL-2 and Th2 cytokine production -GHR GH receptor Membrane protein, integral; Receptor, cytokine P19941 100009325 rabbit Y627-p 486258 EFLSSCGyVSTDQLN molecular association, regulation STAT5A(INDUCES); STAT5B(INDUCES) 17666591 3 0 0 -Dnajb4 DNAJB4 Chaperone Q9D832 67035 3|3 H3 mouse Y172-p 450786 KVSLEEIySGCTKRM DnaJ_C molecular association, regulation carcinogenesis, inhibited Src iso1(INDUCES) 27065329 1 14 471 complex suppressing cancer invasion -Pde4d PDE4D EC 3.1.4.53; Nucleotide Metabolism - purine; Phosphodiesterase Q01063 238871 13 D2.1|13 59.69 cM mouse S141-p 483645 SDSDYDLsPKSMSRN phosphorylation; enzymatic activity, induced 25918234 1 28 5 regulates CAMP concentration and insulin secretion, regulates phosphorylation of CRTCs -Otud5 OTUD5 DEUBIQUITINASE; EC 3.4.19.12; Protease; Ubiquitin-specific protease Q3U2S4 54644 X A1.1|X 3.54 cM mouse S332-p 1870773110 HRNIHYNsVVNPNKA OTU protein degradation; protein stabilization; molecular association, regulation; ubiquitination; phosphorylation; enzymatic activity, induced cell cycle regulation; cell growth, induced; autophagy, inhibited; transcription, altered; signaling pathway regulation BTRC(DISRUPTS) 33110214 1 1 0 inhibits ubiquitination and induces stabilization of OTUD5 and BTRCP1 further causing DEPTOR degradation, regulates phosphorylation of mTOR targets, promotes OTUD5-?TrCP1-DEPTOR pathway -OGG1 OGG1 DNA repair, damage; Deoxyribonuclease; EC 4.2.99.18; Lyase O15527 4968 3p25.3 human S326-p 10036103 FSADLRQsRHAQEPP enzymatic activity, inhibited 19674107 1 0 0 -CXCR4 CXCR4 GPCR, family 1; Membrane protein, integral; Membrane protein, multi-pass; Receptor, GPCR P61073 7852 2q22.1 human Y157-p 455337 LLAEKVVyVGVWIPA 7tm_1; TM phosphorylation transcription, altered 15615703 1 0 0 -CCND1 CCND1 Activator; Cell cycle regulation; Nuclear receptor co-regulator; Oncoprotein P24385 595 11q13.3 human T286-p 447839 EEVDLACtPTDVRDV protein degradation; molecular association, regulation; ubiquitination; intracellular localization cell cycle regulation; carcinogenesis, inhibited; cell growth, induced; apoptosis, induced; cell growth, inhibited; cell growth, altered AMBRA1(INDUCES); BTRC(INDUCES); CDK2(DISRUPTS); WDR77(DISRUPTS); FBXO31(INDUCES); CDK4(DISRUPTS); SMARCA4(DISRUPTS); Exportin-1(INDUCES); CRYAB(INDUCES); PRMT5(DISRUPTS) 10766840; 11751903; 15735756; 16153639; 16504004; 16732330; 17046823; 17081987; 18650423; 19412162; 19767775; 20951943; 24119401; 33521925; 33854232; 33854239; 36106050; 37301510 35 5 1 -NFATC1 NFAT2 DNA-binding; Transcription factor O95644 4772 18q23 human T339-p 1869090805 PVKSRKTtLEQPPSV activity, induced carcinogenesis, induced; cell motility, induced; transcription, induced 31730483 1 0 0 multiple sites mutatnt -SCN8A SCN8A Channel, sodium; Membrane protein, integral; Membrane protein, multi-pass Q9UQD0 6334 12q13.13 human S641-p 1869659202 RRSVKRNsTVDCNGV Na_trans_cytopl activity, inhibited neural plasticity 32611770 1 1 0 Regulates voltage-gated sodium channel Nav1.6 activity and neuronal excitability -DNMT1 DNMT1 iso2 Amino Acid Metabolism - cysteine and methionine; Cell development/differentiation; EC 2.1.1.37; METHYLTRANSFERASE; Methyltransferase; Methyltransferase, DNA; Transcription regulation P26358-2 1786 19p13.2 human S730-p 452655 DNIPEMPsPKKMHQG molecular association, regulation; protein conformation; activity, inhibited RBBP7(INDUCES) 28143904 4 69 10 -Pag1 PAG Adaptor/scaffold; Membrane protein, integral Q9JM80 64019 2q23 rat Y314-p 450659 EEEISAMySSVNKPG PAG molecular association, regulation; intracellular localization cell cycle regulation; cell differentiation, altered; cytoskeletal reorganization; cell adhesion, altered SOCS1(NOT_REPORTED); CTK(INDUCES); CSK(INDUCES); CSK(NOT_REPORTED); SOCS1(INDUCES) 10801129; 10918051; 16920712; 19124084 9 31 643 -INSR INSR EC 2.7.10.1; KINASE; Kinase, protein; Membrane protein, integral; Protein kinase, TK; Protein kinase, tyrosine (receptor) P06213 3643 19p13.2 human Y1355-p 447683 SLGFKRSyEEHIPYT protein conformation; enzymatic activity, induced cell cycle regulation; cell growth, altered 10805733; 10852715; 10940390; 1618780; 1654097 15 5 2 antibodies against Y1355 and Y1361 peptides stimulated cell proliferation. ; decreases ERK activation; regulates cell proliferation in response to insulin but not IGF-1 on pp120 -H4C1 H4 DNA-binding P62805 8359 6p22.2 human K77-ac 3607639 VTYTEHAkRKTVTAM CENP-T_C molecular association, regulation polybromo 1(INDUCES) 20368734 1 5 95 varying site specificity binding for each bromodomain 1-6 -Yy1 YY1 C2H2-type zinc finger protein; Cell development/differentiation; Transcription factor Q00899 22632 12 F1|12 59.58 cM mouse S120-p 460025 EVVGGDDsDGLRAED molecular association, regulation RNA(INDUCES); RNA(DISRUPTS) 28834756 3 34 0 -LRP1 LRP1 Cell surface; Membrane protein, integral; Motility/polarity/chemotaxis; Receptor, misc. Q07954 4035 12q13.3 human Y4473-p 473712 VEIGNPTyKMYEGGE molecular association, regulation SNX17(DISRUPTS); SHP-2(INDUCES) 18381291 4 3 2 -Pdha1 PDHA1 Amino Acid Metabolism - valine, leucine and isoleucine biosynthesis; Carbohydrate Metabolism - butanoate; Carbohydrate Metabolism - citrate (TCA) cycle; Carbohydrate Metabolism - glycolysis and gluconeogenesis; Carbohydrate Metabolism - pyruvate; EC 1.2.4.1; Mitochondrial; Oxidoreductase P26284 29554 Xq14 rat S293-p 448258 TYRYHGHsMSDPGVS E1_dh acetylation; enzymatic activity, altered 34360775 96 108 675 regulates acetylation of brain proteins -TERF1 TRF1 DNA-binding P54274 7013 8q21.11 human S435-p 3192037 KKLKLISsDSED___ apoptosis, induced DNA(INDUCES) 18625707 1 5 0 enhances binding of TRF1 to telomeric DNA in vivo and in vitro; regulated by phosphorylation of sites T344 and T371 by Cdc2 -Itch ITCH EC 6.3.2.-; EC 6.3.2.19; Ligase; UBIQUITIN LIGASE; Ubiquitin conjugating system; Ubiquitin ligase Q8C863 16396 2 H1|2 76.94 cM mouse S199-p 459622 KRANGNNsPSLSNGG activity, induced; protein stabilization; protein conformation 16446428 1 6 0 -ERBB4 HER4 EC 2.7.10.1; KINASE; Kinase, protein; Membrane protein, integral; Protein kinase, TK; Protein kinase, tyrosine (receptor) Q15303 2066 2q34 human Y984-p 34494908 MARDPQRyLVIQGDD molecular association, regulation STAT5A(INDUCES); SHP-2(INDUCES) 16729043 1 0 0 -Irs1 IRS1 Adaptor/scaffold; Motility/polarity/chemotaxis P35570 25467 9q34 rat S422-p 40511593 PSDGGFIsSDEYGSS protein degradation; molecular association, regulation; ubiquitination; phosphorylation cell growth, inhibited; apoptosis, induced; signaling pathway regulation BTRC(INDUCES) 30240640 1 2 0 inhibits phosphorylation of Akt and FOXO1/3a, PI3K/Akt pathway -Sstr2 SSTR2 GPCR, family 1; Membrane protein, integral; Membrane protein, multi-pass; Receptor, GPCR P30680 rat T359-p 12577700 ETTETQRtLLNGDLQ activity, induced; intracellular localization; receptor internalization, altered signaling pathway regulation 20051480; 21795688 6 0 0 Dephosphorylation is initiated directly after receptor activation at or near the plasma membrane; leads to disruption of the ?-arrestin- GPCR complex -LRRK2 LRRK2 EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, Ser/Thr (non-receptor); Protein kinase, TKL Q5S007 120892 12q12 human S2032-p 3306338 CRMGIKTsEGTPGFR Pkinase enzymatic activity, induced 20595391 5 2 0 -ACLY ACLY Carbohydrate Metabolism - citrate (TCA) cycle; EC 2.3.3.8; Lyase; Transferase P53396 47 17q21.2 human Y252-p 462909 EAYPEEAyIADLDAK Citrate_bind acetylation; enzymatic activity, induced carcinogenesis, induced 32420483 1 1 1 -Grin1 NMDAR1 Channel, calcium; Channel, ligand-gated; Membrane protein, integral; Membrane protein, multi-pass P35438 14810 2 A3|2 17.14 cM mouse S896-p 448255 SSFKRRRsSKDTSTG neural plasticity 34666797 24 0 0 -Nos1 nNOS Amino Acid Metabolism - arginine and proline; EC 1.14.13.39; Oxidoreductase P29476 24598 12q16 rat S741-p 452159 LAEAVKFsAKLMGQA enzymatic activity, inhibited 15251453 1 0 0 -STAT5B STAT5B DNA-binding; Oncoprotein; Transcription factor P51692 6777 17q21.2 human Y725-p 448734 AGGGSATyMDQAPSP transcription, induced 16772534 3 0 1 -NFKB1 NFkB-p105 iso2 DNA-binding; Transcription factor P19838-2 4790 4q24 human Y90-p 1880539210 PQVKICNyVGPAKVI molecular association, regulation transcription, altered DNA(INDUCES) 36534507 1 0 0 -RACK1 RACK1 Adaptor/scaffold; G protein; G protein, heterotrimeric; G protein, heterotrimeric beta; Motility/polarity/chemotaxis; Nuclear receptor co-regulator P63244 10399 5q35.3 human Y246-p 451481 LCFSPNRyWLCAATG WD40 protein stabilization; molecular association, regulation; ubiquitination; intracellular localization; activity, inhibited; phosphorylation translation, altered; carcinogenesis, inhibited; cell adhesion, induced; cell motility, altered; cell motility, inhibited; transcription, inhibited; endocytosis, inhibited ZBP1(INDUCES); Src(INDUCES); Src(NOT_REPORTED) 12400005; 16849317; 17574549; 21685945; 22523568 6 1 1 Release of beta-actin mRNA; decreases phosphorylation of E-cadherin, B-catenin, p120 catenin and actin and localises them to cell-to-cell contacts, prevents ubiquitination of E-cadherin further inducing its stabilization, inhibits E-cadherin endocytosis -Papola PAP-alpha EC 2.7.7.19; RNA processing; RNA splicing; Transferase Q61183 18789 12|12 E mouse S537-p 1737605 DNSMSVPsPTSAMKT enzymatic activity, induced 18084034 1 5 0 in vitro and in vivo -FANCE FANCE DNA repair, damage Q9HB96 2178 6p21.31 human T346-p 476781 LGLLRLCtWLLALSP FA_FANCE protein degradation; molecular association, regulation; intracellular localization FANCD2(INDUCES) 17296736 2 0 0 required for mitomycin C resistance -ITGAL ITGAL Cell adhesion; Cell surface; Membrane protein, integral; Motility/polarity/chemotaxis P20701 3683 16p11.2 human S1165-p 2887600 LHEKDSEsGGGKD__ activity, induced; molecular association, regulation; intracellular localization; phosphorylation cell motility, induced; cell adhesion, induced; cytoskeletal reorganization; cell adhesion, altered 14-3-3 beta(INDUCES); FLNA(DISRUPTS); ICAM1(INDUCES); ACTN1(INDUCES); talin 1(INDUCES) 16301335; 29903913 2 1 0 induces phosphorylation of T758 of ITGB2, regulates localization of alpha actinin -Cdc37 CDC37 Chaperone Q63692 114562 8q13 rat S13-p 450034 VWDHIEVsDDEDETH CDC37_N molecular association, regulation; intracellular localization ICK(INDUCES); MOK(INDUCES); Src(INDUCES); MAK(INDUCES); CDK4(INDUCES); Akt1(INDUCES); RAF1(INDUCES); AurB(INDUCES) 15082798; 17922836 13 29 0 S13 phosphorylated Cdc37 colocalized with HSP90 in membrane ruffles and is associated with HSP90 kinase complexes. -Ncoa3 SRC-3 ACETYLTRANSFERASE; Acetyltransferase; EC 2.3.1.48; Motility/polarity/chemotaxis; Nuclear receptor co-regulator; Transcription, coactivator/corepressor O09000 17979 2|2 H3 mouse R844-me 2363407 SVRPPYNrAVSLDSP protein degradation transcription, inhibited CBP(INDUCES) 17043108 1 0 0 -NFE2L2 NRF2 DNA-binding; Transcription factor Q16236 4780 2q31.2 human S577-p 10292702 DEDGKPYsPSEYSLQ molecular association, regulation; intracellular localization transcription, induced PIN1(INDUCES) 19668370; 34918396 2 2 0 moderate effects observed only in NFE2L2-5A mutant -Bcl2l11 BIM Apoptosis O88498 64547 3q36 rat S109-p 449069 APMSCDKsTQTPSPP apoptosis, induced 12388545 1 1 0 -Marcks MARCKS Actin-binding; Motility/polarity/chemotaxis P26645 17118 10 B1|10 19.49 cM mouse S152-p 447786 KKKKKRFsFKKSFKL MARCKS receptor internalization, induced; intracellular localization carcinogenesis, induced; cell motility, altered 20211725; 34556581 26 15 10 -GRIN2A NMDAR2A Channel, ligand-gated; Membrane protein, integral; Membrane protein, multi-pass Q12879 2903 16p13.2 human S1459-p 481117 RVYKKMPsIESDV__ NMDAR2_C molecular association, regulation; receptor recycling, induced neural plasticity SNX27(INDUCES); PSD-95(DISRUPTS) 32877683; 34233182 2 8 2 -Arrb2 ARRB2 Adaptor/scaffold Q91YI4 216869 11 B3|11 42.99 cM mouse K108-ub 6140807 LQDRLLKkLGQHAHP Arrestin_N molecular association, regulation mAChR M2(INDUCES); mAChR m1(INDUCES) 19055777 1 1 0 -MAP1LC3C LC3C Autophagy; Microtubule-binding; Ubiquitin-like modifier; Vesicle Q9BXW4 440738 1q43 human S93-p 1869546300 YLLVNNKsLVSMSAT ATG8 molecular association, regulation apoptosis, induced ATG4B(DISRUPTS) 31709703 1 1 0 ; including ATG4A, ATG4C, ATG4D -HMGA1 HMGA1 iso2 DNA-binding P17096-2 3159 6p21.31 human K60-ac 458953 SKNKGAAkTRKTTTT apoptosis, induced 11389094 4 2 0 -OGT OGT EC 2.4.1.255; Glycan Metabolism - O-glycan biosynthesis; O-GlcNAc TRANSFERASE; Transferase O15294 8473 Xq13.1 human S4-p 27713501 ____MASsVGNVADS enzymatic activity, induced 23395175 1 1 0 -Cgas cGAS EC 2.7.7.86 Q8C6L5 214763 9|9 E1 mouse K382-sm 62952701 LNNHGIEkTCCESSG enzymatic activity, inhibited transcription, inhibited; signaling pathway regulation DNA(DISRUPTS) 28095500 1 0 0 regulation of STING signaling pathway -ECT2 ECT2 iso2 GEF; GEF, Rac/Rho; Motility/polarity/chemotaxis Q9H8V3-2 1894 3q26.31 human T327-p 483847 YLYEKANtPELKKSV molecular association, regulation cytoskeletal reorganization PLK1(INDUCES); RHOA(INDUCES) 28692064 2 18 8 cytoskeletal rearrangements during interphase -IGF1R IGF1R EC 2.7.10.1; KINASE; Kinase, protein; Membrane protein, integral; Protein kinase, TK; Protein kinase, tyrosine (receptor) P08069 3480 15q26.3 human K1130-sm 12723517 MAYLNANkFVHRDLA PK_Tyr_Ser-Thr intracellular localization cell growth, induced; transcription, induced DNA(INDUCES) 20145208; 25448401 2 0 0 -CD33 CD33 Cell adhesion; Membrane protein, integral P20138 945 19q13.41 human Y358-p 450953 SKDTSTEySEVRTQ_ molecular association, regulation SHP-2(INDUCES) 10887109 2 0 3 While tyrosine phosphorylation of CD33 was shown to induce its interaction in cells with SHP-1 and SHP-2, the specific contribution of Y358 phosphorylation to CD33 interaction with SHP-2 was based on in vitro binding experiments. -RB1 Rb Nuclear receptor co-regulator; Oncoprotein; Transcription, coactivator/corepressor; Tumor suppressor P06400 5925 13q14.2 human S567-p 450021 SLAWLSDsPLFDLIK RB_A protein degradation; molecular association, regulation; activity, inhibited cell growth, induced; apoptosis, induced; apoptosis, inhibited MDM2(INDUCES) 12646568; 20871633; 22279936; 31163228 6 0 0 dephosphorylation of Rb induced cell death -TNKS TNKS EC 2.4.2.30; Transferase O95271 8658 8p23.1 human T839-p 21326702 DTQGRNStPLHLAAG Ank_4 protein stabilization; intracellular localization; enzymatic activity, induced cell cycle regulation; cell growth, induced 21818122 1 0 0 -Csf3r GCSFR Membrane protein, integral; Receptor, cytokine P40223 12986 4 D2.2|4 59.77 cM mouse Y753-p 451834 RTGDQVLyGQVLESP activity, induced 7489718 5 0 0 Receptors mutant for Y728 or Y753 could neither transduce growth-inhibitory signals nor induce the neutrophil-specific myeloperoxidase (MPO) gene. -NFATC1 NFAT2 DNA-binding; Transcription factor O95644 4772 18q23 human K702-sm 6413902 PANVPIIkTEPTDDY molecular association, regulation; intracellular localization chromatin organization, altered; signaling pathway regulation; transcription, inhibited HDAC1(INDUCES); HDAC2(INDUCES); PML(INDUCES); HDAC4(INDUCES) 19218564; 32986812 2 1 0 K702/914R and K349/702/914R mutants prevented sumoylation in mice, increased IL-2 secretion counteracted IL-17 and IFN-gamma expression -DOK1 DOK1 Adaptor/scaffold; Motility/polarity/chemotaxis Q99704 1796 2p13.1 human Y315-p 448904 CPSQDSLySDPLDST molecular association, regulation RASA1(INDUCES) 10688886 1 26 331 -CTDP1 CTDP1 EC 3.1.3.16; Motility/polarity/chemotaxis; PHOSPHATASE; Protein phosphatase, Ser/Thr (non-receptor); Transcription initiation complex Q9Y5B0 9150 18q23 human S944-p 455467 NEDEGSSsEADEMAK FCP1_C molecular association, regulation; enzymatic activity, induced transcription, altered GTF2F1(INDUCES) 15723518; 19215094 2 0 1 -CPSF3 CPSF3 EC 3.1.27.-; RNA processing; RNA splicing; RNA-binding; Ribonuclease Q9UKF6 51692 2p25.1 human K462-sm 2586339 TLNFRGEkLAKVMGF RNA splicing, altered; cell growth, induced 17923699 1 0 0 regulation of mRNA 3'-end processing- cleavage and polyadenylation -Dpysl2 CRMP-2 Microtubule-binding; Motility/polarity/chemotaxis P47942 25416 15p12 rat T555-p 448084 DNIPRRTtQRIVAPP activity, inhibited cell growth, inhibited 16595691; 26804001 19 2 8 -PPP1R14A PPP1R14A Inhibitor; Protein phosphatase, regulatory subunit BAA22995 397610 pig T38-p 449098 QKRHARVtVKYDRRE PP1_inhibitor activity, induced; protein conformation 11517233; 18073109 29 0 0 -JAK3 JAK3 EC 2.7.10.2; KINASE; Kinase, protein; Protein kinase, TK; Protein kinase, tyrosine (non-receptor) P52333 3718 19p13.11 human Y980-p 447636 LLPLDKDyYVVREPG PK_Tyr_Ser-Thr enzymatic activity, induced 9391116 9 4 2 -DCTN6 dynactin 6 Motility/polarity/chemotaxis O00399 10671 8p12 human T186-p 27933603 KTMKGSStPVKN___ molecular association, regulation; intracellular localization cell cycle regulation PLK1(INDUCES) 23455152 1 0 0 Dynactin 6 targets PLK1 to mitotic kinetochores. -Cebpa C/EBP-alpha DNA-binding; Transcription factor P05554 24252 1q21 rat K326-ac 56394106 SDNDRLRkRVEQLSR bZIP_2 molecular association, regulation autophagy, induced beclin 1(INDUCES) 34217716 2 0 0 -Myc Myc DNA-binding; Nucleolus; Oncoprotein; Transcription factor P01108 17869 15 D1|15 26.19 cM mouse K338-ac 458888 RKDYPAAkRAKLDSG Myc_N activity, induced; protein stabilization cell growth, induced; cell differentiation, induced; transcription, induced 15572685; 26655722 7 4 5 -IRS2 IRS2 Adaptor/scaffold; Motility/polarity/chemotaxis Q9Y4H2 8660 13q34 human S391-p 1984215 SVAGSPLsPGPVRAP activity, inhibited 34731634 3 39 80 -FOXO1 FOXO1A DNA-binding; Nuclear receptor co-regulator; Oncoprotein; Transcription factor Q12778 2308 13q14.11 human K222-ac 15625101 HNLSLHSkFIRVQNE Forkhead intracellular localization; phosphorylation 20519497 1 0 1 -EYA3 EYA3 EC 3.1.3.48; PHOSPHATASE; Protein phosphatase, tyrosine (non-receptor) Q99504 2140 1p35.3 human Y237-p 1870640400 TTLAATTyQSEKPSV cell growth, altered 31847183 1 0 0 -Irs1 IRS1 Adaptor/scaffold; Motility/polarity/chemotaxis P35570 25467 9q34 rat Y1222-p 448699 SSEDLSTyASINFQK molecular association, regulation SHP-2(INDUCES) 7588273 2 2 0 -Slc14a2 SLC14A2 Membrane protein, integral; Membrane protein, multi-pass; Transporter; Transporter, SLC family Q62668 54302 18q12.3 rat S486-p 2813501 TVFPRRKsVFHIEWS activity, induced; molecular association, regulation; intracellular localization SNAPIN(INDUCES) 18495802; 20071460; 20457831; 22205230; 25377918 10 2 3 apical plasma membrane accumulation -KCNQ2 Kv7.2 Channel, potassium; Membrane protein, integral; Membrane protein, multi-pass O43526 3785 20q13.33 human S52-p 12526300 SEAPKRGsILSKPRA activity, induced 9872318 2 4 2 -Fmr1 FMR1 Nucleolus; RNA-binding; Translation P35922 14265 X A7.1|X 34.83 cM mouse R543-me 4046000 GGRGQGGrGRGGGFK FXMRP1_C_core molecular association, regulation RNA(DISRUPTS) 20064924 4 0 0 methylation inhibits sc1 RNA binding; R533 and R538 determine association with polyribosomes; methylation doesnot inhibit AATYK mRNA association; different RNAs have distinct molecular requirements for binding to FMR1 -GATA4 GATA4 Motility/polarity/chemotaxis; Transcription factor P43694 2626 8p23.1 human K329-ac 1877203101 PKNLNKSkTPAAPSG apoptosis, inhibited; transcription, induced 32239217 1 0 0 -EP300 p300 ACETYLTRANSFERASE; Acetyltransferase; EC 2.3.1.48; Motility/polarity/chemotaxis; Nuclear receptor co-regulator; Transcription, coactivator/corepressor Q09472 2033 22q13.2 human S2366-p 486264 MEQGHFAsPDQNSML molecular association, regulation; enzymatic activity, induced transcription, altered SP1(NOT_REPORTED) 17623675 2 0 0 controls EGF-induced keratin 16 promoter activity ; regulates HAT activity of p300 -OSBP OSBP Lipid-binding P16258 rabbit S192-p 452647 AVKMLAEsDESGDEE molecular association, regulation; intracellular localization VAPA(INDUCES) 22875984 1 73 12 regulation of Sphingomyelin synthesis. S381A/S3D mutant has enhanced binding and altered localization -POLH POLH DNA repair, damage; EC 2.7.7.7; Transferase Q9Y253 5429 6p21.1 human K311-sm 1877365917 GIEHDPVkPRQLPKT intracellular localization; enzymatic activity, inhibited 32350109 1 1 0 -TELO2 TELO2 Adaptor/scaffold Q9Y4R8 9894 16p13.3 human S485-p 27530803 PQAQLAGsDSDLDSD protein degradation; molecular association, regulation; ubiquitination; intracellular localization signaling pathway regulation FBXO9(INDUCES) 23263282 1 1 0 mediates mTORC1 signaling -SMAD4 SMAD4 DNA-binding; Nuclear receptor co-regulator; Transcription, coactivator/corepressor Q13485 4089 18q21.2 human K507-ub 18898600 ILRMSFVkGWGPDYP MH2 molecular association, regulation transcription, induced; signaling pathway regulation SMAD3(INDUCES) 12794086 1 1 0 ubiquitin-assisted oligomerization with Smad3; regulation of TGF-beta signaling -SCN5A SCN5A Channel, sodium; Membrane protein, integral; Membrane protein, multi-pass Q14524 6331 3p22.2 human T101-p 1867858201 IVLNKGKtIFRFSAT protein degradation; molecular association, regulation endocytosis, altered; autophagy, induced LC3B(INDUCES) 30759345 1 0 0 -CCND3 CCND3 Activator; Cell cycle regulation; Nuclear receptor co-regulator P30281 896 6p21.1 human T283-p 452160 QGPSQTStPTDVTAI protein degradation; molecular association, regulation; ubiquitination; intracellular localization; phosphorylation cell cycle regulation; carcinogenesis, inhibited; carcinogenesis, altered; apoptosis, induced; cell growth, inhibited FBXL8(INDUCES) 15252116; 15326477; 16331257; 22885699; 33122824; 34103301 8 4 5 increases Rb phosphorylation in tissues from CCND3 wt and CCND3 T283A AML patients -AKT1 Akt1 EC 2.7.11.1; KINASE; Kinase, protein; Oncoprotein; Protein kinase, AGC; Protein kinase, Ser/Thr (non-receptor) P31749 207 14q32.33 human S246-p 460649 LSRERVFsEDRARFY Pkinase enzymatic activity, induced apoptosis, inhibited 16549426 1 0 0 doxorubicin-induced apoptosis -SOX2 SOX2 Cell development/differentiation; DNA-binding; Transcription factor P48431 6657 3q26.33 human K245-sm 12004415 GSMGSVVkSEASSSP transcription, inhibited 23515309 3 0 0 -Mef2c MEF2C DNA-binding; Transcription factor Q8CFN5 17260 13 C3|13 43.68 cM mouse S396-p 456980 SIKSEPVsPPRDRTT molecular association, regulation PIN1(INDUCES) 20801874 3 9 0 Pin1 binding decreases MEF2C stability and its transcriptional activity -Etv4 ETV4 DNA-binding P28322 18612 11 D|11 65.48 cM mouse K6-ac 26373304 __MERRMkGGYLDQR ETS_PEA3_N sumoylation transcription, induced 21543453 1 1 0 acetylated sites inhibits sumoylation reciprocally -PPP1R12A MYPT1 Motility/polarity/chemotaxis; PHOSPHATASE; Protein phosphatase, regulatory subunit O14974 4659 12q21.2-q21.31 human T853-p 452075 PREKRRStGVSFWTQ enzymatic activity, inhibited; phosphorylation cell motility, induced; cell growth, inhibited; cell differentiation, induced; cell adhesion, induced; cytoskeletal reorganization; signaling pathway regulation 31834925; 33802280; 35594862; 37064875 44 2 17 -CD37 CD37 Membrane protein, integral; Membrane protein, multi-pass P11049 951 19q13.33 human Y274-p 7788473 CRNLDHVyNRLARYR apoptosis, inhibited; signaling pathway regulation 22624718 1 2 22 -TBXA2R TXA2-R iso2 GPCR, family 1; Membrane protein, integral; Membrane protein, multi-pass; Receptor, GPCR P21731-2 6915 19p13.3 human S357-p 469629 RLPGSSDsRASASRA molecular association, regulation; receptor desensitization, altered; receptor internalization, altered ARRB2(INDUCES) 16956790 1 0 0 -FBXL19 FBXL19 UBIQUITIN LIGASE; Ubiquitin ligase Q6PCT2 54620 16p11.2 human K240-ub 1881559701 GRERHLKkVGGDACL protein degradation cell motility, induced 33053230 1 0 0 increasing Rac1 stability -VCL Vinculin iso2 Cell adhesion; Cytoskeletal; Motility/polarity/chemotaxis P18206-2 7414 10q22.2 human Y100-p 454004 QMLQSDPySVPARDY Vinculin molecular association, regulation cytoskeletal reorganization; cell adhesion, altered BSG(INDUCES) 25033086 4 3 53 -IGF1R IGF1R EC 2.7.10.1; KINASE; Kinase, protein; Membrane protein, integral; Protein kinase, TK; Protein kinase, tyrosine (receptor) P08069 3480 15q26.3 human S1321-p 25240303 LPLPDRHsGHKAENG receptor internalization, induced; protein degradation; molecular association, regulation; phosphorylation signaling pathway regulation ARRB1(INDUCES) 22509025 1 0 0 S1278 induces transient association, while S1321 induces more stable association; Akt phosphorylation, regulates ERK/Akt signaling pathway -MTOR mTOR Autophagy; EC 2.7.11.1; KINASE; Kinase, protein; Motility/polarity/chemotaxis; Protein kinase, Ser/Thr (non-receptor); Protein kinase, atypical P42345 2475 1p36.22 human T2164-p 20473600 APSLQVItSKQRPRK molecular association, regulation; phosphorylation cell cycle regulation; cell growth, induced; signaling pathway regulation Raptor(DISRUPTS) 21576368 1 1 0 phosphorylation increases the sensitivity and duration of insulin-stimulated mTORC1 signaling; Increased phosphorylation of itself at S2481 and of S6K1 and 4EBP1 -Pdgfrb PDGFRB EC 2.7.10.1; KINASE; Kinase, protein; Membrane protein, integral; Oncoprotein; Protein kinase, TK; Protein kinase, tyrosine (receptor) Q05030 rat Y750-p 447508 SKDESVDyVPMLDMK PK_Tyr_Ser-Thr molecular association, regulation; enzymatic activity, induced cell cycle regulation; cell growth, induced; signaling pathway regulation NCK1(INDUCES) 23181695; 23776396 26 4 6 downstream signaling pathway phosphorylation of STAT3, ERK1/2, Akt, and PLCG1 was determined in PDGF-stimulated VSMCs -PDHA1 PDHA1 Amino Acid Metabolism - valine, leucine and isoleucine biosynthesis; Carbohydrate Metabolism - butanoate; Carbohydrate Metabolism - citrate (TCA) cycle; Carbohydrate Metabolism - glycolysis and gluconeogenesis; Carbohydrate Metabolism - pyruvate; EC 1.2.4.1; Mitochondrial; Oxidoreductase P08559 5160 Xp22.12 human Y289-p 454752 MELQTYRyHGHSMSD E1_dh enzymatic activity, inhibited carcinogenesis, induced 26848621 1 28 437 essential for Src?s metabolic and pro-malignant effects -BRCA1 BRCA1 EC 6.3.2.-; Nuclear receptor co-regulator; Transcription, coactivator/corepressor; Tumor suppressor; UBIQUITIN LIGASE; Ubiquitin conjugating system; Ubiquitin ligase P38398 672 17q21.31 human S1189-p 450007 QKGELSRsPSPFTHT molecular association, regulation; intracellular localization cell growth, induced ATM(INDUCES) 10550055; 19683496; 21706030 6 15 6 -MYC Myc DNA-binding; Nucleolus; Oncoprotein; Transcription factor P01106 4609 8q24.21 human S82-p 4967400 PLSPSRRsGLCSPSY Myc_N protein degradation; protein stabilization; ubiquitination; phosphorylation cell growth, induced; apoptosis, inhibited; transcription, induced; transcription, inhibited 22025562; 33461590; 36513627 4 6 1 -VCP VCP Chaperone; DNA repair, damage; EC 3.6.4.6; Endoplasmic reticulum; Hydrolase P55072 7415 9p13.3 human S748-p 457558 RFARRSVsDNDIRKY Vps4_C apoptosis, inhibited 16551632 2 9 1 -Nphs1 NPHS1 Cell adhesion; Immunoglobulin superfamily; Membrane protein, integral Q9R044 64563 1q21 rat Y1204-p 469565 PGAWGPLyDEVRMDP molecular association, regulation; phosphorylation cytoskeletal reorganization NCK1(NOT_REPORTED); PLCE1(INDUCES) 16934223; 18256598; 19179337; 22013520 16 1 0 -Hipk2 HIPK2 EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, CMGC; Protein kinase, Ser/Thr (non-receptor) Q9QZR5 15258 6|6 B1 mouse Y361-p 449571 SKAVCSTyLQSRYYR Pkinase intracellular localization; phosphorylation 23485397 6 78 3324 induces phosphorylation of HIPK2 substrates, inhibits HIPK2 aggresome accumulation -STMN2 STMN2 Cytoskeletal Q93045 11075 8q21.13 human S50-p 455606 KQINKRAsGQAFELI Stathmin carcinogenesis, induced; cell motility, induced; cytoskeletal reorganization 23893240 5 5 0 -SNAI1 Snail1 C2H2-type zinc finger protein; Transcription factor O95863 6615 20q13.13 human S107-p 455882 SQPPSPPsPAPSSFS protein degradation; protein stabilization; molecular association, regulation; phosphorylation; enzymatic activity, induced; activity, induced; ubiquitination; intracellular localization carcinogenesis, induced; cell motility, induced; cell motility, altered; transcription, induced; signaling pathway regulation; transcription, altered GSK3B(DISRUPTS) 15448698; 15647282; 19004823; 19923321; 20305697; 31209060 6 1 0 EGF signaling pathway; inhibits degradation of protein by supressing ubiquitination and inhibits the phosphorylation of S104 -Cyp1a1 CYP1A1 Amino Acid Metabolism - tryptophan; Cofactor and Vitamin Metabolism - retinol; EC 1.14.14.1; Oxidoreductase; Xenobiotic Metabolism - metabolism by cytochrome P450 P00184 13076 9 B|9 31.34 cM mouse T35-p 471065 WVVRATRtWVPKGLK intracellular localization 16899466 1 0 0 regulates CYP1A1 mitochondrial trafficking -Cebpb C/EBP-beta DNA-binding; Motility/polarity/chemotaxis; Transcription factor P21272 24253 3q42 rat S64-p 456166 HERAIDFsPYLEPLA transcription, induced; cell growth, altered 15314150; 17433708 8 0 1 -Ikbkb IKKB EC 2.7.11.10; KINASE; Kinase, protein; Protein kinase, Other; Protein kinase, Ser/Thr (non-receptor) O88351 16150 8|8 A2 mouse S697-p 17934903 QPSSACDsLPESDKK molecular association, regulation; phosphorylation PPP2R3C(INDUCES) 20925653 1 5 0 interaction with PPP2R3C (aka G4-1) downregulates IKK-beta activity; S181 phosphorylation increased in S679/682/689/692/697/701/705A mutant -ACSS1 ACSS1 Carbohydrate Metabolism - glycolysis and gluconeogenesis; Carbohydrate Metabolism - propanoate; Carbohydrate Metabolism - pyruvate; EC 6.2.1.1; Ligase; Mitochondrial Q9NUB1 84532 20p11.21 human K642-ac 464663 LPKTRSGkVMRRLLR AMP-binding_C enzymatic activity, inhibited 16788062 2 2 0 -STK26 MST4 EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, STE; Protein kinase, Ser/Thr (non-receptor) Q9P289 51765 Xq26.2 human T328-p 22781373 HPEWSFTtVRKKPDP molecular association, regulation carcinogenesis, induced; cell motility, induced MOB1A(INDUCES) 30072378 1 3 10 -CTNNB1 CTNNB1 Actin-binding; Cell adhesion; Motility/polarity/chemotaxis; Nuclear receptor co-regulator; Oncoprotein; Transcription factor P35222 1499 3p22.1 human K19-ub 486323 MAMEPDRkAAVSHWQ protein degradation carcinogenesis, inhibited; cell growth, inhibited; transcription, inhibited 16849322 1 5 0 K19 is primary site of ubquitination ; when both sites are mutated induces TCF transcription and transformation -Gata1 GATA1 DNA-binding; Transcription factor P17679 14460 X A1.1|X 3.59 cM mouse K316-ac 466359 ASGKGKKkRGSNLAG protein degradation; acetylation; ubiquitination; phosphorylation DNA(INDUCES) 16858405 2 0 0 Phosphorylation and acetylation cause the degradation of acetylated GATA-1; acetylation of GATA-1 causes ubiquitination; DNA binding is required for MAPK-dependent phosphorylation -WWC1 KIBRA Adaptor/scaffold Q8IX03 23286 5q34 human T929-p 3205626 STIIRSKtFSPGPQS cell motility, induced; cell growth, induced 24269383 1 11 4 -Clip1 Restin Cytoskeletal Q9JK25 65201 12q16 rat S1246-p 3189736 EDPNSYDsDDQEKQS molecular association, regulation dynactin 1(INDUCES) 20664522 3 17 0 -DROSHA DROSHA EC 3.1.26.3; Nucleolus; RNA processing; RNA-binding; Ribonuclease Q9NRR4 29102 5p13.3 human S300-p 14572630 RHRDNRRsPSLERSY molecular association, regulation; intracellular localization DGCR8(DISRUPTS) 20554852; 21674040; 25699712 3 15 0 -Adcy6 ADCY6 Adenylyl cyclase; EC 4.6.1.1; Lyase; Membrane protein, integral; Membrane protein, multi-pass; Nucleotide Metabolism - purine; Transporter; Transporter, aquaporin family AAA40678 25289 7q36 rat S568-p 455528 TFLILGAsQKRKEEK enzymatic activity, inhibited 11877398 1 0 0 -RHOA RHOA G protein; G protein, monomeric; G protein, monomeric, Rho; Motility/polarity/chemotaxis; Oncoprotein P61586 387 3p21.31 human Y34-p 473955 KDQFPEVyVPTVFEN Ras molecular association, regulation; activity, inhibited cytoskeletal reorganization; signaling pathway regulation PKN1(DISRUPTS); PKN2(DISRUPTS); Diaphanous-1(DISRUPTS); RTKN(DISRUPTS); ROCK2(DISRUPTS); DAAM1(DISRUPTS); ROCK1(DISRUPTS) 23027962 1 2 14 phosphorylation of this site inhibits binding of RhoA to cellular effectors; phosphorylation of this site inhibits F-actin formation -SREBF1 SREBP-1 DNA-binding; Membrane protein, integral; Membrane protein, multi-pass; Transcription factor P36956 6720 17p11.2 human S117-p 469986 YPSMPAFsPGPGIKE sumoylation transcription, induced; transcription, altered 10915800; 18403372; 20863500; 22384276 5 6 0 -MUC17 MUC17 Cell adhesion; Membrane protein, integral; Motility/polarity/chemotaxis Q685J3 140453 7q22.1 human S4492-p 1869193201 RPQVMTTsF______ intracellular localization 31387973 1 1 0 -DNM1L DRP1 Apoptosis; EC 3.6.5.5; Endoplasmic reticulum; Hydrolase; Microtubule-binding; Mitochondrial; Motor O00429 10059 12p11.21 human K568-sm 9859924 QDSRRETkNVASGGG activity, induced; intracellular localization 19638400 1 0 0 sumoylation is linked to its GTPase activity cycle, and influenced by DRP1 localization -SENP3 SENP3 DESUMOYLASE; EC 3.4.22.68; Nucleolus; Protease; Sumo-specific protease Q9H4L4 26168 17p13.1 human S141-p 36438201 RMLLYSKsTSLTFHW molecular association, regulation; intracellular localization NPM1(INDUCES) 25288641 1 1 0 ribosome biogenesis-28S rRNA maturation -PHF8 PHF8 DEMETHYLASE; Demethylase; EC 1.14.11.27; Nucleolus Q9UPP1 23133 Xp11.22 human S880-p 3216126 NSDDAPWsPKARVTP molecular association, regulation; methylation cell cycle regulation; transcription, induced DNA(INDUCES) 25548279 1 34 2 CDK2 phosphorylation of PHF8 enhances H3k9me2 demethylation -FANCD2 FANCD2 DNA repair, damage Q9BXW9 2177 3p25.3 human S1257-p 3925205 EPGTAADsQQIHEEK FancD2 activity, induced; molecular association, regulation; ubiquitination; intracellular localization signaling pathway regulation DNA(INDUCES) 37392383 1 7 0 regulates the FA pathway -Brsk2 BRSK2 EC 2.7.11.1; EC 2.7.11.26; KINASE; Kinase, protein; Protein kinase, CAMK; Protein kinase, Ser/Thr (non-receptor) Q69Z98 75770 7|7 F5 mouse T448-p 4734891 PLPTPKGtPVHTPKE protein stabilization; enzymatic activity, inhibited; phosphorylation 23790753 1 1 0 inhibits axon branching (activated in BRSK2 18A mutant) -PRKD2 PRKD2 EC 2.7.11.13; KINASE; Kinase, protein; Motility/polarity/chemotaxis; Protein kinase, CAMK; Protein kinase, Ser/Thr (non-receptor) Q9BZL6 25865 19q13.32 human S710-p 449865 GEKSFRRsVVGTPAY Pkinase molecular association, regulation; enzymatic activity, induced transcription, induced; signaling pathway regulation 14-3-3 eta(INDUCES); Exportin-1(DISRUPTS); 14-3-3 eta(DISRUPTS) 12058027; 17962809 5 28 63 -IKBKG IKKG Adaptor/scaffold; Protein kinase, regulatory subunit Q9Y6K9 8517 Xq28 human S85-p 458399 ELLHFQAsQREEKEF NEMO molecular association, regulation; ubiquitination; intracellular localization; phosphorylation transcription, induced; transcription, altered ATM(INDUCES) 16497931; 18583959; 21811235 5 0 0 -CA9 CA9 EC 4.2.1.1; Energy Metabolism - nitrogen; Lyase; Membrane protein, integral; Nucleolus Q16790 768 9p13.3 human T443-p 21691604 RRQHRRGtKGGVSYR molecular association, regulation; enzymatic activity, induced cell motility, induced MMP14(INDUCES) 22037869; 28692057 2 0 0 -CDC20 CDC20 Cell cycle regulation; Ubiquitin conjugating system Q12834 991 1p34.2 human S92-p 454660 AAQMEVAsFLLSKEN molecular association, regulation cell cycle regulation UBE2S(DISRUPTS) 26811472 2 4 0 phosphorylation-dependent regulation of Ube2S is coordinated with the microtubule-binding status of kinetochores -Src Src EC 2.7.10.2; KINASE; Kinase, protein; Oncoprotein; Protein kinase, TK; Protein kinase, tyrosine (non-receptor) Q9WUD9 83805 3q42 rat Y419-p 448234 RLIEDNEyTARQGAK PK_Tyr_Ser-Thr activity, induced; molecular association, regulation; phosphorylation; enzymatic activity, induced translation, altered; cell growth, induced; cytoskeletal reorganization; cell adhesion, altered; signaling pathway regulation ITGB3(INDUCES); ILK(INDUCES); caveolin-1(INDUCES) 14630916; 18252715; 18559349; 20676131; 21445358; 24611720; 25371038; 25672415; 34194565; 34830154; 36034878 447 103 3046 induces ERK signaling -TBK1 TBK1 EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, Other; Protein kinase, Ser/Thr (non-receptor) Q9UHD2 29110 12q14.2 human Y179-p 23151249 SLYGTEEyLHPDMYE Pkinase molecular association, regulation; phosphorylation signaling pathway regulation Other(INDUCES) 28049762; 36640307 3 1 4 induces binding to P protein of RABV thus inhibiting the interferon induction pathways; phosphorylation at the priming site induces autophosphorylation at S172. Production of type 1 IFN induced. Phosphorylation and activation of IRF3 induced -CD226 DNAM-1 Cell adhesion; Immunoglobulin superfamily; Membrane protein, integral Q15762 10666 18q22.2 human S329-p 450987 YVNYPTFsRRPKTRV activity, induced; molecular association, regulation ITGAL(INDUCES) 10591186; 15684041; 9712030 4 0 0 S329 phosphorylation is critical for DNAM-1 adhesion.; Wild type, but not S329 mutant, DNAM-1 associated with lipid rafts in the forming immunological synapse. -LRP5 LRP5 Membrane protein, integral; Receptor, misc. O75197 4041 11q13.2 human S1503-p 15411894 PILNPPPsPATDPSL enzymatic activity, induced 34205318 1 0 1 regulates HIF1A stability by inducing hydroxylation activity of PHD2 -DAP3 DAP3 Apoptosis; Mitochondrial; Nuclear receptor co-regulator P51398 7818 1q22 human S252-p 2226200 KELKRQSsLGMFHLL DAP3 apoptosis, induced 18227431 1 1 0 -FOXM1 FOXM1 DNA-binding; Transcription factor Q08050 2305 12p13.33 human K218-sm 31898504 HLEQRQVkVEEPSRP protein degradation; ubiquitination; intracellular localization cell cycle regulation; cell growth, inhibited; transcription, inhibited 24362530 2 0 0 -FOXO3 FOXO3A Autophagy; DNA-binding; Oncoprotein; Transcription factor O43524 2309 6q21 human K242-ac 460593 IINPDGGkSGKAPRR Forkhead activity, induced; protein stabilization; molecular association, regulation; ubiquitination; intracellular localization; phosphorylation apoptosis, induced; transcription, induced JNK1(INDUCES); SKP2(DISRUPTS) 21841822; 26376801; 27669435 5 0 0 -DCX Doublecortin Cytoskeletal; Motility/polarity/chemotaxis O43602 1641 Xq23 human S47-p 451112 TRTLQALsNEKKAKK molecular association, regulation; intracellular localization cytoskeletal reorganization TUBA1B(DISRUPTS); ACTA1(INDUCES) 15632197; 32050972 5 0 0 -HIF1A HIF1A Autophagy; DNA-binding; Transcription factor Q16665 3091 14q23.2 human S657-p 17331802 ETTSATSsPYRDTQS protein degradation 20889502 1 2 0 -ZWINT ZWINT Cell cycle regulation O95229 11130 10q21.1 human S250-p 20765004 PTRPQEQsTGDTMGR Zwint molecular association, regulation; intracellular localization; phosphorylation cell cycle regulation ZW10(INDUCES) 21775627 1 1 0 inhibits phosphorylation of dynein and induces its recruitment with ZW10 to kinetochores, -PARP1 PARP1 DNA repair, damage; EC 2.4.2.30; Nuclear envelope; Nuclear receptor co-regulator; Nucleolus; Transferase P09874 142 1q42.12 human T373-p 463805 AATPPPStASAPAAV enzymatic activity, induced transcription, induced 16627622; 23597856 2 1 0 -CDC42BPA MRCKA EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, AGC; Protein kinase, Ser/Thr (non-receptor) Q5VT25 8476 1q42.13 human T240-p 12612501 QSSVAVGtPDYISPE Pkinase enzymatic activity, induced cytoskeletal reorganization 11283256 1 0 0 -KDM5B JARID1B Cancer Testis Antigen (CTA); DEMETHYLASE; Demethylase; EC 1.14.11.-; Oxidoreductase; Transcription, coactivator/corepressor Q9UGL1 10765 1q32.1 human S1456-p 15404114 FKLERERsYELVRSA molecular association, regulation cell cycle regulation; carcinogenesis, induced; transcription, induced DNA(DISRUPTS) 31776402 1 6 3 induces mammosphere formation in cancer cells -RB1 Rb Nuclear receptor co-regulator; Oncoprotein; Transcription, coactivator/corepressor; Tumor suppressor P06400 5925 13q14.2 human K873-ac 459026 SNPPKPLkKLRFDIE Rb_C molecular association, regulation; intracellular localization; phosphorylation cell cycle regulation; cell differentiation, induced; transcription, induced E2F1(DISRUPTS); MDM2(INDUCES) 11433299; 15044952; 16374512 4 0 0 -TRPM8 TRPM8 Channel, cation; Membrane protein, integral; Membrane protein, multi-pass Q7Z2W7 79054 2q37.1 human S1040-p 34360655 CKEKNMEsSVCCFKN receptor desensitization, inhibited 32290846 1 0 1 -Vangl2 VANGL2 Adaptor/scaffold; Membrane protein, integral; Membrane protein, multi-pass Q91ZD4 93840 1 H3|1 79.54 cM mouse S84-p 18460401 GTSEHSIsHDDLTRI Strabismus activity, induced; protein stabilization 21316585 1 0 0 -Wasf1 WAVE1 Cytoskeletal; Motility/polarity/chemotaxis Q8R5H6 83767 10 B1|10 22.07 cM mouse S310-p 4764996 LIENRPQsPAAGRTP activity, inhibited 20403076 4 8 0 -H2AZ2 H2AFV Q71UI9 94239 7p13 human K4-ub 52485007 ____AGGkAGKDSGK Histone protein degradation 26676607 0 1 0 -CDKN1B p27Kip1 Cell cycle regulation; Inhibitor; Oncoprotein; Protein kinase, regulatory subunit P46527 1027 12p13.1 human T187-p 447875 NAGSVEQtPKKPGLR protein degradation; protein stabilization; molecular association, regulation; ubiquitination; protein conformation cell cycle regulation; carcinogenesis, induced; cell growth, induced CCND1(INDUCES); CDK2(DISRUPTS); CKS1(INDUCES); CUL1(INDUCES); CDK4(INDUCES); PIN1(INDUCES); SKP2(INDUCES); SKP1A(INDUCES) 10375532; 10781063; 10931950; 11726503; 12140288; 12700233; 16880511; 17053782; 17254966; 17409098; 18710949; 19204084; 19584057; 24336329; 27140628; 30976006; 33574916; 34407842 54 1 1 -Pam PAM EC 1.14.17.3; EC 4.3.2.5; Lyase; Membrane protein, integral; Oxidoreductase; Vesicle P14925 25508 9q37 rat S937-p 450813 FASRKGYsRKGFDRV protein stabilization; intracellular localization 10409666 1 0 0 Phosphorylation of PAM-1 at S937 directs newly synthesized and internalized protein away from lysosomes -SNCA SNCA Adaptor/scaffold P37840 6622 4q22.1 human T81-gl 1498941801 VTAVAQKtVEGAGSI Synuclein protein stabilization 30651314 0 1 0 inhibits the aggregation of alpha-synuclein but can also alter the structure of a-synuclein aggregates in site specific ways, inhibit a-Synuclein toxicity -Hcn4 HCN4 Channel, cation; Membrane protein, integral; Membrane protein, multi-pass O70507 330953 9|9 B mouse S1139-p 15103400 VTLPRKTsSGSLPPP activity, induced 20713547 1 0 0 required for PKA to shift the voltage dependence of HCN4 -IL4R IL4R Membrane protein, integral; Receptor, cytokine P24394 3566 16p12.1 human Y575-p 57775900 VSAPTSGyQEFVHAV molecular association, regulation GRB2(INDUCES) 27479084 1 0 0 Y575 and Arg576 (pY575R576) -CEBPB C/EBP-beta DNA-binding; Motility/polarity/chemotaxis; Transcription factor Q05826 chicken K39-me 1868113506 DCLAALNkLHPRAAG transcription, altered 18647749 1 0 0 -Irs1 IRS1 Adaptor/scaffold; Motility/polarity/chemotaxis P35569 16367 1 C5|1 42.0 cM mouse S632-p 447506 NGDYMPMsPKSVSAP protein degradation; molecular association, regulation neural plasticity; signaling pathway regulation PIK3C2A(DISRUPTS) 10092613; 23142081; 32075735; 34234788 41 26 1 -SCNN1A ENaC-alpha Channel, sodium; Membrane protein, integral; Membrane protein, multi-pass; Transporter, ion channel P37088 6337 12p13.31 human T663-p 456847 SAGASSStCPLGGP_ intracellular localization 17596527 1 1 0 -Camk2a CAMK2A EC 2.7.11.17; KINASE; Kinase, protein; Protein kinase, CAMK; Protein kinase, Ser/Thr (non-receptor) P11275 25400 18q12.1 rat T253-p 451571 DLINKMLtINPSKRI Pkinase intracellular localization cell cycle regulation; cell growth, inhibited; apoptosis, induced 16805815; 24407174 8 5 1 -CARD11 CARD11 Adaptor/scaffold Q9BXL7 84433 7p22.2 human S558-p 4737145 MQPPRSRsSIMSITA activity, induced 19706536 2 0 0 important for HPK1-mediated and TCR-mediated activation of NFkB-p65 -CCKBR CCKBR GPCR, family 1; Membrane protein, integral; Membrane protein, multi-pass; Receptor, GPCR P32239 887 11p15.4 human T439-p 6057804 SLSRLSYtTISTLGP molecular association, regulation ARRB1(INDUCES); RGS2(INDUCES) 19064631; 21156802 2 0 0 -LRRK1 LRRK1 EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, Ser/Thr (non-receptor); Protein kinase, TKL Q38SD2 79705 15q26.3 human T1075-p 1879806800 NQRNRCStFRVKRNQ phosphorylation; enzymatic activity, induced 36040231 1 1 0 induces Rab7 phosphorylation -ARHGAP22 ARHGAP22 GAP; GAP, Rac/Rho Q7Z5H3 58504 10q11.22-q11.23 human S16-p 22262003 ARRARSKsLVMGEQS molecular association, regulation cell motility, induced 14-3-3 beta(INDUCES) 21969604 1 8 0 -Grb10 GRB10 Adaptor/scaffold Q60760 14783 11 A1|11 7.15 cM mouse S501-p 4727990 TRMNILSsQSPLHPS molecular association, regulation; protein stabilization cell growth, inhibited; transcription, induced; signaling pathway regulation INSR(DISRUPTS); Raptor(INDUCES) 21659605; 24746805; 26000738 4 6 2 reduced soft agar colony formation ; thermogenic and lipolytic gene expression induced -Ripk1 RIPK1 EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, Ser/Thr (non-receptor); Protein kinase, TKL Q60855 19766 13 A3.3|13 14.01 cM mouse S321-p 468644 PVLQRMFsLQHDCVP molecular association, regulation; enzymatic activity, inhibited; enzymatic activity, induced apoptosis, inhibited RIPK3(DISRUPTS); CASP8(DISRUPTS); RIPK3(INDUCES); FADD(DISRUPTS) 28506461; 28842570; 28920954; 32366830; 34990405 11 27 34 -HRH1 H1R GPCR, family 1; Membrane protein, integral; Membrane protein, multi-pass; Receptor, GPCR P35367 3269 3p25.3 human T478-p 453403 CNENFKKtFKRILHI receptor desensitization, altered 15107581 1 0 0 -CENPJ CENPJ Cell cycle regulation; Microtubule-binding; Transcription, coactivator/corepressor Q9HC77 55835 13q12.12-q12.13 human S589-p 14918202 EQAADEIsFSSNSSF cell cycle regulation 20531387 1 0 0 required for centriole elongation -Nr5a2 NR5A2 DNA-binding; Nuclear receptor; Transcription factor P45448 26424 1 59.98 cM|1 E4 mouse K289-sm 6124701 HFPSRAIkSEYPDPY protein processing; intracellular localization transcription, inhibited 19125815; 28094767 3 1 0 -PRKAB1 AMPKB1 Autophagy; KINASE; Protein kinase, regulatory subunit Q9Y478 5564 12q24.23 human S108-p 448522 SKLPLTRsHNNFVAI AMPK1_CBM activity, induced; molecular association, regulation; phosphorylation 17728241; 22517326 11 64 2 activates AMPK1 and phosphorylation of T174; S108 mutation abolishes protective effect of salicylate and A-769662 binding, on T172 dephosphorylation. -RAD9A RAD9A Apoptosis; Cell cycle regulation; DNA replication; Deoxyribonuclease; EC 3.1.11.2 Q99638 5883 11q13.2 human S328-p 449812 VLPSISLsPGPQPPK molecular association, regulation; intracellular localization cell cycle regulation; apoptosis, induced; chromatin organization, altered TLK1(INDUCES) 12734188; 18940270; 20305300; 23028682; 26860083 8 11 8 accumulate Rad9 in the cytoplasm; translocated from the nucleus to the mitochondria during etoposide induced-apoptosis (Rad9 mediated apoptosis) -Agtr2 AT2 GPCR, family 1; Membrane protein, integral; Membrane protein, multi-pass; Receptor, GPCR P35351 24182 Xq34 rat S354-p 469106 MSCRKSSsLREMDTF activity, induced cell growth, altered 11040065 1 2 0 -TBC1D3 TBC1D3 GAP; GAP, Rab; Oncoprotein Q8IZP1 729873 17q12 human T165-p 64210901 FFRDRYGtKQRELLH RabGAP-TBC molecular association, regulation Calmodulin(NOT_REPORTED) 28422741 1 0 0 -NFKB1 NFkB-p105 DNA-binding; Transcription factor P19838 4790 4q24 human S903-p 455617 KTTSQAHsLPLSPAS protein stabilization 12871932 1 17 24 -DCX Doublecortin iso2 Cytoskeletal; Motility/polarity/chemotaxis O43602-2 1641 Xq23 human T331-p 469976 SKQSPIStPTSPGSL intracellular localization cell motility, altered; cytoskeletal reorganization 14765123 2 2 2 affects doublecortin localization to growth cones, neurite outgrowth, and neuronal motility -SP1 SP1 C2H2-type zinc finger protein; DNA-binding; Transcription factor P08047 6667 12q13.13 human T723-p 36897201 GVALSVGtLPLDSGA protein stabilization; molecular association, regulation; intracellular localization cell cycle regulation RNF4(DISRUPTS) DNA(DISRUPTS) 25398907 1 0 0 -NFKBIA IkB-alpha DNA-binding; Inhibitor P25963 4792 14q13.2 human Y305-p 448799 FTEDELPyDDCVFGG protein degradation; protein stabilization; intracellular localization; activity, inhibited apoptosis, induced; signaling pathway regulation; transcription, inhibited 12167702; 12909638; 30887112 3 0 5 NF-kB activation in BCR signaling -CEBPA C/EBP-alpha DNA-binding; Transcription factor P49715 1050 19q13.11 human S21-p 448308 PMSSHLQsPPHAPSS activity, induced; molecular association, regulation; protein conformation; activity, inhibited cell differentiation, inhibited; cell differentiation, altered; transcription, inhibited; transcription, altered DNA(DISRUPTS) 14701740; 16446383; 16807249; 20101026; 26515730 10 1 0 -Grin1 NMDAR1 Channel, calcium; Channel, ligand-gated; Membrane protein, integral; Membrane protein, multi-pass P35439 24408 3p13 rat S896-p 448255 SSFKRRRsSKDTSTG molecular association, regulation CAMK2A(DISRUPTS); Calmodulin(DISRUPTS) 36373991; 9252405 24 0 0 -SPTA1 SPTA1 Cytoskeletal; Motility/polarity/chemotaxis P02549 6708 1q23.1 human Y548-p 13421404 KLIGDDHyDSENIKA Spectrin cytoskeletal reorganization 20206558 1 1 0 -TCF3 E2A Cell development/differentiation; DNA-binding; Oncoprotein; Transcription factor P15923 6929 19p13.3 human S359-p 465682 SPSTPVGsPQGLAGT activity, inhibited transcription, inhibited 19801649 2 7 31 -OCLN occludin Cell adhesion; Membrane protein, integral; Membrane protein, multi-pass; Motility/polarity/chemotaxis Q16625 100506658 5q13.2 human T404-p 471472 HYETDYTtGGESCDE molecular association, regulation; intracellular localization occludin(DISRUPTS); ZO2(DISRUPTS) 19114660; 23758859 4 6 5 . Phosphorylation affects occludin solubility and regulates assembly/disassembly of TJ proteins -CYLD CYLD DEUBIQUITINASE; EC 3.4.19.12; Protease; Tumor suppressor; Ubiquitin conjugating system; Ubiquitin-specific protease Q9NQC7 1540 16q12.1 human S441-p 12173908 GHSPLSLsAQSVMEE CYLD_phos_site ubiquitination 15870263 1 0 0 induces ubiquitination of TRAF2 -EGFR EGFR EC 2.7.10.1; KINASE; Kinase, protein; Membrane protein, integral; Oncoprotein; Protein kinase, TK; Protein kinase, tyrosine (receptor) P00533 1956 7p11.2 human S1190-p 451819 PNGIFKGsTAENAEY receptor internalization, altered 7505275 1 1 4 -INCENP INCENP Cell cycle regulation; EC 2.7.11.1 Q9NQS7 3619 11q12.3 human S894-p 450468 RYHKRTSsAVWNSPP activity, induced; protein stabilization; molecular association, regulation; intracellular localization; enzymatic activity, induced cell cycle regulation INCENP(INDUCES) 12925766; 27332895; 27512725; 32028528 10 22 25 abscission during cytokinesis, colocalizes with and required for activation of Aurora B; induces AurB activity -RAF1 RAF1 EC 2.7.11.1; KINASE; Kinase, protein; Oncoprotein; Protein kinase, Ser/Thr (non-receptor); Protein kinase, TKL P04049 5894 3p25.2 human S287-p 9248144 AIRSHSEsASPSALS activity, induced cell cycle regulation 9933647 1 1 2 -CDKN2A p16-INK4A Cell cycle regulation; Nucleolus; Tumor suppressor P42771 1029 9p21.3 human S140-p 448831 AAGGTRGsNHARIDA Ank_2 protein stabilization; molecular association, regulation cell growth, inhibited; apoptosis, induced CDK4(INDUCES) 21270107; 28120917 4 0 0 -RHO Rhodopsin GPCR, family 1; Membrane protein, integral; Membrane protein, multi-pass; Receptor, GPCR P02699 509933 cow S343-p 448680 TVSKTETsQVAPA__ molecular association, regulation; protein conformation SAG(INDUCES) 15041682 5 7 0 Computational and in vitro data. S343 may be a weaker interaction. -Rps6ka3 RSK2 EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, AGC; Protein kinase, Ser/Thr (non-receptor) P18654 110651 X F4|X 73.27 cM mouse S227-p 448063 DHEKKAYsFCGTVEY Pkinase enzymatic activity, induced 10480933; 19956600 14 43 151 -Jun Jun Oncoprotein; Transcription factor P05627 16476 4 C5|4 43.34 cM mouse T91-p 450448 SNGHITTtPTPTQFL Jun molecular association, regulation NPM1(INDUCES); p14ARF(INDUCES) 18316603 8 2 0 -Kdr VEGFR2 EC 2.7.10.1; KINASE; Kinase, protein; Membrane protein, integral; Protein kinase, TK; Protein kinase, tyrosine (receptor) P35918 16542 5 C3.3|5 40.23 cM mouse Y1006-p 455661 TLEHLICySFQVAKG PK_Tyr_Ser-Thr molecular association, regulation cell growth, altered PLCG1(INDUCES) 12598525 1 0 0 -DOK1 DOK1 Adaptor/scaffold; Motility/polarity/chemotaxis Q99704 1796 2p13.1 human Y449-p 448879 KSHNSALySQVQKSG molecular association, regulation CD45(INDUCES); SH2D1A(INDUCES) 10852966; 19481264 3 40 1026 -Eif4ebp1 4E-BP1 Translation; Translation initiation Q60876 13685 8 A2|8 15.95 cM mouse T69-p 447528 RNSPVAKtPPKDLPA eIF_4EBP transcription, induced; translation, induced; signaling pathway regulation 18851840; 34704268 55 57 9 -TCAP Telethonin Motility/polarity/chemotaxis O15273 8557 17q12 human S157-p 448693 GALRRSLsRSMSQEA Telethonin protein degradation; ubiquitination cytoskeletal reorganization 24280220; 32937135 4 5 3 affects synchronous release and removal of Ca2 as a consequence of altered t-tubule organization -ACTA1 ACTA1 Cell development/differentiation; Contractile; Cytoskeletal; Motility/polarity/chemotaxis P68135 rabbit K217-ac 479596 IVRDIKEkLCYVALD Actin activity, inhibited 30962575 1 1 2 CAP/actin inhibitory potency -PIK3CG PIK3CG Autophagy; Carbohydrate Metabolism - inositol phosphate; EC 2.7.1.153; EC 2.7.11.1; KINASE; Kinase, lipid; Motility/polarity/chemotaxis; Protein kinase, Ser/Thr (non-receptor) P48736 5294 7q22.3 human T1024-p 20506703 YLALRHHtNLLIILF PI3_PI4_kinase enzymatic activity, inhibited 21474070 1 0 0 inhibits PIP3 production, enhances B-AR density, improves cardiac function in heart failure -NRK NRK EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, STE; Protein kinase, Ser/Thr (non-receptor) Q7Z2Y5 203447 Xq22.3 human K818-m2 58123000 SLLEQAQkPIDIRQR molecular association, regulation L3MBTL iso4(INDUCES) 23583077 0 1 0 -CTNNA1 CTNNA1 Actin-binding; Motility/polarity/chemotaxis P35221 1495 5q31.2 human S641-p 449139 TPEELDDsDFETEDF Vinculin molecular association, regulation; ubiquitination; intracellular localization; phosphorylation carcinogenesis, induced; carcinogenesis, inhibited; cell growth, inhibited; cell motility, induced; cell motility, inhibited; signaling pathway regulation; transcription, altered; cell growth, induced; cell motility, altered; cytoskeletal reorganization; transcription, inhibited CTNNB1(DISRUPTS); BTRC(DISRUPTS) 19941816; 31432583; 32256776; 34767814 5 98 78 Regulates Wnt and Hh signaling and inhibits cell invasion; inhibits IKB ubiquitination and degradation, inhibits NFkB signaling, regulates p65 phosphorylation and nuclear localization -ZC3HC1 NIPA Cell cycle regulation; Ubiquitin conjugating system Q86WB0 51530 7q32.2 human S354-p 449745 PIVSRTRsWDSSSPV molecular association, regulation cell cycle regulation; apoptosis, altered SKP1A(DISRUPTS) 12748172; 16009132; 17389604 4 41 32 -UHRF1 UHRF1 DNA-binding; EC 6.3.2.-; EC 6.3.2.19; Ligase; Transcription factor; UBIQUITIN LIGASE; Ubiquitin conjugating system; Ubiquitin ligase Q96T88 29128 19p13.3 human S639-p 471011 QQEGGFAsPRTGKGK protein degradation; molecular association, regulation; ubiquitination cell cycle regulation; cell growth, altered USP7(DISRUPTS) 22411829 3 20 1 -Hnrnpa1 hnRNP A1 Nuclear export; RNA splicing; RNA-binding; Spliceosome P04256 29578 7q36 rat S199-p 451555 SQRGRSGsGNFGGGR activity, inhibited 7727389 6 9 8 -MAP2K1 MEK1 EC 2.7.12.2; KINASE; Kinase, protein; Protein kinase, STE; Protein kinase, dual-specificity (non-receptor) P29678 100009316 rabbit S222-p 448513 LIDSMANsFVGTRSY Pkinase enzymatic activity, induced 7873542 117 20 203 in vitro -Plcg2 PLCG2 Carbohydrate Metabolism - inositol phosphate; EC 3.1.4.11; Motility/polarity/chemotaxis; Phospholipase P24135 29337 19q12 rat Y1217-p 447939 LNNQLFLyDTHQNLR enzymatic activity, induced 11507089 19 15 346 -TBK1 TBK1 EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, Other; Protein kinase, Ser/Thr (non-receptor) Q9UHD2 29110 12q14.2 human K30-ub 31033007 VFRGRHKkTGDLFAI Pkinase ubiquitination; intracellular localization; phosphorylation; enzymatic activity, induced transcription, induced; signaling pathway regulation 23453972; 27538435 3 1 0 ubquitination of one of these sites is required for S172 phosphorylation ; TBK1 trans-autophosphorylation phosphorylation at S172, enhances TBK1-induced phosphorylation of IRF3, regulation of downstream-signaling in innate immunity after RNA virus infection -GRN GRN Secreted; Secreted, signal peptide P28799 2896 17q21.31 human S81-p 41198100 IFTVSGTsSCCPFPE Granulin molecular association, regulation TNF-R2(DISRUPTS); TNF-R1(DISRUPTS); TNFRSF25(DISRUPTS) 26005049 1 0 0 -H4c2 H4 DNA-binding P62804 295277 rat K5-ac 458958 ___SGRGkGGKGLGK transcription, induced 19909801 72 22 516 -ZNF746 PARIS C2H2-type zinc finger protein; Transcription regulation Q6NUN9 155061 7q36.1 human S322-p 27533659 QATRFFPsPAQEGAW protein degradation; ubiquitination 28122242 1 2 0 protective effect of DA neuron toxicity -Gja1 GJA1 Channel, misc.; Membrane protein, integral; Membrane protein, multi-pass; Motility/polarity/chemotaxis P23242 14609 10 B4|10 28.64 cM mouse S373-p 459209 RASSRASsRPRPDDL activity, induced; protein degradation; molecular association, regulation; ubiquitination; intracellular localization; phosphorylation endocytosis, induced 14-3-3 theta(INDUCES) 24612377; 26869446; 27281705 19 7 0 internalization, induces phosphorylation at S368 and S255 -Htt Huntingtin Cytoskeletal P42859 15194 5 B2|5 17.92 cM mouse R95-m2 1881211200 NIVAQSLrNSPEFQK methylation; intracellular localization 33852844 1 1 0 Loss of arginine methylation at R118 reduced HTT recruitment to vesicles by 40%, impaired vesicle trafficking and induced neurotoxicity. -FERMT2 kindlin-2 Cytoskeletal; Motility/polarity/chemotaxis Q96AC1 10979 14q22.1 human S175-p 3208608 GPLITPGsGSIYSSP protein degradation; molecular association, regulation; ubiquitination cell cycle regulation; cell growth, induced; apoptosis, inhibited; cytoskeletal reorganization; cell adhesion, inhibited CUL9(INDUCES) 35469017 1 3 0 -MAP3K11 MLK3 EC 2.7.11.25; KINASE; Kinase, protein; Protein kinase, Ser/Thr (non-receptor); Protein kinase, TKL Q16584 4296 11q13.1 human S281-p 448262 WHKTTQMsAAGTYAW PK_Tyr_Ser-Thr molecular association, regulation; enzymatic activity, induced cell differentiation, induced GEFT(INDUCES) 11053428; 18851832; 21965325 8 0 0 -Marcksl1 MLP Cell cycle regulation P28667 17357 4 D2.2|4 63.26 cM mouse S120-p 454291 GGDSSASsPTEEEQE MARCKS protein conformation cytoskeletal reorganization; cell motility, inhibited 22751924 1 13 0 Increases actin stability and regulation of dendritic filopodium generation in neurons -DDAH2 DDAH2 Apoptosis; EC 3.5.3.18; Hydrolase O95865 23564 6p21.33 human S253-p 1872776108 QEALQKLsDVTLVPV intracellular localization; phosphorylation; enzymatic activity, induced signaling pathway regulation 33850055 1 1 0 regulates RLR signaling, regulates DRP1 anf IRF3 phosphorylation -PFKP PFKP Carbohydrate Metabolism - fructose and mannose; Carbohydrate Metabolism - galactose; Carbohydrate Metabolism - glycolysis and gluconeogenesis; Carbohydrate Metabolism - pentose phosphate pathway; EC 2.7.1.11; KINASE; Kinase, other Q01813 5214 10p15.2 human Y64-p 1426260400 VYFIYEGyQGMVDGG PFK molecular association, regulation; intracellular localization; phosphorylation; enzymatic activity, induced carcinogenesis, induced; cell motility, induced; cell growth, induced; transcription, induced; signaling pathway regulation PIK3R1(INDUCES) 29677490; 32195176; 36435833 3 1 0 -CD81 CD81 Membrane protein, integral; Membrane protein, multi-pass P60033 975 11p15.5 human K8-ub 4666602 MGVEGCTkCIKYLLF protein degradation endocytosis, induced 18713730; 31902824 2 0 0 cell surface downregulation of tetraspanins; clathrin-mediated endocytosis, poly-Ub chain binds to Lys8 at the intracellular N-terminal domain, degradation depends on the poly-ubiquitination of K8 -Kcnb1 Kv2.1 Channel, cation; Channel, ligand-gated; Channel, potassium; Membrane protein, integral; Membrane protein, multi-pass P15387 25736 3q42 rat K474-sm 25087004 KNGESIAkKDKVQDN Kv2channel activity, induced 21518833 2 1 0 -Cacna1d CACNA1D Channel, calcium; Membrane protein, integral; Membrane protein, multi-pass P27732 29716 16p16 rat S1743-p 6062700 VNSDRREsLQQTNTT CAC1F_C activity, induced 19074150 2 0 0 -DVL1 DVL1 Inhibitor O14640 1855 1p36.33 human K285-ac 1880010901 IYIGSIMkGGAVAAD intracellular localization transcription, inhibited 31700102 1 1 0 nuclear localization -Slc22a1 SLC22A1 Membrane protein, integral; Membrane protein, multi-pass; Transporter; Transporter, SLC family Q63089 24904 1q11 rat T296-p 455612 WLLSQKRtTRAVRIM Sugar_tr activity, induced 15829703 1 0 0 stimulates ASP+ uptake -SOD1 SOD1 Apoptosis; EC 1.15.1.1; Mitochondrial; Nuclear receptor co-regulator; Oxidoreductase P00441 6647 21q22.11 human K71-ac 466539 HFNPLSRkHGGPKDE Sod_Cu molecular association, regulation; enzymatic activity, inhibited carcinogenesis, inhibited CCS(DISRUPTS); SOD1(DISRUPTS) 26008972 1 1 4 -Cacna1c CACNA1C iso5 Channel, calcium; Membrane protein, integral; Membrane protein, multi-pass Q0PCR6 12288 6 F1|6 55.86 cM mouse S1927-p 455278 ASLGRRAsFHLECLK CAC1F_C activity, induced cell growth, induced 28119464; 28119465 31 3 0 long-term potentiation in response to prolonged theta-tetanus (PTT-LTP); increase channel activity -CHEK2 Chk2 EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, CAMK; Protein kinase, Ser/Thr (non-receptor); Tumor suppressor O96017 11200 22q12.1 human K235-ac 15293829 SGACGEVkLAFERKT Pkinase enzymatic activity, induced cell cycle regulation 30902968; 31209362 2 0 1 -CERT1 COL4A3BP EC 2.7.11.9; KINASE; Kinase, protein; Lipid-binding; Protein kinase, Ser/Thr (non-receptor); Protein kinase, atypical Q9Y5P4 10087 5q13.3 human S141-p 15409121 VSLVSGAsGYSATST molecular association, regulation; activity, inhibited 28652409 0 1 1 reduced PtdIns(4)P binding affinity as well as low ceramide transfer activity, E494R/N495K/P535R/E537K mutations, recovery of both PtdIns(4)P binding and ceramide transfer activity. -RASSF1 RASSF1 iso2 Tumor suppressor Q9NS23-2 11186 3p21.31 human S179-p 13258706 RPVSVPSsKKPPSLQ molecular association, regulation apoptosis, inhibited TRAIL-R1(DISRUPTS); 14-3-3 zeta(INDUCES); 14-3-3 epsilon(INDUCES); TNF-R1(DISRUPTS); MOAP1(DISRUPTS) 20069457 1 0 0 -RXRA RXRA DNA-binding; Motility/polarity/chemotaxis; Nuclear receptor P19793 6256 9q34.2 human S260-p 450891 NMGLNPSsPNDPVTN Hormone_recep molecular association, regulation; protein stabilization; intracellular localization; activity, inhibited carcinogenesis, induced; cell growth, induced; apoptosis, inhibited; signaling pathway regulation; transcription, inhibited; transcription, altered MED1(DISRUPTS); VDR(DISRUPTS); RARB(DISRUPTS); RXRA(DISRUPTS) DNA(DISRUPTS) 10377179; 11826406; 12048211; 16551633; 17900311; 18003614; 20432439; 27852823; 36282921 11 2 0 regulates JNK/RXRa/FGF21 signaling -VCP VCP Chaperone; DNA repair, damage; EC 3.6.4.6; Endoplasmic reticulum; Hydrolase P55072 7415 9p13.3 human Y805-p 449060 EDNDDDLyG______ molecular association, regulation; intracellular localization P130Cas(DISRUPTS) 29743287 6 10 251 enriched localization in focal adhesions -Sik1 SIK EC 2.7.11.1; KINASE; Kinase, protein; Motility/polarity/chemotaxis; Protein kinase, CAMK; Protein kinase, Ser/Thr (non-receptor); Tumor suppressor Q9R1U5 59329 20p12 rat T182-p 456034 KPGEPLStWCGSPPY Pkinase enzymatic activity, induced 32020874 8 0 0 -Map3k5 ASK1 EC 2.7.11.25; KINASE; Kinase, protein; Protein kinase, STE; Protein kinase, Ser/Thr (non-receptor) O35099 26408 10|10 A3 mouse T845-p 448394 GINPCTEtFTGTLQY Pkinase molecular association, regulation; enzymatic activity, induced apoptosis, induced; transcription, induced MKK3(INDUCES) 17210579; 18948261 20 2 1 AP-1 transcriptional activity -GRK2 GRK2 EC 2.7.11.15; KINASE; Kinase, protein; Protein kinase, AGC; Protein kinase, Ser/Thr (non-receptor) P21146 282682 cow S685-p 447726 VPLIQRGsANGL___ molecular association, regulation; intracellular localization ADRB2(INDUCES); DOR-1(INDUCES) 11278469; 28381559 3 11 1 at the plasma membrane -LMNB2 Lamin B2 Cytoskeletal; Motility/polarity/chemotaxis P14732 chicken S411-p 20657001 STSLVRSsRGKRRRI intracellular localization 8449977 1 0 0 nuclear uptake inhibited in vitro -PKP1 plakophilin 1 Cell adhesion; Motility/polarity/chemotaxis Q13835 5317 1q32.1 human S155-p 4712625 QKIKASRsEPDLYCD molecular association, regulation; intracellular localization cell adhesion, inhibited 14-3-3 gamma(INDUCES) 29678907 1 5 99 destabilizing desmosomal adhesion; increased the cytosolic fraction of PKP -TAB1 TAB1 Activator; Motility/polarity/chemotaxis Q15750 10454 22q13.1 human K319-ub 1881312004 MIDTEFAkQTSLDAV signaling pathway regulation 34017102 1 0 0 TRIM26 enhances TLRs-induced NF-kB and MAPK signaling. -FBXO43 FBX43 Unknown function Q4G163 286151 8q22.2 human S334-p 12581001 SISTPEDsGFNSLSL protein degradation; ubiquitination 15753281 1 0 0 -MAPK13 P38D EC 2.7.11.24; KINASE; Kinase, protein; Protein kinase, CMGC; Protein kinase, Ser/Thr (non-receptor) O15264 5603 6p21.31 human T180-p 4787496 RHADAEMtGYVVTRW Pkinase enzymatic activity, induced 10066767; 10201954 4 7 382 -Cdk2 CDK2 Cell cycle regulation; EC 2.7.11.22; KINASE; Kinase, protein; Protein kinase, CMGC; Protein kinase, Ser/Thr (non-receptor) P97377 12566 10|10 D3 mouse T14-p 447738 VEKIGEGtYGVVYKA Pkinase enzymatic activity, inhibited cell cycle regulation; cell differentiation, induced 20462953; 22331465 12 110 1499 regulates centrosome duplication -HDAC5 HDAC5 DEACETYLASE; Deacetylase; EC 3.5.1.98; Hydrolase Q9UQL6 10014 17q21.31 human S498-p 447996 RPLSRTQsSPLPQSP activity, induced; molecular association, regulation; enzymatic activity, inhibited; intracellular localization cell cycle regulation; apoptosis, induced; transcription, induced; transcription, altered; cell differentiation, altered; chromatin organization, altered; cell growth, induced; cell motility, altered HDAC3(DISRUPTS); 14-3-3 epsilon(INDUCES); TBL1X(DISRUPTS); TBL1XR1(DISRUPTS); GPS2(DISRUPTS); 14-3-3 beta(INDUCES); PRKD3(DISRUPTS); SMRT(DISRUPTS); N-CoR1(INDUCES); PRKD1(DISRUPTS); PRKD2(DISRUPTS) 11081517; 18184930; 18332134; 18951085; 21081666; 22243750; 23161540; 24120667; 24207022; 25012661; 28343149; 32485181 24 7 4 -E2F6 E2F6 DNA-binding; Transcription factor O75461 1876 2p25.1 human S52-p 29609300 EDNVQYVsMRKALKV molecular association, regulation transcription, induced DNA(DISRUPTS) 23954429 1 1 0 response to DNA replication stress -Abcc9 ABCC9 Channel, potassium; Membrane protein, integral; Membrane protein, multi-pass; Transporter; Transporter, ABC family P70170 20928 6 G2|6 74.35 cM mouse T633-p 483974 FESCKKHtGVQSKPI activity, induced 15087422 3 1 0 -MAP2K7 MKK7 EC 2.7.12.2; KINASE; Kinase, protein; Protein kinase, STE; Protein kinase, dual-specificity (non-receptor) O14733 5609 19p13.2 human S271-p 447697 ISGRLVDsKAKTRSA Pkinase enzymatic activity, induced transcription, altered 9312068 3 4 0 -ADRB2 ADRB2 GPCR, family 1; Membrane protein, integral; Membrane protein, multi-pass; Receptor, GPCR P07550 154 5q32 human S262-p 447909 GHGLRRSsKFCLKEH 7tm_1 receptor desensitization, inhibited 9461522 15 2 1 like wild type mutant acted in a dominant positive fashion -SREBF1 SREBP-1 DNA-binding; Membrane protein, integral; Membrane protein, multi-pass; Transcription factor P36956 6720 17p11.2 human S430-p 467201 DTLTPPPsDAGSPFQ protein degradation; molecular association, regulation; ubiquitination; phosphorylation transcription, induced FBXW7(INDUCES) 16825193; 19126544; 26759235 3 1 0 -MTOR mTOR Autophagy; EC 2.7.11.1; KINASE; Kinase, protein; Motility/polarity/chemotaxis; Protein kinase, Ser/Thr (non-receptor); Protein kinase, atypical P42345 2475 1p36.22 human S2481-p 447498 TVPESIHsFIGDGLV phosphorylation; enzymatic activity, induced cell cycle regulation; autophagy, inhibited; transcription, altered 10702316; 12807916; 20022946; 21900751; 34604061; 34711683 69 29 1 -Slc17a7 SLC17A7 Membrane protein, integral; Membrane protein, multi-pass; Transporter; Transporter, SLC family; Vesicle Q62634 116638 1q22 rat S519-p 4717544 GHDQLAGsDESEMED molecular association, regulation AP2A2(INDUCES) 25334008 1 1 0 -ITGB1BP1 ICAP1 Cell adhesion; Motility/polarity/chemotaxis O14713 9270 2p25.1 human T38-p 450887 GGLSRSStVASLDTD ICAP-1_inte_bdg activity, inhibited cell adhesion, altered 9813144 1 3 0 A T38D mutation is defective in cell spreading, while a T38A mutation stimulates cell spreading. -ATXN3 ataxin-3 DEUBIQUITINASE; DNA repair, damage; EC 3.4.19.12; Protease; Transcription regulation; Ubiquitin-specific protease P54252 4287 14q32.12 human K166-sm 31899108 GYSIFVVkGDLPDCE Josephin protein stabilization apoptosis, induced 23382880 1 0 0 -PTS PTS Cofactor and Vitamin Metabolism - folate biosynthesis; EC 4.2.3.12; Lyase; Mitochondrial Q03393 5805 11q23.1 human T58-p 1869465810 HNYKVVVtVHGEIDP PTPS molecular association, regulation; phosphorylation cell cycle regulation; carcinogenesis, induced; cell growth, induced; signaling pathway regulation LTBP1(INDUCES) 31628042 1 1 0 binds LTB1 subsequently stabilizing LTBP1-iNOS interaction, regulates LTBP1-TGF-? pathway, inhibits SMAD3 phosphorylation -ELL ELL Nuclear receptor co-regulator; Oncoprotein; Transcription initiation complex P55199 8178 19p13.11 human K5-ac 1875199402 ___MAALkEDRSYGL protein degradation 32152128 1 0 0 -PLCB1 PLCB1 Carbohydrate Metabolism - inositol phosphate; EC 3.1.4.11; Phospholipase Q9NQ66 23236 20p12.3 human S982-p 4787475 KKKSEPSsPDHGSST enzymatic activity, induced 11287604 1 1 0 S982 critical in IGF mediated activation of nuclear PI cycle -GRB10 GRB10 Adaptor/scaffold Q13322 2887 7p12.1 human Y67-p 448348 NASLESLySACSMQS molecular association, regulation INSR(DISRUPTS) 10871840 1 0 1 -PILRA PILRA Membrane protein, integral; Receptor, misc. Q9UKJ1 29992 7q22.1 human Y269-p 3141902 PKDDGIVyASLALSS molecular association, regulation SHP-1(INDUCES) 10660620 1 0 0 -DHCR24 Diminuto EC 1.3.1.72; Lipid Metabolism - steroid biosynthesis; Membrane protein, integral; Oxidoreductase Q15392 1718 1p32.3 human Y300-p 473188 LNSIGNYyKPWFFKH protein stabilization 24363437 1 0 1 -GABRB1 GABRB1 Channel, chloride; Channel, ligand-gated; Membrane protein, integral; Membrane protein, multi-pass; Transporter; Transporter, ion channel P18505 2560 4p12 human S409-p 451812 IQYRKPLsSREAYGR Neur_chan_memb activity, inhibited 28105535 4 0 0 orexin-mediated inhibition of the GABA-induced current -H4c2 H4 DNA-binding P62804 295277 rat K20-m1 1458623 GGAKRHRkVLRDNIQ CENP-T_C intracellular localization transcription, induced 33398850 30 15 7 increased lipid accumulation, activity of KMT5A and K20 methylation, in human and in rat placenta -Ptk2 FAK EC 2.7.10.2; KINASE; Kinase, protein; Protein kinase, TK; Protein kinase, tyrosine (non-receptor) P34152 14083 15 D3|15 33.94 cM mouse Y577-p 447890 YMEDSTYyKASKGKL PK_Tyr_Ser-Thr activity, induced; molecular association, regulation carcinogenesis, induced; cell growth, induced; cell adhesion, altered; transcription, altered; signaling pathway regulation P130Cas(INDUCES) 10672902; 36209205; 7529876; 9038154 88 40 1747 -FCRL6 FCRL6 Membrane protein, integral Q6DN72 343413 1q23.2 human Y371-p 12523300 GKDEGVVySVVHRTS molecular association, regulation SHP-2(INDUCES) 17213291 1 0 0 -EPHB1 EphB1 EC 2.7.10.1; KINASE; Kinase, protein; Membrane protein, integral; Protein kinase, TK; Protein kinase, tyrosine (receptor) P54762 2047 3q22.2 human Y928-p 3053617 SAIKMVQyRDSFLTA SAM_1 molecular association, regulation; phosphorylation cell motility, altered GRB7(INDUCES) 12223469 2 0 0 phosphorylation of Grb7 -PSEN1 PSEN1 Cell surface; EC 3.4.23.-; Membrane protein, integral; Membrane protein, multi-pass; Mitochondrial; Protease P49768 5663 14q24.2 human S365-p 3191053 RAAVQELsSSILAGE Presenilin protein conformation 28132667 2 15 1 PS1 pathogenic conformational shift -DDHD1 DDHD1 EC 3.1.1.-; Phospholipase Q8NEL9 80821 14q22.1 human S11-p 22351356 PGRGSPRsPEHNGRG intracellular localization; phosphorylation 34089703 1 7 12 regulates phosphorylation at other sites -Irf7 IRF7 DNA-binding; Transcription factor P70434 54123 7|7 F5 mouse S441-p 1276100 LCLSSTNsLYEDIEH transcription, induced DNA(INDUCES) 15743772 2 0 0 -Pdgfrb PDGFRB EC 2.7.10.1; KINASE; Kinase, protein; Membrane protein, integral; Oncoprotein; Protein kinase, TK; Protein kinase, tyrosine (receptor) Q05030 rat Y715-p 447524 CPPSTELySNALPVG PK_Tyr_Ser-Thr enzymatic activity, induced cell cycle regulation; cell growth, induced; signaling pathway regulation 23776396 5 1 2 downstream signaling pathway phosphorylation of STAT3, ERK1/2, Akt, and PLCG1 was determined in PDGF-stimulated VSMCs -Fmr1 FMR1 Nucleolus; RNA-binding; Translation P35922 14265 X A7.1|X 34.83 cM mouse R533-me 4046002 RRGDGRRrRGGGRGQ FXMRP1_C_core molecular association, regulation RNA(DISRUPTS) 20064924 2 0 0 methylation inhibits sc1 RNA binding; R533 and R538 determine association with polyribosomes; methylation doesnot inhibit AATYK mRNA association; different RNAs have distinct molecular requirements for binding to FMR1 -RIPK1 RIPK1 EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, Ser/Thr (non-receptor); Protein kinase, TKL Q13546 8737 6p25.2 human K140-ub 573768262 GVIHKDLkPENILVD PK_Tyr_Ser-Thr carcinogenesis, induced; cell growth, induced; apoptosis, inhibited; transcription, induced 37027301 1 3 0 TRIM21 affected the expression of the target genes of NF-kB R but not in PPDPF knockdown cells -Rb1 Rb Nuclear receptor co-regulator; Oncoprotein; Transcription, coactivator/corepressor; Tumor suppressor P33568 24708 15q11 rat S772-p 447978 STRPPTLsPIPHIPR Rb_C molecular association, regulation HDAC1(INDUCES) 19081374 98 17 128 -FASN FASN ACETYLTRANSFERASE; Acetyltransferase; EC 1.1.1.100; EC 1.3.1.39; EC 2.3.1.38; EC 2.3.1.39; EC 2.3.1.41; EC 2.3.1.85; EC 3.1.2.14; EC 4.2.1.59; Hydrolase; Lipid Metabolism - fatty acid biosynthesis; Lyase; Oxidoreductase P49327 2194 17q25.3 human T1032-p 27930801 NWVSFMDtMLQMSIL PS-DH transcription, inhibited 23585690 1 1 0 -UBA52-RPS27A-UBB-UBC ubiquitin Ubiquitin-like modifier P62988 2p16 human K6-ub 486300 __MQIFVkTLTGKTI ubiquitin protein degradation; molecular association, regulation; ubiquitination transcription, induced WRNIP1(INDUCES) DNA(INDUCES) 17550899; 32075857; 35659652 15 19 155 -ABCA1 ABCA1 Membrane protein, integral; Membrane protein, multi-pass; Transporter; Transporter, ABC family; Vesicle O95477 19 9q31.1 human Y1206-p 3718336 DIGHELTyVLPYEAA activity, inhibited 21402379 1 0 0 -Nlgn1 NLGN1 Membrane protein, integral Q99K10 192167 3|3 A3 mouse S839-p 1868546601 HPHPHSHsTTRV___ receptor recycling, inhibited; molecular association, regulation endocytosis, induced PSD-95(DISRUPTS) 31138690 1 1 0 regulates spinogenesis and excitatory synaptic transmission -MALT1 MALT1 Adaptor/scaffold; Apoptosis; EC 3.4.22.-; Ligase; Nuclear export; Protease; UBIQUITIN LIGASE; Ubiquitin conjugating system Q9UDY8 10892 18q21.32 human K648-ub 2134702 IDPKDANkGTPEETG MALT1_Ig protein degradation; molecular association, regulation IKKA(INDUCES) 17948050 2 3 0 activation of NF-kB pathway and IL-2 induction -STK3 MST2 Autophagy; EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, STE; Protein kinase, Ser/Thr (non-receptor) Q13188 6788 8q22.2 human Y81-p 25528501 MQQCDSPyVVKYYGS Pkinase molecular association, regulation; enzymatic activity, induced MST2(INDUCES); RAF1(DISRUPTS) 22590567 1 1 0 -Cish CISH O70512 83681 8q32 rat K187-ub 37044801 TPALPVSkPDAPGDP protein degradation 25448846 1 0 0 -SMAD3 SMAD3 DNA-binding; Nuclear receptor co-regulator; Transcription factor P84022 4088 15q22.33 human S208-p 451179 DAGSPNLsPNPMSPA protein degradation; intracellular localization; activity, inhibited; phosphorylation cell growth, induced; cell motility, inhibited; signaling pathway regulation; transcription, inhibited; transcription, altered; cell growth, altered 10197981; 15520018; 16156666; 20736297; 31722981; 33676893; 34504019 17 1 0 beta6 integrin expression; inhibits C-terminal phosphorylation and hence TGF-B signaling -RNMT RNMT EC 2.1.1.56; METHYLTRANSFERASE; Methyltransferase; RNA processing O43148 8731 18p11.21 human T77-p 454561 SSSCGKDtPSKKRKL enzymatic activity, induced cell growth, induced; translation, induced KPNA2(DISRUPTS) 26942677 1 27 11 -Ifngr2 IFNGR2 Membrane protein, integral Q63953 15980 mouse Y289-p 1341879204 IPEQIEEyLKDPDQF activity, induced; molecular association, regulation; intracellular localization EFHD2(INDUCES) 30318148 1 0 0 functional IFNGR2 formation, IFNG innate response -HIF1A HIF1A Autophagy; DNA-binding; Transcription factor Q16665 3091 14q23.2 human K532-ub 486268 SDMVNEFkLELVEKL protein degradation transcription, inhibited 10944113; 16862177 3 2 0 -HNRNPL hnRNP L RNA splicing; RNA-binding P14866 3191 19q13.2 human S544-p 15436636 GKSERSSsGLLEWES molecular association, regulation RNA(NOT_REPORTED) 22570490 1 4 0 -PCGF2 PCGF2 Transcription factor; UBIQUITIN LIGASE; Ubiquitin conjugating system; Ubiquitin ligase P35227 7703 17q12 human T334-p 34606690 TSRGRKMtVNGAPVP molecular association, regulation; ubiquitination carcinogenesis, induced; cell motility, induced; cell growth, induced; transcription, induced PHC1(DISRUPTS); CBX8(DISRUPTS) DNA(DISRUPTS) 33664452 1 1 1 inhibits H2A ubiquitination -MISP MISP Unknown function Q8IVT2 126353 19p13.3 human S376-p 3205356 GLHVGRAsTPDWVSE AKAP2_C molecular association, regulation ACTA1(DISRUPTS) 34023777 1 2 5 -TFE3 TFE3 DNA-binding; Oncoprotein; Transcription factor P19532 7030 Xp11.23 human S321-p 53350801 PAITVSNsCPAELPN activity, induced; intracellular localization autophagy, inhibited; transcription, inhibited; cell growth, altered 26813791; 29149494; 29945972 5 1 0 -APBB1 Fe65 Adaptor/scaffold; Apoptosis; Transcription regulation O00213 322 11p15.4 human K204-ac 1881304501 DGPREHSkSASLLFG transcription, induced 33938178 1 0 0 -Camk2a CAMK2A EC 2.7.11.17; KINASE; Kinase, protein; Protein kinase, CAMK; Protein kinase, Ser/Thr (non-receptor) P11798 12322 18 E1|18 34.41 cM mouse T286-p 447797 SCMHRQEtVDCLKKF activity, induced; molecular association, regulation; intracellular localization; protein conformation; phosphorylation; enzymatic activity, induced neural plasticity; signaling pathway regulation; cell growth, altered NMDAR1(INDUCES); Calmodulin(INDUCES); NMDAR2B(INDUCES) 12379661; 12408850; 18550767; 19004831; 19081380; 20381470; 21343908; 21627991; 22025701; 23467346; 23502535; 24038144; 24498331; 24812278; 28636948; 33064361; 33793303; 33853773; 35872016 155 34 72 -MFF MFF Membrane protein, integral; Mitochondrial Q9GZY8 56947 2q36.3 human S275-p 20651869 DNVRYGIsNIDTTIE Miff ubiquitination cell cycle regulation; cell growth, induced 34010649 1 2 0 inhibits ubiquitination and induces stability of Cyclin B1 -NEDD4L NEDD4L EC 6.3.2.-; EC 6.3.2.19; Ligase; UBIQUITIN LIGASE; Ubiquitin conjugating system; Ubiquitin ligase Q96PU5 23327 18q21.31 human T367-p 453439 AGRARSStVTGGEEP protein stabilization; phosphorylation ENaC-alpha(INDUCES) 15328345; 24657276 5 3 15 -STAT2 STAT2 DNA-binding; Transcription factor P52630 6773 12q13.3 human S734-p 60199700 LVPEPELsLDLEPLL transcription, induced 27802159 1 1 0 subset of IFN-stimulated antiviral genes -Nfatc2 NFAT1 DNA-binding; Transcription factor Q60591 18019 2 H3|2 88.91 cM mouse S170-p 449624 YREPLCLsPASSGSS activity, induced transcription, induced; transcription, inhibited 11030334; 15743762 2 1 0 -HBP1 HBP1 DNA-binding; Transcription factor O60381 26959 7q22.3 human K171-ac 25171018 AFPHHHWkEETPVRH transcription, inhibited 23249948 2 0 0 acetylation of the five sites induces transcriptional repression of the DNMT1 gene, regulates cellular senescence -Brsk2 BRSK2 EC 2.7.11.1; EC 2.7.11.26; KINASE; Kinase, protein; Protein kinase, CAMK; Protein kinase, Ser/Thr (non-receptor) D3ZML2 293631 1q41 rat T175-p 456031 VGDSLLEtSCGSPHY Pkinase intracellular localization; enzymatic activity, induced 29698519 5 1 1 activation of Sad kinases in the axon during development; Sad kinases are required for the survival of cortical neurons -CSNK1A1 CK1A EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, CK1; Protein kinase, Ser/Thr (non-receptor) P48729 1452 5q32 human S218-p 11333100 LMYFNRTsLPWQGLK Pkinase molecular association, regulation 14-3-3 eta(INDUCES) 19860830 1 0 0 -NTRK1 TrkA EC 2.7.10.1; KINASE; Kinase, protein; Membrane protein, integral; Oncoprotein; Protein kinase, TK; Protein kinase, tyrosine (receptor) P04629 4914 1q23.1 human Y701-p 2035400 MPPESILyRKFTTES PK_Tyr_Ser-Thr protein stabilization; molecular association, regulation; receptor internalization, altered; protein processing; enzymatic activity, inhibited; phosphorylation cell differentiation, altered; cell growth, altered LAMP1(INDUCES); CLTC(INDUCES) 18173729 1 0 1 Y701D mutation inhibits receptor autophosphorylation in vivo, but not in vitro -ALOX5 5-LO EC 1.13.11.34; Lipid Metabolism - arachidonic acid; Lipid Metabolism - linoleic acid; Nuclear envelope; Oxidoreductase P09917 240 10q11.21 human S664-p 461913 QLPYYYLsPDRIPNS enzymatic activity, induced 12670876; 36682398 5 1 0 -KDR VEGFR2 EC 2.7.10.1; KINASE; Kinase, protein; Membrane protein, integral; Protein kinase, TK; Protein kinase, tyrosine (receptor) P35968 3791 4q12 human Y951-p 447903 RFRQGKDyVGAIPVD PK_Tyr_Ser-Thr activity, induced; molecular association, regulation; receptor internalization, altered; phosphorylation; enzymatic activity, induced cell growth, induced; cell motility, altered PLCG1(INDUCES) 10102632; 11435426; 16891660; 28817576 20 0 3 -TCF3 E2A iso2 Cell development/differentiation; DNA-binding; Oncoprotein; Transcription factor P15923-2 6929 19p13.3 human S352-p 465681 SSNNFSSsPSTPVGS molecular association, regulation transcription, induced NEUROD1(INDUCES) 12810726 2 1 4 -SP1 SP1 C2H2-type zinc finger protein; DNA-binding; Transcription factor P08047 6667 12q13.13 human S698-p 5262507 CPKRFMRsDHLSKHI zf-C2H2 protein stabilization; molecular association, regulation carcinogenesis, induced; cell motility, induced; transcription, induced; signaling pathway regulation DNA(INDUCES) 22718198 1 1 0 AKT/SP1/CCR7 pathway -EDNRA EDNRA GPCR, family 1; Membrane protein, integral; Membrane protein, multi-pass; Motility/polarity/chemotaxis; Receptor, GPCR P25101 1909 4q31.22-q31.23 human S397-p 2911713 QSKSLMTsVPMNGTS receptor desensitization, induced 24064210 1 1 0 Lack of S397, T403 and S404 influences desensitization to a greater extent compared than S391, S393, and T396 -FOXO1 FOXO1A DNA-binding; Nuclear receptor co-regulator; Oncoprotein; Transcription factor Q12778 2308 13q14.11 human S235-p 4258802 NEGTGKSsWWMLNPE Forkhead molecular association, regulation DNA(DISRUPTS) 18786403 3 1 0 -Lpin1 LPIN1 EC 3.1.3.4; Phosphatase, lipid Q91ZP3 14245 12 A1.1|12 7.9 cM mouse S285-p 471346 SRPSTPKsDSELVSK molecular association, regulation; intracellular localization; phosphorylation 14-3-3 beta(INDUCES) 30617183 2 10 2 stimulates phosphorylation of S287 -ZRANB1 ZRANB1 DEUBIQUITINASE; EC 3.4.19.12; Ligase; Protease; Ubiquitin conjugating system; Ubiquitin-specific protease Q9UGI0 54764 10q26.13 human T117-p 1105513502 QRRTRSPtESPQSSG enzymatic activity, induced 29748601 1 1 0 phosphorylation induced by AKT induces K63 deubiquitinating activity toward Twist1 -Gabbr1 GABBR1 GPCR, family 3; Membrane protein, integral; Membrane protein, multi-pass; Receptor, GPCR Q9Z0U4 81657 20p12 rat S898-p 15167000 ITRGEWQsETQDTMK receptor recycling, inhibited; protein degradation; molecular association, regulation; ubiquitination MIB2(INDUCES) 29881949 3 0 1 -Ryr1 RYR1 Channel, calcium; Membrane protein, integral; Membrane protein, multi-pass; Transporter; Transporter, ion channel E9PZQ0 20190 7 B1|7 16.94 cM mouse T4338-p 34348504 ALLWALVtRAGGAGA protein degradation; ubiquitination 35469018 1 2 1 -Mip AQP0 Channel, misc.; Membrane protein, integral; Membrane protein, multi-pass; Transporter, aquaporin family P09011 25480 7q11 rat S241-p 451790 ILKGARPsDSNGQPE molecular association, regulation 22194645 2 1 0 No differences in the interaction with filensin between the AQP0 COOH-terminal peptide and its pseudophosphorylated proteins -POLI POLI DNA repair, damage; EC 2.7.7.7; Transferase Q9UNA4 11201 18q21.2 human K555-ub 12253556 SREKFQGkGSVSCPL protein degradation 26370087 1 6 1 -MLF2 MLF2 Cell adhesion Q15773 8079 12p13.31 human S28-p 13261776 AIHRQHMsRMLSGGF Mlf1IP activity, induced carcinogenesis, induced; cell growth, induced 31831854 1 2 0 -TELO2 TELO2 Adaptor/scaffold Q9Y4R8 9894 16p13.3 human S487-p 15668105 AQLAGSDsDLDSDDE molecular association, regulation; enzymatic activity, induced DNAPK(INDUCES); ATM(INDUCES); PIH1D1(INDUCES) 20864032; 24657168 4 2 0 increase stablization of DNA-PKs, ATM and PIKKs; this interaction (as a part of R2TP/prefoldin-like complex) is important for mTor and Smg1 stability -PDE3B PDE3B EC 3.1.4.17; Membrane protein, integral; Membrane protein, multi-pass; Nucleotide Metabolism - purine; Phosphodiesterase Q13370 5140 11p15.2 human S318-p 449873 CKIFRRPsLPCISRE molecular association, regulation; enzymatic activity, induced 14-3-3 beta(INDUCES); 14-3-3 eta(INDUCES) 17255105 7 18 27 -MAVS MAVS Adaptor/scaffold; Membrane protein, integral Q7Z434 57506 20p13 human K7-ub 27197145 _MPFAEDkTYKYICR CARD_2 protein degradation 26246171 2 2 0 inhibits RLR-mediated antiviral signaling -EEF1A1 EEF1A1 Nucleolus; Translation; Translation elongation P68104 1915 6q13 human K165-m1 8113920 TEPPYSQkRYEEIVK GTP_EFTU molecular association, regulation translation, altered L3MBTL iso4(INDUCES); EEF1D(DISRUPTS); eEF1B(DISRUPTS); EEF1G(DISRUPTS) 23583077; 28108655 2 8 46 -Limk1 LIMK1 EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, Ser/Thr (non-receptor); Protein kinase, TKL P53668 16885 5 74.73 cM|5 G2 mouse T508-p 447808 PDRKKRYtVVGNPYW PK_Tyr_Ser-Thr neural plasticity; cytoskeletal reorganization 35487245; 36044862 30 2 1 -CENPJ CENPJ Cell cycle regulation; Microtubule-binding; Transcription, coactivator/corepressor Q9HC77 55835 13q12.12-q12.13 human S467-p 31855585 LKCSNRKsLSPSGLK intracellular localization cell cycle regulation 26997271 1 6 0 mitotic spindle poles, CPAP-S467A has a high af?nity for MTs -Lmo7 LMO7 iso3 Adaptor/scaffold Q6JBI6 361084 15q21 rat S1295-p 50307600 LAGSVKTsPGSPSPR intracellular localization endocytosis, induced ATP1A1(INDUCES) 26370512 1 0 0 Na,K-ATPase endocytosis during hypercapnia -IL17RB IL17RB Membrane protein, integral Q9NRM6 55540 3p21.1 human Y447-p 5756439 LHKYVVVyFREIDTK SEFIR molecular association, regulation; ubiquitination; phosphorylation cell differentiation, inhibited; carcinogenesis, induced; cell growth, induced; transcription, induced; signaling pathway regulation TRIM56(INDUCES) 33658352 2 0 0 induces ERK phosphorylation and IL-17B/IL-17RB signal transduction -VPS4A VPS4A EC 3.6.4.6; Vesicle Q9UN37 27183 16q22.1 human K121-ub 573790636 MGAVVMEkPNIRWND molecular association, regulation; ubiquitination; enzymatic activity, induced CHMP1B(INDUCES) 35044214 1 2 0 interaction after HCV infection, enhances VPS4A ATPase activity, release of HCV particles -TGS1 PIMT EC 2.1.1.-; METHYLTRANSFERASE; Methyltransferase; Nuclear receptor co-regulator; RNA processing Q96RS0 96764 8q12.1 human S298-p 3636737 DLVSFPSsPIMVDND transcription, induced 24358311 2 3 2 PEPCK promoter binding and transcription, augment hepatic glucose output, and enhance gluconeogenic genes -Calm1 Calmodulin Calcium-binding; Protein phosphatase, regulatory subunit P0DP29 24242 6q32 rat T80-p 448704 MARKMKDtDSEEEIR molecular association, regulation; activity, inhibited KCNQ4(INDUCES) 15363395; 24627475; 8206911 11 6 0 accelrates SK channel deactivation; T80 site is key to binding. CAM phosphorylation regulates channel trafficking and stabilizes activity-thereby regulating neuronal excitability.; Calmodulin phosphorylated by CKII in vitro showed reduced activation of erythrocyte plasma membrane Ca2+ pump. -TRIOBP Tara iso5 Actin-binding; Cytoskeletal; Motility/polarity/chemotaxis Q9H2D6-5 11078 22q13.1 human T457-p 27171500 QAEEREHtLRRCQQE molecular association, regulation; intracellular localization cell cycle regulation TRF1(INDUCES) 22820163; 24692559 2 1 0 required for accurate chromosome segregation; localized to centrosome during mitosis -STAT6 STAT6 DNA-binding; Transcription factor P42226 6778 12q13.3 human K284-ac 1883988601 KQPPQVLkTQTKFQA molecular association, regulation; intracellular localization transcription, inhibited MLLT3(INDUCES) 37308587 1 1 0 attenuates the expression of genes involved in both purine metabolism and metastasis -Rela NFkB-p65 DNA-binding; Nuclear receptor co-regulator; Transcription factor Q04207 19697 19 A|19 4.34 cM mouse S276-p 447798 SMQLRRPsDRELSEP RHD_dimer activity, induced; protein degradation; acetylation; molecular association, regulation; protein processing cell differentiation, altered; apoptosis, altered; chromatin organization, altered; transcription, induced; transcription, inhibited; transcription, altered HDAC3(DISRUPTS); CDK9(INDUCES); p300(INDUCES); RELB(INDUCES); CBP(INDUCES); BRD4(INDUCES) 12874295; 16135789; 16192349; 17590163; 18408078; 19965984; 21900162; 30716535; 34474272; 35530146; 36223242; 9150141 90 0 0 -POU5F1 Oct4 DNA-binding; Transcription factor Q01860 5460 6p21.33 human S111-p 25236703 ESNSDGAsPEPCTVT protein degradation; ubiquitination; intracellular localization; activity, inhibited transcription, induced; transcription, altered 23024368; 33565603 4 2 0 -RAF1 RAF1 EC 2.7.11.1; KINASE; Kinase, protein; Oncoprotein; Protein kinase, Ser/Thr (non-receptor); Protein kinase, TKL P04049 5894 3p25.2 human S291-p 4274389 HSESASPsALSSSPN activity, induced cell cycle regulation 9933647 1 1 15 -Syn1 SYN1 Vesicle P09951 24949 Xq11 rat S576-gl 5505104 GPAPPKVsGASPGGQ phosphorylation 10386995 1 1 0 in the presnce of two GlcNAcs CaM Kinase II activity had a 66% increase in KM with no effect on Vmax or Kcat -Creb1 CREB iso1 DNA-binding; Transcription factor Q01147-1 12912 mouse K285-sm 12063903 PAEEAARkREVRLMK bZIP_1 cell differentiation, inhibited; transcription, induced 31433978 2 0 0 -TP53 p53 Activator; DNA-binding; Motility/polarity/chemotaxis; Nuclear receptor co-regulator; Transcription factor; Tumor suppressor P04637 7157 17p13.1 human K372-me 2344805 HSSHLKSkKGQSTSR activity, induced; molecular association, regulation; protein stabilization; acetylation cell cycle regulation; transcription, induced Tip60(INDUCES) 17646389; 18280244 5 0 0 K372-me stimulate p53 acetylation, thus enhancing the stability and activity of p53, which ultimately results in transcriptional upregulation (p21- cell cycle arrest) -Mc2r MC2R GPCR, family 1; Membrane protein, integral; Membrane protein, multi-pass; Receptor, GPCR Q64326 17200 18 E2|18 41.89 cM mouse S280-p 456325 PFIYAFRsPELRDAF receptor desensitization, altered; activity, inhibited 12456795 1 0 0 -RNH1 RNH1 Inhibitor P13489 6050 11p15.5 human K226-ub 12405189 LCGIVASkASLRELA LRR_6 protein degradation cell growth, induced; signaling pathway regulation 32521278 1 6 3 -RPL12 RPL12 Ribosomal; Translation P30050 6136 9q33.3 human S38-p 468652 KIGPLGLsPKKVGDD Ribosomal_L11_N cell cycle regulation; translation, induced 30220558 2 66 5 regulates translation of mitotic-related mRNAs -CD84 CD84 Cell surface; Immunoglobulin superfamily; Membrane protein, integral; Motility/polarity/chemotaxis Q9UIB8 8832 1q23.3 human Y316-p 454841 EEPVNTVySEVQFAD molecular association, regulation cell growth, altered SH2D1B(NOT_REPORTED); SH2D1B(INDUCES); Arg(NOT_REPORTED) 12928397; 23322602 1 8 203 -CBL CBL Adaptor/scaffold; EC 6.3.2.-; EC 6.3.2.19; Ligase; Motility/polarity/chemotaxis; Oncoprotein; UBIQUITIN LIGASE; Ubiquitin conjugating system; Ubiquitin ligase P22681 867 11q23.3 human S623-p 10288600 NRHSLPFsLPSQMEP molecular association, regulation 14-3-3 eta(INDUCES) 11024037 1 1 2 -Nr2c1 NR2C1 DNA-binding; Nuclear receptor Q505F1 22025 10 C2|10 48.81 cM mouse T210-p 4206803 SPLAATPtFVTDSET sumoylation; molecular association, regulation HDAC3(INDUCES); PML(INDUCES) 18682553; 19204783 2 1 0 triggers NR2C1 localization to promyelocytic leukemia (PML) nuclear bodies -Spi1 PU.1 DNA-binding; Oncoprotein; Transcription factor P17433 20375 2 E1|2 50.44 cM mouse S142-p 451055 EEEGERQsPPLEVSD activity, induced transcription, induced 12612065 2 2 0 -Ctnnd2 CTNND2 Actin-binding; Motility/polarity/chemotaxis O35927 18163 15|15 B2 mouse Y1112-p 473157 LKERKTDyESAGNNA protein stabilization; molecular association, regulation GSK3B(DISRUPTS) 24412473 1 0 6 increased ability of CTNND2 to enhance the nuclear distribution of B-catenin via E-cadherin -SRC Src EC 2.7.10.2; KINASE; Kinase, protein; Oncoprotein; Protein kinase, TK; Protein kinase, tyrosine (non-receptor) P12931 6714 20q11.23 human S75-p 450326 NSSDTVTsPQRAGPL protein degradation; ubiquitination; enzymatic activity, inhibited; enzymatic activity, induced; phosphorylation cytoskeletal reorganization; cell growth, altered 21442427; 9271228 9 24 3 -GALNT2 GALNT2 EC 2.4.1.41; Glycan Metabolism - O-glycan biosynthesis; Membrane protein, integral; Transferase Q10471 2590 1q42.13 human S373-ac 25336509 PYTFPGGsGTVFARN enzymatic activity, inhibited; O-GalNAc glycosylation 21651894 0 1 0 inhibits glycosylation of mucin -TRPS1 TRPS1 C2H2-type zinc finger protein; Transcription factor Q9UHF7 7227 8q23.3 human K1192-sm 3278912 TKAPPNVkNEGPLNV transcription, inhibited 17391059 2 0 0 -RELA NFkB-p65 DNA-binding; Nuclear receptor co-regulator; Transcription factor Q04206 5970 11q13.1 human K123-ac 458971 LGIQCVKkRDLEQAI RHD_DNA_bind molecular association, regulation; intracellular localization transcription, inhibited DNA(DISRUPTS) 12419806; 23087373 4 0 0 inhibits inflammatory gene expression -Cyth3 cytohesin 3 GEF; GEF, ARF; Lipid-binding; Nuclear receptor co-regulator; Receptor, misc. O08967 19159 5 G2|5 82.36 cM mouse T280-p 25585002 KLGGRVKtWKRRWFI PH molecular association, regulation; receptor recycling, induced; intracellular localization GLUT4(INDUCES) 22609160 1 0 0 Glut4 vesicle formation -Tfeb TFEB DNA-binding; Transcription factor Q9R210 21425 17 C|17 23.99 cM mouse S461-p 4785127 SPEASKAsSRRSSFS DUF3371 protein stabilization; intracellular localization autophagy, induced; transcription, induced 23599343; 35686465 2 0 0 -Tagln TAGLN Actin-binding; Motility/polarity/chemotaxis; Nuclear receptor co-regulator P31232 25123 8q22 rat T139-p 18016558 ALGSLAVtKNDGHYR CH protein degradation; molecular association, regulation IkB-alpha(DISRUPTS) 25937534 1 1 0 -AURKA AurA EC 2.7.11.1; KINASE; Kinase, protein; Oncoprotein; Protein kinase, Other; Protein kinase, Ser/Thr (non-receptor) O14965 6790 20q13.2 human S89-p 25157200 TSVPHPVsRPLNNTQ enzymatic activity, induced cell cycle regulation; cytoskeletal reorganization 22451695 1 0 0 -BLVRA BVR Cofactor and Vitamin Metabolism - porphyrin and chlorophyll; EC 1.3.1.24; KINASE; Kinase, protein; Oxidoreductase; Protein kinase, Ser/Thr (non-receptor) P53004 644 7p13 human S237-p 4774274 SFHFKSGsLENVPNV Biliv-reduc_cat enzymatic activity, induced 22584576 1 7 0 -AGO2 AGO2 EC 3.1.26.n2; RNA processing; RNA-binding Q9UKV8 27161 8q24.3 human Y749-p 13830224 HPTEFDFyLCSHAGI Piwi carcinogenesis, induced 31981897 1 1 0 -DDR1 DDR1 EC 2.7.10.1; KINASE; Kinase, protein; Membrane protein, integral; Protein kinase, TK; Protein kinase, tyrosine (receptor) Q08345 780 6p21.33 human Y569-p 1869973810 PQNSVPHyAEADIVT enzymatic activity, induced 32839343 1 1 0 -INSR INSR EC 2.7.10.1; KINASE; Kinase, protein; Membrane protein, integral; Protein kinase, TK; Protein kinase, tyrosine (receptor) P06213 3643 19p13.2 human T1375-p 450327 KKNGRILtLPRSNPS enzymatic activity, inhibited; phosphorylation 7615833; 8454604 6 1 8 -CEBPE C/EBP-epsilon DNA-binding; Motility/polarity/chemotaxis; Transcription factor Q15744 1053 14q11.2 human T74-p 455780 RGLKGPGtPAFPHYL molecular association, regulation cell differentiation, altered; transcription, induced NFkB-p65(INDUCES) DNA(INDUCES) 15677566; 17255362 2 0 6 -CALM1 Calmodulin Calcium-binding; Protein phosphatase, regulatory subunit P0DP23 801 14q32.11 human Y100-p 448707 FDKDGNGyISAAELR EF-hand_7 molecular association, regulation; intracellular localization TRPC6(DISRUPTS); PIK3R1(INDUCES) 26858457 5 75 2115 -Prkcd PKCD EC 2.7.11.13; KINASE; Kinase, protein; Nuclear receptor co-regulator; Protein kinase, AGC; Protein kinase, Ser/Thr (non-receptor); Protein kinase, tyrosine (non-receptor); Tumor suppressor P09215 170538 16p16 rat S643-p 448591 LNEKPQLsFSDKNLI Pkinase_C enzymatic activity, induced 16361709 29 51 79 -FOXO1 FOXO1A DNA-binding; Nuclear receptor co-regulator; Oncoprotein; Transcription factor Q12778 2308 13q14.11 human T317-gl 10902808 WSTFRPRtSSNASTI activity, induced transcription, induced 18420577 1 1 0 -ADRA1D ADRA1D GPCR, family 1; Membrane protein, integral; Membrane protein, multi-pass; Receptor, GPCR P25100 146 20p13 human S323-p 1424270002 DGAHGMRsAKGHTFR 7tm_1 receptor internalization, altered signaling pathway regulation 29551601 1 1 0 regulates ERK signaling pathway, induces calcium signaling de-sensitization -RAD17 RAD17 Cell cycle regulation O75943 5884 5q13.2 human S362-p 23136919 KKGMSLKsDAVLSKS molecular association, regulation RAD1(INDUCES) 29902452 1 0 1 -BUB1 BUB1 Cell cycle regulation; EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, Other; Protein kinase, Ser/Thr (non-receptor) O43683 699 2q13 human T609-p 465611 SAAQLAStPFHKLPV molecular association, regulation; intracellular localization; phosphorylation cell cycle regulation; signaling pathway regulation PLK1(INDUCES) 16760428; 33125045; 34551298 3 1 0 induces KNL1-MELT signaling; induces PLK1 recruitment -H3C1 H3 DNA-binding P68431 8350 6p22.2 human T80-p 4710889 EIAQDFKtDLRFQSS Histone cell cycle regulation; cell growth, induced 23227340 1 16 23 indicator of mitosis and tumor cell proliferation -Sod2 SOD2 EC 1.15.1.1; Mitochondrial; Oxidoreductase P09671 20656 17 A1|17 8.75 cM mouse K154-ac 27585065 WGWLGFNkEQGRLQI Sod_Fe_C protein conformation; enzymatic activity, altered 28433661 0 2 0 -CTNNB1 CTNNB1 Actin-binding; Cell adhesion; Motility/polarity/chemotaxis; Nuclear receptor co-regulator; Oncoprotein; Transcription factor P35222 1499 3p22.1 human Y333-p 471406 NIMRTYTyEKLLWTT protein stabilization; molecular association, regulation; ubiquitination; intracellular localization cell cycle regulation; carcinogenesis, induced; cell growth, induced; transcription, induced PKM(INDUCES) 22056988; 35697802 4 2 0 inhibits ubiquitination -Gapdh GAPDH Carbohydrate Metabolism - glycolysis and gluconeogenesis; EC 1.2.1.12; Oxidoreductase P16858 14433 6 F2|6 59.32 cM mouse K217-ac 474650 GAAKAVGkVIPELNG Gp_dh_C enzymatic activity, induced 27212436 1 7 1 induces glycolysis and memory T cell functions -H3f3b H3 iso3 DNA-binding P84244 15081 11|11 E2 mouse S28-p 455677 ATKAARKsAPSTGGV Histone activity, induced transcription, altered; cell growth, altered 15994958 50 18 0 -FADD FADD Adaptor/scaffold; Apoptosis Q13158 8772 11q13.3 human S194-p 447653 QNRSGAMsPMSWNSD intracellular localization; protein conformation cell cycle regulation; apoptosis, altered; carcinogenesis, altered; apoptosis, induced; apoptosis, inhibited 12702765; 12954630; 15001534; 15906275; 16061179; 18657552; 20890306; 21978935 15 28 0 apoptosis and necrosis -ETV6 Tel DNA-binding; Motility/polarity/chemotaxis; Oncoprotein; Transcription factor P41212 2120 12p13.2 human S213-p 451376 DNMIRRLsPAERAQG molecular association, regulation; activity, inhibited cell differentiation, altered; transcription, inhibited; cell growth, altered DNA(DISRUPTS) 15060146 1 37 2 -SMC3 SMC3 Cell cycle regulation; DNA repair, damage Q9UQE7 9126 10q25.2 human K105-ac 461824 LRRVIGAkKDQYFLD SMC_N protein stabilization; molecular association, regulation cell cycle regulation; DNA repair, induced; chromatin organization, altered; cell growth, induced; cytoskeletal reorganization DNA(INDUCES) 18614053; 20501661; 22101327; 22751501; 28847955; 29196537 7 10 180 regulates mitotic chromosome segregation and sister chromatid cohesion, ESCO2 KO has growth defects; Sister chromatid cohesion -POLR2A POLR2A EC 2.7.7.48; EC 2.7.7.6; Nucleotide Metabolism - purine; Nucleotide Metabolism - pyrimidine; Transcription initiation complex; Transferase P24928 5430 17p13.1 human S1616-p 450204 TPQSPSYsPTSPSYS RNA_pol_Rpb1_R molecular association, regulation; intracellular localization; enzymatic activity, inhibited; enzymatic activity, induced cell cycle regulation; DNA repair, induced; RNA splicing, altered; transcription, induced; transcription, altered; transcription, inhibited INTS11(INDUCES); TOP1(DISRUPTS); CTDSP1(INDUCES); CABIN1(INDUCES); SMN(INDUCES); UBN1(INDUCES); HIRA(INDUCES) DNA(INDUCES) 10995388; 11425311; 16641292; 17157258; 17259211; 18079403; 18757415; 20434984; 20457598; 20880846; 21070967; 22012619; 22195966; 23249733; 25470060; 25561469; 25620562; 26279188; 26527278; 26588990; 26700805; 27058666; 27068475; 34608337 81 4 0 PRC1 mediated repression is achieved by controlling transcriptional burst frequency -Hist3h2ba H2B DNA-binding D3ZNZ9 303175 10q22 rat K15-ac 458957 PAPKKGSkKAITKAQ Histone phosphorylation apoptosis, inhibited 20057502 8 9 468 inhibits phosphorylation at S14 -H3C1 H3 DNA-binding P68431 8350 6p22.2 human K23-ub 3932850 PRKQLATkAARKSAP Histone cell cycle regulation 25765655 1 5 99 regulation of DNA replication during S phase -CACYBP CACYBP Adaptor/scaffold; Ubiquitin conjugating system Q9HB71 27101 1q25.1 human S141-p 15343403 KPISVEGsSKKVKTD CS intracellular localization apoptosis, altered 20729913 1 0 0 -OPRL1 KOR-3 GPCR, family 1; Membrane protein, integral; Membrane protein, multi-pass; Receptor, GPCR P41146 4987 20q13.33 human S363-p 27150200 VALACKTsETVPRPA receptor internalization, induced; receptor desensitization, induced; phosphorylation signaling pathway regulation 23086955; 30914485 3 0 0 -MAD1L1 MAD1L1 Cell cycle regulation; Cytoskeletal Q9Y6D9 8379 7p22.3 human S598-p 18911590 AAASLPSsKEVAELK MAD molecular association, regulation cell cycle regulation Mad2(INDUCES) 29162720 1 1 0 -Notch1 Notch 1 Membrane protein, integral; Motility/polarity/chemotaxis; Oncoprotein; Receptor, misc.; Transcription factor Q01705 18128 2 A3|2 18.91 cM mouse K1785-ac 18899500 GEDSVGLkPLKNASD protein stabilization; ubiquitination 21499261 1 1 0 -Met Met EC 2.7.10.1; KINASE; Kinase, protein; Membrane protein, integral; Oncoprotein; Protein kinase, TK; Protein kinase, tyrosine (receptor) P16056 17295 6 A2|6 7.83 cM mouse S983-p 450188 PHLDRLVsARSVSPT enzymatic activity, inhibited 19595710 7 1 0 -LIMK2 LIMK2 EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, Ser/Thr (non-receptor); Protein kinase, TKL P53671 3985 22q12.2 human T494-p 467206 KATTKKRtLRKNDRK PK_Tyr_Ser-Thr protein stabilization; intracellular localization cell adhesion, induced 16820362; 22492986 2 0 0 -Npy1r NPY1R GPCR, family 1; Membrane protein, integral; Membrane protein, multi-pass; Receptor, GPCR P21555 29358 16p14 rat S359-p 2815300 STMHTDVsKTSLKQA receptor desensitization, altered; receptor internalization, altered 15576634 1 0 1 may be an artifact of the truncation mutants -SMAD1 SMAD1 DNA-binding; Transcription factor Q15797 4086 4q31.21 human K116-ub 1051003 CEFPFGSkQKEVCIN MH1 protein degradation 17963781 1 1 0 -Sqstm1 SQSTM1 Autophagy; Nuclear receptor co-regulator; Ubiquitin conjugating system Q64337 18412 11|11 B1.3 mouse S405-p 22264800 ESLSQMLsMGFSDEG UBA_5 exocytosis, inhibited; autophagy, induced; cytoskeletal reorganization; transcription, altered 28055010; 33528041; 36092812 30 7 0 -Gli2 GLI2 C2H2-type zinc finger protein; Oncoprotein; Transcription factor Q0VGT2 14633 1 E2.3|1 52.17 cM mouse K630-sm 25352004 CLHIKAIkTESSGLC molecular association, regulation transcription, inhibited HDAC5(INDUCES) 22549777 1 0 0 -CDC73 CDC73 Cell cycle regulation; Tumor suppressor Q6P1J9 79577 1q31.2 human K257-ub 41483948 FAILQSVkAREEGRA CDC73_N protein degradation; ubiquitination 35551175 1 3 0 -EIF5A2 EIF5A2 Q9GZV4 56648 3q26.2 human K85-ub 21173814 NMDVPNIkRNDYQLI eIF-5a protein degradation 35064108 1 10 0 regulate EMT, and may inhibit the metastasis of CRC -EPB41 EPB41 iso2 Cytoskeletal P11171-2 2035 1p35.3 human S679-p 467260 DKRLSTHsPFRTLNI SAB molecular association, regulation; intracellular localization cell cycle regulation NuMA-1(INDUCES); TUBA4A(INDUCES) 15525677 1 30 17 Also associates with tubulin and NuMA in vivo. Mutant EPB41 T60A-S679A abolishes localization to the mitotic spindle. -POLH POLH DNA repair, damage; EC 2.7.7.7; Transferase Q9Y253 5429 6p21.1 human K709-sm 1877365918 QTLESFFkPLTH___ intracellular localization; enzymatic activity, inhibited 32350109 1 1 0 -SGK2 SGK2 EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, AGC; Protein kinase, Ser/Thr (non-receptor) Q9HBY8 10110 20q13.12 human T193-p 456159 EPEDTTStFCGTPEY Pkinase transcription, inhibited 28911860 2 2 0 represses the PCK1 promoter -Nfatc2 NFAT1 DNA-binding; Transcription factor Q60591 18019 2 H3|2 88.91 cM mouse K684-sm 12057401 YHPVPAIkTEPSDEY sumoylation transcription, induced 15117942 1 0 0 Sumoylation of NFAT1-K897 -DDIT3 DDIT3 Autophagy; DNA-binding; Oncoprotein; Transcription factor P35638 1649 12q13.3 human S30-p 455503 EDLQEVLsSDENGGT protein degradation; ubiquitination; activity, inhibited transcription, inhibited 12876286; 27650555 2 0 0 -MAP1LC3B LC3B Autophagy; Microtubule-binding; Ubiquitin-like modifier; Vesicle Q9GZQ8 81631 16q24.2 human T50-p 37045604 QLPVLDKtKFLVPDH ATG8 molecular association, regulation autophagy, induced; autophagy, inhibited ATG7(DISRUPTS); NBR1(DISRUPTS); SQSTM1(DISRUPTS); STX17(DISRUPTS); FYCO1(DISRUPTS); ATG4B(DISRUPTS) 31857374; 34146484 3 1 0 -Slc12a3 NCCT Membrane protein, integral; Membrane protein, multi-pass; Transporter; Transporter, SLC family P55018 54300 19p13-p12 rat T48-p 4709842 SHLTHGStLYLRTFG AA_permease_N activity, induced 22966159 4 1 0 -SDC4 syndecan-4 Cell adhesion; Membrane protein, integral; Motility/polarity/chemotaxis P31431 6385 20q13.12 human Y180-p 474327 KKKDEGSyDLGKKPI Syndecan molecular association, regulation; intracellular localization; receptor recycling, altered endocytosis, induced; cell motility, induced syntenin(INDUCES) 23453597; 29109268 2 2 11 -Sgk1 SGK1 EC 2.7.11.1; KINASE; Kinase, protein; Motility/polarity/chemotaxis; Protein kinase, AGC; Protein kinase, Ser/Thr (non-receptor) Q9WVC6 20393 10|10 A3 mouse S422-p 448429 AEAFLGFsYAPPVDS Pkinase_C ubiquitination; phosphorylation; enzymatic activity, induced 34610303; 35058797 30 0 0 inhibits ENAC ubiquitination and degradation; induce AMPKA phosphorylation and inhibits AKT phosphorylation -MDC1 MDC1 Cell cycle regulation Q14676 9656 6p21.33 human T378-p 477989 ESQAGSDtDVEEGKA molecular association, regulation cell cycle regulation NBS1(INDUCES) 18678890 1 21 27 MDC1-NBS1 interaction regulates intra-S-phase checkpoint activation -Ptpa PPP2R4 EC 5.2.1.8; Motility/polarity/chemotaxis; Protein phosphatase, regulatory subunit P58389 110854 2 B|2 21.71 cM mouse K286-ub 573769710 SAVPSWSkVNQGLIR PTPA protein degradation; ubiquitination; methylation cytoskeletal reorganization 31160454 1 2 0 mediating the effects of UBE3A on spine morphology. -HIF1A HIF1A Autophagy; DNA-binding; Transcription factor Q16665 3091 14q23.2 human S643-p 470106 KILIASPsPTHIHKE activity, induced; protein stabilization; molecular association, regulation; intracellular localization apoptosis, inhibited; transcription, induced; transcription, altered HSPA9B(DISRUPTS); PIN1(INDUCES); Exportin-1(DISRUPTS) 16954218; 18687685; 26784107; 36825991 4 6 0 -Jun Jun Oncoprotein; Transcription factor P05627 16476 4 C5|4 43.34 cM mouse S63-p 447686 KNSDLLTsPDVGLLK Jun activity, induced; sumoylation; molecular association, regulation; acetylation cell differentiation, induced; cell growth, induced; apoptosis, induced; cell motility, altered; transcription, induced; transcription, altered; cell growth, altered HDAC3(DISRUPTS); EGR1(INDUCES); NFkB-p65(INDUCES) DNA(INDUCES) 10788439; 10851065; 12730213; 15122339; 16061693; 16964287; 18443042; 34962918; 36371601 133 43 4 -Kcnb1 Kv2.1 Channel, cation; Channel, ligand-gated; Channel, potassium; Membrane protein, integral; Membrane protein, multi-pass P15387 25736 3q42 rat S719-p 473557 LLDKPVLsPESSIYT activity, inhibited 16917065 4 3 0 -EGFR EGFR EC 2.7.10.1; KINASE; Kinase, protein; Membrane protein, integral; Oncoprotein; Protein kinase, TK; Protein kinase, tyrosine (receptor) P00533 1956 7p11.2 human K867-ub 1065305 KLLGAEEkEYHAEGG PK_Tyr_Ser-Thr receptor recycling, inhibited; protein degradation; protein stabilization 16543144; 17940017; 32669362 3 6 0 SMURF2-UBE2D1 protein?protein interaction affects mutant EGFR levels -AIRE AIRE Transcription factor O43918 326 21q22.3 human T68-p 1191300 ALLSWLLtQDSTAIL HSR protein degradation; molecular association, regulation; ubiquitination transcription, induced FBXO3(INDUCES) 17997173; 27365398 3 1 0 -NFE2 NF-E2 Cytoskeletal; DNA-binding; Transcription factor Q16621 4778 12q13.13 human K234-ub 11489905 ERRALAMkIPFPTDK protein degradation; ubiquitination transcription, inhibited 19966288 1 0 0 -CALD1 Caldesmon Actin-binding P12957 373965 chicken Y27-p 450224 LEAERLSyQRNDDDE molecular association, regulation SHC1(INDUCES) 10559276 1 2 13 -Slc24a2 SLC24A2 Membrane protein, integral; Membrane protein, multi-pass; Transporter; Transporter, SLC family O54701 84550 5q32 rat T476-p 471067 SLSWPSNtRKQITFL activity, induced 17038313 1 0 0 Mutation to alanine of T476 and either T166 or S504 (or possibly both) eliminates PDBu-induced enhancement (PIE) on the Na(+)/Ca(2+)+K(+) exchanger. -ZNF322 ZNF322A C2H2-type zinc finger protein; Transcription factor Q6U7Q0 79692 6p22.2 human T262-p 10990183 IVHQRVHtGEKPYKC activity, induced; protein stabilization carcinogenesis, induced; cell motility, induced; cell growth, induced; transcription, induced 31399647 1 5 1 -SIKE1 SIKE Cell adhesion Q9BRV8 80143 1p13.2 human S185-p 28076410 KELRELLsISSESLQ SIKE molecular association, regulation TBK1(DISRUPTS) 23649622 1 1 0 decreases inhibitory activity of SIKE (induces IRF3 phosphorylation) -VIM Vimentin Cytoskeletal; Motility/polarity/chemotaxis P08670 7431 10p13 human S5-p 471086 ___MSTRsVSSSSYR cell motility, altered 19291697 3 10 3 -HMGA1 HMGA1 DNA-binding P17096 3159 6p21.31 human K65-ac 458952 RGRPKGSkNKGAAKT AT_hook molecular association, regulation transcription, inhibited NFkB-p100(DISRUPTS) DNA(DISRUPTS) 11498590; 9809067 4 3 0 disrupts HMGA1/NF-kB cooperative complex and IFNB enhanceosome, prevents post induction turnoff in virus-induced ttanscription -Osbpl3 OSBPL3 iso3 Endoplasmic reticulum D3Z194 71720 6|6 B2.3 mouse S303-p 3212433 GPVRLHSsNPNLSTL apoptosis, inhibited 31509750 1 49 12 inhibits insulin secretion -REST REST C2H2-type zinc finger protein; Cell development/differentiation; DNA-binding; Transcription factor Q13127 5978 4q12 human S1030-p 37042902 MSEGSDDsGLHGARP protein degradation; ubiquitination carcinogenesis, induced; cell growth, induced 25453754; 29156689 2 1 0 -TNFAIP3 TNFAIP3 Apoptosis; DEUBIQUITINASE; EC 3.4.19.12; Protease; UBIQUITIN LIGASE; Ubiquitin conjugating system; Ubiquitin ligase P21580 7128 6q23.3 human T625-p 22778303 PENKGFCtLCFIEYR ubiquitination 26649818 1 1 18 cleavage of K63-linked tetraubiquitin ( all 4 sites or S381 alone), enhances ZnF4-mediated substrate ubiquitination -STAM2 STAM2 Adaptor/scaffold; Motility/polarity/chemotaxis O75886 10254 2q23.3 human Y374-p 449671 EAPVYSVySKLHPPA molecular association, regulation UBE2D2(DISRUPTS) 18626516 1 26 355 -LEF1 LEF-1 DNA-binding; Transcription factor Q9UJU2 51176 4q25 human S61-p 471385 KSSLVNEsEIIPASN CTNNB1_binding molecular association, regulation transcription, induced CTNNB1(INDUCES) 17113388 1 0 0 -Ctnnb1 CTNNB1 Actin-binding; Cell adhesion; Motility/polarity/chemotaxis; Nuclear receptor co-regulator; Oncoprotein; Transcription factor Q02248 12387 9 F4|9 72.19 cM mouse S45-p 447488 GATTTAPsLSGKGNP protein degradation; ubiquitination; intracellular localization transcription, altered 36989576; 9233789 57 7 0 -RBM17 RBM17 RNA splicing; RNA-binding; Spliceosome Q96I25 84991 10p15.1 human S266-p 27459081 QGLSTALsVEKTSKR G-patch molecular association, regulation; phosphorylation RNA splicing, inhibited; cell motility, induced RNA(DISRUPTS) 23519612 1 6 0 induced cell invasion, enhanced Cortactin phosphorylation at ERK-dependent sites -PDGFRA PDGFRA EC 2.7.10.1; KINASE; Kinase, protein; Membrane protein, integral; Oncoprotein; Protein kinase, TK; Protein kinase, tyrosine (receptor) P16234 5156 4q12 human Y731-p 448646 SFENNGDyMDMKQAD PK_Tyr_Ser-Thr molecular association, regulation PIK3R1(INDUCES) 11818394 2 6 31 -Nr2c2 NR2C2 DNA-binding; Nuclear receptor; Transcription factor P49117 22026 6|6 D1 mouse S19-p 467308 STDSAVAsPQRIQIV activity, inhibited transcription, altered 16887930 1 21 0 -WWTR1 TAZ Oncoprotein; Transcription, coactivator/corepressor Q9GZV5 25937 3q25.1 human S311-p 1244614 PYHSREQsTDSGLGL protein degradation; ubiquitination 22078877 3 1 8 -CENPT CENPT DNA replication F1NPG5 chicken T184-p 31870052 GSVMAPDtVEKRGLL CENP-T_N molecular association, regulation SPC25(INDUCES); SPBC24(INDUCES) 30420662 1 1 0 Fluorescence polarization, phospho-mimetic showed 65-fold increased affinity -PKN1 PKN1 EC 2.7.11.13; KINASE; Kinase, protein; Protein kinase, AGC; Protein kinase, Ser/Thr (non-receptor) Q16512 5585 19p13.12 human S916-p 452442 TGEAPTLsPPRDARP Pkinase_C enzymatic activity, induced carcinogenesis, induced; cell motility, induced; cell growth, induced 31981797 1 50 79 induces anchorage-independent cell growth -Grip1 GRIP1 Adaptor/scaffold P97879 84016 7q22 rat T956-p 480120 SQTTRSNtLPSDVGR molecular association, regulation cytoskeletal reorganization 14-3-3 beta(INDUCES); KIF5B(DISRUPTS) 24576423 1 18 24 interaction leads to releasing of GRIP1 from the kinesin-1 motor complex, increase dendritic arborization -DRD2 DRD2 iso2 GPCR, family 1; Membrane protein, integral; Membrane protein, multi-pass; Receptor, GPCR P14416-2 1813 11q23.2 human S325-p 467255 PNGKTRTsLKTMSRR 7tm_1 receptor desensitization, induced 23082996 2 0 0 PKC mediated receptor desensitization -FUS hnRNP P2 DNA-binding; Nuclear receptor co-regulator; Oncoprotein; RNA splicing; RNA-binding; SUMO LIGASE P35637 2521 16p11.2 human T338-p 1878186708 GKLKGEAtVSFDDPP molecular association, regulation hnRNP P2(DISRUPTS) 35753345 1 1 0 -HSP90AA1 HSP90A Chaperone; Heat shock protein P07900 3320 14q32.31 human K100-ac 2884402 DTGIGMTkADLINNL HATPase_c molecular association, regulation carcinogenesis, induced; exocytosis, induced CHIP(DISRUPTS); TEBP(DISRUPTS); HSP70(DISRUPTS); MMP2(INDUCES); HSP40(DISRUPTS) 18559531 1 2 1 -JAK3 JAK3 EC 2.7.10.2; KINASE; Kinase, protein; Protein kinase, TK; Protein kinase, tyrosine (non-receptor) P52333 3718 19p13.11 human Y904-p 2197001 SLRLVMEyLPSGCLR PK_Tyr_Ser-Thr phosphorylation; enzymatic activity, induced 18250158 1 0 0 required for STAT5A Y694 phosphorylation and its further transcriptional activation -PRPS1 PRPS1 Carbohydrate Metabolism - pentose phosphate pathway; EC 2.7.6.1; Kinase, other; Nucleotide Metabolism - purine P60891 5631 Xq22.3 human S103-p 56655989 RQDKKDKsRAPISAK Pribosyltran_N enzymatic activity, induced cell cycle regulation; carcinogenesis, induced; cell growth, induced; transcription, induced 31253668 1 2 0 increase CCND1 expression -BUB1B BUB1B EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, Other; Protein kinase, Ser/Thr (non-receptor); Tumor suppressor O60566 701 15q15.1 human T1008-p 7652107 LNANDEAtVSVLGEL enzymatic activity, induced cell cycle regulation 17376779 2 0 0 facilitates chromosome alignment during prometaphase -SH3GL1 endophilin A2 Oncoprotein; Vesicle Q99961 6455 19p13.3 human Y315-p 450745 QPSCKALyDFEPEND SH3_1 molecular association, regulation DYN1(DISRUPTS) 16054026 2 2 3 -NR1D1 NR1D1 Nuclear receptor; Transcription factor P20393 9572 17q21.1 human S55-p 471091 CPTYFPPsPTGSLTQ protein stabilization 16484495 1 0 2 -KLF13 KLF13 C2H2-type zinc finger protein; DNA-binding Q9Y2Y9 51621 15q13.3 human K225-ac 460601 YRTHTGEkKFSCPIC molecular association, regulation transcription, induced DNA(DISRUPTS) 12758070 1 0 3 -NR5A1 STF-1 Nuclear receptor; Transcription, coactivator/corepressor Q13285 2516 9q33.3 human K119-ub 11489901 QIRANGFkLETGPPM molecular association, regulation transcription, induced PITX1(INDUCES) 19995909 1 0 0 -GJA1 GJA1 Channel, misc.; Membrane protein, integral; Membrane protein, multi-pass; Motility/polarity/chemotaxis P17302 2697 6q22.31 human S262-p 450694 SPAKDCGsQKYAYFN molecular association, regulation; intracellular localization; protein conformation cell cycle regulation; endocytosis, induced; cell growth, inhibited; apoptosis, inhibited; cell growth, altered KCNJ8(INDUCES); KCNJ8(DISRUPTS); CLTA(INDUCES) 15605363; 16718370; 22737133; 22960107; 23828237; 24492000; 24815185 29 5 4 -WAC WAC Adaptor/scaffold Q9BTA9 51322 10p12.1|10p12.1-p11.2 human T482-p 469446 SSQPKVStPVVKQGP molecular association, regulation; phosphorylation cell cycle regulation PLK1(INDUCES) 30021153 1 5 18 -Pou3f2 Oct7 DNA-binding; Motility/polarity/chemotaxis; Transcription factor P31360 18992 4 A3|4 9.73 cM mouse S362-p 486486 RKRKKRTsIEVSVKG Homeodomain molecular association, regulation cell cycle regulation; cell motility, induced; transcription, induced; transcription, inhibited DNA(DISRUPTS) 22290434; 34168041 3 1 0 -TBX21 TBX21 DNA-binding; Transcription factor Q9UL17 30009 17q21.32 human Y266-p 20583306 VLQSLHKyQPRLHIV T-box molecular association, regulation cell differentiation, altered; cell growth, induced; transcription, induced DNA(INDUCES) 21690296 1 0 0 -PRPS1 PRPS1 Carbohydrate Metabolism - pentose phosphate pathway; EC 2.7.6.1; Kinase, other; Nucleotide Metabolism - purine P60891 5631 Xq22.3 human S180-p 18014261 GGAKRVTsIADRLNV protein conformation; activity, inhibited cell growth, inhibited 29074724 1 5 0 tumor cell growth inhibited; converts PRPS1/2 hexamers to monomers -RUNX3 AML2 DNA-binding; Transcription factor Q13761 864 1p36.11 human T151-p 6097702 SGRGKSFtLTITVFT Runt protein stabilization; intracellular localization cell cycle regulation; transcription, altered 18767071 1 1 0 -NR3C1 GR DNA-binding; Mitochondrial; Nuclear receptor; Transcription factor P04150 2908 5q31.3 human Y30-p 23111235 RGDVMDFyKTLRGGA GCR molecular association, regulation; intracellular localization; protein conformation DNAJC7(DISRUPTS) 30718983 1 0 3 phosphorylation of this site blocks an interaction of N-terminal (NTS) domain of GR with its C-terminal domain (LBD) -SKIL SKIL Cell development/differentiation; Transcription, coactivator/corepressor P12757 6498 3q26.2 human K440-ub 3144805 SISRQSEkAHSSGKL protein degradation signaling pathway regulation 11691834 1 0 0 TGF-beta signaling -Egfr EGFR EC 2.7.10.1; KINASE; Kinase, protein; Membrane protein, integral; Oncoprotein; Protein kinase, TK; Protein kinase, tyrosine (receptor) Q01279 13649 11 A2|11 9.41 cM mouse Y1018-p 448055 DVVDADEyLIPQQGF apoptosis, inhibited 16123117 45 7 12 -Plcb3 PLCB3 Carbohydrate Metabolism - inositol phosphate; EC 3.1.4.11; Phospholipase Q99JE6 29322 1q43 rat S26-p 448449 VETLRRGsKFIKWDE PH_14 enzymatic activity, inhibited 11278298 1 0 0 -STIM1 STIM1 Calcium-binding; Endoplasmic reticulum; Membrane protein, integral Q13586 6786 11p15.4 human S257-p 468872 GLHRAEQsLHDLQER protein conformation; activity, inhibited cytoskeletal reorganization; signaling pathway regulation 31381180 2 51 2 -Npr2 ANPB EC 4.6.1.2; Guanylyl cyclase; KINASE; Kinase, protein; Lyase; Membrane protein, integral; Nucleotide Metabolism - purine; Protein kinase, RGC; Protein kinase, dual-specificity (receptor); Receptor, misc. P16067 116564 5q22 rat S518-p 450025 AGSRLTLsLRGSSYG PK_Tyr_Ser-Thr activity, induced 9624142 2 1 0 -TRPV4 TRPV4 Channel, cation; Membrane protein, integral; Membrane protein, multi-pass Q9HBA0 59341 12q24.11 human S824-p 4777181 LRRDRWSsVVPRVVE activity, induced; molecular association, regulation; intracellular localization STIM1(DISRUPTS) 19661060; 25972993; 32186440 8 3 0 -Abi1 Abi-1 Adaptor/scaffold; Motility/polarity/chemotaxis Q8CBW3 11308 2 A3|2 15.18 cM mouse Y428-p 3589548 IEKVVAIyDYTKDKD SH3_1 molecular association, regulation cell adhesion, altered Abl(INDUCES) 21320496 1 4 4 enhances cell adhesion in Bcr-Abl expressing cells; induces the catalytic activity of c-Abl in vitro -CASP3 CASP3 Apoptosis; EC 3.4.22.56; Motility/polarity/chemotaxis; Protease P42574 836 4q35.1 human S150-p 450984 FRGDRCRsLTGKPKL Peptidase_C14 molecular association, regulation; activity, inhibited neural plasticity; apoptosis, inhibited GluR1(DISRUPTS) 14970175; 33176141 3 0 0 -GJA1 GJA1 Channel, misc.; Membrane protein, integral; Membrane protein, multi-pass; Motility/polarity/chemotaxis P17302 2697 6q22.31 human S372-p 465460 SRASSRAsSRPRPDD protein conformation 23828237 5 6 1 -EEF1A1 EEF1A1 Nucleolus; Translation; Translation elongation P68104 1915 6q13 human K55-m1 2584348 EMGKGSFkYAWVLDK GTP_EFTU molecular association, regulation L3MBTL iso4(INDUCES) 23583077 1 4 46 -Nr4a1 Nur77 Apoptosis; DNA-binding; Nuclear receptor P12813 15370 15|15 F1 mouse S151-p 1255792405 STPNFQPsQLSPWDG protein degradation; ubiquitination 30224829 1 0 0 regulates TNF-a mediated IL-6 production -NBN NBS1 Cell cycle regulation; DNA repair, damage O60934 4683 8q21.3 human K504-ac 487511 TPSLWKNkEQHLSEN phosphorylation cell cycle regulation; apoptosis, induced 17612497 2 1 0 inhibits phosphorylation at S343 -AIRE AIRE Transcription factor O43918 326 21q22.3 human S156-p 1191301 RGTASPGsQLKAKPP protein degradation; molecular association, regulation; ubiquitination transcription, induced FBXO3(INDUCES) 17997173; 27365398 3 1 0 -H2ac4 H2A.1 DNA-binding C0HKE1 319172 13|13 A3.1 mouse K5-ac 458908 ___SGRGkQGGKARA Histone protein degradation cell cycle regulation 31437213 12 9 145 Arrested round spermatids containing PSMA8 are involved in acetyation-dependent degradation of histones during prophase I. -H2AX H2AX DNA repair, damage; DNA-binding; Helicase P16104 3014 11q23.3 human K13-ub 55610203 TGGKARAkAKSRSSR Histone intracellular localization DNA repair, induced; carcinogenesis, inhibited; cell growth, inhibited 22980979; 27345151; 32213544 4 0 0 recruitment of 53BP1 to DNA break sites ; regulates recruitment of DNA repair factors to DSB sites via autophagy-regulated pathway -Swap70 SWAP-70 GEF; GEF, Rac/Rho Q6A028 20947 7 E3|7 57.7 cM mouse Y517-p 450716 RKQALEQyEGVKKKL molecular association, regulation cell motility, altered 21123826 1 2 134 critical for cell polarization; reduces SWAP-70 binding to F-actin -RPA2 RFA2 DNA replication P15927 6118 1p35.3 human S23-p 448337 GAGGYTQsPGGFGSP molecular association, regulation; intracellular localization cell cycle regulation; DNA repair, induced WRN(INDUCES) 17928296; 19671522; 20154705; 21107010; 26237679 7 3 0 -NRL NRL DNA-binding; Transcription factor P54845 4901 14q11.2-q12 human K20-sm 14988615 VNDFDLMkFEVKREP cell differentiation, induced; transcription, induced 20551322 1 0 0 -CSF3R GCSFR Membrane protein, integral; Receptor, cytokine Q99062 1441 1p34.3 human Y727-p 451101 LPTLVQTyVLQGDPR molecular association, regulation STAT3(INDUCES) 16493051 4 0 0 -TPD52 TPD52 Calcium-binding; Endoplasmic reticulum P55327 7163 8q21.13 human K163-ac 1881321500 SVGSVITkKLEDVKN molecular association, regulation; activity, inhibited carcinogenesis, inhibited; cell growth, inhibited; autophagy, inhibited HSC70(DISRUPTS) 34034634 1 1 0 inhibits CMA (chaperone-mediated autophagy ) -CD274 PD-L1 Membrane protein, integral Q9NZQ7 29126 9p24.1 human T285-p 1876861204 NSKKQSDtHLEET__ protein stabilization; molecular association, regulation carcinogenesis, induced SPOP(DISRUPTS) 35385574 1 1 0 inhibits ubiquitination -MVB12B FAM125B Vesicle Q9H7P6 89853 9q33.3 human K264-ub 15167002 VPFMISEkFSCVPES DUF2464 intracellular localization 20654576 1 0 0 -CDKN1B p27Kip1 Cell cycle regulation; Inhibitor; Oncoprotein; Protein kinase, regulatory subunit P46527 1027 12p13.1 human Y89-p 456819 GSLPEFYyRPPRPPK molecular association, regulation; intracellular localization; activity, inhibited cell cycle regulation CDK2(INDUCES); CDK4(INDUCES) 16195327; 17908796 8 0 0 When phosphorylated at Y88 or Y89, p27 able to bind but was unable to inhibit cdk4 in vitro and in vivo. -Ptk6 Brk EC 2.7.10.2; KINASE; Kinase, protein; Protein kinase, TK; Protein kinase, tyrosine (non-receptor) Q64434 20459 2 H4|2 103.62 cM mouse Y447-p 450276 KLTGITRyENLV___ enzymatic activity, inhibited RNA stability, altered KHDRBS1(INDUCES) 10913193 6 16 367 -CAMK2D CAMK2D EC 2.7.11.17; KINASE; Kinase, protein; Protein kinase, CAMK; Protein kinase, Ser/Thr (non-receptor) Q13557 817 4q26 human T287-p 450982 SMMHRQEtVDCLKKF molecular association, regulation; intracellular localization; enzymatic activity, induced Calmodulin(INDUCES); RNF8(INDUCES) 19884317; 34371035; 37468549 15 32 148 -HIF1A HIF1A Autophagy; DNA-binding; Transcription factor Q16665 3091 14q23.2 human K389-ac 3080901 DTSSLFDkLKKEPDA molecular association, regulation DNA(INDUCES) 18574470 1 0 0 -PLA2G4A PLA2G4A EC 3.1.1.4; EC 3.1.1.5; Lipid Metabolism - alpha-linolenic acid; Lipid Metabolism - arachidonic acid; Lipid Metabolism - ether lipid; Lipid Metabolism - glycerophospholipid; Lipid Metabolism - linoleic acid; Phospholipase P47712 5321 1q31.1 human S727-p 447599 RQNPSRCsVSLSNVE molecular association, regulation; intracellular localization; enzymatic activity, induced ANXA2(DISRUPTS); S100A10(DISRUPTS) Other(INDUCES) 18065419 8 33 0 activation and localization change (binding membranes) through release of ANXA2 -DACT1 DACT1 Adaptor/scaffold Q9NYF0 51339 14q23.1 human S237-p 18159801 GAVCRSLsTPQFNSL Dapper molecular association, regulation carcinogenesis, altered; cell growth, altered 14-3-3 beta(INDUCES) 21262972 1 1 0 ; modulates Wnt signaling -CFTR CFTR Channel, chloride; EC 3.6.3.49; Hydrolase; Membrane protein, integral; Membrane protein, multi-pass; Transporter; Transporter, ABC family P13569 1080 7q31.2 human S660-p 449979 FSAERRNsILTETLH CFTR_R activity, induced; molecular association, regulation; enzymatic activity, inhibited; protein conformation CFTR(INDUCES) 11053017; 14602047; 1716180; 25330774 9 8 0 S660A mutant is constitutively active; potentiates channel function -CCP110 CP110 Cell cycle regulation O43303 9738 16p12.3 human T566-p 35546004 NTRQQMDtPMVSCGN intracellular localization cell cycle regulation 12361598 1 0 0 -CLEC6A dectin-2 Membrane protein, integral Q6EIG7 93978 12p13.31 human K12-ub 56836804 QQPQSTEkRGWLSLR protein degradation 27432944 2 0 0 negative regulation of antifungal immune response -Dzip1 DZIP1 C2H2-type zinc finger protein Q8BMD2 66573 14|14 E4 mouse S665-p 13907506 TKTPPFSsEEEPDEE transcription, induced; signaling pathway regulation 21878643 1 0 0 involved in Gli1 nad Gli3 turnover pathway -Pdlim5 PDLIM5 Adaptor/scaffold Q8CI51 56376 3|3 H1 mouse S177-p 38546304 TPLHLSAsGLHVSAN molecular association, regulation cytoskeletal reorganization; cell motility, inhibited ARHGEF6(DISRUPTS) 25635515; 34368251 2 0 0 attenuates lamellipodia formation; decrease lamellipodia formation -MAP2K1 MEK1 EC 2.7.12.2; KINASE; Kinase, protein; Protein kinase, STE; Protein kinase, dual-specificity (non-receptor) Q02750 5604 15q22.31 human S212-p 448283 KLCDFGVsGQLIDSM Pkinase enzymatic activity, inhibited 12506122 5 2 3 -ZFP36L1 BRF1 Transcription factor Q07352 677 14q24.1 human S203-p 470146 PRLQHSFsFAGFPSA protein stabilization; molecular association, regulation cell growth, inhibited; transcription, altered; RNA stability, altered 14-3-3 beta(INDUCES) 17030608; 18326031; 26280535 3 1 20 inhibits BRF1-dependent AMD ( ARE-mediated mRNA decay); for its physiological effect phosphorylation of this site cooperates with phosphorylation of S90 and S92; senescence-associated secretory phenotype (SASP) -MITF MITF iso9 DNA-binding; Oncoprotein; Transcription factor O75030-9 4286 3p13 human S409-p 450265 KTSSRRSsMSMEETE DUF3371 activity, induced; protein degradation transcription, induced 10673502; 21749389 8 5 0 An MITF double mutant in which S73 and S409 are converted to alanines is both extremely stable and transcriptionally inactive. -Pde6g PDE6G EC 3.1.4.35; Nucleotide Metabolism - purine; Phosphodiesterase P09174 18588 11 E2|11 84.14 cM mouse T35-p 450149 PKFKQRQtRQFKSKP PDE6_gamma protein conformation; enzymatic activity, induced 17138607; 18305241 5 0 0 -KIF2A KIF2A Microtubule-binding; Motor O00139 3796 5q12.1 human S157-p 2150904 GPPSRRKsNCVKEVE intracellular localization cell cycle regulation; cytoskeletal reorganization 23960144 1 1 14 -CYLD CYLD DEUBIQUITINASE; EC 3.4.19.12; Protease; Tumor suppressor; Ubiquitin conjugating system; Ubiquitin-specific protease Q9NQC7 1540 16q12.1 human S444-p 12173910 PLSLSAQsVMEELNT CYLD_phos_site ubiquitination 15870263 2 1 0 induces ubiquitination of TRAF2 -REST REST C2H2-type zinc finger protein; Cell development/differentiation; DNA-binding; Transcription factor Q13127 5978 4q12 human S864-p 453739 TEDLSPPsPPLPKEN protein degradation; molecular association, regulation; protein conformation cell differentiation, inhibited; transcription, induced BTRC(INDUCES); RCOR1(DISRUPTS); PIN1(INDUCES) 25197063; 30217818 2 17 0 -Ahr AHR DNA-binding; Transcription factor P41738 25690 6q16 rat Y320-p 455230 LCNKGSGyQFIHAAD PAS_3 transcription, altered 15451023 2 0 0 -GYS1 GYS1 Carbohydrate Metabolism - starch and sucrose; EC 2.4.1.11; Transferase P13834 100008660 rabbit S657-p 449790 RHSSPHQsEDEEEPR Glycogen_syn enzymatic activity, inhibited; phosphorylation 10909964; 6819160; 7929255 14 31 20 simultaneous mutation of both NH2- and COOH-terminal sites was necessary to cause substantial increases in the activity ratio.; primes protein for GSK3 phosphorylation -RNF41 RNF41 EC 6.3.2.-; EC 6.3.2.19; Ligase; UBIQUITIN LIGASE; Ubiquitin conjugating system; Ubiquitin ligase Q9H4P4 10193 12q13.3 human S254-p 29675602 IENAHERsWPQGLAT USP8_interact cytoskeletal reorganization 24259665 1 0 0 required for epithelial cells to establish cell polarity, laminin-111 deposition on the basal surface of epithelial cells -Nlgn2 NLGN2 Membrane protein, integral Q69ZK9 216856 11|11 B3 mouse S714-p 487169 ELRCRRLsPPGGSGS molecular association, regulation; intracellular localization; protein conformation gephyrin(INDUCES); PIN1(INDUCES) 25297980 3 9 0 immobilization of GABAR at inhibitory synapses -HNF4A HNF4 alpha DNA-binding; Nuclear receptor; Transcription factor P41235 3172 20q13.12 human S142-p 458368 DRISTRRsSYEDSSL molecular association, regulation transcription, inhibited; signaling pathway regulation DNA(DISRUPTS) 21598922 4 4 6 PKA signaling pathway -GUCY2C GUCY2C EC 4.6.1.2; Guanylyl cyclase; KINASE; Kinase, protein; Lyase; Membrane protein, integral; Nucleotide Metabolism - purine; Protein kinase, RGC; Protein kinase, dual-specificity (receptor); Receptor, misc. P55204 397193 pig S1052-p 451300 RKPTRVAsYKKGTLE activity, induced 8797807 1 1 0 PMA treatment caused additional STa-mediated guanylyl-cyclase activation compared to control. -Piwil1 PIWIL1 Membrane protein, peripheral Q9JMB7 57749 5 G1.3|5 67.86 cM mouse R49-m1 9859902 TEGDLVGrGRQRGMV GAGE molecular association, regulation; intracellular localization TDRKH(INDUCES); TDRD9(INDUCES); TDRD1(INDUCES); TDRD6(INDUCES); TDRD7(INDUCES) 19584108 1 1 0 -FPR2 FPR2 GPCR, family 1; Membrane protein, integral; Membrane protein, multi-pass; Motility/polarity/chemotaxis; Receptor, GPCR P25090 2358 19q13.41 human T335-p 19075302 DSAPTNDtAANSASP receptor desensitization, induced; phosphorylation 21543323 1 0 0 -Atp5f1c ATP5C EC 3.6.3.14; Energy Metabolism - oxidative phosphorylation; Hydrolase; Mitochondrial Q91VR2 11949 2|2 A1 mouse K55-ac 11322790 MKMVAAAkYARAERE ATP-synt enzymatic activity, inhibited 36160705 1 5 0 K-55 site exhibited decreased enzymatic activity and ATP synthesis after irradiation -FLT3 FLT3 EC 2.7.10.1; KINASE; Kinase, protein; Membrane protein, integral; Oncoprotein; Protein kinase, TK; Protein kinase, tyrosine (receptor) P36888 2322 13q12.2 human Y572-p 466345 KYKKQFRyESQLQMV molecular association, regulation GRB10(INDUCES) 23246379 2 0 0 -SHC4 SHC4 Adaptor/scaffold Q6S5L8 399694 15q21.1 human Y375-p 3654471 EREDHEYyNEIPGKQ molecular association, regulation SHP-2(INDUCES) 28213521 1 2 4 -PARN PARN EC 3.1.13.4; Nucleolus; RNA-binding; Ribonuclease O95453 5073 16p13.12 human S557-p 483559 NHYYRNNsFTAPSTV cell cycle regulation 20932473 1 30 53 -Pde4a PDE4A EC 3.1.4.53; Nucleotide Metabolism - purine; Phosphodiesterase P54748 25638 8q13 rat S147-p 3189445 SFLYRSDsDYDMSPK molecular association, regulation; protein conformation AIP(DISRUPTS); DISC1(DISRUPTS) 21323643 1 10 2 -RPL11 RPL11 Motility/polarity/chemotaxis; Nucleolus; Ribosomal; Translation P62913 6135 1p36.11 human K8-ne 12067601 MAQDQGEkENPMREL protein stabilization; intracellular localization 19713960 1 0 0 -Atf2 ATF-2 ACETYLTRANSFERASE; C2H2-type zinc finger protein; EC 2.3.1.48; Transcription factor P16951 11909 2|2 C3 mouse T53-p 448225 IVADQTPtPTRFLKN protein stabilization carcinogenesis, induced; cell growth, induced; transcription, induced; transcription, altered 10521481; 21706057; 34346771 53 54 37 -SMN1 SMN RNA processing; RNA-binding Q16637 6606 5q13.2 human S180-p 27459811 SRSPGNKsDNIKPKS SMN molecular association, regulation; intracellular localization coilin(INDUCES) 24602413 1 4 0 -DES desmin Cytoskeletal; Motility/polarity/chemotaxis P17661 1674 2q35 human T77-p 449616 RASRLGTtRTPSSYG Filament_head cytoskeletal reorganization 12686604 1 0 0 Mutated desmin sites showed failure of desmin filaments to segregate into daughter cells. -PML PML iso4 Nucleolus; Oncoprotein; SUMO LIGASE; SUMO conjugating system; SUMO ligase; Transcription factor; Tumor suppressor; Ubiquitin conjugating system P29590-4 5371 15q24.1 human S38-p 451470 EGRQPSPsPSPTERA protein stabilization apoptosis, altered 15093545 2 11 0 Phosphorylation of PML is associated with enhanced sumoylation and apoptosis induced by As2O3. -DUSP4 DUSP4 EC 3.1.3.16; EC 3.1.3.48; PHOSPHATASE; Protein phosphatase, dual-specificity Q13115 1846 8p12 human S391-p 15412246 LHSPITTsPSC____ protein stabilization 25204653 2 1 2 -Tnip1 TNIP1 Transcription regulation Q9WUU8 57783 11|11 B1.3 mouse S83-p 1876350208 TSAPSLVsFDDLAEL protein degradation; molecular association, regulation; activity, inhibited autophagy, induced; signaling pathway regulation LC3A(INDUCES) 35213742 1 1 0 inhibits NF-kB activation and signaling pathway -FOXO3 FOXO3A Autophagy; DNA-binding; Oncoprotein; Transcription factor O43524 2309 6q21 human S344-p 2058401 QDDDAPLsPMLYSSS protein degradation; molecular association, regulation; activity, inhibited cell growth, altered MDM2(INDUCES) 18204439 2 2 0 promotes tumorigenicity -IRF3 IRF3 DNA-binding; Transcription factor Q14653 3661 19q13.33 human S339-p 2255400 FTEGSGRsPRYALWF IRF-3 protein degradation; molecular association, regulation transcription, inhibited; transcription, altered IRF3(INDUCES); PIN1(INDUCES); CBP(INDUCES) 16699525; 18272581; 35948267 4 2 0 -ATR ATR EC 2.7.11.1; KINASE; Kinase, protein; Membrane protein, integral; Protein kinase, Ser/Thr (non-receptor); Protein kinase, atypical Q13535 545 3q23 human T1578-p 22561302 SDLCQLStQTVFSML cell cycle regulation; cell growth, induced 21908846 1 1 0 -DNMT1 DNMT1 Amino Acid Metabolism - cysteine and methionine; Cell development/differentiation; EC 2.1.1.37; METHYLTRANSFERASE; Methyltransferase; Methyltransferase, DNA; Transcription regulation P26358 1786 19p13.2 human K1349-ac 25171003 SVVVDDKkFVSNITR DNA_methylase enzymatic activity, inhibited cell cycle regulation 21947282 1 1 0 -Cdk18 CDK18 Cell cycle regulation; EC 2.7.11.22; KINASE; Kinase, protein; Motility/polarity/chemotaxis; Protein kinase, CMGC; Protein kinase, Ser/Thr (non-receptor) Q04899 18557 1|1 E4 mouse S12-p 2192675 KNFKRRLsLSVPRPE phosphorylation; enzymatic activity, induced cytoskeletal reorganization 24831015 1 18 8 inhibits cofilin phosphorylation -ADD2 ADD2 Cytoskeletal; Motility/polarity/chemotaxis P35612 119 2p13.3 human S713-p 449802 KKKFRTPsFLKKSKK protein degradation; intracellular localization; phosphorylation cytoskeletal reorganization 16116087; 26639316; 9679146 8 58 159 -SLC2A4 GLUT4 Membrane protein, integral; Membrane protein, multi-pass; Transporter; Transporter, SLC family P14672 6517 17p13.1 human S274-p 478418 LERERPLsLLQLLGS Sugar_tr activity, induced 17382906 1 0 0 activation of glucose transport -Syn1 SYN1 Vesicle P09951 24949 Xq11 rat S566-p 456356 PQATRQAsISGPAPP phosphorylation 10386995 3 11 6 in the presnce of two GlcNAcs CaM Kinase II activity had a 66% increase in KM with no effect on Vmax or Kcat -Arrb2 ARRB2 Adaptor/scaffold P29067 25388 10q24 rat T383-p 455373 EFDTNYAtDDDIVFE molecular association, regulation; protein conformation signaling pathway regulation ERK2(INDUCES); ERK1(INDUCES) 28169830 5 3 2 -HIF1A HIF1A Autophagy; DNA-binding; Transcription factor Q16665 3091 14q23.2 human K11-ac 25126715 AGGANDKkKISSERR protein degradation transcription, inhibited 21917920; 28319066 2 0 0 -CEBPB C/EBP-beta DNA-binding; Motility/polarity/chemotaxis; Transcription factor P17676 1051 20q13.13 human S288-p 452156 NNIAVRKsRDKAKMR bZIP_2 intracellular localization 9374525 3 0 0 -NF2 Merlin Cytoskeletal; Motility/polarity/chemotaxis; Tumor suppressor P35240 4771 22q12.2 human S10-p 1720901 GAIASRMsFSSLKRK protein degradation; molecular association, regulation; ubiquitination carcinogenesis, induced; cell motility, altered; cytoskeletal reorganization VPRBP(DISRUPTS) 18071304; 21750658 5 10 0 -POU5F1 Oct4 DNA-binding; Transcription factor Q01860 5460 6p21.33 human K151-ac 57951803 KELEQFAkLLKQKRI Pou molecular association, regulation transcription, induced SOX2(INDUCES) 27369080 1 1 0 -JAK2 JAK2 EC 2.7.10.2; KINASE; Kinase, protein; Oncoprotein; Protein kinase, TK; Protein kinase, tyrosine (non-receptor) O60674 3717 9p24.1 human Y1007-p 448407 VLPQDKEyYKVKEPG PK_Tyr_Ser-Thr activity, induced; molecular association, regulation carcinogenesis, induced; cell motility, induced; cell growth, induced; cell adhesion, induced; apoptosis, inhibited; transcription, induced; signaling pathway regulation SOCS1(INDUCES) 16914724; 22177802; 22508938; 34118143; 34162728; 34380633; 34642304; 34900727; 35296317; 36516775 80 5 15 -Gria1 GluR1 Channel, calcium; Channel, ligand-gated; Membrane protein, integral; Membrane protein, multi-pass P23818 14799 11 B1.3|11 34.51 cM mouse T856-p 3362101 SINEAIRtSTLPRNS activity, induced 17689977 1 0 0 synaptic plasticity -LTF LTF EC 3.4.21.-; Protease; Secreted; Secreted, signal peptide P02788 4057 3p21.31 human K423-ub 41400405 GYVYTAGkCGLVPVL Transferrin ubiquitination 20404350 2 0 0 polyubiquitin acceptor site -PARP1 PARP1 DNA repair, damage; EC 2.4.2.30; Nuclear envelope; Nuclear receptor co-regulator; Nucleolus; Transferase P09874 142 1q42.12 human K203-sm 11539306 KKQLPGVkSEGKRKG protein degradation; molecular association, regulation; ubiquitination transcription, induced RNF4(INDUCES) 19779455 1 4 0 -HSF4 HSF4 Cell development/differentiation; DNA-binding; Transcription, coactivator/corepressor Q9ULV5 3299 16q22.1 human K293-sm 4037601 EKGLALLkEEPASPG sumoylation transcription, inhibited 16371476 1 0 0 SUMO-2 modification was induced by heat stress; sumoylation is depenedent on S298 phosphorylation -ABI1 Abi-1 Adaptor/scaffold; Motility/polarity/chemotaxis Q8IZP0 10006 10p12.1 human S216-p 3205884 VPNDYMTsPARLGSQ molecular association, regulation; intracellular localization; phosphorylation cell cycle regulation; cell growth, induced; cell motility, altered; cytoskeletal reorganization; signaling pathway regulation 21419341; 21900237 3 12 32 regulates WRC (WAVE2 regulatory complex) interaction with Arp2/3 and lamellipodial protrusion; inhibits tyrosine phosphorylation of itself and of WAVE2 by BCR-ABL, inhibits Abi1/WAVE2 signaling -GHR GH receptor Membrane protein, integral; Receptor, cytokine NP_999419 397488 pig Y534-p 486256 NFIMDNAyFCEADAK GHBP transcription, induced DNA(INDUCES) 8647880 3 0 0 -Tnnt2 TNNT2 Motility/polarity/chemotaxis; Motor P50753 24837 13q13 rat T205-p 449038 GYIQKAQtERKSGKR Troponin receptor desensitization, induced 26375298 6 0 0 -DCC DCC Immunoglobulin superfamily; Membrane protein, integral; Receptor, misc.; Tumor suppressor P43146 1630 18q21.2 human Y1420-p 454409 TEDSANVyEQDDLSE Neogenin_C molecular association, regulation RASA1(INDUCES); Lck(INDUCES); Fyn(INDUCES) 18253061; 26710849 5 0 0 -DLC1 DLC1 GAP; GAP, Rac/Rho; Tumor suppressor Q96QB1 10395 8p22 human S868-p 15500000 KELKRRNsSSSMSSR molecular association, regulation 14-3-3 theta(INDUCES) 32606003 2 5 2 -SORBS2 ArgBP2 iso2 Adaptor/scaffold; Motility/polarity/chemotaxis O94875-2 8470 4q35.1 human Y164-p 23083166 PDDDTDMyNTPYTYN protein conformation 24475245 1 0 4 reduced self-interaction -CERT1 COL4A3BP EC 2.7.11.9; KINASE; Kinase, protein; Lipid-binding; Protein kinase, Ser/Thr (non-receptor); Protein kinase, atypical Q9Y5P4 10087 5q13.3 human S147-p 125104504 ASGYSATsTSSFKKG molecular association, regulation; activity, inhibited 28652409 0 1 0 reduced PtdIns(4)P binding affinity as well as low ceramide transfer activity, E494R/N495K/P535R/E537K mutations, recovery of both PtdIns(4)P binding and ceramide transfer activity. -TUBA1A TUBA1A Cytoskeletal; Motility/polarity/chemotaxis Q71U36 7846 12q13.12 human K40-m3 62480700 DGQMPSDkTIGGGDD Tubulin cell cycle regulation; cell motility, induced; cytoskeletal reorganization 27594515; 34226540 3 1 0 crosstalk between TUBA1A K40me3 and a-TUBA1A K40ac ; promotes microtubule formation in neurons; TUBA1A K40me3 promotes tubulin nucleation and microtubule polymerization; neuronal migration in cerebral cortex during E14-E16 -CARD11 CARD11 Adaptor/scaffold Q9BXL7 84433 7p22.2 human S644-p 457638 NLMFRKFsLERPFRP activity, induced; molecular association, regulation transcription, induced AIP(INDUCES); Bcl-10(INDUCES) 24548923; 25245034 5 4 3 NF-kB activation, IL-2 production -CHD4 CHD-4 DNA-binding; EC 3.6.4.12; Helicase Q14839 1108 12p13.31 human S310-p 471449 SKRKRSSsEDDDLDV molecular association, regulation chromatin organization, altered; transcription, induced DNA(DISRUPTS); RNA(DISRUPTS) 29907651 1 14 5 -Ndel1 NDEL1 Microtubule-binding; Protease Q9ERR1 83431 11|11 B3 mouse S332-p 1869686802 PPPGLGSsRPSSAPG cell growth, induced; cell differentiation, induced; cytoskeletal reorganization 31815665 1 1 0 neuronal dendrite outgrowth and arborization -NR1H2 LXR-beta Nuclear receptor P55055 7376 19q13.33 human K447-sm 12004409 ALRLQDKkLPPLLSE molecular association, regulation transcription, inhibited coronin 2A(INDUCES) DNA(INDUCES) 17218271; 21331046 2 0 0 -H2AZ2 H2AFV Q71UI9 94239 7p13 human K13-ac 482540 GKDSGKAkAKAVSRS Histone molecular association, regulation transcription, induced FALZ(INDUCES) 32356653 1 2 95 K7ac preferentially engaging the binding site, acetylation at K7ac and K13ac is also the highest-affinity acetylation pattern of isoform I -RB1 Rb Nuclear receptor co-regulator; Oncoprotein; Transcription, coactivator/corepressor; Tumor suppressor P06400 5925 13q14.2 human T373-p 447982 VNVIPPHtPVRTVMN RB_A molecular association, regulation E2F1(DISRUPTS) 20223825 10 51 40 -PTGS2 COX-2 EC 1.14.99.1; Lipid Metabolism - arachidonic acid; Oxidoreductase P35354 5743 1q31.1 human Y446-p 484179 DQSRQMKyQSFNEYR An_peroxidase enzymatic activity, induced 24970799 1 1 0 -PGK1 PGK1 Carbohydrate Metabolism - glycolysis and gluconeogenesis; EC 2.7.2.3; KINASE; Kinase, other P00558 5230 Xq21.1 human K220-ac 14319999 GGAKVADkIQLINNM PGK enzymatic activity, inhibited 26356530 2 4 0 -GAPDH GAPDH Carbohydrate Metabolism - glycolysis and gluconeogenesis; EC 1.2.1.12; Oxidoreductase P04406 2597 12p13.31 human T246-p 23109023 NVSVVDLtCRLEKPA Gp_dh_C protein conformation signaling pathway regulation 23653351; 27129213 3 3 5 decreased GAPDH tetramerization; GAPDH/PKCD signaling to inhibit I/R-induced mitophagy -KHDRBS1 KHDRBS1 RNA-binding Q07666 10657 1p35.2 human R52-m2 476769 RGGGGGSrGGARASP intracellular localization 12529443 1 3 0 -CHAT CHAT iso3 ACETYLTRANSFERASE; Acetyltransferase; EC 2.3.1.6; Lipid Metabolism - glycerophospholipid P28329-3 1103 10q11.23 human T456-p 449058 VDNIRSAtPEALAFV Carn_acyltransf molecular association, regulation VCP(INDUCES) 12486117 1 1 0 -Runx1 AML1 DNA-binding; Oncoprotein; Transcription factor Q03347 12394 16 C4|16 53.7 cM mouse Y375-p 51211400 FQTGSPSyHLYYGAS RunxI activity, induced; protein stabilization transcription, induced HDAC1(DISRUPTS) DNA(INDUCES) 26598521 1 0 0 -RASSF1 RASSF1 iso2 Tumor suppressor Q9NS23-2 11186 3p21.31 human S197-p 18748000 RGPGRGTsVRRRTSF cytoskeletal reorganization 18514071 2 0 0 -Pla2g4a PLA2G4A EC 3.1.1.4; EC 3.1.1.5; Lipid Metabolism - alpha-linolenic acid; Lipid Metabolism - arachidonic acid; Lipid Metabolism - ether lipid; Lipid Metabolism - glycerophospholipid; Lipid Metabolism - linoleic acid; Phospholipase P47713 18783 1 G1|1 63.51 cM mouse S726-p 447599 RQNPSRCsVSLSNVE enzymatic activity, induced 10978317 8 33 0 -GYS1 GYS1 Carbohydrate Metabolism - starch and sucrose; EC 2.4.1.11; Transferase P13834 100008660 rabbit S641-p 448237 YRYPRPAsVPPSPSL Glycogen_syn enzymatic activity, inhibited 10909964; 16275910; 6402364; 7759494; 7929255; 8226927; 8546708 38 28 2 -LAT LAT Adaptor/scaffold; Membrane protein, integral O43561 27040 16p11.2 human Y255-p 448006 EEEGAPDyENLQELN LAT activity, induced; molecular association, regulation transcription, altered GRB2(INDUCES); PLCG1(INDUCES) 10811803 17 3 72 NF-AT mediated transcription -IL2RB IL2RB Membrane protein, integral; Receptor, cytokine P14784 3560 22q12.3 human T476-p 41591300 PQPLGPPtPGVPDLV transcription, induced 26152718 1 1 0 STAT5B transcriptional activity -Mapt Tau ACETYLTRANSFERASE; Acetyltransferase; Cytoskeletal P10637 17762 11 67.79 cM|11 E1 mouse T504-p 447934 TPGSRSRtPSLPTPP neural plasticity 33428131 52 16 5 -VIPR1 VIPR1 GPCR, family 2; Membrane protein, integral; Membrane protein, multi-pass; Motility/polarity/chemotaxis; Receptor, GPCR P32241 7433 3p22.1 human S250-p 455875 LLAVSFFsERKYFWG 7tm_2 receptor internalization, altered 15932876 2 0 0 -HMGB2 HMGB2 DNA-binding; Nuclear receptor co-regulator P26583 3148 4q34.1 human K3-ac 460591 _____MGkGDPNKPR chromatin organization, altered 15005629 1 1 0 -Clip1 Restin Cytoskeletal Q9JK25 65201 12q16 rat T286-p 483203 KIGFPSTtPAKAKAA intracellular localization cell cycle regulation 19687009 3 6 3 essential for G2/M transition and cell cycle progression -VCL Vinculin Cell adhesion; Cytoskeletal; Motility/polarity/chemotaxis P12003 396422 chicken Y1134-p 454003 WVRKTPWyQ______ activity, induced; molecular association, regulation; intracellular localization; protein conformation cell adhesion, altered VASP(INDUCES) 15229287; 19422016; 21071443; 25759389 9 1 22 phosphorylation of this site positively regulates cell spreading; plays an important role in vinculin exchange dynamics -MYBL2 B-Myb DNA-binding; Motility/polarity/chemotaxis; Transcription factor P10244 4605 20q13.12 human T520-p 450112 DNTPHTPtPFKNALE Cmyb_C molecular association, regulation; protein conformation transcription, induced DNA(INDUCES) 35926712 3 1 9 -CDK4 CDK4 Cell cycle regulation; EC 2.7.11.22; KINASE; Kinase, protein; Protein kinase, CMGC; Protein kinase, Ser/Thr (non-receptor) P11802 1019 12q14.1 human T172-p 448476 YSYQMALtPVVVTLW Pkinase enzymatic activity, induced cell cycle regulation; carcinogenesis, induced; cell growth, induced 16782892; 19237555; 20484410; 23737759; 36446794; 36453028 12 4 3 -LIME1 LIME1 Adaptor/scaffold; Membrane protein, integral Q9H400 54923 20q13.33 human Y254-p 463811 SGPLENVyESIRELG LIME1 molecular association, regulation Lck(INDUCES); Fyn(INDUCES) 14610046 3 3 13 -M Membrane Protein P0DTC5 43740571 SARSCoV2 K15-ub 1881871200 ITVEELKkLLEQWNL molecular association, regulation exocytosis, induced Envelope Protein(INDUCES) 35100873 1 0 0 enhancing the interaction of viral envelope with membrane, virus-like particle (VLP) release -CHRNA7 nAChRA7 Channel, cation; Channel, ligand-gated; Membrane protein, integral; Membrane protein, multi-pass P36544 1139 15q13.3 human Y386-p 457466 ASNGNLLyIGFRGLD Neur_chan_memb activity, inhibited 16251431 1 0 0 -TTK TTK Cancer Testis Antigen (CTA); EC 2.7.12.1; KINASE; Kinase, protein; Protein kinase, Other; Protein kinase, dual-specificity (non-receptor) P33981 7272 6q14.1 human T806-p 4145514 NQMAKGTtEEMKYVL enzymatic activity, inhibited 18680479 1 0 0 in vitro -HSPA1A HSP70 Chaperone; Heat shock protein; Motility/polarity/chemotaxis P0DMV8 3303 6p21.33 human S631-p 483567 AQGPKGGsGSGPTIE activity, induced; protein stabilization; intracellular localization apoptosis, induced CHIP(DISRUPTS) 24623308; 30485823 2 13 0 spindle elongation; Promotes deubiquitination and stabilization of HSP70 along with SOD2 import and stabilization, regulates mitochondrial redox balance -EDNRA EDNRA GPCR, family 1; Membrane protein, integral; Membrane protein, multi-pass; Motility/polarity/chemotaxis; Receptor, GPCR P25101 1909 4q31.22-q31.23 human T396-p 2911714 YQSKSLMtSVPMNGT receptor desensitization, induced 24064210 1 1 0 Lack of S397, T403 and S404 influences desensitization to a greater extent compared than S391, S393, and T396 -GATA1 GATA1 DNA-binding; Transcription factor P15976 2623 Xp11.23 human K315-ac 466358 KASGKGKkKRGSSLG molecular association, regulation transcription, altered DNA(INDUCES) 16888089 1 0 0 -Elk1 ELK1 DNA-binding; Transcription factor A4GTP4 314436 Xq11 rat K229-sm 3982502 PPEAPNQkSEELSLN apoptosis, inhibited; transcription, inhibited 30849179 6 2 0 GADD45A expression; APP/PS1 rats -CD5 CD5 Cell surface; Membrane protein, integral P06127 921 11q12.2 human T434-p 450129 MSFHRNHtATVRSHA activity, induced; receptor internalization, altered 11123317 1 0 44 -Glra3 GLRA3 Membrane protein, integral; Membrane protein, multi-pass; Transporter; Transporter, ion channel P24524 rat S379-p 1848000 TDDEVREsRLSFTAY Neur_chan_memb protein conformation 23834509 2 0 0 -Nr4a3 NR4A3 DNA-binding; Nuclear receptor; Oncoprotein Q9QZB6 18124 4|4 B1 mouse S139-p 1874485100 TSMYFKQsPPSTPTT sumoylation; protein stabilization; activity, inhibited cell growth, inhibited; apoptosis, induced; transcription, altered 34383980 1 0 0 induces sumoylation at K137 -Noxa1 NOXA1 Activator Q8CJ00 241275 2|2 A3 mouse Y252-p 1869151102 GHTSPGLyDSLLASR activity, inhibited 20230789 1 0 0 inhibits Nox1 activity -Myc Myc DNA-binding; Nucleolus; Oncoprotein; Transcription factor P01108 17869 15 D1|15 26.19 cM mouse T373-p 450960 EENDKRRtHNVLERQ HLH activity, inhibited cell cycle regulation; apoptosis, inhibited; transcription, altered; transcription, inhibited; cell growth, altered 14749374; 20043278 6 0 0 mutation of this site enhances epidermal differentiation -Smyd2 SMYD2 EC 2.1.1.43; METHYLTRANSFERASE; Methyltransferase; Methyltransferase, protein lysine Q8R5A0 226830 1|1 H6 mouse Y240-p 4144300 GDEVFTSyIDLLYPT SET methylation; enzymatic activity, induced 16805913 1 0 0 induces histone methylation -NTRK1 TrkA EC 2.7.10.1; KINASE; Kinase, protein; Membrane protein, integral; Oncoprotein; Protein kinase, TK; Protein kinase, tyrosine (receptor) P04629 4914 1q23.1 human Y681-p 447764 DIYSTDYyRVGGRTM PK_Tyr_Ser-Thr receptor internalization, altered; enzymatic activity, induced 15601748 14 3 6 -Pdcd4 PDCD4 Apoptosis; Tumor suppressor Q61823 18569 19 D2|19 48.73 cM mouse S457-p 458382 RGRKRFVsEGDGGRL translation, inhibited 28644433 8 74 46 -NR3C1 GR DNA-binding; Mitochondrial; Nuclear receptor; Transcription factor P04150 2908 5q31.3 human S617-p 1872513503 WRSYRQSsANLLCFA Hormone_recep molecular association, regulation 14-3-3 zeta(INDUCES) 33744286 1 1 0 -Kras KRas iso2 G protein; G protein, monomeric; G protein, monomeric, Ras; Motility/polarity/chemotaxis; Oncoprotein P32883-2 16653 6 G3|6 77.37 cM mouse S181-p 459210 GKKKKKKsRTRCTVM molecular association, regulation transcription, induced Calmodulin(DISRUPTS) 26590425 10 0 0 increase in Fzd8 promoter activity, and of NF-AT transcription -CHAT CHAT iso3 ACETYLTRANSFERASE; Acetyltransferase; EC 2.3.1.6; Lipid Metabolism - glycerophospholipid P28329-3 1103 10q11.23 human S476-p 454037 HKAAVPAsEKLLLLK Carn_acyltransf enzymatic activity, induced 15381704 1 0 0 -HCRTR1 HCRTR1 GPCR, family 1; Membrane protein, integral; Membrane protein, multi-pass; Receptor, GPCR O43613 3061 1p35.2 human S262-p 1869999600 VRNWKRPsDQLGDLE 7tm_1 receptor internalization, induced; molecular association, regulation endocytosis, induced GRK2(INDUCES); AP-2 alpha(INDUCES) 32827691 1 1 0 -CHEK2 Chk2 EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, CAMK; Protein kinase, Ser/Thr (non-receptor); Tumor suppressor O96017 11200 22q12.1 human S164-p 12473002 IAYIEDHsGNGTFVN FHA enzymatic activity, inhibited cell cycle regulation 20126263 1 1 0 mutation of this site impairs checkpoint recovery -YAP1 YAP1 Oncoprotein; Transcription, coactivator/corepressor P46937 10413 11q22.1 human T110-p 452306 SHSRQAStDAGTAGA protein degradation 25660024 3 22 274 -APPL1 APPL Adaptor/scaffold; Nuclear receptor co-regulator Q9UKG1 26060 3p14.3 human K160-ub 40212807 KRENDKVkYEVTEDV BAR_3 intracellular localization 23909487 1 2 0 Akt activation and gluconeogenesis -Ppm1h PPM1H EC 3.1.3.16; PHOSPHATASE; Phosphatase Q3UYC0 319468 10|10 D2 mouse S123-p 479930 RNSKRRSsLPNGEGL phosphorylation; enzymatic activity, induced 32600616 1 30 14 phosphorylation at S210; dephosphorylation of SMAD1 -Gata4 GATA4 Motility/polarity/chemotaxis; Transcription factor P46152 54254 15p12 rat S105-p 449604 AYTPPPVsPRFSFPG GATA-N activity, induced; molecular association, regulation; intracellular localization; phosphorylation cell growth, induced; apoptosis, inhibited; transcription, induced; signaling pathway regulation; transcription, altered DNA(INDUCES) 11585926; 12468531; 17227882; 19546173; 21702924; 22227582; 22228770; 22473995; 32060996; 36279967 16 0 0 -KCNMA1 KCNMA1 Channel, potassium; Endoplasmic reticulum; Membrane protein, integral; Membrane protein, multi-pass Q8AYS8 374065 chicken T871-p 4715376 QANSQGFtPPGMDRS intracellular localization; activity, inhibited 22094329 1 2 0 -TP53 p53 Activator; DNA-binding; Motility/polarity/chemotaxis; Nuclear receptor co-regulator; Transcription factor; Tumor suppressor P04637 7157 17p13.1 human K24-ub 60176101 ETFSDLWkLLPENNV P53_TAD intracellular localization cell growth, inhibited; apoptosis, inhibited BAK1(INDUCES); MCL1(DISRUPTS) 27818144 1 0 0 inhibits p53 mitochondrial localization -BIK BIK Apoptosis; Membrane protein, integral; Mitochondrial Q13323 638 22q13.2 human S124-p 32001602 NIMRFWRsPNPGSWV bcl-2I13 protein degradation; ubiquitination carcinogenesis, induced; apoptosis, inhibited 24637719 1 0 0 BIK phosphodeficient mutant enhanced anti-tumor effects of 5-FU -SUN1 SUN1 iso9 Cytoskeletal; Membrane protein, integral O94901-9 23353 7p22.3 human S48-p 7101126 KLDPVFDsPRMSRRS intracellular localization 25482198 1 13 0 accumulation in the ER -DMTN dematin iso2 Actin-binding; Motility/polarity/chemotaxis; Tumor suppressor Q08495-2 2039 8p21.3 human S381-p 450255 NELKKKAsLF_____ VHP protein conformation cytoskeletal reorganization 23355471 5 0 0 Phosphorylation of S381 eliminates the F-actin bundling activity, induced a compact quartenary structure, and caused the headpiece to associate with the core domain. -RHO Rhodopsin GPCR, family 1; Membrane protein, integral; Membrane protein, multi-pass; Receptor, GPCR P08100 6010 3q22.1 human S338-p 448679 DEASATVsKTETSQV molecular association, regulation ARRB1(INDUCES) 28753425 8 7 0 -SHC1 SHC1 iso2 Adaptor/scaffold; Apoptosis; Mitochondrial; Motility/polarity/chemotaxis P29353-2 6464 1q21.3 human Y410-p 23144113 STTTPGQyVLTGLQS SH2 molecular association, regulation JAK3(INDUCES) 24795043 1 0 5 -KDM1A LSD1 DEMETHYLASE; Demethylase; EC 1.-.-.-; Nuclear receptor co-regulator; Oxidoreductase; Transcription factor O60341 23028 1p36.12 human S137-p 449181 LSEDEYYsEEERNAK molecular association, regulation; ubiquitination; intracellular localization cell growth, induced RNF168(INDUCES) 25999347 1 46 275 recruited to sites of DNA damage, promotes the interaction between 53BP1 and RNF168 in chromatin, RNF168-dependent 53BP1 ubiquitination -Nr3c1 GR DNA-binding; Mitochondrial; Nuclear receptor; Transcription factor P06536 24413 18p11 rat S155-p 3178932 ANLNRSTsVPENPKS GCR intracellular localization transcription, induced 23878391 12 11 6 -BTLA BTLA Membrane protein, integral Q7Z6A9 151888 3q13.2 human Y282-p 463077 VKEAPTEyASICVRS phosphorylation signaling pathway regulation 32437509 1 0 6 inhibits IL2 production, phosphorylation of CD3Z and CD28, and hence T cell signaling -SMURF1 SMURF1 EC 6.3.2.-; EC 6.3.2.19; Ligase; UBIQUITIN LIGASE; Ubiquitin conjugating system; Ubiquitin ligase Q9HCE7 57154 7q22.1 human K383-ub 1872850900 RDLVQKLkVLRHELS protein degradation 21572392 1 0 0 -POLB POLB DNA repair, damage; DNA replication; EC 2.7.7.7; Lyase; Transferase P06746 5423 8p11.21 human K41-ub 12723501 HKYNAYRkAASVIAK HHH_8 protein degradation DNA repair, inhibited 19713937 1 2 0 -Aqp2 AQP2 Channel, misc.; Membrane protein, integral; Membrane protein, multi-pass; Transporter; Transporter, aquaporin family P56402 11827 15 F1|15 56.13 cM mouse S269-p 3339002 PQSLPRGsKA_____ protein stabilization; molecular association, regulation; intracellular localization endocytosis, induced; endocytosis, altered; endocytosis, inhibited 14-3-3 theta(INDUCES); 14-3-3 zeta(INDUCES); HSP70(DISRUPTS); SIPA1L1(DISRUPTS) 18606813; 19966308; 23935101; 24876223; 26645691; 28336531; 32799672; 36823952 37 5 0 -FGFR2 FGFR2 EC 2.7.10.1; KINASE; Kinase, protein; Membrane protein, integral; Oncoprotein; Protein kinase, TK; Protein kinase, tyrosine (receptor) P21802 2263 10q26.13 human S782-p 2532302 PLEQYSPsYPDTRSS molecular association, regulation cell cycle regulation; cell growth, altered 14-3-3 zeta(INDUCES) 18332103 2 0 0 reguates cell survival in response to FGF2 -Nlgn1 NLGN1 Membrane protein, integral Q99K10 192167 3|3 A3 mouse T739-p 30318201 CSPQRTTtNDLTHAP intracellular localization 24336150 1 1 0 NL-1 mediated synaptogenesis, surface expression -MAPK1 ERK2 EC 2.7.11.24; KINASE; Kinase, protein; Protein kinase, CMGC; Protein kinase, Ser/Thr (non-receptor) P28482 5594 22q11.22 human T190-p 3949250 FLTEYVAtRWYRAPE Pkinase molecular association, regulation; protein conformation; enzymatic activity, induced G-beta 1(INDUCES) 19060905 4 17 17 -Musk MUSK EC 2.7.10.1; KINASE; Kinase, protein; Membrane protein, integral; Protein kinase, TK; Protein kinase, tyrosine (receptor) Q62838 rat Y553-p 2848304 RLHPNPMyQRMPLLL phosphorylation; enzymatic activity, induced 10619845 2 3 0 promotes MuSK phosphorylation; promotes AChRb clustering and phosphorylation -Kif13b KIF13B Microtubule-binding; Motor Q70AM4 305967 15p12 rat T506-p 27145806 PEGQVMLtPQKNTRT FHA molecular association, regulation TRPV1(INDUCES) 23077056 1 0 0 Phosphorylation at T506 is important for TRPV1 membrane trafficking -BARD1 BARD1 EC 6.3.2.-; EC 6.3.2.19; Ligase; UBIQUITIN LIGASE; Ubiquitin conjugating system; Ubiquitin ligase Q99728 580 2q35 human S391-p 455774 SDEFISLsPGTPPST cell cycle regulation 15855157 1 8 0 resistance to genotoxic stress (mitomycin C) -NR1I2 PXR DNA-binding; Nuclear receptor O75469 8856 3q13.33 human T290-p 25682902 LCQLRFNtVFNAETG Hormone_recep molecular association, regulation; intracellular localization transcription, inhibited HSP90A(INDUCES); DNAJC7(INDUCES) 22829544; 25074870 2 0 0 -VHL VHL Tumor suppressor; UBIQUITIN LIGASE; Ubiquitin ligase P40337 7428 3p25.3 human S80-p 50792657 QVIFCNRsPRVVLPV VHL protein degradation; molecular association, regulation; ubiquitination carcinogenesis, induced; cell motility, induced; cell growth, induced PIN1(INDUCES) 36813923 1 2 0 -PIK3R1 PIK3R1 KINASE; Kinase, lipid; Motility/polarity/chemotaxis P27986 5295 5q13.1 human S83-p 471075 YIGRKKIsPPTPKPR protein degradation; molecular association, regulation; intracellular localization; phosphorylation carcinogenesis, induced; cell growth, induced; apoptosis, inhibited; signaling pathway regulation 14-3-3 zeta(INDUCES) 21743495 3 1 1 induces phosphorylation of Akt and degradation of p53, regulates PI3k/Akt pathway -VIL1 Villin Actin-binding; Motility/polarity/chemotaxis P09327 7429 2q35 human T206-p 15428881 DQERGGRtYVGVVDG Gelsolin cytoskeletal reorganization 29074568 1 1 1 membrane fusion; upon membrane fusion with Sendai virosomes -HSP90AA1 HSP90A Chaperone; Heat shock protein P07900 3320 14q32.31 human T603-p 12078914 PCCIVTStYGWTANM HSP90 molecular association, regulation PKCG(DISRUPTS) 24117238 1 0 8 PKC? phosphorylation of chaperone Hsp90? triggers its own release from the Hsp90? chaperone machinery. -Ppp1r14a PPP1R14A Inhibitor; Protein phosphatase, regulatory subunit Q99MC0 114004 1q21 rat T38-p 449098 QKRHARVtVKYDRRE PP1_inhibitor activity, inhibited; phosphorylation 12359219 29 0 0 upregulates the inhibition on PP1delta activity -Znrf1 ZNRF1 EC 6.3.2.-; EC 6.3.2.19; Ligase; UBIQUITIN LIGASE; Ubiquitin conjugating system; Ubiquitin ligase Q91V17 170737 8|8 E1 mouse Y103-p 479016 TYAHGNGyQETGGGH ubiquitination; enzymatic activity, induced apoptosis, induced 26572622 2 2 38 ZNFR1-dependent Akt ubiquitination, Wallerian degeneration -FAM83G FAM83G A6ND36 644815 17p11.2 human S356-p 3147942 YALVKAKsVDEIAKI phosphorylation apoptosis, induced 32570757 1 17 0 decreases HSP27 phosphorylation -UNC119 UNC119 Adaptor/scaffold Q13432 9094 17q11.2 human Y194-p 1869344407 KNTCEHIyDFPPLSE GMP_PDE_delta molecular association, regulation signaling pathway regulation KRas iso2(INDUCES) 32554467 1 0 0 UNC119A-KRAS-RASSF6-MDM2-p53 pathway -Star STAR Carrier; Lipid-binding; Mitochondrial P51557 20845 8 A2|8 14.17 cM mouse S194-p 450442 RCTKRRGsTCVLAGM START activity, induced; molecular association, regulation signaling pathway regulation 14-3-3 gamma(INDUCES) 22427666; 22681886; 24850413 9 1 0 -CDK5R2 CDK5R2 Protein kinase, regulatory subunit Q13319 8941 2q35 human S8-p 15499459 MGTVLSLsPASSAKG intracellular localization 22467861 1 0 1 CDK5R2 S8 in its unphosphorylated form accumulates at the perinuclear region and T84 plays a role in the nuclear localization of CDK5R2. -WRN WRN Cell cycle regulation; DNA repair, damage; DNA-binding; EC 3.6.4.12; Helicase; Nucleolus Q14191 7486 8p12 human S1141-p 481875 PEKAYSSsQPVISAQ protein degradation; molecular association, regulation; ubiquitination cell cycle regulation; DNA repair, induced DNA(INDUCES) 26695548 3 3 0 WRN replication at S1141 modulates its dissociation from DSBs during replication stress and prevents chromosome breaks -Pln PLB Inhibitor; Membrane protein, integral P61016 64672 20q11 rat T17-p 448115 SAIRRAStIEMPQQA Phospholamban activity, induced 12355181; 21447388 75 12 63 induce calcium uptake -ARHGEF7 ARHGEF7 iso1 GEF; GEF, Rac/Rho; Motility/polarity/chemotaxis Q14155-1 8874 13q34 human Y442-p 3753309 PAPLTPAyHTLPHPS molecular association, regulation carcinogenesis, induced; cell motility, induced; cell motility, altered DYN2(INDUCES); GIT1(DISRUPTS) 20375009; 34582006 3 0 4 -Grm8 mGluR8 GPCR, family 3; Membrane protein, integral; Membrane protein, multi-pass; Receptor, GPCR P47743 14823 6|6 A3.1-A3.2 mouse K882-sm 3726908 DRPNGEVkSELCESL signaling pathway regulation 16144832 2 0 0 GPCR signaling -CASP7 CASP7 Apoptosis; EC 3.4.22.60; Endoplasmic reticulum; Mitochondrial; Protease P55210 840 10q25.3 human T173-p 20473606 FRGDRCKtLLEKPKL Peptidase_C14 activity, inhibited apoptosis, inhibited 21555521 2 0 0 caspase7 cleavage supressed -ELAVL1 HuR RNA-binding Q15717 1994 19p13.2 human S100-p 474553 VSYARPSsEVIKDAN protein degradation; molecular association, regulation RNA splicing, induced; translation, induced; RNA stability, altered RNA(INDUCES); RNA(DISRUPTS) 17317627; 21745814; 24865968; 32929216; 36968077 5 1 1 -CSF1R CSFR EC 2.7.10.1; KINASE; Kinase, protein; Membrane protein, integral; Oncoprotein; Protein kinase, TK; Protein kinase, tyrosine (receptor) P07333 1436 5q32 human Y708-p 451528 NIHLEKKyVRRDSGF PK_Tyr_Ser-Thr activity, induced; molecular association, regulation STAT1(INDUCES) 9000134 12 0 0 -PRKDC DNAPK DNA repair, damage; EC 2.7.11.1; KINASE; Kinase, protein; Nucleolus; Protein kinase, Ser/Thr (non-receptor); Protein kinase, atypical P78527 5591 8q11.21 human T4102-p 1881979000 ESGLSEEtQVKCLMD molecular association, regulation; phosphorylation; enzymatic activity, induced DNA repair, induced Ku80(INDUCES); Ku70(INDUCES) DNA(DISRUPTS) 37309889 1 0 0 induces H2AX and TIF1B phosphorylation -ATAT1 ATAT1 ACETYLTRANSFERASE; Acetyltransferase; EC 2.3.1.108 Q5SQI0 79969 6p21.33 human S315-p 4761832 LAADPGGsPAQRRRT molecular association, regulation; intracellular localization 14-3-3 beta(INDUCES); 14-3-3 zeta(INDUCES); 14-3-3 epsilon(INDUCES); 14-3-3 gamma(INDUCES) 36222836 1 21 10 -Prkaa2 AMPKA2 Autophagy; EC 2.7.11.1; EC 2.7.11.27; EC 2.7.11.31; KINASE; Kinase, protein; Protein kinase, CAMK; Protein kinase, Ser/Thr (non-receptor) Q09137 78975 5q34 rat T172-p 448026 SDGEFLRtSCGSPNY Pkinase enzymatic activity, induced 10642499; 12015362; 17253964; 33848515 220 13 33 -LMNA lamin A/C Cytoskeletal P02545 4000 1q22 human S657-p 4661905 NSSPRTQsPQNCSIM activity, induced; intracellular localization 18815303 1 2 0 nuclear lamin disassemby -MAVS MAVS Adaptor/scaffold; Membrane protein, integral Q7Z434 57506 20p13 human S329-gl 1872691005 VPSKLPTsSKPPGAV phosphorylation 31461653 1 1 0 positively regulates phosphorylation of S442 (data from MAVS 7A mutant) -PDGFRB PDGFRB EC 2.7.10.1; KINASE; Kinase, protein; Membrane protein, integral; Oncoprotein; Protein kinase, TK; Protein kinase, tyrosine (receptor) P09619 5159 5q32 human Y934-p 447518 AHASDEIyEIMQKCW PK_Tyr_Ser-Thr enzymatic activity, induced cell motility, altered 19275932 1 2 1 in vitro -TRAF6 TRAF6 EC 6.3.2.-; Ligase; UBIQUITIN LIGASE; Ubiquitin conjugating system; Ubiquitin ligase Q9Y4K3 7189 11p12 human K124-ub 486279 LFPDNFAkREILSLM protein degradation; molecular association, regulation; ubiquitination; phosphorylation cell differentiation, induced; transcription, induced; signaling pathway regulation UBL4A(INDUCES) 17135271; 19825828; 31451677 3 1 0 UBL4A promotes K63-linked ubiquitination of TRAF6; induces IKB phosphorylation and degradation, thus inducing NF-kB signaling; activation of NFkB and IKK, signaling in osteoclast differentiation, induces NEMO ubiquitination -IRF3 IRF3 DNA-binding; Transcription factor Q14653 3661 19q13.33 human S188-p 30312501 PFPNLGPsENPLKRL molecular association, regulation transcription, inhibited IRF7(INDUCES) 24275658 1 0 0 Formation of IRF3:IRF7 dimers -STAT2 STAT2 DNA-binding; Transcription factor P52630 6773 12q13.3 human S287-p 27259020 KGLSCLVsYQDDPLT STAT_alpha molecular association, regulation; intracellular localization cell growth, inhibited; transcription, inhibited DNA(DISRUPTS) 23139419 1 1 0 phosphorylation limits nuclear translocalization -SP7 osterix C2H2-type zinc finger protein; DNA-binding; Transcription factor Q8TDD2 121340 12q13.13 human K230-ub 31914105 VLPQDVYkPKAVGNS protein degradation cell differentiation, inhibited; transcription, inhibited 23457570 1 0 0 -Ackr3 CMKOR1 GPCR, family 1; Membrane protein, integral; Membrane protein, multi-pass; Receptor, GPCR P56485 12778 1 D|1 45.28 cM mouse S350-p 4709309 LIDASRVsETEYSAL protein degradation endocytosis, induced 30726732 1 9 0 promotes endocytosis and scavenging of CXCL12 and induced degradation of CXCR4 -AXIN1 axin 1 iso2 Adaptor/scaffold; Tumor suppressor O15169-2 8312 16p13.3 human K821-ub 40212802 FEEKIIGkVEKVD__ DIX molecular association, regulation signaling pathway regulation LRP5(DISRUPTS); LRP6(DISRUPTS) 23959799 1 0 0 regulates Wnt/beta-catenin signaling, inhibits LRP6 phosphorylation -HSF1 HSF1 DNA-binding; Transcription factor Q00613 3297 8q24.3 human K118-ac 31953303 LLENIKRkVTSVSTL HSF_DNA-bind activity, inhibited transcription, inhibited 24581496 1 1 0 -NFAT5 NFAT5 Transcription factor O94916 10725 16q22.1 human Y143-p 12127405 PKRHTVLyISPPPED activity, induced; molecular association, regulation; intracellular localization transcription, induced; transcription, altered PLCG1(INDUCES) 20080774; 20351292; 20585028; 30190682 5 1 0 -OTUB1 OTUB1 DEUBIQUITINASE; EC 3.4.19.12; Protease; Ubiquitin conjugating system; Ubiquitin-specific protease Q96FW1 55611 11q13.1 human K71-ub 4954019 DDNIYQQkIKDLHKK Peptidase_C65 enzymatic activity, induced 32842143 1 9 41 K71R mutant failed to deubiquitinate MAF -PPARG PPAR-gamma DNA-binding; Nuclear receptor; Transcription factor P37231 5468 3p25.2 human K382-ac 1881289200 FMTREFLkSLRKPFG transcription, altered 33955199 1 0 0 affects lipid accumulation in adipocytes, PPAR-gamma K382Q mutant overexpression led to the reduced expression of several PPAR-gamma target genes -MYH10 MYH10 Motility/polarity/chemotaxis; Motor P35580 4628 17p13.1 human S1939-p 3189934 GPISFSSsRSGRRQL cytoskeletal reorganization 25869664 1 18 2 poorly defined actomyosin bundles distributed throughout the cell -EZH2 EZH2 EC 2.1.1.43; METHYLTRANSFERASE; Methyltransferase; Methyltransferase, protein lysine Q15910 2146 7q36.1 human T416-p 10417699 EANSRCQtPIKMKPN molecular association, regulation; phosphorylation carcinogenesis, induced; cell motility, induced; cell growth, induced; transcription, induced; transcription, inhibited NIPP-1(INDUCES) 23241245; 26279746; 32368395 5 7 7 inhibition of EZH2 activity(dephosphorylation) causes CDK2 phosphorylation -SLC9A1 NHE1 Membrane protein, integral; Membrane protein, multi-pass; Motility/polarity/chemotaxis; Transporter; Transporter, SLC family P19634 6548 1p36.11 human S766-p 18262072 DGGIMMRsKETSSPG activity, induced 23678047 2 2 0 -CLIC1 CLIC1 Channel, chloride; Membrane protein, integral; Nuclear envelope O00299 1192 6p21.33 human K131-ac 466245 ALNDNLEkGLLKALK GST_C_2 protein stabilization; ubiquitination carcinogenesis, induced; cell motility, induced; cell growth, induced 33469837 1 5 3 stabilizes CLIC1, inhibits ubiquitylation and degradation, K131R overexpression induces cancer cell proliferation, migration and invasion, and in vivo tumorigenesis -Fus hnRNP P2 DNA-binding; Nuclear receptor co-regulator; Oncoprotein; RNA splicing; RNA-binding; SUMO LIGASE P56959 233908 7|7 F3 mouse Y297-p 1869633700 TIESVADyFKQIGII RRM_1 intracellular localization 32678881 1 0 0 Induce fibrotic signaling -PHF2 PHF2 DEMETHYLASE; Demethylase; EC 1.14.11.-; Nucleolus O75151 5253 9q22.31 human S954-p 20936501 QKSKKKKsAKRKLTP molecular association, regulation transcription, induced Mrf-2(INDUCES) DNA(INDUCES) 21532585 1 0 0 demethylation of Mrf-2 K336, complex is then targeted to promoters and removes repressive H3K9m2 -Yy1 YY1 C2H2-type zinc finger protein; Cell development/differentiation; Transcription factor Q00899 22632 12 F1|12 59.58 cM mouse K393-ac 1881842001 PFDGCNKkFAQSTNL molecular association, regulation transcription, induced DNA(DISRUPTS) 35024765 1 1 0 -Insr INSR EC 2.7.10.1; KINASE; Kinase, protein; Membrane protein, integral; Protein kinase, TK; Protein kinase, tyrosine (receptor) P15208 16337 8 A1.1|8 1.82 cM mouse T1177-p 14574883 MTRDIYEtDYYRKGG PK_Tyr_Ser-Thr enzymatic activity, inhibited; phosphorylation signaling pathway regulation 33411692 1 4 52 inhibits PDE3B activity, induces PKA activity, induces phosphorylation of perilipin, HSL, and ATGL, leads to insulin resistance -NOXA1 NOXA1 Activator Q86UR1 10811 9q34.3 human S282-p 12570900 VGKQAPLsPGLPAMG molecular association, regulation RAC1(DISRUPTS); NOX1(DISRUPTS) 20110267 1 0 0 prevents hyperactivation of NOX1 -Kcnk10 TREK-2 Channel, potassium; Membrane protein, integral; Membrane protein, multi-pass Q9JIS4 65272 6q32 rat S326-p 465529 GDWLRVLsKKTKEEV activity, inhibited 16672694; 17540699 2 0 0 relative channel activity reduced in S326D and S359D mutants; shift of gating modes; inhibition mediated by ACh -UPF1 RENT1 C2H2-type zinc finger protein; EC 3.6.1.-; EC 3.6.4.-; Hydrolase; RNA-binding Q92900 5976 19p13.11 human S1107-p 456314 SQIDVALsQDSTYQG molecular association, regulation RNA stability, inhibited SMG7(INDUCES); SMG5(INDUCES) 21965535; 23826386 5 51 45 regulates nonsense-mediated RNA decay, phosphorylation blocked by MARVELD1; important for NMD (nonsense-mediated mRNA decay); as apart of SMD-5:SMG-7 complex binding -Golga3 GOLGA3 Vesicle P55937 269682 5 F|5 53.36 cM mouse S385-p 478659 EVRSRRDsICSSVSM apoptosis, altered 17888676 1 8 28 protected against Brefeldin-A-induced apoptosis, but not Fas-mediated apoptosis. -Gria2 GluR2 Channel, calcium; Channel, ligand-gated; Membrane protein, integral; Membrane protein, multi-pass P19491 29627 2q33 rat Y876-p 452173 YKEGYNVyGIESVKI receptor internalization, induced; molecular association, regulation; receptor internalization, altered neural plasticity IQSEC1(INDUCES) 14976558; 15240807; 20547133; 33798429 9 5 109 -HSP90AA1 HSP90A Chaperone; Heat shock protein P07900 3320 14q32.31 human K407-ac 11315724 REMLQQSkILKVIRK HSP90 molecular association, regulation apoptosis, induced TSC1(INDUCES) 31645902 1 5 0 -Rasgrf1 RASGRF1 GEF; GEF, Ras P28818 192213 8q31 rat S611-p 18710207 QMIKSDAsLYCDDVD protein degradation 21382555 1 1 0 -SPP1 osteopontin Secreted; Secreted, signal peptide P10451 6696 4q22.1 human S120-p 455737 DTDDSHQsDESHHSD Osteopontin molecular association, regulation; activity, inhibited Other(INDUCES) 19775205 1 5 0 peptide with phosphorylated S117, S120, S123, S126 and S129 has increased binding to hydroxyapatite, and inhibits bone mineralization in vivo and in vitro -TRIM24 TRIM24 EC 2.3.2.27; KINASE; Kinase, protein; Nuclear receptor co-regulator; Protein kinase, atypical; Transcription, coactivator/corepressor; Tumor suppressor; UBIQUITIN LIGASE; Ubiquitin conjugating system; Ubiquitin ligase O15164 8805 7q33-q34 human S768-p 481699 TSLLLNSsQSSTSEE protein degradation; molecular association, regulation; phosphorylation DNA repair, induced MRE11A(INDUCES); p53(DISRUPTS) DNA(INDUCES) 24820418; 36550358 2 4 2 induces H2AX phosphorylation -HINT1 HINT1 Cytoskeletal; EC 3.-.-.-; Hydrolase P49773 3094 5q23.3 human K30-ac 11320683 IRKEIPAkIIFEDDR HIT molecular association, regulation carcinogenesis, induced; cell growth, induced CTNNB1(DISRUPTS); MITF(INDUCES) 32636443 1 7 0 -ATXN10 ataxin-10 Cell development/differentiation Q9UBB4 25814 22q13.31 human S77-p 21514207 QVENLASsLQLITEC protein degradation; ubiquitination cell cycle regulation 21857149 2 1 0 required for cytokinesis -Appl1 APPL Adaptor/scaffold; Nuclear receptor co-regulator ENSRNOP00000018413 rat S705-p 56689902 EEGKKREsEA_____ activity, induced; molecular association, regulation PSD-95(INDUCES) 27300007 1 0 0 synaptic activity -RANGAP1 RANGAP1 GAP; GAP, Ras P46060 5905 22q13.2 human S358-p 458865 AKVLASLsDDEDEEE molecular association, regulation RAN(INDUCES); RANBP1(INDUCES) 16428860 1 3 0 -TBK1 TBK1 EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, Other; Protein kinase, Ser/Thr (non-receptor) Q9UHD2 29110 12q14.2 human R228-me 1881361503 FRPFEGPrRNKEVMY enzymatic activity, induced 34551290 1 0 0 TBK1 aggregation, PRMT1 positively regulates antiviral immune responses, and promotes cellular innate antiviral signaling -Nr4a1 Nur77 Apoptosis; DNA-binding; Nuclear receptor P12813 15370 15|15 F1 mouse S344-p 451513 KEVVRTDsLKGRRGR transcription, altered; signaling pathway regulation 35363898 2 2 0 regulates the Nur77? FGF21 pathway -BRAF BRAF EC 2.7.11.1; KINASE; Kinase, protein; Oncoprotein; Protein kinase, Ser/Thr (non-receptor); Protein kinase, TKL Q04982 396239 chicken S486-p 447804 KTLGRRDsSDDWEIP enzymatic activity, induced 16702958 15 44 87 important for cell differentiation -FOXA2 FOXA2 DNA-binding; Transcription factor Q9Y261 3170 20p11.21 human T156-p 4911901 KTYRRSYtHAKPPYS Forkhead_N intracellular localization transcription, altered 14500912 2 0 0 -PPME1 PPME1 DEMETHYLASE; EC 3.1.1.89; Hydrolase; Motility/polarity/chemotaxis; Protein phosphatase, regulatory subunit Q9Y570 51400 11q13.4 human S15-p 476688 MHLGRLPsRPPLPGS enzymatic activity, induced 24841198 2 10 8 -VDAC1 VDAC1 Channel, misc.; Membrane protein, integral; Mitochondrial P21796 7416 5q31.1 human S13-p 479874 TYADLGKsARDVFTK Porin_3 protein stabilization apoptosis, induced 18381814; 25296756 2 3 0 -GTF2B GTF2B ACETYLTRANSFERASE; Acetyltransferase; Nuclear receptor co-regulator; Transcription factor Q00403 2959 1p22.2 human K238-ac 458997 AATHIARkAVELDLV TFIIB molecular association, regulation transcription, altered GTF2F2(INDUCES) 12931194 1 1 0 -Pdpn PDPN Membrane protein, integral Q62011 14726 4|4 E1 mouse S167-p 36491600 IVVMKKIsGRFSP__ Podoplanin cytoskeletal reorganization 25341788 1 0 0 contraction -ELK1 ELK1 DNA-binding; Transcription factor P19419 2002 Xp11.23 human S383-p 447872 IHFWSTLsPIAPRSP activity, induced; molecular association, regulation; intracellular localization; protein conformation carcinogenesis, induced; apoptosis, altered; cell growth, induced; transcription, induced; transcription, altered AurA(INDUCES) DNA(INDUCES) 11145955; 12887893; 20727996; 21258408; 21730285; 23322625; 32034306; 34497368; 8262053; 9130707 45 1 0 -HNF4A HNF4 alpha DNA-binding; Nuclear receptor; Transcription factor P41235 3172 20q13.12 human Y286-p 22996302 LQIDDNEyAYLKAII Hormone_recep protein degradation; intracellular localization; phosphorylation transcription, inhibited 22308320 2 1 0 reduced nuclear localization and protein stability; multistep phosphorylation by Src, phosphorylating Y23 first, which interacts with the Src SH2 domain, followed by phosphorylation of Y286, Y288 -BIRC5 Survivin Apoptosis O15392 332 17q25.3 human T117-p 450947 KNKIAKEtNNKKKEF molecular association, regulation; intracellular localization cell cycle regulation INCENP(INDUCES) 14610074; 17457057 2 0 0 -Ptk2 FAK EC 2.7.10.2; KINASE; Kinase, protein; Protein kinase, TK; Protein kinase, tyrosine (non-receptor) O35346 25614 7q34 rat Y928-p 447966 DRSNDKVyENVTGLV Focal_AT molecular association, regulation; intracellular localization cell motility, induced; cytoskeletal reorganization; signaling pathway regulation PXN(DISRUPTS) 21660950; 25391654 104 17 427 regulates Paxillin localization at FAs; focal adhesion inhibition/dissociation; integrin Rac1-NADPH oxidase signaling -DVL2 DVL2 Adaptor/scaffold; Motility/polarity/chemotaxis O14641 1856 17p13.1 human K343-ub 12338464 VLRDIVHkPGPIVLT PDZ molecular association, regulation; intracellular localization cell motility, induced; signaling pathway regulation Cofilin-1(INDUCES); VANGL1(INDUCES) 31340145 1 6 3 DVL2 variant with all encoded lysine residues mutated to arginine is sufficient to restore WNT activation -GATA1 GATA1 DNA-binding; Transcription factor P15976 2623 Xp11.23 human K246-ac 459077 RPLIRPKkRLIVSKR molecular association, regulation transcription, altered DNA(INDUCES) 16888089 4 0 0 -CAMK2A CAMK2A iso2 EC 2.7.11.17; KINASE; Kinase, protein; Protein kinase, CAMK; Protein kinase, Ser/Thr (non-receptor) Q9UQM7-2 815 5q32 human T286-p 447797 SCMHRQEtVDCLKKF molecular association, regulation; intracellular localization; enzymatic activity, induced NMDAR2B(INDUCES) 28636948 155 34 72 regulates LTP, fear memory, spatial learning -Cyp2e1 CYP2E1 EC 1.14.13.n7; Endoplasmic reticulum; Lipid Metabolism - arachidonic acid; Lipid Metabolism - linoleic acid; Mitochondrial; Oxidoreductase; Xenobiotic Metabolism - drug metabolism - cytochrome P450; Xenobiotic Metabolism - metabolism by cytochrome P450 P05182 25086 1q41 rat S129-p 455561 WKDVRRFsLSILRDW p450 molecular association, regulation HSP70(INDUCES) 12191992 2 7 1 -Nrip1 RIP140 Nuclear receptor co-regulator; Transcription, coactivator/corepressor Q8CBD1 268903 16|16 C3.1 mouse Y436-p 25234801 SSGDESSySNCVPID NRIP1_repr_2 protein degradation; ubiquitination 22388040 1 0 1 regulates inflamatory responses and contributes to endotoxin tolerance -Ric8a RIC8A GEF; GEF, misc. NP_001093990 293614 1q41 rat S523-p 3213324 TMEGQLSsDPDSDPD molecular association, regulation G-alpha i1(INDUCES) 29844055 1 5 0 G-alpha subunit guanine nucleotide exchange; G-alpha subunit folding -Nlrp3 NLRP3 Inhibitor Q8R4B8 216799 11|11 B1.3 mouse S291-p 57761902 CKILRKPsRILFLMD NACHT activity, induced; ubiquitination 27692610; 28716882 4 2 0 activate the NLRP3 iflammasome; inhibits NLRP3 inflammasome activation -Prkaa1 AMPKA1 Autophagy; EC 2.7.11.1; EC 2.7.11.26; EC 2.7.11.27; EC 2.7.11.31; KINASE; Kinase, protein; Protein kinase, CAMK; Protein kinase, Ser/Thr (non-receptor) Q5EG47 105787 15|15 A1 mouse T388-p 7712505 ETPRARHtLDELNPQ autophagy, induced 35256937 2 4 2 -PPP2R5D PPP2R5D Motility/polarity/chemotaxis; PHOSPHATASE; Protein phosphatase, regulatory subunit Q14738 5528 6p21.1 human S60-p 457388 PSSNKRPsNSTPPPT molecular association, regulation; phosphorylation cell cycle regulation PPP2CA(INDUCES) 17110335 5 0 0 enhances dephosphorylation of Cdc25C -Pi4k2a PI4K2A EC 2.7.1.67; Kinase, lipid; Motility/polarity/chemotaxis Q2TBE6 84095 19 C3|19 35.74 cM mouse S5-p 2022753 ___MDETsPLVSPER protein degradation; molecular association, regulation; intracellular localization LAMP1(INDUCES); AP3D1(INDUCES) 25083612 2 12 0 Regulates the lysosomal degradation -BLNK BLNK Adaptor/scaffold Q9YGC1 395733 chicken S170-p 7603529 LPRPKKPsLPSPAAK transcription, altered 19372136 1 1 0 -INPP5D SHIP iso2 EC 3.1.3.86; Motility/polarity/chemotaxis; Phosphatase, lipid Q92835-2 3635 2q37.1 human Y914-p 450030 TEIINPNyMGVGPFG intracellular localization 29852247 3 9 175 nucleocytoplasmic shuttling (A mutants show accumulation in nucleus) -Mknk2 Mnk2 EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, CAMK; Protein kinase, Ser/Thr (non-receptor); Translation Q8CDB0 17347 10|10 C1 mouse T379-p 447642 APENTLPtPLVLQRN enzymatic activity, induced 11154262 1 1 0 -Dnm1l DRP1 Apoptosis; EC 3.6.5.5; Endoplasmic reticulum; Hydrolase; Microtubule-binding; Mitochondrial; Motor O35303 114114 11q23 rat S635-p 454690 PIPIMPAsPQKGHAV activity, induced; intracellular localization cell cycle regulation; apoptosis, induced 17301055; 23798729; 29704468; 33603953; 36315519; 36805606 132 78 114 -PFN1 profilin 1 Actin-binding; Cytoskeletal; Motility/polarity/chemotaxis P07737 5216 17p13.2 human Y60-p 464066 GKDRSSFyVNGLTLG Profilin molecular association, regulation ACTA1(INDUCES) 18573880 1 3 73 -EIF2AK2 PKR EC 2.7.10.2; EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, Other; Protein kinase, Ser/Thr (non-receptor); Protein kinase, tyrosine (non-receptor); Translation P19525 5610 2p22.2 human T90-p 3181643 SPLLLTTtNSSEGLS enzymatic activity, induced 11152499 1 1 0 -DDR1 DDR1 EC 2.7.10.1; KINASE; Kinase, protein; Membrane protein, integral; Protein kinase, TK; Protein kinase, tyrosine (receptor) Q08345 780 6p21.33 human Y797-p 457958 NLYAGDYyRVQGRAV PK_Tyr_Ser-Thr activity, induced 24509848 0 11 303 phosphorylated in the N211QDDR1 mutant -MCM3 MCM3 DNA replication; EC 3.6.4.12 P25205 4172 6p12.2 human S112-p 2840507 SFGSKHVsPRTLTSC MCM_OB molecular association, regulation MCM7(INDUCES) 21658608 3 0 0 -Foxp1 FOXP1 C2H2-type zinc finger protein; Cell cycle regulation; DNA-binding; Transcription factor Q498D1 297480 4q34 rat K670-sm 610814010 AVHPIHVkEEPLDPE molecular association, regulation transcription, inhibited; signaling pathway regulation CTBP1(INDUCES) 28408745 2 1 0 regulates neuronal morphogenesis and development -IQGAP1 IQGAP1 GAP; GAP, Ras; Motility/polarity/chemotaxis P46940 8826 15q26.1 human K1475-ub 12289715 ELGTVDPkNKYQELI RasGAP_C activity, induced; molecular association, regulation cell motility, induced CDC42(INDUCES); RAC1(INDUCES) 32094223 1 4 9 K165R, K175R mutant binding compared to WT, ubiquitination of the GRD likely blocks CDC42 binding; 6KR mutant compared to WT -Caskin1 CASKIN1 Adaptor/scaffold Q8VHK2 140722 10q12 rat Y336-p 4274896 TGNDRVGyFPSSLGE SH3_2 protein conformation 23181695 1 1 0 Phosphorylation leads to structural changes in the SH3 domain. -CALCOCO1 CALCOCO1 Nuclear receptor co-regulator Q9P1Z2 57658 12q13.13 human K29-sm 2887214 RTYIPNTkVECHYTL SKICH transcription, altered 18218142 1 0 0 differential regulation of LEF1 and ER transcription -NUDC NUDC Cell cycle regulation; Cytoskeletal Q9Y266 10726 1p36.11 human T40-p 11164887 FSFLRRKtDFFIGGE Nudc_N cell cycle regulation 27074040 1 0 1 regulates cytokinesis -CAMK2G CAMK2G EC 2.7.11.17; KINASE; Kinase, protein; Protein kinase, CAMK; Protein kinase, Ser/Thr (non-receptor) Q13555 818 10q22.2 human T287-p 467596 SMMHRQEtVECLRKF protein stabilization; intracellular localization; enzymatic activity, induced 19884317; 25303525 6 41 235 induces translocation of HDAC4 and 5; cotransport of Ca2+/CaM to the nucleus along with CaMK2G -EIF4EBP1 4E-BP1 Translation; Translation initiation Q13541 1978 8p11.23 human T46-p 447496 GGTLFSTtPGGTRII eIF_4EBP molecular association, regulation; activity, inhibited; phosphorylation carcinogenesis, induced; carcinogenesis, inhibited; cell growth, inhibited; signaling pathway regulation; translation, altered; autophagy, induced; cell growth, induced; apoptosis, inhibited; autophagy, inhibited; translation, induced 4E-BP1(DISRUPTS); mTOR(DISRUPTS); EIF4E(DISRUPTS) 11799119; 12588975; 15051500; 19036825; 21602434; 21734039; 21750219; 21914810; 22071574; 23542178; 23584478; 24247720; 25361081; 32094692; 34546793; 34673774; 35626002; 35864174; 36652560; 36882522; 37264081; 9465032 156 36 91 -H2ac4 H2A.1 DNA-binding C0HKE1 319172 13|13 A3.1 mouse K119-ub 482913 QAVLLPKkTESHHKA Histone_H2A_C molecular association, regulation; ubiquitination; intracellular localization cell cycle regulation; DNA repair, induced; cell growth, inhibited; transcription, induced; transcription, inhibited DNMT3A(INDUCES) DNA(INDUCES) 26272920; 26716510; 26748827; 33986537; 35640597 48 14 146 H2AK119ub1 at the actively transcribed genes marked by H3K4me3 ; H2AK119ub1 was with other modications and worked with H3K27me3 to inhibit transcription. -AKT1 Akt1 EC 2.7.11.1; KINASE; Kinase, protein; Oncoprotein; Protein kinase, AGC; Protein kinase, Ser/Thr (non-receptor) P31749 207 14q32.33 human K140-m3 1879848300 EMEVSLAkPKHRVTM enzymatic activity, induced carcinogenesis, induced; cell motility, induced JMJD2B(INDUCES); JMJD2A(INDUCES); PDK1(INDUCES); TRAF6(INDUCES) 30692625 1 1 0 interaction of Akt1 with TRAF6, and subsequent Akt ubiquitination ; promotes cell growth and glycolysis -CHEK2 Chk2 EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, CAMK; Protein kinase, Ser/Thr (non-receptor); Tumor suppressor O96017 11200 22q12.1 human K520-p 1877735400 AQPSTSRkRPREGEA phosphorylation; enzymatic activity, induced cell cycle regulation Chk2(INDUCES) 31209362 1 0 0 -Nos3 eNOS Amino Acid Metabolism - arginine and proline; EC 1.14.13.39; Oxidoreductase Q62600 24600 4q11 rat T494-p 447885 TGITRKKtFKEVANA enzymatic activity, inhibited 10025949; 17376767; 34389653; 35954193; 36345832 82 2 1 -EIF4B EIF4B RNA-binding; Translation; Translation initiation P23588 1975 12q13.13 human S422-p 451290 RERSRTGsESSQTGT molecular association, regulation; activity, inhibited carcinogenesis, induced; translation, altered; cell growth, induced; cell growth, inhibited; apoptosis, inhibited; translation, induced eIF3-alpha(INDUCES) 15071500; 16763566; 26848623; 33939688; 36882522 11 54 482 -Prkd2 PRKD2 EC 2.7.11.13; KINASE; Kinase, protein; Motility/polarity/chemotaxis; Protein kinase, CAMK; Protein kinase, Ser/Thr (non-receptor) Q8BZ03 101540 7|7 A2 mouse S707-p 449864 ARIIGEKsFRRSVVG Pkinase exocytosis, induced 21527521 5 10 21 in dense granules, platelet aggregation and thrombus formation -ASAP1 DDEF1 GAP; GAP, ARF; Motility/polarity/chemotaxis Q9ULH1 50807 8q24.21-q24.22 human Y312-p 480743 SQSRQGGySMHQLQG molecular association, regulation; intracellular localization GBF1(INDUCES) 29654145 1 1 1 relocalization of ER chaperones -Cacna1c CACNA1C Channel, calcium; Membrane protein, integral; Membrane protein, multi-pass Q01815 12288 6 F1|6 55.86 cM mouse S1487-p 460572 DYLTRDWsILGPHHL Ion_trans activity, induced 20479240 5 1 0 mediates Ca2+ current facilitation -UBAP2L NICE-4 RNA-binding; Ubiquitin conjugating system Q14157 9898 1q21.3 human R187-m2 27280772 GRGGSGRrGGRFSAQ molecular association, regulation 31114027 1 2 1 regulation of stress-granule dynamics by NICE-4 arginine methylation -Anxa2 ANXA2 Calcium-binding; Lipid-binding; Motility/polarity/chemotaxis P07356 12306 9 C|9 38.58 cM mouse S26-p 450879 TPPSAYGsVKPYTNF phosphorylation carcinogenesis, induced; cell growth, induced; autophagy, inhibited; translation, induced; signaling pathway regulation 35257889; 36739096 14 29 100 induces PI3K and mTOR phosphorylation and hence the PI3K-mTOR signaling -AURKB AurB EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, Other; Protein kinase, Ser/Thr (non-receptor) Q96GD4 9212 17p13.1 human K87-ub 21129744 GRPLGKGkFGNVYLA Pkinase intracellular localization; enzymatic activity, induced 35853811 1 6 0 localization of TbRI in the midbody during cell division -Plk4 PLK4 EC 2.7.11.21; KINASE; Kinase, protein; Nucleolus; Protein kinase, Other; Protein kinase, Ser/Thr (non-receptor) Q64702 20873 3|3 B mouse T289-p 12654002 SMDSGHAtLSTTITA protein degradation; ubiquitination 20100909 1 1 0 -CCNE1 CCNE1 Activator; Cell cycle regulation; Nuclear receptor co-regulator P24864 898 19q12 human T77-p 454411 DPCSLIPtPDKEDDD protein degradation; molecular association, regulation FBXW7(INDUCES) 14536078; 15364936; 17434132 8 1 0 -HNRNPA2B1 hnRNP A2/B1 iso2 RNA splicing; RNA-binding; Spliceosome P22626-2 3181 7p15.2 human K305-ub 1877221605 PSNYGPMkSGNFGGS HnRNPA1 protein degradation carcinogenesis, inhibited; cell growth, inhibited 32826868 1 0 0 -BRAF BRAF EC 2.7.11.1; KINASE; Kinase, protein; Oncoprotein; Protein kinase, Ser/Thr (non-receptor); Protein kinase, TKL Q04982 396239 chicken S365-p 450243 GQRDRSSsAPNVHIN molecular association, regulation; enzymatic activity, inhibited 14-3-3 beta(INDUCES) 16702958 9 27 30 -Grin2c NMDAR2C Channel, calcium; Channel, ligand-gated; Membrane protein, integral; Membrane protein, multi-pass Q01098 14813 11 E2|11 80.8 cM mouse S1084-p 7979604 GPRPRHAsLPSSVAE intracellular localization apoptosis, altered 19477150 2 0 0 important for cell survival -TERF2 TRF2 DNA repair, damage; DNA-binding Q15554 7014 16q22.1 human R70-me 10338217 RSSGRARrGRHEPGL cell cycle regulation; cell growth, altered 19596784 1 0 0 -Abi1 Abi-1 Adaptor/scaffold; Motility/polarity/chemotaxis Q8CBW3 11308 2 A3|2 15.18 cM mouse S216-p 3205884 VPNDYMTsPARLGSQ protein stabilization cell differentiation, inhibited; cytoskeletal reorganization 32673396 3 12 32 Regulate epiblast differentiation and polarizations -XPC XPC DNA repair, damage Q01831 7508 3p25.1 human S129-p 14161729 SNEEEEEsENDWEEV molecular association, regulation GTF2H1(INDUCES) 26029824 1 12 0 -Mcl1 MCL1 Apoptosis; Channel, misc.; Inhibitor; Membrane protein, integral; Mitochondrial P97287 17210 3 F2.1|3 40.74 cM mouse K178-ub 10837359 ATGSKDSkPLGEAGA protein degradation; molecular association, regulation; ubiquitination autophagy, induced beclin 1(DISRUPTS) 28053206; 32094511 4 5 27 -TP53 p53 Activator; DNA-binding; Motility/polarity/chemotaxis; Nuclear receptor co-regulator; Transcription factor; Tumor suppressor P04637 7157 17p13.1 human K381-ub 464657 GQSTSRHkKLMFKTE protein degradation; molecular association, regulation; intracellular localization transcription, inhibited ING1(DISRUPTS) 11046142; 17371868; 19927155; 21731648; 31002112 10 0 0 K370/372/373/381/382/386/R mutant shows 613-fold activation of p53; binds unmodified or six multimonoubiquitinated forms of wild-type p53; translocation of p53 from the nucleus to the cytoplasm, promotes EMT in EOC cells -EPB41 EPB41 iso4 Cytoskeletal P11171-4 2035 1p35.3 human S331-p 451158 RTASKRAsRSLDGAA FA molecular association, regulation; protein conformation cytoskeletal reorganization XK(INDUCES); SPTA1(DISRUPTS); DARC(INDUCES); GPC1(INDUCES) 21542582 3 14 0 interactions are induced by phosphorylation of either of the sites -SHC3 SHC3 iso2 Adaptor/scaffold; Motility/polarity/chemotaxis Q92529-2 53358 9q22.1 human Y301-p 451259 PTGEAPTyVNTQQIP activity, induced; molecular association, regulation; phosphorylation transcription, altered DYN1(INDUCES); SOS1(INDUCES); GRB2(INDUCES) 11791173; 16126371 3 0 1 ERK activation -PDE4D PDE4D iso2 EC 3.1.4.53; Nucleotide Metabolism - purine; Phosphodiesterase Q08499-2 5144 5q11.2-q12.1 human S239-p 469621 KKLMHSSsLTNSSIP enzymatic activity, induced 16973330 2 12 6 switches the effect of S579 phosphorylation from inhibition to activation -Nrip1 RIP140 Nuclear receptor co-regulator; Transcription, coactivator/corepressor Q8CBD1 268903 16|16 C3.1 mouse T207-p 455626 GPTLPDVtPNLIRDS NRIP1_repr_1 activity, induced; molecular association, regulation; acetylation; intracellular localization cell differentiation, induced; transcription, inhibited p300(INDUCES) 16093479; 18655826 2 3 0 increases acetylation of RIP140 at K158 and K287 -SMPD1 SMPD1 EC 3.1.4.12; Lipid Metabolism - sphingolipid; Phosphodiesterase P17405 6609 11p15.4 human S510-p 477185 DGNYSGSsHVVLDHE ASMase_C intracellular localization; enzymatic activity, induced apoptosis, induced 17303575; 17698617 2 0 0 -Ifnar2 IFNAR2 Membrane protein, integral; Receptor, cytokine O35664 15976 16 C3.3|16 52.82 cM mouse Y510-p 3063304 DADVGDGyIMR____ phosphorylation signaling pathway regulation 36118237 5 0 0 induces STAT phosphorylation and signaling -KDM3A JMJD1A DEMETHYLASE; Demethylase; EC 1.14.11.-; Nuclear receptor co-regulator; Oxidoreductase Q9Y4C1 55818 2p11.2 human K918-ub 12301471 FASLVQNkTTSDLSK intracellular localization DNA repair, induced; cell growth, induced; transcription, induced 32238799 1 5 11 recruitment of p300 to c-Myc for the expression of DDR genes, resistance of prostate cancer cells to genotoxic stress -TIAM1 TIAM1 GEF; GEF, Rac/Rho; Motility/polarity/chemotaxis; Oncoprotein Q13009 7074 21q22.11 human S60-p 11485305 EVSTRSSsTPSIPQS protein stabilization; molecular association, regulation 14-3-3 beta(INDUCES) 25746002 2 1 0 -Bub1b BUB1B EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, Other; Protein kinase, Ser/Thr (non-receptor); Tumor suppressor Q9Z1S0 12236 2|2 E5 mouse T669-p 484623 IEESREAtHSSGFSR phosphorylation 26028219 5 0 0 decrease CASC5 phosphorylation -RIGI RIGI EC 3.6.4.13; Hydrolase O95786 23586 9p21.1 human T667-p 63044900 ILTGRGKtNQNTGMT Helicase_C molecular association, regulation; activity, inhibited RNA(DISRUPTS) 28132841 1 1 0 -Src Src EC 2.7.10.2; KINASE; Kinase, protein; Oncoprotein; Protein kinase, TK; Protein kinase, tyrosine (non-receptor) P05480 20779 2 H1|2 78.35 cM mouse Y138-p 450213 TGYIPSNyVAPSDSI cell cycle regulation; cell growth, altered 8663329 3 0 0 -DACH1 DACH1 DNA-binding; Motility/polarity/chemotaxis; Transcription factor Q9UI36 1602 13q21.33 human S491-p 4782162 IKERVPDsPSPAPSL intracellular localization; activity, inhibited translation, inhibited 24335958 1 7 0 Repression of Snail 5' UTR-Luc reporter -Tnni3 TNNI3 Actin-binding; Motility/polarity/chemotaxis; Motor P48787 21954 7 A1|7 2.61 cM mouse S43-p 450690 AKKKSKIsASRKLQL activity, induced; activity, inhibited; protein conformation cell motility, altered; cytoskeletal reorganization 12003851; 12181153; 12923217; 14726296; 17010989; 19426736; 20083117; 22527640 24 2 0 slows rate of contraction and relaxation -PHLPP1 PHLPP EC 3.1.3.16; PHOSPHATASE; Protein phosphatase, Ser/Thr (non-receptor); Tumor suppressor O60346 23239 18q21.33 human T451-p 3952371 APGGLQStPGRSGVT cell cycle regulation 33397691 1 2 5 -RMI2 RMI2 DNA replication Q96E14 116028 16p13.13 human S112-p 29606701 MGVVQACsPEPCLQA RMI2 cell cycle regulation 24108125 1 1 0 genome stability -APOBEC3G APOBEC3G EC 3.5.4.-; Hydrolase; RNA processing; RNA-binding Q9HC16 60489 22q13.1 human K303-ub 11956703 AKFISKNkHVSLCIF NAD2 protein degradation 19887642 1 0 0 -Cdkn2a p14ARF SUMO LIGASE; SUMO conjugating system Q64364 12578 4 C4|4 42.15 cM mouse S71-p 50440900 GDDDGQRsRSSSSAQ protein degradation; molecular association, regulation; ubiquitination FBW1B(INDUCES) 26240281 1 0 0 -JUP CTNNG Cytoskeletal; Motility/polarity/chemotaxis P14923 3728 17q21.2 human Y644-p 456973 RNEGTATyAAAVLFR molecular association, regulation transcription, induced CDH1(DISRUPTS); CTNNA1(DISRUPTS); Desmoplakin(INDUCES) 14517306 1 1 29 -CTNNB1 CTNNB1 Actin-binding; Cell adhesion; Motility/polarity/chemotaxis; Nuclear receptor co-regulator; Oncoprotein; Transcription factor P35222 1499 3p22.1 human S191-p 467710 SRHAIMRsPQMVSAI protein stabilization; molecular association, regulation; intracellular localization; protein conformation transcription, induced PIN1(INDUCES) 26740630 5 45 11 nuclear retention -PCYT1A PCYT1A EC 2.7.7.15; Lipid Metabolism - glycerophospholipid; Transferase P49585 5130 3q29 human K57-ub 7761224 EIEVDFSkPYVRVTM protein degradation; molecular association, regulation; intracellular localization KPNA1(DISRUPTS) 19332566 1 2 0 -SUN1 SUN1 Cytoskeletal; Membrane protein, integral O94901 23353 7p22.3 human S55-p 179463700 SPRMSRRsLRLATTA molecular association, regulation NXF1(DISRUPTS) 28831067 1 0 0 mRNA export -XPO5 Exportin-5 Karyopherin; Nuclear export; Nuclear import; RNA-binding Q9HAV4 57510 6p21.1 human S497-p 59179701 GSLCSVFsPSFVQWE Exportin-5 protein conformation 29445125 1 0 0 isomerization of phosphorylated peptide by Pin1 in vitro -CPLX1 CPLX1 Vesicle Q0IIL7 768228 cow S115-p 474557 AAEEEDEsILDTVIK Synaphin molecular association, regulation STX1A(INDUCES) 17266930 2 1 1 SNARE complex summarized by Syntaxin binding. -Tom1l1 Srcasm Adaptor/scaffold Q923U0 71943 11 D|11 55.47 cM mouse S320-p 3177419 SCDLLDLsPIVPVPT molecular association, regulation TOLLIP(INDUCES) 26899482 1 15 0 peripheral localization, ECM degradation and invasion -KCNE1 KCNE1 Channel, potassium; Membrane protein, integral P15382 3753 21q22.12 human S102-p 10349700 VQARVLEsYRSCYVV ISK_Channel activity, induced; receptor internalization, induced; activity, inhibited endocytosis, induced 21699843; 29452158; 32833978; 33373586 5 0 0 induces voltage-gated current and hence activity of TMEM16A; downregulates IKs by stimulating KCNQ1-KCNE1 channel endocytosis -EPHA2 EphA2 EC 2.7.10.1; KINASE; Kinase, protein; Membrane protein, integral; Protein kinase, TK; Protein kinase, tyrosine (receptor) P29317 1969 1p36.13 human Y735-p 473293 KYLANMNyVHRDLAA PK_Tyr_Ser-Thr molecular association, regulation cell differentiation, altered; cell motility, altered PIK3R1(INDUCES) 18387945 1 4 17 -EGLN1 EGLN1 EC 1.14.11.29; Oxidoreductase Q9GZT9 54583 1q42.2 human S136-p 1877121600 AAAGGQGsAVAAEAE enzymatic activity, inhibited signaling pathway regulation 35538889 1 1 0 regulates PHD2/HIFa/hepcidin/ferroportin signalling -FOXC2 FOXC2 Apoptosis; Cell development/differentiation; DNA-binding; Transcription factor Q99958 2303 16q24.1 human S219-p 3210576 VIKSEAAsPALPVIT molecular association, regulation transcription, altered DNA(INDUCES) 23878394 1 18 1 implicated in vascular remodeling in vivo -FOXM1 FOXM1 DNA-binding; Transcription factor Q08050 2305 12p13.33 human K460-sm 31898501 LLPVQTIkEEEIQPG protein degradation; ubiquitination; intracellular localization cell cycle regulation; cell growth, inhibited; transcription, inhibited 24362530 2 2 0 -ARAF ARAF EC 2.7.11.1; KINASE; Kinase, protein; Oncoprotein; Protein kinase, Ser/Thr (non-receptor); Protein kinase, TKL P10398 369 Xp11.3 human S214-p 3180426 LQRIRSTsTPNVHMV enzymatic activity, induced 18662992 1 5 25 -FANCD2 FANCD2 DNA repair, damage Q9BXW9 2177 3p25.3 human T884-p 1871613603 SKTSSSDtLSEEKNS FancD2 molecular association, regulation; ubiquitination; intracellular localization; activity, inhibited cell cycle regulation; DNA repair, inhibited; signaling pathway regulation DNA(DISRUPTS) 31167143 1 1 0 inhibits Fanconi anemia pathway leading to inhibition of DNA repair; 882-898 cluster -LEF1 LEF-1 DNA-binding; Transcription factor Q9UJU2 51176 4q25 human T155-p 11499001 SHAVHPLtPLITYSD CTNNB1_binding activity, induced; molecular association, regulation transcription, induced; signaling pathway regulation; transcription, inhibited HDAC1(DISRUPTS) 12556497; 22373574 3 1 10 Wnt/beta-catenin signalling pathway -Myog myogenin DNA-binding; Transcription factor P12979 17928 1 E4|1 58.18 cM mouse T87-p 451161 VDRRRAAtLREKRRL HLH activity, induced 14966278 1 0 0 affects muscle innervation rates -Pip5k1c PIP5K1C Carbohydrate Metabolism - inositol phosphate; EC 2.7.1.68; Kinase, lipid; Motility/polarity/chemotaxis O70161 18717 10|10 C1 mouse S645-p 457599 DERSWVYsPLHYSAR molecular association, regulation endocytosis, inhibited AP-2 alpha(DISRUPTS) 22243752 2 1 0 -RUNX1 AML1 DNA-binding; Oncoprotein; Transcription factor Q01196 861 21q22.12 human K144-ub 95155310 VGRSGRGkSFTLTIT Runt protein degradation; intracellular localization carcinogenesis, inhibited; cell growth, inhibited; transcription, inhibited 28536267 1 0 0 -RBM25 RBM25 RNA splicing; RNA-binding; Spliceosome P49756 58517 14q24.2 human K77-me 1873076616 DHPGLKAkENDENCG molecular association, regulation SFRS2(DISRUPTS) 28655759 0 1 0 promotes inclusion of alternatively spliced exons -TDG TDG DNA repair, damage; EC 3.2.2.29; Hydrolase; Nuclear receptor co-regulator Q13569 6996 12q23.3 human K330-sm 3144814 DAKKMAVkEEKYDPG molecular association, regulation; protein conformation; enzymatic activity, induced DNA repair, induced; DNA repair, altered DNA(DISRUPTS) 11889051; 15823533; 15959518; 21284855 5 3 0 -HDAC2 HDAC2 DEACETYLASE; Deacetylase; EC 3.5.1.98; Nuclear receptor co-regulator; Transcription, coactivator/corepressor P56519 395635 chicken S407-p 476456 EDPDKRIsIRASDKR molecular association, regulation MBD3(INDUCES); MTA1(INDUCES); HDAC2(INDUCES) 33596269 1 7 4 promotes homodimerization -SAFB SAFB1 DNA-binding; Nuclear receptor co-regulator; RNA-binding Q15424 6294 19p13.3 human K226-m1 58123205 DILGETCkSEPVKEE molecular association, regulation L3MBTL iso4(INDUCES) 23583077 0 1 0 -SDHA SDHA Carbohydrate Metabolism - citrate (TCA) cycle; EC 1.3.5.1; Energy Metabolism - oxidative phosphorylation; Mitochondrial; Oxidoreductase; Tumor suppressor P31040 6389 5p15.33 human K179-ac 461207 AFGGQSLkFGKGGQA FAD_binding_2 enzymatic activity, inhibited 26998524 3 8 8 -SMURF2 SMURF2 EC 6.3.2.-; EC 6.3.2.19; Ligase; UBIQUITIN LIGASE; Ubiquitin conjugating system; Ubiquitin ligase Q9HAU4 64750 17q23.3-q24.1 human R237-m1 56854403 ERRVRSQrHRNYMSR protein degradation 26126536 1 0 0 -Tdg TDG DNA repair, damage; EC 3.2.2.29; Hydrolase; Nuclear receptor co-regulator P56581 21665 10 C1|10 39.72 cM mouse S99-p 11509300 TSKKSGKsTKSKEKQ molecular association, regulation; acetylation DNA repair, induced DNA(INDUCES) 19966277 1 0 0 inhibits acetylation at other sites -MEF2D MEF2D DNA-binding; Transcription factor Q14814 4209 1q22 human S110-p 470517 GEDSLEQsPLLEDKY HJURP_C molecular association, regulation; ubiquitination SKP2(INDUCES) 25733682 1 9 3 -SPAST spastin Cytoskeletal; EC 3.6.4.3; Membrane protein, integral Q9UBP0 6683 2p22.3 human K554-ub 27210454 SDLTALAkDAALGPI AAA_lid_3 protein degradation 33106322 1 1 0 -Dact1 DACT1 Adaptor/scaffold Q8R4A3 59036 12|12 C3 mouse S704-p 1833062500 GDSESSVsEGDFVGE Dapper signaling pathway regulation 31978940 1 0 0 Wnt signaling pathway -KCNA3 Kv1.3 Channel, potassium; Membrane protein, integral; Membrane protein, multi-pass P22001 3738 1p13.3 human Y163-p 3820936 FDAILYYyQSGGRIR BTB_2 activity, inhibited 19166614 1 0 0 -ERBB3 HER3 EC 2.7.10.1; KINASE; Kinase, protein; Membrane protein, integral; Oncoprotein; Protein kinase, TK; Protein kinase, tyrosine (receptor) P21860 2065 12q13.2 human Y1260-p 449860 GTTPDEDyEYMNRQR molecular association, regulation carcinogenesis, induced; cell motility, induced PIK3R2(INDUCES); PIK3R1(INDUCES) 16729043; 21725367 3 0 16 chemotaxis and invasion -WEE1 Wee1 EC 2.7.10.2; KINASE; Kinase, protein; Protein kinase, Other; Protein kinase, Ser/Thr (non-receptor); Protein kinase, tyrosine (non-receptor) P30291 7465 11p15.4 human S121-p 456468 WEEEGFGsSSPVKSP protein degradation; molecular association, regulation BTRC(INDUCES) 16085715 2 0 0 -Itch ITCH EC 6.3.2.-; EC 6.3.2.19; Ligase; UBIQUITIN LIGASE; Ubiquitin conjugating system; Ubiquitin ligase Q8C863 16396 2 H1|2 76.94 cM mouse T222-p 459624 PSRPPPPtPRRPASV protein stabilization; protein conformation 16446428 3 0 0 -MLLT1 MLLT1 Oncoprotein; Transcription regulation Q03111 4298 19p13.3 human S394-p 40666501 SDSDFEPsQNHSQGP molecular association, regulation transcription, inhibited BMI1(INDUCES) 25921070 1 0 0 -Dusp9 DUSP9 EC 3.1.3.16; EC 3.1.3.48; Motility/polarity/chemotaxis; PHOSPHATASE; Protein phosphatase, dual-specificity Q7TNL7 75590 X|X A7.3 mouse S58-p 22694400 LRRLRRGsMSVRSLL Rhodanese molecular association, regulation; enzymatic activity, inhibited signaling pathway regulation ERK2(DISRUPTS); P38A(DISRUPTS) 21908610 1 0 0 regulates MAPK signaling pathway -H4C1 H4 DNA-binding P62805 8359 6p22.2 human K20-me 4145502 GGAKRHRkVLRDNIQ CENP-T_C acetylation 12208845 8 0 0 inhibits K16 acetylation -SCN5A SCN5A Channel, sodium; Membrane protein, integral; Membrane protein, multi-pass Q14524 6331 3p22.2 human S1503-p 9993604 NAMKKLGsKKPQKPI intracellular localization; activity, inhibited 22101522; 32209328 4 1 0 NR decreased current in K1479A SCN5A, but increased INa. Disruption of S1503 site abolished effect on INa.; regulating intracellular Na+channel localization, and the rate of intrcecellular trafficking ; NR increased current, INa -IER3 IEX-1 Apoptosis; Membrane protein, integral P46695 8870 6p21.33 human T18-p 455559 MTILQAPtPAPSTIP apoptosis, inhibited 12356731 1 2 0 -HIPK2 HIPK2 EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, CMGC; Protein kinase, Ser/Thr (non-receptor) Q9H2X6 28996 7q34 human T360-p 8086452 VSKAVCStYLQSRYY Pkinase molecular association, regulation; enzymatic activity, induced apoptosis, induced; signaling pathway regulation ASK1(INDUCES); JNK2(INDUCES) 27321923 1 5 18 HIPK2 and JNK activation -TET2 TET2 EC 1.14.11.n2; Oxidoreductase; Tumor suppressor Q6N021 54790 4q24 human Y1939-p 1870020000 CEKYGPDyVPQKSHG activity, induced; molecular association, regulation cell differentiation, induced; signaling pathway regulation KLF1(INDUCES) 30944118 1 0 0 -AHR AHR DNA-binding; Transcription factor P35869 196 7p21.1 human S693-p 1874101924 PYKSEMDsMPYTQNF protein degradation; ubiquitination autophagy, induced; transcription, induced 34198826 1 0 0 -RAD51 RAD51 DNA repair, damage; Mitochondrial Q06609 5888 15q15.1 human S14-p 23305001 LEANADTsVEEESFG activity, induced; molecular association, regulation; intracellular localization; phosphorylation cell cycle regulation; DNA repair, induced BRCA2(INDUCES) DNA(INDUCES) 22325354; 24835992; 34197606 5 1 0 -UBE2I UBC9 EC 6.3.2.-; EC 6.3.2.19; Ligase; Nuclear receptor co-regulator; SUMO LIGASE; SUMO conjugating system; SUMO ligase; UBIQUITIN LIGASE; Ubiquitin conjugating system; Ubiquitin ligase P63279 7329 16p13.3 human K49-sm 14512106 ECAIPGKkGTPWEGG UQ_con sumoylation; molecular association, regulation signaling pathway regulation RASD2(INDUCES) 20424159; 27501389 2 7 0 TTR specifically modulates general protein SUMOylation; RASD2 enhances sumoylation, induces sumoylation of SP100 -KCNJ2 KCNJ2 Channel, potassium; Membrane protein, integral; Membrane protein, multi-pass P63252 3759 17q24.3 human S425-p 10892807 PRPLRREsEI_____ activity, inhibited 19843922 1 0 0 reduces an inward rectifier current of Kir2.1 V227F -Kcnn4 KCNN4 Channel, potassium; Membrane protein, integral; Membrane protein, multi-pass Q9QYW1 65206 1q21 rat S332-p 452145 KHTRRKDsRAARRHQ CaMBD activity, inhibited Calmodulin(DISRUPTS) 15243742; 25274816 3 0 0 inhibits channel current, inhibits Ca++ influx -ACLY ACLY Carbohydrate Metabolism - citrate (TCA) cycle; EC 2.3.3.8; Lyase; Transferase P53396 47 17q21.2 human K546-ac 11323411 QKFYWGHkEILIPVF CoA_binding protein stabilization; molecular association, regulation; ubiquitination carcinogenesis, induced; cell growth, induced UBR4(INDUCES) 23932781; 31197036 2 3 0 inhibits ubiquitination, high glucose decreases interaction -TNIP1 TNIP1 Transcription regulation Q15025 10318 5q33.1 human S122-p 1880462800 KPPSSGTsSEFEVVT protein degradation; molecular association, regulation; ubiquitination autophagy, induced; transcription, induced LC3B(INDUCES); LC3C(INDUCES); GABARAPL2(INDUCES) 36574265 1 1 0 -NUMB NUMB iso3 Cell development/differentiation P49757-3 8650 14q24.2-q24.3 human S265-p 456490 EQLARQGsFRGFPAL NumbF molecular association, regulation; intracellular localization endocytosis, inhibited AP2A1(DISRUPTS); CDH1(DISRUPTS); CTNND1(DISRUPTS) 21775625 4 18 7 -GRIA1 GluR1 Channel, calcium; Channel, ligand-gated; Membrane protein, integral; Membrane protein, multi-pass P42261 2890 5q33.2 human S834-p 9486201 EFCYKSRsESKRMKG molecular association, regulation; intracellular localization EPB41L1(INDUCES) 19503082 1 0 0 enhances receptor insertion into plasma membrane -DRD2 DRD2 GPCR, family 1; Membrane protein, integral; Membrane protein, multi-pass; Receptor, GPCR P14416 1813 11q23.2 human S229-p 487433 RVNTKRSsRAFRAHL 7tm_1 receptor desensitization, induced 17869243 2 0 0 -Ppargc1a PGC-1 alpha Nuclear receptor co-regulator; Transcription, coactivator/corepressor O70343 19017 5|5 C1 mouse K183-sm 9859927 RTNPAIVkTENSWSN transcription, inhibited 19625249 1 0 0 -Ppp2r1a PPP2R1A Motility/polarity/chemotaxis; PHOSPHATASE; Protein phosphatase, regulatory subunit Q76MZ3 51792 17|17 A3.2 mouse S401-p 1880515600 VIGIRQLsQSLLPAI molecular association, regulation; protein conformation; phosphorylation cell cycle regulation; DNA repair, altered; signaling pathway regulation Exportin-1(INDUCES); Akt1(DISRUPTS) 36434396 1 0 0 induces AKT phosphorylation, regulates AKT and ERK signaling -GLO1 GLO1 Carbohydrate Metabolism - pyruvate; EC 4.4.1.5; Lyase Q04760 2739 6p21.2 human T107-p 7106304 ELTHNWGtEDDETQS Glyoxalase molecular association, regulation; protein stabilization; ubiquitination; enzymatic activity, inhibited; protein conformation; enzymatic activity, induced Other(DISRUPTS) 32966793; 33459186 3 0 0 disrupts binding to Hemimercaptal; inhibits ubiquitination -Ulk1 ULK1 Autophagy; EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, Other; Protein kinase, Ser/Thr (non-receptor) NP_001101811 360827 12q16 rat S757-p 483139 PVVFTVGsPPSGTTP autophagy, inhibited 33473012; 33571535 78 15 2 -RTCB RTCB EC 6.5.1.3 Q9Y3I0 51493 22q12.3 human Y475-p 1876333510 MEEAPESyKNVTDVV RtcB molecular association, regulation RNA splicing, inhibited Other(DISRUPTS) 35193953 1 1 0 inhibits binding to GTP -TP73 p73 DNA-binding; Transcription factor; Tumor suppressor O15350 7161 1p36.32 human K331-ac 460607 AASKRAFkQSPPAVP molecular association, regulation cell growth, inhibited; apoptosis, induced; transcription, induced DNA(INDUCES) 11804596 1 0 0 induces binding to p53AIP1 gene and induces its transcription, but retains an intact ability to regulate genes. -TRIM28 TIF1B EC 6.3.2.-; KINASE; Kinase, protein; Ligase; Nuclear receptor co-regulator; Protein kinase, atypical; SUMO LIGASE; SUMO ligase; Transcription, coactivator/corepressor; UBIQUITIN LIGASE; Ubiquitin conjugating system; Ubiquitin ligase Q13263 10155 19q13.43 human Y458-p 454817 FGSGDDPySSAEPHV molecular association, regulation; phosphorylation DNA repair, induced HP1 alpha(INDUCES) DNA(NOT_REPORTED) 23645696 1 9 107 stimulates phosphorylation of TIF1B S473 and TIF1B S824 in DNA damage response; involved in DNA damage response; inhibits association of HP1alpha with chromatin -ESR1 ER-alpha DNA-binding; Nuclear receptor; Transcription factor P03372 2099 6q25.1-q25.2 human S47-p 12127400 GEVYLDSsKPAVYNY Oest_recep activity, induced transcription, altered 20043841 1 0 0 -Runx2 AML3 DNA-binding; Transcription factor Q08775 12393 17 B3|17 21.33 cM mouse S107-p 3053615 PSTSRRFsPPSSSLQ protein stabilization; molecular association, regulation transcription, induced USP24(INDUCES); SRC-3(INDUCES); p300(INDUCES) DNA(INDUCES) 37415159 8 14 1 -JUN Jun Oncoprotein; Transcription factor P05412 3725 1p32.1 human T93-p 450449 GHITTTPtPTQFLCP Jun molecular association, regulation; activity, inhibited carcinogenesis, altered; transcription, inhibited; transcription, altered; cell growth, altered MBD3(DISRUPTS); TCF4(DISRUPTS) DNA(DISRUPTS) 12853483; 21177766; 36253406; 7744008 9 3 0 -AKAP8 AKAP8 Adaptor/scaffold; Cell cycle regulation; Mitochondrial; RNA-binding O43823 10270 19p13.12 human Y311-p 3582467 KRKQFQLyEEPDTKL molecular association, regulation 25770215 1 2 31 Phenylalanine mutants inhibited dissociation from nuclear structures; structural chromatin changes -Numb NUMB Cell development/differentiation Q9QZS3 18222 12|12 D1 mouse S295-p 470030 SPFKRQLsLRINELP NumbF molecular association, regulation endocytosis, induced; cell motility, induced TrkA(INDUCES) 21571219 4 9 17 -ANXA2 ANXA2 Calcium-binding; Lipid-binding; Motility/polarity/chemotaxis Q6TEQ7 403435 dog Y24-p 449483 HSTPPSAyGSVKAYT cell motility, altered; cytoskeletal reorganization 18070928 29 64 2613 involved in the ROCK/LIMK-dependent dephosphorylation/activation of cofilin; regulates F-actin organization and dynamics -HMGN1 HMGN1 DNA-binding; Nuclear receptor co-regulator P05114 3150 21q22.2 human K48-ac 458849 AKDKSSDkKVQTKGK HMG14_17 molecular association, regulation DNA(DISRUPTS) 10753971 1 0 0 -TWIST1 TWIST1 Cell development/differentiation; DNA-binding; Inhibitor; Transcription regulation Q15672 7291 7p21.1 human S144-p 41455181 TLPSDKLsKIQTLKL HLH protein stabilization; ubiquitination 30733340 1 1 0 ; inhibits TWIST1 ubiquitination -Lrrk2 LRRK2 EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, Ser/Thr (non-receptor); Protein kinase, TKL Q5S006 66725 15|15 E3 mouse S955-p 4725908 RKRKILSsDESLRSS enzymatic activity, inhibited; phosphorylation autophagy, induced 33055242; 37454104 15 7 0 -Nrip1 RIP140 Nuclear receptor co-regulator; Transcription, coactivator/corepressor Q8CBD1 268903 16|16 C3.1 mouse R650-m1 2363401 SGPGEEQrPCKQLLS NRIP1_repr_2 transcription, induced 19216533 2 2 0 -SMAD4 SMAD4 DNA-binding; Nuclear receptor co-regulator; Transcription, coactivator/corepressor Q13485 4089 18q21.2 human Y322-p 1881244704 SNHPAPEyWCSIAYF molecular association, regulation cell cycle regulation; carcinogenesis, induced; cell growth, induced; transcription, inhibited p300(DISRUPTS); CBP(DISRUPTS); H3(DISRUPTS) 36959211 1 1 0 binding to p300 promotes p300 binding to DNA -CAMK1 CAMK1A EC 2.7.11.17; KINASE; Kinase, protein; Protein kinase, CAMK; Protein kinase, Ser/Thr (non-receptor) Q14012 8536 3p25.3 human K59-ub 28070705 AKEALEGkEGSMENE Pkinase protein degradation 23707388 1 0 0 -AKAP8 AKAP8 Adaptor/scaffold; Cell cycle regulation; Mitochondrial; RNA-binding O43823 10270 19p13.12 human Y436-p 40420003 TVEFLQEyIVNRNKK AKAP95 molecular association, regulation 25770215 1 1 0 Phenylalanine mutants inhibited dissociation from nuclear structures; structural chromatin changes -NUMA1 NuMA-1 Cell cycle regulation; Motility/polarity/chemotaxis Q14980 4926 11q13.4 human S1991-p 487347 RQQRKRVsLEPHQGP cell growth, induced; apoptosis, inhibited 23097092 2 28 42 cell proliferation increased -Eef2 EEF2 Translation; Translation elongation P58252 13629 10|10 C1 mouse T57-p 448040 RAGETRFtDTRKDEQ GTP_EFTU translation, altered 18614030 39 61 54 induces Arc/Arg 3.1 translation -CHEK2 Chk2 EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, CAMK; Protein kinase, Ser/Thr (non-receptor); Tumor suppressor O96017 11200 22q12.1 human T383-p 447545 GETSLMRtLCGTPTY Pkinase ubiquitination; intracellular localization; protein conformation; enzymatic activity, induced 11390408; 12805407; 16794575; 17698850; 20713355 9 2 6 -Smarcd3 SMARCD3 Nuclear receptor co-regulator; Transcription, coactivator/corepressor Q6P9Z1 66993 5|5 A3 mouse T229-p 8097074 HLVEWHRtPTTQETD molecular association, regulation chromatin organization, altered; cell differentiation, induced; transcription, induced SMARCA4(INDUCES) 22068056 1 0 0 -SPRY2 SPRY2 Adaptor/scaffold; Inhibitor; Motility/polarity/chemotaxis O43597 10253 13q31.1 human S121-p 465676 VSSGSRSsTRTSTSS molecular association, regulation; protein stabilization; ubiquitination BRAF(DISRUPTS); NEDD4 iso4(INDUCES) 16479008; 19690147; 19864419 3 1 0 phosphorylation of this site stabilizes protein by interfering with Y55 phosphorylation, Cbl binding and polyubiquitination ; B-Raf V600E oncogenic mutant does not associate with Spry2 (altered kinase domain conformation); interaction with NEDD4 increases the ubiquitination of Spry2 -BRIP1 BRIP1 EC 3.6.4.13; Helicase; Oncoprotein Q9BX63 83990 17q23.2 human S990-p 451461 IVISRSTsPTFNKQT molecular association, regulation cell cycle regulation BRCA1(NOT_REPORTED); BRCA1(INDUCES) 14576433; 15125843; 20173781; 22792074 6 13 0 -RUNX2 AML3 DNA-binding; Transcription factor Q13950 860 6p21.1 human S275-p 10892803 PSLNSAPsPFNPQGQ molecular association, regulation osterix(INDUCES) 25122769 5 4 0 -MAK MAK EC 2.7.11.22; KINASE; Kinase, protein; Nuclear receptor co-regulator; Protein kinase, CMGC; Protein kinase, Ser/Thr (non-receptor) P20794 4117 6p24.2 human Y159-p 462317 SQPPYTDyVSTRWYR Pkinase phosphorylation; enzymatic activity, induced cell cycle regulation 21986944 1 6 805 phosphorylates myelin basic proteins and CDH1 -MPIG6B G6B Immunoglobulin superfamily; Membrane protein, integral; Receptor, misc. O95866 80739 6p21.33 human Y211-p 10296403 DQEPSLLyADLDHLA G6B molecular association, regulation CSK(INDUCES); Src(INDUCES); Syk(INDUCES); SHP-2(INDUCES); SHP-1(INDUCES); Fyn(INDUCES); PLCG2(INDUCES); PIK3CA(INDUCES) 11544253; 23185356 3 1 4 ~70% shifting from the unbound to the bound SHP-2 fraction for the dual phosphopeptide, and ~50% and ~25% binding to the Y211 and Y237 phosphopeptides, respectively; little or no association with the individual Y211 or Y237 phosphopeptides; Only ~30% of the tandem SH2 domains of SHP-1 bound to the dual phosphopeptide -PEX5 PEX5 Membrane protein, integral; Receptor, protein translocating P50542 5830 12p13.31 human S141-p 50389701 DYNETDWsQEFISEV molecular association, regulation; ubiquitination SQSTM1(INDUCES) 26344566 1 0 0 phosphorylated at S141 becomes ubiquitylated at K209, binding to SQSTM1, and directing the autophagosome to peroxisomes to induce pexophagy -Atxn3 ataxin-3 DEUBIQUITINASE; DNA repair, damage; EC 3.4.19.12; Protease; Transcription regulation; Ubiquitin-specific protease Q9CVD2 110616 12|12 E mouse S29-p 13421402 LLQGEYFsPVELSSI Josephin intracellular localization 20347968 1 1 0 -KPNA2 KPNA2 Karyopherin; Nuclear import; Nucleoporin P52292 3838 17q24.2 human S62-p 459854 SFPDDATsPLQENRN IBB molecular association, regulation; intracellular localization cell cycle regulation; chromatin organization, altered; cytoskeletal reorganization NuMA-1(DISRUPTS); TPX2(DISRUPTS); KPNB1(DISRUPTS); KIFC1(DISRUPTS); GM130(INDUCES) 31434716; 33526712 2 69 2 -SIRT1 SIRT1 Apoptosis; DEACETYLASE; Deacetylase; EC 3.5.1.-; Nuclear receptor co-regulator Q96EB6 23411 10q21.3 human S47-p 452899 DGPGLERsPGEPGGA activity, induced; protein stabilization; intracellular localization; enzymatic activity, induced carcinogenesis, induced; DNA repair, induced; cell growth, induced; apoptosis, inhibited; transcription, induced; signaling pathway regulation p53(INDUCES) 20027304; 23754392; 34153425; 34188177 8 49 9 induces deacetylation of p53; expression and regulation of SIRT1 target antioxidative and anti-inflammatory genes increased -ICAM1 ICAM1 Cell adhesion; Immunoglobulin superfamily; Membrane protein, integral P05362 3383 19p13.2 human Y512-p 450460 RQRKIKKyRLQQAQK molecular association, regulation; protein processing cell motility, altered; cell adhesion, altered SHP-2(INDUCES) 10864922; 12902516; 14973144 5 0 1 -IRAK1 IRAK1 EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, Ser/Thr (non-receptor); Protein kinase, TKL P51617 3654 Xq28 human T381-p 394791400 QSSMVARtQTVRGTL Pkinase enzymatic activity, induced 29208712 0 1 0 -HDAC7 HDAC7 DEACETYLASE; Deacetylase; EC 3.5.1.98; Hydrolase Q8WUI4 51564 12q13.11 human S486-p 452459 RPLSRAQsSPAAPAS intracellular localization cell motility, altered; cytoskeletal reorganization; transcription, altered; cell growth, altered 15623513; 18509061; 18617643 7 31 66 important for VEGF-induced aorta ring angiogenesis; nucleo-cytoplasmic shuttling -DLGAP5 DLG7 Cell cycle regulation; Microtubule-binding Q15398 9787 14q22.3 human R122-me 1883354001 RGIFKVGrYRPDMPC intracellular localization cell motility, inhibited 36250981 1 0 0 GR (Golgi apparatus [GA]) repositioning, 122K mutant stimulated CR (centrosome repositioning), GR and cell migration -SCN5A SCN5A Channel, sodium; Membrane protein, integral; Membrane protein, multi-pass Q14524 6331 3p22.2 human S484-p 3799157 KRRKRMSsGTEECGE protein conformation 33410863 4 7 2 -Grm2 mGluR2 GPCR, family 3; Membrane protein, integral; Membrane protein, multi-pass; Receptor, GPCR P31421 24415 8q32 rat S843-p 450654 GSAAPRAsANLGQGS molecular association, regulation; activity, inhibited G-alpha 15(DISRUPTS) 10908604 1 0 0 -RIPK1 RIPK1 EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, Ser/Thr (non-receptor); Protein kinase, TKL Q13546 8737 6p25.2 human K627-ub 2188102 ERDGLKEkVYQMLQK Death protein degradation; ubiquitination; enzymatic activity, induced apoptosis, induced FADD(INDUCES); CASP8(INDUCES) 33311474; 35711363 4 4 0 Ripk1 K612R/K612R mice develop adult-onset intestinal in?ammation and splenomegaly, antibiotics rescues spontaneous gut in?ammation of RIPK1 K612R mutant mice; RDA (RIPK1 kinase dependent apoptosis) and necroptosis in response to TNFR1 signaling, p-IKKa/?, p-ERK1/2, p-JNK, and p-P38 were decreased in TNFa stimulated Ripk1K612R/K612R MEFs ; K627 localized in DD is a key ubiquitination site that can regulate the overall ubiquitination pattern of RIPK; cells stimulated by T/S and T/5Z-7; degradation and inhibited necroptosis; K627 in hRIPK1 is important for RIPK1 homodimerization -AFF1 AF-4 Oncoprotein; Transcription factor P51825 4299 4q21.3-q22.1 human K973-ac 1878271701 LHMREAKkMKQKAEL molecular association, regulation; intracellular localization transcription, inhibited MLLT3(DISRUPTS); CDK9(DISRUPTS); ELL(DISRUPTS) 31611376 1 0 0 Acetylation inhibits SEC component recruitment and is required for transcription inhibition and cell survival after exposure to genotoxic reagents. -DDX60 DDX60 EC 3.6.4.13; Hydrolase Q8IY21 55601 4q32.3 human Y793-p 2183531 PTSSGKTyASYYCME DEAD molecular association, regulation transcription, inhibited 25981042 1 1 0 reduced ATP binding, inhibited RIG-I-mediated IFN-beta promoter activation -Foxp1 FOXP1 C2H2-type zinc finger protein; Cell cycle regulation; DNA-binding; Transcription factor P58462 108655 6|6 D3 mouse S468-p 4164746 GPIRRRYsDKYNVPI intracellular localization 26171970 1 8 1 -NMT1 NMT1 EC 2.3.1.97; Motility/polarity/chemotaxis; Transferase P30419 4836 17q21.31 human Y180-p 10336300 YTLLNENyVEDDDNM NMT molecular association, regulation; enzymatic activity, induced LYN(INDUCES) 11594778 1 0 0 -SIRT3 SIRT3 DEACETYLASE; Deacetylase; EC 3.5.1.-; Mitochondrial Q9NTG7 23410 11p15.5 human S159-p 41655506 SGIPDFRsPGSGLYS SIR2 enzymatic activity, induced apoptosis, inhibited 26141949 1 0 0 -RRM2B RRM2B EC 1.17.4.1; Nucleotide Metabolism - purine; Nucleotide Metabolism - pyrimidine; Other Amino Acids Metabolism - glutathione; Oxidoreductase Q7LG56 50484 8q22.3 human S72-p 5014902 TAEEVDLsKDLPHWN Ribonuc_red_sm protein stabilization; ubiquitination cell cycle regulation 19015526 1 0 0 S72A-RRM2B mutant is hyperubiquitinated in UV-irradiated cells -Akap12 AKAP12 Adaptor/scaffold Q5QD51 83425 1q11 rat S507-p 469987 SPLKKLFsSSGLKKL molecular association, regulation cell cycle regulation CCNE1(DISRUPTS); CCND1(DISRUPTS) 10982843; 11820772 2 12 1 shown with PKC phosphorylated and nonphosphorylated AKAP12; in vivo permeable peptide/phosphopeptide experiments -GLI1 GLI1 C2H2-type zinc finger protein; Oncoprotein; Transcription factor P08151 2735 12q13.3 human R597-m2 59171800 RARYASArGGGTSPT molecular association, regulation carcinogenesis, induced; cell motility, induced; cell growth, induced; apoptosis, inhibited; transcription, induced DNA(INDUCES) 27758883 1 1 0 -Tmbim1 TMBIM1 Membrane protein, integral; Membrane protein, multi-pass Q8BJZ3 69660 1|1 C3 mouse K211-ub 1873041106 TIFCFQTkVDFTSCT Bax1-I molecular association, regulation Hrs(INDUCES) 28481357 1 1 0 -Polr2a POLR2A EC 2.7.7.48; EC 2.7.7.6; Nucleotide Metabolism - purine; Nucleotide Metabolism - pyrimidine; Transcription initiation complex; Transferase P08775 20020 11 B3|11 42.86 cM mouse K1859-ub 2134723 EYTPASPkYSPTSPK RNA_pol_Rpb1_R protein degradation 17526739 1 1 0 -Lef1 LEF-1 DNA-binding; Transcription factor P27782 16842 3 G3|3 60.78 cM mouse K267-sm 2535909 AIVTPQVkQEHPHTD intracellular localization; activity, inhibited transcription, inhibited 11731474 1 0 0 -TAGLN TAGLN Actin-binding; Motility/polarity/chemotaxis; Nuclear receptor co-regulator Q01995 6876 11q23.3 human K89-ub 1881229500 NPPSMVFkQMEQVAQ protein degradation; ubiquitination 33771884 1 0 0 -Mitf MITF iso8 DNA-binding; Oncoprotein; Transcription factor Q08874-8 17342 6 D3|6 45.05 cM mouse S73-p 450264 PGSSAPNsPMAMLTL MITF_TFEB_C_3_N molecular association, regulation transcription, inhibited PIAS3(INDUCES) 14645519 16 1 0 -FBXW7 FBXW7 Motility/polarity/chemotaxis; Nucleolus; UBIQUITIN LIGASE; Ubiquitin conjugating system; Ubiquitin ligase Q969H0 55294 4q31.3 human S26-p 482101 LRGNPSSsQVDEEQM intracellular localization 26774286 1 1 0 recruitment to DNA damage sites -GTF2I GTF2I iso2 DNA-binding; Transcription, coactivator/corepressor P78347-2 2969 7q11.23 human Y248-p 448250 EESEDPDyYQYNIQG molecular association, regulation cell cycle regulation; transcription, induced; transcription, altered ERK1(INDUCES) 11313464; 11373296; 11934902; 16314517 8 2 9 -Ppara PPAR-alpha DNA-binding; Nuclear receptor; UBIQUITIN LIGASE P37230 25747 7q34 rat T129-p 457548 CKGFFRRtIRLKLAY zf-C4 activity, induced; molecular association, regulation; intracellular localization transcription, induced; transcription, altered RXRA(INDUCES) DNA(INDUCES) 16042408; 22091731 2 0 0 -BACE1 BACE EC 3.4.23.46; Membrane protein, integral; Protease P56817 23621 11q23.3 human T252-p 48881800 YTGSLWYtPIRREWY Asp activity, induced 26317805 1 0 0 -BCKDK BCKDK EC 2.7.11.4; KINASE; Kinase, protein; Mitochondrial; Protein kinase, Ser/Thr (non-receptor); Protein kinase, atypical O14874 10295 16p11.2 human Y246-p 1868515109 RRLCEHKyGNAPRVR protein stabilization; ubiquitination; phosphorylation; enzymatic activity, induced carcinogenesis, induced; cell motility, induced 32238881 1 0 0 induces phosphorylation of MEK and BCKDHA, inhibits ubiquitination -H3-3A H3 DNA-binding Q5E9F8 326601 cow K36-m2 1458610 APSTGGVkKPHRYRP Histone cell cycle regulation; cell growth, inhibited; transcription, inhibited 16805913 44 18 7 -BECN1 beclin 1 Adaptor/scaffold; Autophagy; Membrane protein, peripheral Q14457 8678 17q21.31 human Y333-p 1874101912 QRYRLVPyGNHSYLE APG6 activity, induced; molecular association, regulation carcinogenesis, induced; autophagy, induced; cell growth, induced; apoptosis, inhibited rubicon(DISRUPTS); Bcl-2(DISRUPTS); PIK3R4(INDUCES); PIK3C3(INDUCES) 34131122 1 0 0 -Ptpn11 SHP-2 EC 3.1.3.48; Motility/polarity/chemotaxis; PHOSPHATASE; Protein phosphatase, tyrosine (non-receptor) P41499 25622 12q16 rat Y580-p 448493 REDSARVyENVGLMQ molecular association, regulation; phosphorylation caveolin-1(INDUCES) 25672415 18 60 1189 deletion SHP-2 SH2 domain reduces Src Y419 phosphorylation -Klf9 KLF9 C2H2-type zinc finger protein; DNA-binding Q01713 rat S110-p 241497503 SGSSPSHsPEERQDS molecular association, regulation cell motility, inhibited JNK3(INDUCES) 28871032 1 1 0 suppress neurite growth, KLF9 S106/110A mutants enhance optic nerve axon regeneration 2 weeks after optic nerve injury -E2F1 E2F1 DNA-binding; Transcription factor Q01094 1869 20q11.22 human T130-p 1870773101 GEKSRYEtSLNLTTK E2F_TDP protein degradation; enzymatic activity, induced cell cycle regulation; cell growth, inhibited; apoptosis, induced 33110360 1 0 0 induces ?-galactosidase activity -ZAP70 ZAP70 EC 2.7.10.2; KINASE; Kinase, protein; Protein kinase, TK; Protein kinase, tyrosine (non-receptor) P43403 7535 2q11.2 human K544-ub 55588401 QKPYKKMkGPEVMAF PK_Tyr_Ser-Thr molecular association, regulation; enzymatic activity, inhibited; phosphorylation cell differentiation, inhibited; transcription, inhibited; signaling pathway regulation STS-1(INDUCES); STS2(INDUCES) 26903241 1 2 0 regulates TCR signaling, inhibits phosphorylation of itself and downstream targets -IL22RA1 IL22RA1 Membrane protein, integral Q8N6P7 58985 1p36.11 human Y251-p 15512803 AVLCYLSyRYVTKPP molecular association, regulation SHP-2(INDUCES) 20671117 1 0 0 necessary for IL22RA1 to mediate the IL-22-stimulated MAP kinases and STAT3 activation -SLC9A1 NHE1 Membrane protein, integral; Membrane protein, multi-pass; Motility/polarity/chemotaxis; Transporter; Transporter, SLC family P19634 6548 1p36.11 human T653-p 4729330 LRSYNRHtLVADPYE NEXCaM_BD activity, induced cell motility, induced; cytoskeletal reorganization; cell growth, altered 25578862; 27555478 2 2 2 stress fiber formation, in S703A and T653A mutants proliferation was substantially higher -PRKCA PKCA EC 2.7.11.13; KINASE; Kinase, protein; Oncoprotein; Protein kinase, AGC; Protein kinase, Ser/Thr (non-receptor) P17252 5578 17q24.2 human S226-p 2050181 LNPQWNEsFTFKLKP C2 molecular association, regulation; enzymatic activity, induced RhoGDI beta(INDUCES) 26414765 1 44 42 -IDH1 IDH1 Carbohydrate Metabolism - citrate (TCA) cycle; EC 1.1.1.42; Other Amino Acids Metabolism - glutathione; Oxidoreductase O75874 3417 2q34 human Y42-p 3563660 VELDLHSyDLGIENR Iso_dh molecular association, regulation IDH1(INDUCES) 30862724 1 2 2 -KANSL3 KANSL3 iso3 Unknown function Q9P2N6-3 55683 2q11.2 human T755-gl 1879982200 PGPAPQAtSVKLPTP protein stabilization 31881804 1 1 0 H4 K5, K8, and K16 levels increased by T755-gl stabilization -TBC1D4 AS160 GAP; GAP, Rab O60343 9882 13q22.2 human S318-p 455925 EFRSRCSsVTGVQRR PID molecular association, regulation endocytosis, induced; signaling pathway regulation 14-3-3 epsilon(INDUCES) 20410134; 26465605 13 18 334 albumin endocytosis; multiple sites (6P) mutant -Tfe3 TFE3 DNA-binding; Oncoprotein; Transcription factor Q64092 209446 X A1.1|X 3.5 cM mouse S320-p 53350801 PAITVSNsCPAELPN intracellular localization; activity, inhibited transcription, inhibited 27913603; 35358174 5 1 0 -GLI1 GLI1 C2H2-type zinc finger protein; Oncoprotein; Transcription factor P08151 2735 12q13.3 human S1089-p 1873647706 NMAVGNMsVLLRSLP protein stabilization; molecular association, regulation; intracellular localization carcinogenesis, induced; cell growth, induced; transcription, induced SUFU(DISRUPTS) 34052323 1 1 0 -GAB1 GAB1 Adaptor/scaffold; Motility/polarity/chemotaxis Q13480 2549 4q31.21 human Y242-p 455030 FFQQQMIyDSPPSRA molecular association, regulation CDK6(INDUCES) 19881549 2 8 269 promotes HGF-induced DNA synthesis -PDE4D PDE4D iso6 EC 3.1.4.53; Nucleotide Metabolism - purine; Phosphodiesterase Q08499-6 5144 5q11.2-q12.1 human K53-ub 7388019 ARKSVSPkLSPVISP molecular association, regulation RACK1(DISRUPTS); ARRB1(INDUCES) 19372219 1 0 0 -GABARAPL2 GABARAPL2 Adaptor/scaffold; Autophagy; Microtubule-binding; Ubiquitin-like modifier; Vesicle P60520 11345 16q23.1 human S88-p 1869546302 DKTVPQSsLTMGQLY ATG8 molecular association, regulation apoptosis, induced ATG4B(DISRUPTS) 31709703 1 1 0 ; including ATG4A, ATG4C, ATG4D -DLGAP1 SAPAP1 iso2 Cytoskeletal O14490-2 9229 18p11.31 human S393-p 4775408 RRFTRSNsVTTAVQA GKAP molecular association, regulation; intracellular localization neural plasticity DLC1(DISRUPTS) 23143515 1 0 0 -HNRNPK hnRNP K RNA splicing; RNA-binding; Spliceosome P61978 3190 9q21.32 human Y234-p 456002 PNFYDETyDYGGFTM translation, altered 12052863 1 1 0 based on Y72/225/230/234/236/380A mutant -Etv4 ETV4 DNA-binding P28322 18612 11 D|11 65.48 cM mouse K261-ac 26373301 PGAGVVIkQERTDFA ETS_PEA3_N sumoylation transcription, induced 21543453 1 1 0 acetylated sites inhibits sumoylation reciprocally -BRCA1 BRCA1 EC 6.3.2.-; Nuclear receptor co-regulator; Transcription, coactivator/corepressor; Tumor suppressor; UBIQUITIN LIGASE; Ubiquitin conjugating system; Ubiquitin ligase P38398 672 17q21.31 human Y1552-p 50684000 HDLTETSyLPRQDLE protein stabilization 29156836 1 1 0 -CFTR CFTR Channel, chloride; EC 3.6.3.49; Hydrolase; Membrane protein, integral; Membrane protein, multi-pass; Transporter; Transporter, ABC family P13569 1080 7q31.2 human T582-p 2907507 FGYLDVLtEKEIFES activity, induced 12588899; 14695900 2 0 0 -PPP1R12A MYPT1 Motility/polarity/chemotaxis; PHOSPHATASE; Protein phosphatase, regulatory subunit O14974 4659 12q21.2-q21.31 human S507-p 477839 TIPRRLAsTSDIEEK cytoskeletal reorganization 37064875 2 51 789 -FHOD1 FHOD1 Actin-binding Q9Y613 29109 16q22.1 human S1137-p 2035403 RSRGNRKsLRRTLKS activity, induced cytoskeletal reorganization; cell growth, altered FHOD1(DISRUPTS) 18239683; 21106951 2 1 10 autoinhibitory interaction between C- and N-terminal part of FHOD1 is attenuated in S1130D/S1136D/T1140D triple mutant -Ltb4r LTB4R GPCR, family 1; Membrane protein, integral; Membrane protein, multi-pass; Receptor, GPCR O88855 16995 14 C3|14 28.19 cM mouse S127-p 2862101 AVARPFMsQKVRTKA 7tm_1 receptor desensitization, altered 17595524 1 0 0 -Marcks MARCKS Actin-binding; Motility/polarity/chemotaxis P26645 17118 10 B1|10 19.49 cM mouse S160-p 466360 FKKSFKLsGFSFKKS MARCKS intracellular localization carcinogenesis, induced; cell motility, altered 20211725 7 44 11 -Alyref2 Refbp2 DNA-binding; RNA-binding Q9JJW6 56009 1|1 H3 mouse R181-m2 13906406 GSGGFGGrGSQGRGR FoP_duplication molecular association, regulation RNA(DISRUPTS) 20129943 1 1 0 -PCK1 PCK1 Carbohydrate Metabolism - citrate (TCA) cycle; Carbohydrate Metabolism - glycolysis and gluconeogenesis; Carbohydrate Metabolism - pyruvate; EC 4.1.1.32; KINASE; Kinase, other; Lyase; Protein kinase, Ser/Thr (non-receptor) P35558 5105 20q13.31 human S90-p 1868515110 RDVARIEsKTVIVTQ PEPCK_N protein degradation; acetylation; ubiquitination; intracellular localization; protein conformation; activity, inhibited carcinogenesis, induced 30193097; 32322062; 33842305 3 1 0 -CSF3R GCSFR Membrane protein, integral; Receptor, cytokine Q99062 1441 1p34.3 human K695-ub 9381805 LGTPPITkLTVLEED receptor internalization, induced; protein degradation; intracellular localization; phosphorylation cell growth, inhibited; signaling pathway regulation 19453968 1 0 0 regulates production of neutrophilic granulocytes, regulates STAT5 activation -CSNK1E CK1E EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, CK1; Protein kinase, Ser/Thr (non-receptor) P49674 1454 22q13.1 human S323-p 453416 RMGQLRGsATRALPP enzymatic activity, inhibited 10542239; 12223474 2 4 1 some subset of these 8 sites -Anxa2 ANXA2 Calcium-binding; Lipid-binding; Motility/polarity/chemotaxis Q07936 56611 8q24 rat S26-p 450879 TPPSAYGsVKPYTNF translation, inhibited 34346292 14 29 100 -RECQL4 RECQL4 EC 3.6.4.12; Helicase O94761 9401 8q24.3 human K376-ac 7106307 LRSRLLRkQAWKQKW intracellular localization 19299466 1 0 0 accumulates in the cytoplasm -PDE4B PDE4B EC 3.1.4.53; Nucleotide Metabolism - purine; Phosphodiesterase Q07343 5142 1p31.3 human S659-p 471380 YQSMIPQsPSPPLDE enzymatic activity, inhibited 11030732 1 5 0 increases levels of cAMP -Gja1 GJA1 Channel, misc.; Membrane protein, integral; Membrane protein, multi-pass; Motility/polarity/chemotaxis P08050 24392 20q11 rat S325-p 449992 NRMGQAGsTISNSHA Connexin43 intracellular localization cell adhesion, induced; cell adhesion, altered; signaling pathway regulation 12270943; 23742896 10 14 0 cardiomyocyte FGF signaling, maintenance of cell-cell gap junctions -DLGAP1 SAPAP1 iso2 Cytoskeletal O14490-2 9229 18p11.31 human S349-p 2049913 FKKNRCLsIGIQVDD GKAP molecular association, regulation; intracellular localization neural plasticity DLC1(DISRUPTS) 23143515 1 3 0 -ING3 ING3 Transcription, coactivator/corepressor Q9NXR8 54556 7q31.31 human K96-ub 11489912 LVDRHLRkLDQELAK ING protein degradation; molecular association, regulation cell cycle regulation; carcinogenesis, induced; apoptosis, inhibited SKP2(INDUCES) 19935701 1 0 0 -CD6 CD6 Cell surface; Membrane protein, integral P30203 923 11q12.2 human Y662-p 450239 DSTDNDDyDDISAA_ activity, induced; molecular association, regulation SLP76(INDUCES); GADS(INDUCES) 28289074 2 1 0 -GMFG GMF-gamma Actin-binding O60234 9535 19q13.2 human S2-p 467229 ______MsDSLVVCE molecular association, regulation cytoskeletal reorganization ARPC3(INDUCES); ACTA1(INDUCES) 16873721 1 1 0 phosphorylation of this site enhances binding of GMFG to F-actin and reduces the interaction between F-actin and cofilin -Dlg4 PSD-95 Adaptor/scaffold P31016 29495 10q24 rat Y397-p 473889 AQYKPEEySRFEAKI protein conformation CRIPT(DISRUPTS) 21965656 3 1 6 Y397E mutant showed dissociation, triple mutant Y397E/S415E/S418E showed stronger dissociation -SLBP SLBP RNA-binding Q14493 7884 4p16.3 human T62-p 466352 RRPESFTtPEGPKPR protein degradation; molecular association, regulation; phosphorylation apoptosis, inhibited CUL4A(INDUCES); WDR23(INDUCES) 12588979; 18490441; 27254819 4 6 8 degradation is essential for the viability of cells -HTR6 5-HT(6) GPCR, family 1; Membrane protein, integral; Membrane protein, multi-pass; Receptor, GPCR P50406 3362 1p36.13 human S350-p 1867750504 ERQASLAsPSLRTSH molecular association, regulation; activity, inhibited; enzymatic activity, induced cell growth, induced GRIN1(DISRUPTS) 32047117 1 0 0 induces Cdc42 activity further enhancing neurite growth -H4c2 H4 DNA-binding P62806 326620 13|13 A3.1 mouse K12-ac 459013 KGGKGLGkGGAKRHR cell cycle regulation; chromatin organization, altered; apoptosis, induced; transcription, induced; transcription, altered; transcription, inhibited 17344422; 17530637; 17626110; 17823087; 19641176; 19965984; 20448184; 20710121 93 25 531 may be associated with gene expression -Slc12a3 NCCT Membrane protein, integral; Membrane protein, multi-pass; Transporter; Transporter, SLC family P59158 20497 8 C5|8 46.46 cM mouse T58-p 469617 MRTFGYNtIDVVPAY AA_permease_N activity, induced; protein stabilization; ubiquitination; intracellular localization; phosphorylation 20962898; 22846565; 23833262; 34174287 25 3 0 -ERBB2 HER2 EC 2.7.10.1; KINASE; Kinase, protein; Membrane protein, integral; Oncoprotein; Protein kinase, TK; Protein kinase, tyrosine (receptor) P04626 2064 17q12 human Y1222-p 448675 PAFDNLYyWDQDPPE molecular association, regulation; enzymatic activity, induced carcinogenesis, induced; apoptosis, inhibited; cell motility, altered; transcription, induced; signaling pathway regulation; cell growth, altered GRB2(INDUCES); MEMO1(INDUCES); SHC1(INDUCES) 11238891; 15156151; 16729043; 18332126; 19525980; 20498373; 21840311; 37324940 36 1 8 -Bub1b BUB1B EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, Other; Protein kinase, Ser/Thr (non-receptor); Tumor suppressor Q9Z1S0 12236 2|2 E5 mouse S665-p 767909 LSPIIEEsREATHSS phosphorylation 26028219 9 4 0 decrease CASC5 phosphorylation -IRF1 IRF1 Transcription factor; Tumor suppressor P10914 3659 5q31.1 human Y109-p 2299205 GSSAVRVyRMLPPLT IRF transcription, altered 11483597 1 0 0 -BIK BIK Apoptosis; Membrane protein, integral; Mitochondrial Q13323 638 22q13.2 human K115-ub 21129908 MDGFTTLkENIMRFW bcl-2I13 protein degradation; ubiquitination apoptosis, inhibited 31387940 1 3 0 IRE1alpha?XBP1 axis prevents premature apoptosis allows time for cell adaptation to ER stress -MAZ MAZ C2H2-type zinc finger protein; RNA-binding; Transcription factor O97600 100008693 rabbit T386-p 449095 KDRLRAHtVRHEEKV activity, induced; protein conformation transcription, induced DNA(INDUCES) 12697757 2 0 0 -GFPT1 GFAT iso2 Amino Acid Metabolism - alanine, aspartate and glutamate; Carbohydrate Metabolism - amino sugar and nucleotide sugar; EC 2.6.1.16; Transferase Q06210-2 2673 2p13.3 human S243-p 467935 CNLSRVDsTTCLFPV O-GlcNAc glycosylation; enzymatic activity, inhibited cell differentiation, induced 19170765; 28008135 4 83 522 promotes angiogenesis -YAP1 YAP1 Oncoprotein; Transcription, coactivator/corepressor P46937 10413 11q22.1 human S217-p 33668511 MNVTAPTsPPVQQNM molecular association, regulation apoptosis, inhibited TEAD4(DISRUPTS) 24812269 1 0 0 -Eif4b EIF4B RNA-binding; Translation; Translation initiation Q8BGD9 75705 15|15 F2 mouse S406-p 470374 RPRERHPsWRSEETQ translation, altered 18836482 8 50 670 -Top1 TOP1 EC 5.99.1.2; Isomerase; Nucleolus; Oncoprotein Q04750 21969 2 H2|2 80.96 cM mouse Y270-p 454026 AKMLDHEyTTKEIFR Topoisom_I_N enzymatic activity, induced 15448168 1 2 1 phosphorylation of this site stimulates the TOP1 isomerase function -Src Src EC 2.7.10.2; KINASE; Kinase, protein; Oncoprotein; Protein kinase, TK; Protein kinase, tyrosine (non-receptor) P05480 20779 2 H1|2 78.35 cM mouse S74-p 450326 NSSDTVTsPQRAGPL cell differentiation, induced; transcription, induced 33798451 9 24 3 -POLL POLL DNA repair, damage; EC 2.7.7.7; Lyase; Transferase Q9UGP5 27343 10q24.32 human T204-p 62925702 EASDGEEtQVSAADL molecular association, regulation DNA repair, induced Ku80(INDUCES) 28109743 1 0 0 -RELA NFkB-p65 DNA-binding; Nuclear receptor co-regulator; Transcription factor Q04206 5970 11q13.1 human T305-p 10800660 IEEKRKRtYETFKSI transcription, inhibited 28416608 1 1 1 impaired acetylation of p65 at K310 -LIPE HSL EC 3.1.1.79; Lipase Q05469 3991 19q13.2 human S951-p 450195 GFHPRRSsQGATQMP Abhydrolase_3 molecular association, regulation; enzymatic activity, induced FABP4(INDUCES) 17785468; 19018281 29 14 16 -DRD1 DRD1 GPCR, family 1; Membrane protein, integral; Membrane protein, multi-pass; Receptor, GPCR P21728 1812 5q35.2 human T439-p 1869357201 LEKIQPItQNGQHPT molecular association, regulation signaling pathway regulation G-alpha(s)(INDUCES); ARR3(INDUCES) 32503917 1 0 0 ERK1/2 activation -VAV2 VAV2 GEF; GEF, Rac/Rho; Motility/polarity/chemotaxis P52735 7410 9q34.2 human Y172-p 452202 EDGGDDIyEDIIKVE activity, induced; molecular association, regulation cell growth, induced; cell adhesion, induced MST3(INDUCES) 25386896; 26910843 3 0 3 increased VAV2 Y172 phosphorylation -FGFR3 FGFR3 EC 2.7.10.1; KINASE; Kinase, protein; Membrane protein, integral; Protein kinase, TK; Protein kinase, tyrosine (receptor) P22607 2261 4p16.3 human Y724-p 448116 ANCTHDLyMIMRECW PK_Tyr_Ser-Thr molecular association, regulation; phosphorylation; enzymatic activity, induced transcription, altered; cell growth, altered SH2-B-beta(INDUCES) 11294897; 11827956 2 1 2 stimulates phosphorylation of Shp2, MAPK, Stat1 and Stat3, activates PI3K; stimulates the transforming activity of FGFR3 -XPA XPA DNA repair, damage P23025 7507 9q22.33 human S196-p 460698 RSLEVWGsQEALEEA protein stabilization; molecular association, regulation DNA repair, induced; apoptosis, altered H2AX(INDUCES); HERC2(DISRUPTS); RPA1(INDUCES) DNA(INDUCES) 16540648; 23178497; 35216341 6 3 0 -Nefl NFL Cytoskeletal P08551 18039 14|14 D1 mouse S56-p 451024 SSLSVRRsYSSSSGS Filament_head molecular association, regulation; intracellular localization 14-3-3 gamma(INDUCES) 23230147 9 3 1 regulates NF-L dynamic exchange rate and neurofilament disassembly -H4C1 H4 DNA-binding P62805 8359 6p22.2 human K20-m2 465128 GGAKRHRkVLRDNIQ CENP-T_C acetylation; molecular association, regulation; intracellular localization cell cycle regulation; DNA repair, induced; transcription, inhibited FANCD2(INDUCES); 53BP1(DISRUPTS); MBTD1(INDUCES); JMJD2A(INDUCES); CRB2(INDUCES); 53BP1(INDUCES) 17190600; 17967882; 18470998; 19706462; 23329852; 27153538; 31085681; 31911551; 33188174 30 16 1 HBD/MBD is required for ef?cient chromatin binding and nuclear focus formation; MBTD1 can displace 53BP1 from the H4K20me2 histone mark -CRK CRK Adaptor/scaffold; Motility/polarity/chemotaxis; Oncoprotein P46108 1398 17p13.3 human S41-p 454189 VFLVRDSsTSPGDYV SH2 carcinogenesis, induced; cell motility, induced; transcription, inhibited 22848689 2 18 17 -Dag1 DAG1 Cytoskeletal; Membrane protein, integral; Motility/polarity/chemotaxis Q62165 13138 9 F1|9 59.08 cM mouse Y890-p 449630 PYRSPPPyVPP____ DAG1 receptor internalization, induced; protein degradation; molecular association, regulation; intracellular localization cytoskeletal reorganization Tks5(INDUCES) 12795607; 18982058; 22810924; 28591567; 28852008 8 2 19 -KCNJ10 Kir4.1 Channel, ligand-gated; Channel, potassium; Membrane protein, integral; Membrane protein, multi-pass P78508 3766 1q23.2 human Y9-p 3477640 TSVAKVYySQTTQTE activity, induced 23873931 1 1 4 induce whole cell K current, and may regulate channel number in plasma membrane -SFN 14-3-3 sigma Adaptor/scaffold P31947 2810 1p36.11 human S186-p 456054 FHYEIANsPEEAISL 14-3-3 molecular association, regulation; phosphorylation apoptosis, induced CBY1(DISRUPTS); JNK1(INDUCES); BAX(DISRUPTS) 15071501; 16009721; 26147002 5 0 0 -PTEN PTEN Carbohydrate Metabolism - inositol phosphate; EC 3.1.3.16; EC 3.1.3.48; EC 3.1.3.67; Motility/polarity/chemotaxis; Nuclear receptor co-regulator; PHOSPHATASE; Phosphatase, lipid; Tumor suppressor P60484 5728 10q23.31 human S229-p 456213 VKIYSSNsGPTRRED PTEN_C2 cell motility, altered 15793569 1 1 1 -ESR2 ER-beta DNA-binding; Nuclear receptor Q92731 2100 14q23.2-q23.3 human S200-p 23068601 IDKNRRKsCQACRLR zf-C4 molecular association, regulation DNA(DISRUPTS) 34147032 2 1 0 -Nr3c1 GR DNA-binding; Mitochondrial; Nuclear receptor; Transcription factor P06537 14815 18 B3|18 21.09 cM mouse K310-sm 2532300 LCTPGVIkQEKLGPV GCR transcription, inhibited 26712002 7 3 0 -TGFBR2 TGFBR2 EC 2.7.11.30; KINASE; Kinase, protein; Membrane protein, integral; Oncoprotein; Protein kinase, Ser/Thr (receptor); Protein kinase, TKL P37173 7048 3p24.1 human K567-ne 27581513 DGSLNTTk_______ protein stabilization; ubiquitination 23290524 1 0 0 antagonizes its ubiquitination -Myh9 MYH9 Actin-binding; Motility/polarity/chemotaxis; Motor Q8VDD5 17886 15 E1|15 36.81 cM mouse S1943-p 456730 RKGTGDCsDEEVDGK cell motility, induced; cytoskeletal reorganization; cell motility, inhibited 22025714; 32315395 14 118 916 -PTH1R PTHR GPCR, family 2; Membrane protein, integral; Membrane protein, multi-pass; Receptor, GPCR Q03431 5745 3p21.31 human Y494-p 28764913 ARSGSSSySYGPMVS intracellular localization cell differentiation, induced; cytoskeletal reorganization 29507819 1 2 0 length of dendrites was decreased in Y494F cells; Y-PTH1R localizes to dendrites during osteoblast-to-osteocyte differentiation in vivo; Y494-phosphorylation site speci?cally contributed to polymerization of actin ?laments -IGFBP1 IGFBP1 Secreted; Secreted, signal peptide P08833 3484 7p12.3 human S199-p 51637400 ETSGEEIsKFYLPNC Thyroglobulin_1 molecular association, regulation; activity, inhibited signaling pathway regulation CK2B(INDUCES) 32502935 4 4 0 regulates mTOR and AAR signaling -RAD54L RAD54L Cell cycle regulation; DNA repair, damage; EC 3.6.1.-; EC 3.6.4.-; Helicase Q92698 8438 1p34.1 human S49-p 31855101 QIQECFLsPFRKPLS protein conformation DNA repair, inhibited DNA(DISRUPTS) 29295984 1 3 0 impairs DNA-dependent RAD54 oligomerization and inhibits RAD54 branch migration (BM) activity -ETV6 Tel DNA-binding; Motility/polarity/chemotaxis; Oncoprotein; Transcription factor P41212 2120 12p13.2 human S257-p 451378 ESHPKPSsPRQESTR molecular association, regulation; intracellular localization; activity, inhibited cell differentiation, altered; transcription, induced; transcription, inhibited; cell growth, altered DNA(DISRUPTS) 15060146; 18022807 3 2 0 -Nos1 nNOS Amino Acid Metabolism - arginine and proline; EC 1.14.13.39; Oxidoreductase P29476 24598 12q16 rat K38-ac 2459105 LVKERVSkPPVIISD PDZ activity, induced 18415985 1 1 0 -NBN NBS1 Cell cycle regulation; DNA repair, damage O60934 4683 8q21.3 human K334-ac 487509 GHPSTGLkTTTPGPS phosphorylation cell cycle regulation; apoptosis, induced 17612497 2 1 0 inhibits phosphorylation at S343 -PIAS1 PIAS1 EC 6.3.2.-; Nuclear receptor co-regulator; SUMO LIGASE; SUMO conjugating system; SUMO ligase; Transcription, coactivator/corepressor O75925 8554 15q23 human S467-p 4700788 IDLTIDSsSDEEEEE molecular association, regulation transcription, inhibited SUMO2(INDUCES); SUMO1(INDUCES); UBC9(INDUCES) 19217413; 24174529 2 8 0 -XRCC5 Ku80 DNA-binding; EC 3.6.1.-; EC 3.6.4.-; Helicase; Nuclear receptor co-regulator; Nucleolus; RNA-binding P13010 7520 2q35 human K465-ub 12344137 IDSMSLAkKDEKTDT molecular association, regulation DNA repair, induced DNA(DISRUPTS) 27895153 1 1 2 -RPL11 RPL11 Motility/polarity/chemotaxis; Nucleolus; Ribosomal; Translation P62913 6135 1p36.11 human K178-ne 12067613 DGIILPGk_______ protein stabilization; intracellular localization 19713960 1 0 0 -Cadps CADPS Vesicle Q62717 26989 15p15 rat S6-p 7712500 __MLDPSsSEEESDE activity, induced exocytosis, altered 19460754 1 2 0 -SP1 SP1 C2H2-type zinc finger protein; DNA-binding; Transcription factor P08047 6667 12q13.13 human S101-p 767911 DLTATQLsQGANGWQ sumoylation; protein degradation; molecular association, regulation; protein stabilization; ubiquitination; intracellular localization DNA repair, induced; DNA repair, altered RNF4(INDUCES) 18619531; 22826432; 25355892; 35124373 6 0 0 induces sumoylation -BTRC BTRC Motility/polarity/chemotaxis; UBIQUITIN LIGASE; Ubiquitin conjugating system; Ubiquitin ligase Q9Y297 8945 10q24.32 human S82-p 1869876000 SLRQTYNsCARLCLN protein degradation; ubiquitination signaling pathway regulation 31406304 1 0 0 -IRF7 IRF7 DNA-binding; Transcription factor Q92985 3665 11p15.5 human K375-ub 573779820 ARRMGKCkVYWEVGG IRF-3 transcription, induced 35792897 1 2 0 increased levels of H3K27ac on IRF7 binding regions -Plekho1 PLEKHO1 Adaptor/scaffold; Tumor suppressor Q9JIY0 67220 3|3 F2.1 mouse S341-p 12739074 KAKDPPQsPPDSESE protein degradation; ubiquitination 24777252 1 4 0 -Grm7 mGluR7 GPCR, family 3; Membrane protein, integral; Membrane protein, multi-pass; Receptor, GPCR P35400 81672 4q41 rat S862-p 2846504 NVQKRKRsFKAVVTA molecular association, regulation; receptor internalization, inhibited endocytosis, inhibited Calmodulin(DISRUPTS) 12021391; 23612982 4 0 0 -Gja1 GJA1 Channel, misc.; Membrane protein, integral; Membrane protein, multi-pass; Motility/polarity/chemotaxis P23242 14609 10 B4|10 28.64 cM mouse S365-p 459207 IVDQRPSsRASSRAS intracellular localization; protein conformation 17714073; 29269353 15 15 2 -Ngef ephexin-1 GEF; GEF, Rac/Rho Q8CHT1 53972 1 D|1 44.42 cM mouse Y177-p 455579 IEQIGLLyQEYRDKS activity, induced cell motility, altered; cytoskeletal reorganization 15848799 4 0 2 -Tgfbr2 TGFBR2 iso1 EC 2.7.11.30; KINASE; Kinase, protein; Membrane protein, integral; Oncoprotein; Protein kinase, Ser/Thr (receptor); Protein kinase, TKL Q62312-1 21813 9 F3|9 68.39 cM mouse Y309-p 479864 KIFPYEEySSWKTEK PK_Tyr_Ser-Thr cytoskeletal reorganization; cell growth, altered 18174260 3 0 0 important for TGF beta -induced cell invasion -MET Met EC 2.7.10.1; KINASE; Kinase, protein; Membrane protein, integral; Oncoprotein; Protein kinase, TK; Protein kinase, tyrosine (receptor) P08581 4233 7q31.2 human Y1349-p 448472 STFIGEHyVHVNATY activity, induced; molecular association, regulation; enzymatic activity, induced carcinogenesis, induced; cell motility, induced; cell growth, induced; cell motility, altered; signaling pathway regulation; cell growth, altered GRB2(INDUCES); Src(INDUCES); PLCG1(INDUCES); Ron(INDUCES); GAB1(INDUCES); Met(INDUCES); SHC1(INDUCES); FAK(INDUCES); PIK3R1(INDUCES) 10490849; 10506185; 10871856; 12766170; 16782899; 21777671; 24634221; 27401557; 7513258; 7687741; 7731718; 8906793; 9391119; 9826708 30 6 125 -Pxn PXN Adaptor/scaffold; Cell adhesion; Cytoskeletal; Motility/polarity/chemotaxis Q8VI36 19303 5 F|5 56.1 cM mouse Y40-p 449965 YPTGNHTyQEIAVPP apoptosis, inhibited 30604146 3 3 28 -MYB Myb DNA-binding; Oncoprotein; Transcription factor P10242 4602 6q23.3 human S12-p 448187 PRHSIYSsDEDDEDF molecular association, regulation transcription, altered DNA(DISRUPTS) 7735324 5 1 2 -NCOA1 SRC-1 ACETYLTRANSFERASE; Acetyltransferase; DNA-binding; EC 2.3.1.48; Nuclear receptor co-regulator; Oncoprotein; Transcription, coactivator/corepressor Q15788 8648 2p23.3 human T1179-p 449063 NYGTNPGtPPASTSP DUF1518 transcription, altered 11073973; 12163482 4 0 0 -Tbk1 TBK1 EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, Other; Protein kinase, Ser/Thr (non-receptor) Q9WUN2 56480 10|10 D2 mouse S172-p 447732 EDDEQFVsLYGTEEY Pkinase intracellular localization; phosphorylation; enzymatic activity, induced carcinogenesis, induced; carcinogenesis, inhibited; cell growth, inhibited; transcription, induced; transcription, altered; signaling pathway regulation; autophagy, induced; cell differentiation, induced; apoptosis, inhibited 33510463; 33941660; 34145038; 34161773; 34233950; 34245780; 34433039; 34910106; 35613599; 36008706; 36113429 76 8 47 -IKZF1 Ikaros C2H2-type zinc finger protein; DNA-binding; Transcription factor Q13422 10320 7p12.2 human S393-p 451351 REASPSNsCQDSTDT cell cycle regulation; cell growth, induced 27026320 2 1 3 -RHOT1 RHOT1 EC 3.6.5.-; G protein; G protein, monomeric; G protein, monomeric, Rho; Hydrolase; Membrane protein, integral; Mitochondrial Q8IXI2 55288 17q11.2 human K182-ub 12255120 CPEEKEMkPACIKAL protein degradation; intracellular localization autophagy, induced 34152608 1 1 1 induces mitophagy by recruiting Parkin to mitochondria -NUP62 NUP62 Adaptor/scaffold; Nucleoporin P37198 23636 19q13.33 human T269-p 36440512 GAASGTStTTSTAAT protein degradation; phosphorylation signaling pathway regulation 30401435 1 0 0 induces phosphorylation of IRS1, regulates p38?/p62/mTORC1 pathway -SMAD4 SMAD4 DNA-binding; Nuclear receptor co-regulator; Transcription, coactivator/corepressor Q13485 4089 18q21.2 human T77-p 17478300 KCVTIQRtLDGRLQV MH1 molecular association, regulation transcription, altered DNA(DISRUPTS) 20974850 1 0 0 negatively regulates TGFbeta signaling -GRIA2 GluR2 Channel, calcium; Channel, ligand-gated; Membrane protein, integral; Membrane protein, multi-pass P42262 2891 4q32.1 human Y876-p 452173 YKEGYNVyGIESVKI molecular association, regulation neural plasticity GRIP1(DISRUPTS) 26109571; 32071234 9 5 109 -HDGF HDGF Cytokine; Transcription regulation P51858 3068 1q23.1 human K80-sm 3278903 FGKPNKRkGFSEGLW PWWP molecular association, regulation DNA(DISRUPTS) 18331345 1 3 0 -Rin1 Rin1 GEF; GEF, Rab Q921Q7 225870 19|19 A mouse Y120-p 2796501 PSFVSSHyIEESTGG molecular association, regulation Arg(INDUCES) 15886098 1 0 0 -KCNQ1 Kv7.1 Channel, potassium; Membrane protein, integral; Membrane protein, multi-pass P51787 3784 11p15.5-p15.4 human S409-p 456162 SHTLLSPsPKPKKSV activity, induced 12879210 1 3 0 -PTEN PTEN Carbohydrate Metabolism - inositol phosphate; EC 3.1.3.16; EC 3.1.3.48; EC 3.1.3.67; Motility/polarity/chemotaxis; Nuclear receptor co-regulator; PHOSPHATASE; Phosphatase, lipid; Tumor suppressor P60484 5728 10q23.31 human Y174-p 464091 TIPSQRRyVYYYSYL activity, inhibited 23995781 2 4 10 PTEN downregulation -IKZF1 Ikaros C2H2-type zinc finger protein; DNA-binding; Transcription factor Q13422 10320 7p12.2 human S361-p 14160239 LAEGTPRsNHSAQDS molecular association, regulation; intracellular localization cell differentiation, induced; transcription, induced DNA(INDUCES) 23071339 1 6 0 induces transcription of DNAJC6, EIF4e3, TNFAIP8L2; nuclear localization -DLC1 DLC1 GAP; GAP, Rac/Rho; Tumor suppressor Q96QB1 10395 8p22 human S642-p 37038504 DSFGSLPsPKELSSF activity, induced; intracellular localization; protein conformation carcinogenesis, inhibited; cell growth, inhibited; cell motility, inhibited talin 1(INDUCES); tensin 1 iso1(INDUCES) 25452387 1 3 0 localize to focal adhesions; activates Rho-GAP activity -Kcnj3 GIRK1 Channel, potassium; Membrane protein, integral; Membrane protein, multi-pass P63251 50599 3q21 rat Y67-p 3146602 LGSETSRyLSDLFTT IRK activity, inhibited 10833508 1 1 0 -Inpp5d SHIP EC 3.1.3.86; Motility/polarity/chemotaxis; Phosphatase, lipid Q9ES52 16331 1 D|1 44.44 cM mouse Y918-p 450030 NEMINPNyIGMGPFG molecular association, regulation SHC1(INDUCES); DOK1(INDUCES) 11031258; 9099679 3 9 175 -IP6K2 IHPK2 EC 2.7.4.21; Kinase, other; Motility/polarity/chemotaxis Q9UHH9 51447 3p21.31 human S359-p 478423 LEDLSEEsADESAGA IPK apoptosis, induced; cell growth, altered TRAF2(INDUCES) DNA(INDUCES) 17379600 1 1 0 induces NFkB-DNA binding -KLF13 KLF13 C2H2-type zinc finger protein; DNA-binding Q9Y2Y9 51621 15q13.3 human S123-p 40721822 APPSPAWsEPEPEAG protein degradation; ubiquitination 37029927 1 1 0 -MACF1 ACF7 Actin-binding; Cytoskeletal; Motility/polarity/chemotaxis Q9UPN3 23499 1p34.3 human S7222-p 18507012 FRSRGRRsKPSSRAA intracellular localization cell motility, induced; cytoskeletal reorganization 21295697 1 1 0 inhibits localization along microtubules, alters organization of microtubules, regulates skin wound repair, SC migration -DNM1L DRP1 Apoptosis; EC 3.6.5.5; Endoplasmic reticulum; Hydrolase; Microtubule-binding; Mitochondrial; Motor O00429 10059 12p11.21 human K594-sm 9859923 GNWRGMLkTSKAEEL activity, induced; intracellular localization 19638400 1 0 0 sumoylation is linked to its GTPase activity cycle, and influenced by DRP1 localization -RUNX1 AML1 iso8 DNA-binding; Oncoprotein; Transcription factor Q01196-8 861 21q22.12 human S276-p 454399 DTRQIQPsPPWSYDQ protein degradation; phosphorylation cell differentiation, induced 16046550; 17015473; 22531928 10 8 46 -Per2 PER2 Nuclear receptor co-regulator; Nucleolus; Transcription factor O54943 18627 1|1 D mouse S693-p 468399 ETVEDMAsGPESLDG carcinogenesis, induced; cell growth, induced 30746467 2 6 0 -LRRK2 LRRK2 EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, Ser/Thr (non-receptor); Protein kinase, TKL Q5S007 120892 12q12 human T1503-p 10426325 ALAKLRKtIINESLN molecular association, regulation; protein conformation; enzymatic activity, induced Other(INDUCES) 21806997 8 4 0 induces GTP binding, induces protein destabilization due to unfavourable conformation -Exoc8 EXOC8 Vesicle O54924 245709 19q12 rat S670-p 56663140 TFIRQNAsFLYDTVL molecular association, regulation exocytosis, inhibited Sec5(DISRUPTS); EXOC8(DISRUPTS) 28325821 1 2 0 -Traf6 TRAF6 EC 6.3.2.-; Ligase; UBIQUITIN LIGASE; Ubiquitin conjugating system; Ubiquitin ligase P70196 22034 2|2 E2 mouse K461-ub 1877141200 HEEVMDAkPELLAFQ signaling pathway regulation 32816906 1 0 0 important for ARC regulating TRAF6 Lys63-linked ubiquitination and the NF-kB signaling pathway -Rph3a rabphilin 3A Vesicle P47709 171039 12q16 rat S234-p 455904 GPPTRRAsEARMSTT intracellular localization 14-3-3 beta(INDUCES) 11466418; 22993210 5 0 2 hormone secretion -Pfn1 profilin 1 Actin-binding; Cytoskeletal; Motility/polarity/chemotaxis P62962 18643 11 B3|11 43.21 cM mouse T90-p 23135104 EFTMDLRtKSTGGAP Profilin molecular association, regulation; protein conformation cytoskeletal reorganization ACTB(INDUCES) 27228149 1 1 1 reduces overall actin polymerization in cells -CD6 CD6 Cell surface; Membrane protein, integral P30203 923 11q12.2 human S562-p 28095004 QYHPRSNsESSTSSG phosphorylation signaling pathway regulation 23711376 1 0 0 ERK1/2 phosphorylation, MAPK pathway activation -Pam PAM EC 1.14.17.3; EC 4.3.2.5; Lyase; Membrane protein, integral; Oxidoreductase; Vesicle P14925 25508 9q37 rat T946-p 455820 KGFDRVStEGSDQEK intracellular localization; enzymatic activity, induced 11524414; 20374556 2 4 0 -Cask CASK Adaptor/scaffold; EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, CAMK; Protein kinase, Ser/Thr (non-receptor) O70589 12361 X A1.1|X 8.43 cM mouse S51-p 1261103 DVAKFTSsPGLSTED Pkinase molecular association, regulation; intracellular localization liprin alpha 1(DISRUPTS) 18054859 1 3 0 promotes CASK recruitment to presynaptic membranes and interaction with presynaptic proteins (Veli, Mint1, neurexins, N-type voltage-gated calcium channels); ; promotes calcium influx into neurons; promotes synaptogenesis -Met Met EC 2.7.10.1; KINASE; Kinase, protein; Membrane protein, integral; Oncoprotein; Protein kinase, TK; Protein kinase, tyrosine (receptor) P16056 17295 6 A2|6 7.83 cM mouse Y1233-p 448471 DMYDKEYySVHNKTG PK_Tyr_Ser-Thr ubiquitination; enzymatic activity, induced carcinogenesis, induced; cell differentiation, induced; cell motility, induced; cell growth, induced 12244174; 19595710; 34580063; 37175792; 7708691 52 16 442 -AGO2 AGO2 EC 3.1.26.n2; RNA processing; RNA-binding Q9UKV8 27161 8q24.3 human Y529-p 17533104 LPGKTPVyAEVKRVG Piwi molecular association, regulation; intracellular localization; activity, inhibited carcinogenesis, induced; cell differentiation, induced DICER1(DISRUPTS) RNA(DISRUPTS) 21071408; 26443379; 26858302; 31981897; 35259248 5 1 0 -CHKB CHKB EC 2.7.1.32; EC 2.7.1.82; Kinase, other; Lipid Metabolism - glycerophospholipid Q9Y259 1120 22q13.33 human S40-p 3857922 PKRRRASsLSRDAER enzymatic activity, induced 27149373 1 7 4 -XRCC1 XRCC1 DNA repair, damage P18887 7515 19q13.31 human T358-p 143281205 PDWTRDStHLICAFA BRCT intracellular localization DNA repair, induced 28740101 1 1 0 recruitment of XRCC1 to DNA damage and binding to PARP1/PAR -RUNX1 AML1 iso8 DNA-binding; Oncoprotein; Transcription factor Q01196-8 861 21q22.12 human S48-p 452744 TPPSTALsPGKMSEA activity, induced; molecular association, regulation cell growth, induced; transcription, induced; cell growth, altered HDAC1(DISRUPTS); HDAC3(DISRUPTS) 18003885; 21059642 2 30 11 increases RUNX1 trans-activation; increases marrow progenitor proliferation -Smad3 SMAD3 DNA-binding; Nuclear receptor co-regulator; Transcription factor Q8BUN5 17127 9|9 C mouse T388-p 1243500 GAEYRRQtVTSTPCW MH2 activity, induced; intracellular localization 17991884 3 1 0 Nuclear translocation -Kcnn4 KCNN4 Channel, potassium; Membrane protein, integral; Membrane protein, multi-pass Q9QYW1 65206 1q21 rat T327-p 452144 AWMYYKHtRRKDSRA CaMBD activity, inhibited 15243742 2 0 0 -MECP2 MECP2 Transcription, coactivator/corepressor P51608 4204 Xq28 human S80-p 452713 AVPEASAsPKQRRSI molecular association, regulation apoptosis, altered; transcription, altered YB-1(INDUCES); SMC3(INDUCES) 19820693; 22615490 12 68 1 Phosphorylation of S80 and S229 leads to activation and repression of EGR2 expression. Phosphorylated S80 interacts with YB-1 in RNA dependent manner -Rps6ka1 p90RSK EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, AGC; Protein kinase, Ser/Thr (non-receptor); Translation Q63531 81771 5q36 rat S380-p 447990 HQLFRGFsFVATGLM Pkinase_C activity, induced; intracellular localization; phosphorylation; enzymatic activity, induced cell growth, induced; translation, induced 12618428; 35648763; 9430688 66 48 64 induces eEF2K phosphorylation -ATG16L1 ATG16L1 Adaptor/scaffold; Autophagy; Membrane protein, peripheral Q676U5 55054 2q37.1 human S278-p 15425208 PAGGLLDsITNIFGR protein stabilization autophagy, induced 28082356; 31126908 2 5 9 enhance cleavage of T300A ATG16L1 via phosphorylation on S278 -PRKAA2 AMPKA2 Autophagy; EC 2.7.11.1; EC 2.7.11.27; EC 2.7.11.31; KINASE; Kinase, protein; Protein kinase, CAMK; Protein kinase, Ser/Thr (non-receptor) P54646 5563 1p32.2 human K60-ub 27177169 RSLDVVGkIKREIQN Pkinase enzymatic activity, inhibited 31996460 1 1 0 -TIMELESS TIMELESS Transcription, coactivator/corepressor Q9UNS1 8914 12q13.3 human T1078-p 50613403 PPASGQEtFWRIPAK TIMELESS_C molecular association, regulation DNA repair, altered PARP1(DISRUPTS) 26456830 1 0 0 -Abcc9 ABCC9 Channel, potassium; Membrane protein, integral; Membrane protein, multi-pass; Transporter; Transporter, ABC family P70170 20928 6 G2|6 74.35 cM mouse S1351-p 483972 RTGSGKSsLSLAFFR ABC_tran activity, induced 17596331 1 0 0 -COPS5 COPS5 Adaptor/scaffold; DEUBIQUITINASE; EC 3.4.-.-; Nuclear receptor co-regulator; Protease; Transcription, coactivator/corepressor; Translation Q92905 10987 8q13.1 human S201-p 1827354807 KPPDEGPsEYQTIPL enzymatic activity, inhibited signaling pathway regulation 31950832 1 1 0 NFkB signaling pathway -Tbx21 TBX21 DNA-binding; Transcription factor Q9JKD8 57765 11|11 D mouse S508-p 458229 PSSGDSSsPAGAPSP molecular association, regulation NFkB-p65(INDUCES) 16275766 2 2 0 DNA binding activity of NFkB-p65 is reduced in the presence of T-bet -Fbp1 FBPase Carbohydrate Metabolism - fructose and mannose; Carbohydrate Metabolism - glycolysis and gluconeogenesis; Carbohydrate Metabolism - pentose phosphate pathway; EC 3.1.3.11; Mitochondrial; Phosphatase (non-protein) Q9QXD6 14121 13|13 B3 mouse S271-p 25292084 LYPANKKsPSGKLRL FBPase_C protein degradation; ubiquitination carcinogenesis, induced; cell growth, induced 36237339 1 1 1 -YWHAE 14-3-3 epsilon Adaptor/scaffold P62258 7531 17p13.3 human K118-ac 474724 AANTGESkVFYYKMK 14-3-3 molecular association, regulation SFRS6(DISRUPTS); PLEKHQ1(DISRUPTS); SFRS4(DISRUPTS); DOK3(DISRUPTS); TSC2(DISRUPTS); ARAF(DISRUPTS); LARP(DISRUPTS); SRm300(DISRUPTS); SF2(DISRUPTS); TSC22D1(DISRUPTS); GAB2(DISRUPTS); RAF1(DISRUPTS); VASP(DISRUPTS); HDAC4(DISRUPTS); TRA2B(DISRUPTS); GBF1(DISRUPTS) 19608861 0 5 2 -Plcl1 PLCL1 Phospholipase Q3USB7 227120 1|1 C1.2 mouse T94-p 453436 KCGGRKKtVSFSSMP molecular association, regulation PPP1CA(DISRUPTS) 15306641 1 7 5 -KCNC4 Kv3.4 Channel, potassium; Membrane protein, integral; Membrane protein, multi-pass Q03721 3749 1p13.3 human S9-p 451076 ISSVCVSsYRGRKSG Potassium_chann receptor inactivation, altered 9649584 1 0 0 -BAP1 BAP1 DEUBIQUITINASE; EC 3.4.19.12; Protease; Tumor suppressor; Ubiquitin conjugating system; Ubiquitin-specific protease Q92560 8314 3p21.1 human S597-p 482083 QGSQGSSsPVEKEVV intracellular localization DNA repair, induced 24347639 1 10 7 -IDH2 IDH2 Carbohydrate Metabolism - citrate (TCA) cycle; EC 1.1.1.42; Mitochondrial; Other Amino Acids Metabolism - glutathione; Oxidoreductase P48735 3418 15q26.1 human K384-ac 15291451 RGLEHRGkLDGNQDL Iso_dh enzymatic activity, inhibited 32457458 2 5 13 oncometabolite 2-hydroxyglutarate (2HG) production -YAP1 YAP1 Oncoprotein; Transcription, coactivator/corepressor P46937 10413 11q22.1 human K342-ub 603486520 PSTANSPkCQELALR protein degradation carcinogenesis, altered 36271031 1 2 0 -Zfp36 TTP DNA-binding; RNA-binding P22893 22695 7 A3-B1|7 16.72 cM mouse S178-p 451151 HVLRQSIsFSGLPSG activity, induced; protein stabilization; molecular association, regulation; intracellular localization; activity, inhibited translation, altered; transcription, induced 14-3-3 beta(INDUCES); CAF-1A(DISRUPTS); CAF-1B(DISRUPTS) 15014438; 16508015; 20595389; 26002976; 26019272; 31527197; 36961408 13 25 11 -POLH POLH DNA repair, damage; EC 2.7.7.7; Transferase Q9Y253 5429 6p21.1 human K328-sm 1877365912 CSKNFPGkTALATRE IMS_C intracellular localization; enzymatic activity, inhibited 32350109 1 1 0 -ACLY ACLY Carbohydrate Metabolism - citrate (TCA) cycle; EC 2.3.3.8; Lyase; Transferase P53396 47 17q21.2 human S455-p 448631 PAPSRTAsFSESRAD carcinogenesis, induced; signaling pathway regulation 26039450; 36269753 10 83 122 -GAREM2 FAM59B Unknown function Q75VX8 150946 2p23.3 human Y102-p 28850311 DVREPVRyFSSVEEV CABIT molecular association, regulation cell differentiation, induced; signaling pathway regulation GRB2(INDUCES) 24003223 1 0 0 -INSR INSR EC 2.7.10.1; KINASE; Kinase, protein; Membrane protein, integral; Protein kinase, TK; Protein kinase, tyrosine (receptor) P06213 3643 19p13.2 human S1332-p 451590 ENVPLDRsSHCQREE enzymatic activity, inhibited 8454604 2 0 0 -DBF4 DBF4 Cell cycle regulation; Protein kinase, regulatory subunit Q9UBU7 10926 7q21.12 human S502-p 23010417 FSTDNSGsQPKQKSD cell cycle regulation 22123827 1 0 0 DBF4 phosphorylaion is important for supressing DNA replication. -SOX10 SOX10 Cell development/differentiation; DNA-binding; Transcription factor P56693 6663 22q13.1 human K55-sm 3875804 PGELGKVkKEQQDGE Sox_N activity, induced; molecular association, regulation transcription, induced; transcription, inhibited EGR2(DISRUPTS); PAX3(DISRUPTS) 16494873; 29295999; 34087780 3 0 0 SOX10 sumoylation at K55 were essential for expression of SAMMSON induced by vemurafenib. -HEXIM1 HEXIM1 Motility/polarity/chemotaxis; Transcription factor O94992 10614 17q21.31 human Y274-p 5204763 FSETYERyHTESLQN HEXIM molecular association, regulation; intracellular localization transcription, inhibited CCNT1(DISRUPTS); CDK9(DISRUPTS); LARP7(DISRUPTS) 25900325 2 1 1 nuclear localization, inhibits proviral gene expression, inhibition of 7SK snRNP complex aassembly -Elk1 ELK1 DNA-binding; Transcription factor P41969 13712 X A1.3|X 16.45 cM mouse T369-p 22725901 TLTPVLLtPSSLPPS molecular association, regulation transcription, induced MED16(INDUCES); MED23(INDUCES); Trap100(INDUCES) 27738173 2 0 0 -TOB2 TOB2 Q14106 10766 22q13.2 human S163-p 22999102 PSFGQSPsPTFIPRS cell growth, inhibited 22252318 1 1 0 promote mRNA deadenylaion and decay and the ability to suppress proliferation -FOSL1 FRA1 DNA-binding; Transcription factor P15407 8061 11q13.1 human T217-p 1270902 LEPEALHtPTLMTTP protein stabilization cell motility, induced; transcription, induced 17371847; 27816489 2 0 0 -FSCN1 fascin Actin-binding; Cytoskeletal; Motility/polarity/chemotaxis Q16658 6624 7p22.1 human K250-ub 60122800 GKATKVGkDELFALE Fascin cytoskeletal reorganization 27879315 1 2 0 fascin bundling activity -AQP1 AQP1 Membrane protein, integral; Membrane protein, multi-pass; Transporter; Transporter, aquaporin family P29972 358 7p14.3 human T157-p 482806 VLCVLATtDRRRRDL MIP activity, induced; intracellular localization 17522053; 22334691 2 0 0 T157A/T239A double mutation inhibits AQP1 translocation to the plasma membrane following hypotonic exposure; phosphorylation by PKC increases ion currents and water permability of AQP1. -NPM/ALK NPM-ALK KINASE; Kinase, protein; Protein kinase, TK; Protein kinase, tyrosine (receptor) AAA58698 human Y664-p 27275123 TAPGAGHyEDTILKS cell growth, induced; transcription, induced 16469875; 17110082 4 2 2 -SMAD2 SMAD2 DNA-binding; Transcription factor Q15796 4087 18q21.1 human K39-ac 478912 EQNGQEEkWCEKAVK intracellular localization cell cycle regulation; cell growth, inhibited; transcription, induced; signaling pathway regulation 17478422; 29187201 2 1 0 -ACD ACD Adaptor/scaffold Q96AP0 65057 16q22.1 human S169-p 15407290 SNAGLSLsQLLDEMR molecular association, regulation TERT(INDUCES) 27396482 1 0 1 telomerase recruitment, telomere length regulation -Myocd myocardin Cell development/differentiation; Transcription factor Q8VIM5 214384 11|11 B3 mouse S628-p 3627510 VLSSTFLsPQCSPQH transcription, inhibited 16141410 1 0 0 -NFE2L2 NRF2 DNA-binding; Transcription factor Q16236 4780 2q31.2 human K506-ac 7106324 RDIRRRGkNKVAAQN bZIP_Maf molecular association, regulation transcription, induced DNA(INDUCES) 19273602 1 1 0 -Dlx5 DLX5 DNA-binding; Transcription factor P70396 13395 6 A1|6 2.83 cM mouse S217-p 1725301 SDPMACNsPQSPAVW transcription, induced 18056716 1 0 0 measured by Osx mRNA levels -Cavin1 PTRF Transcription initiation complex O54724 19285 11 D|11 63.95 cM mouse S42-p 452127 EEPSGTGsDELIKSD phosphorylation 21282370 1 26 1 regulates phosphorylation of HSL S557 (aka S563) and S651 (aka S660); regulates lipolysis in adipocytes -RIOK2 RIOK2 EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, Ser/Thr (non-receptor); Protein kinase, atypical Q9BVS4 55781 5q15 human S483-p 7446950 QYRTRTLsITSSGSA molecular association, regulation; intracellular localization cell growth, induced NOB1P(DISRUPTS) 34125833 1 5 1 -PRRG4 PRRG4 Membrane protein, integral Q9BZD6 79056 11p13 human Y189-p 1870790705 EDAGLPSyEQAVALT molecular association, regulation; ubiquitination; phosphorylation carcinogenesis, induced; cell motility, induced Src(INDUCES); NEDD4(INDUCES) 33037408 1 0 0 Robo1 ubiquitination; FAK phosphorylation -APP APP Apoptosis; Cell surface; Membrane protein, integral; Receptor, misc.; Transcription factor P05067 351 21q21.3 human Y757-p 448202 SKMQQNGyENPTYKF APP_amyloid molecular association, regulation GRB2(INDUCES); Abl(INDUCES); Src(INDUCES); PLCG1(INDUCES); GRB7(INDUCES); SHC2(INDUCES); PIN1(INDUCES); LYN(INDUCES); DAB1(INDUCES); PLCG2(INDUCES); NCK1(INDUCES); SHC3(INDUCES); SHC1(INDUCES); CRK(INDUCES) 19602287 14 20 864 -UCHL3 UCHL3 EC 3.4.19.12; Protease; Ubiquitin conjugating system P15374 7347 13q22.2 human S75-p 482705 EEEEKIKsQGQDVTS Peptidase_C12 molecular association, regulation; enzymatic activity, induced DNA repair, induced ubiquitin(INDUCES) 27941124; 36142702 2 3 3 RAD51 focus formation, HR, and radiosensitivity -PTPN1 PTP1B EC 3.1.3.48; Motility/polarity/chemotaxis; PHOSPHATASE; Phosphatase; Protein phosphatase, tyrosine (non-receptor) P18031 5770 20q13.13 human K347-sm 12004413 EDKDCPIkEEKGSPL enzymatic activity, inhibited signaling pathway regulation 17159996 1 0 0 insulin signaling -Trpv2 TRPV2 Channel, cation; Membrane protein, integral; Membrane protein, multi-pass Q9WUD2 29465 10q23 rat S6-p 29631548 __MTSASsPPAFRLE cell growth, induced 26416880 1 3 0 neurite outgrowth -TAGLN2 TAGLN2 Cytoskeletal; Motility/polarity/chemotaxis P37802 8407 1q23.2 human S145-p 31885453 ARDDGLFsGDPNWFP protein stabilization carcinogenesis, induced; cell growth, induced 30041673 1 3 0 essential for Kras- regulated cell proliferation -ASXL2 ASXL2 DNA-binding Q76L83 55252 2p23.3 human R639-m2 27269956 HPSQVSPrARFPVSI cell differentiation, inhibited; apoptosis, inhibited; transcription, inhibited MLL3(DISRUPTS) DNA(DISRUPTS) 36197977 1 2 1 CARM1 inhibition up-regulates apoptosis and differentiation related genes -Oprd1 DOR-1 GPCR, family 1; Membrane protein, integral; Membrane protein, multi-pass; Receptor, GPCR P32300 18386 4 D2.3|4 64.78 cM mouse Y318-p 452090 SSLNPVLyAFLDENF 7tm_1 activity, induced; receptor internalization, altered 10925143 1 0 0 -LAT LAT iso2 Adaptor/scaffold; Membrane protein, integral O43561-2 27040 16p11.2 human Y110-p 450202 GANSVASyENEEPAC LAT molecular association, regulation; phosphorylation transcription, altered GRB2(INDUCES) 11395491 1 1 1 leads to ERK phosphorylation, NF-AT transcription -FH fumarase Carbohydrate Metabolism - citrate (TCA) cycle; EC 4.2.1.2; Lyase; Mitochondrial; Tumor suppressor P07954 2271 1q43 human T236-p 49156200 IKIGRTHtQDAVPLT Lyase_1 molecular association, regulation H2AZ(INDUCES) DNA(INDUCES) 26237645 1 0 0 non-homologous end-joining, inhibits methylation -MEF2D MEF2D DNA-binding; Transcription factor Q14814 4209 1q22 human K267-m1 31094532 QLGAPSRkPDLRVIT molecular association, regulation cell differentiation, inhibited; transcription, inhibited DNA(DISRUPTS) 24078251 1 1 0 -Prkcz PKCZ EC 2.7.11.13; KINASE; Kinase, protein; Protein kinase, AGC; Protein kinase, Ser/Thr (non-receptor) P09217 25522 5q36 rat S186-p 3136104 TCRRHMDsVMPSQEP molecular association, regulation 14-3-3 beta(INDUCES); RAF1(INDUCES) 10620507 2 0 0 -CTNNB1 CTNNB1 Actin-binding; Cell adhesion; Motility/polarity/chemotaxis; Nuclear receptor co-regulator; Oncoprotein; Transcription factor P35222 1499 3p22.1 human S37-p 447582 YLDSGIHsGATTTAP protein degradation; protein stabilization; molecular association, regulation; ubiquitination; intracellular localization; activity, inhibited; neddylation cell cycle regulation; carcinogenesis, induced; carcinogenesis, inhibited; apoptosis, induced; cell growth, inhibited; transcription, induced; cell motility, inhibited; signaling pathway regulation; transcription, altered; cell adhesion, altered; cytoskeletal reorganization; transcription, inhibited; cell growth, altered CBLL1(INDUCES); TRAF2(DISRUPTS) 12000790; 12027456; 15829978; 17008323; 17018282; 19060929; 19061640; 19667122; 20300119; 20419129; 22025562; 22234184; 26908451; 31911618; 32041324; 32046730; 32210470; 33651074; 33832512; 34117362; 34290402; 34326276; 34749529; 35064015; 35065073; 35108540; 35320710; 35347116; 36575468; 36941998; 37369481; 37400529; 9312064 110 3 12 -Notch1 Notch 1 Membrane protein, integral; Motility/polarity/chemotaxis; Oncoprotein; Receptor, misc.; Transcription factor Q01705 18128 2 A3|2 18.91 cM mouse K2068-ac 18899509 EGSYETAkVLLDHFA Ank_2 protein stabilization; ubiquitination 21499261 1 1 0 -Nr5a1 STF-1 Nuclear receptor; Transcription, coactivator/corepressor P33242 26423 2 B|2 24.42 cM mouse K194-sm 2798300 AFSNRTIkSEYPEPY molecular association, regulation; activity, inhibited; phosphorylation signaling pathway regulation; transcription, altered; transcription, inhibited SRC-1(DISRUPTS); GEMIN3(INDUCES); CDK7(DISRUPTS) 15192080; 15713642; 19015234; 21820362; 24232453 9 0 0 E199A Increases NR5A1?s Interaction with CDK7 and SRC1 ; affects hedgehog signaling; inhibits STF-1 S203 phosphorylation and its activation -Trpv2 TRPV2 Channel, cation; Membrane protein, integral; Membrane protein, multi-pass Q9WUD2 29465 10q23 rat S47-p 12738661 QREDRNSsPQIKVNL cell growth, induced 26416880 1 6 0 neurite outgrowth -RASSF1 RASSF1 iso2 Tumor suppressor Q9NS23-2 11186 3p21.31 human S175-p 13258707 LKLVRPVsVPSSKKP molecular association, regulation apoptosis, inhibited TRAIL-R1(DISRUPTS); 14-3-3 zeta(INDUCES); 14-3-3 epsilon(INDUCES); TNF-R1(DISRUPTS); MOAP1(DISRUPTS) 20069457 1 0 0 -VDAC1 VDAC1 Channel, misc.; Membrane protein, integral; Mitochondrial P21796 7416 5q31.1 human T107-p 3181799 DSSFSPNtGKKNAKI Porin_3 protein stabilization 25296756 1 19 2 -Fli1 FLI1 DNA-binding; Oncoprotein; Transcription factor P26323 14247 9 A4|9 17.74 cM mouse S10-p 8046505 GTIKEALsVVSDDQS molecular association, regulation transcription, inhibited AML1(DISRUPTS) 19470763 1 2 0 inhibits megakaryocyte maturation -Cttn Cortactin Actin-binding; Cytoskeletal; Motility/polarity/chemotaxis Q60598 13043 7|7 F5 mouse Y497-p 57807006 GITAIALyDYQAAGD SH3_9 molecular association, regulation MTUS2(DISRUPTS) 27451391 1 0 0 Y497, Y499, Y541 are major residues for interaction -S100A11 S100A11 Calcium-binding; Cell cycle regulation; DNA replication P31949 6282 1q21.3 human T10-p 10888705 KISSPTEtERCIESL S_100 intracellular localization cell cycle regulation; cell growth, altered NCL(INDUCES) 10851017; 14623863 2 2 7 Nuclear translocation is mediated by T10 phosphorylation. Calcium induced growth inhibition is mediated by T10 and S94 phosphorylation.; induces nuclear localization at cell confluency -ATP7B ATP7B EC 3.6.3.54; Hydrolase; Membrane protein, integral; Membrane protein, multi-pass; Transporter; Transporter, ion channel; Vesicle P35670 540 13q14.3 human S1121-p 11267007 AHSERPLsAPASHLN Hydrolase protein stabilization; intracellular localization 21189263 1 1 0 protein trafficking -VTN VTN Cell adhesion; Motility/polarity/chemotaxis; Secreted; Secreted, signal peptide P04004 7448 17q11.2 human S397-p 452178 NQNSRRPsRATWLSL molecular association, regulation; protein conformation; phosphorylation SERPINE1(DISRUPTS) 11795878 4 0 0 decreases accessibility of CKII to phosphorylate VTN -CREBBP CBP ACETYLTRANSFERASE; Acetyltransferase; DNA-binding; EC 2.3.1.48; Motility/polarity/chemotaxis; Nuclear receptor co-regulator; Transcription, coactivator/corepressor Q92793 1387 16p13.3 human R601-me 478320 EHVTQDLrSHLVHKL KIX protein conformation 12795599 2 0 0 -Oprm1 MOR-1 GPCR, family 1; Membrane protein, integral; Membrane protein, multi-pass; Receptor, GPCR P42866 18390 10 A1|10 1.85 cM mouse T376-p 20727901 NTREHPStANTVDRT receptor internalization, induced; molecular association, regulation endocytosis, induced; signaling pathway regulation ARRB2(INDUCES) 21868358; 23239825; 30018083; 32234959 7 2 0 regulates B-arrestin signaling; endocytosis of MOR-1 -Gli2 GLI2 C2H2-type zinc finger protein; Oncoprotein; Transcription factor Q0VGT2 14633 1 E2.3|1 52.17 cM mouse R225-me 1877628101 RVTPRLSrKRALSIS molecular association, regulation signaling pathway regulation SUFU(DISRUPTS) 31000813 1 0 0 increases Shh signaling leading to prevention of cellular senescence -RUNX1 AML1 DNA-binding; Oncoprotein; Transcription factor Q01196 861 21q22.12 human K43-ac 459072 AGAALAGkLRSGDRS molecular association, regulation cell growth, induced; transcription, induced DNA(INDUCES) 14752096 1 4 10 transformation increased -CHRM2 mAChR M2 GPCR, family 1; Membrane protein, integral; Membrane protein, multi-pass; Receptor, GPCR P08172 1129 7q33 human S288-p 459104 ESSNDSTsVSAVASN 7tm_1 receptor internalization, altered 9162044 3 0 0 Mutation of S286 T287 S288 S290 to A caused a faster rate and a greater extent of receptor internalization after agonist stimulation (transients only, not observed in stables). Mutation of all 8 sites prevented internalization (in both transients and stables). -CDK2 CDK2 Cell cycle regulation; EC 2.7.11.22; KINASE; Kinase, protein; Protein kinase, CMGC; Protein kinase, Ser/Thr (non-receptor) P24941 1017 12q13.2 human T14-p 447738 VEKIGEGtYGVVYKA Pkinase protein stabilization; enzymatic activity, inhibited; protein conformation cell cycle regulation 12912980; 1396589; 15632290; 23671119 12 110 1499 required for recovery from replication stress; loss of inhibitory phosphorylation causes DNA damage -TP53BP1 53BP1 DNA repair, damage; Transcription, coactivator/corepressor Q12888 7158 15q15.3 human K1628-ac 1876695601 NLVEGKRkRRSNVSS molecular association, regulation; intracellular localization DNA repair, altered H2A.1(DISRUPTS) 29190394 1 1 0 acetylation status regulates recruitment to foci, acetylation promotes DNA end resection and HR -Clock CLOCK ACETYLTRANSFERASE; Acetyltransferase; DNA-binding; EC 2.3.1.48; Transcription factor O08785 12753 5 C3.3|5 40.63 cM mouse S845-p 23094535 LPRHRTDsLTDPSKV molecular association, regulation; intracellular localization transcription, induced 29588368 1 6 1 S845 mice have altered circadian gene expression in peripheral tissues; regulates nuclear translocation via binding to 14-3-3 -DGCR8 DGCR8 Nucleolus; RNA processing; RNA-binding Q8WYQ5 54487 22q11.21 human S35-p 34501609 QALPREQsPPPPLQT protein stabilization 24239349 0 3 0 -CGAS cGAS EC 2.7.7.86 Q8N884 115004 6q13 human K198-ac 1868968400 DHLLLRLkCDSAFRG transcription, induced 32345711 1 1 0 inducing cytokine expression -KAT5 Tip60 ACETYLTRANSFERASE; Acetyltransferase; EC 2.3.1.48; Nuclear receptor co-regulator; Nucleolus Q92993 10524 11q13.1 human K187-ac 52498002 VAAQPGRkRKSNCLG protein degradation; intracellular localization apoptosis, altered 25301942 1 0 0 HDAC3 increased the TIP60 half-life, and the ubiquitination level of TIP60, nuclear localization, cytoplasm and nucleus with HDAC3 expressed, TIP60 deacetylation increases its resistance to apoptosis -SH2D2A TSAd Adaptor/scaffold Q9NP31 9047 1q23.1 human Y280-p 449440 PKPSNPIyNEPDEPI molecular association, regulation Lck(INDUCES) 18541536 1 3 94 -GRIK2 GluR6 Channel, calcium; Channel, ligand-gated; Membrane protein, integral; Membrane protein, multi-pass Q13002 2898 6q16.3 human C858-pa 27247801 QLEKRSFcSAMVEEL sumoylation; intracellular localization; phosphorylation; palmitoylation endocytosis, altered 37868810 2 0 0 palmitoylation maintains surface expression and regulates agonist -induced internalisation -GLI1 GLI1 C2H2-type zinc finger protein; Oncoprotein; Transcription factor P08151 2735 12q13.3 human S116-p 1877717202 FINSRCTsPGGSYGH activity, induced; molecular association, regulation transcription, induced SUFU(DISRUPTS) 35831023 1 0 0 -ARID3A Bright Transcription factor Q99856 1820 19p13.3 human K398-sm 7780000 ITPAPKIkKEEDSAI molecular association, regulation transcription, induced E2F1(DISRUPTS) 19436740 1 0 0 -Kit Kit EC 2.7.10.1; KINASE; Kinase, protein; Membrane protein, integral; Oncoprotein; Protein kinase, TK; Protein kinase, tyrosine (receptor) P05532 16590 5 C3.3|5 39.55 cM mouse Y571-p 448014 EEINGNNyVYIDPTQ activity, induced; molecular association, regulation cell motility, altered; cell growth, altered GAB2(INDUCES); SOCS6(INDUCES); SHC1(INDUCES); SHP-2(INDUCES); LNK(INDUCES) 14707129; 16873377; 18753636 13 3 18 -ATG13 ATG13 Autophagy; Vesicle O75143 9776 11p11.2 human S44-p 1869357207 ICTRSSSsPTGSDWF cell cycle regulation; autophagy, induced; cell growth, induced 32516310 1 1 0 -CCDC50 CCDC50 Inhibitor Q8IVM0 152137 3q28 human Y145-p 454594 RAYADSYyYEDGGMK molecular association, regulation EGFR(INDUCES) 16803894 1 12 21 inhibits the down-regulation of EGFR -Gsk3b GSK3B EC 2.7.11.1; EC 2.7.11.26; KINASE; Kinase, protein; Protein kinase, CMGC; Protein kinase, Ser/Thr (non-receptor) Q9WV60 56637 16|16 B3 mouse T356-p 37043704 KLPNGRDtPALFNFT enzymatic activity, inhibited; phosphorylation cell differentiation, induced; transcription, induced 25477508 1 0 0 decreased phosphorylation of Tau at Thr-212, obesity-resistant phenotype; NFAT transcription induced -Atxn1 ataxin-1 Nuclear export; RNA-binding P54254 20238 13 A5|13 21.98 cM mouse K585-ub 40320205 AEISNDLkIDSSTVE AXH protein degradation; intracellular localization 25641559 1 1 0 induces cytoplasmic-aggregate formation from decreased UBE2E1-mediated degradation -Pklr PKLR iso2 Carbohydrate Metabolism - glycolysis and gluconeogenesis; Carbohydrate Metabolism - pyruvate; EC 2.7.1.40; Kinase, other; Nucleotide Metabolism - purine P12928-2 24651 2q34 rat S12-p 1218250 AGYLRRAsVAQLTQE molecular association, regulation; enzymatic activity, inhibited; protein conformation PKLR iso2(DISRUPTS) 19320443; 22878931 5 1 6 Mutations at position 9 and 10 changed affected enzyme activity and decreased binding of the substrate phoenolpyruvate, but not another substrate ADP. -BUB1 BUB1 Cell cycle regulation; EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, Other; Protein kinase, Ser/Thr (non-receptor) O43683 699 2q13 human S969-p 20722066 FTAKCETsGFQCVEM Pkinase enzymatic activity, induced 26658523 1 2 0 -Plin1 perilipin 1 Lipid-binding Q8CGN5 103968 7|7 D2 mouse S492-p 459628 EKPARRVsDSFFRPS activity, induced; molecular association, regulation; intracellular localization cytoskeletal reorganization ABHD5(DISRUPTS) 16488886; 17114792; 19116774; 19850935; 23825572 12 12 0 when S517 is phosphorylated, S492 phosphorylation enhances PKA-stimulated lipolysis in adipocytes; phosphorylation of site facilitates lipolysis of lipid droplets.; induces dissociation of ABHD5 from perilipin and its association with Atgl; hosphorylation of S492 induces scattering of lipid droplets throughout the cytoplasm. ; induces Cytoplasmic Lipid Droplet (CLD) dispersion -Kcnj3 GIRK1 Channel, potassium; Membrane protein, integral; Membrane protein, multi-pass P63251 50599 3q21 rat S385-p 4706226 NSKERHNsVECLDGL activity, induced 19765080 3 4 1 -DPYSL2 CRMP-2 iso3 Microtubule-binding; Motility/polarity/chemotaxis NP_001184222 1808 8p21.2 human T619-p 454386 SVTPKTVtPASSAKT carcinogenesis, altered; cell motility, altered 24036111 33 36 35 -MIP AQP0 Channel, misc.; Membrane protein, integral; Membrane protein, multi-pass; Transporter, aquaporin family P30301 4284 12q13.3 human S235-p 450116 KSISERLsVLKGAKP molecular association, regulation; protein conformation Calmodulin(DISRUPTS) 18081321; 27660387 6 9 0 phosphorylation of AQP0 disrupts calcium sensitivity by altering the AQP0-CaM interaction interface -Mknk1 Mnk1 EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, CAMK; Protein kinase, Ser/Thr (non-receptor); Translation O08605 17346 4|4 D1 mouse S203-p 11507613 SGVKLNNsCTPITTP Pkinase enzymatic activity, induced 16162500 1 0 0 -INSR INSR EC 2.7.10.1; KINASE; Kinase, protein; Membrane protein, integral; Protein kinase, TK; Protein kinase, tyrosine (receptor) P06213 3643 19p13.2 human S1216-p 3103704 KDGVFTTsSDMWSFG PK_Tyr_Ser-Thr enzymatic activity, induced 10866039 1 0 0 -Jak3 JAK3 EC 2.7.10.2; KINASE; Kinase, protein; Protein kinase, TK; Protein kinase, tyrosine (non-receptor) Q62137 16453 8 B3.3|8 34.43 cM mouse Y820-p 1876350204 FEERHLKyISLLGKG PK_Tyr_Ser-Thr molecular association, regulation; phosphorylation cell growth, inhibited; transcription, inhibited STAT5A(DISRUPTS) 35192696 2 0 0 inhibits autophosphorylation and STAT5 phosphorylation -Pawr PAR-4 Apoptosis Q62627 64513 7q21 rat S124-p 28030293 GDEEEPDsAPEKGRS apoptosis, inhibited; transcription, induced 24457960 1 3 0 -Oxsr1 OSR1 EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, STE; Protein kinase, Ser/Thr (non-receptor) Q6P9R2 108737 9|9 F3 mouse S325-p 456504 VRRVPGSsGRLHKTE enzymatic activity, induced; phosphorylation 24808538; 34289367 14 12 0 -LONP1 PRSS15 DNA-binding; EC 3.4.21.-; Mitochondrial; Protease; RNA-binding P36776 9361 19p13.3 human S181-p 1869121003 NESDVVEsLDEIYHT LON_substr_bdg enzymatic activity, induced carcinogenesis, inhibited 31406245 1 1 0 regulation of mitochondrial bioenergetics -Cftr CFTR Channel, chloride; EC 3.6.3.49; Hydrolase; Membrane protein, integral; Membrane protein, multi-pass; Transporter; Transporter, ABC family P26361 12638 6 A2|6 8.1 cM mouse S659-p 11929100 QFTEERRsSILTETL CFTR_R protein conformation 19927121 0 1 0 in vitro -Tp53 p53 Activator; DNA-binding; Motility/polarity/chemotaxis; Nuclear receptor co-regulator; Transcription factor; Tumor suppressor P10361 24842 10q24 rat K379-ac 458983 GQSTSRHkKPMIKKV autophagy, induced 23055316 35 6 0 paraplegia -ARAF ARAF EC 2.7.11.1; KINASE; Kinase, protein; Oncoprotein; Protein kinase, Ser/Thr (non-receptor); Protein kinase, TKL P10398 369 Xp11.3 human Y302-p 455522 GYRDSGYyWEVPPSE activity, induced 9020159 1 6 91 -Ndufa10 NDUFA10 EC 1.6.5.3; EC 1.6.99.3; Energy Metabolism - oxidative phosphorylation; Mitochondrial; Oxidoreductase Q99LC3 67273 1|1 D mouse S250-p 32001601 KTFLPKMsEMCEVLV dNK enzymatic activity, induced apoptosis, inhibited; signaling pathway regulation 24652937 2 1 0 ATP synthesis and mitochondria were rescued; phosphorylation rescued ubiquinone reductase activity of Complex I, maintained neurotransmitter release at NMJ -CEP68 CEP68 Cytoskeletal Q76N32 23177 2p14 human S332-p 37046602 ADPVLQDsGVDLDSF protein degradation cytoskeletal reorganization 25503564 1 1 0 Centriole separation -Gab2 GAB2 Adaptor/scaffold Q9Z1S8 14389 7|7 E1 mouse S591-p 62877800 PVPSGTNsPAPKKST molecular association, regulation PIK3R1(DISRUPTS) 28096188 1 0 0 -OSBP OSBP Lipid-binding P16258 rabbit S242-p 484804 TALQRSLsELESLKL intracellular localization exocytosis, inhibited 20444975 2 45 16 impairment of CERT translocation to the Golgi; promotes Golgi fragmentation -EYA3 EYA3 EC 3.1.3.48; PHOSPHATASE; Protein phosphatase, tyrosine (non-receptor) Q99504 2140 1p35.3 human Y96-p 1869778704 AYPGQTQyQTLQQTQ cell growth, altered 31847183 1 0 0 -GBF1 GBF1 GEF; GEF, ARF Q92538 8729 10q24.32 human T1338-p 454448 GKIHRSAtDADVVNS intracellular localization cell cycle regulation 23418352 4 17 31 attenuates membrane association; required for mitosis -PRLR PRLR Membrane protein, integral; Receptor, cytokine P16471 5618 5p13.2 human S349-p 451641 YLDPDTDsGRGSCDS receptor internalization, induced; protein degradation; molecular association, regulation; ubiquitination; phosphorylation cell motility, altered; transcription, altered; cell growth, altered BTRC(INDUCES); FBW1B(INDUCES) 15082796; 16278670; 18252943; 19276348 4 0 0 -Ezr Ezrin Cytoskeletal; Motility/polarity/chemotaxis P26040 22350 17|17 A1 mouse T235-p 449293 YEKDDKLtPKIGFPW FERM_C activity, induced; intracellular localization cytoskeletal reorganization 12769842 1 0 0 The expression of activated variants of ezrin T234D,T566D) did induce a morphological reminiscent of the senescent phenotype. -SIT1 SIT Adaptor/scaffold; Membrane protein, integral Q9Y3P8 27240 9p13.3 human Y148-p 451883 GPGTPVKySEVVLDS molecular association, regulation SHP-2(INDUCES) 10209036 2 7 221 -Prkce PKCE EC 2.7.11.13; KINASE; Kinase, protein; Protein kinase, AGC; Protein kinase, Ser/Thr (non-receptor) P16054 18754 17|17 E4 mouse T710-p 450184 TREEPILtLVDEAII Pkinase_C enzymatic activity, induced 12640464 3 24 33 -CACB CACNA1C Channel, calcium; Membrane protein, integral; Membrane protein, multi-pass P15381 100101555 rabbit S1829-p 451189 EGHGSPLsPAVRAQE CAC1F_C activity, induced 15044319 1 1 0 -SIPA1L1 SIPA1L1 GAP; GAP, Ras O43166 26037 14q24.2 human S1632-p 3892364 SLPLRRPsYTLGMKS SPAR_C molecular association, regulation PSD-95(INDUCES) 22117215 1 16 63 Fluorescence Polarization -PPP1R16B PPP1R16B Motility/polarity/chemotaxis; Protein phosphatase, regulatory subunit Q96T49 26051 20q11.23 human S333-p 486244 LRHKSSLsRRTSSAG phosphorylation 31315927 2 1 0 increases phosphorylation of MLC2 -PLK4 PLK4 EC 2.7.11.21; KINASE; Kinase, protein; Nucleolus; Protein kinase, Other; Protein kinase, Ser/Thr (non-receptor) O00444 10733 4q28.1 human K45-ac 62518203 VAIKMIDkKAMYKAG Pkinase enzymatic activity, inhibited; protein conformation; phosphorylation cell cycle regulation 27796307 1 1 0 inhibits phosphorylation of its kinase domain, prevents centrosome amplification -Dynlt1 DYNLT1 Microtubule-binding; Motility/polarity/chemotaxis; Motor P51807 21648 17 A1|17 3.97 cM mouse T94-p 456225 SSTDGSCtVRWENKT Tctex-1 activity, induced; molecular association, regulation; intracellular localization cell cycle regulation; cell growth, induced; cell differentiation, induced; cytoskeletal reorganization ARHGEF2(INDUCES); DYNC1I1(DISRUPTS) 22405273; 23954591 7 0 0 ciliary resorption; T94 phosphorylation promotes proliferation of neural progenitors through modulation of ciliary resorption and G1 length. -CARD11 CARD11 Adaptor/scaffold Q9BXL7 84433 7p22.2 human K696-ub 27738302 GSFVHSVkPGSLAEK transcription, induced 23322406 1 0 0 induces NF-kB activation -Syngap1 SynGAP GAP; GAP, Ras Q9QUH6 192117 20p12 rat S1138-p 451016 PSITKQHsQTPSTLN DUF3498 activity, induced; molecular association, regulation; intracellular localization PSD-95(DISRUPTS) 14970204; 25569349 3 2 0 SynGAP dispersion from dendritic spines, Ras activity and GluA1 tafficking during LTP -PLK1 PLK1 EC 2.7.11.21; KINASE; Kinase, protein; Protein kinase, Other; Protein kinase, Ser/Thr (non-receptor) P53350 5347 16p12.2 human K191-m2 1879760600 LNEDLEVkIGDFGLA enzymatic activity, inhibited cell cycle regulation; cytoskeletal reorganization 31863092 1 0 0 control of PLK1 activity at kinetochores, kinetochore-microtubule attachments, spindle microtubule dynamics during mitosis -Rufy3 RUFY3 Cell development/differentiation Q9D394 52822 5 E1|5 43.77 cM mouse S34-p 4775177 YLCKFRVsMDGEWLC protein stabilization; enzymatic activity, inhibited; activity, inhibited cytoskeletal reorganization 31221560 1 6 3 protects axons from degeneration, inhibits activity of itself and of DEVDase -Cebpa C/EBP-alpha DNA-binding; Transcription factor P53566 12606 7 B2|7 21.02 cM mouse T226-p 449825 GHPTPPPtPVPSPHA transcription, induced; transcription, inhibited 10567568; 17290224 8 0 0 -BTLA BTLA Membrane protein, integral Q7Z6A9 151888 3q13.2 human Y257-p 454099 ENKPGIVyASLNHSV phosphorylation signaling pathway regulation 32437509 2 1 6 inhibits IL2 production, phosphorylation of CD3Z and CD28, and hence T cell signaling -Prkaa1 AMPKA1 Autophagy; EC 2.7.11.1; EC 2.7.11.26; EC 2.7.11.27; EC 2.7.11.31; KINASE; Kinase, protein; Protein kinase, CAMK; Protein kinase, Ser/Thr (non-receptor) Q5EG47 105787 15|15 A1 mouse T183-p 448786 SDGEFLRtSCGSPNY Pkinase protein degradation; intracellular localization; phosphorylation; enzymatic activity, induced carcinogenesis, induced; autophagy, induced; cell growth, induced; apoptosis, inhibited; cytoskeletal reorganization; transcription, altered; cell growth, altered AMPKA1(INDUCES) 11549258; 11994296; 12456889; 14985505; 17482548; 17525164; 18202101; 19176702; 19942859; 21478880; 24563466; 24928508; 33531625; 33779513; 35256937 228 16 33 -KHDRBS1 KHDRBS1 RNA-binding Q07666 10657 1p35.2 human R325-m1 476704 PVRGAITrGATVTRG intracellular localization 12529443 1 5 37 -DLG1 DLG1 Adaptor/scaffold; Motility/polarity/chemotaxis Q12959 1739 3q29 human T209-p 35547401 VNTDSLEtPTYVNGT MAGUK_N_PEST molecular association, regulation; intracellular localization cytoskeletal reorganization GKAP1(DISRUPTS) 15729360 1 1 0 -TUBA1C TUBA1C Cytoskeletal; Motility/polarity/chemotaxis Q9BQE3 84790 12q13.12 human S165-p 8046500 SVDYGKKsKLEFSIY Tubulin activity, induced; intracellular localization; protein conformation cell motility, induced; cell motility, altered; cytoskeletal reorganization 19406749; 24574051; 35799350 3 0 1 -MOB1A MOB1A Protein kinase, regulatory subunit Q9H8S9 55233 2p13.1 human T12-p 34669905 FSSRSSKtFKPKKNI activity, induced; molecular association, regulation; protein conformation; phosphorylation signaling pathway regulation NDR1(INDUCES); MST2(INDUCES); LATS1(INDUCES); MST1(DISRUPTS) 26108669; 28373297; 32513747 3 2 3 Mst2 binding to Mob1 suffices to activate Mob1for Lats1 binding.; Fluorescence polarization ; induces YAP1 phosphorylation, manipulates the conserved Hippo pathway -EPHA2 EphA2 EC 2.7.10.1; KINASE; Kinase, protein; Membrane protein, integral; Protein kinase, TK; Protein kinase, tyrosine (receptor) P29317 1969 1p36.13 human S892-p 3189622 ADFDPRVsIRLPSTS signaling pathway regulation 32413552 1 13 58 MEK-ERK-RSK signaling -PAPOLA PAP-alpha EC 2.7.7.19; RNA processing; RNA splicing; Transferase P51003 10914 14q32.2 human K650-ac 466633 PTPIVGVkRTSSPHK molecular association, regulation; intracellular localization CPSF6(DISRUPTS); CFIM25(DISRUPTS) 17172643 1 3 17 cytoplasmic localization -TRIM29 TRIM29 Transcription factor; UBIQUITIN LIGASE; Ubiquitin ligase Q14134 23650 11q23.3 human S550-p 31836501 GYPSLMRsQSPKAQP molecular association, regulation DNA repair, induced; apoptosis, inhibited; transcription, inhibited RNF8(INDUCES); DVL2(DISRUPTS) 24469230; 26381412 2 0 0 -DDX5 DDX5 EC 3.6.4.13; Helicase; Nuclear receptor co-regulator; Nucleolus; RNA splicing; RNA-binding; Spliceosome P17844 1655 17q23.3 human K43-ac 15211501 NPGEKLVkKKWNLDE protein stabilization; molecular association, regulation carcinogenesis, induced; transcription, induced HDAC1(INDUCES); HDAC2(INDUCES) 20663877 1 1 0 -Mdm4 MDM4 EC 6.3.2.-; Ligase; UBIQUITIN LIGASE; Ubiquitin conjugating system; Ubiquitin ligase O35618 17248 1 E4|1 57.75 cM mouse S367-p 457676 PDCRRTIsAPVVRPK protein degradation; molecular association, regulation cell cycle regulation; apoptosis, inhibited; signaling pathway regulation 14-3-3 gamma(INDUCES) 17823617; 19573810; 22556425; 24190973 21 11 2 -FUS hnRNP P2 DNA-binding; Nuclear receptor co-regulator; Oncoprotein; RNA splicing; RNA-binding; SUMO LIGASE P35637 2521 16p11.2 human S183-p 1878186706 NYGQDQSsMSSGGGS molecular association, regulation hnRNP P2(DISRUPTS) 35753345 1 1 0 -Steap4 STEAP4 EC 1.16.1.-; Membrane protein, integral; Membrane protein, multi-pass; Oxidoreductase Q923B6 117167 5|5 A1 mouse K97-ub 8084100 TELVDYLkGKVLVDV F420_oxidored protein degradation 35747386 1 1 1 -Mef2a MEF2A DNA-binding; Motility/polarity/chemotaxis; Transcription factor Q2MJT0 309957 1q22 rat S192-p 7533201 ATLHRNVsPGAPQRP activity, induced apoptosis, inhibited; transcription, induced 17630987 1 1 0 -MITF MITF iso9 DNA-binding; Oncoprotein; Transcription factor O75030-9 4286 3p13 human S298-p 448503 QARAHGLsLIPSTGL DUF3371 activity, induced transcription, altered 10587587 2 1 0 -Mastl MASTL EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, AGC; Protein kinase, Ser/Thr (non-receptor) Q8C0P0 67121 2|2 A3 mouse T206-p 18012011 PKQDYSRtPGQVLSL intracellular localization 24101512 1 2 0 export to the cytoplasm -FOXA1 FOXA1 DNA-binding; Transcription factor P55317 3169 14q21.1 human K295-me 1881209000 KGGPESRkDPSGASN protein stabilization; molecular association, regulation; methylation cell cycle regulation; carcinogenesis, induced; cell growth, induced USP7(INDUCES) 33827814 1 0 0 methylation prevents it's ubiquitylation and increases protein stability, androgen-dependent prostate cancer (PACa) growth -CREB1 CREB DNA-binding; Transcription factor P16220 1385 2q33.3 human S100-p 451809 ESEDSQEsVDSVTDS pKID molecular association, regulation; phosphorylation CBP(INDUCES) 17209043 8 1 1 mutation to alanine decreases S121 phosphorylation in cells treated with ionizing radiation -Asap1 DDEF1 GAP; GAP, ARF; Motility/polarity/chemotaxis Q9QWY8 13196 15|15 D1 mouse Y308-p 450437 PKEVGGLyVASRANS molecular association, regulation; activity, inhibited Pyk2(INDUCES) Other(DISRUPTS) 12771146; 16413287 2 0 1 leads to less binding to phospholipids (including P(4,5)P2, PI(3,4,5)P3, and PI(3,4)P2) and less GAP activity toward Arf1 -IFI16 IFI16 Transcription factor Q16666 3428 1q23.1 human K6-ub 964520238 __MGKKYkNIVLLKG protein degradation signaling pathway regulation STING(INDUCES) 31665637 1 2 0 IFI16 degradation inhibits viral DNA-induced IFN-I production -EGFR EGFR EC 2.7.10.1; KINASE; Kinase, protein; Membrane protein, integral; Oncoprotein; Protein kinase, TK; Protein kinase, tyrosine (receptor) P00533 1956 7p11.2 human T678-p 448053 RHIVRKRtLRRLLQE receptor internalization, induced; protein degradation; molecular association, regulation; receptor recycling, induced; enzymatic activity, inhibited; phosphorylation; receptor desensitization, altered; intracellular localization; receptor internalization, altered; protein conformation; receptor recycling, altered carcinogenesis, induced; cell adhesion, induced; cytoskeletal reorganization; signaling pathway regulation GRB2(INDUCES); G-alpha(s)(DISRUPTS); KPNA1(INDUCES); EGFR(INDUCES); SLC5A1(INDUCES); PKCA(NOT_REPORTED); Calmodulin(DISRUPTS) 10816576; 11185568; 12359306; 1556153; 16793002; 17942932; 18037521; 18042729; 1860884; 20692258; 23205726; 3379075; 34155348; 35791809 22 0 0 -ARAP3 ARAP3 GAP; GAP, ARF; Motility/polarity/chemotaxis Q8WWN8 64411 5q31.3 human Y1408-p 454958 PVYEEPVyEEVGAFP molecular association, regulation carcinogenesis, altered; cell motility, altered; cell adhesion, altered VAV2(INDUCES); TARP(INDUCES) 21076469; 22750419 3 1 3 suppresses peritoneal dissemination of scirrhous gastric carcinoma cells -FOXP3 FOXP3 C2H2-type zinc finger protein; Cell cycle regulation; DNA-binding; Transcription factor Q9BZS1 50943 Xp11.23 human K31-ac 25614402 PSWRAAPkASDLLGA protein stabilization 23644046 2 1 0 -Fyn Fyn EC 2.7.10.2; KINASE; Kinase, protein; Oncoprotein; Protein kinase, TK; Protein kinase, tyrosine (non-receptor) Q62844 25150 20q12 rat Y420-p 447882 RLIEDNEyTARQGAK PK_Tyr_Ser-Thr enzymatic activity, induced 19625508 31 94 3048 -Rcan1 RCAN1 Inhibitor Q9JHG6 54720 16 C4|16 53.6 cM mouse T206-p 21511700 LHAATDTtPSVVVHV Calcipressin molecular association, regulation PPP3CA(DISRUPTS) 22864830 2 1 0 -MCRS1 MCRS1 Nuclear receptor co-regulator; Nucleolus; RNA-binding Q96EZ8 10445 12q13.12 human S35-p 14575930 LAGQKRAsSQALGTI cell cycle regulation; cytoskeletal reorganization 27192185 1 3 1 K-fiber formation and dynamics -Ms4a2 FcER1B Membrane protein, integral; Membrane protein, multi-pass; Receptor, misc. P13386 25316 1q43 rat Y224-p 2883703 LYEELHVySPIYSAL molecular association, regulation GRB2(INDUCES); SHIP(INDUCES); Syk(INDUCES); SHC1(INDUCES); SHP-1(INDUCES) 17365510 1 1 0 SHIP binding is senstive to the presence of Syk. -SMAD3 SMAD3 DNA-binding; Nuclear receptor co-regulator; Transcription factor P84022 4088 15q22.33 human S418-p 6845003 LTQMGSPsIRCSSVS protein degradation; ubiquitination; intracellular localization; activity, inhibited cell growth, inhibited; signaling pathway regulation 18760948; 18794808 2 1 0 nuclear translocation; destabilizes the activated Smad3 and inhibits TGF-beta signaling -SOX2 SOX2 Cell development/differentiation; DNA-binding; Transcription factor P48431 6657 3q26.33 human T116-p 17490601 KYRPRRKtKTLMKKD SOXp protein degradation; protein stabilization UBR5(DISRUPTS) 30894683 2 0 0 AKT1 phosphorylation at T116 blocks UBR5-induced ubiquitination at K115 of SOX2; AKT protects SOX2 from UBR5, TRIM3, and CUL9-mediated degradation -RARA RARA DNA-binding; Nuclear receptor; Oncoprotein; Transcription factor P10276 5914 17q21.2 human S369-p 451381 YVRKRRPsRPHMFPK Hormone_recep protein degradation; acetylation; molecular association, regulation; intracellular localization; activity, inhibited; protein conformation; phosphorylation chromatin organization, altered; cell differentiation, induced; transcription, induced; transcription, inhibited; signaling pathway regulation SMRT(DISRUPTS); RARA iso2(INDUCES); CCNH(INDUCES); RXRA(DISRUPTS); GTF2H1(INDUCES) DNA(INDUCES) 16769902; 19078967; 20215566; 23382200; 23637584; 27419624 8 0 0 -PTPN7 HePTP EC 3.1.3.48; Motility/polarity/chemotaxis; PHOSPHATASE; Protein phosphatase, tyrosine (non-receptor) P35236 5778 1q32.1 human S93-p 448310 ALQRQPPsPKQLEEE molecular association, regulation; protein conformation ERK2(DISRUPTS); P38A(DISRUPTS) 10206983; 16226275 3 9 1 -H3c1 H3 DNA-binding P68433 360198 13|13 A3.1 mouse S10-p 455676 TKQTARKsTGGKAPR Histone molecular association, regulation chromatin organization, altered; transcription, induced; transcription, inhibited; transcription, altered; cell growth, altered 14-3-3 zeta(INDUCES); 14-3-3 epsilon(INDUCES); CBX4(DISRUPTS); CBX1(DISRUPTS); CBX3(DISRUPTS); HP1 alpha(DISRUPTS); CBX8(DISRUPTS); CBX7(DISRUPTS); CBX1(INDUCES) DNA(INDUCES) 10899125; 11242053; 16222246; 17590163; 18381464; 19109180; 19264835; 19859561; 19965984; 20067909; 20129940; 24430871; 26051938; 33761914 241 15 1 -ABL2 Arg EC 2.7.10.2; KINASE; Kinase, protein; Oncoprotein; Protein kinase, TK; Protein kinase, tyrosine (non-receptor) P42684 27 1q25.2 human Y439-p 447923 RLMTGDTyTAHAGAK PK_Tyr_Ser-Thr protein degradation 15735735 4 39 1640 -RB1CC1 RB1CC1 Autophagy; DNA-binding; Transcription factor; Tumor suppressor Q8TDY2 9821 8q11.23 human K276-ac 1883544403 TADAESGkEIRESCQ protein stabilization 36394358 1 1 0 Puncta formation of RB1CC1, autophagosome formation -Trpc6 TRPC6 Channel, cation; Membrane protein, integral; Membrane protein, multi-pass Q61143 22068 9 A1|9 2.46 cM mouse S448-p 15794302 KFVAHAAsFTIFLGL TM; Ion_trans activity, inhibited 20961851 1 0 0 -Ptprh PTPRH EC 3.1.3.48; Membrane protein, integral; Motility/polarity/chemotaxis; PHOSPHATASE; Receptor protein phosphatase, tyrosine E9Q0N2 545902 7|7 A1 mouse Y945-p 14312603 LVPEEAMyENVASLV molecular association, regulation cytoskeletal reorganization GRB2(INDUCES); Fyn(INDUCES) 20398064 1 0 0 -TNNI3 TNNI3 Actin-binding; Motility/polarity/chemotaxis; Motor P19429 7137 19q13.42 human S166-p 3146609 LGARAKEsLDLRAHL Troponin molecular association, regulation TNNC1(DISRUPTS) 11121119 1 3 0 -EIF1 EIF1 Translation; Translation initiation P41567 10209 17q21.2 human T72-p 34404300 KKFACNGtVIEHPEY SUI1 translation, induced 24898249 1 1 0 ZFAND2A translation -RECQL4 RECQL4 EC 3.6.4.12; Helicase O94761 9401 8q24.3 human K382-ac 7106305 RKQAWKQkWRKKGEC intracellular localization 19299466 1 0 0 accumulates in the cytoplasm -HSPA5 GRP78 Chaperone; Heat shock protein; KINASE P11021 3309 9q33.3 human K633-ac 13362605 IVQPIISkLYGSAGP HSP70 molecular association, regulation; phosphorylation apoptosis, induced; signaling pathway regulation PERK(DISRUPTS) 20371724 1 1 0 induces phosphorylation of elf2a and activation of eIf2a-ATF4-CHOP pathway -Creb1 CREB iso1 DNA-binding; Transcription factor Q01147-1 12912 mouse K304-sm 12063904 ARECRRKkKEYVKCL bZIP_1 cell differentiation, inhibited; transcription, induced 31433978 2 0 0 -KCNQ4 KCNQ4 Membrane protein, integral; Membrane protein, multi-pass P56696 9132 1p34.2 human T552-p 13301700 AKRKFKEtLRPYDVK KCNQ_channel activity, inhibited 20147557 1 0 0 mediates AKAP79 sensitization to inhibition by muscarinic receptor stimulation -Oprm1 MOR-1 GPCR, family 1; Membrane protein, integral; Membrane protein, multi-pass; Receptor, GPCR P33535 25601 1q11 rat Y166-p 455805 CTMSVDRyIAVCHPV 7tm_1 activity, inhibited 11353794; 19959593 3 0 0 reduces G-protein coupling efficiency of the mu opioid receptor -ATF4 ATF-4 DNA-binding; Transcription factor P18848 468 22q13.1 human T115-p 40420008 MPDDLLTtLDDTCDL protein degradation transcription, inhibited 25795775 1 1 0 -PRDM16 PRDM16 iso4 C2H2-type zinc finger protein; Methyltransferase, protein lysine, predicted Q9HAZ2-4 63976 1p36.32 human K568-sm 25087003 LAHNLLVkAEPKSPR molecular association, regulation cell differentiation, inhibited; carcinogenesis, induced; cell growth, induced; cell differentiation, induced; transcription, altered; transcription, inhibited HDAC2(INDUCES) 21516122; 26559765 2 0 0 -GIT2 GIT2 GAP; GAP, ARF; Motility/polarity/chemotaxis Q14161 9815 12q24.11 human S384-p 30999681 NNQHSVEsQDNDQPD molecular association, regulation; intracellular localization DNA repair, induced MDC1(INDUCES); H2AX(INDUCES); NBS1(INDUCES); PARP1(INDUCES) 25605334 1 3 0 nuclear foci formation -Tfcp2l1 TFCP2L1 DNA-binding Q3UNW5 81879 1|1 E2.3 mouse S397-p 1875342304 QDDSGDNsLCVYHAI protein degradation; molecular association, regulation; ubiquitination; intracellular localization cell differentiation, induced BTRC(INDUCES) 34731635 1 0 0 -Cry1 CRY1 DNA-binding; Lyase; Transcription, coactivator/corepressor P97784 12952 10 C1|10 41.63 cM mouse S280-p 11952907 YKKVKKNsSPPLSLY protein degradation; molecular association, regulation PER2(INDUCES); FBXL3(INDUCES) 19833968 1 0 0 -Smpd3 SMPD3 EC 3.1.4.12; Lipid Metabolism - sphingolipid; Membrane protein, integral; Phospholipase Q9JJY3 58994 8|8 D3 mouse S292-p 4780079 GDSGSLGsPSASRES protein stabilization; enzymatic activity, induced 22074919 1 9 4 -Musk MUSK EC 2.7.10.1; KINASE; Kinase, protein; Membrane protein, integral; Protein kinase, TK; Protein kinase, tyrosine (receptor) Q62838 rat Y754-p 2848302 RNIYSADyYKADGND PK_Tyr_Ser-Thr phosphorylation; enzymatic activity, induced 10619845 1 3 0 promotes MuSK phosphorylation; promotes AChRb clustering and phosphorylation -RACGAP1 MgcRacGAP GAP; GAP, Rac/Rho Q9H0H5 29127 12q13.12 human S164-p 459864 SFDKTDEsLDWDSSL molecular association, regulation; enzymatic activity, induced cell cycle regulation; cytoskeletal reorganization ECT2(INDUCES) 25486482; 35477750 3 5 0 induces Rho GTPase activity; restrain ectopic or premature cytokinesis onset -Fcrl1 FCRL1 Membrane protein, integral Q8R4Y0 229499 3|3 F1 mouse Y297-p 1874990000 NEVYSLVyHTPQVLE phosphorylation 34697226 1 1 0 inhibits ERK phosphorylation -STX1A STX1A Membrane protein, integral; Vesicle Q16623 6804 7q11.23 human S14-p 451261 ELRTAKDsDDDDDVA activity, induced; molecular association, regulation; protein conformation exocytosis, altered; exocytosis, induced DAT(INDUCES); STXBP1(DISRUPTS) 19748891; 25774383; 34948351 7 22 4 -PNPLA2 PNPLA2 EC 3.1.1.3; Lipase; Membrane protein, integral Q96AD5 57104 11p15.5 human K100-ub 21181820 IIRSFLLkVLPADSH Patatin protein degradation 27658392 1 2 0 regulation of hepatic lipid metabolism -Prkci PKCI Cell adhesion; Cell development/differentiation; EC 2.7.11.13; KINASE; Kinase, protein; Motility/polarity/chemotaxis; Oncoprotein; Protein kinase, AGC; Protein kinase, Ser/Thr (non-receptor); Tumor suppressor F1M7Y5 84006 2q24 rat Y265-p 450076 RVIGRGSyAKVLLVR Pkinase intracellular localization KPNB1(INDUCES) 11891849 2 0 0 -Lpp LPP Adaptor/scaffold; Cytoskeletal; Motility/polarity/chemotaxis Q8BFW7 210126 16|16 B1 mouse Y333-p 463381 TWKREAAyAPPASGN cell cycle regulation; cell motility, altered 18515860 0 4 21 -EPS8 EPS8 Adaptor/scaffold Q12929 2059 12p12.3 human Y774-p 457814 CPEGARVySQITVQK SAM_3 cell cycle regulation; cell motility, induced 32641864 2 10 283 -Rreb1 RREB1 C2H2-type zinc finger protein; DNA-binding; Motility/polarity/chemotaxis; Nuclear receptor co-regulator; Transcription, coactivator/corepressor Q3UH06 68750 13|13 A3.3 mouse S161-p 4719122 TTAAAPPsPLKRRRL molecular association, regulation transcription, induced DNA(INDUCES) 31915377 1 35 6 -Ffar4 GPR120 GPCR, family 1; Lipid-binding; Membrane protein, integral; Membrane protein, multi-pass; Receptor, GPCR Q7TMA4 107221 19|19 C2 mouse T347-p 31014807 PEKGAIFtDTSVRRN receptor internalization, induced; molecular association, regulation ARR3(INDUCES) 26873857; 32817367 5 1 0 -Map3k7 TAK1 iso3 EC 2.7.11.25; KINASE; Kinase, protein; Protein kinase, Ser/Thr (non-receptor); Protein kinase, TKL Q923A8 26409 4|4 A5 mouse T187-p 454704 CDIQTHMtNNKGSAA PK_Tyr_Ser-Thr activity, induced; molecular association, regulation apoptosis, induced; signaling pathway regulation TAB2(INDUCES); TRAF6(INDUCES) 30626936 33 1 0 Phosphorylation of JNK, p38 and IkB (subsequent degradation) -Tsc2 TSC2 iso2 Cell cycle regulation; GAP; GAP, misc.; Nuclear receptor co-regulator; Tumor suppressor P49816-2 24855 10q12 rat S1338-p 450215 VDLSFQPsQPLSKSS phosphorylation apoptosis, altered; cell growth, altered 14651849 2 0 1 -Tp53 p53 Activator; DNA-binding; Motility/polarity/chemotaxis; Nuclear receptor co-regulator; Transcription factor; Tumor suppressor P02340 22059 11 B3|11 42.83 cM mouse K317-ac 458976 SASPPQKkKPLDGEY P53_tetramer apoptosis, altered; cell growth, inhibited; apoptosis, induced; transcription, induced; signaling pathway regulation; transcription, altered; translation, altered; apoptosis, inhibited 10990460; 16943427; 18178582; 35534985 56 2 0 HDAC6 ablation induces senescence p21 expression and inhibits cell growth, HDAC6 ablation inhibits HC proliferation after two-thirds partial hepatectomy (PHx); regulates TNF-alpha signaling, p53 K317R mutation affects the response to IR of many proteins; negatively regulates p53 apoptotic activities after DNA damage -STAT5B STAT5B DNA-binding; Oncoprotein; Transcription factor P51692 6777 17q21.2 human S193-p 483615 FGPLAQLsPQERLSR STAT_alpha molecular association, regulation transcription, induced DNA(INDUCES) 22442148 2 18 1 -TRIM14 TRIM14 Transcription regulation Q14142 9830 9q22.33 human K365-ub 27213241 NRQSWCLkRYDLEYW SPRY molecular association, regulation; intracellular localization IKKG(INDUCES) 24379373 1 1 0 assembly of the MAVS signalosome, recruitment of IKKG, IFN activation, and NFkB activation -PTEN PTEN Carbohydrate Metabolism - inositol phosphate; EC 3.1.3.16; EC 3.1.3.48; EC 3.1.3.67; Motility/polarity/chemotaxis; Nuclear receptor co-regulator; PHOSPHATASE; Phosphatase, lipid; Tumor suppressor P60484 5728 10q23.31 human Y27-p 34668100 GFDLDLTyIYPNIIA activity, inhibited 23995781 1 0 0 PTEN downregulation -TH TH Amino Acid Metabolism - tyrosine; EC 1.14.16.2; Endoplasmic reticulum; Mitochondrial; Oxidoreductase; Vesicle P07101 7054 11p15.5 human S62-p 448544 SYTPTPRsPRFIGRR TOH_N enzymatic activity, induced 7901013 43 8 0 -LOC100125989 TPM1 Actin-binding; Motility/polarity/chemotaxis; Motor P58772 rabbit S283-p 451804 HALNDMTsI______ Tropomyosin molecular association, regulation cytoskeletal reorganization TPM1(INDUCES) 10833280 11 15 94 sedimentation and viscometry methods have been used to describe the head-to-tail interaction of TPM1 protein -MAFG MAFG Cell cycle regulation; DNA-binding O15525 4097 17q25.3 human K76-ac 458967 RVKRVTQkEELEKQK bZIP_Maf molecular association, regulation DNA(INDUCES) 11154691 1 0 0 -FEN1 FEN1 DNA repair, damage; DNA-binding; Deoxyribonuclease; EC 3.1.-.-; Nuclear receptor co-regulator; Nucleolus; Ribonuclease P39748 2237 11q12.2 human K377-me 1873037704 TGAAGKFkRGK____ molecular association, regulation DNA repair, induced DNA(DISRUPTS) 28611278 1 1 0 essential for cell survival to replicative stress -SCML2 SCML2 Transcription factor Q9UQR0 10389 Xp22.13 human K123-m1 58123404 QPVGTCEkEGDLLQP MBT molecular association, regulation L3MBTL iso4(INDUCES) 23583077 0 1 0 -Syt12 SYT12 Membrane protein, integral; Vesicle P97610 191595 1q43 rat S97-p 473040 GPPSRKGsLSIEDTF exocytosis, altered 17190793 2 2 0 increases spontaneous neurotransmitter release -Plin1 perilipin 1 Lipid-binding Q8CGN5 103968 7|7 D2 mouse S81-p 450079 EPVVRRLsTQFTAAN Perilipin molecular association, regulation HSL(INDUCES) 19717842 2 8 15 -H4-16 H4 DNA-binding NP_001139343 530773 cow K5-ac 458958 ___SGRGkGGKGLGK methylation cell cycle regulation 18698155 72 22 516 complex relationship of acetylation and methylation of CpG dinucleotides on DNA, during development of gametogenesis and embryogenesis -FUS hnRNP P2 DNA-binding; Nuclear receptor co-regulator; Oncoprotein; RNA splicing; RNA-binding; SUMO LIGASE P35637 2521 16p11.2 human K316-ac 1877549401 GIIKTNKkTGQPMIN RRM_1 molecular association, regulation RNA(DISRUPTS) 32691043 1 1 0 -Ddx46 DDX46 EC 3.6.4.13; Helicase; Spliceosome Q569Z5 212880 13|13 B1 mouse K470-ac 206219705 KECKKFSkTLGLRVV DEAD molecular association, regulation ALKBH5(INDUCES) 28846086 1 0 0 K470R lost its binding to ALKBH5, while other positions did not -kif2c KIF2C Cancer Testis Antigen (CTA); Microtubule-binding; Motility/polarity/chemotaxis; Motor Q91636 380006 frog S110-p 2132101 KEVAAKNsLLSESGA molecular association, regulation; intracellular localization cytoskeletal reorganization DNA(INDUCES) 17567953 1 0 0 -Crebbp CBP ACETYLTRANSFERASE; Acetyltransferase; DNA-binding; EC 2.3.1.48; Motility/polarity/chemotaxis; Nuclear receptor co-regulator; Transcription, coactivator/corepressor P45481 12914 16 A1|16 2.4 cM mouse R600-me 478320 EHVTQDLrSHLVHKL KIX molecular association, regulation CREB(DISRUPTS) 11701890 2 0 0 -XRCC5 Ku80 DNA-binding; EC 3.6.1.-; EC 3.6.4.-; Helicase; Nuclear receptor co-regulator; Nucleolus; RNA-binding P13010 7520 2q35 human K144-ub 10844844 DLSSRFSkSQLDIII Ku_N molecular association, regulation DNA repair, induced DNA(DISRUPTS) 27895153 1 6 24 -BCL2L11 BIM Apoptosis O43521 10018 2q13 human S98-p 8080218 RSSSGYFsFDTDRSP protein degradation; molecular association, regulation; ubiquitination BTRC(INDUCES) 23912711 1 0 0 -UVRAG UVRAG Autophagy Q9P2Y5 7405 11q13.5 human S498-p 1222327 GFSGGIPsPDKGHRK protein stabilization; molecular association, regulation carcinogenesis, induced; cell growth, induced; autophagy, inhibited rubicon(INDUCES) 25533187 2 38 26 interaction with RUBICON supressed Vsp34 kinase activity, endosome-lysosomal degradation of EGFR induced -Hck Hck EC 2.7.10.2; KINASE; Kinase, protein; Oncoprotein; Protein kinase, TK; Protein kinase, tyrosine (non-receptor) P08103 15162 2 H1|2 75.41 cM mouse Y409-p 448168 RIIEDNEyTAREGAK PK_Tyr_Ser-Thr phosphorylation; enzymatic activity, induced 10934191; 27531930 13 70 2093 phosphorylation of PKCD -ZNF282 ZNF282 C2H2-type zinc finger protein Q9UDV7 8427 7q36.1 human K293-sm 31094513 QDASSQVkREDTLCV molecular association, regulation carcinogenesis, induced; transcription, induced CALCOCO1(INDUCES); ER-alpha(INDUCES) 22986521 1 0 0 -HIF1A HIF1A Autophagy; DNA-binding; Transcription factor Q16665 3091 14q23.2 human S696-p 17595900 NVLSVALsQRTTVPE protein stabilization transcription, altered 21095582 2 1 0 required for the hypoxic regulation of the mTOR pathway -Nsfl1c NSFL1C Vesicle Q9CZ44 386649 2|2 G3 mouse S176-p 468328 AGERRRHsGQDVHVV activity, induced cell growth, induced 30783609 1 37 9 Induce/promote dendritic cell growth and dentritic arborization -MTF1 MTF1 C2H2-type zinc finger protein; Transcription factor Q14872 4520 1p34.3 human S152-p 50784002 EGCPRTYsTAGNLRT zf-C2H2 activity, inhibited apoptosis, induced; transcription, inhibited 35027733 1 3 0 -RHO Rhodopsin GPCR, family 1; Membrane protein, integral; Membrane protein, multi-pass; Receptor, GPCR P02699 509933 cow S334-p 448677 PLGDDEAsTTVSKTE molecular association, regulation; protein conformation SAG(INDUCES) 15041682 8 6 0 Computational and in vitro data. S343 may be a weaker interaction. -SOS1 SOS1 Adaptor/scaffold; GEF; GEF, Ras; Motility/polarity/chemotaxis Q07889 6654 2p22.1 human S1134-p 483244 PHGPRSAsVSSISLT molecular association, regulation signaling pathway regulation 14-3-3 epsilon(INDUCES) 22827337 1 31 3 -CDC25A CDC25A EC 3.1.3.48; Motility/polarity/chemotaxis; PHOSPHATASE; Protein phosphatase, dual-specificity P30304 993 3p21.31 human S116-p 449977 PQKLLGCsPALKRSH M-inducer_phosp protein stabilization cell cycle regulation CDK1(INDUCES) 12411508 2 7 0 -PTH PTH Apoptosis; Hormone; Secreted; Secreted, signal peptide P01270 5741 11p15.3 human S48-p 25750949 NLGKHLNsMERVEWL Parathyroid molecular association, regulation signaling pathway regulation PTHR(INDUCES) 25158085 1 1 1 -App APP Apoptosis; Cell surface; Membrane protein, integral; Receptor, misc.; Transcription factor P12023 11820 16 C3.3|16 46.92 cM mouse S679-p 480465 DAEFGHDsGFEVRHQ Beta-APP molecular association, regulation; protein conformation 21527912; 27400251 9 2 0 increases the number of binding proteins; aggregation by promotion of beta-sheet conformation, increased toxicity, degeneration of eyes induced and AB accumulation in Drosophila -CEBPA C/EBP-alpha DNA-binding; Transcription factor P49715 1050 19q13.11 human R165-m1 1878324502 LVIKQEPrEEDEAKQ cell cycle regulation; carcinogenesis, induced; cell growth, induced; transcription, inhibited HDAC3(DISRUPTS) 31015230 1 1 0 -PACS2 PACS2 Q86VP3 23241 14q32.33 human S213-p 1884003504 FSSEQEAsDDAVQGQ intracellular localization 37523531 1 0 0 -ZFP36L1 BRF1 Transcription factor Q07352 677 14q24.1 human S54-p 2475300 GGFPRRHsVTLPSSK Tis11B_N activity, induced; protein stabilization; molecular association, regulation cell growth, inhibited; transcription, altered 14-3-3 beta(INDUCES) 18326031; 26280535; 27708140 3 37 13 inhibits BRF1-dependent AMD ( ARE-mediated mRNA decay); senescence-associated secretory phenotype (SASP) -SNAI1 Snail1 C2H2-type zinc finger protein; Transcription factor O95863 6615 20q13.13 human S246-p 455616 QACARTFsRMSLLHK intracellular localization carcinogenesis, induced; transcription, inhibited; transcription, altered 15833848; 25125660; 28423359 3 0 0 nuclear accumulation -MYL12A MRLC3 Contractile P19105 10627 18p11.31 human S19-p 7382102 KRPQRATsNVFAMFD molecular association, regulation; protein conformation; enzymatic activity, induced cell cycle regulation; exocytosis, induced; cytoskeletal reorganization MRLC3(DISRUPTS) 10944522; 12446732; 15069078; 15753305; 8530442; 9651368; 9786863 16 60 246 -HIF1A HIF1A Autophagy; DNA-binding; Transcription factor Q16665 3091 14q23.2 human S551-p 34494910 TEAKNPFsTQDTDLD HIF-1 protein degradation cell growth, inhibited; cell motility, inhibited; signaling pathway regulation 30254159 1 0 0 PI3K pathway and AKT are strongly activated by IRIS -SET SET Apoptosis; DNA replication; DNA-binding; Inhibitor; Nuclear receptor co-regulator; Oncoprotein; Protein phosphatase, regulatory subunit Q01105 6418 9q34.11 human K150-ub 3935287 ENPYFENkVLSKEFH NAP protein degradation 35843886 1 8 35 -GAB1 GAB1 Adaptor/scaffold; Motility/polarity/chemotaxis Q13480 2549 4q31.21 human Y659-p 447949 VADERVDyVVVDQQK molecular association, regulation cell cycle regulation; carcinogenesis, induced; cell motility, induced SHP-2(INDUCES) 11323411; 34731623 9 49 1482 -KRAS KRas iso2 G protein; G protein, monomeric; G protein, monomeric, Ras; Motility/polarity/chemotaxis; Oncoprotein P01116-2 3845 12p12.1 human K104-ub 31914116 REQIKRVkDSEDVPM Ras protein conformation 33929846 2 0 0 preferred configurations/conformations while sampling a large conformational space, K104 has a minimal effect on RBD or CRD recognition. ubiquitination at K104, but not K147, potentially affects both membrane reorientation and dimerization of KRAS -TCF3 E2A Cell development/differentiation; DNA-binding; Oncoprotein; Transcription factor P15923 6929 19p13.3 human S139-p 455905 LNSPGPLsPSGMKGT transcription, induced; cell growth, altered 11114297; 31540485 3 9 0 POSTN expression -RTKN RTKN iso2 G protein regulator, misc. Q9BST9-2 6242 2p13.1 human S435-p 15423057 QALAKQGsLYHEMAI enzymatic activity, induced cytoskeletal reorganization 22228765 1 5 1 RhoA activity induced; enhances actin stress fibre formation -PTPRJ PTPRJ EC 3.1.3.48; Membrane protein, integral; Motility/polarity/chemotaxis; PHOSPHATASE; Receptor protein phosphatase, tyrosine Q12913 5795 11p11.2 human Y1311-p 473909 DSKVDLIyQNTTAMT molecular association, regulation; enzymatic activity, induced cell motility, induced Src(INDUCES) 22898603 1 2 13 -CLIP1 Restin Cytoskeletal P30622 6249 12q24.31 human T287-p 483203 KIGFPSTtPAKAKAN molecular association, regulation; intracellular localization cell cycle regulation PLK1(INDUCES) 24777477 3 6 3 PLK1 recruitment to kinetochores, kinetochore localization of CENP-E, kinetochore-fiber stability, chromosome alignment -TP63 p63 DNA-binding; Transcription factor Q9H3D4 8626 3q28 human Y149-p 452168 SVTAPSPyAQPSSTF protein stabilization transcription, altered 19783996 1 0 0 -PSTPIP2 PSTPIP2 Actin-binding Q9H939 9050 18q21.1|tdb7990 human Y323-p 449698 SSPDDPNySLVDDYS molecular association, regulation SHIP(INDUCES) 26304991 1 3 4 -MAPRE1 EB1 Cytoskeletal; Motility/polarity/chemotaxis Q15691 22919 20q11.21 human S156-p 1259758900 PKKPLTSsSAAPQRP intracellular localization carcinogenesis, inhibited; cytoskeletal reorganization; cell motility, inhibited; signaling pathway regulation 30250248 1 0 0 enhances cytotoxicity -AANAT AA-NAT ACETYLTRANSFERASE; Acetyltransferase; Amino Acid Metabolism - tryptophan; EC 2.3.1.87 Q29495 443531 sheep S205-p 452142 HAALRRNsDR_____ protein stabilization; molecular association, regulation; enzymatic activity, inhibited 14-3-3 beta(INDUCES); 14-3-3 zeta(INDUCES) 15632116; 15644438; 18771288 3 0 1 -BSG BSG iso2 Immunoglobulin superfamily; Membrane protein, integral P35613-2 682 19p13.3 human Y183-p 38486780 MEADPGQyRCNGTSS Ig_3 molecular association, regulation carcinogenesis, induced; cell motility, induced MGAT5(INDUCES) 32291412 1 2 0 induce MMP-9 expression -TYK2 Tyk2 EC 2.7.10.2; KINASE; Kinase, protein; Protein kinase, TK; Protein kinase, tyrosine (non-receptor) P29597 7297 19p13.2 human Y1054-p 447499 AVPEGHEyYRVREDG PK_Tyr_Ser-Thr enzymatic activity, induced signaling pathway regulation 31341059; 8702790 9 2 59 -PPARG PPAR-gamma DNA-binding; Nuclear receptor; Transcription factor P37231 5468 3p25.2 human K184-ub 40190201 DLNCRIHkKSRNKCQ zf-C4 protein degradation; intracellular localization cell differentiation, inhibited 24336050 1 0 0 -GRIN2B NMDAR2B Channel, calcium; Channel, ligand-gated; Membrane protein, integral; Membrane protein, multi-pass Q13224 2904 12p13.1 human S1323-p 455808 ALAPRSVsLKDKGRF NMDAR2_C activity, induced 22179603 5 2 1 Phosphorylation increased receptor mechanosensitivity-neuronal stretch sensitivity -GABBR1 GABBR1 GPCR, family 3; Membrane protein, integral; Membrane protein, multi-pass; Receptor, GPCR Q9UBS5 2550 6p22.1 human K900-ub 54191601 KENRELEkIIAEKEE protein degradation; ubiquitination 26817839 1 0 0 -AMOTL2 AMOTL2 Cell adhesion Q9Y2J4 51421 3q22.2 human S159-p 29674704 HGHVRSLsERLLQLS phosphorylation 24225952 1 4 0 YAP phosphorylation -Lrrk1 LRRK1 EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, Ser/Thr (non-receptor); Protein kinase, TKL Q3UHC2 233328 7|7 C mouse Y1430-p 460480 GVEGTPGyQAPEIRP Pkinase enzymatic activity, induced 20697350 0 1 8 -CDC5L CDC5L DNA-binding; Motility/polarity/chemotaxis; RNA processing; RNA splicing; Spliceosome; Transcription factor Q99459 988 6p21.1 human T411-p 469436 TPNTVLStPFRTPSN Myb_Cef RNA splicing, altered 18583928 1 4 32 -Kcnj1 ROMK iso2 Channel, potassium; Membrane protein, integral; Membrane protein, multi-pass P35560-2 rat S200-p 2461201 RVANLRKsLLIGSHI IRK_C activity, induced 8621594 5 0 0 phosphorylation of at least two serines necessary for channel activity -Slc12a5 KCC2 iso2 Membrane protein, integral; Membrane protein, multi-pass; Transporter; Transporter, SLC family Q91V14-2 57138 2|2 H3 mouse T906-p 10045603 SAYTYEKtLVMEQRS SLC12 activity, inhibited neural plasticity 27025876; 31396048 7 4 0 regulates hyperpolarizing synaptic inhibition and adulthood cognitive function -CACB CACNA1C Channel, calcium; Membrane protein, integral; Membrane protein, multi-pass P15381 100101555 rabbit S1575-p 467228 VACKRLVsMNMPLNS GPHH activity, induced 16820363 4 0 0 -Ccnb1 CCNB1 Activator; Cell cycle regulation P24860 268697 13 D1|13 53.23 cM mouse S123-p 448814 PILVDNPsPSPMETS cytoskeletal reorganization 25349079 11 2 0 promotes meiotic resumption -SIK2 QIK EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, CAMK; Protein kinase, Ser/Thr (non-receptor) Q9H0K1 23235 11q23.1 human K53-ac 27581523 VAIKIIDkSQLDAVN Pkinase intracellular localization; enzymatic activity, inhibited; phosphorylation autophagy, induced 23322770 1 1 0 inhibits autophosphorylation of QIK, promotes aggresome removal -Tmod1 TMOD1 Cell development/differentiation; Contractile; Cytoskeletal; Motility/polarity/chemotaxis P49813 21916 4 B1|4 24.49 cM mouse T54-p 22561900 GLRQKDQtTKAPTGP Tropomodulin cytoskeletal reorganization 24891520 2 0 0 pointed-end assembly and thin filament length regulatory function -GHR GH receptor Membrane protein, integral; Receptor, cytokine NP_999419 397488 pig Y566-p 486257 SFNQEDIyITTESLT GHBP transcription, induced DNA(INDUCES) 8647880 3 0 0 -PHLPP1 PHLPP EC 3.1.3.16; PHOSPHATASE; Protein phosphatase, Ser/Thr (non-receptor); Tumor suppressor O60346 23239 18q21.33 human T409-p 1871700800 QPLPLPQtASSPQPQ cell cycle regulation 33397691 1 1 0 -GRB2 GRB2 Adaptor/scaffold; Cell development/differentiation; Motility/polarity/chemotaxis P62993 2885 17q25.1 human Y52-p 7388002 DGFIPKNyIEMKPHP cell growth, altered 19273609 1 0 1 regulates cell proliferation -Nphs1 NPHS1 Cell adhesion; Immunoglobulin superfamily; Membrane protein, integral Q9R044 64563 1q21 rat Y1152-p 6377604 TAEVDPNyYSMRDFS molecular association, regulation; phosphorylation SHP-1(INDUCES) 25404734 3 0 0 -PPM1B PPM1B EC 3.1.3.16; Motility/polarity/chemotaxis; PHOSPHATASE; Protein phosphatase, Ser/Thr (non-receptor) O75688 5495 2p21 human K326-ub 21182132 RVEEIMEkSGEEGMP PP2C_C ubiquitination; intracellular localization 35176871 1 3 0 Yap inhibits ubiquitination and nuclear translocation ; nuclear translocation -Ptk2 FAK iso2 EC 2.7.10.2; KINASE; Kinase, protein; Protein kinase, TK; Protein kinase, tyrosine (non-receptor) P34152-2 14083 15 D3|15 33.94 cM mouse Y892-p 447965 PTGNQHIyQPVGKPD cell motility, induced; cell growth, induced 21900245 75 21 307 attachment independent FAK phosphorylation requires paxillin -Camk2b CAMK2B EC 2.7.11.17; KINASE; Kinase, protein; Protein kinase, CAMK; Protein kinase, Ser/Thr (non-receptor) P08413 24245 14q21 rat S363-p 3558927 TNSTKNSsAITSPKG molecular association, regulation 26291163 1 6 0 inhibits interaction with F-actin, regulates synaptic plasticity -Ptk2 FAK iso4 EC 2.7.10.2; KINASE; Kinase, protein; Protein kinase, TK; Protein kinase, tyrosine (non-receptor) P34152-4 14083 15 D3|15 33.94 cM mouse Y397-p 447887 SVSETDDyAEIIDEE apoptosis, induced; cytoskeletal reorganization; signaling pathway regulation 30187999 371 31 474 a6?4/FAK/p38 pathway regulation; increased desmin expression; podocyte injury; decreased WT1, synaptopodin expression -Cdh5 CDH5 Cell adhesion; Membrane protein, integral; Motility/polarity/chemotaxis P55284 12562 8 D3|8 53.04 cM mouse Y733-p 2028402 DTLHIYGyEGAESIA CADH_Y-type_LIR cell motility, altered 18096689 1 0 1 affects cell migration and increased endothelial cell barrier permeability -SIRPA SHPS1 Cell adhesion; Cell surface; Membrane protein, integral; Motility/polarity/chemotaxis; Receptor, misc. P78324 140885 20p13 human Y429-p 458557 QDTNDITyADLNLPK molecular association, regulation; phosphorylation cell motility, induced; cell growth, induced; signaling pathway regulation SHP-2(INDUCES); SHP-1(INDUCES) 10842184; 18233962; 21799000 3 12 49 regulation TLR3/4-dependent cytokine production pathway; induces phosphorylation of MAPK, regulates SHPS-1 signaling; Mutation of these 4 tyrosines does not affect JAK2 binding. However, overexpression of the WT SHPS1 but not the 4 tyrosine to phenylalanine mutation reduces tyrosine phosphorylation of Jak2, STAT5B, and STAT3 and activation of Erk1/2 in response to growth hormone. Does not affect STAT3 tyrosine phosphorylation in response to LIF agonist. -LIMD1 LIMD1 Motility/polarity/chemotaxis; Tumor suppressor Q9UGP4 8994 3p21.31 human S421-p 3214989 LGSVLLDsPSSPRVR cell cycle regulation; carcinogenesis, inhibited; cell growth, inhibited; cell motility, inhibited 30600590 1 21 0 mitotic phosphorylation required for mitotic progression -Gsc GSC DNA-binding; Transcription factor Q02591 14836 12 E|12 54.32 cM mouse K209-sm 2887202 EKVEVWFkNRRAKWR Homeodomain transcription, inhibited 18336814 1 0 0 SUMO modification inhibition is promoter specific -Npy1r NPY1R GPCR, family 1; Membrane protein, integral; Membrane protein, multi-pass; Receptor, GPCR P21555 29358 16p14 rat S375-p 2815305 PVAFKKIsMNDNEKI receptor internalization, altered 15576634 1 2 0 may be an artifact of the truncation mutants -EPHA3 EphA3 EC 2.7.10.1; KINASE; Kinase, protein; Membrane protein, integral; Protein kinase, TK; Protein kinase, tyrosine (receptor) P29320 2042 3p11.1 human Y742-p 25290781 KYLSDMGyVHRDLAA PK_Tyr_Ser-Thr protein conformation; enzymatic activity, induced 18547520 1 1 1 -CELF1 CELF1 Cell development/differentiation; RNA processing; RNA-binding Q92879 10658 11p11.2 human T173-p 29668007 KAMHQAQtMEGCSSP RRM_1 RNA splicing, altered 24151077 1 2 0 splicing regulation in diabetes -Nfatc2 NFAT1 DNA-binding; Transcription factor Q60591 18019 2 H3|2 88.91 cM mouse S278-p 447851 PQRSRSPsPQPSPHV transcription, inhibited 11030334 0 1 0 -SIAH2 SIAH2 EC 6.3.2.-; EC 6.3.2.19; Ligase; Transcription, coactivator/corepressor; UBIQUITIN LIGASE; Ubiquitin conjugating system; Ubiquitin ligase O43255 6478 3q25.1 human S6-p 25172963 __MSRPSsTGPSANK protein stabilization carcinogenesis, induced; cell motility, induced; cell growth, induced 33536006 1 2 0 -DPYSL3 CRMP-4 Hydrolase Q14195 1809 5q32 human T514-p 458798 TTTPKGGtPAGSARG carcinogenesis, induced 30154149 1 27 16 -PPARG PPAR-gamma DNA-binding; Nuclear receptor; Transcription factor P37231 5468 3p25.2 human K185-ub 40190200 LNCRIHKkSRNKCQY zf-C4 protein degradation; intracellular localization cell differentiation, inhibited 24336050 1 0 0 -ATP2A2 SERCA2 Cell adhesion; EC 3.6.3.8; Endoplasmic reticulum; Hydrolase; Membrane protein, integral; Membrane protein, multi-pass; Transporter; Transporter, ion channel P16615 488 12q24.11 human S663-p 452253 EFDELNPsAQRDACL enzymatic activity, inhibited cell growth, inhibited 37291092 1 69 3 ,regulates Ca2+ homeostasis -TGFBR2 TGFBR2 EC 2.7.11.30; KINASE; Kinase, protein; Membrane protein, integral; Oncoprotein; Protein kinase, Ser/Thr (receptor); Protein kinase, TKL P37173 7048 3p24.1 human Y284-p 479864 KIFPYEEyASWKTEK PK_Tyr_Ser-Thr molecular association, regulation cytoskeletal reorganization; cell growth, altered GRB2(INDUCES); SHC1(INDUCES) 17440088; 18174260 3 0 0 important for TGF beta -induced cell invasion; stimulates cell invasion; important for TGF-beta-mediated activation of p38MAPK -Itgb1 ITGB1 Cell adhesion; Cell surface; Membrane protein, integral; Motility/polarity/chemotaxis; Receptor, misc. P09055 16412 8|8 E2 mouse Y783-p 447710 DTGENPIyKSAVTTV Integrin_b_cyt cell motility, altered; cell adhesion, altered 10891511; 11259684 7 42 1183 -SUZ12 SUZ12 C2H2-type zinc finger protein; Oncoprotein; Transcription factor Q15022 23512 17q11.2 human S539-p 4746706 RPKRTKAsMSEFLES molecular association, regulation; ubiquitination EZH2(DISRUPTS) 25855382 1 4 0 -ATF2 ATF-2 ACETYLTRANSFERASE; C2H2-type zinc finger protein; EC 2.3.1.48; Transcription factor P15336 1386 2q31.1 human S498-p 455783 QIVMAPSsQSQPSGS intracellular localization 15916964 1 0 0 S472/480 are important for ionizing radiation-induced S phase checkpoint control -BECN1 beclin 1 Adaptor/scaffold; Autophagy; Membrane protein, peripheral Q14457 8678 17q21.31 human S337-p 41389909 LVPYGNHsYLESLTD APG6 autophagy, induced 26118643 1 1 0 -Slc22a1 SLC22A1 Membrane protein, integral; Membrane protein, multi-pass; Transporter; Transporter, SLC family Q63089 24904 1q11 rat T550-p 455614 TIYLQVQtGKSSST_ activity, induced 15829703 1 0 0 stimulates ASP+ uptake -DDX5 DDX5 EC 3.6.4.13; Helicase; Nuclear receptor co-regulator; Nucleolus; RNA splicing; RNA-binding; Spliceosome P17844 1655 17q23.3 human K40-ac 11321885 KFGNPGEkLVKKKWN protein stabilization; molecular association, regulation carcinogenesis, induced; transcription, induced HDAC1(INDUCES); HDAC2(INDUCES) 20663877 1 6 9 -DOC2B DOC2B Lipid-binding Q14184 8447 17p13.3 human S34-p 1267669105 IRPIKQIsDYFPRFP intracellular localization 30369065 1 0 0 translocated to the plasma membrane, enhanced glucose uptake -Runx2 AML3 iso5 DNA-binding; Transcription factor Q08775-5 12393 17 B3|17 21.33 cM mouse K225-ub 1873375612 ATYHRAIkVTVDGPR Runt cell differentiation, induced; transcription, induced 28500134 1 0 0 -Atp5po ATP5O EC 3.6.3.14; Energy Metabolism - oxidative phosphorylation; Hydrolase; Mitochondrial Q9DB20 28080 16|16 C4 mouse K162-ac 461458 SELKTVLkSFLSPNQ OSCP enzymatic activity, inhibited 24252090 2 9 66 -G6PD G6PD Carbohydrate Metabolism - pentose phosphate pathway; Cell development/differentiation; EC 1.1.1.49; Other Amino Acids Metabolism - glutathione; Oxidoreductase P11413 2539 Xq28 human Y249-p 462295 GTEGRGGyFDEFGII G6PD_C enzymatic activity, induced carcinogenesis, inhibited; cell growth, inhibited 37491277 1 4 9 -Cap1 CAP1 Actin-binding; Cytoskeletal P40124 12331 4|4 D2.2 mouse S36-p 15719534 CGYGDSPsKGAVPYV CAP_N molecular association, regulation cytoskeletal reorganization; cell motility, inhibited Cofilin-1(INDUCES) 25315833 1 7 6 -SCN1A SCN1A Channel, sodium; Membrane protein, integral; Membrane protein, multi-pass P35498 6323 2q24.3 human T1909-p 1239966002 SYQPITTtLKRKQEE molecular association, regulation Calmodulin(INDUCES) 30142967 1 0 0 -Gab2 GAB2 Adaptor/scaffold Q9Z1S8 14389 7|7 E1 mouse S614-p 12097630 DFQPGSPsPHRKPST molecular association, regulation PIK3R1(DISRUPTS) 28096188 1 0 6 -HIF1A HIF1A Autophagy; DNA-binding; Transcription factor Q16665 3091 14q23.2 human T796-p 451302 ESGLPQLtSYDCEVN HIF-1a_CTAD transcription, induced 11983697 1 0 0 -ARL4A ARL4A G protein, monomeric; G protein, monomeric, ARF; Nucleolus P40617 10124 7p21.3 human S143-p 1877718400 QDLRNSLsLSEIEKL Arf protein stabilization; molecular association, regulation; ubiquitination; intracellular localization cell motility, induced HYPK(INDUCES) 35857868 1 1 0 inhibits ubiquitination -SIRT1 SIRT1 Apoptosis; DEACETYLASE; Deacetylase; EC 3.5.1.-; Nuclear receptor co-regulator Q96EB6 23411 10q21.3 human S732-p 1874020214 EAINEAIsVKQEVTD molecular association, regulation; acetylation; protein conformation; enzymatic activity, induced transcription, induced p53(INDUCES); DBC1(DISRUPTS) 34216621 1 1 0 inhibits PGC-1a deacetylation -TP53 p53 Activator; DNA-binding; Motility/polarity/chemotaxis; Nuclear receptor co-regulator; Transcription factor; Tumor suppressor P04637 7157 17p13.1 human S392-p 447535 FKTEGPDsD______ activity, induced; protein degradation; protein stabilization; molecular association, regulation; ubiquitination; intracellular localization; protein conformation cell cycle regulation; carcinogenesis, induced; apoptosis, altered; carcinogenesis, inhibited; cell growth, inhibited; apoptosis, induced; transcription, induced; transcription, altered; transcription, inhibited S100B(DISRUPTS); UBE4B(INDUCES); S100A2(DISRUPTS); p21Cip1(INDUCES); SMAD3(INDUCES); MDM2(DISRUPTS); MDC1(INDUCES); CDK1(DISRUPTS); NFkB-p65(INDUCES) DNA(INDUCES) 10656682; 11239457; 15155458; 15471885; 16651424; 17108107; 17237827; 17891183; 18523266; 18778462; 19819244; 20024960; 21317932; 21423215; 21832239; 22975381; 24194938; 25767119; 26673821; 28937686; 32093423; 32181328; 34103685; 34209868; 34216619; 34282274; 34711610; 34798143; 34980600; 36243702; 9254608; 9315650; 9467949 118 15 0 -ETS1 Ets-1 DNA-binding; Motility/polarity/chemotaxis; Oncoprotein; Transcription factor P14921 2113 11q24.3 human S282-p 449317 NSLQRVPsYDSFDSE Ets1_N_flank protein stabilization; molecular association, regulation; activity, inhibited transcription, inhibited COP1(INDUCES) DNA(DISRUPTS) 12475968; 25024220; 25117710 7 10 87 induces autoinhibition -Grin2b NMDAR2B Channel, calcium; Channel, ligand-gated; Membrane protein, integral; Membrane protein, multi-pass Q00960 24410 4q43 rat S1303-p 450171 NKLRRQHsYDTFVDL NMDAR2_C molecular association, regulation; intracellular localization; phosphorylation signaling pathway regulation CAMK2A(DISRUPTS) 10764765; 29422059; 32415270 48 14 31 pathway regulating Rd-induced protection from extrasynaptic NMDAR-triggered neuronal injury; reduced membrane expression CaMKII, reduced phosphorylation of GluR1 -MUC1 MUC1 Actin-binding; Cell adhesion; Membrane protein, integral; Motility/polarity/chemotaxis; Nuclear receptor co-regulator; Tumor suppressor P15941 4582 1q22 human Y1218-p 473759 TYHTHGRyVPPSSTD intracellular localization cell motility, altered 17545600 1 5 56 nuclear localization; Phosphorylation enhanced invasion in vitro, through Matrigel. -ULK1 ULK1 Autophagy; EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, Other; Protein kinase, Ser/Thr (non-receptor) O75385 8408 12q24.33 human K68-ac 1881147401 GKEIKILkELKHENI autophagy, inhibited 33431796 1 1 0 may reduce pyroptosis -KMT5A SETD8 Amino Acid Metabolism - lysine degradation; EC 2.1.1.43; METHYLTRANSFERASE; Methyltransferase; Methyltransferase, protein lysine Q9NQR1 387893 12q24.31 human S100-p 3213381 SKIYSYMsPNKCSGM protein stabilization; ubiquitination; intracellular localization cell cycle regulation 20966048 1 6 0 phosphorylation of this site results in the removal of SETD8 from mitotic chromosomes; inhibits SETD8 ubiquitination -Stat1 STAT1 DNA-binding; Transcription factor Q9QXK0 25124 9q22 rat K703-sm 3278913 PKRTGYIkTELISVS molecular association, regulation DNA(DISRUPTS) 21102409 9 3 0 increased sumoylation (decreased phosphorylation) improved spatial learning -MAPT Tau iso3 ACETYLTRANSFERASE; Acetyltransferase; Cytoskeletal P10636-3 4137 17q21.31 human S199-p 449328 KVTSKCGsLGNIHHK Tubulin-binding autophagy, inhibited 33967735 12 8 2 -NOS2 iNOS Amino Acid Metabolism - arginine and proline; EC 1.14.13.39; Oxidoreductase P35228 4843 17q11.2 human Y151-p 457593 IEFVNQYyGSFKEAK NO_synthase intracellular localization; enzymatic activity, inhibited 16116474 3 0 0 -BEST1 BEST1 Channel, chloride; Membrane protein, integral; Membrane protein, multi-pass; Transporter; Transporter, ion channel O76090 7439 11q12.3 human Y227-p 28706303 QCGHLYAyDWISIPL Bestrophin intracellular localization 23880862 1 0 0 Basolateral localization and delivery -Exoc8 EXOC8 Vesicle O54924 245709 19q12 rat S366-p 182950104 EDKPSPPsVKELRAK Exo84_C molecular association, regulation exocytosis, inhibited Sec5(DISRUPTS); EXOC8(DISRUPTS) 28325821 1 1 0 -FOXO1 FOXO1A DNA-binding; Nuclear receptor co-regulator; Oncoprotein; Transcription factor Q12778 2308 13q14.11 human S256-p 448075 SPRRRAAsMDNNSKF protein degradation; molecular association, regulation; intracellular localization; activity, inhibited; phosphorylation carcinogenesis, inhibited; cell growth, induced; transcription, altered; transcription, inhibited 14-3-3 beta(INDUCES); SKP2(INDUCES); PCAF(INDUCES) DNA(DISRUPTS) 10358076; 11237865; 12228231; 14664696; 15668399; 15934941; 16076959; 16670091; 20041807; 20061393; 20357092; 20519497; 21980390; 22081023; 23995784; 35679032; 36756789 98 8 48 -TRPM6 ChaK2 Channel, cation; EC 2.7.11.1; KINASE; Kinase, protein; Membrane protein, integral; Membrane protein, multi-pass; Protein kinase, Ser/Thr (non-receptor); Protein kinase, atypical Q9BX84 140803 9q21.13 human T1851-p 2255402 FNQVKPQtIPYTPRF Alpha_kinase activity, inhibited 18258429 2 2 0 RACK1-induced inhibition of channel activity is dependent on T1851 phosphorylation -NPFFR2 NPFFR2 GPCR, family 1; Membrane protein, integral; Membrane protein, multi-pass; Receptor, GPCR Q9Y5X5 10886 4q13.3 human T517-p 36533412 MEELKETtNSSEI__ receptor desensitization, induced 25326382 1 1 0 -PRKG1 PKG1 EC 2.7.11.12; KINASE; Kinase, protein; Protein kinase, AGC; Protein kinase, Ser/Thr (non-receptor) Q13976 5592 10q11.23-q21.1 human T517-p 452153 GFGKKTWtFCGTPEY Pkinase phosphorylation; enzymatic activity, induced transcription, altered 10644746 3 4 13 promotes phosphorylation of p38 and ATF2-dependent transcription -DYRK2 DYRK2 iso2 EC 2.7.12.1; KINASE; Kinase, protein; Protein kinase, CMGC; Protein kinase, dual-specificity (non-receptor) Q92630-2 8445 12q15 human S501-p 1874397824 PPPSSSAsKLRTNLA enzymatic activity, induced cell cycle regulation; apoptosis, induced 34363019 1 1 0 -TERF1 TRF1 DNA-binding P54274 7013 8q21.11 human T273-p 6417401 SKRTRTItSQDKPSG protein stabilization; molecular association, regulation; phosphorylation carcinogenesis, induced; chromatin organization, altered; cell growth, induced; transcription, inhibited DNA(INDUCES) 33690611 2 0 0 binds telomeric DNA, inhibits CHK phosphorylation -PARP1 PARP1 DNA repair, damage; EC 2.4.2.30; Nuclear envelope; Nuclear receptor co-regulator; Nucleolus; Transferase P09874 142 1q42.12 human K249-ub 12396812 NDLIWNIkDELKKVC protein degradation; ubiquitination 34555594 1 4 1 vascular injury and remodeling by increasing PARP1-K249 acetylation and PARP1 levels in mice -MBD1 MBD1 Transcription factor Q9UIS9 4152 18q21.1 human K538-sm 3144813 DPGLPSVkQEPPDPE molecular association, regulation transcription, induced SETDB1(DISRUPTS) 17066076 1 3 0 -ROCK2 ROCK2 EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, AGC; Protein kinase, Ser/Thr (non-receptor) O75116 9475 2p25.1 human Y722-p 464192 LADKNKIyESIEEAK molecular association, regulation; enzymatic activity, inhibited cell motility, altered; cell adhesion, altered; signaling pathway regulation RHOA(DISRUPTS) 18559669; 31722979 5 7 127 -HAUS8 HAUS8 Cell cycle regulation Q9BT25 93323 19p13.11 human S133-p 20609208 KPESTSFsAPRKKSP intracellular localization cell cycle regulation; apoptosis, inhibited 21690413 1 2 0 localization to the spindle -TUBA1B TUBA1B Cytoskeletal; Motility/polarity/chemotaxis P68363 10376 12q13.12 human K394-me 476774 AWARLDHkFDLMYAK molecular association, regulation Other(DISRUPTS) 8097117 1 0 0 inhibits microtubule assembly -Map3k2 MEKK2 EC 2.7.11.25; KINASE; Kinase, protein; Protein kinase, STE; Protein kinase, Ser/Thr (non-receptor) F1M9D0 171492 18p12 rat S164-p 1984188 PPNRDRSsPPPGYIP apoptosis, induced 28039298 1 24 10 -ITGB1 ITGB1 Cell adhesion; Cell surface; Membrane protein, integral; Motility/polarity/chemotaxis; Receptor, misc. P05556 3688 10p11.22 human T789-p 447709 IYKSAVTtVVNPKYE Integrin_b_cyt activity, induced; molecular association, regulation; protein conformation cell adhesion, induced; cell motility, altered; cell adhesion, altered FLNA(DISRUPTS); kindlin-2(DISRUPTS); talin 1(DISRUPTS) 14660602; 15949469; 19115199; 33119040 14 3 1 -RUNX3 AML2 DNA-binding; Transcription factor Q13761 864 1p36.11 human K129-m2 1877292604 RNASAVMkNQVARFN Runt molecular association, regulation cell cycle regulation; carcinogenesis, induced; cell growth, induced; transcription, inhibited CBFB(DISRUPTS); p300(DISRUPTS) 33116296 1 1 0 -MST1R Ron EC 2.7.10.1; KINASE; Kinase, protein; Membrane protein, integral; Protein kinase, TK; Protein kinase, tyrosine (receptor) Q04912 4486 3p21.31 human Y1238-p 454933 RDILDREyYSVQQHR PK_Tyr_Ser-Thr protein conformation; phosphorylation; enzymatic activity, induced cell cycle regulation; carcinogenesis, inhibited; cell growth, inhibited 20726546; 24739671; 35569509 8 7 183 -Eif2ak4 GCN2 EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, Other; Protein kinase, Ser/Thr (non-receptor); Translation Q9QZ05 27103 2|2 E5 mouse T898-p 455461 SDPSGHLtGMVGTAL Pkinase transcription, induced 36273589 5 0 0 -RANBP2 RANBP2 Adaptor/scaffold; EC 5.2.1.8; EC 6.3.2.-; Ligase; Nuclear export; Nucleoporin; SUMO LIGASE; SUMO conjugating system; SUMO ligase P49792 5903 2q13 human S2246-p 468567 SSSSVHAsPLASSPV molecular association, regulation; intracellular localization BICD2(INDUCES) 26051540 1 29 0 targets BicD2 to the NE of RGP cells to induce apical nuclear migration -ETS1 Ets-1 DNA-binding; Motility/polarity/chemotaxis; Oncoprotein; Transcription factor P13474 396235 chicken S257-p 449319 DSFESIEsYDSCDRL Ets1_N_flank activity, inhibited 7961750 4 0 1 The in vitro interaction of Ets-1 with a high-affinity Ets binding site was assayed with EMSA. -YAP1 YAP1 iso2 Oncoprotein; Transcription, coactivator/corepressor P46937-2 10413 11q22.1 human S109-p 452305 KSHSRQAsTDAGTAG activity, inhibited cell differentiation, induced; cell growth, inhibited; transcription, inhibited 23027127; 23752589 23 63 341 -Tfeb TFEB DNA-binding; Transcription factor Q9R210 21425 17 C|17 23.99 cM mouse S210-p 25529700 MVGVTSSsCPADLTQ intracellular localization transcription, inhibited 36097072 22 3 0 -XRCC5 Ku80 DNA-binding; EC 3.6.1.-; EC 3.6.4.-; Helicase; Nuclear receptor co-regulator; Nucleolus; RNA-binding P13010 7520 2q35 human K285-ub 62489909 VVDAKTLkKEDIQKE Ku molecular association, regulation DNA repair, induced DNA(DISRUPTS) 27895153 1 0 0 -Slc29a1 SLC29A1 Membrane protein, integral; Membrane protein, multi-pass; Transporter; Transporter, SLC family Q9JIM1 63959 17|17 B3 mouse S254-p 486282 ETKLDLIsKGEEPKG Nucleoside_tran activity, induced; molecular association, regulation cell growth, induced SLC29A1(DISRUPTS) 17520485 2 10 0 -Gja1 GJA1 Channel, misc.; Membrane protein, integral; Membrane protein, multi-pass; Motility/polarity/chemotaxis P08050 24392 20q11 rat S279-p 448853 SSPTAPLsPMSPPGY molecular association, regulation; intracellular localization; activity, inhibited; phosphorylation endocytosis, induced GJA1(INDUCES) 23363606; 23922949; 26841867; 30981509; 9535909 42 6 1 Phosphorylation of S279 impairs Cx43 assembly into gap junctions. -PPP1CC PPP1CC EC 3.1.3.16; Motility/polarity/chemotaxis; Nucleolus; PHOSPHATASE; Protein phosphatase, Ser/Thr (non-receptor) P36873 5501 12q24.11 human T311-p 3913895 PNATRPVtPPRGMIT enzymatic activity, inhibited 20948546 1 9 30 -GNA15 G-alpha 15 G protein; G protein, heterotrimeric; G protein, heterotrimeric alpha G(q) P30679 2769 19p13.3 human S336-p 11380905 GSKKGARsRRLFSHY G-alpha activity, induced 12647293 1 0 0 GNA15 receptor mediated PLC-B activation -EIF4EBP1 4E-BP1 Translation; Translation initiation Q13541 1978 8p11.23 human S112-p 447526 KRAGGEEsQFEMDI_ eIF_4EBP molecular association, regulation; phosphorylation EIF4E(DISRUPTS) 12588975 5 15 28 Deletion of (QFEMDI) sequence affected phosphorlation of multiple phosphorylation sites. ; S111 did not affect binding to EIF4E. -NUP98 NUP98 iso2 Motility/polarity/chemotaxis; Nucleoporin P52948-2 4928 11p15.4 human S606-p 452729 RDSENLAsPSEYPEN intracellular localization 21335236 1 71 6 as multiple sites (13PM) mutant -CD44 CD44 iso12 Cell adhesion; Membrane protein, integral; Motility/polarity/chemotaxis; Receptor, misc. P16070-12 960 11p13 human S291-p 455524 AVCIAVNsRRRCGQK molecular association, regulation; protein conformation Moesin(DISRUPTS) 25925953; 26217011 5 0 0 regulates dimer formation and ectodomain cleavage; inhibits clevage, TPA induced CD44 cleavage requires dephosphorylation of S291 -FBP1 FBPase Carbohydrate Metabolism - fructose and mannose; Carbohydrate Metabolism - glycolysis and gluconeogenesis; Carbohydrate Metabolism - pentose phosphate pathway; EC 3.1.3.11; Mitochondrial; Phosphatase (non-protein) P09467 2203 9q22.32 human S144-p 15501075 FGIYRKKsTDEPSEK FBPase molecular association, regulation carcinogenesis, induced; cell motility, induced; cell growth, induced; transcription, induced; signaling pathway regulation CHIP(DISRUPTS); NFkB-p65(DISRUPTS) 32754266 1 4 3 induces NFKB binding to DNA, regulates NFKB pathway -TJP2 ZO2 Adaptor/scaffold; Motility/polarity/chemotaxis Q9UDY2 9414 9q21.11 human K730-sm 1883981501 LLREAGFkRPVVLFG protein stabilization; molecular association, regulation occludin(INDUCES); ZO1(INDUCES) 36291162 1 0 0 stability of hZO-2 is regulated by K48 polyubiquitin and K759, K997 ubiquitylation and K730 SUMOylation, mutations in ZO2 ubiquitylation and ylation sites disrupt the interaction with occludin and ZO1as well as tight junction (TJ) barrier function -Cttn Cortactin Actin-binding; Cytoskeletal; Motility/polarity/chemotaxis Q60598 13043 7|7 F5 mouse Y482-p 447704 YQAEDDTyDGYESDL molecular association, regulation cell motility, induced; cytoskeletal reorganization CBLL1(INDUCES); MTUS2(DISRUPTS); VAV2(INDUCES); FAK(DISRUPTS); smMLCK(INDUCES) 12408982; 17343955; 22078467; 22252131; 22952866; 27451391; 34439396 25 1 3 Tyr to Phe mutation of this site prevents FAK-mediated FA turnover -Pld2 PLD2 EC 3.1.4.4; Lipid Metabolism - ether lipid; Lipid Metabolism - glycerophospholipid; Motility/polarity/chemotaxis; Phospholipase P97813 18806 11 B3|11 42.99 cM mouse Y470-p 453412 GRWDDVQyRLTDLGD intracellular localization 15282299 1 0 0 Y14 F and YallF showed altered location in cytoplasm rather than at the plasmamembrane. -Cysltr1 CYSLTR1 GPCR, family 1; Membrane protein, integral; Membrane protein, multi-pass; Receptor, GPCR Q99JA4 58861 X|X D mouse T323-p 11143513 NFRRRLStFRKHSLS receptor desensitization, induced 23485744 1 0 2 -ARHGAP17 ARHGAP17 GAP; GAP, Rac/Rho Q68EM7 55114 16p12.1 human S702-p 472376 LSAPRRYsSSLSPIQ molecular association, regulation; intracellular localization TRIP10(DISRUPTS); FNBP1L(INDUCES) 26507661; 36571786 2 13 34 regulates invadopodia disassembly -Ccnt1 CCNT1 Cell cycle regulation; Transcription initiation complex Q9QWV9 12455 15|15 F1 mouse K386-ac 25174700 SKSVPSAkVSLKEYR molecular association, regulation; enzymatic activity, induced transcription, induced BCDIN3(DISRUPTS); HEXIM1(DISRUPTS) 19387490 3 1 0 enhances CDK9/cyclin T1 transcriptional activity, disrupting HEXIM1 and BCDIN3 association -G6PD G6PD Carbohydrate Metabolism - pentose phosphate pathway; Cell development/differentiation; EC 1.1.1.49; Other Amino Acids Metabolism - glutathione; Oxidoreductase P11413 2539 Xq28 human T145-p 1883583400 FYLALPPtVYEAVTK molecular association, regulation; enzymatic activity, induced cell growth, induced Other(INDUCES) 37478541 1 0 0 induces binding to NADP -DPYSL2 CRMP-2 Microtubule-binding; Motility/polarity/chemotaxis Q16555 1808 8p21.2 human T514-p 454386 SVTPKTVtPASSAKT molecular association, regulation; intracellular localization carcinogenesis, inhibited; apoptosis, induced; cell motility, inhibited; cytoskeletal reorganization DRP1(DISRUPTS); RHOT2(DISRUPTS); RECK(DISRUPTS); Tau iso8(INDUCES); MFN2(DISRUPTS) 28500272; 32019603; 32778769; 34831395; 34975828; 37174687 33 36 35 -Gja1 GJA1 Channel, misc.; Membrane protein, integral; Membrane protein, multi-pass; Motility/polarity/chemotaxis P08050 24392 20q11 rat S330-p 449994 AGSTISNsHAQPFDF Connexin43 intracellular localization cell adhesion, induced; cell adhesion, altered; signaling pathway regulation 12270943; 23742896 10 14 0 cardiomyocyte FGF signaling, maintenance of cell-cell gap junctions -Insr INSR EC 2.7.10.1; KINASE; Kinase, protein; Membrane protein, integral; Protein kinase, TK; Protein kinase, tyrosine (receptor) P15208 16337 8 A1.1|8 1.82 cM mouse Y1175-p 447680 FGMTRDIyETDYYRK PK_Tyr_Ser-Thr cell cycle regulation; cell motility, altered 18515860 38 31 455 -Htt Huntingtin Cytoskeletal P42859 15194 5 B2|5 17.92 cM mouse S16-p 12056100 KAFESLKsFQQQQQQ protein degradation; molecular association, regulation; intracellular localization TPR(DISRUPTS) 21245084 18 2 0 -TP53 p53 Activator; DNA-binding; Motility/polarity/chemotaxis; Nuclear receptor co-regulator; Transcription factor; Tumor suppressor P04637 7157 17p13.1 human K370-ub 464661 RAHSSHLkSKKGQST protein degradation; molecular association, regulation; intracellular localization transcription, inhibited ING1(DISRUPTS) 11046142; 17371868; 19927155; 21731648 9 1 0 K370/372/373/381/382/386/R mutant shows 613-fold activation of p53; binds unmodified or six multimonoubiquitinated forms of wild-type p53 -Krt18 K18 Cytoskeletal; Nucleolus P05784 16668 15 F2|15 57.22 cM mouse S35-p 447733 RPASSAAsVYAGAGG intracellular localization cytoskeletal reorganization 10623656 14 27 13 -INTS11 INTS11 EC 3.1.27.-; RNA processing; Ribonuclease Q5TA45 54973 1p36.33 human K381-sm 1883375205 GRQVLEVkMQVEYMS RMMBL molecular association, regulation; intracellular localization 36454007 1 0 0 regulates Integrator subcellular localization and interaction with integrator subunits -Myo5a MYO5A Motility/polarity/chemotaxis; Motor Q99104 17918 9 D|9 42.26 cM mouse S1650-p 480053 GLRKRTSsIADEGTY molecular association, regulation ACTN1(INDUCES) 17515613 2 21 10 -HNRNPUL1 E1B-AP5 RNA splicing; RNA-binding Q9BUJ2 11100 19q13.2 human R656-m1 12198334 SGGGGNYrGGFNRSG molecular association, regulation; intracellular localization NBS1(INDUCES) 26020839 1 4 25 ecruitment at sites of damage -ACE2 ACE2 EC 3.4.17.23; Membrane protein, integral; Protease Q9BYF1 59272 Xp22.2 human S783-p 23078777 SGENPYAsIDISKGE protein stabilization; molecular association, regulation AP2M1(INDUCES); GABARAP(INDUCES); LC3A(INDUCES) 33436498; 35894122 2 1 2 SARS-CoV-2 infection induces GLK overexpression and subsequent ACE2 stabilization -ENG ENG Membrane protein, integral; Motility/polarity/chemotaxis; Receptor, misc. P17813 2022 9q34.11 human S646-p 12064201 STNHSIGsTQSTPCS cell motility, altered 20042635 1 0 0 regulates TGF-beta signaling via ALK1/Smad1/5/8 pathway -Rasgrp2 RASGRP2 GEF; GEF, Ras Q9QUG9 19395 19|19 A mouse S586-p 10993875 PRPGRRSsRPPEIRE activity, induced; molecular association, regulation 14-3-3 beta(INDUCES) 26804993 3 9 36 -NR4A1 Nur77 Apoptosis; DNA-binding; Nuclear receptor P22736 3164 12q13.13 human S52-p 41583604 AAPTALPsFSTFMDG cell motility, induced; cell growth, induced; cytoskeletal reorganization 26155943 1 0 0 required for increase in cell growth, cell motility, monolayer permeability, and formation of actin stress fibers. -CD28 CD28 Cell surface; Membrane protein, integral P10747 940 2q33.2 human Y218-p 450285 PPRDFAAyRS_____ activity, induced; phosphorylation carcinogenesis, inhibited; cell growth, inhibited; transcription, induced; signaling pathway regulation; transcription, altered NFkB-p65(INDUCES) 12842899; 20368329; 30131370 4 4 180 -CORO1A coronin 1A Cytoskeletal; Motility/polarity/chemotaxis P31146 11151 16p11.2 human T412-p 3995219 RVNRGLDtGRRRAAP Trimer_CC molecular association, regulation; intracellular localization endocytosis, induced ACTB(DISRUPTS) 23100250; 34189278 2 2 4 -FOXP3 FOXP3 C2H2-type zinc finger protein; Cell cycle regulation; DNA-binding; Transcription factor Q9BZS1 50943 Xp11.23 human S418-p 27623902 LEFRKKRsQRPSRCS Forkhead phosphorylation cell growth, inhibited; transcription, induced DNA(INDUCES) 23396208; 25096571; 30011797 4 0 0 UBC9 transcription induced -PDGFRB PDGFRB EC 2.7.10.1; KINASE; Kinase, protein; Membrane protein, integral; Oncoprotein; Protein kinase, TK; Protein kinase, tyrosine (receptor) P09619 5159 5q32 human S254-p 1876167502 WTYPRKEsGRLVEPV Ig_3 enzymatic activity, inhibited; phosphorylation carcinogenesis, inhibited; cell growth, inhibited; cell motility, inhibited; signaling pathway regulation 35066967 1 0 0 inhibits phosphorylation of itself on other sites, further inhibiting PI3K/Akt and MAPK/ERK pathways -NFE2L2 NRF2 DNA-binding; Transcription factor Q16236 4780 2q31.2 human K599-ac 23940021 FLVPKSKkPDVKKN_ molecular association, regulation; intracellular localization transcription, induced DNA(INDUCES) 21196497 1 0 0 -TIRAP TIRAP Adaptor/scaffold P58753 114609 11q24.2 human Y86-p 463808 SSRWSKDyDVCVCHS activity, induced; molecular association, regulation; phosphorylation transcription, induced; signaling pathway regulation TLR4(DISRUPTS); MYD88(DISRUPTS); Btk(INDUCES); P38A(INDUCES) 16439361; 18070880; 24840642; 35379857 4 0 0 TLR2/TLR4 signaling -NCL NCL DNA-binding; Helicase; Nuclear receptor co-regulator; Nucleolus; RNA-binding P19338 4691 2q37.1 human S153-p 449270 DEEEDDDsEEDEEDD intracellular localization cell cycle regulation; cell growth, induced 25313645 1 38 59 -CBL CBL Adaptor/scaffold; EC 6.3.2.-; EC 6.3.2.19; Ligase; Motility/polarity/chemotaxis; Oncoprotein; UBIQUITIN LIGASE; Ubiquitin conjugating system; Ubiquitin ligase P22681 867 11q23.3 human Y774-p 448531 SENEDDGyDVPKPPV protein degradation; molecular association, regulation; enzymatic activity, induced; phosphorylation cell growth, induced; cell motility, induced; cell adhesion, induced; cell motility, altered; signaling pathway regulation; cell growth, altered Src(INDUCES); VEGFR2(INDUCES); CRKL(INDUCES); CBL(INDUCES); CRK(INDUCES); PIK3CA(INDUCES) 11997497; 12604776; 15922744; 17372230; 21967979; 26848865; 33512474; 9988765 16 4 257 The double mutant Y700/774F was used in this study; CD93 binds to Cbl inducing phosphorylation on tyrosine 774 of CBL; induces cytokine signaling; integrin-mediated platelet outside-in signaling leading to platelet spreading; Src induces Cbl phosphorylation inducing Cbl degredation and alters EGFR desensitization. -ETV1 ETV1 DNA-binding; Oncoprotein; Transcription factor P50549 2115 7p21.2 human K33-ac 458950 PTNVRKRkFINRDLA ETS_PEA3_N protein stabilization; molecular association, regulation transcription, induced DNA(INDUCES) 12917345 1 0 0 -Nr3c1 GR DNA-binding; Mitochondrial; Nuclear receptor; Transcription factor P06537 14815 18 B3|18 21.09 cM mouse S229-p 447968 PGKETNEsPWRSDLL GCR transcription, induced; transcription, inhibited; signaling pathway regulation 21994940; 30738183 51 5 0 -TNFRSF10A TRAIL-R1 Membrane protein, integral O00220 8797 8p21.3 human S424-gl 1873593500 NKTGRNAsIHTLLDA Death apoptosis, induced 30987996 1 0 0 TRAIL-mediated cell death apoptosis and necrosis, TRAIL resistance -CSNK1E CK1E EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, CK1; Protein kinase, Ser/Thr (non-receptor) P49674 1454 22q13.1 human S405-p 449794 EVSRIPAsQTSVPFD enzymatic activity, inhibited 10542239; 12223474 2 18 4 some subset of these 8 sites -PSIP1 LEDGF Motility/polarity/chemotaxis; Transcription, coactivator/corepressor O75475 11168 9p22.3 human K364-sm 13875714 AEIKNSLkIDNLDVN LEDGF protein degradation; molecular association, regulation cell growth, inhibited; transcription, inhibited DNA(DISRUPTS) 20382164; 22748127 2 0 0 -SCAP SCAP Membrane protein, integral; Membrane protein, multi-pass Q12770 22937 3p21.31 human K305-ub 1877340000 YIYFSTRkIDMVKSK activity, induced; protein conformation transcription, induced 32054686 1 0 0 promotes loop 1?loop 7 interaction, cholesterol biosynthesis -RUNX3 AML2 DNA-binding; Transcription factor Q13761 864 1p36.11 human T209-p 25526800 ERLRMRVtPSTPSPR protein degradation; molecular association, regulation; ubiquitination; intracellular localization; activity, inhibited carcinogenesis, induced; cell growth, induced; transcription, altered HSP90A(INDUCES); HSC70(INDUCES); ANXA2(INDUCES); PIN1(INDUCES); hnRNP A1(INDUCES) 22580604; 26898755; 34253860 3 3 0 -PRC1 PRC1 Cell cycle regulation; Cytoskeletal; Microtubule-binding; Motility/polarity/chemotaxis O43663 9055 15q26.1 human T481-p 483541 RRGLAPNtPGKARKL activity, induced; intracellular localization; activity, inhibited; phosphorylation cell cycle regulation; carcinogenesis, inhibited; cell growth, induced; chromatin organization, altered; cytoskeletal reorganization 16603632; 17512944; 24120663; 27551054; 30626720; 30992425; 34158398 11 21 12 -TP53 p53 Activator; DNA-binding; Motility/polarity/chemotaxis; Nuclear receptor co-regulator; Transcription factor; Tumor suppressor P04637 7157 17p13.1 human R335-m2 5009202 FTLQIRGrERFEMFR P53_tetramer cell cycle regulation; apoptosis, inhibited; transcription, altered 53BP1(INDUCES) 19011621 1 1 0 PRMT5 enhanced p53-dependent cell-cycle arrest; after treatment with PRMT5 theere was a reduction in dimer and tetramer formation; arginine methylation affects the promoter specificity of p53 -Sik1 SIK EC 2.7.11.1; KINASE; Kinase, protein; Motility/polarity/chemotaxis; Protein kinase, CAMK; Protein kinase, Ser/Thr (non-receptor); Tumor suppressor Q60670 17691 17 B1|17 17.25 cM mouse T475-p 15570318 GSTGRRHtLAEVSTH protein stabilization; intracellular localization 23256157 1 4 1 -FCRL4 FCRL4 Membrane protein, integral Q96PJ5 83417 1q23.1 human Y493-p 22730003 DKDVSVVySEVKTQH molecular association, regulation signaling pathway regulation Ig-alpha(INDUCES) 21908428; 25972488 2 0 0 all 3 sites (Y451, Y463, Y493) inhibits BCR signaling and enhances TLR9 signaling -Tbc1d1 TBC1D1 DEUBIQUITINASE; GAP; GAP, Rab; Ubiquitin-specific protease Q60949 57915 5 C3.1|5 32.8 cM mouse T590-p 1247778 AFRRRANtLSHFPVE activity, inhibited; phosphorylation 18215134; 19740738 11 13 137 reduces inhibitory effect on TBC1D1 on GLUT4 translocation; p70S6K phosphorylation -Ephb2 EphB2 EC 2.7.10.1; KINASE; Kinase, protein; Membrane protein, integral; Protein kinase, TK; Protein kinase, tyrosine (receptor); Tumor suppressor P54763 13844 4 D3|4 69.0 cM mouse Y504-p 139835700 GLKAGAIyVFQVRAR fn3 molecular association, regulation; intracellular localization NMDAR1(INDUCES) 28719605 1 1 0 cell surface,retain NMDARs to spine synapse, pathological pain, mechanical hypersensitivity -LMNA lamin A/C Cytoskeletal P02545 4000 1q22 human T10-p 1244434 TPSQRRAtRSGAQAS molecular association, regulation lamin A/C(DISRUPTS) 35839855 1 4 44 -Scn2a SCN2A Channel, sodium; Membrane protein, integral; Membrane protein, multi-pass P04775 24766 3q21 rat S576-p 2999206 PRRNSRAsLFNFKGR Na_trans_cytopl activity, induced 12359152 1 3 1 -Ric8a RIC8A GEF; GEF, misc. Q3TIR3 101489 7|7 F4 mouse S501-p 3213318 VIQPMGMsPRGHLTS Ric8 intracellular localization cytoskeletal reorganization 24092753 2 37 2 dorsal ruffle turnover, phosphorylated S501 localization in the cytoplasm -FOXO1 FOXO1A DNA-binding; Nuclear receptor co-regulator; Oncoprotein; Transcription factor Q12778 2308 13q14.11 human K248-ac 459031 PEGGKSGkSPRRRAA Forkhead molecular association, regulation; intracellular localization; activity, inhibited; phosphorylation carcinogenesis, inhibited; apoptosis, induced; transcription, inhibited DNA(DISRUPTS) 15220471; 16076959; 18786403; 20519497; 27132507 9 1 0 -EFHD2 EFHD2 Calcium-binding Q96C19 79180 1p36.21 human S183-p 28761200 RLSEIDVsSEGVKGA protein conformation cytoskeletal reorganization 23959172; 28011271 2 1 0 cofilin-induced actin depolymerization, modulates cofilin distribution to the leading edges of lamellipodia induced by EGF, regulation of lamellipodia dynamics; re-orientation of actin-binding sites, reduction in actin-bundling activity -Prkcd PKCD EC 2.7.11.13; KINASE; Kinase, protein; Nuclear receptor co-regulator; Protein kinase, AGC; Protein kinase, Ser/Thr (non-receptor); Protein kinase, tyrosine (non-receptor); Tumor suppressor P09215 170538 16p16 rat Y523-p 450231 EILQGLKySFSVDWW Pkinase enzymatic activity, induced 9326592 4 0 0 -Stim1 STIM1 Calcium-binding; Endoplasmic reticulum; Membrane protein, integral P70302 20866 7 E2-E3|7 54.71 cM mouse S621-p 3635048 SHSLSPSsPDPDTPS molecular association, regulation; protein conformation ORAI1(INDUCES); EB1(INDUCES) 20736304; 23687376 8 11 1 calcium mobilization and EB1-dependent STIM1 multimerization ; regulate store operated calcium entry (SOCE) -IKBKG IKKG Adaptor/scaffold; Protein kinase, regulatory subunit Q9Y6K9 8517 Xq28 human K325-ub 7482001 AREKLAEkKELLQEQ CC2-LZ signaling pathway regulation 17728323 2 0 1 -Th TH Amino Acid Metabolism - tyrosine; EC 1.14.16.2; Endoplasmic reticulum; Mitochondrial; Oxidoreductase; Vesicle P04177 25085 1q41 rat S8-p 448543 MPTPSAPsPQPKGFR TOH_N protein stabilization 15639226 5 1 0 Phosphorylation of S8 S19 and S31 (more stable) may stabilize TH already phosphorylated at S40 (least stable). -NPHS1 NPHS1 Cell adhesion; Immunoglobulin superfamily; Membrane protein, integral O60500 4868 19q13.12 human Y1176-p 2299202 MAFPGHLyDEVERTY intracellular localization endocytosis, induced; exocytosis, induced; cell adhesion, induced; cytoskeletal reorganization 22718751; 36822326 8 0 0 -SLFN11 SLFN11 Q7Z7L1 91607 17q12 human S219-p 1869008603 LVEFKQFsTKHFQEY AlbA_2 activity, inhibited translation, induced 31395656 1 1 0 p24 expression and activity depend on S753 site -GLS glutaminase Amino Acid Metabolism - alanine, aspartate and glutamate; Amino Acid Metabolism - arginine and proline; EC 3.5.1.2; Energy Metabolism - nitrogen; Hydrolase; Mitochondrial; Other Amino Acids Metabolism - D-Glutamine and D-glutamate O94925 2744 2q32.2 human K158-ub 22244990 QEKIPVHkFITALKS EF-hand_14 protein degradation; ubiquitination; succinylation carcinogenesis, inhibited; cell growth, inhibited 31843902 1 2 0 SIRT5 downregulated -GRIN1 NMDAR1 Channel, calcium; Channel, ligand-gated; Membrane protein, integral; Membrane protein, multi-pass Q05586 2902 9q34.3 human Y837-p 17613300 LIFIEIAyKRHKDAR CaM_bdg_C0 molecular association, regulation CSK(INDUCES) 21113815 1 0 0 Y837F mutation prevents the CSK-induced down-regulation of NMDAR1 activity -PKD1 PKD1 Cell adhesion; Membrane protein, integral; Membrane protein, multi-pass P98161 5310 16p13.3 human S4252-p 466929 SLQGRRSsRAPAGSS cell differentiation, altered 17980165 2 0 0 -Cbx5 HP1 alpha Transcription, coactivator/corepressor Q61686 12419 15|15 F3 mouse S14-p 476165 RTADSSSsEDEEEYV molecular association, regulation H3(INDUCES) DNA(INDUCES) 21245376 1 42 3 important for chromosomal stability -IRF3 IRF3 DNA-binding; Transcription factor Q14653 3661 19q13.33 human S402-p 449030 ISNSHPLsLTSDQYK activity, induced; protein degradation; molecular association, regulation; intracellular localization autophagy, induced; transcription, induced; transcription, altered CALCOCO2(INDUCES) 18272581; 19153595; 25070846; 27992402; 37330913; 9566918 9 3 0 GPR108 and Smurf1 mediated degradation requires NDP52; NDP52-dependent autophagic degradation of phosphorylated IRF3; GPR108 interacts with Smurf1, followed by the recruitment of IRF3 during viral infection -PREB PREB GEF, misc.; Membrane protein, integral; Transcription factor Q9HCU5 10113 2p23.3 human Y10-p 1868624703 RRRAPELyRAPFPLY activity, inhibited signaling pathway regulation 31227593 1 0 0 regulates endoplasmic reticulum (ER) signaling -Mafb MAFB DNA-binding; Oncoprotein; Transcription factor; Tumor suppressor P54841 16658 2 H2|2 80.92 cM mouse T62-p 11555107 VSSTPLStPCSSVPS protein degradation 19932079 1 0 0 -ABL1 Abl EC 2.7.10.2; KINASE; Kinase, protein; Oncoprotein; Protein kinase, TK; Protein kinase, tyrosine (non-receptor) P00519 25 9q34.12 human Y70-p 462900 PNLFVALyDFVASGD SH3_1 activity, induced; molecular association, regulation; enzymatic activity, induced Abi-1(DISRUPTS) 16912036; 18775435 2 0 12 -GRHL1 GRHL1 Transcription factor Q9NZI5 29841 2p25.1 human S76-p 3252757 KVPRERRsSTAKPEV intracellular localization cell cycle regulation; carcinogenesis, induced; cell growth, induced; transcription, induced 33931584 1 1 4 -LRRC45 LRRC45 Q96CN5 201255 17q25.3 human S661-p 28850300 VLAYVQAsPVRTLSP molecular association, regulation; protein processing; intracellular localization cell cycle regulation CEP250(INDUCES); CROCC(INDUCES) 24035387 1 4 0 phosphorylation of LRRC45 affects the assembly of its filament structure, centrosome localization- leading to centrosome separation -Ripk1 RIPK1 EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, Ser/Thr (non-receptor); Protein kinase, TKL Q60855 19766 13 A3.3|13 14.01 cM mouse K612-ub 2188102 ERDGLKEkVYQMLQK Death ubiquitination; enzymatic activity, induced apoptosis, induced FADD(INDUCES); CASP8(INDUCES) 33311474 4 4 0 Ripk1 K612R/K612R mice develop adult-onset intestinal in?ammation and splenomegaly, antibiotics rescues spontaneous gut in?ammation of RIPK1 K612R mutant mice; RDA (RIPK1 kinase dependent apoptosis) and necroptosis in response to TNFR1 signaling, p-IKKa/?, p-ERK1/2, p-JNK, and p-P38 were decreased in TNFa stimulated Ripk1K612R/K612R MEFs ; K627 localized in DD is a key ubiquitination site that can regulate the overall ubiquitination pattern of RIPK; cells stimulated by T/S and T/5Z-7; K627 in hRIPK1 is important for RIPK1 homodimerization -TP53 p53 Activator; DNA-binding; Motility/polarity/chemotaxis; Nuclear receptor co-regulator; Transcription factor; Tumor suppressor P04637 7157 17p13.1 human Y220-p 34824801 RHSVVVPyEPPEVGS P53 protein degradation; molecular association, regulation; activity, inhibited carcinogenesis, induced; DNA repair, inhibited HERC5(INDUCES) 25071020 1 0 0 promotes ISGylation -CHD4 CHD-4 DNA-binding; EC 3.6.4.12; Helicase Q14839 1108 12p13.31 human S308-p 471447 FGSKRKRsSSEDDDL molecular association, regulation chromatin organization, altered; transcription, induced DNA(DISRUPTS); RNA(DISRUPTS) 29907651 1 11 4 -BLM BLM DNA repair, damage; DNA replication; EC 3.6.4.12; Helicase P54132 641 15q26.1 human K317-sm 2293704 SASSSSSkCLSTLKD BLM_N intracellular localization; phosphorylation chromatin organization, altered 15829507; 31171703 3 0 0 localization to PML bodies determined by the ratio of SUMO and SIM in telomere clustering scaffolds; inhibits phosphorylation of H2AX -GATA2 GATA2 Transcription factor P23769 2624 3q21.3 human S192-p 14573920 PSTTGAAsPASSSAG molecular association, regulation; intracellular localization; phosphorylation carcinogenesis, induced; transcription, induced DNA(INDUCES) 25056917; 27545880 2 6 0 chromatin occupancy, nuclear foci localization; S192-dependent GATA-2 hyperphosphorylation -PAGE4 PAGE4 Cancer Testis Antigen (CTA) O60829 9506 Xp11.23 human T85-p 15421970 GSDVKEKtPPNPKHA GAGE protein conformation 28289210 1 2 0 -MIS18A MIS18A Cell cycle regulation Q9NYP9 54069 21q22.11 human S36-p 18012204 SLLGKRLsEDSSRHQ cell cycle regulation 29416714 1 9 1 necessary for faithful mitotic division; enhances PLK1 kinetochore recruitment -KIF14 KIF14 Microtubule-binding; Motor Q15058 9928 1q32.1 human S1219-p 114810407 KNLHSSHsSGLMDKS intracellular localization 28630147 1 0 0 spindle localization of Kif14 in anaphase -Rorc RORC DNA-binding; Nuclear receptor; Transcription factor P51450 19885 3|3 F2.1 mouse S203-p 4708350 ASCHLEYsPERGKAE transcription, altered 35294872 1 3 0 -Ptpn11 SHP-2 EC 3.1.3.48; Motility/polarity/chemotaxis; PHOSPHATASE; Protein phosphatase, tyrosine (non-receptor) P35235 19247 5|5 F mouse Y542-p 448492 SKRKGHEyTNIKYSL molecular association, regulation; intracellular localization; enzymatic activity, induced transcription, induced; cell adhesion, altered; signaling pathway regulation GRB2(INDUCES); SHPS1(INDUCES); Vinculin(INDUCES); Calnexin(INDUCES); GRP78(INDUCES); IP3R1(INDUCES) 11779868; 12923167; 16905534; 33574084; 34582250; 35034964 38 25 442 -H2AX H2AX DNA repair, damage; DNA-binding; Helicase P16104 3014 11q23.3 human Y142-p 3397700 ATQASQEy_______ molecular association, regulation cell cycle regulation; carcinogenesis, inhibited; cell growth, inhibited; apoptosis, induced; cell motility, inhibited; signaling pathway regulation; DNA repair, altered; transcription, inhibited Fe65(INDUCES); JNK1(INDUCES) 19234442; 20703100; 31151422; 34711990 10 2 2 -Cd300lf IREM-1 Immunoglobulin superfamily; Membrane protein, integral; Receptor, misc. Q6SJQ7 246746 11|11 E2 mouse Y276-p 474548 DHQEEVEyVTMAPFP SIT activity, induced; molecular association, regulation; intracellular localization endocytosis, induced; cytoskeletal reorganization; signaling pathway regulation PIK3R1(INDUCES) 24477292 3 0 0 1. phagocytosis of apoptotic cells 2. Activation of Rac/Cdc42 3. PI3K-Rac/Cdc42 pathway -ESR1 ER-alpha DNA-binding; Nuclear receptor; Transcription factor P03372 2099 6q25.1-q25.2 human S559-p 6048400 PTSRGGAsVEETDQS ESR1_C activity, inhibited transcription, altered 20043841 4 1 0 inhibits ligand-independent activation of ER-alpha -Tbc1d4 AS160 GAP; GAP, Rab Q8BYJ6 210789 14|14 E2.3 mouse S324-p 455925 EFRSRCSsVTGVMQK PID molecular association, regulation; phosphorylation 14-3-3 gamma(INDUCES) 19923418; 33872597 13 18 334 -MALT1 MALT1 Adaptor/scaffold; Apoptosis; EC 3.4.22.-; Ligase; Nuclear export; Protease; UBIQUITIN LIGASE; Ubiquitin conjugating system Q9UDY8 10892 18q21.32 human K677-ub 2134701 TRLSSLQkLKEHLVF MALT1_Ig protein degradation; molecular association, regulation IKKA(INDUCES) 17948050 1 1 0 activation of NF-kB pathway and IL-2 induction -SKA3 SKA3 Cell cycle regulation Q8IX90 221150 13q12.11 human T291-p 459961 PLVPTFCtPGLKIPS molecular association, regulation; intracellular localization cell cycle regulation; chromatin organization, altered; cytoskeletal reorganization HEC1(INDUCES) 32491969 1 4 0 -Grik2 GluR6 Channel, calcium; Channel, ligand-gated; Membrane protein, integral; Membrane protein, multi-pass P39087 14806 10 B3|10 24.87 cM mouse S846-p 11496000 VGEFLYKsKKNAQLE intracellular localization endocytosis, altered 19920140 5 0 0 -RAP1GAP RAP1GAP GAP; GAP, Ras; Motility/polarity/chemotaxis P47736 5909 1p36.12 human S441-p 1210678 VIRSRSQsMDAMGLS activity, induced 19218462 1 19 72 increased Rap1 activity -Gata3 GATA3 Transcription factor P23772 14462 2 A1|2 6.69 cM mouse S308-p 456464 IKPKRRLsAARRAGT cell growth, induced DNA(INDUCES) 23851685 4 0 0 binds to Il-5, IL-13 promoters, production of IL-5 and IL-13 -Lhcgr LHR GPCR, family 1; Membrane protein, integral; Membrane protein, multi-pass; Receptor, GPCR P16235 25477 6q12 rat S661-p 451062 LYRRKEFsAYTSNCK receptor internalization, altered 9660797 1 0 0 S661 is required for agonist-induced uncoupling and internalization. -TCF7L2 TCF7L2 Apoptosis; Cell cycle regulation; Cell development/differentiation; DNA-binding; Motility/polarity/chemotaxis; Transcription factor Q9NQB0 6934 10q25.2-q25.3 human K173-ac 31077502 LQSRQALkDARSPSP CTNNB1_binding protein conformation transcription, induced 23613959 1 1 0 decreases susceptibility to HBP1 mediated repression, has a strong influence on the structure of TCF7L2-DNA complex -MAPK7 ERK5 EC 2.7.11.24; KINASE; Kinase, protein; Protein kinase, CMGC; Protein kinase, Ser/Thr (non-receptor) Q13164 5598 17p11.2 human S567-p 20572700 VLSDNDRsLLERWTR intracellular localization; enzymatic activity, inhibited transcription, altered 20667468 1 2 0 -Dlg4 PSD-95 Adaptor/scaffold P31016 29495 10q24 rat T19-p 3609101 YRYQDEDtPPLEHSP receptor internalization, induced; protein degradation; intracellular localization neural plasticity; autophagy, induced 23864697; 33990590 8 0 0 regulates AMPAR mobility -PIP5K1C PIP5K1C Carbohydrate Metabolism - inositol phosphate; EC 2.7.1.68; Kinase, lipid; Motility/polarity/chemotaxis O60331 23396 19p13.3 human T553-p 487222 QPRYRRRtQSSGQDG protein degradation; intracellular localization cell motility, induced; cell adhesion, induced 27780861 1 4 35 localizing to focal adhesions, indispensable for breast cancer cell invasion -TP53 p53 Activator; DNA-binding; Motility/polarity/chemotaxis; Nuclear receptor co-regulator; Transcription factor; Tumor suppressor P04637 7157 17p13.1 human S269-p 17677100 GNLLGRNsFEVRVCA P53 protein stabilization; ubiquitination; intracellular localization; protein conformation; activity, inhibited apoptosis, altered; transcription, inhibited; transcription, altered; cell growth, altered HSP70(INDUCES) DNA(DISRUPTS) 20847049; 20851891; 20959462 3 1 0 -SNPH syntaphilin iso2 Membrane protein, integral; Vesicle O15079-2 9751 20p13 human S64-p 481340 AGSRRRTsPPVSVRD Syntaphilin cell growth, induced 34087103 1 3 1 -MFN2 MFN2 Cell cycle regulation; Cytoskeletal; EC 3.6.5.-; Hydrolase; Membrane protein, integral; Membrane protein, multi-pass; Mitochondrial O95140 9927 1p36.22 human K192-ub 31067000 NSKCPLLkDDLVLMD Dynamin_N molecular association, regulation; intracellular localization MFN2(INDUCES) 23727017 1 0 0 induces calcium mobilization, induces mitochondria-ER membrane formation (MAM) and MFN2-oligomerization -BAIAP2L1 IRTKS Adaptor/scaffold; Cytoskeletal Q9UHR4 55971 7q21.3-q22.1 human Y163-p 462516 YEHKEIEyVETVTSR IMD cell motility, induced 21840312 1 7 95 -CYTH2 cytohesin 2 GEF; GEF, ARF Q99418 9266 19q13.33 human T276-p 30306600 LGGGRVKtWKRRWFI PH molecular association, regulation; protein conformation signaling pathway regulation 24303080 1 0 0 association with membranes, activation of Arf6 -APC APC Motility/polarity/chemotaxis; Tumor suppressor P25054 324 5q22.2 human S1501-p 999605 ESTPDGFsCSSSLSA APC_r phosphorylation 17910481 1 0 0 phosphorylation by GSK3 primes for S1504 and S1507 phosphorylation by CK1 -GRIN2A NMDAR2A Channel, ligand-gated; Membrane protein, integral; Membrane protein, multi-pass Q12879 2903 16p13.2 human S900-p 2897403 NMLKLLRsAKNISSM NMDAR2_C receptor desensitization, inhibited 23503100 2 0 0 increase in synaptic NR current by phosphorylation of Ser-900, 929 -Slc12a5 KCC2 Membrane protein, integral; Membrane protein, multi-pass; Transporter; Transporter, SLC family Q91V14 57138 2|2 H3 mouse T1029-p 10045602 TDPEVHLtWTKDKSV protein degradation; molecular association, regulation; ubiquitination; activity, inhibited cell growth, altered FBXL4(INDUCES) 31615901; 36973513 9 5 1 necessary for neuronal proliferation and /or migration in developing forebrain -Trpv1 TRPV1 Channel, cation; Membrane protein, integral; Membrane protein, multi-pass; Receptor, misc. Q704Y3 193034 11 B4|11 45.25 cM mouse S801-p 450017 VPLLRDAsTRDRHST receptor desensitization, altered 31676602 21 0 0 Regulates spontaneous pain during masseter inflammation; regulates inflammation mediated sensitization -FOXO1 FOXO1A DNA-binding; Nuclear receptor co-regulator; Oncoprotein; Transcription factor Q12778 2308 13q14.11 human R253-me 5009204 SGKSPRRrAASMDNN protein stabilization; intracellular localization; phosphorylation apoptosis, induced; transcription, induced 18951090 1 0 0 inhibits S256 phosphorylation -Elk1 ELK1 DNA-binding; Transcription factor P41969 13712 X A1.3|X 16.45 cM mouse S384-p 447872 IHFWSTLsPIAPRSP molecular association, regulation; intracellular localization neural plasticity; cell differentiation, altered; cell growth, induced; transcription, induced; cytoskeletal reorganization; transcription, altered; cell growth, altered MED16(INDUCES); MED23(INDUCES); Trap100(INDUCES) DNA(INDUCES) 18160653; 18356083; 21562256; 27738173; 34704358; 35085550; 35902881; 7889942 45 1 0 -MAP4K3 KHS2 EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, STE; Protein kinase, Ser/Thr (non-receptor) Q8IVH8 8491 2p22.1 human S170-p 12655400 ATIAKRKsFIGTPYW Pkinase enzymatic activity, induced 20227368 1 3 8 -LOC100044138 SEPT5 iso2 Cell cycle regulation; Cytoskeletal; Hydrolase; Vesicle XP_001480843 100044138 mouse S17-p 475075 RLVEQLLsPRTQAQR intracellular localization 19937814 2 7 2 -ATM ATM DNA repair, damage; EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, Ser/Thr (non-receptor); Protein kinase, atypical; Tumor suppressor Q13315 472 11q22.3 human S794-p 6413900 LSNCTKKsPNKIASG phosphorylation; enzymatic activity, induced cell cycle regulation; apoptosis, induced 19151707 1 0 0 stimulates phosphorylation of S1981 -Llgl1 LLGL1 Cell adhesion; Cytoskeletal; Motility/polarity/chemotaxis Q80Y17 16897 11 B2|11 37.81 cM mouse S672-p 449918 RIRKSRVsGKKRTPA intracellular localization 11809830 2 1 0 -TP53 p53 Activator; DNA-binding; Motility/polarity/chemotaxis; Nuclear receptor co-regulator; Transcription factor; Tumor suppressor P04637 7157 17p13.1 human K381-ac 458983 GQSTSRHkKLMFKTE protein degradation; molecular association, regulation; protein stabilization; ubiquitination; intracellular localization; protein conformation apoptosis, altered; carcinogenesis, inhibited; cell growth, inhibited; apoptosis, induced; transcription, induced; transcription, altered; cell growth, induced; transcription, inhibited BCL2L2(INDUCES); PC4(INDUCES); p21Cip1(DISRUPTS); p300(INDUCES); p53(DISRUPTS) DNA(INDUCES); DNA(DISRUPTS) 11094089; 11099047; 11250899; 11971195; 12421820; 14982997; 16291740; 18485870; 19339993; 19377469; 21297583; 21586571; 22033337; 22249259; 23678107; 25651062; 31680191; 36257192; 9288740 35 6 0 promoting the C-terminal acetylation of p53 and may facilitate p53-dependent gene expression ; promotes antiviral activity; apoptosis inhibited in cortical neuron and increased in proliferating cancer cells; 20, 164, 305, 320, 370/372/373, 381/382/386 K-R mutants diminsished transactivation, and selective regulation of target genes expression through distinct mechanisms; DNA damage induces p53 acetylation and H1.2 phosphorylation, inducing disassociation and transcription leading to apoptosis or DNA repair. -Bad BAD Apoptosis O35147 64639 1q43 rat S137-p 447862 PFRGRSRsAPPNLWA Bcl-2_BAD activity, induced; molecular association, regulation apoptosis, altered; apoptosis, inhibited 14-3-3 beta(INDUCES); 14-3-3 zeta(INDUCES); Bcl-xL(DISRUPTS) 11493700; 12049737; 12807431; 19344769 124 55 216 -Arhgef26 SGEF GEF; GEF, Rac/Rho D3YYY8 622434 3|3 E1 mouse Y530-p 479144 TFDPYVKyCTNEVYQ RhoGEF molecular association, regulation cell motility, inhibited RHOG(DISRUPTS) 27437949 1 0 1 regulation of SGEF activity and function -NR4A1 Nur77 Apoptosis; DNA-binding; Nuclear receptor P22736 3164 12q13.13 human K102-sm 610814562 SPASASFkFEDFQVY protein degradation; ubiquitination transcription, inhibited 28622293 1 1 0 inhibits TNF-alpha and IL-1beta-induced NF-kB activity -FGFR1 FGFR1 EC 2.7.10.1; KINASE; Kinase, protein; Membrane protein, integral; Oncoprotein; Protein kinase, TK; Protein kinase, tyrosine (receptor) P11362 2260 8p11.23 human Y730-p 448642 SNCTNELyMMMRDCW PK_Tyr_Ser-Thr cell cycle regulation; transcription, altered 9880324 5 1 1 Phosphorylation of either Y463 or Y730, dispensable for mitogenic signaling, represents an absolute requirement for FGF2-mediated uPA induction -DVL2 DVL2 Adaptor/scaffold; Motility/polarity/chemotaxis O14641 1856 17p13.1 human S594-p 22682201 EGSRSSGsTRSDGGA Dsh_C cytoskeletal reorganization; transcription, inhibited 23396967 1 0 0 neurite outgrowth -SUZ12 SUZ12 C2H2-type zinc finger protein; Oncoprotein; Transcription factor Q15022 23512 17q11.2 human S546-p 449173 SMSEFLEsEDGEVEQ VEFS-Box molecular association, regulation; ubiquitination EZH2(DISRUPTS) 25855382 1 52 1 -ZAP70 ZAP70 EC 2.7.10.2; KINASE; Kinase, protein; Protein kinase, TK; Protein kinase, tyrosine (non-receptor) P43403 7535 2q11.2 human S520-p 2861415 FRKFSSRsDVWSYGV PK_Tyr_Ser-Thr intracellular localization; phosphorylation transcription, altered 14560012 1 0 1 increases autophosphorylation -HSPB8 HSPB8 Heat shock protein Q9UJY1 26353 12q24.23 human T87-p 467970 GVPAEGRtPPPFPGE protein conformation 21526341 2 20 0 increase chaperone activity -CASP8 CASP8 Apoptosis; EC 3.4.22.61; Protease Q14790 841 2q33.1 human K156-sm 1876540100 RVILGEGkLDILKRV DED intracellular localization 15782135 1 0 0 -PACSIN1 PACSIN1 Adaptor/scaffold Q9BY11 29993 6p21.31 human S349-p 4730488 GDRGSVSsYDRGQPY molecular association, regulation PICK1(DISRUPTS) 23918399 1 5 0 regulates AMPAR trafficking -DBI DBI Lipid-binding Q8WN94 100008823 rabbit T42-p 2833500 ATVGDVNtERPGMLD ACBP molecular association, regulation GABRA1(INDUCES) 18194441 1 0 0 -FEN1 FEN1 DNA repair, damage; DNA-binding; Deoxyribonuclease; EC 3.1.-.-; Nuclear receptor co-regulator; Nucleolus; Ribonuclease P39748 2237 11q12.2 human K354-ub 15388693 TGSLSSAkRKEPEPK protein degradation; ubiquitination 22749529 1 5 1 -BRAF BRAF EC 2.7.11.1; KINASE; Kinase, protein; Oncoprotein; Protein kinase, Ser/Thr (non-receptor); Protein kinase, TKL P15056 673 7q34 human S729-p 450242 PKIHRSAsEPSLNRA protein stabilization; molecular association, regulation; enzymatic activity, induced cell cycle regulation; cell differentiation, altered; cell growth, inhibited; cell growth, altered 14-3-3 beta(INDUCES); KSR(INDUCES); RAF1(INDUCES) 10660530; 19933846; 24095280; 31929109; 37625591 8 59 25 -KRT18 K18 Cytoskeletal; Nucleolus P05783 3875 12q13.13 human S51-p 3179064 SRISVSRsTSFRGGM intracellular localization cytoskeletal reorganization 23241311; 27403885 2 9 11 phosphorylation reduces keratin filament length, formation of connectivity-depleted and mechanically weaker networks; keratin filament buckling, S51-p is localized in the periphery of the cell. -Nfya NFYA DNA-binding; Transcription factor P23708 18044 17 C|17 23.99 cM mouse K292-ub 4664701 EAEGKIPkERRKYLH CBFB_NFYA protein degradation cell growth, inhibited; transcription, inhibited 18815279 1 0 0 -Wnk4 WNK4 EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, Other; Protein kinase, Ser/Thr (non-receptor) Q80UE6 69847 11|11 D mouse K172-ub 40323312 SPDGRYLkFDIEIGR Pkinase protein degradation 23576762 1 1 0 regulates electrolyte homeostasis and involved in Pseudohypoaldosteronism type II (PHAII) pathogenesis -Plin1 perilipin 1 Lipid-binding Q8CGN5 103968 7|7 D2 mouse S222-p 450080 PSLVRRVsTLANTLS Perilipin molecular association, regulation HSL(INDUCES) 19717842 2 6 4 -SUV39H1 SUV39H1 Amino Acid Metabolism - lysine degradation; EC 2.1.1.43; METHYLTRANSFERASE; Methyltransferase; Methyltransferase, protein lysine O43463 6839 Xp11.23 human K123-m1 63128911 NYLVQKAkQRRALRR enzymatic activity, inhibited chromatin organization, altered; cell growth, inhibited; transcription, induced 23509280 1 1 0 facilitated genomic instability -LDB1 LDB1 iso2 Transcription, coactivator/corepressor Q86U70-2 8861 10q24.32 human K365-ub 1877171202 PPSSQESkSENPTSQ protein degradation 32229578 1 0 0 -DRD1 DRD1 GPCR, family 1; Membrane protein, integral; Membrane protein, multi-pass; Receptor, GPCR P21728 1812 5q35.2 human T360-p 449796 ATNNAIEtVSINNNG receptor desensitization, altered; receptor internalization, altered 11773080 1 0 0 -L1CAM NCAM-L1 Cell adhesion; Membrane protein, integral P32004 3897 Xq28 human S1152-p 449315 RSKGGKYsVKDKEDT Bravo_FIGEY molecular association, regulation cytoskeletal reorganization; cell adhesion, inhibited ANK3(INDUCES) 17151951; 29109170; 8663493 3 1 0 L1 sensitivity to ethanol; implicated in neurite outgrowth -Net1 NET1 GEF; GEF, Rac/Rho; Motility/polarity/chemotaxis; Oncoprotein Q9Z206 56349 13|13 A1 mouse S153-p 455601 TPTKRRSsALWSEML activity, inhibited cytoskeletal reorganization 15684429 1 0 0 inhibits guanine nucleotide exhange activity toward RhoA, inhibits actin stress fiber formation -Thop1 THOP1 EC 3.4.24.15; Protease P24155 64517 7q11 rat S644-p 448213 VGMDYRTsILRPGGS Peptidase_M3 molecular association, regulation; intracellular localization; enzymatic activity, induced 14-3-3 epsilon(INDUCES) 10969067; 15773901 2 1 0 -ACTN4 ACTN4 Cytoskeletal; Motility/polarity/chemotaxis O43707 81 19q13.2 human Y265-p 450725 MTYVSSFyHAFSGAQ CH molecular association, regulation; protein processing; intracellular localization; protein conformation apoptosis, induced; cell motility, inhibited; cytoskeletal reorganization ACTB(DISRUPTS); ACTA1(INDUCES) 19920151; 23454549; 31664084 3 24 506 -Cd300a MAIR-I Immunoglobulin superfamily; Membrane protein, integral Q6SJQ0 217303 11 E2|11 80.54 cM mouse Y274-p 455227 LPQEELHySSVAFNS SIT molecular association, regulation SHIP(INDUCES); SHP-2(INDUCES); SHP-1(INDUCES) 15569773 1 0 6 -CTTN Cortactin Actin-binding; Cytoskeletal; Motility/polarity/chemotaxis Q14247 2017 11q13.3 human K161-ac 482875 YSSGFGGkYGVQADR HS1_rep molecular association, regulation; intracellular localization cell motility, inhibited ACTB(DISRUPTS) 17643370 1 2 10 Acetylation prevents localization to membrane ruf?es. -HMOX1 HMOX1 Cofactor and Vitamin Metabolism - porphyrin and chlorophyll; EC 1.14.99.3; Oxidoreductase P09601 3162 22q12.3 human K243-ac 206219703 LRQRASNkVQDSAPV molecular association, regulation carcinogenesis, induced; cell motility, induced; cell growth, induced JunD(INDUCES) 28846111 1 1 0 Interaction leads to AP-1 transcriptional activation -HTT Huntingtin Cytoskeletal P42858 3064 4p16.3 human S419-p 448106 GGRSRSGsIVELIAG activity, induced; molecular association, regulation apoptosis, induced; apoptosis, inhibited; cytoskeletal reorganization; signaling pathway regulation KIF5B(INDUCES); dynactin 1(INDUCES) 12062094; 14725621; 16452687; 18615096; 18772195; 24505464; 24619418; 32978366 14 32 21 D2R signaling; regulates mitochondrial morphology and function -PRKCI PKCI Cell adhesion; Cell development/differentiation; EC 2.7.11.13; KINASE; Kinase, protein; Motility/polarity/chemotaxis; Oncoprotein; Protein kinase, AGC; Protein kinase, Ser/Thr (non-receptor); Tumor suppressor P41743 5584 3q26.2 human T412-p 454434 RPGDTTStFCGTPNY Pkinase enzymatic activity, induced 15604232; 21281788 9 15 36 -Mob1a MOB1A Protein kinase, regulatory subunit Q921Y0 232157 6|6 C3 mouse S146-p 1214257701 PFPKNFMsVAKTILK Mob1_phocein protein degradation; ubiquitination cell growth, induced 30069702 1 0 0 induces neurite outgrowth and regulates functional recovery after SCI -SARS1 SARS Aminoacyl-tRNA synthetase; EC 6.1.1.11; Ligase; RNA processing; Translation; Translation regulation P49591 6301 1p13.3 human S241-p 482693 MQEVAQLsQFDEELY molecular association, regulation carcinogenesis, induced; cell growth, induced; transcription, induced DNA(DISRUPTS) 33351793 1 1 0 -Nfatc2 NFAT1 DNA-binding; Transcription factor Q60591 18019 2 H3|2 88.91 cM mouse K684-ub 1852795101 YHPVPAIkTEPSDEY protein degradation 21628454 1 0 0 in NFAT1 S215/219/223A triple mutant or when phosphorylation of those sites is inhibited by zoledronic acid -PITX1 PITX1 Cell development/differentiation; DNA-binding; Transcription factor P78337 5307 5q31.1 human Y179-p 54204603 EDVYAAGySYNNWAA protein degradation; protein stabilization transcription, inhibited 26840794; 27752061 2 0 0 -BCL2L1 Bcl-xL Apoptosis; Autophagy; Membrane protein, integral; Mitochondrial Q07817 598 20q11.21 human S49-p 21336504 ESEMETPsAINGNPS protein conformation cell cycle regulation; cell growth, inhibited 21840391; 27398719; 28486788 3 0 0 growth inhibited in both SA and SD mutants; stabilizes G2 arrest; enables cytokinesis and mitotic exit -APBB1 Fe65 Adaptor/scaffold; Apoptosis; Transcription regulation O00213 322 11p15.4 human S228-p 36841900 DSSWATLsQGSPSYG transcription, inhibited 25397632 2 0 0 inhibits transcriptional activity of APP in the Fe65-APP complex -Ywhaz 14-3-3 zeta Adaptor/scaffold; Motility/polarity/chemotaxis P63101 22631 15|15 B3.1 mouse Y179-p 7316700 LNFSVFYyEILNSPE 14-3-3 molecular association, regulation; phosphorylation SHC1(INDUCES) 19218246 1 1 0 important for the phosphorylation of Akt and cytokine-mediated cell survival -Ubtf UBF DNA-binding; Nucleolus; Transcription factor P25977 25574 10q32.1 rat T117-p 448504 DFPKKPLtPYFRFFM HMG_box transcription, inhibited 11741541 1 6 13 -TUSC2 TUSC2 Tumor suppressor O75896 11334 3p21.31 human K71-ub 1881852004 YEETIVTkNGQKRAK protein degradation apoptosis, induced 35167936 1 0 0 TUSC2-K71R significantly increased GSC-28 neurosphere apoptosis compared to WT -NUP98 NUP98 iso2 Motility/polarity/chemotaxis; Nucleoporin P52948-2 4928 11p15.4 human S861-p 18330804 GSWVFKVsHFSKYGL Nucleoporin2 intracellular localization 21335236 1 1 0 as multiple sites (13PM) mutant -Il4r IL4R Membrane protein, integral; Receptor, cytokine P16382 16190 7 F3|7 68.94 cM mouse Y500-p 451065 VLADNPAyRSFSDCC activity, induced; phosphorylation cell cycle regulation 14557412; 16210622 3 0 0 Akt and p70S6K phosphorylation -SALL4 SALL4 iso3 C2H2-type zinc finger protein; Cancer Testis Antigen (CTA); DNA-binding Q9UJQ4-2 57167 20q13.2 human K156-sm 31089512 AESVVYLkTETALPP protein stabilization; molecular association, regulation; intracellular localization transcription, induced Oct4(DISRUPTS) 23012367 1 0 0 -Ppargc1b PGC-1 beta Nuclear receptor co-regulator; Transcription, coactivator/corepressor Q8VHJ7 170826 18|18 E1 mouse K469-ac 7761209 PWTKLGRkMDSSVCP intracellular localization transcription, inhibited 19491097 1 1 0 -Mlxipl ChREBP Transcription factor Q99MZ3 58805 5|5 G2 mouse K672-ac 18609101 THISAEQkRRFNIKL HLH molecular association, regulation transcription, induced DNA(INDUCES) 25761756 2 0 0 -ILF3 NFAT90 DNA-binding; Nucleolus; RNA-binding; Transcription factor Q12906 3609 19p13.2 human S482-p 449210 DSSKGEDsAEETEAK protein stabilization cell cycle regulation 21401756 1 41 10 -IRAK4 IRAK4 EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, Ser/Thr (non-receptor); Protein kinase, TKL Q9NWZ3 51135 12q12 human T342-p 2045344 ASEKFAQtVMTSRIV PK_Tyr_Ser-Thr enzymatic activity, induced 17141195; 17312103 3 3 0 -NAA50 NAA50 ACETYLTRANSFERASE; Acetyltransferase; EC 2.3.1.- Q9GZZ1 80218 3q13.31 human K37-ac 461832 SYNDKFYkDVLEVGE Acetyltransf_1 acetylation; enzymatic activity, induced 19744929 1 8 63 reduces histone acetylation and increases NAT activity, thereby increasing enzyme specificity -DUSP4 DUSP4 EC 3.1.3.16; EC 3.1.3.48; PHOSPHATASE; Protein phosphatase, dual-specificity Q13115 1846 8p12 human S386-p 15412243 SSLPYLHsPITTSPS protein stabilization 25204653 2 1 2 -RPS3 RPS3 Apoptosis; EC 4.2.99.18; RNA-binding; Ribosomal; Translation P23396 6188 11q13.4 human T221-p 452652 KDEILPTtPISEQKG activity, induced; intracellular localization translation, altered 19059439; 21871177 4 100 99 nuclear accumulation; important for a cell survival in the stress condition -BLNK BLNK Adaptor/scaffold Q8WV28 29760 10q24.1 human Y189-p 447717 VEDNDENyIHPTESS molecular association, regulation transcription, altered PLCG1(INDUCES); Btk(INDUCES); NCK2(INDUCES); VAV1(INDUCES) 12456653 1 2 4 Sites mutated alone and in combination (Y189,Y178and Y96) prevented binding of PLCG1 and mobization of Ca2+. For NF-AT transcriptional activity Y103,Y194 and Y205 residues were necessary.Tyrosine phosphoryation of BLNK induces MAPK activation. -Pgk1 PGK1 Carbohydrate Metabolism - glycolysis and gluconeogenesis; EC 2.7.2.3; KINASE; Kinase, other P09411 18655 X D|X 47.36 cM mouse S203-p 468410 YFAKALEsPERPFLA PGK signaling pathway regulation 36963288 3 83 11 regulates the Keap1-Nrf2 signaling pathway -Plk4 PLK4 EC 2.7.11.21; KINASE; Kinase, protein; Nucleolus; Protein kinase, Other; Protein kinase, Ser/Thr (non-receptor) Q64702 20873 3|3 B mouse T293-p 12654011 GHATLSTtITASSGT protein degradation; ubiquitination 20100909 1 1 0 -CXADR CXADR Cell adhesion; Membrane protein, integral; Receptor, misc. P78310 1525 21q21.1 human T290-p 801662702 PPKSRTStARSYIGS molecular association, regulation; intracellular localization KIF22(INDUCES) 29382784 1 0 0 translocation within cell junctions in response to EGF -PAX3 PAX3 DNA-binding; Oncoprotein; Transcription factor P23760 5077 2q36.1 human S201-p 18744500 ERASAPQsDEGSDID cell growth, inhibited; cell motility, inhibited 25821947 4 2 0 -Scrib Scribble iso3 Cell adhesion; Motility/polarity/chemotaxis Q80U72-3 105782 15 D3|15 35.29 cM mouse S1601-p 449228 RPVYDIQsPDFVEEL molecular association, regulation; intracellular localization cell adhesion, altered CDH1(DISRUPTS) 21146521 1 47 6 interaction with E-cadherin-catenin complex -FOXO1 FOXO1A DNA-binding; Nuclear receptor co-regulator; Oncoprotein; Transcription factor Q12778 2308 13q14.11 human S22-p 1869008600 EPLPRPRsCTWPLPR activity, induced; molecular association, regulation; intracellular localization; phosphorylation transcription, altered; transcription, inhibited; signaling pathway regulation 14-3-3 beta(DISRUPTS) 31308176; 34646017 2 1 0 -Arhgap35 GRF-1 GAP; GAP, Rac/Rho; Motility/polarity/chemotaxis; Transcription factor; Tumor suppressor Q91YM2 232906 7|7 A2 mouse Y308-p 455312 ASPEYQDyVYLEGTQ RhoGAP-FF1 molecular association, regulation GTF2I(DISRUPTS) 15629714 2 0 0 -Nrip1 RIP140 Nuclear receptor co-regulator; Transcription, coactivator/corepressor Q8CBD1 268903 16|16 C3.1 mouse K591-me 6742801 ACSTPASkLTNTAPS NRIP1_repr_2 molecular association, regulation; methylation transcription, inhibited HDAC3(INDUCES) 19216533 1 1 0 inhibits arginine methylation -Rb1 Rb Nuclear receptor co-regulator; Oncoprotein; Transcription, coactivator/corepressor; Tumor suppressor P13405 19645 14 38.73 cM|14 D3 mouse T350-p 447981 DSFETERtPRKNNPD molecular association, regulation cell cycle regulation; cell growth, induced; transcription, inhibited E2F1(DISRUPTS) 10207050; 35023164; 9671466 15 19 36 transcriptional downregulation of the E2F-1, E2F-2, dihydrofolate reductase, thymidine kinase, c-myc, proliferating-cell nuclear antigen, p107, and p21/Cip1 genes -Mapk14 P38A EC 2.7.11.24; KINASE; Kinase, protein; Protein kinase, CMGC; Protein kinase, Ser/Thr (non-receptor) P70618 81649 20p12 rat Y182-p 447971 TDDEMTGyVATRWYR Pkinase activity, induced; enzymatic activity, induced apoptosis, induced; cell growth, altered 10473611; 25371038; 28039298 410 123 3683 -Foxo4 FOXO4 DNA-binding; Oncoprotein; Transcription factor Q9WVH3 54601 X D|X 43.89 cM mouse S197-p 448516 APRRRAAsMDSSSKL molecular association, regulation transcription, altered 14-3-3 zeta(INDUCES) 14690436 13 5 6 -OPN3 encephalopsin GPCR, family 1; Membrane protein, integral; Membrane protein, multi-pass; Receptor, GPCR Q9H1Y3 23596 1q43 human Y140-p 23257062 TVLAYERyIRVVHAR 7tm_1 carcinogenesis, induced 35180853 1 0 1 -RPL36A RPL36A P83881 6173 Xq22.1 human K53-m1 8106909 SGYGGQTkPIFRKKA Ribosomal_L44 molecular association, regulation ETF1(INDUCES) 28567122 1 6 36 -UVRAG UVRAG Autophagy Q9P2Y5 7405 11q13.5 human K559-ub 3937122 DTSLDFSkENKKKGE autophagy, induced 30686098 1 0 1 -RNF2 RNF2 EC 6.3.2.-; EC 6.3.2.19; Ligase; UBIQUITIN LIGASE; Ubiquitin conjugating system; Ubiquitin ligase Q99496 6045 1q25.3 human S41-p 7670101 DGLEIVVsPRSLHSE transcription, altered 19405034 1 15 2 -Lipe HSL EC 3.1.1.79; Lipase P54310 16890 7 A3|7 13.78 cM mouse S559-p 448804 ESMRRSVsEAALAQP phosphorylation 19942859 27 28 1 inhibits phosphorylation at S557 -RALA RALA G protein; G protein, monomeric; G protein, monomeric, Ras; Motility/polarity/chemotaxis P11233 5898 7p14.1 human S194-p 483989 NGKKKRKsLAKRIRE molecular association, regulation; intracellular localization; enzymatic activity, induced carcinogenesis, induced; cell growth, induced; cytoskeletal reorganization; cell growth, altered RALBP1(NOT_REPORTED) 17540176; 19901077 5 1 1 localization to plasma membrane -PARD6A PARD6A Adaptor/scaffold; Cell adhesion; Motility/polarity/chemotaxis Q9NPB6 50855 16q22.1 human S345-p 15714600 RGDGSGFsL______ protein degradation cell motility, induced; cytoskeletal reorganization 23249950 2 9 0 phosphorylation necessary to induce Epithelial to mesenchymal transition (EMT) and RhoA degradation, TGF? induced E-cadherin loss, stress fiber formation -Per2 PER2 Nuclear receptor co-regulator; Nucleolus; Transcription factor O54943 18627 1|1 D mouse S478-p 50596800 PVPHSGSsGYGSLGS protein degradation; molecular association, regulation BTRC(INDUCES) 26431025; 28545154 4 0 0 -Ube2j1 UBE2J1 EC 6.3.2.19; Membrane protein, integral; UBIQUITIN LIGASE; Ubiquitin conjugating system; Ubiquitin ligase Q9JJZ4 56228 4|4 A5 mouse S184-p 465537 KELARQIsFKAEVNS translation, induced 24020373 3 13 52 TNF-alpha synthesis -POLH POLH DNA repair, damage; EC 2.7.7.7; Transferase Q9Y253 5429 6p21.1 human S587-p 5024701 GVSKLEEsSKATPAE intracellular localization DNA repair, induced; cell growth, altered 18946034; 35339488 2 0 0 -MRE11 MRE11A Cell cycle regulation; DNA repair, damage; DNA-binding; Deoxyribonuclease P49959 4361 11q21 human S531-p 5846030 TRARALRsQSEESAS molecular association, regulation DNA(DISRUPTS) 19709933 1 0 1 -LIG1 LIG1 DNA repair, damage; EC 6.5.1.1; Ligase P18858 3978 19q13.33 human S66-p 448498 KAARVLGsEGEEEDE molecular association, regulation; intracellular localization cell growth, altered RFC1(INDUCES); RAD17(DISRUPTS) 12851383; 19223468 4 54 6 regulates DNA replication and repair -BMX Etk EC 2.7.10.2; KINASE; Kinase, protein; Protein kinase, TK; Protein kinase, tyrosine (non-receptor) P51813 660 Xp22.2 human Y40-p 448066 LTKTNLSyYEYDKMK PH molecular association, regulation; intracellular localization; enzymatic activity, induced cell motility, altered; cytoskeletal reorganization FAK(INDUCES) 11331870 5 0 0 -Hnrnpa3 hnRNP A3 RNA splicing; RNA-binding; Spliceosome Q8BG05 229279 2|2 C3 mouse S359-p 483226 FGGRSSGsPYGGGYG molecular association, regulation RNA(DISRUPTS) 20885981 1 78 82 -Chek1 Chk1 EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, CAMK; Protein kinase, Ser/Thr (non-receptor); Tumor suppressor O35280 12649 9|9 A4 mouse S286-p 465527 TSGGMSEsSSGFSKH intracellular localization 19837665 5 12 14 -REL REL Oncoprotein; Transcription factor Q04864 5966 2p16.1 human S503-p 453447 VNMMTTSsDSMGETD apoptosis, inhibited; transcription, induced; transcription, altered 10823840; 16027730 2 0 0 S503A mutation enhances REL's transforming activity in vitro, while S503D mutation inhibits it. -ACKR3 CMKOR1 GPCR, family 1; Membrane protein, integral; Membrane protein, multi-pass; Receptor, GPCR P25106 57007 2q37.3 human S355-p 4709319 RVSETEYsALEQSTK receptor internalization, induced; molecular association, regulation; intracellular localization ARRB1(INDUCES) 33799570 1 6 7 -Cdkn2c CDKN2C Cell cycle regulation; Inhibitor; Protein kinase, regulatory subunit Q60772 12580 4 C7|4 51.32 cM mouse K46-ub 6423506 RTALQVMkLGNPEIA protein degradation 19029828 1 0 5 -PTPN11 SHP-2 iso1 EC 3.1.3.48; Motility/polarity/chemotaxis; PHOSPHATASE; Protein phosphatase, tyrosine (non-receptor) Q06124-1 5781 12q24.13 human K594-sm 40709500 VGLMQQQkSFR____ molecular association, regulation; intracellular localization; phosphorylation carcinogenesis, induced; signaling pathway regulation GAB1(INDUCES) 25823821 1 0 0 induces ERK phosphorylation, regulates ERK signaling pathway -Trpv1 TRPV1 Channel, cation; Membrane protein, integral; Membrane protein, multi-pass; Receptor, misc. O35433 83810 10q24 rat S800-p 450017 VPLLRDAsTRDRHAT activity, induced; receptor desensitization, inhibited; molecular association, regulation; receptor desensitization, altered cytoskeletal reorganization TUBA1A(DISRUPTS) 12761211; 14523239; 14973326; 15003856; 18001466; 18391945; 18495351; 21480900; 22933780; 25451626; 32345612 21 0 0 -Igf1r IGF1R EC 2.7.10.1; KINASE; Kinase, protein; Membrane protein, integral; Protein kinase, TK; Protein kinase, tyrosine (receptor) Q60751 16001 7 C|7 37.27 cM mouse Y1163-p 448386 FGMTRDIyETDYYRK PK_Tyr_Ser-Thr intracellular localization; enzymatic activity, induced cell cycle regulation; cell growth, induced; cell differentiation, induced; cell motility, altered 18515860; 23954591; 34158399; 8940173 22 31 455 -ATP5F1A ATP5A1 EC 3.6.3.14; Energy Metabolism - oxidative phosphorylation; Hydrolase; Membrane protein, integral; Mitochondrial; Transporter P25705 498 18q21.1 human Y246-p 477314 KKKLYCIyVAIGQKR ATP-synt_ab molecular association, regulation; phosphorylation carcinogenesis, induced; cell growth, induced; apoptosis, inhibited; autophagy, inhibited ATPIF1(DISRUPTS) 35895804 1 1 2 inhibits phosphorylation of downstream proteins -Prkn PARK2 EC 6.3.2.-; EC 6.3.2.19; Ligase; Translation; Translation regulation; UBIQUITIN LIGASE; Ubiquitin conjugating system; Ubiquitin ligase Q9WVS6 50873 17 A1|17 7.8 cM mouse S131-p 454421 DTDSKRDsEAARGPV protein stabilization; ubiquitination; enzymatic activity, inhibited 32379419 5 3 0 decrease DMT1 ubiquitination and increase DMT1 protein stabilization -CEBPE C/EBP-epsilon DNA-binding; Motility/polarity/chemotaxis; Transcription factor Q15744 1053 14q11.2 human K198-ac 38557702 GPLHKGKkAVNKDSL cell differentiation, induced; transcription, induced 25568349; 31256937 2 1 0 deletion of R247 or S248 was sufficient for the loss of C/EBPe transcriptional activity, TSA treatment may be able restore the transcriptional activity -Htr1a 5-HT(1A) GPCR, family 1; Membrane protein, integral; Membrane protein, multi-pass; Receptor, GPCR P19327 24473 2q13 rat T149-p 467261 IDYVNKRtPRRAAAL 7tm_1 receptor desensitization, induced; receptor inactivation, altered 11773315; 23510743 2 0 0 -ATF6 ATF6A Membrane protein, integral; Transcription factor P18850 22926 1q23.3 human T166-p 35527100 NKTENGLtPKKKIQV protein degradation; molecular association, regulation; intracellular localization cell cycle regulation; autophagy, induced; cell differentiation, induced; transcription, induced EBP(INDUCES) DNA(INDUCES) 25135476; 37239128 2 2 0 -CENPQ CENPQ Q7L2Z9 55166 6p12.3 human S139-p 31868909 EDLTNVSsLLNMERA CENP-Q molecular association, regulation; intracellular localization DNA(DISRUPTS) 25670858 1 1 0 CENPQ phosphorylation promotes the delocalization of the PBIP1-CENPQ complex from kinetochores -Adcy2 ADCY2 Adenylyl cyclase; EC 4.6.1.1; Lyase; Membrane protein, integral; Membrane protein, multi-pass; Nucleotide Metabolism - purine; Transporter; Transporter, aquaporin family P26769 81636 1p11 rat S871-p 451125 AEHFLARsLKNEELY activity, induced 9366262 1 0 0 -KDM5B JARID1B Cancer Testis Antigen (CTA); DEMETHYLASE; Demethylase; EC 1.14.11.-; Oxidoreductase; Transcription, coactivator/corepressor Q9UGL1 10765 1q32.1 human K278-sm 31089529 KEMKSSIkQEPIERK molecular association, regulation; enzymatic activity, induced transcription, induced DNA(DISRUPTS) 23970103 1 1 0 regulates JARID1B demethylase activity -PKP1 plakophilin 1 Cell adhesion; Motility/polarity/chemotaxis Q13835 5317 1q32.1 human S174-p 27717303 LRKGTLGsKGQKTTQ activity, induced; protein stabilization cell motility, induced; cell growth, induced; translation, induced; cell adhesion, inhibited 23444369 1 1 0 -DTNBP1 DTNBP1 Vesicle Q96EV8 84062 6p22.3 human S299-p 40721501 RAKPPSSsSTCTDSA Dysbindin protein degradation; ubiquitination cell growth, inhibited; transcription, inhibited 30062698 1 1 0 phosphorylation inhibits cofilin transcription and does not reduce surface NR2A levels -Pdcl PhLP G protein regulator, misc. Q63737 64013 3q11 rat S20-p 448825 LQYYYSTsEDEDSDH activity, inhibited 12466282 4 6 3 -SMAD1 SMAD1 DNA-binding; Transcription factor Q15797 4086 4q31.21 human S462-p 448361 GSPHNPIsSVS____ activity, induced; molecular association, regulation; intracellular localization transcription, altered SMAD4(INDUCES) 9136927; 9335504 2 4 4 -BSG BSG Immunoglobulin superfamily; Membrane protein, integral P35613 682 19p13.3 human K366-ub 12324673 DAGSAPLkSSGQHQN carcinogenesis, induced; cell motility, induced; cell growth, induced; transcription, induced 26769849 1 4 8 -CDC25B CDC25B EC 3.1.3.48; Motility/polarity/chemotaxis; Nuclear receptor co-regulator; PHOSPHATASE; Protein phosphatase, dual-specificity P30305 994 20p13 human S353-p 452008 VQNKRRRsVTPPEEQ M-inducer_phosp cell cycle regulation 15128871; 16082213; 23708659 8 13 9 -ZNF746 PARIS C2H2-type zinc finger protein; Transcription regulation Q6NUN9 155061 7q36.1 human K189-sm 580826722 PDLLMQIkQEGELQL transcription, inhibited 31856708; 33077496 2 2 0 -Wnk1 WNK1 EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, Other; Protein kinase, Ser/Thr (non-receptor) P83741 232341 6|6 F1 mouse S378-p 456474 LATLKRAsFAKSVIG Pkinase phosphorylation; enzymatic activity, induced 34289367 3 7 0 induces NKCC1 phosphorylation -Sod2 SOD2 EC 1.15.1.1; Mitochondrial; Oxidoreductase P09671 20656 17 A1|17 8.75 cM mouse K122-me 1872904400 GELLEAIkRDFGSFE Sod_Fe_C cell cycle regulation 22710435 1 1 0 quiescent fibroblasts are dimethylated at K122, and R197 and are also dimethylated in proliferating cells -WASF2 WAVE2 Actin-binding; Motility/polarity/chemotaxis Q9Y6W5 10163 1p36.11 human S351-p 18715500 PGTPPPPsPPSFPPH molecular association, regulation cell motility, altered; cytoskeletal reorganization 21419341 3 0 0 regulates WRC (WAVE2 regulatory complex) interaction with Arp2/3 and lamellipodial protrusion -PIK3AP1 BCAP Adaptor/scaffold Q9DDT2 374268 chicken Y463-p 449909 PGAPEDLyVEMLQSK molecular association, regulation PIK3R1(INDUCES) 11163197 2 0 0 -Stat3 STAT3 DNA-binding; Motility/polarity/chemotaxis; Nuclear receptor co-regulator; Transcription factor P42227 20848 11 D|11 63.82 cM mouse Y705-p 448192 DPGSAAPyLKTKFIC activity, induced; acetylation; molecular association, regulation; ubiquitination; intracellular localization; phosphorylation cell cycle regulation; carcinogenesis, induced; carcinogenesis, inhibited; carcinogenesis, altered; apoptosis, induced; cell growth, inhibited; cell motility, induced; transcription, induced; signaling pathway regulation; transcription, altered; cell differentiation, induced; cell growth, induced; apoptosis, inhibited; transcription, inhibited; cell growth, altered PDGFRA(INDUCES); SIRT1(INDUCES); STAT3(INDUCES) DNA(INDUCES) 11278353; 11751994; 12684046; 15218058; 15705584; 15852015; 15923602; 16205632; 16247467; 18795895; 19295512; 20185553; 21575863; 24526685; 25119572; 25584415; 26479789; 26675719; 26923837; 30573679; 31924651; 31934850; 32475380; 33323974; 33539470; 33664496; 33947971; 33972660; 33985537; 34038731; 34117031; 34168048; 34380027; 34404751; 34530865; 35145233; 35411090; 35732128; 35756080; 35806005; 36088505; 36179418; 36400972; 36450257; 36688918; 36934646; 36976181; 37370133; 9234724; 9531474 541 75 3065 -CASP8 CASP8 iso4 Apoptosis; EC 3.4.22.61; Protease Q14790-4 841 2q33.1 human Y397-p 460647 TDSEEQPyLEMDLSS Peptidase_C14 enzymatic activity, induced 27101103 10 3 35 Src activated by CASP8 Y397 and Y465 phosphorylation -FERMT2 kindlin-2 Cytoskeletal; Motility/polarity/chemotaxis Q96AC1 10979 14q22.1 human S186-p 15226813 YSSPGLYsKTMTPTY protein degradation; molecular association, regulation; ubiquitination cell cycle regulation; cell growth, induced; apoptosis, inhibited; cytoskeletal reorganization; cell adhesion, inhibited CUL9(INDUCES) 35469017 1 2 1 -MCL1 MCL1 Apoptosis; Channel, misc.; Inhibitor; Membrane protein, integral; Mitochondrial Q07820 4170 1q21.2 human T92-p 4825134 EVPDVTAtPARLLFF protein degradation; protein stabilization; molecular association, regulation; ubiquitination cell cycle regulation; apoptosis, altered; carcinogenesis, inhibited; apoptosis, induced; cell growth, altered PIN1(INDUCES) 18676833; 20526282; 21368834; 26205817; 26219338; 27738316; 28751497 7 3 2 -SLC9A1 NHE1 Membrane protein, integral; Membrane protein, multi-pass; Motility/polarity/chemotaxis; Transporter; Transporter, SLC family P19634 6548 1p36.11 human S648-p 3880766 KTRQRLRsYNRHTLV NEXCaM_BD molecular association, regulation; activity, inhibited Calmodulin(DISRUPTS) 18757828; 33655882 4 2 6 -Kcnd2 Kv4.2 Channel, potassium; Membrane protein, integral; Membrane protein, multi-pass Q63881 rat S459-p 2906104 LLSNQLQsSEDEPAF protein stabilization 15071113 1 0 0 -CDC14A CDC14A EC 3.1.3.16; EC 3.1.3.48; Motility/polarity/chemotaxis; PHOSPHATASE; Protein phosphatase, dual-specificity Q9UNH5 8556 1p21.2 human S429-p 5276069 KGHPRAVsQPFRLSS phosphorylation cell cycle regulation 31722221 1 1 1 induces phosphorylation of its substrates by inhibiting its activity -NHE-3 NHE3 Membrane protein, integral; Membrane protein, multi-pass; Transporter; Transporter, SLC family P26432 100009430 rabbit S554-p 450899 TEGERRGsLAFIRSP intracellular localization; activity, inhibited 25480791 27 5 4 decreased surface expression of NHE3, phosphorylation of this site with other 2 sites are together necessary for activity inhibition -POU5F1 Oct4 DNA-binding; Transcription factor Q01860 5460 6p21.33 human K222-me 1881459302 ENLQEICkAETLVQA protein degradation cell differentiation, inhibited; transcription, inhibited 33986438 1 1 0 proteasome-independent degradation; represses the transcription of PORE-motif-containing target genes in vivo and the differentiation capacity of PSCs -CELF1 CELF1 Cell development/differentiation; RNA processing; RNA-binding Q92879 10658 11p11.2 human S241-p 29668004 LLQQTASsGNLNTLS RNA splicing, altered 24151077 1 1 0 splicing regulation in diabetes -NCOA3 SRC-3 ACETYLTRANSFERASE; Acetyltransferase; EC 2.3.1.48; Motility/polarity/chemotaxis; Nuclear receptor co-regulator; Transcription, coactivator/corepressor Q9Y6Q9 8202 20q13.12 human T1059-p 4252801 ALLDQLHtLLSNTDA Nuc_rec_co-act protein stabilization; molecular association, regulation PSMA3(DISRUPTS) 18313384 1 0 0 some subset of these 8 residues -Ldhb LDH-B Amino Acid Metabolism - cysteine and methionine; Carbohydrate Metabolism - glycolysis and gluconeogenesis; Carbohydrate Metabolism - propanoate; Carbohydrate Metabolism - pyruvate; EC 1.1.1.27; Oxidoreductase P16125 16832 6 G2|6 74.17 cM mouse K82-ac 466168 TPKIVADkDYSVTAN Ldh_1_N enzymatic activity, inhibited 33248168 2 6 3 inhibited lactate clearance -FUS hnRNP P2 DNA-binding; Nuclear receptor co-regulator; Oncoprotein; RNA splicing; RNA-binding; SUMO LIGASE P35637 2521 16p11.2 human S54-p 283458502 TSGYGQSsYSSYGQS molecular association, regulation 28942918 1 1 0 strongly reduced the effects of DNA-PK treatment on both hydrogel binding and droplet formation -THRB TR-beta1 DNA-binding; Nuclear receptor P10828 7068 3p24.2 human K443-sm 27490402 ASRFLHMkVECPTEL Hormone_recep molecular association, regulation; intracellular localization cell growth, induced; cell differentiation, induced; transcription, induced; signaling pathway regulation; transcription, altered N-CoR1(DISRUPTS); CBP(DISRUPTS); Src(INDUCES); N-CoR1(INDUCES) DNA(INDUCES); DNA(DISRUPTS) 22930759; 25572392; 27843805 3 0 0 -EGFR EGFR EC 2.7.10.1; KINASE; Kinase, protein; Membrane protein, integral; Oncoprotein; Protein kinase, TK; Protein kinase, tyrosine (receptor) P00533 1956 7p11.2 human K970-ub 1065301 ELIIEFSkMARDPQR receptor recycling, inhibited; protein degradation 16543144; 17940017 2 4 0 -NCOR2 SMRT Nuclear receptor co-regulator; Transcription, coactivator/corepressor Q9Y618 9612 12q24.31 human S2426-p 6422852 ASGDRPPsVSSVHSE protein degradation; ubiquitination; intracellular localization transcription, induced; signaling pathway regulation 22888005 1 1 0 activates Notch1 signaling in intact cells -Ppp1r1b DARPP-32 Motility/polarity/chemotaxis; Protein phosphatase, regulatory subunit Q6J4I0 360616 10q31 rat T75-p 448048 RPNPCAYtPPSLKAV DARPP-32 transcription, altered 15066157 38 6 16 Cocaine sensitized rats showed increased phosphorylation at T75 and decreased at T34, as well as increased Cdk5 expression. -AKT1 Akt1 EC 2.7.11.1; KINASE; Kinase, protein; Oncoprotein; Protein kinase, AGC; Protein kinase, Ser/Thr (non-receptor) P31749 207 14q32.33 human K20-ac 1874844900 HKRGEYIkTWRPRYF PH enzymatic activity, inhibited signaling pathway regulation 28462918; 34965411 3 0 0 activation of dynamin-related protein 1 (DRP1), metabolic reprogramming, glycolytic switching -CDC37 CDC37 Chaperone Q16543 11140 19p13.2 human Y4-p 34490407 ____MVDySVWDHIE CDC37_N molecular association, regulation 22727666 1 0 0 -PAK2 PAK2 EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, STE; Protein kinase, Ser/Thr (non-receptor) Q13177 5062 3q29 human T134-p 15413019 LKFYDSNtVKQKYLS phosphorylation cell cycle regulation; carcinogenesis, induced; cell growth, induced; signaling pathway regulation 32483448 1 5 8 induces phosphorylation of mEK and ERK, induces MAPK signaling pathway -EDNRA EDNRA GPCR, family 1; Membrane protein, integral; Membrane protein, multi-pass; Motility/polarity/chemotaxis; Receptor, GPCR P25101 1909 4q31.22-q31.23 human S393-p 2911710 CCCYQSKsLMTSVPM receptor desensitization, induced 24064210 1 1 0 Lack of S397, T403 and S404 influences desensitization to a greater extent compared than S391, S393, and T396 -Nefl NFL Cytoskeletal P08551 18039 14|14 D1 mouse S42-p 457402 TARSAYSsYSAPVSS Filament_head molecular association, regulation; intracellular localization 14-3-3 gamma(INDUCES) 23230147 3 0 1 regulates NF-L dynamic exchange rate and neurofilament disassembly -MDM2 MDM2 EC 6.3.2.-; EC 6.3.2.19; Inhibitor; Ligase; NEDDYLATION LIGASE; Neddylation Ligase; Nucleolus; Oncoprotein; UBIQUITIN LIGASE; Ubiquitin conjugating system; Ubiquitin ligase Q00987 4193 12q15 human T158-p 27620700 HLVSRPStSSRRRAI protein degradation 23132866 1 0 0 increases MDM2 association with AR via Ser-186 -MDM4 MDM4 EC 6.3.2.-; Ligase; UBIQUITIN LIGASE; Ubiquitin conjugating system; Ubiquitin ligase O15151 4194 1q32.1 human S289-p 456471 DDLEDSKsLSDDTDV molecular association, regulation transcription, inhibited p53(INDUCES); MDM2(INDUCES) 16024788; 23028042; 27114532 5 0 0 -BECN1 beclin 1 Adaptor/scaffold; Autophagy; Membrane protein, peripheral Q14457 8678 17q21.31 human K437-ac 63237403 KFMLTNLkWGLAWVS APG6 protein stabilization; molecular association, regulation; acetylation carcinogenesis, inhibited; autophagy, induced; cell growth, induced; apoptosis, inhibited; autophagy, inhibited rubicon(INDUCES) 26008601; 29088823 2 2 0 CK1 phosphorylation primes for Beclin 1 acetylation; aspirin treatment -TVB5 TVB5 P04213 mouse S78-p 25573800 GYKASRPsQENFSLI V-set activity, induced 12680588 1 0 0 IL-2 secretion in response superantigen staphylococcal enterotoxin B (SEB) binding -Grik2 GluR6 Channel, calcium; Channel, ligand-gated; Membrane protein, integral; Membrane protein, multi-pass P39087 14806 10 B3|10 24.87 cM mouse S868-p 478417 MVEELRMsLKCQRRL intracellular localization 19920140 7 0 0 -PAK1 PAK1 EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, STE; Protein kinase, Ser/Thr (non-receptor) Q13153 5058 11q13.5-q14.1 human S199-p 448172 PRPEHTKsVYTRSVI intracellular localization; protein conformation; enzymatic activity, induced cell motility, altered; cell adhesion, altered 19574218 16 0 0 recruitment to the plasma membrane -EMD emerin Cytoskeletal; Membrane protein, integral P50402 2010 Xq28 human Y4-p 3071455 ____MDNyADLSDTE LEM molecular association, regulation BAF(DISRUPTS) 19789182 1 2 1 -CALR Calreticulin ACETYLTRANSFERASE; Acetyltransferase; Calcium-binding; Motility/polarity/chemotaxis; Nuclear receptor co-regulator; Secreted; Secreted, signal peptide P27797 811 19p13.13 human K64-ac 4219814 YGDEEKDkGLQTSQD Calreticulin protein conformation 18795239 1 1 0 -Bad BAD Apoptosis Q61337 12015 19|19 A mouse S155-p 447863 GRELRRMsDEFEGSF Bcl-2_BAD molecular association, regulation; intracellular localization apoptosis, altered; apoptosis, inhibited 14-3-3 gamma(INDUCES); Bcl-xL(DISRUPTS) 10837473; 10837486; 10880354; 10949026; 10996800; 11114542; 11717309; 12754297; 12944463; 15123689; 17535812; 20043968; 22103330; 23332762; 25640178 47 63 166 glucokinase activation, protection of islet survival -GYS1 GYS1 Carbohydrate Metabolism - starch and sucrose; EC 2.4.1.11; Transferase P13807 2997 19q13.33 human S723-p 4787599 SSSLSTPsEPLSPTS phosphorylation 34758018 1 4 0 primes phopshorylation at S641 -MARK2 MARK2 EC 2.7.11.1; EC 2.7.11.26; KINASE; Kinase, protein; Protein kinase, CAMK; Protein kinase, Ser/Thr (non-receptor) Q7KZI7 2011 11q13.1 human S409-p 3245780 NPKQRRFsDQAAGPA enzymatic activity, inhibited neural plasticity; cytoskeletal reorganization 25512381 1 29 3 1) PKAC inhibits phosphorylation of Tau caused by MARK-2. 2) PKAC acts as a negative regulator of MARK-2 in regulating microtubule stability and neurite outgrowth. -Lck Lck EC 2.7.10.2; KINASE; Kinase, protein; Oncoprotein; Protein kinase, TK; Protein kinase, tyrosine (non-receptor) P06240 16818 4 D2.2|4 63.26 cM mouse Y192-p 447821 NLDNGGFyISPRITF SH2 molecular association, regulation; enzymatic activity, inhibited; protein conformation; phosphorylation cell differentiation, inhibited; signaling pathway regulation CD45(DISRUPTS) 28735895; 35806279 5 29 1070 induces TCR signaling but inhibits ERK phosphorylation -WWOX WWOX Apoptosis; EC 1.1.1.-; Oxidoreductase; Tumor suppressor Q9NZC7 51741 16q23.1-q23.2 human Y287-p 457684 LSPTKNDyWAMLAYN protein degradation cell cycle regulation 16288044; 24899407 4 1 0 -UBA52-RPS27A-UBB-UBC ubiquitin Ubiquitin-like modifier P62991 mouse K11-ac 459088 FVKTLTGkTITLEVE ubiquitin protein degradation 33976225 3 3 0 forms an electrostatic interaction with D129, loss of K133 ubiquitylation or the K133:D129 salt bridge stabilizes IL-1B -EGR1 EGR1 C2H2-type zinc finger protein; DNA-binding; Transcription factor P18146 1958 5q31.2 human S104-p 11423700 YEHLTAEsFPDISLN transcription, altered DNA(DISRUPTS) 8662759 1 0 0 -WRN WRN Cell cycle regulation; DNA repair, damage; DNA-binding; EC 3.6.4.12; Helicase; Nucleolus Q14191 7486 8p12 human K887-ac 14512103 LTEIRNEkFRLYKLK RecQ_Zn_bind protein stabilization; ubiquitination 20428248 1 1 0 inhibits ubiquitination -RELA NFkB-p65 DNA-binding; Nuclear receptor co-regulator; Transcription factor Q04206 5970 11q13.1 human S45-p 25302163 CEGRSAGsIPGERST RHD_DNA_bind molecular association, regulation transcription, inhibited DNA(DISRUPTS) 27466442 1 6 2 -PTEN PTEN Carbohydrate Metabolism - inositol phosphate; EC 3.1.3.16; EC 3.1.3.48; EC 3.1.3.67; Motility/polarity/chemotaxis; Nuclear receptor co-regulator; PHOSPHATASE; Phosphatase, lipid; Tumor suppressor P60484 5728 10q23.31 human K327-ub 1881390900 LTKNDLDkANKDKAN protein degradation; phosphorylation 34785642 1 0 0 AKT S473 increased ; regulates the HCC cell chemoresistance (chemoresistant) -RPS6KB1 p70S6K iso2 EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, AGC; Protein kinase, Ser/Thr (non-receptor); Translation P23443-2 6198 17q23.1 human S371-p 448806 TRQTPVDsPDDSTLS Pkinase_C carcinogenesis, induced; cell motility, induced; cell growth, induced; apoptosis, inhibited; signaling pathway regulation 31974627 17 4 11 PI3K/Akt/mTOR signaling pathway -CHEK1 Chk1 EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, CAMK; Protein kinase, Ser/Thr (non-receptor); Tumor suppressor O14757 1111 11q24.2 human S296-p 447832 GFSKHIQsNLDFSPV activity, induced; molecular association, regulation; intracellular localization; enzymatic activity, induced cell cycle regulation; carcinogenesis, induced; transcription, induced; signaling pathway regulation; cell growth, induced; apoptosis, inhibited; transcription, inhibited; cell growth, altered 14-3-3 gamma(INDUCES); claspin(INDUCES); CDC25A(INDUCES) 15707391; 17976513; 20639859; 24240236; 26140595; 30573684; 31209037; 31597105; 32076484; 33414171; 33591599; 34508175; 34773074; 37023702 31 16 10 -ATF4 ATF-4 DNA-binding; Transcription factor P18848 468 22q13.1 human S224-p 1734100 NDSGICMsPESYLGS molecular association, regulation FBW1B(INDUCES) 18052253 1 0 0 -Tnnt2 TNNT2 Motility/polarity/chemotaxis; Motor P50752 21956 1 E4|1 59.32 cM mouse S288-p 457603 INDNQKVsKTRGKAK Troponin phosphorylation cytoskeletal reorganization 15774859 3 0 0 ROCK II induced desensitization to Ca++ and depression in maximal tension. -Pin1 PIN1 EC 5.2.1.8; Isomerase; Nuclear receptor co-regulator Q9QUR7 23988 9 A3|9 7.6 cM mouse S16-p 447772 PGWEKRMsRSSGRVY WW enzymatic activity, inhibited translation, altered 20215645 12 2 0 -CSRP1 CSRP1 Cytoskeletal; Motility/polarity/chemotaxis P21291 1465 1q32.1 human Y62-p 2091905 EIYCKSCyGKKYGPK LIM intracellular localization 12802285 1 0 0 -MUC1 MUC1 Actin-binding; Cell adhesion; Membrane protein, integral; Motility/polarity/chemotaxis; Nuclear receptor co-regulator; Tumor suppressor P15941 4582 1q22 human Y1229-p 448462 SSTDRSPyEKVSAGN molecular association, regulation GSK3B(DISRUPTS); CTNNB1(INDUCES) 11152665 5 10 447 -ULK2 ULK2 Autophagy; EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, Other; Protein kinase, Ser/Thr (non-receptor) Q8IYT8 9706 17p11.2 human S1027-p 41294001 CSIERRLsALCHSTA DUF3543 molecular association, regulation; intracellular localization autophagy, inhibited ATG101(DISRUPTS); RB1CC1(DISRUPTS) 26052940 1 0 0 nuclear localization -Rack1 RACK1 Adaptor/scaffold; G protein; G protein, heterotrimeric; G protein, heterotrimeric beta; Motility/polarity/chemotaxis; Nuclear receptor co-regulator P68040 14694 11|11 B1.2 mouse S110-p 31879014 GHTKDVLsVAFSSDN WD40 protein degradation; molecular association, regulation; ubiquitination UBE2T(INDUCES) 35265209 1 1 0 -RNF4 RNF4 EC 6.3.2.-; Ligase; Nuclear receptor co-regulator; Transcription factor; UBIQUITIN LIGASE; Ubiquitin conjugating system; Ubiquitin ligase P78317 6047 4p16.3 human T26-p 41192600 RTREATStPEISLEA enzymatic activity, induced 25948581 1 0 0 regulates homologous recombination repair during S-phase -Sox9 SOX9 DNA-binding; Transcription factor Q04887 20682 11 E2|11 77.27 cM mouse R178-me 10338211 DYKYQPRrRKSVKNG molecular association, regulation cell cycle regulation; cell growth, induced; transcription, induced CTNNB1(DISRUPTS) 19725955 1 0 0 promotes cyclin D1 expression, regulates endochondral ossification, chondrocyte/cartilage development during embryogenesis -PLD1 PLD1 EC 3.1.4.4; Lipid Metabolism - ether lipid; Lipid Metabolism - glycerophospholipid; Motility/polarity/chemotaxis; Phospholipase Q13393 5337 3q26.31 human S505-p 11091057 GSVKRVTsGPSLGSL enzymatic activity, induced 20231899 1 2 1 in response to glucose deprivation -CEACAM3 CEACAM3 Cell adhesion; Immunoglobulin superfamily; Membrane protein, integral P40198 1084 19q13.2 human Y230-p 478344 PRTAASIyEELLKHD molecular association, regulation endocytosis, induced PIK3C2A(INDUCES); VAV1(INDUCES) 17339478; 21216968; 35850306 3 0 1 important for bacterial uptake (N. gonorrhoeae) and killing of internalized pathogens; induces phagocytosis; Vav1 required for CEACAM3-mediated phagocytosis of bacterial pathogens; specific interaction between SH2 domain of VAV1 and ITAM-like sequence of CEACAM3 -Pak2 PAK2 EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, STE; Protein kinase, Ser/Thr (non-receptor) Q8CIN4 224105 16 B2|16 22.4 cM mouse S141-p 448295 TVKQKYLsFTPPEKD cell growth, induced 33539470 17 84 76 induces neurite outgrowth -ECPAS ECM29 Vesicle Q5VYK3 23392 9q31.3 human S1666-p 25296914 IPLIKKNsLESSGVR molecular association, regulation DYNC1I1(INDUCES) 26609957 1 1 1 increased retrograde transport of proteasomes in growing axons -Dlg4 PSD-95 Adaptor/scaffold P31016 29495 10q24 rat S295-p 456936 PTSPRRYsPVAKDLL PDZ_assoc activity, induced; protein stabilization; intracellular localization 17988632; 23864697 4 12 0 Dephosphorylation of S295 induce phosphorylation at site T19; enhances GluR surface expression and current potentiation -XRCC5 Ku80 DNA-binding; EC 3.6.1.-; EC 3.6.4.-; Helicase; Nuclear receptor co-regulator; Nucleolus; RNA-binding P13010 7520 2q35 human K36-ub 12407332 SPFEQAKkVITMFVQ Ku_N molecular association, regulation DNA repair, induced DNA(DISRUPTS) 27895153 1 2 1 -Nfatc2 NFAT1 DNA-binding; Transcription factor Q60591 18019 2 H3|2 88.91 cM mouse S276-p 447850 ASPQRSRsPSPQPSP transcription, inhibited 11030334 0 1 0 -FOXM1 FOXM1 DNA-binding; Transcription factor Q08050 2305 12p13.33 human S672-p 467914 QSAPPLEsPQRLLSS protein stabilization transcription, induced 22094256 1 3 0 -SHC1 SHC1 Adaptor/scaffold; Apoptosis; Mitochondrial; Motility/polarity/chemotaxis P29353 6464 1q21.3 human S213-p 58109401 TRRRKPCsRPLSSIL PID apoptosis, induced 27624939 1 1 0 -NR3C2 MCR DNA-binding; Nuclear receptor P08235 4306 4q31.23 human K399-sm 3144810 LNIVQYIkPEPDGAF transcription, induced; transcription, inhibited 14500761; 17105732 3 1 0 Ubc9 can be a transcriptional mineralocorticoid receptor coactivator. -HSPB1 HSP27 Chaperone; Heat shock protein; Motility/polarity/chemotaxis; SUMO LIGASE; SUMO ligase P04792 3315 7q11.23 human S78-p 448402 PAYSRALsRQLSSGV protein degradation; molecular association, regulation; phosphorylation; activity, induced; sumoylation; ubiquitination; intracellular localization; protein conformation cell cycle regulation; carcinogenesis, induced; apoptosis, altered; cell motility, induced; signaling pathway regulation; transcription, altered; autophagy, induced; cell differentiation, induced; cell growth, induced; apoptosis, inhibited; cytoskeletal reorganization; transcription, inhibited; cell growth, altered TRAF6(DISRUPTS); TPM1(INDUCES); p53(INDUCES); HSF1(DISRUPTS); hnRNP D0(DISRUPTS); HSP27(DISRUPTS) RNA(DISRUPTS) 11383510; 11912188; 12367505; 14749215; 15581903; 18477563; 18720982; 18950704; 19597476; 21245386; 34477462; 34498800; 34516752; 34851698; 35000271; 35499078; 36701233 40 25 30 induces lysophagy -Akt1 Akt1 EC 2.7.11.1; KINASE; Kinase, protein; Oncoprotein; Protein kinase, AGC; Protein kinase, Ser/Thr (non-receptor) P31750 11651 12 F1|12 61.2 cM mouse Y326-p 447858 EVLEDNDyGRAVDWW Pkinase enzymatic activity, induced apoptosis, altered 11445557; 20606012 3 2 26 -SQLE SQLE EC 1.14.13.132; Endoplasmic reticulum; Lipid Metabolism - steroid biosynthesis; Membrane protein, integral; Membrane protein, multi-pass; Oxidoreductase Q14534 6713 8q24.13 human S83-p 1877421600 IGFFWAKsPPESENK protein degradation; molecular association, regulation; ubiquitination carcinogenesis, inhibited; cell growth, inhibited; apoptosis, induced MARCH6(INDUCES) 35767703 1 0 0 -Tnp2 TP2 DNA-binding P11101 24840 10q11 rat K88-ac 10769110 NRKTLEGkVSKRKAV TP2 molecular association, regulation chromatin organization, altered NPM3(DISRUPTS) 19710011 2 3 0 -Cttn Cortactin Actin-binding; Cytoskeletal; Motility/polarity/chemotaxis NP_001385572 60465 1q41-q42 rat S135-p 31881968 QMDRVDQsAVGFEYQ HS1_rep molecular association, regulation cytoskeletal reorganization ACTB(DISRUPTS) 26033110 1 2 0 phospho-mimetic mutant shows atypical growth cone filopodia -Ano1 ANO1 Membrane protein, integral; Membrane protein, multi-pass; Transporter; Transporter, ion channel Q8BHY3 101772 7|7 F5 mouse S471-p 50773175 EKSLRKEsRNKETDK Anoctamin activity, induced 31461344 2 1 0 -Gata4 GATA4 Motility/polarity/chemotaxis; Transcription factor Q08369 14463 14 D1|14 33.24 cM mouse S160-p 31834900 GFAGSYSsPYPAYMA GATA-N transcription, induced CCND2(INDUCES) 24474767 1 0 0 -Stx7 STX7 Membrane protein, integral; Vesicle O70439 53331 10|10 A4 mouse S125-p 468880 FVARVRAsSRVSGGF molecular association, regulation STX8(INDUCES); VTI1B(INDUCES); VAMP8(INDUCES) 18710945 1 8 58 -LCP2 SLP76 Adaptor/scaffold Q13094 3937 5q35.1 human K30-ub 25786202 YFKKLNYkDCEKAVK SAM_2 ubiquitination 22902619 1 1 0 -Rims1 RIMS1 Adaptor/scaffold; Vesicle Q9JIR4 84556 9q13 rat S1045-p 4725312 PRAKRGRsAESLHMT neural plasticity 35443170 1 6 0 -TRAF3 TRAF3 UBIQUITIN LIGASE; Ubiquitin conjugating system; Ubiquitin ligase Q13114 7187 14q32.32 human T29-p 23154950 HTDRSAGtPVFVPEQ cell growth, induced; apoptosis, inhibited; transcription, induced; signaling pathway regulation 34255829 1 2 2 induces NIK stabilization and NF-kB signaling -PFKP PFKP Carbohydrate Metabolism - fructose and mannose; Carbohydrate Metabolism - galactose; Carbohydrate Metabolism - glycolysis and gluconeogenesis; Carbohydrate Metabolism - pentose phosphate pathway; EC 2.7.1.11; KINASE; Kinase, other Q01813 5214 10p15.2 human S386-p 483639 AVRLRGRsFAGNLNT molecular association, regulation; protein stabilization; ubiquitination; enzymatic activity, induced; phosphorylation carcinogenesis, induced; autophagy, induced; cell motility, induced; cell growth, induced; transcription, induced SYVN1(DISRUPTS); ATG4B(INDUCES) 33588886; 33607258; 36435833 3 44 190 -SKAP2 SKAP2 Adaptor/scaffold O75563 8935 7p15.2 human Y261-p 449668 QPIDDEIyEELPEEE cell motility, induced 26577701 5 8 100 macrophages migration towards cancer cells -DMD dystrophin Cytoskeletal; Motility/polarity/chemotaxis P11532 1756 Xp21.2-p21.1 human T3361-p 35542206 YPMVEYCtPTTSGED protein stabilization; molecular association, regulation cytoskeletal reorganization DAG1(INDUCES) 25082828 1 2 0 -ESPL1 separase EC 3.4.22.49; Protease Q14674 9700 12q13.13 human S1399-p 1211206 KVNFSDDsDLEDPVS enzymatic activity, inhibited CDK1(INDUCES) 17974570 1 13 0 phosphorylation of S1399 is a key residue in CDK1-dependent inhibition of separase -Nfe2l1 NFE2L1 DNA-binding; Transcription factor Q61985 18023 11 D|11 60.12 cM mouse S497-p 28700306 EGAVGYSsDSETLDL transcription, inhibited 23816881 1 0 0 -MVP MVP RNA-binding Q14764 9961 16p11.2 human S864-p 480371 PLGRRVAsGPSPGEG molecular association, regulation; activity, inhibited DNA repair, induced 14-3-3 epsilon(INDUCES) 23590642 1 2 67 14-3-3e negatively regulating the BLM resistance activity of MVP and induce DDR -EPAS1 HIF2A DNA-binding; Transcription factor Q99814 2034 2p21 human T406-p 1874020204 ELAQLAPtPGDAIIS protein stabilization 34285132 1 0 0 -Slc12a1 NKCC2 Membrane protein, integral; Membrane protein, multi-pass; Transporter; Transporter, SLC family P55014 20495 2 F1|2 61.23 cM mouse T96-p 458227 TNTYYLQtFGHNTMD AA_permease_N activity, induced 12732642; 24808538 15 2 0 -Mef2d MEF2D DNA-binding; Transcription factor Q63943 17261 3 F1|3 38.78 cM mouse S437-p 449407 SIKSEPVsPSRERSP apoptosis, induced 16407541 7 19 26 -N Nucleocapsid Protein P59595 1489678 SARSCoV1 K62-sm 1868657900 TALTQHGkEELRFPR CoV_nucleocap molecular association, regulation Nucleocapsid Protein(INDUCES) 15848177 1 0 0 sumoylation-mediated homo-oligomerization -CFL1 Cofilin-1 Cytoskeletal; Motility/polarity/chemotaxis; Nuclear receptor co-regulator P23528 1072 11q13.1 human S24-p 9218418 DMKVRKSsTPEEVKK Cofilin_ADF molecular association, regulation cytoskeletal reorganization 14-3-3 zeta(INDUCES) 22855535 1 8 9 inhibition of depolymerization of actin, cessation of degranulation -Nampt PBEF Cell cycle regulation; Cofactor and Vitamin Metabolism - nicotinate and nicotinamide; Cytokine; EC 2.4.2.12; Transferase Q99KQ4 59027 12|12 A3 mouse K53-ac 33351372 NSKVRKVkYEETVFY NAMPT_N enzymatic activity, inhibited 25921090 1 2 1 inhibits PBEF secretion -TERF2 TRF2 DNA repair, damage; DNA-binding Q15554 7014 16q22.1 human S365-p 452842 PTQALPAsPALKNKR molecular association, regulation; protein stabilization cell cycle regulation; cell growth, induced RTEL1(DISRUPTS) 27366950; 31723267 3 66 94 -Kcnb1 Kv2.1 Channel, cation; Channel, ligand-gated; Channel, potassium; Membrane protein, integral; Membrane protein, multi-pass Q03717 16500 2 H3|2 87.22 cM mouse S457-p 473558 MKDAFARsIEMMDIV activity, induced 24962901 4 6 0 -TFAP2A AP-2 alpha DNA-binding; Transcription factor P05549 7020 6p24.3 human K10-sm 580826098 WKLTDNIkYEDCEDR activity, induced transcription, induced 30926672 1 2 0 enhances transcription of HIF1A -CDC25A CDC25A EC 3.1.3.48; Motility/polarity/chemotaxis; PHOSPHATASE; Protein phosphatase, dual-specificity P30304 993 3p21.31 human S88-p 458298 DSGFCLDsPGPLDSK M-inducer_phosp protein degradation; molecular association, regulation; ubiquitination; phosphorylation cell cycle regulation; apoptosis, inhibited BTRC(INDUCES); FBW1B(INDUCES) 14603323; 15798217; 19734889; 28192398; 34156324; 34363019 7 2 0 -Vcl Vinculin Cell adhesion; Cytoskeletal; Motility/polarity/chemotaxis Q64727 22330 14 A3|14 11.53 cM mouse Y1065-p 454003 WVRKTPWyQ______ Vinculin activity, induced; molecular association, regulation; protein conformation cell adhesion, induced; cell motility, altered; cytoskeletal reorganization 20006947; 26240176 9 1 22 increases interaction with F-actin and talin -PAX6 PAX6 iso2 DNA-binding; Motility/polarity/chemotaxis; Transcription factor P26367-2 5080 11p13 human K89-sm 1877427000 PRAIGGSkPRVATPE PAX protein degradation 32826860 1 0 0 SENP1-mediated de-SUMOylation improves the stability of PAX6 and has protective effects of PAX6 on corneal endothelial injuries -ESR1 ER-alpha DNA-binding; Nuclear receptor; Transcription factor P03372 2099 6q25.1-q25.2 human K302-m1 3084639 PLMIKRSkKNSLALS protein stabilization transcription, induced 18471979 1 1 0 -BACE1 BACE EC 3.4.23.46; Membrane protein, integral; Protease P56817 23621 11q23.3 human K275-ac 478257 EINGQDLkMDCKEYN Asp protein stabilization; intracellular localization 17425515 1 1 0 regulates translocation through secretory pathway -PIN1 PIN1 EC 5.2.1.8; Isomerase; Nuclear receptor co-regulator Q13526 5300 19p13.2 human Y23-p 473849 SRSSGRVyYFNHITN WW molecular association, regulation cell cycle regulation KIF20B(INDUCES) 10037602; 11470801 2 1 3 regulates association to phosphopeptides; in vitro and in vivo -E2F1 E2F1 DNA-binding; Transcription factor Q01094 1869 20q11.22 human K161-ub 95155308 NWAAEVLkVQKRRIY E2F_TDP protein stabilization DNA repair, induced; cell growth, induced; transcription, induced DNA(INDUCES) 28542143 1 0 0 -EPS8 EPS8 Adaptor/scaffold Q12929 2059 12p12.3 human Y525-p 457963 NRHIDRNyEPLKTQP cell cycle regulation; cell motility, induced 32641864 3 20 399 -RACK1 RACK1 Adaptor/scaffold; G protein; G protein, heterotrimeric; G protein, heterotrimeric beta; Motility/polarity/chemotaxis; Nuclear receptor co-regulator P63244 10399 5q35.3 human Y52-p 464119 LTRDETNyGIPQRAL molecular association, regulation; protein conformation; phosphorylation cell motility, altered; cell adhesion, altered; signaling pathway regulation; cell growth, altered CaR(DISRUPTS); FAK(INDUCES) 19423701; 23652203 2 1 230 EGFR signaling for CAR activation -PVR PVR Immunoglobulin superfamily; Membrane protein, integral; Motility/polarity/chemotaxis; Receptor, misc. P15151 5817 19q13.31 human Y398-p 450742 SANGHVSySAVSREN molecular association, regulation 15194502 1 4 17 -PDCD5 PDCD5 Apoptosis O14737 9141 19q13.11 human K97-ub 12246096 QGLIEILkKVSQQTE dsDNA_bind protein degradation apoptosis, inhibited 25499082 1 3 9 -Gabbr2 GABBR2 GPCR, family 3; Membrane protein, integral; Membrane protein, multi-pass; Receptor, GPCR Q80T41 242425 4|4 B1 mouse S783-p 473060 VTSVNQAsTSRLEGL GBR2_CC protein degradation; receptor recycling, induced; intracellular localization; receptor internalization, inhibited signaling pathway regulation; endocytosis, inhibited 24094109; 32083308; 32111696; 33432190; 36311027 10 0 0 -GATA1 GATA1 DNA-binding; Transcription factor P15976 2623 Xp11.23 human S161-p 40407600 SSLPVPNsAYGGPDF molecular association, regulation carcinogenesis, induced; cell motility, induced HDAC3(INDUCES); HDAC4(INDUCES) 25726523 1 0 0 GATA1-HDAC3/4 complex induces EMT of breast cancer cells, inhibits E-cadherin and promotes fibronectin expression -CDC25A CDC25A EC 3.1.3.48; Motility/polarity/chemotaxis; PHOSPHATASE; Protein phosphatase, dual-specificity P30304 993 3p21.31 human K150-ac 56843600 NEAFEFKkPVRPVSR M-inducer_phosp protein stabilization cell cycle regulation 27462461 1 0 0 -BIRC5 Survivin Apoptosis O15392 332 17q25.3 human S20-p 485776 FLKDHRIsTFKNWPF BIR protein stabilization; molecular association, regulation; intracellular localization; phosphorylation cell cycle regulation; apoptosis, induced XIAP(DISRUPTS) 17612487; 20427271; 21148584; 24069188; 27332895 6 1 0 chromos ome alignment, segregation, and possibly cytokinesis; stimulates Aurora B activation and increases phosphorylation of CENPA S7; critical for accurate chromosome segregation -Cnbp ZNF9 DNA-binding; RNA-binding; Transcription factor P53996 12785 6|6 D1 mouse T177-p 25320968 RECTIEAtA______ molecular association, regulation; intracellular localization transcription, induced DNA(INDUCES) 34168080 1 2 1 regulates Type I IFN promoter activity -ATR ATR EC 2.7.11.1; KINASE; Kinase, protein; Membrane protein, integral; Protein kinase, Ser/Thr (non-receptor); Protein kinase, atypical Q13535 545 3q23 human T1589-p 22561303 FSMLDHLtQWARHKF cell cycle regulation; cell growth, induced 21908846 1 1 0 -GRB10 GRB10 Adaptor/scaffold Q13322 2887 7p12.1 human S150-p 454185 PELCGPGsPPVLTPG protein stabilization; activity, inhibited 15952796; 21659604 2 5 0 -JUP CTNNG Cytoskeletal; Motility/polarity/chemotaxis P14923 3728 17q21.2 human S665-p 2048381 PDYRKRVsVELTNSL cell adhesion, induced 32508670 2 35 0 causes ultrastructural alterations at ICD -KRT8 K8 Cytoskeletal P05787 3856 12q13.13 human K483-ac 474633 ESSDVLPk_______ cytoskeletal reorganization 18203277; 18983182 3 3 37 -Epb4.9 dematin iso2 Actin-binding; Motility/polarity/chemotaxis; Tumor suppressor Q9WV69-2 13829 14 D2|14 36.32 cM mouse S381-p 450255 NELKKKAsLF_____ VHP molecular association, regulation; protein conformation 27073223 5 0 0 headpiece domain of dematin-S381E strongly interacts with the core domain -IL2RB IL2RB Membrane protein, integral; Receptor, cytokine P14784 3560 22q12.3 human Y536-p 450934 LPLNTDAyLSLQELQ molecular association, regulation apoptosis, inhibited; cell growth, altered STAT5A(INDUCES); STAT5B(INDUCES); SHB(INDUCES) 10602027; 12200137 3 3 2 -Rps6ka1 p90RSK EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, AGC; Protein kinase, Ser/Thr (non-receptor); Translation P18653 20111 4|4 D2.3 mouse S369-p 447990 HQLFRGFsFVATGLM Pkinase_C enzymatic activity, induced 16103085 66 48 64 -Mecp2 MECP2 Transcription, coactivator/corepressor Q9Z2D6 17257 X A7.3|X 37.63 cM mouse T158-p 31879716 DPNDFDFtVTGRGSP MBD sumoylation; phosphorylation transcription, induced 31974426 2 0 0 decrease GSK3 beta phosphoryation; inhibition of locomotor activity; Bdnf mRNA expression level increased -Mef2d MEF2D DNA-binding; Transcription factor Q63943 17261 3 F1|3 38.78 cM mouse S180-p 449933 LTDPRLLsPQQPALQ activity, induced 10849446 3 44 11 -FANCD2 FANCD2 DNA repair, damage Q9BXW9 2177 3p25.3 human S331-p 11315004 KSKGRASsSGNQESS FancD2 molecular association, regulation; ubiquitination BRCA2(INDUCES) 19861535 1 1 0 confers resistance to mitomycin C -FSCN1 fascin Actin-binding; Cytoskeletal; Motility/polarity/chemotaxis Q16658 6624 7p22.1 human K41-ub 8101911 NASASSLkKKQIWTL Fascin cytoskeletal reorganization 27879315 1 2 5 fascin bundling activity -Pink1 PINK1 EC 2.7.11.1; KINASE; Kinase, protein; Membrane protein, integral; Mitochondrial; Protein kinase, Other; Protein kinase, Ser/Thr (non-receptor) Q99MQ3 68943 4|4 D3 mouse S411-p 1883601200 VERGGNGsLMAPEVS Pkinase phosphorylation 36469690 1 1 0 inhibits phosphorylation of UBA52 -Bad BAD Apoptosis Q61337 12015 19|19 A mouse T201-p 450485 NLGKGGStPSQ____ Bcl-2_BAD activity, induced; molecular association, regulation apoptosis, inhibited Bcl-xL(DISRUPTS) 14967141; 18469002 3 0 0 -Yap1 YAP1 Oncoprotein; Transcription, coactivator/corepressor P46938 22601 9|9 A1 mouse S112-p 448847 PQHVRAHsSPASLQL protein degradation; molecular association, regulation; intracellular localization; activity, inhibited cell differentiation, inhibited; apoptosis, altered; carcinogenesis, altered; carcinogenesis, inhibited; apoptosis, induced; cell motility, induced; cell growth, inhibited; cell adhesion, induced; cell motility, inhibited; signaling pathway regulation; transcription, altered; cell differentiation, altered; cell differentiation, induced; cell growth, induced; transcription, inhibited 14-3-3 beta(INDUCES); 14-3-3 epsilon(INDUCES); CTNNA1(INDUCES) 11118213; 19289085; 21376238; 23644383; 26109051; 26657153; 26757814; 33046882; 33686240; 34108620; 34133792; 34531315; 34608264; 34615998; 34874744; 35358489; 35394840; 35413847; 35619099; 35696363; 35697803; 35798842; 36374802; 36640330 207 33 180 -Xbp1 XBP1 iso2 DNA-binding; Transcription factor O35426-2 22433 mouse K297-ac 1879877103 PEFIVSVkKEPLEDD protein degradation apoptosis, induced 31541078 1 1 0 K257 and 297 mediates hepatic steatosis, apoptosis, and insulin resistance -Nefm NFM Cytoskeletal P08553 18040 14|14 D1 mouse S645-p 451040 KKEVTKEsPKEEKVE cytoskeletal reorganization 19193875 1 6 0 slightly altered axoplasmic organization in 7S/A mice mutant -SNW1 Skip Nuclear receptor co-regulator; Spliceosome; Transcription, coactivator/corepressor Q13573 22938 14q24.3 human Y292-p 464278 AKLAEALyIADRKAR SKIP_SNW molecular association, regulation transcription, induced SMAD3(INDUCES) 28666867 1 5 65 enhances TGF-beta-induced Smad3 transcriptional activitation -PSMA5 PSMA5 EC 3.4.25.1; Protease; Proteasome complex P28066 5686 1p13.3 human S16-p 483589 DRGVNTFsPEGRLFQ Proteasome_A_N molecular association, regulation; phosphorylation cell cycle regulation; cell growth, induced; signaling pathway regulation PKN2(INDUCES); RP1(INDUCES); AMPD2(INDUCES); CLCC1(INDUCES); PLK1(INDUCES) 34831298 1 44 2 inhibits CDK1 phosphorylation and regulates phospho-a5/PLK1/CDK1 signaling -Bcar1 P130Cas Adaptor/scaffold; Motility/polarity/chemotaxis Q61140 12927 8|8 E1 mouse Y414-p 448720 SVVDDGVyAVPPPAE carcinogenesis, induced; cell motility, induced; cell motility, altered; cytoskeletal reorganization 20430882; 36375119 18 23 126 -Lyn LYN EC 2.7.10.2; KINASE; Kinase, protein; Oncoprotein; Protein kinase, TK; Protein kinase, tyrosine (non-receptor) P25911 17096 4 A1|4 2.05 cM mouse Y508-p 447624 YTATEGQyQQQP___ molecular association, regulation; intracellular localization; enzymatic activity, inhibited endocytosis, induced; cell growth, inhibited; signaling pathway regulation Bcr(INDUCES) 10415030; 16920712; 21636860; 21964606; 35500650 27 48 1560 induces JNK signaling -Sstr3 SSTR3 GPCR, family 1; Membrane protein, integral; Membrane protein, multi-pass; Receptor, GPCR P30936 171044 7q34 rat S351-p 456710 VRSQEPGsGPPEKTE receptor desensitization, altered; receptor internalization, altered 9295322 1 1 0 -Cilk1 ICK EC 2.7.11.22; KINASE; Kinase, protein; Protein kinase, CMGC; Protein kinase, Ser/Thr (non-receptor) Q9JKV2 56542 9|9 E1 mouse T157-p 456051 IRSRPPYtDYVSTRW Pkinase enzymatic activity, induced 15988018 3 21 86 -MDC1 MDC1 Cell cycle regulation Q14676 9656 6p21.33 human S299-p 477757 SQPPGEDsDTDVDDD molecular association, regulation cell cycle regulation NBS1(INDUCES) 18678890 1 26 17 MDC1-NBS1 interaction regulates intra-S-phase checkpoint activation -Sp7 osterix C2H2-type zinc finger protein; DNA-binding; Transcription factor Q8VI67 170574 15|15 F3 mouse S77-p 15334101 GLLSPAGsPPAPASG activity, induced; protein degradation; molecular association, regulation; ubiquitination cell differentiation, inhibited; transcription, altered FBXW7(INDUCES); p300(INDUCES); SMARCA4(INDUCES) 20682789; 32931083 4 0 0 -LCP2 SLP76 Adaptor/scaffold Q13094 3937 5q35.1 human Y145-p 448220 PVEDDADyEPPPSND molecular association, regulation; phosphorylation exocytosis, induced; cytoskeletal reorganization; transcription, induced NCK1(INDUCES); VAV1(INDUCES) 11046020; 12817019; 17148460; 21725281; 22534133; 33931484 21 1 0 -PMAIP1 NOXA Apoptosis; Mitochondrial Q13794 5366 18q21.32 human S13-p 17790900 ARKNAQPsPARAPAE PMAIP1 molecular association, regulation apoptosis, altered; carcinogenesis, altered; apoptosis, inhibited; cell growth, altered MCL1(DISRUPTS) 21145489; 26411306 3 3 0 -GSK3B GSK3B EC 2.7.11.1; EC 2.7.11.26; KINASE; Kinase, protein; Protein kinase, CMGC; Protein kinase, Ser/Thr (non-receptor) P49841 2932 3q13.33 human S9-p 449111 SGRPRTTsFAESCKP protein degradation; protein stabilization; molecular association, regulation; enzymatic activity, inhibited; activity, inhibited; phosphorylation; ubiquitination; intracellular localization; enzymatic activity, altered cell cycle regulation; carcinogenesis, induced; apoptosis, altered; cell motility, induced; apoptosis, induced; signaling pathway regulation; cell growth, induced; cell motility, altered; transcription, inhibited; cell growth, altered; carcinogenesis, inhibited; cell growth, inhibited; transcription, induced; transcription, altered; autophagy, induced; cell differentiation, induced; apoptosis, inhibited; cytoskeletal reorganization; cell adhesion, altered CRMP-2(DISRUPTS) 11035810; 11389054; 11520785; 11579131; 11877389; 11956225; 12167628; 12522140; 12900420; 12917346; 15033922; 15878878; 15950778; 16039586; 16115820; 16155008; 16397900; 16484495; 18451303; 18757413; 18794113; 19179806; 20352103; 20637111; 21308747; 21422248; 21530327; 21868755; 21893193; 21996745; 22385658; 24879152; 30154149; 32382110; 33184107; 33388549; 33661942; 33829789; 33890983; 33967735; 34101073; 34237099; 34287648; 34326276; 34433641; 34484860; 34639123; 34966427; 34975828; 35090098; 35090553; 35347072; 35347116; 35564180; 35565964; 35698879; 35739087; 35853487; 35884549; 35986274; 36520954; 36575468; 36635496; 36648507; 36869126; 37400529; 37495110; 37500620; 7980435 570 46 227 -PDCD1 PD-1 Apoptosis; Membrane protein, integral Q15116 5133 2q37.3 human K233-ub 1877141202 LDFQWREkTPEPPVP protein degradation 33109719 3 0 0 -BHLHE40 BHLHB2 Nucleolus; Transcription regulation O14503 8553 3p26.1 human K159-sm 31089509 EVLQYLAkHENTRDL Hairy_orange protein stabilization; intracellular localization transcription, inhibited 21829689; 27626674 2 1 0 -KAT7 MYST2 ACETYLTRANSFERASE; Acetyltransferase; EC 2.3.1.48; Nuclear receptor co-regulator; Transcription, coactivator/corepressor O95251 11143 17q21.33 human S50-p 460900 TRSSARLsQSSQDSS protein degradation; molecular association, regulation; ubiquitination cell cycle regulation; cell growth, inhibited DDB2(INDUCES) 26572825 1 23 84 -MEF2C MEF2C DNA-binding; Transcription factor Q06413 4208 5q14.3 human K116-ac 12674411 HSPESEDkYRKINED HJURP_C molecular association, regulation cell differentiation, induced; transcription, induced MRF(INDUCES) DNA(INDUCES) 15831463 1 0 0 -Irf6 IRF6 DNA-binding; Transcription factor P97431 54139 1 H6|1 97.6 cM mouse S424-p 27451041 GSVRLQIsTPDIKDN activity, induced; phosphorylation cell differentiation, induced; transcription, induced 31578523 3 9 0 -NUSAP1 NUSAP1 Cell cycle regulation; Nucleolus Q9BXS6 51203 15q15.1 human T300-p 7989914 HKRSLTKtPARKSAH NUSAP molecular association, regulation; intracellular localization cytoskeletal reorganization 22101338 1 1 3 inhibits NUSAP binding to microtubules in mitosis -CDC73 CDC73 Cell cycle regulation; Tumor suppressor Q6P1J9 79577 1q31.2 human K247-ub 12302328 STGKNFSkNIFAILQ CDC73_N protein degradation; ubiquitination 35551175 1 5 28 -Arrdc3 ARRDC3 Unknown function Q7TPQ9 105171 13|13 C2 mouse Y382-p 462206 LQGPLFAyIQEFRFL molecular association, regulation INSR(INDUCES) 32156724 1 3 9 -POLH POLH DNA repair, damage; EC 2.7.7.7; Transferase Q9Y253 5429 6p21.1 human K474-sm 1877365913 GPAVTATkKATTSLE intracellular localization; enzymatic activity, inhibited 32350109 1 1 0 -ATXN3 ataxin-3 iso1 DEUBIQUITINASE; DNA repair, damage; EC 3.4.19.12; Protease; Transcription regulation; Ubiquitin-specific protease P54252-1 4287 14q32.12 human S236-p 9441003 LQRALALsRQEIDME UIM activity, induced; intracellular localization transcription, altered 19542537 1 2 0 -Rps6kb1 p70S6K EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, AGC; Protein kinase, Ser/Thr (non-receptor); Translation P67999 83840 10q26 rat S434-p 448356 SFEPKIRsPRRFIGS phosphorylation; enzymatic activity, induced cytoskeletal reorganization 17220300; 25903132 28 1 0 dendritic spine morphogenesis; required for p70S6K T412 phosphorylation which leads to enzymatic activation -Crebbp CBP ACETYLTRANSFERASE; Acetyltransferase; DNA-binding; EC 2.3.1.48; Motility/polarity/chemotaxis; Nuclear receptor co-regulator; Transcription, coactivator/corepressor P45481 12914 16 A1|16 2.4 cM mouse K1057-sm 3726904 EEKKPEVkVEAKEEE molecular association, regulation transcription, inhibited DAXX(INDUCES); HDAC2(INDUCES) 16287980 1 1 0 -BLM BLM DNA repair, damage; DNA replication; EC 3.6.4.12; Helicase P54132 641 15q26.1 human K344-sm 2293705 TSKDLLSkPEKMSMQ BLM_N intracellular localization 31171703 2 1 0 localization to PML bodies determined by the ratio of SUMO and SIM in telomere clustering scaffolds -Ffar4 GPR120 GPCR, family 1; Lipid-binding; Membrane protein, integral; Membrane protein, multi-pass; Receptor, GPCR Q7TMA4 107221 19|19 C2 mouse S361-p 54179700 NDLSVISs_______ receptor internalization, induced; molecular association, regulation ARR3(INDUCES) 26873857 1 0 0 -Prkd1 PRKD1 Autophagy; EC 2.7.11.13; KINASE; Kinase, protein; Motility/polarity/chemotaxis; Protein kinase, CAMK; Protein kinase, Ser/Thr (non-receptor) Q62101 18760 12|12 B3 mouse S916-p 447632 KALSERVsIL_____ molecular association, regulation; protein conformation; enzymatic activity, induced cell motility, altered; cytoskeletal reorganization ITGB1(INDUCES) 10473617; 10867018; 17485491; 24643961 43 13 0 -CLDN11 Claudin-11 Cell adhesion; Membrane protein, integral; Membrane protein, multi-pass O75508 5010 3q26.2 human Y191-p 478785 AFGENRFyYTAGSSS molecular association, regulation cell motility, altered Src(INDUCES) 30664792 1 3 76 -TEX14 TEX14 Cancer Testis Antigen (CTA); KINASE; Kinase, protein; Protein kinase, Other; Protein kinase, Ser/Thr (non-receptor) Q8IWB6 56155 17q22 human T618-p 25158902 EEASSPStGQPSLCS molecular association, regulation; intracellular localization PLK1(INDUCES) 22405274 1 0 0 -PAK1 PAK1 EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, STE; Protein kinase, Ser/Thr (non-receptor) Q13153 5058 11q13.5-q14.1 human K11-ub 56714903 NGLDIQDkPPAPPMR protein degradation 27302166 1 0 0 -VGLL4 VGLL4 iso4 Transcription, coactivator/corepressor Q14135-4 9686 3p25.3-p25.2 human S155-p 3195941 ASRPAGLsPTLTPGE VGLL4 cell cycle regulation; cell growth, induced 28739871 1 21 3 Mitotic phosphorylation -KIF14 KIF14 Microtubule-binding; Motor Q15058 9928 1q32.1 human S1217-p 114810405 PIKNLHSsHSSGLMD intracellular localization 28630147 1 0 0 spindle localization of Kif14 in anaphase -Ikzf1 Ikaros C2H2-type zinc finger protein; DNA-binding; Transcription factor Q03267 22778 11 A1|11 7.02 cM mouse S195-p 451356 TGHLRTHsVGKPHKC intracellular localization 12464629 1 1 0 -Irs1 IRS1 Adaptor/scaffold; Motility/polarity/chemotaxis P35569 16367 1 C5|1 42.0 cM mouse S1097-p 453434 GCRRRHSsETFSAPT activity, inhibited 15364919 13 39 122 -Camk4 CAMK4 EC 2.7.11.17; KINASE; Kinase, protein; Protein kinase, CAMK; Protein kinase, Ser/Thr (non-receptor) P08414 12326 18 B1|18 18.15 cM mouse T196-p 448164 EHQVLMKtVCGTPGY Pkinase transcription, induced; signaling pathway regulation 20952540 11 7 8 CAMK/CREB signaling pathway regulates transcription, activity of sympathetic neurons, and bone mass accrual. -L1CAM NCAM-L1 Cell adhesion; Membrane protein, integral Q90933 396059 chicken Y1186-p 456529 KDETFGEyRSLESEA Bravo_FIGEY intracellular localization 16087710 12 3 10 Alanine mutation directs protein to apical part of MDCK cells; phosphorylation functions in the sort of protein to basolateral surface. -CMKLR1 CMKLR1 GPCR, family 1; Membrane protein, integral; Membrane protein, multi-pass; Receptor, GPCR Q99788 1240 12q23.3 human Y316-p 32668901 SCMNPILyVFMGQDF 7tm_1; TM receptor internalization, induced 24658352 1 0 0 -RPS6KA4 MSK2 EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, AGC; Protein kinase, Ser/Thr (non-receptor) O75676 8986 11q13.1 human S347-p 447952 PVYSPPGsPPPGDPR Pkinase_C enzymatic activity, induced 10806207 1 39 4 -PAK3 PAK3 EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, STE; Protein kinase, Ser/Thr (non-receptor) O75914 5063 Xq23 human S154-p 448123 VNNQKYMsFTSGDKS carcinogenesis, induced; cell adhesion, induced; apoptosis, inhibited; cytoskeletal reorganization; signaling pathway regulation 17077177; 36319849 5 5 0 Mutation of any of the 4 serines/threonines to alanine reduced the AILIM/ICOS-induced elongation ratio in activated T cells. Three sites are believed to be autophosphorylation sites, and one is believed to be an Akt1 site. Treatment with Akt inhibitor shows a reduction in this elongation ratio.; induces the MAPK pathway -PDGFRB PDGFRB EC 2.7.10.1; KINASE; Kinase, protein; Membrane protein, integral; Oncoprotein; Protein kinase, TK; Protein kinase, tyrosine (receptor) P09619 5159 5q32 human Y579-p 447521 VSSDGHEyIYVDPMQ molecular association, regulation; phosphorylation; enzymatic activity, induced cell growth, altered RASA1(INDUCES); PLCG1(INDUCES); SHC1(INDUCES); PIK3R1(INDUCES) 10642538; 10683371; 8195171; 9454734; 9642269 11 1 0 -Bcl2l11 BIM Apoptosis O88498 64547 3q36 rat S65-p 449330 GPLAPPAsPGPFATR activity, induced; protein degradation; molecular association, regulation apoptosis, induced PIN1(INDUCES) 14681225; 15470142; 15728578; 16504941; 16818494 23 1 1 -Sirt7 SIRT7 DEACETYLASE; Deacetylase; EC 3.5.1.-; Nucleolus Q8BKJ9 209011 11|11 E2 mouse T264-p 1874512900 EAASKADtILCLGSS SIR2 protein stabilization; molecular association, regulation; ubiquitination; phosphorylation carcinogenesis, inhibited; cell motility, inhibited; transcription, inhibited; signaling pathway regulation UBR5(DISRUPTS); SKP2(INDUCES) 34433808 1 0 0 inhibits ubiquitination of itself, inhibits AKT phosphorylation and PI3K/AKT pathway; primes phosphorylation at T256 and S260 -YAP1 YAP1 Oncoprotein; Transcription, coactivator/corepressor P46937 10413 11q22.1 human K342-me 1880718704 PSTANSPkCQELALR activity, induced; intracellular localization transcription, induced 34795238 2 1 0 c-Met transcription -CYLD CYLD DEUBIQUITINASE; EC 3.4.19.12; Protease; Tumor suppressor; Ubiquitin conjugating system; Ubiquitin-specific protease Q9NQC7 1540 16q12.1 human K530-ub 573787426 YFTCALKkALFVKLK CAP_GLY protein degradation signaling pathway regulation 31366726 1 2 0 enhances NF-kB signaling. -Foxo4 FOXO4 DNA-binding; Oncoprotein; Transcription factor Q9WVH3 54601 X D|X 43.89 cM mouse K408-ac 459044 GGMPSSSkLGTGVSL transcription, inhibited 16012755 2 0 0 -Lima1 eplin Actin-binding; Cytoskeletal; Motility/polarity/chemotaxis Q9ERG0 65970 15 F1|15 56.13 cM mouse S360-p 455424 PMHPKPLsPDARTSS molecular association, regulation; intracellular localization cell motility, induced; cytoskeletal reorganization ACTB(DISRUPTS) 17875928 3 69 83 destabilization of stress fibres, membrane ruffle formation -RABEP1 RABEP1 Vesicle Q15276 9135 17p13.2 human S407-p 468548 DGLRRAQsTDSLGTS Rabaptin receptor recycling, induced cell motility, induced Rab4(INDUCES) 22975325 1 60 614 invasion into Matrigel; persistent directional migration; EGFR and integrin recycling - IGM P0DOX6 human K292-ub 1877089300 DQVQAEAkESGPTTY C1-set intracellular localization 32127472 1 1 0 localization in endoplasmic reticulum (ER) lumin -RPL13A RPL13A Ribosomal; Translation P40429 23521 19q13.33 human S77-p 5594501 PYHFRAPsRIFWRTV Ribosomal_L13 activity, induced; protein degradation; molecular association, regulation; ubiquitination translation, altered; translation, inhibited GAPDH(INDUCES) 18995835; 22771119 3 2 1 essential for GAIT-mediated translational silencing of inflammatory genes; Phosphorylation is required for RPLl3A release from ribosome. GAPDH binds to phosphorylated S77 and prevents degradation. -Trio TRIO Apoptosis; EC 2.7.11.1; GEF; GEF, misc.; KINASE; Kinase, protein; Protein kinase, CAMK; Protein kinase, Ser/Thr (non-receptor) NP_001101128 310192 2q22 rat Y2685-p 27425000 LLNPNYIyDVPPEFV activity, induced; molecular association, regulation cell growth, induced; cytoskeletal reorganization; signaling pathway regulation DCC(INDUCES) 23230270 1 0 0 netrin-1/DCC pathway; Rac1 activation induced; regulates DCC surface expression in the growth cone of cortical neurons; cortical axon extension -Foxc2 FOXC2 Apoptosis; Cell development/differentiation; DNA-binding; Transcription factor Q61850 14234 8 E1|8 70.33 cM mouse S124-p 36950200 NSIRHNLsLNECFVK Forkhead intracellular localization cell motility, inhibited; signaling pathway regulation 25486430 1 0 0 promotes cytoplasmic localization, CK2 signaling pathway regulation, decreased cell migration -AKAP13 AKAP13 Adaptor/scaffold; GEF; GEF, Rac/Rho; Nuclear export; Nuclear receptor co-regulator; Oncoprotein Q12802 11214 15q25.3 human T2467-p 487261 SLPRRAEtFGGFDSH molecular association, regulation 14-3-3 sigma(INDUCES) 36402225 1 24 299 -Foxo4 FOXO4 DNA-binding; Oncoprotein; Transcription factor Q9WVH3 54601 X D|X 43.89 cM mouse T32-p 455572 QSRPRSCtWPLPRPD molecular association, regulation transcription, altered 14-3-3 zeta(INDUCES) 14690436 6 8 34 -FGFR1 FGFR1 EC 2.7.10.1; KINASE; Kinase, protein; Membrane protein, integral; Oncoprotein; Protein kinase, TK; Protein kinase, tyrosine (receptor) P11362 2260 8p11.23 human Y766-p 447922 ALTSNQEyLDLSMPL molecular association, regulation; phosphorylation carcinogenesis, induced; cell growth, induced GPR89A(INDUCES); GRB2(INDUCES); ECSIT(INDUCES); PLCG1(INDUCES); GAB1(INDUCES); SHP-2(INDUCES); USP15(INDUCES) 1656221; 35574218 10 1 0 regulates phosphorylation of downstream proteins -CBLB Cbl-b Adaptor/scaffold; Calcium-binding; EC 6.3.2.-; Ligase; UBIQUITIN LIGASE; Ubiquitin conjugating system; Ubiquitin ligase Q13191 868 3q13.11 human Y133-p 50346901 KEGKERMyEEQSQDR Cbl_N ubiquitination; enzymatic activity, induced 26416283 1 0 0 -ARHGAP19 ARHGAP19 GAP; GAP, Rac/Rho Q14CB8 84986 10q24.1 human S422-p 3196670 QKRARSRsFSGLIKR molecular association, regulation 29420299 1 18 17 binding protects from dephosphorylation of the T404 and T476 residues; binding to 14-3-3 proteins -CAV1 caveolin-1 Adaptor/scaffold; Motility/polarity/chemotaxis; Nuclear receptor co-regulator P33724 403980 dog S80-p 448421 AEPEGTHsFDGIWKA Caveolin intracellular localization 11078729 3 0 0 phosphorylation of this site regulates secretion of caveolin-1 in the pancreatic acinar cells AR42J -Ffar4 GPR120 GPCR, family 1; Lipid-binding; Membrane protein, integral; Membrane protein, multi-pass; Receptor, GPCR Q7TMA4 107221 19|19 C2 mouse S350-p 31014808 GAIFTDTsVRRNDLS receptor internalization, induced; molecular association, regulation ARR3(INDUCES) 26873857; 32817367 5 1 0 -F11R JAM-A Cell adhesion; Membrane protein, integral Q9Y624 50848 1q23.3 human S284-p 467829 KVIYSQPsARSEGEF intracellular localization 11027562 5 51 19 -PARD3 PAR3-alpha Adaptor/scaffold; Motility/polarity/chemotaxis Q8TEW0 56288 10p11.22-p11.21 human Y1127-p 457508 GHMMDALyAQVKKPR molecular association, regulation cytoskeletal reorganization LIMK2(DISRUPTS) 17053785 2 25 175 -Wnk4 WNK4 EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, Other; Protein kinase, Ser/Thr (non-receptor) Q80UE6 69847 11|11 D mouse K223-ub 40323305 SEEVEMLkGLQHPNI Pkinase protein degradation 23576762 1 1 0 regulates electrolyte homeostasis and involved in Pseudohypoaldosteronism type II (PHAII) pathogenesis -Irs1 IRS1 Adaptor/scaffold; Motility/polarity/chemotaxis P35569 16367 1 C5|1 42.0 cM mouse Y608-p 447555 NLHTDDGyMPMSPGV neural plasticity 32075735 33 12 294 -YWHAB 14-3-3 beta Adaptor/scaffold P31946 7529 20q13.12 human K77-ac 31068005 KTERNEKkQQMGKEY 14-3-3 molecular association, regulation SYNPO(DISRUPTS) 23840712 1 0 0 -SMG9 SMG9 RNA processing Q9H0W8 56006 19q13.31 human Y41-p 10887902 PGGRERDyIAPWERE molecular association, regulation cytoskeletal reorganization IQGAP1(DISRUPTS) 21640080 1 2 67 -G3BP1 G3BP-1 Adaptor/scaffold; EC 3.6.4.12; EC 3.6.4.13; Helicase; RNA-binding Q13283 10146 5q33.1 human Y40-p 1877717200 FYGKNSSyVHGGLDS NTF2 molecular association, regulation G3BP-1(INDUCES) 35798143 1 0 0 -PFKM PFKM Carbohydrate Metabolism - fructose and mannose; Carbohydrate Metabolism - galactose; Carbohydrate Metabolism - glycolysis and gluconeogenesis; Carbohydrate Metabolism - pentose phosphate pathway; EC 2.7.1.11; Kinase, other P08237 5213 12q13.11 human S74-p 55569803 EATWESVsMMLQLGG PFK enzymatic activity, inhibited 27153534 1 1 0 -DAP3 DAP3 Apoptosis; Mitochondrial; Nuclear receptor co-regulator P51398 7818 1q22 human S215-p 2226204 YVWNKREsTEKGSPL DAP3 apoptosis, induced 18227431 1 1 0 -NOS3 eNOS Amino Acid Metabolism - arginine and proline; EC 1.14.13.39; Oxidoreductase P29474 4846 7q36.1 human S633-p 448637 WRRKRKEsSNTDSAG Flavodoxin_1 molecular association, regulation; enzymatic activity, induced signaling pathway regulation JNK1(DISRUPTS); ERK2(DISRUPTS); P38A(DISRUPTS) 23768697; 26598507; 35182051 28 12 7 PI3K-Akt-eNOS signaling pathway -ADRA1D ADRA1D GPCR, family 1; Membrane protein, integral; Membrane protein, multi-pass; Receptor, GPCR P25100 146 20p13 human T328-p 1424270005 MRSAKGHtFRSSLSV 7tm_1 receptor internalization, altered signaling pathway regulation 29551601 1 1 0 regulates ERK signaling pathway, induces calcium signaling de-sensitization -RAD52 RAD52 DNA repair, damage P43351 5893 12p13.33 human K406-ac 971232911 GNWESHRkSQDMKKR molecular association, regulation; intracellular localization DNA repair, induced RFA2(INDUCES); RPA3(INDUCES); RAD51(INDUCES); RPA1(INDUCES) 29590107 1 1 0 accumulation of RAD52 at DSB sites -Nrip1 RIP140 Nuclear receptor co-regulator; Transcription, coactivator/corepressor Q8CBD1 268903 16|16 C3.1 mouse K529-ac 459039 DIHSDGTkFSPQNYT NRIP1_repr_2 intracellular localization transcription, inhibited 15879431 0 2 0 -BRF1 GTF3B Transcription initiation complex Q92994 2972 14q32.33 human T270-p 22996307 RLTEFEDtPTSQLTI TFIIB molecular association, regulation cell cycle regulation; transcription, inhibited POLR3A(DISRUPTS) 22281053 1 0 0 -DCBLD2 DCBLD2 Cell adhesion; Membrane protein, integral Q96PD2 131566 3q12.1|3 human Y677-p 475112 LPITGPEyATPIIMD molecular association, regulation CRKL(INDUCES) 23770091 2 2 3 -RUNX1 AML1 DNA-binding; Oncoprotein; Transcription factor Q01196 861 21q22.12 human R206-me 2363103 SELEQLRrTAMRVSP molecular association, regulation cell differentiation, altered; transcription, induced SIN3A(DISRUPTS) DNA(DISRUPTS) 18316480 2 1 0 -Irgm1 IRGM EC 3.6.5.-; Endoplasmic reticulum; Hydrolase Q60766 15944 11|11 B1.2 mouse K275-ub 27194819 YEKIVGDkVAVWKQR IIGP protein degradation 35197566 1 2 0 -NADK2 NADK2 EC 2.7.1.23 Q4G0N4 133686 5p13.2 human K76-ac 25541818 SRVVVVAkTTRYEFE NAD_kinase enzymatic activity, induced 35868311 1 2 0 K76Q and K304Q mutants reduced proline production, K76Q and K304Q mutants and S116A showed reduced catalytic activity, phosphorylation, succinylation, or acetylation could generate a charge repulsion in the active site -Ulk1 ULK1 Autophagy; EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, Other; Protein kinase, Ser/Thr (non-receptor) O70405 22241 5|5 F mouse S913-p 10428808 KVAELLSsGLQTAID DUF3543 cell cycle regulation; autophagy, induced 34778891 1 2 0 -HRAS HRas G protein; G protein, monomeric; G protein, monomeric, Ras; Motility/polarity/chemotaxis; Oncoprotein P01112 3265 11p15.5 human T148-p 23113995 YIETSAKtRQGVEDA Ras protein degradation; molecular association, regulation; ubiquitination; phosphorylation carcinogenesis, inhibited; cell growth, inhibited; transcription, inhibited; signaling pathway regulation CTNNB1(DISRUPTS); BTRC(INDUCES) 22494971; 30413483 2 1 1 ERK phosphorylation, ERK pathway activation -NLRP3 NLRP3 Inhibitor Q96P20 114548 1q44 human T659-p 1871776517 KIEINLStRMDHMVS activity, induced; molecular association, regulation NEK7(INDUCES) 33432150 1 1 0 increased pro-IL-1? maturation; induce inflammasome activation -ESR1 ER-alpha DNA-binding; Nuclear receptor; Transcription factor P03372 2099 6q25.1-q25.2 human K266-ac 461005 RRGGRMLkHKRQRDD activity, induced; protein stabilization; molecular association, regulation cell growth, inhibited; cell motility, inhibited; transcription, induced; transcription, altered DNA(INDUCES) 16497729; 19887647; 24101509; 33544437 4 2 0 MOF depletion promotes proliferation, motility and invasion in HCC -NFATC1 NFAT2 DNA-binding; Transcription factor O95644 4772 18q23 human S161-p 56629001 TATLSLPsLEAYRDP cell growth, induced DNA(INDUCES) 27346349 2 1 0 -CCP110 CP110 Cell cycle regulation O43303 9738 16p12.3 human S366-p 9314148 GSYAKLPsPEPSMSP intracellular localization cell cycle regulation 12361598 1 17 3 -SLC4A4 SLC4A4 Membrane protein, integral; Membrane protein, multi-pass; Transporter; Transporter, SLC family Q9Y6R1 8671 4q13.3 human S232-p 4699755 ADIGKTVsSASRMFT Band_3_cyto protein conformation; activity, inhibited 30377224 1 9 5 -CAMK2A CAMK2A iso2 EC 2.7.11.17; KINASE; Kinase, protein; Protein kinase, CAMK; Protein kinase, Ser/Thr (non-receptor) Q9UQM7-2 815 5q32 human T306-p 449596 LKGAILTtMLATRNF molecular association, regulation; intracellular localization; enzymatic activity, inhibited; phosphorylation NMDAR2B(DISRUPTS) 28636948 18 10 2 inhibits phosphorylation at T286, regulates LTP, fear memory, spatial learning -Disc1 DISC1 Cell development/differentiation; Motility/polarity/chemotaxis Q811T9 244667 8 E2|8 73.26 cM mouse S710-p 18942700 QLQEAGSsPHAEDEE molecular association, regulation; intracellular localization cell motility, induced; signaling pathway regulation BBS1(INDUCES); BBS4(INDUCES); GSK3B(DISRUPTS) 21471969 1 2 0 -CDKN1B p27Kip1 Cell cycle regulation; Inhibitor; Oncoprotein; Protein kinase, regulatory subunit P46527 1027 12p13.1 human T198-p 448781 PGLRRRQt_______ protein degradation; protein stabilization; molecular association, regulation; ubiquitination; intracellular localization cell cycle regulation; carcinogenesis, inhibited; apoptosis, induced; cell motility, induced; transcription, induced; cell growth, altered 14-3-3 sigma(INDUCES); STMN1(INDUCES); 14-3-3 epsilon(INDUCES); CDK2(DISRUPTS); CDK4(INDUCES); 14-3-3 eta(INDUCES); JAK2(INDUCES); 14-3-3 theta(INDUCES) 12042314; 14504289; 15280662; 15743786; 17053782; 17237771; 18570873; 18593906; 19672859; 21423803; 23707388; 25684140; 26307683; 27197201; 33755959; 35108359 27 0 6 -DNMT3A DNMT3A Amino Acid Metabolism - cysteine and methionine; EC 2.1.1.37; METHYLTRANSFERASE; Methyltransferase; Methyltransferase, DNA Q9Y6K1 1788 2p23.3 human S390-p 17548178 LFPVCHDsDESDTAK methylation; intracellular localization; enzymatic activity, inhibited 25066127 1 6 0 decreases methylation of CpG -CHEK2 Chk2 EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, CAMK; Protein kinase, Ser/Thr (non-receptor); Tumor suppressor O96017 11200 22q12.1 human S456-p 981404 PEVWAEVsEKALDLV Pkinase protein degradation; ubiquitination apoptosis, induced 17715138 1 1 0 reduction in apoptotic response to DNA damage -DVL2 DVL2 Adaptor/scaffold; Motility/polarity/chemotaxis O14641 1856 17p13.1 human K484-ub 21173392 KYASGLLkAGLIRHT DEP molecular association, regulation; intracellular localization cell motility, induced; signaling pathway regulation Cofilin-1(INDUCES); VANGL1(INDUCES) 31340145 1 6 0 DVL2 variant with all encoded lysine residues mutated to arginine is sufficient to restore WNT activation -TRIM65 TRIM65 Ubiquitin conjugating system Q6PJ69 201292 17q25.1 human T413-p 1868914503 RCRLGPHtDNIGRGP SPRY carcinogenesis, inhibited; signaling pathway regulation 31332286 1 1 0 dephosphorylated form (6A mutant) contributes to TRIM65 function in tumor progression -DYRK1A DYRK1A EC 2.7.12.2; KINASE; Kinase, protein; Protein kinase, CMGC; Protein kinase, dual-specificity (non-receptor) Q13627 1859 21q22.13 human S529-p 475065 SNSGRARsDPTHQHR molecular association, regulation; enzymatic activity, induced 14-3-3 beta(INDUCES) 17229891 2 6 0 14-3-3 binding increases catalytic activity of DYRK1A. -SUMO3 SUMO3 Ubiquitin-like modifier P55854 6612 21q22.3 human K11-sm 2407412 EKPKEGVkTENDHIN protein processing signaling pathway regulation 12506199 3 8 0 decreases amyloidogenesis and increases nonamyloidogenic APP processing -ACTB ACTB Cytoskeletal; Motility/polarity/chemotaxis P60709 60 7p22.1 human K84-m1 31094539 TNWDDMEkIWHHTFY Actin molecular association, regulation cell cycle regulation; cytoskeletal reorganization; cell motility, inhibited MYH10(DISRUPTS) 23673617 1 1 0 -NFKBIB IkB-beta Inhibitor Q15653 4793 19q13.2 human S19-p 447917 DADEWCDsGLGSLGP protein degradation 8657102 6 0 0 -H2BC3 H2B DNA-binding P33778 3018 6p22.2 human K116-ac 480280 HAVSEGTkAVTKYTS molecular association, regulation polybromo 1(INDUCES) 20368734 1 5 8 varying site specificity binding for each bromodomain 1-6 -Epha3 EphA3 EC 2.7.10.1; KINASE; Kinase, protein; Membrane protein, integral; Protein kinase, TK; Protein kinase, tyrosine (receptor) P29319 13837 16|16 C1.3 mouse Y602-p 449913 TYVDPHTyEDPTQAV EphA2_TM carcinogenesis, altered; cell motility, altered 20697431 3 6 31 -ETV1 ETV1 DNA-binding; Oncoprotein; Transcription factor P50549 2115 7p21.2 human S191-p 3059602 HRFRRQLsEPCNSFP ETS_PEA3_N activity, induced transcription, induced 12213813 3 0 3 -FANCG FANCG DNA repair, damage O15287 2189 9p13.3 human S387-p 454240 PRFSPPPsPPGPCMP activity, induced 15367677 2 0 0 -HNF4A HNF4 alpha DNA-binding; Nuclear receptor; Transcription factor P41235 3172 20q13.12 human K127-ac 460634 CFRAGMKkEAVQNER zf-C4 molecular association, regulation; intracellular localization; protein conformation transcription, induced Exportin-1(DISRUPTS); CBP(INDUCES) DNA(INDUCES) 10882110 1 0 0 -SHC4 SHC4 Adaptor/scaffold Q6S5L8 399694 15q21.1 human Y403-p 474333 QATEQMAyCPIQCEK molecular association, regulation SHP-2(INDUCES) 28213521 2 1 1 -Pak2 PAK2 EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, STE; Protein kinase, Ser/Thr (non-receptor) Q64303 29432 11q22 rat T402-p 448300 PEQSKRStMVGTPYW Pkinase molecular association, regulation cytoskeletal reorganization N-WASP(INDUCES) 28972183 15 2 11 -RET Ret EC 2.7.10.1; KINASE; Kinase, protein; Membrane protein, integral; Oncoprotein; Protein kinase, TK; Protein kinase, tyrosine (receptor) P07949 5979 10q11.21 human Y687-p 449892 AQAFPVSySSSGARR molecular association, regulation; protein conformation; enzymatic activity, induced cell growth, altered SHP-2(INDUCES) 20682772; 28009299 4 4 27 -Erbb3 HER3 EC 2.7.10.1; KINASE; Kinase, protein; Membrane protein, integral; Oncoprotein; Protein kinase, TK; Protein kinase, tyrosine (receptor) Q62799 29496 7q11 rat Y1219-p 448639 GSLEELGyEYMDVGS molecular association, regulation; phosphorylation PIK3CB(INDUCES); PIK3R1(INDUCES) 11546794 5 0 1 induces phosphorylation of Akt1. -TNFRSF1A TNF-R1 Membrane protein, integral; Receptor, cytokine P19438 7132 12p13.31 human T417-p 11077252 RTPRREAtLELLGRV Death molecular association, regulation; phosphorylation apoptosis, induced; signaling pathway regulation GRB2(DISRUPTS) 32159413 1 1 3 decrease ERK, Akt and STAT3 phosphorylation; non-canonical TNF-alpha signaling, necrosis induced -PRKDC DNAPK DNA repair, damage; EC 2.7.11.1; KINASE; Kinase, protein; Nucleolus; Protein kinase, Ser/Thr (non-receptor); Protein kinase, atypical P78527 5591 8q11.21 human T2671-p 3193652 TDPLVDHtSPSSDSL DNAPKcs_CC5 DNA repair, inhibited 24687855 1 4 0 cell survival inhibited -Prkcd PKCD EC 2.7.11.13; KINASE; Kinase, protein; Nuclear receptor co-regulator; Protein kinase, AGC; Protein kinase, Ser/Thr (non-receptor); Protein kinase, tyrosine (non-receptor); Tumor suppressor P09215 170538 16p16 rat Y332-p 450077 IPDNNGTyGKIWEGS molecular association, regulation; enzymatic activity, induced apoptosis, induced SHC1(INDUCES) 12024011; 14715667; 17956904; 18550549 13 25 532 -Ppp1r12a MYPT1 Motility/polarity/chemotaxis; PHOSPHATASE; Protein phosphatase, regulatory subunit Q10728 116670 7q21 rat T855-p 452075 PREKRRStGVSFWTQ intracellular localization; activity, inhibited 19095646 44 2 17 -AR AR DNA-binding; Nuclear receptor; Transcription factor P10275 367 Xq12 human S258-p 449806 VEALEHLsPGEQLRG Androgen_recep transcription, altered 15684382 3 2 1 -VIM Vimentin Cytoskeletal; Motility/polarity/chemotaxis P08670 7431 10p13 human S10-p 455451 TRSVSSSsYRRMFGG Filament_head cell motility, altered 19291697 4 11 1 -TP53 p53 Activator; DNA-binding; Motility/polarity/chemotaxis; Nuclear receptor co-regulator; Transcription factor; Tumor suppressor P04637 7157 17p13.1 human S149-gl 5148303 PVQLWVDsTPPPGTR P53 protein stabilization; ubiquitination; phosphorylation 16964247 1 1 0 decreases p53 T155 phosphorylation; decreases p53 ubiquitination -GAB1 GAB1 Adaptor/scaffold; Motility/polarity/chemotaxis Q13480 2549 4q31.21 human Y447-p 449791 SEELDENyVPMNPNS molecular association, regulation SHP-2(INDUCES); PIK3R1(INDUCES) 10978177; 9658397 6 2 12 -Epg5 EPG5 Q80TA9 100502841 mouse K252-ub 27195508 PEVTPFTkEQLKLLE molecular association, regulation autophagy, induced LC3A(DISRUPTS) 30931944 1 3 0 -ESR1 ER-alpha DNA-binding; Nuclear receptor; Transcription factor P03372 2099 6q25.1-q25.2 human S212-p 12127402 CKAFFKRsIQGHNDY zf-C4 transcription, induced 22266331; 34157297 8 1 0 -H3C1 H3 DNA-binding P68431 8350 6p22.2 human K37-ac 3612525 PATGGVKkPHRYRPG Histone molecular association, regulation chromatin organization, altered DNA(DISRUPTS) 20720004 2 1 0 -WASF3 WASF3 Actin-binding; Motility/polarity/chemotaxis Q9UPY6 10810 13q12.13 human Y337-p 486450 LPAQIIEyYNPSGPP cell motility, induced; cytoskeletal reorganization 17623672 1 0 0 induces lamellipodia formation -PINK1 PINK1 EC 2.7.11.1; KINASE; Kinase, protein; Membrane protein, integral; Mitochondrial; Protein kinase, Other; Protein kinase, Ser/Thr (non-receptor) Q9BXM7 65018 1p36.12 human T257-p 25544600 AGEYGAVtYRKSKRG intracellular localization autophagy, induced; apoptosis, inhibited 23953109; 34706234 3 3 0 induces mitophagy; induces localization of PARK2 -Foxp3 FOXP3 C2H2-type zinc finger protein; Cell cycle regulation; DNA-binding; Transcription factor Q99JB6 20371 X A1.1|X 3.41 cM mouse T175-p 29672100 CTFPRSGtPRKDSNL protein degradation cell growth, induced; transcription, altered 23853094 1 1 0 alanine mutants of S19 or T175 inhibited (lL2) or induced (CD25) transcription of FOXP3 responsive genes, suppressed T cell proliferation, and showed an anti-inflamatory effect in a murine colitis model -RPTOR Raptor Adaptor/scaffold Q8N122 57521 17q25.3 human S791-p 1868515108 IDKMRRAsSYSSLNS activity, inhibited carcinogenesis, induced; cell growth, induced 32312749; 34673774 2 0 0 inhibits mTORC1 activity; mTORC1 activity inhibited -TBX3 TBX3 DNA-binding; Transcription factor O15119 6926 12q24.21 human S719-p 23151362 AEKEAATsELQSIQR protein stabilization; intracellular localization cell motility, induced; transcription, inhibited 25595898 1 0 1 TBX3 S719E promotes transcriptional repression of E-cadherin -FOXO3 FOXO3A Autophagy; DNA-binding; Oncoprotein; Transcription factor O43524 2309 6q21 human K271-ac 460595 RGRAAKKkAALQTAP intracellular localization apoptosis, induced 25981116 3 0 0 inhibits nuclear localization -Mcl1 MCL1 Apoptosis; Channel, misc.; Inhibitor; Membrane protein, integral; Mitochondrial P97287 17210 3 F2.1|3 40.74 cM mouse S102-p 1172400 SAAAAIVsPEEELDG protein degradation; molecular association, regulation PIN1(DISRUPTS) 17670986 7 4 0 -Tp53 p53 Activator; DNA-binding; Motility/polarity/chemotaxis; Nuclear receptor co-regulator; Transcription factor; Tumor suppressor P02340 22059 11 B3|11 42.83 cM mouse T21-p 447541 ELPLSQEtFSGLWKL P53_TAD activity, induced; protein stabilization; molecular association, regulation; intracellular localization cell cycle regulation; apoptosis, altered; transcription, altered MDM2(DISRUPTS); p300(INDUCES) 14555661; 16704422; 20818388 35 0 0 -Stip1 STI1 Chaperone Q60864 20867 19|19 A mouse S189-p 465575 LLGVDLGsMDEEEEA intracellular localization 14754904 2 0 0 -Lpp LPP Adaptor/scaffold; Cytoskeletal; Motility/polarity/chemotaxis Q8BFW7 210126 16|16 B1 mouse Y403-p 3414611 HLTKKMLyDMENPPA cell cycle regulation; cell motility, altered 18515860 0 2 7 -AKT1S1 PRAS40 Apoptosis Q96B36 84335 19q13.33 human S203-p 454572 KRTEARSsDEENGPP PRAS molecular association, regulation cell growth, induced; autophagy, inhibited 14-3-3 beta(INDUCES); Raptor(DISRUPTS) 26876154 2 50 119 activates mTORC1 -MSH3 MSH3 DNA repair, damage P20585 4437 5q14.1 human K99-ac 9925427 ENDGPVKkKVKKVQQ intracellular localization 32900932 1 0 1 -HOXA11 HOXA11 DNA-binding; Transcription factor P31270 3207 7p15.2 human S98-p 55571505 RDCLQAPsAAGVPGD DUF3528 molecular association, regulation transcription, induced CBP(INDUCES) 27239043 1 1 0 -CAV2 caveolin-2 Adaptor/scaffold; Motility/polarity/chemotaxis P51636 858 7q31.2 human Y19-p 450198 LFMDDDSySHHSGLE Caveolin molecular association, regulation; intracellular localization; phosphorylation cell growth, induced; cell adhesion, induced; transcription, inhibited; signaling pathway regulation RASA1(INDUCES); ERK1(INDUCES); caveolin-1(INDUCES) 12091389; 15504032; 20455999; 22819829; 29371975 10 10 28 -Adam17 TACE EC 3.4.24.86; Membrane protein, integral; Motility/polarity/chemotaxis; Protease Q9Z0F8 11491 12 A1.3|12 8.3 cM mouse T735-p 449804 KPFPAPQtPGRLQAL activity, induced; molecular association, regulation; intracellular localization; enzymatic activity, induced carcinogenesis, induced; signaling pathway regulation FAK(INDUCES) 15923650; 29361535; 32197276; 32241917 18 15 6 induces sheddase activity; cell surface localization, TGFB1 upregulation ; induces Prss14/Epithin ectodomain shedding; T735A mutation induced altered localization of TACE. Wild-type TACE colocalized with calregulin an ER marker. T735E colocalizes with components of the protein secretory pathway. ; Astagaloside-III-dependent EGFR-pathway activation -SQSTM1 SQSTM1 Autophagy; Nuclear receptor co-regulator; Ubiquitin conjugating system Q13501 8878 5q35.3 human K189-ub 12312680 SRWLRKVkHGHFGWP autophagy, induced 27880896 1 3 11 antibacterial autophagy -MAP2K6 MKK6 EC 2.7.12.2; KINASE; Kinase, protein; Protein kinase, STE; Protein kinase, dual-specificity (non-receptor) P52564 5608 17q24.3 human S207-ac 4325701 ISGYLVDsVAKTIDA Pkinase enzymatic activity, inhibited; phosphorylation 16728640 2 0 0 yopJ inhibits MKK6 phosphorylation and its enzymatic activation in vitro -FADD FADD Adaptor/scaffold; Apoptosis Q13158 8772 11q13.3 human S203-p 22496704 MSWNSDAsTSEAS__ phosphorylation apoptosis, induced 21978935 1 1 0 enhances S194 phosphorylation; apoptosis and necrosis -GUCY1B1 GUCY1B1 EC 4.6.1.2; Guanylyl cyclase; Lyase; Nucleotide Metabolism - purine; Receptor, misc. Q02153 2983 4q32.1 human Y192-p 469612 ESKEEDFyEDLDRFE molecular association, regulation Src(INDUCES); Fyn(INDUCES) 16079134 3 0 0 -BOD1 BOD1 Q96IK1 91272 5q35.2 human T95-p 384464301 KVDNFVStHLDKQEW COMPASS-Shg1 cell cycle regulation 29142109 1 0 0 -Hdac1 HDAC1 DEACETYLASE; Deacetylase; EC 3.5.1.98; Hydrolase; Nuclear receptor co-regulator Q4QQW4 297893 5q36 rat K476-sm 2407422 KPEAKGVkEEVKMA_ molecular association, regulation neural plasticity; apoptosis, inhibited CREB iso1(DISRUPTS) 28186506 3 3 0 sumoylation rescues synaptic and memory deficits, and reduces amyloid plaque and apoptosis in APP/PS1 mice; Sumoylation increases CREB binding to DNA and mediates A? induction of Mcl-1 expression -Ptk2 FAK EC 2.7.10.2; KINASE; Kinase, protein; Protein kinase, TK; Protein kinase, tyrosine (non-receptor) O35346 25614 7q34 rat S722-p 447962 PSRPGYPsPRSSEGF molecular association, regulation; intracellular localization 12732587; 16373587 9 18 0 -POLH POLH DNA repair, damage; EC 2.7.7.7; Transferase Q9Y253 5429 6p21.1 human K682-sm 1877365920 SAVSHQGkRNPKSPL enzymatic activity, inhibited 32350109 1 1 0 -Nfatc4 NFAT3 DNA-binding; Transcription factor Q8K120 73181 14|14 C3 mouse S676-p 455348 SNGRRKRsPTQSFKF RHD_dimer activity, induced; intracellular localization transcription, altered 18086672 2 0 0 -TRPC6 TRPC6 Channel, cation; Membrane protein, integral; Membrane protein, multi-pass Q9Y210 7225 11q22.1 human S322-p 3363401 KNDYKKLsMQCKDFV activity, inhibited 19961855 5 0 0 suppresses TRPC6 channel current, G-alpha agonist-induced NFAT activation and myocyte hypertrophic responses -RASA1 RASA1 GAP; GAP, Ras; Motility/polarity/chemotaxis; Oncoprotein P09851 282032 cow Y457-p 449959 AVDGKEIyNTIRRKT molecular association, regulation DOK1(INDUCES) 7503985 3 6 38 -PXN PXN Adaptor/scaffold; Cell adhesion; Cytoskeletal; Motility/polarity/chemotaxis P49024 395832 chicken S188-p 471382 HYVIPESsSSAGGKA Paxillin protein stabilization cell motility, altered 17121676 2 1 0 promotes cell spreading by increasing the dynamics of membrane protrusions -SLC12A1 NKCC2 Membrane protein, integral; Membrane protein, multi-pass; Transporter; Transporter, SLC family P55015 100328575 rabbit T117-p 459122 KIEYYRNtGSVSGPK AA_permease_N activity, induced 16077079 4 2 0 -Mapk1 ERK2 EC 2.7.11.24; KINASE; Kinase, protein; Protein kinase, CMGC; Protein kinase, Ser/Thr (non-receptor) P63086 116590 11q23 rat Y185-p 447594 HTGFLTEyVATRWYR Pkinase activity, induced; molecular association, regulation; intracellular localization; enzymatic activity, induced cytoskeletal reorganization; signaling pathway regulation; cell growth, altered MEK1(INDUCES) 10473611; 10567369; 11731096; 12163549; 14627993; 16368189; 19427337; 19943942; 20096547; 21357465; 21660950; 21738764; 21917714 1163 158 4003 quercetin and myricetin-induced cardioprtection signaling; regulate cell proliferation in dentate gyrus following ischemia; Arginine methyltransferase 5 induced signaling for cell proliferation and differentiation; focal adhesion inhibition/dissociation; integrin Rac1-NADPH oxidase signaling -SLC12A6 KCC3 Membrane protein, integral; Membrane protein, multi-pass; Transporter; Transporter, SLC family Q9UHW9 9990 15q14 human T1048-p 4770548 YQEKVHMtWTKDKYM SLC12 activity, inhibited 19665974; 24043619; 27782176 6 10 0 acute cell swelling; Regulates the cotransporter activity -NR2F6 EAR-2 DNA-binding; Nuclear receptor P10588 2063 19p13.11 human S83-p 25802106 CKSFFKRsIRRNLSY zf-C4 transcription, induced DNA(DISRUPTS) 18701084 1 0 0 -NOTCH1 Notch 1 Membrane protein, integral; Motility/polarity/chemotaxis; Oncoprotein; Receptor, misc.; Transcription factor P46531 4851 9q34.3 human K2157-ac 18899504 KPGVQGKkVRKPSSK intracellular localization cell growth, induced; apoptosis, inhibited 28377411 2 1 0 -Phb1 PHB Apoptosis; Cell cycle regulation; Chaperone; Mitochondrial; Motility/polarity/chemotaxis; Nuclear receptor co-regulator; Oncoprotein; Transcription, coactivator/corepressor P67778 18673 11 59.01 cM|11 D mouse Y114-p 6374001 YTSIGEDyDERVLPS Band_7 molecular association, regulation; intracellular localization; phosphorylation; enzymatic activity, induced transcription, induced; signaling pathway regulation FCER1G(INDUCES) 24023254; 35219912 6 1 0 FCER1G and Syk-mediated signaling, increases antigen-induced mast cell degranulation; induces STAT6 phosphorylation, regulates ERK and STAT6 signaling, induces arginase activity -LRRFIP2 LRRFIP2 Unknown function Q9Y608 9209 3p22.2 human S202-p 20573501 SGLLRSAsLASLYNG activity, induced; molecular association, regulation signaling pathway regulation MYD88(INDUCES) 21220426 1 1 0 Increase NF-kB activity and regulates TLR4 signaling -UBAP2L NICE-4 RNA-binding; Ubiquitin conjugating system Q14157 9898 1q21.3 human S454-p 452474 AAPPPPSsPLPSKST cell growth, induced; autophagy, inhibited 37062825 2 48 2 -Des desmin Cytoskeletal; Motility/polarity/chemotaxis P31001 13346 1 C4|1 38.85 cM mouse S6-p 478272 __MSQAYsSSQRVSS transcription, altered; cell growth, altered 17381546 1 0 1 important for cardiomyogenesis -Oprm1 MOR-1 GPCR, family 1; Membrane protein, integral; Membrane protein, multi-pass; Receptor, GPCR P42866 18390 10 A1|10 1.85 cM mouse T370-p 447785 SARIRQNtREHPSTA receptor internalization, induced; receptor desensitization, induced; molecular association, regulation; receptor recycling, induced endocytosis, induced; signaling pathway regulation ARRB2(INDUCES) 21449911; 22725608; 25801029; 30018083; 32234959 19 5 0 regulates B-arrestin signaling -IRS1 IRS1 Adaptor/scaffold; Motility/polarity/chemotaxis P35568 3667 2q36.3 human S323-p 451399 MVGGKPGsFRVRASS phosphorylation 16611834 12 17 3 S323A has increased DOG-uptake and increased IRS-1 pTyr in +insulin. -MYD88 MYD88 Adaptor/scaffold Q99836 4615 3p22.2 human Y257-p 474538 KRLIPIKyKAMKKEF TIR molecular association, regulation signaling pathway regulation JAK2(INDUCES) 36172386 4 0 0 induces JAK2-STAT3 signaling -SREBF1 SREBP-1 iso3 DNA-binding; Membrane protein, integral; Membrane protein, multi-pass; Transcription factor P36956-3 6720 17p11.2 human S410-p 6729302 PPPSDAGsPFQSSPL protein degradation; activity, inhibited 19126544 1 0 0 -Pard3 PAR3-alpha Adaptor/scaffold; Motility/polarity/chemotaxis Q99NH2 93742 8 E2|8 74.66 cM mouse S885-p 455653 LGLKKSSsLESLQTA protein degradation 29464029 4 1 0 -KCNJ12 KCNJ12 Membrane protein, integral; Membrane protein, multi-pass Q14500 3768 17p11.2 human T354-p 3053611 KTYEVPStPRCSAKD IRK_C activity, inhibited 12234954 1 0 4 -Src Src EC 2.7.10.2; KINASE; Kinase, protein; Oncoprotein; Protein kinase, TK; Protein kinase, tyrosine (non-receptor) P05480 20779 2 H1|2 78.35 cM mouse Y133-p 2261000 LSTGQTGyIPSNYVA SH3_1 cell cycle regulation; cell growth, altered 8663329 2 0 0 -Dyrk1a DYRK1A EC 2.7.12.2; KINASE; Kinase, protein; Protein kinase, CMGC; Protein kinase, dual-specificity (non-receptor) Q61214 13548 16 C4|16 55.3 cM mouse Y145-p 449566 DGYDDDNyDYIVKNG intracellular localization cell cycle regulation; cell differentiation, altered 21878370 1 30 877 -MYC Myc DNA-binding; Nucleolus; Oncoprotein; Transcription factor P01106 4609 8q24.21 human K404-sm 40724409 PELENNEkAPKVVIL HLH protein degradation; ubiquitination transcription, inhibited 25895136 1 2 0 -HNRNPU hnRNP U DNA-binding; Nuclear receptor co-regulator; RNA splicing; RNA-binding; Spliceosome Q00839 3192 1q44 human S26-p 476219 ELKKRRLsDKGLKAE SAP molecular association, regulation; intracellular localization cell cycle regulation; chromatin organization, altered DNA(DISRUPTS) 33053167 1 16 61 -Oprm1 MOR-1 GPCR, family 1; Membrane protein, integral; Membrane protein, multi-pass; Receptor, GPCR P42866 18390 10 A1|10 1.85 cM mouse S375-p 447784 QNTREHPsTANTVDR receptor internalization, induced; receptor desensitization, induced; molecular association, regulation; phosphorylation endocytosis, induced; signaling pathway regulation ARRB2(INDUCES) 21449911; 21868358; 22725608; 23239825; 24629717; 30018083; 32234959 24 5 0 regulates B-arrestin signaling -TARBP2 TRBP Motility/polarity/chemotaxis; RNA processing; RNA-binding; Translation Q15633 6895 12q13.13 human S286-p 56757901 LRSCSLGsLGALGPA molecular association, regulation transcription, induced P70S6KB(DISRUPTS) 27407113 1 1 0 miRNA expression -ADRA1B ADRA1B GPCR, family 1; Membrane protein, integral; Membrane protein, multi-pass; Receptor, GPCR P18841 101843941 hamster S400-p 451003 GSLERSQsRKDSLDD receptor desensitization, altered 9353340 1 0 1 -LARP7 LARP7 RNA-binding Q4G0J3 51574 4q25 human T440-p 1869962000 ANREECRtQEKVNAT protein degradation; molecular association, regulation; ubiquitination cell cycle regulation; carcinogenesis, induced; DNA repair, induced BARD1(INDUCES) 32726637 1 0 0 -LTB4R LTB4R GPCR, family 1; Membrane protein, integral; Membrane protein, multi-pass; Receptor, GPCR Q15722 1241 14q12 human S320-p 4700741 SSTRRGGsLGQTARS phosphorylation signaling pathway regulation 30131369 1 5 0 phosphorylation of LTB4R basal phosphorylation site; chemotaxis, B-hexisaminidase release, regulates LTB4R function -CACNA1C CACNA1C Channel, calcium; Membrane protein, integral; Membrane protein, multi-pass Q13936 775 12p13.33 human S1981-p 455278 ASLGRRAsFHLECLK activity, induced 22100296; 22310722; 31759979 31 3 0 Ca-v1.2 channel activity induced -ADRA1B ADRA1B GPCR, family 1; Membrane protein, integral; Membrane protein, multi-pass; Receptor, GPCR P18841 101843941 hamster S394-p 451002 RPWTRGGsLERSQSR receptor desensitization, altered 9353340 1 0 0 -ESR1 ER-alpha DNA-binding; Nuclear receptor; Transcription factor P03372 2099 6q25.1-q25.2 human T311-p 449929 NSLALSLtADQMVSA activity, induced; molecular association, regulation; intracellular localization transcription, altered SRC-2(NOT_REPORTED); SRC-1(NOT_REPORTED); EGFR(DISRUPTS) 12138194; 23216744; 26079946 7 0 0 -Trp53 p53 iso2 Activator; DNA-binding; Motility/polarity/chemotaxis; Nuclear receptor co-regulator; Transcription factor; Tumor suppressor Q80ZA1 22059 11 B3|11 42.83 cM mouse K375-sm 1869726221 RAFQALIkEESPNC_ protein stabilization; intracellular localization apoptosis, induced; transcription, induced 23696846 1 0 0 -BCAR1 P130Cas Adaptor/scaffold; Motility/polarity/chemotaxis P56945 9564 16q23.1 human Y128-p 448778 SKAQQGLyQVPGPSP phosphorylation carcinogenesis, induced; cell motility, induced; cell growth, induced; cell adhesion, altered 22710723; 27447856 4 27 797 pY88 paxillin activates p130cas-PI3K-AKT signaling axis. -PKN2 PKN2 EC 2.7.11.13; KINASE; Kinase, protein; Protein kinase, AGC; Protein kinase, Ser/Thr (non-receptor) Q16513 5586 1p22.2 human T814-p 3253564 GMGYGDRtSTFCGTP Pkinase enzymatic activity, induced 19723632 1 4 73 -HOXB9 HOXB9 DNA-binding P17482 3219 17q21.32 human K27-ac 58948902 SEDAPPAkFPSGQYA Hox9_act carcinogenesis, inhibited; cell growth, inhibited; cell motility, inhibited; transcription, inhibited 27613418 1 1 0 -TP63 p63 DNA-binding; Transcription factor Q9H3D4 8626 3q28 human S477-p 7643500 NSMNKLPsVSQLINP protein degradation 19282665 1 0 0 DLX3-mediated degradation -Irf8 IRF8 DNA-binding; Transcription factor P23611 15900 8 E1|8 70.05 cM mouse Y107-p 2299204 QLDISEPyKVYRIVP IRF molecular association, regulation transcription, induced IRF8(INDUCES); PU.1(INDUCES); IRF2(INDUCES) 17200120 2 0 0 -Stat5b STAT5B DNA-binding; Oncoprotein; Transcription factor P52632 25126 10q31 rat Y679-p 449034 DRPKDEVySKYYTPV intracellular localization transcription, altered 12621061 1 0 0 -FEZ1 FEZ1 Q99689 9638 11q24.2 human S58-p 454522 SEIISFKsMEDLVNE FEZ molecular association, regulation; intracellular localization; protein conformation transcription, induced KIF5B(INDUCES); HSC70(DISRUPTS) 27247180; 28930676; 35172151 3 7 0 unphosphorylated FEZ1 is aggregated and colocalizes with Reelin; regulates localization of DNAPK; required for FEZ1 to promote HIV-1 uncoating and infection -KIT Kit EC 2.7.10.1; KINASE; Kinase, protein; Membrane protein, integral; Oncoprotein; Protein kinase, TK; Protein kinase, tyrosine (receptor) P10721 3815 4q12 human S741-p 450035 TKADKRRsVRIGSYI PK_Tyr_Ser-Thr enzymatic activity, inhibited; phosphorylation 7539802 1 0 0 -GLI1 GLI1 C2H2-type zinc finger protein; Oncoprotein; Transcription factor P08151 2735 12q13.3 human K815-sm 1873076606 HYGQVQVkPEQGCPV protein stabilization; ubiquitination; intracellular localization cell growth, induced; transcription, induced; signaling pathway regulation 28630282 1 0 0 inhibits ubiquitination, enhances Shh signaling -Esrp2 RBM35B RNA-binding Q8K0G8 77411 8|8 D3 mouse K413-ub 52473102 QAALRRHkGMLGKRY carcinogenesis, inhibited; RNA splicing, induced; cell growth, inhibited 26522722 1 0 0 -AFAP1L2 AFAP1L2 Activator; Cell cycle regulation Q8N4X5 84632 10q25.3 human Y54-p 462131 SSSSDEEyIYMNKVT molecular association, regulation PIK3R1(INDUCES) 19060924 1 5 176 -KAT5 Tip60 ACETYLTRANSFERASE; Acetyltransferase; EC 2.3.1.48; Nuclear receptor co-regulator; Nucleolus Q92993 10524 11q13.1 human K150-ac 52498004 NHRSTKRkVEVVSPA protein degradation; intracellular localization apoptosis, altered 25301942 1 0 0 HDAC3 increased the TIP60 half-life, and the ubiquitination level of TIP60, nuclear localization, cytoplasm and nucleus with HDAC3 expressed, TIP60 deacetylation increases its resistance to apoptosis -Syngap1 SynGAP iso3 GAP; GAP, Ras Q9QUH6-3 192117 20p12 rat S407-p 18710210 GKAKDFLsDMAMSEV RasGAP molecular association, regulation; intracellular localization HRas(INDUCES) 21382555 1 1 1 -Ppp1r1b DARPP-32 Motility/polarity/chemotaxis; Protein phosphatase, regulatory subunit Q60829 19049 11|11 D mouse T75-p 448048 RPNPCAYtPPSLKAV DARPP-32 activity, induced; enzymatic activity, induced 11572969; 16123776; 17301223 38 6 16 Phosphorylation of S566 is necessary for PP2A enzymatic activation and dephosphorylation of DARPP.; Mutation of T75 impaired a specific behavioral response (locomotor sensitization) to repeated cocaine administration. -CD19 CD19 Cell surface; Membrane protein, integral P15391 930 16p11.2 human Y348-p 454081 GSGPQNQyGNVLSLP activity, induced; molecular association, regulation SOS1(INDUCES); GRB2(INDUCES) 10706702 1 3 17 -FOCAD FOCAD Membrane protein, integral; Membrane protein, multi-pass Q5VW36 54914 9p21.3 human K587-ub 27195516 QWEKLIAkAASIRDI DUF3730 protein degradation 36184622 0 5 0 -Camk2b CAMK2B EC 2.7.11.17; KINASE; Kinase, protein; Protein kinase, CAMK; Protein kinase, Ser/Thr (non-receptor) P08413 24245 14q21 rat S331-p 48915803 ATMSTAAsGTTMGLV molecular association, regulation 26291163 1 1 0 inhibits interaction with F-actin, regulates synaptic plasticity -HECTD3 HECTD3 EC 6.3.2.-; EC 6.3.2.19; Ligase; UBIQUITIN LIGASE; Ubiquitin conjugating system; Ubiquitin ligase Q5T447 79654 1p34.1 human T157-p 150180307 ARLVPIDtPNHLQRQ molecular association, regulation apoptosis, inhibited CASP9(INDUCES) 28716524 1 1 0 -GRIK2 GluR6 Channel, calcium; Channel, ligand-gated; Membrane protein, integral; Membrane protein, multi-pass Q13002 2898 6q16.3 human C871-pa 27247800 ELRMSLKcQRRLKHK sumoylation; intracellular localization; phosphorylation; palmitoylation endocytosis, altered 37868810 2 0 0 palmitoylation maintains surface expression and regulates agonist -induced internalisation -JAK2 JAK2 EC 2.7.10.2; KINASE; Kinase, protein; Oncoprotein; Protein kinase, TK; Protein kinase, tyrosine (non-receptor) O60674 3717 9p24.1 human Y813-p 451492 NSLFTPDyELLTEND molecular association, regulation; phosphorylation APS(INDUCES); SH2-B-beta(INDUCES) 15767667; 16914724; 17565041 8 3 2 JAK2 Y1007/8 phosphorylation -Atoh1 ATOH1 Cell development/differentiation; DNA-binding; Transcription factor P48985 11921 6 C1|6 30.03 cM mouse S334-p 57761903 TSPRSHRsDGEFSPH protein degradation; molecular association, regulation; ubiquitination HUWE1(INDUCES) 27542412 1 1 0 -MTLN MTLN Membrane protein, integral Q8NCU8 205251 2q13 human T49-p 1881596600 LQDKLAAtQKKLDLA molecular association, regulation; intracellular localization Jun(DISRUPTS); NAT14(DISRUPTS) 36804379 1 0 0 -Prkdc DNAPK DNA repair, damage; EC 2.7.11.1; KINASE; Kinase, protein; Nucleolus; Protein kinase, Ser/Thr (non-receptor); Protein kinase, atypical P97313 19090 16 10.09 cM|16 A2 mouse S2053-p 455794 VQSYSYSsQDRKPTT DNAPKcs_CC3 DNA repair, induced Ku80(INDUCES) 28329681; 37307443 53 4 3 promoting S2053 phosphorylation; contributes to the synergy between XLF and DNA-PKcs in end-ligation, sites have distinct moderate roles in NHEJ -MKNK1 Mnk1 iso2 EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, CAMK; Protein kinase, Ser/Thr (non-receptor); Translation Q9BUB5-2 8569 1p33 human T209-p 447621 NSCTPITtPELTTPC Pkinase intracellular localization; enzymatic activity, induced 17590453 14 1 1 Leaves nucleus to cytoplasm upon phosphorylation. -SIK3 QSK EC 2.7.11.1; KINASE; Kinase, protein; Motility/polarity/chemotaxis; Protein kinase, CAMK; Protein kinase, Ser/Thr (non-receptor) Q9Y2K2 23387 11q23.3 human T469-p 480134 YLSMRRHtVGVADPR molecular association, regulation transcription, induced 14-3-3 beta(INDUCES) 22588126; 26048985 3 24 141 -GATA1 GATA1 DNA-binding; Transcription factor P15976 2623 Xp11.23 human S26-p 451232 VDPALVSsTPESGVF activity, induced transcription, induced 20101202 6 0 0 enhances survivin expression -MAPKAPK5 MAPKAPK5 EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, CAMK; Protein kinase, Ser/Thr (non-receptor); Tumor suppressor Q8IW41 8550 12q24.12-q24.13 human T182-p 450093 IDQGDLMtPQFTPYY Pkinase enzymatic activity, induced cell growth, altered 17254968; 20734105 6 10 94 -E2F1 E2F1 DNA-binding; Transcription factor Q01094 1869 20q11.22 human R109-me 57676506 AESSGPArGRGRHPG protein stabilization; molecular association, regulation; methylation cell cycle regulation; cell growth, inhibited; apoptosis, induced; transcription, induced DNA(INDUCES) 24076217 1 1 0 inhibits symmetrical methylation -IL5RA IL5RA Membrane protein, integral; Receptor, cytokine Q01344 3568 3p26.2 human K383-ub 1883407600 PAPKSNIkDLFVTTN protein degradation cell differentiation, inhibited 35982175 1 0 0 translocation to and degradation in lysosomes, March2/3 negatively regulates eosinophil maturation, March2/3 de?ciency promotes eosinophilic airway in?ammation -NINL Nlp Cell cycle regulation; Microtubule-binding Q9Y2I6 22981 20p11.21 human S185-p 15668109 WDSEDFGsPQKSCSP protein degradation; molecular association, regulation; protein stabilization; ubiquitination; intracellular localization cell cycle regulation PLK1(INDUCES) 20864540; 20890132 2 0 0 -S100A4 S100A4 Calcium-binding; Cell development/differentiation P26447 6275 1q21.3 human K22-sm 25352007 TFHKYSGkEGDKFKL S_100 intracellular localization transcription, induced 20685652 1 0 0 -SYN1 SYN1 Vesicle P17599 281510 cow Y301-p 478277 VVALTKTyATTEPFI Synapsin_C molecular association, regulation SYN1(INDUCES) 20530578 2 0 2 increases SYN1 oligomerization -SNX8 SNX8 Q9Y5X2 29886 7p22.3 human Y95-p 348335702 LFLKHVEyEVSSQRF molecular association, regulation transcription, induced IKKB(INDUCES) 29180417 1 0 0 -RUVBL1 RUVBL1 EC 3.6.4.12; Helicase; Motility/polarity/chemotaxis Q9Y265 8607 3q21.3 human K225-sm 2798313 EEYVPLPkGDVHKKK TIP49 intracellular localization cell growth, induced; transcription, induced 18087039 1 1 0 -NCOA3 SRC-3 ACETYLTRANSFERASE; Acetyltransferase; EC 2.3.1.48; Motility/polarity/chemotaxis; Nuclear receptor co-regulator; Transcription, coactivator/corepressor Q9Y6Q9 8202 20q13.12 human K1194-sm 3817000 SRQALELkMENPTAG transcription, inhibited 16760465 1 0 0 -Cacna1c CACNA1C Channel, calcium; Membrane protein, integral; Membrane protein, multi-pass P22002 24239 4q42 rat S1927-p 455278 ASLGRRAsFHLECLK CAC1F_C activity, induced; molecular association, regulation; intracellular localization; activity, inhibited PPP2CA(INDUCES); ITGB1(INDUCES) 16519540; 16554304; 17640527; 19478199; 21178109; 29180451; 34431981 31 3 0 membrane expression and distribution of CACNA1C along the dendrites of hippocampal neurons; differentially regulates the surface traffic of CACNA1C; regulates Cav1.2 channel gating -H3C1 H3 DNA-binding P68431 8350 6p22.2 human K4-m1 1458622 ____ARTkQTARKST Histone acetylation; molecular association, regulation; intracellular localization cell cycle regulation; carcinogenesis, inhibited; apoptosis, induced; cell growth, inhibited; transcription, induced; chromatin organization, altered; cell differentiation, induced; transcription, inhibited FOXA2(INDUCES); CHD-7(INDUCES); RBBP4(DISRUPTS); FALZ iso4(INDUCES); FALZ(INDUCES); STAT1(INDUCES); ING4(INDUCES) 15620353; 16728976; 17363312; 18787082; 19021773; 19187765; 19251738; 19805358; 20548336 44 10 9 -FSCN1 fascin Actin-binding; Cytoskeletal; Motility/polarity/chemotaxis Q16658 6624 7p22.1 human S38-p 3197465 FKVNASAsSLKKKQI Fascin cell growth, inhibited; cytoskeletal reorganization; cell motility, inhibited 28251354 1 7 0 reduce cell proliferation, cell migration and ?lopodia formation -MDM2 MDM2 EC 6.3.2.-; EC 6.3.2.19; Inhibitor; Ligase; NEDDYLATION LIGASE; Neddylation Ligase; Nucleolus; Oncoprotein; UBIQUITIN LIGASE; Ubiquitin conjugating system; Ubiquitin ligase Q00987 4193 12q15 human K446-sm 2793915 VICQGRPkNGCIVHG zf-C3HC4_3 protein degradation; protein stabilization; ubiquitination; enzymatic activity, induced apoptosis, inhibited 10892746 1 0 0 prevents ubiquitination of itself and induces ubiquitination of p53 thus stabilizing itself but causing degradation of p53 -CD274 PD-L1 Membrane protein, integral Q9NZQ7 29126 9p24.1 human Y112-p 1015586 KLQDAGVyRCMISYG V-set protein stabilization; molecular association, regulation ITM1(INDUCES) 31305264 1 1 0 glycosylation, prevents ubiquitination -Crebbp CBP ACETYLTRANSFERASE; Acetyltransferase; DNA-binding; EC 2.3.1.48; Motility/polarity/chemotaxis; Nuclear receptor co-regulator; Transcription, coactivator/corepressor P45481 12914 16 A1|16 2.4 cM mouse S2015-p 455574 QVSGPVMsSMPPGQW Creb_binding transcription, induced 15006641 1 0 0 -IKBKB IKKB EC 2.7.11.10; KINASE; Kinase, protein; Protein kinase, Other; Protein kinase, Ser/Thr (non-receptor) O14920 3551 8p11.21 human S750-p 5014910 QTEEEEHsCLEQAS_ O-GlcNAc glycosylation; molecular association, regulation; enzymatic activity, inhibited IKKG(DISRUPTS) 18957422; 19202066 2 0 0 S750 phosphorylation inhibits S733 O-GlcNAc and IKKB activity -PTPN6 SHP-1 EC 3.1.3.48; Motility/polarity/chemotaxis; PHOSPHATASE; Protein phosphatase, tyrosine (non-receptor) P29350 5777 12p13.31 human S591-p 454019 DKEKSKGsLKRK___ enzymatic activity, inhibited; protein conformation; phosphorylation carcinogenesis, inhibited 35258455 9 2 15 inhibits VAV1 dephosphorylation -TP53 p53 Activator; DNA-binding; Motility/polarity/chemotaxis; Nuclear receptor co-regulator; Transcription factor; Tumor suppressor P04637 7157 17p13.1 human K370-ac 458981 RAHSSHLkSKKGQST molecular association, regulation; protein stabilization; intracellular localization cell growth, inhibited; apoptosis, induced; transcription, induced; transcription, inhibited; transcription, altered BCL2L2(INDUCES); p21Cip1(DISRUPTS) DNA(INDUCES) 11099047; 11250899; 12421820; 14982997; 16291740; 18485870; 18697203; 19339993; 19377469; 21297583; 31680191; 34798143; 36257192; 9288740 22 3 0 promoting the C-terminal acetylation of p53 and may facilitate p53-dependent gene expression ; 20, 164, 305, 320, 370/372/373, 381/382/386 K-R mutants diminsished transactivation, and selective regulation of target genes expression through distinct mechanisms; arsenic induced overexpression of PUMA, P53 phosphorylation and acetylation, activation and accumulation of p53, PUMA disruption of Bcl-X complexes with pro-survival proteins resulting in apoptosis ; ZNF420 (Apak) represses p53 activity by attenuating its acetylation -PRAG1 SGK223 EC 2.7.10.2; KINASE; Kinase, protein; Motility/polarity/chemotaxis; Protein kinase, Other; Protein kinase, Ser/Thr (non-receptor) Q86YV5 157285 8p23.1 human Y413-p 449701 ATQPEPIyAESTKRK carcinogenesis, induced; cell motility, induced; cell adhesion, induced; cytoskeletal reorganization 35740644 2 33 699 -PRKCA PKCA EC 2.7.11.13; KINASE; Kinase, protein; Oncoprotein; Protein kinase, AGC; Protein kinase, Ser/Thr (non-receptor) P04409 282001 cow T497-p 448598 MDGVTTRtFCGTPDY Pkinase enzymatic activity, induced 8042986; 8349635 7 48 62 -SASS6 SAS6 Cell cycle regulation Q6UVJ0 163786 1p21.2 human S510-p 483310 NTIRSGIsPNLNVVD molecular association, regulation; intracellular localization cell cycle regulation NEDD1(DISRUPTS); STIL(DISRUPTS) 36356903 1 13 0 -CALD1 Caldesmon Actin-binding Q05682 800 7q33 human S714-p 456706 EGVRNIKsMWEKGNV Caldesmon cell motility, altered; cytoskeletal reorganization 16800003; 20128924 5 0 0 -JAK2 JAK2 EC 2.7.10.2; KINASE; Kinase, protein; Oncoprotein; Protein kinase, TK; Protein kinase, tyrosine (non-receptor) O60674 3717 9p24.1 human K991-sm 31899101 VENENRVkIGDFGLT PK_Tyr_Ser-Thr molecular association, regulation; intracellular localization GH receptor(DISRUPTS) 23581279 1 0 0 translocation into the nucleus -NR3C1 GR DNA-binding; Mitochondrial; Nuclear receptor; Transcription factor P04150 2908 5q31.3 human S404-p 5044100 SMRPDVSsPPSSSST protein degradation; molecular association, regulation; intracellular localization; protein conformation; activity, inhibited apoptosis, inhibited; transcription, induced FBXW7(INDUCES); NFkB-p65(DISRUPTS); p300(INDUCES) 18838540; 30250038 2 3 1 GR-alpha dimerization in promotes interaction with FBXW7; S404A mutant repressed many genes induced by WT, but overall induced more genes than WT. -EGLN1 EGLN1 EC 1.14.11.29; Oxidoreductase Q9GZT9 54583 1q42.2 human S125-p 7322687 ADPAAAAsPCRAAAG protein degradation; enzymatic activity, induced cell growth, inhibited; apoptosis, induced; transcription, inhibited 28199842; 34339019 3 25 5 HIF1a degradation; induces HIF1 degradation -TOM1L1 Srcasm Adaptor/scaffold O75674 10040 17q22 human Y460-p 451210 AVTTEAIyEEIDAHQ molecular association, regulation; intracellular localization endocytosis, altered GRB2(INDUCES); EGFR(INDUCES) 19798056 4 2 35 regulates EGF-stimulated endocytosis of EGFR -BRAF BRAF EC 2.7.11.1; KINASE; Kinase, protein; Oncoprotein; Protein kinase, Ser/Thr (non-receptor); Protein kinase, TKL P15056 673 7q34 human S429-p 447803 PQRERKSsSSSEDRN enzymatic activity, inhibited transcription, induced; cell growth, altered 10869359; 11293329; 18451171 7 1 32 -GLRA1 GLRA1 Membrane protein, integral; Membrane protein, multi-pass; Transporter; Transporter, ion channel P23415 2741 5q33.1 human S408-p 1869137000 PPPAPSKsPEEMRKL molecular association, regulation; ubiquitination neural plasticity; endocytosis, induced EPS15(INDUCES) 31433808; 32579955 2 1 0 -CDCA8 Borealin Cell cycle regulation; Nucleolus Q53HL2 55143 1p34.3 human T88-p 4203203 QALEEAAtADLDITE cell cycle regulation; cytoskeletal reorganization 18243099 2 0 0 chromosome alignment in mitosis -TPR TPR Membrane protein, peripheral; Nuclear envelope; Nucleoporin; Oncoprotein P12270 7175 1q31.1 human S2108-p 34424908 IQMTRRQsVGRGLQL intracellular localization 24938596 1 3 0 localizes to the nucleolar compartment during mitosis -HNRNPK hnRNP K RNA splicing; RNA-binding; Spliceosome P61978 3190 9q21.32 human T120-p 3193372 QLPSPTAtSQLPLES protein degradation 28423622 1 4 5 -CALD1 Caldesmon Actin-binding P12957 373965 chicken T627-p 15668101 GMKPAHTtAVVSKID Caldesmon molecular association, regulation Caldesmon(DISRUPTS) 20858431 0 1 0 enhances effect of S672 and S702 phosphorylation to weaken interaction -Gphn gephyrin Adaptor/scaffold; EC 2.10.1.1; EC 2.7.7.75 Q8BUV3 268566 12|12 C3 mouse S200-p 478374 LSPPPTTsPHKQTED molecular association, regulation PIN1(INDUCES) 17347650 2 8 0 -CDH5 CDH5 Cell adhesion; Membrane protein, integral; Motility/polarity/chemotaxis P33151 1003 16q21 human Y658-p 456048 GEMDTTSyDVSVLNS molecular association, regulation carcinogenesis, inhibited; cell motility, induced; cell adhesion, induced; transcription, induced; signaling pathway regulation; cell motility, altered; cell adhesion, altered; cytoskeletal reorganization CTNNB1(INDUCES); GPSM2(INDUCES); CTNND1(DISRUPTS) 16027153; 21037229; 25447529; 28712573; 33836597; 36797281 13 0 0 -Mapt Tau ACETYLTRANSFERASE; Acetyltransferase; Cytoskeletal P10637 17762 11 67.79 cM|11 E1 mouse S494-p 447928 SGYSSPGsPGTPGSR molecular association, regulation; intracellular localization; protein conformation; phosphorylation endocytosis, induced; cytoskeletal reorganization Tau(INDUCES) 21445308; 27834631; 31645758; 34220446; 36232909 175 57 116 increase oligomeric Tau secretion -GIT2 GIT2 GAP; GAP, ARF; Motility/polarity/chemotaxis Q14161 9815 12q24.11 human T195-p 38539203 VYGADPGtQDSSGKT Ank_2 molecular association, regulation; intracellular localization DNA repair, induced MDC1(INDUCES); H2AX(INDUCES); NBS1(INDUCES); PARP1(INDUCES) 25605334 1 1 0 nuclear foci formation -Traf3ip2 TRAF3IP2 Apoptosis; UBIQUITIN LIGASE; Ubiquitin conjugating system; Ubiquitin ligase Q8N7N6 103213 10|10 B1 mouse S311-p 21041604 KVILNDSsPQDQEER molecular association, regulation transcription, induced TRAF5(INDUCES); TRAF2(INDUCES); TRAF6(INDUCES) 21822257 1 1 0 -Map3k7 TAK1 EC 2.7.11.25; KINASE; Kinase, protein; Protein kinase, Ser/Thr (non-receptor); Protein kinase, TKL Q62073 26409 4|4 A5 mouse S412-p 455196 NGQPRRRsIQDLTVT activity, induced; enzymatic activity, induced; phosphorylation cell differentiation, altered; transcription, induced; signaling pathway regulation; transcription, altered 15647289; 32108376; 35803916 9 83 63 signaling node linking MAPK and NF-kB pathways, enhances phosphorylation of MAPKs; induces NFKB activity and hence IKK? phosphorylation -Sirt3 SIRT3 DEACETYLASE; Deacetylase; EC 3.5.1.-; Mitochondrial Q8R104 64384 7|7 F4-F5 mouse K57-ac 206219718 GGGSSEKkFSLQDVA protein degradation; acetylation; enzymatic activity, inhibited 28808064 1 1 0 Increased acetylation of LCAD. Impaired fatty acid oxidation -Adrb2 ADRB2 GPCR, family 1; Membrane protein, integral; Membrane protein, multi-pass; Receptor, GPCR P04274 101836719 hamster Y364-p 449810 NSNGKTDyMGEASGC activity, induced 11782469 5 0 0 -Scn2a SCN2A Channel, sodium; Membrane protein, integral; Membrane protein, multi-pass P04775 24766 3q21 rat S687-p 451194 EIRKRRSsSYHVSMD Na_trans_cytopl activity, induced 12359152 3 2 0 -TOP2A TOP2A EC 5.99.1.3; Isomerase P11388 7153 17q21.2 human S1337-p 477804 LDSDEDFsDFDEKTD intracellular localization; enzymatic activity, induced cell cycle regulation; apoptosis, induced 18171681 1 36 11 required for normal sister chromatid segregationi late mitosis -REST REST C2H2-type zinc finger protein; Cell development/differentiation; DNA-binding; Transcription factor Q13127 5978 4q12 human S1027-p 138107500 SDNMSEGsDDSGLHG protein degradation; ubiquitination 29156689 1 0 0 -Eps8 EPS8 Adaptor/scaffold Q08509 13860 6 G1|6 66.78 cM mouse Y497-p 450735 YAYSSSMyHRGPHAD phosphorylation carcinogenesis, induced; cell motility, induced; cell growth, induced; cell adhesion, induced 28214294 1 8 88 enhanced phosphorylation of ERK and FAK, increased cell adhesion and anchorage-dependent colony formation -EIF4G2 EIF4G2 RNA-binding; Translation; Translation initiation P78344 1982 11p15.4 human T508-p 449145 AQPPRTQtPPLGQTP molecular association, regulation translation, induced eIF2-beta(INDUCES) 29530922 1 67 47 during mitosis -VIM Vimentin Cytoskeletal; Motility/polarity/chemotaxis P08670 7431 10p13 human S39-p 451766 TTSTRTYsLGSALRP Filament_head activity, induced; protein degradation; protein stabilization; molecular association, regulation; phosphorylation carcinogenesis, induced; carcinogenesis, inhibited; carcinogenesis, altered; cell motility, induced; cell motility, altered; cytoskeletal reorganization; transcription, altered Vimentin(DISRUPTS) 11895474; 14762106; 19291697; 20856200; 31862882; 33525953 31 52 30 RNF208 targets Ser39 phosphorylation inducing polyubiquitination-mediated degradation, and suppressing metastasis.; Regulates VIF dynamics -Irak1bp1 IRAK1BP1 Transcription regulation Q9ESJ7 65099 9|9 E2 mouse S241-p 12524609 SATIHAAsKVFITFE SIMPL intracellular localization transcription, altered 17079333 1 0 0 nuclear localization -NR1I2 PXR DNA-binding; Nuclear receptor O75469 8856 3q13.33 human S305-p 9730702 TWECGRLsYCLEDTA Hormone_recep molecular association, regulation transcription, altered N-CoR1(INDUCES); FGR(DISRUPTS); RXRA(DISRUPTS) 19617467 2 0 0 inhibits transcription -TBC1D4 AS160 GAP; GAP, Rab O60343 9882 13q22.2 human T568-p 486326 NKAKRSLtSSLENIF molecular association, regulation 14-3-3 epsilon(INDUCES) 20410134 2 13 14 multiple sites (6P) mutant -MSN Moesin Cytoskeletal; Motility/polarity/chemotaxis P26038 4478 Xq12 human T558-p 447706 LGRDKYKtLRQIRQG ERM_C activity, induced; receptor internalization, induced; molecular association, regulation; intracellular localization; activity, inhibited; protein conformation; phosphorylation carcinogenesis, induced; cell motility, induced; cell motility, altered; cytoskeletal reorganization; cell adhesion, inhibited; signaling pathway regulation RhoGDI alpha(INDUCES); MCAM(INDUCES) 19255442; 19395553; 21725352; 21864676; 25799996; 33836044; 34603794; 36100057 40 8 29 -P2rx7 P2X7 Channel, ligand-gated; Membrane protein, integral; Membrane protein, multi-pass; Receptor, misc. Q64663 29665 12q16 rat Y343-p 450310 YIGSTLSyFGLATVC P2X_receptor; TM activity, induced cytoskeletal reorganization 11707406 1 0 0 -GNB1 G-beta 1 G protein; G protein, heterotrimeric; G protein, heterotrimeric beta P62873 2782 1p36.33 human H266-p 9643001 QELMTYShDNIICGI WD40 activity, induced 12486123; 17363702 3 0 0 receptor-independent activation of G proteins regulation of cAMP synthesis and contractility -LRP6 LRP6 Membrane protein, integral; Receptor, misc. O75581 4040 12p13.2 human S1607-p 21241903 HLYPPPPsPCTDSS_ activity, induced; molecular association, regulation signaling pathway regulation axin 1(INDUCES) 21887268 2 1 0 Regulation of Wnt pathway -NCL NCL DNA-binding; Helicase; Nuclear receptor co-regulator; Nucleolus; RNA-binding P19338 4691 2q37.1 human S328-p 31867151 PELKTGIsDVFAKND RRM_1 molecular association, regulation; intracellular localization transcription, induced DROSHA(DISRUPTS) RNA(DISRUPTS) 31182601 1 3 0 miR-93 and miR-484 interactions inhibited, increase KLF2 and eNOS protein expression -Prkce PKCE EC 2.7.11.13; KINASE; Kinase, protein; Protein kinase, AGC; Protein kinase, Ser/Thr (non-receptor) P16054 18754 17|17 E4 mouse S729-p 448789 QEEFKGFsYFGEDLM Pkinase_C intracellular localization; enzymatic activity, induced 11062054; 12640464; 19954762 20 17 7 PLKCE phosphorylated at S729, has Golgi-perinuclear localization and is increased in differetiated C2C12 cells. -Rps6ka1 p90RSK EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, AGC; Protein kinase, Ser/Thr (non-receptor); Translation Q63531 81771 5q36 rat T573-p 447993 AENGLLMtPCYTANF Pkinase activity, induced; phosphorylation; enzymatic activity, induced cell growth, induced; translation, induced 35648763; 9430688 20 16 180 induces eEF2K phosphorylation -Relb RELB Transcription factor Q04863 19698 7 A3|7 9.93 cM mouse S552-p 450233 AFGGGLLsPGPEAT_ RelB_transactiv protein degradation 11781828 2 16 1 -HIPK2 HIPK2 EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, CMGC; Protein kinase, Ser/Thr (non-receptor) Q9H2X6 28996 7q34 human K565-ub 3059906 YDTVNQSkTPFITHV protein degradation 18536714 1 0 0 -GMNN Geminin Cell cycle regulation; Motility/polarity/chemotaxis O75496 51053 6p22.3 human S201-p 475943 CAEGTVSsSTDAKPC apoptosis, altered 17261582 1 0 0 regulates geminin cleavage by caspase-3 -HSP90AA1 HSP90A Chaperone; Heat shock protein P07900 3320 14q32.31 human K327-ac 479815 WEDHLAVkHFSVEGQ HSP90 molecular association, regulation exocytosis, induced CHIP(DISRUPTS); TEBP(DISRUPTS); HSP40(DISRUPTS) 18559531 1 1 2 -RIPK2 RIPK2 EC 2.7.10.2; EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, Ser/Thr (non-receptor); Protein kinase, TKL; Protein kinase, tyrosine (non-receptor) O43353 8767 8q21.3 human Y474-p 4270705 DLIMKEDyELVSTKP CARD protein degradation; molecular association, regulation; ubiquitination; enzymatic activity, induced transcription, induced; signaling pathway regulation NOD1(INDUCES); NOD2(INDUCES) 21123652; 24958724; 31113864; 31350258 5 1 0 influences FCgammaRIII/FcgammaRIIB signaling (ROS production); induces riposome formation, reduces XIAP levels -EEF1A2 EEF1A2 Translation; Translation elongation Q05639 1917 20q13.33 human K55-m2 484742 EMGKGSFkYAWVLDK GTP_EFTU molecular association, regulation L3MBTL iso4(INDUCES) 23583077 0 6 11 -Apobec3 APOBEC3B iso3 EC 3.5.4.-; Hydrolase; RNA-binding Q99J72-3 80287 15 48.6 cM|15 E1 mouse S128-p 31825501 NLSLDIFsSRLYNVQ APOBEC2 enzymatic activity, induced 24453360 1 0 0 -Jak2 JAK2 EC 2.7.10.2; KINASE; Kinase, protein; Oncoprotein; Protein kinase, TK; Protein kinase, tyrosine (non-receptor) Q62120 16452 19 C1|19 23.73 cM mouse Y373-p 20615900 VSLIDGYyRLTADAH Jak1_Phl phosphorylation 21726629 1 1 0 induces autophosphorylation at Y1007 -DLGAP5 DLG7 Cell cycle regulation; Microtubule-binding Q15398 9787 14q22.3 human S725-p 456346 CLSSERMsLPLLAGG molecular association, regulation; intracellular localization TRIP11(INDUCES); GOLGA3(INDUCES); GOLM1(INDUCES); GM130(INDUCES); GRASP65(INDUCES) 37370099 2 15 3 -RAD52 RAD52 DNA repair, damage P43351 5893 12p13.33 human K344-ac 971232909 DAGDGVVkPSSRADP molecular association, regulation; intracellular localization DNA repair, induced RFA2(INDUCES); RPA3(INDUCES); RAD51(INDUCES); RPA1(INDUCES) 29590107 1 1 0 accumulation of RAD52 at DSB sites -PXN PXN Adaptor/scaffold; Cell adhesion; Cytoskeletal; Motility/polarity/chemotaxis P49023 5829 12q24.23 human S274-p 465490 DELMASLsDFKIQGL molecular association, regulation TACE(INDUCES) 23317503 1 4 0 induce lipid raft transfer -NES nestin Cytoskeletal P48681 10763 1q23.1 human T315-p 449820 AENSRLQtPGGGSKT intracellular localization cytoskeletal reorganization 37316833 3 8 1 regulates translocation of cortactin and Pfn-1 -GCM1 GCM1 DNA-binding; Transcription factor Q9NP62 8521 6p12.1 human S269-p 18788303 LYEKRKLsSSRTYSS protein stabilization; molecular association, regulation; acetylation transcription, induced DUSP23(INDUCES) 20855292; 26503785 3 1 0 -RET Ret EC 2.7.10.1; KINASE; Kinase, protein; Membrane protein, integral; Oncoprotein; Protein kinase, TK; Protein kinase, tyrosine (receptor) P07949 5979 10q11.21 human Y905-p 447627 DVYEEDSyVKRSQGR PK_Tyr_Ser-Thr molecular association, regulation; enzymatic activity, induced; phosphorylation cell growth, altered VAV1(INDUCES) 10445857; 11713247; 11956105; 12444552; 14711813; 16928683; 26147533; 28009299; 8637703 17 5 20 -DNMT1 DNMT1 Amino Acid Metabolism - cysteine and methionine; Cell development/differentiation; EC 2.1.1.37; METHYLTRANSFERASE; Methyltransferase; Methyltransferase, DNA; Transcription regulation P26358 1786 19p13.2 human K1415-ac 25171002 ILRDHICkDMSALVA DNA_methylase enzymatic activity, inhibited cell cycle regulation 21947282 1 1 0 -ILF3 NFAT90 DNA-binding; Nucleolus; RNA-binding; Transcription factor Q12906 3609 19p13.2 human T315-p 17734000 RQQREDItQSAQHAL DZF intracellular localization 24920670 3 0 0 cytoplasmic retention, which increases its association with and assembly of large RNA granules -NR1I2 PXR DNA-binding; Nuclear receptor O75469 8856 3q13.33 human Y249-p 27839403 HMADMSTyMFKGIIS Hormone_recep transcription, inhibited 22976785 1 0 0 -RUNX2 AML3 DNA-binding; Transcription factor Q13950 860 6p21.1 human S340-p 4169883 TDVPRRIsDDDTATS transcription, altered 19264160 4 9 0 -HMGB1 HMGB1 DNA repair, damage; Nuclear receptor co-regulator P09429 3146 13q12.3 human K3-ac 459196 _____MGkGDPKKPR molecular association, regulation chromatin organization, altered DNA(INDUCES) 15005629; 18241198 8 1 0 -ETS1 Ets-1 DNA-binding; Motility/polarity/chemotaxis; Oncoprotein; Transcription factor P14921 2113 11q24.3 human S276-p 35524906 SSQSSFNsLQRVPSY Ets1_N_flank protein stabilization; molecular association, regulation COP1(INDUCES) 25117710 1 0 0 -Mark2 MARK2 EC 2.7.11.1; EC 2.7.11.26; KINASE; Kinase, protein; Protein kinase, CAMK; Protein kinase, Ser/Thr (non-receptor) O08679 60328 1q43 rat S212-p 450068 KLDTFCGsPPYAAPE Pkinase enzymatic activity, inhibited; enzymatic activity, induced 14517247; 16257959; 9108484 6 12 11 -YBX1 YB-1 RNA processing; RNA splicing; RNA-binding; Transcription factor P67809 4904 1p34.2 human S176-p 470445 EKNEGSEsAPEGQAQ molecular association, regulation; intracellular localization cell growth, induced; transcription, induced 28077578 2 66 30 anchorage-independent growth, NF-?B DNA binding, nuclear translocation -APEX1 APE1 DNA repair, damage; DNA-binding; Deoxyribonuclease; EC 4.2.99.18; Endoplasmic reticulum; Hydrolase; Lyase; Nuclear receptor co-regulator; Nucleolus; Transcription, coactivator/corepressor P27695 328 14q11.2 human T233-p 14645304 NKKNAGFtPQERQGF Exo_endo_phos activity, induced; protein degradation; ubiquitination transcription, inhibited 21727086 2 0 0 induces gene suppression activity -FOXO3 FOXO3A Autophagy; DNA-binding; Oncoprotein; Transcription factor O43524 2309 6q21 human T179-p 20799901 SSPDKRLtLSQIYEW Forkhead phosphorylation transcription, induced 17711846 2 1 0 induces phosphorylation of other sites -RPN2 RPN2 EC 2.4.99.18; Glycan Metabolism - N-glycan biosynthesis; Membrane protein, integral; Membrane protein, multi-pass; Transferase P04844 6185 20q11.23 human K322-ub 12311757 SRATVLQkTSFTPVG Ribophorin_II protein degradation carcinogenesis, inhibited; cell growth, inhibited 36168628 1 4 23 -PELI1 PELI1 Adaptor/scaffold; EC 6.3.2.-; EC 6.3.2.19; Ligase; UBIQUITIN LIGASE; Ubiquitin conjugating system; Ubiquitin ligase Q96FA3 57162 2p14 human S293-p 7388014 FNTLAFPsMKRKDVV Pellino ubiquitination; enzymatic activity, induced 19264966 2 2 4 -PPP1R12A MYPT1 Motility/polarity/chemotaxis; PHOSPHATASE; Protein phosphatase, regulatory subunit O14974 4659 12q21.2-q21.31 human S445-p 452077 LGLRKTGsYGALAEI molecular association, regulation cell adhesion, altered 14-3-3 beta(INDUCES) 20354225 3 64 80 -ARFIP1 arfaptin 1 G protein regulator, misc. P53367 27236 4q31.3 human S132-p 3191827 LELVRKWsLNTYKCT Arfaptin molecular association, regulation; intracellular localization ARF1(DISRUPTS) 22981988; 25789876 3 32 43 critical for localization of ARFIP1 to Golgi; regulates insulin secretion; regulates retrograde transport -Syk Syk EC 2.7.10.2; KINASE; Kinase, protein; Protein kinase, TK; Protein kinase, tyrosine (non-receptor) P48025 20963 13 A5|13 27.41 cM mouse Y520-p 447662 LRADENYyKAQTHGK PK_Tyr_Ser-Thr enzymatic activity, inhibited; phosphorylation; enzymatic activity, induced transcription, induced 27609517; 33761438; 35196496; 36166754 50 9 72 -Cebpb C/EBP-beta DNA-binding; Motility/polarity/chemotaxis; Transcription factor P28033 12608 2 H3|2 87.58 cM mouse K102-ac 1881371302 YGAKPSKkPADYGYV protein degradation 34642310 1 1 0 SIRT2 decreases acetylation and ubiquitylation (not at K102 site) ; under ethanol stress -CRTC1 TORC1 iso2 Transcription factor Q6UUV9-2 23373 19p13.11 human S167-p 481986 TSWRRTNsDSALHQS TORC_M transcription, inhibited 29408765 7 17 5 -PDX1 PDX1 DNA-binding; Transcription factor P52945 3651 13q12.2 human S61-p 458401 LGALEQGsPPDISPY transcription, induced 12810726 3 1 0 -Rps6kb2 P70S6KB EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, AGC; Protein kinase, Ser/Thr (non-receptor); Translation Q9Z1M4 58988 19|19 A mouse S417-p 455990 SPRRLNSsPRTPISP phosphorylation 17980619 2 10 11 -GYS1 GYS1 Carbohydrate Metabolism - starch and sucrose; EC 2.4.1.11; Transferase P13807 2997 19q13.33 human S11-p 451605 NRTLSMSsLPGLEDW enzymatic activity, inhibited 19339242; 35793618 10 2 1 -RPA2 RFA2 DNA replication P15927 6118 1p35.3 human T21-p 448340 YGGAGGYtQSPGGFG molecular association, regulation; intracellular localization; phosphorylation cell cycle regulation; DNA repair, induced; apoptosis, altered; carcinogenesis, inhibited; transcription, altered; cell growth, altered p53(INDUCES); WRN(INDUCES) 17035231; 19704001; 19843584; 21107010; 29875999; 32989256; 35078814 21 0 0 -Prkd1 PRKD1 Autophagy; EC 2.7.11.13; KINASE; Kinase, protein; Motility/polarity/chemotaxis; Protein kinase, CAMK; Protein kinase, Ser/Thr (non-receptor) Q62101 18760 12|12 B3 mouse S203-p 449896 GVRRRRLsNVSLTGL enzymatic activity, induced 9765302 8 36 86 -APBB1 Fe65 Adaptor/scaffold; Apoptosis; Transcription regulation O00213 322 11p15.4 human Y547-p 451143 VQKFQVYyLGNVPVA PID molecular association, regulation transcription, induced RASD1(DISRUPTS) 18922798 2 1 0 part of a tripartite complex with APP -Dpysl2 CRMP-2 Microtubule-binding; Motility/polarity/chemotaxis P47942 25416 15p12 rat Y32-p 463168 VNDDQSFyADIYMED molecular association, regulation SCN9A(DISRUPTS) 27940916 3 4 62 -H2AX H2AX DNA repair, damage; DNA-binding; Helicase P16104 3014 11q23.3 human S139-p 448841 GKKATQAsQEY____ acetylation; molecular association, regulation; intracellular localization cell differentiation, inhibited; cell cycle regulation; apoptosis, altered; carcinogenesis, inhibited; apoptosis, induced; transcription, induced; transcription, altered; DNA repair, induced; DNA repair, altered; cytoskeletal reorganization Tip60(INDUCES); SMARCA2(INDUCES); PARP1(INDUCES); 53BP1(INDUCES); GCN5(INDUCES); MDC1(INDUCES); TEAD3(INDUCES); NBS1(INDUCES); H1B(DISRUPTS); SMARCA4(INDUCES); 53BP1(NOT_REPORTED); RAD50(INDUCES) 12607005; 12697768; 16377563; 18406329; 18758438; 18987440; 19305155; 20224553; 20356835; 20488183; 20637859; 20703100; 20921231; 22037398; 25487737; 26628370; 33512436; 33691101; 33731502; 33857133; 33986864; 34429760; 34711990; 34716195; 36060800; 36640924 289 32 29 -CTNNB1 CTNNB1 Actin-binding; Cell adhesion; Motility/polarity/chemotaxis; Nuclear receptor co-regulator; Oncoprotein; Transcription factor P35222 1499 3p22.1 human S184-p 1881579404 QLSKKEAsRHAIMRS protein stabilization; molecular association, regulation; intracellular localization; phosphorylation carcinogenesis, induced; transcription, induced; signaling pathway regulation GSK3B(DISRUPTS); BTRC(DISRUPTS); CK1A(DISRUPTS) 36808719 1 1 0 inhibits phosphorylation at Thr41 and Ser45 and ubiquitination, induces ?-catenin downstream signaling -PGAM1 PGAM1 Carbohydrate Metabolism - glycolysis and gluconeogenesis; EC 3.1.3.13; EC 5.4.2.11; EC 5.4.2.4; Isomerase; Phosphatase (non-protein) P18669 5223 10q24.1 human S118-p 455497 QVKIWRRsYDVPPPP His_Phos_1 enzymatic activity, inhibited 12189148 1 43 5 -PTPN5 STEP EC 3.1.3.48; Membrane protein, multi-pass; Motility/polarity/chemotaxis; PHOSPHATASE; Protein phosphatase, tyrosine (non-receptor) P54829 84867 11p15.1 human S268-p 20745211 EGFGYLMsPREESAR protein stabilization 21777200 1 0 0 -Kcnq3 Kv7.3 iso2 Channel, potassium; Membrane protein, integral; Membrane protein, multi-pass O88944-2 29682 7q34 rat Y349-p 453409 IQAAWRYyATNPNRL activity, inhibited 15304482 1 0 0 inhibition of K(+) current via reducing open probability. -MAD1L1 MAD1L1 Cell cycle regulation; Cytoskeletal Q9Y6D9 8379 7p22.3 human T716-p 334535800 LELFSRQtVA_____ MAD molecular association, regulation cell cycle regulation Mad2(INDUCES) 29162720; 32202322 2 0 0 -RAPGEF2 RAPGEF2 GEF; GEF, Ras; Motility/polarity/chemotaxis Q9Y4G8 9693 4q32.1 human S960-p 1245534 KKRVRRSsFLNAKKL activity, induced cell adhesion, altered 18796635 1 26 121 Rap1 activation -DEPTOR DEPTOR Apoptosis Q8TB45 64798 8q24.12 human S265-p 4723818 STSFMSVsPSKEIKI protein degradation; molecular association, regulation carcinogenesis, induced; apoptosis, inhibited; signaling pathway regulation mTOR(DISRUPTS) 19446321 2 23 0 PI3K-Akt signaling -Tfeb TFEB DNA-binding; Transcription factor Q9R210 21425 17 C|17 23.99 cM mouse S468-p 4785147 SSRRSSFsMEEGDVL DUF3371 protein stabilization transcription, induced 23599343 1 13 0 -RRAGA RRAGA G protein regulator, misc. Q7L523 10670 9p22.1 human K220-ub 15497049 VISHYQCkEQRDVHR Gtr1_RagA molecular association, regulation; phosphorylation autophagy, induced; signaling pathway regulation NPRL3(INDUCES); Raptor(DISRUPTS); DEPDC5(INDUCES); NPRL2(INDUCES) 25936802 1 1 1 interaction with GATOR1 complex, regulates mTORC1 signaling, regulates p70S6K phosphorylation -Stat6 STAT6 DNA-binding; Transcription factor P52633 20852 10 D3|10 74.59 cM mouse K383-ac 1880010904 TESVTEEkCAVLFST transcription, inhibited DNA(DISRUPTS) 31554795 1 1 0 Trim24-mediated Stat6 K383 acetylation disrupts Stat6?DNA association and inhibits M2 macrophage M2 polarization. -Tnk2 Ack EC 2.7.10.2; EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, TK; Protein kinase, tyrosine (non-receptor) O54967 51789 16|16 B3 mouse Y284-p 450946 LPQNDDHyVMQEHRK PK_Tyr_Ser-Thr enzymatic activity, induced carcinogenesis, induced 36376335 14 28 235 -PKM PKM Carbohydrate Metabolism - glycolysis and gluconeogenesis; Carbohydrate Metabolism - pyruvate; EC 2.7.1.40; KINASE; Kinase, other; Mitochondrial; Nucleotide Metabolism - purine P14618 5315 15q23 human K433-ac 11318768 GAIIVLTkSGRSAHQ PK_C molecular association, regulation; intracellular localization; enzymatic activity, inhibited; enzymatic activity, altered; enzymatic activity, induced; phosphorylation carcinogenesis, induced; apoptosis, induced; cell motility, induced; cell growth, induced; transcription, induced; signaling pathway regulation; transcription, altered PKM iso2(DISRUPTS); PKM(DISRUPTS); DDB2(INDUCES); Exportin-4(DISRUPTS); CTNNB1(INDUCES) Other(INDUCES); Other(DISRUPTS) 24120661; 26410533; 26787900; 32460017; 32989054; 34016961; 35821123 8 4 1 K433 acetylation inhibits PKM pyruvate kinase activity and promoting aerobic glycolysis; enzymatic activity decreases as the pH is increased from 7.0 to 8.0 ; PCB2 activates SIRT3 deacetylates K433 PKM2 inducing an antiapoptotic effect reducing lung I/R injury.; required for tumor growth ; interaction with fructose 1, 6-bisphosphate, causing a disruption in PKM oligomerization, dimeric PKM translocate into the nucleus -GATA1 GATA1 DNA-binding; Transcription factor P17678 396450 chicken K218-ac 459079 RNRKVSSkGKKRRPP molecular association, regulation; protein conformation cell differentiation, induced; transcription, induced DNA(INDUCES) 9859997 6 1 0 -CCND1 CCND1 Activator; Cell cycle regulation; Nuclear receptor co-regulator; Oncoprotein P24385 595 11q13.3 human K269-ub 12159005 AQQNMDPkAAEEEEE Cyclin_C protein degradation; molecular association, regulation; intracellular localization cell growth, inhibited PSMD7(INDUCES) 19767775 1 0 0 -NEDD9 Cas-L Adaptor/scaffold; Motility/polarity/chemotaxis Q14511 4739 6p24.2 human Y12-p 452009 NLMARALyDNVPECA SH3_9 molecular association, regulation cytoskeletal reorganization Src(INDUCES); FAK(INDUCES) 29876004 1 1 3 MMP9 secretion and invadopodia formation requires Y12 phosphorylation and SH3 domain. -PARD3B PAR3-beta Adaptor/scaffold; Motility/polarity/chemotaxis Q8TEW8 117583 2q33.3 human S746-p 455652 LGLKKSSsLESLQTA molecular association, regulation 14-3-3 zeta(INDUCES) 15721295 1 25 0 -GYS1 GYS1 Carbohydrate Metabolism - starch and sucrose; EC 2.4.1.11; Transferase P13807 2997 19q13.33 human S727-p 457615 STPSEPLsPTSSLGE phosphorylation 34758018 2 20 3 primes phopshorylation at S641 -Nkx2-5 NKX2-5 DNA-binding P42582 18091 17 A3.3|17 13.6 cM mouse K51-sm 25344500 SCMLAAFkPEAYSGP cell growth, induced; transcription, altered 21677783 1 0 0 -CARD9 CARD9 Adaptor/scaffold Q9H257 64170 9q34.3 human T533-p 1206000 TGSDNTDtEGS____ activity, inhibited 17936701 1 1 0 impairs ability of CARD9 to activate NF-kB -NEDD4 NEDD4 iso4 EC 6.3.2.-; EC 6.3.2.19; Ligase; Nuclear receptor co-regulator; UBIQUITIN LIGASE; Ubiquitin conjugating system; Ubiquitin ligase P46934-4 4734 15q21.3 human Y585-p 4155214 DGEKGLDyGGVAREW protein conformation; enzymatic activity, induced endocytosis, induced; cell growth, induced; signaling pathway regulation 25292214 1 1 3 -Map2 MAP2 Cytoskeletal; Motility/polarity/chemotaxis P15146 25595 9q32 rat T1619-p 4704347 PPSYSSRtPGTPGTP molecular association, regulation cytoskeletal reorganization 25309320 1 10 7 fractionated with microtubules, protrusion growth, regulates basal dendrite architecture in vivo -Arhgdia RhoGDI alpha Apoptosis; Cell adhesion; Cell development/differentiation; G protein regulator, misc.; Motility/polarity/chemotaxis Q99PT1 192662 11|11 E2 mouse S101-p 452195 LESFKKQsFVLKEGV Rho_GDI intracellular localization; enzymatic activity, induced 37364105 6 11 1 induces Rac1 activity and GLUT4 translocation -MORC2 MORC2 DNA-binding Q9Y6X9 22880 22q12.2 human T582-p 30982293 LEALQKTtPIRSQAD protein stabilization; molecular association, regulation carcinogenesis, induced HSC70(DISRUPTS) 32401166 1 1 0 -KCNJ13 KCNJ13 Channel, potassium; Membrane protein, integral; Membrane protein, multi-pass O60928 3769 2q37.1 human S287-p 6039503 EICQRRTsYLPSEIM IRK_C activity, induced 18976636 1 0 0 -Bub1b BUB1B EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, Other; Protein kinase, Ser/Thr (non-receptor); Tumor suppressor Q9Z1S0 12236 2|2 E5 mouse K243-ac 7761217 SRVGGALkAPGQSRG molecular association, regulation cell cycle regulation; carcinogenesis, inhibited; cytoskeletal reorganization 23878276; 25559578 5 1 0 checkpoint maintenance, chromosome-spindle attachment; acetylation site necessary for embryonic development, spontaneous tumorigenesis in K243R/+ mutant mice, mutant shows: aneuploidy and premature sister chromatid separations, weakened spindle assembly checkpoint, defects in kinetochore-microtubule attachments acetylation of at BubR1 is required for recruiting PP2A-B56-alpha phosphatase to kinetochore -E2F4 E2F4 DNA-binding E1BUH4 chicken T261-p 25571901 PSSTQPStPTPSSTQ cell cycle regulation; apoptosis, induced 22586272 1 0 0 -Atg5 ATG5 Apoptosis; Autophagy; Ubiquitin conjugating system Q99J83 11793 10 B2|10 23.24 cM mouse K118-ub 1883300102 DLLHCPSkDAVEAHF protein degradation; ubiquitination autophagy, induced 35900990 1 0 0 USP22 promotes the degradation of NLRP3 via ATG5-mediated autophagy -SNCAIP SNCAIP Vesicle Q9Y6H5 9627 5q23.2 human S556-p 469990 AQKSEGKsLPSSPSS SNCAIP_SNCA_bd protein stabilization; molecular association, regulation; protein processing 14-3-3 beta(INDUCES) 16174773 1 1 3 14-3-3 enhances phosphorylation of SNCIAP by GSK3B. Inhibition of GSK3B increases formation of SNCIAP cytoplasmic inclusion bodies. -KIF4A KIF4A Microtubule-binding; Motor O95239 24137 Xq13.1 human T1161-p 459852 FFNPVCAtPNSKILK intracellular localization cell cycle regulation 29771379 1 7 0 regulates its chromosomal localization in early mitosis; critical for the functions of Kif4A required for early mitotic progression -H3C1 H3 DNA-binding P68431 8350 6p22.2 human T6-p 13321500 __ARTKQtARKSTGG Histone molecular association, regulation; methylation apoptosis, inhibited; transcription, induced PHF21A(DISRUPTS); ING2(DISRUPTS); RAG2(DISRUPTS); AIRE(DISRUPTS) 20190764; 20228790; 25482560; 25553095 5 2 0 high phosphorylation levels associated with a phenotype of resistance to TMZ+Irrad-induced cell death -BLM BLM DNA repair, damage; DNA replication; EC 3.6.4.12; Helicase P54132 641 15q26.1 human K225-ub 28132101 IDLTEEQkDDSEWLS BLM_N molecular association, regulation; intracellular localization DNA repair, inhibited RAP80(INDUCES) 23708797 1 0 0 -SEPTIN4 SEPT4 Apoptosis; Cell development/differentiation; Cytoskeletal; Hydrolase O43236 5414 17q22 human K174-ub 27208422 TDLYRDRkLLGAEER Septin protein degradation; ubiquitination 31924572 1 1 0 -Acadl ACADL EC 1.3.8.8; Lipid Metabolism - fatty acid; Mitochondrial; Oxidoreductase P51174 11363 1 C3|1 33.64 cM mouse K322-ac 1204119 KQRKAFGkTVAHIQT Acyl-CoA_dh_1 protein conformation; enzymatic activity, induced 24121500 1 3 1 -PCK1 PCK1 Carbohydrate Metabolism - citrate (TCA) cycle; Carbohydrate Metabolism - glycolysis and gluconeogenesis; Carbohydrate Metabolism - pyruvate; EC 4.1.1.32; KINASE; Kinase, other; Lyase; Protein kinase, Ser/Thr (non-receptor) P35558 5105 20q13.31 human K244-ac 1877232013 GNSLLGKkCFALRMA PEPCK_N enzymatic activity, inhibited 33334880 0 1 0 -CDCA5 CDCA5 Cell cycle regulation Q96FF9 113130 11q13.1 human S164-p 9316471 TSTPGRRsCFGFEGL Sororin activity, inhibited cell cycle regulation SCC-112(DISRUPTS) 23901111 1 4 1 -H3C14 HIST2H3A/C/D DNA-binding Q71DI3 126961 1q21.2 human R8-m2 18465154 ARTKQTArKSTGGKA Histone chromatin organization, altered; transcription, induced 20075197 1 0 0 -Akt2 Akt2 EC 2.7.11.1; KINASE; Kinase, protein; Oncoprotein; Protein kinase, AGC; Protein kinase, Ser/Thr (non-receptor) P47197 25233 1q21 rat S474-p 448520 RTHFPQFsYSASIRE Pkinase_C activity, induced 22846604 37 9 55 Glucose uptake in skeletal muscles -ZMYM2 ZNF198 Transcription factor Q9UBW7 7750 13q12.11 human S305-p 483897 QPGVDSLsPVASLPK molecular association, regulation; ubiquitination HDAC1(DISRUPTS); LSD1(DISRUPTS) 25855382 1 34 3 -CLEC1B CLEC1B Membrane protein, integral; Receptor, misc. Q9P126 51266 12p13.31-p13.2 human Y7-p 13244602 _MQDEDGyITLNIKT molecular association, regulation; activity, inhibited Syk(INDUCES) 20154219 1 0 0 Clec1b Y7F mutant has an inhibitory effect on signaling by wt Clec1b -APH1A APH1A Apoptosis; Endoplasmic reticulum; Membrane protein, integral; Membrane protein, multi-pass Q96BI3 51107 1q21.2 human S110-p 1877641904 SLSEDGRsPISIRQM Aph-1 molecular association, regulation; enzymatic activity, altered ARRB2(INDUCES) 35858570 1 1 0 -SOX10 SOX10 Cell development/differentiation; DNA-binding; Transcription factor P56693 6663 22q13.1 human K246-sm 3875803 PTPPTTPkTELQSGK molecular association, regulation transcription, inhibited EGR2(DISRUPTS); PAX3(DISRUPTS) 16494873 1 0 0 -Pdzrn3 PDZRN3 EC 6.3.2.-; Ligase; UBIQUITIN LIGASE; Ubiquitin conjugating system; Ubiquitin ligase Q69ZS0 55983 6|6 D3 mouse T956-p 25304558 EERSGLTtDDDAMSE protein degradation cell motility, inhibited 34135125 1 4 2 -H3C1 H3 DNA-binding P68431 8350 6p22.2 human R8-me 62566200 ARTKQTArKSTGGKA Histone acetylation 15485929 1 0 0 -WNK4 WNK4 EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, Other; Protein kinase, Ser/Thr (non-receptor) Q96J92 65266 17q21.2 human S1201-p 23073728 FPTSRRNsLQRSEPP activity, induced; phosphorylation 23054253 2 1 1 decrease phosphorylation of S1217; regulates NKCC2 activity -Il7r IL7R Membrane protein, integral; Receptor, cytokine P16872 16197 15 A1|15 4.16 cM mouse Y449-p 451291 VLNQEEAyVTMSSFY phosphorylation translation, altered; cell growth, induced; cell differentiation, induced; apoptosis, inhibited; transcription, induced; signaling pathway regulation; transcription, altered 15226449; 17602185; 25143441; 31924648; 35021100 7 0 0 induces STAT5 phosphorylation; PI3K/STAT5 signaling, Regulates TCF1 expression and T cell development; induce phosphorylation of STAT5 and Akt, regulates STAT5 and PI3/Akt pathways; Proteomics analysis of WT and Y449F IL7R shows that various proteins are effected (both upregulated and downregulated differences). Not specified whether they are transcriptional or translational effects. For example, GIMAP4, Annexin A6, STAT1, CDC42 were downregulated. BIT1 and FKBP51 were upregulated in the mutant. -NFKB2 NFkB-p100 DNA-binding; Oncoprotein; Transcription factor Q00653 4791 10q24.32 human K689-sm 3055609 TLTRLLLkAGADIHA Ank_2 protein processing; phosphorylation signaling pathway regulation 18617892 1 0 0 activation of alternative NF-kB pathway -PPP1R12B PPP1R12B Activator; Motility/polarity/chemotaxis; Protein phosphatase, regulatory subunit O60237 4660 1q32.1 human T646-p 478177 ARQTRRStQGVTLTD activity, inhibited 16431080 1 16 78 inhibits phosphatase activity of PP1c-delta -TERT TERT DNA-binding; EC 2.7.7.49; Nucleolus; Transferase O14746 7015 5p15.33 human S227-p 11418800 GARRRGGsASRSLPL intracellular localization; enzymatic activity, induced apoptosis, inhibited; cytoskeletal reorganization KPNA1(INDUCES); KPNA5(INDUCES); KPNB1(INDUCES) 10224060; 22366458; 25999477 3 0 0 facilitates nuclear import of TERT; nuclear import -ETFB ETFB Mitochondrial; Oxidoreductase P38117 2109 19q13.41 human K200-m3 15381912 ATLPNIMkAKKKKIE ETF enzymatic activity, inhibited 25416781 2 2 1 inhibitory effect on the transfer of electrons -MAPK6 ERK3 EC 2.7.11.24; KINASE; Kinase, protein; Protein kinase, CMGC; Protein kinase, Ser/Thr (non-receptor) Q16659 5597 15q21.2 human S705-p 13830501 TPSAMKSsPQIPHQT protein stabilization 20236090 1 2 0 -ACTL6A BAF53A O96019 86 3q26.33 human S195-p 1876807200 LQQGIVKsPLAGDFI Actin molecular association, regulation apoptosis, induced; transcription, induced RASSF6(INDUCES) 34898277 1 0 0 -Foxk2 FOXK2 DNA-binding; Transcription factor Q3UCQ1 68837 11|11 E2 mouse S200-p 1876808206 GTISAANsCPSSPRG intracellular localization carcinogenesis, induced; transcription, altered 35412849 1 1 0 -PBK PBK Cancer Testis Antigen (CTA); EC 2.7.12.2; KINASE; Kinase, protein; Protein kinase, Other; Protein kinase, Ser/Thr (non-receptor); Protein kinase, dual-specificity (non-receptor) Q96KB5 55872 8p21.1 human T9-p 451735 EGISNFKtPSKLSEK molecular association, regulation; phosphorylation; enzymatic activity, induced carcinogenesis, induced; cytoskeletal reorganization; signaling pathway regulation CCNB1(INDUCES); TUBA4A(INDUCES); CDK1(INDUCES) 15541388; 16291951; 29904102 6 12 2 induces phosphorylation of PRPK, regulates Pbk/PRPK pathway -RPL11 RPL11 Motility/polarity/chemotaxis; Nucleolus; Ribosomal; Translation P62913 6135 1p36.11 human K145-ne 12067615 GFSIADKkRRTGCIG Ribosomal_L5_C protein stabilization; intracellular localization 19713960 1 0 0 -SQSTM1 SQSTM1 Autophagy; Nuclear receptor co-regulator; Ubiquitin conjugating system Q13501 8878 5q35.3 human K435-ub 4953938 LDTIQYSkHPPPL__ UBA_5 intracellular localization signaling pathway regulation 33472082 1 12 94 recruitment of vesicle adaptors to RNF26, inhibition of EGF-induced AKT signaling -CHEK2 Chk2 EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, CAMK; Protein kinase, Ser/Thr (non-receptor); Tumor suppressor O96017 11200 22q12.1 human T387-p 447552 LMRTLCGtPTYLAPE Pkinase intracellular localization; protein conformation; enzymatic activity, induced cell cycle regulation 11390408; 12805407; 15361830; 16794575; 17698850; 20713355 18 5 0 -BANP BANP Tumor suppressor Q8N9N5 54971 16q24.2 human T352-p 41301701 PSEPMMStPPPASEL intracellular localization 26080397 1 0 0 cytoplasmic localization -PKM PKM Carbohydrate Metabolism - glycolysis and gluconeogenesis; Carbohydrate Metabolism - pyruvate; EC 2.7.1.40; KINASE; Kinase, other; Mitochondrial; Nucleotide Metabolism - purine P14618 5315 15q23 human T129-p 27110042 GLIKGSGtAEVELKK PK molecular association, regulation; phosphorylation PKM(DISRUPTS) 32054489 1 8 0 blocks the conversion of tetramer to dimer; PKM dimerization inhibited; inhibits STAT3 phosphorylation -SLC25A4 SLC25A4 Membrane protein, integral; Membrane protein, multi-pass; Mitochondrial; Transporter; Transporter, SLC family P12235 291 4q35.1 human Y191-p 462625 IIIYRAAyFGVYDTA Mito_carr; TM cell growth, altered 20007455 1 13 344 required for an efficient oxidative growth in yeast -KIF23 KIF23 Microtubule-binding; Motility/polarity/chemotaxis; Motor Q02241 9493 15q23 human S716-p 453934 QLHRRSNsCSSISVA molecular association, regulation; intracellular localization LIMK1(INDUCES) 25786116 2 4 0 activation of LIMK1 on centrosomes; localizes to the centrosome during mitosis, required for cytokinesis -DTD1 DTD1 DNA replication; EC 3.1.-.-; Hydrolase Q8TEA8 92675 20p11.23 human S205-p 485755 GAEGDVSsEREP___ molecular association, regulation cell cycle regulation; cell growth, induced MCM7(INDUCES); MCM3(DISRUPTS) 25258324 1 41 5 decreases DTD1 incorporation into HMW, supports DNA replication initiation -NHEJ1 NHEJ1 DNA repair, damage Q9H9Q4 79840 2q35 human T181-p 35499302 LIRDRLKtEPFEENS protein degradation; molecular association, regulation; ubiquitination; intracellular localization 14-3-3 beta(INDUCES); XRCC4(DISRUPTS) 25661488 1 1 0 interaction with 14-3-3-beta, for cytoplasmic retention of XLF, phosphorylation impairs NHEJ and V(D)J recombination -PTEN PTEN Carbohydrate Metabolism - inositol phosphate; EC 3.1.3.16; EC 3.1.3.48; EC 3.1.3.67; Motility/polarity/chemotaxis; Nuclear receptor co-regulator; PHOSPHATASE; Phosphatase, lipid; Tumor suppressor P60484 5728 10q23.31 human Y68-p 7331394 HKNHYKIyNLCAERH protein stabilization 22891331 2 1 0 -Stat3 STAT3 DNA-binding; Motility/polarity/chemotaxis; Nuclear receptor co-regulator; Transcription factor P42227 20848 11 D|11 63.82 cM mouse S754-p 35494901 SAGGQFEsLTFDMDL transcription, inhibited 28188292 3 0 0 -APC APC Motility/polarity/chemotaxis; Tumor suppressor P25054 324 5q22.2 human S2793-p 10211300 YNPSPRKsSADSTSA EB1_binding molecular association, regulation EB1(DISRUPTS) 19632184 1 0 0 -C2CD5 CDP138 Vesicle Q86YS7 9847 12p12.1 human S197-p 21398500 EARQRLIsLMSGELQ molecular association, regulation; intracellular localization exocytosis, induced; signaling pathway regulation GLUT4(INDUCES) 21907143 1 1 0 GLUT4 translocation induced and regulates Akt2 signaling pathway -LAMP2 LAMP2 Membrane protein, integral P13473 3920 Xq24 human T211-p 386186605 TVPSPTTtPTPKEKP protein degradation; intracellular localization; protein conformation carcinogenesis, induced; autophagy, induced; cell growth, induced 29176575; 33685990 2 0 0 -NFKBIA IkB-alpha DNA-binding; Inhibitor P25963 4792 14q13.2 human K21-ub 485773 EGPRDGLkKERLLDD activity, induced; protein degradation; ubiquitination; intracellular localization transcription, induced 7479976; 8550590; 8649784; 9724653; 9990853 9 0 0 -SNAI2 Snail2 Apoptosis; C2H2-type zinc finger protein; Motility/polarity/chemotaxis; Transcription factor O43623 6591 8q11.21 human S92-p 25603910 RVSPPPPsDTSSKDH protein degradation; intracellular localization cell motility, inhibited; transcription, induced CHIP(INDUCES) 22727060; 23851495 2 1 0 WT localizes in cytosol and nucleus; transcriptional activity of E-cadherin; Snail2 luciferase construct, may affect lung metastasis in NSCLC.; mutants enhance epithelial-mesenchymal transition (EMT) -Mfn2 MFN2 Cell cycle regulation; Cytoskeletal; EC 3.6.5.-; Hydrolase; Membrane protein, integral; Membrane protein, multi-pass; Mitochondrial Q80U63 170731 4|4 E2 mouse T111-p 17402150 RTSNGKStVINAMLW Dynamin_N cell differentiation, inhibited; autophagy, induced 32165499 3 1 0 induces mitophagy -SRC Src EC 2.7.10.2; KINASE; Kinase, protein; Oncoprotein; Protein kinase, TK; Protein kinase, tyrosine (non-receptor) P00523 396442 chicken Y416-p 448234 RLIEDNEyTARQGAK PK_Tyr_Ser-Thr phosphorylation; enzymatic activity, induced neural plasticity; cell motility, altered; cytoskeletal reorganization; cell adhesion, altered; cell growth, altered 11909938; 14593208; 16024778; 2474754; 2582236; 27881656; 3103925; 3103926; 34616310 447 103 3046 -Zfp110 ZNF274 C2H2-type zinc finger protein; DNA-binding; Nucleolus; Transcription factor Q923B3 65020 7 A1|7 7.66 cM mouse K15-ub 1872271902 TWPHESVkFEDVSLT KRAB intracellular localization apoptosis, induced 16252010 1 0 0 nuclear localization -GEMIN5 GEMIN5 Nuclear receptor co-regulator; RNA processing; RNA splicing; RNA-binding Q8TEQ6 25929 5q33.2 human T897-p 83111227 RFHLGLFtDRATLYR molecular association, regulation; protein conformation translation, induced G3BP-2(INDUCES); ELF4(INDUCES); FMR1(INDUCES); AGO2(INDUCES); IGF2BP2(INDUCES); IGF2BP3(INDUCES) 36420152 1 1 0 -APC APC Motility/polarity/chemotaxis; Tumor suppressor P25054 324 5q22.2 human S1392-p 450135 SRCTSVSsLDSFESR APC_r transcription, altered 11487578 2 3 0 -Kcnj1 ROMK Channel, potassium; Membrane protein, integral; Membrane protein, multi-pass P35560 24521 8q21 rat S313-p 2461200 ATCQVRTsYVPEEVL IRK_C activity, induced; protein conformation 18311184 5 0 0 -BTLA BTLA Membrane protein, integral Q7Z6A9 151888 3q13.2 human Y243-p 1869334003 MQEGSEVySNPCLEE phosphorylation signaling pathway regulation 32437509 1 0 0 inhibits IL2 production, phosphorylation of CD3Z and CD28, and hence T cell signaling -PLAGL2 PLAGL2 C2H2-type zinc finger protein; DNA-binding Q9UPG8 5326 20q11.21 human K356-sm 483051 YLPDKLPkVEVDSFL intracellular localization cell growth, induced; transcription, inhibited 16207715 3 0 0 -Olig2 OLIG2 Oncoprotein; Transcription factor Q9EQW6 50913 16 C3.3|16 52.6 cM mouse K76-sm 1869334000 KLGGGGFkSSSSSTS molecular association, regulation cell cycle regulation; carcinogenesis, induced; apoptosis, inhibited; DNA repair, inhibited; transcription, inhibited HDAC1(INDUCES) DNA(INDUCES) 32483381 1 1 0 -DOCK8 DOCK8 GEF; GEF, misc.; Motility/polarity/chemotaxis Q8NF50 81704 9p24.3 human S2077-p 3929061 KPIFRVEsQKRDSFH molecular association, regulation cell motility, induced LRCH1(DISRUPTS) 28028151 1 8 17 -Ybx1 YB-1 RNA processing; RNA splicing; RNA-binding; Transcription factor P62960 22608 4|4 D2.1 mouse Y97-p 15416754 KKNNPRKyLRSVGDG CSD carcinogenesis, induced; translation, induced 36044842 2 2 3 -STT3A Chk1 EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, CAMK; Protein kinase, Ser/Thr (non-receptor); Tumor suppressor Q8AYC9 374260 chicken S301-p 465528 IRSDTDFsPVKSALG enzymatic activity, induced cell cycle regulation 21765472 5 22 5 -Robo3 ROBO3 Membrane protein, integral Q9Z2I4 19649 9|9 A4 mouse Y1019-p 37043702 ASGEGPVySTIDPVG cell motility, induced 25433640 1 0 0 mediating Robo3 attraction -TYMS TYMS Cofactor and Vitamin Metabolism - one carbon pool by folate; DNA repair, damage; EC 2.1.1.45; METHYLTRANSFERASE; Methyltransferase; Mitochondrial; Nucleotide Metabolism - pyrimidine P04818 7298 18p11.32 human T251-gl 1875343302 KPGDFIHtLGDAHIY Thymidylat_synt protein stabilization TYMS(INDUCES) 34845374 1 1 0 dimer stabilization by intra- and inter-monomer interactions -PDCD4 PDCD4 Apoptosis; Tumor suppressor Q53EL6 27250 10q25.2 human S71-p 1211014 RKNSSRDsGRGDSVS protein degradation; molecular association, regulation cell cycle regulation; translation, altered; cell growth, altered BTRC(INDUCES) 17053147 1 16 21 -Myod1 MyoD DNA-binding; RNA splicing; Transcription factor P10085 17927 7 B3|7 30.03 cM mouse Y30-p 449872 FETADDFyDDPCFDS Basic molecular association, regulation; activity, inhibited DNA repair, induced NBS1(INDUCES) DNA(INDUCES) 12415271; 24056763 3 0 0 -RBL2 Rb-like 2 Transcription, coactivator/corepressor; Tumor suppressor Q08999 5934 16q12.2 human S1112-p 449743 LLEDGSEsPAKRICP molecular association, regulation cell cycle regulation E2F4(DISRUPTS) 11157749; 12006580 3 20 1 -PDE4A PDE4A iso2 EC 3.1.4.53; Nucleotide Metabolism - purine; Phosphodiesterase P27815-2 5141 19p13.2 human S119-p 458389 ATSQRREsFLYRSDS enzymatic activity, induced 15738310 4 20 1 -Prkab1 AMPKB1 Autophagy; KINASE; Protein kinase, regulatory subunit Q9R078 19079 5|5 F mouse S108-p 448522 SKLPLTRsQNNFVAI AMPK1_CBM phosphorylation; enzymatic activity, induced autophagy, induced; signaling pathway regulation 33658485; 36409897 11 64 2 induces ACC phosphorylation; induces AMPK pathway, reduces lipid deposition -STK38 NDR1 EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, AGC; Protein kinase, Ser/Thr (non-receptor) Q15208 11329 6p21.31 human S281-p 448828 NRRQLAFsTVGTPDY Pkinase activity, induced; molecular association, regulation; intracellular localization; phosphorylation; enzymatic activity, induced cytoskeletal reorganization; signaling pathway regulation MOBP(INDUCES); CCND1(INDUCES) 12493777; 16135814; 22445341; 23897809; 31679687 6 2 15 reduction in dendritic branching and length ; in glucose starvation -Ifi204 IFI16 Transcription factor P0DOV2 15951 1 H3|1 80.63 cM mouse R12-me 1877257500 YKRIVLLrGLECINK PYRIN signaling pathway regulation 32641491 1 0 0 dsDNA-stimulated STING pathway activation -RIN1 Rin1 GEF; GEF, Rab Q13671 9610 11q13.2 human S292-p 4949757 QLLRRESsVGYRVPA molecular association, regulation cell motility, altered; cell motility, inhibited HRas(INDUCES) 21209314; 27137893 2 4 5 -TGM2 TGM2 EC 2.3.2.13; KINASE; Transferase P21980 7052 20q11.23 human S215-p 467222 GRDCSRRsSPVYVGR molecular association, regulation 14-3-3 epsilon(INDUCES) 16870138 1 1 0 -LIG1 LIG1 DNA repair, damage; EC 6.5.1.1; Ligase P18858 3978 19q13.33 human K795-m1 58123203 EELQAICkLGTGFSD DNA_ligase_A_C molecular association, regulation L3MBTL iso4(INDUCES) 23583077 0 1 0 -TDP1 TDP1 DNA repair, damage; EC 3.1.4.-; Phosphodiesterase Q9NUW8 55775 14q32.11 human S81-p 11279401 PKRQKSGsQEDLGWC protein stabilization; molecular association, regulation; intracellular localization; protein conformation XRCC1(INDUCES); LIG3(INDUCES) 19851285; 20009512; 34181949 4 2 0 -TTK TTK Cancer Testis Antigen (CTA); EC 2.7.12.1; KINASE; Kinase, protein; Protein kinase, Other; Protein kinase, dual-specificity (non-receptor) P33981 7272 6q14.1 human S582-p 4145513 LNKLQQHsDKIIRLY Pkinase enzymatic activity, induced 18680479 1 0 0 in vitro -Kcnk18 KCNK18 Channel, ligand-gated; Channel, potassium; Membrane protein, integral; Membrane protein, multi-pass Q6VV64 332396 19|19 D3 mouse S276-p 12525800 VLGRLSCsILSNLDE activity, induced; protein conformation; activity, inhibited 14981085; 20215114; 22145024; 29763475; 32641496 8 0 0 -STIL STIL Cell cycle regulation; Cell development/differentiation; Oncoprotein Q15468 6491 1p33 human S1116-p 17400758 LISPNNMsFATKKYM molecular association, regulation; intracellular localization cell cycle regulation; cytoskeletal reorganization SAS6(INDUCES) 26101219; 31115335 3 2 0 -Cdh5 CDH5 Cell adhesion; Membrane protein, integral; Motility/polarity/chemotaxis P55284 12562 8 D3|8 53.04 cM mouse Y685-p 455658 MDARPAVyTQVQKPP receptor internalization, induced; molecular association, regulation; phosphorylation endocytosis, induced; cell growth, altered CSK(INDUCES) 15861137; 33550461; 37237266 18 4 145 decreases vessel maturation -Ulk1 ULK1 Autophagy; EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, Other; Protein kinase, Ser/Thr (non-receptor) O70405 22241 5|5 F mouse T754-gl 231166706 SPAPVVFtVGSPPSG molecular association, regulation AMPKA1(INDUCES) 28903979 2 0 0 -RECQL4 RECQL4 EC 3.6.4.12; Helicase O94761 9401 8q24.3 human T93-p 40722275 ATKSPQStPGRSRQG Drc1-Sld2 molecular association, regulation WDHD1(INDUCES); GINS4(INDUCES) 31519754 1 3 0 induces activation of replication origin -mos MOS EC 2.7.11.1; KINASE; Kinase, protein; Oncoprotein; Protein kinase, Other; Protein kinase, Ser/Thr (non-receptor) P12965 397924 frog S105-p 466947 NSLASRQsFWAELNA Pkinase enzymatic activity, inhibited 16809767 1 1 0 dephosphorylation of S105 is necessary for the mitotic activation of Mos -Camk1d CAMK1D EC 2.7.11.17; KINASE; Kinase, protein; Protein kinase, CAMK; Protein kinase, Ser/Thr (non-receptor) Q8BW96 227541 2|2 A1 mouse T180-p 450469 GKGDVMStACGTPGY Pkinase enzymatic activity, induced 33417706 2 5 15 -FUS hnRNP P2 DNA-binding; Nuclear receptor co-regulator; Oncoprotein; RNA splicing; RNA-binding; SUMO LIGASE P35637 2521 16p11.2 human Y526-p 50318713 QDRRERPy_______ molecular association, regulation; intracellular localization KPNB2(DISRUPTS) 26403203; 37071594 2 0 0 -ANKRD28 ANKRD28 Protein phosphatase, regulatory subunit O15084 23243 3p25.1 human S1007-p 459224 INRYTNTsKTVSFEA intracellular localization transcription, inhibited PPP1CA(DISRUPTS) 16564677; 17023142 2 1 0 -Rcan1 RCAN1 Inhibitor Q9JHG6 54720 16 C4|16 53.6 cM mouse S161-p 456022 PDKQFLIsPPASPPV Calcipressin molecular association, regulation PPP3CA(DISRUPTS) 22864830 7 34 5 -Trhr TRHR GPCR, family 1; Membrane protein, integral; Membrane protein, multi-pass; Receptor, GPCR Q01717 25570 7q31 rat T365-p 465592 KESDRFStELDDITV intracellular localization; receptor internalization, altered 11278484; 17329249; 17989235; 20345371 5 0 0 -YWHAB 14-3-3 beta Adaptor/scaffold P31946 7529 20q13.12 human S186-p 449845 FYYEILNsPEKACSL 14-3-3 molecular association, regulation Abl iso2(DISRUPTS) 15696159 3 5 0 -MDM2 MDM2 EC 6.3.2.-; EC 6.3.2.19; Inhibitor; Ligase; NEDDYLATION LIGASE; Neddylation Ligase; Nucleolus; Oncoprotein; UBIQUITIN LIGASE; Ubiquitin conjugating system; Ubiquitin ligase Q00987 4193 12q15 human S121-p 15714602 ESSDSGTsVSENRCH protein degradation; molecular association, regulation; ubiquitination FBW1B(INDUCES) 20708156 2 1 0 -G6PD G6PD Carbohydrate Metabolism - pentose phosphate pathway; Cell development/differentiation; EC 1.1.1.49; Other Amino Acids Metabolism - glutathione; Oxidoreductase P11413 2539 Xq28 human Y503-p 454849 MKRVGFQyEGTYKWV G6PD_C protein degradation; molecular association, regulation; enzymatic activity, inhibited; protein conformation apoptosis, induced p53(INDUCES); G6PD(DISRUPTS) 37798264 1 28 962 induction of apoptotic signaling; negatively regulates dimerization; reshaped the dimer interface and propagated to the substrate binding -KIF20A KIF20A Microtubule-binding; Motor O95235 10112 5q31.2 human S244-p 459830 LSTSLKRsVYIESRI Kinesin intracellular localization; activity, inhibited chromatin organization, altered 28630147 1 5 0 inhibits microtubule bundling activity but not microtubule binding -Guk1 GUK1 EC 2.7.4.8; KINASE; Kinase, other; Nucleotide Metabolism - purine Q64520 14923 11|11 B1.3 mouse S37-p 7493500 SIFGFSVsHTTRNPR Guanylate_kin enzymatic activity, induced cell growth, altered 19136674 1 0 0 Mutants display a drug resistance phenotype to 6-GT and decreased enzymatic activity. -STK3 MST2 Autophagy; EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, STE; Protein kinase, Ser/Thr (non-receptor) Q13188 6788 8q22.2 human S316-p 468210 LEEEEENsDEDELDS molecular association, regulation; ubiquitination; intracellular localization; phosphorylation cell cycle regulation; carcinogenesis, induced NEK2(DISRUPTS) 21723128; 37739411 2 57 12 TRIM69 regulates centrosome dynamics and mitotic progression and centrosome amplification, regulates centrosome clustering, promotes triple-negative breast cancer; TRIM69A regulates MST2 ubiquitination and intracellular localization -HNRNPA2B1 hnRNP A2/B1 iso2 RNA splicing; RNA-binding; Spliceosome P22626-2 3181 7p15.2 human K174-ub 1877221604 GHNAEVRkALSRQEM protein degradation carcinogenesis, inhibited; cell growth, inhibited 32826868 1 0 0 -MERTK Mer EC 2.7.10.1; KINASE; Kinase, protein; Membrane protein, integral; Oncoprotein; Protein kinase, TK; Protein kinase, tyrosine (receptor) Q12866 10461 2q13 human Y753-p 449989 KKIYSGDyYRQGRIA PK_Tyr_Ser-Thr enzymatic activity, induced 8702477 1 15 396 -SIGLEC9 Siglec-9 Membrane protein, integral; Receptor, misc. Q9Y336 27180 19q13.41 human Y433-p 464275 VGEGELQyASLSFQM transcription, inhibited; signaling pathway regulation 33431669 1 0 1 inhibits TLR4 signaling -Hnrnpf hnRNP F RNA splicing; RNA-binding; Spliceosome Q794E4 64200 4q42 rat K87-ub 12245479 HRYIEVFkSHRTEMD protein stabilization RNA splicing, induced 25959059 1 8 21 -NCOR2 SMRT Nuclear receptor co-regulator; Transcription, coactivator/corepressor Q9Y618 9612 12q24.31 human T1383-p 3217644 KLLKREGtPPPPPPS intracellular localization signaling pathway regulation 26778753 1 46 27 inhibits Wnt/beta-catenin signaling in HCC -MYH9 MYH9 Actin-binding; Motility/polarity/chemotaxis; Motor P35579 4627 22q12.3 human T1800-p 2482302 KLQEMEGtVKSKYKA Myosin_tail_1 intracellular localization cytoskeletal reorganization 18394644 1 1 1 -H3C1 H3 DNA-binding P68431 8350 6p22.2 human K79-me 1458617 REIAQDFkTDLRFQS Histone molecular association, regulation 53BP1(INDUCES) 15525939 8 2 0 -H3C1 H3 DNA-binding P68431 8350 6p22.2 human K4-me 1668802 ____ARTkQTARKST Histone molecular association, regulation; acetylation; intracellular localization; methylation carcinogenesis, induced; cell motility, induced; cell growth, induced; cell differentiation, induced; chromatin organization, altered; transcription, induced; transcription, altered CHD-7(INDUCES); HDAC1(DISRUPTS); MTA2(DISRUPTS); HP1 alpha(DISRUPTS) DNA(INDUCES) 11779497; 11850410; 12482974; 17391001; 18628788; 19251738; 19377461; 20829218; 20959362; 23772023; 27572339; 27716482 29 1 0 epithelial-mesenchymal transition (EMT), facilitated the H3K4me demethylation; promotes H3K4 methylation; decreases H3K27 trimethylation -ARRB2 ARRB2 iso2 Adaptor/scaffold P32120-2 281638 cow T382-p 455373 EFETNYAtDDDIVFE molecular association, regulation TRPV1(DISRUPTS) 23360390 5 3 2 -PLCB3 PLCB3 Carbohydrate Metabolism - inositol phosphate; EC 3.1.4.11; Phospholipase Q01970 5331 11q13.1 human S1105-p 448448 LDRKRHNsISEAKMR PLC-beta_C enzymatic activity, inhibited 9660757 5 22 216 -Cdh1 CDH1 Cell adhesion; Membrane protein, integral; Motility/polarity/chemotaxis; UBIQUITIN LIGASE; Ubiquitin ligase P09803 12550 8 D3|8 53.18 cM mouse S848-p 15754601 GSEAASLsSLNSSES CADH_Y-type_LIR molecular association, regulation CTNNB1(INDUCES) 11348595 1 1 0 -Cd79a Ig-alpha Immunoglobulin superfamily; Membrane protein, integral P11911 12518 7 A3|7 13.49 cM mouse Y193-p 473329 NLDDCSMyEDISRGL ITAM activity, induced; molecular association, regulation; phosphorylation cell differentiation, altered; signaling pathway regulation Syk(INDUCES) 11859098; 11909947; 17163454; 9531288 4 1 25 Ca(2+) signaling -ACKR3 CMKOR1 GPCR, family 1; Membrane protein, integral; Membrane protein, multi-pass; Receptor, GPCR P25106 57007 2q37.3 human T352-p 4709314 DASRVSEtEYSALEQ receptor internalization, induced; molecular association, regulation; intracellular localization ARRB1(INDUCES) 33799570 2 3 0 -HIF1A HIF1A Autophagy; DNA-binding; Transcription factor Q16665 3091 14q23.2 human S31-p 56589706 DAARSRRsKESEVFY molecular association, regulation; activity, inhibited transcription, inhibited DNA(DISRUPTS) 34285132 2 1 0 -PYCR1 PYCR1 Amino Acid Metabolism - arginine and proline; EC 1.5.1.2; Mitochondrial; Oxidoreductase P32322 5831 17q25.3 human K228-ac 1878196105 EQHPGQLkDNVSSPG enzymatic activity, inhibited cell growth, inhibited PYCR1(INDUCES) 31108370 1 0 0 Acetylation of K228 impairs the formation of decamers and inhibits enzymatic activity -SLC14A2 SLC14A2 Membrane protein, integral; Membrane protein, multi-pass; Transporter; Transporter, SLC family Q15849 8170 18q12.3 human S477-p 2813501 AVLSKHRsVFHIEWS ubiquitination 24133116 10 2 3 mutant reduces forskolin induced SLC14AZ ubiquitination -Vangl2 VANGL2 Adaptor/scaffold; Membrane protein, integral; Membrane protein, multi-pass Q91ZD4 93840 1 H3|1 79.54 cM mouse S5-p 18460402 ___MDTEsQYSGYSY activity, induced; protein stabilization 21316585 1 0 0 -STK11 LKB1 Autophagy; EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, CAMK; Protein kinase, Ser/Thr (non-receptor); Tumor suppressor Q15831 6794 19p13.3 human S307-p 7710000 IRQIRQHsWFRKKHP Pkinase molecular association, regulation; intracellular localization apoptosis, altered; cell growth, altered Exportin-1(INDUCES); AMPKA1(INDUCES); STRAD(INDUCES) 19414597 2 0 0 in the presence of ONOO(-); supresses angiogenesis -HDAC3 HDAC3 Apoptosis; Cell cycle regulation; DEACETYLASE; Deacetylase; EC 3.5.1.98; Nuclear receptor co-regulator; Transcription, coactivator/corepressor O15379 8841 5q31.3 human Y298-p 1884166702 LVLGGGGyTVRNVAR carcinogenesis, induced; cell motility, induced; transcription, induced 34973135 1 0 0 -Ppp1r12a MYPT1 Motility/polarity/chemotaxis; PHOSPHATASE; Protein phosphatase, regulatory subunit Q9DBR7 17931 10 D1|10 56.33 cM mouse K442-m1 1872438900 SWRLGLRkTGSYGAL protein stabilization 21115810 1 0 0 -Stxbp5l STXBP5L Q5DQR4 207227 16 26.32 cM|16 B3 mouse K279-sm 31957312 SLTLWNLkSPSRPFQ neural plasticity 24614299 1 0 0 -SKAP1 SKAP55 Adaptor/scaffold; Motility/polarity/chemotaxis Q86WV1 8631 17q21.32 human Y219-p 451307 LSSLTIPyEEDEEEE molecular association, regulation CD45(INDUCES) 11909961 1 0 0 -Syn1 SYN1 Vesicle O88935 20964 X A1.3|X 16.37 cM mouse S9-p 448378 NYLRRRLsDSNFMAN Synapsin_N molecular association, regulation neural plasticity; signaling pathway regulation ACTB(DISRUPTS) 28698220; 31242289 25 5 2 intersynaptic vesicular trafficking; plays an important role in the developming visual cortex in mice -MARK2 MARK2 EC 2.7.11.1; EC 2.7.11.26; KINASE; Kinase, protein; Protein kinase, CAMK; Protein kinase, Ser/Thr (non-receptor) Q7KZI7 2011 11q13.1 human S212-p 450068 KLDTFCGsPPYAAPE Pkinase enzymatic activity, inhibited cell differentiation, altered; cytoskeletal reorganization 18424437 6 12 11 GSK3B coexpression inhibits MARK2 enzymatic activity. -NPM/ALK NPM-ALK KINASE; Kinase, protein; Protein kinase, TK; Protein kinase, tyrosine (receptor) AAA58698 human S164-p 27275103 CFAGKTSsISDLKEV phosphorylation carcinogenesis, altered; cell growth, altered 21045017 1 1 0 -HBP1 HBP1 DNA-binding; Transcription factor O60381 26959 7q22.3 human K419-ac 25171019 SLYAKAVkNHSSGTV molecular association, regulation cell cycle regulation; transcription, induced; transcription, inhibited DNA(INDUCES) 21967847; 23249948 2 0 0 acetylation of the five sites induces transcriptional repression of the DNMT1 gene, regulates cellular senescence -NFKB1 NFkB-p105 DNA-binding; Transcription factor P19838 4790 4q24 human S932-p 447771 CDSGVETsFRKLSFT protein degradation 10469655; 12482991 6 0 0 -Nr1h4 NR1H4 DNA-binding; Nuclear receptor Q60641 20186 10 C2|10 44.98 cM mouse Y77-p 1186568001 QISSSSYySNLGFYP transcription, induced 30996006 2 1 0 protection of mice from arthrosclerosis; increased mRNA expression levels of Scarb1 and Abcg1/5/8; maintains Cholestrol homeostasis (lowering cholestrol levels) -Dlg4 PSD-95 Adaptor/scaffold P31016 29495 10q24 rat S561-p 25680400 EFPDKFGsCVPHTTR Guanylate_kin protein conformation PSD-95(INDUCES) 28790172 2 1 0 GK domain forms an intramolecular interaction with the adjacent SH3 domain, spine structural plasticity -SLK SLK EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, STE; Protein kinase, Ser/Thr (non-receptor) Q9H2G2 9748 10q24.33-q25.1 human S189-p 468769 RTIQRRDsFIGTPYW Pkinase molecular association, regulation; phosphorylation; enzymatic activity, induced apoptosis, induced SLK(INDUCES) 22203681; 28475647 2 45 305 induces phosphorylation of JNK and p38, homodimerization induces kinase activity -ADAM22 ADAM22 Cell adhesion; Membrane protein, integral; Motility/polarity/chemotaxis Q9P0K1 53616 7q21.12 human S834-p 469108 NGRPRSNsWQGNLGG protein stabilization; molecular association, regulation; intracellular localization 14-3-3 beta(INDUCES); 14-3-3 theta(INDUCES); 14-3-3 zeta(INDUCES); 14-3-3 epsilon(INDUCES); 14-3-3 gamma(INDUCES); 14-3-3 eta(INDUCES) 16868027 2 24 97 -MAP2K4 MKK4 EC 2.7.12.2; KINASE; Kinase, protein; Protein kinase, STE; Protein kinase, dual-specificity (non-receptor) P45985 6416 17p12 human T261-p 447656 LVDSIAKtRDAGCRP Pkinase enzymatic activity, induced cell cycle regulation; carcinogenesis, induced; cell growth, induced; transcription, induced 10727406; 15328343; 35843311; 9162092 26 3 1 -SPOP SPOP UBIQUITIN LIGASE; Ubiquitin ligase O43791 8405 17q21.33 human S6-p 36136244 __MSRVPsPPPPAEM protein stabilization; molecular association, regulation FZR1(DISRUPTS); 14-3-3 gamma(INDUCES) 29160310 1 4 0 -NEDD1 NEDD1 Cell cycle regulation Q8NHV4 121441 12q23.1 human S566-p 25533016 VTAGVASsLSEKIAD molecular association, regulation cytoskeletal reorganization TUBG1(INDUCES) 22595525 1 1 0 Promote NEDD1 activity; regulates spindle assembly in mitosis -NCF1 p47phox EC 1.-.-.-; Oxidoreductase P14598 653361 7q11.23 human S359-p 451729 EERQTQRsKPQPAVP p47_phox_C activity, induced; molecular association, regulation; intracellular localization; enzymatic activity, induced; phosphorylation CYBA(INDUCES) 12056906; 9857051 12 0 0 -Ubtf UBF DNA-binding; Nucleolus; Transcription factor P25976 21429 11|11 D mouse S389-p 450170 INKKQTTsPASKKPS transcription, altered 11698641 4 3 1 -Zc3h12a MCPIP1 EC 3.1.-.-; Hydrolase Q5D1E7 230738 4|4 D2.2 mouse S494-p 56659543 AMGAGHFsVPTDYVP protein stabilization; molecular association, regulation; intracellular localization RNA stability, induced 14-3-3 beta(INDUCES); MCPIP1(DISRUPTS) RNA(DISRUPTS) 31072819; 34636324 2 2 0 -RXRA RXRA DNA-binding; Motility/polarity/chemotaxis; Nuclear receptor P19793 6256 9q34.2 human S78-p 333674902 PMGPHSMsVPTTPTL Nuc_recep-AF1 ubiquitination carcinogenesis, induced; transcription, induced; signaling pathway regulation 29137318; 30518934 2 0 0 PI3K/AKT signaling ; PIK3CA transcription; negatively regulated beta-catenin expression by ubiquitination of ?-catenin in CRC -PAN2 USP52 DEUBIQUITINASE; EC 3.1.13.4; Ribonuclease; Ubiquitin-specific protease Q504Q3 9924 12q13.3 human S1003-p 50792538 TKSTIKPsQMSVARI RNase_T molecular association, regulation; ubiquitination; enzymatic activity, induced DNA repair, induced POLR1B(INDUCES); RAD51(INDUCES) 33097710 1 1 0 Increase deubiquitination/regulates CtIP deubiquitination -THRA TR-alpha DNA-binding; Nuclear receptor; Transcription factor NP_990644 396251 chicken K132-ac 10769109 DDSKRVAkRKLIEEN molecular association, regulation carcinogenesis, inhibited; transcription, altered SMRT(DISRUPTS); ACTR1A(INDUCES) DNA(INDUCES) 19819978 1 0 0 induces transactivation and transrepression of transcription -Ensa ENSA Inhibitor; Protein phosphatase, regulatory subunit P60840 56205 3|3 F2.1 mouse S67-p 455934 KGQKYFDsGDYNMAK Endosulfine cell cycle regulation; signaling pathway regulation 30293837 5 68 47 part of MASTL-ENSA-PP2A pathway -PRKAB1 AMPKB1 Autophagy; KINASE; Protein kinase, regulatory subunit Q9Y478 5564 12q24.23 human T148-p 7447514 IVTSQLGtVNNIIQV AMPK1_CBM molecular association, regulation Other(DISRUPTS) 25792737 1 2 1 loss of carbohydrate binding ability, 148D mutant prevents binding to cellular glycogen -Sox9 SOX9 DNA-binding; Transcription factor F1LYL9 140586 rat K62-ac 1881321501 KGEPDLKkESEEDKF intracellular localization cell growth, induced; transcription, induced 34156114 1 1 0 Binding of SOX9 to FGF1 or PDGF-alpha promoter -PARP1 PARP1 DNA repair, damage; EC 2.4.2.30; Nuclear envelope; Nuclear receptor co-regulator; Nucleolus; Transferase P09874 142 1q42.12 human S785-p 21440500 LRGGSDDsSKDPIDV PARP_reg intracellular localization; enzymatic activity, inhibited; enzymatic activity, induced 21922195; 25069723 2 2 0 Non-apoptotic cell death induced -ACADVL ACADVL EC 1.3.8.9; Lipid Metabolism - fatty acid; Mitochondrial; Oxidoreductase P49748 37 17p13.1 human S586-p 22680600 VVVLSRAsRSLSEGH enzymatic activity, induced cell growth, induced; apoptosis, inhibited 19889959 1 1 0 -ACTB ACTB Cytoskeletal; Motility/polarity/chemotaxis P60709 60 7p22.1 human K68-sm 9859926 KRGILTLkYPIEHGI Actin intracellular localization 19635839 1 0 0 nuclear localization -SCN5A SCN5A Channel, sodium; Membrane protein, integral; Membrane protein, multi-pass Q14524 6331 3p22.2 human S671-p 1871776501 SAVSVLTsALEELEE intracellular localization; protein conformation; activity, inhibited 33410863 1 1 0 -Dnm1 DYN1 EC 3.6.5.5; Hydrolase; Microtubule-binding; Motility/polarity/chemotaxis; Motor; Vesicle P21575 140694 3p12 rat S778-p 450206 GRRSPTSsPTPQRRA molecular association, regulation endocytosis, altered endophilin A1(INDUCES); PACSIN1(INDUCES); PACSIN1(DISRUPTS) 16648848; 17437541 14 24 6 regulates synaptic vesicle endocytosis; interaction essential for synaptic vesicle endocytosis -Mybpc3 MYBPC3 Myosin-binding O70468 17868 2|2 E1 mouse S273-p 471079 RSAFRRTsLAGAGRR activity, induced; molecular association, regulation; intracellular localization; protein conformation apoptosis, altered; cytoskeletal reorganization MYBPC1(DISRUPTS) 17075052; 21978630; 22752314; 24951619; 25740838; 26908877; 28167762 25 9 14 phosphorylation weakens this stabilization and binding of the heads to the backbone, increasing the probability of their interacting with the thin filament -CKMT2 CKMT2 Amino Acid Metabolism - arginine and proline; EC 2.7.3.2; Kinase, other; Mitochondrial P17540 1160 5q14.1 human Y255-p 1914505 ARGIWHNyDKTFLIW ATP-gua_Ptrans enzymatic activity, induced transcription, induced; signaling pathway regulation 34095014 1 2 41 induces PGC-1a/estrogen-related receptor-a pathway -OLA1 OLA1 EC 3.6.3.-; Hydrolase; Nucleolus Q9NTK5 29789 2q31.1 human T124-p 1883583904 CDGIFHLtRAFEDDD protein degradation; molecular association, regulation; ubiquitination; intracellular localization AurA(INDUCES) 37481721 1 0 0 -TFAM TFAM DNA-binding; Transcription regulation Q00059 7019 10q21.1 human K69-ac 1876567504 KEQLPIFkAQNPDAK HMG_box transcription, induced 35278431 0 1 0 -RANGAP1 RANGAP1 GAP; GAP, Ras P46060 5905 22q13.2 human S506-p 1873645606 QKAFNSSsFNSNTFL RanGAP1_C sumoylation; intracellular localization 34110283 1 0 0 WT RANGAP1 rescues nuclear import of NF-ATc1, NF-kB, AP-1 in RanGAP1 (KD), required in various nuclear transport pathways -PIGR PIGR Immunoglobulin superfamily; Membrane protein, integral; Receptor, misc. P01832 100328593 rabbit S744-p 451444 PKKAKRSsKEEADLA intracellular localization 8343953 1 5 0 Mutation of S744 drastically reduces transcytosys of dIgA. -Akt1 Akt1 EC 2.7.11.1; KINASE; Kinase, protein; Oncoprotein; Protein kinase, AGC; Protein kinase, Ser/Thr (non-receptor) P47196 24185 6q32 rat T34-p 455493 FLLKNDGtFIGYKER PH enzymatic activity, inhibited 14560023 2 1 1 -Kcnab2 Kv-beta2 Channel, potassium P62483 29738 5q36 rat S9-p 486012 YPESTTGsPARLSLR activity, induced; molecular association, regulation; intracellular localization EB1(DISRUPTS) 21357749 2 20 7 -RAD9A RAD9A Apoptosis; Cell cycle regulation; DNA replication; Deoxyribonuclease; EC 3.1.11.2 Q99638 5883 11q13.2 human S272-p 447824 LSDTDSHsQDLGSPE activity, induced; ubiquitination cell cycle regulation; DNA repair, induced 11278446; 22453082; 26658951 7 5 7 controls repair pathways, maintenance of replication fork stability -Nfasc neurofascin Membrane protein, integral; Motility/polarity/chemotaxis P97685 116690 13q13 rat Y1212-p 452190 DGSFIGQyTVRKDKE Bravo_FIGEY molecular association, regulation ANK1(DISRUPTS) 9151675 1 0 0 -Nr3c1 GR DNA-binding; Mitochondrial; Nuclear receptor; Transcription factor P06536 24413 18p11 rat S232-p 447968 PSKDTNEsPWRSDLL GCR activity, induced; intracellular localization transcription, altered 18304804; 25330740 51 5 0 induces hormone-dependent recruitment of GR to promoters (of tat, sult and gliz genes) -TH TH iso3 Amino Acid Metabolism - tyrosine; EC 1.14.16.2; Endoplasmic reticulum; Mitochondrial; Oxidoreductase; Vesicle P07101-3 7054 11p15.5 human S40-p 448545 RFIGRRQsLIEDARK TOH_N enzymatic activity, induced 12421349; 33456492; 7901013; 9920892 62 11 11 absence of S31 and S40 in an alternative spliced variant lacking exon 3 that has reduced enzymatic activity in vitro -Ndel1 NDEL1 Microtubule-binding; Protease Q9ERR1 83431 11|11 B3 mouse T245-p 3211851 GFGTSPLtPSARISA NUDE_C activity, induced; intracellular localization cell motility, altered 18331715 2 7 3 Cdc42 activation -Cycs CYCS Apoptosis; Mitochondrial; Oxidoreductase; PHOSPHATASE; Protein phosphatase, Ser/Thr (non-receptor) P62897 13063 6 B2.3|6 24.32 cM mouse T50-p 8086210 QAAGFSYtDANKNKG Cytochrom_C apoptosis, inhibited 35896004 1 2 1 -ETV1 ETV1 DNA-binding; Oncoprotein; Transcription factor P50549 2115 7p21.2 human T139-p 3059605 MRPSNPPtPSSTPVS ETS_PEA3_N activity, induced transcription, induced 12213813 2 0 0 -MDM2 MDM2 EC 6.3.2.-; EC 6.3.2.19; Inhibitor; Ligase; NEDDYLATION LIGASE; Neddylation Ligase; Nucleolus; Oncoprotein; UBIQUITIN LIGASE; Ubiquitin conjugating system; Ubiquitin ligase Q00987 4193 12q15 human S240-p 454919 GDWLDQDsVSDQFSV activity, induced 12167711 3 1 0 promotes p53 degradation -PDGFRB PDGFRB EC 2.7.10.1; KINASE; Kinase, protein; Membrane protein, integral; Oncoprotein; Protein kinase, TK; Protein kinase, tyrosine (receptor) P09619 5159 5q32 human Y716-p 447524 RPPSAELySNALPVG PK_Tyr_Ser-Thr activity, induced; molecular association, regulation GRB2(INDUCES); GRB7(INDUCES) 7935391; 8940081 5 1 2 -MRPL10 MRPL10 Mitochondrial; Ribosomal; Translation Q3MHY7 515014 cow K46-ac 12674400 VMHFERQkLMAVTEY translation, induced 20042612 1 1 0 downregulates protein synthesis -Jak2 JAK2 EC 2.7.10.2; KINASE; Kinase, protein; Oncoprotein; Protein kinase, TK; Protein kinase, tyrosine (non-receptor) Q62120 16452 19 C1|19 23.73 cM mouse S633-p 1880516404 QEFVKFGsLDTYLKK activity, inhibited carcinogenesis, induced; transcription, inhibited; signaling pathway regulation 36356831 1 0 0 regulates JAK2/STAT5 signaling pathway -SIRT2 SIRT2 DEACETYLASE; Deacetylase; EC 3.5.1.- Q8IXJ6 22933 19q13.2 human S368-p 482809 PNPSTSAsPKKSPPP enzymatic activity, inhibited cell motility, altered; cell adhesion, altered; cell growth, altered 17488717; 18332217 7 31 0 hyperphosphorylated during mitotic arrest; ; delay in cell growth of S368E mutant was observed; cell cycle-regulated phosphorylation -TP53BP1 53BP1 DNA repair, damage; Transcription, coactivator/corepressor Q12888 7158 15q15.3 human R1398-me 2344819 APVTPRGrGRRGRPP molecular association, regulation DNA(INDUCES) 16294045 2 0 0 -DAPP1 DAPP1 Adaptor/scaffold Q9UN19 27071 4q23 human Y139-p 448325 KVEEPSIyESVRVHT activity, induced; molecular association, regulation; intracellular localization; phosphorylation carcinogenesis, inhibited; cytoskeletal reorganization; signaling pathway regulation SH2D1B(NOT_REPORTED); PLCG2(INDUCES) 10770799; 11102801; 15247305; 22981863; 23322602; 30131370 7 17 324 -Rb1 Rb Nuclear receptor co-regulator; Oncoprotein; Transcription, coactivator/corepressor; Tumor suppressor P13405 19645 14 38.73 cM|14 D3 mouse T364-p 450023 DEEANVVtPHTPVRT molecular association, regulation E2F1(DISRUPTS) 10207050 1 6 0 -Sv2a SV2A Membrane protein, integral; Membrane protein, multi-pass; Vesicle Q9JIS5 64051 3|3 F2.1 mouse T84-p 4779764 GGASSDAtEGHDEDD molecular association, regulation SYT1(INDUCES) 25673844 1 9 10 SV2A retrieval during SV endocytosis, Thr84 of SV2A is critical in promoting the interaction with synaptotagmin-1 -Cldn16 Claudin-16 Cell adhesion; Membrane protein, integral; Membrane protein, multi-pass Q91Y55 155268 11q22 rat T225-p 11555105 YKAPRTEtAKMYAVD intracellular localization 19914201 1 0 0 -Ezr Ezrin Cytoskeletal; Motility/polarity/chemotaxis P31977 54319 1q11 rat T567-p 448104 QGRDKYKtLRQIRQG ERM_C intracellular localization cytoskeletal reorganization 16938849; 34054551 68 9 16 regulates endothelial hyperpermeability -Cul5 CUL5 UBIQUITIN LIGASE; Ubiquitin conjugating system; Ubiquitin ligase Q9JJ31 64624 8q24 rat S730-p 963800 MKMRKKIsNAQLQTE Cullin_Nedd8 cytoskeletal reorganization; cell growth, altered 17950367 5 0 0 S730 phosphorylation may regulate angiogenisis. -WRN WRN Cell cycle regulation; DNA repair, damage; DNA-binding; EC 3.6.4.12; Helicase; Nucleolus Q14191 7486 8p12 human S426-p 3196115 YKSTEHLsPNDNEND molecular association, regulation; intracellular localization DNA repair, altered RPA1(INDUCES) 34612580 1 10 0 -MAP3K11 MLK3 EC 2.7.11.25; KINASE; Kinase, protein; Protein kinase, Ser/Thr (non-receptor); Protein kinase, TKL Q16584 4296 11q13.1 human S793-p 448613 PRPSPLPsPQPAPRR enzymatic activity, induced apoptosis, induced 17711861 2 21 6 induces activation of itself and JNK -Khdrbs1 KHDRBS1 RNA-binding Q60749 20218 4|4 D2.2 mouse T84-p 449878 TVVGSAPtPLLPPSA activity, induced translation, altered 12478298 1 2 5 regulates splicing -Rnf10 RNF10 Ubiquitin conjugating system Q3UIW5 50849 5 F|5 56.01 cM mouse S31-p 1868450200 SSASSGSsKGQQPPR molecular association, regulation; intracellular localization neural plasticity; signaling pathway regulation NMDAR2A(DISRUPTS) 31069631 1 0 0 CREB signaling -TEK TIE2 EC 2.7.10.1; KINASE; Kinase, protein; Membrane protein, integral; Protein kinase, TK; Protein kinase, tyrosine (receptor) Q02763 7010 9p21.2 human S1119-p 453441 TYAGIDCsAEEAA__ activity, induced; enzymatic activity, induced 25320242 2 3 0 personal communication from Dr Chris Kontos , Duke University; activation promoted tight-junction stabilization and endothelial barrier protective effects -Nfatc2 NFAT1 DNA-binding; Transcription factor Q60591 18019 2 H3|2 88.91 cM mouse S365-p 449627 EQEERRNsAPESILL transcription, inhibited 11030334 0 13 6 -TP53 p53 Activator; DNA-binding; Motility/polarity/chemotaxis; Nuclear receptor co-regulator; Transcription factor; Tumor suppressor P04637 7157 17p13.1 human S315-p 447530 LPNNTSSsPQPKKKP activity, induced; protein degradation; molecular association, regulation; ubiquitination; intracellular localization; protein conformation; activity, inhibited cell cycle regulation; carcinogenesis, induced; apoptosis, altered; cell motility, induced; apoptosis, induced; cell motility, inhibited; transcription, induced; transcription, altered; cell growth, induced; apoptosis, inhibited; cell motility, altered; transcription, inhibited; cell growth, altered PIN1(INDUCES); NFkB-p100(DISRUPTS); p53(DISRUPTS) DNA(INDUCES); DNA(DISRUPTS) 11078726; 11687964; 12397361; 12397362; 14702041; 14744935; 15619621; 16037820; 16227590; 17906639; 18769132; 20661218; 20808790; 25691063; 26588988; 30266789; 33649292; 34798143; 35217309; 35393542; 36167685; 36371602; 7596441 49 32 7 -KLF3 KLF3 C2H2-type zinc finger protein; DNA-binding; Transcription factor P57682 51274 4p14 human K10-sm 3617604 MFDPVPVkQEAMDPV molecular association, regulation transcription, inhibited 15684403 1 1 0 -Gabbr2 GABBR2 GPCR, family 3; Membrane protein, integral; Membrane protein, multi-pass; Receptor, GPCR O88871 83633 5q22 rat S892-p 450809 EHIQRRLsLQLPILH activity, induced; protein stabilization 11976702; 14707142 6 1 0 -Esr1 ER-alpha DNA-binding; Nuclear receptor; Transcription factor P19785 13982 10 A1|10 2.03 cM mouse S122-p 448101 LHPPPQLsPFLHPHG Oest_recep transcription, altered 8541227 93 2 0 A reduction of basal transcriptional activity was observed when S122 was mutated. The effect of the replacement was increased by the introduction of mutations into AF-2 in the hormone binding domain. Optimum phosphorylation of S122 is dependent on the phosphorylation of S298. -BAK1 BAK1 Apoptosis; Endoplasmic reticulum; Membrane protein, integral; Mitochondrial Q16611 578 6p21.31 human S117-p 27276102 YFTKIATsLFESGIN Bcl-2 molecular association, regulation; protein conformation; activity, inhibited apoptosis, inhibited; signaling pathway regulation BAK1(DISRUPTS) 23189150 1 1 0 S117 dephosphorylation is required for BAK multimerization -PDCD5 PDCD5 Apoptosis O14737 9141 19q13.11 human S119-p 452536 NRRKVMDsDEDDDY_ protein degradation; protein stabilization; molecular association, regulation; ubiquitination; intracellular localization carcinogenesis, inhibited; apoptosis, induced; cell adhesion, altered IPO13(INDUCES) 19616514; 26077467; 28051100 3 75 262 -IGFBP1 IGFBP1 Secreted; Secreted, signal peptide P08833 3484 7p12.3 human S194-p 451660 LAKAQETsGEEISKF Thyroglobulin_1 activity, induced; molecular association, regulation; activity, inhibited; phosphorylation signaling pathway regulation IGF1(INDUCES); CK2B(INDUCES) 18772238; 20143870; 25957086; 32502935 15 15 0 regulates mTOR and AAR signaling; inhibits IGF-1RB autophosphorylation and activity -CNTROB LIP8 Cell cycle regulation Q8N137 116840 17p13.1 human S45-p 27565614 LYASLRLsRQAEATA cell motility, inhibited 23291182 1 0 0 -MAT1A MAT1A Amino Acid Metabolism - cysteine and methionine; EC 2.5.1.6; Other Amino Acids Metabolism - selenoamino acid; Transferase Q00266 4143 10q22.3 human S180-p 1874404502 LPWLRPDsKTQVTVQ S-AdoMet_synt_M protein degradation; molecular association, regulation; intracellular localization carcinogenesis, induced; cell motility, induced; cell growth, induced; transcription, induced 14-3-3 zeta(INDUCES) 34349244 1 0 0 -NDEL1 NDEL1 Microtubule-binding; Protease Q9GZM8 81565 17p13.1 human S198-p 474508 TRKSAPSsPTLDCEK NUDE_C molecular association, regulation; intracellular localization PAFAH1B1(INDUCES); DYNC1I1(INDUCES) 12556484; 37086789 4 25 0 -SIGIRR SIGIRR Membrane protein, integral; Receptor, misc. Q6IA17 59307 11p15.5 human T372-p 1873759800 EPSAPPHtSGVSLGE receptor internalization, induced; protein degradation; molecular association, regulation USP13(DISRUPTS) 33400290 1 0 0 -Stat1 STAT1 DNA-binding; Transcription factor P42225 20846 1 C1.1|1 26.81 cM mouse S727-p 447753 TDNLLPMsPEEFDEM STAT1_TAZ2bind activity, induced; sumoylation; protein degradation; molecular association, regulation; activity, inhibited; phosphorylation cell cycle regulation; cell growth, inhibited; cell motility, induced; apoptosis, induced; transcription, induced; signaling pathway regulation; transcription, altered; cell differentiation, induced; transcription, inhibited; cell growth, altered BTRC(INDUCES) DNA(INDUCES) 11226159; 12671680; 12748197; 14670297; 17255531; 17346795; 18378670; 18941537; 21636857; 23352233; 34124936; 34303919; 34560245; 34569651; 35394840; 37352855 118 32 90 -CDK5R2 CDK5R2 Protein kinase, regulatory subunit Q13319 8941 2q35 human T84-p 4697544 KKGSKKVtPKPASTG intracellular localization 22467861 1 4 0 CDK5R2 S8 in its unphosphorylated form accumulates at the perinuclear region and T84 plays a role in the nuclear localization of CDK5R2. -Arrb2 ARRB2 Adaptor/scaffold P29067 25388 10q24 rat T178-p 36120700 KVQFAPEtPGPQPSA receptor recycling, inhibited; protein stabilization signaling pathway regulation 25016018 1 0 0 stabilizes B2R/ARRB2 complexes, receptor recycling to plasma membrane is delayed -Spry1 SPRY1 Adaptor/scaffold; Inhibitor; Motility/polarity/chemotaxis Q9QXV9 24063 3|3 B mouse Y53-p 454589 AIRGSNEyTEGPSVA activity, induced signaling pathway regulation 22508938 3 18 234 -PML PML Nucleolus; Oncoprotein; SUMO LIGASE; SUMO conjugating system; SUMO ligase; Transcription factor; Tumor suppressor; Ubiquitin conjugating system P29590 5371 15q24.1 human S561-p 6835503 ERVVVISsSEDSDAE DUF3583 molecular association, regulation SUMO2(INDUCES); SUMO1(INDUCES); SUMO3(INDUCES) 19217413; 19380586 2 6 0 PML interaction with SUMO-modified protein partners and PML nuclear bodies maturation -Gch1 GCH1 Cofactor and Vitamin Metabolism - folate biosynthesis; EC 3.5.4.16; Hydrolase P22288 29244 15p14 rat T103-p 10428810 FTKGYQEtISDVLND GTP_cyclohydroI enzymatic activity, induced 19762783 1 0 0 -MFF MFF iso2 Membrane protein, integral; Mitochondrial Q9GZY8-2 56947 2q36.3 human K251-ub 41529300 SLRRQIIkLNRRLQL Miff molecular association, regulation autophagy, induced SQSTM1(INDUCES) 26008206 2 1 0 promotes p62/SQSTM1 recruitment during mitochondrial depolarization -Fkbp3 FKBP3 EC 5.2.1.8; Isomerase Q62446 30795 12|12 C1 mouse S163-p 4935796 KKNAKPLsFKVGVGK FKBP_C cell cycle regulation 33553183 1 6 6 -YY1 YY1 C2H2-type zinc finger protein; Cell development/differentiation; Transcription factor P25490 7528 14q32.2 human S365-p 15416769 EGCGKRFsLDFNLRT zf-C2H2 molecular association, regulation DNA(INDUCES) 28855673 2 5 3 overlaps but is not needed for the linker phosphorylation of YY1 -Add1 ADD1 Cytoskeletal; Motility/polarity/chemotaxis Q63028 24170 14q21 rat S714-p 449828 GSPGKSPsKKKKKFR intracellular localization cytoskeletal reorganization 9679146 5 1 0 -CUX1 CUTL1 DNA-binding; Membrane protein, integral; Transcription factor P39880 1523 7q22.1 human S1270-p 460701 YQQKPYPsPKTIEDL Homeodomain transcription, inhibited 16574653 1 16 0 -CLSPN claspin Actin-binding; Cell cycle regulation Q9HAW4 63967 1p34.3 human S945-p 455335 EELLNLCsGKFTSQD molecular association, regulation Chk1(INDUCES) 15707391 2 2 0 -PKM PKM Carbohydrate Metabolism - glycolysis and gluconeogenesis; Carbohydrate Metabolism - pyruvate; EC 2.7.1.40; KINASE; Kinase, other; Mitochondrial; Nucleotide Metabolism - purine P14618 5315 15q23 human T454-p 23132420 RAPIIAVtRNPQTAR PK_C protein stabilization; enzymatic activity, induced carcinogenesis, induced; cell growth, induced; transcription, induced 24142698 2 2 1 reduces mitochondrial respiration -Bad BAD Apoptosis Q61337 12015 19|19 A mouse S170-p 447864 KGLPRPKsAGTATQM Bcl-2_BAD cell cycle regulation; cell growth, inhibited; apoptosis, inhibited 11717309; 22103330 6 22 3 -SREBF1 SREBP-1 DNA-binding; Membrane protein, integral; Membrane protein, multi-pass; Transcription factor P36956 6720 17p11.2 human S434-p 6729302 PPPSDAGsPFQSSPL protein degradation; molecular association, regulation; activity, inhibited; phosphorylation FBXW7(INDUCES) 19126544 1 0 0 -Trip6 TRIP6 Adaptor/scaffold; Motility/polarity/chemotaxis; Nuclear receptor co-regulator Q9Z1Y4 22051 5|5 G2 mouse Y55-p 456050 PLPPEHCyQPPGVPE molecular association, regulation; intracellular localization cytoskeletal reorganization P130Cas(INDUCES); CRK(INDUCES) 15988003; 20547766 5 4 43 -HBP1 HBP1 DNA-binding; Transcription factor O60381 26959 7q22.3 human K307-ac 25171016 HPFYVKNkGWSSFYP AXH transcription, inhibited 23249948 2 0 0 acetylation of the five sites induces transcriptional repression of the DNMT1 gene, regulates cellular senescence -JUNB JunB Motility/polarity/chemotaxis; Oncoprotein; Transcription factor P17275 3726 19p13.13 human T102-p 1814001 SNGVITTtPTPPGQY Jun activity, induced; molecular association, regulation transcription, altered DNA(INDUCES) 9889198 1 4 0 Phosphorylation of JunB increases cooperative binding with c-Maf to DNA. -PKM PKM Carbohydrate Metabolism - glycolysis and gluconeogenesis; Carbohydrate Metabolism - pyruvate; EC 2.7.1.40; KINASE; Kinase, other; Mitochondrial; Nucleotide Metabolism - purine P14618 5315 15q23 human S222-p 27110046 AVDLPAVsEKDIQDL PK molecular association, regulation carcinogenesis, induced; DNA repair, induced SSRP1(INDUCES); SPT16(INDUCES) 35048565 1 7 0 binding to FACT complex regulates FACT binding to H2AX -EPOR EPOR Membrane protein, integral; Receptor, cytokine P19235 2057 19p13.2 human Y426-p 449884 ASAASFEyTILDPSS activity, induced; molecular association, regulation; activity, inhibited; phosphorylation cell cycle regulation; apoptosis, induced; apoptosis, inhibited; signaling pathway regulation; cell growth, altered STAT5A(INDUCES); SHIP(INDUCES); SOCS3(INDUCES); CISH(INDUCES) 10455108; 10660611; 11290583; 12027890; 12441334; 12506011; 14662339 10 0 0 -NUTM1 NUTM1 Unknown function Q86Y26 256646 15q14 human S1031-p 13165100 LASKLSLsPREHPLS NUT intracellular localization 17934517 1 0 0 nuclear-cytoplasmic shuttling -MAPKAPK5 MAPKAPK5 EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, CAMK; Protein kinase, Ser/Thr (non-receptor); Tumor suppressor Q8IW41 8550 12q24.12-q24.13 human S115-p 18704700 GELFHRIsQHRHFTE Pkinase intracellular localization cytoskeletal reorganization 20734105 2 0 0 S115D mutant causes F-actin rearrangments; S115A mutant reduced the ability of MAPKAPK5 to activate p53-mediated transcription -H2AX H2AX DNA repair, damage; DNA-binding; Helicase P16104 3014 11q23.3 human K36-ac 14791501 RVHRLLRkGHYAERV Histone DNA repair, induced 20488183 2 1 0 -SRC Src EC 2.7.10.2; KINASE; Kinase, protein; Oncoprotein; Protein kinase, TK; Protein kinase, tyrosine (non-receptor) P12931 6714 20q11.23 human S97-p 448232 VALYDYEsRTETDLS SH3_1 enzymatic activity, inhibited 1713455 1 0 0 -RCC2 TD-60 GEF; GEF, misc.; Nucleolus Q9P258 55920 1p36.13 human K293-m1 58123006 LGHNSDGkFIARAQR RCC1 molecular association, regulation L3MBTL iso4(INDUCES) 23583077 0 1 0 -PRC1 PRC1 Cell cycle regulation; Cytoskeletal; Microtubule-binding; Motility/polarity/chemotaxis O43663 9055 15q26.1 human T470-p 471795 LYGSAPRtPSKRRGL MAP65_ASE1 activity, induced; intracellular localization cell cycle regulation; cytoskeletal reorganization PRC1(INDUCES) 16603632; 17438553; 17512944; 27551054 4 12 54 recruitment to the anaphase spindle -CD274 PD-L1 Membrane protein, integral Q9NZQ7 29126 9p24.1 human K178-ub 1883389001 DHQVLSGkTTTTNSK ubiquitination 36376293 1 1 0 -CDC25B CDC25B EC 3.1.3.48; Motility/polarity/chemotaxis; Nuclear receptor co-regulator; PHOSPHATASE; Protein phosphatase, dual-specificity P30305 994 20p13 human S169-p 455885 VLRNITNsQAPDGRR M-inducer_phosp molecular association, regulation; enzymatic activity, induced 14-3-3 sigma(DISRUPTS); 14-3-3 beta(DISRUPTS); 14-3-3 epsilon(DISRUPTS) 21558810 3 0 3 -Il17rb IL17RB Membrane protein, integral Q9JIP3 50905 14 B|14 18.39 cM mouse Y444-p 5756439 LHKYLVVyLGGADLK SEFIR molecular association, regulation STAT5A(INDUCES) 25821217 2 0 0 -Yap1 YAP1 Oncoprotein; Transcription, coactivator/corepressor P46938 22601 9|9 A1 mouse S79-p 3253276 RLRKLPDsFFKPPEP molecular association, regulation transcription, induced TEAD1(INDUCES) 21376238 8 3 3 -Ache AChE EC 3.1.1.7; Hydrolase; Lipid Metabolism - glycerophospholipid; Membrane protein, GPI anchor P21836 11423 5 G2|5 76.32 cM mouse S234-p 54266100 SVTLFGEsAGAASVG COesterase protein conformation 26879641 1 0 0 single mutant (Y337A) mAChE gives more conformational flexibility to approach the drug molecule towards the phosphorylated conjugate without facing several steric constraints at the active-site of the enzyme. -Sh2b1 SH2-B-beta Adaptor/scaffold Q62985 89817 1q36 rat S161-p 21336502 SLRSVGRsVRGSVRG intracellular localization cell motility, induced 23444381 2 0 2 disrupt localization at the plasma membrane.; macrophage migration -Elavl4 ELAVL4 RNA-binding Q61701 15572 4 C7|4 51.42 cM mouse T165-p 40248601 SQYGRIItSRILVDQ RRM_1 intracellular localization translation, induced 25692578 1 0 0 ELAVL4 transport to dendrites -CD274 PD-L1 Membrane protein, integral Q9NZQ7 29126 9p24.1 human K263-ac 1875250200 TFIFRLRkGRMMDVK intracellular localization transcription, inhibited KPNA1(DISRUPTS); HIP1R(DISRUPTS) 32839551 1 1 0 nuclear localization that governs immune-response gene expression -HSPB1 HSP27 Chaperone; Heat shock protein; Motility/polarity/chemotaxis; SUMO LIGASE; SUMO ligase Q00649 chicken S77-p 448402 SPYGRALsELSSGIS protein conformation 12429504 40 25 30 Mutations mimicking phosphorylation of sites single (S15D) and in combination form high and low molecular oligomers and affect chaperone activity in vitro. -RAN RAN Cell cycle regulation; G protein; G protein, monomeric; G protein, monomeric, Ran; Motility/polarity/chemotaxis; Nuclear export; Nuclear receptor co-regulator P62826 5901 12q24.33 human K134-ac 36958832 KDRKVKAkSIVFHRK Ras molecular association, regulation cell cycle regulation RCC1(INDUCES); RANGRF(DISRUPTS) 29040603 1 2 0 regulates chromosome segregation -Prkd1 PRKD1 Autophagy; EC 2.7.11.13; KINASE; Kinase, protein; Motility/polarity/chemotaxis; Protein kinase, CAMK; Protein kinase, Ser/Thr (non-receptor) Q62101 18760 12|12 B3 mouse S744-p 448589 ARIIGEKsFRRSVVG Pkinase activity, induced; enzymatic activity, induced 10473617; 10867018; 12407104; 15084589; 15590638; 15623513; 34478715; 9765302 58 14 20 -PER1 PER1 Transcription factor O15534 5187 17p13.1 human S714-p 465536 ALANKAEsVVSVTSQ protein stabilization; intracellular localization 24857656 2 0 0 contribute to accelerate clock; accelerated degradation of the phosphorylation de?cient PER1 S214G mutant, more rapid nuclear import -ATP7B ATP7B EC 3.6.3.54; Hydrolase; Membrane protein, integral; Membrane protein, multi-pass; Transporter; Transporter, ion channel; Vesicle P35670 540 13q14.3 human S1453-p 11267005 DDDGDKWsLLLNGRD protein stabilization; intracellular localization 21189263 1 5 2 protein trafficking -Slc1a2 GLT1 Membrane protein, integral; Membrane protein, multi-pass; Transporter; Transporter, SLC family P31596 29482 3q32 rat S486-p 3053600 SVNVVGDsFGAGIVY SDF intracellular localization 12324450 1 0 0 -POLB POLB DNA repair, damage; DNA replication; EC 2.7.7.7; Lyase; Transferase P06746 5423 8p11.21 human K81-ub 12486800 DEFLATGkLRKLEKI protein degradation DNA repair, inhibited 19713937 1 3 0 -Adora3 ADORA3 GPCR, family 1; Membrane protein, integral; Membrane protein, multi-pass; Receptor, GPCR P28647 25370 2q34 rat T318-p 450329 LDSNLEQtTE_____ receptor desensitization, altered 10692494 1 0 0 -Srebf1 SREBP-1 iso1 DNA-binding; Membrane protein, integral; Membrane protein, multi-pass; Transcription factor P56720-1 78968 10q22 rat K98-sm 2715401 FSPGPGIkEEPVPLT sumoylation; protein degradation; ubiquitination transcription, inhibited 24379443 3 1 0 -TNNI3 TNNI3 Actin-binding; Motility/polarity/chemotaxis; Motor P19429 7137 19q13.42 human T129-p 6796400 ITEIADLtQKIFDLR Troponin molecular association, regulation; protein conformation C16orf82(INDUCES); TNC(INDUCES) 18986304 1 0 0 -TFEB TFEB DNA-binding; Transcription factor P19484 7942 6p21.1 human S467-p 4785142 KASSRRSsFSMEEGD DUF3371 intracellular localization apoptosis, inhibited 29689560 4 20 2 protects dopaminergic neurons under MPTP-induced oxidative stress ; nuclear translocation -GLI3 GLI3 C2H2-type zinc finger protein; Transcription factor P10071 2737 7p14.1 human S980-p 25780315 VHAPRRCsDGGAHGY protein processing transcription, inhibited 10693759 1 2 1 -Hand1 HAND1 Cell development/differentiation; DNA-binding; Nucleolus; Transcription factor Q64279 15110 11 B1.3|11 35.27 cM mouse T107-p 12518701 PKKERRRtESINSAF HLH intracellular localization; protein conformation cell differentiation, altered 17891141 1 0 0 release from nucleolus, dimerization -Adam17 TACE EC 3.4.24.86; Membrane protein, integral; Motility/polarity/chemotaxis; Protease Q9Z1K9 57027 6q16 rat S811-p 27457932 TRSEKAAsFKLQRQS exocytosis, induced 25232008 2 3 0 -MAP4K4 HGK EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, STE; Protein kinase, Ser/Thr (non-receptor) O95819 9448 2q11.2 human T187-p 480118 RTVGRRNtFIGTPYW Pkinase enzymatic activity, induced carcinogenesis, induced; cell growth, induced; cell adhesion, inhibited 12612079 1 10 102 increased networks of invading cells -RAF1 RAF1 EC 2.7.11.1; KINASE; Kinase, protein; Oncoprotein; Protein kinase, Ser/Thr (non-receptor); Protein kinase, TKL P04049 5894 3p25.2 human S301-p 455219 SSSPNNLsPTGWSQP molecular association, regulation; intracellular localization; enzymatic activity, inhibited; enzymatic activity, induced HRas(DISRUPTS) 15642359; 15664191; 16407412 5 25 65 phosphorylation of S289, S296, and S301 sustains and increases kinase activity -PLCG1 PLCG1 Carbohydrate Metabolism - inositol phosphate; EC 3.1.4.11; Motility/polarity/chemotaxis; Phospholipase P19174 5335 20q12 human S1248-p 448665 HGRAREGsFESRYQQ enzymatic activity, inhibited 21840932 4 33 235 -CAT Catalase Amino Acid Metabolism - tryptophan; Apoptosis; EC 1.11.1.6; Endoplasmic reticulum; Energy Metabolism - methane; Hydrolase; Mitochondrial; Oxidoreductase P04040 847 11p13 human Y231-p 450444 NANGEAVyCKFHYKT Catalase enzymatic activity, induced 12777400 2 9 310 -Pparg PPAR-gamma DNA-binding; Nuclear receptor; Transcription factor P37238 19016 6 E3|6 53.41 cM mouse K268-ac 25780500 ARAILTGkTTDKSPF protein degradation; acetylation; molecular association, regulation N-CoR1(INDUCES) 22863012; 36394167 4 1 0 Impairs adipose plasticity During metabolic adaptions, mediates the diurnal cycle of adipose metabolism by destabilizing BMAL, rhythmicity in glucose tolerance and insulin sensitivity; deacetylation mediates TZD-induced browning of white adipocytes enhancing expression of BAT genes -PPIA PPIA Cyclophilin; EC 5.2.1.8; Isomerase; RNA-binding P62937 5478 7p13 human K125-ac 466190 KTEWLDGkHVVFGKV Pro_isomerase exocytosis, induced; cell adhesion, induced; signaling pathway regulation 24293519 2 9 62 secretion in VSMC, regulates VSMC activation pathway -LBR LBR DNA-binding; Membrane protein, integral; Membrane protein, multi-pass G1N806 turkey S78-p 18911472 SPSRRSRsRSRSRSP molecular association, regulation; protein conformation H3(INDUCES) 22056509 2 6 4 -Nfkbia IkB-alpha DNA-binding; Inhibitor Q9Z1E3 18035 12|12 C1 mouse S32-p 448203 LVDDRHDsGLDSMKD protein degradation carcinogenesis, inhibited; apoptosis, induced; cell growth, inhibited; transcription, induced 10497169; 12070292; 22633953; 34145038; 35637461; 36309088 161 3 17 -TAB2 TAB2 Adaptor/scaffold Q9NYJ8 23118 6q25.1 human S423-p 456007 SAASRNMsGQVSMGP molecular association, regulation; intracellular localization ER-alpha(INDUCES) 12150997; 27992601 2 0 0 -MAP3K11 MLK3 EC 2.7.11.25; KINASE; Kinase, protein; Protein kinase, Ser/Thr (non-receptor); Protein kinase, TKL Q16584 4296 11q13.1 human S674-p 448790 PGRERGEsPTTPPTP activity, inhibited carcinogenesis, induced; apoptosis, inhibited 12458207; 26152725 4 0 0 -TP53BP1 53BP1 DNA repair, damage; Transcription, coactivator/corepressor Q12888 7158 15q15.3 human T302-p 460977 PEPEVLStQEDLFDQ molecular association, regulation DNA repair, induced RIF1(INDUCES) 31390554 2 8 12 regulates Rif1 localization -C5AR1 C5aR GPCR, family 1; Membrane protein, integral; Membrane protein, multi-pass; Receptor, GPCR P21730 728 19q13.32 human S314-p 450055 FQGRLRKsLPSLLRN molecular association, regulation ARRB1(INDUCES); ARRB2(INDUCES) 12464600 2 1 0 -Bcl2l11 BIM Apoptosis O54918 12125 2|2 F1 mouse S55-p 454235 GDRCPHGsPQGPLAP protein degradation; molecular association, regulation apoptosis, altered; apoptosis, inhibited BAX(DISRUPTS) 15486085; 17105963; 18498746 7 1 0 -Adcy6 ADCY6 Adenylyl cyclase; EC 4.6.1.1; Lyase; Membrane protein, integral; Membrane protein, multi-pass; Nucleotide Metabolism - purine; Transporter; Transporter, aquaporin family AAA40678 25289 7q36 rat T931-p 455530 HAQQVEStARLDFLW enzymatic activity, inhibited 11877398 1 0 0 -Gria1 GluR1 Channel, calcium; Channel, ligand-gated; Membrane protein, integral; Membrane protein, multi-pass P19490 50592 10q22 rat K840-ac 206219722 RSESKRMkGFCLIPQ protein stabilization; ubiquitination; receptor internalization, inhibited neural plasticity 28793258 1 0 0 inhibits ubiquitination; impaired learning and memory -cdc25c-b CDC25C EC 3.1.3.48; Motility/polarity/chemotaxis; PHOSPHATASE; Protein phosphatase, dual-specificity P30309 398119 frog T48-p 448419 FSPEQPLtPVTDLAV molecular association, regulation cell cycle regulation CKS1(INDUCES); PIN1(INDUCES) 11013245 7 10 15 Pin1 and CKS1 compete for binding to phosphorylated T48 Cdc25C. -POU5F1 Oct4 DNA-binding; Transcription factor Q01860 5460 6p21.33 human S12-p 18496900 LASDFAFsPPPGGGG protein stabilization; molecular association, regulation transcription, altered PIN1(INDUCES) 21296877 2 0 0 -CTNNAL1 CTNNAL1 Adaptor/scaffold Q9UBT7 8727 9q31.3 human Y534-p 3701811 EGRRGEKyGYLSLPK intracellular localization 17952117 1 3 4 mutantsand wild-type were localized throughout the cytoplasm, and partially associated with the plasma membrane -Esr2 ER-beta DNA-binding; Nuclear receptor O08537 13983 12 C3|12 33.52 cM mouse Y488-p 450057 CKNVVPVyDLLLEML transcription, induced 9500442 3 1 0 -Slc24a2 SLC24A2 Membrane protein, integral; Membrane protein, multi-pass; Transporter; Transporter, SLC family O54701 84550 5q32 rat S504-p 471068 PDVRKPAsKKFFPIT activity, induced 17038313 1 0 0 Mutation to alanine of T476 and either T166 or S504 (or possibly both) eliminates PDBu-induced enhancement (PIE) on the Na(+)/Ca(2+)+K(+) exchanger. -Myod1 MyoD DNA-binding; RNA splicing; Transcription factor P10085 17927 7 B3|7 30.03 cM mouse S5-p 470072 ___MELLsPPLRDID protein degradation; molecular association, regulation; intracellular localization cell cycle regulation; transcription, altered HDAC1(INDUCES); PCAF(DISRUPTS) DNA(DISRUPTS) 14749395; 17014844 3 0 0 -ALK ALK EC 2.7.10.1; KINASE; Kinase, protein; Membrane protein, integral; Oncoprotein; Protein kinase, TK; Protein kinase, tyrosine (receptor) Q9UM73 238 2p23.2-p23.1 human Y1604-p 447828 TAPGAGHyEDTILKS molecular association, regulation; intracellular localization; phosphorylation; enzymatic activity, induced cell cycle regulation; carcinogenesis, induced; cell growth, induced PLCG1(INDUCES) 34270745; 35411036; 9819383 11 5 53 induces phosphorylation of downstream targets, ERK, AKT, STAT3; The complex formation leads to the tyrosine phosphorylation and activation of PLC-gamma. -Foxo4 FOXO4 DNA-binding; Oncoprotein; Transcription factor Q9WVH3 54601 X D|X 43.89 cM mouse K186-ac 459042 MLNPDGGkGGKAPRR Forkhead transcription, inhibited 16012755 2 0 0 -XRCC6 Ku70 DNA repair, damage; DNA-binding; EC 3.6.4.-; EC 4.2.99.-; Helicase; Nuclear receptor co-regulator; RNA-binding P12956 2547 22q13.2 human S77-p 1875071706 VYISKIIsSDRDLLA Ku_N molecular association, regulation; acetylation; intracellular localization DNA repair, inhibited; transcription, inhibited 14-3-3 beta(INDUCES); SIRT1(DISRUPTS) DNA(DISRUPTS) 34635772 1 1 0 -Irf8 IRF8 DNA-binding; Transcription factor P23611 15900 8 E1|8 70.05 cM mouse K310-sm 27490406 VCKGRPNkLERDEVV IRF-3 molecular association, regulation cell differentiation, induced; transcription, inhibited DNA(DISRUPTS) 22942423; 27137933; 32049023 3 0 0 osteoclastogenesis -RASGRF1 RASGRF1 GEF; GEF, Ras Q13972 5923 15q25.1 human S927-p 448487 KEKYRRMsLASAGFP activity, induced 10601308 3 0 0 necessary but not sufficient for RasGRF1 activation -SQSTM1 SQSTM1 Autophagy; Nuclear receptor co-regulator; Ubiquitin conjugating system Q13501 8878 5q35.3 human S407-p 40253303 QMLSMGFsDEGGWLT UBA_5 molecular association, regulation autophagy, induced ubiquitin(INDUCES) 27846364; 29147513; 33084718 3 2 0 binding K63 diubiquitin ; required for inclusion formation by ubiquitinated proteins -KCNA2 Kv1.2 Channel, potassium; Membrane protein, integral; Membrane protein, multi-pass P16389 3737 1p13.3 human Y132-p 452037 MFREDEGyIKEEERP activity, inhibited 15215309; 23769686 3 0 0 this site is required for channel suppression and channel endocytosis; gintonin inhibits Kv1.2 channel activity -VIM Vimentin Cytoskeletal; Motility/polarity/chemotaxis P08670 7431 10p13 human K445-sm 55461976 SKRTLLIkTVETRDG cell motility, induced; cytoskeletal reorganization; cell growth, altered 32047143 1 3 0 increases its solubility -Pdgfrb PDGFRB EC 2.7.10.1; KINASE; Kinase, protein; Membrane protein, integral; Oncoprotein; Protein kinase, TK; Protein kinase, tyrosine (receptor) Q05030 rat Y1020-p 447523 PNETDNDyIIPLPDP enzymatic activity, induced cell cycle regulation; cell growth, induced; signaling pathway regulation 23776396 21 0 0 downstream signaling pathway phosphorylation of STAT3, ERK1/2, Akt, and PLCG1 was determined in PDGF-stimulated VSMCs -Ppp1r9b Spinophilin Adaptor/scaffold; Protein phosphatase, regulatory subunit Q6R891 217124 11|11 D mouse S94-p 448728 SDRGVRLsLPRASSL cell differentiation, induced; cytoskeletal reorganization 33389417 7 8 1 -HEXIM1 HEXIM1 Motility/polarity/chemotaxis; Transcription factor O94992 10614 17q21.31 human K296-ub 9805703 KEYLELEkCLSRMED HEXIM transcription, inhibited 19617712 1 1 0 -ZBTB16 PLZF C2H2-type zinc finger protein; DNA-binding; Oncoprotein; Transcription, coactivator/corepressor Q05516 7704 11q23.2 human K387-sm 2303903 IQRELFSkLGELAVG cell growth, inhibited; transcription, inhibited 17498654 1 0 0 -LTF LTF EC 3.4.21.-; Protease; Secreted; Secreted, signal peptide P02788 4057 3p21.31 human K423-sm 41400401 GYVYTAGkCGLVPVL Transferrin protein stabilization transcription, inhibited 26090800 1 0 0 -TENT2 PAPD4 EC 2.7.7.19; RNA processing; Transferase Q6PIY7 167153 5q14.1 human S62-p 14160718 QLTYGNVsPIQTSAS molecular association, regulation; enzymatic activity, altered; enzymatic activity, induced RNA stability, altered RNA(INDUCES) 31057087; 34288801 2 6 0 -CLDN1 Claudin-1 Cytoskeletal; Membrane protein, integral; Membrane protein, multi-pass Q5ZMG2 424910 chicken T206-p 460032 YPKNAPStGKDYV__ activity, induced 16500087 1 4 1 critical for proper heart asymmetric positioning in the chicken embryo -Osbpl3 OSBPL3 iso3 Endoplasmic reticulum D3Z194 71720 6|6 B2.3 mouse S264-p 6209027 IQGGAFEsPKKEKRP apoptosis, inhibited 31509750 1 23 4 inhibits insulin secretion -MAP3K11 MLK3 EC 2.7.11.25; KINASE; Kinase, protein; Protein kinase, Ser/Thr (non-receptor); Protein kinase, TKL Q16584 4296 11q13.1 human K264-ub 36324902 DMEHKTLkITDFGLA PK_Tyr_Ser-Thr protein degradation 25204656 1 1 0 -Sod2 SOD2 EC 1.15.1.1; Mitochondrial; Oxidoreductase P09671 20656 17 A1|17 8.75 cM mouse K202-ac 27585061 NVRPDYLkAIWNVIN Sod_Fe_C protein conformation 28433661 0 4 0 mediates pentameric SOD2 deaggregation -Cftr CFTR Channel, chloride; EC 3.6.3.49; Hydrolase; Membrane protein, integral; Membrane protein, multi-pass; Transporter; Transporter, ABC family P26361 12638 6 A2|6 8.1 cM mouse S422-p 3333404 SNGDRKHsSDENNVS protein conformation 19927121 4 3 0 in vitro -PDGFRA PDGFRA EC 2.7.10.1; KINASE; Kinase, protein; Membrane protein, integral; Oncoprotein; Protein kinase, TK; Protein kinase, tyrosine (receptor) P16234 5156 4q12 human Y754-p 448439 ERKEVSKySDIQRSL PK_Tyr_Ser-Thr molecular association, regulation SHP-2(INDUCES) 11896619; 7523122 5 5 32 a 134kDa and a 70kDa protein -SH3KBP1 SH3KBP1 Adaptor/scaffold; Apoptosis; Motility/polarity/chemotaxis Q96B97 30011 Xp22.12 human K598-sm 25336500 FGTEGKPkMEPAASS molecular association, regulation; intracellular localization NPHS1(DISRUPTS) 22203040 1 0 0 -Thra TR-alpha iso2 DNA-binding; Nuclear receptor; Transcription factor P63059-2 81812 rat K389-sm 27490405 ASRFLHMkVECPTEL Hormone_recep transcription, altered 22930759 3 0 0 -Slc2a2 GLUT2 Membrane protein, integral; Membrane protein, multi-pass; Transporter; Transporter, SLC family P12336 25351 2q24 rat S503-p 451346 EFRKKSGsAPPRKAT activity, inhibited 8626492 1 0 0 Phosphorylation reduces the initial rate of 3-O-methyl glucose uptake. -WDR62 WDR62 Adaptor/scaffold O43379 284403 19q13.12 human S33-p 453570 PARRGQSsPPPAPPI cell cycle regulation 25501809; 26713495 2 26 124 WDR62 regulation of the mitotic spindle; microtubule association -Map2k1 MEK1 EC 2.7.12.2; KINASE; Kinase, protein; Protein kinase, STE; Protein kinase, dual-specificity (non-receptor) Q01986 170851 8q24 rat S218-p 448514 VSGQLIDsMANSFVG Pkinase enzymatic activity, induced 8034665; 8157000 124 13 83 -GFI1 GFI1 C2H2-type zinc finger protein; Cell cycle regulation; Cell development/differentiation; Transcription factor Q99684 2672 1p22.1 human S94-p 41452096 EDFWRPPsPSASPAS protein degradation; molecular association, regulation; ubiquitination carcinogenesis, altered; signaling pathway regulation FBXW7(INDUCES) 31289136 1 2 0 -HSPA1A HSP70 Chaperone; Heat shock protein; Motility/polarity/chemotaxis P0DMV8 3303 6p21.33 human T636-p 18010647 GGSGSGPtIEEVD__ protein stabilization; molecular association, regulation carcinogenesis, induced; cell growth, induced HOPX(INDUCES); CHIP(DISRUPTS) 22824801; 35148989 2 8 0 cell proliferation increased -YAP1 YAP1 Oncoprotein; Transcription, coactivator/corepressor P46937 10413 11q22.1 human S400-p 9764918 SRDESTDsGLSMSSY protein degradation; ubiquitination carcinogenesis, inhibited; cell motility, inhibited 36828627 2 8 0 -Cdh5 CDH5 Cell adhesion; Membrane protein, integral; Motility/polarity/chemotaxis P55284 12562 8 D3|8 53.04 cM mouse S665-p 2562900 YDVSVLNsVRGGSTK ubiquitination; intracellular localization 26668327 3 0 0 -RELA NFkB-p65 DNA-binding; Nuclear receptor co-regulator; Transcription factor Q04206 5970 11q13.1 human K310-m1 19006700 KRTYETFkSIMKKSP molecular association, regulation carcinogenesis, induced; cell growth, induced; transcription, induced; signaling pathway regulation GLP-1(INDUCES) 21515635; 28122346 2 1 0 -GATA1 GATA1 DNA-binding; Transcription factor P15976 2623 Xp11.23 human K316-ac 466359 ASGKGKKkRGSSLGG molecular association, regulation transcription, altered DNA(INDUCES) 16888089 2 0 0 -MCU MCU Membrane protein, integral; Membrane protein, multi-pass; Mitochondrial Q8NE86 90550 10q22.1 human S57-p 27259016 TVHQRIAsWQNLGAV activity, induced; intracellular localization cell cycle regulation 30858581 2 0 0 Regulates mitochondrial Ca2+ uptake and mitotic progression -Ppfia1 liprin alpha 1 Cell adhesion; Motility/polarity/chemotaxis B2RXW8 233977 7|7 F5 mouse T700-p 31873705 PPGSGRStPRRVPHS molecular association, regulation; intracellular localization PSD-95(DISRUPTS) 28760951 1 1 0 regulates synaptic plasticity -Scnn1g ENaC-gamma Channel, sodium; Membrane protein, integral; Membrane protein, multi-pass; Transporter, ion channel P37091 24768 1q36 rat K12-ub 486253 EKIKAKIkKNLPVRG receptor recycling, inhibited; protein degradation; intracellular localization 9351815 1 0 0 -PML PML Nucleolus; Oncoprotein; SUMO LIGASE; SUMO conjugating system; SUMO ligase; Transcription factor; Tumor suppressor; Ubiquitin conjugating system P29590 5371 15q24.1 human K65-sm 2793914 QQCQAEAkCPKLLPC protein degradation; molecular association, regulation; ubiquitination; intracellular localization; phosphorylation carcinogenesis, induced; cell differentiation, induced; transcription, induced PIAS1(INDUCES); CK2A1(INDUCES); SUMO1(INDUCES); RNF4(INDUCES) 10779416; 17989716; 18408733; 19106612; 19380586; 22406621; 23542129; 27099310; 9756909 14 2 0 -ERCC6 ERCC6 DNA repair, damage; EC 3.6.1.-; EC 3.6.4.-; Helicase; Transcription regulation Q03468 2074 10q11.23 human S1276-p 31874464 DAIMDGAsPDYVLVE molecular association, regulation; intracellular localization DNA repair, altered BRCA1(INDUCES) 31501894 1 2 0 induces cell survival, recruits BRCA1-C complex to DSBs -Stxbp5 STXBP5 Vesicle Q8K400 78808 10|10 A1 mouse K298-sm 31957310 EPCKPILkVELKTTR LLGL neural plasticity 24614299 2 0 0 -RUNX2 AML3 DNA-binding; Transcription factor Q13950 860 6p21.1 human S312-p 10892802 SYLSQMTsPSIHSTT molecular association, regulation transcription, induced osterix(INDUCES) 19801668; 25122769; 27687725 11 1 0 -LIG1 LIG1 DNA repair, damage; EC 6.5.1.1; Ligase P18858 3978 19q13.33 human K376-ub 21178024 VRAEAAEkGDVGLVA DNA_ligase_A_N protein degradation 27573245 1 3 0 -FHOD1 FHOD1 Actin-binding Q9Y613 29109 16q22.1 human Y99-p 31010701 REMLEGFyEEISKGR Formin_GBD_N activity, induced; intracellular localization cell motility, induced; cell adhesion, induced; cytoskeletal reorganization 24331927 1 0 0 induce actin polymerization -THBS1 THBS1 Inhibitor; Motility/polarity/chemotaxis P07996 7057 15q14 human K173-ub 52490406 QLYIDCEkMENAELD protein degradation 26676607 0 1 0 -ELK4 ELK4 DNA-binding; Transcription, coactivator/corepressor P28324 2005 1q32.1 human S387-p 4317601 LSPVAPLsPARLQGA cell growth, induced; transcription, induced 26028036; 9130707 3 0 0 -Nfe2l2 NRF2 DNA-binding; Transcription factor Q60795 18024 2 C3|2 44.75 cM mouse S335-p 18258505 MEFNDSDsGISLNTS protein degradation; molecular association, regulation; activity, inhibited carcinogenesis, induced BTRC(INDUCES) 21245377; 22751928; 22964642; 24892215 4 1 0 -Fcgr2 FCGR2B Cell surface; Membrane protein, integral; Oncoprotein P08101 14130 1 H3|1 78.02 cM mouse Y309-p 448507 EAENTITySLLKHPE activity, induced; phosphorylation 11035084 4 2 1 regulates Ca(2+) influx, ERK activation, SHIP phosphorylation -FMNL2 FMNL2 Cytoskeletal Q96PY5 114793 2q23.3 human S1072-p 1868070803 ARTAKRGsRFFCEPV receptor internalization, induced 31751425 1 0 0 integrin beta 1 internalization -TARDBP TDP-43 RNA-binding Q13148 23435 1p36.22 human T153-p 63083902 GFGFVRFtEYETQVK RRM_1 molecular association, regulation; intracellular localization RNA(DISRUPTS) 28167528 1 0 0 nuclear recruitment, decrease RNA binding affinity (fluorescence-based RNA binding assay, regulation of splicing -Abi1 Abi-1 Adaptor/scaffold; Motility/polarity/chemotaxis Q8CBW3 11308 2 A3|2 15.18 cM mouse Y213-p 449523 PPTVPNDyMTSPARL protein stabilization; molecular association, regulation cell differentiation, inhibited; cytoskeletal reorganization; cell adhesion, altered Abl(INDUCES) 21320496; 32673396 5 42 680 enhances cell adhesion in Bcr-Abl expressing cells; Regulate epiblast differentiation and polarizations; induces the catalytic activity of c-Abl in vitro -Pde3b PDE3B EC 3.1.4.17; Membrane protein, integral; Membrane protein, multi-pass; Nucleotide Metabolism - purine; Phosphodiesterase Q63085 29516 1q34 rat S302-p 449873 GKMFRRPsLPCISRE molecular association, regulation; enzymatic activity, induced 14-3-3 beta(INDUCES) 12453887; 8626720 7 18 27 -IRAK4 IRAK4 EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, Ser/Thr (non-receptor); Protein kinase, TKL Q9NWZ3 51135 12q12 human T345-p 2045325 KFAQTVMtSRIVGTT PK_Tyr_Ser-Thr molecular association, regulation; protein conformation; enzymatic activity, induced IRAK4(DISRUPTS) 17141195; 17161373; 17312103; 25201411 8 4 0 IRAK4 dimerization is inhibited by phosphorylation of this site -Scn2a SCN2A Channel, sodium; Membrane protein, integral; Membrane protein, multi-pass P04775 24766 3q21 rat Y1497-p 1046202 MTEEQKKyYNAMKKL activity, inhibited 17959797 1 0 0 -Gna15 G-alpha 15 G protein; G protein, heterotrimeric; G protein, heterotrimeric alpha G(q) P30678 14676 10 C1|10 39.72 cM mouse S334-p 11380904 QDGGRKGsRARRFFA G-alpha activity, induced 12647293 1 0 0 GNA15 receptor mediated PLC-B activation -Ephb2 EphB2 EC 2.7.10.1; KINASE; Kinase, protein; Membrane protein, integral; Protein kinase, TK; Protein kinase, tyrosine (receptor); Tumor suppressor P54763 13844 4 D3|4 69.0 cM mouse Y602-p 448327 IYIDPFTyEDPNEAV EphA2_TM molecular association, regulation; enzymatic activity, induced cytoskeletal reorganization; cell adhesion, altered NMDAR1(INDUCES); RASA1(INDUCES); Src iso1(INDUCES) 10644995; 10848605; 11136979; 16977320 7 20 120 in vitro -Abcc2 ABCC2 Membrane protein, integral; Membrane protein, multi-pass; Transporter; Transporter, ABC family Q63120 25303 1q54 rat K949-sm 6335600 VEGQKLIkKEFVETG protein stabilization 19074644 1 0 0 siRNA of UBC9 reduces ABCC2 protein expression by 30% -Lipe HSL EC 3.1.1.79; Lipase P15304 25330 1q21 rat S900-p 450193 GNSEPSDsPEMSQSM enzymatic activity, induced 11581251 1 0 0 -CRTC3 TORC3 Transcription, coactivator/corepressor Q6UUV7 64784 15q26.1 human S391-p 3203130 RRRQPPVsPLTLSPG intracellular localization carcinogenesis, induced; transcription, induced 34010639 1 21 33 -Cacng2 Stargazin Channel, calcium; Membrane protein, integral; Membrane protein, multi-pass Q71RJ2 84347 7q34 rat S243-p 455318 RSRSSSRsTEPSHSR molecular association, regulation neural plasticity PSD-95(INDUCES) 25843401 3 0 0 -PSME3 PSME3 Nuclear receptor co-regulator; Protease; Proteasome complex P61289 10197 17q21.31 human K6-sm 25344504 __MASLLkVDQEVKL protein stabilization; intracellular localization; enzymatic activity, induced 21445096 1 0 0 -H3-3A H3F3A DNA-binding P84243 3020 1q42.12 human K9-m1 18545324 RTKQTARkSTGGKAP Histone phosphorylation 16185088 1 2 14 detecting S10 phosphorylation with phospho-antibody was disrupted in dual modified peptides with K9ac and K9 monomethyl as was S28 with K27ac -Hnrnpf hnRNP F RNA splicing; RNA-binding; Spliceosome Q794E4 64200 4q42 rat K87-ac 11320528 HRYIEVFkSHRTEMD protein stabilization RNA splicing, induced 25959059 1 5 0 -Stat5b STAT5B DNA-binding; Oncoprotein; Transcription factor P52632 25126 10q31 rat S730-p 448751 TYMDQAPsPVVCPQA transcription, induced 24489959 14 0 0 -HADHA HADHA ACETYLTRANSFERASE; Acetyltransferase; Amino Acid Metabolism - lysine degradation; Amino Acid Metabolism - tryptophan; Amino Acid Metabolism - valine, leucine and isoleucine degradation; Carbohydrate Metabolism - butanoate; Carbohydrate Metabolism - propanoate; EC 1.1.1.211; EC 4.2.1.17; Lipid Metabolism - fatty acid; Lipid Metabolism - fatty acid elongation in mitochondria; Lipid Metabolism - unsaturated fatty acid biosynthesis; Lyase; Mitochondrial; Other Amino Acids Metabolism - beta-alanine; Oxidoreductase; Secondary Metabolites Metabolism - limonene and pinene degradation P40939 3030 2p23.3 human K350-ac 466489 YHGQVLCkKNKFGAP protein stabilization 27457618 2 7 33 3 sites can be acetylated or ubiquitylated, acetylation blocks ubiquitylation -PAX8 PAX8 Transcription factor Q06710 7849 2q14.1 human S209-p 1877752105 DQDSCRLsIDSQSSS protein stabilization 31391550 1 0 0 -STMN3 STMN3 Cytoskeletal Q9NZ72 50861 20q13.33 human S73-p 454283 PESPMLSsPPKKKDT Stathmin intracellular localization 22577147 2 6 2 -CBX8 CBX8 Transcription, coactivator/corepressor Q9HC52 57332 17q25.3 human S196-p 1874101936 PSSPGDSsKKRGPKP protein degradation cell differentiation, induced; transcription, induced 34253692 1 1 0 -ACVR1 ALK2 EC 2.7.11.30; KINASE; Kinase, protein; Membrane protein, integral; Protein kinase, Ser/Thr (receptor); Protein kinase, TKL Q04771 90 2q24.1 human T203-p 36440209 LPFLVQRtVARQITL TGF_beta_GS enzymatic activity, inhibited 25354296 1 0 0 -F11r JAM-A Cell adhesion; Membrane protein, integral O88792 16456 1 H3|1 79.43 cM mouse Y281-p 458767 APGKKVIySQPSTRS enzymatic activity, inhibited carcinogenesis, altered; cell motility, inhibited 36185363 3 27 902 inhibits Src activity -SLC6A1 SLC6A1 Membrane protein, integral; Membrane protein, multi-pass; Transporter; Transporter, SLC family P30531 6529 3p25.3 human Y107-p 11382801 LECSLGQyTSIGGLG SNF activity, induced; receptor internalization, altered; intracellular localization 11555659 1 0 0 -Nos1 nNOS Amino Acid Metabolism - arginine and proline; EC 1.14.13.39; Oxidoreductase P29476 24598 12q16 rat S847-p 447886 SYKVRFNsVSSYSDS Flavodoxin_1 enzymatic activity, inhibited 10874031; 16984226 11 3 5 -CAPZB CAPZB iso1 Actin-binding; Motility/polarity/chemotaxis P47756-1 832 1p36.13 human T267-p 34732611 RELSQVLtQRQIYIQ protein conformation cytoskeletal reorganization; signaling pathway regulation 30808692 1 0 12 stiffness increased CapZ FRAP dynamics; phosphorylation of this site is modified by binding to phosphatidylinositol 4,5-bisphosphate (PIP2) -KRT19 K19 Cytoskeletal P08727 3880 17q21.2 human S35-p 449970 GVAFRAPsIHGGSGG molecular association, regulation; intracellular localization carcinogenesis, induced; cytoskeletal reorganization HER2(INDUCES) 10212274; 25342465 3 15 115 membrane localization; Phosphorylation fo K19 regulates its 'Subcellular shape- filamentous to granulated morphology'. -TRIM28 TIF1B EC 6.3.2.-; KINASE; Kinase, protein; Ligase; Nuclear receptor co-regulator; Protein kinase, atypical; SUMO LIGASE; SUMO ligase; Transcription, coactivator/corepressor; UBIQUITIN LIGASE; Ubiquitin conjugating system; Ubiquitin ligase Q13263 10155 19q13.43 human K575-sm 3142605 ATEGPETkPVLMALA transcription, inhibited 31391303 2 4 0 loss of TF1B sumoylation induces dsRNA-activated IFN-mediated defenses that rely on RIG-I, MAVS, TBK1, and JAK1 transcription, SUMOylated TIF1B Is required to support efficient virus replication -Cttn Cortactin Actin-binding; Cytoskeletal; Motility/polarity/chemotaxis NP_001385572 60465 1q41-q42 rat T219-p 15418706 GFEYQGKtEKHESQK HS1_rep molecular association, regulation cytoskeletal reorganization; cell motility, inhibited ACTB(DISRUPTS) 30570111 1 1 2 decrease actin bundling, altered higher order structure of dynamin1-cort complex, deformed lamelipodia and short filopodia -Cryaa CRYA1 Chaperone; Heat shock protein P24623 24273 20p12 rat S45-p 452105 PFLSSTIsPYYRQSL Crystallin apoptosis, inhibited 21615407 1 2 0 induces cytoprotection against C2-ceramide and staurosporine induced cell death -Ctnnd2 CTNND2 Actin-binding; Motility/polarity/chemotaxis O35927 18163 15|15 B2 mouse S357-p 4697626 IGTYATLsPTKRLVH molecular association, regulation; intracellular localization cytoskeletal reorganization PSD-95(DISRUPTS); GRIP1(DISRUPTS) 20573893 1 1 0 -SET SET Apoptosis; DNA replication; DNA-binding; Inhibitor; Nuclear receptor co-regulator; Oncoprotein; Protein phosphatase, regulatory subunit Q01105 6418 9q34.11 human K172-ub 15397496 SSKSTEIkWKSGKDL NAP protein degradation 35843886 1 6 1 -Anxa1 ANXA1 Calcium-binding; Lipid-binding P10107 16952 19 B|19 13.83 cM mouse Y21-p 447974 LENQEQEyVQAVKSY sumoylation; ubiquitination 23727357 5 16 171 inhibits ubiquitylation; induces sumoylation at K257 -OPRM1 MOR-1 GPCR, family 1; Membrane protein, integral; Membrane protein, multi-pass; Receptor, GPCR P35372 4988 6q25.2 human S377-p 447784 QNTRDHPsTANTVDR receptor desensitization, induced; receptor internalization, altered signaling pathway regulation 18463167; 21292762; 22375000 24 5 0 inhibitor of PKCE activation; inactivation of MOP receptor -DDX17 DDX17 iso3 EC 3.6.4.13; Helicase; Nuclear receptor co-regulator; Nucleolus; RNA processing; RNA-binding; Spliceosome; Transcription, coactivator/corepressor Q92841-3 10521 22q13.1 human K42-ac 15211508 GERLRKKkWDLSELP protein stabilization; molecular association, regulation cell cycle regulation; apoptosis, inhibited; transcription, induced HDAC3(INDUCES); HDAC1(INDUCES) 20663877 1 1 2 -Atat1 ATAT1 iso2 ACETYLTRANSFERASE; Acetyltransferase; EC 2.3.1.108 Q8K341-2 73242 17|17 B1 mouse K56-ac 27581502 ELGKASAkAQHLPAP Acetyltransf_16 enzymatic activity, induced 23275437 1 1 0 -Itpr1 IP3R1 Channel, calcium; Channel, ligand-gated; Membrane protein, integral; Membrane protein, multi-pass P11881 16438 6 E1|6 49.74 cM mouse S1588-p 450681 RNAARRDsVLAASRD activity, induced; phosphorylation transcription, induced; signaling pathway regulation 17257671; 22495310 10 51 3 induce calcineurin activation, CRTC2 dephosphorylation and activation IP3R1 and gluconeogenesis.; Ca(2+) mobilization -Arhgap12 ARHGAP12 GAP; GAP, Rac/Rho Q8C0D4 75415 18|18 A1 mouse S238-p 451931 PNQGRPDsPVYANLQ SH3-WW_linker cell cycle regulation; cell motility, altered 18515860 0 69 761 -RNF157 RNF157 UBIQUITIN LIGASE; Ubiquitin conjugating system; Ubiquitin ligase Q96PX1 114804 17q25.1 human S661-p 4333533 AQRRRLSsSSLEDSE protein degradation; molecular association, regulation; ubiquitination CDH1(INDUCES) 28655764 1 2 2 -Pip5k1c PIP5K1C Carbohydrate Metabolism - inositol phosphate; EC 2.7.1.68; Kinase, lipid; Motility/polarity/chemotaxis O70161 18717 10|10 C1 mouse Y634-p 486321 DAPSTDIyFPTDERS molecular association, regulation; intracellular localization cell growth, induced; cell motility, induced; cell adhesion, induced; cytoskeletal reorganization PLCG1(DISRUPTS) 17635937; 28388589 3 0 0 focal adhesion assembly, cell migration, and matrix degradation -AKAP11 AKAP11 Adaptor/scaffold; Motility/polarity/chemotaxis Q9UKA4 11215 13q14.11 human T1136-p 40509053 AKEFAPAtPPSTPHN molecular association, regulation; intracellular localization GSK3B(INDUCES) 26088133 1 4 0 AKAP11-GSK3B complexes are present in membrane ruffles. PKA modulates GSK3? binding to AKAP11. -GTF2I GTF2I DNA-binding; Transcription, coactivator/corepressor P78347 2969 7q11.23 human K219-m1 58123202 GGSCGPIkVKTEPTE molecular association, regulation L3MBTL iso4(INDUCES) 23583077 0 1 0 -PTPN3 PTPN3 EC 3.1.3.48; Motility/polarity/chemotaxis; PHOSPHATASE; Protein phosphatase, tyrosine (non-receptor) P26045 5774 9q31.3 human S359-p 451191 PAMRRSLsVEHLETK molecular association, regulation 14-3-3 beta(INDUCES) 9341175 1 23 3 -Vasp VASP Cytoskeletal; Motility/polarity/chemotaxis B5DEX4 361517 1q21 rat T274-p 448381 LARRRKAtQVGEKPP cytoskeletal reorganization; cell motility, inhibited 23203966 11 3 19 -PLK4 PLK4 EC 2.7.11.21; KINASE; Kinase, protein; Nucleolus; Protein kinase, Other; Protein kinase, Ser/Thr (non-receptor) O00444 10733 4q28.1 human S305-p 12122401 SSTSISGsLFDKRRL intracellular localization cell cycle regulation 20032307 4 1 0 enhances centriole amplification -MRE11 MRE11A Cell cycle regulation; DNA repair, damage; DNA-binding; Deoxyribonuclease P49959 4361 11q21 human S558-p 3191332 AEQMANDsDDSISAA protein stabilization; molecular association, regulation PIH1D1(INDUCES) 28436950 1 5 4 -Trpv1 TRPV1 Channel, cation; Membrane protein, integral; Membrane protein, multi-pass; Receptor, misc. Q704Y3 193034 11 B4|11 45.25 cM mouse T371-p 455383 RHLSRKFtEWAYGPV receptor desensitization, altered 16954222 4 0 0 -DUT dUTPase iso2 DNA replication; EC 3.6.1.23; Hydrolase; Mitochondrial; Motility/polarity/chemotaxis; Nuclear receptor co-regulator; Nucleotide Metabolism - pyrimidine P33316-2 1854 15q21.1 human S11-p 451166 SEETPAIsPSKRARP intracellular localization; protein conformation KPNA2(DISRUPTS) 24311590 4 36 11 S11 phosphorylation excludes nuclear entry. -Trpv5 TRPV5 Channel, cation; Membrane protein, integral; Membrane protein, multi-pass; Motility/polarity/chemotaxis Q9XSM3 rabbit S654-p 470109 YVEAFKCsDKEDGQE activity, induced; intracellular localization 18305097; 19157541 3 0 0 CaR-dependent channel activation; inhibits caveolar endocytosis of TRPV5 -Gata1 GATA1 DNA-binding; Transcription factor P17679 14460 X A1.1|X 3.59 cM mouse S178-p 451236 PFFSPTGsPLSSAAY protein degradation; acetylation; molecular association, regulation; ubiquitination; phosphorylation LMO2(INDUCES) DNA(INDUCES) 15167914; 16858405 4 0 0 Phosphorylation and acetylation cause the degradation of acetylated GATA-1; DNA binding is required for MAPK-dependent phosphorylation -TLE1 TLE1 Nuclear receptor co-regulator; Transcription, coactivator/corepressor Q04724 7088 9q21.32 human S289-p 24987529 DASSSPAsTASSASS transcription, induced 24270405 1 2 0 -CREBBP CBP ACETYLTRANSFERASE; Acetyltransferase; DNA-binding; EC 2.3.1.48; Motility/polarity/chemotaxis; Nuclear receptor co-regulator; Transcription, coactivator/corepressor Q92793 1387 16p13.3 human S93-p 20615901 IGNVSASsPVQQGLG molecular association, regulation cell differentiation, inhibited; cell growth, induced CTNNB1(INDUCES) 21751375 1 1 0 -Nlrp3 NLRP3 Inhibitor Q8R4B8 216799 11|11 B1.3 mouse K687-ub 1881229503 GFFHNSPkEEEEERR activity, induced 33893171 1 0 0 inflammasome activation -IFNAR2 IFNAR2 Membrane protein, integral; Receptor, cytokine P48551 3455 21q22.11 human Y316-p 14574796 RKKKVWDyNYDDESD molecular association, regulation transcription, induced; signaling pathway regulation STAT2(DISRUPTS) 34813358 2 0 0 induces STAT phosphorylation and signaling -ALDH1B1 ALDH1B1 Amino Acid Metabolism - arginine and proline; Amino Acid Metabolism - histidine; Amino Acid Metabolism - lysine degradation; Amino Acid Metabolism - tryptophan; Amino Acid Metabolism - valine, leucine and isoleucine degradation; Carbohydrate Metabolism - ascorbate and aldarate; Carbohydrate Metabolism - butanoate; Carbohydrate Metabolism - glycolysis and gluconeogenesis; Carbohydrate Metabolism - propanoate; Carbohydrate Metabolism - pyruvate; EC 1.2.1.3; Lipid Metabolism - fatty acid; Lipid Metabolism - glycerolipid; Mitochondrial; Other Amino Acids Metabolism - beta-alanine; Oxidoreductase; Secondary Metabolites Metabolism - limonene and pinene degradation P30837 219 9p13.1 human K515-ub 1881380903 VTIKVPQkNS_____ molecular association, regulation transcription, inhibited ALDH1B1(DISRUPTS) 34769507 1 0 0 AMBRA1-mediated ubiquitylation of ALDH1B1 inhibitss the self-association of ALDH1B1 and the transcription of PTEN -ARHGAP22 ARHGAP22 GAP; GAP, Rac/Rho Q7Z5H3 58504 10q11.22-q11.23 human S14-p 25795201 RQARRARsKSLVMGE molecular association, regulation 14-3-3 beta(INDUCES) 22952583 1 1 0 -RELA NFkB-p65 DNA-binding; Nuclear receptor co-regulator; Transcription factor Q04206 5970 11q13.1 human K310-ac 459096 KRTYETFkSIMKKSP O-GlcNAc glycosylation; activity, induced; acetylation; protein stabilization; molecular association, regulation; methylation; intracellular localization carcinogenesis, induced; carcinogenesis, inhibited; cell motility, induced; transcription, induced; signaling pathway regulation; transcription, altered; cell growth, induced; apoptosis, inhibited; translation, induced; transcription, inhibited HDAC1(DISRUPTS); ARID4B iso2(DISRUPTS); BRD4(INDUCES) DNA(INDUCES); RNA(INDUCES) 12456660; 15152190; 16926151; 18223231; 18263619; 19103749; 19147572; 19345327; 20064247; 20160011; 20978007; 22205033; 23027940; 23075766; 23224434; 23686307; 24161395; 24189064; 24336331; 24396068; 26200012; 26411366; 27162363; 28416608; 28960214; 29158267; 30670829; 31285272; 32292498; 32416562; 32441762; 33510050; 35265200 84 5 0 -FRS2 FRS2 Adaptor/scaffold Q8WU20 10818 12q15 human Y306-p 449783 PSVNKLVyENINGLS molecular association, regulation cell differentiation, induced SOS1(INDUCES); GRB2(INDUCES) 11278583 3 14 216 -PIAS1 PIAS1 EC 6.3.2.-; Nuclear receptor co-regulator; SUMO LIGASE; SUMO conjugating system; SUMO ligase; Transcription, coactivator/corepressor O75925 8554 15q23 human S466-p 4700782 VIDLTIDsSSDEEEE molecular association, regulation transcription, inhibited SUMO2(INDUCES); SUMO1(INDUCES); UBC9(INDUCES) 19217413; 24174529 2 8 0 -MYLK smMLCK EC 2.7.11.18; KINASE; Kinase, protein; Protein kinase, CAMK; Protein kinase, Ser/Thr (non-receptor) Q15746 4638 3q21.1 human K608-ac 10769105 HEKKSSRkSEYLLPV enzymatic activity, inhibited carcinogenesis, inhibited; cell motility, inhibited 19826488 1 0 0 -MDM4 MDM4 EC 6.3.2.-; Ligase; UBIQUITIN LIGASE; Ubiquitin conjugating system; Ubiquitin ligase O15151 4194 1q32.1 human Y55-p 6039501 TVKEVMHyLGQYIMV SWIB molecular association, regulation; protein conformation 53BP1(INDUCES) 29348869 2 1 0 -Hdac7 HDAC7 DEACETYLASE; Deacetylase; EC 3.5.1.98; Hydrolase Q8C2B3 56233 15|15 F1 mouse S344-p 455621 RPLNRTRsEPLPPSA molecular association, regulation 14-3-3 epsilon(DISRUPTS) 16956611 5 16 18 -GAB2 GAB2 Adaptor/scaffold Q9UQC2 9846 11q14.1 human Y452-p 448384 STNSEDNyVPMNPGS molecular association, regulation PIK3R1(INDUCES) 11334882 6 3 29 -FOXM1 FOXM1 DNA-binding; Transcription factor Q08050 2305 12p13.33 human T611-p 451437 ETLPISStPSKSVLP molecular association, regulation; protein stabilization cell cycle regulation; transcription, induced CDC25A(INDUCES) 22094256; 23240008 4 3 3 -DNM1L DRP1 Apoptosis; EC 3.6.5.5; Endoplasmic reticulum; Hydrolase; Microtubule-binding; Mitochondrial; Motor O00429 10059 12p11.21 human K597-sm 9859925 RGMLKTSkAEELLAE activity, induced; intracellular localization 19638400 1 0 0 sumoylation is linked to its GTPase activity cycle, and influenced by DRP1 localization -NFATC4 NFAT3 DNA-binding; Transcription factor Q14934 4776 14q12 human S281-p 13419502 SGTPSSAsPALSRRG transcription, altered 17213202 1 1 2 -Oprk1 KOR-1 GPCR, family 1; Membrane protein, integral; Membrane protein, multi-pass; Receptor, GPCR P33534 18387 1 A1|1 1.89 cM mouse T357-p 52467201 MRMERQStNRVRNTV receptor internalization, induced; intracellular localization 26635353; 28893975 2 1 0 -Pdk1 PDHK1 EC 2.7.11.2; KINASE; Kinase, protein; Mitochondrial; Protein kinase, Ser/Thr (non-receptor); Protein kinase, atypical Q8BFP9 228026 2|2 C3 mouse Y242-p 465268 RRLCDLYyVNSPELE cell growth, induced 22195962 1 1 1 Y to F mutants show decreased proliferation under hypoxia and increased oxidative phosphorylation. -Srr SRR Amino Acid Metabolism - glycine, serine and threonine; EC 4.3.1.17; EC 4.3.1.18; EC 5.1.1.18; Isomerase Q9QZX7 27364 11|11 B5 mouse T71-p 14701400 IRGLIPDtPEEKPKA PALP enzymatic activity, induced 20493854 1 4 0 -ULK1 ULK1 Autophagy; EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, Other; Protein kinase, Ser/Thr (non-receptor) O75385 8408 12q24.33 human S1042-p 10428809 LCIERRLsALLTGIC DUF3543 protein degradation; molecular association, regulation autophagy, inhibited KLHL20(INDUCES) 26687681 1 3 0 -Spi1 PU.1 DNA-binding; Oncoprotein; Transcription factor P17433 20375 2 E1|2 50.44 cM mouse S41-p 13421401 DYYSFVGsDGESHSD RNA splicing, altered; transcription, altered 20190819 2 0 0 -Foxo3 FOXO3A Autophagy; DNA-binding; Oncoprotein; Transcription factor Q9WVH4 56484 10 B2|10 22.79 cM mouse S320-p 453424 NSNASTVsGRLSPIL intracellular localization cell cycle regulation; transcription, inhibited 12857750; 33530926 9 0 0 -HNRNPUL1 E1B-AP5 RNA splicing; RNA-binding Q9BUJ2 11100 19q13.2 human R618-m2 9481290 NRGGGGFrGRGGGGG molecular association, regulation; intracellular localization NBS1(INDUCES) 26020839 1 3 1 ecruitment at sites of damage -RPL11 RPL11 Motility/polarity/chemotaxis; Nucleolus; Ribosomal; Translation P62913 6135 1p36.11 human K169-ne 12067605 AMRWFQQkYDGIILP protein stabilization; intracellular localization 19713960 1 0 0 -PLEKHG6 PLEKHG6 GEF; GEF, Rac/Rho Q3KR16 55200 12p13.31 human T544-p 31834908 SPSTRPStPSLEGSQ molecular association, regulation; intracellular localization cell cycle regulation PLEKHG6(DISRUPTS); PLK1(INDUCES); RHOA(INDUCES) 24482237; 25336641 2 0 0 -SYK Syk EC 2.7.10.2; KINASE; Kinase, protein; Protein kinase, TK; Protein kinase, tyrosine (non-receptor) P43405 6850 9q22.2 human Y629-p 3656843 VELRLRNyYYDVVN_ enzymatic activity, altered transcription, altered 9624129 2 1 1 -GNG12 G-gamma 12 G protein; G protein, heterotrimeric; G protein, heterotrimeric gamma Q28024 286850 cow S3-p 447877 _____MSsKTASTNN cell adhesion, altered 11099498 1 1 0 -SMPD3 SMPD3 EC 3.1.4.12; Lipid Metabolism - sphingolipid; Membrane protein, integral; Phospholipase Q9NY59 55512 16q22.1 human S209-p 17547980 GSIKRTAsVEYKGDG protein stabilization 36261549 2 5 2 phosphorylation of SMPD3 S208 inhibits degradation of K103-mediated degradation of SMPD3 -Rps6kb1 p70S6K EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, AGC; Protein kinase, Ser/Thr (non-receptor); Translation Q8BSK8 72508 11|11 C mouse K508-ac 32640200 PNSGPYKkQAFPMIS cell growth, induced 27345368 3 0 0 -SYMPK Symplekin Motility/polarity/chemotaxis; RNA processing Q92797 8189 19q13.32 human K483-sm 2586341 PKEEKVVkTESVLIK RNA splicing, altered; cell growth, induced 17923699 1 1 0 regulation of mRNA 3'-end processing- cleavage and polyadenylation -H3C1 H3 DNA-binding P68431 8350 6p22.2 human R2-m2 4145503 ______ArTKQTARK Histone molecular association, regulation PHF21A(DISRUPTS); ING2(DISRUPTS); AIRE(DISRUPTS); RAG2(INDUCES) 20190764 6 0 0 -CFTR CFTR Channel, chloride; EC 3.6.3.49; Hydrolase; Membrane protein, integral; Membrane protein, multi-pass; Transporter; Transporter, ABC family P13569 1080 7q31.2 human S737-p 449981 EPLERRLsLVPDSEQ CFTR_R activity, induced; molecular association, regulation; enzymatic activity, inhibited; protein conformation; activity, inhibited endocytosis, induced CFTR(INDUCES) 11053017; 14602047; 1716180; 19095655; 19328185; 24727471; 26079370 18 9 1 attenuates CFTR-dependent iodide efflux via S737 phosphorylation; inhibits Cl- secretion -SMAD2 SMAD2 DNA-binding; Transcription factor Q15796 4087 18q21.1 human S255-p 448796 ELSPTTLsPVNHSLD activity, induced; protein stabilization; molecular association, regulation; intracellular localization; protein conformation cell differentiation, induced; cell motility, altered; transcription, induced SETD2(INDUCES); SMAD4(INDUCES) RNA(INDUCES) 10197981; 12193595; 19115199; 27153775; 31995604; 34504019 10 0 0 -MCL1 MCL1 Apoptosis; Channel, misc.; Inhibitor; Membrane protein, integral; Mitochondrial Q07820 4170 1q21.2 human S159-p 460683 NNTSTDGsLPSTPPP protein degradation; protein stabilization; molecular association, regulation; ubiquitination cell cycle regulation; carcinogenesis, induced; apoptosis, altered; carcinogenesis, inhibited; cell growth, inhibited; apoptosis, induced; cell growth, induced; apoptosis, inhibited FBXW7(INDUCES); USP9X(INDUCES); RICTOR(INDUCES); JOSD1(DISRUPTS) 16543145; 21368833; 21368834; 25918246; 26205817; 27738316; 28522751; 32081857; 33658484; 34758305; 36535926 17 7 2 -NUAK1 NuaK1 EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, CAMK; Protein kinase, Ser/Thr (non-receptor) O60285 9891 12q23.3 human S600-p 448726 PARQRIRsCVSAENF activity, induced cell motility, altered 12409306; 15060171 4 0 0 -KLF4 KLF4 C2H2-type zinc finger protein; DNA-binding; Transcription factor O43474 9314 9q31.2 human S234-p 31081924 GKFVLKAsLSAPGSE protein stabilization; molecular association, regulation; ubiquitination carcinogenesis, induced TRAF6(INDUCES) 31281496 1 2 0 -RPS6KB2 P70S6KB EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, AGC; Protein kinase, Ser/Thr (non-receptor); Translation Q9UBS0 6199 11q13.2 human S410-p 455989 SFQPKLRsPRRLNSS enzymatic activity, induced 11108720 2 0 3 -CBL CBL Adaptor/scaffold; EC 6.3.2.-; EC 6.3.2.19; Ligase; Motility/polarity/chemotaxis; Oncoprotein; UBIQUITIN LIGASE; Ubiquitin conjugating system; Ubiquitin ligase P22681 867 11q23.3 human S866-p 1868914506 SEIENLMsQGYSYQD UBA protein stabilization; phosphorylation; neddylation cell cycle regulation; DNA repair, induced; cell growth, inhibited; signaling pathway regulation 31315051 1 1 0 enhances TBRII neddylation, stabilization and signaling, induces SMAD2/3 phosphorylation -STK35 CLIK1 EC 2.7.11.1; KINASE; Kinase, protein; Nucleolus; Protein kinase, Other; Protein kinase, Ser/Thr (non-receptor) Q8TDR2 140901 20p13 human S385-p 27446434 KVADFGLsKVCAGLA Pkinase enzymatic activity, induced carcinogenesis, inhibited; cell growth, inhibited 35021089 1 3 0 -Prkcb PKCB iso2 EC 2.7.11.13; KINASE; Kinase, protein; Motility/polarity/chemotaxis; Protein kinase, AGC; Protein kinase, Ser/Thr (non-receptor) P68404-2 18751 7 F2|7 65.75 cM mouse T634-p 448592 ENFDRFFtRHPPVLT Pkinase_C molecular association, regulation; protein conformation; phosphorylation; enzymatic activity, induced PKCB iso2(DISRUPTS) 33850054 2 1 3 induces phosphorylation at S660 -LEO1 LEO1 Transcription regulation Q8WVC0 123169 15q21.2 human S110-p 55377670 DVDQHSGsEAPNDDE molecular association, regulation; intracellular localization carcinogenesis, inhibited; cell growth, inhibited; apoptosis, induced; transcription, inhibited; signaling pathway regulation CTNNB1(DISRUPTS) 30305722 1 2 0 -IL24 IL24 Motility/polarity/chemotaxis; Secreted; Secreted, signal peptide Q13007 11009 1q32.1 human T111-p 41122603 ESCYLVHtLLEFYLK activity, induced; intracellular localization cell cycle regulation; carcinogenesis, inhibited; cell growth, inhibited; cell motility, inhibited; signaling pathway regulation 26009991 1 0 0 IL24 maturation and secretion; activates Caspase-9, PARP, and JNK; inhibits the AKT signaling pathway -KCNQ1 Kv7.1 Channel, potassium; Membrane protein, integral; Membrane protein, multi-pass P51787 3784 11p15.5-p15.4 human T96-p 23120471 PRVSIYStRRPVLAR activity, inhibited 29452158 1 0 1 mediate the inhibition of Ang II on the current -SQSTM1 SQSTM1 Autophagy; Nuclear receptor co-regulator; Ubiquitin conjugating system Q13501 8878 5q35.3 human S349-p 14580829 SSKEVDPsTGELQSL activity, induced; protein stabilization; molecular association, regulation; intracellular localization; protein conformation autophagy, induced; cell growth, induced; apoptosis, inhibited; transcription, induced; autophagy, inhibited; signaling pathway regulation; transcription, inhibited KEAP1(INDUCES) 24886973; 25505069; 27245349; 27846364; 28846113; 30533198; 31444413; 31586112; 32835772; 34405859; 34774801; 34774851; 34838592; 36008391; 36165926; 37306101 48 0 1 regulates the KEAP1-NRF2 pathway.; abolishes oxidative stress through the mTOR/SQSTM1/Keap1/Nrf2 pathway; regulates NRF2 signaling -Snca SNCA Adaptor/scaffold O55042 20617 6 B3|6 29.15 cM mouse T64-p 1876998407 EKTKEQVtNVGGAVV Synuclein molecular association, regulation; intracellular localization transcription, altered SNCA(DISRUPTS) 37252975 1 2 0 -EPHB4 EphB4 EC 2.7.10.1; KINASE; Kinase, protein; Membrane protein, integral; Protein kinase, TK; Protein kinase, tyrosine (receptor) P54760 2050 7q22.1 human Y590-p 450854 IGHGTKVyIDPFTYE EphA2_TM molecular association, regulation; enzymatic activity, induced cell growth, induced RASA1(INDUCES) 11929761; 37507023 2 20 154 -S1PR1 EDG-1 GPCR, family 1; Membrane protein, integral; Membrane protein, multi-pass; Receptor, GPCR P21453 1901 1p21.2 human Y143-p 38535267 LAIAIERyITMLKMK 7tm_1 receptor internalization, induced 25588843 1 0 0 -Fcrl1 FCRL1 Membrane protein, integral Q8R4Y0 229499 3|3 F1 mouse Y281-p 25738355 SRQPEPLyENVNVVS molecular association, regulation; phosphorylation signaling pathway regulation GRB2(INDUCES) 34697226 1 1 3 inhibits ERK phosphorylation; regulates the BCR signaling pathway -RPS6KA6 RSK4 EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, AGC; Protein kinase, Ser/Thr (non-receptor) Q9UK32 27330 Xq21.1 human T581-p 4045800 GENGLLLtPCYTANF Pkinase phosphorylation; enzymatic activity, induced 15632195 1 0 0 phosphorylation of S389 -CACNA1H CACNA1H Cell development/differentiation; Channel, calcium; Membrane protein, integral; Membrane protein, multi-pass O95180 8912 16p13.3 human S1107-p 6729300 LPDSRRGsSSSGDPP activity, inhibited 19131331 2 0 0 -KIF11 KIF11 Microtubule-binding; Motor P52732 3832 10q23.33 human K771-ac 1876332700 KMTFHSQkFCADSDG protein stabilization; ubiquitination; intracellular localization; phosphorylation cell cycle regulation; carcinogenesis, induced; cell growth, induced 35210604 1 0 0 inhibits ubiquitination and primes phosphorylation at T926 -CFTR CFTR Channel, chloride; EC 3.6.3.49; Hydrolase; Membrane protein, integral; Membrane protein, multi-pass; Transporter; Transporter, ABC family P13569 1080 7q31.2 human S712-p 455297 INSIRKFsIVQKTPL CFTR_R molecular association, regulation; enzymatic activity, inhibited CFTR(INDUCES) 14602047 4 6 0 -Abhd5 ABHD5 EC 2.3.1.51; Lipase; Transferase Q9DBL9 67469 9|9 F4 mouse S239-p 36744500 PDFKRKYsSMFEDDT intracellular localization 25421061 2 1 0 PKA-mediated phosphorylation of CGI-58 (ABHD5) leads to CGI-58 dispersion into the cytoplasm. -PKN2 PKN2 EC 2.7.11.13; KINASE; Kinase, protein; Protein kinase, AGC; Protein kinase, Ser/Thr (non-receptor) Q16513 5586 1p22.2 human T958-p 2509079 TSEAPILtPPREPRI Pkinase_C molecular association, regulation; enzymatic activity, inhibited; protein conformation; phosphorylation; enzymatic activity, induced signaling pathway regulation 14-3-3 beta(INDUCES); PDK1(DISRUPTS) 17446865; 19723632; 31451768 3 52 17 mTORC1-mediated nutrient signaling -FOXO3 FOXO3A Autophagy; DNA-binding; Oncoprotein; Transcription factor O43524 2309 6q21 human S626-p 20799905 SLECDMEsIIRSELM FOXO-TAD molecular association, regulation; phosphorylation transcription, induced CBP(INDUCES) 17711846; 22474372 3 1 0 -PDE3A PDE3A EC 3.1.4.17; Membrane protein, integral; Membrane protein, multi-pass; Nucleotide Metabolism - purine; Phosphodiesterase Q14432 5139 12p12.2 human S293-p 471416 FKRRRRSsSVVSAEM molecular association, regulation; enzymatic activity, induced SERCA2(INDUCES); AKAP7(NOT_REPORTED) 25593322 2 2 9 -Grm3 mGluR3 GPCR, family 3; Membrane protein, integral; Membrane protein, multi-pass; Receptor, GPCR P31422 24416 4q12 rat S845-p 450252 RLHLNRFsVSGTATT molecular association, regulation PPPM1A(DISRUPTS) 14663150 1 0 0 -OSBP OSBP Lipid-binding P16258 rabbit S200-p 484803 DESGDEEsVSQTDKT molecular association, regulation; intracellular localization VAPA(INDUCES) 22875984 1 9 1 regulation of Sphingomyelin synthesis. S381A/S3D mutant has enhanced binding and altered localization -PKD2L1 PKD2L1 Channel, cation; Membrane protein, integral; Membrane protein, multi-pass; Motility/polarity/chemotaxis Q9P0L9 9033 10q24.31 human S685-p 394791405 KLGRSIVsSPQGKSG activity, induced 29230552 1 0 0 regulates the channel activity -USP25 USP25 DEUBIQUITINASE; EC 3.4.19.12; Protease; Ubiquitin conjugating system; Ubiquitin-specific protease Q9UHP3 29761 21q21.1 human T680-p 27533602 QPLVGIEtLPPDLRD ubiquitination; enzymatic activity, inhibited 25755282 1 1 0 in vitro deubiquitination assays -Dmbt1 DMBT1 Membrane protein, integral; Oncoprotein; Secreted; Secreted, signal peptide; Tumor suppressor Q60997 12945 7|7 F3 mouse S2082-p 13201903 IDRGQPPsTKL____ molecular association, regulation exocytosis, altered; cytoskeletal reorganization NHERF(INDUCES); ACTB(INDUCES) 15146979 1 0 0 Phosphomimetic peptides associate with the cytoskeleton, though not binding directly to actin. -Lrrk2 LRRK2 EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, Ser/Thr (non-receptor); Protein kinase, TKL Q5S006 66725 15|15 E3 mouse S935-p 4725898 NAQRHSNsLGPVFDH molecular association, regulation; enzymatic activity, inhibited; enzymatic activity, induced; phosphorylation autophagy, induced 14-3-3 beta(INDUCES); 14-3-3 theta(INDUCES); 14-3-3 zeta(INDUCES); 14-3-3 epsilon(INDUCES); 14-3-3 gamma(INDUCES); 14-3-3 eta(INDUCES) 20642453; 20659021; 21390248; 33055242; 34871735; 37454104 43 17 2 -HSP90AA1 HSP90A Chaperone; Heat shock protein P07900 3320 14q32.31 human Y627-p 462281 RDNSTMGyMAAKKHL HSP90 molecular association, regulation PPP5C(DISRUPTS) 22727666 1 8 89 -Dync1i2 DYNC1I2 Microtubule-binding; Motility/polarity/chemotaxis; Motor O88487 13427 2 C2|2 42.38 cM mouse S81-p 449148 PIVPPPMsPSSKSVS cell motility, induced 32554528 2 26 2 regulates dynein function; neuronal migration -MAPT Tau iso3 ACETYLTRANSFERASE; Acetyltransferase; Cytoskeletal P10636-3 4137 17q21.31 human T137-p 449079 KKVAVVRtPPKSPSS molecular association, regulation cytoskeletal reorganization 10747907 149 48 14 regulates association with membrane -PNKP Pnk1 DNA-binding; EC 2.7.1.78; EC 3.1.3.32; Kinase, other; Phosphatase (non-protein) Q96T60 11284 19q13.33 human S114-p 460832 EETRTPEsQPDTPPG molecular association, regulation; enzymatic activity, inhibited; intracellular localization; enzymatic activity, induced DNA repair, induced DNA(INDUCES) 21637298; 21824916 2 18 31 -MCF2 MCF2 Apoptosis; Cell development/differentiation; GEF; GEF, Rac/Rho; Motility/polarity/chemotaxis; Oncoprotein P10911 4168 Xq27.1 human Y510-p 33402206 LIQTERVyVRELYTV RhoGEF activity, induced; molecular association, regulation; intracellular localization cytoskeletal reorganization GRB2(INDUCES); CDC42(INDUCES); RHOA(INDUCES) 24778185 1 0 0 RhoA-GTPases activity induced transcriptional activation of NFkB -SYK Syk EC 2.7.10.2; KINASE; Kinase, protein; Protein kinase, TK; Protein kinase, tyrosine (non-receptor) P43405 6850 9q22.2 human Y323-p 447658 STVSFNPyEPELAPW molecular association, regulation; enzymatic activity, induced Fyn(INDUCES); CBL(INDUCES) 9535867 21 30 1019 -PKM PKM Carbohydrate Metabolism - glycolysis and gluconeogenesis; Carbohydrate Metabolism - pyruvate; EC 2.7.1.40; KINASE; Kinase, other; Mitochondrial; Nucleotide Metabolism - purine P14618 5315 15q23 human K186-ub 12393391 GLISLQVkQKGADFL PK enzymatic activity, inhibited carcinogenesis, inhibited; cell growth, inhibited 26975375 1 3 2 -FOXO3 FOXO3A Autophagy; DNA-binding; Oncoprotein; Transcription factor O43524 2309 6q21 human K290-ac 460596 DSPSQLSkWPGSPTS protein stabilization; molecular association, regulation; ubiquitination; intracellular localization apoptosis, induced; transcription, induced JNK1(INDUCES); SKP2(DISRUPTS) 21841822; 25981116; 27669435 5 0 0 -MEX3B RKHD3 RNA-binding; Ubiquitin conjugating system Q6ZN04 84206 15q25.2 human S462-p 4668104 HLARRVRsDPGGGGL protein stabilization; molecular association, regulation; intracellular localization 14-3-3 eta(INDUCES) 18779327 1 0 0 -CNN1 calponin 1 Actin-binding; Contractile; Motility/polarity/chemotaxis; Myosin-binding Q08092 396911 pig S175-p 450890 MGTNKFAsQQGMTAY Calponin activity, induced 9851593 3 2 0 Phosphorylation of calponin at S175 may play a role in vasoconstriction. -LIG1 LIG1 DNA repair, damage; EC 6.5.1.1; Ligase P18858 3978 19q13.33 human S51-p 468123 GVVSESDsPVKRPGR molecular association, regulation; intracellular localization cell cycle regulation; cytoskeletal reorganization; DNA repair, inhibited; cell growth, altered RFC1(INDUCES); RAD17(DISRUPTS); RFC1(DISRUPTS) 12851383; 19223468; 22952233 3 56 8 S51D mutant induces cellular senescence ; regulates DNA replication and repair -CACNA1C CACNA1C Channel, calcium; Membrane protein, integral; Membrane protein, multi-pass BAA34185.2 guinea pig S1574-p 467228 VACKRLVsMNMPLNS GPHH activity, induced; molecular association, regulation; protein conformation Calmodulin(DISRUPTS) 25209265; 30042022 4 0 0 -TRPV6 TRPV6 Channel, calcium; Membrane protein, integral; Membrane protein, multi-pass Q9H1D0 55503 7q34 human S184-p 12173901 LARRASVsARATGTA Ank_2 activity, inhibited 19805577 1 0 0 involved in regulation of calcium influx by ATP -Gys2 GYS2 Carbohydrate Metabolism - starch and sucrose; Cytoskeletal; EC 2.4.1.11; Transferase P17625 25623 4q44 rat S641-p 7390700 FKYPRPSsVPPSPSG Glycogen_syn phosphorylation 19124463 1 0 0 S641A mutant caused decrease in S645 phosphorylation -DIAPH1 Diaphanous-1 Actin-binding; Adaptor/scaffold; Motility/polarity/chemotaxis O60610 1729 5q31.3 human T768-p 3946102 PVLPFGLtPKKLYKP protein degradation; molecular association, regulation KIF1A(INDUCES); ACTB(INDUCES) 23325789 2 1 0 induces sumoylation; modulates mitochondrial movement -Hmgcs2 HMGCS2 Amino Acid Metabolism - valine, leucine and isoleucine degradation; Carbohydrate Metabolism - butanoate; EC 2.3.3.10; Lipid Metabolism - synthesis and degradation of ketone bodies; Mitochondrial; Secondary Metabolites Metabolism - terpenoid backbone biosynthesis; Transferase P54869 15360 3 F2.2|3 42.74 cM mouse K83-sc 33344864 FNNVEAGkYTVGLGQ HMG_CoA_synt_N enzymatic activity, inhibited 24315375 0 2 0 K83E or K310E mutants lose enzymatic activity -Akt1 Akt1 EC 2.7.11.1; KINASE; Kinase, protein; Oncoprotein; Protein kinase, AGC; Protein kinase, Ser/Thr (non-receptor) P47196 24185 6q32 rat S473-gl 4261200 RPHFPQFsYSASGTA Pkinase_C phosphorylation 18570920 5 0 0 O-GlcNAc modification at Akt S473 competes with phosphorylation at Akt S473 -Gata6 GATA6 Motility/polarity/chemotaxis; Transcription factor Q61169 14465 18 A1|18 5.63 cM mouse S264-p 2833503 ASARFPYsPSPPMAN GATA-N cell differentiation, induced; transcription, induced 29454706 2 3 3 -BCAR1 P130Cas Adaptor/scaffold; Motility/polarity/chemotaxis P56945 9564 16q23.1 human S139-p 483627 GPSPQFQsPPAKQTS intracellular localization cell motility, altered 19454314 1 17 8 -NFE2L2 NRF2 DNA-binding; Transcription factor Q16236 4780 2q31.2 human K554-ac 7106311 DKSLHLLkKQLSTLY bZIP_Maf molecular association, regulation transcription, induced DNA(INDUCES) 19273602 1 1 0 -STAT4 STAT4 DNA-binding; Transcription factor Q14765 6775 2q32.2-q32.3 human K667-ac 1878023503 YLYPDIPkDKAFGKH intracellular localization; phosphorylation cell differentiation, induced JAK2(INDUCES) 35614130 1 1 0 nuclear translocation, required for JAK2-STAT4 complex formation -MTA1 MTA1 Motility/polarity/chemotaxis; Nuclear receptor co-regulator; Transcription, coactivator/corepressor Q13330 9112 14q32.33 human K626-ac 460693 RNLLLNGkSYPTKVR molecular association, regulation; intracellular localization transcription, induced POLR2A(INDUCES) 16617102 2 0 0 MTA1 colocalizes with acetyl-He and interacts with RNA Pol II complex and recruits complex to the BCAS3 enhancer -Pparg PPAR-gamma DNA-binding; Nuclear receptor; Transcription factor P37238 19016 6 E3|6 53.41 cM mouse S273-p 15175800 TGKTTDKsPFVIYDM activity, induced; molecular association, regulation cell differentiation, inhibited; translation, altered; transcription, inhibited; transcription, altered Trap150(INDUCES) 20651683; 25409143; 30008738; 34431242; 34526909; 37230992 26 2 0 -ACAP1 CENTB1 GAP; GAP, ARF; Motility/polarity/chemotaxis Q15027 9744 17p13.1 human S554-p 458238 SIRPRPGsLRSKPEP molecular association, regulation cell motility, altered ITGB1(INDUCES) 16256741 2 2 2 -USP2 USP2 DEUBIQUITINASE; EC 3.4.19.12; Protease; Ubiquitin-specific protease O75604 9099 11q23.3 human S225-p 803501401 SRVPEIIsPTYRPIG molecular association, regulation 29490279 1 1 0 disassociation of phosphorylated R-SMADs from the receptor complex; USP2a promotes TGF-beta-induced EMT and metastasis -Notch3 NOTCH3 Membrane protein, integral Q61982 18131 17 B1|17 17.37 cM mouse K1731-ac 31089504 DSECPEAkRLKVEEP protein degradation; ubiquitination carcinogenesis, inhibited; cell growth, inhibited; transcription, inhibited; signaling pathway regulation 22120716 1 1 0 -E2F1 E2F1 DNA-binding; Transcription factor Q01094 1869 20q11.22 human S375-p 3193946 PVDEDRLsPLVAADS molecular association, regulation; protein conformation cell cycle regulation; transcription, inhibited; transcription, altered; cell growth, altered PRB1(INDUCES) DNA(DISRUPTS) 20616879; 22945643; 37467925 4 13 0 -Brca1 BRCA1 EC 6.3.2.-; Nuclear receptor co-regulator; Transcription, coactivator/corepressor; Tumor suppressor; UBIQUITIN LIGASE; Ubiquitin conjugating system; Ubiquitin ligase P48754 12189 11 65.18 cM|11 D mouse S1152-p 450007 LRRESSRsPSPVTHA molecular association, regulation; ubiquitination; intracellular localization; phosphorylation; enzymatic activity, induced DNA repair, induced; apoptosis, altered SKP2(INDUCES); NBS1(INDUCES) 19996295; 36065181 6 15 6 induces CHK1-S345 and RPA2-S4/8 10 phosphorylation and NBS1 ubiquitination; confers resistance to gamma-radiation by preventing radiation-induced apoptosis; required for proper skin structure and hair regeneration; recruits ATM to DSBs; required for tumor prevention -Stxbp3 STXBP3 Vesicle Q60770 20912 3|3 F3 mouse Y521-p 459181 RQKPRTNyLELDRKN Sec1 molecular association, regulation; intracellular localization exocytosis, induced STX4(DISRUPTS); VAMP2(DISRUPTS) 17916632; 21444687; 21548926; 23937695 5 8 68 GLUT4 vesicle exocytosis induced; Munc18c dissociation from syntaxin 4; 2-deoxy-glucose uptake in adipocytes -Smpd3 SMPD3 EC 3.1.4.12; Lipid Metabolism - sphingolipid; Membrane protein, integral; Phospholipase Q9JJY3 58994 8|8 D3 mouse S208-p 17547980 GSIKRTAsVEYKGDG protein stabilization 22074919; 36261549 2 5 2 phosphorylation of SMPD3 S208 inhibits degradation of K103-mediated degradation of SMPD3 -Zap70 ZAP70 EC 2.7.10.2; KINASE; Kinase, protein; Protein kinase, TK; Protein kinase, tyrosine (non-receptor) P43404 22637 1 B|1 15.41 cM mouse Y290-p 447586 DTLNSDGyTPEPARL signaling pathway regulation 34452999 10 14 447 regulates TCR signaling -Gria1 GluR1 Channel, calcium; Channel, ligand-gated; Membrane protein, integral; Membrane protein, multi-pass P19490 50592 10q22 rat K886-ub 40320201 VVSQDFPkSMQSIPC protein degradation; intracellular localization 25660027 3 0 0 -Nr3c2 MCR DNA-binding; Nuclear receptor Q8VII8 110784 8 C1|8 36.34 cM mouse S837-p 29669801 NEEKMHQsAMYELCQ Hormone_recep molecular association, regulation; intracellular localization transcription, inhibited SRC-1(DISRUPTS) 27422824 3 2 0 decreased nuclear localization -RPTOR Raptor Adaptor/scaffold Q8N122 57521 17q25.3 human S696-p 11315003 EKNYALPsPATTEGG enzymatic activity, induced; phosphorylation 21325048; 22493283 8 11 1 mutation of S696A interferes with the insulin-stimulated phosphorylation of p70S6K; mTORC1 activity induced -RIPK1 RIPK1 EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, Ser/Thr (non-receptor); Protein kinase, TKL Q13546 8737 6p25.2 human S166-p 27116401 LASFKMWsKLNNEEH PK_Tyr_Ser-Thr molecular association, regulation; enzymatic activity, inhibited; enzymatic activity, induced; phosphorylation apoptosis, induced FADD(INDUCES); CASP8(INDUCES) 33469115; 34965934; 35256774; 36356302 36 2 0 -TTK TTK Cancer Testis Antigen (CTA); EC 2.7.12.1; KINASE; Kinase, protein; Protein kinase, Other; Protein kinase, dual-specificity (non-receptor) P33981 7272 6q14.1 human K827-ub 21187456 NSPNSILkAAKTLYE protein degradation cell cycle regulation 34586601 1 3 0 -UIMC1 RAP80 Nuclear receptor co-regulator; Transcription, coactivator/corepressor Q96RL1 51720 5q35.2 human S677-p 453731 TRRDLNEsPVKSFVS cell cycle regulation; DNA repair, altered 23264621 1 32 3 regulates sensitivity to ionizing radiation -Mvk MVK EC 2.7.1.36; Kinase, other; RNA-binding; Secondary Metabolites Metabolism - terpenoid backbone biosynthesis; Translation P17256 rat K345-sm 12723515 GCGITLLkPGLERAK GHMP_kinases_C translation, inhibited 20167237 1 0 0 -SLC9A5 NHE5 Membrane protein, integral; Membrane protein, multi-pass; Transporter; Transporter, SLC family Q14940 6553 16q22.1 human S702-p 20832300 AVILTVEsEEEEEES molecular association, regulation; activity, inhibited endocytosis, induced ARRB1(INDUCES) 21296876 1 0 0 -PRPF19 PRPF19 EC 6.3.2.-; EC 6.3.2.19; Ligase; RNA splicing; Spliceosome; UBIQUITIN LIGASE; Ubiquitin conjugating system; Ubiquitin ligase Q9UMS4 27339 11q12.2 human T193-p 17331800 ERKKRGKtVPEELVK molecular association, regulation; intracellular localization 14-3-3 beta(INDUCES); CDC5L(INDUCES) 20629186 1 0 0 involved in neuronal differentiation -LMNB1 Lamin B1 Cytoskeletal P20700 4001 5q23.2 human S405-p 448733 VTVSRASsSRSVRTT cell cycle regulation 8663071 3 12 94 -SLAMF6 SLAMF6 Membrane protein, integral; Receptor, misc. Q96DU3 114836 1q23.2-q23.3 human Y285-p 457709 SPTNNTVyASVTHSN molecular association, regulation Lck(INDUCES); SH2D1A(INDUCES) 24688028 2 4 188 -Slc2a1 GLUT1 Membrane protein, integral; Membrane protein, multi-pass; Transporter; Transporter, SLC family P17809 20525 4 D2.1|4 55.34 cM mouse T478-p 4148989 GASQSDKtPEELFHP protein degradation; molecular association, regulation; ubiquitination apoptosis, inhibited TRIM21(INDUCES) 35483524 1 12 2 -Nfatc2 NFAT1 DNA-binding; Transcription factor Q60591 18019 2 H3|2 88.91 cM mouse S174-p 447841 LCLSPASsGSSASFI transcription, inhibited 11030334 0 1 0 -ID3 ID3 DNA-binding; Transcription, coactivator/corepressor Q02535 3399 1p36.12 human S18-p 25295708 YEAVCCLsERSLAIA protein stabilization 25090023 1 2 1 regulates vascular EC survival and growth of microvascular lesions -BACH2 BACH2 DNA-binding; Transcription factor Q9BYV9 60468 6q15 human S520-p 53354442 LETRTRTsSSCSSYS intracellular localization transcription, induced 36448459 1 1 0 -LDB1 LDB1 Transcription, coactivator/corepressor Q86U70 8861 10q24.32 human K170-ub 14512104 SMVTQHGkPMFTQVC LIM_bind protein degradation; protein stabilization 20423330 2 0 0 differential regulation of protein expression-mono-ubiquitination promotes stabilization, poly-ubiquitination induces degradation -Grin2b NMDAR2B Channel, calcium; Channel, ligand-gated; Membrane protein, integral; Membrane protein, multi-pass Q00960 24410 4q43 rat S1166-p 481156 SDDFKRDsVSGGGPC NMDAR2_C activity, induced; receptor desensitization, inhibited; receptor inactivation, inhibited 24431445; 24847051 3 2 1 NMDAR potentiation and Ca2+ signaling in spines; enhanced receptor gating -H1-4 H1E DNA-binding P10412 3008 6p22.2 human K26-me 2303905 PVKKKARkSAGAAKR molecular association, regulation HP1 alpha(INDUCES); CBX3(INDUCES); CBX1(INDUCES) 16127177 2 1 0 -DVL2 DVL2 Adaptor/scaffold; Motility/polarity/chemotaxis O14641 1856 17p13.1 human K477-ub 610815806 PERREARkYASGLLK DEP molecular association, regulation; intracellular localization cell motility, induced; signaling pathway regulation Cofilin-1(INDUCES); VANGL1(INDUCES) 31340145 1 3 0 DVL2 variant with all encoded lysine residues mutated to arginine is sufficient to restore WNT activation -NOTCH1 Notch 1 Membrane protein, integral; Motility/polarity/chemotaxis; Oncoprotein; Receptor, misc.; Transcription factor P46531 4851 9q34.3 human K2160-ac 18899502 VQGKKVRkPSSKGLA intracellular localization cell growth, induced; apoptosis, inhibited 28377411 2 1 0 -CERT1 COL4A3BP EC 2.7.11.9; KINASE; Kinase, protein; Lipid-binding; Protein kinase, Ser/Thr (non-receptor); Protein kinase, atypical Q9Y5P4 10087 5q13.3 human S138-p 4777479 GSMVSLVsGASGYSA molecular association, regulation; activity, inhibited 28652409 0 1 0 reduced PtdIns(4)P binding affinity as well as low ceramide transfer activity, E494R/N495K/P535R/E537K mutations, recovery of both PtdIns(4)P binding and ceramide transfer activity. -SETDB1 SETDB1 Amino Acid Metabolism - lysine degradation; EC 2.1.1.43; METHYLTRANSFERASE; Methyltransferase; Methyltransferase, protein lysine Q15047 9869 1q21.3 human K867-ub 56394103 IESVENFkEGYESDA SET methylation; enzymatic activity, induced 27237050; 27798683 3 3 0 induces H3K9 methyltransferase activity -TP73 p73 DNA-binding; Transcription factor; Tumor suppressor O15350 7161 1p36.32 human K321-ac 460605 ALNESSAkNGAASKR molecular association, regulation cell growth, inhibited; apoptosis, induced; transcription, induced DNA(INDUCES) 11804596 1 1 0 induces binding to p53AIP1 gene and induces its transcription, but retains an intact ability to regulate genes. -Brsk2 BRSK2 EC 2.7.11.1; EC 2.7.11.26; KINASE; Kinase, protein; Protein kinase, CAMK; Protein kinase, Ser/Thr (non-receptor) Q69Z98 75770 7|7 F5 mouse S424-p 2085944 ASSGLSTsPLSSPRV protein stabilization; enzymatic activity, inhibited; phosphorylation 23790753 1 17 0 inhibits axon branching (activated in BRSK2 18A mutant) -CSF2RB CSF2RB Membrane protein, integral; Receptor, cytokine P32927 1439 22q12.3 human Y628-p 450121 PPPGSLEyLCLPAGG activity, induced; molecular association, regulation; phosphorylation apoptosis, altered; cell motility, altered; transcription, altered; cell growth, altered GRB2(INDUCES); SHC1(INDUCES); SHP-2(INDUCES) 10329850; 10672044; 10704825; 10760518; 9257712 6 0 0 Phosphorylation of Y628, Y711, or Y766 is necessary and sufficient for STAT activation by IL-5. -PINK1 PINK1 EC 2.7.11.1; KINASE; Kinase, protein; Membrane protein, integral; Mitochondrial; Protein kinase, Other; Protein kinase, Ser/Thr (non-receptor) Q9BXM7 65018 1p36.12 human K433-ub 40212809 RAVIDYSkADAWAVG Pkinase protein stabilization; molecular association, regulation TOM20(INDUCES) 23885119 1 0 0 -SUPT5H SPT5 RNA-binding; Transcription, coactivator/corepressor O00267 6829 19q13.2 human T775-p 458815 TPMYGSQtPMYGSGS transcription, induced; transcription, altered 10757782; 16427012 3 6 38 required for c-fos induction and activation in vivo -SSRP1 SSRP1 Nucleolus; RNA-binding; Transcription initiation complex; Transcription, coactivator/corepressor Q08945 6749 11q12.1 human K143-m1 58123206 VSQCTTGkNEVTLEF SSrecog molecular association, regulation L3MBTL iso4(INDUCES) 23583077 0 1 0 -Rab3il1 RAB3IL1 GEF; GEF, Rab Q99NH3 171452 1q43 rat S169-p 467058 VITSTPAsPNRELHP Sec2p activity, inhibited cell motility, induced; cytoskeletal reorganization 28123016 2 21 35 suppresses RAB3IL1 GEF activity; regulates axonal outgrowth -EPB41 EPB41 iso4 Cytoskeletal P11171-4 2035 1p35.3 human Y13-p 463285 SLLDDTVyECVVEKH FERM_N cytoskeletal reorganization 20206558 1 5 46 -ODF2 ODF2 iso3 Cancer Testis Antigen (CTA); Cytoskeletal Q5BJF6-3 4957 9q34.11 human S796-p 449230 YSTFLTSsPIRSRSP molecular association, regulation cytoskeletal reorganization PLK1(INDUCES) 19386263 1 9 0 -CALD1 Caldesmon Actin-binding P12957 373965 chicken S615-p 2873302 RAEFLNKsAQKSGMK Caldesmon molecular association, regulation ACTB(NOT_REPORTED) 8182108 1 12 0 -Ptprh PTPRH EC 3.1.3.48; Membrane protein, integral; Motility/polarity/chemotaxis; PHOSPHATASE; Receptor protein phosphatase, tyrosine E9Q0N2 545902 7|7 A1 mouse Y953-p 10804386 ENVASLVyENASAIM molecular association, regulation cytoskeletal reorganization GRB2(INDUCES); Fyn(INDUCES) 20398064 1 1 1 -L1cam NCAM-L1 Cell adhesion; Membrane protein, integral Q05695 50687 Xq37 rat Y1178-p 456529 KDETFGEyRSLESDN Bravo_FIGEY molecular association, regulation; intracellular localization Ezrin(DISRUPTS); SNAP-91(DISRUPTS); AP2M1(DISRUPTS) 15911348; 18478542 12 3 10 -XRCC1 XRCC1 DNA repair, damage P18887 7515 19q13.31 human S410-p 3181465 MAGPGSSsEEDEASH molecular association, regulation PARP1(DISRUPTS) 25477519 2 5 0 -Syne1 SYNE1 Actin-binding; Membrane protein, integral; RNA-binding Q6ZWR6 64009 10|10 A1 mouse S1366-p 30310303 SSHERFLsFSSLESL receptor internalization, induced; molecular association, regulation; intracellular localization cytoskeletal reorganization ACTB(INDUCES) 24191017 1 1 0 localization to dendritic spines, GluA2 internalization -SHC1 SHC1 Adaptor/scaffold; Apoptosis; Mitochondrial; Motility/polarity/chemotaxis P29353 6464 1q21.3 human Y350-p 448510 EPPDHQYyNDFPGKE molecular association, regulation apoptosis, altered; apoptosis, inhibited GRB2(INDUCES) 15688026; 8939605; 8947042 29 22 943 -EIF4G1 eIF4G iso8 RNA-binding; Translation; Translation initiation Q04637-8 1981 3q27.1 human S1093-p 3194291 FAPGGRLsWGKGSSG molecular association, regulation; protein conformation transcription, induced; translation, induced; signaling pathway regulation eIF3-alpha(DISRUPTS); eIF3-theta(INDUCES) 30012863; 30012864 2 49 2 PKC-Raf-ERK signaling -DEPTOR DEPTOR Apoptosis Q8TB45 64798 8q24.12 human S235-p 4723788 MELLNEKsPSSQETH protein stabilization; molecular association, regulation; ubiquitination; phosphorylation carcinogenesis, induced USP7(INDUCES) 35216969 2 12 1 -Map1lc3b LC3B Autophagy; Microtubule-binding; Ubiquitin-like modifier; Vesicle Q9CQV6 67443 8|8 E1 mouse T50-p 37045604 QLPVLDKtKFLVPDH ATG8 autophagy, induced 25544559 3 1 0 induces fusion of autophagosomes with lysosomes and autophagy-mediated pathogen clearance -Crebbp CBP ACETYLTRANSFERASE; Acetyltransferase; DNA-binding; EC 2.3.1.48; Motility/polarity/chemotaxis; Nuclear receptor co-regulator; Transcription, coactivator/corepressor P45481 12914 16 A1|16 2.4 cM mouse R624-me 1280604 PAALKDRrMENLVAY KIX molecular association, regulation CREB(DISRUPTS) 11701890 1 0 0 -ABRAXAS2 ABRAXAS2 Ubiquitin conjugating system Q15018 23172 10q26.13 human Y377-p 3196742 EDSDDSDyENLIDPT molecular association, regulation LNK(INDUCES) 30755420 1 4 4 interaction with LNK further regulates LNK interaction with BRISC -Etv4 ETV4 DNA-binding P28322 18612 11 D|11 65.48 cM mouse K95-sm 3144816 HSPTTRIkKEPQSPR ETS_PEA3_N protein degradation; ubiquitination transcription, induced; transcription, inhibited 18447755; 19307308 4 1 0 -DAB2IP DAB2IP GAP; GAP, Ras; Tumor suppressor Q5VWQ8 153090 9q33.2 human S728-p 478274 PSPARSSsYSEANEP DUF3498 molecular association, regulation apoptosis, induced; transcription, altered 14-3-3 beta(INDUCES); ASK1(INDUCES); RIPK1(INDUCES); TRAF2(INDUCES) 17389591 1 1 1 -GRIK1 GluR5 iso2 Channel, ligand-gated; Membrane protein, integral; Membrane protein, multi-pass P39086-2 2897 21q21.3 human S885-p 457627 KSRTKGKsSFTSILT receptor desensitization, altered; receptor internalization, altered 17898803 2 0 0 induced by phorbol ester -ZBTB7A FBI1 C2H2-type zinc finger protein; DNA-binding; Transcription factor O95365 51341 19p13.3 human K61-sm 3982504 ACSQYFKkLFTSGAV BTB molecular association, regulation transcription, inhibited SMRT(INDUCES); N-CoR1(INDUCES); BCOR(INDUCES) 17595526 1 0 0 -FUS hnRNP P2 DNA-binding; Nuclear receptor co-regulator; Oncoprotein; RNA splicing; RNA-binding; SUMO LIGASE P35637 2521 16p11.2 human R518-me 1873375600 MDSRGEHrQDRRERP intracellular localization KPNB2(DISRUPTS) 22968170 1 0 0 Arginines in the RGG3 domain are required for nuclear import of mutant hnRNP, and arginine methylation in this domain reduces KPNB2 binding. -H3-3A H3 DNA-binding Q71LE2 396970 pig K27-m1 465522 LATKAARkSAPSTGG Histone transcription, inhibited 19536841 22 20 47 low levels of trimethylated H3K27 detected -Prkd1 PRKD1 Autophagy; EC 2.7.11.13; KINASE; Kinase, protein; Motility/polarity/chemotaxis; Protein kinase, CAMK; Protein kinase, Ser/Thr (non-receptor) Q62101 18760 12|12 B3 mouse S407-p 3196826 RTISPSTsNNIPLMR enzymatic activity, inhibited 19135240 1 20 2 in vitro -ZWINT ZWINT Cell cycle regulation O95229 11130 10q21.1 human T251-p 20765002 TRPQEQStGDTMGRD Zwint molecular association, regulation; intracellular localization; phosphorylation cell cycle regulation ZW10(INDUCES) 21775627 1 1 0 inhibits phosphorylation of dynein and induces its recruitment with ZW10 to kinetochores, -HTR2A 5-HT(2A) GPCR, family 1; Membrane protein, integral; Membrane protein, multi-pass; Receptor, GPCR P28223 3356 13q14.2 human S280-p 6057802 GTRAKLAsFSFLPQS 7tm_1 receptor desensitization, induced 24637012 2 1 0 -L1CAM NCAM-L1 Cell adhesion; Membrane protein, integral P32004 3897 Xq28 human S1204-p 472276 GDIKPLGsDDSLADY Bravo_FIGEY cytoskeletal reorganization 17151951 2 0 0 -Mybl2 B-Myb DNA-binding; Motility/polarity/chemotaxis; Transcription factor P48972 17865 2 H2|2 84.0 cM mouse S581-p 450115 RKPGLRRsPIKKVRK Cmyb_C activity, induced transcription, induced 10593981; 9840932 5 0 0 -SLC5A6 SLC5A6 Membrane protein, integral; Membrane protein, multi-pass; Transporter; Transporter, SLC family Q9Y289 8884 2p23.3 human T78-p 62925703 VALSLLAtFQSAVAI SSF; TM intracellular localization 28052864 1 0 0 membrane localization, biotin uptake -DTD1 DTD1 DNA replication; EC 3.1.-.-; Hydrolase Q8TEA8 92675 20p11.23 human S196-p 476434 RKEDRSAsSGAEGDV molecular association, regulation cell cycle regulation; cell growth, induced MCM7(INDUCES); MCM3(DISRUPTS) 25258324 1 27 1 decreases DTD1 incorporation into HMW, supports DNA replication initiation -APC2 APCL Membrane protein, peripheral O95996 10297 19p13.3 human S1167-p 33370501 SRCSSVSsLGSFESP APC_r protein degradation; molecular association, regulation transcription, inhibited axin 1(INDUCES) 24722208 1 0 0 -LARP6 LARP6 Q9BRS8 55323 15q23 human S409-p 10942100 GRLNCSTsPEIFRKC molecular association, regulation; intracellular localization translation, induced STRAP(INDUCES) 28112218 2 11 0 regulates collagen production, contributes to LARP6 nuclear distribution, asssociation of LARP6 with ER membrane. -TRIM32 TRIM32 EC 6.3.2.-; EC 6.3.2.19; Ligase; UBIQUITIN LIGASE; Ubiquitin conjugating system; Ubiquitin ligase Q13049 22954 9q33.1 human K401-ub 573767732 RIQVFTRkGFLKEIR protein degradation; intracellular localization autophagy, induced 33999923 1 1 0 -PRKAA1 AMPKA1 Autophagy; EC 2.7.11.1; EC 2.7.11.26; EC 2.7.11.27; EC 2.7.11.31; KINASE; Kinase, protein; Protein kinase, CAMK; Protein kinase, Ser/Thr (non-receptor) Q13131 5562 5p13.1 human K118-sm 1877447402 ELFDYICkNGRLDEK Pkinase protein stabilization 34971706 1 0 0 -Foxa2 FOXA2 DNA-binding; Transcription factor P32182 rat S283-p 8046508 TAPGTQAsQVQLGEA transcription, altered 19478084 1 0 0 -HNRNPK hnRNP K RNA splicing; RNA-binding; Spliceosome P61978 3190 9q21.32 human Y236-p 456003 FYDETYDyGGFTMMF translation, altered 12052863 1 1 0 based on Y72/225/230/234/236/380A mutant -PRC1 PRC1 Cell cycle regulation; Cytoskeletal; Microtubule-binding; Motility/polarity/chemotaxis O43663 9055 15q26.1 human S615-p 4274308 ATSGILNsTNIQS__ molecular association, regulation PLK1(INDUCES) 17351640 2 1 0 phosphorylation and docking site of PLK1 -ATG13 ATG13 Autophagy; Vesicle O75143 9776 11p11.2 human T332-p 27444371 QERLATCtPSDRTHC cell cycle regulation; autophagy, induced; cell growth, induced 32516310 1 2 0 -USP15 USP15 DEUBIQUITINASE; EC 3.4.19.12; Protease; Ubiquitin conjugating system; Ubiquitin-specific protease Q9Y4E8 9958 12q14.1 human S229-p 467037 RGPSTPKsPGASNFS cell cycle regulation 29429988 1 65 31 did not reduce the number of CENP-A-positive micronuclei; promotes genome instability -CCR2 CCR2 GPCR, family 1; Membrane protein, integral; Membrane protein, multi-pass; Receptor, GPCR P41597 729230 3p21.31 human Y139-p 448635 ILLTIDRyLAIVHAV 7tm_1 molecular association, regulation JAK2(INDUCES); STAT3(INDUCES); G-alpha i2(INDUCES) 9670957 1 0 0 -Ager RAGE Cell cycle regulation; Membrane protein, integral; Motility/polarity/chemotaxis; Receptor, misc. Q62151 11596 17|17 B1 mouse S389-p 4731275 ERAELNQsEEAEMPE DNA repair, induced 28977635 4 2 0 -BAX BAX Apoptosis; Membrane protein, integral; Mitochondrial; Tumor suppressor Q07812 581 19q13.33 human T172-p 28847908 FGTPTWQtVTIFVAG TM intracellular localization apoptosis, induced 23907458 1 0 0 -TWIST1 TWIST1 Cell development/differentiation; DNA-binding; Inhibitor; Transcription regulation Q15672 7291 7p21.1 human S20-p 18899300 ADDSLSNsEEEPDRQ protein stabilization carcinogenesis, altered; cell motility, altered 21559372 1 0 0 -Dnm1 DYN1 EC 3.6.5.5; Hydrolase; Microtubule-binding; Motility/polarity/chemotaxis; Motor; Vesicle P21575 140694 3p12 rat S774-p 450205 SVPAGRRsPTSSPTP molecular association, regulation endocytosis, altered endophilin A1(INDUCES); PACSIN1(INDUCES); PACSIN1(DISRUPTS) 16648848; 17437541; 20526333 14 34 21 regulates synaptic vesicle endocytosis; required for activity-dependent bulk endocytosis (ADBE), but not clathrin-mediated endocytosis (CME) ; interaction essential for synaptic vesicle endocytosis -BCL9 Bcl-9 Oncoprotein; Transcription factor O00512 607 1q21.2 human T172-p 3150953 EPTPAQKtPAKVVYV protein stabilization; molecular association, regulation CLTC(DISRUPTS); Myc(INDUCES); CTNNB1(INDUCES) 30217955 1 5 10 stabilizing signalosome and Wnt signaling, promotes oncogenic activity of Bcl-9, regulates cell division -Ankrd54 ANKRD54 Cell cycle regulation Q91WK7 223690 15 E1|15 37.7 cM mouse S18-p 239773903 ESRSGRSsSDGECAV molecular association, regulation; intracellular localization LYN(INDUCES) 28924458 1 1 0 nuclear export, cytoplasmic accumulation -Pea15 PEA-15 Apoptosis; Motility/polarity/chemotaxis Q9Z297 100736554 hamster S116-p 450281 KDIIRQPsEEEIIKL molecular association, regulation FADD(INDUCES) 15916534 15 95 1092 -PTK2 FAK EC 2.7.10.2; KINASE; Kinase, protein; Protein kinase, TK; Protein kinase, tyrosine (non-receptor) Q05397 5747 8q24.3 human S843-p 447963 DVRLSRGsIDREDGS cytoskeletal reorganization 17096371 7 14 7 represses phosphorylation of Y397 in integrin-stimulated cells -EP300 p300 ACETYLTRANSFERASE; Acetyltransferase; EC 2.3.1.48; Motility/polarity/chemotaxis; Nuclear receptor co-regulator; Transcription, coactivator/corepressor Q09472 2033 22q13.2 human K1024-sm 12063901 TELKTEIkEEEDQPS molecular association, regulation transcription, inhibited HDAC6(INDUCES) 12718889 1 1 0 -APC APC Motility/polarity/chemotaxis; Tumor suppressor P25054 324 5q22.2 human S2789-p 2897402 TPFNYNPsPRKSSAD EB1_binding molecular association, regulation EB1(DISRUPTS) 15616574; 19632184 2 14 1 -PDE11A PDE11A EC 3.1.4.17; EC 3.1.4.35; Mitochondrial; Nucleotide Metabolism - purine; Phosphodiesterase Q9HCR9 50940 2q31.2 human S117-p 2243101 GNLQRRAsQKELRKS enzymatic activity, induced 18312413 2 0 0 -ENDOG ENDOG Apoptosis; Deoxyribonuclease; EC 3.1.30.-; Mitochondrial; Ribonuclease Q14249 2021 9q34.11 human S288-p 1871762500 NILARAGsLKAITAG protein degradation; molecular association, regulation autophagy, induced; signaling pathway regulation 14-3-3 gamma(INDUCES) 33473107 1 0 0 binding to 14-3-3 gamma inhibits 14-3-3 gamma binding to TSC2 and Vps34, inhibits mTOR signaling pathway, induces SQSTM1 degradation -Ezr Ezrin Cytoskeletal; Motility/polarity/chemotaxis P26040 22350 17|17 A1 mouse T567-p 448104 QGRDKYKtLRQIRQG ERM_C activity, induced; molecular association, regulation; intracellular localization; phosphorylation cell growth, inhibited; apoptosis, inhibited; cell motility, altered; autophagy, inhibited; cell motility, inhibited; cytoskeletal reorganization; cell adhesion, inhibited Ezrin(INDUCES); MCF2(INDUCES) 12769842; 15196952; 15504914; 15781656; 19890007; 22147261; 24250818; 32154600; 35625669; 9456324 68 9 16 -SRC Src EC 2.7.10.2; KINASE; Kinase, protein; Oncoprotein; Protein kinase, TK; Protein kinase, tyrosine (non-receptor) P00523 396442 chicken S48-p 2420700 PDTHRTPsRSFGTVA phosphorylation cell growth, altered 2474754 3 3 0 Mutation of S16 increases phosphorylation at S12 -STK33 STK33 EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, CAMK; Protein kinase, Ser/Thr (non-receptor) Q9BYT3 65975 11p15.4 human T382-p 25755119 LLDNQWLtGNKLSSV protein degradation; molecular association, regulation; ubiquitination PELI1(INDUCES) 31537781 1 0 1 -SEC63 SEC63 Endoplasmic reticulum; Membrane protein, integral; Membrane protein, multi-pass Q9UGP8 11231 6q21 human S748-p 3215004 DSEGFEDsFEEEEEE molecular association, regulation SEC62(INDUCES) 23287549 1 5 0 -Gapdh GAPDH Carbohydrate Metabolism - glycolysis and gluconeogenesis; EC 1.2.1.12; Oxidoreductase P04797 24383 4q42 rat T227-gl 7533204 PELNGKLtGMAFRVP Gp_dh_C molecular association, regulation; intracellular localization; protein conformation GAPDH(DISRUPTS) 19022411 1 1 0 -Csnk2a1 CK2A1 EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, Other; Protein kinase, Ser/Thr (non-receptor) P19139 116549 3q41 rat Y255-p 450324 VLGTEDLyDYIDKYN Pkinase autophagy, induced 37237886 5 2 14 -DYRK2 DYRK2 iso2 EC 2.7.12.1; KINASE; Kinase, protein; Protein kinase, CMGC; Protein kinase, dual-specificity (non-receptor) Q92630-2 8445 12q15 human T484-p 1874397812 VKRITEStGAITSIS intracellular localization cell cycle regulation; apoptosis, induced 34363019 1 1 0 -PTTG1 Securin Cell cycle regulation; Oncoprotein O95997 9232 5q33.3 human S87-p 3845109 PLKQKQPsFSAKKMT Securin protein degradation; ubiquitination; enzymatic activity, induced chromatin organization, altered 24781523 1 5 0 1) Phosphorylation of securing leads to premature activation of separase. 2) Prevention of securin phosphorylation leads to impaired chromosome segregation and thereby leads to DNA damage. -KLF11 TIEG2 C2H2-type zinc finger protein; DNA-binding; Transcription factor O14901 8462 2p25.1 human T73-p 456008 LLRIRPLtPVSDSGD molecular association, regulation SIN3A(DISRUPTS) 12006497 1 0 1 -NUP98 NUP98 iso2 Motility/polarity/chemotaxis; Nucleoporin P52948-2 4928 11p15.4 human S499-p 18330801 TYSPFGDsPLFRNPM intracellular localization 21335236 1 1 1 as multiple sites (13PM) mutant -Irf8 IRF8 DNA-binding; Transcription factor P23611 15900 8 E1|8 70.05 cM mouse Y211-p 486243 QMVISFYyGGKLVGQ IRF-3 molecular association, regulation transcription, induced PU.1(INDUCES); STAT1(INDUCES) 17386941 1 0 0 as a part of IRF8-PU.1-STAT1 complex binding to LILRE (LPS and IL1 responsive element) regulates IL1B gene expression; Y211F mutant is a dominant-negative inhibitor of LPS-induced IL1B reporter gene -TFCP2 TFCP2 DNA-binding; Transcription factor Q12800 7024 12q13.12-q13.13 human S309-p 7965105 SLGEGNGsPNHQPEP activity, inhibited cell cycle regulation; transcription, inhibited 19237534; 20682773 2 0 0 -Tnnt2 TNNT2 iso2 Motility/polarity/chemotaxis; Motor P50753-2 24837 13q13 rat T285-p 451557 TRGKAKVtGRWK___ Troponin protein conformation 24708997 6 0 0 T204E mutant blunts Ca2+ sensitivity, PKC phosphorylation of these residues can increase or decrease Ca2+ sensitivity and cardiac regulation -SRF SRF Motility/polarity/chemotaxis; Transcription factor P11831 6722 6p21.1 human K165-me 1881502502 YTTFSKRkTGIMKKA cell differentiation, induced; transcription, induced DNA(INDUCES) 33564100 1 0 0 -Ifngr1 IFNGR1 Membrane protein, integral; Receptor, cytokine P15261 15979 10 A3|10 8.49 cM mouse Y467-p 454436 GKESLMGyRLTGEAQ molecular association, regulation SOCS1(INDUCES) 15522878 1 0 1 -Camk2a CAMK2A EC 2.7.11.17; KINASE; Kinase, protein; Protein kinase, CAMK; Protein kinase, Ser/Thr (non-receptor) P11798 12322 18 E1|18 34.41 cM mouse T253-p 451571 DLINKMLtINPSKRI Pkinase enzymatic activity, induced 28065796 8 5 1 ischemia/excitotoxicity induced cell death -FGD1 FGD1 GEF; GEF, misc. P98174 2245 Xp11.22 human S207-p 1876820500 PRAEASPsSAAVSSL cytoskeletal reorganization 35290799 0 1 0 -Slc1a1 SLC1A1 Membrane protein, integral; Membrane protein, multi-pass; Transporter; Transporter, SLC family P51907 25550 1q52 rat T5-p 13204400 ___MGKPtSSGCDWR activity, inhibited 19922365 1 0 0 -RAC2 RAC2 G protein; G protein, monomeric; G protein, monomeric, Rho; Motility/polarity/chemotaxis P15153 5880 22q13.1 human K123-ub 12402500 KLDLRDDkDTIEKLK Ras protein degradation; molecular association, regulation; ubiquitination ALDH2(INDUCES) 35354308 1 7 2 rs671 mutation had significantly lower efferocytotic ability compared with wild-type, ALDH2 WT interacted with RAC2 and stabilized it by inhibited K48-linked polyubiquitination at K123. -Gja1 GJA1 Channel, misc.; Membrane protein, integral; Membrane protein, multi-pass; Motility/polarity/chemotaxis P08050 24392 20q11 rat S306-p 465459 RNYNKQAsEQNWANY Connexin43 activity, induced 19879542 2 20 3 mutation of this site decreases single channel conductance and gating -MAGEA11 MAGE-A11 Cancer Testis Antigen (CTA); Transcription, coactivator/corepressor P43364 4110 Xq28 human T360-p 2028410 GEPKRLLtQNWVQEK MAGE transcription, induced 23853093 3 0 0 induce activation of E2F1 -Plin1 perilipin 1 Lipid-binding Q8CGN5 103968 7|7 D2 mouse S511-p 4759532 ILGRAQYsQLRKKS_ cell differentiation, inhibited; transcription, inhibited 36233344 1 5 0 -Arpp19 ARPP-19 Cell cycle regulation; Phosphatase, regulatory subunit Q712U5 60336 8q24 rat S62-p 465742 KGQKYFDsGDYNMAK Endosulfine enzymatic activity, inhibited 28167675 3 70 47 inhibits PP2A activity -SIAH1 SIAH1 Apoptosis; Cell development/differentiation; EC 6.3.2.-; EC 6.3.2.19; Ligase; Motility/polarity/chemotaxis; UBIQUITIN LIGASE; Ubiquitin conjugating system; Ubiquitin ligase Q8IUQ4 6477 16q12.1 human T70-p 36694104 SNCRPKLtCCPTCRG molecular association, regulation; acetylation; intracellular localization signaling pathway regulation GAPDH(INDUCES) 25391652 1 0 0 augments p300 acetylation; nuclear translocation -SP1 SP1 C2H2-type zinc finger protein; DNA-binding; Transcription factor P08047 6667 12q13.13 human S720-p 36897202 GGPGVALsVGTLPLD protein stabilization; molecular association, regulation; intracellular localization cell cycle regulation RNF4(DISRUPTS) DNA(DISRUPTS) 25398907 1 0 0 -PTEN PTEN Carbohydrate Metabolism - inositol phosphate; EC 3.1.3.16; EC 3.1.3.48; EC 3.1.3.67; Motility/polarity/chemotaxis; Nuclear receptor co-regulator; PHOSPHATASE; Phosphatase, lipid; Tumor suppressor P60484 5728 10q23.31 human T401-p 4695763 EDQHTQItKV_____ molecular association, regulation MAST2(DISRUPTS); DLG1(DISRUPTS) 10646847 1 0 0 -Yap1 YAP1 Oncoprotein; Transcription, coactivator/corepressor Q2EJA0 363014 8q11 rat S112-p 448847 PQHVRAHsSPASLQL protein degradation; intracellular localization; activity, inhibited apoptosis, induced; transcription, inhibited 27369082; 33568044; 35320001 207 33 180 -ADAR ADAR EC 3.5.4.37; Hydrolase; Nucleolus; RNA processing; RNA-binding P55265 103 1q21.3 human S825-p 3193222 TMLLLSRsPEAQPKT phosphorylation carcinogenesis, inhibited; apoptosis, induced 32812257 1 31 2 induces phosphorylation of eIF2 -Rph3a rabphilin 3A Vesicle P47708 19894 5|5 F mouse S271-p 455801 AGLRRANsVQAARPA intracellular localization cytoskeletal reorganization 11466418; 28636945 3 5 0 polarization -KIF11 KIF11 Microtubule-binding; Motor P52732 3832 10q23.33 human S1033-p 20798600 GINTLERsKVEETTE Microtub_bind molecular association, regulation; intracellular localization cell cycle regulation TPX2(INDUCES); ERCC2(DISRUPTS) 21642957; 29276125; 35977011 4 9 0 -CHUK IKKA EC 2.7.11.10; KINASE; Kinase, protein; Protein kinase, Other; Protein kinase, Ser/Thr (non-receptor) O15111 1147 10q24.31 human K296-ub 12109229 GPVDLTLkQPRCFVL Pkinase protein stabilization; intracellular localization; enzymatic activity, induced transcription, induced 35918322 1 3 1 transcription of adhesion molecules promote the adhesion of tumor cells to the endothelium, leading to extravasation, colonization and metastasis -DNMT1 DNMT1 Amino Acid Metabolism - cysteine and methionine; Cell development/differentiation; EC 2.1.1.37; METHYLTRANSFERASE; Methyltransferase; Methyltransferase, DNA; Transcription regulation P26358 1786 19p13.2 human S714-p 452655 DNIPEMPsPKKMHQG molecular association, regulation; intracellular localization; protein conformation; enzymatic activity, induced carcinogenesis, induced; cell growth, induced; chromatin organization, altered; transcription, inhibited DNA(INDUCES) 32071079; 35402240 4 69 10 -SDCBP syntenin Adaptor/scaffold; Cell adhesion; Cytokine; Membrane protein, integral; Motility/polarity/chemotaxis; Vesicle O00560 6386 8q12.1 human S131-p 56649728 KIGLRLKsIDNGIFV Peptidase_M50; PDZ protein stabilization; molecular association, regulation carcinogenesis, induced; signaling pathway regulation Src(INDUCES); EGFR(INDUCES); FAK(INDUCES) 32572158 1 1 0 AURKA-SDCBP-EGFR-PI3K-AKT pathway; Inhibits ubiquitination -SAV1 SAV1 Adaptor/scaffold Q9H4B6 60485 14q22.1 human S269-p 21507301 YRHPCAPsVPRYDQP protein conformation apoptosis, induced 21944251 1 1 0 self-dimerization; increase in protein level -MOB1A MOB1A Protein kinase, regulatory subunit Q9H8S9 55233 2p13.1 human Y26-p 465048 IPEGSHQyELLKHAE molecular association, regulation; intracellular localization STEP(INDUCES) 28675297 2 3 169 dephosphorylation at this site by PTPN5 is critical for its midbody localization -Slc43a2 SLC43A2 Membrane protein, integral; Membrane protein, multi-pass; Transporter; Transporter, SLC family Q8CGA3 215113 11|11 B5 mouse S274-p 2508983 TTVGRRLsVGSSMRT MFS_1 intracellular localization 32470053 2 28 1 -USP10 USP10 DEUBIQUITINASE; EC 3.4.19.12; Protease; RNA-binding; Ubiquitin conjugating system; Ubiquitin-specific protease Q14694 9100 16q24.1 human T42-p 12483201 SGTVLCGtQAVDKLP protein stabilization; ubiquitination; intracellular localization carcinogenesis, inhibited; cell growth, altered 20096447 1 0 0 regulates p53 homeostasis -VPS13D VPS13D Vesicle Q5THJ4 55187 1p36.22-p36.21 human Y768-p 25316392 TQFSDDEyKTPLATP VPS13_mid_rpt molecular association, regulation; intracellular localization VAPB(INDUCES) 33891013 1 0 1 -MAFA MAFA DNA-binding; Oncoprotein; Transcription factor; Tumor suppressor Q8NHW3 389692 8q24.3 human S49-p 1320400 CHRLPPGsLSSTPLS protein degradation; molecular association, regulation; ubiquitination carcinogenesis, induced; transcription, induced PCAF(INDUCES) 18042454 4 1 0 -GATA4 GATA4 Motility/polarity/chemotaxis; Transcription factor P43694 2626 8p23.1 human K327-ac 1877203100 RKPKNLNkSKTPAAP apoptosis, inhibited; transcription, induced 32239217 1 0 0 -TGFBR2 TGFBR2 EC 2.7.11.30; KINASE; Kinase, protein; Membrane protein, integral; Oncoprotein; Protein kinase, Ser/Thr (receptor); Protein kinase, TKL P37173 7048 3p24.1 human Y259-p 2869604 KGRFAEVyKAKLKQN PK_Tyr_Ser-Thr enzymatic activity, induced transcription, altered 9169454 2 0 0 -HJURP HJURP Histone-binding; Nucleolus Q8NCD3 55355 2q37.1 human S211-p 17555083 DPAKPASsPREWDPL molecular association, regulation cell cycle regulation 28017591 1 4 0 prevents premature CENP-A assembly -Stat6 STAT6 DNA-binding; Transcription factor P52633 20852 10 D3|10 74.59 cM mouse Y641-p 447757 MGKDGRGyVSTTIKM protein degradation; intracellular localization cell differentiation, induced; transcription, induced; transcription, altered; signaling pathway regulation 12244176; 33504618; 33736980; 34795444; 36057627 27 6 95 -ETS1 Ets-1 DNA-binding; Motility/polarity/chemotaxis; Oncoprotein; Transcription factor P14921 2113 11q24.3 human Y283-p 449428 SLQRVPSyDSFDSED Ets1_N_flank protein stabilization; molecular association, regulation carcinogenesis, induced; cell motility, induced; transcription, altered COP1(DISRUPTS); SP1(INDUCES) 25117710; 36305724 2 5 18 -DCLRE1C Artemis DNA repair, damage; Deoxyribonuclease; EC 3.1.-.- Q96SD1 64421 10p13 human S645-p 457531 NLSTNADsQSSSDFE molecular association, regulation; ubiquitination; intracellular localization cell cycle regulation; DNA repair, induced FBXW7(INDUCES); PAXIP1(INDUCES) 16600297; 17242184; 19423708; 25512557 6 2 0 facilitates recovery from the replication checkpoint in response to DNA damage; Artermis regulates Cdk1-cyclin B during IR-induced G2/M arrest and Cdk1-cyclin B nuclear import.; Artemis prevents end resection and promotes non-homologous end joining; interaction with FBXW7 stimulates ubiquitination and degradation of cyclin E -PHF5A PHF5A RNA splicing; RNA-binding Q7RTV0 84844 22q13.2 human Y36-p 463988 KCVICDSyVRPCTLV PHF5 cell cycle regulation; carcinogenesis, induced; cell motility, induced; cell growth, induced; cytoskeletal reorganization 36759599 1 2 4 -Def6 DEF6 GEF; GEF, Rac/Rho Q8C2K1 23853 17|17 A3.3 mouse Y133-p 6094305 NFLSEDKyPLIMVPD activity, induced; intracellular localization cell differentiation, altered; transcription, altered 18976935 1 0 0 -IFIH1 MDA5 Apoptosis; EC 3.6.4.13; Helicase Q9BYX4 64135 2q24.2 human K743-ub 62495529 QWITENEkFAEVGVK Helicase_C activity, induced; molecular association, regulation transcription, induced MDA5(INDUCES) 28031478 1 1 0 oligomerization, activation, induces antiviral innate immunity -Map2 MAP2 iso3 Cytoskeletal; Motility/polarity/chemotaxis P15146-3 25595 9q32 rat K352-ac 62495515 TSKCGSLkNIRHRPG Tubulin-binding cytoskeletal reorganization 28002468 1 1 0 -ABL1 Abl iso2 EC 2.7.10.2; KINASE; Kinase, protein; Oncoprotein; Protein kinase, TK; Protein kinase, tyrosine (non-receptor) P00519-2 25 9q34.12 human Y412-p 450298 RLMTGDTyTAHAGAK PK_Tyr_Ser-Thr enzymatic activity, induced apoptosis, induced; transcription, altered 11781820; 22975324 24 49 1642 -LIFR LIFR Membrane protein, integral; Receptor, cytokine P42702 3977 5p13.1 human S1044-p 450385 WNLVSPDsPRSIDSN activity, induced; protein degradation; molecular association, regulation; intracellular localization; activity, inhibited; phosphorylation carcinogenesis, induced; cell motility, induced; cell growth, induced; cell adhesion, induced; signaling pathway regulation; transcription, inhibited LIFR(INDUCES) 10858440; 18624908; 22306348; 30851421; 35172032; 7777512 7 6 0 necessary for homodimerization and subsequent S1044 phosphorylation, and consequent AKT activation, and PCa progression, promoted the growth and metastasis of PCa cells; PI3K-AKT pathway -Erbb2 HER2 EC 2.7.10.1; KINASE; Kinase, protein; Membrane protein, integral; Oncoprotein; Protein kinase, TK; Protein kinase, tyrosine (receptor) P06494 24337 10q31 rat Y879-p 448694 LDIDETEyHADGGKV PK_Tyr_Ser-Thr molecular association, regulation; phosphorylation cell growth, altered EGFR(INDUCES) 15163624; 9671404 25 14 111 -RAPH1 RAPH1 Adaptor/scaffold; Motility/polarity/chemotaxis Q70E73 65059 2q33.2 human Y1226-p 458696 GGSHISGyATLRRGP molecular association, regulation cell motility, induced 26996666 2 8 122 Lpd-Scar/WAVE interaction is positively regulated by c-Abl and c-Src, breast cancer cell invasion -Map3k2 MEKK2 EC 2.7.11.25; KINASE; Kinase, protein; Protein kinase, STE; Protein kinase, Ser/Thr (non-receptor) F1M9D0 171492 18p12 rat S239-p 3216828 SRMPRAQsYPDNHQE apoptosis, induced 28039298 1 46 239 -Scnn1b ENaC-beta Channel, sodium; Membrane protein, integral; Membrane protein, multi-pass; Transporter, ion channel Q9WU38 20277 7 F2|7 65.07 cM mouse T613-p 451219 QTLPIPGtPPPNYDS activity, inhibited 17724164 6 1 0 T613A mutation causes a reduced inhibitory response of EGF on reduction of short circuit current. Most likely a change in open probability. -TLN1 talin 1 Cytoskeletal; Motility/polarity/chemotaxis Q9Y490 7094 9p13.3 human T144-p 3801749 KKEEITGtLRKDKTL cell motility, altered; cell adhesion, induced 27698901 1 7 18 -Myo3b MYO3B Actin-binding; EC 2.7.11.1; KINASE; Kinase, protein; Motor; Protein kinase, STE; Protein kinase, Ser/Thr (non-receptor) Q1EG27 329421 2|2 C2 mouse S171-p 36841905 GVSAQLTsTRLRRNT Pkinase enzymatic activity, induced 21895655 1 1 0 -Lsr LISCH iso2 Membrane protein, integral; Receptor, misc. Q99KG5-2 54135 7|7 B1 mouse S288-p 4771509 PGDFDRTsSVGGHSS intracellular localization 24889144 1 2 0 at tricellular tight junctions -MT-CO1 COX1 EC 1.9.3.1; Energy Metabolism - oxidative phosphorylation; Membrane protein, integral; Membrane protein, multi-pass; Mitochondrial; Oxidoreductase P00395 4512 - human K13-ac 1879877105 WLFSTNHkDIGTLYL apoptosis, induced 31647884 1 0 0 mutant sites were found to significantly suppressed the AAPH-evoked increase in both ROS level and apoptosis -RPA2 RFA2 DNA replication P15927 6118 1p35.3 human S4-p 470082 ____MWNsGFESYGS molecular association, regulation; intracellular localization cell cycle regulation; DNA repair, induced; carcinogenesis, inhibited; apoptosis, induced; transcription, altered; cell growth, altered p53(INDUCES) 17035231; 18003706; 18289945; 21731742; 29875999; 30573684; 32989256; 37409248 48 2 0 -KIF18A KIF18A Microtubule-binding; Motor Q8NI77 81930 11p14.1 human S674-p 3207069 TRRKLMPsPLKGQHT molecular association, regulation; enzymatic activity, inhibited cell cycle regulation PPP2R2C(DISRUPTS); PPP2R3B(INDUCES); PPP2R5C(DISRUPTS); PPP2R3A(INDUCES) 32900880 0 9 0 -KCNIP3 calsenilin Calcium-binding; Transcription factor Q9Y2W7 30818 2q11.1 human S95-p 471337 FTKKELQsLYRGFKN intracellular localization 17102134 1 0 0 inhibits trafficking of Kv4.2 potassium channels to the plasma membrane -SPP1 osteopontin Secreted; Secreted, signal peptide P10451 6696 4q22.1 human S129-p 455740 ESHHSDEsDELVTDF Osteopontin molecular association, regulation; activity, inhibited Other(INDUCES) 19775205 1 5 0 peptide with phosphorylated S117, S120, S123, S126 and S129 has increased binding to hydroxyapatite, and inhibits bone mineralization in vivo and in vitro -Nrip1 RIP140 Nuclear receptor co-regulator; Transcription, coactivator/corepressor Q8CBD1 268903 16|16 C3.1 mouse S102-p 3345202 AAKRKRLsDSIVNLN NRIP1_repr_1 molecular association, regulation; methylation; intracellular localization transcription, altered 14-3-3 beta(INDUCES); PRMT1(INDUCES) 18628823 1 2 0 regulates fat accumulation -MYH7 MYH7 Motility/polarity/chemotaxis; Motor P12883 4625 14q11.2 human K213-ac 1881951900 KKDQSPGkGTLEDQI protein conformation 35502901 0 1 0 -MAK MAK EC 2.7.11.22; KINASE; Kinase, protein; Nuclear receptor co-regulator; Protein kinase, CMGC; Protein kinase, Ser/Thr (non-receptor) P20794 4117 6p24.2 human T157-p 4715052 LRSQPPYtDYVSTRW Pkinase phosphorylation; enzymatic activity, induced cell cycle regulation 21986944 1 3 614 phosphorylates myelin basic proteins and CDH1 -PRMT7 PRMT7 EC 2.1.1.125; EC 2.1.1.126; METHYLTRANSFERASE; Methyltransferase; Methyltransferase, protein arginine; RNA processing Q9NVM4 54496 16q22.1 human R531-m1 63128900 FRDLWRIrSPCGDCE molecular association, regulation carcinogenesis, induced; cell motility, induced; transcription, inhibited YY1(INDUCES) 28188177 1 1 0 -SSTR5 SSTR5 Cell cycle regulation; GPCR, family 1; Membrane protein, integral; Membrane protein, multi-pass; Receptor, GPCR P35346 6755 16p13.3 human T333-p 27724400 GAKDADAtEPRPDRI receptor internalization, induced; receptor recycling, induced 23418396; 24637622 2 0 0 -PXN PXN Adaptor/scaffold; Cell adhesion; Cytoskeletal; Motility/polarity/chemotaxis P49023 5829 12q24.23 human S130-p 450228 KQKSAEPsPTVMSTS Paxillin cell motility, induced; cytoskeletal reorganization 23549785 5 25 4 HGF mediated disassembly of focal adhesions and cell migration -Cckar CCKAR GPCR, family 1; Membrane protein, integral; Membrane protein, multi-pass; Receptor, GPCR P30551 24889 14q11 rat S260-p 451123 QGIKFDAsQKKSAKE 7tm_1 receptor desensitization, altered 11078715 2 0 0 -Atp1a1 ATP1A1 EC 3.6.3.9; Hydrolase; Membrane protein, integral; Membrane protein, multi-pass; Transporter; Transporter, ion channel P06685 24211 2q34 rat Y10-p 452054 KGVGRDKyEPAAVSE activity, induced; enzymatic activity, inhibited 10473631; 28344437 2 9 208 -TKT TKT Carbohydrate Metabolism - pentose phosphate pathway; EC 2.2.1.1; Transferase P29401 7086 3p21.1 human T382-p 34711200 GCATRNRtVPFCSTF Transket_pyr activity, induced; enzymatic activity, induced 24981175; 31534226 2 0 2 Rugulation of Low Barrier Hydrogen Bonds (LBHB) -Pfn2 profilin 2 Actin-binding; Motility/polarity/chemotaxis Q9JJV2 18645 3 D|3 28.15 cM mouse S138-p 35541800 MAKYLRDsGF_____ Profilin neural plasticity; cytoskeletal reorganization 36875774 2 0 0 -CCP110 CP110 Cell cycle regulation O43303 9738 16p12.3 human T194-p 2024013 FPKTSSAtPQETLIS intracellular localization cell cycle regulation 12361598 2 2 0 -PTPN11 SHP-2 iso1 EC 3.1.3.48; Motility/polarity/chemotaxis; PHOSPHATASE; Protein phosphatase, tyrosine (non-receptor) Q06124-1 5781 12q24.13 human Y584-p 448493 REDSARVyENVGLMQ molecular association, regulation; enzymatic activity, induced GAB2(INDUCES) 23980151 18 60 1189 -Cd79a Ig-alpha Immunoglobulin superfamily; Membrane protein, integral P11911 12518 7 A3|7 13.49 cM mouse S197-p 21127303 CSMYEDIsRGLQGTY ITAM activity, inhibited; phosphorylation signaling pathway regulation 20940318; 21841126 3 0 0 negatively regulates B-cell antigen receptor signaling; modulates T cell independent type II Ag response; phosphorylation at this site inhibits in vivo phosphorylation of tyrosine in Ig alpha -Ikbkb IKKB EC 2.7.11.10; KINASE; Kinase, protein; Protein kinase, Other; Protein kinase, Ser/Thr (non-receptor) Q9QY78 84351 16q12.5 rat S181-p 447489 DQGSLCTsFVGTLQY Pkinase enzymatic activity, induced cell growth, altered 15935065 76 2 0 -Itk ITK EC 2.7.10.2; KINASE; Kinase, protein; Protein kinase, TK; Protein kinase, tyrosine (non-receptor) Q03526 16428 11 B1.1|11 27.75 cM mouse Y517-p 447997 RFVLDDQyTSSTGTK PK_Tyr_Ser-Thr phosphorylation; enzymatic activity, induced 12842872 3 8 260 stimulates phosphorylation of ITK Y186 -ELMO1 ELMO1 Cytoskeletal; Motility/polarity/chemotaxis Q92556 9844 7p14.2-p14.1 human Y724-p 455566 PSNYDFVyDCN____ cell motility, induced; cell adhesion, induced 26205662 2 5 175 -SHMT1 SHMT1 Amino Acid Metabolism - glycine, serine and threonine; Cofactor and Vitamin Metabolism - one carbon pool by folate; EC 2.1.2.1; Energy Metabolism - methane; Lyase; METHYLTRANSFERASE; Methyltransferase; Mitochondrial; Other Amino Acids Metabolism - cyanoamino acid P34896 6470 17p11.2 human K38-sm 12004406 VEVYNIIkKESNRQR SHMT intracellular localization 17446168 1 1 0 -AKAP5 AKAP5 Adaptor/scaffold P24588 9495 14q23.3 human T87-p 406855301 ASLKRLVtRRKRSES WSK molecular association, regulation ACTB(INDUCES) 29196604 1 0 0 AKAP5 de-palmitoylation, AKAP5 from dendritic spines -NUAK1 NuaK1 EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, CAMK; Protein kinase, Ser/Thr (non-receptor) O60285 9891 12q23.3 human S480-p 33406501 QRESGYYsSPERSES molecular association, regulation cell cycle regulation BRD8(INDUCES) 24785407 1 1 0 -Prkcq PKCT EC 2.7.11.13; KINASE; Kinase, protein; Protein kinase, AGC; Protein kinase, Ser/Thr (non-receptor) Q02111 18761 2 A1|2 8.42 cM mouse T219-p 457380 SAINSREtMFHKERF activity, induced 31694643 2 1 0 T cell activation -MAP3K5 ASK1 EC 2.7.11.25; KINASE; Kinase, protein; Protein kinase, STE; Protein kinase, Ser/Thr (non-receptor) Q99683 4217 6q23.3 human T1109-p 27928508 DRKIIATtLSKLKLE HisK-N-like enzymatic activity, inhibited carcinogenesis, induced 23608533 1 1 0 -Gabrb3 GABRB3 Channel, chloride; Channel, ligand-gated; Membrane protein, integral; Membrane protein, multi-pass; Transporter; Transporter, ion channel P63080 14402 7 B5|7 33.53 cM mouse S432-p 450245 KTHLRRRsSQLKIKI Neur_chan_memb molecular association, regulation cytoskeletal reorganization AP-2 alpha(DISRUPTS) 18184780; 26627235 12 0 0 increased dendritic spine density, alterations in GABRB3 expression, decreased social interaction and repetitive-like behavior in S408/9A mice -CUEDC2 CUEDC2 Q9H467 79004 10q24.32 human S110-p 18008416 VQGQVPIsPEPLQRP molecular association, regulation cell cycle regulation CDC20(INDUCES) 21743465 1 13 0 -Ppargc1a PGC-1 alpha Nuclear receptor co-regulator; Transcription, coactivator/corepressor O70343 19017 5|5 C1 mouse S194-p 13861601 SWSNKAKsICQQQKP intracellular localization transcription, induced 20351112 1 0 0 -CBX5 HP1 alpha Transcription, coactivator/corepressor P45973 23468 12q13.13 human S92-p 455944 SESNKRKsNFSNSAD cell cycle regulation; chromatin organization, altered 31130069 4 39 18 protect the cells against mitotic and chromosomal aberrations (regulates chromosomal stability) -VIM Vimentin Cytoskeletal; Motility/polarity/chemotaxis P08670 7431 10p13 human S83-p 451816 GVRLLQDsVDFSLAD Filament_head molecular association, regulation carcinogenesis, induced; cell motility, induced; cell growth, induced; cell motility, altered CDK1(INDUCES) 18056432; 27603133; 33963314 18 26 0 -PRPF3 PRPF3 RNA processing; RNA splicing; Spliceosome O43395 9129 1q21.2 human K289-sm 1872852108 KANIRAVkREQFKQQ molecular association, regulation RNA splicing, induced EFTUD2(INDUCES); SF3A1(INDUCES); PRP4(INDUCES) 28379520 1 0 0 -RREB1 RREB1 C2H2-type zinc finger protein; DNA-binding; Motility/polarity/chemotaxis; Nuclear receptor co-regulator; Transcription, coactivator/corepressor Q92766 6239 6p24.3 human K60-ac 1881352800 GRRNQETkEEKSSYN acetylation transcription, inhibited 34419497 1 1 0 wild-type pRREB1 and pRREB1 K60Q (mimetic mutant) had little influence on the binding of the encoded proteins RREB1 with the AKT1 promoter, while the K60R mutant AKT1 expression was increased. -Smarca2 SMARCA2 EC 3.6.1.-; EC 3.6.4.-; Helicase; Nuclear receptor co-regulator; Transcription, coactivator/corepressor Q6DIC0 67155 19 C1|19 21.17 cM mouse S1382-p 470425 RPPAEKLsPNPPKLT molecular association, regulation transcription, induced MTA3(DISRUPTS); TADA2B(DISRUPTS); HDAC2(DISRUPTS); SMC3(DISRUPTS); MTA1(DISRUPTS) 34260936 1 35 2 -BRAF BRAF EC 2.7.11.1; KINASE; Kinase, protein; Oncoprotein; Protein kinase, Ser/Thr (non-receptor); Protein kinase, TKL Q04982 396239 chicken S769-p 450242 PKIHRSAsEPSLNRA molecular association, regulation; enzymatic activity, induced 14-3-3 beta(INDUCES) 16702958 8 59 25 effect on kinase activity measured in vitro -PKP1 plakophilin 1 Cell adhesion; Motility/polarity/chemotaxis Q13835 5317 1q32.1 human S118-p 4712605 EPDNRRFsSYSQMEN intracellular localization 23444369 1 6 2 -Rfc1 RFC1 DNA replication D3ZFT1 89809 14p11 rat S71-p 452681 RIIYDSDsESEETVQ intracellular localization transcription, inhibited 10625661 1 65 4 -Twist1 TWIST1 Cell development/differentiation; DNA-binding; Inhibitor; Transcription regulation P26687 22160 12 A3|12 14.81 cM mouse S42-p 14821304 GARKRRSsRRSAGGS carcinogenesis, induced; transcription, induced 20400976; 27281171; 28915063; 32922123 5 1 0 -Cldn6 Claudin-6 Cell adhesion; Membrane protein, integral; Membrane protein, multi-pass Q9Z262 54419 17|17 A3.3 mouse Y196-p 7792482 GTQGPRHyMACYSTS cell adhesion, altered; signaling pathway regulation 31740618 1 0 17 -ERG ERG DNA-binding; Oncoprotein; Transcription factor P11308 2078 21q22.2 human S37-p 50259801 KTEMTASsSSDYGQT protein degradation; molecular association, regulation; ubiquitination cell motility, inhibited SPOP(INDUCES) 26344095; 26344096 2 1 0 -PXN PXN iso2 Adaptor/scaffold; Cell adhesion; Cytoskeletal; Motility/polarity/chemotaxis P49023-2 5829 12q24.23 human Y118-p 448604 VGEEEHVySFPNKQK Paxillin activity, induced; protein degradation; molecular association, regulation; intracellular localization; phosphorylation cell cycle regulation; apoptosis, altered; cell motility, induced; cell motility, altered; cytoskeletal reorganization; transcription, altered Src(INDUCES); CRKL(INDUCES) 15870699; 16491114; 17046825; 17574549; 18045996; 18794113; 20628053; 21898535; 7493940 83 79 2519 induces phosphorylation of IKB; essential for EGFR-mediated Erk1/2 activation and cell proliferation -NELFE RDBP Mitochondrial; Transcription, coactivator/corepressor P18615 7936 6p21.33 human S115-p 452641 QPFQRSIsADDDLQE molecular association, regulation transcription, induced 14-3-3 epsilon(INDUCES) 29523821 1 82 18 dissociation of the NELF complex from chromatin, which is accompanied by RNA polymerase II elongation -EIF5A2 EIF5A2 Q9GZV4 56648 3q26.2 human K47-ub 964512658 IVEMSTSkTGKHGHA protein degradation 35064108 1 2 0 regulate EMT, and may inhibit the metastasis of CRC -IRF1 IRF1 Transcription factor; Tumor suppressor P10914 3659 5q31.1 human S221-p 31839601 VSPMPSTsEATTDED molecular association, regulation; activity, inhibited transcription, inhibited NFkB-p65(DISRUPTS) 24396068 1 0 0 Phosphorylation impairs iNFkB-p65 interaction and PCAF mediated acetylation K310 -suppression of IFN-beta production -BRCA2 BRCA2 DNA repair, damage; Nuclear receptor co-regulator; Tumor suppressor P51587 675 13q13.1 human S193-p 469574 AEVDPDMsWSSSLAT molecular association, regulation; intracellular localization; enzymatic activity, induced cytoskeletal reorganization MYH14(INDUCES) 24448238 2 2 0 Inhibiting this binding inactivated the ATPase activity, formation of the midbody, and interruption of cytokinesis.; localizes to Flemming body -SLC12A1 NKCC2 Membrane protein, integral; Membrane protein, multi-pass; Transporter; Transporter, SLC family Q13621 6557 15q21.1 human S91-p 4708924 ASFHAYDsHTNTYYL AA_permease_N signaling pathway regulation 21321328 1 2 0 WNK-SPAK-OSR1 pathway -NDC80 HEC1 Cell cycle regulation O14777 10403 18p11.32 human T31-p 23112540 VNKQGLYtPQTKEKP cell cycle regulation; cytoskeletal reorganization 35878017; 36897279 2 7 1 -HDAC3 HDAC3 Apoptosis; Cell cycle regulation; DEACETYLASE; Deacetylase; EC 3.5.1.98; Nuclear receptor co-regulator; Transcription, coactivator/corepressor O15379 8841 5q31.3 human Y325-p 1267669100 AISEELPySEYFEYF activity, induced cell growth, induced 30317579 1 0 0 cell proliferation increased in HER2-positive breast cancer cells -PKP3 plakophilin 3 Cell adhesion Q9Y446 11187 11p15.5 human Y195-p 451533 PGGLDDRySLVSEQL intracellular localization 25501895 1 15 160 desmosome disassembly and function -Sox9 SOX9 DNA-binding; Transcription factor Q04887 20682 11 E2|11 77.27 cM mouse R177-me 10338209 PDYKYQPrRRKSVKN molecular association, regulation cell cycle regulation; cell growth, induced; transcription, induced CTNNB1(DISRUPTS) 19725955 1 0 0 promotes cyclin D1 expression, regulates endochondral ossification, chondrocyte/cartilage development during embryogenesis -Ppp3cb PPP3CB EC 3.1.3.16; PHOSPHATASE; Protein phosphatase, Ser/Thr (non-receptor) P48453 19056 14|14 A3 mouse K327-ub 1878212800 YLDVYNNkAAVLKYE cell cycle regulation; cell growth, inhibited; transcription, inhibited 31135381 1 1 0 USP16 regulates T cell proliferation and cell-cycle entry; Ubiquitination of PPP3CB impairs NFAT recruitment and transcription of NFAT-targeted genes -CAMK2D CAMK2D EC 2.7.11.17; KINASE; Kinase, protein; Protein kinase, CAMK; Protein kinase, Ser/Thr (non-receptor) Q13557 817 4q26 human T306-p 2023845 KLKGAILtTMLATRN enzymatic activity, inhibited 34391760 2 4 1 -XKR5 XKR5 Membrane protein, integral; Membrane protein, multi-pass Q6UX68 389610 8p23.1 human Y369-p 1172732401 GSCQGASyEPTILGK phosphorylation carcinogenesis, inhibited; cell growth, inhibited; signaling pathway regulation 29910466 1 1 0 inhibits phosphorylation of ERK, AKT and p38 -ERN1 IRE1 Apoptosis; Chaperone; EC 2.7.11.1; Endoplasmic reticulum; KINASE; Kinase, protein; Membrane protein, integral; Protein kinase, Other; Protein kinase, Ser/Thr (non-receptor); Ribonuclease O75460 2081 17q23.3 human S724-p 7161100 KLAVGRHsFSRRSGV Pkinase enzymatic activity, induced endocytosis, induced; autophagy, induced; RNA splicing, induced; apoptosis, induced; transcription, altered 16950141; 30045994; 36170818; 36739529 18 2 0 -CGAS cGAS EC 2.7.7.86 Q8N884 115004 6q13 human K394-ac 14366393 LNNHGKSkTCCENKE enzymatic activity, inhibited; protein conformation; activity, inhibited 30799039; 33438687 2 2 0 -RAF1 RAF1 EC 2.7.11.1; KINASE; Kinase, protein; Oncoprotein; Protein kinase, Ser/Thr (non-receptor); Protein kinase, TKL P04049 5894 3p25.2 human S259-p 447741 SQRQRSTsTPNVHMV protein stabilization; molecular association, regulation; intracellular localization; enzymatic activity, inhibited; phosphorylation cell differentiation, inhibited; cell cycle regulation; carcinogenesis, induced; apoptosis, altered; carcinogenesis, inhibited; cell motility, induced; transcription, induced; signaling pathway regulation; cell growth, induced; apoptosis, inhibited; cell growth, altered 14-3-3 beta(INDUCES); 14-3-3 theta(INDUCES); 14-3-3 zeta(INDUCES); MST2(INDUCES); HRas(DISRUPTS); PPP2CB(DISRUPTS) 10801873; 11756411; 11971957; 12609989; 12801936; 12865432; 16093354; 20212043; 20234004; 20679480; 20868520; 24929361; 34473994; 35564180; 35697074; 35810308; 35884549; 36564468; 8321321; 8637718 58 32 142 -Pten PTEN Carbohydrate Metabolism - inositol phosphate; EC 3.1.3.16; EC 3.1.3.48; EC 3.1.3.67; Motility/polarity/chemotaxis; Nuclear receptor co-regulator; PHOSPHATASE; Phosphatase, lipid; Tumor suppressor O08586 19211 19 C1|19 28.14 cM mouse S398-p 4695758 PFDEDQHsQITKV__ molecular association, regulation; intracellular localization; methylation; phosphorylation cell cycle regulation; carcinogenesis, induced; DNA repair, induced; carcinogenesis, inhibited; apoptosis, induced; apoptosis, inhibited; signaling pathway regulation MDC1(INDUCES); WHSC1(INDUCES) 31217297; 34059798 3 0 0 inhibits H2AX and CDK2 phosphorylation, inhibits AKT/p27Kip1 signaling; induces NSD2 mediated dimethylation of PTEN -H2AC11 H2A.1 DNA-binding P0C0S8 8329 6p22.1 human S1-p 451190 _______sGRGKQGG Histone activity, inhibited transcription, inhibited 15010469 3 3 0 -Ncf4 p40phox Oxidoreductase P97369 17972 15 E1|15 37.1 cM mouse T154-p 448266 LRRLRPRtRKIKGVS intracellular localization 20861461 5 0 0 translocation to S aureus phagosomes; essential for NADPH oxidase activity -SMURF2 SMURF2 EC 6.3.2.-; EC 6.3.2.19; Ligase; UBIQUITIN LIGASE; Ubiquitin conjugating system; Ubiquitin ligase Q9HAU4 64750 17q23.3-q24.1 human K734-ub 50760802 SYEKLYEkLLTAIEE HECT enzymatic activity, induced cell motility, induced; signaling pathway regulation 26435193 1 0 0 regulates TGF-beta signaling pathway (TGF-beta activity and biological effects), induces SMURF2 transthiolation -HTT Huntingtin Cytoskeletal P42858 3064 4p16.3 human K442-ac 7434500 LSRKQKGkVLLGEEE protein degradation; intracellular localization autophagy, induced 19345187 3 2 0 -NFKBIA IkB-alpha DNA-binding; Inhibitor P25963 4792 14q13.2 human K21-sm 2535907 EGPRDGLkKERLLDD activity, induced; protein stabilization; ubiquitination transcription, induced; transcription, inhibited 17956732; 20696840; 32770227; 9734360 6 0 0 inhibits ubiquitination -SREBF1 SREBP-1 DNA-binding; Membrane protein, integral; Membrane protein, multi-pass; Transcription factor P36956 6720 17p11.2 human S439-p 469115 AGSPFQSsPLSLGSR protein stabilization cell cycle regulation; transcription, induced 16880739 1 0 0 specific for mitotic cells regulates G1/S cell cycle -KAT5 Tip60 ACETYLTRANSFERASE; Acetyltransferase; EC 2.3.1.48; Nuclear receptor co-regulator; Nucleolus Q92993 10524 11q13.1 human K120-ac 52498000 TLRFNLPkEREAIPG protein degradation; intracellular localization apoptosis, altered 25301942 1 0 0 HDAC3 increased the TIP60 half-life, and the ubiquitination level of TIP60, nuclear localization, cytoplasm and nucleus with HDAC3 expressed, TIP60 deacetylation increases its resistance to apoptosis -Dzip1 DZIP1 C2H2-type zinc finger protein Q8BMD2 66573 14|14 E4 mouse S520-p 40586900 KPSSTSPsPQELRTN molecular association, regulation GDI2(INDUCES) 25860027 1 1 0 ciliogenesis -SRF SRF Motility/polarity/chemotaxis; Transcription factor P11831 6722 6p21.1 human S83-p 451800 YSGSEGDsESGEEEE molecular association, regulation DNA(INDUCES) 1547771 3 6 0 -CABLES1 CABLES1 Adaptor/scaffold Q8TDN4 91768 18q11.2 human T309-p 4270180 APLRRCRtLSGSPRP molecular association, regulation; phosphorylation; enzymatic activity, induced carcinogenesis, induced; apoptosis, inhibited; transcription, altered 14-3-3 gamma(INDUCES); CDK2(DISRUPTS) 25361894 1 2 10 inhibits phosphorylation of Cdk2 and increases its kinase activity, decreaes p21 and increases phosphorylated Rb protein levels -PPP2CA PPP2CA EC 3.1.3.16; Motility/polarity/chemotaxis; PHOSPHATASE; Protein phosphatase, Ser/Thr (non-receptor) P67775 5515 5q31.1 human Y307-p 448571 VTRRTPDyFL_____ molecular association, regulation; methylation; intracellular localization; enzymatic activity, inhibited; activity, inhibited; phosphorylation; enzymatic activity, induced cell cycle regulation; carcinogenesis, induced; apoptosis, altered; transcription, induced; signaling pathway regulation; cell growth, induced; autophagy, inhibited; cytoskeletal reorganization; translation, induced; cell growth, altered; translation, inhibited LCMT1(INDUCES); JAK2(DISRUPTS); PPP2R3A(DISRUPTS); PPP2R5D(NOT_REPORTED); PPP2R2A(DISRUPTS); PPP2R5A(NOT_REPORTED); ASH2L(INDUCES) 10978272; 12921784; 17303700; 17394530; 19366811; 20450893; 20558158; 20636478; 21292165; 21554241; 21791414; 22231169; 23251465; 23428800; 23720779; 23926298; 24395787; 24632852; 24676687; 24997451; 25931585; 26378614; 35015571; 37043557; 37437018 73 1 0 may contribute to SNCA accumulation; inhibits S6K dephosphorylation thus inhibiting the mTOR/S6K pathway -SERINC3 SERINC3 Cell surface; Membrane protein, integral; Membrane protein, multi-pass Q13530 10955 20q13.12 human S380-p 1255792401 ILGDTTTsGASDEED Serinc molecular association, regulation AP1M1(INDUCES); AP2M1(INDUCES) 30135209 1 1 0 Mu subunits of AP-1 and AP-2 fused to MBP -Plk2 PLK2 EC 2.7.11.21; KINASE; Kinase, protein; Protein kinase, Other; Protein kinase, Ser/Thr (non-receptor); Tumor suppressor Q9R012 83722 2q14 rat T236-p 25790901 PLEHRRRtICGTPNY Pkinase enzymatic activity, induced 20802490 2 0 1 -EFNB2 EFNB2 Ligand, receptor tyrosine kinase; Membrane protein, integral P52799 1948 13q33.3 human Y316-p 447830 GDYGHPVyIVQEMPP protein stabilization; protein conformation 12606549 3 9 121 -Rcan1 RCAN1 Inhibitor Q6IN33 266766 11q11 rat S108-p 456022 PDKQFLIsPPASPPV Calcipressin enzymatic activity, induced neural plasticity 32084406 7 34 5 induces calcineurin activity and hence LTD -Ppp2r5d PPP2R5D Motility/polarity/chemotaxis; PHOSPHATASE; Protein phosphatase, regulatory subunit Q7TNL5 21770 17 22.9 cM|17 C mouse S81-p 468499 VKKERRQsSFPFNLN enzymatic activity, induced 20106966 3 30 105 -Golga3 GOLGA3 Vesicle P55937 269682 5 F|5 53.36 cM mouse S174-p 487482 VKRHRERsSQPATKM apoptosis, altered 17888676 1 0 0 protected against Brefeldin-A-induced apoptosis, but not Fas-mediated apoptosis. -ACTB ACTB Cytoskeletal; Motility/polarity/chemotaxis P60709 60 7p22.1 human K284-sm 2894412 TTFNSIMkCDVDIRK Actin intracellular localization 19635839 1 1 0 nuclear localization -Hhex HHEX DNA-binding; Transcription factor F7F7Q9 rat S139-p 7430500 FETQKYLsPPERKRL Homeodomain cell cycle regulation; cell growth, induced 28927755 2 2 1 neointima formation ex vivo -SKAP1 SKAP55 Adaptor/scaffold; Motility/polarity/chemotaxis Q86WV1 8631 17q21.32 human Y295-p 460296 TRRKGVDyASYYQGL molecular association, regulation cell adhesion, altered; transcription, altered SLP76(DISRUPTS) 16461356 1 0 0 mutation of this site downregulates activity of IL-2 promoter and cytokine production -Bcl2l1 Bcl-xL Apoptosis; Autophagy; Membrane protein, integral; Mitochondrial P53563 24888 3q41 rat S62-p 449099 PSWHLADsPAVNGAT apoptosis, altered 18951975 18 1 0 -BUB1B BUB1B EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, Other; Protein kinase, Ser/Thr (non-receptor); Tumor suppressor O60566 701 15q15.1 human S670-p 3207630 TLSIKKLsPIIEDSR molecular association, regulation; phosphorylation cell cycle regulation; cytoskeletal reorganization PPP2R5A(INDUCES); PPP2CA(INDUCES) 19015317; 20016069; 23079597; 23345399; 33207204 9 35 0 pS670 Ab delayed anaphase onset in vivo and in vitro; regulates chromosome congression; chromosome segregation during mitosis and mitotic progression; T680 is independent of attachment status and may correlate with lack of interkinetochore tension.; regulates KNL1 phosphorylation; phosphorylated at kinetochores at the onset of mitosis; kinetochore-microtubule attachment -SCN5A SCN5A Channel, sodium; Membrane protein, integral; Membrane protein, multi-pass Q14524 6331 3p22.2 human S1934-p 40413914 LFRQQAGsGLSEEDA activity, induced; molecular association, regulation FGF13(DISRUPTS); Calmodulin(DISRUPTS) 28882890 3 3 0 impairs FGF13-dependent regulation of NaV1.5 channel inactivation -Ppp2r1a PPP2R1A Motility/polarity/chemotaxis; PHOSPHATASE; Protein phosphatase, regulatory subunit Q5XI34 117281 1q12 rat T268-p 31006103 YMVADKFtELQKAVG molecular association, regulation; protein conformation PPP2CA(DISRUPTS) 24465463 1 1 0 defect in holoenzyme assembly -Arhgap35 GRF-1 GAP; GAP, Rac/Rho; Motility/polarity/chemotaxis; Transcription factor; Tumor suppressor Q91YM2 232906 7|7 A2 mouse Y1105-p 448941 RNEEENIySVPHDST RhoGAP_pG1_pG2 molecular association, regulation RASA1(INDUCES) 9819392 5 83 3224 -PGR PR DNA-binding; Nuclear receptor; Transcription factor P06401 5241 11q22.1 human K531-sm 2890601 GYQAAVLkEGLPQVY Prog_receptor sumoylation; protein stabilization; intracellular localization; protein conformation transcription, inhibited 17020914 1 0 0 induces sumoylation at other sites -CLOCK CLOCK ACETYLTRANSFERASE; Acetyltransferase; DNA-binding; EC 2.3.1.48; Transcription factor O15516 9575 4q12 human S437-p 11087839 PSASSRSsRKSSHTA protein degradation 19946213 1 0 0 -Rara RARA DNA-binding; Nuclear receptor; Oncoprotein; Transcription factor P11416 19401 11 D|11 62.76 cM mouse K347-m3 2363104 QDLEQPDkVDMLQEP Hormone_recep molecular association, regulation transcription, induced RXRB(INDUCES); N-CoR1(INDUCES); RIP140(INDUCES); PCAF(INDUCES) 17205979 2 2 0 -Mknk1 Mnk1 EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, CAMK; Protein kinase, Ser/Thr (non-receptor); Translation O08605 17346 4|4 D1 mouse T344-p 447623 APERGLPtPQVLQRN enzymatic activity, induced translation, altered; cell growth, altered 18055695 3 4 14 -TOPORS TOPORS Cell cycle regulation; EC 6.3.2.-; EC 6.3.2.19; Ligase; SUMO LIGASE; SUMO conjugating system; SUMO ligase; UBIQUITIN LIGASE; Ubiquitin conjugating system; Ubiquitin ligase Q9NS56 10210 9p21.1 human T515-p 25756871 EKMETVKtQEQEQSY molecular association, regulation DNA repair, induced BRCA2(INDUCES) 35061896 1 0 1 RAD51 SUMOylation is required for HR-mediated DSB repair, GFP-TOPORS-WT restored the interaction between RAD51 and BRCA2, but the T515A mutant restored to a lesser degree -FOXO1 FOXO1A DNA-binding; Nuclear receptor co-regulator; Oncoprotein; Transcription factor Q12778 2308 13q14.11 human K262-ac 4253200 ASMDNNSkFAKSRSR molecular association, regulation; intracellular localization; phosphorylation carcinogenesis, inhibited; apoptosis, induced; transcription, inhibited DNA(DISRUPTS) 18786403; 20519497; 27132507 7 2 0 -H3C1 H3 DNA-binding P68431 8350 6p22.2 human S28-p 455677 ATKAARKsAPATGGV Histone molecular association, regulation; intracellular localization chromatin organization, altered; cell differentiation, induced; transcription, induced 14-3-3 zeta(INDUCES); HBXAP(DISRUPTS) 18418070; 20864036; 21282660; 21820363; 34635673 50 18 0 -Fos Fos DNA-binding; Motility/polarity/chemotaxis; Oncoprotein; Transcription factor P12841 314322 6q31 rat S374-p 448482 PSSDSLSsPTLLAL_ protein stabilization; protein conformation; phosphorylation cell cycle regulation; transcription, altered 12134156; 12629509; 17223854; 8622865 12 3 0 -DOK1 DOK1 Adaptor/scaffold; Motility/polarity/chemotaxis Q99704 1796 2p13.1 human S450-p 454885 SHNSALYsQVQKSGA cell motility, induced; cell growth, inhibited 15574499 1 0 2 -GAB1 GAB1 Adaptor/scaffold; Motility/polarity/chemotaxis Q13480 2549 4q31.21 human Y83-p 25655003 KKEFENSyIFDINTI PH cytoskeletal reorganization 22751113 2 0 0 -SGK1 SGK1 EC 2.7.11.1; KINASE; Kinase, protein; Motility/polarity/chemotaxis; Protein kinase, AGC; Protein kinase, Ser/Thr (non-receptor) O00141 6446 6q23.2 human S78-p 448430 ANPSPPPsPSQQINL cell cycle regulation 11254654 6 2 0 -KCNJ12 KCNJ12 Membrane protein, integral; Membrane protein, multi-pass Q14500 3768 17p11.2 human T38-p 3053610 FGNGKVHtRRRCRNR IRK_N activity, inhibited 12234954 1 0 0 -CFTR CFTR Channel, chloride; EC 3.6.3.49; Hydrolase; Membrane protein, integral; Membrane protein, multi-pass; Transporter; Transporter, ABC family P13569 1080 7q31.2 human S768-p 455300 LQARRRQsVLNLMTH CFTR_R activity, induced; molecular association, regulation; intracellular localization; enzymatic activity, inhibited; activity, inhibited 14-3-3 beta(INDUCES); CFTR(INDUCES) 14602047; 15657296; 19095655; 19328185; 19419994; 20952391; 26888287; 28242698 14 4 0 cell surface CFTR -Ppargc1a PGC-1 alpha Nuclear receptor co-regulator; Transcription, coactivator/corepressor O70343 19017 5|5 C1 mouse T177-p 486319 NHTHRIRtNPAIVKT transcription, altered 17609368 1 1 0 -Kcnq2 Kv7.2 Channel, potassium; Membrane protein, integral; Membrane protein, multi-pass O88943 170848 3q43 rat T217-p 457689 RMDRRGGtWKLLGSV Ion_trans; TM activity, induced 12754513 3 1 0 Mutants showed reduced currents induced by acetylcholine. -PAX3/FOXO1 PAX3-FOXO1 AAC50053 2308 13q14.11 human S437-p 38489513 SPRRRAAsMDNNSKF protein stabilization 31888889 1 1 11 -Pdlim4 RIL Cytoskeletal P70271 30794 11 B1.3|11 32.13 cM mouse S119-p 468635 PATSRRSsVSGISLE cell growth, inhibited 21644927 2 29 10 -CSNK1A1 CK1A EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, CK1; Protein kinase, Ser/Thr (non-receptor) P48729 1452 5q32 human S242-p 11333101 KISEKKMsTPVEVLC Pkinase molecular association, regulation 14-3-3 eta(INDUCES) 19860830 1 0 0 -Prkcd PKCD EC 2.7.11.13; KINASE; Kinase, protein; Nuclear receptor co-regulator; Protein kinase, AGC; Protein kinase, Ser/Thr (non-receptor); Protein kinase, tyrosine (non-receptor); Tumor suppressor P28867 18753 14 B|14 18.82 cM mouse S662-p 447580 QEAFHGFsFVNPKFE Pkinase_C intracellular localization 15731106 11 59 76 -Rab3ip RAB3IP GEF; GEF, Rab Q62739 29885 7q22 rat S250-p 482771 VLSSSPTsPTQEPLA Sec2p activity, induced; molecular association, regulation; protein conformation; enzymatic activity, induced exocytosis, induced RAB11A(DISRUPTS); RAB8A(INDUCES) 25535387 1 16 1 induces GEF activity of RAB3IP, induces RAB8 activity -BIRC5 Survivin Apoptosis O15392 332 17q25.3 human K129-ac 25558401 KEFEETAkKVRRAIE molecular association, regulation; intracellular localization STAT3(INDUCES); Survivin(INDUCES); Exportin-1(DISRUPTS) 20826784; 28384094 2 1 0 -SNAP25 SNAP-25 Vesicle P60880 6616 20p12.2 human T29-p 23939101 ADESLEStRRMLQLV exocytosis, induced 22311984 2 3 0 -Rps6kb1 p70S6K iso2 EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, AGC; Protein kinase, Ser/Thr (non-receptor); Translation P67999-2 83840 10q26 rat T421-p 448358 RFIGSPRtPVSPVKF activity, induced cell growth, altered 16195541 106 37 109 PI3K, Akt and mTOR activation are required for 5-HT-induced proliferatioin. Wortmanin LY294002 and NL-71-101 dose-dependently inhibited 5HT induced proliferation. -HNRNPUL1 E1B-AP5 RNA splicing; RNA-binding Q9BUJ2 11100 19q13.2 human R645-m1 12191850 NRGGFQNrGGGSGGG molecular association, regulation; intracellular localization NBS1(INDUCES) 26020839 1 5 25 ecruitment at sites of damage -SESN2 SESN2 P58004 83667 1p35.3 human S254-p 1869992400 NNSGGFEsARDVEAL PA26 molecular association, regulation; intracellular localization autophagy, induced ATP5A1(INDUCES) 32854424 1 1 0 -XRCC6 Ku70 DNA repair, damage; DNA-binding; EC 3.6.4.-; EC 4.2.99.-; Helicase; Nuclear receptor co-regulator; RNA-binding P12956 2547 22q13.2 human K542-ac 458922 NPEGKVTkRKHDNEG Ku_C molecular association, regulation; intracellular localization cell growth, induced; apoptosis, induced; apoptosis, inhibited BAX(INDUCES); BAX(DISRUPTS) DNA(DISRUPTS) 15023334; 17545612; 28238784 3 1 0 -IKBKE IKKE EC 2.7.11.10; Inhibitor; KINASE; Kinase, protein; Protein kinase, Other; Protein kinase, Ser/Thr (non-receptor) Q14164 9641 1q32.1 human T501-p 34434402 ELRSRLRtLAEVLSR TBK1_CCD1 phosphorylation; enzymatic activity, induced signaling pathway regulation 24882218 1 0 0 IFN signaling -PGR PR DNA-binding; Nuclear receptor; Transcription factor P06401 5241 11q22.1 human S190-p 447986 KVLPRGLsPARQLLL Prog_receptor transcription, induced 8662865 6 2 0 -ASAP3 DDEFL1 GAP; GAP, ARF; Motility/polarity/chemotaxis Q8TDY4 55616 1p36.12 human Y34-p 28704100 FAAKMPRyRGAALAR BAR_3 intracellular localization; protein conformation; enzymatic activity, induced cell motility, induced; cytoskeletal reorganization; signaling pathway regulation 23776207 1 1 0 EGF signaling pathway -CENPT CENPT DNA replication Q96BT3 80152 16q22.1 human T27-p 472114 LDTADPRtPRRPRSA CENP-T_N intracellular localization cell cycle regulation 21529714 2 6 35 localization of Ndc80/Hec1, controls kinetochore assembly, increases cell viability -CD93 CD93 Cell adhesion; Membrane protein, integral Q9NPY3 22918 20p11.21 human Y628-p 1031156 PQNAADSySWVPERA molecular association, regulation cell motility, induced; cell adhesion, induced CBL(INDUCES) 26848865 1 2 1 CD93 binds to Cbl inducing phosphorylation on tyrosine 774 of CBL -KCNA3 Kv1.3 Channel, potassium; Membrane protein, integral; Membrane protein, multi-pass P22001 3738 1p13.3 human Y499-p 451294 EGEEQSQyMHVGSCQ activity, induced; activity, inhibited cell growth, induced 11812778; 19166614; 26655221 3 0 0 -IRF2BP2 IRF2BP2 Transcription, coactivator/corepressor Q7Z5L9 359948 1q42.3 human S360-p 470316 TARKRKPsPEPEGEV activity, induced; intracellular localization 21887377 1 71 0 nuclear localization -GBF1 GBF1 GEF; GEF, ARF Q92538 8729 10q24.32 human Y899-p 34551124 TGLVRENyVWNVLLH molecular association, regulation; intracellular localization; protein conformation ARF1(INDUCES) 34870592 1 1 2 induces GALNT relocation -Olig1 OLIG1 Cell development/differentiation; Transcription factor Q9JKN5 50914 16|16 C3.3 mouse S138-p 25602100 GAPGRKLsKIATLLL HLH intracellular localization cell growth, induced; cell differentiation, induced 22639060 1 0 0 -TBXA2R TXA2-R GPCR, family 1; Membrane protein, integral; Membrane protein, multi-pass; Receptor, GPCR P21731 6915 19p13.3 human S324-p 3061802 RRLQPRLsTRPRSLS molecular association, regulation; activity, inhibited 24490858 2 0 0 desensitization of thromboxane receptor to agonist binding -MAP4 MAP4 Cytoskeletal; Motility/polarity/chemotaxis P27816 4134 3p21.31 human K998-ac 62495520 KVQIVSKkVSYSHIQ Tubulin-binding cytoskeletal reorganization 28002468 1 1 0 -Ank3 ANK3 iso4 Adaptor/scaffold; Motility/polarity/chemotaxis XP_006513193 11735 10 B5.3|10 36.1 cM mouse S1982-p 15718927 PKSDKGHsPEDDWTE molecular association, regulation; protein conformation neural plasticity; signaling pathway regulation SPTBN4(INDUCES) 31451636 1 4 0 targeting of SPTBN4 into the palasma membrane is reduced in S1982A mutatnt -GJA8 GJA8 Channel, misc.; Membrane protein, integral; Membrane protein, multi-pass P36381 395846 chicken S364-p 465560 KAEEEVVsDEVEGPS protein degradation; protein stabilization 10702244; 18649174 2 1 0 phosphorylation of this site blocks Cx50 from the cleavage by caspase-3 -CSF3R GCSFR Membrane protein, integral; Receptor, cytokine Q99062 1441 1p34.3 human K655-ub 9381807 LCCSPNRkNPLWPSV protein degradation; receptor internalization, induced; intracellular localization; phosphorylation cell growth, inhibited; cell growth, induced; cell differentiation, induced; signaling pathway regulation 17363902; 19453968 2 0 0 regulates production of neutrophilic granulocytes, regulates STAT5 activation; inhibits STAT5 activation -NF2 Merlin Cytoskeletal; Motility/polarity/chemotaxis; Tumor suppressor P35240 4771 22q12.2 human S518-p 448282 DTDMKRLsMEIEKEK ERM_C molecular association, regulation; ubiquitination; intracellular localization; protein conformation; activity, inhibited; phosphorylation cell cycle regulation; carcinogenesis, induced; transcription, altered; cell growth, induced; cell motility, altered; cytoskeletal reorganization; cell adhesion, altered; cell growth, altered DDB1(DISRUPTS); CD44(DISRUPTS); Merlin(DISRUPTS); AMOT(DISRUPTS); SPTAN1(INDUCES); LIN28B(DISRUPTS); TUBA4A(DISRUPTS); PIK3R2(DISRUPTS); VPRBP(INDUCES); 53BP2(DISRUPTS); Merlin(INDUCES); YAP1(DISRUPTS); Ezrin(INDUCES); Src(DISRUPTS); MED28(DISRUPTS); Hrs(DISRUPTS); VPRBP(DISRUPTS); LRP6(DISRUPTS); LATS1(INDUCES) 11703924; 11782491; 14724586; 14981079; 15378014; 15743831; 16267393; 16652148; 17175165; 17566081; 18071304; 18835652; 20178741; 21750658; 22516197; 25925953; 26997273; 27285107; 33058421; 36809290 33 41 1 cell-cell contact dephosphorylates; phosphorylation of this site increases intramolecular association of the N-terminal (FERM) domain with the C-terminal tail- in vitro data; increases phosphorylation of S10; inhibits ubiquitination and LATS1/YAP/TAZ phosphorylation -KLF16 KLF16 C2H2-type zinc finger protein; DNA-binding Q9BXK1 83855 19p13.3 human Y10-p 22874704 AAVACVDyFAADVLM activity, induced transcription, inhibited SIN3A(INDUCES) 22203677 1 0 0 -ARHGEF2 ARHGEF2 GEF; GEF, Rac/Rho; Motility/polarity/chemotaxis Q92974 9181 1q22 human S143-p 10991696 GSRRGRSsLSLAKSV molecular association, regulation; intracellular localization cytoskeletal reorganization TUBB2B(DISRUPTS) 21513698 2 7 4 inhibits microtubule binding and stabilization, acetylation, regulates cell polarization -Piwil2 PIWIL2 Apoptosis; Cancer Testis Antigen (CTA) Q8CDG1 57746 14|14 D2 mouse R74-m1 9859904 VGLVSMFrGMGLDTA molecular association, regulation; intracellular localization TDRKH(INDUCES); TDRD9(INDUCES); TDRD1(INDUCES) 19584108 1 1 1 -Ripk3 RIPK3 EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, Ser/Thr (non-receptor); Protein kinase, TKL Q9QZL0 56532 14|14 C3 mouse S232-p 23003800 AELVDKTsLIRETVC Pkinase activity, induced; molecular association, regulation; intracellular localization; protein conformation; enzymatic activity, induced; phosphorylation apoptosis, induced; apoptosis, inhibited ZBP1(INDUCES); MLKL(INDUCES) 23612963; 24902902; 25459880; 26283397; 27819681; 31511692; 33206046; 35580168; 35648750 25 7 0 -SMURF2 SMURF2 EC 6.3.2.-; EC 6.3.2.19; Ligase; UBIQUITIN LIGASE; Ubiquitin conjugating system; Ubiquitin ligase Q9HAU4 64750 17q23.3-q24.1 human T249-p 27457334 MSRTHLHtPPDLPEG ubiquitination carcinogenesis, inhibited; signaling pathway regulation 35017630 2 2 0 induces TGFBR1 ubiquitination and degradation, thus regulating the TGF-?-SMAD2/3 pathway -Grin2a NMDAR2A Channel, ligand-gated; Membrane protein, integral; Membrane protein, multi-pass P35436 14811 16 A1|16 5.28 cM mouse S1462-p 3597310 KKMPSIEsDV_____ NMDAR2_C molecular association, regulation PSD-95(NOT_REPORTED) 17179037 1 2 0 effects PKC potentiation of current -P2RX3 P2X3 Channel, ligand-gated; Membrane protein, integral; Membrane protein, multi-pass P56373 5024 11q12.1 human T196-p 458893 GNLLPNLtARDMKTC P2X_receptor receptor desensitization, altered 16226373 1 0 1 -RELA NFkB-p65 DNA-binding; Nuclear receptor co-regulator; Transcription factor Q04206 5970 11q13.1 human K314-ub 25087017 ETFKSIMkKSPFSGP transcription, inhibited 21706061 1 1 0 inhibits acetylation -CERS2 LASS2 DNA-binding; Membrane protein, integral; Membrane protein, multi-pass; Transferase Q96G23 29956 1q21.3 human S248-p 1872840300 SSDYLLEsAKMFNYA TRAM_LAG1_CLN8 carcinogenesis, inhibited; signaling pathway regulation 33852174 1 0 0 LASS2 S248A mutant inhibits ?-catenin ubiquitination and degradation and inhibits Wnt/?-catenin signaling pathway -IRAK1 IRAK1 EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, Ser/Thr (non-receptor); Protein kinase, TKL P51617 3654 Xq28 human S173-p 21041601 SLWPPPPsPAPSSTK molecular association, regulation; enzymatic activity, induced transcription, induced PIN1(INDUCES) 21743479; 27790836 2 0 0 -SRPK1 SRPK1 EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, CMGC; Protein kinase, Ser/Thr (non-receptor) Q96SB4 6732 6p21.31 human S587-p 25724400 LIVAGKYsKEFFTKK Pkinase intracellular localization RNA splicing, induced 22727668 1 1 0 translocation to the nucleus-regulation of E1A splicing -FIS1 FIS1 Membrane protein, integral; Mitochondrial Q9Y3D6 51024 7q22.1 human K149-sm 1883432306 LIGLAVSkSKS____ intracellular localization 34994490 1 0 0 more likely to localize to areas of the cell in which ER islocalized, SENP3-mediated deSUMOylation of Fis1 is required for mitophagy -Slc12a1 NKCC2 Membrane protein, integral; Membrane protein, multi-pass; Transporter; Transporter, SLC family P55014 20495 2 F1|2 61.23 cM mouse S126-p 478420 GPKVNRPsLLEIHEQ AA_permease_N activity, induced 17341212; 24808538 8 2 0 -Nbn NBS1 Cell cycle regulation; DNA repair, damage Q9R207 27354 4|4 A2 mouse S433-p 483547 KTPSYQLsPMKFPVA molecular association, regulation; intracellular localization carcinogenesis, induced; DNA repair, altered TRF2(DISRUPTS) 28216226; 34145035 4 40 0 -Epha3 EphA3 EC 2.7.10.1; KINASE; Kinase, protein; Membrane protein, integral; Protein kinase, TK; Protein kinase, tyrosine (receptor) P29319 13837 16|16 C1.3 mouse Y596-p 449912 KLPGLRTyVDPHTYE EphA2_TM enzymatic activity, induced 20697431 3 6 26 -ITK ITK EC 2.7.10.2; KINASE; Kinase, protein; Protein kinase, TK; Protein kinase, tyrosine (non-receptor) Q08881 3702 5q33.3 human Y512-p 447997 RFVLDDQyTSSTGTK PK_Tyr_Ser-Thr activity, induced; phosphorylation; enzymatic activity, induced signaling pathway regulation 31196981; 9312162 3 8 260 autophosphorylation at Y180 -CD36 CD36 Cell adhesion; Membrane protein, integral; Membrane protein, multi-pass P16671 948 7q21.11 human K472-ub 2363101 ACRSKTIk_______ protein degradation; molecular association, regulation; ubiquitination IRS1(INDUCES) 18316598; 29269414 2 0 0 inhibits insulin-stimulated IRS1 degradation, disrupts IRS1 interaction with CUL7 and Fyn, regulates IRS1 ubiquitination -MAPK14 P38A EC 2.7.11.24; KINASE; Kinase, protein; Protein kinase, CMGC; Protein kinase, Ser/Thr (non-receptor) Q16539 1432 6p21.31 human R49-me 1877038904 FDTKTGLrVAVKKLS Pkinase molecular association, regulation; phosphorylation; enzymatic activity, induced cell differentiation, induced MAPKAPK2(INDUCES); MKK3(INDUCES) 32429593 1 1 0 augments phosphorylation by MKK3 and enhances the activation of p38-alpha -PDZK1 PDZK1 Adaptor/scaffold Q5T2W1 5174 1q21.1 human S505-p 456807 MAKERAHsTASHSSS molecular association, regulation cell motility, induced; cell growth, induced PTGIR(INDUCES) 21653824 2 2 1 increases cell surface expression of functional PTGIR (aka hIP) leading to enhanced ligand binding and cAMP generation, increases endothelial cell migration and angiogenesis (tube formation) -OSBP2 OSBP2 Q969R2 23762 22q12.2 human S762-p 11171320 ECSKVMHsSPSSPSS Oxysterol_BP molecular association, regulation; protein conformation signaling pathway regulation Vimentin(INDUCES) 30925160 1 1 6 -EPHA2 EphA2 EC 2.7.10.1; KINASE; Kinase, protein; Membrane protein, integral; Protein kinase, TK; Protein kinase, tyrosine (receptor) P29317 1969 1p36.13 human S897-p 1244153 RVSIRLPsTSGSEGV receptor internalization, induced; protein stabilization; molecular association, regulation; intracellular localization; phosphorylation carcinogenesis, induced; cell motility, induced; signaling pathway regulation; DNA repair, induced; endocytosis, induced; cell growth, induced; apoptosis, inhibited; cell motility, altered; cytoskeletal reorganization DNAPK(INDUCES); ephexin-1(INDUCES); EGFR(INDUCES) 19573808; 25908849; 26158630; 33671073; 33907562; 34006609; 34018641; 34445353; 34484860; 35110502; 35668076; 36998455; 37063424; 37179400 25 32 171 induces chemoresistance; induces ERK and MDM2 phosphorylation, induces p53 degradation through the ERK/MDM2 pathway -Kcnn4 KCNN4 Channel, potassium; Membrane protein, integral; Membrane protein, multi-pass Q9QYW1 65206 1q21 rat S312-p 452143 YAKEMKEsAARLLQE CaMBD activity, inhibited 15243742 1 0 0 -ITGB4 ITGB4 Cell adhesion; Membrane protein, integral; Motility/polarity/chemotaxis; Receptor, misc. P16144 3691 17q25.1 human S1364-p 451655 PSGSQRPsVSDDTGC molecular association, regulation cell motility, altered; cytoskeletal reorganization Plectin-1(DISRUPTS) 17615294; 20870721 5 2 3 -STAT3 STAT3 DNA-binding; Motility/polarity/chemotaxis; Nuclear receptor co-regulator; Transcription factor P40763 6774 17q21.2 human K180-ub 10838906 DFNYKTLkSQGDMQD STAT_alpha phosphorylation 30741923 1 8 5 Hectd3-mediated polyubiquitination of Stat3 induces activating phosphorylation at Y705 and generation of ROR?t+IL17hi Th17 cells. -TP53 p53 Activator; DNA-binding; Motility/polarity/chemotaxis; Nuclear receptor co-regulator; Transcription factor; Tumor suppressor P04637 7157 17p13.1 human K120-ac 474514 FLHSGTAkSVTCTYS P53 activity, induced; acetylation; protein stabilization; molecular association, regulation; intracellular localization cell cycle regulation; apoptosis, altered; carcinogenesis, inhibited; cell growth, inhibited; apoptosis, induced; transcription, induced; signaling pathway regulation; transcription, altered; cell differentiation, induced; DNA repair, inhibited MDM2(DISRUPTS); DDX5(INDUCES) DNA(INDUCES) 17189187; 18485870; 19339993; 19377469; 19416725; 19494119; 19854137; 21148320; 21297583; 21303901; 21463657; 21525412; 22084066; 23431171; 23576563; 23677994; 24038750; 24120667; 24207022; 24219989; 25544752; 25961455; 26851285; 26882543; 27050276; 27208501; 28737768; 30940656; 31395738; 31680191; 32031738; 33789902; 35534985; 35872650 44 8 0 decrease of K120 acetylation shifts the balance from a proapoptotic pathway and induces p21 expression; HDAC6 ablation induces senescence p21 expression and inhibits cell growth, HDAC6 ablation inhibits HC proliferation after two-thirds partial hepatectomy (PHx); recruit p300, CBP, and TIP60 onto PD-1 promoter, p53-mediated PD-1 transcription; RNF8 promotes DSB repair and inhibits the pro-apoptotic activity and promotes DNA repair. ; 20, 164, 305, 320, 370/372/373, 381/382/386 K-R mutants diminsished transactivation, and selective regulation of target genes expression through distinct mechanisms; Increased p53 acetylation and apoptosis in the Ndufs4-deficient brain; iASPP displacement of p53 could affect acetylation of p53 and target gene selecivity -AXIN1 axin 1 Adaptor/scaffold; Tumor suppressor O15169 8312 16p13.3 human S75-p 4697306 LGYEPEGsASPTPPY AXIN1_TNKS_BD transcription, inhibited GSK3B(INDUCES) 17318175 1 11 20 -Pms2 PMS2 Cell cycle regulation; DNA repair, damage; EC 3.1.-.-; Hydrolase; Tumor suppressor P54279 18861 5 82.82 cM|5 G2 mouse T337-p 1881225900 ECVDINVtPDKRQIL molecular association, regulation MLH1(INDUCES) 36952545 1 0 0 -PRKCD PKCD EC 2.7.11.13; KINASE; Kinase, protein; Nuclear receptor co-regulator; Protein kinase, AGC; Protein kinase, Ser/Thr (non-receptor); Protein kinase, tyrosine (non-receptor); Tumor suppressor Q05655 5580 3p21.1 human S299-p 483986 NQVTQRAsRRSDSAS intracellular localization 17603046 1 18 21 localizes to the plasma and nuclear membrane -BACE1 BACE EC 3.4.23.46; Membrane protein, integral; Protease P56817 23621 11q23.3 human K501-ub 14991108 ADDISLLk_______ protein degradation; intracellular localization 20484053; 23109336; 27302062 3 0 0 -Prkaa2 AMPKA2 Autophagy; EC 2.7.11.1; EC 2.7.11.27; EC 2.7.11.31; KINASE; Kinase, protein; Protein kinase, CAMK; Protein kinase, Ser/Thr (non-receptor) Q8BRK8 108079 4|4 C6 mouse T172-p 448026 SDGEFLRtSCGSPNY Pkinase protein degradation; intracellular localization; phosphorylation; enzymatic activity, induced cell differentiation, inhibited; carcinogenesis, induced; carcinogenesis, inhibited; cell motility, induced; cell growth, inhibited; cell motility, inhibited; transcription, induced; signaling pathway regulation; transcription, altered; autophagy, induced; apoptosis, inhibited; autophagy, inhibited; cytoskeletal reorganization; transcription, inhibited 15866171; 17420279; 26091038; 28179583; 31930700; 31970902; 32051584; 32154661; 33516941; 33613155; 33779513; 33819291; 33869980; 33930463; 34006524; 34040167; 34493662; 34497121; 34588305; 34687898; 35061665; 35115380; 36715635 220 13 33 -NOS3 eNOS Amino Acid Metabolism - arginine and proline; EC 1.14.13.39; Oxidoreductase P29474 4846 7q36.1 human S114-p 448638 RKLQGRPsPGPPAPE molecular association, regulation; intracellular localization; enzymatic activity, induced ERK2(DISRUPTS) 16270749; 20213743; 35182051 22 4 0 -VIL1 Villin Actin-binding; Motility/polarity/chemotaxis P09327 7429 2q35 human Y64-p 3176603 SLSYDIHyWIGQDSS Gelsolin cytoskeletal reorganization 12269817 1 0 0 -Ppargc1a PGC-1 alpha Nuclear receptor co-regulator; Transcription, coactivator/corepressor O70343 19017 5|5 C1 mouse S615-p 15422176 RHRTHRNsPLYVRSR protein stabilization 23201126 1 0 3 -KEAP1 KEAP1 Endoplasmic reticulum; Motility/polarity/chemotaxis; Transcription regulation; UBIQUITIN LIGASE; Ubiquitin conjugating system Q14145 9817 19p13.2 human K551-ub 1883516302 WTFVAPMkHRRSALG protein degradation 36163178 1 0 0 -RAD17 RAD17 Cell cycle regulation O75943 5884 5q13.2 human S646-p 447755 ETWSLPLsQNSASEL molecular association, regulation; phosphorylation cell cycle regulation; cell growth, altered RAD1(INDUCES); SMG7(INDUCES); claspin(INDUCES) 11418864; 11687627; 16885023; 33820915 9 0 0 -RBM8A RBM8A RNA splicing; RNA-binding; Spliceosome; Translation Q9Y5S9 9939 1q21.1 human S166-p 456534 RRGGRRRsRSPDRRR molecular association, regulation RNA splicing, altered UPF3B(DISRUPTS); NCBP1(DISRUPTS); THOC4(DISRUPTS); TAP(DISRUPTS); RPL22(DISRUPTS) 16100109 2 8 3 Phosphorylation is required for release downstream factors. Phosphorylation interferes with RBM8A's arginine methylation in vitro (by rat PRMT1) and in vivo. -CHRM2 mAChR M2 GPCR, family 1; Membrane protein, integral; Membrane protein, multi-pass; Receptor, GPCR P08172 1129 7q33 human S309-p 459107 TQDENTVsTSLGHSK 7tm_1 receptor desensitization, altered; receptor internalization, altered 9162044 3 0 0 Mutation of 4 S/T to A eliminates receptor desensitization in response to carbachol treatment (as measured by isoproterenol-stimulated cAMP production after pretreatment with carbachol).; Mutation of S286 T287 S288 S290 to A caused a faster rate and a greater extent of receptor internalization after agonist stimulation (transients only, not observed in stables). Mutation of all 8 sites prevented internalization (in both transients and stables). -ERBB2 HER2 EC 2.7.10.1; KINASE; Kinase, protein; Membrane protein, integral; Oncoprotein; Protein kinase, TK; Protein kinase, tyrosine (receptor) P04626 2064 17q12 human S1151-p 3178974 DVRPQPPsPREGPLP carcinogenesis, induced; transcription, induced; signaling pathway regulation 35637411 1 8 45 induces the PI3K/AKT/NFkB p65 pathway -Myh9 MYH9 Actin-binding; Motility/polarity/chemotaxis; Motor Q8VDD5 17886 15 E1|15 36.81 cM mouse S1916-p 451181 AMNREVSsLKNKLRR Myosin_tail_1 exocytosis, induced; cell motility, induced; cytoskeletal reorganization 22025714; 35764499 11 3 8 -Cttn Cortactin Actin-binding; Cytoskeletal; Motility/polarity/chemotaxis Q60598 13043 7|7 F5 mouse Y541-p 13261767 YGLFPANyVELRQ__ SH3_9 molecular association, regulation MTUS2(DISRUPTS) 27451391 1 2 20 Y497, Y499, Y541 are major residues for interaction -MAP3K11 MLK3 EC 2.7.11.25; KINASE; Kinase, protein; Protein kinase, Ser/Thr (non-receptor); Protein kinase, TKL Q16584 4296 11q13.1 human S548-p 4269787 GQAWGRQsPRRLEDS enzymatic activity, inhibited; phosphorylation cell cycle regulation; carcinogenesis, inhibited; cell growth, inhibited 35843311 1 8 0 inhibits JNK and SEK1 phosphorylation -DNMT1 DNMT1 Amino Acid Metabolism - cysteine and methionine; Cell development/differentiation; EC 2.1.1.37; METHYLTRANSFERASE; Methyltransferase; Methyltransferase, DNA; Transcription regulation P26358 1786 19p13.2 human S154-p 476108 AKPEPSPsPRITRKS acetylation; protein stabilization; enzymatic activity, induced transcription, altered 21565170; 35246513 3 28 4 decreased stability in 154A mutant after treatment with 5'-Aza-2-Deoxycytidine; regulates MRTF-A acetylation -DGCR8 DGCR8 Nucleolus; RNA processing; RNA-binding Q8WYQ5 54487 22q11.21 human S493-p 25735895 NQKLITLsVQDAPTK protein stabilization 24239349 0 1 1 -Rigi RIGI EC 3.6.4.13; Hydrolase Q6Q899 230073 4|4 A5 mouse K146-m1 1883825701 IRQIRDTkGRMAGAE CARD_2 molecular association, regulation carcinogenesis, induced; signaling pathway regulation AMPKA1(INDUCES); STAT3(DISRUPTS) 36333807 1 1 0 RIGI demethylation inhibited IL-6-STAT3 signaling; demethylation of RIG-I to enhances RIGI-STAT3 association; JMJD4 and RIGI co-operatively inhibit DEN-induced hepatocarcinogenesis and steatosis; methylated RIG-I associates with AMPKA1 to inhibit HMGCR phosphorylation and promote cholesterol synthesis and NAFLD progression -Prkcd PKCD EC 2.7.11.13; KINASE; Kinase, protein; Nuclear receptor co-regulator; Protein kinase, AGC; Protein kinase, Ser/Thr (non-receptor); Protein kinase, tyrosine (non-receptor); Tumor suppressor P09215 170538 16p16 rat Y155-p 447575 IKQAKIHyIKNHEFI intracellular localization; phosphorylation apoptosis, induced 24569990 11 0 0 -FOXL2 FOXL2 DNA-binding; Transcription factor P58012 668 3q22.3 human K124-ac 1876739201 REGGGERkGNYWTLD Forkhead molecular association, regulation cell cycle regulation Ku80(INDUCES); Ku70(INDUCES) 32332759 1 1 0 Sequestering of XRCC5/6 by acetylated FOXL2 during G2 allows HR to occur preferentially over NHEJ -SAMHD1 SAMHD1 EC 3.1.4.- Q9Y3Z3 25939 20q11.23 human K595-sm 580826984 APLITPQkKEWNDST enzymatic activity, induced 34321470 1 2 0 SUMOylation of K595 is required for SAMHD1 to be antivirally active. -NFAT5 NFAT5 Transcription factor O94916 10725 16q22.1 human S158-p 2715403 LLDNSRMsCQDEGCG intracellular localization 18411282 2 2 0 -CDC25B CDC25B iso2 EC 3.1.3.48; Motility/polarity/chemotaxis; Nuclear receptor co-regulator; PHOSPHATASE; Protein phosphatase, dual-specificity P30305-2 994 20p13 human S103-p 9819903 GLCMDSPsPMDPHMA M-inducer_phosp protein degradation; ubiquitination 21807946 2 0 0 -VIPAS39 VIPAS39 Vesicle Q9H9C1 63894 14q24.3 human Y11-p 449005 TKGDEEEyWNSSKFK protein degradation; molecular association, regulation VPS33B(DISRUPTS) 22677173 1 8 320 -TBL1XR1 TBL1XR1 Nuclear receptor co-regulator; Transcription, coactivator/corepressor Q9BZK7 79718 3q26.32 human T203-p 2509602 WNLSENStSGSTQLV transcription, induced 18374649 1 0 0 -MDM2 MDM2 EC 6.3.2.-; EC 6.3.2.19; Inhibitor; Ligase; NEDDYLATION LIGASE; Neddylation Ligase; Nucleolus; Oncoprotein; UBIQUITIN LIGASE; Ubiquitin conjugating system; Ubiquitin ligase Q00987 4193 12q15 human S269-p 455458 SEEGQELsDEDDEVY molecular association, regulation cell growth, altered Rb(DISRUPTS) RNA(DISRUPTS) 15703839 3 1 0 decreases ability to bind poly-G RNA -Ets1 Ets-1 DNA-binding; Motility/polarity/chemotaxis; Oncoprotein; Transcription factor P27577 23871 9 A4|9 17.97 cM mouse S257-p 449319 DSFESVEsYDSCDRL Ets1_N_flank molecular association, regulation; acetylation; intracellular localization transcription, inhibited DNA(DISRUPTS) 30865889 4 0 1 induce acetylation of FOXO1 and suppress gluconeogenesis -STMN3 STMN3 Cytoskeletal Q9NZ72 50861 20q13.33 human S60-p 4698871 SFEVILKsPSDLSPE Stathmin intracellular localization cytoskeletal reorganization 22577147 2 4 0 -AURKA AurA EC 2.7.11.1; KINASE; Kinase, protein; Oncoprotein; Protein kinase, Other; Protein kinase, Ser/Thr (non-receptor) O14965 6790 20q13.2 human T288-p 448784 APSSRRTtLCGTLDY Pkinase intracellular localization; protein conformation; phosphorylation; enzymatic activity, induced cell cycle regulation; carcinogenesis, induced; autophagy, induced; cell motility, induced; apoptosis, inhibited; cytoskeletal reorganization 15173575; 16082213; 16246726; 16785988; 17545617; 20603326; 22094468; 23924325; 26165940; 27242098; 27721411; 31154600; 33744274; 33760847; 33771996; 33805672; 36372230 66 12 7 -NFKB2 NFkB-p100 DNA-binding; Oncoprotein; Transcription factor Q00653 4791 10q24.32 human S870-p 450167 KEDSAYGsQSVEQEA molecular association, regulation; protein processing IKKA(INDUCES); BTRC(INDUCES) 11239468; 15310758; 22388891 7 1 1 -Kif23 KIF23 Microtubule-binding; Motility/polarity/chemotaxis; Motor E9Q5G3 71819 9|9 B mouse S807-p 470674 VRHRRSRsAGSRWVD MKLP1_Arf_bdg intracellular localization cell cycle regulation; cytoskeletal reorganization 15199097 5 7 0 regulates cytokinesis -Slc10a2 ASBT Membrane protein, integral; Membrane protein, multi-pass; Transporter Q62633 29500 16q12.5 rat T339-p 453446 PMPSFQEtNKGFQPD protein degradation 15304498 2 0 0 -CDKL5 CDKL5 Cell cycle regulation; EC 2.7.11.22; KINASE; Kinase, protein; Protein kinase, CMGC; Protein kinase, Ser/Thr (non-receptor) O76039 6792 Xp22.13 human S308-p 15719610 RLLDRSPsRSAKRKP intracellular localization 27840050 1 2 0 cytoplasmic localization -Cacng2 Stargazin Channel, calcium; Membrane protein, integral; Membrane protein, multi-pass Q71RJ2 84347 7q34 rat S228-p 455313 SAITRIPsYRYRYQR molecular association, regulation neural plasticity PSD-95(INDUCES) 25843401 5 1 2 -AGER RAGE Cell cycle regulation; Membrane protein, integral; Motility/polarity/chemotaxis; Receptor, misc. Q15109 177 6p21.32 human S391-p 4731275 ERAELNQsEEPEAGE molecular association, regulation; protein conformation; phosphorylation DNA repair, induced; apoptosis, induced; signaling pathway regulation IRAK4(INDUCES); TIRAP(INDUCES); MYD88(INDUCES) 21829704; 25002577; 28977635 4 2 0 -PFKFB3 PFKFB3 Carbohydrate Metabolism - fructose and mannose; EC 2.7.1.105; EC 3.1.3.46; KINASE; Kinase, other; Motility/polarity/chemotaxis; PHOSPHATASE; Phosphatase (non-protein) Q16875 5209 10p15.1 human T463-p 468407 LMRRNSVtPLASPEP cell growth, induced 29967256 1 17 2 CDK6 phosphorylation of PFKFB3 may regulate glucose metabolism and be involved in breast cancer -Atp1a1 ATP1A1 EC 3.6.3.9; Hydrolase; Membrane protein, integral; Membrane protein, multi-pass; Transporter; Transporter, ion channel P06685 24211 2q34 rat Y542-p 458467 KDAFQNAyLELGGLG enzymatic activity, induced exocytosis, altered AP-2 alpha(DISRUPTS) 11859087 1 8 143 -ACADVL ACADVL EC 1.3.8.9; Lipid Metabolism - fatty acid; Mitochondrial; Oxidoreductase P49748 37 17p13.1 human K507-ac 40477505 LLLGEAGkQLRRRAG molecular association, regulation CRLS1(INDUCES) 25811481 1 0 0 both SIRT3 and SIRT5 KO show reduced afinity for CRLS1 -HMGA1 HMGA1 DNA-binding P17096 3159 6p21.31 human S36-p 455950 PRKQPPVsPGTALVG molecular association, regulation DNA(INDUCES) 17960875 2 50 19 Cdc2 phosphorylated HMGA1 has lower binding affinity than HIPK2 phosphorylated HMGA1. -CDT1 CDT1 DNA replication; DNA-binding; Motility/polarity/chemotaxis; Oncoprotein Q9H211 81620 16q24.3 human T358-p 1239966007 PPATEKLtTAQEVLA cell cycle regulation; cytoskeletal reorganization 30154187 1 1 0 regulates kTM stability -FN1 FN1 iso1 Cell adhesion; Motility/polarity/chemotaxis; Secreted; Secreted, signal peptide P02751-1 2335 2q35 human S2384-p 467903 VQADREDsRE_____ cell adhesion, induced 31291285 1 29 26 -ARRB2 ARRB2 iso2 Adaptor/scaffold P32120-2 281638 cow K293-sm 25350104 RGLALDGkLKHEDTN Arrestin_C molecular association, regulation AP-2 beta(INDUCES) 21118812 1 0 0 GPCR endocytosis induced -PI4K2A PI4K2A EC 2.7.1.67; Kinase, lipid; Motility/polarity/chemotaxis Q9BTU6 55361 10q24.2 human S51-p 468435 SGPSPPGsPGHDRER molecular association, regulation endocytosis, inhibited BRSK1(INDUCES); VACAMKL(INDUCES); TRIM3(INDUCES); CENTG1(INDUCES) 37314927 2 68 7 -TOP2B TOP2B iso2 Cell development/differentiation; DNA-binding; EC 5.99.1.3; Motility/polarity/chemotaxis; Nucleolus; Topoisomerase Q02880-2 7155 3p24.2 human S1130-p 23154509 HDDSSSDsGTPSGPD DNA_topoisoIV protein degradation; molecular association, regulation; ubiquitination carcinogenesis, induced BTRC(INDUCES) 32015321 1 1 1 -Crtc3 TORC3 Transcription, coactivator/corepressor Q91X84 70461 7|7 D3 mouse S62-p 3203139 LTQYHGGsLPNVSQL TORC_N molecular association, regulation transcription, inhibited 14-3-3 beta(INDUCES) 23033494 1 38 2 inhibits nuclear localization -Brsk2 BRSK2 EC 2.7.11.1; EC 2.7.11.26; KINASE; Kinase, protein; Protein kinase, CAMK; Protein kinase, Ser/Thr (non-receptor) Q69Z98 75770 7|7 F5 mouse T460-p 4734909 PKESPAGtPNPTPPS protein stabilization; enzymatic activity, inhibited; phosphorylation 23790753 1 2 2 inhibits axon branching (activated in BRSK2 18A mutant) -UNG UNG EC 3.2.2.27; Hydrolase P13051 7374 12q24.11 human Y8-p 460068 MIGQKTLySFFSPSP molecular association, regulation PCNA(DISRUPTS) 28746850 0 6 121 -SMURF1 SMURF1 EC 6.3.2.-; EC 6.3.2.19; Ligase; UBIQUITIN LIGASE; Ubiquitin conjugating system; Ubiquitin ligase Q9HCE7 57154 7q22.1 human K381-ub 964546162 YERDLVQkLKVLRHE protein degradation 21572392 1 1 0 -ERG ERG DNA-binding; Oncoprotein; Transcription factor P11308 2078 21q22.2 human K89-ac 56394102 PDECSVAkGGKMVGS molecular association, regulation carcinogenesis, induced; transcription, induced BRD4(INDUCES) 27223260 3 1 0 -OTUB1 OTUB1 DEUBIQUITINASE; EC 3.4.19.12; Protease; Ubiquitin conjugating system; Ubiquitin-specific protease Q96FW1 55611 11q13.1 human S18-p 3072783 QEPLGSDsEGVNCLA molecular association, regulation YpkA(INDUCES) 20553488 2 5 0 regulates bacterial uptake -H3C1 H3 DNA-binding P68431 8350 6p22.2 human K18-ac 465520 TGGKAPRkQLATKAA Histone molecular association, regulation; acetylation; methylation cell cycle regulation; carcinogenesis, induced; apoptosis, induced; transcription, induced; transcription, altered; DNA repair, induced; chromatin organization, altered; transcription, inhibited RCOR1(INDUCES); TIF1G(INDUCES) DNA(DISRUPTS) 12498683; 17560255; 18985155; 19196836; 19883641; 20720004; 21726812; 28953875; 31071955; 35222362; 35322029; 36060800 57 27 381 -RBBP8 CtIP EC 3.1.-.-; Transcription, coactivator/corepressor Q99708 5932 18q11.2 human S347-p 30992801 LDLNTSLsPSLLQPG enzymatic activity, induced 24837676 1 8 0 -Usp8 USP8 DEUBIQUITINASE; EC 3.4.19.12; Protease; Ubiquitin conjugating system; Ubiquitin-specific protease Q80U87 84092 2|2 F1 mouse T907-p 475072 TCRRRSRtFEAFMYL UCH enzymatic activity, induced cell growth, altered 17210635 1 0 0 increases de-ubiquitation activity towards E3-ligase Nrdp1 and the ErbB3 receptor -HIPK2 HIPK2 EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, CMGC; Protein kinase, Ser/Thr (non-receptor) Q9H2X6 28996 7q34 human S364-p 4783726 VCSTYLQsRYYRAPE Pkinase molecular association, regulation; intracellular localization; phosphorylation cell cycle regulation; cell growth, inhibited; transcription, inhibited SIAH2(INDUCES); PIN1(INDUCES) 23000554 1 10 325 -ZFYVE28 ZFYVE28 Cytoskeletal; Lipid-binding Q9HCC9 57732 4p16.3 human K87-ub 7250588 APRDFCVkFPEEIRH ubiquitination 19460345 1 10 124 -PIK3R1 PIK3R1 KINASE; Kinase, lipid; Motility/polarity/chemotaxis P27986 5295 5q13.1 human Y528-p 457097 IQRIMHNyDKLKSRI PI3K_P85_iSH2 molecular association, regulation; enzymatic activity, induced cell motility, altered SHP-2(INDUCES); IRS1(INDUCES) 16306077 1 3 6 -TNNI3 TNNI3 Actin-binding; Motility/polarity/chemotaxis; Motor P19429 7137 19q13.42 human S150-p 451822 TLRRVRIsADAMMQA Troponin activity, induced; molecular association, regulation cytoskeletal reorganization; signaling pathway regulation ACTB(DISRUPTS) 22456184; 22493448; 28018230 9 4 0 increases myofilament Ca(2+)-sensitive force development and blunts PKA-dependent desensitization -Prkcd PKCD EC 2.7.11.13; KINASE; Kinase, protein; Nuclear receptor co-regulator; Protein kinase, AGC; Protein kinase, Ser/Thr (non-receptor); Protein kinase, tyrosine (non-receptor); Tumor suppressor P09215 170538 16p16 rat T505-p 447511 FGENRAStFCGTPDY Pkinase enzymatic activity, induced 16361709; 18550549 51 21 108 -TP73 p73 DNA-binding; Transcription factor; Tumor suppressor O15350 7161 1p36.32 human K627-sm 2293700 KARKQPIkEEFTEAE protein degradation; intracellular localization cell cycle regulation; transcription, inhibited 10961991; 15572666 2 1 0 -CAD CAD Amino Acid Metabolism - alanine, aspartate and glutamate; EC 2.1.3.2; EC 3.5.2.3; EC 6.3.5.5; Hydrolase; KINASE; Ligase; Nucleotide Metabolism - pyrimidine; Transferase P27708 790 2p23.3 human S1406-p 451249 GAGGRRLsSFVTKGY MGS phosphorylation 17206380 4 35 5 inhibits phosphorylation of T456 -XRCC4 XRCC4 DNA repair, damage Q13426 7518 5q14.2 human S320-p 475981 HISAENMsLETLRNS XRCC4 DNA repair, induced 33503430 3 12 0 -Des desmin Cytoskeletal; Motility/polarity/chemotaxis P31001 13346 1 C4|1 38.85 cM mouse S7-p 466342 _MSQAYSsSQRVSSY transcription, altered; cell growth, altered 17381546 3 0 0 important for cardiomyogenesis -TP53 p53 Activator; DNA-binding; Motility/polarity/chemotaxis; Nuclear receptor co-regulator; Transcription factor; Tumor suppressor P04637 7157 17p13.1 human K321-ub 11263011 SSPQPKKkPLDGEYF P53_tetramer protein degradation; molecular association, regulation; intracellular localization KPNA4(DISRUPTS) 19927155 1 2 9 -ROS1 ROS EC 2.7.10.1; KINASE; Kinase, protein; Membrane protein, integral; Oncoprotein; Protein kinase, TK; Protein kinase, tyrosine (receptor) P08922 6098 6q22.1 human Y2274-p 454391 KNREGLNyMVLATEC molecular association, regulation SHP-1(INDUCES) 15456853 1 3 13 Mutation of Y2274 abolished ligand-dependent association of ROS with SHP-1. -COPS5 COPS5 Adaptor/scaffold; DEUBIQUITINASE; EC 3.4.-.-; Nuclear receptor co-regulator; Protease; Transcription, coactivator/corepressor; Translation Q92905 10987 8q13.1 human T205-p 1827354804 EGPSEYQtIPLNKIE enzymatic activity, inhibited signaling pathway regulation 31950832 1 1 0 NFkB signaling pathway -FOXO4 FOXO4 DNA-binding; Oncoprotein; Transcription factor P98177 4303 Xq13.1 human T451-p 448518 PIPKALGtPVLTPPT intracellular localization cell cycle regulation; transcription, induced 11689711; 15538382 3 3 0 -MAPT Tau iso8 ACETYLTRANSFERASE; Acetyltransferase; Cytoskeletal P10636-8 4137 17q21.31 human K174-ac 55529800 NATRIPAkTPPAPKT molecular association, regulation; protein stabilization Tau(INDUCES) 26390242; 35269542 5 1 0 hydrogen bonding interactions stabilize the acetylated Tau dimer, dimer stabilization and subsequent aggregation; promotes neurodegeneration and behavioral deficits -FOSB FosB DNA-binding; Transcription factor P53539 2354 19q13.32 human S27-p 465535 SAESQYLsSVDSFGS activity, induced; protein stabilization transcription, induced 16687504; 17241283 4 1 0 -Kcnd2 Kv4.2 Channel, potassium; Membrane protein, integral; Membrane protein, multi-pass Q63881 rat S537-p 4668100 CSRRHKKsFRIPNAN DUF3399 intracellular localization; phosphorylation 18795890 1 0 1 increases phosphorylation at T602 and T607 by ERK -POLI POLI DNA repair, damage; EC 2.7.7.7; Transferase Q9UNA4 11201 18q21.2 human K78-ub 50771305 SNPELKDkPLGVQQK IMS protein degradation 26370087 1 3 0 -NFKBIA IkB-alpha DNA-binding; Inhibitor P25963 4792 14q13.2 human K47-ub 4860400 EEYEQMVkELQEIRL protein degradation transcription, induced 9990853 2 1 0 -Exoc8 EXOC8 Vesicle O54924 245709 19q12 rat S276-p 182950103 EETKRALsDKRRREQ molecular association, regulation exocytosis, inhibited Sec5(DISRUPTS); EXOC8(DISRUPTS) 28325821 1 1 0 -GLUD1 GLUD1 Amino Acid Metabolism - alanine, aspartate and glutamate; Amino Acid Metabolism - arginine and proline; EC 1.4.1.3; Energy Metabolism - nitrogen; Mitochondrial; Other Amino Acids Metabolism - D-Glutamine and D-glutamate; Oxidoreductase P00367 2746 10q23.2 human S384-p 25739562 DILIPAAsEKQLTKS ELFV_dehydrog activity, induced; molecular association, regulation; enzymatic activity, induced carcinogenesis, induced; transcription, induced; signaling pathway regulation IKKB(INDUCES); NFkB-p65(INDUCES) 31447391 1 5 1 induces NF-kB activity and signaling -Ikzf1 Ikaros C2H2-type zinc finger protein; DNA-binding; Transcription factor Q03267 22778 11 A1|11 7.02 cM mouse T393-p 451353 SNSCQDStDTESNAE activity, inhibited cell cycle regulation DNA(DISRUPTS) 15024069 1 0 5 -SLC39A7 SLC39A7 Membrane protein, integral; Membrane protein, multi-pass; Transporter; Transporter, SLC family Q92504 7922 6p21.32 human S275-p 457019 RSTKEKQsSEEEEKE Zip activity, induced; phosphorylation exocytosis, induced; signaling pathway regulation 28205653; 31483418 2 19 9 maximal activation, SLC39A7 and Akt activation, zinc release and downstream effectors GSK3B, and p70 S6, phosphorylation of multiple kinases -NR3C1 GR DNA-binding; Mitochondrial; Nuclear receptor; Transcription factor P04150 2908 5q31.3 human S226-p 451796 IDENCLLsPLAGEDD GCR molecular association, regulation; intracellular localization; activity, inhibited transcription, induced; transcription, inhibited GRIP1(INDUCES) 12351702; 17440046; 20047289; 27013170; 28582465; 31974640 39 9 1 -GPM6A GPM6A Cell surface; Channel, calcium; Membrane protein, integral; Membrane protein, multi-pass P51674 2823 4q34.2 human Y251-p 7783489 DACRMQKyEDIKSKE cytoskeletal reorganization 25242528 1 1 1 neurite outgrowth -Mef2c MEF2C DNA-binding; Transcription factor Q8CFN5 17260 13 C3|13 43.68 cM mouse S110-p 4758829 ADDSVGHsPESEDKY HJURP_C molecular association, regulation PIN1(INDUCES) 20801874 1 5 2 Pin1 binding decreases MEF2C stability and its transcriptional activity -NR1H3 LXR-alpha DNA-binding; Motility/polarity/chemotaxis; Nuclear receptor Q13133 10062 11p11.2 human K434-sm 12004411 ALRLQDKkLPPLLSE molecular association, regulation transcription, inhibited DNA(INDUCES) 17218271 1 0 0 -DDB1 DDB1 DNA repair, damage Q16531 1642 11q12.2 human S645-p 7321234 LRTFRSLsTTNVFAC molecular association, regulation G-beta 2(DISRUPTS) 25982117 1 4 6 -Ctnnd1 CTNND1 Actin-binding; Adaptor/scaffold; Cell adhesion; G protein regulator, misc.; Motility/polarity/chemotaxis P30999 12388 2 D|2 49.45 cM mouse K625-ac 17391700 CFGAKKGkDEWFSRG cytoskeletal reorganization 16916647 0 1 0 -EGFR EGFR EC 2.7.10.1; KINASE; Kinase, protein; Membrane protein, integral; Oncoprotein; Protein kinase, TK; Protein kinase, tyrosine (receptor) P00533 1956 7p11.2 human Y1197-p 448060 STAENAEyLRVAPQS activity, induced; protein degradation; molecular association, regulation; receptor internalization, altered; intracellular localization; phosphorylation; enzymatic activity, induced carcinogenesis, induced; carcinogenesis, inhibited; cell motility, induced; cell growth, inhibited; transcription, induced; signaling pathway regulation; cell growth, induced; transcription, inhibited; cell growth, altered SH3KBP1(INDUCES); RASA1(INDUCES); GRB2(INDUCES); EGFR(INDUCES); SHC1(INDUCES); SHP-1(INDUCES); CBL(INDUCES) 10653583; 12177062; 1314835; 15708852; 16729043; 16943190; 2022651; 2022652; 21787862; 21918175; 23764002; 24430869; 26079946; 26290602; 26918609; 28102297; 3263271; 33947961; 33952697; 35184157; 35226996; 36012373; 37085908; 7506413; 8408058; 9733788 106 59 1028 -OTUB2 OTUB2 DEUBIQUITINASE; EC 3.4.19.12; Hydrolase; Ubiquitin-specific protease Q96DC9 78990 14q32.12 human K233-sm 1879841200 NILYAADkH______ protein stabilization; molecular association, regulation; intracellular localization carcinogenesis, induced TAZ(INDUCES); YAP1(INDUCES) 30472188 1 1 0 Enhances stem cell-like properties of breast cancer cells -CDT1 CDT1 DNA replication; DNA-binding; Motility/polarity/chemotaxis; Oncoprotein Q9H211 81620 16q24.3 human S143-p 1239966006 RVRALKAsAQDAGES cell cycle regulation; cytoskeletal reorganization 30154187 1 1 0 regulates kTM stability -RACGAP1 MgcRacGAP GAP; GAP, Rac/Rho Q9H0H5 29127 12q13.12 human S157-p 3211992 GSILSDIsFDKTDES molecular association, regulation; enzymatic activity, induced cell cycle regulation; cytoskeletal reorganization ECT2(INDUCES); PPP2CA(DISRUPTS) 19468302; 25486482; 27453045; 35477750 4 15 0 induces Rho GTPase activity -FOXP3 FOXP3 C2H2-type zinc finger protein; Cell cycle regulation; DNA-binding; Transcription factor Q9BZS1 50943 Xp11.23 human K250-ac 31914100 EQQLVLEkEKLSAMQ FOXP-CC protein stabilization 23644046 1 0 0 -Ksr1 KSR KINASE; Kinase, protein; Protein kinase, Ser/Thr (non-receptor); Protein kinase, TKL Q61097 16706 11 B5|11 46.74 cM mouse S443-p 449300 TTSSTPSsPAPFLTS intracellular localization; phosphorylation neural plasticity; signaling pathway regulation 21471251 2 0 0 ERK1/2 signaling -GNAQ G-alpha(q) G protein; G protein, heterotrimeric; G protein, heterotrimeric alpha G(q) P50148 2776 9q21.2 human S53-p 482964 GTGESGKsTFIKQMR G-alpha enzymatic activity, inhibited 17531806 1 1 0 inhibits G-alpha(q) signaling following infection of bacteria Yersinia pseudotuberculosis -MYB Myb DNA-binding; Oncoprotein; Transcription factor P10242 4602 6q23.3 human K480-ac 458942 ALAAQEIkYGPLKML Cmyb_C molecular association, regulation transcription, induced DNA(INDUCES) 10656693 1 1 0 -UFL1 UFL1 EC 6.3.2.-; Ligase; Tumor suppressor O94874 23376 6q16.1 human S462-p 15436603 DDDSDDEsQSSHTGK molecular association, regulation; enzymatic activity, induced DNA repair, induced NBS1(INDUCES) 30886146 1 4 9 activation of ATM signaling -Ikbke IKKE EC 2.7.11.10; Inhibitor; KINASE; Kinase, protein; Protein kinase, Other; Protein kinase, Ser/Thr (non-receptor) Q9R0T8 56489 1|1 E4 mouse S172-p 447631 DDDEKFVsVYGTEEY Pkinase enzymatic activity, induced 10421793 8 4 0 -GAB1 GAB1 Adaptor/scaffold; Motility/polarity/chemotaxis Q13480 2549 4q31.21 human Y259-p 448877 ASVDSSLyNLPRSYS molecular association, regulation CDK6(INDUCES) 19881549 2 29 488 promotes HGF-induced DNA synthesis -Plcg1 PLCG1 Carbohydrate Metabolism - inositol phosphate; EC 3.1.4.11; Motility/polarity/chemotaxis; Phospholipase Q62077 18803 2 H2|2 80.97 cM mouse Y783-p 447667 EGRNPGFyVEANPMP molecular association, regulation; protein conformation cell adhesion, altered PLCG1(INDUCES) 15657076; 15764700; 19917685; 26687682 92 42 558 -DHCR7 DHCR7 EC 1.3.1.21; Lipid Metabolism - steroid biosynthesis; Membrane protein, integral; Membrane protein, multi-pass; Oxidoreductase Q9UBM7 1717 11q13.4 human S14-p 4269796 PNIPKAKsLDGVTND enzymatic activity, induced 27520299 1 36 4 -PDCD6 PDCD6 O75340 10016 5p15.33 human K90-me 1881937801 SEFTGVWkYITDWQN protein stabilization carcinogenesis, induced; cell growth, induced; apoptosis, inhibited 35396512 1 1 0 K90R inhibits tumor growth and apoptosis, promotes cervical cancer growth under glucose deprivation mediated by AMPK activation -IRF5 IRF5 DNA-binding; Transcription factor Q13568 3663 7q32.1 human S158-p 27101102 QRMLPSLsLTEDVKW intracellular localization apoptosis, induced 22412986 1 1 0 nuclear localization- S158 requires an activator, while S435 and S446 do not. -Mpz myelin P0 Adaptor/scaffold; Membrane protein, integral P06907 24564 13q24 rat S228-p 458932 AMLDHSRsTKAASEK Myelin-PO_C cell adhesion, altered 17502419 2 1 0 -CCP110 CP110 Cell cycle regulation O43303 9738 16p12.3 human S372-p 9318022 PSPEPSMsPKMHRRR intracellular localization cell cycle regulation 12361598 1 17 3 -DCLRE1C Artemis DNA repair, damage; Deoxyribonuclease; EC 3.1.-.- Q96SD1 64421 10p13 human S648-p 38410203 TNADSQSsSDFEVPS molecular association, regulation; intracellular localization DNA repair, induced PAXIP1(INDUCES) 25512557 1 1 0 Artemis prevents end resection and promotes non-homologous end joining -ZFP64 ZFP64 C2H2-type zinc finger protein; DNA-binding; Transcription regulation Q9NTW7 55734 20q13.2 human S226-p 7322830 NKHLRIHsDERPFKC zf-H2C2_5 ubiquitination; intracellular localization carcinogenesis, induced; cell motility, induced; cell growth, induced; apoptosis, inhibited; transcription, induced 35219791 1 8 0 -SLC9A1 NHE1 Membrane protein, integral; Membrane protein, multi-pass; Motility/polarity/chemotaxis; Transporter; Transporter, SLC family P19634 6548 1p36.11 human S770-p 475073 MMRSKETsSPGTDDV activity, induced; protein stabilization; protein conformation 17209041; 23602949 6 2 0 phosphomimetic mutant was strongly stabilized and resulted in a more compact region which affects NHE1 activity. -Epor EPOR Membrane protein, integral; Receptor, cytokine P14753 13857 9 A3|9 7.93 cM mouse Y455-p 455532 PPHLKYLyLVVSDSG molecular association, regulation; receptor internalization, altered PIK3R2(INDUCES); PIK3R1(INDUCES) 19336760 8 0 0 required for optimal PIK3R1/2 binding -ETV5 ERM DNA-binding; Transcription factor P41161 2119 3q27.2 human S367-p 451201 PPYQRRGsLQLWQFL protein conformation transcription, induced 11682477 2 0 0 -TP53 p53 Activator; DNA-binding; Motility/polarity/chemotaxis; Nuclear receptor co-regulator; Transcription factor; Tumor suppressor P04637 7157 17p13.1 human K382-m2 4219800 QSTSRHKkLMFKTEG protein stabilization; molecular association, regulation; protein conformation p300(DISRUPTS); 53BP1(INDUCES) 18840612; 25651062; 33961797 3 1 0 -Gabrb3 GABRB3 Channel, chloride; Channel, ligand-gated; Membrane protein, integral; Membrane protein, multi-pass; Transporter; Transporter, ion channel P63080 14402 7 B5|7 33.53 cM mouse S433-p 450246 THLRRRSsQLKIKIP Neur_chan_memb molecular association, regulation; receptor desensitization, altered cytoskeletal reorganization AP-2 alpha(DISRUPTS) 14684872; 18184780; 26627235 13 0 3 increased dendritic spine density, alterations in GABRB3 expression, decreased social interaction and repetitive-like behavior in S408/9A mice -Tsc2 TSC2 Cell cycle regulation; GAP; GAP, misc.; Nuclear receptor co-regulator; Tumor suppressor Q61037 22084 17 A3.3|17 12.41 cM mouse S664-p 455575 KKASGPLsPPTGPPS Tuberin phosphorylation carcinogenesis, induced; signaling pathway regulation 35797217 9 9 1 induces 4E-BP1 and S6 phosphorylation thus regulating TORC1signaling, -STXBP5L STXBP5L Q9Y2K9 9515 3q13.33 human S771-p 15723219 CSSGKRLsSADVSKV protein degradation 25002582 1 2 0 ; in a multiple residue S->D mutant -PTPN11 SHP-2 EC 3.1.3.48; Motility/polarity/chemotaxis; PHOSPHATASE; Protein phosphatase, tyrosine (non-receptor) Q06124 5781 12q24.13 human Y580-p 448493 REDSARVyENVGLMQ molecular association, regulation; phosphorylation; enzymatic activity, induced carcinogenesis, induced; cell growth, induced; apoptosis, inhibited; cell motility, altered GRB2(INDUCES); SHP-2(INDUCES); Fyn(INDUCES) 11684012; 12531430; 20855525; 34657149 18 60 1189 -SIRT2 SIRT2 iso2 DEACETYLASE; Deacetylase; EC 3.5.1.- Q8IXJ6-2 22933 19q13.2 human S331-p 482809 PNPSTSAsPKKSPPP activity, inhibited cell cycle regulation 26303530 7 31 0 -Cnn3 calponin 3 Cytoskeletal; Motility/polarity/chemotaxis Q9DAW9 71994 3|3 G1 mouse S296-p 4776198 GTNGSEIsDSDYQAE molecular association, regulation cell differentiation, induced; cytoskeletal reorganization ACTA1(INDUCES) 23276748 2 4 9 -Socs3 SOCS3 Inhibitor O35718 12702 11|11 E2 mouse Y204-p 450446 VNGHLDSyEKVTQLP cell cycle regulation 31255914 5 2 12 -IRF3 IRF3 DNA-binding; Transcription factor Q14653 3661 19q13.33 human K77-ub 598897600 KPDLPTWkRNFRSAL IRF protein degradation; molecular association, regulation; ubiquitination autophagy, induced CALCOCO2(INDUCES) 29358709; 37330913 2 1 0 GPR108 and Smurf1 mediated degradation requires NDP52; NDP52-dependent autophagic degradation of phosphorylated IRF3; GPR108 interacts with Smurf1, followed by the recruitment of IRF3 during viral infection -Kcnj8 KCNJ8 Channel, potassium; Membrane protein, integral; Membrane protein, multi-pass Q63664 25472 4q44 rat S379-p 1458601 SELSHQNsLRKRNSM activity, inhibited 18048350 1 1 0 -Npr2 ANPB EC 4.6.1.2; Guanylyl cyclase; KINASE; Kinase, protein; Lyase; Membrane protein, integral; Nucleotide Metabolism - purine; Protein kinase, RGC; Protein kinase, dual-specificity (receptor); Receptor, misc. P16067 116564 5q22 rat T529-p 17557700 SSYGSLMtAHGKYQI PK_Tyr_Ser-Thr enzymatic activity, induced 20977274 1 1 0 -TRIM21 TRIM21 EC 6.3.2.-; Ligase; UBIQUITIN LIGASE; Ubiquitin conjugating system; Ubiquitin ligase P19474 6737 11p15.4 human K351-ac 1883534900 WEVDVTGkEAWDLGV enzymatic activity, induced 35770730 1 1 0 SIRT5 inhibits TRIM21 activity by deacetylation -SOX9 SOX9 DNA-binding; Transcription factor P48434 374148 chicken S181-p 456981 YQPRRRKsVKNGQSE sumoylation signaling pathway regulation 23382206 12 2 0 induce NCC delamination -CACNA1C CACNA1C Channel, calcium; Membrane protein, integral; Membrane protein, multi-pass BAA34185.2 guinea pig S1626-p 10349704 KKIWKRTsMKLLDQV Ca_chan_IQ activity, induced; molecular association, regulation; protein conformation Calmodulin(DISRUPTS) 30042022 3 0 0 -CLIP1 Restin iso3 Cytoskeletal P30622-2 6249 12q24.31 human S1318-p 3189736 DDLNNYDsDDQEKQS protein stabilization; intracellular localization cell cycle regulation; carcinogenesis, induced; apoptosis, inhibited; transcription, altered 23661607 3 17 0 induce AR stabilization and nuclear translocation/accumulation -Kcnq2 Kv7.2 Channel, potassium; Membrane protein, integral; Membrane protein, multi-pass O88943 170848 3q43 rat S534-p 11082900 CVMRFLVsKRKFKES KCNQ_channel activity, induced 12754513 1 0 0 Mutants showed reduced currents induced by acetylcholine. -PGM1 PGM1 Carbohydrate Metabolism - amino sugar and nucleotide sugar; Carbohydrate Metabolism - galactose; Carbohydrate Metabolism - glycolysis and gluconeogenesis; Carbohydrate Metabolism - pentose phosphate pathway; Carbohydrate Metabolism - starch and sucrose; EC 5.4.2.2; Isomerase P36871 5236 1p31.3 human T467-p 454029 SANDKVYtVEKADNF enzymatic activity, induced 15378030 1 0 0 -Runx1 AML1 DNA-binding; Oncoprotein; Transcription factor Q03347 12394 16 C4|16 53.7 cM mouse Y386-p 51211404 YGASAGSyQFSMVGG RunxI activity, induced; protein stabilization transcription, induced HDAC1(DISRUPTS) DNA(INDUCES) 26598521 1 0 0 -RET Ret EC 2.7.10.1; KINASE; Kinase, protein; Membrane protein, integral; Oncoprotein; Protein kinase, TK; Protein kinase, tyrosine (receptor) P07949 5979 10q11.21 human Y826-p 449893 SRKVGPGyLGSGGSR PK_Tyr_Ser-Thr enzymatic activity, induced 28009299 3 2 15 -Tp53 p53 Activator; DNA-binding; Motility/polarity/chemotaxis; Nuclear receptor co-regulator; Transcription factor; Tumor suppressor P02340 22059 11 B3|11 42.83 cM mouse S18-p 447490 ISLELPLsQETFSGL P53_TAD activity, induced; molecular association, regulation; protein stabilization; intracellular localization; protein conformation; phosphorylation cell cycle regulation; carcinogenesis, induced; apoptosis, altered; carcinogenesis, inhibited; cell growth, inhibited; apoptosis, induced; transcription, induced; transcription, altered; DNA repair, induced; apoptosis, inhibited; transcription, inhibited; cell growth, altered 14-3-3 beta(INDUCES); p53(INDUCES); STRAP(INDUCES); NME1(INDUCES); p21Cip1(INDUCES) 10747924; 10781582; 11470783; 12065413; 12186934; 12356735; 12524542; 12857758; 12907610; 12909629; 14729946; 15226436; 15866171; 15975986; 16314418; 16757976; 18089799; 18519674; 18606816; 18769132; 20145032; 20876800; 21887248; 22532570; 25101980; 27568562; 34930892; 35210557; 36516759 480 12 0 -NDUFA10 NDUFA10 EC 1.6.5.3; EC 1.6.99.3; Energy Metabolism - oxidative phosphorylation; Mitochondrial; Oxidoreductase O95299 4705 2q37.3 human S250-p 32001601 KTFLPEMsEKCEVLQ dNK activity, induced 28137779 2 1 0 electron transfer from complex I to ubiquinone -HSPB1 HSP27 Chaperone; Heat shock protein; Motility/polarity/chemotaxis; SUMO LIGASE; SUMO ligase P04792 3315 7q11.23 human S83-p 452224 ALSRQLSsGVSEIRH molecular association, regulation cell differentiation, induced Tau(INDUCES) 31974309; 34581912 3 21 23 -Kcnj1 ROMK Channel, potassium; Membrane protein, integral; Membrane protein, multi-pass O88335 56379 9|9 A4 mouse S25-p 449605 RQRARLVsKDGRCNI IRK activity, induced; intracellular localization 12684516 9 0 0 -Junb JunB Motility/polarity/chemotaxis; Oncoprotein; Transcription factor P09450 16477 8 C3|8 41.41 cM mouse K267-sm 3144822 MEDQERIkVERKRLR bZIP_1 intracellular localization transcription, induced 18424718 1 0 0 -APBB1 Fe65 Adaptor/scaffold; Apoptosis; Transcription regulation O00213 322 11p15.4 human S610-p 2035401 ECRVRFLsFLAVGRD PID molecular association, regulation; intracellular localization; protein conformation APP(DISRUPTS) 26188042 2 0 0 -SQSTM1 SQSTM1 Autophagy; Nuclear receptor co-regulator; Ubiquitin conjugating system Q13501 8878 5q35.3 human K420-ac 1879848302 LTRLLQTkNYDIGAA molecular association, regulation ubiquitin(INDUCES); SQSTM1(DISRUPTS) 31857589 1 1 0 enhances p62 body formation, clearance of poly-Ub proteins -Esrrg ERR3 DNA-binding; Nuclear receptor; Transcription factor P62509 26381 1|1 H5-H6 mouse K360-sm 1725303 VKKYKSMkLEKEEFV Hormone_recep transcription, inhibited 18063693 1 0 0 -GPRC5A RAIG1 GPCR, family 3; Membrane protein, integral; Membrane protein, multi-pass; Receptor, GPCR Q8NFJ5 9052 12p13.1 human Y320-p 455045 GDTLYAPySTHFQLQ cell growth, induced 25311788 1 13 174 Tyrosine phosphorylation inhibits the suppressive effect of RAIG1 on cell invasion and anchorage-independent growth. -ZDHHC13 ZDHHC13 EC 2.3.1.225; Membrane protein, integral; Membrane protein, multi-pass; Transferase Q8IUH4 54503 11p15.1 human S8-p 41455513 MEGPGLGsQCRNHSH molecular association, regulation MC1R(INDUCES) 28869973 1 1 0 -PPP2R5D PPP2R5D Motility/polarity/chemotaxis; PHOSPHATASE; Protein phosphatase, regulatory subunit Q14738 5528 6p21.1 human S573-p 457390 KVLLRRKsELPQDVY enzymatic activity, inhibited 30115685 7 53 347 PP1 inactivates -JUN Jun Oncoprotein; Transcription factor P05412 3725 1p32.1 human K226-sm 2793916 HPRLQALkEEPQTVP Jun intracellular localization transcription, induced; transcription, inhibited 16055710; 19106612 5 2 0 sumoylation of PML is necessary for coactivating transcription with c-Jun; intranuclear distribution -VGLL4 VGLL4 iso4 Transcription, coactivator/corepressor Q14135-4 9686 3p25.3-p25.2 human S58-p 478547 RTGPPPIsPSKRKFS VGLL4 cell cycle regulation; cell growth, induced 28739871 1 27 40 Mitotic phosphorylation -CNOT7 CNOT7 EC 3.1.13.4; Transcription, coactivator/corepressor Q9UIV1 29883 8p22 human K200-ac 59117701 YDVKYLMkSCKNLKG CAF1 molecular association, regulation cell differentiation, inhibited; RNA stability, inhibited RNA(INDUCES) 27635759 1 1 0 -MYH10 MYH10 Motility/polarity/chemotaxis; Motor P35580 4628 17p13.1 human S1956-p 465600 EGASLELsDDDTESK molecular association, regulation; intracellular localization cytoskeletal reorganization MYH10(INDUCES); ACTA1(INDUCES) 25869664; 30087119; 30655296 4 74 5 -Abl2 Arg EC 2.7.10.2; KINASE; Kinase, protein; Oncoprotein; Protein kinase, TK; Protein kinase, tyrosine (non-receptor) Q4JIM5 11352 1 G3|1 67.71 cM mouse Y439-p 447923 RLMTGDTyTAHAGAK PK_Tyr_Ser-Thr enzymatic activity, induced 12748290 4 39 1640 -CALD1 Caldesmon Actin-binding NP_776683 281660 cow S531-p 448466 QSVDKVTsPTKV___ molecular association, regulation; intracellular localization cytoskeletal reorganization MYH1(DISRUPTS) 12788788; 15521070 19 19 0 -Aatk Lmr1 EC 2.7.11.1; KINASE; Kinase, protein; Membrane protein, integral; Protein kinase, Ser/Thr (non-receptor); Protein kinase, TK; Protein kinase, tyrosine (receptor) Q80YE4 11302 11|11 E2 mouse S528-p 456513 VPVLSAHsPSVGSEY apoptosis, induced 16100393 1 0 0 -Atp2a2 SERCA2 Cell adhesion; EC 3.6.3.8; Endoplasmic reticulum; Hydrolase; Membrane protein, integral; Membrane protein, multi-pass; Transporter; Transporter, ion channel P11507 29693 12q16 rat S38-p 448740 KLKERWGsNELPAEE Cation_ATPase_N activity, induced 7929371 1 6 0 Phosphorylation by CaM kinase increased the Vmax for Ca++ transport. -UBE3A UBE3A iso2 EC 6.3.2.-; EC 6.3.2.19; Ligase; Nuclear receptor co-regulator; Transcription, coactivator/corepressor; UBIQUITIN LIGASE; Ubiquitin conjugating system; Ubiquitin ligase Q05086-2 7337 15q11.2 human T485-p 48891100 MYSERRItVLYSLVQ protein stabilization; molecular association, regulation; intracellular localization; enzymatic activity, inhibited cytoskeletal reorganization; transcription, altered RAD23A(DISRUPTS); 14-3-3 gamma(INDUCES) 26255772; 28559284; 28835500 3 1 0 -DIXDC1 DIXDC1 iso2 Cell adhesion; Cell development/differentiation Q155Q3-2 85458 11q23.1 human S381-p 23099075 SKLPHSQsSPTVSST cytoskeletal reorganization 27829159 1 2 2 regulates microtubule network, dendritic spine growth -MAPK7 ERK5 EC 2.7.11.24; KINASE; Kinase, protein; Protein kinase, CMGC; Protein kinase, Ser/Thr (non-receptor) Q13164 5598 17p11.2 human S731-p 455519 DPLPPVFsGTPKGSG intracellular localization; enzymatic activity, inhibited; phosphorylation; enzymatic activity, induced cell growth, induced; apoptosis, inhibited; transcription, induced; transcription, altered 20667468; 30132833; 31201162 5 11 0 MYCN protein; in DIPG cells -Tsc2 TSC2 Cell cycle regulation; GAP; GAP, misc.; Nuclear receptor co-regulator; Tumor suppressor P49816 24855 10q12 rat S1377-p 469993 ARPTVDLsFQPSQPL activity, inhibited; phosphorylation translation, altered; apoptosis, inhibited 16959574 1 1 8 inhibits mTOR signaling. required for Wnt-3a to stimulation phosphorylation of S6K and 4EBP1 and increase protein levels of cyclin D1 and VEGF (cyclin D1 through translation not transcription). -ECT2 ECT2 GEF; GEF, Rac/Rho; Motility/polarity/chemotaxis Q9H8V3 1894 3q26.31 human T373-p 456870 VSMLSLNtPNSNRKR activity, induced; protein conformation 16170345 3 14 4 -PTEN PTEN Carbohydrate Metabolism - inositol phosphate; EC 3.1.3.16; EC 3.1.3.48; EC 3.1.3.67; Motility/polarity/chemotaxis; Nuclear receptor co-regulator; PHOSPHATASE; Phosphatase, lipid; Tumor suppressor P60484 5728 10q23.31 human K13-ub 27490407 KEIVSRNkRRYQEDG intracellular localization apoptosis, induced; exocytosis, induced 23012657; 23637190 6 0 0 inhibition of PTEN nuclear translocation protects against ischemic-neuronal injuries; Ndfip regulates of the exosomal export of PTEN, -TPM3 TPM3 Actin-binding; Contractile; Cytoskeletal; Motility/polarity/chemotaxis; Motor; Oncoprotein P06753 7170 1q21.3 human S284-p 484088 HALNDMTsI______ Tropomyosin cytoskeletal reorganization 32977471 1 12 75 -PCNT PCNT Cell cycle regulation O95613 5116 21q22.3 human S1241-p 25617501 ISSHMREsFLMSPES cytoskeletal reorganization 22184200; 24466316 2 0 0 important for spindle formation and centrosomal microtubule nucleation and the recruitment of the PCM proteins for centrosome maturation in mitosis; centrosome maturation and bipolar spindle formation during mitosis -TRIM28 TIF1B EC 6.3.2.-; KINASE; Kinase, protein; Ligase; Nuclear receptor co-regulator; Protein kinase, atypical; SUMO LIGASE; SUMO ligase; Transcription, coactivator/corepressor; UBIQUITIN LIGASE; Ubiquitin conjugating system; Ubiquitin ligase Q13263 10155 19q13.43 human K779-sm 2798309 FNKLTEDkADVQSII molecular association, regulation; acetylation; methylation cell growth, induced; transcription, inhibited CHD-3(INDUCES) 17079232; 17942393; 21642969; 31391303 6 8 0 loss of TF1B sumoylation induces dsRNA-activated IFN-mediated defenses that rely on RIG-I, MAVS, TBK1, and JAK1 transcription, SUMOylated TIF1B Is required to support efficient virus replication -MED28 MED28 Transcription factor Q9H204 80306 4p15.32 human Y64-p 466940 ASLVSQDyVNGTDQE Med28 molecular association, regulation GRB2(INDUCES) 16899217 1 0 0 -Cry2 CRY2 DNA-binding; Lyase Q9R194 12953 2|2 E1 mouse S553-p 456804 TGPRALSsGPASPKR protein degradation 15980066; 20123978 2 1 0 required for the circadian time-keeping mechanism -Fto FTO DEMETHYLASE; Demethylase; EC 1.14.11.- Q8BGW1 26383 8 C4-C5|8 44.34 cM mouse S249-p 1115398000 YSYSCEGsEDESEDE FTO_NTD protein degradation; ubiquitination 29777057 1 1 0 -PRKCH PKCH EC 2.7.11.13; KINASE; Kinase, protein; Protein kinase, AGC; Protein kinase, Ser/Thr (non-receptor) P24723 5583 14q23.1 human T656-p 3914109 IKEEPVLtPIDEGHL Pkinase_C protein stabilization; enzymatic activity, induced DNA repair, induced; cell motility, induced; cell growth, induced; apoptosis, inhibited 34593629 2 10 8 -Irs1 IRS1 Adaptor/scaffold; Motility/polarity/chemotaxis P35569 16367 1 C5|1 42.0 cM mouse Y891-p 447556 EPKSPGEyVNIEFGS signaling pathway regulation 20332342 13 2 0 Rictor/mTORC2 signaling in energy metabolism in fat cells -Myo3b MYO3B Actin-binding; EC 2.7.11.1; KINASE; Kinase, protein; Motor; Protein kinase, STE; Protein kinase, Ser/Thr (non-receptor) Q1EG27 329421 2|2 C2 mouse T1246-p 36841909 YYNQLNGtLEYQGSQ enzymatic activity, induced 21895655 1 1 0 -IRS1 IRS1 Adaptor/scaffold; Motility/polarity/chemotaxis P35568 3667 2q36.3 human S794-p 447557 QHLRLSTsSGRLLYA molecular association, regulation; phosphorylation apoptosis, induced; signaling pathway regulation; cell growth, altered PIK3C2A(DISRUPTS); PIK3R1(DISRUPTS) 17459875; 20363874 10 0 0 decreases IRS1-tyrosine phosphorylation, decreases protein synthesis, inhibits Akt/TSC2/p70S6K signaling pathway -FOXC2 FOXC2 Apoptosis; Cell development/differentiation; DNA-binding; Transcription factor Q99958 2303 16q24.1 human S367-p 28129600 DHPSGPTsPLSALNL molecular association, regulation cell motility, induced; transcription, induced; transcription, altered DNA(INDUCES) 23878394; 27292262 3 1 0 confer combined EMT and stem cell attributes in vitro, promotes metastasis, directly regulates ZEB1 expression; implicated in vascular remodeling in vivo -NOXA1 NOXA1 Activator Q86UR1 10811 9q34.3 human S461-p 990301 VPAGPRMsGAPGRLP molecular association, regulation; intracellular localization; enzymatic activity, inhibited 14-3-3 zeta(INDUCES) 17913709 2 0 0 regulates association with 14-3-3 and dissociation from Nox1, which in-turn inhibits Nox1 activity and production of ROS -EPN1 epsin 1 Motility/polarity/chemotaxis; Vesicle Q9Y6I3 29924 19q13.42 human S382-p 3178200 FSDPWGGsPAKPSTN molecular association, regulation AP2A1(DISRUPTS); REPS2(DISRUPTS) 10764745 1 0 0 Phosphorylation inhibits binding during mitosis. S357D mutation lost effect of insulin-dependent endocytosis.; Phosphorylation inhibits during mitosis -NUP62 NUP62 Adaptor/scaffold; Nucleoporin P37198 23636 19q13.33 human Y422-p 463925 KEQSGTIyLQHADEE Nsp1_C intracellular localization 25349423 1 0 5 -FUS hnRNP P2 DNA-binding; Nuclear receptor co-regulator; Oncoprotein; RNA splicing; RNA-binding; SUMO LIGASE P35637 2521 16p11.2 human S346-p 14160213 VSFDDPPsAKAAIDW RRM_1 molecular association, regulation hnRNP P2(DISRUPTS) 35753345 1 6 0 -SHC1 SHC1 Adaptor/scaffold; Apoptosis; Mitochondrial; Motility/polarity/chemotaxis P29353 6464 1q21.3 human Y427-p 448511 ELFDDPSyVNVQNLD molecular association, regulation apoptosis, altered; cell motility, altered; cell growth, altered GRB2(INDUCES); GRB2(NOT_REPORTED); PPP2CA(DISRUPTS) 11884620; 15688026; 7731718; 8084588; 8947042; 9083103 42 91 1971 -Hspb1 HSP27 Chaperone; Heat shock protein; Motility/polarity/chemotaxis; SUMO LIGASE; SUMO ligase P14602 15507 5 G2|5 75.51 cM mouse S86-p 448403 RALNRQLsSGVSEIR activity, induced; intracellular localization apoptosis, inhibited 15731106 78 104 289 -VAV1 VAV1 GEF; GEF, Rac/Rho; Motility/polarity/chemotaxis; Oncoprotein P15498 7409 19p13.3 human Y836-p 14652800 VGWFPANyVEEDYSE carcinogenesis, altered; cell growth, altered 20457609 2 1 0 -H2BC3 H2B DNA-binding P33778 3018 6p22.2 human S112-gl 22267603 ELAKHAVsEGTKAVT intracellular localization transcription, induced 35690146 2 1 0 Dot1L is recruited OGT to chromatin to enhance histone H2B S112 O-GlcNAc and increases H2B K120 ubiquitination -FANCD2 FANCD2 DNA repair, damage Q9BXW9 2177 3p25.3 human S178-p 482181 NIPRLIVsQLKWLDR FancD2 activity, induced; molecular association, regulation; ubiquitination; intracellular localization signaling pathway regulation DNA(INDUCES) 37392383 1 2 0 regulates the FA pathway -Musk MUSK EC 2.7.10.1; KINASE; Kinase, protein; Membrane protein, integral; Protein kinase, TK; Protein kinase, tyrosine (receptor) Q62838 rat Y750-p 3146801 FGLSRNIySADYYKA PK_Tyr_Ser-Thr phosphorylation; enzymatic activity, induced 10619845 1 3 0 promotes MuSK phosphorylation; promotes AChRb clustering and phosphorylation -JUN Jun Oncoprotein; Transcription factor P05412 3725 1p32.1 human T8-p 17737604 MTAKMETtFYDDALN Jun carcinogenesis, altered; cell growth, altered 21177766 1 0 0 -FLII FLI Actin-binding; Nuclear receptor co-regulator Q13045 2314 17p11.2 human S436-p 470489 RLRRRKDsAQDDQAK molecular association, regulation carcinogenesis, induced; autophagy, inhibited; transcription, induced KHDRBS1(INDUCES) 19293151; 29898994 3 28 255 may induce transcription of the estrogen receptor; formation of aggregates -SAT1 SAT ACETYLTRANSFERASE; Acetyltransferase; Amino Acid Metabolism - arginine and proline; EC 2.3.1.57 P21673 6303 Xp22.11 human K87-ub 486249 TYDPWIGkLLYLEDF Acetyltransf_1 protein degradation 11485561 1 0 0 -FOXA1 FOXA1 DNA-binding; Transcription factor P55317 3169 14q21.1 human Y464-p 60189901 PAYYQGVySRPVLNT transcription, induced 27883218 1 0 0 -PDGFRA PDGFRA EC 2.7.10.1; KINASE; Kinase, protein; Membrane protein, integral; Oncoprotein; Protein kinase, TK; Protein kinase, tyrosine (receptor) P16234 5156 4q12 human Y988-p 450905 RVDSDNAyIGVTYKN molecular association, regulation PLCG1(INDUCES) 7535778 3 6 19 -Psma6 PSMA6 EC 3.4.25.1; Protease; Proteasome complex Q9QUM9 26443 12|12 C1 mouse K104-ac 475743 EAANWKYkYGYEIPV Proteasome protein degradation 24037710 0 7 27 -Pdpk1 PDK1 EC 2.7.11.1; KINASE; Kinase, protein; Nuclear receptor co-regulator; Protein kinase, AGC; Protein kinase, Ser/Thr (non-receptor) Q9Z2A0 18607 17|17 A3.3 mouse K299-sm 1876391104 LIFQKIIkLEYHFPE Pkinase phosphorylation; enzymatic activity, induced cell growth, induced; signaling pathway regulation 35210408 1 0 0 induces autophosphorylation of itself and mTOR signaling -IRF1 IRF1 Transcription factor; Tumor suppressor P10914 3659 5q31.1 human K299-sm 2134717 QRVFTDLkNMDATWL protein stabilization; ubiquitination carcinogenesis, induced; apoptosis, inhibited; transcription, inhibited 17942705 1 0 0 inhibits ubiquitination -SARM1 SARM1 Q6SZW1 23098 17q11.2 human S548-p 4739912 AAREMLHsPLPCTGG enzymatic activity, induced 30333228 3 9 3 inhibits mitochondrial respiration -FXYD1 PLM Cell surface; Channel, misc.; Membrane protein, integral O00168 5348 19q13.12 human S83-p 451424 EEGTFRSsIRRLSTR activity, induced; molecular association, regulation; enzymatic activity, induced ATP1A1(DISRUPTS); PLM(INDUCES) 21220422; 21653224; 26429909 22 20 60 enhances PLM oligomerization and modulates its interaction with Na/K-ATPase (NKA); reverse PLM bindiing inhibition of Na,K-ATPase activity ; induces Na+K+ATPase activity -KARS1 KARS Aminoacyl-tRNA synthetase; EC 6.1.1.6; Ligase; Mitochondrial; Translation; Translation regulation Q15046 3735 16q23.1 human T52-p 25692907 EKQLSQAtAAATNHT molecular association, regulation; intracellular localization cell motility, induced EPRS(DISRUPTS) 22751010; 30188867 2 1 0 increase the membrane level of 67LR -GTF2I GTF2I DNA-binding; Transcription, coactivator/corepressor P78347 2969 7q11.23 human Y249-p 459606 ESEDPDYyQYNIQAG activity, induced; intracellular localization transcription, induced; transcription, altered 15664986; 16738337; 20568114; 9837922 5 1 1 -Cacna1b CACNA1B Channel, calcium; Membrane protein, integral; Membrane protein, multi-pass Q02294 257648 3p13 rat S1757-p 465548 FEMLKHMsPPLGLGK GPHH activity, induced 16704976; 19167461 2 0 0 -Gria1 GluR1 Channel, calcium; Channel, ligand-gated; Membrane protein, integral; Membrane protein, multi-pass P23818 14799 11 B1.3|11 34.51 cM mouse S836-p 467226 CYKSRSEsKRMKGFC intracellular localization 19004011 6 0 0 -Atp2a2 SERCA2 Cell adhesion; EC 3.6.3.8; Endoplasmic reticulum; Hydrolase; Membrane protein, integral; Membrane protein, multi-pass; Transporter; Transporter, ion channel O55143 11938 5 62.38 cM|5 F mouse K492-ac 1878093100 LEFSRDRkSMSVYCT enzymatic activity, inhibited 30786847 1 1 0 regulation of ATPase activity, binding of ATP to SERCA2a -RTCB RTCB EC 6.5.1.3 Q9Y3I0 51493 22q12.3 human Y316-p 1876333508 GMAAAGNyAWVNRSS RtcB RNA splicing, inhibited 35193953 1 1 0 -NFE2 NF-E2 Cytoskeletal; DNA-binding; Transcription factor Q16621 4778 12q13.13 human K368-ub 11489907 FLVPRGTkMEATD__ protein degradation; ubiquitination transcription, inhibited 19966288 1 0 0 -Mecp2 MECP2 Transcription, coactivator/corepressor Q9Z2D6 17257 X A7.3|X 37.63 cM mouse S424-p 3191614 PRGGSLEsDGCPKEP molecular association, regulation transcription, inhibited DNA(DISRUPTS) 21765426 1 6 0 -Dync1i2 DYNC1I2 Microtubule-binding; Motility/polarity/chemotaxis; Motor Q62871 116659 3q22 rat S89-p 3195347 VPPPMSPsSKSVSTP molecular association, regulation; intracellular localization endocytosis, induced; cell motility, induced PXN(DISRUPTS); FAK(DISRUPTS); dynactin 1(DISRUPTS) 22553211 1 7 1 regulates focal adhesion turnover and stability; interaction between paxillin and DYNC1I2 facilitates endocytosis -ULK1 ULK1 Autophagy; EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, Other; Protein kinase, Ser/Thr (non-receptor) O75385 8408 12q24.33 human K162-ac 27850502 NPNSIRVkIADFGFA Pkinase enzymatic activity, induced apoptosis, induced 22539723 2 1 0 serum deprivation induced autophagy -EIF4G1 eIF4G iso8 RNA-binding; Translation; Translation initiation Q04637-8 1981 3q27.1 human S1232-p 449798 EAALPPVsPLKAALS molecular association, regulation Mnk1(INDUCES); eIF3-alpha(DISRUPTS); EIF4B(DISRUPTS); EIF4A1(DISRUPTS) 23263986 6 88 59 controls formation of translation initiation complex -Fzd3 FZD3 GPCR, Fz/Smo family; Membrane protein, integral; Membrane protein, multi-pass; Receptor, GPCR Q61086 14365 14 D1|14 34.09 cM mouse S625-p 18507005 TDHSRHSsSHRLNEQ receptor internalization, inhibited; phosphorylation endocytosis, inhibited 21316586 1 0 0 enhances PCP signaling, regulating c-Jun phosphorylation, and affecting growth cone guidance -WASL N-WASP Adaptor/scaffold; Motility/polarity/chemotaxis O00401 8976 7q31.32 human Y256-p 450253 RETSKVIyDFIEKTG PBD activity, induced; molecular association, regulation; phosphorylation cell adhesion, induced; cytoskeletal reorganization N-WASP(INDUCES) 20146487; 20940394; 21097841; 34369620 9 65 1373 -ATF4 ATF-4 DNA-binding; Transcription factor P18848 468 22q13.1 human T114-p 40420007 TMPDDLLtTLDDTCD protein degradation transcription, inhibited 25795775 1 1 0 -GOT2 GOT2 Amino Acid Metabolism - alanine, aspartate and glutamate; Amino Acid Metabolism - arginine and proline; Amino Acid Metabolism - cysteine and methionine; Amino Acid Metabolism - phenylalanine; Amino Acid Metabolism - phenylalanine, tyrosine and tryptophan biosynthesis; Amino Acid Metabolism - tyrosine; EC 2.6.1.1; EC 2.6.1.7; Mitochondrial; Transferase P00505 2806 16q21 human K159-ac 466485 SRDVFLPkPTWGNHT Aminotran_1_2 molecular association, regulation; phosphorylation carcinogenesis, induced; cell growth, induced; apoptosis, inhibited MDH2(INDUCES) 25755250 1 8 32 induces H3 phosphorylation -SMCR8 SMCR8 Unknown function Q8TEV9 140775 17p11.2 human T796-p 55469600 ASPAGAGtLHALSRY autophagy, induced 27103069 1 0 0 -Dab1 DAB1 iso2 Adaptor/scaffold P97318-2 13131 4 C6|4 47.79 cM mouse S491-p 479422 TPAPRQSsPSKSSAS molecular association, regulation; intracellular localization; phosphorylation signaling pathway regulation SH3KBP1(DISRUPTS) 16529723; 18076569; 23506116 7 0 0 regulates trafficking of reelin receptors and hence Reelin signaling pathway -Rasgrf1 RASGRF1 GEF; GEF, Ras P28818 192213 8q31 rat S71-p 18710203 GLYLLEGsICKRMPS PH protein degradation 21382555 1 1 0 -MAVS MAVS Adaptor/scaffold; Membrane protein, integral Q7Z434 57506 20p13 human S338-gl 1872691001 KPPGAVPsNALTNPA phosphorylation 31461653 1 1 0 positively regulates phosphorylation of S442 (data from MAVS 7A mutant) -PTTG1 Securin Cell cycle regulation; Oncoprotein O95997 9232 5q33.3 human T60-p 1239966004 PPALPKAtRKALGTV Securin molecular association, regulation 30154144 1 0 0 nuclear localization -Gabrg2 GABRG2 iso2 Channel, chloride; Channel, ligand-gated; Membrane protein, integral; Membrane protein, multi-pass; Transporter; Transporter, ion channel P22723-2 14406 11 A5|11 24.8 cM mouse Y403-p 455817 LQERDEEyGYECLDG Neur_chan_memb receptor inactivation, induced; activity, induced; receptor internalization, inhibited neural plasticity 17442679; 23904608; 24068823 7 0 0 potentiated GABA currents; neurogenesis, reduces depressive like behaviors; knockout leads to increease in GABA mediated tonic current, in females only -RECQL4 RECQL4 EC 3.6.4.12; Helicase O94761 9401 8q24.3 human S251-p 25173044 EVSIRVGsPQPSSSG ubiquitination; intracellular localization DNA repair, induced DDB1(INDUCES); MRE11A(INDUCES) 29229926 1 15 0 enhances the helicase activity; DNA end resection and HR ; promotes its ubiquitination by DDB1-CUL4A E3 ubiquitin ligase; recruitment to DSBs -FBXO43 FBX43 Unknown function Q4G163 286151 8q22.2 human S76-p 12581000 STSSFQDsGYNELKS protein degradation; ubiquitination 15753281 1 0 0 -Asic1 ASIC1 Channel, cation; Membrane protein, integral; Membrane protein, multi-pass; Transporter; Transporter, ion channel P55926 79123 7q36 rat S477-p 449558 QKEAKRSsADKGVAL activity, inhibited apoptosis, altered 16301179 2 0 0 -DAXX DAXX Apoptosis; Nuclear receptor co-regulator; Nucleolus; Transcription, coactivator/corepressor Q9UER7 1616 6p21.32 human S737-p 467726 PEEIIVLsDSD____ sumoylation; molecular association, regulation apoptosis, altered; transcription, altered SUMO1(INDUCES); PML(INDUCES) 21474068 1 20 0 -Klc2 KLC2 Microtubule-binding; Motor O88448 16594 19 A|19 4.25 cM mouse S575-p 452949 SRMKRASsLNFLNKS molecular association, regulation 14-3-3 eta(INDUCES) 11969417 2 75 63 -ACLY ACLY Carbohydrate Metabolism - citrate (TCA) cycle; EC 2.3.3.8; Lyase; Transferase P53396 47 17q21.2 human K546-ub 12107257 QKFYWGHkEILIPVF CoA_binding protein degradation carcinogenesis, inhibited; cell growth, inhibited 27664236 1 6 1 -ARHGDIA RhoGDI alpha Apoptosis; Cell adhesion; Cell development/differentiation; G protein regulator, misc.; Motility/polarity/chemotaxis P52565 396 17q25.3 human S176-p 1876737500 MLARGSYsIKSRFTD Rho_GDI activity, induced; molecular association, regulation; enzymatic activity, induced carcinogenesis, induced; cell motility, induced; signaling pathway regulation 14-3-3 theta(INDUCES) 24820414 1 0 0 14-3-3 theta (aka 14-3-3tau) interaction with RhoGD1 alpha is necessary for the release and activation of RhoA, Rac1 and Cdc42 -Abcc9 ABCC9 Channel, potassium; Membrane protein, integral; Membrane protein, multi-pass; Transporter; Transporter, ABC family P70170 20928 6 G2|6 74.35 cM mouse S1387-p 483973 HTLRSRLsIILQDPI ABC_tran activity, induced; protein conformation 17596331; 18198173 2 0 0 Molecular modeling shows phosphorylated S1387 interacts with Y506 and R1462 leading to channel activation. -Ikbkg IKKG Adaptor/scaffold; Protein kinase, regulatory subunit O88522 16151 X|X A7.3 mouse K302-sm 2255103 KAQADIYkADFQAER CC2-LZ phosphorylation signaling pathway regulation 26596471 5 0 0 induces p65 phosphorylation, induces IKK/NF-KB signaling -PAG1 PAG Adaptor/scaffold; Membrane protein, integral Q9NWQ8 55824 8q21.13 human Y181-p 454746 NMVEDCLyETVKEIK PAG molecular association, regulation RASA1(INDUCES) 17389760 2 22 115 -XRCC1 XRCC1 DNA repair, damage P18887 7515 19q13.31 human S418-p 3181471 EEDEASHsGGSGDEA molecular association, regulation PARP1(DISRUPTS) 25477519 1 3 1 -MAPT Tau iso8 ACETYLTRANSFERASE; Acetyltransferase; Cytoskeletal P10636-8 4137 17q21.31 human S198-p 449551 SGDRSGYsSPGSPGT molecular association, regulation WWOX(INDUCES); Tau(INDUCES) 15126504; 16923168 21 15 10 enhances tau aggregation; binding increased by estradiol -Spred1 SPRED1 Inhibitor Q924S8 114715 2|2 E5 mouse Y377-p 18899303 LCAESMLyHCMSDSE Sprouty cell differentiation, altered; signaling pathway regulation 21531714 1 0 0 inhibits the Ras/ERK pathway -Tp63 p63 DNA-binding; Transcription factor O88898 22061 16 B1|16 17.37 cM mouse S160-p 451600 SSTFDALsPSPAIPS apoptosis, induced; signaling pathway regulation 29988075 6 2 0 -Notch1 Notch 1 Membrane protein, integral; Motility/polarity/chemotaxis; Oncoprotein; Receptor, misc.; Transcription factor Q01705 18128 2 A3|2 18.91 cM mouse T2487-p 483083 VPEHPFLtPSPESPD protein degradation; molecular association, regulation; ubiquitination FBXW7(INDUCES) 17646409 5 1 0 -ERBB4 HER4 EC 2.7.10.1; KINASE; Kinase, protein; Membrane protein, integral; Protein kinase, TK; Protein kinase, tyrosine (receptor) Q15303 2066 2q34 human Y1035-p 4825102 FNIPPPIyTSRARID molecular association, regulation STAT1(INDUCES) 18721752 0 1 0 -NFKBIA IkB-alpha DNA-binding; Inhibitor P25963 4792 14q13.2 human S36-p 448204 RHDSGLDsMKDEEYE protein degradation; protein stabilization; molecular association, regulation; phosphorylation; activity, induced; sumoylation; ubiquitination; intracellular localization apoptosis, altered; cell growth, induced; apoptosis, induced; apoptosis, inhibited; transcription, induced; transcription, altered IkB-beta(INDUCES) 10754328; 11502888; 11752211; 12068083; 12085227; 12419817; 12432072; 12527907; 14523047; 15843586; 16007147; 16163708; 16735506; 20696840; 28467781; 33876201; 34558646; 7739562; 7796813; 7878466; 8649784; 8657102; 9252186; 9351830; 9724653; 9734360 99 2 6 -PTPRCAP PTPRCAP Cell surface; Membrane protein, integral Q14761 5790 11q13.2 human S153-p 23136094 RAEEARDsDTEGDLV PTPRCAP protein stabilization 30482149 3 2 1 -DEPTOR DEPTOR Apoptosis Q8TB45 64798 8q24.12 human T295-p 4723863 GYFSSSPtLSSSPPV protein degradation; molecular association, regulation BTRC(INDUCES) 22017875 2 4 0 -Inpp5d SHIP EC 3.1.3.86; Motility/polarity/chemotaxis; Phosphatase, lipid Q9ES52 16331 1 D|1 44.44 cM mouse S441-p 15621804 QGKTRDDsADYIPHD Exo_endo_phos enzymatic activity, induced 20810657 1 1 0 -VRK1 VRK1 EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, CK1; Protein kinase, Ser/Thr (non-receptor) Q99986 7443 14q32.2 human T386-p 1868585000 QTEEAIQtRSRTRKR phosphorylation 32266931 1 1 0 induces phosphorylation of c-Jun and p53 -RPS6KA3 RSK2 EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, AGC; Protein kinase, Ser/Thr (non-receptor) P51812 6197 Xp22.12 human Y529-p 464205 TITKTVEyLHAQGVV Pkinase molecular association, regulation apoptosis, altered; cell motility, induced; cell growth, induced ERK2(INDUCES); ERK1(INDUCES); FGFR3(INDUCES) 17785202; 18156174; 25014166 4 1 4 -LRP2 LRP2 Membrane protein, integral; Motility/polarity/chemotaxis; Receptor, misc. P98164 4036 2q31.1 human S4587-p 767905 WNLFKRKsKQTTNFE receptor internalization, altered; receptor recycling, altered 17555532 1 0 0 -RPS6KB1 p70S6K EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, AGC; Protein kinase, Ser/Thr (non-receptor); Translation P23443 6198 17q23.1 human S394-p 448806 TRQTPVDsPDDSTLS Pkinase_C activity, induced; protein conformation; enzymatic activity, induced 11914378; 17446865; 9271440 17 4 11 -PLCG2 PLCG2 Carbohydrate Metabolism - inositol phosphate; EC 3.1.4.11; Motility/polarity/chemotaxis; Phospholipase P16885 5336 16q23.3 human Y759-p 447941 LYDVSRMyVDPSEIN molecular association, regulation; enzymatic activity, induced LYN(INDUCES) 12780340; 15184383; 30344948; 32184360; 34607960 21 13 227 -PTEN PTEN Carbohydrate Metabolism - inositol phosphate; EC 3.1.3.16; EC 3.1.3.48; EC 3.1.3.67; Motility/polarity/chemotaxis; Nuclear receptor co-regulator; PHOSPHATASE; Phosphatase, lipid; Tumor suppressor P60484 5728 10q23.31 human T366-p 449634 ASSSTSVtPDVSDNE molecular association, regulation; intracellular localization; activity, inhibited RAD52(INDUCES) 16107342; 24047694 7 4 0 facilitates translocation to chromatin and interaction with RAD52 -Adam22 ADAM22 Cell adhesion; Membrane protein, integral; Motility/polarity/chemotaxis Q9R1V6 11496 5 A1|5 3.39 cM mouse S855-p 469109 RFRPRSNsTETLSPA protein stabilization; molecular association, regulation endocytosis, inhibited 14-3-3 epsilon(INDUCES) 34910912 2 15 74 -MAP4 MAP4 Cytoskeletal; Motility/polarity/chemotaxis P27816 4134 3p21.31 human K1028-ac 36298043 GNVQIQNkKVDISKV Tubulin-binding cytoskeletal reorganization 28002468 1 2 0 -NOTCH1 Notch 1 Membrane protein, integral; Motility/polarity/chemotaxis; Oncoprotein; Receptor, misc.; Transcription factor P46531 4851 9q34.3 human K2174-ac 18899510 ACGSKEAkDLKARRK intracellular localization cell growth, induced; apoptosis, inhibited 28377411 2 1 0 -STAT5A STAT5A DNA-binding; Motility/polarity/chemotaxis; Oncoprotein; Transcription factor P42231 443419 sheep T757-p 447766 GEFDLDEtMDVARHV intracellular localization transcription, inhibited 11133982 3 0 0 -Gabbr1 GABBR1 GPCR, family 3; Membrane protein, integral; Membrane protein, multi-pass; Receptor, GPCR Q9Z0U4 81657 20p12 rat K991-ub 59175202 SRVHLLYk_______ receptor recycling, inhibited; protein degradation; intracellular localization 27573246 1 0 0 -Camk2a CAMK2A EC 2.7.11.17; KINASE; Kinase, protein; Protein kinase, CAMK; Protein kinase, Ser/Thr (non-receptor) P11275 25400 18q12.1 rat T306-p 449596 LKGAILTtMLATRNF molecular association, regulation; enzymatic activity, inhibited cytoskeletal reorganization Calmodulin(DISRUPTS) 1324926; 20660727; 2162839 18 10 2 regulate synaptic strength -ADD2 ADD2 Cytoskeletal; Motility/polarity/chemotaxis P35612 119 2p13.3 human S600-p 481589 PAKSAPAsPVQSPAK cell growth, induced; cytoskeletal reorganization 21606488 3 28 1 -SOX10 SOX10 Cell development/differentiation; DNA-binding; Transcription factor P56693 6663 22q13.1 human K357-sm 3875805 VDAKAQVkTETAGPQ molecular association, regulation transcription, inhibited EGR2(DISRUPTS); PAX3(DISRUPTS) 16494873 2 0 0 -PELI1 PELI1 Adaptor/scaffold; EC 6.3.2.-; EC 6.3.2.19; Ligase; UBIQUITIN LIGASE; Ubiquitin conjugating system; Ubiquitin ligase Q96FA3 57162 2p14 human T86-p 7388011 YTLSRAQtVVVEYTH Pellino ubiquitination; enzymatic activity, induced 19264966 2 0 0 -RANGAP1 RANGAP1 GAP; GAP, Ras P46060 5905 22q13.2 human S504-p 1873645604 LMQKAFNsSSFNSNT RanGAP1_C sumoylation; intracellular localization 34110283 1 0 0 WT RANGAP1 rescues nuclear import of NF-ATc1, NF-kB, AP-1 in RanGAP1 (KD), required in various nuclear transport pathways -TRPM8 TRPM8 Channel, cation; Membrane protein, integral; Membrane protein, multi-pass Q7Z2W7 79054 2q37.1 human S9-p 12570903 SFRAARLsMRNRRND activity, induced 20110357 1 0 0 -TGFBR2 TGFBR2 EC 2.7.11.30; KINASE; Kinase, protein; Membrane protein, integral; Oncoprotein; Protein kinase, Ser/Thr (receptor); Protein kinase, TKL P37173 7048 3p24.1 human S409-p 452048 LRLDPTLsVDDLANS PK_Tyr_Ser-Thr enzymatic activity, induced 9155023 1 5 0 -HDAC5 HDAC5 DEACETYLASE; Deacetylase; EC 3.5.1.98; Hydrolase Q9UQL6 10014 17q21.31 human S1108-p 17542307 AAAAREHsPRPAEEP molecular association, regulation; intracellular localization GPS2(INDUCES); SMRT(INDUCES); HDAC3(INDUCES); N-CoR1(INDUCES); TBL1X(INDUCES); TBL1XR1(INDUCES) 24920159 2 10 15 interactions have been defined by quantitative mass spectrometry -EGLN2 EGLN2 EC 1.14.11.29; Oxidoreductase Q96KS0 112398 19q13.2 human S401-p 62873403 KGVQVPVsQPPTPT_ protein degradation; molecular association, regulation; ubiquitination FBXW7(INDUCES) 28036276 1 1 0 -Srebf1 SREBP-1 iso1 DNA-binding; Membrane protein, integral; Membrane protein, multi-pass; Transcription factor P56720-1 78968 10q22 rat S422-p 4785186 RGSSSGGsDSEPDSP protein stabilization; molecular association, regulation; intracellular localization transcription, induced SCAP(INDUCES) 31541353 1 5 0 activates genes involved in de novo lipogenesis -CD36 CD36 Cell adhesion; Membrane protein, integral; Membrane protein, multi-pass P16671 948 7q21.11 human T92-p 23017300 VKQRGPYtYRVRFLA CD36 molecular association, regulation signaling pathway regulation THBS1(DISRUPTS) 22247259 1 1 0 -Sirt7 SIRT7 DEACETYLASE; Deacetylase; EC 3.5.1.-; Nucleolus Q8BKJ9 209011 11|11 E2 mouse S137-p 1871979201 LQKGRPVsAADLSEA SIR2 protein stabilization; acetylation; ubiquitination; intracellular localization; enzymatic activity, induced transcription, induced 33495326 1 1 0 causes deacetylation and relocation of NPM and as a result inhibition of p53 ubiquitination and degradation of p53 -INSR INSR EC 2.7.10.1; KINASE; Kinase, protein; Membrane protein, integral; Protein kinase, TK; Protein kinase, tyrosine (receptor) P06213 3643 19p13.2 human S1221-p 3103703 TTSSDMWsFGVVLWE PK_Tyr_Ser-Thr enzymatic activity, induced 10866039 1 0 0 -IDH2 IDH2 Carbohydrate Metabolism - citrate (TCA) cycle; EC 1.1.1.42; Mitochondrial; Other Amino Acids Metabolism - glutathione; Oxidoreductase P48735 3418 15q26.1 human K413-ac 1204122 VESGAMTkDLAGCIH Iso_dh molecular association, regulation; enzymatic activity, inhibited carcinogenesis, induced; cell growth, induced IDH2(DISRUPTS) 26631723; 28536275; 32457458; 34289383 6 3 5 inhibits substrate (alpha -KG) and co-factor (NADPH) binding: 2-HG for transformation and but not high levels for cytotoxicity ; alters mitochondrial metabolism- increases cellular ROS and glycolysis, decreases IDH2 dimerization -TP53 p53 Activator; DNA-binding; Motility/polarity/chemotaxis; Nuclear receptor co-regulator; Transcription factor; Tumor suppressor P04637 7157 17p13.1 human S371-p 447533 AHSSHLKsKKGQSTS activity, induced; molecular association, regulation DNA(INDUCES) 9315650; 9571186 4 0 0 mutation of S371 showed a small decrease in PKC-mediated activation, but did not abolish the PKC effect -GTF2IRD1 GTF2IRD1 DNA-binding Q9UHL9 9569 7q11.23 human K495-sm 27992502 LGGLRPIkIEPEDLD protein degradation; molecular association, regulation PIAS2(INDUCES); ZMYM5(INDUCES) 23145142 1 2 0 -GSK3B GSK3B EC 2.7.11.1; EC 2.7.11.26; KINASE; Kinase, protein; Protein kinase, CMGC; Protein kinase, Ser/Thr (non-receptor) P49841 2932 3q13.33 human K292-sm 4617400 NPNYTEFkFPQIKAH Pkinase protein stabilization; intracellular localization; phosphorylation; enzymatic activity, induced apoptosis, induced 18949077 1 0 0 nuclear localization, SUMOylation of GSK3B is required for s Y216 phosphorylation, and its kinase activity -NDUFV3 NDUFV3 Energy Metabolism - oxidative phosphorylation; Mitochondrial; Oxidoreductase P56181 4731 21q22.3 human S105-p 4751741 QPSSGREsPRH____ activity, induced cell cycle regulation 24746669 1 17 0 increases mitochondrial respiration for G/2M transition -ACTA1 ACTA1 Cell development/differentiation; Contractile; Cytoskeletal; Motility/polarity/chemotaxis P68133 58 1q42.13 human R256-m1 1876986202 VITIGNErFRCPETL Actin intracellular localization transcription, induced 32997990 1 1 0 -TRAF3 TRAF3 UBIQUITIN LIGASE; Ubiquitin conjugating system; Ubiquitin ligase Q13114 7187 14q32.32 human Y446-p 1869973806 SLYSQPFyTGYFGYK ubiquitination 32779804 1 0 0 -RUNX2 AML3 DNA-binding; Transcription factor Q13950 860 6p21.1 human S118-p 460037 AELVRTDsPNFLCSV Runt protein degradation; protein stabilization; molecular association, regulation; activity, inhibited cell differentiation, inhibited; cell differentiation, induced; transcription, inhibited; transcription, altered CBFB(DISRUPTS) DNA(INDUCES) 12231506; 16443755; 22247071; 29988028 4 2 0 regulate maintenance of osteogenesis and abrogation of adipogenesis; phosphorylation of this site inhibits osteoblastic cell differentiation -Ctnnd1 CTNND1 Actin-binding; Adaptor/scaffold; Cell adhesion; G protein regulator, misc.; Motility/polarity/chemotaxis P30999 12388 2 D|2 49.45 cM mouse T916-p 450454 ERGDHNRtLDRSGDL molecular association, regulation cell adhesion, inhibited 26175155 5 26 7 decreased homophilic binding affinity of E-cadherin -IRAK1 IRAK1 EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, Ser/Thr (non-receptor); Protein kinase, TKL P51617 3654 Xq28 human S373-p 23116180 RFAGSSPsQSSMVAR Pkinase enzymatic activity, induced 29208712 0 1 1 -Cnr1 CNR1 GPCR, family 1; Membrane protein, integral; Membrane protein, multi-pass; Receptor, GPCR P47746 12801 4 A5|4 16.28 cM mouse S430-p 999608 LDNSMGDsDCLHKHA receptor desensitization, induced 24719095 3 3 0 -Gprc5b GPRC5B GPCR, family 3; Membrane protein, integral; Membrane protein, multi-pass; Receptor, GPCR Q923Z0 64297 7|7 F2 mouse Y307-p 6158489 LQENPPNyFDTSQPR molecular association, regulation Fyn(INDUCES) 23169819 1 2 11 induces phosphorylation of Cav1 and inflammatory signaling in adipose tissue -PLEKHG1 PLEKHG1 GEF; GEF, Rac/Rho Q9ULL1 57480 6q25.1 human Y559-p 464047 NEDDEDDyQMFVPSF activity, induced; molecular association, regulation; intracellular localization cytoskeletal reorganization Fyn(INDUCES) 35031323 1 0 2 -MAZ MAZ C2H2-type zinc finger protein; RNA-binding; Transcription factor O97600 100008693 rabbit S187-p 449094 ALEKKRKsKGPYICA protein conformation; activity, inhibited transcription, inhibited DNA(DISRUPTS) 12697757 1 0 0 -KLF6 KLF6 C2H2-type zinc finger protein; DNA-binding Q99612 1316 10p15.2 human K209-ac 459204 CHFNGCRkVYTKSSH zf-C2H2 cell growth, inhibited; transcription, induced 16230382 1 1 0 -PKM PKM Carbohydrate Metabolism - glycolysis and gluconeogenesis; Carbohydrate Metabolism - pyruvate; EC 2.7.1.40; KINASE; Kinase, other; Mitochondrial; Nucleotide Metabolism - purine P14618 5315 15q23 human T328-p 481749 GKPVICAtQMLESMI PK protein stabilization; intracellular localization cell growth, induced; apoptosis, inhibited; transcription, induced 29262861; 30297868 2 3 0 nuclear accumulation; HIF-1a target genes and beta-catenin target genes -Ppp1r1a PPP1R1A Inhibitor; Protein phosphatase, regulatory subunit P19103 58977 7q36 rat S67-p 447758 LKSTLSMsPRQRKKM DARPP-32 activity, inhibited; phosphorylation 21447388 12 14 2 induces PLB dephosphorylation -Cadps CADPS Vesicle Q62717 26989 15p15 rat S7-p 7712501 _MLDPSSsEEESDEI activity, induced exocytosis, altered 19460754 1 2 0 -RHOT1 RHOT1 EC 3.6.5.-; G protein; G protein, monomeric; G protein, monomeric, Rho; Hydrolase; Membrane protein, integral; Mitochondrial Q8IXI2 55288 17q11.2 human K572-ub 32005103 PSKDIFVkLTTMAMY protein degradation; intracellular localization autophagy, induced 34152608 2 0 0 induces mitophagy by recruiting Parkin to mitochondria -SCML2 SCML2 Transcription factor Q9UQR0 10389 Xp22.13 human S570-p 478158 MYIHTSVsQDFSRSV protein stabilization; molecular association, regulation DDB1(DISRUPTS) 37353627 1 4 13 -CHD4 CHD-4 DNA-binding; EC 3.6.4.12; Helicase Q14839 1108 12p13.31 human S1349-p 481897 QVNYNDGsQEDRDWQ DUF1087 molecular association, regulation; intracellular localization DNA(NOT_REPORTED) 21219611 1 12 17 required for efficient repair of double strand DNA breaks -E2F1 E2F1 DNA-binding; Transcription factor Q01094 1869 20q11.22 human S332-p 447868 TDSATIVsPPPSSPP molecular association, regulation; intracellular localization; protein conformation cell cycle regulation; transcription, induced; transcription, altered; cell growth, altered PRB1(INDUCES); Rb(DISRUPTS); E4(INDUCES) 20616879; 26724859; 27175585; 8087847 5 0 0 -Tbx2 TBX2 DNA-binding; Transcription factor Q60707 21385 11 C|11 51.34 cM mouse S675-p 1308916 GPSRGALsPSGSAKE activity, induced; protein stabilization; intracellular localization transcription, inhibited 18025091 1 6 0 relocalizes into nuclei after UV radiation -HSP90AB1 HSP90B Chaperone; Heat shock protein P08238 3326 6p21.1 human Y192-p 459272 LKEDQTEyLEERRVK HSP90 protein conformation 23867252 1 7 178 phosphorylation induces altered conformation and governs drug specificity. -LAT LAT Adaptor/scaffold; Membrane protein, integral O43561 27040 16p11.2 human Y156-p 448003 ADEDEDDyHNPGYLV LAT molecular association, regulation PLCG1(INDUCES) 33929486 4 0 1 -Camkk2 CAMKK2 Autophagy; EC 2.7.11.17; KINASE; Kinase, protein; Protein kinase, Other; Protein kinase, Ser/Thr (non-receptor) O88831 83506 12q16 rat T482-p 21336500 KHIPSLAtVILVKTM enzymatic activity, induced 21859090 2 2 0 -PDHA1 PDHA1 Amino Acid Metabolism - valine, leucine and isoleucine biosynthesis; Carbohydrate Metabolism - butanoate; Carbohydrate Metabolism - citrate (TCA) cycle; Carbohydrate Metabolism - glycolysis and gluconeogenesis; Carbohydrate Metabolism - pyruvate; EC 1.2.4.1; Mitochondrial; Oxidoreductase P08559 5160 Xp22.12 human K385-ac 1204112 RGANQWIkFKSVS__ enzymatic activity, inhibited 34518519 1 3 1 metabolic reprogramming associated with renal ?brosis -XRCC6 Ku70 DNA repair, damage; DNA-binding; EC 3.6.4.-; EC 4.2.99.-; Helicase; Nuclear receptor co-regulator; RNA-binding P12956 2547 22q13.2 human K539-ac 458921 PDYNPEGkVTKRKHD Ku_C molecular association, regulation apoptosis, induced BAX(DISRUPTS) DNA(DISRUPTS) 15023334; 17545612 2 2 0 -Ctnnb1 CTNNB1 Actin-binding; Cell adhesion; Motility/polarity/chemotaxis; Nuclear receptor co-regulator; Oncoprotein; Transcription factor Q02248 12387 9 F4|9 72.19 cM mouse S37-p 447582 YLDSGIHsGATTTAP protein degradation; ubiquitination carcinogenesis, inhibited 15308623; 34642308; 9233789 110 3 12 -Ets1 Ets-1 DNA-binding; Motility/polarity/chemotaxis; Oncoprotein; Transcription factor P27577 23871 9 A4|9 17.97 cM mouse S41-p 22650305 VPLLTPSsKEMMSQA protein conformation transcription, induced CBP(INDUCES) 20534573 1 0 0 -Bmal1 BMAL1 DNA-binding; Transcription factor Q9WTL8 11865 7 F1|7 59.17 cM mouse S42-p 25230400 CNRKRKGsATDYQLD molecular association, regulation; methylation transcription, inhibited DNA(DISRUPTS) 35338256 4 3 2 induces H3 methylation -Map3k5 ASK1 EC 2.7.11.25; KINASE; Kinase, protein; Protein kinase, STE; Protein kinase, Ser/Thr (non-receptor) O35099 26408 10|10 A3 mouse S993-p 7449405 SSEYGSVsPDTELKA enzymatic activity, induced 33108364 1 4 0 -PRKDC DNAPK DNA repair, damage; EC 2.7.11.1; KINASE; Kinase, protein; Nucleolus; Protein kinase, Ser/Thr (non-receptor); Protein kinase, atypical P78527 5591 8q11.21 human T2647-p 448713 QQHDFTLtQTADGRS DNAPKcs_CC5 molecular association, regulation; protein conformation; phosphorylation DNA repair, induced; chromatin organization, altered; cell growth, altered SLC25A5(DISRUPTS) DNA(DISRUPTS) 17189255; 22592045; 24687855; 36727301 12 12 8 increases survival in ionizing radiation and repairing double strand DNA breaks; cell survival induced, induces removal of cisplatin adducts from DNA, induces end processing; phosphorylates Artemis -ATXN3 ataxin-3 DEUBIQUITINASE; DNA repair, damage; EC 3.4.19.12; Protease; Transcription regulation; Ubiquitin-specific protease P54252 4287 14q32.12 human S335-p 9441001 SDLGDAMsEEDMLQA UIM activity, induced; protein stabilization; intracellular localization transcription, altered 19542537 1 0 0 -CDCA5 CDCA5 Cell cycle regulation Q96FF9 113130 11q13.1 human S209-p 3208965 DMTLPGIsPPPEKQK Sororin molecular association, regulation cell cycle regulation; carcinogenesis, altered; cell growth, altered H2A.1(DISRUPTS); SMC3(DISRUPTS) 20551060; 21878504 2 17 0 -H3c1 H3 DNA-binding P68433 360198 13|13 A3.1 mouse K23-ac 458999 PRKQLATkAARKSAP Histone chromatin organization, altered 20067909 32 28 422 -FZR1 FZR1 UBIQUITIN LIGASE; Ubiquitin conjugating system Q9UM11 51343 19p13.3 human S40-p 3215931 PASSPVSsPSKHGDR protein stabilization; molecular association, regulation; activity, inhibited; phosphorylation apoptosis, induced APC(DISRUPTS); CDC27(DISRUPTS); APC1(DISRUPTS); CDC23(DISRUPTS) 18818692; 26083744; 26150388; 27080259; 30498084 5 13 2 inhibits cyclin B1 degradation; O-GlcNAcylation of FZR1 antagonizes its phosphorylation ; AURKA stabilization -PTK6 Brk EC 2.7.10.2; KINASE; Kinase, protein; Protein kinase, TK; Protein kinase, tyrosine (non-receptor) Q13882 5753 20q13.33 human Y342-p 450274 RLIKEDVyLSHDHNI PK_Tyr_Ser-Thr phosphorylation; enzymatic activity, induced signaling pathway regulation Brk(INDUCES) 12121988; 14676834; 34145060 4 4 45 induces DOK1 phosphorylation; regulates TCR/CD28 signaling -Skor1 SKOR1 Q8BX46 207667 9|9 B mouse Y234-p 1881001402 HRTPDAKyTQPDAAN molecular association, regulation carcinogenesis, induced; cell motility, induced; cell growth, induced; transcription, induced; cytoskeletal reorganization; signaling pathway regulation SMAD3(DISRUPTS) 36620935 1 0 0 induces Smad2/3 signaling -INCENP INCENP Cell cycle regulation; EC 2.7.11.1 Q9NQS7 3619 11q12.3 human S91-p 4273495 RRLSRRKsRSSQLSS molecular association, regulation; intracellular localization cell cycle regulation; cell growth, induced KIF20A(INDUCES) 33355621 2 4 3 alters CPC localization -SNAP91 SNAP-91 Vesicle O60641 9892 6q14.2 human S313-p 454326 SPATTVTsPNSTPAK molecular association, regulation PLD1(INDUCES) 21296491 1 10 5 -Optn optineurin Inhibitor Q8K3K8 71648 2 A1|2 3.15 cM mouse S476-p 9511914 AQMEVYCsDFHAERA CC2-LZ autophagy, induced 33931895 3 2 0 regulates mitochondrial homeostasis and pluripotency -SMARCAL1 SMARCAL1 EC 3.6.1.-; EC 3.6.4.-; Helicase Q9NZC9 50485 2q35 human S889-p 29606708 IYDLFQKsFEKEGSD enzymatic activity, induced 24150942 1 2 0 regulates ATPase activity, SMARCAL1 fork regression activity, -Scn2a SCN2A Channel, sodium; Membrane protein, integral; Membrane protein, multi-pass P04775 24766 3q21 rat S1126-p 6003507 TEEFSSEsDMEESKE Na_trans_assoc intracellular localization 19064667 1 0 0 regulates SCN2A accumulation at the axonal initial segment (AIS) and interaction with ankyrin G -MMP14 MMP14 EC 3.4.24.80; Membrane protein, integral; Motility/polarity/chemotaxis; Protease P50281 4323 14q11.2 human T567-p 7992400 FFFRRHGtPRRLLYC DUF3377 molecular association, regulation; intracellular localization; phosphorylation cell motility, induced; cell growth, induced; cell adhesion, induced; cell motility, altered; cell growth, altered ITGA5(INDUCES) 19458085; 22002060; 28655772 4 0 0 promote ovarian cancer intraperitoneal metastatic dissemination; increases cell migration and invasion ; required for MMP14 internalization and trafficking -JUN Jun Oncoprotein; Transcription factor P05412 3725 1p32.1 human T239-p 450450 VPEMPGEtPPLSPID Jun molecular association, regulation; ubiquitination cell motility, inhibited; transcription, inhibited FBXW7(INDUCES); FBXW7(DISRUPTS) DNA(DISRUPTS) 16023596; 21860413; 24632621 8 14 19 -WNK4 WNK4 EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, Other; Protein kinase, Ser/Thr (non-receptor) Q96J92 65266 17q21.2 human S335-p 456207 KRASFAKsVIGTPEF Pkinase enzymatic activity, induced 25542968 5 11 3 required for NCCT activation -TFEB TFEB DNA-binding; Transcription factor P19484 7942 6p21.1 human K116-ac 56403903 SPAQGSPkPPPAASP MITF_TFEB_C_3_N protein degradation; molecular association, regulation autophagy, inhibited; transcription, inhibited TFEB(DISRUPTS) DNA(DISRUPTS) 27209302; 31750630 3 1 0 suppresses TFEB transcriptional activity, knocking down dGcn5 in Drosophila eyes reduced hTau aggregation -CELF1 CELF1 Cell development/differentiation; RNA processing; RNA-binding Q92879 10658 11p11.2 human S52-p 25733984 INVLRDRsQNPPQSK RRM_1 RNA splicing, altered 24151077 1 1 7 splicing regulation in diabetes -XRCC1 XRCC1 DNA repair, damage P18887 7515 19q13.31 human S475-p 451509 IDIEGVQsEGQDNGA molecular association, regulation; intracellular localization PARP1(DISRUPTS); Pnk1(INDUCES) 15066279; 25477519 3 9 0 -TBXA2R TXA2-R iso2 GPCR, family 1; Membrane protein, integral; Membrane protein, multi-pass; Receptor, GPCR P21731-2 6915 19p13.3 human S239-p 469628 AQQRPRDsEVEMMAQ 7tm_1 molecular association, regulation; receptor desensitization, altered; receptor internalization, altered ARRB2(INDUCES) 16956790 1 0 0 -Psmc5 RPT6 Nuclear receptor co-regulator; Proteasome complex; Ubiquitin conjugating system P62196 19184 11|11 E1 mouse S120-p 483970 RVALRNDsYTLHKIL Prot_ATP_ID_OB enzymatic activity, induced 33658307 11 7 0 induces peptidase and ATPase activity -AGO2 AGO2 EC 3.1.26.n2; RNA processing; RNA-binding Q9UKV8 27161 8q24.3 human S798-p 17533105 VRCTRSVsIPAPAYY Piwi molecular association, regulation; activity, inhibited 26443379 2 1 0 abrogates association with RNA granules- P-bodies and stress granules, silencing activity is mildly affected -SRC Src EC 2.7.10.2; KINASE; Kinase, protein; Oncoprotein; Protein kinase, TK; Protein kinase, tyrosine (non-receptor) P00523 396442 chicken Y527-p 448235 FTSTEPQyQPGENL_ molecular association, regulation; enzymatic activity, inhibited; phosphorylation neural plasticity; cell motility, altered; cytoskeletal reorganization; cell adhesion, altered; cell growth, altered CSK(INDUCES); CSK(DISRUPTS) 11689444; 11909938; 1379736; 16024778; 17855352; 18614016; 2474754; 3103925; 3103926; 34616310; 7680096; 7687537 153 24 968 -Apba2 APBA2 Adaptor/scaffold P98084 11784 7 C|7 34.65 cM mouse S239-p 7151800 AEIKMSLsMTSITSA molecular association, regulation APP(INDUCES) 19222704 1 1 0 -SLC7A5 SLC7A5 Membrane protein, integral; Membrane protein, multi-pass; Transporter; Transporter, SLC family Q01650 8140 16q24.2 human K30-ub 6778622 REKMLAAkSADGSAP protein degradation endocytosis, induced 31728037 1 11 62 PMA-induced endocytosis -IRF3 IRF3 DNA-binding; Transcription factor Q14653 3661 19q13.33 human S396-p 449028 NTVDLHIsNSHPLSL protein degradation; protein stabilization; molecular association, regulation; activity, inhibited; enzymatic activity, induced; activity, induced; intracellular localization; protein conformation carcinogenesis, induced; autophagy, induced; apoptosis, induced; transcription, induced; transcription, altered CALCOCO2(INDUCES); IRF3(INDUCES); UBE3C(DISRUPTS); CBP(INDUCES) DNA(INDUCES) 12524442; 14703513; 18272581; 18440553; 19153595; 20511230; 23478265; 24371060; 25070846; 25636800; 27992402; 30842273; 32123095; 33411856; 33850055; 33883226; 33990776; 34379517; 34619149; 34965427; 35879450; 35948267; 36113429; 36417850; 36538592; 37330913; 9566918 75 6 0 GPR108 and Smurf1 mediated degradation requires NDP52; NDP52-dependent autophagic degradation of phosphorylated IRF3; GPR108 interacts with Smurf1, followed by the recruitment of IRF3 during viral infection -Cdk16 CDK16 Cell cycle regulation; EC 2.7.11.22; KINASE; Kinase, protein; Motility/polarity/chemotaxis; Protein kinase, CMGC; Protein kinase, Ser/Thr (non-receptor) Q04735 18555 X A1.3|X 16.18 cM mouse S110-p 453449 NHPPRKIsTEDINKR molecular association, regulation CCNYL1(INDUCES) 26305884 2 31 29 -ACO1 IREB1 Carbohydrate Metabolism - citrate (TCA) cycle; Carbohydrate Metabolism - glyoxylate and dicarboxylate; EC 4.2.1.3; Endoplasmic reticulum; Lyase; RNA-binding; Translation P21399 48 9p21.1 human S711-p 455225 REFNSYGsRRGNDAV Aconitase_C activity, inhibited 15636585 3 0 0 -Smad7 SMAD7 DNA-binding; Transcription factor O35253 17131 18|18 E3 mouse T96-p 15613800 EADLKALtHSVLKKL MH1 protein degradation; molecular association, regulation; enzymatic activity, inhibited apoptosis, inhibited; transcription, inhibited; signaling pathway regulation 29700281 2 0 0 negatively regulates and ASK1/TGF-beta/p53 signaling pathways.; inhibits MELK activity induces degradation -Oprd1 DOR-1 GPCR, family 1; Membrane protein, integral; Membrane protein, multi-pass; Receptor, GPCR P32300 18386 4 D2.3|4 64.78 cM mouse T361-p 448551 RERVTACtPSDGPGG intracellular localization 21220103 4 1 0 -EIF3J eIF3-alpha Translation; Translation initiation O75822 8669 15q21.1 human S127-p 3177700 LKKLQEEsDLELAKE eIF3_subunit molecular association, regulation translation, induced eIF3-eta(INDUCES); eIF3-zeta(INDUCES); EIF3C(INDUCES) 25887626 1 35 8 -AR AR DNA-binding; Nuclear receptor; Transcription factor P10275 367 Xq12 human Y225-p 1243004 PTSSKDNyLGGTSTI Androgen_recep transcription, induced 23906537 1 1 0 PSA expression -EPOR EPOR Membrane protein, integral; Receptor, cytokine P19235 2057 19p13.2 human Y456-p 455532 PPHLKYLyLVVSDSG molecular association, regulation apoptosis, inhibited SHIP(INDUCES); SOCS3(INDUCES) 10660611; 12027890; 14662339 8 0 0 -NR3C2 MCR DNA-binding; Nuclear receptor P08235 4306 4q31.23 human S936-p 1875398906 DSMHDLVsDLLEFCF Hormone_recep intracellular localization 34847273 1 0 0 -SNAP25 SNAP-25 Vesicle P60880 6616 20p12.2 human T138-p 449875 GGFIRRVtNDARENE SNAP-25 molecular association, regulation exocytosis, induced STX1A(DISRUPTS); SYT1(DISRUPTS) 17325194; 22311984 7 5 3 -XRCC1 XRCC1 DNA repair, damage P18887 7515 19q13.31 human K298-ac 474774 AQGAVTGkPRGEGTE protein degradation 31043584 1 3 6 -RIPK1 RIPK1 EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, Ser/Thr (non-receptor); Protein kinase, TKL Q13546 8737 6p25.2 human S357-p 1868502603 GMGPVEEsWFAPSLE molecular association, regulation apoptosis, inhibited RIPK3(DISRUPTS) 32320653 1 1 0 -CYCS CYCS Apoptosis; Mitochondrial; Oxidoreductase; PHOSPHATASE; Protein phosphatase, Ser/Thr (non-receptor) P99999 54205 7p15.3 human Y47-p 3416311 KTGQAPGySYTAANK Cytochrom_C enzymatic activity, inhibited apoptosis, inhibited 32781572 1 0 3 inhibits cytochrome c oxidase activity -LIG1 LIG1 DNA repair, damage; EC 6.5.1.1; Ligase P18858 3978 19q13.33 human S91-p 2999200 ALDCSQVsPPRPATS molecular association, regulation; intracellular localization; phosphorylation cell growth, altered RFC1(INDUCES); RAD17(DISRUPTS) 12851383; 19223468 3 10 1 primes other LIG1 phosphorylations; regulates DNA replication and repair -CYLD CYLD DEUBIQUITINASE; EC 3.4.19.12; Protease; Tumor suppressor; Ubiquitin conjugating system; Ubiquitin-specific protease Q9NQC7 1540 16q12.1 human S568-p 1874990002 LAFGGYLsEVVEENT ubiquitination; enzymatic activity, induced signaling pathway regulation 34610306 1 1 0 induces RIPK2 deubiquitination, and NOD2 signaling -SOX2 SOX2 Cell development/differentiation; DNA-binding; Transcription factor P48431 6657 3q26.33 human T256-p 1883303000 SSSPPVVtSSSHSRA phosphorylation 37349645 1 0 0 primes phosphorylation at S251 -KCNH2 Kv11.1 Channel, potassium; Membrane protein, integral; Membrane protein, multi-pass; Motility/polarity/chemotaxis Q12809 3757 7q36.1 human S283-p 4696779 CASVRRAsSADDIEA activity, induced; molecular association, regulation; activity, inhibited signaling pathway regulation 14-3-3 eta(INDUCES) 10488078; 10837251; 11953308 3 5 0 -Syngap1 SynGAP GAP; GAP, Ras F6SEU4 240057 17|17 A3.3 mouse T790-p 33636249 MARLPSPtKEKPPPP DUF3498 activity, inhibited 25533468 1 2 6 S788D and T790D mutations inhibit Rap2 GAP and HRas GAP activities of SynGAP -DNMT1 DNMT1 Amino Acid Metabolism - cysteine and methionine; Cell development/differentiation; EC 2.1.1.37; METHYLTRANSFERASE; Methyltransferase; Methyltransferase, DNA; Transcription regulation P26358 1786 19p13.2 human K1135-sm 12726301 SEPEIEIkLPKLRTL enzymatic activity, induced DNA(INDUCES) 19450230 1 0 0 -YY1 YY1 C2H2-type zinc finger protein; Cell development/differentiation; Transcription factor P25490 7528 14q32.2 human S184-p 476106 GKKSGKKsYLSGGAG molecular association, regulation DNA(INDUCES) 23226345 2 3 1 -HCN4 HCN4 Channel, cation; Membrane protein, integral; Membrane protein, multi-pass Q9Y3Q4 10021 15q24.1 human Y531-p 1240811 RRQYQEKyKQVEQYM activity, induced 17977941 1 0 0 -Homer2 HOMER2 Actin-binding; Adaptor/scaffold Q9QWW1 26557 7|7 D3 mouse S216-p 51633301 EQWKRQFsICRDEND molecular association, regulation mGluR5(DISRUPTS); GluR5(DISRUPTS) 26670047; 36973011 2 0 0 -Camk2d CAMK2D EC 2.7.11.17; KINASE; Kinase, protein; Protein kinase, CAMK; Protein kinase, Ser/Thr (non-receptor) Q6PHZ2 108058 3|3 G1 mouse T287-p 450982 SMMHRQEtVDCLKKF apoptosis, induced 26726877 15 32 148 myocardial necroptosis, inflammation -Dcp1a DCP1A EC 3.-.-.-; Hydrolase; RNA processing; Transcription, coactivator/corepressor Q91YD3 75901 14 B|14 18.75 cM mouse S339-p 3213297 LPLSPVLsPTLPAEA molecular association, regulation DCP2(INDUCES) 23637887 3 25 7 -SERPINA3 SERPINA3 Secreted; Secreted, signal peptide P01011 12 14q32.13 human K421-ac 464675 MSKVTNPkQA_____ molecular association, regulation DNA(INDUCES) 7782318 1 0 0 -CCR7 CCR7 GPCR, family 1; Membrane protein, integral; Membrane protein, multi-pass; Motility/polarity/chemotaxis; Receptor, GPCR P32248 1236 17q21.2 human T374-p 455289 SVEAETTtTFSP___ phosphorylation 15054093 1 0 0 ERK1/2 phosphorylation -FEN1 FEN1 DNA repair, damage; DNA-binding; Deoxyribonuclease; EC 3.1.-.-; Nuclear receptor co-regulator; Nucleolus; Ribonuclease P39748 2237 11q12.2 human K200-sc 33357717 HLTASEAkKLPIQEF XPG_I molecular association, regulation; methylation cell cycle regulation; DNA repair, induced RAD1(INDUCES); HUS1(INDUCES) 32783654 1 1 0 R192 methylation inhibits succinylation -NFKB1 NFkB-p105 iso2 DNA-binding; Transcription factor P19838-2 4790 4q24 human Y82-p 1880539208 SEKNKKSyPQVKICN molecular association, regulation transcription, altered DNA(INDUCES) 36534507 1 0 0 -Wasf1 WAVE1 Cytoskeletal; Motility/polarity/chemotaxis Q5BJU7 rat S310-p 4764996 LIENRPQsPAAGRTP intracellular localization cytoskeletal reorganization 19460862 4 8 0 -IKBKG IKKG Adaptor/scaffold; Protein kinase, regulatory subunit Q9Y6K9 8517 Xq28 human K309-ub 486355 KAQADIYkADFQAER CC2-LZ ubiquitination apoptosis, inhibited; transcription, induced; signaling pathway regulation 14651848; 19136968; 19223549; 21811235; 23453807 7 8 0 regulates NF-kB ignaling and mitochondrial integrity; activation of TAK1 IKK and NF-kB after genotoxic stress -MTA1 MTA1 Motility/polarity/chemotaxis; Nuclear receptor co-regulator; Transcription, coactivator/corepressor Q13330 9112 14q32.33 human K509-sm 25171014 PINSAAIkAECTARL MTA_R1 transcription, inhibited 21965678 2 0 0 -SPHK2 SPHK2 EC 2.7.1.91; Kinase, lipid; Lipid Metabolism - sphingolipid Q9NRA0 56848 19q13.33 human S387-p 477181 PATVEPAsPTPAHSL cell motility, altered 17311928 1 11 0 -Erbb3 HER3 EC 2.7.10.1; KINASE; Kinase, protein; Membrane protein, integral; Oncoprotein; Protein kinase, TK; Protein kinase, tyrosine (receptor) Q62799 29496 7q11 rat Y1051-p 449859 LLSPSSGyMPMNQSS molecular association, regulation; phosphorylation PIK3CB(INDUCES); PIK3R1(INDUCES) 11546794 3 2 20 induces phosphorylation of Akt1. -EEF1A1 EEF1A1 Nucleolus; Translation; Translation elongation P68104 1915 6q13 human K318-m2 12193411 NVKNVSVkDVRRGNV GTP_EFTU_D2 molecular association, regulation L3MBTL iso4(INDUCES) 23583077 0 2 3 -CCNT1 CCNT1 Cell cycle regulation; Transcription initiation complex O60563 904 12q13.11-q13.12 human K380-ac 25174701 ISQKQNSkSVPSAKV molecular association, regulation; enzymatic activity, induced transcription, induced BCDIN3(DISRUPTS); HEXIM1(DISRUPTS); BRD4(INDUCES) RNA(DISRUPTS) 19387490; 22084242 3 1 0 Interaction with BRD4 disrupts interaction with HEXIM1 and 7SK snRNA; enhances CDK9/cyclin T1 transcriptional activity, disrupting HEXIM1 and BCDIN3 association -TUBB3 TUBB3 Cytoskeletal; Motility/polarity/chemotaxis Q13509 10381 16q24.3 human S444-p 451154 YEDDEEEsEAQGPK_ cytoskeletal reorganization 26586574 3 0 2 microtubule stabilization, affects cytokinesis through TUBB3 S444 phosphorylation, -PLK1 PLK1 EC 2.7.11.21; KINASE; Kinase, protein; Protein kinase, Other; Protein kinase, Ser/Thr (non-receptor) P53350 5347 16p12.2 human T210-p 448139 YDGERKKtLCGTPNY Pkinase protein stabilization; molecular association, regulation; ubiquitination; intracellular localization; phosphorylation; enzymatic activity, induced cell cycle regulation; carcinogenesis, induced; carcinogenesis, inhibited; cell motility, induced; transcription, altered; DNA repair, induced; autophagy, induced; cell growth, induced; chromatin organization, altered; cytoskeletal reorganization CHFR(DISRUPTS); PLK1(DISRUPTS) 10980711; 11854496; 12207013; 15713655; 18615013; 22281053; 24349352; 24844881; 25660017; 26114094; 26206521; 26242183; 27002159; 27068477; 27721411; 30021153; 30626720; 31597699; 32060423; 33771996; 33805672; 34140642; 34197606; 34260926; 34758324; 34759346; 34775484; 36231009 59 31 45 -Pdx1 PDX1 DNA-binding; Transcription factor P52947 29535 12p11 rat S66-p 458402 QGSPPDIsPYEVPPL activity, induced; molecular association, regulation transcription, induced p300(INDUCES) 15001545 3 0 0 -NFATC1 NFAT2 DNA-binding; Transcription factor O95644 4772 18q23 human S256-p 1869090802 ESWLGARsSRPASPC activity, induced carcinogenesis, induced; cell motility, induced; transcription, induced 31730483 1 1 0 multiple sites mutatnt -HNRNPK hnRNP K RNA splicing; RNA-binding; Spliceosome P61978 3190 9q21.32 human R296-m2 476739 PPPPPPGrGGRGGSR protein stabilization; phosphorylation cell motility, induced 17191129; 31110205 3 6 8 -Rhbdf2 RHBDL6 Membrane protein, integral; Membrane protein, multi-pass Q80WQ6 217344 11|11 E2 mouse S83-p 4751502 PGFRRQAsLSQSIRK molecular association, regulation 29045841 1 30 35 recruitment- co-immunoprecipitation with 14-3-3 proteins; impaired TACE shedding on the cell surface -KAT7 MYST2 ACETYLTRANSFERASE; Acetyltransferase; EC 2.3.1.48; Nuclear receptor co-regulator; Transcription, coactivator/corepressor O95251 11143 17q21.33 human T331-p 18911980 LRLQGQItEGSNMIK protein stabilization; acetylation; ubiquitination cell growth, induced 33014433 2 3 0 inhibits ubiquitination mediated degradation -FOXC2 FOXC2 Apoptosis; Cell development/differentiation; DNA-binding; Transcription factor Q99958 2303 16q24.1 human S288-p 3210591 SPPGGELsPGAGRAG molecular association, regulation transcription, altered DNA(INDUCES) 23878394 1 8 0 implicated in vascular remodeling in vivo -HSF1 HSF1 DNA-binding; Transcription factor Q00613 3297 8q24.3 human S307-p 449046 EPPSPPQsPRVEEAS Vert_HS_TF protein degradation; sumoylation; molecular association, regulation; intracellular localization; activity, inhibited; phosphorylation transcription, induced; transcription, inhibited 14-3-3 epsilon(INDUCES) 12646186; 12917326; 16624816; 25679764; 25963659; 33493517; 8940068; 9535852 26 56 3 -Grik5 GluR KA2 Channel, ligand-gated; Membrane protein, integral; Membrane protein, multi-pass Q63273 24407 1q21 rat S859-p 27535800 AVSCRKTsRSRRRRR molecular association, regulation PSD-95(DISRUPTS) 23288040 1 0 0 necessary for KAR-LTD; increases expression of KARs at the plasma membrane; reduced at dendritic spines; increases lateral mobility of KARs -CAPN2 CAPN2 EC 3.4.22.53; Motility/polarity/chemotaxis; Protease P17655 824 1q41 human T370-p 451304 GNWRRGStAGGCRNY Calpain_III activity, inhibited cell motility, altered 11909964 2 0 0 -Plcg1 PLCG1 Carbohydrate Metabolism - inositol phosphate; EC 3.1.4.11; Motility/polarity/chemotaxis; Phospholipase P10686 25738 3q42 rat Y783-p 447667 EGRNPGFyVEANPMP intracellular localization; enzymatic activity, induced 1708307; 17113383; 19179337; 20164676 92 42 558 -MCM2 MCM2 DNA-binding; EC 3.6.4.12 P49736 4171 3q21.3 human S13-p 473057 ESFTMASsPAQRRRG molecular association, regulation chromatin organization, altered DNA(INDUCES) 16446360 2 33 5 MMCM2 phosphorylated forms are differentially bound to chromatin. -Tfeb TFEB DNA-binding; Transcription factor Q9R210 21425 17 C|17 23.99 cM mouse S141-p 3181628 AGNSAPNsPMAMLHI MITF_TFEB_C_3_N intracellular localization autophagy, induced; transcription, induced 35948663 13 12 0 -Gja1 GJA1 Channel, misc.; Membrane protein, integral; Membrane protein, multi-pass; Motility/polarity/chemotaxis P08050 24392 20q11 rat S368-p 447813 QRPSSRAsSRASSRP activity, induced; intracellular localization; activity, inhibited cell motility, induced; cell growth, induced 10871288; 12417300; 29021339; 30740090; 34428599; 34698450 57 8 1 -GRB10 GRB10 Adaptor/scaffold Q13322 2887 7p12.1 human S428-p 455333 STPVRSVsENSLVAM BPS protein stabilization 21659604 2 8 0 -GPNMB GPNMB Membrane protein, integral Q14956 10457 7p15.3 human S542-p 12738565 VVRSKGLsVFLNRAK carcinogenesis, induced; cell motility, induced; cell growth, induced; transcription, altered 34327762 1 6 0 -Prkaa2 AMPKA2 Autophagy; EC 2.7.11.1; EC 2.7.11.27; EC 2.7.11.31; KINASE; Kinase, protein; Protein kinase, CAMK; Protein kinase, Ser/Thr (non-receptor) Q09137 78975 5q34 rat S491-p 450432 STPQRSCsAAGLHRP AdenylateSensor enzymatic activity, inhibited 17032173 13 12 2 -Map2 MAP2 iso3 Cytoskeletal; Motility/polarity/chemotaxis P15146-3 25595 9q32 rat K282-ac 62495502 GILVPSEkKVAIIRT cytoskeletal reorganization 28002468 1 1 0 -Sstr2 SSTR2 GPCR, family 1; Membrane protein, integral; Membrane protein, multi-pass; Receptor, GPCR P30680 rat T356-p 12577701 RLNETTEtQRTLLNG activity, induced; intracellular localization; receptor internalization, altered signaling pathway regulation 20051480; 21795688 6 0 0 Dephosphorylation is initiated directly after receptor activation at or near the plasma membrane; leads to disruption of the ?-arrestin- GPCR complex -POLB POLB DNA repair, damage; DNA replication; EC 2.7.7.7; Lyase; Transferase P06746 5423 8p11.21 human K244-ub 56841100 GVCQLPSkNDEKEYP DNA_pol_B_palm protein degradation; ubiquitination 25423885 1 0 0 -DPYSL2 CRMP-2 iso3 Microtubule-binding; Motility/polarity/chemotaxis NP_001184222 1808 8p21.2 human T614-p 448083 PVCEVSVtPKTVTPA carcinogenesis, altered; cell motility, altered 24036111 16 63 34 -Fosl2 FRA2 DNA-binding; Transcription factor P47930 14284 5 B1|5 17.33 cM mouse S320-p 4707550 QSSDSLNsPTLLAL_ protein stabilization cell differentiation, inhibited 23807221 2 14 11 -Smo SMO Cell development/differentiation; GPCR, Fz/Smo family; Membrane protein, integral; Membrane protein, multi-pass; Oncoprotein; Receptor, GPCR P56726 319757 6 A3.3|6 12.36 cM mouse T644-p 1872776122 LPQDVSVtPVATPVP molecular association, regulation transcription, induced PKACA(INDUCES) 33886552 1 1 0 -Pecam1 PECAM-1 Cell adhesion; Cell development/differentiation; Membrane protein, integral; Motility/polarity/chemotaxis Q08481 18613 11|11 E1 mouse Y679-p 448759 PQNMDVEyTEVEVSS molecular association, regulation SHP-2(INDUCES); SHP-1(INDUCES) 9624175 9 0 44 Y679 A.K.A. Y663 -TUBB5 TUBB Cytoskeletal; Motility/polarity/chemotaxis Q2KJD0 cow Y281-p 15406726 TSRGSQQyRALTVPE Tubulin_C cytoskeletal reorganization 19631231 0 1 20 -Cyp2c7 CYP2C39 EC 1.14.14.1; Oxidoreductase P05179 29298 1q31 rat K200-ac 4611500 EMLTFMEkVNENLKI p450 cell differentiation, induced; transcription, induced 18834332 1 0 0 Could be necessary for full differentiation of acinar cells -Ndufa1 NDUFA1 EC 1.6.5.3; EC 1.6.99.3; Energy Metabolism - oxidative phosphorylation; Membrane protein, integral; Mitochondrial; Oxidoreductase Q9WU08 100689328 hamster S55-p 486441 MERDRRVsGVNRYYV MWFE enzymatic activity, induced 17931954 1 1 0 S55 contributes to complex assembly and enzymatic activation. -TET2 TET2 EC 1.14.11.n2; Oxidoreductase; Tumor suppressor Q6N021 54790 4q24 human Y1964-p 1870020001 HETSEPTyLRFIKSL activity, induced; molecular association, regulation; phosphorylation cell differentiation, induced; signaling pathway regulation KLF1(INDUCES) 30944118 1 0 0 -MCRIP1 FAM195B C9JLW8 348262 17q25.3 human S21-p 486127 KRTSSPRsPPSSSEI FAM195 molecular association, regulation transcription, induced CTBP1(DISRUPTS) 25728771 1 46 2 freed CtBP binds to ZEB1, regulates epithelial-mesenchymal transition (EMT). -MTHFR MTHFR Cofactor and Vitamin Metabolism - one carbon pool by folate; EC 1.5.1.20; Energy Metabolism - methane; Oxidoreductase P42898 4524 1p36.22 human T549-p 178601701 NVKGENItNAPELQP cell cycle regulation 28820331 1 0 0 -KCNQ1 Kv7.1 Channel, potassium; Membrane protein, integral; Membrane protein, multi-pass P51787 3784 11p15.5-p15.4 human K424-sm 1873173302 VVKKKKFkLDKDNGV sumoylation 28743749 1 0 0 A SUMO shifts the half-maximal activation voltage and produces a maximal+34-mV shift. -AKT1 Akt1 EC 2.7.11.1; KINASE; Kinase, protein; Oncoprotein; Protein kinase, AGC; Protein kinase, Ser/Thr (non-receptor) P31749 207 14q32.33 human T211-p 28706901 NSRHPFLtALKYSFQ Pkinase signaling pathway regulation 23768697 0 1 0 PI3K-Akt-eNOS signaling pathway -Ncam1 NCAM1 Cell adhesion; Membrane protein, GPI anchor; Membrane protein, integral; Motility/polarity/chemotaxis P13595 17967 9 A5.3|9 26.83 cM mouse Y734-p 454070 VVMDITCyFLNKCGL cell growth, altered 20605779 2 0 0 -CDC25A CDC25A EC 3.1.3.48; Motility/polarity/chemotaxis; PHOSPHATASE; Protein phosphatase, dual-specificity P30304 993 3p21.31 human S178-p 449126 LFTQRQNsAPARMLS M-inducer_phosp activity, induced; protein degradation; molecular association, regulation; intracellular localization 14-3-3 beta(INDUCES) 12676583; 14559997; 36539837 4 1 0 nuclear-cytoplasmic redistribution -POLM POLM DNA repair, damage; EC 2.7.7.7; Transferase Q9NP87 27434 7p13 human S12-p 469477 RRRARVGsPSGDAAS molecular association, regulation; enzymatic activity, inhibited DNA(DISRUPTS) 23933132 1 20 7 -Sp7 osterix C2H2-type zinc finger protein; DNA-binding; Transcription factor Q8VI67 170574 15|15 F3 mouse K55-ub 31914106 YADLSAPkTMGDAYP protein degradation cell differentiation, inhibited; transcription, induced 25818514 2 0 0 inhibits BMP signaling -MC1R MC1R GPCR, family 1; Membrane protein, integral; Membrane protein, multi-pass; Receptor, GPCR Q01726 4157 16q24.3 human T157-p 8051400 LRYHSIVtLPRARRA 7tm_1 exocytosis, altered 19452503 1 0 1 rescues the retention phenotype of R160W and R162P -IRS4 IRS4 Adaptor/scaffold O14654 8471 Xq22.3 human Y779-p 10781335 DNDSESDyMFMAPGA molecular association, regulation cell cycle regulation; carcinogenesis, induced; cell growth, induced; signaling pathway regulation EBNA1BP2(INDUCES); PIK3R2(INDUCES) 35550247 1 2 3 induces the PI3K-AKT signaling pathway -EP300 p300 ACETYLTRANSFERASE; Acetyltransferase; EC 2.3.1.48; Motility/polarity/chemotaxis; Nuclear receptor co-regulator; Transcription, coactivator/corepressor Q09472 2033 22q13.2 human K1024-ac 458945 TELKTEIkEEEDQPS activity, inhibited transcription, inhibited 15632193 1 1 0 -HSP90AA1 HSP90A Chaperone; Heat shock protein P07900 3320 14q32.31 human T36-p 15410982 LMSLIINtFYSNKEI activity, induced; protein stabilization; molecular association, regulation; enzymatic activity, inhibited CDK4(DISRUPTS); HER2(DISRUPTS); Src(DISRUPTS); CCDC37(DISRUPTS); AHSA1(DISRUPTS) 21419342 1 0 0 increase CFTR stability and GR activity -OXSR1 OSR1 EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, STE; Protein kinase, Ser/Thr (non-receptor) O95747 9943 3p22.2 human T185-p 456503 TRNKVRKtFVGTPCW Pkinase activity, induced; molecular association, regulation; enzymatic activity, induced CAB39(INDUCES) 16083423; 17190791; 18270262; 22032326; 25389294; 29581290 12 6 51 Double knock in lacks its activity; cell volume control dependent on its kinase activity; 2.5-fold increase in Kir2.1 channel activity when cotransfected compared to Kir2.1 alone -KAT2A GCN5 ACETYLTRANSFERASE; Acetyltransferase; EC 2.3.1.48 Q92830 2648 17q21.2 human S372-p 33703201 EEIYGANsPIWESGF acetylation; enzymatic activity, induced 24870244 1 0 0 enhanced acetyltransferase acivity, PGC-1a acetylation, suppresses gluconeogenesis -Braf BRAF EC 2.7.11.1; KINASE; Kinase, protein; Oncoprotein; Protein kinase, Ser/Thr (non-receptor); Protein kinase, TKL F1M9C3 114486 4q22 rat S347-p 450243 GQRDRSSsAPNVHIN molecular association, regulation; enzymatic activity, inhibited cell growth, altered 14-3-3 beta(INDUCES) 17074813 9 27 30 stimulates cell proliferation -SP1 SP1 C2H2-type zinc finger protein; DNA-binding; Transcription factor P08047 6667 12q13.13 human S702-gl 5262509 FMRSDHLsKHIKTHQ zf-C2H2 transcription, induced 18513490 2 1 0 -FOSL1 FRA1 DNA-binding; Transcription factor P15407 8061 11q13.1 human S252-p 478351 ASAHRKSsSSSGDPS molecular association, regulation; protein stabilization carcinogenesis, induced; cell motility, induced; cell growth, induced; cytoskeletal reorganization AXL(INDUCES) 17371847; 21822309; 22286759 3 1 3 -NPM1 NPM1 Nucleolus; Oncoprotein; RNA-binding; Translation P06748 4869 5q35.1 human S70-p 459898 EAMNYEGsPIKVTLA Nucleoplasmin protein stabilization; molecular association, regulation; intracellular localization; phosphorylation cell cycle regulation CDC25C(INDUCES); ARF1(INDUCES) 19933706; 23851489 4 88 30 mutation of S10/S70 to alanine increases CDK1 Y15 phosphorylation; increase ARF protein stabilization; mutation of S10/70 to glutamate decreases Cdc25C S216 phosphorylation -YAP1 YAP1 Oncoprotein; Transcription, coactivator/corepressor P46937 10413 11q22.1 human K76-ub 1883364801 FNAVMNPkTANVPQT protein degradation; ubiquitination carcinogenesis, inhibited; apoptosis, induced; cell motility, inhibited 36280829 1 0 0 -Sntb2 SNTB2 Adaptor/scaffold; Dystrophin complex; Extracellular matrix Q61235 20650 8 D3|8 53.38 cM mouse S75-p 471147 NRGLGPPsPPAPPRG molecular association, regulation; intracellular localization exocytosis, altered PTPRN(DISRUPTS) 20886068 1 75 6 -NPM1 NPM1 Nucleolus; Oncoprotein; RNA-binding; Translation P06748 4869 5q35.1 human K230-ac 6216434 KGQESFKkQEKTPKT molecular association, regulation; intracellular localization transcription, altered H3(INDUCES) 19581289 1 1 4 K212/215/229/230/257/267/292R mutant -Eif4ebp1 4E-BP1 Translation; Translation initiation Q62622 116636 16q12.3 rat T36-p 447497 PPGDYSTtPGGTLFS eIF_4EBP molecular association, regulation; phosphorylation translation, altered EIF4E(DISRUPTS) 10779345; 20736160; 9806882 159 44 88 -PAK1 PAK1 EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, STE; Protein kinase, Ser/Thr (non-receptor) Q13153 5058 11q13.5-q14.1 human T109-p 14150103 QWARLLQtSNITKSE PBD enzymatic activity, inhibited 20400510 1 1 0 in vitro -CASP8 CASP8 Apoptosis; EC 3.4.22.61; Protease Q14790 841 2q33.1 human S387-p 16855100 YLEMDLSsPQTRYIP Peptidase_C14 molecular association, regulation; protein processing; intracellular localization; enzymatic activity, inhibited; protein conformation; phosphorylation cell cycle regulation; apoptosis, altered; carcinogenesis, altered; apoptosis, inhibited PLK1(INDUCES) 20937773; 24342355; 24484936; 26036637; 29233910 5 2 0 mitosis; impairs erlotinib-induced procaspase-8 homodimerization -KLRC1 NKG2A Membrane protein, integral; Receptor, misc. P26715 3821 12p13.2 human Y40-p 455556 ATEQEITyAELNLQK activity, induced; molecular association, regulation; intracellular localization SHP-1(INDUCES) 12165520 1 0 0 -AHR AHR DNA-binding; Transcription factor P35869 196 7p21.1 human S444-p 1874101920 GKDSATTsTLSKDSL protein degradation; ubiquitination autophagy, induced; transcription, induced 34198826 1 0 0 -ADRA1D ADRA1D GPCR, family 1; Membrane protein, integral; Membrane protein, multi-pass; Receptor, GPCR P25100 146 20p13 human T442-p 1346843004 GHHWRAStSGLRQDC receptor internalization, altered signaling pathway regulation 29551601 2 1 0 regulates ERK signaling pathway, induces calcium signaling de-sensitization -IGFBP3 IGFBP3 Cell development/differentiation; Secreted; Secreted, signal peptide P17936 3486 7p12.3 human S140-p 451463 APGNASEsEEDRSAG apoptosis, induced 12210764 3 0 0 -CHEK2 Chk2 EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, CAMK; Protein kinase, Ser/Thr (non-receptor); Tumor suppressor O96017 11200 22q12.1 human Y156-p 1877718908 EVGPKNSyIAYIEDH FHA molecular association, regulation cell cycle regulation; chromatin organization, altered TTK(INDUCES) 35851582 1 1 0 induces HEC1 binding to TTK -EGFR EGFR EC 2.7.10.1; KINASE; Kinase, protein; Membrane protein, integral; Oncoprotein; Protein kinase, TK; Protein kinase, tyrosine (receptor) P00533 1956 7p11.2 human S1039-p 3178884 TPLLSSLsATSNNST receptor internalization, induced; protein degradation endocytosis, induced 24797263; 36184515 3 11 0 -EPS8 EPS8 Adaptor/scaffold Q12929 2059 12p12.3 human Y602-p 450736 LGRADPPyTHTIQKQ cell cycle regulation; cell motility, induced; cell growth, induced; transcription, induced 32641864 2 4 11 -Nfkb1 NFkB-p105 DNA-binding; Transcription factor P25799 18033 3 G3|3 62.82 cM mouse S326-p 22771100 VNITKPAsVFVQLRR RHD_dimer molecular association, regulation; protein conformation transcription, induced; transcription, altered p53(INDUCES) 29873020; 30940658 4 1 0 regulates MALAT1 expression -MPHOSPH8 MPHOSPH8 Cell cycle regulation Q99549 54737 13q12.11 human K439-ac 40709504 RKEPKGLkTLKEIRN protein degradation; ubiquitination 25870236 1 1 0 -Top2b TOP2B Cell development/differentiation; DNA-binding; EC 5.99.1.3; Motility/polarity/chemotaxis; Nucleolus; Topoisomerase Q64511 21974 14|14 A2 mouse S1511-p 459995 VETINSDsDSEFGIP DTHCT transcription, inhibited 36206766 1 83 11 -GRAP2 GADS Adaptor/scaffold O75791 9402 22q13.1 human Y45-p 451894 ELGSQEGyVPKNFID SH3_1 transcription, induced; signaling pathway regulation 33931484 1 5 95 induces TCR signaling -SQSTM1 SQSTM1 Autophagy; Nuclear receptor co-regulator; Ubiquitin conjugating system Q13501 8878 5q35.3 human K13-ub 10840244 VKAYLLGkEDAAREI protein degradation 26746706 1 9 48 -RANBP3 RANBP3 iso3 Adaptor/scaffold Q9H6Z4-3 8498 19p13.3 human S58-p 460735 VKRERTSsLTQFPPS molecular association, regulation; intracellular localization transcription, induced; signaling pathway regulation PPPM1A(INDUCES) 21960005 3 46 126 nuclear export of Smad2/3 inhibited -ELAVL1 HuR RNA-binding Q15717 1994 19p13.2 human S318-p 2246702 GDKILQVsFKTNKSH protein degradation; molecular association, regulation; intracellular localization cell cycle regulation; carcinogenesis, altered; apoptosis, induced; cell motility, altered 14-3-3 theta(INDUCES) RNA(INDUCES); RNA(NOT_REPORTED); RNA(DISRUPTS) 18285462; 20086103; 21310943; 23115237; 23978401; 24492650; 25584704 8 3 0 increases cell migration and proliferation; regulates post-transcriptional HuR functionality -MDC1 MDC1 Cell cycle regulation Q14676 9656 6p21.33 human T404-p 3196400 SMVINSDtDDEEEVS molecular association, regulation cell cycle regulation NBS1(INDUCES) 18678890 1 24 6 MDC1-NBS1 interaction regulates intra-S-phase checkpoint activation -SIT1 SIT Adaptor/scaffold; Membrane protein, integral Q9Y3P8 27240 9p13.3 human Y188-p 448962 ASFPDQAyANSQPAA molecular association, regulation GRB2(INDUCES) 11433379 1 6 194 Y90 is major binding site. -KCNA1 Kv1.1 Channel, potassium; Membrane protein, integral; Membrane protein, multi-pass Q09470 3736 12p13.32 human S446-p 451079 SDLSRRSsSTMSKSE intracellular localization carcinogenesis, induced; transcription, inhibited; signaling pathway regulation 23774215 2 0 0 PKA-Kv1.1 pathway -Nphs1 NPHS1 Cell adhesion; Immunoglobulin superfamily; Membrane protein, integral Q9QZS7 54631 7|7 B1 mouse T1134-p 18507016 EYEESQWtGDRDTRS endocytosis, induced 35451598 2 0 0 -ACP1 ACP1 Cofactor and Vitamin Metabolism - riboflavin; EC 3.1.3.2; EC 3.1.3.48; Motility/polarity/chemotaxis; PHOSPHATASE; Phosphatase (non-protein); Protein phosphatase, tyrosine (non-receptor) Q3SZ94 280977 cow Y133-p 457445 LIIEDPYyGNDADFE LMWPc molecular association, regulation GRB2(INDUCES) 10452533 5 6 81 -Ptk2 FAK EC 2.7.10.2; KINASE; Kinase, protein; Protein kinase, TK; Protein kinase, tyrosine (non-receptor) P34152 14083 15 D3|15 33.94 cM mouse S910-p 447964 KLQPQEIsPPPTANL molecular association, regulation PXN(DISRUPTS) 12692126 20 48 0 -MAP3K20 ZAK EC 2.7.11.25; KINASE; Kinase, protein; Protein kinase, Ser/Thr (non-receptor); Protein kinase, TKL Q9NYL2 51776 2q31.1 human S165-p 455379 HNHTTHMsLVGTFPW PK_Tyr_Ser-Thr enzymatic activity, induced 15342622 1 0 0 -Cttn Cortactin Actin-binding; Cytoskeletal; Motility/polarity/chemotaxis Q60598 13043 7|7 F5 mouse K309-ac 461724 YAKGFGGkYGVQKDR HS1_rep molecular association, regulation; acetylation; intracellular localization DIP2A(INDUCES) 31600191 2 4 20 DIP2A regulates spine morphology and synaptic transmission through acetylation of cortactin; Interaction of DIP2A-cortactin is required for acetylated cortactin; acetylation mimetic cortactin rescues the repetitive behaviors in Dip2a KO mice; acetylation alleviated abnormal PSD95 clustering at the spine head in DIP2A KO neurons -CYBB CYBB EC 1.-.-.-; Membrane protein, integral; Membrane protein, multi-pass; Mitochondrial; Oxidoreductase P04839 1536 Xp21.1-p11.4 human S486-p 241497500 YLTGWDEsQANHFAV NAD_binding_6 enzymatic activity, inhibited 28916473 1 1 0 -BCL10 Bcl-10 Apoptosis; Transcription, coactivator/corepressor; Tumor suppressor O95999 8915 1p22.3 human K31-ub 2134711 LRVYLCEkIIAERHF CARD activity, induced; protein degradation; molecular association, regulation; intracellular localization carcinogenesis, induced; transcription, induced; signaling pathway regulation IKKG(INDUCES) 18287044; 27070702; 27777308 3 1 0 promote NF-kB activation, cIAP1/2-mediated polyubiquitination is necessary for the recruitment of LUBAC to the CBM complex; TCR-mediated NF-?B activation -Kcnd2 Kv4.2 Channel, potassium; Membrane protein, integral; Membrane protein, multi-pass Q63881 rat S552-p 450462 VSGSHRGsVQELSTI intracellular localization 12829703; 18650329 6 8 0 important for Kv4.2 internalization in hippocampal neurons; S552 phosphorylation occurs in response to plasma membrane localization. -NCAPH NCAPH Cell cycle regulation Q15003 23397 2q11.2 human S70-p 3196694 ERLQRRRsRVFDLQF Cnd2 molecular association, regulation; intracellular localization DNA(INDUCES) 28817632 1 10 11 -APH1A APH1A Apoptosis; Endoplasmic reticulum; Membrane protein, integral; Membrane protein, multi-pass Q96BI3 51107 1q21.2 human S251-p 1877641906 LCRRQEDsRVMVYSA molecular association, regulation; enzymatic activity, altered ARRB2(INDUCES) 35858570 1 1 0 -VAV1 VAV1 GEF; GEF, Rac/Rho; Motility/polarity/chemotaxis; Oncoprotein P15498 7409 19p13.3 human Y841-p 464357 ANYVEEDySEYC___ activity, induced; molecular association, regulation carcinogenesis, altered; cell growth, altered Src(INDUCES); PLCG1(INDUCES); SH2-B-beta(INDUCES); Brk(INDUCES) 20457609 1 1 47 -ETV1 ETV1 DNA-binding; Oncoprotein; Transcription factor P50549 2115 7p21.2 human S146-p 3059603 TPSSTPVsPLHHASP ETS_PEA3_N activity, induced transcription, induced 12213813 2 1 0 -BCL2L11 BIM Apoptosis O43521 10018 2q13 human S59-p 454235 GDSCPHGsPQGPLAP molecular association, regulation apoptosis, inhibited beclin 1(INDUCES); LC8(INDUCES) 25526094 7 1 0 anoikis evasion -FLT4 VEGFR3 EC 2.7.10.1; KINASE; Kinase, protein; Membrane protein, integral; Protein kinase, TK; Protein kinase, tyrosine (receptor) P35916 2324 5q35.3 human Y1231-p 4119681 HSLAARYyNWVSFPG molecular association, regulation; enzymatic activity, induced cell motility, induced; cell growth, induced GRB2(INDUCES) 16076871 2 0 1 -SIRT1 SIRT1 Apoptosis; DEACETYLASE; Deacetylase; EC 3.5.1.-; Nuclear receptor co-regulator Q96EB6 23411 10q21.3 human T344-p 25594500 GKLLRNYtQNIDTLE SIR2 molecular association, regulation; acetylation; enzymatic activity, inhibited cell cycle regulation; apoptosis, induced; cytoskeletal reorganization; transcription, induced; signaling pathway regulation DBC-1(DISRUPTS); PLK2(INDUCES) 22728651; 24959379; 30517871 3 2 0 suppress centriole duplication; induces deacetylation of PLK2; regulates p53 acetylation and hence signaling; attenuaties the affinity of SIRT1 for its substrate p53, T344-p promoted apoptosis of HCC cells -Jun Jun Oncoprotein; Transcription factor P05627 16476 4 C5|4 43.34 cM mouse K257-sm 3289001 MESQERIkAERKRMR bZIP_1 molecular association, regulation transcription, inhibited DNA(DISRUPTS) 23396363 2 0 0 -Ptprc CD45 EC 3.1.3.48; Membrane protein, integral; Motility/polarity/chemotaxis; PHOSPHATASE; Receptor protein phosphatase, tyrosine P06800 19264 1 E4|1 60.73 cM mouse S994-p 449974 EPESDESsDDDSDSE Y_phosphatase enzymatic activity, induced 10066810 1 6 0 -Sqstm1 SQSTM1 Autophagy; Nuclear receptor co-regulator; Ubiquitin conjugating system O08623 113894 10q22 rat S348-p 14580829 SSKEVDPsTGELQSL molecular association, regulation KEAP1(INDUCES) 27631370 48 0 1 reduced by LRRK2 overexpression -SDC4 syndecan-4 Cell adhesion; Membrane protein, integral; Motility/polarity/chemotaxis P31431 6385 20q13.12 human S179-p 449863 MKKKDEGsYDLGKKP Syndecan protein stabilization; molecular association, regulation; protein processing; intracellular localization; activity, inhibited; phosphorylation cell cycle regulation; cytoskeletal reorganization; cell adhesion, altered; signaling pathway regulation TIAM1(INDUCES); PKCA(DISRUPTS); syndecan-4(DISRUPTS); PPP3CA(DISRUPTS); Calmodulin(DISRUPTS) Other(DISRUPTS) 12377772; 20229236; 22164265; 29121646; 9748216 11 1 0 Stability of the Rac1-RhoGDI1 complex was increased; binding to lipid increases PKCalpha activation; induces phosphorylation of NFAT, inhibits activity of calcineurin A and NFAT ; S179A mutant abrogates protein shedding ; other = PIP2 binding; decreases PtdIns(4,5)P2 lipid binding -KAT2A GCN5 ACETYLTRANSFERASE; Acetyltransferase; EC 2.3.1.48 Q92830 2648 17q21.2 human T735-p 27421700 KDPDQLYtTLKNLLA acetylation; enzymatic activity, induced transcription, altered 23142079 1 2 0 direct opposition to Sirt1; increases PGC-1a acetylation; Regulates the gluconeogenic transcriptional response of fasted mice -CXCR2 IL8RB GPCR, family 1; Membrane protein, integral; Membrane protein, multi-pass; Receptor, GPCR; Receptor, cytokine P25025 3579 2q35 human S352-p 451048 RPSFVGSsSGHTSTT protein degradation; receptor desensitization, altered; receptor internalization, altered 9079638 1 0 1 -E2f5 E2F5 DNA-binding; Transcription factor Q61502 13559 3|3 A1 mouse T251-p 448010 SQSSTSVtPQKSTMA molecular association, regulation cell cycle regulation; transcription, induced p300(INDUCES) 10783242 1 5 1 -Gphn gephyrin Adaptor/scaffold; EC 2.10.1.1; EC 2.7.7.75 Q03555 64845 6q24 rat S281-p 483463 ASLSTTPsESPRAQA molecular association, regulation neural plasticity gephyrin(DISRUPTS) 23408424; 35307349 5 6 2 regulation of postsynaptic gephyrin cluster size via Calpain degradation -Pard3 PAR3-alpha Adaptor/scaffold; Motility/polarity/chemotaxis Q9Z340 81918 19q12 rat Y1127-p 457508 GHLMDTLyAQVKKPR molecular association, regulation CSK(INDUCES) 35793621 2 25 175 -Ctnnb1 CTNNB1 Actin-binding; Cell adhesion; Motility/polarity/chemotaxis; Nuclear receptor co-regulator; Oncoprotein; Transcription factor Q02248 12387 9 F4|9 72.19 cM mouse Y142-p 449044 AVVNLINyQDDAELA molecular association, regulation cell adhesion, altered CTNNA1(DISRUPTS) 12640114 16 2 0 -Cacna1d CACNA1D Channel, calcium; Membrane protein, integral; Membrane protein, multi-pass P27732 29716 16p16 rat S1534-p 465731 DEFKRIWsEYDPEAK GPHH activity, induced 16763033 1 2 0 required for IGF-1 induced channel potentiation -Dennd1a DENND1A GEF; GEF, Rab; Vesicle Q8K382 227801 2|2 B mouse S536-p 484447 PYRTLKEsDSAEGDE molecular association, regulation 14-3-3 epsilon(INDUCES) 26055712 1 14 1 -ACTB ACTB Cytoskeletal; Motility/polarity/chemotaxis P60709 60 7p22.1 human K326-ac 466094 ALAPSTMkIKIIAPP Actin molecular association, regulation TPM1(DISRUPTS); MYO3B(INDUCES) 32873710 0 5 9 K328 modulates muscle contraction by disrupting inhibitory tropomysin positioning -GYPA GYPA Adaptor/scaffold; Membrane protein, integral P02724 2993 4q31.21 human S38-gl 12726308 TSSSVTKsYISSQTN Glycophorin_A protein conformation 7681597 1 0 0 The structure or conformation of three consecutive Ser/Thr residues may be necessary for its antigenicity. -INCA1 INCA1 Cell cycle regulation Q0VD86 388324 17p13.2 human S191-p 12524603 GRAQLLWsPWSPLDQ molecular association, regulation CCNA1(INDUCES); CCNA2(INDUCES) 15159402 1 0 0 Cyclin A1-CDK2 or Cyclin A2-CDK2 complex -Neurog2 neurogenin 2 Transcription factor P70447 11924 3|3 G2 mouse S234-p 2255100 SCTLSPAsPGSDVDY molecular association, regulation cell growth, altered LDB1(INDUCES) 18400164 2 0 0 important for spinal motor neuron differentiation -Map3k1 MEKK1 EC 2.7.11.25; KINASE; Kinase, protein; Ligase; Protein kinase, STE; Protein kinase, Ser/Thr (non-receptor); UBIQUITIN LIGASE; Ubiquitin conjugating system; Ubiquitin ligase P53349 26401 13 D2.2|13 63.36 cM mouse T280-p 3951974 PFQSGRItPPRRAPS apoptosis, induced 28024901 1 4 1 -H3f3b H3 iso3 DNA-binding P84244 15081 11|11 E2 mouse S10-p 455676 TKQTARKsTGGKAPR Histone activity, induced; molecular association, regulation transcription, induced; transcription, altered; cell growth, altered HP1 alpha(INDUCES) 12578986; 14625384; 15105826; 15994958 241 15 1 -CDCA2 CDCA2 Q69YH5 157313 8p21.2 human S893-p 28698800 SETKVRRsTRLQKDL molecular association, regulation cell cycle regulation H3(DISRUPTS); H2A.1(DISRUPTS) 23746640 1 0 0 -USP10 USP10 DEUBIQUITINASE; EC 3.4.19.12; Protease; RNA-binding; Ubiquitin conjugating system; Ubiquitin-specific protease Q14694 9100 16q24.1 human S76-p 3831744 DTLPRTPsYSISSTL enzymatic activity, induced 26876938 1 3 7 -DKC1 dyskerin EC 5.4.99.-; Isomerase; Lyase; Nucleolus; RNA processing; RNA-binding O60832 1736 Xq28 human K43-sm 31910301 FLIKPESkVAKLDTS protein stabilization 23660516 1 0 0 -RPS6KA3 RSK2 EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, AGC; Protein kinase, Ser/Thr (non-receptor) P51812 6197 Xp22.12 human T115-p 1880515604 KVRDRVRtKMERDIL cell cycle regulation; cell growth, induced 36566564 1 0 0 -CLOCK CLOCK ACETYLTRANSFERASE; Acetyltransferase; DNA-binding; EC 2.3.1.48; Transcription factor O15516 9575 4q12 human T461-p 469131 KIPTDTStPPRQHLP intracellular localization transcription, induced 24235147 1 3 2 regulate nuclear/cytoplasmic localization, Cdk5-mediated increased CLOCK transcription -CNR2 CNR2 GPCR, family 1; Membrane protein, integral; Membrane protein, multi-pass; Receptor, GPCR P34972 1269 1p36.11 human S352-p 450818 KITPWPDsRDLDLSD protein degradation; ubiquitination; receptor desensitization, altered 10400664; 36448459 2 1 0 -Pdc phosducin G protein regulator, misc. P20942 25343 13q21 rat S54-p 454888 KEILRQMsSPQSRDD Phosducin protein stabilization; molecular association, regulation; protein conformation G-gamma 2(DISRUPTS); 14-3-3 zeta(INDUCES); G-beta 1(DISRUPTS) 11331285; 23199924; 25971962; 28402877 5 3 1 slows down the dephosphorylation of pS54 and pS73 -DNER DNER Membrane protein, integral; Receptor, misc. Q8NFT8 92737 2q36.3 human Y718-p 473324 YDVSPIAyEDYSPDD DNER_C intracellular localization 18474614 1 1 4 -Tnni3 TNNI3 Actin-binding; Motility/polarity/chemotaxis; Motor P48787 21954 7 A1|7 2.61 cM mouse S23-p 448423 PAPVRRRsSANYRAY Troponin-I_N activity, induced; activity, inhibited; protein conformation; phosphorylation cytoskeletal reorganization 12923217; 15507454; 15774859; 17010989; 17615373; 20083117; 22527640; 8530519 68 11 11 TNNI3 transgenic and gene transfer of S22/23D showed faster relaxation times. ; ROCK II induced desensitization to Ca++ and depression in maximal tension. -Arhgef15 ephexin-5 GEF; GEF, Rac/Rho Q5FWH6 442801 11|11 B3 mouse Y361-p 17790901 PLQDEPLyQTYRAAV protein degradation; ubiquitination 21029865 1 0 0 -BAG3 BAG3 Apoptosis; Chaperone O95817 9531 10q26.11 human S291-p 467532 STPLHSPsPIRVHTV protein degradation neural plasticity 31955914 2 40 27 -LDHA LDH-A Amino Acid Metabolism - cysteine and methionine; Apoptosis; Carbohydrate Metabolism - glycolysis and gluconeogenesis; Carbohydrate Metabolism - propanoate; Carbohydrate Metabolism - pyruvate; EC 1.1.1.27; Oxidoreductase P00338 3939 11p15.1 human K5-ac 461532 ___MATLkDQLIYNL protein degradation; molecular association, regulation; enzymatic activity, inhibited carcinogenesis, inhibited; autophagy, induced; cell growth, inhibited; cell motility, inhibited HSC70(INDUCES) 23523103 1 5 78 -GRK2 GRK2 EC 2.7.11.15; KINASE; Kinase, protein; Protein kinase, AGC; Protein kinase, Ser/Thr (non-receptor) P25098 156 11q13.2 human S685-p 447726 VPLVQRGsANGL___ molecular association, regulation G-alpha(q)(INDUCES) 16885398 3 11 1 -Kcnk10 TREK-2 Channel, potassium; Membrane protein, integral; Membrane protein, multi-pass Q9JIS4 65272 6q32 rat S359-p 465530 RETRRRLsVEIHDKL activity, inhibited 16672694; 17540699 2 1 0 relative channel activity reduced in S326D and S359D mutants; shift of gating modes; inhibition mediated by ACh -INCENP INCENP Cell cycle regulation; EC 2.7.11.1 Q9NQS7 3619 11q12.3 human T892-p 450466 KPRYHKRtSSAVWNS activity, induced; protein stabilization; molecular association, regulation; enzymatic activity, induced INCENP(INDUCES) 12925766; 27332895 2 6 3 -SCRIB Scribble Cell adhesion; Motility/polarity/chemotaxis Q14160 23513 8q24.3 human S1378-p 470678 EGPPKRVsLVGADDL intracellular localization cell motility, induced; cell adhesion, induced 33583073 2 50 82 -Mertk Mer EC 2.7.10.1; KINASE; Kinase, protein; Membrane protein, integral; Oncoprotein; Protein kinase, TK; Protein kinase, tyrosine (receptor) Q60805 17289 2|2 F1 mouse Y867-p 1319200 QDKESIIyINTQLLE phosphorylation exocytosis, altered 18039660 1 0 0 regulates phagocytosis and Y861 phosphorylation of FAK, and Akt activation -Cdkn1b p27Kip1 Cell cycle regulation; Inhibitor; Oncoprotein; Protein kinase, regulatory subunit P46414 12576 6 G1|6 65.77 cM mouse Y88-p 456818 RGSLPEFyYRPPRPP molecular association, regulation CK2A1(DISRUPTS) 28295363 14 0 0 -NR1I3 NR1I3 DNA-binding; Nuclear receptor Q14994 9970 1q23.3 human T38-p 11281700 CKGFFRRtVSKSIGP zf-C4 molecular association, regulation; intracellular localization; protein conformation; activity, inhibited transcription, induced; transcription, inhibited; signaling pathway regulation ERK2(INDUCES); RACK1(INDUCES); ERK1(INDUCES); NR1I3(INDUCES); RXRA(DISRUPTS) DNA(DISRUPTS) 19858220; 21873423; 23652203; 24252946; 28265001; 29133527 6 0 0 homodimerization -PTEN PTEN Carbohydrate Metabolism - inositol phosphate; EC 3.1.3.16; EC 3.1.3.48; EC 3.1.3.67; Motility/polarity/chemotaxis; Nuclear receptor co-regulator; PHOSPHATASE; Phosphatase, lipid; Tumor suppressor P60484 5728 10q23.31 human Y336-p 7596704 NKDKANRyFSPNFKV PTEN_C2 protein stabilization; molecular association, regulation NEDD4 iso4(DISRUPTS) 19345329 2 0 0 -CD6 CD6 Cell surface; Membrane protein, integral P30203 923 11q12.2 human S505-p 15402653 ALTTFYNsQRHRVTD phosphorylation signaling pathway regulation 23711376 1 0 0 ERK1/2 phosphorylation, MAPK pathway activation -BRAF BRAF EC 2.7.11.1; KINASE; Kinase, protein; Oncoprotein; Protein kinase, Ser/Thr (non-receptor); Protein kinase, TKL P15056 673 7q34 human S750-p 2192591 FSLYACAsPKTPIQA molecular association, regulation cell growth, altered RAF1(DISRUPTS) 19933846 2 12 3 -Foxa2 FOXA2 DNA-binding; Transcription factor P32182 rat K6-sm 27852600 __MLGAVkMEGHEPS protein stabilization transcription, induced 23118920 1 0 0 -RGS7 RGS7 GAP; GAP, RGS P49802 6000 1q43|1q23.1 human S434-p 455540 YKLMKSDsYPRFIRS RGS molecular association, regulation 14-3-3 beta(DISRUPTS) 12077120 1 0 0 -CEP131 CEP131 Calcium-binding Q9UPN4 22994 17q25.3 human T205-p 1868722300 PLKSSNQtAPSLNNI molecular association, regulation; intracellular localization carcinogenesis, induced; cytoskeletal reorganization; signaling pathway regulation STIL(INDUCES) 31358734 1 1 0 interaction with STIL promotes STIL relocation to the centrioles -DVL3 DVL3 Motility/polarity/chemotaxis Q92997 1857 3q27.1 human S636-p 34668132 ASEHSHRsHHSLASS Dsh_C intracellular localization 24993822 1 1 0 -DAZL DAZL Translation Q92904 1618 3p24.3 human S65-p 31908003 SFFARYGsVKEVKII RRM_1 molecular association, regulation translation, inhibited PABP 1(DISRUPTS) 27280388 1 1 0 negative regulator of male meiosis -POU5F1 Oct4 DNA-binding; Transcription factor Q01860 5460 6p21.33 human K156-ub 57951800 FAKLLKQkRITLGYT Pou protein stabilization; molecular association, regulation transcription, induced SOX2(INDUCES) 27369080 1 1 0 -SMURF1 SMURF1 EC 6.3.2.-; EC 6.3.2.19; Ligase; UBIQUITIN LIGASE; Ubiquitin conjugating system; Ubiquitin ligase Q9HCE7 57154 7q22.1 human T332-p 18156100 VDHNNRTtQFTDPRL WW protein stabilization 28581524 2 0 0 -Klf10 KLF10 C2H2-type zinc finger protein; DNA-binding; Transcription factor O89091 21847 15|15 B3.1 mouse T188-p 25743268 DNSFRRRtHGNVEAT protein stabilization; molecular association, regulation transcription, inhibited DNA(INDUCES) 34869587 1 0 1 -SUPT5H SPT5 RNA-binding; Transcription, coactivator/corepressor O00267 6829 19q13.2 human S773-p 15415344 GRTPMYGsQTPMYGS transcription, induced 10757782 1 1 6 -SDC1 syndecan-1 Extracellular matrix; Membrane protein, integral; Motility/polarity/chemotaxis P18827 6382 2p24.1 human Y309-p 455075 PTKQEEFyA______ molecular association, regulation cytoskeletal reorganization; cell adhesion, altered syntenin(DISRUPTS) 19228696 2 9 162 required for LG4/5-induced microspikes -CACNA1B CACNA1B Channel, calcium; Membrane protein, integral; Membrane protein, multi-pass Q05152 100008979 rabbit S447-p 459048 TGLCAPGsPFARASL activity, induced 16406008 1 1 4 -Creb1 CREB DNA-binding; Transcription factor Q01147 12912 1 C2|1 32.74 cM mouse Y120-p 15409156 ILSRRPSyRKILNDL pKID phosphorylation neural plasticity; transcription, inhibited 32776935; 32878981 4 0 4 increase 119 phosphorylation by Y120F mutant -PYGM PYGM Carbohydrate Metabolism - starch and sucrose; EC 2.4.1.1; Endoplasmic reticulum; Phosphorylase; Transferase P11217 5837 11q13.1 human S15-p 449838 QEKRKQIsVRGLAGV protein conformation; enzymatic activity, induced 1150650 5 7 1 14 residue phosphopeptide with phosphorylated S14, PYGM becomes activated in the absence of AMP and associates to a tetramer. -WEE1 Wee1 EC 2.7.10.2; KINASE; Kinase, protein; Protein kinase, Other; Protein kinase, Ser/Thr (non-receptor); Protein kinase, tyrosine (non-receptor) P30291 7465 11p15.4 human T239-p 11311200 QVNINPFtPDSLLLH enzymatic activity, inhibited; phosphorylation cell cycle regulation 19858290; 25744022 2 0 0 Inhibits CDK1 phosphorylation and prevents SAC slippage -ATM ATM DNA repair, damage; EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, Ser/Thr (non-receptor); Protein kinase, atypical; Tumor suppressor Q13315 472 11q22.3 human S1981-p 448797 SLAFEEGsQSTTISS activity, induced; protein stabilization; molecular association, regulation; enzymatic activity, inhibited; intracellular localization; phosphorylation; enzymatic activity, induced cell cycle regulation; carcinogenesis, induced; apoptosis, altered; carcinogenesis, altered; carcinogenesis, inhibited; apoptosis, induced; transcription, altered; signaling pathway regulation; DNA repair, induced; autophagy, induced; cell growth, induced; chromatin organization, altered; apoptosis, inhibited; DNA repair, altered PKM(INDUCES); p53(INDUCES); H2AX(INDUCES); CDCA2(DISRUPTS); BUB1B(INDUCES); ATM(INDUCES); MDC1(INDUCES); NBS1(INDUCES); NKX3-1(INDUCES) DNA(INDUCES) 12556884; 14695167; 15048089; 15173573; 15269203; 15964794; 16141325; 16478990; 17486112; 17940005; 18449195; 18560558; 18571408; 18987440; 19071136; 20026654; 20188555; 20372057; 20637859; 22099307; 23365634; 23708966; 23890999; 24876101; 25299772; 25355892; 25775545; 26586426; 27810895; 31980741; 32075772; 32203529; 33512436; 33857133; 34482636; 34545188; 34604061; 34676045; 35045984; 35353542; 35513056; 35798878; 36065181; 36273494; 36692427 214 24 4 -CTNND1 CTNND1 Actin-binding; Adaptor/scaffold; Cell adhesion; G protein regulator, misc.; Motility/polarity/chemotaxis O60716 1500 11q12.1 human S269-p 470326 QVRVGGSsVDLHRFH activity, induced; protein stabilization; molecular association, regulation endocytosis, induced; transcription, induced CDH2(DISRUPTS); LRP5(DISRUPTS); LRP6(DISRUPTS) 24412065 2 54 8 GSK3, Axin, Dvl-2 internalization induced, stabilization and transcriptional activity of CTNNB1 induced -AQP4 AQP4 iso4 Channel, misc.; Membrane protein, integral; Membrane protein, multi-pass; Transporter; Transporter, aquaporin family A0A5F9ZHR4 361 18q11.2 human S335-p 1877492101 RTESRQDsLELSSDF intracellular localization 35625560 1 0 0 -NFKBIA IkB-alpha DNA-binding; Inhibitor P25963 4792 14q13.2 human S63-p 1873119300 PQEVPRGsEPWKQQL phosphorylation carcinogenesis, induced; cell growth, induced; apoptosis, inhibited; transcription, induced 34030642 1 1 0 induce p65 trancsription activity; inhibits phosphorylation of RIP3 and MLKL -CREB1 CREB DNA-binding; Transcription factor P16220 1385 2q33.3 human K122-ac 459099 SRRPSYRkILNDLSS pKID molecular association, regulation transcription, induced p300(INDUCES); CBP(INDUCES) 25404345 4 0 0 -ARHGDIA RhoGDI alpha Apoptosis; Cell adhesion; Cell development/differentiation; G protein regulator, misc.; Motility/polarity/chemotaxis P52565 396 17q25.3 human Y156-p 469606 YGPRAEEyEFLTPVE Rho_GDI molecular association, regulation; enzymatic activity, inhibited; intracellular localization carcinogenesis, induced; cell motility, induced RHOA(DISRUPTS); RAC1(DISRUPTS); CDC42 iso1(DISRUPTS) 16943322; 20028975; 32003021; 34532864 4 2 22 -Prkcd PKCD EC 2.7.11.13; KINASE; Kinase, protein; Nuclear receptor co-regulator; Protein kinase, AGC; Protein kinase, Ser/Thr (non-receptor); Protein kinase, tyrosine (non-receptor); Tumor suppressor P09215 170538 16p16 rat T141-p 1028305 EEEAMFPtMNRRGAI phosphorylation; enzymatic activity, induced 26546672 2 9 1 downregulates phosphorylation of S357 -Zbtb17 ZBTB17 C2H2-type zinc finger protein; DNA-binding; Transcription factor Q60821 22642 4|4 D3 mouse S178-p 5881622 GQAESASsGAEQTEK molecular association, regulation DNA(INDUCES) 23525087 1 1 1 inhibits recruitment of HDAC1 to Cebpd promoter, suppression of inflammation -Vim Vimentin Cytoskeletal; Motility/polarity/chemotaxis P20152 22352 2 A1|2 10.04 cM mouse S66-p 451765 GAYVTRSsAVRLRSS Filament_head cytoskeletal reorganization 12458200 5 11 20 -SQSTM1 SQSTM1 Autophagy; Nuclear receptor co-regulator; Ubiquitin conjugating system Q13501 8878 5q35.3 human K91-ub 15398061 TMAMSYVkDDIFRIY PB1 autophagy, induced 27880896 1 0 32 antibacterial autophagy -Pak1 PAK1 EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, STE; Protein kinase, Ser/Thr (non-receptor) P35465 29431 1q32 rat T211-p 448176 VIEPLPVtPTRDVAT intracellular localization cytoskeletal reorganization 12176334 17 27 19 during mitosis -MYC Myc DNA-binding; Nucleolus; Oncoprotein; Transcription factor P01106 4609 8q24.21 human S77-p 448586 LLPTPPLsPSRRSGL Myc_N O-GlcNAc glycosylation; protein degradation; molecular association, regulation; protein stabilization; phosphorylation; activity, induced; ubiquitination; intracellular localization cell cycle regulation; carcinogenesis, induced; apoptosis, altered; apoptosis, induced; transcription, induced; transcription, altered; cell growth, induced; chromatin organization, altered; apoptosis, inhibited; cell growth, altered FBXW7(INDUCES); SH2BP1(INDUCES); OTUD6A(INDUCES); CDC73(INDUCES); AurA(INDUCES); PIN1(INDUCES); RNF4(INDUCES); axin 1(INDUCES); PPP2R5A(NOT_REPORTED); CIP2A(INDUCES) DNA(INDUCES) 10551811; 11018017; 11243879; 11904304; 15103331; 15150404; 16483932; 16537924; 17634226; 18408012; 19028839; 19131971; 20140016; 21808024; 22025562; 23318434; 23716601; 25006129; 25438055; 25893300; 25944903; 26235622; 26687678; 27002159; 27213815; 27239040; 27653698; 33552953; 33627622; 33854232; 33928666; 34192548; 34289988; 34758313; 35039060; 35089787; 35217790; 36012403; 37408910; 37656618; 8386367 86 38 33 -MET Met EC 2.7.10.1; KINASE; Kinase, protein; Membrane protein, integral; Oncoprotein; Protein kinase, TK; Protein kinase, tyrosine (receptor) P08581 4233 7q31.2 human Y1234-p 448470 RDMYDKEyYSVHNKT PK_Tyr_Ser-Thr activity, induced; protein conformation; phosphorylation; enzymatic activity, induced carcinogenesis, induced; cell motility, induced; cell motility, altered; apoptosis, inhibited; signaling pathway regulation; cell growth, altered GRB2(INDUCES); PTP1B(INDUCES); PTPN2(INDUCES) 10490849; 12746450; 14559966; 18819921; 21247903; 21918175; 22081023; 24634221; 27147579; 7961992; 8302603 57 36 740 -F2RL1 F2RL1 GPCR, family 1; Membrane protein, integral; Membrane protein, multi-pass; Receptor, GPCR P55085 2150 5q13.3 human S390-p 22350016 SSSYSSSsTTVKTSY receptor desensitization, induced; molecular association, regulation; phosphorylation signaling pathway regulation ARRB1(INDUCES); ARRB2(INDUCES) 33073187 1 1 0 inhibits ERK phosphorylation and signaling; regulates calcium signaling -Becn1 beclin 1 Adaptor/scaffold; Autophagy; Membrane protein, peripheral O88597 56208 11|11 D mouse S29-p 7446159 QPLKLDTsFKILDRV protein degradation; intracellular localization endocytosis, induced; cytoskeletal reorganization; signaling pathway regulation 33775979 5 6 0 PGK1-beclin1 pathway regulation; regulates AcLDL localization and degradation -Ctnnd2 CTNND2 Actin-binding; Motility/polarity/chemotaxis O35927 18163 15|15 B2 mouse Y1176-p 461085 QEPSRKDyETYQPFP protein stabilization; molecular association, regulation cell cycle regulation; cell motility, altered GSK3B(DISRUPTS) 18515860; 24412473 1 2 2 -Panx1 PANX1 Cell adhesion; Membrane protein, integral; Membrane protein, multi-pass P60570 315435 8q12 rat Y308-p 54421200 KTDVLKVyEILPTFD activity, induced apoptosis, induced 26854804 3 0 0 NMDAR-Src-Panx1 signaling -FOXO3 FOXO3A Autophagy; DNA-binding; Oncoprotein; Transcription factor O43524 2309 6q21 human S555-p 20799903 RALSNSVsNMGLSES phosphorylation transcription, induced 17711846 2 1 0 induces phosphorylation of other sites -HMGN1 HMGN1 DNA-binding; Nuclear receptor co-regulator P05114 3150 21q22.2 human S25-p 454112 KRRSARLsAKPPAKV HMG14_17 molecular association, regulation; intracellular localization transcription, altered 14-3-3 zeta(INDUCES); SRF(DISRUPTS) DNA(DISRUPTS) 10739259; 12215538; 17938209 5 12 0 -NCF4 p40phox Oxidoreductase Q15080 4689 22q12.3 human T154-p 448266 LRRLRPRtRKVKSVS enzymatic activity, induced 34264265 5 0 0 -Sox4 SOX4 DNA-binding; Transcription factor Q06831 20677 13 A3.1|13 12.87 cM mouse S316-p 41454646 GRSSAASsPAASRSP protein degradation cell differentiation, induced 34431536 1 3 0 -SOD2 SOD2 EC 1.15.1.1; Mitochondrial; Oxidoreductase P04179 6648 6q25.3 human S106-p 7577901 SIFWTNLsPNGGGEP Sod_Fe_N protein stabilization; enzymatic activity, induced apoptosis, inhibited 23243068; 25578653 4 1 0 mitochondrial apoptosis -RPL11 RPL11 Motility/polarity/chemotaxis; Nucleolus; Ribosomal; Translation P62913 6135 1p36.11 human K85-ne 12067603 KAEEILEkGLKVREY Ribosomal_L5_C protein stabilization; intracellular localization 19713960 1 0 0 -NBN NBS1 Cell cycle regulation; DNA repair, damage O60934 4683 8q21.3 human K208-ac 487507 DEPSIGSkNVDLSGR phosphorylation cell cycle regulation; apoptosis, induced; DNA repair, inhibited 17612497; 28869605 3 1 0 -Usp8 USP8 DEUBIQUITINASE; EC 3.4.19.12; Protease; Ubiquitin conjugating system; Ubiquitin-specific protease Q80U87 84092 2|2 F1 mouse S680-p 454338 SKLKRSYsSPDITQA molecular association, regulation 14-3-3 beta(INDUCES); 14-3-3 epsilon(INDUCES) 16944949; 23333852 4 71 26 -CYCS CYCS Apoptosis; Mitochondrial; Oxidoreductase; PHOSPHATASE; Protein phosphatase, Ser/Thr (non-receptor) P62894 510767 cow Y49-p 473243 GQAPGFSyTDANKNK Cytochrom_C activity, inhibited signaling pathway regulation 18471988; 20586425; 21771582 4 4 4 inhibits mitochondrial prespiration; regualtion of electron transport chain; Y48E mutation decreases CYCS redox potential -Oprm1 MOR-1 GPCR, family 1; Membrane protein, integral; Membrane protein, multi-pass; Receptor, GPCR P33535 25601 1q11 rat S355-p 3063302 REFCIPTsSTIEQQN receptor desensitization, altered; phosphorylation 12123746 1 0 0 -CHMP7 CHMP7 Q8WUX9 91782 8p21.3 human S3-p 54367850 _____MWsPEREAEA molecular association, regulation cell cycle regulation CHMP7(DISRUPTS); LEMD2(DISRUPTS) 34286694 1 1 0 -Bach1 BACH1 DNA-binding; Transcription factor P97302 12013 16|16 C3.3 mouse Y486-p 11498503 LEIGNYDyVSEPQQE molecular association, regulation; intracellular localization transcription, altered Exportin-1(INDUCES) 19897490 1 0 0 -SIRT1 SIRT1 Apoptosis; DEACETYLASE; Deacetylase; EC 3.5.1.-; Nuclear receptor co-regulator Q96EB6 23411 10q21.3 human S669-p 1874020212 EDDVLSSsSCGSNSD molecular association, regulation; acetylation; protein conformation; enzymatic activity, induced transcription, induced p53(INDUCES); DBC1(DISRUPTS) 34216621 1 1 0 inhibits PGC-1a deacetylation -Map2 MAP2 iso3 Cytoskeletal; Motility/polarity/chemotaxis P15146-3 25595 9q32 rat K401-ac 62495509 NVKIDSQkLNFREHA cytoskeletal reorganization 28002468 1 1 0 -LAT2 LAB Adaptor/scaffold; Membrane protein, integral Q9GZY6 7462 7q11.23 human Y136-p 450963 EDDDANSyENVLICK LAT2 molecular association, regulation cell differentiation, altered GRB2(INDUCES) 14722116 3 10 169 -OSMR OSMR Membrane protein, integral; Receptor, cytokine Q99650 9180 5p13.1 human Y837-p 462479 TELTKPNyLYLLPTE phosphorylation 18430728 2 5 19 important for STAT5B activation -MBP MBP Cytoskeletal P02687 618684 cow R106-m1 475947 PPSQGKGrGLSLSRF Myelin_MBP protein conformation 5128665 3 2 8 -CDKN1A p21Cip1 Cell cycle regulation; Inhibitor P38936 1026 6p21.2 human K141-ac 12615905 PGDSQGRkRRQTSMT protein stabilization; molecular association, regulation cell cycle regulation; carcinogenesis, inhibited; cell growth, inhibited C8A(DISRUPTS) 20154723 1 0 0 -WASF2 WAVE2 Actin-binding; Motility/polarity/chemotaxis Q9Y6W5 10163 1p36.11 human S488-p 6377641 YSDSEDDsSEFDEDD activity, inhibited cytoskeletal reorganization 19012317 1 0 1 -RHOA RHOA G protein; G protein, monomeric; G protein, monomeric, Rho; Motility/polarity/chemotaxis; Oncoprotein P61586 387 3p21.31 human Y66-p 475231 DTAGQEDyDRLRPLS Ras molecular association, regulation; activity, inhibited cytoskeletal reorganization; signaling pathway regulation PKN1(DISRUPTS); PKN2(DISRUPTS); Diaphanous-1(DISRUPTS); RTKN(DISRUPTS); ROCK2(DISRUPTS); DAAM1(DISRUPTS); ROCK1(DISRUPTS) 23027962 1 3 12 phosphorylation of this site inhibits binding of RhoA to cellular effectors; phosphorylation of this site inhibits F-actin formation -MTOR mTOR Autophagy; EC 2.7.11.1; KINASE; Kinase, protein; Motility/polarity/chemotaxis; Protein kinase, Ser/Thr (non-receptor); Protein kinase, atypical P42345 2475 1p36.22 human T631-p 59070502 RTCSRLLtPSIHLIS protein degradation; ubiquitination 27746162 1 0 0 -Pdgfra PDGFRA EC 2.7.10.1; KINASE; Kinase, protein; Membrane protein, integral; Oncoprotein; Protein kinase, TK; Protein kinase, tyrosine (receptor) P20786 25267 14p11 rat Y848-p 448441 DIMHDSNyVSKGSTF PK_Tyr_Ser-Thr cell motility, induced; cell growth, induced 34858182 8 9 59 -BECN1 beclin 1 Adaptor/scaffold; Autophagy; Membrane protein, peripheral Q14457 8678 17q21.31 human S15-p 25268704 NNSTMQVsFVCQRCS intracellular localization autophagy, induced 26118643; 35443161; 36719945 11 1 0 induces mitophagy -YWHAG 14-3-3 gamma Adaptor/scaffold P61981 7532 7q11.23 human S59-p 3892745 VVGARRSsWRVISSI 14-3-3 molecular association, regulation; intracellular localization TNRC6A(INDUCES) 21118956 2 0 8 localizes to P-bodies -Hnrnpk hnRNP K RNA splicing; RNA-binding; Spliceosome P61979 15387 13|13 B1 mouse S302-p 457408 GRGGRGGsRARNLPL molecular association, regulation translation, induced RNA(INDUCES) 17581920 4 0 0 -Cdk5rap2 CDK5RAP2 Cytoskeletal Q8K389 214444 4|4 C2 mouse S608-p 41285495 KALQEQLsEIRSREE cell cycle regulation 29282278 1 1 0 PLK1-dependent CDK5RAP2 phosphorylation at S608 leads to increased chromosome instability through the formation of lagging chromosomes and formation of micronuclei. -YAF2 YAF2 Transcription, coactivator/corepressor Q8IY57 10138 12q12 human S167-p 3205731 RGMSRSSsPRGEASS protein stabilization carcinogenesis, induced; apoptosis, inhibited 33784512 2 24 2 induces FANK1 stabilization -ASL ASL Amino Acid Metabolism - alanine, aspartate and glutamate; Amino Acid Metabolism - arginine and proline; EC 4.3.2.1; Endoplasmic reticulum; Lyase; Mitochondrial P04424 435 7q11.21 human K288-ac 27614500 SSLMPQKkNPDSLEL Lyase_1 enzymatic activity, inhibited 20167786 0 2 0 -Sh3gl2 endophilin A1 Adaptor/scaffold; Membrane protein, peripheral; Vesicle O35179 116743 rat S75-p 33402207 LSMINTMsKIRGQEK BAR endocytosis, altered 24778241 1 0 0 Vesicle and membrane formation. Phosphomimetic modification at S75 inhibits stable tubulation by shifting the insert region to shallower depths within the lipid bilayer. -UBA52-RPS27A-UBB-UBC ubiquitin Ubiquitin-like modifier P62988 2p16 human K6-ac 459084 __MQIFVkTLTGKTI ubiquitin protein degradation; molecular association, regulation; ubiquitination UBE2V1(INDUCES) 15790562; 25527407 5 7 6 inhibits polyubiquitin chain elongation -NHERF4 PDZD3 Cell adhesion Q86UT5 79849 11q23.3 human S395-p 25546601 LGHEETVsRIQGQGS PDZ molecular association, regulation SLC26A3(INDUCES) 22627094 1 0 0 -BBC3 PUMA Apoptosis; Mitochondrial Q9BXH1 27113 19q13.32 human S10-p 18610000 RARQEGSsPEPVEGL PUMA protein degradation; molecular association, regulation; ubiquitination carcinogenesis, induced; cell growth, induced; apoptosis, inhibited FBXL20(INDUCES) 21364664; 21997190; 34587475 3 11 0 -Slc1a2 GLT1 Membrane protein, integral; Membrane protein, multi-pass; Transporter; Transporter, SLC family P31596 29482 3q32 rat Y403-p 3064900 NMDGTALyEAVAAIF SDF activity, induced 12384259 1 0 0 Y403H mutant sensitive to volatile anesthetics -Hspa8 HSC70 Chaperone; Heat shock protein; Nucleolus; RNA-binding P63017 15481 9 A5.1|9 21.55 cM mouse S85-p 31857927 FDDAVVQsDMKHWPF HSP70 molecular association, regulation autophagy, induced PKM iso2(INDUCES); APP(INDUCES); HK2(INDUCES) 34291435 1 7 0 -Gli1 GLI1 C2H2-type zinc finger protein; Oncoprotein; Transcription factor P47806 14632 10 D3|10 74.5 cM mouse S481-p 1412327901 GGSTEDLsSLDEGPC molecular association, regulation; intracellular localization cell cycle regulation; transcription, inhibited; signaling pathway regulation SUFU(INDUCES) 30578313 1 1 0 Hedgehog (Hh) signaling reduced by phosphorylation -DDB2 DDB2 DNA repair, damage Q92466 1643 11p11.2 human K77-ub 1876931105 VRTLHQHkLGRASWP DNA repair, induced 32789493 1 1 0 SIRT6 as a critical factor in the regulation of the process of UV-induced DNA damage repair -Cdc7 CDC7 EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, Other; Protein kinase, Ser/Thr (non-receptor) Q9Z0H0 12545 5|5 E5 mouse T367-p 2864203 QVAPRAGtPGFRAPE Pkinase enzymatic activity, induced cell growth, induced; cell differentiation, induced; transcription, induced; cytoskeletal reorganization 22223649 3 1 12 -CENPQ CENPQ Q7L2Z9 55166 6p12.3 human T135-p 40245505 PKKMEDLtNVSSLLN CENP-Q molecular association, regulation; intracellular localization DNA(DISRUPTS) 25670858 1 1 0 CENPQ phosphorylation promotes the delocalization of the PBIP1-CENPQ complex from kinetochores -Cnp CNP Cell development/differentiation; EC 3.1.4.37; Phosphodiesterase P13233 25275 10q31 rat K150-ac 1881330702 QVVLVEPkTAWRLDC enzymatic activity, inhibited; protein conformation 34330062 1 1 0 -H3c1 H3 DNA-binding P68433 360198 13|13 A3.1 mouse K36-m2 1458610 APATGGVkKPHRYRP Histone transcription, inhibited 20561915 44 18 7 -ZBTB25 ZBTB25 C2H2-type zinc finger protein P24278 7597 14q23.3 human K204-sm 1873596000 QKPPVSIkQERCDPE molecular association, regulation transcription, induced RNA(INDUCES) 28768860 1 0 0 IAV RNA binding and promotion of viral transcription and/or replication -Pou5f1 Oct4 DNA-binding; Transcription factor P20263 18999 17 B1|17 18.69 cM mouse S347-p 25236701 VPVTALGsPMHSN__ protein degradation; ubiquitination cell differentiation, induced; transcription, inhibited 29153991 2 3 0 improve the reprogramming efficiency of SKH-1 MEFs -Nfkbib IkB-beta Inhibitor Q60778 18036 7|7 B1 mouse S313-p 452013 DKLSPCSsSGSDSDS apoptosis, induced; autophagy, inhibited 27508931 4 0 0 Hypo-phosphorylated S313 is beneficial to the heart in sepsis through inhibition of apoptosis and enhancement of autophagy in mutated I?B? transgenic mice. -Nedd4l NEDD4L EC 6.3.2.-; EC 6.3.2.19; Ligase; UBIQUITIN LIGASE; Ubiquitin conjugating system; Ubiquitin ligase Q8CFI0 83814 18|18 E1 mouse T396-p 453439 TRRARSStVTGGEEP molecular association, regulation; intracellular localization 14-3-3 epsilon(INDUCES) 21900244 5 3 15 -Slc23a2 SLC23A2 Membrane protein, integral; Membrane protein, multi-pass; Transporter; Transporter, SLC family Q9EPR4 54338 2|2 F2 mouse S640-p 483980 KSENSRSsDKDSQAT intracellular localization cell differentiation, altered 17585336 1 0 0 Phosphorylation is required for SLC3A2 localization in plasma membrane, and ascorbic acid uptake. -HMGB1 HMGB1 DNA repair, damage; Nuclear receptor co-regulator P09429 3146 13q12.3 human S181-p 20506700 GVVKAEKsKKKKEEE intracellular localization 22750245 3 0 0 -DDR1 DDR1 EC 2.7.10.1; KINASE; Kinase, protein; Membrane protein, integral; Protein kinase, TK; Protein kinase, tyrosine (receptor) Q08345 780 6p21.33 human Y513-p 457956 LLLSNPAyRLLLATY activity, induced; molecular association, regulation SHC1(INDUCES) 24509848; 27605668; 9659899 3 9 335 -Map3k11 MLK3 EC 2.7.11.25; KINASE; Kinase, protein; Protein kinase, Ser/Thr (non-receptor); Protein kinase, TKL Q80XI6 26403 19 A|19 4.34 cM mouse S282-p 448262 WHKTTQMsAAGTYAW PK_Tyr_Ser-Thr enzymatic activity, induced 34324442 8 0 0 -NFATC3 NFAT4 DNA-binding; Transcription factor Q12968 4775 16q22.1 human S207-p 11507602 AARFTLGsPLTSPGG intracellular localization 9630228 1 2 1 cytoplasmic localization (inhibition of nuclear localization) -GIT2 GIT2 GAP; GAP, ARF; Motility/polarity/chemotaxis Q9Y621 374035 chicken Y592-p 450866 SSVPESDyDNTTASL molecular association, regulation; intracellular localization cell adhesion, altered PXN(INDUCES) 16000375 1 13 222 -KALRN kalirin EC 2.7.11.1; GEF; GEF, Rac/Rho; KINASE; Kinase, protein; Protein kinase, CAMK; Protein kinase, Ser/Thr (non-receptor) O60229 8997 3q21.1-q21.2 human T95-p 1315601 DVCKRGFtVIIDMRG CRAL_TRIO_2 activity, induced 26858404 2 0 0 enhancement of AMPAR-mediated synaptic transmission, LTP induction -DRD2 DRD2 iso2 GPCR, family 1; Membrane protein, integral; Membrane protein, multi-pass; Receptor, GPCR P14416-2 1813 11q23.2 human T225-p 13270200 RRRKRVNtKRSSRAF 7tm_1 receptor desensitization, induced; receptor recycling, induced 23082996 2 0 0 PKC mediated receptor desensitization and internalization -LRP6 LRP6 Membrane protein, integral; Receptor, misc. O75581 4040 12p13.2 human T1572-p 3802448 EPVPPPPtPRSQYLS activity, induced; molecular association, regulation transcription, induced; signaling pathway regulation axin 1(INDUCES) 21887268; 22558232; 25500543 5 0 8 Wnt-beta-catenin signaling; increased B-catennin/TCF4 activity; Regulation of Wnt pathway -TBK1 TBK1 EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, Other; Protein kinase, Ser/Thr (non-receptor) Q9UHD2 29110 12q14.2 human K69-ub 27492601 LNHKNIVkLFAIEEE Pkinase molecular association, regulation; enzymatic activity, induced transcription, induced; signaling pathway regulation IKKG(INDUCES) 23028469 1 2 0 RIG-I-mediated antiviral defense and IFN-activation signaling -ECD SGT1 Transcription, coactivator/corepressor O95905 11319 10q22.2 human S518-p 3178827 EDFECLDsDDDLDFE SGT1 cell cycle regulation 26711270 2 7 0 -TAF7 TAF7 DNA-binding; Transcription, coactivator/corepressor Q15545 6879 5q31.3 human S264-p 468898 LQDKLNEsDEQHQEN molecular association, regulation; acetylation cell cycle regulation; transcription, induced DNA(DISRUPTS) 22711989 1 35 0 -KCNMA1 KCNMA1 Channel, potassium; Endoplasmic reticulum; Membrane protein, integral; Membrane protein, multi-pass Q28265 403984 dog S1084-p 466425 QSSSKKSsSVHSIPS activity, induced 10196172 2 0 0 increases open probability of channel -GLI1 GLI1 C2H2-type zinc finger protein; Oncoprotein; Transcription factor P08151 2735 12q13.3 human S968-p 1034327201 SGSYPTPsPCHENFV molecular association, regulation; intracellular localization transcription, inhibited SUFU(INDUCES) DNA(DISRUPTS) 29662197 1 0 0 localized in cytoplasm -ESR1 ER-alpha DNA-binding; Nuclear receptor; Transcription factor P03372 2099 6q25.1-q25.2 human K268-ac 461006 GGRMLKHkRQRDDGE activity, induced; protein stabilization; molecular association, regulation cell growth, inhibited; transcription, induced; cell motility, inhibited; transcription, altered DNA(INDUCES) 16497729; 19887647; 33544437 4 1 0 MOF depletion promotes proliferation, motility and invasion in HCC; K266/268Q or K266/268R mutations confer resistance to repression by BRCA1 -ANXA7 ANXA7 Calcium-binding; Lipid-binding; Motility/polarity/chemotaxis P20073 310 10q22.2 human T286-p 18908667 VLIEILCtRTNQEIR Annexin molecular association, regulation; intracellular localization ITGB4(INDUCES) 23651924; 26918348 3 1 0 -LEPR LEPR Membrane protein, integral; Receptor, cytokine P48357 3953 1p31.3 human Y986-p 448435 QRQPFVKyATLISNS translation, induced 17726024 16 0 0 cap-dependent translation -Myb Myb DNA-binding; Oncoprotein; Transcription factor P06876 17863 10 A3|10 9.75 cM mouse S528-p 453087 KIKQEVEsPTEKSGN Cmyb_C activity, induced; molecular association, regulation; activity, inhibited transcription, inhibited PIN1(INDUCES) 17077080; 18359295; 8798443 5 11 1 slight increase in conjugation of two and three molecules of SUMO-2 with S528A phospho-mutant under stress; S528 phosphorylation negatively regulates transcription transactivating activity of Myb. -Irs2 IRS2 Adaptor/scaffold; Motility/polarity/chemotaxis P81122 384783 8 A1.1|8 5.35 cM mouse Y671-p 454968 NSCKSDDyMPMSPTS molecular association, regulation; phosphorylation signaling pathway regulation PIK3R1(INDUCES) 23775122; 24811175 3 30 343 promotes GSK3B phosphorylation, regulates aerobic glycolysis -DYRK2 DYRK2 iso2 EC 2.7.12.1; KINASE; Kinase, protein; Protein kinase, CMGC; Protein kinase, dual-specificity (non-receptor) Q92630-2 8445 12q15 human T33-p 11489910 NKRTVLTtQPNGLTT enzymatic activity, inhibited cell cycle regulation; apoptosis, induced 34363019 2 1 0 -ELF4 ELF4 DNA-binding; Oncoprotein; Transcription factor Q99607 2000 Xq26.1 human S369-p 1867984201 ASLELGPsLDEEIPT molecular association, regulation transcription, induced; signaling pathway regulation DNA(INDUCES) 30890658 1 1 0 antviral immune signaling; activates IFN-beta expression; promotes IFN type I transcription -EDC4 EDC4 RNA processing Q6P2E9 23644 16q22.1 human S405-p 1337911000 PDIFSSVsVPPSLKV Ge1_WD40 RNA stability, altered 30467221 1 0 0 increase formation of P bodies -IKBKB IKKB EC 2.7.11.10; KINASE; Kinase, protein; Protein kinase, Other; Protein kinase, Ser/Thr (non-receptor) O14920 3551 8p11.21 human K171-ub 37036402 IIDLGYAkELDQGSL Pkinase activity, induced; phosphorylation signaling pathway regulation 25486864 1 0 0 increases STAT3 phosphorylation, activation and signaling -Tmod3 TMOD3 Cytoskeletal; Motility/polarity/chemotaxis Q9JHJ0 50875 9 D|9 42.3 cM mouse S71-p 456118 FDRERLLsYLEKQAL Tropomodulin molecular association, regulation exocytosis, induced ACTB(DISRUPTS) 25575350 1 16 10 glucose uptake, insulin-stimulated GLUT4 exocytosis -Orc2 ORC2 DNA replication Q60862 18393 1|1 C1.3 mouse S187-p 21507302 SEYSASSsEDDEEAT intracellular localization cell cycle regulation; transcription, induced 21947279 2 0 0 DNA replication induced -NPM1 NPM1 Nucleolus; Oncoprotein; RNA-binding; Translation P06748 4869 5q35.1 human K263-sm 1189201 EKGGSLPkVEAKFIN NPM1-C protein stabilization; molecular association, regulation; intracellular localization apoptosis, inhibited; transcription, induced Akt2(DISRUPTS); Rb(INDUCES) 17535915; 18931307 3 2 0 localize to the centrosomes; in absense of growth factors; promotes cell survival.; wild-type B23 slightly diminished DNA degradation -PLK1 PLK1 EC 2.7.11.21; KINASE; Kinase, protein; Protein kinase, Other; Protein kinase, Ser/Thr (non-receptor) P53350 5347 16p12.2 human S597-p 23203000 LLSSRSAsNRLKAS_ molecular association, regulation cell cycle regulation 14-3-3 zeta(INDUCES) 22202082; 23046929 2 0 0 -CDK9 CDK9 Cell cycle regulation; EC 2.7.11.22; EC 2.7.11.23; KINASE; Kinase, protein; Nuclear receptor co-regulator; Protein kinase, CMGC; Protein kinase, Ser/Thr (non-receptor) P50750 1025 9q34.11 human K49-ac 486373 GQKVALKkVLMENEK Pkinase molecular association, regulation; intracellular localization; enzymatic activity, inhibited; phosphorylation transcription, inhibited Other(INDUCES) 18250157 1 0 0 induces ATP binding, inhibits phosphorylation of RNA POL II -PIP5K1C PIP5K1C Carbohydrate Metabolism - inositol phosphate; EC 2.7.1.68; Kinase, lipid; Motility/polarity/chemotaxis O60331 23396 19p13.3 human K591-sm 1878219602 SVEIVVPkEEDAGVE cell motility, induced; cell growth, induced 31276292 1 0 0 SUMOylation is essential for PIPSK1C-mediated PIP2 generation. -CASR CaR GPCR, family 3; Membrane protein, integral; Membrane protein, multi-pass; Motility/polarity/chemotaxis; Receptor, GPCR P41180 846 3q13.33-q21.1 human S895-p 11488701 TLRRSNVsRKRSSSL activity, induced 9694886 1 1 0 -FOXN2 FOXN2 DNA-binding P32314 3344 2p16.3 human S369-p 799824600 LGDSGYAsQPCAKIS protein degradation; ubiquitination BTRC(INDUCES) 29396548 1 0 0 -DVL2 DVL2 Adaptor/scaffold; Motility/polarity/chemotaxis O14641 1856 17p13.1 human Y27-p 12170304 LDEEETPyLVKIPVP DIX transcription, induced 19920076 1 1 4 regulates Wnt3a/beta-catenin signaling -PAK4 PAK4 EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, STE; Protein kinase, Ser/Thr (non-receptor) O96013 10298 19q13.2 human S181-p 2192531 SRDKRPLsGPDVGTP molecular association, regulation; intracellular localization cell motility, induced; cytoskeletal reorganization 14-3-3 sigma(INDUCES) 35969127 1 62 2 -Ptk2b Pyk2 EC 2.7.10.2; KINASE; Kinase, protein; Nuclear receptor co-regulator; Protein kinase, TK; Protein kinase, tyrosine (non-receptor) P70600 50646 15p12 rat Y402-p 447955 CSIESDIyAEIPDET molecular association, regulation; protein conformation; phosphorylation neural plasticity; apoptosis, altered; cytoskeletal reorganization; cell adhesion, altered FAK(INDUCES) 15096502; 15322113; 20071509; 20826662 86 2 22 hippocampal long-term depression -IL24 IL24 Motility/polarity/chemotaxis; Secreted; Secreted, signal peptide Q13007 11009 1q32.1 human S161-p 41122605 SQENEMFsIRDSAHR activity, induced; intracellular localization cell cycle regulation; carcinogenesis, inhibited; cell growth, inhibited; cell motility, inhibited; signaling pathway regulation 26009991 1 0 0 IL24 maturation and secretion; activates Caspase-9, PARP, and JNK; inhibits the AKT signaling pathway -PGK1 PGK1 Carbohydrate Metabolism - glycolysis and gluconeogenesis; EC 2.7.2.3; KINASE; Kinase, other P00558 5230 Xq21.1 human Y324-p 5233200 GPESSKKyAEAVTRA PGK protein conformation; enzymatic activity, induced carcinogenesis, induced; cell growth, induced; apoptosis, induced 31492635 2 1 6 induce glycolytic activity of PGK1 -FUS hnRNP P2 DNA-binding; Nuclear receptor co-regulator; Oncoprotein; RNA splicing; RNA-binding; SUMO LIGASE P35637 2521 16p11.2 human S257-p 450486 GRGGMGGsDRGGFNK protein stabilization 10913197 1 0 0 Phosphorylation-induced protein stabilization is observed only in those cells which overexpress BCR-ABL. Ectopic expression of phosphomimetic S256D FUS mutant induces apoptosis and inhibits the differentiation of the cells escaping cell death. -CD6 CD6 Cell surface; Membrane protein, integral P30203 923 11q12.2 human S568-p 28095008 NSESSTSsGEDYCNS phosphorylation signaling pathway regulation 23711376 1 0 0 ERK1/2 phosphorylation, MAPK pathway activation -Mybpc3 MYBPC3 Myosin-binding O70468 17868 2|2 E1 mouse S307-p 2846505 RDSFRRDsKLEAPAE cytoskeletal reorganization 21978630 4 7 5 -CTTN Cortactin Actin-binding; Cytoskeletal; Motility/polarity/chemotaxis Q14247 2017 11q13.3 human S418-p 447701 TEERLPSsPVYEDAA protein degradation; molecular association, regulation; ubiquitination; protein conformation carcinogenesis, altered; endocytosis, altered; cell motility, induced; cell motility, altered; cell motility, inhibited; cytoskeletal reorganization; cell adhesion, altered N-WASP(INDUCES); WAVE2(INDUCES) 20444238; 21079800; 21856159; 24188565; 24867096; 26490115 15 90 197 -TNFAIP3 TNFAIP3 Apoptosis; DEUBIQUITINASE; EC 3.4.19.12; Protease; UBIQUITIN LIGASE; Ubiquitin conjugating system; Ubiquitin ligase P21580 7128 6q23.3 human S565-p 40514849 SCHQRSKsDPSRLVR ubiquitination 26649818 1 4 0 cleavage of K63-linked tetraubiquitin ( all 4 sites or S381 alone), enhances ZnF4-mediated substrate ubiquitination -Myl12b MRLC2 Contractile Q3THE2 67938 17|17 E1.3 mouse S3-p 448594 _____MSsKKAKTKT cytoskeletal reorganization; cell adhesion, altered 17928407 1 0 0 induced disassembly of stress fibers and decreased large focal adhesions -IRF3 IRF3 DNA-binding; Transcription factor Q14653 3661 19q13.33 human T207-p 1876336802 EEWEFEVtAFYRGRQ IRF-3 intracellular localization transcription, inhibited 35191555 1 1 0 -ELF2 Elf-2 DNA-binding; Transcription factor Q15723 1998 4q31.1 human S107-p 4779292 EALLHMEsPTCLRDS Elf-1_N protein stabilization carcinogenesis, induced; cell motility, induced; cell growth, induced; transcription, induced 37406957 1 11 8 ELF2 phosphorylation regulates STK24P1 vasculogenic mimicry/ promotes the expression of VM formation-related proteins VEGFR2 and VE-cadherin at the transcriptional level -Mapt Tau ACETYLTRANSFERASE; Acetyltransferase; Cytoskeletal P10637 17762 11 67.79 cM|11 E1 mouse S696-p 449082 PVVSGDTsPRHLSNV molecular association, regulation; protein conformation; phosphorylation SNCA(INDUCES) 21445308; 27834631 145 54 69 dissociates from microtubules (cytoskeleton); Y273 FCGR2B necessary for tau phosphorylation and neurotoxicity -FERMT3 kindlin-3 Cell adhesion Q86UX7 83706 11q13.1 human S484-p 15424197 LSLQRTGsGGPGNHP FERM_M activity, induced; molecular association, regulation; protein conformation cell motility, induced; cell adhesion, induced ICAM1(INDUCES) 25609252; 32730588 2 2 1 induces integrin activation; integrin activation, adhesion and spreading -DAXX DAXX Apoptosis; Nuclear receptor co-regulator; Nucleolus; Transcription, coactivator/corepressor Q9UER7 1616 6p21.32 human S564-p 27571800 LEEESPVsQLFELEI activity, induced; molecular association, regulation MDM2(DISRUPTS) 23405218 2 0 0 p53 transcription activity stimulated -Pth1r PTHR GPCR, family 2; Membrane protein, integral; Membrane protein, multi-pass; Receptor, GPCR P25961 56813 8q32 rat S495-p 2853103 RSGSSSYsYGPMVSH receptor internalization, altered 11773434 2 0 0 -PDCD4 PDCD4 Apoptosis; Tumor suppressor Q53EL6 27250 10q25.2 human S76-p 2588300 RDSGRGDsVSDSGSD protein degradation; molecular association, regulation cell motility, induced; cell growth, induced 14-3-3 beta(INDUCES); BTRC(INDUCES) 17053147; 25002506; 27028868 3 45 84 -CGAS cGAS EC 2.7.7.86 Q8N884 115004 6q13 human S305-p 36128853 MKRKRGGsPAVTLLI Mab-21 enzymatic activity, inhibited apoptosis, inhibited 32345711; 32351706 3 2 0 -ICOSLG ICOSLG Membrane protein, integral O75144 23308 21q22.3 human S285-p 33625706 RDRCLQHsYAGAWAV phosphorylation signaling pathway regulation 24837102 1 0 0 S285 is required for PKC substrate (serine) phosphorylation of ICOSL phosphorylation of proteins recruited to ICOSL, upstream arginine residues in the poximal ICOSL cytoplasmic tail are required to promote cytokine secretion -DAPK3 DAPK3 EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, CAMK; Protein kinase, Ser/Thr (non-receptor); Tumor suppressor O43293 1613 19p13.3 human T265-p 454892 KDPKRRMtIAQSLEH Pkinase phosphorylation; enzymatic activity, induced cell cycle regulation; cytoskeletal reorganization 15611134; 17158456; 31693874 4 2 0 MRLC phosphorylation -Chek1 Chk1 EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, CAMK; Protein kinase, Ser/Thr (non-receptor); Tumor suppressor O35280 12649 9|9 A4 mouse S345-p 447834 LVQGISFsQPTCPEH intracellular localization cell cycle regulation; apoptosis, altered 17242188 212 5 12 -ACSS2 ACSS2 Carbohydrate Metabolism - glycolysis and gluconeogenesis; Carbohydrate Metabolism - propanoate; Carbohydrate Metabolism - pyruvate; EC 6.2.1.1; Ligase Q9NR19 55902 20q11.22 human S267-p 460828 MGDSTSQsPPIKRSC AMP-binding protein stabilization carcinogenesis, induced; cell growth, induced 35190642 1 37 1 inhibits polyubiquitination -MSH6 MSH6 DNA-binding P52701 2956 2p16.3 human S309-p 4274110 RMVTGNGsLKRKSSR intracellular localization DNA repair, induced 36189922 1 14 1 -RUNX3 AML2 DNA-binding; Transcription factor Q13761 864 1p36.11 human S214-p 4733094 RVTPSTPsPRGSLST protein degradation; molecular association, regulation; ubiquitination; activity, inhibited carcinogenesis, induced PIN1(INDUCES) 22580604 1 6 6 The downstream effects occur in the presence of PIN1 -RPS6KB1 p70S6K iso2 EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, AGC; Protein kinase, Ser/Thr (non-receptor); Translation P23443-2 6198 17q23.1 human K485-ac 32640200 PNSGPYKkQAFPMIS molecular association, regulation; enzymatic activity, inhibited; phosphorylation transcription, inhibited Raptor(DISRUPTS) 24652283; 31028173 3 0 0 inhibits mesangial cell hypertrophy and expression of fibronectin and collagen I ; Sirt1,2 deacetylate p70S6K which enhances T389 phosphorylation and it's kinase activity -STXBP1 STXBP1 Vesicle P61764 6812 9q34.11 human S306-p 448743 VSQEVTRsLKDFSSS Sec1 molecular association, regulation STX1A(DISRUPTS) 25716318 3 0 0 reduced vesicle association -TRIM33 TIF1G EC 6.3.2.-; EC 6.3.2.19; KINASE; Kinase, protein; Ligase; Protein kinase, atypical; Transcription, coactivator/corepressor; UBIQUITIN LIGASE; Ubiquitin conjugating system; Ubiquitin ligase Q9UPN9 51592 1p13.2 human Y610-p 25756330 PRHSGPQySMMQPHL molecular association, regulation; intracellular localization transcription, induced; signaling pathway regulation SMAD3(DISRUPTS) 30177833 1 1 1 regulates TGFB-SMAD2/3 signaling and epithelial to mesenchymal transition -Plcb4 PLCB4 Carbohydrate Metabolism - inositol phosphate; EC 3.1.4.11; Phospholipase Q91UZ1 18798 2 F3|2 66.64 cM mouse S890-p 476311 ANVTPQSsSELRPTT activity, induced signaling pathway regulation 33970189 1 6 0 T cell activation; induces TCR signaling -Cacng2 Stargazin Channel, calcium; Membrane protein, integral; Membrane protein, multi-pass O88602 12300 15 E1|15 36.92 cM mouse S240-p 455316 YQRRSRSsSRSTEPS activity, induced; intracellular localization neural plasticity 15664178; 20670832; 24882000 7 0 0 AMPAR immobilization in synaptic membrane; enhances AMPA receptor responses and is required for long-term potentiation; regulates synaptic scaling -ACLY ACLY Carbohydrate Metabolism - citrate (TCA) cycle; EC 2.3.3.8; Lyase; Transferase P53396 47 17q21.2 human Y227-p 1868989000 KVDATADyICKVKWG acetylation; enzymatic activity, induced carcinogenesis, induced 32420483 1 0 0 -IRF2 IRF2 DNA-binding; Transcription factor P14316 3660 4q35.1 human K166-sm 3173815 AVLTSTIkNEVDSTV transcription, inhibited 18514056 1 1 0 -ALDH2 ALDH2 Amino Acid Metabolism - arginine and proline; Amino Acid Metabolism - histidine; Amino Acid Metabolism - lysine degradation; Amino Acid Metabolism - tryptophan; Amino Acid Metabolism - valine, leucine and isoleucine degradation; Carbohydrate Metabolism - ascorbate and aldarate; Carbohydrate Metabolism - butanoate; Carbohydrate Metabolism - glycolysis and gluconeogenesis; Carbohydrate Metabolism - propanoate; Carbohydrate Metabolism - pyruvate; EC 1.2.1.3; Lipid Metabolism - fatty acid; Lipid Metabolism - glycerolipid; Mitochondrial; Other Amino Acids Metabolism - beta-alanine; Oxidoreductase; Secondary Metabolites Metabolism - limonene and pinene degradation P05091 217 12q24.12 human S296-p 62906101 KSPNIIMsDADMDWA Aldedh enzymatic activity, induced 28056995 1 0 0 -PLEK pleckstrin Lipid-binding P08567 5341 2p14 human S113-p 451305 GQKFARKsTRRSIRL activity, induced 7559487 2 0 151 -Camkk1 CAMKK1 EC 2.7.11.17; KINASE; Kinase, protein; Protein kinase, Other; Protein kinase, Ser/Thr (non-receptor) P97756 60341 10q24 rat T108-p 452083 PRAWRRPtIESHHVA enzymatic activity, inhibited 9195898 7 0 5 -Rrad RRAD G protein; G protein, monomeric; G protein, monomeric, RGK NP_445790 83521 19p14 rat S38-p 4700224 APPLHRRsMPVDERD activity, induced 36215501 2 16 0 induces CaV1.2 activity -DACH1 DACH1 DNA-binding; Motility/polarity/chemotaxis; Transcription factor Q9UI36 1602 13q21.33 human K680-ac 28699605 KNRAIVQkRLKKEKK molecular association, regulation cell cycle regulation; carcinogenesis, inhibited; cell growth, inhibited; transcription, altered p53(INDUCES) 23798621 1 1 0 -Axin1 axin 1 Adaptor/scaffold; Tumor suppressor O35625 12005 17 A3.3|17 13.07 cM mouse T480-p 451091 HVQRVMRtPGCQSPG Axin_b-cat_bind activity, induced; molecular association, regulation; intracellular localization cell differentiation, induced; cytoskeletal reorganization GSK3B(INDUCES) 10581160; 21940452; 23972596 5 6 0 axon formation; Phosphorylation plays a role in the activation of axin to modulate Lef/Tcf signaling. Phosphorylation by GSK3beta also leads to increased direct binding of beta-catenin in vitro.; nuclear localization -FBXO22 FBXO22 Ligase; UBIQUITIN LIGASE; Ubiquitin conjugating system; Ubiquitin ligase Q8NEZ5 26263 15q24.2 human S160-p 1875332202 IVVTPMGsGSNRPQE protein stabilization carcinogenesis, inhibited 34795058 1 1 0 induces PD-L1 degradation -KCND3 Kv4.3 Channel, potassium; Membrane protein, integral; Membrane protein, multi-pass Q9UK17 3752 1p13.2 human Y136-p 23045803 GDCCYEEyKDRKREN activity, induced 22198508 1 0 0 positive regulation of Kv4.3 channel and cellular electrical activity -STAU1 STAU iso2 RNA-binding O95793-2 6780 20q13.13 human S20-p 1877718902 DPYSRMQsTYNYNMR dsrm cell growth, inhibited; apoptosis, induced; RNA stability, induced; translation, inhibited 35806349 1 0 0 -CDCA2 CDCA2 Q69YH5 157313 8p21.2 human S981-p 26418520 RRKSFCIsTLANTKA molecular association, regulation cell cycle regulation; chromatin organization, altered PPP1CC(DISRUPTS) 32938714 1 2 1 regulation chromosome condesation rate -BARD1 BARD1 EC 6.3.2.-; EC 6.3.2.19; Ligase; UBIQUITIN LIGASE; Ubiquitin conjugating system; Ubiquitin ligase Q99728 580 2q35 human S186-p 455772 SYEFVSPsPPADVSE cell cycle regulation 15855157 1 12 0 resistance to genotoxic stress (mitomycin C) -Cacna1c CACNA1C Channel, calcium; Membrane protein, integral; Membrane protein, multi-pass Q01815 12288 6 F1|6 55.86 cM mouse S1545-p 467228 VACKRLVsMNMPLNS GPHH activity, induced 20479240 4 0 0 mediates Ca2+ current facilitation -Rack1 RACK1 Adaptor/scaffold; G protein; G protein, heterotrimeric; G protein, heterotrimeric beta; Motility/polarity/chemotaxis; Nuclear receptor co-regulator P63245 83427 10q21 rat T50-p 23136904 WKLTRDEtNYGIPQR protein degradation; molecular association, regulation; intracellular localization autophagy, induced; apoptosis, inhibited; translation, induced beclin 1(INDUCES) 30580718 3 2 9 reduced infarct volume -BMI1 BMI1 EC 6.3.2.-; Ligase; Motility/polarity/chemotaxis; Oncoprotein; UBIQUITIN LIGASE; Ubiquitin conjugating system; Ubiquitin ligase P35226 648 10p12.2 human K81-ub 15385389 TLQDIVYkLVPGLFK protein degradation cell growth, induced 31921558 1 0 3 -HMGN2 HMGN2 DNA-binding P05204 3151 1p36.11 human K3-ac 458861 _____MPkRKAEGDA HMG14_17 molecular association, regulation carcinogenesis, inhibited; transcription, inhibited DNA(DISRUPTS) 10207070; 27358110 3 1 0 -WAC WAC Adaptor/scaffold Q9BTA9 51322 10p12.1|10p12.1-p11.2 human T457-p 469444 YVSPRIStPQTNTVP molecular association, regulation; phosphorylation cell cycle regulation PLK1(INDUCES) 30021153 1 9 14 -TRPC7 TRPC7 Channel, calcium; Membrane protein, integral; Membrane protein, multi-pass Q9HCX4 57113 5q31.1 human S714-p 41287737 APFNLVPsPKSFYYL cytoskeletal reorganization 26391658 1 0 0 calcium levels decreased, organized alpha-SMA-containing stress fibers and OB-cadherin utilization at adherens junctions increased -Rab1A RAB1A G protein; G protein, monomeric; G protein, monomeric, Rab P62821 19324 11 A3.1|11 12.92 cM mouse K49-ub 1883494502 STIGVDFkIRTIELD molecular association, regulation GDI1(DISRUPTS) 35343654 1 0 0 inhibit the post-ER tra?cking of TLRs -Ulk1 ULK1 Autophagy; EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, Other; Protein kinase, Ser/Thr (non-receptor) O70405 22241 5|5 F mouse T635-p 4699275 PSFDFPKtPSSQNLL cell cycle regulation; autophagy, induced; cell growth, induced 32516310 1 3 5 -Rab1A RAB1A G protein; G protein, monomeric; G protein, monomeric, Rab P62821 19324 11 A3.1|11 12.92 cM mouse K61-ub 7328566 ELDGKTIkLQIWDTA Ras molecular association, regulation GDI1(DISRUPTS) 35343654 1 1 1 inhibit the post-ER tra?cking of TLRs -H3c1 H3 DNA-binding P68433 360198 13|13 A3.1 mouse K79-m2 1458615 REIAQDFkTDLRFQS Histone cell cycle regulation; carcinogenesis, induced; cell growth, induced; cell differentiation, induced; chromatin organization, altered; transcription, induced 17493269; 18977325; 19264835; 19434510; 19544450; 23361907; 23428873 40 21 10 -Map3k8 Cot EC 2.7.11.25; KINASE; Kinase, protein; Oncoprotein; Protein kinase, STE; Protein kinase, Ser/Thr (non-receptor) Q07174 26410 18 A1|18 2.73 cM mouse S443-p 478514 EVLRRQRsLYIDLGA molecular association, regulation; phosphorylation signaling pathway regulation 14-3-3 zeta(INDUCES); 14-3-3 gamma(INDUCES) 24912162 1 2 0 induces Cot signaling -TRPC4 TRPC4 Channel, calcium; Membrane protein, integral; Membrane protein, multi-pass Q9UBN4 7223 13q13.3 human S688-p 26572402 KMRRKPEsFGTIGRR activity, induced 28124739 1 1 0 -STK25 YSK1 EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, STE; Protein kinase, Ser/Thr (non-receptor) O00506 10494 2q37.3 human T174-p 469056 DTQIKRNtFVGTPFW Pkinase molecular association, regulation; intracellular localization; enzymatic activity, induced apoptosis, induced; signaling pathway regulation CCM2(INDUCES); TrkA(INDUCES) 15037601; 22782892 3 34 129 -CDC25A CDC25A EC 3.1.3.48; Motility/polarity/chemotaxis; PHOSPHATASE; Protein phosphatase, dual-specificity P30304 993 3p21.31 human S185-p 1874397802 SAPARMLsSNERDSS M-inducer_phosp protein degradation; ubiquitination cell cycle regulation; apoptosis, inhibited 34363019 1 1 0 -Crtc1 TORC1 Transcription factor Q68ED7 382056 8|8 B3.3 mouse S151-p 481986 TSWRRTNsDSALHQS TORC_M intracellular localization transcription, induced 18758446; 28076781 7 17 5 nuclear import and retention ; S151A mutatnt is constitutively nuclear -MYC Myc DNA-binding; Nucleolus; Oncoprotein; Transcription factor P01106 4609 8q24.21 human K67-sm 40724404 PSEDIWKkFELLPTP Myc_N protein degradation; molecular association, regulation; ubiquitination carcinogenesis, induced; cell growth, induced; transcription, induced; transcription, inhibited JNK1(INDUCES) 25895136; 27239040 2 2 0 -TBL1X TBL1X Nuclear receptor co-regulator; Transcription, coactivator/corepressor O60907 6907 Xp22.31-p22.2 human K560-sm 20745208 CWNARGDkVGASASD acetylation; molecular association, regulation carcinogenesis, induced; cell growth, induced; transcription, induced; signaling pathway regulation TCF4(INDUCES); SMRT(DISRUPTS); N-CoR1(DISRUPTS); HDAC3(DISRUPTS); CTNNB1(INDUCES) DNA(INDUCES) 21777810; 27129164 2 0 0 TCF4 was bound to TBL1X but not TBL1XR1, sumoylation enhances the recruitment to Wnt target gene promoters, activates Wnt signaling pathway ; induces histone acetylation -TRIM9 TRIM9 iso5 EC 6.3.2.-; UBIQUITIN LIGASE; Ubiquitin conjugating system; Ubiquitin ligase Q9C026-5 114088 14q22.1 human S76-p 1046182900 SLYSEADsGYGSYGG protein stabilization 29669288 1 0 0 MKK6 enhances TRIM9s phosphorylation to inhibit Its ubiquitination -APOBEC3G APOBEC3G EC 3.5.4.-; Hydrolase; RNA processing; RNA-binding Q9HC16 60489 22q13.1 human K334-ub 11956700 TLAEAGAkISIMTYS NAD2 protein degradation 19887642 1 0 0 -H2AC11 H2A.1 DNA-binding P0C0S8 8329 6p22.1 human K13-ac 7806205 QGGKARAkAKTRSSR Histone molecular association, regulation polybromo 1(INDUCES) 20368734 2 1 1 varying site specificity binding for each bromodomain 1-6 -MCM7 MCM7 DNA replication; EC 3.6.4.12; Motility/polarity/chemotaxis P33993 4176 7q22.1 human S121-p 3189844 RDPGMVRsPQNQYPA MCM_N molecular association, regulation; intracellular localization; phosphorylation cell cycle regulation; signaling pathway regulation MCM5(INDUCES); CDC45L(INDUCES); MCM3(INDUCES) 23720738 1 17 3 induces loading onto chromatin, induces activation of ATR/Chk1/CDK checkpoint pathway -Cav1 caveolin-1 Adaptor/scaffold; Motility/polarity/chemotaxis; Nuclear receptor co-regulator P49817 12389 6|6 A2 mouse Y14-p 448422 VDSEGHLyTVPIREQ molecular association, regulation; intracellular localization endocytosis, induced; carcinogenesis, induced; cell motility, induced; cell growth, induced; cell adhesion, altered RHOA(INDUCES) 16113676; 16943184; 21829547; 28805811; 32152405; 35740528; 37419919 55 45 830 -LIMK1 LIMK1 EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, Ser/Thr (non-receptor); Protein kinase, TKL P53667 3984 7q11.23 human T508-p 447808 PDRKKRYtVVGNPYW PK_Tyr_Ser-Thr activity, induced; molecular association, regulation; phosphorylation; enzymatic activity, induced cell cycle regulation; cell motility, induced NISCH(INDUCES) 10652353; 11784854; 15660133; 18332102; 21423216; 22214762; 23934191; 29058761 30 2 1 cytokinesis failure that acted as a precursor to centrosome ampli?cation; neutrophil crawling behavior -CBL CBL Adaptor/scaffold; EC 6.3.2.-; EC 6.3.2.19; Ligase; Motility/polarity/chemotaxis; Oncoprotein; UBIQUITIN LIGASE; Ubiquitin conjugating system; Ubiquitin ligase P22681 867 11q23.3 human Y731-p 448530 QQIDSCTyEAMYNIQ activity, induced; protein degradation; molecular association, regulation; intracellular localization; protein conformation; enzymatic activity, induced; phosphorylation cell growth, induced; cell motility, altered; signaling pathway regulation; cell growth, altered Src(INDUCES); PIK3R1(INDUCES); PIK3CA(INDUCES); CTNNA1(INDUCES) 11994282; 12604776; 14739300; 15922744; 16844778; 21967979; 25784557; 33512474; 9890970; 9988765 17 1 34 ; integrin-mediated platelet outside-in signaling for clot retraction and platelet spreading, ; induces cytokine signaling -AFF4 MCEF Oncoprotein; Transcription factor Q9UHB7 27125 5q31.1 human S388-p 470820 KDDLKLSsSEDSDGE AF-4 molecular association, regulation carcinogenesis, induced; transcription, induced PAX2(INDUCES) 37063434 1 4 0 -TRAIP TRAIP EC 6.3.2.-; Ligase; Nucleolus; UBIQUITIN LIGASE; Ubiquitin conjugating system; Ubiquitin ligase Q9BWF2 10293 3p21.31 human K127-sm 53529101 SLQQALGkAEMLCST protein stabilization; ubiquitination; intracellular localization 26820530 2 0 0 inhibits ubiquitination -MAFA MAFA DNA-binding; Oncoprotein; Transcription factor; Tumor suppressor O57342 quail S272-p 456030 RGFPRETsPPAAPKT cell differentiation, altered; transcription, altered 15963504 3 4 0 -RUNX3 AML2 DNA-binding; Transcription factor Q13761 864 1p36.11 human T153-p 6097700 RGKSFTLtITVFTNP Runt protein stabilization; intracellular localization cell cycle regulation; transcription, altered 18767071 1 1 0 -AHR AHR DNA-binding; Transcription factor P35869 196 7p21.1 human T731-p 1874101932 FEPSPYPtTSSLEDF protein degradation; ubiquitination autophagy, induced; transcription, induced 34198826 1 0 0 -BAD BAD Apoptosis Q92934 572 11q13.1 human R96-m2 51576301 EPSPFRGrSRSAPPN Bcl-2_BAD molecular association, regulation; phosphorylation 14-3-3 beta(DISRUPTS) 21444773 1 0 0 methylation of BAD inhibits S99 phosphorylation by Akt, and binding to 14-3-3-beta -Opn4 melanopsin GPCR, family 1; Membrane protein, integral; Membrane protein, multi-pass; Receptor, GPCR Q9QXZ9 30044 14|14 B mouse S388-p 23257065 SYRSTHRsTLSSQSS molecular association, regulation; protein conformation ARRB1(INDUCES) 32236094 1 1 1 -Ppp1r2 PPP1R2 Inhibitor; Motility/polarity/chemotaxis; Protein phosphatase, regulatory subunit P50411 192361 11q22 rat T73-p 449051 MKIDEPDtPYHNMIG IPP-2 molecular association, regulation PPP1CA(DISRUPTS) 24189275 11 4 0 -PTTG1 Securin Cell cycle regulation; Oncoprotein O95997 9232 5q33.3 human S89-p 31879178 KQKQPSFsAKKMTEK Securin protein degradation; ubiquitination; enzymatic activity, induced chromatin organization, altered 24781523 1 2 0 1) Phosphorylation of securing leads to premature activation of separase. 2) Prevention of securin phosphorylation leads to impaired chromosome segregation and thereby leads to DNA damage. -PARP1 PARP1 DNA repair, damage; EC 2.4.2.30; Nuclear envelope; Nuclear receptor co-regulator; Nucleolus; Transferase P09874 142 1q42.12 human K524-ac 459008 NKSEKRMkLTLKGGA molecular association, regulation transcription, induced NFkB-p105(INDUCES) 16204234 1 1 0 -HIF1A HIF1A Autophagy; DNA-binding; Transcription factor Q16665 3091 14q23.2 human S641-p 470105 DIKILIAsPSPTHIH activity, induced; protein stabilization; molecular association, regulation; intracellular localization apoptosis, inhibited; transcription, induced; transcription, altered HSPA9B(DISRUPTS); PIN1(INDUCES); Exportin-1(DISRUPTS) 16954218; 18687685; 26784107; 36825991 4 2 0 -Tp53 p53 Activator; DNA-binding; Motility/polarity/chemotaxis; Nuclear receptor co-regulator; Transcription factor; Tumor suppressor P02340 22059 11 B3|11 42.83 cM mouse K369-ac 458982 HSSYLKTkKGQSTSR activity, induced transcription, induced 33323382 25 3 0 P53K Q/- mice died prematurely due to anemia, loss of hematopoiesis stem cells, Loss of stem cells in the testis, activation in p53 KQ/- mice without robust p53 stabilization,p53-KQ/- mutant leads to effective suppression of tumor development in a pancreatic ductal adenocarcinoma mouse model, mutant proteins extended the life-span of a PDAC mouse model -Myc Myc DNA-binding; Nucleolus; Oncoprotein; Transcription factor P01108 17869 15 D1|15 26.19 cM mouse T73-p 448496 KKFELLPtPPLSPSR Myc_N protein degradation; molecular association, regulation cell differentiation, altered; carcinogenesis, inhibited; cell growth, inhibited; apoptosis, induced; transcription, inhibited PIN1(INDUCES) 15048125; 19223464; 22405651; 26136212; 34625423; 34710087; 35380701 83 40 30 -FANCG FANCG DNA repair, damage O15287 2189 9p13.3 human S7-p 453422 _MSRQTTsVGSSCLD molecular association, regulation FANCD2(INDUCES); XRCC3(INDUCES); BRCA2(INDUCES) 18212739 2 1 0 and direct interaction of BRCA2?FANCD2 -Pam PAM EC 1.14.17.3; EC 4.3.2.5; Lyase; Membrane protein, integral; Oxidoreductase; Vesicle P14925 25508 9q37 rat S949-p 453092 DRVSTEGsDQEKDED intracellular localization; enzymatic activity, induced 11524414; 20374556 3 16 1 -Neurod1 NEUROD1 DNA-binding; Transcription factor Q64289 29458 3q24 rat S336-p 451110 IPIDNIMsFDSHSHH intracellular localization cell growth, altered 14741104; 25752781 3 0 0 -BCR/ABL BCR-ABL1 EC 2.7.10.2; Fusion protein; KINASE; Kinase, protein; Protein kinase, TK; Protein kinase, tyrosine (non-receptor) A9UF07 human Y246-p 22779529 SCGVDGDyEDAELNP carcinogenesis, induced; cell growth, induced; apoptosis, inhibited; signaling pathway regulation 22169110 1 1 137 RAF-MEK-ERK pathway -AIFM1 PDCD8 Apoptosis; EC 1.-.-.-; Mitochondrial; Oxidoreductase O95831 9131 Xq26.1 human T281-p 1872824900 GAEVKSRtTLFRKIG Pyr_redox_2 molecular association, regulation; intracellular localization carcinogenesis, induced; apoptosis, inhibited KPNA4(DISRUPTS) 33867848 1 1 0 -Htt Huntingtin Cytoskeletal P51111 29424 14q21 rat S1170-p 465620 EQTSTPMsPKKGGEA apoptosis, inhibited 17611284 4 29 2 regulates neuronal death through a p53-dependent pathway -Grin2b NMDAR2B Channel, calcium; Channel, ligand-gated; Membrane protein, integral; Membrane protein, multi-pass Q01097 14812 6 G1|6 66.38 cM mouse S1303-p 450171 NKLRRQHsYDTFVDL NMDAR2_C activity, induced; molecular association, regulation; receptor desensitization, altered; receptor internalization, inhibited neural plasticity; signaling pathway regulation NMDAR1(INDUCES); DAPK1(INDUCES) 20141836; 24038144; 28614711; 30916039; 31981057; 32358047; 33157174; 33250715 48 14 31 -Spag5 SPAG5 Cell cycle regulation Q7TME2 54141 11 B5|11 46.74 cM mouse T24-p 11270701 KGKPAMStPLRELKL cell cycle regulation 19806032 1 3 0 T24/66/447A mutant impairs meiosis progression -Egfr EGFR EC 2.7.10.1; KINASE; Kinase, protein; Membrane protein, integral; Oncoprotein; Protein kinase, TK; Protein kinase, tyrosine (receptor) Q01279 13649 11 A2|11 9.41 cM mouse S1071-p 448052 AFLQRYSsDPTGAVT carcinogenesis, induced 36624189 17 2 8 -PPARG PPAR-gamma iso2 DNA-binding; Nuclear receptor; Transcription factor P37231-2 5468 3p25.2 human K367-sm 12004433 FGDFMEPkFEFAVKF Hormone_recep carcinogenesis, inhibited; cell growth, inhibited; transcription, altered 26244663 8 0 0 -HABP4 HABP4 Transcription regulation Q5JVS0 22927 9q22.32 human T354-p 11380902 RKPANDItSQLEINF IHABP4_N molecular association, regulation; intracellular localization RACK1(DISRUPTS) 14699138 1 0 0 HABP4 associates with RACK1 in the nucleus but exits after activation with PMA -Tiam2 TIAM2 Apoptosis; GEF; GEF, Rac/Rho Q6ZPF3 24001 17 A1|17 1.99 cM mouse T1662-p 478913 STKRGRGtLLKAQTR molecular association, regulation cell growth, altered MAP1B(DISRUPTS); MAP1A(DISRUPTS); 14-3-3 epsilon(DISRUPTS) 17320046 1 0 0 inhibits neurite growth; suppresses Rac1 activation in vivo -EIF5A2 EIF5A2 Q9GZV4 56648 3q26.2 human K67-ub 21173818 GIDIFTGkKYEDICP protein degradation 35064108 1 5 0 regulate EMT, and may inhibit the metastasis of CRC -Mapt Tau ACETYLTRANSFERASE; Acetyltransferase; Cytoskeletal P10637 17762 11 67.79 cM|11 E1 mouse S554-p 447930 NVRSKIGsTENLKHQ Tubulin-binding protein degradation; molecular association, regulation; protein conformation neural plasticity Tau(INDUCES) 17573348; 21445308; 33428131; 34220446 118 25 2 -RIGI RIGI EC 3.6.4.13; Hydrolase O95786 23586 9p21.1 human K888-sm 63243404 TFEIPVIkIESFVVE RIG-I_C-RD phosphorylation 28250012 1 0 0 dephosphorylation -SMAD3 SMAD3 DNA-binding; Nuclear receptor co-regulator; Transcription factor P84022 4088 15q22.33 human S422-p 449603 GSPSIRCsSVS____ transcription, induced; transcription, altered 25140527; 9380693 2 0 0 The triple mutants(S422/423/425A and S422/423/425D) were used in these experiments -Pip5k1b PIP5K1B Carbohydrate Metabolism - inositol phosphate; EC 2.7.1.68; Kinase, lipid P70181 18719 19|19 B mouse S214-p 455789 STYKRRAsRKEREKP PIP5K activity, inhibited 11087761 1 0 0 -PFKFB2 PFKFB2 Carbohydrate Metabolism - fructose and mannose; EC 2.7.1.105; EC 3.1.3.46; Kinase, other; Motility/polarity/chemotaxis; Phosphatase (non-protein) P26285 287019 cow T476-p 465673 TPLSSSNtIRRPRNY enzymatic activity, induced 2846551 2 3 7 -USP15 USP15 DEUBIQUITINASE; EC 3.4.19.12; Protease; Ubiquitin conjugating system; Ubiquitin-specific protease Q9Y4E8 9958 12q14.1 human T219-p 25757905 EQKNEDGtWPRGPST Ubiquitin_3 molecular association, regulation; ubiquitination; intracellular localization SART3(DISRUPTS) 31330151 1 2 1 inhibits deubiquitination of PRP31 -HDAC5 HDAC5 DEACETYLASE; Deacetylase; EC 3.5.1.98; Hydrolase Q9UQL6 10014 17q21.31 human S279-p 4788487 KVAERRSsPLLRRKD molecular association, regulation; intracellular localization; protein conformation; phosphorylation; enzymatic activity, induced neural plasticity; transcription, inhibited SMRT(INDUCES); TBL1X(INDUCES); TBL1XR1(INDUCES); 14-3-3 beta(DISRUPTS); 14-3-3 beta(INDUCES); N-CoR1(DISRUPTS); GPS2(INDUCES); HDAC3(INDUCES) 20716686; 21081666; 22243750; 23161540 6 19 1 PKA activation and phosphorylation of this site may reduce phosphorylation of HDAC5 S498 and promotes nuclear retention; regulates HDAC5's import-export from nucleus -Ssb SSB Transcription initiation complex P32067 20823 2 C2|2 40.95 cM mouse T301-p 452110 LLRNKKVtWKVLEGH RRM_3 activity, induced; intracellular localization 18836485 1 1 0 nuclear export -Mtf1 MTF1 C2H2-type zinc finger protein; Transcription factor Q07243 17764 4 D2.2|4 57.91 cM mouse K627-sm 1873213008 SVPVIIIkQEEACQC molecular association, regulation MTF1(INDUCES) 22021037 1 0 0 MTF1 binds sumoylated MTF1 (disrupted by zinc treatment), gel permeation chromatography -CTNNB1 CTNNB1 Actin-binding; Cell adhesion; Motility/polarity/chemotaxis; Nuclear receptor co-regulator; Oncoprotein; Transcription factor P35222 1499 3p22.1 human K49-m3 63355300 TAPSLSGkGNPEEED molecular association, regulation cell differentiation, induced; transcription, inhibited SUZ12(INDUCES); CDH1(INDUCES); JARID2(INDUCES) 28329675 1 0 0 -KDM4B JMJD2B DEMETHYLASE; Demethylase; EC 1.14.11.-; Oxidoreductase O94953 23030 19p13.3 human T305-p 484516 IDYGKVAtQCTCRKD protein stabilization; ubiquitination 28945223 1 1 0 -SFMBT1 SFMBT1 Unknown function Q9UHJ3 51460 3p21.1 human P651-hy 1877475702 NKRIGRPpGGHSNLA protein degradation; ubiquitination carcinogenesis, induced; cell growth, induced 32023483 1 1 0 -ITGAM ITGAM Cell adhesion; Membrane protein, integral; Motility/polarity/chemotaxis P11215 3684 16p11.2 human S1142-p 467233 RQYKDMMsEGGPPGA Integrin_alpha activity, induced; molecular association, regulation cell motility, altered; cell adhesion, altered ICAM1(INDUCES); ICAM2(INDUCES) 16857989 2 0 0 important for emigration of leukocytes from bloodstream to tissues in vivo -DPYSL3 CRMP-4 Hydrolase Q14195 1809 5q32 human T509-p 454328 PVFDLTTtPKGGTPA carcinogenesis, induced 30154149 3 50 16 -NR1I2 PXR DNA-binding; Nuclear receptor O75469 8856 3q13.33 human S167-p 30259802 KTFDTTFsHFKNFRL transcription, inhibited 24184507 1 1 0 -SREBF1 SREBP-1 iso3 DNA-binding; Membrane protein, integral; Membrane protein, multi-pass; Transcription factor P36956-3 6720 17p11.2 human S314-p 458357 IEKRYRSsINDKIIE HLH molecular association, regulation transcription, inhibited SREBP-1 iso3(DISRUPTS) 16381800 4 1 0 inhibits lipogenesis -Aqp5 AQP5 Channel, misc.; Membrane protein, integral; Membrane protein, multi-pass; Transporter; Transporter, aquaporin family Q9WTY4 11830 15 F1|15 56.13 cM mouse T259-p 460666 HREERKKtIELTAH_ intracellular localization signaling pathway regulation 21633078 3 0 0 cAMP signaling -FGFR2 FGFR2 iso18 EC 2.7.10.1; KINASE; Kinase, protein; Membrane protein, integral; Oncoprotein; Protein kinase, TK; Protein kinase, tyrosine (receptor) P21802-18 2263 10q26.13 human Y655-p 472824 RDINNIDyYKKTTNG PK_Tyr_Ser-Thr molecular association, regulation; intracellular localization CD44(INDUCES) 27107424 2 8 66 colocalization with CD44 -HTT Huntingtin Cytoskeletal P42858 3064 4p16.3 human S2112-p 1870026106 KSQCWTRsDSALLEG activity, induced 32668197 1 1 0 -NADK2 NADK2 EC 2.7.1.23 Q4G0N4 133686 5p13.2 human S376-p 17439149 EEPKILFsIREPIAN enzymatic activity, inhibited 26577408 1 1 0 -Cgas cGAS EC 2.7.7.86 Q8C6L5 214763 9|9 E1 mouse K271-ub 59117704 SKFRKIIkEEVKEIK Mab-21 protein degradation 27637147 2 1 0 -Ctnnb1 CTNNB1 Actin-binding; Cell adhesion; Motility/polarity/chemotaxis; Nuclear receptor co-regulator; Oncoprotein; Transcription factor Q9WU82 84353 8q32 rat T41-p 447583 GIHSGATtTAPSLSG protein degradation 14985333 102 3 0 -CKMT1A CKMT1A Amino Acid Metabolism - arginine and proline; EC 2.7.3.2; Kinase, other; Mitochondrial P12532 548596 15q15.3 human Y153-p 475235 ASKIRSGyFDERYVL protein stabilization; molecular association, regulation; enzymatic activity, induced carcinogenesis, induced; cell growth, induced; signaling pathway regulation HSP75(DISRUPTS) 30174304 1 12 183 regulates PCr energy shuttle pathway -F2RL1 F2RL1 GPCR, family 1; Membrane protein, integral; Membrane protein, multi-pass; Receptor, GPCR P55085 2150 5q13.3 human S384-p 12202366 KKHSRKSsSYSSSST receptor desensitization, induced; molecular association, regulation; phosphorylation signaling pathway regulation ARRB1(INDUCES); ARRB2(INDUCES) 33073187 1 2 4 inhibits ERK phosphorylation and signaling; regulates calcium signaling -MRE11 MRE11A Cell cycle regulation; DNA repair, damage; DNA-binding; Deoxyribonuclease P49959 4361 11q21 human R574-m2 62978405 NKGRGRGrGRRGGRG DNA repair, altered 15741314 0 1 0 -Irf7 IRF7 DNA-binding; Transcription factor P70434 54123 7|7 F5 mouse S429-p 1276104 EGVSSLDsSSLGLCL transcription, induced DNA(INDUCES) 15743772 1 0 0 -GLI1 GLI1 C2H2-type zinc finger protein; Oncoprotein; Transcription factor P08151 2735 12q13.3 human S204-p 34426682 GDMSSPNsTGIQDPL molecular association, regulation; intracellular localization transcription, inhibited SUFU(INDUCES) DNA(DISRUPTS) 29662197 1 0 1 localized in cytoplasm -Cdkn1b p27Kip1 Cell cycle regulation; Inhibitor; Oncoprotein; Protein kinase, regulatory subunit P46414 12576 6 G1|6 65.77 cM mouse T187-p 447875 NAGTVEQtPKKPGLR ubiquitination cell cycle regulation; apoptosis, altered; cell growth, induced; cell differentiation, induced; cell growth, altered 11565035; 19966802; 20810788 54 1 1 neurite outgrowth -SH3BP2 SH3BP2 Adaptor/scaffold F1ND54 chicken Y426-p 449093 NDDSDDDyEKVELPT molecular association, regulation VAV3(INDUCES) 24406398 5 0 0 Rac1 activation -PARP1 PARP1 DNA repair, damage; EC 2.4.2.30; Nuclear envelope; Nuclear receptor co-regulator; Nucleolus; Transferase P09874 142 1q42.12 human T594-p 1876872802 RSWGRVGtVIGSNKL WGR intracellular localization transcription, inhibited 35460603 1 1 0 -HCK Hck EC 2.7.10.2; KINASE; Kinase, protein; Oncoprotein; Protein kinase, TK; Protein kinase, tyrosine (non-receptor) P08631 3055 20q11.21 human Y522-p 448322 YTATESQyQQQP___ activity, inhibited cell growth, altered 2503711 3 8 326 -Opn4 melanopsin GPCR, family 1; Membrane protein, integral; Membrane protein, multi-pass; Receptor, GPCR Q9QXZ9 30044 14|14 B mouse S384-p 55544700 HPSLSYRsTHRSTLS activity, inhibited 27181062 1 0 0 a reduced response duration and magnitude -NKD2 NKD2 Cell development/differentiation; Ubiquitin conjugating system Q969F2 85409 5p15.33 human S223-p 3949685 SAHVRRPsTDPQPCS protein stabilization signaling pathway regulation 30941853 1 1 3 promotes cell surface delivery of TGFa, EGFR transactivation, regulates PKA/AKAP12/MMP/NKD2 signaling for TGFa release -Nfkb2 NFkB-p100 DNA-binding; Oncoprotein; Transcription factor Q5U2Z4 309452 1q54 rat S864-p 450166 STEVKEDsAYGSQSV apoptosis, inhibited 21550382 7 1 0 induces cell survival -TRIM65 TRIM65 Ubiquitin conjugating system Q6PJ69 201292 17q25.1 human S167-p 1868914501 LELRKQSsQIQNSAC carcinogenesis, inhibited; signaling pathway regulation 31332286 1 1 0 dephosphorylated form (6A mutant) contributes to TRIM65 function in tumor progression -Tardbp TDP-43 RNA-binding Q921F2 230908 4|4 E2 mouse S410-p 3084601 SSMDSKSsGWGM___ ubiquitination apoptosis, induced DROSHA(DISRUPTS); hnRNP P2(DISRUPTS) 23840565; 26102026 54 4 0 Phosphorylated, ubiqitinated protein forms insoluble aggregates.; disrupts interaction between Drosha and FUS -Hdac5 HDAC5 DEACETYLASE; Deacetylase; EC 3.5.1.98; Hydrolase F1LM64 84580 10q32.1 rat S322-p 447996 RPLSRTQsSPLPQSP intracellular localization transcription, induced 26647181 24 7 4 nuclear export, MEF2 transcriptional activity induced, induction of anti-depressant behavior -Bcl10 Bcl-10 Apoptosis; Transcription, coactivator/corepressor; Tumor suppressor Q9Z0H7 12042 3|3 H2 mouse S134-p 467254 AGATNNLsRCNSDES activity, induced; protein degradation 17502353 3 8 3 -PAK6 PAK6 EC 2.7.11.1; KINASE; Kinase, protein; Nuclear receptor co-regulator; Protein kinase, STE; Protein kinase, Ser/Thr (non-receptor) Q9NQU5 56924 15q15.1 human S113-p 5208141 TSRRRAQsLGLLGDE molecular association, regulation; intracellular localization 14-3-3 sigma(INDUCES) 35969127 2 4 10 -Nr0b2 NR0B2 Nuclear receptor; Nuclear receptor co-regulator; Transcription, coactivator/corepressor Q62227 23957 4 D2.3|4 66.25 cM mouse S26-p 7596703 TILYALLsPSPRTRP protein stabilization 19390091 1 1 0 -SIGLEC9 Siglec-9 Membrane protein, integral; Receptor, misc. Q9Y336 27180 19q13.41 human Y456-p 460275 QEATDTEySEIKIHR transcription, inhibited; signaling pathway regulation 33431669 1 2 32 inhibits TLR4 signaling -Npas4 NPAS4 DNA-binding Q8BGD7 225872 19|19 A mouse S577-p 1871095700 LYEKLPPsPSSPGNG molecular association, regulation neural plasticity; transcription, induced CBP(INDUCES) 31801086 1 1 0 -Ppp1r1b DARPP-32 Motility/polarity/chemotaxis; Protein phosphatase, regulatory subunit Q60829 19049 11|11 D mouse S92-p 466340 LQTISNLsENQASEE DARPP-32 molecular association, regulation signaling pathway regulation PPP1CA(INDUCES) 36792029 3 2 0 regulates DARPP-32-PP1-GRIA1 signaling pathway. -IWS1 IWS1 Transcription factor Q96ST2 55677 2q14.3 human S720-p 477902 PQRRRMNsTGGQTPR molecular association, regulation; intracellular localization carcinogenesis, induced; RNA splicing, induced; cell motility, induced THOC4(DISRUPTS); SPT6(DISRUPTS) 24462114 1 35 769 recruitment of SetD2 to RNA Pol II elongation complex, regulates alternative splicing -TPT1 TPT1 Calcium-binding; Microtubule-binding P13693 7178 13q14.13 human S64-p 3146607 PEGEGTEsTVITGVD TCTP protein degradation; protein conformation carcinogenesis, inhibited; apoptosis, induced 29719201; 34675258 4 1 0 -NDUFB6 NDUFB6 EC 1.6.5.3; EC 1.6.99.3; Energy Metabolism - oxidative phosphorylation; Membrane protein, integral; Mitochondrial; Oxidoreductase O95139 4712 9p21.1 human S55-p 33402203 NKFLENKsPWRKMVH NDUF_B6 activity, induced cell cycle regulation 24746669 1 1 0 increases mitochondrial respiration for G/2M transition -NFE2L2 NRF2 DNA-binding; Transcription factor Q16236 4780 2q31.2 human T559-p 10292701 LLKKQLStLYLEVFS bZIP_Maf intracellular localization transcription, induced 19668370 1 1 0 moderate effects observed only in NFE2L2-5A mutant -Wnk4 WNK4 EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, Other; Protein kinase, Ser/Thr (non-receptor) Q80UE6 69847 11|11 D mouse S1169-p 477191 SCRQRRLsKGSFPTS activity, inhibited 17360471 6 4 0 WNK4 phosphorylation abrogates its basal inhibition of ENaC and ROMK channels -Ptpn2 PTPN2 EC 3.1.3.48; Motility/polarity/chemotaxis; PHOSPHATASE; Protein phosphatase, tyrosine (non-receptor) Q06180 19255 18|18 E1 mouse T261-p 10997733 YRMGLIQtPDQLRFS Y_phosphatase phosphorylation; enzymatic activity, induced carcinogenesis, induced; apoptosis, inhibited 37000627 1 1 1 dephosphorylates CD3Z -STK11 LKB1 Autophagy; EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, CAMK; Protein kinase, Ser/Thr (non-receptor); Tumor suppressor F1S6Q9 pig S339-p 448147 SSKIRRLsACKQQ__ signaling pathway regulation 23799098 33 2 3 simvastatin-induced signaling for the closure of K-ATP channel -EPRS1 EPRS Aminoacyl-tRNA synthetase; Cofactor and Vitamin Metabolism - porphyrin and chlorophyll; EC 6.1.1.15; EC 6.1.1.17; Ligase; Translation; Translation regulation P07814 2058 1q41 human S999-p 9720900 NQGGGLSsSGAGEGQ molecular association, regulation; intracellular localization translation, altered; signaling pathway regulation; translation, inhibited SLC27A1(INDUCES); GAPDH(INDUCES); RPL13A(INDUCES); MARS(DISRUPTS); KARS(DISRUPTS); EEF1E1(DISRUPTS) 19647514; 23071094; 28178239; 36309524 7 4 0 regulates inflammatory downstream signaling pathways -SDC2 syndecan-2 Cell adhesion; Cell surface; Membrane protein, integral; Motility/polarity/chemotaxis P34741 6383 8q22.1 human S188-p 452069 LGERKPSsAAYQKAP Syndecan transcription, induced 28821612 2 3 1 MMP-7 expression in HT-29 colon cancer cells -GHR GH receptor Membrane protein, integral; Receptor, cytokine P19941 100009325 rabbit Y487-p 450479 SLANIDFyAQVSDIT GHBP molecular association, regulation SOCS2(INDUCES); CISH(INDUCES) 17666591 2 0 0 -Cryab CRYAB Chaperone; Heat shock protein P23928 25420 8q23 rat S59-p 448783 PSFLRAPsWIDTGLS protein degradation; intracellular localization; activity, inhibited; phosphorylation apoptosis, altered; cytoskeletal reorganization; signaling pathway regulation 12574148; 17993600; 22870022; 24159092; 33220080 46 22 0 localization of phosphorylated alpha-BCs in the diabetic retina; regulates the dentritic functions of HspB5 -Alyref2 Refbp2 DNA-binding; RNA-binding Q9JJW6 56009 1|1 H3 mouse R166-m2 13906413 RPAQSGNrGGMTRSR FoP_duplication molecular association, regulation RNA(DISRUPTS) 20129943 1 2 2 -G3BP1 G3BP-1 Adaptor/scaffold; EC 3.6.4.12; EC 3.6.4.13; Helicase; RNA-binding Q13283 10146 5q33.1 human R435-m1 6008955 LRGPGGPrGGLGGGM translation, altered 27601476 1 6 65 inhibits Stress Granules (SGs)-RNA granule assembly upon environmental stress -Lats1 LATS1 EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, AGC; Protein kinase, Ser/Thr (non-receptor); Tumor suppressor Q8BYR2 16798 10|10 A1 mouse Y277-p 484657 PSSQTKRySGNMEYV phosphorylation; enzymatic activity, induced cell growth, inhibited; transcription, induced; signaling pathway regulation 35394840 1 3 0 -Wnk4 WNK4 EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, Other; Protein kinase, Ser/Thr (non-receptor) Q80UE6 69847 11|11 D mouse K325-ub 15400441 DLGLATLkRASFAKS Pkinase protein degradation 23576762 1 4 1 regulates electrolyte homeostasis and involved in Pseudohypoaldosteronism type II (PHAII) pathogenesis -Camk2d CAMK2D EC 2.7.11.17; KINASE; Kinase, protein; Protein kinase, CAMK; Protein kinase, Ser/Thr (non-receptor) P15791 24246 2q42 rat T287-p 450982 SMMHRQEtVDCLKKF enzymatic activity, induced cell motility, altered 14761894 15 32 148 -MAD1L1 MAD1L1 Cell cycle regulation; Cytoskeletal Q9Y6D9 8379 7p22.3 human T624-p 334535804 RLKEVFQtKIQEFRK MAD molecular association, regulation cell cycle regulation Mad2(INDUCES) 29162720 1 0 0 -KAT5 Tip60 ACETYLTRANSFERASE; Acetyltransferase; EC 2.3.1.48; Nuclear receptor co-regulator; Nucleolus Q92993 10524 11q13.1 human T158-p 10800707 VEVVSPAtPVPSETA protein stabilization; acetylation; ubiquitination; intracellular localization; phosphorylation; enzymatic activity, induced carcinogenesis, inhibited; apoptosis, induced; cell growth, inhibited; transcription, induced; signaling pathway regulation 23685072; 25544752; 36280132 3 5 2 induces p53-PUMA; induces p53 acetylation; inhibits ubiquitination, induces acetylation of its substrates H4 and ATM and induces phosphorylation of itself at S199; increases acetylation of MAPKAPK5 at K364, oncogene-induced senescence -Itpr1 IP3R1 Channel, calcium; Channel, ligand-gated; Membrane protein, integral; Membrane protein, multi-pass P29994 25262 4q41 rat S2682-p 458310 FPRMRAMsLVSSDSE activity, inhibited 16332683 1 3 1 staurosporin-induced caspase-3 activation was enhanced in cells expressing S2682A mutant IP3R1. -JUN Jun Oncoprotein; Transcription factor P05412 3725 1p32.1 human K273-ac 458868 ASKCRKRkLERIARL bZIP_1 molecular association, regulation; phosphorylation carcinogenesis, induced; transcription, induced; transcription, inhibited; signaling pathway regulation DNA(INDUCES) 16214953; 27956703; 30987999 3 0 0 ERK phosphorylation-signaling inhibited ; AP-1 signaling pathway -Panx1 PANX1 Cell adhesion; Membrane protein, integral; Membrane protein, multi-pass P60570 315435 8q12 rat T302-p 1871464504 FVPFRQKtDVLKVYE activity, inhibited 33276429 1 0 0 inhibits mechanical stretch induced activation of Panx1 channels -Ccdc88a girdin Actin-binding Q5SNZ0 108686 11|11 A3.3 mouse S245-p 4725941 PGMKRTEsRQHLSVE signaling pathway regulation 33548500 1 2 0 regulates colon permeability; Regulates SPS pathway -Prkar2b PKAR2B Mitochondrial; Protein kinase, regulatory subunit P31324 19088 12|12 A3 mouse S112-p 452036 NRFTRRAsVCAEAYN enzymatic activity, inhibited; phosphorylation neural plasticity 33649504 5 69 173 inhibits CREB phosphorylation -TYMS TYMS Cofactor and Vitamin Metabolism - one carbon pool by folate; DNA repair, damage; EC 2.1.1.45; METHYLTRANSFERASE; Methyltransferase; Mitochondrial; Nucleotide Metabolism - pyrimidine P04818 7298 18p11.32 human S114-p 4701881 KIWDANGsRDFLDSL Thymidylat_synt phosphorylation 34845374 1 12 0 reciprocal phosphorylation/O-GlcNAcylation with T306 O-GlcAc site -MDM2 MDM2 EC 6.3.2.-; EC 6.3.2.19; Inhibitor; Ligase; NEDDYLATION LIGASE; Neddylation Ligase; Nucleolus; Oncoprotein; UBIQUITIN LIGASE; Ubiquitin conjugating system; Ubiquitin ligase Q00987 4193 12q15 human S429-p 11956707 KEESVESsLPLNAIE protein degradation; protein stabilization; molecular association, regulation; ubiquitination; enzymatic activity, inhibited; protein conformation MDM2(DISRUPTS); ubiquitin(INDUCES); UBE2D2(INDUCES); p53(DISRUPTS) 19816404; 21986495; 32350255 3 2 0 oligomerization inhibited; induces MDM2 autodegradation/ induces auto ubiquitination of MDM2; phospho-mimic mutant is defective for p53 poly-ubiquitination; enhancing p53 stabilization -NCOA3 SRC-3 ACETYLTRANSFERASE; Acetyltransferase; EC 2.3.1.48; Motility/polarity/chemotaxis; Nuclear receptor co-regulator; Transcription, coactivator/corepressor Q9Y6Q9 8202 20q13.12 human S505-p 454109 SPVAGVHsPMASSGN NCOA_u2 activity, induced; protein degradation; molecular association, regulation; ubiquitination carcinogenesis, induced; cell growth, induced; transcription, induced; signaling pathway regulation ER-alpha(DISRUPTS); ER-alpha(INDUCES) 15383283; 16760465; 17574025; 33542078 7 0 0 -BAD BAD Apoptosis Q92934 572 11q13.1 human S134-p 447864 KGLPRPKsAGTATQM Bcl-2_BAD carcinogenesis, induced; cell growth, induced; apoptosis, inhibited 17936702; 21317286 6 22 3 -Tek TIE2 EC 2.7.10.1; KINASE; Kinase, protein; Membrane protein, integral; Protein kinase, TK; Protein kinase, tyrosine (receptor) Q02858 21687 4 C5|4 43.34 cM mouse Y1111-p 450257 TLYEKFTyAGIDCSA enzymatic activity, inhibited; protein conformation; phosphorylation 20026268 3 0 0 Y1113F mutation increases TIE2 phosphorylation and enhances downstream signaling -PNPT1 PNPT1 EC 2.7.7.8; Mitochondrial; Nucleotide Metabolism - purine; Nucleotide Metabolism - pyrimidine; RNA-binding; Transferase Q8TCS8 87178 2p16.1 human S776-p 482067 IVMGEPIsQSSSNSQ enzymatic activity, inhibited carcinogenesis, induced; RNA stability, induced 22815474 1 2 0 suppresses RNAse activity and increases resistance of cancer cells to IR -EYA1 EYA1 Apoptosis; Cell development/differentiation; DNA repair, damage; EC 3.1.3.16; EC 3.1.3.48; Motility/polarity/chemotaxis; PHOSPHATASE; Protein phosphatase, tyrosine (non-receptor) Q99502 2138 8q13.3 human K147-sm 41156501 GALWAGIkTEGGLSQ transcription, inhibited 24954506 1 0 0 -Trp53 p53 iso2 Activator; DNA-binding; Motility/polarity/chemotaxis; Nuclear receptor co-regulator; Transcription factor; Tumor suppressor Q80ZA1 22059 11 B3|11 42.83 cM mouse K98-ac 59149204 SSFVPSQkTYQGNYG P53 carcinogenesis, inhibited; transcription, induced 27705786 2 1 0 -Drd1 DRD1 GPCR, family 1; Membrane protein, integral; Membrane protein, multi-pass; Receptor, GPCR P18901 24316 17p14 rat S431-p 458340 LDYDTDVsLEKIQPV receptor desensitization, altered; intracellular localization 16338988 2 0 0 -Rela NFkB-p65 DNA-binding; Nuclear receptor co-regulator; Transcription factor Q04207 19697 19 A|19 4.34 cM mouse K221-ac 459094 LLCDKVQkEDIEVYF RHD_dimer transcription, induced 17590163 12 0 0 -Sdha SDHA Carbohydrate Metabolism - citrate (TCA) cycle; EC 1.3.5.1; Energy Metabolism - oxidative phosphorylation; Mitochondrial; Oxidoreductase; Tumor suppressor Q8K2B3 66945 13|13 C1 mouse Y215-p 25682901 SLRYDTSyFVEYFAL FAD_binding_2 activity, induced; molecular association, regulation cell growth, induced 27883180 2 0 0 B cell activation -GATAD2B GATAD2B Transcription factor Q8WXI9 57459 1q21.3 human K33-sm 3755613 DVLAKRLkMEGHEAM molecular association, regulation transcription, inhibited RBBP7(INDUCES) 16738318 1 0 0 -Shc1 SHC1 Adaptor/scaffold; Apoptosis; Mitochondrial; Motility/polarity/chemotaxis P98083 20416 3 F1|3 39.11 cM mouse Y350-p 448510 EPPDHQYyNDFPGKE activity, induced; molecular association, regulation; phosphorylation cell differentiation, altered; cell growth, induced GRB2(INDUCES) 11713219; 12101399; 14576154; 15930121; 24837366 29 22 943 Shc3F breast tumor growth was significantly delayed, and display a significant increase in VEGF protein -Mst1r Ron EC 2.7.10.1; KINASE; Kinase, protein; Membrane protein, integral; Protein kinase, TK; Protein kinase, tyrosine (receptor) Q62190 19882 9 59.07 cM|9 F1 mouse Y1337-p 456488 YVQLTAAyVNVGPRA enzymatic activity, induced apoptosis, induced; cell growth, altered GRB2(INDUCES); PLCG1(INDUCES); SHC1(INDUCES); PIK3CA(INDUCES) 16103119; 8918464 5 0 0 -SOS1 SOS1 Adaptor/scaffold; GEF; GEF, Ras; Motility/polarity/chemotaxis Q07889 6654 2p22.1 human S1167-p 451314 ESAPAESsPSKIMSK molecular association, regulation GRB2(DISRUPTS) 8816480 2 3 1 -Plk4 PLK4 EC 2.7.11.21; KINASE; Kinase, protein; Nucleolus; Protein kinase, Other; Protein kinase, Ser/Thr (non-receptor) Q64702 20873 3|3 B mouse T292-p 12654007 SGHATLStTITASSG protein degradation; ubiquitination 20100909 2 1 0 -DRD1 DRD1 GPCR, family 1; Membrane protein, integral; Membrane protein, multi-pass; Receptor, GPCR P21728 1812 5q35.2 human S263-p 1869357203 PESSFKMsFKRETKV 7tm_1 signaling pathway regulation 32503917 1 0 0 ERK1/2 and Src activation -CD247 CD3Z Membrane protein, integral; Receptor, misc. P20963 919 1q24.2 human Y111-p 448933 KNPQEGLyNELQKDK ITAM intracellular localization carcinogenesis, inhibited; signaling pathway regulation 18760640; 30131370 3 19 399 -Map4 MAP4 Cytoskeletal; Motility/polarity/chemotaxis P27546 17758 9 F2|9 59.83 cM mouse S914-p 1210622 SVRSKVGsTENIKHQ Tubulin-binding cytoskeletal reorganization 23316058; 34040253 4 53 41 regulates Microtubule stability; regulates microtubule detyrosination -EGFR EGFR EC 2.7.10.1; KINASE; Kinase, protein; Membrane protein, integral; Oncoprotein; Protein kinase, TK; Protein kinase, tyrosine (receptor) P00533 1956 7p11.2 human K1188-ub 27187786 AKPNGIFkGSTAENA protein stabilization 32669362 1 3 0 SMURF2-UBE2D1 protein?protein interaction affects mutant EGFR levels -MATR3 matrin 3 RNA processing; RNA-binding P43243 9782 5q31.2 human S208-p 452690 DYDHGSRsQESGYYD intracellular localization cell differentiation, inhibited; cell growth, induced 30194346 1 33 8 -AKT1 Akt1 EC 2.7.11.1; KINASE; Kinase, protein; Oncoprotein; Protein kinase, AGC; Protein kinase, Ser/Thr (non-receptor) P31749 207 14q32.33 human T308-p 447856 KDGATMKtFCGTPEY Pkinase receptor desensitization, induced; protein degradation; molecular association, regulation; phosphorylation; enzymatic activity, induced; activity, induced; sumoylation; ubiquitination; intracellular localization; protein conformation cell cycle regulation; apoptosis, altered; carcinogenesis, induced; apoptosis, induced; cell motility, induced; cell motility, inhibited; signaling pathway regulation; cell growth, induced; cell motility, altered; transcription, inhibited; cell growth, altered; cell differentiation, inhibited; carcinogenesis, inhibited; cell growth, inhibited; transcription, induced; transcription, altered; neural plasticity; DNA repair, induced; apoptosis, inhibited; autophagy, inhibited; cytoskeletal reorganization NPM1(INDUCES); TRIL(INDUCES); PDK1(INDUCES); PAK1(INDUCES); PPP2CA(INDUCES); MLLT11(INDUCES); TGFBR3(INDUCES); TRAF6(INDUCES) 10400692; 10713677; 10926925; 10958682; 11006271; 11020382; 11319202; 11358816; 11389054; 11978735; 12138162; 12556562; 12609989; 12970779; 14623889; 14713298; 15065872; 15327518; 15504738; 16044149; 17928291; 18042541; 18678787; 18931307; 18931661; 19609947; 19996208; 20153512; 20303298; 20371716; 20643654; 21159648; 21329883; 21394080; 21577208; 21750219; 21775285; 21908616; 23142783; 23188060; 23901139; 24297901; 24446434; 24632852; 24634221; 25538243; 25867063; 26235620; 26411369; 28462918; 28676490; 30413706; 33592378; 33723214; 33727226; 33730574; 33793628; 33874915; 33984593; 33993653; 34078530; 34080025; 34194551; 34209868; 34226680; 34273354; 34288124; 34301793; 34385319; 34418433; 34503444; 34551282; 34604061; 34611309; 34675073; 34675258; 34686341; 34909046; 34921839; 34925032; 34938598; 34948236; 34995286; 35061720; 35077510; 35214753; 35216969; 35253622; 35366279; 35413055; 35545051; 35577075; 35810308; 35835217; 35864174; 35918763; 35998013; 36106050; 36174454; 36413544; 36640312; 36658650; 37078777; 37430297; 37507012; 8978681; 9228007; 9445477; 9690513 802 14 18 -PRKCB PKCB EC 2.7.11.13; KINASE; Kinase, protein; Motility/polarity/chemotaxis; Protein kinase, AGC; Protein kinase, Ser/Thr (non-receptor) P05771 5579 16p12.2-p12.1 human T500-p 447896 WDGVTTKtFCGTPDY Pkinase molecular association, regulation; ubiquitination; intracellular localization; phosphorylation; enzymatic activity, induced endocytosis, induced RICTOR(INDUCES); ACTA1(INDUCES); CLTA(INDUCES) 36717249 10 47 44 primes phosphorylation of T642 -CTTN Cortactin Actin-binding; Cytoskeletal; Motility/polarity/chemotaxis Q14247 2017 11q13.3 human K198-ac 461720 YSKGFGGkYGIDKDK HS1_rep molecular association, regulation; intracellular localization cell motility, inhibited ACTB(DISRUPTS) 17643370 1 4 3 Acetylation prevents localization to membrane ruf?es. -FOXA2 FOXA2 DNA-binding; Transcription factor Q9Y261 3170 20p11.21 human K264-ac 9915006 CEKQLALkEAAGAAG protein stabilization transcription, induced 24875183 1 1 1 -ITGB4 ITGB4 Cell adhesion; Membrane protein, integral; Motility/polarity/chemotaxis; Receptor, misc. P16144 3691 17q25.1 human S1494-p 465821 TLTRDYNsLTRSEHS intracellular localization 19005215 2 14 31 inhibits incorporation of ITGB4 into hemidesmosomes and promotes its disassembly -Rps3 RPS3 Apoptosis; EC 4.2.99.18; RNA-binding; Ribosomal; Translation P62908 27050 7 E1|7 54.07 cM mouse T70-p 15113600 GRRIRELtAVVQKRF KH_2 protein stabilization; molecular association, regulation; ubiquitination chromatin organization, altered; apoptosis, inhibited CHIP(DISRUPTS); HSP70(DISRUPTS) 30213050 3 2 0 phosphorylated T70 induces stability, condensed chromatin -Hdac5 HDAC5 DEACETYLASE; Deacetylase; EC 3.5.1.98; Hydrolase F1LM64 84580 10q32.1 rat S83-p 447995 FPLRKTAsEPNLKVR protein stabilization; intracellular localization transcription, induced 26647181; 35704695 25 23 25 -RICTOR RICTOR Adaptor/scaffold; Cell cycle regulation; Ubiquitin conjugating system Q6R327 253260 5p13.1 human K1125-ac 41692101 GKLSSESkTSNRRIR RICTOR_phospho signaling pathway regulation 26170313 1 0 0 induces mTORC2 signaling -Kcnb2 Kv2.2 Channel, potassium; Membrane protein, integral; Membrane protein, multi-pass Q63099 117105 5q11 rat S488-p 15721000 SVDDNHLsPSRWKWA Kv2channel activity, inhibited neural plasticity 34542799 1 3 0 -FOXP3 FOXP3 C2H2-type zinc finger protein; Cell cycle regulation; DNA-binding; Transcription factor Q9BZS1 50943 Xp11.23 human Y342-p 29606712 NMRPPFTyATLIRWA Forkhead activity, induced carcinogenesis, inhibited; transcription, induced; transcription, inhibited 24155921; 30011797; 34768829 3 0 0 -SRC Src EC 2.7.10.2; KINASE; Kinase, protein; Oncoprotein; Protein kinase, TK; Protein kinase, tyrosine (non-receptor) P00523 396442 chicken Y519-p 7445100 LQAFLEDyFTSTEPQ cell growth, altered 3103926 8 0 0 From 00851ae903141d572c83b1615effff6c5db66666 Mon Sep 17 00:00:00 2001 From: Eirinits Date: Thu, 4 Apr 2024 11:17:42 +0200 Subject: [PATCH 04/10] update read_csv function for psp data --- omniflow_project/_inputs/resources.py | 4 ++-- 1 file changed, 2 insertions(+), 2 deletions(-) diff --git a/omniflow_project/_inputs/resources.py b/omniflow_project/_inputs/resources.py index bc461e6..27794c5 100644 --- a/omniflow_project/_inputs/resources.py +++ b/omniflow_project/_inputs/resources.py @@ -118,8 +118,8 @@ def process_psp_interactions(self, kinase_int_file, phospho_effect_file, organis Loads files from PhoshpositePlus (PSP), parses the files to create sign interactions based on the effect of phosphorylation on protein activities and creates an interaction dataframe based on the Omnipath interaction format. """ - kinase_int = pd.read_csv(kinase_int_file) - phospho_effect = pd.read_csv(phospho_effect_file) + kinase_int = pd.read_csv(kinase_int_file, sep = "\t") + phospho_effect = pd.read_csv(phospho_effect_file, sep = "\t") # Filter kinase_int dataframe to include only interactions from specified organisms kinase_int_filtered = kinase_int.loc[(kinase_int['KIN_ORGANISM'] == organism) & (kinase_int['SUB_ORGANISM'] == organism)] From 3b06bbfd447f88fb0950b27ffc402774695b0049 Mon Sep 17 00:00:00 2001 From: Eirinits Date: Thu, 4 Apr 2024 11:49:54 +0200 Subject: [PATCH 05/10] Tutorial: Add resources --- ...xpanding existing network-checkpoint.ipynb | 6 + .../.ipynb_checkpoints/Mouse-checkpoint.ipynb | 6 + .../add_resources-checkpoint.ipynb | 9936 +++++++++++++++++ ...build_phosphosite_network-checkpoint.ipynb | 441 + .../network_building-checkpoint.ipynb | 9918 ++++++++++++++++ .../ontology-checkpoint.ipynb | 9451 ++++++++++++++++ .../tissue_mapping-checkpoint.ipynb | 986 ++ notebooks/add_resources.ipynb | 2948 +++++ 8 files changed, 33692 insertions(+) create mode 100644 notebooks/.ipynb_checkpoints/Expanding existing network-checkpoint.ipynb create mode 100644 notebooks/.ipynb_checkpoints/Mouse-checkpoint.ipynb create mode 100644 notebooks/.ipynb_checkpoints/add_resources-checkpoint.ipynb create mode 100644 notebooks/.ipynb_checkpoints/build_phosphosite_network-checkpoint.ipynb create mode 100644 notebooks/.ipynb_checkpoints/network_building-checkpoint.ipynb create mode 100644 notebooks/.ipynb_checkpoints/ontology-checkpoint.ipynb create mode 100644 notebooks/.ipynb_checkpoints/tissue_mapping-checkpoint.ipynb create mode 100644 notebooks/add_resources.ipynb diff --git a/notebooks/.ipynb_checkpoints/Expanding existing network-checkpoint.ipynb b/notebooks/.ipynb_checkpoints/Expanding existing network-checkpoint.ipynb new file mode 100644 index 0000000..363fcab --- /dev/null +++ b/notebooks/.ipynb_checkpoints/Expanding existing network-checkpoint.ipynb @@ -0,0 +1,6 @@ +{ + "cells": [], + "metadata": {}, + "nbformat": 4, + "nbformat_minor": 5 +} diff --git a/notebooks/.ipynb_checkpoints/Mouse-checkpoint.ipynb b/notebooks/.ipynb_checkpoints/Mouse-checkpoint.ipynb new file mode 100644 index 0000000..363fcab --- /dev/null +++ b/notebooks/.ipynb_checkpoints/Mouse-checkpoint.ipynb @@ -0,0 +1,6 @@ +{ + "cells": [], + "metadata": {}, + "nbformat": 4, + "nbformat_minor": 5 +} diff --git a/notebooks/.ipynb_checkpoints/add_resources-checkpoint.ipynb b/notebooks/.ipynb_checkpoints/add_resources-checkpoint.ipynb new file mode 100644 index 0000000..aafceb5 --- /dev/null +++ b/notebooks/.ipynb_checkpoints/add_resources-checkpoint.ipynb @@ -0,0 +1,9936 @@ +{ + "cells": [ + { + "cell_type": "markdown", + "id": "55b5595c-fec9-41c3-b756-b95cd0c52048", + "metadata": {}, + "source": [ + "## Add resources\n", + "\n", + "This notebook explores how to add other individual resources from Omnipath or other public databased." + ] + }, + { + "cell_type": "code", + "execution_count": 2, + "id": "3c317de8", + "metadata": {}, + "outputs": [ + { + "name": "stderr", + "output_type": "stream", + "text": [ + "/home/eirini/anaconda3/envs/omniflow_env/lib/python3.10/site-packages/tqdm/auto.py:21: TqdmWarning: IProgress not found. Please update jupyter and ipywidgets. See https://ipywidgets.readthedocs.io/en/stable/user_install.html\n", + " from .autonotebook import tqdm as notebook_tqdm\n" + ] + }, + { + "ename": "ModuleNotFoundError", + "evalue": "No module named 'omniflow_project._annotations'", + "output_type": "error", + "traceback": [ + "\u001b[0;31m---------------------------------------------------------------------------\u001b[0m", + "\u001b[0;31mModuleNotFoundError\u001b[0m Traceback (most recent call last)", + "File \u001b[0;32m:4\u001b[0m\n", + "\u001b[0;31mModuleNotFoundError\u001b[0m: No module named 'omniflow_project._annotations'" + ] + } + ], + "source": [ + "%%time\n", + "from omniflow_project.core.network import Network\n", + "from omniflow_project._visual.visualize_network import NetworkVisualizer\n", + "from omniflow_project._inputs.resources import Resources\n", + "from omniflow_project._annotations.gene_ontology import Ontology\n", + "import omnipath as op" + ] + }, + { + "cell_type": "markdown", + "id": "2a250d98", + "metadata": {}, + "source": [ + "### If the all_interaction database of omnipath is not sufficient, we can change it or extend it. \n", + "\n" + ] + }, + { + "cell_type": "markdown", + "id": "e5a3b471-0e53-47b6-a986-95e278b94ece", + "metadata": {}, + "source": [ + "#### 1. Get all interactions from OmniPath" + ] + }, + { + "cell_type": "code", + "execution_count": 10, + "id": "794f4de1", + "metadata": {}, + "outputs": [], + "source": [ + "interactions = op.interactions.AllInteractions.get() " + ] + }, + { + "cell_type": "markdown", + "id": "aeec437c", + "metadata": {}, + "source": [ + "#### 2. Add all interactions in the Resources object" + ] + }, + { + "cell_type": "code", + "execution_count": 11, + "id": "d45b7920", + "metadata": {}, + "outputs": [], + "source": [ + "resources = Resources()\n", + "resources.add_database(interactions)" + ] + }, + { + "cell_type": "code", + "execution_count": 12, + "id": "8dfed589", + "metadata": {}, + "outputs": [ + { + "data": { + "text/html": [ + "
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0P0DP23P48995TrueFalseTrueTrueFalseTrue3TRIP:11290752;TRIP:11983166;TRIP:12601176TRIPpost_translational11311290752;11983166;12601176
1P0DP25P48995TrueFalseTrueTrueFalseTrue3TRIP:11290752;TRIP:11983166;TRIP:12601176TRIPpost_translational11311290752;11983166;12601176
2P0DP24P48995TrueFalseTrueTrueFalseTrue3TRIP:11290752;TRIP:11983166;TRIP:12601176TRIPpost_translational11311290752;11983166;12601176
3Q03135P48995TrueTrueFalseTrueTrueFalse13DIP:19897728;HPRD:12732636;IntAct:19897728;Lit...DIP;HPRD;IntAct;Lit-BM-17;TRIPpost_translational55810980191;12732636;14551243;16822931;18430726;1...
4P14416P48995TrueTrueFalseTrueTrueFalse1TRIP:18261457TRIPpost_translational11118261457
...................................................
276174439260P35348TrueFalseFalseFalseFalseFalse3Cellinker:10433504;Cellinker:7651358;Cellinker...Cellinker;Guide2Pharma_Cellinkersmall_molecule_protein21310433504;7651358;8564227
2761755202Q13639TrueFalseFalseFalseFalseFalse10Cellinker:10646498;Cellinker:10683202;Cellinke...Cellinker;Guide2Pharma_Cellinkersmall_molecule_protein211010646498;10683202;10821780;11030734;11218067;1...
2761766305Q6DWJ6TrueFalseFalseFalseFalseFalse1Cellinker:26349500Cellinker;Guide2Pharma_Cellinkersmall_molecule_protein21126349500
276177643961Q9GZU1TrueFalseFalseFalseFalseFalse1Cellinker:20802798Cellinker;Guide2Pharma_Cellinkersmall_molecule_protein21120802798
276178448457Q13258TrueFalseFalseFalseFalseFalse4Cellinker:10448933;Cellinker:16604093;Cellinke...Cellinker;Guide2Pharma_Cellinkersmall_molecule_protein21410448933;16604093;7642548;9579725
\n", + "

276179 rows × 16 columns

\n", + "
" + ], + "text/plain": [ + " source target is_directed is_stimulation is_inhibition \\\n", + "0 P0DP23 P48995 True False True \n", + "1 P0DP25 P48995 True False True \n", + "2 P0DP24 P48995 True False True \n", + "3 Q03135 P48995 True True False \n", + "4 P14416 P48995 True True False \n", + "... ... ... ... ... ... \n", + "276174 439260 P35348 True False False \n", + "276175 5202 Q13639 True False False \n", + "276176 6305 Q6DWJ6 True False False \n", + "276177 643961 Q9GZU1 True False False \n", + "276178 448457 Q13258 True False False \n", + "\n", + " consensus_direction consensus_stimulation consensus_inhibition \\\n", + "0 True False True \n", + "1 True False True \n", + "2 True False True \n", + "3 True True False \n", + "4 True True False \n", + "... ... ... ... \n", + "276174 False False False \n", + "276175 False False False \n", + "276176 False False False \n", + "276177 False False False \n", + "276178 False False False \n", + "\n", + " curation_effort references \\\n", + "0 3 TRIP:11290752;TRIP:11983166;TRIP:12601176 \n", + "1 3 TRIP:11290752;TRIP:11983166;TRIP:12601176 \n", + "2 3 TRIP:11290752;TRIP:11983166;TRIP:12601176 \n", + "3 13 DIP:19897728;HPRD:12732636;IntAct:19897728;Lit... \n", + "4 1 TRIP:18261457 \n", + "... ... ... \n", + "276174 3 Cellinker:10433504;Cellinker:7651358;Cellinker... \n", + "276175 10 Cellinker:10646498;Cellinker:10683202;Cellinke... \n", + "276176 1 Cellinker:26349500 \n", + "276177 1 Cellinker:20802798 \n", + "276178 4 Cellinker:10448933;Cellinker:16604093;Cellinke... \n", + "\n", + " sources type n_sources \\\n", + "0 TRIP post_translational 1 \n", + "1 TRIP post_translational 1 \n", + "2 TRIP post_translational 1 \n", + "3 DIP;HPRD;IntAct;Lit-BM-17;TRIP post_translational 5 \n", + "4 TRIP post_translational 1 \n", + "... ... ... ... \n", + "276174 Cellinker;Guide2Pharma_Cellinker small_molecule_protein 2 \n", + "276175 Cellinker;Guide2Pharma_Cellinker small_molecule_protein 2 \n", + "276176 Cellinker;Guide2Pharma_Cellinker small_molecule_protein 2 \n", + "276177 Cellinker;Guide2Pharma_Cellinker small_molecule_protein 2 \n", + "276178 Cellinker;Guide2Pharma_Cellinker small_molecule_protein 2 \n", + "\n", + " n_primary_sources n_references \\\n", + "0 1 3 \n", + "1 1 3 \n", + "2 1 3 \n", + "3 5 8 \n", + "4 1 1 \n", + "... ... ... \n", + "276174 1 3 \n", + "276175 1 10 \n", + "276176 1 1 \n", + "276177 1 1 \n", + "276178 1 4 \n", + "\n", + " references_stripped \n", + "0 11290752;11983166;12601176 \n", + "1 11290752;11983166;12601176 \n", + "2 11290752;11983166;12601176 \n", + "3 10980191;12732636;14551243;16822931;18430726;1... \n", + "4 18261457 \n", + "... ... \n", + "276174 10433504;7651358;8564227 \n", + "276175 10646498;10683202;10821780;11030734;11218067;1... \n", + "276176 26349500 \n", + "276177 20802798 \n", + "276178 10448933;16604093;7642548;9579725 \n", + "\n", + "[276179 rows x 16 columns]" + ] + }, + "execution_count": 12, + "metadata": {}, + "output_type": "execute_result" + } + ], + "source": [ + "resources.interactions" + ] + }, + { + "cell_type": "markdown", + "id": "d3dca809", + "metadata": {}, + "source": [ + "#### 3. Add interactions from a specific resource. " + ] + }, + { + "cell_type": "markdown", + "id": "0e6b2c56-80cd-459b-984a-fa235c1a0085", + "metadata": {}, + "source": [ + "#### 3A. Specify the interaction resource of interest" + ] + }, + { + "cell_type": "code", + "execution_count": 13, + "id": "829de33a", + "metadata": {}, + "outputs": [], + "source": [ + "extra = op.interactions.LigRecExtra.get()" + ] + }, + { + "cell_type": "markdown", + "id": "fc585a3c", + "metadata": {}, + "source": [ + "#### 3B. Add new resource to the Resources object" + ] + }, + { + "cell_type": "code", + "execution_count": 14, + "id": "91ae2cef", + "metadata": {}, + "outputs": [], + "source": [ + "resources.add_database(extra, reset_index=True)" + ] + }, + { + "cell_type": "markdown", + "id": "8fe2700c-5b59-4302-9a9e-cc2de59d34af", + "metadata": {}, + "source": [ + "### 4. Build the network" + ] + }, + { + "cell_type": "code", + "execution_count": 3, + "id": "79c09e13", + "metadata": {}, + "outputs": [], + "source": [ + "genes = [\"SRC\", \"NOTCH1\", \"FAK\", \"CDH1\", \"CDH2\", \"VIM\", \"MAP4K4\", \"LATS1\", \"LATS2\", \"PTK2B\"]" + ] + }, + { + "cell_type": "markdown", + "id": "6a5b5adf", + "metadata": {}, + "source": [ + "### 2. Create a network using as input the gene set. \n", + "\n" + ] + }, + { + "cell_type": "markdown", + "id": "2910c871-fdfc-4d20-b76f-af213f06a3f0", + "metadata": {}, + "source": [ + "#### 2A. Import genes as network nodes" + ] + }, + { + "cell_type": "code", + "execution_count": 3, + "id": "fcf68a99-8454-41e3-8816-c3f976d04c0b", + "metadata": {}, + "outputs": [ + { + "name": "stdout", + "output_type": "stream", + "text": [ + "Loading deafault omnipath all interactions\n" + ] + } + ], + "source": [ + "new_net1 = Network(genes)" + ] + }, + { + "cell_type": "code", + "execution_count": 4, + "id": "fad00bec-ba72-4943-bf1e-9c60f58f17a2", + "metadata": {}, + "outputs": [ + { + "ename": "NameError", + "evalue": "name 'new_net1' is not defined", + "output_type": "error", + "traceback": [ + "\u001b[0;31m---------------------------------------------------------------------------\u001b[0m", + "\u001b[0;31mNameError\u001b[0m Traceback (most recent call last)", + "Cell \u001b[0;32mIn[4], line 2\u001b[0m\n\u001b[1;32m 1\u001b[0m \u001b[38;5;66;03m#Print node dataframe\u001b[39;00m\n\u001b[0;32m----> 2\u001b[0m \u001b[43mnew_net1\u001b[49m\u001b[38;5;241m.\u001b[39mnodes\n", + "\u001b[0;31mNameError\u001b[0m: name 'new_net1' is not defined" + ] + } + ], + "source": [ + "#Print node dataframe\n", + "new_net1.nodes" + ] + }, + { + "cell_type": "markdown", + "id": "a2759581", + "metadata": {}, + "source": [ + "#### 2B. Explore if the nodes are connected without introducing new intermidiate nodes" + ] + }, + { + "cell_type": "code", + "execution_count": 5, + "id": "a339705b", + "metadata": {}, + "outputs": [ + { + "name": "stdout", + "output_type": "stream", + "text": [ + "P12931 Q05397\n", + "P12931 P19022\n", + "P12931 Q14289\n", + "Q14289 Q05397\n", + "CPU times: user 496 ms, sys: 0 ns, total: 496 ms\n", + "Wall time: 495 ms\n" + ] + } + ], + "source": [ + "%%time\n", + "new_net1.connect_nodes(only_signed=True, consensus_only=True)" + ] + }, + { + "cell_type": "markdown", + "id": "2fb5674d", + "metadata": {}, + "source": [ + "#### 2C. Visualize the network with the following command. \n", + "\n", + "The network picture is also exported in the working repository, in pdf format." + ] + }, + { + "cell_type": "code", + "execution_count": 7, + "id": "db39112a", + "metadata": {}, + "outputs": [ + { + "data": { + "image/svg+xml": [ + "\n", + "\n", + "\n", + "\n", + "\n", + "\n", + "%3\n", + "\n", + "\n", + "\n", + "SRC\n", + "\n", + "SRC\n", + "\n", + "\n", + "\n", + "PTK2\n", + "\n", + "PTK2\n", + "\n", + "\n", + "\n", + "SRC->PTK2\n", + "\n", + "\n", + "\n", + "\n", + "\n", + "CDH2\n", + "\n", + "CDH2\n", + "\n", + "\n", + "\n", + "SRC->CDH2\n", + "\n", + "\n", + "\n", + "\n", + "\n", + "\n", + "PTK2B\n", + "\n", + "PTK2B\n", + "\n", + "\n", + "\n", + "SRC->PTK2B\n", + "\n", + "\n", + "\n", + "\n", + "\n", + "PTK2B->PTK2\n", + "\n", + "\n", + "\n", + "\n", + "\n", + "NOTCH1\n", + "\n", + "NOTCH1\n", + "\n", + "\n", + "\n", + "CDH1\n", + "\n", + "CDH1\n", + "\n", + "\n", + "\n", + "VIM\n", + "\n", + "VIM\n", + "\n", + "\n", + "\n", + "MAP4K4\n", + "\n", + "MAP4K4\n", + "\n", + "\n", + "\n", + "LATS1\n", + "\n", + "LATS1\n", + "\n", + "\n", + "\n", + "LATS2\n", + "\n", + "LATS2\n", + "\n", + "\n", + "\n" + ], + "text/plain": [ + "" + ] + }, + "metadata": {}, + "output_type": "display_data" + } + ], + "source": [ + "visualizer = NetworkVisualizer(new_net1, color_by='effect')\n", + "visualizer.render(output_file=\"new_network\")" + ] + }, + { + "cell_type": "markdown", + "id": "3c1725cc-4c08-4a85-b26c-8f59936e351d", + "metadata": {}, + "source": [ + "#### 2D. Connect disconnected nodes by importing intermediate nodes.\n", + "\n", + "The parameter _*maxlen*_ is used to verify that in the network all the nodes have a distance < than maxlen. \n", + "\n", + "The parameter _*only_signed*_ forces the algorithm to look for just signed interactions. \n", + "\n", + "The parameter _*consensus*_ retrieves those interactions with a sign consensus between the references. \n", + "\n", + "The parameter _*connect_node_when_first_introduced*_, changes the base algorithm, making it look for possible connection between all the disconnected node in the network when a new bridge-gene is introduced in the network." + ] + }, + { + "cell_type": "code", + "execution_count": 8, + "id": "9a07d77b", + "metadata": {}, + "outputs": [ + { + "name": "stdout", + "output_type": "stream", + "text": [ + "looking for paths in the network with length: 0 for node SRC and NOTCH1\n", + "looking for paths in the network with length: 1 for node SRC and NOTCH1\n", + "looking for paths in the network with length: 2 for node SRC and NOTCH1\n", + "looking for paths in the network with length: 3 for node SRC and NOTCH1\n", + "looking for paths in the network with length: 4 for node SRC and NOTCH1\n", + "looking for paths in the network with length: 5 for node SRC and NOTCH1\n", + "looking for paths in the network with length: 6 for node SRC and NOTCH1\n", + "i_search = 3\n", + "Looking for paths with length: 0 for node SRC and NOTCH1\n", + "i_search = 3\n", + "Looking for paths with length: 1 for node SRC and NOTCH1\n", + "i_search = 3\n", + "Looking for paths with length: 2 for node SRC and NOTCH1\n", + "[['SRC', 'CTNNB1', 'NOTCH1'], ['SRC', 'DAB1', 'NOTCH1']]\n", + "P12931 P35222\n", + "P35222 P46531\n", + "P12931 O75553\n", + "O75553 P46531\n", + "P12931 Q05397\n", + "P12931 P19022\n", + "P12931 Q14289\n", + "P12931 P35222\n", + "P12931 O75553\n", + "P35222 P46531\n", + "O75553 P46531\n", + "Q14289 Q05397\n", + "P12830 P35222\n", + "P19022 P35222\n", + "looking for paths in the network with length: 0 for node SRC and PTK2\n", + "looking for paths in the network with length: 1 for node SRC and PTK2\n", + "Found a path!\n", + "[['SRC', 'PTK2']]\n", + "looking for paths in the network with length: 0 for node SRC and CDH1\n", + "looking for paths in the network with length: 1 for node SRC and CDH1\n", + "looking for paths in the network with length: 2 for node SRC and CDH1\n", + "looking for paths in the network with length: 3 for node SRC and CDH1\n", + "looking for paths in the network with length: 4 for node SRC and CDH1\n", + "looking for paths in the network with length: 5 for node SRC and CDH1\n", + "looking for paths in the network with length: 6 for node SRC and CDH1\n", + "i_search = 3\n", + "Looking for paths with length: 0 for node SRC and CDH1\n", + "i_search = 3\n", + "Looking for paths with length: 1 for node SRC and CDH1\n", + "i_search = 3\n", + "Looking for paths with length: 2 for node SRC and CDH1\n", + "[['SRC', 'MET', 'CDH1'], ['SRC', 'PRKD1', 'CDH1'], ['SRC', 'CTNND1', 'CDH1']]\n", + "P12931 P08581\n", + "P08581 P12830\n", + "P12931 Q15139\n", + "Q15139 P12830\n", + "P12931 O60716\n", + "O60716 P12830\n", + "P12931 Q05397\n", + "P12931 P19022\n", + "P12931 Q14289\n", + "P12931 P35222\n", + "P12931 O75553\n", + "P12931 P08581\n", + "P12931 Q15139\n", + "P12931 O60716\n", + "P35222 P46531\n", + "O75553 P46531\n", + "Q14289 Q05397\n", + "P08581 Q05397\n", + "P12830 P35222\n", + "P08581 P12830\n", + "Q15139 P12830\n", + "O60716 P12830\n", + "P19022 P35222\n", + "O60716 P19022\n", + "Q15139 P35222\n", + "looking for paths in the network with length: 0 for node SRC and CDH2\n", + "looking for paths in the network with length: 1 for node SRC and CDH2\n", + "Found a path!\n", + "[['SRC', 'CDH2']]\n", + "looking for paths in the network with length: 0 for node SRC and VIM\n", + "looking for paths in the network with length: 1 for node SRC and VIM\n", + "looking for paths in the network with length: 2 for node SRC and VIM\n", + "looking for paths in the network with length: 3 for node SRC and VIM\n", + "looking for paths in the network with length: 4 for node SRC and VIM\n", + "looking for paths in the network with length: 5 for node SRC and VIM\n", + "looking for paths in the network with length: 6 for node SRC and VIM\n", + "i_search = 3\n", + "Looking for paths with length: 0 for node SRC and VIM\n", + "i_search = 3\n", + "Looking for paths with length: 1 for node SRC and VIM\n", + "i_search = 3\n", + "Looking for paths with length: 2 for node SRC and VIM\n", + "[['SRC', 'PAK2', 'VIM']]\n", + "P12931 Q13177\n", + "Q13177 P08670\n", + "P12931 Q05397\n", + "P12931 P19022\n", + "P12931 Q14289\n", + "P12931 P35222\n", + "P12931 O75553\n", + "P12931 P08581\n", + "P12931 Q15139\n", + "P12931 O60716\n", + "P12931 Q13177\n", + "P35222 P46531\n", + "O75553 P46531\n", + "Q14289 Q05397\n", + "P08581 Q05397\n", + "P12830 P35222\n", + "P08581 P12830\n", + "Q15139 P12830\n", + "O60716 P12830\n", + "P19022 P35222\n", + "O60716 P19022\n", + "Q13177 P08670\n", + "Q15139 P35222\n", + "looking for paths in the network with length: 0 for node SRC and MAP4K4\n", + "looking for paths in the network with length: 1 for node SRC and MAP4K4\n", + "looking for paths in the network with length: 2 for node SRC and MAP4K4\n", + "looking for paths in the network with length: 3 for node SRC and MAP4K4\n", + "looking for paths in the network with length: 4 for node SRC and MAP4K4\n", + "looking for paths in the network with length: 5 for node SRC and MAP4K4\n", + "looking for paths in the network with length: 6 for node SRC and MAP4K4\n", + "i_search = 3\n", + "Looking for paths with length: 0 for node SRC and MAP4K4\n", + "i_search = 3\n", + "Looking for paths with length: 1 for node SRC and MAP4K4\n", + "i_search = 3\n", + "Looking for paths with length: 2 for node SRC and MAP4K4\n", + "i_search = 3\n", + "Looking for paths with length: 3 for node SRC and MAP4K4\n", + "[['SRC', 'MAPK8', 'MAP3K7', 'MAP4K4'], ['SRC', 'MAPK8', 'MAP3K1', 'MAP4K4']]\n", + "P45983 P12931\n", + "O43318 P45983\n", + "O95819 O43318\n", + "P45983 P12931\n", + "Q13233 P45983\n", + "O95819 Q13233\n", + "P12931 Q05397\n", + "P12931 P19022\n", + "P12931 Q14289\n", + "P12931 P35222\n", + "P12931 O75553\n", + "P12931 P08581\n", + "P12931 Q15139\n", + "P12931 O60716\n", + "P12931 Q13177\n", + "P45983 P12931\n", + "P35222 P46531\n", + "O75553 P46531\n", + "Q14289 Q05397\n", + "P08581 Q05397\n", + "P12830 P35222\n", + "P08581 P12830\n", + "Q15139 P12830\n", + "O60716 P12830\n", + "P19022 P35222\n", + "O60716 P19022\n", + "Q13177 P08670\n", + "O95819 O43318\n", + "O95819 Q13233\n", + "Q15139 P35222\n", + "O43318 P45983\n", + "Q13233 P45983\n", + "looking for paths in the network with length: 0 for node SRC and LATS1\n", + "looking for paths in the network with length: 1 for node SRC and LATS1\n", + "looking for paths in the network with length: 2 for node SRC and LATS1\n", + "looking for paths in the network with length: 3 for node SRC and LATS1\n", + "looking for paths in the network with length: 4 for node SRC and LATS1\n", + "looking for paths in the network with length: 5 for node SRC and LATS1\n", + "looking for paths in the network with length: 6 for node SRC and LATS1\n", + "i_search = 3\n", + "Looking for paths with length: 0 for node SRC and LATS1\n", + "i_search = 3\n", + "Looking for paths with length: 1 for node SRC and LATS1\n", + "i_search = 3\n", + "Looking for paths with length: 2 for node SRC and LATS1\n", + "i_search = 3\n", + "Looking for paths with length: 3 for node SRC and LATS1\n", + "[['SRC', 'RAF1', 'STK3', 'LATS1'], ['SRC', 'RAF1', 'STK4', 'LATS1'], ['SRC', 'PAK2', 'NF2', 'LATS1']]\n", + "P12931 P04049\n", + "P04049 Q13188\n", + "Q13188 O95835\n", + "P12931 P04049\n", + "P04049 Q13043\n", + "Q13043 O95835\n", + "P12931 Q13177\n", + "Q13177 P35240\n", + "P35240 O95835\n", + "P12931 Q05397\n", + "P12931 P19022\n", + "P12931 Q14289\n", + "P12931 P35222\n", + "P12931 O75553\n", + "P12931 P08581\n", + "P12931 Q15139\n", + "P12931 O60716\n", + "P12931 Q13177\n", + "P45983 P12931\n", + "P12931 P04049\n", + "P35222 P46531\n", + "O75553 P46531\n", + "Q14289 Q05397\n", + "P08581 Q05397\n", + "P12830 P35222\n", + "P08581 P12830\n", + "Q15139 P12830\n", + "O60716 P12830\n", + "P19022 P35222\n", + "O60716 P19022\n", + "Q13177 P08670\n", + "O95819 O43318\n", + "O95819 Q13233\n", + "Q13188 O95835\n", + "Q13043 O95835\n", + "P35240 O95835\n", + "Q13188 Q9NRM7\n", + "Q13043 Q9NRM7\n", + "P35240 Q9NRM7\n", + "Q15139 P35222\n", + "Q13177 P04049\n", + "Q13177 P35240\n", + "O43318 P45983\n", + "Q13233 P45983\n", + "P45983 Q13043\n", + "P04049 Q13188\n", + "P04049 Q13043\n", + "P35240 Q13188\n", + "P35240 Q13043\n", + "looking for paths in the network with length: 0 for node SRC and LATS2\n", + "looking for paths in the network with length: 1 for node SRC and LATS2\n", + "looking for paths in the network with length: 2 for node SRC and LATS2\n", + "looking for paths in the network with length: 3 for node SRC and LATS2\n", + "Found a path!\n", + "[['SRC', 'PAK2', 'NF2', 'LATS2'], ['SRC', 'RAF1', 'STK3', 'LATS2'], ['SRC', 'RAF1', 'STK4', 'LATS2']]\n", + "looking for paths in the network with length: 0 for node SRC and PTK2B\n", + "looking for paths in the network with length: 1 for node SRC and PTK2B\n", + "Found a path!\n", + "[['SRC', 'PTK2B']]\n", + "looking for paths in the network with length: 0 for node NOTCH1 and PTK2\n", + "looking for paths in the network with length: 1 for node NOTCH1 and PTK2\n", + "looking for paths in the network with length: 2 for node NOTCH1 and PTK2\n", + "looking for paths in the network with length: 3 for node NOTCH1 and PTK2\n", + "looking for paths in the network with length: 4 for node NOTCH1 and PTK2\n", + "looking for paths in the network with length: 5 for node NOTCH1 and PTK2\n", + "looking for paths in the network with length: 6 for node NOTCH1 and PTK2\n", + "i_search = 3\n", + "Looking for paths with length: 0 for node NOTCH1 and PTK2\n", + "i_search = 3\n", + "Looking for paths with length: 1 for node NOTCH1 and PTK2\n", + "i_search = 3\n", + "Looking for paths with length: 2 for node NOTCH1 and PTK2\n", + "i_search = 3\n", + "Looking for paths with length: 3 for node NOTCH1 and PTK2\n", + "[['NOTCH1', 'SMAD3', 'BCAR1', 'PTK2'], ['NOTCH1', 'LCK', 'PTPRH', 'PTK2']]\n", + "P84022 P46531\n", + "P56945 P84022\n", + "Q05397 P56945\n", + "P06239 P46531\n", + "Q9HD43 P06239\n", + "Q9HD43 Q05397\n", + "P12931 Q05397\n", + "P12931 P19022\n", + "P12931 Q14289\n", + "P12931 P35222\n", + "P12931 O75553\n", + "P12931 P08581\n", + "P12931 Q15139\n", + "P12931 O60716\n", + "P12931 Q13177\n", + "P45983 P12931\n", + "P12931 P04049\n", + "P12931 P56945\n", + "Q9HD43 P12931\n", + "P35222 P46531\n", + "O75553 P46531\n", + "P84022 P46531\n", + "P06239 P46531\n", + "Q14289 Q05397\n", + "P08581 Q05397\n", + "Q05397 P56945\n", + "Q05397 Q9HD43\n", + "Q9HD43 Q05397\n", + "P12830 P35222\n", + "P08581 P12830\n", + "Q15139 P12830\n", + "O60716 P12830\n", + "P19022 P35222\n", + "O60716 P19022\n", + "Q13177 P08670\n", + "O95819 O43318\n", + "O95819 Q13233\n", + "Q13188 O95835\n", + "Q13043 O95835\n", + "P35240 O95835\n", + "Q13188 Q9NRM7\n", + "Q13043 Q9NRM7\n", + "P35240 Q9NRM7\n", + "Q15139 P35222\n", + "Q13177 P04049\n", + "Q13177 P35240\n", + "O43318 P45983\n", + "Q13233 P45983\n", + "P45983 Q13043\n", + "P45983 P84022\n", + "O43318 P84022\n", + "P04049 Q13188\n", + "P04049 Q13043\n", + "P06239 P04049\n", + "P35240 Q13188\n", + "P35240 Q13043\n", + "P56945 P84022\n", + "Q9HD43 P56945\n", + "Q9HD43 P06239\n", + "looking for paths in the network with length: 0 for node NOTCH1 and CDH1\n", + "looking for paths in the network with length: 1 for node NOTCH1 and CDH1\n", + "looking for paths in the network with length: 2 for node NOTCH1 and CDH1\n", + "Found a path!\n", + "[['NOTCH1', 'CTNNB1', 'CDH1']]\n", + "looking for paths in the network with length: 0 for node NOTCH1 and CDH2\n", + "looking for paths in the network with length: 1 for node NOTCH1 and CDH2\n", + "looking for paths in the network with length: 2 for node NOTCH1 and CDH2\n", + "Found a path!\n", + "[['NOTCH1', 'CTNNB1', 'CDH2']]\n", + "looking for paths in the network with length: 0 for node NOTCH1 and VIM\n", + "looking for paths in the network with length: 1 for node NOTCH1 and VIM\n", + "looking for paths in the network with length: 2 for node NOTCH1 and VIM\n", + "looking for paths in the network with length: 3 for node NOTCH1 and VIM\n", + "looking for paths in the network with length: 4 for node NOTCH1 and VIM\n", + "looking for paths in the network with length: 5 for node NOTCH1 and VIM\n", + "looking for paths in the network with length: 6 for node NOTCH1 and VIM\n", + "i_search = 3\n", + "Looking for paths with length: 0 for node NOTCH1 and VIM\n", + "i_search = 3\n", + "Looking for paths with length: 1 for node NOTCH1 and VIM\n", + "i_search = 3\n", + "Looking for paths with length: 2 for node NOTCH1 and VIM\n", + "i_search = 3\n", + "Looking for paths with length: 3 for node NOTCH1 and VIM\n", + "looking for paths in the network with length: 0 for node NOTCH1 and MAP4K4\n", + "looking for paths in the network with length: 1 for node NOTCH1 and MAP4K4\n", + "looking for paths in the network with length: 2 for node NOTCH1 and MAP4K4\n", + "looking for paths in the network with length: 3 for node NOTCH1 and MAP4K4\n", + "Found a path!\n", + "[['NOTCH1', 'SMAD3', 'MAP3K7', 'MAP4K4']]\n", + "looking for paths in the network with length: 0 for node NOTCH1 and LATS1\n", + "looking for paths in the network with length: 1 for node NOTCH1 and LATS1\n", + "looking for paths in the network with length: 2 for node NOTCH1 and LATS1\n", + "looking for paths in the network with length: 3 for node NOTCH1 and LATS1\n", + "looking for paths in the network with length: 4 for node NOTCH1 and LATS1\n", + "looking for paths in the network with length: 5 for node NOTCH1 and LATS1\n", + "looking for paths in the network with length: 6 for node NOTCH1 and LATS1\n", + "i_search = 3\n", + "Looking for paths with length: 0 for node NOTCH1 and LATS1\n", + "i_search = 3\n", + "Looking for paths with length: 1 for node NOTCH1 and LATS1\n", + "i_search = 3\n", + "Looking for paths with length: 2 for node NOTCH1 and LATS1\n", + "i_search = 3\n", + "Looking for paths with length: 3 for node NOTCH1 and LATS1\n", + "[['NOTCH1', 'SMAD3', 'WWTR1', 'LATS1'], ['NOTCH1', 'CTNNB1', 'YAP1', 'LATS1'], ['NOTCH1', 'RUNX2', 'WWTR1', 'LATS1'], ['NOTCH1', 'RUNX2', 'YAP1', 'LATS1']]\n", + "P84022 P46531\n", + "Q9GZV5 P84022\n", + "O95835 Q9GZV5\n", + "P35222 P46531\n", + "P46937 P35222\n", + "O95835 P46937\n", + "Q13950 P46531\n", + "Q9GZV5 Q13950\n", + "O95835 Q9GZV5\n", + "Q13950 P46531\n", + "P46937 Q13950\n", + "O95835 P46937\n", + "P12931 Q05397\n", + "P12931 P19022\n", + "P12931 Q14289\n", + "P12931 P35222\n", + "P12931 O75553\n", + "P12931 P08581\n", + "P12931 Q15139\n", + "P12931 O60716\n", + "P12931 Q13177\n", + "P45983 P12931\n", + "P12931 P04049\n", + "P12931 P56945\n", + "Q9HD43 P12931\n", + "P35222 P46531\n", + "O75553 P46531\n", + "P84022 P46531\n", + "P06239 P46531\n", + "Q13950 P46531\n", + "Q14289 Q05397\n", + "P08581 Q05397\n", + "Q05397 P56945\n", + "Q05397 Q9HD43\n", + "Q9HD43 Q05397\n", + "P12830 P35222\n", + "P08581 P12830\n", + "Q15139 P12830\n", + "O60716 P12830\n", + "P19022 P35222\n", + "O60716 P19022\n", + "Q13177 P08670\n", + "O95819 O43318\n", + "O95819 Q13233\n", + "Q13188 O95835\n", + "Q13043 O95835\n", + "P35240 O95835\n", + "O95835 Q9GZV5\n", + "O95835 P46937\n", + "Q13188 Q9NRM7\n", + "Q13043 Q9NRM7\n", + "P35240 Q9NRM7\n", + "Q9NRM7 Q9GZV5\n", + "Q9NRM7 P46937\n", + "Q15139 P35222\n", + "P46937 P35222\n", + "Q13177 P04049\n", + "Q13177 P35240\n", + "O43318 P45983\n", + "Q13233 P45983\n", + "P45983 Q13043\n", + "P45983 P84022\n", + "O43318 P84022\n", + "P04049 Q13188\n", + "P04049 Q13043\n", + "P06239 P04049\n", + "P35240 Q13188\n", + "P35240 Q13043\n", + "P56945 P84022\n", + "Q9GZV5 P84022\n", + "P84022 Q13950\n", + "Q9HD43 P56945\n", + "Q9HD43 P06239\n", + "Q9GZV5 Q13950\n", + "P46937 Q13950\n", + "looking for paths in the network with length: 0 for node NOTCH1 and LATS2\n", + "looking for paths in the network with length: 1 for node NOTCH1 and LATS2\n", + "looking for paths in the network with length: 2 for node NOTCH1 and LATS2\n", + "looking for paths in the network with length: 3 for node NOTCH1 and LATS2\n", + "Found a path!\n", + "[['NOTCH1', 'SMAD3', 'WWTR1', 'LATS2'], ['NOTCH1', 'CTNNB1', 'YAP1', 'LATS2'], ['NOTCH1', 'RUNX2', 'WWTR1', 'LATS2'], ['NOTCH1', 'RUNX2', 'YAP1', 'LATS2']]\n", + "looking for paths in the network with length: 0 for node NOTCH1 and PTK2B\n", + "looking for paths in the network with length: 1 for node NOTCH1 and PTK2B\n", + "looking for paths in the network with length: 2 for node NOTCH1 and PTK2B\n", + "looking for paths in the network with length: 3 for node NOTCH1 and PTK2B\n", + "looking for paths in the network with length: 4 for node NOTCH1 and PTK2B\n", + "Found a path!\n", + "[['NOTCH1', 'SMAD3', 'BCAR1', 'PTK2', 'PTK2B'], ['NOTCH1', 'LCK', 'PTPRH', 'PTK2', 'PTK2B']]\n", + "looking for paths in the network with length: 0 for node PTK2 and CDH1\n", + "looking for paths in the network with length: 1 for node PTK2 and CDH1\n", + "looking for paths in the network with length: 2 for node PTK2 and CDH1\n", + "looking for paths in the network with length: 3 for node PTK2 and CDH1\n", + "looking for paths in the network with length: 4 for node PTK2 and CDH1\n", + "Found a path!\n", + "[['PTK2', 'PTPRH', 'SRC', 'PRKD1', 'CDH1'], ['PTK2', 'PTPRH', 'SRC', 'CTNND1', 'CDH1'], ['PTK2', 'PTPRH', 'SRC', 'MET', 'CDH1']]\n", + "looking for paths in the network with length: 0 for node PTK2 and CDH2\n", + "looking for paths in the network with length: 1 for node PTK2 and CDH2\n", + "looking for paths in the network with length: 2 for node PTK2 and CDH2\n", + "looking for paths in the network with length: 3 for node PTK2 and CDH2\n", + "Found a path!\n", + "[['PTK2', 'PTPRH', 'SRC', 'CDH2']]\n", + "looking for paths in the network with length: 0 for node PTK2 and VIM\n", + "looking for paths in the network with length: 1 for node PTK2 and VIM\n", + "looking for paths in the network with length: 2 for node PTK2 and VIM\n", + "looking for paths in the network with length: 3 for node PTK2 and VIM\n", + "looking for paths in the network with length: 4 for node PTK2 and VIM\n", + "Found a path!\n", + "[['PTK2', 'PTPRH', 'SRC', 'PAK2', 'VIM']]\n", + "looking for paths in the network with length: 0 for node PTK2 and MAP4K4\n", + "looking for paths in the network with length: 1 for node PTK2 and MAP4K4\n", + "looking for paths in the network with length: 2 for node PTK2 and MAP4K4\n", + "looking for paths in the network with length: 3 for node PTK2 and MAP4K4\n", + "looking for paths in the network with length: 4 for node PTK2 and MAP4K4\n", + "Found a path!\n", + "[['PTK2', 'SRC', 'MAPK8', 'MAP3K7', 'MAP4K4'], ['PTK2', 'SRC', 'MAPK8', 'MAP3K1', 'MAP4K4']]\n", + "looking for paths in the network with length: 0 for node PTK2 and LATS1\n", + "looking for paths in the network with length: 1 for node PTK2 and LATS1\n", + "looking for paths in the network with length: 2 for node PTK2 and LATS1\n", + "looking for paths in the network with length: 3 for node PTK2 and LATS1\n", + "looking for paths in the network with length: 4 for node PTK2 and LATS1\n", + "looking for paths in the network with length: 5 for node PTK2 and LATS1\n", + "Found a path!\n", + "[['PTK2', 'PTPRH', 'SRC', 'PAK2', 'NF2', 'LATS1'], ['PTK2', 'PTPRH', 'SRC', 'RAF1', 'STK3', 'LATS1'], ['PTK2', 'PTPRH', 'SRC', 'RAF1', 'STK4', 'LATS1'], ['PTK2', 'PTPRH', 'LCK', 'RAF1', 'STK3', 'LATS1'], ['PTK2', 'PTPRH', 'LCK', 'RAF1', 'STK4', 'LATS1']]\n", + "looking for paths in the network with length: 0 for node PTK2 and LATS2\n", + "looking for paths in the network with length: 1 for node PTK2 and LATS2\n", + "looking for paths in the network with length: 2 for node PTK2 and LATS2\n", + "looking for paths in the network with length: 3 for node PTK2 and LATS2\n", + "looking for paths in the network with length: 4 for node PTK2 and LATS2\n", + "looking for paths in the network with length: 5 for node PTK2 and LATS2\n", + "Found a path!\n", + "[['PTK2', 'PTPRH', 'SRC', 'PAK2', 'NF2', 'LATS2'], ['PTK2', 'PTPRH', 'SRC', 'RAF1', 'STK3', 'LATS2'], ['PTK2', 'PTPRH', 'SRC', 'RAF1', 'STK4', 'LATS2'], ['PTK2', 'PTPRH', 'LCK', 'RAF1', 'STK3', 'LATS2'], ['PTK2', 'PTPRH', 'LCK', 'RAF1', 'STK4', 'LATS2']]\n", + "looking for paths in the network with length: 0 for node PTK2 and PTK2B\n", + "looking for paths in the network with length: 1 for node PTK2 and PTK2B\n", + "Found a path!\n", + "[['PTK2', 'PTK2B']]\n", + "looking for paths in the network with length: 0 for node CDH1 and CDH2\n", + "looking for paths in the network with length: 1 for node CDH1 and CDH2\n", + "looking for paths in the network with length: 2 for node CDH1 and CDH2\n", + "looking for paths in the network with length: 3 for node CDH1 and CDH2\n", + "looking for paths in the network with length: 4 for node CDH1 and CDH2\n", + "looking for paths in the network with length: 5 for node CDH1 and CDH2\n", + "looking for paths in the network with length: 6 for node CDH1 and CDH2\n", + "i_search = 3\n", + "Looking for paths with length: 0 for node CDH1 and CDH2\n", + "i_search = 3\n", + "Looking for paths with length: 1 for node CDH1 and CDH2\n", + "i_search = 3\n", + "Looking for paths with length: 2 for node CDH1 and CDH2\n", + "i_search = 3\n", + "Looking for paths with length: 3 for node CDH1 and CDH2\n", + "[['CDH1', 'EGFR', 'CTNND1', 'CDH2']]\n", + "P12830 P00533\n", + "P00533 O60716\n", + "O60716 P19022\n", + "P12931 Q05397\n", + "P12931 P19022\n", + "P12931 Q14289\n", + "P12931 P35222\n", + "P12931 O75553\n", + "P12931 P08581\n", + "P12931 Q15139\n", + "P12931 O60716\n", + "P12931 Q13177\n", + "P45983 P12931\n", + "P12931 P04049\n", + "P12931 P56945\n", + "Q9HD43 P12931\n", + "P12931 P00533\n", + "P35222 P46531\n", + "O75553 P46531\n", + "P84022 P46531\n", + "P06239 P46531\n", + "Q13950 P46531\n", + "Q14289 Q05397\n", + "P08581 Q05397\n", + "Q05397 P56945\n", + "Q05397 Q9HD43\n", + "Q9HD43 Q05397\n", + "P00533 Q05397\n", + "P12830 P35222\n", + "P08581 P12830\n", + "Q15139 P12830\n", + "O60716 P12830\n", + "P12830 P00533\n", + "P19022 P35222\n", + "O60716 P19022\n", + "Q13177 P08670\n", + "O95819 O43318\n", + "O95819 Q13233\n", + "Q13188 O95835\n", + "Q13043 O95835\n", + "P35240 O95835\n", + "O95835 Q9GZV5\n", + "O95835 P46937\n", + "Q13188 Q9NRM7\n", + "Q13043 Q9NRM7\n", + "P35240 Q9NRM7\n", + "Q9NRM7 Q9GZV5\n", + "Q9NRM7 P46937\n", + "Q14289 P00533\n", + "Q15139 P35222\n", + "P46937 P35222\n", + "P00533 P35222\n", + "Q15139 P00533\n", + "P00533 O60716\n", + "Q13177 P04049\n", + "Q13177 P35240\n", + "O43318 P45983\n", + "Q13233 P45983\n", + "P45983 Q13043\n", + "P45983 P84022\n", + "O43318 P84022\n", + "P04049 Q13188\n", + "P04049 Q13043\n", + "P06239 P04049\n", + "P35240 Q13188\n", + "P35240 Q13043\n", + "P56945 P84022\n", + "Q9GZV5 P84022\n", + "P84022 Q13950\n", + "Q9HD43 P56945\n", + "P00533 P56945\n", + "Q9HD43 P06239\n", + "Q9GZV5 Q13950\n", + "P46937 Q13950\n", + "looking for paths in the network with length: 0 for node CDH1 and VIM\n", + "looking for paths in the network with length: 1 for node CDH1 and VIM\n", + "looking for paths in the network with length: 2 for node CDH1 and VIM\n", + "looking for paths in the network with length: 3 for node CDH1 and VIM\n", + "looking for paths in the network with length: 4 for node CDH1 and VIM\n", + "looking for paths in the network with length: 5 for node CDH1 and VIM\n", + "looking for paths in the network with length: 6 for node CDH1 and VIM\n", + "Found a path!\n", + "[['CDH1', 'EGFR', 'PTK2', 'PTPRH', 'SRC', 'PAK2', 'VIM']]\n", + "looking for paths in the network with length: 0 for node CDH1 and MAP4K4\n", + "looking for paths in the network with length: 1 for node CDH1 and MAP4K4\n", + "looking for paths in the network with length: 2 for node CDH1 and MAP4K4\n", + "looking for paths in the network with length: 3 for node CDH1 and MAP4K4\n", + "looking for paths in the network with length: 4 for node CDH1 and MAP4K4\n", + "looking for paths in the network with length: 5 for node CDH1 and MAP4K4\n", + "Found a path!\n", + "[['CDH1', 'CTNND1', 'SRC', 'MAPK8', 'MAP3K7', 'MAP4K4'], ['CDH1', 'CTNND1', 'SRC', 'MAPK8', 'MAP3K1', 'MAP4K4'], ['CDH1', 'PRKD1', 'SRC', 'MAPK8', 'MAP3K7', 'MAP4K4'], ['CDH1', 'PRKD1', 'SRC', 'MAPK8', 'MAP3K1', 'MAP4K4'], ['CDH1', 'MET', 'SRC', 'MAPK8', 'MAP3K7', 'MAP4K4'], ['CDH1', 'MET', 'SRC', 'MAPK8', 'MAP3K1', 'MAP4K4']]\n", + "looking for paths in the network with length: 0 for node CDH1 and LATS1\n", + "looking for paths in the network with length: 1 for node CDH1 and LATS1\n", + "looking for paths in the network with length: 2 for node CDH1 and LATS1\n", + "looking for paths in the network with length: 3 for node CDH1 and LATS1\n", + "looking for paths in the network with length: 4 for node CDH1 and LATS1\n", + "looking for paths in the network with length: 5 for node CDH1 and LATS1\n", + "looking for paths in the network with length: 6 for node CDH1 and LATS1\n", + "i_search = 3\n", + "Looking for paths with length: 0 for node CDH1 and LATS1\n", + "i_search = 3\n", + "Looking for paths with length: 1 for node CDH1 and LATS1\n", + "i_search = 3\n", + "Looking for paths with length: 2 for node CDH1 and LATS1\n", + "i_search = 3\n", + "Looking for paths with length: 3 for node CDH1 and LATS1\n", + "looking for paths in the network with length: 0 for node CDH1 and LATS2\n", + "looking for paths in the network with length: 1 for node CDH1 and LATS2\n", + "looking for paths in the network with length: 2 for node CDH1 and LATS2\n", + "looking for paths in the network with length: 3 for node CDH1 and LATS2\n", + "looking for paths in the network with length: 4 for node CDH1 and LATS2\n", + "looking for paths in the network with length: 5 for node CDH1 and LATS2\n", + "looking for paths in the network with length: 6 for node CDH1 and LATS2\n", + "i_search = 3\n", + "Looking for paths with length: 0 for node CDH1 and LATS2\n", + "i_search = 3\n", + "Looking for paths with length: 1 for node CDH1 and LATS2\n", + "i_search = 3\n", + "Looking for paths with length: 2 for node CDH1 and LATS2\n", + "i_search = 3\n", + "Looking for paths with length: 3 for node CDH1 and LATS2\n", + "looking for paths in the network with length: 0 for node CDH1 and PTK2B\n", + "looking for paths in the network with length: 1 for node CDH1 and PTK2B\n", + "looking for paths in the network with length: 2 for node CDH1 and PTK2B\n", + "looking for paths in the network with length: 3 for node CDH1 and PTK2B\n", + "Found a path!\n", + "[['CDH1', 'CTNND1', 'EGFR', 'PTK2B']]\n", + "looking for paths in the network with length: 0 for node CDH2 and VIM\n", + "looking for paths in the network with length: 1 for node CDH2 and VIM\n", + "looking for paths in the network with length: 2 for node CDH2 and VIM\n", + "looking for paths in the network with length: 3 for node CDH2 and VIM\n", + "looking for paths in the network with length: 4 for node CDH2 and VIM\n", + "looking for paths in the network with length: 5 for node CDH2 and VIM\n", + "looking for paths in the network with length: 6 for node CDH2 and VIM\n", + "i_search = 3\n", + "Looking for paths with length: 0 for node CDH2 and VIM\n", + "i_search = 3\n", + "Looking for paths with length: 1 for node CDH2 and VIM\n", + "i_search = 3\n", + "Looking for paths with length: 2 for node CDH2 and VIM\n", + "i_search = 3\n", + "Looking for paths with length: 3 for node CDH2 and VIM\n", + "looking for paths in the network with length: 0 for node CDH2 and MAP4K4\n", + "looking for paths in the network with length: 1 for node CDH2 and MAP4K4\n", + "looking for paths in the network with length: 2 for node CDH2 and MAP4K4\n", + "looking for paths in the network with length: 3 for node CDH2 and MAP4K4\n", + "looking for paths in the network with length: 4 for node CDH2 and MAP4K4\n", + "Found a path!\n", + "[['CDH2', 'SRC', 'MAPK8', 'MAP3K7', 'MAP4K4'], ['CDH2', 'SRC', 'MAPK8', 'MAP3K1', 'MAP4K4']]\n", + "looking for paths in the network with length: 0 for node CDH2 and LATS1\n", + "looking for paths in the network with length: 1 for node CDH2 and LATS1\n", + "looking for paths in the network with length: 2 for node CDH2 and LATS1\n", + "looking for paths in the network with length: 3 for node CDH2 and LATS1\n", + "looking for paths in the network with length: 4 for node CDH2 and LATS1\n", + "looking for paths in the network with length: 5 for node CDH2 and LATS1\n", + "looking for paths in the network with length: 6 for node CDH2 and LATS1\n", + "i_search = 3\n", + "Looking for paths with length: 0 for node CDH2 and LATS1\n", + "i_search = 3\n", + "Looking for paths with length: 1 for node CDH2 and LATS1\n", + "i_search = 3\n", + "Looking for paths with length: 2 for node CDH2 and LATS1\n", + "i_search = 3\n", + "Looking for paths with length: 3 for node CDH2 and LATS1\n", + "looking for paths in the network with length: 0 for node CDH2 and LATS2\n", + "looking for paths in the network with length: 1 for node CDH2 and LATS2\n", + "looking for paths in the network with length: 2 for node CDH2 and LATS2\n", + "looking for paths in the network with length: 3 for node CDH2 and LATS2\n", + "looking for paths in the network with length: 4 for node CDH2 and LATS2\n", + "looking for paths in the network with length: 5 for node CDH2 and LATS2\n", + "looking for paths in the network with length: 6 for node CDH2 and LATS2\n", + "i_search = 3\n", + "Looking for paths with length: 0 for node CDH2 and LATS2\n", + "i_search = 3\n", + "Looking for paths with length: 1 for node CDH2 and LATS2\n", + "i_search = 3\n", + "Looking for paths with length: 2 for node CDH2 and LATS2\n", + "i_search = 3\n", + "Looking for paths with length: 3 for node CDH2 and LATS2\n", + "looking for paths in the network with length: 0 for node CDH2 and PTK2B\n", + "looking for paths in the network with length: 1 for node CDH2 and PTK2B\n", + "looking for paths in the network with length: 2 for node CDH2 and PTK2B\n", + "looking for paths in the network with length: 3 for node CDH2 and PTK2B\n", + "Found a path!\n", + "[['CDH2', 'CTNND1', 'EGFR', 'PTK2B']]\n", + "looking for paths in the network with length: 0 for node VIM and MAP4K4\n", + "looking for paths in the network with length: 1 for node VIM and MAP4K4\n", + "looking for paths in the network with length: 2 for node VIM and MAP4K4\n", + "looking for paths in the network with length: 3 for node VIM and MAP4K4\n", + "looking for paths in the network with length: 4 for node VIM and MAP4K4\n", + "looking for paths in the network with length: 5 for node VIM and MAP4K4\n", + "Found a path!\n", + "[['VIM', 'PAK2', 'SRC', 'MAPK8', 'MAP3K7', 'MAP4K4'], ['VIM', 'PAK2', 'SRC', 'MAPK8', 'MAP3K1', 'MAP4K4']]\n", + "looking for paths in the network with length: 0 for node VIM and LATS1\n", + "looking for paths in the network with length: 1 for node VIM and LATS1\n", + "looking for paths in the network with length: 2 for node VIM and LATS1\n", + "looking for paths in the network with length: 3 for node VIM and LATS1\n", + "looking for paths in the network with length: 4 for node VIM and LATS1\n", + "looking for paths in the network with length: 5 for node VIM and LATS1\n", + "looking for paths in the network with length: 6 for node VIM and LATS1\n", + "i_search = 3\n", + "Looking for paths with length: 0 for node VIM and LATS1\n", + "i_search = 3\n", + "Looking for paths with length: 1 for node VIM and LATS1\n", + "i_search = 3\n", + "Looking for paths with length: 2 for node VIM and LATS1\n", + "i_search = 3\n", + "Looking for paths with length: 3 for node VIM and LATS1\n", + "looking for paths in the network with length: 0 for node VIM and LATS2\n", + "looking for paths in the network with length: 1 for node VIM and LATS2\n", + "looking for paths in the network with length: 2 for node VIM and LATS2\n", + "looking for paths in the network with length: 3 for node VIM and LATS2\n", + "looking for paths in the network with length: 4 for node VIM and LATS2\n", + "looking for paths in the network with length: 5 for node VIM and LATS2\n", + "looking for paths in the network with length: 6 for node VIM and LATS2\n", + "i_search = 3\n", + "Looking for paths with length: 0 for node VIM and LATS2\n", + "i_search = 3\n", + "Looking for paths with length: 1 for node VIM and LATS2\n", + "i_search = 3\n", + "Looking for paths with length: 2 for node VIM and LATS2\n", + "i_search = 3\n", + "Looking for paths with length: 3 for node VIM and LATS2\n", + "looking for paths in the network with length: 0 for node VIM and PTK2B\n", + "looking for paths in the network with length: 1 for node VIM and PTK2B\n", + "looking for paths in the network with length: 2 for node VIM and PTK2B\n", + "looking for paths in the network with length: 3 for node VIM and PTK2B\n", + "looking for paths in the network with length: 4 for node VIM and PTK2B\n", + "looking for paths in the network with length: 5 for node VIM and PTK2B\n", + "Found a path!\n", + "[['VIM', 'PAK2', 'SRC', 'PTPRH', 'PTK2', 'PTK2B']]\n", + "looking for paths in the network with length: 0 for node MAP4K4 and LATS1\n", + "looking for paths in the network with length: 1 for node MAP4K4 and LATS1\n", + "looking for paths in the network with length: 2 for node MAP4K4 and LATS1\n", + "looking for paths in the network with length: 3 for node MAP4K4 and LATS1\n", + "looking for paths in the network with length: 4 for node MAP4K4 and LATS1\n", + "Found a path!\n", + "[['MAP4K4', 'MAP3K7', 'MAPK8', 'STK4', 'LATS1'], ['MAP4K4', 'MAP3K1', 'MAPK8', 'STK4', 'LATS1']]\n", + "looking for paths in the network with length: 0 for node MAP4K4 and LATS2\n", + "looking for paths in the network with length: 1 for node MAP4K4 and LATS2\n", + "looking for paths in the network with length: 2 for node MAP4K4 and LATS2\n", + "looking for paths in the network with length: 3 for node MAP4K4 and LATS2\n", + "looking for paths in the network with length: 4 for node MAP4K4 and LATS2\n", + "Found a path!\n", + "[['MAP4K4', 'MAP3K7', 'MAPK8', 'STK4', 'LATS2'], ['MAP4K4', 'MAP3K1', 'MAPK8', 'STK4', 'LATS2']]\n", + "looking for paths in the network with length: 0 for node MAP4K4 and PTK2B\n", + "looking for paths in the network with length: 1 for node MAP4K4 and PTK2B\n", + "looking for paths in the network with length: 2 for node MAP4K4 and PTK2B\n", + "looking for paths in the network with length: 3 for node MAP4K4 and PTK2B\n", + "looking for paths in the network with length: 4 for node MAP4K4 and PTK2B\n", + "Found a path!\n", + "[['MAP4K4', 'MAP3K7', 'MAPK8', 'SRC', 'PTK2B'], ['MAP4K4', 'MAP3K1', 'MAPK8', 'SRC', 'PTK2B']]\n", + "looking for paths in the network with length: 0 for node LATS1 and LATS2\n", + "looking for paths in the network with length: 1 for node LATS1 and LATS2\n", + "looking for paths in the network with length: 2 for node LATS1 and LATS2\n", + "looking for paths in the network with length: 3 for node LATS1 and LATS2\n", + "looking for paths in the network with length: 4 for node LATS1 and LATS2\n", + "looking for paths in the network with length: 5 for node LATS1 and LATS2\n", + "looking for paths in the network with length: 6 for node LATS1 and LATS2\n", + "i_search = 3\n", + "Looking for paths with length: 0 for node LATS1 and LATS2\n", + "i_search = 3\n", + "Looking for paths with length: 1 for node LATS1 and LATS2\n", + "i_search = 3\n", + "Looking for paths with length: 2 for node LATS1 and LATS2\n", + "i_search = 3\n", + "Looking for paths with length: 3 for node LATS1 and LATS2\n", + "looking for paths in the network with length: 0 for node LATS1 and PTK2B\n", + "looking for paths in the network with length: 1 for node LATS1 and PTK2B\n", + "looking for paths in the network with length: 2 for node LATS1 and PTK2B\n", + "looking for paths in the network with length: 3 for node LATS1 and PTK2B\n", + "looking for paths in the network with length: 4 for node LATS1 and PTK2B\n", + "looking for paths in the network with length: 5 for node LATS1 and PTK2B\n", + "looking for paths in the network with length: 6 for node LATS1 and PTK2B\n", + "Found a path!\n", + "[['LATS1', 'STK3', 'RAF1', 'LCK', 'PTPRH', 'PTK2', 'PTK2B'], ['LATS1', 'STK3', 'RAF1', 'SRC', 'PTPRH', 'PTK2', 'PTK2B'], ['LATS1', 'STK4', 'RAF1', 'LCK', 'PTPRH', 'PTK2', 'PTK2B'], ['LATS1', 'STK4', 'RAF1', 'SRC', 'PTPRH', 'PTK2', 'PTK2B'], ['LATS1', 'NF2', 'PAK2', 'SRC', 'PTPRH', 'PTK2', 'PTK2B']]\n", + "looking for paths in the network with length: 0 for node LATS2 and PTK2B\n", + "looking for paths in the network with length: 1 for node LATS2 and PTK2B\n", + "looking for paths in the network with length: 2 for node LATS2 and PTK2B\n", + "looking for paths in the network with length: 3 for node LATS2 and PTK2B\n", + "looking for paths in the network with length: 4 for node LATS2 and PTK2B\n", + "looking for paths in the network with length: 5 for node LATS2 and PTK2B\n", + "looking for paths in the network with length: 6 for node LATS2 and PTK2B\n", + "Found a path!\n", + "[['LATS2', 'STK3', 'RAF1', 'LCK', 'PTPRH', 'PTK2', 'PTK2B'], ['LATS2', 'STK3', 'RAF1', 'SRC', 'PTPRH', 'PTK2', 'PTK2B'], ['LATS2', 'STK4', 'RAF1', 'LCK', 'PTPRH', 'PTK2', 'PTK2B'], ['LATS2', 'STK4', 'RAF1', 'SRC', 'PTPRH', 'PTK2', 'PTK2B'], ['LATS2', 'NF2', 'PAK2', 'SRC', 'PTPRH', 'PTK2', 'PTK2B']]\n", + "CPU times: user 1min 50s, sys: 22.9 ms, total: 1min 50s\n", + "Wall time: 1min 50s\n" + ] + } + ], + "source": [ + "%%time\n", + "new_net1.complete_connection(mode=\"ALL\", maxlen=6, k_mean=\"tight\", only_signed=True, connect_node_when_first_introduced=True, consensus=True)" + ] + }, + { + "cell_type": "markdown", + "id": "c6510316-2f47-4e71-89e0-b93da0657897", + "metadata": {}, + "source": [ + "#### 2E. Visualize final network" + ] + }, + { + "cell_type": "code", + "execution_count": 9, + "id": "152b9434", + "metadata": {}, + "outputs": [ + { + "data": { + "image/svg+xml": [ + "\n", + "\n", + "\n", + "\n", + "\n", + "\n", + "%3\n", + "\n", + "\n", + "\n", + "SRC\n", + "\n", + "SRC\n", + "\n", + "\n", + "\n", + "PTK2\n", + "\n", + "PTK2\n", + "\n", + "\n", + "\n", + "SRC->PTK2\n", + "\n", + "\n", + "\n", + "\n", + "\n", + "CDH2\n", + "\n", + "CDH2\n", + "\n", + "\n", + "\n", + "SRC->CDH2\n", + "\n", + "\n", + "\n", + "\n", + "\n", + "\n", + "PTK2B\n", + "\n", + "PTK2B\n", + "\n", + "\n", + "\n", + "SRC->PTK2B\n", + "\n", + "\n", + "\n", + "\n", + "\n", + "CTNNB1\n", + "\n", + "CTNNB1\n", + "\n", + "\n", + "\n", + "SRC->CTNNB1\n", + "\n", + "\n", + "\n", + "\n", + "\n", + "DAB1\n", + "\n", + "DAB1\n", + "\n", + "\n", + "\n", + "SRC->DAB1\n", + "\n", + "\n", + "\n", + "\n", + "\n", + "MET\n", + "\n", + "MET\n", + "\n", + "\n", + "\n", + "SRC->MET\n", + "\n", + "\n", + "\n", + "\n", + "\n", + "\n", + "PRKD1\n", + "\n", + "PRKD1\n", + "\n", + "\n", + "\n", + "SRC->PRKD1\n", + "\n", + "\n", + "\n", + "\n", + "\n", + "CTNND1\n", + "\n", + "CTNND1\n", + "\n", + "\n", + "\n", + "SRC->CTNND1\n", + "\n", + "\n", + "\n", + "\n", + "\n", + "PAK2\n", + "\n", + "PAK2\n", + "\n", + "\n", + "\n", + "SRC->PAK2\n", + "\n", + "\n", + "\n", + "\n", + "\n", + "RAF1\n", + "\n", + "RAF1\n", + "\n", + "\n", + "\n", + "SRC->RAF1\n", + "\n", + "\n", + "\n", + "\n", + "\n", + "BCAR1\n", + "\n", + "BCAR1\n", + "\n", + "\n", + "\n", + "SRC->BCAR1\n", + "\n", + "\n", + "\n", + "\n", + "\n", + "EGFR\n", + "\n", + "EGFR\n", + "\n", + "\n", + "\n", + "SRC->EGFR\n", + "\n", + "\n", + "\n", + "\n", + "\n", + "PTK2->BCAR1\n", + "\n", + "\n", + "\n", + "\n", + "\n", + "PTPRH\n", + "\n", + "PTPRH\n", + "\n", + "\n", + "\n", + "PTK2->PTPRH\n", + "\n", + "\n", + "\n", + "\n", + "\n", + "\n", + "CDH2->CTNNB1\n", + "\n", + "\n", + "\n", + "\n", + "\n", + "PTK2B->PTK2\n", + "\n", + "\n", + "\n", + "\n", + "\n", + "PTK2B->EGFR\n", + "\n", + "\n", + "\n", + "\n", + "\n", + "NOTCH1\n", + "\n", + "NOTCH1\n", + "\n", + "\n", + "\n", + "CTNNB1->NOTCH1\n", + "\n", + "\n", + "\n", + "\n", + "\n", + "DAB1->NOTCH1\n", + "\n", + "\n", + "\n", + "\n", + "\n", + "CDH1\n", + "\n", + "CDH1\n", + "\n", + "\n", + "\n", + "CDH1->CTNNB1\n", + "\n", + "\n", + "\n", + "\n", + "\n", + "CDH1->EGFR\n", + "\n", + "\n", + "\n", + "\n", + "\n", + "MET->PTK2\n", + "\n", + "\n", + "\n", + "\n", + "\n", + "MET->CDH1\n", + "\n", + "\n", + "\n", + "\n", + "\n", + "PRKD1->CTNNB1\n", + "\n", + "\n", + "\n", + "\n", + "\n", + "PRKD1->CDH1\n", + "\n", + "\n", + "\n", + "\n", + "\n", + "PRKD1->EGFR\n", + "\n", + "\n", + "\n", + "\n", + "\n", + "CTNND1->CDH2\n", + "\n", + "\n", + "\n", + "\n", + "\n", + "CTNND1->CDH1\n", + "\n", + "\n", + "\n", + "\n", + "\n", + "VIM\n", + "\n", + "VIM\n", + "\n", + "\n", + "\n", + "PAK2->VIM\n", + "\n", + "\n", + "\n", + "\n", + "\n", + "\n", + "PAK2->RAF1\n", + "\n", + "\n", + "\n", + "\n", + "\n", + "NF2\n", + "\n", + "NF2\n", + "\n", + "\n", + "\n", + "PAK2->NF2\n", + "\n", + "\n", + "\n", + "\n", + "\n", + "MAPK8\n", + "\n", + "MAPK8\n", + "\n", + "\n", + "\n", + "MAPK8->SRC\n", + "\n", + "\n", + "\n", + "\n", + "\n", + "STK4\n", + "\n", + "STK4\n", + "\n", + "\n", + "\n", + "MAPK8->STK4\n", + "\n", + "\n", + "\n", + "\n", + "\n", + "SMAD3\n", + "\n", + "SMAD3\n", + "\n", + "\n", + "\n", + "MAPK8->SMAD3\n", + "\n", + "\n", + "\n", + "\n", + "\n", + "MAP3K7\n", + "\n", + "MAP3K7\n", + "\n", + "\n", + "\n", + "MAP3K7->MAPK8\n", + "\n", + "\n", + "\n", + "\n", + "\n", + "MAP3K7->SMAD3\n", + "\n", + "\n", + "\n", + "\n", + "\n", + "\n", + "MAP4K4\n", + "\n", + "MAP4K4\n", + "\n", + "\n", + "\n", + "MAP4K4->MAP3K7\n", + "\n", + "\n", + "\n", + "\n", + "\n", + "MAP3K1\n", + "\n", + "MAP3K1\n", + "\n", + "\n", + "\n", + "MAP4K4->MAP3K1\n", + "\n", + "\n", + "\n", + "\n", + "\n", + "MAP3K1->MAPK8\n", + "\n", + "\n", + "\n", + "\n", + "\n", + "STK3\n", + "\n", + "STK3\n", + "\n", + "\n", + "\n", + "RAF1->STK3\n", + "\n", + "\n", + "\n", + "\n", + "\n", + "\n", + "RAF1->STK4\n", + "\n", + "\n", + "\n", + "\n", + "\n", + "\n", + "LATS1\n", + "\n", + "LATS1\n", + "\n", + "\n", + "\n", + "STK3->LATS1\n", + "\n", + "\n", + "\n", + "\n", + "\n", + "LATS2\n", + "\n", + "LATS2\n", + "\n", + "\n", + "\n", + "STK3->LATS2\n", + "\n", + "\n", + "\n", + "\n", + "\n", + "WWTR1\n", + "\n", + "WWTR1\n", + "\n", + "\n", + "\n", + "LATS1->WWTR1\n", + "\n", + "\n", + "\n", + "\n", + "\n", + "\n", + "YAP1\n", + "\n", + "YAP1\n", + "\n", + "\n", + "\n", + "LATS1->YAP1\n", + "\n", + "\n", + "\n", + "\n", + "\n", + "STK4->LATS1\n", + "\n", + "\n", + "\n", + "\n", + "\n", + "STK4->LATS2\n", + "\n", + "\n", + "\n", + "\n", + "\n", + "NF2->STK3\n", + "\n", + "\n", + "\n", + "\n", + "\n", + "NF2->LATS1\n", + "\n", + "\n", + "\n", + "\n", + "\n", + "NF2->STK4\n", + "\n", + "\n", + "\n", + "\n", + "\n", + "NF2->LATS2\n", + "\n", + "\n", + "\n", + "\n", + "\n", + "LATS2->WWTR1\n", + "\n", + "\n", + "\n", + "\n", + "\n", + "\n", + "LATS2->YAP1\n", + "\n", + "\n", + "\n", + "\n", + "\n", + "\n", + "SMAD3->NOTCH1\n", + "\n", + "\n", + "\n", + "\n", + "\n", + "RUNX2\n", + "\n", + "RUNX2\n", + "\n", + "\n", + "\n", + "SMAD3->RUNX2\n", + "\n", + "\n", + "\n", + "\n", + "\n", + "\n", + "BCAR1->SMAD3\n", + "\n", + "\n", + "\n", + "\n", + "\n", + "\n", + "LCK\n", + "\n", + "LCK\n", + "\n", + "\n", + "\n", + "LCK->NOTCH1\n", + "\n", + "\n", + "\n", + "\n", + "\n", + "LCK->RAF1\n", + "\n", + "\n", + "\n", + "\n", + "\n", + "PTPRH->SRC\n", + "\n", + "\n", + "\n", + "\n", + "\n", + "\n", + "PTPRH->PTK2\n", + "\n", + "\n", + "\n", + "\n", + "\n", + "\n", + "PTPRH->BCAR1\n", + "\n", + "\n", + "\n", + "\n", + "\n", + "\n", + "PTPRH->LCK\n", + "\n", + "\n", + "\n", + "\n", + "\n", + "\n", + "WWTR1->SMAD3\n", + "\n", + "\n", + "\n", + "\n", + "\n", + "WWTR1->RUNX2\n", + "\n", + "\n", + "\n", + "\n", + "\n", + "YAP1->CTNNB1\n", + "\n", + "\n", + "\n", + "\n", + "\n", + "YAP1->RUNX2\n", + "\n", + "\n", + "\n", + "\n", + "\n", + "\n", + "RUNX2->NOTCH1\n", + "\n", + "\n", + "\n", + "\n", + "\n", + "\n", + "EGFR->PTK2\n", + "\n", + "\n", + "\n", + "\n", + "\n", + "EGFR->CTNNB1\n", + "\n", + "\n", + "\n", + "\n", + "\n", + "EGFR->CTNND1\n", + "\n", + "\n", + "\n", + "\n", + "\n", + "\n", + "EGFR->BCAR1\n", + "\n", + "\n", + "\n", + "\n", + "\n", + "\n" + ], + "text/plain": [ + "" + ] + }, + "metadata": {}, + "output_type": "display_data" + } + ], + "source": [ + "#Visualize network\n", + "visualizer1 = NetworkVisualizer(new_net1, color_by='effect')\n", + "visualizer1.render(output_file='network2')" + ] + }, + { + "cell_type": "code", + "execution_count": null, + "id": "80b84e81-abc2-4aae-ad1c-3ebf00355b98", + "metadata": {}, + "outputs": [], + "source": [ + "#Visualize a specific nodes and \n", + "visualizer1 = NetworkVisualizer(new_net1, predefined_node = \"SRC\",color_by='effect')\n", + "visualizer1.render(output_file='network2')" + ] + }, + { + "cell_type": "code", + "execution_count": 15, + "id": "0aa6d076-5310-462e-aa0e-f69da822b962", + "metadata": {}, + "outputs": [ + { + "data": { + "text/html": [ + "
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sourcetargetTypeEffectReferences
6821P12931Q05397NonestimulationAdhesome:10085298;Adhesome:10592173;Adhesome:1...
32968P12931P19022NoneinhibitionACSN:15782139;ACSN:16371504;ACSN:16492141;ACSN...
5154P12931Q14289NonestimulationAdhesome:10329689;Adhesome:10521452;Adhesome:1...
44795Q14289Q05397NonestimulationAdhesome:16760434;HPRD:16760434;KEA:12960434;K...
11582P12931P35222NonestimulationACSN:10593980;ACSN:12123611;ACSN:15782139;ACSN...
..................
67482P00533Q05397NonestimulationACSN:10545505;ACSN:16919435;ACSN:17496910;ACSN...
7631Q14289P00533NonestimulationCA1:11274221;HPRD:10777553;InnateDB:14963038;S...
73973P00533P35222NonestimulationACSN:12040186;ACSN:14585353;ACSN:17496910;ACSN...
2907Q15139P00533NonestimulationCancerCellMap:10523301;CancerCellMap:2984676;C...
78053P00533P56945NoneinhibitionKEA:17570479;ProtMapper:15951569;SPIKE_LC:1714...
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71 rows × 5 columns

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" + ], + "text/plain": [ + " source target Type Effect \\\n", + "6821 P12931 Q05397 None stimulation \n", + "32968 P12931 P19022 None inhibition \n", + "5154 P12931 Q14289 None stimulation \n", + "44795 Q14289 Q05397 None stimulation \n", + "11582 P12931 P35222 None stimulation \n", + "... ... ... ... ... \n", + "67482 P00533 Q05397 None stimulation \n", + "7631 Q14289 P00533 None stimulation \n", + "73973 P00533 P35222 None stimulation \n", + "2907 Q15139 P00533 None stimulation \n", + "78053 P00533 P56945 None inhibition \n", + "\n", + " References \n", + "6821 Adhesome:10085298;Adhesome:10592173;Adhesome:1... \n", + "32968 ACSN:15782139;ACSN:16371504;ACSN:16492141;ACSN... \n", + "5154 Adhesome:10329689;Adhesome:10521452;Adhesome:1... \n", + "44795 Adhesome:16760434;HPRD:16760434;KEA:12960434;K... \n", + "11582 ACSN:10593980;ACSN:12123611;ACSN:15782139;ACSN... \n", + "... ... \n", + "67482 ACSN:10545505;ACSN:16919435;ACSN:17496910;ACSN... \n", + "7631 CA1:11274221;HPRD:10777553;InnateDB:14963038;S... \n", + "73973 ACSN:12040186;ACSN:14585353;ACSN:17496910;ACSN... \n", + "2907 CancerCellMap:10523301;CancerCellMap:2984676;C... \n", + "78053 KEA:17570479;ProtMapper:15951569;SPIKE_LC:1714... \n", + "\n", + "[71 rows x 5 columns]" + ] + }, + "execution_count": 15, + "metadata": {}, + "output_type": "execute_result" + } + ], + "source": [ + "#We can access to the edges of the network\n", + "new_net1.edges" + ] + }, + { + "cell_type": "code", + "execution_count": 13, + "id": "9540f33d-68f8-4c98-b68e-3e3d1497467e", + "metadata": {}, + "outputs": [ + { + "name": "stdout", + "output_type": "stream", + "text": [ + " Genesymbol in_tissue\n", + "0 SRC True\n", + "1 NOTCH1 True\n", + "2 PTK2 True\n", + "3 CDH1 True\n", + "4 CDH2 True\n", + "5 VIM True\n", + "6 MAP4K4 True\n", + "7 LATS1 True\n", + "8 LATS2 True\n", + "9 PTK2B True\n", + "10 CTNNB1 True\n", + "11 DAB1 True\n", + "12 MET True\n", + "13 PRKD1 True\n", + "14 CTNND1 True\n", + "15 PAK2 True\n", + "16 MAPK8 True\n", + "17 MAP3K7 True\n", + "18 MAP3K1 True\n", + "19 RAF1 True\n", + "20 STK3 True\n", + "21 STK4 True\n", + "22 NF2 True\n", + "23 SMAD3 True\n", + "24 BCAR1 True\n", + "25 LCK True\n", + "26 PTPRH True\n", + "27 WWTR1 True\n", + "28 YAP1 True\n", + "29 RUNX2 True\n", + "30 EGFR True\n" + ] + } + ], + "source": [ + "annot = Ontology()\n", + "#user_defined_tissue = 'breast cancer'\n", + "results_df = annot.check_tissue_annotations(genes_df = new_net1.nodes, tissue = 'colorectal cancer')\n", + "print(results_df)" + ] + }, + { + "cell_type": "code", + "execution_count": 12, + "id": "fbd98405-045a-4316-8174-e96e9a71d9ee", + "metadata": {}, + "outputs": [ + { + "data": { + "image/svg+xml": [ + "\n", + "\n", + "\n", + "\n", + "\n", + "\n", + "%3\n", + "\n", + "\n", + "\n", + "SRC\n", + "\n", + "SRC\n", + "\n", + "\n", + "\n", + "PTK2\n", + "\n", + "PTK2\n", + "\n", + "\n", + "\n", + "SRC->PTK2\n", + "\n", + "\n", + "\n", + "\n", + "\n", + "CDH2\n", + "\n", + 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"\n", + "\n", + "\n", + "\n", + "MAP3K7\n", + "\n", + "MAP3K7\n", + "\n", + "\n", + "\n", + "MAP3K7->MAPK8\n", + "\n", + "\n", + "\n", + "\n", + "\n", + "MAP3K7->SMAD3\n", + "\n", + "\n", + "\n", + "\n", + "\n", + "\n", + "MAP4K4\n", + "\n", + "MAP4K4\n", + "\n", + "\n", + "\n", + "MAP4K4->MAP3K7\n", + "\n", + "\n", + "\n", + "\n", + "\n", + "MAP3K1\n", + "\n", + "MAP3K1\n", + "\n", + "\n", + "\n", + "MAP4K4->MAP3K1\n", + "\n", + "\n", + "\n", + "\n", + "\n", + "MAP3K1->MAPK8\n", + "\n", + "\n", + "\n", + "\n", + "\n", + "STK3\n", + "\n", + "STK3\n", + "\n", + "\n", + "\n", + "RAF1->STK3\n", + "\n", + "\n", + "\n", + "\n", + "\n", + "\n", + "RAF1->STK4\n", + "\n", + "\n", + "\n", + "\n", + "\n", + "\n", + "LATS1\n", + "\n", + "LATS1\n", + "\n", + "\n", + "\n", + "STK3->LATS1\n", + "\n", + "\n", + "\n", + "\n", + "\n", + "LATS2\n", + "\n", + "LATS2\n", + "\n", + "\n", + "\n", + "STK3->LATS2\n", + "\n", + "\n", + "\n", + "\n", + "\n", + "WWTR1\n", + "\n", + "WWTR1\n", + "\n", + "\n", + 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+ "\n", + "\n", + "\n", + "\n", + "\n", + "LCK->RAF1\n", + "\n", + "\n", + "\n", + "\n", + "\n", + "PTPRH->SRC\n", + "\n", + "\n", + "\n", + "\n", + "\n", + "\n", + "PTPRH->PTK2\n", + "\n", + "\n", + "\n", + "\n", + "\n", + "\n", + "PTPRH->BCAR1\n", + "\n", + "\n", + "\n", + "\n", + "\n", + "\n", + "PTPRH->LCK\n", + "\n", + "\n", + "\n", + "\n", + "\n", + "\n", + "WWTR1->SMAD3\n", + "\n", + "\n", + "\n", + "\n", + "\n", + "WWTR1->RUNX2\n", + "\n", + "\n", + "\n", + "\n", + "\n", + "YAP1->CTNNB1\n", + "\n", + "\n", + "\n", + "\n", + "\n", + "YAP1->RUNX2\n", + "\n", + "\n", + "\n", + "\n", + "\n", + "\n", + "RUNX2->NOTCH1\n", + "\n", + "\n", + "\n", + "\n", + "\n", + "\n", + "EGFR->PTK2\n", + "\n", + "\n", + "\n", + "\n", + "\n", + "EGFR->CTNNB1\n", + "\n", + "\n", + "\n", + "\n", + "\n", + "EGFR->CTNND1\n", + "\n", + "\n", + "\n", + "\n", + "\n", + "\n", + "EGFR->BCAR1\n", + "\n", + "\n", + "\n", + "\n", + "\n", + "\n" + ], + "text/plain": [ + "" + ] + }, + "metadata": {}, + "output_type": "display_data" + } + ], + "source": [ + "network_visualizer = NetworkVisualizer(new_net1)\n", + "network_visualizer.tissue_mapping(results_df)\n", + "network_visualizer.render()" + ] + }, + { + "cell_type": "code", + "execution_count": 14, + "id": "6762228b-7e6c-4711-a07a-660c77f406e5", + "metadata": {}, + "outputs": [ + { + "data": { + "image/svg+xml": [ + "\n", + "\n", + "\n", + "\n", + "\n", + "\n", + "%3\n", + "\n", + "\n", + "\n", + "CDH1\n", + "\n", + "CDH1\n", + "\n", + "\n", + "\n", + "EGFR\n", + "\n", + "EGFR\n", + "\n", + "\n", + "\n", + "CDH1->EGFR\n", + "\n", + "\n", + "\n", + "\n", + "\n", + "CTNND1\n", + "\n", + "CTNND1\n", + "\n", + "\n", + "\n", + "EGFR->CTNND1\n", + "\n", + "\n", + "\n", + "\n", + "\n", + "\n", + "PTK2\n", + "\n", + "PTK2\n", + "\n", + "\n", + "\n", + "EGFR->PTK2\n", + "\n", + "\n", + "\n", + "\n", + "\n", + "CTNNB1\n", + "\n", + "CTNNB1\n", + "\n", + "\n", + "\n", + "EGFR->CTNNB1\n", + "\n", + "\n", + "\n", + "\n", + "\n", + "BCAR1\n", + "\n", + "BCAR1\n", + "\n", + "\n", + "\n", + "EGFR->BCAR1\n", + "\n", + "\n", + "\n", + "\n", + "\n", + "\n", + "SRC\n", + "\n", + "SRC\n", + "\n", + "\n", + "\n", + "SRC->EGFR\n", + "\n", + "\n", + "\n", + "\n", + "\n", + "PTK2B\n", + "\n", + "PTK2B\n", + "\n", + "\n", + "\n", + "PTK2B->EGFR\n", + "\n", + "\n", + "\n", + "\n", + "\n", + "PRKD1\n", + "\n", + "PRKD1\n", + "\n", + "\n", + "\n", + "PRKD1->EGFR\n", + "\n", + "\n", + "\n", + "\n", + "\n" + ], + "text/plain": [ + "" + ] + }, + "metadata": {}, + "output_type": "display_data" + } + ], + "source": [ + "visualizer = NetworkVisualizer(new_net1, predefined_node=\"EGFR\",color_by='effect')\n", + "visualizer.render()" + ] + }, + { + "cell_type": "markdown", + "id": "0e6e1986", + "metadata": {}, + "source": [ + "### Now we create the network with a similar list of genes but specifying the Resource object" + ] + }, + { + "cell_type": "code", + "execution_count": 15, + "id": "7401c535", + "metadata": {}, + "outputs": [], + "source": [ + "genes = [\"SRC\", \"NOTCH1\", \"PTK2\", \"CDH1\", \"CDH2\", \"VIM\", \"MAP4K4\", \"PTK2B\", \"COL1A1\"]" + ] + }, + { + "cell_type": "code", + "execution_count": 17, + "id": "60fcff6d", + "metadata": {}, + "outputs": [ + { + "name": "stdout", + "output_type": "stream", + "text": [ + "CPU times: user 22.9 ms, sys: 3.98 ms, total: 26.9 ms\n", + "Wall time: 25.7 ms\n" + ] + } + ], + "source": [ + "%%time\n", + "new_net1 = Network(genes, resources=resources.interactions)" + ] + }, + { + "cell_type": "code", + "execution_count": 18, + "id": "370180cc", + "metadata": { + "scrolled": true + }, + "outputs": [ + { + "name": "stdout", + "output_type": "stream", + "text": [ + "P12931 Q05397\n", + "P12830 P12931\n", + "P12931 P19022\n", + "P12931 Q14289\n", + "P02452 P12931\n", + "P46531 P19022\n", + "P46531 P02452\n", + "Q14289 Q05397\n", + "CPU times: user 1.34 s, sys: 19.9 ms, total: 1.36 s\n", + "Wall time: 1.36 s\n" + ] + } + ], + "source": [ + "%%time\n", + "new_net1.connect_nodes(only_signed=True, consensus_only=True)" + ] + }, + { + "cell_type": "code", + "execution_count": 19, + "id": "8ffecf5c", + "metadata": {}, + "outputs": [ + { + "name": "stdout", + "output_type": "stream", + "text": [ + "looking for paths in the network with length: 0 for node SRC and NOTCH1\n", + "looking for paths in the network with length: 1 for node SRC and NOTCH1\n", + "looking for paths in the network with length: 2 for node SRC and NOTCH1\n", + "Found a path!\n", + "[['SRC', 'COL1A1', 'NOTCH1']]\n", + "looking for paths in the network with length: 0 for node SRC and PTK2\n", + "looking for paths in the network with length: 1 for node SRC and PTK2\n", + "Found a path!\n", + "[['SRC', 'PTK2']]\n", + "looking for paths in the network with length: 0 for node SRC and CDH1\n", + "looking for paths in the network with length: 1 for node SRC and CDH1\n", + "Found a path!\n", + "[['SRC', 'CDH1']]\n", + "looking for paths in the network with length: 0 for node SRC and CDH2\n", + "looking for paths in the network with length: 1 for node SRC and CDH2\n", + "Found a path!\n", + "[['SRC', 'CDH2']]\n", + "looking for paths in the network with length: 0 for node SRC and VIM\n", + "looking for paths in the network with length: 1 for node SRC and VIM\n", + "looking for paths in the network with length: 2 for node SRC and VIM\n", + "looking for paths in the network with length: 3 for node SRC and VIM\n", + "i_search = 3\n", + "Looking for paths with length: 0 for node SRC and VIM\n", + "i_search = 3\n", + "Looking for paths with length: 1 for node SRC and VIM\n", + "i_search = 3\n", + "Looking for paths with length: 2 for node SRC and VIM\n", + "[['SRC', 'TCF7L2', 'VIM'], ['SRC', 'NFKB1', 'VIM'], ['SRC', 'HNF4A', 'VIM'], ['SRC', 'HIPK2', 'VIM'], ['SRC', 'STAT5A', 'VIM']]\n", + "P12931 Q9NQB0\n", + "Q9NQB0 P08670\n", + "P12931 P19838\n", + "P19838 P08670\n", + "P12931 P41235\n", + "P41235 P08670\n", + "P12931 Q9H2X6\n", + "Q9H2X6 P08670\n", + "P12931 P42229\n", + "P42229 P08670\n", + "P12931 Q05397\n", + "P12830 P12931\n", + "P12931 P19022\n", + "P12931 Q14289\n", + "P02452 P12931\n", + "P12931 Q9NQB0\n", + "P12931 P19838\n", + "P12931 P41235\n", + "P41235 P12931\n", + "P12931 Q9H2X6\n", + "P12931 P42229\n", + "P46531 P19022\n", + "P46531 P02452\n", + "P46531 P19838\n", + "Q14289 Q05397\n", + "Q9NQB0 P08670\n", + "P19838 P08670\n", + "P41235 P08670\n", + "Q9H2X6 P08670\n", + "P42229 P08670\n", + "P19838 P02452\n", + "P41235 Q9NQB0\n", + "P19838 P42229\n", + "looking for paths in the network with length: 0 for node SRC and MAP4K4\n", + "looking for paths in the network with length: 1 for node SRC and MAP4K4\n", + "looking for paths in the network with length: 2 for node SRC and MAP4K4\n", + "looking for paths in the network with length: 3 for node SRC and MAP4K4\n", + "i_search = 3\n", + "Looking for paths with length: 0 for node SRC and MAP4K4\n", + "i_search = 3\n", + "Looking for paths with length: 1 for node SRC and MAP4K4\n", + "i_search = 3\n", + "Looking for paths with length: 2 for node SRC and MAP4K4\n", + "[['SRC', 'EPHB1', 'MAP4K4'], ['SRC', 'PPARG', 'MAP4K4']]\n", + "P12931 P54762\n", + "P54762 O95819\n", + "P12931 P37231\n", + "P37231 O95819\n", + "P12931 Q05397\n", + "P12830 P12931\n", + "P12931 P19022\n", + "P12931 Q14289\n", + "P02452 P12931\n", + "P12931 Q9NQB0\n", + "P12931 P19838\n", + "P12931 P41235\n", + "P41235 P12931\n", + "P12931 Q9H2X6\n", + "P12931 P42229\n", + "P12931 P54762\n", + "P54762 P12931\n", + "P12931 P37231\n", + "P46531 P19022\n", + "P46531 P02452\n", + "P46531 P19838\n", + "P46531 P37231\n", + "Q14289 Q05397\n", + "P54762 Q05397\n", + "P37231 P12830\n", + "P37231 P19022\n", + "Q9NQB0 P08670\n", + "P19838 P08670\n", + "P41235 P08670\n", + "Q9H2X6 P08670\n", + "P42229 P08670\n", + "P54762 O95819\n", + "P37231 O95819\n", + "P19838 P02452\n", + "P41235 Q9NQB0\n", + "P19838 P42229\n", + "P37231 P19838\n", + "P37231 P42229\n", + "looking for paths in the network with length: 0 for node SRC and PTK2B\n", + "looking for paths in the network with length: 1 for node SRC and PTK2B\n", + "Found a path!\n", + "[['SRC', 'PTK2B']]\n", + "looking for paths in the network with length: 0 for node SRC and COL1A1\n", + "looking for paths in the network with length: 1 for node SRC and COL1A1\n", + "Found a path!\n", + "[['SRC', 'COL1A1']]\n", + "looking for paths in the network with length: 0 for node NOTCH1 and PTK2\n", + "looking for paths in the network with length: 1 for node NOTCH1 and PTK2\n", + "looking for paths in the network with length: 2 for node NOTCH1 and PTK2\n", + "looking for paths in the network with length: 3 for node NOTCH1 and PTK2\n", + "Found a path!\n", + "[['NOTCH1', 'COL1A1', 'SRC', 'PTK2']]\n", + "looking for paths in the network with length: 0 for node NOTCH1 and CDH1\n", + "looking for paths in the network with length: 1 for node NOTCH1 and CDH1\n", + "looking for paths in the network with length: 2 for node NOTCH1 and CDH1\n", + "Found a path!\n", + "[['NOTCH1', 'PPARG', 'CDH1']]\n", + "looking for paths in the network with length: 0 for node NOTCH1 and CDH2\n", + "looking for paths in the network with length: 1 for node NOTCH1 and CDH2\n", + "Found a path!\n", + "[['NOTCH1', 'CDH2']]\n", + "looking for paths in the network with length: 0 for node NOTCH1 and VIM\n", + "looking for paths in the network with length: 1 for node NOTCH1 and VIM\n", + "looking for paths in the network with length: 2 for node NOTCH1 and VIM\n", + "Found a path!\n", + "[['NOTCH1', 'NFKB1', 'VIM']]\n", + "looking for paths in the network with length: 0 for node NOTCH1 and MAP4K4\n", + "looking for paths in the network with length: 1 for node NOTCH1 and MAP4K4\n", + "looking for paths in the network with length: 2 for node NOTCH1 and MAP4K4\n", + "Found a path!\n", + "[['NOTCH1', 'PPARG', 'MAP4K4']]\n", + "looking for paths in the network with length: 0 for node NOTCH1 and PTK2B\n", + "looking for paths in the network with length: 1 for node NOTCH1 and PTK2B\n", + "looking for paths in the network with length: 2 for node NOTCH1 and PTK2B\n", + "looking for paths in the network with length: 3 for node NOTCH1 and PTK2B\n", + "Found a path!\n", + "[['NOTCH1', 'COL1A1', 'SRC', 'PTK2B']]\n", + "looking for paths in the network with length: 0 for node NOTCH1 and COL1A1\n", + "looking for paths in the network with length: 1 for node NOTCH1 and COL1A1\n", + "Found a path!\n", + "[['NOTCH1', 'COL1A1']]\n", + "looking for paths in the network with length: 0 for node PTK2 and CDH1\n", + "looking for paths in the network with length: 1 for node PTK2 and CDH1\n", + "looking for paths in the network with length: 2 for node PTK2 and CDH1\n", + "Found a path!\n", + "[['PTK2', 'SRC', 'CDH1']]\n", + "looking for paths in the network with length: 0 for node PTK2 and CDH2\n", + "looking for paths in the network with length: 1 for node PTK2 and CDH2\n", + "looking for paths in the network with length: 2 for node PTK2 and CDH2\n", + "looking for paths in the network with length: 3 for node PTK2 and CDH2\n", + "i_search = 3\n", + "Looking for paths with length: 0 for node PTK2 and CDH2\n", + "i_search = 3\n", + "Looking for paths with length: 1 for node PTK2 and CDH2\n", + "i_search = 3\n", + "Looking for paths with length: 2 for node PTK2 and CDH2\n", + "i_search = 3\n", + "Looking for paths with length: 3 for node PTK2 and CDH2\n", + "[['PTK2', 'ZYX', 'SRC', 'CDH2'], ['PTK2', 'STAT1', 'SMAD7', 'CDH2'], ['PTK2', 'STAT1', 'ABL1', 'CDH2'], ['PTK2', 'STAT1', 'JUN', 'CDH2'], ['PTK2', 'STAT1', 'MYC', 'CDH2'], ['PTK2', 'STAT1', 'COMPLEX:P19838_Q04206', 'CDH2'], ['PTK2', 'STAT1', 'WT1', 'CDH2'], ['PTK2', 'STAT1', 'MET', 'CDH2'], ['PTK2', 'ACTN3', 'SRC', 'CDH2'], ['PTK2', 'PIK3CG', 'AR', 'CDH2'], ['PTK2', 'MITF', 'MET', 'CDH2'], ['PTK2', 'MITF', 'PAX6', 'CDH2'], ['PTK2', 'IL6', 'MET', 'CDH2'], ['PTK2', 'CDC42', 'CTNND1', 'CDH2'], ['PTK2', 'ASAP1', 'AR', 'CDH2'], ['PTK2', 'RAP1B', 'CTNND1', 'CDH2'], ['PTK2', 'SMAD4', 'MSX1', 'CDH2'], ['PTK2', 'SMAD4', 'PPARG', 'CDH2'], ['PTK2', 'SMAD4', 'MYC', 'CDH2'], ['PTK2', 'SMAD4', 'SMAD7', 'CDH2'], ['PTK2', 'SMAD4', 'SOX9', 'CDH2'], ['PTK2', 'SMAD4', 'MET', 'CDH2'], ['PTK2', 'SMAD4', 'MMP2', 'CDH2'], ['PTK2', 'ITGB4', 'SRC', 'CDH2'], ['PTK2', 'ACTN4', 'SRC', 'CDH2'], ['PTK2', 'PTPN13', 'SRC', 'CDH2'], ['PTK2', 'PTPN13', 'MET', 'CDH2'], ['PTK2', 'TXN', 'PTPN1', 'CDH2'], ['PTK2', 'MAPK12', 'JUN', 'CDH2'], ['PTK2', 'MAPK12', 'MYC', 'CDH2'], ['PTK2', 'NCOA1', 'SRC', 'CDH2'], ['PTK2', 'NCOA1', 'STAT3', 'CDH2'], ['PTK2', 'NCOA1', 'PAWR', 'CDH2'], ['PTK2', 'NCOA1', 'MMP2', 'CDH2'], ['PTK2', 'ROCK1', 'RAC1', 'CDH2'], ['PTK2', 'ROCK1', 'CTNNB1', 'CDH2'], ['PTK2', 'MYCN', 'CTNNB1', 'CDH2'], ['PTK2', 'CEBPA', 'CTNNB1', 'CDH2'], ['PTK2', 'PIK3CB', 'PIK3R1', 'CDH2'], ['PTK2', 'PIK3CB', 'RHOA', 'CDH2'], ['PTK2', 'CAPN2', 'CTNNB1', 'CDH2'], ['PTK2', 'EPHB2', 'CTNNB1', 'CDH2'], ['PTK2', 'PIK3R5', 'RAC1', 'CDH2'], ['PTK2', 'CASP7', 'CTNNB1', 'CDH2'], ['PTK2', 'CDK5', 'RAC1', 'CDH2'], ['PTK2', 'ECM1', 'RAC1', 'CDH2'], ['PTK2', 'ECM1', 'CTNNB1', 'CDH2'], ['PTK2', 'KDR', 'RAC1', 'CDH2'], ['PTK2', 'SOS1', 'PIK3CA', 'CDH2'], ['PTK2', 'SOS1', 'RHOA', 'CDH2'], ['PTK2', 'VEGFA', 'RAC1', 'CDH2'], ['PTK2', 'VEGFA', 'CTNNB1', 'CDH2'], ['PTK2', 'ITGA4', 'RHOA', 'CDH2'], ['PTK2', 'EGFR', 'CDC42', 'CDH2'], ['PTK2', 'SDC4', 'MMP9', 'CDH2'], ['PTK2', 'PECAM1', 'FER', 'CDH2'], ['PTK2', 'PPARD', 'CTNNB1', 'CDH2'], ['PTK2', 'PIK3CG', 'PIK3R1', 'CDH2'], ['PTK2', 'RPS6KB1', 'PIK3R1', 'CDH2'], ['PTK2', 'PIK3R3', 'RAC1', 'CDH2'], ['PTK2', 'EFNA1', 'CTNNB1', 'CDH2'], ['PTK2', 'CASP3', 'CTNNB1', 'CDH2'], ['PTK2', 'PIK3CD', 'PIK3R1', 'CDH2'], ['PTK2', 'PIK3CD', 'RAC1', 'CDH2'], ['PTK2', 'CXCL12', 'CTNNB1', 'CDH2']]\n", + "Q05397 Q15942\n", + "Q15942 P12931\n", + "P12931 P19022\n", + "Q05397 P42224\n", + "P42224 O15105\n", + "O15105 P19022\n", + "Q05397 P42224\n", + "P42224 P00519\n", + "P00519 P19022\n", + "Q05397 P42224\n", + "P42224 P05412\n", + "P05412 P19022\n", + "Q05397 P42224\n", + "P42224 P01106\n", + "P01106 P19022\n", + "Q05397 P42224\n", + "P42224 COMPLEX:P19838_Q04206\n", + "COMPLEX:P19838_Q04206 P19022\n", + "Q05397 P42224\n", + "P42224 P19544\n", + "P19544 P19022\n", + "Q05397 P42224\n", + "P42224 P08581\n", + "P08581 P19022\n", + "Q05397 Q08043\n", + "Q08043 P12931\n", + "P12931 P19022\n", + "Q05397 P48736\n", + "P48736 P10275\n", + "P10275 P19022\n", + "Q05397 O75030\n", + "O75030 P08581\n", + "P08581 P19022\n", + "Q05397 O75030\n", + "O75030 P26367\n", + "P26367 P19022\n", + "Q05397 P05231\n", + "P05231 P08581\n", + "P08581 P19022\n", + "Q05397 P60953\n", + "P60953 O60716\n", + "O60716 P19022\n", + "Q05397 Q9ULH1\n", + "Q9ULH1 P10275\n", + "P10275 P19022\n", + "Q05397 P61224\n", + "P61224 O60716\n", + "O60716 P19022\n", + "Q05397 Q13485\n", + "Q13485 P28360\n", + "P28360 P19022\n", + "Q05397 Q13485\n", + "Q13485 P37231\n", + "P37231 P19022\n", + "Q05397 Q13485\n", + "Q13485 P01106\n", + "P01106 P19022\n", + "Q05397 Q13485\n", + "Q13485 O15105\n", + "O15105 P19022\n", + "Q05397 Q13485\n", + "Q13485 P48436\n", + "P48436 P19022\n", + "Q05397 Q13485\n", + "Q13485 P08581\n", + "P08581 P19022\n", + "Q05397 Q13485\n", + "Q13485 P08253\n", + "P08253 P19022\n", + "Q05397 P16144\n", + "P16144 P12931\n", + "P12931 P19022\n", + "Q05397 O43707\n", + "O43707 P12931\n", + "P12931 P19022\n", + "Q05397 Q12923\n", + "Q12923 P12931\n", + "P12931 P19022\n", + "Q05397 Q12923\n", + "Q12923 P08581\n", + "P08581 P19022\n", + "Q05397 P10599\n", + "P10599 P18031\n", + "P18031 P19022\n", + "Q05397 P53778\n", + "P53778 P05412\n", + "P05412 P19022\n", + "Q05397 P53778\n", + "P53778 P01106\n", + "P01106 P19022\n", + "Q05397 Q15788\n", + "Q15788 P12931\n", + "P12931 P19022\n", + "Q05397 Q15788\n", + "Q15788 P40763\n", + "P40763 P19022\n", + "Q05397 Q15788\n", + "Q15788 Q96IZ0\n", + "Q96IZ0 P19022\n", + "Q05397 Q15788\n", + "Q15788 P08253\n", + "P08253 P19022\n", + "Q13464 Q05397\n", + "P63000 Q13464\n", + "P19022 P63000\n", + "Q13464 Q05397\n", + "Q13464 P35222\n", + "P19022 P35222\n", + "P04198 Q05397\n", + "P35222 P04198\n", + "P19022 P35222\n", + "P49715 Q05397\n", + "P35222 P49715\n", + "P19022 P35222\n", + "Q05397 P42338\n", + "P27986 P42338\n", + "P19022 P27986\n", + "Q05397 P42338\n", + "P61586 P42338\n", + "P19022 P61586\n", + "P17655 Q05397\n", + "P35222 P17655\n", + "P19022 P35222\n", + "P29323 Q05397\n", + "P35222 P29323\n", + "P19022 P35222\n", + "Q05397 Q8WYR1\n", + "Q8WYR1 P63000\n", + "P19022 P63000\n", + "P55210 Q05397\n", + "P35222 P55210\n", + "P19022 P35222\n", + "Q00535 Q05397\n", + "P63000 Q00535\n", + "P19022 P63000\n", + "Q16610 Q05397\n", + "P63000 Q16610\n", + "P19022 P63000\n", + "Q16610 Q05397\n", + "P35222 Q16610\n", + "P19022 P35222\n", + "P35968 Q05397\n", + "P63000 P35968\n", + "P19022 P63000\n", + "Q07889 Q05397\n", + "Q07889 P42336\n", + "P19022 P42336\n", + "Q07889 Q05397\n", + "P61586 Q07889\n", + "P19022 P61586\n", + "P15692 Q05397\n", + "P15692 P63000\n", + "P19022 P63000\n", + "P15692 Q05397\n", + "P35222 P15692\n", + "P19022 P35222\n", + "P13612 Q05397\n", + "P61586 P13612\n", + "P19022 P61586\n", + "P00533 Q05397\n", + "P60953 P00533\n", + "P19022 P60953\n", + "P31431 Q05397\n", + "P14780 P31431\n", + "P19022 P14780\n", + "P16284 Q05397\n", + "P16591 P16284\n", + "P19022 P16591\n", + "Q03181 Q05397\n", + "P35222 Q03181\n", + "P19022 P35222\n", + "Q05397 P48736\n", + "P27986 P48736\n", + "P19022 P27986\n", + "P23443 Q05397\n", + "P23443 P27986\n", + "P19022 P27986\n", + "Q05397 Q92569\n", + "Q92569 P63000\n", + "P19022 P63000\n", + "P20827 Q05397\n", + "P35222 P20827\n", + "P19022 P35222\n", + "P42574 Q05397\n", + "P42574 P35222\n", + "P19022 P35222\n", + "Q05397 O00329\n", + "P27986 O00329\n", + "P19022 P27986\n", + "Q05397 O00329\n", + "O00329 P63000\n", + "P19022 P63000\n", + "P48061 Q05397\n", + "P35222 P48061\n", + "P19022 P35222\n", + "P12931 Q05397\n", + "P12830 P12931\n", + "P12931 P19022\n", + "P12931 Q14289\n", + "P02452 P12931\n", + "P12931 Q9NQB0\n", + "P12931 P19838\n", + "P12931 P41235\n", + "P41235 P12931\n", + "P12931 Q9H2X6\n", + "P12931 P42229\n", + "P12931 P54762\n", + "P54762 P12931\n", + "P12931 P37231\n", + "Q15942 P12931\n", + "P12931 P42224\n", + "P12931 P00519\n", + "P05412 P12931\n", + "COMPLEX:P19838_Q04206 P12931\n", + "P12931 P08581\n", + "Q08043 P12931\n", + "P12931 P10275\n", + "P10275 P12931\n", + "P12931 P60953\n", + "P12931 O60716\n", + "P12931 Q9ULH1\n", + "P12931 P08253\n", + "P12931 P16144\n", + "P16144 P12931\n", + "O43707 P12931\n", + "Q12923 P12931\n", + "P18031 P12931\n", + "Q15788 P12931\n", + "P12931 P40763\n", + "P12931 P63000\n", + "P12931 P35222\n", + "P12931 P42338\n", + "P12931 P61586\n", + "P17655 P12931\n", + "P29323 P12931\n", + "P12931 Q8WYR1\n", + "Q00535 P12931\n", + "P12931 P35968\n", + "P12931 Q07889\n", + "P12931 P42336\n", + "P15692 P12931\n", + "P13612 P12931\n", + "P12931 P00533\n", + "P12931 P14780\n", + "P12931 P16284\n", + "P12931 Q92569\n", + "P12931 P20827\n", + "P12931 O00329\n", + "P46531 P19022\n", + "P46531 P02452\n", + "P46531 P19838\n", + "P46531 P37231\n", + "P46531 P05412\n", + "P46531 P01106\n", + "COMPLEX:P19838_Q04206 P46531\n", + "P10275 P46531\n", + "P26367 P46531\n", + "P46531 P48436\n", + "P40763 P46531\n", + "P35222 P46531\n", + "P46531 P15692\n", + "P46531 P00533\n", + "P46531 P42574\n", + "Q14289 Q05397\n", + "P54762 Q05397\n", + "Q05397 Q15942\n", + "Q05397 P42224\n", + "COMPLEX:P19838_Q04206 Q05397\n", + "P08581 Q05397\n", + "Q05397 Q08043\n", + "Q05397 P48736\n", + "P48736 Q05397\n", + "Q05397 O75030\n", + "Q05397 P05231\n", + "Q05397 P60953\n", + "Q05397 Q9ULH1\n", + "Q05397 P61224\n", + "Q05397 Q13485\n", + "Q05397 P16144\n", + "P16144 Q05397\n", + "Q05397 O43707\n", + "Q05397 Q12923\n", + "Q05397 P10599\n", + "P18031 Q05397\n", + "Q05397 P53778\n", + "Q05397 Q15788\n", + "Q15788 Q05397\n", + "Q13464 Q05397\n", + "Q05397 P63000\n", + "P04198 Q05397\n", + "P49715 Q05397\n", + "Q05397 P42338\n", + "P42338 Q05397\n", + "Q05397 P27986\n", + "P61586 Q05397\n", + "P17655 Q05397\n", + "P29323 Q05397\n", + "Q05397 Q8WYR1\n", + "Q8WYR1 Q05397\n", + "P55210 Q05397\n", + "Q00535 Q05397\n", + "Q16610 Q05397\n", + "P35968 Q05397\n", + "Q07889 Q05397\n", + "Q05397 P42336\n", + "P15692 Q05397\n", + "P13612 Q05397\n", + "P00533 Q05397\n", + "P31431 Q05397\n", + "P16284 Q05397\n", + "Q03181 Q05397\n", + "P23443 Q05397\n", + "Q05397 Q92569\n", + "Q92569 Q05397\n", + "P20827 Q05397\n", + "P42574 Q05397\n", + "Q05397 O00329\n", + "O00329 Q05397\n", + "P48061 Q05397\n", + "P37231 P12830\n", + "P12830 Q15942\n", + "P05412 P12830\n", + "P01106 P12830\n", + "COMPLEX:P19838_Q04206 P12830\n", + "P19544 P12830\n", + "P08581 P12830\n", + "P10275 P12830\n", + "O75030 P12830\n", + "P60953 P12830\n", + "O60716 P12830\n", + "P61224 P12830\n", + "Q13485 P12830\n", + "P12830 P63000\n", + "P63000 P12830\n", + "P12830 P35222\n", + "P12830 P27986\n", + "P12830 P61586\n", + "P12830 P42336\n", + "P12830 P00533\n", + "P12830 P20827\n", + "P37231 P19022\n", + "O15105 P19022\n", 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"Q14289 P53778\n", + "Q14289 P40763\n", + "Q14289 P63000\n", + "P35968 Q14289\n", + "Q14289 Q07889\n", + "P42336 Q14289\n", + "P15692 Q14289\n", + "P13612 Q14289\n", + "Q14289 P00533\n", + "P19838 P02452\n", + "O15105 P02452\n", + "Q13485 P02452\n", + "P02452 P16144\n", + "P63000 P02452\n", + "P02452 P27986\n", + "P02452 P61586\n", + "P61586 P02452\n", + "P17655 P02452\n", + "P02452 P55210\n", + "P02452 Q07889\n", + "P02452 P42336\n", + "P02452 P13612\n", + "P02452 P31431\n", + "P02452 P42574\n", + "P41235 Q9NQB0\n", + "Q9NQB0 P05412\n", + "P05412 Q9NQB0\n", + "Q9NQB0 P01106\n", + "P10275 Q9NQB0\n", + "Q9NQB0 O75030\n", + "P26367 Q9NQB0\n", + "Q13485 Q9NQB0\n", + "Q9NQB0 P40763\n", + "Q9NQB0 P35222\n", + "P35222 Q9NQB0\n", + "Q9NQB0 P55210\n", + "Q9NQB0 P15692\n", + "Q9NQB0 Q03181\n", + "Q9NQB0 P42574\n", + "Q9NQB0 P48061\n", + "P19838 P42229\n", + "P37231 P19838\n", + "P19838 P05412\n", + "P19838 P01106\n", + "COMPLEX:P19838_Q04206 P19838\n", + "P19838 P19544\n", + "P19838 P10275\n", + "P19838 P05231\n", + "P19838 P08253\n", + "P19838 Q12923\n", + "P10599 P19838\n", + "P63000 P19838\n", + "P27986 P19838\n", + "P19838 P35968\n", + "P42336 P19838\n", + "P19838 P15692\n", + "P19838 P00533\n", + "P00533 P19838\n", + "P19838 P14780\n", + "P41235 P01106\n", + "COMPLEX:P19838_Q04206 P41235\n", + "P41235 P10275\n", + "P41235 P63000\n", + "P35222 P41235\n", + "P41235 P49715\n", + "P00519 Q9H2X6\n", + "Q9H2X6 P26367\n", + "P26367 Q9H2X6\n", + "Q9H2X6 P15692\n", + "P37231 P42229\n", + "P42229 P00519\n", + "P00519 P42229\n", + "P42229 P01106\n", + "COMPLEX:P19838_Q04206 P42229\n", + "P42229 P10275\n", + "P10275 P42229\n", + "P18031 P42229\n", + "Q15788 P42229\n", + "P42229 P49715\n", + "P00533 P42229\n", + "P16591 P42229\n", + "P42229 O00329\n", + "P48061 P42229\n", + "P26367 P54762\n", + "Q12923 P54762\n", + "P54762 P63000\n", + "P54762 P27986\n", + "P54762 P42336\n", + "P00519 P37231\n", + "P37231 P05412\n", + "P37231 P01106\n", + "COMPLEX:P19838_Q04206 P37231\n", + "Q13485 P37231\n", + "P37231 P08253\n", + "P37231 P40763\n", + "P37231 P35222\n", + "P35222 P37231\n", + "P49715 P37231\n", + "P37231 P35968\n", + "P37231 P00533\n", + "P37231 P14780\n", + "Q03181 P37231\n", + "P19544 Q15942\n", + "O60716 Q15942\n", + "P35222 Q15942\n", + "Q15942 P27986\n", + "Q15942 P61586\n", + "Q00535 Q15942\n", + "Q15942 P42336\n", + "P42224 O15105\n", + "P42224 P00519\n", + "P00519 P42224\n", + "P42224 P05412\n", + "P42224 P01106\n", + "P42224 COMPLEX:P19838_Q04206\n", + "P42224 P19544\n", + "P42224 P08581\n", + "P10275 P42224\n", + "P42224 P05231\n", + "P05231 P42224\n", + "P53778 P42224\n", + "P40763 P42224\n", + "P29323 P42224\n", + "P42224 P15692\n", + "P42224 P00533\n", + "P00533 P42224\n", + "P42224 P14780\n", + "P48061 P42224\n", + "P05412 O15105\n", + "P01106 O15105\n", + "COMPLEX:P19838_Q04206 O15105\n", + "O15105 P08581\n", + "O15105 P05231\n", + "Q13485 O15105\n", + "O15105 P08253\n", + "O15105 P35222\n", + "P35222 O15105\n", + "O15105 P15692\n", + "O15105 P14780\n", + "P00519 P05412\n", + "P05412 P00519\n", + "P01106 P00519\n", + "COMPLEX:P19838_Q04206 P00519\n", + "P00519 P08581\n", + "P00519 O60716\n", + "P18031 P00519\n", + "P00519 P40763\n", + "P00519 P63000\n", + "P00519 P35222\n", + "P00519 P29323\n", + "P00519 Q00535\n", + "P00519 Q07889\n", + "P00519 P00533\n", + "P00519 P48061\n", + "P05412 P01106\n", + "COMPLEX:P19838_Q04206 P05412\n", + "P05412 P08581\n", + "P10275 P05412\n", + "P05412 O75030\n", + "P05412 P05231\n", + "P05412 Q13485\n", + "P05412 P08253\n", + "P05412 P10599\n", + "P05412 P53778\n", + "P53778 P05412\n", + "P05412 P63000\n", + "P05412 P35222\n", + "P35222 P05412\n", + "P49715 P05412\n", + "P05412 P27986\n", + "P05412 P29323\n", + "P05412 P15692\n", + "P05412 P00533\n", + "P05412 P14780\n", + "P05412 Q03181\n", + "P05412 P42574\n", + "P05412 P48061\n", + "COMPLEX:P19838_Q04206 P01106\n", + "P19544 P01106\n", + "P01106 P08581\n", + "Q13485 P01106\n", + "P01106 P48436\n", + "P01106 P08253\n", + "P01106 P16144\n", + "P01106 P10599\n", + "P53778 P01106\n", + "P40763 P01106\n", + "P63000 P01106\n", + "P35222 P01106\n", + "P01106 P04198\n", + "P04198 P01106\n", + "P01106 P49715\n", + "P49715 P01106\n", + "P01106 P27986\n", + "P27986 P01106\n", + "P01106 P61586\n", + "P01106 P29323\n", + "P01106 Q00535\n", + "P42336 P01106\n", + "P01106 P15692\n", + "P01106 P13612\n", + "P01106 P14780\n", + "P23443 P01106\n", + "P01106 O00329\n", + "P01106 P48061\n", + "COMPLEX:P19838_Q04206 P19544\n", + "COMPLEX:P19838_Q04206 P08581\n", + "COMPLEX:P19838_Q04206 P10275\n", + "COMPLEX:P19838_Q04206 P05231\n", + "COMPLEX:P19838_Q04206 P60953\n", + "COMPLEX:P19838_Q04206 P28360\n", + "COMPLEX:P19838_Q04206 P48436\n", + "COMPLEX:P19838_Q04206 P08253\n", + "COMPLEX:P19838_Q04206 Q12923\n", + "COMPLEX:P19838_Q04206 P18031\n", + "COMPLEX:P19838_Q04206 Q13464\n", + "COMPLEX:P19838_Q04206 P35222\n", + "COMPLEX:P19838_Q04206 P49715\n", + "COMPLEX:P19838_Q04206 P27986\n", + "COMPLEX:P19838_Q04206 P29323\n", + "COMPLEX:P19838_Q04206 P55210\n", + "COMPLEX:P19838_Q04206 P35968\n", + "COMPLEX:P19838_Q04206 P42336\n", + "COMPLEX:P19838_Q04206 P15692\n", + "COMPLEX:P19838_Q04206 P00533\n", + "COMPLEX:P19838_Q04206 P31431\n", + "COMPLEX:P19838_Q04206 P14780\n", + "COMPLEX:P19838_Q04206 P16284\n", + "COMPLEX:P19838_Q04206 P48061\n", + "P19544 P10275\n", + "Q96IZ0 P19544\n", + "P19544 P04198\n", + "P19544 P13612\n", + "P19544 P00533\n", + "P19544 P14780\n", + "Q03181 P19544\n", + "P08581 P48736\n", + "P10275 P08581\n", + "O75030 P08581\n", + "P26367 P08581\n", + "P05231 P08581\n", + "P08581 P60953\n", + "P08581 O60716\n", + "Q13485 P08581\n", + "Q12923 P08581\n", + "P18031 P08581\n", + "P08581 P40763\n", + "P08581 P35222\n", + "P08581 P42338\n", + "P08581 P27986\n", + "P08581 Q8WYR1\n", + "P08581 P42336\n", + "P15692 P08581\n", + "P08581 P23443\n", + "P08581 Q92569\n", + "P08581 O00329\n", + "P63000 Q08043\n", + "Q08043 P27986\n", + "Q08043 P61586\n", + "P61586 Q08043\n", + "Q08043 P42336\n", + "P48736 P10275\n", + "P16144 P48736\n", + "P48736 P63000\n", + "P27986 P48736\n", + "P35968 P48736\n", + "P00533 P48736\n", + "P48061 P48736\n", + "P26367 P10275\n", + "P10275 P05231\n", + "P10275 P60953\n", + "P10275 Q9ULH1\n", + "Q9ULH1 P10275\n", + "Q13485 P10275\n", + "P10275 P08253\n", + "P10275 P10599\n", + "P10275 P18031\n", + "Q15788 P10275\n", + "P10275 P35222\n", + "P10275 P42338\n", + "P10275 P27986\n", + "P55210 P10275\n", + "P10275 Q00535\n", + "Q00535 P10275\n", + "P10275 P15692\n", + "P10275 P00533\n", + "P16591 P10275\n", + "P10275 P20827\n", + "P42574 P10275\n", + "O75030 P26367\n", + "P26367 O75030\n", + "P05231 O75030\n", + "P48436 O75030\n", + "P35222 O75030\n", + "O75030 P15692\n", + "O75030 P13612\n", + "P26367 O60716\n", + "P26367 P08253\n", + "P26367 P15692\n", + "P26367 P13612\n", + "P26367 P14780\n", + "Q15788 P05231\n", + "P05231 P40763\n", + "P35222 P05231\n", + "P04198 P05231\n", + "P49715 P05231\n", + "P05231 P35968\n", + "P05231 Q07889\n", + "P05231 P15692\n", + "P15692 P05231\n", + "P05231 P14780\n", + "Q03181 P05231\n", + "P05231 P48061\n", + "P60953 O60716\n", + "P61224 P60953\n", + "P60953 P53778\n", + "P60953 P35222\n", + "P35222 P60953\n", + "P04198 P60953\n", + "P60953 P27986\n", + "P27986 P60953\n", + "P29323 P60953\n", + "P35968 P60953\n", + "P42336 P60953\n", + "P15692 P60953\n", + "P60953 P00533\n", + "P60953 P23443\n", + "P48061 P60953\n", + "P61224 O60716\n", + "P18031 O60716\n", + "O60716 P63000\n", + "O60716 P27986\n", + "O60716 P61586\n", + "O60716 P42336\n", + "P00533 O60716\n", + "P16591 O60716\n", + "O60716 P20827\n", + "Q9ULH1 P63000\n", + "Q9ULH1 P61586\n", + "P61224 P63000\n", + "P61224 P35222\n", + "P61224 P27986\n", + "P61224 P61586\n", + "P61224 P42336\n", + "P61224 P13612\n", + "Q13485 P28360\n", + "Q13485 P48436\n", + "Q13485 P08253\n", + "Q15788 Q13485\n", + "Q13485 P04198\n", + "Q00535 Q13485\n", + "Q13485 P15692\n", + "Q13485 P00533\n", + "Q13485 Q03181\n", + "Q13485 P48061\n", + "P35222 P28360\n", + "Q13464 P48436\n", + "P48436 P35222\n", + "P48436 P42336\n", + "P48436 P15692\n", + "Q15788 P08253\n", + "P63000 P08253\n", + "P35222 P08253\n", + "P04198 P08253\n", + "P08253 P00533\n", + "P16144 P42338\n", + "P16144 P27986\n", + "P17655 P16144\n", + "P55210 P16144\n", + "P16144 P42336\n", + "P42574 P16144\n", + "P16144 O00329\n", + "P63000 O43707\n", + "O43707 P27986\n", + "O43707 P61586\n", + "P61586 O43707\n", + "O43707 P42336\n", + "P40763 Q12923\n", + "Q12923 P29323\n", + "P10599 P18031\n", + "P18031 P40763\n", + "P18031 P35222\n", + "P18031 P27986\n", + "P61586 P18031\n", + "P17655 P18031\n", + "P18031 P42336\n", + "P00533 P18031\n", + "P16591 P18031\n", + "P53778 P49715\n", + "Q00535 P53778\n", + "Q15788 P40763\n", + "Q15788 Q96IZ0\n", + "Q15788 P15692\n", + "Q15788 P00533\n", + "P63000 P40763\n", + "P40763 P35222\n", + "P49715 P40763\n", + "P40763 P27986\n", + "P27986 P40763\n", + "Q00535 P40763\n", + "P42336 P40763\n", + "P40763 P15692\n", + "P00533 P40763\n", + "P40763 P14780\n", + "P16591 P40763\n", + "P40763 P42574\n", + "P40763 P48061\n", + "P48061 P40763\n", + "P63000 Q13464\n", + "Q13464 P35222\n", + "P35222 Q13464\n", + "P61586 Q13464\n", + "P42574 Q13464\n", + "P48061 Q13464\n", + "P63000 P35222\n", + "P63000 P42338\n", + "P27986 P63000\n", + "P63000 P61586\n", + "P29323 P63000\n", + "P63000 Q8WYR1\n", + "Q8WYR1 P63000\n", + "P63000 Q00535\n", + "P63000 Q16610\n", + "P63000 P35968\n", + "Q07889 P63000\n", + "P63000 P42336\n", + "P42336 P63000\n", + "P63000 P15692\n", + "P15692 P63000\n", + "P13612 P63000\n", + "P00533 P63000\n", + "P31431 P63000\n", + "P63000 Q92569\n", + "Q92569 P63000\n", + "P20827 P63000\n", + "P63000 O00329\n", + "O00329 P63000\n", + "P48061 P63000\n", + "P35222 P04198\n", + "P35222 P49715\n", + "P35222 P27986\n", + "P35222 P61586\n", + "P35222 P17655\n", + "P35222 P29323\n", + "P35222 P55210\n", + "P35222 Q16610\n", + "P35222 P42336\n", + "P35222 P15692\n", + "P00533 P35222\n", + "P35222 P14780\n", + "P16591 P35222\n", + "P35222 Q03181\n", + "P35222 P20827\n", + "P35222 P42574\n", + "P42574 P35222\n", + "P35222 P48061\n", + "P04198 P00533\n", + "Q03181 P49715\n", + "P27986 P42338\n", + "P61586 P42338\n", + "P35968 P42338\n", + "P42338 Q07889\n", + "P00533 P42338\n", + "Q92569 P42338\n", + "P48061 P42338\n", + "P27986 P61586\n", + "P61586 P27986\n", + "P29323 P27986\n", + "P35968 P27986\n", + "P27986 Q07889\n", + "P15692 P27986\n", + "P00533 P27986\n", + "P27986 P23443\n", + "P23443 P27986\n", + "P27986 O00329\n", + "P48061 P27986\n", + "P17655 P61586\n", + "P61586 Q07889\n", + "P61586 P42336\n", + "P42336 P61586\n", + "P61586 P13612\n", + "P00533 P61586\n", + "P61586 P14780\n", + "P20827 P61586\n", + "P42574 P61586\n", + "P29323 P42336\n", + "P48061 P29323\n", + "P35968 Q8WYR1\n", + "P00533 Q8WYR1\n", + "P48061 Q8WYR1\n", + "P42574 P55210\n", + "P35968 Q07889\n", + "P35968 P42336\n", + "P15692 P35968\n", + "P35968 P16284\n", + "P35968 Q92569\n", + "P35968 O00329\n", + "Q07889 P42336\n", + "P42336 Q07889\n", + "P15692 Q07889\n", + "P00533 Q07889\n", + "Q92569 Q07889\n", + "O00329 Q07889\n", + "P15692 P42336\n", + "P00533 P42336\n", + "P42336 P23443\n", + "Q92569 P42336\n", + "P48061 P42336\n", + "P15692 P00533\n", + "P15692 P14780\n", + "P00533 P14780\n", + "P00533 Q92569\n", + "P00533 O00329\n", + "P14780 P31431\n", + "Q03181 P14780\n", + "P23443 P14780\n", + "P48061 P14780\n", + "P16591 P16284\n", + "P48061 Q92569\n", + "P48061 O00329\n", + "looking for paths in the network with length: 0 for node PTK2 and VIM\n", + "looking for paths in the network with length: 1 for node PTK2 and VIM\n", + "looking for paths in the network with length: 2 for node PTK2 and VIM\n", + "looking for paths in the network with length: 3 for node PTK2 and VIM\n", + "Found a path!\n", + "[['PTK2', 'MAPK12', 'JUN', 'VIM'], ['PTK2', 'PIK3R1', 'STAT3', 'VIM'], ['PTK2', 'PIK3R1', 'NFKB1', 'VIM'], ['PTK2', 'IL6', 'STAT3', 'VIM'], ['PTK2', 'CDC42', 'CTNNB1', 'VIM'], ['PTK2', 'NCOA1', 'STAT5A', 'VIM'], ['PTK2', 'NCOA1', 'STAT3', 'VIM'], ['PTK2', 'NCOA1', 'PAWR', 'VIM'], ['PTK2', 'RAC1', 'ROCK1', 'VIM'], ['PTK2', 'RAC1', 'NFKB1', 'VIM'], ['PTK2', 'RAC1', 'STAT3', 'VIM'], ['PTK2', 'RAC1', 'CTNNB1', 'VIM'], ['PTK2', 'RAP1B', 'CTNNB1', 'VIM'], ['PTK2', 'SMAD4', 'TCF7L2', 'VIM'], ['PTK2', 'PIK3CA', 'STAT3', 'VIM'], ['PTK2', 'PIK3CA', 'NFKB1', 'VIM'], ['PTK2', 'STAT1', 'JUN', 'VIM'], ['PTK2', 'STAT1', 'COMPLEX:P19838_Q04206', 'VIM'], ['PTK2', 'TXN', 'NFKB1', 'VIM']]\n", + "looking for paths in the network with length: 0 for node PTK2 and MAP4K4\n", + "looking for paths in the network with length: 1 for node PTK2 and MAP4K4\n", + "looking for paths in the network with length: 2 for node PTK2 and MAP4K4\n", + "looking for paths in the network with length: 3 for node PTK2 and MAP4K4\n", + "Found a path!\n", + "[['PTK2', 'PTPN13', 'EPHB1', 'MAP4K4'], ['PTK2', 'PTPN13', 'EPHB2', 'MAP4K4'], ['PTK2', 'SMAD4', 'PPARG', 'MAP4K4']]\n", + "looking for paths in the network with length: 0 for node PTK2 and PTK2B\n", + "looking for paths in the network with length: 1 for node PTK2 and PTK2B\n", + "Found a path!\n", + "[['PTK2', 'PTK2B']]\n", + "looking for paths in the network with length: 0 for node PTK2 and COL1A1\n", + "looking for paths in the network with length: 1 for node PTK2 and COL1A1\n", + "looking for paths in the network with length: 2 for node PTK2 and COL1A1\n", + "Found a path!\n", + "[['PTK2', 'RAC1', 'COL1A1'], ['PTK2', 'SMAD4', 'COL1A1'], ['PTK2', 'SRC', 'COL1A1'], ['PTK2', 'CASP7', 'COL1A1'], ['PTK2', 'RHOA', 'COL1A1'], ['PTK2', 'ITGA4', 'COL1A1'], ['PTK2', 'SDC4', 'COL1A1'], ['PTK2', 'ITGB4', 'COL1A1'], ['PTK2', 'CASP3', 'COL1A1'], ['PTK2', 'SOS1', 'COL1A1']]\n", + "looking for paths in the network with length: 0 for node CDH1 and CDH2\n", + "looking for paths in the network with length: 1 for node CDH1 and CDH2\n", + "looking for paths in the network with length: 2 for node CDH1 and CDH2\n", + "Found a path!\n", + "[['CDH1', 'SRC', 'CDH2'], ['CDH1', 'RAC1', 'CDH2'], ['CDH1', 'CDC42', 'CDH2']]\n", + "looking for paths in the network with length: 0 for node CDH1 and VIM\n", + "looking for paths in the network with length: 1 for node CDH1 and VIM\n", + "looking for paths in the network with length: 2 for node CDH1 and VIM\n", + "Found a path!\n", + "[['CDH1', 'CTNNB1', 'VIM']]\n", + "looking for paths in the network with length: 0 for node CDH1 and MAP4K4\n", + "looking for paths in the network with length: 1 for node CDH1 and MAP4K4\n", + "looking for paths in the network with length: 2 for node CDH1 and MAP4K4\n", + "looking for paths in the network with length: 3 for node CDH1 and MAP4K4\n", + "Found a path!\n", + "[['CDH1', 'SRC', 'EPHB1', 'MAP4K4'], ['CDH1', 'SRC', 'PPARG', 'MAP4K4'], ['CDH1', 'CTNNB1', 'EPHB2', 'MAP4K4'], ['CDH1', 'CTNNB1', 'PPARG', 'MAP4K4']]\n", + "looking for paths in the network with length: 0 for node CDH1 and PTK2B\n", + "looking for paths in the network with length: 1 for node CDH1 and PTK2B\n", + "looking for paths in the network with length: 2 for node CDH1 and PTK2B\n", + "Found a path!\n", + "[['CDH1', 'SRC', 'PTK2B'], ['CDH1', 'PIK3CA', 'PTK2B'], ['CDH1', 'RAC1', 'PTK2B']]\n", + "looking for paths in the network with length: 0 for node CDH1 and COL1A1\n", + "looking for paths in the network with length: 1 for node CDH1 and COL1A1\n", + "looking for paths in the network with length: 2 for node CDH1 and COL1A1\n", + "Found a path!\n", + "[['CDH1', 'RAC1', 'COL1A1'], ['CDH1', 'RHOA', 'COL1A1']]\n", + "looking for paths in the network with length: 0 for node CDH2 and VIM\n", + "looking for paths in the network with length: 1 for node CDH2 and VIM\n", + "looking for paths in the network with length: 2 for node CDH2 and VIM\n", + "Found a path!\n", + "[['CDH2', 'CTNNB1', 'VIM']]\n", + "looking for paths in the network with length: 0 for node CDH2 and MAP4K4\n", + "looking for paths in the network with length: 1 for node CDH2 and MAP4K4\n", + "looking for paths in the network with length: 2 for node CDH2 and MAP4K4\n", + "looking for paths in the network with length: 3 for node CDH2 and MAP4K4\n", + "Found a path!\n", + "[['CDH2', 'CTNNB1', 'EPHB2', 'MAP4K4'], ['CDH2', 'CTNNB1', 'PPARG', 'MAP4K4']]\n", + "looking for paths in the network with length: 0 for node CDH2 and PTK2B\n", + "looking for paths in the network with length: 1 for node CDH2 and PTK2B\n", + "looking for paths in the network with length: 2 for node CDH2 and PTK2B\n", + "Found a path!\n", + "[['CDH2', 'PIK3CA', 'PTK2B'], ['CDH2', 'STAT3', 'PTK2B']]\n", + "looking for paths in the network with length: 0 for node CDH2 and COL1A1\n", + "looking for paths in the network with length: 1 for node CDH2 and COL1A1\n", + "looking for paths in the network with length: 2 for node CDH2 and COL1A1\n", + "Found a path!\n", + "[['CDH2', 'RAC1', 'COL1A1'], ['CDH2', 'RHOA', 'COL1A1'], ['CDH2', 'SRC', 'COL1A1']]\n", + "looking for paths in the network with length: 0 for node VIM and MAP4K4\n", + "looking for paths in the network with length: 1 for node VIM and MAP4K4\n", + "looking for paths in the network with length: 2 for node VIM and MAP4K4\n", + "looking for paths in the network with length: 3 for node VIM and MAP4K4\n", + "i_search = 3\n", + "Looking for paths with length: 0 for node VIM and MAP4K4\n", + "i_search = 3\n", + "Looking for paths with length: 1 for node VIM and MAP4K4\n", + "i_search = 3\n", + "Looking for paths with length: 2 for node VIM and MAP4K4\n", + "i_search = 3\n", + "Looking for paths with length: 3 for node VIM and MAP4K4\n", + "[['VIM', 'TGFB1', 'TNF', 'MAP4K4'], ['VIM', 'COMPLEX:P19838_Q04206', 'IKBKB', 'MAP4K4'], ['VIM', 'COMPLEX:P19838_Q04206', 'IKBKE', 'MAP4K4'], ['VIM', 'COMPLEX:P19838_Q04206', 'IKBKG', 'MAP4K4'], ['VIM', 'COMPLEX:P19838_Q04206', 'CHUK', 'MAP4K4'], ['VIM', 'TP63', 'IKBKB', 'MAP4K4'], ['VIM', 'AKT1', 'TNF', 'MAP4K4'], ['VIM', 'COMPLEX:Q04206_Q04864', 'IKBKE', 'MAP4K4'], ['VIM', 'COMPLEX:Q00653_Q01201', 'CHUK', 'MAP4K4'], ['VIM', 'MAPKAPK2', 'TNF', 'MAP4K4'], ['VIM', 'JUN', 'MAP3K3', 'MAP4K4'], ['VIM', 'CASP3', 'TNF', 'MAP4K4'], ['VIM', 'PLK1', 'MAP3K8', 'MAP4K4'], ['VIM', 'IRF6', 'TNF', 'MAP4K4'], ['VIM', 'NFKB1', 'IKBKG', 'MAP4K4'], ['VIM', 'NFKB1', 'MAP3K2', 'MAP4K4'], ['VIM', 'NFKB1', 'IKBKE', 'MAP4K4'], ['VIM', 'NFKB1', 'MAP3K3', 'MAP4K4']]\n", + "P01137 P08670\n", + "P01375 P01137\n", + "P01375 O95819\n", + "COMPLEX:P19838_Q04206 P08670\n", + "O14920 COMPLEX:P19838_Q04206\n", + "O95819 O14920\n", + "COMPLEX:P19838_Q04206 P08670\n", + "COMPLEX:P19838_Q04206 Q14164\n", + "O95819 Q14164\n", + "COMPLEX:P19838_Q04206 P08670\n", + "Q9Y6K9 COMPLEX:P19838_Q04206\n", + "O95819 Q9Y6K9\n", + "COMPLEX:P19838_Q04206 P08670\n", + "O15111 COMPLEX:P19838_Q04206\n", + "O95819 O15111\n", + "Q9H3D4 P08670\n", + "O14920 Q9H3D4\n", + "O95819 O14920\n", + "P31749 P08670\n", + "P01375 P31749\n", + "P01375 O95819\n", + "COMPLEX:Q04206_Q04864 P08670\n", + "COMPLEX:Q04206_Q04864 Q14164\n", + "O95819 Q14164\n", + "COMPLEX:Q00653_Q01201 P08670\n", + "O15111 COMPLEX:Q00653_Q01201\n", + "O95819 O15111\n", + "P49137 P08670\n", + "P01375 P49137\n", + "P01375 O95819\n", + "P05412 P08670\n", + "Q99759 P05412\n", + "O95819 Q99759\n", + "P42574 P08670\n", + "P01375 P42574\n", + "P01375 O95819\n", + "P53350 P08670\n", + "P41279 P53350\n", + "O95819 P41279\n", + "O14896 P08670\n", + "O14896 P01375\n", + "P01375 O95819\n", + "P19838 P08670\n", + "P19838 Q9Y6K9\n", + "O95819 Q9Y6K9\n", + "P19838 P08670\n", + "Q9Y2U5 P19838\n", + "O95819 Q9Y2U5\n", + "P19838 P08670\n", + "Q14164 P19838\n", + "O95819 Q14164\n", + "P19838 P08670\n", + "Q99759 P19838\n", + "O95819 Q99759\n", + "P12931 Q05397\n", + "P12830 P12931\n", + "P12931 P19022\n", + "P12931 Q14289\n", + "P02452 P12931\n", + "P12931 Q9NQB0\n", + "P12931 P19838\n", + "P12931 P41235\n", + "P41235 P12931\n", + "P12931 Q9H2X6\n", + "P12931 P42229\n", + "P12931 P54762\n", + "P54762 P12931\n", + "P12931 P37231\n", + "Q15942 P12931\n", + "P12931 P42224\n", + "P12931 P00519\n", + "P05412 P12931\n", + "COMPLEX:P19838_Q04206 P12931\n", + "P12931 P08581\n", + "Q08043 P12931\n", + "P12931 P10275\n", + "P10275 P12931\n", + "P12931 P60953\n", + "P12931 O60716\n", + "P12931 Q9ULH1\n", + "P12931 P08253\n", + "P12931 P16144\n", + "P16144 P12931\n", + "O43707 P12931\n", + "Q12923 P12931\n", + "P18031 P12931\n", + "Q15788 P12931\n", + "P12931 P40763\n", + "P12931 P63000\n", + "P12931 P35222\n", + "P12931 P42338\n", + "P12931 P61586\n", + "P17655 P12931\n", + "P29323 P12931\n", + "P12931 Q8WYR1\n", + "Q00535 P12931\n", + "P12931 P35968\n", + "P12931 Q07889\n", + "P12931 P42336\n", + "P15692 P12931\n", + "P13612 P12931\n", + "P12931 P00533\n", + "P12931 P14780\n", + "P12931 P16284\n", + "P12931 Q92569\n", + "P12931 P20827\n", + "P12931 O00329\n", + "P12931 O14920\n", + "P12931 O15111\n", + "P12931 P31749\n", + "COMPLEX:Q04206_Q04864 P12931\n", + "COMPLEX:Q00653_Q01201 P12931\n", + "P12931 Q9Y2U5\n", + "P46531 P19022\n", + "P46531 P02452\n", + "P46531 P19838\n", + "P46531 P37231\n", + "P46531 P05412\n", + "P46531 P01106\n", + "COMPLEX:P19838_Q04206 P46531\n", + "P10275 P46531\n", + "P26367 P46531\n", + "P46531 P48436\n", + "P40763 P46531\n", + "P35222 P46531\n", + "P46531 P15692\n", + "P46531 P00533\n", + "P46531 P42574\n", + "P46531 O15111\n", + "Q9H3D4 P46531\n", + "COMPLEX:Q04206_Q04864 P46531\n", + "COMPLEX:Q00653_Q01201 P46531\n", + "Q14289 Q05397\n", + "P54762 Q05397\n", + "Q05397 Q15942\n", + "Q05397 P42224\n", + "COMPLEX:P19838_Q04206 Q05397\n", + "P08581 Q05397\n", + "Q05397 Q08043\n", + "Q05397 P48736\n", + "P48736 Q05397\n", + "Q05397 O75030\n", + "Q05397 P05231\n", + "Q05397 P60953\n", + "Q05397 Q9ULH1\n", + "Q05397 P61224\n", + "Q05397 Q13485\n", + "Q05397 P16144\n", + "P16144 Q05397\n", + "Q05397 O43707\n", + "Q05397 Q12923\n", + "Q05397 P10599\n", + "P18031 Q05397\n", + "Q05397 P53778\n", + "Q05397 Q15788\n", + "Q15788 Q05397\n", + "Q13464 Q05397\n", + "Q05397 P63000\n", + "P04198 Q05397\n", + "P49715 Q05397\n", + "Q05397 P42338\n", + "P42338 Q05397\n", + "Q05397 P27986\n", + "P61586 Q05397\n", + "P17655 Q05397\n", + "P29323 Q05397\n", + "Q05397 Q8WYR1\n", + "Q8WYR1 Q05397\n", + "P55210 Q05397\n", + "Q00535 Q05397\n", + "Q16610 Q05397\n", + "P35968 Q05397\n", + "Q07889 Q05397\n", + "Q05397 P42336\n", + "P15692 Q05397\n", + "P13612 Q05397\n", + "P00533 Q05397\n", + "P31431 Q05397\n", + "P16284 Q05397\n", + "Q03181 Q05397\n", + "P23443 Q05397\n", + "Q05397 Q92569\n", + "Q92569 Q05397\n", + "P20827 Q05397\n", + "P42574 Q05397\n", + "Q05397 O00329\n", + "O00329 Q05397\n", + "P48061 Q05397\n", + "P01375 Q05397\n", + "COMPLEX:Q04206_Q04864 Q05397\n", + "COMPLEX:Q00653_Q01201 Q05397\n", + "P37231 P12830\n", + "P12830 Q15942\n", + "P05412 P12830\n", + "P01106 P12830\n", + "COMPLEX:P19838_Q04206 P12830\n", + "P19544 P12830\n", + "P08581 P12830\n", + "P10275 P12830\n", + "O75030 P12830\n", + "P60953 P12830\n", + "O60716 P12830\n", + "P61224 P12830\n", + "Q13485 P12830\n", + "P12830 P63000\n", + "P63000 P12830\n", + "P12830 P35222\n", + "P12830 P27986\n", + "P12830 P61586\n", + "P12830 P42336\n", + "P12830 P00533\n", + "P12830 P20827\n", + "Q9H3D4 P12830\n", + "COMPLEX:Q04206_Q04864 P12830\n", + "COMPLEX:Q00653_Q01201 P12830\n", + "P37231 P19022\n", + "O15105 P19022\n", + "P00519 P19022\n", + "P05412 P19022\n", + "P01106 P19022\n", + "COMPLEX:P19838_Q04206 P19022\n", + "P19544 P19022\n", + "P08581 P19022\n", + "P10275 P19022\n", + "P26367 P19022\n", + "P19022 P60953\n", + "O60716 P19022\n", + "P28360 P19022\n", + "P48436 P19022\n", + "P08253 P19022\n", + "P18031 P19022\n", + "P40763 P19022\n", + "Q96IZ0 P19022\n", + "P19022 P63000\n", + "P19022 P35222\n", + "P19022 P27986\n", + "P19022 P61586\n", + "Q00535 P19022\n", + "P19022 P42336\n", + "P19022 P14780\n", + "P19022 P16591\n", + "COMPLEX:Q04206_Q04864 P19022\n", + "COMPLEX:Q00653_Q01201 P19022\n", + "Q9NQB0 P08670\n", + "P19838 P08670\n", + "P41235 P08670\n", + "Q9H2X6 P08670\n", + "P42229 P08670\n", + "P05412 P08670\n", + "COMPLEX:P19838_Q04206 P08670\n", + "P40763 P08670\n", + "Q96IZ0 P08670\n", + "Q13464 P08670\n", + "P35222 P08670\n", + "P55210 P08670\n", + "P42574 P08670\n", + "P01137 P08670\n", + "Q9H3D4 P08670\n", + "P31749 P08670\n", + "COMPLEX:Q04206_Q04864 P08670\n", + "COMPLEX:Q00653_Q01201 P08670\n", + "P49137 P08670\n", + "P53350 P08670\n", + "O14896 P08670\n", + "P54762 O95819\n", + "P37231 O95819\n", + "P29323 O95819\n", + "O95819 P01375\n", + "P01375 O95819\n", + "O95819 O14920\n", + "O95819 Q14164\n", + "O95819 Q9Y6K9\n", + "O95819 O15111\n", + "O95819 Q99759\n", + "O95819 P41279\n", + "O95819 Q9Y2U5\n", + "Q14289 Q15942\n", + "P01106 Q14289\n", + "P48736 Q14289\n", + "Q14289 Q9ULH1\n", + "P61224 Q14289\n", + "Q14289 P10599\n", + "Q14289 P53778\n", + "Q14289 P40763\n", + "Q14289 P63000\n", + "P35968 Q14289\n", + "Q14289 Q07889\n", + "P42336 Q14289\n", + "P15692 Q14289\n", + "P13612 Q14289\n", + "Q14289 P00533\n", + "P19838 P02452\n", + "O15105 P02452\n", + "Q13485 P02452\n", + "P02452 P16144\n", + "P63000 P02452\n", + "P02452 P27986\n", + "P02452 P61586\n", + "P61586 P02452\n", + "P17655 P02452\n", + "P02452 P55210\n", + "P02452 Q07889\n", + "P02452 P42336\n", + "P02452 P13612\n", + "P02452 P31431\n", + "P02452 P42574\n", + "P01137 P02452\n", + "P41235 Q9NQB0\n", + "Q9NQB0 P05412\n", + "P05412 Q9NQB0\n", + "Q9NQB0 P01106\n", + "P10275 Q9NQB0\n", + "Q9NQB0 O75030\n", + "P26367 Q9NQB0\n", + "Q13485 Q9NQB0\n", + "Q9NQB0 P40763\n", + "Q9NQB0 P35222\n", + "P35222 Q9NQB0\n", + "Q9NQB0 P55210\n", + "Q9NQB0 P15692\n", + "Q9NQB0 Q03181\n", + "Q9NQB0 P42574\n", + "Q9NQB0 P48061\n", + "P19838 P42229\n", + "P37231 P19838\n", + "P19838 P05412\n", + "P19838 P01106\n", + "COMPLEX:P19838_Q04206 P19838\n", + "P19838 P19544\n", + "P19838 P10275\n", + "P19838 P05231\n", + "P19838 P08253\n", + "P19838 Q12923\n", + "P10599 P19838\n", + "P63000 P19838\n", + "P27986 P19838\n", + "P19838 P35968\n", + "P42336 P19838\n", + "P19838 P15692\n", + "P19838 P00533\n", + "P00533 P19838\n", + "P19838 P14780\n", + "P19838 P01137\n", + 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P27986\n", + "P01137 P27986\n", + "P27986 P31749\n", + "COMPLEX:Q04206_Q04864 P27986\n", + "COMPLEX:Q00653_Q01201 P27986\n", + "P17655 P61586\n", + "P61586 Q07889\n", + "P61586 P42336\n", + "P42336 P61586\n", + "P61586 P13612\n", + "P00533 P61586\n", + "P61586 P14780\n", + "P20827 P61586\n", + "P42574 P61586\n", + "P01375 P61586\n", + "P61586 P31749\n", + "P29323 P42336\n", + "P48061 P29323\n", + "P29323 P01137\n", + "P01137 P29323\n", + "COMPLEX:Q04206_Q04864 P29323\n", + "COMPLEX:Q00653_Q01201 P29323\n", + "P35968 Q8WYR1\n", + "P00533 Q8WYR1\n", + "P48061 Q8WYR1\n", + "Q8WYR1 P31749\n", + "P42574 P55210\n", + "COMPLEX:Q04206_Q04864 P55210\n", + "COMPLEX:Q00653_Q01201 P55210\n", + "P01137 Q16610\n", + "P35968 Q07889\n", + "P35968 P42336\n", + "P15692 P35968\n", + "P35968 P16284\n", + "P35968 Q92569\n", + "P35968 O00329\n", + "P35968 P31749\n", + "COMPLEX:Q04206_Q04864 P35968\n", + "COMPLEX:Q00653_Q01201 P35968\n", + "Q07889 P42336\n", + "P42336 Q07889\n", + "P15692 Q07889\n", + "P00533 Q07889\n", + "Q92569 Q07889\n", + "O00329 Q07889\n", + "Q07889 P31749\n", + "P15692 P42336\n", + "P00533 P42336\n", + "P42336 P23443\n", + "Q92569 P42336\n", + "P48061 P42336\n", + "P01137 P42336\n", + "P42336 P31749\n", + "COMPLEX:Q04206_Q04864 P42336\n", + "COMPLEX:Q00653_Q01201 P42336\n", + "P15692 P00533\n", + "P15692 P14780\n", + "P01137 P15692\n", + "Q9H3D4 P15692\n", + "COMPLEX:Q04206_Q04864 P15692\n", + "COMPLEX:Q00653_Q01201 P15692\n", + "P49137 P15692\n", + "P00533 P14780\n", + "P00533 Q92569\n", + "P00533 O00329\n", + "P01137 P00533\n", + "COMPLEX:Q04206_Q04864 P00533\n", + "COMPLEX:Q00653_Q01201 P00533\n", + "P14780 P31431\n", + "COMPLEX:Q04206_Q04864 P31431\n", + "COMPLEX:Q00653_Q01201 P31431\n", + "Q03181 P14780\n", + "P23443 P14780\n", + "P48061 P14780\n", + "P14780 P01137\n", + "P01375 P14780\n", + "COMPLEX:Q04206_Q04864 P14780\n", + "COMPLEX:Q00653_Q01201 P14780\n", + "P16591 P16284\n", + "COMPLEX:Q04206_Q04864 P16284\n", + "COMPLEX:Q00653_Q01201 P16284\n", + "Q03181 P01137\n", + "P23443 P01137\n", + "P01137 P23443\n", + "P01375 P23443\n", + "P23443 Q9H3D4\n", + "P31749 P23443\n", + "P48061 Q92569\n", + "Q92569 P31749\n", + "P01375 P42574\n", + "P42574 O14920\n", + "P42574 Q9H3D4\n", + "P42574 P31749\n", + "P48061 O00329\n", + "O00329 P31749\n", + "P01137 P48061\n", + "COMPLEX:Q04206_Q04864 P48061\n", + "COMPLEX:Q00653_Q01201 P48061\n", + "P01375 P01137\n", + "P01137 P31749\n", + "P31749 P01137\n", + "COMPLEX:Q04206_Q04864 P01137\n", + "COMPLEX:Q00653_Q01201 P01137\n", + "O14896 P01137\n", + "P01375 O14920\n", + "P01375 Q9Y6K9\n", + "P01375 O15111\n", + "Q9H3D4 P01375\n", + "P01375 P31749\n", + "COMPLEX:Q04206_Q04864 P01375\n", + "COMPLEX:Q00653_Q01201 P01375\n", + "P01375 P49137\n", + "P53350 P01375\n", + "P01375 O14896\n", + "O14896 P01375\n", + "Q9Y6K9 O14920\n", + "O15111 O14920\n", + "O14920 Q9H3D4\n", + "P31749 O14920\n", + "Q99759 O14920\n", + "P53350 O14920\n", + "Q9Y2U5 O14920\n", + "Q14164 COMPLEX:Q04206_Q04864\n", + "COMPLEX:Q04206_Q04864 Q14164\n", + "COMPLEX:Q00653_Q01201 Q14164\n", + "Q9Y6K9 O15111\n", + "P31749 Q9Y6K9\n", + "Q99759 Q9Y6K9\n", + "P41279 Q9Y6K9\n", + "Q9Y2U5 Q9Y6K9\n", + "Q9H3D4 O15111\n", + "P31749 O15111\n", + "O15111 COMPLEX:Q00653_Q01201\n", + "Q99759 O15111\n", + "P41279 O15111\n", + "Q9Y2U5 O15111\n", + "Q9H3D4 P31749\n", + "COMPLEX:Q04206_Q04864 Q9H3D4\n", + "COMPLEX:Q00653_Q01201 Q9H3D4\n", + "P53350 Q9H3D4\n", + "COMPLEX:Q04206_Q04864 P31749\n", + "COMPLEX:Q00653_Q01201 P31749\n", + "P31749 P41279\n", + "COMPLEX:Q04206_Q04864 P53350\n", + "COMPLEX:Q04206_Q04864 P41279\n", + "COMPLEX:Q00653_Q01201 P53350\n", + "COMPLEX:Q00653_Q01201 P41279\n", + "P49137 P53350\n", + "P41279 P53350\n", + "looking for paths in the network with length: 0 for node VIM and PTK2B\n", + "looking for paths in the network with length: 1 for node VIM and PTK2B\n", + "looking for paths in the network with length: 2 for node VIM and PTK2B\n", + "Found a path!\n", + "[['VIM', 'STAT3', 'PTK2B']]\n", + "looking for paths in the network with length: 0 for node VIM and COL1A1\n", + "looking for paths in the network with length: 1 for node VIM and COL1A1\n", + "looking for paths in the network with length: 2 for node VIM and COL1A1\n", + "Found a path!\n", + "[['VIM', 'CASP3', 'COL1A1'], ['VIM', 'CASP7', 'COL1A1']]\n", + "looking for paths in the network with length: 0 for node MAP4K4 and PTK2B\n", + "looking for paths in the network with length: 1 for node MAP4K4 and PTK2B\n", + "looking for paths in the network with length: 2 for node MAP4K4 and PTK2B\n", + "looking for paths in the network with length: 3 for node MAP4K4 and PTK2B\n", + "Found a path!\n", + "[['MAP4K4', 'CHUK', 'MYC', 'PTK2B'], ['MAP4K4', 'TNF', 'PIK3CG', 'PTK2B'], ['MAP4K4', 'TNF', 'TXN', 'PTK2B']]\n", + "looking for paths in the network with length: 0 for node MAP4K4 and COL1A1\n", + "looking for paths in the network with length: 1 for node MAP4K4 and COL1A1\n", + "looking for paths in the network with length: 2 for node MAP4K4 and COL1A1\n", + "looking for paths in the network with length: 3 for node MAP4K4 and COL1A1\n", + "Found a path!\n", + "[['MAP4K4', 'IKBKB', 'NFKB1', 'COL1A1'], ['MAP4K4', 'IKBKG', 'NFKB1', 'COL1A1'], ['MAP4K4', 'MAP3K3', 'NFKB1', 'COL1A1'], ['MAP4K4', 'MAP3K2', 'NFKB1', 'COL1A1'], ['MAP4K4', 'CHUK', 'NFKB1', 'COL1A1'], ['MAP4K4', 'TNF', 'TGFB1', 'COL1A1'], ['MAP4K4', 'TNF', 'NFKB1', 'COL1A1'], ['MAP4K4', 'TNF', 'RHOA', 'COL1A1'], ['MAP4K4', 'IKBKE', 'NFKB1', 'COL1A1'], ['MAP4K4', 'EPHB1', 'SRC', 'COL1A1'], ['MAP4K4', 'PPARG', 'SRC', 'COL1A1']]\n", + "looking for paths in the network with length: 0 for node PTK2B and COL1A1\n", + "looking for paths in the network with length: 1 for node PTK2B and COL1A1\n", + "looking for paths in the network with length: 2 for node PTK2B and COL1A1\n", + "Found a path!\n", + "[['PTK2B', 'RAC1', 'COL1A1'], ['PTK2B', 'SRC', 'COL1A1'], ['PTK2B', 'PIK3CA', 'COL1A1'], ['PTK2B', 'ITGA4', 'COL1A1']]\n", + "CPU times: user 15min 18s, sys: 436 ms, total: 15min 18s\n", + "Wall time: 15min 18s\n" + ] + }, + { + "name": "stdout", + "output_type": "stream", + "text": [ + "P54762 Q05397\n", + "COMPLEX:P05412_P53539 P12830\n", + "COMPLEX:P19838_Q04206 P12830\n", + "COMPLEX:P17535_P53539 P12830\n", + "COMPLEX:Q01201 P12830\n", + "COMPLEX:P15408_P17275 P12830\n", + "COMPLEX:P15407_P17535 P12830\n", + "COMPLEX:P01100_P17275 P12830\n", + "COMPLEX:P19838_Q04864 P12830\n", + "COMPLEX:Q04206 P12830\n", + "COMPLEX:P19838_Q01201 P12830\n", + "COMPLEX:P15407_P17275 P12830\n", + "COMPLEX:P05412_P17275 P12830\n", + "COMPLEX:P17535 P12830\n", + "COMPLEX:Q00653_Q01201 P12830\n", + "COMPLEX:P17275_P53539 P12830\n", + "COMPLEX:P19838_Q00653 P12830\n", + "COMPLEX:P15408_P17535 P12830\n", + "COMPLEX:Q00653_Q04206 P12830\n", + "COMPLEX:P19838 P12830\n", + "COMPLEX:Q04864 P12830\n", + "COMPLEX:P05412_P17535 P12830\n", + "COMPLEX:P01100_P05412 P12830\n", + "COMPLEX:P17275 P12830\n", + "COMPLEX:P05412_P15407 P12830\n", + "COMPLEX:P05412 P12830\n", + 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Q14289\n", + "COMPLEX:P15407_P17275 Q14289\n", + "COMPLEX:P05412_P17275 Q14289\n", + "COMPLEX:P17535 Q14289\n", + "COMPLEX:P17275_P53539 Q14289\n", + "COMPLEX:P15408_P17535 Q14289\n", + "COMPLEX:P05412_P17535 Q14289\n", + "COMPLEX:P01100_P05412 Q14289\n", + "COMPLEX:P17275 Q14289\n", + "COMPLEX:P05412_P15407 Q14289\n", + "COMPLEX:P05412 Q14289\n", + "COMPLEX:P01100_P17535 Q14289\n", + "COMPLEX:P05412_P15408 Q14289\n", + "COMPLEX:P17275_P17535 Q14289\n", + "P19838 P02452\n", + "P08047 P02452\n", + "Q02447 P02452\n", + "COMPLEX:P05412_P53539 P19838\n", + "COMPLEX:P05412_P53539 P08047\n", + "COMPLEX:P05412_P53539 Q02447\n", + "COMPLEX:P05412_P53539 P37231\n", + "COMPLEX:P19838_Q04206 P19838\n", + "COMPLEX:P19838_Q04206 P08047\n", + "COMPLEX:P19838_Q04206 Q02447\n", + "COMPLEX:P19838_Q04206 P42229\n", + "COMPLEX:P19838_Q04206 P41235\n", + "COMPLEX:P19838_Q04206 P37231\n", + "COMPLEX:P17535_P53539 P19838\n", + "COMPLEX:P17535_P53539 P08047\n", + "COMPLEX:P17535_P53539 Q02447\n", + 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"COMPLEX:Q01201_Q04206 P19838\n", + "COMPLEX:P05412_P15408 P19838\n", + "COMPLEX:P17275_P17535 P19838\n", + "Q9Y2U5 P19838\n", + "P37231 P19838\n", + "P41235 Q9NQB0\n", + "COMPLEX:Q01201 P08047\n", + "COMPLEX:Q01201 Q02447\n", + "COMPLEX:Q01201 P42229\n", + "COMPLEX:Q01201 P41235\n", + "COMPLEX:Q01201 P37231\n", + "COMPLEX:P15408_P17275 P08047\n", + "COMPLEX:P15408_P17275 Q02447\n", + "COMPLEX:P15408_P17275 P37231\n", + "COMPLEX:P15407_P17535 P08047\n", + "COMPLEX:P15407_P17535 Q02447\n", + "COMPLEX:P15407_P17535 P37231\n", + "COMPLEX:P01100_P17275 P08047\n", + "COMPLEX:P19838_Q04864 P08047\n", + "COMPLEX:Q04206 P08047\n", + "COMPLEX:P19838_Q01201 P08047\n", + "COMPLEX:P15407_P17275 P08047\n", + "COMPLEX:P05412_P17275 P08047\n", + "COMPLEX:P17535 P08047\n", + "Q02447 P08047\n", + "COMPLEX:Q00653_Q01201 P08047\n", + "COMPLEX:P17275_P53539 P08047\n", + "COMPLEX:P19838_Q00653 P08047\n", + "COMPLEX:P15408_P17535 P08047\n", + "COMPLEX:Q00653_Q04206 P08047\n", + "COMPLEX:P19838 P08047\n", + "COMPLEX:Q04864 P08047\n", + "COMPLEX:P05412_P17535 P08047\n", + "P08047 P41235\n", + "COMPLEX:P01100_P05412 P08047\n", + "COMPLEX:P17275 P08047\n", + "COMPLEX:P05412_P15407 P08047\n", + "COMPLEX:P05412 P08047\n", + "COMPLEX:P01100_P17535 P08047\n", + "COMPLEX:Q04206_Q04864 P08047\n", + "COMPLEX:Q01201_Q04864 P08047\n", + "COMPLEX:Q00653 P08047\n", + "COMPLEX:Q00653_Q04864 P08047\n", + "COMPLEX:Q01201_Q04206 P08047\n", + "COMPLEX:P05412_P15408 P08047\n", + "COMPLEX:P17275_P17535 P08047\n", + "P08047 P54762\n", + "P37231 P08047\n", + "COMPLEX:P01100_P17275 Q02447\n", + "COMPLEX:P01100_P17275 P37231\n", + "COMPLEX:P19838_Q04864 Q02447\n", + "COMPLEX:P19838_Q04864 P42229\n", + "COMPLEX:P19838_Q04864 P41235\n", + "COMPLEX:P19838_Q04864 P37231\n", + "COMPLEX:Q04206 Q02447\n", + "COMPLEX:Q04206 P42229\n", + "COMPLEX:Q04206 P41235\n", + "COMPLEX:Q04206 P37231\n", + "COMPLEX:P19838_Q01201 Q02447\n", + "COMPLEX:P19838_Q01201 P42229\n", + "COMPLEX:P19838_Q01201 P41235\n", + "COMPLEX:P19838_Q01201 P37231\n", + "COMPLEX:P15407_P17275 Q02447\n", + "COMPLEX:P15407_P17275 P37231\n", + "COMPLEX:P05412_P17275 Q02447\n", + "COMPLEX:P05412_P17275 P37231\n", + "COMPLEX:P17535 Q02447\n", + "COMPLEX:P17535 P37231\n", + "COMPLEX:Q00653_Q01201 Q02447\n", + "COMPLEX:P17275_P53539 Q02447\n", + "COMPLEX:P19838_Q00653 Q02447\n", + "COMPLEX:P15408_P17535 Q02447\n", + "COMPLEX:Q00653_Q04206 Q02447\n", + "COMPLEX:P19838 Q02447\n", + "COMPLEX:Q04864 Q02447\n", + "COMPLEX:P05412_P17535 Q02447\n", + "COMPLEX:P01100_P05412 Q02447\n", + "COMPLEX:P17275 Q02447\n", + "COMPLEX:P05412_P15407 Q02447\n", + "COMPLEX:P05412 Q02447\n", + "COMPLEX:P01100_P17535 Q02447\n", + "COMPLEX:Q04206_Q04864 Q02447\n", + "COMPLEX:Q01201_Q04864 Q02447\n", + "COMPLEX:Q00653 Q02447\n", + "COMPLEX:Q00653_Q04864 Q02447\n", + "COMPLEX:Q01201_Q04206 Q02447\n", + "COMPLEX:P05412_P15408 Q02447\n", + "COMPLEX:P17275_P17535 Q02447\n", + "COMPLEX:Q00653_Q01201 P42229\n", + "COMPLEX:P19838_Q00653 P42229\n", + "COMPLEX:Q00653_Q04206 P42229\n", + "COMPLEX:P19838 P42229\n", + "COMPLEX:Q04864 P42229\n", + "COMPLEX:Q04206_Q04864 P42229\n", + "COMPLEX:Q01201_Q04864 P42229\n", + "COMPLEX:Q00653 P42229\n", + "COMPLEX:Q00653_Q04864 P42229\n", + "COMPLEX:Q01201_Q04206 P42229\n", + "P37231 P42229\n", + "COMPLEX:Q00653_Q01201 P41235\n", + "COMPLEX:Q00653_Q01201 P37231\n", + "COMPLEX:P17275_P53539 P37231\n", + "COMPLEX:P19838_Q00653 P41235\n", + "COMPLEX:P19838_Q00653 P37231\n", + "COMPLEX:P15408_P17535 P37231\n", + "COMPLEX:Q00653_Q04206 P41235\n", + "COMPLEX:Q00653_Q04206 P37231\n", + "COMPLEX:P19838 P41235\n", + "COMPLEX:P19838 P37231\n", + "COMPLEX:Q04864 P41235\n", + "COMPLEX:Q04864 P37231\n", + "COMPLEX:P05412_P17535 P37231\n", + "COMPLEX:Q04206_Q04864 P41235\n", + "COMPLEX:Q01201_Q04864 P41235\n", + "COMPLEX:Q00653 P41235\n", + "COMPLEX:Q00653_Q04864 P41235\n", + "COMPLEX:Q01201_Q04206 P41235\n", + "COMPLEX:P01100_P05412 P37231\n", + "COMPLEX:P17275 P37231\n", + "COMPLEX:P05412_P15407 P37231\n", + "COMPLEX:P05412 P37231\n", + "COMPLEX:P01100_P17535 P37231\n", + "COMPLEX:Q04206_Q04864 P37231\n", + "COMPLEX:Q01201_Q04864 P37231\n", + "COMPLEX:Q00653 P37231\n", + "COMPLEX:Q00653_Q04864 P37231\n", + "COMPLEX:Q01201_Q04206 P37231\n", + "COMPLEX:P05412_P15408 P37231\n", + "COMPLEX:P17275_P17535 P37231\n", + "looking for paths in the network with length: 0 for node SRC and PTK2B\n", + "looking for paths in the network with length: 1 for node SRC and PTK2B\n", + "Found a path!\n", + "[['SRC', 'PTK2B']]\n", + "looking for paths in the network with length: 0 for node SRC and COL1A1\n", + "looking for paths in the network with length: 1 for node SRC and COL1A1\n", + "Found a path!\n", + "[['SRC', 'COL1A1']]\n", + "looking for paths in the network with length: 0 for node NOTCH1 and PTK2\n", + "looking for paths in the network with length: 1 for node NOTCH1 and PTK2\n", + "looking for paths in the network with length: 2 for node NOTCH1 and PTK2\n", + "Found a path!\n", + "[['NOTCH1', 'RELB', 'PTK2'], ['NOTCH1', 'COMPLEX:P19838_Q04864', 'PTK2'], ['NOTCH1', 'COMPLEX:Q00653_Q01201', 'PTK2'], ['NOTCH1', 'RELA', 'PTK2'], ['NOTCH1', 'NFKB1', 'PTK2'], ['NOTCH1', 'COMPLEX:Q00653_Q04206', 'PTK2'], ['NOTCH1', 'COMPLEX:P19838_Q04206', 'PTK2'], ['NOTCH1', 'COMPLEX:P19838_Q01201', 'PTK2'], ['NOTCH1', 'COMPLEX:Q04206_Q04864', 'PTK2'], ['NOTCH1', 'COMPLEX:P19838_Q00653', 'PTK2'], ['NOTCH1', 'REL', 'PTK2'], ['NOTCH1', 'COMPLEX:Q01201_Q04206', 'PTK2'], ['NOTCH1', 'COMPLEX:Q01201_Q04864', 'PTK2'], ['NOTCH1', 'NFKB2', 'PTK2'], ['NOTCH1', 'COMPLEX:Q00653_Q04864', 'PTK2']]\n", + "looking for paths in the network with length: 0 for node NOTCH1 and CDH1\n", + "looking for paths in the network with length: 1 for node NOTCH1 and CDH1\n", + "looking for paths in the network with length: 2 for node NOTCH1 and CDH1\n", + "Found a path!\n", + "[['NOTCH1', 'RELB', 'CDH1'], ['NOTCH1', 'COMPLEX:P19838_Q04864', 'CDH1'], ['NOTCH1', 'COMPLEX:Q00653_Q01201', 'CDH1'], ['NOTCH1', 'RELA', 'CDH1'], ['NOTCH1', 'PPARG', 'CDH1'], ['NOTCH1', 'NFKB1', 'CDH1'], ['NOTCH1', 'COMPLEX:Q00653_Q04206', 'CDH1'], ['NOTCH1', 'COMPLEX:P19838_Q04206', 'CDH1'], ['NOTCH1', 'COMPLEX:P19838_Q01201', 'CDH1'], ['NOTCH1', 'COMPLEX:Q04206_Q04864', 'CDH1'], ['NOTCH1', 'COMPLEX:P19838_Q00653', 'CDH1'], ['NOTCH1', 'REL', 'CDH1'], ['NOTCH1', 'COMPLEX:Q01201_Q04206', 'CDH1'], ['NOTCH1', 'COMPLEX:Q01201_Q04864', 'CDH1'], ['NOTCH1', 'NFKB2', 'CDH1'], ['NOTCH1', 'COMPLEX:Q00653_Q04864', 'CDH1']]\n", + "looking for paths in the network with length: 0 for node NOTCH1 and CDH2\n", + "looking for paths in the network with length: 1 for node NOTCH1 and CDH2\n", + "Found a path!\n", + "[['NOTCH1', 'CDH2']]\n", + "looking for paths in the network with length: 0 for node NOTCH1 and VIM\n", + "looking for paths in the network with length: 1 for node NOTCH1 and VIM\n", + "looking for paths in the network with length: 2 for node NOTCH1 and VIM\n", + "Found a path!\n", + "[['NOTCH1', 'RELB', 'VIM'], ['NOTCH1', 'SP3', 'VIM'], ['NOTCH1', 'COMPLEX:P19838_Q04864', 'VIM'], ['NOTCH1', 'COMPLEX:Q00653_Q01201', 'VIM'], ['NOTCH1', 'RELA', 'VIM'], ['NOTCH1', 'NFKB1', 'VIM'], ['NOTCH1', 'SP1', 'VIM'], ['NOTCH1', 'COMPLEX:Q00653_Q04206', 'VIM'], ['NOTCH1', 'COMPLEX:P19838_Q04206', 'VIM'], ['NOTCH1', 'COMPLEX:P19838_Q01201', 'VIM'], ['NOTCH1', 'COMPLEX:Q04206_Q04864', 'VIM'], ['NOTCH1', 'COMPLEX:P19838_Q00653', 'VIM'], ['NOTCH1', 'REL', 'VIM'], ['NOTCH1', 'NFKB1', 'VIM'], ['NOTCH1', 'COMPLEX:Q01201_Q04206', 'VIM'], ['NOTCH1', 'COMPLEX:Q01201_Q04864', 'VIM'], ['NOTCH1', 'NFKB2', 'VIM'], ['NOTCH1', 'COMPLEX:Q00653_Q04864', 'VIM']]\n", + "looking for paths in the network with length: 0 for node NOTCH1 and MAP4K4\n", + "looking for paths in the network with length: 1 for node NOTCH1 and MAP4K4\n", + "looking for paths in the network with length: 2 for node NOTCH1 and MAP4K4\n", + "Found a path!\n", + "[['NOTCH1', 'PPARG', 'MAP4K4']]\n", + "looking for paths in the network with length: 0 for node NOTCH1 and PTK2B\n", + "looking for paths in the network with length: 1 for node NOTCH1 and PTK2B\n", + "looking for paths in the network with length: 2 for node NOTCH1 and PTK2B\n", + "looking for paths in the network with length: 3 for node NOTCH1 and PTK2B\n" + ] + }, + { + "name": "stdout", + "output_type": "stream", + "text": [ + "Found a path!\n", + "[['NOTCH1', 'RELB', 'SRC', 'PTK2B'], ['NOTCH1', 'RELB', 'PTK2', 'PTK2B'], ['NOTCH1', 'SP3', 'COMPLEX:P15407_P17275', 'PTK2B'], ['NOTCH1', 'SP3', 'COMPLEX:P05412_P53539', 'PTK2B'], ['NOTCH1', 'SP3', 'COMPLEX:P05412_P17535', 'PTK2B'], ['NOTCH1', 'SP3', 'COMPLEX:P17275_P53539', 'PTK2B'], ['NOTCH1', 'SP3', 'COMPLEX:P05412_P15407', 'PTK2B'], ['NOTCH1', 'SP3', 'COMPLEX:P05412_P17275', 'PTK2B'], ['NOTCH1', 'SP3', 'COMPLEX:P01100_P17275', 'PTK2B'], ['NOTCH1', 'SP3', 'JUND', 'PTK2B'], ['NOTCH1', 'SP3', 'COMPLEX:P05412_P15408', 'PTK2B'], ['NOTCH1', 'SP3', 'COMPLEX:P01100_P05412', 'PTK2B'], ['NOTCH1', 'SP3', 'COMPLEX:P17535_P53539', 'PTK2B'], ['NOTCH1', 'SP3', 'SRC', 'PTK2B'], ['NOTCH1', 'SP3', 'COMPLEX:P15408_P17535', 'PTK2B'], ['NOTCH1', 'SP3', 'JUN', 'PTK2B'], ['NOTCH1', 'SP3', 'JUNB', 'PTK2B'], ['NOTCH1', 'SP3', 'COMPLEX:P15408_P17275', 'PTK2B'], ['NOTCH1', 'SP3', 'COMPLEX:P01100_P17535', 'PTK2B'], ['NOTCH1', 'SP3', 'COMPLEX:P15407_P17535', 'PTK2B'], ['NOTCH1', 'SP3', 'COMPLEX:P17275_P17535', 'PTK2B'], ['NOTCH1', 'COL1A1', 'SRC', 'PTK2B'], ['NOTCH1', 'COMPLEX:P19838_Q04864', 'SRC', 'PTK2B'], ['NOTCH1', 'COMPLEX:P19838_Q04864', 'PTK2', 'PTK2B'], ['NOTCH1', 'COMPLEX:Q00653_Q01201', 'SRC', 'PTK2B'], ['NOTCH1', 'COMPLEX:Q00653_Q01201', 'PTK2', 'PTK2B'], ['NOTCH1', 'CDH2', 'COMPLEX:P15407_P17275', 'PTK2B'], ['NOTCH1', 'CDH2', 'COMPLEX:P05412_P53539', 'PTK2B'], ['NOTCH1', 'CDH2', 'COMPLEX:P05412_P17535', 'PTK2B'], ['NOTCH1', 'CDH2', 'COMPLEX:P17275_P53539', 'PTK2B'], ['NOTCH1', 'CDH2', 'COMPLEX:P05412_P15407', 'PTK2B'], ['NOTCH1', 'CDH2', 'COMPLEX:P05412_P17275', 'PTK2B'], ['NOTCH1', 'CDH2', 'COMPLEX:P01100_P17275', 'PTK2B'], ['NOTCH1', 'CDH2', 'JUND', 'PTK2B'], ['NOTCH1', 'CDH2', 'COMPLEX:P05412_P15408', 'PTK2B'], ['NOTCH1', 'CDH2', 'COMPLEX:P01100_P05412', 'PTK2B'], ['NOTCH1', 'CDH2', 'COMPLEX:P17535_P53539', 'PTK2B'], ['NOTCH1', 'CDH2', 'SRC', 'PTK2B'], ['NOTCH1', 'CDH2', 'COMPLEX:P15408_P17535', 'PTK2B'], ['NOTCH1', 'CDH2', 'JUN', 'PTK2B'], ['NOTCH1', 'CDH2', 'JUNB', 'PTK2B'], ['NOTCH1', 'CDH2', 'COMPLEX:P15408_P17275', 'PTK2B'], ['NOTCH1', 'CDH2', 'COMPLEX:P01100_P17535', 'PTK2B'], ['NOTCH1', 'CDH2', 'COMPLEX:P15407_P17535', 'PTK2B'], ['NOTCH1', 'CDH2', 'COMPLEX:P17275_P17535', 'PTK2B'], ['NOTCH1', 'RELA', 'SRC', 'PTK2B'], ['NOTCH1', 'RELA', 'PTK2', 'PTK2B'], ['NOTCH1', 'PPARG', 'COMPLEX:P15407_P17275', 'PTK2B'], ['NOTCH1', 'PPARG', 'COMPLEX:P05412_P53539', 'PTK2B'], ['NOTCH1', 'PPARG', 'COMPLEX:P05412_P17535', 'PTK2B'], ['NOTCH1', 'PPARG', 'COMPLEX:P17275_P53539', 'PTK2B'], ['NOTCH1', 'PPARG', 'COMPLEX:P05412_P15407', 'PTK2B'], ['NOTCH1', 'PPARG', 'COMPLEX:P05412_P17275', 'PTK2B'], ['NOTCH1', 'PPARG', 'COMPLEX:P01100_P17275', 'PTK2B'], ['NOTCH1', 'PPARG', 'JUND', 'PTK2B'], ['NOTCH1', 'PPARG', 'COMPLEX:P05412_P15408', 'PTK2B'], ['NOTCH1', 'PPARG', 'COMPLEX:P01100_P05412', 'PTK2B'], ['NOTCH1', 'PPARG', 'COMPLEX:P17535_P53539', 'PTK2B'], ['NOTCH1', 'PPARG', 'SRC', 'PTK2B'], ['NOTCH1', 'PPARG', 'COMPLEX:P15408_P17535', 'PTK2B'], ['NOTCH1', 'PPARG', 'JUN', 'PTK2B'], ['NOTCH1', 'PPARG', 'JUNB', 'PTK2B'], ['NOTCH1', 'PPARG', 'COMPLEX:P15408_P17275', 'PTK2B'], ['NOTCH1', 'PPARG', 'COMPLEX:P01100_P17535', 'PTK2B'], ['NOTCH1', 'PPARG', 'COMPLEX:P15407_P17535', 'PTK2B'], ['NOTCH1', 'PPARG', 'COMPLEX:P17275_P17535', 'PTK2B'], ['NOTCH1', 'NFKB1', 'SRC', 'PTK2B'], ['NOTCH1', 'NFKB1', 'PTK2', 'PTK2B'], ['NOTCH1', 'SP1', 'COMPLEX:P15407_P17275', 'PTK2B'], ['NOTCH1', 'SP1', 'COMPLEX:P05412_P53539', 'PTK2B'], ['NOTCH1', 'SP1', 'COMPLEX:P05412_P17535', 'PTK2B'], ['NOTCH1', 'SP1', 'COMPLEX:P17275_P53539', 'PTK2B'], ['NOTCH1', 'SP1', 'COMPLEX:P05412_P15407', 'PTK2B'], ['NOTCH1', 'SP1', 'COMPLEX:P05412_P17275', 'PTK2B'], ['NOTCH1', 'SP1', 'COMPLEX:P01100_P17275', 'PTK2B'], ['NOTCH1', 'SP1', 'JUND', 'PTK2B'], ['NOTCH1', 'SP1', 'COMPLEX:P05412_P15408', 'PTK2B'], ['NOTCH1', 'SP1', 'COMPLEX:P01100_P05412', 'PTK2B'], ['NOTCH1', 'SP1', 'COMPLEX:P17535_P53539', 'PTK2B'], ['NOTCH1', 'SP1', 'SRC', 'PTK2B'], ['NOTCH1', 'SP1', 'COMPLEX:P15408_P17535', 'PTK2B'], ['NOTCH1', 'SP1', 'JUN', 'PTK2B'], ['NOTCH1', 'SP1', 'JUNB', 'PTK2B'], ['NOTCH1', 'SP1', 'COMPLEX:P15408_P17275', 'PTK2B'], ['NOTCH1', 'SP1', 'COMPLEX:P01100_P17535', 'PTK2B'], ['NOTCH1', 'SP1', 'COMPLEX:P15407_P17535', 'PTK2B'], ['NOTCH1', 'SP1', 'COMPLEX:P17275_P17535', 'PTK2B'], ['NOTCH1', 'COMPLEX:Q00653_Q04206', 'SRC', 'PTK2B'], ['NOTCH1', 'COMPLEX:Q00653_Q04206', 'PTK2', 'PTK2B'], ['NOTCH1', 'COMPLEX:P19838_Q04206', 'SRC', 'PTK2B'], ['NOTCH1', 'COMPLEX:P19838_Q04206', 'PTK2', 'PTK2B'], ['NOTCH1', 'COMPLEX:P19838_Q01201', 'SRC', 'PTK2B'], ['NOTCH1', 'COMPLEX:P19838_Q01201', 'PTK2', 'PTK2B'], ['NOTCH1', 'COMPLEX:Q04206_Q04864', 'SRC', 'PTK2B'], ['NOTCH1', 'COMPLEX:Q04206_Q04864', 'PTK2', 'PTK2B'], ['NOTCH1', 'COMPLEX:P19838_Q00653', 'SRC', 'PTK2B'], ['NOTCH1', 'COMPLEX:P19838_Q00653', 'PTK2', 'PTK2B'], ['NOTCH1', 'REL', 'SRC', 'PTK2B'], ['NOTCH1', 'REL', 'PTK2', 'PTK2B'], ['NOTCH1', 'NFKB1', 'COMPLEX:P15407_P17275', 'PTK2B'], ['NOTCH1', 'NFKB1', 'COMPLEX:P05412_P53539', 'PTK2B'], ['NOTCH1', 'NFKB1', 'COMPLEX:P05412_P17535', 'PTK2B'], ['NOTCH1', 'NFKB1', 'COMPLEX:P17275_P53539', 'PTK2B'], ['NOTCH1', 'NFKB1', 'COMPLEX:P05412_P15407', 'PTK2B'], ['NOTCH1', 'NFKB1', 'COMPLEX:P05412_P17275', 'PTK2B'], ['NOTCH1', 'NFKB1', 'COMPLEX:P01100_P17275', 'PTK2B'], ['NOTCH1', 'NFKB1', 'JUND', 'PTK2B'], ['NOTCH1', 'NFKB1', 'COMPLEX:P05412_P15408', 'PTK2B'], ['NOTCH1', 'NFKB1', 'COMPLEX:P01100_P05412', 'PTK2B'], ['NOTCH1', 'NFKB1', 'COMPLEX:P17535_P53539', 'PTK2B'], ['NOTCH1', 'NFKB1', 'SRC', 'PTK2B'], ['NOTCH1', 'NFKB1', 'COMPLEX:P15408_P17535', 'PTK2B'], ['NOTCH1', 'NFKB1', 'JUN', 'PTK2B'], ['NOTCH1', 'NFKB1', 'JUNB', 'PTK2B'], ['NOTCH1', 'NFKB1', 'COMPLEX:P15408_P17275', 'PTK2B'], ['NOTCH1', 'NFKB1', 'COMPLEX:P01100_P17535', 'PTK2B'], ['NOTCH1', 'NFKB1', 'COMPLEX:P15407_P17535', 'PTK2B'], ['NOTCH1', 'NFKB1', 'COMPLEX:P17275_P17535', 'PTK2B'], ['NOTCH1', 'COMPLEX:Q01201_Q04206', 'SRC', 'PTK2B'], ['NOTCH1', 'COMPLEX:Q01201_Q04206', 'PTK2', 'PTK2B'], ['NOTCH1', 'COMPLEX:Q01201_Q04864', 'SRC', 'PTK2B'], ['NOTCH1', 'COMPLEX:Q01201_Q04864', 'PTK2', 'PTK2B'], ['NOTCH1', 'NFKB2', 'SRC', 'PTK2B'], ['NOTCH1', 'NFKB2', 'PTK2', 'PTK2B'], ['NOTCH1', 'COMPLEX:Q00653_Q04864', 'SRC', 'PTK2B'], ['NOTCH1', 'COMPLEX:Q00653_Q04864', 'PTK2', 'PTK2B']]\n", + "looking for paths in the network with length: 0 for node NOTCH1 and COL1A1\n", + "looking for paths in the network with length: 1 for node NOTCH1 and COL1A1\n", + "Found a path!\n", + "[['NOTCH1', 'COL1A1']]\n", + "looking for paths in the network with length: 0 for node PTK2 and CDH1\n", + "looking for paths in the network with length: 1 for node PTK2 and CDH1\n", + "looking for paths in the network with length: 2 for node PTK2 and CDH1\n", + "Found a path!\n", + "[['PTK2', 'RELB', 'CDH1'], ['PTK2', 'COMPLEX:P19838_Q04864', 'CDH1'], ['PTK2', 'COMPLEX:Q00653_Q01201', 'CDH1'], ['PTK2', 'SRC', 'CDH1'], ['PTK2', 'RELA', 'CDH1'], ['PTK2', 'NFKB1', 'CDH1'], ['PTK2', 'COMPLEX:Q00653_Q04206', 'CDH1'], ['PTK2', 'COMPLEX:P19838_Q04206', 'CDH1'], ['PTK2', 'COMPLEX:P19838_Q01201', 'CDH1'], ['PTK2', 'COMPLEX:Q04206_Q04864', 'CDH1'], ['PTK2', 'COMPLEX:P19838_Q00653', 'CDH1'], ['PTK2', 'REL', 'CDH1'], ['PTK2', 'COMPLEX:Q01201_Q04206', 'CDH1'], ['PTK2', 'COMPLEX:Q01201_Q04864', 'CDH1'], ['PTK2', 'NFKB2', 'CDH1'], ['PTK2', 'COMPLEX:Q00653_Q04864', 'CDH1']]\n", + "looking for paths in the network with length: 0 for node PTK2 and CDH2\n", + "looking for paths in the network with length: 1 for node PTK2 and CDH2\n", + "looking for paths in the network with length: 2 for node PTK2 and CDH2\n", + "Found a path!\n", + "[['PTK2', 'RELB', 'CDH2'], ['PTK2', 'COMPLEX:P19838_Q04864', 'CDH2'], ['PTK2', 'COMPLEX:Q00653_Q01201', 'CDH2'], ['PTK2', 'SRC', 'CDH2'], ['PTK2', 'RELA', 'CDH2'], ['PTK2', 'NFKB1', 'CDH2'], ['PTK2', 'COMPLEX:Q00653_Q04206', 'CDH2'], ['PTK2', 'COMPLEX:P19838_Q04206', 'CDH2'], ['PTK2', 'COMPLEX:P19838_Q01201', 'CDH2'], ['PTK2', 'COMPLEX:Q04206_Q04864', 'CDH2'], ['PTK2', 'COMPLEX:P19838_Q00653', 'CDH2'], ['PTK2', 'REL', 'CDH2'], ['PTK2', 'COMPLEX:Q01201_Q04206', 'CDH2'], ['PTK2', 'COMPLEX:Q01201_Q04864', 'CDH2'], ['PTK2', 'NFKB2', 'CDH2'], ['PTK2', 'COMPLEX:Q00653_Q04864', 'CDH2']]\n", + "looking for paths in the network with length: 0 for node PTK2 and VIM\n", + "looking for paths in the network with length: 1 for node PTK2 and VIM\n", + "looking for paths in the network with length: 2 for node PTK2 and VIM\n", + "Found a path!\n", + "[['PTK2', 'RELB', 'VIM'], ['PTK2', 'COMPLEX:P19838_Q04864', 'VIM'], ['PTK2', 'COMPLEX:Q00653_Q01201', 'VIM'], ['PTK2', 'RELA', 'VIM'], ['PTK2', 'NFKB1', 'VIM'], ['PTK2', 'COMPLEX:Q00653_Q04206', 'VIM'], ['PTK2', 'COMPLEX:P19838_Q04206', 'VIM'], ['PTK2', 'COMPLEX:P19838_Q01201', 'VIM'], ['PTK2', 'COMPLEX:Q04206_Q04864', 'VIM'], ['PTK2', 'COMPLEX:P19838_Q00653', 'VIM'], ['PTK2', 'REL', 'VIM'], ['PTK2', 'COMPLEX:Q01201_Q04206', 'VIM'], ['PTK2', 'COMPLEX:Q01201_Q04864', 'VIM'], ['PTK2', 'NFKB2', 'VIM'], ['PTK2', 'COMPLEX:Q00653_Q04864', 'VIM']]\n", + "looking for paths in the network with length: 0 for node PTK2 and MAP4K4\n", + "looking for paths in the network with length: 1 for node PTK2 and MAP4K4\n", + "looking for paths in the network with length: 2 for node PTK2 and MAP4K4\n", + "Found a path!\n", + "[['PTK2', 'EPHB1', 'MAP4K4']]\n", + "looking for paths in the network with length: 0 for node PTK2 and PTK2B\n", + "looking for paths in the network with length: 1 for node PTK2 and PTK2B\n", + "Found a path!\n", + "[['PTK2', 'PTK2B']]\n", + "looking for paths in the network with length: 0 for node PTK2 and COL1A1\n", + "looking for paths in the network with length: 1 for node PTK2 and COL1A1\n", + "looking for paths in the network with length: 2 for node PTK2 and COL1A1\n", + "Found a path!\n", + "[['PTK2', 'SRC', 'COL1A1']]\n", + "looking for paths in the network with length: 0 for node CDH1 and CDH2\n", + "looking for paths in the network with length: 1 for node CDH1 and CDH2\n", + "looking for paths in the network with length: 2 for node CDH1 and CDH2\n", + "Found a path!\n", + "[['CDH1', 'COMPLEX:P15407_P17275', 'CDH2'], ['CDH1', 'COMPLEX:P05412_P53539', 'CDH2'], ['CDH1', 'COMPLEX:P05412_P17535', 'CDH2'], ['CDH1', 'COMPLEX:P17275_P53539', 'CDH2'], ['CDH1', 'COMPLEX:P05412_P15407', 'CDH2'], ['CDH1', 'COMPLEX:P05412_P17275', 'CDH2'], ['CDH1', 'COMPLEX:P01100_P17275', 'CDH2'], ['CDH1', 'NFKB1', 'CDH2'], ['CDH1', 'COMPLEX:P19838_Q04206', 'CDH2'], ['CDH1', 'JUND', 'CDH2'], ['CDH1', 'COMPLEX:P19838_Q00653', 'CDH2'], ['CDH1', 'REL', 'CDH2'], ['CDH1', 'COMPLEX:Q01201_Q04206', 'CDH2'], ['CDH1', 'COMPLEX:Q01201_Q04864', 'CDH2'], ['CDH1', 'NFKB2', 'CDH2'], ['CDH1', 'RELB', 'CDH2'], ['CDH1', 'COMPLEX:P05412_P15408', 'CDH2'], ['CDH1', 'COMPLEX:P19838_Q04864', 'CDH2'], ['CDH1', 'COMPLEX:Q00653_Q01201', 'CDH2'], ['CDH1', 'COMPLEX:P01100_P05412', 'CDH2'], ['CDH1', 'COMPLEX:P17535_P53539', 'CDH2'], ['CDH1', 'SRC', 'CDH2'], ['CDH1', 'COMPLEX:P15408_P17535', 'CDH2'], ['CDH1', 'JUN', 'CDH2'], ['CDH1', 'JUNB', 'CDH2'], ['CDH1', 'RELA', 'CDH2'], ['CDH1', 'PPARG', 'CDH2'], ['CDH1', 'COMPLEX:Q00653_Q04206', 'CDH2'], ['CDH1', 'COMPLEX:P19838_Q01201', 'CDH2'], ['CDH1', 'COMPLEX:P15408_P17275', 'CDH2'], ['CDH1', 'COMPLEX:P01100_P17535', 'CDH2'], ['CDH1', 'COMPLEX:Q04206_Q04864', 'CDH2'], ['CDH1', 'COMPLEX:P15407_P17535', 'CDH2'], ['CDH1', 'COMPLEX:P17275_P17535', 'CDH2'], ['CDH1', 'COMPLEX:Q00653_Q04864', 'CDH2']]\n", + "looking for paths in the network with length: 0 for node CDH1 and VIM\n", + "looking for paths in the network with length: 1 for node CDH1 and VIM\n", + "looking for paths in the network with length: 2 for node CDH1 and VIM\n", + "Found a path!\n", + "[['CDH1', 'COMPLEX:P15407_P17275', 'VIM'], ['CDH1', 'COMPLEX:P05412_P53539', 'VIM'], ['CDH1', 'COMPLEX:P05412_P17535', 'VIM'], ['CDH1', 'COMPLEX:P17275_P53539', 'VIM'], ['CDH1', 'COMPLEX:P05412_P15407', 'VIM'], ['CDH1', 'COMPLEX:P05412_P17275', 'VIM'], ['CDH1', 'COMPLEX:P01100_P17275', 'VIM'], ['CDH1', 'NFKB1', 'VIM'], ['CDH1', 'COMPLEX:P19838_Q04206', 'VIM'], ['CDH1', 'JUND', 'VIM'], ['CDH1', 'COMPLEX:P19838_Q00653', 'VIM'], ['CDH1', 'REL', 'VIM'], ['CDH1', 'COMPLEX:Q01201_Q04206', 'VIM'], ['CDH1', 'COMPLEX:Q01201_Q04864', 'VIM'], ['CDH1', 'NFKB2', 'VIM'], ['CDH1', 'RELB', 'VIM'], ['CDH1', 'COMPLEX:P05412_P15408', 'VIM'], ['CDH1', 'COMPLEX:P19838_Q04864', 'VIM'], ['CDH1', 'COMPLEX:Q00653_Q01201', 'VIM'], ['CDH1', 'COMPLEX:P01100_P05412', 'VIM'], ['CDH1', 'COMPLEX:P17535_P53539', 'VIM'], ['CDH1', 'COMPLEX:P15408_P17535', 'VIM'], ['CDH1', 'JUN', 'VIM'], ['CDH1', 'JUNB', 'VIM'], ['CDH1', 'RELA', 'VIM'], ['CDH1', 'COMPLEX:Q00653_Q04206', 'VIM'], ['CDH1', 'COMPLEX:P19838_Q01201', 'VIM'], ['CDH1', 'COMPLEX:P15408_P17275', 'VIM'], ['CDH1', 'COMPLEX:P01100_P17535', 'VIM'], ['CDH1', 'COMPLEX:Q04206_Q04864', 'VIM'], ['CDH1', 'COMPLEX:P15407_P17535', 'VIM'], ['CDH1', 'COMPLEX:P17275_P17535', 'VIM'], ['CDH1', 'COMPLEX:Q00653_Q04864', 'VIM']]\n", + "looking for paths in the network with length: 0 for node CDH1 and MAP4K4\n", + "looking for paths in the network with length: 1 for node CDH1 and MAP4K4\n", + "looking for paths in the network with length: 2 for node CDH1 and MAP4K4\n", + "Found a path!\n", + "[['CDH1', 'PPARG', 'MAP4K4']]\n", + "looking for paths in the network with length: 0 for node CDH1 and PTK2B\n", + "looking for paths in the network with length: 1 for node CDH1 and PTK2B\n", + "looking for paths in the network with length: 2 for node CDH1 and PTK2B\n", + "Found a path!\n", + "[['CDH1', 'COMPLEX:P15407_P17275', 'PTK2B'], ['CDH1', 'COMPLEX:P05412_P53539', 'PTK2B'], ['CDH1', 'COMPLEX:P05412_P17535', 'PTK2B'], ['CDH1', 'COMPLEX:P17275_P53539', 'PTK2B'], ['CDH1', 'COMPLEX:P05412_P15407', 'PTK2B'], ['CDH1', 'COMPLEX:P05412_P17275', 'PTK2B'], ['CDH1', 'COMPLEX:P01100_P17275', 'PTK2B'], ['CDH1', 'JUND', 'PTK2B'], ['CDH1', 'COMPLEX:P05412_P15408', 'PTK2B'], ['CDH1', 'COMPLEX:P01100_P05412', 'PTK2B'], ['CDH1', 'COMPLEX:P17535_P53539', 'PTK2B'], ['CDH1', 'SRC', 'PTK2B'], ['CDH1', 'COMPLEX:P15408_P17535', 'PTK2B'], ['CDH1', 'JUN', 'PTK2B'], ['CDH1', 'JUNB', 'PTK2B'], ['CDH1', 'COMPLEX:P15408_P17275', 'PTK2B'], ['CDH1', 'COMPLEX:P01100_P17535', 'PTK2B'], ['CDH1', 'COMPLEX:P15407_P17535', 'PTK2B'], ['CDH1', 'COMPLEX:P17275_P17535', 'PTK2B']]\n", + "looking for paths in the network with length: 0 for node CDH1 and COL1A1\n", + "looking for paths in the network with length: 1 for node CDH1 and COL1A1\n", + "looking for paths in the network with length: 2 for node CDH1 and COL1A1\n", + "Found a path!\n", + "[['CDH1', 'SRC', 'COL1A1']]\n", + "looking for paths in the network with length: 0 for node CDH2 and VIM\n", + "looking for paths in the network with length: 1 for node CDH2 and VIM\n", + "looking for paths in the network with length: 2 for node CDH2 and VIM\n", + "Found a path!\n", + "[['CDH2', 'COMPLEX:P15407_P17275', 'VIM'], ['CDH2', 'COMPLEX:P05412_P53539', 'VIM'], ['CDH2', 'COMPLEX:P05412_P17535', 'VIM'], ['CDH2', 'COMPLEX:P17275_P53539', 'VIM'], ['CDH2', 'COMPLEX:P05412_P15407', 'VIM'], ['CDH2', 'COMPLEX:P05412_P17275', 'VIM'], ['CDH2', 'COMPLEX:P01100_P17275', 'VIM'], ['CDH2', 'NFKB1', 'VIM'], ['CDH2', 'COMPLEX:P19838_Q04206', 'VIM'], ['CDH2', 'JUND', 'VIM'], ['CDH2', 'COMPLEX:P19838_Q00653', 'VIM'], ['CDH2', 'REL', 'VIM'], ['CDH2', 'COMPLEX:Q01201_Q04206', 'VIM'], ['CDH2', 'COMPLEX:Q01201_Q04864', 'VIM'], ['CDH2', 'NFKB2', 'VIM'], ['CDH2', 'RELB', 'VIM'], ['CDH2', 'COMPLEX:P05412_P15408', 'VIM'], ['CDH2', 'COMPLEX:P19838_Q04864', 'VIM'], ['CDH2', 'COMPLEX:Q00653_Q01201', 'VIM'], ['CDH2', 'COMPLEX:P01100_P05412', 'VIM'], ['CDH2', 'COMPLEX:P17535_P53539', 'VIM'], ['CDH2', 'COMPLEX:P15408_P17535', 'VIM'], ['CDH2', 'JUN', 'VIM'], ['CDH2', 'JUNB', 'VIM'], ['CDH2', 'RELA', 'VIM'], ['CDH2', 'COMPLEX:Q00653_Q04206', 'VIM'], ['CDH2', 'COMPLEX:P19838_Q01201', 'VIM'], ['CDH2', 'COMPLEX:P15408_P17275', 'VIM'], ['CDH2', 'COMPLEX:P01100_P17535', 'VIM'], ['CDH2', 'COMPLEX:Q04206_Q04864', 'VIM'], ['CDH2', 'COMPLEX:P15407_P17535', 'VIM'], ['CDH2', 'COMPLEX:P17275_P17535', 'VIM'], ['CDH2', 'COMPLEX:Q00653_Q04864', 'VIM']]\n", + "looking for paths in the network with length: 0 for node CDH2 and MAP4K4\n", + "looking for paths in the network with length: 1 for node CDH2 and MAP4K4\n", + "looking for paths in the network with length: 2 for node CDH2 and MAP4K4\n", + "Found a path!\n", + "[['CDH2', 'PPARG', 'MAP4K4']]\n", + "looking for paths in the network with length: 0 for node CDH2 and PTK2B\n", + "looking for paths in the network with length: 1 for node CDH2 and PTK2B\n", + "looking for paths in the network with length: 2 for node CDH2 and PTK2B\n", + "Found a path!\n", + "[['CDH2', 'COMPLEX:P15407_P17275', 'PTK2B'], ['CDH2', 'COMPLEX:P05412_P53539', 'PTK2B'], ['CDH2', 'COMPLEX:P05412_P17535', 'PTK2B'], ['CDH2', 'COMPLEX:P17275_P53539', 'PTK2B'], ['CDH2', 'COMPLEX:P05412_P15407', 'PTK2B'], ['CDH2', 'COMPLEX:P05412_P17275', 'PTK2B'], ['CDH2', 'COMPLEX:P01100_P17275', 'PTK2B'], ['CDH2', 'JUND', 'PTK2B'], ['CDH2', 'COMPLEX:P05412_P15408', 'PTK2B'], ['CDH2', 'COMPLEX:P01100_P05412', 'PTK2B'], ['CDH2', 'COMPLEX:P17535_P53539', 'PTK2B'], ['CDH2', 'SRC', 'PTK2B'], ['CDH2', 'COMPLEX:P15408_P17535', 'PTK2B'], ['CDH2', 'JUN', 'PTK2B'], ['CDH2', 'JUNB', 'PTK2B'], ['CDH2', 'COMPLEX:P15408_P17275', 'PTK2B'], ['CDH2', 'COMPLEX:P01100_P17535', 'PTK2B'], ['CDH2', 'COMPLEX:P15407_P17535', 'PTK2B'], ['CDH2', 'COMPLEX:P17275_P17535', 'PTK2B']]\n", + "looking for paths in the network with length: 0 for node CDH2 and COL1A1\n", + "looking for paths in the network with length: 1 for node CDH2 and COL1A1\n", + "looking for paths in the network with length: 2 for node CDH2 and COL1A1\n", + "Found a path!\n", + "[['CDH2', 'SRC', 'COL1A1'], ['CDH2', 'NOTCH1', 'COL1A1']]\n", + "looking for paths in the network with length: 0 for node VIM and MAP4K4\n", + "looking for paths in the network with length: 1 for node VIM and MAP4K4\n", + "looking for paths in the network with length: 2 for node VIM and MAP4K4\n", + "looking for paths in the network with length: 3 for node VIM and MAP4K4\n", + "Found a path!\n", + "[['VIM', 'STAT5A', 'PPARG', 'MAP4K4'], ['VIM', 'COMPLEX:P15407_P17275', 'PPARG', 'MAP4K4'], ['VIM', 'COMPLEX:P05412_P53539', 'PPARG', 'MAP4K4'], ['VIM', 'COMPLEX:P05412_P17535', 'PPARG', 'MAP4K4'], ['VIM', 'COMPLEX:P17275_P53539', 'PPARG', 'MAP4K4'], ['VIM', 'COMPLEX:P05412_P15407', 'PPARG', 'MAP4K4'], ['VIM', 'COMPLEX:P05412_P17275', 'PPARG', 'MAP4K4'], ['VIM', 'COMPLEX:P01100_P17275', 'PPARG', 'MAP4K4'], ['VIM', 'NFKB1', 'PPARG', 'MAP4K4'], ['VIM', 'COMPLEX:P19838_Q04206', 'PPARG', 'MAP4K4'], ['VIM', 'JUND', 'PPARG', 'MAP4K4'], ['VIM', 'COMPLEX:P19838_Q00653', 'PPARG', 'MAP4K4'], ['VIM', 'REL', 'PPARG', 'MAP4K4'], ['VIM', 'NFKB1', 'MAP3K2', 'MAP4K4'], ['VIM', 'NFKB1', 'PPARG', 'MAP4K4'], ['VIM', 'COMPLEX:Q01201_Q04206', 'PPARG', 'MAP4K4'], ['VIM', 'COMPLEX:Q01201_Q04864', 'PPARG', 'MAP4K4'], ['VIM', 'NFKB2', 'PPARG', 'MAP4K4'], ['VIM', 'RELB', 'PPARG', 'MAP4K4'], ['VIM', 'COMPLEX:P05412_P15408', 'PPARG', 'MAP4K4'], ['VIM', 'COMPLEX:P19838_Q04864', 'PPARG', 'MAP4K4'], ['VIM', 'COMPLEX:Q00653_Q01201', 'PPARG', 'MAP4K4'], ['VIM', 'COMPLEX:P01100_P05412', 'PPARG', 'MAP4K4'], ['VIM', 'COMPLEX:P17535_P53539', 'PPARG', 'MAP4K4'], ['VIM', 'COMPLEX:P15408_P17535', 'PPARG', 'MAP4K4'], ['VIM', 'JUN', 'PPARG', 'MAP4K4'], ['VIM', 'JUNB', 'PPARG', 'MAP4K4'], ['VIM', 'RELA', 'PPARG', 'MAP4K4'], ['VIM', 'SP1', 'EPHB1', 'MAP4K4'], ['VIM', 'SP1', 'PPARG', 'MAP4K4'], ['VIM', 'COMPLEX:Q00653_Q04206', 'PPARG', 'MAP4K4'], ['VIM', 'COMPLEX:P19838_Q01201', 'PPARG', 'MAP4K4'], ['VIM', 'COMPLEX:P15408_P17275', 'PPARG', 'MAP4K4'], ['VIM', 'COMPLEX:P01100_P17535', 'PPARG', 'MAP4K4'], ['VIM', 'COMPLEX:Q04206_Q04864', 'PPARG', 'MAP4K4'], ['VIM', 'COMPLEX:P15407_P17535', 'PPARG', 'MAP4K4'], ['VIM', 'COMPLEX:P17275_P17535', 'PPARG', 'MAP4K4'], ['VIM', 'COMPLEX:Q00653_Q04864', 'PPARG', 'MAP4K4']]\n", + "looking for paths in the network with length: 0 for node VIM and PTK2B\n", + "looking for paths in the network with length: 1 for node VIM and PTK2B\n", + "looking for paths in the network with length: 2 for node VIM and PTK2B\n", + "Found a path!\n", + "[['VIM', 'COMPLEX:P15407_P17275', 'PTK2B'], ['VIM', 'COMPLEX:P05412_P53539', 'PTK2B'], ['VIM', 'COMPLEX:P05412_P17535', 'PTK2B'], ['VIM', 'COMPLEX:P17275_P53539', 'PTK2B'], ['VIM', 'COMPLEX:P05412_P15407', 'PTK2B'], ['VIM', 'COMPLEX:P05412_P17275', 'PTK2B'], ['VIM', 'COMPLEX:P01100_P17275', 'PTK2B'], ['VIM', 'JUND', 'PTK2B'], ['VIM', 'COMPLEX:P05412_P15408', 'PTK2B'], ['VIM', 'COMPLEX:P01100_P05412', 'PTK2B'], ['VIM', 'COMPLEX:P17535_P53539', 'PTK2B'], ['VIM', 'COMPLEX:P15408_P17535', 'PTK2B'], ['VIM', 'JUN', 'PTK2B'], ['VIM', 'JUNB', 'PTK2B'], ['VIM', 'COMPLEX:P15408_P17275', 'PTK2B'], ['VIM', 'COMPLEX:P01100_P17535', 'PTK2B'], ['VIM', 'COMPLEX:P15407_P17535', 'PTK2B'], ['VIM', 'COMPLEX:P17275_P17535', 'PTK2B']]\n", + "looking for paths in the network with length: 0 for node VIM and COL1A1\n", + "looking for paths in the network with length: 1 for node VIM and COL1A1\n", + "looking for paths in the network with length: 2 for node VIM and COL1A1\n", + "Found a path!\n", + "[['VIM', 'SP3', 'COL1A1'], ['VIM', 'NFKB1', 'COL1A1'], ['VIM', 'SP1', 'COL1A1']]\n", + "looking for paths in the network with length: 0 for node MAP4K4 and PTK2B\n", + "looking for paths in the network with length: 1 for node MAP4K4 and PTK2B\n", + "looking for paths in the network with length: 2 for node MAP4K4 and PTK2B\n" + ] + }, + { + "name": "stdout", + "output_type": "stream", + "text": [ + "looking for paths in the network with length: 3 for node MAP4K4 and PTK2B\n", + "Found a path!\n", + "[['MAP4K4', 'EPHB1', 'PTK2', 'PTK2B'], ['MAP4K4', 'EPHB1', 'SRC', 'PTK2B'], ['MAP4K4', 'PPARG', 'COMPLEX:P15407_P17275', 'PTK2B'], ['MAP4K4', 'PPARG', 'COMPLEX:P05412_P53539', 'PTK2B'], ['MAP4K4', 'PPARG', 'COMPLEX:P05412_P17535', 'PTK2B'], ['MAP4K4', 'PPARG', 'COMPLEX:P17275_P53539', 'PTK2B'], ['MAP4K4', 'PPARG', 'COMPLEX:P05412_P15407', 'PTK2B'], ['MAP4K4', 'PPARG', 'COMPLEX:P05412_P17275', 'PTK2B'], ['MAP4K4', 'PPARG', 'COMPLEX:P01100_P17275', 'PTK2B'], ['MAP4K4', 'PPARG', 'JUND', 'PTK2B'], ['MAP4K4', 'PPARG', 'COMPLEX:P05412_P15408', 'PTK2B'], ['MAP4K4', 'PPARG', 'COMPLEX:P01100_P05412', 'PTK2B'], ['MAP4K4', 'PPARG', 'COMPLEX:P17535_P53539', 'PTK2B'], ['MAP4K4', 'PPARG', 'SRC', 'PTK2B'], ['MAP4K4', 'PPARG', 'COMPLEX:P15408_P17535', 'PTK2B'], ['MAP4K4', 'PPARG', 'JUN', 'PTK2B'], ['MAP4K4', 'PPARG', 'JUNB', 'PTK2B'], ['MAP4K4', 'PPARG', 'COMPLEX:P15408_P17275', 'PTK2B'], ['MAP4K4', 'PPARG', 'COMPLEX:P01100_P17535', 'PTK2B'], ['MAP4K4', 'PPARG', 'COMPLEX:P15407_P17535', 'PTK2B'], ['MAP4K4', 'PPARG', 'COMPLEX:P17275_P17535', 'PTK2B'], ['MAP4K4', 'MAP3K2', 'SRC', 'PTK2B']]\n", + "looking for paths in the network with length: 0 for node MAP4K4 and COL1A1\n", + "looking for paths in the network with length: 1 for node MAP4K4 and COL1A1\n", + "looking for paths in the network with length: 2 for node MAP4K4 and COL1A1\n", + "looking for paths in the network with length: 3 for node MAP4K4 and COL1A1\n", + "Found a path!\n", + "[['MAP4K4', 'EPHB1', 'SP1', 'COL1A1'], ['MAP4K4', 'EPHB1', 'SRC', 'COL1A1'], ['MAP4K4', 'PPARG', 'NFKB1', 'COL1A1'], ['MAP4K4', 'PPARG', 'SRC', 'COL1A1'], ['MAP4K4', 'PPARG', 'NOTCH1', 'COL1A1'], ['MAP4K4', 'PPARG', 'SP1', 'COL1A1'], ['MAP4K4', 'MAP3K2', 'NFKB1', 'COL1A1'], ['MAP4K4', 'MAP3K2', 'SRC', 'COL1A1']]\n", + "looking for paths in the network with length: 0 for node PTK2B and COL1A1\n", + "looking for paths in the network with length: 1 for node PTK2B and COL1A1\n", + "looking for paths in the network with length: 2 for node PTK2B and COL1A1\n", + "Found a path!\n", + "[['PTK2B', 'SRC', 'COL1A1']]\n", + "CPU times: user 2min 4s, sys: 36.8 ms, total: 2min 4s\n", + "Wall time: 2min 4s\n" + ] + } + ], + "source": [ + "%%time\n", + "new_net1.complete_connection(mode=\"ALL\", maxlen=6, k_mean=\"tight\", only_signed=True,\n", + " consensus=True, connect_node_when_first_introduced=True)" + ] + }, + { + "cell_type": "code", + "execution_count": 17, + "id": "db61c89d", + "metadata": {}, + "outputs": [ + { + "data": { + "image/svg+xml": [ + "\n", + "\n", + "\n", + "\n", + "\n", + "\n", + "%3\n", + "\n", + "\n", + "\n", + "SRC\n", + "\n", + "SRC\n", + "\n", + "\n", + "\n", + "PTK2\n", + "\n", + "PTK2\n", + "\n", + "\n", + "\n", + "SRC->PTK2\n", + "\n", + "\n", + "\n", + "\n", + "\n", + "CDH2\n", + "\n", + "CDH2\n", + "\n", + "\n", + "\n", + "SRC->CDH2\n", + "\n", + "\n", + "\n", + "\n", + "\n", + "\n", + "PTK2B\n", + "\n", + "PTK2B\n", + "\n", + "\n", + "\n", + "SRC->PTK2B\n", + "\n", + "\n", 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+ "\n", + "\n", + "\n", + "\n", + "NFKB2->HNF4A\n", + "\n", + "\n", + "\n", + "\n", + "\n", + "\n", + "NFKB2->PPARG\n", + "\n", + "\n", + "\n", + "\n", + "\n", + "\n", + "Q00653_Q04864\n", + "\n", + "Q00653_Q04864\n", + "\n", + "\n", + "\n", + "Q00653_Q04864->SRC\n", + "\n", + "\n", + "\n", + "\n", + "\n", + "Q00653_Q04864->PTK2\n", + "\n", + "\n", + "\n", + "\n", + "\n", + "Q00653_Q04864->CDH1\n", + "\n", + "\n", + "\n", + "\n", + "\n", + "Q00653_Q04864->CDH2\n", + "\n", + "\n", + "\n", + "\n", + "\n", + "Q00653_Q04864->NOTCH1\n", + "\n", + "\n", + "\n", + "\n", + "\n", + "Q00653_Q04864->VIM\n", + "\n", + "\n", + "\n", + "\n", + "\n", + "Q00653_Q04864->NFKB1\n", + "\n", + "\n", + "\n", + "\n", + "\n", + "Q00653_Q04864->SP1\n", + "\n", + "\n", + "\n", + "\n", + "\n", + "Q00653_Q04864->SP3\n", + "\n", + "\n", + "\n", + "\n", + "\n", + "Q00653_Q04864->STAT5A\n", + "\n", + "\n", + "\n", + "\n", + "\n", + "Q00653_Q04864->HNF4A\n", + "\n", + "\n", + "\n", + "\n", + "\n", + "\n", + "Q00653_Q04864->PPARG\n", + "\n", + "\n", + "\n", + "\n", + "\n", + "\n", + "Q01201_Q04206\n", + "\n", + "Q01201_Q04206\n", + "\n", + "\n", + "\n", + "Q01201_Q04206->SRC\n", + "\n", + "\n", + "\n", + "\n", + "\n", + "Q01201_Q04206->PTK2\n", + "\n", + "\n", + "\n", + "\n", + "\n", + "Q01201_Q04206->CDH1\n", + "\n", + "\n", + "\n", + "\n", + "\n", + "Q01201_Q04206->CDH2\n", + "\n", + "\n", + "\n", + "\n", + "\n", + "Q01201_Q04206->NOTCH1\n", + "\n", + "\n", + "\n", + "\n", + "\n", + "Q01201_Q04206->VIM\n", + "\n", + "\n", + "\n", + "\n", + "\n", + "Q01201_Q04206->NFKB1\n", + "\n", + "\n", + "\n", + "\n", + "\n", + "Q01201_Q04206->SP1\n", + "\n", + "\n", + "\n", + "\n", + "\n", + "Q01201_Q04206->SP3\n", + "\n", + "\n", + "\n", + "\n", + "\n", + "Q01201_Q04206->STAT5A\n", + "\n", + "\n", + "\n", + "\n", + "\n", + "Q01201_Q04206->HNF4A\n", + "\n", + "\n", + "\n", + "\n", + "\n", + "\n", + "Q01201_Q04206->PPARG\n", + "\n", + "\n", + "\n", + "\n", + "\n", + "\n", + "P05412_P15408\n", + "\n", + "P05412_P15408\n", + "\n", + "\n", + "\n", + "P05412_P15408->SRC\n", + "\n", + "\n", + "\n", + "\n", + "\n", + "P05412_P15408->CDH1\n", + "\n", + "\n", + "\n", + "\n", + "\n", + "P05412_P15408->CDH2\n", + "\n", + "\n", + "\n", + "\n", + "\n", + "\n", + "P05412_P15408->PTK2B\n", + "\n", + "\n", + "\n", + "\n", + "\n", + "P05412_P15408->VIM\n", + "\n", + "\n", + "\n", + "\n", + "\n", + "P05412_P15408->NFKB1\n", + "\n", + "\n", + "\n", + "\n", + "\n", + "\n", + "P05412_P15408->SP1\n", + "\n", + "\n", + "\n", + "\n", + "\n", + "P05412_P15408->SP3\n", + "\n", + "\n", + "\n", + "\n", + "\n", + "P05412_P15408->PPARG\n", + "\n", + "\n", + "\n", + "\n", + "\n", + "\n", + "P17275_P17535\n", + "\n", + "P17275_P17535\n", + "\n", + "\n", + "\n", + "P17275_P17535->SRC\n", + "\n", + "\n", + "\n", + "\n", + "\n", + "P17275_P17535->CDH1\n", + "\n", + "\n", + "\n", + "\n", + "\n", + "P17275_P17535->CDH2\n", + "\n", + "\n", + "\n", + "\n", + "\n", + "\n", + "P17275_P17535->PTK2B\n", + "\n", + "\n", + "\n", + "\n", + "\n", + "P17275_P17535->VIM\n", + "\n", + "\n", + "\n", + "\n", + "\n", + "P17275_P17535->NFKB1\n", + "\n", + "\n", + "\n", + "\n", + "\n", + "\n", + "P17275_P17535->SP1\n", + "\n", + "\n", + "\n", + "\n", + "\n", + "P17275_P17535->SP3\n", + "\n", + "\n", + "\n", + "\n", + "\n", + "P17275_P17535->PPARG\n", + "\n", + "\n", + "\n", + "\n", + "\n", + "\n", + "MAP3K2->NFKB1\n", + "\n", + "\n", + "\n", + "\n", + "\n", + "MAP4K4\n", + "\n", + "MAP4K4\n", + "\n", + "\n", + "\n", + "MAP4K4->MAP3K2\n", + "\n", + "\n", + "\n", + "\n", + "\n", + "EPHB1->SRC\n", + "\n", + "\n", + "\n", + "\n", + "\n", + "EPHB1->PTK2\n", + "\n", + "\n", + "\n", + "\n", + "\n", + "\n", + "EPHB1->MAP4K4\n", + "\n", + "\n", + "\n", + "\n", + "\n", + "PPARG->CDH1\n", + "\n", + "\n", + "\n", + "\n", + "\n", + "PPARG->CDH2\n", + "\n", + "\n", + "\n", + "\n", + "\n", + "\n", + "PPARG->NFKB1\n", + "\n", + "\n", + "\n", + "\n", + "\n", + "\n", + "PPARG->SP1\n", + "\n", + "\n", + "\n", + "\n", + "\n", + "PPARG->STAT5A\n", + "\n", + "\n", + "\n", + "\n", + "\n", + "\n", + "PPARG->MAP4K4\n", + "\n", + "\n", + "\n", + "\n", + "\n", + "\n" + ], + "text/plain": [ + "" + ] + }, + "metadata": {}, + "output_type": "display_data" + } + ], + "source": [ + "visualizer = NetworkVisualizer(new_net1, color_by='effect')\n", + "visualizer.render()" + ] + }, + { + "cell_type": "markdown", + "id": "57cabbaa", + "metadata": {}, + "source": [ + "### We can access the network object edges to explore which interactions are in our network" + ] + }, + { + "cell_type": "markdown", + "id": "8361d2b2-646b-4080-bc36-ca28c9bfab10", + "metadata": {}, + "source": [ + "## The whole tool, as the name suggest, is based on Omnipath. But the user can also integrate its own databases. As example, we show how to integrate the Signor database. In order to do so, the User needs to have already downloaded the whole Signor database, available at the following link: https://signor.uniroma2.it/downloads.php \n", + "## Omniflow has been conceived to be a modular tool, with the possibility to add new databases. Every time a User wants to add a database, it should prepare an apposite function in the Resources module, in order to convert the target database, in the Omniflow format. We suggest to use as example, the function created for the Signor database. In future releases we plan to add more function to include more databases." + ] + }, + { + "cell_type": "code", + "execution_count": 16, + "id": "4fd4b190-350a-4682-8f09-8c6423064038", + "metadata": {}, + "outputs": [], + "source": [ + "resources = Resources()\n", + "resources.import_signor_tsv(\"./all_data_18_03_24.tsv\") # this function accept only tab separated values" + ] + }, + { + "cell_type": "code", + "execution_count": 23, + "id": "1ee6984a-1a6e-410e-b335-9acc1359b359", + "metadata": {}, + "outputs": [ + { + "name": "stdout", + "output_type": "stream", + "text": [ + "CPU times: user 32.3 ms, sys: 2 µs, total: 32.3 ms\n", + "Wall time: 31.6 ms\n" + ] + } + ], + "source": [ + "%%time\n", + "new_net1 = Network(genes, resources=resources.interactions) # here we load the signor interactions" + ] + }, + { + "cell_type": "markdown", + "id": "7aae5ca7-5696-44ba-9e75-4a2d1eb0a2d9", + "metadata": {}, + "source": [ + "## It is important to note, that not all the databases have the same structure as Omnipath. In particular, if the columns \"consensus\" are missing, we suggest to avoid to use the flag \"consensus\" or \"consensus_only\" when using Omniflow with customize databases." + ] + }, + { + "cell_type": "code", + "execution_count": 24, + "id": "12052b3b-854f-41a0-a762-20de5cbc7b35", + "metadata": {}, + "outputs": [ + { + "name": "stdout", + "output_type": "stream", + "text": [ + "looking for paths in the network with length: 0 for node FOXA1 and GRHL1\n", + "looking for paths in the network with length: 1 for node FOXA1 and GRHL1\n", + "looking for paths in the network with length: 2 for node FOXA1 and GRHL1\n", + "looking for paths in the network with length: 3 for node FOXA1 and GRHL1\n", + "looking for paths in the network with length: 4 for node FOXA1 and GRHL1\n", + "looking for paths in the network with length: 5 for node FOXA1 and GRHL1\n", + "looking for paths in the network with length: 6 for node FOXA1 and GRHL1\n", + "i_search = 3\n", + "Looking for paths with length: 0 for node FOXA1 and GRHL1\n", + "i_search = 3\n", + "Looking for paths with length: 1 for node FOXA1 and GRHL1\n", + "i_search = 3\n", + "Looking for paths with length: 2 for node FOXA1 and GRHL1\n", + "i_search = 3\n", + "Looking for paths with length: 3 for node FOXA1 and GRHL1\n", + "looking for paths in the network with length: 0 for node FOXA1 and GRHL3\n", + "looking for paths in the network with length: 1 for node FOXA1 and GRHL3\n", + "looking for paths in the network with length: 2 for node FOXA1 and GRHL3\n", + "looking for paths in the network with length: 3 for node FOXA1 and GRHL3\n", + "looking for paths in the network with length: 4 for node FOXA1 and GRHL3\n", + "looking for paths in the network with length: 5 for node FOXA1 and GRHL3\n", + "looking for paths in the network with length: 6 for node FOXA1 and GRHL3\n", + "i_search = 3\n", + "Looking for paths with length: 0 for node FOXA1 and GRHL3\n", + "i_search = 3\n", + "Looking for paths with length: 1 for node FOXA1 and GRHL3\n", + "i_search = 3\n", + "Looking for paths with length: 2 for node FOXA1 and GRHL3\n", + "i_search = 3\n", + "Looking for paths with length: 3 for node FOXA1 and GRHL3\n", + "looking for paths in the network with length: 0 for node FOXA1 and EHF\n", + "looking for paths in the network with length: 1 for node FOXA1 and EHF\n", + "looking for paths in the network with length: 2 for node FOXA1 and EHF\n", + "looking for paths in the network with length: 3 for node FOXA1 and EHF\n", + "looking for paths in the network with length: 4 for node FOXA1 and EHF\n", + "looking for paths in the network with length: 5 for node FOXA1 and EHF\n", + "looking for paths in the network with length: 6 for node FOXA1 and EHF\n", + "i_search = 3\n", + "Looking for paths with length: 0 for node FOXA1 and EHF\n", + "i_search = 3\n", + "Looking for paths with length: 1 for node FOXA1 and EHF\n", + "i_search = 3\n", + "Looking for paths with length: 2 for node FOXA1 and EHF\n", + "i_search = 3\n", + "Looking for paths with length: 3 for node FOXA1 and EHF\n", + "looking for paths in the network with length: 0 for node FOXA1 and KLF5\n", + "looking for paths in the network with length: 1 for node FOXA1 and KLF5\n", + "looking for paths in the network with length: 2 for node FOXA1 and KLF5\n", + "looking for paths in the network with length: 3 for node FOXA1 and KLF5\n", + "looking for paths in the network with length: 4 for node FOXA1 and KLF5\n", + "looking for paths in the network with length: 5 for node FOXA1 and KLF5\n", + "looking for paths in the network with length: 6 for node FOXA1 and KLF5\n", + "i_search = 3\n", + "Looking for paths with length: 0 for node FOXA1 and KLF5\n", + "i_search = 3\n", + "Looking for paths with length: 1 for node FOXA1 and KLF5\n", + "i_search = 3\n", + "Looking for paths with length: 2 for node FOXA1 and KLF5\n", + "i_search = 3\n", + "Looking for paths with length: 3 for node FOXA1 and KLF5\n", + "[['FOXA1', 'HSPA1A', 'NR3C1', 'KLF5'], ['FOXA1', 'AR', 'NR3C1', 'KLF5']]\n", + "P55317 P0DMV8\n", + "P0DMV8 P04150\n", + "P04150 Q13887\n", + "P55317 P10275\n", + "P10275 P04150\n", + "P04150 Q13887\n", + "P55317 P0DMV8\n", + "P55317 P10275\n", + "P17676 Q13887\n", + "P04150 Q13887\n", + "P04150 P17676\n", + "P0DMV8 P04150\n", + "P04150 P10275\n", + "P10275 P04150\n", + "looking for paths in the network with length: 0 for node FOXA1 and HOXA9\n", + "looking for paths in the network with length: 1 for node FOXA1 and HOXA9\n", + "looking for paths in the network with length: 2 for node FOXA1 and HOXA9\n", + "looking for paths in the network with length: 3 for node FOXA1 and HOXA9\n", + "looking for paths in the network with length: 4 for node FOXA1 and HOXA9\n", + "looking for paths in the network with length: 5 for node FOXA1 and HOXA9\n", + "looking for paths in the network with length: 6 for node FOXA1 and HOXA9\n", + "i_search = 3\n", + "Looking for paths with length: 0 for node FOXA1 and HOXA9\n", + "i_search = 3\n", + "Looking for paths with length: 1 for node FOXA1 and HOXA9\n", + "i_search = 3\n", + "Looking for paths with length: 2 for node FOXA1 and HOXA9\n", + "i_search = 3\n", + "Looking for paths with length: 3 for node FOXA1 and HOXA9\n", + "[['FOXA1', 'NFIB', 'EZH2', 'HOXA9']]\n", + "P55317 O00712\n", + "O00712 Q15910\n", + "Q15910 P31269\n", + "P55317 P0DMV8\n", + "P55317 P10275\n", + "P55317 O00712\n", + "P17676 Q13887\n", + "P04150 Q13887\n", + "Q15910 P31269\n", + "Q15910 P31260\n", + "O00712 P41161\n", + "P04150 P17676\n", + "P0DMV8 P04150\n", + "P04150 P10275\n", + "P10275 P04150\n", + "Q15910 P10275\n", + "O00712 Q15910\n", + "looking for paths in the network with length: 0 for node FOXA1 and HOXA10\n", + "looking for paths in the network with length: 1 for node FOXA1 and HOXA10\n", + "looking for paths in the network with length: 2 for node FOXA1 and HOXA10\n", + "looking for paths in the network with length: 3 for node FOXA1 and HOXA10\n", + "Found a path!\n", + "[['FOXA1', 'NFIB', 'EZH2', 'HOXA10']]\n", + "looking for paths in the network with length: 0 for node FOXA1 and ETV4\n", + "looking for paths in the network with length: 1 for node FOXA1 and ETV4\n", + "looking for paths in the network with length: 2 for node FOXA1 and ETV4\n", + "looking for paths in the network with length: 3 for node FOXA1 and ETV4\n", + "looking for paths in the network with length: 4 for node FOXA1 and ETV4\n", + "looking for paths in the network with length: 5 for node FOXA1 and ETV4\n", + "looking for paths in the network with length: 6 for node FOXA1 and ETV4\n", + "i_search = 3\n", + "Looking for paths with length: 0 for node FOXA1 and ETV4\n", + "i_search = 3\n", + "Looking for paths with length: 1 for node FOXA1 and ETV4\n", + "i_search = 3\n", + "Looking for paths with length: 2 for node FOXA1 and ETV4\n", + "i_search = 3\n", + "Looking for paths with length: 3 for node FOXA1 and ETV4\n", + "looking for paths in the network with length: 0 for node FOXA1 and ETV5\n", + "looking for paths in the network with length: 1 for node FOXA1 and ETV5\n", + "looking for paths in the network with length: 2 for node FOXA1 and ETV5\n", + "Found a path!\n", + "[['FOXA1', 'NFIB', 'ETV5']]\n", + "looking for paths in the network with length: 0 for node FOXA1 and POU3F1\n", + "looking for paths in the network with length: 1 for node FOXA1 and POU3F1\n", + "looking for paths in the network with length: 2 for node FOXA1 and POU3F1\n", + "looking for paths in the network with length: 3 for node FOXA1 and POU3F1\n", + "looking for paths in the network with length: 4 for node FOXA1 and POU3F1\n", + "looking for paths in the network with length: 5 for node FOXA1 and POU3F1\n", + "looking for paths in the network with length: 6 for node FOXA1 and POU3F1\n", + "i_search = 3\n", + "Looking for paths with length: 0 for node FOXA1 and POU3F1\n", + "i_search = 3\n", + "Looking for paths with length: 1 for node FOXA1 and POU3F1\n", + "i_search = 3\n", + "Looking for paths with length: 2 for node FOXA1 and POU3F1\n", + "i_search = 3\n", + "Looking for paths with length: 3 for node FOXA1 and POU3F1\n", + "looking for paths in the network with length: 0 for node FOXA1 and CEBPB\n", + "looking for paths in the network with length: 1 for node FOXA1 and CEBPB\n", + "looking for paths in the network with length: 2 for node FOXA1 and CEBPB\n", + "looking for paths in the network with length: 3 for node FOXA1 and CEBPB\n", + "Found a path!\n", + "[['FOXA1', 'HSPA1A', 'NR3C1', 'CEBPB'], ['FOXA1', 'AR', 'NR3C1', 'CEBPB']]\n", + "looking for paths in the network with length: 0 for node GRHL1 and GRHL3\n", + "looking for paths in the network with length: 1 for node GRHL1 and GRHL3\n", + "looking for paths in the network with length: 2 for node GRHL1 and GRHL3\n", + "looking for paths in the network with length: 3 for node GRHL1 and GRHL3\n", + "looking for paths in the network with length: 4 for node GRHL1 and GRHL3\n", + "looking for paths in the network with length: 5 for node GRHL1 and GRHL3\n", + "looking for paths in the network with length: 6 for node GRHL1 and GRHL3\n", + "i_search = 3\n", + "Looking for paths with length: 0 for node GRHL1 and GRHL3\n", + "i_search = 3\n", + "Looking for paths with length: 1 for node GRHL1 and GRHL3\n", + "i_search = 3\n", + "Looking for paths with length: 2 for node GRHL1 and GRHL3\n", + "i_search = 3\n", + "Looking for paths with length: 3 for node GRHL1 and GRHL3\n", + "looking for paths in the network with length: 0 for node GRHL1 and EHF\n", + "looking for paths in the network with length: 1 for node GRHL1 and EHF\n", + "looking for paths in the network with length: 2 for node GRHL1 and EHF\n", + "looking for paths in the network with length: 3 for node GRHL1 and EHF\n", + "looking for paths in the network with length: 4 for node GRHL1 and EHF\n", + "looking for paths in the network with length: 5 for node GRHL1 and EHF\n", + "looking for paths in the network with length: 6 for node GRHL1 and EHF\n", + "i_search = 3\n", + "Looking for paths with length: 0 for node GRHL1 and EHF\n", + "i_search = 3\n", + "Looking for paths with length: 1 for node GRHL1 and EHF\n", + "i_search = 3\n", + "Looking for paths with length: 2 for node GRHL1 and EHF\n", + "i_search = 3\n", + "Looking for paths with length: 3 for node GRHL1 and EHF\n", + "looking for paths in the network with length: 0 for node GRHL1 and KLF5\n", + "looking for paths in the network with length: 1 for node GRHL1 and KLF5\n", + "looking for paths in the network with length: 2 for node GRHL1 and KLF5\n", + "looking for paths in the network with length: 3 for node GRHL1 and KLF5\n", + "looking for paths in the network with length: 4 for node GRHL1 and KLF5\n", + "looking for paths in the network with length: 5 for node GRHL1 and KLF5\n", + "looking for paths in the network with length: 6 for node GRHL1 and KLF5\n", + "i_search = 3\n", + "Looking for paths with length: 0 for node GRHL1 and KLF5\n", + "i_search = 3\n", + "Looking for paths with length: 1 for node GRHL1 and KLF5\n", + "i_search = 3\n", + "Looking for paths with length: 2 for node GRHL1 and KLF5\n", + "i_search = 3\n", + "Looking for paths with length: 3 for node GRHL1 and KLF5\n", + "looking for paths in the network with length: 0 for node GRHL1 and HOXA9\n", + "looking for paths in the network with length: 1 for node GRHL1 and HOXA9\n", + "looking for paths in the network with length: 2 for node GRHL1 and HOXA9\n", + "looking for paths in the network with length: 3 for node GRHL1 and HOXA9\n", + "looking for paths in the network with length: 4 for node GRHL1 and HOXA9\n", + "looking for paths in the network with length: 5 for node GRHL1 and HOXA9\n", + "looking for paths in the network with length: 6 for node GRHL1 and HOXA9\n", + "i_search = 3\n", + "Looking for paths with length: 0 for node GRHL1 and HOXA9\n", + "i_search = 3\n", + "Looking for paths with length: 1 for node GRHL1 and HOXA9\n", + "i_search = 3\n", + "Looking for paths with length: 2 for node GRHL1 and HOXA9\n", + "i_search = 3\n", + "Looking for paths with length: 3 for node GRHL1 and HOXA9\n", + "looking for paths in the network with length: 0 for node GRHL1 and HOXA10\n", + "looking for paths in the network with length: 1 for node GRHL1 and HOXA10\n", + "looking for paths in the network with length: 2 for node GRHL1 and HOXA10\n", + "looking for paths in the network with length: 3 for node GRHL1 and HOXA10\n", + "looking for paths in the network with length: 4 for node GRHL1 and HOXA10\n", + "looking for paths in the network with length: 5 for node GRHL1 and HOXA10\n", + "looking for paths in the network with length: 6 for node GRHL1 and HOXA10\n", + "i_search = 3\n", + "Looking for paths with length: 0 for node GRHL1 and HOXA10\n", + "i_search = 3\n", + "Looking for paths with length: 1 for node GRHL1 and HOXA10\n", + "i_search = 3\n", + "Looking for paths with length: 2 for node GRHL1 and HOXA10\n", + "i_search = 3\n", + "Looking for paths with length: 3 for node GRHL1 and HOXA10\n", + "looking for paths in the network with length: 0 for node GRHL1 and ETV4\n", + "looking for paths in the network with length: 1 for node GRHL1 and ETV4\n", + "looking for paths in the network with length: 2 for node GRHL1 and ETV4\n", + "looking for paths in the network with length: 3 for node GRHL1 and ETV4\n", + "looking for paths in the network with length: 4 for node GRHL1 and ETV4\n", + "looking for paths in the network with length: 5 for node GRHL1 and ETV4\n", + "looking for paths in the network with length: 6 for node GRHL1 and ETV4\n", + "i_search = 3\n", + "Looking for paths with length: 0 for node GRHL1 and ETV4\n", + "i_search = 3\n", + "Looking for paths with length: 1 for node GRHL1 and ETV4\n", + "i_search = 3\n", + "Looking for paths with length: 2 for node GRHL1 and ETV4\n", + "i_search = 3\n", + "Looking for paths with length: 3 for node GRHL1 and ETV4\n", + "looking for paths in the network with length: 0 for node GRHL1 and ETV5\n", + "looking for paths in the network with length: 1 for node GRHL1 and ETV5\n", + "looking for paths in the network with length: 2 for node GRHL1 and ETV5\n", + "looking for paths in the network with length: 3 for node GRHL1 and ETV5\n", + "looking for paths in the network with length: 4 for node GRHL1 and ETV5\n", + "looking for paths in the network with length: 5 for node GRHL1 and ETV5\n", + "looking for paths in the network with length: 6 for node GRHL1 and ETV5\n", + "i_search = 3\n", + "Looking for paths with length: 0 for node GRHL1 and ETV5\n", + "i_search = 3\n", + "Looking for paths with length: 1 for node GRHL1 and ETV5\n", + "i_search = 3\n", + "Looking for paths with length: 2 for node GRHL1 and ETV5\n", + "i_search = 3\n", + "Looking for paths with length: 3 for node GRHL1 and ETV5\n", + "looking for paths in the network with length: 0 for node GRHL1 and POU3F1\n", + "looking for paths in the network with length: 1 for node GRHL1 and POU3F1\n", + "looking for paths in the network with length: 2 for node GRHL1 and POU3F1\n", + "looking for paths in the network with length: 3 for node GRHL1 and POU3F1\n", + "looking for paths in the network with length: 4 for node GRHL1 and POU3F1\n", + "looking for paths in the network with length: 5 for node GRHL1 and POU3F1\n", + "looking for paths in the network with length: 6 for node GRHL1 and POU3F1\n", + "i_search = 3\n", + "Looking for paths with length: 0 for node GRHL1 and POU3F1\n", + "i_search = 3\n", + "Looking for paths with length: 1 for node GRHL1 and POU3F1\n", + "i_search = 3\n", + "Looking for paths with length: 2 for node GRHL1 and POU3F1\n", + "i_search = 3\n", + "Looking for paths with length: 3 for node GRHL1 and POU3F1\n", + "looking for paths in the network with length: 0 for node GRHL1 and CEBPB\n", + "looking for paths in the network with length: 1 for node GRHL1 and CEBPB\n", + "looking for paths in the network with length: 2 for node GRHL1 and CEBPB\n", + "looking for paths in the network with length: 3 for node GRHL1 and CEBPB\n", + "looking for paths in the network with length: 4 for node GRHL1 and CEBPB\n", + "looking for paths in the network with length: 5 for node GRHL1 and CEBPB\n", + "looking for paths in the network with length: 6 for node GRHL1 and CEBPB\n", + "i_search = 3\n", + "Looking for paths with length: 0 for node GRHL1 and CEBPB\n", + "i_search = 3\n", + "Looking for paths with length: 1 for node GRHL1 and CEBPB\n", + "i_search = 3\n", + "Looking for paths with length: 2 for node GRHL1 and CEBPB\n", + "i_search = 3\n", + "Looking for paths with length: 3 for node GRHL1 and CEBPB\n", + "looking for paths in the network with length: 0 for node GRHL3 and EHF\n", + "looking for paths in the network with length: 1 for node GRHL3 and EHF\n", + "looking for paths in the network with length: 2 for node GRHL3 and EHF\n", + "looking for paths in the network with length: 3 for node GRHL3 and EHF\n", + "looking for paths in the network with length: 4 for node GRHL3 and EHF\n", + "looking for paths in the network with length: 5 for node GRHL3 and EHF\n", + "looking for paths in the network with length: 6 for node GRHL3 and EHF\n", + "i_search = 3\n", + "Looking for paths with length: 0 for node GRHL3 and EHF\n", + "i_search = 3\n", + "Looking for paths with length: 1 for node GRHL3 and EHF\n", + "i_search = 3\n", + "Looking for paths with length: 2 for node GRHL3 and EHF\n", + "i_search = 3\n", + "Looking for paths with length: 3 for node GRHL3 and EHF\n", + "looking for paths in the network with length: 0 for node GRHL3 and KLF5\n", + "looking for paths in the network with length: 1 for node GRHL3 and KLF5\n", + "looking for paths in the network with length: 2 for node GRHL3 and KLF5\n", + "looking for paths in the network with length: 3 for node GRHL3 and KLF5\n", + "looking for paths in the network with length: 4 for node GRHL3 and KLF5\n", + "looking for paths in the network with length: 5 for node GRHL3 and KLF5\n", + "looking for paths in the network with length: 6 for node GRHL3 and KLF5\n", + "i_search = 3\n", + "Looking for paths with length: 0 for node GRHL3 and KLF5\n", + "i_search = 3\n", + "Looking for paths with length: 1 for node GRHL3 and KLF5\n", + "i_search = 3\n", + "Looking for paths with length: 2 for node GRHL3 and KLF5\n", + "i_search = 3\n", + "Looking for paths with length: 3 for node GRHL3 and KLF5\n", + "looking for paths in the network with length: 0 for node GRHL3 and HOXA9\n", + "looking for paths in the network with length: 1 for node GRHL3 and HOXA9\n", + "looking for paths in the network with length: 2 for node GRHL3 and HOXA9\n", + "looking for paths in the network with length: 3 for node GRHL3 and HOXA9\n", + "looking for paths in the network with length: 4 for node GRHL3 and HOXA9\n", + "looking for paths in the network with length: 5 for node GRHL3 and HOXA9\n", + "looking for paths in the network with length: 6 for node GRHL3 and HOXA9\n", + "i_search = 3\n", + "Looking for paths with length: 0 for node GRHL3 and HOXA9\n", + "i_search = 3\n", + "Looking for paths with length: 1 for node GRHL3 and HOXA9\n", + "i_search = 3\n", + "Looking for paths with length: 2 for node GRHL3 and HOXA9\n", + "i_search = 3\n", + "Looking for paths with length: 3 for node GRHL3 and HOXA9\n", + "looking for paths in the network with length: 0 for node GRHL3 and HOXA10\n", + "looking for paths in the network with length: 1 for node GRHL3 and HOXA10\n", + "looking for paths in the network with length: 2 for node GRHL3 and HOXA10\n", + "looking for paths in the network with length: 3 for node GRHL3 and HOXA10\n", + "looking for paths in the network with length: 4 for node GRHL3 and HOXA10\n", + "looking for paths in the network with length: 5 for node GRHL3 and HOXA10\n", + "looking for paths in the network with length: 6 for node GRHL3 and HOXA10\n", + "i_search = 3\n", + "Looking for paths with length: 0 for node GRHL3 and HOXA10\n", + "i_search = 3\n", + "Looking for paths with length: 1 for node GRHL3 and HOXA10\n", + "i_search = 3\n", + "Looking for paths with length: 2 for node GRHL3 and HOXA10\n", + "i_search = 3\n", + "Looking for paths with length: 3 for node GRHL3 and HOXA10\n", + "looking for paths in the network with length: 0 for node GRHL3 and ETV4\n", + "looking for paths in the network with length: 1 for node GRHL3 and ETV4\n", + "looking for paths in the network with length: 2 for node GRHL3 and ETV4\n", + "looking for paths in the network with length: 3 for node GRHL3 and ETV4\n", + "looking for paths in the network with length: 4 for node GRHL3 and ETV4\n", + "looking for paths in the network with length: 5 for node GRHL3 and ETV4\n", + "looking for paths in the network with length: 6 for node GRHL3 and ETV4\n", + "i_search = 3\n", + "Looking for paths with length: 0 for node GRHL3 and ETV4\n", + "i_search = 3\n", + "Looking for paths with length: 1 for node GRHL3 and ETV4\n", + "i_search = 3\n", + "Looking for paths with length: 2 for node GRHL3 and ETV4\n", + "i_search = 3\n", + "Looking for paths with length: 3 for node GRHL3 and ETV4\n", + "looking for paths in the network with length: 0 for node GRHL3 and ETV5\n", + "looking for paths in the network with length: 1 for node GRHL3 and ETV5\n", + "looking for paths in the network with length: 2 for node GRHL3 and ETV5\n", + "looking for paths in the network with length: 3 for node GRHL3 and ETV5\n", + "looking for paths in the network with length: 4 for node GRHL3 and ETV5\n", + "looking for paths in the network with length: 5 for node GRHL3 and ETV5\n", + "looking for paths in the network with length: 6 for node GRHL3 and ETV5\n", + "i_search = 3\n", + "Looking for paths with length: 0 for node GRHL3 and ETV5\n", + "i_search = 3\n", + "Looking for paths with length: 1 for node GRHL3 and ETV5\n", + "i_search = 3\n", + "Looking for paths with length: 2 for node GRHL3 and ETV5\n", + "i_search = 3\n", + "Looking for paths with length: 3 for node GRHL3 and ETV5\n", + "looking for paths in the network with length: 0 for node GRHL3 and POU3F1\n", + "looking for paths in the network with length: 1 for node GRHL3 and POU3F1\n", + "looking for paths in the network with length: 2 for node GRHL3 and POU3F1\n", + "looking for paths in the network with length: 3 for node GRHL3 and POU3F1\n", + "looking for paths in the network with length: 4 for node GRHL3 and POU3F1\n", + "looking for paths in the network with length: 5 for node GRHL3 and POU3F1\n", + "looking for paths in the network with length: 6 for node GRHL3 and POU3F1\n", + "i_search = 3\n", + "Looking for paths with length: 0 for node GRHL3 and POU3F1\n", + "i_search = 3\n", + "Looking for paths with length: 1 for node GRHL3 and POU3F1\n", + "i_search = 3\n", + "Looking for paths with length: 2 for node GRHL3 and POU3F1\n", + "i_search = 3\n", + "Looking for paths with length: 3 for node GRHL3 and POU3F1\n", + "looking for paths in the network with length: 0 for node GRHL3 and CEBPB\n", + "looking for paths in the network with length: 1 for node GRHL3 and CEBPB\n", + "looking for paths in the network with length: 2 for node GRHL3 and CEBPB\n", + "looking for paths in the network with length: 3 for node GRHL3 and CEBPB\n", + "looking for paths in the network with length: 4 for node GRHL3 and CEBPB\n", + "looking for paths in the network with length: 5 for node GRHL3 and CEBPB\n", + "looking for paths in the network with length: 6 for node GRHL3 and CEBPB\n", + "i_search = 3\n", + "Looking for paths with length: 0 for node GRHL3 and CEBPB\n", + "i_search = 3\n", + "Looking for paths with length: 1 for node GRHL3 and CEBPB\n", + "i_search = 3\n", + "Looking for paths with length: 2 for node GRHL3 and CEBPB\n", + "i_search = 3\n", + "Looking for paths with length: 3 for node GRHL3 and CEBPB\n", + "looking for paths in the network with length: 0 for node EHF and KLF5\n", + "looking for paths in the network with length: 1 for node EHF and KLF5\n", + "looking for paths in the network with length: 2 for node EHF and KLF5\n", + "looking for paths in the network with length: 3 for node EHF and KLF5\n", + "looking for paths in the network with length: 4 for node EHF and KLF5\n", + "looking for paths in the network with length: 5 for node EHF and KLF5\n", + "looking for paths in the network with length: 6 for node EHF and KLF5\n", + "i_search = 3\n", + "Looking for paths with length: 0 for node EHF and KLF5\n", + "i_search = 3\n", + "Looking for paths with length: 1 for node EHF and KLF5\n", + "i_search = 3\n", + "Looking for paths with length: 2 for node EHF and KLF5\n", + "i_search = 3\n", + "Looking for paths with length: 3 for node EHF and KLF5\n", + "looking for paths in the network with length: 0 for node EHF and HOXA9\n", + "looking for paths in the network with length: 1 for node EHF and HOXA9\n", + "looking for paths in the network with length: 2 for node EHF and HOXA9\n", + "looking for paths in the network with length: 3 for node EHF and HOXA9\n", + "looking for paths in the network with length: 4 for node EHF and HOXA9\n", + "looking for paths in the network with length: 5 for node EHF and HOXA9\n", + "looking for paths in the network with length: 6 for node EHF and HOXA9\n", + "i_search = 3\n", + "Looking for paths with length: 0 for node EHF and HOXA9\n", + "i_search = 3\n", + "Looking for paths with length: 1 for node EHF and HOXA9\n", + "i_search = 3\n", + "Looking for paths with length: 2 for node EHF and HOXA9\n", + "i_search = 3\n", + "Looking for paths with length: 3 for node EHF and HOXA9\n", + "looking for paths in the network with length: 0 for node EHF and HOXA10\n", + "looking for paths in the network with length: 1 for node EHF and HOXA10\n", + "looking for paths in the network with length: 2 for node EHF and HOXA10\n", + "looking for paths in the network with length: 3 for node EHF and HOXA10\n", + "looking for paths in the network with length: 4 for node EHF and HOXA10\n", + "looking for paths in the network with length: 5 for node EHF and HOXA10\n", + "looking for paths in the network with length: 6 for node EHF and HOXA10\n", + "i_search = 3\n", + "Looking for paths with length: 0 for node EHF and HOXA10\n", + "i_search = 3\n", + "Looking for paths with length: 1 for node EHF and HOXA10\n", + "i_search = 3\n", + "Looking for paths with length: 2 for node EHF and HOXA10\n", + "i_search = 3\n", + "Looking for paths with length: 3 for node EHF and HOXA10\n", + "looking for paths in the network with length: 0 for node EHF and ETV4\n", + "looking for paths in the network with length: 1 for node EHF and ETV4\n", + "looking for paths in the network with length: 2 for node EHF and ETV4\n", + "looking for paths in the network with length: 3 for node EHF and ETV4\n", + "looking for paths in the network with length: 4 for node EHF and ETV4\n", + "looking for paths in the network with length: 5 for node EHF and ETV4\n", + "looking for paths in the network with length: 6 for node EHF and ETV4\n", + "i_search = 3\n", + "Looking for paths with length: 0 for node EHF and ETV4\n", + "i_search = 3\n", + "Looking for paths with length: 1 for node EHF and ETV4\n", + "i_search = 3\n", + "Looking for paths with length: 2 for node EHF and ETV4\n", + "i_search = 3\n", + "Looking for paths with length: 3 for node EHF and ETV4\n", + "looking for paths in the network with length: 0 for node EHF and ETV5\n", + "looking for paths in the network with length: 1 for node EHF and ETV5\n", + "looking for paths in the network with length: 2 for node EHF and ETV5\n", + "looking for paths in the network with length: 3 for node EHF and ETV5\n", + "looking for paths in the network with length: 4 for node EHF and ETV5\n", + "looking for paths in the network with length: 5 for node EHF and ETV5\n", + "looking for paths in the network with length: 6 for node EHF and ETV5\n", + "i_search = 3\n", + "Looking for paths with length: 0 for node EHF and ETV5\n", + "i_search = 3\n", + "Looking for paths with length: 1 for node EHF and ETV5\n", + "i_search = 3\n", + "Looking for paths with length: 2 for node EHF and ETV5\n", + "i_search = 3\n", + "Looking for paths with length: 3 for node EHF and ETV5\n", + "looking for paths in the network with length: 0 for node EHF and POU3F1\n", + "looking for paths in the network with length: 1 for node EHF and POU3F1\n", + "looking for paths in the network with length: 2 for node EHF and POU3F1\n", + "looking for paths in the network with length: 3 for node EHF and POU3F1\n", + "looking for paths in the network with length: 4 for node EHF and POU3F1\n", + "looking for paths in the network with length: 5 for node EHF and POU3F1\n", + "looking for paths in the network with length: 6 for node EHF and POU3F1\n", + "i_search = 3\n", + "Looking for paths with length: 0 for node EHF and POU3F1\n", + "i_search = 3\n", + "Looking for paths with length: 1 for node EHF and POU3F1\n", + "i_search = 3\n", + "Looking for paths with length: 2 for node EHF and POU3F1\n", + "i_search = 3\n", + "Looking for paths with length: 3 for node EHF and POU3F1\n", + "looking for paths in the network with length: 0 for node EHF and CEBPB\n", + "looking for paths in the network with length: 1 for node EHF and CEBPB\n", + "looking for paths in the network with length: 2 for node EHF and CEBPB\n", + "looking for paths in the network with length: 3 for node EHF and CEBPB\n", + "looking for paths in the network with length: 4 for node EHF and CEBPB\n", + "looking for paths in the network with length: 5 for node EHF and CEBPB\n", + "looking for paths in the network with length: 6 for node EHF and CEBPB\n", + "i_search = 3\n", + "Looking for paths with length: 0 for node EHF and CEBPB\n", + "i_search = 3\n", + "Looking for paths with length: 1 for node EHF and CEBPB\n", + "i_search = 3\n", + "Looking for paths with length: 2 for node EHF and CEBPB\n", + "i_search = 3\n", + "Looking for paths with length: 3 for node EHF and CEBPB\n", + "looking for paths in the network with length: 0 for node KLF5 and HOXA9\n", + "looking for paths in the network with length: 1 for node KLF5 and HOXA9\n", + "looking for paths in the network with length: 2 for node KLF5 and HOXA9\n", + "looking for paths in the network with length: 3 for node KLF5 and HOXA9\n", + "looking for paths in the network with length: 4 for node KLF5 and HOXA9\n", + "looking for paths in the network with length: 5 for node KLF5 and HOXA9\n", + "looking for paths in the network with length: 6 for node KLF5 and HOXA9\n", + "i_search = 3\n", + "Looking for paths with length: 0 for node KLF5 and HOXA9\n", + "i_search = 3\n", + "Looking for paths with length: 1 for node KLF5 and HOXA9\n", + "i_search = 3\n", + "Looking for paths with length: 2 for node KLF5 and HOXA9\n", + "i_search = 3\n", + "Looking for paths with length: 3 for node KLF5 and HOXA9\n", + "looking for paths in the network with length: 0 for node KLF5 and HOXA10\n", + "looking for paths in the network with length: 1 for node KLF5 and HOXA10\n", + "looking for paths in the network with length: 2 for node KLF5 and HOXA10\n", + "looking for paths in the network with length: 3 for node KLF5 and HOXA10\n", + "looking for paths in the network with length: 4 for node KLF5 and HOXA10\n", + "looking for paths in the network with length: 5 for node KLF5 and HOXA10\n", + "looking for paths in the network with length: 6 for node KLF5 and HOXA10\n", + "i_search = 3\n", + "Looking for paths with length: 0 for node KLF5 and HOXA10\n", + "i_search = 3\n", + "Looking for paths with length: 1 for node KLF5 and HOXA10\n", + "i_search = 3\n", + "Looking for paths with length: 2 for node KLF5 and HOXA10\n", + "i_search = 3\n", + "Looking for paths with length: 3 for node KLF5 and HOXA10\n", + "looking for paths in the network with length: 0 for node KLF5 and ETV4\n", + "looking for paths in the network with length: 1 for node KLF5 and ETV4\n", + "looking for paths in the network with length: 2 for node KLF5 and ETV4\n", + "looking for paths in the network with length: 3 for node KLF5 and ETV4\n", + "looking for paths in the network with length: 4 for node KLF5 and ETV4\n", + "looking for paths in the network with length: 5 for node KLF5 and ETV4\n", + "looking for paths in the network with length: 6 for node KLF5 and ETV4\n", + "i_search = 3\n", + "Looking for paths with length: 0 for node KLF5 and ETV4\n", + "i_search = 3\n", + "Looking for paths with length: 1 for node KLF5 and ETV4\n", + "i_search = 3\n", + "Looking for paths with length: 2 for node KLF5 and ETV4\n", + "i_search = 3\n", + "Looking for paths with length: 3 for node KLF5 and ETV4\n", + "looking for paths in the network with length: 0 for node KLF5 and ETV5\n", + "looking for paths in the network with length: 1 for node KLF5 and ETV5\n", + "looking for paths in the network with length: 2 for node KLF5 and ETV5\n", + "looking for paths in the network with length: 3 for node KLF5 and ETV5\n", + "looking for paths in the network with length: 4 for node KLF5 and ETV5\n", + "looking for paths in the network with length: 5 for node KLF5 and ETV5\n", + "looking for paths in the network with length: 6 for node KLF5 and ETV5\n", + "i_search = 3\n", + "Looking for paths with length: 0 for node KLF5 and ETV5\n", + "i_search = 3\n", + "Looking for paths with length: 1 for node KLF5 and ETV5\n", + "i_search = 3\n", + "Looking for paths with length: 2 for node KLF5 and ETV5\n", + "i_search = 3\n", + "Looking for paths with length: 3 for node KLF5 and ETV5\n", + "looking for paths in the network with length: 0 for node KLF5 and POU3F1\n", + "looking for paths in the network with length: 1 for node KLF5 and POU3F1\n", + "looking for paths in the network with length: 2 for node KLF5 and POU3F1\n", + "looking for paths in the network with length: 3 for node KLF5 and POU3F1\n", + "looking for paths in the network with length: 4 for node KLF5 and POU3F1\n", + "looking for paths in the network with length: 5 for node KLF5 and POU3F1\n", + "looking for paths in the network with length: 6 for node KLF5 and POU3F1\n", + "i_search = 3\n", + "Looking for paths with length: 0 for node KLF5 and POU3F1\n", + "i_search = 3\n", + "Looking for paths with length: 1 for node KLF5 and POU3F1\n", + "i_search = 3\n", + "Looking for paths with length: 2 for node KLF5 and POU3F1\n", + "i_search = 3\n", + "Looking for paths with length: 3 for node KLF5 and POU3F1\n", + "looking for paths in the network with length: 0 for node KLF5 and CEBPB\n", + "looking for paths in the network with length: 1 for node KLF5 and CEBPB\n", + "Found a path!\n", + "[['KLF5', 'CEBPB']]\n", + "looking for paths in the network with length: 0 for node HOXA9 and HOXA10\n", + "looking for paths in the network with length: 1 for node HOXA9 and HOXA10\n", + "looking for paths in the network with length: 2 for node HOXA9 and HOXA10\n", + "looking for paths in the network with length: 3 for node HOXA9 and HOXA10\n", + "looking for paths in the network with length: 4 for node HOXA9 and HOXA10\n", + "looking for paths in the network with length: 5 for node HOXA9 and HOXA10\n", + "looking for paths in the network with length: 6 for node HOXA9 and HOXA10\n", + "i_search = 3\n", + "Looking for paths with length: 0 for node HOXA9 and HOXA10\n", + "i_search = 3\n", + "Looking for paths with length: 1 for node HOXA9 and HOXA10\n", + "i_search = 3\n", + "Looking for paths with length: 2 for node HOXA9 and HOXA10\n", + "i_search = 3\n", + "Looking for paths with length: 3 for node HOXA9 and HOXA10\n", + "looking for paths in the network with length: 0 for node HOXA9 and ETV4\n", + "looking for paths in the network with length: 1 for node HOXA9 and ETV4\n", + "looking for paths in the network with length: 2 for node HOXA9 and ETV4\n", + "looking for paths in the network with length: 3 for node HOXA9 and ETV4\n", + "looking for paths in the network with length: 4 for node HOXA9 and ETV4\n", + "looking for paths in the network with length: 5 for node HOXA9 and ETV4\n", + "looking for paths in the network with length: 6 for node HOXA9 and ETV4\n", + "i_search = 3\n", + "Looking for paths with length: 0 for node HOXA9 and ETV4\n", + "i_search = 3\n", + "Looking for paths with length: 1 for node HOXA9 and ETV4\n", + "i_search = 3\n", + "Looking for paths with length: 2 for node HOXA9 and ETV4\n", + "i_search = 3\n", + "Looking for paths with length: 3 for node HOXA9 and ETV4\n", + "looking for paths in the network with length: 0 for node HOXA9 and ETV5\n", + "looking for paths in the network with length: 1 for node HOXA9 and ETV5\n", + "looking for paths in the network with length: 2 for node HOXA9 and ETV5\n", + "looking for paths in the network with length: 3 for node HOXA9 and ETV5\n", + "looking for paths in the network with length: 4 for node HOXA9 and ETV5\n", + "looking for paths in the network with length: 5 for node HOXA9 and ETV5\n", + "looking for paths in the network with length: 6 for node HOXA9 and ETV5\n", + "i_search = 3\n", + "Looking for paths with length: 0 for node HOXA9 and ETV5\n", + "i_search = 3\n", + "Looking for paths with length: 1 for node HOXA9 and ETV5\n", + "i_search = 3\n", + "Looking for paths with length: 2 for node HOXA9 and ETV5\n", + "i_search = 3\n", + "Looking for paths with length: 3 for node HOXA9 and ETV5\n", + "looking for paths in the network with length: 0 for node HOXA9 and POU3F1\n", + "looking for paths in the network with length: 1 for node HOXA9 and POU3F1\n", + "looking for paths in the network with length: 2 for node HOXA9 and POU3F1\n", + "looking for paths in the network with length: 3 for node HOXA9 and POU3F1\n", + "looking for paths in the network with length: 4 for node HOXA9 and POU3F1\n", + "looking for paths in the network with length: 5 for node HOXA9 and POU3F1\n", + "looking for paths in the network with length: 6 for node HOXA9 and POU3F1\n", + "i_search = 3\n", + "Looking for paths with length: 0 for node HOXA9 and POU3F1\n", + "i_search = 3\n", + "Looking for paths with length: 1 for node HOXA9 and POU3F1\n", + "i_search = 3\n", + "Looking for paths with length: 2 for node HOXA9 and POU3F1\n", + "i_search = 3\n", + "Looking for paths with length: 3 for node HOXA9 and POU3F1\n", + "looking for paths in the network with length: 0 for node HOXA9 and CEBPB\n", + "looking for paths in the network with length: 1 for node HOXA9 and CEBPB\n", + "looking for paths in the network with length: 2 for node HOXA9 and CEBPB\n", + "looking for paths in the network with length: 3 for node HOXA9 and CEBPB\n", + "looking for paths in the network with length: 4 for node HOXA9 and CEBPB\n", + "looking for paths in the network with length: 5 for node HOXA9 and CEBPB\n", + "looking for paths in the network with length: 6 for node HOXA9 and CEBPB\n", + "i_search = 3\n", + "Looking for paths with length: 0 for node HOXA9 and CEBPB\n", + "i_search = 3\n", + "Looking for paths with length: 1 for node HOXA9 and CEBPB\n", + "i_search = 3\n", + "Looking for paths with length: 2 for node HOXA9 and CEBPB\n", + "i_search = 3\n", + "Looking for paths with length: 3 for node HOXA9 and CEBPB\n", + "[['HOXA9', 'PIM1', 'FLT3', 'CEBPB']]\n", + "P31269 P11309\n", + "P11309 P36888\n", + "P36888 P17676\n", + "P55317 P0DMV8\n", + "P55317 P10275\n", + "P55317 O00712\n", + "P17676 Q13887\n", + "P04150 Q13887\n", + "Q15910 P31269\n", + "P31269 P11309\n", + "Q15910 P31260\n", + "O00712 P41161\n", + "P04150 P17676\n", + "P36888 P17676\n", + "P0DMV8 P04150\n", + "P04150 P10275\n", + "P10275 P04150\n", + "Q15910 P10275\n", + "O00712 Q15910\n", + "P11309 P36888\n", + "P36888 P11309\n", + "looking for paths in the network with length: 0 for node HOXA10 and ETV4\n", + "looking for paths in the network with length: 1 for node HOXA10 and ETV4\n", + "looking for paths in the network with length: 2 for node HOXA10 and ETV4\n", + "looking for paths in the network with length: 3 for node HOXA10 and ETV4\n", + "looking for paths in the network with length: 4 for node HOXA10 and ETV4\n", + "looking for paths in the network with length: 5 for node HOXA10 and ETV4\n", + "looking for paths in the network with length: 6 for node HOXA10 and ETV4\n", + "i_search = 3\n", + "Looking for paths with length: 0 for node HOXA10 and ETV4\n", + "i_search = 3\n", + "Looking for paths with length: 1 for node HOXA10 and ETV4\n", + "i_search = 3\n", + "Looking for paths with length: 2 for node HOXA10 and ETV4\n", + "i_search = 3\n", + "Looking for paths with length: 3 for node HOXA10 and ETV4\n", + "looking for paths in the network with length: 0 for node HOXA10 and ETV5\n", + "looking for paths in the network with length: 1 for node HOXA10 and ETV5\n", + "looking for paths in the network with length: 2 for node HOXA10 and ETV5\n", + "looking for paths in the network with length: 3 for node HOXA10 and ETV5\n", + "looking for paths in the network with length: 4 for node HOXA10 and ETV5\n", + "looking for paths in the network with length: 5 for node HOXA10 and ETV5\n", + "looking for paths in the network with length: 6 for node HOXA10 and ETV5\n", + "i_search = 3\n", + "Looking for paths with length: 0 for node HOXA10 and ETV5\n", + "i_search = 3\n", + "Looking for paths with length: 1 for node HOXA10 and ETV5\n", + "i_search = 3\n", + "Looking for paths with length: 2 for node HOXA10 and ETV5\n", + "i_search = 3\n", + "Looking for paths with length: 3 for node HOXA10 and ETV5\n", + "looking for paths in the network with length: 0 for node HOXA10 and POU3F1\n", + "looking for paths in the network with length: 1 for node HOXA10 and POU3F1\n", + "looking for paths in the network with length: 2 for node HOXA10 and POU3F1\n", + "looking for paths in the network with length: 3 for node HOXA10 and POU3F1\n", + "looking for paths in the network with length: 4 for node HOXA10 and POU3F1\n", + "looking for paths in the network with length: 5 for node HOXA10 and POU3F1\n", + "looking for paths in the network with length: 6 for node HOXA10 and POU3F1\n", + "i_search = 3\n", + "Looking for paths with length: 0 for node HOXA10 and POU3F1\n", + "i_search = 3\n", + "Looking for paths with length: 1 for node HOXA10 and POU3F1\n", + "i_search = 3\n", + "Looking for paths with length: 2 for node HOXA10 and POU3F1\n", + "i_search = 3\n", + "Looking for paths with length: 3 for node HOXA10 and POU3F1\n", + "looking for paths in the network with length: 0 for node HOXA10 and CEBPB\n", + "looking for paths in the network with length: 1 for node HOXA10 and CEBPB\n", + "looking for paths in the network with length: 2 for node HOXA10 and CEBPB\n", + "looking for paths in the network with length: 3 for node HOXA10 and CEBPB\n", + "looking for paths in the network with length: 4 for node HOXA10 and CEBPB\n", + "looking for paths in the network with length: 5 for node HOXA10 and CEBPB\n", + "looking for paths in the network with length: 6 for node HOXA10 and CEBPB\n", + "i_search = 3\n", + "Looking for paths with length: 0 for node HOXA10 and CEBPB\n", + "i_search = 3\n", + "Looking for paths with length: 1 for node HOXA10 and CEBPB\n", + "i_search = 3\n", + "Looking for paths with length: 2 for node HOXA10 and CEBPB\n", + "i_search = 3\n", + "Looking for paths with length: 3 for node HOXA10 and CEBPB\n", + "looking for paths in the network with length: 0 for node ETV4 and ETV5\n", + "looking for paths in the network with length: 1 for node ETV4 and ETV5\n", + "looking for paths in the network with length: 2 for node ETV4 and ETV5\n", + "looking for paths in the network with length: 3 for node ETV4 and ETV5\n", + "looking for paths in the network with length: 4 for node ETV4 and ETV5\n", + "looking for paths in the network with length: 5 for node ETV4 and ETV5\n", + "looking for paths in the network with length: 6 for node ETV4 and ETV5\n", + "i_search = 3\n", + "Looking for paths with length: 0 for node ETV4 and ETV5\n", + "i_search = 3\n", + "Looking for paths with length: 1 for node ETV4 and ETV5\n", + "i_search = 3\n", + "Looking for paths with length: 2 for node ETV4 and ETV5\n", + "i_search = 3\n", + "Looking for paths with length: 3 for node ETV4 and ETV5\n", + "looking for paths in the network with length: 0 for node ETV4 and POU3F1\n", + "looking for paths in the network with length: 1 for node ETV4 and POU3F1\n", + "looking for paths in the network with length: 2 for node ETV4 and POU3F1\n", + "looking for paths in the network with length: 3 for node ETV4 and POU3F1\n", + "looking for paths in the network with length: 4 for node ETV4 and POU3F1\n", + "looking for paths in the network with length: 5 for node ETV4 and POU3F1\n", + "looking for paths in the network with length: 6 for node ETV4 and POU3F1\n", + "i_search = 3\n", + "Looking for paths with length: 0 for node ETV4 and POU3F1\n", + "i_search = 3\n", + "Looking for paths with length: 1 for node ETV4 and POU3F1\n", + "i_search = 3\n", + "Looking for paths with length: 2 for node ETV4 and POU3F1\n", + "i_search = 3\n", + "Looking for paths with length: 3 for node ETV4 and POU3F1\n", + "looking for paths in the network with length: 0 for node ETV4 and CEBPB\n", + "looking for paths in the network with length: 1 for node ETV4 and CEBPB\n", + "looking for paths in the network with length: 2 for node ETV4 and CEBPB\n", + "looking for paths in the network with length: 3 for node ETV4 and CEBPB\n", + "looking for paths in the network with length: 4 for node ETV4 and CEBPB\n", + "looking for paths in the network with length: 5 for node ETV4 and CEBPB\n", + "looking for paths in the network with length: 6 for node ETV4 and CEBPB\n", + "i_search = 3\n", + "Looking for paths with length: 0 for node ETV4 and CEBPB\n", + "i_search = 3\n", + "Looking for paths with length: 1 for node ETV4 and CEBPB\n", + "i_search = 3\n", + "Looking for paths with length: 2 for node ETV4 and CEBPB\n", + "i_search = 3\n", + "Looking for paths with length: 3 for node ETV4 and CEBPB\n", + "looking for paths in the network with length: 0 for node ETV5 and POU3F1\n", + "looking for paths in the network with length: 1 for node ETV5 and POU3F1\n", + "looking for paths in the network with length: 2 for node ETV5 and POU3F1\n", + "looking for paths in the network with length: 3 for node ETV5 and POU3F1\n", + "looking for paths in the network with length: 4 for node ETV5 and POU3F1\n", + "looking for paths in the network with length: 5 for node ETV5 and POU3F1\n", + "looking for paths in the network with length: 6 for node ETV5 and POU3F1\n", + "i_search = 3\n", + "Looking for paths with length: 0 for node ETV5 and POU3F1\n", + "i_search = 3\n", + "Looking for paths with length: 1 for node ETV5 and POU3F1\n", + "i_search = 3\n", + "Looking for paths with length: 2 for node ETV5 and POU3F1\n", + "i_search = 3\n", + "Looking for paths with length: 3 for node ETV5 and POU3F1\n", + "looking for paths in the network with length: 0 for node ETV5 and CEBPB\n", + "looking for paths in the network with length: 1 for node ETV5 and CEBPB\n", + "looking for paths in the network with length: 2 for node ETV5 and CEBPB\n", + "looking for paths in the network with length: 3 for node ETV5 and CEBPB\n", + "looking for paths in the network with length: 4 for node ETV5 and CEBPB\n", + "looking for paths in the network with length: 5 for node ETV5 and CEBPB\n", + "looking for paths in the network with length: 6 for node ETV5 and CEBPB\n", + "i_search = 3\n", + "Looking for paths with length: 0 for node ETV5 and CEBPB\n", + "i_search = 3\n", + "Looking for paths with length: 1 for node ETV5 and CEBPB\n", + "i_search = 3\n", + "Looking for paths with length: 2 for node ETV5 and CEBPB\n", + "i_search = 3\n", + "Looking for paths with length: 3 for node ETV5 and CEBPB\n", + "looking for paths in the network with length: 0 for node POU3F1 and CEBPB\n", + "looking for paths in the network with length: 1 for node POU3F1 and CEBPB\n", + "looking for paths in the network with length: 2 for node POU3F1 and CEBPB\n", + "looking for paths in the network with length: 3 for node POU3F1 and CEBPB\n", + "looking for paths in the network with length: 4 for node POU3F1 and CEBPB\n", + "looking for paths in the network with length: 5 for node POU3F1 and CEBPB\n", + "looking for paths in the network with length: 6 for node POU3F1 and CEBPB\n", + "i_search = 3\n", + "Looking for paths with length: 0 for node POU3F1 and CEBPB\n", + "i_search = 3\n", + "Looking for paths with length: 1 for node POU3F1 and CEBPB\n", + "i_search = 3\n", + "Looking for paths with length: 2 for node POU3F1 and CEBPB\n", + "i_search = 3\n", + "Looking for paths with length: 3 for node POU3F1 and CEBPB\n", + "CPU times: user 8.91 s, sys: 36 ms, total: 8.95 s\n", + "Wall time: 8.91 s\n" + ] + } + ], + "source": [ + "%%time\n", + "new_net1.complete_connection(mode=\"ALL\", maxlen=6, k_mean=\"tight\", only_signed=True,\n", + " connect_node_when_first_introduced=True) # here, consensus_only is missing, in this way it is automatically False" + ] + }, + { + "cell_type": "markdown", + "id": "64b445e7-2e45-40ee-9ee9-268965b4d55b", + "metadata": {}, + "source": [ + "## SIGNOR uses has different identifiers for complexes, protein family, phenotype, etc.\n", + "## It is possible that the network contains nodes names like \"Signor_pf32\" or something like this... This is not yet translated, but if you are interested in what those nodes consist of, you can use download their vocabulary for the entities: https://signor.uniroma2.it/downloads.php\n", + "## Maybe we are going to integrate this too... " + ] + }, + { + "cell_type": "markdown", + "id": "6b54c437", + "metadata": {}, + "source": [ + "### Finally we can export the network in bnet format with some basic logical equations or in sif format for Cytoscape visualization" + ] + }, + { + "cell_type": "code", + "execution_count": 13, + "id": "547e4090", + "metadata": {}, + "outputs": [], + "source": [ + "from omniflow_project._outputs.exports import Exports" + ] + }, + { + "cell_type": "code", + "execution_count": 14, + "id": "6fd81835", + "metadata": {}, + "outputs": [], + "source": [ + "export = Exports(new_net1)" + ] + }, + { + "cell_type": "code", + "execution_count": 15, + "id": "a408094f", + "metadata": {}, + "outputs": [], + "source": [ + "export.export_bnet()\n", + "export.export_sif()" + ] + }, + { + "cell_type": "markdown", + "id": "8ed135d3-9f71-4cec-9381-96c63fba766e", + "metadata": {}, + "source": [ + "### Gene Ontology\n", + "## A new feature of Omniflow. Now, the user can connect the nodes of the Network with markers of a certain phenotype, from Gene Ontology. " + ] + }, + { + "cell_type": "code", + "execution_count": 10, + "id": "fa499a38-c22a-4a0e-b1d4-3ffb10e4a370", + "metadata": {}, + "outputs": [ + { + "name": "stdout", + "output_type": "stream", + "text": [ + "Start requesting genes from Gene Ontology\n", + "Fetching from: https://golr-aux.geneontology.io/solr/select?defType=edismax&qt=standard&indent=on&wt=csv&rows=100000&start=0&fl=bioentity_label&facet=true&facet.mincount=1&facet.sort=count&json.nl=arrarr&facet.limit=25&hl=true&hl.simple.pre=%3Cem%20class=%22hilite%22%3E&hl.snippets=1000&csv.encapsulator=&csv.separator=%09&csv.header=false&csv.mv.separator=%7C&fq=document_category:%22annotation%22&fq=isa_partof_closure:%22GO:0097194%22&fq=taxon_subset_closure_label:%22Homo%20sapiens%22&fq=type:%22protein%22&fq=annotation_class_label:%22execution%20phase%20of%20apoptosis%22&facet.field=aspect&facet.field=taxon_subset_closure_label&facet.field=type&facet.field=evidence_subset_closure_label&facet.field=regulates_closure_label&facet.field=isa_partof_closure_label&facet.field=annotation_class_label&facet.field=qualifier&facet.field=annotation_extension_class_closure_label&facet.field=assigned_by&facet.field=panther_family_label&q=*:*\n", + "Done\n", + "Starting connecting network's nodes to: ['AIFM3', 'CASP7', 'MADD', 'CASP3', 'CASP8', 'CASP5', 'BNIP1', 'CIDEC', 'COLEC11', 'HTRA2', 'CASP12', 'TAOK1', 'BBC3', 'CFLAR', 'CIDEB', 'NFKBIZ', 'CASP6', 'STK24', 'CASP4', 'AKT1', 'NPR2', 'CASP2', 'CECR2']\n", + "Q01094 Q96PG8\n", + "P28482 Q14790\n", + "P31749 O15519\n", + "P31749 O43464\n", + "P06493 Q14790\n", + "P62136 P42575\n", + "SIGNOR-PF54 P42575\n", + "Q13315 Q7L7X3\n", + "P68400 P42575\n", + "Q16539 O15519\n", + "Q16539 P42574\n", + "Q16539 Q14790\n", + "P27361 Q14790\n", + "SIGNOR-PF1 Q14790\n", + "CPU times: user 1.17 s, sys: 1.02 ms, total: 1.17 s\n", + "Wall time: 1.98 s\n" + ] + } + ], + "source": [ + "%%time\n", + "new_net1.connect_genes_to_phenotype(id_accession=\"GO:0097194\", phenotype=\"execution phase of apoptosis\", only_signed=True, compress=True, maxlen=1)" + ] + }, + { + "cell_type": "markdown", + "id": "48bf53a4", + "metadata": {}, + "source": [ + "# TO DO:\n", + "\n", + "- method to print sif file with reference for each interaction (easy task)\n", + "- more utility functions (???)\n", + "- create function to look for common upstream for group of nodes" + ] + }, + { + "cell_type": "code", + "execution_count": null, + "id": "33300268-bcf6-442b-97be-c7718922a939", + "metadata": {}, + "outputs": [], + "source": [] + } + ], + "metadata": { + "kernelspec": { + "display_name": "Python 3 (ipykernel)", + "language": "python", + "name": "python3" + }, + "language_info": { + "codemirror_mode": { + "name": "ipython", + "version": 3 + }, + "file_extension": ".py", + "mimetype": "text/x-python", + "name": "python", + "nbconvert_exporter": "python", + "pygments_lexer": "ipython3", + "version": "3.10.13" + } + }, + "nbformat": 4, + "nbformat_minor": 5 +} diff --git a/notebooks/.ipynb_checkpoints/build_phosphosite_network-checkpoint.ipynb b/notebooks/.ipynb_checkpoints/build_phosphosite_network-checkpoint.ipynb new file mode 100644 index 0000000..f01a1d9 --- /dev/null +++ b/notebooks/.ipynb_checkpoints/build_phosphosite_network-checkpoint.ipynb @@ -0,0 +1,441 @@ +{ + "cells": [ + { + "cell_type": "markdown", + "id": "4feb78a3-acc2-455c-b206-c37b7ea47932", + "metadata": {}, + "source": [ + "## Build phosphoste network\n", + "\n", + "This notebook provides the code to create a network based on kinase-substrate interactions and the annotated effect of phosphorylation (based on PhosphositePlus) on the activity of the substrate." + ] + }, + { + "cell_type": "code", + "execution_count": 4, + "id": "3c317de8", + "metadata": {}, + "outputs": [ + { + "name": "stdout", + "output_type": "stream", + "text": [ + "CPU times: user 14 µs, sys: 2 µs, total: 16 µs\n", + "Wall time: 20 µs\n" + ] + } + ], + "source": [ + "%%time\n", + "from omniflow_project.core.network import Network\n", + "from omniflow_project._visual.visualize_network import NetworkVisualizer\n", + "from omniflow_project._inputs.resources import Resources\n", + "#from omniflow_project._annotations.gene_ontology import Ontology\n", + "import omnipath as op\n", + "import pandas as pd" + ] + }, + { + "cell_type": "markdown", + "id": "e41d36f1-b603-4d04-bea5-972c03764c92", + "metadata": {}, + "source": [ + "## 1. Specify kinase-substrate interaction file and phosphosite effect annotation\n", + "\n", + "In this example, both files we utilize are from PhosphositePlus." + ] + }, + { + "cell_type": "code", + "execution_count": 23, + "id": "17d662bc-dc7f-4597-9a42-d9da7bdd1ed3", + "metadata": {}, + "outputs": [], + "source": [ + "kinase_int_file = (\"/home/eirini/Documents/Git/omniflow_project/Kinase_Substrate_Dataset\")\n", + "phospho_effect_file = (\"/home/eirini/Documents/Git/omniflow_project/Regulatory_sites\")" + ] + }, + { + "cell_type": "markdown", + "id": "d0fd3a1c-8419-4aa7-a7bd-30f92df14c69", + "metadata": {}, + "source": [ + "## 2. Add interactions as a resource database\n", + "\n", + "The *_process_psp_interactions_* function parses the provided files to create an interaction database in the Omnipath format." + ] + }, + { + "cell_type": "code", + "execution_count": 36, + "id": "4d4cfe2f-fe7c-4764-9100-9543ac1a9a1b", + "metadata": {}, + "outputs": [ + { + "name": "stderr", + "output_type": "stream", + "text": [ + "/tmp/ipykernel_41274/4112765230.py:12: SettingWithCopyWarning: \n", + "A value is trying to be set on a copy of a slice from a DataFrame.\n", + "Try using .loc[row_indexer,col_indexer] = value instead\n", + "\n", + "See the caveats in the documentation: https://pandas.pydata.org/pandas-docs/stable/user_guide/indexing.html#returning-a-view-versus-a-copy\n", + " kinase_int_filtered['target'] = kinase_int_filtered['SUB_GENE'] + '_' + kinase_int_filtered['SUB_MOD_RSD']\n", + "/tmp/ipykernel_41274/4112765230.py:28: SettingWithCopyWarning: \n", + "A value is trying to be set on a copy of a slice from a DataFrame.\n", + "Try using .loc[row_indexer,col_indexer] = value instead\n", + "\n", + "See the caveats in the documentation: https://pandas.pydata.org/pandas-docs/stable/user_guide/indexing.html#returning-a-view-versus-a-copy\n", + " phospho_effect_filtered['MOD_RSD'] = phospho_effect_filtered['MOD_RSD'].apply(lambda x: x[:-2] if x.endswith('-p') else x)\n", + "/tmp/ipykernel_41274/4112765230.py:31: SettingWithCopyWarning: \n", + "A value is trying to be set on a copy of a slice from a DataFrame.\n", + "Try using .loc[row_indexer,col_indexer] = value instead\n", + "\n", + "See the caveats in the documentation: https://pandas.pydata.org/pandas-docs/stable/user_guide/indexing.html#returning-a-view-versus-a-copy\n", + " phospho_effect_filtered['Prot_site'] = phospho_effect_filtered['GENE'] + '_' + phospho_effect_filtered['MOD_RSD']\n" + ] + } + ], + "source": [ + "interactions = process_psp_interactions(kinase_int_file, phospho_effect_file, \"rat\", expand=True)\n", + "resources.add_database(interactions)" + ] + }, + { + "cell_type": "code", + "execution_count": 37, + "id": "9bc52933-3fb6-4b91-af67-454cc5891e98", + "metadata": {}, + "outputs": [ + { + "data": { + "text/html": [ + "
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0Pak2Map2k1_S298TrueFalseFalseFalse10NaNNaNNaN
3IkbkbNfkbia_S32TrueFalseFalseFalse10NaNNaNNaN
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....................................
1943Atp1a1_S16Atp1a1TrueFalseFalseFalse11FalseFalseFalse
1944Atp1a1_S23Atp1a1TrueFalseFalseFalse11FalseFalseFalse
1946Akt1_T34Akt1TrueFalseFalseFalse01FalseFalseFalse
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1951Mark2_T208Mark2TrueFalseFalseFalse10FalseFalseFalse
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664 rows × 11 columns

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" + ], + "text/plain": [ + " source target is_directed consensus_direction \\\n", + "0 Pak2 Map2k1_S298 True False \n", + "3 Ikbkb Nfkbia_S32 True False \n", + "5 Ikbkb Nfkbia_S36 True False \n", + "8 Mapk8 Dlg4_S295 True False \n", + "9 Mapk8 Nr3c1_S246 True False \n", + "... ... ... ... ... \n", + "1943 Atp1a1_S16 Atp1a1 True False \n", + "1944 Atp1a1_S23 Atp1a1 True False \n", + "1946 Akt1_T34 Akt1 True False \n", + "1947 Pebp1_S153 Pebp1 True False \n", + "1951 Mark2_T208 Mark2 True False \n", + "\n", + " consensus_stimulation consensus_inhibition is_stimulation \\\n", + "0 False False 1 \n", + "3 False False 1 \n", + "5 False False 1 \n", + "8 False False 1 \n", + "9 False False 1 \n", + "... ... ... ... \n", + "1943 False False 1 \n", + "1944 False False 1 \n", + "1946 False False 0 \n", + "1947 False False 1 \n", + "1951 False False 1 \n", + "\n", + " is_inhibition curation_effort references sources \n", + "0 0 NaN NaN NaN \n", + "3 0 NaN NaN NaN \n", + "5 0 NaN NaN NaN \n", + "8 0 NaN NaN NaN \n", + "9 1 NaN NaN NaN \n", + "... ... ... ... ... \n", + "1943 1 False False False \n", + "1944 1 False False False \n", + "1946 1 False False False \n", + "1947 1 False False False \n", + "1951 0 False False False \n", + "\n", + "[664 rows x 11 columns]" + ] + }, + "execution_count": 37, + "metadata": {}, + "output_type": "execute_result" + } + ], + "source": [ + "#inspect database\n", + "interactions" + ] + }, + { + "cell_type": "markdown", + "id": "7fe1b7d5", + "metadata": {}, + "source": [ + "### 3. Define a set of phosphosites we are interested in" + ] + }, + { + "cell_type": "code", + "execution_count": null, + "id": "a3fea926-81f1-4826-b91c-3b04124de715", + "metadata": {}, + "outputs": [], + "source": [ + "genes = ['SMAD3_S423', 'SMAD3_S425', 'TP53_S15', 'AKT1S1_T246', 'GSK3B_S9', 'GSK3B_S21', 'AKT1_S473', 'HSPB1_S78', 'HSPB1_S82', 'MAPK14_T180', 'MAPK14_Y182', 'MAP2K1_S218', 'MAP2K1_S222', 'RPS6KA1_S380', 'CREB1_S133', 'NFKBIA_S32', 'NFKBIA_S36', 'MTOR_S2448', 'JUN_S63', 'EGFR_Y1068', 'MAPK3_T202', 'MAPK3_Y204', 'PTPN11_Y542', 'STAT3_Y705', 'CHEK2_T68', 'RELA_S536', 'MARCKS_S170']\n", + "\n", + "#genes = ['SMAD3_S423', 'SMAD3_S425', 'TP53_S15', 'AKT1S1_T246', 'GSK3B_S9', 'GSK3B_S21', 'AKT1_S473', 'HSPB1_S78']" + ] + }, + { + "cell_type": "markdown", + "id": "59d3c824-ad97-43ae-9bf4-6657e7bcf72f", + "metadata": {}, + "source": [ + "### 4. Build network" + ] + }, + { + "cell_type": "code", + "execution_count": null, + "id": "9c824c50", + "metadata": {}, + "outputs": [], + "source": [ + "%%time\n", + "new_net1 = Network(genes, resources=resources.interactions)" + ] + }, + { + "cell_type": "code", + "execution_count": null, + "id": "9a07d77b", + "metadata": {}, + "outputs": [], + "source": [ + "%%time\n", + "new_net1.complete_connection(mode=\"ALL\", maxlen=10, k_mean=\"extensive\", only_signed=True, connect_node_when_first_introduced=True)" + ] + }, + { + "cell_type": "code", + "execution_count": null, + "id": "152b9434", + "metadata": {}, + "outputs": [], + "source": [ + "visualizer1 = NetworkVisualizer(new_net1, color_by='effect')\n", + "visualizer1.render(output_file='inp_prot_sites')" + ] + } + ], + "metadata": { + "kernelspec": { + "display_name": "Python 3 (ipykernel)", + "language": "python", + "name": "python3" + }, + "language_info": { + "codemirror_mode": { + "name": "ipython", + "version": 3 + }, + "file_extension": ".py", + "mimetype": "text/x-python", + "name": "python", + "nbconvert_exporter": "python", + "pygments_lexer": "ipython3", + "version": "3.10.13" + } + }, + "nbformat": 4, + "nbformat_minor": 5 +} diff --git a/notebooks/.ipynb_checkpoints/network_building-checkpoint.ipynb b/notebooks/.ipynb_checkpoints/network_building-checkpoint.ipynb new file mode 100644 index 0000000..3d4f46d --- /dev/null +++ b/notebooks/.ipynb_checkpoints/network_building-checkpoint.ipynb @@ -0,0 +1,9918 @@ +{ + "cells": [ + { + "cell_type": "markdown", + "id": "55b5595c-fec9-41c3-b756-b95cd0c52048", + "metadata": {}, + "source": [ + "## Network building\n", + "\n", + "This notebook provides the steps to build a network starting from a list of genes, and using the default functionalities of Omniflow." + ] + }, + { + "cell_type": "code", + "execution_count": 2, + "id": "3c317de8", + "metadata": {}, + "outputs": [ + { + "name": "stderr", + "output_type": "stream", + "text": [ + "/home/eirini/anaconda3/envs/omniflow_env/lib/python3.10/site-packages/tqdm/auto.py:21: TqdmWarning: IProgress not found. Please update jupyter and ipywidgets. See https://ipywidgets.readthedocs.io/en/stable/user_install.html\n", + " from .autonotebook import tqdm as notebook_tqdm\n" + ] + }, + { + "ename": "ModuleNotFoundError", + "evalue": "No module named 'omniflow_project._annotations'", + "output_type": "error", + "traceback": [ + "\u001b[0;31m---------------------------------------------------------------------------\u001b[0m", + "\u001b[0;31mModuleNotFoundError\u001b[0m Traceback (most recent call last)", + "File \u001b[0;32m:4\u001b[0m\n", + "\u001b[0;31mModuleNotFoundError\u001b[0m: No module named 'omniflow_project._annotations'" + ] + } + ], + "source": [ + "%%time\n", + "from omniflow_project.core.network import Network\n", + "from omniflow_project._visual.visualize_network import NetworkVisualizer\n", + "from omniflow_project._inputs.resources import Resources\n", + "from omniflow_project._annotations.gene_ontology import Ontology\n", + "import omnipath as op" + ] + }, + { + "cell_type": "markdown", + "id": "7fe1b7d5", + "metadata": {}, + "source": [ + "### 1. Define the list of genes of interest" + ] + }, + { + "cell_type": "code", + "execution_count": 3, + "id": "79c09e13", + "metadata": {}, + "outputs": [], + "source": [ + "genes = [\"SRC\", \"NOTCH1\", \"FAK\", \"CDH1\", \"CDH2\", \"VIM\", \"MAP4K4\", \"LATS1\", \"LATS2\", \"PTK2B\"]" + ] + }, + { + "cell_type": "markdown", + "id": "6a5b5adf", + "metadata": {}, + "source": [ + "### 2. Create a network using as input the gene set. \n", + "\n", + "NB! If no resource is specified, the default used resource by the package is omnipath.all_interactions()" + ] + }, + { + "cell_type": "markdown", + "id": "2910c871-fdfc-4d20-b76f-af213f06a3f0", + "metadata": {}, + "source": [ + "#### 2A. Import genes as network nodes" + ] + }, + { + "cell_type": "code", + "execution_count": 3, + "id": "fcf68a99-8454-41e3-8816-c3f976d04c0b", + "metadata": {}, + "outputs": [ + { + "name": "stdout", + "output_type": "stream", + "text": [ + "Loading deafault omnipath all interactions\n" + ] + } + ], + "source": [ + "new_net1 = Network(genes)" + ] + }, + { + "cell_type": "code", + "execution_count": 4, + "id": "fad00bec-ba72-4943-bf1e-9c60f58f17a2", + "metadata": {}, + "outputs": [ + { + "ename": "NameError", + "evalue": "name 'new_net1' is not defined", + "output_type": "error", + "traceback": [ + "\u001b[0;31m---------------------------------------------------------------------------\u001b[0m", + "\u001b[0;31mNameError\u001b[0m Traceback (most recent call last)", + "Cell \u001b[0;32mIn[4], line 2\u001b[0m\n\u001b[1;32m 1\u001b[0m \u001b[38;5;66;03m#Print node dataframe\u001b[39;00m\n\u001b[0;32m----> 2\u001b[0m \u001b[43mnew_net1\u001b[49m\u001b[38;5;241m.\u001b[39mnodes\n", + "\u001b[0;31mNameError\u001b[0m: name 'new_net1' is not defined" + ] + } + ], + "source": [ + "#Print node dataframe\n", + "new_net1.nodes" + ] + }, + { + "cell_type": "markdown", + "id": "a2759581", + "metadata": {}, + "source": [ + "#### 2B. Explore if the nodes are connected without introducing new intermidiate nodes" + ] + }, + { + "cell_type": "code", + "execution_count": 5, + "id": "a339705b", + "metadata": {}, + "outputs": [ + { + "name": "stdout", + "output_type": "stream", + "text": [ + "P12931 Q05397\n", + "P12931 P19022\n", + "P12931 Q14289\n", + "Q14289 Q05397\n", + "CPU times: user 496 ms, sys: 0 ns, total: 496 ms\n", + "Wall time: 495 ms\n" + ] + } + ], + "source": [ + "%%time\n", + "new_net1.connect_nodes(only_signed=True, consensus_only=True)" + ] + }, + { + "cell_type": "markdown", + "id": "2fb5674d", + "metadata": {}, + "source": [ + "#### 2C. Visualize the network with the following command. \n", + "\n", + "The network picture is also exported in the working repository, in pdf format." + ] + }, + { + "cell_type": "code", + "execution_count": 7, + "id": "db39112a", + "metadata": {}, + "outputs": [ + { + "data": { + "image/svg+xml": [ + "\n", + "\n", + "\n", + "\n", + "\n", + "\n", + "%3\n", + "\n", + "\n", + "\n", + "SRC\n", + "\n", + "SRC\n", + "\n", + "\n", + "\n", + "PTK2\n", + "\n", + "PTK2\n", + "\n", + "\n", + "\n", + "SRC->PTK2\n", + "\n", + "\n", + "\n", + "\n", + "\n", + "CDH2\n", + "\n", + "CDH2\n", + "\n", + "\n", + "\n", + "SRC->CDH2\n", + "\n", + "\n", + "\n", + "\n", + "\n", + "\n", + "PTK2B\n", + "\n", + "PTK2B\n", + "\n", + "\n", + "\n", + "SRC->PTK2B\n", + "\n", + "\n", + "\n", + "\n", + "\n", + "PTK2B->PTK2\n", + "\n", + "\n", + "\n", + "\n", + "\n", + "NOTCH1\n", + "\n", + "NOTCH1\n", + "\n", + "\n", + "\n", + "CDH1\n", + "\n", + "CDH1\n", + "\n", + "\n", + "\n", + "VIM\n", + "\n", + "VIM\n", + "\n", + "\n", + "\n", + "MAP4K4\n", + "\n", + "MAP4K4\n", + "\n", + "\n", + "\n", + "LATS1\n", + "\n", + "LATS1\n", + "\n", + "\n", + "\n", + "LATS2\n", + "\n", + "LATS2\n", + "\n", + "\n", + "\n" + ], + "text/plain": [ + "" + ] + }, + "metadata": {}, + "output_type": "display_data" + } + ], + "source": [ + "visualizer = NetworkVisualizer(new_net1, color_by='effect')\n", + "visualizer.render(output_file=\"new_network\")" + ] + }, + { + "cell_type": "markdown", + "id": "3c1725cc-4c08-4a85-b26c-8f59936e351d", + "metadata": {}, + "source": [ + "#### 2D. Connect disconnected nodes by importing intermediate nodes.\n", + "\n", + "The parameter _*maxlen*_ is used to verify that in the network all the nodes have a distance < than maxlen. \n", + "\n", + "The parameter _*only_signed*_ forces the algorithm to look for just signed interactions. \n", + "\n", + "The parameter _*consensus*_ retrieves those interactions with a sign consensus between the references. \n", + "\n", + "The parameter _*connect_node_when_first_introduced*_, changes the base algorithm, making it look for possible connection between all the disconnected node in the network when a new bridge-gene is introduced in the network." + ] + }, + { + "cell_type": "code", + "execution_count": 8, + "id": "9a07d77b", + "metadata": {}, + "outputs": [ + { + "name": "stdout", + "output_type": "stream", + "text": [ + "looking for paths in the network with length: 0 for node SRC and NOTCH1\n", + "looking for paths in the network with length: 1 for node SRC and NOTCH1\n", + "looking for paths in the network with length: 2 for node SRC and NOTCH1\n", + "looking for paths in the network with length: 3 for node SRC and NOTCH1\n", + "looking for paths in the network with length: 4 for node SRC and NOTCH1\n", + "looking for paths in the network with length: 5 for node SRC and NOTCH1\n", + "looking for paths in the network with length: 6 for node SRC and NOTCH1\n", + "i_search = 3\n", + "Looking for paths with length: 0 for node SRC and NOTCH1\n", + "i_search = 3\n", + "Looking for paths with length: 1 for node SRC and NOTCH1\n", + "i_search = 3\n", + "Looking for paths with length: 2 for node SRC and NOTCH1\n", + "[['SRC', 'CTNNB1', 'NOTCH1'], ['SRC', 'DAB1', 'NOTCH1']]\n", + "P12931 P35222\n", + "P35222 P46531\n", + "P12931 O75553\n", + "O75553 P46531\n", + "P12931 Q05397\n", + "P12931 P19022\n", + "P12931 Q14289\n", + "P12931 P35222\n", + "P12931 O75553\n", + "P35222 P46531\n", + "O75553 P46531\n", + "Q14289 Q05397\n", + "P12830 P35222\n", + "P19022 P35222\n", + "looking for paths in the network with length: 0 for node SRC and PTK2\n", + "looking for paths in the network with length: 1 for node SRC and PTK2\n", + "Found a path!\n", + "[['SRC', 'PTK2']]\n", + "looking for paths in the network with length: 0 for node SRC and CDH1\n", + "looking for paths in the network with length: 1 for node SRC and CDH1\n", + "looking for paths in the network with length: 2 for node SRC and CDH1\n", + "looking for paths in the network with length: 3 for node SRC and CDH1\n", + "looking for paths in the network with length: 4 for node SRC and CDH1\n", + "looking for paths in the network with length: 5 for node SRC and CDH1\n", + "looking for paths in the network with length: 6 for node SRC and CDH1\n", + "i_search = 3\n", + "Looking for paths with length: 0 for node SRC and CDH1\n", + "i_search = 3\n", + "Looking for paths with length: 1 for node SRC and CDH1\n", + "i_search = 3\n", + "Looking for paths with length: 2 for node SRC and CDH1\n", + "[['SRC', 'MET', 'CDH1'], ['SRC', 'PRKD1', 'CDH1'], ['SRC', 'CTNND1', 'CDH1']]\n", + "P12931 P08581\n", + "P08581 P12830\n", + "P12931 Q15139\n", + "Q15139 P12830\n", + "P12931 O60716\n", + "O60716 P12830\n", + "P12931 Q05397\n", + "P12931 P19022\n", + "P12931 Q14289\n", + "P12931 P35222\n", + "P12931 O75553\n", + "P12931 P08581\n", + "P12931 Q15139\n", + "P12931 O60716\n", + "P35222 P46531\n", + "O75553 P46531\n", + "Q14289 Q05397\n", + "P08581 Q05397\n", + "P12830 P35222\n", + "P08581 P12830\n", + "Q15139 P12830\n", + "O60716 P12830\n", + "P19022 P35222\n", + "O60716 P19022\n", + "Q15139 P35222\n", + "looking for paths in the network with length: 0 for node SRC and CDH2\n", + "looking for paths in the network with length: 1 for node SRC and CDH2\n", + "Found a path!\n", + "[['SRC', 'CDH2']]\n", + "looking for paths in the network with length: 0 for node SRC and VIM\n", + "looking for paths in the network with length: 1 for node SRC and VIM\n", + "looking for paths in the network with length: 2 for node SRC and VIM\n", + "looking for paths in the network with length: 3 for node SRC and VIM\n", + "looking for paths in the network with length: 4 for node SRC and VIM\n", + "looking for paths in the network with length: 5 for node SRC and VIM\n", + "looking for paths in the network with length: 6 for node SRC and VIM\n", + "i_search = 3\n", + "Looking for paths with length: 0 for node SRC and VIM\n", + "i_search = 3\n", + "Looking for paths with length: 1 for node SRC and VIM\n", + "i_search = 3\n", + "Looking for paths with length: 2 for node SRC and VIM\n", + "[['SRC', 'PAK2', 'VIM']]\n", + "P12931 Q13177\n", + "Q13177 P08670\n", + "P12931 Q05397\n", + "P12931 P19022\n", + "P12931 Q14289\n", + "P12931 P35222\n", + "P12931 O75553\n", + "P12931 P08581\n", + "P12931 Q15139\n", + "P12931 O60716\n", + "P12931 Q13177\n", + "P35222 P46531\n", + "O75553 P46531\n", + "Q14289 Q05397\n", + "P08581 Q05397\n", + "P12830 P35222\n", + "P08581 P12830\n", + "Q15139 P12830\n", + "O60716 P12830\n", + "P19022 P35222\n", + "O60716 P19022\n", + "Q13177 P08670\n", + "Q15139 P35222\n", + "looking for paths in the network with length: 0 for node SRC and MAP4K4\n", + "looking for paths in the network with length: 1 for node SRC and MAP4K4\n", + "looking for paths in the network with length: 2 for node SRC and MAP4K4\n", + "looking for paths in the network with length: 3 for node SRC and MAP4K4\n", + "looking for paths in the network with length: 4 for node SRC and MAP4K4\n", + "looking for paths in the network with length: 5 for node SRC and MAP4K4\n", + "looking for paths in the network with length: 6 for node SRC and MAP4K4\n", + "i_search = 3\n", + "Looking for paths with length: 0 for node SRC and MAP4K4\n", + "i_search = 3\n", + "Looking for paths with length: 1 for node SRC and MAP4K4\n", + "i_search = 3\n", + "Looking for paths with length: 2 for node SRC and MAP4K4\n", + "i_search = 3\n", + "Looking for paths with length: 3 for node SRC and MAP4K4\n", + "[['SRC', 'MAPK8', 'MAP3K7', 'MAP4K4'], ['SRC', 'MAPK8', 'MAP3K1', 'MAP4K4']]\n", + "P45983 P12931\n", + "O43318 P45983\n", + "O95819 O43318\n", + "P45983 P12931\n", + "Q13233 P45983\n", + "O95819 Q13233\n", + "P12931 Q05397\n", + "P12931 P19022\n", + "P12931 Q14289\n", + "P12931 P35222\n", + "P12931 O75553\n", + "P12931 P08581\n", + "P12931 Q15139\n", + "P12931 O60716\n", + "P12931 Q13177\n", + "P45983 P12931\n", + "P35222 P46531\n", + "O75553 P46531\n", + "Q14289 Q05397\n", + "P08581 Q05397\n", + "P12830 P35222\n", + "P08581 P12830\n", + "Q15139 P12830\n", + "O60716 P12830\n", + "P19022 P35222\n", + "O60716 P19022\n", + "Q13177 P08670\n", + "O95819 O43318\n", + "O95819 Q13233\n", + "Q15139 P35222\n", + "O43318 P45983\n", + "Q13233 P45983\n", + "looking for paths in the network with length: 0 for node SRC and LATS1\n", + "looking for paths in the network with length: 1 for node SRC and LATS1\n", + "looking for paths in the network with length: 2 for node SRC and LATS1\n", + "looking for paths in the network with length: 3 for node SRC and LATS1\n", + "looking for paths in the network with length: 4 for node SRC and LATS1\n", + "looking for paths in the network with length: 5 for node SRC and LATS1\n", + "looking for paths in the network with length: 6 for node SRC and LATS1\n", + "i_search = 3\n", + "Looking for paths with length: 0 for node SRC and LATS1\n", + "i_search = 3\n", + "Looking for paths with length: 1 for node SRC and LATS1\n", + "i_search = 3\n", + "Looking for paths with length: 2 for node SRC and LATS1\n", + "i_search = 3\n", + "Looking for paths with length: 3 for node SRC and LATS1\n", + "[['SRC', 'RAF1', 'STK3', 'LATS1'], ['SRC', 'RAF1', 'STK4', 'LATS1'], ['SRC', 'PAK2', 'NF2', 'LATS1']]\n", + "P12931 P04049\n", + "P04049 Q13188\n", + "Q13188 O95835\n", + "P12931 P04049\n", + "P04049 Q13043\n", + "Q13043 O95835\n", + "P12931 Q13177\n", + "Q13177 P35240\n", + "P35240 O95835\n", + "P12931 Q05397\n", + "P12931 P19022\n", + "P12931 Q14289\n", + "P12931 P35222\n", + "P12931 O75553\n", + "P12931 P08581\n", + "P12931 Q15139\n", + "P12931 O60716\n", + "P12931 Q13177\n", + "P45983 P12931\n", + "P12931 P04049\n", + "P35222 P46531\n", + "O75553 P46531\n", + "Q14289 Q05397\n", + "P08581 Q05397\n", + "P12830 P35222\n", + "P08581 P12830\n", + "Q15139 P12830\n", + "O60716 P12830\n", + "P19022 P35222\n", + "O60716 P19022\n", + "Q13177 P08670\n", + "O95819 O43318\n", + "O95819 Q13233\n", + "Q13188 O95835\n", + "Q13043 O95835\n", + "P35240 O95835\n", + "Q13188 Q9NRM7\n", + "Q13043 Q9NRM7\n", + "P35240 Q9NRM7\n", + "Q15139 P35222\n", + "Q13177 P04049\n", + "Q13177 P35240\n", + "O43318 P45983\n", + "Q13233 P45983\n", + "P45983 Q13043\n", + "P04049 Q13188\n", + "P04049 Q13043\n", + "P35240 Q13188\n", + "P35240 Q13043\n", + "looking for paths in the network with length: 0 for node SRC and LATS2\n", + "looking for paths in the network with length: 1 for node SRC and LATS2\n", + "looking for paths in the network with length: 2 for node SRC and LATS2\n", + "looking for paths in the network with length: 3 for node SRC and LATS2\n", + "Found a path!\n", + "[['SRC', 'PAK2', 'NF2', 'LATS2'], ['SRC', 'RAF1', 'STK3', 'LATS2'], ['SRC', 'RAF1', 'STK4', 'LATS2']]\n", + "looking for paths in the network with length: 0 for node SRC and PTK2B\n", + "looking for paths in the network with length: 1 for node SRC and PTK2B\n", + "Found a path!\n", + "[['SRC', 'PTK2B']]\n", + "looking for paths in the network with length: 0 for node NOTCH1 and PTK2\n", + "looking for paths in the network with length: 1 for node NOTCH1 and PTK2\n", + "looking for paths in the network with length: 2 for node NOTCH1 and PTK2\n", + "looking for paths in the network with length: 3 for node NOTCH1 and PTK2\n", + "looking for paths in the network with length: 4 for node NOTCH1 and PTK2\n", + "looking for paths in the network with length: 5 for node NOTCH1 and PTK2\n", + "looking for paths in the network with length: 6 for node NOTCH1 and PTK2\n", + "i_search = 3\n", + "Looking for paths with length: 0 for node NOTCH1 and PTK2\n", + "i_search = 3\n", + "Looking for paths with length: 1 for node NOTCH1 and PTK2\n", + "i_search = 3\n", + "Looking for paths with length: 2 for node NOTCH1 and PTK2\n", + "i_search = 3\n", + "Looking for paths with length: 3 for node NOTCH1 and PTK2\n", + "[['NOTCH1', 'SMAD3', 'BCAR1', 'PTK2'], ['NOTCH1', 'LCK', 'PTPRH', 'PTK2']]\n", + "P84022 P46531\n", + "P56945 P84022\n", + "Q05397 P56945\n", + "P06239 P46531\n", + "Q9HD43 P06239\n", + "Q9HD43 Q05397\n", + "P12931 Q05397\n", + "P12931 P19022\n", + "P12931 Q14289\n", + "P12931 P35222\n", + "P12931 O75553\n", + "P12931 P08581\n", + "P12931 Q15139\n", + "P12931 O60716\n", + "P12931 Q13177\n", + "P45983 P12931\n", + "P12931 P04049\n", + "P12931 P56945\n", + "Q9HD43 P12931\n", + "P35222 P46531\n", + "O75553 P46531\n", + "P84022 P46531\n", + "P06239 P46531\n", + "Q14289 Q05397\n", + "P08581 Q05397\n", + "Q05397 P56945\n", + "Q05397 Q9HD43\n", + "Q9HD43 Q05397\n", + "P12830 P35222\n", + "P08581 P12830\n", + "Q15139 P12830\n", + "O60716 P12830\n", + "P19022 P35222\n", + "O60716 P19022\n", + "Q13177 P08670\n", + "O95819 O43318\n", + "O95819 Q13233\n", + "Q13188 O95835\n", + "Q13043 O95835\n", + "P35240 O95835\n", + "Q13188 Q9NRM7\n", + "Q13043 Q9NRM7\n", + "P35240 Q9NRM7\n", + "Q15139 P35222\n", + "Q13177 P04049\n", + "Q13177 P35240\n", + "O43318 P45983\n", + "Q13233 P45983\n", + "P45983 Q13043\n", + "P45983 P84022\n", + "O43318 P84022\n", + "P04049 Q13188\n", + "P04049 Q13043\n", + "P06239 P04049\n", + "P35240 Q13188\n", + "P35240 Q13043\n", + "P56945 P84022\n", + "Q9HD43 P56945\n", + "Q9HD43 P06239\n", + "looking for paths in the network with length: 0 for node NOTCH1 and CDH1\n", + "looking for paths in the network with length: 1 for node NOTCH1 and CDH1\n", + "looking for paths in the network with length: 2 for node NOTCH1 and CDH1\n", + "Found a path!\n", + "[['NOTCH1', 'CTNNB1', 'CDH1']]\n", + "looking for paths in the network with length: 0 for node NOTCH1 and CDH2\n", + "looking for paths in the network with length: 1 for node NOTCH1 and CDH2\n", + "looking for paths in the network with length: 2 for node NOTCH1 and CDH2\n", + "Found a path!\n", + "[['NOTCH1', 'CTNNB1', 'CDH2']]\n", + "looking for paths in the network with length: 0 for node NOTCH1 and VIM\n", + "looking for paths in the network with length: 1 for node NOTCH1 and VIM\n", + "looking for paths in the network with length: 2 for node NOTCH1 and VIM\n", + "looking for paths in the network with length: 3 for node NOTCH1 and VIM\n", + "looking for paths in the network with length: 4 for node NOTCH1 and VIM\n", + "looking for paths in the network with length: 5 for node NOTCH1 and VIM\n", + "looking for paths in the network with length: 6 for node NOTCH1 and VIM\n", + "i_search = 3\n", + "Looking for paths with length: 0 for node NOTCH1 and VIM\n", + "i_search = 3\n", + "Looking for paths with length: 1 for node NOTCH1 and VIM\n", + "i_search = 3\n", + "Looking for paths with length: 2 for node NOTCH1 and VIM\n", + "i_search = 3\n", + "Looking for paths with length: 3 for node NOTCH1 and VIM\n", + "looking for paths in the network with length: 0 for node NOTCH1 and MAP4K4\n", + "looking for paths in the network with length: 1 for node NOTCH1 and MAP4K4\n", + "looking for paths in the network with length: 2 for node NOTCH1 and MAP4K4\n", + "looking for paths in the network with length: 3 for node NOTCH1 and MAP4K4\n", + "Found a path!\n", + "[['NOTCH1', 'SMAD3', 'MAP3K7', 'MAP4K4']]\n", + "looking for paths in the network with length: 0 for node NOTCH1 and LATS1\n", + "looking for paths in the network with length: 1 for node NOTCH1 and LATS1\n", + "looking for paths in the network with length: 2 for node NOTCH1 and LATS1\n", + "looking for paths in the network with length: 3 for node NOTCH1 and LATS1\n", + "looking for paths in the network with length: 4 for node NOTCH1 and LATS1\n", + "looking for paths in the network with length: 5 for node NOTCH1 and LATS1\n", + "looking for paths in the network with length: 6 for node NOTCH1 and LATS1\n", + "i_search = 3\n", + "Looking for paths with length: 0 for node NOTCH1 and LATS1\n", + "i_search = 3\n", + "Looking for paths with length: 1 for node NOTCH1 and LATS1\n", + "i_search = 3\n", + "Looking for paths with length: 2 for node NOTCH1 and LATS1\n", + "i_search = 3\n", + "Looking for paths with length: 3 for node NOTCH1 and LATS1\n", + "[['NOTCH1', 'SMAD3', 'WWTR1', 'LATS1'], ['NOTCH1', 'CTNNB1', 'YAP1', 'LATS1'], ['NOTCH1', 'RUNX2', 'WWTR1', 'LATS1'], ['NOTCH1', 'RUNX2', 'YAP1', 'LATS1']]\n", + "P84022 P46531\n", + "Q9GZV5 P84022\n", + "O95835 Q9GZV5\n", + "P35222 P46531\n", + "P46937 P35222\n", + "O95835 P46937\n", + "Q13950 P46531\n", + "Q9GZV5 Q13950\n", + "O95835 Q9GZV5\n", + "Q13950 P46531\n", + "P46937 Q13950\n", + "O95835 P46937\n", + "P12931 Q05397\n", + "P12931 P19022\n", + "P12931 Q14289\n", + "P12931 P35222\n", + "P12931 O75553\n", + "P12931 P08581\n", + "P12931 Q15139\n", + "P12931 O60716\n", + "P12931 Q13177\n", + "P45983 P12931\n", + "P12931 P04049\n", + "P12931 P56945\n", + "Q9HD43 P12931\n", + "P35222 P46531\n", + "O75553 P46531\n", + "P84022 P46531\n", + "P06239 P46531\n", + "Q13950 P46531\n", + "Q14289 Q05397\n", + "P08581 Q05397\n", + "Q05397 P56945\n", + "Q05397 Q9HD43\n", + "Q9HD43 Q05397\n", + "P12830 P35222\n", + "P08581 P12830\n", + "Q15139 P12830\n", + "O60716 P12830\n", + "P19022 P35222\n", + "O60716 P19022\n", + "Q13177 P08670\n", + "O95819 O43318\n", + "O95819 Q13233\n", + "Q13188 O95835\n", + "Q13043 O95835\n", + "P35240 O95835\n", + "O95835 Q9GZV5\n", + "O95835 P46937\n", + "Q13188 Q9NRM7\n", + "Q13043 Q9NRM7\n", + "P35240 Q9NRM7\n", + "Q9NRM7 Q9GZV5\n", + "Q9NRM7 P46937\n", + "Q15139 P35222\n", + "P46937 P35222\n", + "Q13177 P04049\n", + "Q13177 P35240\n", + "O43318 P45983\n", + "Q13233 P45983\n", + "P45983 Q13043\n", + "P45983 P84022\n", + "O43318 P84022\n", + "P04049 Q13188\n", + "P04049 Q13043\n", + "P06239 P04049\n", + "P35240 Q13188\n", + "P35240 Q13043\n", + "P56945 P84022\n", + "Q9GZV5 P84022\n", + "P84022 Q13950\n", + "Q9HD43 P56945\n", + "Q9HD43 P06239\n", + "Q9GZV5 Q13950\n", + "P46937 Q13950\n", + "looking for paths in the network with length: 0 for node NOTCH1 and LATS2\n", + "looking for paths in the network with length: 1 for node NOTCH1 and LATS2\n", + "looking for paths in the network with length: 2 for node NOTCH1 and LATS2\n", + "looking for paths in the network with length: 3 for node NOTCH1 and LATS2\n", + "Found a path!\n", + "[['NOTCH1', 'SMAD3', 'WWTR1', 'LATS2'], ['NOTCH1', 'CTNNB1', 'YAP1', 'LATS2'], ['NOTCH1', 'RUNX2', 'WWTR1', 'LATS2'], ['NOTCH1', 'RUNX2', 'YAP1', 'LATS2']]\n", + "looking for paths in the network with length: 0 for node NOTCH1 and PTK2B\n", + "looking for paths in the network with length: 1 for node NOTCH1 and PTK2B\n", + "looking for paths in the network with length: 2 for node NOTCH1 and PTK2B\n", + "looking for paths in the network with length: 3 for node NOTCH1 and PTK2B\n", + "looking for paths in the network with length: 4 for node NOTCH1 and PTK2B\n", + "Found a path!\n", + "[['NOTCH1', 'SMAD3', 'BCAR1', 'PTK2', 'PTK2B'], ['NOTCH1', 'LCK', 'PTPRH', 'PTK2', 'PTK2B']]\n", + "looking for paths in the network with length: 0 for node PTK2 and CDH1\n", + "looking for paths in the network with length: 1 for node PTK2 and CDH1\n", + "looking for paths in the network with length: 2 for node PTK2 and CDH1\n", + "looking for paths in the network with length: 3 for node PTK2 and CDH1\n", + "looking for paths in the network with length: 4 for node PTK2 and CDH1\n", + "Found a path!\n", + "[['PTK2', 'PTPRH', 'SRC', 'PRKD1', 'CDH1'], ['PTK2', 'PTPRH', 'SRC', 'CTNND1', 'CDH1'], ['PTK2', 'PTPRH', 'SRC', 'MET', 'CDH1']]\n", + "looking for paths in the network with length: 0 for node PTK2 and CDH2\n", + "looking for paths in the network with length: 1 for node PTK2 and CDH2\n", + "looking for paths in the network with length: 2 for node PTK2 and CDH2\n", + "looking for paths in the network with length: 3 for node PTK2 and CDH2\n", + "Found a path!\n", + "[['PTK2', 'PTPRH', 'SRC', 'CDH2']]\n", + "looking for paths in the network with length: 0 for node PTK2 and VIM\n", + "looking for paths in the network with length: 1 for node PTK2 and VIM\n", + "looking for paths in the network with length: 2 for node PTK2 and VIM\n", + "looking for paths in the network with length: 3 for node PTK2 and VIM\n", + "looking for paths in the network with length: 4 for node PTK2 and VIM\n", + "Found a path!\n", + "[['PTK2', 'PTPRH', 'SRC', 'PAK2', 'VIM']]\n", + "looking for paths in the network with length: 0 for node PTK2 and MAP4K4\n", + "looking for paths in the network with length: 1 for node PTK2 and MAP4K4\n", + "looking for paths in the network with length: 2 for node PTK2 and MAP4K4\n", + "looking for paths in the network with length: 3 for node PTK2 and MAP4K4\n", + "looking for paths in the network with length: 4 for node PTK2 and MAP4K4\n", + "Found a path!\n", + "[['PTK2', 'SRC', 'MAPK8', 'MAP3K7', 'MAP4K4'], ['PTK2', 'SRC', 'MAPK8', 'MAP3K1', 'MAP4K4']]\n", + "looking for paths in the network with length: 0 for node PTK2 and LATS1\n", + "looking for paths in the network with length: 1 for node PTK2 and LATS1\n", + "looking for paths in the network with length: 2 for node PTK2 and LATS1\n", + "looking for paths in the network with length: 3 for node PTK2 and LATS1\n", + "looking for paths in the network with length: 4 for node PTK2 and LATS1\n", + "looking for paths in the network with length: 5 for node PTK2 and LATS1\n", + "Found a path!\n", + "[['PTK2', 'PTPRH', 'SRC', 'PAK2', 'NF2', 'LATS1'], ['PTK2', 'PTPRH', 'SRC', 'RAF1', 'STK3', 'LATS1'], ['PTK2', 'PTPRH', 'SRC', 'RAF1', 'STK4', 'LATS1'], ['PTK2', 'PTPRH', 'LCK', 'RAF1', 'STK3', 'LATS1'], ['PTK2', 'PTPRH', 'LCK', 'RAF1', 'STK4', 'LATS1']]\n", + "looking for paths in the network with length: 0 for node PTK2 and LATS2\n", + "looking for paths in the network with length: 1 for node PTK2 and LATS2\n", + "looking for paths in the network with length: 2 for node PTK2 and LATS2\n", + "looking for paths in the network with length: 3 for node PTK2 and LATS2\n", + "looking for paths in the network with length: 4 for node PTK2 and LATS2\n", + "looking for paths in the network with length: 5 for node PTK2 and LATS2\n", + "Found a path!\n", + "[['PTK2', 'PTPRH', 'SRC', 'PAK2', 'NF2', 'LATS2'], ['PTK2', 'PTPRH', 'SRC', 'RAF1', 'STK3', 'LATS2'], ['PTK2', 'PTPRH', 'SRC', 'RAF1', 'STK4', 'LATS2'], ['PTK2', 'PTPRH', 'LCK', 'RAF1', 'STK3', 'LATS2'], ['PTK2', 'PTPRH', 'LCK', 'RAF1', 'STK4', 'LATS2']]\n", + "looking for paths in the network with length: 0 for node PTK2 and PTK2B\n", + "looking for paths in the network with length: 1 for node PTK2 and PTK2B\n", + "Found a path!\n", + "[['PTK2', 'PTK2B']]\n", + "looking for paths in the network with length: 0 for node CDH1 and CDH2\n", + "looking for paths in the network with length: 1 for node CDH1 and CDH2\n", + "looking for paths in the network with length: 2 for node CDH1 and CDH2\n", + "looking for paths in the network with length: 3 for node CDH1 and CDH2\n", + "looking for paths in the network with length: 4 for node CDH1 and CDH2\n", + "looking for paths in the network with length: 5 for node CDH1 and CDH2\n", + "looking for paths in the network with length: 6 for node CDH1 and CDH2\n", + "i_search = 3\n", + "Looking for paths with length: 0 for node CDH1 and CDH2\n", + "i_search = 3\n", + "Looking for paths with length: 1 for node CDH1 and CDH2\n", + "i_search = 3\n", + "Looking for paths with length: 2 for node CDH1 and CDH2\n", + "i_search = 3\n", + "Looking for paths with length: 3 for node CDH1 and CDH2\n", + "[['CDH1', 'EGFR', 'CTNND1', 'CDH2']]\n", + "P12830 P00533\n", + "P00533 O60716\n", + "O60716 P19022\n", + "P12931 Q05397\n", + "P12931 P19022\n", + "P12931 Q14289\n", + "P12931 P35222\n", + "P12931 O75553\n", + "P12931 P08581\n", + "P12931 Q15139\n", + "P12931 O60716\n", + "P12931 Q13177\n", + "P45983 P12931\n", + "P12931 P04049\n", + "P12931 P56945\n", + "Q9HD43 P12931\n", + "P12931 P00533\n", + "P35222 P46531\n", + "O75553 P46531\n", + "P84022 P46531\n", + "P06239 P46531\n", + "Q13950 P46531\n", + "Q14289 Q05397\n", + "P08581 Q05397\n", + "Q05397 P56945\n", + "Q05397 Q9HD43\n", + "Q9HD43 Q05397\n", + "P00533 Q05397\n", + "P12830 P35222\n", + "P08581 P12830\n", + "Q15139 P12830\n", + "O60716 P12830\n", + "P12830 P00533\n", + "P19022 P35222\n", + "O60716 P19022\n", + "Q13177 P08670\n", + "O95819 O43318\n", + "O95819 Q13233\n", + "Q13188 O95835\n", + "Q13043 O95835\n", + "P35240 O95835\n", + "O95835 Q9GZV5\n", + "O95835 P46937\n", + "Q13188 Q9NRM7\n", + "Q13043 Q9NRM7\n", + "P35240 Q9NRM7\n", + "Q9NRM7 Q9GZV5\n", + "Q9NRM7 P46937\n", + "Q14289 P00533\n", + "Q15139 P35222\n", + "P46937 P35222\n", + "P00533 P35222\n", + "Q15139 P00533\n", + "P00533 O60716\n", + "Q13177 P04049\n", + "Q13177 P35240\n", + "O43318 P45983\n", + "Q13233 P45983\n", + "P45983 Q13043\n", + "P45983 P84022\n", + "O43318 P84022\n", + "P04049 Q13188\n", + "P04049 Q13043\n", + "P06239 P04049\n", + "P35240 Q13188\n", + "P35240 Q13043\n", + "P56945 P84022\n", + "Q9GZV5 P84022\n", + "P84022 Q13950\n", + "Q9HD43 P56945\n", + "P00533 P56945\n", + "Q9HD43 P06239\n", + "Q9GZV5 Q13950\n", + "P46937 Q13950\n", + "looking for paths in the network with length: 0 for node CDH1 and VIM\n", + "looking for paths in the network with length: 1 for node CDH1 and VIM\n", + "looking for paths in the network with length: 2 for node CDH1 and VIM\n", + "looking for paths in the network with length: 3 for node CDH1 and VIM\n", + "looking for paths in the network with length: 4 for node CDH1 and VIM\n", + "looking for paths in the network with length: 5 for node CDH1 and VIM\n", + "looking for paths in the network with length: 6 for node CDH1 and VIM\n", + "Found a path!\n", + "[['CDH1', 'EGFR', 'PTK2', 'PTPRH', 'SRC', 'PAK2', 'VIM']]\n", + "looking for paths in the network with length: 0 for node CDH1 and MAP4K4\n", + "looking for paths in the network with length: 1 for node CDH1 and MAP4K4\n", + "looking for paths in the network with length: 2 for node CDH1 and MAP4K4\n", + "looking for paths in the network with length: 3 for node CDH1 and MAP4K4\n", + "looking for paths in the network with length: 4 for node CDH1 and MAP4K4\n", + "looking for paths in the network with length: 5 for node CDH1 and MAP4K4\n", + "Found a path!\n", + "[['CDH1', 'CTNND1', 'SRC', 'MAPK8', 'MAP3K7', 'MAP4K4'], ['CDH1', 'CTNND1', 'SRC', 'MAPK8', 'MAP3K1', 'MAP4K4'], ['CDH1', 'PRKD1', 'SRC', 'MAPK8', 'MAP3K7', 'MAP4K4'], ['CDH1', 'PRKD1', 'SRC', 'MAPK8', 'MAP3K1', 'MAP4K4'], ['CDH1', 'MET', 'SRC', 'MAPK8', 'MAP3K7', 'MAP4K4'], ['CDH1', 'MET', 'SRC', 'MAPK8', 'MAP3K1', 'MAP4K4']]\n", + "looking for paths in the network with length: 0 for node CDH1 and LATS1\n", + "looking for paths in the network with length: 1 for node CDH1 and LATS1\n", + "looking for paths in the network with length: 2 for node CDH1 and LATS1\n", + "looking for paths in the network with length: 3 for node CDH1 and LATS1\n", + "looking for paths in the network with length: 4 for node CDH1 and LATS1\n", + "looking for paths in the network with length: 5 for node CDH1 and LATS1\n", + "looking for paths in the network with length: 6 for node CDH1 and LATS1\n", + "i_search = 3\n", + "Looking for paths with length: 0 for node CDH1 and LATS1\n", + "i_search = 3\n", + "Looking for paths with length: 1 for node CDH1 and LATS1\n", + "i_search = 3\n", + "Looking for paths with length: 2 for node CDH1 and LATS1\n", + "i_search = 3\n", + "Looking for paths with length: 3 for node CDH1 and LATS1\n", + "looking for paths in the network with length: 0 for node CDH1 and LATS2\n", + "looking for paths in the network with length: 1 for node CDH1 and LATS2\n", + "looking for paths in the network with length: 2 for node CDH1 and LATS2\n", + "looking for paths in the network with length: 3 for node CDH1 and LATS2\n", + "looking for paths in the network with length: 4 for node CDH1 and LATS2\n", + "looking for paths in the network with length: 5 for node CDH1 and LATS2\n", + "looking for paths in the network with length: 6 for node CDH1 and LATS2\n", + "i_search = 3\n", + "Looking for paths with length: 0 for node CDH1 and LATS2\n", + "i_search = 3\n", + "Looking for paths with length: 1 for node CDH1 and LATS2\n", + "i_search = 3\n", + "Looking for paths with length: 2 for node CDH1 and LATS2\n", + "i_search = 3\n", + "Looking for paths with length: 3 for node CDH1 and LATS2\n", + "looking for paths in the network with length: 0 for node CDH1 and PTK2B\n", + "looking for paths in the network with length: 1 for node CDH1 and PTK2B\n", + "looking for paths in the network with length: 2 for node CDH1 and PTK2B\n", + "looking for paths in the network with length: 3 for node CDH1 and PTK2B\n", + "Found a path!\n", + "[['CDH1', 'CTNND1', 'EGFR', 'PTK2B']]\n", + "looking for paths in the network with length: 0 for node CDH2 and VIM\n", + "looking for paths in the network with length: 1 for node CDH2 and VIM\n", + "looking for paths in the network with length: 2 for node CDH2 and VIM\n", + "looking for paths in the network with length: 3 for node CDH2 and VIM\n", + "looking for paths in the network with length: 4 for node CDH2 and VIM\n", + "looking for paths in the network with length: 5 for node CDH2 and VIM\n", + "looking for paths in the network with length: 6 for node CDH2 and VIM\n", + "i_search = 3\n", + "Looking for paths with length: 0 for node CDH2 and VIM\n", + "i_search = 3\n", + "Looking for paths with length: 1 for node CDH2 and VIM\n", + "i_search = 3\n", + "Looking for paths with length: 2 for node CDH2 and VIM\n", + "i_search = 3\n", + "Looking for paths with length: 3 for node CDH2 and VIM\n", + "looking for paths in the network with length: 0 for node CDH2 and MAP4K4\n", + "looking for paths in the network with length: 1 for node CDH2 and MAP4K4\n", + "looking for paths in the network with length: 2 for node CDH2 and MAP4K4\n", + "looking for paths in the network with length: 3 for node CDH2 and MAP4K4\n", + "looking for paths in the network with length: 4 for node CDH2 and MAP4K4\n", + "Found a path!\n", + "[['CDH2', 'SRC', 'MAPK8', 'MAP3K7', 'MAP4K4'], ['CDH2', 'SRC', 'MAPK8', 'MAP3K1', 'MAP4K4']]\n", + "looking for paths in the network with length: 0 for node CDH2 and LATS1\n", + "looking for paths in the network with length: 1 for node CDH2 and LATS1\n", + "looking for paths in the network with length: 2 for node CDH2 and LATS1\n", + "looking for paths in the network with length: 3 for node CDH2 and LATS1\n", + "looking for paths in the network with length: 4 for node CDH2 and LATS1\n", + "looking for paths in the network with length: 5 for node CDH2 and LATS1\n", + "looking for paths in the network with length: 6 for node CDH2 and LATS1\n", + "i_search = 3\n", + "Looking for paths with length: 0 for node CDH2 and LATS1\n", + "i_search = 3\n", + "Looking for paths with length: 1 for node CDH2 and LATS1\n", + "i_search = 3\n", + "Looking for paths with length: 2 for node CDH2 and LATS1\n", + "i_search = 3\n", + "Looking for paths with length: 3 for node CDH2 and LATS1\n", + "looking for paths in the network with length: 0 for node CDH2 and LATS2\n", + "looking for paths in the network with length: 1 for node CDH2 and LATS2\n", + "looking for paths in the network with length: 2 for node CDH2 and LATS2\n", + "looking for paths in the network with length: 3 for node CDH2 and LATS2\n", + "looking for paths in the network with length: 4 for node CDH2 and LATS2\n", + "looking for paths in the network with length: 5 for node CDH2 and LATS2\n", + "looking for paths in the network with length: 6 for node CDH2 and LATS2\n", + "i_search = 3\n", + "Looking for paths with length: 0 for node CDH2 and LATS2\n", + "i_search = 3\n", + "Looking for paths with length: 1 for node CDH2 and LATS2\n", + "i_search = 3\n", + "Looking for paths with length: 2 for node CDH2 and LATS2\n", + "i_search = 3\n", + "Looking for paths with length: 3 for node CDH2 and LATS2\n", + "looking for paths in the network with length: 0 for node CDH2 and PTK2B\n", + "looking for paths in the network with length: 1 for node CDH2 and PTK2B\n", + "looking for paths in the network with length: 2 for node CDH2 and PTK2B\n", + "looking for paths in the network with length: 3 for node CDH2 and PTK2B\n", + "Found a path!\n", + "[['CDH2', 'CTNND1', 'EGFR', 'PTK2B']]\n", + "looking for paths in the network with length: 0 for node VIM and MAP4K4\n", + "looking for paths in the network with length: 1 for node VIM and MAP4K4\n", + "looking for paths in the network with length: 2 for node VIM and MAP4K4\n", + "looking for paths in the network with length: 3 for node VIM and MAP4K4\n", + "looking for paths in the network with length: 4 for node VIM and MAP4K4\n", + "looking for paths in the network with length: 5 for node VIM and MAP4K4\n", + "Found a path!\n", + "[['VIM', 'PAK2', 'SRC', 'MAPK8', 'MAP3K7', 'MAP4K4'], ['VIM', 'PAK2', 'SRC', 'MAPK8', 'MAP3K1', 'MAP4K4']]\n", + "looking for paths in the network with length: 0 for node VIM and LATS1\n", + "looking for paths in the network with length: 1 for node VIM and LATS1\n", + "looking for paths in the network with length: 2 for node VIM and LATS1\n", + "looking for paths in the network with length: 3 for node VIM and LATS1\n", + "looking for paths in the network with length: 4 for node VIM and LATS1\n", + "looking for paths in the network with length: 5 for node VIM and LATS1\n", + "looking for paths in the network with length: 6 for node VIM and LATS1\n", + "i_search = 3\n", + "Looking for paths with length: 0 for node VIM and LATS1\n", + "i_search = 3\n", + "Looking for paths with length: 1 for node VIM and LATS1\n", + "i_search = 3\n", + "Looking for paths with length: 2 for node VIM and LATS1\n", + "i_search = 3\n", + "Looking for paths with length: 3 for node VIM and LATS1\n", + "looking for paths in the network with length: 0 for node VIM and LATS2\n", + "looking for paths in the network with length: 1 for node VIM and LATS2\n", + "looking for paths in the network with length: 2 for node VIM and LATS2\n", + "looking for paths in the network with length: 3 for node VIM and LATS2\n", + "looking for paths in the network with length: 4 for node VIM and LATS2\n", + "looking for paths in the network with length: 5 for node VIM and LATS2\n", + "looking for paths in the network with length: 6 for node VIM and LATS2\n", + "i_search = 3\n", + "Looking for paths with length: 0 for node VIM and LATS2\n", + "i_search = 3\n", + "Looking for paths with length: 1 for node VIM and LATS2\n", + "i_search = 3\n", + "Looking for paths with length: 2 for node VIM and LATS2\n", + "i_search = 3\n", + "Looking for paths with length: 3 for node VIM and LATS2\n", + "looking for paths in the network with length: 0 for node VIM and PTK2B\n", + "looking for paths in the network with length: 1 for node VIM and PTK2B\n", + "looking for paths in the network with length: 2 for node VIM and PTK2B\n", + "looking for paths in the network with length: 3 for node VIM and PTK2B\n", + "looking for paths in the network with length: 4 for node VIM and PTK2B\n", + "looking for paths in the network with length: 5 for node VIM and PTK2B\n", + "Found a path!\n", + "[['VIM', 'PAK2', 'SRC', 'PTPRH', 'PTK2', 'PTK2B']]\n", + "looking for paths in the network with length: 0 for node MAP4K4 and LATS1\n", + "looking for paths in the network with length: 1 for node MAP4K4 and LATS1\n", + "looking for paths in the network with length: 2 for node MAP4K4 and LATS1\n", + "looking for paths in the network with length: 3 for node MAP4K4 and LATS1\n", + "looking for paths in the network with length: 4 for node MAP4K4 and LATS1\n", + "Found a path!\n", + "[['MAP4K4', 'MAP3K7', 'MAPK8', 'STK4', 'LATS1'], ['MAP4K4', 'MAP3K1', 'MAPK8', 'STK4', 'LATS1']]\n", + "looking for paths in the network with length: 0 for node MAP4K4 and LATS2\n", + "looking for paths in the network with length: 1 for node MAP4K4 and LATS2\n", + "looking for paths in the network with length: 2 for node MAP4K4 and LATS2\n", + "looking for paths in the network with length: 3 for node MAP4K4 and LATS2\n", + "looking for paths in the network with length: 4 for node MAP4K4 and LATS2\n", + "Found a path!\n", + "[['MAP4K4', 'MAP3K7', 'MAPK8', 'STK4', 'LATS2'], ['MAP4K4', 'MAP3K1', 'MAPK8', 'STK4', 'LATS2']]\n", + "looking for paths in the network with length: 0 for node MAP4K4 and PTK2B\n", + "looking for paths in the network with length: 1 for node MAP4K4 and PTK2B\n", + "looking for paths in the network with length: 2 for node MAP4K4 and PTK2B\n", + "looking for paths in the network with length: 3 for node MAP4K4 and PTK2B\n", + "looking for paths in the network with length: 4 for node MAP4K4 and PTK2B\n", + "Found a path!\n", + "[['MAP4K4', 'MAP3K7', 'MAPK8', 'SRC', 'PTK2B'], ['MAP4K4', 'MAP3K1', 'MAPK8', 'SRC', 'PTK2B']]\n", + "looking for paths in the network with length: 0 for node LATS1 and LATS2\n", + "looking for paths in the network with length: 1 for node LATS1 and LATS2\n", + "looking for paths in the network with length: 2 for node LATS1 and LATS2\n", + "looking for paths in the network with length: 3 for node LATS1 and LATS2\n", + "looking for paths in the network with length: 4 for node LATS1 and LATS2\n", + "looking for paths in the network with length: 5 for node LATS1 and LATS2\n", + "looking for paths in the network with length: 6 for node LATS1 and LATS2\n", + "i_search = 3\n", + "Looking for paths with length: 0 for node LATS1 and LATS2\n", + "i_search = 3\n", + "Looking for paths with length: 1 for node LATS1 and LATS2\n", + "i_search = 3\n", + "Looking for paths with length: 2 for node LATS1 and LATS2\n", + "i_search = 3\n", + "Looking for paths with length: 3 for node LATS1 and LATS2\n", + "looking for paths in the network with length: 0 for node LATS1 and PTK2B\n", + "looking for paths in the network with length: 1 for node LATS1 and PTK2B\n", + "looking for paths in the network with length: 2 for node LATS1 and PTK2B\n", + "looking for paths in the network with length: 3 for node LATS1 and PTK2B\n", + "looking for paths in the network with length: 4 for node LATS1 and PTK2B\n", + "looking for paths in the network with length: 5 for node LATS1 and PTK2B\n", + "looking for paths in the network with length: 6 for node LATS1 and PTK2B\n", + "Found a path!\n", + "[['LATS1', 'STK3', 'RAF1', 'LCK', 'PTPRH', 'PTK2', 'PTK2B'], ['LATS1', 'STK3', 'RAF1', 'SRC', 'PTPRH', 'PTK2', 'PTK2B'], ['LATS1', 'STK4', 'RAF1', 'LCK', 'PTPRH', 'PTK2', 'PTK2B'], ['LATS1', 'STK4', 'RAF1', 'SRC', 'PTPRH', 'PTK2', 'PTK2B'], ['LATS1', 'NF2', 'PAK2', 'SRC', 'PTPRH', 'PTK2', 'PTK2B']]\n", + "looking for paths in the network with length: 0 for node LATS2 and PTK2B\n", + "looking for paths in the network with length: 1 for node LATS2 and PTK2B\n", + "looking for paths in the network with length: 2 for node LATS2 and PTK2B\n", + "looking for paths in the network with length: 3 for node LATS2 and PTK2B\n", + "looking for paths in the network with length: 4 for node LATS2 and PTK2B\n", + "looking for paths in the network with length: 5 for node LATS2 and PTK2B\n", + "looking for paths in the network with length: 6 for node LATS2 and PTK2B\n", + "Found a path!\n", + "[['LATS2', 'STK3', 'RAF1', 'LCK', 'PTPRH', 'PTK2', 'PTK2B'], ['LATS2', 'STK3', 'RAF1', 'SRC', 'PTPRH', 'PTK2', 'PTK2B'], ['LATS2', 'STK4', 'RAF1', 'LCK', 'PTPRH', 'PTK2', 'PTK2B'], ['LATS2', 'STK4', 'RAF1', 'SRC', 'PTPRH', 'PTK2', 'PTK2B'], ['LATS2', 'NF2', 'PAK2', 'SRC', 'PTPRH', 'PTK2', 'PTK2B']]\n", + "CPU times: user 1min 50s, sys: 22.9 ms, total: 1min 50s\n", + "Wall time: 1min 50s\n" + ] + } + ], + "source": [ + "%%time\n", + "new_net1.complete_connection(mode=\"ALL\", maxlen=6, k_mean=\"tight\", only_signed=True, connect_node_when_first_introduced=True, consensus=True)" + ] + }, + { + "cell_type": "markdown", + "id": "c6510316-2f47-4e71-89e0-b93da0657897", + "metadata": {}, + "source": [ + "#### 2E. Visualize final network" + ] + }, + { + "cell_type": "code", + "execution_count": 9, + "id": "152b9434", + "metadata": {}, + "outputs": [ + { + "data": { + "image/svg+xml": [ + "\n", + "\n", + "\n", + "\n", + "\n", + "\n", + "%3\n", + "\n", + "\n", + "\n", + "SRC\n", + "\n", + "SRC\n", + "\n", + "\n", + "\n", + "PTK2\n", + "\n", + "PTK2\n", + "\n", + "\n", + "\n", + "SRC->PTK2\n", + "\n", + "\n", + "\n", + "\n", + "\n", + "CDH2\n", + "\n", + "CDH2\n", + "\n", + "\n", + "\n", + "SRC->CDH2\n", + "\n", + "\n", + "\n", + "\n", + "\n", + "\n", + "PTK2B\n", + "\n", + "PTK2B\n", + "\n", + "\n", + "\n", + "SRC->PTK2B\n", + "\n", + "\n", + "\n", + "\n", + "\n", + "CTNNB1\n", + "\n", + "CTNNB1\n", + "\n", + "\n", + "\n", + "SRC->CTNNB1\n", + "\n", + "\n", + "\n", + "\n", + "\n", + "DAB1\n", + "\n", + "DAB1\n", + "\n", + "\n", + "\n", + "SRC->DAB1\n", + "\n", + "\n", + "\n", + "\n", + "\n", + "MET\n", + "\n", + "MET\n", + "\n", + "\n", + "\n", + "SRC->MET\n", + "\n", + "\n", + "\n", + "\n", + "\n", + "\n", + "PRKD1\n", + "\n", + "PRKD1\n", + "\n", + "\n", + "\n", + "SRC->PRKD1\n", + "\n", + "\n", + "\n", + "\n", + "\n", + "CTNND1\n", + "\n", + "CTNND1\n", + "\n", + "\n", + "\n", + "SRC->CTNND1\n", + "\n", + "\n", + "\n", + "\n", + "\n", + "PAK2\n", + "\n", + "PAK2\n", + "\n", + "\n", + "\n", + "SRC->PAK2\n", + "\n", + "\n", + "\n", + "\n", + "\n", + "RAF1\n", + "\n", + "RAF1\n", + "\n", + "\n", + "\n", + "SRC->RAF1\n", + "\n", + "\n", + "\n", + "\n", + "\n", + "BCAR1\n", + "\n", + "BCAR1\n", + "\n", + "\n", + "\n", + "SRC->BCAR1\n", + "\n", + "\n", + "\n", + "\n", + "\n", + "EGFR\n", + "\n", + "EGFR\n", + "\n", + "\n", + "\n", + "SRC->EGFR\n", + "\n", + "\n", + "\n", + "\n", + "\n", + "PTK2->BCAR1\n", + "\n", + "\n", + "\n", + "\n", + "\n", + "PTPRH\n", + "\n", + "PTPRH\n", + "\n", + "\n", + "\n", + "PTK2->PTPRH\n", + "\n", + "\n", + "\n", + "\n", + "\n", + "\n", + "CDH2->CTNNB1\n", + "\n", + "\n", + "\n", + "\n", + "\n", + "PTK2B->PTK2\n", + "\n", + "\n", + "\n", + "\n", + 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"\n", + "\n", + "NF2\n", + "\n", + "NF2\n", + "\n", + "\n", + "\n", + "PAK2->NF2\n", + "\n", + "\n", + "\n", + "\n", + "\n", + "MAPK8\n", + "\n", + "MAPK8\n", + "\n", + "\n", + "\n", + "MAPK8->SRC\n", + "\n", + "\n", + "\n", + "\n", + "\n", + "STK4\n", + "\n", + "STK4\n", + "\n", + "\n", + "\n", + "MAPK8->STK4\n", + "\n", + "\n", + "\n", + "\n", + "\n", + "SMAD3\n", + "\n", + "SMAD3\n", + "\n", + "\n", + "\n", + "MAPK8->SMAD3\n", + "\n", + "\n", + "\n", + "\n", + "\n", + "MAP3K7\n", + "\n", + "MAP3K7\n", + "\n", + "\n", + "\n", + "MAP3K7->MAPK8\n", + "\n", + "\n", + "\n", + "\n", + "\n", + "MAP3K7->SMAD3\n", + "\n", + "\n", + "\n", + "\n", + "\n", + "\n", + "MAP4K4\n", + "\n", + "MAP4K4\n", + "\n", + "\n", + "\n", + "MAP4K4->MAP3K7\n", + "\n", + "\n", + "\n", + "\n", + "\n", + "MAP3K1\n", + "\n", + "MAP3K1\n", + "\n", + "\n", + "\n", + "MAP4K4->MAP3K1\n", + "\n", + "\n", + "\n", + "\n", + "\n", + "MAP3K1->MAPK8\n", + "\n", + "\n", + "\n", + "\n", + "\n", + "STK3\n", + "\n", + "STK3\n", + "\n", + "\n", + "\n", + "RAF1->STK3\n", + "\n", + "\n", + "\n", + "\n", + "\n", + "\n", + "RAF1->STK4\n", + "\n", + "\n", + "\n", + "\n", + "\n", + "\n", + "LATS1\n", + "\n", + "LATS1\n", + "\n", + "\n", + "\n", + "STK3->LATS1\n", + "\n", + "\n", + "\n", + "\n", + "\n", + "LATS2\n", + "\n", + "LATS2\n", + "\n", + "\n", + "\n", + "STK3->LATS2\n", + "\n", + "\n", + "\n", + "\n", + "\n", + "WWTR1\n", + "\n", + "WWTR1\n", + "\n", + "\n", + "\n", + "LATS1->WWTR1\n", + "\n", + "\n", + "\n", + "\n", + "\n", + "\n", + "YAP1\n", + "\n", + "YAP1\n", + "\n", + "\n", + "\n", + "LATS1->YAP1\n", + "\n", + "\n", + "\n", + "\n", + "\n", + "STK4->LATS1\n", + "\n", + "\n", + "\n", + "\n", + "\n", + "STK4->LATS2\n", + "\n", + "\n", + "\n", + "\n", + "\n", + "NF2->STK3\n", + "\n", + "\n", + "\n", + "\n", + "\n", + "NF2->LATS1\n", + "\n", + "\n", + "\n", + "\n", + "\n", + "NF2->STK4\n", + "\n", + "\n", + "\n", + "\n", + "\n", + "NF2->LATS2\n", + "\n", + "\n", + "\n", + "\n", + "\n", + "LATS2->WWTR1\n", + "\n", + "\n", + "\n", + "\n", + "\n", + "\n", + "LATS2->YAP1\n", + "\n", + "\n", + "\n", + "\n", + "\n", + "\n", + "SMAD3->NOTCH1\n", + "\n", + "\n", + "\n", + "\n", + "\n", + "RUNX2\n", + "\n", + "RUNX2\n", + "\n", + "\n", + "\n", + "SMAD3->RUNX2\n", + "\n", + "\n", + "\n", + "\n", + "\n", + "\n", + "BCAR1->SMAD3\n", + "\n", + "\n", + "\n", + "\n", + "\n", + "\n", + "LCK\n", + "\n", + "LCK\n", + "\n", + "\n", + "\n", + "LCK->NOTCH1\n", + "\n", + "\n", + "\n", + "\n", + "\n", + "LCK->RAF1\n", + "\n", + "\n", + "\n", + "\n", + "\n", + "PTPRH->SRC\n", + "\n", + "\n", + "\n", + "\n", + "\n", + "\n", + "PTPRH->PTK2\n", + "\n", + "\n", + "\n", + "\n", + "\n", + "\n", + "PTPRH->BCAR1\n", + "\n", + "\n", + "\n", + "\n", + "\n", + "\n", + "PTPRH->LCK\n", + "\n", + "\n", + "\n", + "\n", + "\n", + "\n", + "WWTR1->SMAD3\n", + "\n", + "\n", + "\n", + "\n", + "\n", + "WWTR1->RUNX2\n", + "\n", + "\n", + "\n", + "\n", + "\n", + "YAP1->CTNNB1\n", + "\n", + "\n", + "\n", + "\n", + "\n", + "YAP1->RUNX2\n", + "\n", + "\n", + "\n", + "\n", + "\n", + "\n", + "RUNX2->NOTCH1\n", + "\n", + "\n", + "\n", + "\n", + "\n", + "\n", + "EGFR->PTK2\n", + "\n", + "\n", + "\n", + "\n", + "\n", + "EGFR->CTNNB1\n", + "\n", + "\n", + "\n", + "\n", + "\n", + "EGFR->CTNND1\n", + "\n", + "\n", + "\n", + "\n", + "\n", + "\n", + "EGFR->BCAR1\n", + "\n", + "\n", + "\n", + "\n", + "\n", + "\n" + ], + "text/plain": [ + "" + ] + }, + "metadata": {}, + "output_type": "display_data" + } + ], + "source": [ + "#Visualize network\n", + "visualizer1 = NetworkVisualizer(new_net1, color_by='effect')\n", + "visualizer1.render(output_file='network2')" + ] + }, + { + "cell_type": "code", + "execution_count": null, + "id": "80b84e81-abc2-4aae-ad1c-3ebf00355b98", + "metadata": {}, + "outputs": [], + "source": [ + "#Visualize a specific nodes and \n", + "visualizer1 = NetworkVisualizer(new_net1, predefined_node = \"SRC\",color_by='effect')\n", + "visualizer1.render(output_file='network2')" + ] + }, + { + "cell_type": "code", + "execution_count": 15, + "id": "0aa6d076-5310-462e-aa0e-f69da822b962", + "metadata": {}, + "outputs": [ + { + "data": { + "text/html": [ + "
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sourcetargetTypeEffectReferences
6821P12931Q05397NonestimulationAdhesome:10085298;Adhesome:10592173;Adhesome:1...
32968P12931P19022NoneinhibitionACSN:15782139;ACSN:16371504;ACSN:16492141;ACSN...
5154P12931Q14289NonestimulationAdhesome:10329689;Adhesome:10521452;Adhesome:1...
44795Q14289Q05397NonestimulationAdhesome:16760434;HPRD:16760434;KEA:12960434;K...
11582P12931P35222NonestimulationACSN:10593980;ACSN:12123611;ACSN:15782139;ACSN...
..................
67482P00533Q05397NonestimulationACSN:10545505;ACSN:16919435;ACSN:17496910;ACSN...
7631Q14289P00533NonestimulationCA1:11274221;HPRD:10777553;InnateDB:14963038;S...
73973P00533P35222NonestimulationACSN:12040186;ACSN:14585353;ACSN:17496910;ACSN...
2907Q15139P00533NonestimulationCancerCellMap:10523301;CancerCellMap:2984676;C...
78053P00533P56945NoneinhibitionKEA:17570479;ProtMapper:15951569;SPIKE_LC:1714...
\n", + "

71 rows × 5 columns

\n", + "
" + ], + "text/plain": [ + " source target Type Effect \\\n", + "6821 P12931 Q05397 None stimulation \n", + "32968 P12931 P19022 None inhibition \n", + "5154 P12931 Q14289 None stimulation \n", + "44795 Q14289 Q05397 None stimulation \n", + "11582 P12931 P35222 None stimulation \n", + "... ... ... ... ... \n", + "67482 P00533 Q05397 None stimulation \n", + "7631 Q14289 P00533 None stimulation \n", + "73973 P00533 P35222 None stimulation \n", + "2907 Q15139 P00533 None stimulation \n", + "78053 P00533 P56945 None inhibition \n", + "\n", + " References \n", + "6821 Adhesome:10085298;Adhesome:10592173;Adhesome:1... \n", + "32968 ACSN:15782139;ACSN:16371504;ACSN:16492141;ACSN... \n", + "5154 Adhesome:10329689;Adhesome:10521452;Adhesome:1... \n", + "44795 Adhesome:16760434;HPRD:16760434;KEA:12960434;K... \n", + "11582 ACSN:10593980;ACSN:12123611;ACSN:15782139;ACSN... \n", + "... ... \n", + "67482 ACSN:10545505;ACSN:16919435;ACSN:17496910;ACSN... \n", + "7631 CA1:11274221;HPRD:10777553;InnateDB:14963038;S... \n", + "73973 ACSN:12040186;ACSN:14585353;ACSN:17496910;ACSN... \n", + "2907 CancerCellMap:10523301;CancerCellMap:2984676;C... \n", + "78053 KEA:17570479;ProtMapper:15951569;SPIKE_LC:1714... \n", + "\n", + "[71 rows x 5 columns]" + ] + }, + "execution_count": 15, + "metadata": {}, + "output_type": "execute_result" + } + ], + "source": [ + "#We can access to the edges of the network\n", + "new_net1.edges" + ] + }, + { + "cell_type": "code", + "execution_count": 13, + "id": "9540f33d-68f8-4c98-b68e-3e3d1497467e", + "metadata": {}, + "outputs": [ + { + "name": "stdout", + "output_type": "stream", + "text": [ + " Genesymbol in_tissue\n", + "0 SRC True\n", + "1 NOTCH1 True\n", + "2 PTK2 True\n", + "3 CDH1 True\n", + "4 CDH2 True\n", + "5 VIM True\n", + "6 MAP4K4 True\n", + "7 LATS1 True\n", + "8 LATS2 True\n", + "9 PTK2B True\n", + "10 CTNNB1 True\n", + "11 DAB1 True\n", + "12 MET True\n", + "13 PRKD1 True\n", + "14 CTNND1 True\n", + "15 PAK2 True\n", + "16 MAPK8 True\n", + "17 MAP3K7 True\n", + "18 MAP3K1 True\n", + "19 RAF1 True\n", + "20 STK3 True\n", + "21 STK4 True\n", + "22 NF2 True\n", + "23 SMAD3 True\n", + "24 BCAR1 True\n", + "25 LCK True\n", + "26 PTPRH True\n", + "27 WWTR1 True\n", + "28 YAP1 True\n", + "29 RUNX2 True\n", + "30 EGFR True\n" + ] + } + ], + "source": [ + "annot = Ontology()\n", + "#user_defined_tissue = 'breast cancer'\n", + "results_df = annot.check_tissue_annotations(genes_df = new_net1.nodes, tissue = 'colorectal cancer')\n", + "print(results_df)" + ] + }, + { + "cell_type": "code", + "execution_count": 12, + "id": "fbd98405-045a-4316-8174-e96e9a71d9ee", + "metadata": {}, + "outputs": [ + { + "data": { + "image/svg+xml": [ + "\n", + "\n", + "\n", + "\n", + "\n", + "\n", + "%3\n", + "\n", + "\n", + "\n", + "SRC\n", + "\n", + "SRC\n", + "\n", + "\n", + "\n", + "PTK2\n", + "\n", + "PTK2\n", + "\n", + "\n", + "\n", + "SRC->PTK2\n", + "\n", + "\n", + "\n", + "\n", + "\n", + "CDH2\n", + "\n", + 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"output_type": "display_data" + } + ], + "source": [ + "network_visualizer = NetworkVisualizer(new_net1)\n", + "network_visualizer.tissue_mapping(results_df)\n", + "network_visualizer.render()" + ] + }, + { + "cell_type": "code", + "execution_count": 14, + "id": "6762228b-7e6c-4711-a07a-660c77f406e5", + "metadata": {}, + "outputs": [ + { + "data": { + "image/svg+xml": [ + "\n", + "\n", + "\n", + "\n", + "\n", + "\n", + "%3\n", + "\n", + "\n", + "\n", + "CDH1\n", + "\n", + "CDH1\n", + "\n", + "\n", + "\n", + "EGFR\n", + "\n", + "EGFR\n", + "\n", + "\n", + "\n", + "CDH1->EGFR\n", + "\n", + "\n", + "\n", + "\n", + "\n", + "CTNND1\n", + "\n", + "CTNND1\n", + "\n", + "\n", + "\n", + "EGFR->CTNND1\n", + "\n", + "\n", + "\n", + "\n", + "\n", + "\n", + "PTK2\n", + "\n", + "PTK2\n", + "\n", + "\n", + "\n", + "EGFR->PTK2\n", + "\n", + "\n", + "\n", + "\n", + "\n", + "CTNNB1\n", + "\n", + "CTNNB1\n", + "\n", + "\n", + "\n", + "EGFR->CTNNB1\n", + "\n", + "\n", + "\n", + "\n", + "\n", + "BCAR1\n", + "\n", + "BCAR1\n", + "\n", + "\n", + "\n", + "EGFR->BCAR1\n", + "\n", + "\n", + "\n", + "\n", + "\n", + "\n", + "SRC\n", + "\n", + "SRC\n", + "\n", + "\n", + "\n", + "SRC->EGFR\n", + "\n", + "\n", + "\n", + "\n", + "\n", + "PTK2B\n", + "\n", + "PTK2B\n", + "\n", + "\n", + "\n", + "PTK2B->EGFR\n", + "\n", + "\n", + "\n", + "\n", + "\n", + "PRKD1\n", + "\n", + "PRKD1\n", + "\n", + "\n", + "\n", + "PRKD1->EGFR\n", + "\n", + "\n", + "\n", + "\n", + "\n" + ], + "text/plain": [ + "" + ] + }, + "metadata": {}, + "output_type": "display_data" + } + ], + "source": [ + "visualizer = NetworkVisualizer(new_net1, predefined_node=\"EGFR\",color_by='effect')\n", + "visualizer.render()" + ] + }, + { + "cell_type": "markdown", + "id": "57cabbaa", + "metadata": {}, + "source": [ + "### We can access the network object edges to explore which interactions are in our network" + ] + }, + { + "cell_type": "markdown", + "id": "2a250d98", + "metadata": {}, + "source": [ + "# If the all_interaction database of omnipath is not sufficient, we can change it or extend it. To do it, we can use the Resources object:" + ] + }, + { + "cell_type": "code", + "execution_count": 10, + "id": "794f4de1", + "metadata": {}, + "outputs": [], + "source": [ + "interactions = op.interactions.AllInteractions.get() #first we get the interactions from omnipath" + ] + }, + { + "cell_type": "markdown", + "id": "aeec437c", + "metadata": {}, + "source": [ + "### Then, we can add allInteractions in the Resources object" + ] + }, + { + "cell_type": "code", + "execution_count": 11, + "id": "d45b7920", + "metadata": {}, + "outputs": [], + "source": [ + "resources = Resources()\n", + "resources.add_database(interactions)" + ] + }, + { + "cell_type": "code", + "execution_count": 12, + "id": "8dfed589", + "metadata": {}, + "outputs": [ + { + "data": { + "text/html": [ + "
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sourcetargetis_directedis_stimulationis_inhibitionconsensus_directionconsensus_stimulationconsensus_inhibitioncuration_effortreferencessourcestypen_sourcesn_primary_sourcesn_referencesreferences_stripped
0P0DP23P48995TrueFalseTrueTrueFalseTrue3TRIP:11290752;TRIP:11983166;TRIP:12601176TRIPpost_translational11311290752;11983166;12601176
1P0DP25P48995TrueFalseTrueTrueFalseTrue3TRIP:11290752;TRIP:11983166;TRIP:12601176TRIPpost_translational11311290752;11983166;12601176
2P0DP24P48995TrueFalseTrueTrueFalseTrue3TRIP:11290752;TRIP:11983166;TRIP:12601176TRIPpost_translational11311290752;11983166;12601176
3Q03135P48995TrueTrueFalseTrueTrueFalse13DIP:19897728;HPRD:12732636;IntAct:19897728;Lit...DIP;HPRD;IntAct;Lit-BM-17;TRIPpost_translational55810980191;12732636;14551243;16822931;18430726;1...
4P14416P48995TrueTrueFalseTrueTrueFalse1TRIP:18261457TRIPpost_translational11118261457
...................................................
276174439260P35348TrueFalseFalseFalseFalseFalse3Cellinker:10433504;Cellinker:7651358;Cellinker...Cellinker;Guide2Pharma_Cellinkersmall_molecule_protein21310433504;7651358;8564227
2761755202Q13639TrueFalseFalseFalseFalseFalse10Cellinker:10646498;Cellinker:10683202;Cellinke...Cellinker;Guide2Pharma_Cellinkersmall_molecule_protein211010646498;10683202;10821780;11030734;11218067;1...
2761766305Q6DWJ6TrueFalseFalseFalseFalseFalse1Cellinker:26349500Cellinker;Guide2Pharma_Cellinkersmall_molecule_protein21126349500
276177643961Q9GZU1TrueFalseFalseFalseFalseFalse1Cellinker:20802798Cellinker;Guide2Pharma_Cellinkersmall_molecule_protein21120802798
276178448457Q13258TrueFalseFalseFalseFalseFalse4Cellinker:10448933;Cellinker:16604093;Cellinke...Cellinker;Guide2Pharma_Cellinkersmall_molecule_protein21410448933;16604093;7642548;9579725
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276179 rows × 16 columns

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" + ], + "text/plain": [ + " source target is_directed is_stimulation is_inhibition \\\n", + "0 P0DP23 P48995 True False True \n", + "1 P0DP25 P48995 True False True \n", + "2 P0DP24 P48995 True False True \n", + "3 Q03135 P48995 True True False \n", + "4 P14416 P48995 True True False \n", + "... ... ... ... ... ... \n", + "276174 439260 P35348 True False False \n", + "276175 5202 Q13639 True False False \n", + "276176 6305 Q6DWJ6 True False False \n", + "276177 643961 Q9GZU1 True False False \n", + "276178 448457 Q13258 True False False \n", + "\n", + " consensus_direction consensus_stimulation consensus_inhibition \\\n", + "0 True False True \n", + "1 True False True \n", + "2 True False True \n", + "3 True True False \n", + "4 True True False \n", + "... ... ... ... \n", + "276174 False False False \n", + "276175 False False False \n", + "276176 False False False \n", + "276177 False False False \n", + "276178 False False False \n", + "\n", + " curation_effort references \\\n", + "0 3 TRIP:11290752;TRIP:11983166;TRIP:12601176 \n", + "1 3 TRIP:11290752;TRIP:11983166;TRIP:12601176 \n", + "2 3 TRIP:11290752;TRIP:11983166;TRIP:12601176 \n", + "3 13 DIP:19897728;HPRD:12732636;IntAct:19897728;Lit... \n", + "4 1 TRIP:18261457 \n", + "... ... ... \n", + "276174 3 Cellinker:10433504;Cellinker:7651358;Cellinker... \n", + "276175 10 Cellinker:10646498;Cellinker:10683202;Cellinke... \n", + "276176 1 Cellinker:26349500 \n", + "276177 1 Cellinker:20802798 \n", + "276178 4 Cellinker:10448933;Cellinker:16604093;Cellinke... \n", + "\n", + " sources type n_sources \\\n", + "0 TRIP post_translational 1 \n", + "1 TRIP post_translational 1 \n", + "2 TRIP post_translational 1 \n", + "3 DIP;HPRD;IntAct;Lit-BM-17;TRIP post_translational 5 \n", + "4 TRIP post_translational 1 \n", + "... ... ... ... \n", + "276174 Cellinker;Guide2Pharma_Cellinker small_molecule_protein 2 \n", + "276175 Cellinker;Guide2Pharma_Cellinker small_molecule_protein 2 \n", + "276176 Cellinker;Guide2Pharma_Cellinker small_molecule_protein 2 \n", + "276177 Cellinker;Guide2Pharma_Cellinker small_molecule_protein 2 \n", + "276178 Cellinker;Guide2Pharma_Cellinker small_molecule_protein 2 \n", + "\n", + " n_primary_sources n_references \\\n", + "0 1 3 \n", + "1 1 3 \n", + "2 1 3 \n", + "3 5 8 \n", + "4 1 1 \n", + "... ... ... \n", + "276174 1 3 \n", + "276175 1 10 \n", + "276176 1 1 \n", + "276177 1 1 \n", + "276178 1 4 \n", + "\n", + " references_stripped \n", + "0 11290752;11983166;12601176 \n", + "1 11290752;11983166;12601176 \n", + "2 11290752;11983166;12601176 \n", + "3 10980191;12732636;14551243;16822931;18430726;1... \n", + "4 18261457 \n", + "... ... \n", + "276174 10433504;7651358;8564227 \n", + "276175 10646498;10683202;10821780;11030734;11218067;1... \n", + "276176 26349500 \n", + "276177 20802798 \n", + "276178 10448933;16604093;7642548;9579725 \n", + "\n", + "[276179 rows x 16 columns]" + ] + }, + "execution_count": 12, + "metadata": {}, + "output_type": "execute_result" + } + ], + "source": [ + "resources.interactions" + ] + }, + { + "cell_type": "markdown", + "id": "d3dca809", + "metadata": {}, + "source": [ + "### Now we can explore another database we are interested in, for example, the ligand receptor one" + ] + }, + { + "cell_type": "code", + "execution_count": 13, + "id": "829de33a", + "metadata": {}, + "outputs": [], + "source": [ + "extra = op.interactions.LigRecExtra.get()" + ] + }, + { + "cell_type": "markdown", + "id": "fc585a3c", + "metadata": {}, + "source": [ + "### And then we add it to the Resources object" + ] + }, + { + "cell_type": "code", + "execution_count": 14, + "id": "91ae2cef", + "metadata": {}, + "outputs": [], + "source": [ + "resources.add_database(extra, reset_index=True)" + ] + }, + { + "cell_type": "markdown", + "id": "0e6e1986", + "metadata": {}, + "source": [ + "### Now we create the network with a similar list of genes but specifying the Resource object" + ] + }, + { + "cell_type": "code", + "execution_count": 15, + "id": "7401c535", + "metadata": {}, + "outputs": [], + "source": [ + "genes = [\"SRC\", \"NOTCH1\", \"PTK2\", \"CDH1\", \"CDH2\", \"VIM\", \"MAP4K4\", \"PTK2B\", \"COL1A1\"]" + ] + }, + { + "cell_type": "code", + "execution_count": 17, + "id": "60fcff6d", + "metadata": {}, + "outputs": [ + { + "name": "stdout", + "output_type": "stream", + "text": [ + "CPU times: user 22.9 ms, sys: 3.98 ms, total: 26.9 ms\n", + "Wall time: 25.7 ms\n" + ] + } + ], + "source": [ + "%%time\n", + "new_net1 = Network(genes, resources=resources.interactions)" + ] + }, + { + "cell_type": "code", + "execution_count": 18, + "id": "370180cc", + "metadata": {}, + "outputs": [ + { + "name": "stdout", + "output_type": "stream", + "text": [ + "P12931 Q05397\n", + "P12830 P12931\n", + "P12931 P19022\n", + "P12931 Q14289\n", + "P02452 P12931\n", + "P46531 P19022\n", + "P46531 P02452\n", + "Q14289 Q05397\n", + "CPU times: user 1.34 s, sys: 19.9 ms, total: 1.36 s\n", + "Wall time: 1.36 s\n" + ] + } + ], + "source": [ + "%%time\n", + "new_net1.connect_nodes(only_signed=True, consensus_only=True)" + ] + }, + { + "cell_type": "code", + "execution_count": 19, + "id": "8ffecf5c", + "metadata": {}, + "outputs": [ + { + "name": "stdout", + "output_type": "stream", + "text": [ + "looking for paths in the network with length: 0 for node SRC and NOTCH1\n", + "looking for paths in the network with length: 1 for node SRC and NOTCH1\n", + "looking for paths in the network with length: 2 for node SRC and NOTCH1\n", + "Found a path!\n", + "[['SRC', 'COL1A1', 'NOTCH1']]\n", + "looking for paths in the network with length: 0 for node SRC and PTK2\n", + "looking for paths in the network with length: 1 for node SRC and PTK2\n", + "Found a path!\n", + "[['SRC', 'PTK2']]\n", + "looking for paths in the network with length: 0 for node SRC and CDH1\n", + "looking for paths in the network with length: 1 for node SRC and CDH1\n", + "Found a path!\n", + "[['SRC', 'CDH1']]\n", + "looking for paths in the network with length: 0 for node SRC and CDH2\n", + "looking for paths in the network with length: 1 for node SRC and CDH2\n", + "Found a path!\n", + "[['SRC', 'CDH2']]\n", + "looking for paths in the network with length: 0 for node SRC and VIM\n", + "looking for paths in the network with length: 1 for node SRC and VIM\n", + "looking for paths in the network with length: 2 for node SRC and VIM\n", + "looking for paths in the network with length: 3 for node SRC and VIM\n", + "i_search = 3\n", + "Looking for paths with length: 0 for node SRC and VIM\n", + "i_search = 3\n", + "Looking for paths with length: 1 for node SRC and VIM\n", + "i_search = 3\n", + "Looking for paths with length: 2 for node SRC and VIM\n", + "[['SRC', 'TCF7L2', 'VIM'], ['SRC', 'NFKB1', 'VIM'], ['SRC', 'HNF4A', 'VIM'], ['SRC', 'HIPK2', 'VIM'], ['SRC', 'STAT5A', 'VIM']]\n", + "P12931 Q9NQB0\n", + "Q9NQB0 P08670\n", + "P12931 P19838\n", + "P19838 P08670\n", + "P12931 P41235\n", + "P41235 P08670\n", + "P12931 Q9H2X6\n", + "Q9H2X6 P08670\n", + "P12931 P42229\n", + "P42229 P08670\n", + "P12931 Q05397\n", + "P12830 P12931\n", + "P12931 P19022\n", + "P12931 Q14289\n", + "P02452 P12931\n", + "P12931 Q9NQB0\n", + "P12931 P19838\n", + "P12931 P41235\n", + "P41235 P12931\n", + "P12931 Q9H2X6\n", + "P12931 P42229\n", + "P46531 P19022\n", + "P46531 P02452\n", + "P46531 P19838\n", + "Q14289 Q05397\n", + "Q9NQB0 P08670\n", + "P19838 P08670\n", + "P41235 P08670\n", + "Q9H2X6 P08670\n", + "P42229 P08670\n", + "P19838 P02452\n", + "P41235 Q9NQB0\n", + "P19838 P42229\n", + "looking for paths in the network with length: 0 for node SRC and MAP4K4\n", + "looking for paths in the network with length: 1 for node SRC and MAP4K4\n", + "looking for paths in the network with length: 2 for node SRC and MAP4K4\n", + "looking for paths in the network with length: 3 for node SRC and MAP4K4\n", + "i_search = 3\n", + "Looking for paths with length: 0 for node SRC and MAP4K4\n", + "i_search = 3\n", + "Looking for paths with length: 1 for node SRC and MAP4K4\n", + "i_search = 3\n", + "Looking for paths with length: 2 for node SRC and MAP4K4\n", + "[['SRC', 'EPHB1', 'MAP4K4'], ['SRC', 'PPARG', 'MAP4K4']]\n", + "P12931 P54762\n", + "P54762 O95819\n", + "P12931 P37231\n", + "P37231 O95819\n", + "P12931 Q05397\n", + "P12830 P12931\n", + "P12931 P19022\n", + "P12931 Q14289\n", + "P02452 P12931\n", + "P12931 Q9NQB0\n", + "P12931 P19838\n", + "P12931 P41235\n", + "P41235 P12931\n", + "P12931 Q9H2X6\n", + "P12931 P42229\n", + "P12931 P54762\n", + "P54762 P12931\n", + "P12931 P37231\n", + "P46531 P19022\n", + "P46531 P02452\n", + "P46531 P19838\n", + "P46531 P37231\n", + "Q14289 Q05397\n", + "P54762 Q05397\n", + "P37231 P12830\n", + "P37231 P19022\n", + "Q9NQB0 P08670\n", + "P19838 P08670\n", + "P41235 P08670\n", + "Q9H2X6 P08670\n", + "P42229 P08670\n", + "P54762 O95819\n", + "P37231 O95819\n", + "P19838 P02452\n", + "P41235 Q9NQB0\n", + "P19838 P42229\n", + "P37231 P19838\n", + "P37231 P42229\n", + "looking for paths in the network with length: 0 for node SRC and PTK2B\n", + "looking for paths in the network with length: 1 for node SRC and PTK2B\n", + "Found a path!\n", + "[['SRC', 'PTK2B']]\n", + "looking for paths in the network with length: 0 for node SRC and COL1A1\n", + "looking for paths in the network with length: 1 for node SRC and COL1A1\n", + "Found a path!\n", + "[['SRC', 'COL1A1']]\n", + "looking for paths in the network with length: 0 for node NOTCH1 and PTK2\n", + "looking for paths in the network with length: 1 for node NOTCH1 and PTK2\n", + "looking for paths in the network with length: 2 for node NOTCH1 and PTK2\n", + "looking for paths in the network with length: 3 for node NOTCH1 and PTK2\n", + "Found a path!\n", + "[['NOTCH1', 'COL1A1', 'SRC', 'PTK2']]\n", + "looking for paths in the network with length: 0 for node NOTCH1 and CDH1\n", + "looking for paths in the network with length: 1 for node NOTCH1 and CDH1\n", + "looking for paths in the network with length: 2 for node NOTCH1 and CDH1\n", + "Found a path!\n", + "[['NOTCH1', 'PPARG', 'CDH1']]\n", + "looking for paths in the network with length: 0 for node NOTCH1 and CDH2\n", + "looking for paths in the network with length: 1 for node NOTCH1 and CDH2\n", + "Found a path!\n", + "[['NOTCH1', 'CDH2']]\n", + "looking for paths in the network with length: 0 for node NOTCH1 and VIM\n", + "looking for paths in the network with length: 1 for node NOTCH1 and VIM\n", + "looking for paths in the network with length: 2 for node NOTCH1 and VIM\n", + "Found a path!\n", + "[['NOTCH1', 'NFKB1', 'VIM']]\n", + "looking for paths in the network with length: 0 for node NOTCH1 and MAP4K4\n", + "looking for paths in the network with length: 1 for node NOTCH1 and MAP4K4\n", + "looking for paths in the network with length: 2 for node NOTCH1 and MAP4K4\n", + "Found a path!\n", + "[['NOTCH1', 'PPARG', 'MAP4K4']]\n", + "looking for paths in the network with length: 0 for node NOTCH1 and PTK2B\n", + "looking for paths in the network with length: 1 for node NOTCH1 and PTK2B\n", + "looking for paths in the network with length: 2 for node NOTCH1 and PTK2B\n", + "looking for paths in the network with length: 3 for node NOTCH1 and PTK2B\n", + "Found a path!\n", + "[['NOTCH1', 'COL1A1', 'SRC', 'PTK2B']]\n", + "looking for paths in the network with length: 0 for node NOTCH1 and COL1A1\n", + "looking for paths in the network with length: 1 for node NOTCH1 and COL1A1\n", + "Found a path!\n", + "[['NOTCH1', 'COL1A1']]\n", + "looking for paths in the network with length: 0 for node PTK2 and CDH1\n", + "looking for paths in the network with length: 1 for node PTK2 and CDH1\n", + "looking for paths in the network with length: 2 for node PTK2 and CDH1\n", + "Found a path!\n", + "[['PTK2', 'SRC', 'CDH1']]\n", + "looking for paths in the network with length: 0 for node PTK2 and CDH2\n", + "looking for paths in the network with length: 1 for node PTK2 and CDH2\n", + "looking for paths in the network with length: 2 for node PTK2 and CDH2\n", + "looking for paths in the network with length: 3 for node PTK2 and CDH2\n", + "i_search = 3\n", + "Looking for paths with length: 0 for node PTK2 and CDH2\n", + "i_search = 3\n", + "Looking for paths with length: 1 for node PTK2 and CDH2\n", + "i_search = 3\n", + "Looking for paths with length: 2 for node PTK2 and CDH2\n", + "i_search = 3\n", + "Looking for paths with length: 3 for node PTK2 and CDH2\n", + "[['PTK2', 'ZYX', 'SRC', 'CDH2'], ['PTK2', 'STAT1', 'SMAD7', 'CDH2'], ['PTK2', 'STAT1', 'ABL1', 'CDH2'], ['PTK2', 'STAT1', 'JUN', 'CDH2'], ['PTK2', 'STAT1', 'MYC', 'CDH2'], ['PTK2', 'STAT1', 'COMPLEX:P19838_Q04206', 'CDH2'], ['PTK2', 'STAT1', 'WT1', 'CDH2'], ['PTK2', 'STAT1', 'MET', 'CDH2'], ['PTK2', 'ACTN3', 'SRC', 'CDH2'], ['PTK2', 'PIK3CG', 'AR', 'CDH2'], ['PTK2', 'MITF', 'MET', 'CDH2'], ['PTK2', 'MITF', 'PAX6', 'CDH2'], ['PTK2', 'IL6', 'MET', 'CDH2'], ['PTK2', 'CDC42', 'CTNND1', 'CDH2'], ['PTK2', 'ASAP1', 'AR', 'CDH2'], ['PTK2', 'RAP1B', 'CTNND1', 'CDH2'], ['PTK2', 'SMAD4', 'MSX1', 'CDH2'], ['PTK2', 'SMAD4', 'PPARG', 'CDH2'], ['PTK2', 'SMAD4', 'MYC', 'CDH2'], ['PTK2', 'SMAD4', 'SMAD7', 'CDH2'], ['PTK2', 'SMAD4', 'SOX9', 'CDH2'], ['PTK2', 'SMAD4', 'MET', 'CDH2'], ['PTK2', 'SMAD4', 'MMP2', 'CDH2'], ['PTK2', 'ITGB4', 'SRC', 'CDH2'], ['PTK2', 'ACTN4', 'SRC', 'CDH2'], ['PTK2', 'PTPN13', 'SRC', 'CDH2'], ['PTK2', 'PTPN13', 'MET', 'CDH2'], ['PTK2', 'TXN', 'PTPN1', 'CDH2'], ['PTK2', 'MAPK12', 'JUN', 'CDH2'], ['PTK2', 'MAPK12', 'MYC', 'CDH2'], ['PTK2', 'NCOA1', 'SRC', 'CDH2'], ['PTK2', 'NCOA1', 'STAT3', 'CDH2'], ['PTK2', 'NCOA1', 'PAWR', 'CDH2'], ['PTK2', 'NCOA1', 'MMP2', 'CDH2'], ['PTK2', 'ROCK1', 'RAC1', 'CDH2'], ['PTK2', 'ROCK1', 'CTNNB1', 'CDH2'], ['PTK2', 'MYCN', 'CTNNB1', 'CDH2'], ['PTK2', 'CEBPA', 'CTNNB1', 'CDH2'], ['PTK2', 'PIK3CB', 'PIK3R1', 'CDH2'], ['PTK2', 'PIK3CB', 'RHOA', 'CDH2'], ['PTK2', 'CAPN2', 'CTNNB1', 'CDH2'], ['PTK2', 'EPHB2', 'CTNNB1', 'CDH2'], ['PTK2', 'PIK3R5', 'RAC1', 'CDH2'], ['PTK2', 'CASP7', 'CTNNB1', 'CDH2'], ['PTK2', 'CDK5', 'RAC1', 'CDH2'], ['PTK2', 'ECM1', 'RAC1', 'CDH2'], ['PTK2', 'ECM1', 'CTNNB1', 'CDH2'], ['PTK2', 'KDR', 'RAC1', 'CDH2'], ['PTK2', 'SOS1', 'PIK3CA', 'CDH2'], ['PTK2', 'SOS1', 'RHOA', 'CDH2'], ['PTK2', 'VEGFA', 'RAC1', 'CDH2'], ['PTK2', 'VEGFA', 'CTNNB1', 'CDH2'], ['PTK2', 'ITGA4', 'RHOA', 'CDH2'], ['PTK2', 'EGFR', 'CDC42', 'CDH2'], ['PTK2', 'SDC4', 'MMP9', 'CDH2'], ['PTK2', 'PECAM1', 'FER', 'CDH2'], ['PTK2', 'PPARD', 'CTNNB1', 'CDH2'], ['PTK2', 'PIK3CG', 'PIK3R1', 'CDH2'], ['PTK2', 'RPS6KB1', 'PIK3R1', 'CDH2'], ['PTK2', 'PIK3R3', 'RAC1', 'CDH2'], ['PTK2', 'EFNA1', 'CTNNB1', 'CDH2'], ['PTK2', 'CASP3', 'CTNNB1', 'CDH2'], ['PTK2', 'PIK3CD', 'PIK3R1', 'CDH2'], ['PTK2', 'PIK3CD', 'RAC1', 'CDH2'], ['PTK2', 'CXCL12', 'CTNNB1', 'CDH2']]\n", + "Q05397 Q15942\n", + "Q15942 P12931\n", + "P12931 P19022\n", + "Q05397 P42224\n", + "P42224 O15105\n", + "O15105 P19022\n", + "Q05397 P42224\n", + "P42224 P00519\n", + "P00519 P19022\n", + "Q05397 P42224\n", + "P42224 P05412\n", + "P05412 P19022\n", + "Q05397 P42224\n", + "P42224 P01106\n", + "P01106 P19022\n", + "Q05397 P42224\n", + "P42224 COMPLEX:P19838_Q04206\n", + "COMPLEX:P19838_Q04206 P19022\n", + "Q05397 P42224\n", + "P42224 P19544\n", + "P19544 P19022\n", + "Q05397 P42224\n", + "P42224 P08581\n", + "P08581 P19022\n", + "Q05397 Q08043\n", + "Q08043 P12931\n", + "P12931 P19022\n", + "Q05397 P48736\n", + "P48736 P10275\n", + "P10275 P19022\n", + "Q05397 O75030\n", + "O75030 P08581\n", + "P08581 P19022\n", + "Q05397 O75030\n", + "O75030 P26367\n", + "P26367 P19022\n", + "Q05397 P05231\n", + "P05231 P08581\n", + "P08581 P19022\n", + "Q05397 P60953\n", + "P60953 O60716\n", + "O60716 P19022\n", + "Q05397 Q9ULH1\n", + "Q9ULH1 P10275\n", + "P10275 P19022\n", + "Q05397 P61224\n", + "P61224 O60716\n", + "O60716 P19022\n", + "Q05397 Q13485\n", + "Q13485 P28360\n", + "P28360 P19022\n", + "Q05397 Q13485\n", + "Q13485 P37231\n", + "P37231 P19022\n", + "Q05397 Q13485\n", + "Q13485 P01106\n", + "P01106 P19022\n", + "Q05397 Q13485\n", + "Q13485 O15105\n", + "O15105 P19022\n", + "Q05397 Q13485\n", + "Q13485 P48436\n", + "P48436 P19022\n", + "Q05397 Q13485\n", + "Q13485 P08581\n", + "P08581 P19022\n", + "Q05397 Q13485\n", + "Q13485 P08253\n", + "P08253 P19022\n", + "Q05397 P16144\n", + "P16144 P12931\n", + "P12931 P19022\n", + "Q05397 O43707\n", + "O43707 P12931\n", + "P12931 P19022\n", + "Q05397 Q12923\n", + "Q12923 P12931\n", + "P12931 P19022\n", + "Q05397 Q12923\n", + "Q12923 P08581\n", + "P08581 P19022\n", + "Q05397 P10599\n", + "P10599 P18031\n", + "P18031 P19022\n", + "Q05397 P53778\n", + "P53778 P05412\n", + "P05412 P19022\n", + "Q05397 P53778\n", + "P53778 P01106\n", + "P01106 P19022\n", + "Q05397 Q15788\n", + "Q15788 P12931\n", + "P12931 P19022\n", + "Q05397 Q15788\n", + "Q15788 P40763\n", + "P40763 P19022\n", + "Q05397 Q15788\n", + "Q15788 Q96IZ0\n", + "Q96IZ0 P19022\n", + "Q05397 Q15788\n", + "Q15788 P08253\n", + "P08253 P19022\n", + "Q13464 Q05397\n", + "P63000 Q13464\n", + "P19022 P63000\n", + "Q13464 Q05397\n", + "Q13464 P35222\n", + "P19022 P35222\n", + "P04198 Q05397\n", + "P35222 P04198\n", + "P19022 P35222\n", + "P49715 Q05397\n", + "P35222 P49715\n", + "P19022 P35222\n", + "Q05397 P42338\n", + "P27986 P42338\n", + "P19022 P27986\n", + "Q05397 P42338\n", + "P61586 P42338\n", + "P19022 P61586\n", + "P17655 Q05397\n", + "P35222 P17655\n", + "P19022 P35222\n", + "P29323 Q05397\n", + "P35222 P29323\n", + "P19022 P35222\n", + "Q05397 Q8WYR1\n", + "Q8WYR1 P63000\n", + "P19022 P63000\n", + "P55210 Q05397\n", + "P35222 P55210\n", + "P19022 P35222\n", + "Q00535 Q05397\n", + "P63000 Q00535\n", + "P19022 P63000\n", + "Q16610 Q05397\n", + "P63000 Q16610\n", + "P19022 P63000\n", + "Q16610 Q05397\n", + "P35222 Q16610\n", + "P19022 P35222\n", + "P35968 Q05397\n", + "P63000 P35968\n", + "P19022 P63000\n", + "Q07889 Q05397\n", + "Q07889 P42336\n", + "P19022 P42336\n", + "Q07889 Q05397\n", + "P61586 Q07889\n", + "P19022 P61586\n", + "P15692 Q05397\n", + "P15692 P63000\n", + "P19022 P63000\n", + "P15692 Q05397\n", + "P35222 P15692\n", + "P19022 P35222\n", + "P13612 Q05397\n", + "P61586 P13612\n", + "P19022 P61586\n", + "P00533 Q05397\n", + "P60953 P00533\n", + "P19022 P60953\n", + "P31431 Q05397\n", + "P14780 P31431\n", + "P19022 P14780\n", + "P16284 Q05397\n", + "P16591 P16284\n", + "P19022 P16591\n", + "Q03181 Q05397\n", + "P35222 Q03181\n", + "P19022 P35222\n", + "Q05397 P48736\n", + "P27986 P48736\n", + "P19022 P27986\n", + "P23443 Q05397\n", + "P23443 P27986\n", + "P19022 P27986\n", + "Q05397 Q92569\n", + "Q92569 P63000\n", + "P19022 P63000\n", + "P20827 Q05397\n", + "P35222 P20827\n", + "P19022 P35222\n", + "P42574 Q05397\n", + "P42574 P35222\n", + "P19022 P35222\n", + "Q05397 O00329\n", + "P27986 O00329\n", + "P19022 P27986\n", + "Q05397 O00329\n", + "O00329 P63000\n", + "P19022 P63000\n", + "P48061 Q05397\n", + "P35222 P48061\n", + "P19022 P35222\n", + "P12931 Q05397\n", + "P12830 P12931\n", + "P12931 P19022\n", + "P12931 Q14289\n", + "P02452 P12931\n", + "P12931 Q9NQB0\n", + "P12931 P19838\n", + "P12931 P41235\n", + "P41235 P12931\n", + "P12931 Q9H2X6\n", + "P12931 P42229\n", + "P12931 P54762\n", + "P54762 P12931\n", + "P12931 P37231\n", + "Q15942 P12931\n", + "P12931 P42224\n", + "P12931 P00519\n", + "P05412 P12931\n", + "COMPLEX:P19838_Q04206 P12931\n", + "P12931 P08581\n", + "Q08043 P12931\n", + "P12931 P10275\n", + "P10275 P12931\n", + "P12931 P60953\n", + "P12931 O60716\n", + "P12931 Q9ULH1\n", + "P12931 P08253\n", + "P12931 P16144\n", + "P16144 P12931\n", + "O43707 P12931\n", + "Q12923 P12931\n", + "P18031 P12931\n", + "Q15788 P12931\n", + "P12931 P40763\n", + "P12931 P63000\n", + "P12931 P35222\n", + "P12931 P42338\n", + "P12931 P61586\n", + "P17655 P12931\n", + "P29323 P12931\n", + "P12931 Q8WYR1\n", + "Q00535 P12931\n", + "P12931 P35968\n", + "P12931 Q07889\n", + "P12931 P42336\n", + "P15692 P12931\n", + "P13612 P12931\n", + "P12931 P00533\n", + "P12931 P14780\n", + "P12931 P16284\n", + "P12931 Q92569\n", + "P12931 P20827\n", + "P12931 O00329\n", + "P46531 P19022\n", + "P46531 P02452\n", + "P46531 P19838\n", + "P46531 P37231\n", + "P46531 P05412\n", + "P46531 P01106\n", + "COMPLEX:P19838_Q04206 P46531\n", + "P10275 P46531\n", + "P26367 P46531\n", + "P46531 P48436\n", + "P40763 P46531\n", + "P35222 P46531\n", + "P46531 P15692\n", + "P46531 P00533\n", + "P46531 P42574\n", + "Q14289 Q05397\n", + "P54762 Q05397\n", + "Q05397 Q15942\n", + "Q05397 P42224\n", + "COMPLEX:P19838_Q04206 Q05397\n", + "P08581 Q05397\n", + "Q05397 Q08043\n", + "Q05397 P48736\n", + "P48736 Q05397\n", + "Q05397 O75030\n", + "Q05397 P05231\n", + "Q05397 P60953\n", + "Q05397 Q9ULH1\n", + "Q05397 P61224\n", + "Q05397 Q13485\n", + "Q05397 P16144\n", + "P16144 Q05397\n", + "Q05397 O43707\n", + "Q05397 Q12923\n", + "Q05397 P10599\n", + "P18031 Q05397\n", + "Q05397 P53778\n", + "Q05397 Q15788\n", + "Q15788 Q05397\n", + "Q13464 Q05397\n", + "Q05397 P63000\n", + "P04198 Q05397\n", + "P49715 Q05397\n", + "Q05397 P42338\n", + "P42338 Q05397\n", + "Q05397 P27986\n", + 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"P40763 P14780\n", + "P16591 P40763\n", + "P40763 P42574\n", + "P40763 P48061\n", + "P48061 P40763\n", + "P63000 Q13464\n", + "Q13464 P35222\n", + "P35222 Q13464\n", + "P61586 Q13464\n", + "P42574 Q13464\n", + "P48061 Q13464\n", + "P63000 P35222\n", + "P63000 P42338\n", + "P27986 P63000\n", + "P63000 P61586\n", + "P29323 P63000\n", + "P63000 Q8WYR1\n", + "Q8WYR1 P63000\n", + "P63000 Q00535\n", + "P63000 Q16610\n", + "P63000 P35968\n", + "Q07889 P63000\n", + "P63000 P42336\n", + "P42336 P63000\n", + "P63000 P15692\n", + "P15692 P63000\n", + "P13612 P63000\n", + "P00533 P63000\n", + "P31431 P63000\n", + "P63000 Q92569\n", + "Q92569 P63000\n", + "P20827 P63000\n", + "P63000 O00329\n", + "O00329 P63000\n", + "P48061 P63000\n", + "P35222 P04198\n", + "P35222 P49715\n", + "P35222 P27986\n", + "P35222 P61586\n", + "P35222 P17655\n", + "P35222 P29323\n", + "P35222 P55210\n", + "P35222 Q16610\n", + "P35222 P42336\n", + "P35222 P15692\n", + "P00533 P35222\n", + "P35222 P14780\n", + "P16591 P35222\n", + "P35222 Q03181\n", + "P35222 P20827\n", + "P35222 P42574\n", + "P42574 P35222\n", + "P35222 P48061\n", + "P04198 P00533\n", + "Q03181 P49715\n", + "P27986 P42338\n", + "P61586 P42338\n", + "P35968 P42338\n", + "P42338 Q07889\n", + "P00533 P42338\n", + "Q92569 P42338\n", + "P48061 P42338\n", + "P27986 P61586\n", + "P61586 P27986\n", + "P29323 P27986\n", + "P35968 P27986\n", + "P27986 Q07889\n", + "P15692 P27986\n", + "P00533 P27986\n", + "P27986 P23443\n", + "P23443 P27986\n", + "P27986 O00329\n", + "P48061 P27986\n", + "P17655 P61586\n", + "P61586 Q07889\n", + "P61586 P42336\n", + "P42336 P61586\n", + "P61586 P13612\n", + "P00533 P61586\n", + "P61586 P14780\n", + "P20827 P61586\n", + "P42574 P61586\n", + "P29323 P42336\n", + "P48061 P29323\n", + "P35968 Q8WYR1\n", + "P00533 Q8WYR1\n", + "P48061 Q8WYR1\n", + "P42574 P55210\n", + "P35968 Q07889\n", + "P35968 P42336\n", + "P15692 P35968\n", + "P35968 P16284\n", + "P35968 Q92569\n", + "P35968 O00329\n", + "Q07889 P42336\n", + "P42336 Q07889\n", + "P15692 Q07889\n", + "P00533 Q07889\n", + "Q92569 Q07889\n", + "O00329 Q07889\n", + "P15692 P42336\n", + "P00533 P42336\n", + "P42336 P23443\n", + "Q92569 P42336\n", + "P48061 P42336\n", + "P15692 P00533\n", + "P15692 P14780\n", + "P00533 P14780\n", + "P00533 Q92569\n", + "P00533 O00329\n", + "P14780 P31431\n", + "Q03181 P14780\n", + "P23443 P14780\n", + "P48061 P14780\n", + "P16591 P16284\n", + "P48061 Q92569\n", + "P48061 O00329\n", + "looking for paths in the network with length: 0 for node PTK2 and VIM\n", + "looking for paths in the network with length: 1 for node PTK2 and VIM\n", + "looking for paths in the network with length: 2 for node PTK2 and VIM\n", + "looking for paths in the network with length: 3 for node PTK2 and VIM\n", + "Found a path!\n", + "[['PTK2', 'MAPK12', 'JUN', 'VIM'], ['PTK2', 'PIK3R1', 'STAT3', 'VIM'], ['PTK2', 'PIK3R1', 'NFKB1', 'VIM'], ['PTK2', 'IL6', 'STAT3', 'VIM'], ['PTK2', 'CDC42', 'CTNNB1', 'VIM'], ['PTK2', 'NCOA1', 'STAT5A', 'VIM'], ['PTK2', 'NCOA1', 'STAT3', 'VIM'], ['PTK2', 'NCOA1', 'PAWR', 'VIM'], ['PTK2', 'RAC1', 'ROCK1', 'VIM'], ['PTK2', 'RAC1', 'NFKB1', 'VIM'], ['PTK2', 'RAC1', 'STAT3', 'VIM'], ['PTK2', 'RAC1', 'CTNNB1', 'VIM'], ['PTK2', 'RAP1B', 'CTNNB1', 'VIM'], ['PTK2', 'SMAD4', 'TCF7L2', 'VIM'], ['PTK2', 'PIK3CA', 'STAT3', 'VIM'], ['PTK2', 'PIK3CA', 'NFKB1', 'VIM'], ['PTK2', 'STAT1', 'JUN', 'VIM'], ['PTK2', 'STAT1', 'COMPLEX:P19838_Q04206', 'VIM'], ['PTK2', 'TXN', 'NFKB1', 'VIM']]\n", + "looking for paths in the network with length: 0 for node PTK2 and MAP4K4\n", + "looking for paths in the network with length: 1 for node PTK2 and MAP4K4\n", + "looking for paths in the network with length: 2 for node PTK2 and MAP4K4\n", + "looking for paths in the network with length: 3 for node PTK2 and MAP4K4\n", + "Found a path!\n", + "[['PTK2', 'PTPN13', 'EPHB1', 'MAP4K4'], ['PTK2', 'PTPN13', 'EPHB2', 'MAP4K4'], ['PTK2', 'SMAD4', 'PPARG', 'MAP4K4']]\n", + "looking for paths in the network with length: 0 for node PTK2 and PTK2B\n", + "looking for paths in the network with length: 1 for node PTK2 and PTK2B\n", + "Found a path!\n", + "[['PTK2', 'PTK2B']]\n", + "looking for paths in the network with length: 0 for node PTK2 and COL1A1\n", + "looking for paths in the network with length: 1 for node PTK2 and COL1A1\n", + "looking for paths in the network with length: 2 for node PTK2 and COL1A1\n", + "Found a path!\n", + "[['PTK2', 'RAC1', 'COL1A1'], ['PTK2', 'SMAD4', 'COL1A1'], ['PTK2', 'SRC', 'COL1A1'], ['PTK2', 'CASP7', 'COL1A1'], ['PTK2', 'RHOA', 'COL1A1'], ['PTK2', 'ITGA4', 'COL1A1'], ['PTK2', 'SDC4', 'COL1A1'], ['PTK2', 'ITGB4', 'COL1A1'], ['PTK2', 'CASP3', 'COL1A1'], ['PTK2', 'SOS1', 'COL1A1']]\n", + "looking for paths in the network with length: 0 for node CDH1 and CDH2\n", + "looking for paths in the network with length: 1 for node CDH1 and CDH2\n", + "looking for paths in the network with length: 2 for node CDH1 and CDH2\n", + "Found a path!\n", + "[['CDH1', 'SRC', 'CDH2'], ['CDH1', 'RAC1', 'CDH2'], ['CDH1', 'CDC42', 'CDH2']]\n", + "looking for paths in the network with length: 0 for node CDH1 and VIM\n", + "looking for paths in the network with length: 1 for node CDH1 and VIM\n", + "looking for paths in the network with length: 2 for node CDH1 and VIM\n", + "Found a path!\n", + "[['CDH1', 'CTNNB1', 'VIM']]\n", + "looking for paths in the network with length: 0 for node CDH1 and MAP4K4\n", + "looking for paths in the network with length: 1 for node CDH1 and MAP4K4\n", + "looking for paths in the network with length: 2 for node CDH1 and MAP4K4\n", + "looking for paths in the network with length: 3 for node CDH1 and MAP4K4\n", + "Found a path!\n", + "[['CDH1', 'SRC', 'EPHB1', 'MAP4K4'], ['CDH1', 'SRC', 'PPARG', 'MAP4K4'], ['CDH1', 'CTNNB1', 'EPHB2', 'MAP4K4'], ['CDH1', 'CTNNB1', 'PPARG', 'MAP4K4']]\n", + "looking for paths in the network with length: 0 for node CDH1 and PTK2B\n", + "looking for paths in the network with length: 1 for node CDH1 and PTK2B\n", + "looking for paths in the network with length: 2 for node CDH1 and PTK2B\n", + "Found a path!\n", + "[['CDH1', 'SRC', 'PTK2B'], ['CDH1', 'PIK3CA', 'PTK2B'], ['CDH1', 'RAC1', 'PTK2B']]\n", + "looking for paths in the network with length: 0 for node CDH1 and COL1A1\n", + "looking for paths in the network with length: 1 for node CDH1 and COL1A1\n", + "looking for paths in the network with length: 2 for node CDH1 and COL1A1\n", + "Found a path!\n", + "[['CDH1', 'RAC1', 'COL1A1'], ['CDH1', 'RHOA', 'COL1A1']]\n", + "looking for paths in the network with length: 0 for node CDH2 and VIM\n", + "looking for paths in the network with length: 1 for node CDH2 and VIM\n", + "looking for paths in the network with length: 2 for node CDH2 and VIM\n", + "Found a path!\n", + "[['CDH2', 'CTNNB1', 'VIM']]\n", + "looking for paths in the network with length: 0 for node CDH2 and MAP4K4\n", + "looking for paths in the network with length: 1 for node CDH2 and MAP4K4\n", + "looking for paths in the network with length: 2 for node CDH2 and MAP4K4\n", + "looking for paths in the network with length: 3 for node CDH2 and MAP4K4\n", + "Found a path!\n", + "[['CDH2', 'CTNNB1', 'EPHB2', 'MAP4K4'], ['CDH2', 'CTNNB1', 'PPARG', 'MAP4K4']]\n", + "looking for paths in the network with length: 0 for node CDH2 and PTK2B\n", + "looking for paths in the network with length: 1 for node CDH2 and PTK2B\n", + "looking for paths in the network with length: 2 for node CDH2 and PTK2B\n", + "Found a path!\n", + "[['CDH2', 'PIK3CA', 'PTK2B'], ['CDH2', 'STAT3', 'PTK2B']]\n", + "looking for paths in the network with length: 0 for node CDH2 and COL1A1\n", + "looking for paths in the network with length: 1 for node CDH2 and COL1A1\n", + "looking for paths in the network with length: 2 for node CDH2 and COL1A1\n", + "Found a path!\n", + "[['CDH2', 'RAC1', 'COL1A1'], ['CDH2', 'RHOA', 'COL1A1'], ['CDH2', 'SRC', 'COL1A1']]\n", + "looking for paths in the network with length: 0 for node VIM and MAP4K4\n", + "looking for paths in the network with length: 1 for node VIM and MAP4K4\n", + "looking for paths in the network with length: 2 for node VIM and MAP4K4\n", + "looking for paths in the network with length: 3 for node VIM and MAP4K4\n", + "i_search = 3\n", + "Looking for paths with length: 0 for node VIM and MAP4K4\n", + "i_search = 3\n", + "Looking for paths with length: 1 for node VIM and MAP4K4\n", + "i_search = 3\n", + "Looking for paths with length: 2 for node VIM and MAP4K4\n", + "i_search = 3\n", + "Looking for paths with length: 3 for node VIM and MAP4K4\n", + "[['VIM', 'TGFB1', 'TNF', 'MAP4K4'], ['VIM', 'COMPLEX:P19838_Q04206', 'IKBKB', 'MAP4K4'], ['VIM', 'COMPLEX:P19838_Q04206', 'IKBKE', 'MAP4K4'], ['VIM', 'COMPLEX:P19838_Q04206', 'IKBKG', 'MAP4K4'], ['VIM', 'COMPLEX:P19838_Q04206', 'CHUK', 'MAP4K4'], ['VIM', 'TP63', 'IKBKB', 'MAP4K4'], ['VIM', 'AKT1', 'TNF', 'MAP4K4'], ['VIM', 'COMPLEX:Q04206_Q04864', 'IKBKE', 'MAP4K4'], ['VIM', 'COMPLEX:Q00653_Q01201', 'CHUK', 'MAP4K4'], ['VIM', 'MAPKAPK2', 'TNF', 'MAP4K4'], ['VIM', 'JUN', 'MAP3K3', 'MAP4K4'], ['VIM', 'CASP3', 'TNF', 'MAP4K4'], ['VIM', 'PLK1', 'MAP3K8', 'MAP4K4'], ['VIM', 'IRF6', 'TNF', 'MAP4K4'], ['VIM', 'NFKB1', 'IKBKG', 'MAP4K4'], ['VIM', 'NFKB1', 'MAP3K2', 'MAP4K4'], ['VIM', 'NFKB1', 'IKBKE', 'MAP4K4'], ['VIM', 'NFKB1', 'MAP3K3', 'MAP4K4']]\n", + "P01137 P08670\n", + "P01375 P01137\n", + "P01375 O95819\n", + "COMPLEX:P19838_Q04206 P08670\n", + "O14920 COMPLEX:P19838_Q04206\n", + "O95819 O14920\n", + "COMPLEX:P19838_Q04206 P08670\n", + "COMPLEX:P19838_Q04206 Q14164\n", + "O95819 Q14164\n", + "COMPLEX:P19838_Q04206 P08670\n", + "Q9Y6K9 COMPLEX:P19838_Q04206\n", + "O95819 Q9Y6K9\n", + "COMPLEX:P19838_Q04206 P08670\n", + "O15111 COMPLEX:P19838_Q04206\n", + "O95819 O15111\n", + "Q9H3D4 P08670\n", + "O14920 Q9H3D4\n", + "O95819 O14920\n", + "P31749 P08670\n", + "P01375 P31749\n", + "P01375 O95819\n", + "COMPLEX:Q04206_Q04864 P08670\n", + "COMPLEX:Q04206_Q04864 Q14164\n", + "O95819 Q14164\n", + "COMPLEX:Q00653_Q01201 P08670\n", + "O15111 COMPLEX:Q00653_Q01201\n", + "O95819 O15111\n", + "P49137 P08670\n", + "P01375 P49137\n", + "P01375 O95819\n", + "P05412 P08670\n", + "Q99759 P05412\n", + "O95819 Q99759\n", + "P42574 P08670\n", + "P01375 P42574\n", + "P01375 O95819\n", + "P53350 P08670\n", + "P41279 P53350\n", + "O95819 P41279\n", + "O14896 P08670\n", + "O14896 P01375\n", + "P01375 O95819\n", + "P19838 P08670\n", + "P19838 Q9Y6K9\n", + "O95819 Q9Y6K9\n", + "P19838 P08670\n", + "Q9Y2U5 P19838\n", + "O95819 Q9Y2U5\n", + "P19838 P08670\n", + "Q14164 P19838\n", + "O95819 Q14164\n", + "P19838 P08670\n", + "Q99759 P19838\n", + "O95819 Q99759\n", + "P12931 Q05397\n", + "P12830 P12931\n", + "P12931 P19022\n", + "P12931 Q14289\n", + "P02452 P12931\n", + "P12931 Q9NQB0\n", + "P12931 P19838\n", + "P12931 P41235\n", + "P41235 P12931\n", + "P12931 Q9H2X6\n", + "P12931 P42229\n", + "P12931 P54762\n", + "P54762 P12931\n", + "P12931 P37231\n", + "Q15942 P12931\n", + "P12931 P42224\n", + "P12931 P00519\n", + "P05412 P12931\n", + "COMPLEX:P19838_Q04206 P12931\n", + "P12931 P08581\n", + "Q08043 P12931\n", + "P12931 P10275\n", + "P10275 P12931\n", + "P12931 P60953\n", + "P12931 O60716\n", + "P12931 Q9ULH1\n", + "P12931 P08253\n", + "P12931 P16144\n", + "P16144 P12931\n", + "O43707 P12931\n", + "Q12923 P12931\n", + "P18031 P12931\n", + "Q15788 P12931\n", + "P12931 P40763\n", + "P12931 P63000\n", + "P12931 P35222\n", + "P12931 P42338\n", + "P12931 P61586\n", + "P17655 P12931\n", + "P29323 P12931\n", + "P12931 Q8WYR1\n", + "Q00535 P12931\n", + "P12931 P35968\n", + "P12931 Q07889\n", + "P12931 P42336\n", + "P15692 P12931\n", + "P13612 P12931\n", + "P12931 P00533\n", + "P12931 P14780\n", + "P12931 P16284\n", + "P12931 Q92569\n", + "P12931 P20827\n", + "P12931 O00329\n", + "P12931 O14920\n", + "P12931 O15111\n", + "P12931 P31749\n", + "COMPLEX:Q04206_Q04864 P12931\n", + "COMPLEX:Q00653_Q01201 P12931\n", + "P12931 Q9Y2U5\n", + "P46531 P19022\n", + "P46531 P02452\n", + "P46531 P19838\n", + "P46531 P37231\n", + "P46531 P05412\n", + "P46531 P01106\n", + "COMPLEX:P19838_Q04206 P46531\n", + "P10275 P46531\n", + "P26367 P46531\n", + "P46531 P48436\n", + "P40763 P46531\n", + "P35222 P46531\n", + "P46531 P15692\n", + "P46531 P00533\n", + "P46531 P42574\n", + "P46531 O15111\n", + "Q9H3D4 P46531\n", + "COMPLEX:Q04206_Q04864 P46531\n", + "COMPLEX:Q00653_Q01201 P46531\n", + "Q14289 Q05397\n", + "P54762 Q05397\n", + "Q05397 Q15942\n", + "Q05397 P42224\n", + "COMPLEX:P19838_Q04206 Q05397\n", + "P08581 Q05397\n", + "Q05397 Q08043\n", + "Q05397 P48736\n", + "P48736 Q05397\n", + "Q05397 O75030\n", + "Q05397 P05231\n", + "Q05397 P60953\n", + "Q05397 Q9ULH1\n", + "Q05397 P61224\n", + "Q05397 Q13485\n", + "Q05397 P16144\n", + "P16144 Q05397\n", + "Q05397 O43707\n", + "Q05397 Q12923\n", + "Q05397 P10599\n", + "P18031 Q05397\n", + "Q05397 P53778\n", + "Q05397 Q15788\n", + "Q15788 Q05397\n", + "Q13464 Q05397\n", + "Q05397 P63000\n", + "P04198 Q05397\n", + "P49715 Q05397\n", + "Q05397 P42338\n", + "P42338 Q05397\n", + "Q05397 P27986\n", + "P61586 Q05397\n", + "P17655 Q05397\n", + "P29323 Q05397\n", + "Q05397 Q8WYR1\n", + "Q8WYR1 Q05397\n", + "P55210 Q05397\n", + "Q00535 Q05397\n", + "Q16610 Q05397\n", + "P35968 Q05397\n", + "Q07889 Q05397\n", + "Q05397 P42336\n", + "P15692 Q05397\n", + "P13612 Q05397\n", + "P00533 Q05397\n", + "P31431 Q05397\n", + "P16284 Q05397\n", + "Q03181 Q05397\n", + "P23443 Q05397\n", + "Q05397 Q92569\n", + "Q92569 Q05397\n", + "P20827 Q05397\n", + "P42574 Q05397\n", + "Q05397 O00329\n", + "O00329 Q05397\n", + "P48061 Q05397\n", + "P01375 Q05397\n", + "COMPLEX:Q04206_Q04864 Q05397\n", + "COMPLEX:Q00653_Q01201 Q05397\n", + "P37231 P12830\n", + "P12830 Q15942\n", + "P05412 P12830\n", + "P01106 P12830\n", + "COMPLEX:P19838_Q04206 P12830\n", + "P19544 P12830\n", + "P08581 P12830\n", + "P10275 P12830\n", + "O75030 P12830\n", + "P60953 P12830\n", + "O60716 P12830\n", + "P61224 P12830\n", + "Q13485 P12830\n", + "P12830 P63000\n", + "P63000 P12830\n", + "P12830 P35222\n", + "P12830 P27986\n", + "P12830 P61586\n", + "P12830 P42336\n", + "P12830 P00533\n", + "P12830 P20827\n", + "Q9H3D4 P12830\n", + "COMPLEX:Q04206_Q04864 P12830\n", + "COMPLEX:Q00653_Q01201 P12830\n", + "P37231 P19022\n", + "O15105 P19022\n", + "P00519 P19022\n", + "P05412 P19022\n", + "P01106 P19022\n", + "COMPLEX:P19838_Q04206 P19022\n", + "P19544 P19022\n", + "P08581 P19022\n", + "P10275 P19022\n", + "P26367 P19022\n", + "P19022 P60953\n", + "O60716 P19022\n", + "P28360 P19022\n", + "P48436 P19022\n", + "P08253 P19022\n", + "P18031 P19022\n", + "P40763 P19022\n", + "Q96IZ0 P19022\n", + "P19022 P63000\n", + "P19022 P35222\n", + "P19022 P27986\n", + "P19022 P61586\n", + "Q00535 P19022\n", + "P19022 P42336\n", + "P19022 P14780\n", + "P19022 P16591\n", + "COMPLEX:Q04206_Q04864 P19022\n", + "COMPLEX:Q00653_Q01201 P19022\n", + "Q9NQB0 P08670\n", + "P19838 P08670\n", + "P41235 P08670\n", + "Q9H2X6 P08670\n", + "P42229 P08670\n", + "P05412 P08670\n", + "COMPLEX:P19838_Q04206 P08670\n", + "P40763 P08670\n", + "Q96IZ0 P08670\n", + "Q13464 P08670\n", + "P35222 P08670\n", + "P55210 P08670\n", + "P42574 P08670\n", + "P01137 P08670\n", + "Q9H3D4 P08670\n", + "P31749 P08670\n", + "COMPLEX:Q04206_Q04864 P08670\n", + "COMPLEX:Q00653_Q01201 P08670\n", + "P49137 P08670\n", + "P53350 P08670\n", + "O14896 P08670\n", + "P54762 O95819\n", + "P37231 O95819\n", + "P29323 O95819\n", + "O95819 P01375\n", + "P01375 O95819\n", + "O95819 O14920\n", + "O95819 Q14164\n", + "O95819 Q9Y6K9\n", + "O95819 O15111\n", + "O95819 Q99759\n", + "O95819 P41279\n", + "O95819 Q9Y2U5\n", + "Q14289 Q15942\n", + "P01106 Q14289\n", + "P48736 Q14289\n", + "Q14289 Q9ULH1\n", + "P61224 Q14289\n", + "Q14289 P10599\n", + "Q14289 P53778\n", + "Q14289 P40763\n", + "Q14289 P63000\n", + "P35968 Q14289\n", + "Q14289 Q07889\n", + "P42336 Q14289\n", + "P15692 Q14289\n", + "P13612 Q14289\n", + "Q14289 P00533\n", + "P19838 P02452\n", + "O15105 P02452\n", + "Q13485 P02452\n", + "P02452 P16144\n", + "P63000 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"P35222 P49715\n", + "P35222 P27986\n", + "P35222 P61586\n", + "P35222 P17655\n", + "P35222 P29323\n", + "P35222 P55210\n", + "P35222 Q16610\n", + "P35222 P42336\n", + "P35222 P15692\n", + "P00533 P35222\n", + "P35222 P14780\n", + "P16591 P35222\n", + "P35222 Q03181\n", + "P35222 P20827\n", + "P35222 P42574\n", + "P42574 P35222\n", + "P35222 P48061\n", + "P35222 Q9Y6K9\n", + "Q9H3D4 P35222\n", + "P35222 P31749\n", + "P31749 P35222\n", + "COMPLEX:Q04206_Q04864 P35222\n", + "COMPLEX:Q00653_Q01201 P35222\n", + "P04198 P00533\n", + "Q03181 P49715\n", + "P49715 P01375\n", + "COMPLEX:Q04206_Q04864 P49715\n", + "COMPLEX:Q00653_Q01201 P49715\n", + "P27986 P42338\n", + "P61586 P42338\n", + "P35968 P42338\n", + "P42338 Q07889\n", + "P00533 P42338\n", + "Q92569 P42338\n", + "P48061 P42338\n", + "P42338 P31749\n", + "P27986 P61586\n", + "P61586 P27986\n", + "P29323 P27986\n", + "P35968 P27986\n", + "P27986 Q07889\n", + "P15692 P27986\n", + "P00533 P27986\n", + "P27986 P23443\n", + "P23443 P27986\n", + "P27986 O00329\n", + "P48061 P27986\n", + "P01137 P27986\n", + "P27986 P31749\n", + "COMPLEX:Q04206_Q04864 P27986\n", + "COMPLEX:Q00653_Q01201 P27986\n", + "P17655 P61586\n", + "P61586 Q07889\n", + "P61586 P42336\n", + "P42336 P61586\n", + "P61586 P13612\n", + "P00533 P61586\n", + "P61586 P14780\n", + "P20827 P61586\n", + "P42574 P61586\n", + "P01375 P61586\n", + "P61586 P31749\n", + "P29323 P42336\n", + "P48061 P29323\n", + "P29323 P01137\n", + "P01137 P29323\n", + "COMPLEX:Q04206_Q04864 P29323\n", + "COMPLEX:Q00653_Q01201 P29323\n", + "P35968 Q8WYR1\n", + "P00533 Q8WYR1\n", + "P48061 Q8WYR1\n", + "Q8WYR1 P31749\n", + "P42574 P55210\n", + "COMPLEX:Q04206_Q04864 P55210\n", + "COMPLEX:Q00653_Q01201 P55210\n", + "P01137 Q16610\n", + "P35968 Q07889\n", + "P35968 P42336\n", + "P15692 P35968\n", + "P35968 P16284\n", + "P35968 Q92569\n", + "P35968 O00329\n", + "P35968 P31749\n", + "COMPLEX:Q04206_Q04864 P35968\n", + "COMPLEX:Q00653_Q01201 P35968\n", + "Q07889 P42336\n", + "P42336 Q07889\n", + "P15692 Q07889\n", + "P00533 Q07889\n", + "Q92569 Q07889\n", + "O00329 Q07889\n", + "Q07889 P31749\n", + "P15692 P42336\n", + "P00533 P42336\n", + "P42336 P23443\n", + "Q92569 P42336\n", + "P48061 P42336\n", + "P01137 P42336\n", + "P42336 P31749\n", + "COMPLEX:Q04206_Q04864 P42336\n", + "COMPLEX:Q00653_Q01201 P42336\n", + "P15692 P00533\n", + "P15692 P14780\n", + "P01137 P15692\n", + "Q9H3D4 P15692\n", + "COMPLEX:Q04206_Q04864 P15692\n", + "COMPLEX:Q00653_Q01201 P15692\n", + "P49137 P15692\n", + "P00533 P14780\n", + "P00533 Q92569\n", + "P00533 O00329\n", + "P01137 P00533\n", + "COMPLEX:Q04206_Q04864 P00533\n", + "COMPLEX:Q00653_Q01201 P00533\n", + "P14780 P31431\n", + "COMPLEX:Q04206_Q04864 P31431\n", + "COMPLEX:Q00653_Q01201 P31431\n", + "Q03181 P14780\n", + "P23443 P14780\n", + "P48061 P14780\n", + "P14780 P01137\n", + "P01375 P14780\n", + "COMPLEX:Q04206_Q04864 P14780\n", + "COMPLEX:Q00653_Q01201 P14780\n", + "P16591 P16284\n", + "COMPLEX:Q04206_Q04864 P16284\n", + "COMPLEX:Q00653_Q01201 P16284\n", + "Q03181 P01137\n", + "P23443 P01137\n", + "P01137 P23443\n", + "P01375 P23443\n", + "P23443 Q9H3D4\n", + "P31749 P23443\n", + "P48061 Q92569\n", + "Q92569 P31749\n", + "P01375 P42574\n", + "P42574 O14920\n", + "P42574 Q9H3D4\n", + "P42574 P31749\n", + "P48061 O00329\n", + "O00329 P31749\n", + "P01137 P48061\n", + "COMPLEX:Q04206_Q04864 P48061\n", + "COMPLEX:Q00653_Q01201 P48061\n", + "P01375 P01137\n", + "P01137 P31749\n", + "P31749 P01137\n", + "COMPLEX:Q04206_Q04864 P01137\n", + "COMPLEX:Q00653_Q01201 P01137\n", + "O14896 P01137\n", + "P01375 O14920\n", + "P01375 Q9Y6K9\n", + "P01375 O15111\n", + "Q9H3D4 P01375\n", + "P01375 P31749\n", + "COMPLEX:Q04206_Q04864 P01375\n", + "COMPLEX:Q00653_Q01201 P01375\n", + "P01375 P49137\n", + "P53350 P01375\n", + "P01375 O14896\n", + "O14896 P01375\n", + "Q9Y6K9 O14920\n", + "O15111 O14920\n", + "O14920 Q9H3D4\n", + "P31749 O14920\n", + "Q99759 O14920\n", + "P53350 O14920\n", + "Q9Y2U5 O14920\n", + "Q14164 COMPLEX:Q04206_Q04864\n", + "COMPLEX:Q04206_Q04864 Q14164\n", + "COMPLEX:Q00653_Q01201 Q14164\n", + "Q9Y6K9 O15111\n", + "P31749 Q9Y6K9\n", + "Q99759 Q9Y6K9\n", + "P41279 Q9Y6K9\n", + "Q9Y2U5 Q9Y6K9\n", + "Q9H3D4 O15111\n", + "P31749 O15111\n", + "O15111 COMPLEX:Q00653_Q01201\n", + "Q99759 O15111\n", + "P41279 O15111\n", + "Q9Y2U5 O15111\n", + "Q9H3D4 P31749\n", + "COMPLEX:Q04206_Q04864 Q9H3D4\n", + "COMPLEX:Q00653_Q01201 Q9H3D4\n", + "P53350 Q9H3D4\n", + "COMPLEX:Q04206_Q04864 P31749\n", + "COMPLEX:Q00653_Q01201 P31749\n", + "P31749 P41279\n", + "COMPLEX:Q04206_Q04864 P53350\n", + "COMPLEX:Q04206_Q04864 P41279\n", + "COMPLEX:Q00653_Q01201 P53350\n", + "COMPLEX:Q00653_Q01201 P41279\n", + "P49137 P53350\n", + "P41279 P53350\n", + "looking for paths in the network with length: 0 for node VIM and PTK2B\n", + "looking for paths in the network with length: 1 for node VIM and PTK2B\n", + "looking for paths in the network with length: 2 for node VIM and PTK2B\n", + "Found a path!\n", + "[['VIM', 'STAT3', 'PTK2B']]\n", + "looking for paths in the network with length: 0 for node VIM and COL1A1\n", + "looking for paths in the network with length: 1 for node VIM and COL1A1\n", + "looking for paths in the network with length: 2 for node VIM and COL1A1\n", + "Found a path!\n", + "[['VIM', 'CASP3', 'COL1A1'], ['VIM', 'CASP7', 'COL1A1']]\n", + "looking for paths in the network with length: 0 for node MAP4K4 and PTK2B\n", + "looking for paths in the network with length: 1 for node MAP4K4 and PTK2B\n", + "looking for paths in the network with length: 2 for node MAP4K4 and PTK2B\n", + "looking for paths in the network with length: 3 for node MAP4K4 and PTK2B\n", + "Found a path!\n", + "[['MAP4K4', 'CHUK', 'MYC', 'PTK2B'], ['MAP4K4', 'TNF', 'PIK3CG', 'PTK2B'], ['MAP4K4', 'TNF', 'TXN', 'PTK2B']]\n", + "looking for paths in the network with length: 0 for node MAP4K4 and COL1A1\n", + "looking for paths in the network with length: 1 for node MAP4K4 and COL1A1\n", + "looking for paths in the network with length: 2 for node MAP4K4 and COL1A1\n", + "looking for paths in the network with length: 3 for node MAP4K4 and COL1A1\n", + "Found a path!\n", + "[['MAP4K4', 'IKBKB', 'NFKB1', 'COL1A1'], ['MAP4K4', 'IKBKG', 'NFKB1', 'COL1A1'], ['MAP4K4', 'MAP3K3', 'NFKB1', 'COL1A1'], ['MAP4K4', 'MAP3K2', 'NFKB1', 'COL1A1'], ['MAP4K4', 'CHUK', 'NFKB1', 'COL1A1'], ['MAP4K4', 'TNF', 'TGFB1', 'COL1A1'], ['MAP4K4', 'TNF', 'NFKB1', 'COL1A1'], ['MAP4K4', 'TNF', 'RHOA', 'COL1A1'], ['MAP4K4', 'IKBKE', 'NFKB1', 'COL1A1'], ['MAP4K4', 'EPHB1', 'SRC', 'COL1A1'], ['MAP4K4', 'PPARG', 'SRC', 'COL1A1']]\n", + "looking for paths in the network with length: 0 for node PTK2B and COL1A1\n", + "looking for paths in the network with length: 1 for node PTK2B and COL1A1\n", + "looking for paths in the network with length: 2 for node PTK2B and COL1A1\n", + "Found a path!\n", + "[['PTK2B', 'RAC1', 'COL1A1'], ['PTK2B', 'SRC', 'COL1A1'], ['PTK2B', 'PIK3CA', 'COL1A1'], ['PTK2B', 'ITGA4', 'COL1A1']]\n", + "CPU times: user 15min 18s, sys: 436 ms, total: 15min 18s\n", + "Wall time: 15min 18s\n" + ] + }, + { + "name": "stdout", + "output_type": "stream", + "text": [ + "P54762 Q05397\n", + "COMPLEX:P05412_P53539 P12830\n", + "COMPLEX:P19838_Q04206 P12830\n", + "COMPLEX:P17535_P53539 P12830\n", + "COMPLEX:Q01201 P12830\n", + "COMPLEX:P15408_P17275 P12830\n", + "COMPLEX:P15407_P17535 P12830\n", + "COMPLEX:P01100_P17275 P12830\n", + "COMPLEX:P19838_Q04864 P12830\n", + "COMPLEX:Q04206 P12830\n", + "COMPLEX:P19838_Q01201 P12830\n", + "COMPLEX:P15407_P17275 P12830\n", + "COMPLEX:P05412_P17275 P12830\n", + "COMPLEX:P17535 P12830\n", + "COMPLEX:Q00653_Q01201 P12830\n", + "COMPLEX:P17275_P53539 P12830\n", + "COMPLEX:P19838_Q00653 P12830\n", + "COMPLEX:P15408_P17535 P12830\n", + "COMPLEX:Q00653_Q04206 P12830\n", + "COMPLEX:P19838 P12830\n", + "COMPLEX:Q04864 P12830\n", + "COMPLEX:P05412_P17535 P12830\n", + "COMPLEX:P01100_P05412 P12830\n", + "COMPLEX:P17275 P12830\n", + "COMPLEX:P05412_P15407 P12830\n", + "COMPLEX:P05412 P12830\n", + "COMPLEX:P01100_P17535 P12830\n", + "COMPLEX:Q04206_Q04864 P12830\n", + "COMPLEX:Q01201_Q04864 P12830\n", + "COMPLEX:Q00653 P12830\n", + "COMPLEX:Q00653_Q04864 P12830\n", + "COMPLEX:Q01201_Q04206 P12830\n", + "COMPLEX:P05412_P15408 P12830\n", + "COMPLEX:P17275_P17535 P12830\n", + "P37231 P12830\n", + "COMPLEX:P05412_P53539 P19022\n", + "COMPLEX:P19838_Q04206 P19022\n", + "COMPLEX:P17535_P53539 P19022\n", + "COMPLEX:Q01201 P19022\n", + "COMPLEX:P15408_P17275 P19022\n", + "COMPLEX:P15407_P17535 P19022\n", + "COMPLEX:P01100_P17275 P19022\n", + "COMPLEX:P19838_Q04864 P19022\n", + "COMPLEX:Q04206 P19022\n", + "COMPLEX:P19838_Q01201 P19022\n", + "COMPLEX:P15407_P17275 P19022\n", + "COMPLEX:P05412_P17275 P19022\n", + "COMPLEX:P17535 P19022\n", + "COMPLEX:Q00653_Q01201 P19022\n", + "COMPLEX:P17275_P53539 P19022\n", + "COMPLEX:P19838_Q00653 P19022\n", + "COMPLEX:P15408_P17535 P19022\n", + "COMPLEX:Q00653_Q04206 P19022\n", + "COMPLEX:P19838 P19022\n", + 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Q14289\n", + "COMPLEX:P01100_P17275 Q14289\n", + "COMPLEX:P15407_P17275 Q14289\n", + "COMPLEX:P05412_P17275 Q14289\n", + "COMPLEX:P17535 Q14289\n", + "COMPLEX:P17275_P53539 Q14289\n", + "COMPLEX:P15408_P17535 Q14289\n", + "COMPLEX:P05412_P17535 Q14289\n", + "COMPLEX:P01100_P05412 Q14289\n", + "COMPLEX:P17275 Q14289\n", + "COMPLEX:P05412_P15407 Q14289\n", + "COMPLEX:P05412 Q14289\n", + "COMPLEX:P01100_P17535 Q14289\n", + "COMPLEX:P05412_P15408 Q14289\n", + "COMPLEX:P17275_P17535 Q14289\n", + "P19838 P02452\n", + "P08047 P02452\n", + "Q02447 P02452\n", + "COMPLEX:P05412_P53539 P19838\n", + "COMPLEX:P05412_P53539 P08047\n", + "COMPLEX:P05412_P53539 Q02447\n", + "COMPLEX:P05412_P53539 P37231\n", + "COMPLEX:P19838_Q04206 P19838\n", + "COMPLEX:P19838_Q04206 P08047\n", + "COMPLEX:P19838_Q04206 Q02447\n", + "COMPLEX:P19838_Q04206 P42229\n", + "COMPLEX:P19838_Q04206 P41235\n", + "COMPLEX:P19838_Q04206 P37231\n", + "COMPLEX:P17535_P53539 P19838\n", + "COMPLEX:P17535_P53539 P08047\n", + "COMPLEX:P17535_P53539 Q02447\n", + "COMPLEX:P17535_P53539 P37231\n", + "COMPLEX:Q01201 P19838\n", + "COMPLEX:P15408_P17275 P19838\n", + "COMPLEX:P15407_P17535 P19838\n", + "P08047 P19838\n", + "COMPLEX:P01100_P17275 P19838\n", + "COMPLEX:P19838_Q04864 P19838\n", + "COMPLEX:Q04206 P19838\n", + "COMPLEX:P19838_Q01201 P19838\n", + "COMPLEX:P15407_P17275 P19838\n", + "COMPLEX:P05412_P17275 P19838\n", + "COMPLEX:P17535 P19838\n", + "P19838 P42229\n", + "COMPLEX:Q00653_Q01201 P19838\n", + "COMPLEX:P17275_P53539 P19838\n", + "COMPLEX:P19838_Q00653 P19838\n", + "COMPLEX:P15408_P17535 P19838\n", + "COMPLEX:Q00653_Q04206 P19838\n", + "COMPLEX:P19838 P19838\n", + "COMPLEX:Q04864 P19838\n", + "COMPLEX:P05412_P17535 P19838\n", + "COMPLEX:P01100_P05412 P19838\n", + "COMPLEX:P17275 P19838\n", + "COMPLEX:P05412_P15407 P19838\n", + "COMPLEX:P05412 P19838\n", + "COMPLEX:P01100_P17535 P19838\n", + "COMPLEX:Q04206_Q04864 P19838\n", + "COMPLEX:Q01201_Q04864 P19838\n", + "COMPLEX:Q00653 P19838\n", + "COMPLEX:Q00653_Q04864 P19838\n", + "COMPLEX:Q01201_Q04206 P19838\n", + "COMPLEX:P05412_P15408 P19838\n", + "COMPLEX:P17275_P17535 P19838\n", + "Q9Y2U5 P19838\n", + "P37231 P19838\n", + "P41235 Q9NQB0\n", + "COMPLEX:Q01201 P08047\n", + "COMPLEX:Q01201 Q02447\n", + "COMPLEX:Q01201 P42229\n", + "COMPLEX:Q01201 P41235\n", + "COMPLEX:Q01201 P37231\n", + "COMPLEX:P15408_P17275 P08047\n", + "COMPLEX:P15408_P17275 Q02447\n", + "COMPLEX:P15408_P17275 P37231\n", + "COMPLEX:P15407_P17535 P08047\n", + "COMPLEX:P15407_P17535 Q02447\n", + "COMPLEX:P15407_P17535 P37231\n", + "COMPLEX:P01100_P17275 P08047\n", + "COMPLEX:P19838_Q04864 P08047\n", + "COMPLEX:Q04206 P08047\n", + "COMPLEX:P19838_Q01201 P08047\n", + "COMPLEX:P15407_P17275 P08047\n", + "COMPLEX:P05412_P17275 P08047\n", + "COMPLEX:P17535 P08047\n", + "Q02447 P08047\n", + "COMPLEX:Q00653_Q01201 P08047\n", + "COMPLEX:P17275_P53539 P08047\n", + "COMPLEX:P19838_Q00653 P08047\n", + "COMPLEX:P15408_P17535 P08047\n", + "COMPLEX:Q00653_Q04206 P08047\n", + "COMPLEX:P19838 P08047\n", + "COMPLEX:Q04864 P08047\n", + "COMPLEX:P05412_P17535 P08047\n", + "P08047 P41235\n", + "COMPLEX:P01100_P05412 P08047\n", + "COMPLEX:P17275 P08047\n", + "COMPLEX:P05412_P15407 P08047\n", + "COMPLEX:P05412 P08047\n", + "COMPLEX:P01100_P17535 P08047\n", + "COMPLEX:Q04206_Q04864 P08047\n", + "COMPLEX:Q01201_Q04864 P08047\n", + "COMPLEX:Q00653 P08047\n", + "COMPLEX:Q00653_Q04864 P08047\n", + "COMPLEX:Q01201_Q04206 P08047\n", + "COMPLEX:P05412_P15408 P08047\n", + "COMPLEX:P17275_P17535 P08047\n", + "P08047 P54762\n", + "P37231 P08047\n", + "COMPLEX:P01100_P17275 Q02447\n", + "COMPLEX:P01100_P17275 P37231\n", + "COMPLEX:P19838_Q04864 Q02447\n", + "COMPLEX:P19838_Q04864 P42229\n", + "COMPLEX:P19838_Q04864 P41235\n", + "COMPLEX:P19838_Q04864 P37231\n", + "COMPLEX:Q04206 Q02447\n", + "COMPLEX:Q04206 P42229\n", + "COMPLEX:Q04206 P41235\n", + "COMPLEX:Q04206 P37231\n", + "COMPLEX:P19838_Q01201 Q02447\n", + "COMPLEX:P19838_Q01201 P42229\n", + "COMPLEX:P19838_Q01201 P41235\n", + "COMPLEX:P19838_Q01201 P37231\n", + "COMPLEX:P15407_P17275 Q02447\n", + "COMPLEX:P15407_P17275 P37231\n", + "COMPLEX:P05412_P17275 Q02447\n", + "COMPLEX:P05412_P17275 P37231\n", + "COMPLEX:P17535 Q02447\n", + "COMPLEX:P17535 P37231\n", + "COMPLEX:Q00653_Q01201 Q02447\n", + "COMPLEX:P17275_P53539 Q02447\n", + "COMPLEX:P19838_Q00653 Q02447\n", + "COMPLEX:P15408_P17535 Q02447\n", + "COMPLEX:Q00653_Q04206 Q02447\n", + "COMPLEX:P19838 Q02447\n", + "COMPLEX:Q04864 Q02447\n", + "COMPLEX:P05412_P17535 Q02447\n", + "COMPLEX:P01100_P05412 Q02447\n", + "COMPLEX:P17275 Q02447\n", + "COMPLEX:P05412_P15407 Q02447\n", + "COMPLEX:P05412 Q02447\n", + "COMPLEX:P01100_P17535 Q02447\n", + "COMPLEX:Q04206_Q04864 Q02447\n", + "COMPLEX:Q01201_Q04864 Q02447\n", + "COMPLEX:Q00653 Q02447\n", + "COMPLEX:Q00653_Q04864 Q02447\n", + "COMPLEX:Q01201_Q04206 Q02447\n", + "COMPLEX:P05412_P15408 Q02447\n", + "COMPLEX:P17275_P17535 Q02447\n", + "COMPLEX:Q00653_Q01201 P42229\n", + "COMPLEX:P19838_Q00653 P42229\n", + "COMPLEX:Q00653_Q04206 P42229\n", + "COMPLEX:P19838 P42229\n", + "COMPLEX:Q04864 P42229\n", + "COMPLEX:Q04206_Q04864 P42229\n", + "COMPLEX:Q01201_Q04864 P42229\n", + "COMPLEX:Q00653 P42229\n", + "COMPLEX:Q00653_Q04864 P42229\n", + "COMPLEX:Q01201_Q04206 P42229\n", + "P37231 P42229\n", + "COMPLEX:Q00653_Q01201 P41235\n", + "COMPLEX:Q00653_Q01201 P37231\n", + "COMPLEX:P17275_P53539 P37231\n", + "COMPLEX:P19838_Q00653 P41235\n", + "COMPLEX:P19838_Q00653 P37231\n", + "COMPLEX:P15408_P17535 P37231\n", + "COMPLEX:Q00653_Q04206 P41235\n", + "COMPLEX:Q00653_Q04206 P37231\n", + "COMPLEX:P19838 P41235\n", + "COMPLEX:P19838 P37231\n", + "COMPLEX:Q04864 P41235\n", + "COMPLEX:Q04864 P37231\n", + "COMPLEX:P05412_P17535 P37231\n", + "COMPLEX:Q04206_Q04864 P41235\n", + "COMPLEX:Q01201_Q04864 P41235\n", + "COMPLEX:Q00653 P41235\n", + "COMPLEX:Q00653_Q04864 P41235\n", + "COMPLEX:Q01201_Q04206 P41235\n", + "COMPLEX:P01100_P05412 P37231\n", + "COMPLEX:P17275 P37231\n", + "COMPLEX:P05412_P15407 P37231\n", + "COMPLEX:P05412 P37231\n", + "COMPLEX:P01100_P17535 P37231\n", + "COMPLEX:Q04206_Q04864 P37231\n", + "COMPLEX:Q01201_Q04864 P37231\n", + "COMPLEX:Q00653 P37231\n", + "COMPLEX:Q00653_Q04864 P37231\n", + "COMPLEX:Q01201_Q04206 P37231\n", + "COMPLEX:P05412_P15408 P37231\n", + "COMPLEX:P17275_P17535 P37231\n", + "looking for paths in the network with length: 0 for node SRC and PTK2B\n", + "looking for paths in the network with length: 1 for node SRC and PTK2B\n", + "Found a path!\n", + "[['SRC', 'PTK2B']]\n", + "looking for paths in the network with length: 0 for node SRC and COL1A1\n", + "looking for paths in the network with length: 1 for node SRC and COL1A1\n", + "Found a path!\n", + "[['SRC', 'COL1A1']]\n", + "looking for paths in the network with length: 0 for node NOTCH1 and PTK2\n", + "looking for paths in the network with length: 1 for node NOTCH1 and PTK2\n", + "looking for paths in the network with length: 2 for node NOTCH1 and PTK2\n", + "Found a path!\n", + "[['NOTCH1', 'RELB', 'PTK2'], ['NOTCH1', 'COMPLEX:P19838_Q04864', 'PTK2'], ['NOTCH1', 'COMPLEX:Q00653_Q01201', 'PTK2'], ['NOTCH1', 'RELA', 'PTK2'], ['NOTCH1', 'NFKB1', 'PTK2'], ['NOTCH1', 'COMPLEX:Q00653_Q04206', 'PTK2'], ['NOTCH1', 'COMPLEX:P19838_Q04206', 'PTK2'], ['NOTCH1', 'COMPLEX:P19838_Q01201', 'PTK2'], ['NOTCH1', 'COMPLEX:Q04206_Q04864', 'PTK2'], ['NOTCH1', 'COMPLEX:P19838_Q00653', 'PTK2'], ['NOTCH1', 'REL', 'PTK2'], ['NOTCH1', 'COMPLEX:Q01201_Q04206', 'PTK2'], ['NOTCH1', 'COMPLEX:Q01201_Q04864', 'PTK2'], ['NOTCH1', 'NFKB2', 'PTK2'], ['NOTCH1', 'COMPLEX:Q00653_Q04864', 'PTK2']]\n", + "looking for paths in the network with length: 0 for node NOTCH1 and CDH1\n", + "looking for paths in the network with length: 1 for node NOTCH1 and CDH1\n", + "looking for paths in the network with length: 2 for node NOTCH1 and CDH1\n", + "Found a path!\n", + "[['NOTCH1', 'RELB', 'CDH1'], ['NOTCH1', 'COMPLEX:P19838_Q04864', 'CDH1'], ['NOTCH1', 'COMPLEX:Q00653_Q01201', 'CDH1'], ['NOTCH1', 'RELA', 'CDH1'], ['NOTCH1', 'PPARG', 'CDH1'], ['NOTCH1', 'NFKB1', 'CDH1'], ['NOTCH1', 'COMPLEX:Q00653_Q04206', 'CDH1'], ['NOTCH1', 'COMPLEX:P19838_Q04206', 'CDH1'], ['NOTCH1', 'COMPLEX:P19838_Q01201', 'CDH1'], ['NOTCH1', 'COMPLEX:Q04206_Q04864', 'CDH1'], ['NOTCH1', 'COMPLEX:P19838_Q00653', 'CDH1'], ['NOTCH1', 'REL', 'CDH1'], ['NOTCH1', 'COMPLEX:Q01201_Q04206', 'CDH1'], ['NOTCH1', 'COMPLEX:Q01201_Q04864', 'CDH1'], ['NOTCH1', 'NFKB2', 'CDH1'], ['NOTCH1', 'COMPLEX:Q00653_Q04864', 'CDH1']]\n", + "looking for paths in the network with length: 0 for node NOTCH1 and CDH2\n", + "looking for paths in the network with length: 1 for node NOTCH1 and CDH2\n", + "Found a path!\n", + "[['NOTCH1', 'CDH2']]\n", + "looking for paths in the network with length: 0 for node NOTCH1 and VIM\n", + "looking for paths in the network with length: 1 for node NOTCH1 and VIM\n", + "looking for paths in the network with length: 2 for node NOTCH1 and VIM\n", + "Found a path!\n", + "[['NOTCH1', 'RELB', 'VIM'], ['NOTCH1', 'SP3', 'VIM'], ['NOTCH1', 'COMPLEX:P19838_Q04864', 'VIM'], ['NOTCH1', 'COMPLEX:Q00653_Q01201', 'VIM'], ['NOTCH1', 'RELA', 'VIM'], ['NOTCH1', 'NFKB1', 'VIM'], ['NOTCH1', 'SP1', 'VIM'], ['NOTCH1', 'COMPLEX:Q00653_Q04206', 'VIM'], ['NOTCH1', 'COMPLEX:P19838_Q04206', 'VIM'], ['NOTCH1', 'COMPLEX:P19838_Q01201', 'VIM'], ['NOTCH1', 'COMPLEX:Q04206_Q04864', 'VIM'], ['NOTCH1', 'COMPLEX:P19838_Q00653', 'VIM'], ['NOTCH1', 'REL', 'VIM'], ['NOTCH1', 'NFKB1', 'VIM'], ['NOTCH1', 'COMPLEX:Q01201_Q04206', 'VIM'], ['NOTCH1', 'COMPLEX:Q01201_Q04864', 'VIM'], ['NOTCH1', 'NFKB2', 'VIM'], ['NOTCH1', 'COMPLEX:Q00653_Q04864', 'VIM']]\n", + "looking for paths in the network with length: 0 for node NOTCH1 and MAP4K4\n", + "looking for paths in the network with length: 1 for node NOTCH1 and MAP4K4\n", + "looking for paths in the network with length: 2 for node NOTCH1 and MAP4K4\n", + "Found a path!\n", + "[['NOTCH1', 'PPARG', 'MAP4K4']]\n", + "looking for paths in the network with length: 0 for node NOTCH1 and PTK2B\n", + "looking for paths in the network with length: 1 for node NOTCH1 and PTK2B\n", + "looking for paths in the network with length: 2 for node NOTCH1 and PTK2B\n", + "looking for paths in the network with length: 3 for node NOTCH1 and PTK2B\n" + ] + }, + { + "name": "stdout", + "output_type": "stream", + "text": [ + "Found a path!\n", + "[['NOTCH1', 'RELB', 'SRC', 'PTK2B'], ['NOTCH1', 'RELB', 'PTK2', 'PTK2B'], ['NOTCH1', 'SP3', 'COMPLEX:P15407_P17275', 'PTK2B'], ['NOTCH1', 'SP3', 'COMPLEX:P05412_P53539', 'PTK2B'], ['NOTCH1', 'SP3', 'COMPLEX:P05412_P17535', 'PTK2B'], ['NOTCH1', 'SP3', 'COMPLEX:P17275_P53539', 'PTK2B'], ['NOTCH1', 'SP3', 'COMPLEX:P05412_P15407', 'PTK2B'], ['NOTCH1', 'SP3', 'COMPLEX:P05412_P17275', 'PTK2B'], ['NOTCH1', 'SP3', 'COMPLEX:P01100_P17275', 'PTK2B'], ['NOTCH1', 'SP3', 'JUND', 'PTK2B'], ['NOTCH1', 'SP3', 'COMPLEX:P05412_P15408', 'PTK2B'], ['NOTCH1', 'SP3', 'COMPLEX:P01100_P05412', 'PTK2B'], ['NOTCH1', 'SP3', 'COMPLEX:P17535_P53539', 'PTK2B'], ['NOTCH1', 'SP3', 'SRC', 'PTK2B'], ['NOTCH1', 'SP3', 'COMPLEX:P15408_P17535', 'PTK2B'], ['NOTCH1', 'SP3', 'JUN', 'PTK2B'], ['NOTCH1', 'SP3', 'JUNB', 'PTK2B'], ['NOTCH1', 'SP3', 'COMPLEX:P15408_P17275', 'PTK2B'], ['NOTCH1', 'SP3', 'COMPLEX:P01100_P17535', 'PTK2B'], ['NOTCH1', 'SP3', 'COMPLEX:P15407_P17535', 'PTK2B'], ['NOTCH1', 'SP3', 'COMPLEX:P17275_P17535', 'PTK2B'], ['NOTCH1', 'COL1A1', 'SRC', 'PTK2B'], ['NOTCH1', 'COMPLEX:P19838_Q04864', 'SRC', 'PTK2B'], ['NOTCH1', 'COMPLEX:P19838_Q04864', 'PTK2', 'PTK2B'], ['NOTCH1', 'COMPLEX:Q00653_Q01201', 'SRC', 'PTK2B'], ['NOTCH1', 'COMPLEX:Q00653_Q01201', 'PTK2', 'PTK2B'], ['NOTCH1', 'CDH2', 'COMPLEX:P15407_P17275', 'PTK2B'], ['NOTCH1', 'CDH2', 'COMPLEX:P05412_P53539', 'PTK2B'], ['NOTCH1', 'CDH2', 'COMPLEX:P05412_P17535', 'PTK2B'], ['NOTCH1', 'CDH2', 'COMPLEX:P17275_P53539', 'PTK2B'], ['NOTCH1', 'CDH2', 'COMPLEX:P05412_P15407', 'PTK2B'], ['NOTCH1', 'CDH2', 'COMPLEX:P05412_P17275', 'PTK2B'], ['NOTCH1', 'CDH2', 'COMPLEX:P01100_P17275', 'PTK2B'], ['NOTCH1', 'CDH2', 'JUND', 'PTK2B'], ['NOTCH1', 'CDH2', 'COMPLEX:P05412_P15408', 'PTK2B'], ['NOTCH1', 'CDH2', 'COMPLEX:P01100_P05412', 'PTK2B'], ['NOTCH1', 'CDH2', 'COMPLEX:P17535_P53539', 'PTK2B'], ['NOTCH1', 'CDH2', 'SRC', 'PTK2B'], ['NOTCH1', 'CDH2', 'COMPLEX:P15408_P17535', 'PTK2B'], ['NOTCH1', 'CDH2', 'JUN', 'PTK2B'], ['NOTCH1', 'CDH2', 'JUNB', 'PTK2B'], ['NOTCH1', 'CDH2', 'COMPLEX:P15408_P17275', 'PTK2B'], ['NOTCH1', 'CDH2', 'COMPLEX:P01100_P17535', 'PTK2B'], ['NOTCH1', 'CDH2', 'COMPLEX:P15407_P17535', 'PTK2B'], ['NOTCH1', 'CDH2', 'COMPLEX:P17275_P17535', 'PTK2B'], ['NOTCH1', 'RELA', 'SRC', 'PTK2B'], ['NOTCH1', 'RELA', 'PTK2', 'PTK2B'], ['NOTCH1', 'PPARG', 'COMPLEX:P15407_P17275', 'PTK2B'], ['NOTCH1', 'PPARG', 'COMPLEX:P05412_P53539', 'PTK2B'], ['NOTCH1', 'PPARG', 'COMPLEX:P05412_P17535', 'PTK2B'], ['NOTCH1', 'PPARG', 'COMPLEX:P17275_P53539', 'PTK2B'], ['NOTCH1', 'PPARG', 'COMPLEX:P05412_P15407', 'PTK2B'], ['NOTCH1', 'PPARG', 'COMPLEX:P05412_P17275', 'PTK2B'], ['NOTCH1', 'PPARG', 'COMPLEX:P01100_P17275', 'PTK2B'], ['NOTCH1', 'PPARG', 'JUND', 'PTK2B'], ['NOTCH1', 'PPARG', 'COMPLEX:P05412_P15408', 'PTK2B'], ['NOTCH1', 'PPARG', 'COMPLEX:P01100_P05412', 'PTK2B'], ['NOTCH1', 'PPARG', 'COMPLEX:P17535_P53539', 'PTK2B'], ['NOTCH1', 'PPARG', 'SRC', 'PTK2B'], ['NOTCH1', 'PPARG', 'COMPLEX:P15408_P17535', 'PTK2B'], ['NOTCH1', 'PPARG', 'JUN', 'PTK2B'], ['NOTCH1', 'PPARG', 'JUNB', 'PTK2B'], ['NOTCH1', 'PPARG', 'COMPLEX:P15408_P17275', 'PTK2B'], ['NOTCH1', 'PPARG', 'COMPLEX:P01100_P17535', 'PTK2B'], ['NOTCH1', 'PPARG', 'COMPLEX:P15407_P17535', 'PTK2B'], ['NOTCH1', 'PPARG', 'COMPLEX:P17275_P17535', 'PTK2B'], ['NOTCH1', 'NFKB1', 'SRC', 'PTK2B'], ['NOTCH1', 'NFKB1', 'PTK2', 'PTK2B'], ['NOTCH1', 'SP1', 'COMPLEX:P15407_P17275', 'PTK2B'], ['NOTCH1', 'SP1', 'COMPLEX:P05412_P53539', 'PTK2B'], ['NOTCH1', 'SP1', 'COMPLEX:P05412_P17535', 'PTK2B'], ['NOTCH1', 'SP1', 'COMPLEX:P17275_P53539', 'PTK2B'], ['NOTCH1', 'SP1', 'COMPLEX:P05412_P15407', 'PTK2B'], ['NOTCH1', 'SP1', 'COMPLEX:P05412_P17275', 'PTK2B'], ['NOTCH1', 'SP1', 'COMPLEX:P01100_P17275', 'PTK2B'], ['NOTCH1', 'SP1', 'JUND', 'PTK2B'], ['NOTCH1', 'SP1', 'COMPLEX:P05412_P15408', 'PTK2B'], ['NOTCH1', 'SP1', 'COMPLEX:P01100_P05412', 'PTK2B'], ['NOTCH1', 'SP1', 'COMPLEX:P17535_P53539', 'PTK2B'], ['NOTCH1', 'SP1', 'SRC', 'PTK2B'], ['NOTCH1', 'SP1', 'COMPLEX:P15408_P17535', 'PTK2B'], ['NOTCH1', 'SP1', 'JUN', 'PTK2B'], ['NOTCH1', 'SP1', 'JUNB', 'PTK2B'], ['NOTCH1', 'SP1', 'COMPLEX:P15408_P17275', 'PTK2B'], ['NOTCH1', 'SP1', 'COMPLEX:P01100_P17535', 'PTK2B'], ['NOTCH1', 'SP1', 'COMPLEX:P15407_P17535', 'PTK2B'], ['NOTCH1', 'SP1', 'COMPLEX:P17275_P17535', 'PTK2B'], ['NOTCH1', 'COMPLEX:Q00653_Q04206', 'SRC', 'PTK2B'], ['NOTCH1', 'COMPLEX:Q00653_Q04206', 'PTK2', 'PTK2B'], ['NOTCH1', 'COMPLEX:P19838_Q04206', 'SRC', 'PTK2B'], ['NOTCH1', 'COMPLEX:P19838_Q04206', 'PTK2', 'PTK2B'], ['NOTCH1', 'COMPLEX:P19838_Q01201', 'SRC', 'PTK2B'], ['NOTCH1', 'COMPLEX:P19838_Q01201', 'PTK2', 'PTK2B'], ['NOTCH1', 'COMPLEX:Q04206_Q04864', 'SRC', 'PTK2B'], ['NOTCH1', 'COMPLEX:Q04206_Q04864', 'PTK2', 'PTK2B'], ['NOTCH1', 'COMPLEX:P19838_Q00653', 'SRC', 'PTK2B'], ['NOTCH1', 'COMPLEX:P19838_Q00653', 'PTK2', 'PTK2B'], ['NOTCH1', 'REL', 'SRC', 'PTK2B'], ['NOTCH1', 'REL', 'PTK2', 'PTK2B'], ['NOTCH1', 'NFKB1', 'COMPLEX:P15407_P17275', 'PTK2B'], ['NOTCH1', 'NFKB1', 'COMPLEX:P05412_P53539', 'PTK2B'], ['NOTCH1', 'NFKB1', 'COMPLEX:P05412_P17535', 'PTK2B'], ['NOTCH1', 'NFKB1', 'COMPLEX:P17275_P53539', 'PTK2B'], ['NOTCH1', 'NFKB1', 'COMPLEX:P05412_P15407', 'PTK2B'], ['NOTCH1', 'NFKB1', 'COMPLEX:P05412_P17275', 'PTK2B'], ['NOTCH1', 'NFKB1', 'COMPLEX:P01100_P17275', 'PTK2B'], ['NOTCH1', 'NFKB1', 'JUND', 'PTK2B'], ['NOTCH1', 'NFKB1', 'COMPLEX:P05412_P15408', 'PTK2B'], ['NOTCH1', 'NFKB1', 'COMPLEX:P01100_P05412', 'PTK2B'], ['NOTCH1', 'NFKB1', 'COMPLEX:P17535_P53539', 'PTK2B'], ['NOTCH1', 'NFKB1', 'SRC', 'PTK2B'], ['NOTCH1', 'NFKB1', 'COMPLEX:P15408_P17535', 'PTK2B'], ['NOTCH1', 'NFKB1', 'JUN', 'PTK2B'], ['NOTCH1', 'NFKB1', 'JUNB', 'PTK2B'], ['NOTCH1', 'NFKB1', 'COMPLEX:P15408_P17275', 'PTK2B'], ['NOTCH1', 'NFKB1', 'COMPLEX:P01100_P17535', 'PTK2B'], ['NOTCH1', 'NFKB1', 'COMPLEX:P15407_P17535', 'PTK2B'], ['NOTCH1', 'NFKB1', 'COMPLEX:P17275_P17535', 'PTK2B'], ['NOTCH1', 'COMPLEX:Q01201_Q04206', 'SRC', 'PTK2B'], ['NOTCH1', 'COMPLEX:Q01201_Q04206', 'PTK2', 'PTK2B'], ['NOTCH1', 'COMPLEX:Q01201_Q04864', 'SRC', 'PTK2B'], ['NOTCH1', 'COMPLEX:Q01201_Q04864', 'PTK2', 'PTK2B'], ['NOTCH1', 'NFKB2', 'SRC', 'PTK2B'], ['NOTCH1', 'NFKB2', 'PTK2', 'PTK2B'], ['NOTCH1', 'COMPLEX:Q00653_Q04864', 'SRC', 'PTK2B'], ['NOTCH1', 'COMPLEX:Q00653_Q04864', 'PTK2', 'PTK2B']]\n", + "looking for paths in the network with length: 0 for node NOTCH1 and COL1A1\n", + "looking for paths in the network with length: 1 for node NOTCH1 and COL1A1\n", + "Found a path!\n", + "[['NOTCH1', 'COL1A1']]\n", + "looking for paths in the network with length: 0 for node PTK2 and CDH1\n", + "looking for paths in the network with length: 1 for node PTK2 and CDH1\n", + "looking for paths in the network with length: 2 for node PTK2 and CDH1\n", + "Found a path!\n", + "[['PTK2', 'RELB', 'CDH1'], ['PTK2', 'COMPLEX:P19838_Q04864', 'CDH1'], ['PTK2', 'COMPLEX:Q00653_Q01201', 'CDH1'], ['PTK2', 'SRC', 'CDH1'], ['PTK2', 'RELA', 'CDH1'], ['PTK2', 'NFKB1', 'CDH1'], ['PTK2', 'COMPLEX:Q00653_Q04206', 'CDH1'], ['PTK2', 'COMPLEX:P19838_Q04206', 'CDH1'], ['PTK2', 'COMPLEX:P19838_Q01201', 'CDH1'], ['PTK2', 'COMPLEX:Q04206_Q04864', 'CDH1'], ['PTK2', 'COMPLEX:P19838_Q00653', 'CDH1'], ['PTK2', 'REL', 'CDH1'], ['PTK2', 'COMPLEX:Q01201_Q04206', 'CDH1'], ['PTK2', 'COMPLEX:Q01201_Q04864', 'CDH1'], ['PTK2', 'NFKB2', 'CDH1'], ['PTK2', 'COMPLEX:Q00653_Q04864', 'CDH1']]\n", + "looking for paths in the network with length: 0 for node PTK2 and CDH2\n", + "looking for paths in the network with length: 1 for node PTK2 and CDH2\n", + "looking for paths in the network with length: 2 for node PTK2 and CDH2\n", + "Found a path!\n", + "[['PTK2', 'RELB', 'CDH2'], ['PTK2', 'COMPLEX:P19838_Q04864', 'CDH2'], ['PTK2', 'COMPLEX:Q00653_Q01201', 'CDH2'], ['PTK2', 'SRC', 'CDH2'], ['PTK2', 'RELA', 'CDH2'], ['PTK2', 'NFKB1', 'CDH2'], ['PTK2', 'COMPLEX:Q00653_Q04206', 'CDH2'], ['PTK2', 'COMPLEX:P19838_Q04206', 'CDH2'], ['PTK2', 'COMPLEX:P19838_Q01201', 'CDH2'], ['PTK2', 'COMPLEX:Q04206_Q04864', 'CDH2'], ['PTK2', 'COMPLEX:P19838_Q00653', 'CDH2'], ['PTK2', 'REL', 'CDH2'], ['PTK2', 'COMPLEX:Q01201_Q04206', 'CDH2'], ['PTK2', 'COMPLEX:Q01201_Q04864', 'CDH2'], ['PTK2', 'NFKB2', 'CDH2'], ['PTK2', 'COMPLEX:Q00653_Q04864', 'CDH2']]\n", + "looking for paths in the network with length: 0 for node PTK2 and VIM\n", + "looking for paths in the network with length: 1 for node PTK2 and VIM\n", + "looking for paths in the network with length: 2 for node PTK2 and VIM\n", + "Found a path!\n", + "[['PTK2', 'RELB', 'VIM'], ['PTK2', 'COMPLEX:P19838_Q04864', 'VIM'], ['PTK2', 'COMPLEX:Q00653_Q01201', 'VIM'], ['PTK2', 'RELA', 'VIM'], ['PTK2', 'NFKB1', 'VIM'], ['PTK2', 'COMPLEX:Q00653_Q04206', 'VIM'], ['PTK2', 'COMPLEX:P19838_Q04206', 'VIM'], ['PTK2', 'COMPLEX:P19838_Q01201', 'VIM'], ['PTK2', 'COMPLEX:Q04206_Q04864', 'VIM'], ['PTK2', 'COMPLEX:P19838_Q00653', 'VIM'], ['PTK2', 'REL', 'VIM'], ['PTK2', 'COMPLEX:Q01201_Q04206', 'VIM'], ['PTK2', 'COMPLEX:Q01201_Q04864', 'VIM'], ['PTK2', 'NFKB2', 'VIM'], ['PTK2', 'COMPLEX:Q00653_Q04864', 'VIM']]\n", + "looking for paths in the network with length: 0 for node PTK2 and MAP4K4\n", + "looking for paths in the network with length: 1 for node PTK2 and MAP4K4\n", + "looking for paths in the network with length: 2 for node PTK2 and MAP4K4\n", + "Found a path!\n", + "[['PTK2', 'EPHB1', 'MAP4K4']]\n", + "looking for paths in the network with length: 0 for node PTK2 and PTK2B\n", + "looking for paths in the network with length: 1 for node PTK2 and PTK2B\n", + "Found a path!\n", + "[['PTK2', 'PTK2B']]\n", + "looking for paths in the network with length: 0 for node PTK2 and COL1A1\n", + "looking for paths in the network with length: 1 for node PTK2 and COL1A1\n", + "looking for paths in the network with length: 2 for node PTK2 and COL1A1\n", + "Found a path!\n", + "[['PTK2', 'SRC', 'COL1A1']]\n", + "looking for paths in the network with length: 0 for node CDH1 and CDH2\n", + "looking for paths in the network with length: 1 for node CDH1 and CDH2\n", + "looking for paths in the network with length: 2 for node CDH1 and CDH2\n", + "Found a path!\n", + "[['CDH1', 'COMPLEX:P15407_P17275', 'CDH2'], ['CDH1', 'COMPLEX:P05412_P53539', 'CDH2'], ['CDH1', 'COMPLEX:P05412_P17535', 'CDH2'], ['CDH1', 'COMPLEX:P17275_P53539', 'CDH2'], ['CDH1', 'COMPLEX:P05412_P15407', 'CDH2'], ['CDH1', 'COMPLEX:P05412_P17275', 'CDH2'], ['CDH1', 'COMPLEX:P01100_P17275', 'CDH2'], ['CDH1', 'NFKB1', 'CDH2'], ['CDH1', 'COMPLEX:P19838_Q04206', 'CDH2'], ['CDH1', 'JUND', 'CDH2'], ['CDH1', 'COMPLEX:P19838_Q00653', 'CDH2'], ['CDH1', 'REL', 'CDH2'], ['CDH1', 'COMPLEX:Q01201_Q04206', 'CDH2'], ['CDH1', 'COMPLEX:Q01201_Q04864', 'CDH2'], ['CDH1', 'NFKB2', 'CDH2'], ['CDH1', 'RELB', 'CDH2'], ['CDH1', 'COMPLEX:P05412_P15408', 'CDH2'], ['CDH1', 'COMPLEX:P19838_Q04864', 'CDH2'], ['CDH1', 'COMPLEX:Q00653_Q01201', 'CDH2'], ['CDH1', 'COMPLEX:P01100_P05412', 'CDH2'], ['CDH1', 'COMPLEX:P17535_P53539', 'CDH2'], ['CDH1', 'SRC', 'CDH2'], ['CDH1', 'COMPLEX:P15408_P17535', 'CDH2'], ['CDH1', 'JUN', 'CDH2'], ['CDH1', 'JUNB', 'CDH2'], ['CDH1', 'RELA', 'CDH2'], ['CDH1', 'PPARG', 'CDH2'], ['CDH1', 'COMPLEX:Q00653_Q04206', 'CDH2'], ['CDH1', 'COMPLEX:P19838_Q01201', 'CDH2'], ['CDH1', 'COMPLEX:P15408_P17275', 'CDH2'], ['CDH1', 'COMPLEX:P01100_P17535', 'CDH2'], ['CDH1', 'COMPLEX:Q04206_Q04864', 'CDH2'], ['CDH1', 'COMPLEX:P15407_P17535', 'CDH2'], ['CDH1', 'COMPLEX:P17275_P17535', 'CDH2'], ['CDH1', 'COMPLEX:Q00653_Q04864', 'CDH2']]\n", + "looking for paths in the network with length: 0 for node CDH1 and VIM\n", + "looking for paths in the network with length: 1 for node CDH1 and VIM\n", + "looking for paths in the network with length: 2 for node CDH1 and VIM\n", + "Found a path!\n", + "[['CDH1', 'COMPLEX:P15407_P17275', 'VIM'], ['CDH1', 'COMPLEX:P05412_P53539', 'VIM'], ['CDH1', 'COMPLEX:P05412_P17535', 'VIM'], ['CDH1', 'COMPLEX:P17275_P53539', 'VIM'], ['CDH1', 'COMPLEX:P05412_P15407', 'VIM'], ['CDH1', 'COMPLEX:P05412_P17275', 'VIM'], ['CDH1', 'COMPLEX:P01100_P17275', 'VIM'], ['CDH1', 'NFKB1', 'VIM'], ['CDH1', 'COMPLEX:P19838_Q04206', 'VIM'], ['CDH1', 'JUND', 'VIM'], ['CDH1', 'COMPLEX:P19838_Q00653', 'VIM'], ['CDH1', 'REL', 'VIM'], ['CDH1', 'COMPLEX:Q01201_Q04206', 'VIM'], ['CDH1', 'COMPLEX:Q01201_Q04864', 'VIM'], ['CDH1', 'NFKB2', 'VIM'], ['CDH1', 'RELB', 'VIM'], ['CDH1', 'COMPLEX:P05412_P15408', 'VIM'], ['CDH1', 'COMPLEX:P19838_Q04864', 'VIM'], ['CDH1', 'COMPLEX:Q00653_Q01201', 'VIM'], ['CDH1', 'COMPLEX:P01100_P05412', 'VIM'], ['CDH1', 'COMPLEX:P17535_P53539', 'VIM'], ['CDH1', 'COMPLEX:P15408_P17535', 'VIM'], ['CDH1', 'JUN', 'VIM'], ['CDH1', 'JUNB', 'VIM'], ['CDH1', 'RELA', 'VIM'], ['CDH1', 'COMPLEX:Q00653_Q04206', 'VIM'], ['CDH1', 'COMPLEX:P19838_Q01201', 'VIM'], ['CDH1', 'COMPLEX:P15408_P17275', 'VIM'], ['CDH1', 'COMPLEX:P01100_P17535', 'VIM'], ['CDH1', 'COMPLEX:Q04206_Q04864', 'VIM'], ['CDH1', 'COMPLEX:P15407_P17535', 'VIM'], ['CDH1', 'COMPLEX:P17275_P17535', 'VIM'], ['CDH1', 'COMPLEX:Q00653_Q04864', 'VIM']]\n", + "looking for paths in the network with length: 0 for node CDH1 and MAP4K4\n", + "looking for paths in the network with length: 1 for node CDH1 and MAP4K4\n", + "looking for paths in the network with length: 2 for node CDH1 and MAP4K4\n", + "Found a path!\n", + "[['CDH1', 'PPARG', 'MAP4K4']]\n", + "looking for paths in the network with length: 0 for node CDH1 and PTK2B\n", + "looking for paths in the network with length: 1 for node CDH1 and PTK2B\n", + "looking for paths in the network with length: 2 for node CDH1 and PTK2B\n", + "Found a path!\n", + "[['CDH1', 'COMPLEX:P15407_P17275', 'PTK2B'], ['CDH1', 'COMPLEX:P05412_P53539', 'PTK2B'], ['CDH1', 'COMPLEX:P05412_P17535', 'PTK2B'], ['CDH1', 'COMPLEX:P17275_P53539', 'PTK2B'], ['CDH1', 'COMPLEX:P05412_P15407', 'PTK2B'], ['CDH1', 'COMPLEX:P05412_P17275', 'PTK2B'], ['CDH1', 'COMPLEX:P01100_P17275', 'PTK2B'], ['CDH1', 'JUND', 'PTK2B'], ['CDH1', 'COMPLEX:P05412_P15408', 'PTK2B'], ['CDH1', 'COMPLEX:P01100_P05412', 'PTK2B'], ['CDH1', 'COMPLEX:P17535_P53539', 'PTK2B'], ['CDH1', 'SRC', 'PTK2B'], ['CDH1', 'COMPLEX:P15408_P17535', 'PTK2B'], ['CDH1', 'JUN', 'PTK2B'], ['CDH1', 'JUNB', 'PTK2B'], ['CDH1', 'COMPLEX:P15408_P17275', 'PTK2B'], ['CDH1', 'COMPLEX:P01100_P17535', 'PTK2B'], ['CDH1', 'COMPLEX:P15407_P17535', 'PTK2B'], ['CDH1', 'COMPLEX:P17275_P17535', 'PTK2B']]\n", + "looking for paths in the network with length: 0 for node CDH1 and COL1A1\n", + "looking for paths in the network with length: 1 for node CDH1 and COL1A1\n", + "looking for paths in the network with length: 2 for node CDH1 and COL1A1\n", + "Found a path!\n", + "[['CDH1', 'SRC', 'COL1A1']]\n", + "looking for paths in the network with length: 0 for node CDH2 and VIM\n", + "looking for paths in the network with length: 1 for node CDH2 and VIM\n", + "looking for paths in the network with length: 2 for node CDH2 and VIM\n", + "Found a path!\n", + "[['CDH2', 'COMPLEX:P15407_P17275', 'VIM'], ['CDH2', 'COMPLEX:P05412_P53539', 'VIM'], ['CDH2', 'COMPLEX:P05412_P17535', 'VIM'], ['CDH2', 'COMPLEX:P17275_P53539', 'VIM'], ['CDH2', 'COMPLEX:P05412_P15407', 'VIM'], ['CDH2', 'COMPLEX:P05412_P17275', 'VIM'], ['CDH2', 'COMPLEX:P01100_P17275', 'VIM'], ['CDH2', 'NFKB1', 'VIM'], ['CDH2', 'COMPLEX:P19838_Q04206', 'VIM'], ['CDH2', 'JUND', 'VIM'], ['CDH2', 'COMPLEX:P19838_Q00653', 'VIM'], ['CDH2', 'REL', 'VIM'], ['CDH2', 'COMPLEX:Q01201_Q04206', 'VIM'], ['CDH2', 'COMPLEX:Q01201_Q04864', 'VIM'], ['CDH2', 'NFKB2', 'VIM'], ['CDH2', 'RELB', 'VIM'], ['CDH2', 'COMPLEX:P05412_P15408', 'VIM'], ['CDH2', 'COMPLEX:P19838_Q04864', 'VIM'], ['CDH2', 'COMPLEX:Q00653_Q01201', 'VIM'], ['CDH2', 'COMPLEX:P01100_P05412', 'VIM'], ['CDH2', 'COMPLEX:P17535_P53539', 'VIM'], ['CDH2', 'COMPLEX:P15408_P17535', 'VIM'], ['CDH2', 'JUN', 'VIM'], ['CDH2', 'JUNB', 'VIM'], ['CDH2', 'RELA', 'VIM'], ['CDH2', 'COMPLEX:Q00653_Q04206', 'VIM'], ['CDH2', 'COMPLEX:P19838_Q01201', 'VIM'], ['CDH2', 'COMPLEX:P15408_P17275', 'VIM'], ['CDH2', 'COMPLEX:P01100_P17535', 'VIM'], ['CDH2', 'COMPLEX:Q04206_Q04864', 'VIM'], ['CDH2', 'COMPLEX:P15407_P17535', 'VIM'], ['CDH2', 'COMPLEX:P17275_P17535', 'VIM'], ['CDH2', 'COMPLEX:Q00653_Q04864', 'VIM']]\n", + "looking for paths in the network with length: 0 for node CDH2 and MAP4K4\n", + "looking for paths in the network with length: 1 for node CDH2 and MAP4K4\n", + "looking for paths in the network with length: 2 for node CDH2 and MAP4K4\n", + "Found a path!\n", + "[['CDH2', 'PPARG', 'MAP4K4']]\n", + "looking for paths in the network with length: 0 for node CDH2 and PTK2B\n", + "looking for paths in the network with length: 1 for node CDH2 and PTK2B\n", + "looking for paths in the network with length: 2 for node CDH2 and PTK2B\n", + "Found a path!\n", + "[['CDH2', 'COMPLEX:P15407_P17275', 'PTK2B'], ['CDH2', 'COMPLEX:P05412_P53539', 'PTK2B'], ['CDH2', 'COMPLEX:P05412_P17535', 'PTK2B'], ['CDH2', 'COMPLEX:P17275_P53539', 'PTK2B'], ['CDH2', 'COMPLEX:P05412_P15407', 'PTK2B'], ['CDH2', 'COMPLEX:P05412_P17275', 'PTK2B'], ['CDH2', 'COMPLEX:P01100_P17275', 'PTK2B'], ['CDH2', 'JUND', 'PTK2B'], ['CDH2', 'COMPLEX:P05412_P15408', 'PTK2B'], ['CDH2', 'COMPLEX:P01100_P05412', 'PTK2B'], ['CDH2', 'COMPLEX:P17535_P53539', 'PTK2B'], ['CDH2', 'SRC', 'PTK2B'], ['CDH2', 'COMPLEX:P15408_P17535', 'PTK2B'], ['CDH2', 'JUN', 'PTK2B'], ['CDH2', 'JUNB', 'PTK2B'], ['CDH2', 'COMPLEX:P15408_P17275', 'PTK2B'], ['CDH2', 'COMPLEX:P01100_P17535', 'PTK2B'], ['CDH2', 'COMPLEX:P15407_P17535', 'PTK2B'], ['CDH2', 'COMPLEX:P17275_P17535', 'PTK2B']]\n", + "looking for paths in the network with length: 0 for node CDH2 and COL1A1\n", + "looking for paths in the network with length: 1 for node CDH2 and COL1A1\n", + "looking for paths in the network with length: 2 for node CDH2 and COL1A1\n", + "Found a path!\n", + "[['CDH2', 'SRC', 'COL1A1'], ['CDH2', 'NOTCH1', 'COL1A1']]\n", + "looking for paths in the network with length: 0 for node VIM and MAP4K4\n", + "looking for paths in the network with length: 1 for node VIM and MAP4K4\n", + "looking for paths in the network with length: 2 for node VIM and MAP4K4\n", + "looking for paths in the network with length: 3 for node VIM and MAP4K4\n", + "Found a path!\n", + "[['VIM', 'STAT5A', 'PPARG', 'MAP4K4'], ['VIM', 'COMPLEX:P15407_P17275', 'PPARG', 'MAP4K4'], ['VIM', 'COMPLEX:P05412_P53539', 'PPARG', 'MAP4K4'], ['VIM', 'COMPLEX:P05412_P17535', 'PPARG', 'MAP4K4'], ['VIM', 'COMPLEX:P17275_P53539', 'PPARG', 'MAP4K4'], ['VIM', 'COMPLEX:P05412_P15407', 'PPARG', 'MAP4K4'], ['VIM', 'COMPLEX:P05412_P17275', 'PPARG', 'MAP4K4'], ['VIM', 'COMPLEX:P01100_P17275', 'PPARG', 'MAP4K4'], ['VIM', 'NFKB1', 'PPARG', 'MAP4K4'], ['VIM', 'COMPLEX:P19838_Q04206', 'PPARG', 'MAP4K4'], ['VIM', 'JUND', 'PPARG', 'MAP4K4'], ['VIM', 'COMPLEX:P19838_Q00653', 'PPARG', 'MAP4K4'], ['VIM', 'REL', 'PPARG', 'MAP4K4'], ['VIM', 'NFKB1', 'MAP3K2', 'MAP4K4'], ['VIM', 'NFKB1', 'PPARG', 'MAP4K4'], ['VIM', 'COMPLEX:Q01201_Q04206', 'PPARG', 'MAP4K4'], ['VIM', 'COMPLEX:Q01201_Q04864', 'PPARG', 'MAP4K4'], ['VIM', 'NFKB2', 'PPARG', 'MAP4K4'], ['VIM', 'RELB', 'PPARG', 'MAP4K4'], ['VIM', 'COMPLEX:P05412_P15408', 'PPARG', 'MAP4K4'], ['VIM', 'COMPLEX:P19838_Q04864', 'PPARG', 'MAP4K4'], ['VIM', 'COMPLEX:Q00653_Q01201', 'PPARG', 'MAP4K4'], ['VIM', 'COMPLEX:P01100_P05412', 'PPARG', 'MAP4K4'], ['VIM', 'COMPLEX:P17535_P53539', 'PPARG', 'MAP4K4'], ['VIM', 'COMPLEX:P15408_P17535', 'PPARG', 'MAP4K4'], ['VIM', 'JUN', 'PPARG', 'MAP4K4'], ['VIM', 'JUNB', 'PPARG', 'MAP4K4'], ['VIM', 'RELA', 'PPARG', 'MAP4K4'], ['VIM', 'SP1', 'EPHB1', 'MAP4K4'], ['VIM', 'SP1', 'PPARG', 'MAP4K4'], ['VIM', 'COMPLEX:Q00653_Q04206', 'PPARG', 'MAP4K4'], ['VIM', 'COMPLEX:P19838_Q01201', 'PPARG', 'MAP4K4'], ['VIM', 'COMPLEX:P15408_P17275', 'PPARG', 'MAP4K4'], ['VIM', 'COMPLEX:P01100_P17535', 'PPARG', 'MAP4K4'], ['VIM', 'COMPLEX:Q04206_Q04864', 'PPARG', 'MAP4K4'], ['VIM', 'COMPLEX:P15407_P17535', 'PPARG', 'MAP4K4'], ['VIM', 'COMPLEX:P17275_P17535', 'PPARG', 'MAP4K4'], ['VIM', 'COMPLEX:Q00653_Q04864', 'PPARG', 'MAP4K4']]\n", + "looking for paths in the network with length: 0 for node VIM and PTK2B\n", + "looking for paths in the network with length: 1 for node VIM and PTK2B\n", + "looking for paths in the network with length: 2 for node VIM and PTK2B\n", + "Found a path!\n", + "[['VIM', 'COMPLEX:P15407_P17275', 'PTK2B'], ['VIM', 'COMPLEX:P05412_P53539', 'PTK2B'], ['VIM', 'COMPLEX:P05412_P17535', 'PTK2B'], ['VIM', 'COMPLEX:P17275_P53539', 'PTK2B'], ['VIM', 'COMPLEX:P05412_P15407', 'PTK2B'], ['VIM', 'COMPLEX:P05412_P17275', 'PTK2B'], ['VIM', 'COMPLEX:P01100_P17275', 'PTK2B'], ['VIM', 'JUND', 'PTK2B'], ['VIM', 'COMPLEX:P05412_P15408', 'PTK2B'], ['VIM', 'COMPLEX:P01100_P05412', 'PTK2B'], ['VIM', 'COMPLEX:P17535_P53539', 'PTK2B'], ['VIM', 'COMPLEX:P15408_P17535', 'PTK2B'], ['VIM', 'JUN', 'PTK2B'], ['VIM', 'JUNB', 'PTK2B'], ['VIM', 'COMPLEX:P15408_P17275', 'PTK2B'], ['VIM', 'COMPLEX:P01100_P17535', 'PTK2B'], ['VIM', 'COMPLEX:P15407_P17535', 'PTK2B'], ['VIM', 'COMPLEX:P17275_P17535', 'PTK2B']]\n", + "looking for paths in the network with length: 0 for node VIM and COL1A1\n", + "looking for paths in the network with length: 1 for node VIM and COL1A1\n", + "looking for paths in the network with length: 2 for node VIM and COL1A1\n", + "Found a path!\n", + "[['VIM', 'SP3', 'COL1A1'], ['VIM', 'NFKB1', 'COL1A1'], ['VIM', 'SP1', 'COL1A1']]\n", + "looking for paths in the network with length: 0 for node MAP4K4 and PTK2B\n", + "looking for paths in the network with length: 1 for node MAP4K4 and PTK2B\n", + "looking for paths in the network with length: 2 for node MAP4K4 and PTK2B\n" + ] + }, + { + "name": "stdout", + "output_type": "stream", + "text": [ + "looking for paths in the network with length: 3 for node MAP4K4 and PTK2B\n", + "Found a path!\n", + "[['MAP4K4', 'EPHB1', 'PTK2', 'PTK2B'], ['MAP4K4', 'EPHB1', 'SRC', 'PTK2B'], ['MAP4K4', 'PPARG', 'COMPLEX:P15407_P17275', 'PTK2B'], ['MAP4K4', 'PPARG', 'COMPLEX:P05412_P53539', 'PTK2B'], ['MAP4K4', 'PPARG', 'COMPLEX:P05412_P17535', 'PTK2B'], ['MAP4K4', 'PPARG', 'COMPLEX:P17275_P53539', 'PTK2B'], ['MAP4K4', 'PPARG', 'COMPLEX:P05412_P15407', 'PTK2B'], ['MAP4K4', 'PPARG', 'COMPLEX:P05412_P17275', 'PTK2B'], ['MAP4K4', 'PPARG', 'COMPLEX:P01100_P17275', 'PTK2B'], ['MAP4K4', 'PPARG', 'JUND', 'PTK2B'], ['MAP4K4', 'PPARG', 'COMPLEX:P05412_P15408', 'PTK2B'], ['MAP4K4', 'PPARG', 'COMPLEX:P01100_P05412', 'PTK2B'], ['MAP4K4', 'PPARG', 'COMPLEX:P17535_P53539', 'PTK2B'], ['MAP4K4', 'PPARG', 'SRC', 'PTK2B'], ['MAP4K4', 'PPARG', 'COMPLEX:P15408_P17535', 'PTK2B'], ['MAP4K4', 'PPARG', 'JUN', 'PTK2B'], ['MAP4K4', 'PPARG', 'JUNB', 'PTK2B'], ['MAP4K4', 'PPARG', 'COMPLEX:P15408_P17275', 'PTK2B'], ['MAP4K4', 'PPARG', 'COMPLEX:P01100_P17535', 'PTK2B'], ['MAP4K4', 'PPARG', 'COMPLEX:P15407_P17535', 'PTK2B'], ['MAP4K4', 'PPARG', 'COMPLEX:P17275_P17535', 'PTK2B'], ['MAP4K4', 'MAP3K2', 'SRC', 'PTK2B']]\n", + "looking for paths in the network with length: 0 for node MAP4K4 and COL1A1\n", + "looking for paths in the network with length: 1 for node MAP4K4 and COL1A1\n", + "looking for paths in the network with length: 2 for node MAP4K4 and COL1A1\n", + "looking for paths in the network with length: 3 for node MAP4K4 and COL1A1\n", + "Found a path!\n", + "[['MAP4K4', 'EPHB1', 'SP1', 'COL1A1'], ['MAP4K4', 'EPHB1', 'SRC', 'COL1A1'], ['MAP4K4', 'PPARG', 'NFKB1', 'COL1A1'], ['MAP4K4', 'PPARG', 'SRC', 'COL1A1'], ['MAP4K4', 'PPARG', 'NOTCH1', 'COL1A1'], ['MAP4K4', 'PPARG', 'SP1', 'COL1A1'], ['MAP4K4', 'MAP3K2', 'NFKB1', 'COL1A1'], ['MAP4K4', 'MAP3K2', 'SRC', 'COL1A1']]\n", + "looking for paths in the network with length: 0 for node PTK2B and COL1A1\n", + "looking for paths in the network with length: 1 for node PTK2B and COL1A1\n", + "looking for paths in the network with length: 2 for node PTK2B and COL1A1\n", + "Found a path!\n", + "[['PTK2B', 'SRC', 'COL1A1']]\n", + "CPU times: user 2min 4s, sys: 36.8 ms, total: 2min 4s\n", + "Wall time: 2min 4s\n" + ] + } + ], + "source": [ + "%%time\n", + "new_net1.complete_connection(mode=\"ALL\", maxlen=6, k_mean=\"tight\", only_signed=True,\n", + " consensus=True, connect_node_when_first_introduced=True)" + ] + }, + { + "cell_type": "code", + "execution_count": 17, + "id": "db61c89d", + "metadata": {}, + "outputs": [ + { + "data": { + "image/svg+xml": [ + "\n", + "\n", + "\n", + "\n", + "\n", + "\n", + "%3\n", + "\n", + "\n", + "\n", + "SRC\n", + "\n", + "SRC\n", + "\n", + "\n", + "\n", + "PTK2\n", + "\n", + "PTK2\n", + "\n", + "\n", + "\n", + "SRC->PTK2\n", + "\n", + "\n", + "\n", + "\n", + "\n", + "CDH2\n", + "\n", + "CDH2\n", + "\n", + "\n", + "\n", + "SRC->CDH2\n", + "\n", + "\n", + "\n", + "\n", + "\n", + "\n", + "PTK2B\n", + "\n", + "PTK2B\n", + "\n", + "\n", + "\n", + "SRC->PTK2B\n", + "\n", + "\n", 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"Q04206_Q04864->NFKB1\n", + "\n", + "\n", + "\n", + "\n", + "\n", + "Q04206_Q04864->SP1\n", + "\n", + "\n", + "\n", + "\n", + "\n", + "Q04206_Q04864->SP3\n", + "\n", + "\n", + "\n", + "\n", + "\n", + "Q04206_Q04864->STAT5A\n", + "\n", + "\n", + "\n", + "\n", + "\n", + "Q04206_Q04864->HNF4A\n", + "\n", + "\n", + "\n", + "\n", + "\n", + "\n", + "Q04206_Q04864->PPARG\n", + "\n", + "\n", + "\n", + "\n", + "\n", + "\n", + "HIPK2->VIM\n", + "\n", + "\n", + "\n", + "\n", + "\n", + "\n", + "Q01201_Q04864\n", + "\n", + "Q01201_Q04864\n", + "\n", + "\n", + "\n", + "Q01201_Q04864->SRC\n", + "\n", + "\n", + "\n", + "\n", + "\n", + "Q01201_Q04864->PTK2\n", + "\n", + "\n", + "\n", + "\n", + "\n", + "Q01201_Q04864->CDH1\n", + "\n", + "\n", + "\n", + "\n", + "\n", + "Q01201_Q04864->CDH2\n", + "\n", + "\n", + "\n", + "\n", + "\n", + "Q01201_Q04864->NOTCH1\n", + "\n", + "\n", + "\n", + "\n", + "\n", + "Q01201_Q04864->VIM\n", + "\n", + "\n", + "\n", + "\n", + "\n", + "Q01201_Q04864->NFKB1\n", + "\n", + "\n", + "\n", + "\n", + "\n", + "Q01201_Q04864->SP1\n", + "\n", + "\n", + "\n", + "\n", + "\n", + "Q01201_Q04864->SP3\n", + "\n", + "\n", + "\n", + "\n", + "\n", + "Q01201_Q04864->STAT5A\n", + "\n", + "\n", + "\n", + "\n", + "\n", + "Q01201_Q04864->HNF4A\n", + "\n", + "\n", + "\n", + "\n", + "\n", + "\n", + "Q01201_Q04864->PPARG\n", + "\n", + "\n", + "\n", + "\n", + "\n", + "\n", + "NFKB2\n", + "\n", + "NFKB2\n", + "\n", + "\n", + "\n", + "NFKB2->SRC\n", + "\n", + "\n", + "\n", + "\n", + "\n", + "NFKB2->PTK2\n", + "\n", + "\n", + "\n", + "\n", + "\n", + "NFKB2->CDH1\n", + "\n", + "\n", + "\n", + "\n", + "\n", + "NFKB2->CDH2\n", + "\n", + "\n", + "\n", + "\n", + "\n", + "NFKB2->NOTCH1\n", + "\n", + "\n", + "\n", + "\n", + "\n", + "NFKB2->VIM\n", + "\n", + "\n", + "\n", + "\n", + "\n", + "NFKB2->NFKB1\n", + "\n", + "\n", + "\n", + "\n", + "\n", + "NFKB2->SP1\n", + "\n", + "\n", + "\n", + "\n", + "\n", + "NFKB2->SP3\n", + "\n", + "\n", + "\n", + "\n", + "\n", + "NFKB2->STAT5A\n", + "\n", + "\n", + "\n", + "\n", + "\n", + "NFKB2->HNF4A\n", + "\n", + "\n", + "\n", + "\n", + "\n", + "\n", + "NFKB2->PPARG\n", + "\n", + "\n", + "\n", + "\n", + "\n", + "\n", + "Q00653_Q04864\n", + "\n", + "Q00653_Q04864\n", + "\n", + "\n", + "\n", + "Q00653_Q04864->SRC\n", + "\n", + "\n", + "\n", + "\n", + "\n", + "Q00653_Q04864->PTK2\n", + "\n", + "\n", + "\n", + "\n", + "\n", + "Q00653_Q04864->CDH1\n", + "\n", + "\n", + "\n", + "\n", + "\n", + "Q00653_Q04864->CDH2\n", + "\n", + "\n", + "\n", + "\n", + "\n", + "Q00653_Q04864->NOTCH1\n", + "\n", + "\n", + "\n", + "\n", + "\n", + "Q00653_Q04864->VIM\n", + "\n", + "\n", + "\n", + "\n", + "\n", + "Q00653_Q04864->NFKB1\n", + "\n", + "\n", + "\n", + "\n", + "\n", + "Q00653_Q04864->SP1\n", + "\n", + "\n", + "\n", + "\n", + "\n", + "Q00653_Q04864->SP3\n", + "\n", + "\n", + "\n", + "\n", + "\n", + "Q00653_Q04864->STAT5A\n", + "\n", + "\n", + "\n", + "\n", + "\n", + "Q00653_Q04864->HNF4A\n", + "\n", + "\n", + "\n", + "\n", + "\n", + "\n", + "Q00653_Q04864->PPARG\n", + "\n", + "\n", + "\n", + "\n", + "\n", + "\n", + "Q01201_Q04206\n", + "\n", + "Q01201_Q04206\n", + "\n", + "\n", + "\n", + "Q01201_Q04206->SRC\n", + "\n", + "\n", + "\n", + "\n", + "\n", + "Q01201_Q04206->PTK2\n", + "\n", + "\n", + "\n", + "\n", + "\n", + "Q01201_Q04206->CDH1\n", + "\n", + "\n", + "\n", + "\n", + "\n", + "Q01201_Q04206->CDH2\n", + "\n", + "\n", + "\n", + "\n", + "\n", + "Q01201_Q04206->NOTCH1\n", + "\n", + "\n", + "\n", + "\n", + "\n", + "Q01201_Q04206->VIM\n", + "\n", + "\n", + "\n", + "\n", + "\n", + "Q01201_Q04206->NFKB1\n", + "\n", + "\n", + "\n", + "\n", + "\n", + "Q01201_Q04206->SP1\n", + "\n", + "\n", + "\n", + "\n", + "\n", + "Q01201_Q04206->SP3\n", + "\n", + "\n", + "\n", + "\n", + "\n", + "Q01201_Q04206->STAT5A\n", + "\n", + "\n", + "\n", + "\n", + "\n", + "Q01201_Q04206->HNF4A\n", + "\n", + "\n", + "\n", + "\n", + "\n", + "\n", + "Q01201_Q04206->PPARG\n", + "\n", + "\n", + "\n", + "\n", + "\n", + "\n", + "P05412_P15408\n", + "\n", + "P05412_P15408\n", + "\n", + "\n", + "\n", + "P05412_P15408->SRC\n", + "\n", + "\n", + "\n", + "\n", + "\n", + "P05412_P15408->CDH1\n", + "\n", + "\n", + "\n", + "\n", + "\n", + "P05412_P15408->CDH2\n", + "\n", + "\n", + "\n", + "\n", + "\n", + "\n", + "P05412_P15408->PTK2B\n", + "\n", + "\n", + "\n", + "\n", + "\n", + "P05412_P15408->VIM\n", + "\n", + "\n", + "\n", + "\n", + "\n", + "P05412_P15408->NFKB1\n", + "\n", + "\n", + "\n", + "\n", + "\n", + "\n", + "P05412_P15408->SP1\n", + "\n", + "\n", + "\n", + "\n", + "\n", + "P05412_P15408->SP3\n", + "\n", + "\n", + "\n", + "\n", + "\n", + "P05412_P15408->PPARG\n", + "\n", + "\n", + "\n", + "\n", + "\n", + "\n", + "P17275_P17535\n", + "\n", + "P17275_P17535\n", + "\n", + "\n", + "\n", + "P17275_P17535->SRC\n", + "\n", + "\n", + "\n", + "\n", + "\n", + "P17275_P17535->CDH1\n", + "\n", + "\n", + "\n", + "\n", + "\n", + "P17275_P17535->CDH2\n", + "\n", + "\n", + "\n", + "\n", + "\n", + "\n", + "P17275_P17535->PTK2B\n", + "\n", + "\n", + "\n", + "\n", + "\n", + "P17275_P17535->VIM\n", + "\n", + "\n", + "\n", + "\n", + "\n", + "P17275_P17535->NFKB1\n", + "\n", + "\n", + "\n", + "\n", + "\n", + "\n", + "P17275_P17535->SP1\n", + "\n", + "\n", + "\n", + "\n", + "\n", + "P17275_P17535->SP3\n", + "\n", + "\n", + "\n", + "\n", + "\n", + "P17275_P17535->PPARG\n", + "\n", + "\n", + "\n", + "\n", + "\n", + "\n", + "MAP3K2->NFKB1\n", + "\n", + "\n", + "\n", + "\n", + "\n", + "MAP4K4\n", + "\n", + "MAP4K4\n", + "\n", + "\n", + "\n", + "MAP4K4->MAP3K2\n", + "\n", + "\n", + "\n", + "\n", + "\n", + "EPHB1->SRC\n", + "\n", + "\n", + "\n", + "\n", + "\n", + "EPHB1->PTK2\n", + "\n", + "\n", + "\n", + "\n", + "\n", + "\n", + "EPHB1->MAP4K4\n", + "\n", + "\n", + "\n", + "\n", + "\n", + "PPARG->CDH1\n", + "\n", + "\n", + "\n", + "\n", + "\n", + "PPARG->CDH2\n", + "\n", + "\n", + "\n", + "\n", + "\n", + "\n", + "PPARG->NFKB1\n", + "\n", + "\n", + "\n", + "\n", + "\n", + "\n", + "PPARG->SP1\n", + "\n", + "\n", + "\n", + "\n", + "\n", + "PPARG->STAT5A\n", + "\n", + "\n", + "\n", + "\n", + "\n", + "\n", + "PPARG->MAP4K4\n", + "\n", + "\n", + "\n", + "\n", + "\n", + "\n" + ], + "text/plain": [ + "" + ] + }, + "metadata": {}, + "output_type": "display_data" + } + ], + "source": [ + "visualizer = NetworkVisualizer(new_net1, color_by='effect')\n", + "visualizer.render()" + ] + }, + { + "cell_type": "markdown", + "id": "8361d2b2-646b-4080-bc36-ca28c9bfab10", + "metadata": {}, + "source": [ + "## The whole tool, as the name suggest, is based on Omnipath. But the user can also integrate its own databases. As example, we show how to integrate the Signor database. In order to do so, the User needs to have already downloaded the whole Signor database, available at the following link: https://signor.uniroma2.it/downloads.php \n", + "## Omniflow has been conceived to be a modular tool, with the possibility to add new databases. Every time a User wants to add a database, it should prepare an apposite function in the Resources module, in order to convert the target database, in the Omniflow format. We suggest to use as example, the function created for the Signor database. In future releases we plan to add more function to include more databases." + ] + }, + { + "cell_type": "code", + "execution_count": 16, + "id": "4fd4b190-350a-4682-8f09-8c6423064038", + "metadata": {}, + "outputs": [], + "source": [ + "resources = Resources()\n", + "resources.import_signor_tsv(\"./all_data_18_03_24.tsv\") # this function accept only tab separated values" + ] + }, + { + "cell_type": "code", + "execution_count": 23, + "id": "1ee6984a-1a6e-410e-b335-9acc1359b359", + "metadata": {}, + "outputs": [ + { + "name": "stdout", + "output_type": "stream", + "text": [ + "CPU times: user 32.3 ms, sys: 2 µs, total: 32.3 ms\n", + "Wall time: 31.6 ms\n" + ] + } + ], + "source": [ + "%%time\n", + "new_net1 = Network(genes, resources=resources.interactions) # here we load the signor interactions" + ] + }, + { + "cell_type": "markdown", + "id": "7aae5ca7-5696-44ba-9e75-4a2d1eb0a2d9", + "metadata": {}, + "source": [ + "## It is important to note, that not all the databases have the same structure as Omnipath. In particular, if the columns \"consensus\" are missing, we suggest to avoid to use the flag \"consensus\" or \"consensus_only\" when using Omniflow with customize databases." + ] + }, + { + "cell_type": "code", + "execution_count": 24, + "id": "12052b3b-854f-41a0-a762-20de5cbc7b35", + "metadata": {}, + "outputs": [ + { + "name": "stdout", + "output_type": "stream", + "text": [ + "looking for paths in the network with length: 0 for node FOXA1 and GRHL1\n", + "looking for paths in the network with length: 1 for node FOXA1 and GRHL1\n", + "looking for paths in the network with length: 2 for node FOXA1 and GRHL1\n", + "looking for paths in the network with length: 3 for node FOXA1 and GRHL1\n", + "looking for paths in the network with length: 4 for node FOXA1 and GRHL1\n", + "looking for paths in the network with length: 5 for node FOXA1 and GRHL1\n", + "looking for paths in the network with length: 6 for node FOXA1 and GRHL1\n", + "i_search = 3\n", + "Looking for paths with length: 0 for node FOXA1 and GRHL1\n", + "i_search = 3\n", + "Looking for paths with length: 1 for node FOXA1 and GRHL1\n", + "i_search = 3\n", + "Looking for paths with length: 2 for node FOXA1 and GRHL1\n", + "i_search = 3\n", + "Looking for paths with length: 3 for node FOXA1 and GRHL1\n", + "looking for paths in the network with length: 0 for node FOXA1 and GRHL3\n", + "looking for paths in the network with length: 1 for node FOXA1 and GRHL3\n", + "looking for paths in the network with length: 2 for node FOXA1 and GRHL3\n", + "looking for paths in the network with length: 3 for node FOXA1 and GRHL3\n", + "looking for paths in the network with length: 4 for node FOXA1 and GRHL3\n", + "looking for paths in the network with length: 5 for node FOXA1 and GRHL3\n", + "looking for paths in the network with length: 6 for node FOXA1 and GRHL3\n", + "i_search = 3\n", + "Looking for paths with length: 0 for node FOXA1 and GRHL3\n", + "i_search = 3\n", + "Looking for paths with length: 1 for node FOXA1 and GRHL3\n", + "i_search = 3\n", + "Looking for paths with length: 2 for node FOXA1 and GRHL3\n", + "i_search = 3\n", + "Looking for paths with length: 3 for node FOXA1 and GRHL3\n", + "looking for paths in the network with length: 0 for node FOXA1 and EHF\n", + "looking for paths in the network with length: 1 for node FOXA1 and EHF\n", + "looking for paths in the network with length: 2 for node FOXA1 and EHF\n", + "looking for paths in the network with length: 3 for node FOXA1 and EHF\n", + "looking for paths in the network with length: 4 for node FOXA1 and EHF\n", + "looking for paths in the network with length: 5 for node FOXA1 and EHF\n", + "looking for paths in the network with length: 6 for node FOXA1 and EHF\n", + "i_search = 3\n", + "Looking for paths with length: 0 for node FOXA1 and EHF\n", + "i_search = 3\n", + "Looking for paths with length: 1 for node FOXA1 and EHF\n", + "i_search = 3\n", + "Looking for paths with length: 2 for node FOXA1 and EHF\n", + "i_search = 3\n", + "Looking for paths with length: 3 for node FOXA1 and EHF\n", + "looking for paths in the network with length: 0 for node FOXA1 and KLF5\n", + "looking for paths in the network with length: 1 for node FOXA1 and KLF5\n", + "looking for paths in the network with length: 2 for node FOXA1 and KLF5\n", + "looking for paths in the network with length: 3 for node FOXA1 and KLF5\n", + "looking for paths in the network with length: 4 for node FOXA1 and KLF5\n", + "looking for paths in the network with length: 5 for node FOXA1 and KLF5\n", + "looking for paths in the network with length: 6 for node FOXA1 and KLF5\n", + "i_search = 3\n", + "Looking for paths with length: 0 for node FOXA1 and KLF5\n", + "i_search = 3\n", + "Looking for paths with length: 1 for node FOXA1 and KLF5\n", + "i_search = 3\n", + "Looking for paths with length: 2 for node FOXA1 and KLF5\n", + "i_search = 3\n", + "Looking for paths with length: 3 for node FOXA1 and KLF5\n", + "[['FOXA1', 'HSPA1A', 'NR3C1', 'KLF5'], ['FOXA1', 'AR', 'NR3C1', 'KLF5']]\n", + "P55317 P0DMV8\n", + "P0DMV8 P04150\n", + "P04150 Q13887\n", + "P55317 P10275\n", + "P10275 P04150\n", + "P04150 Q13887\n", + "P55317 P0DMV8\n", + "P55317 P10275\n", + "P17676 Q13887\n", + "P04150 Q13887\n", + "P04150 P17676\n", + "P0DMV8 P04150\n", + "P04150 P10275\n", + "P10275 P04150\n", + "looking for paths in the network with length: 0 for node FOXA1 and HOXA9\n", + "looking for paths in the network with length: 1 for node FOXA1 and HOXA9\n", + "looking for paths in the network with length: 2 for node FOXA1 and HOXA9\n", + "looking for paths in the network with length: 3 for node FOXA1 and HOXA9\n", + "looking for paths in the network with length: 4 for node FOXA1 and HOXA9\n", + "looking for paths in the network with length: 5 for node FOXA1 and HOXA9\n", + "looking for paths in the network with length: 6 for node FOXA1 and HOXA9\n", + "i_search = 3\n", + "Looking for paths with length: 0 for node FOXA1 and HOXA9\n", + "i_search = 3\n", + "Looking for paths with length: 1 for node FOXA1 and HOXA9\n", + "i_search = 3\n", + "Looking for paths with length: 2 for node FOXA1 and HOXA9\n", + "i_search = 3\n", + "Looking for paths with length: 3 for node FOXA1 and HOXA9\n", + "[['FOXA1', 'NFIB', 'EZH2', 'HOXA9']]\n", + "P55317 O00712\n", + "O00712 Q15910\n", + "Q15910 P31269\n", + "P55317 P0DMV8\n", + "P55317 P10275\n", + "P55317 O00712\n", + "P17676 Q13887\n", + "P04150 Q13887\n", + "Q15910 P31269\n", + "Q15910 P31260\n", + "O00712 P41161\n", + "P04150 P17676\n", + "P0DMV8 P04150\n", + "P04150 P10275\n", + "P10275 P04150\n", + "Q15910 P10275\n", + "O00712 Q15910\n", + "looking for paths in the network with length: 0 for node FOXA1 and HOXA10\n", + "looking for paths in the network with length: 1 for node FOXA1 and HOXA10\n", + "looking for paths in the network with length: 2 for node FOXA1 and HOXA10\n", + "looking for paths in the network with length: 3 for node FOXA1 and HOXA10\n", + "Found a path!\n", + "[['FOXA1', 'NFIB', 'EZH2', 'HOXA10']]\n", + "looking for paths in the network with length: 0 for node FOXA1 and ETV4\n", + "looking for paths in the network with length: 1 for node FOXA1 and ETV4\n", + "looking for paths in the network with length: 2 for node FOXA1 and ETV4\n", + "looking for paths in the network with length: 3 for node FOXA1 and ETV4\n", + "looking for paths in the network with length: 4 for node FOXA1 and ETV4\n", + "looking for paths in the network with length: 5 for node FOXA1 and ETV4\n", + "looking for paths in the network with length: 6 for node FOXA1 and ETV4\n", + "i_search = 3\n", + "Looking for paths with length: 0 for node FOXA1 and ETV4\n", + "i_search = 3\n", + "Looking for paths with length: 1 for node FOXA1 and ETV4\n", + "i_search = 3\n", + "Looking for paths with length: 2 for node FOXA1 and ETV4\n", + "i_search = 3\n", + "Looking for paths with length: 3 for node FOXA1 and ETV4\n", + "looking for paths in the network with length: 0 for node FOXA1 and ETV5\n", + "looking for paths in the network with length: 1 for node FOXA1 and ETV5\n", + "looking for paths in the network with length: 2 for node FOXA1 and ETV5\n", + "Found a path!\n", + "[['FOXA1', 'NFIB', 'ETV5']]\n", + "looking for paths in the network with length: 0 for node FOXA1 and POU3F1\n", + "looking for paths in the network with length: 1 for node FOXA1 and POU3F1\n", + "looking for paths in the network with length: 2 for node FOXA1 and POU3F1\n", + "looking for paths in the network with length: 3 for node FOXA1 and POU3F1\n", + "looking for paths in the network with length: 4 for node FOXA1 and POU3F1\n", + "looking for paths in the network with length: 5 for node FOXA1 and POU3F1\n", + "looking for paths in the network with length: 6 for node FOXA1 and POU3F1\n", + "i_search = 3\n", + "Looking for paths with length: 0 for node FOXA1 and POU3F1\n", + "i_search = 3\n", + "Looking for paths with length: 1 for node FOXA1 and POU3F1\n", + "i_search = 3\n", + "Looking for paths with length: 2 for node FOXA1 and POU3F1\n", + "i_search = 3\n", + "Looking for paths with length: 3 for node FOXA1 and POU3F1\n", + "looking for paths in the network with length: 0 for node FOXA1 and CEBPB\n", + "looking for paths in the network with length: 1 for node FOXA1 and CEBPB\n", + "looking for paths in the network with length: 2 for node FOXA1 and CEBPB\n", + "looking for paths in the network with length: 3 for node FOXA1 and CEBPB\n", + "Found a path!\n", + "[['FOXA1', 'HSPA1A', 'NR3C1', 'CEBPB'], ['FOXA1', 'AR', 'NR3C1', 'CEBPB']]\n", + "looking for paths in the network with length: 0 for node GRHL1 and GRHL3\n", + "looking for paths in the network with length: 1 for node GRHL1 and GRHL3\n", + "looking for paths in the network with length: 2 for node GRHL1 and GRHL3\n", + "looking for paths in the network with length: 3 for node GRHL1 and GRHL3\n", + "looking for paths in the network with length: 4 for node GRHL1 and GRHL3\n", + "looking for paths in the network with length: 5 for node GRHL1 and GRHL3\n", + "looking for paths in the network with length: 6 for node GRHL1 and GRHL3\n", + "i_search = 3\n", + "Looking for paths with length: 0 for node GRHL1 and GRHL3\n", + "i_search = 3\n", + "Looking for paths with length: 1 for node GRHL1 and GRHL3\n", + "i_search = 3\n", + "Looking for paths with length: 2 for node GRHL1 and GRHL3\n", + "i_search = 3\n", + "Looking for paths with length: 3 for node GRHL1 and GRHL3\n", + "looking for paths in the network with length: 0 for node GRHL1 and EHF\n", + "looking for paths in the network with length: 1 for node GRHL1 and EHF\n", + "looking for paths in the network with length: 2 for node GRHL1 and EHF\n", + "looking for paths in the network with length: 3 for node GRHL1 and EHF\n", + "looking for paths in the network with length: 4 for node GRHL1 and EHF\n", + "looking for paths in the network with length: 5 for node GRHL1 and EHF\n", + "looking for paths in the network with length: 6 for node GRHL1 and EHF\n", + "i_search = 3\n", + "Looking for paths with length: 0 for node GRHL1 and EHF\n", + "i_search = 3\n", + "Looking for paths with length: 1 for node GRHL1 and EHF\n", + "i_search = 3\n", + "Looking for paths with length: 2 for node GRHL1 and EHF\n", + "i_search = 3\n", + "Looking for paths with length: 3 for node GRHL1 and EHF\n", + "looking for paths in the network with length: 0 for node GRHL1 and KLF5\n", + "looking for paths in the network with length: 1 for node GRHL1 and KLF5\n", + "looking for paths in the network with length: 2 for node GRHL1 and KLF5\n", + "looking for paths in the network with length: 3 for node GRHL1 and KLF5\n", + "looking for paths in the network with length: 4 for node GRHL1 and KLF5\n", + "looking for paths in the network with length: 5 for node GRHL1 and KLF5\n", + "looking for paths in the network with length: 6 for node GRHL1 and KLF5\n", + "i_search = 3\n", + "Looking for paths with length: 0 for node GRHL1 and KLF5\n", + "i_search = 3\n", + "Looking for paths with length: 1 for node GRHL1 and KLF5\n", + "i_search = 3\n", + "Looking for paths with length: 2 for node GRHL1 and KLF5\n", + "i_search = 3\n", + "Looking for paths with length: 3 for node GRHL1 and KLF5\n", + "looking for paths in the network with length: 0 for node GRHL1 and HOXA9\n", + "looking for paths in the network with length: 1 for node GRHL1 and HOXA9\n", + "looking for paths in the network with length: 2 for node GRHL1 and HOXA9\n", + "looking for paths in the network with length: 3 for node GRHL1 and HOXA9\n", + "looking for paths in the network with length: 4 for node GRHL1 and HOXA9\n", + "looking for paths in the network with length: 5 for node GRHL1 and HOXA9\n", + "looking for paths in the network with length: 6 for node GRHL1 and HOXA9\n", + "i_search = 3\n", + "Looking for paths with length: 0 for node GRHL1 and HOXA9\n", + "i_search = 3\n", + "Looking for paths with length: 1 for node GRHL1 and HOXA9\n", + "i_search = 3\n", + "Looking for paths with length: 2 for node GRHL1 and HOXA9\n", + "i_search = 3\n", + "Looking for paths with length: 3 for node GRHL1 and HOXA9\n", + "looking for paths in the network with length: 0 for node GRHL1 and HOXA10\n", + "looking for paths in the network with length: 1 for node GRHL1 and HOXA10\n", + "looking for paths in the network with length: 2 for node GRHL1 and HOXA10\n", + "looking for paths in the network with length: 3 for node GRHL1 and HOXA10\n", + "looking for paths in the network with length: 4 for node GRHL1 and HOXA10\n", + "looking for paths in the network with length: 5 for node GRHL1 and HOXA10\n", + "looking for paths in the network with length: 6 for node GRHL1 and HOXA10\n", + "i_search = 3\n", + "Looking for paths with length: 0 for node GRHL1 and HOXA10\n", + "i_search = 3\n", + "Looking for paths with length: 1 for node GRHL1 and HOXA10\n", + "i_search = 3\n", + "Looking for paths with length: 2 for node GRHL1 and HOXA10\n", + "i_search = 3\n", + "Looking for paths with length: 3 for node GRHL1 and HOXA10\n", + "looking for paths in the network with length: 0 for node GRHL1 and ETV4\n", + "looking for paths in the network with length: 1 for node GRHL1 and ETV4\n", + "looking for paths in the network with length: 2 for node GRHL1 and ETV4\n", + "looking for paths in the network with length: 3 for node GRHL1 and ETV4\n", + "looking for paths in the network with length: 4 for node GRHL1 and ETV4\n", + "looking for paths in the network with length: 5 for node GRHL1 and ETV4\n", + "looking for paths in the network with length: 6 for node GRHL1 and ETV4\n", + "i_search = 3\n", + "Looking for paths with length: 0 for node GRHL1 and ETV4\n", + "i_search = 3\n", + "Looking for paths with length: 1 for node GRHL1 and ETV4\n", + "i_search = 3\n", + "Looking for paths with length: 2 for node GRHL1 and ETV4\n", + "i_search = 3\n", + "Looking for paths with length: 3 for node GRHL1 and ETV4\n", + "looking for paths in the network with length: 0 for node GRHL1 and ETV5\n", + "looking for paths in the network with length: 1 for node GRHL1 and ETV5\n", + "looking for paths in the network with length: 2 for node GRHL1 and ETV5\n", + "looking for paths in the network with length: 3 for node GRHL1 and ETV5\n", + "looking for paths in the network with length: 4 for node GRHL1 and ETV5\n", + "looking for paths in the network with length: 5 for node GRHL1 and ETV5\n", + "looking for paths in the network with length: 6 for node GRHL1 and ETV5\n", + "i_search = 3\n", + "Looking for paths with length: 0 for node GRHL1 and ETV5\n", + "i_search = 3\n", + "Looking for paths with length: 1 for node GRHL1 and ETV5\n", + "i_search = 3\n", + "Looking for paths with length: 2 for node GRHL1 and ETV5\n", + "i_search = 3\n", + "Looking for paths with length: 3 for node GRHL1 and ETV5\n", + "looking for paths in the network with length: 0 for node GRHL1 and POU3F1\n", + "looking for paths in the network with length: 1 for node GRHL1 and POU3F1\n", + "looking for paths in the network with length: 2 for node GRHL1 and POU3F1\n", + "looking for paths in the network with length: 3 for node GRHL1 and POU3F1\n", + "looking for paths in the network with length: 4 for node GRHL1 and POU3F1\n", + "looking for paths in the network with length: 5 for node GRHL1 and POU3F1\n", + "looking for paths in the network with length: 6 for node GRHL1 and POU3F1\n", + "i_search = 3\n", + "Looking for paths with length: 0 for node GRHL1 and POU3F1\n", + "i_search = 3\n", + "Looking for paths with length: 1 for node GRHL1 and POU3F1\n", + "i_search = 3\n", + "Looking for paths with length: 2 for node GRHL1 and POU3F1\n", + "i_search = 3\n", + "Looking for paths with length: 3 for node GRHL1 and POU3F1\n", + "looking for paths in the network with length: 0 for node GRHL1 and CEBPB\n", + "looking for paths in the network with length: 1 for node GRHL1 and CEBPB\n", + "looking for paths in the network with length: 2 for node GRHL1 and CEBPB\n", + "looking for paths in the network with length: 3 for node GRHL1 and CEBPB\n", + "looking for paths in the network with length: 4 for node GRHL1 and CEBPB\n", + "looking for paths in the network with length: 5 for node GRHL1 and CEBPB\n", + "looking for paths in the network with length: 6 for node GRHL1 and CEBPB\n", + "i_search = 3\n", + "Looking for paths with length: 0 for node GRHL1 and CEBPB\n", + "i_search = 3\n", + "Looking for paths with length: 1 for node GRHL1 and CEBPB\n", + "i_search = 3\n", + "Looking for paths with length: 2 for node GRHL1 and CEBPB\n", + "i_search = 3\n", + "Looking for paths with length: 3 for node GRHL1 and CEBPB\n", + "looking for paths in the network with length: 0 for node GRHL3 and EHF\n", + "looking for paths in the network with length: 1 for node GRHL3 and EHF\n", + "looking for paths in the network with length: 2 for node GRHL3 and EHF\n", + "looking for paths in the network with length: 3 for node GRHL3 and EHF\n", + "looking for paths in the network with length: 4 for node GRHL3 and EHF\n", + "looking for paths in the network with length: 5 for node GRHL3 and EHF\n", + "looking for paths in the network with length: 6 for node GRHL3 and EHF\n", + "i_search = 3\n", + "Looking for paths with length: 0 for node GRHL3 and EHF\n", + "i_search = 3\n", + "Looking for paths with length: 1 for node GRHL3 and EHF\n", + "i_search = 3\n", + "Looking for paths with length: 2 for node GRHL3 and EHF\n", + "i_search = 3\n", + "Looking for paths with length: 3 for node GRHL3 and EHF\n", + "looking for paths in the network with length: 0 for node GRHL3 and KLF5\n", + "looking for paths in the network with length: 1 for node GRHL3 and KLF5\n", + "looking for paths in the network with length: 2 for node GRHL3 and KLF5\n", + "looking for paths in the network with length: 3 for node GRHL3 and KLF5\n", + "looking for paths in the network with length: 4 for node GRHL3 and KLF5\n", + "looking for paths in the network with length: 5 for node GRHL3 and KLF5\n", + "looking for paths in the network with length: 6 for node GRHL3 and KLF5\n", + "i_search = 3\n", + "Looking for paths with length: 0 for node GRHL3 and KLF5\n", + "i_search = 3\n", + "Looking for paths with length: 1 for node GRHL3 and KLF5\n", + "i_search = 3\n", + "Looking for paths with length: 2 for node GRHL3 and KLF5\n", + "i_search = 3\n", + "Looking for paths with length: 3 for node GRHL3 and KLF5\n", + "looking for paths in the network with length: 0 for node GRHL3 and HOXA9\n", + "looking for paths in the network with length: 1 for node GRHL3 and HOXA9\n", + "looking for paths in the network with length: 2 for node GRHL3 and HOXA9\n", + "looking for paths in the network with length: 3 for node GRHL3 and HOXA9\n", + "looking for paths in the network with length: 4 for node GRHL3 and HOXA9\n", + "looking for paths in the network with length: 5 for node GRHL3 and HOXA9\n", + "looking for paths in the network with length: 6 for node GRHL3 and HOXA9\n", + "i_search = 3\n", + "Looking for paths with length: 0 for node GRHL3 and HOXA9\n", + "i_search = 3\n", + "Looking for paths with length: 1 for node GRHL3 and HOXA9\n", + "i_search = 3\n", + "Looking for paths with length: 2 for node GRHL3 and HOXA9\n", + "i_search = 3\n", + "Looking for paths with length: 3 for node GRHL3 and HOXA9\n", + "looking for paths in the network with length: 0 for node GRHL3 and HOXA10\n", + "looking for paths in the network with length: 1 for node GRHL3 and HOXA10\n", + "looking for paths in the network with length: 2 for node GRHL3 and HOXA10\n", + "looking for paths in the network with length: 3 for node GRHL3 and HOXA10\n", + "looking for paths in the network with length: 4 for node GRHL3 and HOXA10\n", + "looking for paths in the network with length: 5 for node GRHL3 and HOXA10\n", + "looking for paths in the network with length: 6 for node GRHL3 and HOXA10\n", + "i_search = 3\n", + "Looking for paths with length: 0 for node GRHL3 and HOXA10\n", + "i_search = 3\n", + "Looking for paths with length: 1 for node GRHL3 and HOXA10\n", + "i_search = 3\n", + "Looking for paths with length: 2 for node GRHL3 and HOXA10\n", + "i_search = 3\n", + "Looking for paths with length: 3 for node GRHL3 and HOXA10\n", + "looking for paths in the network with length: 0 for node GRHL3 and ETV4\n", + "looking for paths in the network with length: 1 for node GRHL3 and ETV4\n", + "looking for paths in the network with length: 2 for node GRHL3 and ETV4\n", + "looking for paths in the network with length: 3 for node GRHL3 and ETV4\n", + "looking for paths in the network with length: 4 for node GRHL3 and ETV4\n", + "looking for paths in the network with length: 5 for node GRHL3 and ETV4\n", + "looking for paths in the network with length: 6 for node GRHL3 and ETV4\n", + "i_search = 3\n", + "Looking for paths with length: 0 for node GRHL3 and ETV4\n", + "i_search = 3\n", + "Looking for paths with length: 1 for node GRHL3 and ETV4\n", + "i_search = 3\n", + "Looking for paths with length: 2 for node GRHL3 and ETV4\n", + "i_search = 3\n", + "Looking for paths with length: 3 for node GRHL3 and ETV4\n", + "looking for paths in the network with length: 0 for node GRHL3 and ETV5\n", + "looking for paths in the network with length: 1 for node GRHL3 and ETV5\n", + "looking for paths in the network with length: 2 for node GRHL3 and ETV5\n", + "looking for paths in the network with length: 3 for node GRHL3 and ETV5\n", + "looking for paths in the network with length: 4 for node GRHL3 and ETV5\n", + "looking for paths in the network with length: 5 for node GRHL3 and ETV5\n", + "looking for paths in the network with length: 6 for node GRHL3 and ETV5\n", + "i_search = 3\n", + "Looking for paths with length: 0 for node GRHL3 and ETV5\n", + "i_search = 3\n", + "Looking for paths with length: 1 for node GRHL3 and ETV5\n", + "i_search = 3\n", + "Looking for paths with length: 2 for node GRHL3 and ETV5\n", + "i_search = 3\n", + "Looking for paths with length: 3 for node GRHL3 and ETV5\n", + "looking for paths in the network with length: 0 for node GRHL3 and POU3F1\n", + "looking for paths in the network with length: 1 for node GRHL3 and POU3F1\n", + "looking for paths in the network with length: 2 for node GRHL3 and POU3F1\n", + "looking for paths in the network with length: 3 for node GRHL3 and POU3F1\n", + "looking for paths in the network with length: 4 for node GRHL3 and POU3F1\n", + "looking for paths in the network with length: 5 for node GRHL3 and POU3F1\n", + "looking for paths in the network with length: 6 for node GRHL3 and POU3F1\n", + "i_search = 3\n", + "Looking for paths with length: 0 for node GRHL3 and POU3F1\n", + "i_search = 3\n", + "Looking for paths with length: 1 for node GRHL3 and POU3F1\n", + "i_search = 3\n", + "Looking for paths with length: 2 for node GRHL3 and POU3F1\n", + "i_search = 3\n", + "Looking for paths with length: 3 for node GRHL3 and POU3F1\n", + "looking for paths in the network with length: 0 for node GRHL3 and CEBPB\n", + "looking for paths in the network with length: 1 for node GRHL3 and CEBPB\n", + "looking for paths in the network with length: 2 for node GRHL3 and CEBPB\n", + "looking for paths in the network with length: 3 for node GRHL3 and CEBPB\n", + "looking for paths in the network with length: 4 for node GRHL3 and CEBPB\n", + "looking for paths in the network with length: 5 for node GRHL3 and CEBPB\n", + "looking for paths in the network with length: 6 for node GRHL3 and CEBPB\n", + "i_search = 3\n", + "Looking for paths with length: 0 for node GRHL3 and CEBPB\n", + "i_search = 3\n", + "Looking for paths with length: 1 for node GRHL3 and CEBPB\n", + "i_search = 3\n", + "Looking for paths with length: 2 for node GRHL3 and CEBPB\n", + "i_search = 3\n", + "Looking for paths with length: 3 for node GRHL3 and CEBPB\n", + "looking for paths in the network with length: 0 for node EHF and KLF5\n", + "looking for paths in the network with length: 1 for node EHF and KLF5\n", + "looking for paths in the network with length: 2 for node EHF and KLF5\n", + "looking for paths in the network with length: 3 for node EHF and KLF5\n", + "looking for paths in the network with length: 4 for node EHF and KLF5\n", + "looking for paths in the network with length: 5 for node EHF and KLF5\n", + "looking for paths in the network with length: 6 for node EHF and KLF5\n", + "i_search = 3\n", + "Looking for paths with length: 0 for node EHF and KLF5\n", + "i_search = 3\n", + "Looking for paths with length: 1 for node EHF and KLF5\n", + "i_search = 3\n", + "Looking for paths with length: 2 for node EHF and KLF5\n", + "i_search = 3\n", + "Looking for paths with length: 3 for node EHF and KLF5\n", + "looking for paths in the network with length: 0 for node EHF and HOXA9\n", + "looking for paths in the network with length: 1 for node EHF and HOXA9\n", + "looking for paths in the network with length: 2 for node EHF and HOXA9\n", + "looking for paths in the network with length: 3 for node EHF and HOXA9\n", + "looking for paths in the network with length: 4 for node EHF and HOXA9\n", + "looking for paths in the network with length: 5 for node EHF and HOXA9\n", + "looking for paths in the network with length: 6 for node EHF and HOXA9\n", + "i_search = 3\n", + "Looking for paths with length: 0 for node EHF and HOXA9\n", + "i_search = 3\n", + "Looking for paths with length: 1 for node EHF and HOXA9\n", + "i_search = 3\n", + "Looking for paths with length: 2 for node EHF and HOXA9\n", + "i_search = 3\n", + "Looking for paths with length: 3 for node EHF and HOXA9\n", + "looking for paths in the network with length: 0 for node EHF and HOXA10\n", + "looking for paths in the network with length: 1 for node EHF and HOXA10\n", + "looking for paths in the network with length: 2 for node EHF and HOXA10\n", + "looking for paths in the network with length: 3 for node EHF and HOXA10\n", + "looking for paths in the network with length: 4 for node EHF and HOXA10\n", + "looking for paths in the network with length: 5 for node EHF and HOXA10\n", + "looking for paths in the network with length: 6 for node EHF and HOXA10\n", + "i_search = 3\n", + "Looking for paths with length: 0 for node EHF and HOXA10\n", + "i_search = 3\n", + "Looking for paths with length: 1 for node EHF and HOXA10\n", + "i_search = 3\n", + "Looking for paths with length: 2 for node EHF and HOXA10\n", + "i_search = 3\n", + "Looking for paths with length: 3 for node EHF and HOXA10\n", + "looking for paths in the network with length: 0 for node EHF and ETV4\n", + "looking for paths in the network with length: 1 for node EHF and ETV4\n", + "looking for paths in the network with length: 2 for node EHF and ETV4\n", + "looking for paths in the network with length: 3 for node EHF and ETV4\n", + "looking for paths in the network with length: 4 for node EHF and ETV4\n", + "looking for paths in the network with length: 5 for node EHF and ETV4\n", + "looking for paths in the network with length: 6 for node EHF and ETV4\n", + "i_search = 3\n", + "Looking for paths with length: 0 for node EHF and ETV4\n", + "i_search = 3\n", + "Looking for paths with length: 1 for node EHF and ETV4\n", + "i_search = 3\n", + "Looking for paths with length: 2 for node EHF and ETV4\n", + "i_search = 3\n", + "Looking for paths with length: 3 for node EHF and ETV4\n", + "looking for paths in the network with length: 0 for node EHF and ETV5\n", + "looking for paths in the network with length: 1 for node EHF and ETV5\n", + "looking for paths in the network with length: 2 for node EHF and ETV5\n", + "looking for paths in the network with length: 3 for node EHF and ETV5\n", + "looking for paths in the network with length: 4 for node EHF and ETV5\n", + "looking for paths in the network with length: 5 for node EHF and ETV5\n", + "looking for paths in the network with length: 6 for node EHF and ETV5\n", + "i_search = 3\n", + "Looking for paths with length: 0 for node EHF and ETV5\n", + "i_search = 3\n", + "Looking for paths with length: 1 for node EHF and ETV5\n", + "i_search = 3\n", + "Looking for paths with length: 2 for node EHF and ETV5\n", + "i_search = 3\n", + "Looking for paths with length: 3 for node EHF and ETV5\n", + "looking for paths in the network with length: 0 for node EHF and POU3F1\n", + "looking for paths in the network with length: 1 for node EHF and POU3F1\n", + "looking for paths in the network with length: 2 for node EHF and POU3F1\n", + "looking for paths in the network with length: 3 for node EHF and POU3F1\n", + "looking for paths in the network with length: 4 for node EHF and POU3F1\n", + "looking for paths in the network with length: 5 for node EHF and POU3F1\n", + "looking for paths in the network with length: 6 for node EHF and POU3F1\n", + "i_search = 3\n", + "Looking for paths with length: 0 for node EHF and POU3F1\n", + "i_search = 3\n", + "Looking for paths with length: 1 for node EHF and POU3F1\n", + "i_search = 3\n", + "Looking for paths with length: 2 for node EHF and POU3F1\n", + "i_search = 3\n", + "Looking for paths with length: 3 for node EHF and POU3F1\n", + "looking for paths in the network with length: 0 for node EHF and CEBPB\n", + "looking for paths in the network with length: 1 for node EHF and CEBPB\n", + "looking for paths in the network with length: 2 for node EHF and CEBPB\n", + "looking for paths in the network with length: 3 for node EHF and CEBPB\n", + "looking for paths in the network with length: 4 for node EHF and CEBPB\n", + "looking for paths in the network with length: 5 for node EHF and CEBPB\n", + "looking for paths in the network with length: 6 for node EHF and CEBPB\n", + "i_search = 3\n", + "Looking for paths with length: 0 for node EHF and CEBPB\n", + "i_search = 3\n", + "Looking for paths with length: 1 for node EHF and CEBPB\n", + "i_search = 3\n", + "Looking for paths with length: 2 for node EHF and CEBPB\n", + "i_search = 3\n", + "Looking for paths with length: 3 for node EHF and CEBPB\n", + "looking for paths in the network with length: 0 for node KLF5 and HOXA9\n", + "looking for paths in the network with length: 1 for node KLF5 and HOXA9\n", + "looking for paths in the network with length: 2 for node KLF5 and HOXA9\n", + "looking for paths in the network with length: 3 for node KLF5 and HOXA9\n", + "looking for paths in the network with length: 4 for node KLF5 and HOXA9\n", + "looking for paths in the network with length: 5 for node KLF5 and HOXA9\n", + "looking for paths in the network with length: 6 for node KLF5 and HOXA9\n", + "i_search = 3\n", + "Looking for paths with length: 0 for node KLF5 and HOXA9\n", + "i_search = 3\n", + "Looking for paths with length: 1 for node KLF5 and HOXA9\n", + "i_search = 3\n", + "Looking for paths with length: 2 for node KLF5 and HOXA9\n", + "i_search = 3\n", + "Looking for paths with length: 3 for node KLF5 and HOXA9\n", + "looking for paths in the network with length: 0 for node KLF5 and HOXA10\n", + "looking for paths in the network with length: 1 for node KLF5 and HOXA10\n", + "looking for paths in the network with length: 2 for node KLF5 and HOXA10\n", + "looking for paths in the network with length: 3 for node KLF5 and HOXA10\n", + "looking for paths in the network with length: 4 for node KLF5 and HOXA10\n", + "looking for paths in the network with length: 5 for node KLF5 and HOXA10\n", + "looking for paths in the network with length: 6 for node KLF5 and HOXA10\n", + "i_search = 3\n", + "Looking for paths with length: 0 for node KLF5 and HOXA10\n", + "i_search = 3\n", + "Looking for paths with length: 1 for node KLF5 and HOXA10\n", + "i_search = 3\n", + "Looking for paths with length: 2 for node KLF5 and HOXA10\n", + "i_search = 3\n", + "Looking for paths with length: 3 for node KLF5 and HOXA10\n", + "looking for paths in the network with length: 0 for node KLF5 and ETV4\n", + "looking for paths in the network with length: 1 for node KLF5 and ETV4\n", + "looking for paths in the network with length: 2 for node KLF5 and ETV4\n", + "looking for paths in the network with length: 3 for node KLF5 and ETV4\n", + "looking for paths in the network with length: 4 for node KLF5 and ETV4\n", + "looking for paths in the network with length: 5 for node KLF5 and ETV4\n", + "looking for paths in the network with length: 6 for node KLF5 and ETV4\n", + "i_search = 3\n", + "Looking for paths with length: 0 for node KLF5 and ETV4\n", + "i_search = 3\n", + "Looking for paths with length: 1 for node KLF5 and ETV4\n", + "i_search = 3\n", + "Looking for paths with length: 2 for node KLF5 and ETV4\n", + "i_search = 3\n", + "Looking for paths with length: 3 for node KLF5 and ETV4\n", + "looking for paths in the network with length: 0 for node KLF5 and ETV5\n", + "looking for paths in the network with length: 1 for node KLF5 and ETV5\n", + "looking for paths in the network with length: 2 for node KLF5 and ETV5\n", + "looking for paths in the network with length: 3 for node KLF5 and ETV5\n", + "looking for paths in the network with length: 4 for node KLF5 and ETV5\n", + "looking for paths in the network with length: 5 for node KLF5 and ETV5\n", + "looking for paths in the network with length: 6 for node KLF5 and ETV5\n", + "i_search = 3\n", + "Looking for paths with length: 0 for node KLF5 and ETV5\n", + "i_search = 3\n", + "Looking for paths with length: 1 for node KLF5 and ETV5\n", + "i_search = 3\n", + "Looking for paths with length: 2 for node KLF5 and ETV5\n", + "i_search = 3\n", + "Looking for paths with length: 3 for node KLF5 and ETV5\n", + "looking for paths in the network with length: 0 for node KLF5 and POU3F1\n", + "looking for paths in the network with length: 1 for node KLF5 and POU3F1\n", + "looking for paths in the network with length: 2 for node KLF5 and POU3F1\n", + "looking for paths in the network with length: 3 for node KLF5 and POU3F1\n", + "looking for paths in the network with length: 4 for node KLF5 and POU3F1\n", + "looking for paths in the network with length: 5 for node KLF5 and POU3F1\n", + "looking for paths in the network with length: 6 for node KLF5 and POU3F1\n", + "i_search = 3\n", + "Looking for paths with length: 0 for node KLF5 and POU3F1\n", + "i_search = 3\n", + "Looking for paths with length: 1 for node KLF5 and POU3F1\n", + "i_search = 3\n", + "Looking for paths with length: 2 for node KLF5 and POU3F1\n", + "i_search = 3\n", + "Looking for paths with length: 3 for node KLF5 and POU3F1\n", + "looking for paths in the network with length: 0 for node KLF5 and CEBPB\n", + "looking for paths in the network with length: 1 for node KLF5 and CEBPB\n", + "Found a path!\n", + "[['KLF5', 'CEBPB']]\n", + "looking for paths in the network with length: 0 for node HOXA9 and HOXA10\n", + "looking for paths in the network with length: 1 for node HOXA9 and HOXA10\n", + "looking for paths in the network with length: 2 for node HOXA9 and HOXA10\n", + "looking for paths in the network with length: 3 for node HOXA9 and HOXA10\n", + "looking for paths in the network with length: 4 for node HOXA9 and HOXA10\n", + "looking for paths in the network with length: 5 for node HOXA9 and HOXA10\n", + "looking for paths in the network with length: 6 for node HOXA9 and HOXA10\n", + "i_search = 3\n", + "Looking for paths with length: 0 for node HOXA9 and HOXA10\n", + "i_search = 3\n", + "Looking for paths with length: 1 for node HOXA9 and HOXA10\n", + "i_search = 3\n", + "Looking for paths with length: 2 for node HOXA9 and HOXA10\n", + "i_search = 3\n", + "Looking for paths with length: 3 for node HOXA9 and HOXA10\n", + "looking for paths in the network with length: 0 for node HOXA9 and ETV4\n", + "looking for paths in the network with length: 1 for node HOXA9 and ETV4\n", + "looking for paths in the network with length: 2 for node HOXA9 and ETV4\n", + "looking for paths in the network with length: 3 for node HOXA9 and ETV4\n", + "looking for paths in the network with length: 4 for node HOXA9 and ETV4\n", + "looking for paths in the network with length: 5 for node HOXA9 and ETV4\n", + "looking for paths in the network with length: 6 for node HOXA9 and ETV4\n", + "i_search = 3\n", + "Looking for paths with length: 0 for node HOXA9 and ETV4\n", + "i_search = 3\n", + "Looking for paths with length: 1 for node HOXA9 and ETV4\n", + "i_search = 3\n", + "Looking for paths with length: 2 for node HOXA9 and ETV4\n", + "i_search = 3\n", + "Looking for paths with length: 3 for node HOXA9 and ETV4\n", + "looking for paths in the network with length: 0 for node HOXA9 and ETV5\n", + "looking for paths in the network with length: 1 for node HOXA9 and ETV5\n", + "looking for paths in the network with length: 2 for node HOXA9 and ETV5\n", + "looking for paths in the network with length: 3 for node HOXA9 and ETV5\n", + "looking for paths in the network with length: 4 for node HOXA9 and ETV5\n", + "looking for paths in the network with length: 5 for node HOXA9 and ETV5\n", + "looking for paths in the network with length: 6 for node HOXA9 and ETV5\n", + "i_search = 3\n", + "Looking for paths with length: 0 for node HOXA9 and ETV5\n", + "i_search = 3\n", + "Looking for paths with length: 1 for node HOXA9 and ETV5\n", + "i_search = 3\n", + "Looking for paths with length: 2 for node HOXA9 and ETV5\n", + "i_search = 3\n", + "Looking for paths with length: 3 for node HOXA9 and ETV5\n", + "looking for paths in the network with length: 0 for node HOXA9 and POU3F1\n", + "looking for paths in the network with length: 1 for node HOXA9 and POU3F1\n", + "looking for paths in the network with length: 2 for node HOXA9 and POU3F1\n", + "looking for paths in the network with length: 3 for node HOXA9 and POU3F1\n", + "looking for paths in the network with length: 4 for node HOXA9 and POU3F1\n", + "looking for paths in the network with length: 5 for node HOXA9 and POU3F1\n", + "looking for paths in the network with length: 6 for node HOXA9 and POU3F1\n", + "i_search = 3\n", + "Looking for paths with length: 0 for node HOXA9 and POU3F1\n", + "i_search = 3\n", + "Looking for paths with length: 1 for node HOXA9 and POU3F1\n", + "i_search = 3\n", + "Looking for paths with length: 2 for node HOXA9 and POU3F1\n", + "i_search = 3\n", + "Looking for paths with length: 3 for node HOXA9 and POU3F1\n", + "looking for paths in the network with length: 0 for node HOXA9 and CEBPB\n", + "looking for paths in the network with length: 1 for node HOXA9 and CEBPB\n", + "looking for paths in the network with length: 2 for node HOXA9 and CEBPB\n", + "looking for paths in the network with length: 3 for node HOXA9 and CEBPB\n", + "looking for paths in the network with length: 4 for node HOXA9 and CEBPB\n", + "looking for paths in the network with length: 5 for node HOXA9 and CEBPB\n", + "looking for paths in the network with length: 6 for node HOXA9 and CEBPB\n", + "i_search = 3\n", + "Looking for paths with length: 0 for node HOXA9 and CEBPB\n", + "i_search = 3\n", + "Looking for paths with length: 1 for node HOXA9 and CEBPB\n", + "i_search = 3\n", + "Looking for paths with length: 2 for node HOXA9 and CEBPB\n", + "i_search = 3\n", + "Looking for paths with length: 3 for node HOXA9 and CEBPB\n", + "[['HOXA9', 'PIM1', 'FLT3', 'CEBPB']]\n", + "P31269 P11309\n", + "P11309 P36888\n", + "P36888 P17676\n", + "P55317 P0DMV8\n", + "P55317 P10275\n", + "P55317 O00712\n", + "P17676 Q13887\n", + "P04150 Q13887\n", + "Q15910 P31269\n", + "P31269 P11309\n", + "Q15910 P31260\n", + "O00712 P41161\n", + "P04150 P17676\n", + "P36888 P17676\n", + "P0DMV8 P04150\n", + "P04150 P10275\n", + "P10275 P04150\n", + "Q15910 P10275\n", + "O00712 Q15910\n", + "P11309 P36888\n", + "P36888 P11309\n", + "looking for paths in the network with length: 0 for node HOXA10 and ETV4\n", + "looking for paths in the network with length: 1 for node HOXA10 and ETV4\n", + "looking for paths in the network with length: 2 for node HOXA10 and ETV4\n", + "looking for paths in the network with length: 3 for node HOXA10 and ETV4\n", + "looking for paths in the network with length: 4 for node HOXA10 and ETV4\n", + "looking for paths in the network with length: 5 for node HOXA10 and ETV4\n", + "looking for paths in the network with length: 6 for node HOXA10 and ETV4\n", + "i_search = 3\n", + "Looking for paths with length: 0 for node HOXA10 and ETV4\n", + "i_search = 3\n", + "Looking for paths with length: 1 for node HOXA10 and ETV4\n", + "i_search = 3\n", + "Looking for paths with length: 2 for node HOXA10 and ETV4\n", + "i_search = 3\n", + "Looking for paths with length: 3 for node HOXA10 and ETV4\n", + "looking for paths in the network with length: 0 for node HOXA10 and ETV5\n", + "looking for paths in the network with length: 1 for node HOXA10 and ETV5\n", + "looking for paths in the network with length: 2 for node HOXA10 and ETV5\n", + "looking for paths in the network with length: 3 for node HOXA10 and ETV5\n", + "looking for paths in the network with length: 4 for node HOXA10 and ETV5\n", + "looking for paths in the network with length: 5 for node HOXA10 and ETV5\n", + "looking for paths in the network with length: 6 for node HOXA10 and ETV5\n", + "i_search = 3\n", + "Looking for paths with length: 0 for node HOXA10 and ETV5\n", + "i_search = 3\n", + "Looking for paths with length: 1 for node HOXA10 and ETV5\n", + "i_search = 3\n", + "Looking for paths with length: 2 for node HOXA10 and ETV5\n", + "i_search = 3\n", + "Looking for paths with length: 3 for node HOXA10 and ETV5\n", + "looking for paths in the network with length: 0 for node HOXA10 and POU3F1\n", + "looking for paths in the network with length: 1 for node HOXA10 and POU3F1\n", + "looking for paths in the network with length: 2 for node HOXA10 and POU3F1\n", + "looking for paths in the network with length: 3 for node HOXA10 and POU3F1\n", + "looking for paths in the network with length: 4 for node HOXA10 and POU3F1\n", + "looking for paths in the network with length: 5 for node HOXA10 and POU3F1\n", + "looking for paths in the network with length: 6 for node HOXA10 and POU3F1\n", + "i_search = 3\n", + "Looking for paths with length: 0 for node HOXA10 and POU3F1\n", + "i_search = 3\n", + "Looking for paths with length: 1 for node HOXA10 and POU3F1\n", + "i_search = 3\n", + "Looking for paths with length: 2 for node HOXA10 and POU3F1\n", + "i_search = 3\n", + "Looking for paths with length: 3 for node HOXA10 and POU3F1\n", + "looking for paths in the network with length: 0 for node HOXA10 and CEBPB\n", + "looking for paths in the network with length: 1 for node HOXA10 and CEBPB\n", + "looking for paths in the network with length: 2 for node HOXA10 and CEBPB\n", + "looking for paths in the network with length: 3 for node HOXA10 and CEBPB\n", + "looking for paths in the network with length: 4 for node HOXA10 and CEBPB\n", + "looking for paths in the network with length: 5 for node HOXA10 and CEBPB\n", + "looking for paths in the network with length: 6 for node HOXA10 and CEBPB\n", + "i_search = 3\n", + "Looking for paths with length: 0 for node HOXA10 and CEBPB\n", + "i_search = 3\n", + "Looking for paths with length: 1 for node HOXA10 and CEBPB\n", + "i_search = 3\n", + "Looking for paths with length: 2 for node HOXA10 and CEBPB\n", + "i_search = 3\n", + "Looking for paths with length: 3 for node HOXA10 and CEBPB\n", + "looking for paths in the network with length: 0 for node ETV4 and ETV5\n", + "looking for paths in the network with length: 1 for node ETV4 and ETV5\n", + "looking for paths in the network with length: 2 for node ETV4 and ETV5\n", + "looking for paths in the network with length: 3 for node ETV4 and ETV5\n", + "looking for paths in the network with length: 4 for node ETV4 and ETV5\n", + "looking for paths in the network with length: 5 for node ETV4 and ETV5\n", + "looking for paths in the network with length: 6 for node ETV4 and ETV5\n", + "i_search = 3\n", + "Looking for paths with length: 0 for node ETV4 and ETV5\n", + "i_search = 3\n", + "Looking for paths with length: 1 for node ETV4 and ETV5\n", + "i_search = 3\n", + "Looking for paths with length: 2 for node ETV4 and ETV5\n", + "i_search = 3\n", + "Looking for paths with length: 3 for node ETV4 and ETV5\n", + "looking for paths in the network with length: 0 for node ETV4 and POU3F1\n", + "looking for paths in the network with length: 1 for node ETV4 and POU3F1\n", + "looking for paths in the network with length: 2 for node ETV4 and POU3F1\n", + "looking for paths in the network with length: 3 for node ETV4 and POU3F1\n", + "looking for paths in the network with length: 4 for node ETV4 and POU3F1\n", + "looking for paths in the network with length: 5 for node ETV4 and POU3F1\n", + "looking for paths in the network with length: 6 for node ETV4 and POU3F1\n", + "i_search = 3\n", + "Looking for paths with length: 0 for node ETV4 and POU3F1\n", + "i_search = 3\n", + "Looking for paths with length: 1 for node ETV4 and POU3F1\n", + "i_search = 3\n", + "Looking for paths with length: 2 for node ETV4 and POU3F1\n", + "i_search = 3\n", + "Looking for paths with length: 3 for node ETV4 and POU3F1\n", + "looking for paths in the network with length: 0 for node ETV4 and CEBPB\n", + "looking for paths in the network with length: 1 for node ETV4 and CEBPB\n", + "looking for paths in the network with length: 2 for node ETV4 and CEBPB\n", + "looking for paths in the network with length: 3 for node ETV4 and CEBPB\n", + "looking for paths in the network with length: 4 for node ETV4 and CEBPB\n", + "looking for paths in the network with length: 5 for node ETV4 and CEBPB\n", + "looking for paths in the network with length: 6 for node ETV4 and CEBPB\n", + "i_search = 3\n", + "Looking for paths with length: 0 for node ETV4 and CEBPB\n", + "i_search = 3\n", + "Looking for paths with length: 1 for node ETV4 and CEBPB\n", + "i_search = 3\n", + "Looking for paths with length: 2 for node ETV4 and CEBPB\n", + "i_search = 3\n", + "Looking for paths with length: 3 for node ETV4 and CEBPB\n", + "looking for paths in the network with length: 0 for node ETV5 and POU3F1\n", + "looking for paths in the network with length: 1 for node ETV5 and POU3F1\n", + "looking for paths in the network with length: 2 for node ETV5 and POU3F1\n", + "looking for paths in the network with length: 3 for node ETV5 and POU3F1\n", + "looking for paths in the network with length: 4 for node ETV5 and POU3F1\n", + "looking for paths in the network with length: 5 for node ETV5 and POU3F1\n", + "looking for paths in the network with length: 6 for node ETV5 and POU3F1\n", + "i_search = 3\n", + "Looking for paths with length: 0 for node ETV5 and POU3F1\n", + "i_search = 3\n", + "Looking for paths with length: 1 for node ETV5 and POU3F1\n", + "i_search = 3\n", + "Looking for paths with length: 2 for node ETV5 and POU3F1\n", + "i_search = 3\n", + "Looking for paths with length: 3 for node ETV5 and POU3F1\n", + "looking for paths in the network with length: 0 for node ETV5 and CEBPB\n", + "looking for paths in the network with length: 1 for node ETV5 and CEBPB\n", + "looking for paths in the network with length: 2 for node ETV5 and CEBPB\n", + "looking for paths in the network with length: 3 for node ETV5 and CEBPB\n", + "looking for paths in the network with length: 4 for node ETV5 and CEBPB\n", + "looking for paths in the network with length: 5 for node ETV5 and CEBPB\n", + "looking for paths in the network with length: 6 for node ETV5 and CEBPB\n", + "i_search = 3\n", + "Looking for paths with length: 0 for node ETV5 and CEBPB\n", + "i_search = 3\n", + "Looking for paths with length: 1 for node ETV5 and CEBPB\n", + "i_search = 3\n", + "Looking for paths with length: 2 for node ETV5 and CEBPB\n", + "i_search = 3\n", + "Looking for paths with length: 3 for node ETV5 and CEBPB\n", + "looking for paths in the network with length: 0 for node POU3F1 and CEBPB\n", + "looking for paths in the network with length: 1 for node POU3F1 and CEBPB\n", + "looking for paths in the network with length: 2 for node POU3F1 and CEBPB\n", + "looking for paths in the network with length: 3 for node POU3F1 and CEBPB\n", + "looking for paths in the network with length: 4 for node POU3F1 and CEBPB\n", + "looking for paths in the network with length: 5 for node POU3F1 and CEBPB\n", + "looking for paths in the network with length: 6 for node POU3F1 and CEBPB\n", + "i_search = 3\n", + "Looking for paths with length: 0 for node POU3F1 and CEBPB\n", + "i_search = 3\n", + "Looking for paths with length: 1 for node POU3F1 and CEBPB\n", + "i_search = 3\n", + "Looking for paths with length: 2 for node POU3F1 and CEBPB\n", + "i_search = 3\n", + "Looking for paths with length: 3 for node POU3F1 and CEBPB\n", + "CPU times: user 8.91 s, sys: 36 ms, total: 8.95 s\n", + "Wall time: 8.91 s\n" + ] + } + ], + "source": [ + "%%time\n", + "new_net1.complete_connection(mode=\"ALL\", maxlen=6, k_mean=\"tight\", only_signed=True,\n", + " connect_node_when_first_introduced=True) # here, consensus_only is missing, in this way it is automatically False" + ] + }, + { + "cell_type": "markdown", + "id": "64b445e7-2e45-40ee-9ee9-268965b4d55b", + "metadata": {}, + "source": [ + "## SIGNOR uses has different identifiers for complexes, protein family, phenotype, etc.\n", + "## It is possible that the network contains nodes names like \"Signor_pf32\" or something like this... This is not yet translated, but if you are interested in what those nodes consist of, you can use download their vocabulary for the entities: https://signor.uniroma2.it/downloads.php\n", + "## Maybe we are going to integrate this too... " + ] + }, + { + "cell_type": "markdown", + "id": "6b54c437", + "metadata": {}, + "source": [ + "### Finally we can export the network in bnet format with some basic logical equations or in sif format for Cytoscape visualization" + ] + }, + { + "cell_type": "code", + "execution_count": 13, + "id": "547e4090", + "metadata": {}, + "outputs": [], + "source": [ + "from omniflow_project._outputs.exports import Exports" + ] + }, + { + "cell_type": "code", + "execution_count": 14, + "id": "6fd81835", + "metadata": {}, + "outputs": [], + "source": [ + "export = Exports(new_net1)" + ] + }, + { + "cell_type": "code", + "execution_count": 15, + "id": "a408094f", + "metadata": {}, + "outputs": [], + "source": [ + "export.export_bnet()\n", + "export.export_sif()" + ] + }, + { + "cell_type": "markdown", + "id": "8ed135d3-9f71-4cec-9381-96c63fba766e", + "metadata": {}, + "source": [ + "### Gene Ontology\n", + "## A new feature of Omniflow. Now, the user can connect the nodes of the Network with markers of a certain phenotype, from Gene Ontology. " + ] + }, + { + "cell_type": "code", + "execution_count": 10, + "id": "fa499a38-c22a-4a0e-b1d4-3ffb10e4a370", + "metadata": {}, + "outputs": [ + { + "name": "stdout", + "output_type": "stream", + "text": [ + "Start requesting genes from Gene Ontology\n", + "Fetching from: https://golr-aux.geneontology.io/solr/select?defType=edismax&qt=standard&indent=on&wt=csv&rows=100000&start=0&fl=bioentity_label&facet=true&facet.mincount=1&facet.sort=count&json.nl=arrarr&facet.limit=25&hl=true&hl.simple.pre=%3Cem%20class=%22hilite%22%3E&hl.snippets=1000&csv.encapsulator=&csv.separator=%09&csv.header=false&csv.mv.separator=%7C&fq=document_category:%22annotation%22&fq=isa_partof_closure:%22GO:0097194%22&fq=taxon_subset_closure_label:%22Homo%20sapiens%22&fq=type:%22protein%22&fq=annotation_class_label:%22execution%20phase%20of%20apoptosis%22&facet.field=aspect&facet.field=taxon_subset_closure_label&facet.field=type&facet.field=evidence_subset_closure_label&facet.field=regulates_closure_label&facet.field=isa_partof_closure_label&facet.field=annotation_class_label&facet.field=qualifier&facet.field=annotation_extension_class_closure_label&facet.field=assigned_by&facet.field=panther_family_label&q=*:*\n", + "Done\n", + "Starting connecting network's nodes to: ['AIFM3', 'CASP7', 'MADD', 'CASP3', 'CASP8', 'CASP5', 'BNIP1', 'CIDEC', 'COLEC11', 'HTRA2', 'CASP12', 'TAOK1', 'BBC3', 'CFLAR', 'CIDEB', 'NFKBIZ', 'CASP6', 'STK24', 'CASP4', 'AKT1', 'NPR2', 'CASP2', 'CECR2']\n", + "Q01094 Q96PG8\n", + "P28482 Q14790\n", + "P31749 O15519\n", + "P31749 O43464\n", + "P06493 Q14790\n", + "P62136 P42575\n", + "SIGNOR-PF54 P42575\n", + "Q13315 Q7L7X3\n", + "P68400 P42575\n", + "Q16539 O15519\n", + "Q16539 P42574\n", + "Q16539 Q14790\n", + "P27361 Q14790\n", + "SIGNOR-PF1 Q14790\n", + "CPU times: user 1.17 s, sys: 1.02 ms, total: 1.17 s\n", + "Wall time: 1.98 s\n" + ] + } + ], + "source": [ + "%%time\n", + "new_net1.connect_genes_to_phenotype(id_accession=\"GO:0097194\", phenotype=\"execution phase of apoptosis\", only_signed=True, compress=True, maxlen=1)" + ] + }, + { + "cell_type": "markdown", + "id": "48bf53a4", + "metadata": {}, + "source": [ + "# TO DO:\n", + "\n", + "- method to print sif file with reference for each interaction (easy task)\n", + "- more utility functions (???)\n", + "- create function to look for common upstream for group of nodes" + ] + }, + { + "cell_type": "code", + "execution_count": null, + "id": "33300268-bcf6-442b-97be-c7718922a939", + "metadata": {}, + "outputs": [], + "source": [] + } + ], + "metadata": { + "kernelspec": { + "display_name": "Python 3 (ipykernel)", + "language": "python", + "name": "python3" + }, + "language_info": { + "codemirror_mode": { + "name": "ipython", + "version": 3 + }, + "file_extension": ".py", + "mimetype": "text/x-python", + "name": "python", + "nbconvert_exporter": "python", + "pygments_lexer": "ipython3", + "version": "3.10.13" + } + }, + "nbformat": 4, + "nbformat_minor": 5 +} diff --git a/notebooks/.ipynb_checkpoints/ontology-checkpoint.ipynb b/notebooks/.ipynb_checkpoints/ontology-checkpoint.ipynb new file mode 100644 index 0000000..0865f88 --- /dev/null +++ b/notebooks/.ipynb_checkpoints/ontology-checkpoint.ipynb @@ -0,0 +1,9451 @@ +{ + "cells": [ + { + "cell_type": "markdown", + "id": "55b5595c-fec9-41c3-b756-b95cd0c52048", + "metadata": {}, + "source": [ + "## Add resources\n", + "\n", + "This notebook explores how you can explore whether the nodes in your network are expressed in a tissue of interest. The annotations are accessed from the Annotation object of Omnipath, and are based on expression data from the Human Protein Atlas." + ] + }, + { + "cell_type": "code", + "execution_count": 2, + "id": "3c317de8", + "metadata": {}, + "outputs": [ + { + "name": "stderr", + "output_type": "stream", + "text": [ + "/home/eirini/anaconda3/envs/omniflow_env/lib/python3.10/site-packages/tqdm/auto.py:21: TqdmWarning: IProgress not found. Please update jupyter and ipywidgets. See https://ipywidgets.readthedocs.io/en/stable/user_install.html\n", + " from .autonotebook import tqdm as notebook_tqdm\n" + ] + }, + { + "ename": "ModuleNotFoundError", + "evalue": "No module named 'omniflow_project._annotations'", + "output_type": "error", + "traceback": [ + "\u001b[0;31m---------------------------------------------------------------------------\u001b[0m", + "\u001b[0;31mModuleNotFoundError\u001b[0m Traceback (most recent call last)", + "File \u001b[0;32m:4\u001b[0m\n", + "\u001b[0;31mModuleNotFoundError\u001b[0m: No module named 'omniflow_project._annotations'" + ] + } + ], + "source": [ + "%%time\n", + "from omniflow_project.core.network import Network\n", + "from omniflow_project._visual.visualize_network import NetworkVisualizer\n", + "from omniflow_project._inputs.resources import Resources\n", + "from omniflow_project._annotations.gene_ontology import Ontology\n", + "import omnipath as op" + ] + }, + { + "cell_type": "markdown", + "id": "2910c871-fdfc-4d20-b76f-af213f06a3f0", + "metadata": {}, + "source": [ + "### 1. Import genes as network nodes" + ] + }, + { + "cell_type": "code", + "execution_count": 3, + "id": "79c09e13", + "metadata": {}, + "outputs": [], + "source": [ + "genes = [\"SRC\", \"NOTCH1\", \"FAK\", \"CDH1\", \"CDH2\", \"VIM\", \"MAP4K4\", \"LATS1\", \"LATS2\", \"PTK2B\"]" + ] + }, + { + "cell_type": "code", + "execution_count": 3, + "id": "fcf68a99-8454-41e3-8816-c3f976d04c0b", + "metadata": {}, + "outputs": [ + { + "name": "stdout", + "output_type": "stream", + "text": [ + "Loading deafault omnipath all interactions\n" + ] + } + ], + "source": [ + "new_net1 = Network(genes)" + ] + }, + { + "cell_type": "code", + "execution_count": 4, + "id": "fad00bec-ba72-4943-bf1e-9c60f58f17a2", + "metadata": {}, + "outputs": [ + { + "ename": "NameError", + "evalue": "name 'new_net1' is not defined", + "output_type": "error", + "traceback": [ + "\u001b[0;31m---------------------------------------------------------------------------\u001b[0m", + "\u001b[0;31mNameError\u001b[0m Traceback (most recent call last)", + "Cell \u001b[0;32mIn[4], line 2\u001b[0m\n\u001b[1;32m 1\u001b[0m \u001b[38;5;66;03m#Print node dataframe\u001b[39;00m\n\u001b[0;32m----> 2\u001b[0m \u001b[43mnew_net1\u001b[49m\u001b[38;5;241m.\u001b[39mnodes\n", + "\u001b[0;31mNameError\u001b[0m: name 'new_net1' is not defined" + ] + } + ], + "source": [ + "#Print node dataframe\n", + "new_net1.nodes" + ] + }, + { + "cell_type": "markdown", + "id": "3e9006ec-00d2-453d-8b8f-e939938e9068", + "metadata": {}, + "source": [ + "### 2. Check if the genes are annotated in the tissue of interest (e.g., in colorectal cancer)" + ] + }, + { + "cell_type": "code", + "execution_count": 13, + "id": "9540f33d-68f8-4c98-b68e-3e3d1497467e", + "metadata": {}, + "outputs": [ + { + "name": "stdout", + "output_type": "stream", + "text": [ + " Genesymbol in_tissue\n", + "0 SRC True\n", + "1 NOTCH1 True\n", + "2 PTK2 True\n", + "3 CDH1 True\n", + "4 CDH2 True\n", + "5 VIM True\n", + "6 MAP4K4 True\n", + "7 LATS1 True\n", + "8 LATS2 True\n", + "9 PTK2B True\n", + "10 CTNNB1 True\n", + "11 DAB1 True\n", + "12 MET True\n", + "13 PRKD1 True\n", + "14 CTNND1 True\n", + "15 PAK2 True\n", + "16 MAPK8 True\n", + "17 MAP3K7 True\n", + "18 MAP3K1 True\n", + "19 RAF1 True\n", + "20 STK3 True\n", + "21 STK4 True\n", + "22 NF2 True\n", + "23 SMAD3 True\n", + "24 BCAR1 True\n", + "25 LCK True\n", + "26 PTPRH True\n", + "27 WWTR1 True\n", + "28 YAP1 True\n", + "29 RUNX2 True\n", + "30 EGFR True\n" + ] + } + ], + "source": [ + "annot = Ontology()\n", + "results_df = annot.check_tissue_annotations(genes_df = new_net1.nodes, tissue = 'colorectal cancer')\n", + "print(results_df)" + ] + }, + { + "cell_type": "markdown", + "id": "6a05e120-424b-405f-be04-f8c3725f950b", + "metadata": {}, + "source": [ + "### 3. Color nodes based on their presence/absence in the tissue of interest" + ] + }, + { + "cell_type": "code", + "execution_count": 12, + "id": "fbd98405-045a-4316-8174-e96e9a71d9ee", + "metadata": {}, + "outputs": [ + { + "data": { + "image/svg+xml": [ + "\n", + "\n", + "\n", + "\n", + "\n", + "\n", + "%3\n", + "\n", + "\n", + "\n", + "SRC\n", + "\n", + "SRC\n", + "\n", + "\n", + "\n", + "PTK2\n", + "\n", + "PTK2\n", + "\n", + "\n", + "\n", + "SRC->PTK2\n", + "\n", + "\n", + "\n", + "\n", + "\n", + "CDH2\n", + "\n", + "CDH2\n", + "\n", + "\n", + "\n", + "SRC->CDH2\n", + "\n", + "\n", + "\n", + "\n", + "\n", + "\n", + "PTK2B\n", + "\n", + "PTK2B\n", + "\n", + "\n", + "\n", + "SRC->PTK2B\n", + "\n", + "\n", + "\n", + "\n", + "\n", + "CTNNB1\n", + "\n", + "CTNNB1\n", + "\n", + "\n", + "\n", + "SRC->CTNNB1\n", + "\n", + "\n", + "\n", + "\n", + "\n", + "DAB1\n", + "\n", + "DAB1\n", + "\n", + "\n", + "\n", + "SRC->DAB1\n", + "\n", + "\n", + "\n", + "\n", + "\n", + "MET\n", + "\n", + "MET\n", + 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"\n", + "\n", + "\n", + "YAP1->CTNNB1\n", + "\n", + "\n", + "\n", + "\n", + "\n", + "YAP1->RUNX2\n", + "\n", + "\n", + "\n", + "\n", + "\n", + "\n", + "RUNX2->NOTCH1\n", + "\n", + "\n", + "\n", + "\n", + "\n", + "\n", + "EGFR->PTK2\n", + "\n", + "\n", + "\n", + "\n", + "\n", + "EGFR->CTNNB1\n", + "\n", + "\n", + "\n", + "\n", + "\n", + "EGFR->CTNND1\n", + "\n", + "\n", + "\n", + "\n", + "\n", + "\n", + "EGFR->BCAR1\n", + "\n", + "\n", + "\n", + "\n", + "\n", + "\n" + ], + "text/plain": [ + "" + ] + }, + "metadata": {}, + "output_type": "display_data" + } + ], + "source": [ + "network_visualizer = NetworkVisualizer(new_net1)\n", + "network_visualizer.tissue_mapping(results_df)\n", + "network_visualizer.render()" + ] + }, + { + "cell_type": "code", + "execution_count": 7, + "id": "db39112a", + "metadata": {}, + "outputs": [ + { + "data": { + "image/svg+xml": [ + "\n", + "\n", + "\n", + "\n", + "\n", + "\n", + "%3\n", + "\n", + "\n", + "\n", + "SRC\n", + "\n", + "SRC\n", + "\n", + "\n", + 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+ "cell_type": "markdown", + "id": "3c1725cc-4c08-4a85-b26c-8f59936e351d", + "metadata": {}, + "source": [ + "#### 4D. Connect disconnected nodes by importing intermediate nodes.\n", + "\n", + "The parameter _*maxlen*_ is used to verify that in the network all the nodes have a distance < than maxlen. \n", + "\n", + "The parameter _*only_signed*_ forces the algorithm to look for just signed interactions. \n", + "\n", + "The parameter _*consensus*_ retrieves those interactions with a sign consensus between the references. \n", + "\n", + "The parameter _*connect_node_when_first_introduced*_, changes the base algorithm, making it look for possible connection between all the disconnected node in the network when a new bridge-gene is introduced in the network." + ] + }, + { + "cell_type": "code", + "execution_count": 8, + "id": "9a07d77b", + "metadata": {}, + "outputs": [ + { + "name": "stdout", + "output_type": "stream", + "text": [ + "looking for paths in the network with length: 0 for node SRC and NOTCH1\n", + "looking for paths in the network with length: 1 for node SRC and NOTCH1\n", + "looking for paths in the network with length: 2 for node SRC and NOTCH1\n", + "looking for paths in the network with length: 3 for node SRC and NOTCH1\n", + "looking for paths in the network with length: 4 for node SRC and NOTCH1\n", + "looking for paths in the network with length: 5 for node SRC and NOTCH1\n", + "looking for paths in the network with length: 6 for node SRC and NOTCH1\n", + "i_search = 3\n", + "Looking for paths with length: 0 for node SRC and NOTCH1\n", + "i_search = 3\n", + "Looking for paths with length: 1 for node SRC and NOTCH1\n", + "i_search = 3\n", + "Looking for paths with length: 2 for node SRC and NOTCH1\n", + "[['SRC', 'CTNNB1', 'NOTCH1'], ['SRC', 'DAB1', 'NOTCH1']]\n", + "P12931 P35222\n", + "P35222 P46531\n", + "P12931 O75553\n", + "O75553 P46531\n", + "P12931 Q05397\n", + "P12931 P19022\n", + "P12931 Q14289\n", + "P12931 P35222\n", + "P12931 O75553\n", + "P35222 P46531\n", + "O75553 P46531\n", + "Q14289 Q05397\n", + "P12830 P35222\n", + "P19022 P35222\n", + "looking for paths in the network with length: 0 for node SRC and PTK2\n", + "looking for paths in the network with length: 1 for node SRC and PTK2\n", + "Found a path!\n", + "[['SRC', 'PTK2']]\n", + "looking for paths in the network with length: 0 for node SRC and CDH1\n", + "looking for paths in the network with length: 1 for node SRC and CDH1\n", + "looking for paths in the network with length: 2 for node SRC and CDH1\n", + "looking for paths in the network with length: 3 for node SRC and CDH1\n", + "looking for paths in the network with length: 4 for node SRC and CDH1\n", + "looking for paths in the network with length: 5 for node SRC and CDH1\n", + "looking for paths in the network with length: 6 for node SRC and CDH1\n", + "i_search = 3\n", + "Looking for paths with length: 0 for node SRC and CDH1\n", + "i_search = 3\n", + "Looking for paths with length: 1 for node SRC and CDH1\n", + "i_search = 3\n", + "Looking for paths with length: 2 for node SRC and CDH1\n", + "[['SRC', 'MET', 'CDH1'], ['SRC', 'PRKD1', 'CDH1'], ['SRC', 'CTNND1', 'CDH1']]\n", + "P12931 P08581\n", + "P08581 P12830\n", + "P12931 Q15139\n", + "Q15139 P12830\n", + "P12931 O60716\n", + "O60716 P12830\n", + "P12931 Q05397\n", + "P12931 P19022\n", + "P12931 Q14289\n", + "P12931 P35222\n", + "P12931 O75553\n", + "P12931 P08581\n", + "P12931 Q15139\n", + "P12931 O60716\n", + "P35222 P46531\n", + "O75553 P46531\n", + "Q14289 Q05397\n", + "P08581 Q05397\n", + "P12830 P35222\n", + "P08581 P12830\n", + "Q15139 P12830\n", + "O60716 P12830\n", + "P19022 P35222\n", + "O60716 P19022\n", + "Q15139 P35222\n", + "looking for paths in the network with length: 0 for node SRC and CDH2\n", + "looking for paths in the network with length: 1 for node SRC and CDH2\n", + "Found a path!\n", + "[['SRC', 'CDH2']]\n", + "looking for paths in the network with length: 0 for node SRC and VIM\n", + "looking for paths in the network with length: 1 for node SRC and VIM\n", + "looking for paths in the network with length: 2 for node SRC and VIM\n", + "looking for paths in the network with length: 3 for node SRC and VIM\n", + "looking for paths in the network with length: 4 for node SRC and VIM\n", + "looking for paths in the network with length: 5 for node SRC and VIM\n", + "looking for paths in the network with length: 6 for node SRC and VIM\n", + "i_search = 3\n", + "Looking for paths with length: 0 for node SRC and VIM\n", + "i_search = 3\n", + "Looking for paths with length: 1 for node SRC and VIM\n", + "i_search = 3\n", + "Looking for paths with length: 2 for node SRC and VIM\n", + "[['SRC', 'PAK2', 'VIM']]\n", + "P12931 Q13177\n", + "Q13177 P08670\n", + "P12931 Q05397\n", + "P12931 P19022\n", + "P12931 Q14289\n", + "P12931 P35222\n", + "P12931 O75553\n", + "P12931 P08581\n", + "P12931 Q15139\n", + "P12931 O60716\n", + "P12931 Q13177\n", + "P35222 P46531\n", + "O75553 P46531\n", + "Q14289 Q05397\n", + "P08581 Q05397\n", + "P12830 P35222\n", + "P08581 P12830\n", + "Q15139 P12830\n", + "O60716 P12830\n", + "P19022 P35222\n", + "O60716 P19022\n", + "Q13177 P08670\n", + "Q15139 P35222\n", + "looking for paths in the network with length: 0 for node SRC and MAP4K4\n", + "looking for paths in the network with length: 1 for node SRC and MAP4K4\n", + "looking for paths in the network with length: 2 for node SRC and MAP4K4\n", + "looking for paths in the network with length: 3 for node SRC and MAP4K4\n", + "looking for paths in the network with length: 4 for node SRC and MAP4K4\n", + "looking for paths in the network with length: 5 for node SRC and MAP4K4\n", + "looking for paths in the network with length: 6 for node SRC and MAP4K4\n", + "i_search = 3\n", + "Looking for paths with length: 0 for node SRC and MAP4K4\n", + "i_search = 3\n", + "Looking for paths with length: 1 for node SRC and MAP4K4\n", + "i_search = 3\n", + "Looking for paths with length: 2 for node SRC and MAP4K4\n", + "i_search = 3\n", + "Looking for paths with length: 3 for node SRC and MAP4K4\n", + "[['SRC', 'MAPK8', 'MAP3K7', 'MAP4K4'], ['SRC', 'MAPK8', 'MAP3K1', 'MAP4K4']]\n", + "P45983 P12931\n", + "O43318 P45983\n", + "O95819 O43318\n", + "P45983 P12931\n", + "Q13233 P45983\n", + "O95819 Q13233\n", + "P12931 Q05397\n", + "P12931 P19022\n", + "P12931 Q14289\n", + "P12931 P35222\n", + "P12931 O75553\n", + "P12931 P08581\n", + "P12931 Q15139\n", + "P12931 O60716\n", + "P12931 Q13177\n", + "P45983 P12931\n", + "P35222 P46531\n", + "O75553 P46531\n", + "Q14289 Q05397\n", + "P08581 Q05397\n", + "P12830 P35222\n", + "P08581 P12830\n", + "Q15139 P12830\n", + "O60716 P12830\n", + "P19022 P35222\n", + "O60716 P19022\n", + "Q13177 P08670\n", + "O95819 O43318\n", + "O95819 Q13233\n", + "Q15139 P35222\n", + "O43318 P45983\n", + "Q13233 P45983\n", + "looking for paths in the network with length: 0 for node SRC and LATS1\n", + "looking for paths in the network with length: 1 for node SRC and LATS1\n", + "looking for paths in the network with length: 2 for node SRC and LATS1\n", + "looking for paths in the network with length: 3 for node SRC and LATS1\n", + "looking for paths in the network with length: 4 for node SRC and LATS1\n", + "looking for paths in the network with length: 5 for node SRC and LATS1\n", + "looking for paths in the network with length: 6 for node SRC and LATS1\n", + "i_search = 3\n", + "Looking for paths with length: 0 for node SRC and LATS1\n", + "i_search = 3\n", + "Looking for paths with length: 1 for node SRC and LATS1\n", + "i_search = 3\n", + "Looking for paths with length: 2 for node SRC and LATS1\n", + "i_search = 3\n", + "Looking for paths with length: 3 for node SRC and LATS1\n", + "[['SRC', 'RAF1', 'STK3', 'LATS1'], ['SRC', 'RAF1', 'STK4', 'LATS1'], ['SRC', 'PAK2', 'NF2', 'LATS1']]\n", + "P12931 P04049\n", + "P04049 Q13188\n", + "Q13188 O95835\n", + "P12931 P04049\n", + "P04049 Q13043\n", + "Q13043 O95835\n", + "P12931 Q13177\n", + "Q13177 P35240\n", + "P35240 O95835\n", + "P12931 Q05397\n", + "P12931 P19022\n", + "P12931 Q14289\n", + "P12931 P35222\n", + "P12931 O75553\n", + "P12931 P08581\n", + "P12931 Q15139\n", + "P12931 O60716\n", + "P12931 Q13177\n", + "P45983 P12931\n", + "P12931 P04049\n", + "P35222 P46531\n", + "O75553 P46531\n", + "Q14289 Q05397\n", + "P08581 Q05397\n", + "P12830 P35222\n", + "P08581 P12830\n", + "Q15139 P12830\n", + "O60716 P12830\n", + "P19022 P35222\n", + "O60716 P19022\n", + "Q13177 P08670\n", + "O95819 O43318\n", + "O95819 Q13233\n", + "Q13188 O95835\n", + "Q13043 O95835\n", + "P35240 O95835\n", + "Q13188 Q9NRM7\n", + "Q13043 Q9NRM7\n", + "P35240 Q9NRM7\n", + "Q15139 P35222\n", + "Q13177 P04049\n", + "Q13177 P35240\n", + "O43318 P45983\n", + "Q13233 P45983\n", + "P45983 Q13043\n", + "P04049 Q13188\n", + "P04049 Q13043\n", + "P35240 Q13188\n", + "P35240 Q13043\n", + "looking for paths in the network with length: 0 for node SRC and LATS2\n", + "looking for paths in the network with length: 1 for node SRC and LATS2\n", + "looking for paths in the network with length: 2 for node SRC and LATS2\n", + "looking for paths in the network with length: 3 for node SRC and LATS2\n", + "Found a path!\n", + "[['SRC', 'PAK2', 'NF2', 'LATS2'], ['SRC', 'RAF1', 'STK3', 'LATS2'], ['SRC', 'RAF1', 'STK4', 'LATS2']]\n", + "looking for paths in the network with length: 0 for node SRC and PTK2B\n", + "looking for paths in the network with length: 1 for node SRC and PTK2B\n", + "Found a path!\n", + "[['SRC', 'PTK2B']]\n", + "looking for paths in the network with length: 0 for node NOTCH1 and PTK2\n", + "looking for paths in the network with length: 1 for node NOTCH1 and PTK2\n", + "looking for paths in the network with length: 2 for node NOTCH1 and PTK2\n", + "looking for paths in the network with length: 3 for node NOTCH1 and PTK2\n", + "looking for paths in the network with length: 4 for node NOTCH1 and PTK2\n", + "looking for paths in the network with length: 5 for node NOTCH1 and PTK2\n", + "looking for paths in the network with length: 6 for node NOTCH1 and PTK2\n", + "i_search = 3\n", + "Looking for paths with length: 0 for node NOTCH1 and PTK2\n", + "i_search = 3\n", + "Looking for paths with length: 1 for node NOTCH1 and PTK2\n", + "i_search = 3\n", + "Looking for paths with length: 2 for node NOTCH1 and PTK2\n", + "i_search = 3\n", + "Looking for paths with length: 3 for node NOTCH1 and PTK2\n", + "[['NOTCH1', 'SMAD3', 'BCAR1', 'PTK2'], ['NOTCH1', 'LCK', 'PTPRH', 'PTK2']]\n", + "P84022 P46531\n", + "P56945 P84022\n", + "Q05397 P56945\n", + "P06239 P46531\n", + "Q9HD43 P06239\n", + "Q9HD43 Q05397\n", + "P12931 Q05397\n", + "P12931 P19022\n", + "P12931 Q14289\n", + "P12931 P35222\n", + "P12931 O75553\n", + "P12931 P08581\n", + "P12931 Q15139\n", + "P12931 O60716\n", + "P12931 Q13177\n", + "P45983 P12931\n", + "P12931 P04049\n", + "P12931 P56945\n", + "Q9HD43 P12931\n", + "P35222 P46531\n", + "O75553 P46531\n", + "P84022 P46531\n", + "P06239 P46531\n", + "Q14289 Q05397\n", + "P08581 Q05397\n", + "Q05397 P56945\n", + "Q05397 Q9HD43\n", + "Q9HD43 Q05397\n", + "P12830 P35222\n", + "P08581 P12830\n", + "Q15139 P12830\n", + "O60716 P12830\n", + "P19022 P35222\n", + "O60716 P19022\n", + "Q13177 P08670\n", + "O95819 O43318\n", + "O95819 Q13233\n", + "Q13188 O95835\n", + "Q13043 O95835\n", + "P35240 O95835\n", + "Q13188 Q9NRM7\n", + "Q13043 Q9NRM7\n", + "P35240 Q9NRM7\n", + "Q15139 P35222\n", + "Q13177 P04049\n", + "Q13177 P35240\n", + "O43318 P45983\n", + "Q13233 P45983\n", + "P45983 Q13043\n", + "P45983 P84022\n", + "O43318 P84022\n", + "P04049 Q13188\n", + "P04049 Q13043\n", + "P06239 P04049\n", + "P35240 Q13188\n", + "P35240 Q13043\n", + "P56945 P84022\n", + "Q9HD43 P56945\n", + "Q9HD43 P06239\n", + "looking for paths in the network with length: 0 for node NOTCH1 and CDH1\n", + "looking for paths in the network with length: 1 for node NOTCH1 and CDH1\n", + "looking for paths in the network with length: 2 for node NOTCH1 and CDH1\n", + "Found a path!\n", + "[['NOTCH1', 'CTNNB1', 'CDH1']]\n", + "looking for paths in the network with length: 0 for node NOTCH1 and CDH2\n", + "looking for paths in the network with length: 1 for node NOTCH1 and CDH2\n", + "looking for paths in the network with length: 2 for node NOTCH1 and CDH2\n", + "Found a path!\n", + "[['NOTCH1', 'CTNNB1', 'CDH2']]\n", + "looking for paths in the network with length: 0 for node NOTCH1 and VIM\n", + "looking for paths in the network with length: 1 for node NOTCH1 and VIM\n", + "looking for paths in the network with length: 2 for node NOTCH1 and VIM\n", + "looking for paths in the network with length: 3 for node NOTCH1 and VIM\n", + "looking for paths in the network with length: 4 for node NOTCH1 and VIM\n", + "looking for paths in the network with length: 5 for node NOTCH1 and VIM\n", + "looking for paths in the network with length: 6 for node NOTCH1 and VIM\n", + "i_search = 3\n", + "Looking for paths with length: 0 for node NOTCH1 and VIM\n", + "i_search = 3\n", + "Looking for paths with length: 1 for node NOTCH1 and VIM\n", + "i_search = 3\n", + "Looking for paths with length: 2 for node NOTCH1 and VIM\n", + "i_search = 3\n", + "Looking for paths with length: 3 for node NOTCH1 and VIM\n", + "looking for paths in the network with length: 0 for node NOTCH1 and MAP4K4\n", + "looking for paths in the network with length: 1 for node NOTCH1 and MAP4K4\n", + "looking for paths in the network with length: 2 for node NOTCH1 and MAP4K4\n", + "looking for paths in the network with length: 3 for node NOTCH1 and MAP4K4\n", + "Found a path!\n", + "[['NOTCH1', 'SMAD3', 'MAP3K7', 'MAP4K4']]\n", + "looking for paths in the network with length: 0 for node NOTCH1 and LATS1\n", + "looking for paths in the network with length: 1 for node NOTCH1 and LATS1\n", + "looking for paths in the network with length: 2 for node NOTCH1 and LATS1\n", + "looking for paths in the network with length: 3 for node NOTCH1 and LATS1\n", + "looking for paths in the network with length: 4 for node NOTCH1 and LATS1\n", + "looking for paths in the network with length: 5 for node NOTCH1 and LATS1\n", + "looking for paths in the network with length: 6 for node NOTCH1 and LATS1\n", + "i_search = 3\n", + "Looking for paths with length: 0 for node NOTCH1 and LATS1\n", + "i_search = 3\n", + "Looking for paths with length: 1 for node NOTCH1 and LATS1\n", + "i_search = 3\n", + "Looking for paths with length: 2 for node NOTCH1 and LATS1\n", + "i_search = 3\n", + "Looking for paths with length: 3 for node NOTCH1 and LATS1\n", + "[['NOTCH1', 'SMAD3', 'WWTR1', 'LATS1'], ['NOTCH1', 'CTNNB1', 'YAP1', 'LATS1'], ['NOTCH1', 'RUNX2', 'WWTR1', 'LATS1'], ['NOTCH1', 'RUNX2', 'YAP1', 'LATS1']]\n", + "P84022 P46531\n", + "Q9GZV5 P84022\n", + "O95835 Q9GZV5\n", + "P35222 P46531\n", + "P46937 P35222\n", + "O95835 P46937\n", + "Q13950 P46531\n", + "Q9GZV5 Q13950\n", + "O95835 Q9GZV5\n", + "Q13950 P46531\n", + "P46937 Q13950\n", + "O95835 P46937\n", + "P12931 Q05397\n", + "P12931 P19022\n", + "P12931 Q14289\n", + "P12931 P35222\n", + "P12931 O75553\n", + "P12931 P08581\n", + "P12931 Q15139\n", + "P12931 O60716\n", + "P12931 Q13177\n", + "P45983 P12931\n", + "P12931 P04049\n", + "P12931 P56945\n", + "Q9HD43 P12931\n", + "P35222 P46531\n", + "O75553 P46531\n", + "P84022 P46531\n", + "P06239 P46531\n", + "Q13950 P46531\n", + "Q14289 Q05397\n", + "P08581 Q05397\n", + "Q05397 P56945\n", + "Q05397 Q9HD43\n", + "Q9HD43 Q05397\n", + "P12830 P35222\n", + "P08581 P12830\n", + "Q15139 P12830\n", + "O60716 P12830\n", + "P19022 P35222\n", + "O60716 P19022\n", + "Q13177 P08670\n", + "O95819 O43318\n", + "O95819 Q13233\n", + "Q13188 O95835\n", + "Q13043 O95835\n", + "P35240 O95835\n", + "O95835 Q9GZV5\n", + "O95835 P46937\n", + "Q13188 Q9NRM7\n", + "Q13043 Q9NRM7\n", + "P35240 Q9NRM7\n", + "Q9NRM7 Q9GZV5\n", + "Q9NRM7 P46937\n", + "Q15139 P35222\n", + "P46937 P35222\n", + "Q13177 P04049\n", + "Q13177 P35240\n", + "O43318 P45983\n", + "Q13233 P45983\n", + "P45983 Q13043\n", + "P45983 P84022\n", + "O43318 P84022\n", + "P04049 Q13188\n", + "P04049 Q13043\n", + "P06239 P04049\n", + "P35240 Q13188\n", + "P35240 Q13043\n", + "P56945 P84022\n", + "Q9GZV5 P84022\n", + "P84022 Q13950\n", + "Q9HD43 P56945\n", + "Q9HD43 P06239\n", + "Q9GZV5 Q13950\n", + "P46937 Q13950\n", + "looking for paths in the network with length: 0 for node NOTCH1 and LATS2\n", + "looking for paths in the network with length: 1 for node NOTCH1 and LATS2\n", + "looking for paths in the network with length: 2 for node NOTCH1 and LATS2\n", + "looking for paths in the network with length: 3 for node NOTCH1 and LATS2\n", + "Found a path!\n", + "[['NOTCH1', 'SMAD3', 'WWTR1', 'LATS2'], ['NOTCH1', 'CTNNB1', 'YAP1', 'LATS2'], ['NOTCH1', 'RUNX2', 'WWTR1', 'LATS2'], ['NOTCH1', 'RUNX2', 'YAP1', 'LATS2']]\n", + "looking for paths in the network with length: 0 for node NOTCH1 and PTK2B\n", + "looking for paths in the network with length: 1 for node NOTCH1 and PTK2B\n", + "looking for paths in the network with length: 2 for node NOTCH1 and PTK2B\n", + "looking for paths in the network with length: 3 for node NOTCH1 and PTK2B\n", + "looking for paths in the network with length: 4 for node NOTCH1 and PTK2B\n", + "Found a path!\n", + "[['NOTCH1', 'SMAD3', 'BCAR1', 'PTK2', 'PTK2B'], ['NOTCH1', 'LCK', 'PTPRH', 'PTK2', 'PTK2B']]\n", + "looking for paths in the network with length: 0 for node PTK2 and CDH1\n", + "looking for paths in the network with length: 1 for node PTK2 and CDH1\n", + "looking for paths in the network with length: 2 for node PTK2 and CDH1\n", + "looking for paths in the network with length: 3 for node PTK2 and CDH1\n", + "looking for paths in the network with length: 4 for node PTK2 and CDH1\n", + "Found a path!\n", + "[['PTK2', 'PTPRH', 'SRC', 'PRKD1', 'CDH1'], ['PTK2', 'PTPRH', 'SRC', 'CTNND1', 'CDH1'], ['PTK2', 'PTPRH', 'SRC', 'MET', 'CDH1']]\n", + "looking for paths in the network with length: 0 for node PTK2 and CDH2\n", + "looking for paths in the network with length: 1 for node PTK2 and CDH2\n", + "looking for paths in the network with length: 2 for node PTK2 and CDH2\n", + "looking for paths in the network with length: 3 for node PTK2 and CDH2\n", + "Found a path!\n", + "[['PTK2', 'PTPRH', 'SRC', 'CDH2']]\n", + "looking for paths in the network with length: 0 for node PTK2 and VIM\n", + "looking for paths in the network with length: 1 for node PTK2 and VIM\n", + "looking for paths in the network with length: 2 for node PTK2 and VIM\n", + "looking for paths in the network with length: 3 for node PTK2 and VIM\n", + "looking for paths in the network with length: 4 for node PTK2 and VIM\n", + "Found a path!\n", + "[['PTK2', 'PTPRH', 'SRC', 'PAK2', 'VIM']]\n", + "looking for paths in the network with length: 0 for node PTK2 and MAP4K4\n", + "looking for paths in the network with length: 1 for node PTK2 and MAP4K4\n", + "looking for paths in the network with length: 2 for node PTK2 and MAP4K4\n", + "looking for paths in the network with length: 3 for node PTK2 and MAP4K4\n", + "looking for paths in the network with length: 4 for node PTK2 and MAP4K4\n", + "Found a path!\n", + "[['PTK2', 'SRC', 'MAPK8', 'MAP3K7', 'MAP4K4'], ['PTK2', 'SRC', 'MAPK8', 'MAP3K1', 'MAP4K4']]\n", + "looking for paths in the network with length: 0 for node PTK2 and LATS1\n", + "looking for paths in the network with length: 1 for node PTK2 and LATS1\n", + "looking for paths in the network with length: 2 for node PTK2 and LATS1\n", + "looking for paths in the network with length: 3 for node PTK2 and LATS1\n", + "looking for paths in the network with length: 4 for node PTK2 and LATS1\n", + "looking for paths in the network with length: 5 for node PTK2 and LATS1\n", + "Found a path!\n", + "[['PTK2', 'PTPRH', 'SRC', 'PAK2', 'NF2', 'LATS1'], ['PTK2', 'PTPRH', 'SRC', 'RAF1', 'STK3', 'LATS1'], ['PTK2', 'PTPRH', 'SRC', 'RAF1', 'STK4', 'LATS1'], ['PTK2', 'PTPRH', 'LCK', 'RAF1', 'STK3', 'LATS1'], ['PTK2', 'PTPRH', 'LCK', 'RAF1', 'STK4', 'LATS1']]\n", + "looking for paths in the network with length: 0 for node PTK2 and LATS2\n", + "looking for paths in the network with length: 1 for node PTK2 and LATS2\n", + "looking for paths in the network with length: 2 for node PTK2 and LATS2\n", + "looking for paths in the network with length: 3 for node PTK2 and LATS2\n", + "looking for paths in the network with length: 4 for node PTK2 and LATS2\n", + "looking for paths in the network with length: 5 for node PTK2 and LATS2\n", + "Found a path!\n", + "[['PTK2', 'PTPRH', 'SRC', 'PAK2', 'NF2', 'LATS2'], ['PTK2', 'PTPRH', 'SRC', 'RAF1', 'STK3', 'LATS2'], ['PTK2', 'PTPRH', 'SRC', 'RAF1', 'STK4', 'LATS2'], ['PTK2', 'PTPRH', 'LCK', 'RAF1', 'STK3', 'LATS2'], ['PTK2', 'PTPRH', 'LCK', 'RAF1', 'STK4', 'LATS2']]\n", + "looking for paths in the network with length: 0 for node PTK2 and PTK2B\n", + "looking for paths in the network with length: 1 for node PTK2 and PTK2B\n", + "Found a path!\n", + "[['PTK2', 'PTK2B']]\n", + "looking for paths in the network with length: 0 for node CDH1 and CDH2\n", + "looking for paths in the network with length: 1 for node CDH1 and CDH2\n", + "looking for paths in the network with length: 2 for node CDH1 and CDH2\n", + "looking for paths in the network with length: 3 for node CDH1 and CDH2\n", + "looking for paths in the network with length: 4 for node CDH1 and CDH2\n", + "looking for paths in the network with length: 5 for node CDH1 and CDH2\n", + "looking for paths in the network with length: 6 for node CDH1 and CDH2\n", + "i_search = 3\n", + "Looking for paths with length: 0 for node CDH1 and CDH2\n", + "i_search = 3\n", + "Looking for paths with length: 1 for node CDH1 and CDH2\n", + "i_search = 3\n", + "Looking for paths with length: 2 for node CDH1 and CDH2\n", + "i_search = 3\n", + "Looking for paths with length: 3 for node CDH1 and CDH2\n", + "[['CDH1', 'EGFR', 'CTNND1', 'CDH2']]\n", + "P12830 P00533\n", + "P00533 O60716\n", + "O60716 P19022\n", + "P12931 Q05397\n", + "P12931 P19022\n", + "P12931 Q14289\n", + "P12931 P35222\n", + "P12931 O75553\n", + "P12931 P08581\n", + "P12931 Q15139\n", + "P12931 O60716\n", + "P12931 Q13177\n", + "P45983 P12931\n", + "P12931 P04049\n", + "P12931 P56945\n", + "Q9HD43 P12931\n", + "P12931 P00533\n", + "P35222 P46531\n", + "O75553 P46531\n", + "P84022 P46531\n", + "P06239 P46531\n", + "Q13950 P46531\n", + "Q14289 Q05397\n", + "P08581 Q05397\n", + "Q05397 P56945\n", + "Q05397 Q9HD43\n", + "Q9HD43 Q05397\n", + "P00533 Q05397\n", + "P12830 P35222\n", + "P08581 P12830\n", + "Q15139 P12830\n", + "O60716 P12830\n", + "P12830 P00533\n", + "P19022 P35222\n", + "O60716 P19022\n", + "Q13177 P08670\n", + "O95819 O43318\n", + "O95819 Q13233\n", + "Q13188 O95835\n", + "Q13043 O95835\n", + "P35240 O95835\n", + "O95835 Q9GZV5\n", + "O95835 P46937\n", + "Q13188 Q9NRM7\n", + "Q13043 Q9NRM7\n", + "P35240 Q9NRM7\n", + "Q9NRM7 Q9GZV5\n", + "Q9NRM7 P46937\n", + "Q14289 P00533\n", + "Q15139 P35222\n", + "P46937 P35222\n", + "P00533 P35222\n", + "Q15139 P00533\n", + "P00533 O60716\n", + "Q13177 P04049\n", + "Q13177 P35240\n", + "O43318 P45983\n", + "Q13233 P45983\n", + "P45983 Q13043\n", + "P45983 P84022\n", + "O43318 P84022\n", + "P04049 Q13188\n", + "P04049 Q13043\n", + "P06239 P04049\n", + "P35240 Q13188\n", + "P35240 Q13043\n", + "P56945 P84022\n", + "Q9GZV5 P84022\n", + "P84022 Q13950\n", + "Q9HD43 P56945\n", + "P00533 P56945\n", + "Q9HD43 P06239\n", + "Q9GZV5 Q13950\n", + "P46937 Q13950\n", + "looking for paths in the network with length: 0 for node CDH1 and VIM\n", + "looking for paths in the network with length: 1 for node CDH1 and VIM\n", + "looking for paths in the network with length: 2 for node CDH1 and VIM\n", + "looking for paths in the network with length: 3 for node CDH1 and VIM\n", + "looking for paths in the network with length: 4 for node CDH1 and VIM\n", + "looking for paths in the network with length: 5 for node CDH1 and VIM\n", + "looking for paths in the network with length: 6 for node CDH1 and VIM\n", + "Found a path!\n", + "[['CDH1', 'EGFR', 'PTK2', 'PTPRH', 'SRC', 'PAK2', 'VIM']]\n", + "looking for paths in the network with length: 0 for node CDH1 and MAP4K4\n", + "looking for paths in the network with length: 1 for node CDH1 and MAP4K4\n", + "looking for paths in the network with length: 2 for node CDH1 and MAP4K4\n", + "looking for paths in the network with length: 3 for node CDH1 and MAP4K4\n", + "looking for paths in the network with length: 4 for node CDH1 and MAP4K4\n", + "looking for paths in the network with length: 5 for node CDH1 and MAP4K4\n", + "Found a path!\n", + "[['CDH1', 'CTNND1', 'SRC', 'MAPK8', 'MAP3K7', 'MAP4K4'], ['CDH1', 'CTNND1', 'SRC', 'MAPK8', 'MAP3K1', 'MAP4K4'], ['CDH1', 'PRKD1', 'SRC', 'MAPK8', 'MAP3K7', 'MAP4K4'], ['CDH1', 'PRKD1', 'SRC', 'MAPK8', 'MAP3K1', 'MAP4K4'], ['CDH1', 'MET', 'SRC', 'MAPK8', 'MAP3K7', 'MAP4K4'], ['CDH1', 'MET', 'SRC', 'MAPK8', 'MAP3K1', 'MAP4K4']]\n", + "looking for paths in the network with length: 0 for node CDH1 and LATS1\n", + "looking for paths in the network with length: 1 for node CDH1 and LATS1\n", + "looking for paths in the network with length: 2 for node CDH1 and LATS1\n", + "looking for paths in the network with length: 3 for node CDH1 and LATS1\n", + "looking for paths in the network with length: 4 for node CDH1 and LATS1\n", + "looking for paths in the network with length: 5 for node CDH1 and LATS1\n", + "looking for paths in the network with length: 6 for node CDH1 and LATS1\n", + "i_search = 3\n", + "Looking for paths with length: 0 for node CDH1 and LATS1\n", + "i_search = 3\n", + "Looking for paths with length: 1 for node CDH1 and LATS1\n", + "i_search = 3\n", + "Looking for paths with length: 2 for node CDH1 and LATS1\n", + "i_search = 3\n", + "Looking for paths with length: 3 for node CDH1 and LATS1\n", + "looking for paths in the network with length: 0 for node CDH1 and LATS2\n", + "looking for paths in the network with length: 1 for node CDH1 and LATS2\n", + "looking for paths in the network with length: 2 for node CDH1 and LATS2\n", + "looking for paths in the network with length: 3 for node CDH1 and LATS2\n", + "looking for paths in the network with length: 4 for node CDH1 and LATS2\n", + "looking for paths in the network with length: 5 for node CDH1 and LATS2\n", + "looking for paths in the network with length: 6 for node CDH1 and LATS2\n", + "i_search = 3\n", + "Looking for paths with length: 0 for node CDH1 and LATS2\n", + "i_search = 3\n", + "Looking for paths with length: 1 for node CDH1 and LATS2\n", + "i_search = 3\n", + "Looking for paths with length: 2 for node CDH1 and LATS2\n", + "i_search = 3\n", + "Looking for paths with length: 3 for node CDH1 and LATS2\n", + "looking for paths in the network with length: 0 for node CDH1 and PTK2B\n", + "looking for paths in the network with length: 1 for node CDH1 and PTK2B\n", + "looking for paths in the network with length: 2 for node CDH1 and PTK2B\n", + "looking for paths in the network with length: 3 for node CDH1 and PTK2B\n", + "Found a path!\n", + "[['CDH1', 'CTNND1', 'EGFR', 'PTK2B']]\n", + "looking for paths in the network with length: 0 for node CDH2 and VIM\n", + "looking for paths in the network with length: 1 for node CDH2 and VIM\n", + "looking for paths in the network with length: 2 for node CDH2 and VIM\n", + "looking for paths in the network with length: 3 for node CDH2 and VIM\n", + "looking for paths in the network with length: 4 for node CDH2 and VIM\n", + "looking for paths in the network with length: 5 for node CDH2 and VIM\n", + "looking for paths in the network with length: 6 for node CDH2 and VIM\n", + "i_search = 3\n", + "Looking for paths with length: 0 for node CDH2 and VIM\n", + "i_search = 3\n", + "Looking for paths with length: 1 for node CDH2 and VIM\n", + "i_search = 3\n", + "Looking for paths with length: 2 for node CDH2 and VIM\n", + "i_search = 3\n", + "Looking for paths with length: 3 for node CDH2 and VIM\n", + "looking for paths in the network with length: 0 for node CDH2 and MAP4K4\n", + "looking for paths in the network with length: 1 for node CDH2 and MAP4K4\n", + "looking for paths in the network with length: 2 for node CDH2 and MAP4K4\n", + "looking for paths in the network with length: 3 for node CDH2 and MAP4K4\n", + "looking for paths in the network with length: 4 for node CDH2 and MAP4K4\n", + "Found a path!\n", + "[['CDH2', 'SRC', 'MAPK8', 'MAP3K7', 'MAP4K4'], ['CDH2', 'SRC', 'MAPK8', 'MAP3K1', 'MAP4K4']]\n", + "looking for paths in the network with length: 0 for node CDH2 and LATS1\n", + "looking for paths in the network with length: 1 for node CDH2 and LATS1\n", + "looking for paths in the network with length: 2 for node CDH2 and LATS1\n", + "looking for paths in the network with length: 3 for node CDH2 and LATS1\n", + "looking for paths in the network with length: 4 for node CDH2 and LATS1\n", + "looking for paths in the network with length: 5 for node CDH2 and LATS1\n", + "looking for paths in the network with length: 6 for node CDH2 and LATS1\n", + "i_search = 3\n", + "Looking for paths with length: 0 for node CDH2 and LATS1\n", + "i_search = 3\n", + "Looking for paths with length: 1 for node CDH2 and LATS1\n", + "i_search = 3\n", + "Looking for paths with length: 2 for node CDH2 and LATS1\n", + "i_search = 3\n", + "Looking for paths with length: 3 for node CDH2 and LATS1\n", + "looking for paths in the network with length: 0 for node CDH2 and LATS2\n", + "looking for paths in the network with length: 1 for node CDH2 and LATS2\n", + "looking for paths in the network with length: 2 for node CDH2 and LATS2\n", + "looking for paths in the network with length: 3 for node CDH2 and LATS2\n", + "looking for paths in the network with length: 4 for node CDH2 and LATS2\n", + "looking for paths in the network with length: 5 for node CDH2 and LATS2\n", + "looking for paths in the network with length: 6 for node CDH2 and LATS2\n", + "i_search = 3\n", + "Looking for paths with length: 0 for node CDH2 and LATS2\n", + "i_search = 3\n", + "Looking for paths with length: 1 for node CDH2 and LATS2\n", + "i_search = 3\n", + "Looking for paths with length: 2 for node CDH2 and LATS2\n", + "i_search = 3\n", + "Looking for paths with length: 3 for node CDH2 and LATS2\n", + "looking for paths in the network with length: 0 for node CDH2 and PTK2B\n", + "looking for paths in the network with length: 1 for node CDH2 and PTK2B\n", + "looking for paths in the network with length: 2 for node CDH2 and PTK2B\n", + "looking for paths in the network with length: 3 for node CDH2 and PTK2B\n", + "Found a path!\n", + "[['CDH2', 'CTNND1', 'EGFR', 'PTK2B']]\n", + "looking for paths in the network with length: 0 for node VIM and MAP4K4\n", + "looking for paths in the network with length: 1 for node VIM and MAP4K4\n", + "looking for paths in the network with length: 2 for node VIM and MAP4K4\n", + "looking for paths in the network with length: 3 for node VIM and MAP4K4\n", + "looking for paths in the network with length: 4 for node VIM and MAP4K4\n", + "looking for paths in the network with length: 5 for node VIM and MAP4K4\n", + "Found a path!\n", + "[['VIM', 'PAK2', 'SRC', 'MAPK8', 'MAP3K7', 'MAP4K4'], ['VIM', 'PAK2', 'SRC', 'MAPK8', 'MAP3K1', 'MAP4K4']]\n", + "looking for paths in the network with length: 0 for node VIM and LATS1\n", + "looking for paths in the network with length: 1 for node VIM and LATS1\n", + "looking for paths in the network with length: 2 for node VIM and LATS1\n", + "looking for paths in the network with length: 3 for node VIM and LATS1\n", + "looking for paths in the network with length: 4 for node VIM and LATS1\n", + "looking for paths in the network with length: 5 for node VIM and LATS1\n", + "looking for paths in the network with length: 6 for node VIM and LATS1\n", + "i_search = 3\n", + "Looking for paths with length: 0 for node VIM and LATS1\n", + "i_search = 3\n", + "Looking for paths with length: 1 for node VIM and LATS1\n", + "i_search = 3\n", + "Looking for paths with length: 2 for node VIM and LATS1\n", + "i_search = 3\n", + "Looking for paths with length: 3 for node VIM and LATS1\n", + "looking for paths in the network with length: 0 for node VIM and LATS2\n", + "looking for paths in the network with length: 1 for node VIM and LATS2\n", + "looking for paths in the network with length: 2 for node VIM and LATS2\n", + "looking for paths in the network with length: 3 for node VIM and LATS2\n", + "looking for paths in the network with length: 4 for node VIM and LATS2\n", + "looking for paths in the network with length: 5 for node VIM and LATS2\n", + "looking for paths in the network with length: 6 for node VIM and LATS2\n", + "i_search = 3\n", + "Looking for paths with length: 0 for node VIM and LATS2\n", + "i_search = 3\n", + "Looking for paths with length: 1 for node VIM and LATS2\n", + "i_search = 3\n", + "Looking for paths with length: 2 for node VIM and LATS2\n", + "i_search = 3\n", + "Looking for paths with length: 3 for node VIM and LATS2\n", + "looking for paths in the network with length: 0 for node VIM and PTK2B\n", + "looking for paths in the network with length: 1 for node VIM and PTK2B\n", + "looking for paths in the network with length: 2 for node VIM and PTK2B\n", + "looking for paths in the network with length: 3 for node VIM and PTK2B\n", + "looking for paths in the network with length: 4 for node VIM and PTK2B\n", + "looking for paths in the network with length: 5 for node VIM and PTK2B\n", + "Found a path!\n", + "[['VIM', 'PAK2', 'SRC', 'PTPRH', 'PTK2', 'PTK2B']]\n", + "looking for paths in the network with length: 0 for node MAP4K4 and LATS1\n", + "looking for paths in the network with length: 1 for node MAP4K4 and LATS1\n", + "looking for paths in the network with length: 2 for node MAP4K4 and LATS1\n", + "looking for paths in the network with length: 3 for node MAP4K4 and LATS1\n", + "looking for paths in the network with length: 4 for node MAP4K4 and LATS1\n", + "Found a path!\n", + "[['MAP4K4', 'MAP3K7', 'MAPK8', 'STK4', 'LATS1'], ['MAP4K4', 'MAP3K1', 'MAPK8', 'STK4', 'LATS1']]\n", + "looking for paths in the network with length: 0 for node MAP4K4 and LATS2\n", + "looking for paths in the network with length: 1 for node MAP4K4 and LATS2\n", + "looking for paths in the network with length: 2 for node MAP4K4 and LATS2\n", + "looking for paths in the network with length: 3 for node MAP4K4 and LATS2\n", + "looking for paths in the network with length: 4 for node MAP4K4 and LATS2\n", + "Found a path!\n", + "[['MAP4K4', 'MAP3K7', 'MAPK8', 'STK4', 'LATS2'], ['MAP4K4', 'MAP3K1', 'MAPK8', 'STK4', 'LATS2']]\n", + "looking for paths in the network with length: 0 for node MAP4K4 and PTK2B\n", + "looking for paths in the network with length: 1 for node MAP4K4 and PTK2B\n", + "looking for paths in the network with length: 2 for node MAP4K4 and PTK2B\n", + "looking for paths in the network with length: 3 for node MAP4K4 and PTK2B\n", + "looking for paths in the network with length: 4 for node MAP4K4 and PTK2B\n", + "Found a path!\n", + "[['MAP4K4', 'MAP3K7', 'MAPK8', 'SRC', 'PTK2B'], ['MAP4K4', 'MAP3K1', 'MAPK8', 'SRC', 'PTK2B']]\n", + "looking for paths in the network with length: 0 for node LATS1 and LATS2\n", + "looking for paths in the network with length: 1 for node LATS1 and LATS2\n", + "looking for paths in the network with length: 2 for node LATS1 and LATS2\n", + "looking for paths in the network with length: 3 for node LATS1 and LATS2\n", + "looking for paths in the network with length: 4 for node LATS1 and LATS2\n", + "looking for paths in the network with length: 5 for node LATS1 and LATS2\n", + "looking for paths in the network with length: 6 for node LATS1 and LATS2\n", + "i_search = 3\n", + "Looking for paths with length: 0 for node LATS1 and LATS2\n", + "i_search = 3\n", + "Looking for paths with length: 1 for node LATS1 and LATS2\n", + "i_search = 3\n", + "Looking for paths with length: 2 for node LATS1 and LATS2\n", + "i_search = 3\n", + "Looking for paths with length: 3 for node LATS1 and LATS2\n", + "looking for paths in the network with length: 0 for node LATS1 and PTK2B\n", + "looking for paths in the network with length: 1 for node LATS1 and PTK2B\n", + "looking for paths in the network with length: 2 for node LATS1 and PTK2B\n", + "looking for paths in the network with length: 3 for node LATS1 and PTK2B\n", + "looking for paths in the network with length: 4 for node LATS1 and PTK2B\n", + "looking for paths in the network with length: 5 for node LATS1 and PTK2B\n", + "looking for paths in the network with length: 6 for node LATS1 and PTK2B\n", + "Found a path!\n", + "[['LATS1', 'STK3', 'RAF1', 'LCK', 'PTPRH', 'PTK2', 'PTK2B'], ['LATS1', 'STK3', 'RAF1', 'SRC', 'PTPRH', 'PTK2', 'PTK2B'], ['LATS1', 'STK4', 'RAF1', 'LCK', 'PTPRH', 'PTK2', 'PTK2B'], ['LATS1', 'STK4', 'RAF1', 'SRC', 'PTPRH', 'PTK2', 'PTK2B'], ['LATS1', 'NF2', 'PAK2', 'SRC', 'PTPRH', 'PTK2', 'PTK2B']]\n", + "looking for paths in the network with length: 0 for node LATS2 and PTK2B\n", + "looking for paths in the network with length: 1 for node LATS2 and PTK2B\n", + "looking for paths in the network with length: 2 for node LATS2 and PTK2B\n", + "looking for paths in the network with length: 3 for node LATS2 and PTK2B\n", + "looking for paths in the network with length: 4 for node LATS2 and PTK2B\n", + "looking for paths in the network with length: 5 for node LATS2 and PTK2B\n", + "looking for paths in the network with length: 6 for node LATS2 and PTK2B\n", + "Found a path!\n", + "[['LATS2', 'STK3', 'RAF1', 'LCK', 'PTPRH', 'PTK2', 'PTK2B'], ['LATS2', 'STK3', 'RAF1', 'SRC', 'PTPRH', 'PTK2', 'PTK2B'], ['LATS2', 'STK4', 'RAF1', 'LCK', 'PTPRH', 'PTK2', 'PTK2B'], ['LATS2', 'STK4', 'RAF1', 'SRC', 'PTPRH', 'PTK2', 'PTK2B'], ['LATS2', 'NF2', 'PAK2', 'SRC', 'PTPRH', 'PTK2', 'PTK2B']]\n", + "CPU times: user 1min 50s, sys: 22.9 ms, total: 1min 50s\n", + "Wall time: 1min 50s\n" + ] + } + ], + "source": [ + "%%time\n", + "new_net1.complete_connection(mode=\"ALL\", maxlen=6, k_mean=\"tight\", only_signed=True, connect_node_when_first_introduced=True, consensus=True)" + ] + }, + { + "cell_type": "markdown", + "id": "c6510316-2f47-4e71-89e0-b93da0657897", + "metadata": {}, + "source": [ + "#### 4E. Visualize final network" + ] + }, + { + "cell_type": "code", + "execution_count": 9, + "id": "152b9434", + "metadata": {}, + "outputs": [ + { + "data": { + "image/svg+xml": [ + "\n", + "\n", + "\n", + "\n", + "\n", + "\n", + "%3\n", + "\n", + "\n", + "\n", + "SRC\n", + "\n", + "SRC\n", + "\n", + "\n", + "\n", + "PTK2\n", + "\n", + "PTK2\n", + "\n", + "\n", + "\n", + "SRC->PTK2\n", + "\n", + "\n", + "\n", + "\n", + "\n", + "CDH2\n", + "\n", + "CDH2\n", + "\n", + "\n", + "\n", + "SRC->CDH2\n", + "\n", + "\n", + "\n", + "\n", + "\n", + "\n", + "PTK2B\n", + "\n", + "PTK2B\n", + "\n", + "\n", + "\n", + "SRC->PTK2B\n", + "\n", + "\n", + "\n", + "\n", + "\n", + "CTNNB1\n", + "\n", + "CTNNB1\n", + "\n", + "\n", + "\n", + "SRC->CTNNB1\n", + "\n", + "\n", + "\n", + "\n", + "\n", + "DAB1\n", + "\n", + "DAB1\n", + "\n", + "\n", + "\n", + "SRC->DAB1\n", + "\n", + "\n", + "\n", + "\n", + "\n", + "MET\n", + "\n", + "MET\n", + "\n", + "\n", + "\n", + "SRC->MET\n", + "\n", + "\n", + "\n", + "\n", + "\n", + "\n", + "PRKD1\n", + "\n", + "PRKD1\n", + "\n", + "\n", + "\n", + "SRC->PRKD1\n", + "\n", + "\n", + "\n", + "\n", + "\n", + "CTNND1\n", + "\n", + "CTNND1\n", + "\n", + "\n", + "\n", + "SRC->CTNND1\n", + "\n", + "\n", + "\n", + "\n", + "\n", + "PAK2\n", + "\n", + "PAK2\n", + "\n", + "\n", + "\n", + "SRC->PAK2\n", + "\n", + "\n", + "\n", + "\n", + "\n", + "RAF1\n", + "\n", + "RAF1\n", + "\n", + "\n", + "\n", + "SRC->RAF1\n", + "\n", + "\n", + "\n", + "\n", + "\n", + "BCAR1\n", + "\n", + "BCAR1\n", + "\n", + "\n", + "\n", + "SRC->BCAR1\n", + "\n", + "\n", + "\n", + "\n", + "\n", + "EGFR\n", + "\n", + "EGFR\n", + "\n", + "\n", + "\n", + "SRC->EGFR\n", + "\n", + "\n", + "\n", + "\n", + "\n", + "PTK2->BCAR1\n", + "\n", + "\n", + "\n", + "\n", + "\n", + "PTPRH\n", + "\n", + "PTPRH\n", + "\n", + "\n", + "\n", + "PTK2->PTPRH\n", + "\n", + "\n", + "\n", + "\n", + "\n", + "\n", + "CDH2->CTNNB1\n", + "\n", + "\n", + "\n", + "\n", + "\n", + "PTK2B->PTK2\n", + "\n", + "\n", + "\n", + "\n", + "\n", + "PTK2B->EGFR\n", + "\n", + "\n", + "\n", + "\n", + "\n", + "NOTCH1\n", + "\n", + "NOTCH1\n", + "\n", + "\n", + "\n", + "CTNNB1->NOTCH1\n", + "\n", + "\n", + "\n", + "\n", + "\n", + "DAB1->NOTCH1\n", + "\n", + "\n", + "\n", + "\n", + "\n", + "CDH1\n", + "\n", + "CDH1\n", + "\n", + "\n", + "\n", + "CDH1->CTNNB1\n", + "\n", + "\n", + "\n", + "\n", + "\n", + "CDH1->EGFR\n", + "\n", + "\n", + "\n", + "\n", + "\n", + "MET->PTK2\n", + "\n", + "\n", + "\n", + "\n", + "\n", + "MET->CDH1\n", + "\n", + "\n", + "\n", + "\n", + "\n", + "PRKD1->CTNNB1\n", + "\n", + "\n", + "\n", + "\n", + "\n", + "PRKD1->CDH1\n", + "\n", + "\n", + "\n", + "\n", + "\n", + "PRKD1->EGFR\n", + "\n", + "\n", + "\n", + "\n", + "\n", + "CTNND1->CDH2\n", + "\n", + "\n", + "\n", + "\n", + "\n", + "CTNND1->CDH1\n", + "\n", + "\n", + "\n", + "\n", + "\n", + "VIM\n", + "\n", + "VIM\n", + "\n", + "\n", + "\n", + "PAK2->VIM\n", + "\n", + "\n", + "\n", + "\n", + "\n", + "\n", + "PAK2->RAF1\n", + "\n", + "\n", + "\n", + "\n", + "\n", + "NF2\n", + "\n", + "NF2\n", + "\n", + "\n", + "\n", + "PAK2->NF2\n", + "\n", + "\n", + "\n", + "\n", + "\n", + "MAPK8\n", + "\n", + "MAPK8\n", + "\n", + "\n", + "\n", + "MAPK8->SRC\n", + "\n", + "\n", + "\n", + "\n", + "\n", + "STK4\n", + "\n", + "STK4\n", + "\n", + "\n", + "\n", + "MAPK8->STK4\n", + "\n", + "\n", + "\n", + "\n", + "\n", + "SMAD3\n", + "\n", + "SMAD3\n", + "\n", + "\n", + "\n", + "MAPK8->SMAD3\n", + "\n", + "\n", + "\n", + "\n", + "\n", + "MAP3K7\n", + "\n", + "MAP3K7\n", + "\n", + "\n", + "\n", + "MAP3K7->MAPK8\n", + "\n", + "\n", + "\n", + "\n", + "\n", + "MAP3K7->SMAD3\n", + "\n", + "\n", + "\n", + "\n", + "\n", + "\n", + "MAP4K4\n", + "\n", + "MAP4K4\n", + "\n", + "\n", + "\n", + "MAP4K4->MAP3K7\n", + "\n", + "\n", + "\n", + "\n", + "\n", + "MAP3K1\n", + "\n", + "MAP3K1\n", + "\n", + "\n", + "\n", + "MAP4K4->MAP3K1\n", + "\n", + "\n", + "\n", + "\n", + "\n", + "MAP3K1->MAPK8\n", + "\n", + "\n", + "\n", + "\n", + "\n", + "STK3\n", + "\n", + "STK3\n", + "\n", + "\n", + "\n", + "RAF1->STK3\n", + "\n", + "\n", + "\n", + "\n", + "\n", + "\n", + "RAF1->STK4\n", + "\n", + "\n", + "\n", + "\n", + "\n", + "\n", + "LATS1\n", + "\n", + "LATS1\n", + "\n", + "\n", + "\n", + "STK3->LATS1\n", + "\n", + "\n", + "\n", + "\n", + "\n", + "LATS2\n", + "\n", + "LATS2\n", + "\n", + "\n", + "\n", + "STK3->LATS2\n", + "\n", + "\n", + "\n", + "\n", + "\n", + "WWTR1\n", + "\n", + "WWTR1\n", + "\n", + "\n", + "\n", + "LATS1->WWTR1\n", + "\n", + "\n", + "\n", + "\n", + "\n", + "\n", + "YAP1\n", + "\n", + "YAP1\n", + "\n", + "\n", + "\n", + "LATS1->YAP1\n", + "\n", + "\n", + "\n", + "\n", + "\n", + "STK4->LATS1\n", + "\n", + "\n", + "\n", + "\n", + "\n", + "STK4->LATS2\n", + "\n", + "\n", + "\n", + "\n", + "\n", + "NF2->STK3\n", + "\n", + "\n", + "\n", + "\n", + "\n", + "NF2->LATS1\n", + "\n", + "\n", + "\n", + "\n", + "\n", + "NF2->STK4\n", + "\n", + "\n", + "\n", + "\n", + "\n", + "NF2->LATS2\n", + "\n", + "\n", + "\n", + "\n", + "\n", + "LATS2->WWTR1\n", + "\n", + "\n", + "\n", + "\n", + "\n", + "\n", + "LATS2->YAP1\n", + "\n", + "\n", + "\n", + "\n", + "\n", + "\n", + "SMAD3->NOTCH1\n", + "\n", + "\n", + "\n", + "\n", + "\n", + "RUNX2\n", + "\n", + "RUNX2\n", + "\n", + "\n", + "\n", + "SMAD3->RUNX2\n", + "\n", + "\n", + "\n", + "\n", + "\n", + "\n", + "BCAR1->SMAD3\n", + "\n", + "\n", + "\n", + "\n", + "\n", + "\n", + "LCK\n", + "\n", + "LCK\n", + "\n", + "\n", + "\n", + "LCK->NOTCH1\n", + "\n", + "\n", + "\n", + "\n", + "\n", + "LCK->RAF1\n", + "\n", + "\n", + "\n", + "\n", + "\n", + "PTPRH->SRC\n", + "\n", + "\n", + "\n", + "\n", + "\n", + "\n", + "PTPRH->PTK2\n", + "\n", + "\n", + "\n", + "\n", + "\n", + "\n", + "PTPRH->BCAR1\n", + "\n", + "\n", + "\n", + "\n", + "\n", + "\n", + "PTPRH->LCK\n", + "\n", + "\n", + "\n", + "\n", + "\n", + "\n", + "WWTR1->SMAD3\n", + "\n", + "\n", + "\n", + "\n", + "\n", + "WWTR1->RUNX2\n", + "\n", + "\n", + "\n", + "\n", + "\n", + "YAP1->CTNNB1\n", + "\n", + "\n", + "\n", + "\n", + "\n", + "YAP1->RUNX2\n", + "\n", + "\n", + "\n", + "\n", + "\n", + "\n", + "RUNX2->NOTCH1\n", + "\n", + "\n", + "\n", + "\n", + "\n", + "\n", + "EGFR->PTK2\n", + "\n", + "\n", + "\n", + "\n", + "\n", + "EGFR->CTNNB1\n", + "\n", + "\n", + "\n", + "\n", + "\n", + "EGFR->CTNND1\n", + "\n", + "\n", + "\n", + "\n", + "\n", + "\n", + "EGFR->BCAR1\n", + "\n", + "\n", + "\n", + "\n", + "\n", + "\n" + ], + "text/plain": [ + "" + ] + }, + "metadata": {}, + "output_type": "display_data" + } + ], + "source": [ + "#Visualize network\n", + "visualizer1 = NetworkVisualizer(new_net1, color_by='effect')\n", + "visualizer1.render(output_file='network2')" + ] + }, + { + "cell_type": "code", + "execution_count": null, + "id": "80b84e81-abc2-4aae-ad1c-3ebf00355b98", + "metadata": {}, + "outputs": [], + "source": [ + "#Visualize a specific nodes and \n", + "visualizer1 = NetworkVisualizer(new_net1, predefined_node = \"SRC\",color_by='effect')\n", + "visualizer1.render(output_file='network2')" + ] + }, + { + "cell_type": "code", + "execution_count": 15, + "id": "0aa6d076-5310-462e-aa0e-f69da822b962", + "metadata": {}, + "outputs": [ + { + "data": { + "text/html": [ + "
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sourcetargetTypeEffectReferences
6821P12931Q05397NonestimulationAdhesome:10085298;Adhesome:10592173;Adhesome:1...
32968P12931P19022NoneinhibitionACSN:15782139;ACSN:16371504;ACSN:16492141;ACSN...
5154P12931Q14289NonestimulationAdhesome:10329689;Adhesome:10521452;Adhesome:1...
44795Q14289Q05397NonestimulationAdhesome:16760434;HPRD:16760434;KEA:12960434;K...
11582P12931P35222NonestimulationACSN:10593980;ACSN:12123611;ACSN:15782139;ACSN...
..................
67482P00533Q05397NonestimulationACSN:10545505;ACSN:16919435;ACSN:17496910;ACSN...
7631Q14289P00533NonestimulationCA1:11274221;HPRD:10777553;InnateDB:14963038;S...
73973P00533P35222NonestimulationACSN:12040186;ACSN:14585353;ACSN:17496910;ACSN...
2907Q15139P00533NonestimulationCancerCellMap:10523301;CancerCellMap:2984676;C...
78053P00533P56945NoneinhibitionKEA:17570479;ProtMapper:15951569;SPIKE_LC:1714...
\n", + "

71 rows × 5 columns

\n", + "
" + ], + "text/plain": [ + " source target Type Effect \\\n", + "6821 P12931 Q05397 None stimulation \n", + "32968 P12931 P19022 None inhibition \n", + "5154 P12931 Q14289 None stimulation \n", + "44795 Q14289 Q05397 None stimulation \n", + "11582 P12931 P35222 None stimulation \n", + "... ... ... ... ... \n", + "67482 P00533 Q05397 None stimulation \n", + "7631 Q14289 P00533 None stimulation \n", + "73973 P00533 P35222 None stimulation \n", + "2907 Q15139 P00533 None stimulation \n", + "78053 P00533 P56945 None inhibition \n", + "\n", + " References \n", + "6821 Adhesome:10085298;Adhesome:10592173;Adhesome:1... \n", + "32968 ACSN:15782139;ACSN:16371504;ACSN:16492141;ACSN... \n", + "5154 Adhesome:10329689;Adhesome:10521452;Adhesome:1... \n", + "44795 Adhesome:16760434;HPRD:16760434;KEA:12960434;K... \n", + "11582 ACSN:10593980;ACSN:12123611;ACSN:15782139;ACSN... \n", + "... ... \n", + "67482 ACSN:10545505;ACSN:16919435;ACSN:17496910;ACSN... \n", + "7631 CA1:11274221;HPRD:10777553;InnateDB:14963038;S... \n", + "73973 ACSN:12040186;ACSN:14585353;ACSN:17496910;ACSN... \n", + "2907 CancerCellMap:10523301;CancerCellMap:2984676;C... \n", + "78053 KEA:17570479;ProtMapper:15951569;SPIKE_LC:1714... \n", + "\n", + "[71 rows x 5 columns]" + ] + }, + "execution_count": 15, + "metadata": {}, + "output_type": "execute_result" + } + ], + "source": [ + "#We can access to the edges of the network\n", + "new_net1.edges" + ] + }, + { + "cell_type": "code", + "execution_count": 14, + "id": "6762228b-7e6c-4711-a07a-660c77f406e5", + "metadata": {}, + "outputs": [ + { + "data": { + "image/svg+xml": [ + "\n", + "\n", + "\n", + "\n", + "\n", + "\n", + "%3\n", + "\n", + "\n", + "\n", + "CDH1\n", + "\n", + "CDH1\n", + "\n", + "\n", + "\n", + "EGFR\n", + "\n", + "EGFR\n", + "\n", + "\n", + "\n", + "CDH1->EGFR\n", + "\n", + "\n", + "\n", + "\n", + "\n", + "CTNND1\n", + "\n", + "CTNND1\n", + "\n", + "\n", + "\n", + "EGFR->CTNND1\n", + "\n", + "\n", + "\n", + "\n", + "\n", + "\n", + "PTK2\n", + "\n", + "PTK2\n", + "\n", + "\n", + "\n", + "EGFR->PTK2\n", + "\n", + "\n", + "\n", + "\n", + "\n", + "CTNNB1\n", + "\n", + "CTNNB1\n", + "\n", + "\n", + "\n", + "EGFR->CTNNB1\n", + "\n", + "\n", + "\n", + "\n", + "\n", + "BCAR1\n", + "\n", + "BCAR1\n", + "\n", + "\n", + "\n", + "EGFR->BCAR1\n", + "\n", + "\n", + "\n", + "\n", + "\n", + "\n", + "SRC\n", + "\n", + "SRC\n", + "\n", + "\n", + "\n", + "SRC->EGFR\n", + "\n", + "\n", + "\n", + "\n", + "\n", + "PTK2B\n", + "\n", + "PTK2B\n", + "\n", + "\n", + "\n", + "PTK2B->EGFR\n", + "\n", + "\n", + "\n", + "\n", + "\n", + "PRKD1\n", + "\n", + "PRKD1\n", + "\n", + "\n", + "\n", + "PRKD1->EGFR\n", + "\n", + "\n", + "\n", + "\n", + "\n" + ], + "text/plain": [ + "" + ] + }, + "metadata": {}, + "output_type": "display_data" + } + ], + "source": [ + "visualizer = NetworkVisualizer(new_net1, predefined_node=\"EGFR\",color_by='effect')\n", + "visualizer.render()" + ] + }, + { + "cell_type": "markdown", + "id": "0e6e1986", + "metadata": {}, + "source": [ + "### Now we create the network with a similar list of genes but specifying the Resource object" + ] + }, + { + "cell_type": "code", + "execution_count": 15, + "id": "7401c535", + "metadata": {}, + "outputs": [], + "source": [ + "genes = [\"SRC\", \"NOTCH1\", \"PTK2\", \"CDH1\", \"CDH2\", \"VIM\", \"MAP4K4\", \"PTK2B\", \"COL1A1\"]" + ] + }, + { + "cell_type": "code", + "execution_count": 17, + "id": "60fcff6d", + "metadata": {}, + "outputs": [ + { + "name": "stdout", + "output_type": "stream", + "text": [ + "CPU times: user 22.9 ms, sys: 3.98 ms, total: 26.9 ms\n", + "Wall time: 25.7 ms\n" + ] + } + ], + "source": [ + "%%time\n", + "new_net1 = Network(genes, resources=resources.interactions)" + ] + }, + { + "cell_type": "code", + "execution_count": 18, + "id": "370180cc", + "metadata": { + "scrolled": true + }, + "outputs": [ + { + "name": "stdout", + "output_type": "stream", + "text": [ + "P12931 Q05397\n", + "P12830 P12931\n", + "P12931 P19022\n", + "P12931 Q14289\n", + "P02452 P12931\n", + "P46531 P19022\n", + "P46531 P02452\n", + "Q14289 Q05397\n", + "CPU times: user 1.34 s, sys: 19.9 ms, total: 1.36 s\n", + "Wall time: 1.36 s\n" + ] + } + ], + "source": [ + "%%time\n", + "new_net1.connect_nodes(only_signed=True, consensus_only=True)" + ] + }, + { + "cell_type": "code", + "execution_count": 19, + "id": "8ffecf5c", + "metadata": {}, + "outputs": [ + { + "name": "stdout", + "output_type": "stream", + "text": [ + "looking for paths in the network with length: 0 for node SRC and NOTCH1\n", + "looking for paths in the network with length: 1 for node SRC and NOTCH1\n", + "looking for paths in the network with length: 2 for node SRC and NOTCH1\n", + "Found a path!\n", + "[['SRC', 'COL1A1', 'NOTCH1']]\n", + "looking for paths in the network with length: 0 for node SRC and PTK2\n", + "looking for paths in the network with length: 1 for node SRC and PTK2\n", + "Found a path!\n", + "[['SRC', 'PTK2']]\n", + "looking for paths in the network with length: 0 for node SRC and CDH1\n", + "looking for paths in the network with length: 1 for node SRC and CDH1\n", + "Found a path!\n", + "[['SRC', 'CDH1']]\n", + "looking for paths in the network with length: 0 for node SRC and CDH2\n", + "looking for paths in the network with length: 1 for node SRC and CDH2\n", + "Found a path!\n", + "[['SRC', 'CDH2']]\n", + "looking for paths in the network with length: 0 for node SRC and VIM\n", + "looking for paths in the network with length: 1 for node SRC and VIM\n", + "looking for paths in the network with length: 2 for node SRC and VIM\n", + "looking for paths in the network with length: 3 for node SRC and VIM\n", + "i_search = 3\n", + "Looking for paths with length: 0 for node SRC and VIM\n", + "i_search = 3\n", + "Looking for paths with length: 1 for node SRC and VIM\n", + "i_search = 3\n", + "Looking for paths with length: 2 for node SRC and VIM\n", + "[['SRC', 'TCF7L2', 'VIM'], ['SRC', 'NFKB1', 'VIM'], ['SRC', 'HNF4A', 'VIM'], ['SRC', 'HIPK2', 'VIM'], ['SRC', 'STAT5A', 'VIM']]\n", + "P12931 Q9NQB0\n", + "Q9NQB0 P08670\n", + "P12931 P19838\n", + "P19838 P08670\n", + "P12931 P41235\n", + "P41235 P08670\n", + "P12931 Q9H2X6\n", + "Q9H2X6 P08670\n", + "P12931 P42229\n", + "P42229 P08670\n", + "P12931 Q05397\n", + "P12830 P12931\n", + "P12931 P19022\n", + "P12931 Q14289\n", + "P02452 P12931\n", + "P12931 Q9NQB0\n", + "P12931 P19838\n", + "P12931 P41235\n", + "P41235 P12931\n", + "P12931 Q9H2X6\n", + "P12931 P42229\n", + "P46531 P19022\n", + "P46531 P02452\n", + "P46531 P19838\n", + "Q14289 Q05397\n", + "Q9NQB0 P08670\n", + "P19838 P08670\n", + "P41235 P08670\n", + "Q9H2X6 P08670\n", + "P42229 P08670\n", + "P19838 P02452\n", + "P41235 Q9NQB0\n", + "P19838 P42229\n", + "looking for paths in the network with length: 0 for node SRC and MAP4K4\n", + "looking for paths in the network with length: 1 for node SRC and MAP4K4\n", + "looking for paths in the network with length: 2 for node SRC and MAP4K4\n", + "looking for paths in the network with length: 3 for node SRC and MAP4K4\n", + "i_search = 3\n", + "Looking for paths with length: 0 for node SRC and MAP4K4\n", + "i_search = 3\n", + "Looking for paths with length: 1 for node SRC and MAP4K4\n", + "i_search = 3\n", + "Looking for paths with length: 2 for node SRC and MAP4K4\n", + "[['SRC', 'EPHB1', 'MAP4K4'], ['SRC', 'PPARG', 'MAP4K4']]\n", + "P12931 P54762\n", + "P54762 O95819\n", + "P12931 P37231\n", + "P37231 O95819\n", + "P12931 Q05397\n", + "P12830 P12931\n", + "P12931 P19022\n", + "P12931 Q14289\n", + "P02452 P12931\n", + "P12931 Q9NQB0\n", + "P12931 P19838\n", + "P12931 P41235\n", + "P41235 P12931\n", + "P12931 Q9H2X6\n", + "P12931 P42229\n", + "P12931 P54762\n", + "P54762 P12931\n", + "P12931 P37231\n", + "P46531 P19022\n", + "P46531 P02452\n", + "P46531 P19838\n", + "P46531 P37231\n", + "Q14289 Q05397\n", + "P54762 Q05397\n", + "P37231 P12830\n", + "P37231 P19022\n", + "Q9NQB0 P08670\n", + "P19838 P08670\n", + "P41235 P08670\n", + "Q9H2X6 P08670\n", + "P42229 P08670\n", + "P54762 O95819\n", + "P37231 O95819\n", + "P19838 P02452\n", + "P41235 Q9NQB0\n", + "P19838 P42229\n", + "P37231 P19838\n", + "P37231 P42229\n", + "looking for paths in the network with length: 0 for node SRC and PTK2B\n", + "looking for paths in the network with length: 1 for node SRC and PTK2B\n", + "Found a path!\n", + "[['SRC', 'PTK2B']]\n", + "looking for paths in the network with length: 0 for node SRC and COL1A1\n", + "looking for paths in the network with length: 1 for node SRC and COL1A1\n", + "Found a path!\n", + "[['SRC', 'COL1A1']]\n", + "looking for paths in the network with length: 0 for node NOTCH1 and PTK2\n", + "looking for paths in the network with length: 1 for node NOTCH1 and PTK2\n", + "looking for paths in the network with length: 2 for node NOTCH1 and PTK2\n", + "looking for paths in the network with length: 3 for node NOTCH1 and PTK2\n", + "Found a path!\n", + "[['NOTCH1', 'COL1A1', 'SRC', 'PTK2']]\n", + "looking for paths in the network with length: 0 for node NOTCH1 and CDH1\n", + "looking for paths in the network with length: 1 for node NOTCH1 and CDH1\n", + "looking for paths in the network with length: 2 for node NOTCH1 and CDH1\n", + "Found a path!\n", + "[['NOTCH1', 'PPARG', 'CDH1']]\n", + "looking for paths in the network with length: 0 for node NOTCH1 and CDH2\n", + "looking for paths in the network with length: 1 for node NOTCH1 and CDH2\n", + "Found a path!\n", + "[['NOTCH1', 'CDH2']]\n", + "looking for paths in the network with length: 0 for node NOTCH1 and VIM\n", + "looking for paths in the network with length: 1 for node NOTCH1 and VIM\n", + "looking for paths in the network with length: 2 for node NOTCH1 and VIM\n", + "Found a path!\n", + "[['NOTCH1', 'NFKB1', 'VIM']]\n", + "looking for paths in the network with length: 0 for node NOTCH1 and MAP4K4\n", + "looking for paths in the network with length: 1 for node NOTCH1 and MAP4K4\n", + "looking for paths in the network with length: 2 for node NOTCH1 and MAP4K4\n", + "Found a path!\n", + "[['NOTCH1', 'PPARG', 'MAP4K4']]\n", + "looking for paths in the network with length: 0 for node NOTCH1 and PTK2B\n", + "looking for paths in the network with length: 1 for node NOTCH1 and PTK2B\n", + "looking for paths in the network with length: 2 for node NOTCH1 and PTK2B\n", + "looking for paths in the network with length: 3 for node NOTCH1 and PTK2B\n", + "Found a path!\n", + "[['NOTCH1', 'COL1A1', 'SRC', 'PTK2B']]\n", + "looking for paths in the network with length: 0 for node NOTCH1 and COL1A1\n", + "looking for paths in the network with length: 1 for node NOTCH1 and COL1A1\n", + "Found a path!\n", + "[['NOTCH1', 'COL1A1']]\n", + "looking for paths in the network with length: 0 for node PTK2 and CDH1\n", + "looking for paths in the network with length: 1 for node PTK2 and CDH1\n", + "looking for paths in the network with length: 2 for node PTK2 and CDH1\n", + "Found a path!\n", + "[['PTK2', 'SRC', 'CDH1']]\n", + "looking for paths in the network with length: 0 for node PTK2 and CDH2\n", + "looking for paths in the network with length: 1 for node PTK2 and CDH2\n", + "looking for paths in the network with length: 2 for node PTK2 and CDH2\n", + "looking for paths in the network with length: 3 for node PTK2 and CDH2\n", + "i_search = 3\n", + "Looking for paths with length: 0 for node PTK2 and CDH2\n", + "i_search = 3\n", + "Looking for paths with length: 1 for node PTK2 and CDH2\n", + "i_search = 3\n", + "Looking for paths with length: 2 for node PTK2 and CDH2\n", + "i_search = 3\n", + "Looking for paths with length: 3 for node PTK2 and CDH2\n", + "[['PTK2', 'ZYX', 'SRC', 'CDH2'], ['PTK2', 'STAT1', 'SMAD7', 'CDH2'], ['PTK2', 'STAT1', 'ABL1', 'CDH2'], ['PTK2', 'STAT1', 'JUN', 'CDH2'], ['PTK2', 'STAT1', 'MYC', 'CDH2'], ['PTK2', 'STAT1', 'COMPLEX:P19838_Q04206', 'CDH2'], ['PTK2', 'STAT1', 'WT1', 'CDH2'], ['PTK2', 'STAT1', 'MET', 'CDH2'], ['PTK2', 'ACTN3', 'SRC', 'CDH2'], ['PTK2', 'PIK3CG', 'AR', 'CDH2'], ['PTK2', 'MITF', 'MET', 'CDH2'], ['PTK2', 'MITF', 'PAX6', 'CDH2'], ['PTK2', 'IL6', 'MET', 'CDH2'], ['PTK2', 'CDC42', 'CTNND1', 'CDH2'], ['PTK2', 'ASAP1', 'AR', 'CDH2'], ['PTK2', 'RAP1B', 'CTNND1', 'CDH2'], ['PTK2', 'SMAD4', 'MSX1', 'CDH2'], ['PTK2', 'SMAD4', 'PPARG', 'CDH2'], ['PTK2', 'SMAD4', 'MYC', 'CDH2'], ['PTK2', 'SMAD4', 'SMAD7', 'CDH2'], ['PTK2', 'SMAD4', 'SOX9', 'CDH2'], ['PTK2', 'SMAD4', 'MET', 'CDH2'], ['PTK2', 'SMAD4', 'MMP2', 'CDH2'], ['PTK2', 'ITGB4', 'SRC', 'CDH2'], ['PTK2', 'ACTN4', 'SRC', 'CDH2'], ['PTK2', 'PTPN13', 'SRC', 'CDH2'], ['PTK2', 'PTPN13', 'MET', 'CDH2'], ['PTK2', 'TXN', 'PTPN1', 'CDH2'], ['PTK2', 'MAPK12', 'JUN', 'CDH2'], ['PTK2', 'MAPK12', 'MYC', 'CDH2'], ['PTK2', 'NCOA1', 'SRC', 'CDH2'], ['PTK2', 'NCOA1', 'STAT3', 'CDH2'], ['PTK2', 'NCOA1', 'PAWR', 'CDH2'], ['PTK2', 'NCOA1', 'MMP2', 'CDH2'], ['PTK2', 'ROCK1', 'RAC1', 'CDH2'], ['PTK2', 'ROCK1', 'CTNNB1', 'CDH2'], ['PTK2', 'MYCN', 'CTNNB1', 'CDH2'], ['PTK2', 'CEBPA', 'CTNNB1', 'CDH2'], ['PTK2', 'PIK3CB', 'PIK3R1', 'CDH2'], ['PTK2', 'PIK3CB', 'RHOA', 'CDH2'], ['PTK2', 'CAPN2', 'CTNNB1', 'CDH2'], ['PTK2', 'EPHB2', 'CTNNB1', 'CDH2'], ['PTK2', 'PIK3R5', 'RAC1', 'CDH2'], ['PTK2', 'CASP7', 'CTNNB1', 'CDH2'], ['PTK2', 'CDK5', 'RAC1', 'CDH2'], ['PTK2', 'ECM1', 'RAC1', 'CDH2'], ['PTK2', 'ECM1', 'CTNNB1', 'CDH2'], ['PTK2', 'KDR', 'RAC1', 'CDH2'], ['PTK2', 'SOS1', 'PIK3CA', 'CDH2'], ['PTK2', 'SOS1', 'RHOA', 'CDH2'], ['PTK2', 'VEGFA', 'RAC1', 'CDH2'], ['PTK2', 'VEGFA', 'CTNNB1', 'CDH2'], ['PTK2', 'ITGA4', 'RHOA', 'CDH2'], ['PTK2', 'EGFR', 'CDC42', 'CDH2'], ['PTK2', 'SDC4', 'MMP9', 'CDH2'], ['PTK2', 'PECAM1', 'FER', 'CDH2'], ['PTK2', 'PPARD', 'CTNNB1', 'CDH2'], ['PTK2', 'PIK3CG', 'PIK3R1', 'CDH2'], ['PTK2', 'RPS6KB1', 'PIK3R1', 'CDH2'], ['PTK2', 'PIK3R3', 'RAC1', 'CDH2'], ['PTK2', 'EFNA1', 'CTNNB1', 'CDH2'], ['PTK2', 'CASP3', 'CTNNB1', 'CDH2'], ['PTK2', 'PIK3CD', 'PIK3R1', 'CDH2'], ['PTK2', 'PIK3CD', 'RAC1', 'CDH2'], ['PTK2', 'CXCL12', 'CTNNB1', 'CDH2']]\n", + "Q05397 Q15942\n", + "Q15942 P12931\n", + "P12931 P19022\n", + "Q05397 P42224\n", + "P42224 O15105\n", + "O15105 P19022\n", + "Q05397 P42224\n", + "P42224 P00519\n", + "P00519 P19022\n", + "Q05397 P42224\n", + "P42224 P05412\n", + "P05412 P19022\n", + "Q05397 P42224\n", + "P42224 P01106\n", + "P01106 P19022\n", + "Q05397 P42224\n", + "P42224 COMPLEX:P19838_Q04206\n", + "COMPLEX:P19838_Q04206 P19022\n", + "Q05397 P42224\n", + "P42224 P19544\n", + "P19544 P19022\n", + "Q05397 P42224\n", + "P42224 P08581\n", + "P08581 P19022\n", + "Q05397 Q08043\n", + "Q08043 P12931\n", + "P12931 P19022\n", + "Q05397 P48736\n", + "P48736 P10275\n", + "P10275 P19022\n", + "Q05397 O75030\n", + "O75030 P08581\n", + "P08581 P19022\n", + "Q05397 O75030\n", + "O75030 P26367\n", + "P26367 P19022\n", + "Q05397 P05231\n", + "P05231 P08581\n", + "P08581 P19022\n", + "Q05397 P60953\n", + "P60953 O60716\n", + "O60716 P19022\n", + "Q05397 Q9ULH1\n", + "Q9ULH1 P10275\n", + "P10275 P19022\n", + "Q05397 P61224\n", + "P61224 O60716\n", + "O60716 P19022\n", + "Q05397 Q13485\n", + "Q13485 P28360\n", + "P28360 P19022\n", + "Q05397 Q13485\n", + "Q13485 P37231\n", + "P37231 P19022\n", + "Q05397 Q13485\n", + "Q13485 P01106\n", + "P01106 P19022\n", + "Q05397 Q13485\n", + "Q13485 O15105\n", + "O15105 P19022\n", + "Q05397 Q13485\n", + "Q13485 P48436\n", + "P48436 P19022\n", + "Q05397 Q13485\n", + "Q13485 P08581\n", + "P08581 P19022\n", + "Q05397 Q13485\n", + "Q13485 P08253\n", + "P08253 P19022\n", + "Q05397 P16144\n", + "P16144 P12931\n", + "P12931 P19022\n", + "Q05397 O43707\n", + "O43707 P12931\n", + "P12931 P19022\n", + "Q05397 Q12923\n", + "Q12923 P12931\n", + "P12931 P19022\n", + "Q05397 Q12923\n", + "Q12923 P08581\n", + "P08581 P19022\n", + "Q05397 P10599\n", + "P10599 P18031\n", + "P18031 P19022\n", + "Q05397 P53778\n", + "P53778 P05412\n", + "P05412 P19022\n", + "Q05397 P53778\n", + "P53778 P01106\n", + "P01106 P19022\n", + "Q05397 Q15788\n", + "Q15788 P12931\n", + "P12931 P19022\n", + "Q05397 Q15788\n", + "Q15788 P40763\n", + "P40763 P19022\n", + "Q05397 Q15788\n", + "Q15788 Q96IZ0\n", + "Q96IZ0 P19022\n", + "Q05397 Q15788\n", + "Q15788 P08253\n", + "P08253 P19022\n", + "Q13464 Q05397\n", + "P63000 Q13464\n", + "P19022 P63000\n", + "Q13464 Q05397\n", + "Q13464 P35222\n", + "P19022 P35222\n", + "P04198 Q05397\n", + "P35222 P04198\n", + "P19022 P35222\n", + "P49715 Q05397\n", + "P35222 P49715\n", + "P19022 P35222\n", + "Q05397 P42338\n", + "P27986 P42338\n", + "P19022 P27986\n", + "Q05397 P42338\n", + "P61586 P42338\n", + "P19022 P61586\n", + "P17655 Q05397\n", + "P35222 P17655\n", + "P19022 P35222\n", + "P29323 Q05397\n", + "P35222 P29323\n", + "P19022 P35222\n", + "Q05397 Q8WYR1\n", + "Q8WYR1 P63000\n", + "P19022 P63000\n", + "P55210 Q05397\n", + "P35222 P55210\n", + "P19022 P35222\n", + "Q00535 Q05397\n", + "P63000 Q00535\n", + "P19022 P63000\n", + "Q16610 Q05397\n", + "P63000 Q16610\n", + "P19022 P63000\n", + "Q16610 Q05397\n", + "P35222 Q16610\n", + "P19022 P35222\n", + "P35968 Q05397\n", + "P63000 P35968\n", + "P19022 P63000\n", + "Q07889 Q05397\n", + "Q07889 P42336\n", + "P19022 P42336\n", + "Q07889 Q05397\n", + "P61586 Q07889\n", + "P19022 P61586\n", + "P15692 Q05397\n", + "P15692 P63000\n", + "P19022 P63000\n", + "P15692 Q05397\n", + "P35222 P15692\n", + "P19022 P35222\n", + "P13612 Q05397\n", + "P61586 P13612\n", + "P19022 P61586\n", + "P00533 Q05397\n", + "P60953 P00533\n", + "P19022 P60953\n", + "P31431 Q05397\n", + "P14780 P31431\n", + "P19022 P14780\n", + "P16284 Q05397\n", + "P16591 P16284\n", + "P19022 P16591\n", + "Q03181 Q05397\n", + "P35222 Q03181\n", + "P19022 P35222\n", + "Q05397 P48736\n", + "P27986 P48736\n", + "P19022 P27986\n", + "P23443 Q05397\n", + "P23443 P27986\n", + "P19022 P27986\n", + "Q05397 Q92569\n", + "Q92569 P63000\n", + "P19022 P63000\n", + "P20827 Q05397\n", + "P35222 P20827\n", + "P19022 P35222\n", + "P42574 Q05397\n", + "P42574 P35222\n", + "P19022 P35222\n", + "Q05397 O00329\n", + "P27986 O00329\n", + "P19022 P27986\n", + "Q05397 O00329\n", + "O00329 P63000\n", + "P19022 P63000\n", + "P48061 Q05397\n", + "P35222 P48061\n", + "P19022 P35222\n", + "P12931 Q05397\n", + "P12830 P12931\n", + "P12931 P19022\n", + "P12931 Q14289\n", + "P02452 P12931\n", + "P12931 Q9NQB0\n", + "P12931 P19838\n", + "P12931 P41235\n", + "P41235 P12931\n", + "P12931 Q9H2X6\n", + "P12931 P42229\n", + "P12931 P54762\n", + "P54762 P12931\n", + "P12931 P37231\n", + "Q15942 P12931\n", + "P12931 P42224\n", + "P12931 P00519\n", + "P05412 P12931\n", + "COMPLEX:P19838_Q04206 P12931\n", + "P12931 P08581\n", + "Q08043 P12931\n", + "P12931 P10275\n", + "P10275 P12931\n", + "P12931 P60953\n", + "P12931 O60716\n", + "P12931 Q9ULH1\n", + "P12931 P08253\n", + "P12931 P16144\n", + "P16144 P12931\n", + "O43707 P12931\n", + "Q12923 P12931\n", + "P18031 P12931\n", + "Q15788 P12931\n", + "P12931 P40763\n", + "P12931 P63000\n", + "P12931 P35222\n", + "P12931 P42338\n", + "P12931 P61586\n", + "P17655 P12931\n", + "P29323 P12931\n", + "P12931 Q8WYR1\n", + "Q00535 P12931\n", + "P12931 P35968\n", + "P12931 Q07889\n", + "P12931 P42336\n", + "P15692 P12931\n", + "P13612 P12931\n", + "P12931 P00533\n", + "P12931 P14780\n", + "P12931 P16284\n", + "P12931 Q92569\n", + "P12931 P20827\n", + "P12931 O00329\n", + "P46531 P19022\n", + "P46531 P02452\n", + "P46531 P19838\n", + "P46531 P37231\n", + "P46531 P05412\n", + "P46531 P01106\n", + "COMPLEX:P19838_Q04206 P46531\n", + "P10275 P46531\n", + "P26367 P46531\n", + "P46531 P48436\n", + "P40763 P46531\n", + "P35222 P46531\n", + "P46531 P15692\n", + "P46531 P00533\n", + "P46531 P42574\n", + "Q14289 Q05397\n", + "P54762 Q05397\n", + "Q05397 Q15942\n", + "Q05397 P42224\n", + "COMPLEX:P19838_Q04206 Q05397\n", + "P08581 Q05397\n", + "Q05397 Q08043\n", + "Q05397 P48736\n", + "P48736 Q05397\n", + "Q05397 O75030\n", + "Q05397 P05231\n", + "Q05397 P60953\n", + "Q05397 Q9ULH1\n", + "Q05397 P61224\n", + "Q05397 Q13485\n", + "Q05397 P16144\n", + "P16144 Q05397\n", + "Q05397 O43707\n", + "Q05397 Q12923\n", + "Q05397 P10599\n", + "P18031 Q05397\n", + "Q05397 P53778\n", + "Q05397 Q15788\n", + "Q15788 Q05397\n", + "Q13464 Q05397\n", + "Q05397 P63000\n", + "P04198 Q05397\n", + "P49715 Q05397\n", + "Q05397 P42338\n", + "P42338 Q05397\n", + "Q05397 P27986\n", + "P61586 Q05397\n", + "P17655 Q05397\n", + "P29323 Q05397\n", + "Q05397 Q8WYR1\n", + "Q8WYR1 Q05397\n", + "P55210 Q05397\n", + "Q00535 Q05397\n", + "Q16610 Q05397\n", + "P35968 Q05397\n", + "Q07889 Q05397\n", + "Q05397 P42336\n", + "P15692 Q05397\n", + "P13612 Q05397\n", + "P00533 Q05397\n", + "P31431 Q05397\n", + "P16284 Q05397\n", + "Q03181 Q05397\n", + "P23443 Q05397\n", + "Q05397 Q92569\n", + "Q92569 Q05397\n", + "P20827 Q05397\n", + "P42574 Q05397\n", + "Q05397 O00329\n", + "O00329 Q05397\n", + "P48061 Q05397\n", + "P37231 P12830\n", + "P12830 Q15942\n", + "P05412 P12830\n", + "P01106 P12830\n", + "COMPLEX:P19838_Q04206 P12830\n", + "P19544 P12830\n", + "P08581 P12830\n", + "P10275 P12830\n", + "O75030 P12830\n", + "P60953 P12830\n", + "O60716 P12830\n", + "P61224 P12830\n", + "Q13485 P12830\n", + "P12830 P63000\n", + "P63000 P12830\n", + "P12830 P35222\n", + "P12830 P27986\n", + "P12830 P61586\n", + "P12830 P42336\n", + "P12830 P00533\n", + "P12830 P20827\n", + "P37231 P19022\n", + "O15105 P19022\n", + "P00519 P19022\n", + "P05412 P19022\n", + "P01106 P19022\n", + "COMPLEX:P19838_Q04206 P19022\n", + "P19544 P19022\n", + "P08581 P19022\n", + "P10275 P19022\n", + "P26367 P19022\n", + "P19022 P60953\n", + "O60716 P19022\n", + "P28360 P19022\n", + "P48436 P19022\n", + "P08253 P19022\n", + "P18031 P19022\n", + "P40763 P19022\n", + "Q96IZ0 P19022\n", + "P19022 P63000\n", + "P19022 P35222\n", + "P19022 P27986\n", + "P19022 P61586\n", + "Q00535 P19022\n", + "P19022 P42336\n", + "P19022 P14780\n", + "P19022 P16591\n", + "Q9NQB0 P08670\n", + "P19838 P08670\n", + "P41235 P08670\n", + "Q9H2X6 P08670\n", + "P42229 P08670\n", + "P05412 P08670\n", + "COMPLEX:P19838_Q04206 P08670\n", + "P40763 P08670\n", + "Q96IZ0 P08670\n", + "Q13464 P08670\n", + "P35222 P08670\n", + "P55210 P08670\n", + "P42574 P08670\n", + "P54762 O95819\n", + "P37231 O95819\n", + "P29323 O95819\n", + "Q14289 Q15942\n", + "P01106 Q14289\n", + "P48736 Q14289\n", + "Q14289 Q9ULH1\n", + "P61224 Q14289\n", + "Q14289 P10599\n", + "Q14289 P53778\n", + "Q14289 P40763\n", + "Q14289 P63000\n", + "P35968 Q14289\n", + "Q14289 Q07889\n", + "P42336 Q14289\n", + "P15692 Q14289\n", + "P13612 Q14289\n", + "Q14289 P00533\n", + "P19838 P02452\n", + "O15105 P02452\n", + "Q13485 P02452\n", + "P02452 P16144\n", + "P63000 P02452\n", + "P02452 P27986\n", + "P02452 P61586\n", + "P61586 P02452\n", + "P17655 P02452\n", + "P02452 P55210\n", + "P02452 Q07889\n", + "P02452 P42336\n", + "P02452 P13612\n", + "P02452 P31431\n", + "P02452 P42574\n", + "P41235 Q9NQB0\n", + "Q9NQB0 P05412\n", + "P05412 Q9NQB0\n", + "Q9NQB0 P01106\n", + "P10275 Q9NQB0\n", + "Q9NQB0 O75030\n", + "P26367 Q9NQB0\n", + "Q13485 Q9NQB0\n", + "Q9NQB0 P40763\n", + "Q9NQB0 P35222\n", + "P35222 Q9NQB0\n", + "Q9NQB0 P55210\n", + "Q9NQB0 P15692\n", + "Q9NQB0 Q03181\n", + "Q9NQB0 P42574\n", + "Q9NQB0 P48061\n", + "P19838 P42229\n", + "P37231 P19838\n", + "P19838 P05412\n", + "P19838 P01106\n", + "COMPLEX:P19838_Q04206 P19838\n", + "P19838 P19544\n", + "P19838 P10275\n", + "P19838 P05231\n", + "P19838 P08253\n", + "P19838 Q12923\n", + "P10599 P19838\n", + "P63000 P19838\n", + "P27986 P19838\n", + "P19838 P35968\n", + "P42336 P19838\n", + "P19838 P15692\n", + "P19838 P00533\n", + "P00533 P19838\n", + "P19838 P14780\n", + "P41235 P01106\n", + "COMPLEX:P19838_Q04206 P41235\n", + "P41235 P10275\n", + "P41235 P63000\n", + "P35222 P41235\n", + "P41235 P49715\n", + "P00519 Q9H2X6\n", + "Q9H2X6 P26367\n", + "P26367 Q9H2X6\n", + "Q9H2X6 P15692\n", + "P37231 P42229\n", + "P42229 P00519\n", + "P00519 P42229\n", + "P42229 P01106\n", + "COMPLEX:P19838_Q04206 P42229\n", + "P42229 P10275\n", + "P10275 P42229\n", + "P18031 P42229\n", + "Q15788 P42229\n", + "P42229 P49715\n", + "P00533 P42229\n", + "P16591 P42229\n", + "P42229 O00329\n", + "P48061 P42229\n", + "P26367 P54762\n", + "Q12923 P54762\n", + "P54762 P63000\n", + "P54762 P27986\n", + "P54762 P42336\n", + "P00519 P37231\n", + "P37231 P05412\n", + "P37231 P01106\n", + "COMPLEX:P19838_Q04206 P37231\n", + "Q13485 P37231\n", + "P37231 P08253\n", + "P37231 P40763\n", + "P37231 P35222\n", + "P35222 P37231\n", + "P49715 P37231\n", + "P37231 P35968\n", + "P37231 P00533\n", + "P37231 P14780\n", + "Q03181 P37231\n", + "P19544 Q15942\n", + "O60716 Q15942\n", + "P35222 Q15942\n", + "Q15942 P27986\n", + "Q15942 P61586\n", + "Q00535 Q15942\n", + "Q15942 P42336\n", + "P42224 O15105\n", + "P42224 P00519\n", + "P00519 P42224\n", + "P42224 P05412\n", + "P42224 P01106\n", + "P42224 COMPLEX:P19838_Q04206\n", + "P42224 P19544\n", + "P42224 P08581\n", + "P10275 P42224\n", + "P42224 P05231\n", + "P05231 P42224\n", + "P53778 P42224\n", + "P40763 P42224\n", + "P29323 P42224\n", + "P42224 P15692\n", + "P42224 P00533\n", + "P00533 P42224\n", + "P42224 P14780\n", + "P48061 P42224\n", + "P05412 O15105\n", + "P01106 O15105\n", + "COMPLEX:P19838_Q04206 O15105\n", + "O15105 P08581\n", + "O15105 P05231\n", + "Q13485 O15105\n", + "O15105 P08253\n", + "O15105 P35222\n", + "P35222 O15105\n", + "O15105 P15692\n", + "O15105 P14780\n", + "P00519 P05412\n", + "P05412 P00519\n", + "P01106 P00519\n", + "COMPLEX:P19838_Q04206 P00519\n", + "P00519 P08581\n", + "P00519 O60716\n", + "P18031 P00519\n", + "P00519 P40763\n", + "P00519 P63000\n", + "P00519 P35222\n", + "P00519 P29323\n", + "P00519 Q00535\n", + "P00519 Q07889\n", + "P00519 P00533\n", + "P00519 P48061\n", + "P05412 P01106\n", + "COMPLEX:P19838_Q04206 P05412\n", + "P05412 P08581\n", + "P10275 P05412\n", + "P05412 O75030\n", + "P05412 P05231\n", + "P05412 Q13485\n", + "P05412 P08253\n", + "P05412 P10599\n", + "P05412 P53778\n", + "P53778 P05412\n", + "P05412 P63000\n", + "P05412 P35222\n", + "P35222 P05412\n", + "P49715 P05412\n", + "P05412 P27986\n", + "P05412 P29323\n", + "P05412 P15692\n", + "P05412 P00533\n", + "P05412 P14780\n", + "P05412 Q03181\n", + "P05412 P42574\n", + "P05412 P48061\n", + "COMPLEX:P19838_Q04206 P01106\n", + "P19544 P01106\n", + "P01106 P08581\n", + "Q13485 P01106\n", + "P01106 P48436\n", + "P01106 P08253\n", + "P01106 P16144\n", + "P01106 P10599\n", + "P53778 P01106\n", + "P40763 P01106\n", + "P63000 P01106\n", + "P35222 P01106\n", + "P01106 P04198\n", + "P04198 P01106\n", + "P01106 P49715\n", + "P49715 P01106\n", + "P01106 P27986\n", + "P27986 P01106\n", + "P01106 P61586\n", + "P01106 P29323\n", + "P01106 Q00535\n", + "P42336 P01106\n", + "P01106 P15692\n", + "P01106 P13612\n", + "P01106 P14780\n", + "P23443 P01106\n", + "P01106 O00329\n", + "P01106 P48061\n", + "COMPLEX:P19838_Q04206 P19544\n", + "COMPLEX:P19838_Q04206 P08581\n", + "COMPLEX:P19838_Q04206 P10275\n", + "COMPLEX:P19838_Q04206 P05231\n", + "COMPLEX:P19838_Q04206 P60953\n", + "COMPLEX:P19838_Q04206 P28360\n", + "COMPLEX:P19838_Q04206 P48436\n", + "COMPLEX:P19838_Q04206 P08253\n", + "COMPLEX:P19838_Q04206 Q12923\n", + "COMPLEX:P19838_Q04206 P18031\n", + "COMPLEX:P19838_Q04206 Q13464\n", + "COMPLEX:P19838_Q04206 P35222\n", + "COMPLEX:P19838_Q04206 P49715\n", + "COMPLEX:P19838_Q04206 P27986\n", + "COMPLEX:P19838_Q04206 P29323\n", + "COMPLEX:P19838_Q04206 P55210\n", + "COMPLEX:P19838_Q04206 P35968\n", + "COMPLEX:P19838_Q04206 P42336\n", + "COMPLEX:P19838_Q04206 P15692\n", + "COMPLEX:P19838_Q04206 P00533\n", + "COMPLEX:P19838_Q04206 P31431\n", + "COMPLEX:P19838_Q04206 P14780\n", + "COMPLEX:P19838_Q04206 P16284\n", + "COMPLEX:P19838_Q04206 P48061\n", + "P19544 P10275\n", + "Q96IZ0 P19544\n", + "P19544 P04198\n", + "P19544 P13612\n", + "P19544 P00533\n", + "P19544 P14780\n", + "Q03181 P19544\n", + "P08581 P48736\n", + "P10275 P08581\n", + "O75030 P08581\n", + "P26367 P08581\n", + "P05231 P08581\n", + "P08581 P60953\n", + "P08581 O60716\n", + "Q13485 P08581\n", + "Q12923 P08581\n", + "P18031 P08581\n", + "P08581 P40763\n", + "P08581 P35222\n", + "P08581 P42338\n", + "P08581 P27986\n", + "P08581 Q8WYR1\n", + "P08581 P42336\n", + "P15692 P08581\n", + "P08581 P23443\n", + "P08581 Q92569\n", + "P08581 O00329\n", + "P63000 Q08043\n", + "Q08043 P27986\n", + "Q08043 P61586\n", + "P61586 Q08043\n", + "Q08043 P42336\n", + "P48736 P10275\n", + "P16144 P48736\n", + "P48736 P63000\n", + "P27986 P48736\n", + "P35968 P48736\n", + "P00533 P48736\n", + "P48061 P48736\n", + "P26367 P10275\n", + "P10275 P05231\n", + "P10275 P60953\n", + "P10275 Q9ULH1\n", + "Q9ULH1 P10275\n", + "Q13485 P10275\n", + "P10275 P08253\n", + "P10275 P10599\n", + "P10275 P18031\n", + "Q15788 P10275\n", + "P10275 P35222\n", + "P10275 P42338\n", + "P10275 P27986\n", + "P55210 P10275\n", + "P10275 Q00535\n", + "Q00535 P10275\n", + "P10275 P15692\n", + "P10275 P00533\n", + "P16591 P10275\n", + "P10275 P20827\n", + "P42574 P10275\n", + "O75030 P26367\n", + "P26367 O75030\n", + "P05231 O75030\n", + "P48436 O75030\n", + "P35222 O75030\n", + "O75030 P15692\n", + "O75030 P13612\n", + "P26367 O60716\n", + "P26367 P08253\n", + "P26367 P15692\n", + "P26367 P13612\n", + "P26367 P14780\n", + "Q15788 P05231\n", + "P05231 P40763\n", + "P35222 P05231\n", + "P04198 P05231\n", + "P49715 P05231\n", + "P05231 P35968\n", + "P05231 Q07889\n", + "P05231 P15692\n", + "P15692 P05231\n", + "P05231 P14780\n", + "Q03181 P05231\n", + "P05231 P48061\n", + "P60953 O60716\n", + "P61224 P60953\n", + "P60953 P53778\n", + "P60953 P35222\n", + "P35222 P60953\n", + "P04198 P60953\n", + "P60953 P27986\n", + "P27986 P60953\n", + "P29323 P60953\n", + "P35968 P60953\n", + "P42336 P60953\n", + "P15692 P60953\n", + "P60953 P00533\n", + "P60953 P23443\n", + "P48061 P60953\n", + "P61224 O60716\n", + "P18031 O60716\n", + "O60716 P63000\n", + "O60716 P27986\n", + "O60716 P61586\n", + "O60716 P42336\n", + "P00533 O60716\n", + "P16591 O60716\n", + "O60716 P20827\n", + "Q9ULH1 P63000\n", + "Q9ULH1 P61586\n", + "P61224 P63000\n", + "P61224 P35222\n", + "P61224 P27986\n", + "P61224 P61586\n", + "P61224 P42336\n", + "P61224 P13612\n", + "Q13485 P28360\n", + "Q13485 P48436\n", + "Q13485 P08253\n", + "Q15788 Q13485\n", + "Q13485 P04198\n", + "Q00535 Q13485\n", + "Q13485 P15692\n", + "Q13485 P00533\n", + "Q13485 Q03181\n", + "Q13485 P48061\n", + "P35222 P28360\n", + "Q13464 P48436\n", + "P48436 P35222\n", + "P48436 P42336\n", + "P48436 P15692\n", + "Q15788 P08253\n", + "P63000 P08253\n", + "P35222 P08253\n", + "P04198 P08253\n", + "P08253 P00533\n", + "P16144 P42338\n", + "P16144 P27986\n", + "P17655 P16144\n", + "P55210 P16144\n", + "P16144 P42336\n", + "P42574 P16144\n", + "P16144 O00329\n", + "P63000 O43707\n", + "O43707 P27986\n", + "O43707 P61586\n", + "P61586 O43707\n", + "O43707 P42336\n", + "P40763 Q12923\n", + "Q12923 P29323\n", + "P10599 P18031\n", + "P18031 P40763\n", + "P18031 P35222\n", + "P18031 P27986\n", + "P61586 P18031\n", + "P17655 P18031\n", + "P18031 P42336\n", + "P00533 P18031\n", + "P16591 P18031\n", + "P53778 P49715\n", + "Q00535 P53778\n", + "Q15788 P40763\n", + "Q15788 Q96IZ0\n", + "Q15788 P15692\n", + "Q15788 P00533\n", + "P63000 P40763\n", + "P40763 P35222\n", + "P49715 P40763\n", + "P40763 P27986\n", + "P27986 P40763\n", + "Q00535 P40763\n", + "P42336 P40763\n", + "P40763 P15692\n", + "P00533 P40763\n", + "P40763 P14780\n", + "P16591 P40763\n", + "P40763 P42574\n", + "P40763 P48061\n", + "P48061 P40763\n", + "P63000 Q13464\n", + "Q13464 P35222\n", + "P35222 Q13464\n", + "P61586 Q13464\n", + "P42574 Q13464\n", + "P48061 Q13464\n", + "P63000 P35222\n", + "P63000 P42338\n", + "P27986 P63000\n", + "P63000 P61586\n", + "P29323 P63000\n", + "P63000 Q8WYR1\n", + "Q8WYR1 P63000\n", + "P63000 Q00535\n", + "P63000 Q16610\n", + "P63000 P35968\n", + "Q07889 P63000\n", + "P63000 P42336\n", + "P42336 P63000\n", + "P63000 P15692\n", + "P15692 P63000\n", + "P13612 P63000\n", + "P00533 P63000\n", + "P31431 P63000\n", + "P63000 Q92569\n", + "Q92569 P63000\n", + "P20827 P63000\n", + "P63000 O00329\n", + "O00329 P63000\n", + "P48061 P63000\n", + "P35222 P04198\n", + "P35222 P49715\n", + "P35222 P27986\n", + "P35222 P61586\n", + "P35222 P17655\n", + "P35222 P29323\n", + "P35222 P55210\n", + "P35222 Q16610\n", + "P35222 P42336\n", + "P35222 P15692\n", + "P00533 P35222\n", + "P35222 P14780\n", + "P16591 P35222\n", + "P35222 Q03181\n", + "P35222 P20827\n", + "P35222 P42574\n", + "P42574 P35222\n", + "P35222 P48061\n", + "P04198 P00533\n", + "Q03181 P49715\n", + "P27986 P42338\n", + "P61586 P42338\n", + "P35968 P42338\n", + "P42338 Q07889\n", + "P00533 P42338\n", + "Q92569 P42338\n", + "P48061 P42338\n", + "P27986 P61586\n", + "P61586 P27986\n", + "P29323 P27986\n", + "P35968 P27986\n", + "P27986 Q07889\n", + "P15692 P27986\n", + "P00533 P27986\n", + "P27986 P23443\n", + "P23443 P27986\n", + "P27986 O00329\n", + "P48061 P27986\n", + "P17655 P61586\n", + "P61586 Q07889\n", + "P61586 P42336\n", + "P42336 P61586\n", + "P61586 P13612\n", + "P00533 P61586\n", + "P61586 P14780\n", + "P20827 P61586\n", + "P42574 P61586\n", + "P29323 P42336\n", + "P48061 P29323\n", + "P35968 Q8WYR1\n", + "P00533 Q8WYR1\n", + "P48061 Q8WYR1\n", + "P42574 P55210\n", + "P35968 Q07889\n", + "P35968 P42336\n", + "P15692 P35968\n", + "P35968 P16284\n", + "P35968 Q92569\n", + "P35968 O00329\n", + "Q07889 P42336\n", + "P42336 Q07889\n", + "P15692 Q07889\n", + "P00533 Q07889\n", + "Q92569 Q07889\n", + "O00329 Q07889\n", + "P15692 P42336\n", + "P00533 P42336\n", + "P42336 P23443\n", + "Q92569 P42336\n", + "P48061 P42336\n", + "P15692 P00533\n", + "P15692 P14780\n", + "P00533 P14780\n", + "P00533 Q92569\n", + "P00533 O00329\n", + "P14780 P31431\n", + "Q03181 P14780\n", + "P23443 P14780\n", + "P48061 P14780\n", + "P16591 P16284\n", + "P48061 Q92569\n", + "P48061 O00329\n", + "looking for paths in the network with length: 0 for node PTK2 and VIM\n", + "looking for paths in the network with length: 1 for node PTK2 and VIM\n", + "looking for paths in the network with length: 2 for node PTK2 and VIM\n", + "looking for paths in the network with length: 3 for node PTK2 and VIM\n", + "Found a path!\n", + "[['PTK2', 'MAPK12', 'JUN', 'VIM'], ['PTK2', 'PIK3R1', 'STAT3', 'VIM'], ['PTK2', 'PIK3R1', 'NFKB1', 'VIM'], ['PTK2', 'IL6', 'STAT3', 'VIM'], ['PTK2', 'CDC42', 'CTNNB1', 'VIM'], ['PTK2', 'NCOA1', 'STAT5A', 'VIM'], ['PTK2', 'NCOA1', 'STAT3', 'VIM'], ['PTK2', 'NCOA1', 'PAWR', 'VIM'], ['PTK2', 'RAC1', 'ROCK1', 'VIM'], ['PTK2', 'RAC1', 'NFKB1', 'VIM'], ['PTK2', 'RAC1', 'STAT3', 'VIM'], ['PTK2', 'RAC1', 'CTNNB1', 'VIM'], ['PTK2', 'RAP1B', 'CTNNB1', 'VIM'], ['PTK2', 'SMAD4', 'TCF7L2', 'VIM'], ['PTK2', 'PIK3CA', 'STAT3', 'VIM'], ['PTK2', 'PIK3CA', 'NFKB1', 'VIM'], ['PTK2', 'STAT1', 'JUN', 'VIM'], ['PTK2', 'STAT1', 'COMPLEX:P19838_Q04206', 'VIM'], ['PTK2', 'TXN', 'NFKB1', 'VIM']]\n", + "looking for paths in the network with length: 0 for node PTK2 and MAP4K4\n", + "looking for paths in the network with length: 1 for node PTK2 and MAP4K4\n", + "looking for paths in the network with length: 2 for node PTK2 and MAP4K4\n", + "looking for paths in the network with length: 3 for node PTK2 and MAP4K4\n", + "Found a path!\n", + "[['PTK2', 'PTPN13', 'EPHB1', 'MAP4K4'], ['PTK2', 'PTPN13', 'EPHB2', 'MAP4K4'], ['PTK2', 'SMAD4', 'PPARG', 'MAP4K4']]\n", + "looking for paths in the network with length: 0 for node PTK2 and PTK2B\n", + "looking for paths in the network with length: 1 for node PTK2 and PTK2B\n", + "Found a path!\n", + "[['PTK2', 'PTK2B']]\n", + "looking for paths in the network with length: 0 for node PTK2 and COL1A1\n", + "looking for paths in the network with length: 1 for node PTK2 and COL1A1\n", + "looking for paths in the network with length: 2 for node PTK2 and COL1A1\n", + "Found a path!\n", + "[['PTK2', 'RAC1', 'COL1A1'], ['PTK2', 'SMAD4', 'COL1A1'], ['PTK2', 'SRC', 'COL1A1'], ['PTK2', 'CASP7', 'COL1A1'], ['PTK2', 'RHOA', 'COL1A1'], ['PTK2', 'ITGA4', 'COL1A1'], ['PTK2', 'SDC4', 'COL1A1'], ['PTK2', 'ITGB4', 'COL1A1'], ['PTK2', 'CASP3', 'COL1A1'], ['PTK2', 'SOS1', 'COL1A1']]\n", + "looking for paths in the network with length: 0 for node CDH1 and CDH2\n", + "looking for paths in the network with length: 1 for node CDH1 and CDH2\n", + "looking for paths in the network with length: 2 for node CDH1 and CDH2\n", + "Found a path!\n", + "[['CDH1', 'SRC', 'CDH2'], ['CDH1', 'RAC1', 'CDH2'], ['CDH1', 'CDC42', 'CDH2']]\n", + "looking for paths in the network with length: 0 for node CDH1 and VIM\n", + "looking for paths in the network with length: 1 for node CDH1 and VIM\n", + "looking for paths in the network with length: 2 for node CDH1 and VIM\n", + "Found a path!\n", + "[['CDH1', 'CTNNB1', 'VIM']]\n", + "looking for paths in the network with length: 0 for node CDH1 and MAP4K4\n", + "looking for paths in the network with length: 1 for node CDH1 and MAP4K4\n", + "looking for paths in the network with length: 2 for node CDH1 and MAP4K4\n", + "looking for paths in the network with length: 3 for node CDH1 and MAP4K4\n", + "Found a path!\n", + "[['CDH1', 'SRC', 'EPHB1', 'MAP4K4'], ['CDH1', 'SRC', 'PPARG', 'MAP4K4'], ['CDH1', 'CTNNB1', 'EPHB2', 'MAP4K4'], ['CDH1', 'CTNNB1', 'PPARG', 'MAP4K4']]\n", + "looking for paths in the network with length: 0 for node CDH1 and PTK2B\n", + "looking for paths in the network with length: 1 for node CDH1 and PTK2B\n", + "looking for paths in the network with length: 2 for node CDH1 and PTK2B\n", + "Found a path!\n", + "[['CDH1', 'SRC', 'PTK2B'], ['CDH1', 'PIK3CA', 'PTK2B'], ['CDH1', 'RAC1', 'PTK2B']]\n", + "looking for paths in the network with length: 0 for node CDH1 and COL1A1\n", + "looking for paths in the network with length: 1 for node CDH1 and COL1A1\n", + "looking for paths in the network with length: 2 for node CDH1 and COL1A1\n", + "Found a path!\n", + "[['CDH1', 'RAC1', 'COL1A1'], ['CDH1', 'RHOA', 'COL1A1']]\n", + "looking for paths in the network with length: 0 for node CDH2 and VIM\n", + "looking for paths in the network with length: 1 for node CDH2 and VIM\n", + "looking for paths in the network with length: 2 for node CDH2 and VIM\n", + "Found a path!\n", + "[['CDH2', 'CTNNB1', 'VIM']]\n", + "looking for paths in the network with length: 0 for node CDH2 and MAP4K4\n", + "looking for paths in the network with length: 1 for node CDH2 and MAP4K4\n", + "looking for paths in the network with length: 2 for node CDH2 and MAP4K4\n", + "looking for paths in the network with length: 3 for node CDH2 and MAP4K4\n", + "Found a path!\n", + "[['CDH2', 'CTNNB1', 'EPHB2', 'MAP4K4'], ['CDH2', 'CTNNB1', 'PPARG', 'MAP4K4']]\n", + "looking for paths in the network with length: 0 for node CDH2 and PTK2B\n", + "looking for paths in the network with length: 1 for node CDH2 and PTK2B\n", + "looking for paths in the network with length: 2 for node CDH2 and PTK2B\n", + "Found a path!\n", + "[['CDH2', 'PIK3CA', 'PTK2B'], ['CDH2', 'STAT3', 'PTK2B']]\n", + "looking for paths in the network with length: 0 for node CDH2 and COL1A1\n", + "looking for paths in the network with length: 1 for node CDH2 and COL1A1\n", + "looking for paths in the network with length: 2 for node CDH2 and COL1A1\n", + "Found a path!\n", + "[['CDH2', 'RAC1', 'COL1A1'], ['CDH2', 'RHOA', 'COL1A1'], ['CDH2', 'SRC', 'COL1A1']]\n", + "looking for paths in the network with length: 0 for node VIM and MAP4K4\n", + "looking for paths in the network with length: 1 for node VIM and MAP4K4\n", + "looking for paths in the network with length: 2 for node VIM and MAP4K4\n", + "looking for paths in the network with length: 3 for node VIM and MAP4K4\n", + "i_search = 3\n", + "Looking for paths with length: 0 for node VIM and MAP4K4\n", + "i_search = 3\n", + "Looking for paths with length: 1 for node VIM and MAP4K4\n", + "i_search = 3\n", + "Looking for paths with length: 2 for node VIM and MAP4K4\n", + "i_search = 3\n", + "Looking for paths with length: 3 for node VIM and MAP4K4\n", + "[['VIM', 'TGFB1', 'TNF', 'MAP4K4'], ['VIM', 'COMPLEX:P19838_Q04206', 'IKBKB', 'MAP4K4'], ['VIM', 'COMPLEX:P19838_Q04206', 'IKBKE', 'MAP4K4'], ['VIM', 'COMPLEX:P19838_Q04206', 'IKBKG', 'MAP4K4'], ['VIM', 'COMPLEX:P19838_Q04206', 'CHUK', 'MAP4K4'], ['VIM', 'TP63', 'IKBKB', 'MAP4K4'], ['VIM', 'AKT1', 'TNF', 'MAP4K4'], ['VIM', 'COMPLEX:Q04206_Q04864', 'IKBKE', 'MAP4K4'], ['VIM', 'COMPLEX:Q00653_Q01201', 'CHUK', 'MAP4K4'], ['VIM', 'MAPKAPK2', 'TNF', 'MAP4K4'], ['VIM', 'JUN', 'MAP3K3', 'MAP4K4'], ['VIM', 'CASP3', 'TNF', 'MAP4K4'], ['VIM', 'PLK1', 'MAP3K8', 'MAP4K4'], ['VIM', 'IRF6', 'TNF', 'MAP4K4'], ['VIM', 'NFKB1', 'IKBKG', 'MAP4K4'], ['VIM', 'NFKB1', 'MAP3K2', 'MAP4K4'], ['VIM', 'NFKB1', 'IKBKE', 'MAP4K4'], ['VIM', 'NFKB1', 'MAP3K3', 'MAP4K4']]\n", + "P01137 P08670\n", + "P01375 P01137\n", + "P01375 O95819\n", + "COMPLEX:P19838_Q04206 P08670\n", + "O14920 COMPLEX:P19838_Q04206\n", + "O95819 O14920\n", + "COMPLEX:P19838_Q04206 P08670\n", + "COMPLEX:P19838_Q04206 Q14164\n", + "O95819 Q14164\n", + "COMPLEX:P19838_Q04206 P08670\n", + "Q9Y6K9 COMPLEX:P19838_Q04206\n", + "O95819 Q9Y6K9\n", + "COMPLEX:P19838_Q04206 P08670\n", + "O15111 COMPLEX:P19838_Q04206\n", + "O95819 O15111\n", + "Q9H3D4 P08670\n", + "O14920 Q9H3D4\n", + "O95819 O14920\n", + "P31749 P08670\n", + "P01375 P31749\n", + "P01375 O95819\n", + "COMPLEX:Q04206_Q04864 P08670\n", + "COMPLEX:Q04206_Q04864 Q14164\n", + "O95819 Q14164\n", + "COMPLEX:Q00653_Q01201 P08670\n", + "O15111 COMPLEX:Q00653_Q01201\n", + "O95819 O15111\n", + "P49137 P08670\n", + "P01375 P49137\n", + "P01375 O95819\n", + "P05412 P08670\n", + "Q99759 P05412\n", + "O95819 Q99759\n", + "P42574 P08670\n", + "P01375 P42574\n", + "P01375 O95819\n", + "P53350 P08670\n", + "P41279 P53350\n", + "O95819 P41279\n", + "O14896 P08670\n", + "O14896 P01375\n", + "P01375 O95819\n", + "P19838 P08670\n", + "P19838 Q9Y6K9\n", + "O95819 Q9Y6K9\n", + "P19838 P08670\n", + "Q9Y2U5 P19838\n", + "O95819 Q9Y2U5\n", + "P19838 P08670\n", + "Q14164 P19838\n", + "O95819 Q14164\n", + "P19838 P08670\n", + "Q99759 P19838\n", + "O95819 Q99759\n", + "P12931 Q05397\n", + "P12830 P12931\n", + "P12931 P19022\n", + "P12931 Q14289\n", + "P02452 P12931\n", + "P12931 Q9NQB0\n", + "P12931 P19838\n", + "P12931 P41235\n", + "P41235 P12931\n", + "P12931 Q9H2X6\n", + "P12931 P42229\n", + "P12931 P54762\n", + "P54762 P12931\n", + "P12931 P37231\n", + "Q15942 P12931\n", + "P12931 P42224\n", + "P12931 P00519\n", + "P05412 P12931\n", + "COMPLEX:P19838_Q04206 P12931\n", + "P12931 P08581\n", + "Q08043 P12931\n", + "P12931 P10275\n", + "P10275 P12931\n", + "P12931 P60953\n", + "P12931 O60716\n", + "P12931 Q9ULH1\n", + "P12931 P08253\n", + "P12931 P16144\n", + "P16144 P12931\n", + "O43707 P12931\n", + "Q12923 P12931\n", + "P18031 P12931\n", + "Q15788 P12931\n", + "P12931 P40763\n", + "P12931 P63000\n", + "P12931 P35222\n", + "P12931 P42338\n", + "P12931 P61586\n", + "P17655 P12931\n", + "P29323 P12931\n", + "P12931 Q8WYR1\n", + "Q00535 P12931\n", + "P12931 P35968\n", + "P12931 Q07889\n", + "P12931 P42336\n", + "P15692 P12931\n", + "P13612 P12931\n", + "P12931 P00533\n", + "P12931 P14780\n", + "P12931 P16284\n", + "P12931 Q92569\n", + "P12931 P20827\n", + "P12931 O00329\n", + "P12931 O14920\n", + "P12931 O15111\n", + "P12931 P31749\n", + "COMPLEX:Q04206_Q04864 P12931\n", + "COMPLEX:Q00653_Q01201 P12931\n", + "P12931 Q9Y2U5\n", + "P46531 P19022\n", + "P46531 P02452\n", + "P46531 P19838\n", + "P46531 P37231\n", + "P46531 P05412\n", + "P46531 P01106\n", + "COMPLEX:P19838_Q04206 P46531\n", + "P10275 P46531\n", + "P26367 P46531\n", + "P46531 P48436\n", + "P40763 P46531\n", + "P35222 P46531\n", + "P46531 P15692\n", + "P46531 P00533\n", + "P46531 P42574\n", + "P46531 O15111\n", + "Q9H3D4 P46531\n", + "COMPLEX:Q04206_Q04864 P46531\n", + "COMPLEX:Q00653_Q01201 P46531\n", + "Q14289 Q05397\n", + "P54762 Q05397\n", + "Q05397 Q15942\n", + "Q05397 P42224\n", + "COMPLEX:P19838_Q04206 Q05397\n", + "P08581 Q05397\n", + "Q05397 Q08043\n", + "Q05397 P48736\n", + "P48736 Q05397\n", + "Q05397 O75030\n", + "Q05397 P05231\n", + "Q05397 P60953\n", + "Q05397 Q9ULH1\n", + "Q05397 P61224\n", + "Q05397 Q13485\n", + "Q05397 P16144\n", + "P16144 Q05397\n", + "Q05397 O43707\n", + "Q05397 Q12923\n", + "Q05397 P10599\n", + "P18031 Q05397\n", + "Q05397 P53778\n", + "Q05397 Q15788\n", + "Q15788 Q05397\n", + "Q13464 Q05397\n", + "Q05397 P63000\n", + "P04198 Q05397\n", + "P49715 Q05397\n", + "Q05397 P42338\n", + "P42338 Q05397\n", + "Q05397 P27986\n", + "P61586 Q05397\n", + "P17655 Q05397\n", + "P29323 Q05397\n", + "Q05397 Q8WYR1\n", + "Q8WYR1 Q05397\n", + "P55210 Q05397\n", + "Q00535 Q05397\n", + "Q16610 Q05397\n", + "P35968 Q05397\n", + "Q07889 Q05397\n", + "Q05397 P42336\n", + "P15692 Q05397\n", + "P13612 Q05397\n", + "P00533 Q05397\n", + "P31431 Q05397\n", + "P16284 Q05397\n", + "Q03181 Q05397\n", + "P23443 Q05397\n", + "Q05397 Q92569\n", + "Q92569 Q05397\n", + "P20827 Q05397\n", + "P42574 Q05397\n", + "Q05397 O00329\n", + "O00329 Q05397\n", + "P48061 Q05397\n", + "P01375 Q05397\n", + "COMPLEX:Q04206_Q04864 Q05397\n", + "COMPLEX:Q00653_Q01201 Q05397\n", + "P37231 P12830\n", + "P12830 Q15942\n", + "P05412 P12830\n", + "P01106 P12830\n", + "COMPLEX:P19838_Q04206 P12830\n", + "P19544 P12830\n", + "P08581 P12830\n", + "P10275 P12830\n", + "O75030 P12830\n", + "P60953 P12830\n", + "O60716 P12830\n", + "P61224 P12830\n", + "Q13485 P12830\n", + "P12830 P63000\n", + "P63000 P12830\n", + "P12830 P35222\n", + "P12830 P27986\n", + "P12830 P61586\n", + "P12830 P42336\n", + "P12830 P00533\n", + "P12830 P20827\n", + "Q9H3D4 P12830\n", + "COMPLEX:Q04206_Q04864 P12830\n", + "COMPLEX:Q00653_Q01201 P12830\n", + "P37231 P19022\n", + "O15105 P19022\n", + "P00519 P19022\n", + "P05412 P19022\n", + "P01106 P19022\n", + "COMPLEX:P19838_Q04206 P19022\n", + "P19544 P19022\n", + "P08581 P19022\n", + "P10275 P19022\n", + "P26367 P19022\n", + "P19022 P60953\n", + "O60716 P19022\n", + "P28360 P19022\n", + "P48436 P19022\n", + "P08253 P19022\n", + "P18031 P19022\n", + "P40763 P19022\n", + "Q96IZ0 P19022\n", + "P19022 P63000\n", + "P19022 P35222\n", + "P19022 P27986\n", + "P19022 P61586\n", + "Q00535 P19022\n", + "P19022 P42336\n", + "P19022 P14780\n", + "P19022 P16591\n", + "COMPLEX:Q04206_Q04864 P19022\n", + "COMPLEX:Q00653_Q01201 P19022\n", + "Q9NQB0 P08670\n", + "P19838 P08670\n", + "P41235 P08670\n", + "Q9H2X6 P08670\n", + "P42229 P08670\n", + "P05412 P08670\n", + "COMPLEX:P19838_Q04206 P08670\n", + "P40763 P08670\n", + "Q96IZ0 P08670\n", + "Q13464 P08670\n", + "P35222 P08670\n", + "P55210 P08670\n", + "P42574 P08670\n", + "P01137 P08670\n", + "Q9H3D4 P08670\n", + "P31749 P08670\n", + "COMPLEX:Q04206_Q04864 P08670\n", + "COMPLEX:Q00653_Q01201 P08670\n", + "P49137 P08670\n", + "P53350 P08670\n", + "O14896 P08670\n", + "P54762 O95819\n", + "P37231 O95819\n", + "P29323 O95819\n", + "O95819 P01375\n", + "P01375 O95819\n", + "O95819 O14920\n", + "O95819 Q14164\n", + "O95819 Q9Y6K9\n", + "O95819 O15111\n", + "O95819 Q99759\n", + "O95819 P41279\n", + "O95819 Q9Y2U5\n", + "Q14289 Q15942\n", + "P01106 Q14289\n", + "P48736 Q14289\n", + "Q14289 Q9ULH1\n", + "P61224 Q14289\n", + "Q14289 P10599\n", + "Q14289 P53778\n", + "Q14289 P40763\n", + "Q14289 P63000\n", + "P35968 Q14289\n", + "Q14289 Q07889\n", + "P42336 Q14289\n", + "P15692 Q14289\n", + "P13612 Q14289\n", + "Q14289 P00533\n", + "P19838 P02452\n", + "O15105 P02452\n", + "Q13485 P02452\n", + "P02452 P16144\n", + "P63000 P02452\n", + "P02452 P27986\n", + "P02452 P61586\n", + "P61586 P02452\n", + "P17655 P02452\n", + "P02452 P55210\n", + "P02452 Q07889\n", + "P02452 P42336\n", + "P02452 P13612\n", + "P02452 P31431\n", + "P02452 P42574\n", + "P01137 P02452\n", + "P41235 Q9NQB0\n", + "Q9NQB0 P05412\n", + "P05412 Q9NQB0\n", + "Q9NQB0 P01106\n", + "P10275 Q9NQB0\n", + "Q9NQB0 O75030\n", + "P26367 Q9NQB0\n", + "Q13485 Q9NQB0\n", + "Q9NQB0 P40763\n", + "Q9NQB0 P35222\n", + "P35222 Q9NQB0\n", + "Q9NQB0 P55210\n", + "Q9NQB0 P15692\n", + "Q9NQB0 Q03181\n", + "Q9NQB0 P42574\n", + "Q9NQB0 P48061\n", + "P19838 P42229\n", + "P37231 P19838\n", + "P19838 P05412\n", + "P19838 P01106\n", + "COMPLEX:P19838_Q04206 P19838\n", + "P19838 P19544\n", + "P19838 P10275\n", + "P19838 P05231\n", + "P19838 P08253\n", + "P19838 Q12923\n", + "P10599 P19838\n", + "P63000 P19838\n", + "P27986 P19838\n", + "P19838 P35968\n", + "P42336 P19838\n", + "P19838 P15692\n", + "P19838 P00533\n", + "P00533 P19838\n", + "P19838 P14780\n", + "P19838 P01137\n", + "P01375 P19838\n", + "O14920 P19838\n", + "Q14164 P19838\n", + "P19838 Q9Y6K9\n", + "Q9Y6K9 P19838\n", + "O15111 P19838\n", + "P19838 P31749\n", + "P31749 P19838\n", + "COMPLEX:Q04206_Q04864 P19838\n", + "COMPLEX:Q00653_Q01201 P19838\n", + "Q99759 P19838\n", + "P19838 P41279\n", + "Q9Y2U5 P19838\n", + "P41235 P01106\n", + "COMPLEX:P19838_Q04206 P41235\n", + "P41235 P10275\n", + "P41235 P63000\n", + "P35222 P41235\n", + "P41235 P49715\n", + "P41235 P01375\n", + "COMPLEX:Q04206_Q04864 P41235\n", + "COMPLEX:Q00653_Q01201 P41235\n", + "P00519 Q9H2X6\n", + "Q9H2X6 P26367\n", + "P26367 Q9H2X6\n", + "Q9H2X6 P15692\n", + "P37231 P42229\n", + "P42229 P00519\n", + "P00519 P42229\n", + "P42229 P01106\n", + "COMPLEX:P19838_Q04206 P42229\n", + "P42229 P10275\n", + 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P35968\n", + "P35968 P16284\n", + "P35968 Q92569\n", + "P35968 O00329\n", + "P35968 P31749\n", + "COMPLEX:Q04206_Q04864 P35968\n", + "COMPLEX:Q00653_Q01201 P35968\n", + "Q07889 P42336\n", + "P42336 Q07889\n", + "P15692 Q07889\n", + "P00533 Q07889\n", + "Q92569 Q07889\n", + "O00329 Q07889\n", + "Q07889 P31749\n", + "P15692 P42336\n", + "P00533 P42336\n", + "P42336 P23443\n", + "Q92569 P42336\n", + "P48061 P42336\n", + "P01137 P42336\n", + "P42336 P31749\n", + "COMPLEX:Q04206_Q04864 P42336\n", + "COMPLEX:Q00653_Q01201 P42336\n", + "P15692 P00533\n", + "P15692 P14780\n", + "P01137 P15692\n", + "Q9H3D4 P15692\n", + "COMPLEX:Q04206_Q04864 P15692\n", + "COMPLEX:Q00653_Q01201 P15692\n", + "P49137 P15692\n", + "P00533 P14780\n", + "P00533 Q92569\n", + "P00533 O00329\n", + "P01137 P00533\n", + "COMPLEX:Q04206_Q04864 P00533\n", + "COMPLEX:Q00653_Q01201 P00533\n", + "P14780 P31431\n", + "COMPLEX:Q04206_Q04864 P31431\n", + "COMPLEX:Q00653_Q01201 P31431\n", + "Q03181 P14780\n", + "P23443 P14780\n", + "P48061 P14780\n", + "P14780 P01137\n", + "P01375 P14780\n", + "COMPLEX:Q04206_Q04864 P14780\n", + "COMPLEX:Q00653_Q01201 P14780\n", + "P16591 P16284\n", + "COMPLEX:Q04206_Q04864 P16284\n", + "COMPLEX:Q00653_Q01201 P16284\n", + "Q03181 P01137\n", + "P23443 P01137\n", + "P01137 P23443\n", + "P01375 P23443\n", + "P23443 Q9H3D4\n", + "P31749 P23443\n", + "P48061 Q92569\n", + "Q92569 P31749\n", + "P01375 P42574\n", + "P42574 O14920\n", + "P42574 Q9H3D4\n", + "P42574 P31749\n", + "P48061 O00329\n", + "O00329 P31749\n", + "P01137 P48061\n", + "COMPLEX:Q04206_Q04864 P48061\n", + "COMPLEX:Q00653_Q01201 P48061\n", + "P01375 P01137\n", + "P01137 P31749\n", + "P31749 P01137\n", + "COMPLEX:Q04206_Q04864 P01137\n", + "COMPLEX:Q00653_Q01201 P01137\n", + "O14896 P01137\n", + "P01375 O14920\n", + "P01375 Q9Y6K9\n", + "P01375 O15111\n", + "Q9H3D4 P01375\n", + "P01375 P31749\n", + "COMPLEX:Q04206_Q04864 P01375\n", + "COMPLEX:Q00653_Q01201 P01375\n", + "P01375 P49137\n", + "P53350 P01375\n", + "P01375 O14896\n", + "O14896 P01375\n", + "Q9Y6K9 O14920\n", + "O15111 O14920\n", + "O14920 Q9H3D4\n", + "P31749 O14920\n", + "Q99759 O14920\n", + "P53350 O14920\n", + "Q9Y2U5 O14920\n", + "Q14164 COMPLEX:Q04206_Q04864\n", + "COMPLEX:Q04206_Q04864 Q14164\n", + "COMPLEX:Q00653_Q01201 Q14164\n", + "Q9Y6K9 O15111\n", + "P31749 Q9Y6K9\n", + "Q99759 Q9Y6K9\n", + "P41279 Q9Y6K9\n", + "Q9Y2U5 Q9Y6K9\n", + "Q9H3D4 O15111\n", + "P31749 O15111\n", + "O15111 COMPLEX:Q00653_Q01201\n", + "Q99759 O15111\n", + "P41279 O15111\n", + "Q9Y2U5 O15111\n", + "Q9H3D4 P31749\n", + "COMPLEX:Q04206_Q04864 Q9H3D4\n", + "COMPLEX:Q00653_Q01201 Q9H3D4\n", + "P53350 Q9H3D4\n", + "COMPLEX:Q04206_Q04864 P31749\n", + "COMPLEX:Q00653_Q01201 P31749\n", + "P31749 P41279\n", + "COMPLEX:Q04206_Q04864 P53350\n", + "COMPLEX:Q04206_Q04864 P41279\n", + "COMPLEX:Q00653_Q01201 P53350\n", + "COMPLEX:Q00653_Q01201 P41279\n", + "P49137 P53350\n", + "P41279 P53350\n", + "looking for paths in the network with length: 0 for node VIM and PTK2B\n", + "looking for paths in the network with length: 1 for node VIM and PTK2B\n", + "looking for paths in the network with length: 2 for node VIM and PTK2B\n", + "Found a path!\n", + "[['VIM', 'STAT3', 'PTK2B']]\n", + "looking for paths in the network with length: 0 for node VIM and COL1A1\n", + "looking for paths in the network with length: 1 for node VIM and COL1A1\n", + "looking for paths in the network with length: 2 for node VIM and COL1A1\n", + "Found a path!\n", + "[['VIM', 'CASP3', 'COL1A1'], ['VIM', 'CASP7', 'COL1A1']]\n", + "looking for paths in the network with length: 0 for node MAP4K4 and PTK2B\n", + "looking for paths in the network with length: 1 for node MAP4K4 and PTK2B\n", + "looking for paths in the network with length: 2 for node MAP4K4 and PTK2B\n", + "looking for paths in the network with length: 3 for node MAP4K4 and PTK2B\n", + "Found a path!\n", + "[['MAP4K4', 'CHUK', 'MYC', 'PTK2B'], ['MAP4K4', 'TNF', 'PIK3CG', 'PTK2B'], ['MAP4K4', 'TNF', 'TXN', 'PTK2B']]\n", + "looking for paths in the network with length: 0 for node MAP4K4 and COL1A1\n", + "looking for paths in the network with length: 1 for node MAP4K4 and COL1A1\n", + "looking for paths in the network with length: 2 for node MAP4K4 and COL1A1\n", + "looking for paths in the network with length: 3 for node MAP4K4 and COL1A1\n", + "Found a path!\n", + "[['MAP4K4', 'IKBKB', 'NFKB1', 'COL1A1'], ['MAP4K4', 'IKBKG', 'NFKB1', 'COL1A1'], ['MAP4K4', 'MAP3K3', 'NFKB1', 'COL1A1'], ['MAP4K4', 'MAP3K2', 'NFKB1', 'COL1A1'], ['MAP4K4', 'CHUK', 'NFKB1', 'COL1A1'], ['MAP4K4', 'TNF', 'TGFB1', 'COL1A1'], ['MAP4K4', 'TNF', 'NFKB1', 'COL1A1'], ['MAP4K4', 'TNF', 'RHOA', 'COL1A1'], ['MAP4K4', 'IKBKE', 'NFKB1', 'COL1A1'], ['MAP4K4', 'EPHB1', 'SRC', 'COL1A1'], ['MAP4K4', 'PPARG', 'SRC', 'COL1A1']]\n", + "looking for paths in the network with length: 0 for node PTK2B and COL1A1\n", + "looking for paths in the network with length: 1 for node PTK2B and COL1A1\n", + "looking for paths in the network with length: 2 for node PTK2B and COL1A1\n", + "Found a path!\n", + "[['PTK2B', 'RAC1', 'COL1A1'], ['PTK2B', 'SRC', 'COL1A1'], ['PTK2B', 'PIK3CA', 'COL1A1'], ['PTK2B', 'ITGA4', 'COL1A1']]\n", + "CPU times: user 15min 18s, sys: 436 ms, total: 15min 18s\n", + "Wall time: 15min 18s\n" + ] + }, + { + "name": "stdout", + "output_type": "stream", + "text": [ + "P54762 Q05397\n", + "COMPLEX:P05412_P53539 P12830\n", + "COMPLEX:P19838_Q04206 P12830\n", + "COMPLEX:P17535_P53539 P12830\n", + "COMPLEX:Q01201 P12830\n", + "COMPLEX:P15408_P17275 P12830\n", + "COMPLEX:P15407_P17535 P12830\n", + "COMPLEX:P01100_P17275 P12830\n", + "COMPLEX:P19838_Q04864 P12830\n", + "COMPLEX:Q04206 P12830\n", + "COMPLEX:P19838_Q01201 P12830\n", + "COMPLEX:P15407_P17275 P12830\n", + "COMPLEX:P05412_P17275 P12830\n", + "COMPLEX:P17535 P12830\n", + "COMPLEX:Q00653_Q01201 P12830\n", + "COMPLEX:P17275_P53539 P12830\n", + "COMPLEX:P19838_Q00653 P12830\n", + "COMPLEX:P15408_P17535 P12830\n", + "COMPLEX:Q00653_Q04206 P12830\n", + "COMPLEX:P19838 P12830\n", + "COMPLEX:Q04864 P12830\n", + "COMPLEX:P05412_P17535 P12830\n", + "COMPLEX:P01100_P05412 P12830\n", + "COMPLEX:P17275 P12830\n", + "COMPLEX:P05412_P15407 P12830\n", + "COMPLEX:P05412 P12830\n", + "COMPLEX:P01100_P17535 P12830\n", + "COMPLEX:Q04206_Q04864 P12830\n", + "COMPLEX:Q01201_Q04864 P12830\n", + "COMPLEX:Q00653 P12830\n", + "COMPLEX:Q00653_Q04864 P12830\n", + "COMPLEX:Q01201_Q04206 P12830\n", + "COMPLEX:P05412_P15408 P12830\n", + "COMPLEX:P17275_P17535 P12830\n", + "P37231 P12830\n", + "COMPLEX:P05412_P53539 P19022\n", + "COMPLEX:P19838_Q04206 P19022\n", + "COMPLEX:P17535_P53539 P19022\n", + "COMPLEX:Q01201 P19022\n", + "COMPLEX:P15408_P17275 P19022\n", + "COMPLEX:P15407_P17535 P19022\n", + "COMPLEX:P01100_P17275 P19022\n", + "COMPLEX:P19838_Q04864 P19022\n", + "COMPLEX:Q04206 P19022\n", + "COMPLEX:P19838_Q01201 P19022\n", + "COMPLEX:P15407_P17275 P19022\n", + "COMPLEX:P05412_P17275 P19022\n", + "COMPLEX:P17535 P19022\n", + 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P08670\n", + "O95819 Q9Y2U5\n", + "P54762 O95819\n", + "P37231 O95819\n", + "COMPLEX:P05412_P53539 Q14289\n", + "COMPLEX:P17535_P53539 Q14289\n", + "COMPLEX:P15408_P17275 Q14289\n", + "COMPLEX:P15407_P17535 Q14289\n", + "COMPLEX:P01100_P17275 Q14289\n", + "COMPLEX:P15407_P17275 Q14289\n", + "COMPLEX:P05412_P17275 Q14289\n", + "COMPLEX:P17535 Q14289\n", + "COMPLEX:P17275_P53539 Q14289\n", + "COMPLEX:P15408_P17535 Q14289\n", + "COMPLEX:P05412_P17535 Q14289\n", + "COMPLEX:P01100_P05412 Q14289\n", + "COMPLEX:P17275 Q14289\n", + "COMPLEX:P05412_P15407 Q14289\n", + "COMPLEX:P05412 Q14289\n", + "COMPLEX:P01100_P17535 Q14289\n", + "COMPLEX:P05412_P15408 Q14289\n", + "COMPLEX:P17275_P17535 Q14289\n", + "P19838 P02452\n", + "P08047 P02452\n", + "Q02447 P02452\n", + "COMPLEX:P05412_P53539 P19838\n", + "COMPLEX:P05412_P53539 P08047\n", + "COMPLEX:P05412_P53539 Q02447\n", + "COMPLEX:P05412_P53539 P37231\n", + "COMPLEX:P19838_Q04206 P19838\n", + "COMPLEX:P19838_Q04206 P08047\n", + 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"COMPLEX:P17535 P08047\n", + "Q02447 P08047\n", + "COMPLEX:Q00653_Q01201 P08047\n", + "COMPLEX:P17275_P53539 P08047\n", + "COMPLEX:P19838_Q00653 P08047\n", + "COMPLEX:P15408_P17535 P08047\n", + "COMPLEX:Q00653_Q04206 P08047\n", + "COMPLEX:P19838 P08047\n", + "COMPLEX:Q04864 P08047\n", + "COMPLEX:P05412_P17535 P08047\n", + "P08047 P41235\n", + "COMPLEX:P01100_P05412 P08047\n", + "COMPLEX:P17275 P08047\n", + "COMPLEX:P05412_P15407 P08047\n", + "COMPLEX:P05412 P08047\n", + "COMPLEX:P01100_P17535 P08047\n", + "COMPLEX:Q04206_Q04864 P08047\n", + "COMPLEX:Q01201_Q04864 P08047\n", + "COMPLEX:Q00653 P08047\n", + "COMPLEX:Q00653_Q04864 P08047\n", + "COMPLEX:Q01201_Q04206 P08047\n", + "COMPLEX:P05412_P15408 P08047\n", + "COMPLEX:P17275_P17535 P08047\n", + "P08047 P54762\n", + "P37231 P08047\n", + "COMPLEX:P01100_P17275 Q02447\n", + "COMPLEX:P01100_P17275 P37231\n", + "COMPLEX:P19838_Q04864 Q02447\n", + "COMPLEX:P19838_Q04864 P42229\n", + "COMPLEX:P19838_Q04864 P41235\n", + "COMPLEX:P19838_Q04864 P37231\n", + "COMPLEX:Q04206 Q02447\n", + "COMPLEX:Q04206 P42229\n", + "COMPLEX:Q04206 P41235\n", + "COMPLEX:Q04206 P37231\n", + "COMPLEX:P19838_Q01201 Q02447\n", + "COMPLEX:P19838_Q01201 P42229\n", + "COMPLEX:P19838_Q01201 P41235\n", + "COMPLEX:P19838_Q01201 P37231\n", + "COMPLEX:P15407_P17275 Q02447\n", + "COMPLEX:P15407_P17275 P37231\n", + "COMPLEX:P05412_P17275 Q02447\n", + "COMPLEX:P05412_P17275 P37231\n", + "COMPLEX:P17535 Q02447\n", + "COMPLEX:P17535 P37231\n", + "COMPLEX:Q00653_Q01201 Q02447\n", + "COMPLEX:P17275_P53539 Q02447\n", + "COMPLEX:P19838_Q00653 Q02447\n", + "COMPLEX:P15408_P17535 Q02447\n", + "COMPLEX:Q00653_Q04206 Q02447\n", + "COMPLEX:P19838 Q02447\n", + "COMPLEX:Q04864 Q02447\n", + "COMPLEX:P05412_P17535 Q02447\n", + "COMPLEX:P01100_P05412 Q02447\n", + "COMPLEX:P17275 Q02447\n", + "COMPLEX:P05412_P15407 Q02447\n", + "COMPLEX:P05412 Q02447\n", + "COMPLEX:P01100_P17535 Q02447\n", + "COMPLEX:Q04206_Q04864 Q02447\n", + "COMPLEX:Q01201_Q04864 Q02447\n", + "COMPLEX:Q00653 Q02447\n", + "COMPLEX:Q00653_Q04864 Q02447\n", + "COMPLEX:Q01201_Q04206 Q02447\n", + "COMPLEX:P05412_P15408 Q02447\n", + "COMPLEX:P17275_P17535 Q02447\n", + "COMPLEX:Q00653_Q01201 P42229\n", + "COMPLEX:P19838_Q00653 P42229\n", + "COMPLEX:Q00653_Q04206 P42229\n", + "COMPLEX:P19838 P42229\n", + "COMPLEX:Q04864 P42229\n", + "COMPLEX:Q04206_Q04864 P42229\n", + "COMPLEX:Q01201_Q04864 P42229\n", + "COMPLEX:Q00653 P42229\n", + "COMPLEX:Q00653_Q04864 P42229\n", + "COMPLEX:Q01201_Q04206 P42229\n", + "P37231 P42229\n", + "COMPLEX:Q00653_Q01201 P41235\n", + "COMPLEX:Q00653_Q01201 P37231\n", + "COMPLEX:P17275_P53539 P37231\n", + "COMPLEX:P19838_Q00653 P41235\n", + "COMPLEX:P19838_Q00653 P37231\n", + "COMPLEX:P15408_P17535 P37231\n", + "COMPLEX:Q00653_Q04206 P41235\n", + "COMPLEX:Q00653_Q04206 P37231\n", + "COMPLEX:P19838 P41235\n", + "COMPLEX:P19838 P37231\n", + "COMPLEX:Q04864 P41235\n", + "COMPLEX:Q04864 P37231\n", + "COMPLEX:P05412_P17535 P37231\n", + "COMPLEX:Q04206_Q04864 P41235\n", + "COMPLEX:Q01201_Q04864 P41235\n", + "COMPLEX:Q00653 P41235\n", + "COMPLEX:Q00653_Q04864 P41235\n", + "COMPLEX:Q01201_Q04206 P41235\n", + "COMPLEX:P01100_P05412 P37231\n", + "COMPLEX:P17275 P37231\n", + "COMPLEX:P05412_P15407 P37231\n", + "COMPLEX:P05412 P37231\n", + "COMPLEX:P01100_P17535 P37231\n", + "COMPLEX:Q04206_Q04864 P37231\n", + "COMPLEX:Q01201_Q04864 P37231\n", + "COMPLEX:Q00653 P37231\n", + "COMPLEX:Q00653_Q04864 P37231\n", + "COMPLEX:Q01201_Q04206 P37231\n", + "COMPLEX:P05412_P15408 P37231\n", + "COMPLEX:P17275_P17535 P37231\n", + "looking for paths in the network with length: 0 for node SRC and PTK2B\n", + "looking for paths in the network with length: 1 for node SRC and PTK2B\n", + "Found a path!\n", + "[['SRC', 'PTK2B']]\n", + "looking for paths in the network with length: 0 for node SRC and COL1A1\n", + "looking for paths in the network with length: 1 for node SRC and COL1A1\n", + "Found a path!\n", + "[['SRC', 'COL1A1']]\n", + "looking for paths in the network with length: 0 for node NOTCH1 and PTK2\n", + "looking for paths in the network with length: 1 for node NOTCH1 and PTK2\n", + "looking for paths in the network with length: 2 for node NOTCH1 and PTK2\n", + "Found a path!\n", + "[['NOTCH1', 'RELB', 'PTK2'], ['NOTCH1', 'COMPLEX:P19838_Q04864', 'PTK2'], ['NOTCH1', 'COMPLEX:Q00653_Q01201', 'PTK2'], ['NOTCH1', 'RELA', 'PTK2'], ['NOTCH1', 'NFKB1', 'PTK2'], ['NOTCH1', 'COMPLEX:Q00653_Q04206', 'PTK2'], ['NOTCH1', 'COMPLEX:P19838_Q04206', 'PTK2'], ['NOTCH1', 'COMPLEX:P19838_Q01201', 'PTK2'], ['NOTCH1', 'COMPLEX:Q04206_Q04864', 'PTK2'], ['NOTCH1', 'COMPLEX:P19838_Q00653', 'PTK2'], ['NOTCH1', 'REL', 'PTK2'], ['NOTCH1', 'COMPLEX:Q01201_Q04206', 'PTK2'], ['NOTCH1', 'COMPLEX:Q01201_Q04864', 'PTK2'], ['NOTCH1', 'NFKB2', 'PTK2'], ['NOTCH1', 'COMPLEX:Q00653_Q04864', 'PTK2']]\n", + "looking for paths in the network with length: 0 for node NOTCH1 and CDH1\n", + "looking for paths in the network with length: 1 for node NOTCH1 and CDH1\n", + "looking for paths in the network with length: 2 for node NOTCH1 and CDH1\n", + "Found a path!\n", + "[['NOTCH1', 'RELB', 'CDH1'], ['NOTCH1', 'COMPLEX:P19838_Q04864', 'CDH1'], ['NOTCH1', 'COMPLEX:Q00653_Q01201', 'CDH1'], ['NOTCH1', 'RELA', 'CDH1'], ['NOTCH1', 'PPARG', 'CDH1'], ['NOTCH1', 'NFKB1', 'CDH1'], ['NOTCH1', 'COMPLEX:Q00653_Q04206', 'CDH1'], ['NOTCH1', 'COMPLEX:P19838_Q04206', 'CDH1'], ['NOTCH1', 'COMPLEX:P19838_Q01201', 'CDH1'], ['NOTCH1', 'COMPLEX:Q04206_Q04864', 'CDH1'], ['NOTCH1', 'COMPLEX:P19838_Q00653', 'CDH1'], ['NOTCH1', 'REL', 'CDH1'], ['NOTCH1', 'COMPLEX:Q01201_Q04206', 'CDH1'], ['NOTCH1', 'COMPLEX:Q01201_Q04864', 'CDH1'], ['NOTCH1', 'NFKB2', 'CDH1'], ['NOTCH1', 'COMPLEX:Q00653_Q04864', 'CDH1']]\n", + "looking for paths in the network with length: 0 for node NOTCH1 and CDH2\n", + "looking for paths in the network with length: 1 for node NOTCH1 and CDH2\n", + "Found a path!\n", + "[['NOTCH1', 'CDH2']]\n", + "looking for paths in the network with length: 0 for node NOTCH1 and VIM\n", + "looking for paths in the network with length: 1 for node NOTCH1 and VIM\n", + "looking for paths in the network with length: 2 for node NOTCH1 and VIM\n", + "Found a path!\n", + "[['NOTCH1', 'RELB', 'VIM'], ['NOTCH1', 'SP3', 'VIM'], ['NOTCH1', 'COMPLEX:P19838_Q04864', 'VIM'], ['NOTCH1', 'COMPLEX:Q00653_Q01201', 'VIM'], ['NOTCH1', 'RELA', 'VIM'], ['NOTCH1', 'NFKB1', 'VIM'], ['NOTCH1', 'SP1', 'VIM'], ['NOTCH1', 'COMPLEX:Q00653_Q04206', 'VIM'], ['NOTCH1', 'COMPLEX:P19838_Q04206', 'VIM'], ['NOTCH1', 'COMPLEX:P19838_Q01201', 'VIM'], ['NOTCH1', 'COMPLEX:Q04206_Q04864', 'VIM'], ['NOTCH1', 'COMPLEX:P19838_Q00653', 'VIM'], ['NOTCH1', 'REL', 'VIM'], ['NOTCH1', 'NFKB1', 'VIM'], ['NOTCH1', 'COMPLEX:Q01201_Q04206', 'VIM'], ['NOTCH1', 'COMPLEX:Q01201_Q04864', 'VIM'], ['NOTCH1', 'NFKB2', 'VIM'], ['NOTCH1', 'COMPLEX:Q00653_Q04864', 'VIM']]\n", + "looking for paths in the network with length: 0 for node NOTCH1 and MAP4K4\n", + "looking for paths in the network with length: 1 for node NOTCH1 and MAP4K4\n", + "looking for paths in the network with length: 2 for node NOTCH1 and MAP4K4\n", + "Found a path!\n", + "[['NOTCH1', 'PPARG', 'MAP4K4']]\n", + "looking for paths in the network with length: 0 for node NOTCH1 and PTK2B\n", + "looking for paths in the network with length: 1 for node NOTCH1 and PTK2B\n", + "looking for paths in the network with length: 2 for node NOTCH1 and PTK2B\n", + "looking for paths in the network with length: 3 for node NOTCH1 and PTK2B\n" + ] + }, + { + "name": "stdout", + "output_type": "stream", + "text": [ + "Found a path!\n", + "[['NOTCH1', 'RELB', 'SRC', 'PTK2B'], ['NOTCH1', 'RELB', 'PTK2', 'PTK2B'], ['NOTCH1', 'SP3', 'COMPLEX:P15407_P17275', 'PTK2B'], ['NOTCH1', 'SP3', 'COMPLEX:P05412_P53539', 'PTK2B'], ['NOTCH1', 'SP3', 'COMPLEX:P05412_P17535', 'PTK2B'], ['NOTCH1', 'SP3', 'COMPLEX:P17275_P53539', 'PTK2B'], ['NOTCH1', 'SP3', 'COMPLEX:P05412_P15407', 'PTK2B'], ['NOTCH1', 'SP3', 'COMPLEX:P05412_P17275', 'PTK2B'], ['NOTCH1', 'SP3', 'COMPLEX:P01100_P17275', 'PTK2B'], ['NOTCH1', 'SP3', 'JUND', 'PTK2B'], ['NOTCH1', 'SP3', 'COMPLEX:P05412_P15408', 'PTK2B'], ['NOTCH1', 'SP3', 'COMPLEX:P01100_P05412', 'PTK2B'], ['NOTCH1', 'SP3', 'COMPLEX:P17535_P53539', 'PTK2B'], ['NOTCH1', 'SP3', 'SRC', 'PTK2B'], ['NOTCH1', 'SP3', 'COMPLEX:P15408_P17535', 'PTK2B'], ['NOTCH1', 'SP3', 'JUN', 'PTK2B'], ['NOTCH1', 'SP3', 'JUNB', 'PTK2B'], ['NOTCH1', 'SP3', 'COMPLEX:P15408_P17275', 'PTK2B'], ['NOTCH1', 'SP3', 'COMPLEX:P01100_P17535', 'PTK2B'], ['NOTCH1', 'SP3', 'COMPLEX:P15407_P17535', 'PTK2B'], ['NOTCH1', 'SP3', 'COMPLEX:P17275_P17535', 'PTK2B'], ['NOTCH1', 'COL1A1', 'SRC', 'PTK2B'], ['NOTCH1', 'COMPLEX:P19838_Q04864', 'SRC', 'PTK2B'], ['NOTCH1', 'COMPLEX:P19838_Q04864', 'PTK2', 'PTK2B'], ['NOTCH1', 'COMPLEX:Q00653_Q01201', 'SRC', 'PTK2B'], ['NOTCH1', 'COMPLEX:Q00653_Q01201', 'PTK2', 'PTK2B'], ['NOTCH1', 'CDH2', 'COMPLEX:P15407_P17275', 'PTK2B'], ['NOTCH1', 'CDH2', 'COMPLEX:P05412_P53539', 'PTK2B'], ['NOTCH1', 'CDH2', 'COMPLEX:P05412_P17535', 'PTK2B'], ['NOTCH1', 'CDH2', 'COMPLEX:P17275_P53539', 'PTK2B'], ['NOTCH1', 'CDH2', 'COMPLEX:P05412_P15407', 'PTK2B'], ['NOTCH1', 'CDH2', 'COMPLEX:P05412_P17275', 'PTK2B'], ['NOTCH1', 'CDH2', 'COMPLEX:P01100_P17275', 'PTK2B'], ['NOTCH1', 'CDH2', 'JUND', 'PTK2B'], ['NOTCH1', 'CDH2', 'COMPLEX:P05412_P15408', 'PTK2B'], ['NOTCH1', 'CDH2', 'COMPLEX:P01100_P05412', 'PTK2B'], ['NOTCH1', 'CDH2', 'COMPLEX:P17535_P53539', 'PTK2B'], ['NOTCH1', 'CDH2', 'SRC', 'PTK2B'], ['NOTCH1', 'CDH2', 'COMPLEX:P15408_P17535', 'PTK2B'], ['NOTCH1', 'CDH2', 'JUN', 'PTK2B'], ['NOTCH1', 'CDH2', 'JUNB', 'PTK2B'], ['NOTCH1', 'CDH2', 'COMPLEX:P15408_P17275', 'PTK2B'], ['NOTCH1', 'CDH2', 'COMPLEX:P01100_P17535', 'PTK2B'], ['NOTCH1', 'CDH2', 'COMPLEX:P15407_P17535', 'PTK2B'], ['NOTCH1', 'CDH2', 'COMPLEX:P17275_P17535', 'PTK2B'], ['NOTCH1', 'RELA', 'SRC', 'PTK2B'], ['NOTCH1', 'RELA', 'PTK2', 'PTK2B'], ['NOTCH1', 'PPARG', 'COMPLEX:P15407_P17275', 'PTK2B'], ['NOTCH1', 'PPARG', 'COMPLEX:P05412_P53539', 'PTK2B'], ['NOTCH1', 'PPARG', 'COMPLEX:P05412_P17535', 'PTK2B'], ['NOTCH1', 'PPARG', 'COMPLEX:P17275_P53539', 'PTK2B'], ['NOTCH1', 'PPARG', 'COMPLEX:P05412_P15407', 'PTK2B'], ['NOTCH1', 'PPARG', 'COMPLEX:P05412_P17275', 'PTK2B'], ['NOTCH1', 'PPARG', 'COMPLEX:P01100_P17275', 'PTK2B'], ['NOTCH1', 'PPARG', 'JUND', 'PTK2B'], ['NOTCH1', 'PPARG', 'COMPLEX:P05412_P15408', 'PTK2B'], ['NOTCH1', 'PPARG', 'COMPLEX:P01100_P05412', 'PTK2B'], ['NOTCH1', 'PPARG', 'COMPLEX:P17535_P53539', 'PTK2B'], ['NOTCH1', 'PPARG', 'SRC', 'PTK2B'], ['NOTCH1', 'PPARG', 'COMPLEX:P15408_P17535', 'PTK2B'], ['NOTCH1', 'PPARG', 'JUN', 'PTK2B'], ['NOTCH1', 'PPARG', 'JUNB', 'PTK2B'], ['NOTCH1', 'PPARG', 'COMPLEX:P15408_P17275', 'PTK2B'], ['NOTCH1', 'PPARG', 'COMPLEX:P01100_P17535', 'PTK2B'], ['NOTCH1', 'PPARG', 'COMPLEX:P15407_P17535', 'PTK2B'], ['NOTCH1', 'PPARG', 'COMPLEX:P17275_P17535', 'PTK2B'], ['NOTCH1', 'NFKB1', 'SRC', 'PTK2B'], ['NOTCH1', 'NFKB1', 'PTK2', 'PTK2B'], ['NOTCH1', 'SP1', 'COMPLEX:P15407_P17275', 'PTK2B'], ['NOTCH1', 'SP1', 'COMPLEX:P05412_P53539', 'PTK2B'], ['NOTCH1', 'SP1', 'COMPLEX:P05412_P17535', 'PTK2B'], ['NOTCH1', 'SP1', 'COMPLEX:P17275_P53539', 'PTK2B'], ['NOTCH1', 'SP1', 'COMPLEX:P05412_P15407', 'PTK2B'], ['NOTCH1', 'SP1', 'COMPLEX:P05412_P17275', 'PTK2B'], ['NOTCH1', 'SP1', 'COMPLEX:P01100_P17275', 'PTK2B'], ['NOTCH1', 'SP1', 'JUND', 'PTK2B'], ['NOTCH1', 'SP1', 'COMPLEX:P05412_P15408', 'PTK2B'], ['NOTCH1', 'SP1', 'COMPLEX:P01100_P05412', 'PTK2B'], ['NOTCH1', 'SP1', 'COMPLEX:P17535_P53539', 'PTK2B'], ['NOTCH1', 'SP1', 'SRC', 'PTK2B'], ['NOTCH1', 'SP1', 'COMPLEX:P15408_P17535', 'PTK2B'], ['NOTCH1', 'SP1', 'JUN', 'PTK2B'], ['NOTCH1', 'SP1', 'JUNB', 'PTK2B'], ['NOTCH1', 'SP1', 'COMPLEX:P15408_P17275', 'PTK2B'], ['NOTCH1', 'SP1', 'COMPLEX:P01100_P17535', 'PTK2B'], ['NOTCH1', 'SP1', 'COMPLEX:P15407_P17535', 'PTK2B'], ['NOTCH1', 'SP1', 'COMPLEX:P17275_P17535', 'PTK2B'], ['NOTCH1', 'COMPLEX:Q00653_Q04206', 'SRC', 'PTK2B'], ['NOTCH1', 'COMPLEX:Q00653_Q04206', 'PTK2', 'PTK2B'], ['NOTCH1', 'COMPLEX:P19838_Q04206', 'SRC', 'PTK2B'], ['NOTCH1', 'COMPLEX:P19838_Q04206', 'PTK2', 'PTK2B'], ['NOTCH1', 'COMPLEX:P19838_Q01201', 'SRC', 'PTK2B'], ['NOTCH1', 'COMPLEX:P19838_Q01201', 'PTK2', 'PTK2B'], ['NOTCH1', 'COMPLEX:Q04206_Q04864', 'SRC', 'PTK2B'], ['NOTCH1', 'COMPLEX:Q04206_Q04864', 'PTK2', 'PTK2B'], ['NOTCH1', 'COMPLEX:P19838_Q00653', 'SRC', 'PTK2B'], ['NOTCH1', 'COMPLEX:P19838_Q00653', 'PTK2', 'PTK2B'], ['NOTCH1', 'REL', 'SRC', 'PTK2B'], ['NOTCH1', 'REL', 'PTK2', 'PTK2B'], ['NOTCH1', 'NFKB1', 'COMPLEX:P15407_P17275', 'PTK2B'], ['NOTCH1', 'NFKB1', 'COMPLEX:P05412_P53539', 'PTK2B'], ['NOTCH1', 'NFKB1', 'COMPLEX:P05412_P17535', 'PTK2B'], ['NOTCH1', 'NFKB1', 'COMPLEX:P17275_P53539', 'PTK2B'], ['NOTCH1', 'NFKB1', 'COMPLEX:P05412_P15407', 'PTK2B'], ['NOTCH1', 'NFKB1', 'COMPLEX:P05412_P17275', 'PTK2B'], ['NOTCH1', 'NFKB1', 'COMPLEX:P01100_P17275', 'PTK2B'], ['NOTCH1', 'NFKB1', 'JUND', 'PTK2B'], ['NOTCH1', 'NFKB1', 'COMPLEX:P05412_P15408', 'PTK2B'], ['NOTCH1', 'NFKB1', 'COMPLEX:P01100_P05412', 'PTK2B'], ['NOTCH1', 'NFKB1', 'COMPLEX:P17535_P53539', 'PTK2B'], ['NOTCH1', 'NFKB1', 'SRC', 'PTK2B'], ['NOTCH1', 'NFKB1', 'COMPLEX:P15408_P17535', 'PTK2B'], ['NOTCH1', 'NFKB1', 'JUN', 'PTK2B'], ['NOTCH1', 'NFKB1', 'JUNB', 'PTK2B'], ['NOTCH1', 'NFKB1', 'COMPLEX:P15408_P17275', 'PTK2B'], ['NOTCH1', 'NFKB1', 'COMPLEX:P01100_P17535', 'PTK2B'], ['NOTCH1', 'NFKB1', 'COMPLEX:P15407_P17535', 'PTK2B'], ['NOTCH1', 'NFKB1', 'COMPLEX:P17275_P17535', 'PTK2B'], ['NOTCH1', 'COMPLEX:Q01201_Q04206', 'SRC', 'PTK2B'], ['NOTCH1', 'COMPLEX:Q01201_Q04206', 'PTK2', 'PTK2B'], ['NOTCH1', 'COMPLEX:Q01201_Q04864', 'SRC', 'PTK2B'], ['NOTCH1', 'COMPLEX:Q01201_Q04864', 'PTK2', 'PTK2B'], ['NOTCH1', 'NFKB2', 'SRC', 'PTK2B'], ['NOTCH1', 'NFKB2', 'PTK2', 'PTK2B'], ['NOTCH1', 'COMPLEX:Q00653_Q04864', 'SRC', 'PTK2B'], ['NOTCH1', 'COMPLEX:Q00653_Q04864', 'PTK2', 'PTK2B']]\n", + "looking for paths in the network with length: 0 for node NOTCH1 and COL1A1\n", + "looking for paths in the network with length: 1 for node NOTCH1 and COL1A1\n", + "Found a path!\n", + "[['NOTCH1', 'COL1A1']]\n", + "looking for paths in the network with length: 0 for node PTK2 and CDH1\n", + "looking for paths in the network with length: 1 for node PTK2 and CDH1\n", + "looking for paths in the network with length: 2 for node PTK2 and CDH1\n", + "Found a path!\n", + "[['PTK2', 'RELB', 'CDH1'], ['PTK2', 'COMPLEX:P19838_Q04864', 'CDH1'], ['PTK2', 'COMPLEX:Q00653_Q01201', 'CDH1'], ['PTK2', 'SRC', 'CDH1'], ['PTK2', 'RELA', 'CDH1'], ['PTK2', 'NFKB1', 'CDH1'], ['PTK2', 'COMPLEX:Q00653_Q04206', 'CDH1'], ['PTK2', 'COMPLEX:P19838_Q04206', 'CDH1'], ['PTK2', 'COMPLEX:P19838_Q01201', 'CDH1'], ['PTK2', 'COMPLEX:Q04206_Q04864', 'CDH1'], ['PTK2', 'COMPLEX:P19838_Q00653', 'CDH1'], ['PTK2', 'REL', 'CDH1'], ['PTK2', 'COMPLEX:Q01201_Q04206', 'CDH1'], ['PTK2', 'COMPLEX:Q01201_Q04864', 'CDH1'], ['PTK2', 'NFKB2', 'CDH1'], ['PTK2', 'COMPLEX:Q00653_Q04864', 'CDH1']]\n", + "looking for paths in the network with length: 0 for node PTK2 and CDH2\n", + "looking for paths in the network with length: 1 for node PTK2 and CDH2\n", + "looking for paths in the network with length: 2 for node PTK2 and CDH2\n", + "Found a path!\n", + "[['PTK2', 'RELB', 'CDH2'], ['PTK2', 'COMPLEX:P19838_Q04864', 'CDH2'], ['PTK2', 'COMPLEX:Q00653_Q01201', 'CDH2'], ['PTK2', 'SRC', 'CDH2'], ['PTK2', 'RELA', 'CDH2'], ['PTK2', 'NFKB1', 'CDH2'], ['PTK2', 'COMPLEX:Q00653_Q04206', 'CDH2'], ['PTK2', 'COMPLEX:P19838_Q04206', 'CDH2'], ['PTK2', 'COMPLEX:P19838_Q01201', 'CDH2'], ['PTK2', 'COMPLEX:Q04206_Q04864', 'CDH2'], ['PTK2', 'COMPLEX:P19838_Q00653', 'CDH2'], ['PTK2', 'REL', 'CDH2'], ['PTK2', 'COMPLEX:Q01201_Q04206', 'CDH2'], ['PTK2', 'COMPLEX:Q01201_Q04864', 'CDH2'], ['PTK2', 'NFKB2', 'CDH2'], ['PTK2', 'COMPLEX:Q00653_Q04864', 'CDH2']]\n", + "looking for paths in the network with length: 0 for node PTK2 and VIM\n", + "looking for paths in the network with length: 1 for node PTK2 and VIM\n", + "looking for paths in the network with length: 2 for node PTK2 and VIM\n", + "Found a path!\n", + "[['PTK2', 'RELB', 'VIM'], ['PTK2', 'COMPLEX:P19838_Q04864', 'VIM'], ['PTK2', 'COMPLEX:Q00653_Q01201', 'VIM'], ['PTK2', 'RELA', 'VIM'], ['PTK2', 'NFKB1', 'VIM'], ['PTK2', 'COMPLEX:Q00653_Q04206', 'VIM'], ['PTK2', 'COMPLEX:P19838_Q04206', 'VIM'], ['PTK2', 'COMPLEX:P19838_Q01201', 'VIM'], ['PTK2', 'COMPLEX:Q04206_Q04864', 'VIM'], ['PTK2', 'COMPLEX:P19838_Q00653', 'VIM'], ['PTK2', 'REL', 'VIM'], ['PTK2', 'COMPLEX:Q01201_Q04206', 'VIM'], ['PTK2', 'COMPLEX:Q01201_Q04864', 'VIM'], ['PTK2', 'NFKB2', 'VIM'], ['PTK2', 'COMPLEX:Q00653_Q04864', 'VIM']]\n", + "looking for paths in the network with length: 0 for node PTK2 and MAP4K4\n", + "looking for paths in the network with length: 1 for node PTK2 and MAP4K4\n", + "looking for paths in the network with length: 2 for node PTK2 and MAP4K4\n", + "Found a path!\n", + "[['PTK2', 'EPHB1', 'MAP4K4']]\n", + "looking for paths in the network with length: 0 for node PTK2 and PTK2B\n", + "looking for paths in the network with length: 1 for node PTK2 and PTK2B\n", + "Found a path!\n", + "[['PTK2', 'PTK2B']]\n", + "looking for paths in the network with length: 0 for node PTK2 and COL1A1\n", + "looking for paths in the network with length: 1 for node PTK2 and COL1A1\n", + "looking for paths in the network with length: 2 for node PTK2 and COL1A1\n", + "Found a path!\n", + "[['PTK2', 'SRC', 'COL1A1']]\n", + "looking for paths in the network with length: 0 for node CDH1 and CDH2\n", + "looking for paths in the network with length: 1 for node CDH1 and CDH2\n", + "looking for paths in the network with length: 2 for node CDH1 and CDH2\n", + "Found a path!\n", + "[['CDH1', 'COMPLEX:P15407_P17275', 'CDH2'], ['CDH1', 'COMPLEX:P05412_P53539', 'CDH2'], ['CDH1', 'COMPLEX:P05412_P17535', 'CDH2'], ['CDH1', 'COMPLEX:P17275_P53539', 'CDH2'], ['CDH1', 'COMPLEX:P05412_P15407', 'CDH2'], ['CDH1', 'COMPLEX:P05412_P17275', 'CDH2'], ['CDH1', 'COMPLEX:P01100_P17275', 'CDH2'], ['CDH1', 'NFKB1', 'CDH2'], ['CDH1', 'COMPLEX:P19838_Q04206', 'CDH2'], ['CDH1', 'JUND', 'CDH2'], ['CDH1', 'COMPLEX:P19838_Q00653', 'CDH2'], ['CDH1', 'REL', 'CDH2'], ['CDH1', 'COMPLEX:Q01201_Q04206', 'CDH2'], ['CDH1', 'COMPLEX:Q01201_Q04864', 'CDH2'], ['CDH1', 'NFKB2', 'CDH2'], ['CDH1', 'RELB', 'CDH2'], ['CDH1', 'COMPLEX:P05412_P15408', 'CDH2'], ['CDH1', 'COMPLEX:P19838_Q04864', 'CDH2'], ['CDH1', 'COMPLEX:Q00653_Q01201', 'CDH2'], ['CDH1', 'COMPLEX:P01100_P05412', 'CDH2'], ['CDH1', 'COMPLEX:P17535_P53539', 'CDH2'], ['CDH1', 'SRC', 'CDH2'], ['CDH1', 'COMPLEX:P15408_P17535', 'CDH2'], ['CDH1', 'JUN', 'CDH2'], ['CDH1', 'JUNB', 'CDH2'], ['CDH1', 'RELA', 'CDH2'], ['CDH1', 'PPARG', 'CDH2'], ['CDH1', 'COMPLEX:Q00653_Q04206', 'CDH2'], ['CDH1', 'COMPLEX:P19838_Q01201', 'CDH2'], ['CDH1', 'COMPLEX:P15408_P17275', 'CDH2'], ['CDH1', 'COMPLEX:P01100_P17535', 'CDH2'], ['CDH1', 'COMPLEX:Q04206_Q04864', 'CDH2'], ['CDH1', 'COMPLEX:P15407_P17535', 'CDH2'], ['CDH1', 'COMPLEX:P17275_P17535', 'CDH2'], ['CDH1', 'COMPLEX:Q00653_Q04864', 'CDH2']]\n", + "looking for paths in the network with length: 0 for node CDH1 and VIM\n", + "looking for paths in the network with length: 1 for node CDH1 and VIM\n", + "looking for paths in the network with length: 2 for node CDH1 and VIM\n", + "Found a path!\n", + "[['CDH1', 'COMPLEX:P15407_P17275', 'VIM'], ['CDH1', 'COMPLEX:P05412_P53539', 'VIM'], ['CDH1', 'COMPLEX:P05412_P17535', 'VIM'], ['CDH1', 'COMPLEX:P17275_P53539', 'VIM'], ['CDH1', 'COMPLEX:P05412_P15407', 'VIM'], ['CDH1', 'COMPLEX:P05412_P17275', 'VIM'], ['CDH1', 'COMPLEX:P01100_P17275', 'VIM'], ['CDH1', 'NFKB1', 'VIM'], ['CDH1', 'COMPLEX:P19838_Q04206', 'VIM'], ['CDH1', 'JUND', 'VIM'], ['CDH1', 'COMPLEX:P19838_Q00653', 'VIM'], ['CDH1', 'REL', 'VIM'], ['CDH1', 'COMPLEX:Q01201_Q04206', 'VIM'], ['CDH1', 'COMPLEX:Q01201_Q04864', 'VIM'], ['CDH1', 'NFKB2', 'VIM'], ['CDH1', 'RELB', 'VIM'], ['CDH1', 'COMPLEX:P05412_P15408', 'VIM'], ['CDH1', 'COMPLEX:P19838_Q04864', 'VIM'], ['CDH1', 'COMPLEX:Q00653_Q01201', 'VIM'], ['CDH1', 'COMPLEX:P01100_P05412', 'VIM'], ['CDH1', 'COMPLEX:P17535_P53539', 'VIM'], ['CDH1', 'COMPLEX:P15408_P17535', 'VIM'], ['CDH1', 'JUN', 'VIM'], ['CDH1', 'JUNB', 'VIM'], ['CDH1', 'RELA', 'VIM'], ['CDH1', 'COMPLEX:Q00653_Q04206', 'VIM'], ['CDH1', 'COMPLEX:P19838_Q01201', 'VIM'], ['CDH1', 'COMPLEX:P15408_P17275', 'VIM'], ['CDH1', 'COMPLEX:P01100_P17535', 'VIM'], ['CDH1', 'COMPLEX:Q04206_Q04864', 'VIM'], ['CDH1', 'COMPLEX:P15407_P17535', 'VIM'], ['CDH1', 'COMPLEX:P17275_P17535', 'VIM'], ['CDH1', 'COMPLEX:Q00653_Q04864', 'VIM']]\n", + "looking for paths in the network with length: 0 for node CDH1 and MAP4K4\n", + "looking for paths in the network with length: 1 for node CDH1 and MAP4K4\n", + "looking for paths in the network with length: 2 for node CDH1 and MAP4K4\n", + "Found a path!\n", + "[['CDH1', 'PPARG', 'MAP4K4']]\n", + "looking for paths in the network with length: 0 for node CDH1 and PTK2B\n", + "looking for paths in the network with length: 1 for node CDH1 and PTK2B\n", + "looking for paths in the network with length: 2 for node CDH1 and PTK2B\n", + "Found a path!\n", + "[['CDH1', 'COMPLEX:P15407_P17275', 'PTK2B'], ['CDH1', 'COMPLEX:P05412_P53539', 'PTK2B'], ['CDH1', 'COMPLEX:P05412_P17535', 'PTK2B'], ['CDH1', 'COMPLEX:P17275_P53539', 'PTK2B'], ['CDH1', 'COMPLEX:P05412_P15407', 'PTK2B'], ['CDH1', 'COMPLEX:P05412_P17275', 'PTK2B'], ['CDH1', 'COMPLEX:P01100_P17275', 'PTK2B'], ['CDH1', 'JUND', 'PTK2B'], ['CDH1', 'COMPLEX:P05412_P15408', 'PTK2B'], ['CDH1', 'COMPLEX:P01100_P05412', 'PTK2B'], ['CDH1', 'COMPLEX:P17535_P53539', 'PTK2B'], ['CDH1', 'SRC', 'PTK2B'], ['CDH1', 'COMPLEX:P15408_P17535', 'PTK2B'], ['CDH1', 'JUN', 'PTK2B'], ['CDH1', 'JUNB', 'PTK2B'], ['CDH1', 'COMPLEX:P15408_P17275', 'PTK2B'], ['CDH1', 'COMPLEX:P01100_P17535', 'PTK2B'], ['CDH1', 'COMPLEX:P15407_P17535', 'PTK2B'], ['CDH1', 'COMPLEX:P17275_P17535', 'PTK2B']]\n", + "looking for paths in the network with length: 0 for node CDH1 and COL1A1\n", + "looking for paths in the network with length: 1 for node CDH1 and COL1A1\n", + "looking for paths in the network with length: 2 for node CDH1 and COL1A1\n", + "Found a path!\n", + "[['CDH1', 'SRC', 'COL1A1']]\n", + "looking for paths in the network with length: 0 for node CDH2 and VIM\n", + "looking for paths in the network with length: 1 for node CDH2 and VIM\n", + "looking for paths in the network with length: 2 for node CDH2 and VIM\n", + "Found a path!\n", + "[['CDH2', 'COMPLEX:P15407_P17275', 'VIM'], ['CDH2', 'COMPLEX:P05412_P53539', 'VIM'], ['CDH2', 'COMPLEX:P05412_P17535', 'VIM'], ['CDH2', 'COMPLEX:P17275_P53539', 'VIM'], ['CDH2', 'COMPLEX:P05412_P15407', 'VIM'], ['CDH2', 'COMPLEX:P05412_P17275', 'VIM'], ['CDH2', 'COMPLEX:P01100_P17275', 'VIM'], ['CDH2', 'NFKB1', 'VIM'], ['CDH2', 'COMPLEX:P19838_Q04206', 'VIM'], ['CDH2', 'JUND', 'VIM'], ['CDH2', 'COMPLEX:P19838_Q00653', 'VIM'], ['CDH2', 'REL', 'VIM'], ['CDH2', 'COMPLEX:Q01201_Q04206', 'VIM'], ['CDH2', 'COMPLEX:Q01201_Q04864', 'VIM'], ['CDH2', 'NFKB2', 'VIM'], ['CDH2', 'RELB', 'VIM'], ['CDH2', 'COMPLEX:P05412_P15408', 'VIM'], ['CDH2', 'COMPLEX:P19838_Q04864', 'VIM'], ['CDH2', 'COMPLEX:Q00653_Q01201', 'VIM'], ['CDH2', 'COMPLEX:P01100_P05412', 'VIM'], ['CDH2', 'COMPLEX:P17535_P53539', 'VIM'], ['CDH2', 'COMPLEX:P15408_P17535', 'VIM'], ['CDH2', 'JUN', 'VIM'], ['CDH2', 'JUNB', 'VIM'], ['CDH2', 'RELA', 'VIM'], ['CDH2', 'COMPLEX:Q00653_Q04206', 'VIM'], ['CDH2', 'COMPLEX:P19838_Q01201', 'VIM'], ['CDH2', 'COMPLEX:P15408_P17275', 'VIM'], ['CDH2', 'COMPLEX:P01100_P17535', 'VIM'], ['CDH2', 'COMPLEX:Q04206_Q04864', 'VIM'], ['CDH2', 'COMPLEX:P15407_P17535', 'VIM'], ['CDH2', 'COMPLEX:P17275_P17535', 'VIM'], ['CDH2', 'COMPLEX:Q00653_Q04864', 'VIM']]\n", + "looking for paths in the network with length: 0 for node CDH2 and MAP4K4\n", + "looking for paths in the network with length: 1 for node CDH2 and MAP4K4\n", + "looking for paths in the network with length: 2 for node CDH2 and MAP4K4\n", + "Found a path!\n", + "[['CDH2', 'PPARG', 'MAP4K4']]\n", + "looking for paths in the network with length: 0 for node CDH2 and PTK2B\n", + "looking for paths in the network with length: 1 for node CDH2 and PTK2B\n", + "looking for paths in the network with length: 2 for node CDH2 and PTK2B\n", + "Found a path!\n", + "[['CDH2', 'COMPLEX:P15407_P17275', 'PTK2B'], ['CDH2', 'COMPLEX:P05412_P53539', 'PTK2B'], ['CDH2', 'COMPLEX:P05412_P17535', 'PTK2B'], ['CDH2', 'COMPLEX:P17275_P53539', 'PTK2B'], ['CDH2', 'COMPLEX:P05412_P15407', 'PTK2B'], ['CDH2', 'COMPLEX:P05412_P17275', 'PTK2B'], ['CDH2', 'COMPLEX:P01100_P17275', 'PTK2B'], ['CDH2', 'JUND', 'PTK2B'], ['CDH2', 'COMPLEX:P05412_P15408', 'PTK2B'], ['CDH2', 'COMPLEX:P01100_P05412', 'PTK2B'], ['CDH2', 'COMPLEX:P17535_P53539', 'PTK2B'], ['CDH2', 'SRC', 'PTK2B'], ['CDH2', 'COMPLEX:P15408_P17535', 'PTK2B'], ['CDH2', 'JUN', 'PTK2B'], ['CDH2', 'JUNB', 'PTK2B'], ['CDH2', 'COMPLEX:P15408_P17275', 'PTK2B'], ['CDH2', 'COMPLEX:P01100_P17535', 'PTK2B'], ['CDH2', 'COMPLEX:P15407_P17535', 'PTK2B'], ['CDH2', 'COMPLEX:P17275_P17535', 'PTK2B']]\n", + "looking for paths in the network with length: 0 for node CDH2 and COL1A1\n", + "looking for paths in the network with length: 1 for node CDH2 and COL1A1\n", + "looking for paths in the network with length: 2 for node CDH2 and COL1A1\n", + "Found a path!\n", + "[['CDH2', 'SRC', 'COL1A1'], ['CDH2', 'NOTCH1', 'COL1A1']]\n", + "looking for paths in the network with length: 0 for node VIM and MAP4K4\n", + "looking for paths in the network with length: 1 for node VIM and MAP4K4\n", + "looking for paths in the network with length: 2 for node VIM and MAP4K4\n", + "looking for paths in the network with length: 3 for node VIM and MAP4K4\n", + "Found a path!\n", + "[['VIM', 'STAT5A', 'PPARG', 'MAP4K4'], ['VIM', 'COMPLEX:P15407_P17275', 'PPARG', 'MAP4K4'], ['VIM', 'COMPLEX:P05412_P53539', 'PPARG', 'MAP4K4'], ['VIM', 'COMPLEX:P05412_P17535', 'PPARG', 'MAP4K4'], ['VIM', 'COMPLEX:P17275_P53539', 'PPARG', 'MAP4K4'], ['VIM', 'COMPLEX:P05412_P15407', 'PPARG', 'MAP4K4'], ['VIM', 'COMPLEX:P05412_P17275', 'PPARG', 'MAP4K4'], ['VIM', 'COMPLEX:P01100_P17275', 'PPARG', 'MAP4K4'], ['VIM', 'NFKB1', 'PPARG', 'MAP4K4'], ['VIM', 'COMPLEX:P19838_Q04206', 'PPARG', 'MAP4K4'], ['VIM', 'JUND', 'PPARG', 'MAP4K4'], ['VIM', 'COMPLEX:P19838_Q00653', 'PPARG', 'MAP4K4'], ['VIM', 'REL', 'PPARG', 'MAP4K4'], ['VIM', 'NFKB1', 'MAP3K2', 'MAP4K4'], ['VIM', 'NFKB1', 'PPARG', 'MAP4K4'], ['VIM', 'COMPLEX:Q01201_Q04206', 'PPARG', 'MAP4K4'], ['VIM', 'COMPLEX:Q01201_Q04864', 'PPARG', 'MAP4K4'], ['VIM', 'NFKB2', 'PPARG', 'MAP4K4'], ['VIM', 'RELB', 'PPARG', 'MAP4K4'], ['VIM', 'COMPLEX:P05412_P15408', 'PPARG', 'MAP4K4'], ['VIM', 'COMPLEX:P19838_Q04864', 'PPARG', 'MAP4K4'], ['VIM', 'COMPLEX:Q00653_Q01201', 'PPARG', 'MAP4K4'], ['VIM', 'COMPLEX:P01100_P05412', 'PPARG', 'MAP4K4'], ['VIM', 'COMPLEX:P17535_P53539', 'PPARG', 'MAP4K4'], ['VIM', 'COMPLEX:P15408_P17535', 'PPARG', 'MAP4K4'], ['VIM', 'JUN', 'PPARG', 'MAP4K4'], ['VIM', 'JUNB', 'PPARG', 'MAP4K4'], ['VIM', 'RELA', 'PPARG', 'MAP4K4'], ['VIM', 'SP1', 'EPHB1', 'MAP4K4'], ['VIM', 'SP1', 'PPARG', 'MAP4K4'], ['VIM', 'COMPLEX:Q00653_Q04206', 'PPARG', 'MAP4K4'], ['VIM', 'COMPLEX:P19838_Q01201', 'PPARG', 'MAP4K4'], ['VIM', 'COMPLEX:P15408_P17275', 'PPARG', 'MAP4K4'], ['VIM', 'COMPLEX:P01100_P17535', 'PPARG', 'MAP4K4'], ['VIM', 'COMPLEX:Q04206_Q04864', 'PPARG', 'MAP4K4'], ['VIM', 'COMPLEX:P15407_P17535', 'PPARG', 'MAP4K4'], ['VIM', 'COMPLEX:P17275_P17535', 'PPARG', 'MAP4K4'], ['VIM', 'COMPLEX:Q00653_Q04864', 'PPARG', 'MAP4K4']]\n", + "looking for paths in the network with length: 0 for node VIM and PTK2B\n", + "looking for paths in the network with length: 1 for node VIM and PTK2B\n", + "looking for paths in the network with length: 2 for node VIM and PTK2B\n", + "Found a path!\n", + "[['VIM', 'COMPLEX:P15407_P17275', 'PTK2B'], ['VIM', 'COMPLEX:P05412_P53539', 'PTK2B'], ['VIM', 'COMPLEX:P05412_P17535', 'PTK2B'], ['VIM', 'COMPLEX:P17275_P53539', 'PTK2B'], ['VIM', 'COMPLEX:P05412_P15407', 'PTK2B'], ['VIM', 'COMPLEX:P05412_P17275', 'PTK2B'], ['VIM', 'COMPLEX:P01100_P17275', 'PTK2B'], ['VIM', 'JUND', 'PTK2B'], ['VIM', 'COMPLEX:P05412_P15408', 'PTK2B'], ['VIM', 'COMPLEX:P01100_P05412', 'PTK2B'], ['VIM', 'COMPLEX:P17535_P53539', 'PTK2B'], ['VIM', 'COMPLEX:P15408_P17535', 'PTK2B'], ['VIM', 'JUN', 'PTK2B'], ['VIM', 'JUNB', 'PTK2B'], ['VIM', 'COMPLEX:P15408_P17275', 'PTK2B'], ['VIM', 'COMPLEX:P01100_P17535', 'PTK2B'], ['VIM', 'COMPLEX:P15407_P17535', 'PTK2B'], ['VIM', 'COMPLEX:P17275_P17535', 'PTK2B']]\n", + "looking for paths in the network with length: 0 for node VIM and COL1A1\n", + "looking for paths in the network with length: 1 for node VIM and COL1A1\n", + "looking for paths in the network with length: 2 for node VIM and COL1A1\n", + "Found a path!\n", + "[['VIM', 'SP3', 'COL1A1'], ['VIM', 'NFKB1', 'COL1A1'], ['VIM', 'SP1', 'COL1A1']]\n", + "looking for paths in the network with length: 0 for node MAP4K4 and PTK2B\n", + "looking for paths in the network with length: 1 for node MAP4K4 and PTK2B\n", + "looking for paths in the network with length: 2 for node MAP4K4 and PTK2B\n" + ] + }, + { + "name": "stdout", + "output_type": "stream", + "text": [ + "looking for paths in the network with length: 3 for node MAP4K4 and PTK2B\n", + "Found a path!\n", + "[['MAP4K4', 'EPHB1', 'PTK2', 'PTK2B'], ['MAP4K4', 'EPHB1', 'SRC', 'PTK2B'], ['MAP4K4', 'PPARG', 'COMPLEX:P15407_P17275', 'PTK2B'], ['MAP4K4', 'PPARG', 'COMPLEX:P05412_P53539', 'PTK2B'], ['MAP4K4', 'PPARG', 'COMPLEX:P05412_P17535', 'PTK2B'], ['MAP4K4', 'PPARG', 'COMPLEX:P17275_P53539', 'PTK2B'], ['MAP4K4', 'PPARG', 'COMPLEX:P05412_P15407', 'PTK2B'], ['MAP4K4', 'PPARG', 'COMPLEX:P05412_P17275', 'PTK2B'], ['MAP4K4', 'PPARG', 'COMPLEX:P01100_P17275', 'PTK2B'], ['MAP4K4', 'PPARG', 'JUND', 'PTK2B'], ['MAP4K4', 'PPARG', 'COMPLEX:P05412_P15408', 'PTK2B'], ['MAP4K4', 'PPARG', 'COMPLEX:P01100_P05412', 'PTK2B'], ['MAP4K4', 'PPARG', 'COMPLEX:P17535_P53539', 'PTK2B'], ['MAP4K4', 'PPARG', 'SRC', 'PTK2B'], ['MAP4K4', 'PPARG', 'COMPLEX:P15408_P17535', 'PTK2B'], ['MAP4K4', 'PPARG', 'JUN', 'PTK2B'], ['MAP4K4', 'PPARG', 'JUNB', 'PTK2B'], ['MAP4K4', 'PPARG', 'COMPLEX:P15408_P17275', 'PTK2B'], ['MAP4K4', 'PPARG', 'COMPLEX:P01100_P17535', 'PTK2B'], ['MAP4K4', 'PPARG', 'COMPLEX:P15407_P17535', 'PTK2B'], ['MAP4K4', 'PPARG', 'COMPLEX:P17275_P17535', 'PTK2B'], ['MAP4K4', 'MAP3K2', 'SRC', 'PTK2B']]\n", + "looking for paths in the network with length: 0 for node MAP4K4 and COL1A1\n", + "looking for paths in the network with length: 1 for node MAP4K4 and COL1A1\n", + "looking for paths in the network with length: 2 for node MAP4K4 and COL1A1\n", + "looking for paths in the network with length: 3 for node MAP4K4 and COL1A1\n", + "Found a path!\n", + "[['MAP4K4', 'EPHB1', 'SP1', 'COL1A1'], ['MAP4K4', 'EPHB1', 'SRC', 'COL1A1'], ['MAP4K4', 'PPARG', 'NFKB1', 'COL1A1'], ['MAP4K4', 'PPARG', 'SRC', 'COL1A1'], ['MAP4K4', 'PPARG', 'NOTCH1', 'COL1A1'], ['MAP4K4', 'PPARG', 'SP1', 'COL1A1'], ['MAP4K4', 'MAP3K2', 'NFKB1', 'COL1A1'], ['MAP4K4', 'MAP3K2', 'SRC', 'COL1A1']]\n", + "looking for paths in the network with length: 0 for node PTK2B and COL1A1\n", + "looking for paths in the network with length: 1 for node PTK2B and COL1A1\n", + "looking for paths in the network with length: 2 for node PTK2B and COL1A1\n", + "Found a path!\n", + "[['PTK2B', 'SRC', 'COL1A1']]\n", + "CPU times: user 2min 4s, sys: 36.8 ms, total: 2min 4s\n", + "Wall time: 2min 4s\n" + ] + } + ], + "source": [ + "%%time\n", + "new_net1.complete_connection(mode=\"ALL\", maxlen=6, k_mean=\"tight\", only_signed=True,\n", + " consensus=True, connect_node_when_first_introduced=True)" + ] + }, + { + "cell_type": "code", + "execution_count": 17, + "id": "db61c89d", + "metadata": {}, + "outputs": [ + { + "data": { + "image/svg+xml": [ + "\n", + "\n", + "\n", + "\n", + "\n", + "\n", + "%3\n", + "\n", + "\n", + "\n", + "SRC\n", + "\n", + "SRC\n", + "\n", + "\n", + "\n", + "PTK2\n", + "\n", + "PTK2\n", + "\n", + "\n", + "\n", 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"\n", + "\n", + "\n", + "\n", + "NFKB2->SP1\n", + "\n", + "\n", + "\n", + "\n", + "\n", + "NFKB2->SP3\n", + "\n", + "\n", + "\n", + "\n", + "\n", + "NFKB2->STAT5A\n", + "\n", + "\n", + "\n", + "\n", + "\n", + "NFKB2->HNF4A\n", + "\n", + "\n", + "\n", + "\n", + "\n", + "\n", + "NFKB2->PPARG\n", + "\n", + "\n", + "\n", + "\n", + "\n", + "\n", + "Q00653_Q04864\n", + "\n", + "Q00653_Q04864\n", + "\n", + "\n", + "\n", + "Q00653_Q04864->SRC\n", + "\n", + "\n", + "\n", + "\n", + "\n", + "Q00653_Q04864->PTK2\n", + "\n", + "\n", + "\n", + "\n", + "\n", + "Q00653_Q04864->CDH1\n", + "\n", + "\n", + "\n", + "\n", + "\n", + "Q00653_Q04864->CDH2\n", + "\n", + "\n", + "\n", + "\n", + "\n", + "Q00653_Q04864->NOTCH1\n", + "\n", + "\n", + "\n", + "\n", + "\n", + "Q00653_Q04864->VIM\n", + "\n", + "\n", + "\n", + "\n", + "\n", + "Q00653_Q04864->NFKB1\n", + "\n", + "\n", + "\n", + "\n", + "\n", + "Q00653_Q04864->SP1\n", + "\n", + "\n", + "\n", + "\n", + "\n", + "Q00653_Q04864->SP3\n", + "\n", + "\n", + "\n", + "\n", + "\n", + "Q00653_Q04864->STAT5A\n", + "\n", + "\n", + "\n", + "\n", + "\n", + "Q00653_Q04864->HNF4A\n", + "\n", + "\n", + "\n", + "\n", + "\n", + "\n", + "Q00653_Q04864->PPARG\n", + "\n", + "\n", + "\n", + "\n", + "\n", + "\n", + "Q01201_Q04206\n", + "\n", + "Q01201_Q04206\n", + "\n", + "\n", + "\n", + "Q01201_Q04206->SRC\n", + "\n", + "\n", + "\n", + "\n", + "\n", + "Q01201_Q04206->PTK2\n", + "\n", + "\n", + "\n", + "\n", + "\n", + "Q01201_Q04206->CDH1\n", + "\n", + "\n", + "\n", + "\n", + "\n", + "Q01201_Q04206->CDH2\n", + "\n", + "\n", + "\n", + "\n", + "\n", + "Q01201_Q04206->NOTCH1\n", + "\n", + "\n", + "\n", + "\n", + "\n", + "Q01201_Q04206->VIM\n", + "\n", + "\n", + "\n", + "\n", + "\n", + "Q01201_Q04206->NFKB1\n", + "\n", + "\n", + "\n", + "\n", + "\n", + "Q01201_Q04206->SP1\n", + "\n", + "\n", + "\n", + "\n", + "\n", + "Q01201_Q04206->SP3\n", + "\n", + "\n", + "\n", + "\n", + "\n", + "Q01201_Q04206->STAT5A\n", + "\n", + "\n", + "\n", + "\n", + "\n", + "Q01201_Q04206->HNF4A\n", + "\n", + "\n", + "\n", + "\n", + "\n", + "\n", + "Q01201_Q04206->PPARG\n", + "\n", + "\n", + "\n", + "\n", + "\n", + "\n", + "P05412_P15408\n", + "\n", + "P05412_P15408\n", + "\n", + "\n", + "\n", + "P05412_P15408->SRC\n", + "\n", + "\n", + "\n", + "\n", + "\n", + "P05412_P15408->CDH1\n", + "\n", + "\n", + "\n", + "\n", + "\n", + "P05412_P15408->CDH2\n", + "\n", + "\n", + "\n", + "\n", + "\n", + "\n", + "P05412_P15408->PTK2B\n", + "\n", + "\n", + "\n", + "\n", + "\n", + "P05412_P15408->VIM\n", + "\n", + "\n", + "\n", + "\n", + "\n", + "P05412_P15408->NFKB1\n", + "\n", + "\n", + "\n", + "\n", + "\n", + "\n", + "P05412_P15408->SP1\n", + "\n", + "\n", + "\n", + "\n", + "\n", + "P05412_P15408->SP3\n", + "\n", + "\n", + "\n", + "\n", + "\n", + "P05412_P15408->PPARG\n", + "\n", + "\n", + "\n", + "\n", + "\n", + "\n", + "P17275_P17535\n", + "\n", + "P17275_P17535\n", + "\n", + "\n", + "\n", + "P17275_P17535->SRC\n", + "\n", + "\n", + "\n", + "\n", + "\n", + "P17275_P17535->CDH1\n", + "\n", + "\n", + "\n", + "\n", + "\n", + "P17275_P17535->CDH2\n", + "\n", + "\n", + "\n", + "\n", + "\n", + "\n", + "P17275_P17535->PTK2B\n", + "\n", + "\n", + "\n", + "\n", + "\n", + "P17275_P17535->VIM\n", + "\n", + "\n", + "\n", + "\n", + "\n", + "P17275_P17535->NFKB1\n", + "\n", + "\n", + "\n", + "\n", + "\n", + "\n", + "P17275_P17535->SP1\n", + "\n", + "\n", + "\n", + "\n", + "\n", + "P17275_P17535->SP3\n", + "\n", + "\n", + "\n", + "\n", + "\n", + "P17275_P17535->PPARG\n", + "\n", + "\n", + "\n", + "\n", + "\n", + "\n", + "MAP3K2->NFKB1\n", + "\n", + "\n", + "\n", + "\n", + "\n", + "MAP4K4\n", + "\n", + "MAP4K4\n", + "\n", + "\n", + "\n", + "MAP4K4->MAP3K2\n", + "\n", + "\n", + "\n", + "\n", + "\n", + "EPHB1->SRC\n", + "\n", + "\n", + "\n", + "\n", + "\n", + "EPHB1->PTK2\n", + "\n", + "\n", + "\n", + "\n", + "\n", + "\n", + "EPHB1->MAP4K4\n", + "\n", + "\n", + "\n", + "\n", + "\n", + "PPARG->CDH1\n", + "\n", + "\n", + "\n", + "\n", + "\n", + "PPARG->CDH2\n", + "\n", + "\n", + "\n", + "\n", + "\n", + "\n", + "PPARG->NFKB1\n", + "\n", + "\n", + "\n", + "\n", + "\n", + "\n", + "PPARG->SP1\n", + "\n", + "\n", + "\n", + "\n", + "\n", + "PPARG->STAT5A\n", + "\n", + "\n", + "\n", + "\n", + "\n", + "\n", + "PPARG->MAP4K4\n", + "\n", + "\n", + "\n", + "\n", + "\n", + "\n" + ], + "text/plain": [ + "" + ] + }, + "metadata": {}, + "output_type": "display_data" + } + ], + "source": [ + "visualizer = NetworkVisualizer(new_net1, color_by='effect')\n", + "visualizer.render()" + ] + }, + { + "cell_type": "markdown", + "id": "57cabbaa", + "metadata": {}, + "source": [ + "### We can access the network object edges to explore which interactions are in our network" + ] + }, + { + "cell_type": "markdown", + "id": "8361d2b2-646b-4080-bc36-ca28c9bfab10", + "metadata": {}, + "source": [ + "## The whole tool, as the name suggest, is based on Omnipath. But the user can also integrate its own databases. As example, we show how to integrate the Signor database. In order to do so, the User needs to have already downloaded the whole Signor database, available at the following link: https://signor.uniroma2.it/downloads.php \n", + "## Omniflow has been conceived to be a modular tool, with the possibility to add new databases. Every time a User wants to add a database, it should prepare an apposite function in the Resources module, in order to convert the target database, in the Omniflow format. We suggest to use as example, the function created for the Signor database. In future releases we plan to add more function to include more databases." + ] + }, + { + "cell_type": "code", + "execution_count": 16, + "id": "4fd4b190-350a-4682-8f09-8c6423064038", + "metadata": {}, + "outputs": [], + "source": [ + "resources = Resources()\n", + "resources.import_signor_tsv(\"./all_data_18_03_24.tsv\") # this function accept only tab separated values" + ] + }, + { + "cell_type": "code", + "execution_count": 23, + "id": "1ee6984a-1a6e-410e-b335-9acc1359b359", + "metadata": {}, + "outputs": [ + { + "name": "stdout", + "output_type": "stream", + "text": [ + "CPU times: user 32.3 ms, sys: 2 µs, total: 32.3 ms\n", + "Wall time: 31.6 ms\n" + ] + } + ], + "source": [ + "%%time\n", + "new_net1 = Network(genes, resources=resources.interactions) # here we load the signor interactions" + ] + }, + { + "cell_type": "markdown", + "id": "7aae5ca7-5696-44ba-9e75-4a2d1eb0a2d9", + "metadata": {}, + "source": [ + "## It is important to note, that not all the databases have the same structure as Omnipath. In particular, if the columns \"consensus\" are missing, we suggest to avoid to use the flag \"consensus\" or \"consensus_only\" when using Omniflow with customize databases." + ] + }, + { + "cell_type": "code", + "execution_count": 24, + "id": "12052b3b-854f-41a0-a762-20de5cbc7b35", + "metadata": {}, + "outputs": [ + { + "name": "stdout", + "output_type": "stream", + "text": [ + "looking for paths in the network with length: 0 for node FOXA1 and GRHL1\n", + "looking for paths in the network with length: 1 for node FOXA1 and GRHL1\n", + "looking for paths in the network with length: 2 for node FOXA1 and GRHL1\n", + "looking for paths in the network with length: 3 for node FOXA1 and GRHL1\n", + "looking for paths in the network with length: 4 for node FOXA1 and GRHL1\n", + "looking for paths in the network with length: 5 for node FOXA1 and GRHL1\n", + "looking for paths in the network with length: 6 for node FOXA1 and GRHL1\n", + "i_search = 3\n", + "Looking for paths with length: 0 for node FOXA1 and GRHL1\n", + "i_search = 3\n", + "Looking for paths with length: 1 for node FOXA1 and GRHL1\n", + "i_search = 3\n", + "Looking for paths with length: 2 for node FOXA1 and GRHL1\n", + "i_search = 3\n", + "Looking for paths with length: 3 for node FOXA1 and GRHL1\n", + "looking for paths in the network with length: 0 for node FOXA1 and GRHL3\n", + "looking for paths in the network with length: 1 for node FOXA1 and GRHL3\n", + "looking for paths in the network with length: 2 for node FOXA1 and GRHL3\n", + "looking for paths in the network with length: 3 for node FOXA1 and GRHL3\n", + "looking for paths in the network with length: 4 for node FOXA1 and GRHL3\n", + "looking for paths in the network with length: 5 for node FOXA1 and GRHL3\n", + "looking for paths in the network with length: 6 for node FOXA1 and GRHL3\n", + "i_search = 3\n", + "Looking for paths with length: 0 for node FOXA1 and GRHL3\n", + "i_search = 3\n", + "Looking for paths with length: 1 for node FOXA1 and GRHL3\n", + "i_search = 3\n", + "Looking for paths with length: 2 for node FOXA1 and GRHL3\n", + "i_search = 3\n", + "Looking for paths with length: 3 for node FOXA1 and GRHL3\n", + "looking for paths in the network with length: 0 for node FOXA1 and EHF\n", + "looking for paths in the network with length: 1 for node FOXA1 and EHF\n", + "looking for paths in the network with length: 2 for node FOXA1 and EHF\n", + "looking for paths in the network with length: 3 for node FOXA1 and EHF\n", + "looking for paths in the network with length: 4 for node FOXA1 and EHF\n", + "looking for paths in the network with length: 5 for node FOXA1 and EHF\n", + "looking for paths in the network with length: 6 for node FOXA1 and EHF\n", + "i_search = 3\n", + "Looking for paths with length: 0 for node FOXA1 and EHF\n", + "i_search = 3\n", + "Looking for paths with length: 1 for node FOXA1 and EHF\n", + "i_search = 3\n", + "Looking for paths with length: 2 for node FOXA1 and EHF\n", + "i_search = 3\n", + "Looking for paths with length: 3 for node FOXA1 and EHF\n", + "looking for paths in the network with length: 0 for node FOXA1 and KLF5\n", + "looking for paths in the network with length: 1 for node FOXA1 and KLF5\n", + "looking for paths in the network with length: 2 for node FOXA1 and KLF5\n", + "looking for paths in the network with length: 3 for node FOXA1 and KLF5\n", + "looking for paths in the network with length: 4 for node FOXA1 and KLF5\n", + "looking for paths in the network with length: 5 for node FOXA1 and KLF5\n", + "looking for paths in the network with length: 6 for node FOXA1 and KLF5\n", + "i_search = 3\n", + "Looking for paths with length: 0 for node FOXA1 and KLF5\n", + "i_search = 3\n", + "Looking for paths with length: 1 for node FOXA1 and KLF5\n", + "i_search = 3\n", + "Looking for paths with length: 2 for node FOXA1 and KLF5\n", + "i_search = 3\n", + "Looking for paths with length: 3 for node FOXA1 and KLF5\n", + "[['FOXA1', 'HSPA1A', 'NR3C1', 'KLF5'], ['FOXA1', 'AR', 'NR3C1', 'KLF5']]\n", + "P55317 P0DMV8\n", + "P0DMV8 P04150\n", + "P04150 Q13887\n", + "P55317 P10275\n", + "P10275 P04150\n", + "P04150 Q13887\n", + "P55317 P0DMV8\n", + "P55317 P10275\n", + "P17676 Q13887\n", + "P04150 Q13887\n", + "P04150 P17676\n", + "P0DMV8 P04150\n", + "P04150 P10275\n", + "P10275 P04150\n", + "looking for paths in the network with length: 0 for node FOXA1 and HOXA9\n", + "looking for paths in the network with length: 1 for node FOXA1 and HOXA9\n", + "looking for paths in the network with length: 2 for node FOXA1 and HOXA9\n", + "looking for paths in the network with length: 3 for node FOXA1 and HOXA9\n", + "looking for paths in the network with length: 4 for node FOXA1 and HOXA9\n", + "looking for paths in the network with length: 5 for node FOXA1 and HOXA9\n", + "looking for paths in the network with length: 6 for node FOXA1 and HOXA9\n", + "i_search = 3\n", + "Looking for paths with length: 0 for node FOXA1 and HOXA9\n", + "i_search = 3\n", + "Looking for paths with length: 1 for node FOXA1 and HOXA9\n", + "i_search = 3\n", + "Looking for paths with length: 2 for node FOXA1 and HOXA9\n", + "i_search = 3\n", + "Looking for paths with length: 3 for node FOXA1 and HOXA9\n", + "[['FOXA1', 'NFIB', 'EZH2', 'HOXA9']]\n", + "P55317 O00712\n", + "O00712 Q15910\n", + "Q15910 P31269\n", + "P55317 P0DMV8\n", + "P55317 P10275\n", + "P55317 O00712\n", + "P17676 Q13887\n", + "P04150 Q13887\n", + "Q15910 P31269\n", + "Q15910 P31260\n", + "O00712 P41161\n", + "P04150 P17676\n", + "P0DMV8 P04150\n", + "P04150 P10275\n", + "P10275 P04150\n", + "Q15910 P10275\n", + "O00712 Q15910\n", + "looking for paths in the network with length: 0 for node FOXA1 and HOXA10\n", + "looking for paths in the network with length: 1 for node FOXA1 and HOXA10\n", + "looking for paths in the network with length: 2 for node FOXA1 and HOXA10\n", + "looking for paths in the network with length: 3 for node FOXA1 and HOXA10\n", + "Found a path!\n", + "[['FOXA1', 'NFIB', 'EZH2', 'HOXA10']]\n", + "looking for paths in the network with length: 0 for node FOXA1 and ETV4\n", + "looking for paths in the network with length: 1 for node FOXA1 and ETV4\n", + "looking for paths in the network with length: 2 for node FOXA1 and ETV4\n", + "looking for paths in the network with length: 3 for node FOXA1 and ETV4\n", + "looking for paths in the network with length: 4 for node FOXA1 and ETV4\n", + "looking for paths in the network with length: 5 for node FOXA1 and ETV4\n", + "looking for paths in the network with length: 6 for node FOXA1 and ETV4\n", + "i_search = 3\n", + "Looking for paths with length: 0 for node FOXA1 and ETV4\n", + "i_search = 3\n", + "Looking for paths with length: 1 for node FOXA1 and ETV4\n", + "i_search = 3\n", + "Looking for paths with length: 2 for node FOXA1 and ETV4\n", + "i_search = 3\n", + "Looking for paths with length: 3 for node FOXA1 and ETV4\n", + "looking for paths in the network with length: 0 for node FOXA1 and ETV5\n", + "looking for paths in the network with length: 1 for node FOXA1 and ETV5\n", + "looking for paths in the network with length: 2 for node FOXA1 and ETV5\n", + "Found a path!\n", + "[['FOXA1', 'NFIB', 'ETV5']]\n", + "looking for paths in the network with length: 0 for node FOXA1 and POU3F1\n", + "looking for paths in the network with length: 1 for node FOXA1 and POU3F1\n", + "looking for paths in the network with length: 2 for node FOXA1 and POU3F1\n", + "looking for paths in the network with length: 3 for node FOXA1 and POU3F1\n", + "looking for paths in the network with length: 4 for node FOXA1 and POU3F1\n", + "looking for paths in the network with length: 5 for node FOXA1 and POU3F1\n", + "looking for paths in the network with length: 6 for node FOXA1 and POU3F1\n", + "i_search = 3\n", + "Looking for paths with length: 0 for node FOXA1 and POU3F1\n", + "i_search = 3\n", + "Looking for paths with length: 1 for node FOXA1 and POU3F1\n", + "i_search = 3\n", + "Looking for paths with length: 2 for node FOXA1 and POU3F1\n", + "i_search = 3\n", + "Looking for paths with length: 3 for node FOXA1 and POU3F1\n", + "looking for paths in the network with length: 0 for node FOXA1 and CEBPB\n", + "looking for paths in the network with length: 1 for node FOXA1 and CEBPB\n", + "looking for paths in the network with length: 2 for node FOXA1 and CEBPB\n", + "looking for paths in the network with length: 3 for node FOXA1 and CEBPB\n", + "Found a path!\n", + "[['FOXA1', 'HSPA1A', 'NR3C1', 'CEBPB'], ['FOXA1', 'AR', 'NR3C1', 'CEBPB']]\n", + "looking for paths in the network with length: 0 for node GRHL1 and GRHL3\n", + "looking for paths in the network with length: 1 for node GRHL1 and GRHL3\n", + "looking for paths in the network with length: 2 for node GRHL1 and GRHL3\n", + "looking for paths in the network with length: 3 for node GRHL1 and GRHL3\n", + "looking for paths in the network with length: 4 for node GRHL1 and GRHL3\n", + "looking for paths in the network with length: 5 for node GRHL1 and GRHL3\n", + "looking for paths in the network with length: 6 for node GRHL1 and GRHL3\n", + "i_search = 3\n", + "Looking for paths with length: 0 for node GRHL1 and GRHL3\n", + "i_search = 3\n", + "Looking for paths with length: 1 for node GRHL1 and GRHL3\n", + "i_search = 3\n", + "Looking for paths with length: 2 for node GRHL1 and GRHL3\n", + "i_search = 3\n", + "Looking for paths with length: 3 for node GRHL1 and GRHL3\n", + "looking for paths in the network with length: 0 for node GRHL1 and EHF\n", + "looking for paths in the network with length: 1 for node GRHL1 and EHF\n", + "looking for paths in the network with length: 2 for node GRHL1 and EHF\n", + "looking for paths in the network with length: 3 for node GRHL1 and EHF\n", + "looking for paths in the network with length: 4 for node GRHL1 and EHF\n", + "looking for paths in the network with length: 5 for node GRHL1 and EHF\n", + "looking for paths in the network with length: 6 for node GRHL1 and EHF\n", + "i_search = 3\n", + "Looking for paths with length: 0 for node GRHL1 and EHF\n", + "i_search = 3\n", + "Looking for paths with length: 1 for node GRHL1 and EHF\n", + "i_search = 3\n", + "Looking for paths with length: 2 for node GRHL1 and EHF\n", + "i_search = 3\n", + "Looking for paths with length: 3 for node GRHL1 and EHF\n", + "looking for paths in the network with length: 0 for node GRHL1 and KLF5\n", + "looking for paths in the network with length: 1 for node GRHL1 and KLF5\n", + "looking for paths in the network with length: 2 for node GRHL1 and KLF5\n", + "looking for paths in the network with length: 3 for node GRHL1 and KLF5\n", + "looking for paths in the network with length: 4 for node GRHL1 and KLF5\n", + "looking for paths in the network with length: 5 for node GRHL1 and KLF5\n", + "looking for paths in the network with length: 6 for node GRHL1 and KLF5\n", + "i_search = 3\n", + "Looking for paths with length: 0 for node GRHL1 and KLF5\n", + "i_search = 3\n", + "Looking for paths with length: 1 for node GRHL1 and KLF5\n", + "i_search = 3\n", + "Looking for paths with length: 2 for node GRHL1 and KLF5\n", + "i_search = 3\n", + "Looking for paths with length: 3 for node GRHL1 and KLF5\n", + "looking for paths in the network with length: 0 for node GRHL1 and HOXA9\n", + "looking for paths in the network with length: 1 for node GRHL1 and HOXA9\n", + "looking for paths in the network with length: 2 for node GRHL1 and HOXA9\n", + "looking for paths in the network with length: 3 for node GRHL1 and HOXA9\n", + "looking for paths in the network with length: 4 for node GRHL1 and HOXA9\n", + "looking for paths in the network with length: 5 for node GRHL1 and HOXA9\n", + "looking for paths in the network with length: 6 for node GRHL1 and HOXA9\n", + "i_search = 3\n", + "Looking for paths with length: 0 for node GRHL1 and HOXA9\n", + "i_search = 3\n", + "Looking for paths with length: 1 for node GRHL1 and HOXA9\n", + "i_search = 3\n", + "Looking for paths with length: 2 for node GRHL1 and HOXA9\n", + "i_search = 3\n", + "Looking for paths with length: 3 for node GRHL1 and HOXA9\n", + "looking for paths in the network with length: 0 for node GRHL1 and HOXA10\n", + "looking for paths in the network with length: 1 for node GRHL1 and HOXA10\n", + "looking for paths in the network with length: 2 for node GRHL1 and HOXA10\n", + "looking for paths in the network with length: 3 for node GRHL1 and HOXA10\n", + "looking for paths in the network with length: 4 for node GRHL1 and HOXA10\n", + "looking for paths in the network with length: 5 for node GRHL1 and HOXA10\n", + "looking for paths in the network with length: 6 for node GRHL1 and HOXA10\n", + "i_search = 3\n", + "Looking for paths with length: 0 for node GRHL1 and HOXA10\n", + "i_search = 3\n", + "Looking for paths with length: 1 for node GRHL1 and HOXA10\n", + "i_search = 3\n", + "Looking for paths with length: 2 for node GRHL1 and HOXA10\n", + "i_search = 3\n", + "Looking for paths with length: 3 for node GRHL1 and HOXA10\n", + "looking for paths in the network with length: 0 for node GRHL1 and ETV4\n", + "looking for paths in the network with length: 1 for node GRHL1 and ETV4\n", + "looking for paths in the network with length: 2 for node GRHL1 and ETV4\n", + "looking for paths in the network with length: 3 for node GRHL1 and ETV4\n", + "looking for paths in the network with length: 4 for node GRHL1 and ETV4\n", + "looking for paths in the network with length: 5 for node GRHL1 and ETV4\n", + "looking for paths in the network with length: 6 for node GRHL1 and ETV4\n", + "i_search = 3\n", + "Looking for paths with length: 0 for node GRHL1 and ETV4\n", + "i_search = 3\n", + "Looking for paths with length: 1 for node GRHL1 and ETV4\n", + "i_search = 3\n", + "Looking for paths with length: 2 for node GRHL1 and ETV4\n", + "i_search = 3\n", + "Looking for paths with length: 3 for node GRHL1 and ETV4\n", + "looking for paths in the network with length: 0 for node GRHL1 and ETV5\n", + "looking for paths in the network with length: 1 for node GRHL1 and ETV5\n", + "looking for paths in the network with length: 2 for node GRHL1 and ETV5\n", + "looking for paths in the network with length: 3 for node GRHL1 and ETV5\n", + "looking for paths in the network with length: 4 for node GRHL1 and ETV5\n", + "looking for paths in the network with length: 5 for node GRHL1 and ETV5\n", + "looking for paths in the network with length: 6 for node GRHL1 and ETV5\n", + "i_search = 3\n", + "Looking for paths with length: 0 for node GRHL1 and ETV5\n", + "i_search = 3\n", + "Looking for paths with length: 1 for node GRHL1 and ETV5\n", + "i_search = 3\n", + "Looking for paths with length: 2 for node GRHL1 and ETV5\n", + "i_search = 3\n", + "Looking for paths with length: 3 for node GRHL1 and ETV5\n", + "looking for paths in the network with length: 0 for node GRHL1 and POU3F1\n", + "looking for paths in the network with length: 1 for node GRHL1 and POU3F1\n", + "looking for paths in the network with length: 2 for node GRHL1 and POU3F1\n", + "looking for paths in the network with length: 3 for node GRHL1 and POU3F1\n", + "looking for paths in the network with length: 4 for node GRHL1 and POU3F1\n", + "looking for paths in the network with length: 5 for node GRHL1 and POU3F1\n", + "looking for paths in the network with length: 6 for node GRHL1 and POU3F1\n", + "i_search = 3\n", + "Looking for paths with length: 0 for node GRHL1 and POU3F1\n", + "i_search = 3\n", + "Looking for paths with length: 1 for node GRHL1 and POU3F1\n", + "i_search = 3\n", + "Looking for paths with length: 2 for node GRHL1 and POU3F1\n", + "i_search = 3\n", + "Looking for paths with length: 3 for node GRHL1 and POU3F1\n", + "looking for paths in the network with length: 0 for node GRHL1 and CEBPB\n", + "looking for paths in the network with length: 1 for node GRHL1 and CEBPB\n", + "looking for paths in the network with length: 2 for node GRHL1 and CEBPB\n", + "looking for paths in the network with length: 3 for node GRHL1 and CEBPB\n", + "looking for paths in the network with length: 4 for node GRHL1 and CEBPB\n", + "looking for paths in the network with length: 5 for node GRHL1 and CEBPB\n", + "looking for paths in the network with length: 6 for node GRHL1 and CEBPB\n", + "i_search = 3\n", + "Looking for paths with length: 0 for node GRHL1 and CEBPB\n", + "i_search = 3\n", + "Looking for paths with length: 1 for node GRHL1 and CEBPB\n", + "i_search = 3\n", + "Looking for paths with length: 2 for node GRHL1 and CEBPB\n", + "i_search = 3\n", + "Looking for paths with length: 3 for node GRHL1 and CEBPB\n", + "looking for paths in the network with length: 0 for node GRHL3 and EHF\n", + "looking for paths in the network with length: 1 for node GRHL3 and EHF\n", + "looking for paths in the network with length: 2 for node GRHL3 and EHF\n", + "looking for paths in the network with length: 3 for node GRHL3 and EHF\n", + "looking for paths in the network with length: 4 for node GRHL3 and EHF\n", + "looking for paths in the network with length: 5 for node GRHL3 and EHF\n", + "looking for paths in the network with length: 6 for node GRHL3 and EHF\n", + "i_search = 3\n", + "Looking for paths with length: 0 for node GRHL3 and EHF\n", + "i_search = 3\n", + "Looking for paths with length: 1 for node GRHL3 and EHF\n", + "i_search = 3\n", + "Looking for paths with length: 2 for node GRHL3 and EHF\n", + "i_search = 3\n", + "Looking for paths with length: 3 for node GRHL3 and EHF\n", + "looking for paths in the network with length: 0 for node GRHL3 and KLF5\n", + "looking for paths in the network with length: 1 for node GRHL3 and KLF5\n", + "looking for paths in the network with length: 2 for node GRHL3 and KLF5\n", + "looking for paths in the network with length: 3 for node GRHL3 and KLF5\n", + "looking for paths in the network with length: 4 for node GRHL3 and KLF5\n", + "looking for paths in the network with length: 5 for node GRHL3 and KLF5\n", + "looking for paths in the network with length: 6 for node GRHL3 and KLF5\n", + "i_search = 3\n", + "Looking for paths with length: 0 for node GRHL3 and KLF5\n", + "i_search = 3\n", + "Looking for paths with length: 1 for node GRHL3 and KLF5\n", + "i_search = 3\n", + "Looking for paths with length: 2 for node GRHL3 and KLF5\n", + "i_search = 3\n", + "Looking for paths with length: 3 for node GRHL3 and KLF5\n", + "looking for paths in the network with length: 0 for node GRHL3 and HOXA9\n", + "looking for paths in the network with length: 1 for node GRHL3 and HOXA9\n", + "looking for paths in the network with length: 2 for node GRHL3 and HOXA9\n", + "looking for paths in the network with length: 3 for node GRHL3 and HOXA9\n", + "looking for paths in the network with length: 4 for node GRHL3 and HOXA9\n", + "looking for paths in the network with length: 5 for node GRHL3 and HOXA9\n", + "looking for paths in the network with length: 6 for node GRHL3 and HOXA9\n", + "i_search = 3\n", + "Looking for paths with length: 0 for node GRHL3 and HOXA9\n", + "i_search = 3\n", + "Looking for paths with length: 1 for node GRHL3 and HOXA9\n", + "i_search = 3\n", + "Looking for paths with length: 2 for node GRHL3 and HOXA9\n", + "i_search = 3\n", + "Looking for paths with length: 3 for node GRHL3 and HOXA9\n", + "looking for paths in the network with length: 0 for node GRHL3 and HOXA10\n", + "looking for paths in the network with length: 1 for node GRHL3 and HOXA10\n", + "looking for paths in the network with length: 2 for node GRHL3 and HOXA10\n", + "looking for paths in the network with length: 3 for node GRHL3 and HOXA10\n", + "looking for paths in the network with length: 4 for node GRHL3 and HOXA10\n", + "looking for paths in the network with length: 5 for node GRHL3 and HOXA10\n", + "looking for paths in the network with length: 6 for node GRHL3 and HOXA10\n", + "i_search = 3\n", + "Looking for paths with length: 0 for node GRHL3 and HOXA10\n", + "i_search = 3\n", + "Looking for paths with length: 1 for node GRHL3 and HOXA10\n", + "i_search = 3\n", + "Looking for paths with length: 2 for node GRHL3 and HOXA10\n", + "i_search = 3\n", + "Looking for paths with length: 3 for node GRHL3 and HOXA10\n", + "looking for paths in the network with length: 0 for node GRHL3 and ETV4\n", + "looking for paths in the network with length: 1 for node GRHL3 and ETV4\n", + "looking for paths in the network with length: 2 for node GRHL3 and ETV4\n", + "looking for paths in the network with length: 3 for node GRHL3 and ETV4\n", + "looking for paths in the network with length: 4 for node GRHL3 and ETV4\n", + "looking for paths in the network with length: 5 for node GRHL3 and ETV4\n", + "looking for paths in the network with length: 6 for node GRHL3 and ETV4\n", + "i_search = 3\n", + "Looking for paths with length: 0 for node GRHL3 and ETV4\n", + "i_search = 3\n", + "Looking for paths with length: 1 for node GRHL3 and ETV4\n", + "i_search = 3\n", + "Looking for paths with length: 2 for node GRHL3 and ETV4\n", + "i_search = 3\n", + "Looking for paths with length: 3 for node GRHL3 and ETV4\n", + "looking for paths in the network with length: 0 for node GRHL3 and ETV5\n", + "looking for paths in the network with length: 1 for node GRHL3 and ETV5\n", + "looking for paths in the network with length: 2 for node GRHL3 and ETV5\n", + "looking for paths in the network with length: 3 for node GRHL3 and ETV5\n", + "looking for paths in the network with length: 4 for node GRHL3 and ETV5\n", + "looking for paths in the network with length: 5 for node GRHL3 and ETV5\n", + "looking for paths in the network with length: 6 for node GRHL3 and ETV5\n", + "i_search = 3\n", + "Looking for paths with length: 0 for node GRHL3 and ETV5\n", + "i_search = 3\n", + "Looking for paths with length: 1 for node GRHL3 and ETV5\n", + "i_search = 3\n", + "Looking for paths with length: 2 for node GRHL3 and ETV5\n", + "i_search = 3\n", + "Looking for paths with length: 3 for node GRHL3 and ETV5\n", + "looking for paths in the network with length: 0 for node GRHL3 and POU3F1\n", + "looking for paths in the network with length: 1 for node GRHL3 and POU3F1\n", + "looking for paths in the network with length: 2 for node GRHL3 and POU3F1\n", + "looking for paths in the network with length: 3 for node GRHL3 and POU3F1\n", + "looking for paths in the network with length: 4 for node GRHL3 and POU3F1\n", + "looking for paths in the network with length: 5 for node GRHL3 and POU3F1\n", + "looking for paths in the network with length: 6 for node GRHL3 and POU3F1\n", + "i_search = 3\n", + "Looking for paths with length: 0 for node GRHL3 and POU3F1\n", + "i_search = 3\n", + "Looking for paths with length: 1 for node GRHL3 and POU3F1\n", + "i_search = 3\n", + "Looking for paths with length: 2 for node GRHL3 and POU3F1\n", + "i_search = 3\n", + "Looking for paths with length: 3 for node GRHL3 and POU3F1\n", + "looking for paths in the network with length: 0 for node GRHL3 and CEBPB\n", + "looking for paths in the network with length: 1 for node GRHL3 and CEBPB\n", + "looking for paths in the network with length: 2 for node GRHL3 and CEBPB\n", + "looking for paths in the network with length: 3 for node GRHL3 and CEBPB\n", + "looking for paths in the network with length: 4 for node GRHL3 and CEBPB\n", + "looking for paths in the network with length: 5 for node GRHL3 and CEBPB\n", + "looking for paths in the network with length: 6 for node GRHL3 and CEBPB\n", + "i_search = 3\n", + "Looking for paths with length: 0 for node GRHL3 and CEBPB\n", + "i_search = 3\n", + "Looking for paths with length: 1 for node GRHL3 and CEBPB\n", + "i_search = 3\n", + "Looking for paths with length: 2 for node GRHL3 and CEBPB\n", + "i_search = 3\n", + "Looking for paths with length: 3 for node GRHL3 and CEBPB\n", + "looking for paths in the network with length: 0 for node EHF and KLF5\n", + "looking for paths in the network with length: 1 for node EHF and KLF5\n", + "looking for paths in the network with length: 2 for node EHF and KLF5\n", + "looking for paths in the network with length: 3 for node EHF and KLF5\n", + "looking for paths in the network with length: 4 for node EHF and KLF5\n", + "looking for paths in the network with length: 5 for node EHF and KLF5\n", + "looking for paths in the network with length: 6 for node EHF and KLF5\n", + "i_search = 3\n", + "Looking for paths with length: 0 for node EHF and KLF5\n", + "i_search = 3\n", + "Looking for paths with length: 1 for node EHF and KLF5\n", + "i_search = 3\n", + "Looking for paths with length: 2 for node EHF and KLF5\n", + "i_search = 3\n", + "Looking for paths with length: 3 for node EHF and KLF5\n", + "looking for paths in the network with length: 0 for node EHF and HOXA9\n", + "looking for paths in the network with length: 1 for node EHF and HOXA9\n", + "looking for paths in the network with length: 2 for node EHF and HOXA9\n", + "looking for paths in the network with length: 3 for node EHF and HOXA9\n", + "looking for paths in the network with length: 4 for node EHF and HOXA9\n", + "looking for paths in the network with length: 5 for node EHF and HOXA9\n", + "looking for paths in the network with length: 6 for node EHF and HOXA9\n", + "i_search = 3\n", + "Looking for paths with length: 0 for node EHF and HOXA9\n", + "i_search = 3\n", + "Looking for paths with length: 1 for node EHF and HOXA9\n", + "i_search = 3\n", + "Looking for paths with length: 2 for node EHF and HOXA9\n", + "i_search = 3\n", + "Looking for paths with length: 3 for node EHF and HOXA9\n", + "looking for paths in the network with length: 0 for node EHF and HOXA10\n", + "looking for paths in the network with length: 1 for node EHF and HOXA10\n", + "looking for paths in the network with length: 2 for node EHF and HOXA10\n", + "looking for paths in the network with length: 3 for node EHF and HOXA10\n", + "looking for paths in the network with length: 4 for node EHF and HOXA10\n", + "looking for paths in the network with length: 5 for node EHF and HOXA10\n", + "looking for paths in the network with length: 6 for node EHF and HOXA10\n", + "i_search = 3\n", + "Looking for paths with length: 0 for node EHF and HOXA10\n", + "i_search = 3\n", + "Looking for paths with length: 1 for node EHF and HOXA10\n", + "i_search = 3\n", + "Looking for paths with length: 2 for node EHF and HOXA10\n", + "i_search = 3\n", + "Looking for paths with length: 3 for node EHF and HOXA10\n", + "looking for paths in the network with length: 0 for node EHF and ETV4\n", + "looking for paths in the network with length: 1 for node EHF and ETV4\n", + "looking for paths in the network with length: 2 for node EHF and ETV4\n", + "looking for paths in the network with length: 3 for node EHF and ETV4\n", + "looking for paths in the network with length: 4 for node EHF and ETV4\n", + "looking for paths in the network with length: 5 for node EHF and ETV4\n", + "looking for paths in the network with length: 6 for node EHF and ETV4\n", + "i_search = 3\n", + "Looking for paths with length: 0 for node EHF and ETV4\n", + "i_search = 3\n", + "Looking for paths with length: 1 for node EHF and ETV4\n", + "i_search = 3\n", + "Looking for paths with length: 2 for node EHF and ETV4\n", + "i_search = 3\n", + "Looking for paths with length: 3 for node EHF and ETV4\n", + "looking for paths in the network with length: 0 for node EHF and ETV5\n", + "looking for paths in the network with length: 1 for node EHF and ETV5\n", + "looking for paths in the network with length: 2 for node EHF and ETV5\n", + "looking for paths in the network with length: 3 for node EHF and ETV5\n", + "looking for paths in the network with length: 4 for node EHF and ETV5\n", + "looking for paths in the network with length: 5 for node EHF and ETV5\n", + "looking for paths in the network with length: 6 for node EHF and ETV5\n", + "i_search = 3\n", + "Looking for paths with length: 0 for node EHF and ETV5\n", + "i_search = 3\n", + "Looking for paths with length: 1 for node EHF and ETV5\n", + "i_search = 3\n", + "Looking for paths with length: 2 for node EHF and ETV5\n", + "i_search = 3\n", + "Looking for paths with length: 3 for node EHF and ETV5\n", + "looking for paths in the network with length: 0 for node EHF and POU3F1\n", + "looking for paths in the network with length: 1 for node EHF and POU3F1\n", + "looking for paths in the network with length: 2 for node EHF and POU3F1\n", + "looking for paths in the network with length: 3 for node EHF and POU3F1\n", + "looking for paths in the network with length: 4 for node EHF and POU3F1\n", + "looking for paths in the network with length: 5 for node EHF and POU3F1\n", + "looking for paths in the network with length: 6 for node EHF and POU3F1\n", + "i_search = 3\n", + "Looking for paths with length: 0 for node EHF and POU3F1\n", + "i_search = 3\n", + "Looking for paths with length: 1 for node EHF and POU3F1\n", + "i_search = 3\n", + "Looking for paths with length: 2 for node EHF and POU3F1\n", + "i_search = 3\n", + "Looking for paths with length: 3 for node EHF and POU3F1\n", + "looking for paths in the network with length: 0 for node EHF and CEBPB\n", + "looking for paths in the network with length: 1 for node EHF and CEBPB\n", + "looking for paths in the network with length: 2 for node EHF and CEBPB\n", + "looking for paths in the network with length: 3 for node EHF and CEBPB\n", + "looking for paths in the network with length: 4 for node EHF and CEBPB\n", + "looking for paths in the network with length: 5 for node EHF and CEBPB\n", + "looking for paths in the network with length: 6 for node EHF and CEBPB\n", + "i_search = 3\n", + "Looking for paths with length: 0 for node EHF and CEBPB\n", + "i_search = 3\n", + "Looking for paths with length: 1 for node EHF and CEBPB\n", + "i_search = 3\n", + "Looking for paths with length: 2 for node EHF and CEBPB\n", + "i_search = 3\n", + "Looking for paths with length: 3 for node EHF and CEBPB\n", + "looking for paths in the network with length: 0 for node KLF5 and HOXA9\n", + "looking for paths in the network with length: 1 for node KLF5 and HOXA9\n", + "looking for paths in the network with length: 2 for node KLF5 and HOXA9\n", + "looking for paths in the network with length: 3 for node KLF5 and HOXA9\n", + "looking for paths in the network with length: 4 for node KLF5 and HOXA9\n", + "looking for paths in the network with length: 5 for node KLF5 and HOXA9\n", + "looking for paths in the network with length: 6 for node KLF5 and HOXA9\n", + "i_search = 3\n", + "Looking for paths with length: 0 for node KLF5 and HOXA9\n", + "i_search = 3\n", + "Looking for paths with length: 1 for node KLF5 and HOXA9\n", + "i_search = 3\n", + "Looking for paths with length: 2 for node KLF5 and HOXA9\n", + "i_search = 3\n", + "Looking for paths with length: 3 for node KLF5 and HOXA9\n", + "looking for paths in the network with length: 0 for node KLF5 and HOXA10\n", + "looking for paths in the network with length: 1 for node KLF5 and HOXA10\n", + "looking for paths in the network with length: 2 for node KLF5 and HOXA10\n", + "looking for paths in the network with length: 3 for node KLF5 and HOXA10\n", + "looking for paths in the network with length: 4 for node KLF5 and HOXA10\n", + "looking for paths in the network with length: 5 for node KLF5 and HOXA10\n", + "looking for paths in the network with length: 6 for node KLF5 and HOXA10\n", + "i_search = 3\n", + "Looking for paths with length: 0 for node KLF5 and HOXA10\n", + "i_search = 3\n", + "Looking for paths with length: 1 for node KLF5 and HOXA10\n", + "i_search = 3\n", + "Looking for paths with length: 2 for node KLF5 and HOXA10\n", + "i_search = 3\n", + "Looking for paths with length: 3 for node KLF5 and HOXA10\n", + "looking for paths in the network with length: 0 for node KLF5 and ETV4\n", + "looking for paths in the network with length: 1 for node KLF5 and ETV4\n", + "looking for paths in the network with length: 2 for node KLF5 and ETV4\n", + "looking for paths in the network with length: 3 for node KLF5 and ETV4\n", + "looking for paths in the network with length: 4 for node KLF5 and ETV4\n", + "looking for paths in the network with length: 5 for node KLF5 and ETV4\n", + "looking for paths in the network with length: 6 for node KLF5 and ETV4\n", + "i_search = 3\n", + "Looking for paths with length: 0 for node KLF5 and ETV4\n", + "i_search = 3\n", + "Looking for paths with length: 1 for node KLF5 and ETV4\n", + "i_search = 3\n", + "Looking for paths with length: 2 for node KLF5 and ETV4\n", + "i_search = 3\n", + "Looking for paths with length: 3 for node KLF5 and ETV4\n", + "looking for paths in the network with length: 0 for node KLF5 and ETV5\n", + "looking for paths in the network with length: 1 for node KLF5 and ETV5\n", + "looking for paths in the network with length: 2 for node KLF5 and ETV5\n", + "looking for paths in the network with length: 3 for node KLF5 and ETV5\n", + "looking for paths in the network with length: 4 for node KLF5 and ETV5\n", + "looking for paths in the network with length: 5 for node KLF5 and ETV5\n", + "looking for paths in the network with length: 6 for node KLF5 and ETV5\n", + "i_search = 3\n", + "Looking for paths with length: 0 for node KLF5 and ETV5\n", + "i_search = 3\n", + "Looking for paths with length: 1 for node KLF5 and ETV5\n", + "i_search = 3\n", + "Looking for paths with length: 2 for node KLF5 and ETV5\n", + "i_search = 3\n", + "Looking for paths with length: 3 for node KLF5 and ETV5\n", + "looking for paths in the network with length: 0 for node KLF5 and POU3F1\n", + "looking for paths in the network with length: 1 for node KLF5 and POU3F1\n", + "looking for paths in the network with length: 2 for node KLF5 and POU3F1\n", + "looking for paths in the network with length: 3 for node KLF5 and POU3F1\n", + "looking for paths in the network with length: 4 for node KLF5 and POU3F1\n", + "looking for paths in the network with length: 5 for node KLF5 and POU3F1\n", + "looking for paths in the network with length: 6 for node KLF5 and POU3F1\n", + "i_search = 3\n", + "Looking for paths with length: 0 for node KLF5 and POU3F1\n", + "i_search = 3\n", + "Looking for paths with length: 1 for node KLF5 and POU3F1\n", + "i_search = 3\n", + "Looking for paths with length: 2 for node KLF5 and POU3F1\n", + "i_search = 3\n", + "Looking for paths with length: 3 for node KLF5 and POU3F1\n", + "looking for paths in the network with length: 0 for node KLF5 and CEBPB\n", + "looking for paths in the network with length: 1 for node KLF5 and CEBPB\n", + "Found a path!\n", + "[['KLF5', 'CEBPB']]\n", + "looking for paths in the network with length: 0 for node HOXA9 and HOXA10\n", + "looking for paths in the network with length: 1 for node HOXA9 and HOXA10\n", + "looking for paths in the network with length: 2 for node HOXA9 and HOXA10\n", + "looking for paths in the network with length: 3 for node HOXA9 and HOXA10\n", + "looking for paths in the network with length: 4 for node HOXA9 and HOXA10\n", + "looking for paths in the network with length: 5 for node HOXA9 and HOXA10\n", + "looking for paths in the network with length: 6 for node HOXA9 and HOXA10\n", + "i_search = 3\n", + "Looking for paths with length: 0 for node HOXA9 and HOXA10\n", + "i_search = 3\n", + "Looking for paths with length: 1 for node HOXA9 and HOXA10\n", + "i_search = 3\n", + "Looking for paths with length: 2 for node HOXA9 and HOXA10\n", + "i_search = 3\n", + "Looking for paths with length: 3 for node HOXA9 and HOXA10\n", + "looking for paths in the network with length: 0 for node HOXA9 and ETV4\n", + "looking for paths in the network with length: 1 for node HOXA9 and ETV4\n", + "looking for paths in the network with length: 2 for node HOXA9 and ETV4\n", + "looking for paths in the network with length: 3 for node HOXA9 and ETV4\n", + "looking for paths in the network with length: 4 for node HOXA9 and ETV4\n", + "looking for paths in the network with length: 5 for node HOXA9 and ETV4\n", + "looking for paths in the network with length: 6 for node HOXA9 and ETV4\n", + "i_search = 3\n", + "Looking for paths with length: 0 for node HOXA9 and ETV4\n", + "i_search = 3\n", + "Looking for paths with length: 1 for node HOXA9 and ETV4\n", + "i_search = 3\n", + "Looking for paths with length: 2 for node HOXA9 and ETV4\n", + "i_search = 3\n", + "Looking for paths with length: 3 for node HOXA9 and ETV4\n", + "looking for paths in the network with length: 0 for node HOXA9 and ETV5\n", + "looking for paths in the network with length: 1 for node HOXA9 and ETV5\n", + "looking for paths in the network with length: 2 for node HOXA9 and ETV5\n", + "looking for paths in the network with length: 3 for node HOXA9 and ETV5\n", + "looking for paths in the network with length: 4 for node HOXA9 and ETV5\n", + "looking for paths in the network with length: 5 for node HOXA9 and ETV5\n", + "looking for paths in the network with length: 6 for node HOXA9 and ETV5\n", + "i_search = 3\n", + "Looking for paths with length: 0 for node HOXA9 and ETV5\n", + "i_search = 3\n", + "Looking for paths with length: 1 for node HOXA9 and ETV5\n", + "i_search = 3\n", + "Looking for paths with length: 2 for node HOXA9 and ETV5\n", + "i_search = 3\n", + "Looking for paths with length: 3 for node HOXA9 and ETV5\n", + "looking for paths in the network with length: 0 for node HOXA9 and POU3F1\n", + "looking for paths in the network with length: 1 for node HOXA9 and POU3F1\n", + "looking for paths in the network with length: 2 for node HOXA9 and POU3F1\n", + "looking for paths in the network with length: 3 for node HOXA9 and POU3F1\n", + "looking for paths in the network with length: 4 for node HOXA9 and POU3F1\n", + "looking for paths in the network with length: 5 for node HOXA9 and POU3F1\n", + "looking for paths in the network with length: 6 for node HOXA9 and POU3F1\n", + "i_search = 3\n", + "Looking for paths with length: 0 for node HOXA9 and POU3F1\n", + "i_search = 3\n", + "Looking for paths with length: 1 for node HOXA9 and POU3F1\n", + "i_search = 3\n", + "Looking for paths with length: 2 for node HOXA9 and POU3F1\n", + "i_search = 3\n", + "Looking for paths with length: 3 for node HOXA9 and POU3F1\n", + "looking for paths in the network with length: 0 for node HOXA9 and CEBPB\n", + "looking for paths in the network with length: 1 for node HOXA9 and CEBPB\n", + "looking for paths in the network with length: 2 for node HOXA9 and CEBPB\n", + "looking for paths in the network with length: 3 for node HOXA9 and CEBPB\n", + "looking for paths in the network with length: 4 for node HOXA9 and CEBPB\n", + "looking for paths in the network with length: 5 for node HOXA9 and CEBPB\n", + "looking for paths in the network with length: 6 for node HOXA9 and CEBPB\n", + "i_search = 3\n", + "Looking for paths with length: 0 for node HOXA9 and CEBPB\n", + "i_search = 3\n", + "Looking for paths with length: 1 for node HOXA9 and CEBPB\n", + "i_search = 3\n", + "Looking for paths with length: 2 for node HOXA9 and CEBPB\n", + "i_search = 3\n", + "Looking for paths with length: 3 for node HOXA9 and CEBPB\n", + "[['HOXA9', 'PIM1', 'FLT3', 'CEBPB']]\n", + "P31269 P11309\n", + "P11309 P36888\n", + "P36888 P17676\n", + "P55317 P0DMV8\n", + "P55317 P10275\n", + "P55317 O00712\n", + "P17676 Q13887\n", + "P04150 Q13887\n", + "Q15910 P31269\n", + "P31269 P11309\n", + "Q15910 P31260\n", + "O00712 P41161\n", + "P04150 P17676\n", + "P36888 P17676\n", + "P0DMV8 P04150\n", + "P04150 P10275\n", + "P10275 P04150\n", + "Q15910 P10275\n", + "O00712 Q15910\n", + "P11309 P36888\n", + "P36888 P11309\n", + "looking for paths in the network with length: 0 for node HOXA10 and ETV4\n", + "looking for paths in the network with length: 1 for node HOXA10 and ETV4\n", + "looking for paths in the network with length: 2 for node HOXA10 and ETV4\n", + "looking for paths in the network with length: 3 for node HOXA10 and ETV4\n", + "looking for paths in the network with length: 4 for node HOXA10 and ETV4\n", + "looking for paths in the network with length: 5 for node HOXA10 and ETV4\n", + "looking for paths in the network with length: 6 for node HOXA10 and ETV4\n", + "i_search = 3\n", + "Looking for paths with length: 0 for node HOXA10 and ETV4\n", + "i_search = 3\n", + "Looking for paths with length: 1 for node HOXA10 and ETV4\n", + "i_search = 3\n", + "Looking for paths with length: 2 for node HOXA10 and ETV4\n", + "i_search = 3\n", + "Looking for paths with length: 3 for node HOXA10 and ETV4\n", + "looking for paths in the network with length: 0 for node HOXA10 and ETV5\n", + "looking for paths in the network with length: 1 for node HOXA10 and ETV5\n", + "looking for paths in the network with length: 2 for node HOXA10 and ETV5\n", + "looking for paths in the network with length: 3 for node HOXA10 and ETV5\n", + "looking for paths in the network with length: 4 for node HOXA10 and ETV5\n", + "looking for paths in the network with length: 5 for node HOXA10 and ETV5\n", + "looking for paths in the network with length: 6 for node HOXA10 and ETV5\n", + "i_search = 3\n", + "Looking for paths with length: 0 for node HOXA10 and ETV5\n", + "i_search = 3\n", + "Looking for paths with length: 1 for node HOXA10 and ETV5\n", + "i_search = 3\n", + "Looking for paths with length: 2 for node HOXA10 and ETV5\n", + "i_search = 3\n", + "Looking for paths with length: 3 for node HOXA10 and ETV5\n", + "looking for paths in the network with length: 0 for node HOXA10 and POU3F1\n", + "looking for paths in the network with length: 1 for node HOXA10 and POU3F1\n", + "looking for paths in the network with length: 2 for node HOXA10 and POU3F1\n", + "looking for paths in the network with length: 3 for node HOXA10 and POU3F1\n", + "looking for paths in the network with length: 4 for node HOXA10 and POU3F1\n", + "looking for paths in the network with length: 5 for node HOXA10 and POU3F1\n", + "looking for paths in the network with length: 6 for node HOXA10 and POU3F1\n", + "i_search = 3\n", + "Looking for paths with length: 0 for node HOXA10 and POU3F1\n", + "i_search = 3\n", + "Looking for paths with length: 1 for node HOXA10 and POU3F1\n", + "i_search = 3\n", + "Looking for paths with length: 2 for node HOXA10 and POU3F1\n", + "i_search = 3\n", + "Looking for paths with length: 3 for node HOXA10 and POU3F1\n", + "looking for paths in the network with length: 0 for node HOXA10 and CEBPB\n", + "looking for paths in the network with length: 1 for node HOXA10 and CEBPB\n", + "looking for paths in the network with length: 2 for node HOXA10 and CEBPB\n", + "looking for paths in the network with length: 3 for node HOXA10 and CEBPB\n", + "looking for paths in the network with length: 4 for node HOXA10 and CEBPB\n", + "looking for paths in the network with length: 5 for node HOXA10 and CEBPB\n", + "looking for paths in the network with length: 6 for node HOXA10 and CEBPB\n", + "i_search = 3\n", + "Looking for paths with length: 0 for node HOXA10 and CEBPB\n", + "i_search = 3\n", + "Looking for paths with length: 1 for node HOXA10 and CEBPB\n", + "i_search = 3\n", + "Looking for paths with length: 2 for node HOXA10 and CEBPB\n", + "i_search = 3\n", + "Looking for paths with length: 3 for node HOXA10 and CEBPB\n", + "looking for paths in the network with length: 0 for node ETV4 and ETV5\n", + "looking for paths in the network with length: 1 for node ETV4 and ETV5\n", + "looking for paths in the network with length: 2 for node ETV4 and ETV5\n", + "looking for paths in the network with length: 3 for node ETV4 and ETV5\n", + "looking for paths in the network with length: 4 for node ETV4 and ETV5\n", + "looking for paths in the network with length: 5 for node ETV4 and ETV5\n", + "looking for paths in the network with length: 6 for node ETV4 and ETV5\n", + "i_search = 3\n", + "Looking for paths with length: 0 for node ETV4 and ETV5\n", + "i_search = 3\n", + "Looking for paths with length: 1 for node ETV4 and ETV5\n", + "i_search = 3\n", + "Looking for paths with length: 2 for node ETV4 and ETV5\n", + "i_search = 3\n", + "Looking for paths with length: 3 for node ETV4 and ETV5\n", + "looking for paths in the network with length: 0 for node ETV4 and POU3F1\n", + "looking for paths in the network with length: 1 for node ETV4 and POU3F1\n", + "looking for paths in the network with length: 2 for node ETV4 and POU3F1\n", + "looking for paths in the network with length: 3 for node ETV4 and POU3F1\n", + "looking for paths in the network with length: 4 for node ETV4 and POU3F1\n", + "looking for paths in the network with length: 5 for node ETV4 and POU3F1\n", + "looking for paths in the network with length: 6 for node ETV4 and POU3F1\n", + "i_search = 3\n", + "Looking for paths with length: 0 for node ETV4 and POU3F1\n", + "i_search = 3\n", + "Looking for paths with length: 1 for node ETV4 and POU3F1\n", + "i_search = 3\n", + "Looking for paths with length: 2 for node ETV4 and POU3F1\n", + "i_search = 3\n", + "Looking for paths with length: 3 for node ETV4 and POU3F1\n", + "looking for paths in the network with length: 0 for node ETV4 and CEBPB\n", + "looking for paths in the network with length: 1 for node ETV4 and CEBPB\n", + "looking for paths in the network with length: 2 for node ETV4 and CEBPB\n", + "looking for paths in the network with length: 3 for node ETV4 and CEBPB\n", + "looking for paths in the network with length: 4 for node ETV4 and CEBPB\n", + "looking for paths in the network with length: 5 for node ETV4 and CEBPB\n", + "looking for paths in the network with length: 6 for node ETV4 and CEBPB\n", + "i_search = 3\n", + "Looking for paths with length: 0 for node ETV4 and CEBPB\n", + "i_search = 3\n", + "Looking for paths with length: 1 for node ETV4 and CEBPB\n", + "i_search = 3\n", + "Looking for paths with length: 2 for node ETV4 and CEBPB\n", + "i_search = 3\n", + "Looking for paths with length: 3 for node ETV4 and CEBPB\n", + "looking for paths in the network with length: 0 for node ETV5 and POU3F1\n", + "looking for paths in the network with length: 1 for node ETV5 and POU3F1\n", + "looking for paths in the network with length: 2 for node ETV5 and POU3F1\n", + "looking for paths in the network with length: 3 for node ETV5 and POU3F1\n", + "looking for paths in the network with length: 4 for node ETV5 and POU3F1\n", + "looking for paths in the network with length: 5 for node ETV5 and POU3F1\n", + "looking for paths in the network with length: 6 for node ETV5 and POU3F1\n", + "i_search = 3\n", + "Looking for paths with length: 0 for node ETV5 and POU3F1\n", + "i_search = 3\n", + "Looking for paths with length: 1 for node ETV5 and POU3F1\n", + "i_search = 3\n", + "Looking for paths with length: 2 for node ETV5 and POU3F1\n", + "i_search = 3\n", + "Looking for paths with length: 3 for node ETV5 and POU3F1\n", + "looking for paths in the network with length: 0 for node ETV5 and CEBPB\n", + "looking for paths in the network with length: 1 for node ETV5 and CEBPB\n", + "looking for paths in the network with length: 2 for node ETV5 and CEBPB\n", + "looking for paths in the network with length: 3 for node ETV5 and CEBPB\n", + "looking for paths in the network with length: 4 for node ETV5 and CEBPB\n", + "looking for paths in the network with length: 5 for node ETV5 and CEBPB\n", + "looking for paths in the network with length: 6 for node ETV5 and CEBPB\n", + "i_search = 3\n", + "Looking for paths with length: 0 for node ETV5 and CEBPB\n", + "i_search = 3\n", + "Looking for paths with length: 1 for node ETV5 and CEBPB\n", + "i_search = 3\n", + "Looking for paths with length: 2 for node ETV5 and CEBPB\n", + "i_search = 3\n", + "Looking for paths with length: 3 for node ETV5 and CEBPB\n", + "looking for paths in the network with length: 0 for node POU3F1 and CEBPB\n", + "looking for paths in the network with length: 1 for node POU3F1 and CEBPB\n", + "looking for paths in the network with length: 2 for node POU3F1 and CEBPB\n", + "looking for paths in the network with length: 3 for node POU3F1 and CEBPB\n", + "looking for paths in the network with length: 4 for node POU3F1 and CEBPB\n", + "looking for paths in the network with length: 5 for node POU3F1 and CEBPB\n", + "looking for paths in the network with length: 6 for node POU3F1 and CEBPB\n", + "i_search = 3\n", + "Looking for paths with length: 0 for node POU3F1 and CEBPB\n", + "i_search = 3\n", + "Looking for paths with length: 1 for node POU3F1 and CEBPB\n", + "i_search = 3\n", + "Looking for paths with length: 2 for node POU3F1 and CEBPB\n", + "i_search = 3\n", + "Looking for paths with length: 3 for node POU3F1 and CEBPB\n", + "CPU times: user 8.91 s, sys: 36 ms, total: 8.95 s\n", + "Wall time: 8.91 s\n" + ] + } + ], + "source": [ + "%%time\n", + "new_net1.complete_connection(mode=\"ALL\", maxlen=6, k_mean=\"tight\", only_signed=True,\n", + " connect_node_when_first_introduced=True) # here, consensus_only is missing, in this way it is automatically False" + ] + }, + { + "cell_type": "markdown", + "id": "64b445e7-2e45-40ee-9ee9-268965b4d55b", + "metadata": {}, + "source": [ + "## SIGNOR uses has different identifiers for complexes, protein family, phenotype, etc.\n", + "## It is possible that the network contains nodes names like \"Signor_pf32\" or something like this... This is not yet translated, but if you are interested in what those nodes consist of, you can use download their vocabulary for the entities: https://signor.uniroma2.it/downloads.php\n", + "## Maybe we are going to integrate this too... " + ] + }, + { + "cell_type": "markdown", + "id": "6b54c437", + "metadata": {}, + "source": [ + "### Finally we can export the network in bnet format with some basic logical equations or in sif format for Cytoscape visualization" + ] + }, + { + "cell_type": "code", + "execution_count": 13, + "id": "547e4090", + "metadata": {}, + "outputs": [], + "source": [ + "from omniflow_project._outputs.exports import Exports" + ] + }, + { + "cell_type": "code", + "execution_count": 14, + "id": "6fd81835", + "metadata": {}, + "outputs": [], + "source": [ + "export = Exports(new_net1)" + ] + }, + { + "cell_type": "code", + "execution_count": 15, + "id": "a408094f", + "metadata": {}, + "outputs": [], + "source": [ + "export.export_bnet()\n", + "export.export_sif()" + ] + }, + { + "cell_type": "markdown", + "id": "8ed135d3-9f71-4cec-9381-96c63fba766e", + "metadata": {}, + "source": [ + "### Gene Ontology\n", + "## A new feature of Omniflow. Now, the user can connect the nodes of the Network with markers of a certain phenotype, from Gene Ontology. " + ] + }, + { + "cell_type": "code", + "execution_count": 10, + "id": "fa499a38-c22a-4a0e-b1d4-3ffb10e4a370", + "metadata": {}, + "outputs": [ + { + "name": "stdout", + "output_type": "stream", + "text": [ + "Start requesting genes from Gene Ontology\n", + "Fetching from: https://golr-aux.geneontology.io/solr/select?defType=edismax&qt=standard&indent=on&wt=csv&rows=100000&start=0&fl=bioentity_label&facet=true&facet.mincount=1&facet.sort=count&json.nl=arrarr&facet.limit=25&hl=true&hl.simple.pre=%3Cem%20class=%22hilite%22%3E&hl.snippets=1000&csv.encapsulator=&csv.separator=%09&csv.header=false&csv.mv.separator=%7C&fq=document_category:%22annotation%22&fq=isa_partof_closure:%22GO:0097194%22&fq=taxon_subset_closure_label:%22Homo%20sapiens%22&fq=type:%22protein%22&fq=annotation_class_label:%22execution%20phase%20of%20apoptosis%22&facet.field=aspect&facet.field=taxon_subset_closure_label&facet.field=type&facet.field=evidence_subset_closure_label&facet.field=regulates_closure_label&facet.field=isa_partof_closure_label&facet.field=annotation_class_label&facet.field=qualifier&facet.field=annotation_extension_class_closure_label&facet.field=assigned_by&facet.field=panther_family_label&q=*:*\n", + "Done\n", + "Starting connecting network's nodes to: ['AIFM3', 'CASP7', 'MADD', 'CASP3', 'CASP8', 'CASP5', 'BNIP1', 'CIDEC', 'COLEC11', 'HTRA2', 'CASP12', 'TAOK1', 'BBC3', 'CFLAR', 'CIDEB', 'NFKBIZ', 'CASP6', 'STK24', 'CASP4', 'AKT1', 'NPR2', 'CASP2', 'CECR2']\n", + "Q01094 Q96PG8\n", + "P28482 Q14790\n", + "P31749 O15519\n", + "P31749 O43464\n", + "P06493 Q14790\n", + "P62136 P42575\n", + "SIGNOR-PF54 P42575\n", + "Q13315 Q7L7X3\n", + "P68400 P42575\n", + "Q16539 O15519\n", + "Q16539 P42574\n", + "Q16539 Q14790\n", + "P27361 Q14790\n", + "SIGNOR-PF1 Q14790\n", + "CPU times: user 1.17 s, sys: 1.02 ms, total: 1.17 s\n", + "Wall time: 1.98 s\n" + ] + } + ], + "source": [ + "%%time\n", + "new_net1.connect_genes_to_phenotype(id_accession=\"GO:0097194\", phenotype=\"execution phase of apoptosis\", only_signed=True, compress=True, maxlen=1)" + ] + }, + { + "cell_type": "markdown", + "id": "48bf53a4", + "metadata": {}, + "source": [ + "# TO DO:\n", + "\n", + "- method to print sif file with reference for each interaction (easy task)\n", + "- more utility functions (???)\n", + "- create function to look for common upstream for group of nodes" + ] + }, + { + "cell_type": "code", + "execution_count": null, + "id": "33300268-bcf6-442b-97be-c7718922a939", + "metadata": {}, + "outputs": [], + "source": [] + } + ], + "metadata": { + "kernelspec": { + "display_name": "Python 3 (ipykernel)", + "language": "python", + "name": "python3" + }, + "language_info": { + "codemirror_mode": { + "name": "ipython", + "version": 3 + }, + "file_extension": ".py", + "mimetype": "text/x-python", + "name": "python", + "nbconvert_exporter": "python", + "pygments_lexer": "ipython3", + "version": "3.10.13" + } + }, + "nbformat": 4, + "nbformat_minor": 5 +} diff --git a/notebooks/.ipynb_checkpoints/tissue_mapping-checkpoint.ipynb b/notebooks/.ipynb_checkpoints/tissue_mapping-checkpoint.ipynb new file mode 100644 index 0000000..0b5a01c --- /dev/null +++ b/notebooks/.ipynb_checkpoints/tissue_mapping-checkpoint.ipynb @@ -0,0 +1,986 @@ +{ + "cells": [ + { + "cell_type": "markdown", + "id": "55b5595c-fec9-41c3-b756-b95cd0c52048", + "metadata": {}, + "source": [ + "## Map tissue expression\n", + "\n", + "This notebook explores how you can explore whether the nodes in your network are expressed in a tissue of interest. The annotations are accessed from the Annotation object of Omnipath, and are based on expression data from the Human Protein Atlas." + ] + }, + { + "cell_type": "code", + "execution_count": 2, + "id": "3c317de8", + "metadata": {}, + "outputs": [ + { + "name": "stderr", + "output_type": "stream", + "text": [ + "/home/eirini/anaconda3/envs/omniflow_env/lib/python3.10/site-packages/tqdm/auto.py:21: TqdmWarning: IProgress not found. Please update jupyter and ipywidgets. See https://ipywidgets.readthedocs.io/en/stable/user_install.html\n", + " from .autonotebook import tqdm as notebook_tqdm\n" + ] + }, + { + "ename": "ModuleNotFoundError", + "evalue": "No module named 'omniflow_project._annotations'", + "output_type": "error", + "traceback": [ + "\u001b[0;31m---------------------------------------------------------------------------\u001b[0m", + "\u001b[0;31mModuleNotFoundError\u001b[0m Traceback (most recent call last)", + "File \u001b[0;32m:4\u001b[0m\n", + "\u001b[0;31mModuleNotFoundError\u001b[0m: No module named 'omniflow_project._annotations'" + ] + } + ], + "source": [ + "%%time\n", + "from omniflow_project.core.network import Network\n", + "from omniflow_project._visual.visualize_network import NetworkVisualizer\n", + "from omniflow_project._inputs.resources import Resources\n", + "from omniflow_project._annotations.gene_ontology import Ontology\n", + "import omnipath as op" + ] + }, + { + "cell_type": "markdown", + "id": "2910c871-fdfc-4d20-b76f-af213f06a3f0", + "metadata": {}, + "source": [ + "### 1. Import genes as network nodes" + ] + }, + { + "cell_type": "code", + "execution_count": 3, + "id": "79c09e13", + "metadata": {}, + "outputs": [], + "source": [ + "genes = [\"SRC\", \"NOTCH1\", \"FAK\", \"CDH1\", \"CDH2\", \"VIM\", \"MAP4K4\", \"LATS1\", \"LATS2\", \"PTK2B\"]" + ] + }, + { + "cell_type": "code", + "execution_count": 3, + "id": "fcf68a99-8454-41e3-8816-c3f976d04c0b", + "metadata": {}, + "outputs": [ + { + "name": "stdout", + "output_type": "stream", + "text": [ + "Loading deafault omnipath all interactions\n" + ] + } + ], + "source": [ + "new_net1 = Network(genes)" + ] + }, + { + "cell_type": "code", + "execution_count": 4, + "id": "fad00bec-ba72-4943-bf1e-9c60f58f17a2", + "metadata": {}, + "outputs": [ + { + "ename": "NameError", + "evalue": "name 'new_net1' is not defined", + "output_type": "error", + "traceback": [ + "\u001b[0;31m---------------------------------------------------------------------------\u001b[0m", + "\u001b[0;31mNameError\u001b[0m Traceback (most recent call last)", + "Cell \u001b[0;32mIn[4], line 2\u001b[0m\n\u001b[1;32m 1\u001b[0m \u001b[38;5;66;03m#Print node dataframe\u001b[39;00m\n\u001b[0;32m----> 2\u001b[0m \u001b[43mnew_net1\u001b[49m\u001b[38;5;241m.\u001b[39mnodes\n", + "\u001b[0;31mNameError\u001b[0m: name 'new_net1' is not defined" + ] + } + ], + "source": [ + "#Print node dataframe\n", + "new_net1.nodes" + ] + }, + { + "cell_type": "markdown", + "id": "3e9006ec-00d2-453d-8b8f-e939938e9068", + "metadata": {}, + "source": [ + "### 2. Check if the genes are annotated in the tissue of interest (e.g., in colorectal cancer)" + ] + }, + { + "cell_type": "code", + "execution_count": 13, + "id": "9540f33d-68f8-4c98-b68e-3e3d1497467e", + "metadata": {}, + "outputs": [ + { + "name": "stdout", + "output_type": "stream", + "text": [ + " Genesymbol in_tissue\n", + "0 SRC True\n", + "1 NOTCH1 True\n", + "2 PTK2 True\n", + "3 CDH1 True\n", + "4 CDH2 True\n", + "5 VIM True\n", + "6 MAP4K4 True\n", + "7 LATS1 True\n", + "8 LATS2 True\n", + "9 PTK2B True\n", + "10 CTNNB1 True\n", + "11 DAB1 True\n", + "12 MET True\n", + "13 PRKD1 True\n", + "14 CTNND1 True\n", + "15 PAK2 True\n", + "16 MAPK8 True\n", + "17 MAP3K7 True\n", + "18 MAP3K1 True\n", + "19 RAF1 True\n", + "20 STK3 True\n", + "21 STK4 True\n", + "22 NF2 True\n", + "23 SMAD3 True\n", + "24 BCAR1 True\n", + "25 LCK True\n", + "26 PTPRH True\n", + "27 WWTR1 True\n", + "28 YAP1 True\n", + "29 RUNX2 True\n", + "30 EGFR True\n" + ] + } + ], + "source": [ + "annot = Ontology()\n", + "results_df = annot.check_tissue_annotations(genes_df = new_net1.nodes, tissue = 'colorectal cancer')\n", + "print(results_df)" + ] + }, + { + "cell_type": "markdown", + "id": "6a05e120-424b-405f-be04-f8c3725f950b", + "metadata": {}, + "source": [ + "### 3. Color nodes based on their presence/absence in the tissue of interest" + ] + }, + { + "cell_type": "code", + "execution_count": 12, + "id": "fbd98405-045a-4316-8174-e96e9a71d9ee", + "metadata": {}, + "outputs": [ + { + "data": { + "image/svg+xml": [ + "\n", + "\n", + "\n", + "\n", + "\n", + "\n", + "%3\n", + "\n", + "\n", + "\n", + "SRC\n", + "\n", + "SRC\n", + "\n", + "\n", + "\n", + "PTK2\n", + "\n", + "PTK2\n", + "\n", + "\n", + "\n", + "SRC->PTK2\n", + "\n", + "\n", + "\n", + "\n", + "\n", + "CDH2\n", + "\n", + "CDH2\n", + "\n", + "\n", + "\n", + "SRC->CDH2\n", + "\n", + "\n", + "\n", + "\n", + "\n", + "\n", + "PTK2B\n", + "\n", + "PTK2B\n", + "\n", + "\n", + "\n", + "SRC->PTK2B\n", + "\n", + "\n", + "\n", + "\n", + "\n", + "CTNNB1\n", + "\n", + "CTNNB1\n", + "\n", + "\n", + "\n", + "SRC->CTNNB1\n", + "\n", + "\n", + "\n", + "\n", + "\n", + "DAB1\n", + "\n", + "DAB1\n", + "\n", + "\n", + "\n", + "SRC->DAB1\n", + "\n", + "\n", + "\n", + "\n", + "\n", + "MET\n", + "\n", + "MET\n", + 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+ "metadata": { + "kernelspec": { + "display_name": "Python 3 (ipykernel)", + "language": "python", + "name": "python3" + }, + "language_info": { + "codemirror_mode": { + "name": "ipython", + "version": 3 + }, + "file_extension": ".py", + "mimetype": "text/x-python", + "name": "python", + "nbconvert_exporter": "python", + "pygments_lexer": "ipython3", + "version": "3.10.13" + } + }, + "nbformat": 4, + "nbformat_minor": 5 +} diff --git a/notebooks/add_resources.ipynb b/notebooks/add_resources.ipynb new file mode 100644 index 0000000..95fc5e4 --- /dev/null +++ b/notebooks/add_resources.ipynb @@ -0,0 +1,2948 @@ +{ + "cells": [ + { + "cell_type": "markdown", + "id": "55b5595c-fec9-41c3-b756-b95cd0c52048", + "metadata": {}, + "source": [ + "## Add resources\n", + "\n", + "This notebook explores how to add other individual resources from Omnipath or other public databased." + ] + }, + { + "cell_type": "code", + "execution_count": 1, + "id": "3c317de8", + "metadata": {}, + "outputs": [ + { + "name": "stderr", + "output_type": "stream", + "text": [ + "/home/eirini/anaconda3/envs/omniflow_env/lib/python3.10/site-packages/tqdm/auto.py:21: TqdmWarning: IProgress not found. Please update jupyter and ipywidgets. See https://ipywidgets.readthedocs.io/en/stable/user_install.html\n", + " from .autonotebook import tqdm as notebook_tqdm\n" + ] + }, + { + "name": "stdout", + "output_type": "stream", + "text": [ + "CPU times: user 1.75 s, sys: 374 ms, total: 2.12 s\n", + "Wall time: 2.36 s\n" + ] + } + ], + "source": [ + "%%time\n", + "from omniflow_project.core.network import Network\n", + "from omniflow_project._visual.visualize_network import NetworkVisualizer\n", + "from omniflow_project._inputs.resources import Resources\n", + "from omniflow_project._annotations.gene_ontology import Ontology\n", + "import omnipath as op" + ] + }, + { + "cell_type": "markdown", + "id": "2a250d98", + "metadata": {}, + "source": [ + "## Adding a resource already in Omnipath\n", + "\n" + ] + }, + { + "cell_type": "markdown", + "id": "e5a3b471-0e53-47b6-a986-95e278b94ece", + "metadata": {}, + "source": [ + "#### 1. Get all interactions from OmniPath" + ] + }, + { + "cell_type": "code", + "execution_count": 2, + "id": "794f4de1", + "metadata": {}, + "outputs": [], + "source": [ + "interactions = op.interactions.AllInteractions.get() " + ] + }, + { + "cell_type": "markdown", + "id": "aeec437c", + "metadata": {}, + "source": [ + "#### 2. Add all interactions in the Resources object" + ] + }, + { + "cell_type": "code", + "execution_count": 3, + "id": "d45b7920", + "metadata": {}, + "outputs": [ + { + "name": "stderr", + "output_type": "stream", + "text": [ + "WARNING:root:The incoming database is missing some required columns: {'form_complex'}\n", + "WARNING:root:This might lead to issues in running the package.\n" + ] + } + ], + "source": [ + "resources = Resources()\n", + "resources.add_database(interactions)" + ] + }, + { + "cell_type": "code", + "execution_count": 4, + "id": "8dfed589", + "metadata": {}, + "outputs": [ + { + "data": { + "text/html": [ + "
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sourcetargetis_directedis_stimulationis_inhibitionconsensus_directionconsensus_stimulationconsensus_inhibitioncuration_effortreferencessourcestypen_sourcesn_primary_sourcesn_referencesreferences_stripped
0P0DP23P48995TrueFalseTrueTrueFalseTrue3TRIP:11290752;TRIP:11983166;TRIP:12601176TRIPpost_translational11311290752;11983166;12601176
1P0DP25P48995TrueFalseTrueTrueFalseTrue3TRIP:11290752;TRIP:11983166;TRIP:12601176TRIPpost_translational11311290752;11983166;12601176
2P0DP24P48995TrueFalseTrueTrueFalseTrue3TRIP:11290752;TRIP:11983166;TRIP:12601176TRIPpost_translational11311290752;11983166;12601176
3Q03135P48995TrueTrueFalseTrueTrueFalse13DIP:19897728;HPRD:12732636;IntAct:19897728;Lit...DIP;HPRD;IntAct;Lit-BM-17;TRIPpost_translational55810980191;12732636;14551243;16822931;18430726;1...
4P14416P48995TrueTrueFalseTrueTrueFalse1TRIP:18261457TRIPpost_translational11118261457
...................................................
2824995280360P34995TrueFalseFalseFalseFalseFalse3Cellinker:10634944;Cellinker:11999132;Cellinke...Cellinker;Guide2Pharma_Cellinkersmall_molecule_protein21310634944;11999132;16604093
282500448457P34995TrueFalseFalseFalseFalseFalse1Cellinker:11999132Cellinker;Guide2Pharma_Cellinkersmall_molecule_protein21111999132
2825015311358P48544TrueFalseFalseFalseFalseFalse2Cellinker:8688080;Cellinker:9804555Cellinker;Guide2Pharma_Cellinkersmall_molecule_protein2128688080;9804555
282502439260P35348TrueFalseFalseFalseFalseFalse3Cellinker:10433504;Cellinker:7651358;Cellinker...Cellinker;Guide2Pharma_Cellinkersmall_molecule_protein21310433504;7651358;8564227
28250333032O00222TrueFalseFalseFalseFalseFalse1Cellinker:10443583Cellinker;Guide2Pharma_Cellinkersmall_molecule_protein21110443583
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282504 rows × 16 columns

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" + ], + "text/plain": [ + " source target is_directed is_stimulation is_inhibition \\\n", + "0 P0DP23 P48995 True False True \n", + "1 P0DP25 P48995 True False True \n", + "2 P0DP24 P48995 True False True \n", + "3 Q03135 P48995 True True False \n", + "4 P14416 P48995 True True False \n", + "... ... ... ... ... ... \n", + "282499 5280360 P34995 True False False \n", + "282500 448457 P34995 True False False \n", + "282501 5311358 P48544 True False False \n", + "282502 439260 P35348 True False False \n", + "282503 33032 O00222 True False False \n", + "\n", + " consensus_direction consensus_stimulation consensus_inhibition \\\n", + "0 True False True \n", + "1 True False True \n", + "2 True False True \n", + "3 True True False \n", + "4 True True False \n", + "... ... ... ... \n", + "282499 False False False \n", + "282500 False False False \n", + "282501 False False False \n", + "282502 False False False \n", + "282503 False False False \n", + "\n", + " curation_effort references \\\n", + "0 3 TRIP:11290752;TRIP:11983166;TRIP:12601176 \n", + "1 3 TRIP:11290752;TRIP:11983166;TRIP:12601176 \n", + "2 3 TRIP:11290752;TRIP:11983166;TRIP:12601176 \n", + "3 13 DIP:19897728;HPRD:12732636;IntAct:19897728;Lit... \n", + "4 1 TRIP:18261457 \n", + "... ... ... \n", + "282499 3 Cellinker:10634944;Cellinker:11999132;Cellinke... \n", + "282500 1 Cellinker:11999132 \n", + "282501 2 Cellinker:8688080;Cellinker:9804555 \n", + "282502 3 Cellinker:10433504;Cellinker:7651358;Cellinker... \n", + "282503 1 Cellinker:10443583 \n", + "\n", + " sources type n_sources \\\n", + "0 TRIP post_translational 1 \n", + "1 TRIP post_translational 1 \n", + "2 TRIP post_translational 1 \n", + "3 DIP;HPRD;IntAct;Lit-BM-17;TRIP post_translational 5 \n", + "4 TRIP post_translational 1 \n", + "... ... ... ... \n", + "282499 Cellinker;Guide2Pharma_Cellinker small_molecule_protein 2 \n", + "282500 Cellinker;Guide2Pharma_Cellinker small_molecule_protein 2 \n", + "282501 Cellinker;Guide2Pharma_Cellinker small_molecule_protein 2 \n", + "282502 Cellinker;Guide2Pharma_Cellinker small_molecule_protein 2 \n", + "282503 Cellinker;Guide2Pharma_Cellinker small_molecule_protein 2 \n", + "\n", + " n_primary_sources n_references \\\n", + "0 1 3 \n", + "1 1 3 \n", + "2 1 3 \n", + "3 5 8 \n", + "4 1 1 \n", + "... ... ... \n", + "282499 1 3 \n", + "282500 1 1 \n", + "282501 1 2 \n", + "282502 1 3 \n", + "282503 1 1 \n", + "\n", + " references_stripped \n", + "0 11290752;11983166;12601176 \n", + "1 11290752;11983166;12601176 \n", + "2 11290752;11983166;12601176 \n", + "3 10980191;12732636;14551243;16822931;18430726;1... \n", + "4 18261457 \n", + "... ... \n", + "282499 10634944;11999132;16604093 \n", + "282500 11999132 \n", + "282501 8688080;9804555 \n", + "282502 10433504;7651358;8564227 \n", + "282503 10443583 \n", + "\n", + "[282504 rows x 16 columns]" + ] + }, + "execution_count": 4, + "metadata": {}, + "output_type": "execute_result" + } + ], + "source": [ + "resources.interactions" + ] + }, + { + "cell_type": "markdown", + "id": "d3dca809", + "metadata": {}, + "source": [ + "#### 3. Add interactions from a specific resource. " + ] + }, + { + "cell_type": "markdown", + "id": "0e6b2c56-80cd-459b-984a-fa235c1a0085", + "metadata": {}, + "source": [ + "#### 3A. Specify the interaction resource of interest" + ] + }, + { + "cell_type": "code", + "execution_count": 5, + "id": "829de33a", + "metadata": {}, + "outputs": [ + { + "name": "stderr", + "output_type": "stream", + "text": [ + "1.20MB [00:00, 19.7MB/s]\n" + ] + } + ], + "source": [ + "extra = op.interactions.LigRecExtra.get()" + ] + }, + { + "cell_type": "markdown", + "id": "fc585a3c", + "metadata": {}, + "source": [ + "#### 3B. Add new resource to the Resources object" + ] + }, + { + "cell_type": "code", + "execution_count": 6, + "id": "91ae2cef", + "metadata": {}, + "outputs": [ + { + "name": "stderr", + "output_type": "stream", + "text": [ + "WARNING:root:The incoming database is missing some required columns: {'form_complex'}\n", + "WARNING:root:This might lead to issues in running the package.\n" + ] + } + ], + "source": [ + "resources.add_database(extra, reset_index=True)" + ] + }, + { + "cell_type": "markdown", + "id": "8fe2700c-5b59-4302-9a9e-cc2de59d34af", + "metadata": {}, + "source": [ + "### 4. Build the network" + ] + }, + { + "cell_type": "markdown", + "id": "2910c871-fdfc-4d20-b76f-af213f06a3f0", + "metadata": {}, + "source": [ + "#### 4A. Import genes as network nodes" + ] + }, + { + "cell_type": "code", + "execution_count": 7, + "id": "79c09e13", + "metadata": {}, + "outputs": [], + "source": [ + "genes = [\"SRC\", \"NOTCH1\", \"FAK\", \"CDH1\", \"CDH2\", \"VIM\", \"MAP4K4\", \"LATS1\", \"LATS2\", \"PTK2B\"]" + ] + }, + { + "cell_type": "code", + "execution_count": 8, + "id": "fcf68a99-8454-41e3-8816-c3f976d04c0b", + "metadata": {}, + "outputs": [ + { + "name": "stdout", + "output_type": "stream", + "text": [ + "Loading deafault omnipath all interactions\n" + ] + } + ], + "source": [ + "new_net1 = Network(genes)" + ] + }, + { + "cell_type": "code", + "execution_count": 9, + "id": "fad00bec-ba72-4943-bf1e-9c60f58f17a2", + "metadata": {}, + "outputs": [ + { + "data": { + "text/html": [ + "
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" + ], + "text/plain": [ + " Genesymbol Uniprot Type\n", + "0 SRC P12931 NaN\n", + "1 NOTCH1 P46531 NaN\n", + "2 PTK2 Q05397 NaN\n", + "3 CDH1 P12830 NaN\n", + "4 CDH2 P19022 NaN\n", + "5 VIM P08670 NaN\n", + "6 MAP4K4 O95819 NaN\n", + "7 LATS1 O95835 NaN\n", + "8 LATS2 Q9NRM7 NaN\n", + "9 PTK2B Q14289 NaN" + ] + }, + "execution_count": 9, + "metadata": {}, + "output_type": "execute_result" + } + ], + "source": [ + "#Print node dataframe\n", + "new_net1.nodes" + ] + }, + { + "cell_type": "markdown", + "id": "a2759581", + "metadata": {}, + "source": [ + "#### 4B. Explore if the nodes are connected without introducing new intermidiate nodes" + ] + }, + { + "cell_type": "code", + "execution_count": 10, + "id": "a339705b", + "metadata": {}, + "outputs": [ + { + "name": "stdout", + "output_type": "stream", + "text": [ + "P12931 Q05397\n", + "P12931 P19022\n", + "P12931 Q14289\n", + "Q14289 Q05397\n", + "CPU times: user 956 ms, sys: 3.96 ms, total: 960 ms\n", + "Wall time: 959 ms\n" + ] + } + ], + "source": [ + "%%time\n", + "new_net1.connect_nodes(only_signed=True, consensus_only=True)" + ] + }, + { + "cell_type": "markdown", + "id": "2fb5674d", + "metadata": {}, + "source": [ + "#### 4C. Visualize the network with the following command. \n", + "\n", + "The network picture is also exported in the working repository, in pdf format." + ] + }, + { + "cell_type": "code", + "execution_count": 11, + "id": "db39112a", + "metadata": {}, + "outputs": [ + { + "data": { + "image/svg+xml": [ + "\n", + "\n", + "\n", + "\n", + "\n", + "\n", + "%3\n", + "\n", + "\n", + "\n", + "SRC\n", + "\n", + "SRC\n", + "\n", + "\n", + "\n", + "PTK2\n", + "\n", + "PTK2\n", + "\n", + "\n", + "\n", + "SRC->PTK2\n", + "\n", + "\n", + "\n", + "\n", + "\n", + "CDH2\n", + "\n", + "CDH2\n", + "\n", + "\n", + "\n", + "SRC->CDH2\n", + "\n", + "\n", + "\n", + "\n", + "\n", + "\n", + "PTK2B\n", + "\n", + "PTK2B\n", + "\n", + "\n", + "\n", + "SRC->PTK2B\n", + "\n", + "\n", + "\n", + "\n", + "\n", + "PTK2B->PTK2\n", + "\n", + "\n", + "\n", + "\n", + "\n", + "NOTCH1\n", + "\n", + "NOTCH1\n", + "\n", + "\n", + "\n", + "CDH1\n", + "\n", + "CDH1\n", + "\n", + "\n", + "\n", + "VIM\n", + "\n", + "VIM\n", + "\n", + "\n", + "\n", + "MAP4K4\n", + "\n", + "MAP4K4\n", + "\n", + "\n", + "\n", + "LATS1\n", + "\n", + "LATS1\n", + "\n", + "\n", + "\n", + "LATS2\n", + "\n", + "LATS2\n", + "\n", + "\n", + "\n" + ], + "text/plain": [ + "" + ] + }, + "metadata": {}, + "output_type": "display_data" + } + ], + "source": [ + "visualizer = NetworkVisualizer(new_net1, color_by='effect')\n", + "visualizer.render(output_file=\"new_network\")" + ] + }, + { + "cell_type": "markdown", + "id": "3c1725cc-4c08-4a85-b26c-8f59936e351d", + "metadata": {}, + "source": [ + "#### 4D. Connect disconnected nodes by importing intermediate nodes.\n", + "\n", + "The parameter _*maxlen*_ is used to verify that in the network all the nodes have a distance < than maxlen. \n", + "\n", + "The parameter _*only_signed*_ forces the algorithm to look for just signed interactions. \n", + "\n", + "The parameter _*consensus*_ retrieves those interactions with a sign consensus between the references. \n", + "\n", + "The parameter _*connect_node_when_first_introduced*_, changes the base algorithm, making it look for possible connection between all the disconnected node in the network when a new bridge-gene is introduced in the network." + ] + }, + { + "cell_type": "code", + "execution_count": 12, + "id": "9a07d77b", + "metadata": {}, + "outputs": [ + { + "name": "stdout", + "output_type": "stream", + "text": [ + "looking for paths in the network with length: 0 for node SRC and NOTCH1\n", + "looking for paths in the network with length: 1 for node SRC and NOTCH1\n", + "looking for paths in the network with length: 2 for node SRC and NOTCH1\n", + "looking for paths in the network with length: 3 for node SRC and NOTCH1\n", + "looking for paths in the network with length: 4 for node SRC and NOTCH1\n", + "looking for paths in the network with length: 5 for node SRC and NOTCH1\n", + "looking for paths in the network with length: 6 for node SRC and NOTCH1\n", + "i_search = 3\n", + "Looking for paths with length: 0 for node SRC and NOTCH1\n", + "i_search = 3\n", + "Looking for paths with length: 1 for node SRC and NOTCH1\n", + "i_search = 3\n", + "Looking for paths with length: 2 for node SRC and NOTCH1\n", + "[['SRC', 'DAB1', 'NOTCH1'], ['SRC', 'CTNNB1', 'NOTCH1']]\n", + "P12931 O75553\n", + "O75553 P46531\n", + "P12931 P35222\n", + "P35222 P46531\n", + "P12931 Q05397\n", + "P12931 P19022\n", + "P12931 Q14289\n", + "P12931 O75553\n", + "P12931 P35222\n", + "O75553 P46531\n", + "P35222 P46531\n", + "Q14289 Q05397\n", + "P12830 P35222\n", + "P19022 P35222\n", + "looking for paths in the network with length: 0 for node SRC and PTK2\n", + "looking for paths in the network with length: 1 for node SRC and PTK2\n", + "Found a path!\n", + "[['SRC', 'PTK2']]\n", + "looking for paths in the network with length: 0 for node SRC and CDH1\n", + "looking for paths in the network with length: 1 for node SRC and CDH1\n", + "looking for paths in the network with length: 2 for node SRC and CDH1\n", + "looking for paths in the network with length: 3 for node SRC and CDH1\n", + "looking for paths in the network with length: 4 for node SRC and CDH1\n", + "looking for paths in the network with length: 5 for node SRC and CDH1\n", + "looking for paths in the network with length: 6 for node SRC and CDH1\n", + "i_search = 3\n", + "Looking for paths with length: 0 for node SRC and CDH1\n", + "i_search = 3\n", + "Looking for paths with length: 1 for node SRC and CDH1\n", + "i_search = 3\n", + "Looking for paths with length: 2 for node SRC and CDH1\n", + "[['SRC', 'MET', 'CDH1'], ['SRC', 'CTNND1', 'CDH1'], ['SRC', 'PRKD1', 'CDH1']]\n", + "P12931 P08581\n", + "P08581 P12830\n", + "P12931 O60716\n", + "O60716 P12830\n", + "P12931 Q15139\n", + "Q15139 P12830\n", + "P12931 Q05397\n", + "P12931 P19022\n", + "P12931 Q14289\n", + "P12931 O75553\n", + "P12931 P35222\n", + "P12931 P08581\n", + "P12931 O60716\n", + "P12931 Q15139\n", + "O75553 P46531\n", + "P35222 P46531\n", + "Q14289 Q05397\n", + "P08581 Q05397\n", + "P12830 P35222\n", + "P08581 P12830\n", + "O60716 P12830\n", + "Q15139 P12830\n", + "P19022 P35222\n", + "O60716 P19022\n", + "Q15139 P35222\n", + "looking for paths in the network with length: 0 for node SRC and CDH2\n", + "looking for paths in the network with length: 1 for node SRC and CDH2\n", + "Found a path!\n", + "[['SRC', 'CDH2']]\n", + "looking for paths in the network with length: 0 for node SRC and VIM\n", + "looking for paths in the network with length: 1 for node SRC and VIM\n", + "looking for paths in the network with length: 2 for node SRC and VIM\n", + "looking for paths in the network with length: 3 for node SRC and VIM\n", + "looking for paths in the network with length: 4 for node SRC and VIM\n", + "looking for paths in the network with length: 5 for node SRC and VIM\n", + "looking for paths in the network with length: 6 for node SRC and VIM\n", + "i_search = 3\n", + "Looking for paths with length: 0 for node SRC and VIM\n", + "i_search = 3\n", + "Looking for paths with length: 1 for node SRC and VIM\n", + "i_search = 3\n", + "Looking for paths with length: 2 for node SRC and VIM\n", + "[['SRC', 'PAK2', 'VIM']]\n", + "P12931 Q13177\n", + "Q13177 P08670\n", + "P12931 Q05397\n", + "P12931 P19022\n", + "P12931 Q14289\n", + "P12931 O75553\n", + "P12931 P35222\n", + "P12931 P08581\n", + "P12931 O60716\n", + "P12931 Q15139\n", + "P12931 Q13177\n", + "O75553 P46531\n", + "P35222 P46531\n", + "Q14289 Q05397\n", + "P08581 Q05397\n", + "P12830 P35222\n", + "P08581 P12830\n", + "O60716 P12830\n", + "Q15139 P12830\n", + "P19022 P35222\n", + "O60716 P19022\n", + "Q13177 P08670\n", + "Q15139 P35222\n", + "looking for paths in the network with length: 0 for node SRC and MAP4K4\n", + "looking for paths in the network with length: 1 for node SRC and MAP4K4\n", + "looking for paths in the network with length: 2 for node SRC and MAP4K4\n", + "looking for paths in the network with length: 3 for node SRC and MAP4K4\n", + "looking for paths in the network with length: 4 for node SRC and MAP4K4\n", + "looking for paths in the network with length: 5 for node SRC and MAP4K4\n", + "looking for paths in the network with length: 6 for node SRC and MAP4K4\n", + "i_search = 3\n", + "Looking for paths with length: 0 for node SRC and MAP4K4\n", + "i_search = 3\n", + "Looking for paths with length: 1 for node SRC and MAP4K4\n", + "i_search = 3\n", + "Looking for paths with length: 2 for node SRC and MAP4K4\n", + "i_search = 3\n", + "Looking for paths with length: 3 for node SRC and MAP4K4\n", + "[['SRC', 'MAPK8', 'MAP3K7', 'MAP4K4'], ['SRC', 'MAPK8', 'MAP3K1', 'MAP4K4']]\n", + "P45983 P12931\n", + "O43318 P45983\n", + "O95819 O43318\n", + "P45983 P12931\n", + "Q13233 P45983\n", + "O95819 Q13233\n", + "P12931 Q05397\n", + "P12931 P19022\n", + "P12931 Q14289\n", + "P12931 O75553\n", + "P12931 P35222\n", + "P12931 P08581\n", + "P12931 O60716\n", + "P12931 Q15139\n", + "P12931 Q13177\n", + "P45983 P12931\n", + "O75553 P46531\n", + "P35222 P46531\n", + "Q14289 Q05397\n", + "P08581 Q05397\n", + "P12830 P35222\n", + "P08581 P12830\n", + "O60716 P12830\n", + "Q15139 P12830\n", + "P19022 P35222\n", + "O60716 P19022\n", + "Q13177 P08670\n", + "O95819 O43318\n", + "O95819 Q13233\n", + "Q15139 P35222\n", + "O43318 P45983\n", + "Q13233 P45983\n", + "looking for paths in the network with length: 0 for node SRC and LATS1\n", + "looking for paths in the network with length: 1 for node SRC and LATS1\n", + "looking for paths in the network with length: 2 for node SRC and LATS1\n", + "looking for paths in the network with length: 3 for node SRC and LATS1\n", + "looking for paths in the network with length: 4 for node SRC and LATS1\n", + "looking for paths in the network with length: 5 for node SRC and LATS1\n", + "looking for paths in the network with length: 6 for node SRC and LATS1\n", + "i_search = 3\n", + "Looking for paths with length: 0 for node SRC and LATS1\n", + "i_search = 3\n", + "Looking for paths with length: 1 for node SRC and LATS1\n", + "i_search = 3\n", + "Looking for paths with length: 2 for node SRC and LATS1\n", + "i_search = 3\n", + "Looking for paths with length: 3 for node SRC and LATS1\n", + "[['SRC', 'RAF1', 'STK3', 'LATS1'], ['SRC', 'RAF1', 'STK4', 'LATS1'], ['SRC', 'PAK2', 'NF2', 'LATS1']]\n", + "P12931 P04049\n", + "P04049 Q13188\n", + "Q13188 O95835\n", + "P12931 P04049\n", + "P04049 Q13043\n", + "Q13043 O95835\n", + "P12931 Q13177\n", + "Q13177 P35240\n", + "P35240 O95835\n", + "P12931 Q05397\n", + "P12931 P19022\n", + "P12931 Q14289\n", + "P12931 O75553\n", + "P12931 P35222\n", + "P12931 P08581\n", + "P12931 O60716\n", + "P12931 Q15139\n", + "P12931 Q13177\n", + "P45983 P12931\n", + "P12931 P04049\n", + "O75553 P46531\n", + "P35222 P46531\n", + "Q14289 Q05397\n", + "P08581 Q05397\n", + "P12830 P35222\n", + "P08581 P12830\n", + "O60716 P12830\n", + "Q15139 P12830\n", + "P19022 P35222\n", + "O60716 P19022\n", + "Q13177 P08670\n", + "O95819 O43318\n", + "O95819 Q13233\n", + "Q13188 O95835\n", + "Q13043 O95835\n", + "P35240 O95835\n", + "Q13188 Q9NRM7\n", + "Q13043 Q9NRM7\n", + "P35240 Q9NRM7\n", + "Q15139 P35222\n", + "Q13177 P04049\n", + "Q13177 P35240\n", + "O43318 P45983\n", + "Q13233 P45983\n", + "P45983 Q13043\n", + "P04049 Q13188\n", + "P04049 Q13043\n", + "P35240 Q13188\n", + "P35240 Q13043\n", + "looking for paths in the network with length: 0 for node SRC and LATS2\n", + "looking for paths in the network with length: 1 for node SRC and LATS2\n", + "looking for paths in the network with length: 2 for node SRC and LATS2\n", + "looking for paths in the network with length: 3 for node SRC and LATS2\n", + "Found a path!\n", + "[['SRC', 'RAF1', 'STK3', 'LATS2'], ['SRC', 'RAF1', 'STK4', 'LATS2'], ['SRC', 'PAK2', 'NF2', 'LATS2']]\n", + "looking for paths in the network with length: 0 for node SRC and PTK2B\n", + "looking for paths in the network with length: 1 for node SRC and PTK2B\n", + "Found a path!\n", + "[['SRC', 'PTK2B']]\n", + "looking for paths in the network with length: 0 for node NOTCH1 and PTK2\n", + "looking for paths in the network with length: 1 for node NOTCH1 and PTK2\n", + "looking for paths in the network with length: 2 for node NOTCH1 and PTK2\n", + "looking for paths in the network with length: 3 for node NOTCH1 and PTK2\n", + "looking for paths in the network with length: 4 for node NOTCH1 and PTK2\n", + "looking for paths in the network with length: 5 for node NOTCH1 and PTK2\n", + "looking for paths in the network with length: 6 for node NOTCH1 and PTK2\n", + "i_search = 3\n", + "Looking for paths with length: 0 for node NOTCH1 and PTK2\n", + "i_search = 3\n", + "Looking for paths with length: 1 for node NOTCH1 and PTK2\n", + "i_search = 3\n", + "Looking for paths with length: 2 for node NOTCH1 and PTK2\n", + "i_search = 3\n", + "Looking for paths with length: 3 for node NOTCH1 and PTK2\n", + "[['NOTCH1', 'SMAD3', 'BCAR1', 'PTK2'], ['NOTCH1', 'LCK', 'PTPRH', 'PTK2']]\n", + "P84022 P46531\n", + "P56945 P84022\n", + "Q05397 P56945\n", + "P06239 P46531\n", + "Q9HD43 P06239\n", + "Q9HD43 Q05397\n", + "P12931 Q05397\n", + "P12931 P19022\n", + "P12931 Q14289\n", + "P12931 O75553\n", + "P12931 P35222\n", + "P12931 P08581\n", + "P12931 O60716\n", + "P12931 Q15139\n", + "P12931 Q13177\n", + "P45983 P12931\n", + "P12931 P04049\n", + "P12931 P56945\n", + "Q9HD43 P12931\n", + "O75553 P46531\n", + "P35222 P46531\n", + "P84022 P46531\n", + "P06239 P46531\n", + "Q14289 Q05397\n", + "P08581 Q05397\n", + "Q05397 P56945\n", + "Q05397 Q9HD43\n", + "Q9HD43 Q05397\n", + "P12830 P35222\n", + "P08581 P12830\n", + "O60716 P12830\n", + "Q15139 P12830\n", + "P19022 P35222\n", + "O60716 P19022\n", + "Q13177 P08670\n", + "O95819 O43318\n", + "O95819 Q13233\n", + "Q13188 O95835\n", + "Q13043 O95835\n", + "P35240 O95835\n", + "Q13188 Q9NRM7\n", + "Q13043 Q9NRM7\n", + "P35240 Q9NRM7\n", + "Q15139 P35222\n", + "Q13177 P04049\n", + "Q13177 P35240\n", + "O43318 P45983\n", + "Q13233 P45983\n", + "P45983 Q13043\n", + "P45983 P84022\n", + "O43318 P84022\n", + "P04049 Q13188\n", + "P04049 Q13043\n", + "P06239 P04049\n", + "P35240 Q13188\n", + "P35240 Q13043\n", + "P56945 P84022\n", + "Q9HD43 P56945\n", + "Q9HD43 P06239\n", + "looking for paths in the network with length: 0 for node NOTCH1 and CDH1\n", + "looking for paths in the network with length: 1 for node NOTCH1 and CDH1\n", + "looking for paths in the network with length: 2 for node NOTCH1 and CDH1\n", + "Found a path!\n", + "[['NOTCH1', 'CTNNB1', 'CDH1']]\n", + "looking for paths in the network with length: 0 for node NOTCH1 and CDH2\n", + "looking for paths in the network with length: 1 for node NOTCH1 and CDH2\n", + "looking for paths in the network with length: 2 for node NOTCH1 and CDH2\n", + "Found a path!\n", + "[['NOTCH1', 'CTNNB1', 'CDH2']]\n", + "looking for paths in the network with length: 0 for node NOTCH1 and VIM\n", + "looking for paths in the network with length: 1 for node NOTCH1 and VIM\n", + "looking for paths in the network with length: 2 for node NOTCH1 and VIM\n", + "looking for paths in the network with length: 3 for node NOTCH1 and VIM\n", + "looking for paths in the network with length: 4 for node NOTCH1 and VIM\n", + "looking for paths in the network with length: 5 for node NOTCH1 and VIM\n", + "looking for paths in the network with length: 6 for node NOTCH1 and VIM\n", + "i_search = 3\n", + "Looking for paths with length: 0 for node NOTCH1 and VIM\n", + "i_search = 3\n", + "Looking for paths with length: 1 for node NOTCH1 and VIM\n", + "i_search = 3\n", + "Looking for paths with length: 2 for node NOTCH1 and VIM\n", + "i_search = 3\n", + "Looking for paths with length: 3 for node NOTCH1 and VIM\n", + "looking for paths in the network with length: 0 for node NOTCH1 and MAP4K4\n", + "looking for paths in the network with length: 1 for node NOTCH1 and MAP4K4\n", + "looking for paths in the network with length: 2 for node NOTCH1 and MAP4K4\n", + "looking for paths in the network with length: 3 for node NOTCH1 and MAP4K4\n", + "Found a path!\n", + "[['NOTCH1', 'SMAD3', 'MAP3K7', 'MAP4K4']]\n", + "looking for paths in the network with length: 0 for node NOTCH1 and LATS1\n", + "looking for paths in the network with length: 1 for node NOTCH1 and LATS1\n", + "looking for paths in the network with length: 2 for node NOTCH1 and LATS1\n", + "looking for paths in the network with length: 3 for node NOTCH1 and LATS1\n", + "looking for paths in the network with length: 4 for node NOTCH1 and LATS1\n", + "looking for paths in the network with length: 5 for node NOTCH1 and LATS1\n", + "looking for paths in the network with length: 6 for node NOTCH1 and LATS1\n", + "i_search = 3\n", + "Looking for paths with length: 0 for node NOTCH1 and LATS1\n", + "i_search = 3\n", + "Looking for paths with length: 1 for node NOTCH1 and LATS1\n", + "i_search = 3\n", + "Looking for paths with length: 2 for node NOTCH1 and LATS1\n", + "i_search = 3\n", + "Looking for paths with length: 3 for node NOTCH1 and LATS1\n", + "[['NOTCH1', 'SMAD3', 'WWTR1', 'LATS1'], ['NOTCH1', 'RUNX2', 'YAP1', 'LATS1'], ['NOTCH1', 'RUNX2', 'WWTR1', 'LATS1'], ['NOTCH1', 'CTNNB1', 'YAP1', 'LATS1']]\n", + "P84022 P46531\n", + "Q9GZV5 P84022\n", + "O95835 Q9GZV5\n", + "Q13950 P46531\n", + "P46937 Q13950\n", + "O95835 P46937\n", + "Q13950 P46531\n", + "Q9GZV5 Q13950\n", + "O95835 Q9GZV5\n", + "P35222 P46531\n", + "P46937 P35222\n", + "O95835 P46937\n", + "P12931 Q05397\n", + "P12931 P19022\n", + "P12931 Q14289\n", + "P12931 O75553\n", + "P12931 P35222\n", + "P12931 P08581\n", + "P12931 O60716\n", + "P12931 Q15139\n", + "P12931 Q13177\n", + "P45983 P12931\n", + "P12931 P04049\n", + "P12931 P56945\n", + "Q9HD43 P12931\n", + "O75553 P46531\n", + "P35222 P46531\n", + "P84022 P46531\n", + "P06239 P46531\n", + "Q13950 P46531\n", + "Q14289 Q05397\n", + "P08581 Q05397\n", + "Q05397 P56945\n", + "Q05397 Q9HD43\n", + "Q9HD43 Q05397\n", + "P12830 P35222\n", + "P08581 P12830\n", + "O60716 P12830\n", + "Q15139 P12830\n", + "P19022 P35222\n", + "O60716 P19022\n", + "Q13177 P08670\n", + "O95819 O43318\n", + "O95819 Q13233\n", + "Q13188 O95835\n", + "Q13043 O95835\n", + "P35240 O95835\n", + "O95835 Q9GZV5\n", + "O95835 P46937\n", + "Q13188 Q9NRM7\n", + "Q13043 Q9NRM7\n", + "P35240 Q9NRM7\n", + "Q9NRM7 Q9GZV5\n", + "Q9NRM7 P46937\n", + "Q15139 P35222\n", + "P46937 P35222\n", + "Q13177 P04049\n", + "Q13177 P35240\n", + "O43318 P45983\n", + "Q13233 P45983\n", + "P45983 Q13043\n", + "P45983 P84022\n", + "O43318 P84022\n", + "P04049 Q13188\n", + "P04049 Q13043\n", + "P06239 P04049\n", + "P35240 Q13188\n", + "P35240 Q13043\n", + "P56945 P84022\n", + "Q9GZV5 P84022\n", + "P84022 Q13950\n", + "Q9HD43 P56945\n", + "Q9HD43 P06239\n", + "Q9GZV5 Q13950\n", + "P46937 Q13950\n", + "looking for paths in the network with length: 0 for node NOTCH1 and LATS2\n", + "looking for paths in the network with length: 1 for node NOTCH1 and LATS2\n", + "looking for paths in the network with length: 2 for node NOTCH1 and LATS2\n", + "looking for paths in the network with length: 3 for node NOTCH1 and LATS2\n", + "Found a path!\n", + "[['NOTCH1', 'SMAD3', 'WWTR1', 'LATS2'], ['NOTCH1', 'CTNNB1', 'YAP1', 'LATS2'], ['NOTCH1', 'RUNX2', 'WWTR1', 'LATS2'], ['NOTCH1', 'RUNX2', 'YAP1', 'LATS2']]\n", + "looking for paths in the network with length: 0 for node NOTCH1 and PTK2B\n", + "looking for paths in the network with length: 1 for node NOTCH1 and PTK2B\n", + "looking for paths in the network with length: 2 for node NOTCH1 and PTK2B\n", + "looking for paths in the network with length: 3 for node NOTCH1 and PTK2B\n", + "looking for paths in the network with length: 4 for node NOTCH1 and PTK2B\n", + "Found a path!\n", + "[['NOTCH1', 'LCK', 'PTPRH', 'PTK2', 'PTK2B'], ['NOTCH1', 'SMAD3', 'BCAR1', 'PTK2', 'PTK2B']]\n", + "looking for paths in the network with length: 0 for node PTK2 and CDH1\n", + "looking for paths in the network with length: 1 for node PTK2 and CDH1\n", + "looking for paths in the network with length: 2 for node PTK2 and CDH1\n", + "looking for paths in the network with length: 3 for node PTK2 and CDH1\n", + "looking for paths in the network with length: 4 for node PTK2 and CDH1\n", + "Found a path!\n", + "[['PTK2', 'PTPRH', 'SRC', 'CTNND1', 'CDH1'], ['PTK2', 'PTPRH', 'SRC', 'MET', 'CDH1'], ['PTK2', 'PTPRH', 'SRC', 'PRKD1', 'CDH1']]\n", + "looking for paths in the network with length: 0 for node PTK2 and CDH2\n", + "looking for paths in the network with length: 1 for node PTK2 and CDH2\n", + "looking for paths in the network with length: 2 for node PTK2 and CDH2\n", + "looking for paths in the network with length: 3 for node PTK2 and CDH2\n", + "Found a path!\n", + "[['PTK2', 'PTPRH', 'SRC', 'CDH2']]\n", + "looking for paths in the network with length: 0 for node PTK2 and VIM\n", + "looking for paths in the network with length: 1 for node PTK2 and VIM\n", + "looking for paths in the network with length: 2 for node PTK2 and VIM\n", + "looking for paths in the network with length: 3 for node PTK2 and VIM\n", + "looking for paths in the network with length: 4 for node PTK2 and VIM\n", + "Found a path!\n", + "[['PTK2', 'PTPRH', 'SRC', 'PAK2', 'VIM']]\n", + "looking for paths in the network with length: 0 for node PTK2 and MAP4K4\n", + "looking for paths in the network with length: 1 for node PTK2 and MAP4K4\n", + "looking for paths in the network with length: 2 for node PTK2 and MAP4K4\n", + "looking for paths in the network with length: 3 for node PTK2 and MAP4K4\n", + "looking for paths in the network with length: 4 for node PTK2 and MAP4K4\n", + "Found a path!\n", + "[['PTK2', 'SRC', 'MAPK8', 'MAP3K1', 'MAP4K4'], ['PTK2', 'SRC', 'MAPK8', 'MAP3K7', 'MAP4K4']]\n", + "looking for paths in the network with length: 0 for node PTK2 and LATS1\n", + "looking for paths in the network with length: 1 for node PTK2 and LATS1\n", + "looking for paths in the network with length: 2 for node PTK2 and LATS1\n", + "looking for paths in the network with length: 3 for node PTK2 and LATS1\n", + "looking for paths in the network with length: 4 for node PTK2 and LATS1\n", + "looking for paths in the network with length: 5 for node PTK2 and LATS1\n", + "Found a path!\n", + "[['PTK2', 'PTPRH', 'LCK', 'RAF1', 'STK3', 'LATS1'], ['PTK2', 'PTPRH', 'LCK', 'RAF1', 'STK4', 'LATS1'], ['PTK2', 'PTPRH', 'SRC', 'RAF1', 'STK3', 'LATS1'], ['PTK2', 'PTPRH', 'SRC', 'RAF1', 'STK4', 'LATS1'], ['PTK2', 'PTPRH', 'SRC', 'PAK2', 'NF2', 'LATS1']]\n", + "looking for paths in the network with length: 0 for node PTK2 and LATS2\n", + "looking for paths in the network with length: 1 for node PTK2 and LATS2\n", + "looking for paths in the network with length: 2 for node PTK2 and LATS2\n", + "looking for paths in the network with length: 3 for node PTK2 and LATS2\n", + "looking for paths in the network with length: 4 for node PTK2 and LATS2\n", + "looking for paths in the network with length: 5 for node PTK2 and LATS2\n", + "Found a path!\n", + "[['PTK2', 'PTPRH', 'LCK', 'RAF1', 'STK3', 'LATS2'], ['PTK2', 'PTPRH', 'LCK', 'RAF1', 'STK4', 'LATS2'], ['PTK2', 'PTPRH', 'SRC', 'RAF1', 'STK3', 'LATS2'], ['PTK2', 'PTPRH', 'SRC', 'RAF1', 'STK4', 'LATS2'], ['PTK2', 'PTPRH', 'SRC', 'PAK2', 'NF2', 'LATS2']]\n", + "looking for paths in the network with length: 0 for node PTK2 and PTK2B\n", + "looking for paths in the network with length: 1 for node PTK2 and PTK2B\n", + "Found a path!\n", + "[['PTK2', 'PTK2B']]\n", + "looking for paths in the network with length: 0 for node CDH1 and CDH2\n", + "looking for paths in the network with length: 1 for node CDH1 and CDH2\n", + "looking for paths in the network with length: 2 for node CDH1 and CDH2\n", + "looking for paths in the network with length: 3 for node CDH1 and CDH2\n", + "looking for paths in the network with length: 4 for node CDH1 and CDH2\n", + "looking for paths in the network with length: 5 for node CDH1 and CDH2\n", + "looking for paths in the network with length: 6 for node CDH1 and CDH2\n", + "i_search = 3\n", + "Looking for paths with length: 0 for node CDH1 and CDH2\n", + "i_search = 3\n", + "Looking for paths with length: 1 for node CDH1 and CDH2\n", + "i_search = 3\n", + "Looking for paths with length: 2 for node CDH1 and CDH2\n", + "i_search = 3\n", + "Looking for paths with length: 3 for node CDH1 and CDH2\n", + "[['CDH1', 'EGFR', 'CTNND1', 'CDH2']]\n", + "P12830 P00533\n", + "P00533 O60716\n", + "O60716 P19022\n", + "P12931 Q05397\n", + "P12931 P19022\n", + "P12931 Q14289\n", + "P12931 O75553\n", + "P12931 P35222\n", + "P12931 P08581\n", + "P12931 O60716\n", + "P12931 Q15139\n", + "P12931 Q13177\n", + "P45983 P12931\n", + "P12931 P04049\n", + "P12931 P56945\n", + "Q9HD43 P12931\n", + "P12931 P00533\n", + "O75553 P46531\n", + "P35222 P46531\n", + "P84022 P46531\n", + "P06239 P46531\n", + "Q13950 P46531\n", + "Q14289 Q05397\n", + "P08581 Q05397\n", + "Q05397 P56945\n", + "Q05397 Q9HD43\n", + "Q9HD43 Q05397\n", + "P00533 Q05397\n", + "P12830 P35222\n", + "P08581 P12830\n", + "O60716 P12830\n", + "Q15139 P12830\n", + "P12830 P00533\n", + "P19022 P35222\n", + "O60716 P19022\n", + "Q13177 P08670\n", + "O95819 O43318\n", + "O95819 Q13233\n", + "Q13188 O95835\n", + "Q13043 O95835\n", + "P35240 O95835\n", + "O95835 Q9GZV5\n", + "O95835 P46937\n", + "Q13188 Q9NRM7\n", + "Q13043 Q9NRM7\n", + "P35240 Q9NRM7\n", + "Q9NRM7 Q9GZV5\n", + "Q9NRM7 P46937\n", + "Q14289 P00533\n", + "Q15139 P35222\n", + "P46937 P35222\n", + "P00533 P35222\n", + "P00533 O60716\n", + "Q15139 P00533\n", + "Q13177 P04049\n", + "Q13177 P35240\n", + "O43318 P45983\n", + "Q13233 P45983\n", + "P45983 Q13043\n", + "P45983 P84022\n", + "O43318 P84022\n", + "P04049 Q13188\n", + "P04049 Q13043\n", + "P06239 P04049\n", + "P35240 Q13188\n", + "P35240 Q13043\n", + "P56945 P84022\n", + "Q9GZV5 P84022\n", + "P84022 Q13950\n", + "Q9HD43 P56945\n", + "P00533 P56945\n", + "Q9HD43 P06239\n", + "Q9GZV5 Q13950\n", + "P46937 Q13950\n", + "looking for paths in the network with length: 0 for node CDH1 and VIM\n", + "looking for paths in the network with length: 1 for node CDH1 and VIM\n", + "looking for paths in the network with length: 2 for node CDH1 and VIM\n", + "looking for paths in the network with length: 3 for node CDH1 and VIM\n", + "looking for paths in the network with length: 4 for node CDH1 and VIM\n", + "looking for paths in the network with length: 5 for node CDH1 and VIM\n", + "looking for paths in the network with length: 6 for node CDH1 and VIM\n", + "Found a path!\n", + "[['CDH1', 'EGFR', 'PTK2', 'PTPRH', 'SRC', 'PAK2', 'VIM']]\n", + "looking for paths in the network with length: 0 for node CDH1 and MAP4K4\n", + "looking for paths in the network with length: 1 for node CDH1 and MAP4K4\n", + "looking for paths in the network with length: 2 for node CDH1 and MAP4K4\n", + "looking for paths in the network with length: 3 for node CDH1 and MAP4K4\n", + "looking for paths in the network with length: 4 for node CDH1 and MAP4K4\n", + "looking for paths in the network with length: 5 for node CDH1 and MAP4K4\n", + "Found a path!\n", + "[['CDH1', 'MET', 'SRC', 'MAPK8', 'MAP3K1', 'MAP4K4'], ['CDH1', 'MET', 'SRC', 'MAPK8', 'MAP3K7', 'MAP4K4'], ['CDH1', 'CTNND1', 'SRC', 'MAPK8', 'MAP3K1', 'MAP4K4'], ['CDH1', 'CTNND1', 'SRC', 'MAPK8', 'MAP3K7', 'MAP4K4'], ['CDH1', 'PRKD1', 'SRC', 'MAPK8', 'MAP3K1', 'MAP4K4'], ['CDH1', 'PRKD1', 'SRC', 'MAPK8', 'MAP3K7', 'MAP4K4']]\n", + "looking for paths in the network with length: 0 for node CDH1 and LATS1\n", + "looking for paths in the network with length: 1 for node CDH1 and LATS1\n", + "looking for paths in the network with length: 2 for node CDH1 and LATS1\n", + "looking for paths in the network with length: 3 for node CDH1 and LATS1\n", + "looking for paths in the network with length: 4 for node CDH1 and LATS1\n", + "looking for paths in the network with length: 5 for node CDH1 and LATS1\n", + "looking for paths in the network with length: 6 for node CDH1 and LATS1\n", + "i_search = 3\n", + "Looking for paths with length: 0 for node CDH1 and LATS1\n", + "i_search = 3\n", + "Looking for paths with length: 1 for node CDH1 and LATS1\n", + "i_search = 3\n", + "Looking for paths with length: 2 for node CDH1 and LATS1\n", + "i_search = 3\n", + "Looking for paths with length: 3 for node CDH1 and LATS1\n", + "looking for paths in the network with length: 0 for node CDH1 and LATS2\n", + "looking for paths in the network with length: 1 for node CDH1 and LATS2\n", + "looking for paths in the network with length: 2 for node CDH1 and LATS2\n", + "looking for paths in the network with length: 3 for node CDH1 and LATS2\n", + "looking for paths in the network with length: 4 for node CDH1 and LATS2\n", + "looking for paths in the network with length: 5 for node CDH1 and LATS2\n", + "looking for paths in the network with length: 6 for node CDH1 and LATS2\n", + "i_search = 3\n", + "Looking for paths with length: 0 for node CDH1 and LATS2\n", + "i_search = 3\n", + "Looking for paths with length: 1 for node CDH1 and LATS2\n", + "i_search = 3\n", + "Looking for paths with length: 2 for node CDH1 and LATS2\n", + "i_search = 3\n", + "Looking for paths with length: 3 for node CDH1 and LATS2\n", + "looking for paths in the network with length: 0 for node CDH1 and PTK2B\n", + "looking for paths in the network with length: 1 for node CDH1 and PTK2B\n", + "looking for paths in the network with length: 2 for node CDH1 and PTK2B\n", + "looking for paths in the network with length: 3 for node CDH1 and PTK2B\n", + "Found a path!\n", + "[['CDH1', 'CTNND1', 'EGFR', 'PTK2B']]\n", + "looking for paths in the network with length: 0 for node CDH2 and VIM\n", + "looking for paths in the network with length: 1 for node CDH2 and VIM\n", + "looking for paths in the network with length: 2 for node CDH2 and VIM\n", + "looking for paths in the network with length: 3 for node CDH2 and VIM\n", + "looking for paths in the network with length: 4 for node CDH2 and VIM\n", + "looking for paths in the network with length: 5 for node CDH2 and VIM\n", + "looking for paths in the network with length: 6 for node CDH2 and VIM\n", + "i_search = 3\n", + "Looking for paths with length: 0 for node CDH2 and VIM\n", + "i_search = 3\n", + "Looking for paths with length: 1 for node CDH2 and VIM\n", + "i_search = 3\n", + "Looking for paths with length: 2 for node CDH2 and VIM\n", + "i_search = 3\n", + "Looking for paths with length: 3 for node CDH2 and VIM\n", + "looking for paths in the network with length: 0 for node CDH2 and MAP4K4\n", + "looking for paths in the network with length: 1 for node CDH2 and MAP4K4\n", + "looking for paths in the network with length: 2 for node CDH2 and MAP4K4\n", + "looking for paths in the network with length: 3 for node CDH2 and MAP4K4\n", + "looking for paths in the network with length: 4 for node CDH2 and MAP4K4\n", + "Found a path!\n", + "[['CDH2', 'SRC', 'MAPK8', 'MAP3K1', 'MAP4K4'], ['CDH2', 'SRC', 'MAPK8', 'MAP3K7', 'MAP4K4']]\n", + "looking for paths in the network with length: 0 for node CDH2 and LATS1\n", + "looking for paths in the network with length: 1 for node CDH2 and LATS1\n", + "looking for paths in the network with length: 2 for node CDH2 and LATS1\n", + "looking for paths in the network with length: 3 for node CDH2 and LATS1\n", + "looking for paths in the network with length: 4 for node CDH2 and LATS1\n", + "looking for paths in the network with length: 5 for node CDH2 and LATS1\n", + "looking for paths in the network with length: 6 for node CDH2 and LATS1\n", + "i_search = 3\n", + "Looking for paths with length: 0 for node CDH2 and LATS1\n", + "i_search = 3\n", + "Looking for paths with length: 1 for node CDH2 and LATS1\n", + "i_search = 3\n", + "Looking for paths with length: 2 for node CDH2 and LATS1\n", + "i_search = 3\n", + "Looking for paths with length: 3 for node CDH2 and LATS1\n", + "looking for paths in the network with length: 0 for node CDH2 and LATS2\n", + "looking for paths in the network with length: 1 for node CDH2 and LATS2\n", + "looking for paths in the network with length: 2 for node CDH2 and LATS2\n", + "looking for paths in the network with length: 3 for node CDH2 and LATS2\n", + "looking for paths in the network with length: 4 for node CDH2 and LATS2\n", + "looking for paths in the network with length: 5 for node CDH2 and LATS2\n", + "looking for paths in the network with length: 6 for node CDH2 and LATS2\n", + "i_search = 3\n", + "Looking for paths with length: 0 for node CDH2 and LATS2\n", + "i_search = 3\n", + "Looking for paths with length: 1 for node CDH2 and LATS2\n", + "i_search = 3\n", + "Looking for paths with length: 2 for node CDH2 and LATS2\n", + "i_search = 3\n", + "Looking for paths with length: 3 for node CDH2 and LATS2\n", + "looking for paths in the network with length: 0 for node CDH2 and PTK2B\n", + "looking for paths in the network with length: 1 for node CDH2 and PTK2B\n", + "looking for paths in the network with length: 2 for node CDH2 and PTK2B\n", + "looking for paths in the network with length: 3 for node CDH2 and PTK2B\n", + "Found a path!\n", + "[['CDH2', 'CTNND1', 'EGFR', 'PTK2B']]\n", + "looking for paths in the network with length: 0 for node VIM and MAP4K4\n", + "looking for paths in the network with length: 1 for node VIM and MAP4K4\n", + "looking for paths in the network with length: 2 for node VIM and MAP4K4\n", + "looking for paths in the network with length: 3 for node VIM and MAP4K4\n", + "looking for paths in the network with length: 4 for node VIM and MAP4K4\n", + "looking for paths in the network with length: 5 for node VIM and MAP4K4\n", + "Found a path!\n", + "[['VIM', 'PAK2', 'SRC', 'MAPK8', 'MAP3K1', 'MAP4K4'], ['VIM', 'PAK2', 'SRC', 'MAPK8', 'MAP3K7', 'MAP4K4']]\n", + "looking for paths in the network with length: 0 for node VIM and LATS1\n", + "looking for paths in the network with length: 1 for node VIM and LATS1\n", + "looking for paths in the network with length: 2 for node VIM and LATS1\n", + "looking for paths in the network with length: 3 for node VIM and LATS1\n", + "looking for paths in the network with length: 4 for node VIM and LATS1\n", + "looking for paths in the network with length: 5 for node VIM and LATS1\n", + "looking for paths in the network with length: 6 for node VIM and LATS1\n", + "i_search = 3\n", + "Looking for paths with length: 0 for node VIM and LATS1\n", + "i_search = 3\n", + "Looking for paths with length: 1 for node VIM and LATS1\n", + "i_search = 3\n", + "Looking for paths with length: 2 for node VIM and LATS1\n", + "i_search = 3\n", + "Looking for paths with length: 3 for node VIM and LATS1\n", + "looking for paths in the network with length: 0 for node VIM and LATS2\n", + "looking for paths in the network with length: 1 for node VIM and LATS2\n", + "looking for paths in the network with length: 2 for node VIM and LATS2\n", + "looking for paths in the network with length: 3 for node VIM and LATS2\n", + "looking for paths in the network with length: 4 for node VIM and LATS2\n", + "looking for paths in the network with length: 5 for node VIM and LATS2\n", + "looking for paths in the network with length: 6 for node VIM and LATS2\n", + "i_search = 3\n", + "Looking for paths with length: 0 for node VIM and LATS2\n", + "i_search = 3\n", + "Looking for paths with length: 1 for node VIM and LATS2\n", + "i_search = 3\n", + "Looking for paths with length: 2 for node VIM and LATS2\n", + "i_search = 3\n", + "Looking for paths with length: 3 for node VIM and LATS2\n", + "looking for paths in the network with length: 0 for node VIM and PTK2B\n", + "looking for paths in the network with length: 1 for node VIM and PTK2B\n", + "looking for paths in the network with length: 2 for node VIM and PTK2B\n", + "looking for paths in the network with length: 3 for node VIM and PTK2B\n", + "looking for paths in the network with length: 4 for node VIM and PTK2B\n", + "looking for paths in the network with length: 5 for node VIM and PTK2B\n", + "Found a path!\n", + "[['VIM', 'PAK2', 'SRC', 'PTPRH', 'PTK2', 'PTK2B']]\n", + "looking for paths in the network with length: 0 for node MAP4K4 and LATS1\n", + "looking for paths in the network with length: 1 for node MAP4K4 and LATS1\n", + "looking for paths in the network with length: 2 for node MAP4K4 and LATS1\n", + "looking for paths in the network with length: 3 for node MAP4K4 and LATS1\n", + "looking for paths in the network with length: 4 for node MAP4K4 and LATS1\n", + "Found a path!\n", + "[['MAP4K4', 'MAP3K1', 'MAPK8', 'STK4', 'LATS1'], ['MAP4K4', 'MAP3K7', 'MAPK8', 'STK4', 'LATS1']]\n", + "looking for paths in the network with length: 0 for node MAP4K4 and LATS2\n", + "looking for paths in the network with length: 1 for node MAP4K4 and LATS2\n", + "looking for paths in the network with length: 2 for node MAP4K4 and LATS2\n", + "looking for paths in the network with length: 3 for node MAP4K4 and LATS2\n", + "looking for paths in the network with length: 4 for node MAP4K4 and LATS2\n", + "Found a path!\n", + "[['MAP4K4', 'MAP3K1', 'MAPK8', 'STK4', 'LATS2'], ['MAP4K4', 'MAP3K7', 'MAPK8', 'STK4', 'LATS2']]\n", + "looking for paths in the network with length: 0 for node MAP4K4 and PTK2B\n", + "looking for paths in the network with length: 1 for node MAP4K4 and PTK2B\n", + "looking for paths in the network with length: 2 for node MAP4K4 and PTK2B\n", + "looking for paths in the network with length: 3 for node MAP4K4 and PTK2B\n", + "looking for paths in the network with length: 4 for node MAP4K4 and PTK2B\n", + "Found a path!\n", + "[['MAP4K4', 'MAP3K1', 'MAPK8', 'SRC', 'PTK2B'], ['MAP4K4', 'MAP3K7', 'MAPK8', 'SRC', 'PTK2B']]\n", + "looking for paths in the network with length: 0 for node LATS1 and LATS2\n", + "looking for paths in the network with length: 1 for node LATS1 and LATS2\n", + "looking for paths in the network with length: 2 for node LATS1 and LATS2\n", + "looking for paths in the network with length: 3 for node LATS1 and LATS2\n", + "looking for paths in the network with length: 4 for node LATS1 and LATS2\n", + "looking for paths in the network with length: 5 for node LATS1 and LATS2\n", + "looking for paths in the network with length: 6 for node LATS1 and LATS2\n", + "i_search = 3\n", + "Looking for paths with length: 0 for node LATS1 and LATS2\n", + "i_search = 3\n", + "Looking for paths with length: 1 for node LATS1 and LATS2\n", + "i_search = 3\n", + "Looking for paths with length: 2 for node LATS1 and LATS2\n", + "i_search = 3\n", + "Looking for paths with length: 3 for node LATS1 and LATS2\n", + "looking for paths in the network with length: 0 for node LATS1 and PTK2B\n", + "looking for paths in the network with length: 1 for node LATS1 and PTK2B\n", + "looking for paths in the network with length: 2 for node LATS1 and PTK2B\n", + "looking for paths in the network with length: 3 for node LATS1 and PTK2B\n", + "looking for paths in the network with length: 4 for node LATS1 and PTK2B\n", + "looking for paths in the network with length: 5 for node LATS1 and PTK2B\n", + "looking for paths in the network with length: 6 for node LATS1 and PTK2B\n", + "Found a path!\n", + "[['LATS1', 'NF2', 'PAK2', 'SRC', 'PTPRH', 'PTK2', 'PTK2B'], ['LATS1', 'STK3', 'RAF1', 'LCK', 'PTPRH', 'PTK2', 'PTK2B'], ['LATS1', 'STK3', 'RAF1', 'SRC', 'PTPRH', 'PTK2', 'PTK2B'], ['LATS1', 'STK4', 'RAF1', 'LCK', 'PTPRH', 'PTK2', 'PTK2B'], ['LATS1', 'STK4', 'RAF1', 'SRC', 'PTPRH', 'PTK2', 'PTK2B']]\n", + "looking for paths in the network with length: 0 for node LATS2 and PTK2B\n", + "looking for paths in the network with length: 1 for node LATS2 and PTK2B\n", + "looking for paths in the network with length: 2 for node LATS2 and PTK2B\n", + "looking for paths in the network with length: 3 for node LATS2 and PTK2B\n", + "looking for paths in the network with length: 4 for node LATS2 and PTK2B\n", + "looking for paths in the network with length: 5 for node LATS2 and PTK2B\n", + "looking for paths in the network with length: 6 for node LATS2 and PTK2B\n", + "Found a path!\n", + "[['LATS2', 'NF2', 'PAK2', 'SRC', 'PTPRH', 'PTK2', 'PTK2B'], ['LATS2', 'STK3', 'RAF1', 'LCK', 'PTPRH', 'PTK2', 'PTK2B'], ['LATS2', 'STK3', 'RAF1', 'SRC', 'PTPRH', 'PTK2', 'PTK2B'], ['LATS2', 'STK4', 'RAF1', 'LCK', 'PTPRH', 'PTK2', 'PTK2B'], ['LATS2', 'STK4', 'RAF1', 'SRC', 'PTPRH', 'PTK2', 'PTK2B']]\n", + "CPU times: user 3min 17s, sys: 199 ms, total: 3min 17s\n", + "Wall time: 3min 17s\n" + ] + } + ], + "source": [ + "%%time\n", + "new_net1.complete_connection(mode=\"ALL\", maxlen=6, k_mean=\"tight\", only_signed=True, connect_node_when_first_introduced=True, consensus=True)" + ] + }, + { + "cell_type": "markdown", + "id": "c6510316-2f47-4e71-89e0-b93da0657897", + "metadata": {}, + "source": [ + "#### 4E. Visualize final network" + ] + }, + { + "cell_type": "code", + "execution_count": 13, + "id": "152b9434", + "metadata": {}, + "outputs": [ + { + "data": { + "image/svg+xml": [ + "\n", + "\n", + "\n", + "\n", + "\n", + "\n", + "%3\n", + "\n", + "\n", + "\n", + "SRC\n", + "\n", + "SRC\n", + "\n", + "\n", + "\n", + "PTK2\n", + "\n", + "PTK2\n", + "\n", + "\n", + "\n", + "SRC->PTK2\n", + "\n", + "\n", + "\n", + "\n", + "\n", + "CDH2\n", + "\n", + "CDH2\n", + "\n", + "\n", + "\n", + "SRC->CDH2\n", + "\n", + "\n", + "\n", + "\n", + "\n", + "\n", + "PTK2B\n", + "\n", + "PTK2B\n", + "\n", + "\n", + "\n", + "SRC->PTK2B\n", + "\n", + "\n", + "\n", + "\n", + "\n", + "DAB1\n", + "\n", + "DAB1\n", + "\n", + "\n", + "\n", + "SRC->DAB1\n", + "\n", + "\n", + "\n", + "\n", + "\n", + "CTNNB1\n", + "\n", + "CTNNB1\n", + "\n", + "\n", + "\n", + "SRC->CTNNB1\n", + "\n", + "\n", + "\n", + "\n", + "\n", + "MET\n", + "\n", + "MET\n", + "\n", + "\n", + "\n", + "SRC->MET\n", + "\n", + "\n", + "\n", + "\n", + "\n", + "\n", + "CTNND1\n", + "\n", + "CTNND1\n", + "\n", + "\n", + "\n", + "SRC->CTNND1\n", + "\n", + "\n", + "\n", + "\n", + "\n", + "PRKD1\n", + "\n", + "PRKD1\n", + "\n", + "\n", + "\n", + "SRC->PRKD1\n", + "\n", + "\n", + "\n", + "\n", + "\n", + "PAK2\n", + "\n", + "PAK2\n", + "\n", + "\n", + "\n", + "SRC->PAK2\n", + "\n", + "\n", + "\n", + "\n", + "\n", + "RAF1\n", + "\n", + "RAF1\n", + "\n", + "\n", + "\n", + "SRC->RAF1\n", + "\n", + "\n", + "\n", + "\n", + "\n", + "BCAR1\n", + "\n", + "BCAR1\n", + "\n", + "\n", + "\n", + "SRC->BCAR1\n", + "\n", + "\n", + "\n", + "\n", + "\n", + "EGFR\n", + "\n", + "EGFR\n", + "\n", + "\n", + "\n", + "SRC->EGFR\n", + "\n", + "\n", + "\n", + "\n", + "\n", + "PTK2->BCAR1\n", + "\n", + "\n", + "\n", + "\n", + "\n", + "PTPRH\n", + "\n", + "PTPRH\n", + "\n", + "\n", + "\n", + "PTK2->PTPRH\n", + "\n", + "\n", + "\n", + "\n", + "\n", + "\n", + "CDH2->CTNNB1\n", + "\n", + "\n", + "\n", + "\n", + "\n", + "PTK2B->PTK2\n", + "\n", + "\n", + "\n", + "\n", + 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"\n", + "\n", + "NF2\n", + "\n", + "NF2\n", + "\n", + "\n", + "\n", + "PAK2->NF2\n", + "\n", + "\n", + "\n", + "\n", + "\n", + "MAPK8\n", + "\n", + "MAPK8\n", + "\n", + "\n", + "\n", + "MAPK8->SRC\n", + "\n", + "\n", + "\n", + "\n", + "\n", + "STK4\n", + "\n", + "STK4\n", + "\n", + "\n", + "\n", + "MAPK8->STK4\n", + "\n", + "\n", + "\n", + "\n", + "\n", + "SMAD3\n", + "\n", + "SMAD3\n", + "\n", + "\n", + "\n", + "MAPK8->SMAD3\n", + "\n", + "\n", + "\n", + "\n", + "\n", + "MAP3K7\n", + "\n", + "MAP3K7\n", + "\n", + "\n", + "\n", + "MAP3K7->MAPK8\n", + "\n", + "\n", + "\n", + "\n", + "\n", + "MAP3K7->SMAD3\n", + "\n", + "\n", + "\n", + "\n", + "\n", + "\n", + "MAP4K4\n", + "\n", + "MAP4K4\n", + "\n", + "\n", + "\n", + "MAP4K4->MAP3K7\n", + "\n", + "\n", + "\n", + "\n", + "\n", + "MAP3K1\n", + "\n", + "MAP3K1\n", + "\n", + "\n", + "\n", + "MAP4K4->MAP3K1\n", + "\n", + "\n", + "\n", + "\n", + "\n", + "MAP3K1->MAPK8\n", + "\n", + "\n", + "\n", + "\n", + "\n", + "STK3\n", + "\n", + "STK3\n", + "\n", + "\n", + "\n", + "RAF1->STK3\n", + "\n", + "\n", + "\n", + "\n", + "\n", + "\n", + "RAF1->STK4\n", + "\n", + "\n", + "\n", + "\n", + "\n", + "\n", + "LATS1\n", + "\n", + "LATS1\n", + "\n", + "\n", + "\n", + "STK3->LATS1\n", + "\n", + "\n", + "\n", + "\n", + "\n", + "LATS2\n", + "\n", + "LATS2\n", + "\n", + "\n", + "\n", + "STK3->LATS2\n", + "\n", + "\n", + "\n", + "\n", + "\n", + "WWTR1\n", + "\n", + "WWTR1\n", + "\n", + "\n", + "\n", + "LATS1->WWTR1\n", + "\n", + "\n", + "\n", + "\n", + "\n", + "\n", + "YAP1\n", + "\n", + "YAP1\n", + "\n", + "\n", + "\n", + "LATS1->YAP1\n", + "\n", + "\n", + "\n", + "\n", + "\n", + "STK4->LATS1\n", + "\n", + "\n", + "\n", + "\n", + "\n", + "STK4->LATS2\n", + "\n", + "\n", + "\n", + "\n", + "\n", + "NF2->STK3\n", + "\n", + "\n", + "\n", + "\n", + "\n", + "NF2->LATS1\n", + "\n", + "\n", + "\n", + "\n", + "\n", + "NF2->STK4\n", + "\n", + "\n", + "\n", + "\n", + "\n", + "NF2->LATS2\n", + "\n", + "\n", + "\n", + "\n", + "\n", + "LATS2->WWTR1\n", + "\n", + "\n", + "\n", + "\n", + "\n", + "\n", + "LATS2->YAP1\n", + "\n", + "\n", + "\n", + "\n", + "\n", + "\n", + "SMAD3->NOTCH1\n", + "\n", + "\n", + "\n", + "\n", + "\n", + "RUNX2\n", + "\n", + "RUNX2\n", + "\n", + "\n", + "\n", + "SMAD3->RUNX2\n", + "\n", + "\n", + "\n", + "\n", + "\n", + "\n", + "BCAR1->SMAD3\n", + "\n", + "\n", + "\n", + "\n", + "\n", + "\n", + "LCK\n", + "\n", + "LCK\n", + "\n", + "\n", + "\n", + "LCK->NOTCH1\n", + "\n", + "\n", + "\n", + "\n", + "\n", + "LCK->RAF1\n", + "\n", + "\n", + "\n", + "\n", + "\n", + "PTPRH->SRC\n", + "\n", + "\n", + "\n", + "\n", + "\n", + "\n", + "PTPRH->PTK2\n", + "\n", + "\n", + "\n", + "\n", + "\n", + "\n", + "PTPRH->BCAR1\n", + "\n", + "\n", + "\n", + "\n", + "\n", + "\n", + "PTPRH->LCK\n", + "\n", + "\n", + "\n", + "\n", + "\n", + "\n", + "WWTR1->SMAD3\n", + "\n", + "\n", + "\n", + "\n", + "\n", + "WWTR1->RUNX2\n", + "\n", + "\n", + "\n", + "\n", + "\n", + "RUNX2->NOTCH1\n", + "\n", + "\n", + "\n", + "\n", + "\n", + "\n", + "YAP1->CTNNB1\n", + "\n", + "\n", + "\n", + "\n", + "\n", + "YAP1->RUNX2\n", + "\n", + "\n", + "\n", + "\n", + "\n", + "\n", + "EGFR->PTK2\n", + "\n", + "\n", + "\n", + "\n", + "\n", + "EGFR->CTNNB1\n", + "\n", + "\n", + "\n", + "\n", + "\n", + "EGFR->CTNND1\n", + "\n", + "\n", + "\n", + "\n", + "\n", + "\n", + "EGFR->BCAR1\n", + "\n", + "\n", + "\n", + "\n", + "\n", + "\n" + ], + "text/plain": [ + "" + ] + }, + "metadata": {}, + "output_type": "display_data" + } + ], + "source": [ + "#Visualize network\n", + "visualizer1 = NetworkVisualizer(new_net1, color_by='effect')\n", + "visualizer1.render(output_file='network2')" + ] + }, + { + "cell_type": "code", + "execution_count": 14, + "id": "80b84e81-abc2-4aae-ad1c-3ebf00355b98", + "metadata": {}, + "outputs": [ + { + "data": { + "image/svg+xml": [ + "\n", + "\n", + "\n", + "\n", + "\n", + "\n", + "%3\n", + "\n", + "\n", + "\n", + "SRC\n", + "\n", + "SRC\n", + "\n", + "\n", + "\n", + "PTK2\n", + "\n", + "PTK2\n", + "\n", + "\n", + "\n", + "SRC->PTK2\n", + "\n", + "\n", + "\n", + "\n", + "\n", + "CDH2\n", + "\n", + "CDH2\n", + "\n", + "\n", + "\n", + "SRC->CDH2\n", + "\n", + "\n", + "\n", + "\n", + "\n", + "\n", + "PTK2B\n", + "\n", + "PTK2B\n", + "\n", + "\n", + "\n", + "SRC->PTK2B\n", + "\n", + "\n", + "\n", + "\n", + "\n", + "DAB1\n", + "\n", + "DAB1\n", + "\n", + "\n", + "\n", + "SRC->DAB1\n", + "\n", + "\n", + "\n", + "\n", + "\n", + "CTNNB1\n", + "\n", + "CTNNB1\n", + "\n", + "\n", + "\n", + "SRC->CTNNB1\n", + "\n", + "\n", + "\n", + "\n", + "\n", + "MET\n", + "\n", + "MET\n", + "\n", + "\n", + "\n", + "SRC->MET\n", + "\n", + "\n", + "\n", + "\n", + "\n", + "\n", + "CTNND1\n", + "\n", + "CTNND1\n", + "\n", + "\n", + "\n", + "SRC->CTNND1\n", + "\n", + "\n", + "\n", + "\n", + "\n", + "PRKD1\n", + "\n", + "PRKD1\n", + "\n", + "\n", + "\n", + "SRC->PRKD1\n", + "\n", + "\n", + "\n", + "\n", + "\n", + "PAK2\n", + "\n", + "PAK2\n", + "\n", + "\n", + "\n", + "SRC->PAK2\n", + "\n", + "\n", + "\n", + "\n", + "\n", + "RAF1\n", + "\n", + "RAF1\n", + "\n", + "\n", + "\n", + "SRC->RAF1\n", + "\n", + "\n", + "\n", + "\n", + "\n", + "BCAR1\n", + "\n", + "BCAR1\n", + "\n", + "\n", + "\n", + "SRC->BCAR1\n", + "\n", + "\n", + "\n", + "\n", + "\n", + "EGFR\n", + "\n", + "EGFR\n", + "\n", + "\n", + "\n", + "SRC->EGFR\n", + "\n", + "\n", + "\n", + "\n", + "\n", + "MAPK8\n", + "\n", + "MAPK8\n", + "\n", + "\n", + "\n", + "MAPK8->SRC\n", + "\n", + "\n", + "\n", + "\n", + "\n", + "PTPRH\n", + "\n", + "PTPRH\n", + "\n", + "\n", + "\n", + "PTPRH->SRC\n", + "\n", + "\n", + "\n", + "\n", + "\n", + "\n" + ], + "text/plain": [ + "" + ] + }, + "metadata": {}, + "output_type": "display_data" + } + ], + "source": [ + "#Visualize a specific nodes and \n", + "visualizer1 = NetworkVisualizer(new_net1, predefined_node = \"SRC\",color_by='effect')\n", + "visualizer1.render(output_file='network2')" + ] + }, + { + "cell_type": "code", + "execution_count": 15, + "id": "0aa6d076-5310-462e-aa0e-f69da822b962", + "metadata": {}, + 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sourcetargetTypeEffectReferences
6821P12931Q05397NonestimulationAdhesome:10085298;Adhesome:10592173;Adhesome:1...
32968P12931P19022NoneinhibitionACSN:15782139;ACSN:16371504;ACSN:16492141;ACSN...
5154P12931Q14289NonestimulationAdhesome:10329689;Adhesome:10521452;Adhesome:1...
44795Q14289Q05397NonestimulationAdhesome:16760434;HPRD:16760434;KEA:12960434;K...
38417P12931O75553NonestimulationHPRD-phos:10959835;HPRD-phos:11279201;HPRD:109...
..................
67482P00533Q05397NonestimulationACSN:10545505;ACSN:16919435;ACSN:17496910;ACSN...
7631Q14289P00533NonestimulationCA1:11274221;HPRD:10777553;InnateDB:14963038;S...
73973P00533P35222NonestimulationACSN:12040186;ACSN:14585353;ACSN:17496910;ACSN...
2907Q15139P00533NonestimulationCancerCellMap:10523301;CancerCellMap:2984676;C...
78053P00533P56945NoneinhibitionKEA:17570479;ProtMapper:15951569;SPIKE_LC:1714...
\n", + "

71 rows × 5 columns

\n", + "
" + ], + "text/plain": [ + " source target Type Effect \\\n", + "6821 P12931 Q05397 None stimulation \n", + "32968 P12931 P19022 None inhibition \n", + "5154 P12931 Q14289 None stimulation \n", + "44795 Q14289 Q05397 None stimulation \n", + "38417 P12931 O75553 None stimulation \n", + "... ... ... ... ... \n", + "67482 P00533 Q05397 None stimulation \n", + "7631 Q14289 P00533 None stimulation \n", + "73973 P00533 P35222 None stimulation \n", + "2907 Q15139 P00533 None stimulation \n", + "78053 P00533 P56945 None inhibition \n", + "\n", + " References \n", + "6821 Adhesome:10085298;Adhesome:10592173;Adhesome:1... \n", + "32968 ACSN:15782139;ACSN:16371504;ACSN:16492141;ACSN... \n", + "5154 Adhesome:10329689;Adhesome:10521452;Adhesome:1... \n", + "44795 Adhesome:16760434;HPRD:16760434;KEA:12960434;K... \n", + "38417 HPRD-phos:10959835;HPRD-phos:11279201;HPRD:109... \n", + "... ... \n", + "67482 ACSN:10545505;ACSN:16919435;ACSN:17496910;ACSN... \n", + "7631 CA1:11274221;HPRD:10777553;InnateDB:14963038;S... \n", + "73973 ACSN:12040186;ACSN:14585353;ACSN:17496910;ACSN... \n", + "2907 CancerCellMap:10523301;CancerCellMap:2984676;C... \n", + "78053 KEA:17570479;ProtMapper:15951569;SPIKE_LC:1714... \n", + "\n", + "[71 rows x 5 columns]" + ] + }, + "execution_count": 15, + "metadata": {}, + "output_type": "execute_result" + } + ], + "source": [ + "#We can access to the edges of the network\n", + "new_net1.edges" + ] + }, + { + "cell_type": "markdown", + "id": "ece16ef7-cf9f-4f50-ad5f-99568bdfec88", + "metadata": {}, + "source": [ + "## Adding a public database\n", + "\n", + "The whole tool, as the name suggest, is based on Omnipath. But the user can also integrate its own databases. \n", + "\n", + "As example, we show how to integrate the Signor database. In order to do so, the User needs to have already downloaded the whole Signor database, available at the following link: https://signor.uniroma2.it/downloads.php " + ] + }, + { + "cell_type": "markdown", + "id": "8361d2b2-646b-4080-bc36-ca28c9bfab10", + "metadata": {}, + "source": [ + "### Add Signor database\n", + "\n" + ] + }, + { + "cell_type": "code", + "execution_count": 17, + "id": "5c74dc75-f9f2-4aa8-a9db-04e573bc04b3", + "metadata": {}, + "outputs": [ + { + "data": { + "text/plain": [ + "('singor_db', )" + ] + }, + "execution_count": 17, + "metadata": {}, + "output_type": "execute_result" + } + ], + "source": [ + "from urllib.request import urlretrieve\n", + "url = \"https://signor.uniroma2.it/getData.php?organism=9606\"\n", + "urlretrieve(url, \"singor_db\")" + ] + }, + { + "cell_type": "code", + "execution_count": 16, + "id": "4fd4b190-350a-4682-8f09-8c6423064038", + "metadata": {}, + "outputs": [ + { + "ename": "FileNotFoundError", + "evalue": "[Errno 2] No such file or directory: './all_data_18_03_24.tsv'", + "output_type": "error", + "traceback": [ + "\u001b[0;31m---------------------------------------------------------------------------\u001b[0m", + "\u001b[0;31mFileNotFoundError\u001b[0m Traceback (most recent call last)", + "Cell \u001b[0;32mIn[16], line 2\u001b[0m\n\u001b[1;32m 1\u001b[0m resources \u001b[38;5;241m=\u001b[39m Resources()\n\u001b[0;32m----> 2\u001b[0m \u001b[43mresources\u001b[49m\u001b[38;5;241;43m.\u001b[39;49m\u001b[43mimport_signor_tsv\u001b[49m\u001b[43m(\u001b[49m\u001b[38;5;124;43m\"\u001b[39;49m\u001b[38;5;124;43m./all_data_18_03_24.tsv\u001b[39;49m\u001b[38;5;124;43m\"\u001b[39;49m\u001b[43m)\u001b[49m \u001b[38;5;66;03m# this function accept only tab separated values\u001b[39;00m\n", + "File \u001b[0;32m~/anaconda3/envs/omniflow_env/lib/python3.10/site-packages/omniflow_project/_inputs/resources.py:79\u001b[0m, in \u001b[0;36mResources.import_signor_tsv\u001b[0;34m(self, signor_file)\u001b[0m\n\u001b[1;32m 78\u001b[0m \u001b[38;5;28;01mdef\u001b[39;00m \u001b[38;5;21mimport_signor_tsv\u001b[39m(\u001b[38;5;28mself\u001b[39m, signor_file):\n\u001b[0;32m---> 79\u001b[0m df_signor \u001b[38;5;241m=\u001b[39m \u001b[43mpd\u001b[49m\u001b[38;5;241;43m.\u001b[39;49m\u001b[43mread_table\u001b[49m\u001b[43m(\u001b[49m\u001b[43msignor_file\u001b[49m\u001b[43m)\u001b[49m\n\u001b[1;32m 80\u001b[0m \u001b[38;5;66;03m# Substitute \"up-regulates\" with \"stimulation\" and \"down-regulates\" with \"inhibition\" in the EFFECT column\u001b[39;00m\n\u001b[1;32m 81\u001b[0m \n\u001b[1;32m 82\u001b[0m \u001b[38;5;66;03m# Function to determine if the effect is stimulation\u001b[39;00m\n\u001b[1;32m 83\u001b[0m \u001b[38;5;28;01mdef\u001b[39;00m \u001b[38;5;21mis_stimulation\u001b[39m(effect):\n", + "File \u001b[0;32m~/anaconda3/envs/omniflow_env/lib/python3.10/site-packages/pandas/util/_decorators.py:311\u001b[0m, in \u001b[0;36mdeprecate_nonkeyword_arguments..decorate..wrapper\u001b[0;34m(*args, **kwargs)\u001b[0m\n\u001b[1;32m 305\u001b[0m \u001b[38;5;28;01mif\u001b[39;00m \u001b[38;5;28mlen\u001b[39m(args) \u001b[38;5;241m>\u001b[39m num_allow_args:\n\u001b[1;32m 306\u001b[0m warnings\u001b[38;5;241m.\u001b[39mwarn(\n\u001b[1;32m 307\u001b[0m msg\u001b[38;5;241m.\u001b[39mformat(arguments\u001b[38;5;241m=\u001b[39marguments),\n\u001b[1;32m 308\u001b[0m \u001b[38;5;167;01mFutureWarning\u001b[39;00m,\n\u001b[1;32m 309\u001b[0m stacklevel\u001b[38;5;241m=\u001b[39mstacklevel,\n\u001b[1;32m 310\u001b[0m )\n\u001b[0;32m--> 311\u001b[0m \u001b[38;5;28;01mreturn\u001b[39;00m \u001b[43mfunc\u001b[49m\u001b[43m(\u001b[49m\u001b[38;5;241;43m*\u001b[39;49m\u001b[43margs\u001b[49m\u001b[43m,\u001b[49m\u001b[43m \u001b[49m\u001b[38;5;241;43m*\u001b[39;49m\u001b[38;5;241;43m*\u001b[39;49m\u001b[43mkwargs\u001b[49m\u001b[43m)\u001b[49m\n", + "File \u001b[0;32m~/anaconda3/envs/omniflow_env/lib/python3.10/site-packages/pandas/io/parsers/readers.py:683\u001b[0m, in \u001b[0;36mread_table\u001b[0;34m(filepath_or_buffer, sep, delimiter, header, names, index_col, usecols, squeeze, prefix, mangle_dupe_cols, dtype, engine, converters, true_values, false_values, skipinitialspace, skiprows, skipfooter, nrows, na_values, keep_default_na, na_filter, verbose, skip_blank_lines, parse_dates, infer_datetime_format, keep_date_col, date_parser, dayfirst, cache_dates, iterator, chunksize, compression, thousands, decimal, lineterminator, quotechar, quoting, doublequote, escapechar, comment, encoding, dialect, error_bad_lines, warn_bad_lines, on_bad_lines, encoding_errors, delim_whitespace, low_memory, memory_map, float_precision)\u001b[0m\n\u001b[1;32m 668\u001b[0m kwds_defaults \u001b[38;5;241m=\u001b[39m _refine_defaults_read(\n\u001b[1;32m 669\u001b[0m dialect,\n\u001b[1;32m 670\u001b[0m delimiter,\n\u001b[0;32m (...)\u001b[0m\n\u001b[1;32m 679\u001b[0m defaults\u001b[38;5;241m=\u001b[39m{\u001b[38;5;124m\"\u001b[39m\u001b[38;5;124mdelimiter\u001b[39m\u001b[38;5;124m\"\u001b[39m: \u001b[38;5;124m\"\u001b[39m\u001b[38;5;130;01m\\t\u001b[39;00m\u001b[38;5;124m\"\u001b[39m},\n\u001b[1;32m 680\u001b[0m )\n\u001b[1;32m 681\u001b[0m kwds\u001b[38;5;241m.\u001b[39mupdate(kwds_defaults)\n\u001b[0;32m--> 683\u001b[0m \u001b[38;5;28;01mreturn\u001b[39;00m \u001b[43m_read\u001b[49m\u001b[43m(\u001b[49m\u001b[43mfilepath_or_buffer\u001b[49m\u001b[43m,\u001b[49m\u001b[43m \u001b[49m\u001b[43mkwds\u001b[49m\u001b[43m)\u001b[49m\n", + "File \u001b[0;32m~/anaconda3/envs/omniflow_env/lib/python3.10/site-packages/pandas/io/parsers/readers.py:482\u001b[0m, in \u001b[0;36m_read\u001b[0;34m(filepath_or_buffer, kwds)\u001b[0m\n\u001b[1;32m 479\u001b[0m _validate_names(kwds\u001b[38;5;241m.\u001b[39mget(\u001b[38;5;124m\"\u001b[39m\u001b[38;5;124mnames\u001b[39m\u001b[38;5;124m\"\u001b[39m, \u001b[38;5;28;01mNone\u001b[39;00m))\n\u001b[1;32m 481\u001b[0m \u001b[38;5;66;03m# Create the parser.\u001b[39;00m\n\u001b[0;32m--> 482\u001b[0m parser \u001b[38;5;241m=\u001b[39m \u001b[43mTextFileReader\u001b[49m\u001b[43m(\u001b[49m\u001b[43mfilepath_or_buffer\u001b[49m\u001b[43m,\u001b[49m\u001b[43m \u001b[49m\u001b[38;5;241;43m*\u001b[39;49m\u001b[38;5;241;43m*\u001b[39;49m\u001b[43mkwds\u001b[49m\u001b[43m)\u001b[49m\n\u001b[1;32m 484\u001b[0m \u001b[38;5;28;01mif\u001b[39;00m chunksize \u001b[38;5;129;01mor\u001b[39;00m iterator:\n\u001b[1;32m 485\u001b[0m \u001b[38;5;28;01mreturn\u001b[39;00m parser\n", + "File \u001b[0;32m~/anaconda3/envs/omniflow_env/lib/python3.10/site-packages/pandas/io/parsers/readers.py:811\u001b[0m, in \u001b[0;36mTextFileReader.__init__\u001b[0;34m(self, f, engine, **kwds)\u001b[0m\n\u001b[1;32m 808\u001b[0m \u001b[38;5;28;01mif\u001b[39;00m \u001b[38;5;124m\"\u001b[39m\u001b[38;5;124mhas_index_names\u001b[39m\u001b[38;5;124m\"\u001b[39m \u001b[38;5;129;01min\u001b[39;00m kwds:\n\u001b[1;32m 809\u001b[0m \u001b[38;5;28mself\u001b[39m\u001b[38;5;241m.\u001b[39moptions[\u001b[38;5;124m\"\u001b[39m\u001b[38;5;124mhas_index_names\u001b[39m\u001b[38;5;124m\"\u001b[39m] \u001b[38;5;241m=\u001b[39m kwds[\u001b[38;5;124m\"\u001b[39m\u001b[38;5;124mhas_index_names\u001b[39m\u001b[38;5;124m\"\u001b[39m]\n\u001b[0;32m--> 811\u001b[0m \u001b[38;5;28mself\u001b[39m\u001b[38;5;241m.\u001b[39m_engine \u001b[38;5;241m=\u001b[39m \u001b[38;5;28;43mself\u001b[39;49m\u001b[38;5;241;43m.\u001b[39;49m\u001b[43m_make_engine\u001b[49m\u001b[43m(\u001b[49m\u001b[38;5;28;43mself\u001b[39;49m\u001b[38;5;241;43m.\u001b[39;49m\u001b[43mengine\u001b[49m\u001b[43m)\u001b[49m\n", + "File \u001b[0;32m~/anaconda3/envs/omniflow_env/lib/python3.10/site-packages/pandas/io/parsers/readers.py:1040\u001b[0m, in \u001b[0;36mTextFileReader._make_engine\u001b[0;34m(self, engine)\u001b[0m\n\u001b[1;32m 1036\u001b[0m \u001b[38;5;28;01mraise\u001b[39;00m \u001b[38;5;167;01mValueError\u001b[39;00m(\n\u001b[1;32m 1037\u001b[0m \u001b[38;5;124mf\u001b[39m\u001b[38;5;124m\"\u001b[39m\u001b[38;5;124mUnknown engine: \u001b[39m\u001b[38;5;132;01m{\u001b[39;00mengine\u001b[38;5;132;01m}\u001b[39;00m\u001b[38;5;124m (valid options are \u001b[39m\u001b[38;5;132;01m{\u001b[39;00mmapping\u001b[38;5;241m.\u001b[39mkeys()\u001b[38;5;132;01m}\u001b[39;00m\u001b[38;5;124m)\u001b[39m\u001b[38;5;124m\"\u001b[39m\n\u001b[1;32m 1038\u001b[0m )\n\u001b[1;32m 1039\u001b[0m \u001b[38;5;66;03m# error: Too many arguments for \"ParserBase\"\u001b[39;00m\n\u001b[0;32m-> 1040\u001b[0m \u001b[38;5;28;01mreturn\u001b[39;00m \u001b[43mmapping\u001b[49m\u001b[43m[\u001b[49m\u001b[43mengine\u001b[49m\u001b[43m]\u001b[49m\u001b[43m(\u001b[49m\u001b[38;5;28;43mself\u001b[39;49m\u001b[38;5;241;43m.\u001b[39;49m\u001b[43mf\u001b[49m\u001b[43m,\u001b[49m\u001b[43m \u001b[49m\u001b[38;5;241;43m*\u001b[39;49m\u001b[38;5;241;43m*\u001b[39;49m\u001b[38;5;28;43mself\u001b[39;49m\u001b[38;5;241;43m.\u001b[39;49m\u001b[43moptions\u001b[49m\u001b[43m)\u001b[49m\n", + "File \u001b[0;32m~/anaconda3/envs/omniflow_env/lib/python3.10/site-packages/pandas/io/parsers/c_parser_wrapper.py:51\u001b[0m, in \u001b[0;36mCParserWrapper.__init__\u001b[0;34m(self, src, **kwds)\u001b[0m\n\u001b[1;32m 48\u001b[0m kwds[\u001b[38;5;124m\"\u001b[39m\u001b[38;5;124musecols\u001b[39m\u001b[38;5;124m\"\u001b[39m] \u001b[38;5;241m=\u001b[39m \u001b[38;5;28mself\u001b[39m\u001b[38;5;241m.\u001b[39musecols\n\u001b[1;32m 50\u001b[0m \u001b[38;5;66;03m# open handles\u001b[39;00m\n\u001b[0;32m---> 51\u001b[0m \u001b[38;5;28;43mself\u001b[39;49m\u001b[38;5;241;43m.\u001b[39;49m\u001b[43m_open_handles\u001b[49m\u001b[43m(\u001b[49m\u001b[43msrc\u001b[49m\u001b[43m,\u001b[49m\u001b[43m \u001b[49m\u001b[43mkwds\u001b[49m\u001b[43m)\u001b[49m\n\u001b[1;32m 52\u001b[0m \u001b[38;5;28;01massert\u001b[39;00m \u001b[38;5;28mself\u001b[39m\u001b[38;5;241m.\u001b[39mhandles \u001b[38;5;129;01mis\u001b[39;00m \u001b[38;5;129;01mnot\u001b[39;00m \u001b[38;5;28;01mNone\u001b[39;00m\n\u001b[1;32m 54\u001b[0m \u001b[38;5;66;03m# Have to pass int, would break tests using TextReader directly otherwise :(\u001b[39;00m\n", + "File \u001b[0;32m~/anaconda3/envs/omniflow_env/lib/python3.10/site-packages/pandas/io/parsers/base_parser.py:222\u001b[0m, in \u001b[0;36mParserBase._open_handles\u001b[0;34m(self, src, kwds)\u001b[0m\n\u001b[1;32m 218\u001b[0m \u001b[38;5;28;01mdef\u001b[39;00m \u001b[38;5;21m_open_handles\u001b[39m(\u001b[38;5;28mself\u001b[39m, src: FilePathOrBuffer, kwds: \u001b[38;5;28mdict\u001b[39m[\u001b[38;5;28mstr\u001b[39m, Any]) \u001b[38;5;241m-\u001b[39m\u001b[38;5;241m>\u001b[39m \u001b[38;5;28;01mNone\u001b[39;00m:\n\u001b[1;32m 219\u001b[0m \u001b[38;5;250m \u001b[39m\u001b[38;5;124;03m\"\"\"\u001b[39;00m\n\u001b[1;32m 220\u001b[0m \u001b[38;5;124;03m Let the readers open IOHandles after they are done with their potential raises.\u001b[39;00m\n\u001b[1;32m 221\u001b[0m \u001b[38;5;124;03m \"\"\"\u001b[39;00m\n\u001b[0;32m--> 222\u001b[0m \u001b[38;5;28mself\u001b[39m\u001b[38;5;241m.\u001b[39mhandles \u001b[38;5;241m=\u001b[39m \u001b[43mget_handle\u001b[49m\u001b[43m(\u001b[49m\n\u001b[1;32m 223\u001b[0m \u001b[43m \u001b[49m\u001b[43msrc\u001b[49m\u001b[43m,\u001b[49m\n\u001b[1;32m 224\u001b[0m \u001b[43m \u001b[49m\u001b[38;5;124;43m\"\u001b[39;49m\u001b[38;5;124;43mr\u001b[39;49m\u001b[38;5;124;43m\"\u001b[39;49m\u001b[43m,\u001b[49m\n\u001b[1;32m 225\u001b[0m \u001b[43m \u001b[49m\u001b[43mencoding\u001b[49m\u001b[38;5;241;43m=\u001b[39;49m\u001b[43mkwds\u001b[49m\u001b[38;5;241;43m.\u001b[39;49m\u001b[43mget\u001b[49m\u001b[43m(\u001b[49m\u001b[38;5;124;43m\"\u001b[39;49m\u001b[38;5;124;43mencoding\u001b[39;49m\u001b[38;5;124;43m\"\u001b[39;49m\u001b[43m,\u001b[49m\u001b[43m \u001b[49m\u001b[38;5;28;43;01mNone\u001b[39;49;00m\u001b[43m)\u001b[49m\u001b[43m,\u001b[49m\n\u001b[1;32m 226\u001b[0m \u001b[43m \u001b[49m\u001b[43mcompression\u001b[49m\u001b[38;5;241;43m=\u001b[39;49m\u001b[43mkwds\u001b[49m\u001b[38;5;241;43m.\u001b[39;49m\u001b[43mget\u001b[49m\u001b[43m(\u001b[49m\u001b[38;5;124;43m\"\u001b[39;49m\u001b[38;5;124;43mcompression\u001b[39;49m\u001b[38;5;124;43m\"\u001b[39;49m\u001b[43m,\u001b[49m\u001b[43m \u001b[49m\u001b[38;5;28;43;01mNone\u001b[39;49;00m\u001b[43m)\u001b[49m\u001b[43m,\u001b[49m\n\u001b[1;32m 227\u001b[0m \u001b[43m \u001b[49m\u001b[43mmemory_map\u001b[49m\u001b[38;5;241;43m=\u001b[39;49m\u001b[43mkwds\u001b[49m\u001b[38;5;241;43m.\u001b[39;49m\u001b[43mget\u001b[49m\u001b[43m(\u001b[49m\u001b[38;5;124;43m\"\u001b[39;49m\u001b[38;5;124;43mmemory_map\u001b[39;49m\u001b[38;5;124;43m\"\u001b[39;49m\u001b[43m,\u001b[49m\u001b[43m \u001b[49m\u001b[38;5;28;43;01mFalse\u001b[39;49;00m\u001b[43m)\u001b[49m\u001b[43m,\u001b[49m\n\u001b[1;32m 228\u001b[0m \u001b[43m \u001b[49m\u001b[43mstorage_options\u001b[49m\u001b[38;5;241;43m=\u001b[39;49m\u001b[43mkwds\u001b[49m\u001b[38;5;241;43m.\u001b[39;49m\u001b[43mget\u001b[49m\u001b[43m(\u001b[49m\u001b[38;5;124;43m\"\u001b[39;49m\u001b[38;5;124;43mstorage_options\u001b[39;49m\u001b[38;5;124;43m\"\u001b[39;49m\u001b[43m,\u001b[49m\u001b[43m \u001b[49m\u001b[38;5;28;43;01mNone\u001b[39;49;00m\u001b[43m)\u001b[49m\u001b[43m,\u001b[49m\n\u001b[1;32m 229\u001b[0m \u001b[43m \u001b[49m\u001b[43merrors\u001b[49m\u001b[38;5;241;43m=\u001b[39;49m\u001b[43mkwds\u001b[49m\u001b[38;5;241;43m.\u001b[39;49m\u001b[43mget\u001b[49m\u001b[43m(\u001b[49m\u001b[38;5;124;43m\"\u001b[39;49m\u001b[38;5;124;43mencoding_errors\u001b[39;49m\u001b[38;5;124;43m\"\u001b[39;49m\u001b[43m,\u001b[49m\u001b[43m \u001b[49m\u001b[38;5;124;43m\"\u001b[39;49m\u001b[38;5;124;43mstrict\u001b[39;49m\u001b[38;5;124;43m\"\u001b[39;49m\u001b[43m)\u001b[49m\u001b[43m,\u001b[49m\n\u001b[1;32m 230\u001b[0m \u001b[43m \u001b[49m\u001b[43m)\u001b[49m\n", + "File \u001b[0;32m~/anaconda3/envs/omniflow_env/lib/python3.10/site-packages/pandas/io/common.py:702\u001b[0m, in \u001b[0;36mget_handle\u001b[0;34m(path_or_buf, mode, encoding, compression, memory_map, is_text, errors, storage_options)\u001b[0m\n\u001b[1;32m 697\u001b[0m \u001b[38;5;28;01melif\u001b[39;00m \u001b[38;5;28misinstance\u001b[39m(handle, \u001b[38;5;28mstr\u001b[39m):\n\u001b[1;32m 698\u001b[0m \u001b[38;5;66;03m# Check whether the filename is to be opened in binary mode.\u001b[39;00m\n\u001b[1;32m 699\u001b[0m \u001b[38;5;66;03m# Binary mode does not support 'encoding' and 'newline'.\u001b[39;00m\n\u001b[1;32m 700\u001b[0m \u001b[38;5;28;01mif\u001b[39;00m ioargs\u001b[38;5;241m.\u001b[39mencoding \u001b[38;5;129;01mand\u001b[39;00m \u001b[38;5;124m\"\u001b[39m\u001b[38;5;124mb\u001b[39m\u001b[38;5;124m\"\u001b[39m \u001b[38;5;129;01mnot\u001b[39;00m \u001b[38;5;129;01min\u001b[39;00m ioargs\u001b[38;5;241m.\u001b[39mmode:\n\u001b[1;32m 701\u001b[0m \u001b[38;5;66;03m# Encoding\u001b[39;00m\n\u001b[0;32m--> 702\u001b[0m handle \u001b[38;5;241m=\u001b[39m \u001b[38;5;28;43mopen\u001b[39;49m\u001b[43m(\u001b[49m\n\u001b[1;32m 703\u001b[0m \u001b[43m \u001b[49m\u001b[43mhandle\u001b[49m\u001b[43m,\u001b[49m\n\u001b[1;32m 704\u001b[0m \u001b[43m \u001b[49m\u001b[43mioargs\u001b[49m\u001b[38;5;241;43m.\u001b[39;49m\u001b[43mmode\u001b[49m\u001b[43m,\u001b[49m\n\u001b[1;32m 705\u001b[0m \u001b[43m \u001b[49m\u001b[43mencoding\u001b[49m\u001b[38;5;241;43m=\u001b[39;49m\u001b[43mioargs\u001b[49m\u001b[38;5;241;43m.\u001b[39;49m\u001b[43mencoding\u001b[49m\u001b[43m,\u001b[49m\n\u001b[1;32m 706\u001b[0m \u001b[43m 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null, + "id": "1ee6984a-1a6e-410e-b335-9acc1359b359", + "metadata": {}, + "outputs": [], + "source": [ + "%%time\n", + "new_net1 = Network(genes, resources=resources.interactions) # here we load the signor interactions" + ] + }, + { + "cell_type": "markdown", + "id": "7aae5ca7-5696-44ba-9e75-4a2d1eb0a2d9", + "metadata": {}, + "source": [ + "### Build network\n", + "\n", + "NB! It is important to note, that not all the databases have the same structure as Omnipath. In particular, if the columns \"consensus\" are missing, we suggest to avoid to use the flag \"consensus\" or \"consensus_only\" when using Omniflow with customize databases." + ] + }, + { + "cell_type": "code", + "execution_count": null, + "id": "12052b3b-854f-41a0-a762-20de5cbc7b35", + "metadata": {}, + "outputs": [], + "source": [ + "%%time\n", + "new_net1.complete_connection(mode=\"ALL\", maxlen=6, k_mean=\"tight\", only_signed=True,\n", + " connect_node_when_first_introduced=True) # here, consensus_only is missing, in this way it is automatically False" + ] + }, + { + "cell_type": "markdown", + "id": "64b445e7-2e45-40ee-9ee9-268965b4d55b", + "metadata": {}, + "source": [ + "## SIGNOR uses has different identifiers for complexes, protein family, phenotype, etc.\n", + "## It is possible that the network contains nodes names like \"Signor_pf32\" or something like this... This is not yet translated, but if you are interested in what those nodes consist of, you can use download their vocabulary for the entities: https://signor.uniroma2.it/downloads.php\n", + "## Maybe we are going to integrate this too... " + ] + }, + { + "cell_type": "markdown", + "id": "6b54c437", + "metadata": {}, + "source": [ + "### Finally we can export the network in bnet format with some basic logical equations or in sif format for Cytoscape visualization" + ] + }, + { + "cell_type": "code", + "execution_count": null, + "id": "547e4090", + "metadata": {}, + "outputs": [], + "source": [ + "from omniflow_project._outputs.exports import Exports" + ] + }, + { + "cell_type": "code", + "execution_count": null, + "id": "6fd81835", + "metadata": {}, + "outputs": [], + "source": [ + "export = Exports(new_net1)" + ] + }, + { + "cell_type": "code", + "execution_count": null, + "id": "a408094f", + "metadata": {}, + "outputs": [], + "source": [ + "export.export_bnet()\n", + "export.export_sif()" + ] + }, + { + "cell_type": "markdown", + "id": "8ed135d3-9f71-4cec-9381-96c63fba766e", + "metadata": {}, + "source": [ + "### Gene Ontology\n", + "## A new feature of Omniflow. Now, the user can connect the nodes of the Network with markers of a certain phenotype, from Gene Ontology. " + ] + }, + { + "cell_type": "code", + "execution_count": null, + "id": "fa499a38-c22a-4a0e-b1d4-3ffb10e4a370", + "metadata": {}, + "outputs": [], + "source": [ + "%%time\n", + "new_net1.connect_genes_to_phenotype(id_accession=\"GO:0097194\", phenotype=\"execution phase of apoptosis\", only_signed=True, compress=True, maxlen=1)" + ] + }, + { + "cell_type": "markdown", + "id": "48bf53a4", + "metadata": {}, + "source": [ + "# TO DO:\n", + "\n", + "- method to print sif file with reference for each interaction (easy task)\n", + "- more utility functions (???)\n", + "- create function to look for common upstream for group of nodes" + ] + }, + { + "cell_type": "code", + "execution_count": null, + "id": "33300268-bcf6-442b-97be-c7718922a939", + "metadata": {}, + "outputs": [], + "source": [] + } + ], + "metadata": { + "kernelspec": { + "display_name": "Python 3 (ipykernel)", + "language": "python", + "name": "python3" + }, + "language_info": { + "codemirror_mode": { + "name": "ipython", + "version": 3 + }, + "file_extension": ".py", + "mimetype": "text/x-python", + "name": "python", + "nbconvert_exporter": "python", + "pygments_lexer": "ipython3", + "version": "3.10.13" + } + }, + "nbformat": 4, + "nbformat_minor": 5 +} From 9958c22d6f227f84ee370988df0009658e588102 Mon Sep 17 00:00:00 2001 From: Eirinits Date: Thu, 4 Apr 2024 11:51:13 +0200 Subject: [PATCH 06/10] Tutorial: Build phosphosite network --- notebooks/build_phosphosite_network.ipynb | 24222 ++++++++++++++++++++ 1 file changed, 24222 insertions(+) create mode 100644 notebooks/build_phosphosite_network.ipynb diff --git a/notebooks/build_phosphosite_network.ipynb b/notebooks/build_phosphosite_network.ipynb new file mode 100644 index 0000000..091f4ab --- /dev/null +++ b/notebooks/build_phosphosite_network.ipynb @@ -0,0 +1,24222 @@ +{ + "cells": [ + { + "cell_type": "markdown", + "id": "4feb78a3-acc2-455c-b206-c37b7ea47932", + "metadata": {}, + "source": [ + "## Build phosphoste network\n", + "\n", + "This notebook provides the code to create a network based on kinase-substrate interactions and the annotated effect of phosphorylation (based on PhosphositePlus) on the activity of the substrate." + ] + }, + { + "cell_type": "code", + "execution_count": 1, + "id": "3c317de8", + "metadata": {}, + "outputs": [ + { + "name": "stderr", + "output_type": "stream", + "text": [ + "/home/eirini/anaconda3/envs/omniflow_env/lib/python3.10/site-packages/tqdm/auto.py:21: TqdmWarning: IProgress not found. Please update jupyter and ipywidgets. See https://ipywidgets.readthedocs.io/en/stable/user_install.html\n", + " from .autonotebook import tqdm as notebook_tqdm\n" + ] + }, + { + "name": "stdout", + "output_type": "stream", + "text": [ + "CPU times: user 1.71 s, sys: 389 ms, total: 2.09 s\n", + "Wall time: 2.1 s\n" + ] + } + ], + "source": [ + "%%time\n", + "from omniflow_project.core.network import Network\n", + "from omniflow_project._visual.visualize_network import NetworkVisualizer\n", + "from omniflow_project._inputs.resources import Resources\n", + "from omniflow_project._annotations.gene_ontology import Ontology\n", + "import omnipath as op\n", + "import pandas as pd" + ] + }, + { + "cell_type": "markdown", + "id": "e41d36f1-b603-4d04-bea5-972c03764c92", + "metadata": {}, + "source": [ + "## 1. Specify kinase-substrate interaction file and phosphosite effect annotation\n", + "\n", + "In this example, both files we utilize are from PhosphositePlus." + ] + }, + { + "cell_type": "code", + "execution_count": 2, + "id": "17d662bc-dc7f-4597-9a42-d9da7bdd1ed3", + "metadata": {}, + "outputs": [], + "source": [ + "kinase_int_file = (\"/home/eirini/Documents/Git/omniflow_project/Kinase_Substrate_Dataset\")\n", + "phospho_effect_file = (\"/home/eirini/Documents/Git/omniflow_project/Regulatory_sites\")" + ] + }, + { + "cell_type": "markdown", + "id": "d0fd3a1c-8419-4aa7-a7bd-30f92df14c69", + "metadata": {}, + "source": [ + "## 2. Add interactions as a resource database\n", + "\n", + "The *_process_psp_interactions_* function parses the provided files to create an interaction database in the Omnipath format." + ] + }, + { + "cell_type": "code", + "execution_count": 22, + "id": "4d4cfe2f-fe7c-4764-9100-9543ac1a9a1b", + "metadata": {}, + "outputs": [ + { + "name": "stderr", + "output_type": "stream", + "text": [ + "/home/eirini/anaconda3/envs/omniflow_env/lib/python3.10/site-packages/omniflow_project/_inputs/resources.py:128: SettingWithCopyWarning: \n", + "A value is trying to be set on a copy of a slice from a DataFrame.\n", + "Try using .loc[row_indexer,col_indexer] = value instead\n", + "\n", + "See the caveats in the documentation: https://pandas.pydata.org/pandas-docs/stable/user_guide/indexing.html#returning-a-view-versus-a-copy\n", + " kinase_int_filtered['target'] = kinase_int_filtered['SUB_GENE'] + '_' + kinase_int_filtered['SUB_MOD_RSD']\n", + "/home/eirini/anaconda3/envs/omniflow_env/lib/python3.10/site-packages/omniflow_project/_inputs/resources.py:144: SettingWithCopyWarning: \n", + "A value is trying to be set on a copy of a slice from a DataFrame.\n", + "Try using .loc[row_indexer,col_indexer] = value instead\n", + "\n", + "See the caveats in the documentation: https://pandas.pydata.org/pandas-docs/stable/user_guide/indexing.html#returning-a-view-versus-a-copy\n", + " phospho_effect_filtered['MOD_RSD'] = phospho_effect_filtered['MOD_RSD'].apply(lambda x: x[:-2] if x.endswith('-p') else x)\n", + "/home/eirini/anaconda3/envs/omniflow_env/lib/python3.10/site-packages/omniflow_project/_inputs/resources.py:147: SettingWithCopyWarning: \n", + "A value is trying to be set on a copy of a slice from a DataFrame.\n", + "Try using .loc[row_indexer,col_indexer] = value instead\n", + "\n", + "See the caveats in the documentation: https://pandas.pydata.org/pandas-docs/stable/user_guide/indexing.html#returning-a-view-versus-a-copy\n", + " phospho_effect_filtered['Prot_site'] = phospho_effect_filtered['GENE'] + '_' + phospho_effect_filtered['MOD_RSD']\n", + "WARNING:root:The incoming database is missing some required columns: {'references', 'curation_effort', 'sources', 'form_complex'}\n", + "WARNING:root:This might lead to issues in running the package.\n", + "WARNING:root:The incoming database is missing some required columns: {'references', 'curation_effort', 'sources', 'form_complex'}\n", + "WARNING:root:This might lead to issues in running the package.\n" + ] + } + ], + "source": [ + "resources = Resources()\n", + "interactions = resources.process_psp_interactions(kinase_int_file, phospho_effect_file, \"human\", expand=False)\n", + "resources.add_database(interactions)" + ] + }, + { + "cell_type": "code", + "execution_count": 24, + "id": "9bc52933-3fb6-4b91-af67-454cc5891e98", + "metadata": {}, + "outputs": [ + { + "data": { + "text/html": [ + "
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...........................
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" + ], + "text/plain": [ + " source target is_directed consensus_direction \\\n", + "0 EIF2AK1 EIF2S1_S52 True False \n", + "2 PRKCD HDAC5_S259 True False \n", + "3 PRKCD PTPRA_S204 True False \n", + "4 PRKCD BCL2_S70 True False \n", + "6 PRKCD SLC9A1_S648 True False \n", + "... ... ... ... ... \n", + "14483 NUAK1 CASP6_S257 True False \n", + "14484 NUAK1 TP53_S392 True False \n", + "14489 NUAK1 TP53_S15 True False \n", + "14491 ULK2 STING1_S366 True False \n", + "14492 ULK2 BECN1_S30 True False \n", + "\n", + " consensus_stimulation consensus_inhibition is_stimulation \\\n", + "0 False False 1 \n", + "2 False False 1 \n", + "3 False False 1 \n", + "4 False False 0 \n", + "6 False False 0 \n", + "... ... ... ... \n", + "14483 False False 0 \n", + "14484 False False 1 \n", + "14489 False False 1 \n", + "14491 False False 1 \n", + "14492 False False 1 \n", + "\n", + " is_inhibition \n", + "0 1 \n", + "2 1 \n", + "3 0 \n", + "4 1 \n", + "6 1 \n", + "... ... \n", + "14483 1 \n", + "14484 0 \n", + "14489 1 \n", + "14491 0 \n", + "14492 0 \n", + "\n", + "[4758 rows x 8 columns]" + ] + }, + "execution_count": 24, + "metadata": {}, + "output_type": "execute_result" + } + ], + "source": [ + "#inspect database\n", + "interactions" + ] + }, + { + "cell_type": "markdown", + "id": "7fe1b7d5", + "metadata": {}, + "source": [ + "### 3. Define a set of phosphosites we are interested in" + ] + }, + { + "cell_type": "code", + "execution_count": 16, + "id": "a3fea926-81f1-4826-b91c-3b04124de715", + "metadata": {}, + "outputs": [], + "source": [ + "genes = ['SMAD3_S423', 'SMAD3_S425', 'TP53_S15', 'AKT1S1_T246', 'GSK3B_S9', 'GSK3B_S21', 'AKT1_S473', 'HSPB1_S78', 'HSPB1_S82', 'MAPK14_T180', 'MAPK14_Y182', 'MAP2K1_S218', 'MAP2K1_S222', 'RPS6KA1_S380', 'CREB1_S133', 'NFKBIA_S32', 'NFKBIA_S36', 'MTOR_S2448', 'JUN_S63', 'EGFR_Y1068', 'MAPK3_T202', 'MAPK3_Y204', 'PTPN11_Y542', 'STAT3_Y705', 'CHEK2_T68', 'RELA_S536', 'MARCKS_S170']\n", + "genes = ['SMAD3_S423', 'SMAD3_S425', 'TP53_S15', 'AKT1S1_T246', 'GSK3B_S9', 'GSK3B_S21', 'AKT1_S473', 'HSPB1_S78', 'HSPB1_S82', 'MAPK14_T180', 'MAPK14_Y182', 'MAP2K1_S218', 'MAP2K1_S222', 'RPS6KA1_S380', 'CREB1_S133', 'NFKBIA_S32', 'NFKBIA_S36', 'MTOR_S2448', 'JUN_S63', 'EGFR_Y1068', 'MAPK3_T202', 'MAPK3_Y204', 'PTPN11_Y542', 'STAT3_Y705', 'CHEK2_T68', 'RELA_S536', 'MARCKS_S170','SMAD3', 'TP53', 'AKT1S1', 'GSK3B', 'AKT1', 'HSPB1', 'MAPK14', 'MAP2K1', 'RPS6KA1', 'CREB1', 'NFKBIA', 'MTOR', 'JUN', 'EGFR', 'MAPK3', 'PTPN11', 'STAT3', 'CHEK2', 'RELA', 'MARCKS']\n", + "\n", + "#genes = ['SMAD3_S423', 'SMAD3_S425', 'TP53_S15', 'AKT1S1_T246', 'GSK3B_S9', 'GSK3B_S21', 'AKT1_S473', 'HSPB1_S78']" + ] + }, + { + "cell_type": "markdown", + "id": "59d3c824-ad97-43ae-9bf4-6657e7bcf72f", + "metadata": {}, + "source": [ + "### 4. Build network" + ] + }, + { + "cell_type": "code", + "execution_count": 17, + "id": "9c824c50", + "metadata": {}, + "outputs": [ + { + "name": "stdout", + "output_type": "stream", + "text": [ + "CPU times: user 113 ms, sys: 4.04 ms, total: 117 ms\n", + "Wall time: 113 ms\n" + ] + } + ], + "source": [ + "%%time\n", + "new_net1 = Network(genes, resources=resources.interactions)" + ] + }, + { + "cell_type": "code", + "execution_count": 18, + "id": "1344303a-7f14-4665-8b99-e70485b6a411", + "metadata": {}, + "outputs": [ + { + "name": "stdout", + "output_type": "stream", + "text": [ + "CPU times: user 5.14 s, sys: 4.22 ms, total: 5.14 s\n", + "Wall time: 5.14 s\n" + ] + } + ], + "source": [ + "%%time\n", + "new_net1.connect_nodes(only_signed=True)" + ] + }, + { + "cell_type": "code", + "execution_count": 19, + "id": "9a07d77b", + "metadata": {}, + "outputs": [ + { + "name": "stdout", + "output_type": "stream", + "text": [ + "looking for paths in the network with length: 0 for node SMAD3_S423 and SMAD3_S425\n", + "looking for paths in the network with length: 1 for node SMAD3_S423 and SMAD3_S425\n", + "looking for paths in the network with length: 2 for node SMAD3_S423 and SMAD3_S425\n", + "looking for paths in the network with length: 3 for node SMAD3_S423 and SMAD3_S425\n", + "looking for paths in the network with length: 4 for node SMAD3_S423 and SMAD3_S425\n", + "looking for paths in the network with length: 5 for node SMAD3_S423 and SMAD3_S425\n", + "looking for paths in the network with length: 6 for node SMAD3_S423 and SMAD3_S425\n", + "looking for paths in the network with length: 7 for node SMAD3_S423 and SMAD3_S425\n", + "looking for paths in the network with length: 8 for node SMAD3_S423 and SMAD3_S425\n", + "looking for paths in the network with length: 9 for node SMAD3_S423 and SMAD3_S425\n", + "looking for paths in the network with length: 10 for node SMAD3_S423 and SMAD3_S425\n", + "i_search = 4\n", + "Looking for paths with length: 0 for node SMAD3_S423 and SMAD3_S425\n", + "i_search = 4\n", + "Looking for paths with length: 1 for node SMAD3_S423 and SMAD3_S425\n", + "i_search = 4\n", + "Looking for paths with length: 2 for node SMAD3_S423 and SMAD3_S425\n", + "i_search = 4\n", + "Looking for paths with length: 3 for node SMAD3_S423 and SMAD3_S425\n", + "i_search = 4\n", + "Looking for paths with length: 4 for node SMAD3_S423 and SMAD3_S425\n", + "looking for paths in the network with length: 0 for node SMAD3_S423 and TP53_S15\n", + "looking for paths in the network with length: 1 for node SMAD3_S423 and TP53_S15\n", + "looking for paths in the network with length: 2 for node SMAD3_S423 and TP53_S15\n", + "looking for paths in the network with length: 3 for node SMAD3_S423 and TP53_S15\n", + "looking for paths in the network with length: 4 for node SMAD3_S423 and TP53_S15\n", + "looking for paths in the network with length: 5 for node SMAD3_S423 and TP53_S15\n", + "looking for paths in the network with length: 6 for node SMAD3_S423 and TP53_S15\n", + "looking for paths in the network with length: 7 for node SMAD3_S423 and TP53_S15\n", + "looking for paths in the network with length: 8 for node SMAD3_S423 and TP53_S15\n", + "looking for paths in the network with length: 9 for node SMAD3_S423 and TP53_S15\n", + "looking for paths in the network with length: 10 for node SMAD3_S423 and TP53_S15\n", + "i_search = 4\n", + "Looking for paths with length: 0 for node SMAD3_S423 and TP53_S15\n", + "i_search = 4\n", + "Looking for paths with length: 1 for node SMAD3_S423 and TP53_S15\n", + "i_search = 4\n", + "Looking for paths with length: 2 for node SMAD3_S423 and TP53_S15\n", + "i_search = 4\n", + "Looking for paths with length: 3 for node SMAD3_S423 and TP53_S15\n", + "i_search = 4\n", + "Looking for paths with length: 4 for node SMAD3_S423 and TP53_S15\n", + "looking for paths in the network with length: 0 for node SMAD3_S423 and AKT1S1_T246\n", + "looking for paths in the network with length: 1 for node SMAD3_S423 and AKT1S1_T246\n", + "looking for paths in the network with length: 2 for node SMAD3_S423 and AKT1S1_T246\n", + "looking for paths in the network with length: 3 for node SMAD3_S423 and AKT1S1_T246\n", + "looking for paths in the network with length: 4 for node SMAD3_S423 and AKT1S1_T246\n", + "looking for paths in the network with length: 5 for node SMAD3_S423 and AKT1S1_T246\n", + "looking for paths in the network with length: 6 for node SMAD3_S423 and AKT1S1_T246\n", + "looking for paths in the network with length: 7 for node SMAD3_S423 and AKT1S1_T246\n", + "looking for paths in the network with length: 8 for node SMAD3_S423 and AKT1S1_T246\n", + "looking for paths in the network with length: 9 for node SMAD3_S423 and AKT1S1_T246\n", + "looking for paths in the network with length: 10 for node SMAD3_S423 and AKT1S1_T246\n", + "i_search = 4\n", + "Looking for paths with length: 0 for node SMAD3_S423 and AKT1S1_T246\n", + "i_search = 4\n", + "Looking for paths with length: 1 for node SMAD3_S423 and AKT1S1_T246\n", + "i_search = 4\n", + "Looking for paths with length: 2 for node SMAD3_S423 and AKT1S1_T246\n", + "i_search = 4\n", + "Looking for paths with length: 3 for node SMAD3_S423 and AKT1S1_T246\n", + "i_search = 4\n", + "Looking for paths with length: 4 for node SMAD3_S423 and AKT1S1_T246\n", + "looking for paths in the network with length: 0 for node SMAD3_S423 and GSK3B_S9\n", + "looking for paths in the network with length: 1 for node SMAD3_S423 and GSK3B_S9\n", + "looking for paths in the network with length: 2 for node SMAD3_S423 and GSK3B_S9\n", + "looking for paths in the network with length: 3 for node SMAD3_S423 and GSK3B_S9\n", + "looking for paths in the network with length: 4 for node SMAD3_S423 and GSK3B_S9\n", + "looking for paths in the network with length: 5 for node SMAD3_S423 and GSK3B_S9\n", + "looking for paths in the network with length: 6 for node SMAD3_S423 and GSK3B_S9\n", + "looking for paths in the network with length: 7 for node SMAD3_S423 and GSK3B_S9\n", + "looking for paths in the network with length: 8 for node SMAD3_S423 and GSK3B_S9\n", + "looking for paths in the network with length: 9 for node SMAD3_S423 and GSK3B_S9\n", + "looking for paths in the network with length: 10 for node SMAD3_S423 and GSK3B_S9\n", + "i_search = 4\n", + "Looking for paths with length: 0 for node SMAD3_S423 and GSK3B_S9\n", + "i_search = 4\n", + "Looking for paths with length: 1 for node SMAD3_S423 and GSK3B_S9\n", + "i_search = 4\n", + "Looking for paths with length: 2 for node SMAD3_S423 and GSK3B_S9\n", + "i_search = 4\n", + "Looking for paths with length: 3 for node SMAD3_S423 and GSK3B_S9\n", + "i_search = 4\n", + "Looking for paths with length: 4 for node SMAD3_S423 and GSK3B_S9\n", + "looking for paths in the network with length: 0 for node SMAD3_S423 and GSK3B_S21\n", + "looking for paths in the network with length: 1 for node SMAD3_S423 and GSK3B_S21\n", + "looking for paths in the network with length: 2 for node SMAD3_S423 and GSK3B_S21\n", + "looking for paths in the network with length: 3 for node SMAD3_S423 and GSK3B_S21\n", + "looking for paths in the network with length: 4 for node SMAD3_S423 and GSK3B_S21\n", + "looking for paths in the network with length: 5 for node SMAD3_S423 and GSK3B_S21\n", + "looking for paths in the network with length: 6 for node SMAD3_S423 and GSK3B_S21\n", + "looking for paths in the network with length: 7 for node SMAD3_S423 and GSK3B_S21\n", + "looking for paths in the network with length: 8 for node SMAD3_S423 and GSK3B_S21\n", + "looking for paths in the network with length: 9 for node SMAD3_S423 and GSK3B_S21\n", + "looking for paths in the network with length: 10 for node SMAD3_S423 and GSK3B_S21\n", + "i_search = 4\n", + "Looking for paths with length: 0 for node SMAD3_S423 and GSK3B_S21\n", + "i_search = 4\n", + "Looking for paths with length: 1 for node SMAD3_S423 and GSK3B_S21\n", + "i_search = 4\n", + "Looking for paths with length: 2 for node SMAD3_S423 and GSK3B_S21\n", + "i_search = 4\n", + "Looking for paths with length: 3 for node SMAD3_S423 and GSK3B_S21\n", + "i_search = 4\n", + "Looking for paths with length: 4 for node SMAD3_S423 and GSK3B_S21\n", + "looking for paths in the network with length: 0 for node SMAD3_S423 and AKT1_S473\n", + "looking for paths in the network with length: 1 for node SMAD3_S423 and AKT1_S473\n", + "looking for paths in the network with length: 2 for node SMAD3_S423 and AKT1_S473\n", + "looking for paths in the network with length: 3 for node SMAD3_S423 and AKT1_S473\n", + "looking for paths in the network with length: 4 for node SMAD3_S423 and AKT1_S473\n", + "looking for paths in the network with length: 5 for node SMAD3_S423 and AKT1_S473\n", + "looking for paths in the network with length: 6 for node SMAD3_S423 and AKT1_S473\n", + "looking for paths in the network with length: 7 for node SMAD3_S423 and AKT1_S473\n", + "looking for paths in the network with length: 8 for node SMAD3_S423 and AKT1_S473\n", + "looking for paths in the network with length: 9 for node SMAD3_S423 and AKT1_S473\n", + "looking for paths in the network with length: 10 for node SMAD3_S423 and AKT1_S473\n", + "i_search = 4\n", + "Looking for paths with length: 0 for node SMAD3_S423 and AKT1_S473\n", + "i_search = 4\n", + "Looking for paths with length: 1 for node SMAD3_S423 and AKT1_S473\n", + "i_search = 4\n", + "Looking for paths with length: 2 for node SMAD3_S423 and AKT1_S473\n", + "i_search = 4\n", + "Looking for paths with length: 3 for node SMAD3_S423 and AKT1_S473\n", + "i_search = 4\n", + "Looking for paths with length: 4 for node SMAD3_S423 and AKT1_S473\n", + "looking for paths in the network with length: 0 for node SMAD3_S423 and HSPB1_S78\n", + "looking for paths in the network with length: 1 for node SMAD3_S423 and HSPB1_S78\n", + "looking for paths in the network with length: 2 for node SMAD3_S423 and HSPB1_S78\n", + "looking for paths in the network with length: 3 for node SMAD3_S423 and HSPB1_S78\n", + "looking for paths in the network with length: 4 for node SMAD3_S423 and HSPB1_S78\n", + "looking for paths in the network with length: 5 for node SMAD3_S423 and HSPB1_S78\n", + "looking for paths in the network with length: 6 for node SMAD3_S423 and HSPB1_S78\n", + "looking for paths in the network with length: 7 for node SMAD3_S423 and HSPB1_S78\n", + "looking for paths in the network with length: 8 for node SMAD3_S423 and HSPB1_S78\n", + "looking for paths in the network with length: 9 for node SMAD3_S423 and HSPB1_S78\n", + "looking for paths in the network with length: 10 for node SMAD3_S423 and HSPB1_S78\n", + "i_search = 4\n", + "Looking for paths with length: 0 for node SMAD3_S423 and HSPB1_S78\n", + "i_search = 4\n", + "Looking for paths with length: 1 for node SMAD3_S423 and HSPB1_S78\n", + "i_search = 4\n", + "Looking for paths with length: 2 for node SMAD3_S423 and HSPB1_S78\n", + "i_search = 4\n", + "Looking for paths with length: 3 for node SMAD3_S423 and HSPB1_S78\n", + "i_search = 4\n", + "Looking for paths with length: 4 for node SMAD3_S423 and HSPB1_S78\n", + "looking for paths in the network with length: 0 for node SMAD3_S423 and HSPB1_S82\n", + "looking for paths in the network with length: 1 for node SMAD3_S423 and HSPB1_S82\n", + "looking for paths in the network with length: 2 for node SMAD3_S423 and HSPB1_S82\n", + "looking for paths in the network with length: 3 for node SMAD3_S423 and HSPB1_S82\n", + "looking for paths in the network with length: 4 for node SMAD3_S423 and HSPB1_S82\n", + "looking for paths in the network with length: 5 for node SMAD3_S423 and HSPB1_S82\n", + "looking for paths in the network with length: 6 for node SMAD3_S423 and HSPB1_S82\n", + "looking for paths in the network with length: 7 for node SMAD3_S423 and HSPB1_S82\n", + "looking for paths in the network with length: 8 for node SMAD3_S423 and HSPB1_S82\n", + "looking for paths in the network with length: 9 for node SMAD3_S423 and HSPB1_S82\n", + "looking for paths in the network with length: 10 for node SMAD3_S423 and HSPB1_S82\n", + "i_search = 4\n", + "Looking for paths with length: 0 for node SMAD3_S423 and HSPB1_S82\n", + "i_search = 4\n", + "Looking for paths with length: 1 for node SMAD3_S423 and HSPB1_S82\n", + "i_search = 4\n", + "Looking for paths with length: 2 for node SMAD3_S423 and HSPB1_S82\n", + "i_search = 4\n", + "Looking for paths with length: 3 for node SMAD3_S423 and HSPB1_S82\n", + "i_search = 4\n", + "Looking for paths with length: 4 for node SMAD3_S423 and HSPB1_S82\n", + "looking for paths in the network with length: 0 for node SMAD3_S423 and MAPK14_T180\n", + "looking for paths in the network with length: 1 for node SMAD3_S423 and MAPK14_T180\n", + "looking for paths in the network with length: 2 for node SMAD3_S423 and MAPK14_T180\n", + "looking for paths in the network with length: 3 for node SMAD3_S423 and MAPK14_T180\n", + "looking for paths in the network with length: 4 for node SMAD3_S423 and MAPK14_T180\n", + "looking for paths in the network with length: 5 for node SMAD3_S423 and MAPK14_T180\n", + "looking for paths in the network with length: 6 for node SMAD3_S423 and MAPK14_T180\n", + "looking for paths in the network with length: 7 for node SMAD3_S423 and MAPK14_T180\n", + "looking for paths in the network with length: 8 for node SMAD3_S423 and MAPK14_T180\n", + "looking for paths in the network with length: 9 for node SMAD3_S423 and MAPK14_T180\n", + "looking for paths in the network with length: 10 for node SMAD3_S423 and MAPK14_T180\n", + "i_search = 4\n", + "Looking for paths with length: 0 for node SMAD3_S423 and MAPK14_T180\n", + "i_search = 4\n", + "Looking for paths with length: 1 for node SMAD3_S423 and MAPK14_T180\n", + "i_search = 4\n", + "Looking for paths with length: 2 for node SMAD3_S423 and MAPK14_T180\n", + "i_search = 4\n", + "Looking for paths with length: 3 for node SMAD3_S423 and MAPK14_T180\n", + "i_search = 4\n", + "Looking for paths with length: 4 for node SMAD3_S423 and MAPK14_T180\n", + "looking for paths in the network with length: 0 for node SMAD3_S423 and MAPK14_Y182\n", + "looking for paths in the network with length: 1 for node SMAD3_S423 and MAPK14_Y182\n", + "looking for paths in the network with length: 2 for node SMAD3_S423 and MAPK14_Y182\n", + "looking for paths in the network with length: 3 for node SMAD3_S423 and MAPK14_Y182\n", + "looking for paths in the network with length: 4 for node SMAD3_S423 and MAPK14_Y182\n", + "looking for paths in the network with length: 5 for node SMAD3_S423 and MAPK14_Y182\n", + "looking for paths in the network with length: 6 for node SMAD3_S423 and MAPK14_Y182\n", + "looking for paths in the network with length: 7 for node SMAD3_S423 and MAPK14_Y182\n", + "looking for paths in the network with length: 8 for node SMAD3_S423 and MAPK14_Y182\n", + "looking for paths in the network with length: 9 for node SMAD3_S423 and MAPK14_Y182\n", + "looking for paths in the network with length: 10 for node SMAD3_S423 and MAPK14_Y182\n", + "i_search = 4\n", + "Looking for paths with length: 0 for node SMAD3_S423 and MAPK14_Y182\n", + "i_search = 4\n", + "Looking for paths with length: 1 for node SMAD3_S423 and MAPK14_Y182\n", + "i_search = 4\n", + "Looking for paths with length: 2 for node SMAD3_S423 and MAPK14_Y182\n", + "i_search = 4\n", + "Looking for paths with length: 3 for node SMAD3_S423 and MAPK14_Y182\n", + "i_search = 4\n", + "Looking for paths with length: 4 for node SMAD3_S423 and MAPK14_Y182\n", + "looking for paths in the network with length: 0 for node SMAD3_S423 and MAP2K1_S218\n", + "looking for paths in the network with length: 1 for node SMAD3_S423 and MAP2K1_S218\n", + "looking for paths in the network with length: 2 for node SMAD3_S423 and MAP2K1_S218\n", + "looking for paths in the network with length: 3 for node SMAD3_S423 and MAP2K1_S218\n", + "looking for paths in the network with length: 4 for node SMAD3_S423 and MAP2K1_S218\n", + "looking for paths in the network with length: 5 for node SMAD3_S423 and MAP2K1_S218\n", + "looking for paths in the network with length: 6 for node SMAD3_S423 and MAP2K1_S218\n", + "looking for paths in the network with length: 7 for node SMAD3_S423 and MAP2K1_S218\n", + "looking for paths in the network with length: 8 for node SMAD3_S423 and MAP2K1_S218\n", + "looking for paths in the network with length: 9 for node SMAD3_S423 and MAP2K1_S218\n", + "looking for paths in the network with length: 10 for node SMAD3_S423 and MAP2K1_S218\n", + "i_search = 4\n", + "Looking for paths with length: 0 for node SMAD3_S423 and MAP2K1_S218\n", + "i_search = 4\n", + "Looking for paths with length: 1 for node SMAD3_S423 and MAP2K1_S218\n", + "i_search = 4\n", + "Looking for paths with length: 2 for node SMAD3_S423 and MAP2K1_S218\n", + "i_search = 4\n", + "Looking for paths with length: 3 for node SMAD3_S423 and MAP2K1_S218\n", + "i_search = 4\n", + "Looking for paths with length: 4 for node SMAD3_S423 and MAP2K1_S218\n", + "looking for paths in the network with length: 0 for node SMAD3_S423 and MAP2K1_S222\n", + "looking for paths in the network with length: 1 for node SMAD3_S423 and MAP2K1_S222\n", + "looking for paths in the network with length: 2 for node SMAD3_S423 and MAP2K1_S222\n", + "looking for paths in the network with length: 3 for node SMAD3_S423 and MAP2K1_S222\n", + "looking for paths in the network with length: 4 for node SMAD3_S423 and MAP2K1_S222\n", + "looking for paths in the network with length: 5 for node SMAD3_S423 and MAP2K1_S222\n", + "looking for paths in the network with length: 6 for node SMAD3_S423 and MAP2K1_S222\n", + "looking for paths in the network with length: 7 for node SMAD3_S423 and MAP2K1_S222\n", + "looking for paths in the network with length: 8 for node SMAD3_S423 and MAP2K1_S222\n", + "looking for paths in the network with length: 9 for node SMAD3_S423 and MAP2K1_S222\n", + "looking for paths in the network with length: 10 for node SMAD3_S423 and MAP2K1_S222\n", + "i_search = 4\n", + "Looking for paths with length: 0 for node SMAD3_S423 and MAP2K1_S222\n", + "i_search = 4\n", + "Looking for paths with length: 1 for node SMAD3_S423 and MAP2K1_S222\n", + "i_search = 4\n", + "Looking for paths with length: 2 for node SMAD3_S423 and MAP2K1_S222\n", + "i_search = 4\n", + "Looking for paths with length: 3 for node SMAD3_S423 and MAP2K1_S222\n", + "i_search = 4\n", + "Looking for paths with length: 4 for node SMAD3_S423 and MAP2K1_S222\n", + "looking for paths in the network with length: 0 for node SMAD3_S423 and RPS6KA1_S380\n", + "looking for paths in the network with length: 1 for node SMAD3_S423 and RPS6KA1_S380\n", + "looking for paths in the network with length: 2 for node SMAD3_S423 and RPS6KA1_S380\n", + "looking for paths in the network with length: 3 for node SMAD3_S423 and RPS6KA1_S380\n", + "looking for paths in the network with length: 4 for node SMAD3_S423 and RPS6KA1_S380\n", + "looking for paths in the network with length: 5 for node SMAD3_S423 and RPS6KA1_S380\n", + "looking for paths in the network with length: 6 for node SMAD3_S423 and RPS6KA1_S380\n", + "looking for paths in the network with length: 7 for node SMAD3_S423 and RPS6KA1_S380\n", + "looking for paths in the network with length: 8 for node SMAD3_S423 and RPS6KA1_S380\n", + "looking for paths in the network with length: 9 for node SMAD3_S423 and RPS6KA1_S380\n", + "looking for paths in the network with length: 10 for node SMAD3_S423 and RPS6KA1_S380\n", + "i_search = 4\n", + "Looking for paths with length: 0 for node SMAD3_S423 and RPS6KA1_S380\n", + "i_search = 4\n", + "Looking for paths with length: 1 for node SMAD3_S423 and RPS6KA1_S380\n", + "i_search = 4\n", + "Looking for paths with length: 2 for node SMAD3_S423 and RPS6KA1_S380\n", + "i_search = 4\n", + "Looking for paths with length: 3 for node SMAD3_S423 and RPS6KA1_S380\n", + "i_search = 4\n", + "Looking for paths with length: 4 for node SMAD3_S423 and RPS6KA1_S380\n", + "looking for paths in the network with length: 0 for node SMAD3_S423 and CREB1_S133\n", + "looking for paths in the network with length: 1 for node SMAD3_S423 and CREB1_S133\n", + "looking for paths in the network with length: 2 for node SMAD3_S423 and CREB1_S133\n", + "looking for paths in the network with length: 3 for node SMAD3_S423 and CREB1_S133\n", + "looking for paths in the network with length: 4 for node SMAD3_S423 and CREB1_S133\n", + "looking for paths in the network with length: 5 for node SMAD3_S423 and CREB1_S133\n", + "looking for paths in the network with length: 6 for node SMAD3_S423 and CREB1_S133\n", + "looking for paths in the network with length: 7 for node SMAD3_S423 and CREB1_S133\n", + "looking for paths in the network with length: 8 for node SMAD3_S423 and CREB1_S133\n", + "looking for paths in the network with length: 9 for node SMAD3_S423 and CREB1_S133\n", + "looking for paths in the network with length: 10 for node SMAD3_S423 and CREB1_S133\n", + "i_search = 4\n", + "Looking for paths with length: 0 for node SMAD3_S423 and CREB1_S133\n", + "i_search = 4\n", + "Looking for paths with length: 1 for node SMAD3_S423 and CREB1_S133\n", + "i_search = 4\n", + "Looking for paths with length: 2 for node SMAD3_S423 and CREB1_S133\n", + "i_search = 4\n", + "Looking for paths with length: 3 for node SMAD3_S423 and CREB1_S133\n", + "i_search = 4\n", + "Looking for paths with length: 4 for node SMAD3_S423 and CREB1_S133\n", + "looking for paths in the network with length: 0 for node SMAD3_S423 and NFKBIA_S32\n", + "looking for paths in the network with length: 1 for node SMAD3_S423 and NFKBIA_S32\n", + "looking for paths in the network with length: 2 for node SMAD3_S423 and NFKBIA_S32\n", + "looking for paths in the network with length: 3 for node SMAD3_S423 and NFKBIA_S32\n", + "looking for paths in the network with length: 4 for node SMAD3_S423 and NFKBIA_S32\n", + "looking for paths in the network with length: 5 for node SMAD3_S423 and NFKBIA_S32\n", + "looking for paths in the network with length: 6 for node SMAD3_S423 and NFKBIA_S32\n", + "looking for paths in the network with length: 7 for node SMAD3_S423 and NFKBIA_S32\n", + "looking for paths in the network with length: 8 for node SMAD3_S423 and NFKBIA_S32\n", + "looking for paths in the network with length: 9 for node SMAD3_S423 and NFKBIA_S32\n", + "looking for paths in the network with length: 10 for node SMAD3_S423 and NFKBIA_S32\n", + "i_search = 4\n", + "Looking for paths with length: 0 for node SMAD3_S423 and NFKBIA_S32\n", + "i_search = 4\n", + "Looking for paths with length: 1 for node SMAD3_S423 and NFKBIA_S32\n", + "i_search = 4\n", + "Looking for paths with length: 2 for node SMAD3_S423 and NFKBIA_S32\n", + "i_search = 4\n", + "Looking for paths with length: 3 for node SMAD3_S423 and NFKBIA_S32\n", + "i_search = 4\n", + "Looking for paths with length: 4 for node SMAD3_S423 and NFKBIA_S32\n", + "looking for paths in the network with length: 0 for node SMAD3_S423 and NFKBIA_S36\n", + "looking for paths in the network with length: 1 for node SMAD3_S423 and NFKBIA_S36\n", + "looking for paths in the network with length: 2 for node SMAD3_S423 and NFKBIA_S36\n", + "looking for paths in the network with length: 3 for node SMAD3_S423 and NFKBIA_S36\n", + "looking for paths in the network with length: 4 for node SMAD3_S423 and NFKBIA_S36\n", + "looking for paths in the network with length: 5 for node SMAD3_S423 and NFKBIA_S36\n", + "looking for paths in the network with length: 6 for node SMAD3_S423 and NFKBIA_S36\n", + "looking for paths in the network with length: 7 for node SMAD3_S423 and NFKBIA_S36\n", + "looking for paths in the network with length: 8 for node SMAD3_S423 and NFKBIA_S36\n", + "looking for paths in the network with length: 9 for node SMAD3_S423 and NFKBIA_S36\n", + "looking for paths in the network with length: 10 for node SMAD3_S423 and NFKBIA_S36\n", + "i_search = 4\n", + "Looking for paths with length: 0 for node SMAD3_S423 and NFKBIA_S36\n", + "i_search = 4\n", + "Looking for paths with length: 1 for node SMAD3_S423 and NFKBIA_S36\n", + "i_search = 4\n", + "Looking for paths with length: 2 for node SMAD3_S423 and NFKBIA_S36\n", + "i_search = 4\n", + "Looking for paths with length: 3 for node SMAD3_S423 and NFKBIA_S36\n", + "i_search = 4\n", + "Looking for paths with length: 4 for node SMAD3_S423 and NFKBIA_S36\n", + "looking for paths in the network with length: 0 for node SMAD3_S423 and MTOR_S2448\n", + "looking for paths in the network with length: 1 for node SMAD3_S423 and MTOR_S2448\n", + "looking for paths in the network with length: 2 for node SMAD3_S423 and MTOR_S2448\n", + "looking for paths in the network with length: 3 for node SMAD3_S423 and MTOR_S2448\n", + "looking for paths in the network with length: 4 for node SMAD3_S423 and MTOR_S2448\n", + "looking for paths in the network with length: 5 for node SMAD3_S423 and MTOR_S2448\n", + "looking for paths in the network with length: 6 for node SMAD3_S423 and MTOR_S2448\n", + "looking for paths in the network with length: 7 for node SMAD3_S423 and MTOR_S2448\n", + "looking for paths in the network with length: 8 for node SMAD3_S423 and MTOR_S2448\n", + "looking for paths in the network with length: 9 for node SMAD3_S423 and MTOR_S2448\n", + "looking for paths in the network with length: 10 for node SMAD3_S423 and MTOR_S2448\n", + "i_search = 4\n", + "Looking for paths with length: 0 for node SMAD3_S423 and MTOR_S2448\n", + "i_search = 4\n", + "Looking for paths with length: 1 for node SMAD3_S423 and MTOR_S2448\n", + "i_search = 4\n", + "Looking for paths with length: 2 for node SMAD3_S423 and MTOR_S2448\n", + "i_search = 4\n", + "Looking for paths with length: 3 for node SMAD3_S423 and MTOR_S2448\n", + "i_search = 4\n", + "Looking for paths with length: 4 for node SMAD3_S423 and MTOR_S2448\n", + "looking for paths in the network with length: 0 for node SMAD3_S423 and JUN_S63\n", + "looking for paths in the network with length: 1 for node SMAD3_S423 and JUN_S63\n", + "looking for paths in the network with length: 2 for node SMAD3_S423 and JUN_S63\n", + "looking for paths in the network with length: 3 for node SMAD3_S423 and JUN_S63\n", + "looking for paths in the network with length: 4 for node SMAD3_S423 and JUN_S63\n", + "looking for paths in the network with length: 5 for node SMAD3_S423 and JUN_S63\n", + "looking for paths in the network with length: 6 for node SMAD3_S423 and JUN_S63\n", + "looking for paths in the network with length: 7 for node SMAD3_S423 and JUN_S63\n", + "looking for paths in the network with length: 8 for node SMAD3_S423 and JUN_S63\n", + "looking for paths in the network with length: 9 for node SMAD3_S423 and JUN_S63\n", + "looking for paths in the network with length: 10 for node SMAD3_S423 and JUN_S63\n", + "i_search = 4\n", + "Looking for paths with length: 0 for node SMAD3_S423 and JUN_S63\n", + "i_search = 4\n", + "Looking for paths with length: 1 for node SMAD3_S423 and JUN_S63\n", + "i_search = 4\n", + "Looking for paths with length: 2 for node SMAD3_S423 and JUN_S63\n", + "i_search = 4\n", + "Looking for paths with length: 3 for node SMAD3_S423 and JUN_S63\n", + "i_search = 4\n", + "Looking for paths with length: 4 for node SMAD3_S423 and JUN_S63\n", + "looking for paths in the network with length: 0 for node SMAD3_S423 and EGFR_Y1068\n", + "looking for paths in the network with length: 1 for node SMAD3_S423 and EGFR_Y1068\n", + "looking for paths in the network with length: 2 for node SMAD3_S423 and EGFR_Y1068\n", + "looking for paths in the network with length: 3 for node SMAD3_S423 and EGFR_Y1068\n", + "looking for paths in the network with length: 4 for node SMAD3_S423 and EGFR_Y1068\n", + "looking for paths in the network with length: 5 for node SMAD3_S423 and EGFR_Y1068\n", + "looking for paths in the network with length: 6 for node SMAD3_S423 and EGFR_Y1068\n", + "looking for paths in the network with length: 7 for node SMAD3_S423 and EGFR_Y1068\n", + "looking for paths in the network with length: 8 for node SMAD3_S423 and EGFR_Y1068\n", + "looking for paths in the network with length: 9 for node SMAD3_S423 and EGFR_Y1068\n", + "looking for paths in the network with length: 10 for node SMAD3_S423 and EGFR_Y1068\n", + "i_search = 4\n", + "Looking for paths with length: 0 for node SMAD3_S423 and EGFR_Y1068\n", + "i_search = 4\n", + "Looking for paths with length: 1 for node SMAD3_S423 and EGFR_Y1068\n", + "i_search = 4\n", + "Looking for paths with length: 2 for node SMAD3_S423 and EGFR_Y1068\n", + "i_search = 4\n", + "Looking for paths with length: 3 for node SMAD3_S423 and EGFR_Y1068\n", + "i_search = 4\n", + "Looking for paths with length: 4 for node SMAD3_S423 and EGFR_Y1068\n", + "looking for paths in the network with length: 0 for node SMAD3_S423 and MAPK3_T202\n", + "looking for paths in the network with length: 1 for node SMAD3_S423 and MAPK3_T202\n", + "looking for paths in the network with length: 2 for node SMAD3_S423 and MAPK3_T202\n", + "looking for paths in the network with length: 3 for node SMAD3_S423 and MAPK3_T202\n", + "looking for paths in the network with length: 4 for node SMAD3_S423 and MAPK3_T202\n", + "looking for paths in the network with length: 5 for node SMAD3_S423 and MAPK3_T202\n", + "looking for paths in the network with length: 6 for node SMAD3_S423 and MAPK3_T202\n", + "looking for paths in the network with length: 7 for node SMAD3_S423 and MAPK3_T202\n", + "looking for paths in the network with length: 8 for node SMAD3_S423 and MAPK3_T202\n", + "looking for paths in the network with length: 9 for node SMAD3_S423 and MAPK3_T202\n", + "looking for paths in the network with length: 10 for node SMAD3_S423 and MAPK3_T202\n", + "i_search = 4\n", + "Looking for paths with length: 0 for node SMAD3_S423 and MAPK3_T202\n", + "i_search = 4\n", + "Looking for paths with length: 1 for node SMAD3_S423 and MAPK3_T202\n", + "i_search = 4\n", + "Looking for paths with length: 2 for node SMAD3_S423 and MAPK3_T202\n", + "i_search = 4\n", + "Looking for paths with length: 3 for node SMAD3_S423 and MAPK3_T202\n", + "i_search = 4\n", + "Looking for paths with length: 4 for node SMAD3_S423 and MAPK3_T202\n", + "looking for paths in the network with length: 0 for node SMAD3_S423 and MAPK3_Y204\n", + "looking for paths in the network with length: 1 for node SMAD3_S423 and MAPK3_Y204\n", + "looking for paths in the network with length: 2 for node SMAD3_S423 and MAPK3_Y204\n", + "looking for paths in the network with length: 3 for node SMAD3_S423 and MAPK3_Y204\n", + "looking for paths in the network with length: 4 for node SMAD3_S423 and MAPK3_Y204\n", + "looking for paths in the network with length: 5 for node SMAD3_S423 and MAPK3_Y204\n", + "looking for paths in the network with length: 6 for node SMAD3_S423 and MAPK3_Y204\n", + "looking for paths in the network with length: 7 for node SMAD3_S423 and MAPK3_Y204\n", + "looking for paths in the network with length: 8 for node SMAD3_S423 and MAPK3_Y204\n", + "looking for paths in the network with length: 9 for node SMAD3_S423 and MAPK3_Y204\n", + "looking for paths in the network with length: 10 for node SMAD3_S423 and MAPK3_Y204\n", + "i_search = 4\n", + "Looking for paths with length: 0 for node SMAD3_S423 and MAPK3_Y204\n", + "i_search = 4\n", + "Looking for paths with length: 1 for node SMAD3_S423 and MAPK3_Y204\n", + "i_search = 4\n", + "Looking for paths with length: 2 for node SMAD3_S423 and MAPK3_Y204\n", + "i_search = 4\n", + "Looking for paths with length: 3 for node SMAD3_S423 and MAPK3_Y204\n", + "i_search = 4\n", + "Looking for paths with length: 4 for node SMAD3_S423 and MAPK3_Y204\n", + "looking for paths in the network with length: 0 for node SMAD3_S423 and PTPN11_Y542\n", + "looking for paths in the network with length: 1 for node SMAD3_S423 and PTPN11_Y542\n", + "looking for paths in the network with length: 2 for node SMAD3_S423 and PTPN11_Y542\n", + "looking for paths in the network with length: 3 for node SMAD3_S423 and PTPN11_Y542\n", + "looking for paths in the network with length: 4 for node SMAD3_S423 and PTPN11_Y542\n", + "looking for paths in the network with length: 5 for node SMAD3_S423 and PTPN11_Y542\n", + "looking for paths in the network with length: 6 for node SMAD3_S423 and PTPN11_Y542\n", + "looking for paths in the network with length: 7 for node SMAD3_S423 and PTPN11_Y542\n", + "looking for paths in the network with length: 8 for node SMAD3_S423 and PTPN11_Y542\n", + "looking for paths in the network with length: 9 for node SMAD3_S423 and PTPN11_Y542\n", + "looking for paths in the network with length: 10 for node SMAD3_S423 and PTPN11_Y542\n", + "i_search = 4\n", + "Looking for paths with length: 0 for node SMAD3_S423 and PTPN11_Y542\n", + "i_search = 4\n", + "Looking for paths with length: 1 for node SMAD3_S423 and PTPN11_Y542\n", + "i_search = 4\n", + "Looking for paths with length: 2 for node SMAD3_S423 and PTPN11_Y542\n", + "i_search = 4\n", + "Looking for paths with length: 3 for node SMAD3_S423 and PTPN11_Y542\n", + "i_search = 4\n", + "Looking for paths with length: 4 for node SMAD3_S423 and PTPN11_Y542\n", + "looking for paths in the network with length: 0 for node SMAD3_S423 and STAT3_Y705\n", + "looking for paths in the network with length: 1 for node SMAD3_S423 and STAT3_Y705\n", + "looking for paths in the network with length: 2 for node SMAD3_S423 and STAT3_Y705\n", + "looking for paths in the network with length: 3 for node SMAD3_S423 and STAT3_Y705\n", + "looking for paths in the network with length: 4 for node SMAD3_S423 and STAT3_Y705\n", + "looking for paths in the network with length: 5 for node SMAD3_S423 and STAT3_Y705\n", + "looking for paths in the network with length: 6 for node SMAD3_S423 and STAT3_Y705\n", + "looking for paths in the network with length: 7 for node SMAD3_S423 and STAT3_Y705\n", + "looking for paths in the network with length: 8 for node SMAD3_S423 and STAT3_Y705\n", + "looking for paths in the network with length: 9 for node SMAD3_S423 and STAT3_Y705\n", + "looking for paths in the network with length: 10 for node SMAD3_S423 and STAT3_Y705\n", + "i_search = 4\n", + "Looking for paths with length: 0 for node SMAD3_S423 and STAT3_Y705\n", + "i_search = 4\n", + "Looking for paths with length: 1 for node SMAD3_S423 and STAT3_Y705\n", + "i_search = 4\n", + "Looking for paths with length: 2 for node SMAD3_S423 and STAT3_Y705\n", + "i_search = 4\n", + "Looking for paths with length: 3 for node SMAD3_S423 and STAT3_Y705\n", + "i_search = 4\n", + "Looking for paths with length: 4 for node SMAD3_S423 and STAT3_Y705\n", + "looking for paths in the network with length: 0 for node SMAD3_S423 and CHEK2_T68\n", + "looking for paths in the network with length: 1 for node SMAD3_S423 and CHEK2_T68\n", + "looking for paths in the network with length: 2 for node SMAD3_S423 and CHEK2_T68\n", + "looking for paths in the network with length: 3 for node SMAD3_S423 and CHEK2_T68\n", + "looking for paths in the network with length: 4 for node SMAD3_S423 and CHEK2_T68\n", + "looking for paths in the network with length: 5 for node SMAD3_S423 and CHEK2_T68\n", + "looking for paths in the network with length: 6 for node SMAD3_S423 and CHEK2_T68\n", + "looking for paths in the network with length: 7 for node SMAD3_S423 and CHEK2_T68\n", + "looking for paths in the network with length: 8 for node SMAD3_S423 and CHEK2_T68\n", + "looking for paths in the network with length: 9 for node SMAD3_S423 and CHEK2_T68\n", + "looking for paths in the network with length: 10 for node SMAD3_S423 and CHEK2_T68\n", + "i_search = 4\n", + "Looking for paths with length: 0 for node SMAD3_S423 and CHEK2_T68\n", + "i_search = 4\n", + "Looking for paths with length: 1 for node SMAD3_S423 and CHEK2_T68\n", + "i_search = 4\n", + "Looking for paths with length: 2 for node SMAD3_S423 and CHEK2_T68\n", + "i_search = 4\n", + "Looking for paths with length: 3 for node SMAD3_S423 and CHEK2_T68\n", + "i_search = 4\n", + "Looking for paths with length: 4 for node SMAD3_S423 and CHEK2_T68\n", + "looking for paths in the network with length: 0 for node SMAD3_S423 and RELA_S536\n", + "looking for paths in the network with length: 1 for node SMAD3_S423 and RELA_S536\n", + "looking for paths in the network with length: 2 for node SMAD3_S423 and RELA_S536\n", + "looking for paths in the network with length: 3 for node SMAD3_S423 and RELA_S536\n", + "looking for paths in the network with length: 4 for node SMAD3_S423 and RELA_S536\n", + "looking for paths in the network with length: 5 for node SMAD3_S423 and RELA_S536\n", + "looking for paths in the network with length: 6 for node SMAD3_S423 and RELA_S536\n", + "looking for paths in the network with length: 7 for node SMAD3_S423 and RELA_S536\n", + "looking for paths in the network with length: 8 for node SMAD3_S423 and RELA_S536\n", + "looking for paths in the network with length: 9 for node SMAD3_S423 and RELA_S536\n", + "looking for paths in the network with length: 10 for node SMAD3_S423 and RELA_S536\n", + "i_search = 4\n", + "Looking for paths with length: 0 for node SMAD3_S423 and RELA_S536\n", + "i_search = 4\n", + "Looking for paths with length: 1 for node SMAD3_S423 and RELA_S536\n", + "i_search = 4\n", + "Looking for paths with length: 2 for node SMAD3_S423 and RELA_S536\n", + "i_search = 4\n", + "Looking for paths with length: 3 for node SMAD3_S423 and RELA_S536\n", + "i_search = 4\n", + "Looking for paths with length: 4 for node SMAD3_S423 and RELA_S536\n", + "looking for paths in the network with length: 0 for node SMAD3_S423 and MARCKS_S170\n", + "looking for paths in the network with length: 1 for node SMAD3_S423 and MARCKS_S170\n", + "looking for paths in the network with length: 2 for node SMAD3_S423 and MARCKS_S170\n", + "looking for paths in the network with length: 3 for node SMAD3_S423 and MARCKS_S170\n", + "looking for paths in the network with length: 4 for node SMAD3_S423 and MARCKS_S170\n", + "looking for paths in the network with length: 5 for node SMAD3_S423 and MARCKS_S170\n", + "looking for paths in the network with length: 6 for node SMAD3_S423 and MARCKS_S170\n", + "looking for paths in the network with length: 7 for node SMAD3_S423 and MARCKS_S170\n", + "looking for paths in the network with length: 8 for node SMAD3_S423 and MARCKS_S170\n", + "looking for paths in the network with length: 9 for node SMAD3_S423 and MARCKS_S170\n", + "looking for paths in the network with length: 10 for node SMAD3_S423 and MARCKS_S170\n", + "i_search = 4\n", + "Looking for paths with length: 0 for node SMAD3_S423 and MARCKS_S170\n", + "i_search = 4\n", + "Looking for paths with length: 1 for node SMAD3_S423 and MARCKS_S170\n", + "i_search = 4\n", + "Looking for paths with length: 2 for node SMAD3_S423 and MARCKS_S170\n", + "i_search = 4\n", + "Looking for paths with length: 3 for node SMAD3_S423 and MARCKS_S170\n", + "i_search = 4\n", + "Looking for paths with length: 4 for node SMAD3_S423 and MARCKS_S170\n", + "looking for paths in the network with length: 0 for node SMAD3_S423 and SMAD3\n", + "looking for paths in the network with length: 1 for node SMAD3_S423 and SMAD3\n", + "looking for paths in the network with length: 2 for node SMAD3_S423 and SMAD3\n", + "looking for paths in the network with length: 3 for node SMAD3_S423 and SMAD3\n", + "looking for paths in the network with length: 4 for node SMAD3_S423 and SMAD3\n", + "looking for paths in the network with length: 5 for node SMAD3_S423 and SMAD3\n", + "looking for paths in the network with length: 6 for node SMAD3_S423 and SMAD3\n", + "looking for paths in the network with length: 7 for node SMAD3_S423 and SMAD3\n", + "looking for paths in the network with length: 8 for node SMAD3_S423 and SMAD3\n", + "looking for paths in the network with length: 9 for node SMAD3_S423 and SMAD3\n", + "looking for paths in the network with length: 10 for node SMAD3_S423 and SMAD3\n", + "i_search = 4\n", + "Looking for paths with length: 0 for node SMAD3_S423 and SMAD3\n", + "i_search = 4\n", + "Looking for paths with length: 1 for node SMAD3_S423 and SMAD3\n", + "i_search = 4\n", + "Looking for paths with length: 2 for node SMAD3_S423 and SMAD3\n", + "i_search = 4\n", + "Looking for paths with length: 3 for node SMAD3_S423 and SMAD3\n", + "i_search = 4\n", + "Looking for paths with length: 4 for node SMAD3_S423 and SMAD3\n", + "looking for paths in the network with length: 0 for node SMAD3_S423 and TP53\n", + "looking for paths in the network with length: 1 for node SMAD3_S423 and TP53\n", + "looking for paths in the network with length: 2 for node SMAD3_S423 and TP53\n", + "looking for paths in the network with length: 3 for node SMAD3_S423 and TP53\n", + "looking for paths in the network with length: 4 for node SMAD3_S423 and TP53\n", + "looking for paths in the network with length: 5 for node SMAD3_S423 and TP53\n", + "looking for paths in the network with length: 6 for node SMAD3_S423 and TP53\n", + "looking for paths in the network with length: 7 for node SMAD3_S423 and TP53\n", + "looking for paths in the network with length: 8 for node SMAD3_S423 and TP53\n", + "looking for paths in the network with length: 9 for node SMAD3_S423 and TP53\n", + "looking for paths in the network with length: 10 for node SMAD3_S423 and TP53\n", + "i_search = 4\n", + "Looking for paths with length: 0 for node SMAD3_S423 and TP53\n", + "i_search = 4\n", + "Looking for paths with length: 1 for node SMAD3_S423 and TP53\n", + "i_search = 4\n", + "Looking for paths with length: 2 for node SMAD3_S423 and TP53\n", + "i_search = 4\n", + "Looking for paths with length: 3 for node SMAD3_S423 and TP53\n", + "i_search = 4\n", + "Looking for paths with length: 4 for node SMAD3_S423 and TP53\n", + "looking for paths in the network with length: 0 for node SMAD3_S423 and AKT1S1\n", + "looking for paths in the network with length: 1 for node SMAD3_S423 and AKT1S1\n", + "looking for paths in the network with length: 2 for node SMAD3_S423 and AKT1S1\n", + "looking for paths in the network with length: 3 for node SMAD3_S423 and AKT1S1\n", + "looking for paths in the network with length: 4 for node SMAD3_S423 and AKT1S1\n", + "looking for paths in the network with length: 5 for node SMAD3_S423 and AKT1S1\n", + "looking for paths in the network with length: 6 for node SMAD3_S423 and AKT1S1\n", + "looking for paths in the network with length: 7 for node SMAD3_S423 and AKT1S1\n", + "looking for paths in the network with length: 8 for node SMAD3_S423 and AKT1S1\n", + "looking for paths in the network with length: 9 for node SMAD3_S423 and AKT1S1\n", + "looking for paths in the network with length: 10 for node SMAD3_S423 and AKT1S1\n", + "i_search = 4\n", + "Looking for paths with length: 0 for node SMAD3_S423 and AKT1S1\n", + "i_search = 4\n", + "Looking for paths with length: 1 for node SMAD3_S423 and AKT1S1\n", + "i_search = 4\n", + "Looking for paths with length: 2 for node SMAD3_S423 and AKT1S1\n", + "i_search = 4\n", + "Looking for paths with length: 3 for node SMAD3_S423 and AKT1S1\n", + "i_search = 4\n", + "Looking for paths with length: 4 for node SMAD3_S423 and AKT1S1\n", + "looking for paths in the network with length: 0 for node SMAD3_S423 and GSK3B\n", + "looking for paths in the network with length: 1 for node SMAD3_S423 and GSK3B\n", + "looking for paths in the network with length: 2 for node SMAD3_S423 and GSK3B\n", + "looking for paths in the network with length: 3 for node SMAD3_S423 and GSK3B\n", + "looking for paths in the network with length: 4 for node SMAD3_S423 and GSK3B\n", + "looking for paths in the network with length: 5 for node SMAD3_S423 and GSK3B\n", + "looking for paths in the network with length: 6 for node SMAD3_S423 and GSK3B\n", + "looking for paths in the network with length: 7 for node SMAD3_S423 and GSK3B\n", + "looking for paths in the network with length: 8 for node SMAD3_S423 and GSK3B\n", + "looking for paths in the network with length: 9 for node SMAD3_S423 and GSK3B\n", + "looking for paths in the network with length: 10 for node SMAD3_S423 and GSK3B\n", + "i_search = 4\n", + "Looking for paths with length: 0 for node SMAD3_S423 and GSK3B\n", + "i_search = 4\n", + "Looking for paths with length: 1 for node SMAD3_S423 and GSK3B\n", + "i_search = 4\n", + "Looking for paths with length: 2 for node SMAD3_S423 and GSK3B\n", + "i_search = 4\n", + "Looking for paths with length: 3 for node SMAD3_S423 and GSK3B\n", + "i_search = 4\n", + "Looking for paths with length: 4 for node SMAD3_S423 and GSK3B\n", + "looking for paths in the network with length: 0 for node SMAD3_S423 and AKT1\n", + "looking for paths in the network with length: 1 for node SMAD3_S423 and AKT1\n", + "looking for paths in the network with length: 2 for node SMAD3_S423 and AKT1\n", + "looking for paths in the network with length: 3 for node SMAD3_S423 and AKT1\n", + "looking for paths in the network with length: 4 for node SMAD3_S423 and AKT1\n", + "looking for paths in the network with length: 5 for node SMAD3_S423 and AKT1\n", + "looking for paths in the network with length: 6 for node SMAD3_S423 and AKT1\n", + "looking for paths in the network with length: 7 for node SMAD3_S423 and AKT1\n", + "looking for paths in the network with length: 8 for node SMAD3_S423 and AKT1\n", + "looking for paths in the network with length: 9 for node SMAD3_S423 and AKT1\n", + "looking for paths in the network with length: 10 for node SMAD3_S423 and AKT1\n", + "i_search = 4\n", + "Looking for paths with length: 0 for node SMAD3_S423 and AKT1\n", + "i_search = 4\n", + "Looking for paths with length: 1 for node SMAD3_S423 and AKT1\n", + "i_search = 4\n", + "Looking for paths with length: 2 for node SMAD3_S423 and AKT1\n", + "i_search = 4\n", + "Looking for paths with length: 3 for node SMAD3_S423 and AKT1\n", + "i_search = 4\n", + "Looking for paths with length: 4 for node SMAD3_S423 and AKT1\n", + "looking for paths in the network with length: 0 for node SMAD3_S423 and HSPB1\n", + "looking for paths in the network with length: 1 for node SMAD3_S423 and HSPB1\n", + "looking for paths in the network with length: 2 for node SMAD3_S423 and HSPB1\n", + "looking for paths in the network with length: 3 for node SMAD3_S423 and HSPB1\n", + "looking for paths in the network with length: 4 for node SMAD3_S423 and HSPB1\n", + "looking for paths in the network with length: 5 for node SMAD3_S423 and HSPB1\n", + "looking for paths in the network with length: 6 for node SMAD3_S423 and HSPB1\n", + "looking for paths in the network with length: 7 for node SMAD3_S423 and HSPB1\n", + "looking for paths in the network with length: 8 for node SMAD3_S423 and HSPB1\n", + "looking for paths in the network with length: 9 for node SMAD3_S423 and HSPB1\n", + "looking for paths in the network with length: 10 for node SMAD3_S423 and HSPB1\n", + "i_search = 4\n", + "Looking for paths with length: 0 for node SMAD3_S423 and HSPB1\n", + "i_search = 4\n", + "Looking for paths with length: 1 for node SMAD3_S423 and HSPB1\n", + "i_search = 4\n", + "Looking for paths with length: 2 for node SMAD3_S423 and HSPB1\n", + "i_search = 4\n", + "Looking for paths with length: 3 for node SMAD3_S423 and HSPB1\n", + "i_search = 4\n", + "Looking for paths with length: 4 for node SMAD3_S423 and HSPB1\n", + "looking for paths in the network with length: 0 for node SMAD3_S423 and MAPK14\n", + "looking for paths in the network with length: 1 for node SMAD3_S423 and MAPK14\n", + "looking for paths in the network with length: 2 for node SMAD3_S423 and MAPK14\n", + "looking for paths in the network with length: 3 for node SMAD3_S423 and MAPK14\n", + "looking for paths in the network with length: 4 for node SMAD3_S423 and MAPK14\n", + "looking for paths in the network with length: 5 for node SMAD3_S423 and MAPK14\n", + "looking for paths in the network with length: 6 for node SMAD3_S423 and MAPK14\n", + "looking for paths in the network with length: 7 for node SMAD3_S423 and MAPK14\n", + "looking for paths in the network with length: 8 for node SMAD3_S423 and MAPK14\n", + "looking for paths in the network with length: 9 for node SMAD3_S423 and MAPK14\n", + "looking for paths in the network with length: 10 for node SMAD3_S423 and MAPK14\n", + "i_search = 4\n", + "Looking for paths with length: 0 for node SMAD3_S423 and MAPK14\n", + "i_search = 4\n", + "Looking for paths with length: 1 for node SMAD3_S423 and MAPK14\n", + "i_search = 4\n", + "Looking for paths with length: 2 for node SMAD3_S423 and MAPK14\n", + "i_search = 4\n", + "Looking for paths with length: 3 for node SMAD3_S423 and MAPK14\n", + "i_search = 4\n", + "Looking for paths with length: 4 for node SMAD3_S423 and MAPK14\n", + "looking for paths in the network with length: 0 for node SMAD3_S423 and MAP2K1\n", + "looking for paths in the network with length: 1 for node SMAD3_S423 and MAP2K1\n", + "looking for paths in the network with length: 2 for node SMAD3_S423 and MAP2K1\n", + "looking for paths in the network with length: 3 for node SMAD3_S423 and MAP2K1\n", + "looking for paths in the network with length: 4 for node SMAD3_S423 and MAP2K1\n", + "looking for paths in the network with length: 5 for node SMAD3_S423 and MAP2K1\n", + "looking for paths in the network with length: 6 for node SMAD3_S423 and MAP2K1\n", + "looking for paths in the network with length: 7 for node SMAD3_S423 and MAP2K1\n", + "looking for paths in the network with length: 8 for node SMAD3_S423 and MAP2K1\n", + "looking for paths in the network with length: 9 for node SMAD3_S423 and MAP2K1\n", + "looking for paths in the network with length: 10 for node SMAD3_S423 and MAP2K1\n", + "i_search = 4\n", + "Looking for paths with length: 0 for node SMAD3_S423 and MAP2K1\n", + "i_search = 4\n", + "Looking for paths with length: 1 for node SMAD3_S423 and MAP2K1\n", + "i_search = 4\n", + "Looking for paths with length: 2 for node SMAD3_S423 and MAP2K1\n", + "i_search = 4\n", + "Looking for paths with length: 3 for node SMAD3_S423 and MAP2K1\n", + "i_search = 4\n", + "Looking for paths with length: 4 for node SMAD3_S423 and MAP2K1\n", + "looking for paths in the network with length: 0 for node SMAD3_S423 and RPS6KA1\n", + "looking for paths in the network with length: 1 for node SMAD3_S423 and RPS6KA1\n", + "looking for paths in the network with length: 2 for node SMAD3_S423 and RPS6KA1\n", + "looking for paths in the network with length: 3 for node SMAD3_S423 and RPS6KA1\n", + "looking for paths in the network with length: 4 for node SMAD3_S423 and RPS6KA1\n", + "looking for paths in the network with length: 5 for node SMAD3_S423 and RPS6KA1\n", + "looking for paths in the network with length: 6 for node SMAD3_S423 and RPS6KA1\n", + "looking for paths in the network with length: 7 for node SMAD3_S423 and RPS6KA1\n", + "looking for paths in the network with length: 8 for node SMAD3_S423 and RPS6KA1\n", + "looking for paths in the network with length: 9 for node SMAD3_S423 and RPS6KA1\n", + "looking for paths in the network with length: 10 for node SMAD3_S423 and RPS6KA1\n", + "i_search = 4\n", + "Looking for paths with length: 0 for node SMAD3_S423 and RPS6KA1\n", + "i_search = 4\n", + "Looking for paths with length: 1 for node SMAD3_S423 and RPS6KA1\n", + "i_search = 4\n", + "Looking for paths with length: 2 for node SMAD3_S423 and RPS6KA1\n", + "i_search = 4\n", + "Looking for paths with length: 3 for node SMAD3_S423 and RPS6KA1\n", + "i_search = 4\n", + "Looking for paths with length: 4 for node SMAD3_S423 and RPS6KA1\n", + "looking for paths in the network with length: 0 for node SMAD3_S423 and CREB1\n", + "looking for paths in the network with length: 1 for node SMAD3_S423 and CREB1\n", + "looking for paths in the network with length: 2 for node SMAD3_S423 and CREB1\n", + "looking for paths in the network with length: 3 for node SMAD3_S423 and CREB1\n", + "looking for paths in the network with length: 4 for node SMAD3_S423 and CREB1\n", + "looking for paths in the network with length: 5 for node SMAD3_S423 and CREB1\n", + "looking for paths in the network with length: 6 for node SMAD3_S423 and CREB1\n", + "looking for paths in the network with length: 7 for node SMAD3_S423 and CREB1\n", + "looking for paths in the network with length: 8 for node SMAD3_S423 and CREB1\n", + "looking for paths in the network with length: 9 for node SMAD3_S423 and CREB1\n", + "looking for paths in the network with length: 10 for node SMAD3_S423 and CREB1\n", + "i_search = 4\n", + "Looking for paths with length: 0 for node SMAD3_S423 and CREB1\n", + "i_search = 4\n", + "Looking for paths with length: 1 for node SMAD3_S423 and CREB1\n", + "i_search = 4\n", + "Looking for paths with length: 2 for node SMAD3_S423 and CREB1\n", + "i_search = 4\n", + "Looking for paths with length: 3 for node SMAD3_S423 and CREB1\n", + "i_search = 4\n", + "Looking for paths with length: 4 for node SMAD3_S423 and CREB1\n", + "looking for paths in the network with length: 0 for node SMAD3_S423 and NFKBIA\n", + "looking for paths in the network with length: 1 for node SMAD3_S423 and NFKBIA\n", + "looking for paths in the network with length: 2 for node SMAD3_S423 and NFKBIA\n", + "looking for paths in the network with length: 3 for node SMAD3_S423 and NFKBIA\n", + "looking for paths in the network with length: 4 for node SMAD3_S423 and NFKBIA\n", + "looking for paths in the network with length: 5 for node SMAD3_S423 and NFKBIA\n", + "looking for paths in the network with length: 6 for node SMAD3_S423 and NFKBIA\n", + "looking for paths in the network with length: 7 for node SMAD3_S423 and NFKBIA\n", + "looking for paths in the network with length: 8 for node SMAD3_S423 and NFKBIA\n", + "looking for paths in the network with length: 9 for node SMAD3_S423 and NFKBIA\n", + "looking for paths in the network with length: 10 for node SMAD3_S423 and NFKBIA\n", + "i_search = 4\n", + "Looking for paths with length: 0 for node SMAD3_S423 and NFKBIA\n", + "i_search = 4\n", + "Looking for paths with length: 1 for node SMAD3_S423 and NFKBIA\n", + "i_search = 4\n", + "Looking for paths with length: 2 for node SMAD3_S423 and NFKBIA\n", + "i_search = 4\n", + "Looking for paths with length: 3 for node SMAD3_S423 and NFKBIA\n", + "i_search = 4\n", + "Looking for paths with length: 4 for node SMAD3_S423 and NFKBIA\n", + "looking for paths in the network with length: 0 for node SMAD3_S423 and MTOR\n", + "looking for paths in the network with length: 1 for node SMAD3_S423 and MTOR\n", + "looking for paths in the network with length: 2 for node SMAD3_S423 and MTOR\n", + "looking for paths in the network with length: 3 for node SMAD3_S423 and MTOR\n", + "looking for paths in the network with length: 4 for node SMAD3_S423 and MTOR\n", + "looking for paths in the network with length: 5 for node SMAD3_S423 and MTOR\n", + "looking for paths in the network with length: 6 for node SMAD3_S423 and MTOR\n", + "looking for paths in the network with length: 7 for node SMAD3_S423 and MTOR\n", + "looking for paths in the network with length: 8 for node SMAD3_S423 and MTOR\n", + "looking for paths in the network with length: 9 for node SMAD3_S423 and MTOR\n", + "looking for paths in the network with length: 10 for node SMAD3_S423 and MTOR\n", + "i_search = 4\n", + "Looking for paths with length: 0 for node SMAD3_S423 and MTOR\n", + "i_search = 4\n", + "Looking for paths with length: 1 for node SMAD3_S423 and MTOR\n", + "i_search = 4\n", + "Looking for paths with length: 2 for node SMAD3_S423 and MTOR\n", + "i_search = 4\n", + "Looking for paths with length: 3 for node SMAD3_S423 and MTOR\n", + "i_search = 4\n", + "Looking for paths with length: 4 for node SMAD3_S423 and MTOR\n", + "looking for paths in the network with length: 0 for node SMAD3_S423 and JUN\n", + "looking for paths in the network with length: 1 for node SMAD3_S423 and JUN\n", + "looking for paths in the network with length: 2 for node SMAD3_S423 and JUN\n", + "looking for paths in the network with length: 3 for node SMAD3_S423 and JUN\n", + "looking for paths in the network with length: 4 for node SMAD3_S423 and JUN\n", + "looking for paths in the network with length: 5 for node SMAD3_S423 and JUN\n", + "looking for paths in the network with length: 6 for node SMAD3_S423 and JUN\n", + "looking for paths in the network with length: 7 for node SMAD3_S423 and JUN\n", + "looking for paths in the network with length: 8 for node SMAD3_S423 and JUN\n", + "looking for paths in the network with length: 9 for node SMAD3_S423 and JUN\n", + "looking for paths in the network with length: 10 for node SMAD3_S423 and JUN\n", + "i_search = 4\n", + "Looking for paths with length: 0 for node SMAD3_S423 and JUN\n", + "i_search = 4\n", + "Looking for paths with length: 1 for node SMAD3_S423 and JUN\n", + "i_search = 4\n", + "Looking for paths with length: 2 for node SMAD3_S423 and JUN\n", + "i_search = 4\n", + "Looking for paths with length: 3 for node SMAD3_S423 and JUN\n", + "i_search = 4\n", + "Looking for paths with length: 4 for node SMAD3_S423 and JUN\n", + "looking for paths in the network with length: 0 for node SMAD3_S423 and EGFR\n", + "looking for paths in the network with length: 1 for node SMAD3_S423 and EGFR\n", + "looking for paths in the network with length: 2 for node SMAD3_S423 and EGFR\n", + "looking for paths in the network with length: 3 for node SMAD3_S423 and EGFR\n", + "looking for paths in the network with length: 4 for node SMAD3_S423 and EGFR\n", + "looking for paths in the network with length: 5 for node SMAD3_S423 and EGFR\n", + "looking for paths in the network with length: 6 for node SMAD3_S423 and EGFR\n", + "looking for paths in the network with length: 7 for node SMAD3_S423 and EGFR\n", + "looking for paths in the network with length: 8 for node SMAD3_S423 and EGFR\n", + "looking for paths in the network with length: 9 for node SMAD3_S423 and EGFR\n", + "looking for paths in the network with length: 10 for node SMAD3_S423 and EGFR\n", + "i_search = 4\n", + "Looking for paths with length: 0 for node SMAD3_S423 and EGFR\n", + "i_search = 4\n", + "Looking for paths with length: 1 for node SMAD3_S423 and EGFR\n", + "i_search = 4\n", + "Looking for paths with length: 2 for node SMAD3_S423 and EGFR\n", + "i_search = 4\n", + "Looking for paths with length: 3 for node SMAD3_S423 and EGFR\n", + "i_search = 4\n", + "Looking for paths with length: 4 for node SMAD3_S423 and EGFR\n", + "looking for paths in the network with length: 0 for node SMAD3_S423 and MAPK3\n", + "looking for paths in the network with length: 1 for node SMAD3_S423 and MAPK3\n", + "looking for paths in the network with length: 2 for node SMAD3_S423 and MAPK3\n", + "looking for paths in the network with length: 3 for node SMAD3_S423 and MAPK3\n", + "looking for paths in the network with length: 4 for node SMAD3_S423 and MAPK3\n", + "looking for paths in the network with length: 5 for node SMAD3_S423 and MAPK3\n", + "looking for paths in the network with length: 6 for node SMAD3_S423 and MAPK3\n", + "looking for paths in the network with length: 7 for node SMAD3_S423 and MAPK3\n", + "looking for paths in the network with length: 8 for node SMAD3_S423 and MAPK3\n", + "looking for paths in the network with length: 9 for node SMAD3_S423 and MAPK3\n", + "looking for paths in the network with length: 10 for node SMAD3_S423 and MAPK3\n", + "i_search = 4\n", + "Looking for paths with length: 0 for node SMAD3_S423 and MAPK3\n", + "i_search = 4\n", + "Looking for paths with length: 1 for node SMAD3_S423 and MAPK3\n", + "i_search = 4\n", + "Looking for paths with length: 2 for node SMAD3_S423 and MAPK3\n", + "i_search = 4\n", + "Looking for paths with length: 3 for node SMAD3_S423 and MAPK3\n", + "i_search = 4\n", + "Looking for paths with length: 4 for node SMAD3_S423 and MAPK3\n", + "looking for paths in the network with length: 0 for node SMAD3_S423 and PTPN11\n", + "looking for paths in the network with length: 1 for node SMAD3_S423 and PTPN11\n", + "looking for paths in the network with length: 2 for node SMAD3_S423 and PTPN11\n", + "looking for paths in the network with length: 3 for node SMAD3_S423 and PTPN11\n", + "looking for paths in the network with length: 4 for node SMAD3_S423 and PTPN11\n", + "looking for paths in the network with length: 5 for node SMAD3_S423 and PTPN11\n", + "looking for paths in the network with length: 6 for node SMAD3_S423 and PTPN11\n", + "looking for paths in the network with length: 7 for node SMAD3_S423 and PTPN11\n", + "looking for paths in the network with length: 8 for node SMAD3_S423 and PTPN11\n", + "looking for paths in the network with length: 9 for node SMAD3_S423 and PTPN11\n", + "looking for paths in the network with length: 10 for node SMAD3_S423 and PTPN11\n", + "i_search = 4\n", + "Looking for paths with length: 0 for node SMAD3_S423 and PTPN11\n", + "i_search = 4\n", + "Looking for paths with length: 1 for node SMAD3_S423 and PTPN11\n", + "i_search = 4\n", + "Looking for paths with length: 2 for node SMAD3_S423 and PTPN11\n", + "i_search = 4\n", + "Looking for paths with length: 3 for node SMAD3_S423 and PTPN11\n", + "i_search = 4\n", + "Looking for paths with length: 4 for node SMAD3_S423 and PTPN11\n", + "looking for paths in the network with length: 0 for node SMAD3_S423 and STAT3\n", + "looking for paths in the network with length: 1 for node SMAD3_S423 and STAT3\n", + "looking for paths in the network with length: 2 for node SMAD3_S423 and STAT3\n", + "looking for paths in the network with length: 3 for node SMAD3_S423 and STAT3\n", + "looking for paths in the network with length: 4 for node SMAD3_S423 and STAT3\n", + "looking for paths in the network with length: 5 for node SMAD3_S423 and STAT3\n", + "looking for paths in the network with length: 6 for node SMAD3_S423 and STAT3\n", + "looking for paths in the network with length: 7 for node SMAD3_S423 and STAT3\n", + "looking for paths in the network with length: 8 for node SMAD3_S423 and STAT3\n", + "looking for paths in the network with length: 9 for node SMAD3_S423 and STAT3\n", + "looking for paths in the network with length: 10 for node SMAD3_S423 and STAT3\n", + "i_search = 4\n", + "Looking for paths with length: 0 for node SMAD3_S423 and STAT3\n", + "i_search = 4\n", + "Looking for paths with length: 1 for node SMAD3_S423 and STAT3\n", + "i_search = 4\n", + "Looking for paths with length: 2 for node SMAD3_S423 and STAT3\n", + "i_search = 4\n", + "Looking for paths with length: 3 for node SMAD3_S423 and STAT3\n", + "i_search = 4\n", + "Looking for paths with length: 4 for node SMAD3_S423 and STAT3\n", + "looking for paths in the network with length: 0 for node SMAD3_S423 and CHEK2\n", + "looking for paths in the network with length: 1 for node SMAD3_S423 and CHEK2\n", + "looking for paths in the network with length: 2 for node SMAD3_S423 and CHEK2\n", + "looking for paths in the network with length: 3 for node SMAD3_S423 and CHEK2\n", + "looking for paths in the network with length: 4 for node SMAD3_S423 and CHEK2\n", + "looking for paths in the network with length: 5 for node SMAD3_S423 and CHEK2\n", + "looking for paths in the network with length: 6 for node SMAD3_S423 and CHEK2\n", + "looking for paths in the network with length: 7 for node SMAD3_S423 and CHEK2\n", + "looking for paths in the network with length: 8 for node SMAD3_S423 and CHEK2\n", + "looking for paths in the network with length: 9 for node SMAD3_S423 and CHEK2\n", + "looking for paths in the network with length: 10 for node SMAD3_S423 and CHEK2\n", + "i_search = 4\n", + "Looking for paths with length: 0 for node SMAD3_S423 and CHEK2\n", + "i_search = 4\n", + "Looking for paths with length: 1 for node SMAD3_S423 and CHEK2\n", + "i_search = 4\n", + "Looking for paths with length: 2 for node SMAD3_S423 and CHEK2\n", + "i_search = 4\n", + "Looking for paths with length: 3 for node SMAD3_S423 and CHEK2\n", + "i_search = 4\n", + "Looking for paths with length: 4 for node SMAD3_S423 and CHEK2\n", + "looking for paths in the network with length: 0 for node SMAD3_S423 and RELA\n", + "looking for paths in the network with length: 1 for node SMAD3_S423 and RELA\n", + "looking for paths in the network with length: 2 for node SMAD3_S423 and RELA\n", + "looking for paths in the network with length: 3 for node SMAD3_S423 and RELA\n", + "looking for paths in the network with length: 4 for node SMAD3_S423 and RELA\n", + "looking for paths in the network with length: 5 for node SMAD3_S423 and RELA\n", + "looking for paths in the network with length: 6 for node SMAD3_S423 and RELA\n", + "looking for paths in the network with length: 7 for node SMAD3_S423 and RELA\n", + "looking for paths in the network with length: 8 for node SMAD3_S423 and RELA\n", + "looking for paths in the network with length: 9 for node SMAD3_S423 and RELA\n", + "looking for paths in the network with length: 10 for node SMAD3_S423 and RELA\n", + "i_search = 4\n", + "Looking for paths with length: 0 for node SMAD3_S423 and RELA\n", + "i_search = 4\n", + "Looking for paths with length: 1 for node SMAD3_S423 and RELA\n", + "i_search = 4\n", + "Looking for paths with length: 2 for node SMAD3_S423 and RELA\n", + "i_search = 4\n", + "Looking for paths with length: 3 for node SMAD3_S423 and RELA\n", + "i_search = 4\n", + "Looking for paths with length: 4 for node SMAD3_S423 and RELA\n", + "looking for paths in the network with length: 0 for node SMAD3_S423 and MARCKS\n", + "looking for paths in the network with length: 1 for node SMAD3_S423 and MARCKS\n", + "looking for paths in the network with length: 2 for node SMAD3_S423 and MARCKS\n", + "looking for paths in the network with length: 3 for node SMAD3_S423 and MARCKS\n", + "looking for paths in the network with length: 4 for node SMAD3_S423 and MARCKS\n", + "looking for paths in the network with length: 5 for node SMAD3_S423 and MARCKS\n", + "looking for paths in the network with length: 6 for node SMAD3_S423 and MARCKS\n", + "looking for paths in the network with length: 7 for node SMAD3_S423 and MARCKS\n", + "looking for paths in the network with length: 8 for node SMAD3_S423 and MARCKS\n", + "looking for paths in the network with length: 9 for node SMAD3_S423 and MARCKS\n", + "looking for paths in the network with length: 10 for node SMAD3_S423 and MARCKS\n", + "i_search = 4\n", + "Looking for paths with length: 0 for node SMAD3_S423 and MARCKS\n", + "i_search = 4\n", + "Looking for paths with length: 1 for node SMAD3_S423 and MARCKS\n", + "i_search = 4\n", + "Looking for paths with length: 2 for node SMAD3_S423 and MARCKS\n", + "i_search = 4\n", + "Looking for paths with length: 3 for node SMAD3_S423 and MARCKS\n", + "i_search = 4\n", + "Looking for paths with length: 4 for node SMAD3_S423 and MARCKS\n", + "looking for paths in the network with length: 0 for node SMAD3_S425 and TP53_S15\n", + "looking for paths in the network with length: 1 for node SMAD3_S425 and TP53_S15\n", + "looking for paths in the network with length: 2 for node SMAD3_S425 and TP53_S15\n", + "looking for paths in the network with length: 3 for node SMAD3_S425 and TP53_S15\n", + "looking for paths in the network with length: 4 for node SMAD3_S425 and TP53_S15\n", + "looking for paths in the network with length: 5 for node SMAD3_S425 and TP53_S15\n", + "looking for paths in the network with length: 6 for node SMAD3_S425 and TP53_S15\n", + "looking for paths in the network with length: 7 for node SMAD3_S425 and TP53_S15\n", + "looking for paths in the network with length: 8 for node SMAD3_S425 and TP53_S15\n", + "looking for paths in the network with length: 9 for node SMAD3_S425 and TP53_S15\n", + "looking for paths in the network with length: 10 for node SMAD3_S425 and TP53_S15\n", + "i_search = 4\n", + "Looking for paths with length: 0 for node SMAD3_S425 and TP53_S15\n", + "i_search = 4\n", + "Looking for paths with length: 1 for node SMAD3_S425 and TP53_S15\n", + "i_search = 4\n", + "Looking for paths with length: 2 for node SMAD3_S425 and TP53_S15\n", + "i_search = 4\n", + "Looking for paths with length: 3 for node SMAD3_S425 and TP53_S15\n", + "i_search = 4\n", + "Looking for paths with length: 4 for node SMAD3_S425 and TP53_S15\n", + "looking for paths in the network with length: 0 for node SMAD3_S425 and AKT1S1_T246\n", + "looking for paths in the network with length: 1 for node SMAD3_S425 and AKT1S1_T246\n", + "looking for paths in the network with length: 2 for node SMAD3_S425 and AKT1S1_T246\n", + "looking for paths in the network with length: 3 for node SMAD3_S425 and AKT1S1_T246\n", + "looking for paths in the network with length: 4 for node SMAD3_S425 and AKT1S1_T246\n", + "looking for paths in the network with length: 5 for node SMAD3_S425 and AKT1S1_T246\n", + "looking for paths in the network with length: 6 for node SMAD3_S425 and AKT1S1_T246\n", + "looking for paths in the network with length: 7 for node SMAD3_S425 and AKT1S1_T246\n", + "looking for paths in the network with length: 8 for node SMAD3_S425 and AKT1S1_T246\n", + "looking for paths in the network with length: 9 for node SMAD3_S425 and AKT1S1_T246\n", + "looking for paths in the network with length: 10 for node SMAD3_S425 and AKT1S1_T246\n", + "i_search = 4\n", + "Looking for paths with length: 0 for node SMAD3_S425 and AKT1S1_T246\n", + "i_search = 4\n", + "Looking for paths with length: 1 for node SMAD3_S425 and AKT1S1_T246\n", + "i_search = 4\n", + "Looking for paths with length: 2 for node SMAD3_S425 and AKT1S1_T246\n", + "i_search = 4\n", + "Looking for paths with length: 3 for node SMAD3_S425 and AKT1S1_T246\n", + "i_search = 4\n", + "Looking for paths with length: 4 for node SMAD3_S425 and AKT1S1_T246\n", + "looking for paths in the network with length: 0 for node SMAD3_S425 and GSK3B_S9\n", + "looking for paths in the network with length: 1 for node SMAD3_S425 and GSK3B_S9\n", + "looking for paths in the network with length: 2 for node SMAD3_S425 and GSK3B_S9\n", + "looking for paths in the network with length: 3 for node SMAD3_S425 and GSK3B_S9\n", + "looking for paths in the network with length: 4 for node SMAD3_S425 and GSK3B_S9\n", + "looking for paths in the network with length: 5 for node SMAD3_S425 and GSK3B_S9\n", + "looking for paths in the network with length: 6 for node SMAD3_S425 and GSK3B_S9\n", + "looking for paths in the network with length: 7 for node SMAD3_S425 and GSK3B_S9\n", + "looking for paths in the network with length: 8 for node SMAD3_S425 and GSK3B_S9\n", + "looking for paths in the network with length: 9 for node SMAD3_S425 and GSK3B_S9\n", + "looking for paths in the network with length: 10 for node SMAD3_S425 and GSK3B_S9\n", + "i_search = 4\n", + "Looking for paths with length: 0 for node SMAD3_S425 and GSK3B_S9\n", + "i_search = 4\n", + "Looking for paths with length: 1 for node SMAD3_S425 and GSK3B_S9\n", + "i_search = 4\n", + "Looking for paths with length: 2 for node SMAD3_S425 and GSK3B_S9\n", + "i_search = 4\n", + "Looking for paths with length: 3 for node SMAD3_S425 and GSK3B_S9\n", + "i_search = 4\n", + "Looking for paths with length: 4 for node SMAD3_S425 and GSK3B_S9\n", + "looking for paths in the network with length: 0 for node SMAD3_S425 and GSK3B_S21\n", + "looking for paths in the network with length: 1 for node SMAD3_S425 and GSK3B_S21\n", + "looking for paths in the network with length: 2 for node SMAD3_S425 and GSK3B_S21\n", + "looking for paths in the network with length: 3 for node SMAD3_S425 and GSK3B_S21\n", + "looking for paths in the network with length: 4 for node SMAD3_S425 and GSK3B_S21\n", + "looking for paths in the network with length: 5 for node SMAD3_S425 and GSK3B_S21\n", + "looking for paths in the network with length: 6 for node SMAD3_S425 and GSK3B_S21\n", + "looking for paths in the network with length: 7 for node SMAD3_S425 and GSK3B_S21\n", + "looking for paths in the network with length: 8 for node SMAD3_S425 and GSK3B_S21\n", + "looking for paths in the network with length: 9 for node SMAD3_S425 and GSK3B_S21\n", + "looking for paths in the network with length: 10 for node SMAD3_S425 and GSK3B_S21\n", + "i_search = 4\n", + "Looking for paths with length: 0 for node SMAD3_S425 and GSK3B_S21\n", + "i_search = 4\n", + "Looking for paths with length: 1 for node SMAD3_S425 and GSK3B_S21\n", + "i_search = 4\n", + "Looking for paths with length: 2 for node SMAD3_S425 and GSK3B_S21\n", + "i_search = 4\n", + "Looking for paths with length: 3 for node SMAD3_S425 and GSK3B_S21\n", + "i_search = 4\n", + "Looking for paths with length: 4 for node SMAD3_S425 and GSK3B_S21\n", + "looking for paths in the network with length: 0 for node SMAD3_S425 and AKT1_S473\n", + "looking for paths in the network with length: 1 for node SMAD3_S425 and AKT1_S473\n", + "looking for paths in the network with length: 2 for node SMAD3_S425 and AKT1_S473\n", + "looking for paths in the network with length: 3 for node SMAD3_S425 and AKT1_S473\n", + "looking for paths in the network with length: 4 for node SMAD3_S425 and AKT1_S473\n", + "looking for paths in the network with length: 5 for node SMAD3_S425 and AKT1_S473\n", + "looking for paths in the network with length: 6 for node SMAD3_S425 and AKT1_S473\n", + "looking for paths in the network with length: 7 for node SMAD3_S425 and AKT1_S473\n", + "looking for paths in the network with length: 8 for node SMAD3_S425 and AKT1_S473\n", + "looking for paths in the network with length: 9 for node SMAD3_S425 and AKT1_S473\n", + "looking for paths in the network with length: 10 for node SMAD3_S425 and AKT1_S473\n", + "i_search = 4\n", + "Looking for paths with length: 0 for node SMAD3_S425 and AKT1_S473\n", + "i_search = 4\n", + "Looking for paths with length: 1 for node SMAD3_S425 and AKT1_S473\n", + "i_search = 4\n", + "Looking for paths with length: 2 for node SMAD3_S425 and AKT1_S473\n", + "i_search = 4\n", + "Looking for paths with length: 3 for node SMAD3_S425 and AKT1_S473\n", + "i_search = 4\n", + "Looking for paths with length: 4 for node SMAD3_S425 and AKT1_S473\n", + "looking for paths in the network with length: 0 for node SMAD3_S425 and HSPB1_S78\n", + "looking for paths in the network with length: 1 for node SMAD3_S425 and HSPB1_S78\n", + "looking for paths in the network with length: 2 for node SMAD3_S425 and HSPB1_S78\n", + "looking for paths in the network with length: 3 for node SMAD3_S425 and HSPB1_S78\n", + "looking for paths in the network with length: 4 for node SMAD3_S425 and HSPB1_S78\n", + "looking for paths in the network with length: 5 for node SMAD3_S425 and HSPB1_S78\n", + "looking for paths in the network with length: 6 for node SMAD3_S425 and HSPB1_S78\n", + "looking for paths in the network with length: 7 for node SMAD3_S425 and HSPB1_S78\n", + "looking for paths in the network with length: 8 for node SMAD3_S425 and HSPB1_S78\n", + "looking for paths in the network with length: 9 for node SMAD3_S425 and HSPB1_S78\n", + "looking for paths in the network with length: 10 for node SMAD3_S425 and HSPB1_S78\n", + "i_search = 4\n", + "Looking for paths with length: 0 for node SMAD3_S425 and HSPB1_S78\n", + "i_search = 4\n", + "Looking for paths with length: 1 for node SMAD3_S425 and HSPB1_S78\n", + "i_search = 4\n", + "Looking for paths with length: 2 for node SMAD3_S425 and HSPB1_S78\n", + "i_search = 4\n", + "Looking for paths with length: 3 for node SMAD3_S425 and HSPB1_S78\n", + "i_search = 4\n", + "Looking for paths with length: 4 for node SMAD3_S425 and HSPB1_S78\n", + "looking for paths in the network with length: 0 for node SMAD3_S425 and HSPB1_S82\n", + "looking for paths in the network with length: 1 for node SMAD3_S425 and HSPB1_S82\n", + "looking for paths in the network with length: 2 for node SMAD3_S425 and HSPB1_S82\n", + "looking for paths in the network with length: 3 for node SMAD3_S425 and HSPB1_S82\n", + "looking for paths in the network with length: 4 for node SMAD3_S425 and HSPB1_S82\n", + "looking for paths in the network with length: 5 for node SMAD3_S425 and HSPB1_S82\n", + "looking for paths in the network with length: 6 for node SMAD3_S425 and HSPB1_S82\n", + "looking for paths in the network with length: 7 for node SMAD3_S425 and HSPB1_S82\n", + "looking for paths in the network with length: 8 for node SMAD3_S425 and HSPB1_S82\n", + "looking for paths in the network with length: 9 for node SMAD3_S425 and HSPB1_S82\n", + "looking for paths in the network with length: 10 for node SMAD3_S425 and HSPB1_S82\n", + "i_search = 4\n", + "Looking for paths with length: 0 for node SMAD3_S425 and HSPB1_S82\n", + "i_search = 4\n", + "Looking for paths with length: 1 for node SMAD3_S425 and HSPB1_S82\n", + "i_search = 4\n", + "Looking for paths with length: 2 for node SMAD3_S425 and HSPB1_S82\n", + "i_search = 4\n", + "Looking for paths with length: 3 for node SMAD3_S425 and HSPB1_S82\n", + "i_search = 4\n", + "Looking for paths with length: 4 for node SMAD3_S425 and HSPB1_S82\n", + "looking for paths in the network with length: 0 for node SMAD3_S425 and MAPK14_T180\n", + "looking for paths in the network with length: 1 for node SMAD3_S425 and MAPK14_T180\n", + "looking for paths in the network with length: 2 for node SMAD3_S425 and MAPK14_T180\n", + "looking for paths in the network with length: 3 for node SMAD3_S425 and MAPK14_T180\n", + "looking for paths in the network with length: 4 for node SMAD3_S425 and MAPK14_T180\n", + "looking for paths in the network with length: 5 for node SMAD3_S425 and MAPK14_T180\n", + "looking for paths in the network with length: 6 for node SMAD3_S425 and MAPK14_T180\n", + "looking for paths in the network with length: 7 for node SMAD3_S425 and MAPK14_T180\n", + "looking for paths in the network with length: 8 for node SMAD3_S425 and MAPK14_T180\n", + "looking for paths in the network with length: 9 for node SMAD3_S425 and MAPK14_T180\n", + "looking for paths in the network with length: 10 for node SMAD3_S425 and MAPK14_T180\n", + "i_search = 4\n", + "Looking for paths with length: 0 for node SMAD3_S425 and MAPK14_T180\n", + "i_search = 4\n", + "Looking for paths with length: 1 for node SMAD3_S425 and MAPK14_T180\n", + "i_search = 4\n", + "Looking for paths with length: 2 for node SMAD3_S425 and MAPK14_T180\n", + "i_search = 4\n", + "Looking for paths with length: 3 for node SMAD3_S425 and MAPK14_T180\n", + "i_search = 4\n", + "Looking for paths with length: 4 for node SMAD3_S425 and MAPK14_T180\n", + "looking for paths in the network with length: 0 for node SMAD3_S425 and MAPK14_Y182\n", + "looking for paths in the network with length: 1 for node SMAD3_S425 and MAPK14_Y182\n", + "looking for paths in the network with length: 2 for node SMAD3_S425 and MAPK14_Y182\n", + "looking for paths in the network with length: 3 for node SMAD3_S425 and MAPK14_Y182\n", + "looking for paths in the network with length: 4 for node SMAD3_S425 and MAPK14_Y182\n", + "looking for paths in the network with length: 5 for node SMAD3_S425 and MAPK14_Y182\n", + "looking for paths in the network with length: 6 for node SMAD3_S425 and MAPK14_Y182\n", + "looking for paths in the network with length: 7 for node SMAD3_S425 and MAPK14_Y182\n", + "looking for paths in the network with length: 8 for node SMAD3_S425 and MAPK14_Y182\n", + "looking for paths in the network with length: 9 for node SMAD3_S425 and MAPK14_Y182\n", + "looking for paths in the network with length: 10 for node SMAD3_S425 and MAPK14_Y182\n", + "i_search = 4\n", + "Looking for paths with length: 0 for node SMAD3_S425 and MAPK14_Y182\n", + "i_search = 4\n", + "Looking for paths with length: 1 for node SMAD3_S425 and MAPK14_Y182\n", + "i_search = 4\n", + "Looking for paths with length: 2 for node SMAD3_S425 and MAPK14_Y182\n", + "i_search = 4\n", + "Looking for paths with length: 3 for node SMAD3_S425 and MAPK14_Y182\n", + "i_search = 4\n", + "Looking for paths with length: 4 for node SMAD3_S425 and MAPK14_Y182\n", + "looking for paths in the network with length: 0 for node SMAD3_S425 and MAP2K1_S218\n", + "looking for paths in the network with length: 1 for node SMAD3_S425 and MAP2K1_S218\n", + "looking for paths in the network with length: 2 for node SMAD3_S425 and MAP2K1_S218\n", + "looking for paths in the network with length: 3 for node SMAD3_S425 and MAP2K1_S218\n", + "looking for paths in the network with length: 4 for node SMAD3_S425 and MAP2K1_S218\n", + "looking for paths in the network with length: 5 for node SMAD3_S425 and MAP2K1_S218\n", + "looking for paths in the network with length: 6 for node SMAD3_S425 and MAP2K1_S218\n", + "looking for paths in the network with length: 7 for node SMAD3_S425 and MAP2K1_S218\n", + "looking for paths in the network with length: 8 for node SMAD3_S425 and MAP2K1_S218\n", + "looking for paths in the network with length: 9 for node SMAD3_S425 and MAP2K1_S218\n", + "looking for paths in the network with length: 10 for node SMAD3_S425 and MAP2K1_S218\n", + "i_search = 4\n", + "Looking for paths with length: 0 for node SMAD3_S425 and MAP2K1_S218\n", + "i_search = 4\n", + "Looking for paths with length: 1 for node SMAD3_S425 and MAP2K1_S218\n", + "i_search = 4\n", + "Looking for paths with length: 2 for node SMAD3_S425 and MAP2K1_S218\n", + "i_search = 4\n", + "Looking for paths with length: 3 for node SMAD3_S425 and MAP2K1_S218\n", + "i_search = 4\n", + "Looking for paths with length: 4 for node SMAD3_S425 and MAP2K1_S218\n", + "looking for paths in the network with length: 0 for node SMAD3_S425 and MAP2K1_S222\n", + "looking for paths in the network with length: 1 for node SMAD3_S425 and MAP2K1_S222\n", + "looking for paths in the network with length: 2 for node SMAD3_S425 and MAP2K1_S222\n", + "looking for paths in the network with length: 3 for node SMAD3_S425 and MAP2K1_S222\n", + "looking for paths in the network with length: 4 for node SMAD3_S425 and MAP2K1_S222\n", + "looking for paths in the network with length: 5 for node SMAD3_S425 and MAP2K1_S222\n", + "looking for paths in the network with length: 6 for node SMAD3_S425 and MAP2K1_S222\n", + "looking for paths in the network with length: 7 for node SMAD3_S425 and MAP2K1_S222\n", + "looking for paths in the network with length: 8 for node SMAD3_S425 and MAP2K1_S222\n", + "looking for paths in the network with length: 9 for node SMAD3_S425 and MAP2K1_S222\n", + "looking for paths in the network with length: 10 for node SMAD3_S425 and MAP2K1_S222\n", + "i_search = 4\n", + "Looking for paths with length: 0 for node SMAD3_S425 and MAP2K1_S222\n", + "i_search = 4\n", + "Looking for paths with length: 1 for node SMAD3_S425 and MAP2K1_S222\n", + "i_search = 4\n", + "Looking for paths with length: 2 for node SMAD3_S425 and MAP2K1_S222\n", + "i_search = 4\n", + "Looking for paths with length: 3 for node SMAD3_S425 and MAP2K1_S222\n", + "i_search = 4\n", + "Looking for paths with length: 4 for node SMAD3_S425 and MAP2K1_S222\n", + "looking for paths in the network with length: 0 for node SMAD3_S425 and RPS6KA1_S380\n", + "looking for paths in the network with length: 1 for node SMAD3_S425 and RPS6KA1_S380\n", + "looking for paths in the network with length: 2 for node SMAD3_S425 and RPS6KA1_S380\n", + "looking for paths in the network with length: 3 for node SMAD3_S425 and RPS6KA1_S380\n", + "looking for paths in the network with length: 4 for node SMAD3_S425 and RPS6KA1_S380\n", + "looking for paths in the network with length: 5 for node SMAD3_S425 and RPS6KA1_S380\n", + "looking for paths in the network with length: 6 for node SMAD3_S425 and RPS6KA1_S380\n", + "looking for paths in the network with length: 7 for node SMAD3_S425 and RPS6KA1_S380\n", + "looking for paths in the network with length: 8 for node SMAD3_S425 and RPS6KA1_S380\n", + "looking for paths in the network with length: 9 for node SMAD3_S425 and RPS6KA1_S380\n", + "looking for paths in the network with length: 10 for node SMAD3_S425 and RPS6KA1_S380\n", + "i_search = 4\n", + "Looking for paths with length: 0 for node SMAD3_S425 and RPS6KA1_S380\n", + "i_search = 4\n", + "Looking for paths with length: 1 for node SMAD3_S425 and RPS6KA1_S380\n", + "i_search = 4\n", + "Looking for paths with length: 2 for node SMAD3_S425 and RPS6KA1_S380\n", + "i_search = 4\n", + "Looking for paths with length: 3 for node SMAD3_S425 and RPS6KA1_S380\n", + "i_search = 4\n", + "Looking for paths with length: 4 for node SMAD3_S425 and RPS6KA1_S380\n", + "looking for paths in the network with length: 0 for node SMAD3_S425 and CREB1_S133\n", + "looking for paths in the network with length: 1 for node SMAD3_S425 and CREB1_S133\n", + "looking for paths in the network with length: 2 for node SMAD3_S425 and CREB1_S133\n", + "looking for paths in the network with length: 3 for node SMAD3_S425 and CREB1_S133\n", + "looking for paths in the network with length: 4 for node SMAD3_S425 and CREB1_S133\n", + "looking for paths in the network with length: 5 for node SMAD3_S425 and CREB1_S133\n", + "looking for paths in the network with length: 6 for node SMAD3_S425 and CREB1_S133\n", + "looking for paths in the network with length: 7 for node SMAD3_S425 and CREB1_S133\n", + "looking for paths in the network with length: 8 for node SMAD3_S425 and CREB1_S133\n", + "looking for paths in the network with length: 9 for node SMAD3_S425 and CREB1_S133\n", + "looking for paths in the network with length: 10 for node SMAD3_S425 and CREB1_S133\n", + "i_search = 4\n", + "Looking for paths with length: 0 for node SMAD3_S425 and CREB1_S133\n", + "i_search = 4\n", + "Looking for paths with length: 1 for node SMAD3_S425 and CREB1_S133\n", + "i_search = 4\n", + "Looking for paths with length: 2 for node SMAD3_S425 and CREB1_S133\n", + "i_search = 4\n", + "Looking for paths with length: 3 for node SMAD3_S425 and CREB1_S133\n", + "i_search = 4\n", + "Looking for paths with length: 4 for node SMAD3_S425 and CREB1_S133\n", + "looking for paths in the network with length: 0 for node SMAD3_S425 and NFKBIA_S32\n", + "looking for paths in the network with length: 1 for node SMAD3_S425 and NFKBIA_S32\n", + "looking for paths in the network with length: 2 for node SMAD3_S425 and NFKBIA_S32\n", + "looking for paths in the network with length: 3 for node SMAD3_S425 and NFKBIA_S32\n", + "looking for paths in the network with length: 4 for node SMAD3_S425 and NFKBIA_S32\n", + "looking for paths in the network with length: 5 for node SMAD3_S425 and NFKBIA_S32\n", + "looking for paths in the network with length: 6 for node SMAD3_S425 and NFKBIA_S32\n", + "looking for paths in the network with length: 7 for node SMAD3_S425 and NFKBIA_S32\n", + "looking for paths in the network with length: 8 for node SMAD3_S425 and NFKBIA_S32\n", + "looking for paths in the network with length: 9 for node SMAD3_S425 and NFKBIA_S32\n", + "looking for paths in the network with length: 10 for node SMAD3_S425 and NFKBIA_S32\n", + "i_search = 4\n", + "Looking for paths with length: 0 for node SMAD3_S425 and NFKBIA_S32\n", + "i_search = 4\n", + "Looking for paths with length: 1 for node SMAD3_S425 and NFKBIA_S32\n", + "i_search = 4\n", + "Looking for paths with length: 2 for node SMAD3_S425 and NFKBIA_S32\n", + "i_search = 4\n", + "Looking for paths with length: 3 for node SMAD3_S425 and NFKBIA_S32\n", + "i_search = 4\n", + "Looking for paths with length: 4 for node SMAD3_S425 and NFKBIA_S32\n", + "looking for paths in the network with length: 0 for node SMAD3_S425 and NFKBIA_S36\n", + "looking for paths in the network with length: 1 for node SMAD3_S425 and NFKBIA_S36\n", + "looking for paths in the network with length: 2 for node SMAD3_S425 and NFKBIA_S36\n", + "looking for paths in the network with length: 3 for node SMAD3_S425 and NFKBIA_S36\n", + "looking for paths in the network with length: 4 for node SMAD3_S425 and NFKBIA_S36\n", + "looking for paths in the network with length: 5 for node SMAD3_S425 and NFKBIA_S36\n", + "looking for paths in the network with length: 6 for node SMAD3_S425 and NFKBIA_S36\n", + "looking for paths in the network with length: 7 for node SMAD3_S425 and NFKBIA_S36\n", + "looking for paths in the network with length: 8 for node SMAD3_S425 and NFKBIA_S36\n", + "looking for paths in the network with length: 9 for node SMAD3_S425 and NFKBIA_S36\n", + "looking for paths in the network with length: 10 for node SMAD3_S425 and NFKBIA_S36\n", + "i_search = 4\n", + "Looking for paths with length: 0 for node SMAD3_S425 and NFKBIA_S36\n", + "i_search = 4\n", + "Looking for paths with length: 1 for node SMAD3_S425 and NFKBIA_S36\n", + "i_search = 4\n", + "Looking for paths with length: 2 for node SMAD3_S425 and NFKBIA_S36\n", + "i_search = 4\n", + "Looking for paths with length: 3 for node SMAD3_S425 and NFKBIA_S36\n", + "i_search = 4\n", + "Looking for paths with length: 4 for node SMAD3_S425 and NFKBIA_S36\n", + "looking for paths in the network with length: 0 for node SMAD3_S425 and MTOR_S2448\n", + "looking for paths in the network with length: 1 for node SMAD3_S425 and MTOR_S2448\n", + "looking for paths in the network with length: 2 for node SMAD3_S425 and MTOR_S2448\n", + "looking for paths in the network with length: 3 for node SMAD3_S425 and MTOR_S2448\n", + "looking for paths in the network with length: 4 for node SMAD3_S425 and MTOR_S2448\n", + "looking for paths in the network with length: 5 for node SMAD3_S425 and MTOR_S2448\n", + "looking for paths in the network with length: 6 for node SMAD3_S425 and MTOR_S2448\n", + "looking for paths in the network with length: 7 for node SMAD3_S425 and MTOR_S2448\n", + "looking for paths in the network with length: 8 for node SMAD3_S425 and MTOR_S2448\n", + "looking for paths in the network with length: 9 for node SMAD3_S425 and MTOR_S2448\n", + "looking for paths in the network with length: 10 for node SMAD3_S425 and MTOR_S2448\n", + "i_search = 4\n", + "Looking for paths with length: 0 for node SMAD3_S425 and MTOR_S2448\n", + "i_search = 4\n", + "Looking for paths with length: 1 for node SMAD3_S425 and MTOR_S2448\n", + "i_search = 4\n", + "Looking for paths with length: 2 for node SMAD3_S425 and MTOR_S2448\n", + "i_search = 4\n", + "Looking for paths with length: 3 for node SMAD3_S425 and MTOR_S2448\n", + "i_search = 4\n", + "Looking for paths with length: 4 for node SMAD3_S425 and MTOR_S2448\n", + "looking for paths in the network with length: 0 for node SMAD3_S425 and JUN_S63\n", + "looking for paths in the network with length: 1 for node SMAD3_S425 and JUN_S63\n", + "looking for paths in the network with length: 2 for node SMAD3_S425 and JUN_S63\n", + "looking for paths in the network with length: 3 for node SMAD3_S425 and JUN_S63\n", + "looking for paths in the network with length: 4 for node SMAD3_S425 and JUN_S63\n", + "looking for paths in the network with length: 5 for node SMAD3_S425 and JUN_S63\n", + "looking for paths in the network with length: 6 for node SMAD3_S425 and JUN_S63\n", + "looking for paths in the network with length: 7 for node SMAD3_S425 and JUN_S63\n", + "looking for paths in the network with length: 8 for node SMAD3_S425 and JUN_S63\n", + "looking for paths in the network with length: 9 for node SMAD3_S425 and JUN_S63\n", + "looking for paths in the network with length: 10 for node SMAD3_S425 and JUN_S63\n", + "i_search = 4\n", + "Looking for paths with length: 0 for node SMAD3_S425 and JUN_S63\n", + "i_search = 4\n", + "Looking for paths with length: 1 for node SMAD3_S425 and JUN_S63\n", + "i_search = 4\n", + "Looking for paths with length: 2 for node SMAD3_S425 and JUN_S63\n", + "i_search = 4\n", + "Looking for paths with length: 3 for node SMAD3_S425 and JUN_S63\n", + "i_search = 4\n", + "Looking for paths with length: 4 for node SMAD3_S425 and JUN_S63\n", + "looking for paths in the network with length: 0 for node SMAD3_S425 and EGFR_Y1068\n", + "looking for paths in the network with length: 1 for node SMAD3_S425 and EGFR_Y1068\n", + "looking for paths in the network with length: 2 for node SMAD3_S425 and EGFR_Y1068\n", + "looking for paths in the network with length: 3 for node SMAD3_S425 and EGFR_Y1068\n", + "looking for paths in the network with length: 4 for node SMAD3_S425 and EGFR_Y1068\n", + "looking for paths in the network with length: 5 for node SMAD3_S425 and EGFR_Y1068\n", + "looking for paths in the network with length: 6 for node SMAD3_S425 and EGFR_Y1068\n", + "looking for paths in the network with length: 7 for node SMAD3_S425 and EGFR_Y1068\n", + "looking for paths in the network with length: 8 for node SMAD3_S425 and EGFR_Y1068\n", + "looking for paths in the network with length: 9 for node SMAD3_S425 and EGFR_Y1068\n", + "looking for paths in the network with length: 10 for node SMAD3_S425 and EGFR_Y1068\n", + "i_search = 4\n", + "Looking for paths with length: 0 for node SMAD3_S425 and EGFR_Y1068\n", + "i_search = 4\n", + "Looking for paths with length: 1 for node SMAD3_S425 and EGFR_Y1068\n", + "i_search = 4\n", + "Looking for paths with length: 2 for node SMAD3_S425 and EGFR_Y1068\n", + "i_search = 4\n", + "Looking for paths with length: 3 for node SMAD3_S425 and EGFR_Y1068\n", + "i_search = 4\n", + "Looking for paths with length: 4 for node SMAD3_S425 and EGFR_Y1068\n", + "looking for paths in the network with length: 0 for node SMAD3_S425 and MAPK3_T202\n", + "looking for paths in the network with length: 1 for node SMAD3_S425 and MAPK3_T202\n", + "looking for paths in the network with length: 2 for node SMAD3_S425 and MAPK3_T202\n", + "looking for paths in the network with length: 3 for node SMAD3_S425 and MAPK3_T202\n", + "looking for paths in the network with length: 4 for node SMAD3_S425 and MAPK3_T202\n", + "looking for paths in the network with length: 5 for node SMAD3_S425 and MAPK3_T202\n", + "looking for paths in the network with length: 6 for node SMAD3_S425 and MAPK3_T202\n", + "looking for paths in the network with length: 7 for node SMAD3_S425 and MAPK3_T202\n", + "looking for paths in the network with length: 8 for node SMAD3_S425 and MAPK3_T202\n", + "looking for paths in the network with length: 9 for node SMAD3_S425 and MAPK3_T202\n", + "looking for paths in the network with length: 10 for node SMAD3_S425 and MAPK3_T202\n", + "i_search = 4\n", + "Looking for paths with length: 0 for node SMAD3_S425 and MAPK3_T202\n", + "i_search = 4\n", + "Looking for paths with length: 1 for node SMAD3_S425 and MAPK3_T202\n", + "i_search = 4\n", + "Looking for paths with length: 2 for node SMAD3_S425 and MAPK3_T202\n", + "i_search = 4\n", + "Looking for paths with length: 3 for node SMAD3_S425 and MAPK3_T202\n", + "i_search = 4\n", + "Looking for paths with length: 4 for node SMAD3_S425 and MAPK3_T202\n", + "looking for paths in the network with length: 0 for node SMAD3_S425 and MAPK3_Y204\n", + "looking for paths in the network with length: 1 for node SMAD3_S425 and MAPK3_Y204\n", + "looking for paths in the network with length: 2 for node SMAD3_S425 and MAPK3_Y204\n", + "looking for paths in the network with length: 3 for node SMAD3_S425 and MAPK3_Y204\n", + "looking for paths in the network with length: 4 for node SMAD3_S425 and MAPK3_Y204\n", + "looking for paths in the network with length: 5 for node SMAD3_S425 and MAPK3_Y204\n", + "looking for paths in the network with length: 6 for node SMAD3_S425 and MAPK3_Y204\n", + "looking for paths in the network with length: 7 for node SMAD3_S425 and MAPK3_Y204\n", + "looking for paths in the network with length: 8 for node SMAD3_S425 and MAPK3_Y204\n", + "looking for paths in the network with length: 9 for node SMAD3_S425 and MAPK3_Y204\n", + "looking for paths in the network with length: 10 for node SMAD3_S425 and MAPK3_Y204\n", + "i_search = 4\n", + "Looking for paths with length: 0 for node SMAD3_S425 and MAPK3_Y204\n", + "i_search = 4\n", + "Looking for paths with length: 1 for node SMAD3_S425 and MAPK3_Y204\n", + "i_search = 4\n", + "Looking for paths with length: 2 for node SMAD3_S425 and MAPK3_Y204\n", + "i_search = 4\n", + "Looking for paths with length: 3 for node SMAD3_S425 and MAPK3_Y204\n", + "i_search = 4\n", + "Looking for paths with length: 4 for node SMAD3_S425 and MAPK3_Y204\n", + "looking for paths in the network with length: 0 for node SMAD3_S425 and PTPN11_Y542\n", + "looking for paths in the network with length: 1 for node SMAD3_S425 and PTPN11_Y542\n", + "looking for paths in the network with length: 2 for node SMAD3_S425 and PTPN11_Y542\n", + "looking for paths in the network with length: 3 for node SMAD3_S425 and PTPN11_Y542\n", + "looking for paths in the network with length: 4 for node SMAD3_S425 and PTPN11_Y542\n", + "looking for paths in the network with length: 5 for node SMAD3_S425 and PTPN11_Y542\n", + "looking for paths in the network with length: 6 for node SMAD3_S425 and PTPN11_Y542\n", + "looking for paths in the network with length: 7 for node SMAD3_S425 and PTPN11_Y542\n", + "looking for paths in the network with length: 8 for node SMAD3_S425 and PTPN11_Y542\n", + "looking for paths in the network with length: 9 for node SMAD3_S425 and PTPN11_Y542\n", + "looking for paths in the network with length: 10 for node SMAD3_S425 and PTPN11_Y542\n", + "i_search = 4\n", + "Looking for paths with length: 0 for node SMAD3_S425 and PTPN11_Y542\n", + "i_search = 4\n", + "Looking for paths with length: 1 for node SMAD3_S425 and PTPN11_Y542\n", + "i_search = 4\n", + "Looking for paths with length: 2 for node SMAD3_S425 and PTPN11_Y542\n", + "i_search = 4\n", + "Looking for paths with length: 3 for node SMAD3_S425 and PTPN11_Y542\n", + "i_search = 4\n", + "Looking for paths with length: 4 for node SMAD3_S425 and PTPN11_Y542\n", + "looking for paths in the network with length: 0 for node SMAD3_S425 and STAT3_Y705\n", + "looking for paths in the network with length: 1 for node SMAD3_S425 and STAT3_Y705\n", + "looking for paths in the network with length: 2 for node SMAD3_S425 and STAT3_Y705\n", + "looking for paths in the network with length: 3 for node SMAD3_S425 and STAT3_Y705\n", + "looking for paths in the network with length: 4 for node SMAD3_S425 and STAT3_Y705\n", + "looking for paths in the network with length: 5 for node SMAD3_S425 and STAT3_Y705\n", + "looking for paths in the network with length: 6 for node SMAD3_S425 and STAT3_Y705\n", + "looking for paths in the network with length: 7 for node SMAD3_S425 and STAT3_Y705\n", + "looking for paths in the network with length: 8 for node SMAD3_S425 and STAT3_Y705\n", + "looking for paths in the network with length: 9 for node SMAD3_S425 and STAT3_Y705\n", + "looking for paths in the network with length: 10 for node SMAD3_S425 and STAT3_Y705\n", + "i_search = 4\n", + "Looking for paths with length: 0 for node SMAD3_S425 and STAT3_Y705\n", + "i_search = 4\n", + "Looking for paths with length: 1 for node SMAD3_S425 and STAT3_Y705\n", + "i_search = 4\n", + "Looking for paths with length: 2 for node SMAD3_S425 and STAT3_Y705\n", + "i_search = 4\n", + "Looking for paths with length: 3 for node SMAD3_S425 and STAT3_Y705\n", + "i_search = 4\n", + "Looking for paths with length: 4 for node SMAD3_S425 and STAT3_Y705\n", + "looking for paths in the network with length: 0 for node SMAD3_S425 and CHEK2_T68\n", + "looking for paths in the network with length: 1 for node SMAD3_S425 and CHEK2_T68\n", + "looking for paths in the network with length: 2 for node SMAD3_S425 and CHEK2_T68\n", + "looking for paths in the network with length: 3 for node SMAD3_S425 and CHEK2_T68\n", + "looking for paths in the network with length: 4 for node SMAD3_S425 and CHEK2_T68\n", + "looking for paths in the network with length: 5 for node SMAD3_S425 and CHEK2_T68\n", + "looking for paths in the network with length: 6 for node SMAD3_S425 and CHEK2_T68\n", + "looking for paths in the network with length: 7 for node SMAD3_S425 and CHEK2_T68\n", + "looking for paths in the network with length: 8 for node SMAD3_S425 and CHEK2_T68\n", + "looking for paths in the network with length: 9 for node SMAD3_S425 and CHEK2_T68\n", + "looking for paths in the network with length: 10 for node SMAD3_S425 and CHEK2_T68\n", + "i_search = 4\n", + "Looking for paths with length: 0 for node SMAD3_S425 and CHEK2_T68\n", + "i_search = 4\n", + "Looking for paths with length: 1 for node SMAD3_S425 and CHEK2_T68\n", + "i_search = 4\n", + "Looking for paths with length: 2 for node SMAD3_S425 and CHEK2_T68\n", + "i_search = 4\n", + "Looking for paths with length: 3 for node SMAD3_S425 and CHEK2_T68\n", + "i_search = 4\n", + "Looking for paths with length: 4 for node SMAD3_S425 and CHEK2_T68\n", + "looking for paths in the network with length: 0 for node SMAD3_S425 and RELA_S536\n", + "looking for paths in the network with length: 1 for node SMAD3_S425 and RELA_S536\n", + "looking for paths in the network with length: 2 for node SMAD3_S425 and RELA_S536\n", + "looking for paths in the network with length: 3 for node SMAD3_S425 and RELA_S536\n", + "looking for paths in the network with length: 4 for node SMAD3_S425 and RELA_S536\n", + "looking for paths in the network with length: 5 for node SMAD3_S425 and RELA_S536\n", + "looking for paths in the network with length: 6 for node SMAD3_S425 and RELA_S536\n", + "looking for paths in the network with length: 7 for node SMAD3_S425 and RELA_S536\n", + "looking for paths in the network with length: 8 for node SMAD3_S425 and RELA_S536\n", + "looking for paths in the network with length: 9 for node SMAD3_S425 and RELA_S536\n", + "looking for paths in the network with length: 10 for node SMAD3_S425 and RELA_S536\n", + "i_search = 4\n", + "Looking for paths with length: 0 for node SMAD3_S425 and RELA_S536\n", + "i_search = 4\n", + "Looking for paths with length: 1 for node SMAD3_S425 and RELA_S536\n", + "i_search = 4\n", + "Looking for paths with length: 2 for node SMAD3_S425 and RELA_S536\n", + "i_search = 4\n", + "Looking for paths with length: 3 for node SMAD3_S425 and RELA_S536\n", + "i_search = 4\n", + "Looking for paths with length: 4 for node SMAD3_S425 and RELA_S536\n", + "looking for paths in the network with length: 0 for node SMAD3_S425 and MARCKS_S170\n", + "looking for paths in the network with length: 1 for node SMAD3_S425 and MARCKS_S170\n", + "looking for paths in the network with length: 2 for node SMAD3_S425 and MARCKS_S170\n", + "looking for paths in the network with length: 3 for node SMAD3_S425 and MARCKS_S170\n", + "looking for paths in the network with length: 4 for node SMAD3_S425 and MARCKS_S170\n", + "looking for paths in the network with length: 5 for node SMAD3_S425 and MARCKS_S170\n", + "looking for paths in the network with length: 6 for node SMAD3_S425 and MARCKS_S170\n", + "looking for paths in the network with length: 7 for node SMAD3_S425 and MARCKS_S170\n", + "looking for paths in the network with length: 8 for node SMAD3_S425 and MARCKS_S170\n", + "looking for paths in the network with length: 9 for node SMAD3_S425 and MARCKS_S170\n", + "looking for paths in the network with length: 10 for node SMAD3_S425 and MARCKS_S170\n", + "i_search = 4\n", + "Looking for paths with length: 0 for node SMAD3_S425 and MARCKS_S170\n", + "i_search = 4\n", + "Looking for paths with length: 1 for node SMAD3_S425 and MARCKS_S170\n", + "i_search = 4\n", + "Looking for paths with length: 2 for node SMAD3_S425 and MARCKS_S170\n", + "i_search = 4\n", + "Looking for paths with length: 3 for node SMAD3_S425 and MARCKS_S170\n", + "i_search = 4\n", + "Looking for paths with length: 4 for node SMAD3_S425 and MARCKS_S170\n", + "looking for paths in the network with length: 0 for node SMAD3_S425 and SMAD3\n", + "looking for paths in the network with length: 1 for node SMAD3_S425 and SMAD3\n", + "looking for paths in the network with length: 2 for node SMAD3_S425 and SMAD3\n", + "looking for paths in the network with length: 3 for node SMAD3_S425 and SMAD3\n", + "looking for paths in the network with length: 4 for node SMAD3_S425 and SMAD3\n", + "looking for paths in the network with length: 5 for node SMAD3_S425 and SMAD3\n", + "looking for paths in the network with length: 6 for node SMAD3_S425 and SMAD3\n", + "looking for paths in the network with length: 7 for node SMAD3_S425 and SMAD3\n", + "looking for paths in the network with length: 8 for node SMAD3_S425 and SMAD3\n", + "looking for paths in the network with length: 9 for node SMAD3_S425 and SMAD3\n", + "looking for paths in the network with length: 10 for node SMAD3_S425 and SMAD3\n", + "i_search = 4\n", + "Looking for paths with length: 0 for node SMAD3_S425 and SMAD3\n", + "i_search = 4\n", + "Looking for paths with length: 1 for node SMAD3_S425 and SMAD3\n", + "i_search = 4\n", + "Looking for paths with length: 2 for node SMAD3_S425 and SMAD3\n", + "i_search = 4\n", + "Looking for paths with length: 3 for node SMAD3_S425 and SMAD3\n", + "i_search = 4\n", + "Looking for paths with length: 4 for node SMAD3_S425 and SMAD3\n", + "looking for paths in the network with length: 0 for node SMAD3_S425 and TP53\n", + "looking for paths in the network with length: 1 for node SMAD3_S425 and TP53\n", + "looking for paths in the network with length: 2 for node SMAD3_S425 and TP53\n", + "looking for paths in the network with length: 3 for node SMAD3_S425 and TP53\n", + "looking for paths in the network with length: 4 for node SMAD3_S425 and TP53\n", + "looking for paths in the network with length: 5 for node SMAD3_S425 and TP53\n", + "looking for paths in the network with length: 6 for node SMAD3_S425 and TP53\n", + "looking for paths in the network with length: 7 for node SMAD3_S425 and TP53\n", + "looking for paths in the network with length: 8 for node SMAD3_S425 and TP53\n", + "looking for paths in the network with length: 9 for node SMAD3_S425 and TP53\n", + "looking for paths in the network with length: 10 for node SMAD3_S425 and TP53\n", + "i_search = 4\n", + "Looking for paths with length: 0 for node SMAD3_S425 and TP53\n", + "i_search = 4\n", + "Looking for paths with length: 1 for node SMAD3_S425 and TP53\n", + "i_search = 4\n", + "Looking for paths with length: 2 for node SMAD3_S425 and TP53\n", + "i_search = 4\n", + "Looking for paths with length: 3 for node SMAD3_S425 and TP53\n", + "i_search = 4\n", + "Looking for paths with length: 4 for node SMAD3_S425 and TP53\n", + "looking for paths in the network with length: 0 for node SMAD3_S425 and AKT1S1\n", + "looking for paths in the network with length: 1 for node SMAD3_S425 and AKT1S1\n", + "looking for paths in the network with length: 2 for node SMAD3_S425 and AKT1S1\n", + "looking for paths in the network with length: 3 for node SMAD3_S425 and AKT1S1\n", + "looking for paths in the network with length: 4 for node SMAD3_S425 and AKT1S1\n", + "looking for paths in the network with length: 5 for node SMAD3_S425 and AKT1S1\n", + "looking for paths in the network with length: 6 for node SMAD3_S425 and AKT1S1\n", + "looking for paths in the network with length: 7 for node SMAD3_S425 and AKT1S1\n", + "looking for paths in the network with length: 8 for node SMAD3_S425 and AKT1S1\n", + "looking for paths in the network with length: 9 for node SMAD3_S425 and AKT1S1\n", + "looking for paths in the network with length: 10 for node SMAD3_S425 and AKT1S1\n", + "i_search = 4\n", + "Looking for paths with length: 0 for node SMAD3_S425 and AKT1S1\n", + "i_search = 4\n", + "Looking for paths with length: 1 for node SMAD3_S425 and AKT1S1\n", + "i_search = 4\n", + "Looking for paths with length: 2 for node SMAD3_S425 and AKT1S1\n", + "i_search = 4\n", + "Looking for paths with length: 3 for node SMAD3_S425 and AKT1S1\n", + "i_search = 4\n", + "Looking for paths with length: 4 for node SMAD3_S425 and AKT1S1\n", + "looking for paths in the network with length: 0 for node SMAD3_S425 and GSK3B\n", + "looking for paths in the network with length: 1 for node SMAD3_S425 and GSK3B\n", + "looking for paths in the network with length: 2 for node SMAD3_S425 and GSK3B\n", + "looking for paths in the network with length: 3 for node SMAD3_S425 and GSK3B\n", + "looking for paths in the network with length: 4 for node SMAD3_S425 and GSK3B\n", + "looking for paths in the network with length: 5 for node SMAD3_S425 and GSK3B\n", + "looking for paths in the network with length: 6 for node SMAD3_S425 and GSK3B\n", + "looking for paths in the network with length: 7 for node SMAD3_S425 and GSK3B\n", + "looking for paths in the network with length: 8 for node SMAD3_S425 and GSK3B\n", + "looking for paths in the network with length: 9 for node SMAD3_S425 and GSK3B\n", + "looking for paths in the network with length: 10 for node SMAD3_S425 and GSK3B\n", + "i_search = 4\n", + "Looking for paths with length: 0 for node SMAD3_S425 and GSK3B\n", + "i_search = 4\n", + "Looking for paths with length: 1 for node SMAD3_S425 and GSK3B\n", + "i_search = 4\n", + "Looking for paths with length: 2 for node SMAD3_S425 and GSK3B\n", + "i_search = 4\n", + "Looking for paths with length: 3 for node SMAD3_S425 and GSK3B\n", + "i_search = 4\n", + "Looking for paths with length: 4 for node SMAD3_S425 and GSK3B\n", + "looking for paths in the network with length: 0 for node SMAD3_S425 and AKT1\n", + "looking for paths in the network with length: 1 for node SMAD3_S425 and AKT1\n", + "looking for paths in the network with length: 2 for node SMAD3_S425 and AKT1\n", + "looking for paths in the network with length: 3 for node SMAD3_S425 and AKT1\n", + "looking for paths in the network with length: 4 for node SMAD3_S425 and AKT1\n", + "looking for paths in the network with length: 5 for node SMAD3_S425 and AKT1\n", + "looking for paths in the network with length: 6 for node SMAD3_S425 and AKT1\n", + "looking for paths in the network with length: 7 for node SMAD3_S425 and AKT1\n", + "looking for paths in the network with length: 8 for node SMAD3_S425 and AKT1\n", + "looking for paths in the network with length: 9 for node SMAD3_S425 and AKT1\n", + "looking for paths in the network with length: 10 for node SMAD3_S425 and AKT1\n", + "i_search = 4\n", + "Looking for paths with length: 0 for node SMAD3_S425 and AKT1\n", + "i_search = 4\n", + "Looking for paths with length: 1 for node SMAD3_S425 and AKT1\n", + "i_search = 4\n", + "Looking for paths with length: 2 for node SMAD3_S425 and AKT1\n", + "i_search = 4\n", + "Looking for paths with length: 3 for node SMAD3_S425 and AKT1\n", + "i_search = 4\n", + "Looking for paths with length: 4 for node SMAD3_S425 and AKT1\n", + "looking for paths in the network with length: 0 for node SMAD3_S425 and HSPB1\n", + "looking for paths in the network with length: 1 for node SMAD3_S425 and HSPB1\n", + "looking for paths in the network with length: 2 for node SMAD3_S425 and HSPB1\n", + "looking for paths in the network with length: 3 for node SMAD3_S425 and HSPB1\n", + "looking for paths in the network with length: 4 for node SMAD3_S425 and HSPB1\n", + "looking for paths in the network with length: 5 for node SMAD3_S425 and HSPB1\n", + "looking for paths in the network with length: 6 for node SMAD3_S425 and HSPB1\n", + "looking for paths in the network with length: 7 for node SMAD3_S425 and HSPB1\n", + "looking for paths in the network with length: 8 for node SMAD3_S425 and HSPB1\n", + "looking for paths in the network with length: 9 for node SMAD3_S425 and HSPB1\n", + "looking for paths in the network with length: 10 for node SMAD3_S425 and HSPB1\n", + "i_search = 4\n", + "Looking for paths with length: 0 for node SMAD3_S425 and HSPB1\n", + "i_search = 4\n", + "Looking for paths with length: 1 for node SMAD3_S425 and HSPB1\n", + "i_search = 4\n", + "Looking for paths with length: 2 for node SMAD3_S425 and HSPB1\n", + "i_search = 4\n", + "Looking for paths with length: 3 for node SMAD3_S425 and HSPB1\n", + "i_search = 4\n", + "Looking for paths with length: 4 for node SMAD3_S425 and HSPB1\n", + "looking for paths in the network with length: 0 for node SMAD3_S425 and MAPK14\n", + "looking for paths in the network with length: 1 for node SMAD3_S425 and MAPK14\n", + "looking for paths in the network with length: 2 for node SMAD3_S425 and MAPK14\n", + "looking for paths in the network with length: 3 for node SMAD3_S425 and MAPK14\n", + "looking for paths in the network with length: 4 for node SMAD3_S425 and MAPK14\n", + "looking for paths in the network with length: 5 for node SMAD3_S425 and MAPK14\n", + "looking for paths in the network with length: 6 for node SMAD3_S425 and MAPK14\n", + "looking for paths in the network with length: 7 for node SMAD3_S425 and MAPK14\n", + "looking for paths in the network with length: 8 for node SMAD3_S425 and MAPK14\n", + "looking for paths in the network with length: 9 for node SMAD3_S425 and MAPK14\n", + "looking for paths in the network with length: 10 for node SMAD3_S425 and MAPK14\n", + "i_search = 4\n", + "Looking for paths with length: 0 for node SMAD3_S425 and MAPK14\n", + "i_search = 4\n", + "Looking for paths with length: 1 for node SMAD3_S425 and MAPK14\n", + "i_search = 4\n", + "Looking for paths with length: 2 for node SMAD3_S425 and MAPK14\n", + "i_search = 4\n", + "Looking for paths with length: 3 for node SMAD3_S425 and MAPK14\n", + "i_search = 4\n", + "Looking for paths with length: 4 for node SMAD3_S425 and MAPK14\n", + "looking for paths in the network with length: 0 for node SMAD3_S425 and MAP2K1\n", + "looking for paths in the network with length: 1 for node SMAD3_S425 and MAP2K1\n", + "looking for paths in the network with length: 2 for node SMAD3_S425 and MAP2K1\n", + "looking for paths in the network with length: 3 for node SMAD3_S425 and MAP2K1\n", + "looking for paths in the network with length: 4 for node SMAD3_S425 and MAP2K1\n", + "looking for paths in the network with length: 5 for node SMAD3_S425 and MAP2K1\n", + "looking for paths in the network with length: 6 for node SMAD3_S425 and MAP2K1\n", + "looking for paths in the network with length: 7 for node SMAD3_S425 and MAP2K1\n", + "looking for paths in the network with length: 8 for node SMAD3_S425 and MAP2K1\n", + "looking for paths in the network with length: 9 for node SMAD3_S425 and MAP2K1\n", + "looking for paths in the network with length: 10 for node SMAD3_S425 and MAP2K1\n", + "i_search = 4\n", + "Looking for paths with length: 0 for node SMAD3_S425 and MAP2K1\n", + "i_search = 4\n", + "Looking for paths with length: 1 for node SMAD3_S425 and MAP2K1\n", + "i_search = 4\n", + "Looking for paths with length: 2 for node SMAD3_S425 and MAP2K1\n", + "i_search = 4\n", + "Looking for paths with length: 3 for node SMAD3_S425 and MAP2K1\n", + "i_search = 4\n", + "Looking for paths with length: 4 for node SMAD3_S425 and MAP2K1\n", + "looking for paths in the network with length: 0 for node SMAD3_S425 and RPS6KA1\n", + "looking for paths in the network with length: 1 for node SMAD3_S425 and RPS6KA1\n", + "looking for paths in the network with length: 2 for node SMAD3_S425 and RPS6KA1\n", + "looking for paths in the network with length: 3 for node SMAD3_S425 and RPS6KA1\n", + "looking for paths in the network with length: 4 for node SMAD3_S425 and RPS6KA1\n", + "looking for paths in the network with length: 5 for node SMAD3_S425 and RPS6KA1\n", + "looking for paths in the network with length: 6 for node SMAD3_S425 and RPS6KA1\n", + "looking for paths in the network with length: 7 for node SMAD3_S425 and RPS6KA1\n", + "looking for paths in the network with length: 8 for node SMAD3_S425 and RPS6KA1\n", + "looking for paths in the network with length: 9 for node SMAD3_S425 and RPS6KA1\n", + "looking for paths in the network with length: 10 for node SMAD3_S425 and RPS6KA1\n", + "i_search = 4\n", + "Looking for paths with length: 0 for node SMAD3_S425 and RPS6KA1\n", + "i_search = 4\n", + "Looking for paths with length: 1 for node SMAD3_S425 and RPS6KA1\n", + "i_search = 4\n", + "Looking for paths with length: 2 for node SMAD3_S425 and RPS6KA1\n", + "i_search = 4\n", + "Looking for paths with length: 3 for node SMAD3_S425 and RPS6KA1\n", + "i_search = 4\n", + "Looking for paths with length: 4 for node SMAD3_S425 and RPS6KA1\n", + "looking for paths in the network with length: 0 for node SMAD3_S425 and CREB1\n", + "looking for paths in the network with length: 1 for node SMAD3_S425 and CREB1\n", + "looking for paths in the network with length: 2 for node SMAD3_S425 and CREB1\n", + "looking for paths in the network with length: 3 for node SMAD3_S425 and CREB1\n", + "looking for paths in the network with length: 4 for node SMAD3_S425 and CREB1\n", + "looking for paths in the network with length: 5 for node SMAD3_S425 and CREB1\n", + "looking for paths in the network with length: 6 for node SMAD3_S425 and CREB1\n", + "looking for paths in the network with length: 7 for node SMAD3_S425 and CREB1\n", + "looking for paths in the network with length: 8 for node SMAD3_S425 and CREB1\n", + "looking for paths in the network with length: 9 for node SMAD3_S425 and CREB1\n", + "looking for paths in the network with length: 10 for node SMAD3_S425 and CREB1\n", + "i_search = 4\n", + "Looking for paths with length: 0 for node SMAD3_S425 and CREB1\n", + "i_search = 4\n", + "Looking for paths with length: 1 for node SMAD3_S425 and CREB1\n", + "i_search = 4\n", + "Looking for paths with length: 2 for node SMAD3_S425 and CREB1\n", + "i_search = 4\n", + "Looking for paths with length: 3 for node SMAD3_S425 and CREB1\n", + "i_search = 4\n", + "Looking for paths with length: 4 for node SMAD3_S425 and CREB1\n", + "looking for paths in the network with length: 0 for node SMAD3_S425 and NFKBIA\n", + "looking for paths in the network with length: 1 for node SMAD3_S425 and NFKBIA\n", + "looking for paths in the network with length: 2 for node SMAD3_S425 and NFKBIA\n", + "looking for paths in the network with length: 3 for node SMAD3_S425 and NFKBIA\n", + "looking for paths in the network with length: 4 for node SMAD3_S425 and NFKBIA\n", + "looking for paths in the network with length: 5 for node SMAD3_S425 and NFKBIA\n", + "looking for paths in the network with length: 6 for node SMAD3_S425 and NFKBIA\n", + "looking for paths in the network with length: 7 for node SMAD3_S425 and NFKBIA\n", + "looking for paths in the network with length: 8 for node SMAD3_S425 and NFKBIA\n", + "looking for paths in the network with length: 9 for node SMAD3_S425 and NFKBIA\n", + "looking for paths in the network with length: 10 for node SMAD3_S425 and NFKBIA\n", + "i_search = 4\n", + "Looking for paths with length: 0 for node SMAD3_S425 and NFKBIA\n", + "i_search = 4\n", + "Looking for paths with length: 1 for node SMAD3_S425 and NFKBIA\n", + "i_search = 4\n", + "Looking for paths with length: 2 for node SMAD3_S425 and NFKBIA\n", + "i_search = 4\n", + "Looking for paths with length: 3 for node SMAD3_S425 and NFKBIA\n", + "i_search = 4\n", + "Looking for paths with length: 4 for node SMAD3_S425 and NFKBIA\n", + "looking for paths in the network with length: 0 for node SMAD3_S425 and MTOR\n", + "looking for paths in the network with length: 1 for node SMAD3_S425 and MTOR\n", + "looking for paths in the network with length: 2 for node SMAD3_S425 and MTOR\n", + "looking for paths in the network with length: 3 for node SMAD3_S425 and MTOR\n", + "looking for paths in the network with length: 4 for node SMAD3_S425 and MTOR\n", + "looking for paths in the network with length: 5 for node SMAD3_S425 and MTOR\n", + "looking for paths in the network with length: 6 for node SMAD3_S425 and MTOR\n", + "looking for paths in the network with length: 7 for node SMAD3_S425 and MTOR\n", + "looking for paths in the network with length: 8 for node SMAD3_S425 and MTOR\n", + "looking for paths in the network with length: 9 for node SMAD3_S425 and MTOR\n", + "looking for paths in the network with length: 10 for node SMAD3_S425 and MTOR\n", + "i_search = 4\n", + "Looking for paths with length: 0 for node SMAD3_S425 and MTOR\n", + "i_search = 4\n", + "Looking for paths with length: 1 for node SMAD3_S425 and MTOR\n", + "i_search = 4\n", + "Looking for paths with length: 2 for node SMAD3_S425 and MTOR\n", + "i_search = 4\n", + "Looking for paths with length: 3 for node SMAD3_S425 and MTOR\n", + "i_search = 4\n", + "Looking for paths with length: 4 for node SMAD3_S425 and MTOR\n", + "looking for paths in the network with length: 0 for node SMAD3_S425 and JUN\n", + "looking for paths in the network with length: 1 for node SMAD3_S425 and JUN\n", + "looking for paths in the network with length: 2 for node SMAD3_S425 and JUN\n", + "looking for paths in the network with length: 3 for node SMAD3_S425 and JUN\n", + "looking for paths in the network with length: 4 for node SMAD3_S425 and JUN\n", + "looking for paths in the network with length: 5 for node SMAD3_S425 and JUN\n", + "looking for paths in the network with length: 6 for node SMAD3_S425 and JUN\n", + "looking for paths in the network with length: 7 for node SMAD3_S425 and JUN\n", + "looking for paths in the network with length: 8 for node SMAD3_S425 and JUN\n", + "looking for paths in the network with length: 9 for node SMAD3_S425 and JUN\n", + "looking for paths in the network with length: 10 for node SMAD3_S425 and JUN\n", + "i_search = 4\n", + "Looking for paths with length: 0 for node SMAD3_S425 and JUN\n", + "i_search = 4\n", + "Looking for paths with length: 1 for node SMAD3_S425 and JUN\n", + "i_search = 4\n", + "Looking for paths with length: 2 for node SMAD3_S425 and JUN\n", + "i_search = 4\n", + "Looking for paths with length: 3 for node SMAD3_S425 and JUN\n", + "i_search = 4\n", + "Looking for paths with length: 4 for node SMAD3_S425 and JUN\n", + "looking for paths in the network with length: 0 for node SMAD3_S425 and EGFR\n", + "looking for paths in the network with length: 1 for node SMAD3_S425 and EGFR\n", + "looking for paths in the network with length: 2 for node SMAD3_S425 and EGFR\n", + "looking for paths in the network with length: 3 for node SMAD3_S425 and EGFR\n", + "looking for paths in the network with length: 4 for node SMAD3_S425 and EGFR\n", + "looking for paths in the network with length: 5 for node SMAD3_S425 and EGFR\n", + "looking for paths in the network with length: 6 for node SMAD3_S425 and EGFR\n", + "looking for paths in the network with length: 7 for node SMAD3_S425 and EGFR\n", + "looking for paths in the network with length: 8 for node SMAD3_S425 and EGFR\n", + "looking for paths in the network with length: 9 for node SMAD3_S425 and EGFR\n", + "looking for paths in the network with length: 10 for node SMAD3_S425 and EGFR\n", + "i_search = 4\n", + "Looking for paths with length: 0 for node SMAD3_S425 and EGFR\n", + "i_search = 4\n", + "Looking for paths with length: 1 for node SMAD3_S425 and EGFR\n", + "i_search = 4\n", + "Looking for paths with length: 2 for node SMAD3_S425 and EGFR\n", + "i_search = 4\n", + "Looking for paths with length: 3 for node SMAD3_S425 and EGFR\n", + "i_search = 4\n", + "Looking for paths with length: 4 for node SMAD3_S425 and EGFR\n", + "looking for paths in the network with length: 0 for node SMAD3_S425 and MAPK3\n", + "looking for paths in the network with length: 1 for node SMAD3_S425 and MAPK3\n", + "looking for paths in the network with length: 2 for node SMAD3_S425 and MAPK3\n", + "looking for paths in the network with length: 3 for node SMAD3_S425 and MAPK3\n", + "looking for paths in the network with length: 4 for node SMAD3_S425 and MAPK3\n", + "looking for paths in the network with length: 5 for node SMAD3_S425 and MAPK3\n", + "looking for paths in the network with length: 6 for node SMAD3_S425 and MAPK3\n", + "looking for paths in the network with length: 7 for node SMAD3_S425 and MAPK3\n", + "looking for paths in the network with length: 8 for node SMAD3_S425 and MAPK3\n", + "looking for paths in the network with length: 9 for node SMAD3_S425 and MAPK3\n", + "looking for paths in the network with length: 10 for node SMAD3_S425 and MAPK3\n", + "i_search = 4\n", + "Looking for paths with length: 0 for node SMAD3_S425 and MAPK3\n", + "i_search = 4\n", + "Looking for paths with length: 1 for node SMAD3_S425 and MAPK3\n", + "i_search = 4\n", + "Looking for paths with length: 2 for node SMAD3_S425 and MAPK3\n", + "i_search = 4\n", + "Looking for paths with length: 3 for node SMAD3_S425 and MAPK3\n", + "i_search = 4\n", + "Looking for paths with length: 4 for node SMAD3_S425 and MAPK3\n", + "looking for paths in the network with length: 0 for node SMAD3_S425 and PTPN11\n", + "looking for paths in the network with length: 1 for node SMAD3_S425 and PTPN11\n", + "looking for paths in the network with length: 2 for node SMAD3_S425 and PTPN11\n", + "looking for paths in the network with length: 3 for node SMAD3_S425 and PTPN11\n", + "looking for paths in the network with length: 4 for node SMAD3_S425 and PTPN11\n", + "looking for paths in the network with length: 5 for node SMAD3_S425 and PTPN11\n", + "looking for paths in the network with length: 6 for node SMAD3_S425 and PTPN11\n", + "looking for paths in the network with length: 7 for node SMAD3_S425 and PTPN11\n", + "looking for paths in the network with length: 8 for node SMAD3_S425 and PTPN11\n", + "looking for paths in the network with length: 9 for node SMAD3_S425 and PTPN11\n", + "looking for paths in the network with length: 10 for node SMAD3_S425 and PTPN11\n", + "i_search = 4\n", + "Looking for paths with length: 0 for node SMAD3_S425 and PTPN11\n", + "i_search = 4\n", + "Looking for paths with length: 1 for node SMAD3_S425 and PTPN11\n", + "i_search = 4\n", + "Looking for paths with length: 2 for node SMAD3_S425 and PTPN11\n", + "i_search = 4\n", + "Looking for paths with length: 3 for node SMAD3_S425 and PTPN11\n", + "i_search = 4\n", + "Looking for paths with length: 4 for node SMAD3_S425 and PTPN11\n", + "looking for paths in the network with length: 0 for node SMAD3_S425 and STAT3\n", + "looking for paths in the network with length: 1 for node SMAD3_S425 and STAT3\n", + "looking for paths in the network with length: 2 for node SMAD3_S425 and STAT3\n", + "looking for paths in the network with length: 3 for node SMAD3_S425 and STAT3\n", + "looking for paths in the network with length: 4 for node SMAD3_S425 and STAT3\n", + "looking for paths in the network with length: 5 for node SMAD3_S425 and STAT3\n", + "looking for paths in the network with length: 6 for node SMAD3_S425 and STAT3\n", + "looking for paths in the network with length: 7 for node SMAD3_S425 and STAT3\n", + "looking for paths in the network with length: 8 for node SMAD3_S425 and STAT3\n", + "looking for paths in the network with length: 9 for node SMAD3_S425 and STAT3\n", + "looking for paths in the network with length: 10 for node SMAD3_S425 and STAT3\n", + "i_search = 4\n", + "Looking for paths with length: 0 for node SMAD3_S425 and STAT3\n", + "i_search = 4\n", + "Looking for paths with length: 1 for node SMAD3_S425 and STAT3\n", + "i_search = 4\n", + "Looking for paths with length: 2 for node SMAD3_S425 and STAT3\n", + "i_search = 4\n", + "Looking for paths with length: 3 for node SMAD3_S425 and STAT3\n", + "i_search = 4\n", + "Looking for paths with length: 4 for node SMAD3_S425 and STAT3\n", + "looking for paths in the network with length: 0 for node SMAD3_S425 and CHEK2\n", + "looking for paths in the network with length: 1 for node SMAD3_S425 and CHEK2\n", + "looking for paths in the network with length: 2 for node SMAD3_S425 and CHEK2\n", + "looking for paths in the network with length: 3 for node SMAD3_S425 and CHEK2\n", + "looking for paths in the network with length: 4 for node SMAD3_S425 and CHEK2\n", + "looking for paths in the network with length: 5 for node SMAD3_S425 and CHEK2\n", + "looking for paths in the network with length: 6 for node SMAD3_S425 and CHEK2\n", + "looking for paths in the network with length: 7 for node SMAD3_S425 and CHEK2\n", + "looking for paths in the network with length: 8 for node SMAD3_S425 and CHEK2\n", + "looking for paths in the network with length: 9 for node SMAD3_S425 and CHEK2\n", + "looking for paths in the network with length: 10 for node SMAD3_S425 and CHEK2\n", + "i_search = 4\n", + "Looking for paths with length: 0 for node SMAD3_S425 and CHEK2\n", + "i_search = 4\n", + "Looking for paths with length: 1 for node SMAD3_S425 and CHEK2\n", + "i_search = 4\n", + "Looking for paths with length: 2 for node SMAD3_S425 and CHEK2\n", + "i_search = 4\n", + "Looking for paths with length: 3 for node SMAD3_S425 and CHEK2\n", + "i_search = 4\n", + "Looking for paths with length: 4 for node SMAD3_S425 and CHEK2\n", + "looking for paths in the network with length: 0 for node SMAD3_S425 and RELA\n", + "looking for paths in the network with length: 1 for node SMAD3_S425 and RELA\n", + "looking for paths in the network with length: 2 for node SMAD3_S425 and RELA\n", + "looking for paths in the network with length: 3 for node SMAD3_S425 and RELA\n", + "looking for paths in the network with length: 4 for node SMAD3_S425 and RELA\n", + "looking for paths in the network with length: 5 for node SMAD3_S425 and RELA\n", + "looking for paths in the network with length: 6 for node SMAD3_S425 and RELA\n", + "looking for paths in the network with length: 7 for node SMAD3_S425 and RELA\n", + "looking for paths in the network with length: 8 for node SMAD3_S425 and RELA\n", + "looking for paths in the network with length: 9 for node SMAD3_S425 and RELA\n", + "looking for paths in the network with length: 10 for node SMAD3_S425 and RELA\n", + "i_search = 4\n", + "Looking for paths with length: 0 for node SMAD3_S425 and RELA\n", + "i_search = 4\n", + "Looking for paths with length: 1 for node SMAD3_S425 and RELA\n", + "i_search = 4\n", + "Looking for paths with length: 2 for node SMAD3_S425 and RELA\n", + "i_search = 4\n", + "Looking for paths with length: 3 for node SMAD3_S425 and RELA\n", + "i_search = 4\n", + "Looking for paths with length: 4 for node SMAD3_S425 and RELA\n", + "looking for paths in the network with length: 0 for node SMAD3_S425 and MARCKS\n", + "looking for paths in the network with length: 1 for node SMAD3_S425 and MARCKS\n", + "looking for paths in the network with length: 2 for node SMAD3_S425 and MARCKS\n", + "looking for paths in the network with length: 3 for node SMAD3_S425 and MARCKS\n", + "looking for paths in the network with length: 4 for node SMAD3_S425 and MARCKS\n", + "looking for paths in the network with length: 5 for node SMAD3_S425 and MARCKS\n", + "looking for paths in the network with length: 6 for node SMAD3_S425 and MARCKS\n", + "looking for paths in the network with length: 7 for node SMAD3_S425 and MARCKS\n", + "looking for paths in the network with length: 8 for node SMAD3_S425 and MARCKS\n", + "looking for paths in the network with length: 9 for node SMAD3_S425 and MARCKS\n", + "looking for paths in the network with length: 10 for node SMAD3_S425 and MARCKS\n", + "i_search = 4\n", + "Looking for paths with length: 0 for node SMAD3_S425 and MARCKS\n", + "i_search = 4\n", + "Looking for paths with length: 1 for node SMAD3_S425 and MARCKS\n", + "i_search = 4\n", + "Looking for paths with length: 2 for node SMAD3_S425 and MARCKS\n", + "i_search = 4\n", + "Looking for paths with length: 3 for node SMAD3_S425 and MARCKS\n", + "i_search = 4\n", + "Looking for paths with length: 4 for node SMAD3_S425 and MARCKS\n", + "looking for paths in the network with length: 0 for node TP53_S15 and AKT1S1_T246\n", + "looking for paths in the network with length: 1 for node TP53_S15 and AKT1S1_T246\n", + "looking for paths in the network with length: 2 for node TP53_S15 and AKT1S1_T246\n", + "looking for paths in the network with length: 3 for node TP53_S15 and AKT1S1_T246\n", + "looking for paths in the network with length: 4 for node TP53_S15 and AKT1S1_T246\n", + "looking for paths in the network with length: 5 for node TP53_S15 and AKT1S1_T246\n", + "looking for paths in the network with length: 6 for node TP53_S15 and AKT1S1_T246\n", + "looking for paths in the network with length: 7 for node TP53_S15 and AKT1S1_T246\n", + "looking for paths in the network with length: 8 for node TP53_S15 and AKT1S1_T246\n", + "looking for paths in the network with length: 9 for node TP53_S15 and AKT1S1_T246\n", + "looking for paths in the network with length: 10 for node TP53_S15 and AKT1S1_T246\n", + "i_search = 4\n", + "Looking for paths with length: 0 for node TP53_S15 and AKT1S1_T246\n", + "i_search = 4\n", + "Looking for paths with length: 1 for node TP53_S15 and AKT1S1_T246\n", + "i_search = 4\n", + "Looking for paths with length: 2 for node TP53_S15 and AKT1S1_T246\n", + "i_search = 4\n", + "Looking for paths with length: 3 for node TP53_S15 and AKT1S1_T246\n", + "i_search = 4\n", + "Looking for paths with length: 4 for node TP53_S15 and AKT1S1_T246\n", + "looking for paths in the network with length: 0 for node TP53_S15 and GSK3B_S9\n", + "looking for paths in the network with length: 1 for node TP53_S15 and GSK3B_S9\n", + "looking for paths in the network with length: 2 for node TP53_S15 and GSK3B_S9\n", + "looking for paths in the network with length: 3 for node TP53_S15 and GSK3B_S9\n", + "looking for paths in the network with length: 4 for node TP53_S15 and GSK3B_S9\n", + "looking for paths in the network with length: 5 for node TP53_S15 and GSK3B_S9\n", + "looking for paths in the network with length: 6 for node TP53_S15 and GSK3B_S9\n", + "looking for paths in the network with length: 7 for node TP53_S15 and GSK3B_S9\n", + "looking for paths in the network with length: 8 for node TP53_S15 and GSK3B_S9\n", + "looking for paths in the network with length: 9 for node TP53_S15 and GSK3B_S9\n", + "looking for paths in the network with length: 10 for node TP53_S15 and GSK3B_S9\n", + "i_search = 4\n", + "Looking for paths with length: 0 for node TP53_S15 and GSK3B_S9\n", + "i_search = 4\n", + "Looking for paths with length: 1 for node TP53_S15 and GSK3B_S9\n", + "i_search = 4\n", + "Looking for paths with length: 2 for node TP53_S15 and GSK3B_S9\n", + "i_search = 4\n", + "Looking for paths with length: 3 for node TP53_S15 and GSK3B_S9\n", + "i_search = 4\n", + "Looking for paths with length: 4 for node TP53_S15 and GSK3B_S9\n", + "looking for paths in the network with length: 0 for node TP53_S15 and GSK3B_S21\n", + "looking for paths in the network with length: 1 for node TP53_S15 and GSK3B_S21\n", + "looking for paths in the network with length: 2 for node TP53_S15 and GSK3B_S21\n", + "looking for paths in the network with length: 3 for node TP53_S15 and GSK3B_S21\n", + "looking for paths in the network with length: 4 for node TP53_S15 and GSK3B_S21\n", + "looking for paths in the network with length: 5 for node TP53_S15 and GSK3B_S21\n", + "looking for paths in the network with length: 6 for node TP53_S15 and GSK3B_S21\n", + "looking for paths in the network with length: 7 for node TP53_S15 and GSK3B_S21\n", + "looking for paths in the network with length: 8 for node TP53_S15 and GSK3B_S21\n", + "looking for paths in the network with length: 9 for node TP53_S15 and GSK3B_S21\n", + "looking for paths in the network with length: 10 for node TP53_S15 and GSK3B_S21\n", + "i_search = 4\n", + "Looking for paths with length: 0 for node TP53_S15 and GSK3B_S21\n", + "i_search = 4\n", + "Looking for paths with length: 1 for node TP53_S15 and GSK3B_S21\n", + "i_search = 4\n", + "Looking for paths with length: 2 for node TP53_S15 and GSK3B_S21\n", + "i_search = 4\n", + "Looking for paths with length: 3 for node TP53_S15 and GSK3B_S21\n", + "i_search = 4\n", + "Looking for paths with length: 4 for node TP53_S15 and GSK3B_S21\n", + "looking for paths in the network with length: 0 for node TP53_S15 and AKT1_S473\n", + "looking for paths in the network with length: 1 for node TP53_S15 and AKT1_S473\n", + "looking for paths in the network with length: 2 for node TP53_S15 and AKT1_S473\n", + "looking for paths in the network with length: 3 for node TP53_S15 and AKT1_S473\n", + "looking for paths in the network with length: 4 for node TP53_S15 and AKT1_S473\n", + "looking for paths in the network with length: 5 for node TP53_S15 and AKT1_S473\n", + "looking for paths in the network with length: 6 for node TP53_S15 and AKT1_S473\n", + "looking for paths in the network with length: 7 for node TP53_S15 and AKT1_S473\n", + "looking for paths in the network with length: 8 for node TP53_S15 and AKT1_S473\n", + "looking for paths in the network with length: 9 for node TP53_S15 and AKT1_S473\n", + "looking for paths in the network with length: 10 for node TP53_S15 and AKT1_S473\n", + "i_search = 4\n", + "Looking for paths with length: 0 for node TP53_S15 and AKT1_S473\n", + "i_search = 4\n", + "Looking for paths with length: 1 for node TP53_S15 and AKT1_S473\n", + "i_search = 4\n", + "Looking for paths with length: 2 for node TP53_S15 and AKT1_S473\n", + "i_search = 4\n", + "Looking for paths with length: 3 for node TP53_S15 and AKT1_S473\n", + "i_search = 4\n", + "Looking for paths with length: 4 for node TP53_S15 and AKT1_S473\n", + "[['TP53_S15', 'NUAK1', 'NUAK1_S600', 'AKT1', 'AKT1_S473'], ['TP53_S15', 'TP53RK', 'TP53RK_S250', 'AKT1', 'AKT1_S473'], ['TP53_S15', 'CHEK1', 'CHEK1_S280', 'AKT1', 'AKT1_S473']]\n", + "NUAK1 TP53_S15\n", + "NUAK1_S600 NUAK1\n", + "AKT1 NUAK1_S600\n", + "AKT1_S473 AKT1\n", + "TP53RK TP53_S15\n", + "TP53RK_S250 TP53RK\n", + "AKT1 TP53RK_S250\n", + "AKT1_S473 AKT1\n", + "CHEK1 TP53_S15\n", + "CHEK1_S280 CHEK1\n", + "AKT1 CHEK1_S280\n", + "AKT1_S473 AKT1\n", + "looking for paths in the network with length: 0 for node TP53_S15 and HSPB1_S78\n", + "looking for paths in the network with length: 1 for node TP53_S15 and HSPB1_S78\n", + "looking for paths in the network with length: 2 for node TP53_S15 and HSPB1_S78\n", + "looking for paths in the network with length: 3 for node TP53_S15 and HSPB1_S78\n", + "looking for paths in the network with length: 4 for node TP53_S15 and HSPB1_S78\n", + "looking for paths in the network with length: 5 for node TP53_S15 and HSPB1_S78\n", + "looking for paths in the network with length: 6 for node TP53_S15 and HSPB1_S78\n", + "looking for paths in the network with length: 7 for node TP53_S15 and HSPB1_S78\n", + "looking for paths in the network with length: 8 for node TP53_S15 and HSPB1_S78\n", + "looking for paths in the network with length: 9 for node TP53_S15 and HSPB1_S78\n", + "looking for paths in the network with length: 10 for node TP53_S15 and HSPB1_S78\n", + "i_search = 4\n", + "Looking for paths with length: 0 for node TP53_S15 and HSPB1_S78\n", + "i_search = 4\n", + "Looking for paths with length: 1 for node TP53_S15 and HSPB1_S78\n", + "i_search = 4\n", + "Looking for paths with length: 2 for node TP53_S15 and HSPB1_S78\n", + "i_search = 4\n", + "Looking for paths with length: 3 for node TP53_S15 and HSPB1_S78\n", + "i_search = 4\n", + "Looking for paths with length: 4 for node TP53_S15 and HSPB1_S78\n", + "looking for paths in the network with length: 0 for node TP53_S15 and HSPB1_S82\n", + "looking for paths in the network with length: 1 for node TP53_S15 and HSPB1_S82\n", + "looking for paths in the network with length: 2 for node TP53_S15 and HSPB1_S82\n", + "looking for paths in the network with length: 3 for node TP53_S15 and HSPB1_S82\n", + "looking for paths in the network with length: 4 for node TP53_S15 and HSPB1_S82\n", + "looking for paths in the network with length: 5 for node TP53_S15 and HSPB1_S82\n", + "looking for paths in the network with length: 6 for node TP53_S15 and HSPB1_S82\n", + "looking for paths in the network with length: 7 for node TP53_S15 and HSPB1_S82\n", + "looking for paths in the network with length: 8 for node TP53_S15 and HSPB1_S82\n", + "looking for paths in the network with length: 9 for node TP53_S15 and HSPB1_S82\n", + "looking for paths in the network with length: 10 for node TP53_S15 and HSPB1_S82\n", + "i_search = 4\n", + "Looking for paths with length: 0 for node TP53_S15 and HSPB1_S82\n", + "i_search = 4\n", + "Looking for paths with length: 1 for node TP53_S15 and HSPB1_S82\n", + "i_search = 4\n", + "Looking for paths with length: 2 for node TP53_S15 and HSPB1_S82\n", + "i_search = 4\n", + "Looking for paths with length: 3 for node TP53_S15 and HSPB1_S82\n", + "i_search = 4\n", + "Looking for paths with length: 4 for node TP53_S15 and HSPB1_S82\n", + "looking for paths in the network with length: 0 for node TP53_S15 and MAPK14_T180\n", + "looking for paths in the network with length: 1 for node TP53_S15 and MAPK14_T180\n", + "looking for paths in the network with length: 2 for node TP53_S15 and MAPK14_T180\n", + "looking for paths in the network with length: 3 for node TP53_S15 and MAPK14_T180\n", + "looking for paths in the network with length: 4 for node TP53_S15 and MAPK14_T180\n", + "looking for paths in the network with length: 5 for node TP53_S15 and MAPK14_T180\n", + "looking for paths in the network with length: 6 for node TP53_S15 and MAPK14_T180\n", + "looking for paths in the network with length: 7 for node TP53_S15 and MAPK14_T180\n", + "looking for paths in the network with length: 8 for node TP53_S15 and MAPK14_T180\n", + "looking for paths in the network with length: 9 for node TP53_S15 and MAPK14_T180\n", + "looking for paths in the network with length: 10 for node TP53_S15 and MAPK14_T180\n", + "i_search = 4\n", + "Looking for paths with length: 0 for node TP53_S15 and MAPK14_T180\n", + "i_search = 4\n", + "Looking for paths with length: 1 for node TP53_S15 and MAPK14_T180\n", + "i_search = 4\n", + "Looking for paths with length: 2 for node TP53_S15 and MAPK14_T180\n", + "[['TP53_S15', 'MAPK14', 'MAPK14_T180']]\n", + "MAPK14 TP53_S15\n", + "MAPK14_T180 MAPK14\n", + "looking for paths in the network with length: 0 for node TP53_S15 and MAPK14_Y182\n", + "looking for paths in the network with length: 1 for node TP53_S15 and MAPK14_Y182\n", + "looking for paths in the network with length: 2 for node TP53_S15 and MAPK14_Y182\n", + "looking for paths in the network with length: 3 for node TP53_S15 and MAPK14_Y182\n", + "looking for paths in the network with length: 4 for node TP53_S15 and MAPK14_Y182\n", + "looking for paths in the network with length: 5 for node TP53_S15 and MAPK14_Y182\n", + "looking for paths in the network with length: 6 for node TP53_S15 and MAPK14_Y182\n", + "looking for paths in the network with length: 7 for node TP53_S15 and MAPK14_Y182\n", + "looking for paths in the network with length: 8 for node TP53_S15 and MAPK14_Y182\n", + "looking for paths in the network with length: 9 for node TP53_S15 and MAPK14_Y182\n", + "looking for paths in the network with length: 10 for node TP53_S15 and MAPK14_Y182\n", + "i_search = 4\n", + "Looking for paths with length: 0 for node TP53_S15 and MAPK14_Y182\n", + "i_search = 4\n", + "Looking for paths with length: 1 for node TP53_S15 and MAPK14_Y182\n", + "i_search = 4\n", + "Looking for paths with length: 2 for node TP53_S15 and MAPK14_Y182\n", + "[['TP53_S15', 'MAPK14', 'MAPK14_Y182']]\n", + "MAPK14 TP53_S15\n", + "MAPK14_Y182 MAPK14\n", + "looking for paths in the network with length: 0 for node TP53_S15 and MAP2K1_S218\n", + "looking for paths in the network with length: 1 for node TP53_S15 and MAP2K1_S218\n", + "looking for paths in the network with length: 2 for node TP53_S15 and MAP2K1_S218\n", + "looking for paths in the network with length: 3 for node TP53_S15 and MAP2K1_S218\n", + "looking for paths in the network with length: 4 for node TP53_S15 and MAP2K1_S218\n", + "looking for paths in the network with length: 5 for node TP53_S15 and MAP2K1_S218\n", + "looking for paths in the network with length: 6 for node TP53_S15 and MAP2K1_S218\n", + "looking for paths in the network with length: 7 for node TP53_S15 and MAP2K1_S218\n", + "looking for paths in the network with length: 8 for node TP53_S15 and MAP2K1_S218\n", + "looking for paths in the network with length: 9 for node TP53_S15 and MAP2K1_S218\n", + "looking for paths in the network with length: 10 for node TP53_S15 and MAP2K1_S218\n", + "i_search = 4\n", + "Looking for paths with length: 0 for node TP53_S15 and MAP2K1_S218\n", + "i_search = 4\n", + "Looking for paths with length: 1 for node TP53_S15 and MAP2K1_S218\n", + "i_search = 4\n", + "Looking for paths with length: 2 for node TP53_S15 and MAP2K1_S218\n", + "i_search = 4\n", + "Looking for paths with length: 3 for node TP53_S15 and MAP2K1_S218\n", + "i_search = 4\n", + "Looking for paths with length: 4 for node TP53_S15 and MAP2K1_S218\n", + "[['TP53_S15', 'MAPK1', 'MAPK1_Y187', 'MAP2K1', 'MAP2K1_S218'], ['TP53_S15', 'MAPK1', 'MAPK1_T185', 'MAP2K1', 'MAP2K1_S218'], ['TP53_S15', 'MAPK3', 'MAPK3_T207', 'MAP2K1', 'MAP2K1_S218'], ['TP53_S15', 'MAPK3', 'MAPK3_T202', 'MAP2K1', 'MAP2K1_S218'], ['TP53_S15', 'MAPK3', 'MAPK3_Y204', 'MAP2K1', 'MAP2K1_S218']]\n", + "MAPK1 TP53_S15\n", + "MAPK1_Y187 MAPK1\n", + "MAP2K1 MAPK1_Y187\n", + "MAP2K1_S218 MAP2K1\n", + "MAPK1 TP53_S15\n", + "MAPK1_T185 MAPK1\n", + "MAP2K1 MAPK1_T185\n", + "MAP2K1_S218 MAP2K1\n", + "MAPK3 TP53_S15\n", + "MAPK3 MAPK3_T207\n", + "MAP2K1 MAPK3_T207\n", + "MAP2K1_S218 MAP2K1\n", + "MAPK3 TP53_S15\n", + "MAPK3_T202 MAPK3\n", + "MAP2K1 MAPK3_T202\n", + "MAP2K1_S218 MAP2K1\n", + "MAPK3 TP53_S15\n", + "MAPK3 MAPK3_Y204\n", + "MAP2K1 MAPK3_Y204\n", + "MAP2K1_S218 MAP2K1\n", + "looking for paths in the network with length: 0 for node TP53_S15 and MAP2K1_S222\n", + "looking for paths in the network with length: 1 for node TP53_S15 and MAP2K1_S222\n", + "looking for paths in the network with length: 2 for node TP53_S15 and MAP2K1_S222\n", + "looking for paths in the network with length: 3 for node TP53_S15 and MAP2K1_S222\n", + "looking for paths in the network with length: 4 for node TP53_S15 and MAP2K1_S222\n", + "looking for paths in the network with length: 5 for node TP53_S15 and MAP2K1_S222\n", + "looking for paths in the network with length: 6 for node TP53_S15 and MAP2K1_S222\n", + "looking for paths in the network with length: 7 for node TP53_S15 and MAP2K1_S222\n", + "looking for paths in the network with length: 8 for node TP53_S15 and MAP2K1_S222\n", + "looking for paths in the network with length: 9 for node TP53_S15 and MAP2K1_S222\n", + "looking for paths in the network with length: 10 for node TP53_S15 and MAP2K1_S222\n", + "i_search = 4\n", + "Looking for paths with length: 0 for node TP53_S15 and MAP2K1_S222\n", + "i_search = 4\n", + "Looking for paths with length: 1 for node TP53_S15 and MAP2K1_S222\n", + "i_search = 4\n", + "Looking for paths with length: 2 for node TP53_S15 and MAP2K1_S222\n", + "i_search = 4\n", + "Looking for paths with length: 3 for node TP53_S15 and MAP2K1_S222\n", + "i_search = 4\n", + "Looking for paths with length: 4 for node TP53_S15 and MAP2K1_S222\n", + "[['TP53_S15', 'MAPK1', 'MAPK1_Y187', 'MAP2K1', 'MAP2K1_S222'], ['TP53_S15', 'MAPK1', 'MAPK1_T185', 'MAP2K1', 'MAP2K1_S222'], ['TP53_S15', 'MAPK3', 'MAPK3_T207', 'MAP2K1', 'MAP2K1_S222'], ['TP53_S15', 'MAPK3', 'MAPK3_T202', 'MAP2K1', 'MAP2K1_S222'], ['TP53_S15', 'MAPK3', 'MAPK3_Y204', 'MAP2K1', 'MAP2K1_S222']]\n", + "MAPK1 TP53_S15\n", + "MAPK1_Y187 MAPK1\n", + "MAP2K1 MAPK1_Y187\n", + "MAP2K1_S222 MAP2K1\n", + "MAPK1 TP53_S15\n", + "MAPK1_T185 MAPK1\n", + "MAP2K1 MAPK1_T185\n", + "MAP2K1_S222 MAP2K1\n", + "MAPK3 TP53_S15\n", + "MAPK3 MAPK3_T207\n", + "MAP2K1 MAPK3_T207\n", + "MAP2K1_S222 MAP2K1\n", + "MAPK3 TP53_S15\n", + "MAPK3_T202 MAPK3\n", + "MAP2K1 MAPK3_T202\n", + "MAP2K1_S222 MAP2K1\n", + "MAPK3 TP53_S15\n", + "MAPK3 MAPK3_Y204\n", + "MAP2K1 MAPK3_Y204\n", + "MAP2K1_S222 MAP2K1\n", + "looking for paths in the network with length: 0 for node TP53_S15 and RPS6KA1_S380\n", + "looking for paths in the network with length: 1 for node TP53_S15 and RPS6KA1_S380\n", + "looking for paths in the network with length: 2 for node TP53_S15 and RPS6KA1_S380\n", + "looking for paths in the network with length: 3 for node TP53_S15 and RPS6KA1_S380\n", + "looking for paths in the network with length: 4 for node TP53_S15 and RPS6KA1_S380\n", + "looking for paths in the network with length: 5 for node TP53_S15 and RPS6KA1_S380\n", + "looking for paths in the network with length: 6 for node TP53_S15 and RPS6KA1_S380\n", + "looking for paths in the network with length: 7 for node TP53_S15 and RPS6KA1_S380\n", + "looking for paths in the network with length: 8 for node TP53_S15 and RPS6KA1_S380\n", + "looking for paths in the network with length: 9 for node TP53_S15 and RPS6KA1_S380\n", + "looking for paths in the network with length: 10 for node TP53_S15 and RPS6KA1_S380\n", + "i_search = 4\n", + "Looking for paths with length: 0 for node TP53_S15 and RPS6KA1_S380\n", + "i_search = 4\n", + "Looking for paths with length: 1 for node TP53_S15 and RPS6KA1_S380\n", + "i_search = 4\n", + "Looking for paths with length: 2 for node TP53_S15 and RPS6KA1_S380\n", + "i_search = 4\n", + "Looking for paths with length: 3 for node TP53_S15 and RPS6KA1_S380\n", + "i_search = 4\n", + "Looking for paths with length: 4 for node TP53_S15 and RPS6KA1_S380\n", + "[['TP53_S15', 'CHEK1', 'CHEK1_S280', 'RPS6KA1', 'RPS6KA1_S380']]\n", + "CHEK1 TP53_S15\n", + "CHEK1_S280 CHEK1\n", + "RPS6KA1 CHEK1_S280\n", + "RPS6KA1 RPS6KA1_S380\n", + "looking for paths in the network with length: 0 for node TP53_S15 and CREB1_S133\n", + "looking for paths in the network with length: 1 for node TP53_S15 and CREB1_S133\n", + "looking for paths in the network with length: 2 for node TP53_S15 and CREB1_S133\n", + "looking for paths in the network with length: 3 for node TP53_S15 and CREB1_S133\n", + "looking for paths in the network with length: 4 for node TP53_S15 and CREB1_S133\n", + "looking for paths in the network with length: 5 for node TP53_S15 and CREB1_S133\n", + "looking for paths in the network with length: 6 for node TP53_S15 and CREB1_S133\n", + "looking for paths in the network with length: 7 for node TP53_S15 and CREB1_S133\n", + "looking for paths in the network with length: 8 for node TP53_S15 and CREB1_S133\n", + "looking for paths in the network with length: 9 for node TP53_S15 and CREB1_S133\n", + "looking for paths in the network with length: 10 for node TP53_S15 and CREB1_S133\n", + "i_search = 4\n", + "Looking for paths with length: 0 for node TP53_S15 and CREB1_S133\n", + "i_search = 4\n", + "Looking for paths with length: 1 for node TP53_S15 and CREB1_S133\n", + "i_search = 4\n", + "Looking for paths with length: 2 for node TP53_S15 and CREB1_S133\n", + "i_search = 4\n", + "Looking for paths with length: 3 for node TP53_S15 and CREB1_S133\n", + "i_search = 4\n", + "Looking for paths with length: 4 for node TP53_S15 and CREB1_S133\n", + "looking for paths in the network with length: 0 for node TP53_S15 and NFKBIA_S32\n", + "looking for paths in the network with length: 1 for node TP53_S15 and NFKBIA_S32\n", + "looking for paths in the network with length: 2 for node TP53_S15 and NFKBIA_S32\n", + "looking for paths in the network with length: 3 for node TP53_S15 and NFKBIA_S32\n", + "looking for paths in the network with length: 4 for node TP53_S15 and NFKBIA_S32\n", + "looking for paths in the network with length: 5 for node TP53_S15 and NFKBIA_S32\n", + "looking for paths in the network with length: 6 for node TP53_S15 and NFKBIA_S32\n", + "looking for paths in the network with length: 7 for node TP53_S15 and NFKBIA_S32\n", + "looking for paths in the network with length: 8 for node TP53_S15 and NFKBIA_S32\n", + "looking for paths in the network with length: 9 for node TP53_S15 and NFKBIA_S32\n", + "looking for paths in the network with length: 10 for node TP53_S15 and NFKBIA_S32\n", + "i_search = 4\n", + "Looking for paths with length: 0 for node TP53_S15 and NFKBIA_S32\n", + "i_search = 4\n", + "Looking for paths with length: 1 for node TP53_S15 and NFKBIA_S32\n", + "i_search = 4\n", + "Looking for paths with length: 2 for node TP53_S15 and NFKBIA_S32\n", + "i_search = 4\n", + "Looking for paths with length: 3 for node TP53_S15 and NFKBIA_S32\n", + "i_search = 4\n", + "Looking for paths with length: 4 for node TP53_S15 and NFKBIA_S32\n", + "looking for paths in the network with length: 0 for node TP53_S15 and NFKBIA_S36\n", + "looking for paths in the network with length: 1 for node TP53_S15 and NFKBIA_S36\n", + "looking for paths in the network with length: 2 for node TP53_S15 and NFKBIA_S36\n", + "looking for paths in the network with length: 3 for node TP53_S15 and NFKBIA_S36\n", + "looking for paths in the network with length: 4 for node TP53_S15 and NFKBIA_S36\n", + "looking for paths in the network with length: 5 for node TP53_S15 and NFKBIA_S36\n", + "looking for paths in the network with length: 6 for node TP53_S15 and NFKBIA_S36\n", + "looking for paths in the network with length: 7 for node TP53_S15 and NFKBIA_S36\n", + "looking for paths in the network with length: 8 for node TP53_S15 and NFKBIA_S36\n", + "looking for paths in the network with length: 9 for node TP53_S15 and NFKBIA_S36\n", + "looking for paths in the network with length: 10 for node TP53_S15 and NFKBIA_S36\n", + "i_search = 4\n", + "Looking for paths with length: 0 for node TP53_S15 and NFKBIA_S36\n", + "i_search = 4\n", + "Looking for paths with length: 1 for node TP53_S15 and NFKBIA_S36\n", + "i_search = 4\n", + "Looking for paths with length: 2 for node TP53_S15 and NFKBIA_S36\n", + "i_search = 4\n", + "Looking for paths with length: 3 for node TP53_S15 and NFKBIA_S36\n", + "i_search = 4\n", + "Looking for paths with length: 4 for node TP53_S15 and NFKBIA_S36\n", + "looking for paths in the network with length: 0 for node TP53_S15 and MTOR_S2448\n", + "looking for paths in the network with length: 1 for node TP53_S15 and MTOR_S2448\n", + "looking for paths in the network with length: 2 for node TP53_S15 and MTOR_S2448\n", + "looking for paths in the network with length: 3 for node TP53_S15 and MTOR_S2448\n", + "looking for paths in the network with length: 4 for node TP53_S15 and MTOR_S2448\n", + "looking for paths in the network with length: 5 for node TP53_S15 and MTOR_S2448\n", + "looking for paths in the network with length: 6 for node TP53_S15 and MTOR_S2448\n", + "looking for paths in the network with length: 7 for node TP53_S15 and MTOR_S2448\n", + "looking for paths in the network with length: 8 for node TP53_S15 and MTOR_S2448\n", + "looking for paths in the network with length: 9 for node TP53_S15 and MTOR_S2448\n", + "looking for paths in the network with length: 10 for node TP53_S15 and MTOR_S2448\n", + "i_search = 4\n", + "Looking for paths with length: 0 for node TP53_S15 and MTOR_S2448\n", + "i_search = 4\n", + "Looking for paths with length: 1 for node TP53_S15 and MTOR_S2448\n", + "i_search = 4\n", + "Looking for paths with length: 2 for node TP53_S15 and MTOR_S2448\n", + "i_search = 4\n", + "Looking for paths with length: 3 for node TP53_S15 and MTOR_S2448\n", + "i_search = 4\n", + "Looking for paths with length: 4 for node TP53_S15 and MTOR_S2448\n", + "looking for paths in the network with length: 0 for node TP53_S15 and JUN_S63\n", + "looking for paths in the network with length: 1 for node TP53_S15 and JUN_S63\n", + "looking for paths in the network with length: 2 for node TP53_S15 and JUN_S63\n", + "looking for paths in the network with length: 3 for node TP53_S15 and JUN_S63\n", + "looking for paths in the network with length: 4 for node TP53_S15 and JUN_S63\n", + "looking for paths in the network with length: 5 for node TP53_S15 and JUN_S63\n", + "looking for paths in the network with length: 6 for node TP53_S15 and JUN_S63\n", + "looking for paths in the network with length: 7 for node TP53_S15 and JUN_S63\n", + "looking for paths in the network with length: 8 for node TP53_S15 and JUN_S63\n", + "looking for paths in the network with length: 9 for node TP53_S15 and JUN_S63\n", + "looking for paths in the network with length: 10 for node TP53_S15 and JUN_S63\n", + "i_search = 4\n", + "Looking for paths with length: 0 for node TP53_S15 and JUN_S63\n", + "i_search = 4\n", + "Looking for paths with length: 1 for node TP53_S15 and JUN_S63\n", + "i_search = 4\n", + "Looking for paths with length: 2 for node TP53_S15 and JUN_S63\n", + "i_search = 4\n", + "Looking for paths with length: 3 for node TP53_S15 and JUN_S63\n", + "i_search = 4\n", + "Looking for paths with length: 4 for node TP53_S15 and JUN_S63\n", + "looking for paths in the network with length: 0 for node TP53_S15 and EGFR_Y1068\n", + "looking for paths in the network with length: 1 for node TP53_S15 and EGFR_Y1068\n", + "looking for paths in the network with length: 2 for node TP53_S15 and EGFR_Y1068\n", + "looking for paths in the network with length: 3 for node TP53_S15 and EGFR_Y1068\n", + "looking for paths in the network with length: 4 for node TP53_S15 and EGFR_Y1068\n", + "looking for paths in the network with length: 5 for node TP53_S15 and EGFR_Y1068\n", + "looking for paths in the network with length: 6 for node TP53_S15 and EGFR_Y1068\n", + "looking for paths in the network with length: 7 for node TP53_S15 and EGFR_Y1068\n", + "looking for paths in the network with length: 8 for node TP53_S15 and EGFR_Y1068\n", + "looking for paths in the network with length: 9 for node TP53_S15 and EGFR_Y1068\n", + "looking for paths in the network with length: 10 for node TP53_S15 and EGFR_Y1068\n", + "i_search = 4\n", + "Looking for paths with length: 0 for node TP53_S15 and EGFR_Y1068\n", + "i_search = 4\n", + "Looking for paths with length: 1 for node TP53_S15 and EGFR_Y1068\n", + "i_search = 4\n", + "Looking for paths with length: 2 for node TP53_S15 and EGFR_Y1068\n", + "i_search = 4\n", + "Looking for paths with length: 3 for node TP53_S15 and EGFR_Y1068\n", + "i_search = 4\n", + "Looking for paths with length: 4 for node TP53_S15 and EGFR_Y1068\n", + "looking for paths in the network with length: 0 for node TP53_S15 and MAPK3_T202\n", + "looking for paths in the network with length: 1 for node TP53_S15 and MAPK3_T202\n", + "looking for paths in the network with length: 2 for node TP53_S15 and MAPK3_T202\n", + "Found a path!\n", + "[['TP53_S15', 'MAPK3', 'MAPK3_T202']]\n", + "looking for paths in the network with length: 0 for node TP53_S15 and MAPK3_Y204\n", + "looking for paths in the network with length: 1 for node TP53_S15 and MAPK3_Y204\n", + "looking for paths in the network with length: 2 for node TP53_S15 and MAPK3_Y204\n", + "looking for paths in the network with length: 3 for node TP53_S15 and MAPK3_Y204\n", + "looking for paths in the network with length: 4 for node TP53_S15 and MAPK3_Y204\n", + "looking for paths in the network with length: 5 for node TP53_S15 and MAPK3_Y204\n", + "looking for paths in the network with length: 6 for node TP53_S15 and MAPK3_Y204\n", + "looking for paths in the network with length: 7 for node TP53_S15 and MAPK3_Y204\n", + "looking for paths in the network with length: 8 for node TP53_S15 and MAPK3_Y204\n", + "looking for paths in the network with length: 9 for node TP53_S15 and MAPK3_Y204\n", + "looking for paths in the network with length: 10 for node TP53_S15 and MAPK3_Y204\n", + "i_search = 4\n", + "Looking for paths with length: 0 for node TP53_S15 and MAPK3_Y204\n", + "i_search = 4\n", + "Looking for paths with length: 1 for node TP53_S15 and MAPK3_Y204\n", + "i_search = 4\n", + "Looking for paths with length: 2 for node TP53_S15 and MAPK3_Y204\n", + "[['TP53_S15', 'MAPK3', 'MAPK3_Y204']]\n", + "MAPK3 TP53_S15\n", + "MAPK3 MAPK3_Y204\n", + "looking for paths in the network with length: 0 for node TP53_S15 and PTPN11_Y542\n", + "looking for paths in the network with length: 1 for node TP53_S15 and PTPN11_Y542\n", + "looking for paths in the network with length: 2 for node TP53_S15 and PTPN11_Y542\n", + "looking for paths in the network with length: 3 for node TP53_S15 and PTPN11_Y542\n", + "looking for paths in the network with length: 4 for node TP53_S15 and PTPN11_Y542\n", + "looking for paths in the network with length: 5 for node TP53_S15 and PTPN11_Y542\n", + "looking for paths in the network with length: 6 for node TP53_S15 and PTPN11_Y542\n", + "looking for paths in the network with length: 7 for node TP53_S15 and PTPN11_Y542\n", + "looking for paths in the network with length: 8 for node TP53_S15 and PTPN11_Y542\n", + "looking for paths in the network with length: 9 for node TP53_S15 and PTPN11_Y542\n", + "looking for paths in the network with length: 10 for node TP53_S15 and PTPN11_Y542\n", + "i_search = 4\n", + "Looking for paths with length: 0 for node TP53_S15 and PTPN11_Y542\n", + "i_search = 4\n", + "Looking for paths with length: 1 for node TP53_S15 and PTPN11_Y542\n", + "i_search = 4\n", + "Looking for paths with length: 2 for node TP53_S15 and PTPN11_Y542\n", + "i_search = 4\n", + "Looking for paths with length: 3 for node TP53_S15 and PTPN11_Y542\n", + "i_search = 4\n", + "Looking for paths with length: 4 for node TP53_S15 and PTPN11_Y542\n", + "looking for paths in the network with length: 0 for node TP53_S15 and STAT3_Y705\n", + "looking for paths in the network with length: 1 for node TP53_S15 and STAT3_Y705\n", + "looking for paths in the network with length: 2 for node TP53_S15 and STAT3_Y705\n", + "looking for paths in the network with length: 3 for node TP53_S15 and STAT3_Y705\n", + "looking for paths in the network with length: 4 for node TP53_S15 and STAT3_Y705\n", + "looking for paths in the network with length: 5 for node TP53_S15 and STAT3_Y705\n", + "looking for paths in the network with length: 6 for node TP53_S15 and STAT3_Y705\n", + "looking for paths in the network with length: 7 for node TP53_S15 and STAT3_Y705\n", + "looking for paths in the network with length: 8 for node TP53_S15 and STAT3_Y705\n", + "looking for paths in the network with length: 9 for node TP53_S15 and STAT3_Y705\n", + "looking for paths in the network with length: 10 for node TP53_S15 and STAT3_Y705\n", + "i_search = 4\n", + "Looking for paths with length: 0 for node TP53_S15 and STAT3_Y705\n", + "i_search = 4\n", + "Looking for paths with length: 1 for node TP53_S15 and STAT3_Y705\n", + "i_search = 4\n", + "Looking for paths with length: 2 for node TP53_S15 and STAT3_Y705\n", + "i_search = 4\n", + "Looking for paths with length: 3 for node TP53_S15 and STAT3_Y705\n", + "i_search = 4\n", + "Looking for paths with length: 4 for node TP53_S15 and STAT3_Y705\n", + "looking for paths in the network with length: 0 for node TP53_S15 and CHEK2_T68\n", + "looking for paths in the network with length: 1 for node TP53_S15 and CHEK2_T68\n", + "looking for paths in the network with length: 2 for node TP53_S15 and CHEK2_T68\n", + "looking for paths in the network with length: 3 for node TP53_S15 and CHEK2_T68\n", + "looking for paths in the network with length: 4 for node TP53_S15 and CHEK2_T68\n", + "looking for paths in the network with length: 5 for node TP53_S15 and CHEK2_T68\n", + "looking for paths in the network with length: 6 for node TP53_S15 and CHEK2_T68\n", + "looking for paths in the network with length: 7 for node TP53_S15 and CHEK2_T68\n", + "looking for paths in the network with length: 8 for node TP53_S15 and CHEK2_T68\n", + "looking for paths in the network with length: 9 for node TP53_S15 and CHEK2_T68\n", + "looking for paths in the network with length: 10 for node TP53_S15 and CHEK2_T68\n", + "i_search = 4\n", + "Looking for paths with length: 0 for node TP53_S15 and CHEK2_T68\n", + "i_search = 4\n", + "Looking for paths with length: 1 for node TP53_S15 and CHEK2_T68\n", + "i_search = 4\n", + "Looking for paths with length: 2 for node TP53_S15 and CHEK2_T68\n", + "[['TP53_S15', 'CHEK2', 'CHEK2_T68']]\n", + "CHEK2 TP53_S15\n", + "CHEK2 CHEK2_T68\n", + "looking for paths in the network with length: 0 for node TP53_S15 and RELA_S536\n", + "looking for paths in the network with length: 1 for node TP53_S15 and RELA_S536\n", + "looking for paths in the network with length: 2 for node TP53_S15 and RELA_S536\n", + "looking for paths in the network with length: 3 for node TP53_S15 and RELA_S536\n", + "looking for paths in the network with length: 4 for node TP53_S15 and RELA_S536\n", + "looking for paths in the network with length: 5 for node TP53_S15 and RELA_S536\n", + "looking for paths in the network with length: 6 for node TP53_S15 and RELA_S536\n", + "looking for paths in the network with length: 7 for node TP53_S15 and RELA_S536\n", + "looking for paths in the network with length: 8 for node TP53_S15 and RELA_S536\n", + "looking for paths in the network with length: 9 for node TP53_S15 and RELA_S536\n", + "looking for paths in the network with length: 10 for node TP53_S15 and RELA_S536\n", + "i_search = 4\n", + "Looking for paths with length: 0 for node TP53_S15 and RELA_S536\n", + "i_search = 4\n", + "Looking for paths with length: 1 for node TP53_S15 and RELA_S536\n", + "i_search = 4\n", + "Looking for paths with length: 2 for node TP53_S15 and RELA_S536\n", + "i_search = 4\n", + "Looking for paths with length: 3 for node TP53_S15 and RELA_S536\n", + "i_search = 4\n", + "Looking for paths with length: 4 for node TP53_S15 and RELA_S536\n", + "looking for paths in the network with length: 0 for node TP53_S15 and MARCKS_S170\n", + "looking for paths in the network with length: 1 for node TP53_S15 and MARCKS_S170\n", + "looking for paths in the network with length: 2 for node TP53_S15 and MARCKS_S170\n", + "looking for paths in the network with length: 3 for node TP53_S15 and MARCKS_S170\n", + "looking for paths in the network with length: 4 for node TP53_S15 and MARCKS_S170\n", + "looking for paths in the network with length: 5 for node TP53_S15 and MARCKS_S170\n", + "looking for paths in the network with length: 6 for node TP53_S15 and MARCKS_S170\n", + "looking for paths in the network with length: 7 for node TP53_S15 and MARCKS_S170\n", + "looking for paths in the network with length: 8 for node TP53_S15 and MARCKS_S170\n", + "looking for paths in the network with length: 9 for node TP53_S15 and MARCKS_S170\n", + "looking for paths in the network with length: 10 for node TP53_S15 and MARCKS_S170\n", + "i_search = 4\n", + "Looking for paths with length: 0 for node TP53_S15 and MARCKS_S170\n", + "i_search = 4\n", + "Looking for paths with length: 1 for node TP53_S15 and MARCKS_S170\n", + "i_search = 4\n", + "Looking for paths with length: 2 for node TP53_S15 and MARCKS_S170\n", + "i_search = 4\n", + "Looking for paths with length: 3 for node TP53_S15 and MARCKS_S170\n", + "i_search = 4\n", + "Looking for paths with length: 4 for node TP53_S15 and MARCKS_S170\n", + "looking for paths in the network with length: 0 for node TP53_S15 and SMAD3\n", + "looking for paths in the network with length: 1 for node TP53_S15 and SMAD3\n", + "looking for paths in the network with length: 2 for node TP53_S15 and SMAD3\n", + "looking for paths in the network with length: 3 for node TP53_S15 and SMAD3\n", + "looking for paths in the network with length: 4 for node TP53_S15 and SMAD3\n", + "looking for paths in the network with length: 5 for node TP53_S15 and SMAD3\n", + "looking for paths in the network with length: 6 for node TP53_S15 and SMAD3\n", + "looking for paths in the network with length: 7 for node TP53_S15 and SMAD3\n", + "looking for paths in the network with length: 8 for node TP53_S15 and SMAD3\n", + "looking for paths in the network with length: 9 for node TP53_S15 and SMAD3\n", + "looking for paths in the network with length: 10 for node TP53_S15 and SMAD3\n", + "i_search = 4\n", + "Looking for paths with length: 0 for node TP53_S15 and SMAD3\n", + "i_search = 4\n", + "Looking for paths with length: 1 for node TP53_S15 and SMAD3\n", + "i_search = 4\n", + "Looking for paths with length: 2 for node TP53_S15 and SMAD3\n", + "i_search = 4\n", + "Looking for paths with length: 3 for node TP53_S15 and SMAD3\n", + "i_search = 4\n", + "Looking for paths with length: 4 for node TP53_S15 and SMAD3\n", + "looking for paths in the network with length: 0 for node TP53_S15 and TP53\n", + "looking for paths in the network with length: 1 for node TP53_S15 and TP53\n", + "looking for paths in the network with length: 2 for node TP53_S15 and TP53\n", + "looking for paths in the network with length: 3 for node TP53_S15 and TP53\n", + "looking for paths in the network with length: 4 for node TP53_S15 and TP53\n", + "looking for paths in the network with length: 5 for node TP53_S15 and TP53\n", + "looking for paths in the network with length: 6 for node TP53_S15 and TP53\n", + "looking for paths in the network with length: 7 for node TP53_S15 and TP53\n", + "looking for paths in the network with length: 8 for node TP53_S15 and TP53\n", + "looking for paths in the network with length: 9 for node TP53_S15 and TP53\n", + "looking for paths in the network with length: 10 for node TP53_S15 and TP53\n", + "i_search = 4\n", + "Looking for paths with length: 0 for node TP53_S15 and TP53\n", + "i_search = 4\n", + "Looking for paths with length: 1 for node TP53_S15 and TP53\n", + "i_search = 4\n", + "Looking for paths with length: 2 for node TP53_S15 and TP53\n", + "i_search = 4\n", + "Looking for paths with length: 3 for node TP53_S15 and TP53\n", + "i_search = 4\n", + "Looking for paths with length: 4 for node TP53_S15 and TP53\n", + "looking for paths in the network with length: 0 for node TP53_S15 and AKT1S1\n", + "looking for paths in the network with length: 1 for node TP53_S15 and AKT1S1\n", + "looking for paths in the network with length: 2 for node TP53_S15 and AKT1S1\n", + "looking for paths in the network with length: 3 for node TP53_S15 and AKT1S1\n", + "looking for paths in the network with length: 4 for node TP53_S15 and AKT1S1\n", + "looking for paths in the network with length: 5 for node TP53_S15 and AKT1S1\n", + "looking for paths in the network with length: 6 for node TP53_S15 and AKT1S1\n", + "looking for paths in the network with length: 7 for node TP53_S15 and AKT1S1\n", + "looking for paths in the network with length: 8 for node TP53_S15 and AKT1S1\n", + "looking for paths in the network with length: 9 for node TP53_S15 and AKT1S1\n", + "looking for paths in the network with length: 10 for node TP53_S15 and AKT1S1\n", + "i_search = 4\n", + "Looking for paths with length: 0 for node TP53_S15 and AKT1S1\n", + "i_search = 4\n", + "Looking for paths with length: 1 for node TP53_S15 and AKT1S1\n", + "i_search = 4\n", + "Looking for paths with length: 2 for node TP53_S15 and AKT1S1\n", + "i_search = 4\n", + "Looking for paths with length: 3 for node TP53_S15 and AKT1S1\n", + "i_search = 4\n", + "Looking for paths with length: 4 for node TP53_S15 and AKT1S1\n", + "looking for paths in the network with length: 0 for node TP53_S15 and GSK3B\n", + "looking for paths in the network with length: 1 for node TP53_S15 and GSK3B\n", + "looking for paths in the network with length: 2 for node TP53_S15 and GSK3B\n", + "looking for paths in the network with length: 3 for node TP53_S15 and GSK3B\n", + "looking for paths in the network with length: 4 for node TP53_S15 and GSK3B\n", + "looking for paths in the network with length: 5 for node TP53_S15 and GSK3B\n", + "looking for paths in the network with length: 6 for node TP53_S15 and GSK3B\n", + "looking for paths in the network with length: 7 for node TP53_S15 and GSK3B\n", + "looking for paths in the network with length: 8 for node TP53_S15 and GSK3B\n", + "looking for paths in the network with length: 9 for node TP53_S15 and GSK3B\n", + "looking for paths in the network with length: 10 for node TP53_S15 and GSK3B\n", + "i_search = 4\n", + "Looking for paths with length: 0 for node TP53_S15 and GSK3B\n", + "i_search = 4\n", + "Looking for paths with length: 1 for node TP53_S15 and GSK3B\n", + "i_search = 4\n", + "Looking for paths with length: 2 for node TP53_S15 and GSK3B\n", + "i_search = 4\n", + "Looking for paths with length: 3 for node TP53_S15 and GSK3B\n", + "i_search = 4\n", + "Looking for paths with length: 4 for node TP53_S15 and GSK3B\n", + "looking for paths in the network with length: 0 for node TP53_S15 and AKT1\n", + "looking for paths in the network with length: 1 for node TP53_S15 and AKT1\n", + "looking for paths in the network with length: 2 for node TP53_S15 and AKT1\n", + "looking for paths in the network with length: 3 for node TP53_S15 and AKT1\n", + "looking for paths in the network with length: 4 for node TP53_S15 and AKT1\n", + "looking for paths in the network with length: 5 for node TP53_S15 and AKT1\n", + "looking for paths in the network with length: 6 for node TP53_S15 and AKT1\n", + "looking for paths in the network with length: 7 for node TP53_S15 and AKT1\n", + "looking for paths in the network with length: 8 for node TP53_S15 and AKT1\n", + "looking for paths in the network with length: 9 for node TP53_S15 and AKT1\n", + "looking for paths in the network with length: 10 for node TP53_S15 and AKT1\n", + "i_search = 4\n", + "Looking for paths with length: 0 for node TP53_S15 and AKT1\n", + "i_search = 4\n", + "Looking for paths with length: 1 for node TP53_S15 and AKT1\n", + "i_search = 4\n", + "Looking for paths with length: 2 for node TP53_S15 and AKT1\n", + "i_search = 4\n", + "Looking for paths with length: 3 for node TP53_S15 and AKT1\n", + "i_search = 4\n", + "Looking for paths with length: 4 for node TP53_S15 and AKT1\n", + "looking for paths in the network with length: 0 for node TP53_S15 and HSPB1\n", + "looking for paths in the network with length: 1 for node TP53_S15 and HSPB1\n", + "looking for paths in the network with length: 2 for node TP53_S15 and HSPB1\n", + "looking for paths in the network with length: 3 for node TP53_S15 and HSPB1\n", + "looking for paths in the network with length: 4 for node TP53_S15 and HSPB1\n", + "looking for paths in the network with length: 5 for node TP53_S15 and HSPB1\n", + "looking for paths in the network with length: 6 for node TP53_S15 and HSPB1\n", + "looking for paths in the network with length: 7 for node TP53_S15 and HSPB1\n", + "looking for paths in the network with length: 8 for node TP53_S15 and HSPB1\n", + "looking for paths in the network with length: 9 for node TP53_S15 and HSPB1\n", + "looking for paths in the network with length: 10 for node TP53_S15 and HSPB1\n", + "i_search = 4\n", + "Looking for paths with length: 0 for node TP53_S15 and HSPB1\n", + "i_search = 4\n", + "Looking for paths with length: 1 for node TP53_S15 and HSPB1\n", + "i_search = 4\n", + "Looking for paths with length: 2 for node TP53_S15 and HSPB1\n", + "i_search = 4\n", + "Looking for paths with length: 3 for node TP53_S15 and HSPB1\n", + "i_search = 4\n", + "Looking for paths with length: 4 for node TP53_S15 and HSPB1\n", + "looking for paths in the network with length: 0 for node TP53_S15 and MAPK14\n", + "looking for paths in the network with length: 1 for node TP53_S15 and MAPK14\n", + "looking for paths in the network with length: 2 for node TP53_S15 and MAPK14\n", + "looking for paths in the network with length: 3 for node TP53_S15 and MAPK14\n", + "looking for paths in the network with length: 4 for node TP53_S15 and MAPK14\n", + "looking for paths in the network with length: 5 for node TP53_S15 and MAPK14\n", + "looking for paths in the network with length: 6 for node TP53_S15 and MAPK14\n", + "looking for paths in the network with length: 7 for node TP53_S15 and MAPK14\n", + "looking for paths in the network with length: 8 for node TP53_S15 and MAPK14\n", + "looking for paths in the network with length: 9 for node TP53_S15 and MAPK14\n", + "looking for paths in the network with length: 10 for node TP53_S15 and MAPK14\n", + "i_search = 4\n", + "Looking for paths with length: 0 for node TP53_S15 and MAPK14\n", + "i_search = 4\n", + "Looking for paths with length: 1 for node TP53_S15 and MAPK14\n", + "i_search = 4\n", + "Looking for paths with length: 2 for node TP53_S15 and MAPK14\n", + "i_search = 4\n", + "Looking for paths with length: 3 for node TP53_S15 and MAPK14\n", + "i_search = 4\n", + "Looking for paths with length: 4 for node TP53_S15 and MAPK14\n", + "looking for paths in the network with length: 0 for node TP53_S15 and MAP2K1\n", + "looking for paths in the network with length: 1 for node TP53_S15 and MAP2K1\n", + "looking for paths in the network with length: 2 for node TP53_S15 and MAP2K1\n", + "looking for paths in the network with length: 3 for node TP53_S15 and MAP2K1\n", + "looking for paths in the network with length: 4 for node TP53_S15 and MAP2K1\n", + "looking for paths in the network with length: 5 for node TP53_S15 and MAP2K1\n", + "looking for paths in the network with length: 6 for node TP53_S15 and MAP2K1\n", + "looking for paths in the network with length: 7 for node TP53_S15 and MAP2K1\n", + "looking for paths in the network with length: 8 for node TP53_S15 and MAP2K1\n", + "looking for paths in the network with length: 9 for node TP53_S15 and MAP2K1\n", + "looking for paths in the network with length: 10 for node TP53_S15 and MAP2K1\n", + "i_search = 4\n", + "Looking for paths with length: 0 for node TP53_S15 and MAP2K1\n", + "i_search = 4\n", + "Looking for paths with length: 1 for node TP53_S15 and MAP2K1\n", + "i_search = 4\n", + "Looking for paths with length: 2 for node TP53_S15 and MAP2K1\n", + "i_search = 4\n", + "Looking for paths with length: 3 for node TP53_S15 and MAP2K1\n", + "i_search = 4\n", + "Looking for paths with length: 4 for node TP53_S15 and MAP2K1\n", + "looking for paths in the network with length: 0 for node TP53_S15 and RPS6KA1\n", + "looking for paths in the network with length: 1 for node TP53_S15 and RPS6KA1\n", + "looking for paths in the network with length: 2 for node TP53_S15 and RPS6KA1\n", + "looking for paths in the network with length: 3 for node TP53_S15 and RPS6KA1\n", + "looking for paths in the network with length: 4 for node TP53_S15 and RPS6KA1\n", + "looking for paths in the network with length: 5 for node TP53_S15 and RPS6KA1\n", + "looking for paths in the network with length: 6 for node TP53_S15 and RPS6KA1\n", + "looking for paths in the network with length: 7 for node TP53_S15 and RPS6KA1\n", + "looking for paths in the network with length: 8 for node TP53_S15 and RPS6KA1\n", + "looking for paths in the network with length: 9 for node TP53_S15 and RPS6KA1\n", + "looking for paths in the network with length: 10 for node TP53_S15 and RPS6KA1\n", + "i_search = 4\n", + "Looking for paths with length: 0 for node TP53_S15 and RPS6KA1\n", + "i_search = 4\n", + "Looking for paths with length: 1 for node TP53_S15 and RPS6KA1\n", + "i_search = 4\n", + "Looking for paths with length: 2 for node TP53_S15 and RPS6KA1\n", + "i_search = 4\n", + "Looking for paths with length: 3 for node TP53_S15 and RPS6KA1\n", + "i_search = 4\n", + "Looking for paths with length: 4 for node TP53_S15 and RPS6KA1\n", + "looking for paths in the network with length: 0 for node TP53_S15 and CREB1\n", + "looking for paths in the network with length: 1 for node TP53_S15 and CREB1\n", + "looking for paths in the network with length: 2 for node TP53_S15 and CREB1\n", + "looking for paths in the network with length: 3 for node TP53_S15 and CREB1\n", + "looking for paths in the network with length: 4 for node TP53_S15 and CREB1\n", + "looking for paths in the network with length: 5 for node TP53_S15 and CREB1\n", + "looking for paths in the network with length: 6 for node TP53_S15 and CREB1\n", + "looking for paths in the network with length: 7 for node TP53_S15 and CREB1\n", + "looking for paths in the network with length: 8 for node TP53_S15 and CREB1\n", + "looking for paths in the network with length: 9 for node TP53_S15 and CREB1\n", + "looking for paths in the network with length: 10 for node TP53_S15 and CREB1\n", + "i_search = 4\n", + "Looking for paths with length: 0 for node TP53_S15 and CREB1\n", + "i_search = 4\n", + "Looking for paths with length: 1 for node TP53_S15 and CREB1\n", + "i_search = 4\n", + "Looking for paths with length: 2 for node TP53_S15 and CREB1\n", + "i_search = 4\n", + "Looking for paths with length: 3 for node TP53_S15 and CREB1\n", + "i_search = 4\n", + "Looking for paths with length: 4 for node TP53_S15 and CREB1\n", + "looking for paths in the network with length: 0 for node TP53_S15 and NFKBIA\n", + "looking for paths in the network with length: 1 for node TP53_S15 and NFKBIA\n", + "looking for paths in the network with length: 2 for node TP53_S15 and NFKBIA\n", + "looking for paths in the network with length: 3 for node TP53_S15 and NFKBIA\n", + "looking for paths in the network with length: 4 for node TP53_S15 and NFKBIA\n", + "looking for paths in the network with length: 5 for node TP53_S15 and NFKBIA\n", + "looking for paths in the network with length: 6 for node TP53_S15 and NFKBIA\n", + "looking for paths in the network with length: 7 for node TP53_S15 and NFKBIA\n", + "looking for paths in the network with length: 8 for node TP53_S15 and NFKBIA\n", + "looking for paths in the network with length: 9 for node TP53_S15 and NFKBIA\n", + "looking for paths in the network with length: 10 for node TP53_S15 and NFKBIA\n", + "i_search = 4\n", + "Looking for paths with length: 0 for node TP53_S15 and NFKBIA\n", + "i_search = 4\n", + "Looking for paths with length: 1 for node TP53_S15 and NFKBIA\n", + "i_search = 4\n", + "Looking for paths with length: 2 for node TP53_S15 and NFKBIA\n", + "i_search = 4\n", + "Looking for paths with length: 3 for node TP53_S15 and NFKBIA\n", + "i_search = 4\n", + "Looking for paths with length: 4 for node TP53_S15 and NFKBIA\n", + "looking for paths in the network with length: 0 for node TP53_S15 and MTOR\n", + "looking for paths in the network with length: 1 for node TP53_S15 and MTOR\n", + "looking for paths in the network with length: 2 for node TP53_S15 and MTOR\n", + "looking for paths in the network with length: 3 for node TP53_S15 and MTOR\n", + "looking for paths in the network with length: 4 for node TP53_S15 and MTOR\n", + "looking for paths in the network with length: 5 for node TP53_S15 and MTOR\n", + "looking for paths in the network with length: 6 for node TP53_S15 and MTOR\n", + "looking for paths in the network with length: 7 for node TP53_S15 and MTOR\n", + "looking for paths in the network with length: 8 for node TP53_S15 and MTOR\n", + "looking for paths in the network with length: 9 for node TP53_S15 and MTOR\n", + "looking for paths in the network with length: 10 for node TP53_S15 and MTOR\n", + "i_search = 4\n", + "Looking for paths with length: 0 for node TP53_S15 and MTOR\n", + "i_search = 4\n", + "Looking for paths with length: 1 for node TP53_S15 and MTOR\n", + "i_search = 4\n", + "Looking for paths with length: 2 for node TP53_S15 and MTOR\n", + "i_search = 4\n", + "Looking for paths with length: 3 for node TP53_S15 and MTOR\n", + "i_search = 4\n", + "Looking for paths with length: 4 for node TP53_S15 and MTOR\n", + "looking for paths in the network with length: 0 for node TP53_S15 and JUN\n", + "looking for paths in the network with length: 1 for node TP53_S15 and JUN\n", + "looking for paths in the network with length: 2 for node TP53_S15 and JUN\n", + "looking for paths in the network with length: 3 for node TP53_S15 and JUN\n", + "looking for paths in the network with length: 4 for node TP53_S15 and JUN\n", + "looking for paths in the network with length: 5 for node TP53_S15 and JUN\n", + "looking for paths in the network with length: 6 for node TP53_S15 and JUN\n", + "looking for paths in the network with length: 7 for node TP53_S15 and JUN\n", + "looking for paths in the network with length: 8 for node TP53_S15 and JUN\n", + "looking for paths in the network with length: 9 for node TP53_S15 and JUN\n", + "looking for paths in the network with length: 10 for node TP53_S15 and JUN\n", + "i_search = 4\n", + "Looking for paths with length: 0 for node TP53_S15 and JUN\n", + "i_search = 4\n", + "Looking for paths with length: 1 for node TP53_S15 and JUN\n", + "i_search = 4\n", + "Looking for paths with length: 2 for node TP53_S15 and JUN\n", + "i_search = 4\n", + "Looking for paths with length: 3 for node TP53_S15 and JUN\n", + "i_search = 4\n", + "Looking for paths with length: 4 for node TP53_S15 and JUN\n", + "looking for paths in the network with length: 0 for node TP53_S15 and EGFR\n", + "looking for paths in the network with length: 1 for node TP53_S15 and EGFR\n", + "looking for paths in the network with length: 2 for node TP53_S15 and EGFR\n", + "looking for paths in the network with length: 3 for node TP53_S15 and EGFR\n", + "looking for paths in the network with length: 4 for node TP53_S15 and EGFR\n", + "looking for paths in the network with length: 5 for node TP53_S15 and EGFR\n", + "looking for paths in the network with length: 6 for node TP53_S15 and EGFR\n", + "looking for paths in the network with length: 7 for node TP53_S15 and EGFR\n", + "looking for paths in the network with length: 8 for node TP53_S15 and EGFR\n", + "looking for paths in the network with length: 9 for node TP53_S15 and EGFR\n", + "looking for paths in the network with length: 10 for node TP53_S15 and EGFR\n", + "i_search = 4\n", + "Looking for paths with length: 0 for node TP53_S15 and EGFR\n", + "i_search = 4\n", + "Looking for paths with length: 1 for node TP53_S15 and EGFR\n", + "i_search = 4\n", + "Looking for paths with length: 2 for node TP53_S15 and EGFR\n", + "i_search = 4\n", + "Looking for paths with length: 3 for node TP53_S15 and EGFR\n", + "i_search = 4\n", + "Looking for paths with length: 4 for node TP53_S15 and EGFR\n", + "looking for paths in the network with length: 0 for node TP53_S15 and MAPK3\n", + "looking for paths in the network with length: 1 for node TP53_S15 and MAPK3\n", + "looking for paths in the network with length: 2 for node TP53_S15 and MAPK3\n", + "looking for paths in the network with length: 3 for node TP53_S15 and MAPK3\n", + "looking for paths in the network with length: 4 for node TP53_S15 and MAPK3\n", + "looking for paths in the network with length: 5 for node TP53_S15 and MAPK3\n", + "looking for paths in the network with length: 6 for node TP53_S15 and MAPK3\n", + "looking for paths in the network with length: 7 for node TP53_S15 and MAPK3\n", + "looking for paths in the network with length: 8 for node TP53_S15 and MAPK3\n", + "looking for paths in the network with length: 9 for node TP53_S15 and MAPK3\n", + "looking for paths in the network with length: 10 for node TP53_S15 and MAPK3\n", + "i_search = 4\n", + "Looking for paths with length: 0 for node TP53_S15 and MAPK3\n", + "i_search = 4\n", + "Looking for paths with length: 1 for node TP53_S15 and MAPK3\n", + "i_search = 4\n", + "Looking for paths with length: 2 for node TP53_S15 and MAPK3\n", + "i_search = 4\n", + "Looking for paths with length: 3 for node TP53_S15 and MAPK3\n", + "i_search = 4\n", + "Looking for paths with length: 4 for node TP53_S15 and MAPK3\n", + "looking for paths in the network with length: 0 for node TP53_S15 and PTPN11\n", + "looking for paths in the network with length: 1 for node TP53_S15 and PTPN11\n", + "looking for paths in the network with length: 2 for node TP53_S15 and PTPN11\n", + "looking for paths in the network with length: 3 for node TP53_S15 and PTPN11\n", + "looking for paths in the network with length: 4 for node TP53_S15 and PTPN11\n", + "looking for paths in the network with length: 5 for node TP53_S15 and PTPN11\n", + "looking for paths in the network with length: 6 for node TP53_S15 and PTPN11\n", + "looking for paths in the network with length: 7 for node TP53_S15 and PTPN11\n", + "looking for paths in the network with length: 8 for node TP53_S15 and PTPN11\n", + "looking for paths in the network with length: 9 for node TP53_S15 and PTPN11\n", + "looking for paths in the network with length: 10 for node TP53_S15 and PTPN11\n", + "i_search = 4\n", + "Looking for paths with length: 0 for node TP53_S15 and PTPN11\n", + "i_search = 4\n", + "Looking for paths with length: 1 for node TP53_S15 and PTPN11\n", + "i_search = 4\n", + "Looking for paths with length: 2 for node TP53_S15 and PTPN11\n", + "i_search = 4\n", + "Looking for paths with length: 3 for node TP53_S15 and PTPN11\n", + "i_search = 4\n", + "Looking for paths with length: 4 for node TP53_S15 and PTPN11\n", + "looking for paths in the network with length: 0 for node TP53_S15 and STAT3\n", + "looking for paths in the network with length: 1 for node TP53_S15 and STAT3\n", + "looking for paths in the network with length: 2 for node TP53_S15 and STAT3\n", + "looking for paths in the network with length: 3 for node TP53_S15 and STAT3\n", + "looking for paths in the network with length: 4 for node TP53_S15 and STAT3\n", + "looking for paths in the network with length: 5 for node TP53_S15 and STAT3\n", + "looking for paths in the network with length: 6 for node TP53_S15 and STAT3\n", + "looking for paths in the network with length: 7 for node TP53_S15 and STAT3\n", + "looking for paths in the network with length: 8 for node TP53_S15 and STAT3\n", + "looking for paths in the network with length: 9 for node TP53_S15 and STAT3\n", + "looking for paths in the network with length: 10 for node TP53_S15 and STAT3\n", + "i_search = 4\n", + "Looking for paths with length: 0 for node TP53_S15 and STAT3\n", + "i_search = 4\n", + "Looking for paths with length: 1 for node TP53_S15 and STAT3\n", + "i_search = 4\n", + "Looking for paths with length: 2 for node TP53_S15 and STAT3\n", + "i_search = 4\n", + "Looking for paths with length: 3 for node TP53_S15 and STAT3\n", + "i_search = 4\n", + "Looking for paths with length: 4 for node TP53_S15 and STAT3\n", + "looking for paths in the network with length: 0 for node TP53_S15 and CHEK2\n", + "looking for paths in the network with length: 1 for node TP53_S15 and CHEK2\n", + "looking for paths in the network with length: 2 for node TP53_S15 and CHEK2\n", + "looking for paths in the network with length: 3 for node TP53_S15 and CHEK2\n", + "looking for paths in the network with length: 4 for node TP53_S15 and CHEK2\n", + "looking for paths in the network with length: 5 for node TP53_S15 and CHEK2\n", + "looking for paths in the network with length: 6 for node TP53_S15 and CHEK2\n", + "looking for paths in the network with length: 7 for node TP53_S15 and CHEK2\n", + "looking for paths in the network with length: 8 for node TP53_S15 and CHEK2\n", + "looking for paths in the network with length: 9 for node TP53_S15 and CHEK2\n", + "looking for paths in the network with length: 10 for node TP53_S15 and CHEK2\n", + "i_search = 4\n", + "Looking for paths with length: 0 for node TP53_S15 and CHEK2\n", + "i_search = 4\n", + "Looking for paths with length: 1 for node TP53_S15 and CHEK2\n", + "i_search = 4\n", + "Looking for paths with length: 2 for node TP53_S15 and CHEK2\n", + "i_search = 4\n", + "Looking for paths with length: 3 for node TP53_S15 and CHEK2\n", + "i_search = 4\n", + "Looking for paths with length: 4 for node TP53_S15 and CHEK2\n", + "looking for paths in the network with length: 0 for node TP53_S15 and RELA\n", + "looking for paths in the network with length: 1 for node TP53_S15 and RELA\n", + "looking for paths in the network with length: 2 for node TP53_S15 and RELA\n", + "looking for paths in the network with length: 3 for node TP53_S15 and RELA\n", + "looking for paths in the network with length: 4 for node TP53_S15 and RELA\n", + "looking for paths in the network with length: 5 for node TP53_S15 and RELA\n", + "looking for paths in the network with length: 6 for node TP53_S15 and RELA\n", + "looking for paths in the network with length: 7 for node TP53_S15 and RELA\n", + "looking for paths in the network with length: 8 for node TP53_S15 and RELA\n", + "looking for paths in the network with length: 9 for node TP53_S15 and RELA\n", + "looking for paths in the network with length: 10 for node TP53_S15 and RELA\n", + "i_search = 4\n", + "Looking for paths with length: 0 for node TP53_S15 and RELA\n", + "i_search = 4\n", + "Looking for paths with length: 1 for node TP53_S15 and RELA\n", + "i_search = 4\n", + "Looking for paths with length: 2 for node TP53_S15 and RELA\n", + "i_search = 4\n", + "Looking for paths with length: 3 for node TP53_S15 and RELA\n", + "i_search = 4\n", + "Looking for paths with length: 4 for node TP53_S15 and RELA\n", + "looking for paths in the network with length: 0 for node TP53_S15 and MARCKS\n", + "looking for paths in the network with length: 1 for node TP53_S15 and MARCKS\n", + "looking for paths in the network with length: 2 for node TP53_S15 and MARCKS\n", + "looking for paths in the network with length: 3 for node TP53_S15 and MARCKS\n", + "looking for paths in the network with length: 4 for node TP53_S15 and MARCKS\n", + "looking for paths in the network with length: 5 for node TP53_S15 and MARCKS\n", + "looking for paths in the network with length: 6 for node TP53_S15 and MARCKS\n", + "looking for paths in the network with length: 7 for node TP53_S15 and MARCKS\n", + "looking for paths in the network with length: 8 for node TP53_S15 and MARCKS\n", + "looking for paths in the network with length: 9 for node TP53_S15 and MARCKS\n", + "looking for paths in the network with length: 10 for node TP53_S15 and MARCKS\n", + "i_search = 4\n", + "Looking for paths with length: 0 for node TP53_S15 and MARCKS\n", + "i_search = 4\n", + "Looking for paths with length: 1 for node TP53_S15 and MARCKS\n", + "i_search = 4\n", + "Looking for paths with length: 2 for node TP53_S15 and MARCKS\n", + "i_search = 4\n", + "Looking for paths with length: 3 for node TP53_S15 and MARCKS\n", + "i_search = 4\n", + "Looking for paths with length: 4 for node TP53_S15 and MARCKS\n", + "looking for paths in the network with length: 0 for node AKT1S1_T246 and GSK3B_S9\n", + "looking for paths in the network with length: 1 for node AKT1S1_T246 and GSK3B_S9\n", + "looking for paths in the network with length: 2 for node AKT1S1_T246 and GSK3B_S9\n", + "looking for paths in the network with length: 3 for node AKT1S1_T246 and GSK3B_S9\n", + "looking for paths in the network with length: 4 for node AKT1S1_T246 and GSK3B_S9\n", + "looking for paths in the network with length: 5 for node AKT1S1_T246 and GSK3B_S9\n", + "looking for paths in the network with length: 6 for node AKT1S1_T246 and GSK3B_S9\n", + "looking for paths in the network with length: 7 for node AKT1S1_T246 and GSK3B_S9\n", + "looking for paths in the network with length: 8 for node AKT1S1_T246 and GSK3B_S9\n", + "looking for paths in the network with length: 9 for node AKT1S1_T246 and GSK3B_S9\n", + "looking for paths in the network with length: 10 for node AKT1S1_T246 and GSK3B_S9\n", + "i_search = 4\n", + "Looking for paths with length: 0 for node AKT1S1_T246 and GSK3B_S9\n", + "i_search = 4\n", + "Looking for paths with length: 1 for node AKT1S1_T246 and GSK3B_S9\n", + "i_search = 4\n", + "Looking for paths with length: 2 for node AKT1S1_T246 and GSK3B_S9\n", + "i_search = 4\n", + "Looking for paths with length: 3 for node AKT1S1_T246 and GSK3B_S9\n", + "i_search = 4\n", + "Looking for paths with length: 4 for node AKT1S1_T246 and GSK3B_S9\n", + "looking for paths in the network with length: 0 for node AKT1S1_T246 and GSK3B_S21\n", + "looking for paths in the network with length: 1 for node AKT1S1_T246 and GSK3B_S21\n", + "looking for paths in the network with length: 2 for node AKT1S1_T246 and GSK3B_S21\n", + "looking for paths in the network with length: 3 for node AKT1S1_T246 and GSK3B_S21\n", + "looking for paths in the network with length: 4 for node AKT1S1_T246 and GSK3B_S21\n", + "looking for paths in the network with length: 5 for node AKT1S1_T246 and GSK3B_S21\n", + "looking for paths in the network with length: 6 for node AKT1S1_T246 and GSK3B_S21\n", + "looking for paths in the network with length: 7 for node AKT1S1_T246 and GSK3B_S21\n", + "looking for paths in the network with length: 8 for node AKT1S1_T246 and GSK3B_S21\n", + "looking for paths in the network with length: 9 for node AKT1S1_T246 and GSK3B_S21\n", + "looking for paths in the network with length: 10 for node AKT1S1_T246 and GSK3B_S21\n", + "i_search = 4\n", + "Looking for paths with length: 0 for node AKT1S1_T246 and GSK3B_S21\n", + "i_search = 4\n", + "Looking for paths with length: 1 for node AKT1S1_T246 and GSK3B_S21\n", + "i_search = 4\n", + "Looking for paths with length: 2 for node AKT1S1_T246 and GSK3B_S21\n", + "i_search = 4\n", + "Looking for paths with length: 3 for node AKT1S1_T246 and GSK3B_S21\n", + "i_search = 4\n", + "Looking for paths with length: 4 for node AKT1S1_T246 and GSK3B_S21\n", + "looking for paths in the network with length: 0 for node AKT1S1_T246 and AKT1_S473\n", + "looking for paths in the network with length: 1 for node AKT1S1_T246 and AKT1_S473\n", + "looking for paths in the network with length: 2 for node AKT1S1_T246 and AKT1_S473\n", + "looking for paths in the network with length: 3 for node AKT1S1_T246 and AKT1_S473\n", + "looking for paths in the network with length: 4 for node AKT1S1_T246 and AKT1_S473\n", + "looking for paths in the network with length: 5 for node AKT1S1_T246 and AKT1_S473\n", + "looking for paths in the network with length: 6 for node AKT1S1_T246 and AKT1_S473\n", + "looking for paths in the network with length: 7 for node AKT1S1_T246 and AKT1_S473\n", + "looking for paths in the network with length: 8 for node AKT1S1_T246 and AKT1_S473\n", + "looking for paths in the network with length: 9 for node AKT1S1_T246 and AKT1_S473\n", + "looking for paths in the network with length: 10 for node AKT1S1_T246 and AKT1_S473\n", + "i_search = 4\n", + "Looking for paths with length: 0 for node AKT1S1_T246 and AKT1_S473\n", + "i_search = 4\n", + "Looking for paths with length: 1 for node AKT1S1_T246 and AKT1_S473\n", + "i_search = 4\n", + "Looking for paths with length: 2 for node AKT1S1_T246 and AKT1_S473\n", + "[['AKT1S1_T246', 'AKT1', 'AKT1_S473']]\n", + "AKT1 AKT1S1_T246\n", + "AKT1_S473 AKT1\n", + "looking for paths in the network with length: 0 for node AKT1S1_T246 and HSPB1_S78\n", + "looking for paths in the network with length: 1 for node AKT1S1_T246 and HSPB1_S78\n", + "looking for paths in the network with length: 2 for node AKT1S1_T246 and HSPB1_S78\n", + "looking for paths in the network with length: 3 for node AKT1S1_T246 and HSPB1_S78\n", + "looking for paths in the network with length: 4 for node AKT1S1_T246 and HSPB1_S78\n", + "looking for paths in the network with length: 5 for node AKT1S1_T246 and HSPB1_S78\n", + "looking for paths in the network with length: 6 for node AKT1S1_T246 and HSPB1_S78\n", + "looking for paths in the network with length: 7 for node AKT1S1_T246 and HSPB1_S78\n", + "looking for paths in the network with length: 8 for node AKT1S1_T246 and HSPB1_S78\n", + "looking for paths in the network with length: 9 for node AKT1S1_T246 and HSPB1_S78\n", + "looking for paths in the network with length: 10 for node AKT1S1_T246 and HSPB1_S78\n", + "i_search = 4\n", + "Looking for paths with length: 0 for node AKT1S1_T246 and HSPB1_S78\n", + "i_search = 4\n", + "Looking for paths with length: 1 for node AKT1S1_T246 and HSPB1_S78\n", + "i_search = 4\n", + "Looking for paths with length: 2 for node AKT1S1_T246 and HSPB1_S78\n", + "i_search = 4\n", + "Looking for paths with length: 3 for node AKT1S1_T246 and HSPB1_S78\n", + "i_search = 4\n", + "Looking for paths with length: 4 for node AKT1S1_T246 and HSPB1_S78\n", + "looking for paths in the network with length: 0 for node AKT1S1_T246 and HSPB1_S82\n", + "looking for paths in the network with length: 1 for node AKT1S1_T246 and HSPB1_S82\n", + "looking for paths in the network with length: 2 for node AKT1S1_T246 and HSPB1_S82\n", + "looking for paths in the network with length: 3 for node AKT1S1_T246 and HSPB1_S82\n", + "looking for paths in the network with length: 4 for node AKT1S1_T246 and HSPB1_S82\n", + "looking for paths in the network with length: 5 for node AKT1S1_T246 and HSPB1_S82\n", + "looking for paths in the network with length: 6 for node AKT1S1_T246 and HSPB1_S82\n", + "looking for paths in the network with length: 7 for node AKT1S1_T246 and HSPB1_S82\n", + "looking for paths in the network with length: 8 for node AKT1S1_T246 and HSPB1_S82\n", + "looking for paths in the network with length: 9 for node AKT1S1_T246 and HSPB1_S82\n", + "looking for paths in the network with length: 10 for node AKT1S1_T246 and HSPB1_S82\n", + "i_search = 4\n", + "Looking for paths with length: 0 for node AKT1S1_T246 and HSPB1_S82\n", + "i_search = 4\n", + "Looking for paths with length: 1 for node AKT1S1_T246 and HSPB1_S82\n", + "i_search = 4\n", + "Looking for paths with length: 2 for node AKT1S1_T246 and HSPB1_S82\n", + "i_search = 4\n", + "Looking for paths with length: 3 for node AKT1S1_T246 and HSPB1_S82\n", + "i_search = 4\n", + "Looking for paths with length: 4 for node AKT1S1_T246 and HSPB1_S82\n", + "looking for paths in the network with length: 0 for node AKT1S1_T246 and MAPK14_T180\n", + "looking for paths in the network with length: 1 for node AKT1S1_T246 and MAPK14_T180\n", + "looking for paths in the network with length: 2 for node AKT1S1_T246 and MAPK14_T180\n", + "looking for paths in the network with length: 3 for node AKT1S1_T246 and MAPK14_T180\n", + "looking for paths in the network with length: 4 for node AKT1S1_T246 and MAPK14_T180\n", + "looking for paths in the network with length: 5 for node AKT1S1_T246 and MAPK14_T180\n", + "looking for paths in the network with length: 6 for node AKT1S1_T246 and MAPK14_T180\n", + "looking for paths in the network with length: 7 for node AKT1S1_T246 and MAPK14_T180\n", + "looking for paths in the network with length: 8 for node AKT1S1_T246 and MAPK14_T180\n", + "looking for paths in the network with length: 9 for node AKT1S1_T246 and MAPK14_T180\n", + "looking for paths in the network with length: 10 for node AKT1S1_T246 and MAPK14_T180\n", + "i_search = 4\n", + "Looking for paths with length: 0 for node AKT1S1_T246 and MAPK14_T180\n", + "i_search = 4\n", + "Looking for paths with length: 1 for node AKT1S1_T246 and MAPK14_T180\n", + "i_search = 4\n", + "Looking for paths with length: 2 for node AKT1S1_T246 and MAPK14_T180\n", + "i_search = 4\n", + "Looking for paths with length: 3 for node AKT1S1_T246 and MAPK14_T180\n", + "i_search = 4\n", + "Looking for paths with length: 4 for node AKT1S1_T246 and MAPK14_T180\n", + "looking for paths in the network with length: 0 for node AKT1S1_T246 and MAPK14_Y182\n", + "looking for paths in the network with length: 1 for node AKT1S1_T246 and MAPK14_Y182\n", + "looking for paths in the network with length: 2 for node AKT1S1_T246 and MAPK14_Y182\n", + "looking for paths in the network with length: 3 for node AKT1S1_T246 and MAPK14_Y182\n", + "looking for paths in the network with length: 4 for node AKT1S1_T246 and MAPK14_Y182\n", + "looking for paths in the network with length: 5 for node AKT1S1_T246 and MAPK14_Y182\n", + "looking for paths in the network with length: 6 for node AKT1S1_T246 and MAPK14_Y182\n", + "looking for paths in the network with length: 7 for node AKT1S1_T246 and MAPK14_Y182\n", + "looking for paths in the network with length: 8 for node AKT1S1_T246 and MAPK14_Y182\n", + "looking for paths in the network with length: 9 for node AKT1S1_T246 and MAPK14_Y182\n", + "looking for paths in the network with length: 10 for node AKT1S1_T246 and MAPK14_Y182\n", + "i_search = 4\n", + "Looking for paths with length: 0 for node AKT1S1_T246 and MAPK14_Y182\n", + "i_search = 4\n", + "Looking for paths with length: 1 for node AKT1S1_T246 and MAPK14_Y182\n", + "i_search = 4\n", + "Looking for paths with length: 2 for node AKT1S1_T246 and MAPK14_Y182\n", + "i_search = 4\n", + "Looking for paths with length: 3 for node AKT1S1_T246 and MAPK14_Y182\n", + "i_search = 4\n", + "Looking for paths with length: 4 for node AKT1S1_T246 and MAPK14_Y182\n", + "looking for paths in the network with length: 0 for node AKT1S1_T246 and MAP2K1_S218\n", + "looking for paths in the network with length: 1 for node AKT1S1_T246 and MAP2K1_S218\n", + "looking for paths in the network with length: 2 for node AKT1S1_T246 and MAP2K1_S218\n", + "looking for paths in the network with length: 3 for node AKT1S1_T246 and MAP2K1_S218\n", + "looking for paths in the network with length: 4 for node AKT1S1_T246 and MAP2K1_S218\n", + "looking for paths in the network with length: 5 for node AKT1S1_T246 and MAP2K1_S218\n", + "looking for paths in the network with length: 6 for node AKT1S1_T246 and MAP2K1_S218\n", + "looking for paths in the network with length: 7 for node AKT1S1_T246 and MAP2K1_S218\n", + "looking for paths in the network with length: 8 for node AKT1S1_T246 and MAP2K1_S218\n", + "looking for paths in the network with length: 9 for node AKT1S1_T246 and MAP2K1_S218\n", + "looking for paths in the network with length: 10 for node AKT1S1_T246 and MAP2K1_S218\n", + "i_search = 4\n", + "Looking for paths with length: 0 for node AKT1S1_T246 and MAP2K1_S218\n", + "i_search = 4\n", + "Looking for paths with length: 1 for node AKT1S1_T246 and MAP2K1_S218\n", + "i_search = 4\n", + "Looking for paths with length: 2 for node AKT1S1_T246 and MAP2K1_S218\n", + "i_search = 4\n", + "Looking for paths with length: 3 for node AKT1S1_T246 and MAP2K1_S218\n", + "i_search = 4\n", + "Looking for paths with length: 4 for node AKT1S1_T246 and MAP2K1_S218\n", + "looking for paths in the network with length: 0 for node AKT1S1_T246 and MAP2K1_S222\n", + "looking for paths in the network with length: 1 for node AKT1S1_T246 and MAP2K1_S222\n", + "looking for paths in the network with length: 2 for node AKT1S1_T246 and MAP2K1_S222\n", + "looking for paths in the network with length: 3 for node AKT1S1_T246 and MAP2K1_S222\n", + "looking for paths in the network with length: 4 for node AKT1S1_T246 and MAP2K1_S222\n", + "looking for paths in the network with length: 5 for node AKT1S1_T246 and MAP2K1_S222\n", + "looking for paths in the network with length: 6 for node AKT1S1_T246 and MAP2K1_S222\n", + "looking for paths in the network with length: 7 for node AKT1S1_T246 and MAP2K1_S222\n", + "looking for paths in the network with length: 8 for node AKT1S1_T246 and MAP2K1_S222\n", + "looking for paths in the network with length: 9 for node AKT1S1_T246 and MAP2K1_S222\n", + "looking for paths in the network with length: 10 for node AKT1S1_T246 and MAP2K1_S222\n", + "i_search = 4\n", + "Looking for paths with length: 0 for node AKT1S1_T246 and MAP2K1_S222\n", + "i_search = 4\n", + "Looking for paths with length: 1 for node AKT1S1_T246 and MAP2K1_S222\n", + "i_search = 4\n", + "Looking for paths with length: 2 for node AKT1S1_T246 and MAP2K1_S222\n", + "i_search = 4\n", + "Looking for paths with length: 3 for node AKT1S1_T246 and MAP2K1_S222\n", + "i_search = 4\n", + "Looking for paths with length: 4 for node AKT1S1_T246 and MAP2K1_S222\n", + "looking for paths in the network with length: 0 for node AKT1S1_T246 and RPS6KA1_S380\n", + "looking for paths in the network with length: 1 for node AKT1S1_T246 and RPS6KA1_S380\n", + "looking for paths in the network with length: 2 for node AKT1S1_T246 and RPS6KA1_S380\n", + "looking for paths in the network with length: 3 for node AKT1S1_T246 and RPS6KA1_S380\n", + "looking for paths in the network with length: 4 for node AKT1S1_T246 and RPS6KA1_S380\n", + "looking for paths in the network with length: 5 for node AKT1S1_T246 and RPS6KA1_S380\n", + "looking for paths in the network with length: 6 for node AKT1S1_T246 and RPS6KA1_S380\n", + "looking for paths in the network with length: 7 for node AKT1S1_T246 and RPS6KA1_S380\n", + "looking for paths in the network with length: 8 for node AKT1S1_T246 and RPS6KA1_S380\n", + "looking for paths in the network with length: 9 for node AKT1S1_T246 and RPS6KA1_S380\n", + "looking for paths in the network with length: 10 for node AKT1S1_T246 and RPS6KA1_S380\n", + "i_search = 4\n", + "Looking for paths with length: 0 for node AKT1S1_T246 and RPS6KA1_S380\n", + "i_search = 4\n", + "Looking for paths with length: 1 for node AKT1S1_T246 and RPS6KA1_S380\n", + "i_search = 4\n", + "Looking for paths with length: 2 for node AKT1S1_T246 and RPS6KA1_S380\n", + "i_search = 4\n", + "Looking for paths with length: 3 for node AKT1S1_T246 and RPS6KA1_S380\n", + "i_search = 4\n", + "Looking for paths with length: 4 for node AKT1S1_T246 and RPS6KA1_S380\n", + "looking for paths in the network with length: 0 for node AKT1S1_T246 and CREB1_S133\n", + "looking for paths in the network with length: 1 for node AKT1S1_T246 and CREB1_S133\n", + "looking for paths in the network with length: 2 for node AKT1S1_T246 and CREB1_S133\n", + "looking for paths in the network with length: 3 for node AKT1S1_T246 and CREB1_S133\n", + "looking for paths in the network with length: 4 for node AKT1S1_T246 and CREB1_S133\n", + "looking for paths in the network with length: 5 for node AKT1S1_T246 and CREB1_S133\n", + "looking for paths in the network with length: 6 for node AKT1S1_T246 and CREB1_S133\n", + "looking for paths in the network with length: 7 for node AKT1S1_T246 and CREB1_S133\n", + "looking for paths in the network with length: 8 for node AKT1S1_T246 and CREB1_S133\n", + "looking for paths in the network with length: 9 for node AKT1S1_T246 and CREB1_S133\n", + "looking for paths in the network with length: 10 for node AKT1S1_T246 and CREB1_S133\n", + "i_search = 4\n", + "Looking for paths with length: 0 for node AKT1S1_T246 and CREB1_S133\n", + "i_search = 4\n", + "Looking for paths with length: 1 for node AKT1S1_T246 and CREB1_S133\n", + "i_search = 4\n", + "Looking for paths with length: 2 for node AKT1S1_T246 and CREB1_S133\n", + "i_search = 4\n", + "Looking for paths with length: 3 for node AKT1S1_T246 and CREB1_S133\n", + "i_search = 4\n", + "Looking for paths with length: 4 for node AKT1S1_T246 and CREB1_S133\n", + "looking for paths in the network with length: 0 for node AKT1S1_T246 and NFKBIA_S32\n", + "looking for paths in the network with length: 1 for node AKT1S1_T246 and NFKBIA_S32\n", + "looking for paths in the network with length: 2 for node AKT1S1_T246 and NFKBIA_S32\n", + "looking for paths in the network with length: 3 for node AKT1S1_T246 and NFKBIA_S32\n", + "looking for paths in the network with length: 4 for node AKT1S1_T246 and NFKBIA_S32\n", + "looking for paths in the network with length: 5 for node AKT1S1_T246 and NFKBIA_S32\n", + "looking for paths in the network with length: 6 for node AKT1S1_T246 and NFKBIA_S32\n", + "looking for paths in the network with length: 7 for node AKT1S1_T246 and NFKBIA_S32\n", + "looking for paths in the network with length: 8 for node AKT1S1_T246 and NFKBIA_S32\n", + "looking for paths in the network with length: 9 for node AKT1S1_T246 and NFKBIA_S32\n", + "looking for paths in the network with length: 10 for node AKT1S1_T246 and NFKBIA_S32\n", + "i_search = 4\n", + "Looking for paths with length: 0 for node AKT1S1_T246 and NFKBIA_S32\n", + "i_search = 4\n", + "Looking for paths with length: 1 for node AKT1S1_T246 and NFKBIA_S32\n", + "i_search = 4\n", + "Looking for paths with length: 2 for node AKT1S1_T246 and NFKBIA_S32\n", + "i_search = 4\n", + "Looking for paths with length: 3 for node AKT1S1_T246 and NFKBIA_S32\n", + "i_search = 4\n", + "Looking for paths with length: 4 for node AKT1S1_T246 and NFKBIA_S32\n", + "looking for paths in the network with length: 0 for node AKT1S1_T246 and NFKBIA_S36\n", + "looking for paths in the network with length: 1 for node AKT1S1_T246 and NFKBIA_S36\n", + "looking for paths in the network with length: 2 for node AKT1S1_T246 and NFKBIA_S36\n", + "looking for paths in the network with length: 3 for node AKT1S1_T246 and NFKBIA_S36\n", + "looking for paths in the network with length: 4 for node AKT1S1_T246 and NFKBIA_S36\n", + "looking for paths in the network with length: 5 for node AKT1S1_T246 and NFKBIA_S36\n", + "looking for paths in the network with length: 6 for node AKT1S1_T246 and NFKBIA_S36\n", + "looking for paths in the network with length: 7 for node AKT1S1_T246 and NFKBIA_S36\n", + "looking for paths in the network with length: 8 for node AKT1S1_T246 and NFKBIA_S36\n", + "looking for paths in the network with length: 9 for node AKT1S1_T246 and NFKBIA_S36\n", + "looking for paths in the network with length: 10 for node AKT1S1_T246 and NFKBIA_S36\n", + "i_search = 4\n", + "Looking for paths with length: 0 for node AKT1S1_T246 and NFKBIA_S36\n", + "i_search = 4\n", + "Looking for paths with length: 1 for node AKT1S1_T246 and NFKBIA_S36\n", + "i_search = 4\n", + "Looking for paths with length: 2 for node AKT1S1_T246 and NFKBIA_S36\n", + "i_search = 4\n", + "Looking for paths with length: 3 for node AKT1S1_T246 and NFKBIA_S36\n", + "i_search = 4\n", + "Looking for paths with length: 4 for node AKT1S1_T246 and NFKBIA_S36\n", + "looking for paths in the network with length: 0 for node AKT1S1_T246 and MTOR_S2448\n", + "looking for paths in the network with length: 1 for node AKT1S1_T246 and MTOR_S2448\n", + "looking for paths in the network with length: 2 for node AKT1S1_T246 and MTOR_S2448\n", + "looking for paths in the network with length: 3 for node AKT1S1_T246 and MTOR_S2448\n", + "looking for paths in the network with length: 4 for node AKT1S1_T246 and MTOR_S2448\n", + "looking for paths in the network with length: 5 for node AKT1S1_T246 and MTOR_S2448\n", + "looking for paths in the network with length: 6 for node AKT1S1_T246 and MTOR_S2448\n", + "looking for paths in the network with length: 7 for node AKT1S1_T246 and MTOR_S2448\n", + "looking for paths in the network with length: 8 for node AKT1S1_T246 and MTOR_S2448\n", + "looking for paths in the network with length: 9 for node AKT1S1_T246 and MTOR_S2448\n", + "looking for paths in the network with length: 10 for node AKT1S1_T246 and MTOR_S2448\n", + "i_search = 4\n", + "Looking for paths with length: 0 for node AKT1S1_T246 and MTOR_S2448\n", + "i_search = 4\n", + "Looking for paths with length: 1 for node AKT1S1_T246 and MTOR_S2448\n", + "i_search = 4\n", + "Looking for paths with length: 2 for node AKT1S1_T246 and MTOR_S2448\n", + "i_search = 4\n", + "Looking for paths with length: 3 for node AKT1S1_T246 and MTOR_S2448\n", + "i_search = 4\n", + "Looking for paths with length: 4 for node AKT1S1_T246 and MTOR_S2448\n", + "[['AKT1S1_T246', 'AKT1', 'AKT1_S473', 'MTOR', 'MTOR_S2448'], ['AKT1S1_T246', 'AKT1', 'AKT1_T450', 'MTOR', 'MTOR_S2448']]\n", + "AKT1 AKT1S1_T246\n", + "AKT1_S473 AKT1\n", + "MTOR AKT1_S473\n", + "MTOR MTOR_S2448\n", + "AKT1 AKT1S1_T246\n", + "AKT1_T450 AKT1\n", + "MTOR AKT1_T450\n", + "MTOR MTOR_S2448\n", + "looking for paths in the network with length: 0 for node AKT1S1_T246 and JUN_S63\n", + "looking for paths in the network with length: 1 for node AKT1S1_T246 and JUN_S63\n", + "looking for paths in the network with length: 2 for node AKT1S1_T246 and JUN_S63\n", + "looking for paths in the network with length: 3 for node AKT1S1_T246 and JUN_S63\n", + "looking for paths in the network with length: 4 for node AKT1S1_T246 and JUN_S63\n", + "looking for paths in the network with length: 5 for node AKT1S1_T246 and JUN_S63\n", + "looking for paths in the network with length: 6 for node AKT1S1_T246 and JUN_S63\n", + "looking for paths in the network with length: 7 for node AKT1S1_T246 and JUN_S63\n", + "looking for paths in the network with length: 8 for node AKT1S1_T246 and JUN_S63\n", + "looking for paths in the network with length: 9 for node AKT1S1_T246 and JUN_S63\n", + "looking for paths in the network with length: 10 for node AKT1S1_T246 and JUN_S63\n", + "i_search = 4\n", + "Looking for paths with length: 0 for node AKT1S1_T246 and JUN_S63\n", + "i_search = 4\n", + "Looking for paths with length: 1 for node AKT1S1_T246 and JUN_S63\n", + "i_search = 4\n", + "Looking for paths with length: 2 for node AKT1S1_T246 and JUN_S63\n", + "i_search = 4\n", + "Looking for paths with length: 3 for node AKT1S1_T246 and JUN_S63\n", + "i_search = 4\n", + "Looking for paths with length: 4 for node AKT1S1_T246 and JUN_S63\n", + "looking for paths in the network with length: 0 for node AKT1S1_T246 and EGFR_Y1068\n", + "looking for paths in the network with length: 1 for node AKT1S1_T246 and EGFR_Y1068\n", + "looking for paths in the network with length: 2 for node AKT1S1_T246 and EGFR_Y1068\n", + "looking for paths in the network with length: 3 for node AKT1S1_T246 and EGFR_Y1068\n", + "looking for paths in the network with length: 4 for node AKT1S1_T246 and EGFR_Y1068\n", + "looking for paths in the network with length: 5 for node AKT1S1_T246 and EGFR_Y1068\n", + "looking for paths in the network with length: 6 for node AKT1S1_T246 and EGFR_Y1068\n", + "looking for paths in the network with length: 7 for node AKT1S1_T246 and EGFR_Y1068\n", + "looking for paths in the network with length: 8 for node AKT1S1_T246 and EGFR_Y1068\n", + "looking for paths in the network with length: 9 for node AKT1S1_T246 and EGFR_Y1068\n", + "looking for paths in the network with length: 10 for node AKT1S1_T246 and EGFR_Y1068\n", + "i_search = 4\n", + "Looking for paths with length: 0 for node AKT1S1_T246 and EGFR_Y1068\n", + "i_search = 4\n", + "Looking for paths with length: 1 for node AKT1S1_T246 and EGFR_Y1068\n", + "i_search = 4\n", + "Looking for paths with length: 2 for node AKT1S1_T246 and EGFR_Y1068\n", + "i_search = 4\n", + "Looking for paths with length: 3 for node AKT1S1_T246 and EGFR_Y1068\n", + "i_search = 4\n", + "Looking for paths with length: 4 for node AKT1S1_T246 and EGFR_Y1068\n", + "looking for paths in the network with length: 0 for node AKT1S1_T246 and MAPK3_T202\n", + "looking for paths in the network with length: 1 for node AKT1S1_T246 and MAPK3_T202\n", + "looking for paths in the network with length: 2 for node AKT1S1_T246 and MAPK3_T202\n", + "looking for paths in the network with length: 3 for node AKT1S1_T246 and MAPK3_T202\n", + "looking for paths in the network with length: 4 for node AKT1S1_T246 and MAPK3_T202\n", + "looking for paths in the network with length: 5 for node AKT1S1_T246 and MAPK3_T202\n", + "looking for paths in the network with length: 6 for node AKT1S1_T246 and MAPK3_T202\n", + "looking for paths in the network with length: 7 for node AKT1S1_T246 and MAPK3_T202\n", + "looking for paths in the network with length: 8 for node AKT1S1_T246 and MAPK3_T202\n", + "looking for paths in the network with length: 9 for node AKT1S1_T246 and MAPK3_T202\n", + "looking for paths in the network with length: 10 for node AKT1S1_T246 and MAPK3_T202\n", + "i_search = 4\n", + "Looking for paths with length: 0 for node AKT1S1_T246 and MAPK3_T202\n", + "i_search = 4\n", + "Looking for paths with length: 1 for node AKT1S1_T246 and MAPK3_T202\n", + "i_search = 4\n", + "Looking for paths with length: 2 for node AKT1S1_T246 and MAPK3_T202\n", + "i_search = 4\n", + "Looking for paths with length: 3 for node AKT1S1_T246 and MAPK3_T202\n", + "i_search = 4\n", + "Looking for paths with length: 4 for node AKT1S1_T246 and MAPK3_T202\n", + "looking for paths in the network with length: 0 for node AKT1S1_T246 and MAPK3_Y204\n", + "looking for paths in the network with length: 1 for node AKT1S1_T246 and MAPK3_Y204\n", + "looking for paths in the network with length: 2 for node AKT1S1_T246 and MAPK3_Y204\n", + "looking for paths in the network with length: 3 for node AKT1S1_T246 and MAPK3_Y204\n", + "looking for paths in the network with length: 4 for node AKT1S1_T246 and MAPK3_Y204\n", + "looking for paths in the network with length: 5 for node AKT1S1_T246 and MAPK3_Y204\n", + "looking for paths in the network with length: 6 for node AKT1S1_T246 and MAPK3_Y204\n", + "looking for paths in the network with length: 7 for node AKT1S1_T246 and MAPK3_Y204\n", + "looking for paths in the network with length: 8 for node AKT1S1_T246 and MAPK3_Y204\n", + "looking for paths in the network with length: 9 for node AKT1S1_T246 and MAPK3_Y204\n", + "looking for paths in the network with length: 10 for node AKT1S1_T246 and MAPK3_Y204\n", + "i_search = 4\n", + "Looking for paths with length: 0 for node AKT1S1_T246 and MAPK3_Y204\n", + "i_search = 4\n", + "Looking for paths with length: 1 for node AKT1S1_T246 and MAPK3_Y204\n", + "i_search = 4\n", + "Looking for paths with length: 2 for node AKT1S1_T246 and MAPK3_Y204\n", + "i_search = 4\n", + "Looking for paths with length: 3 for node AKT1S1_T246 and MAPK3_Y204\n", + "i_search = 4\n", + "Looking for paths with length: 4 for node AKT1S1_T246 and MAPK3_Y204\n", + "looking for paths in the network with length: 0 for node AKT1S1_T246 and PTPN11_Y542\n", + "looking for paths in the network with length: 1 for node AKT1S1_T246 and PTPN11_Y542\n", + "looking for paths in the network with length: 2 for node AKT1S1_T246 and PTPN11_Y542\n", + "looking for paths in the network with length: 3 for node AKT1S1_T246 and PTPN11_Y542\n", + "looking for paths in the network with length: 4 for node AKT1S1_T246 and PTPN11_Y542\n", + "looking for paths in the network with length: 5 for node AKT1S1_T246 and PTPN11_Y542\n", + "looking for paths in the network with length: 6 for node AKT1S1_T246 and PTPN11_Y542\n", + "looking for paths in the network with length: 7 for node AKT1S1_T246 and PTPN11_Y542\n", + "looking for paths in the network with length: 8 for node AKT1S1_T246 and PTPN11_Y542\n", + "looking for paths in the network with length: 9 for node AKT1S1_T246 and PTPN11_Y542\n", + "looking for paths in the network with length: 10 for node AKT1S1_T246 and PTPN11_Y542\n", + "i_search = 4\n", + "Looking for paths with length: 0 for node AKT1S1_T246 and PTPN11_Y542\n", + "i_search = 4\n", + "Looking for paths with length: 1 for node AKT1S1_T246 and PTPN11_Y542\n", + "i_search = 4\n", + "Looking for paths with length: 2 for node AKT1S1_T246 and PTPN11_Y542\n", + "i_search = 4\n", + "Looking for paths with length: 3 for node AKT1S1_T246 and PTPN11_Y542\n", + "i_search = 4\n", + "Looking for paths with length: 4 for node AKT1S1_T246 and PTPN11_Y542\n", + "looking for paths in the network with length: 0 for node AKT1S1_T246 and STAT3_Y705\n", + "looking for paths in the network with length: 1 for node AKT1S1_T246 and STAT3_Y705\n", + "looking for paths in the network with length: 2 for node AKT1S1_T246 and STAT3_Y705\n", + "looking for paths in the network with length: 3 for node AKT1S1_T246 and STAT3_Y705\n", + "looking for paths in the network with length: 4 for node AKT1S1_T246 and STAT3_Y705\n", + "looking for paths in the network with length: 5 for node AKT1S1_T246 and STAT3_Y705\n", + "looking for paths in the network with length: 6 for node AKT1S1_T246 and STAT3_Y705\n", + "looking for paths in the network with length: 7 for node AKT1S1_T246 and STAT3_Y705\n", + "looking for paths in the network with length: 8 for node AKT1S1_T246 and STAT3_Y705\n", + "looking for paths in the network with length: 9 for node AKT1S1_T246 and STAT3_Y705\n", + "looking for paths in the network with length: 10 for node AKT1S1_T246 and STAT3_Y705\n", + "i_search = 4\n", + "Looking for paths with length: 0 for node AKT1S1_T246 and STAT3_Y705\n", + "i_search = 4\n", + "Looking for paths with length: 1 for node AKT1S1_T246 and STAT3_Y705\n", + "i_search = 4\n", + "Looking for paths with length: 2 for node AKT1S1_T246 and STAT3_Y705\n", + "i_search = 4\n", + "Looking for paths with length: 3 for node AKT1S1_T246 and STAT3_Y705\n", + "i_search = 4\n", + "Looking for paths with length: 4 for node AKT1S1_T246 and STAT3_Y705\n", + "looking for paths in the network with length: 0 for node AKT1S1_T246 and CHEK2_T68\n", + "looking for paths in the network with length: 1 for node AKT1S1_T246 and CHEK2_T68\n", + "looking for paths in the network with length: 2 for node AKT1S1_T246 and CHEK2_T68\n", + "looking for paths in the network with length: 3 for node AKT1S1_T246 and CHEK2_T68\n", + "looking for paths in the network with length: 4 for node AKT1S1_T246 and CHEK2_T68\n", + "looking for paths in the network with length: 5 for node AKT1S1_T246 and CHEK2_T68\n", + "looking for paths in the network with length: 6 for node AKT1S1_T246 and CHEK2_T68\n", + "looking for paths in the network with length: 7 for node AKT1S1_T246 and CHEK2_T68\n", + "looking for paths in the network with length: 8 for node AKT1S1_T246 and CHEK2_T68\n", + "looking for paths in the network with length: 9 for node AKT1S1_T246 and CHEK2_T68\n", + "looking for paths in the network with length: 10 for node AKT1S1_T246 and CHEK2_T68\n", + "i_search = 4\n", + "Looking for paths with length: 0 for node AKT1S1_T246 and CHEK2_T68\n", + "i_search = 4\n", + "Looking for paths with length: 1 for node AKT1S1_T246 and CHEK2_T68\n", + "i_search = 4\n", + "Looking for paths with length: 2 for node AKT1S1_T246 and CHEK2_T68\n", + "i_search = 4\n", + "Looking for paths with length: 3 for node AKT1S1_T246 and CHEK2_T68\n", + "i_search = 4\n", + "Looking for paths with length: 4 for node AKT1S1_T246 and CHEK2_T68\n", + "looking for paths in the network with length: 0 for node AKT1S1_T246 and RELA_S536\n", + "looking for paths in the network with length: 1 for node AKT1S1_T246 and RELA_S536\n", + "looking for paths in the network with length: 2 for node AKT1S1_T246 and RELA_S536\n", + "looking for paths in the network with length: 3 for node AKT1S1_T246 and RELA_S536\n", + "looking for paths in the network with length: 4 for node AKT1S1_T246 and RELA_S536\n", + "looking for paths in the network with length: 5 for node AKT1S1_T246 and RELA_S536\n", + "looking for paths in the network with length: 6 for node AKT1S1_T246 and RELA_S536\n", + "looking for paths in the network with length: 7 for node AKT1S1_T246 and RELA_S536\n", + "looking for paths in the network with length: 8 for node AKT1S1_T246 and RELA_S536\n", + "looking for paths in the network with length: 9 for node AKT1S1_T246 and RELA_S536\n", + "looking for paths in the network with length: 10 for node AKT1S1_T246 and RELA_S536\n", + "i_search = 4\n", + "Looking for paths with length: 0 for node AKT1S1_T246 and RELA_S536\n", + "i_search = 4\n", + "Looking for paths with length: 1 for node AKT1S1_T246 and RELA_S536\n", + "i_search = 4\n", + "Looking for paths with length: 2 for node AKT1S1_T246 and RELA_S536\n", + "i_search = 4\n", + "Looking for paths with length: 3 for node AKT1S1_T246 and RELA_S536\n", + "i_search = 4\n", + "Looking for paths with length: 4 for node AKT1S1_T246 and RELA_S536\n", + "looking for paths in the network with length: 0 for node AKT1S1_T246 and MARCKS_S170\n", + "looking for paths in the network with length: 1 for node AKT1S1_T246 and MARCKS_S170\n", + "looking for paths in the network with length: 2 for node AKT1S1_T246 and MARCKS_S170\n", + "looking for paths in the network with length: 3 for node AKT1S1_T246 and MARCKS_S170\n", + "looking for paths in the network with length: 4 for node AKT1S1_T246 and MARCKS_S170\n", + "looking for paths in the network with length: 5 for node AKT1S1_T246 and MARCKS_S170\n", + "looking for paths in the network with length: 6 for node AKT1S1_T246 and MARCKS_S170\n", + "looking for paths in the network with length: 7 for node AKT1S1_T246 and MARCKS_S170\n", + "looking for paths in the network with length: 8 for node AKT1S1_T246 and MARCKS_S170\n", + "looking for paths in the network with length: 9 for node AKT1S1_T246 and MARCKS_S170\n", + "looking for paths in the network with length: 10 for node AKT1S1_T246 and MARCKS_S170\n", + "i_search = 4\n", + "Looking for paths with length: 0 for node AKT1S1_T246 and MARCKS_S170\n", + "i_search = 4\n", + "Looking for paths with length: 1 for node AKT1S1_T246 and MARCKS_S170\n", + "i_search = 4\n", + "Looking for paths with length: 2 for node AKT1S1_T246 and MARCKS_S170\n", + "i_search = 4\n", + "Looking for paths with length: 3 for node AKT1S1_T246 and MARCKS_S170\n", + "i_search = 4\n", + "Looking for paths with length: 4 for node AKT1S1_T246 and MARCKS_S170\n", + "looking for paths in the network with length: 0 for node AKT1S1_T246 and SMAD3\n", + "looking for paths in the network with length: 1 for node AKT1S1_T246 and SMAD3\n", + "looking for paths in the network with length: 2 for node AKT1S1_T246 and SMAD3\n", + "looking for paths in the network with length: 3 for node AKT1S1_T246 and SMAD3\n", + "looking for paths in the network with length: 4 for node AKT1S1_T246 and SMAD3\n", + "looking for paths in the network with length: 5 for node AKT1S1_T246 and SMAD3\n", + "looking for paths in the network with length: 6 for node AKT1S1_T246 and SMAD3\n", + "looking for paths in the network with length: 7 for node AKT1S1_T246 and SMAD3\n", + "looking for paths in the network with length: 8 for node AKT1S1_T246 and SMAD3\n", + "looking for paths in the network with length: 9 for node AKT1S1_T246 and SMAD3\n", + "looking for paths in the network with length: 10 for node AKT1S1_T246 and SMAD3\n", + "i_search = 4\n", + "Looking for paths with length: 0 for node AKT1S1_T246 and SMAD3\n", + "i_search = 4\n", + "Looking for paths with length: 1 for node AKT1S1_T246 and SMAD3\n", + "i_search = 4\n", + "Looking for paths with length: 2 for node AKT1S1_T246 and SMAD3\n", + "i_search = 4\n", + "Looking for paths with length: 3 for node AKT1S1_T246 and SMAD3\n", + "i_search = 4\n", + "Looking for paths with length: 4 for node AKT1S1_T246 and SMAD3\n", + "looking for paths in the network with length: 0 for node AKT1S1_T246 and TP53\n", + "looking for paths in the network with length: 1 for node AKT1S1_T246 and TP53\n", + "looking for paths in the network with length: 2 for node AKT1S1_T246 and TP53\n", + "looking for paths in the network with length: 3 for node AKT1S1_T246 and TP53\n", + "looking for paths in the network with length: 4 for node AKT1S1_T246 and TP53\n", + "looking for paths in the network with length: 5 for node AKT1S1_T246 and TP53\n", + "looking for paths in the network with length: 6 for node AKT1S1_T246 and TP53\n", + "looking for paths in the network with length: 7 for node AKT1S1_T246 and TP53\n", + "looking for paths in the network with length: 8 for node AKT1S1_T246 and TP53\n", + "looking for paths in the network with length: 9 for node AKT1S1_T246 and TP53\n", + "looking for paths in the network with length: 10 for node AKT1S1_T246 and TP53\n", + "i_search = 4\n", + "Looking for paths with length: 0 for node AKT1S1_T246 and TP53\n", + "i_search = 4\n", + "Looking for paths with length: 1 for node AKT1S1_T246 and TP53\n", + "i_search = 4\n", + "Looking for paths with length: 2 for node AKT1S1_T246 and TP53\n", + "i_search = 4\n", + "Looking for paths with length: 3 for node AKT1S1_T246 and TP53\n", + "i_search = 4\n", + "Looking for paths with length: 4 for node AKT1S1_T246 and TP53\n", + "looking for paths in the network with length: 0 for node AKT1S1_T246 and AKT1S1\n", + "looking for paths in the network with length: 1 for node AKT1S1_T246 and AKT1S1\n", + "looking for paths in the network with length: 2 for node AKT1S1_T246 and AKT1S1\n", + "looking for paths in the network with length: 3 for node AKT1S1_T246 and AKT1S1\n", + "looking for paths in the network with length: 4 for node AKT1S1_T246 and AKT1S1\n", + "looking for paths in the network with length: 5 for node AKT1S1_T246 and AKT1S1\n", + "looking for paths in the network with length: 6 for node AKT1S1_T246 and AKT1S1\n", + "looking for paths in the network with length: 7 for node AKT1S1_T246 and AKT1S1\n", + "looking for paths in the network with length: 8 for node AKT1S1_T246 and AKT1S1\n", + "looking for paths in the network with length: 9 for node AKT1S1_T246 and AKT1S1\n", + "looking for paths in the network with length: 10 for node AKT1S1_T246 and AKT1S1\n", + "i_search = 4\n", + "Looking for paths with length: 0 for node AKT1S1_T246 and AKT1S1\n", + "i_search = 4\n", + "Looking for paths with length: 1 for node AKT1S1_T246 and AKT1S1\n", + "i_search = 4\n", + "Looking for paths with length: 2 for node AKT1S1_T246 and AKT1S1\n", + "i_search = 4\n", + "Looking for paths with length: 3 for node AKT1S1_T246 and AKT1S1\n", + "i_search = 4\n", + "Looking for paths with length: 4 for node AKT1S1_T246 and AKT1S1\n", + "looking for paths in the network with length: 0 for node AKT1S1_T246 and GSK3B\n", + "looking for paths in the network with length: 1 for node AKT1S1_T246 and GSK3B\n", + "looking for paths in the network with length: 2 for node AKT1S1_T246 and GSK3B\n", + "looking for paths in the network with length: 3 for node AKT1S1_T246 and GSK3B\n", + "looking for paths in the network with length: 4 for node AKT1S1_T246 and GSK3B\n", + "looking for paths in the network with length: 5 for node AKT1S1_T246 and GSK3B\n", + "looking for paths in the network with length: 6 for node AKT1S1_T246 and GSK3B\n", + "looking for paths in the network with length: 7 for node AKT1S1_T246 and GSK3B\n", + "looking for paths in the network with length: 8 for node AKT1S1_T246 and GSK3B\n", + "looking for paths in the network with length: 9 for node AKT1S1_T246 and GSK3B\n", + "looking for paths in the network with length: 10 for node AKT1S1_T246 and GSK3B\n", + "i_search = 4\n", + "Looking for paths with length: 0 for node AKT1S1_T246 and GSK3B\n", + "i_search = 4\n", + "Looking for paths with length: 1 for node AKT1S1_T246 and GSK3B\n", + "i_search = 4\n", + "Looking for paths with length: 2 for node AKT1S1_T246 and GSK3B\n", + "i_search = 4\n", + "Looking for paths with length: 3 for node AKT1S1_T246 and GSK3B\n", + "i_search = 4\n", + "Looking for paths with length: 4 for node AKT1S1_T246 and GSK3B\n", + "looking for paths in the network with length: 0 for node AKT1S1_T246 and AKT1\n", + "looking for paths in the network with length: 1 for node AKT1S1_T246 and AKT1\n", + "looking for paths in the network with length: 2 for node AKT1S1_T246 and AKT1\n", + "looking for paths in the network with length: 3 for node AKT1S1_T246 and AKT1\n", + "looking for paths in the network with length: 4 for node AKT1S1_T246 and AKT1\n", + "looking for paths in the network with length: 5 for node AKT1S1_T246 and AKT1\n", + "looking for paths in the network with length: 6 for node AKT1S1_T246 and AKT1\n", + "looking for paths in the network with length: 7 for node AKT1S1_T246 and AKT1\n", + "looking for paths in the network with length: 8 for node AKT1S1_T246 and AKT1\n", + "looking for paths in the network with length: 9 for node AKT1S1_T246 and AKT1\n", + "looking for paths in the network with length: 10 for node AKT1S1_T246 and AKT1\n", + "i_search = 4\n", + "Looking for paths with length: 0 for node AKT1S1_T246 and AKT1\n", + "i_search = 4\n", + "Looking for paths with length: 1 for node AKT1S1_T246 and AKT1\n", + "i_search = 4\n", + "Looking for paths with length: 2 for node AKT1S1_T246 and AKT1\n", + "i_search = 4\n", + "Looking for paths with length: 3 for node AKT1S1_T246 and AKT1\n", + "i_search = 4\n", + "Looking for paths with length: 4 for node AKT1S1_T246 and AKT1\n", + "looking for paths in the network with length: 0 for node AKT1S1_T246 and HSPB1\n", + "looking for paths in the network with length: 1 for node AKT1S1_T246 and HSPB1\n", + "looking for paths in the network with length: 2 for node AKT1S1_T246 and HSPB1\n", + "looking for paths in the network with length: 3 for node AKT1S1_T246 and HSPB1\n", + "looking for paths in the network with length: 4 for node AKT1S1_T246 and HSPB1\n", + "looking for paths in the network with length: 5 for node AKT1S1_T246 and HSPB1\n", + "looking for paths in the network with length: 6 for node AKT1S1_T246 and HSPB1\n", + "looking for paths in the network with length: 7 for node AKT1S1_T246 and HSPB1\n", + "looking for paths in the network with length: 8 for node AKT1S1_T246 and HSPB1\n", + "looking for paths in the network with length: 9 for node AKT1S1_T246 and HSPB1\n", + "looking for paths in the network with length: 10 for node AKT1S1_T246 and HSPB1\n", + "i_search = 4\n", + "Looking for paths with length: 0 for node AKT1S1_T246 and HSPB1\n", + "i_search = 4\n", + "Looking for paths with length: 1 for node AKT1S1_T246 and HSPB1\n", + "i_search = 4\n", + "Looking for paths with length: 2 for node AKT1S1_T246 and HSPB1\n", + "i_search = 4\n", + "Looking for paths with length: 3 for node AKT1S1_T246 and HSPB1\n", + "i_search = 4\n", + "Looking for paths with length: 4 for node AKT1S1_T246 and HSPB1\n", + "looking for paths in the network with length: 0 for node AKT1S1_T246 and MAPK14\n", + "looking for paths in the network with length: 1 for node AKT1S1_T246 and MAPK14\n", + "looking for paths in the network with length: 2 for node AKT1S1_T246 and MAPK14\n", + "looking for paths in the network with length: 3 for node AKT1S1_T246 and MAPK14\n", + "looking for paths in the network with length: 4 for node AKT1S1_T246 and MAPK14\n", + "looking for paths in the network with length: 5 for node AKT1S1_T246 and MAPK14\n", + "looking for paths in the network with length: 6 for node AKT1S1_T246 and MAPK14\n", + "looking for paths in the network with length: 7 for node AKT1S1_T246 and MAPK14\n", + "looking for paths in the network with length: 8 for node AKT1S1_T246 and MAPK14\n", + "looking for paths in the network with length: 9 for node AKT1S1_T246 and MAPK14\n", + "looking for paths in the network with length: 10 for node AKT1S1_T246 and MAPK14\n", + "i_search = 4\n", + "Looking for paths with length: 0 for node AKT1S1_T246 and MAPK14\n", + "i_search = 4\n", + "Looking for paths with length: 1 for node AKT1S1_T246 and MAPK14\n", + "i_search = 4\n", + "Looking for paths with length: 2 for node AKT1S1_T246 and MAPK14\n", + "i_search = 4\n", + "Looking for paths with length: 3 for node AKT1S1_T246 and MAPK14\n", + "i_search = 4\n", + "Looking for paths with length: 4 for node AKT1S1_T246 and MAPK14\n", + "looking for paths in the network with length: 0 for node AKT1S1_T246 and MAP2K1\n", + "looking for paths in the network with length: 1 for node AKT1S1_T246 and MAP2K1\n", + "looking for paths in the network with length: 2 for node AKT1S1_T246 and MAP2K1\n", + "looking for paths in the network with length: 3 for node AKT1S1_T246 and MAP2K1\n", + "looking for paths in the network with length: 4 for node AKT1S1_T246 and MAP2K1\n", + "looking for paths in the network with length: 5 for node AKT1S1_T246 and MAP2K1\n", + "looking for paths in the network with length: 6 for node AKT1S1_T246 and MAP2K1\n", + "looking for paths in the network with length: 7 for node AKT1S1_T246 and MAP2K1\n", + "looking for paths in the network with length: 8 for node AKT1S1_T246 and MAP2K1\n", + "looking for paths in the network with length: 9 for node AKT1S1_T246 and MAP2K1\n", + "looking for paths in the network with length: 10 for node AKT1S1_T246 and MAP2K1\n", + "i_search = 4\n", + "Looking for paths with length: 0 for node AKT1S1_T246 and MAP2K1\n", + "i_search = 4\n", + "Looking for paths with length: 1 for node AKT1S1_T246 and MAP2K1\n", + "i_search = 4\n", + "Looking for paths with length: 2 for node AKT1S1_T246 and MAP2K1\n", + "i_search = 4\n", + "Looking for paths with length: 3 for node AKT1S1_T246 and MAP2K1\n", + "i_search = 4\n", + "Looking for paths with length: 4 for node AKT1S1_T246 and MAP2K1\n", + "looking for paths in the network with length: 0 for node AKT1S1_T246 and RPS6KA1\n", + "looking for paths in the network with length: 1 for node AKT1S1_T246 and RPS6KA1\n", + "looking for paths in the network with length: 2 for node AKT1S1_T246 and RPS6KA1\n", + "looking for paths in the network with length: 3 for node AKT1S1_T246 and RPS6KA1\n", + "looking for paths in the network with length: 4 for node AKT1S1_T246 and RPS6KA1\n", + "looking for paths in the network with length: 5 for node AKT1S1_T246 and RPS6KA1\n", + "looking for paths in the network with length: 6 for node AKT1S1_T246 and RPS6KA1\n", + "looking for paths in the network with length: 7 for node AKT1S1_T246 and RPS6KA1\n", + "looking for paths in the network with length: 8 for node AKT1S1_T246 and RPS6KA1\n", + "looking for paths in the network with length: 9 for node AKT1S1_T246 and RPS6KA1\n", + "looking for paths in the network with length: 10 for node AKT1S1_T246 and RPS6KA1\n", + "i_search = 4\n", + "Looking for paths with length: 0 for node AKT1S1_T246 and RPS6KA1\n", + "i_search = 4\n", + "Looking for paths with length: 1 for node AKT1S1_T246 and RPS6KA1\n", + "i_search = 4\n", + "Looking for paths with length: 2 for node AKT1S1_T246 and RPS6KA1\n", + "i_search = 4\n", + "Looking for paths with length: 3 for node AKT1S1_T246 and RPS6KA1\n", + "i_search = 4\n", + "Looking for paths with length: 4 for node AKT1S1_T246 and RPS6KA1\n", + "looking for paths in the network with length: 0 for node AKT1S1_T246 and CREB1\n", + "looking for paths in the network with length: 1 for node AKT1S1_T246 and CREB1\n", + "looking for paths in the network with length: 2 for node AKT1S1_T246 and CREB1\n", + "looking for paths in the network with length: 3 for node AKT1S1_T246 and CREB1\n", + "looking for paths in the network with length: 4 for node AKT1S1_T246 and CREB1\n", + "looking for paths in the network with length: 5 for node AKT1S1_T246 and CREB1\n", + "looking for paths in the network with length: 6 for node AKT1S1_T246 and CREB1\n", + "looking for paths in the network with length: 7 for node AKT1S1_T246 and CREB1\n", + "looking for paths in the network with length: 8 for node AKT1S1_T246 and CREB1\n", + "looking for paths in the network with length: 9 for node AKT1S1_T246 and CREB1\n", + "looking for paths in the network with length: 10 for node AKT1S1_T246 and CREB1\n", + "i_search = 4\n", + "Looking for paths with length: 0 for node AKT1S1_T246 and CREB1\n", + "i_search = 4\n", + "Looking for paths with length: 1 for node AKT1S1_T246 and CREB1\n", + "i_search = 4\n", + "Looking for paths with length: 2 for node AKT1S1_T246 and CREB1\n", + "i_search = 4\n", + "Looking for paths with length: 3 for node AKT1S1_T246 and CREB1\n", + "i_search = 4\n", + "Looking for paths with length: 4 for node AKT1S1_T246 and CREB1\n", + "looking for paths in the network with length: 0 for node AKT1S1_T246 and NFKBIA\n", + "looking for paths in the network with length: 1 for node AKT1S1_T246 and NFKBIA\n", + "looking for paths in the network with length: 2 for node AKT1S1_T246 and NFKBIA\n", + "looking for paths in the network with length: 3 for node AKT1S1_T246 and NFKBIA\n", + "looking for paths in the network with length: 4 for node AKT1S1_T246 and NFKBIA\n", + "looking for paths in the network with length: 5 for node AKT1S1_T246 and NFKBIA\n", + "looking for paths in the network with length: 6 for node AKT1S1_T246 and NFKBIA\n", + "looking for paths in the network with length: 7 for node AKT1S1_T246 and NFKBIA\n", + "looking for paths in the network with length: 8 for node AKT1S1_T246 and NFKBIA\n", + "looking for paths in the network with length: 9 for node AKT1S1_T246 and NFKBIA\n", + "looking for paths in the network with length: 10 for node AKT1S1_T246 and NFKBIA\n", + "i_search = 4\n", + "Looking for paths with length: 0 for node AKT1S1_T246 and NFKBIA\n", + "i_search = 4\n", + "Looking for paths with length: 1 for node AKT1S1_T246 and NFKBIA\n", + "i_search = 4\n", + "Looking for paths with length: 2 for node AKT1S1_T246 and NFKBIA\n", + "i_search = 4\n", + "Looking for paths with length: 3 for node AKT1S1_T246 and NFKBIA\n", + "i_search = 4\n", + "Looking for paths with length: 4 for node AKT1S1_T246 and NFKBIA\n", + "looking for paths in the network with length: 0 for node AKT1S1_T246 and MTOR\n", + "looking for paths in the network with length: 1 for node AKT1S1_T246 and MTOR\n", + "looking for paths in the network with length: 2 for node AKT1S1_T246 and MTOR\n", + "looking for paths in the network with length: 3 for node AKT1S1_T246 and MTOR\n", + "looking for paths in the network with length: 4 for node AKT1S1_T246 and MTOR\n", + "looking for paths in the network with length: 5 for node AKT1S1_T246 and MTOR\n", + "looking for paths in the network with length: 6 for node AKT1S1_T246 and MTOR\n", + "looking for paths in the network with length: 7 for node AKT1S1_T246 and MTOR\n", + "looking for paths in the network with length: 8 for node AKT1S1_T246 and MTOR\n", + "looking for paths in the network with length: 9 for node AKT1S1_T246 and MTOR\n", + "looking for paths in the network with length: 10 for node AKT1S1_T246 and MTOR\n", + "i_search = 4\n", + "Looking for paths with length: 0 for node AKT1S1_T246 and MTOR\n", + "i_search = 4\n", + "Looking for paths with length: 1 for node AKT1S1_T246 and MTOR\n", + "i_search = 4\n", + "Looking for paths with length: 2 for node AKT1S1_T246 and MTOR\n", + "i_search = 4\n", + "Looking for paths with length: 3 for node AKT1S1_T246 and MTOR\n", + "i_search = 4\n", + "Looking for paths with length: 4 for node AKT1S1_T246 and MTOR\n", + "looking for paths in the network with length: 0 for node AKT1S1_T246 and JUN\n", + "looking for paths in the network with length: 1 for node AKT1S1_T246 and JUN\n", + "looking for paths in the network with length: 2 for node AKT1S1_T246 and JUN\n", + "looking for paths in the network with length: 3 for node AKT1S1_T246 and JUN\n", + "looking for paths in the network with length: 4 for node AKT1S1_T246 and JUN\n", + "looking for paths in the network with length: 5 for node AKT1S1_T246 and JUN\n", + "looking for paths in the network with length: 6 for node AKT1S1_T246 and JUN\n", + "looking for paths in the network with length: 7 for node AKT1S1_T246 and JUN\n", + "looking for paths in the network with length: 8 for node AKT1S1_T246 and JUN\n", + "looking for paths in the network with length: 9 for node AKT1S1_T246 and JUN\n", + "looking for paths in the network with length: 10 for node AKT1S1_T246 and JUN\n", + "i_search = 4\n", + "Looking for paths with length: 0 for node AKT1S1_T246 and JUN\n", + "i_search = 4\n", + "Looking for paths with length: 1 for node AKT1S1_T246 and JUN\n", + "i_search = 4\n", + "Looking for paths with length: 2 for node AKT1S1_T246 and JUN\n", + "i_search = 4\n", + "Looking for paths with length: 3 for node AKT1S1_T246 and JUN\n", + "i_search = 4\n", + "Looking for paths with length: 4 for node AKT1S1_T246 and JUN\n", + "looking for paths in the network with length: 0 for node AKT1S1_T246 and EGFR\n", + "looking for paths in the network with length: 1 for node AKT1S1_T246 and EGFR\n", + "looking for paths in the network with length: 2 for node AKT1S1_T246 and EGFR\n", + "looking for paths in the network with length: 3 for node AKT1S1_T246 and EGFR\n", + "looking for paths in the network with length: 4 for node AKT1S1_T246 and EGFR\n", + "looking for paths in the network with length: 5 for node AKT1S1_T246 and EGFR\n", + "looking for paths in the network with length: 6 for node AKT1S1_T246 and EGFR\n", + "looking for paths in the network with length: 7 for node AKT1S1_T246 and EGFR\n", + "looking for paths in the network with length: 8 for node AKT1S1_T246 and EGFR\n", + "looking for paths in the network with length: 9 for node AKT1S1_T246 and EGFR\n", + "looking for paths in the network with length: 10 for node AKT1S1_T246 and EGFR\n", + "i_search = 4\n", + "Looking for paths with length: 0 for node AKT1S1_T246 and EGFR\n", + "i_search = 4\n", + "Looking for paths with length: 1 for node AKT1S1_T246 and EGFR\n", + "i_search = 4\n", + "Looking for paths with length: 2 for node AKT1S1_T246 and EGFR\n", + "i_search = 4\n", + "Looking for paths with length: 3 for node AKT1S1_T246 and EGFR\n", + "i_search = 4\n", + "Looking for paths with length: 4 for node AKT1S1_T246 and EGFR\n", + "looking for paths in the network with length: 0 for node AKT1S1_T246 and MAPK3\n", + "looking for paths in the network with length: 1 for node AKT1S1_T246 and MAPK3\n", + "looking for paths in the network with length: 2 for node AKT1S1_T246 and MAPK3\n", + "looking for paths in the network with length: 3 for node AKT1S1_T246 and MAPK3\n", + "looking for paths in the network with length: 4 for node AKT1S1_T246 and MAPK3\n", + "looking for paths in the network with length: 5 for node AKT1S1_T246 and MAPK3\n", + "looking for paths in the network with length: 6 for node AKT1S1_T246 and MAPK3\n", + "looking for paths in the network with length: 7 for node AKT1S1_T246 and MAPK3\n", + "looking for paths in the network with length: 8 for node AKT1S1_T246 and MAPK3\n", + "looking for paths in the network with length: 9 for node AKT1S1_T246 and MAPK3\n", + "looking for paths in the network with length: 10 for node AKT1S1_T246 and MAPK3\n", + "i_search = 4\n", + "Looking for paths with length: 0 for node AKT1S1_T246 and MAPK3\n", + "i_search = 4\n", + "Looking for paths with length: 1 for node AKT1S1_T246 and MAPK3\n", + "i_search = 4\n", + "Looking for paths with length: 2 for node AKT1S1_T246 and MAPK3\n", + "i_search = 4\n", + "Looking for paths with length: 3 for node AKT1S1_T246 and MAPK3\n", + "i_search = 4\n", + "Looking for paths with length: 4 for node AKT1S1_T246 and MAPK3\n", + "looking for paths in the network with length: 0 for node AKT1S1_T246 and PTPN11\n", + "looking for paths in the network with length: 1 for node AKT1S1_T246 and PTPN11\n", + "looking for paths in the network with length: 2 for node AKT1S1_T246 and PTPN11\n", + "looking for paths in the network with length: 3 for node AKT1S1_T246 and PTPN11\n", + "looking for paths in the network with length: 4 for node AKT1S1_T246 and PTPN11\n", + "looking for paths in the network with length: 5 for node AKT1S1_T246 and PTPN11\n", + "looking for paths in the network with length: 6 for node AKT1S1_T246 and PTPN11\n", + "looking for paths in the network with length: 7 for node AKT1S1_T246 and PTPN11\n", + "looking for paths in the network with length: 8 for node AKT1S1_T246 and PTPN11\n", + "looking for paths in the network with length: 9 for node AKT1S1_T246 and PTPN11\n", + "looking for paths in the network with length: 10 for node AKT1S1_T246 and PTPN11\n", + "i_search = 4\n", + "Looking for paths with length: 0 for node AKT1S1_T246 and PTPN11\n", + "i_search = 4\n", + "Looking for paths with length: 1 for node AKT1S1_T246 and PTPN11\n", + "i_search = 4\n", + "Looking for paths with length: 2 for node AKT1S1_T246 and PTPN11\n", + "i_search = 4\n", + "Looking for paths with length: 3 for node AKT1S1_T246 and PTPN11\n", + "i_search = 4\n", + "Looking for paths with length: 4 for node AKT1S1_T246 and PTPN11\n", + "looking for paths in the network with length: 0 for node AKT1S1_T246 and STAT3\n", + "looking for paths in the network with length: 1 for node AKT1S1_T246 and STAT3\n", + "looking for paths in the network with length: 2 for node AKT1S1_T246 and STAT3\n", + "looking for paths in the network with length: 3 for node AKT1S1_T246 and STAT3\n", + "looking for paths in the network with length: 4 for node AKT1S1_T246 and STAT3\n", + "looking for paths in the network with length: 5 for node AKT1S1_T246 and STAT3\n", + "looking for paths in the network with length: 6 for node AKT1S1_T246 and STAT3\n", + "looking for paths in the network with length: 7 for node AKT1S1_T246 and STAT3\n", + "looking for paths in the network with length: 8 for node AKT1S1_T246 and STAT3\n", + "looking for paths in the network with length: 9 for node AKT1S1_T246 and STAT3\n", + "looking for paths in the network with length: 10 for node AKT1S1_T246 and STAT3\n", + "i_search = 4\n", + "Looking for paths with length: 0 for node AKT1S1_T246 and STAT3\n", + "i_search = 4\n", + "Looking for paths with length: 1 for node AKT1S1_T246 and STAT3\n", + "i_search = 4\n", + "Looking for paths with length: 2 for node AKT1S1_T246 and STAT3\n", + "i_search = 4\n", + "Looking for paths with length: 3 for node AKT1S1_T246 and STAT3\n", + "i_search = 4\n", + "Looking for paths with length: 4 for node AKT1S1_T246 and STAT3\n", + "looking for paths in the network with length: 0 for node AKT1S1_T246 and CHEK2\n", + "looking for paths in the network with length: 1 for node AKT1S1_T246 and CHEK2\n", + "looking for paths in the network with length: 2 for node AKT1S1_T246 and CHEK2\n", + "looking for paths in the network with length: 3 for node AKT1S1_T246 and CHEK2\n", + "looking for paths in the network with length: 4 for node AKT1S1_T246 and CHEK2\n", + "looking for paths in the network with length: 5 for node AKT1S1_T246 and CHEK2\n", + "looking for paths in the network with length: 6 for node AKT1S1_T246 and CHEK2\n", + "looking for paths in the network with length: 7 for node AKT1S1_T246 and CHEK2\n", + "looking for paths in the network with length: 8 for node AKT1S1_T246 and CHEK2\n", + "looking for paths in the network with length: 9 for node AKT1S1_T246 and CHEK2\n", + "looking for paths in the network with length: 10 for node AKT1S1_T246 and CHEK2\n", + "i_search = 4\n", + "Looking for paths with length: 0 for node AKT1S1_T246 and CHEK2\n", + "i_search = 4\n", + "Looking for paths with length: 1 for node AKT1S1_T246 and CHEK2\n", + "i_search = 4\n", + "Looking for paths with length: 2 for node AKT1S1_T246 and CHEK2\n", + "i_search = 4\n", + "Looking for paths with length: 3 for node AKT1S1_T246 and CHEK2\n", + "i_search = 4\n", + "Looking for paths with length: 4 for node AKT1S1_T246 and CHEK2\n", + "looking for paths in the network with length: 0 for node AKT1S1_T246 and RELA\n", + "looking for paths in the network with length: 1 for node AKT1S1_T246 and RELA\n", + "looking for paths in the network with length: 2 for node AKT1S1_T246 and RELA\n", + "looking for paths in the network with length: 3 for node AKT1S1_T246 and RELA\n", + "looking for paths in the network with length: 4 for node AKT1S1_T246 and RELA\n", + "looking for paths in the network with length: 5 for node AKT1S1_T246 and RELA\n", + "looking for paths in the network with length: 6 for node AKT1S1_T246 and RELA\n", + "looking for paths in the network with length: 7 for node AKT1S1_T246 and RELA\n", + "looking for paths in the network with length: 8 for node AKT1S1_T246 and RELA\n", + "looking for paths in the network with length: 9 for node AKT1S1_T246 and RELA\n", + "looking for paths in the network with length: 10 for node AKT1S1_T246 and RELA\n", + "i_search = 4\n", + "Looking for paths with length: 0 for node AKT1S1_T246 and RELA\n", + "i_search = 4\n", + "Looking for paths with length: 1 for node AKT1S1_T246 and RELA\n", + "i_search = 4\n", + "Looking for paths with length: 2 for node AKT1S1_T246 and RELA\n", + "i_search = 4\n", + "Looking for paths with length: 3 for node AKT1S1_T246 and RELA\n", + "i_search = 4\n", + "Looking for paths with length: 4 for node AKT1S1_T246 and RELA\n", + "looking for paths in the network with length: 0 for node AKT1S1_T246 and MARCKS\n", + "looking for paths in the network with length: 1 for node AKT1S1_T246 and MARCKS\n", + "looking for paths in the network with length: 2 for node AKT1S1_T246 and MARCKS\n", + "looking for paths in the network with length: 3 for node AKT1S1_T246 and MARCKS\n", + "looking for paths in the network with length: 4 for node AKT1S1_T246 and MARCKS\n", + "looking for paths in the network with length: 5 for node AKT1S1_T246 and MARCKS\n", + "looking for paths in the network with length: 6 for node AKT1S1_T246 and MARCKS\n", + "looking for paths in the network with length: 7 for node AKT1S1_T246 and MARCKS\n", + "looking for paths in the network with length: 8 for node AKT1S1_T246 and MARCKS\n", + "looking for paths in the network with length: 9 for node AKT1S1_T246 and MARCKS\n", + "looking for paths in the network with length: 10 for node AKT1S1_T246 and MARCKS\n", + "i_search = 4\n", + "Looking for paths with length: 0 for node AKT1S1_T246 and MARCKS\n", + "i_search = 4\n", + "Looking for paths with length: 1 for node AKT1S1_T246 and MARCKS\n", + "i_search = 4\n", + "Looking for paths with length: 2 for node AKT1S1_T246 and MARCKS\n", + "i_search = 4\n", + "Looking for paths with length: 3 for node AKT1S1_T246 and MARCKS\n", + "i_search = 4\n", + "Looking for paths with length: 4 for node AKT1S1_T246 and MARCKS\n", + "looking for paths in the network with length: 0 for node GSK3B_S9 and GSK3B_S21\n", + "looking for paths in the network with length: 1 for node GSK3B_S9 and GSK3B_S21\n", + "looking for paths in the network with length: 2 for node GSK3B_S9 and GSK3B_S21\n", + "looking for paths in the network with length: 3 for node GSK3B_S9 and GSK3B_S21\n", + "looking for paths in the network with length: 4 for node GSK3B_S9 and GSK3B_S21\n", + "looking for paths in the network with length: 5 for node GSK3B_S9 and GSK3B_S21\n", + "looking for paths in the network with length: 6 for node GSK3B_S9 and GSK3B_S21\n", + "looking for paths in the network with length: 7 for node GSK3B_S9 and GSK3B_S21\n", + "looking for paths in the network with length: 8 for node GSK3B_S9 and GSK3B_S21\n", + "looking for paths in the network with length: 9 for node GSK3B_S9 and GSK3B_S21\n", + "looking for paths in the network with length: 10 for node GSK3B_S9 and GSK3B_S21\n", + "i_search = 4\n", + "Looking for paths with length: 0 for node GSK3B_S9 and GSK3B_S21\n", + "i_search = 4\n", + "Looking for paths with length: 1 for node GSK3B_S9 and GSK3B_S21\n", + "i_search = 4\n", + "Looking for paths with length: 2 for node GSK3B_S9 and GSK3B_S21\n", + "i_search = 4\n", + "Looking for paths with length: 3 for node GSK3B_S9 and GSK3B_S21\n", + "i_search = 4\n", + "Looking for paths with length: 4 for node GSK3B_S9 and GSK3B_S21\n", + "looking for paths in the network with length: 0 for node GSK3B_S9 and AKT1_S473\n", + "looking for paths in the network with length: 1 for node GSK3B_S9 and AKT1_S473\n", + "looking for paths in the network with length: 2 for node GSK3B_S9 and AKT1_S473\n", + "looking for paths in the network with length: 3 for node GSK3B_S9 and AKT1_S473\n", + "looking for paths in the network with length: 4 for node GSK3B_S9 and AKT1_S473\n", + "looking for paths in the network with length: 5 for node GSK3B_S9 and AKT1_S473\n", + "looking for paths in the network with length: 6 for node GSK3B_S9 and AKT1_S473\n", + "looking for paths in the network with length: 7 for node GSK3B_S9 and AKT1_S473\n", + "looking for paths in the network with length: 8 for node GSK3B_S9 and AKT1_S473\n", + "looking for paths in the network with length: 9 for node GSK3B_S9 and AKT1_S473\n", + "looking for paths in the network with length: 10 for node GSK3B_S9 and AKT1_S473\n", + "i_search = 4\n", + "Looking for paths with length: 0 for node GSK3B_S9 and AKT1_S473\n", + "i_search = 4\n", + "Looking for paths with length: 1 for node GSK3B_S9 and AKT1_S473\n", + "i_search = 4\n", + "Looking for paths with length: 2 for node GSK3B_S9 and AKT1_S473\n", + "[['GSK3B_S9', 'AKT1', 'AKT1_S473']]\n", + "AKT1 GSK3B_S9\n", + "AKT1_S473 AKT1\n", + "looking for paths in the network with length: 0 for node GSK3B_S9 and HSPB1_S78\n", + "looking for paths in the network with length: 1 for node GSK3B_S9 and HSPB1_S78\n", + "looking for paths in the network with length: 2 for node GSK3B_S9 and HSPB1_S78\n", + "looking for paths in the network with length: 3 for node GSK3B_S9 and HSPB1_S78\n", + "looking for paths in the network with length: 4 for node GSK3B_S9 and HSPB1_S78\n", + "looking for paths in the network with length: 5 for node GSK3B_S9 and HSPB1_S78\n", + "looking for paths in the network with length: 6 for node GSK3B_S9 and HSPB1_S78\n", + "looking for paths in the network with length: 7 for node GSK3B_S9 and HSPB1_S78\n", + "looking for paths in the network with length: 8 for node GSK3B_S9 and HSPB1_S78\n", + "looking for paths in the network with length: 9 for node GSK3B_S9 and HSPB1_S78\n", + "looking for paths in the network with length: 10 for node GSK3B_S9 and HSPB1_S78\n", + "i_search = 4\n", + "Looking for paths with length: 0 for node GSK3B_S9 and HSPB1_S78\n", + "i_search = 4\n", + "Looking for paths with length: 1 for node GSK3B_S9 and HSPB1_S78\n", + "i_search = 4\n", + "Looking for paths with length: 2 for node GSK3B_S9 and HSPB1_S78\n", + "i_search = 4\n", + "Looking for paths with length: 3 for node GSK3B_S9 and HSPB1_S78\n", + "i_search = 4\n", + "Looking for paths with length: 4 for node GSK3B_S9 and HSPB1_S78\n", + "looking for paths in the network with length: 0 for node GSK3B_S9 and HSPB1_S82\n", + "looking for paths in the network with length: 1 for node GSK3B_S9 and HSPB1_S82\n", + "looking for paths in the network with length: 2 for node GSK3B_S9 and HSPB1_S82\n", + "looking for paths in the network with length: 3 for node GSK3B_S9 and HSPB1_S82\n", + "looking for paths in the network with length: 4 for node GSK3B_S9 and HSPB1_S82\n", + "looking for paths in the network with length: 5 for node GSK3B_S9 and HSPB1_S82\n", + "looking for paths in the network with length: 6 for node GSK3B_S9 and HSPB1_S82\n", + "looking for paths in the network with length: 7 for node GSK3B_S9 and HSPB1_S82\n", + "looking for paths in the network with length: 8 for node GSK3B_S9 and HSPB1_S82\n", + "looking for paths in the network with length: 9 for node GSK3B_S9 and HSPB1_S82\n", + "looking for paths in the network with length: 10 for node GSK3B_S9 and HSPB1_S82\n", + "i_search = 4\n", + "Looking for paths with length: 0 for node GSK3B_S9 and HSPB1_S82\n", + "i_search = 4\n", + "Looking for paths with length: 1 for node GSK3B_S9 and HSPB1_S82\n", + "i_search = 4\n", + "Looking for paths with length: 2 for node GSK3B_S9 and HSPB1_S82\n", + "i_search = 4\n", + "Looking for paths with length: 3 for node GSK3B_S9 and HSPB1_S82\n", + "i_search = 4\n", + "Looking for paths with length: 4 for node GSK3B_S9 and HSPB1_S82\n", + "looking for paths in the network with length: 0 for node GSK3B_S9 and MAPK14_T180\n", + "looking for paths in the network with length: 1 for node GSK3B_S9 and MAPK14_T180\n", + "looking for paths in the network with length: 2 for node GSK3B_S9 and MAPK14_T180\n", + "looking for paths in the network with length: 3 for node GSK3B_S9 and MAPK14_T180\n", + "looking for paths in the network with length: 4 for node GSK3B_S9 and MAPK14_T180\n", + "looking for paths in the network with length: 5 for node GSK3B_S9 and MAPK14_T180\n", + "looking for paths in the network with length: 6 for node GSK3B_S9 and MAPK14_T180\n", + "looking for paths in the network with length: 7 for node GSK3B_S9 and MAPK14_T180\n", + "looking for paths in the network with length: 8 for node GSK3B_S9 and MAPK14_T180\n", + "looking for paths in the network with length: 9 for node GSK3B_S9 and MAPK14_T180\n", + "looking for paths in the network with length: 10 for node GSK3B_S9 and MAPK14_T180\n", + "i_search = 4\n", + "Looking for paths with length: 0 for node GSK3B_S9 and MAPK14_T180\n", + "i_search = 4\n", + "Looking for paths with length: 1 for node GSK3B_S9 and MAPK14_T180\n", + "i_search = 4\n", + "Looking for paths with length: 2 for node GSK3B_S9 and MAPK14_T180\n", + "i_search = 4\n", + "Looking for paths with length: 3 for node GSK3B_S9 and MAPK14_T180\n", + "i_search = 4\n", + "Looking for paths with length: 4 for node GSK3B_S9 and MAPK14_T180\n", + "[['GSK3B_S9', 'GSK3B', 'GSK3B_T390', 'MAPK14', 'MAPK14_T180'], ['GSK3B_S9', 'GSK3B', 'GSK3B_T43', 'MAPK14', 'MAPK14_T180']]\n", + "GSK3B_S9 GSK3B\n", + "GSK3B_T390 GSK3B\n", + "MAPK14 GSK3B_T390\n", + "MAPK14_T180 MAPK14\n", + "GSK3B_S9 GSK3B\n", + "GSK3B_T43 GSK3B\n", + "MAPK14 GSK3B_T43\n", + "MAPK14_T180 MAPK14\n", + "looking for paths in the network with length: 0 for node GSK3B_S9 and MAPK14_Y182\n", + "looking for paths in the network with length: 1 for node GSK3B_S9 and MAPK14_Y182\n", + "looking for paths in the network with length: 2 for node GSK3B_S9 and MAPK14_Y182\n", + "looking for paths in the network with length: 3 for node GSK3B_S9 and MAPK14_Y182\n", + "looking for paths in the network with length: 4 for node GSK3B_S9 and MAPK14_Y182\n", + "looking for paths in the network with length: 5 for node GSK3B_S9 and MAPK14_Y182\n", + "looking for paths in the network with length: 6 for node GSK3B_S9 and MAPK14_Y182\n", + "looking for paths in the network with length: 7 for node GSK3B_S9 and MAPK14_Y182\n", + "looking for paths in the network with length: 8 for node GSK3B_S9 and MAPK14_Y182\n", + "looking for paths in the network with length: 9 for node GSK3B_S9 and MAPK14_Y182\n", + "looking for paths in the network with length: 10 for node GSK3B_S9 and MAPK14_Y182\n", + "i_search = 4\n", + "Looking for paths with length: 0 for node GSK3B_S9 and MAPK14_Y182\n", + "i_search = 4\n", + "Looking for paths with length: 1 for node GSK3B_S9 and MAPK14_Y182\n", + "i_search = 4\n", + "Looking for paths with length: 2 for node GSK3B_S9 and MAPK14_Y182\n", + "i_search = 4\n", + "Looking for paths with length: 3 for node GSK3B_S9 and MAPK14_Y182\n", + "i_search = 4\n", + "Looking for paths with length: 4 for node GSK3B_S9 and MAPK14_Y182\n", + "[['GSK3B_S9', 'GSK3B', 'GSK3B_T390', 'MAPK14', 'MAPK14_Y182'], ['GSK3B_S9', 'GSK3B', 'GSK3B_T43', 'MAPK14', 'MAPK14_Y182']]\n", + "GSK3B_S9 GSK3B\n", + "GSK3B_T390 GSK3B\n", + "MAPK14 GSK3B_T390\n", + "MAPK14_Y182 MAPK14\n", + "GSK3B_S9 GSK3B\n", + "GSK3B_T43 GSK3B\n", + "MAPK14 GSK3B_T43\n", + "MAPK14_Y182 MAPK14\n", + "looking for paths in the network with length: 0 for node GSK3B_S9 and MAP2K1_S218\n", + "looking for paths in the network with length: 1 for node GSK3B_S9 and MAP2K1_S218\n", + "looking for paths in the network with length: 2 for node GSK3B_S9 and MAP2K1_S218\n", + "looking for paths in the network with length: 3 for node GSK3B_S9 and MAP2K1_S218\n", + "looking for paths in the network with length: 4 for node GSK3B_S9 and MAP2K1_S218\n", + "looking for paths in the network with length: 5 for node GSK3B_S9 and MAP2K1_S218\n", + "looking for paths in the network with length: 6 for node GSK3B_S9 and MAP2K1_S218\n", + "looking for paths in the network with length: 7 for node GSK3B_S9 and MAP2K1_S218\n", + "looking for paths in the network with length: 8 for node GSK3B_S9 and MAP2K1_S218\n", + "looking for paths in the network with length: 9 for node GSK3B_S9 and MAP2K1_S218\n", + "looking for paths in the network with length: 10 for node GSK3B_S9 and MAP2K1_S218\n", + "i_search = 4\n", + "Looking for paths with length: 0 for node GSK3B_S9 and MAP2K1_S218\n", + "i_search = 4\n", + "Looking for paths with length: 1 for node GSK3B_S9 and MAP2K1_S218\n", + "i_search = 4\n", + "Looking for paths with length: 2 for node GSK3B_S9 and MAP2K1_S218\n", + "i_search = 4\n", + "Looking for paths with length: 3 for node GSK3B_S9 and MAP2K1_S218\n", + "i_search = 4\n", + "Looking for paths with length: 4 for node GSK3B_S9 and MAP2K1_S218\n", + "[['GSK3B_S9', 'GSK3B', 'GSK3B_Y216', 'MAP2K1', 'MAP2K1_S218']]\n", + "GSK3B_S9 GSK3B\n", + "GSK3B GSK3B_Y216\n", + "MAP2K1 GSK3B_Y216\n", + "MAP2K1_S218 MAP2K1\n", + "looking for paths in the network with length: 0 for node GSK3B_S9 and MAP2K1_S222\n", + "looking for paths in the network with length: 1 for node GSK3B_S9 and MAP2K1_S222\n", + "looking for paths in the network with length: 2 for node GSK3B_S9 and MAP2K1_S222\n", + "looking for paths in the network with length: 3 for node GSK3B_S9 and MAP2K1_S222\n", + "looking for paths in the network with length: 4 for node GSK3B_S9 and MAP2K1_S222\n", + "looking for paths in the network with length: 5 for node GSK3B_S9 and MAP2K1_S222\n", + "looking for paths in the network with length: 6 for node GSK3B_S9 and MAP2K1_S222\n", + "looking for paths in the network with length: 7 for node GSK3B_S9 and MAP2K1_S222\n", + "looking for paths in the network with length: 8 for node GSK3B_S9 and MAP2K1_S222\n", + "looking for paths in the network with length: 9 for node GSK3B_S9 and MAP2K1_S222\n", + "looking for paths in the network with length: 10 for node GSK3B_S9 and MAP2K1_S222\n", + "i_search = 4\n", + "Looking for paths with length: 0 for node GSK3B_S9 and MAP2K1_S222\n", + "i_search = 4\n", + "Looking for paths with length: 1 for node GSK3B_S9 and MAP2K1_S222\n", + "i_search = 4\n", + "Looking for paths with length: 2 for node GSK3B_S9 and MAP2K1_S222\n", + "i_search = 4\n", + "Looking for paths with length: 3 for node GSK3B_S9 and MAP2K1_S222\n", + "i_search = 4\n", + "Looking for paths with length: 4 for node GSK3B_S9 and MAP2K1_S222\n", + "[['GSK3B_S9', 'GSK3B', 'GSK3B_Y216', 'MAP2K1', 'MAP2K1_S222']]\n", + "GSK3B_S9 GSK3B\n", + "GSK3B GSK3B_Y216\n", + "MAP2K1 GSK3B_Y216\n", + "MAP2K1_S222 MAP2K1\n", + "looking for paths in the network with length: 0 for node GSK3B_S9 and RPS6KA1_S380\n", + "looking for paths in the network with length: 1 for node GSK3B_S9 and RPS6KA1_S380\n", + "looking for paths in the network with length: 2 for node GSK3B_S9 and RPS6KA1_S380\n", + "looking for paths in the network with length: 3 for node GSK3B_S9 and RPS6KA1_S380\n", + "looking for paths in the network with length: 4 for node GSK3B_S9 and RPS6KA1_S380\n", + "looking for paths in the network with length: 5 for node GSK3B_S9 and RPS6KA1_S380\n", + "looking for paths in the network with length: 6 for node GSK3B_S9 and RPS6KA1_S380\n", + "looking for paths in the network with length: 7 for node GSK3B_S9 and RPS6KA1_S380\n", + "looking for paths in the network with length: 8 for node GSK3B_S9 and RPS6KA1_S380\n", + "looking for paths in the network with length: 9 for node GSK3B_S9 and RPS6KA1_S380\n", + "looking for paths in the network with length: 10 for node GSK3B_S9 and RPS6KA1_S380\n", + "i_search = 4\n", + "Looking for paths with length: 0 for node GSK3B_S9 and RPS6KA1_S380\n", + "i_search = 4\n", + "Looking for paths with length: 1 for node GSK3B_S9 and RPS6KA1_S380\n", + "i_search = 4\n", + "Looking for paths with length: 2 for node GSK3B_S9 and RPS6KA1_S380\n", + "[['GSK3B_S9', 'RPS6KA1', 'RPS6KA1_S380']]\n", + "RPS6KA1 GSK3B_S9\n", + "RPS6KA1 RPS6KA1_S380\n", + "looking for paths in the network with length: 0 for node GSK3B_S9 and CREB1_S133\n", + "looking for paths in the network with length: 1 for node GSK3B_S9 and CREB1_S133\n", + "looking for paths in the network with length: 2 for node GSK3B_S9 and CREB1_S133\n", + "looking for paths in the network with length: 3 for node GSK3B_S9 and CREB1_S133\n", + "looking for paths in the network with length: 4 for node GSK3B_S9 and CREB1_S133\n", + "looking for paths in the network with length: 5 for node GSK3B_S9 and CREB1_S133\n", + "looking for paths in the network with length: 6 for node GSK3B_S9 and CREB1_S133\n", + "looking for paths in the network with length: 7 for node GSK3B_S9 and CREB1_S133\n", + "looking for paths in the network with length: 8 for node GSK3B_S9 and CREB1_S133\n", + "looking for paths in the network with length: 9 for node GSK3B_S9 and CREB1_S133\n", + "looking for paths in the network with length: 10 for node GSK3B_S9 and CREB1_S133\n", + "i_search = 4\n", + "Looking for paths with length: 0 for node GSK3B_S9 and CREB1_S133\n", + "i_search = 4\n", + "Looking for paths with length: 1 for node GSK3B_S9 and CREB1_S133\n", + "i_search = 4\n", + "Looking for paths with length: 2 for node GSK3B_S9 and CREB1_S133\n", + "i_search = 4\n", + "Looking for paths with length: 3 for node GSK3B_S9 and CREB1_S133\n", + "i_search = 4\n", + "Looking for paths with length: 4 for node GSK3B_S9 and CREB1_S133\n", + "looking for paths in the network with length: 0 for node GSK3B_S9 and NFKBIA_S32\n", + "looking for paths in the network with length: 1 for node GSK3B_S9 and NFKBIA_S32\n", + "looking for paths in the network with length: 2 for node GSK3B_S9 and NFKBIA_S32\n", + "looking for paths in the network with length: 3 for node GSK3B_S9 and NFKBIA_S32\n", + "looking for paths in the network with length: 4 for node GSK3B_S9 and NFKBIA_S32\n", + "looking for paths in the network with length: 5 for node GSK3B_S9 and NFKBIA_S32\n", + "looking for paths in the network with length: 6 for node GSK3B_S9 and NFKBIA_S32\n", + "looking for paths in the network with length: 7 for node GSK3B_S9 and NFKBIA_S32\n", + "looking for paths in the network with length: 8 for node GSK3B_S9 and NFKBIA_S32\n", + "looking for paths in the network with length: 9 for node GSK3B_S9 and NFKBIA_S32\n", + "looking for paths in the network with length: 10 for node GSK3B_S9 and NFKBIA_S32\n", + "i_search = 4\n", + "Looking for paths with length: 0 for node GSK3B_S9 and NFKBIA_S32\n", + "i_search = 4\n", + "Looking for paths with length: 1 for node GSK3B_S9 and NFKBIA_S32\n", + "i_search = 4\n", + "Looking for paths with length: 2 for node GSK3B_S9 and NFKBIA_S32\n", + "i_search = 4\n", + "Looking for paths with length: 3 for node GSK3B_S9 and NFKBIA_S32\n", + "i_search = 4\n", + "Looking for paths with length: 4 for node GSK3B_S9 and NFKBIA_S32\n", + "looking for paths in the network with length: 0 for node GSK3B_S9 and NFKBIA_S36\n", + "looking for paths in the network with length: 1 for node GSK3B_S9 and NFKBIA_S36\n", + "looking for paths in the network with length: 2 for node GSK3B_S9 and NFKBIA_S36\n", + "looking for paths in the network with length: 3 for node GSK3B_S9 and NFKBIA_S36\n", + "looking for paths in the network with length: 4 for node GSK3B_S9 and NFKBIA_S36\n", + "looking for paths in the network with length: 5 for node GSK3B_S9 and NFKBIA_S36\n", + "looking for paths in the network with length: 6 for node GSK3B_S9 and NFKBIA_S36\n", + "looking for paths in the network with length: 7 for node GSK3B_S9 and NFKBIA_S36\n", + "looking for paths in the network with length: 8 for node GSK3B_S9 and NFKBIA_S36\n", + "looking for paths in the network with length: 9 for node GSK3B_S9 and NFKBIA_S36\n", + "looking for paths in the network with length: 10 for node GSK3B_S9 and NFKBIA_S36\n", + "i_search = 4\n", + "Looking for paths with length: 0 for node GSK3B_S9 and NFKBIA_S36\n", + "i_search = 4\n", + "Looking for paths with length: 1 for node GSK3B_S9 and NFKBIA_S36\n", + "i_search = 4\n", + "Looking for paths with length: 2 for node GSK3B_S9 and NFKBIA_S36\n", + "i_search = 4\n", + "Looking for paths with length: 3 for node GSK3B_S9 and NFKBIA_S36\n", + "i_search = 4\n", + "Looking for paths with length: 4 for node GSK3B_S9 and NFKBIA_S36\n", + "looking for paths in the network with length: 0 for node GSK3B_S9 and MTOR_S2448\n", + "looking for paths in the network with length: 1 for node GSK3B_S9 and MTOR_S2448\n", + "looking for paths in the network with length: 2 for node GSK3B_S9 and MTOR_S2448\n", + "looking for paths in the network with length: 3 for node GSK3B_S9 and MTOR_S2448\n", + "looking for paths in the network with length: 4 for node GSK3B_S9 and MTOR_S2448\n", + "looking for paths in the network with length: 5 for node GSK3B_S9 and MTOR_S2448\n", + "looking for paths in the network with length: 6 for node GSK3B_S9 and MTOR_S2448\n", + "looking for paths in the network with length: 7 for node GSK3B_S9 and MTOR_S2448\n", + "looking for paths in the network with length: 8 for node GSK3B_S9 and MTOR_S2448\n", + "looking for paths in the network with length: 9 for node GSK3B_S9 and MTOR_S2448\n", + "looking for paths in the network with length: 10 for node GSK3B_S9 and MTOR_S2448\n", + "i_search = 4\n", + "Looking for paths with length: 0 for node GSK3B_S9 and MTOR_S2448\n", + "i_search = 4\n", + "Looking for paths with length: 1 for node GSK3B_S9 and MTOR_S2448\n", + "i_search = 4\n", + "Looking for paths with length: 2 for node GSK3B_S9 and MTOR_S2448\n", + "i_search = 4\n", + "Looking for paths with length: 3 for node GSK3B_S9 and MTOR_S2448\n", + "i_search = 4\n", + "Looking for paths with length: 4 for node GSK3B_S9 and MTOR_S2448\n", + "[['GSK3B_S9', 'RPS6KB1', 'RPS6KB1_T412', 'MTOR', 'MTOR_S2448'], ['GSK3B_S9', 'RPS6KB1', 'RPS6KB1_S434', 'MTOR', 'MTOR_S2448'], ['GSK3B_S9', 'RPS6KB1', 'RPS6KB1_T389', 'MTOR', 'MTOR_S2448'], ['GSK3B_S9', 'RPS6KB1', 'RPS6KB1_S394', 'MTOR', 'MTOR_S2448'], ['GSK3B_S9', 'EEF2K', 'EEF2K_S74', 'MTOR', 'MTOR_S2448'], ['GSK3B_S9', 'EEF2K', 'EEF2K_S72', 'MTOR', 'MTOR_S2448'], ['GSK3B_S9', 'AKT1', 'AKT1_S473', 'MTOR', 'MTOR_S2448'], ['GSK3B_S9', 'AKT1', 'AKT1_T450', 'MTOR', 'MTOR_S2448'], ['GSK3B_S9', 'SGK1', 'SGK1_S422', 'MTOR', 'MTOR_S2448'], ['GSK3B_S9', 'PRKCB', 'PRKCB_T642', 'MTOR', 'MTOR_S2448']]\n", + "RPS6KB1 GSK3B_S9\n", + "RPS6KB1 RPS6KB1_T412\n", + "MTOR RPS6KB1_T412\n", + "MTOR MTOR_S2448\n", + "RPS6KB1 GSK3B_S9\n", + "RPS6KB1_S434 RPS6KB1\n", + "MTOR RPS6KB1_S434\n", + "MTOR MTOR_S2448\n", + "RPS6KB1 GSK3B_S9\n", + "RPS6KB1_T389 RPS6KB1\n", + "MTOR RPS6KB1_T389\n", + "MTOR MTOR_S2448\n", + "RPS6KB1 GSK3B_S9\n", + "RPS6KB1_S394 RPS6KB1\n", + "MTOR RPS6KB1_S394\n", + "MTOR MTOR_S2448\n", + "EEF2K GSK3B_S9\n", + "EEF2K_S74 EEF2K\n", + "MTOR EEF2K_S74\n", + "MTOR MTOR_S2448\n", + "EEF2K GSK3B_S9\n", + "EEF2K_S72 EEF2K\n", + "MTOR EEF2K_S72\n", + "MTOR MTOR_S2448\n", + "AKT1 GSK3B_S9\n", + "AKT1_S473 AKT1\n", + "MTOR AKT1_S473\n", + "MTOR MTOR_S2448\n", + "AKT1 GSK3B_S9\n", + "AKT1_T450 AKT1\n", + "MTOR AKT1_T450\n", + "MTOR MTOR_S2448\n", + "SGK1 GSK3B_S9\n", + "SGK1 SGK1_S422\n", + "MTOR SGK1_S422\n", + "MTOR MTOR_S2448\n", + "PRKCB GSK3B_S9\n", + "PRKCB_T642 PRKCB\n", + "MTOR PRKCB_T642\n", + "MTOR MTOR_S2448\n", + "looking for paths in the network with length: 0 for node GSK3B_S9 and JUN_S63\n", + "looking for paths in the network with length: 1 for node GSK3B_S9 and JUN_S63\n", + "looking for paths in the network with length: 2 for node GSK3B_S9 and JUN_S63\n", + "looking for paths in the network with length: 3 for node GSK3B_S9 and JUN_S63\n", + "looking for paths in the network with length: 4 for node GSK3B_S9 and JUN_S63\n", + "looking for paths in the network with length: 5 for node GSK3B_S9 and JUN_S63\n", + "looking for paths in the network with length: 6 for node GSK3B_S9 and JUN_S63\n", + "looking for paths in the network with length: 7 for node GSK3B_S9 and JUN_S63\n", + "looking for paths in the network with length: 8 for node GSK3B_S9 and JUN_S63\n", + "looking for paths in the network with length: 9 for node GSK3B_S9 and JUN_S63\n", + "looking for paths in the network with length: 10 for node GSK3B_S9 and JUN_S63\n", + "i_search = 4\n", + "Looking for paths with length: 0 for node GSK3B_S9 and JUN_S63\n", + "i_search = 4\n", + "Looking for paths with length: 1 for node GSK3B_S9 and JUN_S63\n", + "i_search = 4\n", + "Looking for paths with length: 2 for node GSK3B_S9 and JUN_S63\n", + "i_search = 4\n", + "Looking for paths with length: 3 for node GSK3B_S9 and JUN_S63\n", + "i_search = 4\n", + "Looking for paths with length: 4 for node GSK3B_S9 and JUN_S63\n", + "looking for paths in the network with length: 0 for node GSK3B_S9 and EGFR_Y1068\n", + "looking for paths in the network with length: 1 for node GSK3B_S9 and EGFR_Y1068\n", + "looking for paths in the network with length: 2 for node GSK3B_S9 and EGFR_Y1068\n", + "looking for paths in the network with length: 3 for node GSK3B_S9 and EGFR_Y1068\n", + "looking for paths in the network with length: 4 for node GSK3B_S9 and EGFR_Y1068\n", + "looking for paths in the network with length: 5 for node GSK3B_S9 and EGFR_Y1068\n", + "looking for paths in the network with length: 6 for node GSK3B_S9 and EGFR_Y1068\n", + "looking for paths in the network with length: 7 for node GSK3B_S9 and EGFR_Y1068\n", + "looking for paths in the network with length: 8 for node GSK3B_S9 and EGFR_Y1068\n", + "looking for paths in the network with length: 9 for node GSK3B_S9 and EGFR_Y1068\n", + "looking for paths in the network with length: 10 for node GSK3B_S9 and EGFR_Y1068\n", + "i_search = 4\n", + "Looking for paths with length: 0 for node GSK3B_S9 and EGFR_Y1068\n", + "i_search = 4\n", + "Looking for paths with length: 1 for node GSK3B_S9 and EGFR_Y1068\n", + "i_search = 4\n", + "Looking for paths with length: 2 for node GSK3B_S9 and EGFR_Y1068\n", + "i_search = 4\n", + "Looking for paths with length: 3 for node GSK3B_S9 and EGFR_Y1068\n", + "i_search = 4\n", + "Looking for paths with length: 4 for node GSK3B_S9 and EGFR_Y1068\n", + "looking for paths in the network with length: 0 for node GSK3B_S9 and MAPK3_T202\n", + "looking for paths in the network with length: 1 for node GSK3B_S9 and MAPK3_T202\n", + "looking for paths in the network with length: 2 for node GSK3B_S9 and MAPK3_T202\n", + "looking for paths in the network with length: 3 for node GSK3B_S9 and MAPK3_T202\n", + "looking for paths in the network with length: 4 for node GSK3B_S9 and MAPK3_T202\n", + "looking for paths in the network with length: 5 for node GSK3B_S9 and MAPK3_T202\n", + "looking for paths in the network with length: 6 for node GSK3B_S9 and MAPK3_T202\n", + "looking for paths in the network with length: 7 for node GSK3B_S9 and MAPK3_T202\n", + "looking for paths in the network with length: 8 for node GSK3B_S9 and MAPK3_T202\n", + "looking for paths in the network with length: 9 for node GSK3B_S9 and MAPK3_T202\n", + "looking for paths in the network with length: 10 for node GSK3B_S9 and MAPK3_T202\n", + "i_search = 4\n", + "Looking for paths with length: 0 for node GSK3B_S9 and MAPK3_T202\n", + "i_search = 4\n", + "Looking for paths with length: 1 for node GSK3B_S9 and MAPK3_T202\n", + "i_search = 4\n", + "Looking for paths with length: 2 for node GSK3B_S9 and MAPK3_T202\n", + "i_search = 4\n", + "Looking for paths with length: 3 for node GSK3B_S9 and MAPK3_T202\n", + "i_search = 4\n", + "Looking for paths with length: 4 for node GSK3B_S9 and MAPK3_T202\n", + "[['GSK3B_S9', 'GSK3B', 'GSK3B_T43', 'MAPK3', 'MAPK3_T202'], ['GSK3B_S9', 'RPS6KA1', 'RPS6KA1_S380', 'MAPK3', 'MAPK3_T202']]\n", + "GSK3B_S9 GSK3B\n", + "GSK3B_T43 GSK3B\n", + "MAPK3 GSK3B_T43\n", + "MAPK3_T202 MAPK3\n", + "RPS6KA1 GSK3B_S9\n", + "RPS6KA1 RPS6KA1_S380\n", + "MAPK3 RPS6KA1_S380\n", + "MAPK3_T202 MAPK3\n", + "looking for paths in the network with length: 0 for node GSK3B_S9 and MAPK3_Y204\n", + "looking for paths in the network with length: 1 for node GSK3B_S9 and MAPK3_Y204\n", + "looking for paths in the network with length: 2 for node GSK3B_S9 and MAPK3_Y204\n", + "looking for paths in the network with length: 3 for node GSK3B_S9 and MAPK3_Y204\n", + "looking for paths in the network with length: 4 for node GSK3B_S9 and MAPK3_Y204\n", + "looking for paths in the network with length: 5 for node GSK3B_S9 and MAPK3_Y204\n", + "looking for paths in the network with length: 6 for node GSK3B_S9 and MAPK3_Y204\n", + "looking for paths in the network with length: 7 for node GSK3B_S9 and MAPK3_Y204\n", + "looking for paths in the network with length: 8 for node GSK3B_S9 and MAPK3_Y204\n", + "looking for paths in the network with length: 9 for node GSK3B_S9 and MAPK3_Y204\n", + "looking for paths in the network with length: 10 for node GSK3B_S9 and MAPK3_Y204\n", + "i_search = 4\n", + "Looking for paths with length: 0 for node GSK3B_S9 and MAPK3_Y204\n", + "i_search = 4\n", + "Looking for paths with length: 1 for node GSK3B_S9 and MAPK3_Y204\n", + "i_search = 4\n", + "Looking for paths with length: 2 for node GSK3B_S9 and MAPK3_Y204\n", + "i_search = 4\n", + "Looking for paths with length: 3 for node GSK3B_S9 and MAPK3_Y204\n", + "i_search = 4\n", + "Looking for paths with length: 4 for node GSK3B_S9 and MAPK3_Y204\n", + "[['GSK3B_S9', 'GSK3B', 'GSK3B_T43', 'MAPK3', 'MAPK3_Y204'], ['GSK3B_S9', 'RPS6KA1', 'RPS6KA1_S380', 'MAPK3', 'MAPK3_Y204']]\n", + "GSK3B_S9 GSK3B\n", + "GSK3B_T43 GSK3B\n", + "MAPK3 GSK3B_T43\n", + "MAPK3 MAPK3_Y204\n", + "RPS6KA1 GSK3B_S9\n", + "RPS6KA1 RPS6KA1_S380\n", + "MAPK3 RPS6KA1_S380\n", + "MAPK3 MAPK3_Y204\n", + "looking for paths in the network with length: 0 for node GSK3B_S9 and PTPN11_Y542\n", + "looking for paths in the network with length: 1 for node GSK3B_S9 and PTPN11_Y542\n", + "looking for paths in the network with length: 2 for node GSK3B_S9 and PTPN11_Y542\n", + "looking for paths in the network with length: 3 for node GSK3B_S9 and PTPN11_Y542\n", + "looking for paths in the network with length: 4 for node GSK3B_S9 and PTPN11_Y542\n", + "looking for paths in the network with length: 5 for node GSK3B_S9 and PTPN11_Y542\n", + "looking for paths in the network with length: 6 for node GSK3B_S9 and PTPN11_Y542\n", + "looking for paths in the network with length: 7 for node GSK3B_S9 and PTPN11_Y542\n", + "looking for paths in the network with length: 8 for node GSK3B_S9 and PTPN11_Y542\n", + "looking for paths in the network with length: 9 for node GSK3B_S9 and PTPN11_Y542\n", + "looking for paths in the network with length: 10 for node GSK3B_S9 and PTPN11_Y542\n", + "i_search = 4\n", + "Looking for paths with length: 0 for node GSK3B_S9 and PTPN11_Y542\n", + "i_search = 4\n", + "Looking for paths with length: 1 for node GSK3B_S9 and PTPN11_Y542\n", + "i_search = 4\n", + "Looking for paths with length: 2 for node GSK3B_S9 and PTPN11_Y542\n", + "i_search = 4\n", + "Looking for paths with length: 3 for node GSK3B_S9 and PTPN11_Y542\n", + "i_search = 4\n", + "Looking for paths with length: 4 for node GSK3B_S9 and PTPN11_Y542\n", + "looking for paths in the network with length: 0 for node GSK3B_S9 and STAT3_Y705\n", + "looking for paths in the network with length: 1 for node GSK3B_S9 and STAT3_Y705\n", + "looking for paths in the network with length: 2 for node GSK3B_S9 and STAT3_Y705\n", + "looking for paths in the network with length: 3 for node GSK3B_S9 and STAT3_Y705\n", + "looking for paths in the network with length: 4 for node GSK3B_S9 and STAT3_Y705\n", + "looking for paths in the network with length: 5 for node GSK3B_S9 and STAT3_Y705\n", + "looking for paths in the network with length: 6 for node GSK3B_S9 and STAT3_Y705\n", + "looking for paths in the network with length: 7 for node GSK3B_S9 and STAT3_Y705\n", + "looking for paths in the network with length: 8 for node GSK3B_S9 and STAT3_Y705\n", + "looking for paths in the network with length: 9 for node GSK3B_S9 and STAT3_Y705\n", + "looking for paths in the network with length: 10 for node GSK3B_S9 and STAT3_Y705\n", + "i_search = 4\n", + "Looking for paths with length: 0 for node GSK3B_S9 and STAT3_Y705\n", + "i_search = 4\n", + "Looking for paths with length: 1 for node GSK3B_S9 and STAT3_Y705\n", + "i_search = 4\n", + "Looking for paths with length: 2 for node GSK3B_S9 and STAT3_Y705\n", + "i_search = 4\n", + "Looking for paths with length: 3 for node GSK3B_S9 and STAT3_Y705\n", + "i_search = 4\n", + "Looking for paths with length: 4 for node GSK3B_S9 and STAT3_Y705\n", + "[['GSK3B_S9', 'GSK3B', 'SRC_S493', 'SRC', 'STAT3_Y705'], ['GSK3B_S9', 'GSK3B', 'SRC_S51', 'SRC', 'STAT3_Y705'], ['GSK3B_S9', 'GSK3B', 'SRC_Y419', 'SRC', 'STAT3_Y705'], ['GSK3B_S9', 'GSK3B', 'SRC_S43', 'SRC', 'STAT3_Y705']]\n", + "GSK3B_S9 GSK3B\n", + "GSK3B SRC_S493\n", + "SRC_S493 SRC\n", + "SRC STAT3_Y705\n", + "GSK3B_S9 GSK3B\n", + "GSK3B SRC_S51\n", + "SRC_S51 SRC\n", + "SRC STAT3_Y705\n", + "GSK3B_S9 GSK3B\n", + "GSK3B SRC_Y419\n", + "SRC_Y419 SRC\n", + "SRC STAT3_Y705\n", + "GSK3B_S9 GSK3B\n", + "GSK3B SRC_S43\n", + "SRC_S43 SRC\n", + "SRC STAT3_Y705\n", + "looking for paths in the network with length: 0 for node GSK3B_S9 and CHEK2_T68\n", + "looking for paths in the network with length: 1 for node GSK3B_S9 and CHEK2_T68\n", + "looking for paths in the network with length: 2 for node GSK3B_S9 and CHEK2_T68\n", + "looking for paths in the network with length: 3 for node GSK3B_S9 and CHEK2_T68\n", + "looking for paths in the network with length: 4 for node GSK3B_S9 and CHEK2_T68\n", + "looking for paths in the network with length: 5 for node GSK3B_S9 and CHEK2_T68\n", + "looking for paths in the network with length: 6 for node GSK3B_S9 and CHEK2_T68\n", + "looking for paths in the network with length: 7 for node GSK3B_S9 and CHEK2_T68\n", + "looking for paths in the network with length: 8 for node GSK3B_S9 and CHEK2_T68\n", + "looking for paths in the network with length: 9 for node GSK3B_S9 and CHEK2_T68\n", + "looking for paths in the network with length: 10 for node GSK3B_S9 and CHEK2_T68\n", + "i_search = 4\n", + "Looking for paths with length: 0 for node GSK3B_S9 and CHEK2_T68\n", + "i_search = 4\n", + "Looking for paths with length: 1 for node GSK3B_S9 and CHEK2_T68\n", + "i_search = 4\n", + "Looking for paths with length: 2 for node GSK3B_S9 and CHEK2_T68\n", + "i_search = 4\n", + "Looking for paths with length: 3 for node GSK3B_S9 and CHEK2_T68\n", + "i_search = 4\n", + "Looking for paths with length: 4 for node GSK3B_S9 and CHEK2_T68\n", + "looking for paths in the network with length: 0 for node GSK3B_S9 and RELA_S536\n", + "looking for paths in the network with length: 1 for node GSK3B_S9 and RELA_S536\n", + "looking for paths in the network with length: 2 for node GSK3B_S9 and RELA_S536\n", + "looking for paths in the network with length: 3 for node GSK3B_S9 and RELA_S536\n", + "looking for paths in the network with length: 4 for node GSK3B_S9 and RELA_S536\n", + "looking for paths in the network with length: 5 for node GSK3B_S9 and RELA_S536\n", + "looking for paths in the network with length: 6 for node GSK3B_S9 and RELA_S536\n", + "looking for paths in the network with length: 7 for node GSK3B_S9 and RELA_S536\n", + "looking for paths in the network with length: 8 for node GSK3B_S9 and RELA_S536\n", + "looking for paths in the network with length: 9 for node GSK3B_S9 and RELA_S536\n", + "looking for paths in the network with length: 10 for node GSK3B_S9 and RELA_S536\n", + "i_search = 4\n", + "Looking for paths with length: 0 for node GSK3B_S9 and RELA_S536\n", + "i_search = 4\n", + "Looking for paths with length: 1 for node GSK3B_S9 and RELA_S536\n", + "i_search = 4\n", + "Looking for paths with length: 2 for node GSK3B_S9 and RELA_S536\n", + "i_search = 4\n", + "Looking for paths with length: 3 for node GSK3B_S9 and RELA_S536\n", + "i_search = 4\n", + "Looking for paths with length: 4 for node GSK3B_S9 and RELA_S536\n", + "[['GSK3B_S9', 'GSK3B', 'TBK1_S172', 'TBK1', 'RELA_S536']]\n", + "GSK3B_S9 GSK3B\n", + "GSK3B TBK1_S172\n", + "TBK1_S172 TBK1\n", + "TBK1 RELA_S536\n", + "looking for paths in the network with length: 0 for node GSK3B_S9 and MARCKS_S170\n", + "looking for paths in the network with length: 1 for node GSK3B_S9 and MARCKS_S170\n", + "looking for paths in the network with length: 2 for node GSK3B_S9 and MARCKS_S170\n", + "looking for paths in the network with length: 3 for node GSK3B_S9 and MARCKS_S170\n", + "looking for paths in the network with length: 4 for node GSK3B_S9 and MARCKS_S170\n", + "looking for paths in the network with length: 5 for node GSK3B_S9 and MARCKS_S170\n", + "looking for paths in the network with length: 6 for node GSK3B_S9 and MARCKS_S170\n", + "looking for paths in the network with length: 7 for node GSK3B_S9 and MARCKS_S170\n", + "looking for paths in the network with length: 8 for node GSK3B_S9 and MARCKS_S170\n", + "looking for paths in the network with length: 9 for node GSK3B_S9 and MARCKS_S170\n", + "looking for paths in the network with length: 10 for node GSK3B_S9 and MARCKS_S170\n", + "i_search = 4\n", + "Looking for paths with length: 0 for node GSK3B_S9 and MARCKS_S170\n", + "i_search = 4\n", + "Looking for paths with length: 1 for node GSK3B_S9 and MARCKS_S170\n", + "i_search = 4\n", + "Looking for paths with length: 2 for node GSK3B_S9 and MARCKS_S170\n", + "i_search = 4\n", + "Looking for paths with length: 3 for node GSK3B_S9 and MARCKS_S170\n", + "i_search = 4\n", + "Looking for paths with length: 4 for node GSK3B_S9 and MARCKS_S170\n", + "looking for paths in the network with length: 0 for node GSK3B_S9 and SMAD3\n", + "looking for paths in the network with length: 1 for node GSK3B_S9 and SMAD3\n", + "looking for paths in the network with length: 2 for node GSK3B_S9 and SMAD3\n", + "looking for paths in the network with length: 3 for node GSK3B_S9 and SMAD3\n", + "looking for paths in the network with length: 4 for node GSK3B_S9 and SMAD3\n", + "looking for paths in the network with length: 5 for node GSK3B_S9 and SMAD3\n", + "looking for paths in the network with length: 6 for node GSK3B_S9 and SMAD3\n", + "looking for paths in the network with length: 7 for node GSK3B_S9 and SMAD3\n", + "looking for paths in the network with length: 8 for node GSK3B_S9 and SMAD3\n", + "looking for paths in the network with length: 9 for node GSK3B_S9 and SMAD3\n", + "looking for paths in the network with length: 10 for node GSK3B_S9 and SMAD3\n", + "i_search = 4\n", + "Looking for paths with length: 0 for node GSK3B_S9 and SMAD3\n", + "i_search = 4\n", + "Looking for paths with length: 1 for node GSK3B_S9 and SMAD3\n", + "i_search = 4\n", + "Looking for paths with length: 2 for node GSK3B_S9 and SMAD3\n", + "i_search = 4\n", + "Looking for paths with length: 3 for node GSK3B_S9 and SMAD3\n", + "i_search = 4\n", + "Looking for paths with length: 4 for node GSK3B_S9 and SMAD3\n", + "looking for paths in the network with length: 0 for node GSK3B_S9 and TP53\n", + "looking for paths in the network with length: 1 for node GSK3B_S9 and TP53\n", + "looking for paths in the network with length: 2 for node GSK3B_S9 and TP53\n", + "looking for paths in the network with length: 3 for node GSK3B_S9 and TP53\n", + "looking for paths in the network with length: 4 for node GSK3B_S9 and TP53\n", + "looking for paths in the network with length: 5 for node GSK3B_S9 and TP53\n", + "looking for paths in the network with length: 6 for node GSK3B_S9 and TP53\n", + "looking for paths in the network with length: 7 for node GSK3B_S9 and TP53\n", + "looking for paths in the network with length: 8 for node GSK3B_S9 and TP53\n", + "looking for paths in the network with length: 9 for node GSK3B_S9 and TP53\n", + "looking for paths in the network with length: 10 for node GSK3B_S9 and TP53\n", + "i_search = 4\n", + "Looking for paths with length: 0 for node GSK3B_S9 and TP53\n", + "i_search = 4\n", + "Looking for paths with length: 1 for node GSK3B_S9 and TP53\n", + "i_search = 4\n", + "Looking for paths with length: 2 for node GSK3B_S9 and TP53\n", + "i_search = 4\n", + "Looking for paths with length: 3 for node GSK3B_S9 and TP53\n", + "i_search = 4\n", + "Looking for paths with length: 4 for node GSK3B_S9 and TP53\n", + "looking for paths in the network with length: 0 for node GSK3B_S9 and AKT1S1\n", + "looking for paths in the network with length: 1 for node GSK3B_S9 and AKT1S1\n", + "looking for paths in the network with length: 2 for node GSK3B_S9 and AKT1S1\n", + "looking for paths in the network with length: 3 for node GSK3B_S9 and AKT1S1\n", + "looking for paths in the network with length: 4 for node GSK3B_S9 and AKT1S1\n", + "looking for paths in the network with length: 5 for node GSK3B_S9 and AKT1S1\n", + "looking for paths in the network with length: 6 for node GSK3B_S9 and AKT1S1\n", + "looking for paths in the network with length: 7 for node GSK3B_S9 and AKT1S1\n", + "looking for paths in the network with length: 8 for node GSK3B_S9 and AKT1S1\n", + "looking for paths in the network with length: 9 for node GSK3B_S9 and AKT1S1\n", + "looking for paths in the network with length: 10 for node GSK3B_S9 and AKT1S1\n", + "i_search = 4\n", + "Looking for paths with length: 0 for node GSK3B_S9 and AKT1S1\n", + "i_search = 4\n", + "Looking for paths with length: 1 for node GSK3B_S9 and AKT1S1\n", + "i_search = 4\n", + "Looking for paths with length: 2 for node GSK3B_S9 and AKT1S1\n", + "i_search = 4\n", + "Looking for paths with length: 3 for node GSK3B_S9 and AKT1S1\n", + "i_search = 4\n", + "Looking for paths with length: 4 for node GSK3B_S9 and AKT1S1\n", + "looking for paths in the network with length: 0 for node GSK3B_S9 and GSK3B\n", + "looking for paths in the network with length: 1 for node GSK3B_S9 and GSK3B\n", + "looking for paths in the network with length: 2 for node GSK3B_S9 and GSK3B\n", + "looking for paths in the network with length: 3 for node GSK3B_S9 and GSK3B\n", + "looking for paths in the network with length: 4 for node GSK3B_S9 and GSK3B\n", + "looking for paths in the network with length: 5 for node GSK3B_S9 and GSK3B\n", + "looking for paths in the network with length: 6 for node GSK3B_S9 and GSK3B\n", + "looking for paths in the network with length: 7 for node GSK3B_S9 and GSK3B\n", + "looking for paths in the network with length: 8 for node GSK3B_S9 and GSK3B\n", + "looking for paths in the network with length: 9 for node GSK3B_S9 and GSK3B\n", + "looking for paths in the network with length: 10 for node GSK3B_S9 and GSK3B\n", + "i_search = 4\n", + "Looking for paths with length: 0 for node GSK3B_S9 and GSK3B\n", + "i_search = 4\n", + "Looking for paths with length: 1 for node GSK3B_S9 and GSK3B\n", + "i_search = 4\n", + "Looking for paths with length: 2 for node GSK3B_S9 and GSK3B\n", + "i_search = 4\n", + "Looking for paths with length: 3 for node GSK3B_S9 and GSK3B\n", + "i_search = 4\n", + "Looking for paths with length: 4 for node GSK3B_S9 and GSK3B\n", + "looking for paths in the network with length: 0 for node GSK3B_S9 and AKT1\n", + "looking for paths in the network with length: 1 for node GSK3B_S9 and AKT1\n", + "looking for paths in the network with length: 2 for node GSK3B_S9 and AKT1\n", + "looking for paths in the network with length: 3 for node GSK3B_S9 and AKT1\n", + "looking for paths in the network with length: 4 for node GSK3B_S9 and AKT1\n", + "looking for paths in the network with length: 5 for node GSK3B_S9 and AKT1\n", + "looking for paths in the network with length: 6 for node GSK3B_S9 and AKT1\n", + "looking for paths in the network with length: 7 for node GSK3B_S9 and AKT1\n", + "looking for paths in the network with length: 8 for node GSK3B_S9 and AKT1\n", + "looking for paths in the network with length: 9 for node GSK3B_S9 and AKT1\n", + "looking for paths in the network with length: 10 for node GSK3B_S9 and AKT1\n", + "i_search = 4\n", + "Looking for paths with length: 0 for node GSK3B_S9 and AKT1\n", + "i_search = 4\n", + "Looking for paths with length: 1 for node GSK3B_S9 and AKT1\n", + "i_search = 4\n", + "Looking for paths with length: 2 for node GSK3B_S9 and AKT1\n", + "i_search = 4\n", + "Looking for paths with length: 3 for node GSK3B_S9 and AKT1\n", + "i_search = 4\n", + "Looking for paths with length: 4 for node GSK3B_S9 and AKT1\n", + "looking for paths in the network with length: 0 for node GSK3B_S9 and HSPB1\n", + "looking for paths in the network with length: 1 for node GSK3B_S9 and HSPB1\n", + "looking for paths in the network with length: 2 for node GSK3B_S9 and HSPB1\n", + "looking for paths in the network with length: 3 for node GSK3B_S9 and HSPB1\n", + "looking for paths in the network with length: 4 for node GSK3B_S9 and HSPB1\n", + "looking for paths in the network with length: 5 for node GSK3B_S9 and HSPB1\n", + "looking for paths in the network with length: 6 for node GSK3B_S9 and HSPB1\n", + "looking for paths in the network with length: 7 for node GSK3B_S9 and HSPB1\n", + "looking for paths in the network with length: 8 for node GSK3B_S9 and HSPB1\n", + "looking for paths in the network with length: 9 for node GSK3B_S9 and HSPB1\n", + "looking for paths in the network with length: 10 for node GSK3B_S9 and HSPB1\n", + "i_search = 4\n", + "Looking for paths with length: 0 for node GSK3B_S9 and HSPB1\n", + "i_search = 4\n", + "Looking for paths with length: 1 for node GSK3B_S9 and HSPB1\n", + "i_search = 4\n", + "Looking for paths with length: 2 for node GSK3B_S9 and HSPB1\n", + "i_search = 4\n", + "Looking for paths with length: 3 for node GSK3B_S9 and HSPB1\n", + "i_search = 4\n", + "Looking for paths with length: 4 for node GSK3B_S9 and HSPB1\n", + "looking for paths in the network with length: 0 for node GSK3B_S9 and MAPK14\n", + "looking for paths in the network with length: 1 for node GSK3B_S9 and MAPK14\n", + "looking for paths in the network with length: 2 for node GSK3B_S9 and MAPK14\n", + "looking for paths in the network with length: 3 for node GSK3B_S9 and MAPK14\n", + "looking for paths in the network with length: 4 for node GSK3B_S9 and MAPK14\n", + "looking for paths in the network with length: 5 for node GSK3B_S9 and MAPK14\n", + "looking for paths in the network with length: 6 for node GSK3B_S9 and MAPK14\n", + "looking for paths in the network with length: 7 for node GSK3B_S9 and MAPK14\n", + "looking for paths in the network with length: 8 for node GSK3B_S9 and MAPK14\n", + "looking for paths in the network with length: 9 for node GSK3B_S9 and MAPK14\n", + "looking for paths in the network with length: 10 for node GSK3B_S9 and MAPK14\n", + "i_search = 4\n", + "Looking for paths with length: 0 for node GSK3B_S9 and MAPK14\n", + "i_search = 4\n", + "Looking for paths with length: 1 for node GSK3B_S9 and MAPK14\n", + "i_search = 4\n", + "Looking for paths with length: 2 for node GSK3B_S9 and MAPK14\n", + "i_search = 4\n", + "Looking for paths with length: 3 for node GSK3B_S9 and MAPK14\n", + "i_search = 4\n", + "Looking for paths with length: 4 for node GSK3B_S9 and MAPK14\n", + "looking for paths in the network with length: 0 for node GSK3B_S9 and MAP2K1\n", + "looking for paths in the network with length: 1 for node GSK3B_S9 and MAP2K1\n", + "looking for paths in the network with length: 2 for node GSK3B_S9 and MAP2K1\n", + "looking for paths in the network with length: 3 for node GSK3B_S9 and MAP2K1\n", + "looking for paths in the network with length: 4 for node GSK3B_S9 and MAP2K1\n", + "looking for paths in the network with length: 5 for node GSK3B_S9 and MAP2K1\n", + "looking for paths in the network with length: 6 for node GSK3B_S9 and MAP2K1\n", + "looking for paths in the network with length: 7 for node GSK3B_S9 and MAP2K1\n", + "looking for paths in the network with length: 8 for node GSK3B_S9 and MAP2K1\n", + "looking for paths in the network with length: 9 for node GSK3B_S9 and MAP2K1\n", + "looking for paths in the network with length: 10 for node GSK3B_S9 and MAP2K1\n", + "i_search = 4\n", + "Looking for paths with length: 0 for node GSK3B_S9 and MAP2K1\n", + "i_search = 4\n", + "Looking for paths with length: 1 for node GSK3B_S9 and MAP2K1\n", + "i_search = 4\n", + "Looking for paths with length: 2 for node GSK3B_S9 and MAP2K1\n", + "i_search = 4\n", + "Looking for paths with length: 3 for node GSK3B_S9 and MAP2K1\n", + "i_search = 4\n", + "Looking for paths with length: 4 for node GSK3B_S9 and MAP2K1\n", + "looking for paths in the network with length: 0 for node GSK3B_S9 and RPS6KA1\n", + "looking for paths in the network with length: 1 for node GSK3B_S9 and RPS6KA1\n", + "looking for paths in the network with length: 2 for node GSK3B_S9 and RPS6KA1\n", + "looking for paths in the network with length: 3 for node GSK3B_S9 and RPS6KA1\n", + "looking for paths in the network with length: 4 for node GSK3B_S9 and RPS6KA1\n", + "looking for paths in the network with length: 5 for node GSK3B_S9 and RPS6KA1\n", + "looking for paths in the network with length: 6 for node GSK3B_S9 and RPS6KA1\n", + "looking for paths in the network with length: 7 for node GSK3B_S9 and RPS6KA1\n", + "looking for paths in the network with length: 8 for node GSK3B_S9 and RPS6KA1\n", + "looking for paths in the network with length: 9 for node GSK3B_S9 and RPS6KA1\n", + "looking for paths in the network with length: 10 for node GSK3B_S9 and RPS6KA1\n", + "i_search = 4\n", + "Looking for paths with length: 0 for node GSK3B_S9 and RPS6KA1\n", + "i_search = 4\n", + "Looking for paths with length: 1 for node GSK3B_S9 and RPS6KA1\n", + "i_search = 4\n", + "Looking for paths with length: 2 for node GSK3B_S9 and RPS6KA1\n", + "i_search = 4\n", + "Looking for paths with length: 3 for node GSK3B_S9 and RPS6KA1\n", + "i_search = 4\n", + "Looking for paths with length: 4 for node GSK3B_S9 and RPS6KA1\n", + "looking for paths in the network with length: 0 for node GSK3B_S9 and CREB1\n", + "looking for paths in the network with length: 1 for node GSK3B_S9 and CREB1\n", + "looking for paths in the network with length: 2 for node GSK3B_S9 and CREB1\n", + "looking for paths in the network with length: 3 for node GSK3B_S9 and CREB1\n", + "looking for paths in the network with length: 4 for node GSK3B_S9 and CREB1\n", + "looking for paths in the network with length: 5 for node GSK3B_S9 and CREB1\n", + "looking for paths in the network with length: 6 for node GSK3B_S9 and CREB1\n", + "looking for paths in the network with length: 7 for node GSK3B_S9 and CREB1\n", + "looking for paths in the network with length: 8 for node GSK3B_S9 and CREB1\n", + "looking for paths in the network with length: 9 for node GSK3B_S9 and CREB1\n", + "looking for paths in the network with length: 10 for node GSK3B_S9 and CREB1\n", + "i_search = 4\n", + "Looking for paths with length: 0 for node GSK3B_S9 and CREB1\n", + "i_search = 4\n", + "Looking for paths with length: 1 for node GSK3B_S9 and CREB1\n", + "i_search = 4\n", + "Looking for paths with length: 2 for node GSK3B_S9 and CREB1\n", + "i_search = 4\n", + "Looking for paths with length: 3 for node GSK3B_S9 and CREB1\n", + "i_search = 4\n", + "Looking for paths with length: 4 for node GSK3B_S9 and CREB1\n", + "looking for paths in the network with length: 0 for node GSK3B_S9 and NFKBIA\n", + "looking for paths in the network with length: 1 for node GSK3B_S9 and NFKBIA\n", + "looking for paths in the network with length: 2 for node GSK3B_S9 and NFKBIA\n", + "looking for paths in the network with length: 3 for node GSK3B_S9 and NFKBIA\n", + "looking for paths in the network with length: 4 for node GSK3B_S9 and NFKBIA\n", + "looking for paths in the network with length: 5 for node GSK3B_S9 and NFKBIA\n", + "looking for paths in the network with length: 6 for node GSK3B_S9 and NFKBIA\n", + "looking for paths in the network with length: 7 for node GSK3B_S9 and NFKBIA\n", + "looking for paths in the network with length: 8 for node GSK3B_S9 and NFKBIA\n", + "looking for paths in the network with length: 9 for node GSK3B_S9 and NFKBIA\n", + "looking for paths in the network with length: 10 for node GSK3B_S9 and NFKBIA\n", + "i_search = 4\n", + "Looking for paths with length: 0 for node GSK3B_S9 and NFKBIA\n", + "i_search = 4\n", + "Looking for paths with length: 1 for node GSK3B_S9 and NFKBIA\n", + "i_search = 4\n", + "Looking for paths with length: 2 for node GSK3B_S9 and NFKBIA\n", + "i_search = 4\n", + "Looking for paths with length: 3 for node GSK3B_S9 and NFKBIA\n", + "i_search = 4\n", + "Looking for paths with length: 4 for node GSK3B_S9 and NFKBIA\n", + "looking for paths in the network with length: 0 for node GSK3B_S9 and MTOR\n", + "looking for paths in the network with length: 1 for node GSK3B_S9 and MTOR\n", + "looking for paths in the network with length: 2 for node GSK3B_S9 and MTOR\n", + "looking for paths in the network with length: 3 for node GSK3B_S9 and MTOR\n", + "looking for paths in the network with length: 4 for node GSK3B_S9 and MTOR\n", + "looking for paths in the network with length: 5 for node GSK3B_S9 and MTOR\n", + "looking for paths in the network with length: 6 for node GSK3B_S9 and MTOR\n", + "looking for paths in the network with length: 7 for node GSK3B_S9 and MTOR\n", + "looking for paths in the network with length: 8 for node GSK3B_S9 and MTOR\n", + "looking for paths in the network with length: 9 for node GSK3B_S9 and MTOR\n", + "looking for paths in the network with length: 10 for node GSK3B_S9 and MTOR\n", + "i_search = 4\n", + "Looking for paths with length: 0 for node GSK3B_S9 and MTOR\n", + "i_search = 4\n", + "Looking for paths with length: 1 for node GSK3B_S9 and MTOR\n", + "i_search = 4\n", + "Looking for paths with length: 2 for node GSK3B_S9 and MTOR\n", + "i_search = 4\n", + "Looking for paths with length: 3 for node GSK3B_S9 and MTOR\n", + "i_search = 4\n", + "Looking for paths with length: 4 for node GSK3B_S9 and MTOR\n", + "looking for paths in the network with length: 0 for node GSK3B_S9 and JUN\n", + "looking for paths in the network with length: 1 for node GSK3B_S9 and JUN\n", + "looking for paths in the network with length: 2 for node GSK3B_S9 and JUN\n", + "looking for paths in the network with length: 3 for node GSK3B_S9 and JUN\n", + "looking for paths in the network with length: 4 for node GSK3B_S9 and JUN\n", + "looking for paths in the network with length: 5 for node GSK3B_S9 and JUN\n", + "looking for paths in the network with length: 6 for node GSK3B_S9 and JUN\n", + "looking for paths in the network with length: 7 for node GSK3B_S9 and JUN\n", + "looking for paths in the network with length: 8 for node GSK3B_S9 and JUN\n", + "looking for paths in the network with length: 9 for node GSK3B_S9 and JUN\n", + "looking for paths in the network with length: 10 for node GSK3B_S9 and JUN\n", + "i_search = 4\n", + "Looking for paths with length: 0 for node GSK3B_S9 and JUN\n", + "i_search = 4\n", + "Looking for paths with length: 1 for node GSK3B_S9 and JUN\n", + "i_search = 4\n", + "Looking for paths with length: 2 for node GSK3B_S9 and JUN\n", + "i_search = 4\n", + "Looking for paths with length: 3 for node GSK3B_S9 and JUN\n", + "i_search = 4\n", + "Looking for paths with length: 4 for node GSK3B_S9 and JUN\n", + "looking for paths in the network with length: 0 for node GSK3B_S9 and EGFR\n", + "looking for paths in the network with length: 1 for node GSK3B_S9 and EGFR\n", + "looking for paths in the network with length: 2 for node GSK3B_S9 and EGFR\n", + "looking for paths in the network with length: 3 for node GSK3B_S9 and EGFR\n", + "looking for paths in the network with length: 4 for node GSK3B_S9 and EGFR\n", + "looking for paths in the network with length: 5 for node GSK3B_S9 and EGFR\n", + "looking for paths in the network with length: 6 for node GSK3B_S9 and EGFR\n", + "looking for paths in the network with length: 7 for node GSK3B_S9 and EGFR\n", + "looking for paths in the network with length: 8 for node GSK3B_S9 and EGFR\n", + "looking for paths in the network with length: 9 for node GSK3B_S9 and EGFR\n", + "looking for paths in the network with length: 10 for node GSK3B_S9 and EGFR\n", + "i_search = 4\n", + "Looking for paths with length: 0 for node GSK3B_S9 and EGFR\n", + "i_search = 4\n", + "Looking for paths with length: 1 for node GSK3B_S9 and EGFR\n", + "i_search = 4\n", + "Looking for paths with length: 2 for node GSK3B_S9 and EGFR\n", + "i_search = 4\n", + "Looking for paths with length: 3 for node GSK3B_S9 and EGFR\n", + "i_search = 4\n", + "Looking for paths with length: 4 for node GSK3B_S9 and EGFR\n", + "looking for paths in the network with length: 0 for node GSK3B_S9 and MAPK3\n", + "looking for paths in the network with length: 1 for node GSK3B_S9 and MAPK3\n", + "looking for paths in the network with length: 2 for node GSK3B_S9 and MAPK3\n", + "looking for paths in the network with length: 3 for node GSK3B_S9 and MAPK3\n", + "looking for paths in the network with length: 4 for node GSK3B_S9 and MAPK3\n", + "looking for paths in the network with length: 5 for node GSK3B_S9 and MAPK3\n", + "looking for paths in the network with length: 6 for node GSK3B_S9 and MAPK3\n", + "looking for paths in the network with length: 7 for node GSK3B_S9 and MAPK3\n", + "looking for paths in the network with length: 8 for node GSK3B_S9 and MAPK3\n", + "looking for paths in the network with length: 9 for node GSK3B_S9 and MAPK3\n", + "looking for paths in the network with length: 10 for node GSK3B_S9 and MAPK3\n", + "i_search = 4\n", + "Looking for paths with length: 0 for node GSK3B_S9 and MAPK3\n", + "i_search = 4\n", + "Looking for paths with length: 1 for node GSK3B_S9 and MAPK3\n", + "i_search = 4\n", + "Looking for paths with length: 2 for node GSK3B_S9 and MAPK3\n", + "i_search = 4\n", + "Looking for paths with length: 3 for node GSK3B_S9 and MAPK3\n", + "i_search = 4\n", + "Looking for paths with length: 4 for node GSK3B_S9 and MAPK3\n", + "looking for paths in the network with length: 0 for node GSK3B_S9 and PTPN11\n", + "looking for paths in the network with length: 1 for node GSK3B_S9 and PTPN11\n", + "looking for paths in the network with length: 2 for node GSK3B_S9 and PTPN11\n", + "looking for paths in the network with length: 3 for node GSK3B_S9 and PTPN11\n", + "looking for paths in the network with length: 4 for node GSK3B_S9 and PTPN11\n", + "looking for paths in the network with length: 5 for node GSK3B_S9 and PTPN11\n", + "looking for paths in the network with length: 6 for node GSK3B_S9 and PTPN11\n", + "looking for paths in the network with length: 7 for node GSK3B_S9 and PTPN11\n", + "looking for paths in the network with length: 8 for node GSK3B_S9 and PTPN11\n", + "looking for paths in the network with length: 9 for node GSK3B_S9 and PTPN11\n", + "looking for paths in the network with length: 10 for node GSK3B_S9 and PTPN11\n", + "i_search = 4\n", + "Looking for paths with length: 0 for node GSK3B_S9 and PTPN11\n", + "i_search = 4\n", + "Looking for paths with length: 1 for node GSK3B_S9 and PTPN11\n", + "i_search = 4\n", + "Looking for paths with length: 2 for node GSK3B_S9 and PTPN11\n", + "i_search = 4\n", + "Looking for paths with length: 3 for node GSK3B_S9 and PTPN11\n", + "i_search = 4\n", + "Looking for paths with length: 4 for node GSK3B_S9 and PTPN11\n", + "looking for paths in the network with length: 0 for node GSK3B_S9 and STAT3\n", + "looking for paths in the network with length: 1 for node GSK3B_S9 and STAT3\n", + "looking for paths in the network with length: 2 for node GSK3B_S9 and STAT3\n", + "looking for paths in the network with length: 3 for node GSK3B_S9 and STAT3\n", + "looking for paths in the network with length: 4 for node GSK3B_S9 and STAT3\n", + "looking for paths in the network with length: 5 for node GSK3B_S9 and STAT3\n", + "looking for paths in the network with length: 6 for node GSK3B_S9 and STAT3\n", + "looking for paths in the network with length: 7 for node GSK3B_S9 and STAT3\n", + "looking for paths in the network with length: 8 for node GSK3B_S9 and STAT3\n", + "looking for paths in the network with length: 9 for node GSK3B_S9 and STAT3\n", + "looking for paths in the network with length: 10 for node GSK3B_S9 and STAT3\n", + "i_search = 4\n", + "Looking for paths with length: 0 for node GSK3B_S9 and STAT3\n", + "i_search = 4\n", + "Looking for paths with length: 1 for node GSK3B_S9 and STAT3\n", + "i_search = 4\n", + "Looking for paths with length: 2 for node GSK3B_S9 and STAT3\n", + "i_search = 4\n", + "Looking for paths with length: 3 for node GSK3B_S9 and STAT3\n", + "i_search = 4\n", + "Looking for paths with length: 4 for node GSK3B_S9 and STAT3\n", + "looking for paths in the network with length: 0 for node GSK3B_S9 and CHEK2\n", + "looking for paths in the network with length: 1 for node GSK3B_S9 and CHEK2\n", + "looking for paths in the network with length: 2 for node GSK3B_S9 and CHEK2\n", + "looking for paths in the network with length: 3 for node GSK3B_S9 and CHEK2\n", + "looking for paths in the network with length: 4 for node GSK3B_S9 and CHEK2\n", + "looking for paths in the network with length: 5 for node GSK3B_S9 and CHEK2\n", + "looking for paths in the network with length: 6 for node GSK3B_S9 and CHEK2\n", + "looking for paths in the network with length: 7 for node GSK3B_S9 and CHEK2\n", + "looking for paths in the network with length: 8 for node GSK3B_S9 and CHEK2\n", + "looking for paths in the network with length: 9 for node GSK3B_S9 and CHEK2\n", + "looking for paths in the network with length: 10 for node GSK3B_S9 and CHEK2\n", + "i_search = 4\n", + "Looking for paths with length: 0 for node GSK3B_S9 and CHEK2\n", + "i_search = 4\n", + "Looking for paths with length: 1 for node GSK3B_S9 and CHEK2\n", + "i_search = 4\n", + "Looking for paths with length: 2 for node GSK3B_S9 and CHEK2\n", + "i_search = 4\n", + "Looking for paths with length: 3 for node GSK3B_S9 and CHEK2\n", + "i_search = 4\n", + "Looking for paths with length: 4 for node GSK3B_S9 and CHEK2\n", + "looking for paths in the network with length: 0 for node GSK3B_S9 and RELA\n", + "looking for paths in the network with length: 1 for node GSK3B_S9 and RELA\n", + "looking for paths in the network with length: 2 for node GSK3B_S9 and RELA\n", + "looking for paths in the network with length: 3 for node GSK3B_S9 and RELA\n", + "looking for paths in the network with length: 4 for node GSK3B_S9 and RELA\n", + "looking for paths in the network with length: 5 for node GSK3B_S9 and RELA\n", + "looking for paths in the network with length: 6 for node GSK3B_S9 and RELA\n", + "looking for paths in the network with length: 7 for node GSK3B_S9 and RELA\n", + "looking for paths in the network with length: 8 for node GSK3B_S9 and RELA\n", + "looking for paths in the network with length: 9 for node GSK3B_S9 and RELA\n", + "looking for paths in the network with length: 10 for node GSK3B_S9 and RELA\n", + "i_search = 4\n", + "Looking for paths with length: 0 for node GSK3B_S9 and RELA\n", + "i_search = 4\n", + "Looking for paths with length: 1 for node GSK3B_S9 and RELA\n", + "i_search = 4\n", + "Looking for paths with length: 2 for node GSK3B_S9 and RELA\n", + "i_search = 4\n", + "Looking for paths with length: 3 for node GSK3B_S9 and RELA\n", + "i_search = 4\n", + "Looking for paths with length: 4 for node GSK3B_S9 and RELA\n", + "looking for paths in the network with length: 0 for node GSK3B_S9 and MARCKS\n", + "looking for paths in the network with length: 1 for node GSK3B_S9 and MARCKS\n", + "looking for paths in the network with length: 2 for node GSK3B_S9 and MARCKS\n", + "looking for paths in the network with length: 3 for node GSK3B_S9 and MARCKS\n", + "looking for paths in the network with length: 4 for node GSK3B_S9 and MARCKS\n", + "looking for paths in the network with length: 5 for node GSK3B_S9 and MARCKS\n", + "looking for paths in the network with length: 6 for node GSK3B_S9 and MARCKS\n", + "looking for paths in the network with length: 7 for node GSK3B_S9 and MARCKS\n", + "looking for paths in the network with length: 8 for node GSK3B_S9 and MARCKS\n", + "looking for paths in the network with length: 9 for node GSK3B_S9 and MARCKS\n", + "looking for paths in the network with length: 10 for node GSK3B_S9 and MARCKS\n", + "i_search = 4\n", + "Looking for paths with length: 0 for node GSK3B_S9 and MARCKS\n", + "i_search = 4\n", + "Looking for paths with length: 1 for node GSK3B_S9 and MARCKS\n", + "i_search = 4\n", + "Looking for paths with length: 2 for node GSK3B_S9 and MARCKS\n", + "i_search = 4\n", + "Looking for paths with length: 3 for node GSK3B_S9 and MARCKS\n", + "i_search = 4\n", + "Looking for paths with length: 4 for node GSK3B_S9 and MARCKS\n", + "looking for paths in the network with length: 0 for node GSK3B_S21 and AKT1_S473\n", + "looking for paths in the network with length: 1 for node GSK3B_S21 and AKT1_S473\n", + "looking for paths in the network with length: 2 for node GSK3B_S21 and AKT1_S473\n", + "looking for paths in the network with length: 3 for node GSK3B_S21 and AKT1_S473\n", + "looking for paths in the network with length: 4 for node GSK3B_S21 and AKT1_S473\n", + "looking for paths in the network with length: 5 for node GSK3B_S21 and AKT1_S473\n", + "looking for paths in the network with length: 6 for node GSK3B_S21 and AKT1_S473\n", + "looking for paths in the network with length: 7 for node GSK3B_S21 and AKT1_S473\n", + "looking for paths in the network with length: 8 for node GSK3B_S21 and AKT1_S473\n", + "looking for paths in the network with length: 9 for node GSK3B_S21 and AKT1_S473\n", + "looking for paths in the network with length: 10 for node GSK3B_S21 and AKT1_S473\n", + "i_search = 4\n", + "Looking for paths with length: 0 for node GSK3B_S21 and AKT1_S473\n", + "i_search = 4\n", + "Looking for paths with length: 1 for node GSK3B_S21 and AKT1_S473\n", + "i_search = 4\n", + "Looking for paths with length: 2 for node GSK3B_S21 and AKT1_S473\n", + "i_search = 4\n", + "Looking for paths with length: 3 for node GSK3B_S21 and AKT1_S473\n", + "i_search = 4\n", + "Looking for paths with length: 4 for node GSK3B_S21 and AKT1_S473\n", + "looking for paths in the network with length: 0 for node GSK3B_S21 and HSPB1_S78\n", + "looking for paths in the network with length: 1 for node GSK3B_S21 and HSPB1_S78\n", + "looking for paths in the network with length: 2 for node GSK3B_S21 and HSPB1_S78\n", + "looking for paths in the network with length: 3 for node GSK3B_S21 and HSPB1_S78\n", + "looking for paths in the network with length: 4 for node GSK3B_S21 and HSPB1_S78\n", + "looking for paths in the network with length: 5 for node GSK3B_S21 and HSPB1_S78\n", + "looking for paths in the network with length: 6 for node GSK3B_S21 and HSPB1_S78\n", + "looking for paths in the network with length: 7 for node GSK3B_S21 and HSPB1_S78\n", + "looking for paths in the network with length: 8 for node GSK3B_S21 and HSPB1_S78\n", + "looking for paths in the network with length: 9 for node GSK3B_S21 and HSPB1_S78\n", + "looking for paths in the network with length: 10 for node GSK3B_S21 and HSPB1_S78\n", + "i_search = 4\n", + "Looking for paths with length: 0 for node GSK3B_S21 and HSPB1_S78\n", + "i_search = 4\n", + "Looking for paths with length: 1 for node GSK3B_S21 and HSPB1_S78\n", + "i_search = 4\n", + "Looking for paths with length: 2 for node GSK3B_S21 and HSPB1_S78\n", + "i_search = 4\n", + "Looking for paths with length: 3 for node GSK3B_S21 and HSPB1_S78\n", + "i_search = 4\n", + "Looking for paths with length: 4 for node GSK3B_S21 and HSPB1_S78\n", + "looking for paths in the network with length: 0 for node GSK3B_S21 and HSPB1_S82\n", + "looking for paths in the network with length: 1 for node GSK3B_S21 and HSPB1_S82\n", + "looking for paths in the network with length: 2 for node GSK3B_S21 and HSPB1_S82\n", + "looking for paths in the network with length: 3 for node GSK3B_S21 and HSPB1_S82\n", + "looking for paths in the network with length: 4 for node GSK3B_S21 and HSPB1_S82\n", + "looking for paths in the network with length: 5 for node GSK3B_S21 and HSPB1_S82\n", + "looking for paths in the network with length: 6 for node GSK3B_S21 and HSPB1_S82\n", + "looking for paths in the network with length: 7 for node GSK3B_S21 and HSPB1_S82\n", + "looking for paths in the network with length: 8 for node GSK3B_S21 and HSPB1_S82\n", + "looking for paths in the network with length: 9 for node GSK3B_S21 and HSPB1_S82\n", + "looking for paths in the network with length: 10 for node GSK3B_S21 and HSPB1_S82\n", + "i_search = 4\n", + "Looking for paths with length: 0 for node GSK3B_S21 and HSPB1_S82\n", + "i_search = 4\n", + "Looking for paths with length: 1 for node GSK3B_S21 and HSPB1_S82\n", + "i_search = 4\n", + "Looking for paths with length: 2 for node GSK3B_S21 and HSPB1_S82\n", + "i_search = 4\n", + "Looking for paths with length: 3 for node GSK3B_S21 and HSPB1_S82\n", + "i_search = 4\n", + "Looking for paths with length: 4 for node GSK3B_S21 and HSPB1_S82\n", + "looking for paths in the network with length: 0 for node GSK3B_S21 and MAPK14_T180\n", + "looking for paths in the network with length: 1 for node GSK3B_S21 and MAPK14_T180\n", + "looking for paths in the network with length: 2 for node GSK3B_S21 and MAPK14_T180\n", + "looking for paths in the network with length: 3 for node GSK3B_S21 and MAPK14_T180\n", + "looking for paths in the network with length: 4 for node GSK3B_S21 and MAPK14_T180\n", + "looking for paths in the network with length: 5 for node GSK3B_S21 and MAPK14_T180\n", + "looking for paths in the network with length: 6 for node GSK3B_S21 and MAPK14_T180\n", + "looking for paths in the network with length: 7 for node GSK3B_S21 and MAPK14_T180\n", + "looking for paths in the network with length: 8 for node GSK3B_S21 and MAPK14_T180\n", + "looking for paths in the network with length: 9 for node GSK3B_S21 and MAPK14_T180\n", + "looking for paths in the network with length: 10 for node GSK3B_S21 and MAPK14_T180\n", + "i_search = 4\n", + "Looking for paths with length: 0 for node GSK3B_S21 and MAPK14_T180\n", + "i_search = 4\n", + "Looking for paths with length: 1 for node GSK3B_S21 and MAPK14_T180\n", + "i_search = 4\n", + "Looking for paths with length: 2 for node GSK3B_S21 and MAPK14_T180\n", + "i_search = 4\n", + "Looking for paths with length: 3 for node GSK3B_S21 and MAPK14_T180\n", + "i_search = 4\n", + "Looking for paths with length: 4 for node GSK3B_S21 and MAPK14_T180\n", + "looking for paths in the network with length: 0 for node GSK3B_S21 and MAPK14_Y182\n", + "looking for paths in the network with length: 1 for node GSK3B_S21 and MAPK14_Y182\n", + "looking for paths in the network with length: 2 for node GSK3B_S21 and MAPK14_Y182\n", + "looking for paths in the network with length: 3 for node GSK3B_S21 and MAPK14_Y182\n", + "looking for paths in the network with length: 4 for node GSK3B_S21 and MAPK14_Y182\n", + "looking for paths in the network with length: 5 for node GSK3B_S21 and MAPK14_Y182\n", + "looking for paths in the network with length: 6 for node GSK3B_S21 and MAPK14_Y182\n", + "looking for paths in the network with length: 7 for node GSK3B_S21 and MAPK14_Y182\n", + "looking for paths in the network with length: 8 for node GSK3B_S21 and MAPK14_Y182\n", + "looking for paths in the network with length: 9 for node GSK3B_S21 and MAPK14_Y182\n", + "looking for paths in the network with length: 10 for node GSK3B_S21 and MAPK14_Y182\n", + "i_search = 4\n", + "Looking for paths with length: 0 for node GSK3B_S21 and MAPK14_Y182\n", + "i_search = 4\n", + "Looking for paths with length: 1 for node GSK3B_S21 and MAPK14_Y182\n", + "i_search = 4\n", + "Looking for paths with length: 2 for node GSK3B_S21 and MAPK14_Y182\n", + "i_search = 4\n", + "Looking for paths with length: 3 for node GSK3B_S21 and MAPK14_Y182\n", + "i_search = 4\n", + "Looking for paths with length: 4 for node GSK3B_S21 and MAPK14_Y182\n", + "looking for paths in the network with length: 0 for node GSK3B_S21 and MAP2K1_S218\n", + "looking for paths in the network with length: 1 for node GSK3B_S21 and MAP2K1_S218\n", + "looking for paths in the network with length: 2 for node GSK3B_S21 and MAP2K1_S218\n", + "looking for paths in the network with length: 3 for node GSK3B_S21 and MAP2K1_S218\n", + "looking for paths in the network with length: 4 for node GSK3B_S21 and MAP2K1_S218\n", + "looking for paths in the network with length: 5 for node GSK3B_S21 and MAP2K1_S218\n", + "looking for paths in the network with length: 6 for node GSK3B_S21 and MAP2K1_S218\n", + "looking for paths in the network with length: 7 for node GSK3B_S21 and MAP2K1_S218\n", + "looking for paths in the network with length: 8 for node GSK3B_S21 and MAP2K1_S218\n", + "looking for paths in the network with length: 9 for node GSK3B_S21 and MAP2K1_S218\n", + "looking for paths in the network with length: 10 for node GSK3B_S21 and MAP2K1_S218\n", + "i_search = 4\n", + "Looking for paths with length: 0 for node GSK3B_S21 and MAP2K1_S218\n", + "i_search = 4\n", + "Looking for paths with length: 1 for node GSK3B_S21 and MAP2K1_S218\n", + "i_search = 4\n", + "Looking for paths with length: 2 for node GSK3B_S21 and MAP2K1_S218\n", + "i_search = 4\n", + "Looking for paths with length: 3 for node GSK3B_S21 and MAP2K1_S218\n", + "i_search = 4\n", + "Looking for paths with length: 4 for node GSK3B_S21 and MAP2K1_S218\n", + "looking for paths in the network with length: 0 for node GSK3B_S21 and MAP2K1_S222\n", + "looking for paths in the network with length: 1 for node GSK3B_S21 and MAP2K1_S222\n", + "looking for paths in the network with length: 2 for node GSK3B_S21 and MAP2K1_S222\n", + "looking for paths in the network with length: 3 for node GSK3B_S21 and MAP2K1_S222\n", + "looking for paths in the network with length: 4 for node GSK3B_S21 and MAP2K1_S222\n", + "looking for paths in the network with length: 5 for node GSK3B_S21 and MAP2K1_S222\n", + "looking for paths in the network with length: 6 for node GSK3B_S21 and MAP2K1_S222\n", + "looking for paths in the network with length: 7 for node GSK3B_S21 and MAP2K1_S222\n", + "looking for paths in the network with length: 8 for node GSK3B_S21 and MAP2K1_S222\n", + "looking for paths in the network with length: 9 for node GSK3B_S21 and MAP2K1_S222\n", + "looking for paths in the network with length: 10 for node GSK3B_S21 and MAP2K1_S222\n", + "i_search = 4\n", + "Looking for paths with length: 0 for node GSK3B_S21 and MAP2K1_S222\n", + "i_search = 4\n", + "Looking for paths with length: 1 for node GSK3B_S21 and MAP2K1_S222\n", + "i_search = 4\n", + "Looking for paths with length: 2 for node GSK3B_S21 and MAP2K1_S222\n", + "i_search = 4\n", + "Looking for paths with length: 3 for node GSK3B_S21 and MAP2K1_S222\n", + "i_search = 4\n", + "Looking for paths with length: 4 for node GSK3B_S21 and MAP2K1_S222\n", + "looking for paths in the network with length: 0 for node GSK3B_S21 and RPS6KA1_S380\n", + "looking for paths in the network with length: 1 for node GSK3B_S21 and RPS6KA1_S380\n", + "looking for paths in the network with length: 2 for node GSK3B_S21 and RPS6KA1_S380\n", + "looking for paths in the network with length: 3 for node GSK3B_S21 and RPS6KA1_S380\n", + "looking for paths in the network with length: 4 for node GSK3B_S21 and RPS6KA1_S380\n", + "looking for paths in the network with length: 5 for node GSK3B_S21 and RPS6KA1_S380\n", + "looking for paths in the network with length: 6 for node GSK3B_S21 and RPS6KA1_S380\n", + "looking for paths in the network with length: 7 for node GSK3B_S21 and RPS6KA1_S380\n", + "looking for paths in the network with length: 8 for node GSK3B_S21 and RPS6KA1_S380\n", + "looking for paths in the network with length: 9 for node GSK3B_S21 and RPS6KA1_S380\n", + "looking for paths in the network with length: 10 for node GSK3B_S21 and RPS6KA1_S380\n", + "i_search = 4\n", + "Looking for paths with length: 0 for node GSK3B_S21 and RPS6KA1_S380\n", + "i_search = 4\n", + "Looking for paths with length: 1 for node GSK3B_S21 and RPS6KA1_S380\n", + "i_search = 4\n", + "Looking for paths with length: 2 for node GSK3B_S21 and RPS6KA1_S380\n", + "i_search = 4\n", + "Looking for paths with length: 3 for node GSK3B_S21 and RPS6KA1_S380\n", + "i_search = 4\n", + "Looking for paths with length: 4 for node GSK3B_S21 and RPS6KA1_S380\n", + "looking for paths in the network with length: 0 for node GSK3B_S21 and CREB1_S133\n", + "looking for paths in the network with length: 1 for node GSK3B_S21 and CREB1_S133\n", + "looking for paths in the network with length: 2 for node GSK3B_S21 and CREB1_S133\n", + "looking for paths in the network with length: 3 for node GSK3B_S21 and CREB1_S133\n", + "looking for paths in the network with length: 4 for node GSK3B_S21 and CREB1_S133\n", + "looking for paths in the network with length: 5 for node GSK3B_S21 and CREB1_S133\n", + "looking for paths in the network with length: 6 for node GSK3B_S21 and CREB1_S133\n", + "looking for paths in the network with length: 7 for node GSK3B_S21 and CREB1_S133\n", + "looking for paths in the network with length: 8 for node GSK3B_S21 and CREB1_S133\n", + "looking for paths in the network with length: 9 for node GSK3B_S21 and CREB1_S133\n", + "looking for paths in the network with length: 10 for node GSK3B_S21 and CREB1_S133\n", + "i_search = 4\n", + "Looking for paths with length: 0 for node GSK3B_S21 and CREB1_S133\n", + "i_search = 4\n", + "Looking for paths with length: 1 for node GSK3B_S21 and CREB1_S133\n", + "i_search = 4\n", + "Looking for paths with length: 2 for node GSK3B_S21 and CREB1_S133\n", + "i_search = 4\n", + "Looking for paths with length: 3 for node GSK3B_S21 and CREB1_S133\n", + "i_search = 4\n", + "Looking for paths with length: 4 for node GSK3B_S21 and CREB1_S133\n", + "looking for paths in the network with length: 0 for node GSK3B_S21 and NFKBIA_S32\n", + "looking for paths in the network with length: 1 for node GSK3B_S21 and NFKBIA_S32\n", + "looking for paths in the network with length: 2 for node GSK3B_S21 and NFKBIA_S32\n", + "looking for paths in the network with length: 3 for node GSK3B_S21 and NFKBIA_S32\n", + "looking for paths in the network with length: 4 for node GSK3B_S21 and NFKBIA_S32\n", + "looking for paths in the network with length: 5 for node GSK3B_S21 and NFKBIA_S32\n", + "looking for paths in the network with length: 6 for node GSK3B_S21 and NFKBIA_S32\n", + "looking for paths in the network with length: 7 for node GSK3B_S21 and NFKBIA_S32\n", + "looking for paths in the network with length: 8 for node GSK3B_S21 and NFKBIA_S32\n", + "looking for paths in the network with length: 9 for node GSK3B_S21 and NFKBIA_S32\n", + "looking for paths in the network with length: 10 for node GSK3B_S21 and NFKBIA_S32\n", + "i_search = 4\n", + "Looking for paths with length: 0 for node GSK3B_S21 and NFKBIA_S32\n", + "i_search = 4\n", + "Looking for paths with length: 1 for node GSK3B_S21 and NFKBIA_S32\n", + "i_search = 4\n", + "Looking for paths with length: 2 for node GSK3B_S21 and NFKBIA_S32\n", + "i_search = 4\n", + "Looking for paths with length: 3 for node GSK3B_S21 and NFKBIA_S32\n", + "i_search = 4\n", + "Looking for paths with length: 4 for node GSK3B_S21 and NFKBIA_S32\n", + "looking for paths in the network with length: 0 for node GSK3B_S21 and NFKBIA_S36\n", + "looking for paths in the network with length: 1 for node GSK3B_S21 and NFKBIA_S36\n", + "looking for paths in the network with length: 2 for node GSK3B_S21 and NFKBIA_S36\n", + "looking for paths in the network with length: 3 for node GSK3B_S21 and NFKBIA_S36\n", + "looking for paths in the network with length: 4 for node GSK3B_S21 and NFKBIA_S36\n", + "looking for paths in the network with length: 5 for node GSK3B_S21 and NFKBIA_S36\n", + "looking for paths in the network with length: 6 for node GSK3B_S21 and NFKBIA_S36\n", + "looking for paths in the network with length: 7 for node GSK3B_S21 and NFKBIA_S36\n", + "looking for paths in the network with length: 8 for node GSK3B_S21 and NFKBIA_S36\n", + "looking for paths in the network with length: 9 for node GSK3B_S21 and NFKBIA_S36\n", + "looking for paths in the network with length: 10 for node GSK3B_S21 and NFKBIA_S36\n", + "i_search = 4\n", + "Looking for paths with length: 0 for node GSK3B_S21 and NFKBIA_S36\n", + "i_search = 4\n", + "Looking for paths with length: 1 for node GSK3B_S21 and NFKBIA_S36\n", + "i_search = 4\n", + "Looking for paths with length: 2 for node GSK3B_S21 and NFKBIA_S36\n", + "i_search = 4\n", + "Looking for paths with length: 3 for node GSK3B_S21 and NFKBIA_S36\n", + "i_search = 4\n", + "Looking for paths with length: 4 for node GSK3B_S21 and NFKBIA_S36\n", + "looking for paths in the network with length: 0 for node GSK3B_S21 and MTOR_S2448\n", + "looking for paths in the network with length: 1 for node GSK3B_S21 and MTOR_S2448\n", + "looking for paths in the network with length: 2 for node GSK3B_S21 and MTOR_S2448\n", + "looking for paths in the network with length: 3 for node GSK3B_S21 and MTOR_S2448\n", + "looking for paths in the network with length: 4 for node GSK3B_S21 and MTOR_S2448\n", + "looking for paths in the network with length: 5 for node GSK3B_S21 and MTOR_S2448\n", + "looking for paths in the network with length: 6 for node GSK3B_S21 and MTOR_S2448\n", + "looking for paths in the network with length: 7 for node GSK3B_S21 and MTOR_S2448\n", + "looking for paths in the network with length: 8 for node GSK3B_S21 and MTOR_S2448\n", + "looking for paths in the network with length: 9 for node GSK3B_S21 and MTOR_S2448\n", + "looking for paths in the network with length: 10 for node GSK3B_S21 and MTOR_S2448\n", + "i_search = 4\n", + "Looking for paths with length: 0 for node GSK3B_S21 and MTOR_S2448\n", + "i_search = 4\n", + "Looking for paths with length: 1 for node GSK3B_S21 and MTOR_S2448\n", + "i_search = 4\n", + "Looking for paths with length: 2 for node GSK3B_S21 and MTOR_S2448\n", + "i_search = 4\n", + "Looking for paths with length: 3 for node GSK3B_S21 and MTOR_S2448\n", + "i_search = 4\n", + "Looking for paths with length: 4 for node GSK3B_S21 and MTOR_S2448\n", + "looking for paths in the network with length: 0 for node GSK3B_S21 and JUN_S63\n", + "looking for paths in the network with length: 1 for node GSK3B_S21 and JUN_S63\n", + "looking for paths in the network with length: 2 for node GSK3B_S21 and JUN_S63\n", + "looking for paths in the network with length: 3 for node GSK3B_S21 and JUN_S63\n", + "looking for paths in the network with length: 4 for node GSK3B_S21 and JUN_S63\n", + "looking for paths in the network with length: 5 for node GSK3B_S21 and JUN_S63\n", + "looking for paths in the network with length: 6 for node GSK3B_S21 and JUN_S63\n", + "looking for paths in the network with length: 7 for node GSK3B_S21 and JUN_S63\n", + "looking for paths in the network with length: 8 for node GSK3B_S21 and JUN_S63\n", + "looking for paths in the network with length: 9 for node GSK3B_S21 and JUN_S63\n", + "looking for paths in the network with length: 10 for node GSK3B_S21 and JUN_S63\n", + "i_search = 4\n", + "Looking for paths with length: 0 for node GSK3B_S21 and JUN_S63\n", + "i_search = 4\n", + "Looking for paths with length: 1 for node GSK3B_S21 and JUN_S63\n", + "i_search = 4\n", + "Looking for paths with length: 2 for node GSK3B_S21 and JUN_S63\n", + "i_search = 4\n", + "Looking for paths with length: 3 for node GSK3B_S21 and JUN_S63\n", + "i_search = 4\n", + "Looking for paths with length: 4 for node GSK3B_S21 and JUN_S63\n", + "looking for paths in the network with length: 0 for node GSK3B_S21 and EGFR_Y1068\n", + "looking for paths in the network with length: 1 for node GSK3B_S21 and EGFR_Y1068\n", + "looking for paths in the network with length: 2 for node GSK3B_S21 and EGFR_Y1068\n", + "looking for paths in the network with length: 3 for node GSK3B_S21 and EGFR_Y1068\n", + "looking for paths in the network with length: 4 for node GSK3B_S21 and EGFR_Y1068\n", + "looking for paths in the network with length: 5 for node GSK3B_S21 and EGFR_Y1068\n", + "looking for paths in the network with length: 6 for node GSK3B_S21 and EGFR_Y1068\n", + "looking for paths in the network with length: 7 for node GSK3B_S21 and EGFR_Y1068\n", + "looking for paths in the network with length: 8 for node GSK3B_S21 and EGFR_Y1068\n", + "looking for paths in the network with length: 9 for node GSK3B_S21 and EGFR_Y1068\n", + "looking for paths in the network with length: 10 for node GSK3B_S21 and EGFR_Y1068\n", + "i_search = 4\n", + "Looking for paths with length: 0 for node GSK3B_S21 and EGFR_Y1068\n", + "i_search = 4\n", + "Looking for paths with length: 1 for node GSK3B_S21 and EGFR_Y1068\n", + "i_search = 4\n", + "Looking for paths with length: 2 for node GSK3B_S21 and EGFR_Y1068\n", + "i_search = 4\n", + "Looking for paths with length: 3 for node GSK3B_S21 and EGFR_Y1068\n", + "i_search = 4\n", + "Looking for paths with length: 4 for node GSK3B_S21 and EGFR_Y1068\n", + "looking for paths in the network with length: 0 for node GSK3B_S21 and MAPK3_T202\n", + "looking for paths in the network with length: 1 for node GSK3B_S21 and MAPK3_T202\n", + "looking for paths in the network with length: 2 for node GSK3B_S21 and MAPK3_T202\n", + "looking for paths in the network with length: 3 for node GSK3B_S21 and MAPK3_T202\n", + "looking for paths in the network with length: 4 for node GSK3B_S21 and MAPK3_T202\n", + "looking for paths in the network with length: 5 for node GSK3B_S21 and MAPK3_T202\n", + "looking for paths in the network with length: 6 for node GSK3B_S21 and MAPK3_T202\n", + "looking for paths in the network with length: 7 for node GSK3B_S21 and MAPK3_T202\n", + "looking for paths in the network with length: 8 for node GSK3B_S21 and MAPK3_T202\n", + "looking for paths in the network with length: 9 for node GSK3B_S21 and MAPK3_T202\n", + "looking for paths in the network with length: 10 for node GSK3B_S21 and MAPK3_T202\n", + "i_search = 4\n", + "Looking for paths with length: 0 for node GSK3B_S21 and MAPK3_T202\n", + "i_search = 4\n", + "Looking for paths with length: 1 for node GSK3B_S21 and MAPK3_T202\n", + "i_search = 4\n", + "Looking for paths with length: 2 for node GSK3B_S21 and MAPK3_T202\n", + "i_search = 4\n", + "Looking for paths with length: 3 for node GSK3B_S21 and MAPK3_T202\n", + "i_search = 4\n", + "Looking for paths with length: 4 for node GSK3B_S21 and MAPK3_T202\n", + "looking for paths in the network with length: 0 for node GSK3B_S21 and MAPK3_Y204\n", + "looking for paths in the network with length: 1 for node GSK3B_S21 and MAPK3_Y204\n", + "looking for paths in the network with length: 2 for node GSK3B_S21 and MAPK3_Y204\n", + "looking for paths in the network with length: 3 for node GSK3B_S21 and MAPK3_Y204\n", + "looking for paths in the network with length: 4 for node GSK3B_S21 and MAPK3_Y204\n", + "looking for paths in the network with length: 5 for node GSK3B_S21 and MAPK3_Y204\n", + "looking for paths in the network with length: 6 for node GSK3B_S21 and MAPK3_Y204\n", + "looking for paths in the network with length: 7 for node GSK3B_S21 and MAPK3_Y204\n", + "looking for paths in the network with length: 8 for node GSK3B_S21 and MAPK3_Y204\n", + "looking for paths in the network with length: 9 for node GSK3B_S21 and MAPK3_Y204\n", + "looking for paths in the network with length: 10 for node GSK3B_S21 and MAPK3_Y204\n", + "i_search = 4\n", + "Looking for paths with length: 0 for node GSK3B_S21 and MAPK3_Y204\n", + "i_search = 4\n", + "Looking for paths with length: 1 for node GSK3B_S21 and MAPK3_Y204\n", + "i_search = 4\n", + "Looking for paths with length: 2 for node GSK3B_S21 and MAPK3_Y204\n", + "i_search = 4\n", + "Looking for paths with length: 3 for node GSK3B_S21 and MAPK3_Y204\n", + "i_search = 4\n", + "Looking for paths with length: 4 for node GSK3B_S21 and MAPK3_Y204\n", + "looking for paths in the network with length: 0 for node GSK3B_S21 and PTPN11_Y542\n", + "looking for paths in the network with length: 1 for node GSK3B_S21 and PTPN11_Y542\n", + "looking for paths in the network with length: 2 for node GSK3B_S21 and PTPN11_Y542\n", + "looking for paths in the network with length: 3 for node GSK3B_S21 and PTPN11_Y542\n", + "looking for paths in the network with length: 4 for node GSK3B_S21 and PTPN11_Y542\n", + "looking for paths in the network with length: 5 for node GSK3B_S21 and PTPN11_Y542\n", + "looking for paths in the network with length: 6 for node GSK3B_S21 and PTPN11_Y542\n", + "looking for paths in the network with length: 7 for node GSK3B_S21 and PTPN11_Y542\n", + "looking for paths in the network with length: 8 for node GSK3B_S21 and PTPN11_Y542\n", + "looking for paths in the network with length: 9 for node GSK3B_S21 and PTPN11_Y542\n", + "looking for paths in the network with length: 10 for node GSK3B_S21 and PTPN11_Y542\n", + "i_search = 4\n", + "Looking for paths with length: 0 for node GSK3B_S21 and PTPN11_Y542\n", + "i_search = 4\n", + "Looking for paths with length: 1 for node GSK3B_S21 and PTPN11_Y542\n", + "i_search = 4\n", + "Looking for paths with length: 2 for node GSK3B_S21 and PTPN11_Y542\n", + "i_search = 4\n", + "Looking for paths with length: 3 for node GSK3B_S21 and PTPN11_Y542\n", + "i_search = 4\n", + "Looking for paths with length: 4 for node GSK3B_S21 and PTPN11_Y542\n", + "looking for paths in the network with length: 0 for node GSK3B_S21 and STAT3_Y705\n", + "looking for paths in the network with length: 1 for node GSK3B_S21 and STAT3_Y705\n", + "looking for paths in the network with length: 2 for node GSK3B_S21 and STAT3_Y705\n", + "looking for paths in the network with length: 3 for node GSK3B_S21 and STAT3_Y705\n", + "looking for paths in the network with length: 4 for node GSK3B_S21 and STAT3_Y705\n", + "looking for paths in the network with length: 5 for node GSK3B_S21 and STAT3_Y705\n", + "looking for paths in the network with length: 6 for node GSK3B_S21 and STAT3_Y705\n", + "looking for paths in the network with length: 7 for node GSK3B_S21 and STAT3_Y705\n", + "looking for paths in the network with length: 8 for node GSK3B_S21 and STAT3_Y705\n", + "looking for paths in the network with length: 9 for node GSK3B_S21 and STAT3_Y705\n", + "looking for paths in the network with length: 10 for node GSK3B_S21 and STAT3_Y705\n", + "i_search = 4\n", + "Looking for paths with length: 0 for node GSK3B_S21 and STAT3_Y705\n", + "i_search = 4\n", + "Looking for paths with length: 1 for node GSK3B_S21 and STAT3_Y705\n", + "i_search = 4\n", + "Looking for paths with length: 2 for node GSK3B_S21 and STAT3_Y705\n", + "i_search = 4\n", + "Looking for paths with length: 3 for node GSK3B_S21 and STAT3_Y705\n", + "i_search = 4\n", + "Looking for paths with length: 4 for node GSK3B_S21 and STAT3_Y705\n", + "looking for paths in the network with length: 0 for node GSK3B_S21 and CHEK2_T68\n", + "looking for paths in the network with length: 1 for node GSK3B_S21 and CHEK2_T68\n", + "looking for paths in the network with length: 2 for node GSK3B_S21 and CHEK2_T68\n", + "looking for paths in the network with length: 3 for node GSK3B_S21 and CHEK2_T68\n", + "looking for paths in the network with length: 4 for node GSK3B_S21 and CHEK2_T68\n", + "looking for paths in the network with length: 5 for node GSK3B_S21 and CHEK2_T68\n", + "looking for paths in the network with length: 6 for node GSK3B_S21 and CHEK2_T68\n", + "looking for paths in the network with length: 7 for node GSK3B_S21 and CHEK2_T68\n", + "looking for paths in the network with length: 8 for node GSK3B_S21 and CHEK2_T68\n", + "looking for paths in the network with length: 9 for node GSK3B_S21 and CHEK2_T68\n", + "looking for paths in the network with length: 10 for node GSK3B_S21 and CHEK2_T68\n", + "i_search = 4\n", + "Looking for paths with length: 0 for node GSK3B_S21 and CHEK2_T68\n", + "i_search = 4\n", + "Looking for paths with length: 1 for node GSK3B_S21 and CHEK2_T68\n", + "i_search = 4\n", + "Looking for paths with length: 2 for node GSK3B_S21 and CHEK2_T68\n", + "i_search = 4\n", + "Looking for paths with length: 3 for node GSK3B_S21 and CHEK2_T68\n", + "i_search = 4\n", + "Looking for paths with length: 4 for node GSK3B_S21 and CHEK2_T68\n", + "looking for paths in the network with length: 0 for node GSK3B_S21 and RELA_S536\n", + "looking for paths in the network with length: 1 for node GSK3B_S21 and RELA_S536\n", + "looking for paths in the network with length: 2 for node GSK3B_S21 and RELA_S536\n", + "looking for paths in the network with length: 3 for node GSK3B_S21 and RELA_S536\n", + "looking for paths in the network with length: 4 for node GSK3B_S21 and RELA_S536\n", + "looking for paths in the network with length: 5 for node GSK3B_S21 and RELA_S536\n", + "looking for paths in the network with length: 6 for node GSK3B_S21 and RELA_S536\n", + "looking for paths in the network with length: 7 for node GSK3B_S21 and RELA_S536\n", + "looking for paths in the network with length: 8 for node GSK3B_S21 and RELA_S536\n", + "looking for paths in the network with length: 9 for node GSK3B_S21 and RELA_S536\n", + "looking for paths in the network with length: 10 for node GSK3B_S21 and RELA_S536\n", + "i_search = 4\n", + "Looking for paths with length: 0 for node GSK3B_S21 and RELA_S536\n", + "i_search = 4\n", + "Looking for paths with length: 1 for node GSK3B_S21 and RELA_S536\n", + "i_search = 4\n", + "Looking for paths with length: 2 for node GSK3B_S21 and RELA_S536\n", + "i_search = 4\n", + "Looking for paths with length: 3 for node GSK3B_S21 and RELA_S536\n", + "i_search = 4\n", + "Looking for paths with length: 4 for node GSK3B_S21 and RELA_S536\n", + "looking for paths in the network with length: 0 for node GSK3B_S21 and MARCKS_S170\n", + "looking for paths in the network with length: 1 for node GSK3B_S21 and MARCKS_S170\n", + "looking for paths in the network with length: 2 for node GSK3B_S21 and MARCKS_S170\n", + "looking for paths in the network with length: 3 for node GSK3B_S21 and MARCKS_S170\n", + "looking for paths in the network with length: 4 for node GSK3B_S21 and MARCKS_S170\n", + "looking for paths in the network with length: 5 for node GSK3B_S21 and MARCKS_S170\n", + "looking for paths in the network with length: 6 for node GSK3B_S21 and MARCKS_S170\n", + "looking for paths in the network with length: 7 for node GSK3B_S21 and MARCKS_S170\n", + "looking for paths in the network with length: 8 for node GSK3B_S21 and MARCKS_S170\n", + "looking for paths in the network with length: 9 for node GSK3B_S21 and MARCKS_S170\n", + "looking for paths in the network with length: 10 for node GSK3B_S21 and MARCKS_S170\n", + "i_search = 4\n", + "Looking for paths with length: 0 for node GSK3B_S21 and MARCKS_S170\n", + "i_search = 4\n", + "Looking for paths with length: 1 for node GSK3B_S21 and MARCKS_S170\n", + "i_search = 4\n", + "Looking for paths with length: 2 for node GSK3B_S21 and MARCKS_S170\n", + "i_search = 4\n", + "Looking for paths with length: 3 for node GSK3B_S21 and MARCKS_S170\n", + "i_search = 4\n", + "Looking for paths with length: 4 for node GSK3B_S21 and MARCKS_S170\n", + "looking for paths in the network with length: 0 for node GSK3B_S21 and SMAD3\n", + "looking for paths in the network with length: 1 for node GSK3B_S21 and SMAD3\n", + "looking for paths in the network with length: 2 for node GSK3B_S21 and SMAD3\n", + "looking for paths in the network with length: 3 for node GSK3B_S21 and SMAD3\n", + "looking for paths in the network with length: 4 for node GSK3B_S21 and SMAD3\n", + "looking for paths in the network with length: 5 for node GSK3B_S21 and SMAD3\n", + "looking for paths in the network with length: 6 for node GSK3B_S21 and SMAD3\n", + "looking for paths in the network with length: 7 for node GSK3B_S21 and SMAD3\n", + "looking for paths in the network with length: 8 for node GSK3B_S21 and SMAD3\n", + "looking for paths in the network with length: 9 for node GSK3B_S21 and SMAD3\n", + "looking for paths in the network with length: 10 for node GSK3B_S21 and SMAD3\n", + "i_search = 4\n", + "Looking for paths with length: 0 for node GSK3B_S21 and SMAD3\n", + "i_search = 4\n", + "Looking for paths with length: 1 for node GSK3B_S21 and SMAD3\n", + "i_search = 4\n", + "Looking for paths with length: 2 for node GSK3B_S21 and SMAD3\n", + "i_search = 4\n", + "Looking for paths with length: 3 for node GSK3B_S21 and SMAD3\n", + "i_search = 4\n", + "Looking for paths with length: 4 for node GSK3B_S21 and SMAD3\n", + "looking for paths in the network with length: 0 for node GSK3B_S21 and TP53\n", + "looking for paths in the network with length: 1 for node GSK3B_S21 and TP53\n", + "looking for paths in the network with length: 2 for node GSK3B_S21 and TP53\n", + "looking for paths in the network with length: 3 for node GSK3B_S21 and TP53\n", + "looking for paths in the network with length: 4 for node GSK3B_S21 and TP53\n", + "looking for paths in the network with length: 5 for node GSK3B_S21 and TP53\n", + "looking for paths in the network with length: 6 for node GSK3B_S21 and TP53\n", + "looking for paths in the network with length: 7 for node GSK3B_S21 and TP53\n", + "looking for paths in the network with length: 8 for node GSK3B_S21 and TP53\n", + "looking for paths in the network with length: 9 for node GSK3B_S21 and TP53\n", + "looking for paths in the network with length: 10 for node GSK3B_S21 and TP53\n", + "i_search = 4\n", + "Looking for paths with length: 0 for node GSK3B_S21 and TP53\n", + "i_search = 4\n", + "Looking for paths with length: 1 for node GSK3B_S21 and TP53\n", + "i_search = 4\n", + "Looking for paths with length: 2 for node GSK3B_S21 and TP53\n", + "i_search = 4\n", + "Looking for paths with length: 3 for node GSK3B_S21 and TP53\n", + "i_search = 4\n", + "Looking for paths with length: 4 for node GSK3B_S21 and TP53\n", + "looking for paths in the network with length: 0 for node GSK3B_S21 and AKT1S1\n", + "looking for paths in the network with length: 1 for node GSK3B_S21 and AKT1S1\n", + "looking for paths in the network with length: 2 for node GSK3B_S21 and AKT1S1\n", + "looking for paths in the network with length: 3 for node GSK3B_S21 and AKT1S1\n", + "looking for paths in the network with length: 4 for node GSK3B_S21 and AKT1S1\n", + "looking for paths in the network with length: 5 for node GSK3B_S21 and AKT1S1\n", + "looking for paths in the network with length: 6 for node GSK3B_S21 and AKT1S1\n", + "looking for paths in the network with length: 7 for node GSK3B_S21 and AKT1S1\n", + "looking for paths in the network with length: 8 for node GSK3B_S21 and AKT1S1\n", + "looking for paths in the network with length: 9 for node GSK3B_S21 and AKT1S1\n", + "looking for paths in the network with length: 10 for node GSK3B_S21 and AKT1S1\n", + "i_search = 4\n", + "Looking for paths with length: 0 for node GSK3B_S21 and AKT1S1\n", + "i_search = 4\n", + "Looking for paths with length: 1 for node GSK3B_S21 and AKT1S1\n", + "i_search = 4\n", + "Looking for paths with length: 2 for node GSK3B_S21 and AKT1S1\n", + "i_search = 4\n", + "Looking for paths with length: 3 for node GSK3B_S21 and AKT1S1\n", + "i_search = 4\n", + "Looking for paths with length: 4 for node GSK3B_S21 and AKT1S1\n", + "looking for paths in the network with length: 0 for node GSK3B_S21 and GSK3B\n", + "looking for paths in the network with length: 1 for node GSK3B_S21 and GSK3B\n", + "looking for paths in the network with length: 2 for node GSK3B_S21 and GSK3B\n", + "looking for paths in the network with length: 3 for node GSK3B_S21 and GSK3B\n", + "looking for paths in the network with length: 4 for node GSK3B_S21 and GSK3B\n", + "looking for paths in the network with length: 5 for node GSK3B_S21 and GSK3B\n", + "looking for paths in the network with length: 6 for node GSK3B_S21 and GSK3B\n", + "looking for paths in the network with length: 7 for node GSK3B_S21 and GSK3B\n", + "looking for paths in the network with length: 8 for node GSK3B_S21 and GSK3B\n", + "looking for paths in the network with length: 9 for node GSK3B_S21 and GSK3B\n", + "looking for paths in the network with length: 10 for node GSK3B_S21 and GSK3B\n", + "i_search = 4\n", + "Looking for paths with length: 0 for node GSK3B_S21 and GSK3B\n", + "i_search = 4\n", + "Looking for paths with length: 1 for node GSK3B_S21 and GSK3B\n", + "i_search = 4\n", + "Looking for paths with length: 2 for node GSK3B_S21 and GSK3B\n", + "i_search = 4\n", + "Looking for paths with length: 3 for node GSK3B_S21 and GSK3B\n", + "i_search = 4\n", + "Looking for paths with length: 4 for node GSK3B_S21 and GSK3B\n", + "looking for paths in the network with length: 0 for node GSK3B_S21 and AKT1\n", + "looking for paths in the network with length: 1 for node GSK3B_S21 and AKT1\n", + "looking for paths in the network with length: 2 for node GSK3B_S21 and AKT1\n", + "looking for paths in the network with length: 3 for node GSK3B_S21 and AKT1\n", + "looking for paths in the network with length: 4 for node GSK3B_S21 and AKT1\n", + "looking for paths in the network with length: 5 for node GSK3B_S21 and AKT1\n", + "looking for paths in the network with length: 6 for node GSK3B_S21 and AKT1\n", + "looking for paths in the network with length: 7 for node GSK3B_S21 and AKT1\n", + "looking for paths in the network with length: 8 for node GSK3B_S21 and AKT1\n", + "looking for paths in the network with length: 9 for node GSK3B_S21 and AKT1\n", + "looking for paths in the network with length: 10 for node GSK3B_S21 and AKT1\n", + "i_search = 4\n", + "Looking for paths with length: 0 for node GSK3B_S21 and AKT1\n", + "i_search = 4\n", + "Looking for paths with length: 1 for node GSK3B_S21 and AKT1\n", + "i_search = 4\n", + "Looking for paths with length: 2 for node GSK3B_S21 and AKT1\n", + "i_search = 4\n", + "Looking for paths with length: 3 for node GSK3B_S21 and AKT1\n", + "i_search = 4\n", + "Looking for paths with length: 4 for node GSK3B_S21 and AKT1\n", + "looking for paths in the network with length: 0 for node GSK3B_S21 and HSPB1\n", + "looking for paths in the network with length: 1 for node GSK3B_S21 and HSPB1\n", + "looking for paths in the network with length: 2 for node GSK3B_S21 and HSPB1\n", + "looking for paths in the network with length: 3 for node GSK3B_S21 and HSPB1\n", + "looking for paths in the network with length: 4 for node GSK3B_S21 and HSPB1\n", + "looking for paths in the network with length: 5 for node GSK3B_S21 and HSPB1\n", + "looking for paths in the network with length: 6 for node GSK3B_S21 and HSPB1\n", + "looking for paths in the network with length: 7 for node GSK3B_S21 and HSPB1\n", + "looking for paths in the network with length: 8 for node GSK3B_S21 and HSPB1\n", + "looking for paths in the network with length: 9 for node GSK3B_S21 and HSPB1\n", + "looking for paths in the network with length: 10 for node GSK3B_S21 and HSPB1\n", + "i_search = 4\n", + "Looking for paths with length: 0 for node GSK3B_S21 and HSPB1\n", + "i_search = 4\n", + "Looking for paths with length: 1 for node GSK3B_S21 and HSPB1\n", + "i_search = 4\n", + "Looking for paths with length: 2 for node GSK3B_S21 and HSPB1\n", + "i_search = 4\n", + "Looking for paths with length: 3 for node GSK3B_S21 and HSPB1\n", + "i_search = 4\n", + "Looking for paths with length: 4 for node GSK3B_S21 and HSPB1\n", + "looking for paths in the network with length: 0 for node GSK3B_S21 and MAPK14\n", + "looking for paths in the network with length: 1 for node GSK3B_S21 and MAPK14\n", + "looking for paths in the network with length: 2 for node GSK3B_S21 and MAPK14\n", + "looking for paths in the network with length: 3 for node GSK3B_S21 and MAPK14\n", + "looking for paths in the network with length: 4 for node GSK3B_S21 and MAPK14\n", + "looking for paths in the network with length: 5 for node GSK3B_S21 and MAPK14\n", + "looking for paths in the network with length: 6 for node GSK3B_S21 and MAPK14\n", + "looking for paths in the network with length: 7 for node GSK3B_S21 and MAPK14\n", + "looking for paths in the network with length: 8 for node GSK3B_S21 and MAPK14\n", + "looking for paths in the network with length: 9 for node GSK3B_S21 and MAPK14\n", + "looking for paths in the network with length: 10 for node GSK3B_S21 and MAPK14\n", + "i_search = 4\n", + "Looking for paths with length: 0 for node GSK3B_S21 and MAPK14\n", + "i_search = 4\n", + "Looking for paths with length: 1 for node GSK3B_S21 and MAPK14\n", + "i_search = 4\n", + "Looking for paths with length: 2 for node GSK3B_S21 and MAPK14\n", + "i_search = 4\n", + "Looking for paths with length: 3 for node GSK3B_S21 and MAPK14\n", + "i_search = 4\n", + "Looking for paths with length: 4 for node GSK3B_S21 and MAPK14\n", + "looking for paths in the network with length: 0 for node GSK3B_S21 and MAP2K1\n", + "looking for paths in the network with length: 1 for node GSK3B_S21 and MAP2K1\n", + "looking for paths in the network with length: 2 for node GSK3B_S21 and MAP2K1\n", + "looking for paths in the network with length: 3 for node GSK3B_S21 and MAP2K1\n", + "looking for paths in the network with length: 4 for node GSK3B_S21 and MAP2K1\n", + "looking for paths in the network with length: 5 for node GSK3B_S21 and MAP2K1\n", + "looking for paths in the network with length: 6 for node GSK3B_S21 and MAP2K1\n", + "looking for paths in the network with length: 7 for node GSK3B_S21 and MAP2K1\n", + "looking for paths in the network with length: 8 for node GSK3B_S21 and MAP2K1\n", + "looking for paths in the network with length: 9 for node GSK3B_S21 and MAP2K1\n", + "looking for paths in the network with length: 10 for node GSK3B_S21 and MAP2K1\n", + "i_search = 4\n", + "Looking for paths with length: 0 for node GSK3B_S21 and MAP2K1\n", + "i_search = 4\n", + "Looking for paths with length: 1 for node GSK3B_S21 and MAP2K1\n", + "i_search = 4\n", + "Looking for paths with length: 2 for node GSK3B_S21 and MAP2K1\n", + "i_search = 4\n", + "Looking for paths with length: 3 for node GSK3B_S21 and MAP2K1\n", + "i_search = 4\n", + "Looking for paths with length: 4 for node GSK3B_S21 and MAP2K1\n", + "looking for paths in the network with length: 0 for node GSK3B_S21 and RPS6KA1\n", + "looking for paths in the network with length: 1 for node GSK3B_S21 and RPS6KA1\n", + "looking for paths in the network with length: 2 for node GSK3B_S21 and RPS6KA1\n", + "looking for paths in the network with length: 3 for node GSK3B_S21 and RPS6KA1\n", + "looking for paths in the network with length: 4 for node GSK3B_S21 and RPS6KA1\n", + "looking for paths in the network with length: 5 for node GSK3B_S21 and RPS6KA1\n", + "looking for paths in the network with length: 6 for node GSK3B_S21 and RPS6KA1\n", + "looking for paths in the network with length: 7 for node GSK3B_S21 and RPS6KA1\n", + "looking for paths in the network with length: 8 for node GSK3B_S21 and RPS6KA1\n", + "looking for paths in the network with length: 9 for node GSK3B_S21 and RPS6KA1\n", + "looking for paths in the network with length: 10 for node GSK3B_S21 and RPS6KA1\n", + "i_search = 4\n", + "Looking for paths with length: 0 for node GSK3B_S21 and RPS6KA1\n", + "i_search = 4\n", + "Looking for paths with length: 1 for node GSK3B_S21 and RPS6KA1\n", + "i_search = 4\n", + "Looking for paths with length: 2 for node GSK3B_S21 and RPS6KA1\n", + "i_search = 4\n", + "Looking for paths with length: 3 for node GSK3B_S21 and RPS6KA1\n", + "i_search = 4\n", + "Looking for paths with length: 4 for node GSK3B_S21 and RPS6KA1\n", + "looking for paths in the network with length: 0 for node GSK3B_S21 and CREB1\n", + "looking for paths in the network with length: 1 for node GSK3B_S21 and CREB1\n", + "looking for paths in the network with length: 2 for node GSK3B_S21 and CREB1\n", + "looking for paths in the network with length: 3 for node GSK3B_S21 and CREB1\n", + "looking for paths in the network with length: 4 for node GSK3B_S21 and CREB1\n", + "looking for paths in the network with length: 5 for node GSK3B_S21 and CREB1\n", + "looking for paths in the network with length: 6 for node GSK3B_S21 and CREB1\n", + "looking for paths in the network with length: 7 for node GSK3B_S21 and CREB1\n", + "looking for paths in the network with length: 8 for node GSK3B_S21 and CREB1\n", + "looking for paths in the network with length: 9 for node GSK3B_S21 and CREB1\n", + "looking for paths in the network with length: 10 for node GSK3B_S21 and CREB1\n", + "i_search = 4\n", + "Looking for paths with length: 0 for node GSK3B_S21 and CREB1\n", + "i_search = 4\n", + "Looking for paths with length: 1 for node GSK3B_S21 and CREB1\n", + "i_search = 4\n", + "Looking for paths with length: 2 for node GSK3B_S21 and CREB1\n", + "i_search = 4\n", + "Looking for paths with length: 3 for node GSK3B_S21 and CREB1\n", + "i_search = 4\n", + "Looking for paths with length: 4 for node GSK3B_S21 and CREB1\n", + "looking for paths in the network with length: 0 for node GSK3B_S21 and NFKBIA\n", + "looking for paths in the network with length: 1 for node GSK3B_S21 and NFKBIA\n", + "looking for paths in the network with length: 2 for node GSK3B_S21 and NFKBIA\n", + "looking for paths in the network with length: 3 for node GSK3B_S21 and NFKBIA\n", + "looking for paths in the network with length: 4 for node GSK3B_S21 and NFKBIA\n", + "looking for paths in the network with length: 5 for node GSK3B_S21 and NFKBIA\n", + "looking for paths in the network with length: 6 for node GSK3B_S21 and NFKBIA\n", + "looking for paths in the network with length: 7 for node GSK3B_S21 and NFKBIA\n", + "looking for paths in the network with length: 8 for node GSK3B_S21 and NFKBIA\n", + "looking for paths in the network with length: 9 for node GSK3B_S21 and NFKBIA\n", + "looking for paths in the network with length: 10 for node GSK3B_S21 and NFKBIA\n", + "i_search = 4\n", + "Looking for paths with length: 0 for node GSK3B_S21 and NFKBIA\n", + "i_search = 4\n", + "Looking for paths with length: 1 for node GSK3B_S21 and NFKBIA\n", + "i_search = 4\n", + "Looking for paths with length: 2 for node GSK3B_S21 and NFKBIA\n", + "i_search = 4\n", + "Looking for paths with length: 3 for node GSK3B_S21 and NFKBIA\n", + "i_search = 4\n", + "Looking for paths with length: 4 for node GSK3B_S21 and NFKBIA\n", + "looking for paths in the network with length: 0 for node GSK3B_S21 and MTOR\n", + "looking for paths in the network with length: 1 for node GSK3B_S21 and MTOR\n", + "looking for paths in the network with length: 2 for node GSK3B_S21 and MTOR\n", + "looking for paths in the network with length: 3 for node GSK3B_S21 and MTOR\n", + "looking for paths in the network with length: 4 for node GSK3B_S21 and MTOR\n", + "looking for paths in the network with length: 5 for node GSK3B_S21 and MTOR\n", + "looking for paths in the network with length: 6 for node GSK3B_S21 and MTOR\n", + "looking for paths in the network with length: 7 for node GSK3B_S21 and MTOR\n", + "looking for paths in the network with length: 8 for node GSK3B_S21 and MTOR\n", + "looking for paths in the network with length: 9 for node GSK3B_S21 and MTOR\n", + "looking for paths in the network with length: 10 for node GSK3B_S21 and MTOR\n", + "i_search = 4\n", + "Looking for paths with length: 0 for node GSK3B_S21 and MTOR\n", + "i_search = 4\n", + "Looking for paths with length: 1 for node GSK3B_S21 and MTOR\n", + "i_search = 4\n", + "Looking for paths with length: 2 for node GSK3B_S21 and MTOR\n", + "i_search = 4\n", + "Looking for paths with length: 3 for node GSK3B_S21 and MTOR\n", + "i_search = 4\n", + "Looking for paths with length: 4 for node GSK3B_S21 and MTOR\n", + "looking for paths in the network with length: 0 for node GSK3B_S21 and JUN\n", + "looking for paths in the network with length: 1 for node GSK3B_S21 and JUN\n", + "looking for paths in the network with length: 2 for node GSK3B_S21 and JUN\n", + "looking for paths in the network with length: 3 for node GSK3B_S21 and JUN\n", + "looking for paths in the network with length: 4 for node GSK3B_S21 and JUN\n", + "looking for paths in the network with length: 5 for node GSK3B_S21 and JUN\n", + "looking for paths in the network with length: 6 for node GSK3B_S21 and JUN\n", + "looking for paths in the network with length: 7 for node GSK3B_S21 and JUN\n", + "looking for paths in the network with length: 8 for node GSK3B_S21 and JUN\n", + "looking for paths in the network with length: 9 for node GSK3B_S21 and JUN\n", + "looking for paths in the network with length: 10 for node GSK3B_S21 and JUN\n", + "i_search = 4\n", + "Looking for paths with length: 0 for node GSK3B_S21 and JUN\n", + "i_search = 4\n", + "Looking for paths with length: 1 for node GSK3B_S21 and JUN\n", + "i_search = 4\n", + "Looking for paths with length: 2 for node GSK3B_S21 and JUN\n", + "i_search = 4\n", + "Looking for paths with length: 3 for node GSK3B_S21 and JUN\n", + "i_search = 4\n", + "Looking for paths with length: 4 for node GSK3B_S21 and JUN\n", + "looking for paths in the network with length: 0 for node GSK3B_S21 and EGFR\n", + "looking for paths in the network with length: 1 for node GSK3B_S21 and EGFR\n", + "looking for paths in the network with length: 2 for node GSK3B_S21 and EGFR\n", + "looking for paths in the network with length: 3 for node GSK3B_S21 and EGFR\n", + "looking for paths in the network with length: 4 for node GSK3B_S21 and EGFR\n", + "looking for paths in the network with length: 5 for node GSK3B_S21 and EGFR\n", + "looking for paths in the network with length: 6 for node GSK3B_S21 and EGFR\n", + "looking for paths in the network with length: 7 for node GSK3B_S21 and EGFR\n", + "looking for paths in the network with length: 8 for node GSK3B_S21 and EGFR\n", + "looking for paths in the network with length: 9 for node GSK3B_S21 and EGFR\n", + "looking for paths in the network with length: 10 for node GSK3B_S21 and EGFR\n", + "i_search = 4\n", + "Looking for paths with length: 0 for node GSK3B_S21 and EGFR\n", + "i_search = 4\n", + "Looking for paths with length: 1 for node GSK3B_S21 and EGFR\n", + "i_search = 4\n", + "Looking for paths with length: 2 for node GSK3B_S21 and EGFR\n", + "i_search = 4\n", + "Looking for paths with length: 3 for node GSK3B_S21 and EGFR\n", + "i_search = 4\n", + "Looking for paths with length: 4 for node GSK3B_S21 and EGFR\n", + "looking for paths in the network with length: 0 for node GSK3B_S21 and MAPK3\n", + "looking for paths in the network with length: 1 for node GSK3B_S21 and MAPK3\n", + "looking for paths in the network with length: 2 for node GSK3B_S21 and MAPK3\n", + "looking for paths in the network with length: 3 for node GSK3B_S21 and MAPK3\n", + "looking for paths in the network with length: 4 for node GSK3B_S21 and MAPK3\n", + "looking for paths in the network with length: 5 for node GSK3B_S21 and MAPK3\n", + "looking for paths in the network with length: 6 for node GSK3B_S21 and MAPK3\n", + "looking for paths in the network with length: 7 for node GSK3B_S21 and MAPK3\n", + "looking for paths in the network with length: 8 for node GSK3B_S21 and MAPK3\n", + "looking for paths in the network with length: 9 for node GSK3B_S21 and MAPK3\n", + "looking for paths in the network with length: 10 for node GSK3B_S21 and MAPK3\n", + "i_search = 4\n", + "Looking for paths with length: 0 for node GSK3B_S21 and MAPK3\n", + "i_search = 4\n", + "Looking for paths with length: 1 for node GSK3B_S21 and MAPK3\n", + "i_search = 4\n", + "Looking for paths with length: 2 for node GSK3B_S21 and MAPK3\n", + "i_search = 4\n", + "Looking for paths with length: 3 for node GSK3B_S21 and MAPK3\n", + "i_search = 4\n", + "Looking for paths with length: 4 for node GSK3B_S21 and MAPK3\n", + "looking for paths in the network with length: 0 for node GSK3B_S21 and PTPN11\n", + "looking for paths in the network with length: 1 for node GSK3B_S21 and PTPN11\n", + "looking for paths in the network with length: 2 for node GSK3B_S21 and PTPN11\n", + "looking for paths in the network with length: 3 for node GSK3B_S21 and PTPN11\n", + "looking for paths in the network with length: 4 for node GSK3B_S21 and PTPN11\n", + "looking for paths in the network with length: 5 for node GSK3B_S21 and PTPN11\n", + "looking for paths in the network with length: 6 for node GSK3B_S21 and PTPN11\n", + "looking for paths in the network with length: 7 for node GSK3B_S21 and PTPN11\n", + "looking for paths in the network with length: 8 for node GSK3B_S21 and PTPN11\n", + "looking for paths in the network with length: 9 for node GSK3B_S21 and PTPN11\n", + "looking for paths in the network with length: 10 for node GSK3B_S21 and PTPN11\n", + "i_search = 4\n", + "Looking for paths with length: 0 for node GSK3B_S21 and PTPN11\n", + "i_search = 4\n", + "Looking for paths with length: 1 for node GSK3B_S21 and PTPN11\n", + "i_search = 4\n", + "Looking for paths with length: 2 for node GSK3B_S21 and PTPN11\n", + "i_search = 4\n", + "Looking for paths with length: 3 for node GSK3B_S21 and PTPN11\n", + "i_search = 4\n", + "Looking for paths with length: 4 for node GSK3B_S21 and PTPN11\n", + "looking for paths in the network with length: 0 for node GSK3B_S21 and STAT3\n", + "looking for paths in the network with length: 1 for node GSK3B_S21 and STAT3\n", + "looking for paths in the network with length: 2 for node GSK3B_S21 and STAT3\n", + "looking for paths in the network with length: 3 for node GSK3B_S21 and STAT3\n", + "looking for paths in the network with length: 4 for node GSK3B_S21 and STAT3\n", + "looking for paths in the network with length: 5 for node GSK3B_S21 and STAT3\n", + "looking for paths in the network with length: 6 for node GSK3B_S21 and STAT3\n", + "looking for paths in the network with length: 7 for node GSK3B_S21 and STAT3\n", + "looking for paths in the network with length: 8 for node GSK3B_S21 and STAT3\n", + "looking for paths in the network with length: 9 for node GSK3B_S21 and STAT3\n", + "looking for paths in the network with length: 10 for node GSK3B_S21 and STAT3\n", + "i_search = 4\n", + "Looking for paths with length: 0 for node GSK3B_S21 and STAT3\n", + "i_search = 4\n", + "Looking for paths with length: 1 for node GSK3B_S21 and STAT3\n", + "i_search = 4\n", + "Looking for paths with length: 2 for node GSK3B_S21 and STAT3\n", + "i_search = 4\n", + "Looking for paths with length: 3 for node GSK3B_S21 and STAT3\n", + "i_search = 4\n", + "Looking for paths with length: 4 for node GSK3B_S21 and STAT3\n", + "looking for paths in the network with length: 0 for node GSK3B_S21 and CHEK2\n", + "looking for paths in the network with length: 1 for node GSK3B_S21 and CHEK2\n", + "looking for paths in the network with length: 2 for node GSK3B_S21 and CHEK2\n", + "looking for paths in the network with length: 3 for node GSK3B_S21 and CHEK2\n", + "looking for paths in the network with length: 4 for node GSK3B_S21 and CHEK2\n", + "looking for paths in the network with length: 5 for node GSK3B_S21 and CHEK2\n", + "looking for paths in the network with length: 6 for node GSK3B_S21 and CHEK2\n", + "looking for paths in the network with length: 7 for node GSK3B_S21 and CHEK2\n", + "looking for paths in the network with length: 8 for node GSK3B_S21 and CHEK2\n", + "looking for paths in the network with length: 9 for node GSK3B_S21 and CHEK2\n", + "looking for paths in the network with length: 10 for node GSK3B_S21 and CHEK2\n", + "i_search = 4\n", + "Looking for paths with length: 0 for node GSK3B_S21 and CHEK2\n", + "i_search = 4\n", + "Looking for paths with length: 1 for node GSK3B_S21 and CHEK2\n", + "i_search = 4\n", + "Looking for paths with length: 2 for node GSK3B_S21 and CHEK2\n", + "i_search = 4\n", + "Looking for paths with length: 3 for node GSK3B_S21 and CHEK2\n", + "i_search = 4\n", + "Looking for paths with length: 4 for node GSK3B_S21 and CHEK2\n", + "looking for paths in the network with length: 0 for node GSK3B_S21 and RELA\n", + "looking for paths in the network with length: 1 for node GSK3B_S21 and RELA\n", + "looking for paths in the network with length: 2 for node GSK3B_S21 and RELA\n", + "looking for paths in the network with length: 3 for node GSK3B_S21 and RELA\n", + "looking for paths in the network with length: 4 for node GSK3B_S21 and RELA\n", + "looking for paths in the network with length: 5 for node GSK3B_S21 and RELA\n", + "looking for paths in the network with length: 6 for node GSK3B_S21 and RELA\n", + "looking for paths in the network with length: 7 for node GSK3B_S21 and RELA\n", + "looking for paths in the network with length: 8 for node GSK3B_S21 and RELA\n", + "looking for paths in the network with length: 9 for node GSK3B_S21 and RELA\n", + "looking for paths in the network with length: 10 for node GSK3B_S21 and RELA\n", + "i_search = 4\n", + "Looking for paths with length: 0 for node GSK3B_S21 and RELA\n", + "i_search = 4\n", + "Looking for paths with length: 1 for node GSK3B_S21 and RELA\n", + "i_search = 4\n", + "Looking for paths with length: 2 for node GSK3B_S21 and RELA\n", + "i_search = 4\n", + "Looking for paths with length: 3 for node GSK3B_S21 and RELA\n", + "i_search = 4\n", + "Looking for paths with length: 4 for node GSK3B_S21 and RELA\n", + "looking for paths in the network with length: 0 for node GSK3B_S21 and MARCKS\n", + "looking for paths in the network with length: 1 for node GSK3B_S21 and MARCKS\n", + "looking for paths in the network with length: 2 for node GSK3B_S21 and MARCKS\n", + "looking for paths in the network with length: 3 for node GSK3B_S21 and MARCKS\n", + "looking for paths in the network with length: 4 for node GSK3B_S21 and MARCKS\n", + "looking for paths in the network with length: 5 for node GSK3B_S21 and MARCKS\n", + "looking for paths in the network with length: 6 for node GSK3B_S21 and MARCKS\n", + "looking for paths in the network with length: 7 for node GSK3B_S21 and MARCKS\n", + "looking for paths in the network with length: 8 for node GSK3B_S21 and MARCKS\n", + "looking for paths in the network with length: 9 for node GSK3B_S21 and MARCKS\n", + "looking for paths in the network with length: 10 for node GSK3B_S21 and MARCKS\n", + "i_search = 4\n", + "Looking for paths with length: 0 for node GSK3B_S21 and MARCKS\n", + "i_search = 4\n", + "Looking for paths with length: 1 for node GSK3B_S21 and MARCKS\n", + "i_search = 4\n", + "Looking for paths with length: 2 for node GSK3B_S21 and MARCKS\n", + "i_search = 4\n", + "Looking for paths with length: 3 for node GSK3B_S21 and MARCKS\n", + "i_search = 4\n", + "Looking for paths with length: 4 for node GSK3B_S21 and MARCKS\n", + "looking for paths in the network with length: 0 for node AKT1_S473 and HSPB1_S78\n", + "looking for paths in the network with length: 1 for node AKT1_S473 and HSPB1_S78\n", + "looking for paths in the network with length: 2 for node AKT1_S473 and HSPB1_S78\n", + "looking for paths in the network with length: 3 for node AKT1_S473 and HSPB1_S78\n", + "looking for paths in the network with length: 4 for node AKT1_S473 and HSPB1_S78\n", + "looking for paths in the network with length: 5 for node AKT1_S473 and HSPB1_S78\n", + "looking for paths in the network with length: 6 for node AKT1_S473 and HSPB1_S78\n", + "looking for paths in the network with length: 7 for node AKT1_S473 and HSPB1_S78\n", + "looking for paths in the network with length: 8 for node AKT1_S473 and HSPB1_S78\n", + "looking for paths in the network with length: 9 for node AKT1_S473 and HSPB1_S78\n", + "looking for paths in the network with length: 10 for node AKT1_S473 and HSPB1_S78\n", + "i_search = 4\n", + "Looking for paths with length: 0 for node AKT1_S473 and HSPB1_S78\n", + "i_search = 4\n", + "Looking for paths with length: 1 for node AKT1_S473 and HSPB1_S78\n", + "i_search = 4\n", + "Looking for paths with length: 2 for node AKT1_S473 and HSPB1_S78\n", + "i_search = 4\n", + "Looking for paths with length: 3 for node AKT1_S473 and HSPB1_S78\n", + "i_search = 4\n", + "Looking for paths with length: 4 for node AKT1_S473 and HSPB1_S78\n", + "looking for paths in the network with length: 0 for node AKT1_S473 and HSPB1_S82\n", + "looking for paths in the network with length: 1 for node AKT1_S473 and HSPB1_S82\n", + "looking for paths in the network with length: 2 for node AKT1_S473 and HSPB1_S82\n", + "looking for paths in the network with length: 3 for node AKT1_S473 and HSPB1_S82\n", + "looking for paths in the network with length: 4 for node AKT1_S473 and HSPB1_S82\n", + "looking for paths in the network with length: 5 for node AKT1_S473 and HSPB1_S82\n", + "looking for paths in the network with length: 6 for node AKT1_S473 and HSPB1_S82\n", + "looking for paths in the network with length: 7 for node AKT1_S473 and HSPB1_S82\n", + "looking for paths in the network with length: 8 for node AKT1_S473 and HSPB1_S82\n", + "looking for paths in the network with length: 9 for node AKT1_S473 and HSPB1_S82\n", + "looking for paths in the network with length: 10 for node AKT1_S473 and HSPB1_S82\n", + "i_search = 4\n", + "Looking for paths with length: 0 for node AKT1_S473 and HSPB1_S82\n", + "i_search = 4\n", + "Looking for paths with length: 1 for node AKT1_S473 and HSPB1_S82\n", + "i_search = 4\n", + "Looking for paths with length: 2 for node AKT1_S473 and HSPB1_S82\n", + "[['AKT1_S473', 'AKT1', 'HSPB1_S82']]\n", + "AKT1_S473 AKT1\n", + "AKT1 HSPB1_S82\n", + "looking for paths in the network with length: 0 for node AKT1_S473 and MAPK14_T180\n", + "looking for paths in the network with length: 1 for node AKT1_S473 and MAPK14_T180\n", + "looking for paths in the network with length: 2 for node AKT1_S473 and MAPK14_T180\n", + "looking for paths in the network with length: 3 for node AKT1_S473 and MAPK14_T180\n", + "looking for paths in the network with length: 4 for node AKT1_S473 and MAPK14_T180\n", + "looking for paths in the network with length: 5 for node AKT1_S473 and MAPK14_T180\n", + "looking for paths in the network with length: 6 for node AKT1_S473 and MAPK14_T180\n", + "looking for paths in the network with length: 7 for node AKT1_S473 and MAPK14_T180\n", + "looking for paths in the network with length: 8 for node AKT1_S473 and MAPK14_T180\n", + "looking for paths in the network with length: 9 for node AKT1_S473 and MAPK14_T180\n", + "looking for paths in the network with length: 10 for node AKT1_S473 and MAPK14_T180\n", + "i_search = 4\n", + "Looking for paths with length: 0 for node AKT1_S473 and MAPK14_T180\n", + "i_search = 4\n", + "Looking for paths with length: 1 for node AKT1_S473 and MAPK14_T180\n", + "i_search = 4\n", + "Looking for paths with length: 2 for node AKT1_S473 and MAPK14_T180\n", + "i_search = 4\n", + "Looking for paths with length: 3 for node AKT1_S473 and MAPK14_T180\n", + "i_search = 4\n", + "Looking for paths with length: 4 for node AKT1_S473 and MAPK14_T180\n", + "[['AKT1_S473', 'AKT1', 'MAP2K4_S80', 'MAP2K4', 'MAPK14_T180'], ['AKT1_S473', 'AKT1', 'MAP3K5_S83', 'MAP3K5', 'MAPK14_T180'], ['AKT1_S473', 'MAPKAPK2', 'MAPKAPK2_T334', 'MAPK14', 'MAPK14_T180'], ['AKT1_S473', 'MAPKAPK2', 'MAPKAPK2_S272', 'MAPK14', 'MAPK14_T180'], ['AKT1_S473', 'MAPKAPK2', 'MAPKAPK2_T222', 'MAPK14', 'MAPK14_T180']]\n", + "AKT1_S473 AKT1\n", + "AKT1 MAP2K4_S80\n", + "MAP2K4_S80 MAP2K4\n", + "MAP2K4 MAPK14_T180\n", + "AKT1_S473 AKT1\n", + "AKT1 MAP3K5_S83\n", + "MAP3K5_S83 MAP3K5\n", + "MAP3K5 MAPK14_T180\n", + "MAPKAPK2 AKT1_S473\n", + "MAPKAPK2_T334 MAPKAPK2\n", + "MAPK14 MAPKAPK2_T334\n", + "MAPK14_T180 MAPK14\n", + "MAPKAPK2 AKT1_S473\n", + "MAPKAPK2_S272 MAPKAPK2\n", + "MAPK14 MAPKAPK2_S272\n", + "MAPK14_T180 MAPK14\n", + "MAPKAPK2 AKT1_S473\n", + "MAPKAPK2_T222 MAPKAPK2\n", + "MAPK14 MAPKAPK2_T222\n", + "MAPK14_T180 MAPK14\n", + "looking for paths in the network with length: 0 for node AKT1_S473 and MAPK14_Y182\n", + "looking for paths in the network with length: 1 for node AKT1_S473 and MAPK14_Y182\n", + "looking for paths in the network with length: 2 for node AKT1_S473 and MAPK14_Y182\n", + "looking for paths in the network with length: 3 for node AKT1_S473 and MAPK14_Y182\n", + "looking for paths in the network with length: 4 for node AKT1_S473 and MAPK14_Y182\n", + "Found a path!\n", + "[['AKT1_S473', 'MAPKAPK2', 'MAPKAPK2_T334', 'MAPK14', 'MAPK14_Y182'], ['AKT1_S473', 'MAPKAPK2', 'MAPKAPK2_S272', 'MAPK14', 'MAPK14_Y182'], ['AKT1_S473', 'MAPKAPK2', 'MAPKAPK2_T222', 'MAPK14', 'MAPK14_Y182']]\n", + "looking for paths in the network with length: 0 for node AKT1_S473 and MAP2K1_S218\n", + "looking for paths in the network with length: 1 for node AKT1_S473 and MAP2K1_S218\n", + "looking for paths in the network with length: 2 for node AKT1_S473 and MAP2K1_S218\n", + "looking for paths in the network with length: 3 for node AKT1_S473 and MAP2K1_S218\n", + "looking for paths in the network with length: 4 for node AKT1_S473 and MAP2K1_S218\n", + "looking for paths in the network with length: 5 for node AKT1_S473 and MAP2K1_S218\n", + "looking for paths in the network with length: 6 for node AKT1_S473 and MAP2K1_S218\n", + "looking for paths in the network with length: 7 for node AKT1_S473 and MAP2K1_S218\n", + "looking for paths in the network with length: 8 for node AKT1_S473 and MAP2K1_S218\n", + "looking for paths in the network with length: 9 for node AKT1_S473 and MAP2K1_S218\n", + "looking for paths in the network with length: 10 for node AKT1_S473 and MAP2K1_S218\n", + "i_search = 4\n", + "Looking for paths with length: 0 for node AKT1_S473 and MAP2K1_S218\n", + "i_search = 4\n", + "Looking for paths with length: 1 for node AKT1_S473 and MAP2K1_S218\n", + "i_search = 4\n", + "Looking for paths with length: 2 for node AKT1_S473 and MAP2K1_S218\n", + "i_search = 4\n", + "Looking for paths with length: 3 for node AKT1_S473 and MAP2K1_S218\n", + "i_search = 4\n", + "Looking for paths with length: 4 for node AKT1_S473 and MAP2K1_S218\n", + "[['AKT1_S473', 'AKT1', 'RAF1_S259', 'RAF1', 'MAP2K1_S218'], ['AKT1_S473', 'AKT1', 'BRAF_S365', 'BRAF', 'MAP2K1_S218'], ['AKT1_S473', 'AKT1', 'BRAF_S429', 'BRAF', 'MAP2K1_S218']]\n", + "AKT1_S473 AKT1\n", + "AKT1 RAF1_S259\n", + "RAF1_S259 RAF1\n", + "RAF1 MAP2K1_S218\n", + "AKT1_S473 AKT1\n", + "AKT1 BRAF_S365\n", + "BRAF_S365 BRAF\n", + "BRAF MAP2K1_S218\n", + "AKT1_S473 AKT1\n", + "AKT1 BRAF_S429\n", + "BRAF_S429 BRAF\n", + "BRAF MAP2K1_S218\n", + "looking for paths in the network with length: 0 for node AKT1_S473 and MAP2K1_S222\n", + "looking for paths in the network with length: 1 for node AKT1_S473 and MAP2K1_S222\n", + "looking for paths in the network with length: 2 for node AKT1_S473 and MAP2K1_S222\n", + "looking for paths in the network with length: 3 for node AKT1_S473 and MAP2K1_S222\n", + "looking for paths in the network with length: 4 for node AKT1_S473 and MAP2K1_S222\n", + "looking for paths in the network with length: 5 for node AKT1_S473 and MAP2K1_S222\n", + "looking for paths in the network with length: 6 for node AKT1_S473 and MAP2K1_S222\n", + "looking for paths in the network with length: 7 for node AKT1_S473 and MAP2K1_S222\n", + "looking for paths in the network with length: 8 for node AKT1_S473 and MAP2K1_S222\n", + "looking for paths in the network with length: 9 for node AKT1_S473 and MAP2K1_S222\n", + "looking for paths in the network with length: 10 for node AKT1_S473 and MAP2K1_S222\n", + "i_search = 4\n", + "Looking for paths with length: 0 for node AKT1_S473 and MAP2K1_S222\n", + "i_search = 4\n", + "Looking for paths with length: 1 for node AKT1_S473 and MAP2K1_S222\n", + "i_search = 4\n", + "Looking for paths with length: 2 for node AKT1_S473 and MAP2K1_S222\n", + "i_search = 4\n", + "Looking for paths with length: 3 for node AKT1_S473 and MAP2K1_S222\n", + "i_search = 4\n", + "Looking for paths with length: 4 for node AKT1_S473 and MAP2K1_S222\n", + "[['AKT1_S473', 'AKT1', 'RAF1_S259', 'RAF1', 'MAP2K1_S222'], ['AKT1_S473', 'AKT1', 'BRAF_S365', 'BRAF', 'MAP2K1_S222'], ['AKT1_S473', 'AKT1', 'BRAF_S429', 'BRAF', 'MAP2K1_S222']]\n", + "AKT1_S473 AKT1\n", + "AKT1 RAF1_S259\n", + "RAF1_S259 RAF1\n", + "RAF1 MAP2K1_S222\n", + "AKT1_S473 AKT1\n", + "AKT1 BRAF_S365\n", + "BRAF_S365 BRAF\n", + "BRAF MAP2K1_S222\n", + "AKT1_S473 AKT1\n", + "AKT1 BRAF_S429\n", + "BRAF_S429 BRAF\n", + "BRAF MAP2K1_S222\n", + "looking for paths in the network with length: 0 for node AKT1_S473 and RPS6KA1_S380\n", + "looking for paths in the network with length: 1 for node AKT1_S473 and RPS6KA1_S380\n", + "looking for paths in the network with length: 2 for node AKT1_S473 and RPS6KA1_S380\n", + "looking for paths in the network with length: 3 for node AKT1_S473 and RPS6KA1_S380\n", + "looking for paths in the network with length: 4 for node AKT1_S473 and RPS6KA1_S380\n", + "looking for paths in the network with length: 5 for node AKT1_S473 and RPS6KA1_S380\n", + "looking for paths in the network with length: 6 for node AKT1_S473 and RPS6KA1_S380\n", + "looking for paths in the network with length: 7 for node AKT1_S473 and RPS6KA1_S380\n", + "looking for paths in the network with length: 8 for node AKT1_S473 and RPS6KA1_S380\n", + "Found a path!\n", + "[['AKT1_S473', 'AKT1', 'RAF1_S259', 'RAF1', 'MAP2K1_S222', 'MAP2K1', 'MAPK3_T202', 'MAPK3', 'RPS6KA1_S380'], ['AKT1_S473', 'AKT1', 'RAF1_S259', 'RAF1', 'MAP2K1_S218', 'MAP2K1', 'MAPK3_T202', 'MAPK3', 'RPS6KA1_S380'], ['AKT1_S473', 'AKT1', 'BRAF_S429', 'BRAF', 'MAP2K1_S222', 'MAP2K1', 'MAPK3_T202', 'MAPK3', 'RPS6KA1_S380'], ['AKT1_S473', 'AKT1', 'BRAF_S429', 'BRAF', 'MAP2K1_S218', 'MAP2K1', 'MAPK3_T202', 'MAPK3', 'RPS6KA1_S380'], ['AKT1_S473', 'AKT1', 'BRAF_S365', 'BRAF', 'MAP2K1_S222', 'MAP2K1', 'MAPK3_T202', 'MAPK3', 'RPS6KA1_S380'], ['AKT1_S473', 'AKT1', 'BRAF_S365', 'BRAF', 'MAP2K1_S218', 'MAP2K1', 'MAPK3_T202', 'MAPK3', 'RPS6KA1_S380']]\n", + "looking for paths in the network with length: 0 for node AKT1_S473 and CREB1_S133\n", + "looking for paths in the network with length: 1 for node AKT1_S473 and CREB1_S133\n", + "looking for paths in the network with length: 2 for node AKT1_S473 and CREB1_S133\n", + "looking for paths in the network with length: 3 for node AKT1_S473 and CREB1_S133\n", + "looking for paths in the network with length: 4 for node AKT1_S473 and CREB1_S133\n", + "looking for paths in the network with length: 5 for node AKT1_S473 and CREB1_S133\n", + "looking for paths in the network with length: 6 for node AKT1_S473 and CREB1_S133\n", + "looking for paths in the network with length: 7 for node AKT1_S473 and CREB1_S133\n", + "looking for paths in the network with length: 8 for node AKT1_S473 and CREB1_S133\n", + "looking for paths in the network with length: 9 for node AKT1_S473 and CREB1_S133\n", + "looking for paths in the network with length: 10 for node AKT1_S473 and CREB1_S133\n", + "i_search = 4\n", + "Looking for paths with length: 0 for node AKT1_S473 and CREB1_S133\n", + "i_search = 4\n", + "Looking for paths with length: 1 for node AKT1_S473 and CREB1_S133\n", + "i_search = 4\n", + "Looking for paths with length: 2 for node AKT1_S473 and CREB1_S133\n", + "i_search = 4\n", + "Looking for paths with length: 3 for node AKT1_S473 and CREB1_S133\n", + "i_search = 4\n", + "Looking for paths with length: 4 for node AKT1_S473 and CREB1_S133\n", + "looking for paths in the network with length: 0 for node AKT1_S473 and NFKBIA_S32\n", + "looking for paths in the network with length: 1 for node AKT1_S473 and NFKBIA_S32\n", + "looking for paths in the network with length: 2 for node AKT1_S473 and NFKBIA_S32\n", + "looking for paths in the network with length: 3 for node AKT1_S473 and NFKBIA_S32\n", + "looking for paths in the network with length: 4 for node AKT1_S473 and NFKBIA_S32\n", + "looking for paths in the network with length: 5 for node AKT1_S473 and NFKBIA_S32\n", + "looking for paths in the network with length: 6 for node AKT1_S473 and NFKBIA_S32\n", + "looking for paths in the network with length: 7 for node AKT1_S473 and NFKBIA_S32\n", + "looking for paths in the network with length: 8 for node AKT1_S473 and NFKBIA_S32\n", + "looking for paths in the network with length: 9 for node AKT1_S473 and NFKBIA_S32\n", + "looking for paths in the network with length: 10 for node AKT1_S473 and NFKBIA_S32\n", + "i_search = 4\n", + "Looking for paths with length: 0 for node AKT1_S473 and NFKBIA_S32\n", + "i_search = 4\n", + "Looking for paths with length: 1 for node AKT1_S473 and NFKBIA_S32\n", + "i_search = 4\n", + "Looking for paths with length: 2 for node AKT1_S473 and NFKBIA_S32\n", + "i_search = 4\n", + "Looking for paths with length: 3 for node AKT1_S473 and NFKBIA_S32\n", + "i_search = 4\n", + "Looking for paths with length: 4 for node AKT1_S473 and NFKBIA_S32\n", + "[['AKT1_S473', 'AKT1', 'CHUK_T23', 'CHUK', 'NFKBIA_S32'], ['AKT1_S473', 'AKT1', 'RPS6KA3_S19', 'RPS6KA3', 'NFKBIA_S32']]\n", + "AKT1_S473 AKT1\n", + "AKT1 CHUK_T23\n", + "CHUK_T23 CHUK\n", + "CHUK NFKBIA_S32\n", + "AKT1_S473 AKT1\n", + "AKT1 RPS6KA3_S19\n", + "RPS6KA3_S19 RPS6KA3\n", + "RPS6KA3 NFKBIA_S32\n", + "looking for paths in the network with length: 0 for node AKT1_S473 and NFKBIA_S36\n", + "looking for paths in the network with length: 1 for node AKT1_S473 and NFKBIA_S36\n", + "looking for paths in the network with length: 2 for node AKT1_S473 and NFKBIA_S36\n", + "looking for paths in the network with length: 3 for node AKT1_S473 and NFKBIA_S36\n", + "looking for paths in the network with length: 4 for node AKT1_S473 and NFKBIA_S36\n", + "looking for paths in the network with length: 5 for node AKT1_S473 and NFKBIA_S36\n", + "looking for paths in the network with length: 6 for node AKT1_S473 and NFKBIA_S36\n", + "looking for paths in the network with length: 7 for node AKT1_S473 and NFKBIA_S36\n", + "looking for paths in the network with length: 8 for node AKT1_S473 and NFKBIA_S36\n", + "looking for paths in the network with length: 9 for node AKT1_S473 and NFKBIA_S36\n", + "looking for paths in the network with length: 10 for node AKT1_S473 and NFKBIA_S36\n", + "i_search = 4\n", + "Looking for paths with length: 0 for node AKT1_S473 and NFKBIA_S36\n", + "i_search = 4\n", + "Looking for paths with length: 1 for node AKT1_S473 and NFKBIA_S36\n", + "i_search = 4\n", + "Looking for paths with length: 2 for node AKT1_S473 and NFKBIA_S36\n", + "i_search = 4\n", + "Looking for paths with length: 3 for node AKT1_S473 and NFKBIA_S36\n", + "i_search = 4\n", + "Looking for paths with length: 4 for node AKT1_S473 and NFKBIA_S36\n", + "[['AKT1_S473', 'AKT1', 'CHUK_T23', 'CHUK', 'NFKBIA_S36']]\n", + "AKT1_S473 AKT1\n", + "AKT1 CHUK_T23\n", + "CHUK_T23 CHUK\n", + "CHUK NFKBIA_S36\n", + "looking for paths in the network with length: 0 for node AKT1_S473 and MTOR_S2448\n", + "looking for paths in the network with length: 1 for node AKT1_S473 and MTOR_S2448\n", + "looking for paths in the network with length: 2 for node AKT1_S473 and MTOR_S2448\n", + "looking for paths in the network with length: 3 for node AKT1_S473 and MTOR_S2448\n", + "looking for paths in the network with length: 4 for node AKT1_S473 and MTOR_S2448\n", + "looking for paths in the network with length: 5 for node AKT1_S473 and MTOR_S2448\n", + "looking for paths in the network with length: 6 for node AKT1_S473 and MTOR_S2448\n", + "looking for paths in the network with length: 7 for node AKT1_S473 and MTOR_S2448\n", + "looking for paths in the network with length: 8 for node AKT1_S473 and MTOR_S2448\n", + "looking for paths in the network with length: 9 for node AKT1_S473 and MTOR_S2448\n", + "looking for paths in the network with length: 10 for node AKT1_S473 and MTOR_S2448\n", + "i_search = 4\n", + "Looking for paths with length: 0 for node AKT1_S473 and MTOR_S2448\n", + "i_search = 4\n", + "Looking for paths with length: 1 for node AKT1_S473 and MTOR_S2448\n", + "i_search = 4\n", + "Looking for paths with length: 2 for node AKT1_S473 and MTOR_S2448\n", + "[['AKT1_S473', 'AKT1', 'MTOR_S2448'], ['AKT1_S473', 'MTOR', 'MTOR_S2448']]\n", + "AKT1_S473 AKT1\n", + "AKT1 MTOR_S2448\n", + "MTOR AKT1_S473\n", + "MTOR MTOR_S2448\n", + "looking for paths in the network with length: 0 for node AKT1_S473 and JUN_S63\n", + "looking for paths in the network with length: 1 for node AKT1_S473 and JUN_S63\n", + "looking for paths in the network with length: 2 for node AKT1_S473 and JUN_S63\n", + "looking for paths in the network with length: 3 for node AKT1_S473 and JUN_S63\n", + "looking for paths in the network with length: 4 for node AKT1_S473 and JUN_S63\n", + "looking for paths in the network with length: 5 for node AKT1_S473 and JUN_S63\n", + "looking for paths in the network with length: 6 for node AKT1_S473 and JUN_S63\n", + "looking for paths in the network with length: 7 for node AKT1_S473 and JUN_S63\n", + "looking for paths in the network with length: 8 for node AKT1_S473 and JUN_S63\n", + "looking for paths in the network with length: 9 for node AKT1_S473 and JUN_S63\n", + "looking for paths in the network with length: 10 for node AKT1_S473 and JUN_S63\n", + "i_search = 4\n", + "Looking for paths with length: 0 for node AKT1_S473 and JUN_S63\n", + "i_search = 4\n", + "Looking for paths with length: 1 for node AKT1_S473 and JUN_S63\n", + "i_search = 4\n", + "Looking for paths with length: 2 for node AKT1_S473 and JUN_S63\n", + "i_search = 4\n", + "Looking for paths with length: 3 for node AKT1_S473 and JUN_S63\n", + "i_search = 4\n", + "Looking for paths with length: 4 for node AKT1_S473 and JUN_S63\n", + "looking for paths in the network with length: 0 for node AKT1_S473 and EGFR_Y1068\n", + "looking for paths in the network with length: 1 for node AKT1_S473 and EGFR_Y1068\n", + "looking for paths in the network with length: 2 for node AKT1_S473 and EGFR_Y1068\n", + "looking for paths in the network with length: 3 for node AKT1_S473 and EGFR_Y1068\n", + "looking for paths in the network with length: 4 for node AKT1_S473 and EGFR_Y1068\n", + "looking for paths in the network with length: 5 for node AKT1_S473 and EGFR_Y1068\n", + "looking for paths in the network with length: 6 for node AKT1_S473 and EGFR_Y1068\n", + "looking for paths in the network with length: 7 for node AKT1_S473 and EGFR_Y1068\n", + "looking for paths in the network with length: 8 for node AKT1_S473 and EGFR_Y1068\n", + "looking for paths in the network with length: 9 for node AKT1_S473 and EGFR_Y1068\n", + "looking for paths in the network with length: 10 for node AKT1_S473 and EGFR_Y1068\n", + "i_search = 4\n", + "Looking for paths with length: 0 for node AKT1_S473 and EGFR_Y1068\n", + "i_search = 4\n", + "Looking for paths with length: 1 for node AKT1_S473 and EGFR_Y1068\n", + "i_search = 4\n", + "Looking for paths with length: 2 for node AKT1_S473 and EGFR_Y1068\n", + "i_search = 4\n", + "Looking for paths with length: 3 for node AKT1_S473 and EGFR_Y1068\n", + "i_search = 4\n", + "Looking for paths with length: 4 for node AKT1_S473 and EGFR_Y1068\n", + "looking for paths in the network with length: 0 for node AKT1_S473 and MAPK3_T202\n", + "looking for paths in the network with length: 1 for node AKT1_S473 and MAPK3_T202\n", + "looking for paths in the network with length: 2 for node AKT1_S473 and MAPK3_T202\n", + "looking for paths in the network with length: 3 for node AKT1_S473 and MAPK3_T202\n", + "looking for paths in the network with length: 4 for node AKT1_S473 and MAPK3_T202\n", + "looking for paths in the network with length: 5 for node AKT1_S473 and MAPK3_T202\n", + "looking for paths in the network with length: 6 for node AKT1_S473 and MAPK3_T202\n", + "Found a path!\n", + "[['AKT1_S473', 'AKT1', 'RAF1_S259', 'RAF1', 'MAP2K1_S222', 'MAP2K1', 'MAPK3_T202'], ['AKT1_S473', 'AKT1', 'RAF1_S259', 'RAF1', 'MAP2K1_S218', 'MAP2K1', 'MAPK3_T202'], ['AKT1_S473', 'AKT1', 'BRAF_S429', 'BRAF', 'MAP2K1_S222', 'MAP2K1', 'MAPK3_T202'], ['AKT1_S473', 'AKT1', 'BRAF_S429', 'BRAF', 'MAP2K1_S218', 'MAP2K1', 'MAPK3_T202'], ['AKT1_S473', 'AKT1', 'BRAF_S365', 'BRAF', 'MAP2K1_S222', 'MAP2K1', 'MAPK3_T202'], ['AKT1_S473', 'AKT1', 'BRAF_S365', 'BRAF', 'MAP2K1_S218', 'MAP2K1', 'MAPK3_T202']]\n", + "looking for paths in the network with length: 0 for node AKT1_S473 and MAPK3_Y204\n", + "looking for paths in the network with length: 1 for node AKT1_S473 and MAPK3_Y204\n", + "looking for paths in the network with length: 2 for node AKT1_S473 and MAPK3_Y204\n", + "looking for paths in the network with length: 3 for node AKT1_S473 and MAPK3_Y204\n", + "looking for paths in the network with length: 4 for node AKT1_S473 and MAPK3_Y204\n", + "looking for paths in the network with length: 5 for node AKT1_S473 and MAPK3_Y204\n", + "looking for paths in the network with length: 6 for node AKT1_S473 and MAPK3_Y204\n", + "Found a path!\n", + "[['AKT1_S473', 'AKT1', 'RAF1_S259', 'RAF1', 'MAP2K1_S222', 'MAP2K1', 'MAPK3_Y204'], ['AKT1_S473', 'AKT1', 'RAF1_S259', 'RAF1', 'MAP2K1_S218', 'MAP2K1', 'MAPK3_Y204'], ['AKT1_S473', 'AKT1', 'BRAF_S429', 'BRAF', 'MAP2K1_S222', 'MAP2K1', 'MAPK3_Y204'], ['AKT1_S473', 'AKT1', 'BRAF_S429', 'BRAF', 'MAP2K1_S218', 'MAP2K1', 'MAPK3_Y204'], ['AKT1_S473', 'AKT1', 'BRAF_S365', 'BRAF', 'MAP2K1_S222', 'MAP2K1', 'MAPK3_Y204'], ['AKT1_S473', 'AKT1', 'BRAF_S365', 'BRAF', 'MAP2K1_S218', 'MAP2K1', 'MAPK3_Y204']]\n", + "looking for paths in the network with length: 0 for node AKT1_S473 and PTPN11_Y542\n", + "looking for paths in the network with length: 1 for node AKT1_S473 and PTPN11_Y542\n", + "looking for paths in the network with length: 2 for node AKT1_S473 and PTPN11_Y542\n", + "looking for paths in the network with length: 3 for node AKT1_S473 and PTPN11_Y542\n", + "looking for paths in the network with length: 4 for node AKT1_S473 and PTPN11_Y542\n", + "looking for paths in the network with length: 5 for node AKT1_S473 and PTPN11_Y542\n", + "looking for paths in the network with length: 6 for node AKT1_S473 and PTPN11_Y542\n", + "looking for paths in the network with length: 7 for node AKT1_S473 and PTPN11_Y542\n", + "looking for paths in the network with length: 8 for node AKT1_S473 and PTPN11_Y542\n", + "looking for paths in the network with length: 9 for node AKT1_S473 and PTPN11_Y542\n", + "looking for paths in the network with length: 10 for node AKT1_S473 and PTPN11_Y542\n", + "i_search = 4\n", + "Looking for paths with length: 0 for node AKT1_S473 and PTPN11_Y542\n", + "i_search = 4\n", + "Looking for paths with length: 1 for node AKT1_S473 and PTPN11_Y542\n", + "i_search = 4\n", + "Looking for paths with length: 2 for node AKT1_S473 and PTPN11_Y542\n", + "i_search = 4\n", + "Looking for paths with length: 3 for node AKT1_S473 and PTPN11_Y542\n", + "i_search = 4\n", + "Looking for paths with length: 4 for node AKT1_S473 and PTPN11_Y542\n", + "looking for paths in the network with length: 0 for node AKT1_S473 and STAT3_Y705\n", + "looking for paths in the network with length: 1 for node AKT1_S473 and STAT3_Y705\n", + "looking for paths in the network with length: 2 for node AKT1_S473 and STAT3_Y705\n", + "looking for paths in the network with length: 3 for node AKT1_S473 and STAT3_Y705\n", + "looking for paths in the network with length: 4 for node AKT1_S473 and STAT3_Y705\n", + "looking for paths in the network with length: 5 for node AKT1_S473 and STAT3_Y705\n", + "looking for paths in the network with length: 6 for node AKT1_S473 and STAT3_Y705\n", + "Found a path!\n", + "[['AKT1_S473', 'AKT1', 'GSK3B_S9', 'GSK3B', 'SRC_S493', 'SRC', 'STAT3_Y705'], ['AKT1_S473', 'AKT1', 'GSK3B_S9', 'GSK3B', 'SRC_S51', 'SRC', 'STAT3_Y705'], ['AKT1_S473', 'AKT1', 'GSK3B_S9', 'GSK3B', 'SRC_S43', 'SRC', 'STAT3_Y705'], ['AKT1_S473', 'AKT1', 'GSK3B_S9', 'GSK3B', 'SRC_Y419', 'SRC', 'STAT3_Y705']]\n", + "looking for paths in the network with length: 0 for node AKT1_S473 and CHEK2_T68\n", + "looking for paths in the network with length: 1 for node AKT1_S473 and CHEK2_T68\n", + "looking for paths in the network with length: 2 for node AKT1_S473 and CHEK2_T68\n", + "looking for paths in the network with length: 3 for node AKT1_S473 and CHEK2_T68\n", + "looking for paths in the network with length: 4 for node AKT1_S473 and CHEK2_T68\n", + "looking for paths in the network with length: 5 for node AKT1_S473 and CHEK2_T68\n", + "looking for paths in the network with length: 6 for node AKT1_S473 and CHEK2_T68\n", + "looking for paths in the network with length: 7 for node AKT1_S473 and CHEK2_T68\n", + "looking for paths in the network with length: 8 for node AKT1_S473 and CHEK2_T68\n", + "looking for paths in the network with length: 9 for node AKT1_S473 and CHEK2_T68\n", + "looking for paths in the network with length: 10 for node AKT1_S473 and CHEK2_T68\n", + "i_search = 4\n", + "Looking for paths with length: 0 for node AKT1_S473 and CHEK2_T68\n", + "i_search = 4\n", + "Looking for paths with length: 1 for node AKT1_S473 and CHEK2_T68\n", + "i_search = 4\n", + "Looking for paths with length: 2 for node AKT1_S473 and CHEK2_T68\n", + "i_search = 4\n", + "Looking for paths with length: 3 for node AKT1_S473 and CHEK2_T68\n", + "i_search = 4\n", + "Looking for paths with length: 4 for node AKT1_S473 and CHEK2_T68\n", + "looking for paths in the network with length: 0 for node AKT1_S473 and RELA_S536\n", + "looking for paths in the network with length: 1 for node AKT1_S473 and RELA_S536\n", + "looking for paths in the network with length: 2 for node AKT1_S473 and RELA_S536\n", + "looking for paths in the network with length: 3 for node AKT1_S473 and RELA_S536\n", + "looking for paths in the network with length: 4 for node AKT1_S473 and RELA_S536\n", + "looking for paths in the network with length: 5 for node AKT1_S473 and RELA_S536\n", + "looking for paths in the network with length: 6 for node AKT1_S473 and RELA_S536\n", + "Found a path!\n", + "[['AKT1_S473', 'AKT1', 'GSK3B_S9', 'GSK3B', 'TBK1_S172', 'TBK1', 'RELA_S536']]\n", + "looking for paths in the network with length: 0 for node AKT1_S473 and MARCKS_S170\n", + "looking for paths in the network with length: 1 for node AKT1_S473 and MARCKS_S170\n", + "looking for paths in the network with length: 2 for node AKT1_S473 and MARCKS_S170\n", + "looking for paths in the network with length: 3 for node AKT1_S473 and MARCKS_S170\n", + "looking for paths in the network with length: 4 for node AKT1_S473 and MARCKS_S170\n", + "looking for paths in the network with length: 5 for node AKT1_S473 and MARCKS_S170\n", + "looking for paths in the network with length: 6 for node AKT1_S473 and MARCKS_S170\n", + "looking for paths in the network with length: 7 for node AKT1_S473 and MARCKS_S170\n", + "looking for paths in the network with length: 8 for node AKT1_S473 and MARCKS_S170\n", + "looking for paths in the network with length: 9 for node AKT1_S473 and MARCKS_S170\n", + "looking for paths in the network with length: 10 for node AKT1_S473 and MARCKS_S170\n", + "i_search = 4\n", + "Looking for paths with length: 0 for node AKT1_S473 and MARCKS_S170\n", + "i_search = 4\n", + "Looking for paths with length: 1 for node AKT1_S473 and MARCKS_S170\n", + "i_search = 4\n", + "Looking for paths with length: 2 for node AKT1_S473 and MARCKS_S170\n", + "i_search = 4\n", + "Looking for paths with length: 3 for node AKT1_S473 and MARCKS_S170\n", + "i_search = 4\n", + "Looking for paths with length: 4 for node AKT1_S473 and MARCKS_S170\n", + "looking for paths in the network with length: 0 for node AKT1_S473 and SMAD3\n", + "looking for paths in the network with length: 1 for node AKT1_S473 and SMAD3\n", + "looking for paths in the network with length: 2 for node AKT1_S473 and SMAD3\n", + "looking for paths in the network with length: 3 for node AKT1_S473 and SMAD3\n", + "looking for paths in the network with length: 4 for node AKT1_S473 and SMAD3\n", + "looking for paths in the network with length: 5 for node AKT1_S473 and SMAD3\n", + "looking for paths in the network with length: 6 for node AKT1_S473 and SMAD3\n", + "looking for paths in the network with length: 7 for node AKT1_S473 and SMAD3\n", + "looking for paths in the network with length: 8 for node AKT1_S473 and SMAD3\n", + "looking for paths in the network with length: 9 for node AKT1_S473 and SMAD3\n", + "looking for paths in the network with length: 10 for node AKT1_S473 and SMAD3\n", + "i_search = 4\n", + "Looking for paths with length: 0 for node AKT1_S473 and SMAD3\n", + "i_search = 4\n", + "Looking for paths with length: 1 for node AKT1_S473 and SMAD3\n", + "i_search = 4\n", + "Looking for paths with length: 2 for node AKT1_S473 and SMAD3\n", + "i_search = 4\n", + "Looking for paths with length: 3 for node AKT1_S473 and SMAD3\n", + "i_search = 4\n", + "Looking for paths with length: 4 for node AKT1_S473 and SMAD3\n", + "looking for paths in the network with length: 0 for node AKT1_S473 and TP53\n", + "looking for paths in the network with length: 1 for node AKT1_S473 and TP53\n", + "looking for paths in the network with length: 2 for node AKT1_S473 and TP53\n", + "looking for paths in the network with length: 3 for node AKT1_S473 and TP53\n", + "looking for paths in the network with length: 4 for node AKT1_S473 and TP53\n", + "looking for paths in the network with length: 5 for node AKT1_S473 and TP53\n", + "looking for paths in the network with length: 6 for node AKT1_S473 and TP53\n", + "looking for paths in the network with length: 7 for node AKT1_S473 and TP53\n", + "looking for paths in the network with length: 8 for node AKT1_S473 and TP53\n", + "looking for paths in the network with length: 9 for node AKT1_S473 and TP53\n", + "looking for paths in the network with length: 10 for node AKT1_S473 and TP53\n", + "i_search = 4\n", + "Looking for paths with length: 0 for node AKT1_S473 and TP53\n", + "i_search = 4\n", + "Looking for paths with length: 1 for node AKT1_S473 and TP53\n", + "i_search = 4\n", + "Looking for paths with length: 2 for node AKT1_S473 and TP53\n", + "i_search = 4\n", + "Looking for paths with length: 3 for node AKT1_S473 and TP53\n", + "i_search = 4\n", + "Looking for paths with length: 4 for node AKT1_S473 and TP53\n", + "looking for paths in the network with length: 0 for node AKT1_S473 and AKT1S1\n", + "looking for paths in the network with length: 1 for node AKT1_S473 and AKT1S1\n", + "looking for paths in the network with length: 2 for node AKT1_S473 and AKT1S1\n", + "looking for paths in the network with length: 3 for node AKT1_S473 and AKT1S1\n", + "looking for paths in the network with length: 4 for node AKT1_S473 and AKT1S1\n", + "looking for paths in the network with length: 5 for node AKT1_S473 and AKT1S1\n", + "looking for paths in the network with length: 6 for node AKT1_S473 and AKT1S1\n", + "looking for paths in the network with length: 7 for node AKT1_S473 and AKT1S1\n", + "looking for paths in the network with length: 8 for node AKT1_S473 and AKT1S1\n", + "looking for paths in the network with length: 9 for node AKT1_S473 and AKT1S1\n", + "looking for paths in the network with length: 10 for node AKT1_S473 and AKT1S1\n", + "i_search = 4\n", + "Looking for paths with length: 0 for node AKT1_S473 and AKT1S1\n", + "i_search = 4\n", + "Looking for paths with length: 1 for node AKT1_S473 and AKT1S1\n", + "i_search = 4\n", + "Looking for paths with length: 2 for node AKT1_S473 and AKT1S1\n", + "i_search = 4\n", + "Looking for paths with length: 3 for node AKT1_S473 and AKT1S1\n", + "i_search = 4\n", + "Looking for paths with length: 4 for node AKT1_S473 and AKT1S1\n", + "looking for paths in the network with length: 0 for node AKT1_S473 and GSK3B\n", + "looking for paths in the network with length: 1 for node AKT1_S473 and GSK3B\n", + "looking for paths in the network with length: 2 for node AKT1_S473 and GSK3B\n", + "looking for paths in the network with length: 3 for node AKT1_S473 and GSK3B\n", + "looking for paths in the network with length: 4 for node AKT1_S473 and GSK3B\n", + "looking for paths in the network with length: 5 for node AKT1_S473 and GSK3B\n", + "looking for paths in the network with length: 6 for node AKT1_S473 and GSK3B\n", + "looking for paths in the network with length: 7 for node AKT1_S473 and GSK3B\n", + "looking for paths in the network with length: 8 for node AKT1_S473 and GSK3B\n", + "looking for paths in the network with length: 9 for node AKT1_S473 and GSK3B\n", + "looking for paths in the network with length: 10 for node AKT1_S473 and GSK3B\n", + "i_search = 4\n", + "Looking for paths with length: 0 for node AKT1_S473 and GSK3B\n", + "i_search = 4\n", + "Looking for paths with length: 1 for node AKT1_S473 and GSK3B\n", + "i_search = 4\n", + "Looking for paths with length: 2 for node AKT1_S473 and GSK3B\n", + "i_search = 4\n", + "Looking for paths with length: 3 for node AKT1_S473 and GSK3B\n", + "i_search = 4\n", + "Looking for paths with length: 4 for node AKT1_S473 and GSK3B\n", + "looking for paths in the network with length: 0 for node AKT1_S473 and AKT1\n", + "looking for paths in the network with length: 1 for node AKT1_S473 and AKT1\n", + "looking for paths in the network with length: 2 for node AKT1_S473 and AKT1\n", + "looking for paths in the network with length: 3 for node AKT1_S473 and AKT1\n", + "looking for paths in the network with length: 4 for node AKT1_S473 and AKT1\n", + "looking for paths in the network with length: 5 for node AKT1_S473 and AKT1\n", + "looking for paths in the network with length: 6 for node AKT1_S473 and AKT1\n", + "looking for paths in the network with length: 7 for node AKT1_S473 and AKT1\n", + "looking for paths in the network with length: 8 for node AKT1_S473 and AKT1\n", + "looking for paths in the network with length: 9 for node AKT1_S473 and AKT1\n", + "looking for paths in the network with length: 10 for node AKT1_S473 and AKT1\n", + "i_search = 4\n", + "Looking for paths with length: 0 for node AKT1_S473 and AKT1\n", + "i_search = 4\n", + "Looking for paths with length: 1 for node AKT1_S473 and AKT1\n", + "i_search = 4\n", + "Looking for paths with length: 2 for node AKT1_S473 and AKT1\n", + "i_search = 4\n", + "Looking for paths with length: 3 for node AKT1_S473 and AKT1\n", + "i_search = 4\n", + "Looking for paths with length: 4 for node AKT1_S473 and AKT1\n", + "looking for paths in the network with length: 0 for node AKT1_S473 and HSPB1\n", + "looking for paths in the network with length: 1 for node AKT1_S473 and HSPB1\n", + "looking for paths in the network with length: 2 for node AKT1_S473 and HSPB1\n", + "looking for paths in the network with length: 3 for node AKT1_S473 and HSPB1\n", + "looking for paths in the network with length: 4 for node AKT1_S473 and HSPB1\n", + "looking for paths in the network with length: 5 for node AKT1_S473 and HSPB1\n", + "looking for paths in the network with length: 6 for node AKT1_S473 and HSPB1\n", + "looking for paths in the network with length: 7 for node AKT1_S473 and HSPB1\n", + "looking for paths in the network with length: 8 for node AKT1_S473 and HSPB1\n", + "looking for paths in the network with length: 9 for node AKT1_S473 and HSPB1\n", + "looking for paths in the network with length: 10 for node AKT1_S473 and HSPB1\n", + "i_search = 4\n", + "Looking for paths with length: 0 for node AKT1_S473 and HSPB1\n", + "i_search = 4\n", + "Looking for paths with length: 1 for node AKT1_S473 and HSPB1\n", + "i_search = 4\n", + "Looking for paths with length: 2 for node AKT1_S473 and HSPB1\n", + "i_search = 4\n", + "Looking for paths with length: 3 for node AKT1_S473 and HSPB1\n", + "i_search = 4\n", + "Looking for paths with length: 4 for node AKT1_S473 and HSPB1\n", + "looking for paths in the network with length: 0 for node AKT1_S473 and MAPK14\n", + "looking for paths in the network with length: 1 for node AKT1_S473 and MAPK14\n", + "looking for paths in the network with length: 2 for node AKT1_S473 and MAPK14\n", + "looking for paths in the network with length: 3 for node AKT1_S473 and MAPK14\n", + "looking for paths in the network with length: 4 for node AKT1_S473 and MAPK14\n", + "looking for paths in the network with length: 5 for node AKT1_S473 and MAPK14\n", + "looking for paths in the network with length: 6 for node AKT1_S473 and MAPK14\n", + "looking for paths in the network with length: 7 for node AKT1_S473 and MAPK14\n", + "looking for paths in the network with length: 8 for node AKT1_S473 and MAPK14\n", + "looking for paths in the network with length: 9 for node AKT1_S473 and MAPK14\n", + "looking for paths in the network with length: 10 for node AKT1_S473 and MAPK14\n", + "i_search = 4\n", + "Looking for paths with length: 0 for node AKT1_S473 and MAPK14\n", + "i_search = 4\n", + "Looking for paths with length: 1 for node AKT1_S473 and MAPK14\n", + "i_search = 4\n", + "Looking for paths with length: 2 for node AKT1_S473 and MAPK14\n", + "i_search = 4\n", + "Looking for paths with length: 3 for node AKT1_S473 and MAPK14\n", + "i_search = 4\n", + "Looking for paths with length: 4 for node AKT1_S473 and MAPK14\n", + "looking for paths in the network with length: 0 for node AKT1_S473 and MAP2K1\n", + "looking for paths in the network with length: 1 for node AKT1_S473 and MAP2K1\n", + "looking for paths in the network with length: 2 for node AKT1_S473 and MAP2K1\n", + "looking for paths in the network with length: 3 for node AKT1_S473 and MAP2K1\n", + "looking for paths in the network with length: 4 for node AKT1_S473 and MAP2K1\n", + "looking for paths in the network with length: 5 for node AKT1_S473 and MAP2K1\n", + "looking for paths in the network with length: 6 for node AKT1_S473 and MAP2K1\n", + "looking for paths in the network with length: 7 for node AKT1_S473 and MAP2K1\n", + "looking for paths in the network with length: 8 for node AKT1_S473 and MAP2K1\n", + "looking for paths in the network with length: 9 for node AKT1_S473 and MAP2K1\n", + "looking for paths in the network with length: 10 for node AKT1_S473 and MAP2K1\n", + "i_search = 4\n", + "Looking for paths with length: 0 for node AKT1_S473 and MAP2K1\n", + "i_search = 4\n", + "Looking for paths with length: 1 for node AKT1_S473 and MAP2K1\n", + "i_search = 4\n", + "Looking for paths with length: 2 for node AKT1_S473 and MAP2K1\n", + "i_search = 4\n", + "Looking for paths with length: 3 for node AKT1_S473 and MAP2K1\n", + "i_search = 4\n", + "Looking for paths with length: 4 for node AKT1_S473 and MAP2K1\n", + "looking for paths in the network with length: 0 for node AKT1_S473 and RPS6KA1\n", + "looking for paths in the network with length: 1 for node AKT1_S473 and RPS6KA1\n", + "looking for paths in the network with length: 2 for node AKT1_S473 and RPS6KA1\n", + "looking for paths in the network with length: 3 for node AKT1_S473 and RPS6KA1\n", + "looking for paths in the network with length: 4 for node AKT1_S473 and RPS6KA1\n", + "looking for paths in the network with length: 5 for node AKT1_S473 and RPS6KA1\n", + "looking for paths in the network with length: 6 for node AKT1_S473 and RPS6KA1\n", + "looking for paths in the network with length: 7 for node AKT1_S473 and RPS6KA1\n", + "looking for paths in the network with length: 8 for node AKT1_S473 and RPS6KA1\n", + "looking for paths in the network with length: 9 for node AKT1_S473 and RPS6KA1\n", + "looking for paths in the network with length: 10 for node AKT1_S473 and RPS6KA1\n", + "i_search = 4\n", + "Looking for paths with length: 0 for node AKT1_S473 and RPS6KA1\n", + "i_search = 4\n", + "Looking for paths with length: 1 for node AKT1_S473 and RPS6KA1\n", + "i_search = 4\n", + "Looking for paths with length: 2 for node AKT1_S473 and RPS6KA1\n", + "i_search = 4\n", + "Looking for paths with length: 3 for node AKT1_S473 and RPS6KA1\n", + "i_search = 4\n", + "Looking for paths with length: 4 for node AKT1_S473 and RPS6KA1\n", + "looking for paths in the network with length: 0 for node AKT1_S473 and CREB1\n", + "looking for paths in the network with length: 1 for node AKT1_S473 and CREB1\n", + "looking for paths in the network with length: 2 for node AKT1_S473 and CREB1\n", + "looking for paths in the network with length: 3 for node AKT1_S473 and CREB1\n", + "looking for paths in the network with length: 4 for node AKT1_S473 and CREB1\n", + "looking for paths in the network with length: 5 for node AKT1_S473 and CREB1\n", + "looking for paths in the network with length: 6 for node AKT1_S473 and CREB1\n", + "looking for paths in the network with length: 7 for node AKT1_S473 and CREB1\n", + "looking for paths in the network with length: 8 for node AKT1_S473 and CREB1\n", + "looking for paths in the network with length: 9 for node AKT1_S473 and CREB1\n", + "looking for paths in the network with length: 10 for node AKT1_S473 and CREB1\n", + "i_search = 4\n", + "Looking for paths with length: 0 for node AKT1_S473 and CREB1\n", + "i_search = 4\n", + "Looking for paths with length: 1 for node AKT1_S473 and CREB1\n", + "i_search = 4\n", + "Looking for paths with length: 2 for node AKT1_S473 and CREB1\n", + "i_search = 4\n", + "Looking for paths with length: 3 for node AKT1_S473 and CREB1\n", + "i_search = 4\n", + "Looking for paths with length: 4 for node AKT1_S473 and CREB1\n", + "looking for paths in the network with length: 0 for node AKT1_S473 and NFKBIA\n", + "looking for paths in the network with length: 1 for node AKT1_S473 and NFKBIA\n", + "looking for paths in the network with length: 2 for node AKT1_S473 and NFKBIA\n", + "looking for paths in the network with length: 3 for node AKT1_S473 and NFKBIA\n", + "looking for paths in the network with length: 4 for node AKT1_S473 and NFKBIA\n", + "looking for paths in the network with length: 5 for node AKT1_S473 and NFKBIA\n", + "looking for paths in the network with length: 6 for node AKT1_S473 and NFKBIA\n", + "looking for paths in the network with length: 7 for node AKT1_S473 and NFKBIA\n", + "looking for paths in the network with length: 8 for node AKT1_S473 and NFKBIA\n", + "looking for paths in the network with length: 9 for node AKT1_S473 and NFKBIA\n", + "looking for paths in the network with length: 10 for node AKT1_S473 and NFKBIA\n", + "i_search = 4\n", + "Looking for paths with length: 0 for node AKT1_S473 and NFKBIA\n", + "i_search = 4\n", + "Looking for paths with length: 1 for node AKT1_S473 and NFKBIA\n", + "i_search = 4\n", + "Looking for paths with length: 2 for node AKT1_S473 and NFKBIA\n", + "i_search = 4\n", + "Looking for paths with length: 3 for node AKT1_S473 and NFKBIA\n", + "i_search = 4\n", + "Looking for paths with length: 4 for node AKT1_S473 and NFKBIA\n", + "looking for paths in the network with length: 0 for node AKT1_S473 and MTOR\n", + "looking for paths in the network with length: 1 for node AKT1_S473 and MTOR\n", + "looking for paths in the network with length: 2 for node AKT1_S473 and MTOR\n", + "looking for paths in the network with length: 3 for node AKT1_S473 and MTOR\n", + "looking for paths in the network with length: 4 for node AKT1_S473 and MTOR\n", + "looking for paths in the network with length: 5 for node AKT1_S473 and MTOR\n", + "looking for paths in the network with length: 6 for node AKT1_S473 and MTOR\n", + "looking for paths in the network with length: 7 for node AKT1_S473 and MTOR\n", + "looking for paths in the network with length: 8 for node AKT1_S473 and MTOR\n", + "looking for paths in the network with length: 9 for node AKT1_S473 and MTOR\n", + "looking for paths in the network with length: 10 for node AKT1_S473 and MTOR\n", + "i_search = 4\n", + "Looking for paths with length: 0 for node AKT1_S473 and MTOR\n", + "i_search = 4\n", + "Looking for paths with length: 1 for node AKT1_S473 and MTOR\n", + "i_search = 4\n", + "Looking for paths with length: 2 for node AKT1_S473 and MTOR\n", + "i_search = 4\n", + "Looking for paths with length: 3 for node AKT1_S473 and MTOR\n", + "i_search = 4\n", + "Looking for paths with length: 4 for node AKT1_S473 and MTOR\n", + "looking for paths in the network with length: 0 for node AKT1_S473 and JUN\n", + "looking for paths in the network with length: 1 for node AKT1_S473 and JUN\n", + "looking for paths in the network with length: 2 for node AKT1_S473 and JUN\n", + "looking for paths in the network with length: 3 for node AKT1_S473 and JUN\n", + "looking for paths in the network with length: 4 for node AKT1_S473 and JUN\n", + "looking for paths in the network with length: 5 for node AKT1_S473 and JUN\n", + "looking for paths in the network with length: 6 for node AKT1_S473 and JUN\n", + "looking for paths in the network with length: 7 for node AKT1_S473 and JUN\n", + "looking for paths in the network with length: 8 for node AKT1_S473 and JUN\n", + "looking for paths in the network with length: 9 for node AKT1_S473 and JUN\n", + "looking for paths in the network with length: 10 for node AKT1_S473 and JUN\n", + "i_search = 4\n", + "Looking for paths with length: 0 for node AKT1_S473 and JUN\n", + "i_search = 4\n", + "Looking for paths with length: 1 for node AKT1_S473 and JUN\n", + "i_search = 4\n", + "Looking for paths with length: 2 for node AKT1_S473 and JUN\n", + "i_search = 4\n", + "Looking for paths with length: 3 for node AKT1_S473 and JUN\n", + "i_search = 4\n", + "Looking for paths with length: 4 for node AKT1_S473 and JUN\n", + "looking for paths in the network with length: 0 for node AKT1_S473 and EGFR\n", + "looking for paths in the network with length: 1 for node AKT1_S473 and EGFR\n", + "looking for paths in the network with length: 2 for node AKT1_S473 and EGFR\n", + "looking for paths in the network with length: 3 for node AKT1_S473 and EGFR\n", + "looking for paths in the network with length: 4 for node AKT1_S473 and EGFR\n", + "looking for paths in the network with length: 5 for node AKT1_S473 and EGFR\n", + "looking for paths in the network with length: 6 for node AKT1_S473 and EGFR\n", + "looking for paths in the network with length: 7 for node AKT1_S473 and EGFR\n", + "looking for paths in the network with length: 8 for node AKT1_S473 and EGFR\n", + "looking for paths in the network with length: 9 for node AKT1_S473 and EGFR\n", + "looking for paths in the network with length: 10 for node AKT1_S473 and EGFR\n", + "i_search = 4\n", + "Looking for paths with length: 0 for node AKT1_S473 and EGFR\n", + "i_search = 4\n", + "Looking for paths with length: 1 for node AKT1_S473 and EGFR\n", + "i_search = 4\n", + "Looking for paths with length: 2 for node AKT1_S473 and EGFR\n", + "i_search = 4\n", + "Looking for paths with length: 3 for node AKT1_S473 and EGFR\n", + "i_search = 4\n", + "Looking for paths with length: 4 for node AKT1_S473 and EGFR\n", + "looking for paths in the network with length: 0 for node AKT1_S473 and MAPK3\n", + "looking for paths in the network with length: 1 for node AKT1_S473 and MAPK3\n", + "looking for paths in the network with length: 2 for node AKT1_S473 and MAPK3\n", + "looking for paths in the network with length: 3 for node AKT1_S473 and MAPK3\n", + "looking for paths in the network with length: 4 for node AKT1_S473 and MAPK3\n", + "looking for paths in the network with length: 5 for node AKT1_S473 and MAPK3\n", + "looking for paths in the network with length: 6 for node AKT1_S473 and MAPK3\n", + "looking for paths in the network with length: 7 for node AKT1_S473 and MAPK3\n", + "looking for paths in the network with length: 8 for node AKT1_S473 and MAPK3\n", + "looking for paths in the network with length: 9 for node AKT1_S473 and MAPK3\n", + "looking for paths in the network with length: 10 for node AKT1_S473 and MAPK3\n", + "i_search = 4\n", + "Looking for paths with length: 0 for node AKT1_S473 and MAPK3\n", + "i_search = 4\n", + "Looking for paths with length: 1 for node AKT1_S473 and MAPK3\n", + "i_search = 4\n", + "Looking for paths with length: 2 for node AKT1_S473 and MAPK3\n", + "i_search = 4\n", + "Looking for paths with length: 3 for node AKT1_S473 and MAPK3\n", + "i_search = 4\n", + "Looking for paths with length: 4 for node AKT1_S473 and MAPK3\n", + "looking for paths in the network with length: 0 for node AKT1_S473 and PTPN11\n", + "looking for paths in the network with length: 1 for node AKT1_S473 and PTPN11\n", + "looking for paths in the network with length: 2 for node AKT1_S473 and PTPN11\n", + "looking for paths in the network with length: 3 for node AKT1_S473 and PTPN11\n", + "looking for paths in the network with length: 4 for node AKT1_S473 and PTPN11\n", + "looking for paths in the network with length: 5 for node AKT1_S473 and PTPN11\n", + "looking for paths in the network with length: 6 for node AKT1_S473 and PTPN11\n", + "looking for paths in the network with length: 7 for node AKT1_S473 and PTPN11\n", + "looking for paths in the network with length: 8 for node AKT1_S473 and PTPN11\n", + "looking for paths in the network with length: 9 for node AKT1_S473 and PTPN11\n", + "looking for paths in the network with length: 10 for node AKT1_S473 and PTPN11\n", + "i_search = 4\n", + "Looking for paths with length: 0 for node AKT1_S473 and PTPN11\n", + "i_search = 4\n", + "Looking for paths with length: 1 for node AKT1_S473 and PTPN11\n", + "i_search = 4\n", + "Looking for paths with length: 2 for node AKT1_S473 and PTPN11\n", + "i_search = 4\n", + "Looking for paths with length: 3 for node AKT1_S473 and PTPN11\n", + "i_search = 4\n", + "Looking for paths with length: 4 for node AKT1_S473 and PTPN11\n", + "looking for paths in the network with length: 0 for node AKT1_S473 and STAT3\n", + "looking for paths in the network with length: 1 for node AKT1_S473 and STAT3\n", + "looking for paths in the network with length: 2 for node AKT1_S473 and STAT3\n", + "looking for paths in the network with length: 3 for node AKT1_S473 and STAT3\n", + "looking for paths in the network with length: 4 for node AKT1_S473 and STAT3\n", + "looking for paths in the network with length: 5 for node AKT1_S473 and STAT3\n", + "looking for paths in the network with length: 6 for node AKT1_S473 and STAT3\n", + "looking for paths in the network with length: 7 for node AKT1_S473 and STAT3\n", + "looking for paths in the network with length: 8 for node AKT1_S473 and STAT3\n", + "looking for paths in the network with length: 9 for node AKT1_S473 and STAT3\n", + "looking for paths in the network with length: 10 for node AKT1_S473 and STAT3\n", + "i_search = 4\n", + "Looking for paths with length: 0 for node AKT1_S473 and STAT3\n", + "i_search = 4\n", + "Looking for paths with length: 1 for node AKT1_S473 and STAT3\n", + "i_search = 4\n", + "Looking for paths with length: 2 for node AKT1_S473 and STAT3\n", + "i_search = 4\n", + "Looking for paths with length: 3 for node AKT1_S473 and STAT3\n", + "i_search = 4\n", + "Looking for paths with length: 4 for node AKT1_S473 and STAT3\n", + "looking for paths in the network with length: 0 for node AKT1_S473 and CHEK2\n", + "looking for paths in the network with length: 1 for node AKT1_S473 and CHEK2\n", + "looking for paths in the network with length: 2 for node AKT1_S473 and CHEK2\n", + "looking for paths in the network with length: 3 for node AKT1_S473 and CHEK2\n", + "looking for paths in the network with length: 4 for node AKT1_S473 and CHEK2\n", + "looking for paths in the network with length: 5 for node AKT1_S473 and CHEK2\n", + "looking for paths in the network with length: 6 for node AKT1_S473 and CHEK2\n", + "looking for paths in the network with length: 7 for node AKT1_S473 and CHEK2\n", + "looking for paths in the network with length: 8 for node AKT1_S473 and CHEK2\n", + "looking for paths in the network with length: 9 for node AKT1_S473 and CHEK2\n", + "looking for paths in the network with length: 10 for node AKT1_S473 and CHEK2\n", + "i_search = 4\n", + "Looking for paths with length: 0 for node AKT1_S473 and CHEK2\n", + "i_search = 4\n", + "Looking for paths with length: 1 for node AKT1_S473 and CHEK2\n", + "i_search = 4\n", + "Looking for paths with length: 2 for node AKT1_S473 and CHEK2\n", + "i_search = 4\n", + "Looking for paths with length: 3 for node AKT1_S473 and CHEK2\n", + "i_search = 4\n", + "Looking for paths with length: 4 for node AKT1_S473 and CHEK2\n", + "looking for paths in the network with length: 0 for node AKT1_S473 and RELA\n", + "looking for paths in the network with length: 1 for node AKT1_S473 and RELA\n", + "looking for paths in the network with length: 2 for node AKT1_S473 and RELA\n", + "looking for paths in the network with length: 3 for node AKT1_S473 and RELA\n", + "looking for paths in the network with length: 4 for node AKT1_S473 and RELA\n", + "looking for paths in the network with length: 5 for node AKT1_S473 and RELA\n", + "looking for paths in the network with length: 6 for node AKT1_S473 and RELA\n", + "looking for paths in the network with length: 7 for node AKT1_S473 and RELA\n", + "looking for paths in the network with length: 8 for node AKT1_S473 and RELA\n", + "looking for paths in the network with length: 9 for node AKT1_S473 and RELA\n", + "looking for paths in the network with length: 10 for node AKT1_S473 and RELA\n", + "i_search = 4\n", + "Looking for paths with length: 0 for node AKT1_S473 and RELA\n", + "i_search = 4\n", + "Looking for paths with length: 1 for node AKT1_S473 and RELA\n", + "i_search = 4\n", + "Looking for paths with length: 2 for node AKT1_S473 and RELA\n", + "i_search = 4\n", + "Looking for paths with length: 3 for node AKT1_S473 and RELA\n", + "i_search = 4\n", + "Looking for paths with length: 4 for node AKT1_S473 and RELA\n", + "looking for paths in the network with length: 0 for node AKT1_S473 and MARCKS\n", + "looking for paths in the network with length: 1 for node AKT1_S473 and MARCKS\n", + "looking for paths in the network with length: 2 for node AKT1_S473 and MARCKS\n", + "looking for paths in the network with length: 3 for node AKT1_S473 and MARCKS\n", + "looking for paths in the network with length: 4 for node AKT1_S473 and MARCKS\n", + "looking for paths in the network with length: 5 for node AKT1_S473 and MARCKS\n", + "looking for paths in the network with length: 6 for node AKT1_S473 and MARCKS\n", + "looking for paths in the network with length: 7 for node AKT1_S473 and MARCKS\n", + "looking for paths in the network with length: 8 for node AKT1_S473 and MARCKS\n", + "looking for paths in the network with length: 9 for node AKT1_S473 and MARCKS\n", + "looking for paths in the network with length: 10 for node AKT1_S473 and MARCKS\n", + "i_search = 4\n", + "Looking for paths with length: 0 for node AKT1_S473 and MARCKS\n", + "i_search = 4\n", + "Looking for paths with length: 1 for node AKT1_S473 and MARCKS\n", + "i_search = 4\n", + "Looking for paths with length: 2 for node AKT1_S473 and MARCKS\n", + "i_search = 4\n", + "Looking for paths with length: 3 for node AKT1_S473 and MARCKS\n", + "i_search = 4\n", + "Looking for paths with length: 4 for node AKT1_S473 and MARCKS\n", + "looking for paths in the network with length: 0 for node HSPB1_S78 and HSPB1_S82\n", + "looking for paths in the network with length: 1 for node HSPB1_S78 and HSPB1_S82\n", + "looking for paths in the network with length: 2 for node HSPB1_S78 and HSPB1_S82\n", + "looking for paths in the network with length: 3 for node HSPB1_S78 and HSPB1_S82\n", + "looking for paths in the network with length: 4 for node HSPB1_S78 and HSPB1_S82\n", + "looking for paths in the network with length: 5 for node HSPB1_S78 and HSPB1_S82\n", + "looking for paths in the network with length: 6 for node HSPB1_S78 and HSPB1_S82\n", + "looking for paths in the network with length: 7 for node HSPB1_S78 and HSPB1_S82\n", + "looking for paths in the network with length: 8 for node HSPB1_S78 and HSPB1_S82\n", + "looking for paths in the network with length: 9 for node HSPB1_S78 and HSPB1_S82\n", + "looking for paths in the network with length: 10 for node HSPB1_S78 and HSPB1_S82\n", + "i_search = 4\n", + "Looking for paths with length: 0 for node HSPB1_S78 and HSPB1_S82\n", + "i_search = 4\n", + "Looking for paths with length: 1 for node HSPB1_S78 and HSPB1_S82\n", + "i_search = 4\n", + "Looking for paths with length: 2 for node HSPB1_S78 and HSPB1_S82\n", + "i_search = 4\n", + "Looking for paths with length: 3 for node HSPB1_S78 and HSPB1_S82\n", + "i_search = 4\n", + "Looking for paths with length: 4 for node HSPB1_S78 and HSPB1_S82\n", + "looking for paths in the network with length: 0 for node HSPB1_S78 and MAPK14_T180\n", + "looking for paths in the network with length: 1 for node HSPB1_S78 and MAPK14_T180\n", + "looking for paths in the network with length: 2 for node HSPB1_S78 and MAPK14_T180\n", + "looking for paths in the network with length: 3 for node HSPB1_S78 and MAPK14_T180\n", + "looking for paths in the network with length: 4 for node HSPB1_S78 and MAPK14_T180\n", + "looking for paths in the network with length: 5 for node HSPB1_S78 and MAPK14_T180\n", + "looking for paths in the network with length: 6 for node HSPB1_S78 and MAPK14_T180\n", + "looking for paths in the network with length: 7 for node HSPB1_S78 and MAPK14_T180\n", + "looking for paths in the network with length: 8 for node HSPB1_S78 and MAPK14_T180\n", + "looking for paths in the network with length: 9 for node HSPB1_S78 and MAPK14_T180\n", + "looking for paths in the network with length: 10 for node HSPB1_S78 and MAPK14_T180\n", + "i_search = 4\n", + "Looking for paths with length: 0 for node HSPB1_S78 and MAPK14_T180\n", + "i_search = 4\n", + "Looking for paths with length: 1 for node HSPB1_S78 and MAPK14_T180\n", + "i_search = 4\n", + "Looking for paths with length: 2 for node HSPB1_S78 and MAPK14_T180\n", + "i_search = 4\n", + "Looking for paths with length: 3 for node HSPB1_S78 and MAPK14_T180\n", + "i_search = 4\n", + "Looking for paths with length: 4 for node HSPB1_S78 and MAPK14_T180\n", + "[['HSPB1_S78', 'MAPKAPK2', 'MAPKAPK2_T334', 'MAPK14', 'MAPK14_T180'], ['HSPB1_S78', 'MAPKAPK2', 'MAPKAPK2_S272', 'MAPK14', 'MAPK14_T180'], ['HSPB1_S78', 'MAPKAPK2', 'MAPKAPK2_T222', 'MAPK14', 'MAPK14_T180']]\n", + "MAPKAPK2 HSPB1_S78\n", + "MAPKAPK2_T334 MAPKAPK2\n", + "MAPK14 MAPKAPK2_T334\n", + "MAPK14_T180 MAPK14\n", + "MAPKAPK2 HSPB1_S78\n", + "MAPKAPK2_S272 MAPKAPK2\n", + "MAPK14 MAPKAPK2_S272\n", + "MAPK14_T180 MAPK14\n", + "MAPKAPK2 HSPB1_S78\n", + "MAPKAPK2_T222 MAPKAPK2\n", + "MAPK14 MAPKAPK2_T222\n", + "MAPK14_T180 MAPK14\n", + "looking for paths in the network with length: 0 for node HSPB1_S78 and MAPK14_Y182\n", + "looking for paths in the network with length: 1 for node HSPB1_S78 and MAPK14_Y182\n", + "looking for paths in the network with length: 2 for node HSPB1_S78 and MAPK14_Y182\n", + "looking for paths in the network with length: 3 for node HSPB1_S78 and MAPK14_Y182\n", + "looking for paths in the network with length: 4 for node HSPB1_S78 and MAPK14_Y182\n", + "Found a path!\n", + "[['HSPB1_S78', 'MAPKAPK2', 'MAPKAPK2_T334', 'MAPK14', 'MAPK14_Y182'], ['HSPB1_S78', 'MAPKAPK2', 'MAPKAPK2_S272', 'MAPK14', 'MAPK14_Y182'], ['HSPB1_S78', 'MAPKAPK2', 'MAPKAPK2_T222', 'MAPK14', 'MAPK14_Y182']]\n", + "looking for paths in the network with length: 0 for node HSPB1_S78 and MAP2K1_S218\n", + "looking for paths in the network with length: 1 for node HSPB1_S78 and MAP2K1_S218\n", + "looking for paths in the network with length: 2 for node HSPB1_S78 and MAP2K1_S218\n", + "looking for paths in the network with length: 3 for node HSPB1_S78 and MAP2K1_S218\n", + "looking for paths in the network with length: 4 for node HSPB1_S78 and MAP2K1_S218\n", + "looking for paths in the network with length: 5 for node HSPB1_S78 and MAP2K1_S218\n", + "looking for paths in the network with length: 6 for node HSPB1_S78 and MAP2K1_S218\n", + "looking for paths in the network with length: 7 for node HSPB1_S78 and MAP2K1_S218\n", + "looking for paths in the network with length: 8 for node HSPB1_S78 and MAP2K1_S218\n", + "looking for paths in the network with length: 9 for node HSPB1_S78 and MAP2K1_S218\n", + "looking for paths in the network with length: 10 for node HSPB1_S78 and MAP2K1_S218\n", + "i_search = 4\n", + "Looking for paths with length: 0 for node HSPB1_S78 and MAP2K1_S218\n", + "i_search = 4\n", + "Looking for paths with length: 1 for node HSPB1_S78 and MAP2K1_S218\n", + "i_search = 4\n", + "Looking for paths with length: 2 for node HSPB1_S78 and MAP2K1_S218\n", + "i_search = 4\n", + "Looking for paths with length: 3 for node HSPB1_S78 and MAP2K1_S218\n", + "i_search = 4\n", + "Looking for paths with length: 4 for node HSPB1_S78 and MAP2K1_S218\n", + "looking for paths in the network with length: 0 for node HSPB1_S78 and MAP2K1_S222\n", + "looking for paths in the network with length: 1 for node HSPB1_S78 and MAP2K1_S222\n", + "looking for paths in the network with length: 2 for node HSPB1_S78 and MAP2K1_S222\n", + "looking for paths in the network with length: 3 for node HSPB1_S78 and MAP2K1_S222\n", + "looking for paths in the network with length: 4 for node HSPB1_S78 and MAP2K1_S222\n", + "looking for paths in the network with length: 5 for node HSPB1_S78 and MAP2K1_S222\n", + "looking for paths in the network with length: 6 for node HSPB1_S78 and MAP2K1_S222\n", + "looking for paths in the network with length: 7 for node HSPB1_S78 and MAP2K1_S222\n", + "looking for paths in the network with length: 8 for node HSPB1_S78 and MAP2K1_S222\n", + "looking for paths in the network with length: 9 for node HSPB1_S78 and MAP2K1_S222\n", + "looking for paths in the network with length: 10 for node HSPB1_S78 and MAP2K1_S222\n", + "i_search = 4\n", + "Looking for paths with length: 0 for node HSPB1_S78 and MAP2K1_S222\n", + "i_search = 4\n", + "Looking for paths with length: 1 for node HSPB1_S78 and MAP2K1_S222\n", + "i_search = 4\n", + "Looking for paths with length: 2 for node HSPB1_S78 and MAP2K1_S222\n", + "i_search = 4\n", + "Looking for paths with length: 3 for node HSPB1_S78 and MAP2K1_S222\n", + "i_search = 4\n", + "Looking for paths with length: 4 for node HSPB1_S78 and MAP2K1_S222\n", + "looking for paths in the network with length: 0 for node HSPB1_S78 and RPS6KA1_S380\n", + "looking for paths in the network with length: 1 for node HSPB1_S78 and RPS6KA1_S380\n", + "looking for paths in the network with length: 2 for node HSPB1_S78 and RPS6KA1_S380\n", + "looking for paths in the network with length: 3 for node HSPB1_S78 and RPS6KA1_S380\n", + "looking for paths in the network with length: 4 for node HSPB1_S78 and RPS6KA1_S380\n", + "looking for paths in the network with length: 5 for node HSPB1_S78 and RPS6KA1_S380\n", + "looking for paths in the network with length: 6 for node HSPB1_S78 and RPS6KA1_S380\n", + "looking for paths in the network with length: 7 for node HSPB1_S78 and RPS6KA1_S380\n", + "looking for paths in the network with length: 8 for node HSPB1_S78 and RPS6KA1_S380\n", + "looking for paths in the network with length: 9 for node HSPB1_S78 and RPS6KA1_S380\n", + "looking for paths in the network with length: 10 for node HSPB1_S78 and RPS6KA1_S380\n", + "i_search = 4\n", + "Looking for paths with length: 0 for node HSPB1_S78 and RPS6KA1_S380\n", + "i_search = 4\n", + "Looking for paths with length: 1 for node HSPB1_S78 and RPS6KA1_S380\n", + "i_search = 4\n", + "Looking for paths with length: 2 for node HSPB1_S78 and RPS6KA1_S380\n", + "i_search = 4\n", + "Looking for paths with length: 3 for node HSPB1_S78 and RPS6KA1_S380\n", + "i_search = 4\n", + "Looking for paths with length: 4 for node HSPB1_S78 and RPS6KA1_S380\n", + "looking for paths in the network with length: 0 for node HSPB1_S78 and CREB1_S133\n", + "looking for paths in the network with length: 1 for node HSPB1_S78 and CREB1_S133\n", + "looking for paths in the network with length: 2 for node HSPB1_S78 and CREB1_S133\n", + "looking for paths in the network with length: 3 for node HSPB1_S78 and CREB1_S133\n", + "looking for paths in the network with length: 4 for node HSPB1_S78 and CREB1_S133\n", + "looking for paths in the network with length: 5 for node HSPB1_S78 and CREB1_S133\n", + "looking for paths in the network with length: 6 for node HSPB1_S78 and CREB1_S133\n", + "looking for paths in the network with length: 7 for node HSPB1_S78 and CREB1_S133\n", + "looking for paths in the network with length: 8 for node HSPB1_S78 and CREB1_S133\n", + "looking for paths in the network with length: 9 for node HSPB1_S78 and CREB1_S133\n", + "looking for paths in the network with length: 10 for node HSPB1_S78 and CREB1_S133\n", + "i_search = 4\n", + "Looking for paths with length: 0 for node HSPB1_S78 and CREB1_S133\n", + "i_search = 4\n", + "Looking for paths with length: 1 for node HSPB1_S78 and CREB1_S133\n", + "i_search = 4\n", + "Looking for paths with length: 2 for node HSPB1_S78 and CREB1_S133\n", + "i_search = 4\n", + "Looking for paths with length: 3 for node HSPB1_S78 and CREB1_S133\n", + "i_search = 4\n", + "Looking for paths with length: 4 for node HSPB1_S78 and CREB1_S133\n", + "looking for paths in the network with length: 0 for node HSPB1_S78 and NFKBIA_S32\n", + "looking for paths in the network with length: 1 for node HSPB1_S78 and NFKBIA_S32\n", + "looking for paths in the network with length: 2 for node HSPB1_S78 and NFKBIA_S32\n", + "looking for paths in the network with length: 3 for node HSPB1_S78 and NFKBIA_S32\n", + "looking for paths in the network with length: 4 for node HSPB1_S78 and NFKBIA_S32\n", + "looking for paths in the network with length: 5 for node HSPB1_S78 and NFKBIA_S32\n", + "looking for paths in the network with length: 6 for node HSPB1_S78 and NFKBIA_S32\n", + "looking for paths in the network with length: 7 for node HSPB1_S78 and NFKBIA_S32\n", + "looking for paths in the network with length: 8 for node HSPB1_S78 and NFKBIA_S32\n", + "looking for paths in the network with length: 9 for node HSPB1_S78 and NFKBIA_S32\n", + "looking for paths in the network with length: 10 for node HSPB1_S78 and NFKBIA_S32\n", + "i_search = 4\n", + "Looking for paths with length: 0 for node HSPB1_S78 and NFKBIA_S32\n", + "i_search = 4\n", + "Looking for paths with length: 1 for node HSPB1_S78 and NFKBIA_S32\n", + "i_search = 4\n", + "Looking for paths with length: 2 for node HSPB1_S78 and NFKBIA_S32\n", + "i_search = 4\n", + "Looking for paths with length: 3 for node HSPB1_S78 and NFKBIA_S32\n", + "i_search = 4\n", + "Looking for paths with length: 4 for node HSPB1_S78 and NFKBIA_S32\n", + "looking for paths in the network with length: 0 for node HSPB1_S78 and NFKBIA_S36\n", + "looking for paths in the network with length: 1 for node HSPB1_S78 and NFKBIA_S36\n", + "looking for paths in the network with length: 2 for node HSPB1_S78 and NFKBIA_S36\n", + "looking for paths in the network with length: 3 for node HSPB1_S78 and NFKBIA_S36\n", + "looking for paths in the network with length: 4 for node HSPB1_S78 and NFKBIA_S36\n", + "looking for paths in the network with length: 5 for node HSPB1_S78 and NFKBIA_S36\n", + "looking for paths in the network with length: 6 for node HSPB1_S78 and NFKBIA_S36\n", + "looking for paths in the network with length: 7 for node HSPB1_S78 and NFKBIA_S36\n", + "looking for paths in the network with length: 8 for node HSPB1_S78 and NFKBIA_S36\n", + "looking for paths in the network with length: 9 for node HSPB1_S78 and NFKBIA_S36\n", + "looking for paths in the network with length: 10 for node HSPB1_S78 and NFKBIA_S36\n", + "i_search = 4\n", + "Looking for paths with length: 0 for node HSPB1_S78 and NFKBIA_S36\n", + "i_search = 4\n", + "Looking for paths with length: 1 for node HSPB1_S78 and NFKBIA_S36\n", + "i_search = 4\n", + "Looking for paths with length: 2 for node HSPB1_S78 and NFKBIA_S36\n", + "i_search = 4\n", + "Looking for paths with length: 3 for node HSPB1_S78 and NFKBIA_S36\n", + "i_search = 4\n", + "Looking for paths with length: 4 for node HSPB1_S78 and NFKBIA_S36\n", + "looking for paths in the network with length: 0 for node HSPB1_S78 and MTOR_S2448\n", + "looking for paths in the network with length: 1 for node HSPB1_S78 and MTOR_S2448\n", + "looking for paths in the network with length: 2 for node HSPB1_S78 and MTOR_S2448\n", + "looking for paths in the network with length: 3 for node HSPB1_S78 and MTOR_S2448\n", + "looking for paths in the network with length: 4 for node HSPB1_S78 and MTOR_S2448\n", + "looking for paths in the network with length: 5 for node HSPB1_S78 and MTOR_S2448\n", + "looking for paths in the network with length: 6 for node HSPB1_S78 and MTOR_S2448\n", + "looking for paths in the network with length: 7 for node HSPB1_S78 and MTOR_S2448\n", + "looking for paths in the network with length: 8 for node HSPB1_S78 and MTOR_S2448\n", + "looking for paths in the network with length: 9 for node HSPB1_S78 and MTOR_S2448\n", + "looking for paths in the network with length: 10 for node HSPB1_S78 and MTOR_S2448\n", + "i_search = 4\n", + "Looking for paths with length: 0 for node HSPB1_S78 and MTOR_S2448\n", + "i_search = 4\n", + "Looking for paths with length: 1 for node HSPB1_S78 and MTOR_S2448\n", + "i_search = 4\n", + "Looking for paths with length: 2 for node HSPB1_S78 and MTOR_S2448\n", + "i_search = 4\n", + "Looking for paths with length: 3 for node HSPB1_S78 and MTOR_S2448\n", + "i_search = 4\n", + "Looking for paths with length: 4 for node HSPB1_S78 and MTOR_S2448\n", + "looking for paths in the network with length: 0 for node HSPB1_S78 and JUN_S63\n", + "looking for paths in the network with length: 1 for node HSPB1_S78 and JUN_S63\n", + "looking for paths in the network with length: 2 for node HSPB1_S78 and JUN_S63\n", + "looking for paths in the network with length: 3 for node HSPB1_S78 and JUN_S63\n", + "looking for paths in the network with length: 4 for node HSPB1_S78 and JUN_S63\n", + "looking for paths in the network with length: 5 for node HSPB1_S78 and JUN_S63\n", + "looking for paths in the network with length: 6 for node HSPB1_S78 and JUN_S63\n", + "looking for paths in the network with length: 7 for node HSPB1_S78 and JUN_S63\n", + "looking for paths in the network with length: 8 for node HSPB1_S78 and JUN_S63\n", + "looking for paths in the network with length: 9 for node HSPB1_S78 and JUN_S63\n", + "looking for paths in the network with length: 10 for node HSPB1_S78 and JUN_S63\n", + "i_search = 4\n", + "Looking for paths with length: 0 for node HSPB1_S78 and JUN_S63\n", + "i_search = 4\n", + "Looking for paths with length: 1 for node HSPB1_S78 and JUN_S63\n", + "i_search = 4\n", + "Looking for paths with length: 2 for node HSPB1_S78 and JUN_S63\n", + "i_search = 4\n", + "Looking for paths with length: 3 for node HSPB1_S78 and JUN_S63\n", + "i_search = 4\n", + "Looking for paths with length: 4 for node HSPB1_S78 and JUN_S63\n", + "looking for paths in the network with length: 0 for node HSPB1_S78 and EGFR_Y1068\n", + "looking for paths in the network with length: 1 for node HSPB1_S78 and EGFR_Y1068\n", + "looking for paths in the network with length: 2 for node HSPB1_S78 and EGFR_Y1068\n", + "looking for paths in the network with length: 3 for node HSPB1_S78 and EGFR_Y1068\n", + "looking for paths in the network with length: 4 for node HSPB1_S78 and EGFR_Y1068\n", + "looking for paths in the network with length: 5 for node HSPB1_S78 and EGFR_Y1068\n", + "looking for paths in the network with length: 6 for node HSPB1_S78 and EGFR_Y1068\n", + "looking for paths in the network with length: 7 for node HSPB1_S78 and EGFR_Y1068\n", + "looking for paths in the network with length: 8 for node HSPB1_S78 and EGFR_Y1068\n", + "looking for paths in the network with length: 9 for node HSPB1_S78 and EGFR_Y1068\n", + "looking for paths in the network with length: 10 for node HSPB1_S78 and EGFR_Y1068\n", + "i_search = 4\n", + "Looking for paths with length: 0 for node HSPB1_S78 and EGFR_Y1068\n", + "i_search = 4\n", + "Looking for paths with length: 1 for node HSPB1_S78 and EGFR_Y1068\n", + "i_search = 4\n", + "Looking for paths with length: 2 for node HSPB1_S78 and EGFR_Y1068\n", + "i_search = 4\n", + "Looking for paths with length: 3 for node HSPB1_S78 and EGFR_Y1068\n", + "i_search = 4\n", + "Looking for paths with length: 4 for node HSPB1_S78 and EGFR_Y1068\n", + "looking for paths in the network with length: 0 for node HSPB1_S78 and MAPK3_T202\n", + "looking for paths in the network with length: 1 for node HSPB1_S78 and MAPK3_T202\n", + "looking for paths in the network with length: 2 for node HSPB1_S78 and MAPK3_T202\n", + "looking for paths in the network with length: 3 for node HSPB1_S78 and MAPK3_T202\n", + "looking for paths in the network with length: 4 for node HSPB1_S78 and MAPK3_T202\n", + "looking for paths in the network with length: 5 for node HSPB1_S78 and MAPK3_T202\n", + "looking for paths in the network with length: 6 for node HSPB1_S78 and MAPK3_T202\n", + "looking for paths in the network with length: 7 for node HSPB1_S78 and MAPK3_T202\n", + "looking for paths in the network with length: 8 for node HSPB1_S78 and MAPK3_T202\n", + "looking for paths in the network with length: 9 for node HSPB1_S78 and MAPK3_T202\n", + "looking for paths in the network with length: 10 for node HSPB1_S78 and MAPK3_T202\n", + "i_search = 4\n", + "Looking for paths with length: 0 for node HSPB1_S78 and MAPK3_T202\n", + "i_search = 4\n", + "Looking for paths with length: 1 for node HSPB1_S78 and MAPK3_T202\n", + "i_search = 4\n", + "Looking for paths with length: 2 for node HSPB1_S78 and MAPK3_T202\n", + "i_search = 4\n", + "Looking for paths with length: 3 for node HSPB1_S78 and MAPK3_T202\n", + "i_search = 4\n", + "Looking for paths with length: 4 for node HSPB1_S78 and MAPK3_T202\n", + "looking for paths in the network with length: 0 for node HSPB1_S78 and MAPK3_Y204\n", + "looking for paths in the network with length: 1 for node HSPB1_S78 and MAPK3_Y204\n", + "looking for paths in the network with length: 2 for node HSPB1_S78 and MAPK3_Y204\n", + "looking for paths in the network with length: 3 for node HSPB1_S78 and MAPK3_Y204\n", + "looking for paths in the network with length: 4 for node HSPB1_S78 and MAPK3_Y204\n", + "looking for paths in the network with length: 5 for node HSPB1_S78 and MAPK3_Y204\n", + "looking for paths in the network with length: 6 for node HSPB1_S78 and MAPK3_Y204\n", + "looking for paths in the network with length: 7 for node HSPB1_S78 and MAPK3_Y204\n", + "looking for paths in the network with length: 8 for node HSPB1_S78 and MAPK3_Y204\n", + "looking for paths in the network with length: 9 for node HSPB1_S78 and MAPK3_Y204\n", + "looking for paths in the network with length: 10 for node HSPB1_S78 and MAPK3_Y204\n", + "i_search = 4\n", + "Looking for paths with length: 0 for node HSPB1_S78 and MAPK3_Y204\n", + "i_search = 4\n", + "Looking for paths with length: 1 for node HSPB1_S78 and MAPK3_Y204\n", + "i_search = 4\n", + "Looking for paths with length: 2 for node HSPB1_S78 and MAPK3_Y204\n", + "i_search = 4\n", + "Looking for paths with length: 3 for node HSPB1_S78 and MAPK3_Y204\n", + "i_search = 4\n", + "Looking for paths with length: 4 for node HSPB1_S78 and MAPK3_Y204\n", + "looking for paths in the network with length: 0 for node HSPB1_S78 and PTPN11_Y542\n", + "looking for paths in the network with length: 1 for node HSPB1_S78 and PTPN11_Y542\n", + "looking for paths in the network with length: 2 for node HSPB1_S78 and PTPN11_Y542\n", + "looking for paths in the network with length: 3 for node HSPB1_S78 and PTPN11_Y542\n", + "looking for paths in the network with length: 4 for node HSPB1_S78 and PTPN11_Y542\n", + "looking for paths in the network with length: 5 for node HSPB1_S78 and PTPN11_Y542\n", + "looking for paths in the network with length: 6 for node HSPB1_S78 and PTPN11_Y542\n", + "looking for paths in the network with length: 7 for node HSPB1_S78 and PTPN11_Y542\n", + "looking for paths in the network with length: 8 for node HSPB1_S78 and PTPN11_Y542\n", + "looking for paths in the network with length: 9 for node HSPB1_S78 and PTPN11_Y542\n", + "looking for paths in the network with length: 10 for node HSPB1_S78 and PTPN11_Y542\n", + "i_search = 4\n", + "Looking for paths with length: 0 for node HSPB1_S78 and PTPN11_Y542\n", + "i_search = 4\n", + "Looking for paths with length: 1 for node HSPB1_S78 and PTPN11_Y542\n", + "i_search = 4\n", + "Looking for paths with length: 2 for node HSPB1_S78 and PTPN11_Y542\n", + "i_search = 4\n", + "Looking for paths with length: 3 for node HSPB1_S78 and PTPN11_Y542\n", + "i_search = 4\n", + "Looking for paths with length: 4 for node HSPB1_S78 and PTPN11_Y542\n", + "looking for paths in the network with length: 0 for node HSPB1_S78 and STAT3_Y705\n", + "looking for paths in the network with length: 1 for node HSPB1_S78 and STAT3_Y705\n", + "looking for paths in the network with length: 2 for node HSPB1_S78 and STAT3_Y705\n", + "looking for paths in the network with length: 3 for node HSPB1_S78 and STAT3_Y705\n", + "looking for paths in the network with length: 4 for node HSPB1_S78 and STAT3_Y705\n", + "looking for paths in the network with length: 5 for node HSPB1_S78 and STAT3_Y705\n", + "looking for paths in the network with length: 6 for node HSPB1_S78 and STAT3_Y705\n", + "looking for paths in the network with length: 7 for node HSPB1_S78 and STAT3_Y705\n", + "looking for paths in the network with length: 8 for node HSPB1_S78 and STAT3_Y705\n", + "looking for paths in the network with length: 9 for node HSPB1_S78 and STAT3_Y705\n", + "looking for paths in the network with length: 10 for node HSPB1_S78 and STAT3_Y705\n", + "i_search = 4\n", + "Looking for paths with length: 0 for node HSPB1_S78 and STAT3_Y705\n", + "i_search = 4\n", + "Looking for paths with length: 1 for node HSPB1_S78 and STAT3_Y705\n", + "i_search = 4\n", + "Looking for paths with length: 2 for node HSPB1_S78 and STAT3_Y705\n", + "i_search = 4\n", + "Looking for paths with length: 3 for node HSPB1_S78 and STAT3_Y705\n", + "i_search = 4\n", + "Looking for paths with length: 4 for node HSPB1_S78 and STAT3_Y705\n", + "looking for paths in the network with length: 0 for node HSPB1_S78 and CHEK2_T68\n", + "looking for paths in the network with length: 1 for node HSPB1_S78 and CHEK2_T68\n", + "looking for paths in the network with length: 2 for node HSPB1_S78 and CHEK2_T68\n", + "looking for paths in the network with length: 3 for node HSPB1_S78 and CHEK2_T68\n", + "looking for paths in the network with length: 4 for node HSPB1_S78 and CHEK2_T68\n", + "looking for paths in the network with length: 5 for node HSPB1_S78 and CHEK2_T68\n", + "looking for paths in the network with length: 6 for node HSPB1_S78 and CHEK2_T68\n", + "looking for paths in the network with length: 7 for node HSPB1_S78 and CHEK2_T68\n", + "looking for paths in the network with length: 8 for node HSPB1_S78 and CHEK2_T68\n", + "looking for paths in the network with length: 9 for node HSPB1_S78 and CHEK2_T68\n", + "looking for paths in the network with length: 10 for node HSPB1_S78 and CHEK2_T68\n", + "i_search = 4\n", + "Looking for paths with length: 0 for node HSPB1_S78 and CHEK2_T68\n", + "i_search = 4\n", + "Looking for paths with length: 1 for node HSPB1_S78 and CHEK2_T68\n", + "i_search = 4\n", + "Looking for paths with length: 2 for node HSPB1_S78 and CHEK2_T68\n", + "i_search = 4\n", + "Looking for paths with length: 3 for node HSPB1_S78 and CHEK2_T68\n", + "i_search = 4\n", + "Looking for paths with length: 4 for node HSPB1_S78 and CHEK2_T68\n", + "looking for paths in the network with length: 0 for node HSPB1_S78 and RELA_S536\n", + "looking for paths in the network with length: 1 for node HSPB1_S78 and RELA_S536\n", + "looking for paths in the network with length: 2 for node HSPB1_S78 and RELA_S536\n", + "looking for paths in the network with length: 3 for node HSPB1_S78 and RELA_S536\n", + "looking for paths in the network with length: 4 for node HSPB1_S78 and RELA_S536\n", + "looking for paths in the network with length: 5 for node HSPB1_S78 and RELA_S536\n", + "looking for paths in the network with length: 6 for node HSPB1_S78 and RELA_S536\n", + "looking for paths in the network with length: 7 for node HSPB1_S78 and RELA_S536\n", + "looking for paths in the network with length: 8 for node HSPB1_S78 and RELA_S536\n", + "looking for paths in the network with length: 9 for node HSPB1_S78 and RELA_S536\n", + "looking for paths in the network with length: 10 for node HSPB1_S78 and RELA_S536\n", + "i_search = 4\n", + "Looking for paths with length: 0 for node HSPB1_S78 and RELA_S536\n", + "i_search = 4\n", + "Looking for paths with length: 1 for node HSPB1_S78 and RELA_S536\n", + "i_search = 4\n", + "Looking for paths with length: 2 for node HSPB1_S78 and RELA_S536\n", + "i_search = 4\n", + "Looking for paths with length: 3 for node HSPB1_S78 and RELA_S536\n", + "i_search = 4\n", + "Looking for paths with length: 4 for node HSPB1_S78 and RELA_S536\n", + "looking for paths in the network with length: 0 for node HSPB1_S78 and MARCKS_S170\n", + "looking for paths in the network with length: 1 for node HSPB1_S78 and MARCKS_S170\n", + "looking for paths in the network with length: 2 for node HSPB1_S78 and MARCKS_S170\n", + "looking for paths in the network with length: 3 for node HSPB1_S78 and MARCKS_S170\n", + "looking for paths in the network with length: 4 for node HSPB1_S78 and MARCKS_S170\n", + "looking for paths in the network with length: 5 for node HSPB1_S78 and MARCKS_S170\n", + "looking for paths in the network with length: 6 for node HSPB1_S78 and MARCKS_S170\n", + "looking for paths in the network with length: 7 for node HSPB1_S78 and MARCKS_S170\n", + "looking for paths in the network with length: 8 for node HSPB1_S78 and MARCKS_S170\n", + "looking for paths in the network with length: 9 for node HSPB1_S78 and MARCKS_S170\n", + "looking for paths in the network with length: 10 for node HSPB1_S78 and MARCKS_S170\n", + "i_search = 4\n", + "Looking for paths with length: 0 for node HSPB1_S78 and MARCKS_S170\n", + "i_search = 4\n", + "Looking for paths with length: 1 for node HSPB1_S78 and MARCKS_S170\n", + "i_search = 4\n", + "Looking for paths with length: 2 for node HSPB1_S78 and MARCKS_S170\n", + "i_search = 4\n", + "Looking for paths with length: 3 for node HSPB1_S78 and MARCKS_S170\n", + "i_search = 4\n", + "Looking for paths with length: 4 for node HSPB1_S78 and MARCKS_S170\n", + "looking for paths in the network with length: 0 for node HSPB1_S78 and SMAD3\n", + "looking for paths in the network with length: 1 for node HSPB1_S78 and SMAD3\n", + "looking for paths in the network with length: 2 for node HSPB1_S78 and SMAD3\n", + "looking for paths in the network with length: 3 for node HSPB1_S78 and SMAD3\n", + "looking for paths in the network with length: 4 for node HSPB1_S78 and SMAD3\n", + "looking for paths in the network with length: 5 for node HSPB1_S78 and SMAD3\n", + "looking for paths in the network with length: 6 for node HSPB1_S78 and SMAD3\n", + "looking for paths in the network with length: 7 for node HSPB1_S78 and SMAD3\n", + "looking for paths in the network with length: 8 for node HSPB1_S78 and SMAD3\n", + "looking for paths in the network with length: 9 for node HSPB1_S78 and SMAD3\n", + "looking for paths in the network with length: 10 for node HSPB1_S78 and SMAD3\n", + "i_search = 4\n", + "Looking for paths with length: 0 for node HSPB1_S78 and SMAD3\n", + "i_search = 4\n", + "Looking for paths with length: 1 for node HSPB1_S78 and SMAD3\n", + "i_search = 4\n", + "Looking for paths with length: 2 for node HSPB1_S78 and SMAD3\n", + "i_search = 4\n", + "Looking for paths with length: 3 for node HSPB1_S78 and SMAD3\n", + "i_search = 4\n", + "Looking for paths with length: 4 for node HSPB1_S78 and SMAD3\n", + "looking for paths in the network with length: 0 for node HSPB1_S78 and TP53\n", + "looking for paths in the network with length: 1 for node HSPB1_S78 and TP53\n", + "looking for paths in the network with length: 2 for node HSPB1_S78 and TP53\n", + "looking for paths in the network with length: 3 for node HSPB1_S78 and TP53\n", + "looking for paths in the network with length: 4 for node HSPB1_S78 and TP53\n", + "looking for paths in the network with length: 5 for node HSPB1_S78 and TP53\n", + "looking for paths in the network with length: 6 for node HSPB1_S78 and TP53\n", + "looking for paths in the network with length: 7 for node HSPB1_S78 and TP53\n", + "looking for paths in the network with length: 8 for node HSPB1_S78 and TP53\n", + "looking for paths in the network with length: 9 for node HSPB1_S78 and TP53\n", + "looking for paths in the network with length: 10 for node HSPB1_S78 and TP53\n", + "i_search = 4\n", + "Looking for paths with length: 0 for node HSPB1_S78 and TP53\n", + "i_search = 4\n", + "Looking for paths with length: 1 for node HSPB1_S78 and TP53\n", + "i_search = 4\n", + "Looking for paths with length: 2 for node HSPB1_S78 and TP53\n", + "i_search = 4\n", + "Looking for paths with length: 3 for node HSPB1_S78 and TP53\n", + "i_search = 4\n", + "Looking for paths with length: 4 for node HSPB1_S78 and TP53\n", + "looking for paths in the network with length: 0 for node HSPB1_S78 and AKT1S1\n", + "looking for paths in the network with length: 1 for node HSPB1_S78 and AKT1S1\n", + "looking for paths in the network with length: 2 for node HSPB1_S78 and AKT1S1\n", + "looking for paths in the network with length: 3 for node HSPB1_S78 and AKT1S1\n", + "looking for paths in the network with length: 4 for node HSPB1_S78 and AKT1S1\n", + "looking for paths in the network with length: 5 for node HSPB1_S78 and AKT1S1\n", + "looking for paths in the network with length: 6 for node HSPB1_S78 and AKT1S1\n", + "looking for paths in the network with length: 7 for node HSPB1_S78 and AKT1S1\n", + "looking for paths in the network with length: 8 for node HSPB1_S78 and AKT1S1\n", + "looking for paths in the network with length: 9 for node HSPB1_S78 and AKT1S1\n", + "looking for paths in the network with length: 10 for node HSPB1_S78 and AKT1S1\n", + "i_search = 4\n", + "Looking for paths with length: 0 for node HSPB1_S78 and AKT1S1\n", + "i_search = 4\n", + "Looking for paths with length: 1 for node HSPB1_S78 and AKT1S1\n", + "i_search = 4\n", + "Looking for paths with length: 2 for node HSPB1_S78 and AKT1S1\n", + "i_search = 4\n", + "Looking for paths with length: 3 for node HSPB1_S78 and AKT1S1\n", + "i_search = 4\n", + "Looking for paths with length: 4 for node HSPB1_S78 and AKT1S1\n", + "looking for paths in the network with length: 0 for node HSPB1_S78 and GSK3B\n", + "looking for paths in the network with length: 1 for node HSPB1_S78 and GSK3B\n", + "looking for paths in the network with length: 2 for node HSPB1_S78 and GSK3B\n", + "looking for paths in the network with length: 3 for node HSPB1_S78 and GSK3B\n", + "looking for paths in the network with length: 4 for node HSPB1_S78 and GSK3B\n", + "looking for paths in the network with length: 5 for node HSPB1_S78 and GSK3B\n", + "looking for paths in the network with length: 6 for node HSPB1_S78 and GSK3B\n", + "looking for paths in the network with length: 7 for node HSPB1_S78 and GSK3B\n", + "looking for paths in the network with length: 8 for node HSPB1_S78 and GSK3B\n", + "looking for paths in the network with length: 9 for node HSPB1_S78 and GSK3B\n", + "looking for paths in the network with length: 10 for node HSPB1_S78 and GSK3B\n", + "i_search = 4\n", + "Looking for paths with length: 0 for node HSPB1_S78 and GSK3B\n", + "i_search = 4\n", + "Looking for paths with length: 1 for node HSPB1_S78 and GSK3B\n", + "i_search = 4\n", + "Looking for paths with length: 2 for node HSPB1_S78 and GSK3B\n", + "i_search = 4\n", + "Looking for paths with length: 3 for node HSPB1_S78 and GSK3B\n", + "i_search = 4\n", + "Looking for paths with length: 4 for node HSPB1_S78 and GSK3B\n", + "looking for paths in the network with length: 0 for node HSPB1_S78 and AKT1\n", + "looking for paths in the network with length: 1 for node HSPB1_S78 and AKT1\n", + "looking for paths in the network with length: 2 for node HSPB1_S78 and AKT1\n", + "looking for paths in the network with length: 3 for node HSPB1_S78 and AKT1\n", + "looking for paths in the network with length: 4 for node HSPB1_S78 and AKT1\n", + "looking for paths in the network with length: 5 for node HSPB1_S78 and AKT1\n", + "looking for paths in the network with length: 6 for node HSPB1_S78 and AKT1\n", + "looking for paths in the network with length: 7 for node HSPB1_S78 and AKT1\n", + "looking for paths in the network with length: 8 for node HSPB1_S78 and AKT1\n", + "looking for paths in the network with length: 9 for node HSPB1_S78 and AKT1\n", + "looking for paths in the network with length: 10 for node HSPB1_S78 and AKT1\n", + "i_search = 4\n", + "Looking for paths with length: 0 for node HSPB1_S78 and AKT1\n", + "i_search = 4\n", + "Looking for paths with length: 1 for node HSPB1_S78 and AKT1\n", + "i_search = 4\n", + "Looking for paths with length: 2 for node HSPB1_S78 and AKT1\n", + "i_search = 4\n", + "Looking for paths with length: 3 for node HSPB1_S78 and AKT1\n", + "i_search = 4\n", + "Looking for paths with length: 4 for node HSPB1_S78 and AKT1\n", + "looking for paths in the network with length: 0 for node HSPB1_S78 and HSPB1\n", + "looking for paths in the network with length: 1 for node HSPB1_S78 and HSPB1\n", + "looking for paths in the network with length: 2 for node HSPB1_S78 and HSPB1\n", + "looking for paths in the network with length: 3 for node HSPB1_S78 and HSPB1\n", + "looking for paths in the network with length: 4 for node HSPB1_S78 and HSPB1\n", + "looking for paths in the network with length: 5 for node HSPB1_S78 and HSPB1\n", + "looking for paths in the network with length: 6 for node HSPB1_S78 and HSPB1\n", + "looking for paths in the network with length: 7 for node HSPB1_S78 and HSPB1\n", + "looking for paths in the network with length: 8 for node HSPB1_S78 and HSPB1\n", + "looking for paths in the network with length: 9 for node HSPB1_S78 and HSPB1\n", + "looking for paths in the network with length: 10 for node HSPB1_S78 and HSPB1\n", + "i_search = 4\n", + "Looking for paths with length: 0 for node HSPB1_S78 and HSPB1\n", + "i_search = 4\n", + "Looking for paths with length: 1 for node HSPB1_S78 and HSPB1\n", + "i_search = 4\n", + "Looking for paths with length: 2 for node HSPB1_S78 and HSPB1\n", + "i_search = 4\n", + "Looking for paths with length: 3 for node HSPB1_S78 and HSPB1\n", + "i_search = 4\n", + "Looking for paths with length: 4 for node HSPB1_S78 and HSPB1\n", + "looking for paths in the network with length: 0 for node HSPB1_S78 and MAPK14\n", + "looking for paths in the network with length: 1 for node HSPB1_S78 and MAPK14\n", + "looking for paths in the network with length: 2 for node HSPB1_S78 and MAPK14\n", + "looking for paths in the network with length: 3 for node HSPB1_S78 and MAPK14\n", + "looking for paths in the network with length: 4 for node HSPB1_S78 and MAPK14\n", + "looking for paths in the network with length: 5 for node HSPB1_S78 and MAPK14\n", + "looking for paths in the network with length: 6 for node HSPB1_S78 and MAPK14\n", + "looking for paths in the network with length: 7 for node HSPB1_S78 and MAPK14\n", + "looking for paths in the network with length: 8 for node HSPB1_S78 and MAPK14\n", + "looking for paths in the network with length: 9 for node HSPB1_S78 and MAPK14\n", + "looking for paths in the network with length: 10 for node HSPB1_S78 and MAPK14\n", + "i_search = 4\n", + "Looking for paths with length: 0 for node HSPB1_S78 and MAPK14\n", + "i_search = 4\n", + "Looking for paths with length: 1 for node HSPB1_S78 and MAPK14\n", + "i_search = 4\n", + "Looking for paths with length: 2 for node HSPB1_S78 and MAPK14\n", + "i_search = 4\n", + "Looking for paths with length: 3 for node HSPB1_S78 and MAPK14\n", + "i_search = 4\n", + "Looking for paths with length: 4 for node HSPB1_S78 and MAPK14\n", + "looking for paths in the network with length: 0 for node HSPB1_S78 and MAP2K1\n", + "looking for paths in the network with length: 1 for node HSPB1_S78 and MAP2K1\n", + "looking for paths in the network with length: 2 for node HSPB1_S78 and MAP2K1\n", + "looking for paths in the network with length: 3 for node HSPB1_S78 and MAP2K1\n", + "looking for paths in the network with length: 4 for node HSPB1_S78 and MAP2K1\n", + "looking for paths in the network with length: 5 for node HSPB1_S78 and MAP2K1\n", + "looking for paths in the network with length: 6 for node HSPB1_S78 and MAP2K1\n", + "looking for paths in the network with length: 7 for node HSPB1_S78 and MAP2K1\n", + "looking for paths in the network with length: 8 for node HSPB1_S78 and MAP2K1\n", + "looking for paths in the network with length: 9 for node HSPB1_S78 and MAP2K1\n", + "looking for paths in the network with length: 10 for node HSPB1_S78 and MAP2K1\n", + "i_search = 4\n", + "Looking for paths with length: 0 for node HSPB1_S78 and MAP2K1\n", + "i_search = 4\n", + "Looking for paths with length: 1 for node HSPB1_S78 and MAP2K1\n", + "i_search = 4\n", + "Looking for paths with length: 2 for node HSPB1_S78 and MAP2K1\n", + "i_search = 4\n", + "Looking for paths with length: 3 for node HSPB1_S78 and MAP2K1\n", + "i_search = 4\n", + "Looking for paths with length: 4 for node HSPB1_S78 and MAP2K1\n", + "looking for paths in the network with length: 0 for node HSPB1_S78 and RPS6KA1\n", + "looking for paths in the network with length: 1 for node HSPB1_S78 and RPS6KA1\n", + "looking for paths in the network with length: 2 for node HSPB1_S78 and RPS6KA1\n", + "looking for paths in the network with length: 3 for node HSPB1_S78 and RPS6KA1\n", + "looking for paths in the network with length: 4 for node HSPB1_S78 and RPS6KA1\n", + "looking for paths in the network with length: 5 for node HSPB1_S78 and RPS6KA1\n", + "looking for paths in the network with length: 6 for node HSPB1_S78 and RPS6KA1\n", + "looking for paths in the network with length: 7 for node HSPB1_S78 and RPS6KA1\n", + "looking for paths in the network with length: 8 for node HSPB1_S78 and RPS6KA1\n", + "looking for paths in the network with length: 9 for node HSPB1_S78 and RPS6KA1\n", + "looking for paths in the network with length: 10 for node HSPB1_S78 and RPS6KA1\n", + "i_search = 4\n", + "Looking for paths with length: 0 for node HSPB1_S78 and RPS6KA1\n", + "i_search = 4\n", + "Looking for paths with length: 1 for node HSPB1_S78 and RPS6KA1\n", + "i_search = 4\n", + "Looking for paths with length: 2 for node HSPB1_S78 and RPS6KA1\n", + "i_search = 4\n", + "Looking for paths with length: 3 for node HSPB1_S78 and RPS6KA1\n", + "i_search = 4\n", + "Looking for paths with length: 4 for node HSPB1_S78 and RPS6KA1\n", + "looking for paths in the network with length: 0 for node HSPB1_S78 and CREB1\n", + "looking for paths in the network with length: 1 for node HSPB1_S78 and CREB1\n", + "looking for paths in the network with length: 2 for node HSPB1_S78 and CREB1\n", + "looking for paths in the network with length: 3 for node HSPB1_S78 and CREB1\n", + "looking for paths in the network with length: 4 for node HSPB1_S78 and CREB1\n", + "looking for paths in the network with length: 5 for node HSPB1_S78 and CREB1\n", + "looking for paths in the network with length: 6 for node HSPB1_S78 and CREB1\n", + "looking for paths in the network with length: 7 for node HSPB1_S78 and CREB1\n", + "looking for paths in the network with length: 8 for node HSPB1_S78 and CREB1\n", + "looking for paths in the network with length: 9 for node HSPB1_S78 and CREB1\n", + "looking for paths in the network with length: 10 for node HSPB1_S78 and CREB1\n", + "i_search = 4\n", + "Looking for paths with length: 0 for node HSPB1_S78 and CREB1\n", + "i_search = 4\n", + "Looking for paths with length: 1 for node HSPB1_S78 and CREB1\n", + "i_search = 4\n", + "Looking for paths with length: 2 for node HSPB1_S78 and CREB1\n", + "i_search = 4\n", + "Looking for paths with length: 3 for node HSPB1_S78 and CREB1\n", + "i_search = 4\n", + "Looking for paths with length: 4 for node HSPB1_S78 and CREB1\n", + "looking for paths in the network with length: 0 for node HSPB1_S78 and NFKBIA\n", + "looking for paths in the network with length: 1 for node HSPB1_S78 and NFKBIA\n", + "looking for paths in the network with length: 2 for node HSPB1_S78 and NFKBIA\n", + "looking for paths in the network with length: 3 for node HSPB1_S78 and NFKBIA\n", + "looking for paths in the network with length: 4 for node HSPB1_S78 and NFKBIA\n", + "looking for paths in the network with length: 5 for node HSPB1_S78 and NFKBIA\n", + "looking for paths in the network with length: 6 for node HSPB1_S78 and NFKBIA\n", + "looking for paths in the network with length: 7 for node HSPB1_S78 and NFKBIA\n", + "looking for paths in the network with length: 8 for node HSPB1_S78 and NFKBIA\n", + "looking for paths in the network with length: 9 for node HSPB1_S78 and NFKBIA\n", + "looking for paths in the network with length: 10 for node HSPB1_S78 and NFKBIA\n", + "i_search = 4\n", + "Looking for paths with length: 0 for node HSPB1_S78 and NFKBIA\n", + "i_search = 4\n", + "Looking for paths with length: 1 for node HSPB1_S78 and NFKBIA\n", + "i_search = 4\n", + "Looking for paths with length: 2 for node HSPB1_S78 and NFKBIA\n", + "i_search = 4\n", + "Looking for paths with length: 3 for node HSPB1_S78 and NFKBIA\n", + "i_search = 4\n", + "Looking for paths with length: 4 for node HSPB1_S78 and NFKBIA\n", + "looking for paths in the network with length: 0 for node HSPB1_S78 and MTOR\n", + "looking for paths in the network with length: 1 for node HSPB1_S78 and MTOR\n", + "looking for paths in the network with length: 2 for node HSPB1_S78 and MTOR\n", + "looking for paths in the network with length: 3 for node HSPB1_S78 and MTOR\n", + "looking for paths in the network with length: 4 for node HSPB1_S78 and MTOR\n", + "looking for paths in the network with length: 5 for node HSPB1_S78 and MTOR\n", + "looking for paths in the network with length: 6 for node HSPB1_S78 and MTOR\n", + "looking for paths in the network with length: 7 for node HSPB1_S78 and MTOR\n", + "looking for paths in the network with length: 8 for node HSPB1_S78 and MTOR\n", + "looking for paths in the network with length: 9 for node HSPB1_S78 and MTOR\n", + "looking for paths in the network with length: 10 for node HSPB1_S78 and MTOR\n", + "i_search = 4\n", + "Looking for paths with length: 0 for node HSPB1_S78 and MTOR\n", + "i_search = 4\n", + "Looking for paths with length: 1 for node HSPB1_S78 and MTOR\n", + "i_search = 4\n", + "Looking for paths with length: 2 for node HSPB1_S78 and MTOR\n", + "i_search = 4\n", + "Looking for paths with length: 3 for node HSPB1_S78 and MTOR\n", + "i_search = 4\n", + "Looking for paths with length: 4 for node HSPB1_S78 and MTOR\n", + "looking for paths in the network with length: 0 for node HSPB1_S78 and JUN\n", + "looking for paths in the network with length: 1 for node HSPB1_S78 and JUN\n", + "looking for paths in the network with length: 2 for node HSPB1_S78 and JUN\n", + "looking for paths in the network with length: 3 for node HSPB1_S78 and JUN\n", + "looking for paths in the network with length: 4 for node HSPB1_S78 and JUN\n", + "looking for paths in the network with length: 5 for node HSPB1_S78 and JUN\n", + "looking for paths in the network with length: 6 for node HSPB1_S78 and JUN\n", + "looking for paths in the network with length: 7 for node HSPB1_S78 and JUN\n", + "looking for paths in the network with length: 8 for node HSPB1_S78 and JUN\n", + "looking for paths in the network with length: 9 for node HSPB1_S78 and JUN\n", + "looking for paths in the network with length: 10 for node HSPB1_S78 and JUN\n", + "i_search = 4\n", + "Looking for paths with length: 0 for node HSPB1_S78 and JUN\n", + "i_search = 4\n", + "Looking for paths with length: 1 for node HSPB1_S78 and JUN\n", + "i_search = 4\n", + "Looking for paths with length: 2 for node HSPB1_S78 and JUN\n", + "i_search = 4\n", + "Looking for paths with length: 3 for node HSPB1_S78 and JUN\n", + "i_search = 4\n", + "Looking for paths with length: 4 for node HSPB1_S78 and JUN\n", + "looking for paths in the network with length: 0 for node HSPB1_S78 and EGFR\n", + "looking for paths in the network with length: 1 for node HSPB1_S78 and EGFR\n", + "looking for paths in the network with length: 2 for node HSPB1_S78 and EGFR\n", + "looking for paths in the network with length: 3 for node HSPB1_S78 and EGFR\n", + "looking for paths in the network with length: 4 for node HSPB1_S78 and EGFR\n", + "looking for paths in the network with length: 5 for node HSPB1_S78 and EGFR\n", + "looking for paths in the network with length: 6 for node HSPB1_S78 and EGFR\n", + "looking for paths in the network with length: 7 for node HSPB1_S78 and EGFR\n", + "looking for paths in the network with length: 8 for node HSPB1_S78 and EGFR\n", + "looking for paths in the network with length: 9 for node HSPB1_S78 and EGFR\n", + "looking for paths in the network with length: 10 for node HSPB1_S78 and EGFR\n", + "i_search = 4\n", + "Looking for paths with length: 0 for node HSPB1_S78 and EGFR\n", + "i_search = 4\n", + "Looking for paths with length: 1 for node HSPB1_S78 and EGFR\n", + "i_search = 4\n", + "Looking for paths with length: 2 for node HSPB1_S78 and EGFR\n", + "i_search = 4\n", + "Looking for paths with length: 3 for node HSPB1_S78 and EGFR\n", + "i_search = 4\n", + "Looking for paths with length: 4 for node HSPB1_S78 and EGFR\n", + "looking for paths in the network with length: 0 for node HSPB1_S78 and MAPK3\n", + "looking for paths in the network with length: 1 for node HSPB1_S78 and MAPK3\n", + "looking for paths in the network with length: 2 for node HSPB1_S78 and MAPK3\n", + "looking for paths in the network with length: 3 for node HSPB1_S78 and MAPK3\n", + "looking for paths in the network with length: 4 for node HSPB1_S78 and MAPK3\n", + "looking for paths in the network with length: 5 for node HSPB1_S78 and MAPK3\n", + "looking for paths in the network with length: 6 for node HSPB1_S78 and MAPK3\n", + "looking for paths in the network with length: 7 for node HSPB1_S78 and MAPK3\n", + "looking for paths in the network with length: 8 for node HSPB1_S78 and MAPK3\n", + "looking for paths in the network with length: 9 for node HSPB1_S78 and MAPK3\n", + "looking for paths in the network with length: 10 for node HSPB1_S78 and MAPK3\n", + "i_search = 4\n", + "Looking for paths with length: 0 for node HSPB1_S78 and MAPK3\n", + "i_search = 4\n", + "Looking for paths with length: 1 for node HSPB1_S78 and MAPK3\n", + "i_search = 4\n", + "Looking for paths with length: 2 for node HSPB1_S78 and MAPK3\n", + "i_search = 4\n", + "Looking for paths with length: 3 for node HSPB1_S78 and MAPK3\n", + "i_search = 4\n", + "Looking for paths with length: 4 for node HSPB1_S78 and MAPK3\n", + "looking for paths in the network with length: 0 for node HSPB1_S78 and PTPN11\n", + "looking for paths in the network with length: 1 for node HSPB1_S78 and PTPN11\n", + "looking for paths in the network with length: 2 for node HSPB1_S78 and PTPN11\n", + "looking for paths in the network with length: 3 for node HSPB1_S78 and PTPN11\n", + "looking for paths in the network with length: 4 for node HSPB1_S78 and PTPN11\n", + "looking for paths in the network with length: 5 for node HSPB1_S78 and PTPN11\n", + "looking for paths in the network with length: 6 for node HSPB1_S78 and PTPN11\n", + "looking for paths in the network with length: 7 for node HSPB1_S78 and PTPN11\n", + "looking for paths in the network with length: 8 for node HSPB1_S78 and PTPN11\n", + "looking for paths in the network with length: 9 for node HSPB1_S78 and PTPN11\n", + "looking for paths in the network with length: 10 for node HSPB1_S78 and PTPN11\n", + "i_search = 4\n", + "Looking for paths with length: 0 for node HSPB1_S78 and PTPN11\n", + "i_search = 4\n", + "Looking for paths with length: 1 for node HSPB1_S78 and PTPN11\n", + "i_search = 4\n", + "Looking for paths with length: 2 for node HSPB1_S78 and PTPN11\n", + "i_search = 4\n", + "Looking for paths with length: 3 for node HSPB1_S78 and PTPN11\n", + "i_search = 4\n", + "Looking for paths with length: 4 for node HSPB1_S78 and PTPN11\n", + "looking for paths in the network with length: 0 for node HSPB1_S78 and STAT3\n", + "looking for paths in the network with length: 1 for node HSPB1_S78 and STAT3\n", + "looking for paths in the network with length: 2 for node HSPB1_S78 and STAT3\n", + "looking for paths in the network with length: 3 for node HSPB1_S78 and STAT3\n", + "looking for paths in the network with length: 4 for node HSPB1_S78 and STAT3\n", + "looking for paths in the network with length: 5 for node HSPB1_S78 and STAT3\n", + "looking for paths in the network with length: 6 for node HSPB1_S78 and STAT3\n", + "looking for paths in the network with length: 7 for node HSPB1_S78 and STAT3\n", + "looking for paths in the network with length: 8 for node HSPB1_S78 and STAT3\n", + "looking for paths in the network with length: 9 for node HSPB1_S78 and STAT3\n", + "looking for paths in the network with length: 10 for node HSPB1_S78 and STAT3\n", + "i_search = 4\n", + "Looking for paths with length: 0 for node HSPB1_S78 and STAT3\n", + "i_search = 4\n", + "Looking for paths with length: 1 for node HSPB1_S78 and STAT3\n", + "i_search = 4\n", + "Looking for paths with length: 2 for node HSPB1_S78 and STAT3\n", + "i_search = 4\n", + "Looking for paths with length: 3 for node HSPB1_S78 and STAT3\n", + "i_search = 4\n", + "Looking for paths with length: 4 for node HSPB1_S78 and STAT3\n", + "looking for paths in the network with length: 0 for node HSPB1_S78 and CHEK2\n", + "looking for paths in the network with length: 1 for node HSPB1_S78 and CHEK2\n", + "looking for paths in the network with length: 2 for node HSPB1_S78 and CHEK2\n", + "looking for paths in the network with length: 3 for node HSPB1_S78 and CHEK2\n", + "looking for paths in the network with length: 4 for node HSPB1_S78 and CHEK2\n", + "looking for paths in the network with length: 5 for node HSPB1_S78 and CHEK2\n", + "looking for paths in the network with length: 6 for node HSPB1_S78 and CHEK2\n", + "looking for paths in the network with length: 7 for node HSPB1_S78 and CHEK2\n", + "looking for paths in the network with length: 8 for node HSPB1_S78 and CHEK2\n", + "looking for paths in the network with length: 9 for node HSPB1_S78 and CHEK2\n", + "looking for paths in the network with length: 10 for node HSPB1_S78 and CHEK2\n", + "i_search = 4\n", + "Looking for paths with length: 0 for node HSPB1_S78 and CHEK2\n", + "i_search = 4\n", + "Looking for paths with length: 1 for node HSPB1_S78 and CHEK2\n", + "i_search = 4\n", + "Looking for paths with length: 2 for node HSPB1_S78 and CHEK2\n", + "i_search = 4\n", + "Looking for paths with length: 3 for node HSPB1_S78 and CHEK2\n", + "i_search = 4\n", + "Looking for paths with length: 4 for node HSPB1_S78 and CHEK2\n", + "looking for paths in the network with length: 0 for node HSPB1_S78 and RELA\n", + "looking for paths in the network with length: 1 for node HSPB1_S78 and RELA\n", + "looking for paths in the network with length: 2 for node HSPB1_S78 and RELA\n", + "looking for paths in the network with length: 3 for node HSPB1_S78 and RELA\n", + "looking for paths in the network with length: 4 for node HSPB1_S78 and RELA\n", + "looking for paths in the network with length: 5 for node HSPB1_S78 and RELA\n", + "looking for paths in the network with length: 6 for node HSPB1_S78 and RELA\n", + "looking for paths in the network with length: 7 for node HSPB1_S78 and RELA\n", + "looking for paths in the network with length: 8 for node HSPB1_S78 and RELA\n", + "looking for paths in the network with length: 9 for node HSPB1_S78 and RELA\n", + "looking for paths in the network with length: 10 for node HSPB1_S78 and RELA\n", + "i_search = 4\n", + "Looking for paths with length: 0 for node HSPB1_S78 and RELA\n", + "i_search = 4\n", + "Looking for paths with length: 1 for node HSPB1_S78 and RELA\n", + "i_search = 4\n", + "Looking for paths with length: 2 for node HSPB1_S78 and RELA\n", + "i_search = 4\n", + "Looking for paths with length: 3 for node HSPB1_S78 and RELA\n", + "i_search = 4\n", + "Looking for paths with length: 4 for node HSPB1_S78 and RELA\n", + "looking for paths in the network with length: 0 for node HSPB1_S78 and MARCKS\n", + "looking for paths in the network with length: 1 for node HSPB1_S78 and MARCKS\n", + "looking for paths in the network with length: 2 for node HSPB1_S78 and MARCKS\n", + "looking for paths in the network with length: 3 for node HSPB1_S78 and MARCKS\n", + "looking for paths in the network with length: 4 for node HSPB1_S78 and MARCKS\n", + "looking for paths in the network with length: 5 for node HSPB1_S78 and MARCKS\n", + "looking for paths in the network with length: 6 for node HSPB1_S78 and MARCKS\n", + "looking for paths in the network with length: 7 for node HSPB1_S78 and MARCKS\n", + "looking for paths in the network with length: 8 for node HSPB1_S78 and MARCKS\n", + "looking for paths in the network with length: 9 for node HSPB1_S78 and MARCKS\n", + "looking for paths in the network with length: 10 for node HSPB1_S78 and MARCKS\n", + "i_search = 4\n", + "Looking for paths with length: 0 for node HSPB1_S78 and MARCKS\n", + "i_search = 4\n", + "Looking for paths with length: 1 for node HSPB1_S78 and MARCKS\n", + "i_search = 4\n", + "Looking for paths with length: 2 for node HSPB1_S78 and MARCKS\n", + "i_search = 4\n", + "Looking for paths with length: 3 for node HSPB1_S78 and MARCKS\n", + "i_search = 4\n", + "Looking for paths with length: 4 for node HSPB1_S78 and MARCKS\n", + "looking for paths in the network with length: 0 for node HSPB1_S82 and MAPK14_T180\n", + "looking for paths in the network with length: 1 for node HSPB1_S82 and MAPK14_T180\n", + "looking for paths in the network with length: 2 for node HSPB1_S82 and MAPK14_T180\n", + "looking for paths in the network with length: 3 for node HSPB1_S82 and MAPK14_T180\n", + "looking for paths in the network with length: 4 for node HSPB1_S82 and MAPK14_T180\n", + "looking for paths in the network with length: 5 for node HSPB1_S82 and MAPK14_T180\n", + "looking for paths in the network with length: 6 for node HSPB1_S82 and MAPK14_T180\n", + "Found a path!\n", + "[['HSPB1_S82', 'AKT1', 'AKT1_S473', 'MAPKAPK2', 'MAPKAPK2_T334', 'MAPK14', 'MAPK14_T180'], ['HSPB1_S82', 'AKT1', 'AKT1_S473', 'MAPKAPK2', 'MAPKAPK2_S272', 'MAPK14', 'MAPK14_T180'], ['HSPB1_S82', 'AKT1', 'AKT1_S473', 'MAPKAPK2', 'MAPKAPK2_T222', 'MAPK14', 'MAPK14_T180']]\n", + "looking for paths in the network with length: 0 for node HSPB1_S82 and MAPK14_Y182\n", + "looking for paths in the network with length: 1 for node HSPB1_S82 and MAPK14_Y182\n", + "looking for paths in the network with length: 2 for node HSPB1_S82 and MAPK14_Y182\n", + "looking for paths in the network with length: 3 for node HSPB1_S82 and MAPK14_Y182\n", + "looking for paths in the network with length: 4 for node HSPB1_S82 and MAPK14_Y182\n", + "looking for paths in the network with length: 5 for node HSPB1_S82 and MAPK14_Y182\n", + "looking for paths in the network with length: 6 for node HSPB1_S82 and MAPK14_Y182\n", + "Found a path!\n", + "[['HSPB1_S82', 'AKT1', 'AKT1_S473', 'MAPKAPK2', 'MAPKAPK2_T334', 'MAPK14', 'MAPK14_Y182'], ['HSPB1_S82', 'AKT1', 'AKT1_S473', 'MAPKAPK2', 'MAPKAPK2_S272', 'MAPK14', 'MAPK14_Y182'], ['HSPB1_S82', 'AKT1', 'AKT1_S473', 'MAPKAPK2', 'MAPKAPK2_T222', 'MAPK14', 'MAPK14_Y182']]\n", + "looking for paths in the network with length: 0 for node HSPB1_S82 and MAP2K1_S218\n", + "looking for paths in the network with length: 1 for node HSPB1_S82 and MAP2K1_S218\n", + "looking for paths in the network with length: 2 for node HSPB1_S82 and MAP2K1_S218\n", + "looking for paths in the network with length: 3 for node HSPB1_S82 and MAP2K1_S218\n", + "looking for paths in the network with length: 4 for node HSPB1_S82 and MAP2K1_S218\n", + "looking for paths in the network with length: 5 for node HSPB1_S82 and MAP2K1_S218\n", + "looking for paths in the network with length: 6 for node HSPB1_S82 and MAP2K1_S218\n", + "looking for paths in the network with length: 7 for node HSPB1_S82 and MAP2K1_S218\n", + "looking for paths in the network with length: 8 for node HSPB1_S82 and MAP2K1_S218\n", + "looking for paths in the network with length: 9 for node HSPB1_S82 and MAP2K1_S218\n", + "looking for paths in the network with length: 10 for node HSPB1_S82 and MAP2K1_S218\n", + "i_search = 4\n", + "Looking for paths with length: 0 for node HSPB1_S82 and MAP2K1_S218\n", + "i_search = 4\n", + "Looking for paths with length: 1 for node HSPB1_S82 and MAP2K1_S218\n", + "i_search = 4\n", + "Looking for paths with length: 2 for node HSPB1_S82 and MAP2K1_S218\n", + "i_search = 4\n", + "Looking for paths with length: 3 for node HSPB1_S82 and MAP2K1_S218\n", + "i_search = 4\n", + "Looking for paths with length: 4 for node HSPB1_S82 and MAP2K1_S218\n", + "looking for paths in the network with length: 0 for node HSPB1_S82 and MAP2K1_S222\n", + "looking for paths in the network with length: 1 for node HSPB1_S82 and MAP2K1_S222\n", + "looking for paths in the network with length: 2 for node HSPB1_S82 and MAP2K1_S222\n", + "looking for paths in the network with length: 3 for node HSPB1_S82 and MAP2K1_S222\n", + "looking for paths in the network with length: 4 for node HSPB1_S82 and MAP2K1_S222\n", + "looking for paths in the network with length: 5 for node HSPB1_S82 and MAP2K1_S222\n", + "looking for paths in the network with length: 6 for node HSPB1_S82 and MAP2K1_S222\n", + "looking for paths in the network with length: 7 for node HSPB1_S82 and MAP2K1_S222\n", + "looking for paths in the network with length: 8 for node HSPB1_S82 and MAP2K1_S222\n", + "looking for paths in the network with length: 9 for node HSPB1_S82 and MAP2K1_S222\n", + "looking for paths in the network with length: 10 for node HSPB1_S82 and MAP2K1_S222\n", + "i_search = 4\n", + "Looking for paths with length: 0 for node HSPB1_S82 and MAP2K1_S222\n", + "i_search = 4\n", + "Looking for paths with length: 1 for node HSPB1_S82 and MAP2K1_S222\n", + "i_search = 4\n", + "Looking for paths with length: 2 for node HSPB1_S82 and MAP2K1_S222\n", + "i_search = 4\n", + "Looking for paths with length: 3 for node HSPB1_S82 and MAP2K1_S222\n", + "i_search = 4\n", + "Looking for paths with length: 4 for node HSPB1_S82 and MAP2K1_S222\n", + "looking for paths in the network with length: 0 for node HSPB1_S82 and RPS6KA1_S380\n", + "looking for paths in the network with length: 1 for node HSPB1_S82 and RPS6KA1_S380\n", + "looking for paths in the network with length: 2 for node HSPB1_S82 and RPS6KA1_S380\n", + "looking for paths in the network with length: 3 for node HSPB1_S82 and RPS6KA1_S380\n", + "looking for paths in the network with length: 4 for node HSPB1_S82 and RPS6KA1_S380\n", + "looking for paths in the network with length: 5 for node HSPB1_S82 and RPS6KA1_S380\n", + "looking for paths in the network with length: 6 for node HSPB1_S82 and RPS6KA1_S380\n", + "looking for paths in the network with length: 7 for node HSPB1_S82 and RPS6KA1_S380\n", + "looking for paths in the network with length: 8 for node HSPB1_S82 and RPS6KA1_S380\n", + "looking for paths in the network with length: 9 for node HSPB1_S82 and RPS6KA1_S380\n", + "looking for paths in the network with length: 10 for node HSPB1_S82 and RPS6KA1_S380\n", + "i_search = 4\n", + "Looking for paths with length: 0 for node HSPB1_S82 and RPS6KA1_S380\n", + "i_search = 4\n", + "Looking for paths with length: 1 for node HSPB1_S82 and RPS6KA1_S380\n", + "i_search = 4\n", + "Looking for paths with length: 2 for node HSPB1_S82 and RPS6KA1_S380\n", + "i_search = 4\n", + "Looking for paths with length: 3 for node HSPB1_S82 and RPS6KA1_S380\n", + "i_search = 4\n", + "Looking for paths with length: 4 for node HSPB1_S82 and RPS6KA1_S380\n", + "looking for paths in the network with length: 0 for node HSPB1_S82 and CREB1_S133\n", + "looking for paths in the network with length: 1 for node HSPB1_S82 and CREB1_S133\n", + "looking for paths in the network with length: 2 for node HSPB1_S82 and CREB1_S133\n", + "looking for paths in the network with length: 3 for node HSPB1_S82 and CREB1_S133\n", + "looking for paths in the network with length: 4 for node HSPB1_S82 and CREB1_S133\n", + "looking for paths in the network with length: 5 for node HSPB1_S82 and CREB1_S133\n", + "looking for paths in the network with length: 6 for node HSPB1_S82 and CREB1_S133\n", + "looking for paths in the network with length: 7 for node HSPB1_S82 and CREB1_S133\n", + "looking for paths in the network with length: 8 for node HSPB1_S82 and CREB1_S133\n", + "looking for paths in the network with length: 9 for node HSPB1_S82 and CREB1_S133\n", + "looking for paths in the network with length: 10 for node HSPB1_S82 and CREB1_S133\n", + "i_search = 4\n", + "Looking for paths with length: 0 for node HSPB1_S82 and CREB1_S133\n", + "i_search = 4\n", + "Looking for paths with length: 1 for node HSPB1_S82 and CREB1_S133\n", + "i_search = 4\n", + "Looking for paths with length: 2 for node HSPB1_S82 and CREB1_S133\n", + "i_search = 4\n", + "Looking for paths with length: 3 for node HSPB1_S82 and CREB1_S133\n", + "i_search = 4\n", + "Looking for paths with length: 4 for node HSPB1_S82 and CREB1_S133\n", + "looking for paths in the network with length: 0 for node HSPB1_S82 and NFKBIA_S32\n", + "looking for paths in the network with length: 1 for node HSPB1_S82 and NFKBIA_S32\n", + "looking for paths in the network with length: 2 for node HSPB1_S82 and NFKBIA_S32\n", + "looking for paths in the network with length: 3 for node HSPB1_S82 and NFKBIA_S32\n", + "looking for paths in the network with length: 4 for node HSPB1_S82 and NFKBIA_S32\n", + "looking for paths in the network with length: 5 for node HSPB1_S82 and NFKBIA_S32\n", + "looking for paths in the network with length: 6 for node HSPB1_S82 and NFKBIA_S32\n", + "looking for paths in the network with length: 7 for node HSPB1_S82 and NFKBIA_S32\n", + "looking for paths in the network with length: 8 for node HSPB1_S82 and NFKBIA_S32\n", + "looking for paths in the network with length: 9 for node HSPB1_S82 and NFKBIA_S32\n", + "looking for paths in the network with length: 10 for node HSPB1_S82 and NFKBIA_S32\n", + "i_search = 4\n", + "Looking for paths with length: 0 for node HSPB1_S82 and NFKBIA_S32\n", + "i_search = 4\n", + "Looking for paths with length: 1 for node HSPB1_S82 and NFKBIA_S32\n", + "i_search = 4\n", + "Looking for paths with length: 2 for node HSPB1_S82 and NFKBIA_S32\n", + "i_search = 4\n", + "Looking for paths with length: 3 for node HSPB1_S82 and NFKBIA_S32\n", + "i_search = 4\n", + "Looking for paths with length: 4 for node HSPB1_S82 and NFKBIA_S32\n", + "looking for paths in the network with length: 0 for node HSPB1_S82 and NFKBIA_S36\n", + "looking for paths in the network with length: 1 for node HSPB1_S82 and NFKBIA_S36\n", + "looking for paths in the network with length: 2 for node HSPB1_S82 and NFKBIA_S36\n", + "looking for paths in the network with length: 3 for node HSPB1_S82 and NFKBIA_S36\n", + "looking for paths in the network with length: 4 for node HSPB1_S82 and NFKBIA_S36\n", + "looking for paths in the network with length: 5 for node HSPB1_S82 and NFKBIA_S36\n", + "looking for paths in the network with length: 6 for node HSPB1_S82 and NFKBIA_S36\n", + "looking for paths in the network with length: 7 for node HSPB1_S82 and NFKBIA_S36\n", + "looking for paths in the network with length: 8 for node HSPB1_S82 and NFKBIA_S36\n", + "looking for paths in the network with length: 9 for node HSPB1_S82 and NFKBIA_S36\n", + "looking for paths in the network with length: 10 for node HSPB1_S82 and NFKBIA_S36\n", + "i_search = 4\n", + "Looking for paths with length: 0 for node HSPB1_S82 and NFKBIA_S36\n", + "i_search = 4\n", + "Looking for paths with length: 1 for node HSPB1_S82 and NFKBIA_S36\n", + "i_search = 4\n", + "Looking for paths with length: 2 for node HSPB1_S82 and NFKBIA_S36\n", + "i_search = 4\n", + "Looking for paths with length: 3 for node HSPB1_S82 and NFKBIA_S36\n", + "i_search = 4\n", + "Looking for paths with length: 4 for node HSPB1_S82 and NFKBIA_S36\n", + "looking for paths in the network with length: 0 for node HSPB1_S82 and MTOR_S2448\n", + "looking for paths in the network with length: 1 for node HSPB1_S82 and MTOR_S2448\n", + "looking for paths in the network with length: 2 for node HSPB1_S82 and MTOR_S2448\n", + "looking for paths in the network with length: 3 for node HSPB1_S82 and MTOR_S2448\n", + "looking for paths in the network with length: 4 for node HSPB1_S82 and MTOR_S2448\n", + "looking for paths in the network with length: 5 for node HSPB1_S82 and MTOR_S2448\n", + "looking for paths in the network with length: 6 for node HSPB1_S82 and MTOR_S2448\n", + "looking for paths in the network with length: 7 for node HSPB1_S82 and MTOR_S2448\n", + "looking for paths in the network with length: 8 for node HSPB1_S82 and MTOR_S2448\n", + "looking for paths in the network with length: 9 for node HSPB1_S82 and MTOR_S2448\n", + "looking for paths in the network with length: 10 for node HSPB1_S82 and MTOR_S2448\n", + "i_search = 4\n", + "Looking for paths with length: 0 for node HSPB1_S82 and MTOR_S2448\n", + "i_search = 4\n", + "Looking for paths with length: 1 for node HSPB1_S82 and MTOR_S2448\n", + "i_search = 4\n", + "Looking for paths with length: 2 for node HSPB1_S82 and MTOR_S2448\n", + "i_search = 4\n", + "Looking for paths with length: 3 for node HSPB1_S82 and MTOR_S2448\n", + "i_search = 4\n", + "Looking for paths with length: 4 for node HSPB1_S82 and MTOR_S2448\n", + "[['HSPB1_S82', 'AKT1', 'AKT1_S473', 'MTOR', 'MTOR_S2448'], ['HSPB1_S82', 'AKT1', 'AKT1_T450', 'MTOR', 'MTOR_S2448']]\n", + "AKT1 HSPB1_S82\n", + "AKT1_S473 AKT1\n", + "MTOR AKT1_S473\n", + "MTOR MTOR_S2448\n", + "AKT1 HSPB1_S82\n", + "AKT1_T450 AKT1\n", + "MTOR AKT1_T450\n", + "MTOR MTOR_S2448\n", + "looking for paths in the network with length: 0 for node HSPB1_S82 and JUN_S63\n", + "looking for paths in the network with length: 1 for node HSPB1_S82 and JUN_S63\n", + "looking for paths in the network with length: 2 for node HSPB1_S82 and JUN_S63\n", + "looking for paths in the network with length: 3 for node HSPB1_S82 and JUN_S63\n", + "looking for paths in the network with length: 4 for node HSPB1_S82 and JUN_S63\n", + "looking for paths in the network with length: 5 for node HSPB1_S82 and JUN_S63\n", + "looking for paths in the network with length: 6 for node HSPB1_S82 and JUN_S63\n", + "looking for paths in the network with length: 7 for node HSPB1_S82 and JUN_S63\n", + "looking for paths in the network with length: 8 for node HSPB1_S82 and JUN_S63\n", + "looking for paths in the network with length: 9 for node HSPB1_S82 and JUN_S63\n", + "looking for paths in the network with length: 10 for node HSPB1_S82 and JUN_S63\n", + "i_search = 4\n", + "Looking for paths with length: 0 for node HSPB1_S82 and JUN_S63\n", + "i_search = 4\n", + "Looking for paths with length: 1 for node HSPB1_S82 and JUN_S63\n", + "i_search = 4\n", + "Looking for paths with length: 2 for node HSPB1_S82 and JUN_S63\n", + "i_search = 4\n", + "Looking for paths with length: 3 for node HSPB1_S82 and JUN_S63\n", + "i_search = 4\n", + "Looking for paths with length: 4 for node HSPB1_S82 and JUN_S63\n", + "looking for paths in the network with length: 0 for node HSPB1_S82 and EGFR_Y1068\n", + "looking for paths in the network with length: 1 for node HSPB1_S82 and EGFR_Y1068\n", + "looking for paths in the network with length: 2 for node HSPB1_S82 and EGFR_Y1068\n", + "looking for paths in the network with length: 3 for node HSPB1_S82 and EGFR_Y1068\n", + "looking for paths in the network with length: 4 for node HSPB1_S82 and EGFR_Y1068\n", + "looking for paths in the network with length: 5 for node HSPB1_S82 and EGFR_Y1068\n", + "looking for paths in the network with length: 6 for node HSPB1_S82 and EGFR_Y1068\n", + "looking for paths in the network with length: 7 for node HSPB1_S82 and EGFR_Y1068\n", + "looking for paths in the network with length: 8 for node HSPB1_S82 and EGFR_Y1068\n", + "looking for paths in the network with length: 9 for node HSPB1_S82 and EGFR_Y1068\n", + "looking for paths in the network with length: 10 for node HSPB1_S82 and EGFR_Y1068\n", + "i_search = 4\n", + "Looking for paths with length: 0 for node HSPB1_S82 and EGFR_Y1068\n", + "i_search = 4\n", + "Looking for paths with length: 1 for node HSPB1_S82 and EGFR_Y1068\n", + "i_search = 4\n", + "Looking for paths with length: 2 for node HSPB1_S82 and EGFR_Y1068\n", + "i_search = 4\n", + "Looking for paths with length: 3 for node HSPB1_S82 and EGFR_Y1068\n", + "i_search = 4\n", + "Looking for paths with length: 4 for node HSPB1_S82 and EGFR_Y1068\n", + "looking for paths in the network with length: 0 for node HSPB1_S82 and MAPK3_T202\n", + "looking for paths in the network with length: 1 for node HSPB1_S82 and MAPK3_T202\n", + "looking for paths in the network with length: 2 for node HSPB1_S82 and MAPK3_T202\n", + "looking for paths in the network with length: 3 for node HSPB1_S82 and MAPK3_T202\n", + "looking for paths in the network with length: 4 for node HSPB1_S82 and MAPK3_T202\n", + "looking for paths in the network with length: 5 for node HSPB1_S82 and MAPK3_T202\n", + "looking for paths in the network with length: 6 for node HSPB1_S82 and MAPK3_T202\n", + "looking for paths in the network with length: 7 for node HSPB1_S82 and MAPK3_T202\n", + "looking for paths in the network with length: 8 for node HSPB1_S82 and MAPK3_T202\n", + "looking for paths in the network with length: 9 for node HSPB1_S82 and MAPK3_T202\n", + "looking for paths in the network with length: 10 for node HSPB1_S82 and MAPK3_T202\n", + "i_search = 4\n", + "Looking for paths with length: 0 for node HSPB1_S82 and MAPK3_T202\n", + "i_search = 4\n", + "Looking for paths with length: 1 for node HSPB1_S82 and MAPK3_T202\n", + "i_search = 4\n", + "Looking for paths with length: 2 for node HSPB1_S82 and MAPK3_T202\n", + "i_search = 4\n", + "Looking for paths with length: 3 for node HSPB1_S82 and MAPK3_T202\n", + "i_search = 4\n", + "Looking for paths with length: 4 for node HSPB1_S82 and MAPK3_T202\n", + "looking for paths in the network with length: 0 for node HSPB1_S82 and MAPK3_Y204\n", + "looking for paths in the network with length: 1 for node HSPB1_S82 and MAPK3_Y204\n", + "looking for paths in the network with length: 2 for node HSPB1_S82 and MAPK3_Y204\n", + "looking for paths in the network with length: 3 for node HSPB1_S82 and MAPK3_Y204\n", + "looking for paths in the network with length: 4 for node HSPB1_S82 and MAPK3_Y204\n", + "looking for paths in the network with length: 5 for node HSPB1_S82 and MAPK3_Y204\n", + "looking for paths in the network with length: 6 for node HSPB1_S82 and MAPK3_Y204\n", + "looking for paths in the network with length: 7 for node HSPB1_S82 and MAPK3_Y204\n", + "looking for paths in the network with length: 8 for node HSPB1_S82 and MAPK3_Y204\n", + "looking for paths in the network with length: 9 for node HSPB1_S82 and MAPK3_Y204\n", + "looking for paths in the network with length: 10 for node HSPB1_S82 and MAPK3_Y204\n", + "i_search = 4\n", + "Looking for paths with length: 0 for node HSPB1_S82 and MAPK3_Y204\n", + "i_search = 4\n", + "Looking for paths with length: 1 for node HSPB1_S82 and MAPK3_Y204\n", + "i_search = 4\n", + "Looking for paths with length: 2 for node HSPB1_S82 and MAPK3_Y204\n", + "i_search = 4\n", + "Looking for paths with length: 3 for node HSPB1_S82 and MAPK3_Y204\n", + "i_search = 4\n", + "Looking for paths with length: 4 for node HSPB1_S82 and MAPK3_Y204\n", + "looking for paths in the network with length: 0 for node HSPB1_S82 and PTPN11_Y542\n", + "looking for paths in the network with length: 1 for node HSPB1_S82 and PTPN11_Y542\n", + "looking for paths in the network with length: 2 for node HSPB1_S82 and PTPN11_Y542\n", + "looking for paths in the network with length: 3 for node HSPB1_S82 and PTPN11_Y542\n", + "looking for paths in the network with length: 4 for node HSPB1_S82 and PTPN11_Y542\n", + "looking for paths in the network with length: 5 for node HSPB1_S82 and PTPN11_Y542\n", + "looking for paths in the network with length: 6 for node HSPB1_S82 and PTPN11_Y542\n", + "looking for paths in the network with length: 7 for node HSPB1_S82 and PTPN11_Y542\n", + "looking for paths in the network with length: 8 for node HSPB1_S82 and PTPN11_Y542\n", + "looking for paths in the network with length: 9 for node HSPB1_S82 and PTPN11_Y542\n", + "looking for paths in the network with length: 10 for node HSPB1_S82 and PTPN11_Y542\n", + "i_search = 4\n", + "Looking for paths with length: 0 for node HSPB1_S82 and PTPN11_Y542\n", + "i_search = 4\n", + "Looking for paths with length: 1 for node HSPB1_S82 and PTPN11_Y542\n", + "i_search = 4\n", + "Looking for paths with length: 2 for node HSPB1_S82 and PTPN11_Y542\n", + "i_search = 4\n", + "Looking for paths with length: 3 for node HSPB1_S82 and PTPN11_Y542\n", + "i_search = 4\n", + "Looking for paths with length: 4 for node HSPB1_S82 and PTPN11_Y542\n", + "looking for paths in the network with length: 0 for node HSPB1_S82 and STAT3_Y705\n", + "looking for paths in the network with length: 1 for node HSPB1_S82 and STAT3_Y705\n", + "looking for paths in the network with length: 2 for node HSPB1_S82 and STAT3_Y705\n", + "looking for paths in the network with length: 3 for node HSPB1_S82 and STAT3_Y705\n", + "looking for paths in the network with length: 4 for node HSPB1_S82 and STAT3_Y705\n", + "looking for paths in the network with length: 5 for node HSPB1_S82 and STAT3_Y705\n", + "looking for paths in the network with length: 6 for node HSPB1_S82 and STAT3_Y705\n", + "looking for paths in the network with length: 7 for node HSPB1_S82 and STAT3_Y705\n", + "looking for paths in the network with length: 8 for node HSPB1_S82 and STAT3_Y705\n", + "looking for paths in the network with length: 9 for node HSPB1_S82 and STAT3_Y705\n", + "looking for paths in the network with length: 10 for node HSPB1_S82 and STAT3_Y705\n", + "i_search = 4\n", + "Looking for paths with length: 0 for node HSPB1_S82 and STAT3_Y705\n", + "i_search = 4\n", + "Looking for paths with length: 1 for node HSPB1_S82 and STAT3_Y705\n", + "i_search = 4\n", + "Looking for paths with length: 2 for node HSPB1_S82 and STAT3_Y705\n", + "i_search = 4\n", + "Looking for paths with length: 3 for node HSPB1_S82 and STAT3_Y705\n", + "i_search = 4\n", + "Looking for paths with length: 4 for node HSPB1_S82 and STAT3_Y705\n", + "looking for paths in the network with length: 0 for node HSPB1_S82 and CHEK2_T68\n", + "looking for paths in the network with length: 1 for node HSPB1_S82 and CHEK2_T68\n", + "looking for paths in the network with length: 2 for node HSPB1_S82 and CHEK2_T68\n", + "looking for paths in the network with length: 3 for node HSPB1_S82 and CHEK2_T68\n", + "looking for paths in the network with length: 4 for node HSPB1_S82 and CHEK2_T68\n", + "looking for paths in the network with length: 5 for node HSPB1_S82 and CHEK2_T68\n", + "looking for paths in the network with length: 6 for node HSPB1_S82 and CHEK2_T68\n", + "looking for paths in the network with length: 7 for node HSPB1_S82 and CHEK2_T68\n", + "looking for paths in the network with length: 8 for node HSPB1_S82 and CHEK2_T68\n", + "looking for paths in the network with length: 9 for node HSPB1_S82 and CHEK2_T68\n", + "looking for paths in the network with length: 10 for node HSPB1_S82 and CHEK2_T68\n", + "i_search = 4\n", + "Looking for paths with length: 0 for node HSPB1_S82 and CHEK2_T68\n", + "i_search = 4\n", + "Looking for paths with length: 1 for node HSPB1_S82 and CHEK2_T68\n", + "i_search = 4\n", + "Looking for paths with length: 2 for node HSPB1_S82 and CHEK2_T68\n", + "i_search = 4\n", + "Looking for paths with length: 3 for node HSPB1_S82 and CHEK2_T68\n", + "i_search = 4\n", + "Looking for paths with length: 4 for node HSPB1_S82 and CHEK2_T68\n", + "looking for paths in the network with length: 0 for node HSPB1_S82 and RELA_S536\n", + "looking for paths in the network with length: 1 for node HSPB1_S82 and RELA_S536\n", + "looking for paths in the network with length: 2 for node HSPB1_S82 and RELA_S536\n", + "looking for paths in the network with length: 3 for node HSPB1_S82 and RELA_S536\n", + "looking for paths in the network with length: 4 for node HSPB1_S82 and RELA_S536\n", + "looking for paths in the network with length: 5 for node HSPB1_S82 and RELA_S536\n", + "looking for paths in the network with length: 6 for node HSPB1_S82 and RELA_S536\n", + "looking for paths in the network with length: 7 for node HSPB1_S82 and RELA_S536\n", + "looking for paths in the network with length: 8 for node HSPB1_S82 and RELA_S536\n", + "looking for paths in the network with length: 9 for node HSPB1_S82 and RELA_S536\n", + "looking for paths in the network with length: 10 for node HSPB1_S82 and RELA_S536\n", + "i_search = 4\n", + "Looking for paths with length: 0 for node HSPB1_S82 and RELA_S536\n", + "i_search = 4\n", + "Looking for paths with length: 1 for node HSPB1_S82 and RELA_S536\n", + "i_search = 4\n", + "Looking for paths with length: 2 for node HSPB1_S82 and RELA_S536\n", + "i_search = 4\n", + "Looking for paths with length: 3 for node HSPB1_S82 and RELA_S536\n", + "i_search = 4\n", + "Looking for paths with length: 4 for node HSPB1_S82 and RELA_S536\n", + "looking for paths in the network with length: 0 for node HSPB1_S82 and MARCKS_S170\n", + "looking for paths in the network with length: 1 for node HSPB1_S82 and MARCKS_S170\n", + "looking for paths in the network with length: 2 for node HSPB1_S82 and MARCKS_S170\n", + "looking for paths in the network with length: 3 for node HSPB1_S82 and MARCKS_S170\n", + "looking for paths in the network with length: 4 for node HSPB1_S82 and MARCKS_S170\n", + "looking for paths in the network with length: 5 for node HSPB1_S82 and MARCKS_S170\n", + "looking for paths in the network with length: 6 for node HSPB1_S82 and MARCKS_S170\n", + "looking for paths in the network with length: 7 for node HSPB1_S82 and MARCKS_S170\n", + "looking for paths in the network with length: 8 for node HSPB1_S82 and MARCKS_S170\n", + "looking for paths in the network with length: 9 for node HSPB1_S82 and MARCKS_S170\n", + "looking for paths in the network with length: 10 for node HSPB1_S82 and MARCKS_S170\n", + "i_search = 4\n", + "Looking for paths with length: 0 for node HSPB1_S82 and MARCKS_S170\n", + "i_search = 4\n", + "Looking for paths with length: 1 for node HSPB1_S82 and MARCKS_S170\n", + "i_search = 4\n", + "Looking for paths with length: 2 for node HSPB1_S82 and MARCKS_S170\n", + "i_search = 4\n", + "Looking for paths with length: 3 for node HSPB1_S82 and MARCKS_S170\n", + "i_search = 4\n", + "Looking for paths with length: 4 for node HSPB1_S82 and MARCKS_S170\n", + "looking for paths in the network with length: 0 for node HSPB1_S82 and SMAD3\n", + "looking for paths in the network with length: 1 for node HSPB1_S82 and SMAD3\n", + "looking for paths in the network with length: 2 for node HSPB1_S82 and SMAD3\n", + "looking for paths in the network with length: 3 for node HSPB1_S82 and SMAD3\n", + "looking for paths in the network with length: 4 for node HSPB1_S82 and SMAD3\n", + "looking for paths in the network with length: 5 for node HSPB1_S82 and SMAD3\n", + "looking for paths in the network with length: 6 for node HSPB1_S82 and SMAD3\n", + "looking for paths in the network with length: 7 for node HSPB1_S82 and SMAD3\n", + "looking for paths in the network with length: 8 for node HSPB1_S82 and SMAD3\n", + "looking for paths in the network with length: 9 for node HSPB1_S82 and SMAD3\n", + "looking for paths in the network with length: 10 for node HSPB1_S82 and SMAD3\n", + "i_search = 4\n", + "Looking for paths with length: 0 for node HSPB1_S82 and SMAD3\n", + "i_search = 4\n", + "Looking for paths with length: 1 for node HSPB1_S82 and SMAD3\n", + "i_search = 4\n", + "Looking for paths with length: 2 for node HSPB1_S82 and SMAD3\n", + "i_search = 4\n", + "Looking for paths with length: 3 for node HSPB1_S82 and SMAD3\n", + "i_search = 4\n", + "Looking for paths with length: 4 for node HSPB1_S82 and SMAD3\n", + "looking for paths in the network with length: 0 for node HSPB1_S82 and TP53\n", + "looking for paths in the network with length: 1 for node HSPB1_S82 and TP53\n", + "looking for paths in the network with length: 2 for node HSPB1_S82 and TP53\n", + "looking for paths in the network with length: 3 for node HSPB1_S82 and TP53\n", + "looking for paths in the network with length: 4 for node HSPB1_S82 and TP53\n", + "looking for paths in the network with length: 5 for node HSPB1_S82 and TP53\n", + "looking for paths in the network with length: 6 for node HSPB1_S82 and TP53\n", + "looking for paths in the network with length: 7 for node HSPB1_S82 and TP53\n", + "looking for paths in the network with length: 8 for node HSPB1_S82 and TP53\n", + "looking for paths in the network with length: 9 for node HSPB1_S82 and TP53\n", + "looking for paths in the network with length: 10 for node HSPB1_S82 and TP53\n", + "i_search = 4\n", + "Looking for paths with length: 0 for node HSPB1_S82 and TP53\n", + "i_search = 4\n", + "Looking for paths with length: 1 for node HSPB1_S82 and TP53\n", + "i_search = 4\n", + "Looking for paths with length: 2 for node HSPB1_S82 and TP53\n", + "i_search = 4\n", + "Looking for paths with length: 3 for node HSPB1_S82 and TP53\n", + "i_search = 4\n", + "Looking for paths with length: 4 for node HSPB1_S82 and TP53\n", + "looking for paths in the network with length: 0 for node HSPB1_S82 and AKT1S1\n", + "looking for paths in the network with length: 1 for node HSPB1_S82 and AKT1S1\n", + "looking for paths in the network with length: 2 for node HSPB1_S82 and AKT1S1\n", + "looking for paths in the network with length: 3 for node HSPB1_S82 and AKT1S1\n", + "looking for paths in the network with length: 4 for node HSPB1_S82 and AKT1S1\n", + "looking for paths in the network with length: 5 for node HSPB1_S82 and AKT1S1\n", + "looking for paths in the network with length: 6 for node HSPB1_S82 and AKT1S1\n", + "looking for paths in the network with length: 7 for node HSPB1_S82 and AKT1S1\n", + "looking for paths in the network with length: 8 for node HSPB1_S82 and AKT1S1\n", + "looking for paths in the network with length: 9 for node HSPB1_S82 and AKT1S1\n", + "looking for paths in the network with length: 10 for node HSPB1_S82 and AKT1S1\n", + "i_search = 4\n", + "Looking for paths with length: 0 for node HSPB1_S82 and AKT1S1\n", + "i_search = 4\n", + "Looking for paths with length: 1 for node HSPB1_S82 and AKT1S1\n", + "i_search = 4\n", + "Looking for paths with length: 2 for node HSPB1_S82 and AKT1S1\n", + "i_search = 4\n", + "Looking for paths with length: 3 for node HSPB1_S82 and AKT1S1\n", + "i_search = 4\n", + "Looking for paths with length: 4 for node HSPB1_S82 and AKT1S1\n", + "looking for paths in the network with length: 0 for node HSPB1_S82 and GSK3B\n", + "looking for paths in the network with length: 1 for node HSPB1_S82 and GSK3B\n", + "looking for paths in the network with length: 2 for node HSPB1_S82 and GSK3B\n", + "looking for paths in the network with length: 3 for node HSPB1_S82 and GSK3B\n", + "looking for paths in the network with length: 4 for node HSPB1_S82 and GSK3B\n", + "looking for paths in the network with length: 5 for node HSPB1_S82 and GSK3B\n", + "looking for paths in the network with length: 6 for node HSPB1_S82 and GSK3B\n", + "looking for paths in the network with length: 7 for node HSPB1_S82 and GSK3B\n", + "looking for paths in the network with length: 8 for node HSPB1_S82 and GSK3B\n", + "looking for paths in the network with length: 9 for node HSPB1_S82 and GSK3B\n", + "looking for paths in the network with length: 10 for node HSPB1_S82 and GSK3B\n", + "i_search = 4\n", + "Looking for paths with length: 0 for node HSPB1_S82 and GSK3B\n", + "i_search = 4\n", + "Looking for paths with length: 1 for node HSPB1_S82 and GSK3B\n", + "i_search = 4\n", + "Looking for paths with length: 2 for node HSPB1_S82 and GSK3B\n", + "i_search = 4\n", + "Looking for paths with length: 3 for node HSPB1_S82 and GSK3B\n", + "i_search = 4\n", + "Looking for paths with length: 4 for node HSPB1_S82 and GSK3B\n", + "looking for paths in the network with length: 0 for node HSPB1_S82 and AKT1\n", + "looking for paths in the network with length: 1 for node HSPB1_S82 and AKT1\n", + "looking for paths in the network with length: 2 for node HSPB1_S82 and AKT1\n", + "looking for paths in the network with length: 3 for node HSPB1_S82 and AKT1\n", + "looking for paths in the network with length: 4 for node HSPB1_S82 and AKT1\n", + "looking for paths in the network with length: 5 for node HSPB1_S82 and AKT1\n", + "looking for paths in the network with length: 6 for node HSPB1_S82 and AKT1\n", + "looking for paths in the network with length: 7 for node HSPB1_S82 and AKT1\n", + "looking for paths in the network with length: 8 for node HSPB1_S82 and AKT1\n", + "looking for paths in the network with length: 9 for node HSPB1_S82 and AKT1\n", + "looking for paths in the network with length: 10 for node HSPB1_S82 and AKT1\n", + "i_search = 4\n", + "Looking for paths with length: 0 for node HSPB1_S82 and AKT1\n", + "i_search = 4\n", + "Looking for paths with length: 1 for node HSPB1_S82 and AKT1\n", + "i_search = 4\n", + "Looking for paths with length: 2 for node HSPB1_S82 and AKT1\n", + "i_search = 4\n", + "Looking for paths with length: 3 for node HSPB1_S82 and AKT1\n", + "i_search = 4\n", + "Looking for paths with length: 4 for node HSPB1_S82 and AKT1\n", + "looking for paths in the network with length: 0 for node HSPB1_S82 and HSPB1\n", + "looking for paths in the network with length: 1 for node HSPB1_S82 and HSPB1\n", + "looking for paths in the network with length: 2 for node HSPB1_S82 and HSPB1\n", + "looking for paths in the network with length: 3 for node HSPB1_S82 and HSPB1\n", + "looking for paths in the network with length: 4 for node HSPB1_S82 and HSPB1\n", + "looking for paths in the network with length: 5 for node HSPB1_S82 and HSPB1\n", + "looking for paths in the network with length: 6 for node HSPB1_S82 and HSPB1\n", + "looking for paths in the network with length: 7 for node HSPB1_S82 and HSPB1\n", + "looking for paths in the network with length: 8 for node HSPB1_S82 and HSPB1\n", + "looking for paths in the network with length: 9 for node HSPB1_S82 and HSPB1\n", + "looking for paths in the network with length: 10 for node HSPB1_S82 and HSPB1\n", + "i_search = 4\n", + "Looking for paths with length: 0 for node HSPB1_S82 and HSPB1\n", + "i_search = 4\n", + "Looking for paths with length: 1 for node HSPB1_S82 and HSPB1\n", + "i_search = 4\n", + "Looking for paths with length: 2 for node HSPB1_S82 and HSPB1\n", + "i_search = 4\n", + "Looking for paths with length: 3 for node HSPB1_S82 and HSPB1\n", + "i_search = 4\n", + "Looking for paths with length: 4 for node HSPB1_S82 and HSPB1\n", + "looking for paths in the network with length: 0 for node HSPB1_S82 and MAPK14\n", + "looking for paths in the network with length: 1 for node HSPB1_S82 and MAPK14\n", + "looking for paths in the network with length: 2 for node HSPB1_S82 and MAPK14\n", + "looking for paths in the network with length: 3 for node HSPB1_S82 and MAPK14\n", + "looking for paths in the network with length: 4 for node HSPB1_S82 and MAPK14\n", + "looking for paths in the network with length: 5 for node HSPB1_S82 and MAPK14\n", + "looking for paths in the network with length: 6 for node HSPB1_S82 and MAPK14\n", + "looking for paths in the network with length: 7 for node HSPB1_S82 and MAPK14\n", + "looking for paths in the network with length: 8 for node HSPB1_S82 and MAPK14\n", + "looking for paths in the network with length: 9 for node HSPB1_S82 and MAPK14\n", + "looking for paths in the network with length: 10 for node HSPB1_S82 and MAPK14\n", + "i_search = 4\n", + "Looking for paths with length: 0 for node HSPB1_S82 and MAPK14\n", + "i_search = 4\n", + "Looking for paths with length: 1 for node HSPB1_S82 and MAPK14\n", + "i_search = 4\n", + "Looking for paths with length: 2 for node HSPB1_S82 and MAPK14\n", + "i_search = 4\n", + "Looking for paths with length: 3 for node HSPB1_S82 and MAPK14\n", + "i_search = 4\n", + "Looking for paths with length: 4 for node HSPB1_S82 and MAPK14\n", + "looking for paths in the network with length: 0 for node HSPB1_S82 and MAP2K1\n", + "looking for paths in the network with length: 1 for node HSPB1_S82 and MAP2K1\n", + "looking for paths in the network with length: 2 for node HSPB1_S82 and MAP2K1\n", + "looking for paths in the network with length: 3 for node HSPB1_S82 and MAP2K1\n", + "looking for paths in the network with length: 4 for node HSPB1_S82 and MAP2K1\n", + "looking for paths in the network with length: 5 for node HSPB1_S82 and MAP2K1\n", + "looking for paths in the network with length: 6 for node HSPB1_S82 and MAP2K1\n", + "looking for paths in the network with length: 7 for node HSPB1_S82 and MAP2K1\n", + "looking for paths in the network with length: 8 for node HSPB1_S82 and MAP2K1\n", + "looking for paths in the network with length: 9 for node HSPB1_S82 and MAP2K1\n", + "looking for paths in the network with length: 10 for node HSPB1_S82 and MAP2K1\n", + "i_search = 4\n", + "Looking for paths with length: 0 for node HSPB1_S82 and MAP2K1\n", + "i_search = 4\n", + "Looking for paths with length: 1 for node HSPB1_S82 and MAP2K1\n", + "i_search = 4\n", + "Looking for paths with length: 2 for node HSPB1_S82 and MAP2K1\n", + "i_search = 4\n", + "Looking for paths with length: 3 for node HSPB1_S82 and MAP2K1\n", + "i_search = 4\n", + "Looking for paths with length: 4 for node HSPB1_S82 and MAP2K1\n", + "looking for paths in the network with length: 0 for node HSPB1_S82 and RPS6KA1\n", + "looking for paths in the network with length: 1 for node HSPB1_S82 and RPS6KA1\n", + "looking for paths in the network with length: 2 for node HSPB1_S82 and RPS6KA1\n", + "looking for paths in the network with length: 3 for node HSPB1_S82 and RPS6KA1\n", + "looking for paths in the network with length: 4 for node HSPB1_S82 and RPS6KA1\n", + "looking for paths in the network with length: 5 for node HSPB1_S82 and RPS6KA1\n", + "looking for paths in the network with length: 6 for node HSPB1_S82 and RPS6KA1\n", + "looking for paths in the network with length: 7 for node HSPB1_S82 and RPS6KA1\n", + "looking for paths in the network with length: 8 for node HSPB1_S82 and RPS6KA1\n", + "looking for paths in the network with length: 9 for node HSPB1_S82 and RPS6KA1\n", + "looking for paths in the network with length: 10 for node HSPB1_S82 and RPS6KA1\n", + "i_search = 4\n", + "Looking for paths with length: 0 for node HSPB1_S82 and RPS6KA1\n", + "i_search = 4\n", + "Looking for paths with length: 1 for node HSPB1_S82 and RPS6KA1\n", + "i_search = 4\n", + "Looking for paths with length: 2 for node HSPB1_S82 and RPS6KA1\n", + "i_search = 4\n", + "Looking for paths with length: 3 for node HSPB1_S82 and RPS6KA1\n", + "i_search = 4\n", + "Looking for paths with length: 4 for node HSPB1_S82 and RPS6KA1\n", + "looking for paths in the network with length: 0 for node HSPB1_S82 and CREB1\n", + "looking for paths in the network with length: 1 for node HSPB1_S82 and CREB1\n", + "looking for paths in the network with length: 2 for node HSPB1_S82 and CREB1\n", + "looking for paths in the network with length: 3 for node HSPB1_S82 and CREB1\n", + "looking for paths in the network with length: 4 for node HSPB1_S82 and CREB1\n", + "looking for paths in the network with length: 5 for node HSPB1_S82 and CREB1\n", + "looking for paths in the network with length: 6 for node HSPB1_S82 and CREB1\n", + "looking for paths in the network with length: 7 for node HSPB1_S82 and CREB1\n", + "looking for paths in the network with length: 8 for node HSPB1_S82 and CREB1\n", + "looking for paths in the network with length: 9 for node HSPB1_S82 and CREB1\n", + "looking for paths in the network with length: 10 for node HSPB1_S82 and CREB1\n", + "i_search = 4\n", + "Looking for paths with length: 0 for node HSPB1_S82 and CREB1\n", + "i_search = 4\n", + "Looking for paths with length: 1 for node HSPB1_S82 and CREB1\n", + "i_search = 4\n", + "Looking for paths with length: 2 for node HSPB1_S82 and CREB1\n", + "i_search = 4\n", + "Looking for paths with length: 3 for node HSPB1_S82 and CREB1\n", + "i_search = 4\n", + "Looking for paths with length: 4 for node HSPB1_S82 and CREB1\n", + "looking for paths in the network with length: 0 for node HSPB1_S82 and NFKBIA\n", + "looking for paths in the network with length: 1 for node HSPB1_S82 and NFKBIA\n", + "looking for paths in the network with length: 2 for node HSPB1_S82 and NFKBIA\n", + "looking for paths in the network with length: 3 for node HSPB1_S82 and NFKBIA\n", + "looking for paths in the network with length: 4 for node HSPB1_S82 and NFKBIA\n", + "looking for paths in the network with length: 5 for node HSPB1_S82 and NFKBIA\n", + "looking for paths in the network with length: 6 for node HSPB1_S82 and NFKBIA\n", + "looking for paths in the network with length: 7 for node HSPB1_S82 and NFKBIA\n", + "looking for paths in the network with length: 8 for node HSPB1_S82 and NFKBIA\n", + "looking for paths in the network with length: 9 for node HSPB1_S82 and NFKBIA\n", + "looking for paths in the network with length: 10 for node HSPB1_S82 and NFKBIA\n", + "i_search = 4\n", + "Looking for paths with length: 0 for node HSPB1_S82 and NFKBIA\n", + "i_search = 4\n", + "Looking for paths with length: 1 for node HSPB1_S82 and NFKBIA\n", + "i_search = 4\n", + "Looking for paths with length: 2 for node HSPB1_S82 and NFKBIA\n", + "i_search = 4\n", + "Looking for paths with length: 3 for node HSPB1_S82 and NFKBIA\n", + "i_search = 4\n", + "Looking for paths with length: 4 for node HSPB1_S82 and NFKBIA\n", + "looking for paths in the network with length: 0 for node HSPB1_S82 and MTOR\n", + "looking for paths in the network with length: 1 for node HSPB1_S82 and MTOR\n", + "looking for paths in the network with length: 2 for node HSPB1_S82 and MTOR\n", + "looking for paths in the network with length: 3 for node HSPB1_S82 and MTOR\n", + "looking for paths in the network with length: 4 for node HSPB1_S82 and MTOR\n", + "looking for paths in the network with length: 5 for node HSPB1_S82 and MTOR\n", + "looking for paths in the network with length: 6 for node HSPB1_S82 and MTOR\n", + "looking for paths in the network with length: 7 for node HSPB1_S82 and MTOR\n", + "looking for paths in the network with length: 8 for node HSPB1_S82 and MTOR\n", + "looking for paths in the network with length: 9 for node HSPB1_S82 and MTOR\n", + "looking for paths in the network with length: 10 for node HSPB1_S82 and MTOR\n", + "i_search = 4\n", + "Looking for paths with length: 0 for node HSPB1_S82 and MTOR\n", + "i_search = 4\n", + "Looking for paths with length: 1 for node HSPB1_S82 and MTOR\n", + "i_search = 4\n", + "Looking for paths with length: 2 for node HSPB1_S82 and MTOR\n", + "i_search = 4\n", + "Looking for paths with length: 3 for node HSPB1_S82 and MTOR\n", + "i_search = 4\n", + "Looking for paths with length: 4 for node HSPB1_S82 and MTOR\n", + "looking for paths in the network with length: 0 for node HSPB1_S82 and JUN\n", + "looking for paths in the network with length: 1 for node HSPB1_S82 and JUN\n", + "looking for paths in the network with length: 2 for node HSPB1_S82 and JUN\n", + "looking for paths in the network with length: 3 for node HSPB1_S82 and JUN\n", + "looking for paths in the network with length: 4 for node HSPB1_S82 and JUN\n", + "looking for paths in the network with length: 5 for node HSPB1_S82 and JUN\n", + "looking for paths in the network with length: 6 for node HSPB1_S82 and JUN\n", + "looking for paths in the network with length: 7 for node HSPB1_S82 and JUN\n", + "looking for paths in the network with length: 8 for node HSPB1_S82 and JUN\n", + "looking for paths in the network with length: 9 for node HSPB1_S82 and JUN\n", + "looking for paths in the network with length: 10 for node HSPB1_S82 and JUN\n", + "i_search = 4\n", + "Looking for paths with length: 0 for node HSPB1_S82 and JUN\n", + "i_search = 4\n", + "Looking for paths with length: 1 for node HSPB1_S82 and JUN\n", + "i_search = 4\n", + "Looking for paths with length: 2 for node HSPB1_S82 and JUN\n", + "i_search = 4\n", + "Looking for paths with length: 3 for node HSPB1_S82 and JUN\n", + "i_search = 4\n", + "Looking for paths with length: 4 for node HSPB1_S82 and JUN\n", + "looking for paths in the network with length: 0 for node HSPB1_S82 and EGFR\n", + "looking for paths in the network with length: 1 for node HSPB1_S82 and EGFR\n", + "looking for paths in the network with length: 2 for node HSPB1_S82 and EGFR\n", + "looking for paths in the network with length: 3 for node HSPB1_S82 and EGFR\n", + "looking for paths in the network with length: 4 for node HSPB1_S82 and EGFR\n", + "looking for paths in the network with length: 5 for node HSPB1_S82 and EGFR\n", + "looking for paths in the network with length: 6 for node HSPB1_S82 and EGFR\n", + "looking for paths in the network with length: 7 for node HSPB1_S82 and EGFR\n", + "looking for paths in the network with length: 8 for node HSPB1_S82 and EGFR\n", + "looking for paths in the network with length: 9 for node HSPB1_S82 and EGFR\n", + "looking for paths in the network with length: 10 for node HSPB1_S82 and EGFR\n", + "i_search = 4\n", + "Looking for paths with length: 0 for node HSPB1_S82 and EGFR\n", + "i_search = 4\n", + "Looking for paths with length: 1 for node HSPB1_S82 and EGFR\n", + "i_search = 4\n", + "Looking for paths with length: 2 for node HSPB1_S82 and EGFR\n", + "i_search = 4\n", + "Looking for paths with length: 3 for node HSPB1_S82 and EGFR\n", + "i_search = 4\n", + "Looking for paths with length: 4 for node HSPB1_S82 and EGFR\n", + "looking for paths in the network with length: 0 for node HSPB1_S82 and MAPK3\n", + "looking for paths in the network with length: 1 for node HSPB1_S82 and MAPK3\n", + "looking for paths in the network with length: 2 for node HSPB1_S82 and MAPK3\n", + "looking for paths in the network with length: 3 for node HSPB1_S82 and MAPK3\n", + "looking for paths in the network with length: 4 for node HSPB1_S82 and MAPK3\n", + "looking for paths in the network with length: 5 for node HSPB1_S82 and MAPK3\n", + "looking for paths in the network with length: 6 for node HSPB1_S82 and MAPK3\n", + "looking for paths in the network with length: 7 for node HSPB1_S82 and MAPK3\n", + "looking for paths in the network with length: 8 for node HSPB1_S82 and MAPK3\n", + "looking for paths in the network with length: 9 for node HSPB1_S82 and MAPK3\n", + "looking for paths in the network with length: 10 for node HSPB1_S82 and MAPK3\n", + "i_search = 4\n", + "Looking for paths with length: 0 for node HSPB1_S82 and MAPK3\n", + "i_search = 4\n", + "Looking for paths with length: 1 for node HSPB1_S82 and MAPK3\n", + "i_search = 4\n", + "Looking for paths with length: 2 for node HSPB1_S82 and MAPK3\n", + "i_search = 4\n", + "Looking for paths with length: 3 for node HSPB1_S82 and MAPK3\n", + "i_search = 4\n", + "Looking for paths with length: 4 for node HSPB1_S82 and MAPK3\n", + "looking for paths in the network with length: 0 for node HSPB1_S82 and PTPN11\n", + "looking for paths in the network with length: 1 for node HSPB1_S82 and PTPN11\n", + "looking for paths in the network with length: 2 for node HSPB1_S82 and PTPN11\n", + "looking for paths in the network with length: 3 for node HSPB1_S82 and PTPN11\n", + "looking for paths in the network with length: 4 for node HSPB1_S82 and PTPN11\n", + "looking for paths in the network with length: 5 for node HSPB1_S82 and PTPN11\n", + "looking for paths in the network with length: 6 for node HSPB1_S82 and PTPN11\n", + "looking for paths in the network with length: 7 for node HSPB1_S82 and PTPN11\n", + "looking for paths in the network with length: 8 for node HSPB1_S82 and PTPN11\n", + "looking for paths in the network with length: 9 for node HSPB1_S82 and PTPN11\n", + "looking for paths in the network with length: 10 for node HSPB1_S82 and PTPN11\n", + "i_search = 4\n", + "Looking for paths with length: 0 for node HSPB1_S82 and PTPN11\n", + "i_search = 4\n", + "Looking for paths with length: 1 for node HSPB1_S82 and PTPN11\n", + "i_search = 4\n", + "Looking for paths with length: 2 for node HSPB1_S82 and PTPN11\n", + "i_search = 4\n", + "Looking for paths with length: 3 for node HSPB1_S82 and PTPN11\n", + "i_search = 4\n", + "Looking for paths with length: 4 for node HSPB1_S82 and PTPN11\n", + "looking for paths in the network with length: 0 for node HSPB1_S82 and STAT3\n", + "looking for paths in the network with length: 1 for node HSPB1_S82 and STAT3\n", + "looking for paths in the network with length: 2 for node HSPB1_S82 and STAT3\n", + "looking for paths in the network with length: 3 for node HSPB1_S82 and STAT3\n", + "looking for paths in the network with length: 4 for node HSPB1_S82 and STAT3\n", + "looking for paths in the network with length: 5 for node HSPB1_S82 and STAT3\n", + "looking for paths in the network with length: 6 for node HSPB1_S82 and STAT3\n", + "looking for paths in the network with length: 7 for node HSPB1_S82 and STAT3\n", + "looking for paths in the network with length: 8 for node HSPB1_S82 and STAT3\n", + "looking for paths in the network with length: 9 for node HSPB1_S82 and STAT3\n", + "looking for paths in the network with length: 10 for node HSPB1_S82 and STAT3\n", + "i_search = 4\n", + "Looking for paths with length: 0 for node HSPB1_S82 and STAT3\n", + "i_search = 4\n", + "Looking for paths with length: 1 for node HSPB1_S82 and STAT3\n", + "i_search = 4\n", + "Looking for paths with length: 2 for node HSPB1_S82 and STAT3\n", + "i_search = 4\n", + "Looking for paths with length: 3 for node HSPB1_S82 and STAT3\n", + "i_search = 4\n", + "Looking for paths with length: 4 for node HSPB1_S82 and STAT3\n", + "looking for paths in the network with length: 0 for node HSPB1_S82 and CHEK2\n", + "looking for paths in the network with length: 1 for node HSPB1_S82 and CHEK2\n", + "looking for paths in the network with length: 2 for node HSPB1_S82 and CHEK2\n", + "looking for paths in the network with length: 3 for node HSPB1_S82 and CHEK2\n", + "looking for paths in the network with length: 4 for node HSPB1_S82 and CHEK2\n", + "looking for paths in the network with length: 5 for node HSPB1_S82 and CHEK2\n", + "looking for paths in the network with length: 6 for node HSPB1_S82 and CHEK2\n", + "looking for paths in the network with length: 7 for node HSPB1_S82 and CHEK2\n", + "looking for paths in the network with length: 8 for node HSPB1_S82 and CHEK2\n", + "looking for paths in the network with length: 9 for node HSPB1_S82 and CHEK2\n", + "looking for paths in the network with length: 10 for node HSPB1_S82 and CHEK2\n", + "i_search = 4\n", + "Looking for paths with length: 0 for node HSPB1_S82 and CHEK2\n", + "i_search = 4\n", + "Looking for paths with length: 1 for node HSPB1_S82 and CHEK2\n", + "i_search = 4\n", + "Looking for paths with length: 2 for node HSPB1_S82 and CHEK2\n", + "i_search = 4\n", + "Looking for paths with length: 3 for node HSPB1_S82 and CHEK2\n", + "i_search = 4\n", + "Looking for paths with length: 4 for node HSPB1_S82 and CHEK2\n", + "looking for paths in the network with length: 0 for node HSPB1_S82 and RELA\n", + "looking for paths in the network with length: 1 for node HSPB1_S82 and RELA\n", + "looking for paths in the network with length: 2 for node HSPB1_S82 and RELA\n", + "looking for paths in the network with length: 3 for node HSPB1_S82 and RELA\n", + "looking for paths in the network with length: 4 for node HSPB1_S82 and RELA\n", + "looking for paths in the network with length: 5 for node HSPB1_S82 and RELA\n", + "looking for paths in the network with length: 6 for node HSPB1_S82 and RELA\n", + "looking for paths in the network with length: 7 for node HSPB1_S82 and RELA\n", + "looking for paths in the network with length: 8 for node HSPB1_S82 and RELA\n", + "looking for paths in the network with length: 9 for node HSPB1_S82 and RELA\n", + "looking for paths in the network with length: 10 for node HSPB1_S82 and RELA\n", + "i_search = 4\n", + "Looking for paths with length: 0 for node HSPB1_S82 and RELA\n", + "i_search = 4\n", + "Looking for paths with length: 1 for node HSPB1_S82 and RELA\n", + "i_search = 4\n", + "Looking for paths with length: 2 for node HSPB1_S82 and RELA\n", + "i_search = 4\n", + "Looking for paths with length: 3 for node HSPB1_S82 and RELA\n", + "i_search = 4\n", + "Looking for paths with length: 4 for node HSPB1_S82 and RELA\n", + "looking for paths in the network with length: 0 for node HSPB1_S82 and MARCKS\n", + "looking for paths in the network with length: 1 for node HSPB1_S82 and MARCKS\n", + "looking for paths in the network with length: 2 for node HSPB1_S82 and MARCKS\n", + "looking for paths in the network with length: 3 for node HSPB1_S82 and MARCKS\n", + "looking for paths in the network with length: 4 for node HSPB1_S82 and MARCKS\n", + "looking for paths in the network with length: 5 for node HSPB1_S82 and MARCKS\n", + "looking for paths in the network with length: 6 for node HSPB1_S82 and MARCKS\n", + "looking for paths in the network with length: 7 for node HSPB1_S82 and MARCKS\n", + "looking for paths in the network with length: 8 for node HSPB1_S82 and MARCKS\n", + "looking for paths in the network with length: 9 for node HSPB1_S82 and MARCKS\n", + "looking for paths in the network with length: 10 for node HSPB1_S82 and MARCKS\n", + "i_search = 4\n", + "Looking for paths with length: 0 for node HSPB1_S82 and MARCKS\n", + "i_search = 4\n", + "Looking for paths with length: 1 for node HSPB1_S82 and MARCKS\n", + "i_search = 4\n", + "Looking for paths with length: 2 for node HSPB1_S82 and MARCKS\n", + "i_search = 4\n", + "Looking for paths with length: 3 for node HSPB1_S82 and MARCKS\n", + "i_search = 4\n", + "Looking for paths with length: 4 for node HSPB1_S82 and MARCKS\n", + "looking for paths in the network with length: 0 for node MAPK14_T180 and MAPK14_Y182\n", + "looking for paths in the network with length: 1 for node MAPK14_T180 and MAPK14_Y182\n", + "looking for paths in the network with length: 2 for node MAPK14_T180 and MAPK14_Y182\n", + "looking for paths in the network with length: 3 for node MAPK14_T180 and MAPK14_Y182\n", + "looking for paths in the network with length: 4 for node MAPK14_T180 and MAPK14_Y182\n", + "looking for paths in the network with length: 5 for node MAPK14_T180 and MAPK14_Y182\n", + "looking for paths in the network with length: 6 for node MAPK14_T180 and MAPK14_Y182\n", + "looking for paths in the network with length: 7 for node MAPK14_T180 and MAPK14_Y182\n", + "looking for paths in the network with length: 8 for node MAPK14_T180 and MAPK14_Y182\n", + "Found a path!\n", + "[['MAPK14_T180', 'MAP3K5', 'MAP3K5_S83', 'AKT1', 'AKT1_S473', 'MAPKAPK2', 'MAPKAPK2_T334', 'MAPK14', 'MAPK14_Y182'], ['MAPK14_T180', 'MAP3K5', 'MAP3K5_S83', 'AKT1', 'AKT1_S473', 'MAPKAPK2', 'MAPKAPK2_S272', 'MAPK14', 'MAPK14_Y182'], ['MAPK14_T180', 'MAP3K5', 'MAP3K5_S83', 'AKT1', 'AKT1_S473', 'MAPKAPK2', 'MAPKAPK2_T222', 'MAPK14', 'MAPK14_Y182'], ['MAPK14_T180', 'MAP2K4', 'MAP2K4_S80', 'AKT1', 'AKT1_S473', 'MAPKAPK2', 'MAPKAPK2_T334', 'MAPK14', 'MAPK14_Y182'], ['MAPK14_T180', 'MAP2K4', 'MAP2K4_S80', 'AKT1', 'AKT1_S473', 'MAPKAPK2', 'MAPKAPK2_S272', 'MAPK14', 'MAPK14_Y182'], ['MAPK14_T180', 'MAP2K4', 'MAP2K4_S80', 'AKT1', 'AKT1_S473', 'MAPKAPK2', 'MAPKAPK2_T222', 'MAPK14', 'MAPK14_Y182']]\n", + "looking for paths in the network with length: 0 for node MAPK14_T180 and MAP2K1_S218\n", + "looking for paths in the network with length: 1 for node MAPK14_T180 and MAP2K1_S218\n", + "looking for paths in the network with length: 2 for node MAPK14_T180 and MAP2K1_S218\n", + "looking for paths in the network with length: 3 for node MAPK14_T180 and MAP2K1_S218\n", + "looking for paths in the network with length: 4 for node MAPK14_T180 and MAP2K1_S218\n", + "looking for paths in the network with length: 5 for node MAPK14_T180 and MAP2K1_S218\n", + "looking for paths in the network with length: 6 for node MAPK14_T180 and MAP2K1_S218\n", + "looking for paths in the network with length: 7 for node MAPK14_T180 and MAP2K1_S218\n", + "looking for paths in the network with length: 8 for node MAPK14_T180 and MAP2K1_S218\n", + "Found a path!\n", + "[['MAPK14_T180', 'MAPK14', 'MAPKAPK2_S272', 'MAPKAPK2', 'AKT1_S473', 'AKT1', 'RAF1_S259', 'RAF1', 'MAP2K1_S218'], ['MAPK14_T180', 'MAPK14', 'MAPKAPK2_S272', 'MAPKAPK2', 'AKT1_S473', 'AKT1', 'BRAF_S429', 'BRAF', 'MAP2K1_S218'], ['MAPK14_T180', 'MAPK14', 'MAPKAPK2_S272', 'MAPKAPK2', 'AKT1_S473', 'AKT1', 'BRAF_S365', 'BRAF', 'MAP2K1_S218'], ['MAPK14_T180', 'MAPK14', 'MAPKAPK2_T222', 'MAPKAPK2', 'AKT1_S473', 'AKT1', 'RAF1_S259', 'RAF1', 'MAP2K1_S218'], ['MAPK14_T180', 'MAPK14', 'MAPKAPK2_T222', 'MAPKAPK2', 'AKT1_S473', 'AKT1', 'BRAF_S429', 'BRAF', 'MAP2K1_S218'], ['MAPK14_T180', 'MAPK14', 'MAPKAPK2_T222', 'MAPKAPK2', 'AKT1_S473', 'AKT1', 'BRAF_S365', 'BRAF', 'MAP2K1_S218'], ['MAPK14_T180', 'MAPK14', 'MAPKAPK2_T334', 'MAPKAPK2', 'AKT1_S473', 'AKT1', 'RAF1_S259', 'RAF1', 'MAP2K1_S218'], ['MAPK14_T180', 'MAPK14', 'MAPKAPK2_T334', 'MAPKAPK2', 'AKT1_S473', 'AKT1', 'BRAF_S429', 'BRAF', 'MAP2K1_S218'], ['MAPK14_T180', 'MAPK14', 'MAPKAPK2_T334', 'MAPKAPK2', 'AKT1_S473', 'AKT1', 'BRAF_S365', 'BRAF', 'MAP2K1_S218']]\n", + "looking for paths in the network with length: 0 for node MAPK14_T180 and MAP2K1_S222\n", + "looking for paths in the network with length: 1 for node MAPK14_T180 and MAP2K1_S222\n", + "looking for paths in the network with length: 2 for node MAPK14_T180 and MAP2K1_S222\n", + "looking for paths in the network with length: 3 for node MAPK14_T180 and MAP2K1_S222\n", + "looking for paths in the network with length: 4 for node MAPK14_T180 and MAP2K1_S222\n", + "looking for paths in the network with length: 5 for node MAPK14_T180 and MAP2K1_S222\n", + "looking for paths in the network with length: 6 for node MAPK14_T180 and MAP2K1_S222\n", + "looking for paths in the network with length: 7 for node MAPK14_T180 and MAP2K1_S222\n", + "looking for paths in the network with length: 8 for node MAPK14_T180 and MAP2K1_S222\n", + "Found a path!\n", + "[['MAPK14_T180', 'MAPK14', 'MAPKAPK2_S272', 'MAPKAPK2', 'AKT1_S473', 'AKT1', 'RAF1_S259', 'RAF1', 'MAP2K1_S222'], ['MAPK14_T180', 'MAPK14', 'MAPKAPK2_S272', 'MAPKAPK2', 'AKT1_S473', 'AKT1', 'BRAF_S429', 'BRAF', 'MAP2K1_S222'], ['MAPK14_T180', 'MAPK14', 'MAPKAPK2_S272', 'MAPKAPK2', 'AKT1_S473', 'AKT1', 'BRAF_S365', 'BRAF', 'MAP2K1_S222'], ['MAPK14_T180', 'MAPK14', 'MAPKAPK2_T222', 'MAPKAPK2', 'AKT1_S473', 'AKT1', 'RAF1_S259', 'RAF1', 'MAP2K1_S222'], ['MAPK14_T180', 'MAPK14', 'MAPKAPK2_T222', 'MAPKAPK2', 'AKT1_S473', 'AKT1', 'BRAF_S429', 'BRAF', 'MAP2K1_S222'], ['MAPK14_T180', 'MAPK14', 'MAPKAPK2_T222', 'MAPKAPK2', 'AKT1_S473', 'AKT1', 'BRAF_S365', 'BRAF', 'MAP2K1_S222'], ['MAPK14_T180', 'MAPK14', 'MAPKAPK2_T334', 'MAPKAPK2', 'AKT1_S473', 'AKT1', 'RAF1_S259', 'RAF1', 'MAP2K1_S222'], ['MAPK14_T180', 'MAPK14', 'MAPKAPK2_T334', 'MAPKAPK2', 'AKT1_S473', 'AKT1', 'BRAF_S429', 'BRAF', 'MAP2K1_S222'], ['MAPK14_T180', 'MAPK14', 'MAPKAPK2_T334', 'MAPKAPK2', 'AKT1_S473', 'AKT1', 'BRAF_S365', 'BRAF', 'MAP2K1_S222']]\n", + "looking for paths in the network with length: 0 for node MAPK14_T180 and RPS6KA1_S380\n", + "looking for paths in the network with length: 1 for node MAPK14_T180 and RPS6KA1_S380\n", + "looking for paths in the network with length: 2 for node MAPK14_T180 and RPS6KA1_S380\n", + "looking for paths in the network with length: 3 for node MAPK14_T180 and RPS6KA1_S380\n", + "looking for paths in the network with length: 4 for node MAPK14_T180 and RPS6KA1_S380\n", + "looking for paths in the network with length: 5 for node MAPK14_T180 and RPS6KA1_S380\n", + "looking for paths in the network with length: 6 for node MAPK14_T180 and RPS6KA1_S380\n", + "looking for paths in the network with length: 7 for node MAPK14_T180 and RPS6KA1_S380\n", + "looking for paths in the network with length: 8 for node MAPK14_T180 and RPS6KA1_S380\n", + "looking for paths in the network with length: 9 for node MAPK14_T180 and RPS6KA1_S380\n", + "looking for paths in the network with length: 10 for node MAPK14_T180 and RPS6KA1_S380\n", + "i_search = 4\n", + "Looking for paths with length: 0 for node MAPK14_T180 and RPS6KA1_S380\n", + "i_search = 4\n", + "Looking for paths with length: 1 for node MAPK14_T180 and RPS6KA1_S380\n", + "i_search = 4\n", + "Looking for paths with length: 2 for node MAPK14_T180 and RPS6KA1_S380\n", + "i_search = 4\n", + "Looking for paths with length: 3 for node MAPK14_T180 and RPS6KA1_S380\n", + "i_search = 4\n", + "Looking for paths with length: 4 for node MAPK14_T180 and RPS6KA1_S380\n", + "[['MAPK14_T180', 'MAPK14', 'MAPKAPK2_S272', 'MAPKAPK2', 'RPS6KA1_S380'], ['MAPK14_T180', 'MAPK14', 'MAPKAPK2_T222', 'MAPKAPK2', 'RPS6KA1_S380'], ['MAPK14_T180', 'MAPK14', 'MAPKAPK2_T334', 'MAPKAPK2', 'RPS6KA1_S380']]\n", + "MAPK14_T180 MAPK14\n", + "MAPK14 MAPKAPK2_S272\n", + "MAPKAPK2_S272 MAPKAPK2\n", + "MAPKAPK2 RPS6KA1_S380\n", + "MAPK14_T180 MAPK14\n", + "MAPK14 MAPKAPK2_T222\n", + "MAPKAPK2_T222 MAPKAPK2\n", + "MAPKAPK2 RPS6KA1_S380\n", + "MAPK14_T180 MAPK14\n", + "MAPK14 MAPKAPK2_T334\n", + "MAPKAPK2_T334 MAPKAPK2\n", + "MAPKAPK2 RPS6KA1_S380\n", + "looking for paths in the network with length: 0 for node MAPK14_T180 and CREB1_S133\n", + "looking for paths in the network with length: 1 for node MAPK14_T180 and CREB1_S133\n", + "looking for paths in the network with length: 2 for node MAPK14_T180 and CREB1_S133\n", + "looking for paths in the network with length: 3 for node MAPK14_T180 and CREB1_S133\n", + "looking for paths in the network with length: 4 for node MAPK14_T180 and CREB1_S133\n", + "looking for paths in the network with length: 5 for node MAPK14_T180 and CREB1_S133\n", + "looking for paths in the network with length: 6 for node MAPK14_T180 and CREB1_S133\n", + "looking for paths in the network with length: 7 for node MAPK14_T180 and CREB1_S133\n", + "looking for paths in the network with length: 8 for node MAPK14_T180 and CREB1_S133\n", + "looking for paths in the network with length: 9 for node MAPK14_T180 and CREB1_S133\n", + "looking for paths in the network with length: 10 for node MAPK14_T180 and CREB1_S133\n", + "i_search = 4\n", + "Looking for paths with length: 0 for node MAPK14_T180 and CREB1_S133\n", + "i_search = 4\n", + "Looking for paths with length: 1 for node MAPK14_T180 and CREB1_S133\n", + "i_search = 4\n", + "Looking for paths with length: 2 for node MAPK14_T180 and CREB1_S133\n", + "i_search = 4\n", + "Looking for paths with length: 3 for node MAPK14_T180 and CREB1_S133\n", + "i_search = 4\n", + "Looking for paths with length: 4 for node MAPK14_T180 and CREB1_S133\n", + "looking for paths in the network with length: 0 for node MAPK14_T180 and NFKBIA_S32\n", + "looking for paths in the network with length: 1 for node MAPK14_T180 and NFKBIA_S32\n", + "looking for paths in the network with length: 2 for node MAPK14_T180 and NFKBIA_S32\n", + "looking for paths in the network with length: 3 for node MAPK14_T180 and NFKBIA_S32\n", + "looking for paths in the network with length: 4 for node MAPK14_T180 and NFKBIA_S32\n", + "looking for paths in the network with length: 5 for node MAPK14_T180 and NFKBIA_S32\n", + "looking for paths in the network with length: 6 for node MAPK14_T180 and NFKBIA_S32\n", + "looking for paths in the network with length: 7 for node MAPK14_T180 and NFKBIA_S32\n", + "looking for paths in the network with length: 8 for node MAPK14_T180 and NFKBIA_S32\n", + "Found a path!\n", + "[['MAPK14_T180', 'MAPK14', 'MAPKAPK2_S272', 'MAPKAPK2', 'AKT1_S473', 'AKT1', 'RPS6KA3_S19', 'RPS6KA3', 'NFKBIA_S32'], ['MAPK14_T180', 'MAPK14', 'MAPKAPK2_S272', 'MAPKAPK2', 'AKT1_S473', 'AKT1', 'CHUK_T23', 'CHUK', 'NFKBIA_S32'], ['MAPK14_T180', 'MAPK14', 'MAPKAPK2_T222', 'MAPKAPK2', 'AKT1_S473', 'AKT1', 'RPS6KA3_S19', 'RPS6KA3', 'NFKBIA_S32'], ['MAPK14_T180', 'MAPK14', 'MAPKAPK2_T222', 'MAPKAPK2', 'AKT1_S473', 'AKT1', 'CHUK_T23', 'CHUK', 'NFKBIA_S32'], ['MAPK14_T180', 'MAPK14', 'MAPKAPK2_T334', 'MAPKAPK2', 'AKT1_S473', 'AKT1', 'RPS6KA3_S19', 'RPS6KA3', 'NFKBIA_S32'], ['MAPK14_T180', 'MAPK14', 'MAPKAPK2_T334', 'MAPKAPK2', 'AKT1_S473', 'AKT1', 'CHUK_T23', 'CHUK', 'NFKBIA_S32']]\n", + "looking for paths in the network with length: 0 for node MAPK14_T180 and NFKBIA_S36\n", + "looking for paths in the network with length: 1 for node MAPK14_T180 and NFKBIA_S36\n", + "looking for paths in the network with length: 2 for node MAPK14_T180 and NFKBIA_S36\n", + "looking for paths in the network with length: 3 for node MAPK14_T180 and NFKBIA_S36\n", + "looking for paths in the network with length: 4 for node MAPK14_T180 and NFKBIA_S36\n", + "looking for paths in the network with length: 5 for node MAPK14_T180 and NFKBIA_S36\n", + "looking for paths in the network with length: 6 for node MAPK14_T180 and NFKBIA_S36\n", + "looking for paths in the network with length: 7 for node MAPK14_T180 and NFKBIA_S36\n", + "looking for paths in the network with length: 8 for node MAPK14_T180 and NFKBIA_S36\n", + "Found a path!\n", + "[['MAPK14_T180', 'MAPK14', 'MAPKAPK2_S272', 'MAPKAPK2', 'AKT1_S473', 'AKT1', 'CHUK_T23', 'CHUK', 'NFKBIA_S36'], ['MAPK14_T180', 'MAPK14', 'MAPKAPK2_T222', 'MAPKAPK2', 'AKT1_S473', 'AKT1', 'CHUK_T23', 'CHUK', 'NFKBIA_S36'], ['MAPK14_T180', 'MAPK14', 'MAPKAPK2_T334', 'MAPKAPK2', 'AKT1_S473', 'AKT1', 'CHUK_T23', 'CHUK', 'NFKBIA_S36']]\n", + "looking for paths in the network with length: 0 for node MAPK14_T180 and MTOR_S2448\n", + "looking for paths in the network with length: 1 for node MAPK14_T180 and MTOR_S2448\n", + "looking for paths in the network with length: 2 for node MAPK14_T180 and MTOR_S2448\n", + "looking for paths in the network with length: 3 for node MAPK14_T180 and MTOR_S2448\n", + "looking for paths in the network with length: 4 for node MAPK14_T180 and MTOR_S2448\n", + "looking for paths in the network with length: 5 for node MAPK14_T180 and MTOR_S2448\n", + "looking for paths in the network with length: 6 for node MAPK14_T180 and MTOR_S2448\n", + "Found a path!\n", + "[['MAPK14_T180', 'MAPK14', 'MAPKAPK2_S272', 'MAPKAPK2', 'AKT1_S473', 'AKT1', 'MTOR_S2448'], ['MAPK14_T180', 'MAPK14', 'MAPKAPK2_T222', 'MAPKAPK2', 'AKT1_S473', 'AKT1', 'MTOR_S2448'], ['MAPK14_T180', 'MAPK14', 'MAPKAPK2_T334', 'MAPKAPK2', 'AKT1_S473', 'AKT1', 'MTOR_S2448']]\n", + "looking for paths in the network with length: 0 for node MAPK14_T180 and JUN_S63\n", + "looking for paths in the network with length: 1 for node MAPK14_T180 and JUN_S63\n", + "looking for paths in the network with length: 2 for node MAPK14_T180 and JUN_S63\n", + "looking for paths in the network with length: 3 for node MAPK14_T180 and JUN_S63\n", + "looking for paths in the network with length: 4 for node MAPK14_T180 and JUN_S63\n", + "looking for paths in the network with length: 5 for node MAPK14_T180 and JUN_S63\n", + "looking for paths in the network with length: 6 for node MAPK14_T180 and JUN_S63\n", + "looking for paths in the network with length: 7 for node MAPK14_T180 and JUN_S63\n", + "looking for paths in the network with length: 8 for node MAPK14_T180 and JUN_S63\n", + "looking for paths in the network with length: 9 for node MAPK14_T180 and JUN_S63\n", + "looking for paths in the network with length: 10 for node MAPK14_T180 and JUN_S63\n", + "i_search = 4\n", + "Looking for paths with length: 0 for node MAPK14_T180 and JUN_S63\n", + "i_search = 4\n", + "Looking for paths with length: 1 for node MAPK14_T180 and JUN_S63\n", + "i_search = 4\n", + "Looking for paths with length: 2 for node MAPK14_T180 and JUN_S63\n", + "i_search = 4\n", + "Looking for paths with length: 3 for node MAPK14_T180 and JUN_S63\n", + "i_search = 4\n", + "Looking for paths with length: 4 for node MAPK14_T180 and JUN_S63\n", + "looking for paths in the network with length: 0 for node MAPK14_T180 and EGFR_Y1068\n", + "looking for paths in the network with length: 1 for node MAPK14_T180 and EGFR_Y1068\n", + "looking for paths in the network with length: 2 for node MAPK14_T180 and EGFR_Y1068\n", + "looking for paths in the network with length: 3 for node MAPK14_T180 and EGFR_Y1068\n", + "looking for paths in the network with length: 4 for node MAPK14_T180 and EGFR_Y1068\n", + "looking for paths in the network with length: 5 for node MAPK14_T180 and EGFR_Y1068\n", + "looking for paths in the network with length: 6 for node MAPK14_T180 and EGFR_Y1068\n", + "looking for paths in the network with length: 7 for node MAPK14_T180 and EGFR_Y1068\n", + "looking for paths in the network with length: 8 for node MAPK14_T180 and EGFR_Y1068\n", + "looking for paths in the network with length: 9 for node MAPK14_T180 and EGFR_Y1068\n", + "looking for paths in the network with length: 10 for node MAPK14_T180 and EGFR_Y1068\n", + "i_search = 4\n", + "Looking for paths with length: 0 for node MAPK14_T180 and EGFR_Y1068\n", + "i_search = 4\n", + "Looking for paths with length: 1 for node MAPK14_T180 and EGFR_Y1068\n", + "i_search = 4\n", + "Looking for paths with length: 2 for node MAPK14_T180 and EGFR_Y1068\n", + "i_search = 4\n", + "Looking for paths with length: 3 for node MAPK14_T180 and EGFR_Y1068\n", + "i_search = 4\n", + "Looking for paths with length: 4 for node MAPK14_T180 and EGFR_Y1068\n", + "looking for paths in the network with length: 0 for node MAPK14_T180 and MAPK3_T202\n", + "looking for paths in the network with length: 1 for node MAPK14_T180 and MAPK3_T202\n", + "looking for paths in the network with length: 2 for node MAPK14_T180 and MAPK3_T202\n", + "looking for paths in the network with length: 3 for node MAPK14_T180 and MAPK3_T202\n", + "looking for paths in the network with length: 4 for node MAPK14_T180 and MAPK3_T202\n", + "looking for paths in the network with length: 5 for node MAPK14_T180 and MAPK3_T202\n", + "looking for paths in the network with length: 6 for node MAPK14_T180 and MAPK3_T202\n", + "looking for paths in the network with length: 7 for node MAPK14_T180 and MAPK3_T202\n", + "looking for paths in the network with length: 8 for node MAPK14_T180 and MAPK3_T202\n", + "looking for paths in the network with length: 9 for node MAPK14_T180 and MAPK3_T202\n", + "looking for paths in the network with length: 10 for node MAPK14_T180 and MAPK3_T202\n", + "Found a path!\n", + "[['MAPK14_T180', 'MAPK14', 'MAPKAPK2_S272', 'MAPKAPK2', 'AKT1_S473', 'AKT1', 'RAF1_S259', 'RAF1', 'MAP2K1_S222', 'MAP2K1', 'MAPK3_T202'], ['MAPK14_T180', 'MAPK14', 'MAPKAPK2_S272', 'MAPKAPK2', 'AKT1_S473', 'AKT1', 'RAF1_S259', 'RAF1', 'MAP2K1_S218', 'MAP2K1', 'MAPK3_T202'], ['MAPK14_T180', 'MAPK14', 'MAPKAPK2_S272', 'MAPKAPK2', 'AKT1_S473', 'AKT1', 'BRAF_S429', 'BRAF', 'MAP2K1_S222', 'MAP2K1', 'MAPK3_T202'], ['MAPK14_T180', 'MAPK14', 'MAPKAPK2_S272', 'MAPKAPK2', 'AKT1_S473', 'AKT1', 'BRAF_S429', 'BRAF', 'MAP2K1_S218', 'MAP2K1', 'MAPK3_T202'], ['MAPK14_T180', 'MAPK14', 'MAPKAPK2_S272', 'MAPKAPK2', 'AKT1_S473', 'AKT1', 'BRAF_S365', 'BRAF', 'MAP2K1_S222', 'MAP2K1', 'MAPK3_T202'], ['MAPK14_T180', 'MAPK14', 'MAPKAPK2_S272', 'MAPKAPK2', 'AKT1_S473', 'AKT1', 'BRAF_S365', 'BRAF', 'MAP2K1_S218', 'MAP2K1', 'MAPK3_T202'], ['MAPK14_T180', 'MAPK14', 'MAPKAPK2_T222', 'MAPKAPK2', 'AKT1_S473', 'AKT1', 'RAF1_S259', 'RAF1', 'MAP2K1_S222', 'MAP2K1', 'MAPK3_T202'], ['MAPK14_T180', 'MAPK14', 'MAPKAPK2_T222', 'MAPKAPK2', 'AKT1_S473', 'AKT1', 'RAF1_S259', 'RAF1', 'MAP2K1_S218', 'MAP2K1', 'MAPK3_T202'], ['MAPK14_T180', 'MAPK14', 'MAPKAPK2_T222', 'MAPKAPK2', 'AKT1_S473', 'AKT1', 'BRAF_S429', 'BRAF', 'MAP2K1_S222', 'MAP2K1', 'MAPK3_T202'], ['MAPK14_T180', 'MAPK14', 'MAPKAPK2_T222', 'MAPKAPK2', 'AKT1_S473', 'AKT1', 'BRAF_S429', 'BRAF', 'MAP2K1_S218', 'MAP2K1', 'MAPK3_T202'], ['MAPK14_T180', 'MAPK14', 'MAPKAPK2_T222', 'MAPKAPK2', 'AKT1_S473', 'AKT1', 'BRAF_S365', 'BRAF', 'MAP2K1_S222', 'MAP2K1', 'MAPK3_T202'], ['MAPK14_T180', 'MAPK14', 'MAPKAPK2_T222', 'MAPKAPK2', 'AKT1_S473', 'AKT1', 'BRAF_S365', 'BRAF', 'MAP2K1_S218', 'MAP2K1', 'MAPK3_T202'], ['MAPK14_T180', 'MAPK14', 'MAPKAPK2_T334', 'MAPKAPK2', 'AKT1_S473', 'AKT1', 'RAF1_S259', 'RAF1', 'MAP2K1_S222', 'MAP2K1', 'MAPK3_T202'], ['MAPK14_T180', 'MAPK14', 'MAPKAPK2_T334', 'MAPKAPK2', 'AKT1_S473', 'AKT1', 'RAF1_S259', 'RAF1', 'MAP2K1_S218', 'MAP2K1', 'MAPK3_T202'], ['MAPK14_T180', 'MAPK14', 'MAPKAPK2_T334', 'MAPKAPK2', 'AKT1_S473', 'AKT1', 'BRAF_S429', 'BRAF', 'MAP2K1_S222', 'MAP2K1', 'MAPK3_T202'], ['MAPK14_T180', 'MAPK14', 'MAPKAPK2_T334', 'MAPKAPK2', 'AKT1_S473', 'AKT1', 'BRAF_S429', 'BRAF', 'MAP2K1_S218', 'MAP2K1', 'MAPK3_T202'], ['MAPK14_T180', 'MAPK14', 'MAPKAPK2_T334', 'MAPKAPK2', 'AKT1_S473', 'AKT1', 'BRAF_S365', 'BRAF', 'MAP2K1_S222', 'MAP2K1', 'MAPK3_T202'], ['MAPK14_T180', 'MAPK14', 'MAPKAPK2_T334', 'MAPKAPK2', 'AKT1_S473', 'AKT1', 'BRAF_S365', 'BRAF', 'MAP2K1_S218', 'MAP2K1', 'MAPK3_T202']]\n", + "looking for paths in the network with length: 0 for node MAPK14_T180 and MAPK3_Y204\n", + "looking for paths in the network with length: 1 for node MAPK14_T180 and MAPK3_Y204\n", + "looking for paths in the network with length: 2 for node MAPK14_T180 and MAPK3_Y204\n", + "looking for paths in the network with length: 3 for node MAPK14_T180 and MAPK3_Y204\n", + "looking for paths in the network with length: 4 for node MAPK14_T180 and MAPK3_Y204\n", + "looking for paths in the network with length: 5 for node MAPK14_T180 and MAPK3_Y204\n", + "looking for paths in the network with length: 6 for node MAPK14_T180 and MAPK3_Y204\n", + "looking for paths in the network with length: 7 for node MAPK14_T180 and MAPK3_Y204\n", + "looking for paths in the network with length: 8 for node MAPK14_T180 and MAPK3_Y204\n", + "looking for paths in the network with length: 9 for node MAPK14_T180 and MAPK3_Y204\n", + "looking for paths in the network with length: 10 for node MAPK14_T180 and MAPK3_Y204\n", + "Found a path!\n", + "[['MAPK14_T180', 'MAPK14', 'MAPKAPK2_S272', 'MAPKAPK2', 'AKT1_S473', 'AKT1', 'RAF1_S259', 'RAF1', 'MAP2K1_S222', 'MAP2K1', 'MAPK3_Y204'], ['MAPK14_T180', 'MAPK14', 'MAPKAPK2_S272', 'MAPKAPK2', 'AKT1_S473', 'AKT1', 'RAF1_S259', 'RAF1', 'MAP2K1_S218', 'MAP2K1', 'MAPK3_Y204'], ['MAPK14_T180', 'MAPK14', 'MAPKAPK2_S272', 'MAPKAPK2', 'AKT1_S473', 'AKT1', 'BRAF_S429', 'BRAF', 'MAP2K1_S222', 'MAP2K1', 'MAPK3_Y204'], ['MAPK14_T180', 'MAPK14', 'MAPKAPK2_S272', 'MAPKAPK2', 'AKT1_S473', 'AKT1', 'BRAF_S429', 'BRAF', 'MAP2K1_S218', 'MAP2K1', 'MAPK3_Y204'], ['MAPK14_T180', 'MAPK14', 'MAPKAPK2_S272', 'MAPKAPK2', 'AKT1_S473', 'AKT1', 'BRAF_S365', 'BRAF', 'MAP2K1_S222', 'MAP2K1', 'MAPK3_Y204'], ['MAPK14_T180', 'MAPK14', 'MAPKAPK2_S272', 'MAPKAPK2', 'AKT1_S473', 'AKT1', 'BRAF_S365', 'BRAF', 'MAP2K1_S218', 'MAP2K1', 'MAPK3_Y204'], ['MAPK14_T180', 'MAPK14', 'MAPKAPK2_T222', 'MAPKAPK2', 'AKT1_S473', 'AKT1', 'RAF1_S259', 'RAF1', 'MAP2K1_S222', 'MAP2K1', 'MAPK3_Y204'], ['MAPK14_T180', 'MAPK14', 'MAPKAPK2_T222', 'MAPKAPK2', 'AKT1_S473', 'AKT1', 'RAF1_S259', 'RAF1', 'MAP2K1_S218', 'MAP2K1', 'MAPK3_Y204'], ['MAPK14_T180', 'MAPK14', 'MAPKAPK2_T222', 'MAPKAPK2', 'AKT1_S473', 'AKT1', 'BRAF_S429', 'BRAF', 'MAP2K1_S222', 'MAP2K1', 'MAPK3_Y204'], ['MAPK14_T180', 'MAPK14', 'MAPKAPK2_T222', 'MAPKAPK2', 'AKT1_S473', 'AKT1', 'BRAF_S429', 'BRAF', 'MAP2K1_S218', 'MAP2K1', 'MAPK3_Y204'], ['MAPK14_T180', 'MAPK14', 'MAPKAPK2_T222', 'MAPKAPK2', 'AKT1_S473', 'AKT1', 'BRAF_S365', 'BRAF', 'MAP2K1_S222', 'MAP2K1', 'MAPK3_Y204'], ['MAPK14_T180', 'MAPK14', 'MAPKAPK2_T222', 'MAPKAPK2', 'AKT1_S473', 'AKT1', 'BRAF_S365', 'BRAF', 'MAP2K1_S218', 'MAP2K1', 'MAPK3_Y204'], ['MAPK14_T180', 'MAPK14', 'MAPKAPK2_T334', 'MAPKAPK2', 'AKT1_S473', 'AKT1', 'RAF1_S259', 'RAF1', 'MAP2K1_S222', 'MAP2K1', 'MAPK3_Y204'], ['MAPK14_T180', 'MAPK14', 'MAPKAPK2_T334', 'MAPKAPK2', 'AKT1_S473', 'AKT1', 'RAF1_S259', 'RAF1', 'MAP2K1_S218', 'MAP2K1', 'MAPK3_Y204'], ['MAPK14_T180', 'MAPK14', 'MAPKAPK2_T334', 'MAPKAPK2', 'AKT1_S473', 'AKT1', 'BRAF_S429', 'BRAF', 'MAP2K1_S222', 'MAP2K1', 'MAPK3_Y204'], ['MAPK14_T180', 'MAPK14', 'MAPKAPK2_T334', 'MAPKAPK2', 'AKT1_S473', 'AKT1', 'BRAF_S429', 'BRAF', 'MAP2K1_S218', 'MAP2K1', 'MAPK3_Y204'], ['MAPK14_T180', 'MAPK14', 'MAPKAPK2_T334', 'MAPKAPK2', 'AKT1_S473', 'AKT1', 'BRAF_S365', 'BRAF', 'MAP2K1_S222', 'MAP2K1', 'MAPK3_Y204'], ['MAPK14_T180', 'MAPK14', 'MAPKAPK2_T334', 'MAPKAPK2', 'AKT1_S473', 'AKT1', 'BRAF_S365', 'BRAF', 'MAP2K1_S218', 'MAP2K1', 'MAPK3_Y204']]\n", + "looking for paths in the network with length: 0 for node MAPK14_T180 and PTPN11_Y542\n", + "looking for paths in the network with length: 1 for node MAPK14_T180 and PTPN11_Y542\n", + "looking for paths in the network with length: 2 for node MAPK14_T180 and PTPN11_Y542\n", + "looking for paths in the network with length: 3 for node MAPK14_T180 and PTPN11_Y542\n", + "looking for paths in the network with length: 4 for node MAPK14_T180 and PTPN11_Y542\n", + "looking for paths in the network with length: 5 for node MAPK14_T180 and PTPN11_Y542\n", + "looking for paths in the network with length: 6 for node MAPK14_T180 and PTPN11_Y542\n", + "looking for paths in the network with length: 7 for node MAPK14_T180 and PTPN11_Y542\n", + "looking for paths in the network with length: 8 for node MAPK14_T180 and PTPN11_Y542\n", + "looking for paths in the network with length: 9 for node MAPK14_T180 and PTPN11_Y542\n", + "looking for paths in the network with length: 10 for node MAPK14_T180 and PTPN11_Y542\n", + "i_search = 4\n", + "Looking for paths with length: 0 for node MAPK14_T180 and PTPN11_Y542\n", + "i_search = 4\n", + "Looking for paths with length: 1 for node MAPK14_T180 and PTPN11_Y542\n", + "i_search = 4\n", + "Looking for paths with length: 2 for node MAPK14_T180 and PTPN11_Y542\n", + "i_search = 4\n", + "Looking for paths with length: 3 for node MAPK14_T180 and PTPN11_Y542\n", + "i_search = 4\n", + "Looking for paths with length: 4 for node MAPK14_T180 and PTPN11_Y542\n", + "looking for paths in the network with length: 0 for node MAPK14_T180 and STAT3_Y705\n", + "looking for paths in the network with length: 1 for node MAPK14_T180 and STAT3_Y705\n", + "looking for paths in the network with length: 2 for node MAPK14_T180 and STAT3_Y705\n", + "looking for paths in the network with length: 3 for node MAPK14_T180 and STAT3_Y705\n", + "looking for paths in the network with length: 4 for node MAPK14_T180 and STAT3_Y705\n", + "looking for paths in the network with length: 5 for node MAPK14_T180 and STAT3_Y705\n", + "looking for paths in the network with length: 6 for node MAPK14_T180 and STAT3_Y705\n", + "Found a path!\n", + "[['MAPK14_T180', 'MAPK14', 'GSK3B_T390', 'GSK3B', 'SRC_S493', 'SRC', 'STAT3_Y705'], ['MAPK14_T180', 'MAPK14', 'GSK3B_T390', 'GSK3B', 'SRC_S51', 'SRC', 'STAT3_Y705'], ['MAPK14_T180', 'MAPK14', 'GSK3B_T390', 'GSK3B', 'SRC_S43', 'SRC', 'STAT3_Y705'], ['MAPK14_T180', 'MAPK14', 'GSK3B_T390', 'GSK3B', 'SRC_Y419', 'SRC', 'STAT3_Y705'], ['MAPK14_T180', 'MAPK14', 'GSK3B_T43', 'GSK3B', 'SRC_S493', 'SRC', 'STAT3_Y705'], ['MAPK14_T180', 'MAPK14', 'GSK3B_T43', 'GSK3B', 'SRC_S51', 'SRC', 'STAT3_Y705'], ['MAPK14_T180', 'MAPK14', 'GSK3B_T43', 'GSK3B', 'SRC_S43', 'SRC', 'STAT3_Y705'], ['MAPK14_T180', 'MAPK14', 'GSK3B_T43', 'GSK3B', 'SRC_Y419', 'SRC', 'STAT3_Y705']]\n", + "looking for paths in the network with length: 0 for node MAPK14_T180 and CHEK2_T68\n", + "looking for paths in the network with length: 1 for node MAPK14_T180 and CHEK2_T68\n", + "looking for paths in the network with length: 2 for node MAPK14_T180 and CHEK2_T68\n", + "looking for paths in the network with length: 3 for node MAPK14_T180 and CHEK2_T68\n", + "looking for paths in the network with length: 4 for node MAPK14_T180 and CHEK2_T68\n", + "looking for paths in the network with length: 5 for node MAPK14_T180 and CHEK2_T68\n", + "looking for paths in the network with length: 6 for node MAPK14_T180 and CHEK2_T68\n", + "looking for paths in the network with length: 7 for node MAPK14_T180 and CHEK2_T68\n", + "looking for paths in the network with length: 8 for node MAPK14_T180 and CHEK2_T68\n", + "looking for paths in the network with length: 9 for node MAPK14_T180 and CHEK2_T68\n", + "looking for paths in the network with length: 10 for node MAPK14_T180 and CHEK2_T68\n", + "i_search = 4\n", + "Looking for paths with length: 0 for node MAPK14_T180 and CHEK2_T68\n", + "i_search = 4\n", + "Looking for paths with length: 1 for node MAPK14_T180 and CHEK2_T68\n", + "i_search = 4\n", + "Looking for paths with length: 2 for node MAPK14_T180 and CHEK2_T68\n", + "i_search = 4\n", + "Looking for paths with length: 3 for node MAPK14_T180 and CHEK2_T68\n", + "i_search = 4\n", + "Looking for paths with length: 4 for node MAPK14_T180 and CHEK2_T68\n", + "looking for paths in the network with length: 0 for node MAPK14_T180 and RELA_S536\n", + "looking for paths in the network with length: 1 for node MAPK14_T180 and RELA_S536\n", + "looking for paths in the network with length: 2 for node MAPK14_T180 and RELA_S536\n", + "looking for paths in the network with length: 3 for node MAPK14_T180 and RELA_S536\n", + "looking for paths in the network with length: 4 for node MAPK14_T180 and RELA_S536\n", + "looking for paths in the network with length: 5 for node MAPK14_T180 and RELA_S536\n", + "looking for paths in the network with length: 6 for node MAPK14_T180 and RELA_S536\n", + "Found a path!\n", + "[['MAPK14_T180', 'MAPK14', 'GSK3B_T390', 'GSK3B', 'TBK1_S172', 'TBK1', 'RELA_S536'], ['MAPK14_T180', 'MAPK14', 'GSK3B_T43', 'GSK3B', 'TBK1_S172', 'TBK1', 'RELA_S536']]\n", + "looking for paths in the network with length: 0 for node MAPK14_T180 and MARCKS_S170\n", + "looking for paths in the network with length: 1 for node MAPK14_T180 and MARCKS_S170\n", + "looking for paths in the network with length: 2 for node MAPK14_T180 and MARCKS_S170\n", + "looking for paths in the network with length: 3 for node MAPK14_T180 and MARCKS_S170\n", + "looking for paths in the network with length: 4 for node MAPK14_T180 and MARCKS_S170\n", + "looking for paths in the network with length: 5 for node MAPK14_T180 and MARCKS_S170\n", + "looking for paths in the network with length: 6 for node MAPK14_T180 and MARCKS_S170\n", + "looking for paths in the network with length: 7 for node MAPK14_T180 and MARCKS_S170\n", + "looking for paths in the network with length: 8 for node MAPK14_T180 and MARCKS_S170\n", + "looking for paths in the network with length: 9 for node MAPK14_T180 and MARCKS_S170\n", + "looking for paths in the network with length: 10 for node MAPK14_T180 and MARCKS_S170\n", + "i_search = 4\n", + "Looking for paths with length: 0 for node MAPK14_T180 and MARCKS_S170\n", + "i_search = 4\n", + "Looking for paths with length: 1 for node MAPK14_T180 and MARCKS_S170\n", + "i_search = 4\n", + "Looking for paths with length: 2 for node MAPK14_T180 and MARCKS_S170\n", + "i_search = 4\n", + "Looking for paths with length: 3 for node MAPK14_T180 and MARCKS_S170\n", + "i_search = 4\n", + "Looking for paths with length: 4 for node MAPK14_T180 and MARCKS_S170\n", + "looking for paths in the network with length: 0 for node MAPK14_T180 and SMAD3\n", + "looking for paths in the network with length: 1 for node MAPK14_T180 and SMAD3\n", + "looking for paths in the network with length: 2 for node MAPK14_T180 and SMAD3\n", + "looking for paths in the network with length: 3 for node MAPK14_T180 and SMAD3\n", + "looking for paths in the network with length: 4 for node MAPK14_T180 and SMAD3\n", + "looking for paths in the network with length: 5 for node MAPK14_T180 and SMAD3\n", + "looking for paths in the network with length: 6 for node MAPK14_T180 and SMAD3\n", + "looking for paths in the network with length: 7 for node MAPK14_T180 and SMAD3\n", + "looking for paths in the network with length: 8 for node MAPK14_T180 and SMAD3\n", + "looking for paths in the network with length: 9 for node MAPK14_T180 and SMAD3\n", + "looking for paths in the network with length: 10 for node MAPK14_T180 and SMAD3\n", + "i_search = 4\n", + "Looking for paths with length: 0 for node MAPK14_T180 and SMAD3\n", + "i_search = 4\n", + "Looking for paths with length: 1 for node MAPK14_T180 and SMAD3\n", + "i_search = 4\n", + "Looking for paths with length: 2 for node MAPK14_T180 and SMAD3\n", + "i_search = 4\n", + "Looking for paths with length: 3 for node MAPK14_T180 and SMAD3\n", + "i_search = 4\n", + "Looking for paths with length: 4 for node MAPK14_T180 and SMAD3\n", + "looking for paths in the network with length: 0 for node MAPK14_T180 and TP53\n", + "looking for paths in the network with length: 1 for node MAPK14_T180 and TP53\n", + "looking for paths in the network with length: 2 for node MAPK14_T180 and TP53\n", + "looking for paths in the network with length: 3 for node MAPK14_T180 and TP53\n", + "looking for paths in the network with length: 4 for node MAPK14_T180 and TP53\n", + "looking for paths in the network with length: 5 for node MAPK14_T180 and TP53\n", + "looking for paths in the network with length: 6 for node MAPK14_T180 and TP53\n", + "looking for paths in the network with length: 7 for node MAPK14_T180 and TP53\n", + "looking for paths in the network with length: 8 for node MAPK14_T180 and TP53\n", + "looking for paths in the network with length: 9 for node MAPK14_T180 and TP53\n", + "looking for paths in the network with length: 10 for node MAPK14_T180 and TP53\n", + "i_search = 4\n", + "Looking for paths with length: 0 for node MAPK14_T180 and TP53\n", + "i_search = 4\n", + "Looking for paths with length: 1 for node MAPK14_T180 and TP53\n", + "i_search = 4\n", + "Looking for paths with length: 2 for node MAPK14_T180 and TP53\n", + "i_search = 4\n", + "Looking for paths with length: 3 for node MAPK14_T180 and TP53\n", + "i_search = 4\n", + "Looking for paths with length: 4 for node MAPK14_T180 and TP53\n", + "looking for paths in the network with length: 0 for node MAPK14_T180 and AKT1S1\n", + "looking for paths in the network with length: 1 for node MAPK14_T180 and AKT1S1\n", + "looking for paths in the network with length: 2 for node MAPK14_T180 and AKT1S1\n", + "looking for paths in the network with length: 3 for node MAPK14_T180 and AKT1S1\n", + "looking for paths in the network with length: 4 for node MAPK14_T180 and AKT1S1\n", + "looking for paths in the network with length: 5 for node MAPK14_T180 and AKT1S1\n", + "looking for paths in the network with length: 6 for node MAPK14_T180 and AKT1S1\n", + "looking for paths in the network with length: 7 for node MAPK14_T180 and AKT1S1\n", + "looking for paths in the network with length: 8 for node MAPK14_T180 and AKT1S1\n", + "looking for paths in the network with length: 9 for node MAPK14_T180 and AKT1S1\n", + "looking for paths in the network with length: 10 for node MAPK14_T180 and AKT1S1\n", + "i_search = 4\n", + "Looking for paths with length: 0 for node MAPK14_T180 and AKT1S1\n", + "i_search = 4\n", + "Looking for paths with length: 1 for node MAPK14_T180 and AKT1S1\n", + "i_search = 4\n", + "Looking for paths with length: 2 for node MAPK14_T180 and AKT1S1\n", + "i_search = 4\n", + "Looking for paths with length: 3 for node MAPK14_T180 and AKT1S1\n", + "i_search = 4\n", + "Looking for paths with length: 4 for node MAPK14_T180 and AKT1S1\n", + "looking for paths in the network with length: 0 for node MAPK14_T180 and GSK3B\n", + "looking for paths in the network with length: 1 for node MAPK14_T180 and GSK3B\n", + "looking for paths in the network with length: 2 for node MAPK14_T180 and GSK3B\n", + "looking for paths in the network with length: 3 for node MAPK14_T180 and GSK3B\n", + "looking for paths in the network with length: 4 for node MAPK14_T180 and GSK3B\n", + "looking for paths in the network with length: 5 for node MAPK14_T180 and GSK3B\n", + "looking for paths in the network with length: 6 for node MAPK14_T180 and GSK3B\n", + "looking for paths in the network with length: 7 for node MAPK14_T180 and GSK3B\n", + "looking for paths in the network with length: 8 for node MAPK14_T180 and GSK3B\n", + "looking for paths in the network with length: 9 for node MAPK14_T180 and GSK3B\n", + "looking for paths in the network with length: 10 for node MAPK14_T180 and GSK3B\n", + "i_search = 4\n", + "Looking for paths with length: 0 for node MAPK14_T180 and GSK3B\n", + "i_search = 4\n", + "Looking for paths with length: 1 for node MAPK14_T180 and GSK3B\n", + "i_search = 4\n", + "Looking for paths with length: 2 for node MAPK14_T180 and GSK3B\n", + "i_search = 4\n", + "Looking for paths with length: 3 for node MAPK14_T180 and GSK3B\n", + "i_search = 4\n", + "Looking for paths with length: 4 for node MAPK14_T180 and GSK3B\n", + "looking for paths in the network with length: 0 for node MAPK14_T180 and AKT1\n", + "looking for paths in the network with length: 1 for node MAPK14_T180 and AKT1\n", + "looking for paths in the network with length: 2 for node MAPK14_T180 and AKT1\n", + "looking for paths in the network with length: 3 for node MAPK14_T180 and AKT1\n", + "looking for paths in the network with length: 4 for node MAPK14_T180 and AKT1\n", + "looking for paths in the network with length: 5 for node MAPK14_T180 and AKT1\n", + "looking for paths in the network with length: 6 for node MAPK14_T180 and AKT1\n", + "looking for paths in the network with length: 7 for node MAPK14_T180 and AKT1\n", + "looking for paths in the network with length: 8 for node MAPK14_T180 and AKT1\n", + "looking for paths in the network with length: 9 for node MAPK14_T180 and AKT1\n", + "looking for paths in the network with length: 10 for node MAPK14_T180 and AKT1\n", + "i_search = 4\n", + "Looking for paths with length: 0 for node MAPK14_T180 and AKT1\n", + "i_search = 4\n", + "Looking for paths with length: 1 for node MAPK14_T180 and AKT1\n", + "i_search = 4\n", + "Looking for paths with length: 2 for node MAPK14_T180 and AKT1\n", + "i_search = 4\n", + "Looking for paths with length: 3 for node MAPK14_T180 and AKT1\n", + "i_search = 4\n", + "Looking for paths with length: 4 for node MAPK14_T180 and AKT1\n", + "looking for paths in the network with length: 0 for node MAPK14_T180 and HSPB1\n", + "looking for paths in the network with length: 1 for node MAPK14_T180 and HSPB1\n", + "looking for paths in the network with length: 2 for node MAPK14_T180 and HSPB1\n", + "looking for paths in the network with length: 3 for node MAPK14_T180 and HSPB1\n", + "looking for paths in the network with length: 4 for node MAPK14_T180 and HSPB1\n", + "looking for paths in the network with length: 5 for node MAPK14_T180 and HSPB1\n", + "looking for paths in the network with length: 6 for node MAPK14_T180 and HSPB1\n", + "looking for paths in the network with length: 7 for node MAPK14_T180 and HSPB1\n", + "looking for paths in the network with length: 8 for node MAPK14_T180 and HSPB1\n", + "looking for paths in the network with length: 9 for node MAPK14_T180 and HSPB1\n", + "looking for paths in the network with length: 10 for node MAPK14_T180 and HSPB1\n", + "i_search = 4\n", + "Looking for paths with length: 0 for node MAPK14_T180 and HSPB1\n", + "i_search = 4\n", + "Looking for paths with length: 1 for node MAPK14_T180 and HSPB1\n", + "i_search = 4\n", + "Looking for paths with length: 2 for node MAPK14_T180 and HSPB1\n", + "i_search = 4\n", + "Looking for paths with length: 3 for node MAPK14_T180 and HSPB1\n", + "i_search = 4\n", + "Looking for paths with length: 4 for node MAPK14_T180 and HSPB1\n", + "looking for paths in the network with length: 0 for node MAPK14_T180 and MAPK14\n", + "looking for paths in the network with length: 1 for node MAPK14_T180 and MAPK14\n", + "looking for paths in the network with length: 2 for node MAPK14_T180 and MAPK14\n", + "looking for paths in the network with length: 3 for node MAPK14_T180 and MAPK14\n", + "looking for paths in the network with length: 4 for node MAPK14_T180 and MAPK14\n", + "looking for paths in the network with length: 5 for node MAPK14_T180 and MAPK14\n", + "looking for paths in the network with length: 6 for node MAPK14_T180 and MAPK14\n", + "looking for paths in the network with length: 7 for node MAPK14_T180 and MAPK14\n", + "looking for paths in the network with length: 8 for node MAPK14_T180 and MAPK14\n", + "looking for paths in the network with length: 9 for node MAPK14_T180 and MAPK14\n", + "looking for paths in the network with length: 10 for node MAPK14_T180 and MAPK14\n", + "i_search = 4\n", + "Looking for paths with length: 0 for node MAPK14_T180 and MAPK14\n", + "i_search = 4\n", + "Looking for paths with length: 1 for node MAPK14_T180 and MAPK14\n", + "i_search = 4\n", + "Looking for paths with length: 2 for node MAPK14_T180 and MAPK14\n", + "i_search = 4\n", + "Looking for paths with length: 3 for node MAPK14_T180 and MAPK14\n", + "i_search = 4\n", + "Looking for paths with length: 4 for node MAPK14_T180 and MAPK14\n", + "looking for paths in the network with length: 0 for node MAPK14_T180 and MAP2K1\n", + "looking for paths in the network with length: 1 for node MAPK14_T180 and MAP2K1\n", + "looking for paths in the network with length: 2 for node MAPK14_T180 and MAP2K1\n", + "looking for paths in the network with length: 3 for node MAPK14_T180 and MAP2K1\n", + "looking for paths in the network with length: 4 for node MAPK14_T180 and MAP2K1\n", + "looking for paths in the network with length: 5 for node MAPK14_T180 and MAP2K1\n", + "looking for paths in the network with length: 6 for node MAPK14_T180 and MAP2K1\n", + "looking for paths in the network with length: 7 for node MAPK14_T180 and MAP2K1\n", + "looking for paths in the network with length: 8 for node MAPK14_T180 and MAP2K1\n", + "looking for paths in the network with length: 9 for node MAPK14_T180 and MAP2K1\n", + "looking for paths in the network with length: 10 for node MAPK14_T180 and MAP2K1\n", + "i_search = 4\n", + "Looking for paths with length: 0 for node MAPK14_T180 and MAP2K1\n", + "i_search = 4\n", + "Looking for paths with length: 1 for node MAPK14_T180 and MAP2K1\n", + "i_search = 4\n", + "Looking for paths with length: 2 for node MAPK14_T180 and MAP2K1\n", + "i_search = 4\n", + "Looking for paths with length: 3 for node MAPK14_T180 and MAP2K1\n", + "i_search = 4\n", + "Looking for paths with length: 4 for node MAPK14_T180 and MAP2K1\n", + "looking for paths in the network with length: 0 for node MAPK14_T180 and RPS6KA1\n", + "looking for paths in the network with length: 1 for node MAPK14_T180 and RPS6KA1\n", + "looking for paths in the network with length: 2 for node MAPK14_T180 and RPS6KA1\n", + "looking for paths in the network with length: 3 for node MAPK14_T180 and RPS6KA1\n", + "looking for paths in the network with length: 4 for node MAPK14_T180 and RPS6KA1\n", + "looking for paths in the network with length: 5 for node MAPK14_T180 and RPS6KA1\n", + "looking for paths in the network with length: 6 for node MAPK14_T180 and RPS6KA1\n", + "looking for paths in the network with length: 7 for node MAPK14_T180 and RPS6KA1\n", + "looking for paths in the network with length: 8 for node MAPK14_T180 and RPS6KA1\n", + "looking for paths in the network with length: 9 for node MAPK14_T180 and RPS6KA1\n", + "looking for paths in the network with length: 10 for node MAPK14_T180 and RPS6KA1\n", + "i_search = 4\n", + "Looking for paths with length: 0 for node MAPK14_T180 and RPS6KA1\n", + "i_search = 4\n", + "Looking for paths with length: 1 for node MAPK14_T180 and RPS6KA1\n", + "i_search = 4\n", + "Looking for paths with length: 2 for node MAPK14_T180 and RPS6KA1\n", + "i_search = 4\n", + "Looking for paths with length: 3 for node MAPK14_T180 and RPS6KA1\n", + "i_search = 4\n", + "Looking for paths with length: 4 for node MAPK14_T180 and RPS6KA1\n", + "looking for paths in the network with length: 0 for node MAPK14_T180 and CREB1\n", + "looking for paths in the network with length: 1 for node MAPK14_T180 and CREB1\n", + "looking for paths in the network with length: 2 for node MAPK14_T180 and CREB1\n", + "looking for paths in the network with length: 3 for node MAPK14_T180 and CREB1\n", + "looking for paths in the network with length: 4 for node MAPK14_T180 and CREB1\n", + "looking for paths in the network with length: 5 for node MAPK14_T180 and CREB1\n", + "looking for paths in the network with length: 6 for node MAPK14_T180 and CREB1\n", + "looking for paths in the network with length: 7 for node MAPK14_T180 and CREB1\n", + "looking for paths in the network with length: 8 for node MAPK14_T180 and CREB1\n", + "looking for paths in the network with length: 9 for node MAPK14_T180 and CREB1\n", + "looking for paths in the network with length: 10 for node MAPK14_T180 and CREB1\n", + "i_search = 4\n", + "Looking for paths with length: 0 for node MAPK14_T180 and CREB1\n", + "i_search = 4\n", + "Looking for paths with length: 1 for node MAPK14_T180 and CREB1\n", + "i_search = 4\n", + "Looking for paths with length: 2 for node MAPK14_T180 and CREB1\n", + "i_search = 4\n", + "Looking for paths with length: 3 for node MAPK14_T180 and CREB1\n", + "i_search = 4\n", + "Looking for paths with length: 4 for node MAPK14_T180 and CREB1\n", + "looking for paths in the network with length: 0 for node MAPK14_T180 and NFKBIA\n", + "looking for paths in the network with length: 1 for node MAPK14_T180 and NFKBIA\n", + "looking for paths in the network with length: 2 for node MAPK14_T180 and NFKBIA\n", + "looking for paths in the network with length: 3 for node MAPK14_T180 and NFKBIA\n", + "looking for paths in the network with length: 4 for node MAPK14_T180 and NFKBIA\n", + "looking for paths in the network with length: 5 for node MAPK14_T180 and NFKBIA\n", + "looking for paths in the network with length: 6 for node MAPK14_T180 and NFKBIA\n", + "looking for paths in the network with length: 7 for node MAPK14_T180 and NFKBIA\n", + "looking for paths in the network with length: 8 for node MAPK14_T180 and NFKBIA\n", + "looking for paths in the network with length: 9 for node MAPK14_T180 and NFKBIA\n", + "looking for paths in the network with length: 10 for node MAPK14_T180 and NFKBIA\n", + "i_search = 4\n", + "Looking for paths with length: 0 for node MAPK14_T180 and NFKBIA\n", + "i_search = 4\n", + "Looking for paths with length: 1 for node MAPK14_T180 and NFKBIA\n", + "i_search = 4\n", + "Looking for paths with length: 2 for node MAPK14_T180 and NFKBIA\n", + "i_search = 4\n", + "Looking for paths with length: 3 for node MAPK14_T180 and NFKBIA\n", + "i_search = 4\n", + "Looking for paths with length: 4 for node MAPK14_T180 and NFKBIA\n", + "looking for paths in the network with length: 0 for node MAPK14_T180 and MTOR\n", + "looking for paths in the network with length: 1 for node MAPK14_T180 and MTOR\n", + "looking for paths in the network with length: 2 for node MAPK14_T180 and MTOR\n", + "looking for paths in the network with length: 3 for node MAPK14_T180 and MTOR\n", + "looking for paths in the network with length: 4 for node MAPK14_T180 and MTOR\n", + "looking for paths in the network with length: 5 for node MAPK14_T180 and MTOR\n", + "looking for paths in the network with length: 6 for node MAPK14_T180 and MTOR\n", + "looking for paths in the network with length: 7 for node MAPK14_T180 and MTOR\n", + "looking for paths in the network with length: 8 for node MAPK14_T180 and MTOR\n", + "looking for paths in the network with length: 9 for node MAPK14_T180 and MTOR\n", + "looking for paths in the network with length: 10 for node MAPK14_T180 and MTOR\n", + "i_search = 4\n", + "Looking for paths with length: 0 for node MAPK14_T180 and MTOR\n", + "i_search = 4\n", + "Looking for paths with length: 1 for node MAPK14_T180 and MTOR\n", + "i_search = 4\n", + "Looking for paths with length: 2 for node MAPK14_T180 and MTOR\n", + "i_search = 4\n", + "Looking for paths with length: 3 for node MAPK14_T180 and MTOR\n", + "i_search = 4\n", + "Looking for paths with length: 4 for node MAPK14_T180 and MTOR\n", + "looking for paths in the network with length: 0 for node MAPK14_T180 and JUN\n", + "looking for paths in the network with length: 1 for node MAPK14_T180 and JUN\n", + "looking for paths in the network with length: 2 for node MAPK14_T180 and JUN\n", + "looking for paths in the network with length: 3 for node MAPK14_T180 and JUN\n", + "looking for paths in the network with length: 4 for node MAPK14_T180 and JUN\n", + "looking for paths in the network with length: 5 for node MAPK14_T180 and JUN\n", + "looking for paths in the network with length: 6 for node MAPK14_T180 and JUN\n", + "looking for paths in the network with length: 7 for node MAPK14_T180 and JUN\n", + "looking for paths in the network with length: 8 for node MAPK14_T180 and JUN\n", + "looking for paths in the network with length: 9 for node MAPK14_T180 and JUN\n", + "looking for paths in the network with length: 10 for node MAPK14_T180 and JUN\n", + "i_search = 4\n", + "Looking for paths with length: 0 for node MAPK14_T180 and JUN\n", + "i_search = 4\n", + "Looking for paths with length: 1 for node MAPK14_T180 and JUN\n", + "i_search = 4\n", + "Looking for paths with length: 2 for node MAPK14_T180 and JUN\n", + "i_search = 4\n", + "Looking for paths with length: 3 for node MAPK14_T180 and JUN\n", + "i_search = 4\n", + "Looking for paths with length: 4 for node MAPK14_T180 and JUN\n", + "looking for paths in the network with length: 0 for node MAPK14_T180 and EGFR\n", + "looking for paths in the network with length: 1 for node MAPK14_T180 and EGFR\n", + "looking for paths in the network with length: 2 for node MAPK14_T180 and EGFR\n", + "looking for paths in the network with length: 3 for node MAPK14_T180 and EGFR\n", + "looking for paths in the network with length: 4 for node MAPK14_T180 and EGFR\n", + "looking for paths in the network with length: 5 for node MAPK14_T180 and EGFR\n", + "looking for paths in the network with length: 6 for node MAPK14_T180 and EGFR\n", + "looking for paths in the network with length: 7 for node MAPK14_T180 and EGFR\n", + "looking for paths in the network with length: 8 for node MAPK14_T180 and EGFR\n", + "looking for paths in the network with length: 9 for node MAPK14_T180 and EGFR\n", + "looking for paths in the network with length: 10 for node MAPK14_T180 and EGFR\n", + "i_search = 4\n", + "Looking for paths with length: 0 for node MAPK14_T180 and EGFR\n", + "i_search = 4\n", + "Looking for paths with length: 1 for node MAPK14_T180 and EGFR\n", + "i_search = 4\n", + "Looking for paths with length: 2 for node MAPK14_T180 and EGFR\n", + "i_search = 4\n", + "Looking for paths with length: 3 for node MAPK14_T180 and EGFR\n", + "i_search = 4\n", + "Looking for paths with length: 4 for node MAPK14_T180 and EGFR\n", + "looking for paths in the network with length: 0 for node MAPK14_T180 and MAPK3\n", + "looking for paths in the network with length: 1 for node MAPK14_T180 and MAPK3\n", + "looking for paths in the network with length: 2 for node MAPK14_T180 and MAPK3\n", + "looking for paths in the network with length: 3 for node MAPK14_T180 and MAPK3\n", + "looking for paths in the network with length: 4 for node MAPK14_T180 and MAPK3\n", + "looking for paths in the network with length: 5 for node MAPK14_T180 and MAPK3\n", + "looking for paths in the network with length: 6 for node MAPK14_T180 and MAPK3\n", + "looking for paths in the network with length: 7 for node MAPK14_T180 and MAPK3\n", + "looking for paths in the network with length: 8 for node MAPK14_T180 and MAPK3\n", + "looking for paths in the network with length: 9 for node MAPK14_T180 and MAPK3\n", + "looking for paths in the network with length: 10 for node MAPK14_T180 and MAPK3\n", + "i_search = 4\n", + "Looking for paths with length: 0 for node MAPK14_T180 and MAPK3\n", + "i_search = 4\n", + "Looking for paths with length: 1 for node MAPK14_T180 and MAPK3\n", + "i_search = 4\n", + "Looking for paths with length: 2 for node MAPK14_T180 and MAPK3\n", + "i_search = 4\n", + "Looking for paths with length: 3 for node MAPK14_T180 and MAPK3\n", + "i_search = 4\n", + "Looking for paths with length: 4 for node MAPK14_T180 and MAPK3\n", + "looking for paths in the network with length: 0 for node MAPK14_T180 and PTPN11\n", + "looking for paths in the network with length: 1 for node MAPK14_T180 and PTPN11\n", + "looking for paths in the network with length: 2 for node MAPK14_T180 and PTPN11\n", + "looking for paths in the network with length: 3 for node MAPK14_T180 and PTPN11\n", + "looking for paths in the network with length: 4 for node MAPK14_T180 and PTPN11\n", + "looking for paths in the network with length: 5 for node MAPK14_T180 and PTPN11\n", + "looking for paths in the network with length: 6 for node MAPK14_T180 and PTPN11\n", + "looking for paths in the network with length: 7 for node MAPK14_T180 and PTPN11\n", + "looking for paths in the network with length: 8 for node MAPK14_T180 and PTPN11\n", + "looking for paths in the network with length: 9 for node MAPK14_T180 and PTPN11\n", + "looking for paths in the network with length: 10 for node MAPK14_T180 and PTPN11\n", + "i_search = 4\n", + "Looking for paths with length: 0 for node MAPK14_T180 and PTPN11\n", + "i_search = 4\n", + "Looking for paths with length: 1 for node MAPK14_T180 and PTPN11\n", + "i_search = 4\n", + "Looking for paths with length: 2 for node MAPK14_T180 and PTPN11\n", + "i_search = 4\n", + "Looking for paths with length: 3 for node MAPK14_T180 and PTPN11\n", + "i_search = 4\n", + "Looking for paths with length: 4 for node MAPK14_T180 and PTPN11\n", + "looking for paths in the network with length: 0 for node MAPK14_T180 and STAT3\n", + "looking for paths in the network with length: 1 for node MAPK14_T180 and STAT3\n", + "looking for paths in the network with length: 2 for node MAPK14_T180 and STAT3\n", + "looking for paths in the network with length: 3 for node MAPK14_T180 and STAT3\n", + "looking for paths in the network with length: 4 for node MAPK14_T180 and STAT3\n", + "looking for paths in the network with length: 5 for node MAPK14_T180 and STAT3\n", + "looking for paths in the network with length: 6 for node MAPK14_T180 and STAT3\n", + "looking for paths in the network with length: 7 for node MAPK14_T180 and STAT3\n", + "looking for paths in the network with length: 8 for node MAPK14_T180 and STAT3\n", + "looking for paths in the network with length: 9 for node MAPK14_T180 and STAT3\n", + "looking for paths in the network with length: 10 for node MAPK14_T180 and STAT3\n", + "i_search = 4\n", + "Looking for paths with length: 0 for node MAPK14_T180 and STAT3\n", + "i_search = 4\n", + "Looking for paths with length: 1 for node MAPK14_T180 and STAT3\n", + "i_search = 4\n", + "Looking for paths with length: 2 for node MAPK14_T180 and STAT3\n", + "i_search = 4\n", + "Looking for paths with length: 3 for node MAPK14_T180 and STAT3\n", + "i_search = 4\n", + "Looking for paths with length: 4 for node MAPK14_T180 and STAT3\n", + "looking for paths in the network with length: 0 for node MAPK14_T180 and CHEK2\n", + "looking for paths in the network with length: 1 for node MAPK14_T180 and CHEK2\n", + "looking for paths in the network with length: 2 for node MAPK14_T180 and CHEK2\n", + "looking for paths in the network with length: 3 for node MAPK14_T180 and CHEK2\n", + "looking for paths in the network with length: 4 for node MAPK14_T180 and CHEK2\n", + "looking for paths in the network with length: 5 for node MAPK14_T180 and CHEK2\n", + "looking for paths in the network with length: 6 for node MAPK14_T180 and CHEK2\n", + "looking for paths in the network with length: 7 for node MAPK14_T180 and CHEK2\n", + "looking for paths in the network with length: 8 for node MAPK14_T180 and CHEK2\n", + "looking for paths in the network with length: 9 for node MAPK14_T180 and CHEK2\n", + "looking for paths in the network with length: 10 for node MAPK14_T180 and CHEK2\n", + "i_search = 4\n", + "Looking for paths with length: 0 for node MAPK14_T180 and CHEK2\n", + "i_search = 4\n", + "Looking for paths with length: 1 for node MAPK14_T180 and CHEK2\n", + "i_search = 4\n", + "Looking for paths with length: 2 for node MAPK14_T180 and CHEK2\n", + "i_search = 4\n", + "Looking for paths with length: 3 for node MAPK14_T180 and CHEK2\n", + "i_search = 4\n", + "Looking for paths with length: 4 for node MAPK14_T180 and CHEK2\n", + "looking for paths in the network with length: 0 for node MAPK14_T180 and RELA\n", + "looking for paths in the network with length: 1 for node MAPK14_T180 and RELA\n", + "looking for paths in the network with length: 2 for node MAPK14_T180 and RELA\n", + "looking for paths in the network with length: 3 for node MAPK14_T180 and RELA\n", + "looking for paths in the network with length: 4 for node MAPK14_T180 and RELA\n", + "looking for paths in the network with length: 5 for node MAPK14_T180 and RELA\n", + "looking for paths in the network with length: 6 for node MAPK14_T180 and RELA\n", + "looking for paths in the network with length: 7 for node MAPK14_T180 and RELA\n", + "looking for paths in the network with length: 8 for node MAPK14_T180 and RELA\n", + "looking for paths in the network with length: 9 for node MAPK14_T180 and RELA\n", + "looking for paths in the network with length: 10 for node MAPK14_T180 and RELA\n", + "i_search = 4\n", + "Looking for paths with length: 0 for node MAPK14_T180 and RELA\n", + "i_search = 4\n", + "Looking for paths with length: 1 for node MAPK14_T180 and RELA\n", + "i_search = 4\n", + "Looking for paths with length: 2 for node MAPK14_T180 and RELA\n", + "i_search = 4\n", + "Looking for paths with length: 3 for node MAPK14_T180 and RELA\n", + "i_search = 4\n", + "Looking for paths with length: 4 for node MAPK14_T180 and RELA\n", + "looking for paths in the network with length: 0 for node MAPK14_T180 and MARCKS\n", + "looking for paths in the network with length: 1 for node MAPK14_T180 and MARCKS\n", + "looking for paths in the network with length: 2 for node MAPK14_T180 and MARCKS\n", + "looking for paths in the network with length: 3 for node MAPK14_T180 and MARCKS\n", + "looking for paths in the network with length: 4 for node MAPK14_T180 and MARCKS\n", + "looking for paths in the network with length: 5 for node MAPK14_T180 and MARCKS\n", + "looking for paths in the network with length: 6 for node MAPK14_T180 and MARCKS\n", + "looking for paths in the network with length: 7 for node MAPK14_T180 and MARCKS\n", + "looking for paths in the network with length: 8 for node MAPK14_T180 and MARCKS\n", + "looking for paths in the network with length: 9 for node MAPK14_T180 and MARCKS\n", + "looking for paths in the network with length: 10 for node MAPK14_T180 and MARCKS\n", + "i_search = 4\n", + "Looking for paths with length: 0 for node MAPK14_T180 and MARCKS\n", + "i_search = 4\n", + "Looking for paths with length: 1 for node MAPK14_T180 and MARCKS\n", + "i_search = 4\n", + "Looking for paths with length: 2 for node MAPK14_T180 and MARCKS\n", + "i_search = 4\n", + "Looking for paths with length: 3 for node MAPK14_T180 and MARCKS\n", + "i_search = 4\n", + "Looking for paths with length: 4 for node MAPK14_T180 and MARCKS\n", + "looking for paths in the network with length: 0 for node MAPK14_Y182 and MAP2K1_S218\n", + "looking for paths in the network with length: 1 for node MAPK14_Y182 and MAP2K1_S218\n", + "looking for paths in the network with length: 2 for node MAPK14_Y182 and MAP2K1_S218\n", + "looking for paths in the network with length: 3 for node MAPK14_Y182 and MAP2K1_S218\n", + "looking for paths in the network with length: 4 for node MAPK14_Y182 and MAP2K1_S218\n", + "looking for paths in the network with length: 5 for node MAPK14_Y182 and MAP2K1_S218\n", + "looking for paths in the network with length: 6 for node MAPK14_Y182 and MAP2K1_S218\n", + "looking for paths in the network with length: 7 for node MAPK14_Y182 and MAP2K1_S218\n", + "looking for paths in the network with length: 8 for node MAPK14_Y182 and MAP2K1_S218\n", + "Found a path!\n", + "[['MAPK14_Y182', 'MAPK14', 'MAPKAPK2_S272', 'MAPKAPK2', 'AKT1_S473', 'AKT1', 'RAF1_S259', 'RAF1', 'MAP2K1_S218'], ['MAPK14_Y182', 'MAPK14', 'MAPKAPK2_S272', 'MAPKAPK2', 'AKT1_S473', 'AKT1', 'BRAF_S429', 'BRAF', 'MAP2K1_S218'], ['MAPK14_Y182', 'MAPK14', 'MAPKAPK2_S272', 'MAPKAPK2', 'AKT1_S473', 'AKT1', 'BRAF_S365', 'BRAF', 'MAP2K1_S218'], ['MAPK14_Y182', 'MAPK14', 'MAPKAPK2_T222', 'MAPKAPK2', 'AKT1_S473', 'AKT1', 'RAF1_S259', 'RAF1', 'MAP2K1_S218'], ['MAPK14_Y182', 'MAPK14', 'MAPKAPK2_T222', 'MAPKAPK2', 'AKT1_S473', 'AKT1', 'BRAF_S429', 'BRAF', 'MAP2K1_S218'], ['MAPK14_Y182', 'MAPK14', 'MAPKAPK2_T222', 'MAPKAPK2', 'AKT1_S473', 'AKT1', 'BRAF_S365', 'BRAF', 'MAP2K1_S218'], ['MAPK14_Y182', 'MAPK14', 'MAPKAPK2_T334', 'MAPKAPK2', 'AKT1_S473', 'AKT1', 'RAF1_S259', 'RAF1', 'MAP2K1_S218'], ['MAPK14_Y182', 'MAPK14', 'MAPKAPK2_T334', 'MAPKAPK2', 'AKT1_S473', 'AKT1', 'BRAF_S429', 'BRAF', 'MAP2K1_S218'], ['MAPK14_Y182', 'MAPK14', 'MAPKAPK2_T334', 'MAPKAPK2', 'AKT1_S473', 'AKT1', 'BRAF_S365', 'BRAF', 'MAP2K1_S218']]\n", + "looking for paths in the network with length: 0 for node MAPK14_Y182 and MAP2K1_S222\n", + "looking for paths in the network with length: 1 for node MAPK14_Y182 and MAP2K1_S222\n", + "looking for paths in the network with length: 2 for node MAPK14_Y182 and MAP2K1_S222\n", + "looking for paths in the network with length: 3 for node MAPK14_Y182 and MAP2K1_S222\n", + "looking for paths in the network with length: 4 for node MAPK14_Y182 and MAP2K1_S222\n", + "looking for paths in the network with length: 5 for node MAPK14_Y182 and MAP2K1_S222\n", + "looking for paths in the network with length: 6 for node MAPK14_Y182 and MAP2K1_S222\n", + "looking for paths in the network with length: 7 for node MAPK14_Y182 and MAP2K1_S222\n", + "looking for paths in the network with length: 8 for node MAPK14_Y182 and MAP2K1_S222\n", + "Found a path!\n", + "[['MAPK14_Y182', 'MAPK14', 'MAPKAPK2_S272', 'MAPKAPK2', 'AKT1_S473', 'AKT1', 'RAF1_S259', 'RAF1', 'MAP2K1_S222'], ['MAPK14_Y182', 'MAPK14', 'MAPKAPK2_S272', 'MAPKAPK2', 'AKT1_S473', 'AKT1', 'BRAF_S429', 'BRAF', 'MAP2K1_S222'], ['MAPK14_Y182', 'MAPK14', 'MAPKAPK2_S272', 'MAPKAPK2', 'AKT1_S473', 'AKT1', 'BRAF_S365', 'BRAF', 'MAP2K1_S222'], ['MAPK14_Y182', 'MAPK14', 'MAPKAPK2_T222', 'MAPKAPK2', 'AKT1_S473', 'AKT1', 'RAF1_S259', 'RAF1', 'MAP2K1_S222'], ['MAPK14_Y182', 'MAPK14', 'MAPKAPK2_T222', 'MAPKAPK2', 'AKT1_S473', 'AKT1', 'BRAF_S429', 'BRAF', 'MAP2K1_S222'], ['MAPK14_Y182', 'MAPK14', 'MAPKAPK2_T222', 'MAPKAPK2', 'AKT1_S473', 'AKT1', 'BRAF_S365', 'BRAF', 'MAP2K1_S222'], ['MAPK14_Y182', 'MAPK14', 'MAPKAPK2_T334', 'MAPKAPK2', 'AKT1_S473', 'AKT1', 'RAF1_S259', 'RAF1', 'MAP2K1_S222'], ['MAPK14_Y182', 'MAPK14', 'MAPKAPK2_T334', 'MAPKAPK2', 'AKT1_S473', 'AKT1', 'BRAF_S429', 'BRAF', 'MAP2K1_S222'], ['MAPK14_Y182', 'MAPK14', 'MAPKAPK2_T334', 'MAPKAPK2', 'AKT1_S473', 'AKT1', 'BRAF_S365', 'BRAF', 'MAP2K1_S222']]\n", + "looking for paths in the network with length: 0 for node MAPK14_Y182 and RPS6KA1_S380\n", + "looking for paths in the network with length: 1 for node MAPK14_Y182 and RPS6KA1_S380\n", + "looking for paths in the network with length: 2 for node MAPK14_Y182 and RPS6KA1_S380\n", + "looking for paths in the network with length: 3 for node MAPK14_Y182 and RPS6KA1_S380\n", + "looking for paths in the network with length: 4 for node MAPK14_Y182 and RPS6KA1_S380\n", + "Found a path!\n", + "[['MAPK14_Y182', 'MAPK14', 'MAPKAPK2_S272', 'MAPKAPK2', 'RPS6KA1_S380'], ['MAPK14_Y182', 'MAPK14', 'MAPKAPK2_T222', 'MAPKAPK2', 'RPS6KA1_S380'], ['MAPK14_Y182', 'MAPK14', 'MAPKAPK2_T334', 'MAPKAPK2', 'RPS6KA1_S380']]\n", + "looking for paths in the network with length: 0 for node MAPK14_Y182 and CREB1_S133\n", + "looking for paths in the network with length: 1 for node MAPK14_Y182 and CREB1_S133\n", + "looking for paths in the network with length: 2 for node MAPK14_Y182 and CREB1_S133\n", + "looking for paths in the network with length: 3 for node MAPK14_Y182 and CREB1_S133\n", + "looking for paths in the network with length: 4 for node MAPK14_Y182 and CREB1_S133\n", + "looking for paths in the network with length: 5 for node MAPK14_Y182 and CREB1_S133\n", + "looking for paths in the network with length: 6 for node MAPK14_Y182 and CREB1_S133\n", + "looking for paths in the network with length: 7 for node MAPK14_Y182 and CREB1_S133\n", + "looking for paths in the network with length: 8 for node MAPK14_Y182 and CREB1_S133\n", + "looking for paths in the network with length: 9 for node MAPK14_Y182 and CREB1_S133\n", + "looking for paths in the network with length: 10 for node MAPK14_Y182 and CREB1_S133\n", + "i_search = 4\n", + "Looking for paths with length: 0 for node MAPK14_Y182 and CREB1_S133\n", + "i_search = 4\n", + "Looking for paths with length: 1 for node MAPK14_Y182 and CREB1_S133\n", + "i_search = 4\n", + "Looking for paths with length: 2 for node MAPK14_Y182 and CREB1_S133\n", + "i_search = 4\n", + "Looking for paths with length: 3 for node MAPK14_Y182 and CREB1_S133\n", + "i_search = 4\n", + "Looking for paths with length: 4 for node MAPK14_Y182 and CREB1_S133\n", + "looking for paths in the network with length: 0 for node MAPK14_Y182 and NFKBIA_S32\n", + "looking for paths in the network with length: 1 for node MAPK14_Y182 and NFKBIA_S32\n", + "looking for paths in the network with length: 2 for node MAPK14_Y182 and NFKBIA_S32\n", + "looking for paths in the network with length: 3 for node MAPK14_Y182 and NFKBIA_S32\n", + "looking for paths in the network with length: 4 for node MAPK14_Y182 and NFKBIA_S32\n", + "looking for paths in the network with length: 5 for node MAPK14_Y182 and NFKBIA_S32\n", + "looking for paths in the network with length: 6 for node MAPK14_Y182 and NFKBIA_S32\n", + "looking for paths in the network with length: 7 for node MAPK14_Y182 and NFKBIA_S32\n", + "looking for paths in the network with length: 8 for node MAPK14_Y182 and NFKBIA_S32\n", + "Found a path!\n", + "[['MAPK14_Y182', 'MAPK14', 'MAPKAPK2_S272', 'MAPKAPK2', 'AKT1_S473', 'AKT1', 'RPS6KA3_S19', 'RPS6KA3', 'NFKBIA_S32'], ['MAPK14_Y182', 'MAPK14', 'MAPKAPK2_S272', 'MAPKAPK2', 'AKT1_S473', 'AKT1', 'CHUK_T23', 'CHUK', 'NFKBIA_S32'], ['MAPK14_Y182', 'MAPK14', 'MAPKAPK2_T222', 'MAPKAPK2', 'AKT1_S473', 'AKT1', 'RPS6KA3_S19', 'RPS6KA3', 'NFKBIA_S32'], ['MAPK14_Y182', 'MAPK14', 'MAPKAPK2_T222', 'MAPKAPK2', 'AKT1_S473', 'AKT1', 'CHUK_T23', 'CHUK', 'NFKBIA_S32'], ['MAPK14_Y182', 'MAPK14', 'MAPKAPK2_T334', 'MAPKAPK2', 'AKT1_S473', 'AKT1', 'RPS6KA3_S19', 'RPS6KA3', 'NFKBIA_S32'], ['MAPK14_Y182', 'MAPK14', 'MAPKAPK2_T334', 'MAPKAPK2', 'AKT1_S473', 'AKT1', 'CHUK_T23', 'CHUK', 'NFKBIA_S32']]\n", + "looking for paths in the network with length: 0 for node MAPK14_Y182 and NFKBIA_S36\n", + "looking for paths in the network with length: 1 for node MAPK14_Y182 and NFKBIA_S36\n", + "looking for paths in the network with length: 2 for node MAPK14_Y182 and NFKBIA_S36\n", + "looking for paths in the network with length: 3 for node MAPK14_Y182 and NFKBIA_S36\n", + "looking for paths in the network with length: 4 for node MAPK14_Y182 and NFKBIA_S36\n", + "looking for paths in the network with length: 5 for node MAPK14_Y182 and NFKBIA_S36\n", + "looking for paths in the network with length: 6 for node MAPK14_Y182 and NFKBIA_S36\n", + "looking for paths in the network with length: 7 for node MAPK14_Y182 and NFKBIA_S36\n", + "looking for paths in the network with length: 8 for node MAPK14_Y182 and NFKBIA_S36\n", + "Found a path!\n", + "[['MAPK14_Y182', 'MAPK14', 'MAPKAPK2_S272', 'MAPKAPK2', 'AKT1_S473', 'AKT1', 'CHUK_T23', 'CHUK', 'NFKBIA_S36'], ['MAPK14_Y182', 'MAPK14', 'MAPKAPK2_T222', 'MAPKAPK2', 'AKT1_S473', 'AKT1', 'CHUK_T23', 'CHUK', 'NFKBIA_S36'], ['MAPK14_Y182', 'MAPK14', 'MAPKAPK2_T334', 'MAPKAPK2', 'AKT1_S473', 'AKT1', 'CHUK_T23', 'CHUK', 'NFKBIA_S36']]\n", + "looking for paths in the network with length: 0 for node MAPK14_Y182 and MTOR_S2448\n", + "looking for paths in the network with length: 1 for node MAPK14_Y182 and MTOR_S2448\n", + "looking for paths in the network with length: 2 for node MAPK14_Y182 and MTOR_S2448\n", + "looking for paths in the network with length: 3 for node MAPK14_Y182 and MTOR_S2448\n", + "looking for paths in the network with length: 4 for node MAPK14_Y182 and MTOR_S2448\n", + "looking for paths in the network with length: 5 for node MAPK14_Y182 and MTOR_S2448\n", + "looking for paths in the network with length: 6 for node MAPK14_Y182 and MTOR_S2448\n", + "Found a path!\n", + "[['MAPK14_Y182', 'MAPK14', 'MAPKAPK2_S272', 'MAPKAPK2', 'AKT1_S473', 'AKT1', 'MTOR_S2448'], ['MAPK14_Y182', 'MAPK14', 'MAPKAPK2_T222', 'MAPKAPK2', 'AKT1_S473', 'AKT1', 'MTOR_S2448'], ['MAPK14_Y182', 'MAPK14', 'MAPKAPK2_T334', 'MAPKAPK2', 'AKT1_S473', 'AKT1', 'MTOR_S2448']]\n", + "looking for paths in the network with length: 0 for node MAPK14_Y182 and JUN_S63\n", + "looking for paths in the network with length: 1 for node MAPK14_Y182 and JUN_S63\n", + "looking for paths in the network with length: 2 for node MAPK14_Y182 and JUN_S63\n", + "looking for paths in the network with length: 3 for node MAPK14_Y182 and JUN_S63\n", + "looking for paths in the network with length: 4 for node MAPK14_Y182 and JUN_S63\n", + "looking for paths in the network with length: 5 for node MAPK14_Y182 and JUN_S63\n", + "looking for paths in the network with length: 6 for node MAPK14_Y182 and JUN_S63\n", + "looking for paths in the network with length: 7 for node MAPK14_Y182 and JUN_S63\n", + "looking for paths in the network with length: 8 for node MAPK14_Y182 and JUN_S63\n", + "looking for paths in the network with length: 9 for node MAPK14_Y182 and JUN_S63\n", + "looking for paths in the network with length: 10 for node MAPK14_Y182 and JUN_S63\n", + "i_search = 4\n", + "Looking for paths with length: 0 for node MAPK14_Y182 and JUN_S63\n", + "i_search = 4\n", + "Looking for paths with length: 1 for node MAPK14_Y182 and JUN_S63\n", + "i_search = 4\n", + "Looking for paths with length: 2 for node MAPK14_Y182 and JUN_S63\n", + "i_search = 4\n", + "Looking for paths with length: 3 for node MAPK14_Y182 and JUN_S63\n", + "i_search = 4\n", + "Looking for paths with length: 4 for node MAPK14_Y182 and JUN_S63\n", + "looking for paths in the network with length: 0 for node MAPK14_Y182 and EGFR_Y1068\n", + "looking for paths in the network with length: 1 for node MAPK14_Y182 and EGFR_Y1068\n", + "looking for paths in the network with length: 2 for node MAPK14_Y182 and EGFR_Y1068\n", + "looking for paths in the network with length: 3 for node MAPK14_Y182 and EGFR_Y1068\n", + "looking for paths in the network with length: 4 for node MAPK14_Y182 and EGFR_Y1068\n", + "looking for paths in the network with length: 5 for node MAPK14_Y182 and EGFR_Y1068\n", + "looking for paths in the network with length: 6 for node MAPK14_Y182 and EGFR_Y1068\n", + "looking for paths in the network with length: 7 for node MAPK14_Y182 and EGFR_Y1068\n", + "looking for paths in the network with length: 8 for node MAPK14_Y182 and EGFR_Y1068\n", + "looking for paths in the network with length: 9 for node MAPK14_Y182 and EGFR_Y1068\n", + "looking for paths in the network with length: 10 for node MAPK14_Y182 and EGFR_Y1068\n", + "i_search = 4\n", + "Looking for paths with length: 0 for node MAPK14_Y182 and EGFR_Y1068\n", + "i_search = 4\n", + "Looking for paths with length: 1 for node MAPK14_Y182 and EGFR_Y1068\n", + "i_search = 4\n", + "Looking for paths with length: 2 for node MAPK14_Y182 and EGFR_Y1068\n", + "i_search = 4\n", + "Looking for paths with length: 3 for node MAPK14_Y182 and EGFR_Y1068\n", + "i_search = 4\n", + "Looking for paths with length: 4 for node MAPK14_Y182 and EGFR_Y1068\n", + "looking for paths in the network with length: 0 for node MAPK14_Y182 and MAPK3_T202\n", + "looking for paths in the network with length: 1 for node MAPK14_Y182 and MAPK3_T202\n", + "looking for paths in the network with length: 2 for node MAPK14_Y182 and MAPK3_T202\n", + "looking for paths in the network with length: 3 for node MAPK14_Y182 and MAPK3_T202\n", + "looking for paths in the network with length: 4 for node MAPK14_Y182 and MAPK3_T202\n", + "looking for paths in the network with length: 5 for node MAPK14_Y182 and MAPK3_T202\n", + "looking for paths in the network with length: 6 for node MAPK14_Y182 and MAPK3_T202\n", + "looking for paths in the network with length: 7 for node MAPK14_Y182 and MAPK3_T202\n", + "looking for paths in the network with length: 8 for node MAPK14_Y182 and MAPK3_T202\n", + "looking for paths in the network with length: 9 for node MAPK14_Y182 and MAPK3_T202\n", + "looking for paths in the network with length: 10 for node MAPK14_Y182 and MAPK3_T202\n", + "Found a path!\n", + "[['MAPK14_Y182', 'MAPK14', 'MAPKAPK2_S272', 'MAPKAPK2', 'AKT1_S473', 'AKT1', 'RAF1_S259', 'RAF1', 'MAP2K1_S222', 'MAP2K1', 'MAPK3_T202'], ['MAPK14_Y182', 'MAPK14', 'MAPKAPK2_S272', 'MAPKAPK2', 'AKT1_S473', 'AKT1', 'RAF1_S259', 'RAF1', 'MAP2K1_S218', 'MAP2K1', 'MAPK3_T202'], ['MAPK14_Y182', 'MAPK14', 'MAPKAPK2_S272', 'MAPKAPK2', 'AKT1_S473', 'AKT1', 'BRAF_S429', 'BRAF', 'MAP2K1_S222', 'MAP2K1', 'MAPK3_T202'], ['MAPK14_Y182', 'MAPK14', 'MAPKAPK2_S272', 'MAPKAPK2', 'AKT1_S473', 'AKT1', 'BRAF_S429', 'BRAF', 'MAP2K1_S218', 'MAP2K1', 'MAPK3_T202'], ['MAPK14_Y182', 'MAPK14', 'MAPKAPK2_S272', 'MAPKAPK2', 'AKT1_S473', 'AKT1', 'BRAF_S365', 'BRAF', 'MAP2K1_S222', 'MAP2K1', 'MAPK3_T202'], ['MAPK14_Y182', 'MAPK14', 'MAPKAPK2_S272', 'MAPKAPK2', 'AKT1_S473', 'AKT1', 'BRAF_S365', 'BRAF', 'MAP2K1_S218', 'MAP2K1', 'MAPK3_T202'], ['MAPK14_Y182', 'MAPK14', 'MAPKAPK2_T222', 'MAPKAPK2', 'AKT1_S473', 'AKT1', 'RAF1_S259', 'RAF1', 'MAP2K1_S222', 'MAP2K1', 'MAPK3_T202'], ['MAPK14_Y182', 'MAPK14', 'MAPKAPK2_T222', 'MAPKAPK2', 'AKT1_S473', 'AKT1', 'RAF1_S259', 'RAF1', 'MAP2K1_S218', 'MAP2K1', 'MAPK3_T202'], ['MAPK14_Y182', 'MAPK14', 'MAPKAPK2_T222', 'MAPKAPK2', 'AKT1_S473', 'AKT1', 'BRAF_S429', 'BRAF', 'MAP2K1_S222', 'MAP2K1', 'MAPK3_T202'], ['MAPK14_Y182', 'MAPK14', 'MAPKAPK2_T222', 'MAPKAPK2', 'AKT1_S473', 'AKT1', 'BRAF_S429', 'BRAF', 'MAP2K1_S218', 'MAP2K1', 'MAPK3_T202'], ['MAPK14_Y182', 'MAPK14', 'MAPKAPK2_T222', 'MAPKAPK2', 'AKT1_S473', 'AKT1', 'BRAF_S365', 'BRAF', 'MAP2K1_S222', 'MAP2K1', 'MAPK3_T202'], ['MAPK14_Y182', 'MAPK14', 'MAPKAPK2_T222', 'MAPKAPK2', 'AKT1_S473', 'AKT1', 'BRAF_S365', 'BRAF', 'MAP2K1_S218', 'MAP2K1', 'MAPK3_T202'], ['MAPK14_Y182', 'MAPK14', 'MAPKAPK2_T334', 'MAPKAPK2', 'AKT1_S473', 'AKT1', 'RAF1_S259', 'RAF1', 'MAP2K1_S222', 'MAP2K1', 'MAPK3_T202'], ['MAPK14_Y182', 'MAPK14', 'MAPKAPK2_T334', 'MAPKAPK2', 'AKT1_S473', 'AKT1', 'RAF1_S259', 'RAF1', 'MAP2K1_S218', 'MAP2K1', 'MAPK3_T202'], ['MAPK14_Y182', 'MAPK14', 'MAPKAPK2_T334', 'MAPKAPK2', 'AKT1_S473', 'AKT1', 'BRAF_S429', 'BRAF', 'MAP2K1_S222', 'MAP2K1', 'MAPK3_T202'], ['MAPK14_Y182', 'MAPK14', 'MAPKAPK2_T334', 'MAPKAPK2', 'AKT1_S473', 'AKT1', 'BRAF_S429', 'BRAF', 'MAP2K1_S218', 'MAP2K1', 'MAPK3_T202'], ['MAPK14_Y182', 'MAPK14', 'MAPKAPK2_T334', 'MAPKAPK2', 'AKT1_S473', 'AKT1', 'BRAF_S365', 'BRAF', 'MAP2K1_S222', 'MAP2K1', 'MAPK3_T202'], ['MAPK14_Y182', 'MAPK14', 'MAPKAPK2_T334', 'MAPKAPK2', 'AKT1_S473', 'AKT1', 'BRAF_S365', 'BRAF', 'MAP2K1_S218', 'MAP2K1', 'MAPK3_T202']]\n", + "looking for paths in the network with length: 0 for node MAPK14_Y182 and MAPK3_Y204\n", + "looking for paths in the network with length: 1 for node MAPK14_Y182 and MAPK3_Y204\n", + "looking for paths in the network with length: 2 for node MAPK14_Y182 and MAPK3_Y204\n", + "looking for paths in the network with length: 3 for node MAPK14_Y182 and MAPK3_Y204\n", + "looking for paths in the network with length: 4 for node MAPK14_Y182 and MAPK3_Y204\n", + "looking for paths in the network with length: 5 for node MAPK14_Y182 and MAPK3_Y204\n", + "looking for paths in the network with length: 6 for node MAPK14_Y182 and MAPK3_Y204\n", + "looking for paths in the network with length: 7 for node MAPK14_Y182 and MAPK3_Y204\n", + "looking for paths in the network with length: 8 for node MAPK14_Y182 and MAPK3_Y204\n", + "looking for paths in the network with length: 9 for node MAPK14_Y182 and MAPK3_Y204\n", + "looking for paths in the network with length: 10 for node MAPK14_Y182 and MAPK3_Y204\n", + "Found a path!\n", + "[['MAPK14_Y182', 'MAPK14', 'MAPKAPK2_S272', 'MAPKAPK2', 'AKT1_S473', 'AKT1', 'RAF1_S259', 'RAF1', 'MAP2K1_S222', 'MAP2K1', 'MAPK3_Y204'], ['MAPK14_Y182', 'MAPK14', 'MAPKAPK2_S272', 'MAPKAPK2', 'AKT1_S473', 'AKT1', 'RAF1_S259', 'RAF1', 'MAP2K1_S218', 'MAP2K1', 'MAPK3_Y204'], ['MAPK14_Y182', 'MAPK14', 'MAPKAPK2_S272', 'MAPKAPK2', 'AKT1_S473', 'AKT1', 'BRAF_S429', 'BRAF', 'MAP2K1_S222', 'MAP2K1', 'MAPK3_Y204'], ['MAPK14_Y182', 'MAPK14', 'MAPKAPK2_S272', 'MAPKAPK2', 'AKT1_S473', 'AKT1', 'BRAF_S429', 'BRAF', 'MAP2K1_S218', 'MAP2K1', 'MAPK3_Y204'], ['MAPK14_Y182', 'MAPK14', 'MAPKAPK2_S272', 'MAPKAPK2', 'AKT1_S473', 'AKT1', 'BRAF_S365', 'BRAF', 'MAP2K1_S222', 'MAP2K1', 'MAPK3_Y204'], ['MAPK14_Y182', 'MAPK14', 'MAPKAPK2_S272', 'MAPKAPK2', 'AKT1_S473', 'AKT1', 'BRAF_S365', 'BRAF', 'MAP2K1_S218', 'MAP2K1', 'MAPK3_Y204'], ['MAPK14_Y182', 'MAPK14', 'MAPKAPK2_T222', 'MAPKAPK2', 'AKT1_S473', 'AKT1', 'RAF1_S259', 'RAF1', 'MAP2K1_S222', 'MAP2K1', 'MAPK3_Y204'], ['MAPK14_Y182', 'MAPK14', 'MAPKAPK2_T222', 'MAPKAPK2', 'AKT1_S473', 'AKT1', 'RAF1_S259', 'RAF1', 'MAP2K1_S218', 'MAP2K1', 'MAPK3_Y204'], ['MAPK14_Y182', 'MAPK14', 'MAPKAPK2_T222', 'MAPKAPK2', 'AKT1_S473', 'AKT1', 'BRAF_S429', 'BRAF', 'MAP2K1_S222', 'MAP2K1', 'MAPK3_Y204'], ['MAPK14_Y182', 'MAPK14', 'MAPKAPK2_T222', 'MAPKAPK2', 'AKT1_S473', 'AKT1', 'BRAF_S429', 'BRAF', 'MAP2K1_S218', 'MAP2K1', 'MAPK3_Y204'], ['MAPK14_Y182', 'MAPK14', 'MAPKAPK2_T222', 'MAPKAPK2', 'AKT1_S473', 'AKT1', 'BRAF_S365', 'BRAF', 'MAP2K1_S222', 'MAP2K1', 'MAPK3_Y204'], ['MAPK14_Y182', 'MAPK14', 'MAPKAPK2_T222', 'MAPKAPK2', 'AKT1_S473', 'AKT1', 'BRAF_S365', 'BRAF', 'MAP2K1_S218', 'MAP2K1', 'MAPK3_Y204'], ['MAPK14_Y182', 'MAPK14', 'MAPKAPK2_T334', 'MAPKAPK2', 'AKT1_S473', 'AKT1', 'RAF1_S259', 'RAF1', 'MAP2K1_S222', 'MAP2K1', 'MAPK3_Y204'], ['MAPK14_Y182', 'MAPK14', 'MAPKAPK2_T334', 'MAPKAPK2', 'AKT1_S473', 'AKT1', 'RAF1_S259', 'RAF1', 'MAP2K1_S218', 'MAP2K1', 'MAPK3_Y204'], ['MAPK14_Y182', 'MAPK14', 'MAPKAPK2_T334', 'MAPKAPK2', 'AKT1_S473', 'AKT1', 'BRAF_S429', 'BRAF', 'MAP2K1_S222', 'MAP2K1', 'MAPK3_Y204'], ['MAPK14_Y182', 'MAPK14', 'MAPKAPK2_T334', 'MAPKAPK2', 'AKT1_S473', 'AKT1', 'BRAF_S429', 'BRAF', 'MAP2K1_S218', 'MAP2K1', 'MAPK3_Y204'], ['MAPK14_Y182', 'MAPK14', 'MAPKAPK2_T334', 'MAPKAPK2', 'AKT1_S473', 'AKT1', 'BRAF_S365', 'BRAF', 'MAP2K1_S222', 'MAP2K1', 'MAPK3_Y204'], ['MAPK14_Y182', 'MAPK14', 'MAPKAPK2_T334', 'MAPKAPK2', 'AKT1_S473', 'AKT1', 'BRAF_S365', 'BRAF', 'MAP2K1_S218', 'MAP2K1', 'MAPK3_Y204']]\n", + "looking for paths in the network with length: 0 for node MAPK14_Y182 and PTPN11_Y542\n", + "looking for paths in the network with length: 1 for node MAPK14_Y182 and PTPN11_Y542\n", + "looking for paths in the network with length: 2 for node MAPK14_Y182 and PTPN11_Y542\n", + "looking for paths in the network with length: 3 for node MAPK14_Y182 and PTPN11_Y542\n", + "looking for paths in the network with length: 4 for node MAPK14_Y182 and PTPN11_Y542\n", + "looking for paths in the network with length: 5 for node MAPK14_Y182 and PTPN11_Y542\n", + "looking for paths in the network with length: 6 for node MAPK14_Y182 and PTPN11_Y542\n", + "looking for paths in the network with length: 7 for node MAPK14_Y182 and PTPN11_Y542\n", + "looking for paths in the network with length: 8 for node MAPK14_Y182 and PTPN11_Y542\n", + "looking for paths in the network with length: 9 for node MAPK14_Y182 and PTPN11_Y542\n", + "looking for paths in the network with length: 10 for node MAPK14_Y182 and PTPN11_Y542\n", + "i_search = 4\n", + "Looking for paths with length: 0 for node MAPK14_Y182 and PTPN11_Y542\n", + "i_search = 4\n", + "Looking for paths with length: 1 for node MAPK14_Y182 and PTPN11_Y542\n", + "i_search = 4\n", + "Looking for paths with length: 2 for node MAPK14_Y182 and PTPN11_Y542\n", + "i_search = 4\n", + "Looking for paths with length: 3 for node MAPK14_Y182 and PTPN11_Y542\n", + "i_search = 4\n", + "Looking for paths with length: 4 for node MAPK14_Y182 and PTPN11_Y542\n", + "looking for paths in the network with length: 0 for node MAPK14_Y182 and STAT3_Y705\n", + "looking for paths in the network with length: 1 for node MAPK14_Y182 and STAT3_Y705\n", + "looking for paths in the network with length: 2 for node MAPK14_Y182 and STAT3_Y705\n", + "looking for paths in the network with length: 3 for node MAPK14_Y182 and STAT3_Y705\n", + "looking for paths in the network with length: 4 for node MAPK14_Y182 and STAT3_Y705\n", + "looking for paths in the network with length: 5 for node MAPK14_Y182 and STAT3_Y705\n", + "looking for paths in the network with length: 6 for node MAPK14_Y182 and STAT3_Y705\n", + "Found a path!\n", + "[['MAPK14_Y182', 'MAPK14', 'GSK3B_T390', 'GSK3B', 'SRC_S493', 'SRC', 'STAT3_Y705'], ['MAPK14_Y182', 'MAPK14', 'GSK3B_T390', 'GSK3B', 'SRC_S51', 'SRC', 'STAT3_Y705'], ['MAPK14_Y182', 'MAPK14', 'GSK3B_T390', 'GSK3B', 'SRC_S43', 'SRC', 'STAT3_Y705'], ['MAPK14_Y182', 'MAPK14', 'GSK3B_T390', 'GSK3B', 'SRC_Y419', 'SRC', 'STAT3_Y705'], ['MAPK14_Y182', 'MAPK14', 'GSK3B_T43', 'GSK3B', 'SRC_S493', 'SRC', 'STAT3_Y705'], ['MAPK14_Y182', 'MAPK14', 'GSK3B_T43', 'GSK3B', 'SRC_S51', 'SRC', 'STAT3_Y705'], ['MAPK14_Y182', 'MAPK14', 'GSK3B_T43', 'GSK3B', 'SRC_S43', 'SRC', 'STAT3_Y705'], ['MAPK14_Y182', 'MAPK14', 'GSK3B_T43', 'GSK3B', 'SRC_Y419', 'SRC', 'STAT3_Y705']]\n", + "looking for paths in the network with length: 0 for node MAPK14_Y182 and CHEK2_T68\n", + "looking for paths in the network with length: 1 for node MAPK14_Y182 and CHEK2_T68\n", + "looking for paths in the network with length: 2 for node MAPK14_Y182 and CHEK2_T68\n", + "looking for paths in the network with length: 3 for node MAPK14_Y182 and CHEK2_T68\n", + "looking for paths in the network with length: 4 for node MAPK14_Y182 and CHEK2_T68\n", + "looking for paths in the network with length: 5 for node MAPK14_Y182 and CHEK2_T68\n", + "looking for paths in the network with length: 6 for node MAPK14_Y182 and CHEK2_T68\n", + "looking for paths in the network with length: 7 for node MAPK14_Y182 and CHEK2_T68\n", + "looking for paths in the network with length: 8 for node MAPK14_Y182 and CHEK2_T68\n", + "looking for paths in the network with length: 9 for node MAPK14_Y182 and CHEK2_T68\n", + "looking for paths in the network with length: 10 for node MAPK14_Y182 and CHEK2_T68\n", + "i_search = 4\n", + "Looking for paths with length: 0 for node MAPK14_Y182 and CHEK2_T68\n", + "i_search = 4\n", + "Looking for paths with length: 1 for node MAPK14_Y182 and CHEK2_T68\n", + "i_search = 4\n", + "Looking for paths with length: 2 for node MAPK14_Y182 and CHEK2_T68\n", + "i_search = 4\n", + "Looking for paths with length: 3 for node MAPK14_Y182 and CHEK2_T68\n", + "i_search = 4\n", + "Looking for paths with length: 4 for node MAPK14_Y182 and CHEK2_T68\n", + "looking for paths in the network with length: 0 for node MAPK14_Y182 and RELA_S536\n", + "looking for paths in the network with length: 1 for node MAPK14_Y182 and RELA_S536\n", + "looking for paths in the network with length: 2 for node MAPK14_Y182 and RELA_S536\n", + "looking for paths in the network with length: 3 for node MAPK14_Y182 and RELA_S536\n", + "looking for paths in the network with length: 4 for node MAPK14_Y182 and RELA_S536\n", + "looking for paths in the network with length: 5 for node MAPK14_Y182 and RELA_S536\n", + "looking for paths in the network with length: 6 for node MAPK14_Y182 and RELA_S536\n", + "Found a path!\n", + "[['MAPK14_Y182', 'MAPK14', 'GSK3B_T390', 'GSK3B', 'TBK1_S172', 'TBK1', 'RELA_S536'], ['MAPK14_Y182', 'MAPK14', 'GSK3B_T43', 'GSK3B', 'TBK1_S172', 'TBK1', 'RELA_S536']]\n", + "looking for paths in the network with length: 0 for node MAPK14_Y182 and MARCKS_S170\n", + "looking for paths in the network with length: 1 for node MAPK14_Y182 and MARCKS_S170\n", + "looking for paths in the network with length: 2 for node MAPK14_Y182 and MARCKS_S170\n", + "looking for paths in the network with length: 3 for node MAPK14_Y182 and MARCKS_S170\n", + "looking for paths in the network with length: 4 for node MAPK14_Y182 and MARCKS_S170\n", + "looking for paths in the network with length: 5 for node MAPK14_Y182 and MARCKS_S170\n", + "looking for paths in the network with length: 6 for node MAPK14_Y182 and MARCKS_S170\n", + "looking for paths in the network with length: 7 for node MAPK14_Y182 and MARCKS_S170\n", + "looking for paths in the network with length: 8 for node MAPK14_Y182 and MARCKS_S170\n", + "looking for paths in the network with length: 9 for node MAPK14_Y182 and MARCKS_S170\n", + "looking for paths in the network with length: 10 for node MAPK14_Y182 and MARCKS_S170\n", + "i_search = 4\n", + "Looking for paths with length: 0 for node MAPK14_Y182 and MARCKS_S170\n", + "i_search = 4\n", + "Looking for paths with length: 1 for node MAPK14_Y182 and MARCKS_S170\n", + "i_search = 4\n", + "Looking for paths with length: 2 for node MAPK14_Y182 and MARCKS_S170\n", + "i_search = 4\n", + "Looking for paths with length: 3 for node MAPK14_Y182 and MARCKS_S170\n", + "i_search = 4\n", + "Looking for paths with length: 4 for node MAPK14_Y182 and MARCKS_S170\n", + "looking for paths in the network with length: 0 for node MAPK14_Y182 and SMAD3\n", + "looking for paths in the network with length: 1 for node MAPK14_Y182 and SMAD3\n", + "looking for paths in the network with length: 2 for node MAPK14_Y182 and SMAD3\n", + "looking for paths in the network with length: 3 for node MAPK14_Y182 and SMAD3\n", + "looking for paths in the network with length: 4 for node MAPK14_Y182 and SMAD3\n", + "looking for paths in the network with length: 5 for node MAPK14_Y182 and SMAD3\n", + "looking for paths in the network with length: 6 for node MAPK14_Y182 and SMAD3\n", + "looking for paths in the network with length: 7 for node MAPK14_Y182 and SMAD3\n", + "looking for paths in the network with length: 8 for node MAPK14_Y182 and SMAD3\n", + "looking for paths in the network with length: 9 for node MAPK14_Y182 and SMAD3\n", + "looking for paths in the network with length: 10 for node MAPK14_Y182 and SMAD3\n", + "i_search = 4\n", + "Looking for paths with length: 0 for node MAPK14_Y182 and SMAD3\n", + "i_search = 4\n", + "Looking for paths with length: 1 for node MAPK14_Y182 and SMAD3\n", + "i_search = 4\n", + "Looking for paths with length: 2 for node MAPK14_Y182 and SMAD3\n", + "i_search = 4\n", + "Looking for paths with length: 3 for node MAPK14_Y182 and SMAD3\n", + "i_search = 4\n", + "Looking for paths with length: 4 for node MAPK14_Y182 and SMAD3\n", + "looking for paths in the network with length: 0 for node MAPK14_Y182 and TP53\n", + "looking for paths in the network with length: 1 for node MAPK14_Y182 and TP53\n", + "looking for paths in the network with length: 2 for node MAPK14_Y182 and TP53\n", + "looking for paths in the network with length: 3 for node MAPK14_Y182 and TP53\n", + "looking for paths in the network with length: 4 for node MAPK14_Y182 and TP53\n", + "looking for paths in the network with length: 5 for node MAPK14_Y182 and TP53\n", + "looking for paths in the network with length: 6 for node MAPK14_Y182 and TP53\n", + "looking for paths in the network with length: 7 for node MAPK14_Y182 and TP53\n", + "looking for paths in the network with length: 8 for node MAPK14_Y182 and TP53\n", + "looking for paths in the network with length: 9 for node MAPK14_Y182 and TP53\n", + "looking for paths in the network with length: 10 for node MAPK14_Y182 and TP53\n", + "i_search = 4\n", + "Looking for paths with length: 0 for node MAPK14_Y182 and TP53\n", + "i_search = 4\n", + "Looking for paths with length: 1 for node MAPK14_Y182 and TP53\n", + "i_search = 4\n", + "Looking for paths with length: 2 for node MAPK14_Y182 and TP53\n", + "i_search = 4\n", + "Looking for paths with length: 3 for node MAPK14_Y182 and TP53\n", + "i_search = 4\n", + "Looking for paths with length: 4 for node MAPK14_Y182 and TP53\n", + "looking for paths in the network with length: 0 for node MAPK14_Y182 and AKT1S1\n", + "looking for paths in the network with length: 1 for node MAPK14_Y182 and AKT1S1\n", + "looking for paths in the network with length: 2 for node MAPK14_Y182 and AKT1S1\n", + "looking for paths in the network with length: 3 for node MAPK14_Y182 and AKT1S1\n", + "looking for paths in the network with length: 4 for node MAPK14_Y182 and AKT1S1\n", + "looking for paths in the network with length: 5 for node MAPK14_Y182 and AKT1S1\n", + "looking for paths in the network with length: 6 for node MAPK14_Y182 and AKT1S1\n", + "looking for paths in the network with length: 7 for node MAPK14_Y182 and AKT1S1\n", + "looking for paths in the network with length: 8 for node MAPK14_Y182 and AKT1S1\n", + "looking for paths in the network with length: 9 for node MAPK14_Y182 and AKT1S1\n", + "looking for paths in the network with length: 10 for node MAPK14_Y182 and AKT1S1\n", + "i_search = 4\n", + "Looking for paths with length: 0 for node MAPK14_Y182 and AKT1S1\n", + "i_search = 4\n", + "Looking for paths with length: 1 for node MAPK14_Y182 and AKT1S1\n", + "i_search = 4\n", + "Looking for paths with length: 2 for node MAPK14_Y182 and AKT1S1\n", + "i_search = 4\n", + "Looking for paths with length: 3 for node MAPK14_Y182 and AKT1S1\n", + "i_search = 4\n", + "Looking for paths with length: 4 for node MAPK14_Y182 and AKT1S1\n", + "looking for paths in the network with length: 0 for node MAPK14_Y182 and GSK3B\n", + "looking for paths in the network with length: 1 for node MAPK14_Y182 and GSK3B\n", + "looking for paths in the network with length: 2 for node MAPK14_Y182 and GSK3B\n", + "looking for paths in the network with length: 3 for node MAPK14_Y182 and GSK3B\n", + "looking for paths in the network with length: 4 for node MAPK14_Y182 and GSK3B\n", + "looking for paths in the network with length: 5 for node MAPK14_Y182 and GSK3B\n", + "looking for paths in the network with length: 6 for node MAPK14_Y182 and GSK3B\n", + "looking for paths in the network with length: 7 for node MAPK14_Y182 and GSK3B\n", + "looking for paths in the network with length: 8 for node MAPK14_Y182 and GSK3B\n", + "looking for paths in the network with length: 9 for node MAPK14_Y182 and GSK3B\n", + "looking for paths in the network with length: 10 for node MAPK14_Y182 and GSK3B\n", + "i_search = 4\n", + "Looking for paths with length: 0 for node MAPK14_Y182 and GSK3B\n", + "i_search = 4\n", + "Looking for paths with length: 1 for node MAPK14_Y182 and GSK3B\n", + "i_search = 4\n", + "Looking for paths with length: 2 for node MAPK14_Y182 and GSK3B\n", + "i_search = 4\n", + "Looking for paths with length: 3 for node MAPK14_Y182 and GSK3B\n", + "i_search = 4\n", + "Looking for paths with length: 4 for node MAPK14_Y182 and GSK3B\n", + "looking for paths in the network with length: 0 for node MAPK14_Y182 and AKT1\n", + "looking for paths in the network with length: 1 for node MAPK14_Y182 and AKT1\n", + "looking for paths in the network with length: 2 for node MAPK14_Y182 and AKT1\n", + "looking for paths in the network with length: 3 for node MAPK14_Y182 and AKT1\n", + "looking for paths in the network with length: 4 for node MAPK14_Y182 and AKT1\n", + "looking for paths in the network with length: 5 for node MAPK14_Y182 and AKT1\n", + "looking for paths in the network with length: 6 for node MAPK14_Y182 and AKT1\n", + "looking for paths in the network with length: 7 for node MAPK14_Y182 and AKT1\n", + "looking for paths in the network with length: 8 for node MAPK14_Y182 and AKT1\n", + "looking for paths in the network with length: 9 for node MAPK14_Y182 and AKT1\n", + "looking for paths in the network with length: 10 for node MAPK14_Y182 and AKT1\n", + "i_search = 4\n", + "Looking for paths with length: 0 for node MAPK14_Y182 and AKT1\n", + "i_search = 4\n", + "Looking for paths with length: 1 for node MAPK14_Y182 and AKT1\n", + "i_search = 4\n", + "Looking for paths with length: 2 for node MAPK14_Y182 and AKT1\n", + "i_search = 4\n", + "Looking for paths with length: 3 for node MAPK14_Y182 and AKT1\n", + "i_search = 4\n", + "Looking for paths with length: 4 for node MAPK14_Y182 and AKT1\n", + "looking for paths in the network with length: 0 for node MAPK14_Y182 and HSPB1\n", + "looking for paths in the network with length: 1 for node MAPK14_Y182 and HSPB1\n", + "looking for paths in the network with length: 2 for node MAPK14_Y182 and HSPB1\n", + "looking for paths in the network with length: 3 for node MAPK14_Y182 and HSPB1\n", + "looking for paths in the network with length: 4 for node MAPK14_Y182 and HSPB1\n", + "looking for paths in the network with length: 5 for node MAPK14_Y182 and HSPB1\n", + "looking for paths in the network with length: 6 for node MAPK14_Y182 and HSPB1\n", + "looking for paths in the network with length: 7 for node MAPK14_Y182 and HSPB1\n", + "looking for paths in the network with length: 8 for node MAPK14_Y182 and HSPB1\n", + "looking for paths in the network with length: 9 for node MAPK14_Y182 and HSPB1\n", + "looking for paths in the network with length: 10 for node MAPK14_Y182 and HSPB1\n", + "i_search = 4\n", + "Looking for paths with length: 0 for node MAPK14_Y182 and HSPB1\n", + "i_search = 4\n", + "Looking for paths with length: 1 for node MAPK14_Y182 and HSPB1\n", + "i_search = 4\n", + "Looking for paths with length: 2 for node MAPK14_Y182 and HSPB1\n", + "i_search = 4\n", + "Looking for paths with length: 3 for node MAPK14_Y182 and HSPB1\n", + "i_search = 4\n", + "Looking for paths with length: 4 for node MAPK14_Y182 and HSPB1\n", + "looking for paths in the network with length: 0 for node MAPK14_Y182 and MAPK14\n", + "looking for paths in the network with length: 1 for node MAPK14_Y182 and MAPK14\n", + "looking for paths in the network with length: 2 for node MAPK14_Y182 and MAPK14\n", + "looking for paths in the network with length: 3 for node MAPK14_Y182 and MAPK14\n", + "looking for paths in the network with length: 4 for node MAPK14_Y182 and MAPK14\n", + "looking for paths in the network with length: 5 for node MAPK14_Y182 and MAPK14\n", + "looking for paths in the network with length: 6 for node MAPK14_Y182 and MAPK14\n", + "looking for paths in the network with length: 7 for node MAPK14_Y182 and MAPK14\n", + "looking for paths in the network with length: 8 for node MAPK14_Y182 and MAPK14\n", + "looking for paths in the network with length: 9 for node MAPK14_Y182 and MAPK14\n", + "looking for paths in the network with length: 10 for node MAPK14_Y182 and MAPK14\n", + "i_search = 4\n", + "Looking for paths with length: 0 for node MAPK14_Y182 and MAPK14\n", + "i_search = 4\n", + "Looking for paths with length: 1 for node MAPK14_Y182 and MAPK14\n", + "i_search = 4\n", + "Looking for paths with length: 2 for node MAPK14_Y182 and MAPK14\n", + "i_search = 4\n", + "Looking for paths with length: 3 for node MAPK14_Y182 and MAPK14\n", + "i_search = 4\n", + "Looking for paths with length: 4 for node MAPK14_Y182 and MAPK14\n", + "looking for paths in the network with length: 0 for node MAPK14_Y182 and MAP2K1\n", + "looking for paths in the network with length: 1 for node MAPK14_Y182 and MAP2K1\n", + "looking for paths in the network with length: 2 for node MAPK14_Y182 and MAP2K1\n", + "looking for paths in the network with length: 3 for node MAPK14_Y182 and MAP2K1\n", + "looking for paths in the network with length: 4 for node MAPK14_Y182 and MAP2K1\n", + "looking for paths in the network with length: 5 for node MAPK14_Y182 and MAP2K1\n", + "looking for paths in the network with length: 6 for node MAPK14_Y182 and MAP2K1\n", + "looking for paths in the network with length: 7 for node MAPK14_Y182 and MAP2K1\n", + "looking for paths in the network with length: 8 for node MAPK14_Y182 and MAP2K1\n", + "looking for paths in the network with length: 9 for node MAPK14_Y182 and MAP2K1\n", + "looking for paths in the network with length: 10 for node MAPK14_Y182 and MAP2K1\n", + "i_search = 4\n", + "Looking for paths with length: 0 for node MAPK14_Y182 and MAP2K1\n", + "i_search = 4\n", + "Looking for paths with length: 1 for node MAPK14_Y182 and MAP2K1\n", + "i_search = 4\n", + "Looking for paths with length: 2 for node MAPK14_Y182 and MAP2K1\n", + "i_search = 4\n", + "Looking for paths with length: 3 for node MAPK14_Y182 and MAP2K1\n", + "i_search = 4\n", + "Looking for paths with length: 4 for node MAPK14_Y182 and MAP2K1\n", + "looking for paths in the network with length: 0 for node MAPK14_Y182 and RPS6KA1\n", + "looking for paths in the network with length: 1 for node MAPK14_Y182 and RPS6KA1\n", + "looking for paths in the network with length: 2 for node MAPK14_Y182 and RPS6KA1\n", + "looking for paths in the network with length: 3 for node MAPK14_Y182 and RPS6KA1\n", + "looking for paths in the network with length: 4 for node MAPK14_Y182 and RPS6KA1\n", + "looking for paths in the network with length: 5 for node MAPK14_Y182 and RPS6KA1\n", + "looking for paths in the network with length: 6 for node MAPK14_Y182 and RPS6KA1\n", + "looking for paths in the network with length: 7 for node MAPK14_Y182 and RPS6KA1\n", + "looking for paths in the network with length: 8 for node MAPK14_Y182 and RPS6KA1\n", + "looking for paths in the network with length: 9 for node MAPK14_Y182 and RPS6KA1\n", + "looking for paths in the network with length: 10 for node MAPK14_Y182 and RPS6KA1\n", + "i_search = 4\n", + "Looking for paths with length: 0 for node MAPK14_Y182 and RPS6KA1\n", + "i_search = 4\n", + "Looking for paths with length: 1 for node MAPK14_Y182 and RPS6KA1\n", + "i_search = 4\n", + "Looking for paths with length: 2 for node MAPK14_Y182 and RPS6KA1\n", + "i_search = 4\n", + "Looking for paths with length: 3 for node MAPK14_Y182 and RPS6KA1\n", + "i_search = 4\n", + "Looking for paths with length: 4 for node MAPK14_Y182 and RPS6KA1\n", + "looking for paths in the network with length: 0 for node MAPK14_Y182 and CREB1\n", + "looking for paths in the network with length: 1 for node MAPK14_Y182 and CREB1\n", + "looking for paths in the network with length: 2 for node MAPK14_Y182 and CREB1\n", + "looking for paths in the network with length: 3 for node MAPK14_Y182 and CREB1\n", + "looking for paths in the network with length: 4 for node MAPK14_Y182 and CREB1\n", + "looking for paths in the network with length: 5 for node MAPK14_Y182 and CREB1\n", + "looking for paths in the network with length: 6 for node MAPK14_Y182 and CREB1\n", + "looking for paths in the network with length: 7 for node MAPK14_Y182 and CREB1\n", + "looking for paths in the network with length: 8 for node MAPK14_Y182 and CREB1\n", + "looking for paths in the network with length: 9 for node MAPK14_Y182 and CREB1\n", + "looking for paths in the network with length: 10 for node MAPK14_Y182 and CREB1\n", + "i_search = 4\n", + "Looking for paths with length: 0 for node MAPK14_Y182 and CREB1\n", + "i_search = 4\n", + "Looking for paths with length: 1 for node MAPK14_Y182 and CREB1\n", + "i_search = 4\n", + "Looking for paths with length: 2 for node MAPK14_Y182 and CREB1\n", + "i_search = 4\n", + "Looking for paths with length: 3 for node MAPK14_Y182 and CREB1\n", + "i_search = 4\n", + "Looking for paths with length: 4 for node MAPK14_Y182 and CREB1\n", + "looking for paths in the network with length: 0 for node MAPK14_Y182 and NFKBIA\n", + "looking for paths in the network with length: 1 for node MAPK14_Y182 and NFKBIA\n", + "looking for paths in the network with length: 2 for node MAPK14_Y182 and NFKBIA\n", + "looking for paths in the network with length: 3 for node MAPK14_Y182 and NFKBIA\n", + "looking for paths in the network with length: 4 for node MAPK14_Y182 and NFKBIA\n", + "looking for paths in the network with length: 5 for node MAPK14_Y182 and NFKBIA\n", + "looking for paths in the network with length: 6 for node MAPK14_Y182 and NFKBIA\n", + "looking for paths in the network with length: 7 for node MAPK14_Y182 and NFKBIA\n", + "looking for paths in the network with length: 8 for node MAPK14_Y182 and NFKBIA\n", + "looking for paths in the network with length: 9 for node MAPK14_Y182 and NFKBIA\n", + "looking for paths in the network with length: 10 for node MAPK14_Y182 and NFKBIA\n", + "i_search = 4\n", + "Looking for paths with length: 0 for node MAPK14_Y182 and NFKBIA\n", + "i_search = 4\n", + "Looking for paths with length: 1 for node MAPK14_Y182 and NFKBIA\n", + "i_search = 4\n", + "Looking for paths with length: 2 for node MAPK14_Y182 and NFKBIA\n", + "i_search = 4\n", + "Looking for paths with length: 3 for node MAPK14_Y182 and NFKBIA\n", + "i_search = 4\n", + "Looking for paths with length: 4 for node MAPK14_Y182 and NFKBIA\n", + "looking for paths in the network with length: 0 for node MAPK14_Y182 and MTOR\n", + "looking for paths in the network with length: 1 for node MAPK14_Y182 and MTOR\n", + "looking for paths in the network with length: 2 for node MAPK14_Y182 and MTOR\n", + "looking for paths in the network with length: 3 for node MAPK14_Y182 and MTOR\n", + "looking for paths in the network with length: 4 for node MAPK14_Y182 and MTOR\n", + "looking for paths in the network with length: 5 for node MAPK14_Y182 and MTOR\n", + "looking for paths in the network with length: 6 for node MAPK14_Y182 and MTOR\n", + "looking for paths in the network with length: 7 for node MAPK14_Y182 and MTOR\n", + "looking for paths in the network with length: 8 for node MAPK14_Y182 and MTOR\n", + "looking for paths in the network with length: 9 for node MAPK14_Y182 and MTOR\n", + "looking for paths in the network with length: 10 for node MAPK14_Y182 and MTOR\n", + "i_search = 4\n", + "Looking for paths with length: 0 for node MAPK14_Y182 and MTOR\n", + "i_search = 4\n", + "Looking for paths with length: 1 for node MAPK14_Y182 and MTOR\n", + "i_search = 4\n", + "Looking for paths with length: 2 for node MAPK14_Y182 and MTOR\n", + "i_search = 4\n", + "Looking for paths with length: 3 for node MAPK14_Y182 and MTOR\n", + "i_search = 4\n", + "Looking for paths with length: 4 for node MAPK14_Y182 and MTOR\n", + "looking for paths in the network with length: 0 for node MAPK14_Y182 and JUN\n", + "looking for paths in the network with length: 1 for node MAPK14_Y182 and JUN\n", + "looking for paths in the network with length: 2 for node MAPK14_Y182 and JUN\n", + "looking for paths in the network with length: 3 for node MAPK14_Y182 and JUN\n", + "looking for paths in the network with length: 4 for node MAPK14_Y182 and JUN\n", + "looking for paths in the network with length: 5 for node MAPK14_Y182 and JUN\n", + "looking for paths in the network with length: 6 for node MAPK14_Y182 and JUN\n", + "looking for paths in the network with length: 7 for node MAPK14_Y182 and JUN\n", + "looking for paths in the network with length: 8 for node MAPK14_Y182 and JUN\n", + "looking for paths in the network with length: 9 for node MAPK14_Y182 and JUN\n", + "looking for paths in the network with length: 10 for node MAPK14_Y182 and JUN\n", + "i_search = 4\n", + "Looking for paths with length: 0 for node MAPK14_Y182 and JUN\n", + "i_search = 4\n", + "Looking for paths with length: 1 for node MAPK14_Y182 and JUN\n", + "i_search = 4\n", + "Looking for paths with length: 2 for node MAPK14_Y182 and JUN\n", + "i_search = 4\n", + "Looking for paths with length: 3 for node MAPK14_Y182 and JUN\n", + "i_search = 4\n", + "Looking for paths with length: 4 for node MAPK14_Y182 and JUN\n", + "looking for paths in the network with length: 0 for node MAPK14_Y182 and EGFR\n", + "looking for paths in the network with length: 1 for node MAPK14_Y182 and EGFR\n", + "looking for paths in the network with length: 2 for node MAPK14_Y182 and EGFR\n", + "looking for paths in the network with length: 3 for node MAPK14_Y182 and EGFR\n", + "looking for paths in the network with length: 4 for node MAPK14_Y182 and EGFR\n", + "looking for paths in the network with length: 5 for node MAPK14_Y182 and EGFR\n", + "looking for paths in the network with length: 6 for node MAPK14_Y182 and EGFR\n", + "looking for paths in the network with length: 7 for node MAPK14_Y182 and EGFR\n", + "looking for paths in the network with length: 8 for node MAPK14_Y182 and EGFR\n", + "looking for paths in the network with length: 9 for node MAPK14_Y182 and EGFR\n", + "looking for paths in the network with length: 10 for node MAPK14_Y182 and EGFR\n", + "i_search = 4\n", + "Looking for paths with length: 0 for node MAPK14_Y182 and EGFR\n", + "i_search = 4\n", + "Looking for paths with length: 1 for node MAPK14_Y182 and EGFR\n", + "i_search = 4\n", + "Looking for paths with length: 2 for node MAPK14_Y182 and EGFR\n", + "i_search = 4\n", + "Looking for paths with length: 3 for node MAPK14_Y182 and EGFR\n", + "i_search = 4\n", + "Looking for paths with length: 4 for node MAPK14_Y182 and EGFR\n", + "looking for paths in the network with length: 0 for node MAPK14_Y182 and MAPK3\n", + "looking for paths in the network with length: 1 for node MAPK14_Y182 and MAPK3\n", + "looking for paths in the network with length: 2 for node MAPK14_Y182 and MAPK3\n", + "looking for paths in the network with length: 3 for node MAPK14_Y182 and MAPK3\n", + "looking for paths in the network with length: 4 for node MAPK14_Y182 and MAPK3\n", + "looking for paths in the network with length: 5 for node MAPK14_Y182 and MAPK3\n", + "looking for paths in the network with length: 6 for node MAPK14_Y182 and MAPK3\n", + "looking for paths in the network with length: 7 for node MAPK14_Y182 and MAPK3\n", + "looking for paths in the network with length: 8 for node MAPK14_Y182 and MAPK3\n", + "looking for paths in the network with length: 9 for node MAPK14_Y182 and MAPK3\n", + "looking for paths in the network with length: 10 for node MAPK14_Y182 and MAPK3\n", + "i_search = 4\n", + "Looking for paths with length: 0 for node MAPK14_Y182 and MAPK3\n", + "i_search = 4\n", + "Looking for paths with length: 1 for node MAPK14_Y182 and MAPK3\n", + "i_search = 4\n", + "Looking for paths with length: 2 for node MAPK14_Y182 and MAPK3\n", + "i_search = 4\n", + "Looking for paths with length: 3 for node MAPK14_Y182 and MAPK3\n", + "i_search = 4\n", + "Looking for paths with length: 4 for node MAPK14_Y182 and MAPK3\n", + "looking for paths in the network with length: 0 for node MAPK14_Y182 and PTPN11\n", + "looking for paths in the network with length: 1 for node MAPK14_Y182 and PTPN11\n", + "looking for paths in the network with length: 2 for node MAPK14_Y182 and PTPN11\n", + "looking for paths in the network with length: 3 for node MAPK14_Y182 and PTPN11\n", + "looking for paths in the network with length: 4 for node MAPK14_Y182 and PTPN11\n", + "looking for paths in the network with length: 5 for node MAPK14_Y182 and PTPN11\n", + "looking for paths in the network with length: 6 for node MAPK14_Y182 and PTPN11\n", + "looking for paths in the network with length: 7 for node MAPK14_Y182 and PTPN11\n", + "looking for paths in the network with length: 8 for node MAPK14_Y182 and PTPN11\n", + "looking for paths in the network with length: 9 for node MAPK14_Y182 and PTPN11\n", + "looking for paths in the network with length: 10 for node MAPK14_Y182 and PTPN11\n", + "i_search = 4\n", + "Looking for paths with length: 0 for node MAPK14_Y182 and PTPN11\n", + "i_search = 4\n", + "Looking for paths with length: 1 for node MAPK14_Y182 and PTPN11\n", + "i_search = 4\n", + "Looking for paths with length: 2 for node MAPK14_Y182 and PTPN11\n", + "i_search = 4\n", + "Looking for paths with length: 3 for node MAPK14_Y182 and PTPN11\n", + "i_search = 4\n", + "Looking for paths with length: 4 for node MAPK14_Y182 and PTPN11\n", + "looking for paths in the network with length: 0 for node MAPK14_Y182 and STAT3\n", + "looking for paths in the network with length: 1 for node MAPK14_Y182 and STAT3\n", + "looking for paths in the network with length: 2 for node MAPK14_Y182 and STAT3\n", + "looking for paths in the network with length: 3 for node MAPK14_Y182 and STAT3\n", + "looking for paths in the network with length: 4 for node MAPK14_Y182 and STAT3\n", + "looking for paths in the network with length: 5 for node MAPK14_Y182 and STAT3\n", + "looking for paths in the network with length: 6 for node MAPK14_Y182 and STAT3\n", + "looking for paths in the network with length: 7 for node MAPK14_Y182 and STAT3\n", + "looking for paths in the network with length: 8 for node MAPK14_Y182 and STAT3\n", + "looking for paths in the network with length: 9 for node MAPK14_Y182 and STAT3\n", + "looking for paths in the network with length: 10 for node MAPK14_Y182 and STAT3\n", + "i_search = 4\n", + "Looking for paths with length: 0 for node MAPK14_Y182 and STAT3\n", + "i_search = 4\n", + "Looking for paths with length: 1 for node MAPK14_Y182 and STAT3\n", + "i_search = 4\n", + "Looking for paths with length: 2 for node MAPK14_Y182 and STAT3\n", + "i_search = 4\n", + "Looking for paths with length: 3 for node MAPK14_Y182 and STAT3\n", + "i_search = 4\n", + "Looking for paths with length: 4 for node MAPK14_Y182 and STAT3\n", + "looking for paths in the network with length: 0 for node MAPK14_Y182 and CHEK2\n", + "looking for paths in the network with length: 1 for node MAPK14_Y182 and CHEK2\n", + "looking for paths in the network with length: 2 for node MAPK14_Y182 and CHEK2\n", + "looking for paths in the network with length: 3 for node MAPK14_Y182 and CHEK2\n", + "looking for paths in the network with length: 4 for node MAPK14_Y182 and CHEK2\n", + "looking for paths in the network with length: 5 for node MAPK14_Y182 and CHEK2\n", + "looking for paths in the network with length: 6 for node MAPK14_Y182 and CHEK2\n", + "looking for paths in the network with length: 7 for node MAPK14_Y182 and CHEK2\n", + "looking for paths in the network with length: 8 for node MAPK14_Y182 and CHEK2\n", + "looking for paths in the network with length: 9 for node MAPK14_Y182 and CHEK2\n", + "looking for paths in the network with length: 10 for node MAPK14_Y182 and CHEK2\n", + "i_search = 4\n", + "Looking for paths with length: 0 for node MAPK14_Y182 and CHEK2\n", + "i_search = 4\n", + "Looking for paths with length: 1 for node MAPK14_Y182 and CHEK2\n", + "i_search = 4\n", + "Looking for paths with length: 2 for node MAPK14_Y182 and CHEK2\n", + "i_search = 4\n", + "Looking for paths with length: 3 for node MAPK14_Y182 and CHEK2\n", + "i_search = 4\n", + "Looking for paths with length: 4 for node MAPK14_Y182 and CHEK2\n", + "looking for paths in the network with length: 0 for node MAPK14_Y182 and RELA\n", + "looking for paths in the network with length: 1 for node MAPK14_Y182 and RELA\n", + "looking for paths in the network with length: 2 for node MAPK14_Y182 and RELA\n", + "looking for paths in the network with length: 3 for node MAPK14_Y182 and RELA\n", + "looking for paths in the network with length: 4 for node MAPK14_Y182 and RELA\n", + "looking for paths in the network with length: 5 for node MAPK14_Y182 and RELA\n", + "looking for paths in the network with length: 6 for node MAPK14_Y182 and RELA\n", + "looking for paths in the network with length: 7 for node MAPK14_Y182 and RELA\n", + "looking for paths in the network with length: 8 for node MAPK14_Y182 and RELA\n", + "looking for paths in the network with length: 9 for node MAPK14_Y182 and RELA\n", + "looking for paths in the network with length: 10 for node MAPK14_Y182 and RELA\n", + "i_search = 4\n", + "Looking for paths with length: 0 for node MAPK14_Y182 and RELA\n", + "i_search = 4\n", + "Looking for paths with length: 1 for node MAPK14_Y182 and RELA\n", + "i_search = 4\n", + "Looking for paths with length: 2 for node MAPK14_Y182 and RELA\n", + "i_search = 4\n", + "Looking for paths with length: 3 for node MAPK14_Y182 and RELA\n", + "i_search = 4\n", + "Looking for paths with length: 4 for node MAPK14_Y182 and RELA\n", + "looking for paths in the network with length: 0 for node MAPK14_Y182 and MARCKS\n", + "looking for paths in the network with length: 1 for node MAPK14_Y182 and MARCKS\n", + "looking for paths in the network with length: 2 for node MAPK14_Y182 and MARCKS\n", + "looking for paths in the network with length: 3 for node MAPK14_Y182 and MARCKS\n", + "looking for paths in the network with length: 4 for node MAPK14_Y182 and MARCKS\n", + "looking for paths in the network with length: 5 for node MAPK14_Y182 and MARCKS\n", + "looking for paths in the network with length: 6 for node MAPK14_Y182 and MARCKS\n", + "looking for paths in the network with length: 7 for node MAPK14_Y182 and MARCKS\n", + "looking for paths in the network with length: 8 for node MAPK14_Y182 and MARCKS\n", + "looking for paths in the network with length: 9 for node MAPK14_Y182 and MARCKS\n", + "looking for paths in the network with length: 10 for node MAPK14_Y182 and MARCKS\n", + "i_search = 4\n", + "Looking for paths with length: 0 for node MAPK14_Y182 and MARCKS\n", + "i_search = 4\n", + "Looking for paths with length: 1 for node MAPK14_Y182 and MARCKS\n", + "i_search = 4\n", + "Looking for paths with length: 2 for node MAPK14_Y182 and MARCKS\n", + "i_search = 4\n", + "Looking for paths with length: 3 for node MAPK14_Y182 and MARCKS\n", + "i_search = 4\n", + "Looking for paths with length: 4 for node MAPK14_Y182 and MARCKS\n", + "looking for paths in the network with length: 0 for node MAP2K1_S218 and MAP2K1_S222\n", + "looking for paths in the network with length: 1 for node MAP2K1_S218 and MAP2K1_S222\n", + "looking for paths in the network with length: 2 for node MAP2K1_S218 and MAP2K1_S222\n", + "looking for paths in the network with length: 3 for node MAP2K1_S218 and MAP2K1_S222\n", + "looking for paths in the network with length: 4 for node MAP2K1_S218 and MAP2K1_S222\n", + "looking for paths in the network with length: 5 for node MAP2K1_S218 and MAP2K1_S222\n", + "looking for paths in the network with length: 6 for node MAP2K1_S218 and MAP2K1_S222\n", + "looking for paths in the network with length: 7 for node MAP2K1_S218 and MAP2K1_S222\n", + "looking for paths in the network with length: 8 for node MAP2K1_S218 and MAP2K1_S222\n", + "looking for paths in the network with length: 9 for node MAP2K1_S218 and MAP2K1_S222\n", + "looking for paths in the network with length: 10 for node MAP2K1_S218 and MAP2K1_S222\n", + "i_search = 4\n", + "Looking for paths with length: 0 for node MAP2K1_S218 and MAP2K1_S222\n", + "i_search = 4\n", + "Looking for paths with length: 1 for node MAP2K1_S218 and MAP2K1_S222\n", + "i_search = 4\n", + "Looking for paths with length: 2 for node MAP2K1_S218 and MAP2K1_S222\n", + "i_search = 4\n", + "Looking for paths with length: 3 for node MAP2K1_S218 and MAP2K1_S222\n", + "i_search = 4\n", + "Looking for paths with length: 4 for node MAP2K1_S218 and MAP2K1_S222\n", + "[['MAP2K1_S218', 'MAP2K1', 'RAF1_S338', 'RAF1', 'MAP2K1_S222'], ['MAP2K1_S218', 'RAF1', 'RAF1_S338', 'MAP2K1', 'MAP2K1_S222']]\n", + "MAP2K1_S218 MAP2K1\n", + "MAP2K1 RAF1_S338\n", + "RAF1_S338 RAF1\n", + "RAF1 MAP2K1_S222\n", + "RAF1 MAP2K1_S218\n", + "RAF1 RAF1_S338\n", + "MAP2K1 RAF1_S338\n", + "MAP2K1_S222 MAP2K1\n", + "looking for paths in the network with length: 0 for node MAP2K1_S218 and RPS6KA1_S380\n", + "looking for paths in the network with length: 1 for node MAP2K1_S218 and RPS6KA1_S380\n", + "looking for paths in the network with length: 2 for node MAP2K1_S218 and RPS6KA1_S380\n", + "looking for paths in the network with length: 3 for node MAP2K1_S218 and RPS6KA1_S380\n", + "looking for paths in the network with length: 4 for node MAP2K1_S218 and RPS6KA1_S380\n", + "Found a path!\n", + "[['MAP2K1_S218', 'MAP2K1', 'MAPK3_T202', 'MAPK3', 'RPS6KA1_S380']]\n", + "looking for paths in the network with length: 0 for node MAP2K1_S218 and CREB1_S133\n", + "looking for paths in the network with length: 1 for node MAP2K1_S218 and CREB1_S133\n", + "looking for paths in the network with length: 2 for node MAP2K1_S218 and CREB1_S133\n", + "looking for paths in the network with length: 3 for node MAP2K1_S218 and CREB1_S133\n", + "looking for paths in the network with length: 4 for node MAP2K1_S218 and CREB1_S133\n", + "looking for paths in the network with length: 5 for node MAP2K1_S218 and CREB1_S133\n", + "looking for paths in the network with length: 6 for node MAP2K1_S218 and CREB1_S133\n", + "looking for paths in the network with length: 7 for node MAP2K1_S218 and CREB1_S133\n", + "looking for paths in the network with length: 8 for node MAP2K1_S218 and CREB1_S133\n", + "looking for paths in the network with length: 9 for node MAP2K1_S218 and CREB1_S133\n", + "looking for paths in the network with length: 10 for node MAP2K1_S218 and CREB1_S133\n", + "i_search = 4\n", + "Looking for paths with length: 0 for node MAP2K1_S218 and CREB1_S133\n", + "i_search = 4\n", + "Looking for paths with length: 1 for node MAP2K1_S218 and CREB1_S133\n", + "i_search = 4\n", + "Looking for paths with length: 2 for node MAP2K1_S218 and CREB1_S133\n", + "i_search = 4\n", + "Looking for paths with length: 3 for node MAP2K1_S218 and CREB1_S133\n", + "i_search = 4\n", + "Looking for paths with length: 4 for node MAP2K1_S218 and CREB1_S133\n", + "looking for paths in the network with length: 0 for node MAP2K1_S218 and NFKBIA_S32\n", + "looking for paths in the network with length: 1 for node MAP2K1_S218 and NFKBIA_S32\n", + "looking for paths in the network with length: 2 for node MAP2K1_S218 and NFKBIA_S32\n", + "looking for paths in the network with length: 3 for node MAP2K1_S218 and NFKBIA_S32\n", + "looking for paths in the network with length: 4 for node MAP2K1_S218 and NFKBIA_S32\n", + "looking for paths in the network with length: 5 for node MAP2K1_S218 and NFKBIA_S32\n", + "looking for paths in the network with length: 6 for node MAP2K1_S218 and NFKBIA_S32\n", + "looking for paths in the network with length: 7 for node MAP2K1_S218 and NFKBIA_S32\n", + "looking for paths in the network with length: 8 for node MAP2K1_S218 and NFKBIA_S32\n", + "looking for paths in the network with length: 9 for node MAP2K1_S218 and NFKBIA_S32\n", + "looking for paths in the network with length: 10 for node MAP2K1_S218 and NFKBIA_S32\n", + "i_search = 4\n", + "Looking for paths with length: 0 for node MAP2K1_S218 and NFKBIA_S32\n", + "i_search = 4\n", + "Looking for paths with length: 1 for node MAP2K1_S218 and NFKBIA_S32\n", + "i_search = 4\n", + "Looking for paths with length: 2 for node MAP2K1_S218 and NFKBIA_S32\n", + "i_search = 4\n", + "Looking for paths with length: 3 for node MAP2K1_S218 and NFKBIA_S32\n", + "i_search = 4\n", + "Looking for paths with length: 4 for node MAP2K1_S218 and NFKBIA_S32\n", + "looking for paths in the network with length: 0 for node MAP2K1_S218 and NFKBIA_S36\n", + "looking for paths in the network with length: 1 for node MAP2K1_S218 and NFKBIA_S36\n", + "looking for paths in the network with length: 2 for node MAP2K1_S218 and NFKBIA_S36\n", + "looking for paths in the network with length: 3 for node MAP2K1_S218 and NFKBIA_S36\n", + "looking for paths in the network with length: 4 for node MAP2K1_S218 and NFKBIA_S36\n", + "looking for paths in the network with length: 5 for node MAP2K1_S218 and NFKBIA_S36\n", + "looking for paths in the network with length: 6 for node MAP2K1_S218 and NFKBIA_S36\n", + "looking for paths in the network with length: 7 for node MAP2K1_S218 and NFKBIA_S36\n", + "looking for paths in the network with length: 8 for node MAP2K1_S218 and NFKBIA_S36\n", + "looking for paths in the network with length: 9 for node MAP2K1_S218 and NFKBIA_S36\n", + "looking for paths in the network with length: 10 for node MAP2K1_S218 and NFKBIA_S36\n", + "i_search = 4\n", + "Looking for paths with length: 0 for node MAP2K1_S218 and NFKBIA_S36\n", + "i_search = 4\n", + "Looking for paths with length: 1 for node MAP2K1_S218 and NFKBIA_S36\n", + "i_search = 4\n", + "Looking for paths with length: 2 for node MAP2K1_S218 and NFKBIA_S36\n", + "i_search = 4\n", + "Looking for paths with length: 3 for node MAP2K1_S218 and NFKBIA_S36\n", + "i_search = 4\n", + "Looking for paths with length: 4 for node MAP2K1_S218 and NFKBIA_S36\n", + "looking for paths in the network with length: 0 for node MAP2K1_S218 and MTOR_S2448\n", + "looking for paths in the network with length: 1 for node MAP2K1_S218 and MTOR_S2448\n", + "looking for paths in the network with length: 2 for node MAP2K1_S218 and MTOR_S2448\n", + "looking for paths in the network with length: 3 for node MAP2K1_S218 and MTOR_S2448\n", + "looking for paths in the network with length: 4 for node MAP2K1_S218 and MTOR_S2448\n", + "looking for paths in the network with length: 5 for node MAP2K1_S218 and MTOR_S2448\n", + "looking for paths in the network with length: 6 for node MAP2K1_S218 and MTOR_S2448\n", + "looking for paths in the network with length: 7 for node MAP2K1_S218 and MTOR_S2448\n", + "looking for paths in the network with length: 8 for node MAP2K1_S218 and MTOR_S2448\n", + "looking for paths in the network with length: 9 for node MAP2K1_S218 and MTOR_S2448\n", + "looking for paths in the network with length: 10 for node MAP2K1_S218 and MTOR_S2448\n", + "i_search = 4\n", + "Looking for paths with length: 0 for node MAP2K1_S218 and MTOR_S2448\n", + "i_search = 4\n", + "Looking for paths with length: 1 for node MAP2K1_S218 and MTOR_S2448\n", + "i_search = 4\n", + "Looking for paths with length: 2 for node MAP2K1_S218 and MTOR_S2448\n", + "i_search = 4\n", + "Looking for paths with length: 3 for node MAP2K1_S218 and MTOR_S2448\n", + "i_search = 4\n", + "Looking for paths with length: 4 for node MAP2K1_S218 and MTOR_S2448\n", + "looking for paths in the network with length: 0 for node MAP2K1_S218 and JUN_S63\n", + "looking for paths in the network with length: 1 for node MAP2K1_S218 and JUN_S63\n", + "looking for paths in the network with length: 2 for node MAP2K1_S218 and JUN_S63\n", + "looking for paths in the network with length: 3 for node MAP2K1_S218 and JUN_S63\n", + "looking for paths in the network with length: 4 for node MAP2K1_S218 and JUN_S63\n", + "looking for paths in the network with length: 5 for node MAP2K1_S218 and JUN_S63\n", + "looking for paths in the network with length: 6 for node MAP2K1_S218 and JUN_S63\n", + "looking for paths in the network with length: 7 for node MAP2K1_S218 and JUN_S63\n", + "looking for paths in the network with length: 8 for node MAP2K1_S218 and JUN_S63\n", + "looking for paths in the network with length: 9 for node MAP2K1_S218 and JUN_S63\n", + "looking for paths in the network with length: 10 for node MAP2K1_S218 and JUN_S63\n", + "i_search = 4\n", + "Looking for paths with length: 0 for node MAP2K1_S218 and JUN_S63\n", + "i_search = 4\n", + "Looking for paths with length: 1 for node MAP2K1_S218 and JUN_S63\n", + "i_search = 4\n", + "Looking for paths with length: 2 for node MAP2K1_S218 and JUN_S63\n", + "i_search = 4\n", + "Looking for paths with length: 3 for node MAP2K1_S218 and JUN_S63\n", + "i_search = 4\n", + "Looking for paths with length: 4 for node MAP2K1_S218 and JUN_S63\n", + "[['MAP2K1_S218', 'MAP2K1', 'MAPK3_T207', 'MAPK3', 'JUN_S63'], ['MAP2K1_S218', 'MAP2K1', 'MAPK1_Y187', 'MAPK1', 'JUN_S63'], ['MAP2K1_S218', 'MAP2K1', 'MAPK1_T185', 'MAPK1', 'JUN_S63'], ['MAP2K1_S218', 'MAP2K1', 'MAPK3_Y204', 'MAPK3', 'JUN_S63'], ['MAP2K1_S218', 'MAP2K1', 'MAPK3_T202', 'MAPK3', 'JUN_S63']]\n", + "MAP2K1_S218 MAP2K1\n", + "MAP2K1 MAPK3_T207\n", + "MAPK3_T207 MAPK3\n", + "MAPK3 JUN_S63\n", + "MAP2K1_S218 MAP2K1\n", + "MAP2K1 MAPK1_Y187\n", + "MAPK1_Y187 MAPK1\n", + "MAPK1 JUN_S63\n", + "MAP2K1_S218 MAP2K1\n", + "MAP2K1 MAPK1_T185\n", + "MAPK1_T185 MAPK1\n", + "MAPK1 JUN_S63\n", + "MAP2K1_S218 MAP2K1\n", + "MAP2K1 MAPK3_Y204\n", + "MAPK3_Y204 MAPK3\n", + "MAPK3 JUN_S63\n", + "MAP2K1_S218 MAP2K1\n", + "MAP2K1 MAPK3_T202\n", + "MAPK3_T202 MAPK3\n", + "MAPK3 JUN_S63\n", + "looking for paths in the network with length: 0 for node MAP2K1_S218 and EGFR_Y1068\n", + "looking for paths in the network with length: 1 for node MAP2K1_S218 and EGFR_Y1068\n", + "looking for paths in the network with length: 2 for node MAP2K1_S218 and EGFR_Y1068\n", + "looking for paths in the network with length: 3 for node MAP2K1_S218 and EGFR_Y1068\n", + "looking for paths in the network with length: 4 for node MAP2K1_S218 and EGFR_Y1068\n", + "looking for paths in the network with length: 5 for node MAP2K1_S218 and EGFR_Y1068\n", + "looking for paths in the network with length: 6 for node MAP2K1_S218 and EGFR_Y1068\n", + "looking for paths in the network with length: 7 for node MAP2K1_S218 and EGFR_Y1068\n", + "looking for paths in the network with length: 8 for node MAP2K1_S218 and EGFR_Y1068\n", + "looking for paths in the network with length: 9 for node MAP2K1_S218 and EGFR_Y1068\n", + "looking for paths in the network with length: 10 for node MAP2K1_S218 and EGFR_Y1068\n", + "i_search = 4\n", + "Looking for paths with length: 0 for node MAP2K1_S218 and EGFR_Y1068\n", + "i_search = 4\n", + "Looking for paths with length: 1 for node MAP2K1_S218 and EGFR_Y1068\n", + "i_search = 4\n", + "Looking for paths with length: 2 for node MAP2K1_S218 and EGFR_Y1068\n", + "i_search = 4\n", + "Looking for paths with length: 3 for node MAP2K1_S218 and EGFR_Y1068\n", + "i_search = 4\n", + "Looking for paths with length: 4 for node MAP2K1_S218 and EGFR_Y1068\n", + "looking for paths in the network with length: 0 for node MAP2K1_S218 and MAPK3_T202\n", + "looking for paths in the network with length: 1 for node MAP2K1_S218 and MAPK3_T202\n", + "looking for paths in the network with length: 2 for node MAP2K1_S218 and MAPK3_T202\n", + "Found a path!\n", + "[['MAP2K1_S218', 'MAP2K1', 'MAPK3_T202']]\n", + "looking for paths in the network with length: 0 for node MAP2K1_S218 and MAPK3_Y204\n", + "looking for paths in the network with length: 1 for node MAP2K1_S218 and MAPK3_Y204\n", + "looking for paths in the network with length: 2 for node MAP2K1_S218 and MAPK3_Y204\n", + "Found a path!\n", + "[['MAP2K1_S218', 'MAP2K1', 'MAPK3_Y204']]\n", + "looking for paths in the network with length: 0 for node MAP2K1_S218 and PTPN11_Y542\n", + "looking for paths in the network with length: 1 for node MAP2K1_S218 and PTPN11_Y542\n", + "looking for paths in the network with length: 2 for node MAP2K1_S218 and PTPN11_Y542\n", + "looking for paths in the network with length: 3 for node MAP2K1_S218 and PTPN11_Y542\n", + "looking for paths in the network with length: 4 for node MAP2K1_S218 and PTPN11_Y542\n", + "looking for paths in the network with length: 5 for node MAP2K1_S218 and PTPN11_Y542\n", + "looking for paths in the network with length: 6 for node MAP2K1_S218 and PTPN11_Y542\n", + "looking for paths in the network with length: 7 for node MAP2K1_S218 and PTPN11_Y542\n", + "looking for paths in the network with length: 8 for node MAP2K1_S218 and PTPN11_Y542\n", + "looking for paths in the network with length: 9 for node MAP2K1_S218 and PTPN11_Y542\n", + "looking for paths in the network with length: 10 for node MAP2K1_S218 and PTPN11_Y542\n", + "i_search = 4\n", + "Looking for paths with length: 0 for node MAP2K1_S218 and PTPN11_Y542\n", + "i_search = 4\n", + "Looking for paths with length: 1 for node MAP2K1_S218 and PTPN11_Y542\n", + "i_search = 4\n", + "Looking for paths with length: 2 for node MAP2K1_S218 and PTPN11_Y542\n", + "i_search = 4\n", + "Looking for paths with length: 3 for node MAP2K1_S218 and PTPN11_Y542\n", + "i_search = 4\n", + "Looking for paths with length: 4 for node MAP2K1_S218 and PTPN11_Y542\n", + "looking for paths in the network with length: 0 for node MAP2K1_S218 and STAT3_Y705\n", + "looking for paths in the network with length: 1 for node MAP2K1_S218 and STAT3_Y705\n", + "looking for paths in the network with length: 2 for node MAP2K1_S218 and STAT3_Y705\n", + "looking for paths in the network with length: 3 for node MAP2K1_S218 and STAT3_Y705\n", + "looking for paths in the network with length: 4 for node MAP2K1_S218 and STAT3_Y705\n", + "looking for paths in the network with length: 5 for node MAP2K1_S218 and STAT3_Y705\n", + "looking for paths in the network with length: 6 for node MAP2K1_S218 and STAT3_Y705\n", + "looking for paths in the network with length: 7 for node MAP2K1_S218 and STAT3_Y705\n", + "looking for paths in the network with length: 8 for node MAP2K1_S218 and STAT3_Y705\n", + "Found a path!\n", + "[['MAP2K1_S218', 'MAP2K1', 'MAPK3_Y204', 'MAPK3', 'GSK3B_T43', 'GSK3B', 'SRC_S493', 'SRC', 'STAT3_Y705'], ['MAP2K1_S218', 'MAP2K1', 'MAPK3_Y204', 'MAPK3', 'GSK3B_T43', 'GSK3B', 'SRC_S51', 'SRC', 'STAT3_Y705'], ['MAP2K1_S218', 'MAP2K1', 'MAPK3_Y204', 'MAPK3', 'GSK3B_T43', 'GSK3B', 'SRC_S43', 'SRC', 'STAT3_Y705'], ['MAP2K1_S218', 'MAP2K1', 'MAPK3_Y204', 'MAPK3', 'GSK3B_T43', 'GSK3B', 'SRC_Y419', 'SRC', 'STAT3_Y705'], ['MAP2K1_S218', 'MAP2K1', 'MAPK3_T202', 'MAPK3', 'GSK3B_T43', 'GSK3B', 'SRC_S493', 'SRC', 'STAT3_Y705'], ['MAP2K1_S218', 'MAP2K1', 'MAPK3_T202', 'MAPK3', 'GSK3B_T43', 'GSK3B', 'SRC_S51', 'SRC', 'STAT3_Y705'], ['MAP2K1_S218', 'MAP2K1', 'MAPK3_T202', 'MAPK3', 'GSK3B_T43', 'GSK3B', 'SRC_S43', 'SRC', 'STAT3_Y705'], ['MAP2K1_S218', 'MAP2K1', 'MAPK3_T202', 'MAPK3', 'GSK3B_T43', 'GSK3B', 'SRC_Y419', 'SRC', 'STAT3_Y705'], ['MAP2K1_S218', 'MAP2K1', 'MAPK3_T207', 'MAPK3', 'GSK3B_T43', 'GSK3B', 'SRC_S493', 'SRC', 'STAT3_Y705'], ['MAP2K1_S218', 'MAP2K1', 'MAPK3_T207', 'MAPK3', 'GSK3B_T43', 'GSK3B', 'SRC_S51', 'SRC', 'STAT3_Y705'], ['MAP2K1_S218', 'MAP2K1', 'MAPK3_T207', 'MAPK3', 'GSK3B_T43', 'GSK3B', 'SRC_S43', 'SRC', 'STAT3_Y705'], ['MAP2K1_S218', 'MAP2K1', 'MAPK3_T207', 'MAPK3', 'GSK3B_T43', 'GSK3B', 'SRC_Y419', 'SRC', 'STAT3_Y705']]\n", + "looking for paths in the network with length: 0 for node MAP2K1_S218 and CHEK2_T68\n", + "looking for paths in the network with length: 1 for node MAP2K1_S218 and CHEK2_T68\n", + "looking for paths in the network with length: 2 for node MAP2K1_S218 and CHEK2_T68\n", + "looking for paths in the network with length: 3 for node MAP2K1_S218 and CHEK2_T68\n", + "looking for paths in the network with length: 4 for node MAP2K1_S218 and CHEK2_T68\n", + "looking for paths in the network with length: 5 for node MAP2K1_S218 and CHEK2_T68\n", + "looking for paths in the network with length: 6 for node MAP2K1_S218 and CHEK2_T68\n", + "looking for paths in the network with length: 7 for node MAP2K1_S218 and CHEK2_T68\n", + "looking for paths in the network with length: 8 for node MAP2K1_S218 and CHEK2_T68\n", + "looking for paths in the network with length: 9 for node MAP2K1_S218 and CHEK2_T68\n", + "looking for paths in the network with length: 10 for node MAP2K1_S218 and CHEK2_T68\n", + "i_search = 4\n", + "Looking for paths with length: 0 for node MAP2K1_S218 and CHEK2_T68\n", + "i_search = 4\n", + "Looking for paths with length: 1 for node MAP2K1_S218 and CHEK2_T68\n", + "i_search = 4\n", + "Looking for paths with length: 2 for node MAP2K1_S218 and CHEK2_T68\n", + "i_search = 4\n", + "Looking for paths with length: 3 for node MAP2K1_S218 and CHEK2_T68\n", + "i_search = 4\n", + "Looking for paths with length: 4 for node MAP2K1_S218 and CHEK2_T68\n", + "looking for paths in the network with length: 0 for node MAP2K1_S218 and RELA_S536\n", + "looking for paths in the network with length: 1 for node MAP2K1_S218 and RELA_S536\n", + "looking for paths in the network with length: 2 for node MAP2K1_S218 and RELA_S536\n", + "looking for paths in the network with length: 3 for node MAP2K1_S218 and RELA_S536\n", + "looking for paths in the network with length: 4 for node MAP2K1_S218 and RELA_S536\n", + "looking for paths in the network with length: 5 for node MAP2K1_S218 and RELA_S536\n", + "looking for paths in the network with length: 6 for node MAP2K1_S218 and RELA_S536\n", + "looking for paths in the network with length: 7 for node MAP2K1_S218 and RELA_S536\n", + "looking for paths in the network with length: 8 for node MAP2K1_S218 and RELA_S536\n", + "Found a path!\n", + "[['MAP2K1_S218', 'MAP2K1', 'MAPK3_Y204', 'MAPK3', 'GSK3B_T43', 'GSK3B', 'TBK1_S172', 'TBK1', 'RELA_S536'], ['MAP2K1_S218', 'MAP2K1', 'MAPK3_T202', 'MAPK3', 'GSK3B_T43', 'GSK3B', 'TBK1_S172', 'TBK1', 'RELA_S536'], ['MAP2K1_S218', 'MAP2K1', 'MAPK3_T207', 'MAPK3', 'GSK3B_T43', 'GSK3B', 'TBK1_S172', 'TBK1', 'RELA_S536']]\n", + "looking for paths in the network with length: 0 for node MAP2K1_S218 and MARCKS_S170\n", + "looking for paths in the network with length: 1 for node MAP2K1_S218 and MARCKS_S170\n", + "looking for paths in the network with length: 2 for node MAP2K1_S218 and MARCKS_S170\n", + "looking for paths in the network with length: 3 for node MAP2K1_S218 and MARCKS_S170\n", + "looking for paths in the network with length: 4 for node MAP2K1_S218 and MARCKS_S170\n", + "looking for paths in the network with length: 5 for node MAP2K1_S218 and MARCKS_S170\n", + "looking for paths in the network with length: 6 for node MAP2K1_S218 and MARCKS_S170\n", + "looking for paths in the network with length: 7 for node MAP2K1_S218 and MARCKS_S170\n", + "looking for paths in the network with length: 8 for node MAP2K1_S218 and MARCKS_S170\n", + "looking for paths in the network with length: 9 for node MAP2K1_S218 and MARCKS_S170\n", + "looking for paths in the network with length: 10 for node MAP2K1_S218 and MARCKS_S170\n", + "i_search = 4\n", + "Looking for paths with length: 0 for node MAP2K1_S218 and MARCKS_S170\n", + "i_search = 4\n", + "Looking for paths with length: 1 for node MAP2K1_S218 and MARCKS_S170\n", + "i_search = 4\n", + "Looking for paths with length: 2 for node MAP2K1_S218 and MARCKS_S170\n", + "i_search = 4\n", + "Looking for paths with length: 3 for node MAP2K1_S218 and MARCKS_S170\n", + "i_search = 4\n", + "Looking for paths with length: 4 for node MAP2K1_S218 and MARCKS_S170\n", + "looking for paths in the network with length: 0 for node MAP2K1_S218 and SMAD3\n", + "looking for paths in the network with length: 1 for node MAP2K1_S218 and SMAD3\n", + "looking for paths in the network with length: 2 for node MAP2K1_S218 and SMAD3\n", + "looking for paths in the network with length: 3 for node MAP2K1_S218 and SMAD3\n", + "looking for paths in the network with length: 4 for node MAP2K1_S218 and SMAD3\n", + "looking for paths in the network with length: 5 for node MAP2K1_S218 and SMAD3\n", + "looking for paths in the network with length: 6 for node MAP2K1_S218 and SMAD3\n", + "looking for paths in the network with length: 7 for node MAP2K1_S218 and SMAD3\n", + "looking for paths in the network with length: 8 for node MAP2K1_S218 and SMAD3\n", + "looking for paths in the network with length: 9 for node MAP2K1_S218 and SMAD3\n", + "looking for paths in the network with length: 10 for node MAP2K1_S218 and SMAD3\n", + "i_search = 4\n", + "Looking for paths with length: 0 for node MAP2K1_S218 and SMAD3\n", + "i_search = 4\n", + "Looking for paths with length: 1 for node MAP2K1_S218 and SMAD3\n", + "i_search = 4\n", + "Looking for paths with length: 2 for node MAP2K1_S218 and SMAD3\n", + "i_search = 4\n", + "Looking for paths with length: 3 for node MAP2K1_S218 and SMAD3\n", + "i_search = 4\n", + "Looking for paths with length: 4 for node MAP2K1_S218 and SMAD3\n", + "looking for paths in the network with length: 0 for node MAP2K1_S218 and TP53\n", + "looking for paths in the network with length: 1 for node MAP2K1_S218 and TP53\n", + "looking for paths in the network with length: 2 for node MAP2K1_S218 and TP53\n", + "looking for paths in the network with length: 3 for node MAP2K1_S218 and TP53\n", + "looking for paths in the network with length: 4 for node MAP2K1_S218 and TP53\n", + "looking for paths in the network with length: 5 for node MAP2K1_S218 and TP53\n", + "looking for paths in the network with length: 6 for node MAP2K1_S218 and TP53\n", + "looking for paths in the network with length: 7 for node MAP2K1_S218 and TP53\n", + "looking for paths in the network with length: 8 for node MAP2K1_S218 and TP53\n", + "looking for paths in the network with length: 9 for node MAP2K1_S218 and TP53\n", + "looking for paths in the network with length: 10 for node MAP2K1_S218 and TP53\n", + "i_search = 4\n", + "Looking for paths with length: 0 for node MAP2K1_S218 and TP53\n", + "i_search = 4\n", + "Looking for paths with length: 1 for node MAP2K1_S218 and TP53\n", + "i_search = 4\n", + "Looking for paths with length: 2 for node MAP2K1_S218 and TP53\n", + "i_search = 4\n", + "Looking for paths with length: 3 for node MAP2K1_S218 and TP53\n", + "i_search = 4\n", + "Looking for paths with length: 4 for node MAP2K1_S218 and TP53\n", + "looking for paths in the network with length: 0 for node MAP2K1_S218 and AKT1S1\n", + "looking for paths in the network with length: 1 for node MAP2K1_S218 and AKT1S1\n", + "looking for paths in the network with length: 2 for node MAP2K1_S218 and AKT1S1\n", + "looking for paths in the network with length: 3 for node MAP2K1_S218 and AKT1S1\n", + "looking for paths in the network with length: 4 for node MAP2K1_S218 and AKT1S1\n", + "looking for paths in the network with length: 5 for node MAP2K1_S218 and AKT1S1\n", + "looking for paths in the network with length: 6 for node MAP2K1_S218 and AKT1S1\n", + "looking for paths in the network with length: 7 for node MAP2K1_S218 and AKT1S1\n", + "looking for paths in the network with length: 8 for node MAP2K1_S218 and AKT1S1\n", + "looking for paths in the network with length: 9 for node MAP2K1_S218 and AKT1S1\n", + "looking for paths in the network with length: 10 for node MAP2K1_S218 and AKT1S1\n", + "i_search = 4\n", + "Looking for paths with length: 0 for node MAP2K1_S218 and AKT1S1\n", + "i_search = 4\n", + "Looking for paths with length: 1 for node MAP2K1_S218 and AKT1S1\n", + "i_search = 4\n", + "Looking for paths with length: 2 for node MAP2K1_S218 and AKT1S1\n", + "i_search = 4\n", + "Looking for paths with length: 3 for node MAP2K1_S218 and AKT1S1\n", + "i_search = 4\n", + "Looking for paths with length: 4 for node MAP2K1_S218 and AKT1S1\n", + "looking for paths in the network with length: 0 for node MAP2K1_S218 and GSK3B\n", + "looking for paths in the network with length: 1 for node MAP2K1_S218 and GSK3B\n", + "looking for paths in the network with length: 2 for node MAP2K1_S218 and GSK3B\n", + "looking for paths in the network with length: 3 for node MAP2K1_S218 and GSK3B\n", + "looking for paths in the network with length: 4 for node MAP2K1_S218 and GSK3B\n", + "looking for paths in the network with length: 5 for node MAP2K1_S218 and GSK3B\n", + "looking for paths in the network with length: 6 for node MAP2K1_S218 and GSK3B\n", + "looking for paths in the network with length: 7 for node MAP2K1_S218 and GSK3B\n", + "looking for paths in the network with length: 8 for node MAP2K1_S218 and GSK3B\n", + "looking for paths in the network with length: 9 for node MAP2K1_S218 and GSK3B\n", + "looking for paths in the network with length: 10 for node MAP2K1_S218 and GSK3B\n", + "i_search = 4\n", + "Looking for paths with length: 0 for node MAP2K1_S218 and GSK3B\n", + "i_search = 4\n", + "Looking for paths with length: 1 for node MAP2K1_S218 and GSK3B\n", + "i_search = 4\n", + "Looking for paths with length: 2 for node MAP2K1_S218 and GSK3B\n", + "i_search = 4\n", + "Looking for paths with length: 3 for node MAP2K1_S218 and GSK3B\n", + "i_search = 4\n", + "Looking for paths with length: 4 for node MAP2K1_S218 and GSK3B\n", + "looking for paths in the network with length: 0 for node MAP2K1_S218 and AKT1\n", + "looking for paths in the network with length: 1 for node MAP2K1_S218 and AKT1\n", + "looking for paths in the network with length: 2 for node MAP2K1_S218 and AKT1\n", + "looking for paths in the network with length: 3 for node MAP2K1_S218 and AKT1\n", + "looking for paths in the network with length: 4 for node MAP2K1_S218 and AKT1\n", + "looking for paths in the network with length: 5 for node MAP2K1_S218 and AKT1\n", + "looking for paths in the network with length: 6 for node MAP2K1_S218 and AKT1\n", + "looking for paths in the network with length: 7 for node MAP2K1_S218 and AKT1\n", + "looking for paths in the network with length: 8 for node MAP2K1_S218 and AKT1\n", + "looking for paths in the network with length: 9 for node MAP2K1_S218 and AKT1\n", + "looking for paths in the network with length: 10 for node MAP2K1_S218 and AKT1\n", + "i_search = 4\n", + "Looking for paths with length: 0 for node MAP2K1_S218 and AKT1\n", + "i_search = 4\n", + "Looking for paths with length: 1 for node MAP2K1_S218 and AKT1\n", + "i_search = 4\n", + "Looking for paths with length: 2 for node MAP2K1_S218 and AKT1\n", + "i_search = 4\n", + "Looking for paths with length: 3 for node MAP2K1_S218 and AKT1\n", + "i_search = 4\n", + "Looking for paths with length: 4 for node MAP2K1_S218 and AKT1\n", + "looking for paths in the network with length: 0 for node MAP2K1_S218 and HSPB1\n", + "looking for paths in the network with length: 1 for node MAP2K1_S218 and HSPB1\n", + "looking for paths in the network with length: 2 for node MAP2K1_S218 and HSPB1\n", + "looking for paths in the network with length: 3 for node MAP2K1_S218 and HSPB1\n", + "looking for paths in the network with length: 4 for node MAP2K1_S218 and HSPB1\n", + "looking for paths in the network with length: 5 for node MAP2K1_S218 and HSPB1\n", + "looking for paths in the network with length: 6 for node MAP2K1_S218 and HSPB1\n", + "looking for paths in the network with length: 7 for node MAP2K1_S218 and HSPB1\n", + "looking for paths in the network with length: 8 for node MAP2K1_S218 and HSPB1\n", + "looking for paths in the network with length: 9 for node MAP2K1_S218 and HSPB1\n", + "looking for paths in the network with length: 10 for node MAP2K1_S218 and HSPB1\n", + "i_search = 4\n", + "Looking for paths with length: 0 for node MAP2K1_S218 and HSPB1\n", + "i_search = 4\n", + "Looking for paths with length: 1 for node MAP2K1_S218 and HSPB1\n", + "i_search = 4\n", + "Looking for paths with length: 2 for node MAP2K1_S218 and HSPB1\n", + "i_search = 4\n", + "Looking for paths with length: 3 for node MAP2K1_S218 and HSPB1\n", + "i_search = 4\n", + "Looking for paths with length: 4 for node MAP2K1_S218 and HSPB1\n", + "looking for paths in the network with length: 0 for node MAP2K1_S218 and MAPK14\n", + "looking for paths in the network with length: 1 for node MAP2K1_S218 and MAPK14\n", + "looking for paths in the network with length: 2 for node MAP2K1_S218 and MAPK14\n", + "looking for paths in the network with length: 3 for node MAP2K1_S218 and MAPK14\n", + "looking for paths in the network with length: 4 for node MAP2K1_S218 and MAPK14\n", + "looking for paths in the network with length: 5 for node MAP2K1_S218 and MAPK14\n", + "looking for paths in the network with length: 6 for node MAP2K1_S218 and MAPK14\n", + "looking for paths in the network with length: 7 for node MAP2K1_S218 and MAPK14\n", + "looking for paths in the network with length: 8 for node MAP2K1_S218 and MAPK14\n", + "looking for paths in the network with length: 9 for node MAP2K1_S218 and MAPK14\n", + "looking for paths in the network with length: 10 for node MAP2K1_S218 and MAPK14\n", + "i_search = 4\n", + "Looking for paths with length: 0 for node MAP2K1_S218 and MAPK14\n", + "i_search = 4\n", + "Looking for paths with length: 1 for node MAP2K1_S218 and MAPK14\n", + "i_search = 4\n", + "Looking for paths with length: 2 for node MAP2K1_S218 and MAPK14\n", + "i_search = 4\n", + "Looking for paths with length: 3 for node MAP2K1_S218 and MAPK14\n", + "i_search = 4\n", + "Looking for paths with length: 4 for node MAP2K1_S218 and MAPK14\n", + "looking for paths in the network with length: 0 for node MAP2K1_S218 and MAP2K1\n", + "looking for paths in the network with length: 1 for node MAP2K1_S218 and MAP2K1\n", + "looking for paths in the network with length: 2 for node MAP2K1_S218 and MAP2K1\n", + "looking for paths in the network with length: 3 for node MAP2K1_S218 and MAP2K1\n", + "looking for paths in the network with length: 4 for node MAP2K1_S218 and MAP2K1\n", + "looking for paths in the network with length: 5 for node MAP2K1_S218 and MAP2K1\n", + "looking for paths in the network with length: 6 for node MAP2K1_S218 and MAP2K1\n", + "looking for paths in the network with length: 7 for node MAP2K1_S218 and MAP2K1\n", + "looking for paths in the network with length: 8 for node MAP2K1_S218 and MAP2K1\n", + "looking for paths in the network with length: 9 for node MAP2K1_S218 and MAP2K1\n", + "looking for paths in the network with length: 10 for node MAP2K1_S218 and MAP2K1\n", + "i_search = 4\n", + "Looking for paths with length: 0 for node MAP2K1_S218 and MAP2K1\n", + "i_search = 4\n", + "Looking for paths with length: 1 for node MAP2K1_S218 and MAP2K1\n", + "i_search = 4\n", + "Looking for paths with length: 2 for node MAP2K1_S218 and MAP2K1\n", + "i_search = 4\n", + "Looking for paths with length: 3 for node MAP2K1_S218 and MAP2K1\n", + "i_search = 4\n", + "Looking for paths with length: 4 for node MAP2K1_S218 and MAP2K1\n", + "looking for paths in the network with length: 0 for node MAP2K1_S218 and RPS6KA1\n", + "looking for paths in the network with length: 1 for node MAP2K1_S218 and RPS6KA1\n", + "looking for paths in the network with length: 2 for node MAP2K1_S218 and RPS6KA1\n", + "looking for paths in the network with length: 3 for node MAP2K1_S218 and RPS6KA1\n", + "looking for paths in the network with length: 4 for node MAP2K1_S218 and RPS6KA1\n", + "looking for paths in the network with length: 5 for node MAP2K1_S218 and RPS6KA1\n", + "looking for paths in the network with length: 6 for node MAP2K1_S218 and RPS6KA1\n", + "looking for paths in the network with length: 7 for node MAP2K1_S218 and RPS6KA1\n", + "looking for paths in the network with length: 8 for node MAP2K1_S218 and RPS6KA1\n", + "looking for paths in the network with length: 9 for node MAP2K1_S218 and RPS6KA1\n", + "looking for paths in the network with length: 10 for node MAP2K1_S218 and RPS6KA1\n", + "i_search = 4\n", + "Looking for paths with length: 0 for node MAP2K1_S218 and RPS6KA1\n", + "i_search = 4\n", + "Looking for paths with length: 1 for node MAP2K1_S218 and RPS6KA1\n", + "i_search = 4\n", + "Looking for paths with length: 2 for node MAP2K1_S218 and RPS6KA1\n", + "i_search = 4\n", + "Looking for paths with length: 3 for node MAP2K1_S218 and RPS6KA1\n", + "i_search = 4\n", + "Looking for paths with length: 4 for node MAP2K1_S218 and RPS6KA1\n", + "looking for paths in the network with length: 0 for node MAP2K1_S218 and CREB1\n", + "looking for paths in the network with length: 1 for node MAP2K1_S218 and CREB1\n", + "looking for paths in the network with length: 2 for node MAP2K1_S218 and CREB1\n", + "looking for paths in the network with length: 3 for node MAP2K1_S218 and CREB1\n", + "looking for paths in the network with length: 4 for node MAP2K1_S218 and CREB1\n", + "looking for paths in the network with length: 5 for node MAP2K1_S218 and CREB1\n", + "looking for paths in the network with length: 6 for node MAP2K1_S218 and CREB1\n", + "looking for paths in the network with length: 7 for node MAP2K1_S218 and CREB1\n", + "looking for paths in the network with length: 8 for node MAP2K1_S218 and CREB1\n", + "looking for paths in the network with length: 9 for node MAP2K1_S218 and CREB1\n", + "looking for paths in the network with length: 10 for node MAP2K1_S218 and CREB1\n", + "i_search = 4\n", + "Looking for paths with length: 0 for node MAP2K1_S218 and CREB1\n", + "i_search = 4\n", + "Looking for paths with length: 1 for node MAP2K1_S218 and CREB1\n", + "i_search = 4\n", + "Looking for paths with length: 2 for node MAP2K1_S218 and CREB1\n", + "i_search = 4\n", + "Looking for paths with length: 3 for node MAP2K1_S218 and CREB1\n", + "i_search = 4\n", + "Looking for paths with length: 4 for node MAP2K1_S218 and CREB1\n", + "looking for paths in the network with length: 0 for node MAP2K1_S218 and NFKBIA\n", + "looking for paths in the network with length: 1 for node MAP2K1_S218 and NFKBIA\n", + "looking for paths in the network with length: 2 for node MAP2K1_S218 and NFKBIA\n", + "looking for paths in the network with length: 3 for node MAP2K1_S218 and NFKBIA\n", + "looking for paths in the network with length: 4 for node MAP2K1_S218 and NFKBIA\n", + "looking for paths in the network with length: 5 for node MAP2K1_S218 and NFKBIA\n", + "looking for paths in the network with length: 6 for node MAP2K1_S218 and NFKBIA\n", + "looking for paths in the network with length: 7 for node MAP2K1_S218 and NFKBIA\n", + "looking for paths in the network with length: 8 for node MAP2K1_S218 and NFKBIA\n", + "looking for paths in the network with length: 9 for node MAP2K1_S218 and NFKBIA\n", + "looking for paths in the network with length: 10 for node MAP2K1_S218 and NFKBIA\n", + "i_search = 4\n", + "Looking for paths with length: 0 for node MAP2K1_S218 and NFKBIA\n", + "i_search = 4\n", + "Looking for paths with length: 1 for node MAP2K1_S218 and NFKBIA\n", + "i_search = 4\n", + "Looking for paths with length: 2 for node MAP2K1_S218 and NFKBIA\n", + "i_search = 4\n", + "Looking for paths with length: 3 for node MAP2K1_S218 and NFKBIA\n", + "i_search = 4\n", + "Looking for paths with length: 4 for node MAP2K1_S218 and NFKBIA\n", + "looking for paths in the network with length: 0 for node MAP2K1_S218 and MTOR\n", + "looking for paths in the network with length: 1 for node MAP2K1_S218 and MTOR\n", + "looking for paths in the network with length: 2 for node MAP2K1_S218 and MTOR\n", + "looking for paths in the network with length: 3 for node MAP2K1_S218 and MTOR\n", + "looking for paths in the network with length: 4 for node MAP2K1_S218 and MTOR\n", + "looking for paths in the network with length: 5 for node MAP2K1_S218 and MTOR\n", + "looking for paths in the network with length: 6 for node MAP2K1_S218 and MTOR\n", + "looking for paths in the network with length: 7 for node MAP2K1_S218 and MTOR\n", + "looking for paths in the network with length: 8 for node MAP2K1_S218 and MTOR\n", + "looking for paths in the network with length: 9 for node MAP2K1_S218 and MTOR\n", + "looking for paths in the network with length: 10 for node MAP2K1_S218 and MTOR\n", + "i_search = 4\n", + "Looking for paths with length: 0 for node MAP2K1_S218 and MTOR\n", + "i_search = 4\n", + "Looking for paths with length: 1 for node MAP2K1_S218 and MTOR\n", + "i_search = 4\n", + "Looking for paths with length: 2 for node MAP2K1_S218 and MTOR\n", + "i_search = 4\n", + "Looking for paths with length: 3 for node MAP2K1_S218 and MTOR\n", + "i_search = 4\n", + "Looking for paths with length: 4 for node MAP2K1_S218 and MTOR\n", + "looking for paths in the network with length: 0 for node MAP2K1_S218 and JUN\n", + "looking for paths in the network with length: 1 for node MAP2K1_S218 and JUN\n", + "looking for paths in the network with length: 2 for node MAP2K1_S218 and JUN\n", + "looking for paths in the network with length: 3 for node MAP2K1_S218 and JUN\n", + "looking for paths in the network with length: 4 for node MAP2K1_S218 and JUN\n", + "looking for paths in the network with length: 5 for node MAP2K1_S218 and JUN\n", + "looking for paths in the network with length: 6 for node MAP2K1_S218 and JUN\n", + "looking for paths in the network with length: 7 for node MAP2K1_S218 and JUN\n", + "looking for paths in the network with length: 8 for node MAP2K1_S218 and JUN\n", + "looking for paths in the network with length: 9 for node MAP2K1_S218 and JUN\n", + "looking for paths in the network with length: 10 for node MAP2K1_S218 and JUN\n", + "i_search = 4\n", + "Looking for paths with length: 0 for node MAP2K1_S218 and JUN\n", + "i_search = 4\n", + "Looking for paths with length: 1 for node MAP2K1_S218 and JUN\n", + "i_search = 4\n", + "Looking for paths with length: 2 for node MAP2K1_S218 and JUN\n", + "i_search = 4\n", + "Looking for paths with length: 3 for node MAP2K1_S218 and JUN\n", + "i_search = 4\n", + "Looking for paths with length: 4 for node MAP2K1_S218 and JUN\n", + "looking for paths in the network with length: 0 for node MAP2K1_S218 and EGFR\n", + "looking for paths in the network with length: 1 for node MAP2K1_S218 and EGFR\n", + "looking for paths in the network with length: 2 for node MAP2K1_S218 and EGFR\n", + "looking for paths in the network with length: 3 for node MAP2K1_S218 and EGFR\n", + "looking for paths in the network with length: 4 for node MAP2K1_S218 and EGFR\n", + "looking for paths in the network with length: 5 for node MAP2K1_S218 and EGFR\n", + "looking for paths in the network with length: 6 for node MAP2K1_S218 and EGFR\n", + "looking for paths in the network with length: 7 for node MAP2K1_S218 and EGFR\n", + "looking for paths in the network with length: 8 for node MAP2K1_S218 and EGFR\n", + "looking for paths in the network with length: 9 for node MAP2K1_S218 and EGFR\n", + "looking for paths in the network with length: 10 for node MAP2K1_S218 and EGFR\n", + "i_search = 4\n", + "Looking for paths with length: 0 for node MAP2K1_S218 and EGFR\n", + "i_search = 4\n", + "Looking for paths with length: 1 for node MAP2K1_S218 and EGFR\n", + "i_search = 4\n", + "Looking for paths with length: 2 for node MAP2K1_S218 and EGFR\n", + "i_search = 4\n", + "Looking for paths with length: 3 for node MAP2K1_S218 and EGFR\n", + "i_search = 4\n", + "Looking for paths with length: 4 for node MAP2K1_S218 and EGFR\n", + "looking for paths in the network with length: 0 for node MAP2K1_S218 and MAPK3\n", + "looking for paths in the network with length: 1 for node MAP2K1_S218 and MAPK3\n", + "looking for paths in the network with length: 2 for node MAP2K1_S218 and MAPK3\n", + "looking for paths in the network with length: 3 for node MAP2K1_S218 and MAPK3\n", + "looking for paths in the network with length: 4 for node MAP2K1_S218 and MAPK3\n", + "looking for paths in the network with length: 5 for node MAP2K1_S218 and MAPK3\n", + "looking for paths in the network with length: 6 for node MAP2K1_S218 and MAPK3\n", + "looking for paths in the network with length: 7 for node MAP2K1_S218 and MAPK3\n", + "looking for paths in the network with length: 8 for node MAP2K1_S218 and MAPK3\n", + "looking for paths in the network with length: 9 for node MAP2K1_S218 and MAPK3\n", + "looking for paths in the network with length: 10 for node MAP2K1_S218 and MAPK3\n", + "i_search = 4\n", + "Looking for paths with length: 0 for node MAP2K1_S218 and MAPK3\n", + "i_search = 4\n", + "Looking for paths with length: 1 for node MAP2K1_S218 and MAPK3\n", + "i_search = 4\n", + "Looking for paths with length: 2 for node MAP2K1_S218 and MAPK3\n", + "i_search = 4\n", + "Looking for paths with length: 3 for node MAP2K1_S218 and MAPK3\n", + "i_search = 4\n", + "Looking for paths with length: 4 for node MAP2K1_S218 and MAPK3\n", + "looking for paths in the network with length: 0 for node MAP2K1_S218 and PTPN11\n", + "looking for paths in the network with length: 1 for node MAP2K1_S218 and PTPN11\n", + "looking for paths in the network with length: 2 for node MAP2K1_S218 and PTPN11\n", + "looking for paths in the network with length: 3 for node MAP2K1_S218 and PTPN11\n", + "looking for paths in the network with length: 4 for node MAP2K1_S218 and PTPN11\n", + "looking for paths in the network with length: 5 for node MAP2K1_S218 and PTPN11\n", + "looking for paths in the network with length: 6 for node MAP2K1_S218 and PTPN11\n", + "looking for paths in the network with length: 7 for node MAP2K1_S218 and PTPN11\n", + "looking for paths in the network with length: 8 for node MAP2K1_S218 and PTPN11\n", + "looking for paths in the network with length: 9 for node MAP2K1_S218 and PTPN11\n", + "looking for paths in the network with length: 10 for node MAP2K1_S218 and PTPN11\n", + "i_search = 4\n", + "Looking for paths with length: 0 for node MAP2K1_S218 and PTPN11\n", + "i_search = 4\n", + "Looking for paths with length: 1 for node MAP2K1_S218 and PTPN11\n", + "i_search = 4\n", + "Looking for paths with length: 2 for node MAP2K1_S218 and PTPN11\n", + "i_search = 4\n", + "Looking for paths with length: 3 for node MAP2K1_S218 and PTPN11\n", + "i_search = 4\n", + "Looking for paths with length: 4 for node MAP2K1_S218 and PTPN11\n", + "looking for paths in the network with length: 0 for node MAP2K1_S218 and STAT3\n", + "looking for paths in the network with length: 1 for node MAP2K1_S218 and STAT3\n", + "looking for paths in the network with length: 2 for node MAP2K1_S218 and STAT3\n", + "looking for paths in the network with length: 3 for node MAP2K1_S218 and STAT3\n", + "looking for paths in the network with length: 4 for node MAP2K1_S218 and STAT3\n", + "looking for paths in the network with length: 5 for node MAP2K1_S218 and STAT3\n", + "looking for paths in the network with length: 6 for node MAP2K1_S218 and STAT3\n", + "looking for paths in the network with length: 7 for node MAP2K1_S218 and STAT3\n", + "looking for paths in the network with length: 8 for node MAP2K1_S218 and STAT3\n", + "looking for paths in the network with length: 9 for node MAP2K1_S218 and STAT3\n", + "looking for paths in the network with length: 10 for node MAP2K1_S218 and STAT3\n", + "i_search = 4\n", + "Looking for paths with length: 0 for node MAP2K1_S218 and STAT3\n", + "i_search = 4\n", + "Looking for paths with length: 1 for node MAP2K1_S218 and STAT3\n", + "i_search = 4\n", + "Looking for paths with length: 2 for node MAP2K1_S218 and STAT3\n", + "i_search = 4\n", + "Looking for paths with length: 3 for node MAP2K1_S218 and STAT3\n", + "i_search = 4\n", + "Looking for paths with length: 4 for node MAP2K1_S218 and STAT3\n", + "looking for paths in the network with length: 0 for node MAP2K1_S218 and CHEK2\n", + "looking for paths in the network with length: 1 for node MAP2K1_S218 and CHEK2\n", + "looking for paths in the network with length: 2 for node MAP2K1_S218 and CHEK2\n", + "looking for paths in the network with length: 3 for node MAP2K1_S218 and CHEK2\n", + "looking for paths in the network with length: 4 for node MAP2K1_S218 and CHEK2\n", + "looking for paths in the network with length: 5 for node MAP2K1_S218 and CHEK2\n", + "looking for paths in the network with length: 6 for node MAP2K1_S218 and CHEK2\n", + "looking for paths in the network with length: 7 for node MAP2K1_S218 and CHEK2\n", + "looking for paths in the network with length: 8 for node MAP2K1_S218 and CHEK2\n", + "looking for paths in the network with length: 9 for node MAP2K1_S218 and CHEK2\n", + "looking for paths in the network with length: 10 for node MAP2K1_S218 and CHEK2\n", + "i_search = 4\n", + "Looking for paths with length: 0 for node MAP2K1_S218 and CHEK2\n", + "i_search = 4\n", + "Looking for paths with length: 1 for node MAP2K1_S218 and CHEK2\n", + "i_search = 4\n", + "Looking for paths with length: 2 for node MAP2K1_S218 and CHEK2\n", + "i_search = 4\n", + "Looking for paths with length: 3 for node MAP2K1_S218 and CHEK2\n", + "i_search = 4\n", + "Looking for paths with length: 4 for node MAP2K1_S218 and CHEK2\n", + "looking for paths in the network with length: 0 for node MAP2K1_S218 and RELA\n", + "looking for paths in the network with length: 1 for node MAP2K1_S218 and RELA\n", + "looking for paths in the network with length: 2 for node MAP2K1_S218 and RELA\n", + "looking for paths in the network with length: 3 for node MAP2K1_S218 and RELA\n", + "looking for paths in the network with length: 4 for node MAP2K1_S218 and RELA\n", + "looking for paths in the network with length: 5 for node MAP2K1_S218 and RELA\n", + "looking for paths in the network with length: 6 for node MAP2K1_S218 and RELA\n", + "looking for paths in the network with length: 7 for node MAP2K1_S218 and RELA\n", + "looking for paths in the network with length: 8 for node MAP2K1_S218 and RELA\n", + "looking for paths in the network with length: 9 for node MAP2K1_S218 and RELA\n", + "looking for paths in the network with length: 10 for node MAP2K1_S218 and RELA\n", + "i_search = 4\n", + "Looking for paths with length: 0 for node MAP2K1_S218 and RELA\n", + "i_search = 4\n", + "Looking for paths with length: 1 for node MAP2K1_S218 and RELA\n", + "i_search = 4\n", + "Looking for paths with length: 2 for node MAP2K1_S218 and RELA\n", + "i_search = 4\n", + "Looking for paths with length: 3 for node MAP2K1_S218 and RELA\n", + "i_search = 4\n", + "Looking for paths with length: 4 for node MAP2K1_S218 and RELA\n", + "looking for paths in the network with length: 0 for node MAP2K1_S218 and MARCKS\n", + "looking for paths in the network with length: 1 for node MAP2K1_S218 and MARCKS\n", + "looking for paths in the network with length: 2 for node MAP2K1_S218 and MARCKS\n", + "looking for paths in the network with length: 3 for node MAP2K1_S218 and MARCKS\n", + "looking for paths in the network with length: 4 for node MAP2K1_S218 and MARCKS\n", + "looking for paths in the network with length: 5 for node MAP2K1_S218 and MARCKS\n", + "looking for paths in the network with length: 6 for node MAP2K1_S218 and MARCKS\n", + "looking for paths in the network with length: 7 for node MAP2K1_S218 and MARCKS\n", + "looking for paths in the network with length: 8 for node MAP2K1_S218 and MARCKS\n", + "looking for paths in the network with length: 9 for node MAP2K1_S218 and MARCKS\n", + "looking for paths in the network with length: 10 for node MAP2K1_S218 and MARCKS\n", + "i_search = 4\n", + "Looking for paths with length: 0 for node MAP2K1_S218 and MARCKS\n", + "i_search = 4\n", + "Looking for paths with length: 1 for node MAP2K1_S218 and MARCKS\n", + "i_search = 4\n", + "Looking for paths with length: 2 for node MAP2K1_S218 and MARCKS\n", + "i_search = 4\n", + "Looking for paths with length: 3 for node MAP2K1_S218 and MARCKS\n", + "i_search = 4\n", + "Looking for paths with length: 4 for node MAP2K1_S218 and MARCKS\n", + "looking for paths in the network with length: 0 for node MAP2K1_S222 and RPS6KA1_S380\n", + "looking for paths in the network with length: 1 for node MAP2K1_S222 and RPS6KA1_S380\n", + "looking for paths in the network with length: 2 for node MAP2K1_S222 and RPS6KA1_S380\n", + "looking for paths in the network with length: 3 for node MAP2K1_S222 and RPS6KA1_S380\n", + "looking for paths in the network with length: 4 for node MAP2K1_S222 and RPS6KA1_S380\n", + "Found a path!\n", + "[['MAP2K1_S222', 'MAP2K1', 'MAPK3_Y204', 'MAPK3', 'RPS6KA1_S380'], ['MAP2K1_S222', 'MAP2K1', 'MAPK3_T202', 'MAPK3', 'RPS6KA1_S380'], ['MAP2K1_S222', 'MAP2K1', 'MAPK3_T207', 'MAPK3', 'RPS6KA1_S380']]\n", + "looking for paths in the network with length: 0 for node MAP2K1_S222 and CREB1_S133\n", + "looking for paths in the network with length: 1 for node MAP2K1_S222 and CREB1_S133\n", + "looking for paths in the network with length: 2 for node MAP2K1_S222 and CREB1_S133\n", + "looking for paths in the network with length: 3 for node MAP2K1_S222 and CREB1_S133\n", + "looking for paths in the network with length: 4 for node MAP2K1_S222 and CREB1_S133\n", + "looking for paths in the network with length: 5 for node MAP2K1_S222 and CREB1_S133\n", + "looking for paths in the network with length: 6 for node MAP2K1_S222 and CREB1_S133\n", + "looking for paths in the network with length: 7 for node MAP2K1_S222 and CREB1_S133\n", + "looking for paths in the network with length: 8 for node MAP2K1_S222 and CREB1_S133\n", + "looking for paths in the network with length: 9 for node MAP2K1_S222 and CREB1_S133\n", + "looking for paths in the network with length: 10 for node MAP2K1_S222 and CREB1_S133\n", + "i_search = 4\n", + "Looking for paths with length: 0 for node MAP2K1_S222 and CREB1_S133\n", + "i_search = 4\n", + "Looking for paths with length: 1 for node MAP2K1_S222 and CREB1_S133\n", + "i_search = 4\n", + "Looking for paths with length: 2 for node MAP2K1_S222 and CREB1_S133\n", + "i_search = 4\n", + "Looking for paths with length: 3 for node MAP2K1_S222 and CREB1_S133\n", + "i_search = 4\n", + "Looking for paths with length: 4 for node MAP2K1_S222 and CREB1_S133\n", + "looking for paths in the network with length: 0 for node MAP2K1_S222 and NFKBIA_S32\n", + "looking for paths in the network with length: 1 for node MAP2K1_S222 and NFKBIA_S32\n", + "looking for paths in the network with length: 2 for node MAP2K1_S222 and NFKBIA_S32\n", + "looking for paths in the network with length: 3 for node MAP2K1_S222 and NFKBIA_S32\n", + "looking for paths in the network with length: 4 for node MAP2K1_S222 and NFKBIA_S32\n", + "looking for paths in the network with length: 5 for node MAP2K1_S222 and NFKBIA_S32\n", + "looking for paths in the network with length: 6 for node MAP2K1_S222 and NFKBIA_S32\n", + "looking for paths in the network with length: 7 for node MAP2K1_S222 and NFKBIA_S32\n", + "looking for paths in the network with length: 8 for node MAP2K1_S222 and NFKBIA_S32\n", + "looking for paths in the network with length: 9 for node MAP2K1_S222 and NFKBIA_S32\n", + "looking for paths in the network with length: 10 for node MAP2K1_S222 and NFKBIA_S32\n", + "i_search = 4\n", + "Looking for paths with length: 0 for node MAP2K1_S222 and NFKBIA_S32\n", + "i_search = 4\n", + "Looking for paths with length: 1 for node MAP2K1_S222 and NFKBIA_S32\n", + "i_search = 4\n", + "Looking for paths with length: 2 for node MAP2K1_S222 and NFKBIA_S32\n", + "i_search = 4\n", + "Looking for paths with length: 3 for node MAP2K1_S222 and NFKBIA_S32\n", + "i_search = 4\n", + "Looking for paths with length: 4 for node MAP2K1_S222 and NFKBIA_S32\n", + "looking for paths in the network with length: 0 for node MAP2K1_S222 and NFKBIA_S36\n", + "looking for paths in the network with length: 1 for node MAP2K1_S222 and NFKBIA_S36\n", + "looking for paths in the network with length: 2 for node MAP2K1_S222 and NFKBIA_S36\n", + "looking for paths in the network with length: 3 for node MAP2K1_S222 and NFKBIA_S36\n", + "looking for paths in the network with length: 4 for node MAP2K1_S222 and NFKBIA_S36\n", + "looking for paths in the network with length: 5 for node MAP2K1_S222 and NFKBIA_S36\n", + "looking for paths in the network with length: 6 for node MAP2K1_S222 and NFKBIA_S36\n", + "looking for paths in the network with length: 7 for node MAP2K1_S222 and NFKBIA_S36\n", + "looking for paths in the network with length: 8 for node MAP2K1_S222 and NFKBIA_S36\n", + "looking for paths in the network with length: 9 for node MAP2K1_S222 and NFKBIA_S36\n", + "looking for paths in the network with length: 10 for node MAP2K1_S222 and NFKBIA_S36\n", + "i_search = 4\n", + "Looking for paths with length: 0 for node MAP2K1_S222 and NFKBIA_S36\n", + "i_search = 4\n", + "Looking for paths with length: 1 for node MAP2K1_S222 and NFKBIA_S36\n", + "i_search = 4\n", + "Looking for paths with length: 2 for node MAP2K1_S222 and NFKBIA_S36\n", + "i_search = 4\n", + "Looking for paths with length: 3 for node MAP2K1_S222 and NFKBIA_S36\n", + "i_search = 4\n", + "Looking for paths with length: 4 for node MAP2K1_S222 and NFKBIA_S36\n", + "looking for paths in the network with length: 0 for node MAP2K1_S222 and MTOR_S2448\n", + "looking for paths in the network with length: 1 for node MAP2K1_S222 and MTOR_S2448\n", + "looking for paths in the network with length: 2 for node MAP2K1_S222 and MTOR_S2448\n", + "looking for paths in the network with length: 3 for node MAP2K1_S222 and MTOR_S2448\n", + "looking for paths in the network with length: 4 for node MAP2K1_S222 and MTOR_S2448\n", + "looking for paths in the network with length: 5 for node MAP2K1_S222 and MTOR_S2448\n", + "looking for paths in the network with length: 6 for node MAP2K1_S222 and MTOR_S2448\n", + "looking for paths in the network with length: 7 for node MAP2K1_S222 and MTOR_S2448\n", + "looking for paths in the network with length: 8 for node MAP2K1_S222 and MTOR_S2448\n", + "looking for paths in the network with length: 9 for node MAP2K1_S222 and MTOR_S2448\n", + "looking for paths in the network with length: 10 for node MAP2K1_S222 and MTOR_S2448\n", + "i_search = 4\n", + "Looking for paths with length: 0 for node MAP2K1_S222 and MTOR_S2448\n", + "i_search = 4\n", + "Looking for paths with length: 1 for node MAP2K1_S222 and MTOR_S2448\n", + "i_search = 4\n", + "Looking for paths with length: 2 for node MAP2K1_S222 and MTOR_S2448\n", + "i_search = 4\n", + "Looking for paths with length: 3 for node MAP2K1_S222 and MTOR_S2448\n", + "i_search = 4\n", + "Looking for paths with length: 4 for node MAP2K1_S222 and MTOR_S2448\n", + "looking for paths in the network with length: 0 for node MAP2K1_S222 and JUN_S63\n", + "looking for paths in the network with length: 1 for node MAP2K1_S222 and JUN_S63\n", + "looking for paths in the network with length: 2 for node MAP2K1_S222 and JUN_S63\n", + "looking for paths in the network with length: 3 for node MAP2K1_S222 and JUN_S63\n", + "looking for paths in the network with length: 4 for node MAP2K1_S222 and JUN_S63\n", + "Found a path!\n", + "[['MAP2K1_S222', 'MAP2K1', 'MAPK1_Y187', 'MAPK1', 'JUN_S63'], ['MAP2K1_S222', 'MAP2K1', 'MAPK1_T185', 'MAPK1', 'JUN_S63'], ['MAP2K1_S222', 'MAP2K1', 'MAPK3_Y204', 'MAPK3', 'JUN_S63'], ['MAP2K1_S222', 'MAP2K1', 'MAPK3_T202', 'MAPK3', 'JUN_S63'], ['MAP2K1_S222', 'MAP2K1', 'MAPK3_T207', 'MAPK3', 'JUN_S63']]\n", + "looking for paths in the network with length: 0 for node MAP2K1_S222 and EGFR_Y1068\n", + "looking for paths in the network with length: 1 for node MAP2K1_S222 and EGFR_Y1068\n", + "looking for paths in the network with length: 2 for node MAP2K1_S222 and EGFR_Y1068\n", + "looking for paths in the network with length: 3 for node MAP2K1_S222 and EGFR_Y1068\n", + "looking for paths in the network with length: 4 for node MAP2K1_S222 and EGFR_Y1068\n", + "looking for paths in the network with length: 5 for node MAP2K1_S222 and EGFR_Y1068\n", + "looking for paths in the network with length: 6 for node MAP2K1_S222 and EGFR_Y1068\n", + "looking for paths in the network with length: 7 for node MAP2K1_S222 and EGFR_Y1068\n", + "looking for paths in the network with length: 8 for node MAP2K1_S222 and EGFR_Y1068\n", + "looking for paths in the network with length: 9 for node MAP2K1_S222 and EGFR_Y1068\n", + "looking for paths in the network with length: 10 for node MAP2K1_S222 and EGFR_Y1068\n", + "i_search = 4\n", + "Looking for paths with length: 0 for node MAP2K1_S222 and EGFR_Y1068\n", + "i_search = 4\n", + "Looking for paths with length: 1 for node MAP2K1_S222 and EGFR_Y1068\n", + "i_search = 4\n", + "Looking for paths with length: 2 for node MAP2K1_S222 and EGFR_Y1068\n", + "i_search = 4\n", + "Looking for paths with length: 3 for node MAP2K1_S222 and EGFR_Y1068\n", + "i_search = 4\n", + "Looking for paths with length: 4 for node MAP2K1_S222 and EGFR_Y1068\n", + "looking for paths in the network with length: 0 for node MAP2K1_S222 and MAPK3_T202\n", + "looking for paths in the network with length: 1 for node MAP2K1_S222 and MAPK3_T202\n", + "looking for paths in the network with length: 2 for node MAP2K1_S222 and MAPK3_T202\n", + "Found a path!\n", + "[['MAP2K1_S222', 'MAP2K1', 'MAPK3_T202']]\n", + "looking for paths in the network with length: 0 for node MAP2K1_S222 and MAPK3_Y204\n", + "looking for paths in the network with length: 1 for node MAP2K1_S222 and MAPK3_Y204\n", + "looking for paths in the network with length: 2 for node MAP2K1_S222 and MAPK3_Y204\n", + "Found a path!\n", + "[['MAP2K1_S222', 'MAP2K1', 'MAPK3_Y204']]\n", + "looking for paths in the network with length: 0 for node MAP2K1_S222 and PTPN11_Y542\n", + "looking for paths in the network with length: 1 for node MAP2K1_S222 and PTPN11_Y542\n", + "looking for paths in the network with length: 2 for node MAP2K1_S222 and PTPN11_Y542\n", + "looking for paths in the network with length: 3 for node MAP2K1_S222 and PTPN11_Y542\n", + "looking for paths in the network with length: 4 for node MAP2K1_S222 and PTPN11_Y542\n", + "looking for paths in the network with length: 5 for node MAP2K1_S222 and PTPN11_Y542\n", + "looking for paths in the network with length: 6 for node MAP2K1_S222 and PTPN11_Y542\n", + "looking for paths in the network with length: 7 for node MAP2K1_S222 and PTPN11_Y542\n", + "looking for paths in the network with length: 8 for node MAP2K1_S222 and PTPN11_Y542\n", + "looking for paths in the network with length: 9 for node MAP2K1_S222 and PTPN11_Y542\n", + "looking for paths in the network with length: 10 for node MAP2K1_S222 and PTPN11_Y542\n", + "i_search = 4\n", + "Looking for paths with length: 0 for node MAP2K1_S222 and PTPN11_Y542\n", + "i_search = 4\n", + "Looking for paths with length: 1 for node MAP2K1_S222 and PTPN11_Y542\n", + "i_search = 4\n", + "Looking for paths with length: 2 for node MAP2K1_S222 and PTPN11_Y542\n", + "i_search = 4\n", + "Looking for paths with length: 3 for node MAP2K1_S222 and PTPN11_Y542\n", + "i_search = 4\n", + "Looking for paths with length: 4 for node MAP2K1_S222 and PTPN11_Y542\n", + "looking for paths in the network with length: 0 for node MAP2K1_S222 and STAT3_Y705\n", + "looking for paths in the network with length: 1 for node MAP2K1_S222 and STAT3_Y705\n", + "looking for paths in the network with length: 2 for node MAP2K1_S222 and STAT3_Y705\n", + "looking for paths in the network with length: 3 for node MAP2K1_S222 and STAT3_Y705\n", + "looking for paths in the network with length: 4 for node MAP2K1_S222 and STAT3_Y705\n", + "looking for paths in the network with length: 5 for node MAP2K1_S222 and STAT3_Y705\n", + "looking for paths in the network with length: 6 for node MAP2K1_S222 and STAT3_Y705\n", + "looking for paths in the network with length: 7 for node MAP2K1_S222 and STAT3_Y705\n", + "looking for paths in the network with length: 8 for node MAP2K1_S222 and STAT3_Y705\n", + "Found a path!\n", + "[['MAP2K1_S222', 'MAP2K1', 'MAPK3_Y204', 'MAPK3', 'GSK3B_T43', 'GSK3B', 'SRC_S493', 'SRC', 'STAT3_Y705'], ['MAP2K1_S222', 'MAP2K1', 'MAPK3_Y204', 'MAPK3', 'GSK3B_T43', 'GSK3B', 'SRC_S51', 'SRC', 'STAT3_Y705'], ['MAP2K1_S222', 'MAP2K1', 'MAPK3_Y204', 'MAPK3', 'GSK3B_T43', 'GSK3B', 'SRC_S43', 'SRC', 'STAT3_Y705'], ['MAP2K1_S222', 'MAP2K1', 'MAPK3_Y204', 'MAPK3', 'GSK3B_T43', 'GSK3B', 'SRC_Y419', 'SRC', 'STAT3_Y705'], ['MAP2K1_S222', 'MAP2K1', 'MAPK3_T202', 'MAPK3', 'GSK3B_T43', 'GSK3B', 'SRC_S493', 'SRC', 'STAT3_Y705'], ['MAP2K1_S222', 'MAP2K1', 'MAPK3_T202', 'MAPK3', 'GSK3B_T43', 'GSK3B', 'SRC_S51', 'SRC', 'STAT3_Y705'], ['MAP2K1_S222', 'MAP2K1', 'MAPK3_T202', 'MAPK3', 'GSK3B_T43', 'GSK3B', 'SRC_S43', 'SRC', 'STAT3_Y705'], ['MAP2K1_S222', 'MAP2K1', 'MAPK3_T202', 'MAPK3', 'GSK3B_T43', 'GSK3B', 'SRC_Y419', 'SRC', 'STAT3_Y705'], ['MAP2K1_S222', 'MAP2K1', 'MAPK3_T207', 'MAPK3', 'GSK3B_T43', 'GSK3B', 'SRC_S493', 'SRC', 'STAT3_Y705'], ['MAP2K1_S222', 'MAP2K1', 'MAPK3_T207', 'MAPK3', 'GSK3B_T43', 'GSK3B', 'SRC_S51', 'SRC', 'STAT3_Y705'], ['MAP2K1_S222', 'MAP2K1', 'MAPK3_T207', 'MAPK3', 'GSK3B_T43', 'GSK3B', 'SRC_S43', 'SRC', 'STAT3_Y705'], ['MAP2K1_S222', 'MAP2K1', 'MAPK3_T207', 'MAPK3', 'GSK3B_T43', 'GSK3B', 'SRC_Y419', 'SRC', 'STAT3_Y705']]\n", + "looking for paths in the network with length: 0 for node MAP2K1_S222 and CHEK2_T68\n", + "looking for paths in the network with length: 1 for node MAP2K1_S222 and CHEK2_T68\n", + "looking for paths in the network with length: 2 for node MAP2K1_S222 and CHEK2_T68\n", + "looking for paths in the network with length: 3 for node MAP2K1_S222 and CHEK2_T68\n", + "looking for paths in the network with length: 4 for node MAP2K1_S222 and CHEK2_T68\n", + "looking for paths in the network with length: 5 for node MAP2K1_S222 and CHEK2_T68\n", + "looking for paths in the network with length: 6 for node MAP2K1_S222 and CHEK2_T68\n", + "looking for paths in the network with length: 7 for node MAP2K1_S222 and CHEK2_T68\n", + "looking for paths in the network with length: 8 for node MAP2K1_S222 and CHEK2_T68\n", + "looking for paths in the network with length: 9 for node MAP2K1_S222 and CHEK2_T68\n", + "looking for paths in the network with length: 10 for node MAP2K1_S222 and CHEK2_T68\n", + "i_search = 4\n", + "Looking for paths with length: 0 for node MAP2K1_S222 and CHEK2_T68\n", + "i_search = 4\n", + "Looking for paths with length: 1 for node MAP2K1_S222 and CHEK2_T68\n", + "i_search = 4\n", + "Looking for paths with length: 2 for node MAP2K1_S222 and CHEK2_T68\n", + "i_search = 4\n", + "Looking for paths with length: 3 for node MAP2K1_S222 and CHEK2_T68\n", + "i_search = 4\n", + "Looking for paths with length: 4 for node MAP2K1_S222 and CHEK2_T68\n", + "looking for paths in the network with length: 0 for node MAP2K1_S222 and RELA_S536\n", + "looking for paths in the network with length: 1 for node MAP2K1_S222 and RELA_S536\n", + "looking for paths in the network with length: 2 for node MAP2K1_S222 and RELA_S536\n", + "looking for paths in the network with length: 3 for node MAP2K1_S222 and RELA_S536\n", + "looking for paths in the network with length: 4 for node MAP2K1_S222 and RELA_S536\n", + "looking for paths in the network with length: 5 for node MAP2K1_S222 and RELA_S536\n", + "looking for paths in the network with length: 6 for node MAP2K1_S222 and RELA_S536\n", + "looking for paths in the network with length: 7 for node MAP2K1_S222 and RELA_S536\n", + "looking for paths in the network with length: 8 for node MAP2K1_S222 and RELA_S536\n", + "Found a path!\n", + "[['MAP2K1_S222', 'MAP2K1', 'MAPK3_Y204', 'MAPK3', 'GSK3B_T43', 'GSK3B', 'TBK1_S172', 'TBK1', 'RELA_S536'], ['MAP2K1_S222', 'MAP2K1', 'MAPK3_T202', 'MAPK3', 'GSK3B_T43', 'GSK3B', 'TBK1_S172', 'TBK1', 'RELA_S536'], ['MAP2K1_S222', 'MAP2K1', 'MAPK3_T207', 'MAPK3', 'GSK3B_T43', 'GSK3B', 'TBK1_S172', 'TBK1', 'RELA_S536']]\n", + "looking for paths in the network with length: 0 for node MAP2K1_S222 and MARCKS_S170\n", + "looking for paths in the network with length: 1 for node MAP2K1_S222 and MARCKS_S170\n", + "looking for paths in the network with length: 2 for node MAP2K1_S222 and MARCKS_S170\n", + "looking for paths in the network with length: 3 for node MAP2K1_S222 and MARCKS_S170\n", + "looking for paths in the network with length: 4 for node MAP2K1_S222 and MARCKS_S170\n", + "looking for paths in the network with length: 5 for node MAP2K1_S222 and MARCKS_S170\n", + "looking for paths in the network with length: 6 for node MAP2K1_S222 and MARCKS_S170\n", + "looking for paths in the network with length: 7 for node MAP2K1_S222 and MARCKS_S170\n", + "looking for paths in the network with length: 8 for node MAP2K1_S222 and MARCKS_S170\n", + "looking for paths in the network with length: 9 for node MAP2K1_S222 and MARCKS_S170\n", + "looking for paths in the network with length: 10 for node MAP2K1_S222 and MARCKS_S170\n", + "i_search = 4\n", + "Looking for paths with length: 0 for node MAP2K1_S222 and MARCKS_S170\n", + "i_search = 4\n", + "Looking for paths with length: 1 for node MAP2K1_S222 and MARCKS_S170\n", + "i_search = 4\n", + "Looking for paths with length: 2 for node MAP2K1_S222 and MARCKS_S170\n", + "i_search = 4\n", + "Looking for paths with length: 3 for node MAP2K1_S222 and MARCKS_S170\n", + "i_search = 4\n", + "Looking for paths with length: 4 for node MAP2K1_S222 and MARCKS_S170\n", + "looking for paths in the network with length: 0 for node MAP2K1_S222 and SMAD3\n", + "looking for paths in the network with length: 1 for node MAP2K1_S222 and SMAD3\n", + "looking for paths in the network with length: 2 for node MAP2K1_S222 and SMAD3\n", + "looking for paths in the network with length: 3 for node MAP2K1_S222 and SMAD3\n", + "looking for paths in the network with length: 4 for node MAP2K1_S222 and SMAD3\n", + "looking for paths in the network with length: 5 for node MAP2K1_S222 and SMAD3\n", + "looking for paths in the network with length: 6 for node MAP2K1_S222 and SMAD3\n", + "looking for paths in the network with length: 7 for node MAP2K1_S222 and SMAD3\n", + "looking for paths in the network with length: 8 for node MAP2K1_S222 and SMAD3\n", + "looking for paths in the network with length: 9 for node MAP2K1_S222 and SMAD3\n", + "looking for paths in the network with length: 10 for node MAP2K1_S222 and SMAD3\n", + "i_search = 4\n", + "Looking for paths with length: 0 for node MAP2K1_S222 and SMAD3\n", + "i_search = 4\n", + "Looking for paths with length: 1 for node MAP2K1_S222 and SMAD3\n", + "i_search = 4\n", + "Looking for paths with length: 2 for node MAP2K1_S222 and SMAD3\n", + "i_search = 4\n", + "Looking for paths with length: 3 for node MAP2K1_S222 and SMAD3\n", + "i_search = 4\n", + "Looking for paths with length: 4 for node MAP2K1_S222 and SMAD3\n", + "looking for paths in the network with length: 0 for node MAP2K1_S222 and TP53\n", + "looking for paths in the network with length: 1 for node MAP2K1_S222 and TP53\n", + "looking for paths in the network with length: 2 for node MAP2K1_S222 and TP53\n", + "looking for paths in the network with length: 3 for node MAP2K1_S222 and TP53\n", + "looking for paths in the network with length: 4 for node MAP2K1_S222 and TP53\n", + "looking for paths in the network with length: 5 for node MAP2K1_S222 and TP53\n", + "looking for paths in the network with length: 6 for node MAP2K1_S222 and TP53\n", + "looking for paths in the network with length: 7 for node MAP2K1_S222 and TP53\n", + "looking for paths in the network with length: 8 for node MAP2K1_S222 and TP53\n", + "looking for paths in the network with length: 9 for node MAP2K1_S222 and TP53\n", + "looking for paths in the network with length: 10 for node MAP2K1_S222 and TP53\n", + "i_search = 4\n", + "Looking for paths with length: 0 for node MAP2K1_S222 and TP53\n", + "i_search = 4\n", + "Looking for paths with length: 1 for node MAP2K1_S222 and TP53\n", + "i_search = 4\n", + "Looking for paths with length: 2 for node MAP2K1_S222 and TP53\n", + "i_search = 4\n", + "Looking for paths with length: 3 for node MAP2K1_S222 and TP53\n", + "i_search = 4\n", + "Looking for paths with length: 4 for node MAP2K1_S222 and TP53\n", + "looking for paths in the network with length: 0 for node MAP2K1_S222 and AKT1S1\n", + "looking for paths in the network with length: 1 for node MAP2K1_S222 and AKT1S1\n", + "looking for paths in the network with length: 2 for node MAP2K1_S222 and AKT1S1\n", + "looking for paths in the network with length: 3 for node MAP2K1_S222 and AKT1S1\n", + "looking for paths in the network with length: 4 for node MAP2K1_S222 and AKT1S1\n", + "looking for paths in the network with length: 5 for node MAP2K1_S222 and AKT1S1\n", + "looking for paths in the network with length: 6 for node MAP2K1_S222 and AKT1S1\n", + "looking for paths in the network with length: 7 for node MAP2K1_S222 and AKT1S1\n", + "looking for paths in the network with length: 8 for node MAP2K1_S222 and AKT1S1\n", + "looking for paths in the network with length: 9 for node MAP2K1_S222 and AKT1S1\n", + "looking for paths in the network with length: 10 for node MAP2K1_S222 and AKT1S1\n", + "i_search = 4\n", + "Looking for paths with length: 0 for node MAP2K1_S222 and AKT1S1\n", + "i_search = 4\n", + "Looking for paths with length: 1 for node MAP2K1_S222 and AKT1S1\n", + "i_search = 4\n", + "Looking for paths with length: 2 for node MAP2K1_S222 and AKT1S1\n", + "i_search = 4\n", + "Looking for paths with length: 3 for node MAP2K1_S222 and AKT1S1\n", + "i_search = 4\n", + "Looking for paths with length: 4 for node MAP2K1_S222 and AKT1S1\n", + "looking for paths in the network with length: 0 for node MAP2K1_S222 and GSK3B\n", + "looking for paths in the network with length: 1 for node MAP2K1_S222 and GSK3B\n", + "looking for paths in the network with length: 2 for node MAP2K1_S222 and GSK3B\n", + "looking for paths in the network with length: 3 for node MAP2K1_S222 and GSK3B\n", + "looking for paths in the network with length: 4 for node MAP2K1_S222 and GSK3B\n", + "looking for paths in the network with length: 5 for node MAP2K1_S222 and GSK3B\n", + "looking for paths in the network with length: 6 for node MAP2K1_S222 and GSK3B\n", + "looking for paths in the network with length: 7 for node MAP2K1_S222 and GSK3B\n", + "looking for paths in the network with length: 8 for node MAP2K1_S222 and GSK3B\n", + "looking for paths in the network with length: 9 for node MAP2K1_S222 and GSK3B\n", + "looking for paths in the network with length: 10 for node MAP2K1_S222 and GSK3B\n", + "i_search = 4\n", + "Looking for paths with length: 0 for node MAP2K1_S222 and GSK3B\n", + "i_search = 4\n", + "Looking for paths with length: 1 for node MAP2K1_S222 and GSK3B\n", + "i_search = 4\n", + "Looking for paths with length: 2 for node MAP2K1_S222 and GSK3B\n", + "i_search = 4\n", + "Looking for paths with length: 3 for node MAP2K1_S222 and GSK3B\n", + "i_search = 4\n", + "Looking for paths with length: 4 for node MAP2K1_S222 and GSK3B\n", + "looking for paths in the network with length: 0 for node MAP2K1_S222 and AKT1\n", + "looking for paths in the network with length: 1 for node MAP2K1_S222 and AKT1\n", + "looking for paths in the network with length: 2 for node MAP2K1_S222 and AKT1\n", + "looking for paths in the network with length: 3 for node MAP2K1_S222 and AKT1\n", + "looking for paths in the network with length: 4 for node MAP2K1_S222 and AKT1\n", + "looking for paths in the network with length: 5 for node MAP2K1_S222 and AKT1\n", + "looking for paths in the network with length: 6 for node MAP2K1_S222 and AKT1\n", + "looking for paths in the network with length: 7 for node MAP2K1_S222 and AKT1\n", + "looking for paths in the network with length: 8 for node MAP2K1_S222 and AKT1\n", + "looking for paths in the network with length: 9 for node MAP2K1_S222 and AKT1\n", + "looking for paths in the network with length: 10 for node MAP2K1_S222 and AKT1\n", + "i_search = 4\n", + "Looking for paths with length: 0 for node MAP2K1_S222 and AKT1\n", + "i_search = 4\n", + "Looking for paths with length: 1 for node MAP2K1_S222 and AKT1\n", + "i_search = 4\n", + "Looking for paths with length: 2 for node MAP2K1_S222 and AKT1\n", + "i_search = 4\n", + "Looking for paths with length: 3 for node MAP2K1_S222 and AKT1\n", + "i_search = 4\n", + "Looking for paths with length: 4 for node MAP2K1_S222 and AKT1\n", + "looking for paths in the network with length: 0 for node MAP2K1_S222 and HSPB1\n", + "looking for paths in the network with length: 1 for node MAP2K1_S222 and HSPB1\n", + "looking for paths in the network with length: 2 for node MAP2K1_S222 and HSPB1\n", + "looking for paths in the network with length: 3 for node MAP2K1_S222 and HSPB1\n", + "looking for paths in the network with length: 4 for node MAP2K1_S222 and HSPB1\n", + "looking for paths in the network with length: 5 for node MAP2K1_S222 and HSPB1\n", + "looking for paths in the network with length: 6 for node MAP2K1_S222 and HSPB1\n", + "looking for paths in the network with length: 7 for node MAP2K1_S222 and HSPB1\n", + "looking for paths in the network with length: 8 for node MAP2K1_S222 and HSPB1\n", + "looking for paths in the network with length: 9 for node MAP2K1_S222 and HSPB1\n", + "looking for paths in the network with length: 10 for node MAP2K1_S222 and HSPB1\n", + "i_search = 4\n", + "Looking for paths with length: 0 for node MAP2K1_S222 and HSPB1\n", + "i_search = 4\n", + "Looking for paths with length: 1 for node MAP2K1_S222 and HSPB1\n", + "i_search = 4\n", + "Looking for paths with length: 2 for node MAP2K1_S222 and HSPB1\n", + "i_search = 4\n", + "Looking for paths with length: 3 for node MAP2K1_S222 and HSPB1\n", + "i_search = 4\n", + "Looking for paths with length: 4 for node MAP2K1_S222 and HSPB1\n", + "looking for paths in the network with length: 0 for node MAP2K1_S222 and MAPK14\n", + "looking for paths in the network with length: 1 for node MAP2K1_S222 and MAPK14\n", + "looking for paths in the network with length: 2 for node MAP2K1_S222 and MAPK14\n", + "looking for paths in the network with length: 3 for node MAP2K1_S222 and MAPK14\n", + "looking for paths in the network with length: 4 for node MAP2K1_S222 and MAPK14\n", + "looking for paths in the network with length: 5 for node MAP2K1_S222 and MAPK14\n", + "looking for paths in the network with length: 6 for node MAP2K1_S222 and MAPK14\n", + "looking for paths in the network with length: 7 for node MAP2K1_S222 and MAPK14\n", + "looking for paths in the network with length: 8 for node MAP2K1_S222 and MAPK14\n", + "looking for paths in the network with length: 9 for node MAP2K1_S222 and MAPK14\n", + "looking for paths in the network with length: 10 for node MAP2K1_S222 and MAPK14\n", + "i_search = 4\n", + "Looking for paths with length: 0 for node MAP2K1_S222 and MAPK14\n", + "i_search = 4\n", + "Looking for paths with length: 1 for node MAP2K1_S222 and MAPK14\n", + "i_search = 4\n", + "Looking for paths with length: 2 for node MAP2K1_S222 and MAPK14\n", + "i_search = 4\n", + "Looking for paths with length: 3 for node MAP2K1_S222 and MAPK14\n", + "i_search = 4\n", + "Looking for paths with length: 4 for node MAP2K1_S222 and MAPK14\n", + "looking for paths in the network with length: 0 for node MAP2K1_S222 and MAP2K1\n", + "looking for paths in the network with length: 1 for node MAP2K1_S222 and MAP2K1\n", + "looking for paths in the network with length: 2 for node MAP2K1_S222 and MAP2K1\n", + "looking for paths in the network with length: 3 for node MAP2K1_S222 and MAP2K1\n", + "looking for paths in the network with length: 4 for node MAP2K1_S222 and MAP2K1\n", + "looking for paths in the network with length: 5 for node MAP2K1_S222 and MAP2K1\n", + "looking for paths in the network with length: 6 for node MAP2K1_S222 and MAP2K1\n", + "looking for paths in the network with length: 7 for node MAP2K1_S222 and MAP2K1\n", + "looking for paths in the network with length: 8 for node MAP2K1_S222 and MAP2K1\n", + "looking for paths in the network with length: 9 for node MAP2K1_S222 and MAP2K1\n", + "looking for paths in the network with length: 10 for node MAP2K1_S222 and MAP2K1\n", + "i_search = 4\n", + "Looking for paths with length: 0 for node MAP2K1_S222 and MAP2K1\n", + "i_search = 4\n", + "Looking for paths with length: 1 for node MAP2K1_S222 and MAP2K1\n", + "i_search = 4\n", + "Looking for paths with length: 2 for node MAP2K1_S222 and MAP2K1\n", + "i_search = 4\n", + "Looking for paths with length: 3 for node MAP2K1_S222 and MAP2K1\n", + "i_search = 4\n", + "Looking for paths with length: 4 for node MAP2K1_S222 and MAP2K1\n", + "looking for paths in the network with length: 0 for node MAP2K1_S222 and RPS6KA1\n", + "looking for paths in the network with length: 1 for node MAP2K1_S222 and RPS6KA1\n", + "looking for paths in the network with length: 2 for node MAP2K1_S222 and RPS6KA1\n", + "looking for paths in the network with length: 3 for node MAP2K1_S222 and RPS6KA1\n", + "looking for paths in the network with length: 4 for node MAP2K1_S222 and RPS6KA1\n", + "looking for paths in the network with length: 5 for node MAP2K1_S222 and RPS6KA1\n", + "looking for paths in the network with length: 6 for node MAP2K1_S222 and RPS6KA1\n", + "looking for paths in the network with length: 7 for node MAP2K1_S222 and RPS6KA1\n", + "looking for paths in the network with length: 8 for node MAP2K1_S222 and RPS6KA1\n", + "looking for paths in the network with length: 9 for node MAP2K1_S222 and RPS6KA1\n", + "looking for paths in the network with length: 10 for node MAP2K1_S222 and RPS6KA1\n", + "i_search = 4\n", + "Looking for paths with length: 0 for node MAP2K1_S222 and RPS6KA1\n", + "i_search = 4\n", + "Looking for paths with length: 1 for node MAP2K1_S222 and RPS6KA1\n", + "i_search = 4\n", + "Looking for paths with length: 2 for node MAP2K1_S222 and RPS6KA1\n", + "i_search = 4\n", + "Looking for paths with length: 3 for node MAP2K1_S222 and RPS6KA1\n", + "i_search = 4\n", + "Looking for paths with length: 4 for node MAP2K1_S222 and RPS6KA1\n", + "looking for paths in the network with length: 0 for node MAP2K1_S222 and CREB1\n", + "looking for paths in the network with length: 1 for node MAP2K1_S222 and CREB1\n", + "looking for paths in the network with length: 2 for node MAP2K1_S222 and CREB1\n", + "looking for paths in the network with length: 3 for node MAP2K1_S222 and CREB1\n", + "looking for paths in the network with length: 4 for node MAP2K1_S222 and CREB1\n", + "looking for paths in the network with length: 5 for node MAP2K1_S222 and CREB1\n", + "looking for paths in the network with length: 6 for node MAP2K1_S222 and CREB1\n", + "looking for paths in the network with length: 7 for node MAP2K1_S222 and CREB1\n", + "looking for paths in the network with length: 8 for node MAP2K1_S222 and CREB1\n", + "looking for paths in the network with length: 9 for node MAP2K1_S222 and CREB1\n", + "looking for paths in the network with length: 10 for node MAP2K1_S222 and CREB1\n", + "i_search = 4\n", + "Looking for paths with length: 0 for node MAP2K1_S222 and CREB1\n", + "i_search = 4\n", + "Looking for paths with length: 1 for node MAP2K1_S222 and CREB1\n", + "i_search = 4\n", + "Looking for paths with length: 2 for node MAP2K1_S222 and CREB1\n", + "i_search = 4\n", + "Looking for paths with length: 3 for node MAP2K1_S222 and CREB1\n", + "i_search = 4\n", + "Looking for paths with length: 4 for node MAP2K1_S222 and CREB1\n", + "looking for paths in the network with length: 0 for node MAP2K1_S222 and NFKBIA\n", + "looking for paths in the network with length: 1 for node MAP2K1_S222 and NFKBIA\n", + "looking for paths in the network with length: 2 for node MAP2K1_S222 and NFKBIA\n", + "looking for paths in the network with length: 3 for node MAP2K1_S222 and NFKBIA\n", + "looking for paths in the network with length: 4 for node MAP2K1_S222 and NFKBIA\n", + "looking for paths in the network with length: 5 for node MAP2K1_S222 and NFKBIA\n", + "looking for paths in the network with length: 6 for node MAP2K1_S222 and NFKBIA\n", + "looking for paths in the network with length: 7 for node MAP2K1_S222 and NFKBIA\n", + "looking for paths in the network with length: 8 for node MAP2K1_S222 and NFKBIA\n", + "looking for paths in the network with length: 9 for node MAP2K1_S222 and NFKBIA\n", + "looking for paths in the network with length: 10 for node MAP2K1_S222 and NFKBIA\n", + "i_search = 4\n", + "Looking for paths with length: 0 for node MAP2K1_S222 and NFKBIA\n", + "i_search = 4\n", + "Looking for paths with length: 1 for node MAP2K1_S222 and NFKBIA\n", + "i_search = 4\n", + "Looking for paths with length: 2 for node MAP2K1_S222 and NFKBIA\n", + "i_search = 4\n", + "Looking for paths with length: 3 for node MAP2K1_S222 and NFKBIA\n", + "i_search = 4\n", + "Looking for paths with length: 4 for node MAP2K1_S222 and NFKBIA\n", + "looking for paths in the network with length: 0 for node MAP2K1_S222 and MTOR\n", + "looking for paths in the network with length: 1 for node MAP2K1_S222 and MTOR\n", + "looking for paths in the network with length: 2 for node MAP2K1_S222 and MTOR\n", + "looking for paths in the network with length: 3 for node MAP2K1_S222 and MTOR\n", + "looking for paths in the network with length: 4 for node MAP2K1_S222 and MTOR\n", + "looking for paths in the network with length: 5 for node MAP2K1_S222 and MTOR\n", + "looking for paths in the network with length: 6 for node MAP2K1_S222 and MTOR\n", + "looking for paths in the network with length: 7 for node MAP2K1_S222 and MTOR\n", + "looking for paths in the network with length: 8 for node MAP2K1_S222 and MTOR\n", + "looking for paths in the network with length: 9 for node MAP2K1_S222 and MTOR\n", + "looking for paths in the network with length: 10 for node MAP2K1_S222 and MTOR\n", + "i_search = 4\n", + "Looking for paths with length: 0 for node MAP2K1_S222 and MTOR\n", + "i_search = 4\n", + "Looking for paths with length: 1 for node MAP2K1_S222 and MTOR\n", + "i_search = 4\n", + "Looking for paths with length: 2 for node MAP2K1_S222 and MTOR\n", + "i_search = 4\n", + "Looking for paths with length: 3 for node MAP2K1_S222 and MTOR\n", + "i_search = 4\n", + "Looking for paths with length: 4 for node MAP2K1_S222 and MTOR\n", + "looking for paths in the network with length: 0 for node MAP2K1_S222 and JUN\n", + "looking for paths in the network with length: 1 for node MAP2K1_S222 and JUN\n", + "looking for paths in the network with length: 2 for node MAP2K1_S222 and JUN\n", + "looking for paths in the network with length: 3 for node MAP2K1_S222 and JUN\n", + "looking for paths in the network with length: 4 for node MAP2K1_S222 and JUN\n", + "looking for paths in the network with length: 5 for node MAP2K1_S222 and JUN\n", + "looking for paths in the network with length: 6 for node MAP2K1_S222 and JUN\n", + "looking for paths in the network with length: 7 for node MAP2K1_S222 and JUN\n", + "looking for paths in the network with length: 8 for node MAP2K1_S222 and JUN\n", + "looking for paths in the network with length: 9 for node MAP2K1_S222 and JUN\n", + "looking for paths in the network with length: 10 for node MAP2K1_S222 and JUN\n", + "i_search = 4\n", + "Looking for paths with length: 0 for node MAP2K1_S222 and JUN\n", + "i_search = 4\n", + "Looking for paths with length: 1 for node MAP2K1_S222 and JUN\n", + "i_search = 4\n", + "Looking for paths with length: 2 for node MAP2K1_S222 and JUN\n", + "i_search = 4\n", + "Looking for paths with length: 3 for node MAP2K1_S222 and JUN\n", + "i_search = 4\n", + "Looking for paths with length: 4 for node MAP2K1_S222 and JUN\n", + "looking for paths in the network with length: 0 for node MAP2K1_S222 and EGFR\n", + "looking for paths in the network with length: 1 for node MAP2K1_S222 and EGFR\n", + "looking for paths in the network with length: 2 for node MAP2K1_S222 and EGFR\n", + "looking for paths in the network with length: 3 for node MAP2K1_S222 and EGFR\n", + "looking for paths in the network with length: 4 for node MAP2K1_S222 and EGFR\n", + "looking for paths in the network with length: 5 for node MAP2K1_S222 and EGFR\n", + "looking for paths in the network with length: 6 for node MAP2K1_S222 and EGFR\n", + "looking for paths in the network with length: 7 for node MAP2K1_S222 and EGFR\n", + "looking for paths in the network with length: 8 for node MAP2K1_S222 and EGFR\n", + "looking for paths in the network with length: 9 for node MAP2K1_S222 and EGFR\n", + "looking for paths in the network with length: 10 for node MAP2K1_S222 and EGFR\n", + "i_search = 4\n", + "Looking for paths with length: 0 for node MAP2K1_S222 and EGFR\n", + "i_search = 4\n", + "Looking for paths with length: 1 for node MAP2K1_S222 and EGFR\n", + "i_search = 4\n", + "Looking for paths with length: 2 for node MAP2K1_S222 and EGFR\n", + "i_search = 4\n", + "Looking for paths with length: 3 for node MAP2K1_S222 and EGFR\n", + "i_search = 4\n", + "Looking for paths with length: 4 for node MAP2K1_S222 and EGFR\n", + "looking for paths in the network with length: 0 for node MAP2K1_S222 and MAPK3\n", + "looking for paths in the network with length: 1 for node MAP2K1_S222 and MAPK3\n", + "looking for paths in the network with length: 2 for node MAP2K1_S222 and MAPK3\n", + "looking for paths in the network with length: 3 for node MAP2K1_S222 and MAPK3\n", + "looking for paths in the network with length: 4 for node MAP2K1_S222 and MAPK3\n", + "looking for paths in the network with length: 5 for node MAP2K1_S222 and MAPK3\n", + "looking for paths in the network with length: 6 for node MAP2K1_S222 and MAPK3\n", + "looking for paths in the network with length: 7 for node MAP2K1_S222 and MAPK3\n", + "looking for paths in the network with length: 8 for node MAP2K1_S222 and MAPK3\n", + "looking for paths in the network with length: 9 for node MAP2K1_S222 and MAPK3\n", + "looking for paths in the network with length: 10 for node MAP2K1_S222 and MAPK3\n", + "i_search = 4\n", + "Looking for paths with length: 0 for node MAP2K1_S222 and MAPK3\n", + "i_search = 4\n", + "Looking for paths with length: 1 for node MAP2K1_S222 and MAPK3\n", + "i_search = 4\n", + "Looking for paths with length: 2 for node MAP2K1_S222 and MAPK3\n", + "i_search = 4\n", + "Looking for paths with length: 3 for node MAP2K1_S222 and MAPK3\n", + "i_search = 4\n", + "Looking for paths with length: 4 for node MAP2K1_S222 and MAPK3\n", + "looking for paths in the network with length: 0 for node MAP2K1_S222 and PTPN11\n", + "looking for paths in the network with length: 1 for node MAP2K1_S222 and PTPN11\n", + "looking for paths in the network with length: 2 for node MAP2K1_S222 and PTPN11\n", + "looking for paths in the network with length: 3 for node MAP2K1_S222 and PTPN11\n", + "looking for paths in the network with length: 4 for node MAP2K1_S222 and PTPN11\n", + "looking for paths in the network with length: 5 for node MAP2K1_S222 and PTPN11\n", + "looking for paths in the network with length: 6 for node MAP2K1_S222 and PTPN11\n", + "looking for paths in the network with length: 7 for node MAP2K1_S222 and PTPN11\n", + "looking for paths in the network with length: 8 for node MAP2K1_S222 and PTPN11\n", + "looking for paths in the network with length: 9 for node MAP2K1_S222 and PTPN11\n", + "looking for paths in the network with length: 10 for node MAP2K1_S222 and PTPN11\n", + "i_search = 4\n", + "Looking for paths with length: 0 for node MAP2K1_S222 and PTPN11\n", + "i_search = 4\n", + "Looking for paths with length: 1 for node MAP2K1_S222 and PTPN11\n", + "i_search = 4\n", + "Looking for paths with length: 2 for node MAP2K1_S222 and PTPN11\n", + "i_search = 4\n", + "Looking for paths with length: 3 for node MAP2K1_S222 and PTPN11\n", + "i_search = 4\n", + "Looking for paths with length: 4 for node MAP2K1_S222 and PTPN11\n", + "looking for paths in the network with length: 0 for node MAP2K1_S222 and STAT3\n", + "looking for paths in the network with length: 1 for node MAP2K1_S222 and STAT3\n", + "looking for paths in the network with length: 2 for node MAP2K1_S222 and STAT3\n", + "looking for paths in the network with length: 3 for node MAP2K1_S222 and STAT3\n", + "looking for paths in the network with length: 4 for node MAP2K1_S222 and STAT3\n", + "looking for paths in the network with length: 5 for node MAP2K1_S222 and STAT3\n", + "looking for paths in the network with length: 6 for node MAP2K1_S222 and STAT3\n", + "looking for paths in the network with length: 7 for node MAP2K1_S222 and STAT3\n", + "looking for paths in the network with length: 8 for node MAP2K1_S222 and STAT3\n", + "looking for paths in the network with length: 9 for node MAP2K1_S222 and STAT3\n", + "looking for paths in the network with length: 10 for node MAP2K1_S222 and STAT3\n", + "i_search = 4\n", + "Looking for paths with length: 0 for node MAP2K1_S222 and STAT3\n", + "i_search = 4\n", + "Looking for paths with length: 1 for node MAP2K1_S222 and STAT3\n", + "i_search = 4\n", + "Looking for paths with length: 2 for node MAP2K1_S222 and STAT3\n", + "i_search = 4\n", + "Looking for paths with length: 3 for node MAP2K1_S222 and STAT3\n", + "i_search = 4\n", + "Looking for paths with length: 4 for node MAP2K1_S222 and STAT3\n", + "looking for paths in the network with length: 0 for node MAP2K1_S222 and CHEK2\n", + "looking for paths in the network with length: 1 for node MAP2K1_S222 and CHEK2\n", + "looking for paths in the network with length: 2 for node MAP2K1_S222 and CHEK2\n", + "looking for paths in the network with length: 3 for node MAP2K1_S222 and CHEK2\n", + "looking for paths in the network with length: 4 for node MAP2K1_S222 and CHEK2\n", + "looking for paths in the network with length: 5 for node MAP2K1_S222 and CHEK2\n", + "looking for paths in the network with length: 6 for node MAP2K1_S222 and CHEK2\n", + "looking for paths in the network with length: 7 for node MAP2K1_S222 and CHEK2\n", + "looking for paths in the network with length: 8 for node MAP2K1_S222 and CHEK2\n", + "looking for paths in the network with length: 9 for node MAP2K1_S222 and CHEK2\n", + "looking for paths in the network with length: 10 for node MAP2K1_S222 and CHEK2\n", + "i_search = 4\n", + "Looking for paths with length: 0 for node MAP2K1_S222 and CHEK2\n", + "i_search = 4\n", + "Looking for paths with length: 1 for node MAP2K1_S222 and CHEK2\n", + "i_search = 4\n", + "Looking for paths with length: 2 for node MAP2K1_S222 and CHEK2\n", + "i_search = 4\n", + "Looking for paths with length: 3 for node MAP2K1_S222 and CHEK2\n", + "i_search = 4\n", + "Looking for paths with length: 4 for node MAP2K1_S222 and CHEK2\n", + "looking for paths in the network with length: 0 for node MAP2K1_S222 and RELA\n", + "looking for paths in the network with length: 1 for node MAP2K1_S222 and RELA\n", + "looking for paths in the network with length: 2 for node MAP2K1_S222 and RELA\n", + "looking for paths in the network with length: 3 for node MAP2K1_S222 and RELA\n", + "looking for paths in the network with length: 4 for node MAP2K1_S222 and RELA\n", + "looking for paths in the network with length: 5 for node MAP2K1_S222 and RELA\n", + "looking for paths in the network with length: 6 for node MAP2K1_S222 and RELA\n", + "looking for paths in the network with length: 7 for node MAP2K1_S222 and RELA\n", + "looking for paths in the network with length: 8 for node MAP2K1_S222 and RELA\n", + "looking for paths in the network with length: 9 for node MAP2K1_S222 and RELA\n", + "looking for paths in the network with length: 10 for node MAP2K1_S222 and RELA\n", + "i_search = 4\n", + "Looking for paths with length: 0 for node MAP2K1_S222 and RELA\n", + "i_search = 4\n", + "Looking for paths with length: 1 for node MAP2K1_S222 and RELA\n", + "i_search = 4\n", + "Looking for paths with length: 2 for node MAP2K1_S222 and RELA\n", + "i_search = 4\n", + "Looking for paths with length: 3 for node MAP2K1_S222 and RELA\n", + "i_search = 4\n", + "Looking for paths with length: 4 for node MAP2K1_S222 and RELA\n", + "looking for paths in the network with length: 0 for node MAP2K1_S222 and MARCKS\n", + "looking for paths in the network with length: 1 for node MAP2K1_S222 and MARCKS\n", + "looking for paths in the network with length: 2 for node MAP2K1_S222 and MARCKS\n", + "looking for paths in the network with length: 3 for node MAP2K1_S222 and MARCKS\n", + "looking for paths in the network with length: 4 for node MAP2K1_S222 and MARCKS\n", + "looking for paths in the network with length: 5 for node MAP2K1_S222 and MARCKS\n", + "looking for paths in the network with length: 6 for node MAP2K1_S222 and MARCKS\n", + "looking for paths in the network with length: 7 for node MAP2K1_S222 and MARCKS\n", + "looking for paths in the network with length: 8 for node MAP2K1_S222 and MARCKS\n", + "looking for paths in the network with length: 9 for node MAP2K1_S222 and MARCKS\n", + "looking for paths in the network with length: 10 for node MAP2K1_S222 and MARCKS\n", + "i_search = 4\n", + "Looking for paths with length: 0 for node MAP2K1_S222 and MARCKS\n", + "i_search = 4\n", + "Looking for paths with length: 1 for node MAP2K1_S222 and MARCKS\n", + "i_search = 4\n", + "Looking for paths with length: 2 for node MAP2K1_S222 and MARCKS\n", + "i_search = 4\n", + "Looking for paths with length: 3 for node MAP2K1_S222 and MARCKS\n", + "i_search = 4\n", + "Looking for paths with length: 4 for node MAP2K1_S222 and MARCKS\n", + "looking for paths in the network with length: 0 for node RPS6KA1_S380 and CREB1_S133\n", + "looking for paths in the network with length: 1 for node RPS6KA1_S380 and CREB1_S133\n", + "looking for paths in the network with length: 2 for node RPS6KA1_S380 and CREB1_S133\n", + "looking for paths in the network with length: 3 for node RPS6KA1_S380 and CREB1_S133\n", + "looking for paths in the network with length: 4 for node RPS6KA1_S380 and CREB1_S133\n", + "looking for paths in the network with length: 5 for node RPS6KA1_S380 and CREB1_S133\n", + "looking for paths in the network with length: 6 for node RPS6KA1_S380 and CREB1_S133\n", + "looking for paths in the network with length: 7 for node RPS6KA1_S380 and CREB1_S133\n", + "looking for paths in the network with length: 8 for node RPS6KA1_S380 and CREB1_S133\n", + "looking for paths in the network with length: 9 for node RPS6KA1_S380 and CREB1_S133\n", + "looking for paths in the network with length: 10 for node RPS6KA1_S380 and CREB1_S133\n", + "i_search = 4\n", + "Looking for paths with length: 0 for node RPS6KA1_S380 and CREB1_S133\n", + "i_search = 4\n", + "Looking for paths with length: 1 for node RPS6KA1_S380 and CREB1_S133\n", + "i_search = 4\n", + "Looking for paths with length: 2 for node RPS6KA1_S380 and CREB1_S133\n", + "i_search = 4\n", + "Looking for paths with length: 3 for node RPS6KA1_S380 and CREB1_S133\n", + "i_search = 4\n", + "Looking for paths with length: 4 for node RPS6KA1_S380 and CREB1_S133\n", + "looking for paths in the network with length: 0 for node RPS6KA1_S380 and NFKBIA_S32\n", + "looking for paths in the network with length: 1 for node RPS6KA1_S380 and NFKBIA_S32\n", + "looking for paths in the network with length: 2 for node RPS6KA1_S380 and NFKBIA_S32\n", + "looking for paths in the network with length: 3 for node RPS6KA1_S380 and NFKBIA_S32\n", + "looking for paths in the network with length: 4 for node RPS6KA1_S380 and NFKBIA_S32\n", + "looking for paths in the network with length: 5 for node RPS6KA1_S380 and NFKBIA_S32\n", + "looking for paths in the network with length: 6 for node RPS6KA1_S380 and NFKBIA_S32\n", + "looking for paths in the network with length: 7 for node RPS6KA1_S380 and NFKBIA_S32\n", + "looking for paths in the network with length: 8 for node RPS6KA1_S380 and NFKBIA_S32\n", + "looking for paths in the network with length: 9 for node RPS6KA1_S380 and NFKBIA_S32\n", + "looking for paths in the network with length: 10 for node RPS6KA1_S380 and NFKBIA_S32\n", + "i_search = 4\n", + "Looking for paths with length: 0 for node RPS6KA1_S380 and NFKBIA_S32\n", + "i_search = 4\n", + "Looking for paths with length: 1 for node RPS6KA1_S380 and NFKBIA_S32\n", + "i_search = 4\n", + "Looking for paths with length: 2 for node RPS6KA1_S380 and NFKBIA_S32\n", + "[['RPS6KA1_S380', 'RPS6KA1', 'NFKBIA_S32']]\n", + "RPS6KA1_S380 RPS6KA1\n", + "RPS6KA1 NFKBIA_S32\n", + "looking for paths in the network with length: 0 for node RPS6KA1_S380 and NFKBIA_S36\n", + "looking for paths in the network with length: 1 for node RPS6KA1_S380 and NFKBIA_S36\n", + "looking for paths in the network with length: 2 for node RPS6KA1_S380 and NFKBIA_S36\n", + "looking for paths in the network with length: 3 for node RPS6KA1_S380 and NFKBIA_S36\n", + "looking for paths in the network with length: 4 for node RPS6KA1_S380 and NFKBIA_S36\n", + "looking for paths in the network with length: 5 for node RPS6KA1_S380 and NFKBIA_S36\n", + "looking for paths in the network with length: 6 for node RPS6KA1_S380 and NFKBIA_S36\n", + "looking for paths in the network with length: 7 for node RPS6KA1_S380 and NFKBIA_S36\n", + "looking for paths in the network with length: 8 for node RPS6KA1_S380 and NFKBIA_S36\n", + "looking for paths in the network with length: 9 for node RPS6KA1_S380 and NFKBIA_S36\n", + "looking for paths in the network with length: 10 for node RPS6KA1_S380 and NFKBIA_S36\n", + "i_search = 4\n", + "Looking for paths with length: 0 for node RPS6KA1_S380 and NFKBIA_S36\n", + "i_search = 4\n", + "Looking for paths with length: 1 for node RPS6KA1_S380 and NFKBIA_S36\n", + "i_search = 4\n", + "Looking for paths with length: 2 for node RPS6KA1_S380 and NFKBIA_S36\n", + "i_search = 4\n", + "Looking for paths with length: 3 for node RPS6KA1_S380 and NFKBIA_S36\n", + "i_search = 4\n", + "Looking for paths with length: 4 for node RPS6KA1_S380 and NFKBIA_S36\n", + "looking for paths in the network with length: 0 for node RPS6KA1_S380 and MTOR_S2448\n", + "looking for paths in the network with length: 1 for node RPS6KA1_S380 and MTOR_S2448\n", + "looking for paths in the network with length: 2 for node RPS6KA1_S380 and MTOR_S2448\n", + "looking for paths in the network with length: 3 for node RPS6KA1_S380 and MTOR_S2448\n", + "looking for paths in the network with length: 4 for node RPS6KA1_S380 and MTOR_S2448\n", + "looking for paths in the network with length: 5 for node RPS6KA1_S380 and MTOR_S2448\n", + "looking for paths in the network with length: 6 for node RPS6KA1_S380 and MTOR_S2448\n", + "looking for paths in the network with length: 7 for node RPS6KA1_S380 and MTOR_S2448\n", + "looking for paths in the network with length: 8 for node RPS6KA1_S380 and MTOR_S2448\n", + "looking for paths in the network with length: 9 for node RPS6KA1_S380 and MTOR_S2448\n", + "looking for paths in the network with length: 10 for node RPS6KA1_S380 and MTOR_S2448\n", + "i_search = 4\n", + "Looking for paths with length: 0 for node RPS6KA1_S380 and MTOR_S2448\n", + "i_search = 4\n", + "Looking for paths with length: 1 for node RPS6KA1_S380 and MTOR_S2448\n", + "i_search = 4\n", + "Looking for paths with length: 2 for node RPS6KA1_S380 and MTOR_S2448\n", + "i_search = 4\n", + "Looking for paths with length: 3 for node RPS6KA1_S380 and MTOR_S2448\n", + "i_search = 4\n", + "Looking for paths with length: 4 for node RPS6KA1_S380 and MTOR_S2448\n", + "looking for paths in the network with length: 0 for node RPS6KA1_S380 and JUN_S63\n", + "looking for paths in the network with length: 1 for node RPS6KA1_S380 and JUN_S63\n", + "looking for paths in the network with length: 2 for node RPS6KA1_S380 and JUN_S63\n", + "looking for paths in the network with length: 3 for node RPS6KA1_S380 and JUN_S63\n", + "looking for paths in the network with length: 4 for node RPS6KA1_S380 and JUN_S63\n", + "looking for paths in the network with length: 5 for node RPS6KA1_S380 and JUN_S63\n", + "looking for paths in the network with length: 6 for node RPS6KA1_S380 and JUN_S63\n", + "looking for paths in the network with length: 7 for node RPS6KA1_S380 and JUN_S63\n", + "looking for paths in the network with length: 8 for node RPS6KA1_S380 and JUN_S63\n", + "looking for paths in the network with length: 9 for node RPS6KA1_S380 and JUN_S63\n", + "looking for paths in the network with length: 10 for node RPS6KA1_S380 and JUN_S63\n", + "i_search = 4\n", + "Looking for paths with length: 0 for node RPS6KA1_S380 and JUN_S63\n", + "i_search = 4\n", + "Looking for paths with length: 1 for node RPS6KA1_S380 and JUN_S63\n", + "i_search = 4\n", + "Looking for paths with length: 2 for node RPS6KA1_S380 and JUN_S63\n", + "i_search = 4\n", + "Looking for paths with length: 3 for node RPS6KA1_S380 and JUN_S63\n", + "i_search = 4\n", + "Looking for paths with length: 4 for node RPS6KA1_S380 and JUN_S63\n", + "looking for paths in the network with length: 0 for node RPS6KA1_S380 and EGFR_Y1068\n", + "looking for paths in the network with length: 1 for node RPS6KA1_S380 and EGFR_Y1068\n", + "looking for paths in the network with length: 2 for node RPS6KA1_S380 and EGFR_Y1068\n", + "looking for paths in the network with length: 3 for node RPS6KA1_S380 and EGFR_Y1068\n", + "looking for paths in the network with length: 4 for node RPS6KA1_S380 and EGFR_Y1068\n", + "looking for paths in the network with length: 5 for node RPS6KA1_S380 and EGFR_Y1068\n", + "looking for paths in the network with length: 6 for node RPS6KA1_S380 and EGFR_Y1068\n", + "looking for paths in the network with length: 7 for node RPS6KA1_S380 and EGFR_Y1068\n", + "looking for paths in the network with length: 8 for node RPS6KA1_S380 and EGFR_Y1068\n", + "looking for paths in the network with length: 9 for node RPS6KA1_S380 and EGFR_Y1068\n", + "looking for paths in the network with length: 10 for node RPS6KA1_S380 and EGFR_Y1068\n", + "i_search = 4\n", + "Looking for paths with length: 0 for node RPS6KA1_S380 and EGFR_Y1068\n", + "i_search = 4\n", + "Looking for paths with length: 1 for node RPS6KA1_S380 and EGFR_Y1068\n", + "i_search = 4\n", + "Looking for paths with length: 2 for node RPS6KA1_S380 and EGFR_Y1068\n", + "i_search = 4\n", + "Looking for paths with length: 3 for node RPS6KA1_S380 and EGFR_Y1068\n", + "i_search = 4\n", + "Looking for paths with length: 4 for node RPS6KA1_S380 and EGFR_Y1068\n", + "looking for paths in the network with length: 0 for node RPS6KA1_S380 and MAPK3_T202\n", + "looking for paths in the network with length: 1 for node RPS6KA1_S380 and MAPK3_T202\n", + "looking for paths in the network with length: 2 for node RPS6KA1_S380 and MAPK3_T202\n", + "Found a path!\n", + "[['RPS6KA1_S380', 'MAPK3', 'MAPK3_T202']]\n", + "looking for paths in the network with length: 0 for node RPS6KA1_S380 and MAPK3_Y204\n", + "looking for paths in the network with length: 1 for node RPS6KA1_S380 and MAPK3_Y204\n", + "looking for paths in the network with length: 2 for node RPS6KA1_S380 and MAPK3_Y204\n", + "Found a path!\n", + "[['RPS6KA1_S380', 'MAPK3', 'MAPK3_Y204']]\n", + "looking for paths in the network with length: 0 for node RPS6KA1_S380 and PTPN11_Y542\n", + "looking for paths in the network with length: 1 for node RPS6KA1_S380 and PTPN11_Y542\n", + "looking for paths in the network with length: 2 for node RPS6KA1_S380 and PTPN11_Y542\n", + "looking for paths in the network with length: 3 for node RPS6KA1_S380 and PTPN11_Y542\n", + "looking for paths in the network with length: 4 for node RPS6KA1_S380 and PTPN11_Y542\n", + "looking for paths in the network with length: 5 for node RPS6KA1_S380 and PTPN11_Y542\n", + "looking for paths in the network with length: 6 for node RPS6KA1_S380 and PTPN11_Y542\n", + "looking for paths in the network with length: 7 for node RPS6KA1_S380 and PTPN11_Y542\n", + "looking for paths in the network with length: 8 for node RPS6KA1_S380 and PTPN11_Y542\n", + "looking for paths in the network with length: 9 for node RPS6KA1_S380 and PTPN11_Y542\n", + "looking for paths in the network with length: 10 for node RPS6KA1_S380 and PTPN11_Y542\n", + "i_search = 4\n", + "Looking for paths with length: 0 for node RPS6KA1_S380 and PTPN11_Y542\n", + "i_search = 4\n", + "Looking for paths with length: 1 for node RPS6KA1_S380 and PTPN11_Y542\n", + "i_search = 4\n", + "Looking for paths with length: 2 for node RPS6KA1_S380 and PTPN11_Y542\n", + "i_search = 4\n", + "Looking for paths with length: 3 for node RPS6KA1_S380 and PTPN11_Y542\n", + "i_search = 4\n", + "Looking for paths with length: 4 for node RPS6KA1_S380 and PTPN11_Y542\n", + "looking for paths in the network with length: 0 for node RPS6KA1_S380 and STAT3_Y705\n", + "looking for paths in the network with length: 1 for node RPS6KA1_S380 and STAT3_Y705\n", + "looking for paths in the network with length: 2 for node RPS6KA1_S380 and STAT3_Y705\n", + "looking for paths in the network with length: 3 for node RPS6KA1_S380 and STAT3_Y705\n", + "looking for paths in the network with length: 4 for node RPS6KA1_S380 and STAT3_Y705\n", + "looking for paths in the network with length: 5 for node RPS6KA1_S380 and STAT3_Y705\n", + "looking for paths in the network with length: 6 for node RPS6KA1_S380 and STAT3_Y705\n", + "Found a path!\n", + "[['RPS6KA1_S380', 'RPS6KA1', 'GSK3B_S9', 'GSK3B', 'SRC_S493', 'SRC', 'STAT3_Y705'], ['RPS6KA1_S380', 'RPS6KA1', 'GSK3B_S9', 'GSK3B', 'SRC_S51', 'SRC', 'STAT3_Y705'], ['RPS6KA1_S380', 'RPS6KA1', 'GSK3B_S9', 'GSK3B', 'SRC_S43', 'SRC', 'STAT3_Y705'], ['RPS6KA1_S380', 'RPS6KA1', 'GSK3B_S9', 'GSK3B', 'SRC_Y419', 'SRC', 'STAT3_Y705']]\n", + "looking for paths in the network with length: 0 for node RPS6KA1_S380 and CHEK2_T68\n", + "looking for paths in the network with length: 1 for node RPS6KA1_S380 and CHEK2_T68\n", + "looking for paths in the network with length: 2 for node RPS6KA1_S380 and CHEK2_T68\n", + "looking for paths in the network with length: 3 for node RPS6KA1_S380 and CHEK2_T68\n", + "looking for paths in the network with length: 4 for node RPS6KA1_S380 and CHEK2_T68\n", + "looking for paths in the network with length: 5 for node RPS6KA1_S380 and CHEK2_T68\n", + "looking for paths in the network with length: 6 for node RPS6KA1_S380 and CHEK2_T68\n", + "looking for paths in the network with length: 7 for node RPS6KA1_S380 and CHEK2_T68\n", + "looking for paths in the network with length: 8 for node RPS6KA1_S380 and CHEK2_T68\n", + "looking for paths in the network with length: 9 for node RPS6KA1_S380 and CHEK2_T68\n", + "looking for paths in the network with length: 10 for node RPS6KA1_S380 and CHEK2_T68\n", + "i_search = 4\n", + "Looking for paths with length: 0 for node RPS6KA1_S380 and CHEK2_T68\n", + "i_search = 4\n", + "Looking for paths with length: 1 for node RPS6KA1_S380 and CHEK2_T68\n", + "i_search = 4\n", + "Looking for paths with length: 2 for node RPS6KA1_S380 and CHEK2_T68\n", + "i_search = 4\n", + "Looking for paths with length: 3 for node RPS6KA1_S380 and CHEK2_T68\n", + "i_search = 4\n", + "Looking for paths with length: 4 for node RPS6KA1_S380 and CHEK2_T68\n", + "looking for paths in the network with length: 0 for node RPS6KA1_S380 and RELA_S536\n", + "looking for paths in the network with length: 1 for node RPS6KA1_S380 and RELA_S536\n", + "looking for paths in the network with length: 2 for node RPS6KA1_S380 and RELA_S536\n", + "looking for paths in the network with length: 3 for node RPS6KA1_S380 and RELA_S536\n", + "looking for paths in the network with length: 4 for node RPS6KA1_S380 and RELA_S536\n", + "looking for paths in the network with length: 5 for node RPS6KA1_S380 and RELA_S536\n", + "looking for paths in the network with length: 6 for node RPS6KA1_S380 and RELA_S536\n", + "Found a path!\n", + "[['RPS6KA1_S380', 'RPS6KA1', 'GSK3B_S9', 'GSK3B', 'TBK1_S172', 'TBK1', 'RELA_S536']]\n", + "looking for paths in the network with length: 0 for node RPS6KA1_S380 and MARCKS_S170\n", + "looking for paths in the network with length: 1 for node RPS6KA1_S380 and MARCKS_S170\n", + "looking for paths in the network with length: 2 for node RPS6KA1_S380 and MARCKS_S170\n", + "looking for paths in the network with length: 3 for node RPS6KA1_S380 and MARCKS_S170\n", + "looking for paths in the network with length: 4 for node RPS6KA1_S380 and MARCKS_S170\n", + "looking for paths in the network with length: 5 for node RPS6KA1_S380 and MARCKS_S170\n", + "looking for paths in the network with length: 6 for node RPS6KA1_S380 and MARCKS_S170\n", + "looking for paths in the network with length: 7 for node RPS6KA1_S380 and MARCKS_S170\n", + "looking for paths in the network with length: 8 for node RPS6KA1_S380 and MARCKS_S170\n", + "looking for paths in the network with length: 9 for node RPS6KA1_S380 and MARCKS_S170\n", + "looking for paths in the network with length: 10 for node RPS6KA1_S380 and MARCKS_S170\n", + "i_search = 4\n", + "Looking for paths with length: 0 for node RPS6KA1_S380 and MARCKS_S170\n", + "i_search = 4\n", + "Looking for paths with length: 1 for node RPS6KA1_S380 and MARCKS_S170\n", + "i_search = 4\n", + "Looking for paths with length: 2 for node RPS6KA1_S380 and MARCKS_S170\n", + "i_search = 4\n", + "Looking for paths with length: 3 for node RPS6KA1_S380 and MARCKS_S170\n", + "i_search = 4\n", + "Looking for paths with length: 4 for node RPS6KA1_S380 and MARCKS_S170\n", + "looking for paths in the network with length: 0 for node RPS6KA1_S380 and SMAD3\n", + "looking for paths in the network with length: 1 for node RPS6KA1_S380 and SMAD3\n", + "looking for paths in the network with length: 2 for node RPS6KA1_S380 and SMAD3\n", + "looking for paths in the network with length: 3 for node RPS6KA1_S380 and SMAD3\n", + "looking for paths in the network with length: 4 for node RPS6KA1_S380 and SMAD3\n", + "looking for paths in the network with length: 5 for node RPS6KA1_S380 and SMAD3\n", + "looking for paths in the network with length: 6 for node RPS6KA1_S380 and SMAD3\n", + "looking for paths in the network with length: 7 for node RPS6KA1_S380 and SMAD3\n", + "looking for paths in the network with length: 8 for node RPS6KA1_S380 and SMAD3\n", + "looking for paths in the network with length: 9 for node RPS6KA1_S380 and SMAD3\n", + "looking for paths in the network with length: 10 for node RPS6KA1_S380 and SMAD3\n", + "i_search = 4\n", + "Looking for paths with length: 0 for node RPS6KA1_S380 and SMAD3\n", + "i_search = 4\n", + "Looking for paths with length: 1 for node RPS6KA1_S380 and SMAD3\n", + "i_search = 4\n", + "Looking for paths with length: 2 for node RPS6KA1_S380 and SMAD3\n", + "i_search = 4\n", + "Looking for paths with length: 3 for node RPS6KA1_S380 and SMAD3\n", + "i_search = 4\n", + "Looking for paths with length: 4 for node RPS6KA1_S380 and SMAD3\n", + "looking for paths in the network with length: 0 for node RPS6KA1_S380 and TP53\n", + "looking for paths in the network with length: 1 for node RPS6KA1_S380 and TP53\n", + "looking for paths in the network with length: 2 for node RPS6KA1_S380 and TP53\n", + "looking for paths in the network with length: 3 for node RPS6KA1_S380 and TP53\n", + "looking for paths in the network with length: 4 for node RPS6KA1_S380 and TP53\n", + "looking for paths in the network with length: 5 for node RPS6KA1_S380 and TP53\n", + "looking for paths in the network with length: 6 for node RPS6KA1_S380 and TP53\n", + "looking for paths in the network with length: 7 for node RPS6KA1_S380 and TP53\n", + "looking for paths in the network with length: 8 for node RPS6KA1_S380 and TP53\n", + "looking for paths in the network with length: 9 for node RPS6KA1_S380 and TP53\n", + "looking for paths in the network with length: 10 for node RPS6KA1_S380 and TP53\n", + "i_search = 4\n", + "Looking for paths with length: 0 for node RPS6KA1_S380 and TP53\n", + "i_search = 4\n", + "Looking for paths with length: 1 for node RPS6KA1_S380 and TP53\n", + "i_search = 4\n", + "Looking for paths with length: 2 for node RPS6KA1_S380 and TP53\n", + "i_search = 4\n", + "Looking for paths with length: 3 for node RPS6KA1_S380 and TP53\n", + "i_search = 4\n", + "Looking for paths with length: 4 for node RPS6KA1_S380 and TP53\n", + "looking for paths in the network with length: 0 for node RPS6KA1_S380 and AKT1S1\n", + "looking for paths in the network with length: 1 for node RPS6KA1_S380 and AKT1S1\n", + "looking for paths in the network with length: 2 for node RPS6KA1_S380 and AKT1S1\n", + "looking for paths in the network with length: 3 for node RPS6KA1_S380 and AKT1S1\n", + "looking for paths in the network with length: 4 for node RPS6KA1_S380 and AKT1S1\n", + "looking for paths in the network with length: 5 for node RPS6KA1_S380 and AKT1S1\n", + "looking for paths in the network with length: 6 for node RPS6KA1_S380 and AKT1S1\n", + "looking for paths in the network with length: 7 for node RPS6KA1_S380 and AKT1S1\n", + "looking for paths in the network with length: 8 for node RPS6KA1_S380 and AKT1S1\n", + "looking for paths in the network with length: 9 for node RPS6KA1_S380 and AKT1S1\n", + "looking for paths in the network with length: 10 for node RPS6KA1_S380 and AKT1S1\n", + "i_search = 4\n", + "Looking for paths with length: 0 for node RPS6KA1_S380 and AKT1S1\n", + "i_search = 4\n", + "Looking for paths with length: 1 for node RPS6KA1_S380 and AKT1S1\n", + "i_search = 4\n", + "Looking for paths with length: 2 for node RPS6KA1_S380 and AKT1S1\n", + "i_search = 4\n", + "Looking for paths with length: 3 for node RPS6KA1_S380 and AKT1S1\n", + "i_search = 4\n", + "Looking for paths with length: 4 for node RPS6KA1_S380 and AKT1S1\n", + "looking for paths in the network with length: 0 for node RPS6KA1_S380 and GSK3B\n", + "looking for paths in the network with length: 1 for node RPS6KA1_S380 and GSK3B\n", + "looking for paths in the network with length: 2 for node RPS6KA1_S380 and GSK3B\n", + "looking for paths in the network with length: 3 for node RPS6KA1_S380 and GSK3B\n", + "looking for paths in the network with length: 4 for node RPS6KA1_S380 and GSK3B\n", + "looking for paths in the network with length: 5 for node RPS6KA1_S380 and GSK3B\n", + "looking for paths in the network with length: 6 for node RPS6KA1_S380 and GSK3B\n", + "looking for paths in the network with length: 7 for node RPS6KA1_S380 and GSK3B\n", + "looking for paths in the network with length: 8 for node RPS6KA1_S380 and GSK3B\n", + "looking for paths in the network with length: 9 for node RPS6KA1_S380 and GSK3B\n", + "looking for paths in the network with length: 10 for node RPS6KA1_S380 and GSK3B\n", + "i_search = 4\n", + "Looking for paths with length: 0 for node RPS6KA1_S380 and GSK3B\n", + "i_search = 4\n", + "Looking for paths with length: 1 for node RPS6KA1_S380 and GSK3B\n", + "i_search = 4\n", + "Looking for paths with length: 2 for node RPS6KA1_S380 and GSK3B\n", + "i_search = 4\n", + "Looking for paths with length: 3 for node RPS6KA1_S380 and GSK3B\n", + "i_search = 4\n", + "Looking for paths with length: 4 for node RPS6KA1_S380 and GSK3B\n", + "looking for paths in the network with length: 0 for node RPS6KA1_S380 and AKT1\n", + "looking for paths in the network with length: 1 for node RPS6KA1_S380 and AKT1\n", + "looking for paths in the network with length: 2 for node RPS6KA1_S380 and AKT1\n", + "looking for paths in the network with length: 3 for node RPS6KA1_S380 and AKT1\n", + "looking for paths in the network with length: 4 for node RPS6KA1_S380 and AKT1\n", + "looking for paths in the network with length: 5 for node RPS6KA1_S380 and AKT1\n", + "looking for paths in the network with length: 6 for node RPS6KA1_S380 and AKT1\n", + "looking for paths in the network with length: 7 for node RPS6KA1_S380 and AKT1\n", + "looking for paths in the network with length: 8 for node RPS6KA1_S380 and AKT1\n", + "looking for paths in the network with length: 9 for node RPS6KA1_S380 and AKT1\n", + "looking for paths in the network with length: 10 for node RPS6KA1_S380 and AKT1\n", + "i_search = 4\n", + "Looking for paths with length: 0 for node RPS6KA1_S380 and AKT1\n", + "i_search = 4\n", + "Looking for paths with length: 1 for node RPS6KA1_S380 and AKT1\n", + "i_search = 4\n", + "Looking for paths with length: 2 for node RPS6KA1_S380 and AKT1\n", + "i_search = 4\n", + "Looking for paths with length: 3 for node RPS6KA1_S380 and AKT1\n", + "i_search = 4\n", + "Looking for paths with length: 4 for node RPS6KA1_S380 and AKT1\n", + "looking for paths in the network with length: 0 for node RPS6KA1_S380 and HSPB1\n", + "looking for paths in the network with length: 1 for node RPS6KA1_S380 and HSPB1\n", + "looking for paths in the network with length: 2 for node RPS6KA1_S380 and HSPB1\n", + "looking for paths in the network with length: 3 for node RPS6KA1_S380 and HSPB1\n", + "looking for paths in the network with length: 4 for node RPS6KA1_S380 and HSPB1\n", + "looking for paths in the network with length: 5 for node RPS6KA1_S380 and HSPB1\n", + "looking for paths in the network with length: 6 for node RPS6KA1_S380 and HSPB1\n", + "looking for paths in the network with length: 7 for node RPS6KA1_S380 and HSPB1\n", + "looking for paths in the network with length: 8 for node RPS6KA1_S380 and HSPB1\n", + "looking for paths in the network with length: 9 for node RPS6KA1_S380 and HSPB1\n", + "looking for paths in the network with length: 10 for node RPS6KA1_S380 and HSPB1\n", + "i_search = 4\n", + "Looking for paths with length: 0 for node RPS6KA1_S380 and HSPB1\n", + "i_search = 4\n", + "Looking for paths with length: 1 for node RPS6KA1_S380 and HSPB1\n", + "i_search = 4\n", + "Looking for paths with length: 2 for node RPS6KA1_S380 and HSPB1\n", + "i_search = 4\n", + "Looking for paths with length: 3 for node RPS6KA1_S380 and HSPB1\n", + "i_search = 4\n", + "Looking for paths with length: 4 for node RPS6KA1_S380 and HSPB1\n", + "looking for paths in the network with length: 0 for node RPS6KA1_S380 and MAPK14\n", + "looking for paths in the network with length: 1 for node RPS6KA1_S380 and MAPK14\n", + "looking for paths in the network with length: 2 for node RPS6KA1_S380 and MAPK14\n", + "looking for paths in the network with length: 3 for node RPS6KA1_S380 and MAPK14\n", + "looking for paths in the network with length: 4 for node RPS6KA1_S380 and MAPK14\n", + "looking for paths in the network with length: 5 for node RPS6KA1_S380 and MAPK14\n", + "looking for paths in the network with length: 6 for node RPS6KA1_S380 and MAPK14\n", + "looking for paths in the network with length: 7 for node RPS6KA1_S380 and MAPK14\n", + "looking for paths in the network with length: 8 for node RPS6KA1_S380 and MAPK14\n", + "looking for paths in the network with length: 9 for node RPS6KA1_S380 and MAPK14\n", + "looking for paths in the network with length: 10 for node RPS6KA1_S380 and MAPK14\n", + "i_search = 4\n", + "Looking for paths with length: 0 for node RPS6KA1_S380 and MAPK14\n", + "i_search = 4\n", + "Looking for paths with length: 1 for node RPS6KA1_S380 and MAPK14\n", + "i_search = 4\n", + "Looking for paths with length: 2 for node RPS6KA1_S380 and MAPK14\n", + "i_search = 4\n", + "Looking for paths with length: 3 for node RPS6KA1_S380 and MAPK14\n", + "i_search = 4\n", + "Looking for paths with length: 4 for node RPS6KA1_S380 and MAPK14\n", + "looking for paths in the network with length: 0 for node RPS6KA1_S380 and MAP2K1\n", + "looking for paths in the network with length: 1 for node RPS6KA1_S380 and MAP2K1\n", + "looking for paths in the network with length: 2 for node RPS6KA1_S380 and MAP2K1\n", + "looking for paths in the network with length: 3 for node RPS6KA1_S380 and MAP2K1\n", + "looking for paths in the network with length: 4 for node RPS6KA1_S380 and MAP2K1\n", + "looking for paths in the network with length: 5 for node RPS6KA1_S380 and MAP2K1\n", + "looking for paths in the network with length: 6 for node RPS6KA1_S380 and MAP2K1\n", + "looking for paths in the network with length: 7 for node RPS6KA1_S380 and MAP2K1\n", + "looking for paths in the network with length: 8 for node RPS6KA1_S380 and MAP2K1\n", + "looking for paths in the network with length: 9 for node RPS6KA1_S380 and MAP2K1\n", + "looking for paths in the network with length: 10 for node RPS6KA1_S380 and MAP2K1\n", + "i_search = 4\n", + "Looking for paths with length: 0 for node RPS6KA1_S380 and MAP2K1\n", + "i_search = 4\n", + "Looking for paths with length: 1 for node RPS6KA1_S380 and MAP2K1\n", + "i_search = 4\n", + "Looking for paths with length: 2 for node RPS6KA1_S380 and MAP2K1\n", + "i_search = 4\n", + "Looking for paths with length: 3 for node RPS6KA1_S380 and MAP2K1\n", + "i_search = 4\n", + "Looking for paths with length: 4 for node RPS6KA1_S380 and MAP2K1\n", + "looking for paths in the network with length: 0 for node RPS6KA1_S380 and RPS6KA1\n", + "looking for paths in the network with length: 1 for node RPS6KA1_S380 and RPS6KA1\n", + "looking for paths in the network with length: 2 for node RPS6KA1_S380 and RPS6KA1\n", + "looking for paths in the network with length: 3 for node RPS6KA1_S380 and RPS6KA1\n", + "looking for paths in the network with length: 4 for node RPS6KA1_S380 and RPS6KA1\n", + "looking for paths in the network with length: 5 for node RPS6KA1_S380 and RPS6KA1\n", + "looking for paths in the network with length: 6 for node RPS6KA1_S380 and RPS6KA1\n", + "looking for paths in the network with length: 7 for node RPS6KA1_S380 and RPS6KA1\n", + "looking for paths in the network with length: 8 for node RPS6KA1_S380 and RPS6KA1\n", + "looking for paths in the network with length: 9 for node RPS6KA1_S380 and RPS6KA1\n", + "looking for paths in the network with length: 10 for node RPS6KA1_S380 and RPS6KA1\n", + "i_search = 4\n", + "Looking for paths with length: 0 for node RPS6KA1_S380 and RPS6KA1\n", + "i_search = 4\n", + "Looking for paths with length: 1 for node RPS6KA1_S380 and RPS6KA1\n", + "i_search = 4\n", + "Looking for paths with length: 2 for node RPS6KA1_S380 and RPS6KA1\n", + "i_search = 4\n", + "Looking for paths with length: 3 for node RPS6KA1_S380 and RPS6KA1\n", + "i_search = 4\n", + "Looking for paths with length: 4 for node RPS6KA1_S380 and RPS6KA1\n", + "looking for paths in the network with length: 0 for node RPS6KA1_S380 and CREB1\n", + "looking for paths in the network with length: 1 for node RPS6KA1_S380 and CREB1\n", + "looking for paths in the network with length: 2 for node RPS6KA1_S380 and CREB1\n", + "looking for paths in the network with length: 3 for node RPS6KA1_S380 and CREB1\n", + "looking for paths in the network with length: 4 for node RPS6KA1_S380 and CREB1\n", + "looking for paths in the network with length: 5 for node RPS6KA1_S380 and CREB1\n", + "looking for paths in the network with length: 6 for node RPS6KA1_S380 and CREB1\n", + "looking for paths in the network with length: 7 for node RPS6KA1_S380 and CREB1\n", + "looking for paths in the network with length: 8 for node RPS6KA1_S380 and CREB1\n", + "looking for paths in the network with length: 9 for node RPS6KA1_S380 and CREB1\n", + "looking for paths in the network with length: 10 for node RPS6KA1_S380 and CREB1\n", + "i_search = 4\n", + "Looking for paths with length: 0 for node RPS6KA1_S380 and CREB1\n", + "i_search = 4\n", + "Looking for paths with length: 1 for node RPS6KA1_S380 and CREB1\n", + "i_search = 4\n", + "Looking for paths with length: 2 for node RPS6KA1_S380 and CREB1\n", + "i_search = 4\n", + "Looking for paths with length: 3 for node RPS6KA1_S380 and CREB1\n", + "i_search = 4\n", + "Looking for paths with length: 4 for node RPS6KA1_S380 and CREB1\n", + "looking for paths in the network with length: 0 for node RPS6KA1_S380 and NFKBIA\n", + "looking for paths in the network with length: 1 for node RPS6KA1_S380 and NFKBIA\n", + "looking for paths in the network with length: 2 for node RPS6KA1_S380 and NFKBIA\n", + "looking for paths in the network with length: 3 for node RPS6KA1_S380 and NFKBIA\n", + "looking for paths in the network with length: 4 for node RPS6KA1_S380 and NFKBIA\n", + "looking for paths in the network with length: 5 for node RPS6KA1_S380 and NFKBIA\n", + "looking for paths in the network with length: 6 for node RPS6KA1_S380 and NFKBIA\n", + "looking for paths in the network with length: 7 for node RPS6KA1_S380 and NFKBIA\n", + "looking for paths in the network with length: 8 for node RPS6KA1_S380 and NFKBIA\n", + "looking for paths in the network with length: 9 for node RPS6KA1_S380 and NFKBIA\n", + "looking for paths in the network with length: 10 for node RPS6KA1_S380 and NFKBIA\n", + "i_search = 4\n", + "Looking for paths with length: 0 for node RPS6KA1_S380 and NFKBIA\n", + "i_search = 4\n", + "Looking for paths with length: 1 for node RPS6KA1_S380 and NFKBIA\n", + "i_search = 4\n", + "Looking for paths with length: 2 for node RPS6KA1_S380 and NFKBIA\n", + "i_search = 4\n", + "Looking for paths with length: 3 for node RPS6KA1_S380 and NFKBIA\n", + "i_search = 4\n", + "Looking for paths with length: 4 for node RPS6KA1_S380 and NFKBIA\n", + "looking for paths in the network with length: 0 for node RPS6KA1_S380 and MTOR\n", + "looking for paths in the network with length: 1 for node RPS6KA1_S380 and MTOR\n", + "looking for paths in the network with length: 2 for node RPS6KA1_S380 and MTOR\n", + "looking for paths in the network with length: 3 for node RPS6KA1_S380 and MTOR\n", + "looking for paths in the network with length: 4 for node RPS6KA1_S380 and MTOR\n", + "looking for paths in the network with length: 5 for node RPS6KA1_S380 and MTOR\n", + "looking for paths in the network with length: 6 for node RPS6KA1_S380 and MTOR\n", + "looking for paths in the network with length: 7 for node RPS6KA1_S380 and MTOR\n", + "looking for paths in the network with length: 8 for node RPS6KA1_S380 and MTOR\n", + "looking for paths in the network with length: 9 for node RPS6KA1_S380 and MTOR\n", + "looking for paths in the network with length: 10 for node RPS6KA1_S380 and MTOR\n", + "i_search = 4\n", + "Looking for paths with length: 0 for node RPS6KA1_S380 and MTOR\n", + "i_search = 4\n", + "Looking for paths with length: 1 for node RPS6KA1_S380 and MTOR\n", + "i_search = 4\n", + "Looking for paths with length: 2 for node RPS6KA1_S380 and MTOR\n", + "i_search = 4\n", + "Looking for paths with length: 3 for node RPS6KA1_S380 and MTOR\n", + "i_search = 4\n", + "Looking for paths with length: 4 for node RPS6KA1_S380 and MTOR\n", + "looking for paths in the network with length: 0 for node RPS6KA1_S380 and JUN\n", + "looking for paths in the network with length: 1 for node RPS6KA1_S380 and JUN\n", + "looking for paths in the network with length: 2 for node RPS6KA1_S380 and JUN\n", + "looking for paths in the network with length: 3 for node RPS6KA1_S380 and JUN\n", + "looking for paths in the network with length: 4 for node RPS6KA1_S380 and JUN\n", + "looking for paths in the network with length: 5 for node RPS6KA1_S380 and JUN\n", + "looking for paths in the network with length: 6 for node RPS6KA1_S380 and JUN\n", + "looking for paths in the network with length: 7 for node RPS6KA1_S380 and JUN\n", + "looking for paths in the network with length: 8 for node RPS6KA1_S380 and JUN\n", + "looking for paths in the network with length: 9 for node RPS6KA1_S380 and JUN\n", + "looking for paths in the network with length: 10 for node RPS6KA1_S380 and JUN\n", + "i_search = 4\n", + "Looking for paths with length: 0 for node RPS6KA1_S380 and JUN\n", + "i_search = 4\n", + "Looking for paths with length: 1 for node RPS6KA1_S380 and JUN\n", + "i_search = 4\n", + "Looking for paths with length: 2 for node RPS6KA1_S380 and JUN\n", + "i_search = 4\n", + "Looking for paths with length: 3 for node RPS6KA1_S380 and JUN\n", + "i_search = 4\n", + "Looking for paths with length: 4 for node RPS6KA1_S380 and JUN\n", + "looking for paths in the network with length: 0 for node RPS6KA1_S380 and EGFR\n", + "looking for paths in the network with length: 1 for node RPS6KA1_S380 and EGFR\n", + "looking for paths in the network with length: 2 for node RPS6KA1_S380 and EGFR\n", + "looking for paths in the network with length: 3 for node RPS6KA1_S380 and EGFR\n", + "looking for paths in the network with length: 4 for node RPS6KA1_S380 and EGFR\n", + "looking for paths in the network with length: 5 for node RPS6KA1_S380 and EGFR\n", + "looking for paths in the network with length: 6 for node RPS6KA1_S380 and EGFR\n", + "looking for paths in the network with length: 7 for node RPS6KA1_S380 and EGFR\n", + "looking for paths in the network with length: 8 for node RPS6KA1_S380 and EGFR\n", + "looking for paths in the network with length: 9 for node RPS6KA1_S380 and EGFR\n", + "looking for paths in the network with length: 10 for node RPS6KA1_S380 and EGFR\n", + "i_search = 4\n", + "Looking for paths with length: 0 for node RPS6KA1_S380 and EGFR\n", + "i_search = 4\n", + "Looking for paths with length: 1 for node RPS6KA1_S380 and EGFR\n", + "i_search = 4\n", + "Looking for paths with length: 2 for node RPS6KA1_S380 and EGFR\n", + "i_search = 4\n", + "Looking for paths with length: 3 for node RPS6KA1_S380 and EGFR\n", + "i_search = 4\n", + "Looking for paths with length: 4 for node RPS6KA1_S380 and EGFR\n", + "looking for paths in the network with length: 0 for node RPS6KA1_S380 and MAPK3\n", + "looking for paths in the network with length: 1 for node RPS6KA1_S380 and MAPK3\n", + "looking for paths in the network with length: 2 for node RPS6KA1_S380 and MAPK3\n", + "looking for paths in the network with length: 3 for node RPS6KA1_S380 and MAPK3\n", + "looking for paths in the network with length: 4 for node RPS6KA1_S380 and MAPK3\n", + "looking for paths in the network with length: 5 for node RPS6KA1_S380 and MAPK3\n", + "looking for paths in the network with length: 6 for node RPS6KA1_S380 and MAPK3\n", + "looking for paths in the network with length: 7 for node RPS6KA1_S380 and MAPK3\n", + "looking for paths in the network with length: 8 for node RPS6KA1_S380 and MAPK3\n", + "looking for paths in the network with length: 9 for node RPS6KA1_S380 and MAPK3\n", + "looking for paths in the network with length: 10 for node RPS6KA1_S380 and MAPK3\n", + "i_search = 4\n", + "Looking for paths with length: 0 for node RPS6KA1_S380 and MAPK3\n", + "i_search = 4\n", + "Looking for paths with length: 1 for node RPS6KA1_S380 and MAPK3\n", + "i_search = 4\n", + "Looking for paths with length: 2 for node RPS6KA1_S380 and MAPK3\n", + "i_search = 4\n", + "Looking for paths with length: 3 for node RPS6KA1_S380 and MAPK3\n", + "i_search = 4\n", + "Looking for paths with length: 4 for node RPS6KA1_S380 and MAPK3\n", + "looking for paths in the network with length: 0 for node RPS6KA1_S380 and PTPN11\n", + "looking for paths in the network with length: 1 for node RPS6KA1_S380 and PTPN11\n", + "looking for paths in the network with length: 2 for node RPS6KA1_S380 and PTPN11\n", + "looking for paths in the network with length: 3 for node RPS6KA1_S380 and PTPN11\n", + "looking for paths in the network with length: 4 for node RPS6KA1_S380 and PTPN11\n", + "looking for paths in the network with length: 5 for node RPS6KA1_S380 and PTPN11\n", + "looking for paths in the network with length: 6 for node RPS6KA1_S380 and PTPN11\n", + "looking for paths in the network with length: 7 for node RPS6KA1_S380 and PTPN11\n", + "looking for paths in the network with length: 8 for node RPS6KA1_S380 and PTPN11\n", + "looking for paths in the network with length: 9 for node RPS6KA1_S380 and PTPN11\n", + "looking for paths in the network with length: 10 for node RPS6KA1_S380 and PTPN11\n", + "i_search = 4\n", + "Looking for paths with length: 0 for node RPS6KA1_S380 and PTPN11\n", + "i_search = 4\n", + "Looking for paths with length: 1 for node RPS6KA1_S380 and PTPN11\n", + "i_search = 4\n", + "Looking for paths with length: 2 for node RPS6KA1_S380 and PTPN11\n", + "i_search = 4\n", + "Looking for paths with length: 3 for node RPS6KA1_S380 and PTPN11\n", + "i_search = 4\n", + "Looking for paths with length: 4 for node RPS6KA1_S380 and PTPN11\n", + "looking for paths in the network with length: 0 for node RPS6KA1_S380 and STAT3\n", + "looking for paths in the network with length: 1 for node RPS6KA1_S380 and STAT3\n", + "looking for paths in the network with length: 2 for node RPS6KA1_S380 and STAT3\n", + "looking for paths in the network with length: 3 for node RPS6KA1_S380 and STAT3\n", + "looking for paths in the network with length: 4 for node RPS6KA1_S380 and STAT3\n", + "looking for paths in the network with length: 5 for node RPS6KA1_S380 and STAT3\n", + "looking for paths in the network with length: 6 for node RPS6KA1_S380 and STAT3\n", + "looking for paths in the network with length: 7 for node RPS6KA1_S380 and STAT3\n", + "looking for paths in the network with length: 8 for node RPS6KA1_S380 and STAT3\n", + "looking for paths in the network with length: 9 for node RPS6KA1_S380 and STAT3\n", + "looking for paths in the network with length: 10 for node RPS6KA1_S380 and STAT3\n", + "i_search = 4\n", + "Looking for paths with length: 0 for node RPS6KA1_S380 and STAT3\n", + "i_search = 4\n", + "Looking for paths with length: 1 for node RPS6KA1_S380 and STAT3\n", + "i_search = 4\n", + "Looking for paths with length: 2 for node RPS6KA1_S380 and STAT3\n", + "i_search = 4\n", + "Looking for paths with length: 3 for node RPS6KA1_S380 and STAT3\n", + "i_search = 4\n", + "Looking for paths with length: 4 for node RPS6KA1_S380 and STAT3\n", + "looking for paths in the network with length: 0 for node RPS6KA1_S380 and CHEK2\n", + "looking for paths in the network with length: 1 for node RPS6KA1_S380 and CHEK2\n", + "looking for paths in the network with length: 2 for node RPS6KA1_S380 and CHEK2\n", + "looking for paths in the network with length: 3 for node RPS6KA1_S380 and CHEK2\n", + "looking for paths in the network with length: 4 for node RPS6KA1_S380 and CHEK2\n", + "looking for paths in the network with length: 5 for node RPS6KA1_S380 and CHEK2\n", + "looking for paths in the network with length: 6 for node RPS6KA1_S380 and CHEK2\n", + "looking for paths in the network with length: 7 for node RPS6KA1_S380 and CHEK2\n", + "looking for paths in the network with length: 8 for node RPS6KA1_S380 and CHEK2\n", + "looking for paths in the network with length: 9 for node RPS6KA1_S380 and CHEK2\n", + "looking for paths in the network with length: 10 for node RPS6KA1_S380 and CHEK2\n", + "i_search = 4\n", + "Looking for paths with length: 0 for node RPS6KA1_S380 and CHEK2\n", + "i_search = 4\n", + "Looking for paths with length: 1 for node RPS6KA1_S380 and CHEK2\n", + "i_search = 4\n", + "Looking for paths with length: 2 for node RPS6KA1_S380 and CHEK2\n", + "i_search = 4\n", + "Looking for paths with length: 3 for node RPS6KA1_S380 and CHEK2\n", + "i_search = 4\n", + "Looking for paths with length: 4 for node RPS6KA1_S380 and CHEK2\n", + "looking for paths in the network with length: 0 for node RPS6KA1_S380 and RELA\n", + "looking for paths in the network with length: 1 for node RPS6KA1_S380 and RELA\n", + "looking for paths in the network with length: 2 for node RPS6KA1_S380 and RELA\n", + "looking for paths in the network with length: 3 for node RPS6KA1_S380 and RELA\n", + "looking for paths in the network with length: 4 for node RPS6KA1_S380 and RELA\n", + "looking for paths in the network with length: 5 for node RPS6KA1_S380 and RELA\n", + "looking for paths in the network with length: 6 for node RPS6KA1_S380 and RELA\n", + "looking for paths in the network with length: 7 for node RPS6KA1_S380 and RELA\n", + "looking for paths in the network with length: 8 for node RPS6KA1_S380 and RELA\n", + "looking for paths in the network with length: 9 for node RPS6KA1_S380 and RELA\n", + "looking for paths in the network with length: 10 for node RPS6KA1_S380 and RELA\n", + "i_search = 4\n", + "Looking for paths with length: 0 for node RPS6KA1_S380 and RELA\n", + "i_search = 4\n", + "Looking for paths with length: 1 for node RPS6KA1_S380 and RELA\n", + "i_search = 4\n", + "Looking for paths with length: 2 for node RPS6KA1_S380 and RELA\n", + "i_search = 4\n", + "Looking for paths with length: 3 for node RPS6KA1_S380 and RELA\n", + "i_search = 4\n", + "Looking for paths with length: 4 for node RPS6KA1_S380 and RELA\n", + "looking for paths in the network with length: 0 for node RPS6KA1_S380 and MARCKS\n", + "looking for paths in the network with length: 1 for node RPS6KA1_S380 and MARCKS\n", + "looking for paths in the network with length: 2 for node RPS6KA1_S380 and MARCKS\n", + "looking for paths in the network with length: 3 for node RPS6KA1_S380 and MARCKS\n", + "looking for paths in the network with length: 4 for node RPS6KA1_S380 and MARCKS\n", + "looking for paths in the network with length: 5 for node RPS6KA1_S380 and MARCKS\n", + "looking for paths in the network with length: 6 for node RPS6KA1_S380 and MARCKS\n", + "looking for paths in the network with length: 7 for node RPS6KA1_S380 and MARCKS\n", + "looking for paths in the network with length: 8 for node RPS6KA1_S380 and MARCKS\n", + "looking for paths in the network with length: 9 for node RPS6KA1_S380 and MARCKS\n", + "looking for paths in the network with length: 10 for node RPS6KA1_S380 and MARCKS\n", + "i_search = 4\n", + "Looking for paths with length: 0 for node RPS6KA1_S380 and MARCKS\n", + "i_search = 4\n", + "Looking for paths with length: 1 for node RPS6KA1_S380 and MARCKS\n", + "i_search = 4\n", + "Looking for paths with length: 2 for node RPS6KA1_S380 and MARCKS\n", + "i_search = 4\n", + "Looking for paths with length: 3 for node RPS6KA1_S380 and MARCKS\n", + "i_search = 4\n", + "Looking for paths with length: 4 for node RPS6KA1_S380 and MARCKS\n", + "looking for paths in the network with length: 0 for node CREB1_S133 and NFKBIA_S32\n", + "looking for paths in the network with length: 1 for node CREB1_S133 and NFKBIA_S32\n", + "looking for paths in the network with length: 2 for node CREB1_S133 and NFKBIA_S32\n", + "looking for paths in the network with length: 3 for node CREB1_S133 and NFKBIA_S32\n", + "looking for paths in the network with length: 4 for node CREB1_S133 and NFKBIA_S32\n", + "looking for paths in the network with length: 5 for node CREB1_S133 and NFKBIA_S32\n", + "looking for paths in the network with length: 6 for node CREB1_S133 and NFKBIA_S32\n", + "looking for paths in the network with length: 7 for node CREB1_S133 and NFKBIA_S32\n", + "looking for paths in the network with length: 8 for node CREB1_S133 and NFKBIA_S32\n", + "looking for paths in the network with length: 9 for node CREB1_S133 and NFKBIA_S32\n", + "looking for paths in the network with length: 10 for node CREB1_S133 and NFKBIA_S32\n", + "i_search = 4\n", + "Looking for paths with length: 0 for node CREB1_S133 and NFKBIA_S32\n", + "i_search = 4\n", + "Looking for paths with length: 1 for node CREB1_S133 and NFKBIA_S32\n", + "i_search = 4\n", + "Looking for paths with length: 2 for node CREB1_S133 and NFKBIA_S32\n", + "i_search = 4\n", + "Looking for paths with length: 3 for node CREB1_S133 and NFKBIA_S32\n", + "i_search = 4\n", + "Looking for paths with length: 4 for node CREB1_S133 and NFKBIA_S32\n", + "looking for paths in the network with length: 0 for node CREB1_S133 and NFKBIA_S36\n", + "looking for paths in the network with length: 1 for node CREB1_S133 and NFKBIA_S36\n", + "looking for paths in the network with length: 2 for node CREB1_S133 and NFKBIA_S36\n", + "looking for paths in the network with length: 3 for node CREB1_S133 and NFKBIA_S36\n", + "looking for paths in the network with length: 4 for node CREB1_S133 and NFKBIA_S36\n", + "looking for paths in the network with length: 5 for node CREB1_S133 and NFKBIA_S36\n", + "looking for paths in the network with length: 6 for node CREB1_S133 and NFKBIA_S36\n", + "looking for paths in the network with length: 7 for node CREB1_S133 and NFKBIA_S36\n", + "looking for paths in the network with length: 8 for node CREB1_S133 and NFKBIA_S36\n", + "looking for paths in the network with length: 9 for node CREB1_S133 and NFKBIA_S36\n", + "looking for paths in the network with length: 10 for node CREB1_S133 and NFKBIA_S36\n", + "i_search = 4\n", + "Looking for paths with length: 0 for node CREB1_S133 and NFKBIA_S36\n", + "i_search = 4\n", + "Looking for paths with length: 1 for node CREB1_S133 and NFKBIA_S36\n", + "i_search = 4\n", + "Looking for paths with length: 2 for node CREB1_S133 and NFKBIA_S36\n", + "i_search = 4\n", + "Looking for paths with length: 3 for node CREB1_S133 and NFKBIA_S36\n", + "i_search = 4\n", + "Looking for paths with length: 4 for node CREB1_S133 and NFKBIA_S36\n", + "looking for paths in the network with length: 0 for node CREB1_S133 and MTOR_S2448\n", + "looking for paths in the network with length: 1 for node CREB1_S133 and MTOR_S2448\n", + "looking for paths in the network with length: 2 for node CREB1_S133 and MTOR_S2448\n", + "looking for paths in the network with length: 3 for node CREB1_S133 and MTOR_S2448\n", + "looking for paths in the network with length: 4 for node CREB1_S133 and MTOR_S2448\n", + "looking for paths in the network with length: 5 for node CREB1_S133 and MTOR_S2448\n", + "looking for paths in the network with length: 6 for node CREB1_S133 and MTOR_S2448\n", + "looking for paths in the network with length: 7 for node CREB1_S133 and MTOR_S2448\n", + "looking for paths in the network with length: 8 for node CREB1_S133 and MTOR_S2448\n", + "looking for paths in the network with length: 9 for node CREB1_S133 and MTOR_S2448\n", + "looking for paths in the network with length: 10 for node CREB1_S133 and MTOR_S2448\n", + "i_search = 4\n", + "Looking for paths with length: 0 for node CREB1_S133 and MTOR_S2448\n", + "i_search = 4\n", + "Looking for paths with length: 1 for node CREB1_S133 and MTOR_S2448\n", + "i_search = 4\n", + "Looking for paths with length: 2 for node CREB1_S133 and MTOR_S2448\n", + "i_search = 4\n", + "Looking for paths with length: 3 for node CREB1_S133 and MTOR_S2448\n", + "i_search = 4\n", + "Looking for paths with length: 4 for node CREB1_S133 and MTOR_S2448\n", + "looking for paths in the network with length: 0 for node CREB1_S133 and JUN_S63\n", + "looking for paths in the network with length: 1 for node CREB1_S133 and JUN_S63\n", + "looking for paths in the network with length: 2 for node CREB1_S133 and JUN_S63\n", + "looking for paths in the network with length: 3 for node CREB1_S133 and JUN_S63\n", + "looking for paths in the network with length: 4 for node CREB1_S133 and JUN_S63\n", + "looking for paths in the network with length: 5 for node CREB1_S133 and JUN_S63\n", + "looking for paths in the network with length: 6 for node CREB1_S133 and JUN_S63\n", + "looking for paths in the network with length: 7 for node CREB1_S133 and JUN_S63\n", + "looking for paths in the network with length: 8 for node CREB1_S133 and JUN_S63\n", + "looking for paths in the network with length: 9 for node CREB1_S133 and JUN_S63\n", + "looking for paths in the network with length: 10 for node CREB1_S133 and JUN_S63\n", + "i_search = 4\n", + "Looking for paths with length: 0 for node CREB1_S133 and JUN_S63\n", + "i_search = 4\n", + "Looking for paths with length: 1 for node CREB1_S133 and JUN_S63\n", + "i_search = 4\n", + "Looking for paths with length: 2 for node CREB1_S133 and JUN_S63\n", + "i_search = 4\n", + "Looking for paths with length: 3 for node CREB1_S133 and JUN_S63\n", + "i_search = 4\n", + "Looking for paths with length: 4 for node CREB1_S133 and JUN_S63\n", + "looking for paths in the network with length: 0 for node CREB1_S133 and EGFR_Y1068\n", + "looking for paths in the network with length: 1 for node CREB1_S133 and EGFR_Y1068\n", + "looking for paths in the network with length: 2 for node CREB1_S133 and EGFR_Y1068\n", + "looking for paths in the network with length: 3 for node CREB1_S133 and EGFR_Y1068\n", + "looking for paths in the network with length: 4 for node CREB1_S133 and EGFR_Y1068\n", + "looking for paths in the network with length: 5 for node CREB1_S133 and EGFR_Y1068\n", + "looking for paths in the network with length: 6 for node CREB1_S133 and EGFR_Y1068\n", + "looking for paths in the network with length: 7 for node CREB1_S133 and EGFR_Y1068\n", + "looking for paths in the network with length: 8 for node CREB1_S133 and EGFR_Y1068\n", + "looking for paths in the network with length: 9 for node CREB1_S133 and EGFR_Y1068\n", + "looking for paths in the network with length: 10 for node CREB1_S133 and EGFR_Y1068\n", + "i_search = 4\n", + "Looking for paths with length: 0 for node CREB1_S133 and EGFR_Y1068\n", + "i_search = 4\n", + "Looking for paths with length: 1 for node CREB1_S133 and EGFR_Y1068\n", + "i_search = 4\n", + "Looking for paths with length: 2 for node CREB1_S133 and EGFR_Y1068\n", + "i_search = 4\n", + "Looking for paths with length: 3 for node CREB1_S133 and EGFR_Y1068\n", + "i_search = 4\n", + "Looking for paths with length: 4 for node CREB1_S133 and EGFR_Y1068\n", + "looking for paths in the network with length: 0 for node CREB1_S133 and MAPK3_T202\n", + "looking for paths in the network with length: 1 for node CREB1_S133 and MAPK3_T202\n", + "looking for paths in the network with length: 2 for node CREB1_S133 and MAPK3_T202\n", + "looking for paths in the network with length: 3 for node CREB1_S133 and MAPK3_T202\n", + "looking for paths in the network with length: 4 for node CREB1_S133 and MAPK3_T202\n", + "looking for paths in the network with length: 5 for node CREB1_S133 and MAPK3_T202\n", + "looking for paths in the network with length: 6 for node CREB1_S133 and MAPK3_T202\n", + "looking for paths in the network with length: 7 for node CREB1_S133 and MAPK3_T202\n", + "looking for paths in the network with length: 8 for node CREB1_S133 and MAPK3_T202\n", + "looking for paths in the network with length: 9 for node CREB1_S133 and MAPK3_T202\n", + "looking for paths in the network with length: 10 for node CREB1_S133 and MAPK3_T202\n", + "i_search = 4\n", + "Looking for paths with length: 0 for node CREB1_S133 and MAPK3_T202\n", + "i_search = 4\n", + "Looking for paths with length: 1 for node CREB1_S133 and MAPK3_T202\n", + "i_search = 4\n", + "Looking for paths with length: 2 for node CREB1_S133 and MAPK3_T202\n", + "i_search = 4\n", + "Looking for paths with length: 3 for node CREB1_S133 and MAPK3_T202\n", + "i_search = 4\n", + "Looking for paths with length: 4 for node CREB1_S133 and MAPK3_T202\n", + "looking for paths in the network with length: 0 for node CREB1_S133 and MAPK3_Y204\n", + "looking for paths in the network with length: 1 for node CREB1_S133 and MAPK3_Y204\n", + "looking for paths in the network with length: 2 for node CREB1_S133 and MAPK3_Y204\n", + "looking for paths in the network with length: 3 for node CREB1_S133 and MAPK3_Y204\n", + "looking for paths in the network with length: 4 for node CREB1_S133 and MAPK3_Y204\n", + "looking for paths in the network with length: 5 for node CREB1_S133 and MAPK3_Y204\n", + "looking for paths in the network with length: 6 for node CREB1_S133 and MAPK3_Y204\n", + "looking for paths in the network with length: 7 for node CREB1_S133 and MAPK3_Y204\n", + "looking for paths in the network with length: 8 for node CREB1_S133 and MAPK3_Y204\n", + "looking for paths in the network with length: 9 for node CREB1_S133 and MAPK3_Y204\n", + "looking for paths in the network with length: 10 for node CREB1_S133 and MAPK3_Y204\n", + "i_search = 4\n", + "Looking for paths with length: 0 for node CREB1_S133 and MAPK3_Y204\n", + "i_search = 4\n", + "Looking for paths with length: 1 for node CREB1_S133 and MAPK3_Y204\n", + "i_search = 4\n", + "Looking for paths with length: 2 for node CREB1_S133 and MAPK3_Y204\n", + "i_search = 4\n", + "Looking for paths with length: 3 for node CREB1_S133 and MAPK3_Y204\n", + "i_search = 4\n", + "Looking for paths with length: 4 for node CREB1_S133 and MAPK3_Y204\n", + "looking for paths in the network with length: 0 for node CREB1_S133 and PTPN11_Y542\n", + "looking for paths in the network with length: 1 for node CREB1_S133 and PTPN11_Y542\n", + "looking for paths in the network with length: 2 for node CREB1_S133 and PTPN11_Y542\n", + "looking for paths in the network with length: 3 for node CREB1_S133 and PTPN11_Y542\n", + "looking for paths in the network with length: 4 for node CREB1_S133 and PTPN11_Y542\n", + "looking for paths in the network with length: 5 for node CREB1_S133 and PTPN11_Y542\n", + "looking for paths in the network with length: 6 for node CREB1_S133 and PTPN11_Y542\n", + "looking for paths in the network with length: 7 for node CREB1_S133 and PTPN11_Y542\n", + "looking for paths in the network with length: 8 for node CREB1_S133 and PTPN11_Y542\n", + "looking for paths in the network with length: 9 for node CREB1_S133 and PTPN11_Y542\n", + "looking for paths in the network with length: 10 for node CREB1_S133 and PTPN11_Y542\n", + "i_search = 4\n", + "Looking for paths with length: 0 for node CREB1_S133 and PTPN11_Y542\n", + "i_search = 4\n", + "Looking for paths with length: 1 for node CREB1_S133 and PTPN11_Y542\n", + "i_search = 4\n", + "Looking for paths with length: 2 for node CREB1_S133 and PTPN11_Y542\n", + "i_search = 4\n", + "Looking for paths with length: 3 for node CREB1_S133 and PTPN11_Y542\n", + "i_search = 4\n", + "Looking for paths with length: 4 for node CREB1_S133 and PTPN11_Y542\n", + "looking for paths in the network with length: 0 for node CREB1_S133 and STAT3_Y705\n", + "looking for paths in the network with length: 1 for node CREB1_S133 and STAT3_Y705\n", + "looking for paths in the network with length: 2 for node CREB1_S133 and STAT3_Y705\n", + "looking for paths in the network with length: 3 for node CREB1_S133 and STAT3_Y705\n", + "looking for paths in the network with length: 4 for node CREB1_S133 and STAT3_Y705\n", + "looking for paths in the network with length: 5 for node CREB1_S133 and STAT3_Y705\n", + "looking for paths in the network with length: 6 for node CREB1_S133 and STAT3_Y705\n", + "looking for paths in the network with length: 7 for node CREB1_S133 and STAT3_Y705\n", + "looking for paths in the network with length: 8 for node CREB1_S133 and STAT3_Y705\n", + "looking for paths in the network with length: 9 for node CREB1_S133 and STAT3_Y705\n", + "looking for paths in the network with length: 10 for node CREB1_S133 and STAT3_Y705\n", + "i_search = 4\n", + "Looking for paths with length: 0 for node CREB1_S133 and STAT3_Y705\n", + "i_search = 4\n", + "Looking for paths with length: 1 for node CREB1_S133 and STAT3_Y705\n", + "i_search = 4\n", + "Looking for paths with length: 2 for node CREB1_S133 and STAT3_Y705\n", + "i_search = 4\n", + "Looking for paths with length: 3 for node CREB1_S133 and STAT3_Y705\n", + "i_search = 4\n", + "Looking for paths with length: 4 for node CREB1_S133 and STAT3_Y705\n", + "looking for paths in the network with length: 0 for node CREB1_S133 and CHEK2_T68\n", + "looking for paths in the network with length: 1 for node CREB1_S133 and CHEK2_T68\n", + "looking for paths in the network with length: 2 for node CREB1_S133 and CHEK2_T68\n", + "looking for paths in the network with length: 3 for node CREB1_S133 and CHEK2_T68\n", + "looking for paths in the network with length: 4 for node CREB1_S133 and CHEK2_T68\n", + "looking for paths in the network with length: 5 for node CREB1_S133 and CHEK2_T68\n", + "looking for paths in the network with length: 6 for node CREB1_S133 and CHEK2_T68\n", + "looking for paths in the network with length: 7 for node CREB1_S133 and CHEK2_T68\n", + "looking for paths in the network with length: 8 for node CREB1_S133 and CHEK2_T68\n", + "looking for paths in the network with length: 9 for node CREB1_S133 and CHEK2_T68\n", + "looking for paths in the network with length: 10 for node CREB1_S133 and CHEK2_T68\n", + "i_search = 4\n", + "Looking for paths with length: 0 for node CREB1_S133 and CHEK2_T68\n", + "i_search = 4\n", + "Looking for paths with length: 1 for node CREB1_S133 and CHEK2_T68\n", + "i_search = 4\n", + "Looking for paths with length: 2 for node CREB1_S133 and CHEK2_T68\n", + "i_search = 4\n", + "Looking for paths with length: 3 for node CREB1_S133 and CHEK2_T68\n", + "i_search = 4\n", + "Looking for paths with length: 4 for node CREB1_S133 and CHEK2_T68\n", + "looking for paths in the network with length: 0 for node CREB1_S133 and RELA_S536\n", + "looking for paths in the network with length: 1 for node CREB1_S133 and RELA_S536\n", + "looking for paths in the network with length: 2 for node CREB1_S133 and RELA_S536\n", + "looking for paths in the network with length: 3 for node CREB1_S133 and RELA_S536\n", + "looking for paths in the network with length: 4 for node CREB1_S133 and RELA_S536\n", + "looking for paths in the network with length: 5 for node CREB1_S133 and RELA_S536\n", + "looking for paths in the network with length: 6 for node CREB1_S133 and RELA_S536\n", + "looking for paths in the network with length: 7 for node CREB1_S133 and RELA_S536\n", + "looking for paths in the network with length: 8 for node CREB1_S133 and RELA_S536\n", + "looking for paths in the network with length: 9 for node CREB1_S133 and RELA_S536\n", + "looking for paths in the network with length: 10 for node CREB1_S133 and RELA_S536\n", + "i_search = 4\n", + "Looking for paths with length: 0 for node CREB1_S133 and RELA_S536\n", + "i_search = 4\n", + "Looking for paths with length: 1 for node CREB1_S133 and RELA_S536\n", + "i_search = 4\n", + "Looking for paths with length: 2 for node CREB1_S133 and RELA_S536\n", + "i_search = 4\n", + "Looking for paths with length: 3 for node CREB1_S133 and RELA_S536\n", + "i_search = 4\n", + "Looking for paths with length: 4 for node CREB1_S133 and RELA_S536\n", + "looking for paths in the network with length: 0 for node CREB1_S133 and MARCKS_S170\n", + "looking for paths in the network with length: 1 for node CREB1_S133 and MARCKS_S170\n", + "looking for paths in the network with length: 2 for node CREB1_S133 and MARCKS_S170\n", + "looking for paths in the network with length: 3 for node CREB1_S133 and MARCKS_S170\n", + "looking for paths in the network with length: 4 for node CREB1_S133 and MARCKS_S170\n", + "looking for paths in the network with length: 5 for node CREB1_S133 and MARCKS_S170\n", + "looking for paths in the network with length: 6 for node CREB1_S133 and MARCKS_S170\n", + "looking for paths in the network with length: 7 for node CREB1_S133 and MARCKS_S170\n", + "looking for paths in the network with length: 8 for node CREB1_S133 and MARCKS_S170\n", + "looking for paths in the network with length: 9 for node CREB1_S133 and MARCKS_S170\n", + "looking for paths in the network with length: 10 for node CREB1_S133 and MARCKS_S170\n", + "i_search = 4\n", + "Looking for paths with length: 0 for node CREB1_S133 and MARCKS_S170\n", + "i_search = 4\n", + "Looking for paths with length: 1 for node CREB1_S133 and MARCKS_S170\n", + "i_search = 4\n", + "Looking for paths with length: 2 for node CREB1_S133 and MARCKS_S170\n", + "i_search = 4\n", + "Looking for paths with length: 3 for node CREB1_S133 and MARCKS_S170\n", + "i_search = 4\n", + "Looking for paths with length: 4 for node CREB1_S133 and MARCKS_S170\n", + "looking for paths in the network with length: 0 for node CREB1_S133 and SMAD3\n", + "looking for paths in the network with length: 1 for node CREB1_S133 and SMAD3\n", + "looking for paths in the network with length: 2 for node CREB1_S133 and SMAD3\n", + "looking for paths in the network with length: 3 for node CREB1_S133 and SMAD3\n", + "looking for paths in the network with length: 4 for node CREB1_S133 and SMAD3\n", + "looking for paths in the network with length: 5 for node CREB1_S133 and SMAD3\n", + "looking for paths in the network with length: 6 for node CREB1_S133 and SMAD3\n", + "looking for paths in the network with length: 7 for node CREB1_S133 and SMAD3\n", + "looking for paths in the network with length: 8 for node CREB1_S133 and SMAD3\n", + "looking for paths in the network with length: 9 for node CREB1_S133 and SMAD3\n", + "looking for paths in the network with length: 10 for node CREB1_S133 and SMAD3\n", + "i_search = 4\n", + "Looking for paths with length: 0 for node CREB1_S133 and SMAD3\n", + "i_search = 4\n", + "Looking for paths with length: 1 for node CREB1_S133 and SMAD3\n", + "i_search = 4\n", + "Looking for paths with length: 2 for node CREB1_S133 and SMAD3\n", + "i_search = 4\n", + "Looking for paths with length: 3 for node CREB1_S133 and SMAD3\n", + "i_search = 4\n", + "Looking for paths with length: 4 for node CREB1_S133 and SMAD3\n", + "looking for paths in the network with length: 0 for node CREB1_S133 and TP53\n", + "looking for paths in the network with length: 1 for node CREB1_S133 and TP53\n", + "looking for paths in the network with length: 2 for node CREB1_S133 and TP53\n", + "looking for paths in the network with length: 3 for node CREB1_S133 and TP53\n", + "looking for paths in the network with length: 4 for node CREB1_S133 and TP53\n", + "looking for paths in the network with length: 5 for node CREB1_S133 and TP53\n", + "looking for paths in the network with length: 6 for node CREB1_S133 and TP53\n", + "looking for paths in the network with length: 7 for node CREB1_S133 and TP53\n", + "looking for paths in the network with length: 8 for node CREB1_S133 and TP53\n", + "looking for paths in the network with length: 9 for node CREB1_S133 and TP53\n", + "looking for paths in the network with length: 10 for node CREB1_S133 and TP53\n", + "i_search = 4\n", + "Looking for paths with length: 0 for node CREB1_S133 and TP53\n", + "i_search = 4\n", + "Looking for paths with length: 1 for node CREB1_S133 and TP53\n", + "i_search = 4\n", + "Looking for paths with length: 2 for node CREB1_S133 and TP53\n", + "i_search = 4\n", + "Looking for paths with length: 3 for node CREB1_S133 and TP53\n", + "i_search = 4\n", + "Looking for paths with length: 4 for node CREB1_S133 and TP53\n", + "looking for paths in the network with length: 0 for node CREB1_S133 and AKT1S1\n", + "looking for paths in the network with length: 1 for node CREB1_S133 and AKT1S1\n", + "looking for paths in the network with length: 2 for node CREB1_S133 and AKT1S1\n", + "looking for paths in the network with length: 3 for node CREB1_S133 and AKT1S1\n", + "looking for paths in the network with length: 4 for node CREB1_S133 and AKT1S1\n", + "looking for paths in the network with length: 5 for node CREB1_S133 and AKT1S1\n", + "looking for paths in the network with length: 6 for node CREB1_S133 and AKT1S1\n", + "looking for paths in the network with length: 7 for node CREB1_S133 and AKT1S1\n", + "looking for paths in the network with length: 8 for node CREB1_S133 and AKT1S1\n", + "looking for paths in the network with length: 9 for node CREB1_S133 and AKT1S1\n", + "looking for paths in the network with length: 10 for node CREB1_S133 and AKT1S1\n", + "i_search = 4\n", + "Looking for paths with length: 0 for node CREB1_S133 and AKT1S1\n", + "i_search = 4\n", + "Looking for paths with length: 1 for node CREB1_S133 and AKT1S1\n", + "i_search = 4\n", + "Looking for paths with length: 2 for node CREB1_S133 and AKT1S1\n", + "i_search = 4\n", + "Looking for paths with length: 3 for node CREB1_S133 and AKT1S1\n", + "i_search = 4\n", + "Looking for paths with length: 4 for node CREB1_S133 and AKT1S1\n", + "looking for paths in the network with length: 0 for node CREB1_S133 and GSK3B\n", + "looking for paths in the network with length: 1 for node CREB1_S133 and GSK3B\n", + "looking for paths in the network with length: 2 for node CREB1_S133 and GSK3B\n", + "looking for paths in the network with length: 3 for node CREB1_S133 and GSK3B\n", + "looking for paths in the network with length: 4 for node CREB1_S133 and GSK3B\n", + "looking for paths in the network with length: 5 for node CREB1_S133 and GSK3B\n", + "looking for paths in the network with length: 6 for node CREB1_S133 and GSK3B\n", + "looking for paths in the network with length: 7 for node CREB1_S133 and GSK3B\n", + "looking for paths in the network with length: 8 for node CREB1_S133 and GSK3B\n", + "looking for paths in the network with length: 9 for node CREB1_S133 and GSK3B\n", + "looking for paths in the network with length: 10 for node CREB1_S133 and GSK3B\n", + "i_search = 4\n", + "Looking for paths with length: 0 for node CREB1_S133 and GSK3B\n", + "i_search = 4\n", + "Looking for paths with length: 1 for node CREB1_S133 and GSK3B\n", + "i_search = 4\n", + "Looking for paths with length: 2 for node CREB1_S133 and GSK3B\n", + "i_search = 4\n", + "Looking for paths with length: 3 for node CREB1_S133 and GSK3B\n", + "i_search = 4\n", + "Looking for paths with length: 4 for node CREB1_S133 and GSK3B\n", + "looking for paths in the network with length: 0 for node CREB1_S133 and AKT1\n", + "looking for paths in the network with length: 1 for node CREB1_S133 and AKT1\n", + "looking for paths in the network with length: 2 for node CREB1_S133 and AKT1\n", + "looking for paths in the network with length: 3 for node CREB1_S133 and AKT1\n", + "looking for paths in the network with length: 4 for node CREB1_S133 and AKT1\n", + "looking for paths in the network with length: 5 for node CREB1_S133 and AKT1\n", + "looking for paths in the network with length: 6 for node CREB1_S133 and AKT1\n", + "looking for paths in the network with length: 7 for node CREB1_S133 and AKT1\n", + "looking for paths in the network with length: 8 for node CREB1_S133 and AKT1\n", + "looking for paths in the network with length: 9 for node CREB1_S133 and AKT1\n", + "looking for paths in the network with length: 10 for node CREB1_S133 and AKT1\n", + "i_search = 4\n", + "Looking for paths with length: 0 for node CREB1_S133 and AKT1\n", + "i_search = 4\n", + "Looking for paths with length: 1 for node CREB1_S133 and AKT1\n", + "i_search = 4\n", + "Looking for paths with length: 2 for node CREB1_S133 and AKT1\n", + "i_search = 4\n", + "Looking for paths with length: 3 for node CREB1_S133 and AKT1\n", + "i_search = 4\n", + "Looking for paths with length: 4 for node CREB1_S133 and AKT1\n", + "looking for paths in the network with length: 0 for node CREB1_S133 and HSPB1\n", + "looking for paths in the network with length: 1 for node CREB1_S133 and HSPB1\n", + "looking for paths in the network with length: 2 for node CREB1_S133 and HSPB1\n", + "looking for paths in the network with length: 3 for node CREB1_S133 and HSPB1\n", + "looking for paths in the network with length: 4 for node CREB1_S133 and HSPB1\n", + "looking for paths in the network with length: 5 for node CREB1_S133 and HSPB1\n", + "looking for paths in the network with length: 6 for node CREB1_S133 and HSPB1\n", + "looking for paths in the network with length: 7 for node CREB1_S133 and HSPB1\n", + "looking for paths in the network with length: 8 for node CREB1_S133 and HSPB1\n", + "looking for paths in the network with length: 9 for node CREB1_S133 and HSPB1\n", + "looking for paths in the network with length: 10 for node CREB1_S133 and HSPB1\n", + "i_search = 4\n", + "Looking for paths with length: 0 for node CREB1_S133 and HSPB1\n", + "i_search = 4\n", + "Looking for paths with length: 1 for node CREB1_S133 and HSPB1\n", + "i_search = 4\n", + "Looking for paths with length: 2 for node CREB1_S133 and HSPB1\n", + "i_search = 4\n", + "Looking for paths with length: 3 for node CREB1_S133 and HSPB1\n", + "i_search = 4\n", + "Looking for paths with length: 4 for node CREB1_S133 and HSPB1\n", + "looking for paths in the network with length: 0 for node CREB1_S133 and MAPK14\n", + "looking for paths in the network with length: 1 for node CREB1_S133 and MAPK14\n", + "looking for paths in the network with length: 2 for node CREB1_S133 and MAPK14\n", + "looking for paths in the network with length: 3 for node CREB1_S133 and MAPK14\n", + "looking for paths in the network with length: 4 for node CREB1_S133 and MAPK14\n", + "looking for paths in the network with length: 5 for node CREB1_S133 and MAPK14\n", + "looking for paths in the network with length: 6 for node CREB1_S133 and MAPK14\n", + "looking for paths in the network with length: 7 for node CREB1_S133 and MAPK14\n", + "looking for paths in the network with length: 8 for node CREB1_S133 and MAPK14\n", + "looking for paths in the network with length: 9 for node CREB1_S133 and MAPK14\n", + "looking for paths in the network with length: 10 for node CREB1_S133 and MAPK14\n", + "i_search = 4\n", + "Looking for paths with length: 0 for node CREB1_S133 and MAPK14\n", + "i_search = 4\n", + "Looking for paths with length: 1 for node CREB1_S133 and MAPK14\n", + "i_search = 4\n", + "Looking for paths with length: 2 for node CREB1_S133 and MAPK14\n", + "i_search = 4\n", + "Looking for paths with length: 3 for node CREB1_S133 and MAPK14\n", + "i_search = 4\n", + "Looking for paths with length: 4 for node CREB1_S133 and MAPK14\n", + "looking for paths in the network with length: 0 for node CREB1_S133 and MAP2K1\n", + "looking for paths in the network with length: 1 for node CREB1_S133 and MAP2K1\n", + "looking for paths in the network with length: 2 for node CREB1_S133 and MAP2K1\n", + "looking for paths in the network with length: 3 for node CREB1_S133 and MAP2K1\n", + "looking for paths in the network with length: 4 for node CREB1_S133 and MAP2K1\n", + "looking for paths in the network with length: 5 for node CREB1_S133 and MAP2K1\n", + "looking for paths in the network with length: 6 for node CREB1_S133 and MAP2K1\n", + "looking for paths in the network with length: 7 for node CREB1_S133 and MAP2K1\n", + "looking for paths in the network with length: 8 for node CREB1_S133 and MAP2K1\n", + "looking for paths in the network with length: 9 for node CREB1_S133 and MAP2K1\n", + "looking for paths in the network with length: 10 for node CREB1_S133 and MAP2K1\n", + "i_search = 4\n", + "Looking for paths with length: 0 for node CREB1_S133 and MAP2K1\n", + "i_search = 4\n", + "Looking for paths with length: 1 for node CREB1_S133 and MAP2K1\n", + "i_search = 4\n", + "Looking for paths with length: 2 for node CREB1_S133 and MAP2K1\n", + "i_search = 4\n", + "Looking for paths with length: 3 for node CREB1_S133 and MAP2K1\n", + "i_search = 4\n", + "Looking for paths with length: 4 for node CREB1_S133 and MAP2K1\n", + "looking for paths in the network with length: 0 for node CREB1_S133 and RPS6KA1\n", + "looking for paths in the network with length: 1 for node CREB1_S133 and RPS6KA1\n", + "looking for paths in the network with length: 2 for node CREB1_S133 and RPS6KA1\n", + "looking for paths in the network with length: 3 for node CREB1_S133 and RPS6KA1\n", + "looking for paths in the network with length: 4 for node CREB1_S133 and RPS6KA1\n", + "looking for paths in the network with length: 5 for node CREB1_S133 and RPS6KA1\n", + "looking for paths in the network with length: 6 for node CREB1_S133 and RPS6KA1\n", + "looking for paths in the network with length: 7 for node CREB1_S133 and RPS6KA1\n", + "looking for paths in the network with length: 8 for node CREB1_S133 and RPS6KA1\n", + "looking for paths in the network with length: 9 for node CREB1_S133 and RPS6KA1\n", + "looking for paths in the network with length: 10 for node CREB1_S133 and RPS6KA1\n", + "i_search = 4\n", + "Looking for paths with length: 0 for node CREB1_S133 and RPS6KA1\n", + "i_search = 4\n", + "Looking for paths with length: 1 for node CREB1_S133 and RPS6KA1\n", + "i_search = 4\n", + "Looking for paths with length: 2 for node CREB1_S133 and RPS6KA1\n", + "i_search = 4\n", + "Looking for paths with length: 3 for node CREB1_S133 and RPS6KA1\n", + "i_search = 4\n", + "Looking for paths with length: 4 for node CREB1_S133 and RPS6KA1\n", + "looking for paths in the network with length: 0 for node CREB1_S133 and CREB1\n", + "looking for paths in the network with length: 1 for node CREB1_S133 and CREB1\n", + "looking for paths in the network with length: 2 for node CREB1_S133 and CREB1\n", + "looking for paths in the network with length: 3 for node CREB1_S133 and CREB1\n", + "looking for paths in the network with length: 4 for node CREB1_S133 and CREB1\n", + "looking for paths in the network with length: 5 for node CREB1_S133 and CREB1\n", + "looking for paths in the network with length: 6 for node CREB1_S133 and CREB1\n", + "looking for paths in the network with length: 7 for node CREB1_S133 and CREB1\n", + "looking for paths in the network with length: 8 for node CREB1_S133 and CREB1\n", + "looking for paths in the network with length: 9 for node CREB1_S133 and CREB1\n", + "looking for paths in the network with length: 10 for node CREB1_S133 and CREB1\n", + "i_search = 4\n", + "Looking for paths with length: 0 for node CREB1_S133 and CREB1\n", + "i_search = 4\n", + "Looking for paths with length: 1 for node CREB1_S133 and CREB1\n", + "i_search = 4\n", + "Looking for paths with length: 2 for node CREB1_S133 and CREB1\n", + "i_search = 4\n", + "Looking for paths with length: 3 for node CREB1_S133 and CREB1\n", + "i_search = 4\n", + "Looking for paths with length: 4 for node CREB1_S133 and CREB1\n", + "looking for paths in the network with length: 0 for node CREB1_S133 and NFKBIA\n", + "looking for paths in the network with length: 1 for node CREB1_S133 and NFKBIA\n", + "looking for paths in the network with length: 2 for node CREB1_S133 and NFKBIA\n", + "looking for paths in the network with length: 3 for node CREB1_S133 and NFKBIA\n", + "looking for paths in the network with length: 4 for node CREB1_S133 and NFKBIA\n", + "looking for paths in the network with length: 5 for node CREB1_S133 and NFKBIA\n", + "looking for paths in the network with length: 6 for node CREB1_S133 and NFKBIA\n", + "looking for paths in the network with length: 7 for node CREB1_S133 and NFKBIA\n", + "looking for paths in the network with length: 8 for node CREB1_S133 and NFKBIA\n", + "looking for paths in the network with length: 9 for node CREB1_S133 and NFKBIA\n", + "looking for paths in the network with length: 10 for node CREB1_S133 and NFKBIA\n", + "i_search = 4\n", + "Looking for paths with length: 0 for node CREB1_S133 and NFKBIA\n", + "i_search = 4\n", + "Looking for paths with length: 1 for node CREB1_S133 and NFKBIA\n", + "i_search = 4\n", + "Looking for paths with length: 2 for node CREB1_S133 and NFKBIA\n", + "i_search = 4\n", + "Looking for paths with length: 3 for node CREB1_S133 and NFKBIA\n", + "i_search = 4\n", + "Looking for paths with length: 4 for node CREB1_S133 and NFKBIA\n", + "looking for paths in the network with length: 0 for node CREB1_S133 and MTOR\n", + "looking for paths in the network with length: 1 for node CREB1_S133 and MTOR\n", + "looking for paths in the network with length: 2 for node CREB1_S133 and MTOR\n", + "looking for paths in the network with length: 3 for node CREB1_S133 and MTOR\n", + "looking for paths in the network with length: 4 for node CREB1_S133 and MTOR\n", + "looking for paths in the network with length: 5 for node CREB1_S133 and MTOR\n", + "looking for paths in the network with length: 6 for node CREB1_S133 and MTOR\n", + "looking for paths in the network with length: 7 for node CREB1_S133 and MTOR\n", + "looking for paths in the network with length: 8 for node CREB1_S133 and MTOR\n", + "looking for paths in the network with length: 9 for node CREB1_S133 and MTOR\n", + "looking for paths in the network with length: 10 for node CREB1_S133 and MTOR\n", + "i_search = 4\n", + "Looking for paths with length: 0 for node CREB1_S133 and MTOR\n", + "i_search = 4\n", + "Looking for paths with length: 1 for node CREB1_S133 and MTOR\n", + "i_search = 4\n", + "Looking for paths with length: 2 for node CREB1_S133 and MTOR\n", + "i_search = 4\n", + "Looking for paths with length: 3 for node CREB1_S133 and MTOR\n", + "i_search = 4\n", + "Looking for paths with length: 4 for node CREB1_S133 and MTOR\n", + "looking for paths in the network with length: 0 for node CREB1_S133 and JUN\n", + "looking for paths in the network with length: 1 for node CREB1_S133 and JUN\n", + "looking for paths in the network with length: 2 for node CREB1_S133 and JUN\n", + "looking for paths in the network with length: 3 for node CREB1_S133 and JUN\n", + "looking for paths in the network with length: 4 for node CREB1_S133 and JUN\n", + "looking for paths in the network with length: 5 for node CREB1_S133 and JUN\n", + "looking for paths in the network with length: 6 for node CREB1_S133 and JUN\n", + "looking for paths in the network with length: 7 for node CREB1_S133 and JUN\n", + "looking for paths in the network with length: 8 for node CREB1_S133 and JUN\n", + "looking for paths in the network with length: 9 for node CREB1_S133 and JUN\n", + "looking for paths in the network with length: 10 for node CREB1_S133 and JUN\n", + "i_search = 4\n", + "Looking for paths with length: 0 for node CREB1_S133 and JUN\n", + "i_search = 4\n", + "Looking for paths with length: 1 for node CREB1_S133 and JUN\n", + "i_search = 4\n", + "Looking for paths with length: 2 for node CREB1_S133 and JUN\n", + "i_search = 4\n", + "Looking for paths with length: 3 for node CREB1_S133 and JUN\n", + "i_search = 4\n", + "Looking for paths with length: 4 for node CREB1_S133 and JUN\n", + "looking for paths in the network with length: 0 for node CREB1_S133 and EGFR\n", + "looking for paths in the network with length: 1 for node CREB1_S133 and EGFR\n", + "looking for paths in the network with length: 2 for node CREB1_S133 and EGFR\n", + "looking for paths in the network with length: 3 for node CREB1_S133 and EGFR\n", + "looking for paths in the network with length: 4 for node CREB1_S133 and EGFR\n", + "looking for paths in the network with length: 5 for node CREB1_S133 and EGFR\n", + "looking for paths in the network with length: 6 for node CREB1_S133 and EGFR\n", + "looking for paths in the network with length: 7 for node CREB1_S133 and EGFR\n", + "looking for paths in the network with length: 8 for node CREB1_S133 and EGFR\n", + "looking for paths in the network with length: 9 for node CREB1_S133 and EGFR\n", + "looking for paths in the network with length: 10 for node CREB1_S133 and EGFR\n", + "i_search = 4\n", + "Looking for paths with length: 0 for node CREB1_S133 and EGFR\n", + "i_search = 4\n", + "Looking for paths with length: 1 for node CREB1_S133 and EGFR\n", + "i_search = 4\n", + "Looking for paths with length: 2 for node CREB1_S133 and EGFR\n", + "i_search = 4\n", + "Looking for paths with length: 3 for node CREB1_S133 and EGFR\n", + "i_search = 4\n", + "Looking for paths with length: 4 for node CREB1_S133 and EGFR\n", + "looking for paths in the network with length: 0 for node CREB1_S133 and MAPK3\n", + "looking for paths in the network with length: 1 for node CREB1_S133 and MAPK3\n", + "looking for paths in the network with length: 2 for node CREB1_S133 and MAPK3\n", + "looking for paths in the network with length: 3 for node CREB1_S133 and MAPK3\n", + "looking for paths in the network with length: 4 for node CREB1_S133 and MAPK3\n", + "looking for paths in the network with length: 5 for node CREB1_S133 and MAPK3\n", + "looking for paths in the network with length: 6 for node CREB1_S133 and MAPK3\n", + "looking for paths in the network with length: 7 for node CREB1_S133 and MAPK3\n", + "looking for paths in the network with length: 8 for node CREB1_S133 and MAPK3\n", + "looking for paths in the network with length: 9 for node CREB1_S133 and MAPK3\n", + "looking for paths in the network with length: 10 for node CREB1_S133 and MAPK3\n", + "i_search = 4\n", + "Looking for paths with length: 0 for node CREB1_S133 and MAPK3\n", + "i_search = 4\n", + "Looking for paths with length: 1 for node CREB1_S133 and MAPK3\n", + "i_search = 4\n", + "Looking for paths with length: 2 for node CREB1_S133 and MAPK3\n", + "i_search = 4\n", + "Looking for paths with length: 3 for node CREB1_S133 and MAPK3\n", + "i_search = 4\n", + "Looking for paths with length: 4 for node CREB1_S133 and MAPK3\n", + "looking for paths in the network with length: 0 for node CREB1_S133 and PTPN11\n", + "looking for paths in the network with length: 1 for node CREB1_S133 and PTPN11\n", + "looking for paths in the network with length: 2 for node CREB1_S133 and PTPN11\n", + "looking for paths in the network with length: 3 for node CREB1_S133 and PTPN11\n", + "looking for paths in the network with length: 4 for node CREB1_S133 and PTPN11\n", + "looking for paths in the network with length: 5 for node CREB1_S133 and PTPN11\n", + "looking for paths in the network with length: 6 for node CREB1_S133 and PTPN11\n", + "looking for paths in the network with length: 7 for node CREB1_S133 and PTPN11\n", + "looking for paths in the network with length: 8 for node CREB1_S133 and PTPN11\n", + "looking for paths in the network with length: 9 for node CREB1_S133 and PTPN11\n", + "looking for paths in the network with length: 10 for node CREB1_S133 and PTPN11\n", + "i_search = 4\n", + "Looking for paths with length: 0 for node CREB1_S133 and PTPN11\n", + "i_search = 4\n", + "Looking for paths with length: 1 for node CREB1_S133 and PTPN11\n", + "i_search = 4\n", + "Looking for paths with length: 2 for node CREB1_S133 and PTPN11\n", + "i_search = 4\n", + "Looking for paths with length: 3 for node CREB1_S133 and PTPN11\n", + "i_search = 4\n", + "Looking for paths with length: 4 for node CREB1_S133 and PTPN11\n", + "looking for paths in the network with length: 0 for node CREB1_S133 and STAT3\n", + "looking for paths in the network with length: 1 for node CREB1_S133 and STAT3\n", + "looking for paths in the network with length: 2 for node CREB1_S133 and STAT3\n", + "looking for paths in the network with length: 3 for node CREB1_S133 and STAT3\n", + "looking for paths in the network with length: 4 for node CREB1_S133 and STAT3\n", + "looking for paths in the network with length: 5 for node CREB1_S133 and STAT3\n", + "looking for paths in the network with length: 6 for node CREB1_S133 and STAT3\n", + "looking for paths in the network with length: 7 for node CREB1_S133 and STAT3\n", + "looking for paths in the network with length: 8 for node CREB1_S133 and STAT3\n", + "looking for paths in the network with length: 9 for node CREB1_S133 and STAT3\n", + "looking for paths in the network with length: 10 for node CREB1_S133 and STAT3\n", + "i_search = 4\n", + "Looking for paths with length: 0 for node CREB1_S133 and STAT3\n", + "i_search = 4\n", + "Looking for paths with length: 1 for node CREB1_S133 and STAT3\n", + "i_search = 4\n", + "Looking for paths with length: 2 for node CREB1_S133 and STAT3\n", + "i_search = 4\n", + "Looking for paths with length: 3 for node CREB1_S133 and STAT3\n", + "i_search = 4\n", + "Looking for paths with length: 4 for node CREB1_S133 and STAT3\n", + "looking for paths in the network with length: 0 for node CREB1_S133 and CHEK2\n", + "looking for paths in the network with length: 1 for node CREB1_S133 and CHEK2\n", + "looking for paths in the network with length: 2 for node CREB1_S133 and CHEK2\n", + "looking for paths in the network with length: 3 for node CREB1_S133 and CHEK2\n", + "looking for paths in the network with length: 4 for node CREB1_S133 and CHEK2\n", + "looking for paths in the network with length: 5 for node CREB1_S133 and CHEK2\n", + "looking for paths in the network with length: 6 for node CREB1_S133 and CHEK2\n", + "looking for paths in the network with length: 7 for node CREB1_S133 and CHEK2\n", + "looking for paths in the network with length: 8 for node CREB1_S133 and CHEK2\n", + "looking for paths in the network with length: 9 for node CREB1_S133 and CHEK2\n", + "looking for paths in the network with length: 10 for node CREB1_S133 and CHEK2\n", + "i_search = 4\n", + "Looking for paths with length: 0 for node CREB1_S133 and CHEK2\n", + "i_search = 4\n", + "Looking for paths with length: 1 for node CREB1_S133 and CHEK2\n", + "i_search = 4\n", + "Looking for paths with length: 2 for node CREB1_S133 and CHEK2\n", + "i_search = 4\n", + "Looking for paths with length: 3 for node CREB1_S133 and CHEK2\n", + "i_search = 4\n", + "Looking for paths with length: 4 for node CREB1_S133 and CHEK2\n", + "looking for paths in the network with length: 0 for node CREB1_S133 and RELA\n", + "looking for paths in the network with length: 1 for node CREB1_S133 and RELA\n", + "looking for paths in the network with length: 2 for node CREB1_S133 and RELA\n", + "looking for paths in the network with length: 3 for node CREB1_S133 and RELA\n", + "looking for paths in the network with length: 4 for node CREB1_S133 and RELA\n", + "looking for paths in the network with length: 5 for node CREB1_S133 and RELA\n", + "looking for paths in the network with length: 6 for node CREB1_S133 and RELA\n", + "looking for paths in the network with length: 7 for node CREB1_S133 and RELA\n", + "looking for paths in the network with length: 8 for node CREB1_S133 and RELA\n", + "looking for paths in the network with length: 9 for node CREB1_S133 and RELA\n", + "looking for paths in the network with length: 10 for node CREB1_S133 and RELA\n", + "i_search = 4\n", + "Looking for paths with length: 0 for node CREB1_S133 and RELA\n", + "i_search = 4\n", + "Looking for paths with length: 1 for node CREB1_S133 and RELA\n", + "i_search = 4\n", + "Looking for paths with length: 2 for node CREB1_S133 and RELA\n", + "i_search = 4\n", + "Looking for paths with length: 3 for node CREB1_S133 and RELA\n", + "i_search = 4\n", + "Looking for paths with length: 4 for node CREB1_S133 and RELA\n", + "looking for paths in the network with length: 0 for node CREB1_S133 and MARCKS\n", + "looking for paths in the network with length: 1 for node CREB1_S133 and MARCKS\n", + "looking for paths in the network with length: 2 for node CREB1_S133 and MARCKS\n", + "looking for paths in the network with length: 3 for node CREB1_S133 and MARCKS\n", + "looking for paths in the network with length: 4 for node CREB1_S133 and MARCKS\n", + "looking for paths in the network with length: 5 for node CREB1_S133 and MARCKS\n", + "looking for paths in the network with length: 6 for node CREB1_S133 and MARCKS\n", + "looking for paths in the network with length: 7 for node CREB1_S133 and MARCKS\n", + "looking for paths in the network with length: 8 for node CREB1_S133 and MARCKS\n", + "looking for paths in the network with length: 9 for node CREB1_S133 and MARCKS\n", + "looking for paths in the network with length: 10 for node CREB1_S133 and MARCKS\n", + "i_search = 4\n", + "Looking for paths with length: 0 for node CREB1_S133 and MARCKS\n", + "i_search = 4\n", + "Looking for paths with length: 1 for node CREB1_S133 and MARCKS\n", + "i_search = 4\n", + "Looking for paths with length: 2 for node CREB1_S133 and MARCKS\n", + "i_search = 4\n", + "Looking for paths with length: 3 for node CREB1_S133 and MARCKS\n", + "i_search = 4\n", + "Looking for paths with length: 4 for node CREB1_S133 and MARCKS\n", + "looking for paths in the network with length: 0 for node NFKBIA_S32 and NFKBIA_S36\n", + "looking for paths in the network with length: 1 for node NFKBIA_S32 and NFKBIA_S36\n", + "looking for paths in the network with length: 2 for node NFKBIA_S32 and NFKBIA_S36\n", + "looking for paths in the network with length: 3 for node NFKBIA_S32 and NFKBIA_S36\n", + "looking for paths in the network with length: 4 for node NFKBIA_S32 and NFKBIA_S36\n", + "looking for paths in the network with length: 5 for node NFKBIA_S32 and NFKBIA_S36\n", + "looking for paths in the network with length: 6 for node NFKBIA_S32 and NFKBIA_S36\n", + "looking for paths in the network with length: 7 for node NFKBIA_S32 and NFKBIA_S36\n", + "looking for paths in the network with length: 8 for node NFKBIA_S32 and NFKBIA_S36\n", + "looking for paths in the network with length: 9 for node NFKBIA_S32 and NFKBIA_S36\n", + "looking for paths in the network with length: 10 for node NFKBIA_S32 and NFKBIA_S36\n", + "i_search = 4\n", + "Looking for paths with length: 0 for node NFKBIA_S32 and NFKBIA_S36\n", + "i_search = 4\n", + "Looking for paths with length: 1 for node NFKBIA_S32 and NFKBIA_S36\n", + "i_search = 4\n", + "Looking for paths with length: 2 for node NFKBIA_S32 and NFKBIA_S36\n", + "i_search = 4\n", + "Looking for paths with length: 3 for node NFKBIA_S32 and NFKBIA_S36\n", + "i_search = 4\n", + "Looking for paths with length: 4 for node NFKBIA_S32 and NFKBIA_S36\n", + "looking for paths in the network with length: 0 for node NFKBIA_S32 and MTOR_S2448\n", + "looking for paths in the network with length: 1 for node NFKBIA_S32 and MTOR_S2448\n", + "looking for paths in the network with length: 2 for node NFKBIA_S32 and MTOR_S2448\n", + "looking for paths in the network with length: 3 for node NFKBIA_S32 and MTOR_S2448\n", + "looking for paths in the network with length: 4 for node NFKBIA_S32 and MTOR_S2448\n", + "looking for paths in the network with length: 5 for node NFKBIA_S32 and MTOR_S2448\n", + "looking for paths in the network with length: 6 for node NFKBIA_S32 and MTOR_S2448\n", + "looking for paths in the network with length: 7 for node NFKBIA_S32 and MTOR_S2448\n", + "looking for paths in the network with length: 8 for node NFKBIA_S32 and MTOR_S2448\n", + "looking for paths in the network with length: 9 for node NFKBIA_S32 and MTOR_S2448\n", + "looking for paths in the network with length: 10 for node NFKBIA_S32 and MTOR_S2448\n", + "i_search = 4\n", + "Looking for paths with length: 0 for node NFKBIA_S32 and MTOR_S2448\n", + "i_search = 4\n", + "Looking for paths with length: 1 for node NFKBIA_S32 and MTOR_S2448\n", + "i_search = 4\n", + "Looking for paths with length: 2 for node NFKBIA_S32 and MTOR_S2448\n", + "i_search = 4\n", + "Looking for paths with length: 3 for node NFKBIA_S32 and MTOR_S2448\n", + "i_search = 4\n", + "Looking for paths with length: 4 for node NFKBIA_S32 and MTOR_S2448\n", + "[['NFKBIA_S32', 'SGK1', 'SGK1_S422', 'MTOR', 'MTOR_S2448']]\n", + "SGK1 NFKBIA_S32\n", + "SGK1 SGK1_S422\n", + "MTOR SGK1_S422\n", + "MTOR MTOR_S2448\n", + "looking for paths in the network with length: 0 for node NFKBIA_S32 and JUN_S63\n", + "looking for paths in the network with length: 1 for node NFKBIA_S32 and JUN_S63\n", + "looking for paths in the network with length: 2 for node NFKBIA_S32 and JUN_S63\n", + "looking for paths in the network with length: 3 for node NFKBIA_S32 and JUN_S63\n", + "looking for paths in the network with length: 4 for node NFKBIA_S32 and JUN_S63\n", + "looking for paths in the network with length: 5 for node NFKBIA_S32 and JUN_S63\n", + "looking for paths in the network with length: 6 for node NFKBIA_S32 and JUN_S63\n", + "looking for paths in the network with length: 7 for node NFKBIA_S32 and JUN_S63\n", + "looking for paths in the network with length: 8 for node NFKBIA_S32 and JUN_S63\n", + "looking for paths in the network with length: 9 for node NFKBIA_S32 and JUN_S63\n", + "looking for paths in the network with length: 10 for node NFKBIA_S32 and JUN_S63\n", + "i_search = 4\n", + "Looking for paths with length: 0 for node NFKBIA_S32 and JUN_S63\n", + "i_search = 4\n", + "Looking for paths with length: 1 for node NFKBIA_S32 and JUN_S63\n", + "i_search = 4\n", + "Looking for paths with length: 2 for node NFKBIA_S32 and JUN_S63\n", + "i_search = 4\n", + "Looking for paths with length: 3 for node NFKBIA_S32 and JUN_S63\n", + "i_search = 4\n", + "Looking for paths with length: 4 for node NFKBIA_S32 and JUN_S63\n", + "looking for paths in the network with length: 0 for node NFKBIA_S32 and EGFR_Y1068\n", + "looking for paths in the network with length: 1 for node NFKBIA_S32 and EGFR_Y1068\n", + "looking for paths in the network with length: 2 for node NFKBIA_S32 and EGFR_Y1068\n", + "looking for paths in the network with length: 3 for node NFKBIA_S32 and EGFR_Y1068\n", + "looking for paths in the network with length: 4 for node NFKBIA_S32 and EGFR_Y1068\n", + "looking for paths in the network with length: 5 for node NFKBIA_S32 and EGFR_Y1068\n", + "looking for paths in the network with length: 6 for node NFKBIA_S32 and EGFR_Y1068\n", + "looking for paths in the network with length: 7 for node NFKBIA_S32 and EGFR_Y1068\n", + "looking for paths in the network with length: 8 for node NFKBIA_S32 and EGFR_Y1068\n", + "looking for paths in the network with length: 9 for node NFKBIA_S32 and EGFR_Y1068\n", + "looking for paths in the network with length: 10 for node NFKBIA_S32 and EGFR_Y1068\n", + "i_search = 4\n", + "Looking for paths with length: 0 for node NFKBIA_S32 and EGFR_Y1068\n", + "i_search = 4\n", + "Looking for paths with length: 1 for node NFKBIA_S32 and EGFR_Y1068\n", + "i_search = 4\n", + "Looking for paths with length: 2 for node NFKBIA_S32 and EGFR_Y1068\n", + "i_search = 4\n", + "Looking for paths with length: 3 for node NFKBIA_S32 and EGFR_Y1068\n", + "i_search = 4\n", + "Looking for paths with length: 4 for node NFKBIA_S32 and EGFR_Y1068\n", + "looking for paths in the network with length: 0 for node NFKBIA_S32 and MAPK3_T202\n", + "looking for paths in the network with length: 1 for node NFKBIA_S32 and MAPK3_T202\n", + "looking for paths in the network with length: 2 for node NFKBIA_S32 and MAPK3_T202\n", + "looking for paths in the network with length: 3 for node NFKBIA_S32 and MAPK3_T202\n", + "looking for paths in the network with length: 4 for node NFKBIA_S32 and MAPK3_T202\n", + "Found a path!\n", + "[['NFKBIA_S32', 'RPS6KA1', 'RPS6KA1_S380', 'MAPK3', 'MAPK3_T202']]\n", + "looking for paths in the network with length: 0 for node NFKBIA_S32 and MAPK3_Y204\n", + "looking for paths in the network with length: 1 for node NFKBIA_S32 and MAPK3_Y204\n", + "looking for paths in the network with length: 2 for node NFKBIA_S32 and MAPK3_Y204\n", + "looking for paths in the network with length: 3 for node NFKBIA_S32 and MAPK3_Y204\n", + "looking for paths in the network with length: 4 for node NFKBIA_S32 and MAPK3_Y204\n", + "Found a path!\n", + "[['NFKBIA_S32', 'RPS6KA1', 'RPS6KA1_S380', 'MAPK3', 'MAPK3_Y204']]\n", + "looking for paths in the network with length: 0 for node NFKBIA_S32 and PTPN11_Y542\n", + "looking for paths in the network with length: 1 for node NFKBIA_S32 and PTPN11_Y542\n", + "looking for paths in the network with length: 2 for node NFKBIA_S32 and PTPN11_Y542\n", + "looking for paths in the network with length: 3 for node NFKBIA_S32 and PTPN11_Y542\n", + "looking for paths in the network with length: 4 for node NFKBIA_S32 and PTPN11_Y542\n", + "looking for paths in the network with length: 5 for node NFKBIA_S32 and PTPN11_Y542\n", + "looking for paths in the network with length: 6 for node NFKBIA_S32 and PTPN11_Y542\n", + "looking for paths in the network with length: 7 for node NFKBIA_S32 and PTPN11_Y542\n", + "looking for paths in the network with length: 8 for node NFKBIA_S32 and PTPN11_Y542\n", + "looking for paths in the network with length: 9 for node NFKBIA_S32 and PTPN11_Y542\n", + "looking for paths in the network with length: 10 for node NFKBIA_S32 and PTPN11_Y542\n", + "i_search = 4\n", + "Looking for paths with length: 0 for node NFKBIA_S32 and PTPN11_Y542\n", + "i_search = 4\n", + "Looking for paths with length: 1 for node NFKBIA_S32 and PTPN11_Y542\n", + "i_search = 4\n", + "Looking for paths with length: 2 for node NFKBIA_S32 and PTPN11_Y542\n", + "i_search = 4\n", + "Looking for paths with length: 3 for node NFKBIA_S32 and PTPN11_Y542\n", + "i_search = 4\n", + "Looking for paths with length: 4 for node NFKBIA_S32 and PTPN11_Y542\n", + "looking for paths in the network with length: 0 for node NFKBIA_S32 and STAT3_Y705\n", + "looking for paths in the network with length: 1 for node NFKBIA_S32 and STAT3_Y705\n", + "looking for paths in the network with length: 2 for node NFKBIA_S32 and STAT3_Y705\n", + "looking for paths in the network with length: 3 for node NFKBIA_S32 and STAT3_Y705\n", + "looking for paths in the network with length: 4 for node NFKBIA_S32 and STAT3_Y705\n", + "looking for paths in the network with length: 5 for node NFKBIA_S32 and STAT3_Y705\n", + "looking for paths in the network with length: 6 for node NFKBIA_S32 and STAT3_Y705\n", + "looking for paths in the network with length: 7 for node NFKBIA_S32 and STAT3_Y705\n", + "looking for paths in the network with length: 8 for node NFKBIA_S32 and STAT3_Y705\n", + "looking for paths in the network with length: 9 for node NFKBIA_S32 and STAT3_Y705\n", + "looking for paths in the network with length: 10 for node NFKBIA_S32 and STAT3_Y705\n", + "i_search = 4\n", + "Looking for paths with length: 0 for node NFKBIA_S32 and STAT3_Y705\n", + "i_search = 4\n", + "Looking for paths with length: 1 for node NFKBIA_S32 and STAT3_Y705\n", + "i_search = 4\n", + "Looking for paths with length: 2 for node NFKBIA_S32 and STAT3_Y705\n", + "i_search = 4\n", + "Looking for paths with length: 3 for node NFKBIA_S32 and STAT3_Y705\n", + "i_search = 4\n", + "Looking for paths with length: 4 for node NFKBIA_S32 and STAT3_Y705\n", + "looking for paths in the network with length: 0 for node NFKBIA_S32 and CHEK2_T68\n", + "looking for paths in the network with length: 1 for node NFKBIA_S32 and CHEK2_T68\n", + "looking for paths in the network with length: 2 for node NFKBIA_S32 and CHEK2_T68\n", + "looking for paths in the network with length: 3 for node NFKBIA_S32 and CHEK2_T68\n", + "looking for paths in the network with length: 4 for node NFKBIA_S32 and CHEK2_T68\n", + "looking for paths in the network with length: 5 for node NFKBIA_S32 and CHEK2_T68\n", + "looking for paths in the network with length: 6 for node NFKBIA_S32 and CHEK2_T68\n", + "looking for paths in the network with length: 7 for node NFKBIA_S32 and CHEK2_T68\n", + "looking for paths in the network with length: 8 for node NFKBIA_S32 and CHEK2_T68\n", + "looking for paths in the network with length: 9 for node NFKBIA_S32 and CHEK2_T68\n", + "looking for paths in the network with length: 10 for node NFKBIA_S32 and CHEK2_T68\n", + "i_search = 4\n", + "Looking for paths with length: 0 for node NFKBIA_S32 and CHEK2_T68\n", + "i_search = 4\n", + "Looking for paths with length: 1 for node NFKBIA_S32 and CHEK2_T68\n", + "i_search = 4\n", + "Looking for paths with length: 2 for node NFKBIA_S32 and CHEK2_T68\n", + "i_search = 4\n", + "Looking for paths with length: 3 for node NFKBIA_S32 and CHEK2_T68\n", + "i_search = 4\n", + "Looking for paths with length: 4 for node NFKBIA_S32 and CHEK2_T68\n", + "[['NFKBIA_S32', 'AURKB', 'AURKB_S331', 'CHEK2', 'CHEK2_T68']]\n", + "AURKB NFKBIA_S32\n", + "AURKB_S331 AURKB\n", + "CHEK2 AURKB_S331\n", + "CHEK2 CHEK2_T68\n", + "looking for paths in the network with length: 0 for node NFKBIA_S32 and RELA_S536\n", + "looking for paths in the network with length: 1 for node NFKBIA_S32 and RELA_S536\n", + "looking for paths in the network with length: 2 for node NFKBIA_S32 and RELA_S536\n", + "looking for paths in the network with length: 3 for node NFKBIA_S32 and RELA_S536\n", + "looking for paths in the network with length: 4 for node NFKBIA_S32 and RELA_S536\n", + "looking for paths in the network with length: 5 for node NFKBIA_S32 and RELA_S536\n", + "looking for paths in the network with length: 6 for node NFKBIA_S32 and RELA_S536\n", + "looking for paths in the network with length: 7 for node NFKBIA_S32 and RELA_S536\n", + "looking for paths in the network with length: 8 for node NFKBIA_S32 and RELA_S536\n", + "looking for paths in the network with length: 9 for node NFKBIA_S32 and RELA_S536\n", + "looking for paths in the network with length: 10 for node NFKBIA_S32 and RELA_S536\n", + "i_search = 4\n", + "Looking for paths with length: 0 for node NFKBIA_S32 and RELA_S536\n", + "i_search = 4\n", + "Looking for paths with length: 1 for node NFKBIA_S32 and RELA_S536\n", + "i_search = 4\n", + "Looking for paths with length: 2 for node NFKBIA_S32 and RELA_S536\n", + "i_search = 4\n", + "Looking for paths with length: 3 for node NFKBIA_S32 and RELA_S536\n", + "i_search = 4\n", + "Looking for paths with length: 4 for node NFKBIA_S32 and RELA_S536\n", + "looking for paths in the network with length: 0 for node NFKBIA_S32 and MARCKS_S170\n", + "looking for paths in the network with length: 1 for node NFKBIA_S32 and MARCKS_S170\n", + "looking for paths in the network with length: 2 for node NFKBIA_S32 and MARCKS_S170\n", + "looking for paths in the network with length: 3 for node NFKBIA_S32 and MARCKS_S170\n", + "looking for paths in the network with length: 4 for node NFKBIA_S32 and MARCKS_S170\n", + "looking for paths in the network with length: 5 for node NFKBIA_S32 and MARCKS_S170\n", + "looking for paths in the network with length: 6 for node NFKBIA_S32 and MARCKS_S170\n", + "looking for paths in the network with length: 7 for node NFKBIA_S32 and MARCKS_S170\n", + "looking for paths in the network with length: 8 for node NFKBIA_S32 and MARCKS_S170\n", + "looking for paths in the network with length: 9 for node NFKBIA_S32 and MARCKS_S170\n", + "looking for paths in the network with length: 10 for node NFKBIA_S32 and MARCKS_S170\n", + "i_search = 4\n", + "Looking for paths with length: 0 for node NFKBIA_S32 and MARCKS_S170\n", + "i_search = 4\n", + "Looking for paths with length: 1 for node NFKBIA_S32 and MARCKS_S170\n", + "i_search = 4\n", + "Looking for paths with length: 2 for node NFKBIA_S32 and MARCKS_S170\n", + "i_search = 4\n", + "Looking for paths with length: 3 for node NFKBIA_S32 and MARCKS_S170\n", + "i_search = 4\n", + "Looking for paths with length: 4 for node NFKBIA_S32 and MARCKS_S170\n", + "looking for paths in the network with length: 0 for node NFKBIA_S32 and SMAD3\n", + "looking for paths in the network with length: 1 for node NFKBIA_S32 and SMAD3\n", + "looking for paths in the network with length: 2 for node NFKBIA_S32 and SMAD3\n", + "looking for paths in the network with length: 3 for node NFKBIA_S32 and SMAD3\n", + "looking for paths in the network with length: 4 for node NFKBIA_S32 and SMAD3\n", + "looking for paths in the network with length: 5 for node NFKBIA_S32 and SMAD3\n", + "looking for paths in the network with length: 6 for node NFKBIA_S32 and SMAD3\n", + "looking for paths in the network with length: 7 for node NFKBIA_S32 and SMAD3\n", + "looking for paths in the network with length: 8 for node NFKBIA_S32 and SMAD3\n", + "looking for paths in the network with length: 9 for node NFKBIA_S32 and SMAD3\n", + "looking for paths in the network with length: 10 for node NFKBIA_S32 and SMAD3\n", + "i_search = 4\n", + "Looking for paths with length: 0 for node NFKBIA_S32 and SMAD3\n", + "i_search = 4\n", + "Looking for paths with length: 1 for node NFKBIA_S32 and SMAD3\n", + "i_search = 4\n", + "Looking for paths with length: 2 for node NFKBIA_S32 and SMAD3\n", + "i_search = 4\n", + "Looking for paths with length: 3 for node NFKBIA_S32 and SMAD3\n", + "i_search = 4\n", + "Looking for paths with length: 4 for node NFKBIA_S32 and SMAD3\n", + "looking for paths in the network with length: 0 for node NFKBIA_S32 and TP53\n", + "looking for paths in the network with length: 1 for node NFKBIA_S32 and TP53\n", + "looking for paths in the network with length: 2 for node NFKBIA_S32 and TP53\n", + "looking for paths in the network with length: 3 for node NFKBIA_S32 and TP53\n", + "looking for paths in the network with length: 4 for node NFKBIA_S32 and TP53\n", + "looking for paths in the network with length: 5 for node NFKBIA_S32 and TP53\n", + "looking for paths in the network with length: 6 for node NFKBIA_S32 and TP53\n", + "looking for paths in the network with length: 7 for node NFKBIA_S32 and TP53\n", + "looking for paths in the network with length: 8 for node NFKBIA_S32 and TP53\n", + "looking for paths in the network with length: 9 for node NFKBIA_S32 and TP53\n", + "looking for paths in the network with length: 10 for node NFKBIA_S32 and TP53\n", + "i_search = 4\n", + "Looking for paths with length: 0 for node NFKBIA_S32 and TP53\n", + "i_search = 4\n", + "Looking for paths with length: 1 for node NFKBIA_S32 and TP53\n", + "i_search = 4\n", + "Looking for paths with length: 2 for node NFKBIA_S32 and TP53\n", + "i_search = 4\n", + "Looking for paths with length: 3 for node NFKBIA_S32 and TP53\n", + "i_search = 4\n", + "Looking for paths with length: 4 for node NFKBIA_S32 and TP53\n", + "looking for paths in the network with length: 0 for node NFKBIA_S32 and AKT1S1\n", + "looking for paths in the network with length: 1 for node NFKBIA_S32 and AKT1S1\n", + "looking for paths in the network with length: 2 for node NFKBIA_S32 and AKT1S1\n", + "looking for paths in the network with length: 3 for node NFKBIA_S32 and AKT1S1\n", + "looking for paths in the network with length: 4 for node NFKBIA_S32 and AKT1S1\n", + "looking for paths in the network with length: 5 for node NFKBIA_S32 and AKT1S1\n", + "looking for paths in the network with length: 6 for node NFKBIA_S32 and AKT1S1\n", + "looking for paths in the network with length: 7 for node NFKBIA_S32 and AKT1S1\n", + "looking for paths in the network with length: 8 for node NFKBIA_S32 and AKT1S1\n", + "looking for paths in the network with length: 9 for node NFKBIA_S32 and AKT1S1\n", + "looking for paths in the network with length: 10 for node NFKBIA_S32 and AKT1S1\n", + "i_search = 4\n", + "Looking for paths with length: 0 for node NFKBIA_S32 and AKT1S1\n", + "i_search = 4\n", + "Looking for paths with length: 1 for node NFKBIA_S32 and AKT1S1\n", + "i_search = 4\n", + "Looking for paths with length: 2 for node NFKBIA_S32 and AKT1S1\n", + "i_search = 4\n", + "Looking for paths with length: 3 for node NFKBIA_S32 and AKT1S1\n", + "i_search = 4\n", + "Looking for paths with length: 4 for node NFKBIA_S32 and AKT1S1\n", + "looking for paths in the network with length: 0 for node NFKBIA_S32 and GSK3B\n", + "looking for paths in the network with length: 1 for node NFKBIA_S32 and GSK3B\n", + "looking for paths in the network with length: 2 for node NFKBIA_S32 and GSK3B\n", + "looking for paths in the network with length: 3 for node NFKBIA_S32 and GSK3B\n", + "looking for paths in the network with length: 4 for node NFKBIA_S32 and GSK3B\n", + "looking for paths in the network with length: 5 for node NFKBIA_S32 and GSK3B\n", + "looking for paths in the network with length: 6 for node NFKBIA_S32 and GSK3B\n", + "looking for paths in the network with length: 7 for node NFKBIA_S32 and GSK3B\n", + "looking for paths in the network with length: 8 for node NFKBIA_S32 and GSK3B\n", + "looking for paths in the network with length: 9 for node NFKBIA_S32 and GSK3B\n", + "looking for paths in the network with length: 10 for node NFKBIA_S32 and GSK3B\n", + "i_search = 4\n", + "Looking for paths with length: 0 for node NFKBIA_S32 and GSK3B\n", + "i_search = 4\n", + "Looking for paths with length: 1 for node NFKBIA_S32 and GSK3B\n", + "i_search = 4\n", + "Looking for paths with length: 2 for node NFKBIA_S32 and GSK3B\n", + "i_search = 4\n", + "Looking for paths with length: 3 for node NFKBIA_S32 and GSK3B\n", + "i_search = 4\n", + "Looking for paths with length: 4 for node NFKBIA_S32 and GSK3B\n", + "looking for paths in the network with length: 0 for node NFKBIA_S32 and AKT1\n", + "looking for paths in the network with length: 1 for node NFKBIA_S32 and AKT1\n", + "looking for paths in the network with length: 2 for node NFKBIA_S32 and AKT1\n", + "looking for paths in the network with length: 3 for node NFKBIA_S32 and AKT1\n", + "looking for paths in the network with length: 4 for node NFKBIA_S32 and AKT1\n", + "looking for paths in the network with length: 5 for node NFKBIA_S32 and AKT1\n", + "looking for paths in the network with length: 6 for node NFKBIA_S32 and AKT1\n", + "looking for paths in the network with length: 7 for node NFKBIA_S32 and AKT1\n", + "looking for paths in the network with length: 8 for node NFKBIA_S32 and AKT1\n", + "looking for paths in the network with length: 9 for node NFKBIA_S32 and AKT1\n", + "looking for paths in the network with length: 10 for node NFKBIA_S32 and AKT1\n", + "i_search = 4\n", + "Looking for paths with length: 0 for node NFKBIA_S32 and AKT1\n", + "i_search = 4\n", + "Looking for paths with length: 1 for node NFKBIA_S32 and AKT1\n", + "i_search = 4\n", + "Looking for paths with length: 2 for node NFKBIA_S32 and AKT1\n", + "i_search = 4\n", + "Looking for paths with length: 3 for node NFKBIA_S32 and AKT1\n", + "i_search = 4\n", + "Looking for paths with length: 4 for node NFKBIA_S32 and AKT1\n", + "looking for paths in the network with length: 0 for node NFKBIA_S32 and HSPB1\n", + "looking for paths in the network with length: 1 for node NFKBIA_S32 and HSPB1\n", + "looking for paths in the network with length: 2 for node NFKBIA_S32 and HSPB1\n", + "looking for paths in the network with length: 3 for node NFKBIA_S32 and HSPB1\n", + "looking for paths in the network with length: 4 for node NFKBIA_S32 and HSPB1\n", + "looking for paths in the network with length: 5 for node NFKBIA_S32 and HSPB1\n", + "looking for paths in the network with length: 6 for node NFKBIA_S32 and HSPB1\n", + "looking for paths in the network with length: 7 for node NFKBIA_S32 and HSPB1\n", + "looking for paths in the network with length: 8 for node NFKBIA_S32 and HSPB1\n", + "looking for paths in the network with length: 9 for node NFKBIA_S32 and HSPB1\n", + "looking for paths in the network with length: 10 for node NFKBIA_S32 and HSPB1\n", + "i_search = 4\n", + "Looking for paths with length: 0 for node NFKBIA_S32 and HSPB1\n", + "i_search = 4\n", + "Looking for paths with length: 1 for node NFKBIA_S32 and HSPB1\n", + "i_search = 4\n", + "Looking for paths with length: 2 for node NFKBIA_S32 and HSPB1\n", + "i_search = 4\n", + "Looking for paths with length: 3 for node NFKBIA_S32 and HSPB1\n", + "i_search = 4\n", + "Looking for paths with length: 4 for node NFKBIA_S32 and HSPB1\n", + "looking for paths in the network with length: 0 for node NFKBIA_S32 and MAPK14\n", + "looking for paths in the network with length: 1 for node NFKBIA_S32 and MAPK14\n", + "looking for paths in the network with length: 2 for node NFKBIA_S32 and MAPK14\n", + "looking for paths in the network with length: 3 for node NFKBIA_S32 and MAPK14\n", + "looking for paths in the network with length: 4 for node NFKBIA_S32 and MAPK14\n", + "looking for paths in the network with length: 5 for node NFKBIA_S32 and MAPK14\n", + "looking for paths in the network with length: 6 for node NFKBIA_S32 and MAPK14\n", + "looking for paths in the network with length: 7 for node NFKBIA_S32 and MAPK14\n", + "looking for paths in the network with length: 8 for node NFKBIA_S32 and MAPK14\n", + "looking for paths in the network with length: 9 for node NFKBIA_S32 and MAPK14\n", + "looking for paths in the network with length: 10 for node NFKBIA_S32 and MAPK14\n", + "i_search = 4\n", + "Looking for paths with length: 0 for node NFKBIA_S32 and MAPK14\n", + "i_search = 4\n", + "Looking for paths with length: 1 for node NFKBIA_S32 and MAPK14\n", + "i_search = 4\n", + "Looking for paths with length: 2 for node NFKBIA_S32 and MAPK14\n", + "i_search = 4\n", + "Looking for paths with length: 3 for node NFKBIA_S32 and MAPK14\n", + "i_search = 4\n", + "Looking for paths with length: 4 for node NFKBIA_S32 and MAPK14\n", + "looking for paths in the network with length: 0 for node NFKBIA_S32 and MAP2K1\n", + "looking for paths in the network with length: 1 for node NFKBIA_S32 and MAP2K1\n", + "looking for paths in the network with length: 2 for node NFKBIA_S32 and MAP2K1\n", + "looking for paths in the network with length: 3 for node NFKBIA_S32 and MAP2K1\n", + "looking for paths in the network with length: 4 for node NFKBIA_S32 and MAP2K1\n", + "looking for paths in the network with length: 5 for node NFKBIA_S32 and MAP2K1\n", + "looking for paths in the network with length: 6 for node NFKBIA_S32 and MAP2K1\n", + "looking for paths in the network with length: 7 for node NFKBIA_S32 and MAP2K1\n", + "looking for paths in the network with length: 8 for node NFKBIA_S32 and MAP2K1\n", + "looking for paths in the network with length: 9 for node NFKBIA_S32 and MAP2K1\n", + "looking for paths in the network with length: 10 for node NFKBIA_S32 and MAP2K1\n", + "i_search = 4\n", + "Looking for paths with length: 0 for node NFKBIA_S32 and MAP2K1\n", + "i_search = 4\n", + "Looking for paths with length: 1 for node NFKBIA_S32 and MAP2K1\n", + "i_search = 4\n", + "Looking for paths with length: 2 for node NFKBIA_S32 and MAP2K1\n", + "i_search = 4\n", + "Looking for paths with length: 3 for node NFKBIA_S32 and MAP2K1\n", + "i_search = 4\n", + "Looking for paths with length: 4 for node NFKBIA_S32 and MAP2K1\n", + "looking for paths in the network with length: 0 for node NFKBIA_S32 and RPS6KA1\n", + "looking for paths in the network with length: 1 for node NFKBIA_S32 and RPS6KA1\n", + "looking for paths in the network with length: 2 for node NFKBIA_S32 and RPS6KA1\n", + "looking for paths in the network with length: 3 for node NFKBIA_S32 and RPS6KA1\n", + "looking for paths in the network with length: 4 for node NFKBIA_S32 and RPS6KA1\n", + "looking for paths in the network with length: 5 for node NFKBIA_S32 and RPS6KA1\n", + "looking for paths in the network with length: 6 for node NFKBIA_S32 and RPS6KA1\n", + "looking for paths in the network with length: 7 for node NFKBIA_S32 and RPS6KA1\n", + "looking for paths in the network with length: 8 for node NFKBIA_S32 and RPS6KA1\n", + "looking for paths in the network with length: 9 for node NFKBIA_S32 and RPS6KA1\n", + "looking for paths in the network with length: 10 for node NFKBIA_S32 and RPS6KA1\n", + "i_search = 4\n", + "Looking for paths with length: 0 for node NFKBIA_S32 and RPS6KA1\n", + "i_search = 4\n", + "Looking for paths with length: 1 for node NFKBIA_S32 and RPS6KA1\n", + "i_search = 4\n", + "Looking for paths with length: 2 for node NFKBIA_S32 and RPS6KA1\n", + "i_search = 4\n", + "Looking for paths with length: 3 for node NFKBIA_S32 and RPS6KA1\n", + "i_search = 4\n", + "Looking for paths with length: 4 for node NFKBIA_S32 and RPS6KA1\n", + "looking for paths in the network with length: 0 for node NFKBIA_S32 and CREB1\n", + "looking for paths in the network with length: 1 for node NFKBIA_S32 and CREB1\n", + "looking for paths in the network with length: 2 for node NFKBIA_S32 and CREB1\n", + "looking for paths in the network with length: 3 for node NFKBIA_S32 and CREB1\n", + "looking for paths in the network with length: 4 for node NFKBIA_S32 and CREB1\n", + "looking for paths in the network with length: 5 for node NFKBIA_S32 and CREB1\n", + "looking for paths in the network with length: 6 for node NFKBIA_S32 and CREB1\n", + "looking for paths in the network with length: 7 for node NFKBIA_S32 and CREB1\n", + "looking for paths in the network with length: 8 for node NFKBIA_S32 and CREB1\n", + "looking for paths in the network with length: 9 for node NFKBIA_S32 and CREB1\n", + "looking for paths in the network with length: 10 for node NFKBIA_S32 and CREB1\n", + "i_search = 4\n", + "Looking for paths with length: 0 for node NFKBIA_S32 and CREB1\n", + "i_search = 4\n", + "Looking for paths with length: 1 for node NFKBIA_S32 and CREB1\n", + "i_search = 4\n", + "Looking for paths with length: 2 for node NFKBIA_S32 and CREB1\n", + "i_search = 4\n", + "Looking for paths with length: 3 for node NFKBIA_S32 and CREB1\n", + "i_search = 4\n", + "Looking for paths with length: 4 for node NFKBIA_S32 and CREB1\n", + "looking for paths in the network with length: 0 for node NFKBIA_S32 and NFKBIA\n", + "looking for paths in the network with length: 1 for node NFKBIA_S32 and NFKBIA\n", + "looking for paths in the network with length: 2 for node NFKBIA_S32 and NFKBIA\n", + "looking for paths in the network with length: 3 for node NFKBIA_S32 and NFKBIA\n", + "looking for paths in the network with length: 4 for node NFKBIA_S32 and NFKBIA\n", + "looking for paths in the network with length: 5 for node NFKBIA_S32 and NFKBIA\n", + "looking for paths in the network with length: 6 for node NFKBIA_S32 and NFKBIA\n", + "looking for paths in the network with length: 7 for node NFKBIA_S32 and NFKBIA\n", + "looking for paths in the network with length: 8 for node NFKBIA_S32 and NFKBIA\n", + "looking for paths in the network with length: 9 for node NFKBIA_S32 and NFKBIA\n", + "looking for paths in the network with length: 10 for node NFKBIA_S32 and NFKBIA\n", + "i_search = 4\n", + "Looking for paths with length: 0 for node NFKBIA_S32 and NFKBIA\n", + "i_search = 4\n", + "Looking for paths with length: 1 for node NFKBIA_S32 and NFKBIA\n", + "i_search = 4\n", + "Looking for paths with length: 2 for node NFKBIA_S32 and NFKBIA\n", + "i_search = 4\n", + "Looking for paths with length: 3 for node NFKBIA_S32 and NFKBIA\n", + "i_search = 4\n", + "Looking for paths with length: 4 for node NFKBIA_S32 and NFKBIA\n", + "looking for paths in the network with length: 0 for node NFKBIA_S32 and MTOR\n", + "looking for paths in the network with length: 1 for node NFKBIA_S32 and MTOR\n", + "looking for paths in the network with length: 2 for node NFKBIA_S32 and MTOR\n", + "looking for paths in the network with length: 3 for node NFKBIA_S32 and MTOR\n", + "looking for paths in the network with length: 4 for node NFKBIA_S32 and MTOR\n", + "looking for paths in the network with length: 5 for node NFKBIA_S32 and MTOR\n", + "looking for paths in the network with length: 6 for node NFKBIA_S32 and MTOR\n", + "looking for paths in the network with length: 7 for node NFKBIA_S32 and MTOR\n", + "looking for paths in the network with length: 8 for node NFKBIA_S32 and MTOR\n", + "looking for paths in the network with length: 9 for node NFKBIA_S32 and MTOR\n", + "looking for paths in the network with length: 10 for node NFKBIA_S32 and MTOR\n", + "i_search = 4\n", + "Looking for paths with length: 0 for node NFKBIA_S32 and MTOR\n", + "i_search = 4\n", + "Looking for paths with length: 1 for node NFKBIA_S32 and MTOR\n", + "i_search = 4\n", + "Looking for paths with length: 2 for node NFKBIA_S32 and MTOR\n", + "i_search = 4\n", + "Looking for paths with length: 3 for node NFKBIA_S32 and MTOR\n", + "i_search = 4\n", + "Looking for paths with length: 4 for node NFKBIA_S32 and MTOR\n", + "looking for paths in the network with length: 0 for node NFKBIA_S32 and JUN\n", + "looking for paths in the network with length: 1 for node NFKBIA_S32 and JUN\n", + "looking for paths in the network with length: 2 for node NFKBIA_S32 and JUN\n", + "looking for paths in the network with length: 3 for node NFKBIA_S32 and JUN\n", + "looking for paths in the network with length: 4 for node NFKBIA_S32 and JUN\n", + "looking for paths in the network with length: 5 for node NFKBIA_S32 and JUN\n", + "looking for paths in the network with length: 6 for node NFKBIA_S32 and JUN\n", + "looking for paths in the network with length: 7 for node NFKBIA_S32 and JUN\n", + "looking for paths in the network with length: 8 for node NFKBIA_S32 and JUN\n", + "looking for paths in the network with length: 9 for node NFKBIA_S32 and JUN\n", + "looking for paths in the network with length: 10 for node NFKBIA_S32 and JUN\n", + "i_search = 4\n", + "Looking for paths with length: 0 for node NFKBIA_S32 and JUN\n", + "i_search = 4\n", + "Looking for paths with length: 1 for node NFKBIA_S32 and JUN\n", + "i_search = 4\n", + "Looking for paths with length: 2 for node NFKBIA_S32 and JUN\n", + "i_search = 4\n", + "Looking for paths with length: 3 for node NFKBIA_S32 and JUN\n", + "i_search = 4\n", + "Looking for paths with length: 4 for node NFKBIA_S32 and JUN\n", + "looking for paths in the network with length: 0 for node NFKBIA_S32 and EGFR\n", + "looking for paths in the network with length: 1 for node NFKBIA_S32 and EGFR\n", + "looking for paths in the network with length: 2 for node NFKBIA_S32 and EGFR\n", + "looking for paths in the network with length: 3 for node NFKBIA_S32 and EGFR\n", + "looking for paths in the network with length: 4 for node NFKBIA_S32 and EGFR\n", + "looking for paths in the network with length: 5 for node NFKBIA_S32 and EGFR\n", + "looking for paths in the network with length: 6 for node NFKBIA_S32 and EGFR\n", + "looking for paths in the network with length: 7 for node NFKBIA_S32 and EGFR\n", + "looking for paths in the network with length: 8 for node NFKBIA_S32 and EGFR\n", + "looking for paths in the network with length: 9 for node NFKBIA_S32 and EGFR\n", + "looking for paths in the network with length: 10 for node NFKBIA_S32 and EGFR\n", + "i_search = 4\n", + "Looking for paths with length: 0 for node NFKBIA_S32 and EGFR\n", + "i_search = 4\n", + "Looking for paths with length: 1 for node NFKBIA_S32 and EGFR\n", + "i_search = 4\n", + "Looking for paths with length: 2 for node NFKBIA_S32 and EGFR\n", + "i_search = 4\n", + "Looking for paths with length: 3 for node NFKBIA_S32 and EGFR\n", + "i_search = 4\n", + "Looking for paths with length: 4 for node NFKBIA_S32 and EGFR\n", + "looking for paths in the network with length: 0 for node NFKBIA_S32 and MAPK3\n", + "looking for paths in the network with length: 1 for node NFKBIA_S32 and MAPK3\n", + "looking for paths in the network with length: 2 for node NFKBIA_S32 and MAPK3\n", + "looking for paths in the network with length: 3 for node NFKBIA_S32 and MAPK3\n", + "looking for paths in the network with length: 4 for node NFKBIA_S32 and MAPK3\n", + "looking for paths in the network with length: 5 for node NFKBIA_S32 and MAPK3\n", + "looking for paths in the network with length: 6 for node NFKBIA_S32 and MAPK3\n", + "looking for paths in the network with length: 7 for node NFKBIA_S32 and MAPK3\n", + "looking for paths in the network with length: 8 for node NFKBIA_S32 and MAPK3\n", + "looking for paths in the network with length: 9 for node NFKBIA_S32 and MAPK3\n", + "looking for paths in the network with length: 10 for node NFKBIA_S32 and MAPK3\n", + "i_search = 4\n", + "Looking for paths with length: 0 for node NFKBIA_S32 and MAPK3\n", + "i_search = 4\n", + "Looking for paths with length: 1 for node NFKBIA_S32 and MAPK3\n", + "i_search = 4\n", + "Looking for paths with length: 2 for node NFKBIA_S32 and MAPK3\n", + "i_search = 4\n", + "Looking for paths with length: 3 for node NFKBIA_S32 and MAPK3\n", + "i_search = 4\n", + "Looking for paths with length: 4 for node NFKBIA_S32 and MAPK3\n", + "looking for paths in the network with length: 0 for node NFKBIA_S32 and PTPN11\n", + "looking for paths in the network with length: 1 for node NFKBIA_S32 and PTPN11\n", + "looking for paths in the network with length: 2 for node NFKBIA_S32 and PTPN11\n", + "looking for paths in the network with length: 3 for node NFKBIA_S32 and PTPN11\n", + "looking for paths in the network with length: 4 for node NFKBIA_S32 and PTPN11\n", + "looking for paths in the network with length: 5 for node NFKBIA_S32 and PTPN11\n", + "looking for paths in the network with length: 6 for node NFKBIA_S32 and PTPN11\n", + "looking for paths in the network with length: 7 for node NFKBIA_S32 and PTPN11\n", + "looking for paths in the network with length: 8 for node NFKBIA_S32 and PTPN11\n", + "looking for paths in the network with length: 9 for node NFKBIA_S32 and PTPN11\n", + "looking for paths in the network with length: 10 for node NFKBIA_S32 and PTPN11\n", + "i_search = 4\n", + "Looking for paths with length: 0 for node NFKBIA_S32 and PTPN11\n", + "i_search = 4\n", + "Looking for paths with length: 1 for node NFKBIA_S32 and PTPN11\n", + "i_search = 4\n", + "Looking for paths with length: 2 for node NFKBIA_S32 and PTPN11\n", + "i_search = 4\n", + "Looking for paths with length: 3 for node NFKBIA_S32 and PTPN11\n", + "i_search = 4\n", + "Looking for paths with length: 4 for node NFKBIA_S32 and PTPN11\n", + "looking for paths in the network with length: 0 for node NFKBIA_S32 and STAT3\n", + "looking for paths in the network with length: 1 for node NFKBIA_S32 and STAT3\n", + "looking for paths in the network with length: 2 for node NFKBIA_S32 and STAT3\n", + "looking for paths in the network with length: 3 for node NFKBIA_S32 and STAT3\n", + "looking for paths in the network with length: 4 for node NFKBIA_S32 and STAT3\n", + "looking for paths in the network with length: 5 for node NFKBIA_S32 and STAT3\n", + "looking for paths in the network with length: 6 for node NFKBIA_S32 and STAT3\n", + "looking for paths in the network with length: 7 for node NFKBIA_S32 and STAT3\n", + "looking for paths in the network with length: 8 for node NFKBIA_S32 and STAT3\n", + "looking for paths in the network with length: 9 for node NFKBIA_S32 and STAT3\n", + "looking for paths in the network with length: 10 for node NFKBIA_S32 and STAT3\n", + "i_search = 4\n", + "Looking for paths with length: 0 for node NFKBIA_S32 and STAT3\n", + "i_search = 4\n", + "Looking for paths with length: 1 for node NFKBIA_S32 and STAT3\n", + "i_search = 4\n", + "Looking for paths with length: 2 for node NFKBIA_S32 and STAT3\n", + "i_search = 4\n", + "Looking for paths with length: 3 for node NFKBIA_S32 and STAT3\n", + "i_search = 4\n", + "Looking for paths with length: 4 for node NFKBIA_S32 and STAT3\n", + "looking for paths in the network with length: 0 for node NFKBIA_S32 and CHEK2\n", + "looking for paths in the network with length: 1 for node NFKBIA_S32 and CHEK2\n", + "looking for paths in the network with length: 2 for node NFKBIA_S32 and CHEK2\n", + "looking for paths in the network with length: 3 for node NFKBIA_S32 and CHEK2\n", + "looking for paths in the network with length: 4 for node NFKBIA_S32 and CHEK2\n", + "looking for paths in the network with length: 5 for node NFKBIA_S32 and CHEK2\n", + "looking for paths in the network with length: 6 for node NFKBIA_S32 and CHEK2\n", + "looking for paths in the network with length: 7 for node NFKBIA_S32 and CHEK2\n", + "looking for paths in the network with length: 8 for node NFKBIA_S32 and CHEK2\n", + "looking for paths in the network with length: 9 for node NFKBIA_S32 and CHEK2\n", + "looking for paths in the network with length: 10 for node NFKBIA_S32 and CHEK2\n", + "i_search = 4\n", + "Looking for paths with length: 0 for node NFKBIA_S32 and CHEK2\n", + "i_search = 4\n", + "Looking for paths with length: 1 for node NFKBIA_S32 and CHEK2\n", + "i_search = 4\n", + "Looking for paths with length: 2 for node NFKBIA_S32 and CHEK2\n", + "i_search = 4\n", + "Looking for paths with length: 3 for node NFKBIA_S32 and CHEK2\n", + "i_search = 4\n", + "Looking for paths with length: 4 for node NFKBIA_S32 and CHEK2\n", + "looking for paths in the network with length: 0 for node NFKBIA_S32 and RELA\n", + "looking for paths in the network with length: 1 for node NFKBIA_S32 and RELA\n", + "looking for paths in the network with length: 2 for node NFKBIA_S32 and RELA\n", + "looking for paths in the network with length: 3 for node NFKBIA_S32 and RELA\n", + "looking for paths in the network with length: 4 for node NFKBIA_S32 and RELA\n", + "looking for paths in the network with length: 5 for node NFKBIA_S32 and RELA\n", + "looking for paths in the network with length: 6 for node NFKBIA_S32 and RELA\n", + "looking for paths in the network with length: 7 for node NFKBIA_S32 and RELA\n", + "looking for paths in the network with length: 8 for node NFKBIA_S32 and RELA\n", + "looking for paths in the network with length: 9 for node NFKBIA_S32 and RELA\n", + "looking for paths in the network with length: 10 for node NFKBIA_S32 and RELA\n", + "i_search = 4\n", + "Looking for paths with length: 0 for node NFKBIA_S32 and RELA\n", + "i_search = 4\n", + "Looking for paths with length: 1 for node NFKBIA_S32 and RELA\n", + "i_search = 4\n", + "Looking for paths with length: 2 for node NFKBIA_S32 and RELA\n", + "i_search = 4\n", + "Looking for paths with length: 3 for node NFKBIA_S32 and RELA\n", + "i_search = 4\n", + "Looking for paths with length: 4 for node NFKBIA_S32 and RELA\n", + "looking for paths in the network with length: 0 for node NFKBIA_S32 and MARCKS\n", + "looking for paths in the network with length: 1 for node NFKBIA_S32 and MARCKS\n", + "looking for paths in the network with length: 2 for node NFKBIA_S32 and MARCKS\n", + "looking for paths in the network with length: 3 for node NFKBIA_S32 and MARCKS\n", + "looking for paths in the network with length: 4 for node NFKBIA_S32 and MARCKS\n", + "looking for paths in the network with length: 5 for node NFKBIA_S32 and MARCKS\n", + "looking for paths in the network with length: 6 for node NFKBIA_S32 and MARCKS\n", + "looking for paths in the network with length: 7 for node NFKBIA_S32 and MARCKS\n", + "looking for paths in the network with length: 8 for node NFKBIA_S32 and MARCKS\n", + "looking for paths in the network with length: 9 for node NFKBIA_S32 and MARCKS\n", + "looking for paths in the network with length: 10 for node NFKBIA_S32 and MARCKS\n", + "i_search = 4\n", + "Looking for paths with length: 0 for node NFKBIA_S32 and MARCKS\n", + "i_search = 4\n", + "Looking for paths with length: 1 for node NFKBIA_S32 and MARCKS\n", + "i_search = 4\n", + "Looking for paths with length: 2 for node NFKBIA_S32 and MARCKS\n", + "i_search = 4\n", + "Looking for paths with length: 3 for node NFKBIA_S32 and MARCKS\n", + "i_search = 4\n", + "Looking for paths with length: 4 for node NFKBIA_S32 and MARCKS\n", + "looking for paths in the network with length: 0 for node NFKBIA_S36 and MTOR_S2448\n", + "looking for paths in the network with length: 1 for node NFKBIA_S36 and MTOR_S2448\n", + "looking for paths in the network with length: 2 for node NFKBIA_S36 and MTOR_S2448\n", + "looking for paths in the network with length: 3 for node NFKBIA_S36 and MTOR_S2448\n", + "looking for paths in the network with length: 4 for node NFKBIA_S36 and MTOR_S2448\n", + "looking for paths in the network with length: 5 for node NFKBIA_S36 and MTOR_S2448\n", + "looking for paths in the network with length: 6 for node NFKBIA_S36 and MTOR_S2448\n", + "looking for paths in the network with length: 7 for node NFKBIA_S36 and MTOR_S2448\n", + "looking for paths in the network with length: 8 for node NFKBIA_S36 and MTOR_S2448\n", + "looking for paths in the network with length: 9 for node NFKBIA_S36 and MTOR_S2448\n", + "looking for paths in the network with length: 10 for node NFKBIA_S36 and MTOR_S2448\n", + "i_search = 4\n", + "Looking for paths with length: 0 for node NFKBIA_S36 and MTOR_S2448\n", + "i_search = 4\n", + "Looking for paths with length: 1 for node NFKBIA_S36 and MTOR_S2448\n", + "i_search = 4\n", + "Looking for paths with length: 2 for node NFKBIA_S36 and MTOR_S2448\n", + "i_search = 4\n", + "Looking for paths with length: 3 for node NFKBIA_S36 and MTOR_S2448\n", + "i_search = 4\n", + "Looking for paths with length: 4 for node NFKBIA_S36 and MTOR_S2448\n", + "looking for paths in the network with length: 0 for node NFKBIA_S36 and JUN_S63\n", + "looking for paths in the network with length: 1 for node NFKBIA_S36 and JUN_S63\n", + "looking for paths in the network with length: 2 for node NFKBIA_S36 and JUN_S63\n", + "looking for paths in the network with length: 3 for node NFKBIA_S36 and JUN_S63\n", + "looking for paths in the network with length: 4 for node NFKBIA_S36 and JUN_S63\n", + "looking for paths in the network with length: 5 for node NFKBIA_S36 and JUN_S63\n", + "looking for paths in the network with length: 6 for node NFKBIA_S36 and JUN_S63\n", + "looking for paths in the network with length: 7 for node NFKBIA_S36 and JUN_S63\n", + "looking for paths in the network with length: 8 for node NFKBIA_S36 and JUN_S63\n", + "looking for paths in the network with length: 9 for node NFKBIA_S36 and JUN_S63\n", + "looking for paths in the network with length: 10 for node NFKBIA_S36 and JUN_S63\n", + "i_search = 4\n", + "Looking for paths with length: 0 for node NFKBIA_S36 and JUN_S63\n", + "i_search = 4\n", + "Looking for paths with length: 1 for node NFKBIA_S36 and JUN_S63\n", + "i_search = 4\n", + "Looking for paths with length: 2 for node NFKBIA_S36 and JUN_S63\n", + "i_search = 4\n", + "Looking for paths with length: 3 for node NFKBIA_S36 and JUN_S63\n", + "i_search = 4\n", + "Looking for paths with length: 4 for node NFKBIA_S36 and JUN_S63\n", + "looking for paths in the network with length: 0 for node NFKBIA_S36 and EGFR_Y1068\n", + "looking for paths in the network with length: 1 for node NFKBIA_S36 and EGFR_Y1068\n", + "looking for paths in the network with length: 2 for node NFKBIA_S36 and EGFR_Y1068\n", + "looking for paths in the network with length: 3 for node NFKBIA_S36 and EGFR_Y1068\n", + "looking for paths in the network with length: 4 for node NFKBIA_S36 and EGFR_Y1068\n", + "looking for paths in the network with length: 5 for node NFKBIA_S36 and EGFR_Y1068\n", + "looking for paths in the network with length: 6 for node NFKBIA_S36 and EGFR_Y1068\n", + "looking for paths in the network with length: 7 for node NFKBIA_S36 and EGFR_Y1068\n", + "looking for paths in the network with length: 8 for node NFKBIA_S36 and EGFR_Y1068\n", + "looking for paths in the network with length: 9 for node NFKBIA_S36 and EGFR_Y1068\n", + "looking for paths in the network with length: 10 for node NFKBIA_S36 and EGFR_Y1068\n", + "i_search = 4\n", + "Looking for paths with length: 0 for node NFKBIA_S36 and EGFR_Y1068\n", + "i_search = 4\n", + "Looking for paths with length: 1 for node NFKBIA_S36 and EGFR_Y1068\n", + "i_search = 4\n", + "Looking for paths with length: 2 for node NFKBIA_S36 and EGFR_Y1068\n", + "i_search = 4\n", + "Looking for paths with length: 3 for node NFKBIA_S36 and EGFR_Y1068\n", + "i_search = 4\n", + "Looking for paths with length: 4 for node NFKBIA_S36 and EGFR_Y1068\n", + "looking for paths in the network with length: 0 for node NFKBIA_S36 and MAPK3_T202\n", + "looking for paths in the network with length: 1 for node NFKBIA_S36 and MAPK3_T202\n", + "looking for paths in the network with length: 2 for node NFKBIA_S36 and MAPK3_T202\n", + "looking for paths in the network with length: 3 for node NFKBIA_S36 and MAPK3_T202\n", + "looking for paths in the network with length: 4 for node NFKBIA_S36 and MAPK3_T202\n", + "looking for paths in the network with length: 5 for node NFKBIA_S36 and MAPK3_T202\n", + "looking for paths in the network with length: 6 for node NFKBIA_S36 and MAPK3_T202\n", + "looking for paths in the network with length: 7 for node NFKBIA_S36 and MAPK3_T202\n", + "looking for paths in the network with length: 8 for node NFKBIA_S36 and MAPK3_T202\n", + "looking for paths in the network with length: 9 for node NFKBIA_S36 and MAPK3_T202\n", + "looking for paths in the network with length: 10 for node NFKBIA_S36 and MAPK3_T202\n", + "i_search = 4\n", + "Looking for paths with length: 0 for node NFKBIA_S36 and MAPK3_T202\n", + "i_search = 4\n", + "Looking for paths with length: 1 for node NFKBIA_S36 and MAPK3_T202\n", + "i_search = 4\n", + "Looking for paths with length: 2 for node NFKBIA_S36 and MAPK3_T202\n", + "i_search = 4\n", + "Looking for paths with length: 3 for node NFKBIA_S36 and MAPK3_T202\n", + "i_search = 4\n", + "Looking for paths with length: 4 for node NFKBIA_S36 and MAPK3_T202\n", + "looking for paths in the network with length: 0 for node NFKBIA_S36 and MAPK3_Y204\n", + "looking for paths in the network with length: 1 for node NFKBIA_S36 and MAPK3_Y204\n", + "looking for paths in the network with length: 2 for node NFKBIA_S36 and MAPK3_Y204\n", + "looking for paths in the network with length: 3 for node NFKBIA_S36 and MAPK3_Y204\n", + "looking for paths in the network with length: 4 for node NFKBIA_S36 and MAPK3_Y204\n", + "looking for paths in the network with length: 5 for node NFKBIA_S36 and MAPK3_Y204\n", + "looking for paths in the network with length: 6 for node NFKBIA_S36 and MAPK3_Y204\n", + "looking for paths in the network with length: 7 for node NFKBIA_S36 and MAPK3_Y204\n", + "looking for paths in the network with length: 8 for node NFKBIA_S36 and MAPK3_Y204\n", + "looking for paths in the network with length: 9 for node NFKBIA_S36 and MAPK3_Y204\n", + "looking for paths in the network with length: 10 for node NFKBIA_S36 and MAPK3_Y204\n", + "i_search = 4\n", + "Looking for paths with length: 0 for node NFKBIA_S36 and MAPK3_Y204\n", + "i_search = 4\n", + "Looking for paths with length: 1 for node NFKBIA_S36 and MAPK3_Y204\n", + "i_search = 4\n", + "Looking for paths with length: 2 for node NFKBIA_S36 and MAPK3_Y204\n", + "i_search = 4\n", + "Looking for paths with length: 3 for node NFKBIA_S36 and MAPK3_Y204\n", + "i_search = 4\n", + "Looking for paths with length: 4 for node NFKBIA_S36 and MAPK3_Y204\n", + "looking for paths in the network with length: 0 for node NFKBIA_S36 and PTPN11_Y542\n", + "looking for paths in the network with length: 1 for node NFKBIA_S36 and PTPN11_Y542\n", + "looking for paths in the network with length: 2 for node NFKBIA_S36 and PTPN11_Y542\n", + "looking for paths in the network with length: 3 for node NFKBIA_S36 and PTPN11_Y542\n", + "looking for paths in the network with length: 4 for node NFKBIA_S36 and PTPN11_Y542\n", + "looking for paths in the network with length: 5 for node NFKBIA_S36 and PTPN11_Y542\n", + "looking for paths in the network with length: 6 for node NFKBIA_S36 and PTPN11_Y542\n", + "looking for paths in the network with length: 7 for node NFKBIA_S36 and PTPN11_Y542\n", + "looking for paths in the network with length: 8 for node NFKBIA_S36 and PTPN11_Y542\n", + "looking for paths in the network with length: 9 for node NFKBIA_S36 and PTPN11_Y542\n", + "looking for paths in the network with length: 10 for node NFKBIA_S36 and PTPN11_Y542\n", + "i_search = 4\n", + "Looking for paths with length: 0 for node NFKBIA_S36 and PTPN11_Y542\n", + "i_search = 4\n", + "Looking for paths with length: 1 for node NFKBIA_S36 and PTPN11_Y542\n", + "i_search = 4\n", + "Looking for paths with length: 2 for node NFKBIA_S36 and PTPN11_Y542\n", + "i_search = 4\n", + "Looking for paths with length: 3 for node NFKBIA_S36 and PTPN11_Y542\n", + "i_search = 4\n", + "Looking for paths with length: 4 for node NFKBIA_S36 and PTPN11_Y542\n", + "looking for paths in the network with length: 0 for node NFKBIA_S36 and STAT3_Y705\n", + "looking for paths in the network with length: 1 for node NFKBIA_S36 and STAT3_Y705\n", + "looking for paths in the network with length: 2 for node NFKBIA_S36 and STAT3_Y705\n", + "looking for paths in the network with length: 3 for node NFKBIA_S36 and STAT3_Y705\n", + "looking for paths in the network with length: 4 for node NFKBIA_S36 and STAT3_Y705\n", + "looking for paths in the network with length: 5 for node NFKBIA_S36 and STAT3_Y705\n", + "looking for paths in the network with length: 6 for node NFKBIA_S36 and STAT3_Y705\n", + "looking for paths in the network with length: 7 for node NFKBIA_S36 and STAT3_Y705\n", + "looking for paths in the network with length: 8 for node NFKBIA_S36 and STAT3_Y705\n", + "looking for paths in the network with length: 9 for node NFKBIA_S36 and STAT3_Y705\n", + "looking for paths in the network with length: 10 for node NFKBIA_S36 and STAT3_Y705\n", + "i_search = 4\n", + "Looking for paths with length: 0 for node NFKBIA_S36 and STAT3_Y705\n", + "i_search = 4\n", + "Looking for paths with length: 1 for node NFKBIA_S36 and STAT3_Y705\n", + "i_search = 4\n", + "Looking for paths with length: 2 for node NFKBIA_S36 and STAT3_Y705\n", + "i_search = 4\n", + "Looking for paths with length: 3 for node NFKBIA_S36 and STAT3_Y705\n", + "i_search = 4\n", + "Looking for paths with length: 4 for node NFKBIA_S36 and STAT3_Y705\n", + "looking for paths in the network with length: 0 for node NFKBIA_S36 and CHEK2_T68\n", + "looking for paths in the network with length: 1 for node NFKBIA_S36 and CHEK2_T68\n", + "looking for paths in the network with length: 2 for node NFKBIA_S36 and CHEK2_T68\n", + "looking for paths in the network with length: 3 for node NFKBIA_S36 and CHEK2_T68\n", + "looking for paths in the network with length: 4 for node NFKBIA_S36 and CHEK2_T68\n", + "looking for paths in the network with length: 5 for node NFKBIA_S36 and CHEK2_T68\n", + "looking for paths in the network with length: 6 for node NFKBIA_S36 and CHEK2_T68\n", + "looking for paths in the network with length: 7 for node NFKBIA_S36 and CHEK2_T68\n", + "looking for paths in the network with length: 8 for node NFKBIA_S36 and CHEK2_T68\n", + "looking for paths in the network with length: 9 for node NFKBIA_S36 and CHEK2_T68\n", + "looking for paths in the network with length: 10 for node NFKBIA_S36 and CHEK2_T68\n", + "i_search = 4\n", + "Looking for paths with length: 0 for node NFKBIA_S36 and CHEK2_T68\n", + "i_search = 4\n", + "Looking for paths with length: 1 for node NFKBIA_S36 and CHEK2_T68\n", + "i_search = 4\n", + "Looking for paths with length: 2 for node NFKBIA_S36 and CHEK2_T68\n", + "i_search = 4\n", + "Looking for paths with length: 3 for node NFKBIA_S36 and CHEK2_T68\n", + "i_search = 4\n", + "Looking for paths with length: 4 for node NFKBIA_S36 and CHEK2_T68\n", + "looking for paths in the network with length: 0 for node NFKBIA_S36 and RELA_S536\n", + "looking for paths in the network with length: 1 for node NFKBIA_S36 and RELA_S536\n", + "looking for paths in the network with length: 2 for node NFKBIA_S36 and RELA_S536\n", + "looking for paths in the network with length: 3 for node NFKBIA_S36 and RELA_S536\n", + "looking for paths in the network with length: 4 for node NFKBIA_S36 and RELA_S536\n", + "looking for paths in the network with length: 5 for node NFKBIA_S36 and RELA_S536\n", + "looking for paths in the network with length: 6 for node NFKBIA_S36 and RELA_S536\n", + "looking for paths in the network with length: 7 for node NFKBIA_S36 and RELA_S536\n", + "looking for paths in the network with length: 8 for node NFKBIA_S36 and RELA_S536\n", + "looking for paths in the network with length: 9 for node NFKBIA_S36 and RELA_S536\n", + "looking for paths in the network with length: 10 for node NFKBIA_S36 and RELA_S536\n", + "i_search = 4\n", + "Looking for paths with length: 0 for node NFKBIA_S36 and RELA_S536\n", + "i_search = 4\n", + "Looking for paths with length: 1 for node NFKBIA_S36 and RELA_S536\n", + "i_search = 4\n", + "Looking for paths with length: 2 for node NFKBIA_S36 and RELA_S536\n", + "i_search = 4\n", + "Looking for paths with length: 3 for node NFKBIA_S36 and RELA_S536\n", + "i_search = 4\n", + "Looking for paths with length: 4 for node NFKBIA_S36 and RELA_S536\n", + "looking for paths in the network with length: 0 for node NFKBIA_S36 and MARCKS_S170\n", + "looking for paths in the network with length: 1 for node NFKBIA_S36 and MARCKS_S170\n", + "looking for paths in the network with length: 2 for node NFKBIA_S36 and MARCKS_S170\n", + "looking for paths in the network with length: 3 for node NFKBIA_S36 and MARCKS_S170\n", + "looking for paths in the network with length: 4 for node NFKBIA_S36 and MARCKS_S170\n", + "looking for paths in the network with length: 5 for node NFKBIA_S36 and MARCKS_S170\n", + "looking for paths in the network with length: 6 for node NFKBIA_S36 and MARCKS_S170\n", + "looking for paths in the network with length: 7 for node NFKBIA_S36 and MARCKS_S170\n", + "looking for paths in the network with length: 8 for node NFKBIA_S36 and MARCKS_S170\n", + "looking for paths in the network with length: 9 for node NFKBIA_S36 and MARCKS_S170\n", + "looking for paths in the network with length: 10 for node NFKBIA_S36 and MARCKS_S170\n", + "i_search = 4\n", + "Looking for paths with length: 0 for node NFKBIA_S36 and MARCKS_S170\n", + "i_search = 4\n", + "Looking for paths with length: 1 for node NFKBIA_S36 and MARCKS_S170\n", + "i_search = 4\n", + "Looking for paths with length: 2 for node NFKBIA_S36 and MARCKS_S170\n", + "i_search = 4\n", + "Looking for paths with length: 3 for node NFKBIA_S36 and MARCKS_S170\n", + "i_search = 4\n", + "Looking for paths with length: 4 for node NFKBIA_S36 and MARCKS_S170\n", + "looking for paths in the network with length: 0 for node NFKBIA_S36 and SMAD3\n", + "looking for paths in the network with length: 1 for node NFKBIA_S36 and SMAD3\n", + "looking for paths in the network with length: 2 for node NFKBIA_S36 and SMAD3\n", + "looking for paths in the network with length: 3 for node NFKBIA_S36 and SMAD3\n", + "looking for paths in the network with length: 4 for node NFKBIA_S36 and SMAD3\n", + "looking for paths in the network with length: 5 for node NFKBIA_S36 and SMAD3\n", + "looking for paths in the network with length: 6 for node NFKBIA_S36 and SMAD3\n", + "looking for paths in the network with length: 7 for node NFKBIA_S36 and SMAD3\n", + "looking for paths in the network with length: 8 for node NFKBIA_S36 and SMAD3\n", + "looking for paths in the network with length: 9 for node NFKBIA_S36 and SMAD3\n", + "looking for paths in the network with length: 10 for node NFKBIA_S36 and SMAD3\n", + "i_search = 4\n", + "Looking for paths with length: 0 for node NFKBIA_S36 and SMAD3\n", + "i_search = 4\n", + "Looking for paths with length: 1 for node NFKBIA_S36 and SMAD3\n", + "i_search = 4\n", + "Looking for paths with length: 2 for node NFKBIA_S36 and SMAD3\n", + "i_search = 4\n", + "Looking for paths with length: 3 for node NFKBIA_S36 and SMAD3\n", + "i_search = 4\n", + "Looking for paths with length: 4 for node NFKBIA_S36 and SMAD3\n", + "looking for paths in the network with length: 0 for node NFKBIA_S36 and TP53\n", + "looking for paths in the network with length: 1 for node NFKBIA_S36 and TP53\n", + "looking for paths in the network with length: 2 for node NFKBIA_S36 and TP53\n", + "looking for paths in the network with length: 3 for node NFKBIA_S36 and TP53\n", + "looking for paths in the network with length: 4 for node NFKBIA_S36 and TP53\n", + "looking for paths in the network with length: 5 for node NFKBIA_S36 and TP53\n", + "looking for paths in the network with length: 6 for node NFKBIA_S36 and TP53\n", + "looking for paths in the network with length: 7 for node NFKBIA_S36 and TP53\n", + "looking for paths in the network with length: 8 for node NFKBIA_S36 and TP53\n", + "looking for paths in the network with length: 9 for node NFKBIA_S36 and TP53\n", + "looking for paths in the network with length: 10 for node NFKBIA_S36 and TP53\n", + "i_search = 4\n", + "Looking for paths with length: 0 for node NFKBIA_S36 and TP53\n", + "i_search = 4\n", + "Looking for paths with length: 1 for node NFKBIA_S36 and TP53\n", + "i_search = 4\n", + "Looking for paths with length: 2 for node NFKBIA_S36 and TP53\n", + "i_search = 4\n", + "Looking for paths with length: 3 for node NFKBIA_S36 and TP53\n", + "i_search = 4\n", + "Looking for paths with length: 4 for node NFKBIA_S36 and TP53\n", + "looking for paths in the network with length: 0 for node NFKBIA_S36 and AKT1S1\n", + "looking for paths in the network with length: 1 for node NFKBIA_S36 and AKT1S1\n", + "looking for paths in the network with length: 2 for node NFKBIA_S36 and AKT1S1\n", + "looking for paths in the network with length: 3 for node NFKBIA_S36 and AKT1S1\n", + "looking for paths in the network with length: 4 for node NFKBIA_S36 and AKT1S1\n", + "looking for paths in the network with length: 5 for node NFKBIA_S36 and AKT1S1\n", + "looking for paths in the network with length: 6 for node NFKBIA_S36 and AKT1S1\n", + "looking for paths in the network with length: 7 for node NFKBIA_S36 and AKT1S1\n", + "looking for paths in the network with length: 8 for node NFKBIA_S36 and AKT1S1\n", + "looking for paths in the network with length: 9 for node NFKBIA_S36 and AKT1S1\n", + "looking for paths in the network with length: 10 for node NFKBIA_S36 and AKT1S1\n", + "i_search = 4\n", + "Looking for paths with length: 0 for node NFKBIA_S36 and AKT1S1\n", + "i_search = 4\n", + "Looking for paths with length: 1 for node NFKBIA_S36 and AKT1S1\n", + "i_search = 4\n", + "Looking for paths with length: 2 for node NFKBIA_S36 and AKT1S1\n", + "i_search = 4\n", + "Looking for paths with length: 3 for node NFKBIA_S36 and AKT1S1\n", + "i_search = 4\n", + "Looking for paths with length: 4 for node NFKBIA_S36 and AKT1S1\n", + "looking for paths in the network with length: 0 for node NFKBIA_S36 and GSK3B\n", + "looking for paths in the network with length: 1 for node NFKBIA_S36 and GSK3B\n", + "looking for paths in the network with length: 2 for node NFKBIA_S36 and GSK3B\n", + "looking for paths in the network with length: 3 for node NFKBIA_S36 and GSK3B\n", + "looking for paths in the network with length: 4 for node NFKBIA_S36 and GSK3B\n", + "looking for paths in the network with length: 5 for node NFKBIA_S36 and GSK3B\n", + "looking for paths in the network with length: 6 for node NFKBIA_S36 and GSK3B\n", + "looking for paths in the network with length: 7 for node NFKBIA_S36 and GSK3B\n", + "looking for paths in the network with length: 8 for node NFKBIA_S36 and GSK3B\n", + "looking for paths in the network with length: 9 for node NFKBIA_S36 and GSK3B\n", + "looking for paths in the network with length: 10 for node NFKBIA_S36 and GSK3B\n", + "i_search = 4\n", + "Looking for paths with length: 0 for node NFKBIA_S36 and GSK3B\n", + "i_search = 4\n", + "Looking for paths with length: 1 for node NFKBIA_S36 and GSK3B\n", + "i_search = 4\n", + "Looking for paths with length: 2 for node NFKBIA_S36 and GSK3B\n", + "i_search = 4\n", + "Looking for paths with length: 3 for node NFKBIA_S36 and GSK3B\n", + "i_search = 4\n", + "Looking for paths with length: 4 for node NFKBIA_S36 and GSK3B\n", + "looking for paths in the network with length: 0 for node NFKBIA_S36 and AKT1\n", + "looking for paths in the network with length: 1 for node NFKBIA_S36 and AKT1\n", + "looking for paths in the network with length: 2 for node NFKBIA_S36 and AKT1\n", + "looking for paths in the network with length: 3 for node NFKBIA_S36 and AKT1\n", + "looking for paths in the network with length: 4 for node NFKBIA_S36 and AKT1\n", + "looking for paths in the network with length: 5 for node NFKBIA_S36 and AKT1\n", + "looking for paths in the network with length: 6 for node NFKBIA_S36 and AKT1\n", + "looking for paths in the network with length: 7 for node NFKBIA_S36 and AKT1\n", + "looking for paths in the network with length: 8 for node NFKBIA_S36 and AKT1\n", + "looking for paths in the network with length: 9 for node NFKBIA_S36 and AKT1\n", + "looking for paths in the network with length: 10 for node NFKBIA_S36 and AKT1\n", + "i_search = 4\n", + "Looking for paths with length: 0 for node NFKBIA_S36 and AKT1\n", + "i_search = 4\n", + "Looking for paths with length: 1 for node NFKBIA_S36 and AKT1\n", + "i_search = 4\n", + "Looking for paths with length: 2 for node NFKBIA_S36 and AKT1\n", + "i_search = 4\n", + "Looking for paths with length: 3 for node NFKBIA_S36 and AKT1\n", + "i_search = 4\n", + "Looking for paths with length: 4 for node NFKBIA_S36 and AKT1\n", + "looking for paths in the network with length: 0 for node NFKBIA_S36 and HSPB1\n", + "looking for paths in the network with length: 1 for node NFKBIA_S36 and HSPB1\n", + "looking for paths in the network with length: 2 for node NFKBIA_S36 and HSPB1\n", + "looking for paths in the network with length: 3 for node NFKBIA_S36 and HSPB1\n", + "looking for paths in the network with length: 4 for node NFKBIA_S36 and HSPB1\n", + "looking for paths in the network with length: 5 for node NFKBIA_S36 and HSPB1\n", + "looking for paths in the network with length: 6 for node NFKBIA_S36 and HSPB1\n", + "looking for paths in the network with length: 7 for node NFKBIA_S36 and HSPB1\n", + "looking for paths in the network with length: 8 for node NFKBIA_S36 and HSPB1\n", + "looking for paths in the network with length: 9 for node NFKBIA_S36 and HSPB1\n", + "looking for paths in the network with length: 10 for node NFKBIA_S36 and HSPB1\n", + "i_search = 4\n", + "Looking for paths with length: 0 for node NFKBIA_S36 and HSPB1\n", + "i_search = 4\n", + "Looking for paths with length: 1 for node NFKBIA_S36 and HSPB1\n", + "i_search = 4\n", + "Looking for paths with length: 2 for node NFKBIA_S36 and HSPB1\n", + "i_search = 4\n", + "Looking for paths with length: 3 for node NFKBIA_S36 and HSPB1\n", + "i_search = 4\n", + "Looking for paths with length: 4 for node NFKBIA_S36 and HSPB1\n", + "looking for paths in the network with length: 0 for node NFKBIA_S36 and MAPK14\n", + "looking for paths in the network with length: 1 for node NFKBIA_S36 and MAPK14\n", + "looking for paths in the network with length: 2 for node NFKBIA_S36 and MAPK14\n", + "looking for paths in the network with length: 3 for node NFKBIA_S36 and MAPK14\n", + "looking for paths in the network with length: 4 for node NFKBIA_S36 and MAPK14\n", + "looking for paths in the network with length: 5 for node NFKBIA_S36 and MAPK14\n", + "looking for paths in the network with length: 6 for node NFKBIA_S36 and MAPK14\n", + "looking for paths in the network with length: 7 for node NFKBIA_S36 and MAPK14\n", + "looking for paths in the network with length: 8 for node NFKBIA_S36 and MAPK14\n", + "looking for paths in the network with length: 9 for node NFKBIA_S36 and MAPK14\n", + "looking for paths in the network with length: 10 for node NFKBIA_S36 and MAPK14\n", + "i_search = 4\n", + "Looking for paths with length: 0 for node NFKBIA_S36 and MAPK14\n", + "i_search = 4\n", + "Looking for paths with length: 1 for node NFKBIA_S36 and MAPK14\n", + "i_search = 4\n", + "Looking for paths with length: 2 for node NFKBIA_S36 and MAPK14\n", + "i_search = 4\n", + "Looking for paths with length: 3 for node NFKBIA_S36 and MAPK14\n", + "i_search = 4\n", + "Looking for paths with length: 4 for node NFKBIA_S36 and MAPK14\n", + "looking for paths in the network with length: 0 for node NFKBIA_S36 and MAP2K1\n", + "looking for paths in the network with length: 1 for node NFKBIA_S36 and MAP2K1\n", + "looking for paths in the network with length: 2 for node NFKBIA_S36 and MAP2K1\n", + "looking for paths in the network with length: 3 for node NFKBIA_S36 and MAP2K1\n", + "looking for paths in the network with length: 4 for node NFKBIA_S36 and MAP2K1\n", + "looking for paths in the network with length: 5 for node NFKBIA_S36 and MAP2K1\n", + "looking for paths in the network with length: 6 for node NFKBIA_S36 and MAP2K1\n", + "looking for paths in the network with length: 7 for node NFKBIA_S36 and MAP2K1\n", + "looking for paths in the network with length: 8 for node NFKBIA_S36 and MAP2K1\n", + "looking for paths in the network with length: 9 for node NFKBIA_S36 and MAP2K1\n", + "looking for paths in the network with length: 10 for node NFKBIA_S36 and MAP2K1\n", + "i_search = 4\n", + "Looking for paths with length: 0 for node NFKBIA_S36 and MAP2K1\n", + "i_search = 4\n", + "Looking for paths with length: 1 for node NFKBIA_S36 and MAP2K1\n", + "i_search = 4\n", + "Looking for paths with length: 2 for node NFKBIA_S36 and MAP2K1\n", + "i_search = 4\n", + "Looking for paths with length: 3 for node NFKBIA_S36 and MAP2K1\n", + "i_search = 4\n", + "Looking for paths with length: 4 for node NFKBIA_S36 and MAP2K1\n", + "looking for paths in the network with length: 0 for node NFKBIA_S36 and RPS6KA1\n", + "looking for paths in the network with length: 1 for node NFKBIA_S36 and RPS6KA1\n", + "looking for paths in the network with length: 2 for node NFKBIA_S36 and RPS6KA1\n", + "looking for paths in the network with length: 3 for node NFKBIA_S36 and RPS6KA1\n", + "looking for paths in the network with length: 4 for node NFKBIA_S36 and RPS6KA1\n", + "looking for paths in the network with length: 5 for node NFKBIA_S36 and RPS6KA1\n", + "looking for paths in the network with length: 6 for node NFKBIA_S36 and RPS6KA1\n", + "looking for paths in the network with length: 7 for node NFKBIA_S36 and RPS6KA1\n", + "looking for paths in the network with length: 8 for node NFKBIA_S36 and RPS6KA1\n", + "looking for paths in the network with length: 9 for node NFKBIA_S36 and RPS6KA1\n", + "looking for paths in the network with length: 10 for node NFKBIA_S36 and RPS6KA1\n", + "i_search = 4\n", + "Looking for paths with length: 0 for node NFKBIA_S36 and RPS6KA1\n", + "i_search = 4\n", + "Looking for paths with length: 1 for node NFKBIA_S36 and RPS6KA1\n", + "i_search = 4\n", + "Looking for paths with length: 2 for node NFKBIA_S36 and RPS6KA1\n", + "i_search = 4\n", + "Looking for paths with length: 3 for node NFKBIA_S36 and RPS6KA1\n", + "i_search = 4\n", + "Looking for paths with length: 4 for node NFKBIA_S36 and RPS6KA1\n", + "looking for paths in the network with length: 0 for node NFKBIA_S36 and CREB1\n", + "looking for paths in the network with length: 1 for node NFKBIA_S36 and CREB1\n", + "looking for paths in the network with length: 2 for node NFKBIA_S36 and CREB1\n", + "looking for paths in the network with length: 3 for node NFKBIA_S36 and CREB1\n", + "looking for paths in the network with length: 4 for node NFKBIA_S36 and CREB1\n", + "looking for paths in the network with length: 5 for node NFKBIA_S36 and CREB1\n", + "looking for paths in the network with length: 6 for node NFKBIA_S36 and CREB1\n", + "looking for paths in the network with length: 7 for node NFKBIA_S36 and CREB1\n", + "looking for paths in the network with length: 8 for node NFKBIA_S36 and CREB1\n", + "looking for paths in the network with length: 9 for node NFKBIA_S36 and CREB1\n", + "looking for paths in the network with length: 10 for node NFKBIA_S36 and CREB1\n", + "i_search = 4\n", + "Looking for paths with length: 0 for node NFKBIA_S36 and CREB1\n", + "i_search = 4\n", + "Looking for paths with length: 1 for node NFKBIA_S36 and CREB1\n", + "i_search = 4\n", + "Looking for paths with length: 2 for node NFKBIA_S36 and CREB1\n", + "i_search = 4\n", + "Looking for paths with length: 3 for node NFKBIA_S36 and CREB1\n", + "i_search = 4\n", + "Looking for paths with length: 4 for node NFKBIA_S36 and CREB1\n", + "looking for paths in the network with length: 0 for node NFKBIA_S36 and NFKBIA\n", + "looking for paths in the network with length: 1 for node NFKBIA_S36 and NFKBIA\n", + "looking for paths in the network with length: 2 for node NFKBIA_S36 and NFKBIA\n", + "looking for paths in the network with length: 3 for node NFKBIA_S36 and NFKBIA\n", + "looking for paths in the network with length: 4 for node NFKBIA_S36 and NFKBIA\n", + "looking for paths in the network with length: 5 for node NFKBIA_S36 and NFKBIA\n", + "looking for paths in the network with length: 6 for node NFKBIA_S36 and NFKBIA\n", + "looking for paths in the network with length: 7 for node NFKBIA_S36 and NFKBIA\n", + "looking for paths in the network with length: 8 for node NFKBIA_S36 and NFKBIA\n", + "looking for paths in the network with length: 9 for node NFKBIA_S36 and NFKBIA\n", + "looking for paths in the network with length: 10 for node NFKBIA_S36 and NFKBIA\n", + "i_search = 4\n", + "Looking for paths with length: 0 for node NFKBIA_S36 and NFKBIA\n", + "i_search = 4\n", + "Looking for paths with length: 1 for node NFKBIA_S36 and NFKBIA\n", + "i_search = 4\n", + "Looking for paths with length: 2 for node NFKBIA_S36 and NFKBIA\n", + "i_search = 4\n", + "Looking for paths with length: 3 for node NFKBIA_S36 and NFKBIA\n", + "i_search = 4\n", + "Looking for paths with length: 4 for node NFKBIA_S36 and NFKBIA\n", + "looking for paths in the network with length: 0 for node NFKBIA_S36 and MTOR\n", + "looking for paths in the network with length: 1 for node NFKBIA_S36 and MTOR\n", + "looking for paths in the network with length: 2 for node NFKBIA_S36 and MTOR\n", + "looking for paths in the network with length: 3 for node NFKBIA_S36 and MTOR\n", + "looking for paths in the network with length: 4 for node NFKBIA_S36 and MTOR\n", + "looking for paths in the network with length: 5 for node NFKBIA_S36 and MTOR\n", + "looking for paths in the network with length: 6 for node NFKBIA_S36 and MTOR\n", + "looking for paths in the network with length: 7 for node NFKBIA_S36 and MTOR\n", + "looking for paths in the network with length: 8 for node NFKBIA_S36 and MTOR\n", + "looking for paths in the network with length: 9 for node NFKBIA_S36 and MTOR\n", + "looking for paths in the network with length: 10 for node NFKBIA_S36 and MTOR\n", + "i_search = 4\n", + "Looking for paths with length: 0 for node NFKBIA_S36 and MTOR\n", + "i_search = 4\n", + "Looking for paths with length: 1 for node NFKBIA_S36 and MTOR\n", + "i_search = 4\n", + "Looking for paths with length: 2 for node NFKBIA_S36 and MTOR\n", + "i_search = 4\n", + "Looking for paths with length: 3 for node NFKBIA_S36 and MTOR\n", + "i_search = 4\n", + "Looking for paths with length: 4 for node NFKBIA_S36 and MTOR\n", + "looking for paths in the network with length: 0 for node NFKBIA_S36 and JUN\n", + "looking for paths in the network with length: 1 for node NFKBIA_S36 and JUN\n", + "looking for paths in the network with length: 2 for node NFKBIA_S36 and JUN\n", + "looking for paths in the network with length: 3 for node NFKBIA_S36 and JUN\n", + "looking for paths in the network with length: 4 for node NFKBIA_S36 and JUN\n", + "looking for paths in the network with length: 5 for node NFKBIA_S36 and JUN\n", + "looking for paths in the network with length: 6 for node NFKBIA_S36 and JUN\n", + "looking for paths in the network with length: 7 for node NFKBIA_S36 and JUN\n", + "looking for paths in the network with length: 8 for node NFKBIA_S36 and JUN\n", + "looking for paths in the network with length: 9 for node NFKBIA_S36 and JUN\n", + "looking for paths in the network with length: 10 for node NFKBIA_S36 and JUN\n", + "i_search = 4\n", + "Looking for paths with length: 0 for node NFKBIA_S36 and JUN\n", + "i_search = 4\n", + "Looking for paths with length: 1 for node NFKBIA_S36 and JUN\n", + "i_search = 4\n", + "Looking for paths with length: 2 for node NFKBIA_S36 and JUN\n", + "i_search = 4\n", + "Looking for paths with length: 3 for node NFKBIA_S36 and JUN\n", + "i_search = 4\n", + "Looking for paths with length: 4 for node NFKBIA_S36 and JUN\n", + "looking for paths in the network with length: 0 for node NFKBIA_S36 and EGFR\n", + "looking for paths in the network with length: 1 for node NFKBIA_S36 and EGFR\n", + "looking for paths in the network with length: 2 for node NFKBIA_S36 and EGFR\n", + "looking for paths in the network with length: 3 for node NFKBIA_S36 and EGFR\n", + "looking for paths in the network with length: 4 for node NFKBIA_S36 and EGFR\n", + "looking for paths in the network with length: 5 for node NFKBIA_S36 and EGFR\n", + "looking for paths in the network with length: 6 for node NFKBIA_S36 and EGFR\n", + "looking for paths in the network with length: 7 for node NFKBIA_S36 and EGFR\n", + "looking for paths in the network with length: 8 for node NFKBIA_S36 and EGFR\n", + "looking for paths in the network with length: 9 for node NFKBIA_S36 and EGFR\n", + "looking for paths in the network with length: 10 for node NFKBIA_S36 and EGFR\n", + "i_search = 4\n", + "Looking for paths with length: 0 for node NFKBIA_S36 and EGFR\n", + "i_search = 4\n", + "Looking for paths with length: 1 for node NFKBIA_S36 and EGFR\n", + "i_search = 4\n", + "Looking for paths with length: 2 for node NFKBIA_S36 and EGFR\n", + "i_search = 4\n", + "Looking for paths with length: 3 for node NFKBIA_S36 and EGFR\n", + "i_search = 4\n", + "Looking for paths with length: 4 for node NFKBIA_S36 and EGFR\n", + "looking for paths in the network with length: 0 for node NFKBIA_S36 and MAPK3\n", + "looking for paths in the network with length: 1 for node NFKBIA_S36 and MAPK3\n", + "looking for paths in the network with length: 2 for node NFKBIA_S36 and MAPK3\n", + "looking for paths in the network with length: 3 for node NFKBIA_S36 and MAPK3\n", + "looking for paths in the network with length: 4 for node NFKBIA_S36 and MAPK3\n", + "looking for paths in the network with length: 5 for node NFKBIA_S36 and MAPK3\n", + "looking for paths in the network with length: 6 for node NFKBIA_S36 and MAPK3\n", + "looking for paths in the network with length: 7 for node NFKBIA_S36 and MAPK3\n", + "looking for paths in the network with length: 8 for node NFKBIA_S36 and MAPK3\n", + "looking for paths in the network with length: 9 for node NFKBIA_S36 and MAPK3\n", + "looking for paths in the network with length: 10 for node NFKBIA_S36 and MAPK3\n", + "i_search = 4\n", + "Looking for paths with length: 0 for node NFKBIA_S36 and MAPK3\n", + "i_search = 4\n", + "Looking for paths with length: 1 for node NFKBIA_S36 and MAPK3\n", + "i_search = 4\n", + "Looking for paths with length: 2 for node NFKBIA_S36 and MAPK3\n", + "i_search = 4\n", + "Looking for paths with length: 3 for node NFKBIA_S36 and MAPK3\n", + "i_search = 4\n", + "Looking for paths with length: 4 for node NFKBIA_S36 and MAPK3\n", + "looking for paths in the network with length: 0 for node NFKBIA_S36 and PTPN11\n", + "looking for paths in the network with length: 1 for node NFKBIA_S36 and PTPN11\n", + "looking for paths in the network with length: 2 for node NFKBIA_S36 and PTPN11\n", + "looking for paths in the network with length: 3 for node NFKBIA_S36 and PTPN11\n", + "looking for paths in the network with length: 4 for node NFKBIA_S36 and PTPN11\n", + "looking for paths in the network with length: 5 for node NFKBIA_S36 and PTPN11\n", + "looking for paths in the network with length: 6 for node NFKBIA_S36 and PTPN11\n", + "looking for paths in the network with length: 7 for node NFKBIA_S36 and PTPN11\n", + "looking for paths in the network with length: 8 for node NFKBIA_S36 and PTPN11\n", + "looking for paths in the network with length: 9 for node NFKBIA_S36 and PTPN11\n", + "looking for paths in the network with length: 10 for node NFKBIA_S36 and PTPN11\n", + "i_search = 4\n", + "Looking for paths with length: 0 for node NFKBIA_S36 and PTPN11\n", + "i_search = 4\n", + "Looking for paths with length: 1 for node NFKBIA_S36 and PTPN11\n", + "i_search = 4\n", + "Looking for paths with length: 2 for node NFKBIA_S36 and PTPN11\n", + "i_search = 4\n", + "Looking for paths with length: 3 for node NFKBIA_S36 and PTPN11\n", + "i_search = 4\n", + "Looking for paths with length: 4 for node NFKBIA_S36 and PTPN11\n", + "looking for paths in the network with length: 0 for node NFKBIA_S36 and STAT3\n", + "looking for paths in the network with length: 1 for node NFKBIA_S36 and STAT3\n", + "looking for paths in the network with length: 2 for node NFKBIA_S36 and STAT3\n", + "looking for paths in the network with length: 3 for node NFKBIA_S36 and STAT3\n", + "looking for paths in the network with length: 4 for node NFKBIA_S36 and STAT3\n", + "looking for paths in the network with length: 5 for node NFKBIA_S36 and STAT3\n", + "looking for paths in the network with length: 6 for node NFKBIA_S36 and STAT3\n", + "looking for paths in the network with length: 7 for node NFKBIA_S36 and STAT3\n", + "looking for paths in the network with length: 8 for node NFKBIA_S36 and STAT3\n", + "looking for paths in the network with length: 9 for node NFKBIA_S36 and STAT3\n", + "looking for paths in the network with length: 10 for node NFKBIA_S36 and STAT3\n", + "i_search = 4\n", + "Looking for paths with length: 0 for node NFKBIA_S36 and STAT3\n", + "i_search = 4\n", + "Looking for paths with length: 1 for node NFKBIA_S36 and STAT3\n", + "i_search = 4\n", + "Looking for paths with length: 2 for node NFKBIA_S36 and STAT3\n", + "i_search = 4\n", + "Looking for paths with length: 3 for node NFKBIA_S36 and STAT3\n", + "i_search = 4\n", + "Looking for paths with length: 4 for node NFKBIA_S36 and STAT3\n", + "looking for paths in the network with length: 0 for node NFKBIA_S36 and CHEK2\n", + "looking for paths in the network with length: 1 for node NFKBIA_S36 and CHEK2\n", + "looking for paths in the network with length: 2 for node NFKBIA_S36 and CHEK2\n", + "looking for paths in the network with length: 3 for node NFKBIA_S36 and CHEK2\n", + "looking for paths in the network with length: 4 for node NFKBIA_S36 and CHEK2\n", + "looking for paths in the network with length: 5 for node NFKBIA_S36 and CHEK2\n", + "looking for paths in the network with length: 6 for node NFKBIA_S36 and CHEK2\n", + "looking for paths in the network with length: 7 for node NFKBIA_S36 and CHEK2\n", + "looking for paths in the network with length: 8 for node NFKBIA_S36 and CHEK2\n", + "looking for paths in the network with length: 9 for node NFKBIA_S36 and CHEK2\n", + "looking for paths in the network with length: 10 for node NFKBIA_S36 and CHEK2\n", + "i_search = 4\n", + "Looking for paths with length: 0 for node NFKBIA_S36 and CHEK2\n", + "i_search = 4\n", + "Looking for paths with length: 1 for node NFKBIA_S36 and CHEK2\n", + "i_search = 4\n", + "Looking for paths with length: 2 for node NFKBIA_S36 and CHEK2\n", + "i_search = 4\n", + "Looking for paths with length: 3 for node NFKBIA_S36 and CHEK2\n", + "i_search = 4\n", + "Looking for paths with length: 4 for node NFKBIA_S36 and CHEK2\n", + "looking for paths in the network with length: 0 for node NFKBIA_S36 and RELA\n", + "looking for paths in the network with length: 1 for node NFKBIA_S36 and RELA\n", + "looking for paths in the network with length: 2 for node NFKBIA_S36 and RELA\n", + "looking for paths in the network with length: 3 for node NFKBIA_S36 and RELA\n", + "looking for paths in the network with length: 4 for node NFKBIA_S36 and RELA\n", + "looking for paths in the network with length: 5 for node NFKBIA_S36 and RELA\n", + "looking for paths in the network with length: 6 for node NFKBIA_S36 and RELA\n", + "looking for paths in the network with length: 7 for node NFKBIA_S36 and RELA\n", + "looking for paths in the network with length: 8 for node NFKBIA_S36 and RELA\n", + "looking for paths in the network with length: 9 for node NFKBIA_S36 and RELA\n", + "looking for paths in the network with length: 10 for node NFKBIA_S36 and RELA\n", + "i_search = 4\n", + "Looking for paths with length: 0 for node NFKBIA_S36 and RELA\n", + "i_search = 4\n", + "Looking for paths with length: 1 for node NFKBIA_S36 and RELA\n", + "i_search = 4\n", + "Looking for paths with length: 2 for node NFKBIA_S36 and RELA\n", + "i_search = 4\n", + "Looking for paths with length: 3 for node NFKBIA_S36 and RELA\n", + "i_search = 4\n", + "Looking for paths with length: 4 for node NFKBIA_S36 and RELA\n", + "looking for paths in the network with length: 0 for node NFKBIA_S36 and MARCKS\n", + "looking for paths in the network with length: 1 for node NFKBIA_S36 and MARCKS\n", + "looking for paths in the network with length: 2 for node NFKBIA_S36 and MARCKS\n", + "looking for paths in the network with length: 3 for node NFKBIA_S36 and MARCKS\n", + "looking for paths in the network with length: 4 for node NFKBIA_S36 and MARCKS\n", + "looking for paths in the network with length: 5 for node NFKBIA_S36 and MARCKS\n", + "looking for paths in the network with length: 6 for node NFKBIA_S36 and MARCKS\n", + "looking for paths in the network with length: 7 for node NFKBIA_S36 and MARCKS\n", + "looking for paths in the network with length: 8 for node NFKBIA_S36 and MARCKS\n", + "looking for paths in the network with length: 9 for node NFKBIA_S36 and MARCKS\n", + "looking for paths in the network with length: 10 for node NFKBIA_S36 and MARCKS\n", + "i_search = 4\n", + "Looking for paths with length: 0 for node NFKBIA_S36 and MARCKS\n", + "i_search = 4\n", + "Looking for paths with length: 1 for node NFKBIA_S36 and MARCKS\n", + "i_search = 4\n", + "Looking for paths with length: 2 for node NFKBIA_S36 and MARCKS\n", + "i_search = 4\n", + "Looking for paths with length: 3 for node NFKBIA_S36 and MARCKS\n", + "i_search = 4\n", + "Looking for paths with length: 4 for node NFKBIA_S36 and MARCKS\n", + "looking for paths in the network with length: 0 for node MTOR_S2448 and JUN_S63\n", + "looking for paths in the network with length: 1 for node MTOR_S2448 and JUN_S63\n", + "looking for paths in the network with length: 2 for node MTOR_S2448 and JUN_S63\n", + "looking for paths in the network with length: 3 for node MTOR_S2448 and JUN_S63\n", + "looking for paths in the network with length: 4 for node MTOR_S2448 and JUN_S63\n", + "looking for paths in the network with length: 5 for node MTOR_S2448 and JUN_S63\n", + "looking for paths in the network with length: 6 for node MTOR_S2448 and JUN_S63\n", + "looking for paths in the network with length: 7 for node MTOR_S2448 and JUN_S63\n", + "looking for paths in the network with length: 8 for node MTOR_S2448 and JUN_S63\n", + "looking for paths in the network with length: 9 for node MTOR_S2448 and JUN_S63\n", + "looking for paths in the network with length: 10 for node MTOR_S2448 and JUN_S63\n", + "i_search = 4\n", + "Looking for paths with length: 0 for node MTOR_S2448 and JUN_S63\n", + "i_search = 4\n", + "Looking for paths with length: 1 for node MTOR_S2448 and JUN_S63\n", + "i_search = 4\n", + "Looking for paths with length: 2 for node MTOR_S2448 and JUN_S63\n", + "i_search = 4\n", + "Looking for paths with length: 3 for node MTOR_S2448 and JUN_S63\n", + "i_search = 4\n", + "Looking for paths with length: 4 for node MTOR_S2448 and JUN_S63\n", + "looking for paths in the network with length: 0 for node MTOR_S2448 and EGFR_Y1068\n", + "looking for paths in the network with length: 1 for node MTOR_S2448 and EGFR_Y1068\n", + "looking for paths in the network with length: 2 for node MTOR_S2448 and EGFR_Y1068\n", + "looking for paths in the network with length: 3 for node MTOR_S2448 and EGFR_Y1068\n", + "looking for paths in the network with length: 4 for node MTOR_S2448 and EGFR_Y1068\n", + "looking for paths in the network with length: 5 for node MTOR_S2448 and EGFR_Y1068\n", + "looking for paths in the network with length: 6 for node MTOR_S2448 and EGFR_Y1068\n", + "looking for paths in the network with length: 7 for node MTOR_S2448 and EGFR_Y1068\n", + "looking for paths in the network with length: 8 for node MTOR_S2448 and EGFR_Y1068\n", + "looking for paths in the network with length: 9 for node MTOR_S2448 and EGFR_Y1068\n", + "looking for paths in the network with length: 10 for node MTOR_S2448 and EGFR_Y1068\n", + "i_search = 4\n", + "Looking for paths with length: 0 for node MTOR_S2448 and EGFR_Y1068\n", + "i_search = 4\n", + "Looking for paths with length: 1 for node MTOR_S2448 and EGFR_Y1068\n", + "i_search = 4\n", + "Looking for paths with length: 2 for node MTOR_S2448 and EGFR_Y1068\n", + "i_search = 4\n", + "Looking for paths with length: 3 for node MTOR_S2448 and EGFR_Y1068\n", + "i_search = 4\n", + "Looking for paths with length: 4 for node MTOR_S2448 and EGFR_Y1068\n", + "looking for paths in the network with length: 0 for node MTOR_S2448 and MAPK3_T202\n", + "looking for paths in the network with length: 1 for node MTOR_S2448 and MAPK3_T202\n", + "looking for paths in the network with length: 2 for node MTOR_S2448 and MAPK3_T202\n", + "looking for paths in the network with length: 3 for node MTOR_S2448 and MAPK3_T202\n", + "looking for paths in the network with length: 4 for node MTOR_S2448 and MAPK3_T202\n", + "looking for paths in the network with length: 5 for node MTOR_S2448 and MAPK3_T202\n", + "looking for paths in the network with length: 6 for node MTOR_S2448 and MAPK3_T202\n", + "looking for paths in the network with length: 7 for node MTOR_S2448 and MAPK3_T202\n", + "looking for paths in the network with length: 8 for node MTOR_S2448 and MAPK3_T202\n", + "looking for paths in the network with length: 9 for node MTOR_S2448 and MAPK3_T202\n", + "looking for paths in the network with length: 10 for node MTOR_S2448 and MAPK3_T202\n", + "i_search = 4\n", + "Looking for paths with length: 0 for node MTOR_S2448 and MAPK3_T202\n", + "i_search = 4\n", + "Looking for paths with length: 1 for node MTOR_S2448 and MAPK3_T202\n", + "i_search = 4\n", + "Looking for paths with length: 2 for node MTOR_S2448 and MAPK3_T202\n", + "i_search = 4\n", + "Looking for paths with length: 3 for node MTOR_S2448 and MAPK3_T202\n", + "i_search = 4\n", + "Looking for paths with length: 4 for node MTOR_S2448 and MAPK3_T202\n", + "looking for paths in the network with length: 0 for node MTOR_S2448 and MAPK3_Y204\n", + "looking for paths in the network with length: 1 for node MTOR_S2448 and MAPK3_Y204\n", + "looking for paths in the network with length: 2 for node MTOR_S2448 and MAPK3_Y204\n", + "looking for paths in the network with length: 3 for node MTOR_S2448 and MAPK3_Y204\n", + "looking for paths in the network with length: 4 for node MTOR_S2448 and MAPK3_Y204\n", + "looking for paths in the network with length: 5 for node MTOR_S2448 and MAPK3_Y204\n", + "looking for paths in the network with length: 6 for node MTOR_S2448 and MAPK3_Y204\n", + "looking for paths in the network with length: 7 for node MTOR_S2448 and MAPK3_Y204\n", + "looking for paths in the network with length: 8 for node MTOR_S2448 and MAPK3_Y204\n", + "looking for paths in the network with length: 9 for node MTOR_S2448 and MAPK3_Y204\n", + "looking for paths in the network with length: 10 for node MTOR_S2448 and MAPK3_Y204\n", + "i_search = 4\n", + "Looking for paths with length: 0 for node MTOR_S2448 and MAPK3_Y204\n", + "i_search = 4\n", + "Looking for paths with length: 1 for node MTOR_S2448 and MAPK3_Y204\n", + "i_search = 4\n", + "Looking for paths with length: 2 for node MTOR_S2448 and MAPK3_Y204\n", + "i_search = 4\n", + "Looking for paths with length: 3 for node MTOR_S2448 and MAPK3_Y204\n", + "i_search = 4\n", + "Looking for paths with length: 4 for node MTOR_S2448 and MAPK3_Y204\n", + "looking for paths in the network with length: 0 for node MTOR_S2448 and PTPN11_Y542\n", + "looking for paths in the network with length: 1 for node MTOR_S2448 and PTPN11_Y542\n", + "looking for paths in the network with length: 2 for node MTOR_S2448 and PTPN11_Y542\n", + "looking for paths in the network with length: 3 for node MTOR_S2448 and PTPN11_Y542\n", + "looking for paths in the network with length: 4 for node MTOR_S2448 and PTPN11_Y542\n", + "looking for paths in the network with length: 5 for node MTOR_S2448 and PTPN11_Y542\n", + "looking for paths in the network with length: 6 for node MTOR_S2448 and PTPN11_Y542\n", + "looking for paths in the network with length: 7 for node MTOR_S2448 and PTPN11_Y542\n", + "looking for paths in the network with length: 8 for node MTOR_S2448 and PTPN11_Y542\n", + "looking for paths in the network with length: 9 for node MTOR_S2448 and PTPN11_Y542\n", + "looking for paths in the network with length: 10 for node MTOR_S2448 and PTPN11_Y542\n", + "i_search = 4\n", + "Looking for paths with length: 0 for node MTOR_S2448 and PTPN11_Y542\n", + "i_search = 4\n", + "Looking for paths with length: 1 for node MTOR_S2448 and PTPN11_Y542\n", + "i_search = 4\n", + "Looking for paths with length: 2 for node MTOR_S2448 and PTPN11_Y542\n", + "i_search = 4\n", + "Looking for paths with length: 3 for node MTOR_S2448 and PTPN11_Y542\n", + "i_search = 4\n", + "Looking for paths with length: 4 for node MTOR_S2448 and PTPN11_Y542\n", + "looking for paths in the network with length: 0 for node MTOR_S2448 and STAT3_Y705\n", + "looking for paths in the network with length: 1 for node MTOR_S2448 and STAT3_Y705\n", + "looking for paths in the network with length: 2 for node MTOR_S2448 and STAT3_Y705\n", + "looking for paths in the network with length: 3 for node MTOR_S2448 and STAT3_Y705\n", + "looking for paths in the network with length: 4 for node MTOR_S2448 and STAT3_Y705\n", + "looking for paths in the network with length: 5 for node MTOR_S2448 and STAT3_Y705\n", + "looking for paths in the network with length: 6 for node MTOR_S2448 and STAT3_Y705\n", + "looking for paths in the network with length: 7 for node MTOR_S2448 and STAT3_Y705\n", + "looking for paths in the network with length: 8 for node MTOR_S2448 and STAT3_Y705\n", + "looking for paths in the network with length: 9 for node MTOR_S2448 and STAT3_Y705\n", + "looking for paths in the network with length: 10 for node MTOR_S2448 and STAT3_Y705\n", + "i_search = 4\n", + "Looking for paths with length: 0 for node MTOR_S2448 and STAT3_Y705\n", + "i_search = 4\n", + "Looking for paths with length: 1 for node MTOR_S2448 and STAT3_Y705\n", + "i_search = 4\n", + "Looking for paths with length: 2 for node MTOR_S2448 and STAT3_Y705\n", + "i_search = 4\n", + "Looking for paths with length: 3 for node MTOR_S2448 and STAT3_Y705\n", + "i_search = 4\n", + "Looking for paths with length: 4 for node MTOR_S2448 and STAT3_Y705\n", + "[['MTOR_S2448', 'MTOR', 'EEF2K_S72', 'EEF2K', 'STAT3_Y705'], ['MTOR_S2448', 'MTOR', 'EEF2K_S74', 'EEF2K', 'STAT3_Y705']]\n", + "MTOR_S2448 MTOR\n", + "MTOR EEF2K_S72\n", + "EEF2K_S72 EEF2K\n", + "EEF2K STAT3_Y705\n", + "MTOR_S2448 MTOR\n", + "MTOR EEF2K_S74\n", + "EEF2K_S74 EEF2K\n", + "EEF2K STAT3_Y705\n", + "looking for paths in the network with length: 0 for node MTOR_S2448 and CHEK2_T68\n", + "looking for paths in the network with length: 1 for node MTOR_S2448 and CHEK2_T68\n", + "looking for paths in the network with length: 2 for node MTOR_S2448 and CHEK2_T68\n", + "looking for paths in the network with length: 3 for node MTOR_S2448 and CHEK2_T68\n", + "looking for paths in the network with length: 4 for node MTOR_S2448 and CHEK2_T68\n", + "looking for paths in the network with length: 5 for node MTOR_S2448 and CHEK2_T68\n", + "looking for paths in the network with length: 6 for node MTOR_S2448 and CHEK2_T68\n", + "looking for paths in the network with length: 7 for node MTOR_S2448 and CHEK2_T68\n", + "looking for paths in the network with length: 8 for node MTOR_S2448 and CHEK2_T68\n", + "looking for paths in the network with length: 9 for node MTOR_S2448 and CHEK2_T68\n", + "looking for paths in the network with length: 10 for node MTOR_S2448 and CHEK2_T68\n", + "i_search = 4\n", + "Looking for paths with length: 0 for node MTOR_S2448 and CHEK2_T68\n", + "i_search = 4\n", + "Looking for paths with length: 1 for node MTOR_S2448 and CHEK2_T68\n", + "i_search = 4\n", + "Looking for paths with length: 2 for node MTOR_S2448 and CHEK2_T68\n", + "i_search = 4\n", + "Looking for paths with length: 3 for node MTOR_S2448 and CHEK2_T68\n", + "i_search = 4\n", + "Looking for paths with length: 4 for node MTOR_S2448 and CHEK2_T68\n", + "looking for paths in the network with length: 0 for node MTOR_S2448 and RELA_S536\n", + "looking for paths in the network with length: 1 for node MTOR_S2448 and RELA_S536\n", + "looking for paths in the network with length: 2 for node MTOR_S2448 and RELA_S536\n", + "looking for paths in the network with length: 3 for node MTOR_S2448 and RELA_S536\n", + "looking for paths in the network with length: 4 for node MTOR_S2448 and RELA_S536\n", + "looking for paths in the network with length: 5 for node MTOR_S2448 and RELA_S536\n", + "looking for paths in the network with length: 6 for node MTOR_S2448 and RELA_S536\n", + "looking for paths in the network with length: 7 for node MTOR_S2448 and RELA_S536\n", + "looking for paths in the network with length: 8 for node MTOR_S2448 and RELA_S536\n", + "Found a path!\n", + "[['MTOR_S2448', 'MTOR', 'RPS6KB1_S434', 'RPS6KB1', 'GSK3B_S9', 'GSK3B', 'TBK1_S172', 'TBK1', 'RELA_S536'], ['MTOR_S2448', 'MTOR', 'AKT1_S473', 'AKT1', 'GSK3B_S9', 'GSK3B', 'TBK1_S172', 'TBK1', 'RELA_S536'], ['MTOR_S2448', 'MTOR', 'AKT1_T450', 'AKT1', 'GSK3B_S9', 'GSK3B', 'TBK1_S172', 'TBK1', 'RELA_S536'], ['MTOR_S2448', 'MTOR', 'EEF2K_S74', 'EEF2K', 'GSK3B_S9', 'GSK3B', 'TBK1_S172', 'TBK1', 'RELA_S536'], ['MTOR_S2448', 'MTOR', 'RPS6KB1_T389', 'RPS6KB1', 'GSK3B_S9', 'GSK3B', 'TBK1_S172', 'TBK1', 'RELA_S536'], ['MTOR_S2448', 'MTOR', 'PRKCB_T642', 'PRKCB', 'GSK3B_S9', 'GSK3B', 'TBK1_S172', 'TBK1', 'RELA_S536'], ['MTOR_S2448', 'MTOR', 'RPS6KB1_S394', 'RPS6KB1', 'GSK3B_S9', 'GSK3B', 'TBK1_S172', 'TBK1', 'RELA_S536'], ['MTOR_S2448', 'MTOR', 'EEF2K_S72', 'EEF2K', 'GSK3B_S9', 'GSK3B', 'TBK1_S172', 'TBK1', 'RELA_S536']]\n", + "looking for paths in the network with length: 0 for node MTOR_S2448 and MARCKS_S170\n", + "looking for paths in the network with length: 1 for node MTOR_S2448 and MARCKS_S170\n", + "looking for paths in the network with length: 2 for node MTOR_S2448 and MARCKS_S170\n", + "looking for paths in the network with length: 3 for node MTOR_S2448 and MARCKS_S170\n", + "looking for paths in the network with length: 4 for node MTOR_S2448 and MARCKS_S170\n", + "looking for paths in the network with length: 5 for node MTOR_S2448 and MARCKS_S170\n", + "looking for paths in the network with length: 6 for node MTOR_S2448 and MARCKS_S170\n", + "looking for paths in the network with length: 7 for node MTOR_S2448 and MARCKS_S170\n", + "looking for paths in the network with length: 8 for node MTOR_S2448 and MARCKS_S170\n", + "looking for paths in the network with length: 9 for node MTOR_S2448 and MARCKS_S170\n", + "looking for paths in the network with length: 10 for node MTOR_S2448 and MARCKS_S170\n", + "i_search = 4\n", + "Looking for paths with length: 0 for node MTOR_S2448 and MARCKS_S170\n", + "i_search = 4\n", + "Looking for paths with length: 1 for node MTOR_S2448 and MARCKS_S170\n", + "i_search = 4\n", + "Looking for paths with length: 2 for node MTOR_S2448 and MARCKS_S170\n", + "i_search = 4\n", + "Looking for paths with length: 3 for node MTOR_S2448 and MARCKS_S170\n", + "i_search = 4\n", + "Looking for paths with length: 4 for node MTOR_S2448 and MARCKS_S170\n", + "looking for paths in the network with length: 0 for node MTOR_S2448 and SMAD3\n", + "looking for paths in the network with length: 1 for node MTOR_S2448 and SMAD3\n", + "looking for paths in the network with length: 2 for node MTOR_S2448 and SMAD3\n", + "looking for paths in the network with length: 3 for node MTOR_S2448 and SMAD3\n", + "looking for paths in the network with length: 4 for node MTOR_S2448 and SMAD3\n", + "looking for paths in the network with length: 5 for node MTOR_S2448 and SMAD3\n", + "looking for paths in the network with length: 6 for node MTOR_S2448 and SMAD3\n", + "looking for paths in the network with length: 7 for node MTOR_S2448 and SMAD3\n", + "looking for paths in the network with length: 8 for node MTOR_S2448 and SMAD3\n", + "looking for paths in the network with length: 9 for node MTOR_S2448 and SMAD3\n", + "looking for paths in the network with length: 10 for node MTOR_S2448 and SMAD3\n", + "i_search = 4\n", + "Looking for paths with length: 0 for node MTOR_S2448 and SMAD3\n", + "i_search = 4\n", + "Looking for paths with length: 1 for node MTOR_S2448 and SMAD3\n", + "i_search = 4\n", + "Looking for paths with length: 2 for node MTOR_S2448 and SMAD3\n", + "i_search = 4\n", + "Looking for paths with length: 3 for node MTOR_S2448 and SMAD3\n", + "i_search = 4\n", + "Looking for paths with length: 4 for node MTOR_S2448 and SMAD3\n", + "looking for paths in the network with length: 0 for node MTOR_S2448 and TP53\n", + "looking for paths in the network with length: 1 for node MTOR_S2448 and TP53\n", + "looking for paths in the network with length: 2 for node MTOR_S2448 and TP53\n", + "looking for paths in the network with length: 3 for node MTOR_S2448 and TP53\n", + "looking for paths in the network with length: 4 for node MTOR_S2448 and TP53\n", + "looking for paths in the network with length: 5 for node MTOR_S2448 and TP53\n", + "looking for paths in the network with length: 6 for node MTOR_S2448 and TP53\n", + "looking for paths in the network with length: 7 for node MTOR_S2448 and TP53\n", + "looking for paths in the network with length: 8 for node MTOR_S2448 and TP53\n", + "looking for paths in the network with length: 9 for node MTOR_S2448 and TP53\n", + "looking for paths in the network with length: 10 for node MTOR_S2448 and TP53\n", + "i_search = 4\n", + "Looking for paths with length: 0 for node MTOR_S2448 and TP53\n", + "i_search = 4\n", + "Looking for paths with length: 1 for node MTOR_S2448 and TP53\n", + "i_search = 4\n", + "Looking for paths with length: 2 for node MTOR_S2448 and TP53\n", + "i_search = 4\n", + "Looking for paths with length: 3 for node MTOR_S2448 and TP53\n", + "i_search = 4\n", + "Looking for paths with length: 4 for node MTOR_S2448 and TP53\n", + "looking for paths in the network with length: 0 for node MTOR_S2448 and AKT1S1\n", + "looking for paths in the network with length: 1 for node MTOR_S2448 and AKT1S1\n", + "looking for paths in the network with length: 2 for node MTOR_S2448 and AKT1S1\n", + "looking for paths in the network with length: 3 for node MTOR_S2448 and AKT1S1\n", + "looking for paths in the network with length: 4 for node MTOR_S2448 and AKT1S1\n", + "looking for paths in the network with length: 5 for node MTOR_S2448 and AKT1S1\n", + "looking for paths in the network with length: 6 for node MTOR_S2448 and AKT1S1\n", + "looking for paths in the network with length: 7 for node MTOR_S2448 and AKT1S1\n", + "looking for paths in the network with length: 8 for node MTOR_S2448 and AKT1S1\n", + "looking for paths in the network with length: 9 for node MTOR_S2448 and AKT1S1\n", + "looking for paths in the network with length: 10 for node MTOR_S2448 and AKT1S1\n", + "i_search = 4\n", + "Looking for paths with length: 0 for node MTOR_S2448 and AKT1S1\n", + "i_search = 4\n", + "Looking for paths with length: 1 for node MTOR_S2448 and AKT1S1\n", + "i_search = 4\n", + "Looking for paths with length: 2 for node MTOR_S2448 and AKT1S1\n", + "i_search = 4\n", + "Looking for paths with length: 3 for node MTOR_S2448 and AKT1S1\n", + "i_search = 4\n", + "Looking for paths with length: 4 for node MTOR_S2448 and AKT1S1\n", + "looking for paths in the network with length: 0 for node MTOR_S2448 and GSK3B\n", + "looking for paths in the network with length: 1 for node MTOR_S2448 and GSK3B\n", + "looking for paths in the network with length: 2 for node MTOR_S2448 and GSK3B\n", + "looking for paths in the network with length: 3 for node MTOR_S2448 and GSK3B\n", + "looking for paths in the network with length: 4 for node MTOR_S2448 and GSK3B\n", + "looking for paths in the network with length: 5 for node MTOR_S2448 and GSK3B\n", + "looking for paths in the network with length: 6 for node MTOR_S2448 and GSK3B\n", + "looking for paths in the network with length: 7 for node MTOR_S2448 and GSK3B\n", + "looking for paths in the network with length: 8 for node MTOR_S2448 and GSK3B\n", + "looking for paths in the network with length: 9 for node MTOR_S2448 and GSK3B\n", + "looking for paths in the network with length: 10 for node MTOR_S2448 and GSK3B\n", + "i_search = 4\n", + "Looking for paths with length: 0 for node MTOR_S2448 and GSK3B\n", + "i_search = 4\n", + "Looking for paths with length: 1 for node MTOR_S2448 and GSK3B\n", + "i_search = 4\n", + "Looking for paths with length: 2 for node MTOR_S2448 and GSK3B\n", + "i_search = 4\n", + "Looking for paths with length: 3 for node MTOR_S2448 and GSK3B\n", + "i_search = 4\n", + "Looking for paths with length: 4 for node MTOR_S2448 and GSK3B\n", + "looking for paths in the network with length: 0 for node MTOR_S2448 and AKT1\n", + "looking for paths in the network with length: 1 for node MTOR_S2448 and AKT1\n", + "looking for paths in the network with length: 2 for node MTOR_S2448 and AKT1\n", + "looking for paths in the network with length: 3 for node MTOR_S2448 and AKT1\n", + "looking for paths in the network with length: 4 for node MTOR_S2448 and AKT1\n", + "looking for paths in the network with length: 5 for node MTOR_S2448 and AKT1\n", + "looking for paths in the network with length: 6 for node MTOR_S2448 and AKT1\n", + "looking for paths in the network with length: 7 for node MTOR_S2448 and AKT1\n", + "looking for paths in the network with length: 8 for node MTOR_S2448 and AKT1\n", + "looking for paths in the network with length: 9 for node MTOR_S2448 and AKT1\n", + "looking for paths in the network with length: 10 for node MTOR_S2448 and AKT1\n", + "i_search = 4\n", + "Looking for paths with length: 0 for node MTOR_S2448 and AKT1\n", + "i_search = 4\n", + "Looking for paths with length: 1 for node MTOR_S2448 and AKT1\n", + "i_search = 4\n", + "Looking for paths with length: 2 for node MTOR_S2448 and AKT1\n", + "i_search = 4\n", + "Looking for paths with length: 3 for node MTOR_S2448 and AKT1\n", + "i_search = 4\n", + "Looking for paths with length: 4 for node MTOR_S2448 and AKT1\n", + "looking for paths in the network with length: 0 for node MTOR_S2448 and HSPB1\n", + "looking for paths in the network with length: 1 for node MTOR_S2448 and HSPB1\n", + "looking for paths in the network with length: 2 for node MTOR_S2448 and HSPB1\n", + "looking for paths in the network with length: 3 for node MTOR_S2448 and HSPB1\n", + "looking for paths in the network with length: 4 for node MTOR_S2448 and HSPB1\n", + "looking for paths in the network with length: 5 for node MTOR_S2448 and HSPB1\n", + "looking for paths in the network with length: 6 for node MTOR_S2448 and HSPB1\n", + "looking for paths in the network with length: 7 for node MTOR_S2448 and HSPB1\n", + "looking for paths in the network with length: 8 for node MTOR_S2448 and HSPB1\n", + "looking for paths in the network with length: 9 for node MTOR_S2448 and HSPB1\n", + "looking for paths in the network with length: 10 for node MTOR_S2448 and HSPB1\n", + "i_search = 4\n", + "Looking for paths with length: 0 for node MTOR_S2448 and HSPB1\n", + "i_search = 4\n", + "Looking for paths with length: 1 for node MTOR_S2448 and HSPB1\n", + "i_search = 4\n", + "Looking for paths with length: 2 for node MTOR_S2448 and HSPB1\n", + "i_search = 4\n", + "Looking for paths with length: 3 for node MTOR_S2448 and HSPB1\n", + "i_search = 4\n", + "Looking for paths with length: 4 for node MTOR_S2448 and HSPB1\n", + "looking for paths in the network with length: 0 for node MTOR_S2448 and MAPK14\n", + "looking for paths in the network with length: 1 for node MTOR_S2448 and MAPK14\n", + "looking for paths in the network with length: 2 for node MTOR_S2448 and MAPK14\n", + "looking for paths in the network with length: 3 for node MTOR_S2448 and MAPK14\n", + "looking for paths in the network with length: 4 for node MTOR_S2448 and MAPK14\n", + "looking for paths in the network with length: 5 for node MTOR_S2448 and MAPK14\n", + "looking for paths in the network with length: 6 for node MTOR_S2448 and MAPK14\n", + "looking for paths in the network with length: 7 for node MTOR_S2448 and MAPK14\n", + "looking for paths in the network with length: 8 for node MTOR_S2448 and MAPK14\n", + "looking for paths in the network with length: 9 for node MTOR_S2448 and MAPK14\n", + "looking for paths in the network with length: 10 for node MTOR_S2448 and MAPK14\n", + "i_search = 4\n", + "Looking for paths with length: 0 for node MTOR_S2448 and MAPK14\n", + "i_search = 4\n", + "Looking for paths with length: 1 for node MTOR_S2448 and MAPK14\n", + "i_search = 4\n", + "Looking for paths with length: 2 for node MTOR_S2448 and MAPK14\n", + "i_search = 4\n", + "Looking for paths with length: 3 for node MTOR_S2448 and MAPK14\n", + "i_search = 4\n", + "Looking for paths with length: 4 for node MTOR_S2448 and MAPK14\n", + "looking for paths in the network with length: 0 for node MTOR_S2448 and MAP2K1\n", + "looking for paths in the network with length: 1 for node MTOR_S2448 and MAP2K1\n", + "looking for paths in the network with length: 2 for node MTOR_S2448 and MAP2K1\n", + "looking for paths in the network with length: 3 for node MTOR_S2448 and MAP2K1\n", + "looking for paths in the network with length: 4 for node MTOR_S2448 and MAP2K1\n", + "looking for paths in the network with length: 5 for node MTOR_S2448 and MAP2K1\n", + "looking for paths in the network with length: 6 for node MTOR_S2448 and MAP2K1\n", + "looking for paths in the network with length: 7 for node MTOR_S2448 and MAP2K1\n", + "looking for paths in the network with length: 8 for node MTOR_S2448 and MAP2K1\n", + "looking for paths in the network with length: 9 for node MTOR_S2448 and MAP2K1\n", + "looking for paths in the network with length: 10 for node MTOR_S2448 and MAP2K1\n", + "i_search = 4\n", + "Looking for paths with length: 0 for node MTOR_S2448 and MAP2K1\n", + "i_search = 4\n", + "Looking for paths with length: 1 for node MTOR_S2448 and MAP2K1\n", + "i_search = 4\n", + "Looking for paths with length: 2 for node MTOR_S2448 and MAP2K1\n", + "i_search = 4\n", + "Looking for paths with length: 3 for node MTOR_S2448 and MAP2K1\n", + "i_search = 4\n", + "Looking for paths with length: 4 for node MTOR_S2448 and MAP2K1\n", + "looking for paths in the network with length: 0 for node MTOR_S2448 and RPS6KA1\n", + "looking for paths in the network with length: 1 for node MTOR_S2448 and RPS6KA1\n", + "looking for paths in the network with length: 2 for node MTOR_S2448 and RPS6KA1\n", + "looking for paths in the network with length: 3 for node MTOR_S2448 and RPS6KA1\n", + "looking for paths in the network with length: 4 for node MTOR_S2448 and RPS6KA1\n", + "looking for paths in the network with length: 5 for node MTOR_S2448 and RPS6KA1\n", + "looking for paths in the network with length: 6 for node MTOR_S2448 and RPS6KA1\n", + "looking for paths in the network with length: 7 for node MTOR_S2448 and RPS6KA1\n", + "looking for paths in the network with length: 8 for node MTOR_S2448 and RPS6KA1\n", + "looking for paths in the network with length: 9 for node MTOR_S2448 and RPS6KA1\n", + "looking for paths in the network with length: 10 for node MTOR_S2448 and RPS6KA1\n", + "i_search = 4\n", + "Looking for paths with length: 0 for node MTOR_S2448 and RPS6KA1\n", + "i_search = 4\n", + "Looking for paths with length: 1 for node MTOR_S2448 and RPS6KA1\n", + "i_search = 4\n", + "Looking for paths with length: 2 for node MTOR_S2448 and RPS6KA1\n", + "i_search = 4\n", + "Looking for paths with length: 3 for node MTOR_S2448 and RPS6KA1\n", + "i_search = 4\n", + "Looking for paths with length: 4 for node MTOR_S2448 and RPS6KA1\n", + "looking for paths in the network with length: 0 for node MTOR_S2448 and CREB1\n", + "looking for paths in the network with length: 1 for node MTOR_S2448 and CREB1\n", + "looking for paths in the network with length: 2 for node MTOR_S2448 and CREB1\n", + "looking for paths in the network with length: 3 for node MTOR_S2448 and CREB1\n", + "looking for paths in the network with length: 4 for node MTOR_S2448 and CREB1\n", + "looking for paths in the network with length: 5 for node MTOR_S2448 and CREB1\n", + "looking for paths in the network with length: 6 for node MTOR_S2448 and CREB1\n", + "looking for paths in the network with length: 7 for node MTOR_S2448 and CREB1\n", + "looking for paths in the network with length: 8 for node MTOR_S2448 and CREB1\n", + "looking for paths in the network with length: 9 for node MTOR_S2448 and CREB1\n", + "looking for paths in the network with length: 10 for node MTOR_S2448 and CREB1\n", + "i_search = 4\n", + "Looking for paths with length: 0 for node MTOR_S2448 and CREB1\n", + "i_search = 4\n", + "Looking for paths with length: 1 for node MTOR_S2448 and CREB1\n", + "i_search = 4\n", + "Looking for paths with length: 2 for node MTOR_S2448 and CREB1\n", + "i_search = 4\n", + "Looking for paths with length: 3 for node MTOR_S2448 and CREB1\n", + "i_search = 4\n", + "Looking for paths with length: 4 for node MTOR_S2448 and CREB1\n", + "looking for paths in the network with length: 0 for node MTOR_S2448 and NFKBIA\n", + "looking for paths in the network with length: 1 for node MTOR_S2448 and NFKBIA\n", + "looking for paths in the network with length: 2 for node MTOR_S2448 and NFKBIA\n", + "looking for paths in the network with length: 3 for node MTOR_S2448 and NFKBIA\n", + "looking for paths in the network with length: 4 for node MTOR_S2448 and NFKBIA\n", + "looking for paths in the network with length: 5 for node MTOR_S2448 and NFKBIA\n", + "looking for paths in the network with length: 6 for node MTOR_S2448 and NFKBIA\n", + "looking for paths in the network with length: 7 for node MTOR_S2448 and NFKBIA\n", + "looking for paths in the network with length: 8 for node MTOR_S2448 and NFKBIA\n", + "looking for paths in the network with length: 9 for node MTOR_S2448 and NFKBIA\n", + "looking for paths in the network with length: 10 for node MTOR_S2448 and NFKBIA\n", + "i_search = 4\n", + "Looking for paths with length: 0 for node MTOR_S2448 and NFKBIA\n", + "i_search = 4\n", + "Looking for paths with length: 1 for node MTOR_S2448 and NFKBIA\n", + "i_search = 4\n", + "Looking for paths with length: 2 for node MTOR_S2448 and NFKBIA\n", + "i_search = 4\n", + "Looking for paths with length: 3 for node MTOR_S2448 and NFKBIA\n", + "i_search = 4\n", + "Looking for paths with length: 4 for node MTOR_S2448 and NFKBIA\n", + "looking for paths in the network with length: 0 for node MTOR_S2448 and MTOR\n", + "looking for paths in the network with length: 1 for node MTOR_S2448 and MTOR\n", + "looking for paths in the network with length: 2 for node MTOR_S2448 and MTOR\n", + "looking for paths in the network with length: 3 for node MTOR_S2448 and MTOR\n", + "looking for paths in the network with length: 4 for node MTOR_S2448 and MTOR\n", + "looking for paths in the network with length: 5 for node MTOR_S2448 and MTOR\n", + "looking for paths in the network with length: 6 for node MTOR_S2448 and MTOR\n", + "looking for paths in the network with length: 7 for node MTOR_S2448 and MTOR\n", + "looking for paths in the network with length: 8 for node MTOR_S2448 and MTOR\n", + "looking for paths in the network with length: 9 for node MTOR_S2448 and MTOR\n", + "looking for paths in the network with length: 10 for node MTOR_S2448 and MTOR\n", + "i_search = 4\n", + "Looking for paths with length: 0 for node MTOR_S2448 and MTOR\n", + "i_search = 4\n", + "Looking for paths with length: 1 for node MTOR_S2448 and MTOR\n", + "i_search = 4\n", + "Looking for paths with length: 2 for node MTOR_S2448 and MTOR\n", + "i_search = 4\n", + "Looking for paths with length: 3 for node MTOR_S2448 and MTOR\n", + "i_search = 4\n", + "Looking for paths with length: 4 for node MTOR_S2448 and MTOR\n", + "looking for paths in the network with length: 0 for node MTOR_S2448 and JUN\n", + "looking for paths in the network with length: 1 for node MTOR_S2448 and JUN\n", + "looking for paths in the network with length: 2 for node MTOR_S2448 and JUN\n", + "looking for paths in the network with length: 3 for node MTOR_S2448 and JUN\n", + "looking for paths in the network with length: 4 for node MTOR_S2448 and JUN\n", + "looking for paths in the network with length: 5 for node MTOR_S2448 and JUN\n", + "looking for paths in the network with length: 6 for node MTOR_S2448 and JUN\n", + "looking for paths in the network with length: 7 for node MTOR_S2448 and JUN\n", + "looking for paths in the network with length: 8 for node MTOR_S2448 and JUN\n", + "looking for paths in the network with length: 9 for node MTOR_S2448 and JUN\n", + "looking for paths in the network with length: 10 for node MTOR_S2448 and JUN\n", + "i_search = 4\n", + "Looking for paths with length: 0 for node MTOR_S2448 and JUN\n", + "i_search = 4\n", + "Looking for paths with length: 1 for node MTOR_S2448 and JUN\n", + "i_search = 4\n", + "Looking for paths with length: 2 for node MTOR_S2448 and JUN\n", + "i_search = 4\n", + "Looking for paths with length: 3 for node MTOR_S2448 and JUN\n", + "i_search = 4\n", + "Looking for paths with length: 4 for node MTOR_S2448 and JUN\n", + "looking for paths in the network with length: 0 for node MTOR_S2448 and EGFR\n", + "looking for paths in the network with length: 1 for node MTOR_S2448 and EGFR\n", + "looking for paths in the network with length: 2 for node MTOR_S2448 and EGFR\n", + "looking for paths in the network with length: 3 for node MTOR_S2448 and EGFR\n", + "looking for paths in the network with length: 4 for node MTOR_S2448 and EGFR\n", + "looking for paths in the network with length: 5 for node MTOR_S2448 and EGFR\n", + "looking for paths in the network with length: 6 for node MTOR_S2448 and EGFR\n", + "looking for paths in the network with length: 7 for node MTOR_S2448 and EGFR\n", + "looking for paths in the network with length: 8 for node MTOR_S2448 and EGFR\n", + "looking for paths in the network with length: 9 for node MTOR_S2448 and EGFR\n", + "looking for paths in the network with length: 10 for node MTOR_S2448 and EGFR\n", + "i_search = 4\n", + "Looking for paths with length: 0 for node MTOR_S2448 and EGFR\n", + "i_search = 4\n", + "Looking for paths with length: 1 for node MTOR_S2448 and EGFR\n", + "i_search = 4\n", + "Looking for paths with length: 2 for node MTOR_S2448 and EGFR\n", + "i_search = 4\n", + "Looking for paths with length: 3 for node MTOR_S2448 and EGFR\n", + "i_search = 4\n", + "Looking for paths with length: 4 for node MTOR_S2448 and EGFR\n", + "looking for paths in the network with length: 0 for node MTOR_S2448 and MAPK3\n", + "looking for paths in the network with length: 1 for node MTOR_S2448 and MAPK3\n", + "looking for paths in the network with length: 2 for node MTOR_S2448 and MAPK3\n", + "looking for paths in the network with length: 3 for node MTOR_S2448 and MAPK3\n", + "looking for paths in the network with length: 4 for node MTOR_S2448 and MAPK3\n", + "looking for paths in the network with length: 5 for node MTOR_S2448 and MAPK3\n", + "looking for paths in the network with length: 6 for node MTOR_S2448 and MAPK3\n", + "looking for paths in the network with length: 7 for node MTOR_S2448 and MAPK3\n", + "looking for paths in the network with length: 8 for node MTOR_S2448 and MAPK3\n", + "looking for paths in the network with length: 9 for node MTOR_S2448 and MAPK3\n", + "looking for paths in the network with length: 10 for node MTOR_S2448 and MAPK3\n", + "i_search = 4\n", + "Looking for paths with length: 0 for node MTOR_S2448 and MAPK3\n", + "i_search = 4\n", + "Looking for paths with length: 1 for node MTOR_S2448 and MAPK3\n", + "i_search = 4\n", + "Looking for paths with length: 2 for node MTOR_S2448 and MAPK3\n", + "i_search = 4\n", + "Looking for paths with length: 3 for node MTOR_S2448 and MAPK3\n", + "i_search = 4\n", + "Looking for paths with length: 4 for node MTOR_S2448 and MAPK3\n", + "looking for paths in the network with length: 0 for node MTOR_S2448 and PTPN11\n", + "looking for paths in the network with length: 1 for node MTOR_S2448 and PTPN11\n", + "looking for paths in the network with length: 2 for node MTOR_S2448 and PTPN11\n", + "looking for paths in the network with length: 3 for node MTOR_S2448 and PTPN11\n", + "looking for paths in the network with length: 4 for node MTOR_S2448 and PTPN11\n", + "looking for paths in the network with length: 5 for node MTOR_S2448 and PTPN11\n", + "looking for paths in the network with length: 6 for node MTOR_S2448 and PTPN11\n", + "looking for paths in the network with length: 7 for node MTOR_S2448 and PTPN11\n", + "looking for paths in the network with length: 8 for node MTOR_S2448 and PTPN11\n", + "looking for paths in the network with length: 9 for node MTOR_S2448 and PTPN11\n", + "looking for paths in the network with length: 10 for node MTOR_S2448 and PTPN11\n", + "i_search = 4\n", + "Looking for paths with length: 0 for node MTOR_S2448 and PTPN11\n", + "i_search = 4\n", + "Looking for paths with length: 1 for node MTOR_S2448 and PTPN11\n", + "i_search = 4\n", + "Looking for paths with length: 2 for node MTOR_S2448 and PTPN11\n", + "i_search = 4\n", + "Looking for paths with length: 3 for node MTOR_S2448 and PTPN11\n", + "i_search = 4\n", + "Looking for paths with length: 4 for node MTOR_S2448 and PTPN11\n", + "looking for paths in the network with length: 0 for node MTOR_S2448 and STAT3\n", + "looking for paths in the network with length: 1 for node MTOR_S2448 and STAT3\n", + "looking for paths in the network with length: 2 for node MTOR_S2448 and STAT3\n", + "looking for paths in the network with length: 3 for node MTOR_S2448 and STAT3\n", + "looking for paths in the network with length: 4 for node MTOR_S2448 and STAT3\n", + "looking for paths in the network with length: 5 for node MTOR_S2448 and STAT3\n", + "looking for paths in the network with length: 6 for node MTOR_S2448 and STAT3\n", + "looking for paths in the network with length: 7 for node MTOR_S2448 and STAT3\n", + "looking for paths in the network with length: 8 for node MTOR_S2448 and STAT3\n", + "looking for paths in the network with length: 9 for node MTOR_S2448 and STAT3\n", + "looking for paths in the network with length: 10 for node MTOR_S2448 and STAT3\n", + "i_search = 4\n", + "Looking for paths with length: 0 for node MTOR_S2448 and STAT3\n", + "i_search = 4\n", + "Looking for paths with length: 1 for node MTOR_S2448 and STAT3\n", + "i_search = 4\n", + "Looking for paths with length: 2 for node MTOR_S2448 and STAT3\n", + "i_search = 4\n", + "Looking for paths with length: 3 for node MTOR_S2448 and STAT3\n", + "i_search = 4\n", + "Looking for paths with length: 4 for node MTOR_S2448 and STAT3\n", + "looking for paths in the network with length: 0 for node MTOR_S2448 and CHEK2\n", + "looking for paths in the network with length: 1 for node MTOR_S2448 and CHEK2\n", + "looking for paths in the network with length: 2 for node MTOR_S2448 and CHEK2\n", + "looking for paths in the network with length: 3 for node MTOR_S2448 and CHEK2\n", + "looking for paths in the network with length: 4 for node MTOR_S2448 and CHEK2\n", + "looking for paths in the network with length: 5 for node MTOR_S2448 and CHEK2\n", + "looking for paths in the network with length: 6 for node MTOR_S2448 and CHEK2\n", + "looking for paths in the network with length: 7 for node MTOR_S2448 and CHEK2\n", + "looking for paths in the network with length: 8 for node MTOR_S2448 and CHEK2\n", + "looking for paths in the network with length: 9 for node MTOR_S2448 and CHEK2\n", + "looking for paths in the network with length: 10 for node MTOR_S2448 and CHEK2\n", + "i_search = 4\n", + "Looking for paths with length: 0 for node MTOR_S2448 and CHEK2\n", + "i_search = 4\n", + "Looking for paths with length: 1 for node MTOR_S2448 and CHEK2\n", + "i_search = 4\n", + "Looking for paths with length: 2 for node MTOR_S2448 and CHEK2\n", + "i_search = 4\n", + "Looking for paths with length: 3 for node MTOR_S2448 and CHEK2\n", + "i_search = 4\n", + "Looking for paths with length: 4 for node MTOR_S2448 and CHEK2\n", + "looking for paths in the network with length: 0 for node MTOR_S2448 and RELA\n", + "looking for paths in the network with length: 1 for node MTOR_S2448 and RELA\n", + "looking for paths in the network with length: 2 for node MTOR_S2448 and RELA\n", + "looking for paths in the network with length: 3 for node MTOR_S2448 and RELA\n", + "looking for paths in the network with length: 4 for node MTOR_S2448 and RELA\n", + "looking for paths in the network with length: 5 for node MTOR_S2448 and RELA\n", + "looking for paths in the network with length: 6 for node MTOR_S2448 and RELA\n", + "looking for paths in the network with length: 7 for node MTOR_S2448 and RELA\n", + "looking for paths in the network with length: 8 for node MTOR_S2448 and RELA\n", + "looking for paths in the network with length: 9 for node MTOR_S2448 and RELA\n", + "looking for paths in the network with length: 10 for node MTOR_S2448 and RELA\n", + "i_search = 4\n", + "Looking for paths with length: 0 for node MTOR_S2448 and RELA\n", + "i_search = 4\n", + "Looking for paths with length: 1 for node MTOR_S2448 and RELA\n", + "i_search = 4\n", + "Looking for paths with length: 2 for node MTOR_S2448 and RELA\n", + "i_search = 4\n", + "Looking for paths with length: 3 for node MTOR_S2448 and RELA\n", + "i_search = 4\n", + "Looking for paths with length: 4 for node MTOR_S2448 and RELA\n", + "looking for paths in the network with length: 0 for node MTOR_S2448 and MARCKS\n", + "looking for paths in the network with length: 1 for node MTOR_S2448 and MARCKS\n", + "looking for paths in the network with length: 2 for node MTOR_S2448 and MARCKS\n", + "looking for paths in the network with length: 3 for node MTOR_S2448 and MARCKS\n", + "looking for paths in the network with length: 4 for node MTOR_S2448 and MARCKS\n", + "looking for paths in the network with length: 5 for node MTOR_S2448 and MARCKS\n", + "looking for paths in the network with length: 6 for node MTOR_S2448 and MARCKS\n", + "looking for paths in the network with length: 7 for node MTOR_S2448 and MARCKS\n", + "looking for paths in the network with length: 8 for node MTOR_S2448 and MARCKS\n", + "looking for paths in the network with length: 9 for node MTOR_S2448 and MARCKS\n", + "looking for paths in the network with length: 10 for node MTOR_S2448 and MARCKS\n", + "i_search = 4\n", + "Looking for paths with length: 0 for node MTOR_S2448 and MARCKS\n", + "i_search = 4\n", + "Looking for paths with length: 1 for node MTOR_S2448 and MARCKS\n", + "i_search = 4\n", + "Looking for paths with length: 2 for node MTOR_S2448 and MARCKS\n", + "i_search = 4\n", + "Looking for paths with length: 3 for node MTOR_S2448 and MARCKS\n", + "i_search = 4\n", + "Looking for paths with length: 4 for node MTOR_S2448 and MARCKS\n", + "looking for paths in the network with length: 0 for node JUN_S63 and EGFR_Y1068\n", + "looking for paths in the network with length: 1 for node JUN_S63 and EGFR_Y1068\n", + "looking for paths in the network with length: 2 for node JUN_S63 and EGFR_Y1068\n", + "looking for paths in the network with length: 3 for node JUN_S63 and EGFR_Y1068\n", + "looking for paths in the network with length: 4 for node JUN_S63 and EGFR_Y1068\n", + "looking for paths in the network with length: 5 for node JUN_S63 and EGFR_Y1068\n", + "looking for paths in the network with length: 6 for node JUN_S63 and EGFR_Y1068\n", + "looking for paths in the network with length: 7 for node JUN_S63 and EGFR_Y1068\n", + "looking for paths in the network with length: 8 for node JUN_S63 and EGFR_Y1068\n", + "looking for paths in the network with length: 9 for node JUN_S63 and EGFR_Y1068\n", + "looking for paths in the network with length: 10 for node JUN_S63 and EGFR_Y1068\n", + "i_search = 4\n", + "Looking for paths with length: 0 for node JUN_S63 and EGFR_Y1068\n", + "i_search = 4\n", + "Looking for paths with length: 1 for node JUN_S63 and EGFR_Y1068\n", + "i_search = 4\n", + "Looking for paths with length: 2 for node JUN_S63 and EGFR_Y1068\n", + "i_search = 4\n", + "Looking for paths with length: 3 for node JUN_S63 and EGFR_Y1068\n", + "i_search = 4\n", + "Looking for paths with length: 4 for node JUN_S63 and EGFR_Y1068\n", + "looking for paths in the network with length: 0 for node JUN_S63 and MAPK3_T202\n", + "looking for paths in the network with length: 1 for node JUN_S63 and MAPK3_T202\n", + "looking for paths in the network with length: 2 for node JUN_S63 and MAPK3_T202\n", + "Found a path!\n", + "[['JUN_S63', 'MAPK3', 'MAPK3_T202']]\n", + "looking for paths in the network with length: 0 for node JUN_S63 and MAPK3_Y204\n", + "looking for paths in the network with length: 1 for node JUN_S63 and MAPK3_Y204\n", + "looking for paths in the network with length: 2 for node JUN_S63 and MAPK3_Y204\n", + "Found a path!\n", + "[['JUN_S63', 'MAPK3', 'MAPK3_Y204']]\n", + "looking for paths in the network with length: 0 for node JUN_S63 and PTPN11_Y542\n", + "looking for paths in the network with length: 1 for node JUN_S63 and PTPN11_Y542\n", + "looking for paths in the network with length: 2 for node JUN_S63 and PTPN11_Y542\n", + "looking for paths in the network with length: 3 for node JUN_S63 and PTPN11_Y542\n", + "looking for paths in the network with length: 4 for node JUN_S63 and PTPN11_Y542\n", + "looking for paths in the network with length: 5 for node JUN_S63 and PTPN11_Y542\n", + "looking for paths in the network with length: 6 for node JUN_S63 and PTPN11_Y542\n", + "looking for paths in the network with length: 7 for node JUN_S63 and PTPN11_Y542\n", + "looking for paths in the network with length: 8 for node JUN_S63 and PTPN11_Y542\n", + "looking for paths in the network with length: 9 for node JUN_S63 and PTPN11_Y542\n", + "looking for paths in the network with length: 10 for node JUN_S63 and PTPN11_Y542\n", + "i_search = 4\n", + "Looking for paths with length: 0 for node JUN_S63 and PTPN11_Y542\n", + "i_search = 4\n", + "Looking for paths with length: 1 for node JUN_S63 and PTPN11_Y542\n", + "i_search = 4\n", + "Looking for paths with length: 2 for node JUN_S63 and PTPN11_Y542\n", + "i_search = 4\n", + "Looking for paths with length: 3 for node JUN_S63 and PTPN11_Y542\n", + "i_search = 4\n", + "Looking for paths with length: 4 for node JUN_S63 and PTPN11_Y542\n", + "looking for paths in the network with length: 0 for node JUN_S63 and STAT3_Y705\n", + "looking for paths in the network with length: 1 for node JUN_S63 and STAT3_Y705\n", + "looking for paths in the network with length: 2 for node JUN_S63 and STAT3_Y705\n", + "looking for paths in the network with length: 3 for node JUN_S63 and STAT3_Y705\n", + "looking for paths in the network with length: 4 for node JUN_S63 and STAT3_Y705\n", + "looking for paths in the network with length: 5 for node JUN_S63 and STAT3_Y705\n", + "looking for paths in the network with length: 6 for node JUN_S63 and STAT3_Y705\n", + "looking for paths in the network with length: 7 for node JUN_S63 and STAT3_Y705\n", + "looking for paths in the network with length: 8 for node JUN_S63 and STAT3_Y705\n", + "looking for paths in the network with length: 9 for node JUN_S63 and STAT3_Y705\n", + "looking for paths in the network with length: 10 for node JUN_S63 and STAT3_Y705\n", + "i_search = 4\n", + "Looking for paths with length: 0 for node JUN_S63 and STAT3_Y705\n", + "i_search = 4\n", + "Looking for paths with length: 1 for node JUN_S63 and STAT3_Y705\n", + "i_search = 4\n", + "Looking for paths with length: 2 for node JUN_S63 and STAT3_Y705\n", + "i_search = 4\n", + "Looking for paths with length: 3 for node JUN_S63 and STAT3_Y705\n", + "i_search = 4\n", + "Looking for paths with length: 4 for node JUN_S63 and STAT3_Y705\n", + "looking for paths in the network with length: 0 for node JUN_S63 and CHEK2_T68\n", + "looking for paths in the network with length: 1 for node JUN_S63 and CHEK2_T68\n", + "looking for paths in the network with length: 2 for node JUN_S63 and CHEK2_T68\n", + "looking for paths in the network with length: 3 for node JUN_S63 and CHEK2_T68\n", + "looking for paths in the network with length: 4 for node JUN_S63 and CHEK2_T68\n", + "looking for paths in the network with length: 5 for node JUN_S63 and CHEK2_T68\n", + "looking for paths in the network with length: 6 for node JUN_S63 and CHEK2_T68\n", + "looking for paths in the network with length: 7 for node JUN_S63 and CHEK2_T68\n", + "looking for paths in the network with length: 8 for node JUN_S63 and CHEK2_T68\n", + "looking for paths in the network with length: 9 for node JUN_S63 and CHEK2_T68\n", + "looking for paths in the network with length: 10 for node JUN_S63 and CHEK2_T68\n", + "i_search = 4\n", + "Looking for paths with length: 0 for node JUN_S63 and CHEK2_T68\n", + "i_search = 4\n", + "Looking for paths with length: 1 for node JUN_S63 and CHEK2_T68\n", + "i_search = 4\n", + "Looking for paths with length: 2 for node JUN_S63 and CHEK2_T68\n", + "i_search = 4\n", + "Looking for paths with length: 3 for node JUN_S63 and CHEK2_T68\n", + "i_search = 4\n", + "Looking for paths with length: 4 for node JUN_S63 and CHEK2_T68\n", + "looking for paths in the network with length: 0 for node JUN_S63 and RELA_S536\n", + "looking for paths in the network with length: 1 for node JUN_S63 and RELA_S536\n", + "looking for paths in the network with length: 2 for node JUN_S63 and RELA_S536\n", + "looking for paths in the network with length: 3 for node JUN_S63 and RELA_S536\n", + "looking for paths in the network with length: 4 for node JUN_S63 and RELA_S536\n", + "looking for paths in the network with length: 5 for node JUN_S63 and RELA_S536\n", + "looking for paths in the network with length: 6 for node JUN_S63 and RELA_S536\n", + "looking for paths in the network with length: 7 for node JUN_S63 and RELA_S536\n", + "looking for paths in the network with length: 8 for node JUN_S63 and RELA_S536\n", + "looking for paths in the network with length: 9 for node JUN_S63 and RELA_S536\n", + "looking for paths in the network with length: 10 for node JUN_S63 and RELA_S536\n", + "i_search = 4\n", + "Looking for paths with length: 0 for node JUN_S63 and RELA_S536\n", + "i_search = 4\n", + "Looking for paths with length: 1 for node JUN_S63 and RELA_S536\n", + "i_search = 4\n", + "Looking for paths with length: 2 for node JUN_S63 and RELA_S536\n", + "i_search = 4\n", + "Looking for paths with length: 3 for node JUN_S63 and RELA_S536\n", + "i_search = 4\n", + "Looking for paths with length: 4 for node JUN_S63 and RELA_S536\n", + "looking for paths in the network with length: 0 for node JUN_S63 and MARCKS_S170\n", + "looking for paths in the network with length: 1 for node JUN_S63 and MARCKS_S170\n", + "looking for paths in the network with length: 2 for node JUN_S63 and MARCKS_S170\n", + "looking for paths in the network with length: 3 for node JUN_S63 and MARCKS_S170\n", + "looking for paths in the network with length: 4 for node JUN_S63 and MARCKS_S170\n", + "looking for paths in the network with length: 5 for node JUN_S63 and MARCKS_S170\n", + "looking for paths in the network with length: 6 for node JUN_S63 and MARCKS_S170\n", + "looking for paths in the network with length: 7 for node JUN_S63 and MARCKS_S170\n", + "looking for paths in the network with length: 8 for node JUN_S63 and MARCKS_S170\n", + "looking for paths in the network with length: 9 for node JUN_S63 and MARCKS_S170\n", + "looking for paths in the network with length: 10 for node JUN_S63 and MARCKS_S170\n", + "i_search = 4\n", + "Looking for paths with length: 0 for node JUN_S63 and MARCKS_S170\n", + "i_search = 4\n", + "Looking for paths with length: 1 for node JUN_S63 and MARCKS_S170\n", + "i_search = 4\n", + "Looking for paths with length: 2 for node JUN_S63 and MARCKS_S170\n", + "i_search = 4\n", + "Looking for paths with length: 3 for node JUN_S63 and MARCKS_S170\n", + "i_search = 4\n", + "Looking for paths with length: 4 for node JUN_S63 and MARCKS_S170\n", + "looking for paths in the network with length: 0 for node JUN_S63 and SMAD3\n", + "looking for paths in the network with length: 1 for node JUN_S63 and SMAD3\n", + "looking for paths in the network with length: 2 for node JUN_S63 and SMAD3\n", + "looking for paths in the network with length: 3 for node JUN_S63 and SMAD3\n", + "looking for paths in the network with length: 4 for node JUN_S63 and SMAD3\n", + "looking for paths in the network with length: 5 for node JUN_S63 and SMAD3\n", + "looking for paths in the network with length: 6 for node JUN_S63 and SMAD3\n", + "looking for paths in the network with length: 7 for node JUN_S63 and SMAD3\n", + "looking for paths in the network with length: 8 for node JUN_S63 and SMAD3\n", + "looking for paths in the network with length: 9 for node JUN_S63 and SMAD3\n", + "looking for paths in the network with length: 10 for node JUN_S63 and SMAD3\n", + "i_search = 4\n", + "Looking for paths with length: 0 for node JUN_S63 and SMAD3\n", + "i_search = 4\n", + "Looking for paths with length: 1 for node JUN_S63 and SMAD3\n", + "i_search = 4\n", + "Looking for paths with length: 2 for node JUN_S63 and SMAD3\n", + "i_search = 4\n", + "Looking for paths with length: 3 for node JUN_S63 and SMAD3\n", + "i_search = 4\n", + "Looking for paths with length: 4 for node JUN_S63 and SMAD3\n", + "looking for paths in the network with length: 0 for node JUN_S63 and TP53\n", + "looking for paths in the network with length: 1 for node JUN_S63 and TP53\n", + "looking for paths in the network with length: 2 for node JUN_S63 and TP53\n", + "looking for paths in the network with length: 3 for node JUN_S63 and TP53\n", + "looking for paths in the network with length: 4 for node JUN_S63 and TP53\n", + "looking for paths in the network with length: 5 for node JUN_S63 and TP53\n", + "looking for paths in the network with length: 6 for node JUN_S63 and TP53\n", + "looking for paths in the network with length: 7 for node JUN_S63 and TP53\n", + "looking for paths in the network with length: 8 for node JUN_S63 and TP53\n", + "looking for paths in the network with length: 9 for node JUN_S63 and TP53\n", + "looking for paths in the network with length: 10 for node JUN_S63 and TP53\n", + "i_search = 4\n", + "Looking for paths with length: 0 for node JUN_S63 and TP53\n", + "i_search = 4\n", + "Looking for paths with length: 1 for node JUN_S63 and TP53\n", + "i_search = 4\n", + "Looking for paths with length: 2 for node JUN_S63 and TP53\n", + "i_search = 4\n", + "Looking for paths with length: 3 for node JUN_S63 and TP53\n", + "i_search = 4\n", + "Looking for paths with length: 4 for node JUN_S63 and TP53\n", + "looking for paths in the network with length: 0 for node JUN_S63 and AKT1S1\n", + "looking for paths in the network with length: 1 for node JUN_S63 and AKT1S1\n", + "looking for paths in the network with length: 2 for node JUN_S63 and AKT1S1\n", + "looking for paths in the network with length: 3 for node JUN_S63 and AKT1S1\n", + "looking for paths in the network with length: 4 for node JUN_S63 and AKT1S1\n", + "looking for paths in the network with length: 5 for node JUN_S63 and AKT1S1\n", + "looking for paths in the network with length: 6 for node JUN_S63 and AKT1S1\n", + "looking for paths in the network with length: 7 for node JUN_S63 and AKT1S1\n", + "looking for paths in the network with length: 8 for node JUN_S63 and AKT1S1\n", + "looking for paths in the network with length: 9 for node JUN_S63 and AKT1S1\n", + "looking for paths in the network with length: 10 for node JUN_S63 and AKT1S1\n", + "i_search = 4\n", + "Looking for paths with length: 0 for node JUN_S63 and AKT1S1\n", + "i_search = 4\n", + "Looking for paths with length: 1 for node JUN_S63 and AKT1S1\n", + "i_search = 4\n", + "Looking for paths with length: 2 for node JUN_S63 and AKT1S1\n", + "i_search = 4\n", + "Looking for paths with length: 3 for node JUN_S63 and AKT1S1\n", + "i_search = 4\n", + "Looking for paths with length: 4 for node JUN_S63 and AKT1S1\n", + "looking for paths in the network with length: 0 for node JUN_S63 and GSK3B\n", + "looking for paths in the network with length: 1 for node JUN_S63 and GSK3B\n", + "looking for paths in the network with length: 2 for node JUN_S63 and GSK3B\n", + "looking for paths in the network with length: 3 for node JUN_S63 and GSK3B\n", + "looking for paths in the network with length: 4 for node JUN_S63 and GSK3B\n", + "looking for paths in the network with length: 5 for node JUN_S63 and GSK3B\n", + "looking for paths in the network with length: 6 for node JUN_S63 and GSK3B\n", + "looking for paths in the network with length: 7 for node JUN_S63 and GSK3B\n", + "looking for paths in the network with length: 8 for node JUN_S63 and GSK3B\n", + "looking for paths in the network with length: 9 for node JUN_S63 and GSK3B\n", + "looking for paths in the network with length: 10 for node JUN_S63 and GSK3B\n", + "i_search = 4\n", + "Looking for paths with length: 0 for node JUN_S63 and GSK3B\n", + "i_search = 4\n", + "Looking for paths with length: 1 for node JUN_S63 and GSK3B\n", + "i_search = 4\n", + "Looking for paths with length: 2 for node JUN_S63 and GSK3B\n", + "i_search = 4\n", + "Looking for paths with length: 3 for node JUN_S63 and GSK3B\n", + "i_search = 4\n", + "Looking for paths with length: 4 for node JUN_S63 and GSK3B\n", + "looking for paths in the network with length: 0 for node JUN_S63 and AKT1\n", + "looking for paths in the network with length: 1 for node JUN_S63 and AKT1\n", + "looking for paths in the network with length: 2 for node JUN_S63 and AKT1\n", + "looking for paths in the network with length: 3 for node JUN_S63 and AKT1\n", + "looking for paths in the network with length: 4 for node JUN_S63 and AKT1\n", + "looking for paths in the network with length: 5 for node JUN_S63 and AKT1\n", + "looking for paths in the network with length: 6 for node JUN_S63 and AKT1\n", + "looking for paths in the network with length: 7 for node JUN_S63 and AKT1\n", + "looking for paths in the network with length: 8 for node JUN_S63 and AKT1\n", + "looking for paths in the network with length: 9 for node JUN_S63 and AKT1\n", + "looking for paths in the network with length: 10 for node JUN_S63 and AKT1\n", + "i_search = 4\n", + "Looking for paths with length: 0 for node JUN_S63 and AKT1\n", + "i_search = 4\n", + "Looking for paths with length: 1 for node JUN_S63 and AKT1\n", + "i_search = 4\n", + "Looking for paths with length: 2 for node JUN_S63 and AKT1\n", + "i_search = 4\n", + "Looking for paths with length: 3 for node JUN_S63 and AKT1\n", + "i_search = 4\n", + "Looking for paths with length: 4 for node JUN_S63 and AKT1\n", + "looking for paths in the network with length: 0 for node JUN_S63 and HSPB1\n", + "looking for paths in the network with length: 1 for node JUN_S63 and HSPB1\n", + "looking for paths in the network with length: 2 for node JUN_S63 and HSPB1\n", + "looking for paths in the network with length: 3 for node JUN_S63 and HSPB1\n", + "looking for paths in the network with length: 4 for node JUN_S63 and HSPB1\n", + "looking for paths in the network with length: 5 for node JUN_S63 and HSPB1\n", + "looking for paths in the network with length: 6 for node JUN_S63 and HSPB1\n", + "looking for paths in the network with length: 7 for node JUN_S63 and HSPB1\n", + "looking for paths in the network with length: 8 for node JUN_S63 and HSPB1\n", + "looking for paths in the network with length: 9 for node JUN_S63 and HSPB1\n", + "looking for paths in the network with length: 10 for node JUN_S63 and HSPB1\n", + "i_search = 4\n", + "Looking for paths with length: 0 for node JUN_S63 and HSPB1\n", + "i_search = 4\n", + "Looking for paths with length: 1 for node JUN_S63 and HSPB1\n", + "i_search = 4\n", + "Looking for paths with length: 2 for node JUN_S63 and HSPB1\n", + "i_search = 4\n", + "Looking for paths with length: 3 for node JUN_S63 and HSPB1\n", + "i_search = 4\n", + "Looking for paths with length: 4 for node JUN_S63 and HSPB1\n", + "looking for paths in the network with length: 0 for node JUN_S63 and MAPK14\n", + "looking for paths in the network with length: 1 for node JUN_S63 and MAPK14\n", + "looking for paths in the network with length: 2 for node JUN_S63 and MAPK14\n", + "looking for paths in the network with length: 3 for node JUN_S63 and MAPK14\n", + "looking for paths in the network with length: 4 for node JUN_S63 and MAPK14\n", + "looking for paths in the network with length: 5 for node JUN_S63 and MAPK14\n", + "looking for paths in the network with length: 6 for node JUN_S63 and MAPK14\n", + "looking for paths in the network with length: 7 for node JUN_S63 and MAPK14\n", + "looking for paths in the network with length: 8 for node JUN_S63 and MAPK14\n", + "looking for paths in the network with length: 9 for node JUN_S63 and MAPK14\n", + "looking for paths in the network with length: 10 for node JUN_S63 and MAPK14\n", + "i_search = 4\n", + "Looking for paths with length: 0 for node JUN_S63 and MAPK14\n", + "i_search = 4\n", + "Looking for paths with length: 1 for node JUN_S63 and MAPK14\n", + "i_search = 4\n", + "Looking for paths with length: 2 for node JUN_S63 and MAPK14\n", + "i_search = 4\n", + "Looking for paths with length: 3 for node JUN_S63 and MAPK14\n", + "i_search = 4\n", + "Looking for paths with length: 4 for node JUN_S63 and MAPK14\n", + "looking for paths in the network with length: 0 for node JUN_S63 and MAP2K1\n", + "looking for paths in the network with length: 1 for node JUN_S63 and MAP2K1\n", + "looking for paths in the network with length: 2 for node JUN_S63 and MAP2K1\n", + "looking for paths in the network with length: 3 for node JUN_S63 and MAP2K1\n", + "looking for paths in the network with length: 4 for node JUN_S63 and MAP2K1\n", + "looking for paths in the network with length: 5 for node JUN_S63 and MAP2K1\n", + "looking for paths in the network with length: 6 for node JUN_S63 and MAP2K1\n", + "looking for paths in the network with length: 7 for node JUN_S63 and MAP2K1\n", + "looking for paths in the network with length: 8 for node JUN_S63 and MAP2K1\n", + "looking for paths in the network with length: 9 for node JUN_S63 and MAP2K1\n", + "looking for paths in the network with length: 10 for node JUN_S63 and MAP2K1\n", + "i_search = 4\n", + "Looking for paths with length: 0 for node JUN_S63 and MAP2K1\n", + "i_search = 4\n", + "Looking for paths with length: 1 for node JUN_S63 and MAP2K1\n", + "i_search = 4\n", + "Looking for paths with length: 2 for node JUN_S63 and MAP2K1\n", + "i_search = 4\n", + "Looking for paths with length: 3 for node JUN_S63 and MAP2K1\n", + "i_search = 4\n", + "Looking for paths with length: 4 for node JUN_S63 and MAP2K1\n", + "looking for paths in the network with length: 0 for node JUN_S63 and RPS6KA1\n", + "looking for paths in the network with length: 1 for node JUN_S63 and RPS6KA1\n", + "looking for paths in the network with length: 2 for node JUN_S63 and RPS6KA1\n", + "looking for paths in the network with length: 3 for node JUN_S63 and RPS6KA1\n", + "looking for paths in the network with length: 4 for node JUN_S63 and RPS6KA1\n", + "looking for paths in the network with length: 5 for node JUN_S63 and RPS6KA1\n", + "looking for paths in the network with length: 6 for node JUN_S63 and RPS6KA1\n", + "looking for paths in the network with length: 7 for node JUN_S63 and RPS6KA1\n", + "looking for paths in the network with length: 8 for node JUN_S63 and RPS6KA1\n", + "looking for paths in the network with length: 9 for node JUN_S63 and RPS6KA1\n", + "looking for paths in the network with length: 10 for node JUN_S63 and RPS6KA1\n", + "i_search = 4\n", + "Looking for paths with length: 0 for node JUN_S63 and RPS6KA1\n", + "i_search = 4\n", + "Looking for paths with length: 1 for node JUN_S63 and RPS6KA1\n", + "i_search = 4\n", + "Looking for paths with length: 2 for node JUN_S63 and RPS6KA1\n", + "i_search = 4\n", + "Looking for paths with length: 3 for node JUN_S63 and RPS6KA1\n", + "i_search = 4\n", + "Looking for paths with length: 4 for node JUN_S63 and RPS6KA1\n", + "looking for paths in the network with length: 0 for node JUN_S63 and CREB1\n", + "looking for paths in the network with length: 1 for node JUN_S63 and CREB1\n", + "looking for paths in the network with length: 2 for node JUN_S63 and CREB1\n", + "looking for paths in the network with length: 3 for node JUN_S63 and CREB1\n", + "looking for paths in the network with length: 4 for node JUN_S63 and CREB1\n", + "looking for paths in the network with length: 5 for node JUN_S63 and CREB1\n", + "looking for paths in the network with length: 6 for node JUN_S63 and CREB1\n", + "looking for paths in the network with length: 7 for node JUN_S63 and CREB1\n", + "looking for paths in the network with length: 8 for node JUN_S63 and CREB1\n", + "looking for paths in the network with length: 9 for node JUN_S63 and CREB1\n", + "looking for paths in the network with length: 10 for node JUN_S63 and CREB1\n", + "i_search = 4\n", + "Looking for paths with length: 0 for node JUN_S63 and CREB1\n", + "i_search = 4\n", + "Looking for paths with length: 1 for node JUN_S63 and CREB1\n", + "i_search = 4\n", + "Looking for paths with length: 2 for node JUN_S63 and CREB1\n", + "i_search = 4\n", + "Looking for paths with length: 3 for node JUN_S63 and CREB1\n", + "i_search = 4\n", + "Looking for paths with length: 4 for node JUN_S63 and CREB1\n", + "looking for paths in the network with length: 0 for node JUN_S63 and NFKBIA\n", + "looking for paths in the network with length: 1 for node JUN_S63 and NFKBIA\n", + "looking for paths in the network with length: 2 for node JUN_S63 and NFKBIA\n", + "looking for paths in the network with length: 3 for node JUN_S63 and NFKBIA\n", + "looking for paths in the network with length: 4 for node JUN_S63 and NFKBIA\n", + "looking for paths in the network with length: 5 for node JUN_S63 and NFKBIA\n", + "looking for paths in the network with length: 6 for node JUN_S63 and NFKBIA\n", + "looking for paths in the network with length: 7 for node JUN_S63 and NFKBIA\n", + "looking for paths in the network with length: 8 for node JUN_S63 and NFKBIA\n", + "looking for paths in the network with length: 9 for node JUN_S63 and NFKBIA\n", + "looking for paths in the network with length: 10 for node JUN_S63 and NFKBIA\n", + "i_search = 4\n", + "Looking for paths with length: 0 for node JUN_S63 and NFKBIA\n", + "i_search = 4\n", + "Looking for paths with length: 1 for node JUN_S63 and NFKBIA\n", + "i_search = 4\n", + "Looking for paths with length: 2 for node JUN_S63 and NFKBIA\n", + "i_search = 4\n", + "Looking for paths with length: 3 for node JUN_S63 and NFKBIA\n", + "i_search = 4\n", + "Looking for paths with length: 4 for node JUN_S63 and NFKBIA\n", + "looking for paths in the network with length: 0 for node JUN_S63 and MTOR\n", + "looking for paths in the network with length: 1 for node JUN_S63 and MTOR\n", + "looking for paths in the network with length: 2 for node JUN_S63 and MTOR\n", + "looking for paths in the network with length: 3 for node JUN_S63 and MTOR\n", + "looking for paths in the network with length: 4 for node JUN_S63 and MTOR\n", + "looking for paths in the network with length: 5 for node JUN_S63 and MTOR\n", + "looking for paths in the network with length: 6 for node JUN_S63 and MTOR\n", + "looking for paths in the network with length: 7 for node JUN_S63 and MTOR\n", + "looking for paths in the network with length: 8 for node JUN_S63 and MTOR\n", + "looking for paths in the network with length: 9 for node JUN_S63 and MTOR\n", + "looking for paths in the network with length: 10 for node JUN_S63 and MTOR\n", + "i_search = 4\n", + "Looking for paths with length: 0 for node JUN_S63 and MTOR\n", + "i_search = 4\n", + "Looking for paths with length: 1 for node JUN_S63 and MTOR\n", + "i_search = 4\n", + "Looking for paths with length: 2 for node JUN_S63 and MTOR\n", + "i_search = 4\n", + "Looking for paths with length: 3 for node JUN_S63 and MTOR\n", + "i_search = 4\n", + "Looking for paths with length: 4 for node JUN_S63 and MTOR\n", + "looking for paths in the network with length: 0 for node JUN_S63 and JUN\n", + "looking for paths in the network with length: 1 for node JUN_S63 and JUN\n", + "looking for paths in the network with length: 2 for node JUN_S63 and JUN\n", + "looking for paths in the network with length: 3 for node JUN_S63 and JUN\n", + "looking for paths in the network with length: 4 for node JUN_S63 and JUN\n", + "looking for paths in the network with length: 5 for node JUN_S63 and JUN\n", + "looking for paths in the network with length: 6 for node JUN_S63 and JUN\n", + "looking for paths in the network with length: 7 for node JUN_S63 and JUN\n", + "looking for paths in the network with length: 8 for node JUN_S63 and JUN\n", + "looking for paths in the network with length: 9 for node JUN_S63 and JUN\n", + "looking for paths in the network with length: 10 for node JUN_S63 and JUN\n", + "i_search = 4\n", + "Looking for paths with length: 0 for node JUN_S63 and JUN\n", + "i_search = 4\n", + "Looking for paths with length: 1 for node JUN_S63 and JUN\n", + "i_search = 4\n", + "Looking for paths with length: 2 for node JUN_S63 and JUN\n", + "i_search = 4\n", + "Looking for paths with length: 3 for node JUN_S63 and JUN\n", + "i_search = 4\n", + "Looking for paths with length: 4 for node JUN_S63 and JUN\n", + "looking for paths in the network with length: 0 for node JUN_S63 and EGFR\n", + "looking for paths in the network with length: 1 for node JUN_S63 and EGFR\n", + "looking for paths in the network with length: 2 for node JUN_S63 and EGFR\n", + "looking for paths in the network with length: 3 for node JUN_S63 and EGFR\n", + "looking for paths in the network with length: 4 for node JUN_S63 and EGFR\n", + "looking for paths in the network with length: 5 for node JUN_S63 and EGFR\n", + "looking for paths in the network with length: 6 for node JUN_S63 and EGFR\n", + "looking for paths in the network with length: 7 for node JUN_S63 and EGFR\n", + "looking for paths in the network with length: 8 for node JUN_S63 and EGFR\n", + "looking for paths in the network with length: 9 for node JUN_S63 and EGFR\n", + "looking for paths in the network with length: 10 for node JUN_S63 and EGFR\n", + "i_search = 4\n", + "Looking for paths with length: 0 for node JUN_S63 and EGFR\n", + "i_search = 4\n", + "Looking for paths with length: 1 for node JUN_S63 and EGFR\n", + "i_search = 4\n", + "Looking for paths with length: 2 for node JUN_S63 and EGFR\n", + "i_search = 4\n", + "Looking for paths with length: 3 for node JUN_S63 and EGFR\n", + "i_search = 4\n", + "Looking for paths with length: 4 for node JUN_S63 and EGFR\n", + "looking for paths in the network with length: 0 for node JUN_S63 and MAPK3\n", + "looking for paths in the network with length: 1 for node JUN_S63 and MAPK3\n", + "looking for paths in the network with length: 2 for node JUN_S63 and MAPK3\n", + "looking for paths in the network with length: 3 for node JUN_S63 and MAPK3\n", + "looking for paths in the network with length: 4 for node JUN_S63 and MAPK3\n", + "looking for paths in the network with length: 5 for node JUN_S63 and MAPK3\n", + "looking for paths in the network with length: 6 for node JUN_S63 and MAPK3\n", + "looking for paths in the network with length: 7 for node JUN_S63 and MAPK3\n", + "looking for paths in the network with length: 8 for node JUN_S63 and MAPK3\n", + "looking for paths in the network with length: 9 for node JUN_S63 and MAPK3\n", + "looking for paths in the network with length: 10 for node JUN_S63 and MAPK3\n", + "i_search = 4\n", + "Looking for paths with length: 0 for node JUN_S63 and MAPK3\n", + "i_search = 4\n", + "Looking for paths with length: 1 for node JUN_S63 and MAPK3\n", + "i_search = 4\n", + "Looking for paths with length: 2 for node JUN_S63 and MAPK3\n", + "i_search = 4\n", + "Looking for paths with length: 3 for node JUN_S63 and MAPK3\n", + "i_search = 4\n", + "Looking for paths with length: 4 for node JUN_S63 and MAPK3\n", + "looking for paths in the network with length: 0 for node JUN_S63 and PTPN11\n", + "looking for paths in the network with length: 1 for node JUN_S63 and PTPN11\n", + "looking for paths in the network with length: 2 for node JUN_S63 and PTPN11\n", + "looking for paths in the network with length: 3 for node JUN_S63 and PTPN11\n", + "looking for paths in the network with length: 4 for node JUN_S63 and PTPN11\n", + "looking for paths in the network with length: 5 for node JUN_S63 and PTPN11\n", + "looking for paths in the network with length: 6 for node JUN_S63 and PTPN11\n", + "looking for paths in the network with length: 7 for node JUN_S63 and PTPN11\n", + "looking for paths in the network with length: 8 for node JUN_S63 and PTPN11\n", + "looking for paths in the network with length: 9 for node JUN_S63 and PTPN11\n", + "looking for paths in the network with length: 10 for node JUN_S63 and PTPN11\n", + "i_search = 4\n", + "Looking for paths with length: 0 for node JUN_S63 and PTPN11\n", + "i_search = 4\n", + "Looking for paths with length: 1 for node JUN_S63 and PTPN11\n", + "i_search = 4\n", + "Looking for paths with length: 2 for node JUN_S63 and PTPN11\n", + "i_search = 4\n", + "Looking for paths with length: 3 for node JUN_S63 and PTPN11\n", + "i_search = 4\n", + "Looking for paths with length: 4 for node JUN_S63 and PTPN11\n", + "looking for paths in the network with length: 0 for node JUN_S63 and STAT3\n", + "looking for paths in the network with length: 1 for node JUN_S63 and STAT3\n", + "looking for paths in the network with length: 2 for node JUN_S63 and STAT3\n", + "looking for paths in the network with length: 3 for node JUN_S63 and STAT3\n", + "looking for paths in the network with length: 4 for node JUN_S63 and STAT3\n", + "looking for paths in the network with length: 5 for node JUN_S63 and STAT3\n", + "looking for paths in the network with length: 6 for node JUN_S63 and STAT3\n", + "looking for paths in the network with length: 7 for node JUN_S63 and STAT3\n", + "looking for paths in the network with length: 8 for node JUN_S63 and STAT3\n", + "looking for paths in the network with length: 9 for node JUN_S63 and STAT3\n", + "looking for paths in the network with length: 10 for node JUN_S63 and STAT3\n", + "i_search = 4\n", + "Looking for paths with length: 0 for node JUN_S63 and STAT3\n", + "i_search = 4\n", + "Looking for paths with length: 1 for node JUN_S63 and STAT3\n", + "i_search = 4\n", + "Looking for paths with length: 2 for node JUN_S63 and STAT3\n", + "i_search = 4\n", + "Looking for paths with length: 3 for node JUN_S63 and STAT3\n", + "i_search = 4\n", + "Looking for paths with length: 4 for node JUN_S63 and STAT3\n", + "looking for paths in the network with length: 0 for node JUN_S63 and CHEK2\n", + "looking for paths in the network with length: 1 for node JUN_S63 and CHEK2\n", + "looking for paths in the network with length: 2 for node JUN_S63 and CHEK2\n", + "looking for paths in the network with length: 3 for node JUN_S63 and CHEK2\n", + "looking for paths in the network with length: 4 for node JUN_S63 and CHEK2\n", + "looking for paths in the network with length: 5 for node JUN_S63 and CHEK2\n", + "looking for paths in the network with length: 6 for node JUN_S63 and CHEK2\n", + "looking for paths in the network with length: 7 for node JUN_S63 and CHEK2\n", + "looking for paths in the network with length: 8 for node JUN_S63 and CHEK2\n", + "looking for paths in the network with length: 9 for node JUN_S63 and CHEK2\n", + "looking for paths in the network with length: 10 for node JUN_S63 and CHEK2\n", + "i_search = 4\n", + "Looking for paths with length: 0 for node JUN_S63 and CHEK2\n", + "i_search = 4\n", + "Looking for paths with length: 1 for node JUN_S63 and CHEK2\n", + "i_search = 4\n", + "Looking for paths with length: 2 for node JUN_S63 and CHEK2\n", + "i_search = 4\n", + "Looking for paths with length: 3 for node JUN_S63 and CHEK2\n", + "i_search = 4\n", + "Looking for paths with length: 4 for node JUN_S63 and CHEK2\n", + "looking for paths in the network with length: 0 for node JUN_S63 and RELA\n", + "looking for paths in the network with length: 1 for node JUN_S63 and RELA\n", + "looking for paths in the network with length: 2 for node JUN_S63 and RELA\n", + "looking for paths in the network with length: 3 for node JUN_S63 and RELA\n", + "looking for paths in the network with length: 4 for node JUN_S63 and RELA\n", + "looking for paths in the network with length: 5 for node JUN_S63 and RELA\n", + "looking for paths in the network with length: 6 for node JUN_S63 and RELA\n", + "looking for paths in the network with length: 7 for node JUN_S63 and RELA\n", + "looking for paths in the network with length: 8 for node JUN_S63 and RELA\n", + "looking for paths in the network with length: 9 for node JUN_S63 and RELA\n", + "looking for paths in the network with length: 10 for node JUN_S63 and RELA\n", + "i_search = 4\n", + "Looking for paths with length: 0 for node JUN_S63 and RELA\n", + "i_search = 4\n", + "Looking for paths with length: 1 for node JUN_S63 and RELA\n", + "i_search = 4\n", + "Looking for paths with length: 2 for node JUN_S63 and RELA\n", + "i_search = 4\n", + "Looking for paths with length: 3 for node JUN_S63 and RELA\n", + "i_search = 4\n", + "Looking for paths with length: 4 for node JUN_S63 and RELA\n", + "looking for paths in the network with length: 0 for node JUN_S63 and MARCKS\n", + "looking for paths in the network with length: 1 for node JUN_S63 and MARCKS\n", + "looking for paths in the network with length: 2 for node JUN_S63 and MARCKS\n", + "looking for paths in the network with length: 3 for node JUN_S63 and MARCKS\n", + "looking for paths in the network with length: 4 for node JUN_S63 and MARCKS\n", + "looking for paths in the network with length: 5 for node JUN_S63 and MARCKS\n", + "looking for paths in the network with length: 6 for node JUN_S63 and MARCKS\n", + "looking for paths in the network with length: 7 for node JUN_S63 and MARCKS\n", + "looking for paths in the network with length: 8 for node JUN_S63 and MARCKS\n", + "looking for paths in the network with length: 9 for node JUN_S63 and MARCKS\n", + "looking for paths in the network with length: 10 for node JUN_S63 and MARCKS\n", + "i_search = 4\n", + "Looking for paths with length: 0 for node JUN_S63 and MARCKS\n", + "i_search = 4\n", + "Looking for paths with length: 1 for node JUN_S63 and MARCKS\n", + "i_search = 4\n", + "Looking for paths with length: 2 for node JUN_S63 and MARCKS\n", + "i_search = 4\n", + "Looking for paths with length: 3 for node JUN_S63 and MARCKS\n", + "i_search = 4\n", + "Looking for paths with length: 4 for node JUN_S63 and MARCKS\n", + "looking for paths in the network with length: 0 for node EGFR_Y1068 and MAPK3_T202\n", + "looking for paths in the network with length: 1 for node EGFR_Y1068 and MAPK3_T202\n", + "looking for paths in the network with length: 2 for node EGFR_Y1068 and MAPK3_T202\n", + "looking for paths in the network with length: 3 for node EGFR_Y1068 and MAPK3_T202\n", + "looking for paths in the network with length: 4 for node EGFR_Y1068 and MAPK3_T202\n", + "looking for paths in the network with length: 5 for node EGFR_Y1068 and MAPK3_T202\n", + "looking for paths in the network with length: 6 for node EGFR_Y1068 and MAPK3_T202\n", + "looking for paths in the network with length: 7 for node EGFR_Y1068 and MAPK3_T202\n", + "looking for paths in the network with length: 8 for node EGFR_Y1068 and MAPK3_T202\n", + "looking for paths in the network with length: 9 for node EGFR_Y1068 and MAPK3_T202\n", + "looking for paths in the network with length: 10 for node EGFR_Y1068 and MAPK3_T202\n", + "i_search = 4\n", + "Looking for paths with length: 0 for node EGFR_Y1068 and MAPK3_T202\n", + "i_search = 4\n", + "Looking for paths with length: 1 for node EGFR_Y1068 and MAPK3_T202\n", + "i_search = 4\n", + "Looking for paths with length: 2 for node EGFR_Y1068 and MAPK3_T202\n", + "i_search = 4\n", + "Looking for paths with length: 3 for node EGFR_Y1068 and MAPK3_T202\n", + "i_search = 4\n", + "Looking for paths with length: 4 for node EGFR_Y1068 and MAPK3_T202\n", + "looking for paths in the network with length: 0 for node EGFR_Y1068 and MAPK3_Y204\n", + "looking for paths in the network with length: 1 for node EGFR_Y1068 and MAPK3_Y204\n", + "looking for paths in the network with length: 2 for node EGFR_Y1068 and MAPK3_Y204\n", + "looking for paths in the network with length: 3 for node EGFR_Y1068 and MAPK3_Y204\n", + "looking for paths in the network with length: 4 for node EGFR_Y1068 and MAPK3_Y204\n", + "looking for paths in the network with length: 5 for node EGFR_Y1068 and MAPK3_Y204\n", + "looking for paths in the network with length: 6 for node EGFR_Y1068 and MAPK3_Y204\n", + "looking for paths in the network with length: 7 for node EGFR_Y1068 and MAPK3_Y204\n", + "looking for paths in the network with length: 8 for node EGFR_Y1068 and MAPK3_Y204\n", + "looking for paths in the network with length: 9 for node EGFR_Y1068 and MAPK3_Y204\n", + "looking for paths in the network with length: 10 for node EGFR_Y1068 and MAPK3_Y204\n", + "i_search = 4\n", + "Looking for paths with length: 0 for node EGFR_Y1068 and MAPK3_Y204\n", + "i_search = 4\n", + "Looking for paths with length: 1 for node EGFR_Y1068 and MAPK3_Y204\n", + "i_search = 4\n", + "Looking for paths with length: 2 for node EGFR_Y1068 and MAPK3_Y204\n", + "i_search = 4\n", + "Looking for paths with length: 3 for node EGFR_Y1068 and MAPK3_Y204\n", + "i_search = 4\n", + "Looking for paths with length: 4 for node EGFR_Y1068 and MAPK3_Y204\n", + "looking for paths in the network with length: 0 for node EGFR_Y1068 and PTPN11_Y542\n", + "looking for paths in the network with length: 1 for node EGFR_Y1068 and PTPN11_Y542\n", + "looking for paths in the network with length: 2 for node EGFR_Y1068 and PTPN11_Y542\n", + "looking for paths in the network with length: 3 for node EGFR_Y1068 and PTPN11_Y542\n", + "looking for paths in the network with length: 4 for node EGFR_Y1068 and PTPN11_Y542\n", + "looking for paths in the network with length: 5 for node EGFR_Y1068 and PTPN11_Y542\n", + "looking for paths in the network with length: 6 for node EGFR_Y1068 and PTPN11_Y542\n", + "looking for paths in the network with length: 7 for node EGFR_Y1068 and PTPN11_Y542\n", + "looking for paths in the network with length: 8 for node EGFR_Y1068 and PTPN11_Y542\n", + "looking for paths in the network with length: 9 for node EGFR_Y1068 and PTPN11_Y542\n", + "looking for paths in the network with length: 10 for node EGFR_Y1068 and PTPN11_Y542\n", + "i_search = 4\n", + "Looking for paths with length: 0 for node EGFR_Y1068 and PTPN11_Y542\n", + "i_search = 4\n", + "Looking for paths with length: 1 for node EGFR_Y1068 and PTPN11_Y542\n", + "i_search = 4\n", + "Looking for paths with length: 2 for node EGFR_Y1068 and PTPN11_Y542\n", + "i_search = 4\n", + "Looking for paths with length: 3 for node EGFR_Y1068 and PTPN11_Y542\n", + "i_search = 4\n", + "Looking for paths with length: 4 for node EGFR_Y1068 and PTPN11_Y542\n", + "looking for paths in the network with length: 0 for node EGFR_Y1068 and STAT3_Y705\n", + "looking for paths in the network with length: 1 for node EGFR_Y1068 and STAT3_Y705\n", + "looking for paths in the network with length: 2 for node EGFR_Y1068 and STAT3_Y705\n", + "looking for paths in the network with length: 3 for node EGFR_Y1068 and STAT3_Y705\n", + "looking for paths in the network with length: 4 for node EGFR_Y1068 and STAT3_Y705\n", + "looking for paths in the network with length: 5 for node EGFR_Y1068 and STAT3_Y705\n", + "looking for paths in the network with length: 6 for node EGFR_Y1068 and STAT3_Y705\n", + "looking for paths in the network with length: 7 for node EGFR_Y1068 and STAT3_Y705\n", + "looking for paths in the network with length: 8 for node EGFR_Y1068 and STAT3_Y705\n", + "looking for paths in the network with length: 9 for node EGFR_Y1068 and STAT3_Y705\n", + "looking for paths in the network with length: 10 for node EGFR_Y1068 and STAT3_Y705\n", + "i_search = 4\n", + "Looking for paths with length: 0 for node EGFR_Y1068 and STAT3_Y705\n", + "i_search = 4\n", + "Looking for paths with length: 1 for node EGFR_Y1068 and STAT3_Y705\n", + "i_search = 4\n", + "Looking for paths with length: 2 for node EGFR_Y1068 and STAT3_Y705\n", + "i_search = 4\n", + "Looking for paths with length: 3 for node EGFR_Y1068 and STAT3_Y705\n", + "i_search = 4\n", + "Looking for paths with length: 4 for node EGFR_Y1068 and STAT3_Y705\n", + "looking for paths in the network with length: 0 for node EGFR_Y1068 and CHEK2_T68\n", + "looking for paths in the network with length: 1 for node EGFR_Y1068 and CHEK2_T68\n", + "looking for paths in the network with length: 2 for node EGFR_Y1068 and CHEK2_T68\n", + "looking for paths in the network with length: 3 for node EGFR_Y1068 and CHEK2_T68\n", + "looking for paths in the network with length: 4 for node EGFR_Y1068 and CHEK2_T68\n", + "looking for paths in the network with length: 5 for node EGFR_Y1068 and CHEK2_T68\n", + "looking for paths in the network with length: 6 for node EGFR_Y1068 and CHEK2_T68\n", + "looking for paths in the network with length: 7 for node EGFR_Y1068 and CHEK2_T68\n", + "looking for paths in the network with length: 8 for node EGFR_Y1068 and CHEK2_T68\n", + "looking for paths in the network with length: 9 for node EGFR_Y1068 and CHEK2_T68\n", + "looking for paths in the network with length: 10 for node EGFR_Y1068 and CHEK2_T68\n", + "i_search = 4\n", + "Looking for paths with length: 0 for node EGFR_Y1068 and CHEK2_T68\n", + "i_search = 4\n", + "Looking for paths with length: 1 for node EGFR_Y1068 and CHEK2_T68\n", + "i_search = 4\n", + "Looking for paths with length: 2 for node EGFR_Y1068 and CHEK2_T68\n", + "i_search = 4\n", + "Looking for paths with length: 3 for node EGFR_Y1068 and CHEK2_T68\n", + "i_search = 4\n", + "Looking for paths with length: 4 for node EGFR_Y1068 and CHEK2_T68\n", + "looking for paths in the network with length: 0 for node EGFR_Y1068 and RELA_S536\n", + "looking for paths in the network with length: 1 for node EGFR_Y1068 and RELA_S536\n", + "looking for paths in the network with length: 2 for node EGFR_Y1068 and RELA_S536\n", + "looking for paths in the network with length: 3 for node EGFR_Y1068 and RELA_S536\n", + "looking for paths in the network with length: 4 for node EGFR_Y1068 and RELA_S536\n", + "looking for paths in the network with length: 5 for node EGFR_Y1068 and RELA_S536\n", + "looking for paths in the network with length: 6 for node EGFR_Y1068 and RELA_S536\n", + "looking for paths in the network with length: 7 for node EGFR_Y1068 and RELA_S536\n", + "looking for paths in the network with length: 8 for node EGFR_Y1068 and RELA_S536\n", + "looking for paths in the network with length: 9 for node EGFR_Y1068 and RELA_S536\n", + "looking for paths in the network with length: 10 for node EGFR_Y1068 and RELA_S536\n", + "i_search = 4\n", + "Looking for paths with length: 0 for node EGFR_Y1068 and RELA_S536\n", + "i_search = 4\n", + "Looking for paths with length: 1 for node EGFR_Y1068 and RELA_S536\n", + "i_search = 4\n", + "Looking for paths with length: 2 for node EGFR_Y1068 and RELA_S536\n", + "i_search = 4\n", + "Looking for paths with length: 3 for node EGFR_Y1068 and RELA_S536\n", + "i_search = 4\n", + "Looking for paths with length: 4 for node EGFR_Y1068 and RELA_S536\n", + "looking for paths in the network with length: 0 for node EGFR_Y1068 and MARCKS_S170\n", + "looking for paths in the network with length: 1 for node EGFR_Y1068 and MARCKS_S170\n", + "looking for paths in the network with length: 2 for node EGFR_Y1068 and MARCKS_S170\n", + "looking for paths in the network with length: 3 for node EGFR_Y1068 and MARCKS_S170\n", + "looking for paths in the network with length: 4 for node EGFR_Y1068 and MARCKS_S170\n", + "looking for paths in the network with length: 5 for node EGFR_Y1068 and MARCKS_S170\n", + "looking for paths in the network with length: 6 for node EGFR_Y1068 and MARCKS_S170\n", + "looking for paths in the network with length: 7 for node EGFR_Y1068 and MARCKS_S170\n", + "looking for paths in the network with length: 8 for node EGFR_Y1068 and MARCKS_S170\n", + "looking for paths in the network with length: 9 for node EGFR_Y1068 and MARCKS_S170\n", + "looking for paths in the network with length: 10 for node EGFR_Y1068 and MARCKS_S170\n", + "i_search = 4\n", + "Looking for paths with length: 0 for node EGFR_Y1068 and MARCKS_S170\n", + "i_search = 4\n", + "Looking for paths with length: 1 for node EGFR_Y1068 and MARCKS_S170\n", + "i_search = 4\n", + "Looking for paths with length: 2 for node EGFR_Y1068 and MARCKS_S170\n", + "i_search = 4\n", + "Looking for paths with length: 3 for node EGFR_Y1068 and MARCKS_S170\n", + "i_search = 4\n", + "Looking for paths with length: 4 for node EGFR_Y1068 and MARCKS_S170\n", + "looking for paths in the network with length: 0 for node EGFR_Y1068 and SMAD3\n", + "looking for paths in the network with length: 1 for node EGFR_Y1068 and SMAD3\n", + "looking for paths in the network with length: 2 for node EGFR_Y1068 and SMAD3\n", + "looking for paths in the network with length: 3 for node EGFR_Y1068 and SMAD3\n", + "looking for paths in the network with length: 4 for node EGFR_Y1068 and SMAD3\n", + "looking for paths in the network with length: 5 for node EGFR_Y1068 and SMAD3\n", + "looking for paths in the network with length: 6 for node EGFR_Y1068 and SMAD3\n", + "looking for paths in the network with length: 7 for node EGFR_Y1068 and SMAD3\n", + "looking for paths in the network with length: 8 for node EGFR_Y1068 and SMAD3\n", + "looking for paths in the network with length: 9 for node EGFR_Y1068 and SMAD3\n", + "looking for paths in the network with length: 10 for node EGFR_Y1068 and SMAD3\n", + "i_search = 4\n", + "Looking for paths with length: 0 for node EGFR_Y1068 and SMAD3\n", + "i_search = 4\n", + "Looking for paths with length: 1 for node EGFR_Y1068 and SMAD3\n", + "i_search = 4\n", + "Looking for paths with length: 2 for node EGFR_Y1068 and SMAD3\n", + "i_search = 4\n", + "Looking for paths with length: 3 for node EGFR_Y1068 and SMAD3\n", + "i_search = 4\n", + "Looking for paths with length: 4 for node EGFR_Y1068 and SMAD3\n", + "looking for paths in the network with length: 0 for node EGFR_Y1068 and TP53\n", + "looking for paths in the network with length: 1 for node EGFR_Y1068 and TP53\n", + "looking for paths in the network with length: 2 for node EGFR_Y1068 and TP53\n", + "looking for paths in the network with length: 3 for node EGFR_Y1068 and TP53\n", + "looking for paths in the network with length: 4 for node EGFR_Y1068 and TP53\n", + "looking for paths in the network with length: 5 for node EGFR_Y1068 and TP53\n", + "looking for paths in the network with length: 6 for node EGFR_Y1068 and TP53\n", + "looking for paths in the network with length: 7 for node EGFR_Y1068 and TP53\n", + "looking for paths in the network with length: 8 for node EGFR_Y1068 and TP53\n", + "looking for paths in the network with length: 9 for node EGFR_Y1068 and TP53\n", + "looking for paths in the network with length: 10 for node EGFR_Y1068 and TP53\n", + "i_search = 4\n", + "Looking for paths with length: 0 for node EGFR_Y1068 and TP53\n", + "i_search = 4\n", + "Looking for paths with length: 1 for node EGFR_Y1068 and TP53\n", + "i_search = 4\n", + "Looking for paths with length: 2 for node EGFR_Y1068 and TP53\n", + "i_search = 4\n", + "Looking for paths with length: 3 for node EGFR_Y1068 and TP53\n", + "i_search = 4\n", + "Looking for paths with length: 4 for node EGFR_Y1068 and TP53\n", + "looking for paths in the network with length: 0 for node EGFR_Y1068 and AKT1S1\n", + "looking for paths in the network with length: 1 for node EGFR_Y1068 and AKT1S1\n", + "looking for paths in the network with length: 2 for node EGFR_Y1068 and AKT1S1\n", + "looking for paths in the network with length: 3 for node EGFR_Y1068 and AKT1S1\n", + "looking for paths in the network with length: 4 for node EGFR_Y1068 and AKT1S1\n", + "looking for paths in the network with length: 5 for node EGFR_Y1068 and AKT1S1\n", + "looking for paths in the network with length: 6 for node EGFR_Y1068 and AKT1S1\n", + "looking for paths in the network with length: 7 for node EGFR_Y1068 and AKT1S1\n", + "looking for paths in the network with length: 8 for node EGFR_Y1068 and AKT1S1\n", + "looking for paths in the network with length: 9 for node EGFR_Y1068 and AKT1S1\n", + "looking for paths in the network with length: 10 for node EGFR_Y1068 and AKT1S1\n", + "i_search = 4\n", + "Looking for paths with length: 0 for node EGFR_Y1068 and AKT1S1\n", + "i_search = 4\n", + "Looking for paths with length: 1 for node EGFR_Y1068 and AKT1S1\n", + "i_search = 4\n", + "Looking for paths with length: 2 for node EGFR_Y1068 and AKT1S1\n", + "i_search = 4\n", + "Looking for paths with length: 3 for node EGFR_Y1068 and AKT1S1\n", + "i_search = 4\n", + "Looking for paths with length: 4 for node EGFR_Y1068 and AKT1S1\n", + "looking for paths in the network with length: 0 for node EGFR_Y1068 and GSK3B\n", + "looking for paths in the network with length: 1 for node EGFR_Y1068 and GSK3B\n", + "looking for paths in the network with length: 2 for node EGFR_Y1068 and GSK3B\n", + "looking for paths in the network with length: 3 for node EGFR_Y1068 and GSK3B\n", + "looking for paths in the network with length: 4 for node EGFR_Y1068 and GSK3B\n", + "looking for paths in the network with length: 5 for node EGFR_Y1068 and GSK3B\n", + "looking for paths in the network with length: 6 for node EGFR_Y1068 and GSK3B\n", + "looking for paths in the network with length: 7 for node EGFR_Y1068 and GSK3B\n", + "looking for paths in the network with length: 8 for node EGFR_Y1068 and GSK3B\n", + "looking for paths in the network with length: 9 for node EGFR_Y1068 and GSK3B\n", + "looking for paths in the network with length: 10 for node EGFR_Y1068 and GSK3B\n", + "i_search = 4\n", + "Looking for paths with length: 0 for node EGFR_Y1068 and GSK3B\n", + "i_search = 4\n", + "Looking for paths with length: 1 for node EGFR_Y1068 and GSK3B\n", + "i_search = 4\n", + "Looking for paths with length: 2 for node EGFR_Y1068 and GSK3B\n", + "i_search = 4\n", + "Looking for paths with length: 3 for node EGFR_Y1068 and GSK3B\n", + "i_search = 4\n", + "Looking for paths with length: 4 for node EGFR_Y1068 and GSK3B\n", + "looking for paths in the network with length: 0 for node EGFR_Y1068 and AKT1\n", + "looking for paths in the network with length: 1 for node EGFR_Y1068 and AKT1\n", + "looking for paths in the network with length: 2 for node EGFR_Y1068 and AKT1\n", + "looking for paths in the network with length: 3 for node EGFR_Y1068 and AKT1\n", + "looking for paths in the network with length: 4 for node EGFR_Y1068 and AKT1\n", + "looking for paths in the network with length: 5 for node EGFR_Y1068 and AKT1\n", + "looking for paths in the network with length: 6 for node EGFR_Y1068 and AKT1\n", + "looking for paths in the network with length: 7 for node EGFR_Y1068 and AKT1\n", + "looking for paths in the network with length: 8 for node EGFR_Y1068 and AKT1\n", + "looking for paths in the network with length: 9 for node EGFR_Y1068 and AKT1\n", + "looking for paths in the network with length: 10 for node EGFR_Y1068 and AKT1\n", + "i_search = 4\n", + "Looking for paths with length: 0 for node EGFR_Y1068 and AKT1\n", + "i_search = 4\n", + "Looking for paths with length: 1 for node EGFR_Y1068 and AKT1\n", + "i_search = 4\n", + "Looking for paths with length: 2 for node EGFR_Y1068 and AKT1\n", + "i_search = 4\n", + "Looking for paths with length: 3 for node EGFR_Y1068 and AKT1\n", + "i_search = 4\n", + "Looking for paths with length: 4 for node EGFR_Y1068 and AKT1\n", + "looking for paths in the network with length: 0 for node EGFR_Y1068 and HSPB1\n", + "looking for paths in the network with length: 1 for node EGFR_Y1068 and HSPB1\n", + "looking for paths in the network with length: 2 for node EGFR_Y1068 and HSPB1\n", + "looking for paths in the network with length: 3 for node EGFR_Y1068 and HSPB1\n", + "looking for paths in the network with length: 4 for node EGFR_Y1068 and HSPB1\n", + "looking for paths in the network with length: 5 for node EGFR_Y1068 and HSPB1\n", + "looking for paths in the network with length: 6 for node EGFR_Y1068 and HSPB1\n", + "looking for paths in the network with length: 7 for node EGFR_Y1068 and HSPB1\n", + "looking for paths in the network with length: 8 for node EGFR_Y1068 and HSPB1\n", + "looking for paths in the network with length: 9 for node EGFR_Y1068 and HSPB1\n", + "looking for paths in the network with length: 10 for node EGFR_Y1068 and HSPB1\n", + "i_search = 4\n", + "Looking for paths with length: 0 for node EGFR_Y1068 and HSPB1\n", + "i_search = 4\n", + "Looking for paths with length: 1 for node EGFR_Y1068 and HSPB1\n", + "i_search = 4\n", + "Looking for paths with length: 2 for node EGFR_Y1068 and HSPB1\n", + "i_search = 4\n", + "Looking for paths with length: 3 for node EGFR_Y1068 and HSPB1\n", + "i_search = 4\n", + "Looking for paths with length: 4 for node EGFR_Y1068 and HSPB1\n", + "looking for paths in the network with length: 0 for node EGFR_Y1068 and MAPK14\n", + "looking for paths in the network with length: 1 for node EGFR_Y1068 and MAPK14\n", + "looking for paths in the network with length: 2 for node EGFR_Y1068 and MAPK14\n", + "looking for paths in the network with length: 3 for node EGFR_Y1068 and MAPK14\n", + "looking for paths in the network with length: 4 for node EGFR_Y1068 and MAPK14\n", + "looking for paths in the network with length: 5 for node EGFR_Y1068 and MAPK14\n", + "looking for paths in the network with length: 6 for node EGFR_Y1068 and MAPK14\n", + "looking for paths in the network with length: 7 for node EGFR_Y1068 and MAPK14\n", + "looking for paths in the network with length: 8 for node EGFR_Y1068 and MAPK14\n", + "looking for paths in the network with length: 9 for node EGFR_Y1068 and MAPK14\n", + "looking for paths in the network with length: 10 for node EGFR_Y1068 and MAPK14\n", + "i_search = 4\n", + "Looking for paths with length: 0 for node EGFR_Y1068 and MAPK14\n", + "i_search = 4\n", + "Looking for paths with length: 1 for node EGFR_Y1068 and MAPK14\n", + "i_search = 4\n", + "Looking for paths with length: 2 for node EGFR_Y1068 and MAPK14\n", + "i_search = 4\n", + "Looking for paths with length: 3 for node EGFR_Y1068 and MAPK14\n", + "i_search = 4\n", + "Looking for paths with length: 4 for node EGFR_Y1068 and MAPK14\n", + "looking for paths in the network with length: 0 for node EGFR_Y1068 and MAP2K1\n", + "looking for paths in the network with length: 1 for node EGFR_Y1068 and MAP2K1\n", + "looking for paths in the network with length: 2 for node EGFR_Y1068 and MAP2K1\n", + "looking for paths in the network with length: 3 for node EGFR_Y1068 and MAP2K1\n", + "looking for paths in the network with length: 4 for node EGFR_Y1068 and MAP2K1\n", + "looking for paths in the network with length: 5 for node EGFR_Y1068 and MAP2K1\n", + "looking for paths in the network with length: 6 for node EGFR_Y1068 and MAP2K1\n", + "looking for paths in the network with length: 7 for node EGFR_Y1068 and MAP2K1\n", + "looking for paths in the network with length: 8 for node EGFR_Y1068 and MAP2K1\n", + "looking for paths in the network with length: 9 for node EGFR_Y1068 and MAP2K1\n", + "looking for paths in the network with length: 10 for node EGFR_Y1068 and MAP2K1\n", + "i_search = 4\n", + "Looking for paths with length: 0 for node EGFR_Y1068 and MAP2K1\n", + "i_search = 4\n", + "Looking for paths with length: 1 for node EGFR_Y1068 and MAP2K1\n", + "i_search = 4\n", + "Looking for paths with length: 2 for node EGFR_Y1068 and MAP2K1\n", + "i_search = 4\n", + "Looking for paths with length: 3 for node EGFR_Y1068 and MAP2K1\n", + "i_search = 4\n", + "Looking for paths with length: 4 for node EGFR_Y1068 and MAP2K1\n", + "looking for paths in the network with length: 0 for node EGFR_Y1068 and RPS6KA1\n", + "looking for paths in the network with length: 1 for node EGFR_Y1068 and RPS6KA1\n", + "looking for paths in the network with length: 2 for node EGFR_Y1068 and RPS6KA1\n", + "looking for paths in the network with length: 3 for node EGFR_Y1068 and RPS6KA1\n", + "looking for paths in the network with length: 4 for node EGFR_Y1068 and RPS6KA1\n", + "looking for paths in the network with length: 5 for node EGFR_Y1068 and RPS6KA1\n", + "looking for paths in the network with length: 6 for node EGFR_Y1068 and RPS6KA1\n", + "looking for paths in the network with length: 7 for node EGFR_Y1068 and RPS6KA1\n", + "looking for paths in the network with length: 8 for node EGFR_Y1068 and RPS6KA1\n", + "looking for paths in the network with length: 9 for node EGFR_Y1068 and RPS6KA1\n", + "looking for paths in the network with length: 10 for node EGFR_Y1068 and RPS6KA1\n", + "i_search = 4\n", + "Looking for paths with length: 0 for node EGFR_Y1068 and RPS6KA1\n", + "i_search = 4\n", + "Looking for paths with length: 1 for node EGFR_Y1068 and RPS6KA1\n", + "i_search = 4\n", + "Looking for paths with length: 2 for node EGFR_Y1068 and RPS6KA1\n", + "i_search = 4\n", + "Looking for paths with length: 3 for node EGFR_Y1068 and RPS6KA1\n", + "i_search = 4\n", + "Looking for paths with length: 4 for node EGFR_Y1068 and RPS6KA1\n", + "looking for paths in the network with length: 0 for node EGFR_Y1068 and CREB1\n", + "looking for paths in the network with length: 1 for node EGFR_Y1068 and CREB1\n", + "looking for paths in the network with length: 2 for node EGFR_Y1068 and CREB1\n", + "looking for paths in the network with length: 3 for node EGFR_Y1068 and CREB1\n", + "looking for paths in the network with length: 4 for node EGFR_Y1068 and CREB1\n", + "looking for paths in the network with length: 5 for node EGFR_Y1068 and CREB1\n", + "looking for paths in the network with length: 6 for node EGFR_Y1068 and CREB1\n", + "looking for paths in the network with length: 7 for node EGFR_Y1068 and CREB1\n", + "looking for paths in the network with length: 8 for node EGFR_Y1068 and CREB1\n", + "looking for paths in the network with length: 9 for node EGFR_Y1068 and CREB1\n", + "looking for paths in the network with length: 10 for node EGFR_Y1068 and CREB1\n", + "i_search = 4\n", + "Looking for paths with length: 0 for node EGFR_Y1068 and CREB1\n", + "i_search = 4\n", + "Looking for paths with length: 1 for node EGFR_Y1068 and CREB1\n", + "i_search = 4\n", + "Looking for paths with length: 2 for node EGFR_Y1068 and CREB1\n", + "i_search = 4\n", + "Looking for paths with length: 3 for node EGFR_Y1068 and CREB1\n", + "i_search = 4\n", + "Looking for paths with length: 4 for node EGFR_Y1068 and CREB1\n", + "looking for paths in the network with length: 0 for node EGFR_Y1068 and NFKBIA\n", + "looking for paths in the network with length: 1 for node EGFR_Y1068 and NFKBIA\n", + "looking for paths in the network with length: 2 for node EGFR_Y1068 and NFKBIA\n", + "looking for paths in the network with length: 3 for node EGFR_Y1068 and NFKBIA\n", + "looking for paths in the network with length: 4 for node EGFR_Y1068 and NFKBIA\n", + "looking for paths in the network with length: 5 for node EGFR_Y1068 and NFKBIA\n", + "looking for paths in the network with length: 6 for node EGFR_Y1068 and NFKBIA\n", + "looking for paths in the network with length: 7 for node EGFR_Y1068 and NFKBIA\n", + "looking for paths in the network with length: 8 for node EGFR_Y1068 and NFKBIA\n", + "looking for paths in the network with length: 9 for node EGFR_Y1068 and NFKBIA\n", + "looking for paths in the network with length: 10 for node EGFR_Y1068 and NFKBIA\n", + "i_search = 4\n", + "Looking for paths with length: 0 for node EGFR_Y1068 and NFKBIA\n", + "i_search = 4\n", + "Looking for paths with length: 1 for node EGFR_Y1068 and NFKBIA\n", + "i_search = 4\n", + "Looking for paths with length: 2 for node EGFR_Y1068 and NFKBIA\n", + "i_search = 4\n", + "Looking for paths with length: 3 for node EGFR_Y1068 and NFKBIA\n", + "i_search = 4\n", + "Looking for paths with length: 4 for node EGFR_Y1068 and NFKBIA\n", + "looking for paths in the network with length: 0 for node EGFR_Y1068 and MTOR\n", + "looking for paths in the network with length: 1 for node EGFR_Y1068 and MTOR\n", + "looking for paths in the network with length: 2 for node EGFR_Y1068 and MTOR\n", + "looking for paths in the network with length: 3 for node EGFR_Y1068 and MTOR\n", + "looking for paths in the network with length: 4 for node EGFR_Y1068 and MTOR\n", + "looking for paths in the network with length: 5 for node EGFR_Y1068 and MTOR\n", + "looking for paths in the network with length: 6 for node EGFR_Y1068 and MTOR\n", + "looking for paths in the network with length: 7 for node EGFR_Y1068 and MTOR\n", + "looking for paths in the network with length: 8 for node EGFR_Y1068 and MTOR\n", + "looking for paths in the network with length: 9 for node EGFR_Y1068 and MTOR\n", + "looking for paths in the network with length: 10 for node EGFR_Y1068 and MTOR\n", + "i_search = 4\n", + "Looking for paths with length: 0 for node EGFR_Y1068 and MTOR\n", + "i_search = 4\n", + "Looking for paths with length: 1 for node EGFR_Y1068 and MTOR\n", + "i_search = 4\n", + "Looking for paths with length: 2 for node EGFR_Y1068 and MTOR\n", + "i_search = 4\n", + "Looking for paths with length: 3 for node EGFR_Y1068 and MTOR\n", + "i_search = 4\n", + "Looking for paths with length: 4 for node EGFR_Y1068 and MTOR\n", + "looking for paths in the network with length: 0 for node EGFR_Y1068 and JUN\n", + "looking for paths in the network with length: 1 for node EGFR_Y1068 and JUN\n", + "looking for paths in the network with length: 2 for node EGFR_Y1068 and JUN\n", + "looking for paths in the network with length: 3 for node EGFR_Y1068 and JUN\n", + "looking for paths in the network with length: 4 for node EGFR_Y1068 and JUN\n", + "looking for paths in the network with length: 5 for node EGFR_Y1068 and JUN\n", + "looking for paths in the network with length: 6 for node EGFR_Y1068 and JUN\n", + "looking for paths in the network with length: 7 for node EGFR_Y1068 and JUN\n", + "looking for paths in the network with length: 8 for node EGFR_Y1068 and JUN\n", + "looking for paths in the network with length: 9 for node EGFR_Y1068 and JUN\n", + "looking for paths in the network with length: 10 for node EGFR_Y1068 and JUN\n", + "i_search = 4\n", + "Looking for paths with length: 0 for node EGFR_Y1068 and JUN\n", + "i_search = 4\n", + "Looking for paths with length: 1 for node EGFR_Y1068 and JUN\n", + "i_search = 4\n", + "Looking for paths with length: 2 for node EGFR_Y1068 and JUN\n", + "i_search = 4\n", + "Looking for paths with length: 3 for node EGFR_Y1068 and JUN\n", + "i_search = 4\n", + "Looking for paths with length: 4 for node EGFR_Y1068 and JUN\n", + "looking for paths in the network with length: 0 for node EGFR_Y1068 and EGFR\n", + "looking for paths in the network with length: 1 for node EGFR_Y1068 and EGFR\n", + "looking for paths in the network with length: 2 for node EGFR_Y1068 and EGFR\n", + "looking for paths in the network with length: 3 for node EGFR_Y1068 and EGFR\n", + "looking for paths in the network with length: 4 for node EGFR_Y1068 and EGFR\n", + "looking for paths in the network with length: 5 for node EGFR_Y1068 and EGFR\n", + "looking for paths in the network with length: 6 for node EGFR_Y1068 and EGFR\n", + "looking for paths in the network with length: 7 for node EGFR_Y1068 and EGFR\n", + "looking for paths in the network with length: 8 for node EGFR_Y1068 and EGFR\n", + "looking for paths in the network with length: 9 for node EGFR_Y1068 and EGFR\n", + "looking for paths in the network with length: 10 for node EGFR_Y1068 and EGFR\n", + "i_search = 4\n", + "Looking for paths with length: 0 for node EGFR_Y1068 and EGFR\n", + "i_search = 4\n", + "Looking for paths with length: 1 for node EGFR_Y1068 and EGFR\n", + "i_search = 4\n", + "Looking for paths with length: 2 for node EGFR_Y1068 and EGFR\n", + "i_search = 4\n", + "Looking for paths with length: 3 for node EGFR_Y1068 and EGFR\n", + "i_search = 4\n", + "Looking for paths with length: 4 for node EGFR_Y1068 and EGFR\n", + "looking for paths in the network with length: 0 for node EGFR_Y1068 and MAPK3\n", + "looking for paths in the network with length: 1 for node EGFR_Y1068 and MAPK3\n", + "looking for paths in the network with length: 2 for node EGFR_Y1068 and MAPK3\n", + "looking for paths in the network with length: 3 for node EGFR_Y1068 and MAPK3\n", + "looking for paths in the network with length: 4 for node EGFR_Y1068 and MAPK3\n", + "looking for paths in the network with length: 5 for node EGFR_Y1068 and MAPK3\n", + "looking for paths in the network with length: 6 for node EGFR_Y1068 and MAPK3\n", + "looking for paths in the network with length: 7 for node EGFR_Y1068 and MAPK3\n", + "looking for paths in the network with length: 8 for node EGFR_Y1068 and MAPK3\n", + "looking for paths in the network with length: 9 for node EGFR_Y1068 and MAPK3\n", + "looking for paths in the network with length: 10 for node EGFR_Y1068 and MAPK3\n", + "i_search = 4\n", + "Looking for paths with length: 0 for node EGFR_Y1068 and MAPK3\n", + "i_search = 4\n", + "Looking for paths with length: 1 for node EGFR_Y1068 and MAPK3\n", + "i_search = 4\n", + "Looking for paths with length: 2 for node EGFR_Y1068 and MAPK3\n", + "i_search = 4\n", + "Looking for paths with length: 3 for node EGFR_Y1068 and MAPK3\n", + "i_search = 4\n", + "Looking for paths with length: 4 for node EGFR_Y1068 and MAPK3\n", + "looking for paths in the network with length: 0 for node EGFR_Y1068 and PTPN11\n", + "looking for paths in the network with length: 1 for node EGFR_Y1068 and PTPN11\n", + "looking for paths in the network with length: 2 for node EGFR_Y1068 and PTPN11\n", + "looking for paths in the network with length: 3 for node EGFR_Y1068 and PTPN11\n", + "looking for paths in the network with length: 4 for node EGFR_Y1068 and PTPN11\n", + "looking for paths in the network with length: 5 for node EGFR_Y1068 and PTPN11\n", + "looking for paths in the network with length: 6 for node EGFR_Y1068 and PTPN11\n", + "looking for paths in the network with length: 7 for node EGFR_Y1068 and PTPN11\n", + "looking for paths in the network with length: 8 for node EGFR_Y1068 and PTPN11\n", + "looking for paths in the network with length: 9 for node EGFR_Y1068 and PTPN11\n", + "looking for paths in the network with length: 10 for node EGFR_Y1068 and PTPN11\n", + "i_search = 4\n", + "Looking for paths with length: 0 for node EGFR_Y1068 and PTPN11\n", + "i_search = 4\n", + "Looking for paths with length: 1 for node EGFR_Y1068 and PTPN11\n", + "i_search = 4\n", + "Looking for paths with length: 2 for node EGFR_Y1068 and PTPN11\n", + "i_search = 4\n", + "Looking for paths with length: 3 for node EGFR_Y1068 and PTPN11\n", + "i_search = 4\n", + "Looking for paths with length: 4 for node EGFR_Y1068 and PTPN11\n", + "looking for paths in the network with length: 0 for node EGFR_Y1068 and STAT3\n", + "looking for paths in the network with length: 1 for node EGFR_Y1068 and STAT3\n", + "looking for paths in the network with length: 2 for node EGFR_Y1068 and STAT3\n", + "looking for paths in the network with length: 3 for node EGFR_Y1068 and STAT3\n", + "looking for paths in the network with length: 4 for node EGFR_Y1068 and STAT3\n", + "looking for paths in the network with length: 5 for node EGFR_Y1068 and STAT3\n", + "looking for paths in the network with length: 6 for node EGFR_Y1068 and STAT3\n", + "looking for paths in the network with length: 7 for node EGFR_Y1068 and STAT3\n", + "looking for paths in the network with length: 8 for node EGFR_Y1068 and STAT3\n", + "looking for paths in the network with length: 9 for node EGFR_Y1068 and STAT3\n", + "looking for paths in the network with length: 10 for node EGFR_Y1068 and STAT3\n", + "i_search = 4\n", + "Looking for paths with length: 0 for node EGFR_Y1068 and STAT3\n", + "i_search = 4\n", + "Looking for paths with length: 1 for node EGFR_Y1068 and STAT3\n", + "i_search = 4\n", + "Looking for paths with length: 2 for node EGFR_Y1068 and STAT3\n", + "i_search = 4\n", + "Looking for paths with length: 3 for node EGFR_Y1068 and STAT3\n", + "i_search = 4\n", + "Looking for paths with length: 4 for node EGFR_Y1068 and STAT3\n", + "looking for paths in the network with length: 0 for node EGFR_Y1068 and CHEK2\n", + "looking for paths in the network with length: 1 for node EGFR_Y1068 and CHEK2\n", + "looking for paths in the network with length: 2 for node EGFR_Y1068 and CHEK2\n", + "looking for paths in the network with length: 3 for node EGFR_Y1068 and CHEK2\n", + "looking for paths in the network with length: 4 for node EGFR_Y1068 and CHEK2\n", + "looking for paths in the network with length: 5 for node EGFR_Y1068 and CHEK2\n", + "looking for paths in the network with length: 6 for node EGFR_Y1068 and CHEK2\n", + "looking for paths in the network with length: 7 for node EGFR_Y1068 and CHEK2\n", + "looking for paths in the network with length: 8 for node EGFR_Y1068 and CHEK2\n", + "looking for paths in the network with length: 9 for node EGFR_Y1068 and CHEK2\n", + "looking for paths in the network with length: 10 for node EGFR_Y1068 and CHEK2\n", + "i_search = 4\n", + "Looking for paths with length: 0 for node EGFR_Y1068 and CHEK2\n", + "i_search = 4\n", + "Looking for paths with length: 1 for node EGFR_Y1068 and CHEK2\n", + "i_search = 4\n", + "Looking for paths with length: 2 for node EGFR_Y1068 and CHEK2\n", + "i_search = 4\n", + "Looking for paths with length: 3 for node EGFR_Y1068 and CHEK2\n", + "i_search = 4\n", + "Looking for paths with length: 4 for node EGFR_Y1068 and CHEK2\n", + "looking for paths in the network with length: 0 for node EGFR_Y1068 and RELA\n", + "looking for paths in the network with length: 1 for node EGFR_Y1068 and RELA\n", + "looking for paths in the network with length: 2 for node EGFR_Y1068 and RELA\n", + "looking for paths in the network with length: 3 for node EGFR_Y1068 and RELA\n", + "looking for paths in the network with length: 4 for node EGFR_Y1068 and RELA\n", + "looking for paths in the network with length: 5 for node EGFR_Y1068 and RELA\n", + "looking for paths in the network with length: 6 for node EGFR_Y1068 and RELA\n", + "looking for paths in the network with length: 7 for node EGFR_Y1068 and RELA\n", + "looking for paths in the network with length: 8 for node EGFR_Y1068 and RELA\n", + "looking for paths in the network with length: 9 for node EGFR_Y1068 and RELA\n", + "looking for paths in the network with length: 10 for node EGFR_Y1068 and RELA\n", + "i_search = 4\n", + "Looking for paths with length: 0 for node EGFR_Y1068 and RELA\n", + "i_search = 4\n", + "Looking for paths with length: 1 for node EGFR_Y1068 and RELA\n", + "i_search = 4\n", + "Looking for paths with length: 2 for node EGFR_Y1068 and RELA\n", + "i_search = 4\n", + "Looking for paths with length: 3 for node EGFR_Y1068 and RELA\n", + "i_search = 4\n", + "Looking for paths with length: 4 for node EGFR_Y1068 and RELA\n", + "looking for paths in the network with length: 0 for node EGFR_Y1068 and MARCKS\n", + "looking for paths in the network with length: 1 for node EGFR_Y1068 and MARCKS\n", + "looking for paths in the network with length: 2 for node EGFR_Y1068 and MARCKS\n", + "looking for paths in the network with length: 3 for node EGFR_Y1068 and MARCKS\n", + "looking for paths in the network with length: 4 for node EGFR_Y1068 and MARCKS\n", + "looking for paths in the network with length: 5 for node EGFR_Y1068 and MARCKS\n", + "looking for paths in the network with length: 6 for node EGFR_Y1068 and MARCKS\n", + "looking for paths in the network with length: 7 for node EGFR_Y1068 and MARCKS\n", + "looking for paths in the network with length: 8 for node EGFR_Y1068 and MARCKS\n", + "looking for paths in the network with length: 9 for node EGFR_Y1068 and MARCKS\n", + "looking for paths in the network with length: 10 for node EGFR_Y1068 and MARCKS\n", + "i_search = 4\n", + "Looking for paths with length: 0 for node EGFR_Y1068 and MARCKS\n", + "i_search = 4\n", + "Looking for paths with length: 1 for node EGFR_Y1068 and MARCKS\n", + "i_search = 4\n", + "Looking for paths with length: 2 for node EGFR_Y1068 and MARCKS\n", + "i_search = 4\n", + "Looking for paths with length: 3 for node EGFR_Y1068 and MARCKS\n", + "i_search = 4\n", + "Looking for paths with length: 4 for node EGFR_Y1068 and MARCKS\n", + "looking for paths in the network with length: 0 for node MAPK3_T202 and MAPK3_Y204\n", + "looking for paths in the network with length: 1 for node MAPK3_T202 and MAPK3_Y204\n", + "looking for paths in the network with length: 2 for node MAPK3_T202 and MAPK3_Y204\n", + "Found a path!\n", + "[['MAPK3_T202', 'MAPK3', 'MAPK3_Y204']]\n", + "looking for paths in the network with length: 0 for node MAPK3_T202 and PTPN11_Y542\n", + "looking for paths in the network with length: 1 for node MAPK3_T202 and PTPN11_Y542\n", + "looking for paths in the network with length: 2 for node MAPK3_T202 and PTPN11_Y542\n", + "looking for paths in the network with length: 3 for node MAPK3_T202 and PTPN11_Y542\n", + "looking for paths in the network with length: 4 for node MAPK3_T202 and PTPN11_Y542\n", + "looking for paths in the network with length: 5 for node MAPK3_T202 and PTPN11_Y542\n", + "looking for paths in the network with length: 6 for node MAPK3_T202 and PTPN11_Y542\n", + "looking for paths in the network with length: 7 for node MAPK3_T202 and PTPN11_Y542\n", + "looking for paths in the network with length: 8 for node MAPK3_T202 and PTPN11_Y542\n", + "looking for paths in the network with length: 9 for node MAPK3_T202 and PTPN11_Y542\n", + "looking for paths in the network with length: 10 for node MAPK3_T202 and PTPN11_Y542\n", + "i_search = 4\n", + "Looking for paths with length: 0 for node MAPK3_T202 and PTPN11_Y542\n", + "i_search = 4\n", + "Looking for paths with length: 1 for node MAPK3_T202 and PTPN11_Y542\n", + "i_search = 4\n", + "Looking for paths with length: 2 for node MAPK3_T202 and PTPN11_Y542\n", + "i_search = 4\n", + "Looking for paths with length: 3 for node MAPK3_T202 and PTPN11_Y542\n", + "i_search = 4\n", + "Looking for paths with length: 4 for node MAPK3_T202 and PTPN11_Y542\n", + "looking for paths in the network with length: 0 for node MAPK3_T202 and STAT3_Y705\n", + "looking for paths in the network with length: 1 for node MAPK3_T202 and STAT3_Y705\n", + "looking for paths in the network with length: 2 for node MAPK3_T202 and STAT3_Y705\n", + "looking for paths in the network with length: 3 for node MAPK3_T202 and STAT3_Y705\n", + "looking for paths in the network with length: 4 for node MAPK3_T202 and STAT3_Y705\n", + "looking for paths in the network with length: 5 for node MAPK3_T202 and STAT3_Y705\n", + "looking for paths in the network with length: 6 for node MAPK3_T202 and STAT3_Y705\n", + "Found a path!\n", + "[['MAPK3_T202', 'MAPK3', 'GSK3B_T43', 'GSK3B', 'SRC_S493', 'SRC', 'STAT3_Y705'], ['MAPK3_T202', 'MAPK3', 'GSK3B_T43', 'GSK3B', 'SRC_S51', 'SRC', 'STAT3_Y705'], ['MAPK3_T202', 'MAPK3', 'GSK3B_T43', 'GSK3B', 'SRC_S43', 'SRC', 'STAT3_Y705'], ['MAPK3_T202', 'MAPK3', 'GSK3B_T43', 'GSK3B', 'SRC_Y419', 'SRC', 'STAT3_Y705']]\n", + "looking for paths in the network with length: 0 for node MAPK3_T202 and CHEK2_T68\n", + "looking for paths in the network with length: 1 for node MAPK3_T202 and CHEK2_T68\n", + "looking for paths in the network with length: 2 for node MAPK3_T202 and CHEK2_T68\n", + "looking for paths in the network with length: 3 for node MAPK3_T202 and CHEK2_T68\n", + "looking for paths in the network with length: 4 for node MAPK3_T202 and CHEK2_T68\n", + "looking for paths in the network with length: 5 for node MAPK3_T202 and CHEK2_T68\n", + "looking for paths in the network with length: 6 for node MAPK3_T202 and CHEK2_T68\n", + "looking for paths in the network with length: 7 for node MAPK3_T202 and CHEK2_T68\n", + "looking for paths in the network with length: 8 for node MAPK3_T202 and CHEK2_T68\n", + "looking for paths in the network with length: 9 for node MAPK3_T202 and CHEK2_T68\n", + "looking for paths in the network with length: 10 for node MAPK3_T202 and CHEK2_T68\n", + "i_search = 4\n", + "Looking for paths with length: 0 for node MAPK3_T202 and CHEK2_T68\n", + "i_search = 4\n", + "Looking for paths with length: 1 for node MAPK3_T202 and CHEK2_T68\n", + "i_search = 4\n", + "Looking for paths with length: 2 for node MAPK3_T202 and CHEK2_T68\n", + "i_search = 4\n", + "Looking for paths with length: 3 for node MAPK3_T202 and CHEK2_T68\n", + "i_search = 4\n", + "Looking for paths with length: 4 for node MAPK3_T202 and CHEK2_T68\n", + "looking for paths in the network with length: 0 for node MAPK3_T202 and RELA_S536\n", + "looking for paths in the network with length: 1 for node MAPK3_T202 and RELA_S536\n", + "looking for paths in the network with length: 2 for node MAPK3_T202 and RELA_S536\n", + "looking for paths in the network with length: 3 for node MAPK3_T202 and RELA_S536\n", + "looking for paths in the network with length: 4 for node MAPK3_T202 and RELA_S536\n", + "looking for paths in the network with length: 5 for node MAPK3_T202 and RELA_S536\n", + "looking for paths in the network with length: 6 for node MAPK3_T202 and RELA_S536\n", + "Found a path!\n", + "[['MAPK3_T202', 'MAPK3', 'GSK3B_T43', 'GSK3B', 'TBK1_S172', 'TBK1', 'RELA_S536']]\n", + "looking for paths in the network with length: 0 for node MAPK3_T202 and MARCKS_S170\n", + "looking for paths in the network with length: 1 for node MAPK3_T202 and MARCKS_S170\n", + "looking for paths in the network with length: 2 for node MAPK3_T202 and MARCKS_S170\n", + "looking for paths in the network with length: 3 for node MAPK3_T202 and MARCKS_S170\n", + "looking for paths in the network with length: 4 for node MAPK3_T202 and MARCKS_S170\n", + "looking for paths in the network with length: 5 for node MAPK3_T202 and MARCKS_S170\n", + "looking for paths in the network with length: 6 for node MAPK3_T202 and MARCKS_S170\n", + "looking for paths in the network with length: 7 for node MAPK3_T202 and MARCKS_S170\n", + "looking for paths in the network with length: 8 for node MAPK3_T202 and MARCKS_S170\n", + "looking for paths in the network with length: 9 for node MAPK3_T202 and MARCKS_S170\n", + "looking for paths in the network with length: 10 for node MAPK3_T202 and MARCKS_S170\n", + "i_search = 4\n", + "Looking for paths with length: 0 for node MAPK3_T202 and MARCKS_S170\n", + "i_search = 4\n", + "Looking for paths with length: 1 for node MAPK3_T202 and MARCKS_S170\n", + "i_search = 4\n", + "Looking for paths with length: 2 for node MAPK3_T202 and MARCKS_S170\n", + "i_search = 4\n", + "Looking for paths with length: 3 for node MAPK3_T202 and MARCKS_S170\n", + "i_search = 4\n", + "Looking for paths with length: 4 for node MAPK3_T202 and MARCKS_S170\n", + "looking for paths in the network with length: 0 for node MAPK3_T202 and SMAD3\n", + "looking for paths in the network with length: 1 for node MAPK3_T202 and SMAD3\n", + "looking for paths in the network with length: 2 for node MAPK3_T202 and SMAD3\n", + "looking for paths in the network with length: 3 for node MAPK3_T202 and SMAD3\n", + "looking for paths in the network with length: 4 for node MAPK3_T202 and SMAD3\n", + "looking for paths in the network with length: 5 for node MAPK3_T202 and SMAD3\n", + "looking for paths in the network with length: 6 for node MAPK3_T202 and SMAD3\n", + "looking for paths in the network with length: 7 for node MAPK3_T202 and SMAD3\n", + "looking for paths in the network with length: 8 for node MAPK3_T202 and SMAD3\n", + "looking for paths in the network with length: 9 for node MAPK3_T202 and SMAD3\n", + "looking for paths in the network with length: 10 for node MAPK3_T202 and SMAD3\n", + "i_search = 4\n", + "Looking for paths with length: 0 for node MAPK3_T202 and SMAD3\n", + "i_search = 4\n", + "Looking for paths with length: 1 for node MAPK3_T202 and SMAD3\n", + "i_search = 4\n", + "Looking for paths with length: 2 for node MAPK3_T202 and SMAD3\n", + "i_search = 4\n", + "Looking for paths with length: 3 for node MAPK3_T202 and SMAD3\n", + "i_search = 4\n", + "Looking for paths with length: 4 for node MAPK3_T202 and SMAD3\n", + "looking for paths in the network with length: 0 for node MAPK3_T202 and TP53\n", + "looking for paths in the network with length: 1 for node MAPK3_T202 and TP53\n", + "looking for paths in the network with length: 2 for node MAPK3_T202 and TP53\n", + "looking for paths in the network with length: 3 for node MAPK3_T202 and TP53\n", + "looking for paths in the network with length: 4 for node MAPK3_T202 and TP53\n", + "looking for paths in the network with length: 5 for node MAPK3_T202 and TP53\n", + "looking for paths in the network with length: 6 for node MAPK3_T202 and TP53\n", + "looking for paths in the network with length: 7 for node MAPK3_T202 and TP53\n", + "looking for paths in the network with length: 8 for node MAPK3_T202 and TP53\n", + "looking for paths in the network with length: 9 for node MAPK3_T202 and TP53\n", + "looking for paths in the network with length: 10 for node MAPK3_T202 and TP53\n", + "i_search = 4\n", + "Looking for paths with length: 0 for node MAPK3_T202 and TP53\n", + "i_search = 4\n", + "Looking for paths with length: 1 for node MAPK3_T202 and TP53\n", + "i_search = 4\n", + "Looking for paths with length: 2 for node MAPK3_T202 and TP53\n", + "i_search = 4\n", + "Looking for paths with length: 3 for node MAPK3_T202 and TP53\n", + "i_search = 4\n", + "Looking for paths with length: 4 for node MAPK3_T202 and TP53\n", + "looking for paths in the network with length: 0 for node MAPK3_T202 and AKT1S1\n", + "looking for paths in the network with length: 1 for node MAPK3_T202 and AKT1S1\n", + "looking for paths in the network with length: 2 for node MAPK3_T202 and AKT1S1\n", + "looking for paths in the network with length: 3 for node MAPK3_T202 and AKT1S1\n", + "looking for paths in the network with length: 4 for node MAPK3_T202 and AKT1S1\n", + "looking for paths in the network with length: 5 for node MAPK3_T202 and AKT1S1\n", + "looking for paths in the network with length: 6 for node MAPK3_T202 and AKT1S1\n", + "looking for paths in the network with length: 7 for node MAPK3_T202 and AKT1S1\n", + "looking for paths in the network with length: 8 for node MAPK3_T202 and AKT1S1\n", + "looking for paths in the network with length: 9 for node MAPK3_T202 and AKT1S1\n", + "looking for paths in the network with length: 10 for node MAPK3_T202 and AKT1S1\n", + "i_search = 4\n", + "Looking for paths with length: 0 for node MAPK3_T202 and AKT1S1\n", + "i_search = 4\n", + "Looking for paths with length: 1 for node MAPK3_T202 and AKT1S1\n", + "i_search = 4\n", + "Looking for paths with length: 2 for node MAPK3_T202 and AKT1S1\n", + "i_search = 4\n", + "Looking for paths with length: 3 for node MAPK3_T202 and AKT1S1\n", + "i_search = 4\n", + "Looking for paths with length: 4 for node MAPK3_T202 and AKT1S1\n", + "looking for paths in the network with length: 0 for node MAPK3_T202 and GSK3B\n", + "looking for paths in the network with length: 1 for node MAPK3_T202 and GSK3B\n", + "looking for paths in the network with length: 2 for node MAPK3_T202 and GSK3B\n", + "looking for paths in the network with length: 3 for node MAPK3_T202 and GSK3B\n", + "looking for paths in the network with length: 4 for node MAPK3_T202 and GSK3B\n", + "looking for paths in the network with length: 5 for node MAPK3_T202 and GSK3B\n", + "looking for paths in the network with length: 6 for node MAPK3_T202 and GSK3B\n", + "looking for paths in the network with length: 7 for node MAPK3_T202 and GSK3B\n", + "looking for paths in the network with length: 8 for node MAPK3_T202 and GSK3B\n", + "looking for paths in the network with length: 9 for node MAPK3_T202 and GSK3B\n", + "looking for paths in the network with length: 10 for node MAPK3_T202 and GSK3B\n", + "i_search = 4\n", + "Looking for paths with length: 0 for node MAPK3_T202 and GSK3B\n", + "i_search = 4\n", + "Looking for paths with length: 1 for node MAPK3_T202 and GSK3B\n", + "i_search = 4\n", + "Looking for paths with length: 2 for node MAPK3_T202 and GSK3B\n", + "i_search = 4\n", + "Looking for paths with length: 3 for node MAPK3_T202 and GSK3B\n", + "i_search = 4\n", + "Looking for paths with length: 4 for node MAPK3_T202 and GSK3B\n", + "looking for paths in the network with length: 0 for node MAPK3_T202 and AKT1\n", + "looking for paths in the network with length: 1 for node MAPK3_T202 and AKT1\n", + "looking for paths in the network with length: 2 for node MAPK3_T202 and AKT1\n", + "looking for paths in the network with length: 3 for node MAPK3_T202 and AKT1\n", + "looking for paths in the network with length: 4 for node MAPK3_T202 and AKT1\n", + "looking for paths in the network with length: 5 for node MAPK3_T202 and AKT1\n", + "looking for paths in the network with length: 6 for node MAPK3_T202 and AKT1\n", + "looking for paths in the network with length: 7 for node MAPK3_T202 and AKT1\n", + "looking for paths in the network with length: 8 for node MAPK3_T202 and AKT1\n", + "looking for paths in the network with length: 9 for node MAPK3_T202 and AKT1\n", + "looking for paths in the network with length: 10 for node MAPK3_T202 and AKT1\n", + "i_search = 4\n", + "Looking for paths with length: 0 for node MAPK3_T202 and AKT1\n", + "i_search = 4\n", + "Looking for paths with length: 1 for node MAPK3_T202 and AKT1\n", + "i_search = 4\n", + "Looking for paths with length: 2 for node MAPK3_T202 and AKT1\n", + "i_search = 4\n", + "Looking for paths with length: 3 for node MAPK3_T202 and AKT1\n", + "i_search = 4\n", + "Looking for paths with length: 4 for node MAPK3_T202 and AKT1\n", + "looking for paths in the network with length: 0 for node MAPK3_T202 and HSPB1\n", + "looking for paths in the network with length: 1 for node MAPK3_T202 and HSPB1\n", + "looking for paths in the network with length: 2 for node MAPK3_T202 and HSPB1\n", + "looking for paths in the network with length: 3 for node MAPK3_T202 and HSPB1\n", + "looking for paths in the network with length: 4 for node MAPK3_T202 and HSPB1\n", + "looking for paths in the network with length: 5 for node MAPK3_T202 and HSPB1\n", + "looking for paths in the network with length: 6 for node MAPK3_T202 and HSPB1\n", + "looking for paths in the network with length: 7 for node MAPK3_T202 and HSPB1\n", + "looking for paths in the network with length: 8 for node MAPK3_T202 and HSPB1\n", + "looking for paths in the network with length: 9 for node MAPK3_T202 and HSPB1\n", + "looking for paths in the network with length: 10 for node MAPK3_T202 and HSPB1\n", + "i_search = 4\n", + "Looking for paths with length: 0 for node MAPK3_T202 and HSPB1\n", + "i_search = 4\n", + "Looking for paths with length: 1 for node MAPK3_T202 and HSPB1\n", + "i_search = 4\n", + "Looking for paths with length: 2 for node MAPK3_T202 and HSPB1\n", + "i_search = 4\n", + "Looking for paths with length: 3 for node MAPK3_T202 and HSPB1\n", + "i_search = 4\n", + "Looking for paths with length: 4 for node MAPK3_T202 and HSPB1\n", + "looking for paths in the network with length: 0 for node MAPK3_T202 and MAPK14\n", + "looking for paths in the network with length: 1 for node MAPK3_T202 and MAPK14\n", + "looking for paths in the network with length: 2 for node MAPK3_T202 and MAPK14\n", + "looking for paths in the network with length: 3 for node MAPK3_T202 and MAPK14\n", + "looking for paths in the network with length: 4 for node MAPK3_T202 and MAPK14\n", + "looking for paths in the network with length: 5 for node MAPK3_T202 and MAPK14\n", + "looking for paths in the network with length: 6 for node MAPK3_T202 and MAPK14\n", + "looking for paths in the network with length: 7 for node MAPK3_T202 and MAPK14\n", + "looking for paths in the network with length: 8 for node MAPK3_T202 and MAPK14\n", + "looking for paths in the network with length: 9 for node MAPK3_T202 and MAPK14\n", + "looking for paths in the network with length: 10 for node MAPK3_T202 and MAPK14\n", + "i_search = 4\n", + "Looking for paths with length: 0 for node MAPK3_T202 and MAPK14\n", + "i_search = 4\n", + "Looking for paths with length: 1 for node MAPK3_T202 and MAPK14\n", + "i_search = 4\n", + "Looking for paths with length: 2 for node MAPK3_T202 and MAPK14\n", + "i_search = 4\n", + "Looking for paths with length: 3 for node MAPK3_T202 and MAPK14\n", + "i_search = 4\n", + "Looking for paths with length: 4 for node MAPK3_T202 and MAPK14\n", + "looking for paths in the network with length: 0 for node MAPK3_T202 and MAP2K1\n", + "looking for paths in the network with length: 1 for node MAPK3_T202 and MAP2K1\n", + "looking for paths in the network with length: 2 for node MAPK3_T202 and MAP2K1\n", + "looking for paths in the network with length: 3 for node MAPK3_T202 and MAP2K1\n", + "looking for paths in the network with length: 4 for node MAPK3_T202 and MAP2K1\n", + "looking for paths in the network with length: 5 for node MAPK3_T202 and MAP2K1\n", + "looking for paths in the network with length: 6 for node MAPK3_T202 and MAP2K1\n", + "looking for paths in the network with length: 7 for node MAPK3_T202 and MAP2K1\n", + "looking for paths in the network with length: 8 for node MAPK3_T202 and MAP2K1\n", + "looking for paths in the network with length: 9 for node MAPK3_T202 and MAP2K1\n", + "looking for paths in the network with length: 10 for node MAPK3_T202 and MAP2K1\n", + "i_search = 4\n", + "Looking for paths with length: 0 for node MAPK3_T202 and MAP2K1\n", + "i_search = 4\n", + "Looking for paths with length: 1 for node MAPK3_T202 and MAP2K1\n", + "i_search = 4\n", + "Looking for paths with length: 2 for node MAPK3_T202 and MAP2K1\n", + "i_search = 4\n", + "Looking for paths with length: 3 for node MAPK3_T202 and MAP2K1\n", + "i_search = 4\n", + "Looking for paths with length: 4 for node MAPK3_T202 and MAP2K1\n", + "looking for paths in the network with length: 0 for node MAPK3_T202 and RPS6KA1\n", + "looking for paths in the network with length: 1 for node MAPK3_T202 and RPS6KA1\n", + "looking for paths in the network with length: 2 for node MAPK3_T202 and RPS6KA1\n", + "looking for paths in the network with length: 3 for node MAPK3_T202 and RPS6KA1\n", + "looking for paths in the network with length: 4 for node MAPK3_T202 and RPS6KA1\n", + "looking for paths in the network with length: 5 for node MAPK3_T202 and RPS6KA1\n", + "looking for paths in the network with length: 6 for node MAPK3_T202 and RPS6KA1\n", + "looking for paths in the network with length: 7 for node MAPK3_T202 and RPS6KA1\n", + "looking for paths in the network with length: 8 for node MAPK3_T202 and RPS6KA1\n", + "looking for paths in the network with length: 9 for node MAPK3_T202 and RPS6KA1\n", + "looking for paths in the network with length: 10 for node MAPK3_T202 and RPS6KA1\n", + "i_search = 4\n", + "Looking for paths with length: 0 for node MAPK3_T202 and RPS6KA1\n", + "i_search = 4\n", + "Looking for paths with length: 1 for node MAPK3_T202 and RPS6KA1\n", + "i_search = 4\n", + "Looking for paths with length: 2 for node MAPK3_T202 and RPS6KA1\n", + "i_search = 4\n", + "Looking for paths with length: 3 for node MAPK3_T202 and RPS6KA1\n", + "i_search = 4\n", + "Looking for paths with length: 4 for node MAPK3_T202 and RPS6KA1\n", + "looking for paths in the network with length: 0 for node MAPK3_T202 and CREB1\n", + "looking for paths in the network with length: 1 for node MAPK3_T202 and CREB1\n", + "looking for paths in the network with length: 2 for node MAPK3_T202 and CREB1\n", + "looking for paths in the network with length: 3 for node MAPK3_T202 and CREB1\n", + "looking for paths in the network with length: 4 for node MAPK3_T202 and CREB1\n", + "looking for paths in the network with length: 5 for node MAPK3_T202 and CREB1\n", + "looking for paths in the network with length: 6 for node MAPK3_T202 and CREB1\n", + "looking for paths in the network with length: 7 for node MAPK3_T202 and CREB1\n", + "looking for paths in the network with length: 8 for node MAPK3_T202 and CREB1\n", + "looking for paths in the network with length: 9 for node MAPK3_T202 and CREB1\n", + "looking for paths in the network with length: 10 for node MAPK3_T202 and CREB1\n", + "i_search = 4\n", + "Looking for paths with length: 0 for node MAPK3_T202 and CREB1\n", + "i_search = 4\n", + "Looking for paths with length: 1 for node MAPK3_T202 and CREB1\n", + "i_search = 4\n", + "Looking for paths with length: 2 for node MAPK3_T202 and CREB1\n", + "i_search = 4\n", + "Looking for paths with length: 3 for node MAPK3_T202 and CREB1\n", + "i_search = 4\n", + "Looking for paths with length: 4 for node MAPK3_T202 and CREB1\n", + "looking for paths in the network with length: 0 for node MAPK3_T202 and NFKBIA\n", + "looking for paths in the network with length: 1 for node MAPK3_T202 and NFKBIA\n", + "looking for paths in the network with length: 2 for node MAPK3_T202 and NFKBIA\n", + "looking for paths in the network with length: 3 for node MAPK3_T202 and NFKBIA\n", + "looking for paths in the network with length: 4 for node MAPK3_T202 and NFKBIA\n", + "looking for paths in the network with length: 5 for node MAPK3_T202 and NFKBIA\n", + "looking for paths in the network with length: 6 for node MAPK3_T202 and NFKBIA\n", + "looking for paths in the network with length: 7 for node MAPK3_T202 and NFKBIA\n", + "looking for paths in the network with length: 8 for node MAPK3_T202 and NFKBIA\n", + "looking for paths in the network with length: 9 for node MAPK3_T202 and NFKBIA\n", + "looking for paths in the network with length: 10 for node MAPK3_T202 and NFKBIA\n", + "i_search = 4\n", + "Looking for paths with length: 0 for node MAPK3_T202 and NFKBIA\n", + "i_search = 4\n", + "Looking for paths with length: 1 for node MAPK3_T202 and NFKBIA\n", + "i_search = 4\n", + "Looking for paths with length: 2 for node MAPK3_T202 and NFKBIA\n", + "i_search = 4\n", + "Looking for paths with length: 3 for node MAPK3_T202 and NFKBIA\n", + "i_search = 4\n", + "Looking for paths with length: 4 for node MAPK3_T202 and NFKBIA\n", + "looking for paths in the network with length: 0 for node MAPK3_T202 and MTOR\n", + "looking for paths in the network with length: 1 for node MAPK3_T202 and MTOR\n", + "looking for paths in the network with length: 2 for node MAPK3_T202 and MTOR\n", + "looking for paths in the network with length: 3 for node MAPK3_T202 and MTOR\n", + "looking for paths in the network with length: 4 for node MAPK3_T202 and MTOR\n", + "looking for paths in the network with length: 5 for node MAPK3_T202 and MTOR\n", + "looking for paths in the network with length: 6 for node MAPK3_T202 and MTOR\n", + "looking for paths in the network with length: 7 for node MAPK3_T202 and MTOR\n", + "looking for paths in the network with length: 8 for node MAPK3_T202 and MTOR\n", + "looking for paths in the network with length: 9 for node MAPK3_T202 and MTOR\n", + "looking for paths in the network with length: 10 for node MAPK3_T202 and MTOR\n", + "i_search = 4\n", + "Looking for paths with length: 0 for node MAPK3_T202 and MTOR\n", + "i_search = 4\n", + "Looking for paths with length: 1 for node MAPK3_T202 and MTOR\n", + "i_search = 4\n", + "Looking for paths with length: 2 for node MAPK3_T202 and MTOR\n", + "i_search = 4\n", + "Looking for paths with length: 3 for node MAPK3_T202 and MTOR\n", + "i_search = 4\n", + "Looking for paths with length: 4 for node MAPK3_T202 and MTOR\n", + "looking for paths in the network with length: 0 for node MAPK3_T202 and JUN\n", + "looking for paths in the network with length: 1 for node MAPK3_T202 and JUN\n", + "looking for paths in the network with length: 2 for node MAPK3_T202 and JUN\n", + "looking for paths in the network with length: 3 for node MAPK3_T202 and JUN\n", + "looking for paths in the network with length: 4 for node MAPK3_T202 and JUN\n", + "looking for paths in the network with length: 5 for node MAPK3_T202 and JUN\n", + "looking for paths in the network with length: 6 for node MAPK3_T202 and JUN\n", + "looking for paths in the network with length: 7 for node MAPK3_T202 and JUN\n", + "looking for paths in the network with length: 8 for node MAPK3_T202 and JUN\n", + "looking for paths in the network with length: 9 for node MAPK3_T202 and JUN\n", + "looking for paths in the network with length: 10 for node MAPK3_T202 and JUN\n", + "i_search = 4\n", + "Looking for paths with length: 0 for node MAPK3_T202 and JUN\n", + "i_search = 4\n", + "Looking for paths with length: 1 for node MAPK3_T202 and JUN\n", + "i_search = 4\n", + "Looking for paths with length: 2 for node MAPK3_T202 and JUN\n", + "i_search = 4\n", + "Looking for paths with length: 3 for node MAPK3_T202 and JUN\n", + "i_search = 4\n", + "Looking for paths with length: 4 for node MAPK3_T202 and JUN\n", + "looking for paths in the network with length: 0 for node MAPK3_T202 and EGFR\n", + "looking for paths in the network with length: 1 for node MAPK3_T202 and EGFR\n", + "looking for paths in the network with length: 2 for node MAPK3_T202 and EGFR\n", + "looking for paths in the network with length: 3 for node MAPK3_T202 and EGFR\n", + "looking for paths in the network with length: 4 for node MAPK3_T202 and EGFR\n", + "looking for paths in the network with length: 5 for node MAPK3_T202 and EGFR\n", + "looking for paths in the network with length: 6 for node MAPK3_T202 and EGFR\n", + "looking for paths in the network with length: 7 for node MAPK3_T202 and EGFR\n", + "looking for paths in the network with length: 8 for node MAPK3_T202 and EGFR\n", + "looking for paths in the network with length: 9 for node MAPK3_T202 and EGFR\n", + "looking for paths in the network with length: 10 for node MAPK3_T202 and EGFR\n", + "i_search = 4\n", + "Looking for paths with length: 0 for node MAPK3_T202 and EGFR\n", + "i_search = 4\n", + "Looking for paths with length: 1 for node MAPK3_T202 and EGFR\n", + "i_search = 4\n", + "Looking for paths with length: 2 for node MAPK3_T202 and EGFR\n", + "i_search = 4\n", + "Looking for paths with length: 3 for node MAPK3_T202 and EGFR\n", + "i_search = 4\n", + "Looking for paths with length: 4 for node MAPK3_T202 and EGFR\n", + "looking for paths in the network with length: 0 for node MAPK3_T202 and MAPK3\n", + "looking for paths in the network with length: 1 for node MAPK3_T202 and MAPK3\n", + "looking for paths in the network with length: 2 for node MAPK3_T202 and MAPK3\n", + "looking for paths in the network with length: 3 for node MAPK3_T202 and MAPK3\n", + "looking for paths in the network with length: 4 for node MAPK3_T202 and MAPK3\n", + "looking for paths in the network with length: 5 for node MAPK3_T202 and MAPK3\n", + "looking for paths in the network with length: 6 for node MAPK3_T202 and MAPK3\n", + "looking for paths in the network with length: 7 for node MAPK3_T202 and MAPK3\n", + "looking for paths in the network with length: 8 for node MAPK3_T202 and MAPK3\n", + "looking for paths in the network with length: 9 for node MAPK3_T202 and MAPK3\n", + "looking for paths in the network with length: 10 for node MAPK3_T202 and MAPK3\n", + "i_search = 4\n", + "Looking for paths with length: 0 for node MAPK3_T202 and MAPK3\n", + "i_search = 4\n", + "Looking for paths with length: 1 for node MAPK3_T202 and MAPK3\n", + "i_search = 4\n", + "Looking for paths with length: 2 for node MAPK3_T202 and MAPK3\n", + "i_search = 4\n", + "Looking for paths with length: 3 for node MAPK3_T202 and MAPK3\n", + "i_search = 4\n", + "Looking for paths with length: 4 for node MAPK3_T202 and MAPK3\n", + "looking for paths in the network with length: 0 for node MAPK3_T202 and PTPN11\n", + "looking for paths in the network with length: 1 for node MAPK3_T202 and PTPN11\n", + "looking for paths in the network with length: 2 for node MAPK3_T202 and PTPN11\n", + "looking for paths in the network with length: 3 for node MAPK3_T202 and PTPN11\n", + "looking for paths in the network with length: 4 for node MAPK3_T202 and PTPN11\n", + "looking for paths in the network with length: 5 for node MAPK3_T202 and PTPN11\n", + "looking for paths in the network with length: 6 for node MAPK3_T202 and PTPN11\n", + "looking for paths in the network with length: 7 for node MAPK3_T202 and PTPN11\n", + "looking for paths in the network with length: 8 for node MAPK3_T202 and PTPN11\n", + "looking for paths in the network with length: 9 for node MAPK3_T202 and PTPN11\n", + "looking for paths in the network with length: 10 for node MAPK3_T202 and PTPN11\n", + "i_search = 4\n", + "Looking for paths with length: 0 for node MAPK3_T202 and PTPN11\n", + "i_search = 4\n", + "Looking for paths with length: 1 for node MAPK3_T202 and PTPN11\n", + "i_search = 4\n", + "Looking for paths with length: 2 for node MAPK3_T202 and PTPN11\n", + "i_search = 4\n", + "Looking for paths with length: 3 for node MAPK3_T202 and PTPN11\n", + "i_search = 4\n", + "Looking for paths with length: 4 for node MAPK3_T202 and PTPN11\n", + "looking for paths in the network with length: 0 for node MAPK3_T202 and STAT3\n", + "looking for paths in the network with length: 1 for node MAPK3_T202 and STAT3\n", + "looking for paths in the network with length: 2 for node MAPK3_T202 and STAT3\n", + "looking for paths in the network with length: 3 for node MAPK3_T202 and STAT3\n", + "looking for paths in the network with length: 4 for node MAPK3_T202 and STAT3\n", + "looking for paths in the network with length: 5 for node MAPK3_T202 and STAT3\n", + "looking for paths in the network with length: 6 for node MAPK3_T202 and STAT3\n", + "looking for paths in the network with length: 7 for node MAPK3_T202 and STAT3\n", + "looking for paths in the network with length: 8 for node MAPK3_T202 and STAT3\n", + "looking for paths in the network with length: 9 for node MAPK3_T202 and STAT3\n", + "looking for paths in the network with length: 10 for node MAPK3_T202 and STAT3\n", + "i_search = 4\n", + "Looking for paths with length: 0 for node MAPK3_T202 and STAT3\n", + "i_search = 4\n", + "Looking for paths with length: 1 for node MAPK3_T202 and STAT3\n", + "i_search = 4\n", + "Looking for paths with length: 2 for node MAPK3_T202 and STAT3\n", + "i_search = 4\n", + "Looking for paths with length: 3 for node MAPK3_T202 and STAT3\n", + "i_search = 4\n", + "Looking for paths with length: 4 for node MAPK3_T202 and STAT3\n", + "looking for paths in the network with length: 0 for node MAPK3_T202 and CHEK2\n", + "looking for paths in the network with length: 1 for node MAPK3_T202 and CHEK2\n", + "looking for paths in the network with length: 2 for node MAPK3_T202 and CHEK2\n", + "looking for paths in the network with length: 3 for node MAPK3_T202 and CHEK2\n", + "looking for paths in the network with length: 4 for node MAPK3_T202 and CHEK2\n", + "looking for paths in the network with length: 5 for node MAPK3_T202 and CHEK2\n", + "looking for paths in the network with length: 6 for node MAPK3_T202 and CHEK2\n", + "looking for paths in the network with length: 7 for node MAPK3_T202 and CHEK2\n", + "looking for paths in the network with length: 8 for node MAPK3_T202 and CHEK2\n", + "looking for paths in the network with length: 9 for node MAPK3_T202 and CHEK2\n", + "looking for paths in the network with length: 10 for node MAPK3_T202 and CHEK2\n", + "i_search = 4\n", + "Looking for paths with length: 0 for node MAPK3_T202 and CHEK2\n", + "i_search = 4\n", + "Looking for paths with length: 1 for node MAPK3_T202 and CHEK2\n", + "i_search = 4\n", + "Looking for paths with length: 2 for node MAPK3_T202 and CHEK2\n", + "i_search = 4\n", + "Looking for paths with length: 3 for node MAPK3_T202 and CHEK2\n", + "i_search = 4\n", + "Looking for paths with length: 4 for node MAPK3_T202 and CHEK2\n", + "looking for paths in the network with length: 0 for node MAPK3_T202 and RELA\n", + "looking for paths in the network with length: 1 for node MAPK3_T202 and RELA\n", + "looking for paths in the network with length: 2 for node MAPK3_T202 and RELA\n", + "looking for paths in the network with length: 3 for node MAPK3_T202 and RELA\n", + "looking for paths in the network with length: 4 for node MAPK3_T202 and RELA\n", + "looking for paths in the network with length: 5 for node MAPK3_T202 and RELA\n", + "looking for paths in the network with length: 6 for node MAPK3_T202 and RELA\n", + "looking for paths in the network with length: 7 for node MAPK3_T202 and RELA\n", + "looking for paths in the network with length: 8 for node MAPK3_T202 and RELA\n", + "looking for paths in the network with length: 9 for node MAPK3_T202 and RELA\n", + "looking for paths in the network with length: 10 for node MAPK3_T202 and RELA\n", + "i_search = 4\n", + "Looking for paths with length: 0 for node MAPK3_T202 and RELA\n", + "i_search = 4\n", + "Looking for paths with length: 1 for node MAPK3_T202 and RELA\n", + "i_search = 4\n", + "Looking for paths with length: 2 for node MAPK3_T202 and RELA\n", + "i_search = 4\n", + "Looking for paths with length: 3 for node MAPK3_T202 and RELA\n", + "i_search = 4\n", + "Looking for paths with length: 4 for node MAPK3_T202 and RELA\n", + "looking for paths in the network with length: 0 for node MAPK3_T202 and MARCKS\n", + "looking for paths in the network with length: 1 for node MAPK3_T202 and MARCKS\n", + "looking for paths in the network with length: 2 for node MAPK3_T202 and MARCKS\n", + "looking for paths in the network with length: 3 for node MAPK3_T202 and MARCKS\n", + "looking for paths in the network with length: 4 for node MAPK3_T202 and MARCKS\n", + "looking for paths in the network with length: 5 for node MAPK3_T202 and MARCKS\n", + "looking for paths in the network with length: 6 for node MAPK3_T202 and MARCKS\n", + "looking for paths in the network with length: 7 for node MAPK3_T202 and MARCKS\n", + "looking for paths in the network with length: 8 for node MAPK3_T202 and MARCKS\n", + "looking for paths in the network with length: 9 for node MAPK3_T202 and MARCKS\n", + "looking for paths in the network with length: 10 for node MAPK3_T202 and MARCKS\n", + "i_search = 4\n", + "Looking for paths with length: 0 for node MAPK3_T202 and MARCKS\n", + "i_search = 4\n", + "Looking for paths with length: 1 for node MAPK3_T202 and MARCKS\n", + "i_search = 4\n", + "Looking for paths with length: 2 for node MAPK3_T202 and MARCKS\n", + "i_search = 4\n", + "Looking for paths with length: 3 for node MAPK3_T202 and MARCKS\n", + "i_search = 4\n", + "Looking for paths with length: 4 for node MAPK3_T202 and MARCKS\n", + "looking for paths in the network with length: 0 for node MAPK3_Y204 and PTPN11_Y542\n", + "looking for paths in the network with length: 1 for node MAPK3_Y204 and PTPN11_Y542\n", + "looking for paths in the network with length: 2 for node MAPK3_Y204 and PTPN11_Y542\n", + "looking for paths in the network with length: 3 for node MAPK3_Y204 and PTPN11_Y542\n", + "looking for paths in the network with length: 4 for node MAPK3_Y204 and PTPN11_Y542\n", + "looking for paths in the network with length: 5 for node MAPK3_Y204 and PTPN11_Y542\n", + "looking for paths in the network with length: 6 for node MAPK3_Y204 and PTPN11_Y542\n", + "looking for paths in the network with length: 7 for node MAPK3_Y204 and PTPN11_Y542\n", + "looking for paths in the network with length: 8 for node MAPK3_Y204 and PTPN11_Y542\n", + "looking for paths in the network with length: 9 for node MAPK3_Y204 and PTPN11_Y542\n", + "looking for paths in the network with length: 10 for node MAPK3_Y204 and PTPN11_Y542\n", + "i_search = 4\n", + "Looking for paths with length: 0 for node MAPK3_Y204 and PTPN11_Y542\n", + "i_search = 4\n", + "Looking for paths with length: 1 for node MAPK3_Y204 and PTPN11_Y542\n", + "i_search = 4\n", + "Looking for paths with length: 2 for node MAPK3_Y204 and PTPN11_Y542\n", + "i_search = 4\n", + "Looking for paths with length: 3 for node MAPK3_Y204 and PTPN11_Y542\n", + "i_search = 4\n", + "Looking for paths with length: 4 for node MAPK3_Y204 and PTPN11_Y542\n", + "looking for paths in the network with length: 0 for node MAPK3_Y204 and STAT3_Y705\n", + "looking for paths in the network with length: 1 for node MAPK3_Y204 and STAT3_Y705\n", + "looking for paths in the network with length: 2 for node MAPK3_Y204 and STAT3_Y705\n", + "looking for paths in the network with length: 3 for node MAPK3_Y204 and STAT3_Y705\n", + "looking for paths in the network with length: 4 for node MAPK3_Y204 and STAT3_Y705\n", + "looking for paths in the network with length: 5 for node MAPK3_Y204 and STAT3_Y705\n", + "looking for paths in the network with length: 6 for node MAPK3_Y204 and STAT3_Y705\n", + "Found a path!\n", + "[['MAPK3_Y204', 'MAPK3', 'GSK3B_T43', 'GSK3B', 'SRC_S493', 'SRC', 'STAT3_Y705'], ['MAPK3_Y204', 'MAPK3', 'GSK3B_T43', 'GSK3B', 'SRC_S51', 'SRC', 'STAT3_Y705'], ['MAPK3_Y204', 'MAPK3', 'GSK3B_T43', 'GSK3B', 'SRC_S43', 'SRC', 'STAT3_Y705'], ['MAPK3_Y204', 'MAPK3', 'GSK3B_T43', 'GSK3B', 'SRC_Y419', 'SRC', 'STAT3_Y705']]\n", + "looking for paths in the network with length: 0 for node MAPK3_Y204 and CHEK2_T68\n", + "looking for paths in the network with length: 1 for node MAPK3_Y204 and CHEK2_T68\n", + "looking for paths in the network with length: 2 for node MAPK3_Y204 and CHEK2_T68\n", + "looking for paths in the network with length: 3 for node MAPK3_Y204 and CHEK2_T68\n", + "looking for paths in the network with length: 4 for node MAPK3_Y204 and CHEK2_T68\n", + "looking for paths in the network with length: 5 for node MAPK3_Y204 and CHEK2_T68\n", + "looking for paths in the network with length: 6 for node MAPK3_Y204 and CHEK2_T68\n", + "looking for paths in the network with length: 7 for node MAPK3_Y204 and CHEK2_T68\n", + "looking for paths in the network with length: 8 for node MAPK3_Y204 and CHEK2_T68\n", + "looking for paths in the network with length: 9 for node MAPK3_Y204 and CHEK2_T68\n", + "looking for paths in the network with length: 10 for node MAPK3_Y204 and CHEK2_T68\n", + "i_search = 4\n", + "Looking for paths with length: 0 for node MAPK3_Y204 and CHEK2_T68\n", + "i_search = 4\n", + "Looking for paths with length: 1 for node MAPK3_Y204 and CHEK2_T68\n", + "i_search = 4\n", + "Looking for paths with length: 2 for node MAPK3_Y204 and CHEK2_T68\n", + "i_search = 4\n", + "Looking for paths with length: 3 for node MAPK3_Y204 and CHEK2_T68\n", + "i_search = 4\n", + "Looking for paths with length: 4 for node MAPK3_Y204 and CHEK2_T68\n", + "looking for paths in the network with length: 0 for node MAPK3_Y204 and RELA_S536\n", + "looking for paths in the network with length: 1 for node MAPK3_Y204 and RELA_S536\n", + "looking for paths in the network with length: 2 for node MAPK3_Y204 and RELA_S536\n", + "looking for paths in the network with length: 3 for node MAPK3_Y204 and RELA_S536\n", + "looking for paths in the network with length: 4 for node MAPK3_Y204 and RELA_S536\n", + "looking for paths in the network with length: 5 for node MAPK3_Y204 and RELA_S536\n", + "looking for paths in the network with length: 6 for node MAPK3_Y204 and RELA_S536\n", + "Found a path!\n", + "[['MAPK3_Y204', 'MAPK3', 'GSK3B_T43', 'GSK3B', 'TBK1_S172', 'TBK1', 'RELA_S536']]\n", + "looking for paths in the network with length: 0 for node MAPK3_Y204 and MARCKS_S170\n", + "looking for paths in the network with length: 1 for node MAPK3_Y204 and MARCKS_S170\n", + "looking for paths in the network with length: 2 for node MAPK3_Y204 and MARCKS_S170\n", + "looking for paths in the network with length: 3 for node MAPK3_Y204 and MARCKS_S170\n", + "looking for paths in the network with length: 4 for node MAPK3_Y204 and MARCKS_S170\n", + "looking for paths in the network with length: 5 for node MAPK3_Y204 and MARCKS_S170\n", + "looking for paths in the network with length: 6 for node MAPK3_Y204 and MARCKS_S170\n", + "looking for paths in the network with length: 7 for node MAPK3_Y204 and MARCKS_S170\n", + "looking for paths in the network with length: 8 for node MAPK3_Y204 and MARCKS_S170\n", + "looking for paths in the network with length: 9 for node MAPK3_Y204 and MARCKS_S170\n", + "looking for paths in the network with length: 10 for node MAPK3_Y204 and MARCKS_S170\n", + "i_search = 4\n", + "Looking for paths with length: 0 for node MAPK3_Y204 and MARCKS_S170\n", + "i_search = 4\n", + "Looking for paths with length: 1 for node MAPK3_Y204 and MARCKS_S170\n", + "i_search = 4\n", + "Looking for paths with length: 2 for node MAPK3_Y204 and MARCKS_S170\n", + "i_search = 4\n", + "Looking for paths with length: 3 for node MAPK3_Y204 and MARCKS_S170\n", + "i_search = 4\n", + "Looking for paths with length: 4 for node MAPK3_Y204 and MARCKS_S170\n", + "looking for paths in the network with length: 0 for node MAPK3_Y204 and SMAD3\n", + "looking for paths in the network with length: 1 for node MAPK3_Y204 and SMAD3\n", + "looking for paths in the network with length: 2 for node MAPK3_Y204 and SMAD3\n", + "looking for paths in the network with length: 3 for node MAPK3_Y204 and SMAD3\n", + "looking for paths in the network with length: 4 for node MAPK3_Y204 and SMAD3\n", + "looking for paths in the network with length: 5 for node MAPK3_Y204 and SMAD3\n", + "looking for paths in the network with length: 6 for node MAPK3_Y204 and SMAD3\n", + "looking for paths in the network with length: 7 for node MAPK3_Y204 and SMAD3\n", + "looking for paths in the network with length: 8 for node MAPK3_Y204 and SMAD3\n", + "looking for paths in the network with length: 9 for node MAPK3_Y204 and SMAD3\n", + "looking for paths in the network with length: 10 for node MAPK3_Y204 and SMAD3\n", + "i_search = 4\n", + "Looking for paths with length: 0 for node MAPK3_Y204 and SMAD3\n", + "i_search = 4\n", + "Looking for paths with length: 1 for node MAPK3_Y204 and SMAD3\n", + "i_search = 4\n", + "Looking for paths with length: 2 for node MAPK3_Y204 and SMAD3\n", + "i_search = 4\n", + "Looking for paths with length: 3 for node MAPK3_Y204 and SMAD3\n", + "i_search = 4\n", + "Looking for paths with length: 4 for node MAPK3_Y204 and SMAD3\n", + "looking for paths in the network with length: 0 for node MAPK3_Y204 and TP53\n", + "looking for paths in the network with length: 1 for node MAPK3_Y204 and TP53\n", + "looking for paths in the network with length: 2 for node MAPK3_Y204 and TP53\n", + "looking for paths in the network with length: 3 for node MAPK3_Y204 and TP53\n", + "looking for paths in the network with length: 4 for node MAPK3_Y204 and TP53\n", + "looking for paths in the network with length: 5 for node MAPK3_Y204 and TP53\n", + "looking for paths in the network with length: 6 for node MAPK3_Y204 and TP53\n", + "looking for paths in the network with length: 7 for node MAPK3_Y204 and TP53\n", + "looking for paths in the network with length: 8 for node MAPK3_Y204 and TP53\n", + "looking for paths in the network with length: 9 for node MAPK3_Y204 and TP53\n", + "looking for paths in the network with length: 10 for node MAPK3_Y204 and TP53\n", + "i_search = 4\n", + "Looking for paths with length: 0 for node MAPK3_Y204 and TP53\n", + "i_search = 4\n", + "Looking for paths with length: 1 for node MAPK3_Y204 and TP53\n", + "i_search = 4\n", + "Looking for paths with length: 2 for node MAPK3_Y204 and TP53\n", + "i_search = 4\n", + "Looking for paths with length: 3 for node MAPK3_Y204 and TP53\n", + "i_search = 4\n", + "Looking for paths with length: 4 for node MAPK3_Y204 and TP53\n", + "looking for paths in the network with length: 0 for node MAPK3_Y204 and AKT1S1\n", + "looking for paths in the network with length: 1 for node MAPK3_Y204 and AKT1S1\n", + "looking for paths in the network with length: 2 for node MAPK3_Y204 and AKT1S1\n", + "looking for paths in the network with length: 3 for node MAPK3_Y204 and AKT1S1\n", + "looking for paths in the network with length: 4 for node MAPK3_Y204 and AKT1S1\n", + "looking for paths in the network with length: 5 for node MAPK3_Y204 and AKT1S1\n", + "looking for paths in the network with length: 6 for node MAPK3_Y204 and AKT1S1\n", + "looking for paths in the network with length: 7 for node MAPK3_Y204 and AKT1S1\n", + "looking for paths in the network with length: 8 for node MAPK3_Y204 and AKT1S1\n", + "looking for paths in the network with length: 9 for node MAPK3_Y204 and AKT1S1\n", + "looking for paths in the network with length: 10 for node MAPK3_Y204 and AKT1S1\n", + "i_search = 4\n", + "Looking for paths with length: 0 for node MAPK3_Y204 and AKT1S1\n", + "i_search = 4\n", + "Looking for paths with length: 1 for node MAPK3_Y204 and AKT1S1\n", + "i_search = 4\n", + "Looking for paths with length: 2 for node MAPK3_Y204 and AKT1S1\n", + "i_search = 4\n", + "Looking for paths with length: 3 for node MAPK3_Y204 and AKT1S1\n", + "i_search = 4\n", + "Looking for paths with length: 4 for node MAPK3_Y204 and AKT1S1\n", + "looking for paths in the network with length: 0 for node MAPK3_Y204 and GSK3B\n", + "looking for paths in the network with length: 1 for node MAPK3_Y204 and GSK3B\n", + "looking for paths in the network with length: 2 for node MAPK3_Y204 and GSK3B\n", + "looking for paths in the network with length: 3 for node MAPK3_Y204 and GSK3B\n", + "looking for paths in the network with length: 4 for node MAPK3_Y204 and GSK3B\n", + "looking for paths in the network with length: 5 for node MAPK3_Y204 and GSK3B\n", + "looking for paths in the network with length: 6 for node MAPK3_Y204 and GSK3B\n", + "looking for paths in the network with length: 7 for node MAPK3_Y204 and GSK3B\n", + "looking for paths in the network with length: 8 for node MAPK3_Y204 and GSK3B\n", + "looking for paths in the network with length: 9 for node MAPK3_Y204 and GSK3B\n", + "looking for paths in the network with length: 10 for node MAPK3_Y204 and GSK3B\n", + "i_search = 4\n", + "Looking for paths with length: 0 for node MAPK3_Y204 and GSK3B\n", + "i_search = 4\n", + "Looking for paths with length: 1 for node MAPK3_Y204 and GSK3B\n", + "i_search = 4\n", + "Looking for paths with length: 2 for node MAPK3_Y204 and GSK3B\n", + "i_search = 4\n", + "Looking for paths with length: 3 for node MAPK3_Y204 and GSK3B\n", + "i_search = 4\n", + "Looking for paths with length: 4 for node MAPK3_Y204 and GSK3B\n", + "looking for paths in the network with length: 0 for node MAPK3_Y204 and AKT1\n", + "looking for paths in the network with length: 1 for node MAPK3_Y204 and AKT1\n", + "looking for paths in the network with length: 2 for node MAPK3_Y204 and AKT1\n", + "looking for paths in the network with length: 3 for node MAPK3_Y204 and AKT1\n", + "looking for paths in the network with length: 4 for node MAPK3_Y204 and AKT1\n", + "looking for paths in the network with length: 5 for node MAPK3_Y204 and AKT1\n", + "looking for paths in the network with length: 6 for node MAPK3_Y204 and AKT1\n", + "looking for paths in the network with length: 7 for node MAPK3_Y204 and AKT1\n", + "looking for paths in the network with length: 8 for node MAPK3_Y204 and AKT1\n", + "looking for paths in the network with length: 9 for node MAPK3_Y204 and AKT1\n", + "looking for paths in the network with length: 10 for node MAPK3_Y204 and AKT1\n", + "i_search = 4\n", + "Looking for paths with length: 0 for node MAPK3_Y204 and AKT1\n", + "i_search = 4\n", + "Looking for paths with length: 1 for node MAPK3_Y204 and AKT1\n", + "i_search = 4\n", + "Looking for paths with length: 2 for node MAPK3_Y204 and AKT1\n", + "i_search = 4\n", + "Looking for paths with length: 3 for node MAPK3_Y204 and AKT1\n", + "i_search = 4\n", + "Looking for paths with length: 4 for node MAPK3_Y204 and AKT1\n", + "looking for paths in the network with length: 0 for node MAPK3_Y204 and HSPB1\n", + "looking for paths in the network with length: 1 for node MAPK3_Y204 and HSPB1\n", + "looking for paths in the network with length: 2 for node MAPK3_Y204 and HSPB1\n", + "looking for paths in the network with length: 3 for node MAPK3_Y204 and HSPB1\n", + "looking for paths in the network with length: 4 for node MAPK3_Y204 and HSPB1\n", + "looking for paths in the network with length: 5 for node MAPK3_Y204 and HSPB1\n", + "looking for paths in the network with length: 6 for node MAPK3_Y204 and HSPB1\n", + "looking for paths in the network with length: 7 for node MAPK3_Y204 and HSPB1\n", + "looking for paths in the network with length: 8 for node MAPK3_Y204 and HSPB1\n", + "looking for paths in the network with length: 9 for node MAPK3_Y204 and HSPB1\n", + "looking for paths in the network with length: 10 for node MAPK3_Y204 and HSPB1\n", + "i_search = 4\n", + "Looking for paths with length: 0 for node MAPK3_Y204 and HSPB1\n", + "i_search = 4\n", + "Looking for paths with length: 1 for node MAPK3_Y204 and HSPB1\n", + "i_search = 4\n", + "Looking for paths with length: 2 for node MAPK3_Y204 and HSPB1\n", + "i_search = 4\n", + "Looking for paths with length: 3 for node MAPK3_Y204 and HSPB1\n", + "i_search = 4\n", + "Looking for paths with length: 4 for node MAPK3_Y204 and HSPB1\n", + "looking for paths in the network with length: 0 for node MAPK3_Y204 and MAPK14\n", + "looking for paths in the network with length: 1 for node MAPK3_Y204 and MAPK14\n", + "looking for paths in the network with length: 2 for node MAPK3_Y204 and MAPK14\n", + "looking for paths in the network with length: 3 for node MAPK3_Y204 and MAPK14\n", + "looking for paths in the network with length: 4 for node MAPK3_Y204 and MAPK14\n", + "looking for paths in the network with length: 5 for node MAPK3_Y204 and MAPK14\n", + "looking for paths in the network with length: 6 for node MAPK3_Y204 and MAPK14\n", + "looking for paths in the network with length: 7 for node MAPK3_Y204 and MAPK14\n", + "looking for paths in the network with length: 8 for node MAPK3_Y204 and MAPK14\n", + "looking for paths in the network with length: 9 for node MAPK3_Y204 and MAPK14\n", + "looking for paths in the network with length: 10 for node MAPK3_Y204 and MAPK14\n", + "i_search = 4\n", + "Looking for paths with length: 0 for node MAPK3_Y204 and MAPK14\n", + "i_search = 4\n", + "Looking for paths with length: 1 for node MAPK3_Y204 and MAPK14\n", + "i_search = 4\n", + "Looking for paths with length: 2 for node MAPK3_Y204 and MAPK14\n", + "i_search = 4\n", + "Looking for paths with length: 3 for node MAPK3_Y204 and MAPK14\n", + "i_search = 4\n", + "Looking for paths with length: 4 for node MAPK3_Y204 and MAPK14\n", + "looking for paths in the network with length: 0 for node MAPK3_Y204 and MAP2K1\n", + "looking for paths in the network with length: 1 for node MAPK3_Y204 and MAP2K1\n", + "looking for paths in the network with length: 2 for node MAPK3_Y204 and MAP2K1\n", + "looking for paths in the network with length: 3 for node MAPK3_Y204 and MAP2K1\n", + "looking for paths in the network with length: 4 for node MAPK3_Y204 and MAP2K1\n", + "looking for paths in the network with length: 5 for node MAPK3_Y204 and MAP2K1\n", + "looking for paths in the network with length: 6 for node MAPK3_Y204 and MAP2K1\n", + "looking for paths in the network with length: 7 for node MAPK3_Y204 and MAP2K1\n", + "looking for paths in the network with length: 8 for node MAPK3_Y204 and MAP2K1\n", + "looking for paths in the network with length: 9 for node MAPK3_Y204 and MAP2K1\n", + "looking for paths in the network with length: 10 for node MAPK3_Y204 and MAP2K1\n", + "i_search = 4\n", + "Looking for paths with length: 0 for node MAPK3_Y204 and MAP2K1\n", + "i_search = 4\n", + "Looking for paths with length: 1 for node MAPK3_Y204 and MAP2K1\n", + "i_search = 4\n", + "Looking for paths with length: 2 for node MAPK3_Y204 and MAP2K1\n", + "i_search = 4\n", + "Looking for paths with length: 3 for node MAPK3_Y204 and MAP2K1\n", + "i_search = 4\n", + "Looking for paths with length: 4 for node MAPK3_Y204 and MAP2K1\n", + "looking for paths in the network with length: 0 for node MAPK3_Y204 and RPS6KA1\n", + "looking for paths in the network with length: 1 for node MAPK3_Y204 and RPS6KA1\n", + "looking for paths in the network with length: 2 for node MAPK3_Y204 and RPS6KA1\n", + "looking for paths in the network with length: 3 for node MAPK3_Y204 and RPS6KA1\n", + "looking for paths in the network with length: 4 for node MAPK3_Y204 and RPS6KA1\n", + "looking for paths in the network with length: 5 for node MAPK3_Y204 and RPS6KA1\n", + "looking for paths in the network with length: 6 for node MAPK3_Y204 and RPS6KA1\n", + "looking for paths in the network with length: 7 for node MAPK3_Y204 and RPS6KA1\n", + "looking for paths in the network with length: 8 for node MAPK3_Y204 and RPS6KA1\n", + "looking for paths in the network with length: 9 for node MAPK3_Y204 and RPS6KA1\n", + "looking for paths in the network with length: 10 for node MAPK3_Y204 and RPS6KA1\n", + "i_search = 4\n", + "Looking for paths with length: 0 for node MAPK3_Y204 and RPS6KA1\n", + "i_search = 4\n", + "Looking for paths with length: 1 for node MAPK3_Y204 and RPS6KA1\n", + "i_search = 4\n", + "Looking for paths with length: 2 for node MAPK3_Y204 and RPS6KA1\n", + "i_search = 4\n", + "Looking for paths with length: 3 for node MAPK3_Y204 and RPS6KA1\n", + "i_search = 4\n", + "Looking for paths with length: 4 for node MAPK3_Y204 and RPS6KA1\n", + "looking for paths in the network with length: 0 for node MAPK3_Y204 and CREB1\n", + "looking for paths in the network with length: 1 for node MAPK3_Y204 and CREB1\n", + "looking for paths in the network with length: 2 for node MAPK3_Y204 and CREB1\n", + "looking for paths in the network with length: 3 for node MAPK3_Y204 and CREB1\n", + "looking for paths in the network with length: 4 for node MAPK3_Y204 and CREB1\n", + "looking for paths in the network with length: 5 for node MAPK3_Y204 and CREB1\n", + "looking for paths in the network with length: 6 for node MAPK3_Y204 and CREB1\n", + "looking for paths in the network with length: 7 for node MAPK3_Y204 and CREB1\n", + "looking for paths in the network with length: 8 for node MAPK3_Y204 and CREB1\n", + "looking for paths in the network with length: 9 for node MAPK3_Y204 and CREB1\n", + "looking for paths in the network with length: 10 for node MAPK3_Y204 and CREB1\n", + "i_search = 4\n", + "Looking for paths with length: 0 for node MAPK3_Y204 and CREB1\n", + "i_search = 4\n", + "Looking for paths with length: 1 for node MAPK3_Y204 and CREB1\n", + "i_search = 4\n", + "Looking for paths with length: 2 for node MAPK3_Y204 and CREB1\n", + "i_search = 4\n", + "Looking for paths with length: 3 for node MAPK3_Y204 and CREB1\n", + "i_search = 4\n", + "Looking for paths with length: 4 for node MAPK3_Y204 and CREB1\n", + "looking for paths in the network with length: 0 for node MAPK3_Y204 and NFKBIA\n", + "looking for paths in the network with length: 1 for node MAPK3_Y204 and NFKBIA\n", + "looking for paths in the network with length: 2 for node MAPK3_Y204 and NFKBIA\n", + "looking for paths in the network with length: 3 for node MAPK3_Y204 and NFKBIA\n", + "looking for paths in the network with length: 4 for node MAPK3_Y204 and NFKBIA\n", + "looking for paths in the network with length: 5 for node MAPK3_Y204 and NFKBIA\n", + "looking for paths in the network with length: 6 for node MAPK3_Y204 and NFKBIA\n", + "looking for paths in the network with length: 7 for node MAPK3_Y204 and NFKBIA\n", + "looking for paths in the network with length: 8 for node MAPK3_Y204 and NFKBIA\n", + "looking for paths in the network with length: 9 for node MAPK3_Y204 and NFKBIA\n", + "looking for paths in the network with length: 10 for node MAPK3_Y204 and NFKBIA\n", + "i_search = 4\n", + "Looking for paths with length: 0 for node MAPK3_Y204 and NFKBIA\n", + "i_search = 4\n", + "Looking for paths with length: 1 for node MAPK3_Y204 and NFKBIA\n", + "i_search = 4\n", + "Looking for paths with length: 2 for node MAPK3_Y204 and NFKBIA\n", + "i_search = 4\n", + "Looking for paths with length: 3 for node MAPK3_Y204 and NFKBIA\n", + "i_search = 4\n", + "Looking for paths with length: 4 for node MAPK3_Y204 and NFKBIA\n", + "looking for paths in the network with length: 0 for node MAPK3_Y204 and MTOR\n", + "looking for paths in the network with length: 1 for node MAPK3_Y204 and MTOR\n", + "looking for paths in the network with length: 2 for node MAPK3_Y204 and MTOR\n", + "looking for paths in the network with length: 3 for node MAPK3_Y204 and MTOR\n", + "looking for paths in the network with length: 4 for node MAPK3_Y204 and MTOR\n", + "looking for paths in the network with length: 5 for node MAPK3_Y204 and MTOR\n", + "looking for paths in the network with length: 6 for node MAPK3_Y204 and MTOR\n", + "looking for paths in the network with length: 7 for node MAPK3_Y204 and MTOR\n", + "looking for paths in the network with length: 8 for node MAPK3_Y204 and MTOR\n", + "looking for paths in the network with length: 9 for node MAPK3_Y204 and MTOR\n", + "looking for paths in the network with length: 10 for node MAPK3_Y204 and MTOR\n", + "i_search = 4\n", + "Looking for paths with length: 0 for node MAPK3_Y204 and MTOR\n", + "i_search = 4\n", + "Looking for paths with length: 1 for node MAPK3_Y204 and MTOR\n", + "i_search = 4\n", + "Looking for paths with length: 2 for node MAPK3_Y204 and MTOR\n", + "i_search = 4\n", + "Looking for paths with length: 3 for node MAPK3_Y204 and MTOR\n", + "i_search = 4\n", + "Looking for paths with length: 4 for node MAPK3_Y204 and MTOR\n", + "looking for paths in the network with length: 0 for node MAPK3_Y204 and JUN\n", + "looking for paths in the network with length: 1 for node MAPK3_Y204 and JUN\n", + "looking for paths in the network with length: 2 for node MAPK3_Y204 and JUN\n", + "looking for paths in the network with length: 3 for node MAPK3_Y204 and JUN\n", + "looking for paths in the network with length: 4 for node MAPK3_Y204 and JUN\n", + "looking for paths in the network with length: 5 for node MAPK3_Y204 and JUN\n", + "looking for paths in the network with length: 6 for node MAPK3_Y204 and JUN\n", + "looking for paths in the network with length: 7 for node MAPK3_Y204 and JUN\n", + "looking for paths in the network with length: 8 for node MAPK3_Y204 and JUN\n", + "looking for paths in the network with length: 9 for node MAPK3_Y204 and JUN\n", + "looking for paths in the network with length: 10 for node MAPK3_Y204 and JUN\n", + "i_search = 4\n", + "Looking for paths with length: 0 for node MAPK3_Y204 and JUN\n", + "i_search = 4\n", + "Looking for paths with length: 1 for node MAPK3_Y204 and JUN\n", + "i_search = 4\n", + "Looking for paths with length: 2 for node MAPK3_Y204 and JUN\n", + "i_search = 4\n", + "Looking for paths with length: 3 for node MAPK3_Y204 and JUN\n", + "i_search = 4\n", + "Looking for paths with length: 4 for node MAPK3_Y204 and JUN\n", + "looking for paths in the network with length: 0 for node MAPK3_Y204 and EGFR\n", + "looking for paths in the network with length: 1 for node MAPK3_Y204 and EGFR\n", + "looking for paths in the network with length: 2 for node MAPK3_Y204 and EGFR\n", + "looking for paths in the network with length: 3 for node MAPK3_Y204 and EGFR\n", + "looking for paths in the network with length: 4 for node MAPK3_Y204 and EGFR\n", + "looking for paths in the network with length: 5 for node MAPK3_Y204 and EGFR\n", + "looking for paths in the network with length: 6 for node MAPK3_Y204 and EGFR\n", + "looking for paths in the network with length: 7 for node MAPK3_Y204 and EGFR\n", + "looking for paths in the network with length: 8 for node MAPK3_Y204 and EGFR\n", + "looking for paths in the network with length: 9 for node MAPK3_Y204 and EGFR\n", + "looking for paths in the network with length: 10 for node MAPK3_Y204 and EGFR\n", + "i_search = 4\n", + "Looking for paths with length: 0 for node MAPK3_Y204 and EGFR\n", + "i_search = 4\n", + "Looking for paths with length: 1 for node MAPK3_Y204 and EGFR\n", + "i_search = 4\n", + "Looking for paths with length: 2 for node MAPK3_Y204 and EGFR\n", + "i_search = 4\n", + "Looking for paths with length: 3 for node MAPK3_Y204 and EGFR\n", + "i_search = 4\n", + "Looking for paths with length: 4 for node MAPK3_Y204 and EGFR\n", + "looking for paths in the network with length: 0 for node MAPK3_Y204 and MAPK3\n", + "looking for paths in the network with length: 1 for node MAPK3_Y204 and MAPK3\n", + "looking for paths in the network with length: 2 for node MAPK3_Y204 and MAPK3\n", + "looking for paths in the network with length: 3 for node MAPK3_Y204 and MAPK3\n", + "looking for paths in the network with length: 4 for node MAPK3_Y204 and MAPK3\n", + "looking for paths in the network with length: 5 for node MAPK3_Y204 and MAPK3\n", + "looking for paths in the network with length: 6 for node MAPK3_Y204 and MAPK3\n", + "looking for paths in the network with length: 7 for node MAPK3_Y204 and MAPK3\n", + "looking for paths in the network with length: 8 for node MAPK3_Y204 and MAPK3\n", + "looking for paths in the network with length: 9 for node MAPK3_Y204 and MAPK3\n", + "looking for paths in the network with length: 10 for node MAPK3_Y204 and MAPK3\n", + "i_search = 4\n", + "Looking for paths with length: 0 for node MAPK3_Y204 and MAPK3\n", + "i_search = 4\n", + "Looking for paths with length: 1 for node MAPK3_Y204 and MAPK3\n", + "i_search = 4\n", + "Looking for paths with length: 2 for node MAPK3_Y204 and MAPK3\n", + "i_search = 4\n", + "Looking for paths with length: 3 for node MAPK3_Y204 and MAPK3\n", + "i_search = 4\n", + "Looking for paths with length: 4 for node MAPK3_Y204 and MAPK3\n", + "looking for paths in the network with length: 0 for node MAPK3_Y204 and PTPN11\n", + "looking for paths in the network with length: 1 for node MAPK3_Y204 and PTPN11\n", + "looking for paths in the network with length: 2 for node MAPK3_Y204 and PTPN11\n", + "looking for paths in the network with length: 3 for node MAPK3_Y204 and PTPN11\n", + "looking for paths in the network with length: 4 for node MAPK3_Y204 and PTPN11\n", + "looking for paths in the network with length: 5 for node MAPK3_Y204 and PTPN11\n", + "looking for paths in the network with length: 6 for node MAPK3_Y204 and PTPN11\n", + "looking for paths in the network with length: 7 for node MAPK3_Y204 and PTPN11\n", + "looking for paths in the network with length: 8 for node MAPK3_Y204 and PTPN11\n", + "looking for paths in the network with length: 9 for node MAPK3_Y204 and PTPN11\n", + "looking for paths in the network with length: 10 for node MAPK3_Y204 and PTPN11\n", + "i_search = 4\n", + "Looking for paths with length: 0 for node MAPK3_Y204 and PTPN11\n", + "i_search = 4\n", + "Looking for paths with length: 1 for node MAPK3_Y204 and PTPN11\n", + "i_search = 4\n", + "Looking for paths with length: 2 for node MAPK3_Y204 and PTPN11\n", + "i_search = 4\n", + "Looking for paths with length: 3 for node MAPK3_Y204 and PTPN11\n", + "i_search = 4\n", + "Looking for paths with length: 4 for node MAPK3_Y204 and PTPN11\n", + "looking for paths in the network with length: 0 for node MAPK3_Y204 and STAT3\n", + "looking for paths in the network with length: 1 for node MAPK3_Y204 and STAT3\n", + "looking for paths in the network with length: 2 for node MAPK3_Y204 and STAT3\n", + "looking for paths in the network with length: 3 for node MAPK3_Y204 and STAT3\n", + "looking for paths in the network with length: 4 for node MAPK3_Y204 and STAT3\n", + "looking for paths in the network with length: 5 for node MAPK3_Y204 and STAT3\n", + "looking for paths in the network with length: 6 for node MAPK3_Y204 and STAT3\n", + "looking for paths in the network with length: 7 for node MAPK3_Y204 and STAT3\n", + "looking for paths in the network with length: 8 for node MAPK3_Y204 and STAT3\n", + "looking for paths in the network with length: 9 for node MAPK3_Y204 and STAT3\n", + "looking for paths in the network with length: 10 for node MAPK3_Y204 and STAT3\n", + "i_search = 4\n", + "Looking for paths with length: 0 for node MAPK3_Y204 and STAT3\n", + "i_search = 4\n", + "Looking for paths with length: 1 for node MAPK3_Y204 and STAT3\n", + "i_search = 4\n", + "Looking for paths with length: 2 for node MAPK3_Y204 and STAT3\n", + "i_search = 4\n", + "Looking for paths with length: 3 for node MAPK3_Y204 and STAT3\n", + "i_search = 4\n", + "Looking for paths with length: 4 for node MAPK3_Y204 and STAT3\n", + "looking for paths in the network with length: 0 for node MAPK3_Y204 and CHEK2\n", + "looking for paths in the network with length: 1 for node MAPK3_Y204 and CHEK2\n", + "looking for paths in the network with length: 2 for node MAPK3_Y204 and CHEK2\n", + "looking for paths in the network with length: 3 for node MAPK3_Y204 and CHEK2\n", + "looking for paths in the network with length: 4 for node MAPK3_Y204 and CHEK2\n", + "looking for paths in the network with length: 5 for node MAPK3_Y204 and CHEK2\n", + "looking for paths in the network with length: 6 for node MAPK3_Y204 and CHEK2\n", + "looking for paths in the network with length: 7 for node MAPK3_Y204 and CHEK2\n", + "looking for paths in the network with length: 8 for node MAPK3_Y204 and CHEK2\n", + "looking for paths in the network with length: 9 for node MAPK3_Y204 and CHEK2\n", + "looking for paths in the network with length: 10 for node MAPK3_Y204 and CHEK2\n", + "i_search = 4\n", + "Looking for paths with length: 0 for node MAPK3_Y204 and CHEK2\n", + "i_search = 4\n", + "Looking for paths with length: 1 for node MAPK3_Y204 and CHEK2\n", + "i_search = 4\n", + "Looking for paths with length: 2 for node MAPK3_Y204 and CHEK2\n", + "i_search = 4\n", + "Looking for paths with length: 3 for node MAPK3_Y204 and CHEK2\n", + "i_search = 4\n", + "Looking for paths with length: 4 for node MAPK3_Y204 and CHEK2\n", + "looking for paths in the network with length: 0 for node MAPK3_Y204 and RELA\n", + "looking for paths in the network with length: 1 for node MAPK3_Y204 and RELA\n", + "looking for paths in the network with length: 2 for node MAPK3_Y204 and RELA\n", + "looking for paths in the network with length: 3 for node MAPK3_Y204 and RELA\n", + "looking for paths in the network with length: 4 for node MAPK3_Y204 and RELA\n", + "looking for paths in the network with length: 5 for node MAPK3_Y204 and RELA\n", + "looking for paths in the network with length: 6 for node MAPK3_Y204 and RELA\n", + "looking for paths in the network with length: 7 for node MAPK3_Y204 and RELA\n", + "looking for paths in the network with length: 8 for node MAPK3_Y204 and RELA\n", + "looking for paths in the network with length: 9 for node MAPK3_Y204 and RELA\n", + "looking for paths in the network with length: 10 for node MAPK3_Y204 and RELA\n", + "i_search = 4\n", + "Looking for paths with length: 0 for node MAPK3_Y204 and RELA\n", + "i_search = 4\n", + "Looking for paths with length: 1 for node MAPK3_Y204 and RELA\n", + "i_search = 4\n", + "Looking for paths with length: 2 for node MAPK3_Y204 and RELA\n", + "i_search = 4\n", + "Looking for paths with length: 3 for node MAPK3_Y204 and RELA\n", + "i_search = 4\n", + "Looking for paths with length: 4 for node MAPK3_Y204 and RELA\n", + "looking for paths in the network with length: 0 for node MAPK3_Y204 and MARCKS\n", + "looking for paths in the network with length: 1 for node MAPK3_Y204 and MARCKS\n", + "looking for paths in the network with length: 2 for node MAPK3_Y204 and MARCKS\n", + "looking for paths in the network with length: 3 for node MAPK3_Y204 and MARCKS\n", + "looking for paths in the network with length: 4 for node MAPK3_Y204 and MARCKS\n", + "looking for paths in the network with length: 5 for node MAPK3_Y204 and MARCKS\n", + "looking for paths in the network with length: 6 for node MAPK3_Y204 and MARCKS\n", + "looking for paths in the network with length: 7 for node MAPK3_Y204 and MARCKS\n", + "looking for paths in the network with length: 8 for node MAPK3_Y204 and MARCKS\n", + "looking for paths in the network with length: 9 for node MAPK3_Y204 and MARCKS\n", + "looking for paths in the network with length: 10 for node MAPK3_Y204 and MARCKS\n", + "i_search = 4\n", + "Looking for paths with length: 0 for node MAPK3_Y204 and MARCKS\n", + "i_search = 4\n", + "Looking for paths with length: 1 for node MAPK3_Y204 and MARCKS\n", + "i_search = 4\n", + "Looking for paths with length: 2 for node MAPK3_Y204 and MARCKS\n", + "i_search = 4\n", + "Looking for paths with length: 3 for node MAPK3_Y204 and MARCKS\n", + "i_search = 4\n", + "Looking for paths with length: 4 for node MAPK3_Y204 and MARCKS\n", + "looking for paths in the network with length: 0 for node PTPN11_Y542 and STAT3_Y705\n", + "looking for paths in the network with length: 1 for node PTPN11_Y542 and STAT3_Y705\n", + "looking for paths in the network with length: 2 for node PTPN11_Y542 and STAT3_Y705\n", + "looking for paths in the network with length: 3 for node PTPN11_Y542 and STAT3_Y705\n", + "looking for paths in the network with length: 4 for node PTPN11_Y542 and STAT3_Y705\n", + "looking for paths in the network with length: 5 for node PTPN11_Y542 and STAT3_Y705\n", + "looking for paths in the network with length: 6 for node PTPN11_Y542 and STAT3_Y705\n", + "looking for paths in the network with length: 7 for node PTPN11_Y542 and STAT3_Y705\n", + "looking for paths in the network with length: 8 for node PTPN11_Y542 and STAT3_Y705\n", + "looking for paths in the network with length: 9 for node PTPN11_Y542 and STAT3_Y705\n", + "looking for paths in the network with length: 10 for node PTPN11_Y542 and STAT3_Y705\n", + "i_search = 4\n", + "Looking for paths with length: 0 for node PTPN11_Y542 and STAT3_Y705\n", + "i_search = 4\n", + "Looking for paths with length: 1 for node PTPN11_Y542 and STAT3_Y705\n", + "i_search = 4\n", + "Looking for paths with length: 2 for node PTPN11_Y542 and STAT3_Y705\n", + "i_search = 4\n", + "Looking for paths with length: 3 for node PTPN11_Y542 and STAT3_Y705\n", + "i_search = 4\n", + "Looking for paths with length: 4 for node PTPN11_Y542 and STAT3_Y705\n", + "looking for paths in the network with length: 0 for node PTPN11_Y542 and CHEK2_T68\n", + "looking for paths in the network with length: 1 for node PTPN11_Y542 and CHEK2_T68\n", + "looking for paths in the network with length: 2 for node PTPN11_Y542 and CHEK2_T68\n", + "looking for paths in the network with length: 3 for node PTPN11_Y542 and CHEK2_T68\n", + "looking for paths in the network with length: 4 for node PTPN11_Y542 and CHEK2_T68\n", + "looking for paths in the network with length: 5 for node PTPN11_Y542 and CHEK2_T68\n", + "looking for paths in the network with length: 6 for node PTPN11_Y542 and CHEK2_T68\n", + "looking for paths in the network with length: 7 for node PTPN11_Y542 and CHEK2_T68\n", + "looking for paths in the network with length: 8 for node PTPN11_Y542 and CHEK2_T68\n", + "looking for paths in the network with length: 9 for node PTPN11_Y542 and CHEK2_T68\n", + "looking for paths in the network with length: 10 for node PTPN11_Y542 and CHEK2_T68\n", + "i_search = 4\n", + "Looking for paths with length: 0 for node PTPN11_Y542 and CHEK2_T68\n", + "i_search = 4\n", + "Looking for paths with length: 1 for node PTPN11_Y542 and CHEK2_T68\n", + "i_search = 4\n", + "Looking for paths with length: 2 for node PTPN11_Y542 and CHEK2_T68\n", + "i_search = 4\n", + "Looking for paths with length: 3 for node PTPN11_Y542 and CHEK2_T68\n", + "i_search = 4\n", + "Looking for paths with length: 4 for node PTPN11_Y542 and CHEK2_T68\n", + "looking for paths in the network with length: 0 for node PTPN11_Y542 and RELA_S536\n", + "looking for paths in the network with length: 1 for node PTPN11_Y542 and RELA_S536\n", + "looking for paths in the network with length: 2 for node PTPN11_Y542 and RELA_S536\n", + "looking for paths in the network with length: 3 for node PTPN11_Y542 and RELA_S536\n", + "looking for paths in the network with length: 4 for node PTPN11_Y542 and RELA_S536\n", + "looking for paths in the network with length: 5 for node PTPN11_Y542 and RELA_S536\n", + "looking for paths in the network with length: 6 for node PTPN11_Y542 and RELA_S536\n", + "looking for paths in the network with length: 7 for node PTPN11_Y542 and RELA_S536\n", + "looking for paths in the network with length: 8 for node PTPN11_Y542 and RELA_S536\n", + "looking for paths in the network with length: 9 for node PTPN11_Y542 and RELA_S536\n", + "looking for paths in the network with length: 10 for node PTPN11_Y542 and RELA_S536\n", + "i_search = 4\n", + "Looking for paths with length: 0 for node PTPN11_Y542 and RELA_S536\n", + "i_search = 4\n", + "Looking for paths with length: 1 for node PTPN11_Y542 and RELA_S536\n", + "i_search = 4\n", + "Looking for paths with length: 2 for node PTPN11_Y542 and RELA_S536\n", + "i_search = 4\n", + "Looking for paths with length: 3 for node PTPN11_Y542 and RELA_S536\n", + "i_search = 4\n", + "Looking for paths with length: 4 for node PTPN11_Y542 and RELA_S536\n", + "looking for paths in the network with length: 0 for node PTPN11_Y542 and MARCKS_S170\n", + "looking for paths in the network with length: 1 for node PTPN11_Y542 and MARCKS_S170\n", + "looking for paths in the network with length: 2 for node PTPN11_Y542 and MARCKS_S170\n", + "looking for paths in the network with length: 3 for node PTPN11_Y542 and MARCKS_S170\n", + "looking for paths in the network with length: 4 for node PTPN11_Y542 and MARCKS_S170\n", + "looking for paths in the network with length: 5 for node PTPN11_Y542 and MARCKS_S170\n", + "looking for paths in the network with length: 6 for node PTPN11_Y542 and MARCKS_S170\n", + "looking for paths in the network with length: 7 for node PTPN11_Y542 and MARCKS_S170\n", + "looking for paths in the network with length: 8 for node PTPN11_Y542 and MARCKS_S170\n", + "looking for paths in the network with length: 9 for node PTPN11_Y542 and MARCKS_S170\n", + "looking for paths in the network with length: 10 for node PTPN11_Y542 and MARCKS_S170\n", + "i_search = 4\n", + "Looking for paths with length: 0 for node PTPN11_Y542 and MARCKS_S170\n", + "i_search = 4\n", + "Looking for paths with length: 1 for node PTPN11_Y542 and MARCKS_S170\n", + "i_search = 4\n", + "Looking for paths with length: 2 for node PTPN11_Y542 and MARCKS_S170\n", + "i_search = 4\n", + "Looking for paths with length: 3 for node PTPN11_Y542 and MARCKS_S170\n", + "i_search = 4\n", + "Looking for paths with length: 4 for node PTPN11_Y542 and MARCKS_S170\n", + "looking for paths in the network with length: 0 for node PTPN11_Y542 and SMAD3\n", + "looking for paths in the network with length: 1 for node PTPN11_Y542 and SMAD3\n", + "looking for paths in the network with length: 2 for node PTPN11_Y542 and SMAD3\n", + "looking for paths in the network with length: 3 for node PTPN11_Y542 and SMAD3\n", + "looking for paths in the network with length: 4 for node PTPN11_Y542 and SMAD3\n", + "looking for paths in the network with length: 5 for node PTPN11_Y542 and SMAD3\n", + "looking for paths in the network with length: 6 for node PTPN11_Y542 and SMAD3\n", + "looking for paths in the network with length: 7 for node PTPN11_Y542 and SMAD3\n", + "looking for paths in the network with length: 8 for node PTPN11_Y542 and SMAD3\n", + "looking for paths in the network with length: 9 for node PTPN11_Y542 and SMAD3\n", + "looking for paths in the network with length: 10 for node PTPN11_Y542 and SMAD3\n", + "i_search = 4\n", + "Looking for paths with length: 0 for node PTPN11_Y542 and SMAD3\n", + "i_search = 4\n", + "Looking for paths with length: 1 for node PTPN11_Y542 and SMAD3\n", + "i_search = 4\n", + "Looking for paths with length: 2 for node PTPN11_Y542 and SMAD3\n", + "i_search = 4\n", + "Looking for paths with length: 3 for node PTPN11_Y542 and SMAD3\n", + "i_search = 4\n", + "Looking for paths with length: 4 for node PTPN11_Y542 and SMAD3\n", + "looking for paths in the network with length: 0 for node PTPN11_Y542 and TP53\n", + "looking for paths in the network with length: 1 for node PTPN11_Y542 and TP53\n", + "looking for paths in the network with length: 2 for node PTPN11_Y542 and TP53\n", + "looking for paths in the network with length: 3 for node PTPN11_Y542 and TP53\n", + "looking for paths in the network with length: 4 for node PTPN11_Y542 and TP53\n", + "looking for paths in the network with length: 5 for node PTPN11_Y542 and TP53\n", + "looking for paths in the network with length: 6 for node PTPN11_Y542 and TP53\n", + "looking for paths in the network with length: 7 for node PTPN11_Y542 and TP53\n", + "looking for paths in the network with length: 8 for node PTPN11_Y542 and TP53\n", + "looking for paths in the network with length: 9 for node PTPN11_Y542 and TP53\n", + "looking for paths in the network with length: 10 for node PTPN11_Y542 and TP53\n", + "i_search = 4\n", + "Looking for paths with length: 0 for node PTPN11_Y542 and TP53\n", + "i_search = 4\n", + "Looking for paths with length: 1 for node PTPN11_Y542 and TP53\n", + "i_search = 4\n", + "Looking for paths with length: 2 for node PTPN11_Y542 and TP53\n", + "i_search = 4\n", + "Looking for paths with length: 3 for node PTPN11_Y542 and TP53\n", + "i_search = 4\n", + "Looking for paths with length: 4 for node PTPN11_Y542 and TP53\n", + "looking for paths in the network with length: 0 for node PTPN11_Y542 and AKT1S1\n", + "looking for paths in the network with length: 1 for node PTPN11_Y542 and AKT1S1\n", + "looking for paths in the network with length: 2 for node PTPN11_Y542 and AKT1S1\n", + "looking for paths in the network with length: 3 for node PTPN11_Y542 and AKT1S1\n", + "looking for paths in the network with length: 4 for node PTPN11_Y542 and AKT1S1\n", + "looking for paths in the network with length: 5 for node PTPN11_Y542 and AKT1S1\n", + "looking for paths in the network with length: 6 for node PTPN11_Y542 and AKT1S1\n", + "looking for paths in the network with length: 7 for node PTPN11_Y542 and AKT1S1\n", + "looking for paths in the network with length: 8 for node PTPN11_Y542 and AKT1S1\n", + "looking for paths in the network with length: 9 for node PTPN11_Y542 and AKT1S1\n", + "looking for paths in the network with length: 10 for node PTPN11_Y542 and AKT1S1\n", + "i_search = 4\n", + "Looking for paths with length: 0 for node PTPN11_Y542 and AKT1S1\n", + "i_search = 4\n", + "Looking for paths with length: 1 for node PTPN11_Y542 and AKT1S1\n", + "i_search = 4\n", + "Looking for paths with length: 2 for node PTPN11_Y542 and AKT1S1\n", + "i_search = 4\n", + "Looking for paths with length: 3 for node PTPN11_Y542 and AKT1S1\n", + "i_search = 4\n", + "Looking for paths with length: 4 for node PTPN11_Y542 and AKT1S1\n", + "looking for paths in the network with length: 0 for node PTPN11_Y542 and GSK3B\n", + "looking for paths in the network with length: 1 for node PTPN11_Y542 and GSK3B\n", + "looking for paths in the network with length: 2 for node PTPN11_Y542 and GSK3B\n", + "looking for paths in the network with length: 3 for node PTPN11_Y542 and GSK3B\n", + "looking for paths in the network with length: 4 for node PTPN11_Y542 and GSK3B\n", + "looking for paths in the network with length: 5 for node PTPN11_Y542 and GSK3B\n", + "looking for paths in the network with length: 6 for node PTPN11_Y542 and GSK3B\n", + "looking for paths in the network with length: 7 for node PTPN11_Y542 and GSK3B\n", + "looking for paths in the network with length: 8 for node PTPN11_Y542 and GSK3B\n", + "looking for paths in the network with length: 9 for node PTPN11_Y542 and GSK3B\n", + "looking for paths in the network with length: 10 for node PTPN11_Y542 and GSK3B\n", + "i_search = 4\n", + "Looking for paths with length: 0 for node PTPN11_Y542 and GSK3B\n", + "i_search = 4\n", + "Looking for paths with length: 1 for node PTPN11_Y542 and GSK3B\n", + "i_search = 4\n", + "Looking for paths with length: 2 for node PTPN11_Y542 and GSK3B\n", + "i_search = 4\n", + "Looking for paths with length: 3 for node PTPN11_Y542 and GSK3B\n", + "i_search = 4\n", + "Looking for paths with length: 4 for node PTPN11_Y542 and GSK3B\n", + "looking for paths in the network with length: 0 for node PTPN11_Y542 and AKT1\n", + "looking for paths in the network with length: 1 for node PTPN11_Y542 and AKT1\n", + "looking for paths in the network with length: 2 for node PTPN11_Y542 and AKT1\n", + "looking for paths in the network with length: 3 for node PTPN11_Y542 and AKT1\n", + "looking for paths in the network with length: 4 for node PTPN11_Y542 and AKT1\n", + "looking for paths in the network with length: 5 for node PTPN11_Y542 and AKT1\n", + "looking for paths in the network with length: 6 for node PTPN11_Y542 and AKT1\n", + "looking for paths in the network with length: 7 for node PTPN11_Y542 and AKT1\n", + "looking for paths in the network with length: 8 for node PTPN11_Y542 and AKT1\n", + "looking for paths in the network with length: 9 for node PTPN11_Y542 and AKT1\n", + "looking for paths in the network with length: 10 for node PTPN11_Y542 and AKT1\n", + "i_search = 4\n", + "Looking for paths with length: 0 for node PTPN11_Y542 and AKT1\n", + "i_search = 4\n", + "Looking for paths with length: 1 for node PTPN11_Y542 and AKT1\n", + "i_search = 4\n", + "Looking for paths with length: 2 for node PTPN11_Y542 and AKT1\n", + "i_search = 4\n", + "Looking for paths with length: 3 for node PTPN11_Y542 and AKT1\n", + "i_search = 4\n", + "Looking for paths with length: 4 for node PTPN11_Y542 and AKT1\n", + "looking for paths in the network with length: 0 for node PTPN11_Y542 and HSPB1\n", + "looking for paths in the network with length: 1 for node PTPN11_Y542 and HSPB1\n", + "looking for paths in the network with length: 2 for node PTPN11_Y542 and HSPB1\n", + "looking for paths in the network with length: 3 for node PTPN11_Y542 and HSPB1\n", + "looking for paths in the network with length: 4 for node PTPN11_Y542 and HSPB1\n", + "looking for paths in the network with length: 5 for node PTPN11_Y542 and HSPB1\n", + "looking for paths in the network with length: 6 for node PTPN11_Y542 and HSPB1\n", + "looking for paths in the network with length: 7 for node PTPN11_Y542 and HSPB1\n", + "looking for paths in the network with length: 8 for node PTPN11_Y542 and HSPB1\n", + "looking for paths in the network with length: 9 for node PTPN11_Y542 and HSPB1\n", + "looking for paths in the network with length: 10 for node PTPN11_Y542 and HSPB1\n", + "i_search = 4\n", + "Looking for paths with length: 0 for node PTPN11_Y542 and HSPB1\n", + "i_search = 4\n", + "Looking for paths with length: 1 for node PTPN11_Y542 and HSPB1\n", + "i_search = 4\n", + "Looking for paths with length: 2 for node PTPN11_Y542 and HSPB1\n", + "i_search = 4\n", + "Looking for paths with length: 3 for node PTPN11_Y542 and HSPB1\n", + "i_search = 4\n", + "Looking for paths with length: 4 for node PTPN11_Y542 and HSPB1\n", + "looking for paths in the network with length: 0 for node PTPN11_Y542 and MAPK14\n", + "looking for paths in the network with length: 1 for node PTPN11_Y542 and MAPK14\n", + "looking for paths in the network with length: 2 for node PTPN11_Y542 and MAPK14\n", + "looking for paths in the network with length: 3 for node PTPN11_Y542 and MAPK14\n", + "looking for paths in the network with length: 4 for node PTPN11_Y542 and MAPK14\n", + "looking for paths in the network with length: 5 for node PTPN11_Y542 and MAPK14\n", + "looking for paths in the network with length: 6 for node PTPN11_Y542 and MAPK14\n", + "looking for paths in the network with length: 7 for node PTPN11_Y542 and MAPK14\n", + "looking for paths in the network with length: 8 for node PTPN11_Y542 and MAPK14\n", + "looking for paths in the network with length: 9 for node PTPN11_Y542 and MAPK14\n", + "looking for paths in the network with length: 10 for node PTPN11_Y542 and MAPK14\n", + "i_search = 4\n", + "Looking for paths with length: 0 for node PTPN11_Y542 and MAPK14\n", + "i_search = 4\n", + "Looking for paths with length: 1 for node PTPN11_Y542 and MAPK14\n", + "i_search = 4\n", + "Looking for paths with length: 2 for node PTPN11_Y542 and MAPK14\n", + "i_search = 4\n", + "Looking for paths with length: 3 for node PTPN11_Y542 and MAPK14\n", + "i_search = 4\n", + "Looking for paths with length: 4 for node PTPN11_Y542 and MAPK14\n", + "looking for paths in the network with length: 0 for node PTPN11_Y542 and MAP2K1\n", + "looking for paths in the network with length: 1 for node PTPN11_Y542 and MAP2K1\n", + "looking for paths in the network with length: 2 for node PTPN11_Y542 and MAP2K1\n", + "looking for paths in the network with length: 3 for node PTPN11_Y542 and MAP2K1\n", + "looking for paths in the network with length: 4 for node PTPN11_Y542 and MAP2K1\n", + "looking for paths in the network with length: 5 for node PTPN11_Y542 and MAP2K1\n", + "looking for paths in the network with length: 6 for node PTPN11_Y542 and MAP2K1\n", + "looking for paths in the network with length: 7 for node PTPN11_Y542 and MAP2K1\n", + "looking for paths in the network with length: 8 for node PTPN11_Y542 and MAP2K1\n", + "looking for paths in the network with length: 9 for node PTPN11_Y542 and MAP2K1\n", + "looking for paths in the network with length: 10 for node PTPN11_Y542 and MAP2K1\n", + "i_search = 4\n", + "Looking for paths with length: 0 for node PTPN11_Y542 and MAP2K1\n", + "i_search = 4\n", + "Looking for paths with length: 1 for node PTPN11_Y542 and MAP2K1\n", + "i_search = 4\n", + "Looking for paths with length: 2 for node PTPN11_Y542 and MAP2K1\n", + "i_search = 4\n", + "Looking for paths with length: 3 for node PTPN11_Y542 and MAP2K1\n", + "i_search = 4\n", + "Looking for paths with length: 4 for node PTPN11_Y542 and MAP2K1\n", + "looking for paths in the network with length: 0 for node PTPN11_Y542 and RPS6KA1\n", + "looking for paths in the network with length: 1 for node PTPN11_Y542 and RPS6KA1\n", + "looking for paths in the network with length: 2 for node PTPN11_Y542 and RPS6KA1\n", + "looking for paths in the network with length: 3 for node PTPN11_Y542 and RPS6KA1\n", + "looking for paths in the network with length: 4 for node PTPN11_Y542 and RPS6KA1\n", + "looking for paths in the network with length: 5 for node PTPN11_Y542 and RPS6KA1\n", + "looking for paths in the network with length: 6 for node PTPN11_Y542 and RPS6KA1\n", + "looking for paths in the network with length: 7 for node PTPN11_Y542 and RPS6KA1\n", + "looking for paths in the network with length: 8 for node PTPN11_Y542 and RPS6KA1\n", + "looking for paths in the network with length: 9 for node PTPN11_Y542 and RPS6KA1\n", + "looking for paths in the network with length: 10 for node PTPN11_Y542 and RPS6KA1\n", + "i_search = 4\n", + "Looking for paths with length: 0 for node PTPN11_Y542 and RPS6KA1\n", + "i_search = 4\n", + "Looking for paths with length: 1 for node PTPN11_Y542 and RPS6KA1\n", + "i_search = 4\n", + "Looking for paths with length: 2 for node PTPN11_Y542 and RPS6KA1\n", + "i_search = 4\n", + "Looking for paths with length: 3 for node PTPN11_Y542 and RPS6KA1\n", + "i_search = 4\n", + "Looking for paths with length: 4 for node PTPN11_Y542 and RPS6KA1\n", + "looking for paths in the network with length: 0 for node PTPN11_Y542 and CREB1\n", + "looking for paths in the network with length: 1 for node PTPN11_Y542 and CREB1\n", + "looking for paths in the network with length: 2 for node PTPN11_Y542 and CREB1\n", + "looking for paths in the network with length: 3 for node PTPN11_Y542 and CREB1\n", + "looking for paths in the network with length: 4 for node PTPN11_Y542 and CREB1\n", + "looking for paths in the network with length: 5 for node PTPN11_Y542 and CREB1\n", + "looking for paths in the network with length: 6 for node PTPN11_Y542 and CREB1\n", + "looking for paths in the network with length: 7 for node PTPN11_Y542 and CREB1\n", + "looking for paths in the network with length: 8 for node PTPN11_Y542 and CREB1\n", + "looking for paths in the network with length: 9 for node PTPN11_Y542 and CREB1\n", + "looking for paths in the network with length: 10 for node PTPN11_Y542 and CREB1\n", + "i_search = 4\n", + "Looking for paths with length: 0 for node PTPN11_Y542 and CREB1\n", + "i_search = 4\n", + "Looking for paths with length: 1 for node PTPN11_Y542 and CREB1\n", + "i_search = 4\n", + "Looking for paths with length: 2 for node PTPN11_Y542 and CREB1\n", + "i_search = 4\n", + "Looking for paths with length: 3 for node PTPN11_Y542 and CREB1\n", + "i_search = 4\n", + "Looking for paths with length: 4 for node PTPN11_Y542 and CREB1\n", + "looking for paths in the network with length: 0 for node PTPN11_Y542 and NFKBIA\n", + "looking for paths in the network with length: 1 for node PTPN11_Y542 and NFKBIA\n", + "looking for paths in the network with length: 2 for node PTPN11_Y542 and NFKBIA\n", + "looking for paths in the network with length: 3 for node PTPN11_Y542 and NFKBIA\n", + "looking for paths in the network with length: 4 for node PTPN11_Y542 and NFKBIA\n", + "looking for paths in the network with length: 5 for node PTPN11_Y542 and NFKBIA\n", + "looking for paths in the network with length: 6 for node PTPN11_Y542 and NFKBIA\n", + "looking for paths in the network with length: 7 for node PTPN11_Y542 and NFKBIA\n", + "looking for paths in the network with length: 8 for node PTPN11_Y542 and NFKBIA\n", + "looking for paths in the network with length: 9 for node PTPN11_Y542 and NFKBIA\n", + "looking for paths in the network with length: 10 for node PTPN11_Y542 and NFKBIA\n", + "i_search = 4\n", + "Looking for paths with length: 0 for node PTPN11_Y542 and NFKBIA\n", + "i_search = 4\n", + "Looking for paths with length: 1 for node PTPN11_Y542 and NFKBIA\n", + "i_search = 4\n", + "Looking for paths with length: 2 for node PTPN11_Y542 and NFKBIA\n", + "i_search = 4\n", + "Looking for paths with length: 3 for node PTPN11_Y542 and NFKBIA\n", + "i_search = 4\n", + "Looking for paths with length: 4 for node PTPN11_Y542 and NFKBIA\n", + "looking for paths in the network with length: 0 for node PTPN11_Y542 and MTOR\n", + "looking for paths in the network with length: 1 for node PTPN11_Y542 and MTOR\n", + "looking for paths in the network with length: 2 for node PTPN11_Y542 and MTOR\n", + "looking for paths in the network with length: 3 for node PTPN11_Y542 and MTOR\n", + "looking for paths in the network with length: 4 for node PTPN11_Y542 and MTOR\n", + "looking for paths in the network with length: 5 for node PTPN11_Y542 and MTOR\n", + "looking for paths in the network with length: 6 for node PTPN11_Y542 and MTOR\n", + "looking for paths in the network with length: 7 for node PTPN11_Y542 and MTOR\n", + "looking for paths in the network with length: 8 for node PTPN11_Y542 and MTOR\n", + "looking for paths in the network with length: 9 for node PTPN11_Y542 and MTOR\n", + "looking for paths in the network with length: 10 for node PTPN11_Y542 and MTOR\n", + "i_search = 4\n", + "Looking for paths with length: 0 for node PTPN11_Y542 and MTOR\n", + "i_search = 4\n", + "Looking for paths with length: 1 for node PTPN11_Y542 and MTOR\n", + "i_search = 4\n", + "Looking for paths with length: 2 for node PTPN11_Y542 and MTOR\n", + "i_search = 4\n", + "Looking for paths with length: 3 for node PTPN11_Y542 and MTOR\n", + "i_search = 4\n", + "Looking for paths with length: 4 for node PTPN11_Y542 and MTOR\n", + "looking for paths in the network with length: 0 for node PTPN11_Y542 and JUN\n", + "looking for paths in the network with length: 1 for node PTPN11_Y542 and JUN\n", + "looking for paths in the network with length: 2 for node PTPN11_Y542 and JUN\n", + "looking for paths in the network with length: 3 for node PTPN11_Y542 and JUN\n", + "looking for paths in the network with length: 4 for node PTPN11_Y542 and JUN\n", + "looking for paths in the network with length: 5 for node PTPN11_Y542 and JUN\n", + "looking for paths in the network with length: 6 for node PTPN11_Y542 and JUN\n", + "looking for paths in the network with length: 7 for node PTPN11_Y542 and JUN\n", + "looking for paths in the network with length: 8 for node PTPN11_Y542 and JUN\n", + "looking for paths in the network with length: 9 for node PTPN11_Y542 and JUN\n", + "looking for paths in the network with length: 10 for node PTPN11_Y542 and JUN\n", + "i_search = 4\n", + "Looking for paths with length: 0 for node PTPN11_Y542 and JUN\n", + "i_search = 4\n", + "Looking for paths with length: 1 for node PTPN11_Y542 and JUN\n", + "i_search = 4\n", + "Looking for paths with length: 2 for node PTPN11_Y542 and JUN\n", + "i_search = 4\n", + "Looking for paths with length: 3 for node PTPN11_Y542 and JUN\n", + "i_search = 4\n", + "Looking for paths with length: 4 for node PTPN11_Y542 and JUN\n", + "looking for paths in the network with length: 0 for node PTPN11_Y542 and EGFR\n", + "looking for paths in the network with length: 1 for node PTPN11_Y542 and EGFR\n", + "looking for paths in the network with length: 2 for node PTPN11_Y542 and EGFR\n", + "looking for paths in the network with length: 3 for node PTPN11_Y542 and EGFR\n", + "looking for paths in the network with length: 4 for node PTPN11_Y542 and EGFR\n", + "looking for paths in the network with length: 5 for node PTPN11_Y542 and EGFR\n", + "looking for paths in the network with length: 6 for node PTPN11_Y542 and EGFR\n", + "looking for paths in the network with length: 7 for node PTPN11_Y542 and EGFR\n", + "looking for paths in the network with length: 8 for node PTPN11_Y542 and EGFR\n", + "looking for paths in the network with length: 9 for node PTPN11_Y542 and EGFR\n", + "looking for paths in the network with length: 10 for node PTPN11_Y542 and EGFR\n", + "i_search = 4\n", + "Looking for paths with length: 0 for node PTPN11_Y542 and EGFR\n", + "i_search = 4\n", + "Looking for paths with length: 1 for node PTPN11_Y542 and EGFR\n", + "i_search = 4\n", + "Looking for paths with length: 2 for node PTPN11_Y542 and EGFR\n", + "i_search = 4\n", + "Looking for paths with length: 3 for node PTPN11_Y542 and EGFR\n", + "i_search = 4\n", + "Looking for paths with length: 4 for node PTPN11_Y542 and EGFR\n", + "looking for paths in the network with length: 0 for node PTPN11_Y542 and MAPK3\n", + "looking for paths in the network with length: 1 for node PTPN11_Y542 and MAPK3\n", + "looking for paths in the network with length: 2 for node PTPN11_Y542 and MAPK3\n", + "looking for paths in the network with length: 3 for node PTPN11_Y542 and MAPK3\n", + "looking for paths in the network with length: 4 for node PTPN11_Y542 and MAPK3\n", + "looking for paths in the network with length: 5 for node PTPN11_Y542 and MAPK3\n", + "looking for paths in the network with length: 6 for node PTPN11_Y542 and MAPK3\n", + "looking for paths in the network with length: 7 for node PTPN11_Y542 and MAPK3\n", + "looking for paths in the network with length: 8 for node PTPN11_Y542 and MAPK3\n", + "looking for paths in the network with length: 9 for node PTPN11_Y542 and MAPK3\n", + "looking for paths in the network with length: 10 for node PTPN11_Y542 and MAPK3\n", + "i_search = 4\n", + "Looking for paths with length: 0 for node PTPN11_Y542 and MAPK3\n", + "i_search = 4\n", + "Looking for paths with length: 1 for node PTPN11_Y542 and MAPK3\n", + "i_search = 4\n", + "Looking for paths with length: 2 for node PTPN11_Y542 and MAPK3\n", + "i_search = 4\n", + "Looking for paths with length: 3 for node PTPN11_Y542 and MAPK3\n", + "i_search = 4\n", + "Looking for paths with length: 4 for node PTPN11_Y542 and MAPK3\n", + "looking for paths in the network with length: 0 for node PTPN11_Y542 and PTPN11\n", + "looking for paths in the network with length: 1 for node PTPN11_Y542 and PTPN11\n", + "looking for paths in the network with length: 2 for node PTPN11_Y542 and PTPN11\n", + "looking for paths in the network with length: 3 for node PTPN11_Y542 and PTPN11\n", + "looking for paths in the network with length: 4 for node PTPN11_Y542 and PTPN11\n", + "looking for paths in the network with length: 5 for node PTPN11_Y542 and PTPN11\n", + "looking for paths in the network with length: 6 for node PTPN11_Y542 and PTPN11\n", + "looking for paths in the network with length: 7 for node PTPN11_Y542 and PTPN11\n", + "looking for paths in the network with length: 8 for node PTPN11_Y542 and PTPN11\n", + "looking for paths in the network with length: 9 for node PTPN11_Y542 and PTPN11\n", + "looking for paths in the network with length: 10 for node PTPN11_Y542 and PTPN11\n", + "i_search = 4\n", + "Looking for paths with length: 0 for node PTPN11_Y542 and PTPN11\n", + "i_search = 4\n", + "Looking for paths with length: 1 for node PTPN11_Y542 and PTPN11\n", + "i_search = 4\n", + "Looking for paths with length: 2 for node PTPN11_Y542 and PTPN11\n", + "i_search = 4\n", + "Looking for paths with length: 3 for node PTPN11_Y542 and PTPN11\n", + "i_search = 4\n", + "Looking for paths with length: 4 for node PTPN11_Y542 and PTPN11\n", + "looking for paths in the network with length: 0 for node PTPN11_Y542 and STAT3\n", + "looking for paths in the network with length: 1 for node PTPN11_Y542 and STAT3\n", + "looking for paths in the network with length: 2 for node PTPN11_Y542 and STAT3\n", + "looking for paths in the network with length: 3 for node PTPN11_Y542 and STAT3\n", + "looking for paths in the network with length: 4 for node PTPN11_Y542 and STAT3\n", + "looking for paths in the network with length: 5 for node PTPN11_Y542 and STAT3\n", + "looking for paths in the network with length: 6 for node PTPN11_Y542 and STAT3\n", + "looking for paths in the network with length: 7 for node PTPN11_Y542 and STAT3\n", + "looking for paths in the network with length: 8 for node PTPN11_Y542 and STAT3\n", + "looking for paths in the network with length: 9 for node PTPN11_Y542 and STAT3\n", + "looking for paths in the network with length: 10 for node PTPN11_Y542 and STAT3\n", + "i_search = 4\n", + "Looking for paths with length: 0 for node PTPN11_Y542 and STAT3\n", + "i_search = 4\n", + "Looking for paths with length: 1 for node PTPN11_Y542 and STAT3\n", + "i_search = 4\n", + "Looking for paths with length: 2 for node PTPN11_Y542 and STAT3\n", + "i_search = 4\n", + "Looking for paths with length: 3 for node PTPN11_Y542 and STAT3\n", + "i_search = 4\n", + "Looking for paths with length: 4 for node PTPN11_Y542 and STAT3\n", + "looking for paths in the network with length: 0 for node PTPN11_Y542 and CHEK2\n", + "looking for paths in the network with length: 1 for node PTPN11_Y542 and CHEK2\n", + "looking for paths in the network with length: 2 for node PTPN11_Y542 and CHEK2\n", + "looking for paths in the network with length: 3 for node PTPN11_Y542 and CHEK2\n", + "looking for paths in the network with length: 4 for node PTPN11_Y542 and CHEK2\n", + "looking for paths in the network with length: 5 for node PTPN11_Y542 and CHEK2\n", + "looking for paths in the network with length: 6 for node PTPN11_Y542 and CHEK2\n", + "looking for paths in the network with length: 7 for node PTPN11_Y542 and CHEK2\n", + "looking for paths in the network with length: 8 for node PTPN11_Y542 and CHEK2\n", + "looking for paths in the network with length: 9 for node PTPN11_Y542 and CHEK2\n", + "looking for paths in the network with length: 10 for node PTPN11_Y542 and CHEK2\n", + "i_search = 4\n", + "Looking for paths with length: 0 for node PTPN11_Y542 and CHEK2\n", + "i_search = 4\n", + "Looking for paths with length: 1 for node PTPN11_Y542 and CHEK2\n", + "i_search = 4\n", + "Looking for paths with length: 2 for node PTPN11_Y542 and CHEK2\n", + "i_search = 4\n", + "Looking for paths with length: 3 for node PTPN11_Y542 and CHEK2\n", + "i_search = 4\n", + "Looking for paths with length: 4 for node PTPN11_Y542 and CHEK2\n", + "looking for paths in the network with length: 0 for node PTPN11_Y542 and RELA\n", + "looking for paths in the network with length: 1 for node PTPN11_Y542 and RELA\n", + "looking for paths in the network with length: 2 for node PTPN11_Y542 and RELA\n", + "looking for paths in the network with length: 3 for node PTPN11_Y542 and RELA\n", + "looking for paths in the network with length: 4 for node PTPN11_Y542 and RELA\n", + "looking for paths in the network with length: 5 for node PTPN11_Y542 and RELA\n", + "looking for paths in the network with length: 6 for node PTPN11_Y542 and RELA\n", + "looking for paths in the network with length: 7 for node PTPN11_Y542 and RELA\n", + "looking for paths in the network with length: 8 for node PTPN11_Y542 and RELA\n", + "looking for paths in the network with length: 9 for node PTPN11_Y542 and RELA\n", + "looking for paths in the network with length: 10 for node PTPN11_Y542 and RELA\n", + "i_search = 4\n", + "Looking for paths with length: 0 for node PTPN11_Y542 and RELA\n", + "i_search = 4\n", + "Looking for paths with length: 1 for node PTPN11_Y542 and RELA\n", + "i_search = 4\n", + "Looking for paths with length: 2 for node PTPN11_Y542 and RELA\n", + "i_search = 4\n", + "Looking for paths with length: 3 for node PTPN11_Y542 and RELA\n", + "i_search = 4\n", + "Looking for paths with length: 4 for node PTPN11_Y542 and RELA\n", + "looking for paths in the network with length: 0 for node PTPN11_Y542 and MARCKS\n", + "looking for paths in the network with length: 1 for node PTPN11_Y542 and MARCKS\n", + "looking for paths in the network with length: 2 for node PTPN11_Y542 and MARCKS\n", + "looking for paths in the network with length: 3 for node PTPN11_Y542 and MARCKS\n", + "looking for paths in the network with length: 4 for node PTPN11_Y542 and MARCKS\n", + "looking for paths in the network with length: 5 for node PTPN11_Y542 and MARCKS\n", + "looking for paths in the network with length: 6 for node PTPN11_Y542 and MARCKS\n", + "looking for paths in the network with length: 7 for node PTPN11_Y542 and MARCKS\n", + "looking for paths in the network with length: 8 for node PTPN11_Y542 and MARCKS\n", + "looking for paths in the network with length: 9 for node PTPN11_Y542 and MARCKS\n", + "looking for paths in the network with length: 10 for node PTPN11_Y542 and MARCKS\n", + "i_search = 4\n", + "Looking for paths with length: 0 for node PTPN11_Y542 and MARCKS\n", + "i_search = 4\n", + "Looking for paths with length: 1 for node PTPN11_Y542 and MARCKS\n", + "i_search = 4\n", + "Looking for paths with length: 2 for node PTPN11_Y542 and MARCKS\n", + "i_search = 4\n", + "Looking for paths with length: 3 for node PTPN11_Y542 and MARCKS\n", + "i_search = 4\n", + "Looking for paths with length: 4 for node PTPN11_Y542 and MARCKS\n", + "looking for paths in the network with length: 0 for node STAT3_Y705 and CHEK2_T68\n", + "looking for paths in the network with length: 1 for node STAT3_Y705 and CHEK2_T68\n", + "looking for paths in the network with length: 2 for node STAT3_Y705 and CHEK2_T68\n", + "looking for paths in the network with length: 3 for node STAT3_Y705 and CHEK2_T68\n", + "looking for paths in the network with length: 4 for node STAT3_Y705 and CHEK2_T68\n", + "looking for paths in the network with length: 5 for node STAT3_Y705 and CHEK2_T68\n", + "looking for paths in the network with length: 6 for node STAT3_Y705 and CHEK2_T68\n", + "looking for paths in the network with length: 7 for node STAT3_Y705 and CHEK2_T68\n", + "looking for paths in the network with length: 8 for node STAT3_Y705 and CHEK2_T68\n", + "looking for paths in the network with length: 9 for node STAT3_Y705 and CHEK2_T68\n", + "looking for paths in the network with length: 10 for node STAT3_Y705 and CHEK2_T68\n", + "i_search = 4\n", + "Looking for paths with length: 0 for node STAT3_Y705 and CHEK2_T68\n", + "i_search = 4\n", + "Looking for paths with length: 1 for node STAT3_Y705 and CHEK2_T68\n", + "i_search = 4\n", + "Looking for paths with length: 2 for node STAT3_Y705 and CHEK2_T68\n", + "i_search = 4\n", + "Looking for paths with length: 3 for node STAT3_Y705 and CHEK2_T68\n", + "i_search = 4\n", + "Looking for paths with length: 4 for node STAT3_Y705 and CHEK2_T68\n", + "looking for paths in the network with length: 0 for node STAT3_Y705 and RELA_S536\n", + "looking for paths in the network with length: 1 for node STAT3_Y705 and RELA_S536\n", + "looking for paths in the network with length: 2 for node STAT3_Y705 and RELA_S536\n", + "looking for paths in the network with length: 3 for node STAT3_Y705 and RELA_S536\n", + "looking for paths in the network with length: 4 for node STAT3_Y705 and RELA_S536\n", + "looking for paths in the network with length: 5 for node STAT3_Y705 and RELA_S536\n", + "looking for paths in the network with length: 6 for node STAT3_Y705 and RELA_S536\n", + "looking for paths in the network with length: 7 for node STAT3_Y705 and RELA_S536\n", + "looking for paths in the network with length: 8 for node STAT3_Y705 and RELA_S536\n", + "looking for paths in the network with length: 9 for node STAT3_Y705 and RELA_S536\n", + "looking for paths in the network with length: 10 for node STAT3_Y705 and RELA_S536\n", + "i_search = 4\n", + "Looking for paths with length: 0 for node STAT3_Y705 and RELA_S536\n", + "i_search = 4\n", + "Looking for paths with length: 1 for node STAT3_Y705 and RELA_S536\n", + "i_search = 4\n", + "Looking for paths with length: 2 for node STAT3_Y705 and RELA_S536\n", + "i_search = 4\n", + "Looking for paths with length: 3 for node STAT3_Y705 and RELA_S536\n", + "i_search = 4\n", + "Looking for paths with length: 4 for node STAT3_Y705 and RELA_S536\n", + "looking for paths in the network with length: 0 for node STAT3_Y705 and MARCKS_S170\n", + "looking for paths in the network with length: 1 for node STAT3_Y705 and MARCKS_S170\n", + "looking for paths in the network with length: 2 for node STAT3_Y705 and MARCKS_S170\n", + "looking for paths in the network with length: 3 for node STAT3_Y705 and MARCKS_S170\n", + "looking for paths in the network with length: 4 for node STAT3_Y705 and MARCKS_S170\n", + "looking for paths in the network with length: 5 for node STAT3_Y705 and MARCKS_S170\n", + "looking for paths in the network with length: 6 for node STAT3_Y705 and MARCKS_S170\n", + "looking for paths in the network with length: 7 for node STAT3_Y705 and MARCKS_S170\n", + "looking for paths in the network with length: 8 for node STAT3_Y705 and MARCKS_S170\n", + "looking for paths in the network with length: 9 for node STAT3_Y705 and MARCKS_S170\n", + "looking for paths in the network with length: 10 for node STAT3_Y705 and MARCKS_S170\n", + "i_search = 4\n", + "Looking for paths with length: 0 for node STAT3_Y705 and MARCKS_S170\n", + "i_search = 4\n", + "Looking for paths with length: 1 for node STAT3_Y705 and MARCKS_S170\n", + "i_search = 4\n", + "Looking for paths with length: 2 for node STAT3_Y705 and MARCKS_S170\n", + "i_search = 4\n", + "Looking for paths with length: 3 for node STAT3_Y705 and MARCKS_S170\n", + "i_search = 4\n", + "Looking for paths with length: 4 for node STAT3_Y705 and MARCKS_S170\n", + "looking for paths in the network with length: 0 for node STAT3_Y705 and SMAD3\n", + "looking for paths in the network with length: 1 for node STAT3_Y705 and SMAD3\n", + "looking for paths in the network with length: 2 for node STAT3_Y705 and SMAD3\n", + "looking for paths in the network with length: 3 for node STAT3_Y705 and SMAD3\n", + "looking for paths in the network with length: 4 for node STAT3_Y705 and SMAD3\n", + "looking for paths in the network with length: 5 for node STAT3_Y705 and SMAD3\n", + "looking for paths in the network with length: 6 for node STAT3_Y705 and SMAD3\n", + "looking for paths in the network with length: 7 for node STAT3_Y705 and SMAD3\n", + "looking for paths in the network with length: 8 for node STAT3_Y705 and SMAD3\n", + "looking for paths in the network with length: 9 for node STAT3_Y705 and SMAD3\n", + "looking for paths in the network with length: 10 for node STAT3_Y705 and SMAD3\n", + "i_search = 4\n", + "Looking for paths with length: 0 for node STAT3_Y705 and SMAD3\n", + "i_search = 4\n", + "Looking for paths with length: 1 for node STAT3_Y705 and SMAD3\n", + "i_search = 4\n", + "Looking for paths with length: 2 for node STAT3_Y705 and SMAD3\n", + "i_search = 4\n", + "Looking for paths with length: 3 for node STAT3_Y705 and SMAD3\n", + "i_search = 4\n", + "Looking for paths with length: 4 for node STAT3_Y705 and SMAD3\n", + "looking for paths in the network with length: 0 for node STAT3_Y705 and TP53\n", + "looking for paths in the network with length: 1 for node STAT3_Y705 and TP53\n", + "looking for paths in the network with length: 2 for node STAT3_Y705 and TP53\n", + "looking for paths in the network with length: 3 for node STAT3_Y705 and TP53\n", + "looking for paths in the network with length: 4 for node STAT3_Y705 and TP53\n", + "looking for paths in the network with length: 5 for node STAT3_Y705 and TP53\n", + "looking for paths in the network with length: 6 for node STAT3_Y705 and TP53\n", + "looking for paths in the network with length: 7 for node STAT3_Y705 and TP53\n", + "looking for paths in the network with length: 8 for node STAT3_Y705 and TP53\n", + "looking for paths in the network with length: 9 for node STAT3_Y705 and TP53\n", + "looking for paths in the network with length: 10 for node STAT3_Y705 and TP53\n", + "i_search = 4\n", + "Looking for paths with length: 0 for node STAT3_Y705 and TP53\n", + "i_search = 4\n", + "Looking for paths with length: 1 for node STAT3_Y705 and TP53\n", + "i_search = 4\n", + "Looking for paths with length: 2 for node STAT3_Y705 and TP53\n", + "i_search = 4\n", + "Looking for paths with length: 3 for node STAT3_Y705 and TP53\n", + "i_search = 4\n", + "Looking for paths with length: 4 for node STAT3_Y705 and TP53\n", + "looking for paths in the network with length: 0 for node STAT3_Y705 and AKT1S1\n", + "looking for paths in the network with length: 1 for node STAT3_Y705 and AKT1S1\n", + "looking for paths in the network with length: 2 for node STAT3_Y705 and AKT1S1\n", + "looking for paths in the network with length: 3 for node STAT3_Y705 and AKT1S1\n", + "looking for paths in the network with length: 4 for node STAT3_Y705 and AKT1S1\n", + "looking for paths in the network with length: 5 for node STAT3_Y705 and AKT1S1\n", + "looking for paths in the network with length: 6 for node STAT3_Y705 and AKT1S1\n", + "looking for paths in the network with length: 7 for node STAT3_Y705 and AKT1S1\n", + "looking for paths in the network with length: 8 for node STAT3_Y705 and AKT1S1\n", + "looking for paths in the network with length: 9 for node STAT3_Y705 and AKT1S1\n", + "looking for paths in the network with length: 10 for node STAT3_Y705 and AKT1S1\n", + "i_search = 4\n", + "Looking for paths with length: 0 for node STAT3_Y705 and AKT1S1\n", + "i_search = 4\n", + "Looking for paths with length: 1 for node STAT3_Y705 and AKT1S1\n", + "i_search = 4\n", + "Looking for paths with length: 2 for node STAT3_Y705 and AKT1S1\n", + "i_search = 4\n", + "Looking for paths with length: 3 for node STAT3_Y705 and AKT1S1\n", + "i_search = 4\n", + "Looking for paths with length: 4 for node STAT3_Y705 and AKT1S1\n", + "looking for paths in the network with length: 0 for node STAT3_Y705 and GSK3B\n", + "looking for paths in the network with length: 1 for node STAT3_Y705 and GSK3B\n", + "looking for paths in the network with length: 2 for node STAT3_Y705 and GSK3B\n", + "looking for paths in the network with length: 3 for node STAT3_Y705 and GSK3B\n", + "looking for paths in the network with length: 4 for node STAT3_Y705 and GSK3B\n", + "looking for paths in the network with length: 5 for node STAT3_Y705 and GSK3B\n", + "looking for paths in the network with length: 6 for node STAT3_Y705 and GSK3B\n", + "looking for paths in the network with length: 7 for node STAT3_Y705 and GSK3B\n", + "looking for paths in the network with length: 8 for node STAT3_Y705 and GSK3B\n", + "looking for paths in the network with length: 9 for node STAT3_Y705 and GSK3B\n", + "looking for paths in the network with length: 10 for node STAT3_Y705 and GSK3B\n", + "i_search = 4\n", + "Looking for paths with length: 0 for node STAT3_Y705 and GSK3B\n", + "i_search = 4\n", + "Looking for paths with length: 1 for node STAT3_Y705 and GSK3B\n", + "i_search = 4\n", + "Looking for paths with length: 2 for node STAT3_Y705 and GSK3B\n", + "i_search = 4\n", + "Looking for paths with length: 3 for node STAT3_Y705 and GSK3B\n", + "i_search = 4\n", + "Looking for paths with length: 4 for node STAT3_Y705 and GSK3B\n", + "looking for paths in the network with length: 0 for node STAT3_Y705 and AKT1\n", + "looking for paths in the network with length: 1 for node STAT3_Y705 and AKT1\n", + "looking for paths in the network with length: 2 for node STAT3_Y705 and AKT1\n", + "looking for paths in the network with length: 3 for node STAT3_Y705 and AKT1\n", + "looking for paths in the network with length: 4 for node STAT3_Y705 and AKT1\n", + "looking for paths in the network with length: 5 for node STAT3_Y705 and AKT1\n", + "looking for paths in the network with length: 6 for node STAT3_Y705 and AKT1\n", + "looking for paths in the network with length: 7 for node STAT3_Y705 and AKT1\n", + "looking for paths in the network with length: 8 for node STAT3_Y705 and AKT1\n", + "looking for paths in the network with length: 9 for node STAT3_Y705 and AKT1\n", + "looking for paths in the network with length: 10 for node STAT3_Y705 and AKT1\n", + "i_search = 4\n", + "Looking for paths with length: 0 for node STAT3_Y705 and AKT1\n", + "i_search = 4\n", + "Looking for paths with length: 1 for node STAT3_Y705 and AKT1\n", + "i_search = 4\n", + "Looking for paths with length: 2 for node STAT3_Y705 and AKT1\n", + "i_search = 4\n", + "Looking for paths with length: 3 for node STAT3_Y705 and AKT1\n", + "i_search = 4\n", + "Looking for paths with length: 4 for node STAT3_Y705 and AKT1\n", + "looking for paths in the network with length: 0 for node STAT3_Y705 and HSPB1\n", + "looking for paths in the network with length: 1 for node STAT3_Y705 and HSPB1\n", + "looking for paths in the network with length: 2 for node STAT3_Y705 and HSPB1\n", + "looking for paths in the network with length: 3 for node STAT3_Y705 and HSPB1\n", + "looking for paths in the network with length: 4 for node STAT3_Y705 and HSPB1\n", + "looking for paths in the network with length: 5 for node STAT3_Y705 and HSPB1\n", + "looking for paths in the network with length: 6 for node STAT3_Y705 and HSPB1\n", + "looking for paths in the network with length: 7 for node STAT3_Y705 and HSPB1\n", + "looking for paths in the network with length: 8 for node STAT3_Y705 and HSPB1\n", + "looking for paths in the network with length: 9 for node STAT3_Y705 and HSPB1\n", + "looking for paths in the network with length: 10 for node STAT3_Y705 and HSPB1\n", + "i_search = 4\n", + "Looking for paths with length: 0 for node STAT3_Y705 and HSPB1\n", + "i_search = 4\n", + "Looking for paths with length: 1 for node STAT3_Y705 and HSPB1\n", + "i_search = 4\n", + "Looking for paths with length: 2 for node STAT3_Y705 and HSPB1\n", + "i_search = 4\n", + "Looking for paths with length: 3 for node STAT3_Y705 and HSPB1\n", + "i_search = 4\n", + "Looking for paths with length: 4 for node STAT3_Y705 and HSPB1\n", + "looking for paths in the network with length: 0 for node STAT3_Y705 and MAPK14\n", + "looking for paths in the network with length: 1 for node STAT3_Y705 and MAPK14\n", + "looking for paths in the network with length: 2 for node STAT3_Y705 and MAPK14\n", + "looking for paths in the network with length: 3 for node STAT3_Y705 and MAPK14\n", + "looking for paths in the network with length: 4 for node STAT3_Y705 and MAPK14\n", + "looking for paths in the network with length: 5 for node STAT3_Y705 and MAPK14\n", + "looking for paths in the network with length: 6 for node STAT3_Y705 and MAPK14\n", + "looking for paths in the network with length: 7 for node STAT3_Y705 and MAPK14\n", + "looking for paths in the network with length: 8 for node STAT3_Y705 and MAPK14\n", + "looking for paths in the network with length: 9 for node STAT3_Y705 and MAPK14\n", + "looking for paths in the network with length: 10 for node STAT3_Y705 and MAPK14\n", + "i_search = 4\n", + "Looking for paths with length: 0 for node STAT3_Y705 and MAPK14\n", + "i_search = 4\n", + "Looking for paths with length: 1 for node STAT3_Y705 and MAPK14\n", + "i_search = 4\n", + "Looking for paths with length: 2 for node STAT3_Y705 and MAPK14\n", + "i_search = 4\n", + "Looking for paths with length: 3 for node STAT3_Y705 and MAPK14\n", + "i_search = 4\n", + "Looking for paths with length: 4 for node STAT3_Y705 and MAPK14\n", + "looking for paths in the network with length: 0 for node STAT3_Y705 and MAP2K1\n", + "looking for paths in the network with length: 1 for node STAT3_Y705 and MAP2K1\n", + "looking for paths in the network with length: 2 for node STAT3_Y705 and MAP2K1\n", + "looking for paths in the network with length: 3 for node STAT3_Y705 and MAP2K1\n", + "looking for paths in the network with length: 4 for node STAT3_Y705 and MAP2K1\n", + "looking for paths in the network with length: 5 for node STAT3_Y705 and MAP2K1\n", + "looking for paths in the network with length: 6 for node STAT3_Y705 and MAP2K1\n", + "looking for paths in the network with length: 7 for node STAT3_Y705 and MAP2K1\n", + "looking for paths in the network with length: 8 for node STAT3_Y705 and MAP2K1\n", + "looking for paths in the network with length: 9 for node STAT3_Y705 and MAP2K1\n", + "looking for paths in the network with length: 10 for node STAT3_Y705 and MAP2K1\n", + "i_search = 4\n", + "Looking for paths with length: 0 for node STAT3_Y705 and MAP2K1\n", + "i_search = 4\n", + "Looking for paths with length: 1 for node STAT3_Y705 and MAP2K1\n", + "i_search = 4\n", + "Looking for paths with length: 2 for node STAT3_Y705 and MAP2K1\n", + "i_search = 4\n", + "Looking for paths with length: 3 for node STAT3_Y705 and MAP2K1\n", + "i_search = 4\n", + "Looking for paths with length: 4 for node STAT3_Y705 and MAP2K1\n", + "looking for paths in the network with length: 0 for node STAT3_Y705 and RPS6KA1\n", + "looking for paths in the network with length: 1 for node STAT3_Y705 and RPS6KA1\n", + "looking for paths in the network with length: 2 for node STAT3_Y705 and RPS6KA1\n", + "looking for paths in the network with length: 3 for node STAT3_Y705 and RPS6KA1\n", + "looking for paths in the network with length: 4 for node STAT3_Y705 and RPS6KA1\n", + "looking for paths in the network with length: 5 for node STAT3_Y705 and RPS6KA1\n", + "looking for paths in the network with length: 6 for node STAT3_Y705 and RPS6KA1\n", + "looking for paths in the network with length: 7 for node STAT3_Y705 and RPS6KA1\n", + "looking for paths in the network with length: 8 for node STAT3_Y705 and RPS6KA1\n", + "looking for paths in the network with length: 9 for node STAT3_Y705 and RPS6KA1\n", + "looking for paths in the network with length: 10 for node STAT3_Y705 and RPS6KA1\n", + "i_search = 4\n", + "Looking for paths with length: 0 for node STAT3_Y705 and RPS6KA1\n", + "i_search = 4\n", + "Looking for paths with length: 1 for node STAT3_Y705 and RPS6KA1\n", + "i_search = 4\n", + "Looking for paths with length: 2 for node STAT3_Y705 and RPS6KA1\n", + "i_search = 4\n", + "Looking for paths with length: 3 for node STAT3_Y705 and RPS6KA1\n", + "i_search = 4\n", + "Looking for paths with length: 4 for node STAT3_Y705 and RPS6KA1\n", + "looking for paths in the network with length: 0 for node STAT3_Y705 and CREB1\n", + "looking for paths in the network with length: 1 for node STAT3_Y705 and CREB1\n", + "looking for paths in the network with length: 2 for node STAT3_Y705 and CREB1\n", + "looking for paths in the network with length: 3 for node STAT3_Y705 and CREB1\n", + "looking for paths in the network with length: 4 for node STAT3_Y705 and CREB1\n", + "looking for paths in the network with length: 5 for node STAT3_Y705 and CREB1\n", + "looking for paths in the network with length: 6 for node STAT3_Y705 and CREB1\n", + "looking for paths in the network with length: 7 for node STAT3_Y705 and CREB1\n", + "looking for paths in the network with length: 8 for node STAT3_Y705 and CREB1\n", + "looking for paths in the network with length: 9 for node STAT3_Y705 and CREB1\n", + "looking for paths in the network with length: 10 for node STAT3_Y705 and CREB1\n", + "i_search = 4\n", + "Looking for paths with length: 0 for node STAT3_Y705 and CREB1\n", + "i_search = 4\n", + "Looking for paths with length: 1 for node STAT3_Y705 and CREB1\n", + "i_search = 4\n", + "Looking for paths with length: 2 for node STAT3_Y705 and CREB1\n", + "i_search = 4\n", + "Looking for paths with length: 3 for node STAT3_Y705 and CREB1\n", + "i_search = 4\n", + "Looking for paths with length: 4 for node STAT3_Y705 and CREB1\n", + "looking for paths in the network with length: 0 for node STAT3_Y705 and NFKBIA\n", + "looking for paths in the network with length: 1 for node STAT3_Y705 and NFKBIA\n", + "looking for paths in the network with length: 2 for node STAT3_Y705 and NFKBIA\n", + "looking for paths in the network with length: 3 for node STAT3_Y705 and NFKBIA\n", + "looking for paths in the network with length: 4 for node STAT3_Y705 and NFKBIA\n", + "looking for paths in the network with length: 5 for node STAT3_Y705 and NFKBIA\n", + "looking for paths in the network with length: 6 for node STAT3_Y705 and NFKBIA\n", + "looking for paths in the network with length: 7 for node STAT3_Y705 and NFKBIA\n", + "looking for paths in the network with length: 8 for node STAT3_Y705 and NFKBIA\n", + "looking for paths in the network with length: 9 for node STAT3_Y705 and NFKBIA\n", + "looking for paths in the network with length: 10 for node STAT3_Y705 and NFKBIA\n", + "i_search = 4\n", + "Looking for paths with length: 0 for node STAT3_Y705 and NFKBIA\n", + "i_search = 4\n", + "Looking for paths with length: 1 for node STAT3_Y705 and NFKBIA\n", + "i_search = 4\n", + "Looking for paths with length: 2 for node STAT3_Y705 and NFKBIA\n", + "i_search = 4\n", + "Looking for paths with length: 3 for node STAT3_Y705 and NFKBIA\n", + "i_search = 4\n", + "Looking for paths with length: 4 for node STAT3_Y705 and NFKBIA\n", + "looking for paths in the network with length: 0 for node STAT3_Y705 and MTOR\n", + "looking for paths in the network with length: 1 for node STAT3_Y705 and MTOR\n", + "looking for paths in the network with length: 2 for node STAT3_Y705 and MTOR\n", + "looking for paths in the network with length: 3 for node STAT3_Y705 and MTOR\n", + "looking for paths in the network with length: 4 for node STAT3_Y705 and MTOR\n", + "looking for paths in the network with length: 5 for node STAT3_Y705 and MTOR\n", + "looking for paths in the network with length: 6 for node STAT3_Y705 and MTOR\n", + "looking for paths in the network with length: 7 for node STAT3_Y705 and MTOR\n", + "looking for paths in the network with length: 8 for node STAT3_Y705 and MTOR\n", + "looking for paths in the network with length: 9 for node STAT3_Y705 and MTOR\n", + "looking for paths in the network with length: 10 for node STAT3_Y705 and MTOR\n", + "i_search = 4\n", + "Looking for paths with length: 0 for node STAT3_Y705 and MTOR\n", + "i_search = 4\n", + "Looking for paths with length: 1 for node STAT3_Y705 and MTOR\n", + "i_search = 4\n", + "Looking for paths with length: 2 for node STAT3_Y705 and MTOR\n", + "i_search = 4\n", + "Looking for paths with length: 3 for node STAT3_Y705 and MTOR\n", + "i_search = 4\n", + "Looking for paths with length: 4 for node STAT3_Y705 and MTOR\n", + "looking for paths in the network with length: 0 for node STAT3_Y705 and JUN\n", + "looking for paths in the network with length: 1 for node STAT3_Y705 and JUN\n", + "looking for paths in the network with length: 2 for node STAT3_Y705 and JUN\n", + "looking for paths in the network with length: 3 for node STAT3_Y705 and JUN\n", + "looking for paths in the network with length: 4 for node STAT3_Y705 and JUN\n", + "looking for paths in the network with length: 5 for node STAT3_Y705 and JUN\n", + "looking for paths in the network with length: 6 for node STAT3_Y705 and JUN\n", + "looking for paths in the network with length: 7 for node STAT3_Y705 and JUN\n", + "looking for paths in the network with length: 8 for node STAT3_Y705 and JUN\n", + "looking for paths in the network with length: 9 for node STAT3_Y705 and JUN\n", + "looking for paths in the network with length: 10 for node STAT3_Y705 and JUN\n", + "i_search = 4\n", + "Looking for paths with length: 0 for node STAT3_Y705 and JUN\n", + "i_search = 4\n", + "Looking for paths with length: 1 for node STAT3_Y705 and JUN\n", + "i_search = 4\n", + "Looking for paths with length: 2 for node STAT3_Y705 and JUN\n", + "i_search = 4\n", + "Looking for paths with length: 3 for node STAT3_Y705 and JUN\n", + "i_search = 4\n", + "Looking for paths with length: 4 for node STAT3_Y705 and JUN\n", + "looking for paths in the network with length: 0 for node STAT3_Y705 and EGFR\n", + "looking for paths in the network with length: 1 for node STAT3_Y705 and EGFR\n", + "looking for paths in the network with length: 2 for node STAT3_Y705 and EGFR\n", + "looking for paths in the network with length: 3 for node STAT3_Y705 and EGFR\n", + "looking for paths in the network with length: 4 for node STAT3_Y705 and EGFR\n", + "looking for paths in the network with length: 5 for node STAT3_Y705 and EGFR\n", + "looking for paths in the network with length: 6 for node STAT3_Y705 and EGFR\n", + "looking for paths in the network with length: 7 for node STAT3_Y705 and EGFR\n", + "looking for paths in the network with length: 8 for node STAT3_Y705 and EGFR\n", + "looking for paths in the network with length: 9 for node STAT3_Y705 and EGFR\n", + "looking for paths in the network with length: 10 for node STAT3_Y705 and EGFR\n", + "i_search = 4\n", + "Looking for paths with length: 0 for node STAT3_Y705 and EGFR\n", + "i_search = 4\n", + "Looking for paths with length: 1 for node STAT3_Y705 and EGFR\n", + "i_search = 4\n", + "Looking for paths with length: 2 for node STAT3_Y705 and EGFR\n", + "i_search = 4\n", + "Looking for paths with length: 3 for node STAT3_Y705 and EGFR\n", + "i_search = 4\n", + "Looking for paths with length: 4 for node STAT3_Y705 and EGFR\n", + "looking for paths in the network with length: 0 for node STAT3_Y705 and MAPK3\n", + "looking for paths in the network with length: 1 for node STAT3_Y705 and MAPK3\n", + "looking for paths in the network with length: 2 for node STAT3_Y705 and MAPK3\n", + "looking for paths in the network with length: 3 for node STAT3_Y705 and MAPK3\n", + "looking for paths in the network with length: 4 for node STAT3_Y705 and MAPK3\n", + "looking for paths in the network with length: 5 for node STAT3_Y705 and MAPK3\n", + "looking for paths in the network with length: 6 for node STAT3_Y705 and MAPK3\n", + "looking for paths in the network with length: 7 for node STAT3_Y705 and MAPK3\n", + "looking for paths in the network with length: 8 for node STAT3_Y705 and MAPK3\n", + "looking for paths in the network with length: 9 for node STAT3_Y705 and MAPK3\n", + "looking for paths in the network with length: 10 for node STAT3_Y705 and MAPK3\n", + "i_search = 4\n", + "Looking for paths with length: 0 for node STAT3_Y705 and MAPK3\n", + "i_search = 4\n", + "Looking for paths with length: 1 for node STAT3_Y705 and MAPK3\n", + "i_search = 4\n", + "Looking for paths with length: 2 for node STAT3_Y705 and MAPK3\n", + "i_search = 4\n", + "Looking for paths with length: 3 for node STAT3_Y705 and MAPK3\n", + "i_search = 4\n", + "Looking for paths with length: 4 for node STAT3_Y705 and MAPK3\n", + "looking for paths in the network with length: 0 for node STAT3_Y705 and PTPN11\n", + "looking for paths in the network with length: 1 for node STAT3_Y705 and PTPN11\n", + "looking for paths in the network with length: 2 for node STAT3_Y705 and PTPN11\n", + "looking for paths in the network with length: 3 for node STAT3_Y705 and PTPN11\n", + "looking for paths in the network with length: 4 for node STAT3_Y705 and PTPN11\n", + "looking for paths in the network with length: 5 for node STAT3_Y705 and PTPN11\n", + "looking for paths in the network with length: 6 for node STAT3_Y705 and PTPN11\n", + "looking for paths in the network with length: 7 for node STAT3_Y705 and PTPN11\n", + "looking for paths in the network with length: 8 for node STAT3_Y705 and PTPN11\n", + "looking for paths in the network with length: 9 for node STAT3_Y705 and PTPN11\n", + "looking for paths in the network with length: 10 for node STAT3_Y705 and PTPN11\n", + "i_search = 4\n", + "Looking for paths with length: 0 for node STAT3_Y705 and PTPN11\n", + "i_search = 4\n", + "Looking for paths with length: 1 for node STAT3_Y705 and PTPN11\n", + "i_search = 4\n", + "Looking for paths with length: 2 for node STAT3_Y705 and PTPN11\n", + "i_search = 4\n", + "Looking for paths with length: 3 for node STAT3_Y705 and PTPN11\n", + "i_search = 4\n", + "Looking for paths with length: 4 for node STAT3_Y705 and PTPN11\n", + "looking for paths in the network with length: 0 for node STAT3_Y705 and STAT3\n", + "looking for paths in the network with length: 1 for node STAT3_Y705 and STAT3\n", + "looking for paths in the network with length: 2 for node STAT3_Y705 and STAT3\n", + "looking for paths in the network with length: 3 for node STAT3_Y705 and STAT3\n", + "looking for paths in the network with length: 4 for node STAT3_Y705 and STAT3\n", + "looking for paths in the network with length: 5 for node STAT3_Y705 and STAT3\n", + "looking for paths in the network with length: 6 for node STAT3_Y705 and STAT3\n", + "looking for paths in the network with length: 7 for node STAT3_Y705 and STAT3\n", + "looking for paths in the network with length: 8 for node STAT3_Y705 and STAT3\n", + "looking for paths in the network with length: 9 for node STAT3_Y705 and STAT3\n", + "looking for paths in the network with length: 10 for node STAT3_Y705 and STAT3\n", + "i_search = 4\n", + "Looking for paths with length: 0 for node STAT3_Y705 and STAT3\n", + "i_search = 4\n", + "Looking for paths with length: 1 for node STAT3_Y705 and STAT3\n", + "i_search = 4\n", + "Looking for paths with length: 2 for node STAT3_Y705 and STAT3\n", + "i_search = 4\n", + "Looking for paths with length: 3 for node STAT3_Y705 and STAT3\n", + "i_search = 4\n", + "Looking for paths with length: 4 for node STAT3_Y705 and STAT3\n", + "looking for paths in the network with length: 0 for node STAT3_Y705 and CHEK2\n", + "looking for paths in the network with length: 1 for node STAT3_Y705 and CHEK2\n", + "looking for paths in the network with length: 2 for node STAT3_Y705 and CHEK2\n", + "looking for paths in the network with length: 3 for node STAT3_Y705 and CHEK2\n", + "looking for paths in the network with length: 4 for node STAT3_Y705 and CHEK2\n", + "looking for paths in the network with length: 5 for node STAT3_Y705 and CHEK2\n", + "looking for paths in the network with length: 6 for node STAT3_Y705 and CHEK2\n", + "looking for paths in the network with length: 7 for node STAT3_Y705 and CHEK2\n", + "looking for paths in the network with length: 8 for node STAT3_Y705 and CHEK2\n", + "looking for paths in the network with length: 9 for node STAT3_Y705 and CHEK2\n", + "looking for paths in the network with length: 10 for node STAT3_Y705 and CHEK2\n", + "i_search = 4\n", + "Looking for paths with length: 0 for node STAT3_Y705 and CHEK2\n", + "i_search = 4\n", + "Looking for paths with length: 1 for node STAT3_Y705 and CHEK2\n", + "i_search = 4\n", + "Looking for paths with length: 2 for node STAT3_Y705 and CHEK2\n", + "i_search = 4\n", + "Looking for paths with length: 3 for node STAT3_Y705 and CHEK2\n", + "i_search = 4\n", + "Looking for paths with length: 4 for node STAT3_Y705 and CHEK2\n", + "looking for paths in the network with length: 0 for node STAT3_Y705 and RELA\n", + "looking for paths in the network with length: 1 for node STAT3_Y705 and RELA\n", + "looking for paths in the network with length: 2 for node STAT3_Y705 and RELA\n", + "looking for paths in the network with length: 3 for node STAT3_Y705 and RELA\n", + "looking for paths in the network with length: 4 for node STAT3_Y705 and RELA\n", + "looking for paths in the network with length: 5 for node STAT3_Y705 and RELA\n", + "looking for paths in the network with length: 6 for node STAT3_Y705 and RELA\n", + "looking for paths in the network with length: 7 for node STAT3_Y705 and RELA\n", + "looking for paths in the network with length: 8 for node STAT3_Y705 and RELA\n", + "looking for paths in the network with length: 9 for node STAT3_Y705 and RELA\n", + "looking for paths in the network with length: 10 for node STAT3_Y705 and RELA\n", + "i_search = 4\n", + "Looking for paths with length: 0 for node STAT3_Y705 and RELA\n", + "i_search = 4\n", + "Looking for paths with length: 1 for node STAT3_Y705 and RELA\n", + "i_search = 4\n", + "Looking for paths with length: 2 for node STAT3_Y705 and RELA\n", + "i_search = 4\n", + "Looking for paths with length: 3 for node STAT3_Y705 and RELA\n", + "i_search = 4\n", + "Looking for paths with length: 4 for node STAT3_Y705 and RELA\n", + "looking for paths in the network with length: 0 for node STAT3_Y705 and MARCKS\n", + "looking for paths in the network with length: 1 for node STAT3_Y705 and MARCKS\n", + "looking for paths in the network with length: 2 for node STAT3_Y705 and MARCKS\n", + "looking for paths in the network with length: 3 for node STAT3_Y705 and MARCKS\n", + "looking for paths in the network with length: 4 for node STAT3_Y705 and MARCKS\n", + "looking for paths in the network with length: 5 for node STAT3_Y705 and MARCKS\n", + "looking for paths in the network with length: 6 for node STAT3_Y705 and MARCKS\n", + "looking for paths in the network with length: 7 for node STAT3_Y705 and MARCKS\n", + "looking for paths in the network with length: 8 for node STAT3_Y705 and MARCKS\n", + "looking for paths in the network with length: 9 for node STAT3_Y705 and MARCKS\n", + "looking for paths in the network with length: 10 for node STAT3_Y705 and MARCKS\n", + "i_search = 4\n", + "Looking for paths with length: 0 for node STAT3_Y705 and MARCKS\n", + "i_search = 4\n", + "Looking for paths with length: 1 for node STAT3_Y705 and MARCKS\n", + "i_search = 4\n", + "Looking for paths with length: 2 for node STAT3_Y705 and MARCKS\n", + "i_search = 4\n", + "Looking for paths with length: 3 for node STAT3_Y705 and MARCKS\n", + "i_search = 4\n", + "Looking for paths with length: 4 for node STAT3_Y705 and MARCKS\n", + "looking for paths in the network with length: 0 for node CHEK2_T68 and RELA_S536\n", + "looking for paths in the network with length: 1 for node CHEK2_T68 and RELA_S536\n", + "looking for paths in the network with length: 2 for node CHEK2_T68 and RELA_S536\n", + "looking for paths in the network with length: 3 for node CHEK2_T68 and RELA_S536\n", + "looking for paths in the network with length: 4 for node CHEK2_T68 and RELA_S536\n", + "looking for paths in the network with length: 5 for node CHEK2_T68 and RELA_S536\n", + "looking for paths in the network with length: 6 for node CHEK2_T68 and RELA_S536\n", + "looking for paths in the network with length: 7 for node CHEK2_T68 and RELA_S536\n", + "looking for paths in the network with length: 8 for node CHEK2_T68 and RELA_S536\n", + "looking for paths in the network with length: 9 for node CHEK2_T68 and RELA_S536\n", + "looking for paths in the network with length: 10 for node CHEK2_T68 and RELA_S536\n", + "i_search = 4\n", + "Looking for paths with length: 0 for node CHEK2_T68 and RELA_S536\n", + "i_search = 4\n", + "Looking for paths with length: 1 for node CHEK2_T68 and RELA_S536\n", + "i_search = 4\n", + "Looking for paths with length: 2 for node CHEK2_T68 and RELA_S536\n", + "i_search = 4\n", + "Looking for paths with length: 3 for node CHEK2_T68 and RELA_S536\n", + "i_search = 4\n", + "Looking for paths with length: 4 for node CHEK2_T68 and RELA_S536\n", + "looking for paths in the network with length: 0 for node CHEK2_T68 and MARCKS_S170\n", + "looking for paths in the network with length: 1 for node CHEK2_T68 and MARCKS_S170\n", + "looking for paths in the network with length: 2 for node CHEK2_T68 and MARCKS_S170\n", + "looking for paths in the network with length: 3 for node CHEK2_T68 and MARCKS_S170\n", + "looking for paths in the network with length: 4 for node CHEK2_T68 and MARCKS_S170\n", + "looking for paths in the network with length: 5 for node CHEK2_T68 and MARCKS_S170\n", + "looking for paths in the network with length: 6 for node CHEK2_T68 and MARCKS_S170\n", + "looking for paths in the network with length: 7 for node CHEK2_T68 and MARCKS_S170\n", + "looking for paths in the network with length: 8 for node CHEK2_T68 and MARCKS_S170\n", + "looking for paths in the network with length: 9 for node CHEK2_T68 and MARCKS_S170\n", + "looking for paths in the network with length: 10 for node CHEK2_T68 and MARCKS_S170\n", + "i_search = 4\n", + "Looking for paths with length: 0 for node CHEK2_T68 and MARCKS_S170\n", + "i_search = 4\n", + "Looking for paths with length: 1 for node CHEK2_T68 and MARCKS_S170\n", + "i_search = 4\n", + "Looking for paths with length: 2 for node CHEK2_T68 and MARCKS_S170\n", + "i_search = 4\n", + "Looking for paths with length: 3 for node CHEK2_T68 and MARCKS_S170\n", + "i_search = 4\n", + "Looking for paths with length: 4 for node CHEK2_T68 and MARCKS_S170\n", + "looking for paths in the network with length: 0 for node CHEK2_T68 and SMAD3\n", + "looking for paths in the network with length: 1 for node CHEK2_T68 and SMAD3\n", + "looking for paths in the network with length: 2 for node CHEK2_T68 and SMAD3\n", + "looking for paths in the network with length: 3 for node CHEK2_T68 and SMAD3\n", + "looking for paths in the network with length: 4 for node CHEK2_T68 and SMAD3\n", + "looking for paths in the network with length: 5 for node CHEK2_T68 and SMAD3\n", + "looking for paths in the network with length: 6 for node CHEK2_T68 and SMAD3\n", + "looking for paths in the network with length: 7 for node CHEK2_T68 and SMAD3\n", + "looking for paths in the network with length: 8 for node CHEK2_T68 and SMAD3\n", + "looking for paths in the network with length: 9 for node CHEK2_T68 and SMAD3\n", + "looking for paths in the network with length: 10 for node CHEK2_T68 and SMAD3\n", + "i_search = 4\n", + "Looking for paths with length: 0 for node CHEK2_T68 and SMAD3\n", + "i_search = 4\n", + "Looking for paths with length: 1 for node CHEK2_T68 and SMAD3\n", + "i_search = 4\n", + "Looking for paths with length: 2 for node CHEK2_T68 and SMAD3\n", + "i_search = 4\n", + "Looking for paths with length: 3 for node CHEK2_T68 and SMAD3\n", + "i_search = 4\n", + "Looking for paths with length: 4 for node CHEK2_T68 and SMAD3\n", + "looking for paths in the network with length: 0 for node CHEK2_T68 and TP53\n", + "looking for paths in the network with length: 1 for node CHEK2_T68 and TP53\n", + "looking for paths in the network with length: 2 for node CHEK2_T68 and TP53\n", + "looking for paths in the network with length: 3 for node CHEK2_T68 and TP53\n", + "looking for paths in the network with length: 4 for node CHEK2_T68 and TP53\n", + "looking for paths in the network with length: 5 for node CHEK2_T68 and TP53\n", + "looking for paths in the network with length: 6 for node CHEK2_T68 and TP53\n", + "looking for paths in the network with length: 7 for node CHEK2_T68 and TP53\n", + "looking for paths in the network with length: 8 for node CHEK2_T68 and TP53\n", + "looking for paths in the network with length: 9 for node CHEK2_T68 and TP53\n", + "looking for paths in the network with length: 10 for node CHEK2_T68 and TP53\n", + "i_search = 4\n", + "Looking for paths with length: 0 for node CHEK2_T68 and TP53\n", + "i_search = 4\n", + "Looking for paths with length: 1 for node CHEK2_T68 and TP53\n", + "i_search = 4\n", + "Looking for paths with length: 2 for node CHEK2_T68 and TP53\n", + "i_search = 4\n", + "Looking for paths with length: 3 for node CHEK2_T68 and TP53\n", + "i_search = 4\n", + "Looking for paths with length: 4 for node CHEK2_T68 and TP53\n", + "looking for paths in the network with length: 0 for node CHEK2_T68 and AKT1S1\n", + "looking for paths in the network with length: 1 for node CHEK2_T68 and AKT1S1\n", + "looking for paths in the network with length: 2 for node CHEK2_T68 and AKT1S1\n", + "looking for paths in the network with length: 3 for node CHEK2_T68 and AKT1S1\n", + "looking for paths in the network with length: 4 for node CHEK2_T68 and AKT1S1\n", + "looking for paths in the network with length: 5 for node CHEK2_T68 and AKT1S1\n", + "looking for paths in the network with length: 6 for node CHEK2_T68 and AKT1S1\n", + "looking for paths in the network with length: 7 for node CHEK2_T68 and AKT1S1\n", + "looking for paths in the network with length: 8 for node CHEK2_T68 and AKT1S1\n", + "looking for paths in the network with length: 9 for node CHEK2_T68 and AKT1S1\n", + "looking for paths in the network with length: 10 for node CHEK2_T68 and AKT1S1\n", + "i_search = 4\n", + "Looking for paths with length: 0 for node CHEK2_T68 and AKT1S1\n", + "i_search = 4\n", + "Looking for paths with length: 1 for node CHEK2_T68 and AKT1S1\n", + "i_search = 4\n", + "Looking for paths with length: 2 for node CHEK2_T68 and AKT1S1\n", + "i_search = 4\n", + "Looking for paths with length: 3 for node CHEK2_T68 and AKT1S1\n", + "i_search = 4\n", + "Looking for paths with length: 4 for node CHEK2_T68 and AKT1S1\n", + "looking for paths in the network with length: 0 for node CHEK2_T68 and GSK3B\n", + "looking for paths in the network with length: 1 for node CHEK2_T68 and GSK3B\n", + "looking for paths in the network with length: 2 for node CHEK2_T68 and GSK3B\n", + "looking for paths in the network with length: 3 for node CHEK2_T68 and GSK3B\n", + "looking for paths in the network with length: 4 for node CHEK2_T68 and GSK3B\n", + "looking for paths in the network with length: 5 for node CHEK2_T68 and GSK3B\n", + "looking for paths in the network with length: 6 for node CHEK2_T68 and GSK3B\n", + "looking for paths in the network with length: 7 for node CHEK2_T68 and GSK3B\n", + "looking for paths in the network with length: 8 for node CHEK2_T68 and GSK3B\n", + "looking for paths in the network with length: 9 for node CHEK2_T68 and GSK3B\n", + "looking for paths in the network with length: 10 for node CHEK2_T68 and GSK3B\n", + "i_search = 4\n", + "Looking for paths with length: 0 for node CHEK2_T68 and GSK3B\n", + "i_search = 4\n", + "Looking for paths with length: 1 for node CHEK2_T68 and GSK3B\n", + "i_search = 4\n", + "Looking for paths with length: 2 for node CHEK2_T68 and GSK3B\n", + "i_search = 4\n", + "Looking for paths with length: 3 for node CHEK2_T68 and GSK3B\n", + "i_search = 4\n", + "Looking for paths with length: 4 for node CHEK2_T68 and GSK3B\n", + "looking for paths in the network with length: 0 for node CHEK2_T68 and AKT1\n", + "looking for paths in the network with length: 1 for node CHEK2_T68 and AKT1\n", + "looking for paths in the network with length: 2 for node CHEK2_T68 and AKT1\n", + "looking for paths in the network with length: 3 for node CHEK2_T68 and AKT1\n", + "looking for paths in the network with length: 4 for node CHEK2_T68 and AKT1\n", + "looking for paths in the network with length: 5 for node CHEK2_T68 and AKT1\n", + "looking for paths in the network with length: 6 for node CHEK2_T68 and AKT1\n", + "looking for paths in the network with length: 7 for node CHEK2_T68 and AKT1\n", + "looking for paths in the network with length: 8 for node CHEK2_T68 and AKT1\n", + "looking for paths in the network with length: 9 for node CHEK2_T68 and AKT1\n", + "looking for paths in the network with length: 10 for node CHEK2_T68 and AKT1\n", + "i_search = 4\n", + "Looking for paths with length: 0 for node CHEK2_T68 and AKT1\n", + "i_search = 4\n", + "Looking for paths with length: 1 for node CHEK2_T68 and AKT1\n", + "i_search = 4\n", + "Looking for paths with length: 2 for node CHEK2_T68 and AKT1\n", + "i_search = 4\n", + "Looking for paths with length: 3 for node CHEK2_T68 and AKT1\n", + "i_search = 4\n", + "Looking for paths with length: 4 for node CHEK2_T68 and AKT1\n", + "looking for paths in the network with length: 0 for node CHEK2_T68 and HSPB1\n", + "looking for paths in the network with length: 1 for node CHEK2_T68 and HSPB1\n", + "looking for paths in the network with length: 2 for node CHEK2_T68 and HSPB1\n", + "looking for paths in the network with length: 3 for node CHEK2_T68 and HSPB1\n", + "looking for paths in the network with length: 4 for node CHEK2_T68 and HSPB1\n", + "looking for paths in the network with length: 5 for node CHEK2_T68 and HSPB1\n", + "looking for paths in the network with length: 6 for node CHEK2_T68 and HSPB1\n", + "looking for paths in the network with length: 7 for node CHEK2_T68 and HSPB1\n", + "looking for paths in the network with length: 8 for node CHEK2_T68 and HSPB1\n", + "looking for paths in the network with length: 9 for node CHEK2_T68 and HSPB1\n", + "looking for paths in the network with length: 10 for node CHEK2_T68 and HSPB1\n", + "i_search = 4\n", + "Looking for paths with length: 0 for node CHEK2_T68 and HSPB1\n", + "i_search = 4\n", + "Looking for paths with length: 1 for node CHEK2_T68 and HSPB1\n", + "i_search = 4\n", + "Looking for paths with length: 2 for node CHEK2_T68 and HSPB1\n", + "i_search = 4\n", + "Looking for paths with length: 3 for node CHEK2_T68 and HSPB1\n", + "i_search = 4\n", + "Looking for paths with length: 4 for node CHEK2_T68 and HSPB1\n", + "looking for paths in the network with length: 0 for node CHEK2_T68 and MAPK14\n", + "looking for paths in the network with length: 1 for node CHEK2_T68 and MAPK14\n", + "looking for paths in the network with length: 2 for node CHEK2_T68 and MAPK14\n", + "looking for paths in the network with length: 3 for node CHEK2_T68 and MAPK14\n", + "looking for paths in the network with length: 4 for node CHEK2_T68 and MAPK14\n", + "looking for paths in the network with length: 5 for node CHEK2_T68 and MAPK14\n", + "looking for paths in the network with length: 6 for node CHEK2_T68 and MAPK14\n", + "looking for paths in the network with length: 7 for node CHEK2_T68 and MAPK14\n", + "looking for paths in the network with length: 8 for node CHEK2_T68 and MAPK14\n", + "looking for paths in the network with length: 9 for node CHEK2_T68 and MAPK14\n", + "looking for paths in the network with length: 10 for node CHEK2_T68 and MAPK14\n", + "i_search = 4\n", + "Looking for paths with length: 0 for node CHEK2_T68 and MAPK14\n", + "i_search = 4\n", + "Looking for paths with length: 1 for node CHEK2_T68 and MAPK14\n", + "i_search = 4\n", + "Looking for paths with length: 2 for node CHEK2_T68 and MAPK14\n", + "i_search = 4\n", + "Looking for paths with length: 3 for node CHEK2_T68 and MAPK14\n", + "i_search = 4\n", + "Looking for paths with length: 4 for node CHEK2_T68 and MAPK14\n", + "looking for paths in the network with length: 0 for node CHEK2_T68 and MAP2K1\n", + "looking for paths in the network with length: 1 for node CHEK2_T68 and MAP2K1\n", + "looking for paths in the network with length: 2 for node CHEK2_T68 and MAP2K1\n", + "looking for paths in the network with length: 3 for node CHEK2_T68 and MAP2K1\n", + "looking for paths in the network with length: 4 for node CHEK2_T68 and MAP2K1\n", + "looking for paths in the network with length: 5 for node CHEK2_T68 and MAP2K1\n", + "looking for paths in the network with length: 6 for node CHEK2_T68 and MAP2K1\n", + "looking for paths in the network with length: 7 for node CHEK2_T68 and MAP2K1\n", + "looking for paths in the network with length: 8 for node CHEK2_T68 and MAP2K1\n", + "looking for paths in the network with length: 9 for node CHEK2_T68 and MAP2K1\n", + "looking for paths in the network with length: 10 for node CHEK2_T68 and MAP2K1\n", + "i_search = 4\n", + "Looking for paths with length: 0 for node CHEK2_T68 and MAP2K1\n", + "i_search = 4\n", + "Looking for paths with length: 1 for node CHEK2_T68 and MAP2K1\n", + "i_search = 4\n", + "Looking for paths with length: 2 for node CHEK2_T68 and MAP2K1\n", + "i_search = 4\n", + "Looking for paths with length: 3 for node CHEK2_T68 and MAP2K1\n", + "i_search = 4\n", + "Looking for paths with length: 4 for node CHEK2_T68 and MAP2K1\n", + "looking for paths in the network with length: 0 for node CHEK2_T68 and RPS6KA1\n", + "looking for paths in the network with length: 1 for node CHEK2_T68 and RPS6KA1\n", + "looking for paths in the network with length: 2 for node CHEK2_T68 and RPS6KA1\n", + "looking for paths in the network with length: 3 for node CHEK2_T68 and RPS6KA1\n", + "looking for paths in the network with length: 4 for node CHEK2_T68 and RPS6KA1\n", + "looking for paths in the network with length: 5 for node CHEK2_T68 and RPS6KA1\n", + "looking for paths in the network with length: 6 for node CHEK2_T68 and RPS6KA1\n", + "looking for paths in the network with length: 7 for node CHEK2_T68 and RPS6KA1\n", + "looking for paths in the network with length: 8 for node CHEK2_T68 and RPS6KA1\n", + "looking for paths in the network with length: 9 for node CHEK2_T68 and RPS6KA1\n", + "looking for paths in the network with length: 10 for node CHEK2_T68 and RPS6KA1\n", + "i_search = 4\n", + "Looking for paths with length: 0 for node CHEK2_T68 and RPS6KA1\n", + "i_search = 4\n", + "Looking for paths with length: 1 for node CHEK2_T68 and RPS6KA1\n", + "i_search = 4\n", + "Looking for paths with length: 2 for node CHEK2_T68 and RPS6KA1\n", + "i_search = 4\n", + "Looking for paths with length: 3 for node CHEK2_T68 and RPS6KA1\n", + "i_search = 4\n", + "Looking for paths with length: 4 for node CHEK2_T68 and RPS6KA1\n", + "looking for paths in the network with length: 0 for node CHEK2_T68 and CREB1\n", + "looking for paths in the network with length: 1 for node CHEK2_T68 and CREB1\n", + "looking for paths in the network with length: 2 for node CHEK2_T68 and CREB1\n", + "looking for paths in the network with length: 3 for node CHEK2_T68 and CREB1\n", + "looking for paths in the network with length: 4 for node CHEK2_T68 and CREB1\n", + "looking for paths in the network with length: 5 for node CHEK2_T68 and CREB1\n", + "looking for paths in the network with length: 6 for node CHEK2_T68 and CREB1\n", + "looking for paths in the network with length: 7 for node CHEK2_T68 and CREB1\n", + "looking for paths in the network with length: 8 for node CHEK2_T68 and CREB1\n", + "looking for paths in the network with length: 9 for node CHEK2_T68 and CREB1\n", + "looking for paths in the network with length: 10 for node CHEK2_T68 and CREB1\n", + "i_search = 4\n", + "Looking for paths with length: 0 for node CHEK2_T68 and CREB1\n", + "i_search = 4\n", + "Looking for paths with length: 1 for node CHEK2_T68 and CREB1\n", + "i_search = 4\n", + "Looking for paths with length: 2 for node CHEK2_T68 and CREB1\n", + "i_search = 4\n", + "Looking for paths with length: 3 for node CHEK2_T68 and CREB1\n", + "i_search = 4\n", + "Looking for paths with length: 4 for node CHEK2_T68 and CREB1\n", + "looking for paths in the network with length: 0 for node CHEK2_T68 and NFKBIA\n", + "looking for paths in the network with length: 1 for node CHEK2_T68 and NFKBIA\n", + "looking for paths in the network with length: 2 for node CHEK2_T68 and NFKBIA\n", + "looking for paths in the network with length: 3 for node CHEK2_T68 and NFKBIA\n", + "looking for paths in the network with length: 4 for node CHEK2_T68 and NFKBIA\n", + "looking for paths in the network with length: 5 for node CHEK2_T68 and NFKBIA\n", + "looking for paths in the network with length: 6 for node CHEK2_T68 and NFKBIA\n", + "looking for paths in the network with length: 7 for node CHEK2_T68 and NFKBIA\n", + "looking for paths in the network with length: 8 for node CHEK2_T68 and NFKBIA\n", + "looking for paths in the network with length: 9 for node CHEK2_T68 and NFKBIA\n", + "looking for paths in the network with length: 10 for node CHEK2_T68 and NFKBIA\n", + "i_search = 4\n", + "Looking for paths with length: 0 for node CHEK2_T68 and NFKBIA\n", + "i_search = 4\n", + "Looking for paths with length: 1 for node CHEK2_T68 and NFKBIA\n", + "i_search = 4\n", + "Looking for paths with length: 2 for node CHEK2_T68 and NFKBIA\n", + "i_search = 4\n", + "Looking for paths with length: 3 for node CHEK2_T68 and NFKBIA\n", + "i_search = 4\n", + "Looking for paths with length: 4 for node CHEK2_T68 and NFKBIA\n", + "looking for paths in the network with length: 0 for node CHEK2_T68 and MTOR\n", + "looking for paths in the network with length: 1 for node CHEK2_T68 and MTOR\n", + "looking for paths in the network with length: 2 for node CHEK2_T68 and MTOR\n", + "looking for paths in the network with length: 3 for node CHEK2_T68 and MTOR\n", + "looking for paths in the network with length: 4 for node CHEK2_T68 and MTOR\n", + "looking for paths in the network with length: 5 for node CHEK2_T68 and MTOR\n", + "looking for paths in the network with length: 6 for node CHEK2_T68 and MTOR\n", + "looking for paths in the network with length: 7 for node CHEK2_T68 and MTOR\n", + "looking for paths in the network with length: 8 for node CHEK2_T68 and MTOR\n", + "looking for paths in the network with length: 9 for node CHEK2_T68 and MTOR\n", + "looking for paths in the network with length: 10 for node CHEK2_T68 and MTOR\n", + "i_search = 4\n", + "Looking for paths with length: 0 for node CHEK2_T68 and MTOR\n", + "i_search = 4\n", + "Looking for paths with length: 1 for node CHEK2_T68 and MTOR\n", + "i_search = 4\n", + "Looking for paths with length: 2 for node CHEK2_T68 and MTOR\n", + "i_search = 4\n", + "Looking for paths with length: 3 for node CHEK2_T68 and MTOR\n", + "i_search = 4\n", + "Looking for paths with length: 4 for node CHEK2_T68 and MTOR\n", + "looking for paths in the network with length: 0 for node CHEK2_T68 and JUN\n", + "looking for paths in the network with length: 1 for node CHEK2_T68 and JUN\n", + "looking for paths in the network with length: 2 for node CHEK2_T68 and JUN\n", + "looking for paths in the network with length: 3 for node CHEK2_T68 and JUN\n", + "looking for paths in the network with length: 4 for node CHEK2_T68 and JUN\n", + "looking for paths in the network with length: 5 for node CHEK2_T68 and JUN\n", + "looking for paths in the network with length: 6 for node CHEK2_T68 and JUN\n", + "looking for paths in the network with length: 7 for node CHEK2_T68 and JUN\n", + "looking for paths in the network with length: 8 for node CHEK2_T68 and JUN\n", + "looking for paths in the network with length: 9 for node CHEK2_T68 and JUN\n", + "looking for paths in the network with length: 10 for node CHEK2_T68 and JUN\n", + "i_search = 4\n", + "Looking for paths with length: 0 for node CHEK2_T68 and JUN\n", + "i_search = 4\n", + "Looking for paths with length: 1 for node CHEK2_T68 and JUN\n", + "i_search = 4\n", + "Looking for paths with length: 2 for node CHEK2_T68 and JUN\n", + "i_search = 4\n", + "Looking for paths with length: 3 for node CHEK2_T68 and JUN\n", + "i_search = 4\n", + "Looking for paths with length: 4 for node CHEK2_T68 and JUN\n", + "looking for paths in the network with length: 0 for node CHEK2_T68 and EGFR\n", + "looking for paths in the network with length: 1 for node CHEK2_T68 and EGFR\n", + "looking for paths in the network with length: 2 for node CHEK2_T68 and EGFR\n", + "looking for paths in the network with length: 3 for node CHEK2_T68 and EGFR\n", + "looking for paths in the network with length: 4 for node CHEK2_T68 and EGFR\n", + "looking for paths in the network with length: 5 for node CHEK2_T68 and EGFR\n", + "looking for paths in the network with length: 6 for node CHEK2_T68 and EGFR\n", + "looking for paths in the network with length: 7 for node CHEK2_T68 and EGFR\n", + "looking for paths in the network with length: 8 for node CHEK2_T68 and EGFR\n", + "looking for paths in the network with length: 9 for node CHEK2_T68 and EGFR\n", + "looking for paths in the network with length: 10 for node CHEK2_T68 and EGFR\n", + "i_search = 4\n", + "Looking for paths with length: 0 for node CHEK2_T68 and EGFR\n", + "i_search = 4\n", + "Looking for paths with length: 1 for node CHEK2_T68 and EGFR\n", + "i_search = 4\n", + "Looking for paths with length: 2 for node CHEK2_T68 and EGFR\n", + "i_search = 4\n", + "Looking for paths with length: 3 for node CHEK2_T68 and EGFR\n", + "i_search = 4\n", + "Looking for paths with length: 4 for node CHEK2_T68 and EGFR\n", + "looking for paths in the network with length: 0 for node CHEK2_T68 and MAPK3\n", + "looking for paths in the network with length: 1 for node CHEK2_T68 and MAPK3\n", + "looking for paths in the network with length: 2 for node CHEK2_T68 and MAPK3\n", + "looking for paths in the network with length: 3 for node CHEK2_T68 and MAPK3\n", + "looking for paths in the network with length: 4 for node CHEK2_T68 and MAPK3\n", + "looking for paths in the network with length: 5 for node CHEK2_T68 and MAPK3\n", + "looking for paths in the network with length: 6 for node CHEK2_T68 and MAPK3\n", + "looking for paths in the network with length: 7 for node CHEK2_T68 and MAPK3\n", + "looking for paths in the network with length: 8 for node CHEK2_T68 and MAPK3\n", + "looking for paths in the network with length: 9 for node CHEK2_T68 and MAPK3\n", + "looking for paths in the network with length: 10 for node CHEK2_T68 and MAPK3\n", + "i_search = 4\n", + "Looking for paths with length: 0 for node CHEK2_T68 and MAPK3\n", + "i_search = 4\n", + "Looking for paths with length: 1 for node CHEK2_T68 and MAPK3\n", + "i_search = 4\n", + "Looking for paths with length: 2 for node CHEK2_T68 and MAPK3\n", + "i_search = 4\n", + "Looking for paths with length: 3 for node CHEK2_T68 and MAPK3\n", + "i_search = 4\n", + "Looking for paths with length: 4 for node CHEK2_T68 and MAPK3\n", + "looking for paths in the network with length: 0 for node CHEK2_T68 and PTPN11\n", + "looking for paths in the network with length: 1 for node CHEK2_T68 and PTPN11\n", + "looking for paths in the network with length: 2 for node CHEK2_T68 and PTPN11\n", + "looking for paths in the network with length: 3 for node CHEK2_T68 and PTPN11\n", + "looking for paths in the network with length: 4 for node CHEK2_T68 and PTPN11\n", + "looking for paths in the network with length: 5 for node CHEK2_T68 and PTPN11\n", + "looking for paths in the network with length: 6 for node CHEK2_T68 and PTPN11\n", + "looking for paths in the network with length: 7 for node CHEK2_T68 and PTPN11\n", + "looking for paths in the network with length: 8 for node CHEK2_T68 and PTPN11\n", + "looking for paths in the network with length: 9 for node CHEK2_T68 and PTPN11\n", + "looking for paths in the network with length: 10 for node CHEK2_T68 and PTPN11\n", + "i_search = 4\n", + "Looking for paths with length: 0 for node CHEK2_T68 and PTPN11\n", + "i_search = 4\n", + "Looking for paths with length: 1 for node CHEK2_T68 and PTPN11\n", + "i_search = 4\n", + "Looking for paths with length: 2 for node CHEK2_T68 and PTPN11\n", + "i_search = 4\n", + "Looking for paths with length: 3 for node CHEK2_T68 and PTPN11\n", + "i_search = 4\n", + "Looking for paths with length: 4 for node CHEK2_T68 and PTPN11\n", + "looking for paths in the network with length: 0 for node CHEK2_T68 and STAT3\n", + "looking for paths in the network with length: 1 for node CHEK2_T68 and STAT3\n", + "looking for paths in the network with length: 2 for node CHEK2_T68 and STAT3\n", + "looking for paths in the network with length: 3 for node CHEK2_T68 and STAT3\n", + "looking for paths in the network with length: 4 for node CHEK2_T68 and STAT3\n", + "looking for paths in the network with length: 5 for node CHEK2_T68 and STAT3\n", + "looking for paths in the network with length: 6 for node CHEK2_T68 and STAT3\n", + "looking for paths in the network with length: 7 for node CHEK2_T68 and STAT3\n", + "looking for paths in the network with length: 8 for node CHEK2_T68 and STAT3\n", + "looking for paths in the network with length: 9 for node CHEK2_T68 and STAT3\n", + "looking for paths in the network with length: 10 for node CHEK2_T68 and STAT3\n", + "i_search = 4\n", + "Looking for paths with length: 0 for node CHEK2_T68 and STAT3\n", + "i_search = 4\n", + "Looking for paths with length: 1 for node CHEK2_T68 and STAT3\n", + "i_search = 4\n", + "Looking for paths with length: 2 for node CHEK2_T68 and STAT3\n", + "i_search = 4\n", + "Looking for paths with length: 3 for node CHEK2_T68 and STAT3\n", + "i_search = 4\n", + "Looking for paths with length: 4 for node CHEK2_T68 and STAT3\n", + "looking for paths in the network with length: 0 for node CHEK2_T68 and CHEK2\n", + "looking for paths in the network with length: 1 for node CHEK2_T68 and CHEK2\n", + "looking for paths in the network with length: 2 for node CHEK2_T68 and CHEK2\n", + "looking for paths in the network with length: 3 for node CHEK2_T68 and CHEK2\n", + "looking for paths in the network with length: 4 for node CHEK2_T68 and CHEK2\n", + "looking for paths in the network with length: 5 for node CHEK2_T68 and CHEK2\n", + "looking for paths in the network with length: 6 for node CHEK2_T68 and CHEK2\n", + "looking for paths in the network with length: 7 for node CHEK2_T68 and CHEK2\n", + "looking for paths in the network with length: 8 for node CHEK2_T68 and CHEK2\n", + "looking for paths in the network with length: 9 for node CHEK2_T68 and CHEK2\n", + "looking for paths in the network with length: 10 for node CHEK2_T68 and CHEK2\n", + "i_search = 4\n", + "Looking for paths with length: 0 for node CHEK2_T68 and CHEK2\n", + "i_search = 4\n", + "Looking for paths with length: 1 for node CHEK2_T68 and CHEK2\n", + "i_search = 4\n", + "Looking for paths with length: 2 for node CHEK2_T68 and CHEK2\n", + "i_search = 4\n", + "Looking for paths with length: 3 for node CHEK2_T68 and CHEK2\n", + "i_search = 4\n", + "Looking for paths with length: 4 for node CHEK2_T68 and CHEK2\n", + "looking for paths in the network with length: 0 for node CHEK2_T68 and RELA\n", + "looking for paths in the network with length: 1 for node CHEK2_T68 and RELA\n", + "looking for paths in the network with length: 2 for node CHEK2_T68 and RELA\n", + "looking for paths in the network with length: 3 for node CHEK2_T68 and RELA\n", + "looking for paths in the network with length: 4 for node CHEK2_T68 and RELA\n", + "looking for paths in the network with length: 5 for node CHEK2_T68 and RELA\n", + "looking for paths in the network with length: 6 for node CHEK2_T68 and RELA\n", + "looking for paths in the network with length: 7 for node CHEK2_T68 and RELA\n", + "looking for paths in the network with length: 8 for node CHEK2_T68 and RELA\n", + "looking for paths in the network with length: 9 for node CHEK2_T68 and RELA\n", + "looking for paths in the network with length: 10 for node CHEK2_T68 and RELA\n", + "i_search = 4\n", + "Looking for paths with length: 0 for node CHEK2_T68 and RELA\n", + "i_search = 4\n", + "Looking for paths with length: 1 for node CHEK2_T68 and RELA\n", + "i_search = 4\n", + "Looking for paths with length: 2 for node CHEK2_T68 and RELA\n", + "i_search = 4\n", + "Looking for paths with length: 3 for node CHEK2_T68 and RELA\n", + "i_search = 4\n", + "Looking for paths with length: 4 for node CHEK2_T68 and RELA\n", + "looking for paths in the network with length: 0 for node CHEK2_T68 and MARCKS\n", + "looking for paths in the network with length: 1 for node CHEK2_T68 and MARCKS\n", + "looking for paths in the network with length: 2 for node CHEK2_T68 and MARCKS\n", + "looking for paths in the network with length: 3 for node CHEK2_T68 and MARCKS\n", + "looking for paths in the network with length: 4 for node CHEK2_T68 and MARCKS\n", + "looking for paths in the network with length: 5 for node CHEK2_T68 and MARCKS\n", + "looking for paths in the network with length: 6 for node CHEK2_T68 and MARCKS\n", + "looking for paths in the network with length: 7 for node CHEK2_T68 and MARCKS\n", + "looking for paths in the network with length: 8 for node CHEK2_T68 and MARCKS\n", + "looking for paths in the network with length: 9 for node CHEK2_T68 and MARCKS\n", + "looking for paths in the network with length: 10 for node CHEK2_T68 and MARCKS\n", + "i_search = 4\n", + "Looking for paths with length: 0 for node CHEK2_T68 and MARCKS\n", + "i_search = 4\n", + "Looking for paths with length: 1 for node CHEK2_T68 and MARCKS\n", + "i_search = 4\n", + "Looking for paths with length: 2 for node CHEK2_T68 and MARCKS\n", + "i_search = 4\n", + "Looking for paths with length: 3 for node CHEK2_T68 and MARCKS\n", + "i_search = 4\n", + "Looking for paths with length: 4 for node CHEK2_T68 and MARCKS\n", + "looking for paths in the network with length: 0 for node RELA_S536 and MARCKS_S170\n", + "looking for paths in the network with length: 1 for node RELA_S536 and MARCKS_S170\n", + "looking for paths in the network with length: 2 for node RELA_S536 and MARCKS_S170\n", + "looking for paths in the network with length: 3 for node RELA_S536 and MARCKS_S170\n", + "looking for paths in the network with length: 4 for node RELA_S536 and MARCKS_S170\n", + "looking for paths in the network with length: 5 for node RELA_S536 and MARCKS_S170\n", + "looking for paths in the network with length: 6 for node RELA_S536 and MARCKS_S170\n", + "looking for paths in the network with length: 7 for node RELA_S536 and MARCKS_S170\n", + "looking for paths in the network with length: 8 for node RELA_S536 and MARCKS_S170\n", + "looking for paths in the network with length: 9 for node RELA_S536 and MARCKS_S170\n", + "looking for paths in the network with length: 10 for node RELA_S536 and MARCKS_S170\n", + "i_search = 4\n", + "Looking for paths with length: 0 for node RELA_S536 and MARCKS_S170\n", + "i_search = 4\n", + "Looking for paths with length: 1 for node RELA_S536 and MARCKS_S170\n", + "i_search = 4\n", + "Looking for paths with length: 2 for node RELA_S536 and MARCKS_S170\n", + "i_search = 4\n", + "Looking for paths with length: 3 for node RELA_S536 and MARCKS_S170\n", + "i_search = 4\n", + "Looking for paths with length: 4 for node RELA_S536 and MARCKS_S170\n", + "looking for paths in the network with length: 0 for node RELA_S536 and SMAD3\n", + "looking for paths in the network with length: 1 for node RELA_S536 and SMAD3\n", + "looking for paths in the network with length: 2 for node RELA_S536 and SMAD3\n", + "looking for paths in the network with length: 3 for node RELA_S536 and SMAD3\n", + "looking for paths in the network with length: 4 for node RELA_S536 and SMAD3\n", + "looking for paths in the network with length: 5 for node RELA_S536 and SMAD3\n", + "looking for paths in the network with length: 6 for node RELA_S536 and SMAD3\n", + "looking for paths in the network with length: 7 for node RELA_S536 and SMAD3\n", + "looking for paths in the network with length: 8 for node RELA_S536 and SMAD3\n", + "looking for paths in the network with length: 9 for node RELA_S536 and SMAD3\n", + "looking for paths in the network with length: 10 for node RELA_S536 and SMAD3\n", + "i_search = 4\n", + "Looking for paths with length: 0 for node RELA_S536 and SMAD3\n", + "i_search = 4\n", + "Looking for paths with length: 1 for node RELA_S536 and SMAD3\n", + "i_search = 4\n", + "Looking for paths with length: 2 for node RELA_S536 and SMAD3\n", + "i_search = 4\n", + "Looking for paths with length: 3 for node RELA_S536 and SMAD3\n", + "i_search = 4\n", + "Looking for paths with length: 4 for node RELA_S536 and SMAD3\n", + "looking for paths in the network with length: 0 for node RELA_S536 and TP53\n", + "looking for paths in the network with length: 1 for node RELA_S536 and TP53\n", + "looking for paths in the network with length: 2 for node RELA_S536 and TP53\n", + "looking for paths in the network with length: 3 for node RELA_S536 and TP53\n", + "looking for paths in the network with length: 4 for node RELA_S536 and TP53\n", + "looking for paths in the network with length: 5 for node RELA_S536 and TP53\n", + "looking for paths in the network with length: 6 for node RELA_S536 and TP53\n", + "looking for paths in the network with length: 7 for node RELA_S536 and TP53\n", + "looking for paths in the network with length: 8 for node RELA_S536 and TP53\n", + "looking for paths in the network with length: 9 for node RELA_S536 and TP53\n", + "looking for paths in the network with length: 10 for node RELA_S536 and TP53\n", + "i_search = 4\n", + "Looking for paths with length: 0 for node RELA_S536 and TP53\n", + "i_search = 4\n", + "Looking for paths with length: 1 for node RELA_S536 and TP53\n", + "i_search = 4\n", + "Looking for paths with length: 2 for node RELA_S536 and TP53\n", + "i_search = 4\n", + "Looking for paths with length: 3 for node RELA_S536 and TP53\n", + "i_search = 4\n", + "Looking for paths with length: 4 for node RELA_S536 and TP53\n", + "looking for paths in the network with length: 0 for node RELA_S536 and AKT1S1\n", + "looking for paths in the network with length: 1 for node RELA_S536 and AKT1S1\n", + "looking for paths in the network with length: 2 for node RELA_S536 and AKT1S1\n", + "looking for paths in the network with length: 3 for node RELA_S536 and AKT1S1\n", + "looking for paths in the network with length: 4 for node RELA_S536 and AKT1S1\n", + "looking for paths in the network with length: 5 for node RELA_S536 and AKT1S1\n", + "looking for paths in the network with length: 6 for node RELA_S536 and AKT1S1\n", + "looking for paths in the network with length: 7 for node RELA_S536 and AKT1S1\n", + "looking for paths in the network with length: 8 for node RELA_S536 and AKT1S1\n", + "looking for paths in the network with length: 9 for node RELA_S536 and AKT1S1\n", + "looking for paths in the network with length: 10 for node RELA_S536 and AKT1S1\n", + "i_search = 4\n", + "Looking for paths with length: 0 for node RELA_S536 and AKT1S1\n", + "i_search = 4\n", + "Looking for paths with length: 1 for node RELA_S536 and AKT1S1\n", + "i_search = 4\n", + "Looking for paths with length: 2 for node RELA_S536 and AKT1S1\n", + "i_search = 4\n", + "Looking for paths with length: 3 for node RELA_S536 and AKT1S1\n", + "i_search = 4\n", + "Looking for paths with length: 4 for node RELA_S536 and AKT1S1\n", + "looking for paths in the network with length: 0 for node RELA_S536 and GSK3B\n", + "looking for paths in the network with length: 1 for node RELA_S536 and GSK3B\n", + "looking for paths in the network with length: 2 for node RELA_S536 and GSK3B\n", + "looking for paths in the network with length: 3 for node RELA_S536 and GSK3B\n", + "looking for paths in the network with length: 4 for node RELA_S536 and GSK3B\n", + "looking for paths in the network with length: 5 for node RELA_S536 and GSK3B\n", + "looking for paths in the network with length: 6 for node RELA_S536 and GSK3B\n", + "looking for paths in the network with length: 7 for node RELA_S536 and GSK3B\n", + "looking for paths in the network with length: 8 for node RELA_S536 and GSK3B\n", + "looking for paths in the network with length: 9 for node RELA_S536 and GSK3B\n", + "looking for paths in the network with length: 10 for node RELA_S536 and GSK3B\n", + "i_search = 4\n", + "Looking for paths with length: 0 for node RELA_S536 and GSK3B\n", + "i_search = 4\n", + "Looking for paths with length: 1 for node RELA_S536 and GSK3B\n", + "i_search = 4\n", + "Looking for paths with length: 2 for node RELA_S536 and GSK3B\n", + "i_search = 4\n", + "Looking for paths with length: 3 for node RELA_S536 and GSK3B\n", + "i_search = 4\n", + "Looking for paths with length: 4 for node RELA_S536 and GSK3B\n", + "looking for paths in the network with length: 0 for node RELA_S536 and AKT1\n", + "looking for paths in the network with length: 1 for node RELA_S536 and AKT1\n", + "looking for paths in the network with length: 2 for node RELA_S536 and AKT1\n", + "looking for paths in the network with length: 3 for node RELA_S536 and AKT1\n", + "looking for paths in the network with length: 4 for node RELA_S536 and AKT1\n", + "looking for paths in the network with length: 5 for node RELA_S536 and AKT1\n", + "looking for paths in the network with length: 6 for node RELA_S536 and AKT1\n", + "looking for paths in the network with length: 7 for node RELA_S536 and AKT1\n", + "looking for paths in the network with length: 8 for node RELA_S536 and AKT1\n", + "looking for paths in the network with length: 9 for node RELA_S536 and AKT1\n", + "looking for paths in the network with length: 10 for node RELA_S536 and AKT1\n", + "i_search = 4\n", + "Looking for paths with length: 0 for node RELA_S536 and AKT1\n", + "i_search = 4\n", + "Looking for paths with length: 1 for node RELA_S536 and AKT1\n", + "i_search = 4\n", + "Looking for paths with length: 2 for node RELA_S536 and AKT1\n", + "i_search = 4\n", + "Looking for paths with length: 3 for node RELA_S536 and AKT1\n", + "i_search = 4\n", + "Looking for paths with length: 4 for node RELA_S536 and AKT1\n", + "looking for paths in the network with length: 0 for node RELA_S536 and HSPB1\n", + "looking for paths in the network with length: 1 for node RELA_S536 and HSPB1\n", + "looking for paths in the network with length: 2 for node RELA_S536 and HSPB1\n", + "looking for paths in the network with length: 3 for node RELA_S536 and HSPB1\n", + "looking for paths in the network with length: 4 for node RELA_S536 and HSPB1\n", + "looking for paths in the network with length: 5 for node RELA_S536 and HSPB1\n", + "looking for paths in the network with length: 6 for node RELA_S536 and HSPB1\n", + "looking for paths in the network with length: 7 for node RELA_S536 and HSPB1\n", + "looking for paths in the network with length: 8 for node RELA_S536 and HSPB1\n", + "looking for paths in the network with length: 9 for node RELA_S536 and HSPB1\n", + "looking for paths in the network with length: 10 for node RELA_S536 and HSPB1\n", + "i_search = 4\n", + "Looking for paths with length: 0 for node RELA_S536 and HSPB1\n", + "i_search = 4\n", + "Looking for paths with length: 1 for node RELA_S536 and HSPB1\n", + "i_search = 4\n", + "Looking for paths with length: 2 for node RELA_S536 and HSPB1\n", + "i_search = 4\n", + "Looking for paths with length: 3 for node RELA_S536 and HSPB1\n", + "i_search = 4\n", + "Looking for paths with length: 4 for node RELA_S536 and HSPB1\n", + "looking for paths in the network with length: 0 for node RELA_S536 and MAPK14\n", + "looking for paths in the network with length: 1 for node RELA_S536 and MAPK14\n", + "looking for paths in the network with length: 2 for node RELA_S536 and MAPK14\n", + "looking for paths in the network with length: 3 for node RELA_S536 and MAPK14\n", + "looking for paths in the network with length: 4 for node RELA_S536 and MAPK14\n", + "looking for paths in the network with length: 5 for node RELA_S536 and MAPK14\n", + "looking for paths in the network with length: 6 for node RELA_S536 and MAPK14\n", + "looking for paths in the network with length: 7 for node RELA_S536 and MAPK14\n", + "looking for paths in the network with length: 8 for node RELA_S536 and MAPK14\n", + "looking for paths in the network with length: 9 for node RELA_S536 and MAPK14\n", + "looking for paths in the network with length: 10 for node RELA_S536 and MAPK14\n", + "i_search = 4\n", + "Looking for paths with length: 0 for node RELA_S536 and MAPK14\n", + "i_search = 4\n", + "Looking for paths with length: 1 for node RELA_S536 and MAPK14\n", + "i_search = 4\n", + "Looking for paths with length: 2 for node RELA_S536 and MAPK14\n", + "i_search = 4\n", + "Looking for paths with length: 3 for node RELA_S536 and MAPK14\n", + "i_search = 4\n", + "Looking for paths with length: 4 for node RELA_S536 and MAPK14\n", + "looking for paths in the network with length: 0 for node RELA_S536 and MAP2K1\n", + "looking for paths in the network with length: 1 for node RELA_S536 and MAP2K1\n", + "looking for paths in the network with length: 2 for node RELA_S536 and MAP2K1\n", + "looking for paths in the network with length: 3 for node RELA_S536 and MAP2K1\n", + "looking for paths in the network with length: 4 for node RELA_S536 and MAP2K1\n", + "looking for paths in the network with length: 5 for node RELA_S536 and MAP2K1\n", + "looking for paths in the network with length: 6 for node RELA_S536 and MAP2K1\n", + "looking for paths in the network with length: 7 for node RELA_S536 and MAP2K1\n", + "looking for paths in the network with length: 8 for node RELA_S536 and MAP2K1\n", + "looking for paths in the network with length: 9 for node RELA_S536 and MAP2K1\n", + "looking for paths in the network with length: 10 for node RELA_S536 and MAP2K1\n", + "i_search = 4\n", + "Looking for paths with length: 0 for node RELA_S536 and MAP2K1\n", + "i_search = 4\n", + "Looking for paths with length: 1 for node RELA_S536 and MAP2K1\n", + "i_search = 4\n", + "Looking for paths with length: 2 for node RELA_S536 and MAP2K1\n", + "i_search = 4\n", + "Looking for paths with length: 3 for node RELA_S536 and MAP2K1\n", + "i_search = 4\n", + "Looking for paths with length: 4 for node RELA_S536 and MAP2K1\n", + "looking for paths in the network with length: 0 for node RELA_S536 and RPS6KA1\n", + "looking for paths in the network with length: 1 for node RELA_S536 and RPS6KA1\n", + "looking for paths in the network with length: 2 for node RELA_S536 and RPS6KA1\n", + "looking for paths in the network with length: 3 for node RELA_S536 and RPS6KA1\n", + "looking for paths in the network with length: 4 for node RELA_S536 and RPS6KA1\n", + "looking for paths in the network with length: 5 for node RELA_S536 and RPS6KA1\n", + "looking for paths in the network with length: 6 for node RELA_S536 and RPS6KA1\n", + "looking for paths in the network with length: 7 for node RELA_S536 and RPS6KA1\n", + "looking for paths in the network with length: 8 for node RELA_S536 and RPS6KA1\n", + "looking for paths in the network with length: 9 for node RELA_S536 and RPS6KA1\n", + "looking for paths in the network with length: 10 for node RELA_S536 and RPS6KA1\n", + "i_search = 4\n", + "Looking for paths with length: 0 for node RELA_S536 and RPS6KA1\n", + "i_search = 4\n", + "Looking for paths with length: 1 for node RELA_S536 and RPS6KA1\n", + "i_search = 4\n", + "Looking for paths with length: 2 for node RELA_S536 and RPS6KA1\n", + "i_search = 4\n", + "Looking for paths with length: 3 for node RELA_S536 and RPS6KA1\n", + "i_search = 4\n", + "Looking for paths with length: 4 for node RELA_S536 and RPS6KA1\n", + "looking for paths in the network with length: 0 for node RELA_S536 and CREB1\n", + "looking for paths in the network with length: 1 for node RELA_S536 and CREB1\n", + "looking for paths in the network with length: 2 for node RELA_S536 and CREB1\n", + "looking for paths in the network with length: 3 for node RELA_S536 and CREB1\n", + "looking for paths in the network with length: 4 for node RELA_S536 and CREB1\n", + "looking for paths in the network with length: 5 for node RELA_S536 and CREB1\n", + "looking for paths in the network with length: 6 for node RELA_S536 and CREB1\n", + "looking for paths in the network with length: 7 for node RELA_S536 and CREB1\n", + "looking for paths in the network with length: 8 for node RELA_S536 and CREB1\n", + "looking for paths in the network with length: 9 for node RELA_S536 and CREB1\n", + "looking for paths in the network with length: 10 for node RELA_S536 and CREB1\n", + "i_search = 4\n", + "Looking for paths with length: 0 for node RELA_S536 and CREB1\n", + "i_search = 4\n", + "Looking for paths with length: 1 for node RELA_S536 and CREB1\n", + "i_search = 4\n", + "Looking for paths with length: 2 for node RELA_S536 and CREB1\n", + "i_search = 4\n", + "Looking for paths with length: 3 for node RELA_S536 and CREB1\n", + "i_search = 4\n", + "Looking for paths with length: 4 for node RELA_S536 and CREB1\n", + "looking for paths in the network with length: 0 for node RELA_S536 and NFKBIA\n", + "looking for paths in the network with length: 1 for node RELA_S536 and NFKBIA\n", + "looking for paths in the network with length: 2 for node RELA_S536 and NFKBIA\n", + "looking for paths in the network with length: 3 for node RELA_S536 and NFKBIA\n", + "looking for paths in the network with length: 4 for node RELA_S536 and NFKBIA\n", + "looking for paths in the network with length: 5 for node RELA_S536 and NFKBIA\n", + "looking for paths in the network with length: 6 for node RELA_S536 and NFKBIA\n", + "looking for paths in the network with length: 7 for node RELA_S536 and NFKBIA\n", + "looking for paths in the network with length: 8 for node RELA_S536 and NFKBIA\n", + "looking for paths in the network with length: 9 for node RELA_S536 and NFKBIA\n", + "looking for paths in the network with length: 10 for node RELA_S536 and NFKBIA\n", + "i_search = 4\n", + "Looking for paths with length: 0 for node RELA_S536 and NFKBIA\n", + "i_search = 4\n", + "Looking for paths with length: 1 for node RELA_S536 and NFKBIA\n", + "i_search = 4\n", + "Looking for paths with length: 2 for node RELA_S536 and NFKBIA\n", + "i_search = 4\n", + "Looking for paths with length: 3 for node RELA_S536 and NFKBIA\n", + "i_search = 4\n", + "Looking for paths with length: 4 for node RELA_S536 and NFKBIA\n", + "looking for paths in the network with length: 0 for node RELA_S536 and MTOR\n", + "looking for paths in the network with length: 1 for node RELA_S536 and MTOR\n", + "looking for paths in the network with length: 2 for node RELA_S536 and MTOR\n", + "looking for paths in the network with length: 3 for node RELA_S536 and MTOR\n", + "looking for paths in the network with length: 4 for node RELA_S536 and MTOR\n", + "looking for paths in the network with length: 5 for node RELA_S536 and MTOR\n", + "looking for paths in the network with length: 6 for node RELA_S536 and MTOR\n", + "looking for paths in the network with length: 7 for node RELA_S536 and MTOR\n", + "looking for paths in the network with length: 8 for node RELA_S536 and MTOR\n", + "looking for paths in the network with length: 9 for node RELA_S536 and MTOR\n", + "looking for paths in the network with length: 10 for node RELA_S536 and MTOR\n", + "i_search = 4\n", + "Looking for paths with length: 0 for node RELA_S536 and MTOR\n", + "i_search = 4\n", + "Looking for paths with length: 1 for node RELA_S536 and MTOR\n", + "i_search = 4\n", + "Looking for paths with length: 2 for node RELA_S536 and MTOR\n", + "i_search = 4\n", + "Looking for paths with length: 3 for node RELA_S536 and MTOR\n", + "i_search = 4\n", + "Looking for paths with length: 4 for node RELA_S536 and MTOR\n", + "looking for paths in the network with length: 0 for node RELA_S536 and JUN\n", + "looking for paths in the network with length: 1 for node RELA_S536 and JUN\n", + "looking for paths in the network with length: 2 for node RELA_S536 and JUN\n", + "looking for paths in the network with length: 3 for node RELA_S536 and JUN\n", + "looking for paths in the network with length: 4 for node RELA_S536 and JUN\n", + "looking for paths in the network with length: 5 for node RELA_S536 and JUN\n", + "looking for paths in the network with length: 6 for node RELA_S536 and JUN\n", + "looking for paths in the network with length: 7 for node RELA_S536 and JUN\n", + "looking for paths in the network with length: 8 for node RELA_S536 and JUN\n", + "looking for paths in the network with length: 9 for node RELA_S536 and JUN\n", + "looking for paths in the network with length: 10 for node RELA_S536 and JUN\n", + "i_search = 4\n", + "Looking for paths with length: 0 for node RELA_S536 and JUN\n", + "i_search = 4\n", + "Looking for paths with length: 1 for node RELA_S536 and JUN\n", + "i_search = 4\n", + "Looking for paths with length: 2 for node RELA_S536 and JUN\n", + "i_search = 4\n", + "Looking for paths with length: 3 for node RELA_S536 and JUN\n", + "i_search = 4\n", + "Looking for paths with length: 4 for node RELA_S536 and JUN\n", + "looking for paths in the network with length: 0 for node RELA_S536 and EGFR\n", + "looking for paths in the network with length: 1 for node RELA_S536 and EGFR\n", + "looking for paths in the network with length: 2 for node RELA_S536 and EGFR\n", + "looking for paths in the network with length: 3 for node RELA_S536 and EGFR\n", + "looking for paths in the network with length: 4 for node RELA_S536 and EGFR\n", + "looking for paths in the network with length: 5 for node RELA_S536 and EGFR\n", + "looking for paths in the network with length: 6 for node RELA_S536 and EGFR\n", + "looking for paths in the network with length: 7 for node RELA_S536 and EGFR\n", + "looking for paths in the network with length: 8 for node RELA_S536 and EGFR\n", + "looking for paths in the network with length: 9 for node RELA_S536 and EGFR\n", + "looking for paths in the network with length: 10 for node RELA_S536 and EGFR\n", + "i_search = 4\n", + "Looking for paths with length: 0 for node RELA_S536 and EGFR\n", + "i_search = 4\n", + "Looking for paths with length: 1 for node RELA_S536 and EGFR\n", + "i_search = 4\n", + "Looking for paths with length: 2 for node RELA_S536 and EGFR\n", + "i_search = 4\n", + "Looking for paths with length: 3 for node RELA_S536 and EGFR\n", + "i_search = 4\n", + "Looking for paths with length: 4 for node RELA_S536 and EGFR\n", + "looking for paths in the network with length: 0 for node RELA_S536 and MAPK3\n", + "looking for paths in the network with length: 1 for node RELA_S536 and MAPK3\n", + "looking for paths in the network with length: 2 for node RELA_S536 and MAPK3\n", + "looking for paths in the network with length: 3 for node RELA_S536 and MAPK3\n", + "looking for paths in the network with length: 4 for node RELA_S536 and MAPK3\n", + "looking for paths in the network with length: 5 for node RELA_S536 and MAPK3\n", + "looking for paths in the network with length: 6 for node RELA_S536 and MAPK3\n", + "looking for paths in the network with length: 7 for node RELA_S536 and MAPK3\n", + "looking for paths in the network with length: 8 for node RELA_S536 and MAPK3\n", + "looking for paths in the network with length: 9 for node RELA_S536 and MAPK3\n", + "looking for paths in the network with length: 10 for node RELA_S536 and MAPK3\n", + "i_search = 4\n", + "Looking for paths with length: 0 for node RELA_S536 and MAPK3\n", + "i_search = 4\n", + "Looking for paths with length: 1 for node RELA_S536 and MAPK3\n", + "i_search = 4\n", + "Looking for paths with length: 2 for node RELA_S536 and MAPK3\n", + "i_search = 4\n", + "Looking for paths with length: 3 for node RELA_S536 and MAPK3\n", + "i_search = 4\n", + "Looking for paths with length: 4 for node RELA_S536 and MAPK3\n", + "looking for paths in the network with length: 0 for node RELA_S536 and PTPN11\n", + "looking for paths in the network with length: 1 for node RELA_S536 and PTPN11\n", + "looking for paths in the network with length: 2 for node RELA_S536 and PTPN11\n", + "looking for paths in the network with length: 3 for node RELA_S536 and PTPN11\n", + "looking for paths in the network with length: 4 for node RELA_S536 and PTPN11\n", + "looking for paths in the network with length: 5 for node RELA_S536 and PTPN11\n", + "looking for paths in the network with length: 6 for node RELA_S536 and PTPN11\n", + "looking for paths in the network with length: 7 for node RELA_S536 and PTPN11\n", + "looking for paths in the network with length: 8 for node RELA_S536 and PTPN11\n", + "looking for paths in the network with length: 9 for node RELA_S536 and PTPN11\n", + "looking for paths in the network with length: 10 for node RELA_S536 and PTPN11\n", + "i_search = 4\n", + "Looking for paths with length: 0 for node RELA_S536 and PTPN11\n", + "i_search = 4\n", + "Looking for paths with length: 1 for node RELA_S536 and PTPN11\n", + "i_search = 4\n", + "Looking for paths with length: 2 for node RELA_S536 and PTPN11\n", + "i_search = 4\n", + "Looking for paths with length: 3 for node RELA_S536 and PTPN11\n", + "i_search = 4\n", + "Looking for paths with length: 4 for node RELA_S536 and PTPN11\n", + "looking for paths in the network with length: 0 for node RELA_S536 and STAT3\n", + "looking for paths in the network with length: 1 for node RELA_S536 and STAT3\n", + "looking for paths in the network with length: 2 for node RELA_S536 and STAT3\n", + "looking for paths in the network with length: 3 for node RELA_S536 and STAT3\n", + "looking for paths in the network with length: 4 for node RELA_S536 and STAT3\n", + "looking for paths in the network with length: 5 for node RELA_S536 and STAT3\n", + "looking for paths in the network with length: 6 for node RELA_S536 and STAT3\n", + "looking for paths in the network with length: 7 for node RELA_S536 and STAT3\n", + "looking for paths in the network with length: 8 for node RELA_S536 and STAT3\n", + "looking for paths in the network with length: 9 for node RELA_S536 and STAT3\n", + "looking for paths in the network with length: 10 for node RELA_S536 and STAT3\n", + "i_search = 4\n", + "Looking for paths with length: 0 for node RELA_S536 and STAT3\n", + "i_search = 4\n", + "Looking for paths with length: 1 for node RELA_S536 and STAT3\n", + "i_search = 4\n", + "Looking for paths with length: 2 for node RELA_S536 and STAT3\n", + "i_search = 4\n", + "Looking for paths with length: 3 for node RELA_S536 and STAT3\n", + "i_search = 4\n", + "Looking for paths with length: 4 for node RELA_S536 and STAT3\n", + "looking for paths in the network with length: 0 for node RELA_S536 and CHEK2\n", + "looking for paths in the network with length: 1 for node RELA_S536 and CHEK2\n", + "looking for paths in the network with length: 2 for node RELA_S536 and CHEK2\n", + "looking for paths in the network with length: 3 for node RELA_S536 and CHEK2\n", + "looking for paths in the network with length: 4 for node RELA_S536 and CHEK2\n", + "looking for paths in the network with length: 5 for node RELA_S536 and CHEK2\n", + "looking for paths in the network with length: 6 for node RELA_S536 and CHEK2\n", + "looking for paths in the network with length: 7 for node RELA_S536 and CHEK2\n", + "looking for paths in the network with length: 8 for node RELA_S536 and CHEK2\n", + "looking for paths in the network with length: 9 for node RELA_S536 and CHEK2\n", + "looking for paths in the network with length: 10 for node RELA_S536 and CHEK2\n", + "i_search = 4\n", + "Looking for paths with length: 0 for node RELA_S536 and CHEK2\n", + "i_search = 4\n", + "Looking for paths with length: 1 for node RELA_S536 and CHEK2\n", + "i_search = 4\n", + "Looking for paths with length: 2 for node RELA_S536 and CHEK2\n", + "i_search = 4\n", + "Looking for paths with length: 3 for node RELA_S536 and CHEK2\n", + "i_search = 4\n", + "Looking for paths with length: 4 for node RELA_S536 and CHEK2\n", + "looking for paths in the network with length: 0 for node RELA_S536 and RELA\n", + "looking for paths in the network with length: 1 for node RELA_S536 and RELA\n", + "looking for paths in the network with length: 2 for node RELA_S536 and RELA\n", + "looking for paths in the network with length: 3 for node RELA_S536 and RELA\n", + "looking for paths in the network with length: 4 for node RELA_S536 and RELA\n", + "looking for paths in the network with length: 5 for node RELA_S536 and RELA\n", + "looking for paths in the network with length: 6 for node RELA_S536 and RELA\n", + "looking for paths in the network with length: 7 for node RELA_S536 and RELA\n", + "looking for paths in the network with length: 8 for node RELA_S536 and RELA\n", + "looking for paths in the network with length: 9 for node RELA_S536 and RELA\n", + "looking for paths in the network with length: 10 for node RELA_S536 and RELA\n", + "i_search = 4\n", + "Looking for paths with length: 0 for node RELA_S536 and RELA\n", + "i_search = 4\n", + "Looking for paths with length: 1 for node RELA_S536 and RELA\n", + "i_search = 4\n", + "Looking for paths with length: 2 for node RELA_S536 and RELA\n", + "i_search = 4\n", + "Looking for paths with length: 3 for node RELA_S536 and RELA\n", + "i_search = 4\n", + "Looking for paths with length: 4 for node RELA_S536 and RELA\n", + "looking for paths in the network with length: 0 for node RELA_S536 and MARCKS\n", + "looking for paths in the network with length: 1 for node RELA_S536 and MARCKS\n", + "looking for paths in the network with length: 2 for node RELA_S536 and MARCKS\n", + "looking for paths in the network with length: 3 for node RELA_S536 and MARCKS\n", + "looking for paths in the network with length: 4 for node RELA_S536 and MARCKS\n", + "looking for paths in the network with length: 5 for node RELA_S536 and MARCKS\n", + "looking for paths in the network with length: 6 for node RELA_S536 and MARCKS\n", + "looking for paths in the network with length: 7 for node RELA_S536 and MARCKS\n", + "looking for paths in the network with length: 8 for node RELA_S536 and MARCKS\n", + "looking for paths in the network with length: 9 for node RELA_S536 and MARCKS\n", + "looking for paths in the network with length: 10 for node RELA_S536 and MARCKS\n", + "i_search = 4\n", + "Looking for paths with length: 0 for node RELA_S536 and MARCKS\n", + "i_search = 4\n", + "Looking for paths with length: 1 for node RELA_S536 and MARCKS\n", + "i_search = 4\n", + "Looking for paths with length: 2 for node RELA_S536 and MARCKS\n", + "i_search = 4\n", + "Looking for paths with length: 3 for node RELA_S536 and MARCKS\n", + "i_search = 4\n", + "Looking for paths with length: 4 for node RELA_S536 and MARCKS\n", + "looking for paths in the network with length: 0 for node MARCKS_S170 and SMAD3\n", + "looking for paths in the network with length: 1 for node MARCKS_S170 and SMAD3\n", + "looking for paths in the network with length: 2 for node MARCKS_S170 and SMAD3\n", + "looking for paths in the network with length: 3 for node MARCKS_S170 and SMAD3\n", + "looking for paths in the network with length: 4 for node MARCKS_S170 and SMAD3\n", + "looking for paths in the network with length: 5 for node MARCKS_S170 and SMAD3\n", + "looking for paths in the network with length: 6 for node MARCKS_S170 and SMAD3\n", + "looking for paths in the network with length: 7 for node MARCKS_S170 and SMAD3\n", + "looking for paths in the network with length: 8 for node MARCKS_S170 and SMAD3\n", + "looking for paths in the network with length: 9 for node MARCKS_S170 and SMAD3\n", + "looking for paths in the network with length: 10 for node MARCKS_S170 and SMAD3\n", + "i_search = 4\n", + "Looking for paths with length: 0 for node MARCKS_S170 and SMAD3\n", + "i_search = 4\n", + "Looking for paths with length: 1 for node MARCKS_S170 and SMAD3\n", + "i_search = 4\n", + "Looking for paths with length: 2 for node MARCKS_S170 and SMAD3\n", + "i_search = 4\n", + "Looking for paths with length: 3 for node MARCKS_S170 and SMAD3\n", + "i_search = 4\n", + "Looking for paths with length: 4 for node MARCKS_S170 and SMAD3\n", + "looking for paths in the network with length: 0 for node MARCKS_S170 and TP53\n", + "looking for paths in the network with length: 1 for node MARCKS_S170 and TP53\n", + "looking for paths in the network with length: 2 for node MARCKS_S170 and TP53\n", + "looking for paths in the network with length: 3 for node MARCKS_S170 and TP53\n", + "looking for paths in the network with length: 4 for node MARCKS_S170 and TP53\n", + "looking for paths in the network with length: 5 for node MARCKS_S170 and TP53\n", + "looking for paths in the network with length: 6 for node MARCKS_S170 and TP53\n", + "looking for paths in the network with length: 7 for node MARCKS_S170 and TP53\n", + "looking for paths in the network with length: 8 for node MARCKS_S170 and TP53\n", + "looking for paths in the network with length: 9 for node MARCKS_S170 and TP53\n", + "looking for paths in the network with length: 10 for node MARCKS_S170 and TP53\n", + "i_search = 4\n", + "Looking for paths with length: 0 for node MARCKS_S170 and TP53\n", + "i_search = 4\n", + "Looking for paths with length: 1 for node MARCKS_S170 and TP53\n", + "i_search = 4\n", + "Looking for paths with length: 2 for node MARCKS_S170 and TP53\n", + "i_search = 4\n", + "Looking for paths with length: 3 for node MARCKS_S170 and TP53\n", + "i_search = 4\n", + "Looking for paths with length: 4 for node MARCKS_S170 and TP53\n", + "looking for paths in the network with length: 0 for node MARCKS_S170 and AKT1S1\n", + "looking for paths in the network with length: 1 for node MARCKS_S170 and AKT1S1\n", + "looking for paths in the network with length: 2 for node MARCKS_S170 and AKT1S1\n", + "looking for paths in the network with length: 3 for node MARCKS_S170 and AKT1S1\n", + "looking for paths in the network with length: 4 for node MARCKS_S170 and AKT1S1\n", + "looking for paths in the network with length: 5 for node MARCKS_S170 and AKT1S1\n", + "looking for paths in the network with length: 6 for node MARCKS_S170 and AKT1S1\n", + "looking for paths in the network with length: 7 for node MARCKS_S170 and AKT1S1\n", + "looking for paths in the network with length: 8 for node MARCKS_S170 and AKT1S1\n", + "looking for paths in the network with length: 9 for node MARCKS_S170 and AKT1S1\n", + "looking for paths in the network with length: 10 for node MARCKS_S170 and AKT1S1\n", + "i_search = 4\n", + "Looking for paths with length: 0 for node MARCKS_S170 and AKT1S1\n", + "i_search = 4\n", + "Looking for paths with length: 1 for node MARCKS_S170 and AKT1S1\n", + "i_search = 4\n", + "Looking for paths with length: 2 for node MARCKS_S170 and AKT1S1\n", + "i_search = 4\n", + "Looking for paths with length: 3 for node MARCKS_S170 and AKT1S1\n", + "i_search = 4\n", + "Looking for paths with length: 4 for node MARCKS_S170 and AKT1S1\n", + "looking for paths in the network with length: 0 for node MARCKS_S170 and GSK3B\n", + "looking for paths in the network with length: 1 for node MARCKS_S170 and GSK3B\n", + "looking for paths in the network with length: 2 for node MARCKS_S170 and GSK3B\n", + "looking for paths in the network with length: 3 for node MARCKS_S170 and GSK3B\n", + "looking for paths in the network with length: 4 for node MARCKS_S170 and GSK3B\n", + "looking for paths in the network with length: 5 for node MARCKS_S170 and GSK3B\n", + "looking for paths in the network with length: 6 for node MARCKS_S170 and GSK3B\n", + "looking for paths in the network with length: 7 for node MARCKS_S170 and GSK3B\n", + "looking for paths in the network with length: 8 for node MARCKS_S170 and GSK3B\n", + "looking for paths in the network with length: 9 for node MARCKS_S170 and GSK3B\n", + "looking for paths in the network with length: 10 for node MARCKS_S170 and GSK3B\n", + "i_search = 4\n", + "Looking for paths with length: 0 for node MARCKS_S170 and GSK3B\n", + "i_search = 4\n", + "Looking for paths with length: 1 for node MARCKS_S170 and GSK3B\n", + "i_search = 4\n", + "Looking for paths with length: 2 for node MARCKS_S170 and GSK3B\n", + "i_search = 4\n", + "Looking for paths with length: 3 for node MARCKS_S170 and GSK3B\n", + "i_search = 4\n", + "Looking for paths with length: 4 for node MARCKS_S170 and GSK3B\n", + "looking for paths in the network with length: 0 for node MARCKS_S170 and AKT1\n", + "looking for paths in the network with length: 1 for node MARCKS_S170 and AKT1\n", + "looking for paths in the network with length: 2 for node MARCKS_S170 and AKT1\n", + "looking for paths in the network with length: 3 for node MARCKS_S170 and AKT1\n", + "looking for paths in the network with length: 4 for node MARCKS_S170 and AKT1\n", + "looking for paths in the network with length: 5 for node MARCKS_S170 and AKT1\n", + "looking for paths in the network with length: 6 for node MARCKS_S170 and AKT1\n", + "looking for paths in the network with length: 7 for node MARCKS_S170 and AKT1\n", + "looking for paths in the network with length: 8 for node MARCKS_S170 and AKT1\n", + "looking for paths in the network with length: 9 for node MARCKS_S170 and AKT1\n", + "looking for paths in the network with length: 10 for node MARCKS_S170 and AKT1\n", + "i_search = 4\n", + "Looking for paths with length: 0 for node MARCKS_S170 and AKT1\n", + "i_search = 4\n", + "Looking for paths with length: 1 for node MARCKS_S170 and AKT1\n", + "i_search = 4\n", + "Looking for paths with length: 2 for node MARCKS_S170 and AKT1\n", + "i_search = 4\n", + "Looking for paths with length: 3 for node MARCKS_S170 and AKT1\n", + "i_search = 4\n", + "Looking for paths with length: 4 for node MARCKS_S170 and AKT1\n", + "looking for paths in the network with length: 0 for node MARCKS_S170 and HSPB1\n", + "looking for paths in the network with length: 1 for node MARCKS_S170 and HSPB1\n", + "looking for paths in the network with length: 2 for node MARCKS_S170 and HSPB1\n", + "looking for paths in the network with length: 3 for node MARCKS_S170 and HSPB1\n", + "looking for paths in the network with length: 4 for node MARCKS_S170 and HSPB1\n", + "looking for paths in the network with length: 5 for node MARCKS_S170 and HSPB1\n", + "looking for paths in the network with length: 6 for node MARCKS_S170 and HSPB1\n", + "looking for paths in the network with length: 7 for node MARCKS_S170 and HSPB1\n", + "looking for paths in the network with length: 8 for node MARCKS_S170 and HSPB1\n", + "looking for paths in the network with length: 9 for node MARCKS_S170 and HSPB1\n", + "looking for paths in the network with length: 10 for node MARCKS_S170 and HSPB1\n", + "i_search = 4\n", + "Looking for paths with length: 0 for node MARCKS_S170 and HSPB1\n", + "i_search = 4\n", + "Looking for paths with length: 1 for node MARCKS_S170 and HSPB1\n", + "i_search = 4\n", + "Looking for paths with length: 2 for node MARCKS_S170 and HSPB1\n", + "i_search = 4\n", + "Looking for paths with length: 3 for node MARCKS_S170 and HSPB1\n", + "i_search = 4\n", + "Looking for paths with length: 4 for node MARCKS_S170 and HSPB1\n", + "looking for paths in the network with length: 0 for node MARCKS_S170 and MAPK14\n", + "looking for paths in the network with length: 1 for node MARCKS_S170 and MAPK14\n", + "looking for paths in the network with length: 2 for node MARCKS_S170 and MAPK14\n", + "looking for paths in the network with length: 3 for node MARCKS_S170 and MAPK14\n", + "looking for paths in the network with length: 4 for node MARCKS_S170 and MAPK14\n", + "looking for paths in the network with length: 5 for node MARCKS_S170 and MAPK14\n", + "looking for paths in the network with length: 6 for node MARCKS_S170 and MAPK14\n", + "looking for paths in the network with length: 7 for node MARCKS_S170 and MAPK14\n", + "looking for paths in the network with length: 8 for node MARCKS_S170 and MAPK14\n", + "looking for paths in the network with length: 9 for node MARCKS_S170 and MAPK14\n", + "looking for paths in the network with length: 10 for node MARCKS_S170 and MAPK14\n", + "i_search = 4\n", + "Looking for paths with length: 0 for node MARCKS_S170 and MAPK14\n", + "i_search = 4\n", + "Looking for paths with length: 1 for node MARCKS_S170 and MAPK14\n", + "i_search = 4\n", + "Looking for paths with length: 2 for node MARCKS_S170 and MAPK14\n", + "i_search = 4\n", + "Looking for paths with length: 3 for node MARCKS_S170 and MAPK14\n", + "i_search = 4\n", + "Looking for paths with length: 4 for node MARCKS_S170 and MAPK14\n", + "looking for paths in the network with length: 0 for node MARCKS_S170 and MAP2K1\n", + "looking for paths in the network with length: 1 for node MARCKS_S170 and MAP2K1\n", + "looking for paths in the network with length: 2 for node MARCKS_S170 and MAP2K1\n", + "looking for paths in the network with length: 3 for node MARCKS_S170 and MAP2K1\n", + "looking for paths in the network with length: 4 for node MARCKS_S170 and MAP2K1\n", + "looking for paths in the network with length: 5 for node MARCKS_S170 and MAP2K1\n", + "looking for paths in the network with length: 6 for node MARCKS_S170 and MAP2K1\n", + "looking for paths in the network with length: 7 for node MARCKS_S170 and MAP2K1\n", + "looking for paths in the network with length: 8 for node MARCKS_S170 and MAP2K1\n", + "looking for paths in the network with length: 9 for node MARCKS_S170 and MAP2K1\n", + "looking for paths in the network with length: 10 for node MARCKS_S170 and MAP2K1\n", + "i_search = 4\n", + "Looking for paths with length: 0 for node MARCKS_S170 and MAP2K1\n", + "i_search = 4\n", + "Looking for paths with length: 1 for node MARCKS_S170 and MAP2K1\n", + "i_search = 4\n", + "Looking for paths with length: 2 for node MARCKS_S170 and MAP2K1\n", + "i_search = 4\n", + "Looking for paths with length: 3 for node MARCKS_S170 and MAP2K1\n", + "i_search = 4\n", + "Looking for paths with length: 4 for node MARCKS_S170 and MAP2K1\n", + "looking for paths in the network with length: 0 for node MARCKS_S170 and RPS6KA1\n", + "looking for paths in the network with length: 1 for node MARCKS_S170 and RPS6KA1\n", + "looking for paths in the network with length: 2 for node MARCKS_S170 and RPS6KA1\n", + "looking for paths in the network with length: 3 for node MARCKS_S170 and RPS6KA1\n", + "looking for paths in the network with length: 4 for node MARCKS_S170 and RPS6KA1\n", + "looking for paths in the network with length: 5 for node MARCKS_S170 and RPS6KA1\n", + "looking for paths in the network with length: 6 for node MARCKS_S170 and RPS6KA1\n", + "looking for paths in the network with length: 7 for node MARCKS_S170 and RPS6KA1\n", + "looking for paths in the network with length: 8 for node MARCKS_S170 and RPS6KA1\n", + "looking for paths in the network with length: 9 for node MARCKS_S170 and RPS6KA1\n", + "looking for paths in the network with length: 10 for node MARCKS_S170 and RPS6KA1\n", + "i_search = 4\n", + "Looking for paths with length: 0 for node MARCKS_S170 and RPS6KA1\n", + "i_search = 4\n", + "Looking for paths with length: 1 for node MARCKS_S170 and RPS6KA1\n", + "i_search = 4\n", + "Looking for paths with length: 2 for node MARCKS_S170 and RPS6KA1\n", + "i_search = 4\n", + "Looking for paths with length: 3 for node MARCKS_S170 and RPS6KA1\n", + "i_search = 4\n", + "Looking for paths with length: 4 for node MARCKS_S170 and RPS6KA1\n", + "looking for paths in the network with length: 0 for node MARCKS_S170 and CREB1\n", + "looking for paths in the network with length: 1 for node MARCKS_S170 and CREB1\n", + "looking for paths in the network with length: 2 for node MARCKS_S170 and CREB1\n", + "looking for paths in the network with length: 3 for node MARCKS_S170 and CREB1\n", + "looking for paths in the network with length: 4 for node MARCKS_S170 and CREB1\n", + "looking for paths in the network with length: 5 for node MARCKS_S170 and CREB1\n", + "looking for paths in the network with length: 6 for node MARCKS_S170 and CREB1\n", + "looking for paths in the network with length: 7 for node MARCKS_S170 and CREB1\n", + "looking for paths in the network with length: 8 for node MARCKS_S170 and CREB1\n", + "looking for paths in the network with length: 9 for node MARCKS_S170 and CREB1\n", + "looking for paths in the network with length: 10 for node MARCKS_S170 and CREB1\n", + "i_search = 4\n", + "Looking for paths with length: 0 for node MARCKS_S170 and CREB1\n", + "i_search = 4\n", + "Looking for paths with length: 1 for node MARCKS_S170 and CREB1\n", + "i_search = 4\n", + "Looking for paths with length: 2 for node MARCKS_S170 and CREB1\n", + "i_search = 4\n", + "Looking for paths with length: 3 for node MARCKS_S170 and CREB1\n", + "i_search = 4\n", + "Looking for paths with length: 4 for node MARCKS_S170 and CREB1\n", + "looking for paths in the network with length: 0 for node MARCKS_S170 and NFKBIA\n", + "looking for paths in the network with length: 1 for node MARCKS_S170 and NFKBIA\n", + "looking for paths in the network with length: 2 for node MARCKS_S170 and NFKBIA\n", + "looking for paths in the network with length: 3 for node MARCKS_S170 and NFKBIA\n", + "looking for paths in the network with length: 4 for node MARCKS_S170 and NFKBIA\n", + "looking for paths in the network with length: 5 for node MARCKS_S170 and NFKBIA\n", + "looking for paths in the network with length: 6 for node MARCKS_S170 and NFKBIA\n", + "looking for paths in the network with length: 7 for node MARCKS_S170 and NFKBIA\n", + "looking for paths in the network with length: 8 for node MARCKS_S170 and NFKBIA\n", + "looking for paths in the network with length: 9 for node MARCKS_S170 and NFKBIA\n", + "looking for paths in the network with length: 10 for node MARCKS_S170 and NFKBIA\n", + "i_search = 4\n", + "Looking for paths with length: 0 for node MARCKS_S170 and NFKBIA\n", + "i_search = 4\n", + "Looking for paths with length: 1 for node MARCKS_S170 and NFKBIA\n", + "i_search = 4\n", + "Looking for paths with length: 2 for node MARCKS_S170 and NFKBIA\n", + "i_search = 4\n", + "Looking for paths with length: 3 for node MARCKS_S170 and NFKBIA\n", + "i_search = 4\n", + "Looking for paths with length: 4 for node MARCKS_S170 and NFKBIA\n", + "looking for paths in the network with length: 0 for node MARCKS_S170 and MTOR\n", + "looking for paths in the network with length: 1 for node MARCKS_S170 and MTOR\n", + "looking for paths in the network with length: 2 for node MARCKS_S170 and MTOR\n", + "looking for paths in the network with length: 3 for node MARCKS_S170 and MTOR\n", + "looking for paths in the network with length: 4 for node MARCKS_S170 and MTOR\n", + "looking for paths in the network with length: 5 for node MARCKS_S170 and MTOR\n", + "looking for paths in the network with length: 6 for node MARCKS_S170 and MTOR\n", + "looking for paths in the network with length: 7 for node MARCKS_S170 and MTOR\n", + "looking for paths in the network with length: 8 for node MARCKS_S170 and MTOR\n", + "looking for paths in the network with length: 9 for node MARCKS_S170 and MTOR\n", + "looking for paths in the network with length: 10 for node MARCKS_S170 and MTOR\n", + "i_search = 4\n", + "Looking for paths with length: 0 for node MARCKS_S170 and MTOR\n", + "i_search = 4\n", + "Looking for paths with length: 1 for node MARCKS_S170 and MTOR\n", + "i_search = 4\n", + "Looking for paths with length: 2 for node MARCKS_S170 and MTOR\n", + "i_search = 4\n", + "Looking for paths with length: 3 for node MARCKS_S170 and MTOR\n", + "i_search = 4\n", + "Looking for paths with length: 4 for node MARCKS_S170 and MTOR\n", + "looking for paths in the network with length: 0 for node MARCKS_S170 and JUN\n", + "looking for paths in the network with length: 1 for node MARCKS_S170 and JUN\n", + "looking for paths in the network with length: 2 for node MARCKS_S170 and JUN\n", + "looking for paths in the network with length: 3 for node MARCKS_S170 and JUN\n", + "looking for paths in the network with length: 4 for node MARCKS_S170 and JUN\n", + "looking for paths in the network with length: 5 for node MARCKS_S170 and JUN\n", + "looking for paths in the network with length: 6 for node MARCKS_S170 and JUN\n", + "looking for paths in the network with length: 7 for node MARCKS_S170 and JUN\n", + "looking for paths in the network with length: 8 for node MARCKS_S170 and JUN\n", + "looking for paths in the network with length: 9 for node MARCKS_S170 and JUN\n", + "looking for paths in the network with length: 10 for node MARCKS_S170 and JUN\n", + "i_search = 4\n", + "Looking for paths with length: 0 for node MARCKS_S170 and JUN\n", + "i_search = 4\n", + "Looking for paths with length: 1 for node MARCKS_S170 and JUN\n", + "i_search = 4\n", + "Looking for paths with length: 2 for node MARCKS_S170 and JUN\n", + "i_search = 4\n", + "Looking for paths with length: 3 for node MARCKS_S170 and JUN\n", + "i_search = 4\n", + "Looking for paths with length: 4 for node MARCKS_S170 and JUN\n", + "looking for paths in the network with length: 0 for node MARCKS_S170 and EGFR\n", + "looking for paths in the network with length: 1 for node MARCKS_S170 and EGFR\n", + "looking for paths in the network with length: 2 for node MARCKS_S170 and EGFR\n", + "looking for paths in the network with length: 3 for node MARCKS_S170 and EGFR\n", + "looking for paths in the network with length: 4 for node MARCKS_S170 and EGFR\n", + "looking for paths in the network with length: 5 for node MARCKS_S170 and EGFR\n", + "looking for paths in the network with length: 6 for node MARCKS_S170 and EGFR\n", + "looking for paths in the network with length: 7 for node MARCKS_S170 and EGFR\n", + "looking for paths in the network with length: 8 for node MARCKS_S170 and EGFR\n", + "looking for paths in the network with length: 9 for node MARCKS_S170 and EGFR\n", + "looking for paths in the network with length: 10 for node MARCKS_S170 and EGFR\n", + "i_search = 4\n", + "Looking for paths with length: 0 for node MARCKS_S170 and EGFR\n", + "i_search = 4\n", + "Looking for paths with length: 1 for node MARCKS_S170 and EGFR\n", + "i_search = 4\n", + "Looking for paths with length: 2 for node MARCKS_S170 and EGFR\n", + "i_search = 4\n", + "Looking for paths with length: 3 for node MARCKS_S170 and EGFR\n", + "i_search = 4\n", + "Looking for paths with length: 4 for node MARCKS_S170 and EGFR\n", + "looking for paths in the network with length: 0 for node MARCKS_S170 and MAPK3\n", + "looking for paths in the network with length: 1 for node MARCKS_S170 and MAPK3\n", + "looking for paths in the network with length: 2 for node MARCKS_S170 and MAPK3\n", + "looking for paths in the network with length: 3 for node MARCKS_S170 and MAPK3\n", + "looking for paths in the network with length: 4 for node MARCKS_S170 and MAPK3\n", + "looking for paths in the network with length: 5 for node MARCKS_S170 and MAPK3\n", + "looking for paths in the network with length: 6 for node MARCKS_S170 and MAPK3\n", + "looking for paths in the network with length: 7 for node MARCKS_S170 and MAPK3\n", + "looking for paths in the network with length: 8 for node MARCKS_S170 and MAPK3\n", + "looking for paths in the network with length: 9 for node MARCKS_S170 and MAPK3\n", + "looking for paths in the network with length: 10 for node MARCKS_S170 and MAPK3\n", + "i_search = 4\n", + "Looking for paths with length: 0 for node MARCKS_S170 and MAPK3\n", + "i_search = 4\n", + "Looking for paths with length: 1 for node MARCKS_S170 and MAPK3\n", + "i_search = 4\n", + "Looking for paths with length: 2 for node MARCKS_S170 and MAPK3\n", + "i_search = 4\n", + "Looking for paths with length: 3 for node MARCKS_S170 and MAPK3\n", + "i_search = 4\n", + "Looking for paths with length: 4 for node MARCKS_S170 and MAPK3\n", + "looking for paths in the network with length: 0 for node MARCKS_S170 and PTPN11\n", + "looking for paths in the network with length: 1 for node MARCKS_S170 and PTPN11\n", + "looking for paths in the network with length: 2 for node MARCKS_S170 and PTPN11\n", + "looking for paths in the network with length: 3 for node MARCKS_S170 and PTPN11\n", + "looking for paths in the network with length: 4 for node MARCKS_S170 and PTPN11\n", + "looking for paths in the network with length: 5 for node MARCKS_S170 and PTPN11\n", + "looking for paths in the network with length: 6 for node MARCKS_S170 and PTPN11\n", + "looking for paths in the network with length: 7 for node MARCKS_S170 and PTPN11\n", + "looking for paths in the network with length: 8 for node MARCKS_S170 and PTPN11\n", + "looking for paths in the network with length: 9 for node MARCKS_S170 and PTPN11\n", + "looking for paths in the network with length: 10 for node MARCKS_S170 and PTPN11\n", + "i_search = 4\n", + "Looking for paths with length: 0 for node MARCKS_S170 and PTPN11\n", + "i_search = 4\n", + "Looking for paths with length: 1 for node MARCKS_S170 and PTPN11\n", + "i_search = 4\n", + "Looking for paths with length: 2 for node MARCKS_S170 and PTPN11\n", + "i_search = 4\n", + "Looking for paths with length: 3 for node MARCKS_S170 and PTPN11\n", + "i_search = 4\n", + "Looking for paths with length: 4 for node MARCKS_S170 and PTPN11\n", + "looking for paths in the network with length: 0 for node MARCKS_S170 and STAT3\n", + "looking for paths in the network with length: 1 for node MARCKS_S170 and STAT3\n", + "looking for paths in the network with length: 2 for node MARCKS_S170 and STAT3\n", + "looking for paths in the network with length: 3 for node MARCKS_S170 and STAT3\n", + "looking for paths in the network with length: 4 for node MARCKS_S170 and STAT3\n", + "looking for paths in the network with length: 5 for node MARCKS_S170 and STAT3\n", + "looking for paths in the network with length: 6 for node MARCKS_S170 and STAT3\n", + "looking for paths in the network with length: 7 for node MARCKS_S170 and STAT3\n", + "looking for paths in the network with length: 8 for node MARCKS_S170 and STAT3\n", + "looking for paths in the network with length: 9 for node MARCKS_S170 and STAT3\n", + "looking for paths in the network with length: 10 for node MARCKS_S170 and STAT3\n", + "i_search = 4\n", + "Looking for paths with length: 0 for node MARCKS_S170 and STAT3\n", + "i_search = 4\n", + "Looking for paths with length: 1 for node MARCKS_S170 and STAT3\n", + "i_search = 4\n", + "Looking for paths with length: 2 for node MARCKS_S170 and STAT3\n", + "i_search = 4\n", + "Looking for paths with length: 3 for node MARCKS_S170 and STAT3\n", + "i_search = 4\n", + "Looking for paths with length: 4 for node MARCKS_S170 and STAT3\n", + "looking for paths in the network with length: 0 for node MARCKS_S170 and CHEK2\n", + "looking for paths in the network with length: 1 for node MARCKS_S170 and CHEK2\n", + "looking for paths in the network with length: 2 for node MARCKS_S170 and CHEK2\n", + "looking for paths in the network with length: 3 for node MARCKS_S170 and CHEK2\n", + "looking for paths in the network with length: 4 for node MARCKS_S170 and CHEK2\n", + "looking for paths in the network with length: 5 for node MARCKS_S170 and CHEK2\n", + "looking for paths in the network with length: 6 for node MARCKS_S170 and CHEK2\n", + "looking for paths in the network with length: 7 for node MARCKS_S170 and CHEK2\n", + "looking for paths in the network with length: 8 for node MARCKS_S170 and CHEK2\n", + "looking for paths in the network with length: 9 for node MARCKS_S170 and CHEK2\n", + "looking for paths in the network with length: 10 for node MARCKS_S170 and CHEK2\n", + "i_search = 4\n", + "Looking for paths with length: 0 for node MARCKS_S170 and CHEK2\n", + "i_search = 4\n", + "Looking for paths with length: 1 for node MARCKS_S170 and CHEK2\n", + "i_search = 4\n", + "Looking for paths with length: 2 for node MARCKS_S170 and CHEK2\n", + "i_search = 4\n", + "Looking for paths with length: 3 for node MARCKS_S170 and CHEK2\n", + "i_search = 4\n", + "Looking for paths with length: 4 for node MARCKS_S170 and CHEK2\n", + "looking for paths in the network with length: 0 for node MARCKS_S170 and RELA\n", + "looking for paths in the network with length: 1 for node MARCKS_S170 and RELA\n", + "looking for paths in the network with length: 2 for node MARCKS_S170 and RELA\n", + "looking for paths in the network with length: 3 for node MARCKS_S170 and RELA\n", + "looking for paths in the network with length: 4 for node MARCKS_S170 and RELA\n", + "looking for paths in the network with length: 5 for node MARCKS_S170 and RELA\n", + "looking for paths in the network with length: 6 for node MARCKS_S170 and RELA\n", + "looking for paths in the network with length: 7 for node MARCKS_S170 and RELA\n", + "looking for paths in the network with length: 8 for node MARCKS_S170 and RELA\n", + "looking for paths in the network with length: 9 for node MARCKS_S170 and RELA\n", + "looking for paths in the network with length: 10 for node MARCKS_S170 and RELA\n", + "i_search = 4\n", + "Looking for paths with length: 0 for node MARCKS_S170 and RELA\n", + "i_search = 4\n", + "Looking for paths with length: 1 for node MARCKS_S170 and RELA\n", + "i_search = 4\n", + "Looking for paths with length: 2 for node MARCKS_S170 and RELA\n", + "i_search = 4\n", + "Looking for paths with length: 3 for node MARCKS_S170 and RELA\n", + "i_search = 4\n", + "Looking for paths with length: 4 for node MARCKS_S170 and RELA\n", + "looking for paths in the network with length: 0 for node MARCKS_S170 and MARCKS\n", + "looking for paths in the network with length: 1 for node MARCKS_S170 and MARCKS\n", + "looking for paths in the network with length: 2 for node MARCKS_S170 and MARCKS\n", + "looking for paths in the network with length: 3 for node MARCKS_S170 and MARCKS\n", + "looking for paths in the network with length: 4 for node MARCKS_S170 and MARCKS\n", + "looking for paths in the network with length: 5 for node MARCKS_S170 and MARCKS\n", + "looking for paths in the network with length: 6 for node MARCKS_S170 and MARCKS\n", + "looking for paths in the network with length: 7 for node MARCKS_S170 and MARCKS\n", + "looking for paths in the network with length: 8 for node MARCKS_S170 and MARCKS\n", + "looking for paths in the network with length: 9 for node MARCKS_S170 and MARCKS\n", + "looking for paths in the network with length: 10 for node MARCKS_S170 and MARCKS\n", + "i_search = 4\n", + "Looking for paths with length: 0 for node MARCKS_S170 and MARCKS\n", + "i_search = 4\n", + "Looking for paths with length: 1 for node MARCKS_S170 and MARCKS\n", + "i_search = 4\n", + "Looking for paths with length: 2 for node MARCKS_S170 and MARCKS\n", + "i_search = 4\n", + "Looking for paths with length: 3 for node MARCKS_S170 and MARCKS\n", + "i_search = 4\n", + "Looking for paths with length: 4 for node MARCKS_S170 and MARCKS\n", + "looking for paths in the network with length: 0 for node SMAD3 and TP53\n", + "looking for paths in the network with length: 1 for node SMAD3 and TP53\n", + "looking for paths in the network with length: 2 for node SMAD3 and TP53\n", + "looking for paths in the network with length: 3 for node SMAD3 and TP53\n", + "looking for paths in the network with length: 4 for node SMAD3 and TP53\n", + "looking for paths in the network with length: 5 for node SMAD3 and TP53\n", + "looking for paths in the network with length: 6 for node SMAD3 and TP53\n", + "looking for paths in the network with length: 7 for node SMAD3 and TP53\n", + "looking for paths in the network with length: 8 for node SMAD3 and TP53\n", + "looking for paths in the network with length: 9 for node SMAD3 and TP53\n", + "looking for paths in the network with length: 10 for node SMAD3 and TP53\n", + "i_search = 4\n", + "Looking for paths with length: 0 for node SMAD3 and TP53\n", + "i_search = 4\n", + "Looking for paths with length: 1 for node SMAD3 and TP53\n", + "i_search = 4\n", + "Looking for paths with length: 2 for node SMAD3 and TP53\n", + "i_search = 4\n", + "Looking for paths with length: 3 for node SMAD3 and TP53\n", + "i_search = 4\n", + "Looking for paths with length: 4 for node SMAD3 and TP53\n", + "looking for paths in the network with length: 0 for node SMAD3 and AKT1S1\n", + "looking for paths in the network with length: 1 for node SMAD3 and AKT1S1\n", + "looking for paths in the network with length: 2 for node SMAD3 and AKT1S1\n", + "looking for paths in the network with length: 3 for node SMAD3 and AKT1S1\n", + "looking for paths in the network with length: 4 for node SMAD3 and AKT1S1\n", + "looking for paths in the network with length: 5 for node SMAD3 and AKT1S1\n", + "looking for paths in the network with length: 6 for node SMAD3 and AKT1S1\n", + "looking for paths in the network with length: 7 for node SMAD3 and AKT1S1\n", + "looking for paths in the network with length: 8 for node SMAD3 and AKT1S1\n", + "looking for paths in the network with length: 9 for node SMAD3 and AKT1S1\n", + "looking for paths in the network with length: 10 for node SMAD3 and AKT1S1\n", + "i_search = 4\n", + "Looking for paths with length: 0 for node SMAD3 and AKT1S1\n", + "i_search = 4\n", + "Looking for paths with length: 1 for node SMAD3 and AKT1S1\n", + "i_search = 4\n", + "Looking for paths with length: 2 for node SMAD3 and AKT1S1\n", + "i_search = 4\n", + "Looking for paths with length: 3 for node SMAD3 and AKT1S1\n", + "i_search = 4\n", + "Looking for paths with length: 4 for node SMAD3 and AKT1S1\n", + "looking for paths in the network with length: 0 for node SMAD3 and GSK3B\n", + "looking for paths in the network with length: 1 for node SMAD3 and GSK3B\n", + "looking for paths in the network with length: 2 for node SMAD3 and GSK3B\n", + "looking for paths in the network with length: 3 for node SMAD3 and GSK3B\n", + "looking for paths in the network with length: 4 for node SMAD3 and GSK3B\n", + "looking for paths in the network with length: 5 for node SMAD3 and GSK3B\n", + "looking for paths in the network with length: 6 for node SMAD3 and GSK3B\n", + "looking for paths in the network with length: 7 for node SMAD3 and GSK3B\n", + "looking for paths in the network with length: 8 for node SMAD3 and GSK3B\n", + "looking for paths in the network with length: 9 for node SMAD3 and GSK3B\n", + "looking for paths in the network with length: 10 for node SMAD3 and GSK3B\n", + "i_search = 4\n", + "Looking for paths with length: 0 for node SMAD3 and GSK3B\n", + "i_search = 4\n", + "Looking for paths with length: 1 for node SMAD3 and GSK3B\n", + "i_search = 4\n", + "Looking for paths with length: 2 for node SMAD3 and GSK3B\n", + "i_search = 4\n", + "Looking for paths with length: 3 for node SMAD3 and GSK3B\n", + "i_search = 4\n", + "Looking for paths with length: 4 for node SMAD3 and GSK3B\n", + "looking for paths in the network with length: 0 for node SMAD3 and AKT1\n", + "looking for paths in the network with length: 1 for node SMAD3 and AKT1\n", + "looking for paths in the network with length: 2 for node SMAD3 and AKT1\n", + "looking for paths in the network with length: 3 for node SMAD3 and AKT1\n", + "looking for paths in the network with length: 4 for node SMAD3 and AKT1\n", + "looking for paths in the network with length: 5 for node SMAD3 and AKT1\n", + "looking for paths in the network with length: 6 for node SMAD3 and AKT1\n", + "looking for paths in the network with length: 7 for node SMAD3 and AKT1\n", + "looking for paths in the network with length: 8 for node SMAD3 and AKT1\n", + "looking for paths in the network with length: 9 for node SMAD3 and AKT1\n", + "looking for paths in the network with length: 10 for node SMAD3 and AKT1\n", + "i_search = 4\n", + "Looking for paths with length: 0 for node SMAD3 and AKT1\n", + "i_search = 4\n", + "Looking for paths with length: 1 for node SMAD3 and AKT1\n", + "i_search = 4\n", + "Looking for paths with length: 2 for node SMAD3 and AKT1\n", + "i_search = 4\n", + "Looking for paths with length: 3 for node SMAD3 and AKT1\n", + "i_search = 4\n", + "Looking for paths with length: 4 for node SMAD3 and AKT1\n", + "looking for paths in the network with length: 0 for node SMAD3 and HSPB1\n", + "looking for paths in the network with length: 1 for node SMAD3 and HSPB1\n", + "looking for paths in the network with length: 2 for node SMAD3 and HSPB1\n", + "looking for paths in the network with length: 3 for node SMAD3 and HSPB1\n", + "looking for paths in the network with length: 4 for node SMAD3 and HSPB1\n", + "looking for paths in the network with length: 5 for node SMAD3 and HSPB1\n", + "looking for paths in the network with length: 6 for node SMAD3 and HSPB1\n", + "looking for paths in the network with length: 7 for node SMAD3 and HSPB1\n", + "looking for paths in the network with length: 8 for node SMAD3 and HSPB1\n", + "looking for paths in the network with length: 9 for node SMAD3 and HSPB1\n", + "looking for paths in the network with length: 10 for node SMAD3 and HSPB1\n", + "i_search = 4\n", + "Looking for paths with length: 0 for node SMAD3 and HSPB1\n", + "i_search = 4\n", + "Looking for paths with length: 1 for node SMAD3 and HSPB1\n", + "i_search = 4\n", + "Looking for paths with length: 2 for node SMAD3 and HSPB1\n", + "i_search = 4\n", + "Looking for paths with length: 3 for node SMAD3 and HSPB1\n", + "i_search = 4\n", + "Looking for paths with length: 4 for node SMAD3 and HSPB1\n", + "looking for paths in the network with length: 0 for node SMAD3 and MAPK14\n", + "looking for paths in the network with length: 1 for node SMAD3 and MAPK14\n", + "looking for paths in the network with length: 2 for node SMAD3 and MAPK14\n", + "looking for paths in the network with length: 3 for node SMAD3 and MAPK14\n", + "looking for paths in the network with length: 4 for node SMAD3 and MAPK14\n", + "looking for paths in the network with length: 5 for node SMAD3 and MAPK14\n", + "looking for paths in the network with length: 6 for node SMAD3 and MAPK14\n", + "looking for paths in the network with length: 7 for node SMAD3 and MAPK14\n", + "looking for paths in the network with length: 8 for node SMAD3 and MAPK14\n", + "looking for paths in the network with length: 9 for node SMAD3 and MAPK14\n", + "looking for paths in the network with length: 10 for node SMAD3 and MAPK14\n", + "i_search = 4\n", + "Looking for paths with length: 0 for node SMAD3 and MAPK14\n", + "i_search = 4\n", + "Looking for paths with length: 1 for node SMAD3 and MAPK14\n", + "i_search = 4\n", + "Looking for paths with length: 2 for node SMAD3 and MAPK14\n", + "i_search = 4\n", + "Looking for paths with length: 3 for node SMAD3 and MAPK14\n", + "i_search = 4\n", + "Looking for paths with length: 4 for node SMAD3 and MAPK14\n", + "looking for paths in the network with length: 0 for node SMAD3 and MAP2K1\n", + "looking for paths in the network with length: 1 for node SMAD3 and MAP2K1\n", + "looking for paths in the network with length: 2 for node SMAD3 and MAP2K1\n", + "looking for paths in the network with length: 3 for node SMAD3 and MAP2K1\n", + "looking for paths in the network with length: 4 for node SMAD3 and MAP2K1\n", + "looking for paths in the network with length: 5 for node SMAD3 and MAP2K1\n", + "looking for paths in the network with length: 6 for node SMAD3 and MAP2K1\n", + "looking for paths in the network with length: 7 for node SMAD3 and MAP2K1\n", + "looking for paths in the network with length: 8 for node SMAD3 and MAP2K1\n", + "looking for paths in the network with length: 9 for node SMAD3 and MAP2K1\n", + "looking for paths in the network with length: 10 for node SMAD3 and MAP2K1\n", + "i_search = 4\n", + "Looking for paths with length: 0 for node SMAD3 and MAP2K1\n", + "i_search = 4\n", + "Looking for paths with length: 1 for node SMAD3 and MAP2K1\n", + "i_search = 4\n", + "Looking for paths with length: 2 for node SMAD3 and MAP2K1\n", + "i_search = 4\n", + "Looking for paths with length: 3 for node SMAD3 and MAP2K1\n", + "i_search = 4\n", + "Looking for paths with length: 4 for node SMAD3 and MAP2K1\n", + "looking for paths in the network with length: 0 for node SMAD3 and RPS6KA1\n", + "looking for paths in the network with length: 1 for node SMAD3 and RPS6KA1\n", + "looking for paths in the network with length: 2 for node SMAD3 and RPS6KA1\n", + "looking for paths in the network with length: 3 for node SMAD3 and RPS6KA1\n", + "looking for paths in the network with length: 4 for node SMAD3 and RPS6KA1\n", + "looking for paths in the network with length: 5 for node SMAD3 and RPS6KA1\n", + "looking for paths in the network with length: 6 for node SMAD3 and RPS6KA1\n", + "looking for paths in the network with length: 7 for node SMAD3 and RPS6KA1\n", + "looking for paths in the network with length: 8 for node SMAD3 and RPS6KA1\n", + "looking for paths in the network with length: 9 for node SMAD3 and RPS6KA1\n", + "looking for paths in the network with length: 10 for node SMAD3 and RPS6KA1\n", + "i_search = 4\n", + "Looking for paths with length: 0 for node SMAD3 and RPS6KA1\n", + "i_search = 4\n", + "Looking for paths with length: 1 for node SMAD3 and RPS6KA1\n", + "i_search = 4\n", + "Looking for paths with length: 2 for node SMAD3 and RPS6KA1\n", + "i_search = 4\n", + "Looking for paths with length: 3 for node SMAD3 and RPS6KA1\n", + "i_search = 4\n", + "Looking for paths with length: 4 for node SMAD3 and RPS6KA1\n", + "looking for paths in the network with length: 0 for node SMAD3 and CREB1\n", + "looking for paths in the network with length: 1 for node SMAD3 and CREB1\n", + "looking for paths in the network with length: 2 for node SMAD3 and CREB1\n", + "looking for paths in the network with length: 3 for node SMAD3 and CREB1\n", + "looking for paths in the network with length: 4 for node SMAD3 and CREB1\n", + "looking for paths in the network with length: 5 for node SMAD3 and CREB1\n", + "looking for paths in the network with length: 6 for node SMAD3 and CREB1\n", + "looking for paths in the network with length: 7 for node SMAD3 and CREB1\n", + "looking for paths in the network with length: 8 for node SMAD3 and CREB1\n", + "looking for paths in the network with length: 9 for node SMAD3 and CREB1\n", + "looking for paths in the network with length: 10 for node SMAD3 and CREB1\n", + "i_search = 4\n", + "Looking for paths with length: 0 for node SMAD3 and CREB1\n", + "i_search = 4\n", + "Looking for paths with length: 1 for node SMAD3 and CREB1\n", + "i_search = 4\n", + "Looking for paths with length: 2 for node SMAD3 and CREB1\n", + "i_search = 4\n", + "Looking for paths with length: 3 for node SMAD3 and CREB1\n", + "i_search = 4\n", + "Looking for paths with length: 4 for node SMAD3 and CREB1\n", + "looking for paths in the network with length: 0 for node SMAD3 and NFKBIA\n", + "looking for paths in the network with length: 1 for node SMAD3 and NFKBIA\n", + "looking for paths in the network with length: 2 for node SMAD3 and NFKBIA\n", + "looking for paths in the network with length: 3 for node SMAD3 and NFKBIA\n", + "looking for paths in the network with length: 4 for node SMAD3 and NFKBIA\n", + "looking for paths in the network with length: 5 for node SMAD3 and NFKBIA\n", + "looking for paths in the network with length: 6 for node SMAD3 and NFKBIA\n", + "looking for paths in the network with length: 7 for node SMAD3 and NFKBIA\n", + "looking for paths in the network with length: 8 for node SMAD3 and NFKBIA\n", + "looking for paths in the network with length: 9 for node SMAD3 and NFKBIA\n", + "looking for paths in the network with length: 10 for node SMAD3 and NFKBIA\n", + "i_search = 4\n", + "Looking for paths with length: 0 for node SMAD3 and NFKBIA\n", + "i_search = 4\n", + "Looking for paths with length: 1 for node SMAD3 and NFKBIA\n", + "i_search = 4\n", + "Looking for paths with length: 2 for node SMAD3 and NFKBIA\n", + "i_search = 4\n", + "Looking for paths with length: 3 for node SMAD3 and NFKBIA\n", + "i_search = 4\n", + "Looking for paths with length: 4 for node SMAD3 and NFKBIA\n", + "looking for paths in the network with length: 0 for node SMAD3 and MTOR\n", + "looking for paths in the network with length: 1 for node SMAD3 and MTOR\n", + "looking for paths in the network with length: 2 for node SMAD3 and MTOR\n", + "looking for paths in the network with length: 3 for node SMAD3 and MTOR\n", + "looking for paths in the network with length: 4 for node SMAD3 and MTOR\n", + "looking for paths in the network with length: 5 for node SMAD3 and MTOR\n", + "looking for paths in the network with length: 6 for node SMAD3 and MTOR\n", + "looking for paths in the network with length: 7 for node SMAD3 and MTOR\n", + "looking for paths in the network with length: 8 for node SMAD3 and MTOR\n", + "looking for paths in the network with length: 9 for node SMAD3 and MTOR\n", + "looking for paths in the network with length: 10 for node SMAD3 and MTOR\n", + "i_search = 4\n", + "Looking for paths with length: 0 for node SMAD3 and MTOR\n", + "i_search = 4\n", + "Looking for paths with length: 1 for node SMAD3 and MTOR\n", + "i_search = 4\n", + "Looking for paths with length: 2 for node SMAD3 and MTOR\n", + "i_search = 4\n", + "Looking for paths with length: 3 for node SMAD3 and MTOR\n", + "i_search = 4\n", + "Looking for paths with length: 4 for node SMAD3 and MTOR\n", + "looking for paths in the network with length: 0 for node SMAD3 and JUN\n", + "looking for paths in the network with length: 1 for node SMAD3 and JUN\n", + "looking for paths in the network with length: 2 for node SMAD3 and JUN\n", + "looking for paths in the network with length: 3 for node SMAD3 and JUN\n", + "looking for paths in the network with length: 4 for node SMAD3 and JUN\n", + "looking for paths in the network with length: 5 for node SMAD3 and JUN\n", + "looking for paths in the network with length: 6 for node SMAD3 and JUN\n", + "looking for paths in the network with length: 7 for node SMAD3 and JUN\n", + "looking for paths in the network with length: 8 for node SMAD3 and JUN\n", + "looking for paths in the network with length: 9 for node SMAD3 and JUN\n", + "looking for paths in the network with length: 10 for node SMAD3 and JUN\n", + "i_search = 4\n", + "Looking for paths with length: 0 for node SMAD3 and JUN\n", + "i_search = 4\n", + "Looking for paths with length: 1 for node SMAD3 and JUN\n", + "i_search = 4\n", + "Looking for paths with length: 2 for node SMAD3 and JUN\n", + "i_search = 4\n", + "Looking for paths with length: 3 for node SMAD3 and JUN\n", + "i_search = 4\n", + "Looking for paths with length: 4 for node SMAD3 and JUN\n", + "looking for paths in the network with length: 0 for node SMAD3 and EGFR\n", + "looking for paths in the network with length: 1 for node SMAD3 and EGFR\n", + "looking for paths in the network with length: 2 for node SMAD3 and EGFR\n", + "looking for paths in the network with length: 3 for node SMAD3 and EGFR\n", + "looking for paths in the network with length: 4 for node SMAD3 and EGFR\n", + "looking for paths in the network with length: 5 for node SMAD3 and EGFR\n", + "looking for paths in the network with length: 6 for node SMAD3 and EGFR\n", + "looking for paths in the network with length: 7 for node SMAD3 and EGFR\n", + "looking for paths in the network with length: 8 for node SMAD3 and EGFR\n", + "looking for paths in the network with length: 9 for node SMAD3 and EGFR\n", + "looking for paths in the network with length: 10 for node SMAD3 and EGFR\n", + "i_search = 4\n", + "Looking for paths with length: 0 for node SMAD3 and EGFR\n", + "i_search = 4\n", + "Looking for paths with length: 1 for node SMAD3 and EGFR\n", + "i_search = 4\n", + "Looking for paths with length: 2 for node SMAD3 and EGFR\n", + "i_search = 4\n", + "Looking for paths with length: 3 for node SMAD3 and EGFR\n", + "i_search = 4\n", + "Looking for paths with length: 4 for node SMAD3 and EGFR\n", + "looking for paths in the network with length: 0 for node SMAD3 and MAPK3\n", + "looking for paths in the network with length: 1 for node SMAD3 and MAPK3\n", + "looking for paths in the network with length: 2 for node SMAD3 and MAPK3\n", + "looking for paths in the network with length: 3 for node SMAD3 and MAPK3\n", + "looking for paths in the network with length: 4 for node SMAD3 and MAPK3\n", + "looking for paths in the network with length: 5 for node SMAD3 and MAPK3\n", + "looking for paths in the network with length: 6 for node SMAD3 and MAPK3\n", + "looking for paths in the network with length: 7 for node SMAD3 and MAPK3\n", + "looking for paths in the network with length: 8 for node SMAD3 and MAPK3\n", + "looking for paths in the network with length: 9 for node SMAD3 and MAPK3\n", + "looking for paths in the network with length: 10 for node SMAD3 and MAPK3\n", + "i_search = 4\n", + "Looking for paths with length: 0 for node SMAD3 and MAPK3\n", + "i_search = 4\n", + "Looking for paths with length: 1 for node SMAD3 and MAPK3\n", + "i_search = 4\n", + "Looking for paths with length: 2 for node SMAD3 and MAPK3\n", + "i_search = 4\n", + "Looking for paths with length: 3 for node SMAD3 and MAPK3\n", + "i_search = 4\n", + "Looking for paths with length: 4 for node SMAD3 and MAPK3\n", + "looking for paths in the network with length: 0 for node SMAD3 and PTPN11\n", + "looking for paths in the network with length: 1 for node SMAD3 and PTPN11\n", + "looking for paths in the network with length: 2 for node SMAD3 and PTPN11\n", + "looking for paths in the network with length: 3 for node SMAD3 and PTPN11\n", + "looking for paths in the network with length: 4 for node SMAD3 and PTPN11\n", + "looking for paths in the network with length: 5 for node SMAD3 and PTPN11\n", + "looking for paths in the network with length: 6 for node SMAD3 and PTPN11\n", + "looking for paths in the network with length: 7 for node SMAD3 and PTPN11\n", + "looking for paths in the network with length: 8 for node SMAD3 and PTPN11\n", + "looking for paths in the network with length: 9 for node SMAD3 and PTPN11\n", + "looking for paths in the network with length: 10 for node SMAD3 and PTPN11\n", + "i_search = 4\n", + "Looking for paths with length: 0 for node SMAD3 and PTPN11\n", + "i_search = 4\n", + "Looking for paths with length: 1 for node SMAD3 and PTPN11\n", + "i_search = 4\n", + "Looking for paths with length: 2 for node SMAD3 and PTPN11\n", + "i_search = 4\n", + "Looking for paths with length: 3 for node SMAD3 and PTPN11\n", + "i_search = 4\n", + "Looking for paths with length: 4 for node SMAD3 and PTPN11\n", + "looking for paths in the network with length: 0 for node SMAD3 and STAT3\n", + "looking for paths in the network with length: 1 for node SMAD3 and STAT3\n", + "looking for paths in the network with length: 2 for node SMAD3 and STAT3\n", + "looking for paths in the network with length: 3 for node SMAD3 and STAT3\n", + "looking for paths in the network with length: 4 for node SMAD3 and STAT3\n", + "looking for paths in the network with length: 5 for node SMAD3 and STAT3\n", + "looking for paths in the network with length: 6 for node SMAD3 and STAT3\n", + "looking for paths in the network with length: 7 for node SMAD3 and STAT3\n", + "looking for paths in the network with length: 8 for node SMAD3 and STAT3\n", + "looking for paths in the network with length: 9 for node SMAD3 and STAT3\n", + "looking for paths in the network with length: 10 for node SMAD3 and STAT3\n", + "i_search = 4\n", + "Looking for paths with length: 0 for node SMAD3 and STAT3\n", + "i_search = 4\n", + "Looking for paths with length: 1 for node SMAD3 and STAT3\n", + "i_search = 4\n", + "Looking for paths with length: 2 for node SMAD3 and STAT3\n", + "i_search = 4\n", + "Looking for paths with length: 3 for node SMAD3 and STAT3\n", + "i_search = 4\n", + "Looking for paths with length: 4 for node SMAD3 and STAT3\n", + "looking for paths in the network with length: 0 for node SMAD3 and CHEK2\n", + "looking for paths in the network with length: 1 for node SMAD3 and CHEK2\n", + "looking for paths in the network with length: 2 for node SMAD3 and CHEK2\n", + "looking for paths in the network with length: 3 for node SMAD3 and CHEK2\n", + "looking for paths in the network with length: 4 for node SMAD3 and CHEK2\n", + "looking for paths in the network with length: 5 for node SMAD3 and CHEK2\n", + "looking for paths in the network with length: 6 for node SMAD3 and CHEK2\n", + "looking for paths in the network with length: 7 for node SMAD3 and CHEK2\n", + "looking for paths in the network with length: 8 for node SMAD3 and CHEK2\n", + "looking for paths in the network with length: 9 for node SMAD3 and CHEK2\n", + "looking for paths in the network with length: 10 for node SMAD3 and CHEK2\n", + "i_search = 4\n", + "Looking for paths with length: 0 for node SMAD3 and CHEK2\n", + "i_search = 4\n", + "Looking for paths with length: 1 for node SMAD3 and CHEK2\n", + "i_search = 4\n", + "Looking for paths with length: 2 for node SMAD3 and CHEK2\n", + "i_search = 4\n", + "Looking for paths with length: 3 for node SMAD3 and CHEK2\n", + "i_search = 4\n", + "Looking for paths with length: 4 for node SMAD3 and CHEK2\n", + "looking for paths in the network with length: 0 for node SMAD3 and RELA\n", + "looking for paths in the network with length: 1 for node SMAD3 and RELA\n", + "looking for paths in the network with length: 2 for node SMAD3 and RELA\n", + "looking for paths in the network with length: 3 for node SMAD3 and RELA\n", + "looking for paths in the network with length: 4 for node SMAD3 and RELA\n", + "looking for paths in the network with length: 5 for node SMAD3 and RELA\n", + "looking for paths in the network with length: 6 for node SMAD3 and RELA\n", + "looking for paths in the network with length: 7 for node SMAD3 and RELA\n", + "looking for paths in the network with length: 8 for node SMAD3 and RELA\n", + "looking for paths in the network with length: 9 for node SMAD3 and RELA\n", + "looking for paths in the network with length: 10 for node SMAD3 and RELA\n", + "i_search = 4\n", + "Looking for paths with length: 0 for node SMAD3 and RELA\n", + "i_search = 4\n", + "Looking for paths with length: 1 for node SMAD3 and RELA\n", + "i_search = 4\n", + "Looking for paths with length: 2 for node SMAD3 and RELA\n", + "i_search = 4\n", + "Looking for paths with length: 3 for node SMAD3 and RELA\n", + "i_search = 4\n", + "Looking for paths with length: 4 for node SMAD3 and RELA\n", + "looking for paths in the network with length: 0 for node SMAD3 and MARCKS\n", + "looking for paths in the network with length: 1 for node SMAD3 and MARCKS\n", + "looking for paths in the network with length: 2 for node SMAD3 and MARCKS\n", + "looking for paths in the network with length: 3 for node SMAD3 and MARCKS\n", + "looking for paths in the network with length: 4 for node SMAD3 and MARCKS\n", + "looking for paths in the network with length: 5 for node SMAD3 and MARCKS\n", + "looking for paths in the network with length: 6 for node SMAD3 and MARCKS\n", + "looking for paths in the network with length: 7 for node SMAD3 and MARCKS\n", + "looking for paths in the network with length: 8 for node SMAD3 and MARCKS\n", + "looking for paths in the network with length: 9 for node SMAD3 and MARCKS\n", + "looking for paths in the network with length: 10 for node SMAD3 and MARCKS\n", + "i_search = 4\n", + "Looking for paths with length: 0 for node SMAD3 and MARCKS\n", + "i_search = 4\n", + "Looking for paths with length: 1 for node SMAD3 and MARCKS\n", + "i_search = 4\n", + "Looking for paths with length: 2 for node SMAD3 and MARCKS\n", + "i_search = 4\n", + "Looking for paths with length: 3 for node SMAD3 and MARCKS\n", + "i_search = 4\n", + "Looking for paths with length: 4 for node SMAD3 and MARCKS\n", + "looking for paths in the network with length: 0 for node TP53 and AKT1S1\n", + "looking for paths in the network with length: 1 for node TP53 and AKT1S1\n", + "looking for paths in the network with length: 2 for node TP53 and AKT1S1\n", + "looking for paths in the network with length: 3 for node TP53 and AKT1S1\n", + "looking for paths in the network with length: 4 for node TP53 and AKT1S1\n", + "looking for paths in the network with length: 5 for node TP53 and AKT1S1\n", + "looking for paths in the network with length: 6 for node TP53 and AKT1S1\n", + "looking for paths in the network with length: 7 for node TP53 and AKT1S1\n", + "looking for paths in the network with length: 8 for node TP53 and AKT1S1\n", + "looking for paths in the network with length: 9 for node TP53 and AKT1S1\n", + "looking for paths in the network with length: 10 for node TP53 and AKT1S1\n", + "i_search = 4\n", + "Looking for paths with length: 0 for node TP53 and AKT1S1\n", + "i_search = 4\n", + "Looking for paths with length: 1 for node TP53 and AKT1S1\n", + "i_search = 4\n", + "Looking for paths with length: 2 for node TP53 and AKT1S1\n", + "i_search = 4\n", + "Looking for paths with length: 3 for node TP53 and AKT1S1\n", + "i_search = 4\n", + "Looking for paths with length: 4 for node TP53 and AKT1S1\n", + "looking for paths in the network with length: 0 for node TP53 and GSK3B\n", + "looking for paths in the network with length: 1 for node TP53 and GSK3B\n", + "looking for paths in the network with length: 2 for node TP53 and GSK3B\n", + "looking for paths in the network with length: 3 for node TP53 and GSK3B\n", + "looking for paths in the network with length: 4 for node TP53 and GSK3B\n", + "looking for paths in the network with length: 5 for node TP53 and GSK3B\n", + "looking for paths in the network with length: 6 for node TP53 and GSK3B\n", + "looking for paths in the network with length: 7 for node TP53 and GSK3B\n", + "looking for paths in the network with length: 8 for node TP53 and GSK3B\n", + "looking for paths in the network with length: 9 for node TP53 and GSK3B\n", + "looking for paths in the network with length: 10 for node TP53 and GSK3B\n", + "i_search = 4\n", + "Looking for paths with length: 0 for node TP53 and GSK3B\n", + "i_search = 4\n", + "Looking for paths with length: 1 for node TP53 and GSK3B\n", + "i_search = 4\n", + "Looking for paths with length: 2 for node TP53 and GSK3B\n", + "i_search = 4\n", + "Looking for paths with length: 3 for node TP53 and GSK3B\n", + "i_search = 4\n", + "Looking for paths with length: 4 for node TP53 and GSK3B\n", + "looking for paths in the network with length: 0 for node TP53 and AKT1\n", + "looking for paths in the network with length: 1 for node TP53 and AKT1\n", + "looking for paths in the network with length: 2 for node TP53 and AKT1\n", + "looking for paths in the network with length: 3 for node TP53 and AKT1\n", + "looking for paths in the network with length: 4 for node TP53 and AKT1\n", + "looking for paths in the network with length: 5 for node TP53 and AKT1\n", + "looking for paths in the network with length: 6 for node TP53 and AKT1\n", + "looking for paths in the network with length: 7 for node TP53 and AKT1\n", + "looking for paths in the network with length: 8 for node TP53 and AKT1\n", + "looking for paths in the network with length: 9 for node TP53 and AKT1\n", + "looking for paths in the network with length: 10 for node TP53 and AKT1\n", + "i_search = 4\n", + "Looking for paths with length: 0 for node TP53 and AKT1\n", + "i_search = 4\n", + "Looking for paths with length: 1 for node TP53 and AKT1\n", + "i_search = 4\n", + "Looking for paths with length: 2 for node TP53 and AKT1\n", + "i_search = 4\n", + "Looking for paths with length: 3 for node TP53 and AKT1\n", + "i_search = 4\n", + "Looking for paths with length: 4 for node TP53 and AKT1\n", + "looking for paths in the network with length: 0 for node TP53 and HSPB1\n", + "looking for paths in the network with length: 1 for node TP53 and HSPB1\n", + "looking for paths in the network with length: 2 for node TP53 and HSPB1\n", + "looking for paths in the network with length: 3 for node TP53 and HSPB1\n", + "looking for paths in the network with length: 4 for node TP53 and HSPB1\n", + "looking for paths in the network with length: 5 for node TP53 and HSPB1\n", + "looking for paths in the network with length: 6 for node TP53 and HSPB1\n", + "looking for paths in the network with length: 7 for node TP53 and HSPB1\n", + "looking for paths in the network with length: 8 for node TP53 and HSPB1\n", + "looking for paths in the network with length: 9 for node TP53 and HSPB1\n", + "looking for paths in the network with length: 10 for node TP53 and HSPB1\n", + "i_search = 4\n", + "Looking for paths with length: 0 for node TP53 and HSPB1\n", + "i_search = 4\n", + "Looking for paths with length: 1 for node TP53 and HSPB1\n", + "i_search = 4\n", + "Looking for paths with length: 2 for node TP53 and HSPB1\n", + "i_search = 4\n", + "Looking for paths with length: 3 for node TP53 and HSPB1\n", + "i_search = 4\n", + "Looking for paths with length: 4 for node TP53 and HSPB1\n", + "looking for paths in the network with length: 0 for node TP53 and MAPK14\n", + "looking for paths in the network with length: 1 for node TP53 and MAPK14\n", + "looking for paths in the network with length: 2 for node TP53 and MAPK14\n", + "looking for paths in the network with length: 3 for node TP53 and MAPK14\n", + "looking for paths in the network with length: 4 for node TP53 and MAPK14\n", + "looking for paths in the network with length: 5 for node TP53 and MAPK14\n", + "looking for paths in the network with length: 6 for node TP53 and MAPK14\n", + "looking for paths in the network with length: 7 for node TP53 and MAPK14\n", + "looking for paths in the network with length: 8 for node TP53 and MAPK14\n", + "looking for paths in the network with length: 9 for node TP53 and MAPK14\n", + "looking for paths in the network with length: 10 for node TP53 and MAPK14\n", + "i_search = 4\n", + "Looking for paths with length: 0 for node TP53 and MAPK14\n", + "i_search = 4\n", + "Looking for paths with length: 1 for node TP53 and MAPK14\n", + "i_search = 4\n", + "Looking for paths with length: 2 for node TP53 and MAPK14\n", + "i_search = 4\n", + "Looking for paths with length: 3 for node TP53 and MAPK14\n", + "i_search = 4\n", + "Looking for paths with length: 4 for node TP53 and MAPK14\n", + "looking for paths in the network with length: 0 for node TP53 and MAP2K1\n", + "looking for paths in the network with length: 1 for node TP53 and MAP2K1\n", + "looking for paths in the network with length: 2 for node TP53 and MAP2K1\n", + "looking for paths in the network with length: 3 for node TP53 and MAP2K1\n", + "looking for paths in the network with length: 4 for node TP53 and MAP2K1\n", + "looking for paths in the network with length: 5 for node TP53 and MAP2K1\n", + "looking for paths in the network with length: 6 for node TP53 and MAP2K1\n", + "looking for paths in the network with length: 7 for node TP53 and MAP2K1\n", + "looking for paths in the network with length: 8 for node TP53 and MAP2K1\n", + "looking for paths in the network with length: 9 for node TP53 and MAP2K1\n", + "looking for paths in the network with length: 10 for node TP53 and MAP2K1\n", + "i_search = 4\n", + "Looking for paths with length: 0 for node TP53 and MAP2K1\n", + "i_search = 4\n", + "Looking for paths with length: 1 for node TP53 and MAP2K1\n", + "i_search = 4\n", + "Looking for paths with length: 2 for node TP53 and MAP2K1\n", + "i_search = 4\n", + "Looking for paths with length: 3 for node TP53 and MAP2K1\n", + "i_search = 4\n", + "Looking for paths with length: 4 for node TP53 and MAP2K1\n", + "looking for paths in the network with length: 0 for node TP53 and RPS6KA1\n", + "looking for paths in the network with length: 1 for node TP53 and RPS6KA1\n", + "looking for paths in the network with length: 2 for node TP53 and RPS6KA1\n", + "looking for paths in the network with length: 3 for node TP53 and RPS6KA1\n", + "looking for paths in the network with length: 4 for node TP53 and RPS6KA1\n", + "looking for paths in the network with length: 5 for node TP53 and RPS6KA1\n", + "looking for paths in the network with length: 6 for node TP53 and RPS6KA1\n", + "looking for paths in the network with length: 7 for node TP53 and RPS6KA1\n", + "looking for paths in the network with length: 8 for node TP53 and RPS6KA1\n", + "looking for paths in the network with length: 9 for node TP53 and RPS6KA1\n", + "looking for paths in the network with length: 10 for node TP53 and RPS6KA1\n", + "i_search = 4\n", + "Looking for paths with length: 0 for node TP53 and RPS6KA1\n", + "i_search = 4\n", + "Looking for paths with length: 1 for node TP53 and RPS6KA1\n", + "i_search = 4\n", + "Looking for paths with length: 2 for node TP53 and RPS6KA1\n", + "i_search = 4\n", + "Looking for paths with length: 3 for node TP53 and RPS6KA1\n", + "i_search = 4\n", + "Looking for paths with length: 4 for node TP53 and RPS6KA1\n", + "looking for paths in the network with length: 0 for node TP53 and CREB1\n", + "looking for paths in the network with length: 1 for node TP53 and CREB1\n", + "looking for paths in the network with length: 2 for node TP53 and CREB1\n", + "looking for paths in the network with length: 3 for node TP53 and CREB1\n", + "looking for paths in the network with length: 4 for node TP53 and CREB1\n", + "looking for paths in the network with length: 5 for node TP53 and CREB1\n", + "looking for paths in the network with length: 6 for node TP53 and CREB1\n", + "looking for paths in the network with length: 7 for node TP53 and CREB1\n", + "looking for paths in the network with length: 8 for node TP53 and CREB1\n", + "looking for paths in the network with length: 9 for node TP53 and CREB1\n", + "looking for paths in the network with length: 10 for node TP53 and CREB1\n", + "i_search = 4\n", + "Looking for paths with length: 0 for node TP53 and CREB1\n", + "i_search = 4\n", + "Looking for paths with length: 1 for node TP53 and CREB1\n", + "i_search = 4\n", + "Looking for paths with length: 2 for node TP53 and CREB1\n", + "i_search = 4\n", + "Looking for paths with length: 3 for node TP53 and CREB1\n", + "i_search = 4\n", + "Looking for paths with length: 4 for node TP53 and CREB1\n", + "looking for paths in the network with length: 0 for node TP53 and NFKBIA\n", + "looking for paths in the network with length: 1 for node TP53 and NFKBIA\n", + "looking for paths in the network with length: 2 for node TP53 and NFKBIA\n", + "looking for paths in the network with length: 3 for node TP53 and NFKBIA\n", + "looking for paths in the network with length: 4 for node TP53 and NFKBIA\n", + "looking for paths in the network with length: 5 for node TP53 and NFKBIA\n", + "looking for paths in the network with length: 6 for node TP53 and NFKBIA\n", + "looking for paths in the network with length: 7 for node TP53 and NFKBIA\n", + "looking for paths in the network with length: 8 for node TP53 and NFKBIA\n", + "looking for paths in the network with length: 9 for node TP53 and NFKBIA\n", + "looking for paths in the network with length: 10 for node TP53 and NFKBIA\n", + "i_search = 4\n", + "Looking for paths with length: 0 for node TP53 and NFKBIA\n", + "i_search = 4\n", + "Looking for paths with length: 1 for node TP53 and NFKBIA\n", + "i_search = 4\n", + "Looking for paths with length: 2 for node TP53 and NFKBIA\n", + "i_search = 4\n", + "Looking for paths with length: 3 for node TP53 and NFKBIA\n", + "i_search = 4\n", + "Looking for paths with length: 4 for node TP53 and NFKBIA\n", + "looking for paths in the network with length: 0 for node TP53 and MTOR\n", + "looking for paths in the network with length: 1 for node TP53 and MTOR\n", + "looking for paths in the network with length: 2 for node TP53 and MTOR\n", + "looking for paths in the network with length: 3 for node TP53 and MTOR\n", + "looking for paths in the network with length: 4 for node TP53 and MTOR\n", + "looking for paths in the network with length: 5 for node TP53 and MTOR\n", + "looking for paths in the network with length: 6 for node TP53 and MTOR\n", + "looking for paths in the network with length: 7 for node TP53 and MTOR\n", + "looking for paths in the network with length: 8 for node TP53 and MTOR\n", + "looking for paths in the network with length: 9 for node TP53 and MTOR\n", + "looking for paths in the network with length: 10 for node TP53 and MTOR\n", + "i_search = 4\n", + "Looking for paths with length: 0 for node TP53 and MTOR\n", + "i_search = 4\n", + "Looking for paths with length: 1 for node TP53 and MTOR\n", + "i_search = 4\n", + "Looking for paths with length: 2 for node TP53 and MTOR\n", + "i_search = 4\n", + "Looking for paths with length: 3 for node TP53 and MTOR\n", + "i_search = 4\n", + "Looking for paths with length: 4 for node TP53 and MTOR\n", + "looking for paths in the network with length: 0 for node TP53 and JUN\n", + "looking for paths in the network with length: 1 for node TP53 and JUN\n", + "looking for paths in the network with length: 2 for node TP53 and JUN\n", + "looking for paths in the network with length: 3 for node TP53 and JUN\n", + "looking for paths in the network with length: 4 for node TP53 and JUN\n", + "looking for paths in the network with length: 5 for node TP53 and JUN\n", + "looking for paths in the network with length: 6 for node TP53 and JUN\n", + "looking for paths in the network with length: 7 for node TP53 and JUN\n", + "looking for paths in the network with length: 8 for node TP53 and JUN\n", + "looking for paths in the network with length: 9 for node TP53 and JUN\n", + "looking for paths in the network with length: 10 for node TP53 and JUN\n", + "i_search = 4\n", + "Looking for paths with length: 0 for node TP53 and JUN\n", + "i_search = 4\n", + "Looking for paths with length: 1 for node TP53 and JUN\n", + "i_search = 4\n", + "Looking for paths with length: 2 for node TP53 and JUN\n", + "i_search = 4\n", + "Looking for paths with length: 3 for node TP53 and JUN\n", + "i_search = 4\n", + "Looking for paths with length: 4 for node TP53 and JUN\n", + "looking for paths in the network with length: 0 for node TP53 and EGFR\n", + "looking for paths in the network with length: 1 for node TP53 and EGFR\n", + "looking for paths in the network with length: 2 for node TP53 and EGFR\n", + "looking for paths in the network with length: 3 for node TP53 and EGFR\n", + "looking for paths in the network with length: 4 for node TP53 and EGFR\n", + "looking for paths in the network with length: 5 for node TP53 and EGFR\n", + "looking for paths in the network with length: 6 for node TP53 and EGFR\n", + "looking for paths in the network with length: 7 for node TP53 and EGFR\n", + "looking for paths in the network with length: 8 for node TP53 and EGFR\n", + "looking for paths in the network with length: 9 for node TP53 and EGFR\n", + "looking for paths in the network with length: 10 for node TP53 and EGFR\n", + "i_search = 4\n", + "Looking for paths with length: 0 for node TP53 and EGFR\n", + "i_search = 4\n", + "Looking for paths with length: 1 for node TP53 and EGFR\n", + "i_search = 4\n", + "Looking for paths with length: 2 for node TP53 and EGFR\n", + "i_search = 4\n", + "Looking for paths with length: 3 for node TP53 and EGFR\n", + "i_search = 4\n", + "Looking for paths with length: 4 for node TP53 and EGFR\n", + "looking for paths in the network with length: 0 for node TP53 and MAPK3\n", + "looking for paths in the network with length: 1 for node TP53 and MAPK3\n", + "looking for paths in the network with length: 2 for node TP53 and MAPK3\n", + "looking for paths in the network with length: 3 for node TP53 and MAPK3\n", + "looking for paths in the network with length: 4 for node TP53 and MAPK3\n", + "looking for paths in the network with length: 5 for node TP53 and MAPK3\n", + "looking for paths in the network with length: 6 for node TP53 and MAPK3\n", + "looking for paths in the network with length: 7 for node TP53 and MAPK3\n", + "looking for paths in the network with length: 8 for node TP53 and MAPK3\n", + "looking for paths in the network with length: 9 for node TP53 and MAPK3\n", + "looking for paths in the network with length: 10 for node TP53 and MAPK3\n", + "i_search = 4\n", + "Looking for paths with length: 0 for node TP53 and MAPK3\n", + "i_search = 4\n", + "Looking for paths with length: 1 for node TP53 and MAPK3\n", + "i_search = 4\n", + "Looking for paths with length: 2 for node TP53 and MAPK3\n", + "i_search = 4\n", + "Looking for paths with length: 3 for node TP53 and MAPK3\n", + "i_search = 4\n", + "Looking for paths with length: 4 for node TP53 and MAPK3\n", + "looking for paths in the network with length: 0 for node TP53 and PTPN11\n", + "looking for paths in the network with length: 1 for node TP53 and PTPN11\n", + "looking for paths in the network with length: 2 for node TP53 and PTPN11\n", + "looking for paths in the network with length: 3 for node TP53 and PTPN11\n", + "looking for paths in the network with length: 4 for node TP53 and PTPN11\n", + "looking for paths in the network with length: 5 for node TP53 and PTPN11\n", + "looking for paths in the network with length: 6 for node TP53 and PTPN11\n", + "looking for paths in the network with length: 7 for node TP53 and PTPN11\n", + "looking for paths in the network with length: 8 for node TP53 and PTPN11\n", + "looking for paths in the network with length: 9 for node TP53 and PTPN11\n", + "looking for paths in the network with length: 10 for node TP53 and PTPN11\n", + "i_search = 4\n", + "Looking for paths with length: 0 for node TP53 and PTPN11\n", + "i_search = 4\n", + "Looking for paths with length: 1 for node TP53 and PTPN11\n", + "i_search = 4\n", + "Looking for paths with length: 2 for node TP53 and PTPN11\n", + "i_search = 4\n", + "Looking for paths with length: 3 for node TP53 and PTPN11\n", + "i_search = 4\n", + "Looking for paths with length: 4 for node TP53 and PTPN11\n", + "looking for paths in the network with length: 0 for node TP53 and STAT3\n", + "looking for paths in the network with length: 1 for node TP53 and STAT3\n", + "looking for paths in the network with length: 2 for node TP53 and STAT3\n", + "looking for paths in the network with length: 3 for node TP53 and STAT3\n", + "looking for paths in the network with length: 4 for node TP53 and STAT3\n", + "looking for paths in the network with length: 5 for node TP53 and STAT3\n", + "looking for paths in the network with length: 6 for node TP53 and STAT3\n", + "looking for paths in the network with length: 7 for node TP53 and STAT3\n", + "looking for paths in the network with length: 8 for node TP53 and STAT3\n", + "looking for paths in the network with length: 9 for node TP53 and STAT3\n", + "looking for paths in the network with length: 10 for node TP53 and STAT3\n", + "i_search = 4\n", + "Looking for paths with length: 0 for node TP53 and STAT3\n", + "i_search = 4\n", + "Looking for paths with length: 1 for node TP53 and STAT3\n", + "i_search = 4\n", + "Looking for paths with length: 2 for node TP53 and STAT3\n", + "i_search = 4\n", + "Looking for paths with length: 3 for node TP53 and STAT3\n", + "i_search = 4\n", + "Looking for paths with length: 4 for node TP53 and STAT3\n", + "looking for paths in the network with length: 0 for node TP53 and CHEK2\n", + "looking for paths in the network with length: 1 for node TP53 and CHEK2\n", + "looking for paths in the network with length: 2 for node TP53 and CHEK2\n", + "looking for paths in the network with length: 3 for node TP53 and CHEK2\n", + "looking for paths in the network with length: 4 for node TP53 and CHEK2\n", + "looking for paths in the network with length: 5 for node TP53 and CHEK2\n", + "looking for paths in the network with length: 6 for node TP53 and CHEK2\n", + "looking for paths in the network with length: 7 for node TP53 and CHEK2\n", + "looking for paths in the network with length: 8 for node TP53 and CHEK2\n", + "looking for paths in the network with length: 9 for node TP53 and CHEK2\n", + "looking for paths in the network with length: 10 for node TP53 and CHEK2\n", + "i_search = 4\n", + "Looking for paths with length: 0 for node TP53 and CHEK2\n", + "i_search = 4\n", + "Looking for paths with length: 1 for node TP53 and CHEK2\n", + "i_search = 4\n", + "Looking for paths with length: 2 for node TP53 and CHEK2\n", + "i_search = 4\n", + "Looking for paths with length: 3 for node TP53 and CHEK2\n", + "i_search = 4\n", + "Looking for paths with length: 4 for node TP53 and CHEK2\n", + "looking for paths in the network with length: 0 for node TP53 and RELA\n", + "looking for paths in the network with length: 1 for node TP53 and RELA\n", + "looking for paths in the network with length: 2 for node TP53 and RELA\n", + "looking for paths in the network with length: 3 for node TP53 and RELA\n", + "looking for paths in the network with length: 4 for node TP53 and RELA\n", + "looking for paths in the network with length: 5 for node TP53 and RELA\n", + "looking for paths in the network with length: 6 for node TP53 and RELA\n", + "looking for paths in the network with length: 7 for node TP53 and RELA\n", + "looking for paths in the network with length: 8 for node TP53 and RELA\n", + "looking for paths in the network with length: 9 for node TP53 and RELA\n", + "looking for paths in the network with length: 10 for node TP53 and RELA\n", + "i_search = 4\n", + "Looking for paths with length: 0 for node TP53 and RELA\n", + "i_search = 4\n", + "Looking for paths with length: 1 for node TP53 and RELA\n", + "i_search = 4\n", + "Looking for paths with length: 2 for node TP53 and RELA\n", + "i_search = 4\n", + "Looking for paths with length: 3 for node TP53 and RELA\n", + "i_search = 4\n", + "Looking for paths with length: 4 for node TP53 and RELA\n", + "looking for paths in the network with length: 0 for node TP53 and MARCKS\n", + "looking for paths in the network with length: 1 for node TP53 and MARCKS\n", + "looking for paths in the network with length: 2 for node TP53 and MARCKS\n", + "looking for paths in the network with length: 3 for node TP53 and MARCKS\n", + "looking for paths in the network with length: 4 for node TP53 and MARCKS\n", + "looking for paths in the network with length: 5 for node TP53 and MARCKS\n", + "looking for paths in the network with length: 6 for node TP53 and MARCKS\n", + "looking for paths in the network with length: 7 for node TP53 and MARCKS\n", + "looking for paths in the network with length: 8 for node TP53 and MARCKS\n", + "looking for paths in the network with length: 9 for node TP53 and MARCKS\n", + "looking for paths in the network with length: 10 for node TP53 and MARCKS\n", + "i_search = 4\n", + "Looking for paths with length: 0 for node TP53 and MARCKS\n", + "i_search = 4\n", + "Looking for paths with length: 1 for node TP53 and MARCKS\n", + "i_search = 4\n", + "Looking for paths with length: 2 for node TP53 and MARCKS\n", + "i_search = 4\n", + "Looking for paths with length: 3 for node TP53 and MARCKS\n", + "i_search = 4\n", + "Looking for paths with length: 4 for node TP53 and MARCKS\n", + "looking for paths in the network with length: 0 for node AKT1S1 and GSK3B\n", + "looking for paths in the network with length: 1 for node AKT1S1 and GSK3B\n", + "looking for paths in the network with length: 2 for node AKT1S1 and GSK3B\n", + "looking for paths in the network with length: 3 for node AKT1S1 and GSK3B\n", + "looking for paths in the network with length: 4 for node AKT1S1 and GSK3B\n", + "looking for paths in the network with length: 5 for node AKT1S1 and GSK3B\n", + "looking for paths in the network with length: 6 for node AKT1S1 and GSK3B\n", + "looking for paths in the network with length: 7 for node AKT1S1 and GSK3B\n", + "looking for paths in the network with length: 8 for node AKT1S1 and GSK3B\n", + "looking for paths in the network with length: 9 for node AKT1S1 and GSK3B\n", + "looking for paths in the network with length: 10 for node AKT1S1 and GSK3B\n", + "i_search = 4\n", + "Looking for paths with length: 0 for node AKT1S1 and GSK3B\n", + "i_search = 4\n", + "Looking for paths with length: 1 for node AKT1S1 and GSK3B\n", + "i_search = 4\n", + "Looking for paths with length: 2 for node AKT1S1 and GSK3B\n", + "i_search = 4\n", + "Looking for paths with length: 3 for node AKT1S1 and GSK3B\n", + "i_search = 4\n", + "Looking for paths with length: 4 for node AKT1S1 and GSK3B\n", + "looking for paths in the network with length: 0 for node AKT1S1 and AKT1\n", + "looking for paths in the network with length: 1 for node AKT1S1 and AKT1\n", + "looking for paths in the network with length: 2 for node AKT1S1 and AKT1\n", + "looking for paths in the network with length: 3 for node AKT1S1 and AKT1\n", + "looking for paths in the network with length: 4 for node AKT1S1 and AKT1\n", + "looking for paths in the network with length: 5 for node AKT1S1 and AKT1\n", + "looking for paths in the network with length: 6 for node AKT1S1 and AKT1\n", + "looking for paths in the network with length: 7 for node AKT1S1 and AKT1\n", + "looking for paths in the network with length: 8 for node AKT1S1 and AKT1\n", + "looking for paths in the network with length: 9 for node AKT1S1 and AKT1\n", + "looking for paths in the network with length: 10 for node AKT1S1 and AKT1\n", + "i_search = 4\n", + "Looking for paths with length: 0 for node AKT1S1 and AKT1\n", + "i_search = 4\n", + "Looking for paths with length: 1 for node AKT1S1 and AKT1\n", + "i_search = 4\n", + "Looking for paths with length: 2 for node AKT1S1 and AKT1\n", + "i_search = 4\n", + "Looking for paths with length: 3 for node AKT1S1 and AKT1\n", + "i_search = 4\n", + "Looking for paths with length: 4 for node AKT1S1 and AKT1\n", + "looking for paths in the network with length: 0 for node AKT1S1 and HSPB1\n", + "looking for paths in the network with length: 1 for node AKT1S1 and HSPB1\n", + "looking for paths in the network with length: 2 for node AKT1S1 and HSPB1\n", + "looking for paths in the network with length: 3 for node AKT1S1 and HSPB1\n", + "looking for paths in the network with length: 4 for node AKT1S1 and HSPB1\n", + "looking for paths in the network with length: 5 for node AKT1S1 and HSPB1\n", + "looking for paths in the network with length: 6 for node AKT1S1 and HSPB1\n", + "looking for paths in the network with length: 7 for node AKT1S1 and HSPB1\n", + "looking for paths in the network with length: 8 for node AKT1S1 and HSPB1\n", + "looking for paths in the network with length: 9 for node AKT1S1 and HSPB1\n", + "looking for paths in the network with length: 10 for node AKT1S1 and HSPB1\n", + "i_search = 4\n", + "Looking for paths with length: 0 for node AKT1S1 and HSPB1\n", + "i_search = 4\n", + "Looking for paths with length: 1 for node AKT1S1 and HSPB1\n", + "i_search = 4\n", + "Looking for paths with length: 2 for node AKT1S1 and HSPB1\n", + "i_search = 4\n", + "Looking for paths with length: 3 for node AKT1S1 and HSPB1\n", + "i_search = 4\n", + "Looking for paths with length: 4 for node AKT1S1 and HSPB1\n", + "looking for paths in the network with length: 0 for node AKT1S1 and MAPK14\n", + "looking for paths in the network with length: 1 for node AKT1S1 and MAPK14\n", + "looking for paths in the network with length: 2 for node AKT1S1 and MAPK14\n", + "looking for paths in the network with length: 3 for node AKT1S1 and MAPK14\n", + "looking for paths in the network with length: 4 for node AKT1S1 and MAPK14\n", + "looking for paths in the network with length: 5 for node AKT1S1 and MAPK14\n", + "looking for paths in the network with length: 6 for node AKT1S1 and MAPK14\n", + "looking for paths in the network with length: 7 for node AKT1S1 and MAPK14\n", + "looking for paths in the network with length: 8 for node AKT1S1 and MAPK14\n", + "looking for paths in the network with length: 9 for node AKT1S1 and MAPK14\n", + "looking for paths in the network with length: 10 for node AKT1S1 and MAPK14\n", + "i_search = 4\n", + "Looking for paths with length: 0 for node AKT1S1 and MAPK14\n", + "i_search = 4\n", + "Looking for paths with length: 1 for node AKT1S1 and MAPK14\n", + "i_search = 4\n", + "Looking for paths with length: 2 for node AKT1S1 and MAPK14\n", + "i_search = 4\n", + "Looking for paths with length: 3 for node AKT1S1 and MAPK14\n", + "i_search = 4\n", + "Looking for paths with length: 4 for node AKT1S1 and MAPK14\n", + "looking for paths in the network with length: 0 for node AKT1S1 and MAP2K1\n", + "looking for paths in the network with length: 1 for node AKT1S1 and MAP2K1\n", + "looking for paths in the network with length: 2 for node AKT1S1 and MAP2K1\n", + "looking for paths in the network with length: 3 for node AKT1S1 and MAP2K1\n", + "looking for paths in the network with length: 4 for node AKT1S1 and MAP2K1\n", + "looking for paths in the network with length: 5 for node AKT1S1 and MAP2K1\n", + "looking for paths in the network with length: 6 for node AKT1S1 and MAP2K1\n", + "looking for paths in the network with length: 7 for node AKT1S1 and MAP2K1\n", + "looking for paths in the network with length: 8 for node AKT1S1 and MAP2K1\n", + "looking for paths in the network with length: 9 for node AKT1S1 and MAP2K1\n", + "looking for paths in the network with length: 10 for node AKT1S1 and MAP2K1\n", + "i_search = 4\n", + "Looking for paths with length: 0 for node AKT1S1 and MAP2K1\n", + "i_search = 4\n", + "Looking for paths with length: 1 for node AKT1S1 and MAP2K1\n", + "i_search = 4\n", + "Looking for paths with length: 2 for node AKT1S1 and MAP2K1\n", + "i_search = 4\n", + "Looking for paths with length: 3 for node AKT1S1 and MAP2K1\n", + "i_search = 4\n", + "Looking for paths with length: 4 for node AKT1S1 and MAP2K1\n", + "looking for paths in the network with length: 0 for node AKT1S1 and RPS6KA1\n", + "looking for paths in the network with length: 1 for node AKT1S1 and RPS6KA1\n", + "looking for paths in the network with length: 2 for node AKT1S1 and RPS6KA1\n", + "looking for paths in the network with length: 3 for node AKT1S1 and RPS6KA1\n", + "looking for paths in the network with length: 4 for node AKT1S1 and RPS6KA1\n", + "looking for paths in the network with length: 5 for node AKT1S1 and RPS6KA1\n", + "looking for paths in the network with length: 6 for node AKT1S1 and RPS6KA1\n", + "looking for paths in the network with length: 7 for node AKT1S1 and RPS6KA1\n", + "looking for paths in the network with length: 8 for node AKT1S1 and RPS6KA1\n", + "looking for paths in the network with length: 9 for node AKT1S1 and RPS6KA1\n", + "looking for paths in the network with length: 10 for node AKT1S1 and RPS6KA1\n", + "i_search = 4\n", + "Looking for paths with length: 0 for node AKT1S1 and RPS6KA1\n", + "i_search = 4\n", + "Looking for paths with length: 1 for node AKT1S1 and RPS6KA1\n", + "i_search = 4\n", + "Looking for paths with length: 2 for node AKT1S1 and RPS6KA1\n", + "i_search = 4\n", + "Looking for paths with length: 3 for node AKT1S1 and RPS6KA1\n", + "i_search = 4\n", + "Looking for paths with length: 4 for node AKT1S1 and RPS6KA1\n", + "looking for paths in the network with length: 0 for node AKT1S1 and CREB1\n", + "looking for paths in the network with length: 1 for node AKT1S1 and CREB1\n", + "looking for paths in the network with length: 2 for node AKT1S1 and CREB1\n", + "looking for paths in the network with length: 3 for node AKT1S1 and CREB1\n", + "looking for paths in the network with length: 4 for node AKT1S1 and CREB1\n", + "looking for paths in the network with length: 5 for node AKT1S1 and CREB1\n", + "looking for paths in the network with length: 6 for node AKT1S1 and CREB1\n", + "looking for paths in the network with length: 7 for node AKT1S1 and CREB1\n", + "looking for paths in the network with length: 8 for node AKT1S1 and CREB1\n", + "looking for paths in the network with length: 9 for node AKT1S1 and CREB1\n", + "looking for paths in the network with length: 10 for node AKT1S1 and CREB1\n", + "i_search = 4\n", + "Looking for paths with length: 0 for node AKT1S1 and CREB1\n", + "i_search = 4\n", + "Looking for paths with length: 1 for node AKT1S1 and CREB1\n", + "i_search = 4\n", + "Looking for paths with length: 2 for node AKT1S1 and CREB1\n", + "i_search = 4\n", + "Looking for paths with length: 3 for node AKT1S1 and CREB1\n", + "i_search = 4\n", + "Looking for paths with length: 4 for node AKT1S1 and CREB1\n", + "looking for paths in the network with length: 0 for node AKT1S1 and NFKBIA\n", + "looking for paths in the network with length: 1 for node AKT1S1 and NFKBIA\n", + "looking for paths in the network with length: 2 for node AKT1S1 and NFKBIA\n", + "looking for paths in the network with length: 3 for node AKT1S1 and NFKBIA\n", + "looking for paths in the network with length: 4 for node AKT1S1 and NFKBIA\n", + "looking for paths in the network with length: 5 for node AKT1S1 and NFKBIA\n", + "looking for paths in the network with length: 6 for node AKT1S1 and NFKBIA\n", + "looking for paths in the network with length: 7 for node AKT1S1 and NFKBIA\n", + "looking for paths in the network with length: 8 for node AKT1S1 and NFKBIA\n", + "looking for paths in the network with length: 9 for node AKT1S1 and NFKBIA\n", + "looking for paths in the network with length: 10 for node AKT1S1 and NFKBIA\n", + "i_search = 4\n", + "Looking for paths with length: 0 for node AKT1S1 and NFKBIA\n", + "i_search = 4\n", + "Looking for paths with length: 1 for node AKT1S1 and NFKBIA\n", + "i_search = 4\n", + "Looking for paths with length: 2 for node AKT1S1 and NFKBIA\n", + "i_search = 4\n", + "Looking for paths with length: 3 for node AKT1S1 and NFKBIA\n", + "i_search = 4\n", + "Looking for paths with length: 4 for node AKT1S1 and NFKBIA\n", + "looking for paths in the network with length: 0 for node AKT1S1 and MTOR\n", + "looking for paths in the network with length: 1 for node AKT1S1 and MTOR\n", + "looking for paths in the network with length: 2 for node AKT1S1 and MTOR\n", + "looking for paths in the network with length: 3 for node AKT1S1 and MTOR\n", + "looking for paths in the network with length: 4 for node AKT1S1 and MTOR\n", + "looking for paths in the network with length: 5 for node AKT1S1 and MTOR\n", + "looking for paths in the network with length: 6 for node AKT1S1 and MTOR\n", + "looking for paths in the network with length: 7 for node AKT1S1 and MTOR\n", + "looking for paths in the network with length: 8 for node AKT1S1 and MTOR\n", + "looking for paths in the network with length: 9 for node AKT1S1 and MTOR\n", + "looking for paths in the network with length: 10 for node AKT1S1 and MTOR\n", + "i_search = 4\n", + "Looking for paths with length: 0 for node AKT1S1 and MTOR\n", + "i_search = 4\n", + "Looking for paths with length: 1 for node AKT1S1 and MTOR\n", + "i_search = 4\n", + "Looking for paths with length: 2 for node AKT1S1 and MTOR\n", + "i_search = 4\n", + "Looking for paths with length: 3 for node AKT1S1 and MTOR\n", + "i_search = 4\n", + "Looking for paths with length: 4 for node AKT1S1 and MTOR\n", + "looking for paths in the network with length: 0 for node AKT1S1 and JUN\n", + "looking for paths in the network with length: 1 for node AKT1S1 and JUN\n", + "looking for paths in the network with length: 2 for node AKT1S1 and JUN\n", + "looking for paths in the network with length: 3 for node AKT1S1 and JUN\n", + "looking for paths in the network with length: 4 for node AKT1S1 and JUN\n", + "looking for paths in the network with length: 5 for node AKT1S1 and JUN\n", + "looking for paths in the network with length: 6 for node AKT1S1 and JUN\n", + "looking for paths in the network with length: 7 for node AKT1S1 and JUN\n", + "looking for paths in the network with length: 8 for node AKT1S1 and JUN\n", + "looking for paths in the network with length: 9 for node AKT1S1 and JUN\n", + "looking for paths in the network with length: 10 for node AKT1S1 and JUN\n", + "i_search = 4\n", + "Looking for paths with length: 0 for node AKT1S1 and JUN\n", + "i_search = 4\n", + "Looking for paths with length: 1 for node AKT1S1 and JUN\n", + "i_search = 4\n", + "Looking for paths with length: 2 for node AKT1S1 and JUN\n", + "i_search = 4\n", + "Looking for paths with length: 3 for node AKT1S1 and JUN\n", + "i_search = 4\n", + "Looking for paths with length: 4 for node AKT1S1 and JUN\n", + "looking for paths in the network with length: 0 for node AKT1S1 and EGFR\n", + "looking for paths in the network with length: 1 for node AKT1S1 and EGFR\n", + "looking for paths in the network with length: 2 for node AKT1S1 and EGFR\n", + "looking for paths in the network with length: 3 for node AKT1S1 and EGFR\n", + "looking for paths in the network with length: 4 for node AKT1S1 and EGFR\n", + "looking for paths in the network with length: 5 for node AKT1S1 and EGFR\n", + "looking for paths in the network with length: 6 for node AKT1S1 and EGFR\n", + "looking for paths in the network with length: 7 for node AKT1S1 and EGFR\n", + "looking for paths in the network with length: 8 for node AKT1S1 and EGFR\n", + "looking for paths in the network with length: 9 for node AKT1S1 and EGFR\n", + "looking for paths in the network with length: 10 for node AKT1S1 and EGFR\n", + "i_search = 4\n", + "Looking for paths with length: 0 for node AKT1S1 and EGFR\n", + "i_search = 4\n", + "Looking for paths with length: 1 for node AKT1S1 and EGFR\n", + "i_search = 4\n", + "Looking for paths with length: 2 for node AKT1S1 and EGFR\n", + "i_search = 4\n", + "Looking for paths with length: 3 for node AKT1S1 and EGFR\n", + "i_search = 4\n", + "Looking for paths with length: 4 for node AKT1S1 and EGFR\n", + "looking for paths in the network with length: 0 for node AKT1S1 and MAPK3\n", + "looking for paths in the network with length: 1 for node AKT1S1 and MAPK3\n", + "looking for paths in the network with length: 2 for node AKT1S1 and MAPK3\n", + "looking for paths in the network with length: 3 for node AKT1S1 and MAPK3\n", + "looking for paths in the network with length: 4 for node AKT1S1 and MAPK3\n", + "looking for paths in the network with length: 5 for node AKT1S1 and MAPK3\n", + "looking for paths in the network with length: 6 for node AKT1S1 and MAPK3\n", + "looking for paths in the network with length: 7 for node AKT1S1 and MAPK3\n", + "looking for paths in the network with length: 8 for node AKT1S1 and MAPK3\n", + "looking for paths in the network with length: 9 for node AKT1S1 and MAPK3\n", + "looking for paths in the network with length: 10 for node AKT1S1 and MAPK3\n", + "i_search = 4\n", + "Looking for paths with length: 0 for node AKT1S1 and MAPK3\n", + "i_search = 4\n", + "Looking for paths with length: 1 for node AKT1S1 and MAPK3\n", + "i_search = 4\n", + "Looking for paths with length: 2 for node AKT1S1 and MAPK3\n", + "i_search = 4\n", + "Looking for paths with length: 3 for node AKT1S1 and MAPK3\n", + "i_search = 4\n", + "Looking for paths with length: 4 for node AKT1S1 and MAPK3\n", + "looking for paths in the network with length: 0 for node AKT1S1 and PTPN11\n", + "looking for paths in the network with length: 1 for node AKT1S1 and PTPN11\n", + "looking for paths in the network with length: 2 for node AKT1S1 and PTPN11\n", + "looking for paths in the network with length: 3 for node AKT1S1 and PTPN11\n", + "looking for paths in the network with length: 4 for node AKT1S1 and PTPN11\n", + "looking for paths in the network with length: 5 for node AKT1S1 and PTPN11\n", + "looking for paths in the network with length: 6 for node AKT1S1 and PTPN11\n", + "looking for paths in the network with length: 7 for node AKT1S1 and PTPN11\n", + "looking for paths in the network with length: 8 for node AKT1S1 and PTPN11\n", + "looking for paths in the network with length: 9 for node AKT1S1 and PTPN11\n", + "looking for paths in the network with length: 10 for node AKT1S1 and PTPN11\n", + "i_search = 4\n", + "Looking for paths with length: 0 for node AKT1S1 and PTPN11\n", + "i_search = 4\n", + "Looking for paths with length: 1 for node AKT1S1 and PTPN11\n", + "i_search = 4\n", + "Looking for paths with length: 2 for node AKT1S1 and PTPN11\n", + "i_search = 4\n", + "Looking for paths with length: 3 for node AKT1S1 and PTPN11\n", + "i_search = 4\n", + "Looking for paths with length: 4 for node AKT1S1 and PTPN11\n", + "looking for paths in the network with length: 0 for node AKT1S1 and STAT3\n", + "looking for paths in the network with length: 1 for node AKT1S1 and STAT3\n", + "looking for paths in the network with length: 2 for node AKT1S1 and STAT3\n", + "looking for paths in the network with length: 3 for node AKT1S1 and STAT3\n", + "looking for paths in the network with length: 4 for node AKT1S1 and STAT3\n", + "looking for paths in the network with length: 5 for node AKT1S1 and STAT3\n", + "looking for paths in the network with length: 6 for node AKT1S1 and STAT3\n", + "looking for paths in the network with length: 7 for node AKT1S1 and STAT3\n", + "looking for paths in the network with length: 8 for node AKT1S1 and STAT3\n", + "looking for paths in the network with length: 9 for node AKT1S1 and STAT3\n", + "looking for paths in the network with length: 10 for node AKT1S1 and STAT3\n", + "i_search = 4\n", + "Looking for paths with length: 0 for node AKT1S1 and STAT3\n", + "i_search = 4\n", + "Looking for paths with length: 1 for node AKT1S1 and STAT3\n", + "i_search = 4\n", + "Looking for paths with length: 2 for node AKT1S1 and STAT3\n", + "i_search = 4\n", + "Looking for paths with length: 3 for node AKT1S1 and STAT3\n", + "i_search = 4\n", + "Looking for paths with length: 4 for node AKT1S1 and STAT3\n", + "looking for paths in the network with length: 0 for node AKT1S1 and CHEK2\n", + "looking for paths in the network with length: 1 for node AKT1S1 and CHEK2\n", + "looking for paths in the network with length: 2 for node AKT1S1 and CHEK2\n", + "looking for paths in the network with length: 3 for node AKT1S1 and CHEK2\n", + "looking for paths in the network with length: 4 for node AKT1S1 and CHEK2\n", + "looking for paths in the network with length: 5 for node AKT1S1 and CHEK2\n", + "looking for paths in the network with length: 6 for node AKT1S1 and CHEK2\n", + "looking for paths in the network with length: 7 for node AKT1S1 and CHEK2\n", + "looking for paths in the network with length: 8 for node AKT1S1 and CHEK2\n", + "looking for paths in the network with length: 9 for node AKT1S1 and CHEK2\n", + "looking for paths in the network with length: 10 for node AKT1S1 and CHEK2\n", + "i_search = 4\n", + "Looking for paths with length: 0 for node AKT1S1 and CHEK2\n", + "i_search = 4\n", + "Looking for paths with length: 1 for node AKT1S1 and CHEK2\n", + "i_search = 4\n", + "Looking for paths with length: 2 for node AKT1S1 and CHEK2\n", + "i_search = 4\n", + "Looking for paths with length: 3 for node AKT1S1 and CHEK2\n", + "i_search = 4\n", + "Looking for paths with length: 4 for node AKT1S1 and CHEK2\n", + "looking for paths in the network with length: 0 for node AKT1S1 and RELA\n", + "looking for paths in the network with length: 1 for node AKT1S1 and RELA\n", + "looking for paths in the network with length: 2 for node AKT1S1 and RELA\n", + "looking for paths in the network with length: 3 for node AKT1S1 and RELA\n", + "looking for paths in the network with length: 4 for node AKT1S1 and RELA\n", + "looking for paths in the network with length: 5 for node AKT1S1 and RELA\n", + "looking for paths in the network with length: 6 for node AKT1S1 and RELA\n", + "looking for paths in the network with length: 7 for node AKT1S1 and RELA\n", + "looking for paths in the network with length: 8 for node AKT1S1 and RELA\n", + "looking for paths in the network with length: 9 for node AKT1S1 and RELA\n", + "looking for paths in the network with length: 10 for node AKT1S1 and RELA\n", + "i_search = 4\n", + "Looking for paths with length: 0 for node AKT1S1 and RELA\n", + "i_search = 4\n", + "Looking for paths with length: 1 for node AKT1S1 and RELA\n", + "i_search = 4\n", + "Looking for paths with length: 2 for node AKT1S1 and RELA\n", + "i_search = 4\n", + "Looking for paths with length: 3 for node AKT1S1 and RELA\n", + "i_search = 4\n", + "Looking for paths with length: 4 for node AKT1S1 and RELA\n", + "looking for paths in the network with length: 0 for node AKT1S1 and MARCKS\n", + "looking for paths in the network with length: 1 for node AKT1S1 and MARCKS\n", + "looking for paths in the network with length: 2 for node AKT1S1 and MARCKS\n", + "looking for paths in the network with length: 3 for node AKT1S1 and MARCKS\n", + "looking for paths in the network with length: 4 for node AKT1S1 and MARCKS\n", + "looking for paths in the network with length: 5 for node AKT1S1 and MARCKS\n", + "looking for paths in the network with length: 6 for node AKT1S1 and MARCKS\n", + "looking for paths in the network with length: 7 for node AKT1S1 and MARCKS\n", + "looking for paths in the network with length: 8 for node AKT1S1 and MARCKS\n", + "looking for paths in the network with length: 9 for node AKT1S1 and MARCKS\n", + "looking for paths in the network with length: 10 for node AKT1S1 and MARCKS\n", + "i_search = 4\n", + "Looking for paths with length: 0 for node AKT1S1 and MARCKS\n", + "i_search = 4\n", + "Looking for paths with length: 1 for node AKT1S1 and MARCKS\n", + "i_search = 4\n", + "Looking for paths with length: 2 for node AKT1S1 and MARCKS\n", + "i_search = 4\n", + "Looking for paths with length: 3 for node AKT1S1 and MARCKS\n", + "i_search = 4\n", + "Looking for paths with length: 4 for node AKT1S1 and MARCKS\n", + "looking for paths in the network with length: 0 for node GSK3B and AKT1\n", + "looking for paths in the network with length: 1 for node GSK3B and AKT1\n", + "looking for paths in the network with length: 2 for node GSK3B and AKT1\n", + "looking for paths in the network with length: 3 for node GSK3B and AKT1\n", + "looking for paths in the network with length: 4 for node GSK3B and AKT1\n", + "looking for paths in the network with length: 5 for node GSK3B and AKT1\n", + "looking for paths in the network with length: 6 for node GSK3B and AKT1\n", + "looking for paths in the network with length: 7 for node GSK3B and AKT1\n", + "looking for paths in the network with length: 8 for node GSK3B and AKT1\n", + "looking for paths in the network with length: 9 for node GSK3B and AKT1\n", + "looking for paths in the network with length: 10 for node GSK3B and AKT1\n", + "i_search = 4\n", + "Looking for paths with length: 0 for node GSK3B and AKT1\n", + "i_search = 4\n", + "Looking for paths with length: 1 for node GSK3B and AKT1\n", + "i_search = 4\n", + "Looking for paths with length: 2 for node GSK3B and AKT1\n", + "i_search = 4\n", + "Looking for paths with length: 3 for node GSK3B and AKT1\n", + "i_search = 4\n", + "Looking for paths with length: 4 for node GSK3B and AKT1\n", + "looking for paths in the network with length: 0 for node GSK3B and HSPB1\n", + "looking for paths in the network with length: 1 for node GSK3B and HSPB1\n", + "looking for paths in the network with length: 2 for node GSK3B and HSPB1\n", + "looking for paths in the network with length: 3 for node GSK3B and HSPB1\n", + "looking for paths in the network with length: 4 for node GSK3B and HSPB1\n", + "looking for paths in the network with length: 5 for node GSK3B and HSPB1\n", + "looking for paths in the network with length: 6 for node GSK3B and HSPB1\n", + "looking for paths in the network with length: 7 for node GSK3B and HSPB1\n", + "looking for paths in the network with length: 8 for node GSK3B and HSPB1\n", + "looking for paths in the network with length: 9 for node GSK3B and HSPB1\n", + "looking for paths in the network with length: 10 for node GSK3B and HSPB1\n", + "i_search = 4\n", + "Looking for paths with length: 0 for node GSK3B and HSPB1\n", + "i_search = 4\n", + "Looking for paths with length: 1 for node GSK3B and HSPB1\n", + "i_search = 4\n", + "Looking for paths with length: 2 for node GSK3B and HSPB1\n", + "i_search = 4\n", + "Looking for paths with length: 3 for node GSK3B and HSPB1\n", + "i_search = 4\n", + "Looking for paths with length: 4 for node GSK3B and HSPB1\n", + "looking for paths in the network with length: 0 for node GSK3B and MAPK14\n", + "looking for paths in the network with length: 1 for node GSK3B and MAPK14\n", + "looking for paths in the network with length: 2 for node GSK3B and MAPK14\n", + "looking for paths in the network with length: 3 for node GSK3B and MAPK14\n", + "looking for paths in the network with length: 4 for node GSK3B and MAPK14\n", + "looking for paths in the network with length: 5 for node GSK3B and MAPK14\n", + "looking for paths in the network with length: 6 for node GSK3B and MAPK14\n", + "looking for paths in the network with length: 7 for node GSK3B and MAPK14\n", + "looking for paths in the network with length: 8 for node GSK3B and MAPK14\n", + "looking for paths in the network with length: 9 for node GSK3B and MAPK14\n", + "looking for paths in the network with length: 10 for node GSK3B and MAPK14\n", + "i_search = 4\n", + "Looking for paths with length: 0 for node GSK3B and MAPK14\n", + "i_search = 4\n", + "Looking for paths with length: 1 for node GSK3B and MAPK14\n", + "i_search = 4\n", + "Looking for paths with length: 2 for node GSK3B and MAPK14\n", + "i_search = 4\n", + "Looking for paths with length: 3 for node GSK3B and MAPK14\n", + "i_search = 4\n", + "Looking for paths with length: 4 for node GSK3B and MAPK14\n", + "looking for paths in the network with length: 0 for node GSK3B and MAP2K1\n", + "looking for paths in the network with length: 1 for node GSK3B and MAP2K1\n", + "looking for paths in the network with length: 2 for node GSK3B and MAP2K1\n", + "looking for paths in the network with length: 3 for node GSK3B and MAP2K1\n", + "looking for paths in the network with length: 4 for node GSK3B and MAP2K1\n", + "looking for paths in the network with length: 5 for node GSK3B and MAP2K1\n", + "looking for paths in the network with length: 6 for node GSK3B and MAP2K1\n", + "looking for paths in the network with length: 7 for node GSK3B and MAP2K1\n", + "looking for paths in the network with length: 8 for node GSK3B and MAP2K1\n", + "looking for paths in the network with length: 9 for node GSK3B and MAP2K1\n", + "looking for paths in the network with length: 10 for node GSK3B and MAP2K1\n", + "i_search = 4\n", + "Looking for paths with length: 0 for node GSK3B and MAP2K1\n", + "i_search = 4\n", + "Looking for paths with length: 1 for node GSK3B and MAP2K1\n", + "i_search = 4\n", + "Looking for paths with length: 2 for node GSK3B and MAP2K1\n", + "i_search = 4\n", + "Looking for paths with length: 3 for node GSK3B and MAP2K1\n", + "i_search = 4\n", + "Looking for paths with length: 4 for node GSK3B and MAP2K1\n", + "looking for paths in the network with length: 0 for node GSK3B and RPS6KA1\n", + "looking for paths in the network with length: 1 for node GSK3B and RPS6KA1\n", + "looking for paths in the network with length: 2 for node GSK3B and RPS6KA1\n", + "looking for paths in the network with length: 3 for node GSK3B and RPS6KA1\n", + "looking for paths in the network with length: 4 for node GSK3B and RPS6KA1\n", + "looking for paths in the network with length: 5 for node GSK3B and RPS6KA1\n", + "looking for paths in the network with length: 6 for node GSK3B and RPS6KA1\n", + "looking for paths in the network with length: 7 for node GSK3B and RPS6KA1\n", + "looking for paths in the network with length: 8 for node GSK3B and RPS6KA1\n", + "looking for paths in the network with length: 9 for node GSK3B and RPS6KA1\n", + "looking for paths in the network with length: 10 for node GSK3B and RPS6KA1\n", + "i_search = 4\n", + "Looking for paths with length: 0 for node GSK3B and RPS6KA1\n", + "i_search = 4\n", + "Looking for paths with length: 1 for node GSK3B and RPS6KA1\n", + "i_search = 4\n", + "Looking for paths with length: 2 for node GSK3B and RPS6KA1\n", + "i_search = 4\n", + "Looking for paths with length: 3 for node GSK3B and RPS6KA1\n", + "i_search = 4\n", + "Looking for paths with length: 4 for node GSK3B and RPS6KA1\n", + "looking for paths in the network with length: 0 for node GSK3B and CREB1\n", + "looking for paths in the network with length: 1 for node GSK3B and CREB1\n", + "looking for paths in the network with length: 2 for node GSK3B and CREB1\n", + "looking for paths in the network with length: 3 for node GSK3B and CREB1\n", + "looking for paths in the network with length: 4 for node GSK3B and CREB1\n", + "looking for paths in the network with length: 5 for node GSK3B and CREB1\n", + "looking for paths in the network with length: 6 for node GSK3B and CREB1\n", + "looking for paths in the network with length: 7 for node GSK3B and CREB1\n", + "looking for paths in the network with length: 8 for node GSK3B and CREB1\n", + "looking for paths in the network with length: 9 for node GSK3B and CREB1\n", + "looking for paths in the network with length: 10 for node GSK3B and CREB1\n", + "i_search = 4\n", + "Looking for paths with length: 0 for node GSK3B and CREB1\n", + "i_search = 4\n", + "Looking for paths with length: 1 for node GSK3B and CREB1\n", + "i_search = 4\n", + "Looking for paths with length: 2 for node GSK3B and CREB1\n", + "i_search = 4\n", + "Looking for paths with length: 3 for node GSK3B and CREB1\n", + "i_search = 4\n", + "Looking for paths with length: 4 for node GSK3B and CREB1\n", + "looking for paths in the network with length: 0 for node GSK3B and NFKBIA\n", + "looking for paths in the network with length: 1 for node GSK3B and NFKBIA\n", + "looking for paths in the network with length: 2 for node GSK3B and NFKBIA\n", + "looking for paths in the network with length: 3 for node GSK3B and NFKBIA\n", + "looking for paths in the network with length: 4 for node GSK3B and NFKBIA\n", + "looking for paths in the network with length: 5 for node GSK3B and NFKBIA\n", + "looking for paths in the network with length: 6 for node GSK3B and NFKBIA\n", + "looking for paths in the network with length: 7 for node GSK3B and NFKBIA\n", + "looking for paths in the network with length: 8 for node GSK3B and NFKBIA\n", + "looking for paths in the network with length: 9 for node GSK3B and NFKBIA\n", + "looking for paths in the network with length: 10 for node GSK3B and NFKBIA\n", + "i_search = 4\n", + "Looking for paths with length: 0 for node GSK3B and NFKBIA\n", + "i_search = 4\n", + "Looking for paths with length: 1 for node GSK3B and NFKBIA\n", + "i_search = 4\n", + "Looking for paths with length: 2 for node GSK3B and NFKBIA\n", + "i_search = 4\n", + "Looking for paths with length: 3 for node GSK3B and NFKBIA\n", + "i_search = 4\n", + "Looking for paths with length: 4 for node GSK3B and NFKBIA\n", + "looking for paths in the network with length: 0 for node GSK3B and MTOR\n", + "looking for paths in the network with length: 1 for node GSK3B and MTOR\n", + "looking for paths in the network with length: 2 for node GSK3B and MTOR\n", + "looking for paths in the network with length: 3 for node GSK3B and MTOR\n", + "looking for paths in the network with length: 4 for node GSK3B and MTOR\n", + "looking for paths in the network with length: 5 for node GSK3B and MTOR\n", + "looking for paths in the network with length: 6 for node GSK3B and MTOR\n", + "looking for paths in the network with length: 7 for node GSK3B and MTOR\n", + "looking for paths in the network with length: 8 for node GSK3B and MTOR\n", + "looking for paths in the network with length: 9 for node GSK3B and MTOR\n", + "looking for paths in the network with length: 10 for node GSK3B and MTOR\n", + "i_search = 4\n", + "Looking for paths with length: 0 for node GSK3B and MTOR\n", + "i_search = 4\n", + "Looking for paths with length: 1 for node GSK3B and MTOR\n", + "i_search = 4\n", + "Looking for paths with length: 2 for node GSK3B and MTOR\n", + "i_search = 4\n", + "Looking for paths with length: 3 for node GSK3B and MTOR\n", + "i_search = 4\n", + "Looking for paths with length: 4 for node GSK3B and MTOR\n", + "looking for paths in the network with length: 0 for node GSK3B and JUN\n", + "looking for paths in the network with length: 1 for node GSK3B and JUN\n", + "looking for paths in the network with length: 2 for node GSK3B and JUN\n", + "looking for paths in the network with length: 3 for node GSK3B and JUN\n", + "looking for paths in the network with length: 4 for node GSK3B and JUN\n", + "looking for paths in the network with length: 5 for node GSK3B and JUN\n", + "looking for paths in the network with length: 6 for node GSK3B and JUN\n", + "looking for paths in the network with length: 7 for node GSK3B and JUN\n", + "looking for paths in the network with length: 8 for node GSK3B and JUN\n", + "looking for paths in the network with length: 9 for node GSK3B and JUN\n", + "looking for paths in the network with length: 10 for node GSK3B and JUN\n", + "i_search = 4\n", + "Looking for paths with length: 0 for node GSK3B and JUN\n", + "i_search = 4\n", + "Looking for paths with length: 1 for node GSK3B and JUN\n", + "i_search = 4\n", + "Looking for paths with length: 2 for node GSK3B and JUN\n", + "i_search = 4\n", + "Looking for paths with length: 3 for node GSK3B and JUN\n", + "i_search = 4\n", + "Looking for paths with length: 4 for node GSK3B and JUN\n", + "looking for paths in the network with length: 0 for node GSK3B and EGFR\n", + "looking for paths in the network with length: 1 for node GSK3B and EGFR\n", + "looking for paths in the network with length: 2 for node GSK3B and EGFR\n", + "looking for paths in the network with length: 3 for node GSK3B and EGFR\n", + "looking for paths in the network with length: 4 for node GSK3B and EGFR\n", + "looking for paths in the network with length: 5 for node GSK3B and EGFR\n", + "looking for paths in the network with length: 6 for node GSK3B and EGFR\n", + "looking for paths in the network with length: 7 for node GSK3B and EGFR\n", + "looking for paths in the network with length: 8 for node GSK3B and EGFR\n", + "looking for paths in the network with length: 9 for node GSK3B and EGFR\n", + "looking for paths in the network with length: 10 for node GSK3B and EGFR\n", + "i_search = 4\n", + "Looking for paths with length: 0 for node GSK3B and EGFR\n", + "i_search = 4\n", + "Looking for paths with length: 1 for node GSK3B and EGFR\n", + "i_search = 4\n", + "Looking for paths with length: 2 for node GSK3B and EGFR\n", + "i_search = 4\n", + "Looking for paths with length: 3 for node GSK3B and EGFR\n", + "i_search = 4\n", + "Looking for paths with length: 4 for node GSK3B and EGFR\n", + "looking for paths in the network with length: 0 for node GSK3B and MAPK3\n", + "looking for paths in the network with length: 1 for node GSK3B and MAPK3\n", + "looking for paths in the network with length: 2 for node GSK3B and MAPK3\n", + "looking for paths in the network with length: 3 for node GSK3B and MAPK3\n", + "looking for paths in the network with length: 4 for node GSK3B and MAPK3\n", + "looking for paths in the network with length: 5 for node GSK3B and MAPK3\n", + "looking for paths in the network with length: 6 for node GSK3B and MAPK3\n", + "looking for paths in the network with length: 7 for node GSK3B and MAPK3\n", + "looking for paths in the network with length: 8 for node GSK3B and MAPK3\n", + "looking for paths in the network with length: 9 for node GSK3B and MAPK3\n", + "looking for paths in the network with length: 10 for node GSK3B and MAPK3\n", + "i_search = 4\n", + "Looking for paths with length: 0 for node GSK3B and MAPK3\n", + "i_search = 4\n", + "Looking for paths with length: 1 for node GSK3B and MAPK3\n", + "i_search = 4\n", + "Looking for paths with length: 2 for node GSK3B and MAPK3\n", + "i_search = 4\n", + "Looking for paths with length: 3 for node GSK3B and MAPK3\n", + "i_search = 4\n", + "Looking for paths with length: 4 for node GSK3B and MAPK3\n", + "looking for paths in the network with length: 0 for node GSK3B and PTPN11\n", + "looking for paths in the network with length: 1 for node GSK3B and PTPN11\n", + "looking for paths in the network with length: 2 for node GSK3B and PTPN11\n", + "looking for paths in the network with length: 3 for node GSK3B and PTPN11\n", + "looking for paths in the network with length: 4 for node GSK3B and PTPN11\n", + "looking for paths in the network with length: 5 for node GSK3B and PTPN11\n", + "looking for paths in the network with length: 6 for node GSK3B and PTPN11\n", + "looking for paths in the network with length: 7 for node GSK3B and PTPN11\n", + "looking for paths in the network with length: 8 for node GSK3B and PTPN11\n", + "looking for paths in the network with length: 9 for node GSK3B and PTPN11\n", + "looking for paths in the network with length: 10 for node GSK3B and PTPN11\n", + "i_search = 4\n", + "Looking for paths with length: 0 for node GSK3B and PTPN11\n", + "i_search = 4\n", + "Looking for paths with length: 1 for node GSK3B and PTPN11\n", + "i_search = 4\n", + "Looking for paths with length: 2 for node GSK3B and PTPN11\n", + "i_search = 4\n", + "Looking for paths with length: 3 for node GSK3B and PTPN11\n", + "i_search = 4\n", + "Looking for paths with length: 4 for node GSK3B and PTPN11\n", + "looking for paths in the network with length: 0 for node GSK3B and STAT3\n", + "looking for paths in the network with length: 1 for node GSK3B and STAT3\n", + "looking for paths in the network with length: 2 for node GSK3B and STAT3\n", + "looking for paths in the network with length: 3 for node GSK3B and STAT3\n", + "looking for paths in the network with length: 4 for node GSK3B and STAT3\n", + "looking for paths in the network with length: 5 for node GSK3B and STAT3\n", + "looking for paths in the network with length: 6 for node GSK3B and STAT3\n", + "looking for paths in the network with length: 7 for node GSK3B and STAT3\n", + "looking for paths in the network with length: 8 for node GSK3B and STAT3\n", + "looking for paths in the network with length: 9 for node GSK3B and STAT3\n", + "looking for paths in the network with length: 10 for node GSK3B and STAT3\n", + "i_search = 4\n", + "Looking for paths with length: 0 for node GSK3B and STAT3\n", + "i_search = 4\n", + "Looking for paths with length: 1 for node GSK3B and STAT3\n", + "i_search = 4\n", + "Looking for paths with length: 2 for node GSK3B and STAT3\n", + "i_search = 4\n", + "Looking for paths with length: 3 for node GSK3B and STAT3\n", + "i_search = 4\n", + "Looking for paths with length: 4 for node GSK3B and STAT3\n", + "looking for paths in the network with length: 0 for node GSK3B and CHEK2\n", + "looking for paths in the network with length: 1 for node GSK3B and CHEK2\n", + "looking for paths in the network with length: 2 for node GSK3B and CHEK2\n", + "looking for paths in the network with length: 3 for node GSK3B and CHEK2\n", + "looking for paths in the network with length: 4 for node GSK3B and CHEK2\n", + "looking for paths in the network with length: 5 for node GSK3B and CHEK2\n", + "looking for paths in the network with length: 6 for node GSK3B and CHEK2\n", + "looking for paths in the network with length: 7 for node GSK3B and CHEK2\n", + "looking for paths in the network with length: 8 for node GSK3B and CHEK2\n", + "looking for paths in the network with length: 9 for node GSK3B and CHEK2\n", + "looking for paths in the network with length: 10 for node GSK3B and CHEK2\n", + "i_search = 4\n", + "Looking for paths with length: 0 for node GSK3B and CHEK2\n", + "i_search = 4\n", + "Looking for paths with length: 1 for node GSK3B and CHEK2\n", + "i_search = 4\n", + "Looking for paths with length: 2 for node GSK3B and CHEK2\n", + "i_search = 4\n", + "Looking for paths with length: 3 for node GSK3B and CHEK2\n", + "i_search = 4\n", + "Looking for paths with length: 4 for node GSK3B and CHEK2\n", + "looking for paths in the network with length: 0 for node GSK3B and RELA\n", + "looking for paths in the network with length: 1 for node GSK3B and RELA\n", + "looking for paths in the network with length: 2 for node GSK3B and RELA\n", + "looking for paths in the network with length: 3 for node GSK3B and RELA\n", + "looking for paths in the network with length: 4 for node GSK3B and RELA\n", + "looking for paths in the network with length: 5 for node GSK3B and RELA\n", + "looking for paths in the network with length: 6 for node GSK3B and RELA\n", + "looking for paths in the network with length: 7 for node GSK3B and RELA\n", + "looking for paths in the network with length: 8 for node GSK3B and RELA\n", + "looking for paths in the network with length: 9 for node GSK3B and RELA\n", + "looking for paths in the network with length: 10 for node GSK3B and RELA\n", + "i_search = 4\n", + "Looking for paths with length: 0 for node GSK3B and RELA\n", + "i_search = 4\n", + "Looking for paths with length: 1 for node GSK3B and RELA\n", + "i_search = 4\n", + "Looking for paths with length: 2 for node GSK3B and RELA\n", + "i_search = 4\n", + "Looking for paths with length: 3 for node GSK3B and RELA\n", + "i_search = 4\n", + "Looking for paths with length: 4 for node GSK3B and RELA\n", + "looking for paths in the network with length: 0 for node GSK3B and MARCKS\n", + "looking for paths in the network with length: 1 for node GSK3B and MARCKS\n", + "looking for paths in the network with length: 2 for node GSK3B and MARCKS\n", + "looking for paths in the network with length: 3 for node GSK3B and MARCKS\n", + "looking for paths in the network with length: 4 for node GSK3B and MARCKS\n", + "looking for paths in the network with length: 5 for node GSK3B and MARCKS\n", + "looking for paths in the network with length: 6 for node GSK3B and MARCKS\n", + "looking for paths in the network with length: 7 for node GSK3B and MARCKS\n", + "looking for paths in the network with length: 8 for node GSK3B and MARCKS\n", + "looking for paths in the network with length: 9 for node GSK3B and MARCKS\n", + "looking for paths in the network with length: 10 for node GSK3B and MARCKS\n", + "i_search = 4\n", + "Looking for paths with length: 0 for node GSK3B and MARCKS\n", + "i_search = 4\n", + "Looking for paths with length: 1 for node GSK3B and MARCKS\n", + "i_search = 4\n", + "Looking for paths with length: 2 for node GSK3B and MARCKS\n", + "i_search = 4\n", + "Looking for paths with length: 3 for node GSK3B and MARCKS\n", + "i_search = 4\n", + "Looking for paths with length: 4 for node GSK3B and MARCKS\n", + "looking for paths in the network with length: 0 for node AKT1 and HSPB1\n", + "looking for paths in the network with length: 1 for node AKT1 and HSPB1\n", + "looking for paths in the network with length: 2 for node AKT1 and HSPB1\n", + "looking for paths in the network with length: 3 for node AKT1 and HSPB1\n", + "looking for paths in the network with length: 4 for node AKT1 and HSPB1\n", + "looking for paths in the network with length: 5 for node AKT1 and HSPB1\n", + "looking for paths in the network with length: 6 for node AKT1 and HSPB1\n", + "looking for paths in the network with length: 7 for node AKT1 and HSPB1\n", + "looking for paths in the network with length: 8 for node AKT1 and HSPB1\n", + "looking for paths in the network with length: 9 for node AKT1 and HSPB1\n", + "looking for paths in the network with length: 10 for node AKT1 and HSPB1\n", + "i_search = 4\n", + "Looking for paths with length: 0 for node AKT1 and HSPB1\n", + "i_search = 4\n", + "Looking for paths with length: 1 for node AKT1 and HSPB1\n", + "i_search = 4\n", + "Looking for paths with length: 2 for node AKT1 and HSPB1\n", + "i_search = 4\n", + "Looking for paths with length: 3 for node AKT1 and HSPB1\n", + "i_search = 4\n", + "Looking for paths with length: 4 for node AKT1 and HSPB1\n", + "looking for paths in the network with length: 0 for node AKT1 and MAPK14\n", + "looking for paths in the network with length: 1 for node AKT1 and MAPK14\n", + "looking for paths in the network with length: 2 for node AKT1 and MAPK14\n", + "looking for paths in the network with length: 3 for node AKT1 and MAPK14\n", + "looking for paths in the network with length: 4 for node AKT1 and MAPK14\n", + "looking for paths in the network with length: 5 for node AKT1 and MAPK14\n", + "looking for paths in the network with length: 6 for node AKT1 and MAPK14\n", + "looking for paths in the network with length: 7 for node AKT1 and MAPK14\n", + "looking for paths in the network with length: 8 for node AKT1 and MAPK14\n", + "looking for paths in the network with length: 9 for node AKT1 and MAPK14\n", + "looking for paths in the network with length: 10 for node AKT1 and MAPK14\n", + "i_search = 4\n", + "Looking for paths with length: 0 for node AKT1 and MAPK14\n", + "i_search = 4\n", + "Looking for paths with length: 1 for node AKT1 and MAPK14\n", + "i_search = 4\n", + "Looking for paths with length: 2 for node AKT1 and MAPK14\n", + "i_search = 4\n", + "Looking for paths with length: 3 for node AKT1 and MAPK14\n", + "i_search = 4\n", + "Looking for paths with length: 4 for node AKT1 and MAPK14\n", + "looking for paths in the network with length: 0 for node AKT1 and MAP2K1\n", + "looking for paths in the network with length: 1 for node AKT1 and MAP2K1\n", + "looking for paths in the network with length: 2 for node AKT1 and MAP2K1\n", + "looking for paths in the network with length: 3 for node AKT1 and MAP2K1\n", + "looking for paths in the network with length: 4 for node AKT1 and MAP2K1\n", + "looking for paths in the network with length: 5 for node AKT1 and MAP2K1\n", + "looking for paths in the network with length: 6 for node AKT1 and MAP2K1\n", + "looking for paths in the network with length: 7 for node AKT1 and MAP2K1\n", + "looking for paths in the network with length: 8 for node AKT1 and MAP2K1\n", + "looking for paths in the network with length: 9 for node AKT1 and MAP2K1\n", + "looking for paths in the network with length: 10 for node AKT1 and MAP2K1\n", + "i_search = 4\n", + "Looking for paths with length: 0 for node AKT1 and MAP2K1\n", + "i_search = 4\n", + "Looking for paths with length: 1 for node AKT1 and MAP2K1\n", + "i_search = 4\n", + "Looking for paths with length: 2 for node AKT1 and MAP2K1\n", + "i_search = 4\n", + "Looking for paths with length: 3 for node AKT1 and MAP2K1\n", + "i_search = 4\n", + "Looking for paths with length: 4 for node AKT1 and MAP2K1\n", + "looking for paths in the network with length: 0 for node AKT1 and RPS6KA1\n", + "looking for paths in the network with length: 1 for node AKT1 and RPS6KA1\n", + "looking for paths in the network with length: 2 for node AKT1 and RPS6KA1\n", + "looking for paths in the network with length: 3 for node AKT1 and RPS6KA1\n", + "looking for paths in the network with length: 4 for node AKT1 and RPS6KA1\n", + "looking for paths in the network with length: 5 for node AKT1 and RPS6KA1\n", + "looking for paths in the network with length: 6 for node AKT1 and RPS6KA1\n", + "looking for paths in the network with length: 7 for node AKT1 and RPS6KA1\n", + "looking for paths in the network with length: 8 for node AKT1 and RPS6KA1\n", + "looking for paths in the network with length: 9 for node AKT1 and RPS6KA1\n", + "looking for paths in the network with length: 10 for node AKT1 and RPS6KA1\n", + "i_search = 4\n", + "Looking for paths with length: 0 for node AKT1 and RPS6KA1\n", + "i_search = 4\n", + "Looking for paths with length: 1 for node AKT1 and RPS6KA1\n", + "i_search = 4\n", + "Looking for paths with length: 2 for node AKT1 and RPS6KA1\n", + "i_search = 4\n", + "Looking for paths with length: 3 for node AKT1 and RPS6KA1\n", + "i_search = 4\n", + "Looking for paths with length: 4 for node AKT1 and RPS6KA1\n", + "looking for paths in the network with length: 0 for node AKT1 and CREB1\n", + "looking for paths in the network with length: 1 for node AKT1 and CREB1\n", + "looking for paths in the network with length: 2 for node AKT1 and CREB1\n", + "looking for paths in the network with length: 3 for node AKT1 and CREB1\n", + "looking for paths in the network with length: 4 for node AKT1 and CREB1\n", + "looking for paths in the network with length: 5 for node AKT1 and CREB1\n", + "looking for paths in the network with length: 6 for node AKT1 and CREB1\n", + "looking for paths in the network with length: 7 for node AKT1 and CREB1\n", + "looking for paths in the network with length: 8 for node AKT1 and CREB1\n", + "looking for paths in the network with length: 9 for node AKT1 and CREB1\n", + "looking for paths in the network with length: 10 for node AKT1 and CREB1\n", + "i_search = 4\n", + "Looking for paths with length: 0 for node AKT1 and CREB1\n", + "i_search = 4\n", + "Looking for paths with length: 1 for node AKT1 and CREB1\n", + "i_search = 4\n", + "Looking for paths with length: 2 for node AKT1 and CREB1\n", + "i_search = 4\n", + "Looking for paths with length: 3 for node AKT1 and CREB1\n", + "i_search = 4\n", + "Looking for paths with length: 4 for node AKT1 and CREB1\n", + "looking for paths in the network with length: 0 for node AKT1 and NFKBIA\n", + "looking for paths in the network with length: 1 for node AKT1 and NFKBIA\n", + "looking for paths in the network with length: 2 for node AKT1 and NFKBIA\n", + "looking for paths in the network with length: 3 for node AKT1 and NFKBIA\n", + "looking for paths in the network with length: 4 for node AKT1 and NFKBIA\n", + "looking for paths in the network with length: 5 for node AKT1 and NFKBIA\n", + "looking for paths in the network with length: 6 for node AKT1 and NFKBIA\n", + "looking for paths in the network with length: 7 for node AKT1 and NFKBIA\n", + "looking for paths in the network with length: 8 for node AKT1 and NFKBIA\n", + "looking for paths in the network with length: 9 for node AKT1 and NFKBIA\n", + "looking for paths in the network with length: 10 for node AKT1 and NFKBIA\n", + "i_search = 4\n", + "Looking for paths with length: 0 for node AKT1 and NFKBIA\n", + "i_search = 4\n", + "Looking for paths with length: 1 for node AKT1 and NFKBIA\n", + "i_search = 4\n", + "Looking for paths with length: 2 for node AKT1 and NFKBIA\n", + "i_search = 4\n", + "Looking for paths with length: 3 for node AKT1 and NFKBIA\n", + "i_search = 4\n", + "Looking for paths with length: 4 for node AKT1 and NFKBIA\n", + "looking for paths in the network with length: 0 for node AKT1 and MTOR\n", + "looking for paths in the network with length: 1 for node AKT1 and MTOR\n", + "looking for paths in the network with length: 2 for node AKT1 and MTOR\n", + "looking for paths in the network with length: 3 for node AKT1 and MTOR\n", + "looking for paths in the network with length: 4 for node AKT1 and MTOR\n", + "looking for paths in the network with length: 5 for node AKT1 and MTOR\n", + "looking for paths in the network with length: 6 for node AKT1 and MTOR\n", + "looking for paths in the network with length: 7 for node AKT1 and MTOR\n", + "looking for paths in the network with length: 8 for node AKT1 and MTOR\n", + "looking for paths in the network with length: 9 for node AKT1 and MTOR\n", + "looking for paths in the network with length: 10 for node AKT1 and MTOR\n", + "i_search = 4\n", + "Looking for paths with length: 0 for node AKT1 and MTOR\n", + "i_search = 4\n", + "Looking for paths with length: 1 for node AKT1 and MTOR\n", + "i_search = 4\n", + "Looking for paths with length: 2 for node AKT1 and MTOR\n", + "i_search = 4\n", + "Looking for paths with length: 3 for node AKT1 and MTOR\n", + "i_search = 4\n", + "Looking for paths with length: 4 for node AKT1 and MTOR\n", + "looking for paths in the network with length: 0 for node AKT1 and JUN\n", + "looking for paths in the network with length: 1 for node AKT1 and JUN\n", + "looking for paths in the network with length: 2 for node AKT1 and JUN\n", + "looking for paths in the network with length: 3 for node AKT1 and JUN\n", + "looking for paths in the network with length: 4 for node AKT1 and JUN\n", + "looking for paths in the network with length: 5 for node AKT1 and JUN\n", + "looking for paths in the network with length: 6 for node AKT1 and JUN\n", + "looking for paths in the network with length: 7 for node AKT1 and JUN\n", + "looking for paths in the network with length: 8 for node AKT1 and JUN\n", + "looking for paths in the network with length: 9 for node AKT1 and JUN\n", + "looking for paths in the network with length: 10 for node AKT1 and JUN\n", + "i_search = 4\n", + "Looking for paths with length: 0 for node AKT1 and JUN\n", + "i_search = 4\n", + "Looking for paths with length: 1 for node AKT1 and JUN\n", + "i_search = 4\n", + "Looking for paths with length: 2 for node AKT1 and JUN\n", + "i_search = 4\n", + "Looking for paths with length: 3 for node AKT1 and JUN\n", + "i_search = 4\n", + "Looking for paths with length: 4 for node AKT1 and JUN\n", + "looking for paths in the network with length: 0 for node AKT1 and EGFR\n", + "looking for paths in the network with length: 1 for node AKT1 and EGFR\n", + "looking for paths in the network with length: 2 for node AKT1 and EGFR\n", + "looking for paths in the network with length: 3 for node AKT1 and EGFR\n", + "looking for paths in the network with length: 4 for node AKT1 and EGFR\n", + "looking for paths in the network with length: 5 for node AKT1 and EGFR\n", + "looking for paths in the network with length: 6 for node AKT1 and EGFR\n", + "looking for paths in the network with length: 7 for node AKT1 and EGFR\n", + "looking for paths in the network with length: 8 for node AKT1 and EGFR\n", + "looking for paths in the network with length: 9 for node AKT1 and EGFR\n", + "looking for paths in the network with length: 10 for node AKT1 and EGFR\n", + "i_search = 4\n", + "Looking for paths with length: 0 for node AKT1 and EGFR\n", + "i_search = 4\n", + "Looking for paths with length: 1 for node AKT1 and EGFR\n", + "i_search = 4\n", + "Looking for paths with length: 2 for node AKT1 and EGFR\n", + "i_search = 4\n", + "Looking for paths with length: 3 for node AKT1 and EGFR\n", + "i_search = 4\n", + "Looking for paths with length: 4 for node AKT1 and EGFR\n", + "looking for paths in the network with length: 0 for node AKT1 and MAPK3\n", + "looking for paths in the network with length: 1 for node AKT1 and MAPK3\n", + "looking for paths in the network with length: 2 for node AKT1 and MAPK3\n", + "looking for paths in the network with length: 3 for node AKT1 and MAPK3\n", + "looking for paths in the network with length: 4 for node AKT1 and MAPK3\n", + "looking for paths in the network with length: 5 for node AKT1 and MAPK3\n", + "looking for paths in the network with length: 6 for node AKT1 and MAPK3\n", + "looking for paths in the network with length: 7 for node AKT1 and MAPK3\n", + "looking for paths in the network with length: 8 for node AKT1 and MAPK3\n", + "looking for paths in the network with length: 9 for node AKT1 and MAPK3\n", + "looking for paths in the network with length: 10 for node AKT1 and MAPK3\n", + "i_search = 4\n", + "Looking for paths with length: 0 for node AKT1 and MAPK3\n", + "i_search = 4\n", + "Looking for paths with length: 1 for node AKT1 and MAPK3\n", + "i_search = 4\n", + "Looking for paths with length: 2 for node AKT1 and MAPK3\n", + "i_search = 4\n", + "Looking for paths with length: 3 for node AKT1 and MAPK3\n", + "i_search = 4\n", + "Looking for paths with length: 4 for node AKT1 and MAPK3\n", + "looking for paths in the network with length: 0 for node AKT1 and PTPN11\n", + "looking for paths in the network with length: 1 for node AKT1 and PTPN11\n", + "looking for paths in the network with length: 2 for node AKT1 and PTPN11\n", + "looking for paths in the network with length: 3 for node AKT1 and PTPN11\n", + "looking for paths in the network with length: 4 for node AKT1 and PTPN11\n", + "looking for paths in the network with length: 5 for node AKT1 and PTPN11\n", + "looking for paths in the network with length: 6 for node AKT1 and PTPN11\n", + "looking for paths in the network with length: 7 for node AKT1 and PTPN11\n", + "looking for paths in the network with length: 8 for node AKT1 and PTPN11\n", + "looking for paths in the network with length: 9 for node AKT1 and PTPN11\n", + "looking for paths in the network with length: 10 for node AKT1 and PTPN11\n", + "i_search = 4\n", + "Looking for paths with length: 0 for node AKT1 and PTPN11\n", + "i_search = 4\n", + "Looking for paths with length: 1 for node AKT1 and PTPN11\n", + "i_search = 4\n", + "Looking for paths with length: 2 for node AKT1 and PTPN11\n", + "i_search = 4\n", + "Looking for paths with length: 3 for node AKT1 and PTPN11\n", + "i_search = 4\n", + "Looking for paths with length: 4 for node AKT1 and PTPN11\n", + "looking for paths in the network with length: 0 for node AKT1 and STAT3\n", + "looking for paths in the network with length: 1 for node AKT1 and STAT3\n", + "looking for paths in the network with length: 2 for node AKT1 and STAT3\n", + "looking for paths in the network with length: 3 for node AKT1 and STAT3\n", + "looking for paths in the network with length: 4 for node AKT1 and STAT3\n", + "looking for paths in the network with length: 5 for node AKT1 and STAT3\n", + "looking for paths in the network with length: 6 for node AKT1 and STAT3\n", + "looking for paths in the network with length: 7 for node AKT1 and STAT3\n", + "looking for paths in the network with length: 8 for node AKT1 and STAT3\n", + "looking for paths in the network with length: 9 for node AKT1 and STAT3\n", + "looking for paths in the network with length: 10 for node AKT1 and STAT3\n", + "i_search = 4\n", + "Looking for paths with length: 0 for node AKT1 and STAT3\n", + "i_search = 4\n", + "Looking for paths with length: 1 for node AKT1 and STAT3\n", + "i_search = 4\n", + "Looking for paths with length: 2 for node AKT1 and STAT3\n", + "i_search = 4\n", + "Looking for paths with length: 3 for node AKT1 and STAT3\n", + "i_search = 4\n", + "Looking for paths with length: 4 for node AKT1 and STAT3\n", + "looking for paths in the network with length: 0 for node AKT1 and CHEK2\n", + "looking for paths in the network with length: 1 for node AKT1 and CHEK2\n", + "looking for paths in the network with length: 2 for node AKT1 and CHEK2\n", + "looking for paths in the network with length: 3 for node AKT1 and CHEK2\n", + "looking for paths in the network with length: 4 for node AKT1 and CHEK2\n", + "looking for paths in the network with length: 5 for node AKT1 and CHEK2\n", + "looking for paths in the network with length: 6 for node AKT1 and CHEK2\n", + "looking for paths in the network with length: 7 for node AKT1 and CHEK2\n", + "looking for paths in the network with length: 8 for node AKT1 and CHEK2\n", + "looking for paths in the network with length: 9 for node AKT1 and CHEK2\n", + "looking for paths in the network with length: 10 for node AKT1 and CHEK2\n", + "i_search = 4\n", + "Looking for paths with length: 0 for node AKT1 and CHEK2\n", + "i_search = 4\n", + "Looking for paths with length: 1 for node AKT1 and CHEK2\n", + "i_search = 4\n", + "Looking for paths with length: 2 for node AKT1 and CHEK2\n", + "i_search = 4\n", + "Looking for paths with length: 3 for node AKT1 and CHEK2\n", + "i_search = 4\n", + "Looking for paths with length: 4 for node AKT1 and CHEK2\n", + "looking for paths in the network with length: 0 for node AKT1 and RELA\n", + "looking for paths in the network with length: 1 for node AKT1 and RELA\n", + "looking for paths in the network with length: 2 for node AKT1 and RELA\n", + "looking for paths in the network with length: 3 for node AKT1 and RELA\n", + "looking for paths in the network with length: 4 for node AKT1 and RELA\n", + "looking for paths in the network with length: 5 for node AKT1 and RELA\n", + "looking for paths in the network with length: 6 for node AKT1 and RELA\n", + "looking for paths in the network with length: 7 for node AKT1 and RELA\n", + "looking for paths in the network with length: 8 for node AKT1 and RELA\n", + "looking for paths in the network with length: 9 for node AKT1 and RELA\n", + "looking for paths in the network with length: 10 for node AKT1 and RELA\n", + "i_search = 4\n", + "Looking for paths with length: 0 for node AKT1 and RELA\n", + "i_search = 4\n", + "Looking for paths with length: 1 for node AKT1 and RELA\n", + "i_search = 4\n", + "Looking for paths with length: 2 for node AKT1 and RELA\n", + "i_search = 4\n", + "Looking for paths with length: 3 for node AKT1 and RELA\n", + "i_search = 4\n", + "Looking for paths with length: 4 for node AKT1 and RELA\n", + "looking for paths in the network with length: 0 for node AKT1 and MARCKS\n", + "looking for paths in the network with length: 1 for node AKT1 and MARCKS\n", + "looking for paths in the network with length: 2 for node AKT1 and MARCKS\n", + "looking for paths in the network with length: 3 for node AKT1 and MARCKS\n", + "looking for paths in the network with length: 4 for node AKT1 and MARCKS\n", + "looking for paths in the network with length: 5 for node AKT1 and MARCKS\n", + "looking for paths in the network with length: 6 for node AKT1 and MARCKS\n", + "looking for paths in the network with length: 7 for node AKT1 and MARCKS\n", + "looking for paths in the network with length: 8 for node AKT1 and MARCKS\n", + "looking for paths in the network with length: 9 for node AKT1 and MARCKS\n", + "looking for paths in the network with length: 10 for node AKT1 and MARCKS\n", + "i_search = 4\n", + "Looking for paths with length: 0 for node AKT1 and MARCKS\n", + "i_search = 4\n", + "Looking for paths with length: 1 for node AKT1 and MARCKS\n", + "i_search = 4\n", + "Looking for paths with length: 2 for node AKT1 and MARCKS\n", + "i_search = 4\n", + "Looking for paths with length: 3 for node AKT1 and MARCKS\n", + "i_search = 4\n", + "Looking for paths with length: 4 for node AKT1 and MARCKS\n", + "looking for paths in the network with length: 0 for node HSPB1 and MAPK14\n", + "looking for paths in the network with length: 1 for node HSPB1 and MAPK14\n", + "looking for paths in the network with length: 2 for node HSPB1 and MAPK14\n", + "looking for paths in the network with length: 3 for node HSPB1 and MAPK14\n", + "looking for paths in the network with length: 4 for node HSPB1 and MAPK14\n", + "looking for paths in the network with length: 5 for node HSPB1 and MAPK14\n", + "looking for paths in the network with length: 6 for node HSPB1 and MAPK14\n", + "looking for paths in the network with length: 7 for node HSPB1 and MAPK14\n", + "looking for paths in the network with length: 8 for node HSPB1 and MAPK14\n", + "looking for paths in the network with length: 9 for node HSPB1 and MAPK14\n", + "looking for paths in the network with length: 10 for node HSPB1 and MAPK14\n", + "i_search = 4\n", + "Looking for paths with length: 0 for node HSPB1 and MAPK14\n", + "i_search = 4\n", + "Looking for paths with length: 1 for node HSPB1 and MAPK14\n", + "i_search = 4\n", + "Looking for paths with length: 2 for node HSPB1 and MAPK14\n", + "i_search = 4\n", + "Looking for paths with length: 3 for node HSPB1 and MAPK14\n", + "i_search = 4\n", + "Looking for paths with length: 4 for node HSPB1 and MAPK14\n", + "looking for paths in the network with length: 0 for node HSPB1 and MAP2K1\n", + "looking for paths in the network with length: 1 for node HSPB1 and MAP2K1\n", + "looking for paths in the network with length: 2 for node HSPB1 and MAP2K1\n", + "looking for paths in the network with length: 3 for node HSPB1 and MAP2K1\n", + "looking for paths in the network with length: 4 for node HSPB1 and MAP2K1\n", + "looking for paths in the network with length: 5 for node HSPB1 and MAP2K1\n", + "looking for paths in the network with length: 6 for node HSPB1 and MAP2K1\n", + "looking for paths in the network with length: 7 for node HSPB1 and MAP2K1\n", + "looking for paths in the network with length: 8 for node HSPB1 and MAP2K1\n", + "looking for paths in the network with length: 9 for node HSPB1 and MAP2K1\n", + "looking for paths in the network with length: 10 for node HSPB1 and MAP2K1\n", + "i_search = 4\n", + "Looking for paths with length: 0 for node HSPB1 and MAP2K1\n", + "i_search = 4\n", + "Looking for paths with length: 1 for node HSPB1 and MAP2K1\n", + "i_search = 4\n", + "Looking for paths with length: 2 for node HSPB1 and MAP2K1\n", + "i_search = 4\n", + "Looking for paths with length: 3 for node HSPB1 and MAP2K1\n", + "i_search = 4\n", + "Looking for paths with length: 4 for node HSPB1 and MAP2K1\n", + "looking for paths in the network with length: 0 for node HSPB1 and RPS6KA1\n", + "looking for paths in the network with length: 1 for node HSPB1 and RPS6KA1\n", + "looking for paths in the network with length: 2 for node HSPB1 and RPS6KA1\n", + "looking for paths in the network with length: 3 for node HSPB1 and RPS6KA1\n", + "looking for paths in the network with length: 4 for node HSPB1 and RPS6KA1\n", + "looking for paths in the network with length: 5 for node HSPB1 and RPS6KA1\n", + "looking for paths in the network with length: 6 for node HSPB1 and RPS6KA1\n", + "looking for paths in the network with length: 7 for node HSPB1 and RPS6KA1\n", + "looking for paths in the network with length: 8 for node HSPB1 and RPS6KA1\n", + "looking for paths in the network with length: 9 for node HSPB1 and RPS6KA1\n", + "looking for paths in the network with length: 10 for node HSPB1 and RPS6KA1\n", + "i_search = 4\n", + "Looking for paths with length: 0 for node HSPB1 and RPS6KA1\n", + "i_search = 4\n", + "Looking for paths with length: 1 for node HSPB1 and RPS6KA1\n", + "i_search = 4\n", + "Looking for paths with length: 2 for node HSPB1 and RPS6KA1\n", + "i_search = 4\n", + "Looking for paths with length: 3 for node HSPB1 and RPS6KA1\n", + "i_search = 4\n", + "Looking for paths with length: 4 for node HSPB1 and RPS6KA1\n", + "looking for paths in the network with length: 0 for node HSPB1 and CREB1\n", + "looking for paths in the network with length: 1 for node HSPB1 and CREB1\n", + "looking for paths in the network with length: 2 for node HSPB1 and CREB1\n", + "looking for paths in the network with length: 3 for node HSPB1 and CREB1\n", + "looking for paths in the network with length: 4 for node HSPB1 and CREB1\n", + "looking for paths in the network with length: 5 for node HSPB1 and CREB1\n", + "looking for paths in the network with length: 6 for node HSPB1 and CREB1\n", + "looking for paths in the network with length: 7 for node HSPB1 and CREB1\n", + "looking for paths in the network with length: 8 for node HSPB1 and CREB1\n", + "looking for paths in the network with length: 9 for node HSPB1 and CREB1\n", + "looking for paths in the network with length: 10 for node HSPB1 and CREB1\n", + "i_search = 4\n", + "Looking for paths with length: 0 for node HSPB1 and CREB1\n", + "i_search = 4\n", + "Looking for paths with length: 1 for node HSPB1 and CREB1\n", + "i_search = 4\n", + "Looking for paths with length: 2 for node HSPB1 and CREB1\n", + "i_search = 4\n", + "Looking for paths with length: 3 for node HSPB1 and CREB1\n", + "i_search = 4\n", + "Looking for paths with length: 4 for node HSPB1 and CREB1\n", + "looking for paths in the network with length: 0 for node HSPB1 and NFKBIA\n", + "looking for paths in the network with length: 1 for node HSPB1 and NFKBIA\n", + "looking for paths in the network with length: 2 for node HSPB1 and NFKBIA\n", + "looking for paths in the network with length: 3 for node HSPB1 and NFKBIA\n", + "looking for paths in the network with length: 4 for node HSPB1 and NFKBIA\n", + "looking for paths in the network with length: 5 for node HSPB1 and NFKBIA\n", + "looking for paths in the network with length: 6 for node HSPB1 and NFKBIA\n", + "looking for paths in the network with length: 7 for node HSPB1 and NFKBIA\n", + "looking for paths in the network with length: 8 for node HSPB1 and NFKBIA\n", + "looking for paths in the network with length: 9 for node HSPB1 and NFKBIA\n", + "looking for paths in the network with length: 10 for node HSPB1 and NFKBIA\n", + "i_search = 4\n", + "Looking for paths with length: 0 for node HSPB1 and NFKBIA\n", + "i_search = 4\n", + "Looking for paths with length: 1 for node HSPB1 and NFKBIA\n", + "i_search = 4\n", + "Looking for paths with length: 2 for node HSPB1 and NFKBIA\n", + "i_search = 4\n", + "Looking for paths with length: 3 for node HSPB1 and NFKBIA\n", + "i_search = 4\n", + "Looking for paths with length: 4 for node HSPB1 and NFKBIA\n", + "looking for paths in the network with length: 0 for node HSPB1 and MTOR\n", + "looking for paths in the network with length: 1 for node HSPB1 and MTOR\n", + "looking for paths in the network with length: 2 for node HSPB1 and MTOR\n", + "looking for paths in the network with length: 3 for node HSPB1 and MTOR\n", + "looking for paths in the network with length: 4 for node HSPB1 and MTOR\n", + "looking for paths in the network with length: 5 for node HSPB1 and MTOR\n", + "looking for paths in the network with length: 6 for node HSPB1 and MTOR\n", + "looking for paths in the network with length: 7 for node HSPB1 and MTOR\n", + "looking for paths in the network with length: 8 for node HSPB1 and MTOR\n", + "looking for paths in the network with length: 9 for node HSPB1 and MTOR\n", + "looking for paths in the network with length: 10 for node HSPB1 and MTOR\n", + "i_search = 4\n", + "Looking for paths with length: 0 for node HSPB1 and MTOR\n", + "i_search = 4\n", + "Looking for paths with length: 1 for node HSPB1 and MTOR\n", + "i_search = 4\n", + "Looking for paths with length: 2 for node HSPB1 and MTOR\n", + "i_search = 4\n", + "Looking for paths with length: 3 for node HSPB1 and MTOR\n", + "i_search = 4\n", + "Looking for paths with length: 4 for node HSPB1 and MTOR\n", + "looking for paths in the network with length: 0 for node HSPB1 and JUN\n", + "looking for paths in the network with length: 1 for node HSPB1 and JUN\n", + "looking for paths in the network with length: 2 for node HSPB1 and JUN\n", + "looking for paths in the network with length: 3 for node HSPB1 and JUN\n", + "looking for paths in the network with length: 4 for node HSPB1 and JUN\n", + "looking for paths in the network with length: 5 for node HSPB1 and JUN\n", + "looking for paths in the network with length: 6 for node HSPB1 and JUN\n", + "looking for paths in the network with length: 7 for node HSPB1 and JUN\n", + "looking for paths in the network with length: 8 for node HSPB1 and JUN\n", + "looking for paths in the network with length: 9 for node HSPB1 and JUN\n", + "looking for paths in the network with length: 10 for node HSPB1 and JUN\n", + "i_search = 4\n", + "Looking for paths with length: 0 for node HSPB1 and JUN\n", + "i_search = 4\n", + "Looking for paths with length: 1 for node HSPB1 and JUN\n", + "i_search = 4\n", + "Looking for paths with length: 2 for node HSPB1 and JUN\n", + "i_search = 4\n", + "Looking for paths with length: 3 for node HSPB1 and JUN\n", + "i_search = 4\n", + "Looking for paths with length: 4 for node HSPB1 and JUN\n", + "looking for paths in the network with length: 0 for node HSPB1 and EGFR\n", + "looking for paths in the network with length: 1 for node HSPB1 and EGFR\n", + "looking for paths in the network with length: 2 for node HSPB1 and EGFR\n", + "looking for paths in the network with length: 3 for node HSPB1 and EGFR\n", + "looking for paths in the network with length: 4 for node HSPB1 and EGFR\n", + "looking for paths in the network with length: 5 for node HSPB1 and EGFR\n", + "looking for paths in the network with length: 6 for node HSPB1 and EGFR\n", + "looking for paths in the network with length: 7 for node HSPB1 and EGFR\n", + "looking for paths in the network with length: 8 for node HSPB1 and EGFR\n", + "looking for paths in the network with length: 9 for node HSPB1 and EGFR\n", + "looking for paths in the network with length: 10 for node HSPB1 and EGFR\n", + "i_search = 4\n", + "Looking for paths with length: 0 for node HSPB1 and EGFR\n", + "i_search = 4\n", + "Looking for paths with length: 1 for node HSPB1 and EGFR\n", + "i_search = 4\n", + "Looking for paths with length: 2 for node HSPB1 and EGFR\n", + "i_search = 4\n", + "Looking for paths with length: 3 for node HSPB1 and EGFR\n", + "i_search = 4\n", + "Looking for paths with length: 4 for node HSPB1 and EGFR\n", + "looking for paths in the network with length: 0 for node HSPB1 and MAPK3\n", + "looking for paths in the network with length: 1 for node HSPB1 and MAPK3\n", + "looking for paths in the network with length: 2 for node HSPB1 and MAPK3\n", + "looking for paths in the network with length: 3 for node HSPB1 and MAPK3\n", + "looking for paths in the network with length: 4 for node HSPB1 and MAPK3\n", + "looking for paths in the network with length: 5 for node HSPB1 and MAPK3\n", + "looking for paths in the network with length: 6 for node HSPB1 and MAPK3\n", + "looking for paths in the network with length: 7 for node HSPB1 and MAPK3\n", + "looking for paths in the network with length: 8 for node HSPB1 and MAPK3\n", + "looking for paths in the network with length: 9 for node HSPB1 and MAPK3\n", + "looking for paths in the network with length: 10 for node HSPB1 and MAPK3\n", + "i_search = 4\n", + "Looking for paths with length: 0 for node HSPB1 and MAPK3\n", + "i_search = 4\n", + "Looking for paths with length: 1 for node HSPB1 and MAPK3\n", + "i_search = 4\n", + "Looking for paths with length: 2 for node HSPB1 and MAPK3\n", + "i_search = 4\n", + "Looking for paths with length: 3 for node HSPB1 and MAPK3\n", + "i_search = 4\n", + "Looking for paths with length: 4 for node HSPB1 and MAPK3\n", + "looking for paths in the network with length: 0 for node HSPB1 and PTPN11\n", + "looking for paths in the network with length: 1 for node HSPB1 and PTPN11\n", + "looking for paths in the network with length: 2 for node HSPB1 and PTPN11\n", + "looking for paths in the network with length: 3 for node HSPB1 and PTPN11\n", + "looking for paths in the network with length: 4 for node HSPB1 and PTPN11\n", + "looking for paths in the network with length: 5 for node HSPB1 and PTPN11\n", + "looking for paths in the network with length: 6 for node HSPB1 and PTPN11\n", + "looking for paths in the network with length: 7 for node HSPB1 and PTPN11\n", + "looking for paths in the network with length: 8 for node HSPB1 and PTPN11\n", + "looking for paths in the network with length: 9 for node HSPB1 and PTPN11\n", + "looking for paths in the network with length: 10 for node HSPB1 and PTPN11\n", + "i_search = 4\n", + "Looking for paths with length: 0 for node HSPB1 and PTPN11\n", + "i_search = 4\n", + "Looking for paths with length: 1 for node HSPB1 and PTPN11\n", + "i_search = 4\n", + "Looking for paths with length: 2 for node HSPB1 and PTPN11\n", + "i_search = 4\n", + "Looking for paths with length: 3 for node HSPB1 and PTPN11\n", + "i_search = 4\n", + "Looking for paths with length: 4 for node HSPB1 and PTPN11\n", + "looking for paths in the network with length: 0 for node HSPB1 and STAT3\n", + "looking for paths in the network with length: 1 for node HSPB1 and STAT3\n", + "looking for paths in the network with length: 2 for node HSPB1 and STAT3\n", + "looking for paths in the network with length: 3 for node HSPB1 and STAT3\n", + "looking for paths in the network with length: 4 for node HSPB1 and STAT3\n", + "looking for paths in the network with length: 5 for node HSPB1 and STAT3\n", + "looking for paths in the network with length: 6 for node HSPB1 and STAT3\n", + "looking for paths in the network with length: 7 for node HSPB1 and STAT3\n", + "looking for paths in the network with length: 8 for node HSPB1 and STAT3\n", + "looking for paths in the network with length: 9 for node HSPB1 and STAT3\n", + "looking for paths in the network with length: 10 for node HSPB1 and STAT3\n", + "i_search = 4\n", + "Looking for paths with length: 0 for node HSPB1 and STAT3\n", + "i_search = 4\n", + "Looking for paths with length: 1 for node HSPB1 and STAT3\n", + "i_search = 4\n", + "Looking for paths with length: 2 for node HSPB1 and STAT3\n", + "i_search = 4\n", + "Looking for paths with length: 3 for node HSPB1 and STAT3\n", + "i_search = 4\n", + "Looking for paths with length: 4 for node HSPB1 and STAT3\n", + "looking for paths in the network with length: 0 for node HSPB1 and CHEK2\n", + "looking for paths in the network with length: 1 for node HSPB1 and CHEK2\n", + "looking for paths in the network with length: 2 for node HSPB1 and CHEK2\n", + "looking for paths in the network with length: 3 for node HSPB1 and CHEK2\n", + "looking for paths in the network with length: 4 for node HSPB1 and CHEK2\n", + "looking for paths in the network with length: 5 for node HSPB1 and CHEK2\n", + "looking for paths in the network with length: 6 for node HSPB1 and CHEK2\n", + "looking for paths in the network with length: 7 for node HSPB1 and CHEK2\n", + "looking for paths in the network with length: 8 for node HSPB1 and CHEK2\n", + "looking for paths in the network with length: 9 for node HSPB1 and CHEK2\n", + "looking for paths in the network with length: 10 for node HSPB1 and CHEK2\n", + "i_search = 4\n", + "Looking for paths with length: 0 for node HSPB1 and CHEK2\n", + "i_search = 4\n", + "Looking for paths with length: 1 for node HSPB1 and CHEK2\n", + "i_search = 4\n", + "Looking for paths with length: 2 for node HSPB1 and CHEK2\n", + "i_search = 4\n", + "Looking for paths with length: 3 for node HSPB1 and CHEK2\n", + "i_search = 4\n", + "Looking for paths with length: 4 for node HSPB1 and CHEK2\n", + "looking for paths in the network with length: 0 for node HSPB1 and RELA\n", + "looking for paths in the network with length: 1 for node HSPB1 and RELA\n", + "looking for paths in the network with length: 2 for node HSPB1 and RELA\n", + "looking for paths in the network with length: 3 for node HSPB1 and RELA\n", + "looking for paths in the network with length: 4 for node HSPB1 and RELA\n", + "looking for paths in the network with length: 5 for node HSPB1 and RELA\n", + "looking for paths in the network with length: 6 for node HSPB1 and RELA\n", + "looking for paths in the network with length: 7 for node HSPB1 and RELA\n", + "looking for paths in the network with length: 8 for node HSPB1 and RELA\n", + "looking for paths in the network with length: 9 for node HSPB1 and RELA\n", + "looking for paths in the network with length: 10 for node HSPB1 and RELA\n", + "i_search = 4\n", + "Looking for paths with length: 0 for node HSPB1 and RELA\n", + "i_search = 4\n", + "Looking for paths with length: 1 for node HSPB1 and RELA\n", + "i_search = 4\n", + "Looking for paths with length: 2 for node HSPB1 and RELA\n", + "i_search = 4\n", + "Looking for paths with length: 3 for node HSPB1 and RELA\n", + "i_search = 4\n", + "Looking for paths with length: 4 for node HSPB1 and RELA\n", + "looking for paths in the network with length: 0 for node HSPB1 and MARCKS\n", + "looking for paths in the network with length: 1 for node HSPB1 and MARCKS\n", + "looking for paths in the network with length: 2 for node HSPB1 and MARCKS\n", + "looking for paths in the network with length: 3 for node HSPB1 and MARCKS\n", + "looking for paths in the network with length: 4 for node HSPB1 and MARCKS\n", + "looking for paths in the network with length: 5 for node HSPB1 and MARCKS\n", + "looking for paths in the network with length: 6 for node HSPB1 and MARCKS\n", + "looking for paths in the network with length: 7 for node HSPB1 and MARCKS\n", + "looking for paths in the network with length: 8 for node HSPB1 and MARCKS\n", + "looking for paths in the network with length: 9 for node HSPB1 and MARCKS\n", + "looking for paths in the network with length: 10 for node HSPB1 and MARCKS\n", + "i_search = 4\n", + "Looking for paths with length: 0 for node HSPB1 and MARCKS\n", + "i_search = 4\n", + "Looking for paths with length: 1 for node HSPB1 and MARCKS\n", + "i_search = 4\n", + "Looking for paths with length: 2 for node HSPB1 and MARCKS\n", + "i_search = 4\n", + "Looking for paths with length: 3 for node HSPB1 and MARCKS\n", + "i_search = 4\n", + "Looking for paths with length: 4 for node HSPB1 and MARCKS\n", + "looking for paths in the network with length: 0 for node MAPK14 and MAP2K1\n", + "looking for paths in the network with length: 1 for node MAPK14 and MAP2K1\n", + "looking for paths in the network with length: 2 for node MAPK14 and MAP2K1\n", + "looking for paths in the network with length: 3 for node MAPK14 and MAP2K1\n", + "looking for paths in the network with length: 4 for node MAPK14 and MAP2K1\n", + "looking for paths in the network with length: 5 for node MAPK14 and MAP2K1\n", + "looking for paths in the network with length: 6 for node MAPK14 and MAP2K1\n", + "looking for paths in the network with length: 7 for node MAPK14 and MAP2K1\n", + "looking for paths in the network with length: 8 for node MAPK14 and MAP2K1\n", + "looking for paths in the network with length: 9 for node MAPK14 and MAP2K1\n", + "looking for paths in the network with length: 10 for node MAPK14 and MAP2K1\n", + "i_search = 4\n", + "Looking for paths with length: 0 for node MAPK14 and MAP2K1\n", + "i_search = 4\n", + "Looking for paths with length: 1 for node MAPK14 and MAP2K1\n", + "i_search = 4\n", + "Looking for paths with length: 2 for node MAPK14 and MAP2K1\n", + "i_search = 4\n", + "Looking for paths with length: 3 for node MAPK14 and MAP2K1\n", + "i_search = 4\n", + "Looking for paths with length: 4 for node MAPK14 and MAP2K1\n", + "looking for paths in the network with length: 0 for node MAPK14 and RPS6KA1\n", + "looking for paths in the network with length: 1 for node MAPK14 and RPS6KA1\n", + "looking for paths in the network with length: 2 for node MAPK14 and RPS6KA1\n", + "looking for paths in the network with length: 3 for node MAPK14 and RPS6KA1\n", + "looking for paths in the network with length: 4 for node MAPK14 and RPS6KA1\n", + "looking for paths in the network with length: 5 for node MAPK14 and RPS6KA1\n", + "looking for paths in the network with length: 6 for node MAPK14 and RPS6KA1\n", + "looking for paths in the network with length: 7 for node MAPK14 and RPS6KA1\n", + "looking for paths in the network with length: 8 for node MAPK14 and RPS6KA1\n", + "looking for paths in the network with length: 9 for node MAPK14 and RPS6KA1\n", + "looking for paths in the network with length: 10 for node MAPK14 and RPS6KA1\n", + "i_search = 4\n", + "Looking for paths with length: 0 for node MAPK14 and RPS6KA1\n", + "i_search = 4\n", + "Looking for paths with length: 1 for node MAPK14 and RPS6KA1\n", + "i_search = 4\n", + "Looking for paths with length: 2 for node MAPK14 and RPS6KA1\n", + "i_search = 4\n", + "Looking for paths with length: 3 for node MAPK14 and RPS6KA1\n", + "i_search = 4\n", + "Looking for paths with length: 4 for node MAPK14 and RPS6KA1\n", + "looking for paths in the network with length: 0 for node MAPK14 and CREB1\n", + "looking for paths in the network with length: 1 for node MAPK14 and CREB1\n", + "looking for paths in the network with length: 2 for node MAPK14 and CREB1\n", + "looking for paths in the network with length: 3 for node MAPK14 and CREB1\n", + "looking for paths in the network with length: 4 for node MAPK14 and CREB1\n", + "looking for paths in the network with length: 5 for node MAPK14 and CREB1\n", + "looking for paths in the network with length: 6 for node MAPK14 and CREB1\n", + "looking for paths in the network with length: 7 for node MAPK14 and CREB1\n", + "looking for paths in the network with length: 8 for node MAPK14 and CREB1\n", + "looking for paths in the network with length: 9 for node MAPK14 and CREB1\n", + "looking for paths in the network with length: 10 for node MAPK14 and CREB1\n", + "i_search = 4\n", + "Looking for paths with length: 0 for node MAPK14 and CREB1\n", + "i_search = 4\n", + "Looking for paths with length: 1 for node MAPK14 and CREB1\n", + "i_search = 4\n", + "Looking for paths with length: 2 for node MAPK14 and CREB1\n", + "i_search = 4\n", + "Looking for paths with length: 3 for node MAPK14 and CREB1\n", + "i_search = 4\n", + "Looking for paths with length: 4 for node MAPK14 and CREB1\n", + "looking for paths in the network with length: 0 for node MAPK14 and NFKBIA\n", + "looking for paths in the network with length: 1 for node MAPK14 and NFKBIA\n", + "looking for paths in the network with length: 2 for node MAPK14 and NFKBIA\n", + "looking for paths in the network with length: 3 for node MAPK14 and NFKBIA\n", + "looking for paths in the network with length: 4 for node MAPK14 and NFKBIA\n", + "looking for paths in the network with length: 5 for node MAPK14 and NFKBIA\n", + "looking for paths in the network with length: 6 for node MAPK14 and NFKBIA\n", + "looking for paths in the network with length: 7 for node MAPK14 and NFKBIA\n", + "looking for paths in the network with length: 8 for node MAPK14 and NFKBIA\n", + "looking for paths in the network with length: 9 for node MAPK14 and NFKBIA\n", + "looking for paths in the network with length: 10 for node MAPK14 and NFKBIA\n", + "i_search = 4\n", + "Looking for paths with length: 0 for node MAPK14 and NFKBIA\n", + "i_search = 4\n", + "Looking for paths with length: 1 for node MAPK14 and NFKBIA\n", + "i_search = 4\n", + "Looking for paths with length: 2 for node MAPK14 and NFKBIA\n", + "i_search = 4\n", + "Looking for paths with length: 3 for node MAPK14 and NFKBIA\n", + "i_search = 4\n", + "Looking for paths with length: 4 for node MAPK14 and NFKBIA\n", + "looking for paths in the network with length: 0 for node MAPK14 and MTOR\n", + "looking for paths in the network with length: 1 for node MAPK14 and MTOR\n", + "looking for paths in the network with length: 2 for node MAPK14 and MTOR\n", + "looking for paths in the network with length: 3 for node MAPK14 and MTOR\n", + "looking for paths in the network with length: 4 for node MAPK14 and MTOR\n", + "looking for paths in the network with length: 5 for node MAPK14 and MTOR\n", + "looking for paths in the network with length: 6 for node MAPK14 and MTOR\n", + "looking for paths in the network with length: 7 for node MAPK14 and MTOR\n", + "looking for paths in the network with length: 8 for node MAPK14 and MTOR\n", + "looking for paths in the network with length: 9 for node MAPK14 and MTOR\n", + "looking for paths in the network with length: 10 for node MAPK14 and MTOR\n", + "i_search = 4\n", + "Looking for paths with length: 0 for node MAPK14 and MTOR\n", + "i_search = 4\n", + "Looking for paths with length: 1 for node MAPK14 and MTOR\n", + "i_search = 4\n", + "Looking for paths with length: 2 for node MAPK14 and MTOR\n", + "i_search = 4\n", + "Looking for paths with length: 3 for node MAPK14 and MTOR\n", + "i_search = 4\n", + "Looking for paths with length: 4 for node MAPK14 and MTOR\n", + "looking for paths in the network with length: 0 for node MAPK14 and JUN\n", + "looking for paths in the network with length: 1 for node MAPK14 and JUN\n", + "looking for paths in the network with length: 2 for node MAPK14 and JUN\n", + "looking for paths in the network with length: 3 for node MAPK14 and JUN\n", + "looking for paths in the network with length: 4 for node MAPK14 and JUN\n", + "looking for paths in the network with length: 5 for node MAPK14 and JUN\n", + "looking for paths in the network with length: 6 for node MAPK14 and JUN\n", + "looking for paths in the network with length: 7 for node MAPK14 and JUN\n", + "looking for paths in the network with length: 8 for node MAPK14 and JUN\n", + "looking for paths in the network with length: 9 for node MAPK14 and JUN\n", + "looking for paths in the network with length: 10 for node MAPK14 and JUN\n", + "i_search = 4\n", + "Looking for paths with length: 0 for node MAPK14 and JUN\n", + "i_search = 4\n", + "Looking for paths with length: 1 for node MAPK14 and JUN\n", + "i_search = 4\n", + "Looking for paths with length: 2 for node MAPK14 and JUN\n", + "i_search = 4\n", + "Looking for paths with length: 3 for node MAPK14 and JUN\n", + "i_search = 4\n", + "Looking for paths with length: 4 for node MAPK14 and JUN\n", + "looking for paths in the network with length: 0 for node MAPK14 and EGFR\n", + "looking for paths in the network with length: 1 for node MAPK14 and EGFR\n", + "looking for paths in the network with length: 2 for node MAPK14 and EGFR\n", + "looking for paths in the network with length: 3 for node MAPK14 and EGFR\n", + "looking for paths in the network with length: 4 for node MAPK14 and EGFR\n", + "looking for paths in the network with length: 5 for node MAPK14 and EGFR\n", + "looking for paths in the network with length: 6 for node MAPK14 and EGFR\n", + "looking for paths in the network with length: 7 for node MAPK14 and EGFR\n", + "looking for paths in the network with length: 8 for node MAPK14 and EGFR\n", + "looking for paths in the network with length: 9 for node MAPK14 and EGFR\n", + "looking for paths in the network with length: 10 for node MAPK14 and EGFR\n", + "i_search = 4\n", + "Looking for paths with length: 0 for node MAPK14 and EGFR\n", + "i_search = 4\n", + "Looking for paths with length: 1 for node MAPK14 and EGFR\n", + "i_search = 4\n", + "Looking for paths with length: 2 for node MAPK14 and EGFR\n", + "i_search = 4\n", + "Looking for paths with length: 3 for node MAPK14 and EGFR\n", + "i_search = 4\n", + "Looking for paths with length: 4 for node MAPK14 and EGFR\n", + "looking for paths in the network with length: 0 for node MAPK14 and MAPK3\n", + "looking for paths in the network with length: 1 for node MAPK14 and MAPK3\n", + "looking for paths in the network with length: 2 for node MAPK14 and MAPK3\n", + "looking for paths in the network with length: 3 for node MAPK14 and MAPK3\n", + "looking for paths in the network with length: 4 for node MAPK14 and MAPK3\n", + "looking for paths in the network with length: 5 for node MAPK14 and MAPK3\n", + "looking for paths in the network with length: 6 for node MAPK14 and MAPK3\n", + "looking for paths in the network with length: 7 for node MAPK14 and MAPK3\n", + "looking for paths in the network with length: 8 for node MAPK14 and MAPK3\n", + "looking for paths in the network with length: 9 for node MAPK14 and MAPK3\n", + "looking for paths in the network with length: 10 for node MAPK14 and MAPK3\n", + "i_search = 4\n", + "Looking for paths with length: 0 for node MAPK14 and MAPK3\n", + "i_search = 4\n", + "Looking for paths with length: 1 for node MAPK14 and MAPK3\n", + "i_search = 4\n", + "Looking for paths with length: 2 for node MAPK14 and MAPK3\n", + "i_search = 4\n", + "Looking for paths with length: 3 for node MAPK14 and MAPK3\n", + "i_search = 4\n", + "Looking for paths with length: 4 for node MAPK14 and MAPK3\n", + "looking for paths in the network with length: 0 for node MAPK14 and PTPN11\n", + "looking for paths in the network with length: 1 for node MAPK14 and PTPN11\n", + "looking for paths in the network with length: 2 for node MAPK14 and PTPN11\n", + "looking for paths in the network with length: 3 for node MAPK14 and PTPN11\n", + "looking for paths in the network with length: 4 for node MAPK14 and PTPN11\n", + "looking for paths in the network with length: 5 for node MAPK14 and PTPN11\n", + "looking for paths in the network with length: 6 for node MAPK14 and PTPN11\n", + "looking for paths in the network with length: 7 for node MAPK14 and PTPN11\n", + "looking for paths in the network with length: 8 for node MAPK14 and PTPN11\n", + "looking for paths in the network with length: 9 for node MAPK14 and PTPN11\n", + "looking for paths in the network with length: 10 for node MAPK14 and PTPN11\n", + "i_search = 4\n", + "Looking for paths with length: 0 for node MAPK14 and PTPN11\n", + "i_search = 4\n", + "Looking for paths with length: 1 for node MAPK14 and PTPN11\n", + "i_search = 4\n", + "Looking for paths with length: 2 for node MAPK14 and PTPN11\n", + "i_search = 4\n", + "Looking for paths with length: 3 for node MAPK14 and PTPN11\n", + "i_search = 4\n", + "Looking for paths with length: 4 for node MAPK14 and PTPN11\n", + "looking for paths in the network with length: 0 for node MAPK14 and STAT3\n", + "looking for paths in the network with length: 1 for node MAPK14 and STAT3\n", + "looking for paths in the network with length: 2 for node MAPK14 and STAT3\n", + "looking for paths in the network with length: 3 for node MAPK14 and STAT3\n", + "looking for paths in the network with length: 4 for node MAPK14 and STAT3\n", + "looking for paths in the network with length: 5 for node MAPK14 and STAT3\n", + "looking for paths in the network with length: 6 for node MAPK14 and STAT3\n", + "looking for paths in the network with length: 7 for node MAPK14 and STAT3\n", + "looking for paths in the network with length: 8 for node MAPK14 and STAT3\n", + "looking for paths in the network with length: 9 for node MAPK14 and STAT3\n", + "looking for paths in the network with length: 10 for node MAPK14 and STAT3\n", + "i_search = 4\n", + "Looking for paths with length: 0 for node MAPK14 and STAT3\n", + "i_search = 4\n", + "Looking for paths with length: 1 for node MAPK14 and STAT3\n", + "i_search = 4\n", + "Looking for paths with length: 2 for node MAPK14 and STAT3\n", + "i_search = 4\n", + "Looking for paths with length: 3 for node MAPK14 and STAT3\n", + "i_search = 4\n", + "Looking for paths with length: 4 for node MAPK14 and STAT3\n", + "looking for paths in the network with length: 0 for node MAPK14 and CHEK2\n", + "looking for paths in the network with length: 1 for node MAPK14 and CHEK2\n", + "looking for paths in the network with length: 2 for node MAPK14 and CHEK2\n", + "looking for paths in the network with length: 3 for node MAPK14 and CHEK2\n", + "looking for paths in the network with length: 4 for node MAPK14 and CHEK2\n", + "looking for paths in the network with length: 5 for node MAPK14 and CHEK2\n", + "looking for paths in the network with length: 6 for node MAPK14 and CHEK2\n", + "looking for paths in the network with length: 7 for node MAPK14 and CHEK2\n", + "looking for paths in the network with length: 8 for node MAPK14 and CHEK2\n", + "looking for paths in the network with length: 9 for node MAPK14 and CHEK2\n", + "looking for paths in the network with length: 10 for node MAPK14 and CHEK2\n", + "i_search = 4\n", + "Looking for paths with length: 0 for node MAPK14 and CHEK2\n", + "i_search = 4\n", + "Looking for paths with length: 1 for node MAPK14 and CHEK2\n", + "i_search = 4\n", + "Looking for paths with length: 2 for node MAPK14 and CHEK2\n", + "i_search = 4\n", + "Looking for paths with length: 3 for node MAPK14 and CHEK2\n", + "i_search = 4\n", + "Looking for paths with length: 4 for node MAPK14 and CHEK2\n", + "looking for paths in the network with length: 0 for node MAPK14 and RELA\n", + "looking for paths in the network with length: 1 for node MAPK14 and RELA\n", + "looking for paths in the network with length: 2 for node MAPK14 and RELA\n", + "looking for paths in the network with length: 3 for node MAPK14 and RELA\n", + "looking for paths in the network with length: 4 for node MAPK14 and RELA\n", + "looking for paths in the network with length: 5 for node MAPK14 and RELA\n", + "looking for paths in the network with length: 6 for node MAPK14 and RELA\n", + "looking for paths in the network with length: 7 for node MAPK14 and RELA\n", + "looking for paths in the network with length: 8 for node MAPK14 and RELA\n", + "looking for paths in the network with length: 9 for node MAPK14 and RELA\n", + "looking for paths in the network with length: 10 for node MAPK14 and RELA\n", + "i_search = 4\n", + "Looking for paths with length: 0 for node MAPK14 and RELA\n", + "i_search = 4\n", + "Looking for paths with length: 1 for node MAPK14 and RELA\n", + "i_search = 4\n", + "Looking for paths with length: 2 for node MAPK14 and RELA\n", + "i_search = 4\n", + "Looking for paths with length: 3 for node MAPK14 and RELA\n", + "i_search = 4\n", + "Looking for paths with length: 4 for node MAPK14 and RELA\n", + "looking for paths in the network with length: 0 for node MAPK14 and MARCKS\n", + "looking for paths in the network with length: 1 for node MAPK14 and MARCKS\n", + "looking for paths in the network with length: 2 for node MAPK14 and MARCKS\n", + "looking for paths in the network with length: 3 for node MAPK14 and MARCKS\n", + "looking for paths in the network with length: 4 for node MAPK14 and MARCKS\n", + "looking for paths in the network with length: 5 for node MAPK14 and MARCKS\n", + "looking for paths in the network with length: 6 for node MAPK14 and MARCKS\n", + "looking for paths in the network with length: 7 for node MAPK14 and MARCKS\n", + "looking for paths in the network with length: 8 for node MAPK14 and MARCKS\n", + "looking for paths in the network with length: 9 for node MAPK14 and MARCKS\n", + "looking for paths in the network with length: 10 for node MAPK14 and MARCKS\n", + "i_search = 4\n", + "Looking for paths with length: 0 for node MAPK14 and MARCKS\n", + "i_search = 4\n", + "Looking for paths with length: 1 for node MAPK14 and MARCKS\n", + "i_search = 4\n", + "Looking for paths with length: 2 for node MAPK14 and MARCKS\n", + "i_search = 4\n", + "Looking for paths with length: 3 for node MAPK14 and MARCKS\n", + "i_search = 4\n", + "Looking for paths with length: 4 for node MAPK14 and MARCKS\n", + "looking for paths in the network with length: 0 for node MAP2K1 and RPS6KA1\n", + "looking for paths in the network with length: 1 for node MAP2K1 and RPS6KA1\n", + "looking for paths in the network with length: 2 for node MAP2K1 and RPS6KA1\n", + "looking for paths in the network with length: 3 for node MAP2K1 and RPS6KA1\n", + "looking for paths in the network with length: 4 for node MAP2K1 and RPS6KA1\n", + "looking for paths in the network with length: 5 for node MAP2K1 and RPS6KA1\n", + "looking for paths in the network with length: 6 for node MAP2K1 and RPS6KA1\n", + "looking for paths in the network with length: 7 for node MAP2K1 and RPS6KA1\n", + "looking for paths in the network with length: 8 for node MAP2K1 and RPS6KA1\n", + "looking for paths in the network with length: 9 for node MAP2K1 and RPS6KA1\n", + "looking for paths in the network with length: 10 for node MAP2K1 and RPS6KA1\n", + "i_search = 4\n", + "Looking for paths with length: 0 for node MAP2K1 and RPS6KA1\n", + "i_search = 4\n", + "Looking for paths with length: 1 for node MAP2K1 and RPS6KA1\n", + "i_search = 4\n", + "Looking for paths with length: 2 for node MAP2K1 and RPS6KA1\n", + "i_search = 4\n", + "Looking for paths with length: 3 for node MAP2K1 and RPS6KA1\n", + "i_search = 4\n", + "Looking for paths with length: 4 for node MAP2K1 and RPS6KA1\n", + "looking for paths in the network with length: 0 for node MAP2K1 and CREB1\n", + "looking for paths in the network with length: 1 for node MAP2K1 and CREB1\n", + "looking for paths in the network with length: 2 for node MAP2K1 and CREB1\n", + "looking for paths in the network with length: 3 for node MAP2K1 and CREB1\n", + "looking for paths in the network with length: 4 for node MAP2K1 and CREB1\n", + "looking for paths in the network with length: 5 for node MAP2K1 and CREB1\n", + "looking for paths in the network with length: 6 for node MAP2K1 and CREB1\n", + "looking for paths in the network with length: 7 for node MAP2K1 and CREB1\n", + "looking for paths in the network with length: 8 for node MAP2K1 and CREB1\n", + "looking for paths in the network with length: 9 for node MAP2K1 and CREB1\n", + "looking for paths in the network with length: 10 for node MAP2K1 and CREB1\n", + "i_search = 4\n", + "Looking for paths with length: 0 for node MAP2K1 and CREB1\n", + "i_search = 4\n", + "Looking for paths with length: 1 for node MAP2K1 and CREB1\n", + "i_search = 4\n", + "Looking for paths with length: 2 for node MAP2K1 and CREB1\n", + "i_search = 4\n", + "Looking for paths with length: 3 for node MAP2K1 and CREB1\n", + "i_search = 4\n", + "Looking for paths with length: 4 for node MAP2K1 and CREB1\n", + "looking for paths in the network with length: 0 for node MAP2K1 and NFKBIA\n", + "looking for paths in the network with length: 1 for node MAP2K1 and NFKBIA\n", + "looking for paths in the network with length: 2 for node MAP2K1 and NFKBIA\n", + "looking for paths in the network with length: 3 for node MAP2K1 and NFKBIA\n", + "looking for paths in the network with length: 4 for node MAP2K1 and NFKBIA\n", + "looking for paths in the network with length: 5 for node MAP2K1 and NFKBIA\n", + "looking for paths in the network with length: 6 for node MAP2K1 and NFKBIA\n", + "looking for paths in the network with length: 7 for node MAP2K1 and NFKBIA\n", + "looking for paths in the network with length: 8 for node MAP2K1 and NFKBIA\n", + "looking for paths in the network with length: 9 for node MAP2K1 and NFKBIA\n", + "looking for paths in the network with length: 10 for node MAP2K1 and NFKBIA\n", + "i_search = 4\n", + "Looking for paths with length: 0 for node MAP2K1 and NFKBIA\n", + "i_search = 4\n", + "Looking for paths with length: 1 for node MAP2K1 and NFKBIA\n", + "i_search = 4\n", + "Looking for paths with length: 2 for node MAP2K1 and NFKBIA\n", + "i_search = 4\n", + "Looking for paths with length: 3 for node MAP2K1 and NFKBIA\n", + "i_search = 4\n", + "Looking for paths with length: 4 for node MAP2K1 and NFKBIA\n", + "looking for paths in the network with length: 0 for node MAP2K1 and MTOR\n", + "looking for paths in the network with length: 1 for node MAP2K1 and MTOR\n", + "looking for paths in the network with length: 2 for node MAP2K1 and MTOR\n", + "looking for paths in the network with length: 3 for node MAP2K1 and MTOR\n", + "looking for paths in the network with length: 4 for node MAP2K1 and MTOR\n", + "looking for paths in the network with length: 5 for node MAP2K1 and MTOR\n", + "looking for paths in the network with length: 6 for node MAP2K1 and MTOR\n", + "looking for paths in the network with length: 7 for node MAP2K1 and MTOR\n", + "looking for paths in the network with length: 8 for node MAP2K1 and MTOR\n", + "looking for paths in the network with length: 9 for node MAP2K1 and MTOR\n", + "looking for paths in the network with length: 10 for node MAP2K1 and MTOR\n", + "i_search = 4\n", + "Looking for paths with length: 0 for node MAP2K1 and MTOR\n", + "i_search = 4\n", + "Looking for paths with length: 1 for node MAP2K1 and MTOR\n", + "i_search = 4\n", + "Looking for paths with length: 2 for node MAP2K1 and MTOR\n", + "i_search = 4\n", + "Looking for paths with length: 3 for node MAP2K1 and MTOR\n", + "i_search = 4\n", + "Looking for paths with length: 4 for node MAP2K1 and MTOR\n", + "looking for paths in the network with length: 0 for node MAP2K1 and JUN\n", + "looking for paths in the network with length: 1 for node MAP2K1 and JUN\n", + "looking for paths in the network with length: 2 for node MAP2K1 and JUN\n", + "looking for paths in the network with length: 3 for node MAP2K1 and JUN\n", + "looking for paths in the network with length: 4 for node MAP2K1 and JUN\n", + "looking for paths in the network with length: 5 for node MAP2K1 and JUN\n", + "looking for paths in the network with length: 6 for node MAP2K1 and JUN\n", + "looking for paths in the network with length: 7 for node MAP2K1 and JUN\n", + "looking for paths in the network with length: 8 for node MAP2K1 and JUN\n", + "looking for paths in the network with length: 9 for node MAP2K1 and JUN\n", + "looking for paths in the network with length: 10 for node MAP2K1 and JUN\n", + "i_search = 4\n", + "Looking for paths with length: 0 for node MAP2K1 and JUN\n", + "i_search = 4\n", + "Looking for paths with length: 1 for node MAP2K1 and JUN\n", + "i_search = 4\n", + "Looking for paths with length: 2 for node MAP2K1 and JUN\n", + "i_search = 4\n", + "Looking for paths with length: 3 for node MAP2K1 and JUN\n", + "i_search = 4\n", + "Looking for paths with length: 4 for node MAP2K1 and JUN\n", + "looking for paths in the network with length: 0 for node MAP2K1 and EGFR\n", + "looking for paths in the network with length: 1 for node MAP2K1 and EGFR\n", + "looking for paths in the network with length: 2 for node MAP2K1 and EGFR\n", + "looking for paths in the network with length: 3 for node MAP2K1 and EGFR\n", + "looking for paths in the network with length: 4 for node MAP2K1 and EGFR\n", + "looking for paths in the network with length: 5 for node MAP2K1 and EGFR\n", + "looking for paths in the network with length: 6 for node MAP2K1 and EGFR\n", + "looking for paths in the network with length: 7 for node MAP2K1 and EGFR\n", + "looking for paths in the network with length: 8 for node MAP2K1 and EGFR\n", + "looking for paths in the network with length: 9 for node MAP2K1 and EGFR\n", + "looking for paths in the network with length: 10 for node MAP2K1 and EGFR\n", + "i_search = 4\n", + "Looking for paths with length: 0 for node MAP2K1 and EGFR\n", + "i_search = 4\n", + "Looking for paths with length: 1 for node MAP2K1 and EGFR\n", + "i_search = 4\n", + "Looking for paths with length: 2 for node MAP2K1 and EGFR\n", + "i_search = 4\n", + "Looking for paths with length: 3 for node MAP2K1 and EGFR\n", + "i_search = 4\n", + "Looking for paths with length: 4 for node MAP2K1 and EGFR\n", + "looking for paths in the network with length: 0 for node MAP2K1 and MAPK3\n", + "looking for paths in the network with length: 1 for node MAP2K1 and MAPK3\n", + "looking for paths in the network with length: 2 for node MAP2K1 and MAPK3\n", + "looking for paths in the network with length: 3 for node MAP2K1 and MAPK3\n", + "looking for paths in the network with length: 4 for node MAP2K1 and MAPK3\n", + "looking for paths in the network with length: 5 for node MAP2K1 and MAPK3\n", + "looking for paths in the network with length: 6 for node MAP2K1 and MAPK3\n", + "looking for paths in the network with length: 7 for node MAP2K1 and MAPK3\n", + "looking for paths in the network with length: 8 for node MAP2K1 and MAPK3\n", + "looking for paths in the network with length: 9 for node MAP2K1 and MAPK3\n", + "looking for paths in the network with length: 10 for node MAP2K1 and MAPK3\n", + "i_search = 4\n", + "Looking for paths with length: 0 for node MAP2K1 and MAPK3\n", + "i_search = 4\n", + "Looking for paths with length: 1 for node MAP2K1 and MAPK3\n", + "i_search = 4\n", + "Looking for paths with length: 2 for node MAP2K1 and MAPK3\n", + "i_search = 4\n", + "Looking for paths with length: 3 for node MAP2K1 and MAPK3\n", + "i_search = 4\n", + "Looking for paths with length: 4 for node MAP2K1 and MAPK3\n", + "looking for paths in the network with length: 0 for node MAP2K1 and PTPN11\n", + "looking for paths in the network with length: 1 for node MAP2K1 and PTPN11\n", + "looking for paths in the network with length: 2 for node MAP2K1 and PTPN11\n", + "looking for paths in the network with length: 3 for node MAP2K1 and PTPN11\n", + "looking for paths in the network with length: 4 for node MAP2K1 and PTPN11\n", + "looking for paths in the network with length: 5 for node MAP2K1 and PTPN11\n", + "looking for paths in the network with length: 6 for node MAP2K1 and PTPN11\n", + "looking for paths in the network with length: 7 for node MAP2K1 and PTPN11\n", + "looking for paths in the network with length: 8 for node MAP2K1 and PTPN11\n", + "looking for paths in the network with length: 9 for node MAP2K1 and PTPN11\n", + "looking for paths in the network with length: 10 for node MAP2K1 and PTPN11\n", + "i_search = 4\n", + "Looking for paths with length: 0 for node MAP2K1 and PTPN11\n", + "i_search = 4\n", + "Looking for paths with length: 1 for node MAP2K1 and PTPN11\n", + "i_search = 4\n", + "Looking for paths with length: 2 for node MAP2K1 and PTPN11\n", + "i_search = 4\n", + "Looking for paths with length: 3 for node MAP2K1 and PTPN11\n", + "i_search = 4\n", + "Looking for paths with length: 4 for node MAP2K1 and PTPN11\n", + "looking for paths in the network with length: 0 for node MAP2K1 and STAT3\n", + "looking for paths in the network with length: 1 for node MAP2K1 and STAT3\n", + "looking for paths in the network with length: 2 for node MAP2K1 and STAT3\n", + "looking for paths in the network with length: 3 for node MAP2K1 and STAT3\n", + "looking for paths in the network with length: 4 for node MAP2K1 and STAT3\n", + "looking for paths in the network with length: 5 for node MAP2K1 and STAT3\n", + "looking for paths in the network with length: 6 for node MAP2K1 and STAT3\n", + "looking for paths in the network with length: 7 for node MAP2K1 and STAT3\n", + "looking for paths in the network with length: 8 for node MAP2K1 and STAT3\n", + "looking for paths in the network with length: 9 for node MAP2K1 and STAT3\n", + "looking for paths in the network with length: 10 for node MAP2K1 and STAT3\n", + "i_search = 4\n", + "Looking for paths with length: 0 for node MAP2K1 and STAT3\n", + "i_search = 4\n", + "Looking for paths with length: 1 for node MAP2K1 and STAT3\n", + "i_search = 4\n", + "Looking for paths with length: 2 for node MAP2K1 and STAT3\n", + "i_search = 4\n", + "Looking for paths with length: 3 for node MAP2K1 and STAT3\n", + "i_search = 4\n", + "Looking for paths with length: 4 for node MAP2K1 and STAT3\n", + "looking for paths in the network with length: 0 for node MAP2K1 and CHEK2\n", + "looking for paths in the network with length: 1 for node MAP2K1 and CHEK2\n", + "looking for paths in the network with length: 2 for node MAP2K1 and CHEK2\n", + "looking for paths in the network with length: 3 for node MAP2K1 and CHEK2\n", + "looking for paths in the network with length: 4 for node MAP2K1 and CHEK2\n", + "looking for paths in the network with length: 5 for node MAP2K1 and CHEK2\n", + "looking for paths in the network with length: 6 for node MAP2K1 and CHEK2\n", + "looking for paths in the network with length: 7 for node MAP2K1 and CHEK2\n", + "looking for paths in the network with length: 8 for node MAP2K1 and CHEK2\n", + "looking for paths in the network with length: 9 for node MAP2K1 and CHEK2\n", + "looking for paths in the network with length: 10 for node MAP2K1 and CHEK2\n", + "i_search = 4\n", + "Looking for paths with length: 0 for node MAP2K1 and CHEK2\n", + "i_search = 4\n", + "Looking for paths with length: 1 for node MAP2K1 and CHEK2\n", + "i_search = 4\n", + "Looking for paths with length: 2 for node MAP2K1 and CHEK2\n", + "i_search = 4\n", + "Looking for paths with length: 3 for node MAP2K1 and CHEK2\n", + "i_search = 4\n", + "Looking for paths with length: 4 for node MAP2K1 and CHEK2\n", + "looking for paths in the network with length: 0 for node MAP2K1 and RELA\n", + "looking for paths in the network with length: 1 for node MAP2K1 and RELA\n", + "looking for paths in the network with length: 2 for node MAP2K1 and RELA\n", + "looking for paths in the network with length: 3 for node MAP2K1 and RELA\n", + "looking for paths in the network with length: 4 for node MAP2K1 and RELA\n", + "looking for paths in the network with length: 5 for node MAP2K1 and RELA\n", + "looking for paths in the network with length: 6 for node MAP2K1 and RELA\n", + "looking for paths in the network with length: 7 for node MAP2K1 and RELA\n", + "looking for paths in the network with length: 8 for node MAP2K1 and RELA\n", + "looking for paths in the network with length: 9 for node MAP2K1 and RELA\n", + "looking for paths in the network with length: 10 for node MAP2K1 and RELA\n", + "i_search = 4\n", + "Looking for paths with length: 0 for node MAP2K1 and RELA\n", + "i_search = 4\n", + "Looking for paths with length: 1 for node MAP2K1 and RELA\n", + "i_search = 4\n", + "Looking for paths with length: 2 for node MAP2K1 and RELA\n", + "i_search = 4\n", + "Looking for paths with length: 3 for node MAP2K1 and RELA\n", + "i_search = 4\n", + "Looking for paths with length: 4 for node MAP2K1 and RELA\n", + "looking for paths in the network with length: 0 for node MAP2K1 and MARCKS\n", + "looking for paths in the network with length: 1 for node MAP2K1 and MARCKS\n", + "looking for paths in the network with length: 2 for node MAP2K1 and MARCKS\n", + "looking for paths in the network with length: 3 for node MAP2K1 and MARCKS\n", + "looking for paths in the network with length: 4 for node MAP2K1 and MARCKS\n", + "looking for paths in the network with length: 5 for node MAP2K1 and MARCKS\n", + "looking for paths in the network with length: 6 for node MAP2K1 and MARCKS\n", + "looking for paths in the network with length: 7 for node MAP2K1 and MARCKS\n", + "looking for paths in the network with length: 8 for node MAP2K1 and MARCKS\n", + "looking for paths in the network with length: 9 for node MAP2K1 and MARCKS\n", + "looking for paths in the network with length: 10 for node MAP2K1 and MARCKS\n", + "i_search = 4\n", + "Looking for paths with length: 0 for node MAP2K1 and MARCKS\n", + "i_search = 4\n", + "Looking for paths with length: 1 for node MAP2K1 and MARCKS\n", + "i_search = 4\n", + "Looking for paths with length: 2 for node MAP2K1 and MARCKS\n", + "i_search = 4\n", + "Looking for paths with length: 3 for node MAP2K1 and MARCKS\n", + "i_search = 4\n", + "Looking for paths with length: 4 for node MAP2K1 and MARCKS\n", + "looking for paths in the network with length: 0 for node RPS6KA1 and CREB1\n", + "looking for paths in the network with length: 1 for node RPS6KA1 and CREB1\n", + "looking for paths in the network with length: 2 for node RPS6KA1 and CREB1\n", + "looking for paths in the network with length: 3 for node RPS6KA1 and CREB1\n", + "looking for paths in the network with length: 4 for node RPS6KA1 and CREB1\n", + "looking for paths in the network with length: 5 for node RPS6KA1 and CREB1\n", + "looking for paths in the network with length: 6 for node RPS6KA1 and CREB1\n", + "looking for paths in the network with length: 7 for node RPS6KA1 and CREB1\n", + "looking for paths in the network with length: 8 for node RPS6KA1 and CREB1\n", + "looking for paths in the network with length: 9 for node RPS6KA1 and CREB1\n", + "looking for paths in the network with length: 10 for node RPS6KA1 and CREB1\n", + "i_search = 4\n", + "Looking for paths with length: 0 for node RPS6KA1 and CREB1\n", + "i_search = 4\n", + "Looking for paths with length: 1 for node RPS6KA1 and CREB1\n", + "i_search = 4\n", + "Looking for paths with length: 2 for node RPS6KA1 and CREB1\n", + "i_search = 4\n", + "Looking for paths with length: 3 for node RPS6KA1 and CREB1\n", + "i_search = 4\n", + "Looking for paths with length: 4 for node RPS6KA1 and CREB1\n", + "looking for paths in the network with length: 0 for node RPS6KA1 and NFKBIA\n", + "looking for paths in the network with length: 1 for node RPS6KA1 and NFKBIA\n", + "looking for paths in the network with length: 2 for node RPS6KA1 and NFKBIA\n", + "looking for paths in the network with length: 3 for node RPS6KA1 and NFKBIA\n", + "looking for paths in the network with length: 4 for node RPS6KA1 and NFKBIA\n", + "looking for paths in the network with length: 5 for node RPS6KA1 and NFKBIA\n", + "looking for paths in the network with length: 6 for node RPS6KA1 and NFKBIA\n", + "looking for paths in the network with length: 7 for node RPS6KA1 and NFKBIA\n", + "looking for paths in the network with length: 8 for node RPS6KA1 and NFKBIA\n", + "looking for paths in the network with length: 9 for node RPS6KA1 and NFKBIA\n", + "looking for paths in the network with length: 10 for node RPS6KA1 and NFKBIA\n", + "i_search = 4\n", + "Looking for paths with length: 0 for node RPS6KA1 and NFKBIA\n", + "i_search = 4\n", + "Looking for paths with length: 1 for node RPS6KA1 and NFKBIA\n", + "i_search = 4\n", + "Looking for paths with length: 2 for node RPS6KA1 and NFKBIA\n", + "i_search = 4\n", + "Looking for paths with length: 3 for node RPS6KA1 and NFKBIA\n", + "i_search = 4\n", + "Looking for paths with length: 4 for node RPS6KA1 and NFKBIA\n", + "looking for paths in the network with length: 0 for node RPS6KA1 and MTOR\n", + "looking for paths in the network with length: 1 for node RPS6KA1 and MTOR\n", + "looking for paths in the network with length: 2 for node RPS6KA1 and MTOR\n", + "looking for paths in the network with length: 3 for node RPS6KA1 and MTOR\n", + "looking for paths in the network with length: 4 for node RPS6KA1 and MTOR\n", + "looking for paths in the network with length: 5 for node RPS6KA1 and MTOR\n", + "looking for paths in the network with length: 6 for node RPS6KA1 and MTOR\n", + "looking for paths in the network with length: 7 for node RPS6KA1 and MTOR\n", + "looking for paths in the network with length: 8 for node RPS6KA1 and MTOR\n", + "looking for paths in the network with length: 9 for node RPS6KA1 and MTOR\n", + "looking for paths in the network with length: 10 for node RPS6KA1 and MTOR\n", + "i_search = 4\n", + "Looking for paths with length: 0 for node RPS6KA1 and MTOR\n", + "i_search = 4\n", + "Looking for paths with length: 1 for node RPS6KA1 and MTOR\n", + "i_search = 4\n", + "Looking for paths with length: 2 for node RPS6KA1 and MTOR\n", + "i_search = 4\n", + "Looking for paths with length: 3 for node RPS6KA1 and MTOR\n", + "i_search = 4\n", + "Looking for paths with length: 4 for node RPS6KA1 and MTOR\n", + "looking for paths in the network with length: 0 for node RPS6KA1 and JUN\n", + "looking for paths in the network with length: 1 for node RPS6KA1 and JUN\n", + "looking for paths in the network with length: 2 for node RPS6KA1 and JUN\n", + "looking for paths in the network with length: 3 for node RPS6KA1 and JUN\n", + "looking for paths in the network with length: 4 for node RPS6KA1 and JUN\n", + "looking for paths in the network with length: 5 for node RPS6KA1 and JUN\n", + "looking for paths in the network with length: 6 for node RPS6KA1 and JUN\n", + "looking for paths in the network with length: 7 for node RPS6KA1 and JUN\n", + "looking for paths in the network with length: 8 for node RPS6KA1 and JUN\n", + "looking for paths in the network with length: 9 for node RPS6KA1 and JUN\n", + "looking for paths in the network with length: 10 for node RPS6KA1 and JUN\n", + "i_search = 4\n", + "Looking for paths with length: 0 for node RPS6KA1 and JUN\n", + "i_search = 4\n", + "Looking for paths with length: 1 for node RPS6KA1 and JUN\n", + "i_search = 4\n", + "Looking for paths with length: 2 for node RPS6KA1 and JUN\n", + "i_search = 4\n", + "Looking for paths with length: 3 for node RPS6KA1 and JUN\n", + "i_search = 4\n", + "Looking for paths with length: 4 for node RPS6KA1 and JUN\n", + "looking for paths in the network with length: 0 for node RPS6KA1 and EGFR\n", + "looking for paths in the network with length: 1 for node RPS6KA1 and EGFR\n", + "looking for paths in the network with length: 2 for node RPS6KA1 and EGFR\n", + "looking for paths in the network with length: 3 for node RPS6KA1 and EGFR\n", + "looking for paths in the network with length: 4 for node RPS6KA1 and EGFR\n", + "looking for paths in the network with length: 5 for node RPS6KA1 and EGFR\n", + "looking for paths in the network with length: 6 for node RPS6KA1 and EGFR\n", + "looking for paths in the network with length: 7 for node RPS6KA1 and EGFR\n", + "looking for paths in the network with length: 8 for node RPS6KA1 and EGFR\n", + "looking for paths in the network with length: 9 for node RPS6KA1 and EGFR\n", + "looking for paths in the network with length: 10 for node RPS6KA1 and EGFR\n", + "i_search = 4\n", + "Looking for paths with length: 0 for node RPS6KA1 and EGFR\n", + "i_search = 4\n", + "Looking for paths with length: 1 for node RPS6KA1 and EGFR\n", + "i_search = 4\n", + "Looking for paths with length: 2 for node RPS6KA1 and EGFR\n", + "i_search = 4\n", + "Looking for paths with length: 3 for node RPS6KA1 and EGFR\n", + "i_search = 4\n", + "Looking for paths with length: 4 for node RPS6KA1 and EGFR\n", + "looking for paths in the network with length: 0 for node RPS6KA1 and MAPK3\n", + "looking for paths in the network with length: 1 for node RPS6KA1 and MAPK3\n", + "looking for paths in the network with length: 2 for node RPS6KA1 and MAPK3\n", + "looking for paths in the network with length: 3 for node RPS6KA1 and MAPK3\n", + "looking for paths in the network with length: 4 for node RPS6KA1 and MAPK3\n", + "looking for paths in the network with length: 5 for node RPS6KA1 and MAPK3\n", + "looking for paths in the network with length: 6 for node RPS6KA1 and MAPK3\n", + "looking for paths in the network with length: 7 for node RPS6KA1 and MAPK3\n", + "looking for paths in the network with length: 8 for node RPS6KA1 and MAPK3\n", + "looking for paths in the network with length: 9 for node RPS6KA1 and MAPK3\n", + "looking for paths in the network with length: 10 for node RPS6KA1 and MAPK3\n", + "i_search = 4\n", + "Looking for paths with length: 0 for node RPS6KA1 and MAPK3\n", + "i_search = 4\n", + "Looking for paths with length: 1 for node RPS6KA1 and MAPK3\n", + "i_search = 4\n", + "Looking for paths with length: 2 for node RPS6KA1 and MAPK3\n", + "i_search = 4\n", + "Looking for paths with length: 3 for node RPS6KA1 and MAPK3\n", + "i_search = 4\n", + "Looking for paths with length: 4 for node RPS6KA1 and MAPK3\n", + "looking for paths in the network with length: 0 for node RPS6KA1 and PTPN11\n", + "looking for paths in the network with length: 1 for node RPS6KA1 and PTPN11\n", + "looking for paths in the network with length: 2 for node RPS6KA1 and PTPN11\n", + "looking for paths in the network with length: 3 for node RPS6KA1 and PTPN11\n", + "looking for paths in the network with length: 4 for node RPS6KA1 and PTPN11\n", + "looking for paths in the network with length: 5 for node RPS6KA1 and PTPN11\n", + "looking for paths in the network with length: 6 for node RPS6KA1 and PTPN11\n", + "looking for paths in the network with length: 7 for node RPS6KA1 and PTPN11\n", + "looking for paths in the network with length: 8 for node RPS6KA1 and PTPN11\n", + "looking for paths in the network with length: 9 for node RPS6KA1 and PTPN11\n", + "looking for paths in the network with length: 10 for node RPS6KA1 and PTPN11\n", + "i_search = 4\n", + "Looking for paths with length: 0 for node RPS6KA1 and PTPN11\n", + "i_search = 4\n", + "Looking for paths with length: 1 for node RPS6KA1 and PTPN11\n", + "i_search = 4\n", + "Looking for paths with length: 2 for node RPS6KA1 and PTPN11\n", + "i_search = 4\n", + "Looking for paths with length: 3 for node RPS6KA1 and PTPN11\n", + "i_search = 4\n", + "Looking for paths with length: 4 for node RPS6KA1 and PTPN11\n", + "looking for paths in the network with length: 0 for node RPS6KA1 and STAT3\n", + "looking for paths in the network with length: 1 for node RPS6KA1 and STAT3\n", + "looking for paths in the network with length: 2 for node RPS6KA1 and STAT3\n", + "looking for paths in the network with length: 3 for node RPS6KA1 and STAT3\n", + "looking for paths in the network with length: 4 for node RPS6KA1 and STAT3\n", + "looking for paths in the network with length: 5 for node RPS6KA1 and STAT3\n", + "looking for paths in the network with length: 6 for node RPS6KA1 and STAT3\n", + "looking for paths in the network with length: 7 for node RPS6KA1 and STAT3\n", + "looking for paths in the network with length: 8 for node RPS6KA1 and STAT3\n", + "looking for paths in the network with length: 9 for node RPS6KA1 and STAT3\n", + "looking for paths in the network with length: 10 for node RPS6KA1 and STAT3\n", + "i_search = 4\n", + "Looking for paths with length: 0 for node RPS6KA1 and STAT3\n", + "i_search = 4\n", + "Looking for paths with length: 1 for node RPS6KA1 and STAT3\n", + "i_search = 4\n", + "Looking for paths with length: 2 for node RPS6KA1 and STAT3\n", + "i_search = 4\n", + "Looking for paths with length: 3 for node RPS6KA1 and STAT3\n", + "i_search = 4\n", + "Looking for paths with length: 4 for node RPS6KA1 and STAT3\n", + "looking for paths in the network with length: 0 for node RPS6KA1 and CHEK2\n", + "looking for paths in the network with length: 1 for node RPS6KA1 and CHEK2\n", + "looking for paths in the network with length: 2 for node RPS6KA1 and CHEK2\n", + "looking for paths in the network with length: 3 for node RPS6KA1 and CHEK2\n", + "looking for paths in the network with length: 4 for node RPS6KA1 and CHEK2\n", + "looking for paths in the network with length: 5 for node RPS6KA1 and CHEK2\n", + "looking for paths in the network with length: 6 for node RPS6KA1 and CHEK2\n", + "looking for paths in the network with length: 7 for node RPS6KA1 and CHEK2\n", + "looking for paths in the network with length: 8 for node RPS6KA1 and CHEK2\n", + "looking for paths in the network with length: 9 for node RPS6KA1 and CHEK2\n", + "looking for paths in the network with length: 10 for node RPS6KA1 and CHEK2\n", + "i_search = 4\n", + "Looking for paths with length: 0 for node RPS6KA1 and CHEK2\n", + "i_search = 4\n", + "Looking for paths with length: 1 for node RPS6KA1 and CHEK2\n", + "i_search = 4\n", + "Looking for paths with length: 2 for node RPS6KA1 and CHEK2\n", + "i_search = 4\n", + "Looking for paths with length: 3 for node RPS6KA1 and CHEK2\n", + "i_search = 4\n", + "Looking for paths with length: 4 for node RPS6KA1 and CHEK2\n", + "looking for paths in the network with length: 0 for node RPS6KA1 and RELA\n", + "looking for paths in the network with length: 1 for node RPS6KA1 and RELA\n", + "looking for paths in the network with length: 2 for node RPS6KA1 and RELA\n", + "looking for paths in the network with length: 3 for node RPS6KA1 and RELA\n", + "looking for paths in the network with length: 4 for node RPS6KA1 and RELA\n", + "looking for paths in the network with length: 5 for node RPS6KA1 and RELA\n", + "looking for paths in the network with length: 6 for node RPS6KA1 and RELA\n", + "looking for paths in the network with length: 7 for node RPS6KA1 and RELA\n", + "looking for paths in the network with length: 8 for node RPS6KA1 and RELA\n", + "looking for paths in the network with length: 9 for node RPS6KA1 and RELA\n", + "looking for paths in the network with length: 10 for node RPS6KA1 and RELA\n", + "i_search = 4\n", + "Looking for paths with length: 0 for node RPS6KA1 and RELA\n", + "i_search = 4\n", + "Looking for paths with length: 1 for node RPS6KA1 and RELA\n", + "i_search = 4\n", + "Looking for paths with length: 2 for node RPS6KA1 and RELA\n", + "i_search = 4\n", + "Looking for paths with length: 3 for node RPS6KA1 and RELA\n", + "i_search = 4\n", + "Looking for paths with length: 4 for node RPS6KA1 and RELA\n", + "looking for paths in the network with length: 0 for node RPS6KA1 and MARCKS\n", + "looking for paths in the network with length: 1 for node RPS6KA1 and MARCKS\n", + "looking for paths in the network with length: 2 for node RPS6KA1 and MARCKS\n", + "looking for paths in the network with length: 3 for node RPS6KA1 and MARCKS\n", + "looking for paths in the network with length: 4 for node RPS6KA1 and MARCKS\n", + "looking for paths in the network with length: 5 for node RPS6KA1 and MARCKS\n", + "looking for paths in the network with length: 6 for node RPS6KA1 and MARCKS\n", + "looking for paths in the network with length: 7 for node RPS6KA1 and MARCKS\n", + "looking for paths in the network with length: 8 for node RPS6KA1 and MARCKS\n", + "looking for paths in the network with length: 9 for node RPS6KA1 and MARCKS\n", + "looking for paths in the network with length: 10 for node RPS6KA1 and MARCKS\n", + "i_search = 4\n", + "Looking for paths with length: 0 for node RPS6KA1 and MARCKS\n", + "i_search = 4\n", + "Looking for paths with length: 1 for node RPS6KA1 and MARCKS\n", + "i_search = 4\n", + "Looking for paths with length: 2 for node RPS6KA1 and MARCKS\n", + "i_search = 4\n", + "Looking for paths with length: 3 for node RPS6KA1 and MARCKS\n", + "i_search = 4\n", + "Looking for paths with length: 4 for node RPS6KA1 and MARCKS\n", + "looking for paths in the network with length: 0 for node CREB1 and NFKBIA\n", + "looking for paths in the network with length: 1 for node CREB1 and NFKBIA\n", + "looking for paths in the network with length: 2 for node CREB1 and NFKBIA\n", + "looking for paths in the network with length: 3 for node CREB1 and NFKBIA\n", + "looking for paths in the network with length: 4 for node CREB1 and NFKBIA\n", + "looking for paths in the network with length: 5 for node CREB1 and NFKBIA\n", + "looking for paths in the network with length: 6 for node CREB1 and NFKBIA\n", + "looking for paths in the network with length: 7 for node CREB1 and NFKBIA\n", + "looking for paths in the network with length: 8 for node CREB1 and NFKBIA\n", + "looking for paths in the network with length: 9 for node CREB1 and NFKBIA\n", + "looking for paths in the network with length: 10 for node CREB1 and NFKBIA\n", + "i_search = 4\n", + "Looking for paths with length: 0 for node CREB1 and NFKBIA\n", + "i_search = 4\n", + "Looking for paths with length: 1 for node CREB1 and NFKBIA\n", + "i_search = 4\n", + "Looking for paths with length: 2 for node CREB1 and NFKBIA\n", + "i_search = 4\n", + "Looking for paths with length: 3 for node CREB1 and NFKBIA\n", + "i_search = 4\n", + "Looking for paths with length: 4 for node CREB1 and NFKBIA\n", + "looking for paths in the network with length: 0 for node CREB1 and MTOR\n", + "looking for paths in the network with length: 1 for node CREB1 and MTOR\n", + "looking for paths in the network with length: 2 for node CREB1 and MTOR\n", + "looking for paths in the network with length: 3 for node CREB1 and MTOR\n", + "looking for paths in the network with length: 4 for node CREB1 and MTOR\n", + "looking for paths in the network with length: 5 for node CREB1 and MTOR\n", + "looking for paths in the network with length: 6 for node CREB1 and MTOR\n", + "looking for paths in the network with length: 7 for node CREB1 and MTOR\n", + "looking for paths in the network with length: 8 for node CREB1 and MTOR\n", + "looking for paths in the network with length: 9 for node CREB1 and MTOR\n", + "looking for paths in the network with length: 10 for node CREB1 and MTOR\n", + "i_search = 4\n", + "Looking for paths with length: 0 for node CREB1 and MTOR\n", + "i_search = 4\n", + "Looking for paths with length: 1 for node CREB1 and MTOR\n", + "i_search = 4\n", + "Looking for paths with length: 2 for node CREB1 and MTOR\n", + "i_search = 4\n", + "Looking for paths with length: 3 for node CREB1 and MTOR\n", + "i_search = 4\n", + "Looking for paths with length: 4 for node CREB1 and MTOR\n", + "looking for paths in the network with length: 0 for node CREB1 and JUN\n", + "looking for paths in the network with length: 1 for node CREB1 and JUN\n", + "looking for paths in the network with length: 2 for node CREB1 and JUN\n", + "looking for paths in the network with length: 3 for node CREB1 and JUN\n", + "looking for paths in the network with length: 4 for node CREB1 and JUN\n", + "looking for paths in the network with length: 5 for node CREB1 and JUN\n", + "looking for paths in the network with length: 6 for node CREB1 and JUN\n", + "looking for paths in the network with length: 7 for node CREB1 and JUN\n", + "looking for paths in the network with length: 8 for node CREB1 and JUN\n", + "looking for paths in the network with length: 9 for node CREB1 and JUN\n", + "looking for paths in the network with length: 10 for node CREB1 and JUN\n", + "i_search = 4\n", + "Looking for paths with length: 0 for node CREB1 and JUN\n", + "i_search = 4\n", + "Looking for paths with length: 1 for node CREB1 and JUN\n", + "i_search = 4\n", + "Looking for paths with length: 2 for node CREB1 and JUN\n", + "i_search = 4\n", + "Looking for paths with length: 3 for node CREB1 and JUN\n", + "i_search = 4\n", + "Looking for paths with length: 4 for node CREB1 and JUN\n", + "looking for paths in the network with length: 0 for node CREB1 and EGFR\n", + "looking for paths in the network with length: 1 for node CREB1 and EGFR\n", + "looking for paths in the network with length: 2 for node CREB1 and EGFR\n", + "looking for paths in the network with length: 3 for node CREB1 and EGFR\n", + "looking for paths in the network with length: 4 for node CREB1 and EGFR\n", + "looking for paths in the network with length: 5 for node CREB1 and EGFR\n", + "looking for paths in the network with length: 6 for node CREB1 and EGFR\n", + "looking for paths in the network with length: 7 for node CREB1 and EGFR\n", + "looking for paths in the network with length: 8 for node CREB1 and EGFR\n", + "looking for paths in the network with length: 9 for node CREB1 and EGFR\n", + "looking for paths in the network with length: 10 for node CREB1 and EGFR\n", + "i_search = 4\n", + "Looking for paths with length: 0 for node CREB1 and EGFR\n", + "i_search = 4\n", + "Looking for paths with length: 1 for node CREB1 and EGFR\n", + "i_search = 4\n", + "Looking for paths with length: 2 for node CREB1 and EGFR\n", + "i_search = 4\n", + "Looking for paths with length: 3 for node CREB1 and EGFR\n", + "i_search = 4\n", + "Looking for paths with length: 4 for node CREB1 and EGFR\n", + "looking for paths in the network with length: 0 for node CREB1 and MAPK3\n", + "looking for paths in the network with length: 1 for node CREB1 and MAPK3\n", + "looking for paths in the network with length: 2 for node CREB1 and MAPK3\n", + "looking for paths in the network with length: 3 for node CREB1 and MAPK3\n", + "looking for paths in the network with length: 4 for node CREB1 and MAPK3\n", + "looking for paths in the network with length: 5 for node CREB1 and MAPK3\n", + "looking for paths in the network with length: 6 for node CREB1 and MAPK3\n", + "looking for paths in the network with length: 7 for node CREB1 and MAPK3\n", + "looking for paths in the network with length: 8 for node CREB1 and MAPK3\n", + "looking for paths in the network with length: 9 for node CREB1 and MAPK3\n", + "looking for paths in the network with length: 10 for node CREB1 and MAPK3\n", + "i_search = 4\n", + "Looking for paths with length: 0 for node CREB1 and MAPK3\n", + "i_search = 4\n", + "Looking for paths with length: 1 for node CREB1 and MAPK3\n", + "i_search = 4\n", + "Looking for paths with length: 2 for node CREB1 and MAPK3\n", + "i_search = 4\n", + "Looking for paths with length: 3 for node CREB1 and MAPK3\n", + "i_search = 4\n", + "Looking for paths with length: 4 for node CREB1 and MAPK3\n", + "looking for paths in the network with length: 0 for node CREB1 and PTPN11\n", + "looking for paths in the network with length: 1 for node CREB1 and PTPN11\n", + "looking for paths in the network with length: 2 for node CREB1 and PTPN11\n", + "looking for paths in the network with length: 3 for node CREB1 and PTPN11\n", + "looking for paths in the network with length: 4 for node CREB1 and PTPN11\n", + "looking for paths in the network with length: 5 for node CREB1 and PTPN11\n", + "looking for paths in the network with length: 6 for node CREB1 and PTPN11\n", + "looking for paths in the network with length: 7 for node CREB1 and PTPN11\n", + "looking for paths in the network with length: 8 for node CREB1 and PTPN11\n", + "looking for paths in the network with length: 9 for node CREB1 and PTPN11\n", + "looking for paths in the network with length: 10 for node CREB1 and PTPN11\n", + "i_search = 4\n", + "Looking for paths with length: 0 for node CREB1 and PTPN11\n", + "i_search = 4\n", + "Looking for paths with length: 1 for node CREB1 and PTPN11\n", + "i_search = 4\n", + "Looking for paths with length: 2 for node CREB1 and PTPN11\n", + "i_search = 4\n", + "Looking for paths with length: 3 for node CREB1 and PTPN11\n", + "i_search = 4\n", + "Looking for paths with length: 4 for node CREB1 and PTPN11\n", + "looking for paths in the network with length: 0 for node CREB1 and STAT3\n", + "looking for paths in the network with length: 1 for node CREB1 and STAT3\n", + "looking for paths in the network with length: 2 for node CREB1 and STAT3\n", + "looking for paths in the network with length: 3 for node CREB1 and STAT3\n", + "looking for paths in the network with length: 4 for node CREB1 and STAT3\n", + "looking for paths in the network with length: 5 for node CREB1 and STAT3\n", + "looking for paths in the network with length: 6 for node CREB1 and STAT3\n", + "looking for paths in the network with length: 7 for node CREB1 and STAT3\n", + "looking for paths in the network with length: 8 for node CREB1 and STAT3\n", + "looking for paths in the network with length: 9 for node CREB1 and STAT3\n", + "looking for paths in the network with length: 10 for node CREB1 and STAT3\n", + "i_search = 4\n", + "Looking for paths with length: 0 for node CREB1 and STAT3\n", + "i_search = 4\n", + "Looking for paths with length: 1 for node CREB1 and STAT3\n", + "i_search = 4\n", + "Looking for paths with length: 2 for node CREB1 and STAT3\n", + "i_search = 4\n", + "Looking for paths with length: 3 for node CREB1 and STAT3\n", + "i_search = 4\n", + "Looking for paths with length: 4 for node CREB1 and STAT3\n", + "looking for paths in the network with length: 0 for node CREB1 and CHEK2\n", + "looking for paths in the network with length: 1 for node CREB1 and CHEK2\n", + "looking for paths in the network with length: 2 for node CREB1 and CHEK2\n", + "looking for paths in the network with length: 3 for node CREB1 and CHEK2\n", + "looking for paths in the network with length: 4 for node CREB1 and CHEK2\n", + "looking for paths in the network with length: 5 for node CREB1 and CHEK2\n", + "looking for paths in the network with length: 6 for node CREB1 and CHEK2\n", + "looking for paths in the network with length: 7 for node CREB1 and CHEK2\n", + "looking for paths in the network with length: 8 for node CREB1 and CHEK2\n", + "looking for paths in the network with length: 9 for node CREB1 and CHEK2\n", + "looking for paths in the network with length: 10 for node CREB1 and CHEK2\n", + "i_search = 4\n", + "Looking for paths with length: 0 for node CREB1 and CHEK2\n", + "i_search = 4\n", + "Looking for paths with length: 1 for node CREB1 and CHEK2\n", + "i_search = 4\n", + "Looking for paths with length: 2 for node CREB1 and CHEK2\n", + "i_search = 4\n", + "Looking for paths with length: 3 for node CREB1 and CHEK2\n", + "i_search = 4\n", + "Looking for paths with length: 4 for node CREB1 and CHEK2\n", + "looking for paths in the network with length: 0 for node CREB1 and RELA\n", + "looking for paths in the network with length: 1 for node CREB1 and RELA\n", + "looking for paths in the network with length: 2 for node CREB1 and RELA\n", + "looking for paths in the network with length: 3 for node CREB1 and RELA\n", + "looking for paths in the network with length: 4 for node CREB1 and RELA\n", + "looking for paths in the network with length: 5 for node CREB1 and RELA\n", + "looking for paths in the network with length: 6 for node CREB1 and RELA\n", + "looking for paths in the network with length: 7 for node CREB1 and RELA\n", + "looking for paths in the network with length: 8 for node CREB1 and RELA\n", + "looking for paths in the network with length: 9 for node CREB1 and RELA\n", + "looking for paths in the network with length: 10 for node CREB1 and RELA\n", + "i_search = 4\n", + "Looking for paths with length: 0 for node CREB1 and RELA\n", + "i_search = 4\n", + "Looking for paths with length: 1 for node CREB1 and RELA\n", + "i_search = 4\n", + "Looking for paths with length: 2 for node CREB1 and RELA\n", + "i_search = 4\n", + "Looking for paths with length: 3 for node CREB1 and RELA\n", + "i_search = 4\n", + "Looking for paths with length: 4 for node CREB1 and RELA\n", + "looking for paths in the network with length: 0 for node CREB1 and MARCKS\n", + "looking for paths in the network with length: 1 for node CREB1 and MARCKS\n", + "looking for paths in the network with length: 2 for node CREB1 and MARCKS\n", + "looking for paths in the network with length: 3 for node CREB1 and MARCKS\n", + "looking for paths in the network with length: 4 for node CREB1 and MARCKS\n", + "looking for paths in the network with length: 5 for node CREB1 and MARCKS\n", + "looking for paths in the network with length: 6 for node CREB1 and MARCKS\n", + "looking for paths in the network with length: 7 for node CREB1 and MARCKS\n", + "looking for paths in the network with length: 8 for node CREB1 and MARCKS\n", + "looking for paths in the network with length: 9 for node CREB1 and MARCKS\n", + "looking for paths in the network with length: 10 for node CREB1 and MARCKS\n", + "i_search = 4\n", + "Looking for paths with length: 0 for node CREB1 and MARCKS\n", + "i_search = 4\n", + "Looking for paths with length: 1 for node CREB1 and MARCKS\n", + "i_search = 4\n", + "Looking for paths with length: 2 for node CREB1 and MARCKS\n", + "i_search = 4\n", + "Looking for paths with length: 3 for node CREB1 and MARCKS\n", + "i_search = 4\n", + "Looking for paths with length: 4 for node CREB1 and MARCKS\n", + "looking for paths in the network with length: 0 for node NFKBIA and MTOR\n", + "looking for paths in the network with length: 1 for node NFKBIA and MTOR\n", + "looking for paths in the network with length: 2 for node NFKBIA and MTOR\n", + "looking for paths in the network with length: 3 for node NFKBIA and MTOR\n", + "looking for paths in the network with length: 4 for node NFKBIA and MTOR\n", + "looking for paths in the network with length: 5 for node NFKBIA and MTOR\n", + "looking for paths in the network with length: 6 for node NFKBIA and MTOR\n", + "looking for paths in the network with length: 7 for node NFKBIA and MTOR\n", + "looking for paths in the network with length: 8 for node NFKBIA and MTOR\n", + "looking for paths in the network with length: 9 for node NFKBIA and MTOR\n", + "looking for paths in the network with length: 10 for node NFKBIA and MTOR\n", + "i_search = 4\n", + "Looking for paths with length: 0 for node NFKBIA and MTOR\n", + "i_search = 4\n", + "Looking for paths with length: 1 for node NFKBIA and MTOR\n", + "i_search = 4\n", + "Looking for paths with length: 2 for node NFKBIA and MTOR\n", + "i_search = 4\n", + "Looking for paths with length: 3 for node NFKBIA and MTOR\n", + "i_search = 4\n", + "Looking for paths with length: 4 for node NFKBIA and MTOR\n", + "looking for paths in the network with length: 0 for node NFKBIA and JUN\n", + "looking for paths in the network with length: 1 for node NFKBIA and JUN\n", + "looking for paths in the network with length: 2 for node NFKBIA and JUN\n", + "looking for paths in the network with length: 3 for node NFKBIA and JUN\n", + "looking for paths in the network with length: 4 for node NFKBIA and JUN\n", + "looking for paths in the network with length: 5 for node NFKBIA and JUN\n", + "looking for paths in the network with length: 6 for node NFKBIA and JUN\n", + "looking for paths in the network with length: 7 for node NFKBIA and JUN\n", + "looking for paths in the network with length: 8 for node NFKBIA and JUN\n", + "looking for paths in the network with length: 9 for node NFKBIA and JUN\n", + "looking for paths in the network with length: 10 for node NFKBIA and JUN\n", + "i_search = 4\n", + "Looking for paths with length: 0 for node NFKBIA and JUN\n", + "i_search = 4\n", + "Looking for paths with length: 1 for node NFKBIA and JUN\n", + "i_search = 4\n", + "Looking for paths with length: 2 for node NFKBIA and JUN\n", + "i_search = 4\n", + "Looking for paths with length: 3 for node NFKBIA and JUN\n", + "i_search = 4\n", + "Looking for paths with length: 4 for node NFKBIA and JUN\n", + "looking for paths in the network with length: 0 for node NFKBIA and EGFR\n", + "looking for paths in the network with length: 1 for node NFKBIA and EGFR\n", + "looking for paths in the network with length: 2 for node NFKBIA and EGFR\n", + "looking for paths in the network with length: 3 for node NFKBIA and EGFR\n", + "looking for paths in the network with length: 4 for node NFKBIA and EGFR\n", + "looking for paths in the network with length: 5 for node NFKBIA and EGFR\n", + "looking for paths in the network with length: 6 for node NFKBIA and EGFR\n", + "looking for paths in the network with length: 7 for node NFKBIA and EGFR\n", + "looking for paths in the network with length: 8 for node NFKBIA and EGFR\n", + "looking for paths in the network with length: 9 for node NFKBIA and EGFR\n", + "looking for paths in the network with length: 10 for node NFKBIA and EGFR\n", + "i_search = 4\n", + "Looking for paths with length: 0 for node NFKBIA and EGFR\n", + "i_search = 4\n", + "Looking for paths with length: 1 for node NFKBIA and EGFR\n", + "i_search = 4\n", + "Looking for paths with length: 2 for node NFKBIA and EGFR\n", + "i_search = 4\n", + "Looking for paths with length: 3 for node NFKBIA and EGFR\n", + "i_search = 4\n", + "Looking for paths with length: 4 for node NFKBIA and EGFR\n", + "looking for paths in the network with length: 0 for node NFKBIA and MAPK3\n", + "looking for paths in the network with length: 1 for node NFKBIA and MAPK3\n", + "looking for paths in the network with length: 2 for node NFKBIA and MAPK3\n", + "looking for paths in the network with length: 3 for node NFKBIA and MAPK3\n", + "looking for paths in the network with length: 4 for node NFKBIA and MAPK3\n", + "looking for paths in the network with length: 5 for node NFKBIA and MAPK3\n", + "looking for paths in the network with length: 6 for node NFKBIA and MAPK3\n", + "looking for paths in the network with length: 7 for node NFKBIA and MAPK3\n", + "looking for paths in the network with length: 8 for node NFKBIA and MAPK3\n", + "looking for paths in the network with length: 9 for node NFKBIA and MAPK3\n", + "looking for paths in the network with length: 10 for node NFKBIA and MAPK3\n", + "i_search = 4\n", + "Looking for paths with length: 0 for node NFKBIA and MAPK3\n", + "i_search = 4\n", + "Looking for paths with length: 1 for node NFKBIA and MAPK3\n", + "i_search = 4\n", + "Looking for paths with length: 2 for node NFKBIA and MAPK3\n", + "i_search = 4\n", + "Looking for paths with length: 3 for node NFKBIA and MAPK3\n", + "i_search = 4\n", + "Looking for paths with length: 4 for node NFKBIA and MAPK3\n", + "looking for paths in the network with length: 0 for node NFKBIA and PTPN11\n", + "looking for paths in the network with length: 1 for node NFKBIA and PTPN11\n", + "looking for paths in the network with length: 2 for node NFKBIA and PTPN11\n", + "looking for paths in the network with length: 3 for node NFKBIA and PTPN11\n", + "looking for paths in the network with length: 4 for node NFKBIA and PTPN11\n", + "looking for paths in the network with length: 5 for node NFKBIA and PTPN11\n", + "looking for paths in the network with length: 6 for node NFKBIA and PTPN11\n", + "looking for paths in the network with length: 7 for node NFKBIA and PTPN11\n", + "looking for paths in the network with length: 8 for node NFKBIA and PTPN11\n", + "looking for paths in the network with length: 9 for node NFKBIA and PTPN11\n", + "looking for paths in the network with length: 10 for node NFKBIA and PTPN11\n", + "i_search = 4\n", + "Looking for paths with length: 0 for node NFKBIA and PTPN11\n", + "i_search = 4\n", + "Looking for paths with length: 1 for node NFKBIA and PTPN11\n", + "i_search = 4\n", + "Looking for paths with length: 2 for node NFKBIA and PTPN11\n", + "i_search = 4\n", + "Looking for paths with length: 3 for node NFKBIA and PTPN11\n", + "i_search = 4\n", + "Looking for paths with length: 4 for node NFKBIA and PTPN11\n", + "looking for paths in the network with length: 0 for node NFKBIA and STAT3\n", + "looking for paths in the network with length: 1 for node NFKBIA and STAT3\n", + "looking for paths in the network with length: 2 for node NFKBIA and STAT3\n", + "looking for paths in the network with length: 3 for node NFKBIA and STAT3\n", + "looking for paths in the network with length: 4 for node NFKBIA and STAT3\n", + "looking for paths in the network with length: 5 for node NFKBIA and STAT3\n", + "looking for paths in the network with length: 6 for node NFKBIA and STAT3\n", + "looking for paths in the network with length: 7 for node NFKBIA and STAT3\n", + "looking for paths in the network with length: 8 for node NFKBIA and STAT3\n", + "looking for paths in the network with length: 9 for node NFKBIA and STAT3\n", + "looking for paths in the network with length: 10 for node NFKBIA and STAT3\n", + "i_search = 4\n", + "Looking for paths with length: 0 for node NFKBIA and STAT3\n", + "i_search = 4\n", + "Looking for paths with length: 1 for node NFKBIA and STAT3\n", + "i_search = 4\n", + "Looking for paths with length: 2 for node NFKBIA and STAT3\n", + "i_search = 4\n", + "Looking for paths with length: 3 for node NFKBIA and STAT3\n", + "i_search = 4\n", + "Looking for paths with length: 4 for node NFKBIA and STAT3\n", + "looking for paths in the network with length: 0 for node NFKBIA and CHEK2\n", + "looking for paths in the network with length: 1 for node NFKBIA and CHEK2\n", + "looking for paths in the network with length: 2 for node NFKBIA and CHEK2\n", + "looking for paths in the network with length: 3 for node NFKBIA and CHEK2\n", + "looking for paths in the network with length: 4 for node NFKBIA and CHEK2\n", + "looking for paths in the network with length: 5 for node NFKBIA and CHEK2\n", + "looking for paths in the network with length: 6 for node NFKBIA and CHEK2\n", + "looking for paths in the network with length: 7 for node NFKBIA and CHEK2\n", + "looking for paths in the network with length: 8 for node NFKBIA and CHEK2\n", + "looking for paths in the network with length: 9 for node NFKBIA and CHEK2\n", + "looking for paths in the network with length: 10 for node NFKBIA and CHEK2\n", + "i_search = 4\n", + "Looking for paths with length: 0 for node NFKBIA and CHEK2\n", + "i_search = 4\n", + "Looking for paths with length: 1 for node NFKBIA and CHEK2\n", + "i_search = 4\n", + "Looking for paths with length: 2 for node NFKBIA and CHEK2\n", + "i_search = 4\n", + "Looking for paths with length: 3 for node NFKBIA and CHEK2\n", + "i_search = 4\n", + "Looking for paths with length: 4 for node NFKBIA and CHEK2\n", + "looking for paths in the network with length: 0 for node NFKBIA and RELA\n", + "looking for paths in the network with length: 1 for node NFKBIA and RELA\n", + "looking for paths in the network with length: 2 for node NFKBIA and RELA\n", + "looking for paths in the network with length: 3 for node NFKBIA and RELA\n", + "looking for paths in the network with length: 4 for node NFKBIA and RELA\n", + "looking for paths in the network with length: 5 for node NFKBIA and RELA\n", + "looking for paths in the network with length: 6 for node NFKBIA and RELA\n", + "looking for paths in the network with length: 7 for node NFKBIA and RELA\n", + "looking for paths in the network with length: 8 for node NFKBIA and RELA\n", + "looking for paths in the network with length: 9 for node NFKBIA and RELA\n", + "looking for paths in the network with length: 10 for node NFKBIA and RELA\n", + "i_search = 4\n", + "Looking for paths with length: 0 for node NFKBIA and RELA\n", + "i_search = 4\n", + "Looking for paths with length: 1 for node NFKBIA and RELA\n", + "i_search = 4\n", + "Looking for paths with length: 2 for node NFKBIA and RELA\n", + "i_search = 4\n", + "Looking for paths with length: 3 for node NFKBIA and RELA\n", + "i_search = 4\n", + "Looking for paths with length: 4 for node NFKBIA and RELA\n", + "looking for paths in the network with length: 0 for node NFKBIA and MARCKS\n", + "looking for paths in the network with length: 1 for node NFKBIA and MARCKS\n", + "looking for paths in the network with length: 2 for node NFKBIA and MARCKS\n", + "looking for paths in the network with length: 3 for node NFKBIA and MARCKS\n", + "looking for paths in the network with length: 4 for node NFKBIA and MARCKS\n", + "looking for paths in the network with length: 5 for node NFKBIA and MARCKS\n", + "looking for paths in the network with length: 6 for node NFKBIA and MARCKS\n", + "looking for paths in the network with length: 7 for node NFKBIA and MARCKS\n", + "looking for paths in the network with length: 8 for node NFKBIA and MARCKS\n", + "looking for paths in the network with length: 9 for node NFKBIA and MARCKS\n", + "looking for paths in the network with length: 10 for node NFKBIA and MARCKS\n", + "i_search = 4\n", + "Looking for paths with length: 0 for node NFKBIA and MARCKS\n", + "i_search = 4\n", + "Looking for paths with length: 1 for node NFKBIA and MARCKS\n", + "i_search = 4\n", + "Looking for paths with length: 2 for node NFKBIA and MARCKS\n", + "i_search = 4\n", + "Looking for paths with length: 3 for node NFKBIA and MARCKS\n", + "i_search = 4\n", + "Looking for paths with length: 4 for node NFKBIA and MARCKS\n", + "looking for paths in the network with length: 0 for node MTOR and JUN\n", + "looking for paths in the network with length: 1 for node MTOR and JUN\n", + "looking for paths in the network with length: 2 for node MTOR and JUN\n", + "looking for paths in the network with length: 3 for node MTOR and JUN\n", + "looking for paths in the network with length: 4 for node MTOR and JUN\n", + "looking for paths in the network with length: 5 for node MTOR and JUN\n", + "looking for paths in the network with length: 6 for node MTOR and JUN\n", + "looking for paths in the network with length: 7 for node MTOR and JUN\n", + "looking for paths in the network with length: 8 for node MTOR and JUN\n", + "looking for paths in the network with length: 9 for node MTOR and JUN\n", + "looking for paths in the network with length: 10 for node MTOR and JUN\n", + "i_search = 4\n", + "Looking for paths with length: 0 for node MTOR and JUN\n", + "i_search = 4\n", + "Looking for paths with length: 1 for node MTOR and JUN\n", + "i_search = 4\n", + "Looking for paths with length: 2 for node MTOR and JUN\n", + "i_search = 4\n", + "Looking for paths with length: 3 for node MTOR and JUN\n", + "i_search = 4\n", + "Looking for paths with length: 4 for node MTOR and JUN\n", + "looking for paths in the network with length: 0 for node MTOR and EGFR\n", + "looking for paths in the network with length: 1 for node MTOR and EGFR\n", + "looking for paths in the network with length: 2 for node MTOR and EGFR\n", + "looking for paths in the network with length: 3 for node MTOR and EGFR\n", + "looking for paths in the network with length: 4 for node MTOR and EGFR\n", + "looking for paths in the network with length: 5 for node MTOR and EGFR\n", + "looking for paths in the network with length: 6 for node MTOR and EGFR\n", + "looking for paths in the network with length: 7 for node MTOR and EGFR\n", + "looking for paths in the network with length: 8 for node MTOR and EGFR\n", + "looking for paths in the network with length: 9 for node MTOR and EGFR\n", + "looking for paths in the network with length: 10 for node MTOR and EGFR\n", + "i_search = 4\n", + "Looking for paths with length: 0 for node MTOR and EGFR\n", + "i_search = 4\n", + "Looking for paths with length: 1 for node MTOR and EGFR\n", + "i_search = 4\n", + "Looking for paths with length: 2 for node MTOR and EGFR\n", + "i_search = 4\n", + "Looking for paths with length: 3 for node MTOR and EGFR\n", + "i_search = 4\n", + "Looking for paths with length: 4 for node MTOR and EGFR\n", + "looking for paths in the network with length: 0 for node MTOR and MAPK3\n", + "looking for paths in the network with length: 1 for node MTOR and MAPK3\n", + "looking for paths in the network with length: 2 for node MTOR and MAPK3\n", + "looking for paths in the network with length: 3 for node MTOR and MAPK3\n", + "looking for paths in the network with length: 4 for node MTOR and MAPK3\n", + "looking for paths in the network with length: 5 for node MTOR and MAPK3\n", + "looking for paths in the network with length: 6 for node MTOR and MAPK3\n", + "looking for paths in the network with length: 7 for node MTOR and MAPK3\n", + "looking for paths in the network with length: 8 for node MTOR and MAPK3\n", + "looking for paths in the network with length: 9 for node MTOR and MAPK3\n", + "looking for paths in the network with length: 10 for node MTOR and MAPK3\n", + "i_search = 4\n", + "Looking for paths with length: 0 for node MTOR and MAPK3\n", + "i_search = 4\n", + "Looking for paths with length: 1 for node MTOR and MAPK3\n", + "i_search = 4\n", + "Looking for paths with length: 2 for node MTOR and MAPK3\n", + "i_search = 4\n", + "Looking for paths with length: 3 for node MTOR and MAPK3\n", + "i_search = 4\n", + "Looking for paths with length: 4 for node MTOR and MAPK3\n", + "looking for paths in the network with length: 0 for node MTOR and PTPN11\n", + "looking for paths in the network with length: 1 for node MTOR and PTPN11\n", + "looking for paths in the network with length: 2 for node MTOR and PTPN11\n", + "looking for paths in the network with length: 3 for node MTOR and PTPN11\n", + "looking for paths in the network with length: 4 for node MTOR and PTPN11\n", + "looking for paths in the network with length: 5 for node MTOR and PTPN11\n", + "looking for paths in the network with length: 6 for node MTOR and PTPN11\n", + "looking for paths in the network with length: 7 for node MTOR and PTPN11\n", + "looking for paths in the network with length: 8 for node MTOR and PTPN11\n", + "looking for paths in the network with length: 9 for node MTOR and PTPN11\n", + "looking for paths in the network with length: 10 for node MTOR and PTPN11\n", + "i_search = 4\n", + "Looking for paths with length: 0 for node MTOR and PTPN11\n", + "i_search = 4\n", + "Looking for paths with length: 1 for node MTOR and PTPN11\n", + "i_search = 4\n", + "Looking for paths with length: 2 for node MTOR and PTPN11\n", + "i_search = 4\n", + "Looking for paths with length: 3 for node MTOR and PTPN11\n", + "i_search = 4\n", + "Looking for paths with length: 4 for node MTOR and PTPN11\n", + "looking for paths in the network with length: 0 for node MTOR and STAT3\n", + "looking for paths in the network with length: 1 for node MTOR and STAT3\n", + "looking for paths in the network with length: 2 for node MTOR and STAT3\n", + "looking for paths in the network with length: 3 for node MTOR and STAT3\n", + "looking for paths in the network with length: 4 for node MTOR and STAT3\n", + "looking for paths in the network with length: 5 for node MTOR and STAT3\n", + "looking for paths in the network with length: 6 for node MTOR and STAT3\n", + "looking for paths in the network with length: 7 for node MTOR and STAT3\n", + "looking for paths in the network with length: 8 for node MTOR and STAT3\n", + "looking for paths in the network with length: 9 for node MTOR and STAT3\n", + "looking for paths in the network with length: 10 for node MTOR and STAT3\n", + "i_search = 4\n", + "Looking for paths with length: 0 for node MTOR and STAT3\n", + "i_search = 4\n", + "Looking for paths with length: 1 for node MTOR and STAT3\n", + "i_search = 4\n", + "Looking for paths with length: 2 for node MTOR and STAT3\n", + "i_search = 4\n", + "Looking for paths with length: 3 for node MTOR and STAT3\n", + "i_search = 4\n", + "Looking for paths with length: 4 for node MTOR and STAT3\n", + "looking for paths in the network with length: 0 for node MTOR and CHEK2\n", + "looking for paths in the network with length: 1 for node MTOR and CHEK2\n", + "looking for paths in the network with length: 2 for node MTOR and CHEK2\n", + "looking for paths in the network with length: 3 for node MTOR and CHEK2\n", + "looking for paths in the network with length: 4 for node MTOR and CHEK2\n", + "looking for paths in the network with length: 5 for node MTOR and CHEK2\n", + "looking for paths in the network with length: 6 for node MTOR and CHEK2\n", + "looking for paths in the network with length: 7 for node MTOR and CHEK2\n", + "looking for paths in the network with length: 8 for node MTOR and CHEK2\n", + "looking for paths in the network with length: 9 for node MTOR and CHEK2\n", + "looking for paths in the network with length: 10 for node MTOR and CHEK2\n", + "i_search = 4\n", + "Looking for paths with length: 0 for node MTOR and CHEK2\n", + "i_search = 4\n", + "Looking for paths with length: 1 for node MTOR and CHEK2\n", + "i_search = 4\n", + "Looking for paths with length: 2 for node MTOR and CHEK2\n", + "i_search = 4\n", + "Looking for paths with length: 3 for node MTOR and CHEK2\n", + "i_search = 4\n", + "Looking for paths with length: 4 for node MTOR and CHEK2\n", + "looking for paths in the network with length: 0 for node MTOR and RELA\n", + "looking for paths in the network with length: 1 for node MTOR and RELA\n", + "looking for paths in the network with length: 2 for node MTOR and RELA\n", + "looking for paths in the network with length: 3 for node MTOR and RELA\n", + "looking for paths in the network with length: 4 for node MTOR and RELA\n", + "looking for paths in the network with length: 5 for node MTOR and RELA\n", + "looking for paths in the network with length: 6 for node MTOR and RELA\n", + "looking for paths in the network with length: 7 for node MTOR and RELA\n", + "looking for paths in the network with length: 8 for node MTOR and RELA\n", + "looking for paths in the network with length: 9 for node MTOR and RELA\n", + "looking for paths in the network with length: 10 for node MTOR and RELA\n", + "i_search = 4\n", + "Looking for paths with length: 0 for node MTOR and RELA\n", + "i_search = 4\n", + "Looking for paths with length: 1 for node MTOR and RELA\n", + "i_search = 4\n", + "Looking for paths with length: 2 for node MTOR and RELA\n", + "i_search = 4\n", + "Looking for paths with length: 3 for node MTOR and RELA\n", + "i_search = 4\n", + "Looking for paths with length: 4 for node MTOR and RELA\n", + "looking for paths in the network with length: 0 for node MTOR and MARCKS\n", + "looking for paths in the network with length: 1 for node MTOR and MARCKS\n", + "looking for paths in the network with length: 2 for node MTOR and MARCKS\n", + "looking for paths in the network with length: 3 for node MTOR and MARCKS\n", + "looking for paths in the network with length: 4 for node MTOR and MARCKS\n", + "looking for paths in the network with length: 5 for node MTOR and MARCKS\n", + "looking for paths in the network with length: 6 for node MTOR and MARCKS\n", + "looking for paths in the network with length: 7 for node MTOR and MARCKS\n", + "looking for paths in the network with length: 8 for node MTOR and MARCKS\n", + "looking for paths in the network with length: 9 for node MTOR and MARCKS\n", + "looking for paths in the network with length: 10 for node MTOR and MARCKS\n", + "i_search = 4\n", + "Looking for paths with length: 0 for node MTOR and MARCKS\n", + "i_search = 4\n", + "Looking for paths with length: 1 for node MTOR and MARCKS\n", + "i_search = 4\n", + "Looking for paths with length: 2 for node MTOR and MARCKS\n", + "i_search = 4\n", + "Looking for paths with length: 3 for node MTOR and MARCKS\n", + "i_search = 4\n", + "Looking for paths with length: 4 for node MTOR and MARCKS\n", + "looking for paths in the network with length: 0 for node JUN and EGFR\n", + "looking for paths in the network with length: 1 for node JUN and EGFR\n", + "looking for paths in the network with length: 2 for node JUN and EGFR\n", + "looking for paths in the network with length: 3 for node JUN and EGFR\n", + "looking for paths in the network with length: 4 for node JUN and EGFR\n", + "looking for paths in the network with length: 5 for node JUN and EGFR\n", + "looking for paths in the network with length: 6 for node JUN and EGFR\n", + "looking for paths in the network with length: 7 for node JUN and EGFR\n", + "looking for paths in the network with length: 8 for node JUN and EGFR\n", + "looking for paths in the network with length: 9 for node JUN and EGFR\n", + "looking for paths in the network with length: 10 for node JUN and EGFR\n", + "i_search = 4\n", + "Looking for paths with length: 0 for node JUN and EGFR\n", + "i_search = 4\n", + "Looking for paths with length: 1 for node JUN and EGFR\n", + "i_search = 4\n", + "Looking for paths with length: 2 for node JUN and EGFR\n", + "i_search = 4\n", + "Looking for paths with length: 3 for node JUN and EGFR\n", + "i_search = 4\n", + "Looking for paths with length: 4 for node JUN and EGFR\n", + "looking for paths in the network with length: 0 for node JUN and MAPK3\n", + "looking for paths in the network with length: 1 for node JUN and MAPK3\n", + "looking for paths in the network with length: 2 for node JUN and MAPK3\n", + "looking for paths in the network with length: 3 for node JUN and MAPK3\n", + "looking for paths in the network with length: 4 for node JUN and MAPK3\n", + "looking for paths in the network with length: 5 for node JUN and MAPK3\n", + "looking for paths in the network with length: 6 for node JUN and MAPK3\n", + "looking for paths in the network with length: 7 for node JUN and MAPK3\n", + "looking for paths in the network with length: 8 for node JUN and MAPK3\n", + "looking for paths in the network with length: 9 for node JUN and MAPK3\n", + "looking for paths in the network with length: 10 for node JUN and MAPK3\n", + "i_search = 4\n", + "Looking for paths with length: 0 for node JUN and MAPK3\n", + "i_search = 4\n", + "Looking for paths with length: 1 for node JUN and MAPK3\n", + "i_search = 4\n", + "Looking for paths with length: 2 for node JUN and MAPK3\n", + "i_search = 4\n", + "Looking for paths with length: 3 for node JUN and MAPK3\n", + "i_search = 4\n", + "Looking for paths with length: 4 for node JUN and MAPK3\n", + "looking for paths in the network with length: 0 for node JUN and PTPN11\n", + "looking for paths in the network with length: 1 for node JUN and PTPN11\n", + "looking for paths in the network with length: 2 for node JUN and PTPN11\n", + "looking for paths in the network with length: 3 for node JUN and PTPN11\n", + "looking for paths in the network with length: 4 for node JUN and PTPN11\n", + "looking for paths in the network with length: 5 for node JUN and PTPN11\n", + "looking for paths in the network with length: 6 for node JUN and PTPN11\n", + "looking for paths in the network with length: 7 for node JUN and PTPN11\n", + "looking for paths in the network with length: 8 for node JUN and PTPN11\n", + "looking for paths in the network with length: 9 for node JUN and PTPN11\n", + "looking for paths in the network with length: 10 for node JUN and PTPN11\n", + "i_search = 4\n", + "Looking for paths with length: 0 for node JUN and PTPN11\n", + "i_search = 4\n", + "Looking for paths with length: 1 for node JUN and PTPN11\n", + "i_search = 4\n", + "Looking for paths with length: 2 for node JUN and PTPN11\n", + "i_search = 4\n", + "Looking for paths with length: 3 for node JUN and PTPN11\n", + "i_search = 4\n", + "Looking for paths with length: 4 for node JUN and PTPN11\n", + "looking for paths in the network with length: 0 for node JUN and STAT3\n", + "looking for paths in the network with length: 1 for node JUN and STAT3\n", + "looking for paths in the network with length: 2 for node JUN and STAT3\n", + "looking for paths in the network with length: 3 for node JUN and STAT3\n", + "looking for paths in the network with length: 4 for node JUN and STAT3\n", + "looking for paths in the network with length: 5 for node JUN and STAT3\n", + "looking for paths in the network with length: 6 for node JUN and STAT3\n", + "looking for paths in the network with length: 7 for node JUN and STAT3\n", + "looking for paths in the network with length: 8 for node JUN and STAT3\n", + "looking for paths in the network with length: 9 for node JUN and STAT3\n", + "looking for paths in the network with length: 10 for node JUN and STAT3\n", + "i_search = 4\n", + "Looking for paths with length: 0 for node JUN and STAT3\n", + "i_search = 4\n", + "Looking for paths with length: 1 for node JUN and STAT3\n", + "i_search = 4\n", + "Looking for paths with length: 2 for node JUN and STAT3\n", + "i_search = 4\n", + "Looking for paths with length: 3 for node JUN and STAT3\n", + "i_search = 4\n", + "Looking for paths with length: 4 for node JUN and STAT3\n", + "looking for paths in the network with length: 0 for node JUN and CHEK2\n", + "looking for paths in the network with length: 1 for node JUN and CHEK2\n", + "looking for paths in the network with length: 2 for node JUN and CHEK2\n", + "looking for paths in the network with length: 3 for node JUN and CHEK2\n", + "looking for paths in the network with length: 4 for node JUN and CHEK2\n", + "looking for paths in the network with length: 5 for node JUN and CHEK2\n", + "looking for paths in the network with length: 6 for node JUN and CHEK2\n", + "looking for paths in the network with length: 7 for node JUN and CHEK2\n", + "looking for paths in the network with length: 8 for node JUN and CHEK2\n", + "looking for paths in the network with length: 9 for node JUN and CHEK2\n", + "looking for paths in the network with length: 10 for node JUN and CHEK2\n", + "i_search = 4\n", + "Looking for paths with length: 0 for node JUN and CHEK2\n", + "i_search = 4\n", + "Looking for paths with length: 1 for node JUN and CHEK2\n", + "i_search = 4\n", + "Looking for paths with length: 2 for node JUN and CHEK2\n", + "i_search = 4\n", + "Looking for paths with length: 3 for node JUN and CHEK2\n", + "i_search = 4\n", + "Looking for paths with length: 4 for node JUN and CHEK2\n", + "looking for paths in the network with length: 0 for node JUN and RELA\n", + "looking for paths in the network with length: 1 for node JUN and RELA\n", + "looking for paths in the network with length: 2 for node JUN and RELA\n", + "looking for paths in the network with length: 3 for node JUN and RELA\n", + "looking for paths in the network with length: 4 for node JUN and RELA\n", + "looking for paths in the network with length: 5 for node JUN and RELA\n", + "looking for paths in the network with length: 6 for node JUN and RELA\n", + "looking for paths in the network with length: 7 for node JUN and RELA\n", + "looking for paths in the network with length: 8 for node JUN and RELA\n", + "looking for paths in the network with length: 9 for node JUN and RELA\n", + "looking for paths in the network with length: 10 for node JUN and RELA\n", + "i_search = 4\n", + "Looking for paths with length: 0 for node JUN and RELA\n", + "i_search = 4\n", + "Looking for paths with length: 1 for node JUN and RELA\n", + "i_search = 4\n", + "Looking for paths with length: 2 for node JUN and RELA\n", + "i_search = 4\n", + "Looking for paths with length: 3 for node JUN and RELA\n", + "i_search = 4\n", + "Looking for paths with length: 4 for node JUN and RELA\n", + "looking for paths in the network with length: 0 for node JUN and MARCKS\n", + "looking for paths in the network with length: 1 for node JUN and MARCKS\n", + "looking for paths in the network with length: 2 for node JUN and MARCKS\n", + "looking for paths in the network with length: 3 for node JUN and MARCKS\n", + "looking for paths in the network with length: 4 for node JUN and MARCKS\n", + "looking for paths in the network with length: 5 for node JUN and MARCKS\n", + "looking for paths in the network with length: 6 for node JUN and MARCKS\n", + "looking for paths in the network with length: 7 for node JUN and MARCKS\n", + "looking for paths in the network with length: 8 for node JUN and MARCKS\n", + "looking for paths in the network with length: 9 for node JUN and MARCKS\n", + "looking for paths in the network with length: 10 for node JUN and MARCKS\n", + "i_search = 4\n", + "Looking for paths with length: 0 for node JUN and MARCKS\n", + "i_search = 4\n", + "Looking for paths with length: 1 for node JUN and MARCKS\n", + "i_search = 4\n", + "Looking for paths with length: 2 for node JUN and MARCKS\n", + "i_search = 4\n", + "Looking for paths with length: 3 for node JUN and MARCKS\n", + "i_search = 4\n", + "Looking for paths with length: 4 for node JUN and MARCKS\n", + "looking for paths in the network with length: 0 for node EGFR and MAPK3\n", + "looking for paths in the network with length: 1 for node EGFR and MAPK3\n", + "looking for paths in the network with length: 2 for node EGFR and MAPK3\n", + "looking for paths in the network with length: 3 for node EGFR and MAPK3\n", + "looking for paths in the network with length: 4 for node EGFR and MAPK3\n", + "looking for paths in the network with length: 5 for node EGFR and MAPK3\n", + "looking for paths in the network with length: 6 for node EGFR and MAPK3\n", + "looking for paths in the network with length: 7 for node EGFR and MAPK3\n", + "looking for paths in the network with length: 8 for node EGFR and MAPK3\n", + "looking for paths in the network with length: 9 for node EGFR and MAPK3\n", + "looking for paths in the network with length: 10 for node EGFR and MAPK3\n", + "i_search = 4\n", + "Looking for paths with length: 0 for node EGFR and MAPK3\n", + "i_search = 4\n", + "Looking for paths with length: 1 for node EGFR and MAPK3\n", + "i_search = 4\n", + "Looking for paths with length: 2 for node EGFR and MAPK3\n", + "i_search = 4\n", + "Looking for paths with length: 3 for node EGFR and MAPK3\n", + "i_search = 4\n", + "Looking for paths with length: 4 for node EGFR and MAPK3\n", + "looking for paths in the network with length: 0 for node EGFR and PTPN11\n", + "looking for paths in the network with length: 1 for node EGFR and PTPN11\n", + "looking for paths in the network with length: 2 for node EGFR and PTPN11\n", + "looking for paths in the network with length: 3 for node EGFR and PTPN11\n", + "looking for paths in the network with length: 4 for node EGFR and PTPN11\n", + "looking for paths in the network with length: 5 for node EGFR and PTPN11\n", + "looking for paths in the network with length: 6 for node EGFR and PTPN11\n", + "looking for paths in the network with length: 7 for node EGFR and PTPN11\n", + "looking for paths in the network with length: 8 for node EGFR and PTPN11\n", + "looking for paths in the network with length: 9 for node EGFR and PTPN11\n", + "looking for paths in the network with length: 10 for node EGFR and PTPN11\n", + "i_search = 4\n", + "Looking for paths with length: 0 for node EGFR and PTPN11\n", + "i_search = 4\n", + "Looking for paths with length: 1 for node EGFR and PTPN11\n", + "i_search = 4\n", + "Looking for paths with length: 2 for node EGFR and PTPN11\n", + "i_search = 4\n", + "Looking for paths with length: 3 for node EGFR and PTPN11\n", + "i_search = 4\n", + "Looking for paths with length: 4 for node EGFR and PTPN11\n", + "looking for paths in the network with length: 0 for node EGFR and STAT3\n", + "looking for paths in the network with length: 1 for node EGFR and STAT3\n", + "looking for paths in the network with length: 2 for node EGFR and STAT3\n", + "looking for paths in the network with length: 3 for node EGFR and STAT3\n", + "looking for paths in the network with length: 4 for node EGFR and STAT3\n", + "looking for paths in the network with length: 5 for node EGFR and STAT3\n", + "looking for paths in the network with length: 6 for node EGFR and STAT3\n", + "looking for paths in the network with length: 7 for node EGFR and STAT3\n", + "looking for paths in the network with length: 8 for node EGFR and STAT3\n", + "looking for paths in the network with length: 9 for node EGFR and STAT3\n", + "looking for paths in the network with length: 10 for node EGFR and STAT3\n", + "i_search = 4\n", + "Looking for paths with length: 0 for node EGFR and STAT3\n", + "i_search = 4\n", + "Looking for paths with length: 1 for node EGFR and STAT3\n", + "i_search = 4\n", + "Looking for paths with length: 2 for node EGFR and STAT3\n", + "i_search = 4\n", + "Looking for paths with length: 3 for node EGFR and STAT3\n", + "i_search = 4\n", + "Looking for paths with length: 4 for node EGFR and STAT3\n", + "looking for paths in the network with length: 0 for node EGFR and CHEK2\n", + "looking for paths in the network with length: 1 for node EGFR and CHEK2\n", + "looking for paths in the network with length: 2 for node EGFR and CHEK2\n", + "looking for paths in the network with length: 3 for node EGFR and CHEK2\n", + "looking for paths in the network with length: 4 for node EGFR and CHEK2\n", + "looking for paths in the network with length: 5 for node EGFR and CHEK2\n", + "looking for paths in the network with length: 6 for node EGFR and CHEK2\n", + "looking for paths in the network with length: 7 for node EGFR and CHEK2\n", + "looking for paths in the network with length: 8 for node EGFR and CHEK2\n", + "looking for paths in the network with length: 9 for node EGFR and CHEK2\n", + "looking for paths in the network with length: 10 for node EGFR and CHEK2\n", + "i_search = 4\n", + "Looking for paths with length: 0 for node EGFR and CHEK2\n", + "i_search = 4\n", + "Looking for paths with length: 1 for node EGFR and CHEK2\n", + "i_search = 4\n", + "Looking for paths with length: 2 for node EGFR and CHEK2\n", + "i_search = 4\n", + "Looking for paths with length: 3 for node EGFR and CHEK2\n", + "i_search = 4\n", + "Looking for paths with length: 4 for node EGFR and CHEK2\n", + "looking for paths in the network with length: 0 for node EGFR and RELA\n", + "looking for paths in the network with length: 1 for node EGFR and RELA\n", + "looking for paths in the network with length: 2 for node EGFR and RELA\n", + "looking for paths in the network with length: 3 for node EGFR and RELA\n", + "looking for paths in the network with length: 4 for node EGFR and RELA\n", + "looking for paths in the network with length: 5 for node EGFR and RELA\n", + "looking for paths in the network with length: 6 for node EGFR and RELA\n", + "looking for paths in the network with length: 7 for node EGFR and RELA\n", + "looking for paths in the network with length: 8 for node EGFR and RELA\n", + "looking for paths in the network with length: 9 for node EGFR and RELA\n", + "looking for paths in the network with length: 10 for node EGFR and RELA\n", + "i_search = 4\n", + "Looking for paths with length: 0 for node EGFR and RELA\n", + "i_search = 4\n", + "Looking for paths with length: 1 for node EGFR and RELA\n", + "i_search = 4\n", + "Looking for paths with length: 2 for node EGFR and RELA\n", + "i_search = 4\n", + "Looking for paths with length: 3 for node EGFR and RELA\n", + "i_search = 4\n", + "Looking for paths with length: 4 for node EGFR and RELA\n", + "looking for paths in the network with length: 0 for node EGFR and MARCKS\n", + "looking for paths in the network with length: 1 for node EGFR and MARCKS\n", + "looking for paths in the network with length: 2 for node EGFR and MARCKS\n", + "looking for paths in the network with length: 3 for node EGFR and MARCKS\n", + "looking for paths in the network with length: 4 for node EGFR and MARCKS\n", + "looking for paths in the network with length: 5 for node EGFR and MARCKS\n", + "looking for paths in the network with length: 6 for node EGFR and MARCKS\n", + "looking for paths in the network with length: 7 for node EGFR and MARCKS\n", + "looking for paths in the network with length: 8 for node EGFR and MARCKS\n", + "looking for paths in the network with length: 9 for node EGFR and MARCKS\n", + "looking for paths in the network with length: 10 for node EGFR and MARCKS\n", + "i_search = 4\n", + "Looking for paths with length: 0 for node EGFR and MARCKS\n", + "i_search = 4\n", + "Looking for paths with length: 1 for node EGFR and MARCKS\n", + "i_search = 4\n", + "Looking for paths with length: 2 for node EGFR and MARCKS\n", + "i_search = 4\n", + "Looking for paths with length: 3 for node EGFR and MARCKS\n", + "i_search = 4\n", + "Looking for paths with length: 4 for node EGFR and MARCKS\n", + "looking for paths in the network with length: 0 for node MAPK3 and PTPN11\n", + "looking for paths in the network with length: 1 for node MAPK3 and PTPN11\n", + "looking for paths in the network with length: 2 for node MAPK3 and PTPN11\n", + "looking for paths in the network with length: 3 for node MAPK3 and PTPN11\n", + "looking for paths in the network with length: 4 for node MAPK3 and PTPN11\n", + "looking for paths in the network with length: 5 for node MAPK3 and PTPN11\n", + "looking for paths in the network with length: 6 for node MAPK3 and PTPN11\n", + "looking for paths in the network with length: 7 for node MAPK3 and PTPN11\n", + "looking for paths in the network with length: 8 for node MAPK3 and PTPN11\n", + "looking for paths in the network with length: 9 for node MAPK3 and PTPN11\n", + "looking for paths in the network with length: 10 for node MAPK3 and PTPN11\n", + "i_search = 4\n", + "Looking for paths with length: 0 for node MAPK3 and PTPN11\n", + "i_search = 4\n", + "Looking for paths with length: 1 for node MAPK3 and PTPN11\n", + "i_search = 4\n", + "Looking for paths with length: 2 for node MAPK3 and PTPN11\n", + "i_search = 4\n", + "Looking for paths with length: 3 for node MAPK3 and PTPN11\n", + "i_search = 4\n", + "Looking for paths with length: 4 for node MAPK3 and PTPN11\n", + "looking for paths in the network with length: 0 for node MAPK3 and STAT3\n", + "looking for paths in the network with length: 1 for node MAPK3 and STAT3\n", + "looking for paths in the network with length: 2 for node MAPK3 and STAT3\n", + "looking for paths in the network with length: 3 for node MAPK3 and STAT3\n", + "looking for paths in the network with length: 4 for node MAPK3 and STAT3\n", + "looking for paths in the network with length: 5 for node MAPK3 and STAT3\n", + "looking for paths in the network with length: 6 for node MAPK3 and STAT3\n", + "looking for paths in the network with length: 7 for node MAPK3 and STAT3\n", + "looking for paths in the network with length: 8 for node MAPK3 and STAT3\n", + "looking for paths in the network with length: 9 for node MAPK3 and STAT3\n", + "looking for paths in the network with length: 10 for node MAPK3 and STAT3\n", + "i_search = 4\n", + "Looking for paths with length: 0 for node MAPK3 and STAT3\n", + "i_search = 4\n", + "Looking for paths with length: 1 for node MAPK3 and STAT3\n", + "i_search = 4\n", + "Looking for paths with length: 2 for node MAPK3 and STAT3\n", + "i_search = 4\n", + "Looking for paths with length: 3 for node MAPK3 and STAT3\n", + "i_search = 4\n", + "Looking for paths with length: 4 for node MAPK3 and STAT3\n", + "looking for paths in the network with length: 0 for node MAPK3 and CHEK2\n", + "looking for paths in the network with length: 1 for node MAPK3 and CHEK2\n", + "looking for paths in the network with length: 2 for node MAPK3 and CHEK2\n", + "looking for paths in the network with length: 3 for node MAPK3 and CHEK2\n", + "looking for paths in the network with length: 4 for node MAPK3 and CHEK2\n", + "looking for paths in the network with length: 5 for node MAPK3 and CHEK2\n", + "looking for paths in the network with length: 6 for node MAPK3 and CHEK2\n", + "looking for paths in the network with length: 7 for node MAPK3 and CHEK2\n", + "looking for paths in the network with length: 8 for node MAPK3 and CHEK2\n", + "looking for paths in the network with length: 9 for node MAPK3 and CHEK2\n", + "looking for paths in the network with length: 10 for node MAPK3 and CHEK2\n", + "i_search = 4\n", + "Looking for paths with length: 0 for node MAPK3 and CHEK2\n", + "i_search = 4\n", + "Looking for paths with length: 1 for node MAPK3 and CHEK2\n", + "i_search = 4\n", + "Looking for paths with length: 2 for node MAPK3 and CHEK2\n", + "i_search = 4\n", + "Looking for paths with length: 3 for node MAPK3 and CHEK2\n", + "i_search = 4\n", + "Looking for paths with length: 4 for node MAPK3 and CHEK2\n", + "looking for paths in the network with length: 0 for node MAPK3 and RELA\n", + "looking for paths in the network with length: 1 for node MAPK3 and RELA\n", + "looking for paths in the network with length: 2 for node MAPK3 and RELA\n", + "looking for paths in the network with length: 3 for node MAPK3 and RELA\n", + "looking for paths in the network with length: 4 for node MAPK3 and RELA\n", + "looking for paths in the network with length: 5 for node MAPK3 and RELA\n", + "looking for paths in the network with length: 6 for node MAPK3 and RELA\n", + "looking for paths in the network with length: 7 for node MAPK3 and RELA\n", + "looking for paths in the network with length: 8 for node MAPK3 and RELA\n", + "looking for paths in the network with length: 9 for node MAPK3 and RELA\n", + "looking for paths in the network with length: 10 for node MAPK3 and RELA\n", + "i_search = 4\n", + "Looking for paths with length: 0 for node MAPK3 and RELA\n", + "i_search = 4\n", + "Looking for paths with length: 1 for node MAPK3 and RELA\n", + "i_search = 4\n", + "Looking for paths with length: 2 for node MAPK3 and RELA\n", + "i_search = 4\n", + "Looking for paths with length: 3 for node MAPK3 and RELA\n", + "i_search = 4\n", + "Looking for paths with length: 4 for node MAPK3 and RELA\n", + "looking for paths in the network with length: 0 for node MAPK3 and MARCKS\n", + "looking for paths in the network with length: 1 for node MAPK3 and MARCKS\n", + "looking for paths in the network with length: 2 for node MAPK3 and MARCKS\n", + "looking for paths in the network with length: 3 for node MAPK3 and MARCKS\n", + "looking for paths in the network with length: 4 for node MAPK3 and MARCKS\n", + "looking for paths in the network with length: 5 for node MAPK3 and MARCKS\n", + "looking for paths in the network with length: 6 for node MAPK3 and MARCKS\n", + "looking for paths in the network with length: 7 for node MAPK3 and MARCKS\n", + "looking for paths in the network with length: 8 for node MAPK3 and MARCKS\n", + "looking for paths in the network with length: 9 for node MAPK3 and MARCKS\n", + "looking for paths in the network with length: 10 for node MAPK3 and MARCKS\n", + "i_search = 4\n", + "Looking for paths with length: 0 for node MAPK3 and MARCKS\n", + "i_search = 4\n", + "Looking for paths with length: 1 for node MAPK3 and MARCKS\n", + "i_search = 4\n", + "Looking for paths with length: 2 for node MAPK3 and MARCKS\n", + "i_search = 4\n", + "Looking for paths with length: 3 for node MAPK3 and MARCKS\n", + "i_search = 4\n", + "Looking for paths with length: 4 for node MAPK3 and MARCKS\n", + "looking for paths in the network with length: 0 for node PTPN11 and STAT3\n", + "looking for paths in the network with length: 1 for node PTPN11 and STAT3\n", + "looking for paths in the network with length: 2 for node PTPN11 and STAT3\n", + "looking for paths in the network with length: 3 for node PTPN11 and STAT3\n", + "looking for paths in the network with length: 4 for node PTPN11 and STAT3\n", + "looking for paths in the network with length: 5 for node PTPN11 and STAT3\n", + "looking for paths in the network with length: 6 for node PTPN11 and STAT3\n", + "looking for paths in the network with length: 7 for node PTPN11 and STAT3\n", + "looking for paths in the network with length: 8 for node PTPN11 and STAT3\n", + "looking for paths in the network with length: 9 for node PTPN11 and STAT3\n", + "looking for paths in the network with length: 10 for node PTPN11 and STAT3\n", + "i_search = 4\n", + "Looking for paths with length: 0 for node PTPN11 and STAT3\n", + "i_search = 4\n", + "Looking for paths with length: 1 for node PTPN11 and STAT3\n", + "i_search = 4\n", + "Looking for paths with length: 2 for node PTPN11 and STAT3\n", + "i_search = 4\n", + "Looking for paths with length: 3 for node PTPN11 and STAT3\n", + "i_search = 4\n", + "Looking for paths with length: 4 for node PTPN11 and STAT3\n", + "looking for paths in the network with length: 0 for node PTPN11 and CHEK2\n", + "looking for paths in the network with length: 1 for node PTPN11 and CHEK2\n", + "looking for paths in the network with length: 2 for node PTPN11 and CHEK2\n", + "looking for paths in the network with length: 3 for node PTPN11 and CHEK2\n", + "looking for paths in the network with length: 4 for node PTPN11 and CHEK2\n", + "looking for paths in the network with length: 5 for node PTPN11 and CHEK2\n", + "looking for paths in the network with length: 6 for node PTPN11 and CHEK2\n", + "looking for paths in the network with length: 7 for node PTPN11 and CHEK2\n", + "looking for paths in the network with length: 8 for node PTPN11 and CHEK2\n", + "looking for paths in the network with length: 9 for node PTPN11 and CHEK2\n", + "looking for paths in the network with length: 10 for node PTPN11 and CHEK2\n", + "i_search = 4\n", + "Looking for paths with length: 0 for node PTPN11 and CHEK2\n", + "i_search = 4\n", + "Looking for paths with length: 1 for node PTPN11 and CHEK2\n", + "i_search = 4\n", + "Looking for paths with length: 2 for node PTPN11 and CHEK2\n", + "i_search = 4\n", + "Looking for paths with length: 3 for node PTPN11 and CHEK2\n", + "i_search = 4\n", + "Looking for paths with length: 4 for node PTPN11 and CHEK2\n", + "looking for paths in the network with length: 0 for node PTPN11 and RELA\n", + "looking for paths in the network with length: 1 for node PTPN11 and RELA\n", + "looking for paths in the network with length: 2 for node PTPN11 and RELA\n", + "looking for paths in the network with length: 3 for node PTPN11 and RELA\n", + "looking for paths in the network with length: 4 for node PTPN11 and RELA\n", + "looking for paths in the network with length: 5 for node PTPN11 and RELA\n", + "looking for paths in the network with length: 6 for node PTPN11 and RELA\n", + "looking for paths in the network with length: 7 for node PTPN11 and RELA\n", + "looking for paths in the network with length: 8 for node PTPN11 and RELA\n", + "looking for paths in the network with length: 9 for node PTPN11 and RELA\n", + "looking for paths in the network with length: 10 for node PTPN11 and RELA\n", + "i_search = 4\n", + "Looking for paths with length: 0 for node PTPN11 and RELA\n", + "i_search = 4\n", + "Looking for paths with length: 1 for node PTPN11 and RELA\n", + "i_search = 4\n", + "Looking for paths with length: 2 for node PTPN11 and RELA\n", + "i_search = 4\n", + "Looking for paths with length: 3 for node PTPN11 and RELA\n", + "i_search = 4\n", + "Looking for paths with length: 4 for node PTPN11 and RELA\n", + "looking for paths in the network with length: 0 for node PTPN11 and MARCKS\n", + "looking for paths in the network with length: 1 for node PTPN11 and MARCKS\n", + "looking for paths in the network with length: 2 for node PTPN11 and MARCKS\n", + "looking for paths in the network with length: 3 for node PTPN11 and MARCKS\n", + "looking for paths in the network with length: 4 for node PTPN11 and MARCKS\n", + "looking for paths in the network with length: 5 for node PTPN11 and MARCKS\n", + "looking for paths in the network with length: 6 for node PTPN11 and MARCKS\n", + "looking for paths in the network with length: 7 for node PTPN11 and MARCKS\n", + "looking for paths in the network with length: 8 for node PTPN11 and MARCKS\n", + "looking for paths in the network with length: 9 for node PTPN11 and MARCKS\n", + "looking for paths in the network with length: 10 for node PTPN11 and MARCKS\n", + "i_search = 4\n", + "Looking for paths with length: 0 for node PTPN11 and MARCKS\n", + "i_search = 4\n", + "Looking for paths with length: 1 for node PTPN11 and MARCKS\n", + "i_search = 4\n", + "Looking for paths with length: 2 for node PTPN11 and MARCKS\n", + "i_search = 4\n", + "Looking for paths with length: 3 for node PTPN11 and MARCKS\n", + "i_search = 4\n", + "Looking for paths with length: 4 for node PTPN11 and MARCKS\n", + "looking for paths in the network with length: 0 for node STAT3 and CHEK2\n", + "looking for paths in the network with length: 1 for node STAT3 and CHEK2\n", + "looking for paths in the network with length: 2 for node STAT3 and CHEK2\n", + "looking for paths in the network with length: 3 for node STAT3 and CHEK2\n", + "looking for paths in the network with length: 4 for node STAT3 and CHEK2\n", + "looking for paths in the network with length: 5 for node STAT3 and CHEK2\n", + "looking for paths in the network with length: 6 for node STAT3 and CHEK2\n", + "looking for paths in the network with length: 7 for node STAT3 and CHEK2\n", + "looking for paths in the network with length: 8 for node STAT3 and CHEK2\n", + "looking for paths in the network with length: 9 for node STAT3 and CHEK2\n", + "looking for paths in the network with length: 10 for node STAT3 and CHEK2\n", + "i_search = 4\n", + "Looking for paths with length: 0 for node STAT3 and CHEK2\n", + "i_search = 4\n", + "Looking for paths with length: 1 for node STAT3 and CHEK2\n", + "i_search = 4\n", + "Looking for paths with length: 2 for node STAT3 and CHEK2\n", + "i_search = 4\n", + "Looking for paths with length: 3 for node STAT3 and CHEK2\n", + "i_search = 4\n", + "Looking for paths with length: 4 for node STAT3 and CHEK2\n", + "looking for paths in the network with length: 0 for node STAT3 and RELA\n", + "looking for paths in the network with length: 1 for node STAT3 and RELA\n", + "looking for paths in the network with length: 2 for node STAT3 and RELA\n", + "looking for paths in the network with length: 3 for node STAT3 and RELA\n", + "looking for paths in the network with length: 4 for node STAT3 and RELA\n", + "looking for paths in the network with length: 5 for node STAT3 and RELA\n", + "looking for paths in the network with length: 6 for node STAT3 and RELA\n", + "looking for paths in the network with length: 7 for node STAT3 and RELA\n", + "looking for paths in the network with length: 8 for node STAT3 and RELA\n", + "looking for paths in the network with length: 9 for node STAT3 and RELA\n", + "looking for paths in the network with length: 10 for node STAT3 and RELA\n", + "i_search = 4\n", + "Looking for paths with length: 0 for node STAT3 and RELA\n", + "i_search = 4\n", + "Looking for paths with length: 1 for node STAT3 and RELA\n", + "i_search = 4\n", + "Looking for paths with length: 2 for node STAT3 and RELA\n", + "i_search = 4\n", + "Looking for paths with length: 3 for node STAT3 and RELA\n", + "i_search = 4\n", + "Looking for paths with length: 4 for node STAT3 and RELA\n", + "looking for paths in the network with length: 0 for node STAT3 and MARCKS\n", + "looking for paths in the network with length: 1 for node STAT3 and MARCKS\n", + "looking for paths in the network with length: 2 for node STAT3 and MARCKS\n", + "looking for paths in the network with length: 3 for node STAT3 and MARCKS\n", + "looking for paths in the network with length: 4 for node STAT3 and MARCKS\n", + "looking for paths in the network with length: 5 for node STAT3 and MARCKS\n", + "looking for paths in the network with length: 6 for node STAT3 and MARCKS\n", + "looking for paths in the network with length: 7 for node STAT3 and MARCKS\n", + "looking for paths in the network with length: 8 for node STAT3 and MARCKS\n", + "looking for paths in the network with length: 9 for node STAT3 and MARCKS\n", + "looking for paths in the network with length: 10 for node STAT3 and MARCKS\n", + "i_search = 4\n", + "Looking for paths with length: 0 for node STAT3 and MARCKS\n", + "i_search = 4\n", + "Looking for paths with length: 1 for node STAT3 and MARCKS\n", + "i_search = 4\n", + "Looking for paths with length: 2 for node STAT3 and MARCKS\n", + "i_search = 4\n", + "Looking for paths with length: 3 for node STAT3 and MARCKS\n", + "i_search = 4\n", + "Looking for paths with length: 4 for node STAT3 and MARCKS\n", + "looking for paths in the network with length: 0 for node CHEK2 and RELA\n", + "looking for paths in the network with length: 1 for node CHEK2 and RELA\n", + "looking for paths in the network with length: 2 for node CHEK2 and RELA\n", + "looking for paths in the network with length: 3 for node CHEK2 and RELA\n", + "looking for paths in the network with length: 4 for node CHEK2 and RELA\n", + "looking for paths in the network with length: 5 for node CHEK2 and RELA\n", + "looking for paths in the network with length: 6 for node CHEK2 and RELA\n", + "looking for paths in the network with length: 7 for node CHEK2 and RELA\n", + "looking for paths in the network with length: 8 for node CHEK2 and RELA\n", + "looking for paths in the network with length: 9 for node CHEK2 and RELA\n", + "looking for paths in the network with length: 10 for node CHEK2 and RELA\n", + "i_search = 4\n", + "Looking for paths with length: 0 for node CHEK2 and RELA\n", + "i_search = 4\n", + "Looking for paths with length: 1 for node CHEK2 and RELA\n", + "i_search = 4\n", + "Looking for paths with length: 2 for node CHEK2 and RELA\n", + "i_search = 4\n", + "Looking for paths with length: 3 for node CHEK2 and RELA\n", + "i_search = 4\n", + "Looking for paths with length: 4 for node CHEK2 and RELA\n", + "looking for paths in the network with length: 0 for node CHEK2 and MARCKS\n", + "looking for paths in the network with length: 1 for node CHEK2 and MARCKS\n", + "looking for paths in the network with length: 2 for node CHEK2 and MARCKS\n", + "looking for paths in the network with length: 3 for node CHEK2 and MARCKS\n", + "looking for paths in the network with length: 4 for node CHEK2 and MARCKS\n", + "looking for paths in the network with length: 5 for node CHEK2 and MARCKS\n", + "looking for paths in the network with length: 6 for node CHEK2 and MARCKS\n", + "looking for paths in the network with length: 7 for node CHEK2 and MARCKS\n", + "looking for paths in the network with length: 8 for node CHEK2 and MARCKS\n", + "looking for paths in the network with length: 9 for node CHEK2 and MARCKS\n", + "looking for paths in the network with length: 10 for node CHEK2 and MARCKS\n", + "i_search = 4\n", + "Looking for paths with length: 0 for node CHEK2 and MARCKS\n", + "i_search = 4\n", + "Looking for paths with length: 1 for node CHEK2 and MARCKS\n", + "i_search = 4\n", + "Looking for paths with length: 2 for node CHEK2 and MARCKS\n", + "i_search = 4\n", + "Looking for paths with length: 3 for node CHEK2 and MARCKS\n", + "i_search = 4\n", + "Looking for paths with length: 4 for node CHEK2 and MARCKS\n", + "looking for paths in the network with length: 0 for node RELA and MARCKS\n", + "looking for paths in the network with length: 1 for node RELA and MARCKS\n", + "looking for paths in the network with length: 2 for node RELA and MARCKS\n", + "looking for paths in the network with length: 3 for node RELA and MARCKS\n", + "looking for paths in the network with length: 4 for node RELA and MARCKS\n", + "looking for paths in the network with length: 5 for node RELA and MARCKS\n", + "looking for paths in the network with length: 6 for node RELA and MARCKS\n", + "looking for paths in the network with length: 7 for node RELA and MARCKS\n", + "looking for paths in the network with length: 8 for node RELA and MARCKS\n", + "looking for paths in the network with length: 9 for node RELA and MARCKS\n", + "looking for paths in the network with length: 10 for node RELA and MARCKS\n", + "i_search = 4\n", + "Looking for paths with length: 0 for node RELA and MARCKS\n", + "i_search = 4\n", + "Looking for paths with length: 1 for node RELA and MARCKS\n", + "i_search = 4\n", + "Looking for paths with length: 2 for node RELA and MARCKS\n", + "i_search = 4\n", + "Looking for paths with length: 3 for node RELA and MARCKS\n", + "i_search = 4\n", + "Looking for paths with length: 4 for node RELA and MARCKS\n", + "CPU times: user 14min 59s, sys: 2.52 s, total: 15min 1s\n", + "Wall time: 14min 59s\n" + ] + } + ], + "source": [ + "%%time\n", + "new_net1.complete_connection(mode=\"ALL\", maxlen=10, k_mean=\"extensive\", only_signed=True, connect_node_when_first_introduced=True)" + ] + }, + { + "cell_type": "code", + "execution_count": 21, + "id": "152b9434", + "metadata": {}, + "outputs": [ + { + "data": { + "image/svg+xml": [ + "\n", + "\n", + "\n", + "\n", + "\n", + "\n", + "%3\n", + "\n", + "\n", + "\n", + "NUAK1\n", + "\n", + "NUAK1\n", + "\n", + "\n", + "\n", + "TP53_S15\n", + "\n", + "TP53_S15\n", + "\n", + "\n", + "\n", + "NUAK1->TP53_S15\n", + "\n", + "\n", + "\n", + "\n", + "\n", + "NUAK1_S600\n", + "\n", + "NUAK1_S600\n", + "\n", + "\n", + "\n", + "NUAK1_S600->NUAK1\n", + "\n", + "\n", + "\n", + "\n", + "\n", + "AKT1\n", + "\n", + "AKT1\n", + "\n", + "\n", + "\n", + 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"MAPK3->TP53_S15\n", + "\n", + "\n", + "\n", + "\n", + "\n", + "MAPK3->MAPK3_T207\n", + "\n", + "\n", + "\n", + "\n", + "\n", + "\n", + "MAPK3->MAPK3_Y204\n", + "\n", + "\n", + "\n", + "\n", + "\n", + "RPS6KA1_S380\n", + "\n", + "RPS6KA1_S380\n", + "\n", + "\n", + "\n", + "MAPK3->RPS6KA1_S380\n", + "\n", + "\n", + "\n", + "\n", + "\n", + "MAPK3->GSK3B_T43\n", + "\n", + "\n", + "\n", + "\n", + "\n", + "MAPK3->JUN_S63\n", + "\n", + "\n", + "\n", + "\n", + "\n", + "MAPK3_T207->MAPK3\n", + "\n", + "\n", + "\n", + "\n", + "\n", + "\n", + "MAPK3_T202->MAPK3\n", + "\n", + "\n", + "\n", + "\n", + "\n", + "MAPK3_Y204->MAPK3\n", + "\n", + "\n", + "\n", + "\n", + "\n", + "MAP2K1_S222\n", + "\n", + "MAP2K1_S222\n", + "\n", + "\n", + "\n", + "MAP2K1_S222->MAP2K1\n", + "\n", + "\n", + "\n", + "\n", + "\n", + "RPS6KA1\n", + "\n", + "RPS6KA1\n", + "\n", + "\n", + "\n", + "RPS6KA1->CHEK1_S280\n", + "\n", + "\n", + "\n", + "\n", + "\n", + "RPS6KA1->RPS6KA1_S380\n", + "\n", + "\n", + "\n", + "\n", + "\n", + "RPS6KA1->GSK3B_S9\n", + "\n", + "\n", + "\n", + "\n", + "\n", + "\n", + "NFKBIA_S32\n", + "\n", + "NFKBIA_S32\n", + "\n", + "\n", + "\n", + "RPS6KA1->NFKBIA_S32\n", + "\n", + "\n", + "\n", + "\n", + "\n", + "RPS6KA1_S380->RPS6KA1\n", + "\n", + "\n", + "\n", + "\n", + "\n", + "CHEK2\n", + "\n", + "CHEK2\n", + "\n", + "\n", + "\n", + "CHEK2->TP53_S15\n", + "\n", + "\n", + "\n", + "\n", + "\n", + "CHEK2_T68\n", + "\n", + "CHEK2_T68\n", + "\n", + "\n", + "\n", + "CHEK2->CHEK2_T68\n", + "\n", + "\n", + "\n", + "\n", + "\n", + "AURKB_S331\n", + "\n", + "AURKB_S331\n", + "\n", + "\n", + "\n", + "CHEK2->AURKB_S331\n", + "\n", + "\n", + "\n", + "\n", + "\n", + "MTOR\n", + "\n", + "MTOR\n", + "\n", + "\n", + "\n", + "MTOR->AKT1_S473\n", + "\n", + "\n", + "\n", + "\n", + "\n", + "MTOR->MTOR_S2448\n", + "\n", + "\n", + "\n", + "\n", + "\n", + "AKT1_T450\n", + "\n", + "AKT1_T450\n", + "\n", + "\n", + "\n", + "MTOR->AKT1_T450\n", + "\n", + "\n", + "\n", + "\n", + "\n", + "RPS6KB1_T412\n", + "\n", + "RPS6KB1_T412\n", + "\n", + "\n", + "\n", + "MTOR->RPS6KB1_T412\n", + "\n", + "\n", + "\n", + "\n", + "\n", + "RPS6KB1_S434\n", + "\n", + "RPS6KB1_S434\n", + "\n", + "\n", + "\n", + "MTOR->RPS6KB1_S434\n", + "\n", + "\n", + "\n", + "\n", + "\n", + "RPS6KB1_T389\n", + "\n", + "RPS6KB1_T389\n", + "\n", + "\n", + "\n", + "MTOR->RPS6KB1_T389\n", + "\n", + "\n", + "\n", + "\n", + "\n", + "RPS6KB1_S394\n", + "\n", + "RPS6KB1_S394\n", + "\n", + "\n", + "\n", + "MTOR->RPS6KB1_S394\n", + "\n", + "\n", + "\n", + "\n", + "\n", + "EEF2K_S74\n", + "\n", + "EEF2K_S74\n", + "\n", + "\n", + "\n", + "MTOR->EEF2K_S74\n", + "\n", + "\n", + "\n", + "\n", + "\n", + "\n", + "EEF2K_S72\n", + "\n", + "EEF2K_S72\n", + "\n", + "\n", + "\n", + "MTOR->EEF2K_S72\n", + "\n", + "\n", + "\n", + "\n", + "\n", + "\n", + "SGK1_S422\n", + "\n", + "SGK1_S422\n", + "\n", + "\n", + "\n", + "MTOR->SGK1_S422\n", + "\n", + "\n", + "\n", + "\n", + "\n", + "PRKCB_T642\n", + "\n", + "PRKCB_T642\n", + "\n", + "\n", + "\n", + "MTOR->PRKCB_T642\n", + "\n", + "\n", + "\n", + "\n", + "\n", + "MTOR_S2448->MTOR\n", + "\n", + "\n", + "\n", + "\n", + "\n", + "AKT1_T450->AKT1\n", + "\n", + "\n", + "\n", + "\n", + "\n", + "GSK3B\n", + "\n", + "GSK3B\n", + "\n", + "\n", + "\n", + "GSK3B_S9->GSK3B\n", + "\n", + "\n", + "\n", + "\n", + "\n", + "\n", + "GSK3B->GSK3B_Y216\n", + "\n", + "\n", + "\n", + "\n", + "\n", + "SRC_S493\n", + "\n", + "SRC_S493\n", + "\n", + "\n", + "\n", + "GSK3B->SRC_S493\n", + "\n", + "\n", + "\n", + "\n", + "\n", + "\n", + "SRC_S51\n", + "\n", + "SRC_S51\n", + "\n", + "\n", + "\n", + "GSK3B->SRC_S51\n", + "\n", + "\n", + "\n", + "\n", + "\n", + "SRC_Y419\n", + "\n", + "SRC_Y419\n", + "\n", + "\n", + "\n", + "GSK3B->SRC_Y419\n", + "\n", + "\n", + "\n", + "\n", + "\n", + "SRC_S43\n", + "\n", + "SRC_S43\n", + "\n", + "\n", + "\n", + "GSK3B->SRC_S43\n", + "\n", + "\n", + "\n", + "\n", + "\n", + "TBK1_S172\n", + "\n", + "TBK1_S172\n", + "\n", + "\n", + "\n", + "GSK3B->TBK1_S172\n", + "\n", + "\n", + "\n", + "\n", + "\n", + "GSK3B_T390->GSK3B\n", + "\n", + "\n", + "\n", + "\n", + "\n", + "GSK3B_T43->GSK3B\n", + "\n", + "\n", + "\n", + "\n", + "\n", + "RPS6KB1\n", + "\n", + "RPS6KB1\n", + "\n", + "\n", + "\n", + "RPS6KB1->GSK3B_S9\n", + "\n", + "\n", + "\n", + "\n", + "\n", + "\n", + "RPS6KB1->RPS6KB1_T412\n", + "\n", + "\n", + "\n", + "\n", + "\n", + "RPS6KB1_S434->RPS6KB1\n", + "\n", + "\n", + "\n", + "\n", + "\n", + "RPS6KB1_T389->RPS6KB1\n", + "\n", + "\n", + "\n", + "\n", + "\n", + "RPS6KB1_S394->RPS6KB1\n", + "\n", + "\n", + "\n", + "\n", + "\n", + "EEF2K\n", + "\n", + "EEF2K\n", + "\n", + "\n", + "\n", + "EEF2K->GSK3B_S9\n", + "\n", + "\n", + "\n", + "\n", + "\n", + "\n", + "STAT3_Y705\n", + "\n", + "STAT3_Y705\n", + "\n", + "\n", + "\n", + "EEF2K->STAT3_Y705\n", + "\n", + "\n", + "\n", + "\n", + "\n", + "EEF2K_S74->EEF2K\n", + "\n", + "\n", + "\n", + "\n", + "\n", + "\n", + "EEF2K_S72->EEF2K\n", + "\n", + "\n", + "\n", + "\n", + "\n", + "\n", + "SGK1\n", + "\n", + "SGK1\n", + "\n", + "\n", + "\n", + "SGK1->GSK3B_S9\n", + "\n", + "\n", + "\n", + "\n", + "\n", + "\n", + "SGK1->SGK1_S422\n", + "\n", + "\n", + "\n", + "\n", + "\n", + "SGK1->NFKBIA_S32\n", + "\n", + "\n", + "\n", + "\n", + "\n", + "PRKCB\n", + "\n", + "PRKCB\n", + "\n", + "\n", + "\n", + "PRKCB->GSK3B_S9\n", + "\n", + "\n", + "\n", + "\n", + "\n", + "\n", + "PRKCB_T642->PRKCB\n", + "\n", + "\n", + "\n", + "\n", + "\n", + "SRC\n", + "\n", + "SRC\n", + "\n", + "\n", + "\n", + "SRC_S493->SRC\n", + "\n", + "\n", + "\n", + "\n", + "\n", + "\n", + "SRC->STAT3_Y705\n", + "\n", + "\n", + "\n", + "\n", + "\n", + "SRC_S51->SRC\n", + "\n", + "\n", + "\n", + "\n", + "\n", + "SRC_Y419->SRC\n", + "\n", + "\n", + "\n", + "\n", + "\n", + "SRC_S43->SRC\n", + "\n", + "\n", + "\n", + "\n", + "\n", + "TBK1\n", + "\n", + "TBK1\n", + "\n", + "\n", + "\n", + "TBK1_S172->TBK1\n", + "\n", + "\n", + "\n", + "\n", + "\n", + "RELA_S536\n", + "\n", + "RELA_S536\n", + "\n", + "\n", + "\n", + "TBK1->RELA_S536\n", + "\n", + "\n", + "\n", + "\n", + "\n", + "MAP2K4\n", + "\n", + "MAP2K4\n", + "\n", + "\n", + "\n", + "MAP2K4_S80->MAP2K4\n", + "\n", + "\n", + "\n", + "\n", + "\n", + "\n", + "MAP2K4->MAPK14_T180\n", + "\n", + "\n", + "\n", + "\n", + "\n", + "MAP3K5\n", + "\n", + "MAP3K5\n", + "\n", + "\n", + "\n", + "MAP3K5_S83->MAP3K5\n", + "\n", + "\n", + "\n", + "\n", + "\n", + "MAP3K5->MAPK14_T180\n", + "\n", + "\n", + "\n", + "\n", + "\n", + "MAPKAPK2\n", + "\n", + "MAPKAPK2\n", + "\n", + "\n", + "\n", + "MAPKAPK2->AKT1_S473\n", + "\n", + "\n", + "\n", + "\n", + "\n", + "MAPKAPK2->RPS6KA1_S380\n", + "\n", + "\n", + "\n", + "\n", + "\n", + "HSPB1_S78\n", + "\n", + "HSPB1_S78\n", + "\n", + "\n", + "\n", + "MAPKAPK2->HSPB1_S78\n", + "\n", + "\n", + "\n", + "\n", + "\n", + "MAPKAPK2_T334->MAPKAPK2\n", + "\n", + "\n", + "\n", + "\n", + "\n", + "MAPKAPK2_S272->MAPKAPK2\n", + "\n", + "\n", + "\n", + "\n", + "\n", + "MAPKAPK2_T222->MAPKAPK2\n", + "\n", + "\n", + "\n", + "\n", + "\n", + "RAF1\n", + "\n", + "RAF1\n", + "\n", + "\n", + "\n", + "RAF1_S259->RAF1\n", + "\n", + "\n", + "\n", + "\n", + "\n", + "\n", + "RAF1->MAP2K1_S218\n", + "\n", + "\n", + "\n", + "\n", + "\n", + "RAF1->MAP2K1_S222\n", + "\n", + "\n", + "\n", + "\n", + "\n", + "RAF1->RAF1_S338\n", + "\n", + "\n", + "\n", + "\n", + "\n", + "BRAF\n", + "\n", + "BRAF\n", + "\n", + "\n", + "\n", + "BRAF_S365->BRAF\n", + "\n", + "\n", + "\n", + "\n", + "\n", + "\n", + "BRAF->MAP2K1_S218\n", + "\n", + "\n", + "\n", + "\n", + "\n", + "BRAF->MAP2K1_S222\n", + "\n", + "\n", + "\n", + "\n", + "\n", + "BRAF_S429->BRAF\n", + "\n", + "\n", + "\n", + "\n", + "\n", + "\n", + "CHUK\n", + "\n", + "CHUK\n", + "\n", + "\n", + "\n", + "CHUK_T23->CHUK\n", + "\n", + "\n", + "\n", + "\n", + "\n", + "CHUK->NFKBIA_S32\n", + "\n", + "\n", + "\n", + "\n", + "\n", + "NFKBIA_S36\n", + "\n", + "NFKBIA_S36\n", + "\n", + "\n", + "\n", + "CHUK->NFKBIA_S36\n", + "\n", + "\n", + "\n", + "\n", + "\n", + "RPS6KA3\n", + "\n", + "RPS6KA3\n", + "\n", + "\n", + "\n", + "RPS6KA3_S19->RPS6KA3\n", + "\n", + "\n", + "\n", + "\n", + "\n", + "\n", + "RPS6KA3->NFKBIA_S32\n", + "\n", + "\n", + "\n", + "\n", + "\n", + "RAF1_S338->RAF1\n", + "\n", + "\n", + "\n", + "\n", + "\n", + "AURKB\n", + "\n", + "AURKB\n", + "\n", + "\n", + "\n", + "AURKB->NFKBIA_S32\n", + "\n", + "\n", + "\n", + "\n", + "\n", + "AURKB_S331->AURKB\n", + "\n", + "\n", + "\n", + "\n", + "\n", + "SMAD3_S423\n", + "\n", + "SMAD3_S423\n", + "\n", + "\n", + "\n", + "SMAD3_S425\n", + "\n", + "SMAD3_S425\n", + "\n", + "\n", + "\n", + "GSK3B_S21\n", + "\n", + "GSK3B_S21\n", + "\n", + "\n", + "\n", + "CREB1_S133\n", + "\n", + "CREB1_S133\n", + "\n", + "\n", + "\n", + "EGFR_Y1068\n", + "\n", + "EGFR_Y1068\n", + "\n", + "\n", + "\n", + "PTPN11_Y542\n", + "\n", + "PTPN11_Y542\n", + "\n", + "\n", + "\n", + "MARCKS_S170\n", + "\n", + "MARCKS_S170\n", + "\n", + "\n", + "\n", + "SMAD3\n", + "\n", + "SMAD3\n", + "\n", + "\n", + "\n", + "TP53\n", + "\n", + "TP53\n", + "\n", + "\n", + "\n", + "AKT1S1\n", + "\n", + "AKT1S1\n", + "\n", + "\n", + "\n", + "HSPB1\n", + "\n", + "HSPB1\n", + "\n", + "\n", + "\n", + "CREB1\n", + "\n", + "CREB1\n", + "\n", + "\n", + "\n", + "NFKBIA\n", + "\n", + "NFKBIA\n", + "\n", + "\n", + "\n", + "JUN\n", + "\n", + "JUN\n", + "\n", + "\n", + "\n", + "EGFR\n", + "\n", + "EGFR\n", + "\n", + "\n", + "\n", + "PTPN11\n", + "\n", + "PTPN11\n", + "\n", + "\n", + "\n", + "STAT3\n", + "\n", + "STAT3\n", + "\n", + "\n", + "\n", + "RELA\n", + "\n", + "RELA\n", + "\n", + "\n", + "\n", + "MARCKS\n", + "\n", + "MARCKS\n", + "\n", + "\n", + "\n" + ], + "text/plain": [ + "" + ] + }, + "metadata": {}, + "output_type": "display_data" + } + ], + "source": [ + "visualizer1 = NetworkVisualizer(new_net1, color_by='effect')\n", + "visualizer1.render()" + ] + } + ], + "metadata": { + "kernelspec": { + "display_name": "Python 3 (ipykernel)", + "language": "python", + "name": "python3" + }, + "language_info": { + "codemirror_mode": { + "name": "ipython", + "version": 3 + }, + "file_extension": ".py", + "mimetype": "text/x-python", + "name": "python", + "nbconvert_exporter": "python", + "pygments_lexer": "ipython3", + "version": "3.10.13" + } + }, + "nbformat": 4, + "nbformat_minor": 5 +} From 2348a0a35474641508440d0715a5fc75424efd1c Mon Sep 17 00:00:00 2001 From: Eirinits Date: Thu, 4 Apr 2024 11:51:41 +0200 Subject: [PATCH 07/10] Tutorial: Build network with default settings --- notebooks/network_building.ipynb | 9918 ++++++++++++++++++++++++++++++ 1 file changed, 9918 insertions(+) create mode 100644 notebooks/network_building.ipynb diff --git a/notebooks/network_building.ipynb b/notebooks/network_building.ipynb new file mode 100644 index 0000000..3d4f46d --- /dev/null +++ b/notebooks/network_building.ipynb @@ -0,0 +1,9918 @@ +{ + "cells": [ + { + "cell_type": "markdown", + "id": "55b5595c-fec9-41c3-b756-b95cd0c52048", + "metadata": {}, + "source": [ + "## Network building\n", + "\n", + "This notebook provides the steps to build a network starting from a list of genes, and using the default functionalities of Omniflow." + ] + }, + { + "cell_type": "code", + "execution_count": 2, + "id": "3c317de8", + "metadata": {}, + "outputs": [ + { + "name": "stderr", + "output_type": "stream", + "text": [ + "/home/eirini/anaconda3/envs/omniflow_env/lib/python3.10/site-packages/tqdm/auto.py:21: TqdmWarning: IProgress not found. Please update jupyter and ipywidgets. See https://ipywidgets.readthedocs.io/en/stable/user_install.html\n", + " from .autonotebook import tqdm as notebook_tqdm\n" + ] + }, + { + "ename": "ModuleNotFoundError", + "evalue": "No module named 'omniflow_project._annotations'", + "output_type": "error", + "traceback": [ + "\u001b[0;31m---------------------------------------------------------------------------\u001b[0m", + "\u001b[0;31mModuleNotFoundError\u001b[0m Traceback (most recent call last)", + "File \u001b[0;32m:4\u001b[0m\n", + "\u001b[0;31mModuleNotFoundError\u001b[0m: No module named 'omniflow_project._annotations'" + ] + } + ], + "source": [ + "%%time\n", + "from omniflow_project.core.network import Network\n", + "from omniflow_project._visual.visualize_network import NetworkVisualizer\n", + "from omniflow_project._inputs.resources import Resources\n", + "from omniflow_project._annotations.gene_ontology import Ontology\n", + "import omnipath as op" + ] + }, + { + "cell_type": "markdown", + "id": "7fe1b7d5", + "metadata": {}, + "source": [ + "### 1. Define the list of genes of interest" + ] + }, + { + "cell_type": "code", + "execution_count": 3, + "id": "79c09e13", + "metadata": {}, + "outputs": [], + "source": [ + "genes = [\"SRC\", \"NOTCH1\", \"FAK\", \"CDH1\", \"CDH2\", \"VIM\", \"MAP4K4\", \"LATS1\", \"LATS2\", \"PTK2B\"]" + ] + }, + { + "cell_type": "markdown", + "id": "6a5b5adf", + "metadata": {}, + "source": [ + "### 2. Create a network using as input the gene set. \n", + "\n", + "NB! If no resource is specified, the default used resource by the package is omnipath.all_interactions()" + ] + }, + { + "cell_type": "markdown", + "id": "2910c871-fdfc-4d20-b76f-af213f06a3f0", + "metadata": {}, + "source": [ + "#### 2A. Import genes as network nodes" + ] + }, + { + "cell_type": "code", + "execution_count": 3, + "id": "fcf68a99-8454-41e3-8816-c3f976d04c0b", + "metadata": {}, + "outputs": [ + { + "name": "stdout", + "output_type": "stream", + "text": [ + "Loading deafault omnipath all interactions\n" + ] + } + ], + "source": [ + "new_net1 = Network(genes)" + ] + }, + { + "cell_type": "code", + "execution_count": 4, + "id": "fad00bec-ba72-4943-bf1e-9c60f58f17a2", + "metadata": {}, + "outputs": [ + { + "ename": "NameError", + "evalue": "name 'new_net1' is not defined", + "output_type": "error", + "traceback": [ + "\u001b[0;31m---------------------------------------------------------------------------\u001b[0m", + "\u001b[0;31mNameError\u001b[0m Traceback (most recent call last)", + "Cell \u001b[0;32mIn[4], line 2\u001b[0m\n\u001b[1;32m 1\u001b[0m \u001b[38;5;66;03m#Print node dataframe\u001b[39;00m\n\u001b[0;32m----> 2\u001b[0m \u001b[43mnew_net1\u001b[49m\u001b[38;5;241m.\u001b[39mnodes\n", + "\u001b[0;31mNameError\u001b[0m: name 'new_net1' is not defined" + ] + } + ], + "source": [ + "#Print node dataframe\n", + "new_net1.nodes" + ] + }, + { + "cell_type": "markdown", + "id": "a2759581", + "metadata": {}, + "source": [ + "#### 2B. Explore if the nodes are connected without introducing new intermidiate nodes" + ] + }, + { + "cell_type": "code", + "execution_count": 5, + "id": "a339705b", + "metadata": {}, + "outputs": [ + { + "name": "stdout", + "output_type": "stream", + "text": [ + "P12931 Q05397\n", + "P12931 P19022\n", + "P12931 Q14289\n", + "Q14289 Q05397\n", + "CPU times: user 496 ms, sys: 0 ns, total: 496 ms\n", + "Wall time: 495 ms\n" + ] + } + ], + "source": [ + "%%time\n", + "new_net1.connect_nodes(only_signed=True, consensus_only=True)" + ] + }, + { + "cell_type": "markdown", + "id": "2fb5674d", + "metadata": {}, + "source": [ + "#### 2C. Visualize the network with the following command. \n", + "\n", + "The network picture is also exported in the working repository, in pdf format." + ] + }, + { + "cell_type": "code", + "execution_count": 7, + "id": "db39112a", + "metadata": {}, + "outputs": [ + { + "data": { + "image/svg+xml": [ + "\n", + "\n", + "\n", + "\n", + "\n", + "\n", + "%3\n", + "\n", + "\n", + "\n", + "SRC\n", + "\n", + "SRC\n", + "\n", + "\n", + "\n", + "PTK2\n", + "\n", + "PTK2\n", + "\n", + "\n", + "\n", + "SRC->PTK2\n", + "\n", + "\n", + "\n", + "\n", + "\n", + "CDH2\n", + "\n", + "CDH2\n", + "\n", + "\n", + "\n", + "SRC->CDH2\n", + "\n", + "\n", + "\n", + "\n", + "\n", + "\n", + "PTK2B\n", + "\n", + "PTK2B\n", + "\n", + "\n", + "\n", + "SRC->PTK2B\n", + "\n", + "\n", + "\n", + "\n", + "\n", + "PTK2B->PTK2\n", + "\n", + "\n", + "\n", + "\n", + "\n", + "NOTCH1\n", + "\n", + "NOTCH1\n", + "\n", + "\n", + "\n", + "CDH1\n", + "\n", + "CDH1\n", + "\n", + "\n", + "\n", + "VIM\n", + "\n", + "VIM\n", + "\n", + "\n", + "\n", + "MAP4K4\n", + "\n", + "MAP4K4\n", + "\n", + "\n", + "\n", + "LATS1\n", + "\n", + "LATS1\n", + "\n", + "\n", + "\n", + "LATS2\n", + "\n", + "LATS2\n", + "\n", + "\n", + "\n" + ], + "text/plain": [ + "" + ] + }, + "metadata": {}, + "output_type": "display_data" + } + ], + "source": [ + "visualizer = NetworkVisualizer(new_net1, color_by='effect')\n", + "visualizer.render(output_file=\"new_network\")" + ] + }, + { + "cell_type": "markdown", + "id": "3c1725cc-4c08-4a85-b26c-8f59936e351d", + "metadata": {}, + "source": [ + "#### 2D. Connect disconnected nodes by importing intermediate nodes.\n", + "\n", + "The parameter _*maxlen*_ is used to verify that in the network all the nodes have a distance < than maxlen. \n", + "\n", + "The parameter _*only_signed*_ forces the algorithm to look for just signed interactions. \n", + "\n", + "The parameter _*consensus*_ retrieves those interactions with a sign consensus between the references. \n", + "\n", + "The parameter _*connect_node_when_first_introduced*_, changes the base algorithm, making it look for possible connection between all the disconnected node in the network when a new bridge-gene is introduced in the network." + ] + }, + { + "cell_type": "code", + "execution_count": 8, + "id": "9a07d77b", + "metadata": {}, + "outputs": [ + { + "name": "stdout", + "output_type": "stream", + "text": [ + "looking for paths in the network with length: 0 for node SRC and NOTCH1\n", + "looking for paths in the network with length: 1 for node SRC and NOTCH1\n", + "looking for paths in the network with length: 2 for node SRC and NOTCH1\n", + "looking for paths in the network with length: 3 for node SRC and NOTCH1\n", + "looking for paths in the network with length: 4 for node SRC and NOTCH1\n", + "looking for paths in the network with length: 5 for node SRC and NOTCH1\n", + "looking for paths in the network with length: 6 for node SRC and NOTCH1\n", + "i_search = 3\n", + "Looking for paths with length: 0 for node SRC and NOTCH1\n", + "i_search = 3\n", + "Looking for paths with length: 1 for node SRC and NOTCH1\n", + "i_search = 3\n", + "Looking for paths with length: 2 for node SRC and NOTCH1\n", + "[['SRC', 'CTNNB1', 'NOTCH1'], ['SRC', 'DAB1', 'NOTCH1']]\n", + "P12931 P35222\n", + "P35222 P46531\n", + "P12931 O75553\n", + "O75553 P46531\n", + "P12931 Q05397\n", + "P12931 P19022\n", + "P12931 Q14289\n", + "P12931 P35222\n", + "P12931 O75553\n", + "P35222 P46531\n", + "O75553 P46531\n", + "Q14289 Q05397\n", + "P12830 P35222\n", + "P19022 P35222\n", + "looking for paths in the network with length: 0 for node SRC and PTK2\n", + "looking for paths in the network with length: 1 for node SRC and PTK2\n", + "Found a path!\n", + "[['SRC', 'PTK2']]\n", + "looking for paths in the network with length: 0 for node SRC and CDH1\n", + "looking for paths in the network with length: 1 for node SRC and CDH1\n", + "looking for paths in the network with length: 2 for node SRC and CDH1\n", + "looking for paths in the network with length: 3 for node SRC and CDH1\n", + "looking for paths in the network with length: 4 for node SRC and CDH1\n", + "looking for paths in the network with length: 5 for node SRC and CDH1\n", + "looking for paths in the network with length: 6 for node SRC and CDH1\n", + "i_search = 3\n", + "Looking for paths with length: 0 for node SRC and CDH1\n", + "i_search = 3\n", + "Looking for paths with length: 1 for node SRC and CDH1\n", + "i_search = 3\n", + "Looking for paths with length: 2 for node SRC and CDH1\n", + "[['SRC', 'MET', 'CDH1'], ['SRC', 'PRKD1', 'CDH1'], ['SRC', 'CTNND1', 'CDH1']]\n", + "P12931 P08581\n", + "P08581 P12830\n", + "P12931 Q15139\n", + "Q15139 P12830\n", + "P12931 O60716\n", + "O60716 P12830\n", + "P12931 Q05397\n", + "P12931 P19022\n", + "P12931 Q14289\n", + "P12931 P35222\n", + "P12931 O75553\n", + "P12931 P08581\n", + "P12931 Q15139\n", + "P12931 O60716\n", + "P35222 P46531\n", + "O75553 P46531\n", + "Q14289 Q05397\n", + "P08581 Q05397\n", + "P12830 P35222\n", + "P08581 P12830\n", + "Q15139 P12830\n", + "O60716 P12830\n", + "P19022 P35222\n", + "O60716 P19022\n", + "Q15139 P35222\n", + "looking for paths in the network with length: 0 for node SRC and CDH2\n", + "looking for paths in the network with length: 1 for node SRC and CDH2\n", + "Found a path!\n", + "[['SRC', 'CDH2']]\n", + "looking for paths in the network with length: 0 for node SRC and VIM\n", + "looking for paths in the network with length: 1 for node SRC and VIM\n", + "looking for paths in the network with length: 2 for node SRC and VIM\n", + "looking for paths in the network with length: 3 for node SRC and VIM\n", + "looking for paths in the network with length: 4 for node SRC and VIM\n", + "looking for paths in the network with length: 5 for node SRC and VIM\n", + "looking for paths in the network with length: 6 for node SRC and VIM\n", + "i_search = 3\n", + "Looking for paths with length: 0 for node SRC and VIM\n", + "i_search = 3\n", + "Looking for paths with length: 1 for node SRC and VIM\n", + "i_search = 3\n", + "Looking for paths with length: 2 for node SRC and VIM\n", + "[['SRC', 'PAK2', 'VIM']]\n", + "P12931 Q13177\n", + "Q13177 P08670\n", + "P12931 Q05397\n", + "P12931 P19022\n", + "P12931 Q14289\n", + "P12931 P35222\n", + "P12931 O75553\n", + "P12931 P08581\n", + "P12931 Q15139\n", + "P12931 O60716\n", + "P12931 Q13177\n", + "P35222 P46531\n", + "O75553 P46531\n", + "Q14289 Q05397\n", + "P08581 Q05397\n", + "P12830 P35222\n", + "P08581 P12830\n", + "Q15139 P12830\n", + "O60716 P12830\n", + "P19022 P35222\n", + "O60716 P19022\n", + "Q13177 P08670\n", + "Q15139 P35222\n", + "looking for paths in the network with length: 0 for node SRC and MAP4K4\n", + "looking for paths in the network with length: 1 for node SRC and MAP4K4\n", + "looking for paths in the network with length: 2 for node SRC and MAP4K4\n", + "looking for paths in the network with length: 3 for node SRC and MAP4K4\n", + "looking for paths in the network with length: 4 for node SRC and MAP4K4\n", + "looking for paths in the network with length: 5 for node SRC and MAP4K4\n", + "looking for paths in the network with length: 6 for node SRC and MAP4K4\n", + "i_search = 3\n", + "Looking for paths with length: 0 for node SRC and MAP4K4\n", + "i_search = 3\n", + "Looking for paths with length: 1 for node SRC and MAP4K4\n", + "i_search = 3\n", + "Looking for paths with length: 2 for node SRC and MAP4K4\n", + "i_search = 3\n", + "Looking for paths with length: 3 for node SRC and MAP4K4\n", + "[['SRC', 'MAPK8', 'MAP3K7', 'MAP4K4'], ['SRC', 'MAPK8', 'MAP3K1', 'MAP4K4']]\n", + "P45983 P12931\n", + "O43318 P45983\n", + "O95819 O43318\n", + "P45983 P12931\n", + "Q13233 P45983\n", + "O95819 Q13233\n", + "P12931 Q05397\n", + "P12931 P19022\n", + "P12931 Q14289\n", + "P12931 P35222\n", + "P12931 O75553\n", + "P12931 P08581\n", + "P12931 Q15139\n", + "P12931 O60716\n", + "P12931 Q13177\n", + "P45983 P12931\n", + "P35222 P46531\n", + "O75553 P46531\n", + "Q14289 Q05397\n", + "P08581 Q05397\n", + "P12830 P35222\n", + "P08581 P12830\n", + "Q15139 P12830\n", + "O60716 P12830\n", + "P19022 P35222\n", + "O60716 P19022\n", + "Q13177 P08670\n", + "O95819 O43318\n", + "O95819 Q13233\n", + "Q15139 P35222\n", + "O43318 P45983\n", + "Q13233 P45983\n", + "looking for paths in the network with length: 0 for node SRC and LATS1\n", + "looking for paths in the network with length: 1 for node SRC and LATS1\n", + "looking for paths in the network with length: 2 for node SRC and LATS1\n", + "looking for paths in the network with length: 3 for node SRC and LATS1\n", + "looking for paths in the network with length: 4 for node SRC and LATS1\n", + "looking for paths in the network with length: 5 for node SRC and LATS1\n", + "looking for paths in the network with length: 6 for node SRC and LATS1\n", + "i_search = 3\n", + "Looking for paths with length: 0 for node SRC and LATS1\n", + "i_search = 3\n", + "Looking for paths with length: 1 for node SRC and LATS1\n", + "i_search = 3\n", + "Looking for paths with length: 2 for node SRC and LATS1\n", + "i_search = 3\n", + "Looking for paths with length: 3 for node SRC and LATS1\n", + "[['SRC', 'RAF1', 'STK3', 'LATS1'], ['SRC', 'RAF1', 'STK4', 'LATS1'], ['SRC', 'PAK2', 'NF2', 'LATS1']]\n", + "P12931 P04049\n", + "P04049 Q13188\n", + "Q13188 O95835\n", + "P12931 P04049\n", + "P04049 Q13043\n", + "Q13043 O95835\n", + "P12931 Q13177\n", + "Q13177 P35240\n", + "P35240 O95835\n", + "P12931 Q05397\n", + "P12931 P19022\n", + "P12931 Q14289\n", + "P12931 P35222\n", + "P12931 O75553\n", + "P12931 P08581\n", + "P12931 Q15139\n", + "P12931 O60716\n", + "P12931 Q13177\n", + "P45983 P12931\n", + "P12931 P04049\n", + "P35222 P46531\n", + "O75553 P46531\n", + "Q14289 Q05397\n", + "P08581 Q05397\n", + "P12830 P35222\n", + "P08581 P12830\n", + "Q15139 P12830\n", + "O60716 P12830\n", + "P19022 P35222\n", + "O60716 P19022\n", + "Q13177 P08670\n", + "O95819 O43318\n", + "O95819 Q13233\n", + "Q13188 O95835\n", + "Q13043 O95835\n", + "P35240 O95835\n", + "Q13188 Q9NRM7\n", + "Q13043 Q9NRM7\n", + "P35240 Q9NRM7\n", + "Q15139 P35222\n", + "Q13177 P04049\n", + "Q13177 P35240\n", + "O43318 P45983\n", + "Q13233 P45983\n", + "P45983 Q13043\n", + "P04049 Q13188\n", + "P04049 Q13043\n", + "P35240 Q13188\n", + "P35240 Q13043\n", + "looking for paths in the network with length: 0 for node SRC and LATS2\n", + "looking for paths in the network with length: 1 for node SRC and LATS2\n", + "looking for paths in the network with length: 2 for node SRC and LATS2\n", + "looking for paths in the network with length: 3 for node SRC and LATS2\n", + "Found a path!\n", + "[['SRC', 'PAK2', 'NF2', 'LATS2'], ['SRC', 'RAF1', 'STK3', 'LATS2'], ['SRC', 'RAF1', 'STK4', 'LATS2']]\n", + "looking for paths in the network with length: 0 for node SRC and PTK2B\n", + "looking for paths in the network with length: 1 for node SRC and PTK2B\n", + "Found a path!\n", + "[['SRC', 'PTK2B']]\n", + "looking for paths in the network with length: 0 for node NOTCH1 and PTK2\n", + "looking for paths in the network with length: 1 for node NOTCH1 and PTK2\n", + "looking for paths in the network with length: 2 for node NOTCH1 and PTK2\n", + "looking for paths in the network with length: 3 for node NOTCH1 and PTK2\n", + "looking for paths in the network with length: 4 for node NOTCH1 and PTK2\n", + "looking for paths in the network with length: 5 for node NOTCH1 and PTK2\n", + "looking for paths in the network with length: 6 for node NOTCH1 and PTK2\n", + "i_search = 3\n", + "Looking for paths with length: 0 for node NOTCH1 and PTK2\n", + "i_search = 3\n", + "Looking for paths with length: 1 for node NOTCH1 and PTK2\n", + "i_search = 3\n", + "Looking for paths with length: 2 for node NOTCH1 and PTK2\n", + "i_search = 3\n", + "Looking for paths with length: 3 for node NOTCH1 and PTK2\n", + "[['NOTCH1', 'SMAD3', 'BCAR1', 'PTK2'], ['NOTCH1', 'LCK', 'PTPRH', 'PTK2']]\n", + "P84022 P46531\n", + "P56945 P84022\n", + "Q05397 P56945\n", + "P06239 P46531\n", + "Q9HD43 P06239\n", + "Q9HD43 Q05397\n", + "P12931 Q05397\n", + "P12931 P19022\n", + "P12931 Q14289\n", + "P12931 P35222\n", + "P12931 O75553\n", + "P12931 P08581\n", + "P12931 Q15139\n", + "P12931 O60716\n", + "P12931 Q13177\n", + "P45983 P12931\n", + "P12931 P04049\n", + "P12931 P56945\n", + "Q9HD43 P12931\n", + "P35222 P46531\n", + "O75553 P46531\n", + "P84022 P46531\n", + "P06239 P46531\n", + "Q14289 Q05397\n", + "P08581 Q05397\n", + "Q05397 P56945\n", + "Q05397 Q9HD43\n", + "Q9HD43 Q05397\n", + "P12830 P35222\n", + "P08581 P12830\n", + "Q15139 P12830\n", + "O60716 P12830\n", + "P19022 P35222\n", + "O60716 P19022\n", + "Q13177 P08670\n", + "O95819 O43318\n", + "O95819 Q13233\n", + "Q13188 O95835\n", + "Q13043 O95835\n", + "P35240 O95835\n", + "Q13188 Q9NRM7\n", + "Q13043 Q9NRM7\n", + "P35240 Q9NRM7\n", + "Q15139 P35222\n", + "Q13177 P04049\n", + "Q13177 P35240\n", + "O43318 P45983\n", + "Q13233 P45983\n", + "P45983 Q13043\n", + "P45983 P84022\n", + "O43318 P84022\n", + "P04049 Q13188\n", + "P04049 Q13043\n", + "P06239 P04049\n", + "P35240 Q13188\n", + "P35240 Q13043\n", + "P56945 P84022\n", + "Q9HD43 P56945\n", + "Q9HD43 P06239\n", + "looking for paths in the network with length: 0 for node NOTCH1 and CDH1\n", + "looking for paths in the network with length: 1 for node NOTCH1 and CDH1\n", + "looking for paths in the network with length: 2 for node NOTCH1 and CDH1\n", + "Found a path!\n", + "[['NOTCH1', 'CTNNB1', 'CDH1']]\n", + "looking for paths in the network with length: 0 for node NOTCH1 and CDH2\n", + "looking for paths in the network with length: 1 for node NOTCH1 and CDH2\n", + "looking for paths in the network with length: 2 for node NOTCH1 and CDH2\n", + "Found a path!\n", + "[['NOTCH1', 'CTNNB1', 'CDH2']]\n", + "looking for paths in the network with length: 0 for node NOTCH1 and VIM\n", + "looking for paths in the network with length: 1 for node NOTCH1 and VIM\n", + "looking for paths in the network with length: 2 for node NOTCH1 and VIM\n", + "looking for paths in the network with length: 3 for node NOTCH1 and VIM\n", + "looking for paths in the network with length: 4 for node NOTCH1 and VIM\n", + "looking for paths in the network with length: 5 for node NOTCH1 and VIM\n", + "looking for paths in the network with length: 6 for node NOTCH1 and VIM\n", + "i_search = 3\n", + "Looking for paths with length: 0 for node NOTCH1 and VIM\n", + "i_search = 3\n", + "Looking for paths with length: 1 for node NOTCH1 and VIM\n", + "i_search = 3\n", + "Looking for paths with length: 2 for node NOTCH1 and VIM\n", + "i_search = 3\n", + "Looking for paths with length: 3 for node NOTCH1 and VIM\n", + "looking for paths in the network with length: 0 for node NOTCH1 and MAP4K4\n", + "looking for paths in the network with length: 1 for node NOTCH1 and MAP4K4\n", + "looking for paths in the network with length: 2 for node NOTCH1 and MAP4K4\n", + "looking for paths in the network with length: 3 for node NOTCH1 and MAP4K4\n", + "Found a path!\n", + "[['NOTCH1', 'SMAD3', 'MAP3K7', 'MAP4K4']]\n", + "looking for paths in the network with length: 0 for node NOTCH1 and LATS1\n", + "looking for paths in the network with length: 1 for node NOTCH1 and LATS1\n", + "looking for paths in the network with length: 2 for node NOTCH1 and LATS1\n", + "looking for paths in the network with length: 3 for node NOTCH1 and LATS1\n", + "looking for paths in the network with length: 4 for node NOTCH1 and LATS1\n", + "looking for paths in the network with length: 5 for node NOTCH1 and LATS1\n", + "looking for paths in the network with length: 6 for node NOTCH1 and LATS1\n", + "i_search = 3\n", + "Looking for paths with length: 0 for node NOTCH1 and LATS1\n", + "i_search = 3\n", + "Looking for paths with length: 1 for node NOTCH1 and LATS1\n", + "i_search = 3\n", + "Looking for paths with length: 2 for node NOTCH1 and LATS1\n", + "i_search = 3\n", + "Looking for paths with length: 3 for node NOTCH1 and LATS1\n", + "[['NOTCH1', 'SMAD3', 'WWTR1', 'LATS1'], ['NOTCH1', 'CTNNB1', 'YAP1', 'LATS1'], ['NOTCH1', 'RUNX2', 'WWTR1', 'LATS1'], ['NOTCH1', 'RUNX2', 'YAP1', 'LATS1']]\n", + "P84022 P46531\n", + "Q9GZV5 P84022\n", + "O95835 Q9GZV5\n", + "P35222 P46531\n", + "P46937 P35222\n", + "O95835 P46937\n", + "Q13950 P46531\n", + "Q9GZV5 Q13950\n", + "O95835 Q9GZV5\n", + "Q13950 P46531\n", + "P46937 Q13950\n", + "O95835 P46937\n", + "P12931 Q05397\n", + "P12931 P19022\n", + "P12931 Q14289\n", + "P12931 P35222\n", + "P12931 O75553\n", + "P12931 P08581\n", + "P12931 Q15139\n", + "P12931 O60716\n", + "P12931 Q13177\n", + "P45983 P12931\n", + "P12931 P04049\n", + "P12931 P56945\n", + "Q9HD43 P12931\n", + "P35222 P46531\n", + "O75553 P46531\n", + "P84022 P46531\n", + "P06239 P46531\n", + "Q13950 P46531\n", + "Q14289 Q05397\n", + "P08581 Q05397\n", + "Q05397 P56945\n", + "Q05397 Q9HD43\n", + "Q9HD43 Q05397\n", + "P12830 P35222\n", + "P08581 P12830\n", + "Q15139 P12830\n", + "O60716 P12830\n", + "P19022 P35222\n", + "O60716 P19022\n", + "Q13177 P08670\n", + "O95819 O43318\n", + "O95819 Q13233\n", + "Q13188 O95835\n", + "Q13043 O95835\n", + "P35240 O95835\n", + "O95835 Q9GZV5\n", + "O95835 P46937\n", + "Q13188 Q9NRM7\n", + "Q13043 Q9NRM7\n", + "P35240 Q9NRM7\n", + "Q9NRM7 Q9GZV5\n", + "Q9NRM7 P46937\n", + "Q15139 P35222\n", + "P46937 P35222\n", + "Q13177 P04049\n", + "Q13177 P35240\n", + "O43318 P45983\n", + "Q13233 P45983\n", + "P45983 Q13043\n", + "P45983 P84022\n", + "O43318 P84022\n", + "P04049 Q13188\n", + "P04049 Q13043\n", + "P06239 P04049\n", + "P35240 Q13188\n", + "P35240 Q13043\n", + "P56945 P84022\n", + "Q9GZV5 P84022\n", + "P84022 Q13950\n", + "Q9HD43 P56945\n", + "Q9HD43 P06239\n", + "Q9GZV5 Q13950\n", + "P46937 Q13950\n", + "looking for paths in the network with length: 0 for node NOTCH1 and LATS2\n", + "looking for paths in the network with length: 1 for node NOTCH1 and LATS2\n", + "looking for paths in the network with length: 2 for node NOTCH1 and LATS2\n", + "looking for paths in the network with length: 3 for node NOTCH1 and LATS2\n", + "Found a path!\n", + "[['NOTCH1', 'SMAD3', 'WWTR1', 'LATS2'], ['NOTCH1', 'CTNNB1', 'YAP1', 'LATS2'], ['NOTCH1', 'RUNX2', 'WWTR1', 'LATS2'], ['NOTCH1', 'RUNX2', 'YAP1', 'LATS2']]\n", + "looking for paths in the network with length: 0 for node NOTCH1 and PTK2B\n", + "looking for paths in the network with length: 1 for node NOTCH1 and PTK2B\n", + "looking for paths in the network with length: 2 for node NOTCH1 and PTK2B\n", + "looking for paths in the network with length: 3 for node NOTCH1 and PTK2B\n", + "looking for paths in the network with length: 4 for node NOTCH1 and PTK2B\n", + "Found a path!\n", + "[['NOTCH1', 'SMAD3', 'BCAR1', 'PTK2', 'PTK2B'], ['NOTCH1', 'LCK', 'PTPRH', 'PTK2', 'PTK2B']]\n", + "looking for paths in the network with length: 0 for node PTK2 and CDH1\n", + "looking for paths in the network with length: 1 for node PTK2 and CDH1\n", + "looking for paths in the network with length: 2 for node PTK2 and CDH1\n", + "looking for paths in the network with length: 3 for node PTK2 and CDH1\n", + "looking for paths in the network with length: 4 for node PTK2 and CDH1\n", + "Found a path!\n", + "[['PTK2', 'PTPRH', 'SRC', 'PRKD1', 'CDH1'], ['PTK2', 'PTPRH', 'SRC', 'CTNND1', 'CDH1'], ['PTK2', 'PTPRH', 'SRC', 'MET', 'CDH1']]\n", + "looking for paths in the network with length: 0 for node PTK2 and CDH2\n", + "looking for paths in the network with length: 1 for node PTK2 and CDH2\n", + "looking for paths in the network with length: 2 for node PTK2 and CDH2\n", + "looking for paths in the network with length: 3 for node PTK2 and CDH2\n", + "Found a path!\n", + "[['PTK2', 'PTPRH', 'SRC', 'CDH2']]\n", + "looking for paths in the network with length: 0 for node PTK2 and VIM\n", + "looking for paths in the network with length: 1 for node PTK2 and VIM\n", + "looking for paths in the network with length: 2 for node PTK2 and VIM\n", + "looking for paths in the network with length: 3 for node PTK2 and VIM\n", + "looking for paths in the network with length: 4 for node PTK2 and VIM\n", + "Found a path!\n", + "[['PTK2', 'PTPRH', 'SRC', 'PAK2', 'VIM']]\n", + "looking for paths in the network with length: 0 for node PTK2 and MAP4K4\n", + "looking for paths in the network with length: 1 for node PTK2 and MAP4K4\n", + "looking for paths in the network with length: 2 for node PTK2 and MAP4K4\n", + "looking for paths in the network with length: 3 for node PTK2 and MAP4K4\n", + "looking for paths in the network with length: 4 for node PTK2 and MAP4K4\n", + "Found a path!\n", + "[['PTK2', 'SRC', 'MAPK8', 'MAP3K7', 'MAP4K4'], ['PTK2', 'SRC', 'MAPK8', 'MAP3K1', 'MAP4K4']]\n", + "looking for paths in the network with length: 0 for node PTK2 and LATS1\n", + "looking for paths in the network with length: 1 for node PTK2 and LATS1\n", + "looking for paths in the network with length: 2 for node PTK2 and LATS1\n", + "looking for paths in the network with length: 3 for node PTK2 and LATS1\n", + "looking for paths in the network with length: 4 for node PTK2 and LATS1\n", + "looking for paths in the network with length: 5 for node PTK2 and LATS1\n", + "Found a path!\n", + "[['PTK2', 'PTPRH', 'SRC', 'PAK2', 'NF2', 'LATS1'], ['PTK2', 'PTPRH', 'SRC', 'RAF1', 'STK3', 'LATS1'], ['PTK2', 'PTPRH', 'SRC', 'RAF1', 'STK4', 'LATS1'], ['PTK2', 'PTPRH', 'LCK', 'RAF1', 'STK3', 'LATS1'], ['PTK2', 'PTPRH', 'LCK', 'RAF1', 'STK4', 'LATS1']]\n", + "looking for paths in the network with length: 0 for node PTK2 and LATS2\n", + "looking for paths in the network with length: 1 for node PTK2 and LATS2\n", + "looking for paths in the network with length: 2 for node PTK2 and LATS2\n", + "looking for paths in the network with length: 3 for node PTK2 and LATS2\n", + "looking for paths in the network with length: 4 for node PTK2 and LATS2\n", + "looking for paths in the network with length: 5 for node PTK2 and LATS2\n", + "Found a path!\n", + "[['PTK2', 'PTPRH', 'SRC', 'PAK2', 'NF2', 'LATS2'], ['PTK2', 'PTPRH', 'SRC', 'RAF1', 'STK3', 'LATS2'], ['PTK2', 'PTPRH', 'SRC', 'RAF1', 'STK4', 'LATS2'], ['PTK2', 'PTPRH', 'LCK', 'RAF1', 'STK3', 'LATS2'], ['PTK2', 'PTPRH', 'LCK', 'RAF1', 'STK4', 'LATS2']]\n", + "looking for paths in the network with length: 0 for node PTK2 and PTK2B\n", + "looking for paths in the network with length: 1 for node PTK2 and PTK2B\n", + "Found a path!\n", + "[['PTK2', 'PTK2B']]\n", + "looking for paths in the network with length: 0 for node CDH1 and CDH2\n", + "looking for paths in the network with length: 1 for node CDH1 and CDH2\n", + "looking for paths in the network with length: 2 for node CDH1 and CDH2\n", + "looking for paths in the network with length: 3 for node CDH1 and CDH2\n", + "looking for paths in the network with length: 4 for node CDH1 and CDH2\n", + "looking for paths in the network with length: 5 for node CDH1 and CDH2\n", + "looking for paths in the network with length: 6 for node CDH1 and CDH2\n", + "i_search = 3\n", + "Looking for paths with length: 0 for node CDH1 and CDH2\n", + "i_search = 3\n", + "Looking for paths with length: 1 for node CDH1 and CDH2\n", + "i_search = 3\n", + "Looking for paths with length: 2 for node CDH1 and CDH2\n", + "i_search = 3\n", + "Looking for paths with length: 3 for node CDH1 and CDH2\n", + "[['CDH1', 'EGFR', 'CTNND1', 'CDH2']]\n", + "P12830 P00533\n", + "P00533 O60716\n", + "O60716 P19022\n", + "P12931 Q05397\n", + "P12931 P19022\n", + "P12931 Q14289\n", + "P12931 P35222\n", + "P12931 O75553\n", + "P12931 P08581\n", + "P12931 Q15139\n", + "P12931 O60716\n", + "P12931 Q13177\n", + "P45983 P12931\n", + "P12931 P04049\n", + "P12931 P56945\n", + "Q9HD43 P12931\n", + "P12931 P00533\n", + "P35222 P46531\n", + "O75553 P46531\n", + "P84022 P46531\n", + "P06239 P46531\n", + "Q13950 P46531\n", + "Q14289 Q05397\n", + "P08581 Q05397\n", + "Q05397 P56945\n", + "Q05397 Q9HD43\n", + "Q9HD43 Q05397\n", + "P00533 Q05397\n", + "P12830 P35222\n", + "P08581 P12830\n", + "Q15139 P12830\n", + "O60716 P12830\n", + "P12830 P00533\n", + "P19022 P35222\n", + "O60716 P19022\n", + "Q13177 P08670\n", + "O95819 O43318\n", + "O95819 Q13233\n", + "Q13188 O95835\n", + "Q13043 O95835\n", + "P35240 O95835\n", + "O95835 Q9GZV5\n", + "O95835 P46937\n", + "Q13188 Q9NRM7\n", + "Q13043 Q9NRM7\n", + "P35240 Q9NRM7\n", + "Q9NRM7 Q9GZV5\n", + "Q9NRM7 P46937\n", + "Q14289 P00533\n", + "Q15139 P35222\n", + "P46937 P35222\n", + "P00533 P35222\n", + "Q15139 P00533\n", + "P00533 O60716\n", + "Q13177 P04049\n", + "Q13177 P35240\n", + "O43318 P45983\n", + "Q13233 P45983\n", + "P45983 Q13043\n", + "P45983 P84022\n", + "O43318 P84022\n", + "P04049 Q13188\n", + "P04049 Q13043\n", + "P06239 P04049\n", + "P35240 Q13188\n", + "P35240 Q13043\n", + "P56945 P84022\n", + "Q9GZV5 P84022\n", + "P84022 Q13950\n", + "Q9HD43 P56945\n", + "P00533 P56945\n", + "Q9HD43 P06239\n", + "Q9GZV5 Q13950\n", + "P46937 Q13950\n", + "looking for paths in the network with length: 0 for node CDH1 and VIM\n", + "looking for paths in the network with length: 1 for node CDH1 and VIM\n", + "looking for paths in the network with length: 2 for node CDH1 and VIM\n", + "looking for paths in the network with length: 3 for node CDH1 and VIM\n", + "looking for paths in the network with length: 4 for node CDH1 and VIM\n", + "looking for paths in the network with length: 5 for node CDH1 and VIM\n", + "looking for paths in the network with length: 6 for node CDH1 and VIM\n", + "Found a path!\n", + "[['CDH1', 'EGFR', 'PTK2', 'PTPRH', 'SRC', 'PAK2', 'VIM']]\n", + "looking for paths in the network with length: 0 for node CDH1 and MAP4K4\n", + "looking for paths in the network with length: 1 for node CDH1 and MAP4K4\n", + "looking for paths in the network with length: 2 for node CDH1 and MAP4K4\n", + "looking for paths in the network with length: 3 for node CDH1 and MAP4K4\n", + "looking for paths in the network with length: 4 for node CDH1 and MAP4K4\n", + "looking for paths in the network with length: 5 for node CDH1 and MAP4K4\n", + "Found a path!\n", + "[['CDH1', 'CTNND1', 'SRC', 'MAPK8', 'MAP3K7', 'MAP4K4'], ['CDH1', 'CTNND1', 'SRC', 'MAPK8', 'MAP3K1', 'MAP4K4'], ['CDH1', 'PRKD1', 'SRC', 'MAPK8', 'MAP3K7', 'MAP4K4'], ['CDH1', 'PRKD1', 'SRC', 'MAPK8', 'MAP3K1', 'MAP4K4'], ['CDH1', 'MET', 'SRC', 'MAPK8', 'MAP3K7', 'MAP4K4'], ['CDH1', 'MET', 'SRC', 'MAPK8', 'MAP3K1', 'MAP4K4']]\n", + "looking for paths in the network with length: 0 for node CDH1 and LATS1\n", + "looking for paths in the network with length: 1 for node CDH1 and LATS1\n", + "looking for paths in the network with length: 2 for node CDH1 and LATS1\n", + "looking for paths in the network with length: 3 for node CDH1 and LATS1\n", + "looking for paths in the network with length: 4 for node CDH1 and LATS1\n", + "looking for paths in the network with length: 5 for node CDH1 and LATS1\n", + "looking for paths in the network with length: 6 for node CDH1 and LATS1\n", + "i_search = 3\n", + "Looking for paths with length: 0 for node CDH1 and LATS1\n", + "i_search = 3\n", + "Looking for paths with length: 1 for node CDH1 and LATS1\n", + "i_search = 3\n", + "Looking for paths with length: 2 for node CDH1 and LATS1\n", + "i_search = 3\n", + "Looking for paths with length: 3 for node CDH1 and LATS1\n", + "looking for paths in the network with length: 0 for node CDH1 and LATS2\n", + "looking for paths in the network with length: 1 for node CDH1 and LATS2\n", + "looking for paths in the network with length: 2 for node CDH1 and LATS2\n", + "looking for paths in the network with length: 3 for node CDH1 and LATS2\n", + "looking for paths in the network with length: 4 for node CDH1 and LATS2\n", + "looking for paths in the network with length: 5 for node CDH1 and LATS2\n", + "looking for paths in the network with length: 6 for node CDH1 and LATS2\n", + "i_search = 3\n", + "Looking for paths with length: 0 for node CDH1 and LATS2\n", + "i_search = 3\n", + "Looking for paths with length: 1 for node CDH1 and LATS2\n", + "i_search = 3\n", + "Looking for paths with length: 2 for node CDH1 and LATS2\n", + "i_search = 3\n", + "Looking for paths with length: 3 for node CDH1 and LATS2\n", + "looking for paths in the network with length: 0 for node CDH1 and PTK2B\n", + "looking for paths in the network with length: 1 for node CDH1 and PTK2B\n", + "looking for paths in the network with length: 2 for node CDH1 and PTK2B\n", + "looking for paths in the network with length: 3 for node CDH1 and PTK2B\n", + "Found a path!\n", + "[['CDH1', 'CTNND1', 'EGFR', 'PTK2B']]\n", + "looking for paths in the network with length: 0 for node CDH2 and VIM\n", + "looking for paths in the network with length: 1 for node CDH2 and VIM\n", + "looking for paths in the network with length: 2 for node CDH2 and VIM\n", + "looking for paths in the network with length: 3 for node CDH2 and VIM\n", + "looking for paths in the network with length: 4 for node CDH2 and VIM\n", + "looking for paths in the network with length: 5 for node CDH2 and VIM\n", + "looking for paths in the network with length: 6 for node CDH2 and VIM\n", + "i_search = 3\n", + "Looking for paths with length: 0 for node CDH2 and VIM\n", + "i_search = 3\n", + "Looking for paths with length: 1 for node CDH2 and VIM\n", + "i_search = 3\n", + "Looking for paths with length: 2 for node CDH2 and VIM\n", + "i_search = 3\n", + "Looking for paths with length: 3 for node CDH2 and VIM\n", + "looking for paths in the network with length: 0 for node CDH2 and MAP4K4\n", + "looking for paths in the network with length: 1 for node CDH2 and MAP4K4\n", + "looking for paths in the network with length: 2 for node CDH2 and MAP4K4\n", + "looking for paths in the network with length: 3 for node CDH2 and MAP4K4\n", + "looking for paths in the network with length: 4 for node CDH2 and MAP4K4\n", + "Found a path!\n", + "[['CDH2', 'SRC', 'MAPK8', 'MAP3K7', 'MAP4K4'], ['CDH2', 'SRC', 'MAPK8', 'MAP3K1', 'MAP4K4']]\n", + "looking for paths in the network with length: 0 for node CDH2 and LATS1\n", + "looking for paths in the network with length: 1 for node CDH2 and LATS1\n", + "looking for paths in the network with length: 2 for node CDH2 and LATS1\n", + "looking for paths in the network with length: 3 for node CDH2 and LATS1\n", + "looking for paths in the network with length: 4 for node CDH2 and LATS1\n", + "looking for paths in the network with length: 5 for node CDH2 and LATS1\n", + "looking for paths in the network with length: 6 for node CDH2 and LATS1\n", + "i_search = 3\n", + "Looking for paths with length: 0 for node CDH2 and LATS1\n", + "i_search = 3\n", + "Looking for paths with length: 1 for node CDH2 and LATS1\n", + "i_search = 3\n", + "Looking for paths with length: 2 for node CDH2 and LATS1\n", + "i_search = 3\n", + "Looking for paths with length: 3 for node CDH2 and LATS1\n", + "looking for paths in the network with length: 0 for node CDH2 and LATS2\n", + "looking for paths in the network with length: 1 for node CDH2 and LATS2\n", + "looking for paths in the network with length: 2 for node CDH2 and LATS2\n", + "looking for paths in the network with length: 3 for node CDH2 and LATS2\n", + "looking for paths in the network with length: 4 for node CDH2 and LATS2\n", + "looking for paths in the network with length: 5 for node CDH2 and LATS2\n", + "looking for paths in the network with length: 6 for node CDH2 and LATS2\n", + "i_search = 3\n", + "Looking for paths with length: 0 for node CDH2 and LATS2\n", + "i_search = 3\n", + "Looking for paths with length: 1 for node CDH2 and LATS2\n", + "i_search = 3\n", + "Looking for paths with length: 2 for node CDH2 and LATS2\n", + "i_search = 3\n", + "Looking for paths with length: 3 for node CDH2 and LATS2\n", + "looking for paths in the network with length: 0 for node CDH2 and PTK2B\n", + "looking for paths in the network with length: 1 for node CDH2 and PTK2B\n", + "looking for paths in the network with length: 2 for node CDH2 and PTK2B\n", + "looking for paths in the network with length: 3 for node CDH2 and PTK2B\n", + "Found a path!\n", + "[['CDH2', 'CTNND1', 'EGFR', 'PTK2B']]\n", + "looking for paths in the network with length: 0 for node VIM and MAP4K4\n", + "looking for paths in the network with length: 1 for node VIM and MAP4K4\n", + "looking for paths in the network with length: 2 for node VIM and MAP4K4\n", + "looking for paths in the network with length: 3 for node VIM and MAP4K4\n", + "looking for paths in the network with length: 4 for node VIM and MAP4K4\n", + "looking for paths in the network with length: 5 for node VIM and MAP4K4\n", + "Found a path!\n", + "[['VIM', 'PAK2', 'SRC', 'MAPK8', 'MAP3K7', 'MAP4K4'], ['VIM', 'PAK2', 'SRC', 'MAPK8', 'MAP3K1', 'MAP4K4']]\n", + "looking for paths in the network with length: 0 for node VIM and LATS1\n", + "looking for paths in the network with length: 1 for node VIM and LATS1\n", + "looking for paths in the network with length: 2 for node VIM and LATS1\n", + "looking for paths in the network with length: 3 for node VIM and LATS1\n", + "looking for paths in the network with length: 4 for node VIM and LATS1\n", + "looking for paths in the network with length: 5 for node VIM and LATS1\n", + "looking for paths in the network with length: 6 for node VIM and LATS1\n", + "i_search = 3\n", + "Looking for paths with length: 0 for node VIM and LATS1\n", + "i_search = 3\n", + "Looking for paths with length: 1 for node VIM and LATS1\n", + "i_search = 3\n", + "Looking for paths with length: 2 for node VIM and LATS1\n", + "i_search = 3\n", + "Looking for paths with length: 3 for node VIM and LATS1\n", + "looking for paths in the network with length: 0 for node VIM and LATS2\n", + "looking for paths in the network with length: 1 for node VIM and LATS2\n", + "looking for paths in the network with length: 2 for node VIM and LATS2\n", + "looking for paths in the network with length: 3 for node VIM and LATS2\n", + "looking for paths in the network with length: 4 for node VIM and LATS2\n", + "looking for paths in the network with length: 5 for node VIM and LATS2\n", + "looking for paths in the network with length: 6 for node VIM and LATS2\n", + "i_search = 3\n", + "Looking for paths with length: 0 for node VIM and LATS2\n", + "i_search = 3\n", + "Looking for paths with length: 1 for node VIM and LATS2\n", + "i_search = 3\n", + "Looking for paths with length: 2 for node VIM and LATS2\n", + "i_search = 3\n", + "Looking for paths with length: 3 for node VIM and LATS2\n", + "looking for paths in the network with length: 0 for node VIM and PTK2B\n", + "looking for paths in the network with length: 1 for node VIM and PTK2B\n", + "looking for paths in the network with length: 2 for node VIM and PTK2B\n", + "looking for paths in the network with length: 3 for node VIM and PTK2B\n", + "looking for paths in the network with length: 4 for node VIM and PTK2B\n", + "looking for paths in the network with length: 5 for node VIM and PTK2B\n", + "Found a path!\n", + "[['VIM', 'PAK2', 'SRC', 'PTPRH', 'PTK2', 'PTK2B']]\n", + "looking for paths in the network with length: 0 for node MAP4K4 and LATS1\n", + "looking for paths in the network with length: 1 for node MAP4K4 and LATS1\n", + "looking for paths in the network with length: 2 for node MAP4K4 and LATS1\n", + "looking for paths in the network with length: 3 for node MAP4K4 and LATS1\n", + "looking for paths in the network with length: 4 for node MAP4K4 and LATS1\n", + "Found a path!\n", + "[['MAP4K4', 'MAP3K7', 'MAPK8', 'STK4', 'LATS1'], ['MAP4K4', 'MAP3K1', 'MAPK8', 'STK4', 'LATS1']]\n", + "looking for paths in the network with length: 0 for node MAP4K4 and LATS2\n", + "looking for paths in the network with length: 1 for node MAP4K4 and LATS2\n", + "looking for paths in the network with length: 2 for node MAP4K4 and LATS2\n", + "looking for paths in the network with length: 3 for node MAP4K4 and LATS2\n", + "looking for paths in the network with length: 4 for node MAP4K4 and LATS2\n", + "Found a path!\n", + "[['MAP4K4', 'MAP3K7', 'MAPK8', 'STK4', 'LATS2'], ['MAP4K4', 'MAP3K1', 'MAPK8', 'STK4', 'LATS2']]\n", + "looking for paths in the network with length: 0 for node MAP4K4 and PTK2B\n", + "looking for paths in the network with length: 1 for node MAP4K4 and PTK2B\n", + "looking for paths in the network with length: 2 for node MAP4K4 and PTK2B\n", + "looking for paths in the network with length: 3 for node MAP4K4 and PTK2B\n", + "looking for paths in the network with length: 4 for node MAP4K4 and PTK2B\n", + "Found a path!\n", + "[['MAP4K4', 'MAP3K7', 'MAPK8', 'SRC', 'PTK2B'], ['MAP4K4', 'MAP3K1', 'MAPK8', 'SRC', 'PTK2B']]\n", + "looking for paths in the network with length: 0 for node LATS1 and LATS2\n", + "looking for paths in the network with length: 1 for node LATS1 and LATS2\n", + "looking for paths in the network with length: 2 for node LATS1 and LATS2\n", + "looking for paths in the network with length: 3 for node LATS1 and LATS2\n", + "looking for paths in the network with length: 4 for node LATS1 and LATS2\n", + "looking for paths in the network with length: 5 for node LATS1 and LATS2\n", + "looking for paths in the network with length: 6 for node LATS1 and LATS2\n", + "i_search = 3\n", + "Looking for paths with length: 0 for node LATS1 and LATS2\n", + "i_search = 3\n", + "Looking for paths with length: 1 for node LATS1 and LATS2\n", + "i_search = 3\n", + "Looking for paths with length: 2 for node LATS1 and LATS2\n", + "i_search = 3\n", + "Looking for paths with length: 3 for node LATS1 and LATS2\n", + "looking for paths in the network with length: 0 for node LATS1 and PTK2B\n", + "looking for paths in the network with length: 1 for node LATS1 and PTK2B\n", + "looking for paths in the network with length: 2 for node LATS1 and PTK2B\n", + "looking for paths in the network with length: 3 for node LATS1 and PTK2B\n", + "looking for paths in the network with length: 4 for node LATS1 and PTK2B\n", + "looking for paths in the network with length: 5 for node LATS1 and PTK2B\n", + "looking for paths in the network with length: 6 for node LATS1 and PTK2B\n", + "Found a path!\n", + "[['LATS1', 'STK3', 'RAF1', 'LCK', 'PTPRH', 'PTK2', 'PTK2B'], ['LATS1', 'STK3', 'RAF1', 'SRC', 'PTPRH', 'PTK2', 'PTK2B'], ['LATS1', 'STK4', 'RAF1', 'LCK', 'PTPRH', 'PTK2', 'PTK2B'], ['LATS1', 'STK4', 'RAF1', 'SRC', 'PTPRH', 'PTK2', 'PTK2B'], ['LATS1', 'NF2', 'PAK2', 'SRC', 'PTPRH', 'PTK2', 'PTK2B']]\n", + "looking for paths in the network with length: 0 for node LATS2 and PTK2B\n", + "looking for paths in the network with length: 1 for node LATS2 and PTK2B\n", + "looking for paths in the network with length: 2 for node LATS2 and PTK2B\n", + "looking for paths in the network with length: 3 for node LATS2 and PTK2B\n", + "looking for paths in the network with length: 4 for node LATS2 and PTK2B\n", + "looking for paths in the network with length: 5 for node LATS2 and PTK2B\n", + "looking for paths in the network with length: 6 for node LATS2 and PTK2B\n", + "Found a path!\n", + "[['LATS2', 'STK3', 'RAF1', 'LCK', 'PTPRH', 'PTK2', 'PTK2B'], ['LATS2', 'STK3', 'RAF1', 'SRC', 'PTPRH', 'PTK2', 'PTK2B'], ['LATS2', 'STK4', 'RAF1', 'LCK', 'PTPRH', 'PTK2', 'PTK2B'], ['LATS2', 'STK4', 'RAF1', 'SRC', 'PTPRH', 'PTK2', 'PTK2B'], ['LATS2', 'NF2', 'PAK2', 'SRC', 'PTPRH', 'PTK2', 'PTK2B']]\n", + "CPU times: user 1min 50s, sys: 22.9 ms, total: 1min 50s\n", + "Wall time: 1min 50s\n" + ] + } + ], + "source": [ + "%%time\n", + "new_net1.complete_connection(mode=\"ALL\", maxlen=6, k_mean=\"tight\", only_signed=True, connect_node_when_first_introduced=True, consensus=True)" + ] + }, + { + "cell_type": "markdown", + "id": "c6510316-2f47-4e71-89e0-b93da0657897", + "metadata": {}, + "source": [ + "#### 2E. Visualize final network" + ] + }, + { + "cell_type": "code", + "execution_count": 9, + "id": "152b9434", + "metadata": {}, + "outputs": [ + { + "data": { + "image/svg+xml": [ + "\n", + "\n", + "\n", + "\n", + "\n", + "\n", + "%3\n", + "\n", + "\n", + "\n", + "SRC\n", + "\n", + "SRC\n", + "\n", + "\n", + "\n", + "PTK2\n", + "\n", + "PTK2\n", + "\n", + "\n", + "\n", + "SRC->PTK2\n", + "\n", + "\n", + "\n", + "\n", + "\n", + "CDH2\n", + "\n", + "CDH2\n", + "\n", + "\n", + "\n", + "SRC->CDH2\n", + "\n", + "\n", + "\n", + "\n", + "\n", + "\n", + "PTK2B\n", + "\n", + "PTK2B\n", + "\n", + "\n", + "\n", + "SRC->PTK2B\n", + "\n", + "\n", + "\n", + "\n", + "\n", + "CTNNB1\n", + "\n", + "CTNNB1\n", + "\n", + "\n", + "\n", + "SRC->CTNNB1\n", + "\n", + "\n", + "\n", + "\n", + "\n", + "DAB1\n", + "\n", + "DAB1\n", + "\n", + "\n", + "\n", + "SRC->DAB1\n", + "\n", + "\n", + "\n", + "\n", + "\n", + "MET\n", + "\n", + "MET\n", + "\n", + "\n", + "\n", + "SRC->MET\n", + "\n", + "\n", + "\n", + "\n", + "\n", + "\n", + "PRKD1\n", + "\n", + "PRKD1\n", + "\n", + "\n", + "\n", + "SRC->PRKD1\n", + "\n", + "\n", + "\n", + "\n", + "\n", + "CTNND1\n", + "\n", + "CTNND1\n", + "\n", + "\n", + "\n", + "SRC->CTNND1\n", + "\n", + "\n", + "\n", + "\n", + "\n", + "PAK2\n", + "\n", + "PAK2\n", + "\n", + "\n", + "\n", + "SRC->PAK2\n", + "\n", + "\n", + "\n", + "\n", + "\n", + "RAF1\n", + "\n", + "RAF1\n", + "\n", + "\n", + "\n", + "SRC->RAF1\n", + "\n", + "\n", + "\n", + "\n", + "\n", + "BCAR1\n", + "\n", + "BCAR1\n", + "\n", + "\n", + "\n", + "SRC->BCAR1\n", + "\n", + "\n", + "\n", + "\n", + "\n", + "EGFR\n", + "\n", + "EGFR\n", + "\n", + "\n", + "\n", + "SRC->EGFR\n", + "\n", + "\n", + "\n", + "\n", + "\n", + "PTK2->BCAR1\n", + "\n", + "\n", + "\n", + "\n", + "\n", + "PTPRH\n", + "\n", + "PTPRH\n", + "\n", + "\n", + "\n", + "PTK2->PTPRH\n", + "\n", + "\n", + "\n", + "\n", + "\n", + "\n", + "CDH2->CTNNB1\n", + "\n", + "\n", + "\n", + "\n", + "\n", + "PTK2B->PTK2\n", + "\n", + "\n", + "\n", + "\n", + "\n", + "PTK2B->EGFR\n", + "\n", + "\n", + "\n", + "\n", + "\n", + "NOTCH1\n", + "\n", + "NOTCH1\n", + "\n", + "\n", + "\n", + "CTNNB1->NOTCH1\n", + "\n", + "\n", + "\n", + "\n", + "\n", + "DAB1->NOTCH1\n", + "\n", + "\n", + "\n", + "\n", + "\n", + "CDH1\n", + "\n", + "CDH1\n", + "\n", + "\n", + "\n", + "CDH1->CTNNB1\n", + "\n", + "\n", + "\n", + "\n", + "\n", + "CDH1->EGFR\n", + "\n", + "\n", + "\n", + "\n", + "\n", + "MET->PTK2\n", + "\n", + "\n", + "\n", + "\n", + "\n", + "MET->CDH1\n", + "\n", + "\n", + "\n", + "\n", + "\n", + "PRKD1->CTNNB1\n", + "\n", + "\n", + "\n", + "\n", + "\n", + "PRKD1->CDH1\n", + "\n", + "\n", + "\n", + "\n", + "\n", + "PRKD1->EGFR\n", + "\n", + "\n", + "\n", + "\n", + "\n", + "CTNND1->CDH2\n", + "\n", + "\n", + "\n", + "\n", + "\n", + "CTNND1->CDH1\n", + "\n", + "\n", + "\n", + "\n", + "\n", + "VIM\n", + "\n", + "VIM\n", + "\n", + "\n", + "\n", + "PAK2->VIM\n", + "\n", + "\n", + "\n", + "\n", + "\n", + "\n", + "PAK2->RAF1\n", + "\n", + "\n", + "\n", + "\n", + "\n", + "NF2\n", + "\n", + "NF2\n", + "\n", + "\n", + "\n", + "PAK2->NF2\n", + "\n", + "\n", + "\n", + "\n", + "\n", + "MAPK8\n", + "\n", + "MAPK8\n", + "\n", + "\n", + "\n", + "MAPK8->SRC\n", + "\n", + "\n", + "\n", + "\n", + "\n", + "STK4\n", + "\n", + "STK4\n", + "\n", + "\n", + "\n", + "MAPK8->STK4\n", + "\n", + "\n", + "\n", + "\n", + "\n", + "SMAD3\n", + "\n", + "SMAD3\n", + "\n", + "\n", + "\n", + "MAPK8->SMAD3\n", + "\n", + "\n", + "\n", + "\n", + "\n", + "MAP3K7\n", + "\n", + "MAP3K7\n", + "\n", + "\n", + "\n", + "MAP3K7->MAPK8\n", + "\n", + "\n", + "\n", + "\n", + "\n", + "MAP3K7->SMAD3\n", + "\n", + "\n", + "\n", + "\n", + "\n", + "\n", + "MAP4K4\n", + "\n", + "MAP4K4\n", + "\n", + "\n", + "\n", + "MAP4K4->MAP3K7\n", + "\n", + "\n", + "\n", + "\n", + "\n", + "MAP3K1\n", + "\n", + "MAP3K1\n", + "\n", + "\n", + "\n", + "MAP4K4->MAP3K1\n", + "\n", + "\n", + "\n", + "\n", + "\n", + "MAP3K1->MAPK8\n", + "\n", + "\n", + "\n", + "\n", + "\n", + "STK3\n", + "\n", + "STK3\n", + "\n", + "\n", + "\n", + "RAF1->STK3\n", + "\n", + "\n", + "\n", + "\n", + "\n", + "\n", + "RAF1->STK4\n", + "\n", + "\n", + "\n", + "\n", + "\n", + "\n", + "LATS1\n", + "\n", + "LATS1\n", + "\n", + "\n", + "\n", + "STK3->LATS1\n", + "\n", + "\n", + "\n", + "\n", + "\n", + "LATS2\n", + "\n", + "LATS2\n", + "\n", + "\n", + "\n", + "STK3->LATS2\n", + "\n", + "\n", + "\n", + "\n", + "\n", + "WWTR1\n", + "\n", + "WWTR1\n", + "\n", + "\n", + "\n", + "LATS1->WWTR1\n", + "\n", + "\n", + "\n", + "\n", + "\n", + "\n", + "YAP1\n", + "\n", + "YAP1\n", + "\n", + "\n", + "\n", + "LATS1->YAP1\n", + "\n", + "\n", + "\n", + "\n", + "\n", + "STK4->LATS1\n", + "\n", + "\n", + "\n", + "\n", + "\n", + "STK4->LATS2\n", + "\n", + "\n", + "\n", + "\n", + "\n", + "NF2->STK3\n", + "\n", + "\n", + "\n", + "\n", + "\n", + "NF2->LATS1\n", + "\n", + "\n", + "\n", + "\n", + "\n", + "NF2->STK4\n", + "\n", + "\n", + "\n", + "\n", + "\n", + "NF2->LATS2\n", + "\n", + "\n", + "\n", + "\n", + "\n", + "LATS2->WWTR1\n", + "\n", + "\n", + "\n", + "\n", + "\n", + "\n", + "LATS2->YAP1\n", + "\n", + "\n", + "\n", + "\n", + "\n", + "\n", + "SMAD3->NOTCH1\n", + "\n", + "\n", + "\n", + "\n", + "\n", + "RUNX2\n", + "\n", + "RUNX2\n", + "\n", + "\n", + "\n", + "SMAD3->RUNX2\n", + "\n", + "\n", + "\n", + "\n", + "\n", + "\n", + "BCAR1->SMAD3\n", + "\n", + "\n", + "\n", + "\n", + "\n", + "\n", + "LCK\n", + "\n", + "LCK\n", + "\n", + "\n", + "\n", + "LCK->NOTCH1\n", + "\n", + "\n", + "\n", + "\n", + "\n", + "LCK->RAF1\n", + "\n", + "\n", + "\n", + "\n", + "\n", + "PTPRH->SRC\n", + "\n", + "\n", + "\n", + "\n", + "\n", + "\n", + "PTPRH->PTK2\n", + "\n", + "\n", + "\n", + "\n", + "\n", + "\n", + "PTPRH->BCAR1\n", + "\n", + "\n", + "\n", + "\n", + "\n", + "\n", + "PTPRH->LCK\n", + "\n", + "\n", + "\n", + "\n", + "\n", + "\n", + "WWTR1->SMAD3\n", + "\n", + "\n", + "\n", + "\n", + "\n", + "WWTR1->RUNX2\n", + "\n", + "\n", + "\n", + "\n", + "\n", + "YAP1->CTNNB1\n", + "\n", + "\n", + "\n", + "\n", + "\n", + "YAP1->RUNX2\n", + "\n", + "\n", + "\n", + "\n", + "\n", + "\n", + "RUNX2->NOTCH1\n", + "\n", + "\n", + "\n", + "\n", + "\n", + "\n", + "EGFR->PTK2\n", + "\n", + "\n", + "\n", + "\n", + "\n", + "EGFR->CTNNB1\n", + "\n", + "\n", + "\n", + "\n", + "\n", + "EGFR->CTNND1\n", + "\n", + "\n", + "\n", + "\n", + "\n", + "\n", + "EGFR->BCAR1\n", + "\n", + "\n", + "\n", + "\n", + "\n", + "\n" + ], + "text/plain": [ + "" + ] + }, + "metadata": {}, + "output_type": "display_data" + } + ], + "source": [ + "#Visualize network\n", + "visualizer1 = NetworkVisualizer(new_net1, color_by='effect')\n", + "visualizer1.render(output_file='network2')" + ] + }, + { + "cell_type": "code", + "execution_count": null, + "id": "80b84e81-abc2-4aae-ad1c-3ebf00355b98", + "metadata": {}, + "outputs": [], + "source": [ + "#Visualize a specific nodes and \n", + "visualizer1 = NetworkVisualizer(new_net1, predefined_node = \"SRC\",color_by='effect')\n", + "visualizer1.render(output_file='network2')" + ] + }, + { + "cell_type": "code", + "execution_count": 15, + "id": "0aa6d076-5310-462e-aa0e-f69da822b962", + "metadata": {}, + "outputs": [ + { + "data": { + "text/html": [ + "
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sourcetargetTypeEffectReferences
6821P12931Q05397NonestimulationAdhesome:10085298;Adhesome:10592173;Adhesome:1...
32968P12931P19022NoneinhibitionACSN:15782139;ACSN:16371504;ACSN:16492141;ACSN...
5154P12931Q14289NonestimulationAdhesome:10329689;Adhesome:10521452;Adhesome:1...
44795Q14289Q05397NonestimulationAdhesome:16760434;HPRD:16760434;KEA:12960434;K...
11582P12931P35222NonestimulationACSN:10593980;ACSN:12123611;ACSN:15782139;ACSN...
..................
67482P00533Q05397NonestimulationACSN:10545505;ACSN:16919435;ACSN:17496910;ACSN...
7631Q14289P00533NonestimulationCA1:11274221;HPRD:10777553;InnateDB:14963038;S...
73973P00533P35222NonestimulationACSN:12040186;ACSN:14585353;ACSN:17496910;ACSN...
2907Q15139P00533NonestimulationCancerCellMap:10523301;CancerCellMap:2984676;C...
78053P00533P56945NoneinhibitionKEA:17570479;ProtMapper:15951569;SPIKE_LC:1714...
\n", + "

71 rows × 5 columns

\n", + "
" + ], + "text/plain": [ + " source target Type Effect \\\n", + "6821 P12931 Q05397 None stimulation \n", + "32968 P12931 P19022 None inhibition \n", + "5154 P12931 Q14289 None stimulation \n", + "44795 Q14289 Q05397 None stimulation \n", + "11582 P12931 P35222 None stimulation \n", + "... ... ... ... ... \n", + "67482 P00533 Q05397 None stimulation \n", + "7631 Q14289 P00533 None stimulation \n", + "73973 P00533 P35222 None stimulation \n", + "2907 Q15139 P00533 None stimulation \n", + "78053 P00533 P56945 None inhibition \n", + "\n", + " References \n", + "6821 Adhesome:10085298;Adhesome:10592173;Adhesome:1... \n", + "32968 ACSN:15782139;ACSN:16371504;ACSN:16492141;ACSN... \n", + "5154 Adhesome:10329689;Adhesome:10521452;Adhesome:1... \n", + "44795 Adhesome:16760434;HPRD:16760434;KEA:12960434;K... \n", + "11582 ACSN:10593980;ACSN:12123611;ACSN:15782139;ACSN... \n", + "... ... \n", + "67482 ACSN:10545505;ACSN:16919435;ACSN:17496910;ACSN... \n", + "7631 CA1:11274221;HPRD:10777553;InnateDB:14963038;S... \n", + "73973 ACSN:12040186;ACSN:14585353;ACSN:17496910;ACSN... \n", + "2907 CancerCellMap:10523301;CancerCellMap:2984676;C... \n", + "78053 KEA:17570479;ProtMapper:15951569;SPIKE_LC:1714... \n", + "\n", + "[71 rows x 5 columns]" + ] + }, + "execution_count": 15, + "metadata": {}, + "output_type": "execute_result" + } + ], + "source": [ + "#We can access to the edges of the network\n", + "new_net1.edges" + ] + }, + { + "cell_type": "code", + "execution_count": 13, + "id": "9540f33d-68f8-4c98-b68e-3e3d1497467e", + "metadata": {}, + "outputs": [ + { + "name": "stdout", + "output_type": "stream", + "text": [ + " Genesymbol in_tissue\n", + "0 SRC True\n", + "1 NOTCH1 True\n", + "2 PTK2 True\n", + "3 CDH1 True\n", + "4 CDH2 True\n", + "5 VIM True\n", + "6 MAP4K4 True\n", + "7 LATS1 True\n", + "8 LATS2 True\n", + "9 PTK2B True\n", + "10 CTNNB1 True\n", + "11 DAB1 True\n", + "12 MET True\n", + "13 PRKD1 True\n", + "14 CTNND1 True\n", + "15 PAK2 True\n", + "16 MAPK8 True\n", + "17 MAP3K7 True\n", + "18 MAP3K1 True\n", + "19 RAF1 True\n", + "20 STK3 True\n", + "21 STK4 True\n", + "22 NF2 True\n", + "23 SMAD3 True\n", + "24 BCAR1 True\n", + "25 LCK True\n", + "26 PTPRH True\n", + "27 WWTR1 True\n", + "28 YAP1 True\n", + "29 RUNX2 True\n", + "30 EGFR True\n" + ] + } + ], + "source": [ + "annot = Ontology()\n", + "#user_defined_tissue = 'breast cancer'\n", + "results_df = annot.check_tissue_annotations(genes_df = new_net1.nodes, tissue = 'colorectal cancer')\n", + "print(results_df)" + ] + }, + { + "cell_type": "code", + "execution_count": 12, + "id": "fbd98405-045a-4316-8174-e96e9a71d9ee", + "metadata": {}, + "outputs": [ + { + "data": { + "image/svg+xml": [ + "\n", + "\n", + "\n", + "\n", + "\n", + "\n", + "%3\n", + "\n", + "\n", + "\n", + "SRC\n", + "\n", + "SRC\n", + "\n", + "\n", + "\n", + "PTK2\n", + "\n", + "PTK2\n", + "\n", + "\n", + "\n", + "SRC->PTK2\n", + "\n", + "\n", + "\n", + "\n", + "\n", + "CDH2\n", + "\n", + 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"output_type": "display_data" + } + ], + "source": [ + "network_visualizer = NetworkVisualizer(new_net1)\n", + "network_visualizer.tissue_mapping(results_df)\n", + "network_visualizer.render()" + ] + }, + { + "cell_type": "code", + "execution_count": 14, + "id": "6762228b-7e6c-4711-a07a-660c77f406e5", + "metadata": {}, + "outputs": [ + { + "data": { + "image/svg+xml": [ + "\n", + "\n", + "\n", + "\n", + "\n", + "\n", + "%3\n", + "\n", + "\n", + "\n", + "CDH1\n", + "\n", + "CDH1\n", + "\n", + "\n", + "\n", + "EGFR\n", + "\n", + "EGFR\n", + "\n", + "\n", + "\n", + "CDH1->EGFR\n", + "\n", + "\n", + "\n", + "\n", + "\n", + "CTNND1\n", + "\n", + "CTNND1\n", + "\n", + "\n", + "\n", + "EGFR->CTNND1\n", + "\n", + "\n", + "\n", + "\n", + "\n", + "\n", + "PTK2\n", + "\n", + "PTK2\n", + "\n", + "\n", + "\n", + "EGFR->PTK2\n", + "\n", + "\n", + "\n", + "\n", + "\n", + "CTNNB1\n", + "\n", + "CTNNB1\n", + "\n", + "\n", + "\n", + "EGFR->CTNNB1\n", + "\n", + "\n", + "\n", + "\n", + "\n", + "BCAR1\n", + "\n", + "BCAR1\n", + "\n", + "\n", + "\n", + "EGFR->BCAR1\n", + "\n", + "\n", + "\n", + "\n", + "\n", + "\n", + "SRC\n", + "\n", + "SRC\n", + "\n", + "\n", + "\n", + "SRC->EGFR\n", + "\n", + "\n", + "\n", + "\n", + "\n", + "PTK2B\n", + "\n", + "PTK2B\n", + "\n", + "\n", + "\n", + "PTK2B->EGFR\n", + "\n", + "\n", + "\n", + "\n", + "\n", + "PRKD1\n", + "\n", + "PRKD1\n", + "\n", + "\n", + "\n", + "PRKD1->EGFR\n", + "\n", + "\n", + "\n", + "\n", + "\n" + ], + "text/plain": [ + "" + ] + }, + "metadata": {}, + "output_type": "display_data" + } + ], + "source": [ + "visualizer = NetworkVisualizer(new_net1, predefined_node=\"EGFR\",color_by='effect')\n", + "visualizer.render()" + ] + }, + { + "cell_type": "markdown", + "id": "57cabbaa", + "metadata": {}, + "source": [ + "### We can access the network object edges to explore which interactions are in our network" + ] + }, + { + "cell_type": "markdown", + "id": "2a250d98", + "metadata": {}, + "source": [ + "# If the all_interaction database of omnipath is not sufficient, we can change it or extend it. To do it, we can use the Resources object:" + ] + }, + { + "cell_type": "code", + "execution_count": 10, + "id": "794f4de1", + "metadata": {}, + "outputs": [], + "source": [ + "interactions = op.interactions.AllInteractions.get() #first we get the interactions from omnipath" + ] + }, + { + "cell_type": "markdown", + "id": "aeec437c", + "metadata": {}, + "source": [ + "### Then, we can add allInteractions in the Resources object" + ] + }, + { + "cell_type": "code", + "execution_count": 11, + "id": "d45b7920", + "metadata": {}, + "outputs": [], + "source": [ + "resources = Resources()\n", + "resources.add_database(interactions)" + ] + }, + { + "cell_type": "code", + "execution_count": 12, + "id": "8dfed589", + "metadata": {}, + "outputs": [ + { + "data": { + "text/html": [ + "
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sourcetargetis_directedis_stimulationis_inhibitionconsensus_directionconsensus_stimulationconsensus_inhibitioncuration_effortreferencessourcestypen_sourcesn_primary_sourcesn_referencesreferences_stripped
0P0DP23P48995TrueFalseTrueTrueFalseTrue3TRIP:11290752;TRIP:11983166;TRIP:12601176TRIPpost_translational11311290752;11983166;12601176
1P0DP25P48995TrueFalseTrueTrueFalseTrue3TRIP:11290752;TRIP:11983166;TRIP:12601176TRIPpost_translational11311290752;11983166;12601176
2P0DP24P48995TrueFalseTrueTrueFalseTrue3TRIP:11290752;TRIP:11983166;TRIP:12601176TRIPpost_translational11311290752;11983166;12601176
3Q03135P48995TrueTrueFalseTrueTrueFalse13DIP:19897728;HPRD:12732636;IntAct:19897728;Lit...DIP;HPRD;IntAct;Lit-BM-17;TRIPpost_translational55810980191;12732636;14551243;16822931;18430726;1...
4P14416P48995TrueTrueFalseTrueTrueFalse1TRIP:18261457TRIPpost_translational11118261457
...................................................
276174439260P35348TrueFalseFalseFalseFalseFalse3Cellinker:10433504;Cellinker:7651358;Cellinker...Cellinker;Guide2Pharma_Cellinkersmall_molecule_protein21310433504;7651358;8564227
2761755202Q13639TrueFalseFalseFalseFalseFalse10Cellinker:10646498;Cellinker:10683202;Cellinke...Cellinker;Guide2Pharma_Cellinkersmall_molecule_protein211010646498;10683202;10821780;11030734;11218067;1...
2761766305Q6DWJ6TrueFalseFalseFalseFalseFalse1Cellinker:26349500Cellinker;Guide2Pharma_Cellinkersmall_molecule_protein21126349500
276177643961Q9GZU1TrueFalseFalseFalseFalseFalse1Cellinker:20802798Cellinker;Guide2Pharma_Cellinkersmall_molecule_protein21120802798
276178448457Q13258TrueFalseFalseFalseFalseFalse4Cellinker:10448933;Cellinker:16604093;Cellinke...Cellinker;Guide2Pharma_Cellinkersmall_molecule_protein21410448933;16604093;7642548;9579725
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276179 rows × 16 columns

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" + ], + "text/plain": [ + " source target is_directed is_stimulation is_inhibition \\\n", + "0 P0DP23 P48995 True False True \n", + "1 P0DP25 P48995 True False True \n", + "2 P0DP24 P48995 True False True \n", + "3 Q03135 P48995 True True False \n", + "4 P14416 P48995 True True False \n", + "... ... ... ... ... ... \n", + "276174 439260 P35348 True False False \n", + "276175 5202 Q13639 True False False \n", + "276176 6305 Q6DWJ6 True False False \n", + "276177 643961 Q9GZU1 True False False \n", + "276178 448457 Q13258 True False False \n", + "\n", + " consensus_direction consensus_stimulation consensus_inhibition \\\n", + "0 True False True \n", + "1 True False True \n", + "2 True False True \n", + "3 True True False \n", + "4 True True False \n", + "... ... ... ... \n", + "276174 False False False \n", + "276175 False False False \n", + "276176 False False False \n", + "276177 False False False \n", + "276178 False False False \n", + "\n", + " curation_effort references \\\n", + "0 3 TRIP:11290752;TRIP:11983166;TRIP:12601176 \n", + "1 3 TRIP:11290752;TRIP:11983166;TRIP:12601176 \n", + "2 3 TRIP:11290752;TRIP:11983166;TRIP:12601176 \n", + "3 13 DIP:19897728;HPRD:12732636;IntAct:19897728;Lit... \n", + "4 1 TRIP:18261457 \n", + "... ... ... \n", + "276174 3 Cellinker:10433504;Cellinker:7651358;Cellinker... \n", + "276175 10 Cellinker:10646498;Cellinker:10683202;Cellinke... \n", + "276176 1 Cellinker:26349500 \n", + "276177 1 Cellinker:20802798 \n", + "276178 4 Cellinker:10448933;Cellinker:16604093;Cellinke... \n", + "\n", + " sources type n_sources \\\n", + "0 TRIP post_translational 1 \n", + "1 TRIP post_translational 1 \n", + "2 TRIP post_translational 1 \n", + "3 DIP;HPRD;IntAct;Lit-BM-17;TRIP post_translational 5 \n", + "4 TRIP post_translational 1 \n", + "... ... ... ... \n", + "276174 Cellinker;Guide2Pharma_Cellinker small_molecule_protein 2 \n", + "276175 Cellinker;Guide2Pharma_Cellinker small_molecule_protein 2 \n", + "276176 Cellinker;Guide2Pharma_Cellinker small_molecule_protein 2 \n", + "276177 Cellinker;Guide2Pharma_Cellinker small_molecule_protein 2 \n", + "276178 Cellinker;Guide2Pharma_Cellinker small_molecule_protein 2 \n", + "\n", + " n_primary_sources n_references \\\n", + "0 1 3 \n", + "1 1 3 \n", + "2 1 3 \n", + "3 5 8 \n", + "4 1 1 \n", + "... ... ... \n", + "276174 1 3 \n", + "276175 1 10 \n", + "276176 1 1 \n", + "276177 1 1 \n", + "276178 1 4 \n", + "\n", + " references_stripped \n", + "0 11290752;11983166;12601176 \n", + "1 11290752;11983166;12601176 \n", + "2 11290752;11983166;12601176 \n", + "3 10980191;12732636;14551243;16822931;18430726;1... \n", + "4 18261457 \n", + "... ... \n", + "276174 10433504;7651358;8564227 \n", + "276175 10646498;10683202;10821780;11030734;11218067;1... \n", + "276176 26349500 \n", + "276177 20802798 \n", + "276178 10448933;16604093;7642548;9579725 \n", + "\n", + "[276179 rows x 16 columns]" + ] + }, + "execution_count": 12, + "metadata": {}, + "output_type": "execute_result" + } + ], + "source": [ + "resources.interactions" + ] + }, + { + "cell_type": "markdown", + "id": "d3dca809", + "metadata": {}, + "source": [ + "### Now we can explore another database we are interested in, for example, the ligand receptor one" + ] + }, + { + "cell_type": "code", + "execution_count": 13, + "id": "829de33a", + "metadata": {}, + "outputs": [], + "source": [ + "extra = op.interactions.LigRecExtra.get()" + ] + }, + { + "cell_type": "markdown", + "id": "fc585a3c", + "metadata": {}, + "source": [ + "### And then we add it to the Resources object" + ] + }, + { + "cell_type": "code", + "execution_count": 14, + "id": "91ae2cef", + "metadata": {}, + "outputs": [], + "source": [ + "resources.add_database(extra, reset_index=True)" + ] + }, + { + "cell_type": "markdown", + "id": "0e6e1986", + "metadata": {}, + "source": [ + "### Now we create the network with a similar list of genes but specifying the Resource object" + ] + }, + { + "cell_type": "code", + "execution_count": 15, + "id": "7401c535", + "metadata": {}, + "outputs": [], + "source": [ + "genes = [\"SRC\", \"NOTCH1\", \"PTK2\", \"CDH1\", \"CDH2\", \"VIM\", \"MAP4K4\", \"PTK2B\", \"COL1A1\"]" + ] + }, + { + "cell_type": "code", + "execution_count": 17, + "id": "60fcff6d", + "metadata": {}, + "outputs": [ + { + "name": "stdout", + "output_type": "stream", + "text": [ + "CPU times: user 22.9 ms, sys: 3.98 ms, total: 26.9 ms\n", + "Wall time: 25.7 ms\n" + ] + } + ], + "source": [ + "%%time\n", + "new_net1 = Network(genes, resources=resources.interactions)" + ] + }, + { + "cell_type": "code", + "execution_count": 18, + "id": "370180cc", + "metadata": {}, + "outputs": [ + { + "name": "stdout", + "output_type": "stream", + "text": [ + "P12931 Q05397\n", + "P12830 P12931\n", + "P12931 P19022\n", + "P12931 Q14289\n", + "P02452 P12931\n", + "P46531 P19022\n", + "P46531 P02452\n", + "Q14289 Q05397\n", + "CPU times: user 1.34 s, sys: 19.9 ms, total: 1.36 s\n", + "Wall time: 1.36 s\n" + ] + } + ], + "source": [ + "%%time\n", + "new_net1.connect_nodes(only_signed=True, consensus_only=True)" + ] + }, + { + "cell_type": "code", + "execution_count": 19, + "id": "8ffecf5c", + "metadata": {}, + "outputs": [ + { + "name": "stdout", + "output_type": "stream", + "text": [ + "looking for paths in the network with length: 0 for node SRC and NOTCH1\n", + "looking for paths in the network with length: 1 for node SRC and NOTCH1\n", + "looking for paths in the network with length: 2 for node SRC and NOTCH1\n", + "Found a path!\n", + "[['SRC', 'COL1A1', 'NOTCH1']]\n", + "looking for paths in the network with length: 0 for node SRC and PTK2\n", + "looking for paths in the network with length: 1 for node SRC and PTK2\n", + "Found a path!\n", + "[['SRC', 'PTK2']]\n", + "looking for paths in the network with length: 0 for node SRC and CDH1\n", + "looking for paths in the network with length: 1 for node SRC and CDH1\n", + "Found a path!\n", + "[['SRC', 'CDH1']]\n", + "looking for paths in the network with length: 0 for node SRC and CDH2\n", + "looking for paths in the network with length: 1 for node SRC and CDH2\n", + "Found a path!\n", + "[['SRC', 'CDH2']]\n", + "looking for paths in the network with length: 0 for node SRC and VIM\n", + "looking for paths in the network with length: 1 for node SRC and VIM\n", + "looking for paths in the network with length: 2 for node SRC and VIM\n", + "looking for paths in the network with length: 3 for node SRC and VIM\n", + "i_search = 3\n", + "Looking for paths with length: 0 for node SRC and VIM\n", + "i_search = 3\n", + "Looking for paths with length: 1 for node SRC and VIM\n", + "i_search = 3\n", + "Looking for paths with length: 2 for node SRC and VIM\n", + "[['SRC', 'TCF7L2', 'VIM'], ['SRC', 'NFKB1', 'VIM'], ['SRC', 'HNF4A', 'VIM'], ['SRC', 'HIPK2', 'VIM'], ['SRC', 'STAT5A', 'VIM']]\n", + "P12931 Q9NQB0\n", + "Q9NQB0 P08670\n", + "P12931 P19838\n", + "P19838 P08670\n", + "P12931 P41235\n", + "P41235 P08670\n", + "P12931 Q9H2X6\n", + "Q9H2X6 P08670\n", + "P12931 P42229\n", + "P42229 P08670\n", + "P12931 Q05397\n", + "P12830 P12931\n", + "P12931 P19022\n", + "P12931 Q14289\n", + "P02452 P12931\n", + "P12931 Q9NQB0\n", + "P12931 P19838\n", + "P12931 P41235\n", + "P41235 P12931\n", + "P12931 Q9H2X6\n", + "P12931 P42229\n", + "P46531 P19022\n", + "P46531 P02452\n", + "P46531 P19838\n", + "Q14289 Q05397\n", + "Q9NQB0 P08670\n", + "P19838 P08670\n", + "P41235 P08670\n", + "Q9H2X6 P08670\n", + "P42229 P08670\n", + "P19838 P02452\n", + "P41235 Q9NQB0\n", + "P19838 P42229\n", + "looking for paths in the network with length: 0 for node SRC and MAP4K4\n", + "looking for paths in the network with length: 1 for node SRC and MAP4K4\n", + "looking for paths in the network with length: 2 for node SRC and MAP4K4\n", + "looking for paths in the network with length: 3 for node SRC and MAP4K4\n", + "i_search = 3\n", + "Looking for paths with length: 0 for node SRC and MAP4K4\n", + "i_search = 3\n", + "Looking for paths with length: 1 for node SRC and MAP4K4\n", + "i_search = 3\n", + "Looking for paths with length: 2 for node SRC and MAP4K4\n", + "[['SRC', 'EPHB1', 'MAP4K4'], ['SRC', 'PPARG', 'MAP4K4']]\n", + "P12931 P54762\n", + "P54762 O95819\n", + "P12931 P37231\n", + "P37231 O95819\n", + "P12931 Q05397\n", + "P12830 P12931\n", + "P12931 P19022\n", + "P12931 Q14289\n", + "P02452 P12931\n", + "P12931 Q9NQB0\n", + "P12931 P19838\n", + "P12931 P41235\n", + "P41235 P12931\n", + "P12931 Q9H2X6\n", + "P12931 P42229\n", + "P12931 P54762\n", + "P54762 P12931\n", + "P12931 P37231\n", + "P46531 P19022\n", + "P46531 P02452\n", + "P46531 P19838\n", + "P46531 P37231\n", + "Q14289 Q05397\n", + "P54762 Q05397\n", + "P37231 P12830\n", + "P37231 P19022\n", + "Q9NQB0 P08670\n", + "P19838 P08670\n", + "P41235 P08670\n", + "Q9H2X6 P08670\n", + "P42229 P08670\n", + "P54762 O95819\n", + "P37231 O95819\n", + "P19838 P02452\n", + "P41235 Q9NQB0\n", + "P19838 P42229\n", + "P37231 P19838\n", + "P37231 P42229\n", + "looking for paths in the network with length: 0 for node SRC and PTK2B\n", + "looking for paths in the network with length: 1 for node SRC and PTK2B\n", + "Found a path!\n", + "[['SRC', 'PTK2B']]\n", + "looking for paths in the network with length: 0 for node SRC and COL1A1\n", + "looking for paths in the network with length: 1 for node SRC and COL1A1\n", + "Found a path!\n", + "[['SRC', 'COL1A1']]\n", + "looking for paths in the network with length: 0 for node NOTCH1 and PTK2\n", + "looking for paths in the network with length: 1 for node NOTCH1 and PTK2\n", + "looking for paths in the network with length: 2 for node NOTCH1 and PTK2\n", + "looking for paths in the network with length: 3 for node NOTCH1 and PTK2\n", + "Found a path!\n", + "[['NOTCH1', 'COL1A1', 'SRC', 'PTK2']]\n", + "looking for paths in the network with length: 0 for node NOTCH1 and CDH1\n", + "looking for paths in the network with length: 1 for node NOTCH1 and CDH1\n", + "looking for paths in the network with length: 2 for node NOTCH1 and CDH1\n", + "Found a path!\n", + "[['NOTCH1', 'PPARG', 'CDH1']]\n", + "looking for paths in the network with length: 0 for node NOTCH1 and CDH2\n", + "looking for paths in the network with length: 1 for node NOTCH1 and CDH2\n", + "Found a path!\n", + "[['NOTCH1', 'CDH2']]\n", + "looking for paths in the network with length: 0 for node NOTCH1 and VIM\n", + "looking for paths in the network with length: 1 for node NOTCH1 and VIM\n", + "looking for paths in the network with length: 2 for node NOTCH1 and VIM\n", + "Found a path!\n", + "[['NOTCH1', 'NFKB1', 'VIM']]\n", + "looking for paths in the network with length: 0 for node NOTCH1 and MAP4K4\n", + "looking for paths in the network with length: 1 for node NOTCH1 and MAP4K4\n", + "looking for paths in the network with length: 2 for node NOTCH1 and MAP4K4\n", + "Found a path!\n", + "[['NOTCH1', 'PPARG', 'MAP4K4']]\n", + "looking for paths in the network with length: 0 for node NOTCH1 and PTK2B\n", + "looking for paths in the network with length: 1 for node NOTCH1 and PTK2B\n", + "looking for paths in the network with length: 2 for node NOTCH1 and PTK2B\n", + "looking for paths in the network with length: 3 for node NOTCH1 and PTK2B\n", + "Found a path!\n", + "[['NOTCH1', 'COL1A1', 'SRC', 'PTK2B']]\n", + "looking for paths in the network with length: 0 for node NOTCH1 and COL1A1\n", + "looking for paths in the network with length: 1 for node NOTCH1 and COL1A1\n", + "Found a path!\n", + "[['NOTCH1', 'COL1A1']]\n", + "looking for paths in the network with length: 0 for node PTK2 and CDH1\n", + "looking for paths in the network with length: 1 for node PTK2 and CDH1\n", + "looking for paths in the network with length: 2 for node PTK2 and CDH1\n", + "Found a path!\n", + "[['PTK2', 'SRC', 'CDH1']]\n", + "looking for paths in the network with length: 0 for node PTK2 and CDH2\n", + "looking for paths in the network with length: 1 for node PTK2 and CDH2\n", + "looking for paths in the network with length: 2 for node PTK2 and CDH2\n", + "looking for paths in the network with length: 3 for node PTK2 and CDH2\n", + "i_search = 3\n", + "Looking for paths with length: 0 for node PTK2 and CDH2\n", + "i_search = 3\n", + "Looking for paths with length: 1 for node PTK2 and CDH2\n", + "i_search = 3\n", + "Looking for paths with length: 2 for node PTK2 and CDH2\n", + "i_search = 3\n", + "Looking for paths with length: 3 for node PTK2 and CDH2\n", + "[['PTK2', 'ZYX', 'SRC', 'CDH2'], ['PTK2', 'STAT1', 'SMAD7', 'CDH2'], ['PTK2', 'STAT1', 'ABL1', 'CDH2'], ['PTK2', 'STAT1', 'JUN', 'CDH2'], ['PTK2', 'STAT1', 'MYC', 'CDH2'], ['PTK2', 'STAT1', 'COMPLEX:P19838_Q04206', 'CDH2'], ['PTK2', 'STAT1', 'WT1', 'CDH2'], ['PTK2', 'STAT1', 'MET', 'CDH2'], ['PTK2', 'ACTN3', 'SRC', 'CDH2'], ['PTK2', 'PIK3CG', 'AR', 'CDH2'], ['PTK2', 'MITF', 'MET', 'CDH2'], ['PTK2', 'MITF', 'PAX6', 'CDH2'], ['PTK2', 'IL6', 'MET', 'CDH2'], ['PTK2', 'CDC42', 'CTNND1', 'CDH2'], ['PTK2', 'ASAP1', 'AR', 'CDH2'], ['PTK2', 'RAP1B', 'CTNND1', 'CDH2'], ['PTK2', 'SMAD4', 'MSX1', 'CDH2'], ['PTK2', 'SMAD4', 'PPARG', 'CDH2'], ['PTK2', 'SMAD4', 'MYC', 'CDH2'], ['PTK2', 'SMAD4', 'SMAD7', 'CDH2'], ['PTK2', 'SMAD4', 'SOX9', 'CDH2'], ['PTK2', 'SMAD4', 'MET', 'CDH2'], ['PTK2', 'SMAD4', 'MMP2', 'CDH2'], ['PTK2', 'ITGB4', 'SRC', 'CDH2'], ['PTK2', 'ACTN4', 'SRC', 'CDH2'], ['PTK2', 'PTPN13', 'SRC', 'CDH2'], ['PTK2', 'PTPN13', 'MET', 'CDH2'], ['PTK2', 'TXN', 'PTPN1', 'CDH2'], ['PTK2', 'MAPK12', 'JUN', 'CDH2'], ['PTK2', 'MAPK12', 'MYC', 'CDH2'], ['PTK2', 'NCOA1', 'SRC', 'CDH2'], ['PTK2', 'NCOA1', 'STAT3', 'CDH2'], ['PTK2', 'NCOA1', 'PAWR', 'CDH2'], ['PTK2', 'NCOA1', 'MMP2', 'CDH2'], ['PTK2', 'ROCK1', 'RAC1', 'CDH2'], ['PTK2', 'ROCK1', 'CTNNB1', 'CDH2'], ['PTK2', 'MYCN', 'CTNNB1', 'CDH2'], ['PTK2', 'CEBPA', 'CTNNB1', 'CDH2'], ['PTK2', 'PIK3CB', 'PIK3R1', 'CDH2'], ['PTK2', 'PIK3CB', 'RHOA', 'CDH2'], ['PTK2', 'CAPN2', 'CTNNB1', 'CDH2'], ['PTK2', 'EPHB2', 'CTNNB1', 'CDH2'], ['PTK2', 'PIK3R5', 'RAC1', 'CDH2'], ['PTK2', 'CASP7', 'CTNNB1', 'CDH2'], ['PTK2', 'CDK5', 'RAC1', 'CDH2'], ['PTK2', 'ECM1', 'RAC1', 'CDH2'], ['PTK2', 'ECM1', 'CTNNB1', 'CDH2'], ['PTK2', 'KDR', 'RAC1', 'CDH2'], ['PTK2', 'SOS1', 'PIK3CA', 'CDH2'], ['PTK2', 'SOS1', 'RHOA', 'CDH2'], ['PTK2', 'VEGFA', 'RAC1', 'CDH2'], ['PTK2', 'VEGFA', 'CTNNB1', 'CDH2'], ['PTK2', 'ITGA4', 'RHOA', 'CDH2'], ['PTK2', 'EGFR', 'CDC42', 'CDH2'], ['PTK2', 'SDC4', 'MMP9', 'CDH2'], ['PTK2', 'PECAM1', 'FER', 'CDH2'], ['PTK2', 'PPARD', 'CTNNB1', 'CDH2'], ['PTK2', 'PIK3CG', 'PIK3R1', 'CDH2'], ['PTK2', 'RPS6KB1', 'PIK3R1', 'CDH2'], ['PTK2', 'PIK3R3', 'RAC1', 'CDH2'], ['PTK2', 'EFNA1', 'CTNNB1', 'CDH2'], ['PTK2', 'CASP3', 'CTNNB1', 'CDH2'], ['PTK2', 'PIK3CD', 'PIK3R1', 'CDH2'], ['PTK2', 'PIK3CD', 'RAC1', 'CDH2'], ['PTK2', 'CXCL12', 'CTNNB1', 'CDH2']]\n", + "Q05397 Q15942\n", + "Q15942 P12931\n", + "P12931 P19022\n", + "Q05397 P42224\n", + "P42224 O15105\n", + "O15105 P19022\n", + "Q05397 P42224\n", + "P42224 P00519\n", + "P00519 P19022\n", + "Q05397 P42224\n", + "P42224 P05412\n", + "P05412 P19022\n", + "Q05397 P42224\n", + "P42224 P01106\n", + "P01106 P19022\n", + "Q05397 P42224\n", + "P42224 COMPLEX:P19838_Q04206\n", + "COMPLEX:P19838_Q04206 P19022\n", + "Q05397 P42224\n", + "P42224 P19544\n", + "P19544 P19022\n", + "Q05397 P42224\n", + "P42224 P08581\n", + "P08581 P19022\n", + "Q05397 Q08043\n", + "Q08043 P12931\n", + "P12931 P19022\n", + "Q05397 P48736\n", + "P48736 P10275\n", + "P10275 P19022\n", + "Q05397 O75030\n", + "O75030 P08581\n", + "P08581 P19022\n", + "Q05397 O75030\n", + "O75030 P26367\n", + "P26367 P19022\n", + "Q05397 P05231\n", + "P05231 P08581\n", + "P08581 P19022\n", + "Q05397 P60953\n", + "P60953 O60716\n", + "O60716 P19022\n", + "Q05397 Q9ULH1\n", + "Q9ULH1 P10275\n", + "P10275 P19022\n", + "Q05397 P61224\n", + "P61224 O60716\n", + "O60716 P19022\n", + "Q05397 Q13485\n", + "Q13485 P28360\n", + "P28360 P19022\n", + "Q05397 Q13485\n", + "Q13485 P37231\n", + "P37231 P19022\n", + "Q05397 Q13485\n", + "Q13485 P01106\n", + "P01106 P19022\n", + "Q05397 Q13485\n", + "Q13485 O15105\n", + "O15105 P19022\n", + "Q05397 Q13485\n", + "Q13485 P48436\n", + "P48436 P19022\n", + "Q05397 Q13485\n", + "Q13485 P08581\n", + "P08581 P19022\n", + "Q05397 Q13485\n", + "Q13485 P08253\n", + "P08253 P19022\n", + "Q05397 P16144\n", + "P16144 P12931\n", + "P12931 P19022\n", + "Q05397 O43707\n", + "O43707 P12931\n", + "P12931 P19022\n", + "Q05397 Q12923\n", + "Q12923 P12931\n", + "P12931 P19022\n", + "Q05397 Q12923\n", + "Q12923 P08581\n", + "P08581 P19022\n", + "Q05397 P10599\n", + "P10599 P18031\n", + "P18031 P19022\n", + "Q05397 P53778\n", + "P53778 P05412\n", + "P05412 P19022\n", + "Q05397 P53778\n", + "P53778 P01106\n", + "P01106 P19022\n", + "Q05397 Q15788\n", + "Q15788 P12931\n", + "P12931 P19022\n", + "Q05397 Q15788\n", + "Q15788 P40763\n", + "P40763 P19022\n", + "Q05397 Q15788\n", + "Q15788 Q96IZ0\n", + "Q96IZ0 P19022\n", + "Q05397 Q15788\n", + "Q15788 P08253\n", + "P08253 P19022\n", + "Q13464 Q05397\n", + "P63000 Q13464\n", + "P19022 P63000\n", + "Q13464 Q05397\n", + "Q13464 P35222\n", + "P19022 P35222\n", + "P04198 Q05397\n", + "P35222 P04198\n", + "P19022 P35222\n", + "P49715 Q05397\n", + "P35222 P49715\n", + "P19022 P35222\n", + "Q05397 P42338\n", + "P27986 P42338\n", + "P19022 P27986\n", + "Q05397 P42338\n", + "P61586 P42338\n", + "P19022 P61586\n", + "P17655 Q05397\n", + "P35222 P17655\n", + "P19022 P35222\n", + "P29323 Q05397\n", + "P35222 P29323\n", + "P19022 P35222\n", + "Q05397 Q8WYR1\n", + "Q8WYR1 P63000\n", + "P19022 P63000\n", + "P55210 Q05397\n", + "P35222 P55210\n", + "P19022 P35222\n", + "Q00535 Q05397\n", + "P63000 Q00535\n", + "P19022 P63000\n", + "Q16610 Q05397\n", + "P63000 Q16610\n", + "P19022 P63000\n", + "Q16610 Q05397\n", + "P35222 Q16610\n", + "P19022 P35222\n", + "P35968 Q05397\n", + "P63000 P35968\n", + "P19022 P63000\n", + "Q07889 Q05397\n", + "Q07889 P42336\n", + "P19022 P42336\n", + "Q07889 Q05397\n", + "P61586 Q07889\n", + "P19022 P61586\n", + "P15692 Q05397\n", + "P15692 P63000\n", + "P19022 P63000\n", + "P15692 Q05397\n", + "P35222 P15692\n", + "P19022 P35222\n", + "P13612 Q05397\n", + "P61586 P13612\n", + "P19022 P61586\n", + "P00533 Q05397\n", + "P60953 P00533\n", + "P19022 P60953\n", + "P31431 Q05397\n", + "P14780 P31431\n", + "P19022 P14780\n", + "P16284 Q05397\n", + "P16591 P16284\n", + "P19022 P16591\n", + "Q03181 Q05397\n", + "P35222 Q03181\n", + "P19022 P35222\n", + "Q05397 P48736\n", + "P27986 P48736\n", + "P19022 P27986\n", + "P23443 Q05397\n", + "P23443 P27986\n", + "P19022 P27986\n", + "Q05397 Q92569\n", + "Q92569 P63000\n", + "P19022 P63000\n", + "P20827 Q05397\n", + "P35222 P20827\n", + "P19022 P35222\n", + "P42574 Q05397\n", + "P42574 P35222\n", + "P19022 P35222\n", + "Q05397 O00329\n", + "P27986 O00329\n", + "P19022 P27986\n", + "Q05397 O00329\n", + "O00329 P63000\n", + "P19022 P63000\n", + "P48061 Q05397\n", + "P35222 P48061\n", + "P19022 P35222\n", + "P12931 Q05397\n", + "P12830 P12931\n", + "P12931 P19022\n", + "P12931 Q14289\n", + "P02452 P12931\n", + "P12931 Q9NQB0\n", + 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"P05231 P15692\n", + "P15692 P05231\n", + "P05231 P14780\n", + "Q03181 P05231\n", + "P05231 P48061\n", + "P60953 O60716\n", + "P61224 P60953\n", + "P60953 P53778\n", + "P60953 P35222\n", + "P35222 P60953\n", + "P04198 P60953\n", + "P60953 P27986\n", + "P27986 P60953\n", + "P29323 P60953\n", + "P35968 P60953\n", + "P42336 P60953\n", + "P15692 P60953\n", + "P60953 P00533\n", + "P60953 P23443\n", + "P48061 P60953\n", + "P61224 O60716\n", + "P18031 O60716\n", + "O60716 P63000\n", + "O60716 P27986\n", + "O60716 P61586\n", + "O60716 P42336\n", + "P00533 O60716\n", + "P16591 O60716\n", + "O60716 P20827\n", + "Q9ULH1 P63000\n", + "Q9ULH1 P61586\n", + "P61224 P63000\n", + "P61224 P35222\n", + "P61224 P27986\n", + "P61224 P61586\n", + "P61224 P42336\n", + "P61224 P13612\n", + "Q13485 P28360\n", + "Q13485 P48436\n", + "Q13485 P08253\n", + "Q15788 Q13485\n", + "Q13485 P04198\n", + "Q00535 Q13485\n", + "Q13485 P15692\n", + "Q13485 P00533\n", + "Q13485 Q03181\n", + "Q13485 P48061\n", + "P35222 P28360\n", + "Q13464 P48436\n", + "P48436 P35222\n", + "P48436 P42336\n", + "P48436 P15692\n", + "Q15788 P08253\n", + "P63000 P08253\n", + "P35222 P08253\n", + "P04198 P08253\n", + "P08253 P00533\n", + "P16144 P42338\n", + "P16144 P27986\n", + "P17655 P16144\n", + "P55210 P16144\n", + "P16144 P42336\n", + "P42574 P16144\n", + "P16144 O00329\n", + "P63000 O43707\n", + "O43707 P27986\n", + "O43707 P61586\n", + "P61586 O43707\n", + "O43707 P42336\n", + "P40763 Q12923\n", + "Q12923 P29323\n", + "P10599 P18031\n", + "P18031 P40763\n", + "P18031 P35222\n", + "P18031 P27986\n", + "P61586 P18031\n", + "P17655 P18031\n", + "P18031 P42336\n", + "P00533 P18031\n", + "P16591 P18031\n", + "P53778 P49715\n", + "Q00535 P53778\n", + "Q15788 P40763\n", + "Q15788 Q96IZ0\n", + "Q15788 P15692\n", + "Q15788 P00533\n", + "P63000 P40763\n", + "P40763 P35222\n", + "P49715 P40763\n", + "P40763 P27986\n", + "P27986 P40763\n", + "Q00535 P40763\n", + "P42336 P40763\n", + "P40763 P15692\n", + "P00533 P40763\n", + "P40763 P14780\n", + "P16591 P40763\n", + "P40763 P42574\n", + "P40763 P48061\n", + "P48061 P40763\n", + "P63000 Q13464\n", + "Q13464 P35222\n", + "P35222 Q13464\n", + "P61586 Q13464\n", + "P42574 Q13464\n", + "P48061 Q13464\n", + "P63000 P35222\n", + "P63000 P42338\n", + "P27986 P63000\n", + "P63000 P61586\n", + "P29323 P63000\n", + "P63000 Q8WYR1\n", + "Q8WYR1 P63000\n", + "P63000 Q00535\n", + "P63000 Q16610\n", + "P63000 P35968\n", + "Q07889 P63000\n", + "P63000 P42336\n", + "P42336 P63000\n", + "P63000 P15692\n", + "P15692 P63000\n", + "P13612 P63000\n", + "P00533 P63000\n", + "P31431 P63000\n", + "P63000 Q92569\n", + "Q92569 P63000\n", + "P20827 P63000\n", + "P63000 O00329\n", + "O00329 P63000\n", + "P48061 P63000\n", + "P35222 P04198\n", + "P35222 P49715\n", + "P35222 P27986\n", + "P35222 P61586\n", + "P35222 P17655\n", + "P35222 P29323\n", + "P35222 P55210\n", + "P35222 Q16610\n", + "P35222 P42336\n", + "P35222 P15692\n", + "P00533 P35222\n", + "P35222 P14780\n", + "P16591 P35222\n", + "P35222 Q03181\n", + "P35222 P20827\n", + "P35222 P42574\n", + "P42574 P35222\n", + "P35222 P48061\n", + "P04198 P00533\n", + "Q03181 P49715\n", + "P27986 P42338\n", + "P61586 P42338\n", + "P35968 P42338\n", + "P42338 Q07889\n", + "P00533 P42338\n", + "Q92569 P42338\n", + "P48061 P42338\n", + "P27986 P61586\n", + "P61586 P27986\n", + "P29323 P27986\n", + "P35968 P27986\n", + "P27986 Q07889\n", + "P15692 P27986\n", + "P00533 P27986\n", + "P27986 P23443\n", + "P23443 P27986\n", + "P27986 O00329\n", + "P48061 P27986\n", + "P17655 P61586\n", + "P61586 Q07889\n", + "P61586 P42336\n", + "P42336 P61586\n", + "P61586 P13612\n", + "P00533 P61586\n", + "P61586 P14780\n", + "P20827 P61586\n", + "P42574 P61586\n", + "P29323 P42336\n", + "P48061 P29323\n", + "P35968 Q8WYR1\n", + "P00533 Q8WYR1\n", + "P48061 Q8WYR1\n", + "P42574 P55210\n", + "P35968 Q07889\n", + "P35968 P42336\n", + "P15692 P35968\n", + "P35968 P16284\n", + "P35968 Q92569\n", + "P35968 O00329\n", + "Q07889 P42336\n", + "P42336 Q07889\n", + "P15692 Q07889\n", + "P00533 Q07889\n", + "Q92569 Q07889\n", + "O00329 Q07889\n", + "P15692 P42336\n", + "P00533 P42336\n", + "P42336 P23443\n", + "Q92569 P42336\n", + "P48061 P42336\n", + "P15692 P00533\n", + "P15692 P14780\n", + "P00533 P14780\n", + "P00533 Q92569\n", + "P00533 O00329\n", + "P14780 P31431\n", + "Q03181 P14780\n", + "P23443 P14780\n", + "P48061 P14780\n", + "P16591 P16284\n", + "P48061 Q92569\n", + "P48061 O00329\n", + "looking for paths in the network with length: 0 for node PTK2 and VIM\n", + "looking for paths in the network with length: 1 for node PTK2 and VIM\n", + "looking for paths in the network with length: 2 for node PTK2 and VIM\n", + "looking for paths in the network with length: 3 for node PTK2 and VIM\n", + "Found a path!\n", + "[['PTK2', 'MAPK12', 'JUN', 'VIM'], ['PTK2', 'PIK3R1', 'STAT3', 'VIM'], ['PTK2', 'PIK3R1', 'NFKB1', 'VIM'], ['PTK2', 'IL6', 'STAT3', 'VIM'], ['PTK2', 'CDC42', 'CTNNB1', 'VIM'], ['PTK2', 'NCOA1', 'STAT5A', 'VIM'], ['PTK2', 'NCOA1', 'STAT3', 'VIM'], ['PTK2', 'NCOA1', 'PAWR', 'VIM'], ['PTK2', 'RAC1', 'ROCK1', 'VIM'], ['PTK2', 'RAC1', 'NFKB1', 'VIM'], ['PTK2', 'RAC1', 'STAT3', 'VIM'], ['PTK2', 'RAC1', 'CTNNB1', 'VIM'], ['PTK2', 'RAP1B', 'CTNNB1', 'VIM'], ['PTK2', 'SMAD4', 'TCF7L2', 'VIM'], ['PTK2', 'PIK3CA', 'STAT3', 'VIM'], ['PTK2', 'PIK3CA', 'NFKB1', 'VIM'], ['PTK2', 'STAT1', 'JUN', 'VIM'], ['PTK2', 'STAT1', 'COMPLEX:P19838_Q04206', 'VIM'], ['PTK2', 'TXN', 'NFKB1', 'VIM']]\n", + "looking for paths in the network with length: 0 for node PTK2 and MAP4K4\n", + "looking for paths in the network with length: 1 for node PTK2 and MAP4K4\n", + "looking for paths in the network with length: 2 for node PTK2 and MAP4K4\n", + "looking for paths in the network with length: 3 for node PTK2 and MAP4K4\n", + "Found a path!\n", + "[['PTK2', 'PTPN13', 'EPHB1', 'MAP4K4'], ['PTK2', 'PTPN13', 'EPHB2', 'MAP4K4'], ['PTK2', 'SMAD4', 'PPARG', 'MAP4K4']]\n", + "looking for paths in the network with length: 0 for node PTK2 and PTK2B\n", + "looking for paths in the network with length: 1 for node PTK2 and PTK2B\n", + "Found a path!\n", + "[['PTK2', 'PTK2B']]\n", + "looking for paths in the network with length: 0 for node PTK2 and COL1A1\n", + "looking for paths in the network with length: 1 for node PTK2 and COL1A1\n", + "looking for paths in the network with length: 2 for node PTK2 and COL1A1\n", + "Found a path!\n", + "[['PTK2', 'RAC1', 'COL1A1'], ['PTK2', 'SMAD4', 'COL1A1'], ['PTK2', 'SRC', 'COL1A1'], ['PTK2', 'CASP7', 'COL1A1'], ['PTK2', 'RHOA', 'COL1A1'], ['PTK2', 'ITGA4', 'COL1A1'], ['PTK2', 'SDC4', 'COL1A1'], ['PTK2', 'ITGB4', 'COL1A1'], ['PTK2', 'CASP3', 'COL1A1'], ['PTK2', 'SOS1', 'COL1A1']]\n", + "looking for paths in the network with length: 0 for node CDH1 and CDH2\n", + "looking for paths in the network with length: 1 for node CDH1 and CDH2\n", + "looking for paths in the network with length: 2 for node CDH1 and CDH2\n", + "Found a path!\n", + "[['CDH1', 'SRC', 'CDH2'], ['CDH1', 'RAC1', 'CDH2'], ['CDH1', 'CDC42', 'CDH2']]\n", + "looking for paths in the network with length: 0 for node CDH1 and VIM\n", + "looking for paths in the network with length: 1 for node CDH1 and VIM\n", + "looking for paths in the network with length: 2 for node CDH1 and VIM\n", + "Found a path!\n", + "[['CDH1', 'CTNNB1', 'VIM']]\n", + "looking for paths in the network with length: 0 for node CDH1 and MAP4K4\n", + "looking for paths in the network with length: 1 for node CDH1 and MAP4K4\n", + "looking for paths in the network with length: 2 for node CDH1 and MAP4K4\n", + "looking for paths in the network with length: 3 for node CDH1 and MAP4K4\n", + "Found a path!\n", + "[['CDH1', 'SRC', 'EPHB1', 'MAP4K4'], ['CDH1', 'SRC', 'PPARG', 'MAP4K4'], ['CDH1', 'CTNNB1', 'EPHB2', 'MAP4K4'], ['CDH1', 'CTNNB1', 'PPARG', 'MAP4K4']]\n", + "looking for paths in the network with length: 0 for node CDH1 and PTK2B\n", + "looking for paths in the network with length: 1 for node CDH1 and PTK2B\n", + "looking for paths in the network with length: 2 for node CDH1 and PTK2B\n", + "Found a path!\n", + "[['CDH1', 'SRC', 'PTK2B'], ['CDH1', 'PIK3CA', 'PTK2B'], ['CDH1', 'RAC1', 'PTK2B']]\n", + "looking for paths in the network with length: 0 for node CDH1 and COL1A1\n", + "looking for paths in the network with length: 1 for node CDH1 and COL1A1\n", + "looking for paths in the network with length: 2 for node CDH1 and COL1A1\n", + "Found a path!\n", + "[['CDH1', 'RAC1', 'COL1A1'], ['CDH1', 'RHOA', 'COL1A1']]\n", + "looking for paths in the network with length: 0 for node CDH2 and VIM\n", + "looking for paths in the network with length: 1 for node CDH2 and VIM\n", + "looking for paths in the network with length: 2 for node CDH2 and VIM\n", + "Found a path!\n", + "[['CDH2', 'CTNNB1', 'VIM']]\n", + "looking for paths in the network with length: 0 for node CDH2 and MAP4K4\n", + "looking for paths in the network with length: 1 for node CDH2 and MAP4K4\n", + "looking for paths in the network with length: 2 for node CDH2 and MAP4K4\n", + "looking for paths in the network with length: 3 for node CDH2 and MAP4K4\n", + "Found a path!\n", + "[['CDH2', 'CTNNB1', 'EPHB2', 'MAP4K4'], ['CDH2', 'CTNNB1', 'PPARG', 'MAP4K4']]\n", + "looking for paths in the network with length: 0 for node CDH2 and PTK2B\n", + "looking for paths in the network with length: 1 for node CDH2 and PTK2B\n", + "looking for paths in the network with length: 2 for node CDH2 and PTK2B\n", + "Found a path!\n", + "[['CDH2', 'PIK3CA', 'PTK2B'], ['CDH2', 'STAT3', 'PTK2B']]\n", + "looking for paths in the network with length: 0 for node CDH2 and COL1A1\n", + "looking for paths in the network with length: 1 for node CDH2 and COL1A1\n", + "looking for paths in the network with length: 2 for node CDH2 and COL1A1\n", + "Found a path!\n", + "[['CDH2', 'RAC1', 'COL1A1'], ['CDH2', 'RHOA', 'COL1A1'], ['CDH2', 'SRC', 'COL1A1']]\n", + "looking for paths in the network with length: 0 for node VIM and MAP4K4\n", + "looking for paths in the network with length: 1 for node VIM and MAP4K4\n", + "looking for paths in the network with length: 2 for node VIM and MAP4K4\n", + "looking for paths in the network with length: 3 for node VIM and MAP4K4\n", + "i_search = 3\n", + "Looking for paths with length: 0 for node VIM and MAP4K4\n", + "i_search = 3\n", + "Looking for paths with length: 1 for node VIM and MAP4K4\n", + "i_search = 3\n", + "Looking for paths with length: 2 for node VIM and MAP4K4\n", + "i_search = 3\n", + "Looking for paths with length: 3 for node VIM and MAP4K4\n", + "[['VIM', 'TGFB1', 'TNF', 'MAP4K4'], ['VIM', 'COMPLEX:P19838_Q04206', 'IKBKB', 'MAP4K4'], ['VIM', 'COMPLEX:P19838_Q04206', 'IKBKE', 'MAP4K4'], ['VIM', 'COMPLEX:P19838_Q04206', 'IKBKG', 'MAP4K4'], ['VIM', 'COMPLEX:P19838_Q04206', 'CHUK', 'MAP4K4'], ['VIM', 'TP63', 'IKBKB', 'MAP4K4'], ['VIM', 'AKT1', 'TNF', 'MAP4K4'], ['VIM', 'COMPLEX:Q04206_Q04864', 'IKBKE', 'MAP4K4'], ['VIM', 'COMPLEX:Q00653_Q01201', 'CHUK', 'MAP4K4'], ['VIM', 'MAPKAPK2', 'TNF', 'MAP4K4'], ['VIM', 'JUN', 'MAP3K3', 'MAP4K4'], ['VIM', 'CASP3', 'TNF', 'MAP4K4'], ['VIM', 'PLK1', 'MAP3K8', 'MAP4K4'], ['VIM', 'IRF6', 'TNF', 'MAP4K4'], ['VIM', 'NFKB1', 'IKBKG', 'MAP4K4'], ['VIM', 'NFKB1', 'MAP3K2', 'MAP4K4'], ['VIM', 'NFKB1', 'IKBKE', 'MAP4K4'], ['VIM', 'NFKB1', 'MAP3K3', 'MAP4K4']]\n", + "P01137 P08670\n", + "P01375 P01137\n", + "P01375 O95819\n", + "COMPLEX:P19838_Q04206 P08670\n", + "O14920 COMPLEX:P19838_Q04206\n", + "O95819 O14920\n", + "COMPLEX:P19838_Q04206 P08670\n", + "COMPLEX:P19838_Q04206 Q14164\n", + "O95819 Q14164\n", + "COMPLEX:P19838_Q04206 P08670\n", + "Q9Y6K9 COMPLEX:P19838_Q04206\n", + "O95819 Q9Y6K9\n", + "COMPLEX:P19838_Q04206 P08670\n", + "O15111 COMPLEX:P19838_Q04206\n", + "O95819 O15111\n", + "Q9H3D4 P08670\n", + "O14920 Q9H3D4\n", + "O95819 O14920\n", + "P31749 P08670\n", + "P01375 P31749\n", + "P01375 O95819\n", + "COMPLEX:Q04206_Q04864 P08670\n", + "COMPLEX:Q04206_Q04864 Q14164\n", + "O95819 Q14164\n", + "COMPLEX:Q00653_Q01201 P08670\n", + "O15111 COMPLEX:Q00653_Q01201\n", + "O95819 O15111\n", + "P49137 P08670\n", + "P01375 P49137\n", + "P01375 O95819\n", + "P05412 P08670\n", + "Q99759 P05412\n", + "O95819 Q99759\n", + "P42574 P08670\n", + "P01375 P42574\n", + "P01375 O95819\n", + "P53350 P08670\n", + "P41279 P53350\n", + "O95819 P41279\n", + "O14896 P08670\n", + "O14896 P01375\n", + "P01375 O95819\n", + "P19838 P08670\n", + "P19838 Q9Y6K9\n", + "O95819 Q9Y6K9\n", + "P19838 P08670\n", + "Q9Y2U5 P19838\n", + "O95819 Q9Y2U5\n", + "P19838 P08670\n", + "Q14164 P19838\n", + "O95819 Q14164\n", + "P19838 P08670\n", + "Q99759 P19838\n", + "O95819 Q99759\n", + "P12931 Q05397\n", + "P12830 P12931\n", + "P12931 P19022\n", + "P12931 Q14289\n", + "P02452 P12931\n", + "P12931 Q9NQB0\n", + "P12931 P19838\n", + "P12931 P41235\n", + "P41235 P12931\n", + "P12931 Q9H2X6\n", + "P12931 P42229\n", + "P12931 P54762\n", + "P54762 P12931\n", + "P12931 P37231\n", + "Q15942 P12931\n", + "P12931 P42224\n", + "P12931 P00519\n", + "P05412 P12931\n", + "COMPLEX:P19838_Q04206 P12931\n", + "P12931 P08581\n", + "Q08043 P12931\n", + "P12931 P10275\n", + "P10275 P12931\n", + "P12931 P60953\n", + "P12931 O60716\n", + "P12931 Q9ULH1\n", + "P12931 P08253\n", + "P12931 P16144\n", + "P16144 P12931\n", + "O43707 P12931\n", + "Q12923 P12931\n", + "P18031 P12931\n", + "Q15788 P12931\n", + "P12931 P40763\n", + "P12931 P63000\n", + "P12931 P35222\n", + "P12931 P42338\n", + "P12931 P61586\n", + "P17655 P12931\n", + "P29323 P12931\n", + "P12931 Q8WYR1\n", + "Q00535 P12931\n", + "P12931 P35968\n", + "P12931 Q07889\n", + "P12931 P42336\n", + "P15692 P12931\n", + "P13612 P12931\n", + "P12931 P00533\n", + "P12931 P14780\n", + "P12931 P16284\n", + "P12931 Q92569\n", + "P12931 P20827\n", + "P12931 O00329\n", + "P12931 O14920\n", + "P12931 O15111\n", + "P12931 P31749\n", + "COMPLEX:Q04206_Q04864 P12931\n", + "COMPLEX:Q00653_Q01201 P12931\n", + "P12931 Q9Y2U5\n", + "P46531 P19022\n", + "P46531 P02452\n", + "P46531 P19838\n", + "P46531 P37231\n", + "P46531 P05412\n", + "P46531 P01106\n", + "COMPLEX:P19838_Q04206 P46531\n", + "P10275 P46531\n", + "P26367 P46531\n", + "P46531 P48436\n", + "P40763 P46531\n", + "P35222 P46531\n", + "P46531 P15692\n", + "P46531 P00533\n", + "P46531 P42574\n", + "P46531 O15111\n", + "Q9H3D4 P46531\n", + "COMPLEX:Q04206_Q04864 P46531\n", + "COMPLEX:Q00653_Q01201 P46531\n", + "Q14289 Q05397\n", + "P54762 Q05397\n", + "Q05397 Q15942\n", + "Q05397 P42224\n", + "COMPLEX:P19838_Q04206 Q05397\n", + "P08581 Q05397\n", + "Q05397 Q08043\n", + "Q05397 P48736\n", + "P48736 Q05397\n", + "Q05397 O75030\n", + "Q05397 P05231\n", + "Q05397 P60953\n", + "Q05397 Q9ULH1\n", + "Q05397 P61224\n", + "Q05397 Q13485\n", + "Q05397 P16144\n", + "P16144 Q05397\n", + "Q05397 O43707\n", + "Q05397 Q12923\n", + "Q05397 P10599\n", + "P18031 Q05397\n", + "Q05397 P53778\n", + "Q05397 Q15788\n", + "Q15788 Q05397\n", + "Q13464 Q05397\n", + "Q05397 P63000\n", + "P04198 Q05397\n", + "P49715 Q05397\n", + "Q05397 P42338\n", + "P42338 Q05397\n", + "Q05397 P27986\n", + "P61586 Q05397\n", + "P17655 Q05397\n", + "P29323 Q05397\n", + "Q05397 Q8WYR1\n", + "Q8WYR1 Q05397\n", + "P55210 Q05397\n", + "Q00535 Q05397\n", + "Q16610 Q05397\n", + "P35968 Q05397\n", + "Q07889 Q05397\n", + "Q05397 P42336\n", + "P15692 Q05397\n", + "P13612 Q05397\n", + "P00533 Q05397\n", + "P31431 Q05397\n", + "P16284 Q05397\n", + "Q03181 Q05397\n", + "P23443 Q05397\n", + "Q05397 Q92569\n", + "Q92569 Q05397\n", + "P20827 Q05397\n", + "P42574 Q05397\n", + "Q05397 O00329\n", + "O00329 Q05397\n", + "P48061 Q05397\n", + "P01375 Q05397\n", + "COMPLEX:Q04206_Q04864 Q05397\n", + "COMPLEX:Q00653_Q01201 Q05397\n", + "P37231 P12830\n", + "P12830 Q15942\n", + "P05412 P12830\n", + "P01106 P12830\n", + "COMPLEX:P19838_Q04206 P12830\n", + "P19544 P12830\n", + "P08581 P12830\n", + "P10275 P12830\n", + "O75030 P12830\n", + "P60953 P12830\n", + "O60716 P12830\n", + "P61224 P12830\n", + "Q13485 P12830\n", + "P12830 P63000\n", + "P63000 P12830\n", + "P12830 P35222\n", + "P12830 P27986\n", + "P12830 P61586\n", + "P12830 P42336\n", + "P12830 P00533\n", + "P12830 P20827\n", + "Q9H3D4 P12830\n", + "COMPLEX:Q04206_Q04864 P12830\n", + "COMPLEX:Q00653_Q01201 P12830\n", + "P37231 P19022\n", + "O15105 P19022\n", + "P00519 P19022\n", + "P05412 P19022\n", + "P01106 P19022\n", + "COMPLEX:P19838_Q04206 P19022\n", + "P19544 P19022\n", + "P08581 P19022\n", + "P10275 P19022\n", + "P26367 P19022\n", + "P19022 P60953\n", + "O60716 P19022\n", + "P28360 P19022\n", + "P48436 P19022\n", + "P08253 P19022\n", + "P18031 P19022\n", + "P40763 P19022\n", + "Q96IZ0 P19022\n", + "P19022 P63000\n", + "P19022 P35222\n", + "P19022 P27986\n", + "P19022 P61586\n", + "Q00535 P19022\n", + "P19022 P42336\n", + "P19022 P14780\n", + "P19022 P16591\n", + "COMPLEX:Q04206_Q04864 P19022\n", + "COMPLEX:Q00653_Q01201 P19022\n", + "Q9NQB0 P08670\n", + "P19838 P08670\n", + "P41235 P08670\n", + "Q9H2X6 P08670\n", + "P42229 P08670\n", + "P05412 P08670\n", + "COMPLEX:P19838_Q04206 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"Q00535 P40763\n", + "P42336 P40763\n", + "P40763 P15692\n", + "P00533 P40763\n", + "P40763 P14780\n", + "P16591 P40763\n", + "P40763 P42574\n", + "P40763 P48061\n", + "P48061 P40763\n", + "P40763 Q14164\n", + "P31749 P40763\n", + "P40763 P53350\n", + "P63000 Q13464\n", + "Q13464 P35222\n", + "P35222 Q13464\n", + "P61586 Q13464\n", + "P42574 Q13464\n", + "P48061 Q13464\n", + "COMPLEX:Q04206_Q04864 Q13464\n", + "COMPLEX:Q00653_Q01201 Q13464\n", + "P63000 P35222\n", + "P63000 P42338\n", + "P27986 P63000\n", + "P63000 P61586\n", + "P29323 P63000\n", + "P63000 Q8WYR1\n", + "Q8WYR1 P63000\n", + "P63000 Q00535\n", + "P63000 Q16610\n", + "P63000 P35968\n", + "Q07889 P63000\n", + "P63000 P42336\n", + "P42336 P63000\n", + "P63000 P15692\n", + "P15692 P63000\n", + "P13612 P63000\n", + "P00533 P63000\n", + "P31431 P63000\n", + "P63000 Q92569\n", + "Q92569 P63000\n", + "P20827 P63000\n", + "P63000 O00329\n", + "O00329 P63000\n", + "P48061 P63000\n", + "P63000 P31749\n", + "P35222 P04198\n", + "P35222 P49715\n", + "P35222 P27986\n", + "P35222 P61586\n", + "P35222 P17655\n", + "P35222 P29323\n", + "P35222 P55210\n", + "P35222 Q16610\n", + "P35222 P42336\n", + "P35222 P15692\n", + "P00533 P35222\n", + "P35222 P14780\n", + "P16591 P35222\n", + "P35222 Q03181\n", + "P35222 P20827\n", + "P35222 P42574\n", + "P42574 P35222\n", + "P35222 P48061\n", + "P35222 Q9Y6K9\n", + "Q9H3D4 P35222\n", + "P35222 P31749\n", + "P31749 P35222\n", + "COMPLEX:Q04206_Q04864 P35222\n", + "COMPLEX:Q00653_Q01201 P35222\n", + "P04198 P00533\n", + "Q03181 P49715\n", + "P49715 P01375\n", + "COMPLEX:Q04206_Q04864 P49715\n", + "COMPLEX:Q00653_Q01201 P49715\n", + "P27986 P42338\n", + "P61586 P42338\n", + "P35968 P42338\n", + "P42338 Q07889\n", + "P00533 P42338\n", + "Q92569 P42338\n", + "P48061 P42338\n", + "P42338 P31749\n", + "P27986 P61586\n", + "P61586 P27986\n", + "P29323 P27986\n", + "P35968 P27986\n", + "P27986 Q07889\n", + "P15692 P27986\n", + "P00533 P27986\n", + "P27986 P23443\n", + "P23443 P27986\n", + "P27986 O00329\n", + "P48061 P27986\n", + "P01137 P27986\n", + "P27986 P31749\n", + "COMPLEX:Q04206_Q04864 P27986\n", + "COMPLEX:Q00653_Q01201 P27986\n", + "P17655 P61586\n", + "P61586 Q07889\n", + "P61586 P42336\n", + "P42336 P61586\n", + "P61586 P13612\n", + "P00533 P61586\n", + "P61586 P14780\n", + "P20827 P61586\n", + "P42574 P61586\n", + "P01375 P61586\n", + "P61586 P31749\n", + "P29323 P42336\n", + "P48061 P29323\n", + "P29323 P01137\n", + "P01137 P29323\n", + "COMPLEX:Q04206_Q04864 P29323\n", + "COMPLEX:Q00653_Q01201 P29323\n", + "P35968 Q8WYR1\n", + "P00533 Q8WYR1\n", + "P48061 Q8WYR1\n", + "Q8WYR1 P31749\n", + "P42574 P55210\n", + "COMPLEX:Q04206_Q04864 P55210\n", + "COMPLEX:Q00653_Q01201 P55210\n", + "P01137 Q16610\n", + "P35968 Q07889\n", + "P35968 P42336\n", + "P15692 P35968\n", + "P35968 P16284\n", + "P35968 Q92569\n", + "P35968 O00329\n", + "P35968 P31749\n", + "COMPLEX:Q04206_Q04864 P35968\n", + "COMPLEX:Q00653_Q01201 P35968\n", + "Q07889 P42336\n", + "P42336 Q07889\n", + "P15692 Q07889\n", + "P00533 Q07889\n", + "Q92569 Q07889\n", + "O00329 Q07889\n", + "Q07889 P31749\n", + "P15692 P42336\n", + "P00533 P42336\n", + "P42336 P23443\n", + "Q92569 P42336\n", + "P48061 P42336\n", + "P01137 P42336\n", + "P42336 P31749\n", + "COMPLEX:Q04206_Q04864 P42336\n", + "COMPLEX:Q00653_Q01201 P42336\n", + "P15692 P00533\n", + "P15692 P14780\n", + "P01137 P15692\n", + "Q9H3D4 P15692\n", + "COMPLEX:Q04206_Q04864 P15692\n", + "COMPLEX:Q00653_Q01201 P15692\n", + "P49137 P15692\n", + "P00533 P14780\n", + "P00533 Q92569\n", + "P00533 O00329\n", + "P01137 P00533\n", + "COMPLEX:Q04206_Q04864 P00533\n", + "COMPLEX:Q00653_Q01201 P00533\n", + "P14780 P31431\n", + "COMPLEX:Q04206_Q04864 P31431\n", + "COMPLEX:Q00653_Q01201 P31431\n", + "Q03181 P14780\n", + "P23443 P14780\n", + "P48061 P14780\n", + "P14780 P01137\n", + "P01375 P14780\n", + "COMPLEX:Q04206_Q04864 P14780\n", + "COMPLEX:Q00653_Q01201 P14780\n", + "P16591 P16284\n", + "COMPLEX:Q04206_Q04864 P16284\n", + "COMPLEX:Q00653_Q01201 P16284\n", + "Q03181 P01137\n", + "P23443 P01137\n", + "P01137 P23443\n", + "P01375 P23443\n", + "P23443 Q9H3D4\n", + "P31749 P23443\n", + "P48061 Q92569\n", + "Q92569 P31749\n", + "P01375 P42574\n", + "P42574 O14920\n", + "P42574 Q9H3D4\n", + "P42574 P31749\n", + "P48061 O00329\n", + "O00329 P31749\n", + "P01137 P48061\n", + "COMPLEX:Q04206_Q04864 P48061\n", + "COMPLEX:Q00653_Q01201 P48061\n", + "P01375 P01137\n", + "P01137 P31749\n", + "P31749 P01137\n", + "COMPLEX:Q04206_Q04864 P01137\n", + "COMPLEX:Q00653_Q01201 P01137\n", + "O14896 P01137\n", + "P01375 O14920\n", + "P01375 Q9Y6K9\n", + "P01375 O15111\n", + "Q9H3D4 P01375\n", + "P01375 P31749\n", + "COMPLEX:Q04206_Q04864 P01375\n", + "COMPLEX:Q00653_Q01201 P01375\n", + "P01375 P49137\n", + "P53350 P01375\n", + "P01375 O14896\n", + "O14896 P01375\n", + "Q9Y6K9 O14920\n", + "O15111 O14920\n", + "O14920 Q9H3D4\n", + "P31749 O14920\n", + "Q99759 O14920\n", + "P53350 O14920\n", + "Q9Y2U5 O14920\n", + "Q14164 COMPLEX:Q04206_Q04864\n", + "COMPLEX:Q04206_Q04864 Q14164\n", + "COMPLEX:Q00653_Q01201 Q14164\n", + "Q9Y6K9 O15111\n", + "P31749 Q9Y6K9\n", + "Q99759 Q9Y6K9\n", + "P41279 Q9Y6K9\n", + "Q9Y2U5 Q9Y6K9\n", + "Q9H3D4 O15111\n", + "P31749 O15111\n", + "O15111 COMPLEX:Q00653_Q01201\n", + "Q99759 O15111\n", + "P41279 O15111\n", + "Q9Y2U5 O15111\n", + "Q9H3D4 P31749\n", + "COMPLEX:Q04206_Q04864 Q9H3D4\n", + "COMPLEX:Q00653_Q01201 Q9H3D4\n", + "P53350 Q9H3D4\n", + "COMPLEX:Q04206_Q04864 P31749\n", + "COMPLEX:Q00653_Q01201 P31749\n", + "P31749 P41279\n", + "COMPLEX:Q04206_Q04864 P53350\n", + "COMPLEX:Q04206_Q04864 P41279\n", + "COMPLEX:Q00653_Q01201 P53350\n", + "COMPLEX:Q00653_Q01201 P41279\n", + "P49137 P53350\n", + "P41279 P53350\n", + "looking for paths in the network with length: 0 for node VIM and PTK2B\n", + "looking for paths in the network with length: 1 for node VIM and PTK2B\n", + "looking for paths in the network with length: 2 for node VIM and PTK2B\n", + "Found a path!\n", + "[['VIM', 'STAT3', 'PTK2B']]\n", + "looking for paths in the network with length: 0 for node VIM and COL1A1\n", + "looking for paths in the network with length: 1 for node VIM and COL1A1\n", + "looking for paths in the network with length: 2 for node VIM and COL1A1\n", + "Found a path!\n", + "[['VIM', 'CASP3', 'COL1A1'], ['VIM', 'CASP7', 'COL1A1']]\n", + "looking for paths in the network with length: 0 for node MAP4K4 and PTK2B\n", + "looking for paths in the network with length: 1 for node MAP4K4 and PTK2B\n", + "looking for paths in the network with length: 2 for node MAP4K4 and PTK2B\n", + "looking for paths in the network with length: 3 for node MAP4K4 and PTK2B\n", + "Found a path!\n", + "[['MAP4K4', 'CHUK', 'MYC', 'PTK2B'], ['MAP4K4', 'TNF', 'PIK3CG', 'PTK2B'], ['MAP4K4', 'TNF', 'TXN', 'PTK2B']]\n", + "looking for paths in the network with length: 0 for node MAP4K4 and COL1A1\n", + "looking for paths in the network with length: 1 for node MAP4K4 and COL1A1\n", + "looking for paths in the network with length: 2 for node MAP4K4 and COL1A1\n", + "looking for paths in the network with length: 3 for node MAP4K4 and COL1A1\n", + "Found a path!\n", + "[['MAP4K4', 'IKBKB', 'NFKB1', 'COL1A1'], ['MAP4K4', 'IKBKG', 'NFKB1', 'COL1A1'], ['MAP4K4', 'MAP3K3', 'NFKB1', 'COL1A1'], ['MAP4K4', 'MAP3K2', 'NFKB1', 'COL1A1'], ['MAP4K4', 'CHUK', 'NFKB1', 'COL1A1'], ['MAP4K4', 'TNF', 'TGFB1', 'COL1A1'], ['MAP4K4', 'TNF', 'NFKB1', 'COL1A1'], ['MAP4K4', 'TNF', 'RHOA', 'COL1A1'], ['MAP4K4', 'IKBKE', 'NFKB1', 'COL1A1'], ['MAP4K4', 'EPHB1', 'SRC', 'COL1A1'], ['MAP4K4', 'PPARG', 'SRC', 'COL1A1']]\n", + "looking for paths in the network with length: 0 for node PTK2B and COL1A1\n", + "looking for paths in the network with length: 1 for node PTK2B and COL1A1\n", + "looking for paths in the network with length: 2 for node PTK2B and COL1A1\n", + "Found a path!\n", + "[['PTK2B', 'RAC1', 'COL1A1'], ['PTK2B', 'SRC', 'COL1A1'], ['PTK2B', 'PIK3CA', 'COL1A1'], ['PTK2B', 'ITGA4', 'COL1A1']]\n", + "CPU times: user 15min 18s, sys: 436 ms, total: 15min 18s\n", + "Wall time: 15min 18s\n" + ] + }, + { + "name": "stdout", + "output_type": "stream", + "text": [ + "P54762 Q05397\n", + "COMPLEX:P05412_P53539 P12830\n", + "COMPLEX:P19838_Q04206 P12830\n", + "COMPLEX:P17535_P53539 P12830\n", + "COMPLEX:Q01201 P12830\n", + "COMPLEX:P15408_P17275 P12830\n", + "COMPLEX:P15407_P17535 P12830\n", + "COMPLEX:P01100_P17275 P12830\n", + "COMPLEX:P19838_Q04864 P12830\n", + "COMPLEX:Q04206 P12830\n", + "COMPLEX:P19838_Q01201 P12830\n", + "COMPLEX:P15407_P17275 P12830\n", + "COMPLEX:P05412_P17275 P12830\n", + "COMPLEX:P17535 P12830\n", + "COMPLEX:Q00653_Q01201 P12830\n", + "COMPLEX:P17275_P53539 P12830\n", + "COMPLEX:P19838_Q00653 P12830\n", + "COMPLEX:P15408_P17535 P12830\n", + "COMPLEX:Q00653_Q04206 P12830\n", + "COMPLEX:P19838 P12830\n", + "COMPLEX:Q04864 P12830\n", + "COMPLEX:P05412_P17535 P12830\n", + "COMPLEX:P01100_P05412 P12830\n", + "COMPLEX:P17275 P12830\n", + "COMPLEX:P05412_P15407 P12830\n", + "COMPLEX:P05412 P12830\n", + "COMPLEX:P01100_P17535 P12830\n", + "COMPLEX:Q04206_Q04864 P12830\n", + "COMPLEX:Q01201_Q04864 P12830\n", + "COMPLEX:Q00653 P12830\n", + "COMPLEX:Q00653_Q04864 P12830\n", + "COMPLEX:Q01201_Q04206 P12830\n", + "COMPLEX:P05412_P15408 P12830\n", + "COMPLEX:P17275_P17535 P12830\n", + "P37231 P12830\n", + "COMPLEX:P05412_P53539 P19022\n", + "COMPLEX:P19838_Q04206 P19022\n", + "COMPLEX:P17535_P53539 P19022\n", + "COMPLEX:Q01201 P19022\n", + "COMPLEX:P15408_P17275 P19022\n", + "COMPLEX:P15407_P17535 P19022\n", + "COMPLEX:P01100_P17275 P19022\n", + "COMPLEX:P19838_Q04864 P19022\n", + "COMPLEX:Q04206 P19022\n", + "COMPLEX:P19838_Q01201 P19022\n", + "COMPLEX:P15407_P17275 P19022\n", + "COMPLEX:P05412_P17275 P19022\n", + "COMPLEX:P17535 P19022\n", + "COMPLEX:Q00653_Q01201 P19022\n", + "COMPLEX:P17275_P53539 P19022\n", + "COMPLEX:P19838_Q00653 P19022\n", + "COMPLEX:P15408_P17535 P19022\n", + "COMPLEX:Q00653_Q04206 P19022\n", + "COMPLEX:P19838 P19022\n", + 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"COMPLEX:P17535 P08670\n", + "Q02447 P08670\n", + "P42229 P08670\n", + "COMPLEX:Q00653_Q01201 P08670\n", + "COMPLEX:P17275_P53539 P08670\n", + "COMPLEX:P19838_Q00653 P08670\n", + "COMPLEX:P15408_P17535 P08670\n", + "COMPLEX:Q00653_Q04206 P08670\n", + "COMPLEX:P19838 P08670\n", + "COMPLEX:Q04864 P08670\n", + "COMPLEX:P05412_P17535 P08670\n", + "P41235 P08670\n", + "COMPLEX:P01100_P05412 P08670\n", + "COMPLEX:P17275 P08670\n", + "COMPLEX:P05412_P15407 P08670\n", + "COMPLEX:P05412 P08670\n", + "COMPLEX:P01100_P17535 P08670\n", + "COMPLEX:Q04206_Q04864 P08670\n", + "Q9H2X6 P08670\n", + "COMPLEX:Q01201_Q04864 P08670\n", + "COMPLEX:Q00653 P08670\n", + "COMPLEX:Q00653_Q04864 P08670\n", + "COMPLEX:Q01201_Q04206 P08670\n", + "COMPLEX:P05412_P15408 P08670\n", + "COMPLEX:P17275_P17535 P08670\n", + "O95819 Q9Y2U5\n", + "P54762 O95819\n", + "P37231 O95819\n", + "COMPLEX:P05412_P53539 Q14289\n", + "COMPLEX:P17535_P53539 Q14289\n", + "COMPLEX:P15408_P17275 Q14289\n", + "COMPLEX:P15407_P17535 Q14289\n", + "COMPLEX:P01100_P17275 Q14289\n", + "COMPLEX:P15407_P17275 Q14289\n", + "COMPLEX:P05412_P17275 Q14289\n", + "COMPLEX:P17535 Q14289\n", + "COMPLEX:P17275_P53539 Q14289\n", + "COMPLEX:P15408_P17535 Q14289\n", + "COMPLEX:P05412_P17535 Q14289\n", + "COMPLEX:P01100_P05412 Q14289\n", + "COMPLEX:P17275 Q14289\n", + "COMPLEX:P05412_P15407 Q14289\n", + "COMPLEX:P05412 Q14289\n", + "COMPLEX:P01100_P17535 Q14289\n", + "COMPLEX:P05412_P15408 Q14289\n", + "COMPLEX:P17275_P17535 Q14289\n", + "P19838 P02452\n", + "P08047 P02452\n", + "Q02447 P02452\n", + "COMPLEX:P05412_P53539 P19838\n", + "COMPLEX:P05412_P53539 P08047\n", + "COMPLEX:P05412_P53539 Q02447\n", + "COMPLEX:P05412_P53539 P37231\n", + "COMPLEX:P19838_Q04206 P19838\n", + "COMPLEX:P19838_Q04206 P08047\n", + "COMPLEX:P19838_Q04206 Q02447\n", + "COMPLEX:P19838_Q04206 P42229\n", + "COMPLEX:P19838_Q04206 P41235\n", + "COMPLEX:P19838_Q04206 P37231\n", + "COMPLEX:P17535_P53539 P19838\n", + "COMPLEX:P17535_P53539 P08047\n", + "COMPLEX:P17535_P53539 Q02447\n", + "COMPLEX:P17535_P53539 P37231\n", + "COMPLEX:Q01201 P19838\n", + "COMPLEX:P15408_P17275 P19838\n", + "COMPLEX:P15407_P17535 P19838\n", + "P08047 P19838\n", + "COMPLEX:P01100_P17275 P19838\n", + "COMPLEX:P19838_Q04864 P19838\n", + "COMPLEX:Q04206 P19838\n", + "COMPLEX:P19838_Q01201 P19838\n", + "COMPLEX:P15407_P17275 P19838\n", + "COMPLEX:P05412_P17275 P19838\n", + "COMPLEX:P17535 P19838\n", + "P19838 P42229\n", + "COMPLEX:Q00653_Q01201 P19838\n", + "COMPLEX:P17275_P53539 P19838\n", + "COMPLEX:P19838_Q00653 P19838\n", + "COMPLEX:P15408_P17535 P19838\n", + "COMPLEX:Q00653_Q04206 P19838\n", + "COMPLEX:P19838 P19838\n", + "COMPLEX:Q04864 P19838\n", + "COMPLEX:P05412_P17535 P19838\n", + "COMPLEX:P01100_P05412 P19838\n", + "COMPLEX:P17275 P19838\n", + "COMPLEX:P05412_P15407 P19838\n", + "COMPLEX:P05412 P19838\n", + "COMPLEX:P01100_P17535 P19838\n", + "COMPLEX:Q04206_Q04864 P19838\n", + "COMPLEX:Q01201_Q04864 P19838\n", + "COMPLEX:Q00653 P19838\n", + "COMPLEX:Q00653_Q04864 P19838\n", + "COMPLEX:Q01201_Q04206 P19838\n", + "COMPLEX:P05412_P15408 P19838\n", + "COMPLEX:P17275_P17535 P19838\n", + "Q9Y2U5 P19838\n", + "P37231 P19838\n", + "P41235 Q9NQB0\n", + "COMPLEX:Q01201 P08047\n", + "COMPLEX:Q01201 Q02447\n", + "COMPLEX:Q01201 P42229\n", + "COMPLEX:Q01201 P41235\n", + "COMPLEX:Q01201 P37231\n", + "COMPLEX:P15408_P17275 P08047\n", + "COMPLEX:P15408_P17275 Q02447\n", + "COMPLEX:P15408_P17275 P37231\n", + "COMPLEX:P15407_P17535 P08047\n", + "COMPLEX:P15407_P17535 Q02447\n", + "COMPLEX:P15407_P17535 P37231\n", + "COMPLEX:P01100_P17275 P08047\n", + "COMPLEX:P19838_Q04864 P08047\n", + "COMPLEX:Q04206 P08047\n", + "COMPLEX:P19838_Q01201 P08047\n", + "COMPLEX:P15407_P17275 P08047\n", + "COMPLEX:P05412_P17275 P08047\n", + "COMPLEX:P17535 P08047\n", + "Q02447 P08047\n", + "COMPLEX:Q00653_Q01201 P08047\n", + "COMPLEX:P17275_P53539 P08047\n", + "COMPLEX:P19838_Q00653 P08047\n", + "COMPLEX:P15408_P17535 P08047\n", + "COMPLEX:Q00653_Q04206 P08047\n", + "COMPLEX:P19838 P08047\n", + "COMPLEX:Q04864 P08047\n", + "COMPLEX:P05412_P17535 P08047\n", + "P08047 P41235\n", + "COMPLEX:P01100_P05412 P08047\n", + "COMPLEX:P17275 P08047\n", + "COMPLEX:P05412_P15407 P08047\n", + "COMPLEX:P05412 P08047\n", + "COMPLEX:P01100_P17535 P08047\n", + "COMPLEX:Q04206_Q04864 P08047\n", + "COMPLEX:Q01201_Q04864 P08047\n", + "COMPLEX:Q00653 P08047\n", + "COMPLEX:Q00653_Q04864 P08047\n", + "COMPLEX:Q01201_Q04206 P08047\n", + "COMPLEX:P05412_P15408 P08047\n", + "COMPLEX:P17275_P17535 P08047\n", + "P08047 P54762\n", + "P37231 P08047\n", + "COMPLEX:P01100_P17275 Q02447\n", + "COMPLEX:P01100_P17275 P37231\n", + "COMPLEX:P19838_Q04864 Q02447\n", + "COMPLEX:P19838_Q04864 P42229\n", + "COMPLEX:P19838_Q04864 P41235\n", + "COMPLEX:P19838_Q04864 P37231\n", + "COMPLEX:Q04206 Q02447\n", + "COMPLEX:Q04206 P42229\n", + "COMPLEX:Q04206 P41235\n", + "COMPLEX:Q04206 P37231\n", + "COMPLEX:P19838_Q01201 Q02447\n", + "COMPLEX:P19838_Q01201 P42229\n", + "COMPLEX:P19838_Q01201 P41235\n", + "COMPLEX:P19838_Q01201 P37231\n", + "COMPLEX:P15407_P17275 Q02447\n", + "COMPLEX:P15407_P17275 P37231\n", + "COMPLEX:P05412_P17275 Q02447\n", + "COMPLEX:P05412_P17275 P37231\n", + "COMPLEX:P17535 Q02447\n", + "COMPLEX:P17535 P37231\n", + "COMPLEX:Q00653_Q01201 Q02447\n", + "COMPLEX:P17275_P53539 Q02447\n", + "COMPLEX:P19838_Q00653 Q02447\n", + "COMPLEX:P15408_P17535 Q02447\n", + "COMPLEX:Q00653_Q04206 Q02447\n", + "COMPLEX:P19838 Q02447\n", + "COMPLEX:Q04864 Q02447\n", + "COMPLEX:P05412_P17535 Q02447\n", + "COMPLEX:P01100_P05412 Q02447\n", + "COMPLEX:P17275 Q02447\n", + "COMPLEX:P05412_P15407 Q02447\n", + "COMPLEX:P05412 Q02447\n", + "COMPLEX:P01100_P17535 Q02447\n", + "COMPLEX:Q04206_Q04864 Q02447\n", + "COMPLEX:Q01201_Q04864 Q02447\n", + "COMPLEX:Q00653 Q02447\n", + "COMPLEX:Q00653_Q04864 Q02447\n", + "COMPLEX:Q01201_Q04206 Q02447\n", + "COMPLEX:P05412_P15408 Q02447\n", + "COMPLEX:P17275_P17535 Q02447\n", + "COMPLEX:Q00653_Q01201 P42229\n", + "COMPLEX:P19838_Q00653 P42229\n", + "COMPLEX:Q00653_Q04206 P42229\n", + "COMPLEX:P19838 P42229\n", + "COMPLEX:Q04864 P42229\n", + "COMPLEX:Q04206_Q04864 P42229\n", + "COMPLEX:Q01201_Q04864 P42229\n", + "COMPLEX:Q00653 P42229\n", + "COMPLEX:Q00653_Q04864 P42229\n", + "COMPLEX:Q01201_Q04206 P42229\n", + "P37231 P42229\n", + "COMPLEX:Q00653_Q01201 P41235\n", + "COMPLEX:Q00653_Q01201 P37231\n", + "COMPLEX:P17275_P53539 P37231\n", + "COMPLEX:P19838_Q00653 P41235\n", + "COMPLEX:P19838_Q00653 P37231\n", + "COMPLEX:P15408_P17535 P37231\n", + "COMPLEX:Q00653_Q04206 P41235\n", + "COMPLEX:Q00653_Q04206 P37231\n", + "COMPLEX:P19838 P41235\n", + "COMPLEX:P19838 P37231\n", + "COMPLEX:Q04864 P41235\n", + "COMPLEX:Q04864 P37231\n", + "COMPLEX:P05412_P17535 P37231\n", + "COMPLEX:Q04206_Q04864 P41235\n", + "COMPLEX:Q01201_Q04864 P41235\n", + "COMPLEX:Q00653 P41235\n", + "COMPLEX:Q00653_Q04864 P41235\n", + "COMPLEX:Q01201_Q04206 P41235\n", + "COMPLEX:P01100_P05412 P37231\n", + "COMPLEX:P17275 P37231\n", + "COMPLEX:P05412_P15407 P37231\n", + "COMPLEX:P05412 P37231\n", + "COMPLEX:P01100_P17535 P37231\n", + "COMPLEX:Q04206_Q04864 P37231\n", + "COMPLEX:Q01201_Q04864 P37231\n", + "COMPLEX:Q00653 P37231\n", + "COMPLEX:Q00653_Q04864 P37231\n", + "COMPLEX:Q01201_Q04206 P37231\n", + "COMPLEX:P05412_P15408 P37231\n", + "COMPLEX:P17275_P17535 P37231\n", + "looking for paths in the network with length: 0 for node SRC and PTK2B\n", + "looking for paths in the network with length: 1 for node SRC and PTK2B\n", + "Found a path!\n", + "[['SRC', 'PTK2B']]\n", + "looking for paths in the network with length: 0 for node SRC and COL1A1\n", + "looking for paths in the network with length: 1 for node SRC and COL1A1\n", + "Found a path!\n", + "[['SRC', 'COL1A1']]\n", + "looking for paths in the network with length: 0 for node NOTCH1 and PTK2\n", + "looking for paths in the network with length: 1 for node NOTCH1 and PTK2\n", + "looking for paths in the network with length: 2 for node NOTCH1 and PTK2\n", + "Found a path!\n", + "[['NOTCH1', 'RELB', 'PTK2'], ['NOTCH1', 'COMPLEX:P19838_Q04864', 'PTK2'], ['NOTCH1', 'COMPLEX:Q00653_Q01201', 'PTK2'], ['NOTCH1', 'RELA', 'PTK2'], ['NOTCH1', 'NFKB1', 'PTK2'], ['NOTCH1', 'COMPLEX:Q00653_Q04206', 'PTK2'], ['NOTCH1', 'COMPLEX:P19838_Q04206', 'PTK2'], ['NOTCH1', 'COMPLEX:P19838_Q01201', 'PTK2'], ['NOTCH1', 'COMPLEX:Q04206_Q04864', 'PTK2'], ['NOTCH1', 'COMPLEX:P19838_Q00653', 'PTK2'], ['NOTCH1', 'REL', 'PTK2'], ['NOTCH1', 'COMPLEX:Q01201_Q04206', 'PTK2'], ['NOTCH1', 'COMPLEX:Q01201_Q04864', 'PTK2'], ['NOTCH1', 'NFKB2', 'PTK2'], ['NOTCH1', 'COMPLEX:Q00653_Q04864', 'PTK2']]\n", + "looking for paths in the network with length: 0 for node NOTCH1 and CDH1\n", + "looking for paths in the network with length: 1 for node NOTCH1 and CDH1\n", + "looking for paths in the network with length: 2 for node NOTCH1 and CDH1\n", + "Found a path!\n", + "[['NOTCH1', 'RELB', 'CDH1'], ['NOTCH1', 'COMPLEX:P19838_Q04864', 'CDH1'], ['NOTCH1', 'COMPLEX:Q00653_Q01201', 'CDH1'], ['NOTCH1', 'RELA', 'CDH1'], ['NOTCH1', 'PPARG', 'CDH1'], ['NOTCH1', 'NFKB1', 'CDH1'], ['NOTCH1', 'COMPLEX:Q00653_Q04206', 'CDH1'], ['NOTCH1', 'COMPLEX:P19838_Q04206', 'CDH1'], ['NOTCH1', 'COMPLEX:P19838_Q01201', 'CDH1'], ['NOTCH1', 'COMPLEX:Q04206_Q04864', 'CDH1'], ['NOTCH1', 'COMPLEX:P19838_Q00653', 'CDH1'], ['NOTCH1', 'REL', 'CDH1'], ['NOTCH1', 'COMPLEX:Q01201_Q04206', 'CDH1'], ['NOTCH1', 'COMPLEX:Q01201_Q04864', 'CDH1'], ['NOTCH1', 'NFKB2', 'CDH1'], ['NOTCH1', 'COMPLEX:Q00653_Q04864', 'CDH1']]\n", + "looking for paths in the network with length: 0 for node NOTCH1 and CDH2\n", + "looking for paths in the network with length: 1 for node NOTCH1 and CDH2\n", + "Found a path!\n", + "[['NOTCH1', 'CDH2']]\n", + "looking for paths in the network with length: 0 for node NOTCH1 and VIM\n", + "looking for paths in the network with length: 1 for node NOTCH1 and VIM\n", + "looking for paths in the network with length: 2 for node NOTCH1 and VIM\n", + "Found a path!\n", + "[['NOTCH1', 'RELB', 'VIM'], ['NOTCH1', 'SP3', 'VIM'], ['NOTCH1', 'COMPLEX:P19838_Q04864', 'VIM'], ['NOTCH1', 'COMPLEX:Q00653_Q01201', 'VIM'], ['NOTCH1', 'RELA', 'VIM'], ['NOTCH1', 'NFKB1', 'VIM'], ['NOTCH1', 'SP1', 'VIM'], ['NOTCH1', 'COMPLEX:Q00653_Q04206', 'VIM'], ['NOTCH1', 'COMPLEX:P19838_Q04206', 'VIM'], ['NOTCH1', 'COMPLEX:P19838_Q01201', 'VIM'], ['NOTCH1', 'COMPLEX:Q04206_Q04864', 'VIM'], ['NOTCH1', 'COMPLEX:P19838_Q00653', 'VIM'], ['NOTCH1', 'REL', 'VIM'], ['NOTCH1', 'NFKB1', 'VIM'], ['NOTCH1', 'COMPLEX:Q01201_Q04206', 'VIM'], ['NOTCH1', 'COMPLEX:Q01201_Q04864', 'VIM'], ['NOTCH1', 'NFKB2', 'VIM'], ['NOTCH1', 'COMPLEX:Q00653_Q04864', 'VIM']]\n", + "looking for paths in the network with length: 0 for node NOTCH1 and MAP4K4\n", + "looking for paths in the network with length: 1 for node NOTCH1 and MAP4K4\n", + "looking for paths in the network with length: 2 for node NOTCH1 and MAP4K4\n", + "Found a path!\n", + "[['NOTCH1', 'PPARG', 'MAP4K4']]\n", + "looking for paths in the network with length: 0 for node NOTCH1 and PTK2B\n", + "looking for paths in the network with length: 1 for node NOTCH1 and PTK2B\n", + "looking for paths in the network with length: 2 for node NOTCH1 and PTK2B\n", + "looking for paths in the network with length: 3 for node NOTCH1 and PTK2B\n" + ] + }, + { + "name": "stdout", + "output_type": "stream", + "text": [ + "Found a path!\n", + "[['NOTCH1', 'RELB', 'SRC', 'PTK2B'], ['NOTCH1', 'RELB', 'PTK2', 'PTK2B'], ['NOTCH1', 'SP3', 'COMPLEX:P15407_P17275', 'PTK2B'], ['NOTCH1', 'SP3', 'COMPLEX:P05412_P53539', 'PTK2B'], ['NOTCH1', 'SP3', 'COMPLEX:P05412_P17535', 'PTK2B'], ['NOTCH1', 'SP3', 'COMPLEX:P17275_P53539', 'PTK2B'], ['NOTCH1', 'SP3', 'COMPLEX:P05412_P15407', 'PTK2B'], ['NOTCH1', 'SP3', 'COMPLEX:P05412_P17275', 'PTK2B'], ['NOTCH1', 'SP3', 'COMPLEX:P01100_P17275', 'PTK2B'], ['NOTCH1', 'SP3', 'JUND', 'PTK2B'], ['NOTCH1', 'SP3', 'COMPLEX:P05412_P15408', 'PTK2B'], ['NOTCH1', 'SP3', 'COMPLEX:P01100_P05412', 'PTK2B'], ['NOTCH1', 'SP3', 'COMPLEX:P17535_P53539', 'PTK2B'], ['NOTCH1', 'SP3', 'SRC', 'PTK2B'], ['NOTCH1', 'SP3', 'COMPLEX:P15408_P17535', 'PTK2B'], ['NOTCH1', 'SP3', 'JUN', 'PTK2B'], ['NOTCH1', 'SP3', 'JUNB', 'PTK2B'], ['NOTCH1', 'SP3', 'COMPLEX:P15408_P17275', 'PTK2B'], ['NOTCH1', 'SP3', 'COMPLEX:P01100_P17535', 'PTK2B'], ['NOTCH1', 'SP3', 'COMPLEX:P15407_P17535', 'PTK2B'], ['NOTCH1', 'SP3', 'COMPLEX:P17275_P17535', 'PTK2B'], ['NOTCH1', 'COL1A1', 'SRC', 'PTK2B'], ['NOTCH1', 'COMPLEX:P19838_Q04864', 'SRC', 'PTK2B'], ['NOTCH1', 'COMPLEX:P19838_Q04864', 'PTK2', 'PTK2B'], ['NOTCH1', 'COMPLEX:Q00653_Q01201', 'SRC', 'PTK2B'], ['NOTCH1', 'COMPLEX:Q00653_Q01201', 'PTK2', 'PTK2B'], ['NOTCH1', 'CDH2', 'COMPLEX:P15407_P17275', 'PTK2B'], ['NOTCH1', 'CDH2', 'COMPLEX:P05412_P53539', 'PTK2B'], ['NOTCH1', 'CDH2', 'COMPLEX:P05412_P17535', 'PTK2B'], ['NOTCH1', 'CDH2', 'COMPLEX:P17275_P53539', 'PTK2B'], ['NOTCH1', 'CDH2', 'COMPLEX:P05412_P15407', 'PTK2B'], ['NOTCH1', 'CDH2', 'COMPLEX:P05412_P17275', 'PTK2B'], ['NOTCH1', 'CDH2', 'COMPLEX:P01100_P17275', 'PTK2B'], ['NOTCH1', 'CDH2', 'JUND', 'PTK2B'], ['NOTCH1', 'CDH2', 'COMPLEX:P05412_P15408', 'PTK2B'], ['NOTCH1', 'CDH2', 'COMPLEX:P01100_P05412', 'PTK2B'], ['NOTCH1', 'CDH2', 'COMPLEX:P17535_P53539', 'PTK2B'], ['NOTCH1', 'CDH2', 'SRC', 'PTK2B'], ['NOTCH1', 'CDH2', 'COMPLEX:P15408_P17535', 'PTK2B'], ['NOTCH1', 'CDH2', 'JUN', 'PTK2B'], ['NOTCH1', 'CDH2', 'JUNB', 'PTK2B'], ['NOTCH1', 'CDH2', 'COMPLEX:P15408_P17275', 'PTK2B'], ['NOTCH1', 'CDH2', 'COMPLEX:P01100_P17535', 'PTK2B'], ['NOTCH1', 'CDH2', 'COMPLEX:P15407_P17535', 'PTK2B'], ['NOTCH1', 'CDH2', 'COMPLEX:P17275_P17535', 'PTK2B'], ['NOTCH1', 'RELA', 'SRC', 'PTK2B'], ['NOTCH1', 'RELA', 'PTK2', 'PTK2B'], ['NOTCH1', 'PPARG', 'COMPLEX:P15407_P17275', 'PTK2B'], ['NOTCH1', 'PPARG', 'COMPLEX:P05412_P53539', 'PTK2B'], ['NOTCH1', 'PPARG', 'COMPLEX:P05412_P17535', 'PTK2B'], ['NOTCH1', 'PPARG', 'COMPLEX:P17275_P53539', 'PTK2B'], ['NOTCH1', 'PPARG', 'COMPLEX:P05412_P15407', 'PTK2B'], ['NOTCH1', 'PPARG', 'COMPLEX:P05412_P17275', 'PTK2B'], ['NOTCH1', 'PPARG', 'COMPLEX:P01100_P17275', 'PTK2B'], ['NOTCH1', 'PPARG', 'JUND', 'PTK2B'], ['NOTCH1', 'PPARG', 'COMPLEX:P05412_P15408', 'PTK2B'], ['NOTCH1', 'PPARG', 'COMPLEX:P01100_P05412', 'PTK2B'], ['NOTCH1', 'PPARG', 'COMPLEX:P17535_P53539', 'PTK2B'], ['NOTCH1', 'PPARG', 'SRC', 'PTK2B'], ['NOTCH1', 'PPARG', 'COMPLEX:P15408_P17535', 'PTK2B'], ['NOTCH1', 'PPARG', 'JUN', 'PTK2B'], ['NOTCH1', 'PPARG', 'JUNB', 'PTK2B'], ['NOTCH1', 'PPARG', 'COMPLEX:P15408_P17275', 'PTK2B'], ['NOTCH1', 'PPARG', 'COMPLEX:P01100_P17535', 'PTK2B'], ['NOTCH1', 'PPARG', 'COMPLEX:P15407_P17535', 'PTK2B'], ['NOTCH1', 'PPARG', 'COMPLEX:P17275_P17535', 'PTK2B'], ['NOTCH1', 'NFKB1', 'SRC', 'PTK2B'], ['NOTCH1', 'NFKB1', 'PTK2', 'PTK2B'], ['NOTCH1', 'SP1', 'COMPLEX:P15407_P17275', 'PTK2B'], ['NOTCH1', 'SP1', 'COMPLEX:P05412_P53539', 'PTK2B'], ['NOTCH1', 'SP1', 'COMPLEX:P05412_P17535', 'PTK2B'], ['NOTCH1', 'SP1', 'COMPLEX:P17275_P53539', 'PTK2B'], ['NOTCH1', 'SP1', 'COMPLEX:P05412_P15407', 'PTK2B'], ['NOTCH1', 'SP1', 'COMPLEX:P05412_P17275', 'PTK2B'], ['NOTCH1', 'SP1', 'COMPLEX:P01100_P17275', 'PTK2B'], ['NOTCH1', 'SP1', 'JUND', 'PTK2B'], ['NOTCH1', 'SP1', 'COMPLEX:P05412_P15408', 'PTK2B'], ['NOTCH1', 'SP1', 'COMPLEX:P01100_P05412', 'PTK2B'], ['NOTCH1', 'SP1', 'COMPLEX:P17535_P53539', 'PTK2B'], ['NOTCH1', 'SP1', 'SRC', 'PTK2B'], ['NOTCH1', 'SP1', 'COMPLEX:P15408_P17535', 'PTK2B'], ['NOTCH1', 'SP1', 'JUN', 'PTK2B'], ['NOTCH1', 'SP1', 'JUNB', 'PTK2B'], ['NOTCH1', 'SP1', 'COMPLEX:P15408_P17275', 'PTK2B'], ['NOTCH1', 'SP1', 'COMPLEX:P01100_P17535', 'PTK2B'], ['NOTCH1', 'SP1', 'COMPLEX:P15407_P17535', 'PTK2B'], ['NOTCH1', 'SP1', 'COMPLEX:P17275_P17535', 'PTK2B'], ['NOTCH1', 'COMPLEX:Q00653_Q04206', 'SRC', 'PTK2B'], ['NOTCH1', 'COMPLEX:Q00653_Q04206', 'PTK2', 'PTK2B'], ['NOTCH1', 'COMPLEX:P19838_Q04206', 'SRC', 'PTK2B'], ['NOTCH1', 'COMPLEX:P19838_Q04206', 'PTK2', 'PTK2B'], ['NOTCH1', 'COMPLEX:P19838_Q01201', 'SRC', 'PTK2B'], ['NOTCH1', 'COMPLEX:P19838_Q01201', 'PTK2', 'PTK2B'], ['NOTCH1', 'COMPLEX:Q04206_Q04864', 'SRC', 'PTK2B'], ['NOTCH1', 'COMPLEX:Q04206_Q04864', 'PTK2', 'PTK2B'], ['NOTCH1', 'COMPLEX:P19838_Q00653', 'SRC', 'PTK2B'], ['NOTCH1', 'COMPLEX:P19838_Q00653', 'PTK2', 'PTK2B'], ['NOTCH1', 'REL', 'SRC', 'PTK2B'], ['NOTCH1', 'REL', 'PTK2', 'PTK2B'], ['NOTCH1', 'NFKB1', 'COMPLEX:P15407_P17275', 'PTK2B'], ['NOTCH1', 'NFKB1', 'COMPLEX:P05412_P53539', 'PTK2B'], ['NOTCH1', 'NFKB1', 'COMPLEX:P05412_P17535', 'PTK2B'], ['NOTCH1', 'NFKB1', 'COMPLEX:P17275_P53539', 'PTK2B'], ['NOTCH1', 'NFKB1', 'COMPLEX:P05412_P15407', 'PTK2B'], ['NOTCH1', 'NFKB1', 'COMPLEX:P05412_P17275', 'PTK2B'], ['NOTCH1', 'NFKB1', 'COMPLEX:P01100_P17275', 'PTK2B'], ['NOTCH1', 'NFKB1', 'JUND', 'PTK2B'], ['NOTCH1', 'NFKB1', 'COMPLEX:P05412_P15408', 'PTK2B'], ['NOTCH1', 'NFKB1', 'COMPLEX:P01100_P05412', 'PTK2B'], ['NOTCH1', 'NFKB1', 'COMPLEX:P17535_P53539', 'PTK2B'], ['NOTCH1', 'NFKB1', 'SRC', 'PTK2B'], ['NOTCH1', 'NFKB1', 'COMPLEX:P15408_P17535', 'PTK2B'], ['NOTCH1', 'NFKB1', 'JUN', 'PTK2B'], ['NOTCH1', 'NFKB1', 'JUNB', 'PTK2B'], ['NOTCH1', 'NFKB1', 'COMPLEX:P15408_P17275', 'PTK2B'], ['NOTCH1', 'NFKB1', 'COMPLEX:P01100_P17535', 'PTK2B'], ['NOTCH1', 'NFKB1', 'COMPLEX:P15407_P17535', 'PTK2B'], ['NOTCH1', 'NFKB1', 'COMPLEX:P17275_P17535', 'PTK2B'], ['NOTCH1', 'COMPLEX:Q01201_Q04206', 'SRC', 'PTK2B'], ['NOTCH1', 'COMPLEX:Q01201_Q04206', 'PTK2', 'PTK2B'], ['NOTCH1', 'COMPLEX:Q01201_Q04864', 'SRC', 'PTK2B'], ['NOTCH1', 'COMPLEX:Q01201_Q04864', 'PTK2', 'PTK2B'], ['NOTCH1', 'NFKB2', 'SRC', 'PTK2B'], ['NOTCH1', 'NFKB2', 'PTK2', 'PTK2B'], ['NOTCH1', 'COMPLEX:Q00653_Q04864', 'SRC', 'PTK2B'], ['NOTCH1', 'COMPLEX:Q00653_Q04864', 'PTK2', 'PTK2B']]\n", + "looking for paths in the network with length: 0 for node NOTCH1 and COL1A1\n", + "looking for paths in the network with length: 1 for node NOTCH1 and COL1A1\n", + "Found a path!\n", + "[['NOTCH1', 'COL1A1']]\n", + "looking for paths in the network with length: 0 for node PTK2 and CDH1\n", + "looking for paths in the network with length: 1 for node PTK2 and CDH1\n", + "looking for paths in the network with length: 2 for node PTK2 and CDH1\n", + "Found a path!\n", + "[['PTK2', 'RELB', 'CDH1'], ['PTK2', 'COMPLEX:P19838_Q04864', 'CDH1'], ['PTK2', 'COMPLEX:Q00653_Q01201', 'CDH1'], ['PTK2', 'SRC', 'CDH1'], ['PTK2', 'RELA', 'CDH1'], ['PTK2', 'NFKB1', 'CDH1'], ['PTK2', 'COMPLEX:Q00653_Q04206', 'CDH1'], ['PTK2', 'COMPLEX:P19838_Q04206', 'CDH1'], ['PTK2', 'COMPLEX:P19838_Q01201', 'CDH1'], ['PTK2', 'COMPLEX:Q04206_Q04864', 'CDH1'], ['PTK2', 'COMPLEX:P19838_Q00653', 'CDH1'], ['PTK2', 'REL', 'CDH1'], ['PTK2', 'COMPLEX:Q01201_Q04206', 'CDH1'], ['PTK2', 'COMPLEX:Q01201_Q04864', 'CDH1'], ['PTK2', 'NFKB2', 'CDH1'], ['PTK2', 'COMPLEX:Q00653_Q04864', 'CDH1']]\n", + "looking for paths in the network with length: 0 for node PTK2 and CDH2\n", + "looking for paths in the network with length: 1 for node PTK2 and CDH2\n", + "looking for paths in the network with length: 2 for node PTK2 and CDH2\n", + "Found a path!\n", + "[['PTK2', 'RELB', 'CDH2'], ['PTK2', 'COMPLEX:P19838_Q04864', 'CDH2'], ['PTK2', 'COMPLEX:Q00653_Q01201', 'CDH2'], ['PTK2', 'SRC', 'CDH2'], ['PTK2', 'RELA', 'CDH2'], ['PTK2', 'NFKB1', 'CDH2'], ['PTK2', 'COMPLEX:Q00653_Q04206', 'CDH2'], ['PTK2', 'COMPLEX:P19838_Q04206', 'CDH2'], ['PTK2', 'COMPLEX:P19838_Q01201', 'CDH2'], ['PTK2', 'COMPLEX:Q04206_Q04864', 'CDH2'], ['PTK2', 'COMPLEX:P19838_Q00653', 'CDH2'], ['PTK2', 'REL', 'CDH2'], ['PTK2', 'COMPLEX:Q01201_Q04206', 'CDH2'], ['PTK2', 'COMPLEX:Q01201_Q04864', 'CDH2'], ['PTK2', 'NFKB2', 'CDH2'], ['PTK2', 'COMPLEX:Q00653_Q04864', 'CDH2']]\n", + "looking for paths in the network with length: 0 for node PTK2 and VIM\n", + "looking for paths in the network with length: 1 for node PTK2 and VIM\n", + "looking for paths in the network with length: 2 for node PTK2 and VIM\n", + "Found a path!\n", + "[['PTK2', 'RELB', 'VIM'], ['PTK2', 'COMPLEX:P19838_Q04864', 'VIM'], ['PTK2', 'COMPLEX:Q00653_Q01201', 'VIM'], ['PTK2', 'RELA', 'VIM'], ['PTK2', 'NFKB1', 'VIM'], ['PTK2', 'COMPLEX:Q00653_Q04206', 'VIM'], ['PTK2', 'COMPLEX:P19838_Q04206', 'VIM'], ['PTK2', 'COMPLEX:P19838_Q01201', 'VIM'], ['PTK2', 'COMPLEX:Q04206_Q04864', 'VIM'], ['PTK2', 'COMPLEX:P19838_Q00653', 'VIM'], ['PTK2', 'REL', 'VIM'], ['PTK2', 'COMPLEX:Q01201_Q04206', 'VIM'], ['PTK2', 'COMPLEX:Q01201_Q04864', 'VIM'], ['PTK2', 'NFKB2', 'VIM'], ['PTK2', 'COMPLEX:Q00653_Q04864', 'VIM']]\n", + "looking for paths in the network with length: 0 for node PTK2 and MAP4K4\n", + "looking for paths in the network with length: 1 for node PTK2 and MAP4K4\n", + "looking for paths in the network with length: 2 for node PTK2 and MAP4K4\n", + "Found a path!\n", + "[['PTK2', 'EPHB1', 'MAP4K4']]\n", + "looking for paths in the network with length: 0 for node PTK2 and PTK2B\n", + "looking for paths in the network with length: 1 for node PTK2 and PTK2B\n", + "Found a path!\n", + "[['PTK2', 'PTK2B']]\n", + "looking for paths in the network with length: 0 for node PTK2 and COL1A1\n", + "looking for paths in the network with length: 1 for node PTK2 and COL1A1\n", + "looking for paths in the network with length: 2 for node PTK2 and COL1A1\n", + "Found a path!\n", + "[['PTK2', 'SRC', 'COL1A1']]\n", + "looking for paths in the network with length: 0 for node CDH1 and CDH2\n", + "looking for paths in the network with length: 1 for node CDH1 and CDH2\n", + "looking for paths in the network with length: 2 for node CDH1 and CDH2\n", + "Found a path!\n", + "[['CDH1', 'COMPLEX:P15407_P17275', 'CDH2'], ['CDH1', 'COMPLEX:P05412_P53539', 'CDH2'], ['CDH1', 'COMPLEX:P05412_P17535', 'CDH2'], ['CDH1', 'COMPLEX:P17275_P53539', 'CDH2'], ['CDH1', 'COMPLEX:P05412_P15407', 'CDH2'], ['CDH1', 'COMPLEX:P05412_P17275', 'CDH2'], ['CDH1', 'COMPLEX:P01100_P17275', 'CDH2'], ['CDH1', 'NFKB1', 'CDH2'], ['CDH1', 'COMPLEX:P19838_Q04206', 'CDH2'], ['CDH1', 'JUND', 'CDH2'], ['CDH1', 'COMPLEX:P19838_Q00653', 'CDH2'], ['CDH1', 'REL', 'CDH2'], ['CDH1', 'COMPLEX:Q01201_Q04206', 'CDH2'], ['CDH1', 'COMPLEX:Q01201_Q04864', 'CDH2'], ['CDH1', 'NFKB2', 'CDH2'], ['CDH1', 'RELB', 'CDH2'], ['CDH1', 'COMPLEX:P05412_P15408', 'CDH2'], ['CDH1', 'COMPLEX:P19838_Q04864', 'CDH2'], ['CDH1', 'COMPLEX:Q00653_Q01201', 'CDH2'], ['CDH1', 'COMPLEX:P01100_P05412', 'CDH2'], ['CDH1', 'COMPLEX:P17535_P53539', 'CDH2'], ['CDH1', 'SRC', 'CDH2'], ['CDH1', 'COMPLEX:P15408_P17535', 'CDH2'], ['CDH1', 'JUN', 'CDH2'], ['CDH1', 'JUNB', 'CDH2'], ['CDH1', 'RELA', 'CDH2'], ['CDH1', 'PPARG', 'CDH2'], ['CDH1', 'COMPLEX:Q00653_Q04206', 'CDH2'], ['CDH1', 'COMPLEX:P19838_Q01201', 'CDH2'], ['CDH1', 'COMPLEX:P15408_P17275', 'CDH2'], ['CDH1', 'COMPLEX:P01100_P17535', 'CDH2'], ['CDH1', 'COMPLEX:Q04206_Q04864', 'CDH2'], ['CDH1', 'COMPLEX:P15407_P17535', 'CDH2'], ['CDH1', 'COMPLEX:P17275_P17535', 'CDH2'], ['CDH1', 'COMPLEX:Q00653_Q04864', 'CDH2']]\n", + "looking for paths in the network with length: 0 for node CDH1 and VIM\n", + "looking for paths in the network with length: 1 for node CDH1 and VIM\n", + "looking for paths in the network with length: 2 for node CDH1 and VIM\n", + "Found a path!\n", + "[['CDH1', 'COMPLEX:P15407_P17275', 'VIM'], ['CDH1', 'COMPLEX:P05412_P53539', 'VIM'], ['CDH1', 'COMPLEX:P05412_P17535', 'VIM'], ['CDH1', 'COMPLEX:P17275_P53539', 'VIM'], ['CDH1', 'COMPLEX:P05412_P15407', 'VIM'], ['CDH1', 'COMPLEX:P05412_P17275', 'VIM'], ['CDH1', 'COMPLEX:P01100_P17275', 'VIM'], ['CDH1', 'NFKB1', 'VIM'], ['CDH1', 'COMPLEX:P19838_Q04206', 'VIM'], ['CDH1', 'JUND', 'VIM'], ['CDH1', 'COMPLEX:P19838_Q00653', 'VIM'], ['CDH1', 'REL', 'VIM'], ['CDH1', 'COMPLEX:Q01201_Q04206', 'VIM'], ['CDH1', 'COMPLEX:Q01201_Q04864', 'VIM'], ['CDH1', 'NFKB2', 'VIM'], ['CDH1', 'RELB', 'VIM'], ['CDH1', 'COMPLEX:P05412_P15408', 'VIM'], ['CDH1', 'COMPLEX:P19838_Q04864', 'VIM'], ['CDH1', 'COMPLEX:Q00653_Q01201', 'VIM'], ['CDH1', 'COMPLEX:P01100_P05412', 'VIM'], ['CDH1', 'COMPLEX:P17535_P53539', 'VIM'], ['CDH1', 'COMPLEX:P15408_P17535', 'VIM'], ['CDH1', 'JUN', 'VIM'], ['CDH1', 'JUNB', 'VIM'], ['CDH1', 'RELA', 'VIM'], ['CDH1', 'COMPLEX:Q00653_Q04206', 'VIM'], ['CDH1', 'COMPLEX:P19838_Q01201', 'VIM'], ['CDH1', 'COMPLEX:P15408_P17275', 'VIM'], ['CDH1', 'COMPLEX:P01100_P17535', 'VIM'], ['CDH1', 'COMPLEX:Q04206_Q04864', 'VIM'], ['CDH1', 'COMPLEX:P15407_P17535', 'VIM'], ['CDH1', 'COMPLEX:P17275_P17535', 'VIM'], ['CDH1', 'COMPLEX:Q00653_Q04864', 'VIM']]\n", + "looking for paths in the network with length: 0 for node CDH1 and MAP4K4\n", + "looking for paths in the network with length: 1 for node CDH1 and MAP4K4\n", + "looking for paths in the network with length: 2 for node CDH1 and MAP4K4\n", + "Found a path!\n", + "[['CDH1', 'PPARG', 'MAP4K4']]\n", + "looking for paths in the network with length: 0 for node CDH1 and PTK2B\n", + "looking for paths in the network with length: 1 for node CDH1 and PTK2B\n", + "looking for paths in the network with length: 2 for node CDH1 and PTK2B\n", + "Found a path!\n", + "[['CDH1', 'COMPLEX:P15407_P17275', 'PTK2B'], ['CDH1', 'COMPLEX:P05412_P53539', 'PTK2B'], ['CDH1', 'COMPLEX:P05412_P17535', 'PTK2B'], ['CDH1', 'COMPLEX:P17275_P53539', 'PTK2B'], ['CDH1', 'COMPLEX:P05412_P15407', 'PTK2B'], ['CDH1', 'COMPLEX:P05412_P17275', 'PTK2B'], ['CDH1', 'COMPLEX:P01100_P17275', 'PTK2B'], ['CDH1', 'JUND', 'PTK2B'], ['CDH1', 'COMPLEX:P05412_P15408', 'PTK2B'], ['CDH1', 'COMPLEX:P01100_P05412', 'PTK2B'], ['CDH1', 'COMPLEX:P17535_P53539', 'PTK2B'], ['CDH1', 'SRC', 'PTK2B'], ['CDH1', 'COMPLEX:P15408_P17535', 'PTK2B'], ['CDH1', 'JUN', 'PTK2B'], ['CDH1', 'JUNB', 'PTK2B'], ['CDH1', 'COMPLEX:P15408_P17275', 'PTK2B'], ['CDH1', 'COMPLEX:P01100_P17535', 'PTK2B'], ['CDH1', 'COMPLEX:P15407_P17535', 'PTK2B'], ['CDH1', 'COMPLEX:P17275_P17535', 'PTK2B']]\n", + "looking for paths in the network with length: 0 for node CDH1 and COL1A1\n", + "looking for paths in the network with length: 1 for node CDH1 and COL1A1\n", + "looking for paths in the network with length: 2 for node CDH1 and COL1A1\n", + "Found a path!\n", + "[['CDH1', 'SRC', 'COL1A1']]\n", + "looking for paths in the network with length: 0 for node CDH2 and VIM\n", + "looking for paths in the network with length: 1 for node CDH2 and VIM\n", + "looking for paths in the network with length: 2 for node CDH2 and VIM\n", + "Found a path!\n", + "[['CDH2', 'COMPLEX:P15407_P17275', 'VIM'], ['CDH2', 'COMPLEX:P05412_P53539', 'VIM'], ['CDH2', 'COMPLEX:P05412_P17535', 'VIM'], ['CDH2', 'COMPLEX:P17275_P53539', 'VIM'], ['CDH2', 'COMPLEX:P05412_P15407', 'VIM'], ['CDH2', 'COMPLEX:P05412_P17275', 'VIM'], ['CDH2', 'COMPLEX:P01100_P17275', 'VIM'], ['CDH2', 'NFKB1', 'VIM'], ['CDH2', 'COMPLEX:P19838_Q04206', 'VIM'], ['CDH2', 'JUND', 'VIM'], ['CDH2', 'COMPLEX:P19838_Q00653', 'VIM'], ['CDH2', 'REL', 'VIM'], ['CDH2', 'COMPLEX:Q01201_Q04206', 'VIM'], ['CDH2', 'COMPLEX:Q01201_Q04864', 'VIM'], ['CDH2', 'NFKB2', 'VIM'], ['CDH2', 'RELB', 'VIM'], ['CDH2', 'COMPLEX:P05412_P15408', 'VIM'], ['CDH2', 'COMPLEX:P19838_Q04864', 'VIM'], ['CDH2', 'COMPLEX:Q00653_Q01201', 'VIM'], ['CDH2', 'COMPLEX:P01100_P05412', 'VIM'], ['CDH2', 'COMPLEX:P17535_P53539', 'VIM'], ['CDH2', 'COMPLEX:P15408_P17535', 'VIM'], ['CDH2', 'JUN', 'VIM'], ['CDH2', 'JUNB', 'VIM'], ['CDH2', 'RELA', 'VIM'], ['CDH2', 'COMPLEX:Q00653_Q04206', 'VIM'], ['CDH2', 'COMPLEX:P19838_Q01201', 'VIM'], ['CDH2', 'COMPLEX:P15408_P17275', 'VIM'], ['CDH2', 'COMPLEX:P01100_P17535', 'VIM'], ['CDH2', 'COMPLEX:Q04206_Q04864', 'VIM'], ['CDH2', 'COMPLEX:P15407_P17535', 'VIM'], ['CDH2', 'COMPLEX:P17275_P17535', 'VIM'], ['CDH2', 'COMPLEX:Q00653_Q04864', 'VIM']]\n", + "looking for paths in the network with length: 0 for node CDH2 and MAP4K4\n", + "looking for paths in the network with length: 1 for node CDH2 and MAP4K4\n", + "looking for paths in the network with length: 2 for node CDH2 and MAP4K4\n", + "Found a path!\n", + "[['CDH2', 'PPARG', 'MAP4K4']]\n", + "looking for paths in the network with length: 0 for node CDH2 and PTK2B\n", + "looking for paths in the network with length: 1 for node CDH2 and PTK2B\n", + "looking for paths in the network with length: 2 for node CDH2 and PTK2B\n", + "Found a path!\n", + "[['CDH2', 'COMPLEX:P15407_P17275', 'PTK2B'], ['CDH2', 'COMPLEX:P05412_P53539', 'PTK2B'], ['CDH2', 'COMPLEX:P05412_P17535', 'PTK2B'], ['CDH2', 'COMPLEX:P17275_P53539', 'PTK2B'], ['CDH2', 'COMPLEX:P05412_P15407', 'PTK2B'], ['CDH2', 'COMPLEX:P05412_P17275', 'PTK2B'], ['CDH2', 'COMPLEX:P01100_P17275', 'PTK2B'], ['CDH2', 'JUND', 'PTK2B'], ['CDH2', 'COMPLEX:P05412_P15408', 'PTK2B'], ['CDH2', 'COMPLEX:P01100_P05412', 'PTK2B'], ['CDH2', 'COMPLEX:P17535_P53539', 'PTK2B'], ['CDH2', 'SRC', 'PTK2B'], ['CDH2', 'COMPLEX:P15408_P17535', 'PTK2B'], ['CDH2', 'JUN', 'PTK2B'], ['CDH2', 'JUNB', 'PTK2B'], ['CDH2', 'COMPLEX:P15408_P17275', 'PTK2B'], ['CDH2', 'COMPLEX:P01100_P17535', 'PTK2B'], ['CDH2', 'COMPLEX:P15407_P17535', 'PTK2B'], ['CDH2', 'COMPLEX:P17275_P17535', 'PTK2B']]\n", + "looking for paths in the network with length: 0 for node CDH2 and COL1A1\n", + "looking for paths in the network with length: 1 for node CDH2 and COL1A1\n", + "looking for paths in the network with length: 2 for node CDH2 and COL1A1\n", + "Found a path!\n", + "[['CDH2', 'SRC', 'COL1A1'], ['CDH2', 'NOTCH1', 'COL1A1']]\n", + "looking for paths in the network with length: 0 for node VIM and MAP4K4\n", + "looking for paths in the network with length: 1 for node VIM and MAP4K4\n", + "looking for paths in the network with length: 2 for node VIM and MAP4K4\n", + "looking for paths in the network with length: 3 for node VIM and MAP4K4\n", + "Found a path!\n", + "[['VIM', 'STAT5A', 'PPARG', 'MAP4K4'], ['VIM', 'COMPLEX:P15407_P17275', 'PPARG', 'MAP4K4'], ['VIM', 'COMPLEX:P05412_P53539', 'PPARG', 'MAP4K4'], ['VIM', 'COMPLEX:P05412_P17535', 'PPARG', 'MAP4K4'], ['VIM', 'COMPLEX:P17275_P53539', 'PPARG', 'MAP4K4'], ['VIM', 'COMPLEX:P05412_P15407', 'PPARG', 'MAP4K4'], ['VIM', 'COMPLEX:P05412_P17275', 'PPARG', 'MAP4K4'], ['VIM', 'COMPLEX:P01100_P17275', 'PPARG', 'MAP4K4'], ['VIM', 'NFKB1', 'PPARG', 'MAP4K4'], ['VIM', 'COMPLEX:P19838_Q04206', 'PPARG', 'MAP4K4'], ['VIM', 'JUND', 'PPARG', 'MAP4K4'], ['VIM', 'COMPLEX:P19838_Q00653', 'PPARG', 'MAP4K4'], ['VIM', 'REL', 'PPARG', 'MAP4K4'], ['VIM', 'NFKB1', 'MAP3K2', 'MAP4K4'], ['VIM', 'NFKB1', 'PPARG', 'MAP4K4'], ['VIM', 'COMPLEX:Q01201_Q04206', 'PPARG', 'MAP4K4'], ['VIM', 'COMPLEX:Q01201_Q04864', 'PPARG', 'MAP4K4'], ['VIM', 'NFKB2', 'PPARG', 'MAP4K4'], ['VIM', 'RELB', 'PPARG', 'MAP4K4'], ['VIM', 'COMPLEX:P05412_P15408', 'PPARG', 'MAP4K4'], ['VIM', 'COMPLEX:P19838_Q04864', 'PPARG', 'MAP4K4'], ['VIM', 'COMPLEX:Q00653_Q01201', 'PPARG', 'MAP4K4'], ['VIM', 'COMPLEX:P01100_P05412', 'PPARG', 'MAP4K4'], ['VIM', 'COMPLEX:P17535_P53539', 'PPARG', 'MAP4K4'], ['VIM', 'COMPLEX:P15408_P17535', 'PPARG', 'MAP4K4'], ['VIM', 'JUN', 'PPARG', 'MAP4K4'], ['VIM', 'JUNB', 'PPARG', 'MAP4K4'], ['VIM', 'RELA', 'PPARG', 'MAP4K4'], ['VIM', 'SP1', 'EPHB1', 'MAP4K4'], ['VIM', 'SP1', 'PPARG', 'MAP4K4'], ['VIM', 'COMPLEX:Q00653_Q04206', 'PPARG', 'MAP4K4'], ['VIM', 'COMPLEX:P19838_Q01201', 'PPARG', 'MAP4K4'], ['VIM', 'COMPLEX:P15408_P17275', 'PPARG', 'MAP4K4'], ['VIM', 'COMPLEX:P01100_P17535', 'PPARG', 'MAP4K4'], ['VIM', 'COMPLEX:Q04206_Q04864', 'PPARG', 'MAP4K4'], ['VIM', 'COMPLEX:P15407_P17535', 'PPARG', 'MAP4K4'], ['VIM', 'COMPLEX:P17275_P17535', 'PPARG', 'MAP4K4'], ['VIM', 'COMPLEX:Q00653_Q04864', 'PPARG', 'MAP4K4']]\n", + "looking for paths in the network with length: 0 for node VIM and PTK2B\n", + "looking for paths in the network with length: 1 for node VIM and PTK2B\n", + "looking for paths in the network with length: 2 for node VIM and PTK2B\n", + "Found a path!\n", + "[['VIM', 'COMPLEX:P15407_P17275', 'PTK2B'], ['VIM', 'COMPLEX:P05412_P53539', 'PTK2B'], ['VIM', 'COMPLEX:P05412_P17535', 'PTK2B'], ['VIM', 'COMPLEX:P17275_P53539', 'PTK2B'], ['VIM', 'COMPLEX:P05412_P15407', 'PTK2B'], ['VIM', 'COMPLEX:P05412_P17275', 'PTK2B'], ['VIM', 'COMPLEX:P01100_P17275', 'PTK2B'], ['VIM', 'JUND', 'PTK2B'], ['VIM', 'COMPLEX:P05412_P15408', 'PTK2B'], ['VIM', 'COMPLEX:P01100_P05412', 'PTK2B'], ['VIM', 'COMPLEX:P17535_P53539', 'PTK2B'], ['VIM', 'COMPLEX:P15408_P17535', 'PTK2B'], ['VIM', 'JUN', 'PTK2B'], ['VIM', 'JUNB', 'PTK2B'], ['VIM', 'COMPLEX:P15408_P17275', 'PTK2B'], ['VIM', 'COMPLEX:P01100_P17535', 'PTK2B'], ['VIM', 'COMPLEX:P15407_P17535', 'PTK2B'], ['VIM', 'COMPLEX:P17275_P17535', 'PTK2B']]\n", + "looking for paths in the network with length: 0 for node VIM and COL1A1\n", + "looking for paths in the network with length: 1 for node VIM and COL1A1\n", + "looking for paths in the network with length: 2 for node VIM and COL1A1\n", + "Found a path!\n", + "[['VIM', 'SP3', 'COL1A1'], ['VIM', 'NFKB1', 'COL1A1'], ['VIM', 'SP1', 'COL1A1']]\n", + "looking for paths in the network with length: 0 for node MAP4K4 and PTK2B\n", + "looking for paths in the network with length: 1 for node MAP4K4 and PTK2B\n", + "looking for paths in the network with length: 2 for node MAP4K4 and PTK2B\n" + ] + }, + { + "name": "stdout", + "output_type": "stream", + "text": [ + "looking for paths in the network with length: 3 for node MAP4K4 and PTK2B\n", + "Found a path!\n", + "[['MAP4K4', 'EPHB1', 'PTK2', 'PTK2B'], ['MAP4K4', 'EPHB1', 'SRC', 'PTK2B'], ['MAP4K4', 'PPARG', 'COMPLEX:P15407_P17275', 'PTK2B'], ['MAP4K4', 'PPARG', 'COMPLEX:P05412_P53539', 'PTK2B'], ['MAP4K4', 'PPARG', 'COMPLEX:P05412_P17535', 'PTK2B'], ['MAP4K4', 'PPARG', 'COMPLEX:P17275_P53539', 'PTK2B'], ['MAP4K4', 'PPARG', 'COMPLEX:P05412_P15407', 'PTK2B'], ['MAP4K4', 'PPARG', 'COMPLEX:P05412_P17275', 'PTK2B'], ['MAP4K4', 'PPARG', 'COMPLEX:P01100_P17275', 'PTK2B'], ['MAP4K4', 'PPARG', 'JUND', 'PTK2B'], ['MAP4K4', 'PPARG', 'COMPLEX:P05412_P15408', 'PTK2B'], ['MAP4K4', 'PPARG', 'COMPLEX:P01100_P05412', 'PTK2B'], ['MAP4K4', 'PPARG', 'COMPLEX:P17535_P53539', 'PTK2B'], ['MAP4K4', 'PPARG', 'SRC', 'PTK2B'], ['MAP4K4', 'PPARG', 'COMPLEX:P15408_P17535', 'PTK2B'], ['MAP4K4', 'PPARG', 'JUN', 'PTK2B'], ['MAP4K4', 'PPARG', 'JUNB', 'PTK2B'], ['MAP4K4', 'PPARG', 'COMPLEX:P15408_P17275', 'PTK2B'], ['MAP4K4', 'PPARG', 'COMPLEX:P01100_P17535', 'PTK2B'], ['MAP4K4', 'PPARG', 'COMPLEX:P15407_P17535', 'PTK2B'], ['MAP4K4', 'PPARG', 'COMPLEX:P17275_P17535', 'PTK2B'], ['MAP4K4', 'MAP3K2', 'SRC', 'PTK2B']]\n", + "looking for paths in the network with length: 0 for node MAP4K4 and COL1A1\n", + "looking for paths in the network with length: 1 for node MAP4K4 and COL1A1\n", + "looking for paths in the network with length: 2 for node MAP4K4 and COL1A1\n", + "looking for paths in the network with length: 3 for node MAP4K4 and COL1A1\n", + "Found a path!\n", + "[['MAP4K4', 'EPHB1', 'SP1', 'COL1A1'], ['MAP4K4', 'EPHB1', 'SRC', 'COL1A1'], ['MAP4K4', 'PPARG', 'NFKB1', 'COL1A1'], ['MAP4K4', 'PPARG', 'SRC', 'COL1A1'], ['MAP4K4', 'PPARG', 'NOTCH1', 'COL1A1'], ['MAP4K4', 'PPARG', 'SP1', 'COL1A1'], ['MAP4K4', 'MAP3K2', 'NFKB1', 'COL1A1'], ['MAP4K4', 'MAP3K2', 'SRC', 'COL1A1']]\n", + "looking for paths in the network with length: 0 for node PTK2B and COL1A1\n", + "looking for paths in the network with length: 1 for node PTK2B and COL1A1\n", + "looking for paths in the network with length: 2 for node PTK2B and COL1A1\n", + "Found a path!\n", + "[['PTK2B', 'SRC', 'COL1A1']]\n", + "CPU times: user 2min 4s, sys: 36.8 ms, total: 2min 4s\n", + "Wall time: 2min 4s\n" + ] + } + ], + "source": [ + "%%time\n", + "new_net1.complete_connection(mode=\"ALL\", maxlen=6, k_mean=\"tight\", only_signed=True,\n", + " consensus=True, connect_node_when_first_introduced=True)" + ] + }, + { + "cell_type": "code", + "execution_count": 17, + "id": "db61c89d", + "metadata": {}, + "outputs": [ + { + "data": { + "image/svg+xml": [ + "\n", + "\n", + "\n", + "\n", + "\n", + "\n", + "%3\n", + "\n", + "\n", + "\n", + "SRC\n", + "\n", + "SRC\n", + "\n", + "\n", + "\n", + "PTK2\n", + "\n", + "PTK2\n", + "\n", + "\n", + "\n", + "SRC->PTK2\n", + "\n", + "\n", + "\n", + "\n", + "\n", + "CDH2\n", + "\n", + "CDH2\n", + "\n", + "\n", + "\n", + "SRC->CDH2\n", + "\n", + "\n", + "\n", + "\n", + "\n", + "\n", + "PTK2B\n", + "\n", + "PTK2B\n", + "\n", + "\n", + "\n", + "SRC->PTK2B\n", + "\n", + "\n", 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"\n", + "\n", + "P01100_P17535->CDH2\n", + "\n", + "\n", + "\n", + "\n", + "\n", + "\n", + "P01100_P17535->PTK2B\n", + "\n", + "\n", + "\n", + "\n", + "\n", + "P01100_P17535->VIM\n", + "\n", + "\n", + "\n", + "\n", + "\n", + "P01100_P17535->NFKB1\n", + "\n", + "\n", + "\n", + "\n", + "\n", + "\n", + "P01100_P17535->SP1\n", + "\n", + "\n", + "\n", + "\n", + "\n", + "P01100_P17535->SP3\n", + "\n", + "\n", + "\n", + "\n", + "\n", + "P01100_P17535->PPARG\n", + "\n", + "\n", + "\n", + "\n", + "\n", + "\n", + "Q04206_Q04864\n", + "\n", + "Q04206_Q04864\n", + "\n", + "\n", + "\n", + "Q04206_Q04864->SRC\n", + "\n", + "\n", + "\n", + "\n", + "\n", + "Q04206_Q04864->PTK2\n", + "\n", + "\n", + "\n", + "\n", + "\n", + "Q04206_Q04864->CDH1\n", + "\n", + "\n", + "\n", + "\n", + "\n", + "Q04206_Q04864->CDH2\n", + "\n", + "\n", + "\n", + "\n", + "\n", + "Q04206_Q04864->NOTCH1\n", + "\n", + "\n", + "\n", + "\n", + "\n", + "Q04206_Q04864->VIM\n", + "\n", + "\n", + "\n", + "\n", + "\n", + "Q04206_Q04864->NFKB1\n", + "\n", + "\n", + "\n", + "\n", + "\n", + "Q04206_Q04864->SP1\n", + "\n", + "\n", + "\n", + "\n", + "\n", + "Q04206_Q04864->SP3\n", + "\n", + "\n", + "\n", + "\n", + "\n", + "Q04206_Q04864->STAT5A\n", + "\n", + "\n", + "\n", + "\n", + "\n", + "Q04206_Q04864->HNF4A\n", + "\n", + "\n", + "\n", + "\n", + "\n", + "\n", + "Q04206_Q04864->PPARG\n", + "\n", + "\n", + "\n", + "\n", + "\n", + "\n", + "HIPK2->VIM\n", + "\n", + "\n", + "\n", + "\n", + "\n", + "\n", + "Q01201_Q04864\n", + "\n", + "Q01201_Q04864\n", + "\n", + "\n", + "\n", + "Q01201_Q04864->SRC\n", + "\n", + "\n", + "\n", + "\n", + "\n", + "Q01201_Q04864->PTK2\n", + "\n", + "\n", + "\n", + "\n", + "\n", + "Q01201_Q04864->CDH1\n", + "\n", + "\n", + "\n", + "\n", + "\n", + "Q01201_Q04864->CDH2\n", + "\n", + "\n", + "\n", + "\n", + "\n", + "Q01201_Q04864->NOTCH1\n", + "\n", + "\n", + "\n", + "\n", + "\n", + "Q01201_Q04864->VIM\n", + "\n", + "\n", + "\n", + "\n", + "\n", + "Q01201_Q04864->NFKB1\n", + "\n", + "\n", + "\n", + "\n", + "\n", + "Q01201_Q04864->SP1\n", + "\n", + "\n", + "\n", + "\n", + "\n", + "Q01201_Q04864->SP3\n", + "\n", + "\n", + "\n", + "\n", + "\n", + "Q01201_Q04864->STAT5A\n", + "\n", + "\n", + "\n", + "\n", + "\n", + "Q01201_Q04864->HNF4A\n", + "\n", + "\n", + "\n", + "\n", + "\n", + "\n", + "Q01201_Q04864->PPARG\n", + "\n", + "\n", + "\n", + "\n", + "\n", + "\n", + "NFKB2\n", + "\n", + "NFKB2\n", + "\n", + "\n", + "\n", + "NFKB2->SRC\n", + "\n", + "\n", + "\n", + "\n", + "\n", + "NFKB2->PTK2\n", + "\n", + "\n", + "\n", + "\n", + "\n", + "NFKB2->CDH1\n", + "\n", + "\n", + "\n", + "\n", + "\n", + "NFKB2->CDH2\n", + "\n", + "\n", + "\n", + "\n", + "\n", + "NFKB2->NOTCH1\n", + "\n", + "\n", + "\n", + "\n", + "\n", + "NFKB2->VIM\n", + "\n", + "\n", + "\n", + "\n", + "\n", + "NFKB2->NFKB1\n", + "\n", + "\n", + "\n", + "\n", + "\n", + "NFKB2->SP1\n", + "\n", + "\n", + "\n", + "\n", + "\n", + "NFKB2->SP3\n", + "\n", + "\n", + "\n", + "\n", + "\n", + "NFKB2->STAT5A\n", + "\n", + "\n", + "\n", + "\n", + "\n", + "NFKB2->HNF4A\n", + "\n", + "\n", + "\n", + "\n", + "\n", + "\n", + "NFKB2->PPARG\n", + "\n", + "\n", + "\n", + "\n", + "\n", + "\n", + "Q00653_Q04864\n", + "\n", + "Q00653_Q04864\n", + "\n", + "\n", + "\n", + "Q00653_Q04864->SRC\n", + "\n", + "\n", + "\n", + "\n", + "\n", + "Q00653_Q04864->PTK2\n", + "\n", + "\n", + "\n", + "\n", + "\n", + "Q00653_Q04864->CDH1\n", + "\n", + "\n", + "\n", + "\n", + "\n", + "Q00653_Q04864->CDH2\n", + "\n", + "\n", + "\n", + "\n", + "\n", + "Q00653_Q04864->NOTCH1\n", + "\n", + "\n", + "\n", + "\n", + "\n", + "Q00653_Q04864->VIM\n", + "\n", + "\n", + "\n", + "\n", + "\n", + "Q00653_Q04864->NFKB1\n", + "\n", + "\n", + "\n", + "\n", + "\n", + "Q00653_Q04864->SP1\n", + "\n", + "\n", + "\n", + "\n", + "\n", + "Q00653_Q04864->SP3\n", + "\n", + "\n", + "\n", + "\n", + "\n", + "Q00653_Q04864->STAT5A\n", + "\n", + "\n", + "\n", + "\n", + "\n", + "Q00653_Q04864->HNF4A\n", + "\n", + "\n", + "\n", + "\n", + "\n", + "\n", + "Q00653_Q04864->PPARG\n", + "\n", + "\n", + "\n", + "\n", + "\n", + "\n", + "Q01201_Q04206\n", + "\n", + "Q01201_Q04206\n", + "\n", + "\n", + "\n", + "Q01201_Q04206->SRC\n", + "\n", + "\n", + "\n", + "\n", + "\n", + "Q01201_Q04206->PTK2\n", + "\n", + "\n", + "\n", + "\n", + "\n", + "Q01201_Q04206->CDH1\n", + "\n", + "\n", + "\n", + "\n", + "\n", + "Q01201_Q04206->CDH2\n", + "\n", + "\n", + "\n", + "\n", + "\n", + "Q01201_Q04206->NOTCH1\n", + "\n", + "\n", + "\n", + "\n", + "\n", + "Q01201_Q04206->VIM\n", + "\n", + "\n", + "\n", + "\n", + "\n", + "Q01201_Q04206->NFKB1\n", + "\n", + "\n", + "\n", + "\n", + "\n", + "Q01201_Q04206->SP1\n", + "\n", + "\n", + "\n", + "\n", + "\n", + "Q01201_Q04206->SP3\n", + "\n", + "\n", + "\n", + "\n", + "\n", + "Q01201_Q04206->STAT5A\n", + "\n", + "\n", + "\n", + "\n", + "\n", + "Q01201_Q04206->HNF4A\n", + "\n", + "\n", + "\n", + "\n", + "\n", + "\n", + "Q01201_Q04206->PPARG\n", + "\n", + "\n", + "\n", + "\n", + "\n", + "\n", + "P05412_P15408\n", + "\n", + "P05412_P15408\n", + "\n", + "\n", + "\n", + "P05412_P15408->SRC\n", + "\n", + "\n", + "\n", + "\n", + "\n", + "P05412_P15408->CDH1\n", + "\n", + "\n", + "\n", + "\n", + "\n", + "P05412_P15408->CDH2\n", + "\n", + "\n", + "\n", + "\n", + "\n", + "\n", + "P05412_P15408->PTK2B\n", + "\n", + "\n", + "\n", + "\n", + "\n", + "P05412_P15408->VIM\n", + "\n", + "\n", + "\n", + "\n", + "\n", + "P05412_P15408->NFKB1\n", + "\n", + "\n", + "\n", + "\n", + "\n", + "\n", + "P05412_P15408->SP1\n", + "\n", + "\n", + "\n", + "\n", + "\n", + "P05412_P15408->SP3\n", + "\n", + "\n", + "\n", + "\n", + "\n", + "P05412_P15408->PPARG\n", + "\n", + "\n", + "\n", + "\n", + "\n", + "\n", + "P17275_P17535\n", + "\n", + "P17275_P17535\n", + "\n", + "\n", + "\n", + "P17275_P17535->SRC\n", + "\n", + "\n", + "\n", + "\n", + "\n", + "P17275_P17535->CDH1\n", + "\n", + "\n", + "\n", + "\n", + "\n", + "P17275_P17535->CDH2\n", + "\n", + "\n", + "\n", + "\n", + "\n", + "\n", + "P17275_P17535->PTK2B\n", + "\n", + "\n", + "\n", + "\n", + "\n", + "P17275_P17535->VIM\n", + "\n", + "\n", + "\n", + "\n", + "\n", + "P17275_P17535->NFKB1\n", + "\n", + "\n", + "\n", + "\n", + "\n", + "\n", + "P17275_P17535->SP1\n", + "\n", + "\n", + "\n", + "\n", + "\n", + "P17275_P17535->SP3\n", + "\n", + "\n", + "\n", + "\n", + "\n", + "P17275_P17535->PPARG\n", + "\n", + "\n", + "\n", + "\n", + "\n", + "\n", + "MAP3K2->NFKB1\n", + "\n", + "\n", + "\n", + "\n", + "\n", + "MAP4K4\n", + "\n", + "MAP4K4\n", + "\n", + "\n", + "\n", + "MAP4K4->MAP3K2\n", + "\n", + "\n", + "\n", + "\n", + "\n", + "EPHB1->SRC\n", + "\n", + "\n", + "\n", + "\n", + "\n", + "EPHB1->PTK2\n", + "\n", + "\n", + "\n", + "\n", + "\n", + "\n", + "EPHB1->MAP4K4\n", + "\n", + "\n", + "\n", + "\n", + "\n", + "PPARG->CDH1\n", + "\n", + "\n", + "\n", + "\n", + "\n", + "PPARG->CDH2\n", + "\n", + "\n", + "\n", + "\n", + "\n", + "\n", + "PPARG->NFKB1\n", + "\n", + "\n", + "\n", + "\n", + "\n", + "\n", + "PPARG->SP1\n", + "\n", + "\n", + "\n", + "\n", + "\n", + "PPARG->STAT5A\n", + "\n", + "\n", + "\n", + "\n", + "\n", + "\n", + "PPARG->MAP4K4\n", + "\n", + "\n", + "\n", + "\n", + "\n", + "\n" + ], + "text/plain": [ + "" + ] + }, + "metadata": {}, + "output_type": "display_data" + } + ], + "source": [ + "visualizer = NetworkVisualizer(new_net1, color_by='effect')\n", + "visualizer.render()" + ] + }, + { + "cell_type": "markdown", + "id": "8361d2b2-646b-4080-bc36-ca28c9bfab10", + "metadata": {}, + "source": [ + "## The whole tool, as the name suggest, is based on Omnipath. But the user can also integrate its own databases. As example, we show how to integrate the Signor database. In order to do so, the User needs to have already downloaded the whole Signor database, available at the following link: https://signor.uniroma2.it/downloads.php \n", + "## Omniflow has been conceived to be a modular tool, with the possibility to add new databases. Every time a User wants to add a database, it should prepare an apposite function in the Resources module, in order to convert the target database, in the Omniflow format. We suggest to use as example, the function created for the Signor database. In future releases we plan to add more function to include more databases." + ] + }, + { + "cell_type": "code", + "execution_count": 16, + "id": "4fd4b190-350a-4682-8f09-8c6423064038", + "metadata": {}, + "outputs": [], + "source": [ + "resources = Resources()\n", + "resources.import_signor_tsv(\"./all_data_18_03_24.tsv\") # this function accept only tab separated values" + ] + }, + { + "cell_type": "code", + "execution_count": 23, + "id": "1ee6984a-1a6e-410e-b335-9acc1359b359", + "metadata": {}, + "outputs": [ + { + "name": "stdout", + "output_type": "stream", + "text": [ + "CPU times: user 32.3 ms, sys: 2 µs, total: 32.3 ms\n", + "Wall time: 31.6 ms\n" + ] + } + ], + "source": [ + "%%time\n", + "new_net1 = Network(genes, resources=resources.interactions) # here we load the signor interactions" + ] + }, + { + "cell_type": "markdown", + "id": "7aae5ca7-5696-44ba-9e75-4a2d1eb0a2d9", + "metadata": {}, + "source": [ + "## It is important to note, that not all the databases have the same structure as Omnipath. In particular, if the columns \"consensus\" are missing, we suggest to avoid to use the flag \"consensus\" or \"consensus_only\" when using Omniflow with customize databases." + ] + }, + { + "cell_type": "code", + "execution_count": 24, + "id": "12052b3b-854f-41a0-a762-20de5cbc7b35", + "metadata": {}, + "outputs": [ + { + "name": "stdout", + "output_type": "stream", + "text": [ + "looking for paths in the network with length: 0 for node FOXA1 and GRHL1\n", + "looking for paths in the network with length: 1 for node FOXA1 and GRHL1\n", + "looking for paths in the network with length: 2 for node FOXA1 and GRHL1\n", + "looking for paths in the network with length: 3 for node FOXA1 and GRHL1\n", + "looking for paths in the network with length: 4 for node FOXA1 and GRHL1\n", + "looking for paths in the network with length: 5 for node FOXA1 and GRHL1\n", + "looking for paths in the network with length: 6 for node FOXA1 and GRHL1\n", + "i_search = 3\n", + "Looking for paths with length: 0 for node FOXA1 and GRHL1\n", + "i_search = 3\n", + "Looking for paths with length: 1 for node FOXA1 and GRHL1\n", + "i_search = 3\n", + "Looking for paths with length: 2 for node FOXA1 and GRHL1\n", + "i_search = 3\n", + "Looking for paths with length: 3 for node FOXA1 and GRHL1\n", + "looking for paths in the network with length: 0 for node FOXA1 and GRHL3\n", + "looking for paths in the network with length: 1 for node FOXA1 and GRHL3\n", + "looking for paths in the network with length: 2 for node FOXA1 and GRHL3\n", + "looking for paths in the network with length: 3 for node FOXA1 and GRHL3\n", + "looking for paths in the network with length: 4 for node FOXA1 and GRHL3\n", + "looking for paths in the network with length: 5 for node FOXA1 and GRHL3\n", + "looking for paths in the network with length: 6 for node FOXA1 and GRHL3\n", + "i_search = 3\n", + "Looking for paths with length: 0 for node FOXA1 and GRHL3\n", + "i_search = 3\n", + "Looking for paths with length: 1 for node FOXA1 and GRHL3\n", + "i_search = 3\n", + "Looking for paths with length: 2 for node FOXA1 and GRHL3\n", + "i_search = 3\n", + "Looking for paths with length: 3 for node FOXA1 and GRHL3\n", + "looking for paths in the network with length: 0 for node FOXA1 and EHF\n", + "looking for paths in the network with length: 1 for node FOXA1 and EHF\n", + "looking for paths in the network with length: 2 for node FOXA1 and EHF\n", + "looking for paths in the network with length: 3 for node FOXA1 and EHF\n", + "looking for paths in the network with length: 4 for node FOXA1 and EHF\n", + "looking for paths in the network with length: 5 for node FOXA1 and EHF\n", + "looking for paths in the network with length: 6 for node FOXA1 and EHF\n", + "i_search = 3\n", + "Looking for paths with length: 0 for node FOXA1 and EHF\n", + "i_search = 3\n", + "Looking for paths with length: 1 for node FOXA1 and EHF\n", + "i_search = 3\n", + "Looking for paths with length: 2 for node FOXA1 and EHF\n", + "i_search = 3\n", + "Looking for paths with length: 3 for node FOXA1 and EHF\n", + "looking for paths in the network with length: 0 for node FOXA1 and KLF5\n", + "looking for paths in the network with length: 1 for node FOXA1 and KLF5\n", + "looking for paths in the network with length: 2 for node FOXA1 and KLF5\n", + "looking for paths in the network with length: 3 for node FOXA1 and KLF5\n", + "looking for paths in the network with length: 4 for node FOXA1 and KLF5\n", + "looking for paths in the network with length: 5 for node FOXA1 and KLF5\n", + "looking for paths in the network with length: 6 for node FOXA1 and KLF5\n", + "i_search = 3\n", + "Looking for paths with length: 0 for node FOXA1 and KLF5\n", + "i_search = 3\n", + "Looking for paths with length: 1 for node FOXA1 and KLF5\n", + "i_search = 3\n", + "Looking for paths with length: 2 for node FOXA1 and KLF5\n", + "i_search = 3\n", + "Looking for paths with length: 3 for node FOXA1 and KLF5\n", + "[['FOXA1', 'HSPA1A', 'NR3C1', 'KLF5'], ['FOXA1', 'AR', 'NR3C1', 'KLF5']]\n", + "P55317 P0DMV8\n", + "P0DMV8 P04150\n", + "P04150 Q13887\n", + "P55317 P10275\n", + "P10275 P04150\n", + "P04150 Q13887\n", + "P55317 P0DMV8\n", + "P55317 P10275\n", + "P17676 Q13887\n", + "P04150 Q13887\n", + "P04150 P17676\n", + "P0DMV8 P04150\n", + "P04150 P10275\n", + "P10275 P04150\n", + "looking for paths in the network with length: 0 for node FOXA1 and HOXA9\n", + "looking for paths in the network with length: 1 for node FOXA1 and HOXA9\n", + "looking for paths in the network with length: 2 for node FOXA1 and HOXA9\n", + "looking for paths in the network with length: 3 for node FOXA1 and HOXA9\n", + "looking for paths in the network with length: 4 for node FOXA1 and HOXA9\n", + "looking for paths in the network with length: 5 for node FOXA1 and HOXA9\n", + "looking for paths in the network with length: 6 for node FOXA1 and HOXA9\n", + "i_search = 3\n", + "Looking for paths with length: 0 for node FOXA1 and HOXA9\n", + "i_search = 3\n", + "Looking for paths with length: 1 for node FOXA1 and HOXA9\n", + "i_search = 3\n", + "Looking for paths with length: 2 for node FOXA1 and HOXA9\n", + "i_search = 3\n", + "Looking for paths with length: 3 for node FOXA1 and HOXA9\n", + "[['FOXA1', 'NFIB', 'EZH2', 'HOXA9']]\n", + "P55317 O00712\n", + "O00712 Q15910\n", + "Q15910 P31269\n", + "P55317 P0DMV8\n", + "P55317 P10275\n", + "P55317 O00712\n", + "P17676 Q13887\n", + "P04150 Q13887\n", + "Q15910 P31269\n", + "Q15910 P31260\n", + "O00712 P41161\n", + "P04150 P17676\n", + "P0DMV8 P04150\n", + "P04150 P10275\n", + "P10275 P04150\n", + "Q15910 P10275\n", + "O00712 Q15910\n", + "looking for paths in the network with length: 0 for node FOXA1 and HOXA10\n", + "looking for paths in the network with length: 1 for node FOXA1 and HOXA10\n", + "looking for paths in the network with length: 2 for node FOXA1 and HOXA10\n", + "looking for paths in the network with length: 3 for node FOXA1 and HOXA10\n", + "Found a path!\n", + "[['FOXA1', 'NFIB', 'EZH2', 'HOXA10']]\n", + "looking for paths in the network with length: 0 for node FOXA1 and ETV4\n", + "looking for paths in the network with length: 1 for node FOXA1 and ETV4\n", + "looking for paths in the network with length: 2 for node FOXA1 and ETV4\n", + "looking for paths in the network with length: 3 for node FOXA1 and ETV4\n", + "looking for paths in the network with length: 4 for node FOXA1 and ETV4\n", + "looking for paths in the network with length: 5 for node FOXA1 and ETV4\n", + "looking for paths in the network with length: 6 for node FOXA1 and ETV4\n", + "i_search = 3\n", + "Looking for paths with length: 0 for node FOXA1 and ETV4\n", + "i_search = 3\n", + "Looking for paths with length: 1 for node FOXA1 and ETV4\n", + "i_search = 3\n", + "Looking for paths with length: 2 for node FOXA1 and ETV4\n", + "i_search = 3\n", + "Looking for paths with length: 3 for node FOXA1 and ETV4\n", + "looking for paths in the network with length: 0 for node FOXA1 and ETV5\n", + "looking for paths in the network with length: 1 for node FOXA1 and ETV5\n", + "looking for paths in the network with length: 2 for node FOXA1 and ETV5\n", + "Found a path!\n", + "[['FOXA1', 'NFIB', 'ETV5']]\n", + "looking for paths in the network with length: 0 for node FOXA1 and POU3F1\n", + "looking for paths in the network with length: 1 for node FOXA1 and POU3F1\n", + "looking for paths in the network with length: 2 for node FOXA1 and POU3F1\n", + "looking for paths in the network with length: 3 for node FOXA1 and POU3F1\n", + "looking for paths in the network with length: 4 for node FOXA1 and POU3F1\n", + "looking for paths in the network with length: 5 for node FOXA1 and POU3F1\n", + "looking for paths in the network with length: 6 for node FOXA1 and POU3F1\n", + "i_search = 3\n", + "Looking for paths with length: 0 for node FOXA1 and POU3F1\n", + "i_search = 3\n", + "Looking for paths with length: 1 for node FOXA1 and POU3F1\n", + "i_search = 3\n", + "Looking for paths with length: 2 for node FOXA1 and POU3F1\n", + "i_search = 3\n", + "Looking for paths with length: 3 for node FOXA1 and POU3F1\n", + "looking for paths in the network with length: 0 for node FOXA1 and CEBPB\n", + "looking for paths in the network with length: 1 for node FOXA1 and CEBPB\n", + "looking for paths in the network with length: 2 for node FOXA1 and CEBPB\n", + "looking for paths in the network with length: 3 for node FOXA1 and CEBPB\n", + "Found a path!\n", + "[['FOXA1', 'HSPA1A', 'NR3C1', 'CEBPB'], ['FOXA1', 'AR', 'NR3C1', 'CEBPB']]\n", + "looking for paths in the network with length: 0 for node GRHL1 and GRHL3\n", + "looking for paths in the network with length: 1 for node GRHL1 and GRHL3\n", + "looking for paths in the network with length: 2 for node GRHL1 and GRHL3\n", + "looking for paths in the network with length: 3 for node GRHL1 and GRHL3\n", + "looking for paths in the network with length: 4 for node GRHL1 and GRHL3\n", + "looking for paths in the network with length: 5 for node GRHL1 and GRHL3\n", + "looking for paths in the network with length: 6 for node GRHL1 and GRHL3\n", + "i_search = 3\n", + "Looking for paths with length: 0 for node GRHL1 and GRHL3\n", + "i_search = 3\n", + "Looking for paths with length: 1 for node GRHL1 and GRHL3\n", + "i_search = 3\n", + "Looking for paths with length: 2 for node GRHL1 and GRHL3\n", + "i_search = 3\n", + "Looking for paths with length: 3 for node GRHL1 and GRHL3\n", + "looking for paths in the network with length: 0 for node GRHL1 and EHF\n", + "looking for paths in the network with length: 1 for node GRHL1 and EHF\n", + "looking for paths in the network with length: 2 for node GRHL1 and EHF\n", + "looking for paths in the network with length: 3 for node GRHL1 and EHF\n", + "looking for paths in the network with length: 4 for node GRHL1 and EHF\n", + "looking for paths in the network with length: 5 for node GRHL1 and EHF\n", + "looking for paths in the network with length: 6 for node GRHL1 and EHF\n", + "i_search = 3\n", + "Looking for paths with length: 0 for node GRHL1 and EHF\n", + "i_search = 3\n", + "Looking for paths with length: 1 for node GRHL1 and EHF\n", + "i_search = 3\n", + "Looking for paths with length: 2 for node GRHL1 and EHF\n", + "i_search = 3\n", + "Looking for paths with length: 3 for node GRHL1 and EHF\n", + "looking for paths in the network with length: 0 for node GRHL1 and KLF5\n", + "looking for paths in the network with length: 1 for node GRHL1 and KLF5\n", + "looking for paths in the network with length: 2 for node GRHL1 and KLF5\n", + "looking for paths in the network with length: 3 for node GRHL1 and KLF5\n", + "looking for paths in the network with length: 4 for node GRHL1 and KLF5\n", + "looking for paths in the network with length: 5 for node GRHL1 and KLF5\n", + "looking for paths in the network with length: 6 for node GRHL1 and KLF5\n", + "i_search = 3\n", + "Looking for paths with length: 0 for node GRHL1 and KLF5\n", + "i_search = 3\n", + "Looking for paths with length: 1 for node GRHL1 and KLF5\n", + "i_search = 3\n", + "Looking for paths with length: 2 for node GRHL1 and KLF5\n", + "i_search = 3\n", + "Looking for paths with length: 3 for node GRHL1 and KLF5\n", + "looking for paths in the network with length: 0 for node GRHL1 and HOXA9\n", + "looking for paths in the network with length: 1 for node GRHL1 and HOXA9\n", + "looking for paths in the network with length: 2 for node GRHL1 and HOXA9\n", + "looking for paths in the network with length: 3 for node GRHL1 and HOXA9\n", + "looking for paths in the network with length: 4 for node GRHL1 and HOXA9\n", + "looking for paths in the network with length: 5 for node GRHL1 and HOXA9\n", + "looking for paths in the network with length: 6 for node GRHL1 and HOXA9\n", + "i_search = 3\n", + "Looking for paths with length: 0 for node GRHL1 and HOXA9\n", + "i_search = 3\n", + "Looking for paths with length: 1 for node GRHL1 and HOXA9\n", + "i_search = 3\n", + "Looking for paths with length: 2 for node GRHL1 and HOXA9\n", + "i_search = 3\n", + "Looking for paths with length: 3 for node GRHL1 and HOXA9\n", + "looking for paths in the network with length: 0 for node GRHL1 and HOXA10\n", + "looking for paths in the network with length: 1 for node GRHL1 and HOXA10\n", + "looking for paths in the network with length: 2 for node GRHL1 and HOXA10\n", + "looking for paths in the network with length: 3 for node GRHL1 and HOXA10\n", + "looking for paths in the network with length: 4 for node GRHL1 and HOXA10\n", + "looking for paths in the network with length: 5 for node GRHL1 and HOXA10\n", + "looking for paths in the network with length: 6 for node GRHL1 and HOXA10\n", + "i_search = 3\n", + "Looking for paths with length: 0 for node GRHL1 and HOXA10\n", + "i_search = 3\n", + "Looking for paths with length: 1 for node GRHL1 and HOXA10\n", + "i_search = 3\n", + "Looking for paths with length: 2 for node GRHL1 and HOXA10\n", + "i_search = 3\n", + "Looking for paths with length: 3 for node GRHL1 and HOXA10\n", + "looking for paths in the network with length: 0 for node GRHL1 and ETV4\n", + "looking for paths in the network with length: 1 for node GRHL1 and ETV4\n", + "looking for paths in the network with length: 2 for node GRHL1 and ETV4\n", + "looking for paths in the network with length: 3 for node GRHL1 and ETV4\n", + "looking for paths in the network with length: 4 for node GRHL1 and ETV4\n", + "looking for paths in the network with length: 5 for node GRHL1 and ETV4\n", + "looking for paths in the network with length: 6 for node GRHL1 and ETV4\n", + "i_search = 3\n", + "Looking for paths with length: 0 for node GRHL1 and ETV4\n", + "i_search = 3\n", + "Looking for paths with length: 1 for node GRHL1 and ETV4\n", + "i_search = 3\n", + "Looking for paths with length: 2 for node GRHL1 and ETV4\n", + "i_search = 3\n", + "Looking for paths with length: 3 for node GRHL1 and ETV4\n", + "looking for paths in the network with length: 0 for node GRHL1 and ETV5\n", + "looking for paths in the network with length: 1 for node GRHL1 and ETV5\n", + "looking for paths in the network with length: 2 for node GRHL1 and ETV5\n", + "looking for paths in the network with length: 3 for node GRHL1 and ETV5\n", + "looking for paths in the network with length: 4 for node GRHL1 and ETV5\n", + "looking for paths in the network with length: 5 for node GRHL1 and ETV5\n", + "looking for paths in the network with length: 6 for node GRHL1 and ETV5\n", + "i_search = 3\n", + "Looking for paths with length: 0 for node GRHL1 and ETV5\n", + "i_search = 3\n", + "Looking for paths with length: 1 for node GRHL1 and ETV5\n", + "i_search = 3\n", + "Looking for paths with length: 2 for node GRHL1 and ETV5\n", + "i_search = 3\n", + "Looking for paths with length: 3 for node GRHL1 and ETV5\n", + "looking for paths in the network with length: 0 for node GRHL1 and POU3F1\n", + "looking for paths in the network with length: 1 for node GRHL1 and POU3F1\n", + "looking for paths in the network with length: 2 for node GRHL1 and POU3F1\n", + "looking for paths in the network with length: 3 for node GRHL1 and POU3F1\n", + "looking for paths in the network with length: 4 for node GRHL1 and POU3F1\n", + "looking for paths in the network with length: 5 for node GRHL1 and POU3F1\n", + "looking for paths in the network with length: 6 for node GRHL1 and POU3F1\n", + "i_search = 3\n", + "Looking for paths with length: 0 for node GRHL1 and POU3F1\n", + "i_search = 3\n", + "Looking for paths with length: 1 for node GRHL1 and POU3F1\n", + "i_search = 3\n", + "Looking for paths with length: 2 for node GRHL1 and POU3F1\n", + "i_search = 3\n", + "Looking for paths with length: 3 for node GRHL1 and POU3F1\n", + "looking for paths in the network with length: 0 for node GRHL1 and CEBPB\n", + "looking for paths in the network with length: 1 for node GRHL1 and CEBPB\n", + "looking for paths in the network with length: 2 for node GRHL1 and CEBPB\n", + "looking for paths in the network with length: 3 for node GRHL1 and CEBPB\n", + "looking for paths in the network with length: 4 for node GRHL1 and CEBPB\n", + "looking for paths in the network with length: 5 for node GRHL1 and CEBPB\n", + "looking for paths in the network with length: 6 for node GRHL1 and CEBPB\n", + "i_search = 3\n", + "Looking for paths with length: 0 for node GRHL1 and CEBPB\n", + "i_search = 3\n", + "Looking for paths with length: 1 for node GRHL1 and CEBPB\n", + "i_search = 3\n", + "Looking for paths with length: 2 for node GRHL1 and CEBPB\n", + "i_search = 3\n", + "Looking for paths with length: 3 for node GRHL1 and CEBPB\n", + "looking for paths in the network with length: 0 for node GRHL3 and EHF\n", + "looking for paths in the network with length: 1 for node GRHL3 and EHF\n", + "looking for paths in the network with length: 2 for node GRHL3 and EHF\n", + "looking for paths in the network with length: 3 for node GRHL3 and EHF\n", + "looking for paths in the network with length: 4 for node GRHL3 and EHF\n", + "looking for paths in the network with length: 5 for node GRHL3 and EHF\n", + "looking for paths in the network with length: 6 for node GRHL3 and EHF\n", + "i_search = 3\n", + "Looking for paths with length: 0 for node GRHL3 and EHF\n", + "i_search = 3\n", + "Looking for paths with length: 1 for node GRHL3 and EHF\n", + "i_search = 3\n", + "Looking for paths with length: 2 for node GRHL3 and EHF\n", + "i_search = 3\n", + "Looking for paths with length: 3 for node GRHL3 and EHF\n", + "looking for paths in the network with length: 0 for node GRHL3 and KLF5\n", + "looking for paths in the network with length: 1 for node GRHL3 and KLF5\n", + "looking for paths in the network with length: 2 for node GRHL3 and KLF5\n", + "looking for paths in the network with length: 3 for node GRHL3 and KLF5\n", + "looking for paths in the network with length: 4 for node GRHL3 and KLF5\n", + "looking for paths in the network with length: 5 for node GRHL3 and KLF5\n", + "looking for paths in the network with length: 6 for node GRHL3 and KLF5\n", + "i_search = 3\n", + "Looking for paths with length: 0 for node GRHL3 and KLF5\n", + "i_search = 3\n", + "Looking for paths with length: 1 for node GRHL3 and KLF5\n", + "i_search = 3\n", + "Looking for paths with length: 2 for node GRHL3 and KLF5\n", + "i_search = 3\n", + "Looking for paths with length: 3 for node GRHL3 and KLF5\n", + "looking for paths in the network with length: 0 for node GRHL3 and HOXA9\n", + "looking for paths in the network with length: 1 for node GRHL3 and HOXA9\n", + "looking for paths in the network with length: 2 for node GRHL3 and HOXA9\n", + "looking for paths in the network with length: 3 for node GRHL3 and HOXA9\n", + "looking for paths in the network with length: 4 for node GRHL3 and HOXA9\n", + "looking for paths in the network with length: 5 for node GRHL3 and HOXA9\n", + "looking for paths in the network with length: 6 for node GRHL3 and HOXA9\n", + "i_search = 3\n", + "Looking for paths with length: 0 for node GRHL3 and HOXA9\n", + "i_search = 3\n", + "Looking for paths with length: 1 for node GRHL3 and HOXA9\n", + "i_search = 3\n", + "Looking for paths with length: 2 for node GRHL3 and HOXA9\n", + "i_search = 3\n", + "Looking for paths with length: 3 for node GRHL3 and HOXA9\n", + "looking for paths in the network with length: 0 for node GRHL3 and HOXA10\n", + "looking for paths in the network with length: 1 for node GRHL3 and HOXA10\n", + "looking for paths in the network with length: 2 for node GRHL3 and HOXA10\n", + "looking for paths in the network with length: 3 for node GRHL3 and HOXA10\n", + "looking for paths in the network with length: 4 for node GRHL3 and HOXA10\n", + "looking for paths in the network with length: 5 for node GRHL3 and HOXA10\n", + "looking for paths in the network with length: 6 for node GRHL3 and HOXA10\n", + "i_search = 3\n", + "Looking for paths with length: 0 for node GRHL3 and HOXA10\n", + "i_search = 3\n", + "Looking for paths with length: 1 for node GRHL3 and HOXA10\n", + "i_search = 3\n", + "Looking for paths with length: 2 for node GRHL3 and HOXA10\n", + "i_search = 3\n", + "Looking for paths with length: 3 for node GRHL3 and HOXA10\n", + "looking for paths in the network with length: 0 for node GRHL3 and ETV4\n", + "looking for paths in the network with length: 1 for node GRHL3 and ETV4\n", + "looking for paths in the network with length: 2 for node GRHL3 and ETV4\n", + "looking for paths in the network with length: 3 for node GRHL3 and ETV4\n", + "looking for paths in the network with length: 4 for node GRHL3 and ETV4\n", + "looking for paths in the network with length: 5 for node GRHL3 and ETV4\n", + "looking for paths in the network with length: 6 for node GRHL3 and ETV4\n", + "i_search = 3\n", + "Looking for paths with length: 0 for node GRHL3 and ETV4\n", + "i_search = 3\n", + "Looking for paths with length: 1 for node GRHL3 and ETV4\n", + "i_search = 3\n", + "Looking for paths with length: 2 for node GRHL3 and ETV4\n", + "i_search = 3\n", + "Looking for paths with length: 3 for node GRHL3 and ETV4\n", + "looking for paths in the network with length: 0 for node GRHL3 and ETV5\n", + "looking for paths in the network with length: 1 for node GRHL3 and ETV5\n", + "looking for paths in the network with length: 2 for node GRHL3 and ETV5\n", + "looking for paths in the network with length: 3 for node GRHL3 and ETV5\n", + "looking for paths in the network with length: 4 for node GRHL3 and ETV5\n", + "looking for paths in the network with length: 5 for node GRHL3 and ETV5\n", + "looking for paths in the network with length: 6 for node GRHL3 and ETV5\n", + "i_search = 3\n", + "Looking for paths with length: 0 for node GRHL3 and ETV5\n", + "i_search = 3\n", + "Looking for paths with length: 1 for node GRHL3 and ETV5\n", + "i_search = 3\n", + "Looking for paths with length: 2 for node GRHL3 and ETV5\n", + "i_search = 3\n", + "Looking for paths with length: 3 for node GRHL3 and ETV5\n", + "looking for paths in the network with length: 0 for node GRHL3 and POU3F1\n", + "looking for paths in the network with length: 1 for node GRHL3 and POU3F1\n", + "looking for paths in the network with length: 2 for node GRHL3 and POU3F1\n", + "looking for paths in the network with length: 3 for node GRHL3 and POU3F1\n", + "looking for paths in the network with length: 4 for node GRHL3 and POU3F1\n", + "looking for paths in the network with length: 5 for node GRHL3 and POU3F1\n", + "looking for paths in the network with length: 6 for node GRHL3 and POU3F1\n", + "i_search = 3\n", + "Looking for paths with length: 0 for node GRHL3 and POU3F1\n", + "i_search = 3\n", + "Looking for paths with length: 1 for node GRHL3 and POU3F1\n", + "i_search = 3\n", + "Looking for paths with length: 2 for node GRHL3 and POU3F1\n", + "i_search = 3\n", + "Looking for paths with length: 3 for node GRHL3 and POU3F1\n", + "looking for paths in the network with length: 0 for node GRHL3 and CEBPB\n", + "looking for paths in the network with length: 1 for node GRHL3 and CEBPB\n", + "looking for paths in the network with length: 2 for node GRHL3 and CEBPB\n", + "looking for paths in the network with length: 3 for node GRHL3 and CEBPB\n", + "looking for paths in the network with length: 4 for node GRHL3 and CEBPB\n", + "looking for paths in the network with length: 5 for node GRHL3 and CEBPB\n", + "looking for paths in the network with length: 6 for node GRHL3 and CEBPB\n", + "i_search = 3\n", + "Looking for paths with length: 0 for node GRHL3 and CEBPB\n", + "i_search = 3\n", + "Looking for paths with length: 1 for node GRHL3 and CEBPB\n", + "i_search = 3\n", + "Looking for paths with length: 2 for node GRHL3 and CEBPB\n", + "i_search = 3\n", + "Looking for paths with length: 3 for node GRHL3 and CEBPB\n", + "looking for paths in the network with length: 0 for node EHF and KLF5\n", + "looking for paths in the network with length: 1 for node EHF and KLF5\n", + "looking for paths in the network with length: 2 for node EHF and KLF5\n", + "looking for paths in the network with length: 3 for node EHF and KLF5\n", + "looking for paths in the network with length: 4 for node EHF and KLF5\n", + "looking for paths in the network with length: 5 for node EHF and KLF5\n", + "looking for paths in the network with length: 6 for node EHF and KLF5\n", + "i_search = 3\n", + "Looking for paths with length: 0 for node EHF and KLF5\n", + "i_search = 3\n", + "Looking for paths with length: 1 for node EHF and KLF5\n", + "i_search = 3\n", + "Looking for paths with length: 2 for node EHF and KLF5\n", + "i_search = 3\n", + "Looking for paths with length: 3 for node EHF and KLF5\n", + "looking for paths in the network with length: 0 for node EHF and HOXA9\n", + "looking for paths in the network with length: 1 for node EHF and HOXA9\n", + "looking for paths in the network with length: 2 for node EHF and HOXA9\n", + "looking for paths in the network with length: 3 for node EHF and HOXA9\n", + "looking for paths in the network with length: 4 for node EHF and HOXA9\n", + "looking for paths in the network with length: 5 for node EHF and HOXA9\n", + "looking for paths in the network with length: 6 for node EHF and HOXA9\n", + "i_search = 3\n", + "Looking for paths with length: 0 for node EHF and HOXA9\n", + "i_search = 3\n", + "Looking for paths with length: 1 for node EHF and HOXA9\n", + "i_search = 3\n", + "Looking for paths with length: 2 for node EHF and HOXA9\n", + "i_search = 3\n", + "Looking for paths with length: 3 for node EHF and HOXA9\n", + "looking for paths in the network with length: 0 for node EHF and HOXA10\n", + "looking for paths in the network with length: 1 for node EHF and HOXA10\n", + "looking for paths in the network with length: 2 for node EHF and HOXA10\n", + "looking for paths in the network with length: 3 for node EHF and HOXA10\n", + "looking for paths in the network with length: 4 for node EHF and HOXA10\n", + "looking for paths in the network with length: 5 for node EHF and HOXA10\n", + "looking for paths in the network with length: 6 for node EHF and HOXA10\n", + "i_search = 3\n", + "Looking for paths with length: 0 for node EHF and HOXA10\n", + "i_search = 3\n", + "Looking for paths with length: 1 for node EHF and HOXA10\n", + "i_search = 3\n", + "Looking for paths with length: 2 for node EHF and HOXA10\n", + "i_search = 3\n", + "Looking for paths with length: 3 for node EHF and HOXA10\n", + "looking for paths in the network with length: 0 for node EHF and ETV4\n", + "looking for paths in the network with length: 1 for node EHF and ETV4\n", + "looking for paths in the network with length: 2 for node EHF and ETV4\n", + "looking for paths in the network with length: 3 for node EHF and ETV4\n", + "looking for paths in the network with length: 4 for node EHF and ETV4\n", + "looking for paths in the network with length: 5 for node EHF and ETV4\n", + "looking for paths in the network with length: 6 for node EHF and ETV4\n", + "i_search = 3\n", + "Looking for paths with length: 0 for node EHF and ETV4\n", + "i_search = 3\n", + "Looking for paths with length: 1 for node EHF and ETV4\n", + "i_search = 3\n", + "Looking for paths with length: 2 for node EHF and ETV4\n", + "i_search = 3\n", + "Looking for paths with length: 3 for node EHF and ETV4\n", + "looking for paths in the network with length: 0 for node EHF and ETV5\n", + "looking for paths in the network with length: 1 for node EHF and ETV5\n", + "looking for paths in the network with length: 2 for node EHF and ETV5\n", + "looking for paths in the network with length: 3 for node EHF and ETV5\n", + "looking for paths in the network with length: 4 for node EHF and ETV5\n", + "looking for paths in the network with length: 5 for node EHF and ETV5\n", + "looking for paths in the network with length: 6 for node EHF and ETV5\n", + "i_search = 3\n", + "Looking for paths with length: 0 for node EHF and ETV5\n", + "i_search = 3\n", + "Looking for paths with length: 1 for node EHF and ETV5\n", + "i_search = 3\n", + "Looking for paths with length: 2 for node EHF and ETV5\n", + "i_search = 3\n", + "Looking for paths with length: 3 for node EHF and ETV5\n", + "looking for paths in the network with length: 0 for node EHF and POU3F1\n", + "looking for paths in the network with length: 1 for node EHF and POU3F1\n", + "looking for paths in the network with length: 2 for node EHF and POU3F1\n", + "looking for paths in the network with length: 3 for node EHF and POU3F1\n", + "looking for paths in the network with length: 4 for node EHF and POU3F1\n", + "looking for paths in the network with length: 5 for node EHF and POU3F1\n", + "looking for paths in the network with length: 6 for node EHF and POU3F1\n", + "i_search = 3\n", + "Looking for paths with length: 0 for node EHF and POU3F1\n", + "i_search = 3\n", + "Looking for paths with length: 1 for node EHF and POU3F1\n", + "i_search = 3\n", + "Looking for paths with length: 2 for node EHF and POU3F1\n", + "i_search = 3\n", + "Looking for paths with length: 3 for node EHF and POU3F1\n", + "looking for paths in the network with length: 0 for node EHF and CEBPB\n", + "looking for paths in the network with length: 1 for node EHF and CEBPB\n", + "looking for paths in the network with length: 2 for node EHF and CEBPB\n", + "looking for paths in the network with length: 3 for node EHF and CEBPB\n", + "looking for paths in the network with length: 4 for node EHF and CEBPB\n", + "looking for paths in the network with length: 5 for node EHF and CEBPB\n", + "looking for paths in the network with length: 6 for node EHF and CEBPB\n", + "i_search = 3\n", + "Looking for paths with length: 0 for node EHF and CEBPB\n", + "i_search = 3\n", + "Looking for paths with length: 1 for node EHF and CEBPB\n", + "i_search = 3\n", + "Looking for paths with length: 2 for node EHF and CEBPB\n", + "i_search = 3\n", + "Looking for paths with length: 3 for node EHF and CEBPB\n", + "looking for paths in the network with length: 0 for node KLF5 and HOXA9\n", + "looking for paths in the network with length: 1 for node KLF5 and HOXA9\n", + "looking for paths in the network with length: 2 for node KLF5 and HOXA9\n", + "looking for paths in the network with length: 3 for node KLF5 and HOXA9\n", + "looking for paths in the network with length: 4 for node KLF5 and HOXA9\n", + "looking for paths in the network with length: 5 for node KLF5 and HOXA9\n", + "looking for paths in the network with length: 6 for node KLF5 and HOXA9\n", + "i_search = 3\n", + "Looking for paths with length: 0 for node KLF5 and HOXA9\n", + "i_search = 3\n", + "Looking for paths with length: 1 for node KLF5 and HOXA9\n", + "i_search = 3\n", + "Looking for paths with length: 2 for node KLF5 and HOXA9\n", + "i_search = 3\n", + "Looking for paths with length: 3 for node KLF5 and HOXA9\n", + "looking for paths in the network with length: 0 for node KLF5 and HOXA10\n", + "looking for paths in the network with length: 1 for node KLF5 and HOXA10\n", + "looking for paths in the network with length: 2 for node KLF5 and HOXA10\n", + "looking for paths in the network with length: 3 for node KLF5 and HOXA10\n", + "looking for paths in the network with length: 4 for node KLF5 and HOXA10\n", + "looking for paths in the network with length: 5 for node KLF5 and HOXA10\n", + "looking for paths in the network with length: 6 for node KLF5 and HOXA10\n", + "i_search = 3\n", + "Looking for paths with length: 0 for node KLF5 and HOXA10\n", + "i_search = 3\n", + "Looking for paths with length: 1 for node KLF5 and HOXA10\n", + "i_search = 3\n", + "Looking for paths with length: 2 for node KLF5 and HOXA10\n", + "i_search = 3\n", + "Looking for paths with length: 3 for node KLF5 and HOXA10\n", + "looking for paths in the network with length: 0 for node KLF5 and ETV4\n", + "looking for paths in the network with length: 1 for node KLF5 and ETV4\n", + "looking for paths in the network with length: 2 for node KLF5 and ETV4\n", + "looking for paths in the network with length: 3 for node KLF5 and ETV4\n", + "looking for paths in the network with length: 4 for node KLF5 and ETV4\n", + "looking for paths in the network with length: 5 for node KLF5 and ETV4\n", + "looking for paths in the network with length: 6 for node KLF5 and ETV4\n", + "i_search = 3\n", + "Looking for paths with length: 0 for node KLF5 and ETV4\n", + "i_search = 3\n", + "Looking for paths with length: 1 for node KLF5 and ETV4\n", + "i_search = 3\n", + "Looking for paths with length: 2 for node KLF5 and ETV4\n", + "i_search = 3\n", + "Looking for paths with length: 3 for node KLF5 and ETV4\n", + "looking for paths in the network with length: 0 for node KLF5 and ETV5\n", + "looking for paths in the network with length: 1 for node KLF5 and ETV5\n", + "looking for paths in the network with length: 2 for node KLF5 and ETV5\n", + "looking for paths in the network with length: 3 for node KLF5 and ETV5\n", + "looking for paths in the network with length: 4 for node KLF5 and ETV5\n", + "looking for paths in the network with length: 5 for node KLF5 and ETV5\n", + "looking for paths in the network with length: 6 for node KLF5 and ETV5\n", + "i_search = 3\n", + "Looking for paths with length: 0 for node KLF5 and ETV5\n", + "i_search = 3\n", + "Looking for paths with length: 1 for node KLF5 and ETV5\n", + "i_search = 3\n", + "Looking for paths with length: 2 for node KLF5 and ETV5\n", + "i_search = 3\n", + "Looking for paths with length: 3 for node KLF5 and ETV5\n", + "looking for paths in the network with length: 0 for node KLF5 and POU3F1\n", + "looking for paths in the network with length: 1 for node KLF5 and POU3F1\n", + "looking for paths in the network with length: 2 for node KLF5 and POU3F1\n", + "looking for paths in the network with length: 3 for node KLF5 and POU3F1\n", + "looking for paths in the network with length: 4 for node KLF5 and POU3F1\n", + "looking for paths in the network with length: 5 for node KLF5 and POU3F1\n", + "looking for paths in the network with length: 6 for node KLF5 and POU3F1\n", + "i_search = 3\n", + "Looking for paths with length: 0 for node KLF5 and POU3F1\n", + "i_search = 3\n", + "Looking for paths with length: 1 for node KLF5 and POU3F1\n", + "i_search = 3\n", + "Looking for paths with length: 2 for node KLF5 and POU3F1\n", + "i_search = 3\n", + "Looking for paths with length: 3 for node KLF5 and POU3F1\n", + "looking for paths in the network with length: 0 for node KLF5 and CEBPB\n", + "looking for paths in the network with length: 1 for node KLF5 and CEBPB\n", + "Found a path!\n", + "[['KLF5', 'CEBPB']]\n", + "looking for paths in the network with length: 0 for node HOXA9 and HOXA10\n", + "looking for paths in the network with length: 1 for node HOXA9 and HOXA10\n", + "looking for paths in the network with length: 2 for node HOXA9 and HOXA10\n", + "looking for paths in the network with length: 3 for node HOXA9 and HOXA10\n", + "looking for paths in the network with length: 4 for node HOXA9 and HOXA10\n", + "looking for paths in the network with length: 5 for node HOXA9 and HOXA10\n", + "looking for paths in the network with length: 6 for node HOXA9 and HOXA10\n", + "i_search = 3\n", + "Looking for paths with length: 0 for node HOXA9 and HOXA10\n", + "i_search = 3\n", + "Looking for paths with length: 1 for node HOXA9 and HOXA10\n", + "i_search = 3\n", + "Looking for paths with length: 2 for node HOXA9 and HOXA10\n", + "i_search = 3\n", + "Looking for paths with length: 3 for node HOXA9 and HOXA10\n", + "looking for paths in the network with length: 0 for node HOXA9 and ETV4\n", + "looking for paths in the network with length: 1 for node HOXA9 and ETV4\n", + "looking for paths in the network with length: 2 for node HOXA9 and ETV4\n", + "looking for paths in the network with length: 3 for node HOXA9 and ETV4\n", + "looking for paths in the network with length: 4 for node HOXA9 and ETV4\n", + "looking for paths in the network with length: 5 for node HOXA9 and ETV4\n", + "looking for paths in the network with length: 6 for node HOXA9 and ETV4\n", + "i_search = 3\n", + "Looking for paths with length: 0 for node HOXA9 and ETV4\n", + "i_search = 3\n", + "Looking for paths with length: 1 for node HOXA9 and ETV4\n", + "i_search = 3\n", + "Looking for paths with length: 2 for node HOXA9 and ETV4\n", + "i_search = 3\n", + "Looking for paths with length: 3 for node HOXA9 and ETV4\n", + "looking for paths in the network with length: 0 for node HOXA9 and ETV5\n", + "looking for paths in the network with length: 1 for node HOXA9 and ETV5\n", + "looking for paths in the network with length: 2 for node HOXA9 and ETV5\n", + "looking for paths in the network with length: 3 for node HOXA9 and ETV5\n", + "looking for paths in the network with length: 4 for node HOXA9 and ETV5\n", + "looking for paths in the network with length: 5 for node HOXA9 and ETV5\n", + "looking for paths in the network with length: 6 for node HOXA9 and ETV5\n", + "i_search = 3\n", + "Looking for paths with length: 0 for node HOXA9 and ETV5\n", + "i_search = 3\n", + "Looking for paths with length: 1 for node HOXA9 and ETV5\n", + "i_search = 3\n", + "Looking for paths with length: 2 for node HOXA9 and ETV5\n", + "i_search = 3\n", + "Looking for paths with length: 3 for node HOXA9 and ETV5\n", + "looking for paths in the network with length: 0 for node HOXA9 and POU3F1\n", + "looking for paths in the network with length: 1 for node HOXA9 and POU3F1\n", + "looking for paths in the network with length: 2 for node HOXA9 and POU3F1\n", + "looking for paths in the network with length: 3 for node HOXA9 and POU3F1\n", + "looking for paths in the network with length: 4 for node HOXA9 and POU3F1\n", + "looking for paths in the network with length: 5 for node HOXA9 and POU3F1\n", + "looking for paths in the network with length: 6 for node HOXA9 and POU3F1\n", + "i_search = 3\n", + "Looking for paths with length: 0 for node HOXA9 and POU3F1\n", + "i_search = 3\n", + "Looking for paths with length: 1 for node HOXA9 and POU3F1\n", + "i_search = 3\n", + "Looking for paths with length: 2 for node HOXA9 and POU3F1\n", + "i_search = 3\n", + "Looking for paths with length: 3 for node HOXA9 and POU3F1\n", + "looking for paths in the network with length: 0 for node HOXA9 and CEBPB\n", + "looking for paths in the network with length: 1 for node HOXA9 and CEBPB\n", + "looking for paths in the network with length: 2 for node HOXA9 and CEBPB\n", + "looking for paths in the network with length: 3 for node HOXA9 and CEBPB\n", + "looking for paths in the network with length: 4 for node HOXA9 and CEBPB\n", + "looking for paths in the network with length: 5 for node HOXA9 and CEBPB\n", + "looking for paths in the network with length: 6 for node HOXA9 and CEBPB\n", + "i_search = 3\n", + "Looking for paths with length: 0 for node HOXA9 and CEBPB\n", + "i_search = 3\n", + "Looking for paths with length: 1 for node HOXA9 and CEBPB\n", + "i_search = 3\n", + "Looking for paths with length: 2 for node HOXA9 and CEBPB\n", + "i_search = 3\n", + "Looking for paths with length: 3 for node HOXA9 and CEBPB\n", + "[['HOXA9', 'PIM1', 'FLT3', 'CEBPB']]\n", + "P31269 P11309\n", + "P11309 P36888\n", + "P36888 P17676\n", + "P55317 P0DMV8\n", + "P55317 P10275\n", + "P55317 O00712\n", + "P17676 Q13887\n", + "P04150 Q13887\n", + "Q15910 P31269\n", + "P31269 P11309\n", + "Q15910 P31260\n", + "O00712 P41161\n", + "P04150 P17676\n", + "P36888 P17676\n", + "P0DMV8 P04150\n", + "P04150 P10275\n", + "P10275 P04150\n", + "Q15910 P10275\n", + "O00712 Q15910\n", + "P11309 P36888\n", + "P36888 P11309\n", + "looking for paths in the network with length: 0 for node HOXA10 and ETV4\n", + "looking for paths in the network with length: 1 for node HOXA10 and ETV4\n", + "looking for paths in the network with length: 2 for node HOXA10 and ETV4\n", + "looking for paths in the network with length: 3 for node HOXA10 and ETV4\n", + "looking for paths in the network with length: 4 for node HOXA10 and ETV4\n", + "looking for paths in the network with length: 5 for node HOXA10 and ETV4\n", + "looking for paths in the network with length: 6 for node HOXA10 and ETV4\n", + "i_search = 3\n", + "Looking for paths with length: 0 for node HOXA10 and ETV4\n", + "i_search = 3\n", + "Looking for paths with length: 1 for node HOXA10 and ETV4\n", + "i_search = 3\n", + "Looking for paths with length: 2 for node HOXA10 and ETV4\n", + "i_search = 3\n", + "Looking for paths with length: 3 for node HOXA10 and ETV4\n", + "looking for paths in the network with length: 0 for node HOXA10 and ETV5\n", + "looking for paths in the network with length: 1 for node HOXA10 and ETV5\n", + "looking for paths in the network with length: 2 for node HOXA10 and ETV5\n", + "looking for paths in the network with length: 3 for node HOXA10 and ETV5\n", + "looking for paths in the network with length: 4 for node HOXA10 and ETV5\n", + "looking for paths in the network with length: 5 for node HOXA10 and ETV5\n", + "looking for paths in the network with length: 6 for node HOXA10 and ETV5\n", + "i_search = 3\n", + "Looking for paths with length: 0 for node HOXA10 and ETV5\n", + "i_search = 3\n", + "Looking for paths with length: 1 for node HOXA10 and ETV5\n", + "i_search = 3\n", + "Looking for paths with length: 2 for node HOXA10 and ETV5\n", + "i_search = 3\n", + "Looking for paths with length: 3 for node HOXA10 and ETV5\n", + "looking for paths in the network with length: 0 for node HOXA10 and POU3F1\n", + "looking for paths in the network with length: 1 for node HOXA10 and POU3F1\n", + "looking for paths in the network with length: 2 for node HOXA10 and POU3F1\n", + "looking for paths in the network with length: 3 for node HOXA10 and POU3F1\n", + "looking for paths in the network with length: 4 for node HOXA10 and POU3F1\n", + "looking for paths in the network with length: 5 for node HOXA10 and POU3F1\n", + "looking for paths in the network with length: 6 for node HOXA10 and POU3F1\n", + "i_search = 3\n", + "Looking for paths with length: 0 for node HOXA10 and POU3F1\n", + "i_search = 3\n", + "Looking for paths with length: 1 for node HOXA10 and POU3F1\n", + "i_search = 3\n", + "Looking for paths with length: 2 for node HOXA10 and POU3F1\n", + "i_search = 3\n", + "Looking for paths with length: 3 for node HOXA10 and POU3F1\n", + "looking for paths in the network with length: 0 for node HOXA10 and CEBPB\n", + "looking for paths in the network with length: 1 for node HOXA10 and CEBPB\n", + "looking for paths in the network with length: 2 for node HOXA10 and CEBPB\n", + "looking for paths in the network with length: 3 for node HOXA10 and CEBPB\n", + "looking for paths in the network with length: 4 for node HOXA10 and CEBPB\n", + "looking for paths in the network with length: 5 for node HOXA10 and CEBPB\n", + "looking for paths in the network with length: 6 for node HOXA10 and CEBPB\n", + "i_search = 3\n", + "Looking for paths with length: 0 for node HOXA10 and CEBPB\n", + "i_search = 3\n", + "Looking for paths with length: 1 for node HOXA10 and CEBPB\n", + "i_search = 3\n", + "Looking for paths with length: 2 for node HOXA10 and CEBPB\n", + "i_search = 3\n", + "Looking for paths with length: 3 for node HOXA10 and CEBPB\n", + "looking for paths in the network with length: 0 for node ETV4 and ETV5\n", + "looking for paths in the network with length: 1 for node ETV4 and ETV5\n", + "looking for paths in the network with length: 2 for node ETV4 and ETV5\n", + "looking for paths in the network with length: 3 for node ETV4 and ETV5\n", + "looking for paths in the network with length: 4 for node ETV4 and ETV5\n", + "looking for paths in the network with length: 5 for node ETV4 and ETV5\n", + "looking for paths in the network with length: 6 for node ETV4 and ETV5\n", + "i_search = 3\n", + "Looking for paths with length: 0 for node ETV4 and ETV5\n", + "i_search = 3\n", + "Looking for paths with length: 1 for node ETV4 and ETV5\n", + "i_search = 3\n", + "Looking for paths with length: 2 for node ETV4 and ETV5\n", + "i_search = 3\n", + "Looking for paths with length: 3 for node ETV4 and ETV5\n", + "looking for paths in the network with length: 0 for node ETV4 and POU3F1\n", + "looking for paths in the network with length: 1 for node ETV4 and POU3F1\n", + "looking for paths in the network with length: 2 for node ETV4 and POU3F1\n", + "looking for paths in the network with length: 3 for node ETV4 and POU3F1\n", + "looking for paths in the network with length: 4 for node ETV4 and POU3F1\n", + "looking for paths in the network with length: 5 for node ETV4 and POU3F1\n", + "looking for paths in the network with length: 6 for node ETV4 and POU3F1\n", + "i_search = 3\n", + "Looking for paths with length: 0 for node ETV4 and POU3F1\n", + "i_search = 3\n", + "Looking for paths with length: 1 for node ETV4 and POU3F1\n", + "i_search = 3\n", + "Looking for paths with length: 2 for node ETV4 and POU3F1\n", + "i_search = 3\n", + "Looking for paths with length: 3 for node ETV4 and POU3F1\n", + "looking for paths in the network with length: 0 for node ETV4 and CEBPB\n", + "looking for paths in the network with length: 1 for node ETV4 and CEBPB\n", + "looking for paths in the network with length: 2 for node ETV4 and CEBPB\n", + "looking for paths in the network with length: 3 for node ETV4 and CEBPB\n", + "looking for paths in the network with length: 4 for node ETV4 and CEBPB\n", + "looking for paths in the network with length: 5 for node ETV4 and CEBPB\n", + "looking for paths in the network with length: 6 for node ETV4 and CEBPB\n", + "i_search = 3\n", + "Looking for paths with length: 0 for node ETV4 and CEBPB\n", + "i_search = 3\n", + "Looking for paths with length: 1 for node ETV4 and CEBPB\n", + "i_search = 3\n", + "Looking for paths with length: 2 for node ETV4 and CEBPB\n", + "i_search = 3\n", + "Looking for paths with length: 3 for node ETV4 and CEBPB\n", + "looking for paths in the network with length: 0 for node ETV5 and POU3F1\n", + "looking for paths in the network with length: 1 for node ETV5 and POU3F1\n", + "looking for paths in the network with length: 2 for node ETV5 and POU3F1\n", + "looking for paths in the network with length: 3 for node ETV5 and POU3F1\n", + "looking for paths in the network with length: 4 for node ETV5 and POU3F1\n", + "looking for paths in the network with length: 5 for node ETV5 and POU3F1\n", + "looking for paths in the network with length: 6 for node ETV5 and POU3F1\n", + "i_search = 3\n", + "Looking for paths with length: 0 for node ETV5 and POU3F1\n", + "i_search = 3\n", + "Looking for paths with length: 1 for node ETV5 and POU3F1\n", + "i_search = 3\n", + "Looking for paths with length: 2 for node ETV5 and POU3F1\n", + "i_search = 3\n", + "Looking for paths with length: 3 for node ETV5 and POU3F1\n", + "looking for paths in the network with length: 0 for node ETV5 and CEBPB\n", + "looking for paths in the network with length: 1 for node ETV5 and CEBPB\n", + "looking for paths in the network with length: 2 for node ETV5 and CEBPB\n", + "looking for paths in the network with length: 3 for node ETV5 and CEBPB\n", + "looking for paths in the network with length: 4 for node ETV5 and CEBPB\n", + "looking for paths in the network with length: 5 for node ETV5 and CEBPB\n", + "looking for paths in the network with length: 6 for node ETV5 and CEBPB\n", + "i_search = 3\n", + "Looking for paths with length: 0 for node ETV5 and CEBPB\n", + "i_search = 3\n", + "Looking for paths with length: 1 for node ETV5 and CEBPB\n", + "i_search = 3\n", + "Looking for paths with length: 2 for node ETV5 and CEBPB\n", + "i_search = 3\n", + "Looking for paths with length: 3 for node ETV5 and CEBPB\n", + "looking for paths in the network with length: 0 for node POU3F1 and CEBPB\n", + "looking for paths in the network with length: 1 for node POU3F1 and CEBPB\n", + "looking for paths in the network with length: 2 for node POU3F1 and CEBPB\n", + "looking for paths in the network with length: 3 for node POU3F1 and CEBPB\n", + "looking for paths in the network with length: 4 for node POU3F1 and CEBPB\n", + "looking for paths in the network with length: 5 for node POU3F1 and CEBPB\n", + "looking for paths in the network with length: 6 for node POU3F1 and CEBPB\n", + "i_search = 3\n", + "Looking for paths with length: 0 for node POU3F1 and CEBPB\n", + "i_search = 3\n", + "Looking for paths with length: 1 for node POU3F1 and CEBPB\n", + "i_search = 3\n", + "Looking for paths with length: 2 for node POU3F1 and CEBPB\n", + "i_search = 3\n", + "Looking for paths with length: 3 for node POU3F1 and CEBPB\n", + "CPU times: user 8.91 s, sys: 36 ms, total: 8.95 s\n", + "Wall time: 8.91 s\n" + ] + } + ], + "source": [ + "%%time\n", + "new_net1.complete_connection(mode=\"ALL\", maxlen=6, k_mean=\"tight\", only_signed=True,\n", + " connect_node_when_first_introduced=True) # here, consensus_only is missing, in this way it is automatically False" + ] + }, + { + "cell_type": "markdown", + "id": "64b445e7-2e45-40ee-9ee9-268965b4d55b", + "metadata": {}, + "source": [ + "## SIGNOR uses has different identifiers for complexes, protein family, phenotype, etc.\n", + "## It is possible that the network contains nodes names like \"Signor_pf32\" or something like this... This is not yet translated, but if you are interested in what those nodes consist of, you can use download their vocabulary for the entities: https://signor.uniroma2.it/downloads.php\n", + "## Maybe we are going to integrate this too... " + ] + }, + { + "cell_type": "markdown", + "id": "6b54c437", + "metadata": {}, + "source": [ + "### Finally we can export the network in bnet format with some basic logical equations or in sif format for Cytoscape visualization" + ] + }, + { + "cell_type": "code", + "execution_count": 13, + "id": "547e4090", + "metadata": {}, + "outputs": [], + "source": [ + "from omniflow_project._outputs.exports import Exports" + ] + }, + { + "cell_type": "code", + "execution_count": 14, + "id": "6fd81835", + "metadata": {}, + "outputs": [], + "source": [ + "export = Exports(new_net1)" + ] + }, + { + "cell_type": "code", + "execution_count": 15, + "id": "a408094f", + "metadata": {}, + "outputs": [], + "source": [ + "export.export_bnet()\n", + "export.export_sif()" + ] + }, + { + "cell_type": "markdown", + "id": "8ed135d3-9f71-4cec-9381-96c63fba766e", + "metadata": {}, + "source": [ + "### Gene Ontology\n", + "## A new feature of Omniflow. Now, the user can connect the nodes of the Network with markers of a certain phenotype, from Gene Ontology. " + ] + }, + { + "cell_type": "code", + "execution_count": 10, + "id": "fa499a38-c22a-4a0e-b1d4-3ffb10e4a370", + "metadata": {}, + "outputs": [ + { + "name": "stdout", + "output_type": "stream", + "text": [ + "Start requesting genes from Gene Ontology\n", + "Fetching from: https://golr-aux.geneontology.io/solr/select?defType=edismax&qt=standard&indent=on&wt=csv&rows=100000&start=0&fl=bioentity_label&facet=true&facet.mincount=1&facet.sort=count&json.nl=arrarr&facet.limit=25&hl=true&hl.simple.pre=%3Cem%20class=%22hilite%22%3E&hl.snippets=1000&csv.encapsulator=&csv.separator=%09&csv.header=false&csv.mv.separator=%7C&fq=document_category:%22annotation%22&fq=isa_partof_closure:%22GO:0097194%22&fq=taxon_subset_closure_label:%22Homo%20sapiens%22&fq=type:%22protein%22&fq=annotation_class_label:%22execution%20phase%20of%20apoptosis%22&facet.field=aspect&facet.field=taxon_subset_closure_label&facet.field=type&facet.field=evidence_subset_closure_label&facet.field=regulates_closure_label&facet.field=isa_partof_closure_label&facet.field=annotation_class_label&facet.field=qualifier&facet.field=annotation_extension_class_closure_label&facet.field=assigned_by&facet.field=panther_family_label&q=*:*\n", + "Done\n", + "Starting connecting network's nodes to: ['AIFM3', 'CASP7', 'MADD', 'CASP3', 'CASP8', 'CASP5', 'BNIP1', 'CIDEC', 'COLEC11', 'HTRA2', 'CASP12', 'TAOK1', 'BBC3', 'CFLAR', 'CIDEB', 'NFKBIZ', 'CASP6', 'STK24', 'CASP4', 'AKT1', 'NPR2', 'CASP2', 'CECR2']\n", + "Q01094 Q96PG8\n", + "P28482 Q14790\n", + "P31749 O15519\n", + "P31749 O43464\n", + "P06493 Q14790\n", + "P62136 P42575\n", + "SIGNOR-PF54 P42575\n", + "Q13315 Q7L7X3\n", + "P68400 P42575\n", + "Q16539 O15519\n", + "Q16539 P42574\n", + "Q16539 Q14790\n", + "P27361 Q14790\n", + "SIGNOR-PF1 Q14790\n", + "CPU times: user 1.17 s, sys: 1.02 ms, total: 1.17 s\n", + "Wall time: 1.98 s\n" + ] + } + ], + "source": [ + "%%time\n", + "new_net1.connect_genes_to_phenotype(id_accession=\"GO:0097194\", phenotype=\"execution phase of apoptosis\", only_signed=True, compress=True, maxlen=1)" + ] + }, + { + "cell_type": "markdown", + "id": "48bf53a4", + "metadata": {}, + "source": [ + "# TO DO:\n", + "\n", + "- method to print sif file with reference for each interaction (easy task)\n", + "- more utility functions (???)\n", + "- create function to look for common upstream for group of nodes" + ] + }, + { + "cell_type": "code", + "execution_count": null, + "id": "33300268-bcf6-442b-97be-c7718922a939", + "metadata": {}, + "outputs": [], + "source": [] + } + ], + "metadata": { + "kernelspec": { + "display_name": "Python 3 (ipykernel)", + "language": "python", + "name": "python3" + }, + "language_info": { + "codemirror_mode": { + "name": "ipython", + "version": 3 + }, + "file_extension": ".py", + "mimetype": "text/x-python", + "name": "python", + "nbconvert_exporter": "python", + "pygments_lexer": "ipython3", + "version": "3.10.13" + } + }, + "nbformat": 4, + "nbformat_minor": 5 +} From 14d3adea17edb55063b9a4a90a4930de6dfede72 Mon Sep 17 00:00:00 2001 From: Eirinits Date: Thu, 4 Apr 2024 11:51:59 +0200 Subject: [PATCH 08/10] Tutorial: Tissue mapping --- notebooks/tissue_mapping.ipynb | 986 +++++++++++++++++++++++++++++++++ 1 file changed, 986 insertions(+) create mode 100644 notebooks/tissue_mapping.ipynb diff --git a/notebooks/tissue_mapping.ipynb b/notebooks/tissue_mapping.ipynb new file mode 100644 index 0000000..0b5a01c --- /dev/null +++ b/notebooks/tissue_mapping.ipynb @@ -0,0 +1,986 @@ +{ + "cells": [ + { + "cell_type": "markdown", + "id": "55b5595c-fec9-41c3-b756-b95cd0c52048", + "metadata": {}, + "source": [ + "## Map tissue expression\n", + "\n", + "This notebook explores how you can explore whether the nodes in your network are expressed in a tissue of interest. The annotations are accessed from the Annotation object of Omnipath, and are based on expression data from the Human Protein Atlas." + ] + }, + { + "cell_type": "code", + "execution_count": 2, + "id": "3c317de8", + "metadata": {}, + "outputs": [ + { + "name": "stderr", + "output_type": "stream", + "text": [ + "/home/eirini/anaconda3/envs/omniflow_env/lib/python3.10/site-packages/tqdm/auto.py:21: TqdmWarning: IProgress not found. Please update jupyter and ipywidgets. See https://ipywidgets.readthedocs.io/en/stable/user_install.html\n", + " from .autonotebook import tqdm as notebook_tqdm\n" + ] + }, + { + "ename": "ModuleNotFoundError", + "evalue": "No module named 'omniflow_project._annotations'", + "output_type": "error", + "traceback": [ + "\u001b[0;31m---------------------------------------------------------------------------\u001b[0m", + "\u001b[0;31mModuleNotFoundError\u001b[0m Traceback (most recent call last)", + "File \u001b[0;32m:4\u001b[0m\n", + "\u001b[0;31mModuleNotFoundError\u001b[0m: No module named 'omniflow_project._annotations'" + ] + } + ], + "source": [ + "%%time\n", + "from omniflow_project.core.network import Network\n", + "from omniflow_project._visual.visualize_network import NetworkVisualizer\n", + "from omniflow_project._inputs.resources import Resources\n", + "from omniflow_project._annotations.gene_ontology import Ontology\n", + "import omnipath as op" + ] + }, + { + "cell_type": "markdown", + "id": "2910c871-fdfc-4d20-b76f-af213f06a3f0", + "metadata": {}, + "source": [ + "### 1. Import genes as network nodes" + ] + }, + { + "cell_type": "code", + "execution_count": 3, + "id": "79c09e13", + "metadata": {}, + "outputs": [], + "source": [ + "genes = [\"SRC\", \"NOTCH1\", \"FAK\", \"CDH1\", \"CDH2\", \"VIM\", \"MAP4K4\", \"LATS1\", \"LATS2\", \"PTK2B\"]" + ] + }, + { + "cell_type": "code", + "execution_count": 3, + "id": "fcf68a99-8454-41e3-8816-c3f976d04c0b", + "metadata": {}, + "outputs": [ + { + "name": "stdout", + "output_type": "stream", + "text": [ + "Loading deafault omnipath all interactions\n" + ] + } + ], + "source": [ + "new_net1 = Network(genes)" + ] + }, + { + "cell_type": "code", + "execution_count": 4, + "id": "fad00bec-ba72-4943-bf1e-9c60f58f17a2", + "metadata": {}, + "outputs": [ + { + "ename": "NameError", + "evalue": "name 'new_net1' is not defined", + "output_type": "error", + "traceback": [ + "\u001b[0;31m---------------------------------------------------------------------------\u001b[0m", + "\u001b[0;31mNameError\u001b[0m Traceback (most recent call last)", + "Cell \u001b[0;32mIn[4], line 2\u001b[0m\n\u001b[1;32m 1\u001b[0m \u001b[38;5;66;03m#Print node dataframe\u001b[39;00m\n\u001b[0;32m----> 2\u001b[0m \u001b[43mnew_net1\u001b[49m\u001b[38;5;241m.\u001b[39mnodes\n", + "\u001b[0;31mNameError\u001b[0m: name 'new_net1' is not defined" + ] + } + ], + "source": [ + "#Print node dataframe\n", + "new_net1.nodes" + ] + }, + { + "cell_type": "markdown", + "id": "3e9006ec-00d2-453d-8b8f-e939938e9068", + "metadata": {}, + "source": [ + "### 2. Check if the genes are annotated in the tissue of interest (e.g., in colorectal cancer)" + ] + }, + { + "cell_type": "code", + "execution_count": 13, + "id": "9540f33d-68f8-4c98-b68e-3e3d1497467e", + "metadata": {}, + "outputs": [ + { + "name": "stdout", + "output_type": "stream", + "text": [ + " Genesymbol in_tissue\n", + "0 SRC True\n", + "1 NOTCH1 True\n", + "2 PTK2 True\n", + "3 CDH1 True\n", + "4 CDH2 True\n", + "5 VIM True\n", + "6 MAP4K4 True\n", + "7 LATS1 True\n", + "8 LATS2 True\n", + "9 PTK2B True\n", + "10 CTNNB1 True\n", + "11 DAB1 True\n", + "12 MET True\n", + "13 PRKD1 True\n", + "14 CTNND1 True\n", + "15 PAK2 True\n", + "16 MAPK8 True\n", + "17 MAP3K7 True\n", + "18 MAP3K1 True\n", + "19 RAF1 True\n", + "20 STK3 True\n", + "21 STK4 True\n", + "22 NF2 True\n", + "23 SMAD3 True\n", + "24 BCAR1 True\n", + "25 LCK True\n", + "26 PTPRH True\n", + "27 WWTR1 True\n", + "28 YAP1 True\n", + "29 RUNX2 True\n", + "30 EGFR True\n" + ] + } + ], + "source": [ + "annot = Ontology()\n", + "results_df = annot.check_tissue_annotations(genes_df = new_net1.nodes, tissue = 'colorectal cancer')\n", + "print(results_df)" + ] + }, + { + "cell_type": "markdown", + "id": "6a05e120-424b-405f-be04-f8c3725f950b", + "metadata": {}, + "source": [ + "### 3. Color nodes based on their presence/absence in the tissue of interest" + ] + }, + { + "cell_type": "code", + "execution_count": 12, + "id": "fbd98405-045a-4316-8174-e96e9a71d9ee", + "metadata": {}, + "outputs": [ + { + "data": { + "image/svg+xml": [ + "\n", + "\n", + "\n", + "\n", + "\n", + "\n", + "%3\n", + "\n", + "\n", + "\n", + "SRC\n", + "\n", + "SRC\n", + "\n", + "\n", + "\n", + "PTK2\n", + "\n", + "PTK2\n", + "\n", + "\n", + "\n", + "SRC->PTK2\n", + "\n", + "\n", + "\n", + "\n", + "\n", + "CDH2\n", + "\n", + "CDH2\n", + "\n", + "\n", + "\n", + "SRC->CDH2\n", + "\n", + "\n", + "\n", + "\n", + "\n", + "\n", + "PTK2B\n", + "\n", + "PTK2B\n", + "\n", + "\n", + "\n", + "SRC->PTK2B\n", + "\n", + "\n", + "\n", + "\n", + "\n", + "CTNNB1\n", + "\n", + "CTNNB1\n", + "\n", + "\n", + "\n", + "SRC->CTNNB1\n", + "\n", + "\n", + "\n", + "\n", + "\n", + "DAB1\n", + "\n", + "DAB1\n", + "\n", + "\n", + "\n", + "SRC->DAB1\n", + "\n", + "\n", + "\n", + "\n", + "\n", + "MET\n", + "\n", + "MET\n", + 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"\n", + "\n", + "\n", + "YAP1->CTNNB1\n", + "\n", + "\n", + "\n", + "\n", + "\n", + "YAP1->RUNX2\n", + "\n", + "\n", + "\n", + "\n", + "\n", + "\n", + "RUNX2->NOTCH1\n", + "\n", + "\n", + "\n", + "\n", + "\n", + "\n", + "EGFR->PTK2\n", + "\n", + "\n", + "\n", + "\n", + "\n", + "EGFR->CTNNB1\n", + "\n", + "\n", + "\n", + "\n", + "\n", + "EGFR->CTNND1\n", + "\n", + "\n", + "\n", + "\n", + "\n", + "\n", + "EGFR->BCAR1\n", + "\n", + "\n", + "\n", + "\n", + "\n", + "\n" + ], + "text/plain": [ + "" + ] + }, + "metadata": {}, + "output_type": "display_data" + } + ], + "source": [ + "network_visualizer = NetworkVisualizer(new_net1)\n", + "network_visualizer.tissue_mapping(results_df)\n", + "network_visualizer.render()" + ] + }, + { + "cell_type": "code", + "execution_count": 7, + "id": "db39112a", + "metadata": {}, + "outputs": [ + { + "data": { + "image/svg+xml": [ + "\n", + "\n", + "\n", + "\n", + "\n", + "\n", + "%3\n", + "\n", + "\n", + "\n", + "SRC\n", + "\n", + "SRC\n", + "\n", + "\n", + "\n", + "PTK2\n", + "\n", + "PTK2\n", + "\n", + "\n", + "\n", + "SRC->PTK2\n", + "\n", + "\n", + "\n", + "\n", + "\n", + "CDH2\n", + "\n", + "CDH2\n", + "\n", + "\n", + "\n", + "SRC->CDH2\n", + "\n", + "\n", + "\n", + "\n", + "\n", + "\n", + "PTK2B\n", + "\n", + "PTK2B\n", + "\n", + "\n", + "\n", + "SRC->PTK2B\n", + "\n", + "\n", + "\n", + "\n", + "\n", + "PTK2B->PTK2\n", + "\n", + "\n", + "\n", + "\n", + "\n", + "NOTCH1\n", + "\n", + "NOTCH1\n", + "\n", + "\n", + "\n", + "CDH1\n", + "\n", + "CDH1\n", + "\n", + "\n", + "\n", + "VIM\n", + "\n", + "VIM\n", + "\n", + "\n", + "\n", + "MAP4K4\n", + "\n", + "MAP4K4\n", + "\n", + "\n", + "\n", + "LATS1\n", + "\n", + "LATS1\n", + "\n", + "\n", + "\n", + "LATS2\n", + "\n", + "LATS2\n", + "\n", + "\n", + "\n" + ], + "text/plain": [ + "" + ] + }, + "metadata": {}, + "output_type": "display_data" + } + ], + "source": [ + "visualizer = NetworkVisualizer(new_net1, color_by='effect')\n", + "visualizer.render(output_file=\"new_network\")" + ] + } + ], + "metadata": { + "kernelspec": { + "display_name": "Python 3 (ipykernel)", + "language": "python", + "name": "python3" + }, + "language_info": { + "codemirror_mode": { + "name": "ipython", + "version": 3 + }, + "file_extension": ".py", + "mimetype": "text/x-python", + "name": "python", + "nbconvert_exporter": "python", + "pygments_lexer": "ipython3", + "version": "3.10.13" + } + }, + "nbformat": 4, + "nbformat_minor": 5 +} From 98e9ef5fe2310adbf87e60acfcf8ea490078d6ee Mon Sep 17 00:00:00 2001 From: Eirinits Date: Thu, 4 Apr 2024 11:52:27 +0200 Subject: [PATCH 09/10] Tutorial: Add ontology module --- notebooks/ontology.ipynb | 2349 ++++++++++++++++++++++++++++++++++++++ 1 file changed, 2349 insertions(+) create mode 100644 notebooks/ontology.ipynb diff --git a/notebooks/ontology.ipynb b/notebooks/ontology.ipynb new file mode 100644 index 0000000..3727cdc --- /dev/null +++ b/notebooks/ontology.ipynb @@ -0,0 +1,2349 @@ +{ + "cells": [ + { + "cell_type": "markdown", + "id": "55b5595c-fec9-41c3-b756-b95cd0c52048", + "metadata": {}, + "source": [ + "## Connect to Gene Ontology terms.\n", + "\n", + "This notebook showcases the functionality of Omniflow that connects the existing nodes of a network to a phenotype of interest. " + ] + }, + { + "cell_type": "code", + "execution_count": 1, + "id": "3c317de8", + "metadata": {}, + "outputs": [ + { + "name": "stderr", + "output_type": "stream", + "text": [ + "/home/eirini/anaconda3/envs/omniflow_env/lib/python3.10/site-packages/tqdm/auto.py:21: TqdmWarning: IProgress not found. Please update jupyter and ipywidgets. See https://ipywidgets.readthedocs.io/en/stable/user_install.html\n", + " from .autonotebook import tqdm as notebook_tqdm\n" + ] + }, + { + "name": "stdout", + "output_type": "stream", + "text": [ + "CPU times: user 1.55 s, sys: 335 ms, total: 1.88 s\n", + "Wall time: 2.07 s\n" + ] + } + ], + "source": [ + "%%time\n", + "from omniflow_project.core.network import Network\n", + "from omniflow_project._visual.visualize_network import NetworkVisualizer\n", + "from omniflow_project._inputs.resources import Resources\n", + "from omniflow_project._annotations.gene_ontology import Ontology\n", + "import omnipath as op" + ] + }, + { + "cell_type": "markdown", + "id": "2910c871-fdfc-4d20-b76f-af213f06a3f0", + "metadata": {}, + "source": [ + "### 1. Build network\n", + "\n", + "For the explanation of the individual steps, please consult the \"XX\" notebook." + ] + }, + { + "cell_type": "code", + "execution_count": 2, + "id": "79c09e13", + "metadata": {}, + "outputs": [], + "source": [ + "genes = [\"SRC\", \"NOTCH1\", \"FAK\", \"CDH1\", \"CDH2\", \"VIM\", \"MAP4K4\", \"LATS1\", \"LATS2\", \"PTK2B\"]" + ] + }, + { + "cell_type": "code", + "execution_count": 3, + "id": "fcf68a99-8454-41e3-8816-c3f976d04c0b", + "metadata": {}, + "outputs": [ + { + "name": "stdout", + "output_type": "stream", + "text": [ + "Loading deafault omnipath all interactions\n" + ] + } + ], + "source": [ + "new_net1 = Network(genes)" + ] + }, + { + "cell_type": "code", + "execution_count": 4, + "id": "370180cc", + "metadata": { + "scrolled": true + }, + "outputs": [ + { + "name": "stdout", + "output_type": "stream", + "text": [ + "P12931 Q05397\n", + "P12931 P19022\n", + "P12931 Q14289\n", + "Q14289 Q05397\n", + "CPU times: user 906 ms, sys: 11.5 ms, total: 918 ms\n", + "Wall time: 916 ms\n" + ] + } + ], + "source": [ + "%%time\n", + "new_net1.connect_nodes(only_signed=True, consensus_only=True)" + ] + }, + { + "cell_type": "code", + "execution_count": 5, + "id": "9a07d77b", + "metadata": {}, + "outputs": [ + { + "name": "stdout", + "output_type": "stream", + "text": [ + "looking for paths in the network with length: 0 for node SRC and NOTCH1\n", + "looking for paths in the network with length: 1 for node SRC and NOTCH1\n", + "looking for paths in the network with length: 2 for node SRC and NOTCH1\n", + "looking for paths in the network with length: 3 for node SRC and NOTCH1\n", + "looking for paths in the network with length: 4 for node SRC and NOTCH1\n", + "looking for paths in the network with length: 5 for node SRC and NOTCH1\n", + "looking for paths in the network with length: 6 for node SRC and NOTCH1\n", + "i_search = 3\n", + "Looking for paths with length: 0 for node SRC and NOTCH1\n", + "i_search = 3\n", + "Looking for paths with length: 1 for node SRC and NOTCH1\n", + "i_search = 3\n", + "Looking for paths with length: 2 for node SRC and NOTCH1\n", + "[['SRC', 'DAB1', 'NOTCH1'], ['SRC', 'CTNNB1', 'NOTCH1']]\n", + "P12931 O75553\n", + "O75553 P46531\n", + "P12931 P35222\n", + "P35222 P46531\n", + "P12931 Q05397\n", + "P12931 P19022\n", + "P12931 Q14289\n", + "P12931 O75553\n", + "P12931 P35222\n", + "O75553 P46531\n", + "P35222 P46531\n", + "Q14289 Q05397\n", + "P12830 P35222\n", + "P19022 P35222\n", + "looking for paths in the network with length: 0 for node SRC and PTK2\n", + "looking for paths in the network with length: 1 for node SRC and PTK2\n", + "Found a path!\n", + "[['SRC', 'PTK2']]\n", + "looking for paths in the network with length: 0 for node SRC and CDH1\n", + "looking for paths in the network with length: 1 for node SRC and CDH1\n", + "looking for paths in the network with length: 2 for node SRC and CDH1\n", + "looking for paths in the network with length: 3 for node SRC and CDH1\n", + "looking for paths in the network with length: 4 for node SRC and CDH1\n", + "looking for paths in the network with length: 5 for node SRC and CDH1\n", + "looking for paths in the network with length: 6 for node SRC and CDH1\n", + "i_search = 3\n", + "Looking for paths with length: 0 for node SRC and CDH1\n", + "i_search = 3\n", + "Looking for paths with length: 1 for node SRC and CDH1\n", + "i_search = 3\n", + "Looking for paths with length: 2 for node SRC and CDH1\n", + "[['SRC', 'CTNND1', 'CDH1'], ['SRC', 'PRKD1', 'CDH1'], ['SRC', 'MET', 'CDH1']]\n", + "P12931 O60716\n", + "O60716 P12830\n", + "P12931 Q15139\n", + "Q15139 P12830\n", + "P12931 P08581\n", + "P08581 P12830\n", + "P12931 Q05397\n", + "P12931 P19022\n", + "P12931 Q14289\n", + "P12931 O75553\n", + "P12931 P35222\n", + "P12931 O60716\n", + "P12931 Q15139\n", + "P12931 P08581\n", + "O75553 P46531\n", + "P35222 P46531\n", + "Q14289 Q05397\n", + "P08581 Q05397\n", + "P12830 P35222\n", + "O60716 P12830\n", + "Q15139 P12830\n", + "P08581 P12830\n", + "P19022 P35222\n", + "O60716 P19022\n", + "Q15139 P35222\n", + "looking for paths in the network with length: 0 for node SRC and CDH2\n", + "looking for paths in the network with length: 1 for node SRC and CDH2\n", + "Found a path!\n", + "[['SRC', 'CDH2']]\n", + "looking for paths in the network with length: 0 for node SRC and VIM\n", + "looking for paths in the network with length: 1 for node SRC and VIM\n", + "looking for paths in the network with length: 2 for node SRC and VIM\n", + "looking for paths in the network with length: 3 for node SRC and VIM\n", + "looking for paths in the network with length: 4 for node SRC and VIM\n", + "looking for paths in the network with length: 5 for node SRC and VIM\n", + "looking for paths in the network with length: 6 for node SRC and VIM\n", + "i_search = 3\n", + "Looking for paths with length: 0 for node SRC and VIM\n", + "i_search = 3\n", + "Looking for paths with length: 1 for node SRC and VIM\n", + "i_search = 3\n", + "Looking for paths with length: 2 for node SRC and VIM\n", + "[['SRC', 'PAK2', 'VIM']]\n", + "P12931 Q13177\n", + "Q13177 P08670\n", + "P12931 Q05397\n", + "P12931 P19022\n", + "P12931 Q14289\n", + "P12931 O75553\n", + "P12931 P35222\n", + "P12931 O60716\n", + "P12931 Q15139\n", + "P12931 P08581\n", + "P12931 Q13177\n", + "O75553 P46531\n", + "P35222 P46531\n", + "Q14289 Q05397\n", + "P08581 Q05397\n", + "P12830 P35222\n", + "O60716 P12830\n", + "Q15139 P12830\n", + "P08581 P12830\n", + "P19022 P35222\n", + "O60716 P19022\n", + "Q13177 P08670\n", + "Q15139 P35222\n", + "looking for paths in the network with length: 0 for node SRC and MAP4K4\n", + "looking for paths in the network with length: 1 for node SRC and MAP4K4\n", + "looking for paths in the network with length: 2 for node SRC and MAP4K4\n", + "looking for paths in the network with length: 3 for node SRC and MAP4K4\n", + "looking for paths in the network with length: 4 for node SRC and MAP4K4\n", + "looking for paths in the network with length: 5 for node SRC and MAP4K4\n", + "looking for paths in the network with length: 6 for node SRC and MAP4K4\n", + "i_search = 3\n", + "Looking for paths with length: 0 for node SRC and MAP4K4\n", + "i_search = 3\n", + "Looking for paths with length: 1 for node SRC and MAP4K4\n", + "i_search = 3\n", + "Looking for paths with length: 2 for node SRC and MAP4K4\n", + "i_search = 3\n", + "Looking for paths with length: 3 for node SRC and MAP4K4\n", + "[['SRC', 'MAPK8', 'MAP3K1', 'MAP4K4'], ['SRC', 'MAPK8', 'MAP3K7', 'MAP4K4']]\n", + "P45983 P12931\n", + "Q13233 P45983\n", + "O95819 Q13233\n", + "P45983 P12931\n", + "O43318 P45983\n", + "O95819 O43318\n", + "P12931 Q05397\n", + "P12931 P19022\n", + "P12931 Q14289\n", + "P12931 O75553\n", + "P12931 P35222\n", + "P12931 O60716\n", + "P12931 Q15139\n", + "P12931 P08581\n", + "P12931 Q13177\n", + "P45983 P12931\n", + "O75553 P46531\n", + "P35222 P46531\n", + "Q14289 Q05397\n", + "P08581 Q05397\n", + "P12830 P35222\n", + "O60716 P12830\n", + "Q15139 P12830\n", + "P08581 P12830\n", + "P19022 P35222\n", + "O60716 P19022\n", + "Q13177 P08670\n", + "O95819 Q13233\n", + "O95819 O43318\n", + "Q15139 P35222\n", + "Q13233 P45983\n", + "O43318 P45983\n", + "looking for paths in the network with length: 0 for node SRC and LATS1\n", + "looking for paths in the network with length: 1 for node SRC and LATS1\n", + "looking for paths in the network with length: 2 for node SRC and LATS1\n", + "looking for paths in the network with length: 3 for node SRC and LATS1\n", + "looking for paths in the network with length: 4 for node SRC and LATS1\n", + "looking for paths in the network with length: 5 for node SRC and LATS1\n", + "looking for paths in the network with length: 6 for node SRC and LATS1\n", + "i_search = 3\n", + "Looking for paths with length: 0 for node SRC and LATS1\n", + "i_search = 3\n", + "Looking for paths with length: 1 for node SRC and LATS1\n", + "i_search = 3\n", + "Looking for paths with length: 2 for node SRC and LATS1\n", + "i_search = 3\n", + "Looking for paths with length: 3 for node SRC and LATS1\n", + "[['SRC', 'RAF1', 'STK3', 'LATS1'], ['SRC', 'RAF1', 'STK4', 'LATS1'], ['SRC', 'PAK2', 'NF2', 'LATS1']]\n", + "P12931 P04049\n", + "P04049 Q13188\n", + "Q13188 O95835\n", + "P12931 P04049\n", + "P04049 Q13043\n", + "Q13043 O95835\n", + "P12931 Q13177\n", + "Q13177 P35240\n", + "P35240 O95835\n", + "P12931 Q05397\n", + "P12931 P19022\n", + "P12931 Q14289\n", + "P12931 O75553\n", + "P12931 P35222\n", + "P12931 O60716\n", + "P12931 Q15139\n", + "P12931 P08581\n", + "P12931 Q13177\n", + "P45983 P12931\n", + "P12931 P04049\n", + "O75553 P46531\n", + "P35222 P46531\n", + "Q14289 Q05397\n", + "P08581 Q05397\n", + "P12830 P35222\n", + "O60716 P12830\n", + "Q15139 P12830\n", + "P08581 P12830\n", + "P19022 P35222\n", + "O60716 P19022\n", + "Q13177 P08670\n", + "O95819 Q13233\n", + "O95819 O43318\n", + "Q13188 O95835\n", + "Q13043 O95835\n", + "P35240 O95835\n", + "Q13188 Q9NRM7\n", + "Q13043 Q9NRM7\n", + "P35240 Q9NRM7\n", + "Q15139 P35222\n", + "Q13177 P04049\n", + "Q13177 P35240\n", + "Q13233 P45983\n", + "O43318 P45983\n", + "P45983 Q13043\n", + "P04049 Q13188\n", + "P04049 Q13043\n", + "P35240 Q13188\n", + "P35240 Q13043\n", + "looking for paths in the network with length: 0 for node SRC and LATS2\n", + "looking for paths in the network with length: 1 for node SRC and LATS2\n", + "looking for paths in the network with length: 2 for node SRC and LATS2\n", + "looking for paths in the network with length: 3 for node SRC and LATS2\n", + "Found a path!\n", + "[['SRC', 'RAF1', 'STK3', 'LATS2'], ['SRC', 'RAF1', 'STK4', 'LATS2'], ['SRC', 'PAK2', 'NF2', 'LATS2']]\n", + "looking for paths in the network with length: 0 for node SRC and PTK2B\n", + "looking for paths in the network with length: 1 for node SRC and PTK2B\n", + "Found a path!\n", + "[['SRC', 'PTK2B']]\n", + "looking for paths in the network with length: 0 for node NOTCH1 and PTK2\n", + "looking for paths in the network with length: 1 for node NOTCH1 and PTK2\n", + "looking for paths in the network with length: 2 for node NOTCH1 and PTK2\n", + "looking for paths in the network with length: 3 for node NOTCH1 and PTK2\n", + "looking for paths in the network with length: 4 for node NOTCH1 and PTK2\n", + "looking for paths in the network with length: 5 for node NOTCH1 and PTK2\n", + "looking for paths in the network with length: 6 for node NOTCH1 and PTK2\n", + "i_search = 3\n", + "Looking for paths with length: 0 for node NOTCH1 and PTK2\n", + "i_search = 3\n", + "Looking for paths with length: 1 for node NOTCH1 and PTK2\n", + "i_search = 3\n", + "Looking for paths with length: 2 for node NOTCH1 and PTK2\n", + "i_search = 3\n", + "Looking for paths with length: 3 for node NOTCH1 and PTK2\n", + "[['NOTCH1', 'SMAD3', 'BCAR1', 'PTK2'], ['NOTCH1', 'LCK', 'PTPRH', 'PTK2']]\n", + "P84022 P46531\n", + "P56945 P84022\n", + "Q05397 P56945\n", + "P06239 P46531\n", + "Q9HD43 P06239\n", + "Q9HD43 Q05397\n", + "P12931 Q05397\n", + "P12931 P19022\n", + "P12931 Q14289\n", + "P12931 O75553\n", + "P12931 P35222\n", + "P12931 O60716\n", + "P12931 Q15139\n", + "P12931 P08581\n", + "P12931 Q13177\n", + "P45983 P12931\n", + "P12931 P04049\n", + "P12931 P56945\n", + "Q9HD43 P12931\n", + "O75553 P46531\n", + "P35222 P46531\n", + "P84022 P46531\n", + "P06239 P46531\n", + "Q14289 Q05397\n", + "P08581 Q05397\n", + "Q05397 P56945\n", + "Q05397 Q9HD43\n", + "Q9HD43 Q05397\n", + "P12830 P35222\n", + "O60716 P12830\n", + "Q15139 P12830\n", + "P08581 P12830\n", + "P19022 P35222\n", + "O60716 P19022\n", + "Q13177 P08670\n", + "O95819 Q13233\n", + "O95819 O43318\n", + "Q13188 O95835\n", + "Q13043 O95835\n", + "P35240 O95835\n", + "Q13188 Q9NRM7\n", + "Q13043 Q9NRM7\n", + "P35240 Q9NRM7\n", + "Q15139 P35222\n", + "Q13177 P04049\n", + "Q13177 P35240\n", + "Q13233 P45983\n", + "O43318 P45983\n", + "P45983 Q13043\n", + "P45983 P84022\n", + "O43318 P84022\n", + "P04049 Q13188\n", + "P04049 Q13043\n", + "P06239 P04049\n", + "P35240 Q13188\n", + "P35240 Q13043\n", + "P56945 P84022\n", + "Q9HD43 P56945\n", + "Q9HD43 P06239\n", + "looking for paths in the network with length: 0 for node NOTCH1 and CDH1\n", + "looking for paths in the network with length: 1 for node NOTCH1 and CDH1\n", + "looking for paths in the network with length: 2 for node NOTCH1 and CDH1\n", + "Found a path!\n", + "[['NOTCH1', 'CTNNB1', 'CDH1']]\n", + "looking for paths in the network with length: 0 for node NOTCH1 and CDH2\n", + "looking for paths in the network with length: 1 for node NOTCH1 and CDH2\n", + "looking for paths in the network with length: 2 for node NOTCH1 and CDH2\n", + "Found a path!\n", + "[['NOTCH1', 'CTNNB1', 'CDH2']]\n", + "looking for paths in the network with length: 0 for node NOTCH1 and VIM\n", + "looking for paths in the network with length: 1 for node NOTCH1 and VIM\n", + "looking for paths in the network with length: 2 for node NOTCH1 and VIM\n", + "looking for paths in the network with length: 3 for node NOTCH1 and VIM\n", + "looking for paths in the network with length: 4 for node NOTCH1 and VIM\n", + "looking for paths in the network with length: 5 for node NOTCH1 and VIM\n", + "looking for paths in the network with length: 6 for node NOTCH1 and VIM\n", + "i_search = 3\n", + "Looking for paths with length: 0 for node NOTCH1 and VIM\n", + "i_search = 3\n", + "Looking for paths with length: 1 for node NOTCH1 and VIM\n", + "i_search = 3\n", + "Looking for paths with length: 2 for node NOTCH1 and VIM\n", + "i_search = 3\n", + "Looking for paths with length: 3 for node NOTCH1 and VIM\n", + "looking for paths in the network with length: 0 for node NOTCH1 and MAP4K4\n", + "looking for paths in the network with length: 1 for node NOTCH1 and MAP4K4\n", + "looking for paths in the network with length: 2 for node NOTCH1 and MAP4K4\n", + "looking for paths in the network with length: 3 for node NOTCH1 and MAP4K4\n", + "Found a path!\n", + "[['NOTCH1', 'SMAD3', 'MAP3K7', 'MAP4K4']]\n", + "looking for paths in the network with length: 0 for node NOTCH1 and LATS1\n", + "looking for paths in the network with length: 1 for node NOTCH1 and LATS1\n", + "looking for paths in the network with length: 2 for node NOTCH1 and LATS1\n", + "looking for paths in the network with length: 3 for node NOTCH1 and LATS1\n", + "looking for paths in the network with length: 4 for node NOTCH1 and LATS1\n", + "looking for paths in the network with length: 5 for node NOTCH1 and LATS1\n", + "looking for paths in the network with length: 6 for node NOTCH1 and LATS1\n", + "i_search = 3\n", + "Looking for paths with length: 0 for node NOTCH1 and LATS1\n", + "i_search = 3\n", + "Looking for paths with length: 1 for node NOTCH1 and LATS1\n", + "i_search = 3\n", + "Looking for paths with length: 2 for node NOTCH1 and LATS1\n", + "i_search = 3\n", + "Looking for paths with length: 3 for node NOTCH1 and LATS1\n", + "[['NOTCH1', 'SMAD3', 'WWTR1', 'LATS1'], ['NOTCH1', 'RUNX2', 'YAP1', 'LATS1'], ['NOTCH1', 'RUNX2', 'WWTR1', 'LATS1'], ['NOTCH1', 'CTNNB1', 'YAP1', 'LATS1']]\n", + "P84022 P46531\n", + "Q9GZV5 P84022\n", + "O95835 Q9GZV5\n", + "Q13950 P46531\n", + "P46937 Q13950\n", + "O95835 P46937\n", + "Q13950 P46531\n", + "Q9GZV5 Q13950\n", + "O95835 Q9GZV5\n", + "P35222 P46531\n", + "P46937 P35222\n", + "O95835 P46937\n", + "P12931 Q05397\n", + "P12931 P19022\n", + "P12931 Q14289\n", + "P12931 O75553\n", + "P12931 P35222\n", + "P12931 O60716\n", + "P12931 Q15139\n", + "P12931 P08581\n", + "P12931 Q13177\n", + "P45983 P12931\n", + "P12931 P04049\n", + "P12931 P56945\n", + "Q9HD43 P12931\n", + "O75553 P46531\n", + "P35222 P46531\n", + "P84022 P46531\n", + "P06239 P46531\n", + "Q13950 P46531\n", + "Q14289 Q05397\n", + "P08581 Q05397\n", + "Q05397 P56945\n", + "Q05397 Q9HD43\n", + "Q9HD43 Q05397\n", + "P12830 P35222\n", + "O60716 P12830\n", + "Q15139 P12830\n", + "P08581 P12830\n", + "P19022 P35222\n", + "O60716 P19022\n", + "Q13177 P08670\n", + "O95819 Q13233\n", + "O95819 O43318\n", + "Q13188 O95835\n", + "Q13043 O95835\n", + "P35240 O95835\n", + "O95835 Q9GZV5\n", + "O95835 P46937\n", + "Q13188 Q9NRM7\n", + "Q13043 Q9NRM7\n", + "P35240 Q9NRM7\n", + "Q9NRM7 Q9GZV5\n", + "Q9NRM7 P46937\n", + "Q15139 P35222\n", + "P46937 P35222\n", + "Q13177 P04049\n", + "Q13177 P35240\n", + "Q13233 P45983\n", + "O43318 P45983\n", + "P45983 Q13043\n", + "P45983 P84022\n", + "O43318 P84022\n", + "P04049 Q13188\n", + "P04049 Q13043\n", + "P06239 P04049\n", + "P35240 Q13188\n", + "P35240 Q13043\n", + "P56945 P84022\n", + "Q9GZV5 P84022\n", + "P84022 Q13950\n", + "Q9HD43 P56945\n", + "Q9HD43 P06239\n", + "Q9GZV5 Q13950\n", + "P46937 Q13950\n", + "looking for paths in the network with length: 0 for node NOTCH1 and LATS2\n", + "looking for paths in the network with length: 1 for node NOTCH1 and LATS2\n", + "looking for paths in the network with length: 2 for node NOTCH1 and LATS2\n", + "looking for paths in the network with length: 3 for node NOTCH1 and LATS2\n", + "Found a path!\n", + "[['NOTCH1', 'SMAD3', 'WWTR1', 'LATS2'], ['NOTCH1', 'CTNNB1', 'YAP1', 'LATS2'], ['NOTCH1', 'RUNX2', 'YAP1', 'LATS2'], ['NOTCH1', 'RUNX2', 'WWTR1', 'LATS2']]\n", + "looking for paths in the network with length: 0 for node NOTCH1 and PTK2B\n", + "looking for paths in the network with length: 1 for node NOTCH1 and PTK2B\n", + "looking for paths in the network with length: 2 for node NOTCH1 and PTK2B\n", + "looking for paths in the network with length: 3 for node NOTCH1 and PTK2B\n", + "looking for paths in the network with length: 4 for node NOTCH1 and PTK2B\n", + "Found a path!\n", + "[['NOTCH1', 'SMAD3', 'BCAR1', 'PTK2', 'PTK2B'], ['NOTCH1', 'LCK', 'PTPRH', 'PTK2', 'PTK2B']]\n", + "looking for paths in the network with length: 0 for node PTK2 and CDH1\n", + "looking for paths in the network with length: 1 for node PTK2 and CDH1\n", + "looking for paths in the network with length: 2 for node PTK2 and CDH1\n", + "looking for paths in the network with length: 3 for node PTK2 and CDH1\n", + "looking for paths in the network with length: 4 for node PTK2 and CDH1\n", + "Found a path!\n", + "[['PTK2', 'PTPRH', 'SRC', 'CTNND1', 'CDH1'], ['PTK2', 'PTPRH', 'SRC', 'MET', 'CDH1'], ['PTK2', 'PTPRH', 'SRC', 'PRKD1', 'CDH1']]\n", + "looking for paths in the network with length: 0 for node PTK2 and CDH2\n", + "looking for paths in the network with length: 1 for node PTK2 and CDH2\n", + "looking for paths in the network with length: 2 for node PTK2 and CDH2\n", + "looking for paths in the network with length: 3 for node PTK2 and CDH2\n", + "Found a path!\n", + "[['PTK2', 'PTPRH', 'SRC', 'CDH2']]\n", + "looking for paths in the network with length: 0 for node PTK2 and VIM\n", + "looking for paths in the network with length: 1 for node PTK2 and VIM\n", + "looking for paths in the network with length: 2 for node PTK2 and VIM\n", + "looking for paths in the network with length: 3 for node PTK2 and VIM\n", + "looking for paths in the network with length: 4 for node PTK2 and VIM\n", + "Found a path!\n", + "[['PTK2', 'PTPRH', 'SRC', 'PAK2', 'VIM']]\n", + "looking for paths in the network with length: 0 for node PTK2 and MAP4K4\n", + "looking for paths in the network with length: 1 for node PTK2 and MAP4K4\n", + "looking for paths in the network with length: 2 for node PTK2 and MAP4K4\n", + "looking for paths in the network with length: 3 for node PTK2 and MAP4K4\n", + "looking for paths in the network with length: 4 for node PTK2 and MAP4K4\n", + "Found a path!\n", + "[['PTK2', 'SRC', 'MAPK8', 'MAP3K7', 'MAP4K4'], ['PTK2', 'SRC', 'MAPK8', 'MAP3K1', 'MAP4K4']]\n", + "looking for paths in the network with length: 0 for node PTK2 and LATS1\n", + "looking for paths in the network with length: 1 for node PTK2 and LATS1\n", + "looking for paths in the network with length: 2 for node PTK2 and LATS1\n", + "looking for paths in the network with length: 3 for node PTK2 and LATS1\n", + "looking for paths in the network with length: 4 for node PTK2 and LATS1\n", + "looking for paths in the network with length: 5 for node PTK2 and LATS1\n", + "Found a path!\n", + "[['PTK2', 'PTPRH', 'SRC', 'RAF1', 'STK3', 'LATS1'], ['PTK2', 'PTPRH', 'SRC', 'RAF1', 'STK4', 'LATS1'], ['PTK2', 'PTPRH', 'SRC', 'PAK2', 'NF2', 'LATS1'], ['PTK2', 'PTPRH', 'LCK', 'RAF1', 'STK3', 'LATS1'], ['PTK2', 'PTPRH', 'LCK', 'RAF1', 'STK4', 'LATS1']]\n", + "looking for paths in the network with length: 0 for node PTK2 and LATS2\n", + "looking for paths in the network with length: 1 for node PTK2 and LATS2\n", + "looking for paths in the network with length: 2 for node PTK2 and LATS2\n", + "looking for paths in the network with length: 3 for node PTK2 and LATS2\n", + "looking for paths in the network with length: 4 for node PTK2 and LATS2\n", + "looking for paths in the network with length: 5 for node PTK2 and LATS2\n", + "Found a path!\n", + "[['PTK2', 'PTPRH', 'SRC', 'RAF1', 'STK3', 'LATS2'], ['PTK2', 'PTPRH', 'SRC', 'RAF1', 'STK4', 'LATS2'], ['PTK2', 'PTPRH', 'SRC', 'PAK2', 'NF2', 'LATS2'], ['PTK2', 'PTPRH', 'LCK', 'RAF1', 'STK3', 'LATS2'], ['PTK2', 'PTPRH', 'LCK', 'RAF1', 'STK4', 'LATS2']]\n", + "looking for paths in the network with length: 0 for node PTK2 and PTK2B\n", + "looking for paths in the network with length: 1 for node PTK2 and PTK2B\n", + "Found a path!\n", + "[['PTK2', 'PTK2B']]\n", + "looking for paths in the network with length: 0 for node CDH1 and CDH2\n", + "looking for paths in the network with length: 1 for node CDH1 and CDH2\n", + "looking for paths in the network with length: 2 for node CDH1 and CDH2\n", + "looking for paths in the network with length: 3 for node CDH1 and CDH2\n", + "looking for paths in the network with length: 4 for node CDH1 and CDH2\n", + "looking for paths in the network with length: 5 for node CDH1 and CDH2\n", + "looking for paths in the network with length: 6 for node CDH1 and CDH2\n", + "i_search = 3\n", + "Looking for paths with length: 0 for node CDH1 and CDH2\n", + "i_search = 3\n", + "Looking for paths with length: 1 for node CDH1 and CDH2\n", + "i_search = 3\n", + "Looking for paths with length: 2 for node CDH1 and CDH2\n", + "i_search = 3\n", + "Looking for paths with length: 3 for node CDH1 and CDH2\n", + "[['CDH1', 'EGFR', 'CTNND1', 'CDH2']]\n", + "P12830 P00533\n", + "P00533 O60716\n", + "O60716 P19022\n", + "P12931 Q05397\n", + "P12931 P19022\n", + "P12931 Q14289\n", + "P12931 O75553\n", + "P12931 P35222\n", + "P12931 O60716\n", + "P12931 Q15139\n", + "P12931 P08581\n", + "P12931 Q13177\n", + "P45983 P12931\n", + "P12931 P04049\n", + "P12931 P56945\n", + "Q9HD43 P12931\n", + "P12931 P00533\n", + "O75553 P46531\n", + "P35222 P46531\n", + "P84022 P46531\n", + "P06239 P46531\n", + "Q13950 P46531\n", + "Q14289 Q05397\n", + "P08581 Q05397\n", + "Q05397 P56945\n", + "Q05397 Q9HD43\n", + "Q9HD43 Q05397\n", + "P00533 Q05397\n", + "P12830 P35222\n", + "O60716 P12830\n", + "Q15139 P12830\n", + "P08581 P12830\n", + "P12830 P00533\n", + "P19022 P35222\n", + "O60716 P19022\n", + "Q13177 P08670\n", + "O95819 Q13233\n", + "O95819 O43318\n", + "Q13188 O95835\n", + "Q13043 O95835\n", + "P35240 O95835\n", + "O95835 Q9GZV5\n", + "O95835 P46937\n", + "Q13188 Q9NRM7\n", + "Q13043 Q9NRM7\n", + "P35240 Q9NRM7\n", + "Q9NRM7 Q9GZV5\n", + "Q9NRM7 P46937\n", + "Q14289 P00533\n", + "Q15139 P35222\n", + "P46937 P35222\n", + "P00533 P35222\n", + "P00533 O60716\n", + "Q15139 P00533\n", + "Q13177 P04049\n", + "Q13177 P35240\n", + "Q13233 P45983\n", + "O43318 P45983\n", + "P45983 Q13043\n", + "P45983 P84022\n", + "O43318 P84022\n", + "P04049 Q13188\n", + "P04049 Q13043\n", + "P06239 P04049\n", + "P35240 Q13188\n", + "P35240 Q13043\n", + "P56945 P84022\n", + "Q9GZV5 P84022\n", + "P84022 Q13950\n", + "Q9HD43 P56945\n", + "P00533 P56945\n", + "Q9HD43 P06239\n", + "Q9GZV5 Q13950\n", + "P46937 Q13950\n", + "looking for paths in the network with length: 0 for node CDH1 and VIM\n", + "looking for paths in the network with length: 1 for node CDH1 and VIM\n", + "looking for paths in the network with length: 2 for node CDH1 and VIM\n", + "looking for paths in the network with length: 3 for node CDH1 and VIM\n", + "looking for paths in the network with length: 4 for node CDH1 and VIM\n", + "looking for paths in the network with length: 5 for node CDH1 and VIM\n", + "looking for paths in the network with length: 6 for node CDH1 and VIM\n", + "Found a path!\n", + "[['CDH1', 'EGFR', 'PTK2', 'PTPRH', 'SRC', 'PAK2', 'VIM']]\n", + "looking for paths in the network with length: 0 for node CDH1 and MAP4K4\n", + "looking for paths in the network with length: 1 for node CDH1 and MAP4K4\n", + "looking for paths in the network with length: 2 for node CDH1 and MAP4K4\n", + "looking for paths in the network with length: 3 for node CDH1 and MAP4K4\n", + "looking for paths in the network with length: 4 for node CDH1 and MAP4K4\n", + "looking for paths in the network with length: 5 for node CDH1 and MAP4K4\n", + "Found a path!\n", + "[['CDH1', 'CTNND1', 'SRC', 'MAPK8', 'MAP3K7', 'MAP4K4'], ['CDH1', 'CTNND1', 'SRC', 'MAPK8', 'MAP3K1', 'MAP4K4'], ['CDH1', 'PRKD1', 'SRC', 'MAPK8', 'MAP3K7', 'MAP4K4'], ['CDH1', 'PRKD1', 'SRC', 'MAPK8', 'MAP3K1', 'MAP4K4'], ['CDH1', 'MET', 'SRC', 'MAPK8', 'MAP3K7', 'MAP4K4'], ['CDH1', 'MET', 'SRC', 'MAPK8', 'MAP3K1', 'MAP4K4']]\n", + "looking for paths in the network with length: 0 for node CDH1 and LATS1\n", + "looking for paths in the network with length: 1 for node CDH1 and LATS1\n", + "looking for paths in the network with length: 2 for node CDH1 and LATS1\n", + "looking for paths in the network with length: 3 for node CDH1 and LATS1\n", + "looking for paths in the network with length: 4 for node CDH1 and LATS1\n", + "looking for paths in the network with length: 5 for node CDH1 and LATS1\n", + "looking for paths in the network with length: 6 for node CDH1 and LATS1\n", + "i_search = 3\n", + "Looking for paths with length: 0 for node CDH1 and LATS1\n", + "i_search = 3\n", + "Looking for paths with length: 1 for node CDH1 and LATS1\n", + "i_search = 3\n", + "Looking for paths with length: 2 for node CDH1 and LATS1\n", + "i_search = 3\n", + "Looking for paths with length: 3 for node CDH1 and LATS1\n", + "looking for paths in the network with length: 0 for node CDH1 and LATS2\n", + "looking for paths in the network with length: 1 for node CDH1 and LATS2\n", + "looking for paths in the network with length: 2 for node CDH1 and LATS2\n", + "looking for paths in the network with length: 3 for node CDH1 and LATS2\n", + "looking for paths in the network with length: 4 for node CDH1 and LATS2\n", + "looking for paths in the network with length: 5 for node CDH1 and LATS2\n", + "looking for paths in the network with length: 6 for node CDH1 and LATS2\n", + "i_search = 3\n", + "Looking for paths with length: 0 for node CDH1 and LATS2\n", + "i_search = 3\n", + "Looking for paths with length: 1 for node CDH1 and LATS2\n", + "i_search = 3\n", + "Looking for paths with length: 2 for node CDH1 and LATS2\n", + "i_search = 3\n", + "Looking for paths with length: 3 for node CDH1 and LATS2\n", + "looking for paths in the network with length: 0 for node CDH1 and PTK2B\n", + "looking for paths in the network with length: 1 for node CDH1 and PTK2B\n", + "looking for paths in the network with length: 2 for node CDH1 and PTK2B\n", + "looking for paths in the network with length: 3 for node CDH1 and PTK2B\n", + "Found a path!\n", + "[['CDH1', 'CTNND1', 'EGFR', 'PTK2B']]\n", + "looking for paths in the network with length: 0 for node CDH2 and VIM\n", + "looking for paths in the network with length: 1 for node CDH2 and VIM\n", + "looking for paths in the network with length: 2 for node CDH2 and VIM\n", + "looking for paths in the network with length: 3 for node CDH2 and VIM\n", + "looking for paths in the network with length: 4 for node CDH2 and VIM\n", + "looking for paths in the network with length: 5 for node CDH2 and VIM\n", + "looking for paths in the network with length: 6 for node CDH2 and VIM\n", + "i_search = 3\n", + "Looking for paths with length: 0 for node CDH2 and VIM\n", + "i_search = 3\n", + "Looking for paths with length: 1 for node CDH2 and VIM\n", + "i_search = 3\n", + "Looking for paths with length: 2 for node CDH2 and VIM\n", + "i_search = 3\n", + "Looking for paths with length: 3 for node CDH2 and VIM\n", + "looking for paths in the network with length: 0 for node CDH2 and MAP4K4\n", + "looking for paths in the network with length: 1 for node CDH2 and MAP4K4\n", + "looking for paths in the network with length: 2 for node CDH2 and MAP4K4\n", + "looking for paths in the network with length: 3 for node CDH2 and MAP4K4\n", + "looking for paths in the network with length: 4 for node CDH2 and MAP4K4\n", + "Found a path!\n", + "[['CDH2', 'SRC', 'MAPK8', 'MAP3K7', 'MAP4K4'], ['CDH2', 'SRC', 'MAPK8', 'MAP3K1', 'MAP4K4']]\n", + "looking for paths in the network with length: 0 for node CDH2 and LATS1\n", + "looking for paths in the network with length: 1 for node CDH2 and LATS1\n", + "looking for paths in the network with length: 2 for node CDH2 and LATS1\n", + "looking for paths in the network with length: 3 for node CDH2 and LATS1\n", + "looking for paths in the network with length: 4 for node CDH2 and LATS1\n", + "looking for paths in the network with length: 5 for node CDH2 and LATS1\n", + "looking for paths in the network with length: 6 for node CDH2 and LATS1\n", + "i_search = 3\n", + "Looking for paths with length: 0 for node CDH2 and LATS1\n", + "i_search = 3\n", + "Looking for paths with length: 1 for node CDH2 and LATS1\n", + "i_search = 3\n", + "Looking for paths with length: 2 for node CDH2 and LATS1\n", + "i_search = 3\n", + "Looking for paths with length: 3 for node CDH2 and LATS1\n", + "looking for paths in the network with length: 0 for node CDH2 and LATS2\n", + "looking for paths in the network with length: 1 for node CDH2 and LATS2\n", + "looking for paths in the network with length: 2 for node CDH2 and LATS2\n", + "looking for paths in the network with length: 3 for node CDH2 and LATS2\n", + "looking for paths in the network with length: 4 for node CDH2 and LATS2\n", + "looking for paths in the network with length: 5 for node CDH2 and LATS2\n", + "looking for paths in the network with length: 6 for node CDH2 and LATS2\n", + "i_search = 3\n", + "Looking for paths with length: 0 for node CDH2 and LATS2\n", + "i_search = 3\n", + "Looking for paths with length: 1 for node CDH2 and LATS2\n", + "i_search = 3\n", + "Looking for paths with length: 2 for node CDH2 and LATS2\n", + "i_search = 3\n", + "Looking for paths with length: 3 for node CDH2 and LATS2\n", + "looking for paths in the network with length: 0 for node CDH2 and PTK2B\n", + "looking for paths in the network with length: 1 for node CDH2 and PTK2B\n", + "looking for paths in the network with length: 2 for node CDH2 and PTK2B\n", + "looking for paths in the network with length: 3 for node CDH2 and PTK2B\n", + "Found a path!\n", + "[['CDH2', 'CTNND1', 'EGFR', 'PTK2B']]\n", + "looking for paths in the network with length: 0 for node VIM and MAP4K4\n", + "looking for paths in the network with length: 1 for node VIM and MAP4K4\n", + "looking for paths in the network with length: 2 for node VIM and MAP4K4\n", + "looking for paths in the network with length: 3 for node VIM and MAP4K4\n", + "looking for paths in the network with length: 4 for node VIM and MAP4K4\n", + "looking for paths in the network with length: 5 for node VIM and MAP4K4\n", + "Found a path!\n", + "[['VIM', 'PAK2', 'SRC', 'MAPK8', 'MAP3K7', 'MAP4K4'], ['VIM', 'PAK2', 'SRC', 'MAPK8', 'MAP3K1', 'MAP4K4']]\n", + "looking for paths in the network with length: 0 for node VIM and LATS1\n", + "looking for paths in the network with length: 1 for node VIM and LATS1\n", + "looking for paths in the network with length: 2 for node VIM and LATS1\n", + "looking for paths in the network with length: 3 for node VIM and LATS1\n", + "looking for paths in the network with length: 4 for node VIM and LATS1\n", + "looking for paths in the network with length: 5 for node VIM and LATS1\n", + "looking for paths in the network with length: 6 for node VIM and LATS1\n", + "i_search = 3\n", + "Looking for paths with length: 0 for node VIM and LATS1\n", + "i_search = 3\n", + "Looking for paths with length: 1 for node VIM and LATS1\n", + "i_search = 3\n", + "Looking for paths with length: 2 for node VIM and LATS1\n", + "i_search = 3\n", + "Looking for paths with length: 3 for node VIM and LATS1\n", + "looking for paths in the network with length: 0 for node VIM and LATS2\n", + "looking for paths in the network with length: 1 for node VIM and LATS2\n", + "looking for paths in the network with length: 2 for node VIM and LATS2\n", + "looking for paths in the network with length: 3 for node VIM and LATS2\n", + "looking for paths in the network with length: 4 for node VIM and LATS2\n", + "looking for paths in the network with length: 5 for node VIM and LATS2\n", + "looking for paths in the network with length: 6 for node VIM and LATS2\n", + "i_search = 3\n", + "Looking for paths with length: 0 for node VIM and LATS2\n", + "i_search = 3\n", + "Looking for paths with length: 1 for node VIM and LATS2\n", + "i_search = 3\n", + "Looking for paths with length: 2 for node VIM and LATS2\n", + "i_search = 3\n", + "Looking for paths with length: 3 for node VIM and LATS2\n", + "looking for paths in the network with length: 0 for node VIM and PTK2B\n", + "looking for paths in the network with length: 1 for node VIM and PTK2B\n", + "looking for paths in the network with length: 2 for node VIM and PTK2B\n", + "looking for paths in the network with length: 3 for node VIM and PTK2B\n", + "looking for paths in the network with length: 4 for node VIM and PTK2B\n", + "looking for paths in the network with length: 5 for node VIM and PTK2B\n", + "Found a path!\n", + "[['VIM', 'PAK2', 'SRC', 'PTPRH', 'PTK2', 'PTK2B']]\n", + "looking for paths in the network with length: 0 for node MAP4K4 and LATS1\n", + "looking for paths in the network with length: 1 for node MAP4K4 and LATS1\n", + "looking for paths in the network with length: 2 for node MAP4K4 and LATS1\n", + "looking for paths in the network with length: 3 for node MAP4K4 and LATS1\n", + "looking for paths in the network with length: 4 for node MAP4K4 and LATS1\n", + "Found a path!\n", + "[['MAP4K4', 'MAP3K7', 'MAPK8', 'STK4', 'LATS1'], ['MAP4K4', 'MAP3K1', 'MAPK8', 'STK4', 'LATS1']]\n", + "looking for paths in the network with length: 0 for node MAP4K4 and LATS2\n", + "looking for paths in the network with length: 1 for node MAP4K4 and LATS2\n", + "looking for paths in the network with length: 2 for node MAP4K4 and LATS2\n", + "looking for paths in the network with length: 3 for node MAP4K4 and LATS2\n", + "looking for paths in the network with length: 4 for node MAP4K4 and LATS2\n", + "Found a path!\n", + "[['MAP4K4', 'MAP3K7', 'MAPK8', 'STK4', 'LATS2'], ['MAP4K4', 'MAP3K1', 'MAPK8', 'STK4', 'LATS2']]\n", + "looking for paths in the network with length: 0 for node MAP4K4 and PTK2B\n", + "looking for paths in the network with length: 1 for node MAP4K4 and PTK2B\n", + "looking for paths in the network with length: 2 for node MAP4K4 and PTK2B\n", + "looking for paths in the network with length: 3 for node MAP4K4 and PTK2B\n", + "looking for paths in the network with length: 4 for node MAP4K4 and PTK2B\n", + "Found a path!\n", + "[['MAP4K4', 'MAP3K7', 'MAPK8', 'SRC', 'PTK2B'], ['MAP4K4', 'MAP3K1', 'MAPK8', 'SRC', 'PTK2B']]\n", + "looking for paths in the network with length: 0 for node LATS1 and LATS2\n", + "looking for paths in the network with length: 1 for node LATS1 and LATS2\n", + "looking for paths in the network with length: 2 for node LATS1 and LATS2\n", + "looking for paths in the network with length: 3 for node LATS1 and LATS2\n", + "looking for paths in the network with length: 4 for node LATS1 and LATS2\n", + "looking for paths in the network with length: 5 for node LATS1 and LATS2\n", + "looking for paths in the network with length: 6 for node LATS1 and LATS2\n", + "i_search = 3\n", + "Looking for paths with length: 0 for node LATS1 and LATS2\n", + "i_search = 3\n", + "Looking for paths with length: 1 for node LATS1 and LATS2\n", + "i_search = 3\n", + "Looking for paths with length: 2 for node LATS1 and LATS2\n", + "i_search = 3\n", + "Looking for paths with length: 3 for node LATS1 and LATS2\n", + "looking for paths in the network with length: 0 for node LATS1 and PTK2B\n", + "looking for paths in the network with length: 1 for node LATS1 and PTK2B\n", + "looking for paths in the network with length: 2 for node LATS1 and PTK2B\n", + "looking for paths in the network with length: 3 for node LATS1 and PTK2B\n", + "looking for paths in the network with length: 4 for node LATS1 and PTK2B\n", + "looking for paths in the network with length: 5 for node LATS1 and PTK2B\n", + "looking for paths in the network with length: 6 for node LATS1 and PTK2B\n", + "Found a path!\n", + "[['LATS1', 'NF2', 'PAK2', 'SRC', 'PTPRH', 'PTK2', 'PTK2B'], ['LATS1', 'STK3', 'RAF1', 'SRC', 'PTPRH', 'PTK2', 'PTK2B'], ['LATS1', 'STK3', 'RAF1', 'LCK', 'PTPRH', 'PTK2', 'PTK2B'], ['LATS1', 'STK4', 'RAF1', 'SRC', 'PTPRH', 'PTK2', 'PTK2B'], ['LATS1', 'STK4', 'RAF1', 'LCK', 'PTPRH', 'PTK2', 'PTK2B']]\n", + "looking for paths in the network with length: 0 for node LATS2 and PTK2B\n", + "looking for paths in the network with length: 1 for node LATS2 and PTK2B\n", + "looking for paths in the network with length: 2 for node LATS2 and PTK2B\n", + "looking for paths in the network with length: 3 for node LATS2 and PTK2B\n", + "looking for paths in the network with length: 4 for node LATS2 and PTK2B\n", + "looking for paths in the network with length: 5 for node LATS2 and PTK2B\n", + "looking for paths in the network with length: 6 for node LATS2 and PTK2B\n", + "Found a path!\n", + "[['LATS2', 'NF2', 'PAK2', 'SRC', 'PTPRH', 'PTK2', 'PTK2B'], ['LATS2', 'STK3', 'RAF1', 'SRC', 'PTPRH', 'PTK2', 'PTK2B'], ['LATS2', 'STK3', 'RAF1', 'LCK', 'PTPRH', 'PTK2', 'PTK2B'], ['LATS2', 'STK4', 'RAF1', 'SRC', 'PTPRH', 'PTK2', 'PTK2B'], ['LATS2', 'STK4', 'RAF1', 'LCK', 'PTPRH', 'PTK2', 'PTK2B']]\n", + "CPU times: user 3min 43s, sys: 217 ms, total: 3min 43s\n", + "Wall time: 3min 43s\n" + ] + } + ], + "source": [ + "%%time\n", + "new_net1.complete_connection(mode=\"ALL\", maxlen=6, k_mean=\"tight\", only_signed=True, connect_node_when_first_introduced=True, consensus=True)" + ] + }, + { + "cell_type": "code", + "execution_count": 6, + "id": "152b9434", + "metadata": {}, + "outputs": [ + { + "data": { + "image/svg+xml": [ + "\n", + "\n", + "\n", + "\n", + "\n", + "\n", + "%3\n", + "\n", + "\n", + "\n", + "SRC\n", + "\n", + "SRC\n", + "\n", + "\n", + "\n", + "PTK2\n", + "\n", + "PTK2\n", + "\n", + "\n", + "\n", + "SRC->PTK2\n", + "\n", + "\n", + "\n", + "\n", + "\n", + "CDH2\n", + "\n", + "CDH2\n", + "\n", + "\n", + "\n", + "SRC->CDH2\n", + "\n", + "\n", + "\n", + "\n", + "\n", + "\n", + "PTK2B\n", + "\n", + "PTK2B\n", + "\n", + "\n", + "\n", + "SRC->PTK2B\n", + "\n", + "\n", + "\n", + "\n", + "\n", + "DAB1\n", + "\n", + "DAB1\n", + "\n", + "\n", + "\n", + "SRC->DAB1\n", + "\n", + "\n", + "\n", + "\n", + "\n", + "CTNNB1\n", + "\n", + "CTNNB1\n", + "\n", + "\n", + "\n", + "SRC->CTNNB1\n", + "\n", + "\n", + "\n", + "\n", + "\n", + "CTNND1\n", + "\n", + "CTNND1\n", + "\n", + "\n", + "\n", + "SRC->CTNND1\n", + "\n", + "\n", + "\n", + "\n", + "\n", + "PRKD1\n", + "\n", + "PRKD1\n", + "\n", + "\n", + "\n", + "SRC->PRKD1\n", + "\n", + "\n", + "\n", + "\n", + "\n", + "MET\n", + "\n", + "MET\n", + "\n", + "\n", + "\n", + "SRC->MET\n", + "\n", + "\n", + "\n", + "\n", + "\n", + "\n", + "PAK2\n", + "\n", + "PAK2\n", + "\n", + "\n", + "\n", + "SRC->PAK2\n", + "\n", + "\n", + "\n", + "\n", + "\n", + "RAF1\n", + "\n", + "RAF1\n", + "\n", + "\n", + "\n", + "SRC->RAF1\n", + "\n", + "\n", + "\n", + "\n", + "\n", + "BCAR1\n", + "\n", + "BCAR1\n", + "\n", + "\n", + "\n", + "SRC->BCAR1\n", + "\n", + "\n", + "\n", + "\n", + "\n", + "EGFR\n", + "\n", + "EGFR\n", + "\n", + "\n", + "\n", + "SRC->EGFR\n", + "\n", + "\n", + "\n", + "\n", + "\n", + "PTK2->BCAR1\n", + "\n", + "\n", + "\n", + "\n", + "\n", + "PTPRH\n", + "\n", + "PTPRH\n", + "\n", + "\n", + "\n", + "PTK2->PTPRH\n", + "\n", + "\n", + "\n", + "\n", + "\n", + "\n", + "CDH2->CTNNB1\n", + "\n", + "\n", + "\n", + "\n", + "\n", + "PTK2B->PTK2\n", + "\n", + "\n", + "\n", + "\n", + "\n", + "PTK2B->EGFR\n", + "\n", + "\n", + "\n", + "\n", + "\n", + "NOTCH1\n", + "\n", + "NOTCH1\n", + "\n", + "\n", + "\n", + "DAB1->NOTCH1\n", + "\n", + "\n", + "\n", + "\n", + "\n", + "CTNNB1->NOTCH1\n", + "\n", + "\n", + "\n", + "\n", + "\n", + "CDH1\n", + "\n", + "CDH1\n", + "\n", + "\n", + "\n", + "CDH1->CTNNB1\n", + "\n", + "\n", + "\n", + "\n", + "\n", + "CDH1->EGFR\n", + "\n", + "\n", + "\n", + "\n", + "\n", + "CTNND1->CDH2\n", + "\n", + "\n", + "\n", + "\n", + "\n", + "CTNND1->CDH1\n", + "\n", + "\n", + "\n", + "\n", + "\n", + "PRKD1->CTNNB1\n", + "\n", + "\n", + "\n", + "\n", + "\n", + "PRKD1->CDH1\n", + "\n", + "\n", + "\n", + "\n", + "\n", + "PRKD1->EGFR\n", + "\n", + "\n", + "\n", + "\n", + "\n", + "MET->PTK2\n", + "\n", + "\n", + "\n", + "\n", + "\n", + "MET->CDH1\n", + "\n", + "\n", + "\n", + "\n", + "\n", + "VIM\n", + "\n", + "VIM\n", + "\n", + "\n", + "\n", + "PAK2->VIM\n", + "\n", + "\n", + "\n", + "\n", + "\n", + "\n", + "PAK2->RAF1\n", + "\n", + "\n", + "\n", + "\n", + "\n", + "NF2\n", + "\n", + "NF2\n", + "\n", + "\n", + "\n", + "PAK2->NF2\n", + "\n", + "\n", + "\n", + "\n", + "\n", + "MAPK8\n", + "\n", + "MAPK8\n", + "\n", + "\n", + "\n", + "MAPK8->SRC\n", + "\n", + "\n", + "\n", + "\n", + "\n", + "STK4\n", + "\n", + "STK4\n", + "\n", + "\n", + "\n", + "MAPK8->STK4\n", + "\n", + "\n", + "\n", + "\n", + "\n", + "SMAD3\n", + "\n", + "SMAD3\n", + "\n", + "\n", + "\n", + "MAPK8->SMAD3\n", + "\n", + "\n", + "\n", + "\n", + "\n", + "MAP3K1\n", + "\n", + "MAP3K1\n", + "\n", + "\n", + "\n", + "MAP3K1->MAPK8\n", + "\n", + "\n", + "\n", + "\n", + "\n", + "MAP4K4\n", + "\n", + "MAP4K4\n", + "\n", + "\n", + "\n", + "MAP4K4->MAP3K1\n", + "\n", + "\n", + "\n", + "\n", + "\n", + "MAP3K7\n", + "\n", + "MAP3K7\n", + "\n", + "\n", + "\n", + "MAP4K4->MAP3K7\n", + "\n", + "\n", + "\n", + "\n", + "\n", + "MAP3K7->MAPK8\n", + "\n", + "\n", + "\n", + "\n", + "\n", + "MAP3K7->SMAD3\n", + "\n", + "\n", + "\n", + "\n", + "\n", + "\n", + "STK3\n", + "\n", + "STK3\n", + "\n", + "\n", + "\n", + "RAF1->STK3\n", + "\n", + "\n", + "\n", + "\n", + "\n", + "\n", + "RAF1->STK4\n", + "\n", + "\n", + "\n", + "\n", + "\n", + "\n", + "LATS1\n", + "\n", + "LATS1\n", + "\n", + "\n", + "\n", + "STK3->LATS1\n", + "\n", + "\n", + "\n", + "\n", + "\n", + "LATS2\n", + "\n", + "LATS2\n", + "\n", + "\n", + "\n", + "STK3->LATS2\n", + "\n", + "\n", + "\n", + "\n", + "\n", + "WWTR1\n", + "\n", + "WWTR1\n", + "\n", + "\n", + "\n", + "LATS1->WWTR1\n", + "\n", + "\n", + "\n", + "\n", + "\n", + "\n", + "YAP1\n", + "\n", + "YAP1\n", + "\n", + "\n", + "\n", + "LATS1->YAP1\n", + "\n", + "\n", + "\n", + "\n", + "\n", + "STK4->LATS1\n", + "\n", + "\n", + "\n", + "\n", + "\n", + "STK4->LATS2\n", + "\n", + "\n", + "\n", + "\n", + "\n", + "NF2->STK3\n", + "\n", + "\n", + "\n", + "\n", + "\n", + "NF2->LATS1\n", + "\n", + "\n", + "\n", + "\n", + "\n", + "NF2->STK4\n", + "\n", + "\n", + "\n", + "\n", + "\n", + "NF2->LATS2\n", + "\n", + "\n", + "\n", + "\n", + "\n", + "LATS2->WWTR1\n", + "\n", + "\n", + "\n", + "\n", + "\n", + "\n", + "LATS2->YAP1\n", + "\n", + "\n", + "\n", + "\n", + "\n", + "\n", + "SMAD3->NOTCH1\n", + "\n", + "\n", + "\n", + "\n", + "\n", + "RUNX2\n", + "\n", + "RUNX2\n", + "\n", + "\n", + "\n", + "SMAD3->RUNX2\n", + "\n", + "\n", + "\n", + "\n", + "\n", + "\n", + "BCAR1->SMAD3\n", + "\n", + "\n", + "\n", + "\n", + "\n", + "\n", + "LCK\n", + "\n", + "LCK\n", + "\n", + "\n", + "\n", + "LCK->NOTCH1\n", + "\n", + "\n", + "\n", + "\n", + "\n", + "LCK->RAF1\n", + "\n", + "\n", + "\n", + "\n", + "\n", + "PTPRH->SRC\n", + "\n", + "\n", + "\n", + "\n", + "\n", + "\n", + "PTPRH->PTK2\n", + "\n", + "\n", + "\n", + "\n", + "\n", + "\n", + "PTPRH->BCAR1\n", + "\n", + "\n", + "\n", + "\n", + "\n", + "\n", + "PTPRH->LCK\n", + "\n", + "\n", + "\n", + "\n", + "\n", + "\n", + "WWTR1->SMAD3\n", + "\n", + "\n", + "\n", + "\n", + "\n", + "WWTR1->RUNX2\n", + "\n", + "\n", + "\n", + "\n", + "\n", + "RUNX2->NOTCH1\n", + "\n", + "\n", + "\n", + "\n", + "\n", + "\n", + "YAP1->CTNNB1\n", + "\n", + "\n", + "\n", + "\n", + "\n", + "YAP1->RUNX2\n", + "\n", + "\n", + "\n", + "\n", + "\n", + "\n", + "EGFR->PTK2\n", + "\n", + "\n", + "\n", + "\n", + "\n", + "EGFR->CTNNB1\n", + "\n", + "\n", + "\n", + "\n", + "\n", + "EGFR->CTNND1\n", + "\n", + "\n", + "\n", + "\n", + "\n", + "\n", + "EGFR->BCAR1\n", + "\n", + "\n", + "\n", + "\n", + "\n", + "\n" + ], + "text/plain": [ + "" + ] + }, + "metadata": {}, + "output_type": "display_data" + } + ], + "source": [ + "#Visualize network\n", + "visualizer1 = NetworkVisualizer(new_net1, color_by='effect')\n", + "visualizer1.render(output_file='network2')" + ] + }, + { + "cell_type": "markdown", + "id": "8ed135d3-9f71-4cec-9381-96c63fba766e", + "metadata": {}, + "source": [ + "### 2. Connect to Gene Ontology (GO) term\n", + "\n", + "Connect the nodes of the Network with markers of a certain phenotype, from Gene Ontology. \n", + "\n", + "The _connect_genes_to_phenotype_ function will look for interactions between the nodes of the network and genes annotated with a GO term of interest. The argument _compress_ replaces the individual phenotype-specific genes into one phenotype node.\n", + "\n", + "We suggest to the users to choose gene ontology terms lower in the hierarcy (e.g., execution phase of apoptosis _versus_ apoptosis) to avoid the inclusion of too many genes." + ] + }, + { + "cell_type": "code", + "execution_count": 7, + "id": "fa499a38-c22a-4a0e-b1d4-3ffb10e4a370", + "metadata": { + "scrolled": true + }, + "outputs": [ + { + "name": "stdout", + "output_type": "stream", + "text": [ + "Start requesting genes from Gene Ontology\n", + "Fetching from: https://golr-aux.geneontology.io/solr/select?defType=edismax&qt=standard&indent=on&wt=csv&rows=100000&start=0&fl=bioentity_label&facet=true&facet.mincount=1&facet.sort=count&json.nl=arrarr&facet.limit=25&hl=true&hl.simple.pre=%3Cem%20class=%22hilite%22%3E&hl.snippets=1000&csv.encapsulator=&csv.separator=%09&csv.header=false&csv.mv.separator=%7C&fq=document_category:%22annotation%22&fq=isa_partof_closure:%22GO:0097194%22&fq=taxon_subset_closure_label:%22Homo%20sapiens%22&fq=type:%22protein%22&fq=annotation_class_label:%22execution%20phase%20of%20apoptosis%22&facet.field=aspect&facet.field=taxon_subset_closure_label&facet.field=type&facet.field=evidence_subset_closure_label&facet.field=regulates_closure_label&facet.field=isa_partof_closure_label&facet.field=annotation_class_label&facet.field=qualifier&facet.field=annotation_extension_class_closure_label&facet.field=assigned_by&facet.field=panther_family_label&q=*:*\n", + "Done\n", + "Starting connecting network's nodes to: ['CASP7', 'STK24', 'COLEC11', 'CFLAR', 'TAOK1', 'AIFM3', 'CECR2', 'CASP4', 'AKT1', 'CASP8', 'BNIP1', 'MADD', 'NPR2', 'NFKBIZ', 'CASP12', 'HTRA2', 'CIDEC', 'CASP2', 'CASP3', 'CASP6', 'CASP5', 'CIDEB', 'BBC3']\n", + "['P12931', 'P46531', 'Q05397', 'P12830', 'P19022', 'P08670', 'O95819', 'O95835', 'Q9NRM7', 'Q14289', 'O75553', 'P35222', 'O60716', 'Q15139', 'P08581', 'Q13177', 'P45983', 'Q13233', 'O43318', 'P04049', 'Q13188', 'Q13043', 'P35240', 'P84022', 'P56945', 'P06239', 'Q9HD43', 'Q9GZV5', 'Q13950', 'P46937', 'P00533']\n", + "['Q9Y6E0', 'O43464', 'Q9BYH8', 'P55210', 'P20594', 'Q9BXF3', 'Q96NN9', 'Q14790', 'P49662', 'P51878', 'Q96AQ7', 'P31749', 'O15519', 'Q8WXG6', 'Q7L7X3', 'Q6UXS9', 'Q9UHD4', 'Q9BWP8', 'Q12981', 'Q96PG8', 'P42575', 'P55212', 'P42574']\n" + ] + }, + { + "ename": "KeyError", + "evalue": "'form_complex'", + "output_type": "error", + "traceback": [ + "\u001b[0;31m---------------------------------------------------------------------------\u001b[0m", + "\u001b[0;31mKeyError\u001b[0m Traceback (most recent call last)", + "File \u001b[0;32m~/anaconda3/envs/omniflow_env/lib/python3.10/site-packages/pandas/core/indexes/base.py:3361\u001b[0m, in \u001b[0;36mIndex.get_loc\u001b[0;34m(self, key, method, tolerance)\u001b[0m\n\u001b[1;32m 3360\u001b[0m \u001b[38;5;28;01mtry\u001b[39;00m:\n\u001b[0;32m-> 3361\u001b[0m \u001b[38;5;28;01mreturn\u001b[39;00m \u001b[38;5;28;43mself\u001b[39;49m\u001b[38;5;241;43m.\u001b[39;49m\u001b[43m_engine\u001b[49m\u001b[38;5;241;43m.\u001b[39;49m\u001b[43mget_loc\u001b[49m\u001b[43m(\u001b[49m\u001b[43mcasted_key\u001b[49m\u001b[43m)\u001b[49m\n\u001b[1;32m 3362\u001b[0m \u001b[38;5;28;01mexcept\u001b[39;00m \u001b[38;5;167;01mKeyError\u001b[39;00m \u001b[38;5;28;01mas\u001b[39;00m err:\n", + "File \u001b[0;32m~/anaconda3/envs/omniflow_env/lib/python3.10/site-packages/pandas/_libs/index.pyx:76\u001b[0m, in \u001b[0;36mpandas._libs.index.IndexEngine.get_loc\u001b[0;34m()\u001b[0m\n", + "File \u001b[0;32m~/anaconda3/envs/omniflow_env/lib/python3.10/site-packages/pandas/_libs/index.pyx:108\u001b[0m, in \u001b[0;36mpandas._libs.index.IndexEngine.get_loc\u001b[0;34m()\u001b[0m\n", + "File \u001b[0;32mpandas/_libs/hashtable_class_helper.pxi:5198\u001b[0m, in \u001b[0;36mpandas._libs.hashtable.PyObjectHashTable.get_item\u001b[0;34m()\u001b[0m\n", + "File \u001b[0;32mpandas/_libs/hashtable_class_helper.pxi:5206\u001b[0m, in \u001b[0;36mpandas._libs.hashtable.PyObjectHashTable.get_item\u001b[0;34m()\u001b[0m\n", + "\u001b[0;31mKeyError\u001b[0m: 'form_complex'", + "\nThe above exception was the direct cause of the following exception:\n", + "\u001b[0;31mKeyError\u001b[0m Traceback (most recent call last)", + "File \u001b[0;32m:1\u001b[0m\n", + "File \u001b[0;32m~/anaconda3/envs/omniflow_env/lib/python3.10/site-packages/omniflow_project/core/network.py:558\u001b[0m, in \u001b[0;36mNetwork.connect_genes_to_phenotype\u001b[0;34m(self, phenotype, id_accession, sub_genes, maxlen, only_signed, compress)\u001b[0m\n\u001b[1;32m 556\u001b[0m unique_uniprot \u001b[38;5;241m=\u001b[39m \u001b[38;5;28mset\u001b[39m(uniprot_genes) \u001b[38;5;241m-\u001b[39m \u001b[38;5;28mset\u001b[39m(nodes)\n\u001b[1;32m 557\u001b[0m unique_uniprot_list \u001b[38;5;241m=\u001b[39m \u001b[38;5;28mlist\u001b[39m(unique_uniprot)\n\u001b[0;32m--> 558\u001b[0m \u001b[38;5;28;43mself\u001b[39;49m\u001b[38;5;241;43m.\u001b[39;49m\u001b[43mconnect_component\u001b[49m\u001b[43m(\u001b[49m\u001b[43mnodes\u001b[49m\u001b[43m,\u001b[49m\u001b[43m \u001b[49m\u001b[43munique_uniprot_list\u001b[49m\u001b[43m,\u001b[49m\u001b[43m \u001b[49m\u001b[43mmode\u001b[49m\u001b[38;5;241;43m=\u001b[39;49m\u001b[38;5;124;43m\"\u001b[39;49m\u001b[38;5;124;43mOUT\u001b[39;49m\u001b[38;5;124;43m\"\u001b[39;49m\u001b[43m,\u001b[49m\u001b[43m \u001b[49m\u001b[43mmaxlen\u001b[49m\u001b[38;5;241;43m=\u001b[39;49m\u001b[43mmaxlen\u001b[49m\u001b[43m,\u001b[49m\u001b[43m \u001b[49m\u001b[43monly_signed\u001b[49m\u001b[38;5;241;43m=\u001b[39;49m\u001b[43monly_signed\u001b[49m\u001b[43m)\u001b[49m\n\u001b[1;32m 560\u001b[0m \u001b[38;5;28;01mif\u001b[39;00m compress:\n\u001b[1;32m 561\u001b[0m \u001b[38;5;28;01mif\u001b[39;00m \u001b[38;5;129;01mnot\u001b[39;00m phenotype \u001b[38;5;129;01mand\u001b[39;00m id_accession:\n", + "File \u001b[0;32m~/anaconda3/envs/omniflow_env/lib/python3.10/site-packages/omniflow_project/core/network.py:508\u001b[0m, in \u001b[0;36mNetwork.connect_component\u001b[0;34m(self, comp_A, comp_B, maxlen, mode, only_signed, consensus)\u001b[0m\n\u001b[1;32m 506\u001b[0m \u001b[38;5;28;01mreturn\u001b[39;00m\n\u001b[1;32m 507\u001b[0m \u001b[38;5;28;01mif\u001b[39;00m only_signed:\n\u001b[0;32m--> 508\u001b[0m paths \u001b[38;5;241m=\u001b[39m \u001b[38;5;28;43mself\u001b[39;49m\u001b[38;5;241;43m.\u001b[39;49m\u001b[43mfilter_unsigned_paths\u001b[49m\u001b[43m(\u001b[49m\u001b[43mpaths\u001b[49m\u001b[43m,\u001b[49m\u001b[43m \u001b[49m\u001b[43mconsensus\u001b[49m\u001b[43m)\u001b[49m\n\u001b[1;32m 509\u001b[0m \u001b[38;5;28mself\u001b[39m\u001b[38;5;241m.\u001b[39madd_paths_to_edge_list(paths, mode)\n\u001b[1;32m 510\u001b[0m all_nodes \u001b[38;5;241m=\u001b[39m \u001b[38;5;28mset\u001b[39m(\u001b[38;5;28mself\u001b[39m\u001b[38;5;241m.\u001b[39mnodes[\u001b[38;5;124m'\u001b[39m\u001b[38;5;124mUniprot\u001b[39m\u001b[38;5;124m'\u001b[39m]\u001b[38;5;241m.\u001b[39mvalues)\n", + "File \u001b[0;32m~/anaconda3/envs/omniflow_env/lib/python3.10/site-packages/omniflow_project/core/network.py:317\u001b[0m, in \u001b[0;36mNetwork.filter_unsigned_paths\u001b[0;34m(self, paths, consensus)\u001b[0m\n\u001b[1;32m 313\u001b[0m interaction_in \u001b[38;5;241m=\u001b[39m interactions\u001b[38;5;241m.\u001b[39mloc[(interactions[\u001b[38;5;124m\"\u001b[39m\u001b[38;5;124msource\u001b[39m\u001b[38;5;124m\"\u001b[39m] \u001b[38;5;241m==\u001b[39m path[i]) \u001b[38;5;241m&\u001b[39m\n\u001b[1;32m 314\u001b[0m (interactions[\u001b[38;5;124m\"\u001b[39m\u001b[38;5;124mtarget\u001b[39m\u001b[38;5;124m\"\u001b[39m] \u001b[38;5;241m==\u001b[39m path[i \u001b[38;5;241m+\u001b[39m \u001b[38;5;241m1\u001b[39m])]\n\u001b[1;32m 315\u001b[0m interaction_out \u001b[38;5;241m=\u001b[39m interactions\u001b[38;5;241m.\u001b[39mloc[(interactions[\u001b[38;5;124m\"\u001b[39m\u001b[38;5;124mtarget\u001b[39m\u001b[38;5;124m\"\u001b[39m] \u001b[38;5;241m==\u001b[39m path[i]) \u001b[38;5;241m&\u001b[39m\n\u001b[1;32m 316\u001b[0m (interactions[\u001b[38;5;124m\"\u001b[39m\u001b[38;5;124msource\u001b[39m\u001b[38;5;124m\"\u001b[39m] \u001b[38;5;241m==\u001b[39m path[i \u001b[38;5;241m+\u001b[39m \u001b[38;5;241m1\u001b[39m])]\n\u001b[0;32m--> 317\u001b[0m \u001b[38;5;28;01mif\u001b[39;00m \u001b[38;5;129;01mnot\u001b[39;00m interaction_in\u001b[38;5;241m.\u001b[39mempty \u001b[38;5;129;01mand\u001b[39;00m \u001b[43mcheck_sign\u001b[49m\u001b[43m(\u001b[49m\u001b[43minteraction_in\u001b[49m\u001b[43m,\u001b[49m\u001b[43m \u001b[49m\u001b[43mconsensus\u001b[49m\u001b[43m)\u001b[49m \u001b[38;5;241m==\u001b[39m \u001b[38;5;124m\"\u001b[39m\u001b[38;5;124mundefined\u001b[39m\u001b[38;5;124m\"\u001b[39m:\n\u001b[1;32m 318\u001b[0m is_full_signed \u001b[38;5;241m=\u001b[39m \u001b[38;5;28;01mFalse\u001b[39;00m\n\u001b[1;32m 319\u001b[0m \u001b[38;5;28;01mif\u001b[39;00m \u001b[38;5;129;01mnot\u001b[39;00m interaction_out\u001b[38;5;241m.\u001b[39mempty \u001b[38;5;129;01mand\u001b[39;00m check_sign(interaction_out, consensus) \u001b[38;5;241m==\u001b[39m \u001b[38;5;124m\"\u001b[39m\u001b[38;5;124mundefined\u001b[39m\u001b[38;5;124m\"\u001b[39m:\n", + "File \u001b[0;32m~/anaconda3/envs/omniflow_env/lib/python3.10/site-packages/omniflow_project/core/network.py:33\u001b[0m, in \u001b[0;36mcheck_sign\u001b[0;34m(interaction, consensus)\u001b[0m\n\u001b[1;32m 31\u001b[0m \u001b[38;5;28;01melif\u001b[39;00m interaction[\u001b[38;5;124m\"\u001b[39m\u001b[38;5;124mis_inhibition\u001b[39m\u001b[38;5;124m\"\u001b[39m]\u001b[38;5;241m.\u001b[39mvalues[\u001b[38;5;241m0\u001b[39m]:\n\u001b[1;32m 32\u001b[0m \u001b[38;5;28;01mreturn\u001b[39;00m \u001b[38;5;124m\"\u001b[39m\u001b[38;5;124minhibition\u001b[39m\u001b[38;5;124m\"\u001b[39m\n\u001b[0;32m---> 33\u001b[0m \u001b[38;5;28;01melif\u001b[39;00m \u001b[43minteraction\u001b[49m\u001b[43m[\u001b[49m\u001b[38;5;124;43m\"\u001b[39;49m\u001b[38;5;124;43mform_complex\u001b[39;49m\u001b[38;5;124;43m\"\u001b[39;49m\u001b[43m]\u001b[49m\u001b[38;5;241m.\u001b[39mvalues[\u001b[38;5;241m0\u001b[39m]:\n\u001b[1;32m 34\u001b[0m \u001b[38;5;28;01mreturn\u001b[39;00m \u001b[38;5;124m\"\u001b[39m\u001b[38;5;124mform complex\u001b[39m\u001b[38;5;124m\"\u001b[39m\n\u001b[1;32m 35\u001b[0m \u001b[38;5;28;01melse\u001b[39;00m:\n", + "File \u001b[0;32m~/anaconda3/envs/omniflow_env/lib/python3.10/site-packages/pandas/core/frame.py:3458\u001b[0m, in \u001b[0;36mDataFrame.__getitem__\u001b[0;34m(self, key)\u001b[0m\n\u001b[1;32m 3456\u001b[0m \u001b[38;5;28;01mif\u001b[39;00m \u001b[38;5;28mself\u001b[39m\u001b[38;5;241m.\u001b[39mcolumns\u001b[38;5;241m.\u001b[39mnlevels \u001b[38;5;241m>\u001b[39m \u001b[38;5;241m1\u001b[39m:\n\u001b[1;32m 3457\u001b[0m \u001b[38;5;28;01mreturn\u001b[39;00m \u001b[38;5;28mself\u001b[39m\u001b[38;5;241m.\u001b[39m_getitem_multilevel(key)\n\u001b[0;32m-> 3458\u001b[0m indexer \u001b[38;5;241m=\u001b[39m \u001b[38;5;28;43mself\u001b[39;49m\u001b[38;5;241;43m.\u001b[39;49m\u001b[43mcolumns\u001b[49m\u001b[38;5;241;43m.\u001b[39;49m\u001b[43mget_loc\u001b[49m\u001b[43m(\u001b[49m\u001b[43mkey\u001b[49m\u001b[43m)\u001b[49m\n\u001b[1;32m 3459\u001b[0m \u001b[38;5;28;01mif\u001b[39;00m is_integer(indexer):\n\u001b[1;32m 3460\u001b[0m indexer \u001b[38;5;241m=\u001b[39m [indexer]\n", + "File \u001b[0;32m~/anaconda3/envs/omniflow_env/lib/python3.10/site-packages/pandas/core/indexes/base.py:3363\u001b[0m, in \u001b[0;36mIndex.get_loc\u001b[0;34m(self, key, method, tolerance)\u001b[0m\n\u001b[1;32m 3361\u001b[0m \u001b[38;5;28;01mreturn\u001b[39;00m \u001b[38;5;28mself\u001b[39m\u001b[38;5;241m.\u001b[39m_engine\u001b[38;5;241m.\u001b[39mget_loc(casted_key)\n\u001b[1;32m 3362\u001b[0m \u001b[38;5;28;01mexcept\u001b[39;00m \u001b[38;5;167;01mKeyError\u001b[39;00m \u001b[38;5;28;01mas\u001b[39;00m err:\n\u001b[0;32m-> 3363\u001b[0m \u001b[38;5;28;01mraise\u001b[39;00m \u001b[38;5;167;01mKeyError\u001b[39;00m(key) \u001b[38;5;28;01mfrom\u001b[39;00m \u001b[38;5;21;01merr\u001b[39;00m\n\u001b[1;32m 3365\u001b[0m \u001b[38;5;28;01mif\u001b[39;00m is_scalar(key) \u001b[38;5;129;01mand\u001b[39;00m isna(key) \u001b[38;5;129;01mand\u001b[39;00m \u001b[38;5;129;01mnot\u001b[39;00m \u001b[38;5;28mself\u001b[39m\u001b[38;5;241m.\u001b[39mhasnans:\n\u001b[1;32m 3366\u001b[0m \u001b[38;5;28;01mraise\u001b[39;00m \u001b[38;5;167;01mKeyError\u001b[39;00m(key)\n", + "\u001b[0;31mKeyError\u001b[0m: 'form_complex'" + ] + } + ], + "source": [ + "%%time\n", + "new_net1.connect_genes_to_phenotype(id_accession=\"GO:0097194\", phenotype=\"execution phase of apoptosis\", only_signed=True, compress=True, maxlen=1)" + ] + }, + { + "cell_type": "code", + "execution_count": 8, + "id": "33300268-bcf6-442b-97be-c7718922a939", + "metadata": { + "scrolled": true + }, + "outputs": [ + { + "data": { + "image/svg+xml": [ + "\n", + "\n", + "\n", + "\n", + "\n", + "\n", + "%3\n", + "\n", + "\n", + "\n", + "SRC\n", + "\n", + "SRC\n", + "\n", + "\n", + "\n", + "PTK2\n", + "\n", + "PTK2\n", + "\n", + "\n", + "\n", + "SRC->PTK2\n", + "\n", + "\n", + "\n", + "\n", + "\n", + "CDH2\n", + "\n", + "CDH2\n", + "\n", + "\n", + "\n", + "SRC->CDH2\n", + "\n", + "\n", + "\n", + "\n", + "\n", + "\n", + "PTK2B\n", + "\n", + "PTK2B\n", + "\n", + "\n", + "\n", + "SRC->PTK2B\n", + "\n", + "\n", + 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"\n", + "\n", + "MAP4K4->MAP3K1\n", + "\n", + "\n", + "\n", + "\n", + "\n", + "MAP3K7\n", + "\n", + "MAP3K7\n", + "\n", + "\n", + "\n", + "MAP4K4->MAP3K7\n", + "\n", + "\n", + "\n", + "\n", + "\n", + "MAP3K7->MAPK8\n", + "\n", + "\n", + "\n", + "\n", + "\n", + "MAP3K7->SMAD3\n", + "\n", + "\n", + "\n", + "\n", + "\n", + "\n", + "STK3\n", + "\n", + "STK3\n", + "\n", + "\n", + "\n", + "RAF1->STK3\n", + "\n", + "\n", + "\n", + "\n", + "\n", + "\n", + "RAF1->STK4\n", + "\n", + "\n", + "\n", + "\n", + "\n", + "\n", + "LATS1\n", + "\n", + "LATS1\n", + "\n", + "\n", + "\n", + "STK3->LATS1\n", + "\n", + "\n", + "\n", + "\n", + "\n", + "LATS2\n", + "\n", + "LATS2\n", + "\n", + "\n", + "\n", + "STK3->LATS2\n", + "\n", + "\n", + "\n", + "\n", + "\n", + "WWTR1\n", + "\n", + "WWTR1\n", + "\n", + "\n", + "\n", + "LATS1->WWTR1\n", + "\n", + "\n", + "\n", + "\n", + "\n", + "\n", + "YAP1\n", + "\n", + "YAP1\n", + "\n", + "\n", + "\n", + "LATS1->YAP1\n", + "\n", + "\n", + "\n", + "\n", + "\n", + "STK4->LATS1\n", + "\n", + "\n", + "\n", + "\n", + "\n", + "STK4->LATS2\n", + "\n", + "\n", + "\n", + "\n", + "\n", + "NF2->STK3\n", + "\n", + "\n", + "\n", + "\n", + "\n", + "NF2->LATS1\n", + "\n", + "\n", + "\n", + "\n", + "\n", + "NF2->STK4\n", + "\n", + "\n", + "\n", + "\n", + "\n", + "NF2->LATS2\n", + "\n", + "\n", + "\n", + "\n", + "\n", + "LATS2->WWTR1\n", + "\n", + "\n", + "\n", + "\n", + "\n", + "\n", + "LATS2->YAP1\n", + "\n", + "\n", + "\n", + "\n", + "\n", + "\n", + "SMAD3->NOTCH1\n", + "\n", + "\n", + "\n", + "\n", + "\n", + "RUNX2\n", + "\n", + "RUNX2\n", + "\n", + "\n", + "\n", + "SMAD3->RUNX2\n", + "\n", + "\n", + "\n", + "\n", + "\n", + "\n", + "BCAR1->SMAD3\n", + "\n", + "\n", + "\n", + "\n", + "\n", + "\n", + "LCK\n", + "\n", + "LCK\n", + "\n", + "\n", + "\n", + "LCK->NOTCH1\n", + "\n", + "\n", + "\n", + "\n", + "\n", + "LCK->RAF1\n", + "\n", + "\n", + "\n", + "\n", + "\n", + "PTPRH->SRC\n", + "\n", + "\n", + "\n", + "\n", + "\n", + "\n", + "PTPRH->PTK2\n", + "\n", + "\n", + "\n", + "\n", + "\n", + "\n", + "PTPRH->BCAR1\n", + "\n", + "\n", + "\n", + "\n", + "\n", + "\n", + "PTPRH->LCK\n", + "\n", + "\n", + "\n", + "\n", + "\n", + "\n", + "WWTR1->SMAD3\n", + "\n", + "\n", + "\n", + "\n", + "\n", + "WWTR1->RUNX2\n", + "\n", + "\n", + "\n", + "\n", + "\n", + "RUNX2->NOTCH1\n", + "\n", + "\n", + "\n", + "\n", + "\n", + "\n", + "YAP1->CTNNB1\n", + "\n", + "\n", + "\n", + "\n", + "\n", + "YAP1->RUNX2\n", + "\n", + "\n", + "\n", + "\n", + "\n", + "\n", + "EGFR->PTK2\n", + "\n", + "\n", + "\n", + "\n", + "\n", + "EGFR->CTNNB1\n", + "\n", + "\n", + "\n", + "\n", + "\n", + "EGFR->CTNND1\n", + "\n", + "\n", + "\n", + "\n", + "\n", + "\n", + "EGFR->BCAR1\n", + "\n", + "\n", + "\n", + "\n", + "\n", + "\n" + ], + "text/plain": [ + "" + ] + }, + "metadata": {}, + "output_type": "display_data" + } + ], + "source": [ + "#Visualize network\n", + "visualizer1 = NetworkVisualizer(new_net1, color_by='effect')\n", + "visualizer1.render(output_file='network2')" + ] + } + ], + "metadata": { + "kernelspec": { + "display_name": "Python 3 (ipykernel)", + "language": "python", + "name": "python3" + }, + "language_info": { + "codemirror_mode": { + "name": "ipython", + "version": 3 + }, + "file_extension": ".py", + "mimetype": "text/x-python", + "name": "python", + "nbconvert_exporter": "python", + "pygments_lexer": "ipython3", + "version": "3.10.13" + } + }, + "nbformat": 4, + "nbformat_minor": 5 +} From 39a00df8fc4544a0cfd62872d49903195d59eb8c Mon Sep 17 00:00:00 2001 From: Eirinits Date: Thu, 4 Apr 2024 11:53:07 +0200 Subject: [PATCH 10/10] add phosphositeplus data files --- .../_data/Kinase_Substrate_Dataset | 23381 ++++++++++++++++ omniflow_project/_data/Regulatory_sites | 20194 +++++++++++++ 2 files changed, 43575 insertions(+) create mode 100644 omniflow_project/_data/Kinase_Substrate_Dataset create mode 100644 omniflow_project/_data/Regulatory_sites diff --git a/omniflow_project/_data/Kinase_Substrate_Dataset b/omniflow_project/_data/Kinase_Substrate_Dataset new file mode 100644 index 0000000..0f4691a --- /dev/null +++ b/omniflow_project/_data/Kinase_Substrate_Dataset @@ -0,0 +1,23381 @@ +GENE KINASE KIN_ACC_ID KIN_ORGANISM SUBSTRATE SUB_GENE_ID SUB_ACC_ID SUB_GENE SUB_ORGANISM SUB_MOD_RSD SITE_GRP_ID SITE_+/-7_AA DOMAIN IN_VIVO_RXN IN_VITRO_RXN CST_CAT# +Dyrk2 DYRK2 Q5U4C9 mouse NDEL1 83431 Q9ERR1 Ndel1 mouse S336 1869686801 LGSsRPSsAPGMLPL X +Pak2 PAK2 Q64303 rat MEK1 170851 Q01986 Map2k1 rat S298 448284 RtPGRPLsSYGMDSR Pkinase X 9128; 98195 +Pak2 PAK2 Q64303 rat PRKD1 85421 Q9WTQ1 Prkd1 rat S203 449896 GVRRRRLsNVsLTGL X +Pak2 PAK2 Q64303 rat prolactin 24683 P01237 Prl rat S206 451732 IRCLRRDsHKVDNYL Hormone_1 X +Pak2 PAK2 Q64303 rat prolactin 5617 P01236 PRL human S207 451732 LHCLRRDsHKIDNYL Hormone_1 X +EIF2AK1 HRI Q9BQI3 human eIF2-alpha 54318 P68101 Eif2s1 rat S52 447635 MILLSELsRRRIRSI S1 X 3597; 9721; 3398; 5199; 53085; 95797 +EIF2AK1 HRI Q9BQI3 human eIF2-alpha 100339093 P83268 EIF2S1 rabbit S51 447635 RILLsELsR______ S1 X 3398; 5199; 95797 +EIF2AK1 HRI Q9BQI3 human eIF2-alpha 1965 P05198 EIF2S1 human S52 447635 MILLsELsRRRIRsI S1 X 3597; 9721; 3398; 5199; 53085; 95797 +EIF2AK1 HRI Q9BQI3 human eIF2-alpha 1965 P05198 EIF2S1 human S49 450210 IEGMILLsELsRRRI S1 X +PRKCD PKCD Q05655 human syndecan-4 24771 P34901 Sdc4 rat S183 449863 MKKKDEGsYDLGKKP Syndecan X X +PRKCD PKCD Q05655 human ANKRD54 223690 Q91WK7 Ankrd54 mouse S14 239773904 GADDESRsGRsssDG X +PRKCD PKCD Q05655 human HDAC5 10014 Q9UQL6 HDAC5 human S259 447995 FPLRkTAsEPNLKVR X 3443 +PRKCD PKCD Q05655 human PTPRA iso6 5786 P18433-2 PTPRA human S204 447612 PLLARSPsTNRKYPP X +PRKCD PKCD Q05655 human Bcl-2 596 P10415 BCL2 human S70 448395 RDPVARtsPLQtPAA X 2834; 2827 +PRKCD PKCD Q05655 human hnRNP K 3190 P61978 HNRNPK human S302 457408 GrGGrGGsrArNLPL X X +PRKCD PKCD Q05655 human NHE1 6548 P19634 SLC9A1 human S648 3880766 KTRQRLRsYNRHtLV NEXCaM_BD X +PRKCD PKCD Q05655 human SHOC2 8036 Q9UQ13 SHOC2 human T71 34669125 VAFSVDNtIKRPNPA X +PRKCD PKCD Q05655 human TNNI3 21954 P48787 Tnni3 mouse T144 451483 RGKFKRPtLRRVRIs Troponin X +PRKCD PKCD Q05655 human IRS1 25467 P35570 Irs1 rat S612 447562 DDGyMPMsPGVAPVP X 3193; 2386; 3203 +PRKCD PKCD Q05655 human BVR 644 P53004 BLVRA human S237 4774274 sFHFksGsLENVPNV Biliv-reduc_cat X X +PRKCD PKCD Q05655 human MUC1 4582 P15941 MUC1 human T1224 455682 RyVPPsstDRsPyEK X X +PRKCD PKCD Q05655 human ADD1 118 P35611 ADD1 human S726 449829 KKKFRtPsFLKKsKK X X +PRKCD PKCD Q05655 human TNNT2 286816 P13789 TNNT2 cow T191 449038 GYIQKAQtERKsGKR Troponin X +PRKCD PKCD Q05655 human p47phox 653361 P14598 NCF1 human S370 451730 PAVPPRPsADLILNR p47_phox_C X +PRKCD PKCD Q05655 human IRS1 25467 P35570 Irs1 rat S307 447558 TEsITATsPASMVGG X 2381 +PRKCD PKCD Q05655 human FBXO25 26260 Q8TCJ0 FBXO25 human S178 37043701 DLLQDLSsTLCILIR X X +PRKCD PKCD Q05655 human ENOX2 10495 Q16206 ENOX2 human S504 25602101 ENLKEKEsCASRLCA X X +PRKCD PKCD Q05655 human DRP1 114114 O35303 Dnm1l rat S635 454690 PIPIMPAsPQKGHAV X X 3455; 4494; 63940 +PRKCD PKCD Q05655 human MARK2 2011 Q7KZI7 MARK2 human T596 453427 rGVssRstFHAGQLR X X +PRKCD PKCD Q05655 human MYBPC3 17868 O70468 Mybpc3 mouse S302 471081 sLLKKRDsFRRDskL X +PRKCD PKCD Q05655 human TNNI3 7137 P19429 TNNI3 human T143 451483 RGKFKRPtLRrVrIs Troponin X +PRKCD PKCD Q05655 human FRA1 8061 P15407 FOSL1 human T217 1270902 LEPEALHtPTLMTtP X +PRKCD PKCD Q05655 human BEST1 7439 O76090 BEST1 human S358 9720901 SAQFRRAsFMGSTFN X +PRKCD PKCD Q05655 human P70S6KB 6199 Q9UBS0 RPS6KB2 human S473 450071 PPSGTKKsKRGRGRP X X +PRKCD PKCD Q05655 human p40phox 4689 Q15080 NCF4 human S315 448265 RQARGLPsQKRLFPW PB1 X +PRKCD PKCD Q05655 human p47phox 653361 P14598 NCF1 human S303 449405 RGAPPRRssIRNAHs NECFESHC X +PRKCD PKCD Q05655 human CARD9 64170 Q9H257 CARD9 human T231 23017301 CKVERKHtLKLRHAM X X +PRKCD PKCD Q05655 human RGS9 281453 O46469 RGS9 cow S475 449027 MSKLDRRsQLRKEPP X +PRKCD PKCD Q05655 human ITGB2 3689 P05107 ITGB2 human T758 448533 NPLFksAtttVMNPk Integrin_b_cyt X +PRKCD PKCD Q05655 human PKCD 5580 Q05655 PRKCD human T218 7445829 TAANSRDtIFQkERF X +PRKCD PKCD Q05655 human TRPV4 59341 Q9HBA0 TRPV4 human S162 10272403 FDIVSRGsTADLDGL X +PRKCD PKCD Q05655 human L-plastin 3936 P13796 LCP1 human S5 450852 ___MARGsVsDEEMM X +PRKCD PKCD Q05655 human SQSTM1 8878 Q13501 SQSTM1 human S349 14580829 sskEVDPstGELQsL X X 95697; 16177; 12074 +PRKCD PKCD Q05655 human K8 3856 P05787 KRT8 human S74 448539 tVNQsLLsPLVLEVD Keratin_2_head X +PRKCD PKCD Q05655 human GAPDH 2597 P04406 GAPDH human T246 23109023 NVsVVDLtCrLEkPA Gp_dh_C X X +PRKCD PKCD Q05655 human GAPDH 2597 P04406 GAPDH human S241 9425118 rVPtANVsVVDLtCr Gp_dh_C X +PRKCD PKCD Q05655 human NRG1 iso6 3084 Q02297-6 NRG1 human S286 28076401 LHDRLRQsLRSERNN Neuregulin X +PRKCD PKCD Q05655 human p47phox 653361 P14598 NCF1 human S328 449404 QDAYRRNsVRFLQQR NECFESHC X +PRKCD PKCD Q05655 human DAP3 7818 P51398 DAP3 human S31 2226208 MGTQARQsIAAHLDN X +PRKCD PKCD Q05655 human STAT1 6772 P42224 STAT1 human S727 447753 TDNLLPMsPEEFDEV STAT1_TAZ2bind X 9177; 8826; 62390 +PRKCD PKCD Q05655 human p40phox 4689 Q15080 NCF4 human T154 448266 LRRLRPRtRKVKSVs X 4311 +PRKCD PKCD Q05655 human PKCD 5580 Q05655 PRKCD human S503 4270924 kENIFGEsRAstFCG Pkinase X +PRKCD PKCD Q05655 human PPAR-alpha 25747 P37230 Ppara rat T129 457548 CKGFFRRtIRLKLAY zf-C4 X +PRKCD PKCD Q05655 human S6 6194 P62753 RPS6 human S235 448092 IAKRRRLssLRAsts X 5006; 4856; 4857; 4858; 4851; 4803; 2211; 3945; 3985; 5316; 4854; 8520; 48319; 40643; 9865; 38573; 14733; 27036; 34411; 62016; 62788; 81736; 97935; 99457; 15448 +PRKCD PKCD Q05655 human ITGB2 3689 P05107 ITGB2 human S745 448532 FEkEKLksQWNNDNP Integrin_b_cyt X +PRKCD PKCD Q05655 human DBI 100008823 Q8WN94 DBI rabbit T65 2833502 AWNELKGtSKESAMR ACBP X +PRKCD PKCD Q05655 human PKCD 5580 Q05655 PRKCD human S299 483986 NQVtQRAsRRsDsAs X X +PRKCD PKCD Q05655 human SLC29A1 2030 Q99808 SLC29A1 human S281 21326706 QPTNESHsIkAILkN Nucleoside_tran X +PRKCD PKCD Q05655 human PPAR-alpha 25747 P37230 Ppara rat S110 457547 RICGDKAsGYHYGVH zf-C4 X +PRKCD PKCD Q05655 human TIRAP 114609 P58753 TIRAP human Y106 463809 AAQDLVSyLEGSTAS TIR_2 X +PRKCD PKCD Q05655 human TNNT2 286816 P13789 TNNT2 cow T200 451556 RKsGKRQtEREKKKK Troponin X +PRKCD PKCD Q05655 human DAP3 7818 P51398 DAP3 human S280 2226203 tLKREDksPIAPEEL DAP3 X +PRKCD PKCD Q05655 human Cortactin 2017 Q14247 CTTN human S405 447700 KtQtPPVsPAPQPtE X +PRKCD PKCD Q05655 human DAB2 1601 P98082 DAB2 human S24 451211 QAAPKAPsKKEKKKG X +PRKCD PKCD Q05655 human PTPN22 26191 Q9Y2R2 PTPN22 human S35 1725300 FLkLkRQsTKYKADK X X +PRKCD PKCD Q05655 human PRKD1 5587 Q15139 PRKD1 human S742 448590 GEksFRRsVVGtPAy Pkinase X X +PRKCD PKCD Q05655 human PKCD 5580 Q05655 PRKCD human S302 478497 tQRAsRRsDsAssEP X +PRKCD PKCD Q05655 human p47phox 653361 P14598 NCF1 human S348 451728 PGPQsPGsPLEEERQ X X +PRKCD PKCD Q05655 human eNOS 287024 P29473 NOS3 cow S1179 447884 TSRIRtQsFsLQERH X 9570 +PRKCD PKCD Q05655 human BVR 644 P53004 BLVRA human S230 478716 LKRNRyLsFHFksGs Biliv-reduc_cat X X +PRKCD PKCD Q05655 human PKCD 5580 Q05655 PRKCD human S645 448591 LNEkARLsysDKNLI Pkinase_C X 9376 +PRKCD PKCD Q05655 human CACNA1C 100101555 P15381 CACB rabbit S1674 480102 QGLVGKPsQRNALSL X +PRKCD PKCD Q05655 human HMGA1 117062 Q8K585 Hmga1 rat S44 479856 PGTALVGsQKEPSEV X +PRKCD PKCD Q05655 human TNNI3 511094 P08057 TNNI3 cow S24 448423 PPPVRRRssANYRAY Troponin-I_N X +PRKCD PKCD Q05655 human DAP3 7818 P51398 DAP3 human T237 2226209 ItRVRNAtDAVGIVL DAP3 X +PRKCD PKCD Q05655 human PKCD 5580 Q05655 PRKCD human S304 483987 RAsRRsDsAssEPVG X X +PRKCD PKCD Q05655 human FGF1 2246 P05230 FGF1 human S131 31954800 VGLKKNGsCKRGPRT FGF X X +PRKCD PKCD Q05655 human PKCD 5580 Q05655 PRKCD human T295 4272376 AEALNQVtQRAsRRs X +PRKCD PKCD Q05655 human NRF2 18024 Q60795 Nfe2l2 mouse S40 450082 SREVFDFsQRQKDYE X +PRKCD PKCD Q05655 human AML3 12393 Q08775 Runx2 mouse S326 460575 KLDDSKPsLFSDRLS X +PRKCD PKCD Q05655 human SMPD1 6609 P17405 SMPD1 human S510 477185 DGNYSGSsHVVLDHE ASMase_C X X +PRKCD PKCD Q05655 human H3 8350 P68431 H3C1 human T45 455679 PHryrPGtVALrEIR Histone X X +PRKCD PKCD Q05655 human CHAT iso3 1103 P28329-3 CHAT human S476 454037 HKAAVPAsEKLLLLK Carn_acyltransf X +PRKCD PKCD Q05655 human CYBA 1535 P13498 CYBA human T147 7103047 ERPQIGGtIkQPPsN Cytochrom_B558a X +PRKCD PKCD Q05655 human PTPRA iso6 5786 P18433-2 PTPRA human S180 447611 QAGSHSNsFRLSNGR X +PRKCD PKCD Q05655 human p53 7157 P04637 TP53 human S46 447536 AMDDLMLsPDDIEQW TAD2 X X 2521 +PRKCD PKCD Q05655 human PR 5241 P06401 PGR human S400 449842 GAEAsARsPRSYLVA Prog_receptor X +PRKCD PKCD Q05655 human PREX1 57580 Q8TCU6 PREX1 human S313 18704701 RVtGsKKsTKRTKsI X X +PRKCD PKCD Q05655 human TACE 6868 P78536 ADAM17 human T735 449804 kPFPAPQtPGRLQPA X +PRKCD PKCD Q05655 human Ebp1 288778 Q6AYD3 Pa2g4 rat S360 478276 ELKALLQsSASRKTQ X +PRKCD PKCD Q05655 human CDH1 999 P12830 CDH1 human T790 55578700 TRNDVAPtLMsVPRy X X +PRKCD PKCD Q05655 human ANKRD54 223690 Q91WK7 Ankrd54 mouse S19 239773906 SRsGRsssDGECAVA X +PRKCD PKCD Q05655 human C5aR 728 P21730 C5AR1 human S334 448819 sVVREsKsFTRsTVD X +PRKCD PKCD Q05655 human IRS1 3667 P35568 IRS1 human S574 451681 RLPGHRHsAFVPTRs X +PRKCD PKCD Q05655 human PLSCR3 57048 Q9NRY6 PLSCR3 human T21 457790 PPPPYPVtPGYPEPA X X +PRKCD PKCD Q05655 human GLRB 14658 P48168 Glrb mouse S425 2048205 NDFSIVGsLPRDFEL Neur_chan_memb X +PRKCD PKCD Q05655 human NADK 65220 O95544 NADK human S46 1210510 RGRAKsrsLsAsPAL X +PRKCD PKCD Q05655 human TNNI3 511094 P08057 TNNI3 cow S79 451839 GEKGRALsTRCQPLE Troponin X +PRKCD PKCD Q05655 human TRPV4 59341 Q9HBA0 TRPV4 human T175 10272405 GLLPFLLtHKKRLTD X +PRKCD PKCD Q05655 human DBI 100008823 Q8WN94 DBI rabbit T42 2833500 AtVGDVNtERPGMLD ACBP X +PRKCD PKCD Q05655 human IRS1 25467 P35570 Irs1 rat S24 455604 GYLRKPKsMHKRFFV PH X +PRKCD PKCD Q05655 human PPP1R14A 94274 Q96A00 PPP1R14A human T38 449098 QkRHARVtVkYDRRE PP1_inhibitor X +PRKCD PKCD Q05655 human p47phox 653361 P14598 NCF1 human S320 451726 QRsRKRLsQDAYRRN NECFESHC X +PRKCD PKCD Q05655 human p47phox 653361 P14598 NCF1 human S359 451729 EERQtQRsKPQPAVP p47_phox_C X +PRKCD PKCD Q05655 human TNNI3 511094 P08057 TNNI3 cow S44 450690 AKKKSKIsAsRKLQL X +PRKCD PKCD Q05655 human G6PD iso3 2539 P11413-3 G6PD human S210 15207801 FGRDLQSsDRLSNHI G6PD_N X X +PRKCD PKCD Q05655 human CACNA1C 100101555 P15381 CACB rabbit S1928 455278 ASLGRRAsFHLECLK CAC1F_C X +PRKCD PKCD Q05655 human NADK 65220 O95544 NADK human S64 467326 kEFRRtRsLHGPCPV X +PRKCD PKCD Q05655 human CDK5 1020 Q00535 CDK5 human T77 900975700 LHsDkKLtLVFEFCD Pkinase X +PRKCD PKCD Q05655 human LIMK2 3985 P53671 LIMK2 human S283 456167 EGtLRRRsLRRsNsI X X +PRKCD PKCD Q05655 human TNNT2 286816 P13789 TNNT2 cow T281 451557 TRGKAKVtGRWK___ X +PRKCD PKCD Q05655 human TNNI3 511094 P08057 TNNI3 cow T145 451483 RGKFKRPtLRRVRIS Troponin X +PRKCD PKCD Q05655 human DAP3 7818 P51398 DAP3 human S185 2226206 FDQPLEAstWLkNFk DAP3 X +PRKCD PKCD Q05655 human EAR-2 2063 P10588 NR2F6 human S83 25802106 CKSFFKRsIRRNLsY zf-C4 X +PRKCD PKCD Q05655 human PIP5K1B 18719 P70181 Pip5k1b mouse S413 27461455 PSKKRCNsIAALKAT X +PRKCD PKCD Q05655 human p47phox 653361 P14598 NCF1 human S304 449406 GAPPRRssIRNAHsI NECFESHC X X +PRKCD PKCD Q05655 human NMDAR2B 24410 Q00960 Grin2b rat S1303 450171 NKLRRQHsyDtFVDL NMDAR2_C X 20274; 71335 +PRKCD PKCD Q05655 human HVCN1 iso4 84329 Q96D96-4 HVCN1 human S77 12064203 GMLRKLFsSHRFQVI X +PRKCD PKCD Q05655 human CACNA1C 100101555 P15381 CACB rabbit S528 486358 ARLAHRIsKSKFsRY X +PRKCD PKCD Q05655 human TNNI3 7137 P19429 TNNI3 human S23 448423 PAPIRRRssNyRAyA Troponin-I_N X 4004 +PRKCD PKCD Q05655 human IRS1 3667 P35568 IRS1 human S323 451399 MVGGKPGsFRVRAss X 5610 +PRKCD PKCD Q05655 human gp130 3572 P40189 IL6ST human T890 455688 GQVERFEtVGMEAAt X X +PRKCD PKCD Q05655 human TAGLN 25123 P31232 Tagln rat S181 469978 VIGLQMGsNrGAsQA Calponin X +PRKCD PKCD Q05655 human DAP3 7818 P51398 DAP3 human T186 2226207 DQPLEAstWLkNFkT DAP3 X +PRKCD PKCD Q05655 human PKCD 5580 Q05655 PRKCD human T141 1028305 EDEAkFPtMNRRGAI X +PRKCD PKCD Q05655 human RPS3 6188 P23396 RPS3 human S6 8046503 __MAVQIskkRkFVA X X +PRKCD PKCD Q05655 human ANKRD54 223690 Q91WK7 Ankrd54 mouse S17 239773905 DESRsGRsssDGECA X +PRKCD PKCD Q05655 human VRK1 22367 Q80X41 Vrk1 mouse S355 483969 SVKTRPAsKKRKKEA X X +PRKCD PKCD Q05655 human PRKD1 5587 Q15139 PRKD1 human S738 448589 ARIIGEksFRRsVVG Pkinase X X 2054 +PRKCD PKCD Q05655 human PLD2 5338 O14939 PLD2 human T566 15343400 FIQRWNFtKTTKAKy X X +PRKCD PKCD Q05655 human BAG3 9531 O95817 BAG3 human S187 12217052 sSSSSSAsLPsSGRs X X +PRKCD PKCD Q05655 human MCU 90550 Q8NE86 MCU human S92 27259017 VISVRLPsRRERCQF X +PRKCD PKCD Q05655 human CHAT iso3 1103 P28329-3 CHAT human S440 449057 VPTYESAsIRRFQEG Carn_acyltransf X +PRKCD PKCD Q05655 human FRA1 8061 P15407 FOSL1 human T227 50205700 LMTtPSLtPFtPSLV X +PRKCD PKCD Q05655 human HMGA1 117062 Q8K585 Hmga1 rat S64 3136103 PRGRPKGsKNKGTAK X +PRKCD PKCD Q05655 human SHC1 iso2 6464 P29353-2 SHC1 human S29 448791 EEWTRHGsFVNKPTR X X +PRKCD PKCD Q05655 human EGFR 1956 P00533 EGFR human T678 448053 RHIVRKRtLRRLLQE X 14343 +PRKCD PKCD Q05655 human HuR 1994 Q15717 ELAVL1 human S318 2246702 GDkILQVsFkTNkSH X X +PRKCD PKCD Q05655 human TIF1B 21849 Q62318 Trim28 mouse S473 452391 SGMkRsRsGEGEVSG X +PRKCD PKCD Q05655 human S6 6194 P62753 RPS6 human S236 448093 AKRRRLssLRAstsK X 5006; 4856; 4857; 4858; 4851; 4803; 2211; 3945; 3985; 5316; 4854; 8520; 48319; 40643; 9865; 38573; 14733; 27036; 34411; 62016; 62788; 81736; 97935; 99457; 15448 +PRKCD PKCD Q05655 human NRF2 4780 Q16236 NFE2L2 human S40 450082 SREVFDFsQRRkEYE X +PRKCD PKCD Q05655 human HAX1 10456 O00165 HAX1 human S210 37043700 QPkSYFksIsVtkIT X X +PRKCD PKCD Q05655 human RPS3 6188 P23396 RPS3 human T221 452652 kDEILPttPIsEQkG X X +PRKCD PKCD Q05655 human CTNNB1 1499 P35222 CTNNB1 human S715 25288326 GYRQDDPsyRsFHsG X X +PRKCD PKCD Q05655 human PRKD1 5587 Q15139 PRKD1 human S412 20615903 PLMRVVQsVKHTKRK X X +PRKCD PKCD Q05655 human IRS1 3667 P35568 IRS1 human S307 450190 TRRsRtEsItAtsPA X 2384; 2491 +PRKCD PKCD Q05655 human TNNT2 286816 P13789 TNNT2 cow S195 451755 KAQtERKsGKRQtER Troponin X +PRKCD PKCD Q05655 human GSK3A 2931 P49840 GSK3A human S21 448584 sGrARtssFAEPGGG X 9337; 9316; 9331; 5090; 9327; 8452; 8566 +PRKCD PKCD Q05655 human CXCR4 7852 P61073 CXCR4 human S324 6140803 LtsVsRGssLkILsk X 85578 +PRKCD PKCD Q05655 human HVCN1 iso4 84329 Q96D96-4 HVCN1 human T9 472529 SKFLRHFtVVGDDYH X +PRKCD PKCD Q05655 human TNNI3 7137 P19429 TNNI3 human S24 448424 APIRRRssNyRAyAt Troponin-I_N X 4004 +PRKCD PKCD Q05655 human PPP1R14B 26472 Q96C90 PPP1R14B human T57 1904503 VRRQGKVtVkYDRKE PP1_inhibitor X +PRKCD PKCD Q05655 human TSC2 7249 P49815 TSC2 human S939 448501 sFRARstsLNERPKs X X 3615 +PRKCD PKCD Q05655 human FCER1G 2207 P30273 FCER1G human S69 13310016 DGVytGLstRNQEty ITAM X +PRKCD PKCD Q05655 human TRPC6 22068 Q61143 Trpc6 mouse S448 15794302 KFVAHAAsFTIFLGL Ion_trans; TM X +PRKCD PKCD Q05655 human TBL1XR1 79718 Q9BZK7 TBL1XR1 human S123 2509601 AAAsQQGsAKNGENT X +PRKCD PKCD Q05655 human GSK3B 2932 P49841 GSK3B human S9 449111 SGRPRttsFAEsCkP X 9336; 9331; 9327; 9323; 9322; 9325; 5558; 8566; 79774; 8466; 25462; 14026; 14332; 14310; 14630 +PRKCD PKCD Q05655 human STAT3 6774 P40763 STAT3 human S727 448191 NtIDLPMsPrTLDSL X X 9134; 9136; 34911; 94994; 49081; 58978; 87544; 71958; 50804 +PRKCD PKCD Q05655 human AID 11628 Q9WVE0 Aicda mouse S3 20660600 _____MDsLLMKQKK X +PRKCD PKCD Q05655 human CXCR4 7852 P61073 CXCR4 human S325 3849622 tsVsRGssLkILskG X 85578 +PRKCD PKCD Q05655 human DRP1 10059 O00429 DNM1L human S616 454690 PIPIMPAsPQKGHAV X 3455; 4494; 63940 +PRKCD PKCD Q05655 human CACNA1C 100101555 P15381 CACB rabbit S533 453091 RIsKSKFsRYWRRWN X +PRKCD PKCD Q05655 human TRPV4 59341 Q9HBA0 TRPV4 human S189 10272404 DEEFREPsTGKTCLP X +PRKCD PKCD Q05655 human p300 2033 Q09472 EP300 human S89 447592 SELLRSGsSPNLNMG X X +PRKCD PKCD Q05655 human TSC2 7249 P49815 TSC2 human S932 4728973 DDtPEkDsFRARsts X X +PRKCD PKCD Q05655 human lamin A/C 4000 P02545 LMNA human S22 452604 QAsstPLsPtRItRL X 2026; 13448 +PRKCD PKCD Q05655 human FLI1 2313 Q01543 FLI1 human T312 6406002 TNGEFKMtDPDEVAR Ets X X +PRKCD PKCD Q05655 human Met 4233 P08581 MET human S985 450188 PHLDRLVsARsVsPt X +PRKCD PKCD Q05655 human TNNI3 511094 P08057 TNNI3 cow S46 450691 KKSKIsAsRKLQLKT X +PRKCD PKCD Q05655 human HuR 1994 Q15717 ELAVL1 human S221 478357 QAQrFrFsPMGVDHM X X +PRKCD PKCD Q05655 human IRS1 3667 P35568 IRS1 human S441 1990800 SPCDFRSsFRsVtPD X +PRKCD PKCD Q05655 human TACSTD2 4070 P09758 TACSTD2 human S322 470219 GELRkEPsL______ X +PRKCD PKCD Q05655 human ANKRD54 223690 Q91WK7 Ankrd54 mouse S18 239773903 ESRsGRsssDGECAV X +PRKCD PKCD Q05655 human BVR 644 P53004 BLVRA human S33 25526803 DLRNPHPsSAFLNLI GFO_IDH_MocA X X +PRKCD PKCD Q05655 human Ebp1 5036 Q9UQ80 PA2G4 human S360 478276 ELkALLQssAsRKtQ X X +PRKCD PKCD Q05655 human HVCN1 84329 Q96D96 HVCN1 human T29 472529 SKFLRHFtVVGDDyH X +PRKCD PKCD Q05655 human Catalase 847 P04040 CAT human S167 30259808 LFPSFIHsQKRNPQT Catalase X +PRKCD PKCD Q05655 human p73 iso2 7161 O15350-2 TP73 human S289 455781 GQVLGRRsFEGRICA P53 X X +PRKCD PKCD Q05655 human PPAR-alpha 25747 P37230 Ppara rat S179 457549 RFGRMPRsEKAKLKA X +PRKCD PKCD Q05655 human Src 6714 P12931 SRC human S12 448230 KSKPKDAsQRRRsLE X +PRKCD PKCD Q05655 human G6PD iso3 2539 P11413-3 G6PD human T266 15207800 NIACVILtFKEPFGT G6PD_C X X +PRKCD PKCD Q05655 human ARHGAP3 1124 P52757 CHN2 human S171 13790300 EKVsRRLsRsKNEPR X X +PRKCD PKCD Q05655 human RKIP 5037 P30086 PEBP1 human S153 448755 RGKFkVAsFRKKYEL PBP X +PRKCD PKCD Q05655 human SHOC2 8036 Q9UQ13 SHOC2 human S297 31905007 GLRYNRLsAIPRSLA LRR_8 X +PRKCD PKCD Q05655 human p47phox 653361 P14598 NCF1 human S315 451725 AHsIHQRsRKRLsQD NECFESHC X +PRKCD PKCD Q05655 human BVR 644 P53004 BLVRA human S21 25526801 VGVGRAGsVRMRDLR GFO_IDH_MocA X X +PRKCD PKCD Q05655 human TNNI3 511094 P08057 TNNI3 cow S25 448424 PPVRRRssANYRAYA Troponin-I_N X +PRKCD PKCD Q05655 human p47phox 653361 P14598 NCF1 human S379 451498 DLILNRCsEstKRKL p47_phox_C X X +PRKCD PKCD Q05655 human RASGRP3 25780 Q8IV61 RASGRP3 human T133 454419 YDWMRRVtQRKKVSK X +PRKCD PKCD Q05655 human HVCN1 84329 Q96D96 HVCN1 human S97 12064203 GMLRKLFsSHRFQVI X +PIM2 Pim2 Q9P1W9 human EIF4B 300253 Q5RKG9 Eif4b rat S406 470374 RPRERHPsWRsEETQ X 8151; 5399 +PIM2 Pim2 Q9P1W9 human PKM 5315 P14618 PKM human T454 23132420 RAPIIAVtRNPQtAR PK_C X X +PIM2 Pim2 Q9P1W9 human FOXP3 20371 Q99JB6 Foxp3 mouse S41 41122600 ELLGTRGsGGPFQGR X X +PIM2 Pim2 Q9P1W9 human STAT5B 6777 P51692 STAT5B human S731 448751 TyMDQAPsPAVCPQA X +PIM2 Pim2 Q9P1W9 human HK2 3099 P52789 HK2 human T473 28704601 QHRARQktLEHLQLS Hexokinase_1 X X +PIM2 Pim2 Q9P1W9 human Myc 4609 P01106 MYC human S308 10852562 GHskPPHsPLVLkrC Myc_N X +PIM2 Pim2 Q9P1W9 human BAD 12015 Q61337 Bad mouse S155 447863 GRELRRMsDEFEGsF Bcl-2_BAD X 9297 +PIM2 Pim2 Q9P1W9 human PFKFB3 5209 Q16875 PFKFB3 human S478 9318263 tKKPRINsFEEHVAS X X +PIM2 Pim2 Q9P1W9 human p21Cip1 1026 P38936 CDKN1A human T145 447837 QGRkRRQtsMTDFyH X X +PIM2 Pim2 Q9P1W9 human LDH-A 3939 P00338 LDHA human S319 24986816 EEARLkksADtLWGI Ldh_1_C X +PIM2 Pim2 Q9P1W9 human BAD 12015 Q61337 Bad mouse S136 447862 PFRGRsRsAPPNLWA Bcl-2_BAD X 9295; 5286; 4366 +PIM2 Pim2 Q9P1W9 human LDH-A 3939 P00338 LDHA human S161 31882218 PkNrVIGsGCNLDsA X X +PIM2 Pim2 Q9P1W9 human Myc 17869 P01108 Myc mouse S344 2750300 AkRAKLDsGRVLKQI Myc_N X X +PIM2 Pim2 Q9P1W9 human FBPase 14121 Q9QXD6 Fbp1 mouse S144 15501075 FGIyRKKstDEPSEk FBPase X X +PIM2 Pim2 Q9P1W9 human HSF1 3297 Q00613 HSF1 human T120 54414377 ENIkRkVtsVSTLks X X +PIM2 Pim2 Q9P1W9 human BAD 12015 Q61337 Bad mouse S112 447860 ETRsRHssyPAGtEE Bcl-2_BAD X X 9291; 5284; 9296; 5193; 11865; 94223 +PIM2 Pim2 Q9P1W9 human AMPKA1 5562 Q13131 PRKAA1 human S467 7445995 LQLyQVDsRTYLLDF AdenylateSensor X X +PIM2 Pim2 Q9P1W9 human Notch 1 18128 Q01705 Notch1 mouse S2152 3252805 GkkARkPsTkGLACG X +PIM2 Pim2 Q9P1W9 human p21Cip1 1026 P38936 CDKN1A human S146 447836 GRkRRQtsMTDFyHs X +PIM2 Pim2 Q9P1W9 human PSMD2 5708 Q13200 PSMD2 human S361 487471 ENNrFGGsGsQVDsA X X +PIM2 Pim2 Q9P1W9 human IRS1 3667 P35568 IRS1 human S1101 453434 GCRRRHssEtFsStP X +PIM2 Pim2 Q9P1W9 human FOXP3 20371 Q99JB6 Foxp3 mouse S33 25292790 WkTAPkGsELLGTRG X X +PIM2 Pim2 Q9P1W9 human PFKFB3 170768 Q9ESY2 Pfkfb3 mouse S478 9318263 TKKPRINsFEERVAs X X +PIM2 Pim2 Q9P1W9 human FBPase 2203 P09467 FBP1 human S144 15501075 FGIYRKKsTDEPSEK FBPase X X +PIM2 Pim2 Q9P1W9 human PFKFB4 5210 Q16877 PFKFB4 human T140 1879811800 TTRERRAtIFNFGEQ X X +CAMK2A CAMK2A Q9UQM7 human SYN1 24949 P09951 Syn1 rat S566 456356 PQAtRQAsIsGPAPP X +CAMK2A CAMK2A Q9UQM7 human SynGAP 240057 F6SEU4 Syngap1 mouse S1135 451016 PSItKQHsQtPstLN DUF3498 X +CAMK2A CAMK2A Q9UQM7 human PLB 414755 P61012 PLN dog T17 448115 SAIRRAstIEMPQQA Phospholamban X 8496 +CAMK2A CAMK2A Q9UQM7 human AKAP5 9495 P24588 AKAP5 human S92 31878521 LVtRRKRsESsKQQK WSK X +CAMK2A CAMK2A Q9UQM7 human FAM134B 54463 Q9H6L5 RETREG1 human S151 2509195 AQLWRSLsESWEVIN Reticulon X +CAMK2A CAMK2A Q9UQM7 human SCN5A 6331 Q14524 SCN5A human T455 4719534 LTIRGVDtVsRssLE X +CAMK2A CAMK2A Q9UQM7 human Kv4.2 Q63881 Kcnd2 rat S459 2906104 LLSNQLQsSEDEPAF X X +CAMK2A CAMK2A Q9UQM7 human H1R 3269 P35367 HRH1 human T142 453405 YLKYRtKtRASATIL 7tm_1 X +CAMK2A CAMK2A Q9UQM7 human Vimentin 280955 P48616 VIM cow S26 451767 GTASRPSsTRSYVTT Filament_head X +CAMK2A CAMK2A Q9UQM7 human GJA1 24392 P08050 Gja1 rat S306 465459 RNYNkQAsEQNWANy Connexin43 X +CAMK2A CAMK2A Q9UQM7 human SCN5A 6331 Q14524 SCN5A human S484 3799157 KRRKRMssGtEECGE X +CAMK2A CAMK2A Q9UQM7 human CREB3L3 84699 Q68CJ9 CREB3L3 human S395 1880714004 ADTTREEsPGSPGAD X +CAMK2A CAMK2A Q9UQM7 human Ets-2 2114 P15036 ETS2 human S310 477898 LDVQRVPsFEsFEDD Ets1_N_flank X X +CAMK2A CAMK2A Q9UQM7 human ITPKA 3706 P23677 ITPKA human T311 451074 EHAQRAVtKPRYMQW IPK X X +CAMK2A CAMK2A Q9UQM7 human SCN5A 6331 Q14524 SCN5A human S457 4719540 IRGVDtVsRssLEMs X +CAMK2A CAMK2A Q9UQM7 human SMRT 9612 Q9Y618 NCOR2 human S2426 6422852 AsGDRPPsVSSVHsE X X +CAMK2A CAMK2A Q9UQM7 human CAMK2A 25400 P11275 Camk2a rat T310 2869607 ILttMLAtRNFsGGK X +CAMK2A CAMK2A Q9UQM7 human Kir6.2 3767 Q14654 KCNJ11 human T180 450652 QAHRRAEtLIFSKHA X X +CAMK2A CAMK2A Q9UQM7 human GJC1 14615 P28229 Gjc1 mouse S381 22598808 SKSGSNKssIssKsG X +CAMK2A CAMK2A Q9UQM7 human NOX5 iso4 79400 Q96PH1-4 NOX5 human S498 472626 RSVtMRKsQRSsKGS FAD_binding_8 X +CAMK2A CAMK2A Q9UQM7 human SCN8A 6334 Q9UQD0 SCN8A human T642 1869659201 RSVKRNstVDCNGVV Na_trans_cytopl X X +CAMK2A CAMK2A Q9UQM7 human PSD-95 29495 P31016 Dlg4 rat S73 471390 ITLERGNsGLGFSIA PDZ X X +CAMK2A CAMK2A Q9UQM7 human ITGB1 3688 P05556 ITGB1 human T788 448600 PIyksAVttVVNPky Integrin_b_cyt X +CAMK2A CAMK2A Q9UQM7 human TH iso4 7054 P07101-4 TH human S35 448544 AIMVRGQsPRFIGRR TOH_N X +CAMK2A CAMK2A Q9UQM7 human GJA1 24392 P08050 Gja1 rat S372 465460 sRAssRAssRPRPDD X +CAMK2A CAMK2A Q9UQM7 human SPR 29270 P18297 Spr rat S46 469984 LLSARSDsMLRQLKE adh_short X +CAMK2A CAMK2A Q9UQM7 human SCN5A 6331 Q14524 SCN5A human S12 40413902 LLPRGTssFRRFtRE X +CAMK2A CAMK2A Q9UQM7 human Caldesmon 373965 P12957 CALD1 chicken T484 457423 QNGERELtTPKLKsT Caldesmon X +CAMK2A CAMK2A Q9UQM7 human Ets-2 2114 P15036 ETS2 human S313 7113800 QRVPsFEsFEDDCsQ Ets1_N_flank X X +CAMK2A CAMK2A Q9UQM7 human SCN5A 6331 Q14524 SCN5A human S61 40413904 PQLDLQAsKKLPDLY X +CAMK2A CAMK2A Q9UQM7 human DAT 24898 P23977 Slc6a3 rat S13 451138 CsVGPMssVVAPAKE X +CAMK2A CAMK2A Q9UQM7 human Telethonin 8557 O15273 TCAP human S157 448693 GALRRsLsRSMsQEA Telethonin X +CAMK2A CAMK2A Q9UQM7 human sarcolipin 6588 O00631 SLN human T5 459214 ___MGINtRELFLNF Sarcolipin X +CAMK2A CAMK2A Q9UQM7 human CAMK2A 815 Q9UQM7 CAMK2A human T286 447797 sCMHRQEtVDCLKKF X X 12716 +CAMK2A CAMK2A Q9UQM7 human HSL 25330 P15304 Lipe rat S865 448804 ESMRRsVsEAALAQP X 4137 +CAMK2A CAMK2A Q9UQM7 human SCN5A 6331 Q14524 SCN5A human S464 40413909 sRssLEMsPLAPVNs X +CAMK2A CAMK2A Q9UQM7 human CHAT iso3 1103 P28329-3 CHAT human T456 449058 VDNIRSAtPEALAFV Carn_acyltransf X +CAMK2A CAMK2A Q9UQM7 human CAMK2A 815 Q9UQM7 CAMK2A human T305 448802 kLkGAILttMLAtRN X +CAMK2A CAMK2A Q9UQM7 human FosB 14282 P13346 Fosb mouse T149 35530404 PRRPREEtLTPEEEE X +CAMK2A CAMK2A Q9UQM7 human CPEB3 208922 Q7TN99 Cpeb3 mouse S298 25734909 sPLKKPFssNVIAPP X +CAMK2A CAMK2A Q9UQM7 human Ets-1 2113 P14921 ETS1 human S285 449318 QRVPsyDsFDsEDyP Ets1_N_flank X X +CAMK2A CAMK2A Q9UQM7 human SynGAP 240057 F6SEU4 Syngap1 mouse S1162 4792809 VSNMPHLsADIESAH DUF3498 X +CAMK2A CAMK2A Q9UQM7 human SCN5A 6331 Q14524 SCN5A human S571 27281507 PWPLRRtsAQGQPsP Na_trans_cytopl X X +CAMK2A CAMK2A Q9UQM7 human SPR 6697 P35270 SPR human S213 469983 QQLARETsVDPDMRK adh_short X +CAMK2A CAMK2A Q9UQM7 human SCN8A 6334 Q9UQD0 SCN8A human S541 23142148 NRIGRKFsIMNQsLL X +CAMK2A CAMK2A Q9UQM7 human CREB3L3 84699 Q68CJ9 CREB3L3 human S360 1880714000 FAPVRVFsRTLHNDA X +CAMK2A CAMK2A Q9UQM7 human MOR-1 25601 P33535 Oprm1 rat S266 447782 LKsVRMLsGSKEKDR 7tm_1 X +CAMK2A CAMK2A Q9UQM7 human SLC1A3 6507 P43003 SLC1A3 human T26 54247427 QQGVRKRtLLAKkkV X +CAMK2A CAMK2A Q9UQM7 human Securin 9232 O95997 PTTG1 human S31 30977068 LkLGsGPsIkALDGR Securin X +CAMK2A CAMK2A Q9UQM7 human SMAD2 4087 Q15796 SMAD2 human S260 450146 TLsPVNHsLDLQPVT X X +CAMK2A CAMK2A Q9UQM7 human PPP3CA 24674 P63329 Ppp3ca rat S411 2048309 GKMARVFsVLREESE X +CAMK2A CAMK2A Q9UQM7 human TRPC6 22068 Q61143 Trpc6 mouse T487 27839400 RQLFRMKtSCFSWME Ion_trans; TM X +CAMK2A CAMK2A Q9UQM7 human CACNA1C 100101555 P15381 CACB rabbit S1575 467228 VACKRLVsMNMPLNS GPHH X +CAMK2A CAMK2A Q9UQM7 human RYR2 F1PEE8 RYR2 dog S2016 455603 TIRGRLLsLVEKVTY X +CAMK2A CAMK2A Q9UQM7 human TH iso4 7054 P07101-4 TH human S19 448542 KGFRRAVsELDAKQA TOH_N X +CAMK2A CAMK2A Q9UQM7 human p27Kip1 1027 P46527 CDKN1B human S10 447874 NVRVSNGsPsLErMD X +CAMK2A CAMK2A Q9UQM7 human SRF 6722 P11831 SRF human S103 447692 RGLKRsLsEMEIGMV X 4261 +CAMK2A CAMK2A Q9UQM7 human CYLD 1540 Q9NQC7 CYLD human S362 31957307 FyTLNGSsVDSQPQs CYLD_phos_site X X +CAMK2A CAMK2A Q9UQM7 human Caldesmon 373965 P12957 CALD1 chicken S602 457430 CFsPKGSsLKIEERA Caldesmon X +CAMK2A CAMK2A Q9UQM7 human GJA1 24392 P08050 Gja1 rat S325 449992 NRMGQAGstIsNsHA Connexin43 X +CAMK2A CAMK2A Q9UQM7 human ANO1 101772 Q8BHY3 Ano1 mouse S471 50773175 EKSLRKEsRNKETDK Anoctamin X +CAMK2A CAMK2A Q9UQM7 human GJC1 14615 P28229 Gjc1 mouse S384 22598805 GSNKssIssKsGDGK X +CAMK2A CAMK2A Q9UQM7 human TRPV1 83810 O35433 Trpv1 rat S502 450016 YFLQRRPsLKSLFVD Ion_trans X +CAMK2A CAMK2A Q9UQM7 human AKAP5 9495 P24588 AKAP5 human T87 406855301 AsLKRLVtRRKRsES WSK X +CAMK2A CAMK2A Q9UQM7 human RYR2 6262 Q92736 RYR2 human S2814 458801 IsQTSQVsVDAAHGY X +CAMK2A CAMK2A Q9UQM7 human Abi-1 11308 Q8CBW3 Abi1 mouse S88 27115701 SQLRRMEsSINHISQ X +CAMK2A CAMK2A Q9UQM7 human SCN5A 6331 Q14524 SCN5A human S528 451569 KPRssrGsIFtFRRR Na_trans_cytopl X +CAMK2A CAMK2A Q9UQM7 human MCU 215999 Q3UMR5 Mcu mouse S56 27259016 TAHQRPAsWQSVGAA X +CAMK2A CAMK2A Q9UQM7 human GluR1 50592 P19490 Gria1 rat S849 448565 FCLIPQQsINEAIrT X X 75574 +CAMK2A CAMK2A Q9UQM7 human HDAC5 10014 Q9UQL6 HDAC5 human S498 447996 RPLSRtQsSPLPQsP X 3424 +CAMK2A CAMK2A Q9UQM7 human Vimentin 7431 P08670 VIM human S83 451816 GVRLLQDsVdFsLAd Filament_head X 3878; 12569 +CAMK2A CAMK2A Q9UQM7 human PTPRA 19262 P18052 Ptpra mouse S180 447611 QAGsHSNsFRLSNGR X +CAMK2A CAMK2A Q9UQM7 human ICAP1 9270 O14713 ITGB1BP1 human T38 450887 GGLsRsstVAsLDTD ICAP-1_inte_bdg X +CAMK2A CAMK2A Q9UQM7 human eNOS 18127 P70313 Nos3 mouse S1176 447884 TSRIRtQsFsLQERQ X 9571; 9570 +CAMK2A CAMK2A Q9UQM7 human SMARCA2 67155 Q6DIC0 Smarca2 mouse S1382 470425 RPPAEKLsPNPPKLT X +CAMK2A CAMK2A Q9UQM7 human GluR1 14799 P23818 Gria1 mouse S849 448565 FCLIPQQsINEAIRt X X 75574 +CAMK2A CAMK2A Q9UQM7 human SCN5A 6331 Q14524 SCN5A human S497 23142130 GEDRLPKsDsEDGPR X +CAMK2A CAMK2A Q9UQM7 human NOX5 iso4 79400 Q96PH1-4 NOX5 human S475 20612400 WTNRLYEsFKASDPL FAD_binding_8 X X +CAMK2A CAMK2A Q9UQM7 human SERT 6532 P31645 SLC6A4 human S13 31014803 LNSQKQLsACEDGED X +CAMK2A CAMK2A Q9UQM7 human TH 7054 P07101 TH human S71 448545 RFIGRRQsLIEDARK TOH_N X 2791 +CAMK2A CAMK2A Q9UQM7 human sarcolipin Q6SLE7 Sln rat T5 459214 ___MERStQELFINF Sarcolipin X +CAMK2A CAMK2A Q9UQM7 human NLGN1 192167 Q99K10 Nlgn1 mouse T739 30318201 CSPQRTTtNDLTHAP X X +CAMK2A CAMK2A Q9UQM7 human CRMP-2 12934 O08553 Dpysl2 mouse T555 448084 DNIPRRttQRIVAPP X X +CAMK2A CAMK2A Q9UQM7 human SMAD2 4087 Q15796 SMAD2 human S110 450144 SFSEQTRsLDGRLQV MH1 X X +CAMK2A CAMK2A Q9UQM7 human CREB iso1 81646 P15337-1 Creb1 rat S133 448228 EILsRRPsYRkILND pKID X X 9187; 9196; 9198; 4095; 14228; 14001; 39561; 80120; 44864; 54960; 95995 +CAMK2A CAMK2A Q9UQM7 human GJC1 14615 P28229 Gjc1 mouse S326 15499912 AQEQQYGsHEEHLPA X +CAMK2A CAMK2A Q9UQM7 human PXR 8856 O75469 NR1I2 human T290 25682902 LCQLRFNtVFNAETG Hormone_recep X X +CAMK2A CAMK2A Q9UQM7 human FLNA 2316 P21333 FLNA human S2523 448843 VTGPRLVsNHsLHET X +CAMK2A CAMK2A Q9UQM7 human beclin 1 8678 Q14457 BECN1 human S96 472002 MstEsANsFTLIGEA X +CAMK2A CAMK2A Q9UQM7 human RYR2 689560 B0LPN4 Ryr2 rat S2804 458801 IsQTsQVsIDAAHGY X +CAMK2A CAMK2A Q9UQM7 human PPP1R14A 94274 Q96A00 PPP1R14A human S130 454707 GLRQPsPsHDGsLsP PP1_inhibitor X +CAMK2A CAMK2A Q9UQM7 human Kv7.2 iso4 3785 O43526-4 KCNQ2 human S438 481666 QTVRRsPsADQSLED KCNQ_channel X +CAMK2A CAMK2A Q9UQM7 human Ets-1 2113 P14921 ETS1 human S282 449317 NsLQRVPsyDsFDsE Ets1_N_flank X X +CAMK2A CAMK2A Q9UQM7 human NMDAR2B 24410 Q00960 Grin2b rat S1303 450171 NKLRRQHsyDtFVDL NMDAR2_C X 20274; 71335 +CAMK2A CAMK2A Q9UQM7 human GJA1 24392 P08050 Gja1 rat S255 448852 HATTGPLsPskDCGs X +CAMK2A CAMK2A Q9UQM7 human SCN5A 6331 Q14524 SCN5A human S1925 4719576 QRsLKHAsFLFRQQA X +CAMK2A CAMK2A Q9UQM7 human RYR2 20191 E9Q401 Ryr2 mouse S2813 458801 IsQtsQVsIDAAHGY X +CAMK2A CAMK2A Q9UQM7 human SCN5A 6331 Q14524 SCN5A human S510 27281506 PRAMNHLsLTrGLsR Na_trans_cytopl X +CAMK2A CAMK2A Q9UQM7 human Vimentin 81818 P31000 Vim rat S39 451766 TTSTRTYsLGSALRP Filament_head X 13614 +CAMK2A CAMK2A Q9UQM7 human CPEB3 208922 Q7TN99 Cpeb3 mouse T446 4743577 ssGLssPtRCQNGER X +CAMK2A CAMK2A Q9UQM7 human gephyrin 64845 Q03555 Gphn rat S337 481401 NILRAsHsAVDITKV X +CAMK2A CAMK2A Q9UQM7 human CACNA1B 257648 Q02294 Cacna1b rat S2126 467286 SEKQRFYsCDRFGsR X +CAMK2A CAMK2A Q9UQM7 human GFAT 2673 Q06210 GFPT1 human S261 467935 CNLsRVDsttCLFPV X +CAMK2A CAMK2A Q9UQM7 human SCN5A 6331 Q14524 SCN5A human S11 40413901 FLLPRGTssFRRFtR X +CAMK2A CAMK2A Q9UQM7 human SCN5A 6331 Q14524 SCN5A human S577 40413905 tsAQGQPsPGTSAPG Na_trans_cytopl X +CAMK2A CAMK2A Q9UQM7 human CTNNB1 1499 P35222 CTNNB1 human S552 472273 QDtQRRtsMGGtQQQ X 9566; 5651 +CAMK2A CAMK2A Q9UQM7 human CAMK2A 12322 P11798 Camk2a mouse T286 447797 sCMHRQEtVDCLkkF X X 12716 +CAMK2A CAMK2A Q9UQM7 human SAPAP1 iso2 9229 O14490-2 DLGAP1 human S44 456939 CRRMRSGsYIKAMGD X 13638 +CAMK2A CAMK2A Q9UQM7 human nNOS 24598 P29476 Nos1 rat S847 447886 SYKVRFNsVSSYSDS Flavodoxin_1 X +CAMK2A CAMK2A Q9UQM7 human CAMK2A 25400 P11275 Camk2a rat T305 448802 kLkGAILttMLAtRN X +CAMK2A CAMK2A Q9UQM7 human GJA1 24392 P08050 Gja1 rat S365 459207 IVDQRPssRAssRAs X +CAMK2A CAMK2A Q9UQM7 human CAMK2A 25400 P11275 Camk2a rat T306 449596 LkGAILttMLAtRNF X +CAMK2A CAMK2A Q9UQM7 human SCN5A 20271 Q9JJV9 Scn5a mouse S571 27281507 PWPLRRPsTQGQPGF Na_trans_cytopl X +CAMK2A CAMK2A Q9UQM7 human CREB3L3 84699 Q68CJ9 CREB3L3 human T429 1880714002 TLVLRNAtEGLGQVA X +CAMK2A CAMK2A Q9UQM7 human SCN5A 6331 Q14524 SCN5A human S1934 40413914 LFRQQAGsGLsEEDA X +CAMK2A CAMK2A Q9UQM7 human SCN5A 6331 Q14524 SCN5A human S539 4719564 FRRRDLGsEADFADD Na_trans_cytopl X +CAMK2A CAMK2A Q9UQM7 human SYN1 281510 P17599 SYN1 cow S605 450236 AGPTRQAsQAGPMPR X +CAMK2A CAMK2A Q9UQM7 human DRD3 29238 P19020 Drd3 rat S229 482885 RILTRQNsQCISIRP 7tm_1 X +CAMK2A CAMK2A Q9UQM7 human ITGB1 3688 P05556 ITGB1 human T789 447709 IyksAVttVVNPkyE Integrin_b_cyt X +CAMK2A CAMK2A Q9UQM7 human 5-LO 240 P09917 ALOX5 human S272 450169 CsLERQLsLEQEVQQ Lipoxygenase X 3748 +CAMK2A CAMK2A Q9UQM7 human GJA1 24392 P08050 Gja1 rat S364 450183 AIVDQRPssRAssRA X +CAMK2A CAMK2A Q9UQM7 human SCN5A 6331 Q14524 SCN5A human S516 4719558 LsLTrGLsRTsMKPR Na_trans_cytopl X X +CAMK2A CAMK2A Q9UQM7 human GJA1 24392 P08050 Gja1 rat S314 486031 EQNWANysAEQNRMG Connexin43 X +CAMK2A CAMK2A Q9UQM7 human ID1 3397 P41134 ID1 human S36 15411040 GEVVRCLsEQSVAIS X +CAMK2A CAMK2A Q9UQM7 human GABBR1 54393 Q9WV18 Gabbr1 mouse S867 15167000 ITRGEWQsEAQDtMK X +CAMK2A CAMK2A Q9UQM7 human GJA1 24392 P08050 Gja1 rat S328 449993 GQAGstIsNsHAQPF Connexin43 X +CAMK2A CAMK2A Q9UQM7 human SCN5A 6331 Q14524 SCN5A human S460 4719552 VDtVsRssLEMsPLA X +CAMK2A CAMK2A Q9UQM7 human P2X3 81739 P49654 P2rx3 rat T388 33402211 ATVEKQStDSGAySI X +CAMK2A CAMK2A Q9UQM7 human MOR-1 25601 P33535 Oprm1 rat S261 447781 LMILRLKsVRMLsGS 7tm_1 X +CAMK2A CAMK2A Q9UQM7 human H1R 3269 P35367 HRH1 human S398 450937 WKRLRsHsRQyVSGL 7tm_1 X +CAMK2A CAMK2A Q9UQM7 human SynGAP 240057 F6SEU4 Syngap1 mouse S766 4792737 MMRDLNssIDLQSFM DUF3498 X +CAMK2A CAMK2A Q9UQM7 human Ets-1 2113 P14921 ETS1 human S257 449319 DsFEsIEsyDsCDRL Ets1_N_flank X X +CAMK2A CAMK2A Q9UQM7 human Vimentin 280955 P48616 VIM cow S412 451764 EGEESRIsLPLPNFS X +CAMK2A CAMK2A Q9UQM7 human CLCN3 1182 P51790 CLCN3 human S109 451427 ERHRRINsKKKESAW X X +CAMK2A CAMK2A Q9UQM7 human CTNNB1 1499 P35222 CTNNB1 human T332 29614600 VNIMRTytyEkLLWT X +CAMK2A CAMK2A Q9UQM7 human SCN8A 6334 Q9UQD0 SCN8A human S561 1869659200 PFLSRHNsKSSIFSF Na_trans_cytopl X +CAMK2A CAMK2A Q9UQM7 human Vimentin 280955 P48616 VIM cow S66 451765 GVYATRSsAVRLRsG Filament_head X +CAMK2A CAMK2A Q9UQM7 human gp130 3572 P40189 IL6ST human S782 448180 QVFSRsEsTQPLLDS X +CAMK2A CAMK2A Q9UQM7 human HSF1 3297 Q00613 HSF1 human S230 448072 PkYSRQFsLEHVHGS X +CAMK2A CAMK2A Q9UQM7 human HOMER2 26557 Q9QWW1 Homer2 mouse S117 3893303 ARLARDKsQEKTEtS X +CAMK2A CAMK2A Q9UQM7 human Caldesmon 373965 P12957 CALD1 chicken S741 457434 RNLWEKQsVEKPAAS X +CAMK2A CAMK2A Q9UQM7 human NFL 281348 P02548 NEFL cow S58 457405 LSVRRsYsSSSGsLM Filament_head X +CAMK2A CAMK2A Q9UQM7 human CPEB3 208922 Q7TN99 Cpeb3 mouse S419 54003201 YGRRRGRssLFPFED X X +CAMK2A CAMK2A Q9UQM7 human GJA1 24392 P08050 Gja1 rat S330 449994 AGstIsNsHAQPFDF Connexin43 X +CAMK2A CAMK2A Q9UQM7 human myelin P0 539462 P10522 MPZ cow S233 458933 SRSTKAAsEKKTKGL Myelin-PO_C X +CAMK2A CAMK2A Q9UQM7 human PTPRA 19262 P18052 Ptpra mouse S204 447612 PLLARsPstNRKYPP X +CAMK2A CAMK2A Q9UQM7 human RIMS1 84556 Q9JIR4 Rims1 rat S287 455664 KQASRSRsEPPRERK X +CAMK2A CAMK2A Q9UQM7 human CACNA1C 12288 Q01815 Cacna1c mouse S1545 467228 VACKRLVsMNMPLNS GPHH X +CAMK2A CAMK2A Q9UQM7 human NFL 281348 P02548 NEFL cow S67 451023 SSGsLMPsLEsLDLS Filament_head X +CAMK2A CAMK2A Q9UQM7 human IP3R2 P29995 Itpr2 rat S150 26415703 EKNAMRVsLDAAGNE Ins145_P3_rec X +CAMK2A CAMK2A Q9UQM7 human HDAC5 10014 Q9UQL6 HDAC5 human S259 447995 FPLRkTAsEPNLKVR X 3443 +CAMK2A CAMK2A Q9UQM7 human CACNA1C 100101555 P15381 CACB rabbit S1700 4714250 PEIRRAIsGDLtAEE CAC1F_C X +CAMK2A CAMK2A Q9UQM7 human MCU 215999 Q3UMR5 Mcu mouse S91 27259017 VISVRLPsRRERCQF X +CAMK2A CAMK2A Q9UQM7 human CAMK2A iso2 815 Q9UQM7-2 CAMK2A human T286 447797 SCMHRQEtVDCLKKF X +CAMK2A CAMK2A Q9UQM7 human SynGAP 240057 F6SEU4 Syngap1 mouse S752 3573950 PMVLRGPsAEMQGyM DUF3498 X +CAMK2A CAMK2A Q9UQM7 human smMLCK 396445 P11799 MYLK chicken S1762 455821 GMsGRKAsGssPTsP X +CAMK2A CAMK2A Q9UQM7 human SMAD2 4087 Q15796 SMAD2 human S240 450145 SDQQLNQsMDTGsPA X X +CAMK2A CAMK2A Q9UQM7 human Vimentin 280955 P48616 VIM cow S72 449026 SsAVRLRsGVPGVRL Filament_head X +CAMK2A CAMK2A Q9UQM7 human TNNT2 286816 P13789 TNNT2 cow T191 449038 GYIQKAQtERKsGKR Troponin X +CAMK2A CAMK2A Q9UQM7 human MOR-1 25601 P33535 Oprm1 rat T370 447785 sTRVRQNtREHPsTA X +CAMK2A CAMK2A Q9UQM7 human CACNA1C BAA34185.2 CACNA1C guinea pig T1603 7437803 RTALRIKtEGNLEQA Ca_chan_IQ X +CAMK2A CAMK2A Q9UQM7 human SynGAP 240057 F6SEU4 Syngap1 mouse S1222 472605 EYERRLLsQEEQTSk DUF3498 X +CAMK2A CAMK2A Q9UQM7 human SynGAP 240057 F6SEU4 Syngap1 mouse S1111 481549 QsLskEGsIGGsGGs DUF3498 X +CAMK2A CAMK2A Q9UQM7 human SCN8A 6334 Q9UQD0 SCN8A human S641 1869659202 RRSVKRNstVDCNGV Na_trans_cytopl X +CAMK2A CAMK2A Q9UQM7 human SCN5A 6331 Q14524 SCN5A human S483 3799151 sKRRKRMssGtEECG X +CAMK2A CAMK2A Q9UQM7 human SynGAP 240057 F6SEU4 Syngap1 mouse S1107 1867842100 RPRQQsLskEGsIGG DUF3498 X +CAMK2A CAMK2A Q9UQM7 human MECP2 29386 Q00566 Mecp2 rat S421 470075 EKMPRAGsLESDGCP X +CAMK2A CAMK2A Q9UQM7 human KCND1 3750 Q9NSA2 KCND1 human S555 4714921 TASVSRGsMQELDML X +CAMK2A CAMK2A Q9UQM7 human FBX43 286151 Q4G163 FBXO43 human T234 13419500 FSQQKTStIDDSKDD X +CAMK2A CAMK2A Q9UQM7 human CAMK2A 815 Q9UQM7 CAMK2A human T306 449596 LkGAILttMLAtRNF X +CAMK2A CAMK2A Q9UQM7 human RRAD 6236 P55042 RRAD human S273 457396 AGTRRREsLGKKAKR X +CAMK2A CAMK2A Q9UQM7 human phosducin 20028 Q9QW08 Pdc mouse S54 454888 KEILRQMsSPQSRDD Phosducin X +CAMK2A CAMK2A Q9UQM7 human Caldesmon 373965 P12957 CALD1 chicken S59 1868253000 QKEEGDVsGEVTEKS Caldesmon X +CAMK2A CAMK2A Q9UQM7 human SYN1 20964 O88935 Syn1 mouse S605 450236 AGPtRQAsQAGPGPr X 88246 +CAMK2A CAMK2A Q9UQM7 human FosB 14282 P13346 Fosb mouse T180 35530403 RNRRRELtDRLQAET bZIP_1 X +CAMK2A CAMK2A Q9UQM7 human GJA1 24392 P08050 Gja1 rat S373 459209 RAssRAssRPRPDDL X +CAMK2A CAMK2A Q9UQM7 human RIMS1 84556 Q9JIR4 Rims1 rat S241 455663 RLQERSRsQTPLSTA X +CAMK2A CAMK2A Q9UQM7 human KIF3A 16568 P28741 Kif3a mouse S698 50247605 KPEtVIDsLLQ____ X +CAMK2A CAMK2A Q9UQM7 human KIF3A 16568 P28741 Kif3a mouse T694 31906433 KRsAKPEtVIDsLLQ X +CAMK2A CAMK2A Q9UQM7 human TH iso4 7054 P07101-4 TH human S44 448545 RFIGRRQsLIEDARK TOH_N X 2791 +CAMK2A CAMK2A Q9UQM7 human PANX1 315435 P60570 Panx1 rat S394 14577460 TKGEDQGsQRMDFKD X +CAMK2A CAMK2A Q9UQM7 human RCHY1 25898 Q96PM5 RCHY1 human T154 483981 ICLEDIHtsRVVAHV zf-RING_2 X X +CAMK2A CAMK2A Q9UQM7 human CACNA1C iso4 P15381-4 CACNA1C rabbit S1570 467228 VACKRLVsMNMPLNS GPHH X +CAMK2A CAMK2A Q9UQM7 human DLG1 25252 Q62696 Dlg1 rat S39 451614 SSIERVIsIFQSNLF L27_1 X +CAMK2A CAMK2A Q9UQM7 human CACNA1C iso4 P15381-4 CACNA1C rabbit S1512 460572 DYLTRDWsILGPHHL Ion_trans X +CAMK2A CAMK2A Q9UQM7 human CACNA1B 257648 Q02294 Cacna1b rat S784 455282 RLQNLRAsCEALYSE X +CAMK2A CAMK2A Q9UQM7 human STMN1 3925 P16949 STMN1 human S16 448554 kELEKrAsGQAFELI Stathmin X 3353 +CAMK2A CAMK2A Q9UQM7 human GJA1 24392 P08050 Gja1 rat S257 465456 TTGPLsPskDCGsPk X +CAMK2A CAMK2A Q9UQM7 human TPH2 216343 Q8CGV2 Tph2 mouse S19 470085 YWARRGLsLDSAVPE X +CAMK2A CAMK2A Q9UQM7 human GJC1 14615 P28229 Gjc1 mouse S382 22598807 KSGSNKssIssKsGD X +CAMK2A CAMK2A Q9UQM7 human mGluR1 24414 P23385 Grm1 rat T871 4713375 KLPCRSNtFLNIFRR X +CAMK2A CAMK2A Q9UQM7 human Securin 9232 O95997 PTTG1 human S89 31879178 KQKQPsFsAKKMTEK Securin X +CAMK2A CAMK2A Q9UQM7 human SCN5A 6331 Q14524 SCN5A human T17 40413900 TssFRRFtREsLAAI X +CAMK2A CAMK2A Q9UQM7 human CACNA1C 12288 Q01815 Cacna1c mouse S1487 460572 DYLTRDWsILGPHHL Ion_trans X +CAMK2A CAMK2A Q9UQM7 human HOMER2 26557 Q9QWW1 Homer2 mouse S216 51633301 EQWKRQFsICRDEND X +CAMK2A CAMK2A Q9UQM7 human TH 7054 P07101 TH human S19 448542 KGFRRAVsELDAKQA TOH_N X X +CAMK2A CAMK2A Q9UQM7 human SCN5A 6331 Q14524 SCN5A human S1920 40413910 RRHLLQRsLKHAsFL X +CAMK2A CAMK2A Q9UQM7 human SCN5A 6331 Q14524 SCN5A human S1885 40413913 KFMAANPsKISYEPI X +CAMK2A CAMK2A Q9UQM7 human NMDAR2A 2903 Q12879 GRIN2A human S1459 481117 RVYKKMPsIESDV__ NMDAR2_C X X +CAMK2A CAMK2A Q9UQM7 human CYLD 1540 Q9NQC7 CYLD human S418 4745557 TTENRFHsLPFsLtK CYLD_phos_site X X 4500 +CAMK2A CAMK2A Q9UQM7 human MYH9 25745 Q62812 Myh9 rat T1940 452194 RRIVRKGtGDCsDEE X +CAMK2A CAMK2A Q9UQM7 human SMRT 9612 Q9Y618 NCOR2 human S2453 4785906 VWEDRPssAGstPFP X +CAMK2A CAMK2A Q9UQM7 human MOR-1 4988 P35372 OPRM1 human S268 447782 LKsVRMLsGsKEKDR 7tm_1 X +CAMK2A CAMK2A Q9UQM7 human NOX5 iso4 79400 Q96PH1-4 NOX5 human S659 20612404 ANKEKKDsITGLQTR NAD_binding_6 X +CAMK2A CAMK2A Q9UQM7 human DLG1 25252 Q62696 Dlg1 rat S232 451615 ITLERGNsGLGFSIA PDZ X +CAMK2A CAMK2A Q9UQM7 human KIF3A 11127 Q9Y496 KIF3A human S687 454304 KTGRRKRsAkPEtVI X +CAMK2A CAMK2A Q9UQM7 human CPEB3 208922 Q7TN99 Cpeb3 mouse S420 54003200 GRRRGRssLFPFEDA X X +CAMK2A CAMK2A Q9UQM7 human Caldesmon 373965 P12957 CALD1 chicken S26 457417 RLEAERLsyQRNDDD X +CAMK2A CAMK2A Q9UQM7 human GluR2 14800 P23819 Gria2 mouse S880 448351 yNVyGIEsVKI____ X +CAMK2A CAMK2A Q9UQM7 human SCN5A 6331 Q14524 SCN5A human S667 25752820 QRALsAVsVLtsALE Na_trans_cytopl X +CAMK2A CAMK2A Q9UQM7 human PLB 18821 P61014 Pln mouse T17 448115 SAIRRAstIEMPQQA Phospholamban X 8496 +CAMK2A CAMK2A Q9UQM7 human NSDDR 747 Q9Y4D2 DAGLA human S782 27807805 APLATMEsLSDTESL X +CAMK2A CAMK2A Q9UQM7 human SCN5A 6331 Q14524 SCN5A human S20 40413903 FRRFtREsLAAIEKR X +CAMK2A CAMK2A Q9UQM7 human CARD11 84433 Q9BXL7 CARD11 human S116 466431 KEPTRRFstIVVEEG X +CAMK2A CAMK2A Q9UQM7 human KIF17 16559 Q99PW8 Kif17 mouse S1029 1720900 SKAKRKKsKNSFGGE X +CAMK2A CAMK2A Q9UQM7 human CAMK2A 25400 P11275 Camk2a rat S314 451708 MLAtRNFsGGKSGGN X +CAMK2A CAMK2A Q9UQM7 human RYR2 F1PEE8 RYR2 dog S2799 458801 IsQTSQVsVDAAHGY X +CAMK2A CAMK2A Q9UQM7 human NFL 281348 P02548 NEFL cow S70 466427 sLMPsLEsLDLSQVA Filament_head X +CAMK2A CAMK2A Q9UQM7 human SCN5A 6331 Q14524 SCN5A human S1937 40413906 QQAGsGLsEEDAPER X +CAMK2A CAMK2A Q9UQM7 human NMDAR2A 14811 P35436 Grin2a mouse S1459 481117 RVYKKMPsIEsDV__ NMDAR2_C X X +CAMK2A CAMK2A Q9UQM7 human SLC1A3 6507 P43003 SLC1A3 human T37 60189903 KkkVQNItkEDVKSY X +CAMK2A CAMK2A Q9UQM7 human SynGAP 240057 F6SEU4 Syngap1 mouse S1105 8098868 PARPRQQsLskEGsI DUF3498 X +CAMK2A CAMK2A Q9UQM7 human PLCB3 5331 Q01970 PLCB3 human S537 448450 PSLEPQKsLGDEGLN X X 2481; 29021 +CAMK2A CAMK2A Q9UQM7 human SynGAP 240057 F6SEU4 Syngap1 mouse S780 451015 MARGLNSsMDMARLP DUF3498 X +CAMK2A CAMK2A Q9UQM7 human CACNA1B 257648 Q02294 Cacna1b rat S896 455283 ERARPRRsHsKEAPG X +CAMK2A CAMK2A Q9UQM7 human PPP2R2B iso2 5521 Q00005-2 PPP2R2B human S22 25554902 PNTILsssCHTEADI X +CAMK2A CAMK2A Q9UQM7 human GJA1 24392 P08050 Gja1 rat S296 465457 VTGDRNNssCRNYNk Connexin43 X +CAMK2A CAMK2A Q9UQM7 human SPR 29270 P18297 Spr rat S214 469983 QQLARETsMDPELRS adh_short X +CAMK2A CAMK2A Q9UQM7 human RCHY1 25898 Q96PM5 RCHY1 human S155 483982 CLEDIHtsRVVAHVL zf-RING_2 X X +CAMK2A CAMK2A Q9UQM7 human rabphilin 3A 171039 P47709 Rph3a rat S274 455801 QGLRRANsVQASRPA X +CAMK2A CAMK2A Q9UQM7 human GluR4 29629 P19493 Gria4 rat S862 448810 TRNKARLsITGSVGE X +CAMK2A CAMK2A Q9UQM7 human SCN5A 6331 Q14524 SCN5A human S1865 40413915 TKRVLGEsGEMDALK X +CAMK2A CAMK2A Q9UQM7 human gephyrin 64845 Q03555 Gphn rat S335 18910590 KENILRAsHsAVDIT X +CAMK2A CAMK2A Q9UQM7 human LRP4 83469 Q9QYP1 Lrp4 rat S1887 465668 TTPERRGsLPDTGWK X +CAMK2A CAMK2A Q9UQM7 human SCN5A 6331 Q14524 SCN5A human S2007 34355964 DLADFPPsPDRDRES X +CAMK2A CAMK2A Q9UQM7 human CACNA1S 100009585 P07293 CACNA1S rabbit S1575 6064601 PEIRRTIsGDLtAEE X +CAMK2A CAMK2A Q9UQM7 human PLB 414755 P61012 PLN dog S16 448114 RSAIRRAstIEMPQQ Phospholamban X 8496 +CAMK2A CAMK2A Q9UQM7 human Vimentin 280955 P48616 VIM cow S39 451766 TTSTRTYsLGSALRP Filament_head X +CAMK2A CAMK2A Q9UQM7 human SynGAP 192117 Q9QUH6 Syngap1 rat S1138 451016 PSITkQHsQTPSTLN DUF3498 X +CAMK2A CAMK2A Q9UQM7 human sarcolipin 66402 Q9CQD6 Sln mouse T5 459214 ___MERStQELFINF Sarcolipin X +CAMK2A CAMK2A Q9UQM7 human Kv4.2 Q63881 Kcnd2 rat S438 2906103 ARIRAAksGSANAYM X X +CAMK2A CAMK2A Q9UQM7 human CYLD 1540 Q9NQC7 CYLD human S772 31957308 LFKkIFPsLELNITD UCH X X +CAMK2A CAMK2A Q9UQM7 human CD44 960 P16070 CD44 human S706 450988 LNGEAsksQEMVHLV X X +CAMK2A CAMK2A Q9UQM7 human GJC1 14615 P28229 Gjc1 mouse S385 22598809 SNKssIssKsGDGKT X +CAMK2A CAMK2A Q9UQM7 human NOX5 iso4 79400 Q96PH1-4 NOX5 human S502 20612402 MRKsQRSsKGSEILL FAD_binding_8 X +CAMK2A CAMK2A Q9UQM7 human GJC1 14615 P28229 Gjc1 mouse T337 22598811 HLPADLEtLQREIRM X +CAMK2A CAMK2A Q9UQM7 human VEGFR2 16542 P35918 Kdr mouse S982 10940352 FVEEKSLsDVEEEEA PK_Tyr_Ser-Thr X +CAMK2A CAMK2A Q9UQM7 human CREB 12912 Q01147 Creb1 mouse S119 448228 EILsRRPsyRkILND pKID X 9187; 9196; 9198; 4095; 14228; 14001; 39561; 80120; 44864; 54960; 95995 +CAMK2A CAMK2A Q9UQM7 human HDAC5 84580 F1LM64 Hdac5 rat S322 447996 RPLSRTQsSPLPQSP X +CAMK2A CAMK2A Q9UQM7 human separase 9700 Q14674 ESPL1 human S1501 447668 TDNWRKMsFEILRGs X +CAMK2A CAMK2A Q9UQM7 human NETO2 307757 C6K2K4 Neto2 rat S409 4752528 SLREKEIsADLADLS X X +CAMK2A CAMK2A Q9UQM7 human CACNA1H 8912 O95180 CACNA1H human S1198 22648004 tPLRRAEsLDPRPLR X +CAMK2A CAMK2A Q9UQM7 human TH iso3 7054 P07101-3 TH human S40 448545 RFIGRRQsLIEDARK TOH_N X 2791 +CAMK2A CAMK2A Q9UQM7 human LRP4 83469 Q9QYP1 Lrp4 rat S1900 465667 WKHERKLsSESQV__ X +CAMK2A CAMK2A Q9UQM7 human PSD-95 1742 P78352 DLG4 human S73 471390 ITLERGNsGLGFsIA PDZ X +CAMK2A CAMK2A Q9UQM7 human CPEB3 208922 Q7TN99 Cpeb3 mouse S299 25734913 PLKKPFssNVIAPPK X +CAMK2A CAMK2A Q9UQM7 human SCN5A 6331 Q14524 SCN5A human S1503 9993604 NAMKKLGsKKPQKPI X +CAMK2A CAMK2A Q9UQM7 human beclin 1 8678 Q14457 BECN1 human S93 5473540 ARMMstEsANsFTLI X 14717 +CAMK2A CAMK2A Q9UQM7 human SCN5A 6331 Q14524 SCN5A human S471 10404937 sPLAPVNsHERRsKR X +CAMK2A CAMK2A Q9UQM7 human BRSK1 499073 B2DD29 Brsk1 rat T189 456027 VGDSLLEtSCGSPHY Pkinase X X +CAMK2A CAMK2A Q9UQM7 human Securin 9232 O95997 PTTG1 human T66 33663901 AtRkALGtVNRATEK Securin X +CAMK2A CAMK2A Q9UQM7 human GJC1 14615 P28229 Gjc1 mouse S387 22598806 KssIssKsGDGKTsV X +CAMK2A CAMK2A Q9UQM7 human H1R 3269 P35367 HRH1 human S396 453404 FTWKRLRsHsRQyVS 7tm_1 X +CAMK2A CAMK2A Q9UQM7 human Ets-2 2114 P15036 ETS2 human S246 7113802 FPkSRLSsVsVTYCS Ets1_N_flank X +CAMK2A CAMK2A Q9UQM7 human beclin 1 8678 Q14457 BECN1 human S90 472001 IPPARMMstEsANsF X X 29362; 86455 +CAMK2A CAMK2A Q9UQM7 human SPR 29270 P18297 Spr rat S196 469985 EPSVRVLsYAPGPLD adh_short X +CAMK2A CAMK2A Q9UQM7 human CACNA1C 100101555 P15381 CACB rabbit S1517 460572 DYLTRDWsILGPHHL Ion_trans X +CAMK2A CAMK2A Q9UQM7 human SCN5A 6331 Q14524 SCN5A human S1998 40413911 RGSDYSHsEDLADFP X +CAMK2A CAMK2A Q9UQM7 human Caldesmon 373965 P12957 CALD1 chicken S73 457422 SEVNAQNsVAEEETK Caldesmon X +CAMK2A CAMK2A Q9UQM7 human SCN5A 6331 Q14524 SCN5A human S1003 40413908 AAQGQLPsCIATPYS Na_trans_assoc X +CAMK2A CAMK2A Q9UQM7 human RYR2 689560 B0LPN4 Ryr2 rat S2798 448848 yNRTRRIsQTsQVsI X +CAMK2A CAMK2A Q9UQM7 human CACNA1C 100101555 P15381 CACB rabbit S439 460571 GVLSGEFsKEREKAK Ion_trans X +CAMK2A CAMK2A Q9UQM7 human Caldesmon 373965 P12957 CALD1 chicken S635 457432 AVVsKIDsRLEQyTs Caldesmon X +CAMK2A CAMK2A Q9UQM7 human TRPV1 83810 O35433 Trpv1 rat T704 487542 WKLQRAItILDTEKS X +CAMK2A CAMK2A Q9UQM7 human CTNNB1 1499 P35222 CTNNB1 human T472 3653236 ICALRHLtsRHQEAE Arm X +CAMK2A CAMK2A Q9UQM7 human NMDAR2B 2904 Q13224 GRIN2B human S1303 450171 NKLRRQHsyDtFVDL NMDAR2_C X 20274; 71335 +CAMK2A CAMK2A Q9UQM7 human Tau 281296 P29172 MAPT cow S423 454127 SNVSSTGsIDMVDSP X 15013; 61160 +CAMK2A CAMK2A Q9UQM7 human myelin P0 539462 P10522 MPZ cow S210 458930 HKTAKDAsKRGRQTP Myelin-PO_C X +CAMK2A CAMK2A Q9UQM7 human WEE1B 381759 Q66JT0 Wee2 mouse S15 456697 QGLNKKLsFSFCEED X X +CAMK2A CAMK2A Q9UQM7 human GluR1 2890 P42261 GRIA1 human S567 17934900 FSPYEWHsEEFEEGR Lig_chan X +CAMK2A CAMK2A Q9UQM7 human GLO1 2739 Q04760 GLO1 human T107 7106304 ELTHNWGtEDDETQS Glyoxalase X +CAMK2A CAMK2A Q9UQM7 human RYR2 6262 Q92736 RYR2 human S2808 448848 YNRTRRIsQTSQVsV X +CAMK2A CAMK2A Q9UQM7 human SNCA 6622 P37840 SNCA human S129 448278 NEAyEMPsEEGyQDy Synuclein X 23706; 87281 +CAMK2A CAMK2A Q9UQM7 human Tau iso8 4137 P10636-8 MAPT human S262 447930 NVKskIGstENLkHQ Tubulin-binding X +CAMK2A CAMK2A Q9UQM7 human Tau iso8 4137 P10636-8 MAPT human S416 454127 sNVsstGsIDMVDsP X 15013; 61160 +CAMK2A CAMK2A Q9UQM7 human H1R 3269 P35367 HRH1 human T140 453406 LRYLKYRtKtRASAT 7tm_1 X +CAMK2A CAMK2A Q9UQM7 human CREB iso1 81646 P15337-1 Creb1 rat S142 448547 RkILNDLssDAPGVP pKID X +CAMK2A CAMK2A Q9UQM7 human mAChR M4 25111 P08485 Chrm4 rat T145 14699600 TYPARRTtKMAGLMI 7tm_1 X X +CAMK2A CAMK2A Q9UQM7 human TH iso3 7054 P07101-3 TH human S19 448542 KGFRRAVsELDAKQA TOH_N X +CAMK2A CAMK2A Q9UQM7 human CDK5R1 116671 P61810 Cdk5r1 rat S91 12607404 ENLKKSLsCANLSTF X +CAMK2A CAMK2A Q9UQM7 human smMLCK 396445 P11799 MYLK chicken S1749 466361 RAIGRLSsMAMISGM X +CAMK2A CAMK2A Q9UQM7 human GJA1 24392 P08050 Gja1 rat S369 459208 RPssRAssRAssRPR X +CAMK2A CAMK2A Q9UQM7 human FosB 14282 P13346 Fosb mouse S27 465535 SAESQYLsSVDSFGS X +CAMK2A CAMK2A Q9UQM7 human NSDDR 747 Q9Y4D2 DAGLA human S808 27807806 RSIRGsPsLHAVLER X +CAMK2A CAMK2A Q9UQM7 human SPTBN4 57731 Q9H254 SPTBN4 human S2254 481487 RRPERQEsVDQSEEA X +CAMK2A CAMK2A Q9UQM7 human PPP2R2B iso2 5521 Q00005-2 PPP2R2B human S20 25554903 RPPNTILsssCHTEA X +CAMK2A CAMK2A Q9UQM7 human RPT6 81827 P62198 Psmc5 rat S120 483970 RVALRNDsYTLHKIL Prot_ATP_ID_OB X +CAMK2A CAMK2A Q9UQM7 human NOX5 iso4 79400 Q96PH1-4 NOX5 human T494 472625 KRLsRSVtMRKsQRS FAD_binding_8 X +CAMK2A CAMK2A Q9UQM7 human SCN5A 6331 Q14524 SCN5A human T570 40413907 VPWPLRRtsAQGQPs Na_trans_cytopl X +CAMK2A CAMK2A Q9UQM7 human CPEB3 208922 Q7TN99 Cpeb3 mouse S291 25288000 PsPLNPIsPLKKPFs X +CAMK2A CAMK2A Q9UQM7 human PEA-15 100736554 Q9Z297 Pea15 hamster S116 450281 KDIIRQPsEEEIIKL X +CAMK2A CAMK2A Q9UQM7 human GluR1 50592 P19490 Gria1 rat S645 471090 LTVERMVsPIESAED Lig_chan X +CAMK2A CAMK2A Q9UQM7 human GJA1 24392 P08050 Gja1 rat S297 465458 TGDRNNssCRNYNkQ Connexin43 X +CAMK2A CAMK2A Q9UQM7 human FAK 14083 P34152 Ptk2 mouse S843 447963 DVRLsRGsIDREDGS X +CAMK2A CAMK2A Q9UQM7 human CPEB3 208922 Q7TN99 Cpeb3 mouse S443 2658904 QALssGLssPtRCQN X +CAMK2A CAMK2A Q9UQM7 human GJA1 24392 P08050 Gja1 rat S244 17743400 KDRVKGRsDPyHATT X +CAMK2A CAMK2A Q9UQM7 human Kir6.2 3767 Q14654 KCNJ11 human T224 453090 MQVVRKTtSPEGEVV IRK_C X X +CAMK2A CAMK2A Q9UQM7 human SCN5A 6331 Q14524 SCN5A human S664 27281501 GARQRALsAVsVLts Na_trans_cytopl X +CAMK2A CAMK2A Q9UQM7 human GJC1 14615 P28229 Gjc1 mouse S393 22598810 KsGDGKTsVWI____ X +CAMK2A CAMK2A Q9UQM7 human SCN5A 6331 Q14524 SCN5A human S42 27281503 GSTTLQEsREGLPEE X +CAMK2A CAMK2A Q9UQM7 human SCN5A 6331 Q14524 SCN5A human S499 40413912 DRLPKsDsEDGPRAM X +CAMK2A CAMK2A Q9UQM7 human Securin 9232 O95997 PTTG1 human S87 3845109 PLKQKQPsFsAKKMT Securin X +CAMK2A CAMK2A Q9UQM7 human PLB 5350 P26678 PLN human T17 448115 SAIRRAstIEMPQQA Phospholamban X 8496 +CAMK2A CAMK2A Q9UQM7 human Caldesmon 373965 P12957 CALD1 chicken S490 457429 LtTPKLKsTENAFGR Caldesmon X +CAMK2A CAMK2A Q9UQM7 human RYR2 20191 E9Q401 Ryr2 mouse S2807 448848 YNRTRRIsQtsQVsI X +CAMK2A CAMK2A Q9UQM7 human Telethonin 8557 O15273 TCAP human S161 3893741 RsLsRSMsQEAQRG_ Telethonin X +CAMK2A CAMK2A Q9UQM7 human PPP2R2B iso2 5521 Q00005-2 PPP2R2B human S21 25554901 PPNTILsssCHTEAD X +CAMK2A CAMK2A Q9UQM7 human HDAC5 84580 F1LM64 Hdac5 rat S83 447995 FPLRKTAsEPNLKVR X +CAMK2A CAMK2A Q9UQM7 human Ets-1 2113 P14921 ETS1 human S251 449316 GkLGGQDsFEsIEsy Ets1_N_flank X X +CSNK2A1 CK2A1 P68400 human RIGI 23586 O95786 RIGI human S854 17484202 HPKPkQFssFEkRAK RIG-I_C-RD X X +CSNK2A1 CK2A1 P68400 human PAK1 5058 Q13153 PAK1 human S223 454121 DVAtsPIsPtENNtt X X +CSNK2A1 CK2A1 P68400 human HMGA2 15364 P52927 Hmga2 mouse S101 469757 QETEEtssQEsAEED X +CSNK2A1 CK2A1 P68400 human ataxin-3 110616 Q9CVD2 Atxn3 mouse S29 13421402 LLQGEYFsPVELSSI Josephin X X +CSNK2A1 CK2A1 P68400 human DDIT3 1649 P35638 DDIT3 human S31 455504 DLQEVLssDENGGTY X +CSNK2A1 CK2A1 P68400 human CD10 4311 P08473 MME human S6 3850156 __MGKsEsQMDItDI X X +CSNK2A1 CK2A1 P68400 human PTEN 5728 P60484 PTEN human S380 448313 EPDHyRYsDttDsDP X 9551; 9554; 9549; 7960 +CSNK2A1 CK2A1 P68400 human MSK1 9252 O75582 RPS6KA5 human S760 12159002 TETRssssESSHSsS X +CSNK2A1 CK2A1 P68400 human PPP1R2 5504 P41236 PPP1R2 human S87 449054 GDDEDACsDtEAtEA IPP-2 X +CSNK2A1 CK2A1 P68400 human CFTR 12638 P26361 Cftr mouse S670 3333405 TETLRRFsVDDSSAP CFTR_R X +CSNK2A1 CK2A1 P68400 human caveolin-2 858 P51636 CAV2 human S36 469561 DPEKFADsDQDRDPH Caveolin X X +CSNK2A1 CK2A1 P68400 human SPTBN1 6711 Q01082 SPTBN1 human S2110 471398 PEPstKVsEEAEsQQ X +CSNK2A1 CK2A1 P68400 human NHE3 100009430 P26432 NHE-3 rabbit S554 450899 TEGERRGsLAFIRSP X +CSNK2A1 CK2A1 P68400 human IRS1 25467 P35570 Irs1 rat S612 447562 DDGyMPMsPGVAPVP X 3193; 2386; 3203 +CSNK2A1 CK2A1 P68400 human Sialoprotein-2 281233 Q28862 IBSP cow S86 457544 EEEEEETsNEEGNNG BSP_II X +CSNK2A1 CK2A1 P68400 human PER2 18627 O54943 Per2 mouse S53 9439800 TGRDSQGsDCDDNGK X X +CSNK2A1 CK2A1 P68400 human 14-3-3 theta 10971 P27348 YWHAQ human S232 456053 LTLWtsDsAGEECDA X +CSNK2A1 CK2A1 P68400 human FAF1 11124 Q9UNN5 FAF1 human S291 450287 DVHMVsDsDGDDFED X +CSNK2A1 CK2A1 P68400 human MYH10 4628 P35580 MYH10 human S1956 465600 EGAsLELsDDDtEsK X +CSNK2A1 CK2A1 P68400 human CREB iso1 81646 P15337-1 Creb1 rat S111 451808 TIAEsEDsQEsVDsV X +CSNK2A1 CK2A1 P68400 human ZC3H8 84524 Q8N5P1 ZC3H8 human T32 3206328 RIDDEIDtEVEETQE X +CSNK2A1 CK2A1 P68400 human CDC27 996 P30260 CDC27 human S154 18258506 FLWSPFEsLCEIGEK X +CSNK2A1 CK2A1 P68400 human occludin 100506658 Q16625 OCLN human T404 471472 HyEtDyttGGEsCDE X X +CSNK2A1 CK2A1 P68400 human Calmodulin 24242 P0DP29 Calm3 rat S102 448706 kDGNGyIsAAELRHV EF-hand_7 X X +CSNK2A1 CK2A1 P68400 human Sialoprotein-2 281233 Q28862 IBSP cow S106 467257 DENEDEEsEAENTTL BSP_II X +CSNK2A1 CK2A1 P68400 human TDP-43 23435 Q13148 TARDBP human S379 3084615 NSYsGsNsGAAIGWG X +CSNK2A1 CK2A1 P68400 human NCAM-L1 3897 P32004 L1CAM human S1181 465573 GEyRSLEsDNEEKAF Bravo_FIGEY X +CSNK2A1 CK2A1 P68400 human XRCC1 7515 P18887 XRCC1 human T488 451452 GAEDsGDtEDELRRV X X +CSNK2A1 CK2A1 P68400 human GRB14 2888 Q14449 GRB14 human S362 31834912 QGRsGCSsQSIsPMR X +CSNK2A1 CK2A1 P68400 human CBX1 10951 P83916 CBX1 human T51 2753801 GFSDEDNtWEPEENL Chromo X X +CSNK2A1 CK2A1 P68400 human RP1 10982 Q15555 MAPRE2 human S236 23140241 SSGSASksDkDLETQ X X +CSNK2A1 CK2A1 P68400 human SQSTM1 8878 Q13501 SQSTM1 human S403 22264800 ESLSQMLsMGFsDEG UBA_5 X X 39786 +CSNK2A1 CK2A1 P68400 human ER-alpha 2099 P03372 ESR1 human S282 6048401 EGrGEVGsAGDMRAA X X +CSNK2A1 CK2A1 P68400 human ATF-4 468 P18848 ATF4 human S184 1876136802 SFSLELGsEVDITEG X +CSNK2A1 CK2A1 P68400 human treacle 6949 Q13428 TCOF1 human T210 35530406 TSSSSDEtDVEGKPS X X +CSNK2A1 CK2A1 P68400 human ECE1 iso3 1889 P42892-3 ECE1 human S20 3053606 EDLVDsLsEGDAYPN X X +CSNK2A1 CK2A1 P68400 human XRCC1 7515 P18887 XRCC1 human S421 3181474 EAsHsGGsGDEAPKL X +CSNK2A1 CK2A1 P68400 human RPS5 20103 P97461 Rps5 mouse S34 9819907 DVQINDIsLQDYIAV X +CSNK2A1 CK2A1 P68400 human PACS2 23241 Q86VP3 PACS2 human S207 1884003500 EEEYESFssEQEAsD X X +CSNK2A1 CK2A1 P68400 human VTN 7448 P04004 VTN human T76 451404 tMPEDEytVYDDGEE X +CSNK2A1 CK2A1 P68400 human DARPP-32 360616 Q6J4I0 Ppp1r1b rat S45 465607 LFRVSEHssPEEESS DARPP-32 X +CSNK2A1 CK2A1 P68400 human N-WASP 682507 O08816 Wasl rat S481 3149547 RSKAIHssDEDEDDD X X +CSNK2A1 CK2A1 P68400 human RNPS1 10921 Q15287 RNPS1 human S53 455347 KGATKEssEKDRGRD X X +CSNK2A1 CK2A1 P68400 human CTNNA1 1495 P35221 CTNNA1 human S641 449139 tPEELDDsDFEtEDF Vinculin X X +CSNK2A1 CK2A1 P68400 human SMRT 9612 Q9Y618 NCOR2 human S2511 465590 CSQYETLsDsE____ X +CSNK2A1 CK2A1 P68400 human YY1 7528 P25490 YY1 human S118 460025 EVVGGDDsDGLRAED X X +CSNK2A1 CK2A1 P68400 human WASP 7454 P42768 WAS human S483 449294 KRSRAIHssDEGEDQ X X +CSNK2A1 CK2A1 P68400 human ARC 8996 O60936 NOL3 human T149 448618 SEAVQSGtPEEPEPE X +CSNK2A1 CK2A1 P68400 human DNAJB2 3300 P25686 DNAJB2 human S247 34505486 PASCPLDsDLsEDED X +CSNK2A1 CK2A1 P68400 human STAT1 6772 P42224 STAT1 human S727 447753 TDNLLPMsPEEFDEV STAT1_TAZ2bind X 9177; 8826; 62390 +CSNK2A1 CK2A1 P68400 human LASS5 91012 Q8N5B7 CERS5 human S356 18260888 RsDVEsssEEEDVTT X +CSNK2A1 CK2A1 P68400 human ECE1 iso3 1889 P42892-3 ECE1 human S18 3053605 DEEDLVDsLsEGDAY X X +CSNK2A1 CK2A1 P68400 human IRS1 25467 P35570 Irs1 rat T502 449932 MGTsPALtGDEAAGA X +CSNK2A1 CK2A1 P68400 human CACNA1C 100101555 P15381 CACB rabbit T1704 17620920 RAIsGDLtAEEELDK CAC1F_C X +CSNK2A1 CK2A1 P68400 human NCL 17975 P09405 Ncl mouse S28 452262 PKEVEEDsEDEEMsE X +CSNK2A1 CK2A1 P68400 human EIF5 1983 P55010 EIF5 human T207 3339005 DDDWGEDttEEAQRR X +CSNK2A1 CK2A1 P68400 human DOK7 231134 Q18PE0 Dok7 mouse S266 41621606 DDRSLsssSSEASHs X +CSNK2A1 CK2A1 P68400 human CDH1 12550 P09803 Cdh1 mouse S840 465565 LVFDYEGsGsEAAsL CADH_Y-type_LIR X +CSNK2A1 CK2A1 P68400 human SLITRK1 114798 Q96PX8 SLITRK1 human S695 4749248 DCGSHSLsD______ X +CSNK2A1 CK2A1 P68400 human HMGN1 3150 P05114 HMGN1 human S99 451698 AGEkEAksD______ X +CSNK2A1 CK2A1 P68400 human PACS-1 55690 Q6VY07 PACS1 human S278 2911721 SPDIDNYsEEEEESF X +CSNK2A1 CK2A1 P68400 human Ikaros 22778 Q03267 Ikzf1 mouse T23 4828303 ESPPVSDtPDEGDEP X +CSNK2A1 CK2A1 P68400 human PLD1 5337 Q13393 PLD1 human S611 465587 FKLFHPssESEQGLT X +CSNK2A1 CK2A1 P68400 human MRE11A 4361 P49959 MRE11 human S688 449207 sKGVDFEssEDDDDD X X +CSNK2A1 CK2A1 P68400 human MCR 4306 P08235 NR3C2 human S111 386186601 SMGLYMDsVRDADYS X X +CSNK2A1 CK2A1 P68400 human JNK2 5601 P45984 MAPK9 human S407 447648 STEQtLAsDTDSSLD X +CSNK2A1 CK2A1 P68400 human Jun 3725 P05412 JUN human S243 450451 PGEtPPLsPIDMEsQ X 2994 +CSNK2A1 CK2A1 P68400 human p47phox 653361 P14598 NCF1 human S348 451728 PGPQsPGsPLEEERQ X +CSNK2A1 CK2A1 P68400 human ATF-1 466 P18846 ATF1 human S47 15725601 EsQDSSDsIGssQKA pKID X +CSNK2A1 CK2A1 P68400 human N-WASP 682507 O08816 Wasl rat S480 3149548 KRSKAIHssDEDEDD X X +CSNK2A1 CK2A1 P68400 human OTUB1 55611 Q96FW1 OTUB1 human S16 3208998 QkQEPLGsDsEGVNC X X +CSNK2A1 CK2A1 P68400 human MRTO4 51154 Q9UKD2 MRTO4 human S235 22349546 EsTEEsDsEDDD___ X +CSNK2A1 CK2A1 P68400 human RIC8A 293614 Q80ZG1 Ric8a rat S435 468627 GRPEGQYsEDEDtDT Ric8 X +CSNK2A1 CK2A1 P68400 human FANCD2 2177 Q9BXW9 FANCD2 human S891 1871613601 tLsEEkNsECDPtPs FancD2 X +CSNK2A1 CK2A1 P68400 human TLE1 7088 Q04724 TLE1 human S239 454385 KDSsHYDsDGDKsDD X X +CSNK2A1 CK2A1 P68400 human CDH1 999 P12830 CDH1 human S850 1270900 AsLSsLNsSEsDKDQ CADH_Y-type_LIR X +CSNK2A1 CK2A1 P68400 human TDP-43 23435 Q13148 TARDBP human S410 3084601 ssMDskssGWGM___ X +CSNK2A1 CK2A1 P68400 human BMI1 648 P35226 BMI1 human S110 56654163 SADAANGsNEDrGEV X +CSNK2A1 CK2A1 P68400 human WAVE2 10163 Q9Y6W5 WASF2 human S497 6377639 EFDEDDWsD______ X +CSNK2A1 CK2A1 P68400 human AIP 9049 O00170 AIP human S43 10888700 FHYRTLHsDDEGTVL FKBP_C X +CSNK2A1 CK2A1 P68400 human SLC18A2 25549 Q01827 Slc18a2 rat S514 465596 GDDEEsEsD______ X +CSNK2A1 CK2A1 P68400 human calsequestrin 2 845 O14958 CASQ2 human S385 1868253002 DDDDDDNsDEEDNDD X +CSNK2A1 CK2A1 P68400 human HMGA1 iso2 3159 P17096-2 HMGA1 human S92 452255 EGIsQEssEEEQ___ X +CSNK2A1 CK2A1 P68400 human NCAPH 23397 Q15003 NCAPH human S570 470129 PGLQAADsDDEDLDD Cnd2 X +CSNK2A1 CK2A1 P68400 human TINF2 26277 Q9BSI4 TINF2 human S396 17554823 IGDLVLDsDEEENGQ X +CSNK2A1 CK2A1 P68400 human HOXB7 3217 P09629 HOXB7 human S133 465570 IYPWMRssGTDRKRG X +CSNK2A1 CK2A1 P68400 human GMF-beta 2764 P60983 GMFB human S53 451488 DEELEGIsPDELkDE Cofilin_ADF X +CSNK2A1 CK2A1 P68400 human SLC3A2 6520 P08195 SLC3A2 human S408 6003503 TssyLsDsGsTGEHT X +CSNK2A1 CK2A1 P68400 human FMR1 2332 Q06787 FMR1 human S500 469583 NSEASNAsETESDHR FXMRP1_C_core X +CSNK2A1 CK2A1 P68400 human DNAJB2 3300 P25686 DNAJB2 human S250 34499810 CPLDsDLsEDEDLQL X X +CSNK2A1 CK2A1 P68400 human FAF1 11124 Q9UNN5 FAF1 human S289 450286 ITDVHMVsDsDGDDF X +CSNK2A1 CK2A1 P68400 human CFTR 12638 P26361 Cftr mouse S422 3333404 SNGDRKHsSDENNVS X +CSNK2A1 CK2A1 P68400 human LASS4 79603 Q9HA82 CERS4 human S342 7102766 QMEKDIRsDVEEsDs X +CSNK2A1 CK2A1 P68400 human MDC1 9656 Q14676 MDC1 human S218 4213800 PFAFNLNsDtDVEEG X +CSNK2A1 CK2A1 P68400 human RRAD 6236 P55042 RRAD human S257 457395 QIRLRRDsKEANARR X +CSNK2A1 CK2A1 P68400 human CD5 921 P06127 CD5 human S482 450126 SsMQPDNssDsDyDL X X +CSNK2A1 CK2A1 P68400 human APOE 348 P02649 APOE human S314 457115 tsAAPVPsDNH____ X +CSNK2A1 CK2A1 P68400 human FANCD2 2177 Q9BXW9 FANCD2 human S898 1871613602 sECDPtPsHRGQLNk FancD2 X +CSNK2A1 CK2A1 P68400 human CFTR 1080 P13569 CFTR human T421 1382554800 QNNNNRktsNGDDsL X +CSNK2A1 CK2A1 P68400 human DTD1 92675 Q8TEA8 DTD1 human S194 3072143 tPRKEDRsAssGAEG X +CSNK2A1 CK2A1 P68400 human GBF1 8729 Q92538 GBF1 human S297 1170755601 TDsGLEFsSQTTSKE X X +CSNK2A1 CK2A1 P68400 human PhLP 5082 Q13371 PDCL human S296 465538 AtCHsEDsDLEID__ Phosducin X +CSNK2A1 CK2A1 P68400 human HSP70 3303 P0DMV8 HSPA1B human T636 18010647 GGsGsGPtIEEVD__ X +CSNK2A1 CK2A1 P68400 human LASS6 253782 Q6ZMG9 CERS6 human S347 22350312 RsDIEsssDEEDSEP X +CSNK2A1 CK2A1 P68400 human caveolin-1 403980 P33724 CAV1 dog S88 451561 FDGIWKAsFTTFTVT Caveolin X +CSNK2A1 CK2A1 P68400 human HMGN1 3150 P05114 HMGN1 human S89 451697 ktEEsPAsDEAGEkE HMG14_17 X +CSNK2A1 CK2A1 P68400 human NFE2L1 18023 Q61985 Nfe2l1 mouse S497 28700306 EGAVGYSsDSETLDL X +CSNK2A1 CK2A1 P68400 human Calmodulin 801 P0DP23 CALM3 human S102 448706 kDGNGyIsAAELrHV EF-hand_7 X +CSNK2A1 CK2A1 P68400 human SSRP1 6749 Q08945 SSRP1 human S510 455268 SSSNEGDsDRDEKKR X +CSNK2A1 CK2A1 P68400 human HHEX 3087 Q03014 HHEX human S163 7430500 FETQKYLsPPERKRL Homeodomain X +CSNK2A1 CK2A1 P68400 human ITCH 16396 Q8C863 Itch mouse T425 470111 VNHNTRItQWEDPRS WW X +CSNK2A1 CK2A1 P68400 human NKX2-5 18091 P42582 Nkx2-5 mouse S163 465563 FKQQRYLsAPERDQL Homeodomain X +CSNK2A1 CK2A1 P68400 human IL16 3603 Q14005 IL16 human S743 11280302 MPLQPNAsLNEEEGT X +CSNK2A1 CK2A1 P68400 human GRB14 2888 Q14449 GRB14 human S358 31834913 MHPYQGRsGCSsQSI X +CSNK2A1 CK2A1 P68400 human MDC1 9656 Q14676 MDC1 human S402 3196337 QAsMVINsDtDDEEE X +CSNK2A1 CK2A1 P68400 human Jun 3725 P05412 JUN human S249 455367 LsPIDMEsQERIkAE X X +CSNK2A1 CK2A1 P68400 human DAXX 1616 Q9UER7 DAXX human S737 467726 PEEIIVLsDsD____ X X +CSNK2A1 CK2A1 P68400 human MSK1 9252 O75582 RPS6KA5 human S757 12159001 stsTETRssssESSH X +CSNK2A1 CK2A1 P68400 human PLD1 5337 Q13393 PLD1 human S610 465586 HFKLFHPssESEQGL X +CSNK2A1 CK2A1 P68400 human PAX7 18509 P47239 Pax7 mouse S201 50592106 GNRLDEGsDVEsEPd X +CSNK2A1 CK2A1 P68400 human SSRP1 6749 Q08945 SSRP1 human S688 456296 KRRRSEDsEEEELAS X +CSNK2A1 CK2A1 P68400 human NHE5 6553 Q14940 SLC9A5 human S712 20832301 EEEEsDssEtEKEDD X +CSNK2A1 CK2A1 P68400 human PSEN2 5664 P49810 PSEN2 human S9 449961 LTFMAsDsEEEVCDE X +CSNK2A1 CK2A1 P68400 human XRCC1 7515 P18887 XRCC1 human S418 3181471 EEDEAsHsGGsGDEA X +CSNK2A1 CK2A1 P68400 human ATF-4 468 P18848 ATF4 human S215 27833501 IKEEDTPsDNDsGIC X X +CSNK2A1 CK2A1 P68400 human AQP4 25293 P47863 Aqp4 rat S285 449922 MEVEDNRsQVEtEDL X +CSNK2A1 CK2A1 P68400 human SHOX 6473 O15266 SHOX human S106 457680 EKREDVKsEDEDGQT X X +CSNK2A1 CK2A1 P68400 human IHPK2 51447 Q9UHH9 IP6K2 human S356 18258507 AEDLEDLsEEsADES IPK X +CSNK2A1 CK2A1 P68400 human PPAR-gamma iso2 19016 P37238-2 Pparg mouse S21 12170301 GIsSVDLsVMEDHSH PPARgamma_N X +CSNK2A1 CK2A1 P68400 human IkB-alpha 4792 P25963 NFKBIA human S36 448204 RHDsGLDsMkDEEyE X 5210; 9246 +CSNK2A1 CK2A1 P68400 human PTPRCAP 5790 Q14761 PTPRCAP human S153 23136094 RAEEARDsDtEGDLV PTPRCAP X X +CSNK2A1 CK2A1 P68400 human DNAJC1 607587 F1PMR9 DNAJC1 dog S486 469721 DISEQKEssDEESQK X +CSNK2A1 CK2A1 P68400 human GRB14 2888 Q14449 GRB14 human S370 14567758 QSIsPMRsIsENsLV BPS X +CSNK2A1 CK2A1 P68400 human ARRB2 409 P32121 ARRB2 human T382 455373 EFDTNYAtDDDIVFE X +CSNK2A1 CK2A1 P68400 human PPP1R2 5504 P41236 PPP1R2 human S121 449052 yRIQEQEssGEEDsD IPP-2 X +CSNK2A1 CK2A1 P68400 human TOP1 7150 P11387 TOP1 human S506 27276101 ADTVGCCsLRVEHIN Topoisom_I X +CSNK2A1 CK2A1 P68400 human SRPK1 6732 Q96SB4 SRPK1 human S555 456013 DYLFEPHsGEEYTRD Pkinase X +CSNK2A1 CK2A1 P68400 human CADPS 26989 Q62717 Cadps rat S5 7712502 ___MLDPsssEEEsD X +CSNK2A1 CK2A1 P68400 human PIAS1 8554 O75925 PIAS1 human S467 4700788 IDLtIDsssDEEEEE X X +CSNK2A1 CK2A1 P68400 human MYH2 4620 Q9UKX2 MYH2 human S1921 3090700 ERADIAEsQVNKLRV Myosin_tail_1 X +CSNK2A1 CK2A1 P68400 human CADPS 26989 Q62717 Cadps rat S6 7712500 __MLDPsssEEEsDE X +CSNK2A1 CK2A1 P68400 human SCN2A 24766 P04775 Scn2a rat S1124 6003506 LNTEEFSsEsDMEES Na_trans_assoc X +CSNK2A1 CK2A1 P68400 human MYH10 4628 P35580 MYH10 human S1952 465599 QLHLEGAsLELsDDD X +CSNK2A1 CK2A1 P68400 human SIRT1 23411 Q96EB6 SIRT1 human S661 6855924 GAEVYsDsEDDVLSS X X +CSNK2A1 CK2A1 P68400 human PHF8 23133 Q9UPP1 PHF8 human S854 3216123 DAEYIyPsLEsDDDD X X +CSNK2A1 CK2A1 P68400 human SAT 6303 P21673 SAT1 human S146 11390100 FYKRRGAsDLsSEEG X +CSNK2A1 CK2A1 P68400 human TOP2A 7153 P11388 TOP2A human S1525 448764 PIKyLEEsDEDDLF_ X +CSNK2A1 CK2A1 P68400 human IGFBP1 3484 P08833 IGFBP1 human S144 451659 NFHLMAPsEEDHSIL X X +CSNK2A1 CK2A1 P68400 human ataxin-3 4287 P54252 ATXN3 human S347 9441000 LQAAVTMsLETVRND UIM X +CSNK2A1 CK2A1 P68400 human calsequestrin 1 100009095 P07221 CASQ1 rabbit T381 451337 VLEGEINtEDDDDED Calsequestrin X +CSNK2A1 CK2A1 P68400 human RIGI 23586 O95786 RIGI human T770 17484200 DsILRLQtWDEAVFR X X +CSNK2A1 CK2A1 P68400 human IGFBP3 3486 P17936 IGFBP3 human S194 10902818 KVDyEsQstDtQNFs X +CSNK2A1 CK2A1 P68400 human SMC3 9126 Q9UQE7 SMC3 human S1067 453059 GDVEGsQsQDEGEGs SMC_N X +CSNK2A1 CK2A1 P68400 human SSB 6741 P05455 SSB human S366 449301 GkktKFAsDDEHDEH X X +CSNK2A1 CK2A1 P68400 human IkB-alpha 4792 P25963 NFKBIA human S283 451523 NLQMLPEsEDEEsyD X X +CSNK2A1 CK2A1 P68400 human Myb 4602 P10242 MYB human S12 448187 PRHSIYssDEDDEDF X +CSNK2A1 CK2A1 P68400 human XRCC1 7515 P18887 XRCC1 human S416 3181468 ssEEDEAsHsGGsGD X +CSNK2A1 CK2A1 P68400 human BIK 638 Q13323 BIK human S35 448349 EVLGMtDsEEDLDPM bcl-2I13 X +CSNK2A1 CK2A1 P68400 human PhLP 5082 Q13371 PDCL human S25 465539 sssEDEDsDHEDKDR X X +CSNK2A1 CK2A1 P68400 human CK2B 1460 P67870 CSNK2B human S3 447647 _____MsssEEVsWI X +CSNK2A1 CK2A1 P68400 human XRCC1 7515 P18887 XRCC1 human S408 3181459 YLMAGPGsssEEDEA X +CSNK2A1 CK2A1 P68400 human LASS5 91012 Q8N5B7 CERS5 human S350 18260879 KVSKDDRsDVEsssE X +CSNK2A1 CK2A1 P68400 human MCR 4306 P08235 NR3C2 human S459 386186600 FMDGSYFsFMDDkDY X X +CSNK2A1 CK2A1 P68400 human MDC1 9656 Q14676 MDC1 human S299 477757 sQPPGEDsDtDVDDD X +CSNK2A1 CK2A1 P68400 human TPM1 22003 P58771 Tpm1 mouse S283 451804 HALNDMtsI______ Tropomyosin X +CSNK2A1 CK2A1 P68400 human CREB 1385 P16220 CREB1 human S97 451808 TIAEsEDsQEsVDsV X +CSNK2A1 CK2A1 P68400 human CTDP1 9150 Q9Y5B0 CTDP1 human S942 455466 ssNEDEGsssEADEM FCP1_C X +CSNK2A1 CK2A1 P68400 human MYH9 4627 P35579 MYH9 human S1916 451181 AMNREVssLkNkLRr Myosin_tail_1 X +CSNK2A1 CK2A1 P68400 human TELO2 9894 Q9Y4R8 TELO2 human S487 15668105 AQLAGsDsDLDsDDE X X +CSNK2A1 CK2A1 P68400 human GAP43 14432 P06837 Gap43 mouse S193 449598 PTEtAEssQAEEEkD Neuromodulin X +CSNK2A1 CK2A1 P68400 human CBX1 12412 P83917 Cbx1 mouse S89 2906737 GGkRKADsDsEDKGE X +CSNK2A1 CK2A1 P68400 human MRE11A 4361 P49959 MRE11 human S558 3191332 AEQMANDsDDsISAA X X +CSNK2A1 CK2A1 P68400 human Sialoprotein-2 281233 Q28862 IBSP cow S76 457543 ENGNGDssEEEEEEE BSP_II X +CSNK2A1 CK2A1 P68400 human TRHR 25570 Q01717 Trhr rat S383 465594 YVsTtKVsFDDtCLA X +CSNK2A1 CK2A1 P68400 human TIF1A 54700 Q9NYV6 RRN3 human S170 470001 KEGDVDVsDsDDEDD RRN3 X X +CSNK2A1 CK2A1 P68400 human NCL 25135 P13383 Ncl rat S213 466007 EEEEEDDsEEEVMEI X +CSNK2A1 CK2A1 P68400 human DDHD1 338047 O46606 DDHD1 cow S716 465583 AKDPTSIsENEGIST DDHD X +CSNK2A1 CK2A1 P68400 human ataxin-3 iso1 4287 P54252-1 ATXN3 human S236 9441003 LQRALALsRQEIDME UIM X +CSNK2A1 CK2A1 P68400 human Calmodulin 24242 P0DP29 Calm3 rat T80 448704 MARKMkDtDsEEEIR X X +CSNK2A1 CK2A1 P68400 human CADPS 26989 Q62717 Cadps rat S7 7712501 _MLDPsssEEEsDEI X +CSNK2A1 CK2A1 P68400 human PER2 18627 O54943 Per2 mouse S693 468399 ETVEDMAsGPEsLDG X X +CSNK2A1 CK2A1 P68400 human ABCB1B 18669 P06795 Abcb1b mouse S665 22634902 KsPLIRRsIYRsVHR X +CSNK2A1 CK2A1 P68400 human FUNDC1 139341 Q8IVP5 FUNDC1 human S13 2025373 PPPQDyEsDDDsyEV X X +CSNK2A1 CK2A1 P68400 human PIAS1 8554 O75925 PIAS1 human S466 4700782 VIDLtIDsssDEEEE X X +CSNK2A1 CK2A1 P68400 human XRCC1 7515 P18887 XRCC1 human S485 451510 QDNGAEDsGDtEDEL X X +CSNK2A1 CK2A1 P68400 human HSP105 15505 Q61699 Hsph1 mouse S509 448756 PtEEEDGssLEADME HSP70 X +CSNK2A1 CK2A1 P68400 human PAR-4 5074 Q96IZ0 PAWR human S231 476476 GRyksttsVsEEDVS X +CSNK2A1 CK2A1 P68400 human MDM2 4193 Q00987 MDM2 human S260 454923 sLDsEDYsLsEEGQE X +CSNK2A1 CK2A1 P68400 human ataxin-3 4287 P54252 ATXN3 human S335 9441001 SDLGDAMsEEDMLQA UIM X +CSNK2A1 CK2A1 P68400 human CTCF 396274 Q08705 CTCF chicken S604 448302 GRKRKMRsKKEDssD X +CSNK2A1 CK2A1 P68400 human Sialoprotein-2 281233 Q28862 IBSP cow S67 457541 VQsSsDssEENGNGD BSP_II X +CSNK2A1 CK2A1 P68400 human SLC28A2 60423 Q62773 Slc28a2 rat S46 4700175 EEVTQGHsLKDGLGH X +CSNK2A1 CK2A1 P68400 human STARD10 10809 Q9Y365 STARD10 human S284 483984 GGAGGEGsDDDtsLt X +CSNK2A1 CK2A1 P68400 human DMBT1 12945 Q60997 Dmbt1 mouse T2073 13201902 AFTLGRRtHIDRGQP X +CSNK2A1 CK2A1 P68400 human NHE3 100009430 P26432 NHE-3 rabbit S719 3496800 KERELELsDPEEAPD X X +CSNK2A1 CK2A1 P68400 human HOXB7 3217 P09629 HOXB7 human T203 465571 NKTAGPGttGQDRAE X +CSNK2A1 CK2A1 P68400 human HMGN1 614915 P02316 HMGN1 cow S90 451697 KNEESPAsDEAEEKE HMG14_17 X +CSNK2A1 CK2A1 P68400 human HMGA1 iso2 3159 P17096-2 HMGA1 human S91 452254 EEGIsQEssEEEQ__ X +CSNK2A1 CK2A1 P68400 human OAZ2 18247 O08608 Oaz2 mouse S186 11507801 YPLDQNLsDED____ X +CSNK2A1 CK2A1 P68400 human HOXB7 3217 P09629 HOXB7 human T204 465572 KTAGPGttGQDRAEA X +CSNK2A1 CK2A1 P68400 human RIC8A 293614 Q80ZG1 Ric8a rat T440 468628 QYsEDEDtDTEEYRE Ric8 X +CSNK2A1 CK2A1 P68400 human TRF1 7013 P54274 TERF1 human T122 2481000 LTACQLRtIYICQFL TRF X X +CSNK2A1 CK2A1 P68400 human H2A.1 8329 P0C0S8 H2AC17 human Y57 1874775700 YLAAVLEyLTAEILE Histone X X +CSNK2A1 CK2A1 P68400 human SCN2A 24766 P04775 Scn2a rat S1126 6003507 TEEFSsEsDMEESKE Na_trans_assoc X +CSNK2A1 CK2A1 P68400 human NPHP1 4867 O15259 NPHP1 human S126 26395105 EEsEsEDsEDSGGEE X X +CSNK2A1 CK2A1 P68400 human MUSK 18198 Q61006 Musk mouse S680 26367601 TVCSLSHsDLSTRAR PK_Tyr_Ser-Thr X +CSNK2A1 CK2A1 P68400 human LASS6 253782 Q6ZMG9 CERS6 human S341 40511820 KVSKDDRsDIEsssD X +CSNK2A1 CK2A1 P68400 human MDC1 9656 Q14676 MDC1 human S329 453669 QPFGFIDsDtDAEEE X +CSNK2A1 CK2A1 P68400 human IkB-alpha 4792 P25963 NFKBIA human S288 451524 PEsEDEEsyDtEsEF X X +CSNK2A1 CK2A1 P68400 human HSP90B 3326 P08238 HSP90AB1 human S718 3177650 LEGDEDAsRMEEVD_ X +CSNK2A1 CK2A1 P68400 human IRS1 25467 P35570 Irs1 rat S99 449931 HFAIAADsEAEQDSW PH X +CSNK2A1 CK2A1 P68400 human SLC3A2 6520 P08195 SLC3A2 human S527 6003505 LsLFRRLsDQRsKER X +CSNK2A1 CK2A1 P68400 human FOXC2 14234 Q61850 Foxc2 mouse S124 36950200 NSIRHNLsLNECFVK Forkhead X X +CSNK2A1 CK2A1 P68400 human MRLC2 103910 O14950 MYL12B human T135 466341 tTMGDrFtDEEVDEL EF-hand_11 X +CSNK2A1 CK2A1 P68400 human TELO2 9894 Q9Y4R8 TELO2 human S491 15668106 GsDsDLDsDDEFVPY X X +CSNK2A1 CK2A1 P68400 human Huntingtin 3064 P42858 HTT human S13 10206805 kLMkAFEsLksFQQQ X +CSNK2A1 CK2A1 P68400 human XRCC1 7515 P18887 XRCC1 human S475 451509 IDIEGVQsEGQDNGA X +CSNK2A1 CK2A1 P68400 human Akt1 207 P31749 AKT1 human S129 450019 sGsPsDNsGAEEMEV X X 13461 +CSNK2A1 CK2A1 P68400 human ACE 1636 P12821 ACE human S1299 450699 SHGPQFGsEVELRHS X +CSNK2A1 CK2A1 P68400 human MCM2 4171 P49736 MCM2 human S41 452312 RtDALtssPGRDLPP X +CSNK2A1 CK2A1 P68400 human CDC34 997 P49427 CDC34 human S203 448687 APAPDEGsDLFYDDY X X +CSNK2A1 CK2A1 P68400 human Lu 4059 P50895 BCAM human S598 1713901 GEPGLsHsGsEQPEQ X +CSNK2A1 CK2A1 P68400 human XRCC1 7515 P18887 XRCC1 human S578 40274402 GELEDYMsDRVQFVI BRCT_2 X +CSNK2A1 CK2A1 P68400 human RRAD 6236 P55042 RRAD human S273 457396 AGTRRREsLGKKAKR X +CSNK2A1 CK2A1 P68400 human TAP 317724 P41541 USO1 cow S941 450465 EEEDELEsGDQDDED Uso1_p115_C X +CSNK2A1 CK2A1 P68400 human DTD1 92675 Q8TEA8 DTD1 human S204 476435 sGAEGDVssErEP__ X +CSNK2A1 CK2A1 P68400 human MDC1 9656 Q14676 MDC1 human T220 4213801 AFNLNsDtDVEEGQQ X +CSNK2A1 CK2A1 P68400 human ABCF1 23 Q8NE71 ABCF1 human S140 454452 AALIQDQsEEEEEEE X +CSNK2A1 CK2A1 P68400 human XRCC1 7515 P18887 XRCC1 human S525 451451 stDENtDsEEHQEPP X +CSNK2A1 CK2A1 P68400 human DZIP1 66573 Q8BMD2 Dzip1 mouse S714 21241900 DTDWTEGsEMDDSDF X X +CSNK2A1 CK2A1 P68400 human CD6 923 P30203 CD6 human S482 28095003 PEDSDsGsDsDYEHY X +CSNK2A1 CK2A1 P68400 human HSP90A 3320 P07900 HSP90AA1 human S263 448662 PEIEDVGsDEEEEKK HSP90 X +CSNK2A1 CK2A1 P68400 human eIF3-alpha 8669 O75822 EIF3J human S127 3177700 LKkLQEEsDLELAkE eIF3_subunit X +CSNK2A1 CK2A1 P68400 human DNAJC1 607587 F1PMR9 DNAJC1 dog S487 469722 ISEQKEssDEESQKK X +CSNK2A1 CK2A1 P68400 human ATF-1 466 P18846 ATF1 human S36 465558 AQQVSSLsESEEsQD X X +CSNK2A1 CK2A1 P68400 human CARD9 64170 Q9H257 CARD9 human T531 1206001 NTTGSDNtDtEGS__ X X +CSNK2A1 CK2A1 P68400 human WASP 7454 P42768 WAS human S484 449295 RSRAIHssDEGEDQA X X +CSNK2A1 CK2A1 P68400 human Sialoprotein-2 281233 Q28862 IBSP cow S98 8165300 NNGGNEDsDENEDEE BSP_II X +CSNK2A1 CK2A1 P68400 human BRCA1 672 P38398 BRCA1 human S1572 465559 ESGISLFsDDPEsDP X +CSNK2A1 CK2A1 P68400 human CCNH 902 P51946 CCNH human T315 455993 KHEEEEWtDDDLVEs X +CSNK2A1 CK2A1 P68400 human CTCF 396274 Q08705 CTCF chicken S609 448303 MRsKKEDssDsEENA X +CSNK2A1 CK2A1 P68400 human HMGA2 15364 P52927 Hmga2 mouse S104 469758 EEtssQEsAEED___ X +CSNK2A1 CK2A1 P68400 human RIGI 23586 O95786 RIGI human S855 17484201 PKPkQFssFEkRAKI RIG-I_C-RD X X +CSNK2A1 CK2A1 P68400 human HHEX 3087 Q03014 HHEX human S177 7430501 LAKMLQLsERQVKTW Homeodomain X +CSNK2A1 CK2A1 P68400 human EIF5 1983 P55010 EIF5 human S390 448030 KEAEEEssGGEEEDE W2 X X +CSNK2A1 CK2A1 P68400 human NCL 25135 P13383 Ncl rat S187 466006 AAPAAPAsEDEDEED X +CSNK2A1 CK2A1 P68400 human DNMT3A 13435 O88508 Dnmt3a mouse S386 17548178 LFPACHDsDEsDSGK X +CSNK2A1 CK2A1 P68400 human SRF 6722 P11831 SRF human S85 451801 GsEGDsEsGEEEELG X +CSNK2A1 CK2A1 P68400 human GAP43 14432 P06837 Gap43 mouse T89 449600 EGDGsAttDAAPAts Neuromodulin X +CSNK2A1 CK2A1 P68400 human PGRMC1 10857 O00264 PGRMC1 human S181 452525 GEEPtVysDEEEPkD X +CSNK2A1 CK2A1 P68400 human RRAD 6236 P55042 RRAD human S214 457394 LVRSREVsVDEGRAC Ras X +CSNK2A1 CK2A1 P68400 human DLG3 iso2 1741 Q92796-2 DLG3 human S295 4710993 QGVTSNtsDSESSSK X X +CSNK2A1 CK2A1 P68400 human CDC34 997 P49427 CDC34 human S222 448688 EVEEEADsCFGDDED X X +CSNK2A1 CK2A1 P68400 human DNMT3A 1788 Q9Y6K1 DNMT3A human S390 17548178 LFPVCHDsDEsDTAK X X +CSNK2A1 CK2A1 P68400 human TUBB3 10381 Q13509 TUBB3 human S444 451154 YEDDEEEsEAQGPK_ X +CSNK2A1 CK2A1 P68400 human IHPK2 51447 Q9UHH9 IP6K2 human S347 478422 RPEVVLDsDAEDLED IPK X +CSNK2A1 CK2A1 P68400 human ABCF1 23 Q8NE71 ABCF1 human S109 453457 KKLsVPtsDEEDEVP X +CSNK2A1 CK2A1 P68400 human DDIT3 1649 P35638 DDIT3 human S30 455503 EDLQEVLssDENGGT X +CSNK2A1 CK2A1 P68400 human NFkB-p65 5970 Q04206 RELA human S529 447799 GLPNGLLsGDEDFSs X X 71254; 96874; 78764 +CSNK2A1 CK2A1 P68400 human JNK2 5601 P45984 MAPK9 human T404 447650 SSMSTEQtLAsDTDS X +CSNK2A1 CK2A1 P68400 human SGT1 11319 O95905 ECD human S503 3178821 LGPRPNEsDsDDLDD SGT1 X +CSNK2A1 CK2A1 P68400 human DHFR 1719 P00374 DHFR human S145 25735921 RIMQDFEsDTFFPEI DHFR_1 X +CSNK2A1 CK2A1 P68400 human POLR2F 83503 O88828 Polr2f rat S2 465588 ______MsDNEDNFD X +CSNK2A1 CK2A1 P68400 human ANP32A 8125 P39687 ANP32A human S158 459186 DDKEAPDsDAEGyVE LRR_9 X +CSNK2A1 CK2A1 P68400 human SRPK1 6732 Q96SB4 SRPK1 human S51 456012 QEEEILGsDDDEQED X +CSNK2A1 CK2A1 P68400 human MUSK 18198 Q61006 Musk mouse S697 26367602 SPGPPPLsCAEQLCI PK_Tyr_Ser-Thr X +CSNK2A1 CK2A1 P68400 human HSP90A 3320 P07900 HSP90AA1 human S726 3180213 LEGDDDtsRMEEVD_ X +CSNK2A1 CK2A1 P68400 human ABCB1B 18669 P06795 Abcb1b mouse S669 22634901 IRRsIYRsVHRKQDQ X +CSNK2A1 CK2A1 P68400 human eIF2B-epsilon 100009393 P47823 EIF2B5 rabbit S718 449908 KEAEEEssEDD____ W2 X X +CSNK2A1 CK2A1 P68400 human Notch 1 4851 P46531 NOTCH1 human S1900 20831302 GGLEtGNsEEEEDAP Ank_2 X X +CSNK2A1 CK2A1 P68400 human MDC1 9656 Q14676 MDC1 human T378 477989 EsQAGsDtDVEEGKA X +CSNK2A1 CK2A1 P68400 human Calmodulin 801 P0DP23 CALM3 human S82 448705 RkMkDtDsEEEIrEA X X +CSNK2A1 CK2A1 P68400 human Caldesmon 373965 P12957 CALD1 chicken S26 457417 RLEAERLsyQRNDDD X +CSNK2A1 CK2A1 P68400 human AATF 26574 Q9NY61 AATF human S320 460426 NAGsEEIssEDDELV AATF-Che1 X X +CSNK2A1 CK2A1 P68400 human GADD45GIP1 90480 Q8TAE8 GADD45GIP1 human S221 474542 PAASGAPss______ X +CSNK2A1 CK2A1 P68400 human DDIT3 1649 P35638 DDIT3 human S14 455501 PFSFGTLssWELEAW X +CSNK2A1 CK2A1 P68400 human STX1A 116470 P32851 Stx1a rat S14 451261 ELRTAKDsDDDDDVt X +CSNK2A1 CK2A1 P68400 human MCM2 4171 P49736 MCM2 human S13 473057 EsFtMAssPAQRRRG X +CSNK2A1 CK2A1 P68400 human p53 7157 P04637 TP53 human S46 447536 AMDDLMLsPDDIEQW TAD2 X 2521 +CSNK2A1 CK2A1 P68400 human IGF2R 3482 P11717 IGF2R human S2484 451244 LVsFHDDsDEDLLHI X X +CSNK2A1 CK2A1 P68400 human XPB 2071 P19447 ERCC3 human S751 454425 FGTMSSMsGADDTVy X +CSNK2A1 CK2A1 P68400 human FGF14 2259 Q92915 FGF14 human S230 54201600 VTPsKsTsASAIMNG X +CSNK2A1 CK2A1 P68400 human IFI16 3428 Q16666 IFI16 human S132 450085 GAQkRKKsTKEKAGP X +CSNK2A1 CK2A1 P68400 human Ikaros 22778 Q03267 Ikzf1 mouse S293 15404028 LSDMPYDsANYEKED X +CSNK2A1 CK2A1 P68400 human CREB iso1 81646 P15337-1 Creb1 rat S129 450092 QKRREILsRRPsYRk pKID X +CSNK2A1 CK2A1 P68400 human PDIA6 10130 Q15084 PDIA6 human S22 465562 LAVNGLYsSSDDVIE X +CSNK2A1 CK2A1 P68400 human HMGN1 3150 P05114 HMGN1 human S8 465531 MPkRkVssAEGAAkE HMG14_17 X +CSNK2A1 CK2A1 P68400 human ER-alpha 2099 P03372 ESR1 human S167 448102 GGRERLAsTNDkGSM Oest_recep X 64508; 42101 +CSNK2A1 CK2A1 P68400 human C1R 715 P00736 C1R human S206 451385 TEASGYIsSLEYPRS CUB X +CSNK2A1 CK2A1 P68400 human Akt2 208 P31751 AKT2 human S131 33402214 CGsPsDSsTTEEMEV X +CSNK2A1 CK2A1 P68400 human LEF-1 51176 Q9UJU2 LEF1 human S61 471385 kSSLVNEsEIIPASN CTNNB1_binding X +CSNK2A1 CK2A1 P68400 human NPM1 4869 P06748 NPM1 human S125 459897 AVEEDAEsEDEEEED X +CSNK2A1 CK2A1 P68400 human AATF 26574 Q9NY61 AATF human S321 460427 AGsEEIssEDDELVE AATF-Che1 X X +CSNK2A1 CK2A1 P68400 human STI1 20867 Q60864 Stip1 mouse S189 465575 LLGVDLGsMDEEEEA X +CSNK2A1 CK2A1 P68400 human Restin 6249 P30622 CLIP1 human S1364 3189736 DDLNNYDsDDQEKQS X X +CSNK2A1 CK2A1 P68400 human PEA-15 18611 Q62048 Pea15 mouse S116 450281 KDIIRQPsEEEIIKL X +CSNK2A1 CK2A1 P68400 human CFTR 1080 P13569 CFTR human S427 1382554801 ktsNGDDsLFFSNFS X +CSNK2A1 CK2A1 P68400 human DOK7 231134 Q18PE0 Dok7 mouse S346 41621603 GIATGSHssYSGSFS X +CSNK2A1 CK2A1 P68400 human ATF-1 466 P18846 ATF1 human S41 15725600 SLsESEEsQDSSDsI X +CSNK2A1 CK2A1 P68400 human p53 7157 P04637 TP53 human S6 447537 __MEEPQsDPsVEPP P53_TAD X 9285 +CSNK2A1 CK2A1 P68400 human AQP4 25293 P47863 Aqp4 rat S315 465557 DEKKGKDssGEVLss X +CSNK2A1 CK2A1 P68400 human eIF2-beta 8894 P20042 EIF2S2 human S2 451805 ______MsGDEMIFD X X +CSNK2A1 CK2A1 P68400 human CREB iso1 81646 P15337-1 Creb1 rat S143 448548 kILNDLssDAPGVPR pKID X +CSNK2A1 CK2A1 P68400 human CDH1 12550 P09803 Cdh1 mouse S855 465567 ssLNSsEsDQDQDYD CADH_Y-type_LIR X +CSNK2A1 CK2A1 P68400 human NFL 18039 P08551 Nefl mouse S473 450895 EAKDEPPsEGEAEEE X +CSNK2A1 CK2A1 P68400 human HSP90A 3320 P07900 HSP90AA1 human T725 3180216 PLEGDDDtsRMEEVD X +CSNK2A1 CK2A1 P68400 human SLC29A1 2030 Q99808 SLC29A1 human S254 486282 EtkLDLIskGEEPRA Nucleoside_tran X +CSNK2A1 CK2A1 P68400 human ECE1 iso3 1889 P42892-3 ECE1 human T9 14159846 MStYkRAtLDEEDLV X +CSNK2A1 CK2A1 P68400 human HSP90A 3320 P07900 HSP90AA1 human T36 15410982 LMSLIINtFySNkEI X X +CSNK2A1 CK2A1 P68400 human SPTAN1 20740 P16546 Sptan1 mouse S1302 14828401 TAQRLIQsHPEsAED Spectrin X +CSNK2A1 CK2A1 P68400 human NHE5 6553 Q14940 SLC9A5 human S702 20832300 AVILTVEsEEEEEEs X +CSNK2A1 CK2A1 P68400 human UBC3B 54926 Q712K3 UBE2R2 human S233 449751 DCYDDDDsGNEEs__ X X +CSNK2A1 CK2A1 P68400 human CDC34 997 P49427 CDC34 human T233 448689 DDEDDsGtEEs____ X X +CSNK2A1 CK2A1 P68400 human p53 7157 P04637 TP53 human T150 456327 VQLWVDstPPPGtRV P53 X +CSNK2A1 CK2A1 P68400 human 4E-BP1 116636 Q62622 Eif4ebp1 rat S64 447527 FLMECRNsPVAKtPP eIF_4EBP X 9451; 9456 +CSNK2A1 CK2A1 P68400 human PSEN2 5664 P49810 PSEN2 human S330 448567 MEEDsYDsFGEPsYP Presenilin; Presenilin X +CSNK2A1 CK2A1 P68400 human EEF1D 1936 P29692 EEF1D human S162 457574 DDIDLFGsDNEEEDk EF-1_beta_acid X X +CSNK2A1 CK2A1 P68400 human CD6 923 P30203 CD6 human S484 28095002 DSDsGsDsDYEHYDF X +CSNK2A1 CK2A1 P68400 human amphiphysin 273 P49418 AMPH human T387 469997 LPWDLWTtSTDLVQP X X +CSNK2A1 CK2A1 P68400 human ABCC1 4363 P33527 ABCC1 human T249 25592000 WSLNkEDtSEQVVPV X X +CSNK2A1 CK2A1 P68400 human CFTR 1080 P13569 CFTR human S511 477193 ENIIFGVsyDEyRYR ABC_tran X X +CSNK2A1 CK2A1 P68400 human ABCA1 19 O95477 ABCA1 human S1255 452019 FLKVAEEsGVDAETs X +CSNK2A1 CK2A1 P68400 human EIF5 1983 P55010 EIF5 human T208 3339004 DDWGEDttEEAQRRR X +CSNK2A1 CK2A1 P68400 human Jun 3725 P05412 JUN human T231 455366 ALkEEPQtVPEMPGE Jun X X +CSNK2A1 CK2A1 P68400 human PSEN2 5664 P49810 PSEN2 human S7 449960 _MLTFMAsDsEEEVC X +CSNK2A1 CK2A1 P68400 human FURIN 5045 P09958 FURIN human S775 469743 QEECPsDsEEDEGRG X +CSNK2A1 CK2A1 P68400 human SIRT1 93759 Q923E4 Sirt1 mouse S649 6855923 FHGAEVYsDsEDDVL X X +CSNK2A1 CK2A1 P68400 human IGFBP3 3486 P17936 IGFBP3 human S140 451463 APGNAsEsEEDRsAG X X +CSNK2A1 CK2A1 P68400 human CETN2 1069 P41208 CETN2 human T138 471512 kELGENLtDEELQEM EF-hand_7 X +CSNK2A1 CK2A1 P68400 human CALU iso15 813 O43852-15 CALU human T73 29606705 MYSHDGNtDEPEWVK X +CSNK2A1 CK2A1 P68400 human HMGN1 614915 P02316 HMGN1 cow S100 451698 AEEKEAKsD______ X +CSNK2A1 CK2A1 P68400 human DDIT3 1649 P35638 DDIT3 human S15 455502 FSFGTLssWELEAWY X +CSNK2A1 CK2A1 P68400 human DZIP1 66573 Q8BMD2 Dzip1 mouse S706 21241901 FGKSAVKsDTDWTEG X X +CSNK2A1 CK2A1 P68400 human ERK2 5594 P28482 MAPK1 human S246 6845001 HILGILGsPsQEDLN Pkinase X X +CSNK2A1 CK2A1 P68400 human XRCC1 7515 P18887 XRCC1 human S410 3181465 MAGPGsssEEDEAsH X +CSNK2A1 CK2A1 P68400 human NCL 17975 P09405 Ncl mouse S34 466005 DsEDEEMsEDEDDss X +CSNK2A1 CK2A1 P68400 human S100B 525716 P02638 S100B cow S63 465589 KVMETLDsDGDGECD EF-hand_1 X +CSNK2A1 CK2A1 P68400 human Myc 4609 P01106 MYC human S267 466014 PPTtssDsEEEQEDE Myc_N X +CSNK2A1 CK2A1 P68400 human MDC1 9656 Q14676 MDC1 human T404 3196400 sMVINsDtDDEEEVs X +CSNK2A1 CK2A1 P68400 human PPP1R2P3 153743 Q6NXS1 PPP1R2B human S121 27842901 yRIQEQEssGEEDsD IPP-2 X +CSNK2A1 CK2A1 P68400 human amphiphysin 273 P49418 AMPH human T350 469996 PEVKKEEtLLDLDFD X X +CSNK2A1 CK2A1 P68400 human MDC1 9656 Q14676 MDC1 human T331 477988 FGFIDsDtDAEEERI X +CSNK2A1 CK2A1 P68400 human Nur77 3164 P22736 NR4A1 human S152 25692904 SFQPPQLsPWDGSFG X X +CSNK2A1 CK2A1 P68400 human RNF7 9616 Q9UBF6 RNF7 human T10 449925 DVEDGEEtCALAsHS X X +CSNK2A1 CK2A1 P68400 human CREM 12916 P27699 Crem mouse T110 450058 QVATIAEtDDsADsE X +CSNK2A1 CK2A1 P68400 human HMGN1 3150 P05114 HMGN1 human S86 451696 GEtktEEsPAsDEAG HMG14_17 X +CSNK2A1 CK2A1 P68400 human PPP1R2P3 153743 Q6NXS1 PPP1R2B human S127 27842902 EssGEEDsDLsPEER IPP-2 X +CSNK2A1 CK2A1 P68400 human PD-L1 29126 Q9NZQ7 CD274 human T285 1876861204 NsKkQsDtHLEEt__ X X +CSNK2A1 CK2A1 P68400 human RAP80 51720 Q96RL1 UIMC1 human S44 470700 EDAFIVIsDsDGEEP X +CSNK2A1 CK2A1 P68400 human SIRT1 93759 Q923E4 Sirt1 mouse S154 6006902 NGFHsCEsDDDDRTS X X +CSNK2A1 CK2A1 P68400 human XPC 7508 Q01831 XPC human S94 3194024 VIKDEALsDGDDLRD X +CSNK2A1 CK2A1 P68400 human XRCC1 7515 P18887 XRCC1 human T523 451448 AGstDENtDsEEHQE X X +CSNK2A1 CK2A1 P68400 human Bcr 110279 Q6PAJ1 Bcr mouse Y178 447792 ADAEKPFyVNVEFHH X 3901 +CSNK2A1 CK2A1 P68400 human SIRT1 93759 Q923E4 Sirt1 mouse S651 6855924 GAEVYsDsEDDVLSS X X +CSNK2A1 CK2A1 P68400 human CREB iso1 81646 P15337-1 Creb1 rat S114 451809 EsEDsQEsVDsVtDs pKID X +CSNK2A1 CK2A1 P68400 human PPP1R2 5504 P41236 PPP1R2 human S122 449053 RIQEQEssGEEDsDL IPP-2 X +CSNK2A1 CK2A1 P68400 human DTD1 92675 Q8TEA8 DTD1 human S196 476434 RKEDRsAssGAEGDV X +CSNK2A1 CK2A1 P68400 human C/EBP-delta 1052 P49716 CEBPD human S57 40263800 PAMYDDEsAIDFSAY X X +CSNK2A1 CK2A1 P68400 human DZIP1 66573 Q8BMD2 Dzip1 mouse S665 13907506 TKTPPFssEEEPDEE X X +CSNK2A1 CK2A1 P68400 human TFPI 7035 P10646 TFPI human S30 451319 PAPLNADsEEDEEHT X +CSNK2A1 CK2A1 P68400 human FNIP1 96459 Q8TF40 FNIP1 human S946 4734332 sDsALGDsEsEDTGH X +CSNK2A1 CK2A1 P68400 human CDH1 999 P12830 CDH1 human S853 465567 SsLNsSEsDKDQDYD CADH_Y-type_LIR X +CSNK2A1 CK2A1 P68400 human PPAR-gamma iso2 19016 P37238-2 Pparg mouse S16 12170300 WPTNFGIsSVDLsVM PPARgamma_N X +CSNK2A1 CK2A1 P68400 human MYH10 4628 P35580 MYH10 human T1960 465601 LELsDDDtEsKtsDV X +CSNK2A1 CK2A1 P68400 human LASS4 79603 Q9HA82 CERS4 human S349 7102761 sDVEEsDssEEAAAA X +CSNK2A1 CK2A1 P68400 human IGF2R 3482 P11717 IGF2R human S2409 451243 LHGDDQDsEDEVLtI X X +CSNK2A1 CK2A1 P68400 human XRCC1 7515 P18887 XRCC1 human S518 451449 GEDPyAGstDENtDs X X +CSNK2A1 CK2A1 P68400 human PTEN 5728 P60484 PTEN human S385 448650 RYsDttDsDPENEPF X +CSNK2A1 CK2A1 P68400 human calsequestrin 2 845 O14958 CASQ2 human S393 1868253003 DEEDNDDsDDDDDE_ X +CSNK2A1 CK2A1 P68400 human CDH1 12550 P09803 Cdh1 mouse S853 465566 sLssLNSsEsDQDQD CADH_Y-type_LIR X +CSNK2A1 CK2A1 P68400 human GYS1 100008660 P13834 GYS1 rabbit S657 449790 RHSsPHQsEDEEEPR Glycogen_syn X +CSNK2A1 CK2A1 P68400 human IkB-alpha 4792 P25963 NFKBIA human S293 451525 EEsyDtEsEFTEFtE X X +CSNK2A1 CK2A1 P68400 human MDC1 9656 Q14676 MDC1 human T455 453677 ttERDsDtDVEEEEL X +CSNK2A1 CK2A1 P68400 human WAVE2 10163 Q9Y6W5 WASF2 human S484 6377638 IAVEYsDsEDDssEF X +CSNK2A1 CK2A1 P68400 human TWIST1 7291 Q15672 TWIST1 human S20 18899300 ADDSLsNsEEEPDRQ X X +CSNK2A1 CK2A1 P68400 human MDC1 9656 Q14676 MDC1 human S453 453670 QtttERDsDtDVEEE X +CSNK2A1 CK2A1 P68400 human p47phox 653361 P14598 NCF1 human S283 465579 PSMyLQKsGQDVsQA NECFESHC X +CSNK2A1 CK2A1 P68400 human MYH9 4627 P35579 MYH9 human S1943 456730 RKGAGDGsDEEVDGK X X 5026; 14611 +CSNK2A1 CK2A1 P68400 human STX1A 6804 Q16623 STX1A human S14 451261 ELRTAKDsDDDDDVA X X +CSNK2A1 CK2A1 P68400 human Calmodulin 24242 P0DP29 Calm3 rat S82 448705 RKMkDtDsEEEIREA X X +CSNK2A1 CK2A1 P68400 human RAD9A 5883 Q99638 RAD9A human S341 449817 PKsPGPHsEEEDEAE X +CSNK2A1 CK2A1 P68400 human HES6 55502 Q96HZ4 HES6 human S183 455670 GPGDDLCsDLEEAPE X +CSNK2A1 CK2A1 P68400 human p27Kip1 1027 P46527 CDKN1B human S83 451426 WQEVEkGsLPEFyyR X +CSNK2A1 CK2A1 P68400 human AATF 26574 Q9NY61 AATF human S155 3214059 GFsVQsIsDFEkFTK X +CSNK2A1 CK2A1 P68400 human coronin 1C 23603 Q9ULV4 CORO1C human S463 22996300 CNQDERIskLEQQMA X X +CSNK2A1 CK2A1 P68400 human SEC63 11231 Q9UGP8 SEC63 human S748 3215004 DsEGFEDsFEEEEEE X X +CSNK2A1 CK2A1 P68400 human HMGN1 3150 P05114 HMGN1 human S7 447788 _MPkRkVssAEGAAk HMG14_17 X +CSNK2A1 CK2A1 P68400 human ERK2 5594 P28482 MAPK1 human S248 6845000 LGILGsPsQEDLNCI Pkinase X X +CSNK2A1 CK2A1 P68400 human ANP32B 10541 Q92688 ANP32B human T244 456786 GEkRKREtDDEGEDD X X +CSNK2A1 CK2A1 P68400 human PSMA3 29670 P18422 Psma3 rat S250 451185 sLKEEDEsDDDNM__ X +CSNK2A1 CK2A1 P68400 human GAP43 14432 P06837 Gap43 mouse T95 449601 ttDAAPAtsPkAEEP Neuromodulin X +CSNK2A1 CK2A1 P68400 human NIPP-1 282319 Q28147 PPP1R8 cow S204 451338 KNsRVTFsEDDEIIN X +CSNK2A1 CK2A1 P68400 human EEF1D 100009222 P53787 EEF1D rabbit S162 457574 DDIDLFGsDEEEDKE EF-1_beta_acid X +CSNK2A1 CK2A1 P68400 human IGFBP3 3486 P17936 IGFBP3 human S138 451462 PPAPGNAsEsEEDRs X X +CSNK2A1 CK2A1 P68400 human DOK7 231134 Q18PE0 Dok7 mouse S273 41621607 sSSEASHsDISASSR X +CSNK2A1 CK2A1 P68400 human VHL 7428 P40337 VHL human S43 15573202 EEsGPEEsGPEELGA X +CSNK2A1 CK2A1 P68400 human SCN2A 24766 P04775 Scn2a rat S1112 6003508 VPIALGEsDFENLNT Na_trans_assoc X +CSNK2A1 CK2A1 P68400 human Sialoprotein-2 281233 Q28862 IBSP cow S64 457539 RFAVQsSsDssEENG BSP_II X +CSNK2A1 CK2A1 P68400 human PD-L1 29126 Q9NZQ7 CD274 human T290 56667601 sDtHLEEt_______ X X +CSNK2A1 CK2A1 P68400 human CDC34 997 P49427 CDC34 human S231 448654 FGDDEDDsGtEEs__ X X +CSNK2A1 CK2A1 P68400 human PIP4K2A 5305 P48426 PIP4K2A human S304 450664 DGEEEGEsDGTHPVG PIP5K X X +CSNK2A1 CK2A1 P68400 human A-Myb 4603 P10243 MYBL1 human S7 465555 _MAKRSRsEDEDDDL X +CSNK2A1 CK2A1 P68400 human DHFR 1719 P00374 DHFR human S168 55369311 PEYPGVLsDVQEEkG DHFR_1 X +CSNK2A1 CK2A1 P68400 human EXOSC9 5393 Q06265 EXOSC9 human S394 3194468 APIILsDsEEEEMII X X +CSNK2A1 CK2A1 P68400 human AATF 26574 Q9NY61 AATF human S288 25279151 ALKALLRsLVGLQEE AATF-Che1 X +CSNK2A1 CK2A1 P68400 human DPF3 iso2 8110 Q92784-2 DPF3 human S348 23251120 GRRsGRGsPtADKKG X X +CSNK2A1 CK2A1 P68400 human MAZ 4150 P56270 MAZ human S460 465574 PTAVGSLsGAEGVPV X X +CSNK2A1 CK2A1 P68400 human MEF2A 4205 Q02078 MEF2A human S289 456758 KGMMPPLsEEEELEL X +CSNK2A1 CK2A1 P68400 human TWIST1 7291 Q15672 TWIST1 human S18 18899301 SPADDSLsNsEEEPD X X +CSNK2A1 CK2A1 P68400 human CTCF 396274 Q08705 CTCF chicken S612 448305 KKEDssDsEENAEPD X X +CSNK2A1 CK2A1 P68400 human PDIA6 10130 Q15084 PDIA6 human S428 452832 VEDDIDLsDVELDDL X +CSNK2A1 CK2A1 P68400 human RPAP3 79657 Q9H6T3 RPAP3 human S119 1279822 HEsLsQEsEsEEdGI X X +CSNK2A1 CK2A1 P68400 human Calmodulin 801 P0DP23 CALM3 human T80 448704 MARkMkDtDsEEEIr X X +CSNK2A1 CK2A1 P68400 human CPLX2 281711 P84088 CPLX2 cow S115 474556 EEEEEEEsILDTVLK Synaphin X +CSNK2A1 CK2A1 P68400 human NCAPG 64151 Q9BPX3 NCAPG human S975 3210612 tAEADsEsDHEVPEP X +CSNK2A1 CK2A1 P68400 human Myc 4609 P01106 MYC human S264 466012 EEtPPTtssDsEEEQ Myc_N X +CSNK2A1 CK2A1 P68400 human FGF14 2259 Q92915 FGF14 human S228 54201601 PGVTPsKsTsASAIM X +CSNK2A1 CK2A1 P68400 human RIC8A 293614 Q80ZG1 Ric8a rat S522 3213321 ETMEGQLssDPDsDP X +CSNK2A1 CK2A1 P68400 human RAD51 5888 Q06609 RAD51 human T13 23305002 QLEANADtsVEEESF X +CSNK2A1 CK2A1 P68400 human NFkB-p65 309165 Q7TQN4 Rela rat S528 447799 SGLPNGLsGDEDFSs X +CSNK2A1 CK2A1 P68400 human ATF-1 466 P18846 ATF1 human S50 15725603 DSSDsIGssQKAHGI pKID X +CSNK2A1 CK2A1 P68400 human PACS2 23241 Q86VP3 PACS2 human S213 1884003504 FssEQEAsDDAVQGQ X X +CSNK2A1 CK2A1 P68400 human NHE5 6553 Q14940 SLC9A5 human S711 20832303 EEEEEsDssEtEKED X +CSNK2A1 CK2A1 P68400 human CHD-4 1108 Q14839 CHD4 human S310 471449 skRKRsssEDDDLDV X +CSNK2A1 CK2A1 P68400 human DTD1 92675 Q8TEA8 DTD1 human T187 36396302 EssKERNtPRKEDRs X +CSNK2A1 CK2A1 P68400 human GAP43 14432 P06837 Gap43 mouse T88 449599 kEGDGsAttDAAPAt Neuromodulin X +CSNK2A1 CK2A1 P68400 human XRCC1 7515 P18887 XRCC1 human S409 3181462 LMAGPGsssEEDEAs X +CSNK2A1 CK2A1 P68400 human NASP iso2 4678 P49321-2 NASP human S158 476187 tEEMPNDsVLENKSL X X +CSNK2A1 CK2A1 P68400 human PAX3 5077 P23760 PAX3 human S205 4145506 APQsDEGsDIDsEPD X +CSNK2A1 CK2A1 P68400 human XRCC1 7515 P18887 XRCC1 human T519 451450 EDPyAGstDENtDsE X X +CSNK2A1 CK2A1 P68400 human Ikaros 22778 Q03267 Ikzf1 mouse S101 4828301 GSHRDQGsSALSGVG X +CSNK2A1 CK2A1 P68400 human calpastatin 831 P20810 CAST human S655 25733148 QDPIDALsGDLDsCP X +CSNK2A1 CK2A1 P68400 human HS1 3059 P14317 HCLS1 human T16 11349500 DVSVsVEtQGDDWDt X +CSNK2A1 CK2A1 P68400 human IkB-beta 4793 Q15653 NFKBIB human S313 452013 EKsGPCSsSsDSDSG X +CSNK2A1 CK2A1 P68400 human SIRT1 23411 Q96EB6 SIRT1 human S659 6855923 FHGAEVYsDsEDDVL X X +CSNK2A1 CK2A1 P68400 human M6PR 17113 P24668 M6pr mouse S268 455293 DDQLGEEsEERDDHL Man-6-P_recep X +CSNK2A1 CK2A1 P68400 human TNFAIP1 7126 Q13829 TNFAIP1 human S278 460382 SRSRSQAsPsEDEEt X +CSNK2A1 CK2A1 P68400 human VHL 7428 P40337 VHL human S33 15573201 EEDGGEEsGAEEsGP X +CSNK2A1 CK2A1 P68400 human ARL13B 68146 Q640N2 Arl13b mouse S328 4732982 ALsQQLDsEDEQDQR X +CSNK2A1 CK2A1 P68400 human TDP-43 23435 Q13148 TARDBP human S409 3084616 GssMDskssGWGM__ X +CSNK2A1 CK2A1 P68400 human PhLP 5082 Q13371 PDCL human S19 448824 KLQYyysssEDEDsD X X +CSNK2A1 CK2A1 P68400 human HMGA1 3159 P17096 HMGA1 human S103 452255 EGIsQEssEEEQ___ X +CSNK2A1 CK2A1 P68400 human RAD9A 5883 Q99638 RAD9A human S387 449815 sPVLAEDsEGEG___ X +CSNK2A1 CK2A1 P68400 human AQP4 25293 P47863 Aqp4 rat S276 465556 AAQQTkGsYMEVEDN X +CSNK2A1 CK2A1 P68400 human EIF5 1983 P55010 EIF5 human S389 448029 LKEAEEEssGGEEED W2 X X +CSNK2A1 CK2A1 P68400 human ASCL1 17172 Q02067 Ascl1 mouse S150 453455 GAANKKMsKVETLRS HLH X X +CSNK2A1 CK2A1 P68400 human CTDP1 9150 Q9Y5B0 CTDP1 human T584 455468 EEEEEEDtDEDDHLI X +CSNK2A1 CK2A1 P68400 human GGA1 26088 Q9UJY5 GGA1 human S355 455525 EQPSASVsLLDDELM X +CSNK2A1 CK2A1 P68400 human PIAS1 8554 O75925 PIAS1 human S468 4700794 DLtIDsssDEEEEEP X X +CSNK2A1 CK2A1 P68400 human WAVE2 10163 Q9Y6W5 WASF2 human S488 6377641 YsDsEDDssEFDEDD X +CSNK2A1 CK2A1 P68400 human PDX1 18609 P52946 Pdx1 mouse S232 13421406 EQDCAVtsGEELLAV X X +CSNK2A1 CK2A1 P68400 human CTDP1 9150 Q9Y5B0 CTDP1 human S575 11276300 AGESLDQsMEEEEEE X +CSNK2A1 CK2A1 P68400 human NCL 17975 P09405 Ncl mouse S40 468243 MsEDEDDssGEEEVV X +CSNK2A1 CK2A1 P68400 human NCAM-L1 3897 P32004 L1CAM human T1172 4702537 ARPMkDEtFGEyRSL Bravo_FIGEY X +CSNK2A1 CK2A1 P68400 human XRCC4 7518 Q13426 XRCC4 human T233 2286405 DPVyDEstDEEsENQ XRCC4 X +CSNK2A1 CK2A1 P68400 human Myb 4602 P10242 MYB human S11 448186 RPRHSIYssDEDDED X +CSNK2A1 CK2A1 P68400 human ANP32A 8125 P39687 ANP32A human S204 459187 EGEEEDVsGEEEEDE X +CSNK2A1 CK2A1 P68400 human HDAC3 8841 O15379 HDAC3 human S424 455624 DHDNDKEsDVEI___ X X 3815 +CSNK2A1 CK2A1 P68400 human Sialoprotein-2 281233 Q28862 IBSP cow S154 457545 KATKEDEsDEEEEEE BSP_II X +CSNK2A1 CK2A1 P68400 human CDC37 11140 Q16543 CDC37 human S13 450034 VWDHIEVsDDEDETH CDC37_N X 13248 +CSNK2A1 CK2A1 P68400 human MRE11A 4361 P49959 MRE11 human S561 23127159 MANDsDDsISAATNK X X +CSNK2A1 CK2A1 P68400 human HMGA2 15364 P52927 Hmga2 mouse T99 7493925 PAQETEEtssQEsAE X +CSNK2A1 CK2A1 P68400 human DOK7 231134 Q18PE0 Dok7 mouse S347 41621601 IATGSHssYSGSFSS X +CSNK2A1 CK2A1 P68400 human RRAD 6236 P55042 RRAD human S290 457397 GRIVARNsRKMAFRA X +CSNK2A1 CK2A1 P68400 human PhLP 5082 Q13371 PDCL human S18 448823 EKLQYyysssEDEDs X X +CSNK2A1 CK2A1 P68400 human SEPT2 4735 Q15019 SEPTIN2 human S218 459178 yHLPDAEsDEDEDFk Septin X X +CSNK2A1 CK2A1 P68400 human PGK1 5230 P00558 PGK1 human S256 23131090 NNMEIGTsLFDEEGA PGK X X +CSNK2A1 CK2A1 P68400 human MRTO4 51154 Q9UKD2 MRTO4 human S229 14576310 LPEsAsEsTEEsDsE X +CSNK2A1 CK2A1 P68400 human PPP1R2P3 153743 Q6NXS1 PPP1R2B human S122 27842900 RIQEQEssGEEDsDL IPP-2 X +CSNK2A1 CK2A1 P68400 human RAD17 5884 O75943 RAD17 human S678 1184590201 IIIEDyEsDGt____ X +CSNK2A1 CK2A1 P68400 human EXOSC9 5393 Q06265 EXOSC9 human S392 3194465 QDAPIILsDsEEEEM X X +CSNK2A1 CK2A1 P68400 human CDC25B 994 P30305 CDC25B human S187 448747 AGsGAAsssGEDkEN M-inducer_phosp X +CSNK2A1 CK2A1 P68400 human MAT1A 4143 Q00266 MAT1A human S114 27996470 LVALEQQsPDIAQCV S-AdoMet_synt_N X X +CSNK2A1 CK2A1 P68400 human COL17A1 1308 Q9UMD9 COL17A1 human S544 484007 KIGLHsDsQEELWMF X +CSNK2A1 CK2A1 P68400 human Sialoprotein-2 P13839 Ibsp rat S153 457545 KAPKMKEsDEEEEEE BSP_II X +CSNK2A1 CK2A1 P68400 human NPHP1 4867 O15259 NPHP1 human S121 26395106 PTEEEEEsEsEDsED X X +CSNK2A1 CK2A1 P68400 human LSD1 23028 O60341 KDM1A human S137 449181 LsEDEyysEEERNAK X X +CSNK2A1 CK2A1 P68400 human MAX 4149 P61244 MAX human S2 449307 ______MsDNDDIEV X +CSNK2A1 CK2A1 P68400 human RFC1 89809 D3ZFT1 Rfc1 rat S71 452681 RIIyDsDsESEETVQ X +CSNK2A1 CK2A1 P68400 human Ikaros 22778 Q03267 Ikzf1 mouse S388 451351 REAsPsNsCQDstDt X +CSNK2A1 CK2A1 P68400 human NMDAR2B 24410 Q00960 Grin2b rat S1480 454415 EKLssIEsDV_____ NMDAR2_C X X +CSNK2A1 CK2A1 P68400 human HSP90B 3326 P08238 HSP90AB1 human S226 454114 kEREKEIsDDEAEEE HSP90 X X +CSNK2A1 CK2A1 P68400 human STX1B 24923 P61265 Stx1b rat S14 450122 ELRSAKDsDDEEEVV X +CSNK2A1 CK2A1 P68400 human VTN 7448 P04004 VTN human T69 451403 VTRGDVFtMPEDEyt X +CSNK2A1 CK2A1 P68400 human C/EBP-beta 12608 P28033 Cebpb mouse S222 408589401 kktVDKLsDEYKMRR bZIP_2 X +CSNK2A1 CK2A1 P68400 human NHE5 6553 Q14940 SLC9A5 human S709 20832304 sEEEEEEsDssEtEK X +CSNK2A1 CK2A1 P68400 human ABCA1 19 O95477 ABCA1 human T1243 452018 SYGISEttLEEIFLK X +CSNK2A1 CK2A1 P68400 human PDX1 18609 P52946 Pdx1 mouse T231 13421407 PEQDCAVtsGEELLA X X +CSNK2A1 CK2A1 P68400 human SRC-2 10499 Q15596 NCOA2 human S493 468245 LsPrHRMsPGVAGsP NCOA_u2 X +CSNK2A1 CK2A1 P68400 human HOXB6 15414 P09023 Hoxb6 mouse S214 450896 LLSASQLsAEEEEEK X +CSNK2A1 CK2A1 P68400 human PML 5371 P29590 PML human S565 2479600 VIsssEDsDAENSSS DUF3583 X X +CSNK2A1 CK2A1 P68400 human XRCC1 7515 P18887 XRCC1 human Y515 40274401 EENGEDPyAGstDEN X +CSNK2A1 CK2A1 P68400 human eEF1B 100009286 P34826 EEF1B2 rabbit S112 465598 GsDDEEEsEEAKRLR EF-1_beta_acid X +CSNK2A1 CK2A1 P68400 human TOP2A 7153 P11388 TOP2A human S1469 452243 NRRKRkPstsDDsDs DTHCT X 13072 +CSNK2A1 CK2A1 P68400 human ABCB1B 18669 P06795 Abcb1b mouse S681 22634900 QDQERRLsMKEAVDE X +CSNK2A1 CK2A1 P68400 human IGFBP1 3484 P08833 IGFBP1 human S126 451658 GsPEsPEstEITEEE X X +CSNK2A1 CK2A1 P68400 human DOK7 231134 Q18PE0 Dok7 mouse S264 41621604 GGDDRSLsssSSEAS X +CSNK2A1 CK2A1 P68400 human EIF4G2 1982 P78344 EIF4G2 human S902 12738134 ETAEEEEsEEEAD__ W2 X +CSNK2A1 CK2A1 P68400 human HDAC2 3066 Q92769 HDAC2 human S394 449930 EDAVHEDsGDEDGED X X 61458; 69238 +CSNK2A1 CK2A1 P68400 human SLBP 7884 Q14493 SLBP human T61 466351 ERRPEsFttPEGPkP X +CSNK2A1 CK2A1 P68400 human SRF 6722 P11831 SRF human S79 451803 AGALYsGsEGDsEsG X +CSNK2A1 CK2A1 P68400 human NIPP-1 282319 Q28147 PPP1R8 cow T161 451339 LGLPEEEtELDNLTE X +CSNK2A1 CK2A1 P68400 human SEC63 11231 Q9UGP8 SEC63 human S574 27440601 EEVsDKGsDsEEEET X X +CSNK2A1 CK2A1 P68400 human N-CoR1 9611 O75376 NCOR1 human S2436 468249 SAQyEtLsDsDD___ X X +CSNK2A1 CK2A1 P68400 human SGT1 11319 O95905 ECD human S518 3178827 EDFECLDsDDDLDFE SGT1 X +CSNK2A1 CK2A1 P68400 human p53 7157 P04637 TP53 human T155 455908 DstPPPGtRVRAMAI P53 X +CSNK2A1 CK2A1 P68400 human p53 7157 P04637 TP53 human S392 447535 FktEGPDsD______ X 9281 +CSNK2A1 CK2A1 P68400 human CASP2 835 P42575 CASP2 human S157 456810 LykkLRLsTDtVEHs X X +CSNK2A1 CK2A1 P68400 human IkB-alpha 4792 P25963 NFKBIA human T291 451526 EDEEsyDtEsEFTEF X X +CSNK2A1 CK2A1 P68400 human CTCF 396274 Q08705 CTCF chicken S610 448304 RsKKEDssDsEENAE X +CSNK2A1 CK2A1 P68400 human FMR1 14265 P35922 Fmr1 mouse S499 469583 NSEAsNAsETESDHR FXMRP1_C_core X +CSNK2A1 CK2A1 P68400 human Myc 4609 P01106 MYC human S265 466013 EtPPTtssDsEEEQE Myc_N X +CSNK2A1 CK2A1 P68400 human CARD9 64170 Q9H257 CARD9 human T533 1206000 TGSDNtDtEGS____ X X +CSNK2A1 CK2A1 P68400 human RAP80 51720 Q96RL1 UIMC1 human S46 470701 AFIVIsDsDGEEPKE X +CSNK2A1 CK2A1 P68400 human RFC1 89809 D3ZFT1 Rfc1 rat T110 468618 PVTYIsEtDEDDDFL X +CSNK2A1 CK2A1 P68400 human MDC1 9656 Q14676 MDC1 human T301 477987 PPGEDsDtDVDDDsR X +CSNK2A1 CK2A1 P68400 human MDC1 9656 Q14676 MDC1 human S376 477758 LQEsQAGsDtDVEEG X +CSNK2A1 CK2A1 P68400 human CADPS 26989 Q62717 Cadps rat S1281 7712503 QGISMKDsDEEDEED X +CSNK2A1 CK2A1 P68400 human Snail1 6615 O95863 SNAI1 human S92 452602 VAELTsLsDEDsGkG X X +CSNK2A1 CK2A1 P68400 human GAP43 14432 P06837 Gap43 mouse S192 449597 PPTEtAEssQAEEEk Neuromodulin X +CSNK2A1 CK2A1 P68400 human Myf-5 4617 P13349 MYF5 human S133 457385 NAIRYIEsLQELLRE HLH X +CSNK2A1 CK2A1 P68400 human Sialoprotein-2 281233 Q28862 IBSP cow S66 457540 AVQsSsDssEENGNG BSP_II X +CSNK2A1 CK2A1 P68400 human LEF-1 51176 Q9UJU2 LEF1 human S42 471384 EkIFAEIsHPEEEGD CTNNB1_binding X +CSNK2A1 CK2A1 P68400 human MCM2 4171 P49736 MCM2 human S108 456310 DVEELtAsQREAAER MCM2_N X +CSNK2A1 CK2A1 P68400 human MUS81 80198 Q96NY9 MUS81 human S87 31880574 RLQRHRTsGGDHAPD X X +CSNK2A1 CK2A1 P68400 human CDH1 12550 P09803 Cdh1 mouse S842 15754600 FDYEGsGsEAAsLss CADH_Y-type_LIR X +CSNK2A1 CK2A1 P68400 human SRF 6722 P11831 SRF human S83 451800 YsGsEGDsEsGEEEE X +CSNK2A1 CK2A1 P68400 human ARC 85383 Q62881 Nol3 rat T149 448618 SEAVQPRtPEEPELE X +CSNK2A1 CK2A1 P68400 human SERINC3 10955 Q13530 SERINC3 human S380 1255792401 ILGDTTTsGAsDEED Serinc X X +CSNK2A1 CK2A1 P68400 human caveolin-2 858 P51636 CAV2 human S23 460671 DDsysHHsGLEyADP Caveolin X X +CSNK2A1 CK2A1 P68400 human H2AX 3014 P16104 H2AX human Y57 34492711 YLAAVLEyLTAEILE Histone X X +CSNK2A1 CK2A1 P68400 human PEDF 5176 P36955 SERPINF1 human S24 455231 SSCQNPAsPPEEGSP X +CSNK2A1 CK2A1 P68400 human DZIP1 66573 Q8BMD2 Dzip1 mouse S664 13907508 STKTPPFssEEEPDE X X +CSNK2A1 CK2A1 P68400 human DNMT3A 13435 O88508 Dnmt3a mouse S389 17548182 ACHDsDEsDSGKAVE X +CSNK2A1 CK2A1 P68400 human BRMS1 25855 Q9HCU9 BRMS1 human S30 25284673 MNGEEEEsEEERSGS X +CSNK2A1 CK2A1 P68400 human MYH10 4628 P35580 MYH10 human S1965 465602 DDtEsKtsDVNEtQP X +CSNK2A1 CK2A1 P68400 human N-Myc 4613 P04198 MYCN human S261 450052 TSGEDTLsDsDDEDD Myc_N X +CSNK2A1 CK2A1 P68400 human EVI1 2122 Q03112 MECOM human S1037 482637 IGNsNHGsQsPRNVE X X +CSNK2A1 CK2A1 P68400 human LASS4 79603 Q9HA82 CERS4 human S350 7102764 DVEEsDssEEAAAAQ X +CSNK2A1 CK2A1 P68400 human CREM 12916 P27699 Crem mouse S156 450064 PKIEEEKsEEEGTPP X +CSNK2A1 CK2A1 P68400 human SIRT6 51548 Q8N6T7 SIRT6 human S338 7916000 PKRERPtsPAPHRPP X +CSNK2A1 CK2A1 P68400 human WAVE2 10163 Q9Y6W5 WASF2 human S482 6377642 RRIAVEYsDsEDDss X +CSNK2A1 CK2A1 P68400 human NCL 17975 P09405 Ncl mouse S41 468244 sEDEDDssGEEEVVI X +CSNK2A1 CK2A1 P68400 human Sialoprotein-2 281233 Q28862 IBSP cow S62 467256 LKRFAVQsSsDssEE BSP_II X +CSNK2A1 CK2A1 P68400 human eIF2B-epsilon 100009393 P47823 EIF2B5 rabbit S717 449907 LKEAEEEssEDD___ W2 X X +CSNK2A1 CK2A1 P68400 human LASS4 79603 Q9HA82 CERS4 human S347 36704607 IRsDVEEsDssEEAA X +CSNK2A1 CK2A1 P68400 human Calmodulin 801 P0DP23 CALM3 human T118 469586 tNLGEkLtDEEVDEM EF-hand_7 X +CSNK2A1 CK2A1 P68400 human DOK7 231134 Q18PE0 Dok7 mouse S249 41621605 EKRLSLLsHSGRPGs X +CSNK2A1 CK2A1 P68400 human PAX3 18505 P24610 Pax3 mouse S205 4145506 APQsDEGsDIDsEPD X +CSNK2A1 CK2A1 P68400 human PhLP 64013 Q63737 Pdcl rat S18 448823 EKLQYYYstsEDEDs X +CSNK2A1 CK2A1 P68400 human RIOK1 83732 Q9BRS2 RIOK1 human T410 797986500 MEIASQRtkEERSSQ X X +CSNK2A1 CK2A1 P68400 human FNIP1 96459 Q8TF40 FNIP1 human S939 17550026 DIPRNEssDsALGDs X +CSNK2A1 CK2A1 P68400 human PER2 18627 O54943 Per2 mouse S697 468400 DMAsGPEsLDGAAGG X +CSNK2A1 CK2A1 P68400 human HMGA1 3159 P17096 HMGA1 human S102 452254 EEGIsQEssEEEQ__ X +CSNK2A1 CK2A1 P68400 human DTD1 92675 Q8TEA8 DTD1 human S205 485755 GAEGDVssErEP___ X +CSNK2A1 CK2A1 P68400 human PIN4 5303 Q9Y237 PIN4 human S19 3188102 AGKGGAAsGSDSADK X +CSNK2A1 CK2A1 P68400 human AATF 56321 Q9JKX4 Aatf mouse S316 1868281680 LEMEDyPsFMAkRFA AATF-Che1 X X +CSNK2A1 CK2A1 P68400 human CACNA1S 100009585 P07293 CACNA1S rabbit T1579 6061600 RTIsGDLtAEEELER X +CSNK2A1 CK2A1 P68400 human RPAP3 79657 Q9H6T3 RPAP3 human S116 472436 DstHEsLsQEsEsEE X X +CSNK2A1 CK2A1 P68400 human PhLP 64013 Q63737 Pdcl rat T19 448824 KLQYYYstsEDEDsD X +CSNK2A1 CK2A1 P68400 human SLC29A1 63959 Q9JIM1 Slc29a1 mouse S254 486282 ETkLDLIskGEEPKG Nucleoside_tran X +CSNK2A1 CK2A1 P68400 human EHMT2 10919 Q96KQ7 EHMT2 human S211 18009234 EIQHFRMsDDVHsLG X X +CSNK2A1 CK2A1 P68400 human 4E-BP1 1978 Q13541 EIF4EBP1 human S112 447526 KRAGGEEsQFEMDI_ eIF_4EBP X +CSNK2A1 CK2A1 P68400 human RANGAP1 5905 P46060 RANGAP1 human S358 458865 AKVLASLsDDEDEEE X X +CSNK2A1 CK2A1 P68400 human CD5 921 P06127 CD5 human S485 450128 QPDNssDsDyDLHGA X X +CSNK2A1 CK2A1 P68400 human eEF1B 100009286 P34826 EEF1B2 rabbit S106 452653 DDIDLFGsDDEEEsE EF-1_beta_acid X +CSNK2A1 CK2A1 P68400 human TNFAIP1 7126 Q13829 TNFAIP1 human S280 3195881 SRSQAsPsEDEEtFE X X +CSNK2A1 CK2A1 P68400 human SLC3A2 6520 P08195 SLC3A2 human S406 6003504 LLTssyLsDsGsTGE X +CSNK2A1 CK2A1 P68400 human RFC1 89809 D3ZFT1 Rfc1 rat S69 452680 KKRIIyDsDsESEET X +CSNK2A1 CK2A1 P68400 human CCNF 899 P41002 CCNF human S621 288031702 GYEGDQEsEGEKEGD X X +CSNK2A1 CK2A1 P68400 human ODC 24609 P09057 Odc1 rat S303 451283 VWKEQTGsDDEDESN Orn_DAP_Arg_deC X +CSNK2A1 CK2A1 P68400 human PACS2 23241 Q86VP3 PACS2 human S208 1884003502 EEYESFssEQEAsDD X X +CSNK2A1 CK2A1 P68400 human Sialoprotein-2 P13839 Ibsp rat S31 457538 RRIKAEDsEENGVFK BSP_II X +CSNK2A1 CK2A1 P68400 human ARNT 405 P27540 ARNT human S77 458309 DKERFARsDDEQssA X +CSNK2A1 CK2A1 P68400 human PTEN 5728 P60484 PTEN human S370 448649 TSVtPDVsDNEPDHy X X +CSNK2A1 CK2A1 P68400 human G6PD 2539 P11413 G6PD human T145 1883583400 FyLALPPtVyEAVTK X X +CSNK2A1 CK2A1 P68400 human adrenodoxin 281157 P00257 FDX1 cow T129 455475 FEKLEAItDEENDML Fer2 X +CSNK2A1 CK2A1 P68400 human FANCD2 2177 Q9BXW9 FANCD2 human S886 31867427 TSSsDtLsEEkNsEC FancD2 X X +CSNK2A1 CK2A1 P68400 human GJA8 395846 P36381 GJA8 chicken S364 465560 KAEEEVVsDEVEGPS X X +CSNK2A1 CK2A1 P68400 human NHE5 6553 Q14940 SLC9A5 human T714 20832302 EEsDssEtEKEDDEG X +CSNK2A1 CK2A1 P68400 human PhLP 5082 Q13371 PDCL human S20 448825 LQYyysssEDEDsDH X X +CSNK2A1 CK2A1 P68400 human PTEN 5728 P60484 PTEN human T383 448315 HyRYsDttDsDPENE X X 9554; 9549; 7960 +CSNK2A1 CK2A1 P68400 human TYMS 7298 P04818 TYMS human S124 13209303 FLDsLGFsTREEGDL Thymidylat_synt X +CSNK2A1 CK2A1 P68400 human CLTB 281698 P04975 CLTB cow S11 465605 DFGFFSSsEsGAPEA Clathrin_lg_ch X +CSNK2A1 CK2A1 P68400 human MRTO4 51154 Q9UKD2 MRTO4 human S233 14576313 AsEsTEEsDsEDDD_ X +CSNK2A1 CK2A1 P68400 human MCM2 4171 P49736 MCM2 human S40 452311 RRtDALtssPGRDLP X +CSNK2A1 CK2A1 P68400 human FTO 79068 Q9C0B1 FTO human T150 23108331 NDYLQIEtIQALEEL FTO_NTD X X +CSNK2A1 CK2A1 P68400 human RIC8A 293614 Q80ZG1 Ric8a rat S523 3213324 TMEGQLssDPDsDPD X +CSNK2A1 CK2A1 P68400 human DARPP-32 360616 Q6J4I0 Ppp1r1b rat S97 466340 LQTISNLsENQAsEE DARPP-32 X +CSNK2A1 CK2A1 P68400 human CD6 923 P30203 CD6 human S480 28095001 PPPEDSDsGsDsDYE X +CSNK2A1 CK2A1 P68400 human PSMD3 5709 O43242 PSMD3 human S6 18912808 __MkQEGsARRRGAD X +CSNK2A1 CK2A1 P68400 human Sialoprotein-2 P13839 Ibsp rat S76 457542 EENGDGDssEEEGEE BSP_II X +CSNK2A1 CK2A1 P68400 human CDH1 999 P12830 CDH1 human S847 465568 sEAAsLSsLNsSEsD CADH_Y-type_LIR X +CSNK2A1 CK2A1 P68400 human IRS1 25467 P35570 Irs1 rat S307 447558 TEsITATsPASMVGG X 2381 +CSNK2A1 CK2A1 P68400 human ABCA1 19 O95477 ABCA1 human T1242 452017 SSYGISEttLEEIFL X +CSNK2A1 CK2A1 P68400 human BIK 638 Q13323 BIK human T33 448350 TMEVLGMtDsEEDLD bcl-2I13 X +CSNK2A1 CK2A1 P68400 human PRPF3 9129 O43395 PRPF3 human T494 999610 TEAVQDPtKVEAHVR PRP3 X X +CSNK2A1 CK2A1 P68400 human STC2 8614 O76061 STC2 human S288 450097 AQGPSGssEWEDEQS X +CSNK2A1 CK2A1 P68400 human CETN2 1069 P41208 CETN2 human S158 34405001 RDGDGEVsEQEFLRI EF-hand_7 X +CSNK2A1 CK2A1 P68400 human RAD1 5810 O60671 RAD1 human S280 14881302 PDEEVPEsEs_____ X +CSNK2A1 CK2A1 P68400 human CREB3 10488 O43889 CREB3 human S46 1827354100 LPLSEVPsDWEVDDL X X +CSNK2A1 CK2A1 P68400 human NPM1 18148 Q61937 Npm1 mouse S125 459897 AVEEDAEsEDEDEED X +CSNK2A1 CK2A1 P68400 human TR-alpha iso5 21833 P63058_OBS Thra mouse S474 449309 ASSLSSSssDEDTEV X +CSNK2A1 CK2A1 P68400 human LASS6 253782 Q6ZMG9 CERS6 human S346 22350309 DRsDIEsssDEEDSE X +CSNK2A1 CK2A1 P68400 human CLTB 281698 P04975 CLTB cow S13 465606 GFFSSsEsGAPEAAE Clathrin_lg_ch X +CSNK2A1 CK2A1 P68400 human DDHD1 80821 Q8NEL9 DDHD1 human S104 465582 GSSLRYYsEGESGGG X +CSNK2A1 CK2A1 P68400 human KIR3DL1 3811 P43629 KIR3DL1 human S388 990303 RTANsEDsDEQDPEE X +CSNK2A1 CK2A1 P68400 human FGA 2243 P02671 FGA human S542 466009 PMLGEFVsETESRGs X +CSNK2A1 CK2A1 P68400 human N-Myc 4613 P04198 MYCN human S263 448221 GEDTLsDsDDEDDEE Myc_N X +CSNK2A1 CK2A1 P68400 human SGT1 11319 O95905 ECD human S505 3178824 PRPNEsDsDDLDDED SGT1 X +CSNK2A1 CK2A1 P68400 human TLE1 7088 Q04724 TLE1 human S253 23940705 DNLVVDVsNEDPSsP X +CSNK2A1 CK2A1 P68400 human FANCD2 2177 Q9BXW9 FANCD2 human S882 1871613600 DGSkTSSsDtLsEEk FancD2 X +CSNK2A1 CK2A1 P68400 human 14-3-3 gamma 22628 P61982 Ywhag mouse S235 14569218 DNLTLWTsDQQDDDG X +CSNK2A1 CK2A1 P68400 human RRAD 6236 P55042 RRAD human S299 457398 KMAFRAKsKsCHDLS X +CSNK2A1 CK2A1 P68400 human Huntingtin 3064 P42858 HTT human S16 12056100 kAFEsLksFQQQQQQ X +CSNK2A1 CK2A1 P68400 human p47phox 653361 P14598 NCF1 human S208 465580 KRGWIPAsFLEPLDS X +CSNK2A1 CK2A1 P68400 human DNAJB2 3300 P25686 DNAJB2 human S264 62382605 LAMAySLsEMEAAGK X +CSNK2A1 CK2A1 P68400 human COL17A1 1308 Q9UMD9 COL17A1 human S542 484006 LDKIGLHsDsQEELW X +CSNK2A1 CK2A1 P68400 human RIC8A 293614 Q80ZG1 Ric8a rat S527 3213327 QLssDPDsDPD____ X +CSNK2A1 CK2A1 P68400 human LSD1 23028 O60341 KDM1A human S131 453104 DEsLANLsEDEyysE X X 37177 +CSNK2A1 CK2A1 P68400 human Survivin 332 O15392 BIRC5 human T48 18451300 AGFIHCPtENEPDLA BIR X +CSNK2A1 CK2A1 P68400 human HMGA2 15364 P52927 Hmga2 mouse S100 4708612 AQETEEtssQEsAEE X +CSNK2A1 CK2A1 P68400 human G6PI 2821 P06744 GPI human S185 455279 GPRVWyVsNIDGTHI PGI X +CSNK2A1 CK2A1 P68400 human GCH1 2643 P30793 GCH1 human S81 487495 AYSSILSsLGENPQR GTP_cyclohydroI X +CSNK2A1 CK2A1 P68400 human MRE11A 4361 P49959 MRE11 human S649 455765 EVIEVDEsDVEEDIF X +CSNK2A1 CK2A1 P68400 human CLPH 64029 Q68FX6 Cabs1 rat T280 12658500 DNPEDPLtDEEPADG CABS1 X +CSNK2A1 CK2A1 P68400 human SRC-2 10499 Q15596 NCOA2 human S499 4728850 MsPGVAGsPrIPPSQ NCOA_u2 X +CSNK2A1 CK2A1 P68400 human FETUA 280988 P12763 AHSG cow S323 467424 SGVAsVEssSGEAFH X +CSNK2A1 CK2A1 P68400 human HDAC6 10013 Q9UBN7 HDAC6 human S458 18944908 EEDNVEEsEEEGPWE X +CSNK2A1 CK2A1 P68400 human CDC37 114562 Q63692 Cdc37 rat S13 450034 VWDHIEVsDDEDETH CDC37_N X 13248 +CSNK2A1 CK2A1 P68400 human TRHR 25570 Q01717 Trhr rat T365 465592 KEsDRFstELDDItV X +CSNK2A1 CK2A1 P68400 human SPTBN1 6711 Q01082 SPTBN1 human T2159 471399 NGAtEQRtssKEssP X +CSNK2A1 CK2A1 P68400 human TAT-SF1 27336 O43719 HTATSF1 human S748 18016601 GSsFILssDDDDDDI X X +CSNK2A1 CK2A1 P68400 human CHD-4 1108 Q14839 CHD4 human S308 471447 FGskRKRsssEDDDL X +CSNK2A1 CK2A1 P68400 human MAX 4149 P61244 MAX human S11 449308 NDDIEVEsDEEQPRF X +CSNK2A1 CK2A1 P68400 human RPS5 20103 P97461 Rps5 mouse S24 9819906 IkLFGkWsTDDVQIN X +CSNK2A1 CK2A1 P68400 human RPAP3 79657 Q9H6T3 RPAP3 human S121 1279825 sLsQEsEsEEdGIHV X X +CSNK2A1 CK2A1 P68400 human PSEN2 5664 P49810 PSEN2 human S335 449963 YDsFGEPsYPEVFEP Presenilin X +CSNK2A1 CK2A1 P68400 human TSPY1 7258 Q01534 TSPY1 human T300 460704 PPEEGTEtSGDSQLL X +CSNK2A1 CK2A1 P68400 human DTD1 92675 Q8TEA8 DTD1 human S181 36396300 RAKGPsEssKERNtP X +CSNK2A1 CK2A1 P68400 human PKD2 5311 Q13563 PKD2 human S812 451598 FPRsLDDsEEDDDED X +CSNK2A1 CK2A1 P68400 human MCM2 4171 P49736 MCM2 human S53 473058 LPPFEDEsEGLLGtE MCM2_N X +CSNK2A1 CK2A1 P68400 human HSP90B 3326 P08238 HSP90AB1 human S255 449266 PKIEDVGsDEEDDsG HSP90 X X +CSNK2A1 CK2A1 P68400 human CDC25C 995 P30307 CDC25C human T236 451436 VEKFkDNtIPDkVKK M-inducer_phosp X X +CSNK2A1 CK2A1 P68400 human PML 5371 P29590 PML human S560 6835504 EERVVVIsssEDsDA DUF3583 X +CSNK2A1 CK2A1 P68400 human DDHD1 338047 O46606 DDHD1 cow S93 465581 SDDNYDFsSAESGSS X +CSNK2A1 CK2A1 P68400 human PER2 8864 O15055 PER2 human S696 468399 EMVEDAAsGPEsLDC X X +CSNK2A1 CK2A1 P68400 human ER-alpha 2099 P03372 ESR1 human S559 6048400 PTsRGGAsVEETDQS ESR1_C X X +CSNK2A1 CK2A1 P68400 human NCL 25135 P13383 Ncl rat S34 466005 DsEDEEMsEDEDDss X +CSNK2A1 CK2A1 P68400 human HDAC1 3065 Q13547 HDAC1 human S423 447913 CEEEFsDsEEEGEGG X X +CSNK2A1 CK2A1 P68400 human MRE11A 4361 P49959 MRE11 human S689 452321 KGVDFEssEDDDDDP X X +CSNK2A1 CK2A1 P68400 human ARRB2 iso2 281638 P32120-2 ARRB2 cow T382 455373 EFETNYAtDDDIVFE X +CSNK2A1 CK2A1 P68400 human G3BP-1 10146 Q13283 G3BP1 human S149 449041 VtEPQEEsEEEVEEP X X +CSNK2A1 CK2A1 P68400 human MYH10 4628 P35580 MYH10 human S1975 465603 NEtQPPQsE______ X +CSNK2A1 CK2A1 P68400 human CDH1 12550 P09803 Cdh1 mouse S848 15754601 GsEAAsLssLNSsEs CADH_Y-type_LIR X +CSNK2A1 CK2A1 P68400 human CTDP1 9150 Q9Y5B0 CTDP1 human S944 455467 NEDEGsssEADEMAK FCP1_C X +CSNK2A1 CK2A1 P68400 human XPC 7508 Q01831 XPC human S129 14161729 sNEEEEEsENDWEEV X +CSNK2A1 CK2A1 P68400 human MCM2 4171 P49736 MCM2 human S139 454180 RRGLLyDsDEEDEER MCM2_N X 8861; 12958 +CSNK2A1 CK2A1 P68400 human Myf-5 4617 P13349 MYF5 human S49 457384 HKAELQGsDEDEHVR Basic X +CSNK2A1 CK2A1 P68400 human PER2 8864 O15055 PER2 human S700 468400 DAAsGPEsLDCLAGP X +CSNK2A1 CK2A1 P68400 human HDAC1 3065 Q13547 HDAC1 human S421 447912 IACEEEFsDsEEEGE X X +CSNK2A1 CK2A1 P68400 human FURIN 5045 P09958 FURIN human S773 469742 AWQEECPsDsEEDEG X +CSNK2A1 CK2A1 P68400 human TEBP 10728 Q15185 PTGES3 human S113 451129 WKDWEDDsDEDMsNF X X +CSNK2A1 CK2A1 P68400 human DTD1 92675 Q8TEA8 DTD1 human S197 1983955 KEDRsAssGAEGDVs X +CSNK2A1 CK2A1 P68400 human HS1 3059 P14317 HCLS1 human T23 11349501 tQGDDWDtDPDFVND X +CSNK2A1 CK2A1 P68400 human NPHP1 4867 O15259 NPHP1 human S123 26395107 EEEEEsEsEDsEDSG X X +CSNK2A1 CK2A1 P68400 human DARPP-32 360616 Q6J4I0 Ppp1r1b rat S102 457675 NLsENQAsEEEDELG DARPP-32 X 3401 +CSNK2A1 CK2A1 P68400 human Sialoprotein-2 281233 Q28862 IBSP cow S300 457546 YKGRGYDsYDGQDYY BSP_II X +CSNK2A1 CK2A1 P68400 human MDM2 4193 Q00987 MDM2 human S269 455458 sEEGQELsDEDDEVy X +CSNK2A1 CK2A1 P68400 human KIR3DL1 3811 P43629 KIR3DL1 human S385 990304 AGNRTANsEDsDEQD X +CSNK2A1 CK2A1 P68400 human DAXX 1616 Q9UER7 DAXX human S739 467727 EIIVLsDsD______ X X +CSNK2A1 CK2A1 P68400 human FNIP1 96459 Q8TF40 FNIP1 human S938 1861699800 WDIPRNEssDsALGD X +CSNK2A1 CK2A1 P68400 human MSK1 9252 O75582 RPS6KA5 human T793 12159000 ADSNNPEtLFQFSDS X +CSNK2A1 CK2A1 P68400 human hnRNP A1 3178 P09651 HNRNPA1 human S199 451555 sQrGrsGsGNFGGGr X +CSNK2A1 CK2A1 P68400 human SRC-2 10499 Q15596 NCOA2 human S487 4728845 GQPTSMLsPrHRMsP NCOA_u2 X +CSNK2A1 CK2A1 P68400 human GRB14 2888 Q14449 GRB14 human S366 29576856 GCSsQSIsPMRsIsE X +CSNK2A1 CK2A1 P68400 human PTEN 5728 P60484 PTEN human T382 448314 DHyRYsDttDsDPEN X X 9554; 9549; 7960 +CSNK2A1 CK2A1 P68400 human Myc 4609 P01106 MYC human S362 466010 RKCtsPrssDtEENV X +CSNK2A1 CK2A1 P68400 human NCAPG 64151 Q9BPX3 NCAPG human S973 3210609 CQtAEADsEsDHEVP X +CSNK2A1 CK2A1 P68400 human CAPZA1 829 P52907 CAPZA1 human S9 457555 ADFDDrVsDEEkVRI X X +CSNK2A1 CK2A1 P68400 human hnRNP C1/C2 3183 P07910 HNRNPC human S260 448833 sEGGADDsAEEGDLL X +CSNK2A1 CK2A1 P68400 human USP7 7874 Q93009 USP7 human S18 449238 KAGEQQLsEPEDMEM X X +CSNK2A1 CK2A1 P68400 human NRL 4901 P54845 NRL human S117 1880112600 PHGYYPGsPEETGAQ X +CSNK2A1 CK2A1 P68400 human Sialoprotein-2 281233 Q28862 IBSP cow S75 457542 EENGNGDssEEEEEE BSP_II X +CSNK2A1 CK2A1 P68400 human SEC63 11231 Q9UGP8 SEC63 human S576 27440600 VsDKGsDsEEEETNR X X +CSNK2A1 CK2A1 P68400 human LASS6 253782 Q6ZMG9 CERS6 human S345 22350306 DDRsDIEsssDEEDS X +CSNK2A1 CK2A1 P68400 human CPLX1 768228 Q0IIL7 CPLX1 cow S115 474557 AAEEEDEsILDTVIK Synaphin X +CSNK2A1 CK2A1 P68400 human TELO2 9894 Q9Y4R8 TELO2 human S485 27530803 PQAQLAGsDsDLDsD X X +CSNK2A1 CK2A1 P68400 human TTI1 9675 O43156 TTI1 human S828 9765114 DVADGNVsDFDNEEE X X +CSNK2A1 CK2A1 P68400 human CREB 1385 P16220 CREB1 human S94 451807 QISTIAEsEDsQEsV X +CSNK2A1 CK2A1 P68400 human CFTR 12638 P26361 Cftr mouse T1467 21440502 ITALKEEtEEEVQET X +CSNK2A1 CK2A1 P68400 human SET iso2 6418 Q01105-2 SET human S9 6308300 sAPAAkVsKkELNsN X +CSNK2A1 CK2A1 P68400 human MSK1 9252 O75582 RPS6KA5 human S759 12159003 sTETRssssESSHSs X +CSNK2A1 CK2A1 P68400 human OTUD5 55593 Q96G74 OTUD5 human S177 449291 EVGAGyNsEDEyEAA X +CSNK2A1 CK2A1 P68400 human FNIP1 96459 Q8TF40 FNIP1 human S948 4734337 sALGDsEsEDTGHDM X +CSNK2A1 CK2A1 P68400 human FN1 iso1 2335 P02751-1 FN1 human S2384 467903 VQADREDsRE_____ X +CSNK2A1 CK2A1 P68400 human CFTR 1080 P13569 CFTR human S422 3333404 NNNNRktsNGDDsLF X X +CSNK2A1 CK2A1 P68400 human FANCD2 2177 Q9BXW9 FANCD2 human T884 1871613603 SkTSSsDtLsEEkNs FancD2 X +CSNK2A1 CK2A1 P68400 human CDC25B 994 P30305 CDC25B human S186 448746 EAGsGAAsssGEDkE M-inducer_phosp X +CSNK2A1 CK2A1 P68400 human occludin 100506658 Q16625 OCLN human S408 2906719 DyttGGEsCDELEED X X +CSNK2A1 CK2A1 P68400 human DOK7 231134 Q18PE0 Dok7 mouse S265 41621602 GDDRSLsssSSEASH X +CSNK2A1 CK2A1 P68400 human MCM2 4171 P49736 MCM2 human S27 452310 GNDPLtssPGRssRR X +CSNK2A1 CK2A1 P68400 human SIRT1 93759 Q923E4 Sirt1 mouse S683 9993600 EEPLEDEsEIEEFYN X X +CSNK2A1 CK2A1 P68400 human PEDF 5176 P36955 SERPINF1 human S114 455232 ALYYDLIsSPDIHGT Serpin X +CSNK2A1 CK2A1 P68400 human LASS5 91012 Q8N5B7 CERS5 human S355 18260885 DRsDVEsssEEEDVT X +CSNK2A1 CK2A1 P68400 human HOXB7 3217 P09629 HOXB7 human S132 465569 RIYPWMRssGTDRKR X +CSNK2A1 CK2A1 P68400 human WAVE2 10163 Q9Y6W5 WASF2 human S489 6377640 sDsEDDssEFDEDDW X +CSNK2A1 CK2A1 P68400 human CREB iso1 81646 P15337-1 Creb1 rat S108 451807 QISTIAEsEDsQEsV X +CSNK2A1 CK2A1 P68400 human TOP2A 7153 P11388 TOP2A human S1365 18016961 TKtsPKLsNkELKPQ X +CSNK2A1 CK2A1 P68400 human Sialoprotein-2 281233 Q28862 IBSP cow S31 457538 RRAKLEDsEENGVFK BSP_II X +CSNK2A1 CK2A1 P68400 human FANCD2 2177 Q9BXW9 FANCD2 human T896 27448950 kNsECDPtPsHRGQL FancD2 X X +CSNK2A1 CK2A1 P68400 human Myc 4609 P01106 MYC human S363 466011 KCtsPrssDtEENVk X +CSNK2A1 CK2A1 P68400 human p53 7157 P04637 TP53 human S149 456326 PVQLWVDstPPPGtR P53 X +CSNK2A1 CK2A1 P68400 human NFkB-p65 19697 Q04207 Rela mouse S527 447799 SGLPNGLsGDEDFss X X +CSNK2A1 CK2A1 P68400 human TR-alpha iso5 21833 P63058_OBS Thra mouse S475 449310 SSLSSSssDEDTEVF X +CSNK2A1 CK2A1 P68400 human VDR 7421 P11473 VDR human S208 456982 SFSNLDLsEEDSDDP X X +CSNK2A1 CK2A1 P68400 human VHL 7428 P40337 VHL human S38 15573200 EEsGAEEsGPEEsGP X +CSNK2A1 CK2A1 P68400 human Wee1 7465 P30291 WEE1 human S121 456468 WEEEGFGsSsPVKsP X +CSNK2A1 CK2A1 P68400 human p53 7157 P04637 TP53 human T55 450685 DDIEQWFtEDPGPDE TAD2 X +CSNK2A1 CK2A1 P68400 human occludin 100506658 Q16625 OCLN human T400 471470 tEQDHyEtDyttGGE X X +CSNK2A1 CK2A1 P68400 human IkB-alpha 4792 P25963 NFKBIA human T299 456335 EsEFTEFtEDELPyD X +CSNK2A1 CK2A1 P68400 human Ikaros 22778 Q03267 Ikzf1 mouse S63 451348 NVkVETQsDEENGRA X +CSNK2A1 CK2A1 P68400 human DTD1 92675 Q8TEA8 DTD1 human S179 23112003 KTRAKGPsEssKERN X +CSNK2A1 CK2A1 P68400 human BMAL1 11865 Q9WTL8 Bmal1 mouse S97 7359500 RRRDKMNsFIDELAS HLH X +CSNK2A1 CK2A1 P68400 human SLC18A2 25549 Q01827 Slc18a2 rat S512 465595 PIGDDEEsEsD____ X +CSNK2A1 CK2A1 P68400 human CETN1 1068 Q12798 CETN1 human T138 34405000 NELGENLtDEELQEM EF-hand_7 X +CSNK2A1 CK2A1 P68400 human PSMA3 29670 P18422 Psma3 rat S243 451184 AEkyAKEsLKEEDEs X +CSNK2A1 CK2A1 P68400 human TOP2A 7153 P11388 TOP2A human S1377 448765 KPQKsVVsDLEADDV X +CSNK2A1 CK2A1 P68400 human TIF1A 54700 Q9NYV6 RRN3 human S172 470002 GDVDVsDsDDEDDNL RRN3 X X +CSNK2A1 CK2A1 P68400 human LDLR 281276 P01131 LDLR cow S258 465609 YPSRQMVsLEDDVA_ X +CSNK2A1 CK2A1 P68400 human CDC34 997 P49427 CDC34 human S236 448690 DDsGtEEs_______ X X +CSNK2A1 CK2A1 P68400 human CK2A1 1457 P68400 CSNK2A1 human Y182 10294400 DWGLAEFyHPGQEYN Pkinase X +CSNK2A1 CK2A1 P68400 human SSRP1 6749 Q08945 SSRP1 human S657 456295 KSssRQLsEsFksKE X +CSNK2A1 CK2A1 P68400 human CDK1 983 P06493 CDK1 human S39 455465 MkkIRLEsEEEGVPs Pkinase X X +CSNK2A1 CK2A1 P68400 human FosB 2354 P53539 FOSB human S27 465535 SAESQYLsSVDSFGS X X +CSNK2A1 CK2A1 P68400 human FETUA 280988 P12763 AHSG cow S324 471394 GVAsVEssSGEAFHV X +CSNK2A1 CK2A1 P68400 human DLG3 58948 Q62936 Dlg3 rat S632 4710993 KGVTSNTsDSESSSK X +CSNK2A1 CK2A1 P68400 human Caldesmon 373965 P12957 CALD1 chicken S73 457422 SEVNAQNsVAEEETK Caldesmon X +CSNK2A1 CK2A1 P68400 human FNIP1 96459 Q8TF40 FNIP1 human S941 4734327 PRNEssDsALGDsEs X +CSNK2A1 CK2A1 P68400 human p70S6K 83840 P67999 Rps6kb1 rat S40 450117 DQPEDAGsEDELEEG X +CSNK2A1 CK2A1 P68400 human IkB-alpha 4792 P25963 NFKBIA human S32 448203 LLDDRHDsGLDsMkD X 5210; 2859; 9246; 5209 +CSNK2A1 CK2A1 P68400 human ATF-1 466 P18846 ATF1 human S51 15725602 SSDsIGssQKAHGIL pKID X +CSNK2A1 CK2A1 P68400 human CK2B 1460 P67870 CSNK2B human S2 447646 ______MsssEEVsW X +CSNK2A1 CK2A1 P68400 human EVI1 2122 Q03112 MECOM human S726 4703001 PLkMEPQsPGEVKKL X X +CSNK2A1 CK2A1 P68400 human GBF1 8729 Q92538 GBF1 human S292 1170755600 VVSPSTDsGLEFsSQ X X +CSNK2A1 CK2A1 P68400 human Ikaros 22778 Q03267 Ikzf1 mouse S13 4828300 GQDMSQVsGKESPPV X +CSNK2A1 CK2A1 P68400 human Ikaros 22778 Q03267 Ikzf1 mouse T393 451353 sNsCQDstDtEsNAE X +CSNK2A1 CK2A1 P68400 human DDHD1 338047 O46606 DDHD1 cow S105 465582 GSSLRYYsEGESGGG X +CSNK2A1 CK2A1 P68400 human SLC3A2 6520 P08195 SLC3A2 human S531 6003501 RRLsDQRsKERSLLH X +CSNK2A1 CK2A1 P68400 human TRHR 25570 Q01717 Trhr rat T371 465593 stELDDItVTDtYVs X +CSNK2A1 CK2A1 P68400 human ARRB2 216869 Q91YI4 Arrb2 mouse T383 455373 EFDTNYAtDDDIVFE X X +CSNK2A1 CK2A1 P68400 human PACSIN1 23969 Q61644 Pacsin1 mouse S358 4730500 QTYATEWsDDEsGNP X +CSNK2A1 CK2A1 P68400 human DTD1 92675 Q8TEA8 DTD1 human S182 36396301 AKGPsEssKERNtPR X +CSNK2A1 CK2A1 P68400 human MLH1 4292 P40692 MLH1 human S477 480003 RKRHREDsDVEMVED X X +CSNK2A1 CK2A1 P68400 human SERINC3 10955 Q13530 SERINC3 human S383 1255792400 DTTTsGAsDEEDGQP Serinc X X +CSNK2A1 CK2A1 P68400 human FGA 2243 P02671 FGA human S609 466008 KMADEAGsEADHEGt X +CSNK2A1 CK2A1 P68400 human PR 5241 P06401 PGR human S81 450160 TQDQQsLsDVEGAys Prog_receptor X X +CSNK2A1 CK2A1 P68400 human LASS5 91012 Q8N5B7 CERS5 human S354 18260882 DDRsDVEsssEEEDV X +CSNK2A1 CK2A1 P68400 human SNCA 6622 P37840 SNCA human S129 448278 NEAyEMPsEEGyQDy Synuclein X X 23706; 87281 +CSNK2A1 CK2A1 P68400 human FETUA 280988 P12763 AHSG cow S320 467423 HTFSGVAsVEssSGE X +CSNK2A1 CK2A1 P68400 human PDCD5 9141 O14737 PDCD5 human S119 452536 NRRKVMDsDEDDDy_ X X +CSNK2A1 CK2A1 P68400 human CREB iso1 81646 P15337-1 Creb1 rat S142 448547 RkILNDLssDAPGVP pKID X +CSNK2A1 CK2A1 P68400 human IGFBP1 3484 P08833 IGFBP1 human S194 451660 LAKAQETsGEEIsKF Thyroglobulin_1 X X +CSNK2A1 CK2A1 P68400 human factor V 2153 P12259 F5 human S720 451408 LEPEDEEsDADYDYQ X +CSNK2A1 CK2A1 P68400 human SLC3A2 6520 P08195 SLC3A2 human S410 6003502 syLsDsGsTGEHTkS X +CSNK2A1 CK2A1 P68400 human MSK1 9252 O75582 RPS6KA5 human S758 455798 tsTETRssssESSHS X +CSNK2A1 CK2A1 P68400 human DNMT3A 1788 Q9Y6K1 DNMT3A human S393 17548182 VCHDsDEsDTAKAVE X X +CSNK2A1 CK2A1 P68400 human SAT 6303 P21673 SAT1 human S149 11390101 RRGAsDLsSEEGWRL X +CSNK2A1 CK2A1 P68400 human IkB-beta 4793 Q15653 NFKBIB human S315 452014 sGPCSsSsDSDSGDE X +CSNK2A1 CK2A1 P68400 human MSK2 8986 O75676 RPS6KA4 human S324 11489900 PFRPQIRsELDVGNF Pkinase_C X +CSNK2A1 CK2A1 P68400 human B-Myb 4605 P10244 MYBL2 human T18 465554 DELHyQDtDsDVPEQ X +CSNK2A1 CK2A1 P68400 human LIG1 3978 P18858 LIG1 human S66 448498 KAARVLGsEGEEEDE X +CSNK2A1 CK2A1 P68400 human TEBP 10728 Q15185 PTGES3 human S118 451130 DDsDEDMsNFDRFsE X X +CSNK2A1 CK2A1 P68400 human AP-2 alpha 7020 P05549 TFAP2A human S429 20797701 TDNNAKssDKEEKHR X X +CSNK2A1 CK2A1 P68400 human CTDP1 9150 Q9Y5B0 CTDP1 human S740 453872 TkAQRENsPAAFPDR FCP1_C X +CSNK2A1 CK2A1 P68400 human eIF2-beta 8894 P20042 EIF2S2 human S67 450072 DTRKkDAsDDLDDLN X X +CSNK2A1 CK2A1 P68400 human RAD1 5810 O60671 RAD1 human S282 14881301 EEVPEsEs_______ X +CSNK2A1 CK2A1 P68400 human RGS19 10287 P49795 RGS19 human S24 449957 ADRPPSMsSHDTASP X +CSNK2A1 CK2A1 P68400 human LXR-alpha 10062 Q13133 NR1H3 human S198 469114 SLPPRASsPPQILPQ X X +CSNK2A1 CK2A1 P68400 human ACE2 59272 Q9BYF1 ACE2 human S787 1868161400 PyAsIDIsKGENNPG X +CSNK2A1 CK2A1 P68400 human eIF4G iso8 1981 Q04637-8 EIF4G1 human S1239 18910225 sPLKAALsEEELEKK X X +CSNK2A1 CK2A1 P68400 human CHD-4 1108 Q14839 CHD4 human S428 470519 WEAKEDNsEGEEILE X +CSNK2A1 CK2A1 P68400 human PML 5371 P29590 PML human S561 6835503 ERVVVIsssEDsDAE DUF3583 X +CSNK2A1 CK2A1 P68400 human C/EBP-beta 24253 P21272 Cebpb rat S223 408589401 kkAVDKLsDEYKMRR bZIP_2 X +CSNK2A1 CK2A1 P68400 human SRC-2 10499 Q15596 NCOA2 human S469 4728825 NYALKMNsPsQSsPG NCOA_u2 X +CSNK2A1 CK2A1 P68400 human MED17 234959 Q8VCD5 Med17 mouse S53 4765330 RIDFSQGsGsEEEEA X X +CSNK2A1 CK2A1 P68400 human SRF 6722 P11831 SRF human S77 451802 PTAGALYsGsEGDsE X +CSNK2A1 CK2A1 P68400 human PML 5371 P29590 PML human S562 6835502 RVVVIsssEDsDAEN DUF3583 X +CSNK2A1 CK2A1 P68400 human CLOCK 9575 O15516 CLOCK human S106 1881001400 DWKPTFLsNEEFTQL X X +CSNK2A1 CK2A1 P68400 human PhLP 64013 Q63737 Pdcl rat S20 448825 LQYYYstsEDEDsDH X +CSNK2A1 CK2A1 P68400 human PIK3R1 5295 P27986 PIK3R1 human S608 448133 ENtEDQysLVEDDED X +CSNK2A1 CK2A1 P68400 human TOP1 7150 P11387 TOP1 human S10 465604 GDHLHNDsQIEADFR X +CSNK2A1 CK2A1 P68400 human Sialoprotein-2 P13839 Ibsp rat S77 457543 ENGDGDssEEEGEEE BSP_II X +CSNK2A1 CK2A1 P68400 human Geminin 51053 O75496 GMNN human S184 25535401 EEETVEDsLVEDSEI Geminin X +CSNK2A1 CK2A1 P68400 human CD5 921 P06127 CD5 human S483 450127 sMQPDNssDsDyDLH X X +VRK2 VRK2 iso2 Q86Y07-2 human p53 22059 P02340 Tp53 mouse S18 447490 IsLELPLsQEtFsGL P53_TAD X 9284; 9286; 12571; 56979 +VRK2 VRK2 iso2 Q86Y07-2 human p53 22059 P02340 Tp53 mouse T21 447541 ELPLsQEtFsGLWKL P53_TAD X X +AURKA AurA O14965 human syntenin 6386 O00560 SDCBP human T200 1869341900 RPFERTItMHKDSTG PDZ; Peptidase_M50 X X +AURKA AurA O14965 human CRMP-1 1400 Q14194 CRMP1 human T101 11539300 RAALVGGttMIIDHV Amidohydro_1 X +AURKA AurA O14965 human WDR62 284403 O43379 WDR62 human S49 3175148 LRRRtRLstAsEEtV X +AURKA AurA O14965 human FAF1 11124 Q9UNN5 FAF1 human S291 450287 DVHMVsDsDGDDFED X X +AURKA AurA O14965 human WDR62 284403 O43379 WDR62 human T50 1246205 RRRtRLstAsEEtVQ X +AURKA AurA O14965 human TPX2 398174 Q6NUF4 tpx2.L frog S48 457642 PPDQRRLsETSVNTE Aurora-A_bind X +AURKA AurA O14965 human AurA 6790 O14965 AURKA human S67 457664 QAQkLVssHkPVQNQ X +AURKA AurA O14965 human SECISBP2L 9728 Q93073 SECISBP2L human T573 1868832803 IAKLKRPtALKKVIL X X +AURKA AurA O14965 human AurA 6790 O14965 AURKA human T287 457654 HAPSsRRttLCGtLD Pkinase X +AURKA AurA O14965 human ATP6V1A 11964 P50516 Atp6v1a mouse S175 14913505 LPPRNRGsVTYIAPP ATP-synt_ab_Xtn X X +AURKA AurA O14965 human ARPC1B 10095 O15143 ARPC1B human T21 10349703 HAWNkDRtQIAICPN X +AURKA AurA O14965 human NuMA-1 4926 Q14980 NUMA1 human S1887 3196640 tRssARRsQAGVsSG X +AURKA AurA O14965 human MCRS1 10445 Q96EZ8 MCRS1 human S36 40268168 AGQkRAssQALGTIP X X +AURKA AurA O14965 human SPAG5 10615 Q96R06 SPAG5 human S115 34824800 IsStPkTsEEAVDPL X X +AURKA AurA O14965 human dynactin 1 1639 Q14203 DCTN1 human S19 455515 TPSGSrMsAEAsArP X +AURKA AurA O14965 human AML2 864 Q13761 RUNX3 human T14 4733089 PSTSRRFtPPsPAFP X +AURKA AurA O14965 human ALDH1A1 216 P00352 ALDH1A1 human T493 63070900 yTEVkTVtVkISQKN X X +AURKA AurA O14965 human YAP1 10413 P46937 YAP1 human S397 3190672 tyHSRDEstDsGLsM X X +AURKA AurA O14965 human AurA 6790 O14965 AURKA human Y148 457653 kGkFGNVyLAREKQS Pkinase X +AURKA AurA O14965 human PRMT5 10419 O14744 PRMT5 human S103 1881955602 VEKIRRNsEAAMLQE X X +AURKA AurA O14965 human AurA 6790 O14965 AURKA human S266 457669 PENLLLGsAGELKIA Pkinase X +AURKA AurA O14965 human ARHGEF2 9181 Q92974 ARHGEF2 human S886 451365 PVDPRRRsLPAGDAL X X +AURKA AurA O14965 human FAF1 11124 Q9UNN5 FAF1 human S289 450286 ITDVHMVsDsDGDDF X X +AURKA AurA O14965 human AurA 6790 O14965 AURKA human S278 457670 KIADFGWsVHAPSsR Pkinase X +AURKA AurA O14965 human SPIN1 10927 Q9Y657 SPIN1 human S124 3217695 RVAtSRIsDAHLADt X X +AURKA AurA O14965 human WDR62 284403 O43379 WDR62 human S33 453570 PARRGQssPPPAPPI X +AURKA AurA O14965 human BRCA1 672 P38398 BRCA1 human S308 451604 KAEFCNKskQPGLAR X X +AURKA AurA O14965 human SKI 6497 P12755 SKI human S383 11145003 LsAFRPWsPAVSASE X +AURKA AurA O14965 human CRMP-1 1400 Q14194 CRMP1 human T102 11539301 AALVGGttMIIDHVV Amidohydro_1 X +AURKA AurA O14965 human LDH-B 3945 P07195 LDHB human S162 31882222 PkHrVIGsGCNLDsA X X +AURKA AurA O14965 human PAX8 7849 Q06710 PAX8 human S209 1877752105 DQDSCRLsIDSQSSS X +AURKA AurA O14965 human KIF2C 380006 Q91636 kif2c frog S719 3545002 LQVEEQAsKQISKKK X +AURKA AurA O14965 human MYBBP1A 10514 Q9BQG0 MYBBP1A human S1303 3210687 ARKKARLsLVIRsPs X +AURKA AurA O14965 human GSK3B 2932 P49841 GSK3B human S9 449111 SGRPRttsFAEsCkP X X 9336; 9331; 9327; 9323; 9322; 9325; 5558; 8566; 79774; 8466; 25462; 14026; 14332; 14310; 14630 +AURKA AurA O14965 human PHLDA1 22822 Q8WV24 PHLDA1 human S95 22459800 PLCLLRVsLLCALRA X +AURKA AurA O14965 human CENPJ 55835 Q9HC77 CENPJ human S467 31855585 LKCSNRksLsPsGLK X X +AURKA AurA O14965 human CETN2 1069 P41208 CETN2 human S170 448199 LRIMkKTsLY_____ X X +AURKA AurA O14965 human KIF4A 24137 O95239 KIF4A human T799 479906 PPKLRRRtFsLTEVR X X +AURKA AurA O14965 human CPEB 12877 P70166 Cpeb1 mouse T171 449610 VRGSRLDtRPILDsR CEBP1_N X +AURKA AurA O14965 human HAUS8 93323 Q9BT25 HAUS8 human S20 20583301 ATGPTNsssAKKKDK X X +AURKA AurA O14965 human PAX8 7849 Q06710 PAX8 human T277 1877752106 TLDDGkAtLTPSNTP X +AURKA AurA O14965 human NuMA-1 4926 Q14980 NUMA1 human T1811 1245323 tRsARRRttQIINIt X +AURKA AurA O14965 human VHL 7428 P40337 VHL human S72 469117 SVNsREPsQVIFCNr VHL X X +AURKA AurA O14965 human LIMK2 3985 P53671 LIMK2 human T494 467206 kATTKKRtLRKNDRK PK_Tyr_Ser-Thr X X +AURKA AurA O14965 human PAR3-alpha 56288 Q8TEW0 PARD3 human S962 11279402 SSRsGREsVSTAsDQ X X +AURKA AurA O14965 human TPX2 398174 Q6NUF4 tpx2.L frog S90 459997 KSQSKRSsRRMsKKH X +AURKA AurA O14965 human NEDD1 121441 Q8NHV4 NEDD1 human S405 4706050 FDDtGKssLGDMFsP X X +AURKA AurA O14965 human AurA 6790 O14965 AURKA human S226 457668 YRELQKLskFDEQRT Pkinase X +AURKA AurA O14965 human NDEL1 83431 Q9ERR1 Ndel1 mouse S251 474509 LtPSARIsALNIVGD NUDE_C X X +AURKA AurA O14965 human PLK1 5347 P53350 PLK1 human T210 448139 YDGERKktLCGtPNy Pkinase X X 4354; 5472; 9062 +AURKA AurA O14965 human ER-alpha 2099 P03372 ESR1 human S167 448102 GGRERLAsTNDkGSM Oest_recep X X 64508; 42101 +AURKA AurA O14965 human NPM1 4869 P06748 NPM1 human S125 459897 AVEEDAEsEDEEEED X X +AURKA AurA O14965 human DLG7 9787 Q15398 DLGAP5 human S627 456345 VKLFsGLsVssEGPs X +AURKA AurA O14965 human AurA 6790 O14965 AURKA human T16 457662 IsGPVkAtAPVGGPk X +AURKA AurA O14965 human FADD 8772 Q13158 FADD human S203 22496704 MsWNsDAsTSEAS__ X X +AURKA AurA O14965 human LATS2 26524 Q9NRM7 LATS2 human S83 451703 ALREIRysLLPFANE X X +AURKA AurA O14965 human SKI 6497 P12755 SKI human S326 41656200 RRVPRVssEPPASIR X +AURKA AurA O14965 human p73 7161 O15350 TP73 human S235 23481800 DPVTGRQsVVVPYEP P53 X X +AURKA AurA O14965 human AurA 6790 O14965 AURKA human S10 457661 RsKENCIsGPVkAtA X +AURKA AurA O14965 human HEC1 10403 O14777 NDC80 human S44 474539 kPtFGkLsINkPtsE X +AURKA AurA O14965 human MCRS1 10445 Q96EZ8 MCRS1 human S35 14575930 LAGQkRAssQALGTI X X +AURKA AurA O14965 human NuMA-1 4926 Q14980 NUMA1 human S2047 4748253 kQADRRQsMAFsILN X +AURKA AurA O14965 human MBD3 53615 O95983 MBD3 human S85 1210518 RQRVRyDssNQVKGk MBDa X X +AURKA AurA O14965 human CtIP 5932 Q99708 RBBP8 human S593 4766307 IPLRPREsLETENVL X X +AURKA AurA O14965 human H3 8350 P68431 H3C1 human S10 455676 tkQtArkstGGkAPr Histone X X 9701; 9711; 9606; 3465; 3642; 3377; 3475; 3458; 5764; 47398; 8481; 8552; 53348; 29237; 66065; 43185; 64522; 52725 +AURKA AurA O14965 human CtIP 5932 Q99708 RBBP8 human S327 452473 ELPtRVssPVFGATS X +AURKA AurA O14965 human MAP9 79884 Q49MG5 MAP9 human S625 999603 RKQKKRHsFLESEAL X X +AURKA AurA O14965 human CPEB 12877 P70166 Cpeb1 mouse S177 483983 DtRPILDsRSSsPSD CEBP1_N X +AURKA AurA O14965 human SIRT1 23411 Q96EB6 SIRT1 human T344 25594500 GkLLRNYtQNIDTLE SIR2 X X +AURKA AurA O14965 human SPIN1 10927 Q9Y657 SPIN1 human S109 24976101 LNkDERVsALEVLPD X X +AURKA AurA O14965 human PSEN2 5664 P49810 PSEN2 human S19 449962 EVCDERTsLMsAEsP X +AURKA AurA O14965 human KCTD12 115207 Q96CX2 KCTD12 human S243 18011104 ITVCGKTsLAkEVFG X +AURKA AurA O14965 human NuMA-1 4926 Q14980 NUMA1 human S1883 31033004 YrPttRssARRsQAG X +AURKA AurA O14965 human ALDH1A1 216 P00352 ALDH1A1 human T442 63070901 kDIDKAItISSALQA Aldedh X X +AURKA AurA O14965 human AurA 6790 O14965 AURKA human S41 457663 QNPLPVNsGQAQRVL X +AURKA AurA O14965 human BIM 10018 O43521 BCL2L11 human S98 8080218 RSssGyFsFDTDRsP X X +AURKA AurA O14965 human syntenin 6386 O00560 SDCBP human S131 56649728 kIGLRLKsIDNGIFV PDZ; Peptidase_M50 X X +AURKA AurA O14965 human IkB-alpha 4792 P25963 NFKBIA human S63 1873119300 PQEVPRGsEPWkQQL X +AURKA AurA O14965 human PKD2 5311 Q13563 PKD2 human S829 4696848 HSSRRRGsISSGVSY X +AURKA AurA O14965 human Cas-L 4739 Q14511 NEDD9 human S296 4696722 PVARRHQsLsPNHPP X +AURKA AurA O14965 human MAP9 79884 Q49MG5 MAP9 human S305 11334001 AVEKSKEsQVTADDL X +AURKA AurA O14965 human WHSC1 7468 O96028 NSD2 human S56 12667955 SkAQLSSsLQEGVMQ X +AURKA AurA O14965 human LATS2 26524 Q9NRM7 LATS2 human S380 3213669 ATLARRDsLQKPGLE X X +AURKA AurA O14965 human DLG7 9787 Q15398 DLGAP5 human S725 456346 CLssERMsLPLLAGG X X +AURKA AurA O14965 human IkB-alpha 4792 P25963 NFKBIA human S262 1873119302 QLTWGRPsTRIQQQL X +AURKA AurA O14965 human LIMK2 3985 P53671 LIMK2 human T505 448683 NDRKKRYtVVGNPYW PK_Tyr_Ser-Thr X X 3841 +AURKA AurA O14965 human AML2 864 Q13761 RUNX3 human T173 55571501 YHRAIkVtVDGPREP Runt X +AURKA AurA O14965 human DLG7 9787 Q15398 DLGAP5 human S830 456348 QEHARHIsFGGNLIt X +AURKA AurA O14965 human HEC1 10403 O14777 NDC80 human S55 459763 PtsERkVsLFGkRts Ndc80_HEC X X +AURKA AurA O14965 human TPX2 22974 Q9ULW0 TPX2 human S121 459996 PAQPQRRsLRLsAQk X X +AURKA AurA O14965 human AurA 6790 O14965 AURKA human S98 457666 PLNNTQKskQPLPsA X +AURKA AurA O14965 human HAUS8 93323 Q9BT25 HAUS8 human S19 20583302 PATGPTNsssAKKKD X X +AURKA AurA O14965 human EB3 22924 Q9UPY8 MAPRE3 human S176 4740060 MQTSGRLsNVAPPCI X X +AURKA AurA O14965 human NuMA-1 4926 Q14980 NUMA1 human T2084 31033005 sPNtRSGtRRsPRIA X +AURKA AurA O14965 human p53 7157 P04637 TP53 human S106 27300200 sQkTYQGsYGFrLGF P53 X X +AURKA AurA O14965 human POU6F1 5463 Q14863 POU6F1 human S197 1869383200 kLDITPKsAQKLKPV Pou X X +AURKA AurA O14965 human NuMA-1 4926 Q14980 NUMA1 human T1812 477991 RsARRRttQIINItM X +AURKA AurA O14965 human BIM 10018 O43521 BCL2L11 human S93 8080215 SsLLSRSssGyFsFD X X +AURKA AurA O14965 human BAP37 11331 Q99623 PHB2 human S39 1868188300 VAyGVREsVFTVEGG X +AURKA AurA O14965 human PIN1 5300 Q13526 PIN1 human S16 447772 PGWEkRMsRSSGRVy WW X X +AURKA AurA O14965 human AKIP 54998 Q9NWT8 AURKAIP1 human S70 999611 MLVPRKMsVSPLESW X X +AURKA AurA O14965 human AurA 6790 O14965 AURKA human S342 457608 QETYKRIsRVEFTFP Pkinase X +AURKA AurA O14965 human BIM 10018 O43521 BCL2L11 human S94 4698178 sLLSRSssGyFsFDT X X +AURKA AurA O14965 human AurA 6790 O14965 AURKA human S104 457667 KskQPLPsAPENNPE X +AURKA AurA O14965 human NuMA-1 4926 Q14980 NUMA1 human S1969 3196643 QEtLRRAsMQPIQIA X +AURKA AurA O14965 human TPX2 398174 Q6NUF4 tpx2.L frog S94 1869508032 KRSsRRMsKKHRQKL X +AURKA AurA O14965 human NuMA-1 4926 Q14980 NUMA1 human T1804 3196649 FLDsGrKtRsARRRt X +AURKA AurA O14965 human SOX8 30812 P57073 SOX8 human S327 4715062 SAPSASAsPTETGPP X X +AURKA AurA O14965 human WDR62 284403 O43379 WDR62 human S32 10989988 VPARRGQssPPPAPP X +AURKA AurA O14965 human KIBRA 23286 Q8IX03 WWC1 human S539 20751200 tsLsPRSsLSsPSPP X X +AURKA AurA O14965 human AR 367 P10275 AR human T282 15605002 VPPAVRPtPCAPLAE Androgen_recep X X +AURKA AurA O14965 human DLG7 9787 Q15398 DLGAP5 human S757 456347 EGMELNSsItSQDVL X +AURKA AurA O14965 human MBD3 53615 O95983 MBD3 human S24 11378200 REEVPRRsGLSAGHR MBD X X +AURKA AurA O14965 human TIFA 92610 Q96CG3 TIFA human T9 50409900 tSFEDADtEEtVTCL X X +AURKA AurA O14965 human FANCA 2175 O15360 FANCA human S165 56757905 HSMFSRLsFCQELWK X X +AURKA AurA O14965 human p53 7157 P04637 TP53 human S215 454242 DrNtFrHsVVVPyEP P53 X X +AURKA AurA O14965 human HEC1 10403 O14777 NDC80 human S69 474513 sGHGsRNsQLGIFss Ndc80_HEC X X +AURKA AurA O14965 human TPX2 22974 Q9ULW0 TPX2 human S125 459997 QRRsLRLsAQkDLEQ X X +AURKA AurA O14965 human LIMK1 3984 P53667 LIMK1 human T508 447808 PDRKKRYtVVGNPYW PK_Tyr_Ser-Thr X X 3841 +AURKA AurA O14965 human NuMA-1 4926 Q14980 NUMA1 human S2087 28722901 tRSGtRRsPRIATTT X +AURKA AurA O14965 human AurA 6790 O14965 AURKA human S83 457665 QKQLQATsVPHPVsR X +AURKA AurA O14965 human NUSAP1 51203 Q9BXS6 NUSAP1 human S240 469451 VPPRGRLsVAstPIs NUSAP X +AURKA AurA O14965 human AurA 6790 O14965 AURKA human S391 457671 TANSSKPsNCQNKES X +AURKA AurA O14965 human hnRNP K 3190 P61978 HNRNPK human S379 483629 syAGGrGsyGDLGGP X X +AURKA AurA O14965 human TACC3 21335 Q9JJ11 Tacc3 mouse S347 474537 ESAWRKQsLyVKFDP X +AURKA AurA O14965 human AurA 6790 O14965 AURKA human T288 448784 APSsRRttLCGtLDy Pkinase X X 3079; 2914; 13464; 8525 +AURKA AurA O14965 human LIMK1 3984 P53667 LIMK1 human S307 3191869 DRsPGAGsLGsPAsQ X X +AURKA AurA O14965 human CENPA 1058 P49450 CENPA human S7 448601 _MGPRRRsRKPEAPR Histone X 2187 +AURKA AurA O14965 human RASSF1 iso2 11186 Q9NS23-2 RASSF1 human S203 484000 TsVRRRtsFYLPKDA RA X X +AURKA AurA O14965 human ER-alpha 2099 P03372 ESR1 human S305 448805 IkRSkkNsLALSLtA X X +AURKA AurA O14965 human LIMK2 3985 P53671 LIMK2 human S283 456167 EGtLRRRsLRRsNsI X X +AURKA AurA O14965 human MCM2 4171 P49736 MCM2 human S220 2201403 NVFkERIsDMCkENR MCM_N X +AURKA AurA O14965 human IkB-alpha 4792 P25963 NFKBIA human S32 448203 LLDDRHDsGLDsMkD X 5210; 2859; 9246; 5209 +AURKA AurA O14965 human AR 367 P10275 AR human S293 15605001 PLAECKGsLLDDsAG Androgen_recep X X +AURKA AurA O14965 human KIF2C 380006 Q91636 kif2c frog S196 2132102 NNQGRRKsNIVKEME X +AURKA AurA O14965 human PKM 5315 P14618 PKM human T45 476071 PPItARNtGIICtIG PK X X +AURKA AurA O14965 human ALDH1A1 216 P00352 ALDH1A1 human T267 14567868 KSNLKRVtLELGGKS Aldedh X X +AURKA AurA O14965 human p53 7157 P04637 TP53 human S315 447530 LPNNtsssPQPkkkP X X 2528 +AURKA AurA O14965 human Geminin 51053 O75496 GMNN human T25 40323301 NSSVPRRtLkMIQPS Geminin X X +AURKA AurA O14965 human KCTD12 115207 Q96CX2 KCTD12 human S200 468044 PLLtPsQsLDGsRRs X +AURKA AurA O14965 human RALA 5898 P11233 RALA human S194 483989 NGKKKRKsLAKRIRE X +AURKA AurA O14965 human RASSF1 iso2 11186 Q9NS23-2 RASSF1 human T202 483999 GTsVRRRtsFYLPKD RA X X +AURKA AurA O14965 human TACC3 10460 Q9Y6A5 TACC3 human S558 474537 ESALRKQsLyLkFDP X X 8842; 5645 +AURKA AurA O14965 human NuMA-1 4926 Q14980 NUMA1 human S1991 487347 RQQRkRVsLEPHQGP X +AURKA AurA O14965 human YY1 7528 P25490 YY1 human S365 15416769 EGCGkRFsLDFNLRT zf-C2H2 X X +AURKA AurA O14965 human CDC25B 994 P30305 CDC25B human S353 452008 VQNkRRRsVtPPEEQ M-inducer_phosp X X +Ikbkb IKKB Q9QY78 rat IkB-alpha 25493 Q63746 Nfkbia rat S32 448203 LVDDRHDsGLDsMKD X 5210; 2859; 9246; 5209 +Ikbkb IKKB Q9QY78 rat SNAP23 64630 O70377 Snap23 rat S120 455263 NVVsKQPsRITNGQP SNAP-25 X +Ikbkb IKKB Q9QY78 rat CARD11 416476 Q5F3W0 RCJMB04_5k17 chicken S578 457640 NRNDSIMsTTPEPPG X +Ikbkb IKKB Q9QY78 rat SNAP23 8773 O00161 SNAP23 human S95 455262 NRTkNFEsGkAykTt SNAP-25 X +Ikbkb IKKB Q9QY78 rat IkB-alpha 25493 Q63746 Nfkbia rat S36 448204 RHDsGLDsMKDEDyE X 5210; 9246 +Ikbkb IKKB Q9QY78 rat SNAP23 64630 O70377 Snap23 rat S95 455262 NRTKNFEsGKNYKAt SNAP-25 X +Stk10 LOK O55098 mouse Moesin 17698 P26041 Msn mouse T558 447706 LGRDKYKtLRQIRQG ERM_C X 3141; 3726; 32600 +GTF2F1 GTF2F1 P35269 human GTF2F1 2962 P35269 GTF2F1 human S385 483594 GGssRGNsRPGtPsA TFIIF_alpha X +GTF2F1 GTF2F1 P35269 human RARG 5916 P13631 RARG human S79 455544 EMVPSsPsPPPPPRV X +GTF2F1 GTF2F1 P35269 human RARG 5916 P13631 RARG human S77 455543 SEEMVPSsPsPPPPP X +GTF2F1 GTF2F1 P35269 human GTF2F1 2962 P35269 GTF2F1 human T389 483595 RGNsRPGtPsAEGGs TFIIF_alpha X +LATS1 LATS1 O95835 human INCENP 3619 Q9NQS7 INCENP human S894 450468 RYHKRtssAVWNsPP X +LATS1 LATS1 O95835 human CDK8 264064 Q8R3L8 Cdk8 mouse S62 1876860402 EGTGISMsACREIAL Pkinase X X +LATS1 LATS1 O95835 human YAP1 10413 P46937 YAP1 human S397 3190672 tyHSRDEstDsGLsM X X +LATS1 LATS1 O95835 human YAP1 10413 P46937 YAP1 human S61 484116 IVHVRGDsEtDLEAL X 75784; 86312 +LATS1 LATS1 O95835 human YAP1 22601 P46938 Yap1 mouse S112 448847 PQHVRAHssPAsLQL X X 4911; 13008; 92367; 57706 +LATS1 LATS1 O95835 human MLK3 4296 Q16584 MAP3K11 human T477 36324901 HVRRRRGtFKRSKLR X X +LATS1 LATS1 O95835 human SASH1 23328 O94885 SASH1 human S407 468680 LSHGRtCsFGGFDLT SLY X +LATS1 LATS1 O95835 human CDC26 246184 Q8NHZ8 CDC26 human T7 10815632 _MLRRKPtRLELKLD ANAPC_CDC26 X X +LATS1 LATS1 O95835 human YAP1 22601 P46938 Yap1 mouse S382 3190672 TyHSRDEstDsGLSM X 13619 +LATS1 LATS1 O95835 human Raptor 57521 Q8N122 RPTOR human S606 53407301 SAHEkLYsLLSDPIP HEAT X X +LATS1 LATS1 O95835 human Snail2 6591 O43623 SNAI2 human T208 25311911 QGHIRtHtGEkPFSC X X +LATS1 LATS1 O95835 human LATS1 9113 O95835 LATS1 human S674 481736 EMMRVGLsQDAQDQM X +LATS1 LATS1 O95835 human LATS1 9113 O95835 LATS1 human S909 457594 HQRCLAHsLVGTPNY Pkinase X 9157 +LATS1 LATS1 O95835 human YAP1 10413 P46937 YAP1 human S381 3190669 LRTMTTNssDPFLNs X +LATS1 LATS1 O95835 human YAP1 iso2 10413 P46937-2 YAP1 human S61 484116 IVHVRGDsEtDLEAL X +LATS1 LATS1 O95835 human MTF1 4520 Q14872 MTF1 human S152 50784002 EGCPRTysTAGNLRT zf-C2H2 X X +LATS1 LATS1 O95835 human PRPS1 5631 P60891 PRPS1 human S285 1874748500 EDkMKHCsKIQVIDI Pribosyl_synth X X +LATS1 LATS1 O95835 human MTF1 17764 Q07243 Mtf1 mouse S151 50784002 EGCPRtYsTAGNLRT zf-C2H2 X +LATS1 LATS1 O95835 human RAF1 5894 P04049 RAF1 human S259 447741 sQRQRststPNVHMV X 9421; 20011 +LATS1 LATS1 O95835 human KIF23 9493 Q02241 KIF23 human S814 470674 LRHRRsRsAGDRWVD MKLP1_Arf_bdg X X +LATS1 LATS1 O95835 human AMOT 154796 Q4VCS5 AMOT human S175 28699604 QGHVRSLsERLMQMS X +LATS1 LATS1 O95835 human YAP1 iso2 10413 P46937-2 YAP1 human S109 452305 KsHsRQAstDAGtAG X 46931; 53749 +LATS1 LATS1 O95835 human KIF23 9493 Q02241 KIF23 human S716 453934 QLHRRsNsCsSISVA X X +LATS1 LATS1 O95835 human YAP1 10413 P46937 YAP1 human S127 448847 PQHVRAHssPAsLQL X X 4911; 13008; 92367; 57706 +LATS1 LATS1 O95835 human LATS1 9113 O95835 LATS1 human S1049 1791602 VDPDkLWsDDNEEEN X +LATS1 LATS1 O95835 human PRPS2 5634 P11908 PRPS2 human T285 1874748502 EDkMkHCtKIQVIDI Pribosyl_synth X X +LATS1 LATS1 O95835 human YAP1 iso2 10413 P46937-2 YAP1 human S127 448847 PQHVRAHssPASLQL X X 57706 +LATS1 LATS1 O95835 human YAP1 10413 P46937 YAP1 human S109 452305 ksHsRQAstDAGtAG X 46931; 53749 +LATS1 LATS1 O95835 human YAP1 iso2 10413 P46937-2 YAP1 human S164 471933 AQHLRQssFEIPDDV X +LATS1 LATS1 O95835 human YAP1 iso2 10413 P46937-2 YAP1 human S381 3190672 TYHSRDEsTDsGLsM X 13619 +LATS1 LATS1 O95835 human TAZ 25937 Q9GZV5 WWTR1 human S89 457660 AQHVRsHssPAsLQL X 75275; 59971 +Stk17b DRAK2 Q8BG48 mouse DRAK2 98267 Q8BG48 Stk17b mouse S12 1851300 RFDCRsVsGLLTTTP X +Stk17b DRAK2 Q8BG48 mouse DRAK2 98267 Q8BG48 Stk17b mouse S351 1735800 PEDGsLVsKRFRFDD X +Stk17b DRAK2 Q8BG48 mouse DRAK2 98267 Q8BG48 Stk17b mouse S362 2627602 RFDDSLPsPHELVPD X +Stk17b DRAK2 Q8BG48 mouse DRAK2 98267 Q8BG48 Stk17b mouse S328 2627603 SEEKTSKsSCNGsCG X +Stk17b DRAK2 Q8BG48 mouse DRAK2 98267 Q8BG48 Stk17b mouse S348 1851301 ENIPEDGsLVsKRFR X +Stk17b DRAK2 Q8BG48 mouse DRAK2 98267 Q8BG48 Stk17b mouse S333 2627601 SKsSCNGsCGAREDK X +Stk17b DRAK2 Q8BG48 mouse DRAK2 98267 Q8BG48 Stk17b mouse S10 2627600 RRRFDCRsVsGLLTT X +Itk ITK Q03526 mouse TBX21 57765 Q9JKD8 Tbx21 mouse Y525 458297 KETEGQFyNYFPN__ X +Itk ITK Q03526 mouse ITK 16428 Q03526 Itk mouse Y186 449834 ETLVIALyDYQTNDP SH3_1 X +PDGFRB PDGFRB P09619 human PDGFRB 5159 P09619 PDGFRB human Y1021 447523 PNEGDNDyIIPLPDP X X 2227 +PDGFRB PDGFRB P09619 human PDGFRA 5156 P16234 PDGFRA human Y754 448439 ERKEVsKysDIQRsL PK_Tyr_Ser-Thr X 2992 +PDGFRB PDGFRB P09619 human PDGFRB 5159 P09619 PDGFRB human Y1009 447522 LDTSSVLyTAVQPNE X X 3124 +PDGFRB PDGFRB P09619 human FAK 5747 Q05397 PTK2 human Y5 7445815 ___MAAAyLDPNLNH X X +PDGFRB PDGFRB P09619 human Arg 27 P42684 ABL2 human Y272 456540 KCNKPTVyGVsPIHD X +PDGFRB PDGFRB P09619 human PDGFRB 5159 P09619 PDGFRB human Y579 447521 VSSDGHEyIyVDPMQ X +PDGFRB PDGFRB P09619 human PDGFRB 5159 P09619 PDGFRB human Y562 458338 LWQKKPRyEIRWKVI X +PDGFRB PDGFRB P09619 human FMIP 8563 Q13769 THOC5 human Y225 25802102 EIEVKKEyLSSLQPR FmiP_Thoc5 X +PDGFRB PDGFRB P09619 human Arg 27 P42684 ABL2 human Y139 7437800 EKLRVLGyNQNGEWS SH3_1 X +PDGFRB PDGFRB P09619 human PLCG1 5335 P19174 PLCG1 human Y783 447667 EGRNPGFyVEANPMP X 2821; 14461; 14008; 25678; 88717 +PDGFRB PDGFRB P09619 human PDGFRB 5159 P09619 PDGFRB human Y740 447520 TGESDGGyMDMSKDE PK_Tyr_Ser-Thr X 3168 +PDGFRB PDGFRB P09619 human Arg 27 P42684 ABL2 human Y439 447923 RLMtGDtytAHAGAk PK_Tyr_Ser-Thr X +PDGFRB PDGFRB P09619 human Fyn 2534 P06241 FYN human Y28 447879 sLNQssGyRyGTDPT X +PDGFRB PDGFRB P09619 human Tel 2120 P41212 ETV6 human Y17 454812 IkQERIsytPPEsPV X X +PDGFRB PDGFRB P09619 human FAK 5747 Q05397 PTK2 human Y194 18122800 ALEKKSNyEVLEkDV FERM_M X X +PDGFRB PDGFRB P09619 human PDGFRB 5159 P09619 PDGFRB human Y763 448850 DMKGDVKyADIESSN PK_Tyr_Ser-Thr X +PDGFRB PDGFRB P09619 human Ack 10188 Q07912 TNK2 human Y635 4251154 PLPPPPAyDDVAQDE X X +PDGFRB PDGFRB P09619 human PDGFRB 5159 P09619 PDGFRB human Y581 447519 SDGHEyIyVDPMQLP X +PDGFRB PDGFRB P09619 human Arg 27 P42684 ABL2 human Y116 2226537 PNLFVALyDFVAsGD SH3_1 X +PDGFRB PDGFRB P09619 human Arg 27 P42684 ABL2 human Y303 456543 GGQyGEVyVGVWKKy PK_Tyr_Ser-Thr X +PDGFRB PDGFRB P09619 human MUC1 4582 P15941 MUC1 human Y1218 473759 tyHtHGRyVPPsstD X +PDGFRB PDGFRB P09619 human Arg 27 P42684 ABL2 human Y310 456544 yVGVWKKysLtVAVK PK_Tyr_Ser-Thr X +PDGFRB PDGFRB P09619 human PDGFRB 5159 P09619 PDGFRB human Y857 447509 DIMRDSNyISKGSTF PK_Tyr_Ser-Thr X X 3170 +PDGFRB PDGFRB P09619 human PDGFRB 5159 P09619 PDGFRB human Y775 449964 SSNyMAPyDNyVPSA PK_Tyr_Ser-Thr X +PDGFRB PDGFRB P09619 human MUC1 4582 P15941 MUC1 human Y1203 454878 IFPARDtyHPMsEyP X +PDGFRB PDGFRB P09619 human PDGFRB 5159 P09619 PDGFRB human Y771 447517 ADIESSNyMAPyDNy PK_Tyr_Ser-Thr X X 3173 +PDGFRB PDGFRB P09619 human Arg 27 P42684 ABL2 human Y161 449482 QGWVPsNyItPVNSL X +PDGFRB PDGFRB P09619 human Tel 2120 P41212 ETV6 human Y27 454813 PEsPVPsyAsstPLH X X +PDGFRB PDGFRB P09619 human Src 6714 P12931 SRC human Y419 448234 RLIEDNEytARQGAk PK_Tyr_Ser-Thr X 2101; 6943; 59548; 70926; 78740; 94361; 17320 +PDGFRB PDGFRB P09619 human PDGFRB 5159 P09619 PDGFRB human Y751 447508 SKDESVDyVPMLDMK PK_Tyr_Ser-Thr X X 3166; 3161; 4549 +PDGFRB PDGFRB P09619 human Arg 27 P42684 ABL2 human Y299 3973063 HKLGGGQyGEVyVGV PK_Tyr_Ser-Thr X +PDGFRB PDGFRB P09619 human PDGFRB 5159 P09619 PDGFRB human Y778 450207 yMAPyDNyVPSAPER PK_Tyr_Ser-Thr X +Vrk1 VRK1 Q80X41 mouse coilin 8161 P38432 COIL human S184 11329300 NEEAKRKsPKKKEKC Coilin_N X +PHKB PHKB P12798 rabbit PHKB 100009137 P12798 PHKB rabbit S12 470137 TGLMAEVsWKVLERR X +PHKB PHKB P12798 rabbit PHKB 100009137 P12798 PHKB rabbit S700 472411 HSKVKRQsSTSNAPE Glyco_hydro_15 X +PHKB PHKB P12798 rabbit PHKB 100009137 P12798 PHKB rabbit S27 470138 ARTKRSGsVYEPLKS X +CDK7 CDK7 P50613 human CDK11B 984 P21127 CDK11B human T595 449142 GsPLKAytPVVVtLW Pkinase X +CDK7 CDK7 P50613 human Rb 5925 P06400 RB1 human S780 447978 strPPtLsPIPHIPr Rb_C X 9307; 3590; 8180 +CDK7 CDK7 P50613 human MCM2 4171 P49736 MCM2 human S5 2201405 ___MAEssEsFtMAs X +CDK7 CDK7 P50613 human Oct4 5460 Q01860 POU5F1 human S12 18496900 LASDFAFsPPPGGGG X +CDK7 CDK7 P50613 human CDK2 1017 P24941 CDK2 human Y168 4319901 HEVVtLWyRAPEILL Pkinase X +CDK7 CDK7 P50613 human ER-alpha 2099 P03372 ESR1 human S118 448101 LHPPPQLsPFLQPHG Oest_recep X X 2511 +CDK7 CDK7 P50613 human CDK6 1021 Q00534 CDK6 human T177 2454600 YSFQMALtSVVVTLW Pkinase X +CDK7 CDK7 P50613 human OGFOD1 55239 Q8N543 OGFOD1 human S256 1874115106 FEPPIPRsPHIPQDH X X +CDK7 CDK7 P50613 human ICK 56542 Q9JKV2 Cilk1 mouse T157 456051 IRSRPPytDyVStRW Pkinase X X +CDK7 CDK7 P50613 human p53 7157 P04637 TP53 human S371 447533 AHssHLkskkGQsts X +CDK7 CDK7 P50613 human SPT5 6829 O00267 SUPT5H human T784 458816 MyGsGsrtPMyGsQt X +CDK7 CDK7 P50613 human MCM2 4171 P49736 MCM2 human S41 452312 RtDALtssPGRDLPP X X +CDK7 CDK7 P50613 human CDK9 1025 P50750 CDK9 human S175 456536 FGLARAFsLAkNSQP Pkinase X X +CDK7 CDK7 P50613 human POLR2A 5430 P24928 POLR2A human S1616 450204 TPQSPSysPtsPsYS RNA_pol_Rpb1_R X X 4735; 13499; 13546; 31262 +CDK7 CDK7 P50613 human MED1 5469 Q15648 MED1 human T1457 449866 HsKsPAytPQNLDsE X X +CDK7 CDK7 P50613 human Oct4 18999 P20263 Pou5f1 mouse S12 18496900 LASDFAFsPPPGGGD X +CDK7 CDK7 P50613 human MCM2 4171 P49736 MCM2 human S13 473057 EsFtMAssPAQRRRG X +CDK7 CDK7 P50613 human RARA 5914 P10276 RARA human S77 455459 EIVPsPPsPPPLPRI X X +CDK7 CDK7 P50613 human XRN2 22803 Q9H0D6 XRN2 human T439 3211959 FtPsGILtPHALGsR XRN_M X +CDK7 CDK7 P50613 human p53 7157 P04637 TP53 human S376 447570 LkskkGQstsRHkkL X +CDK7 CDK7 P50613 human E2F1 1869 Q01094 E2F1 human T433 447871 DCDFGDLtPLDF___ X X +CDK7 CDK7 P50613 human RARA 19401 P11416 Rara mouse S77 455459 EIVPSPPsPPPLPRI X X +CDK7 CDK7 P50613 human SPT5 6829 O00267 SUPT5H human T775 458815 tPMyGsQtPMyGsGs X +CDK7 CDK7 P50613 human SPT5 6829 O00267 SUPT5H human S782 4948434 tPMyGsGsrtPMyGs X +CDK7 CDK7 P50613 human STF-1 26423 P33242 Nr5a1 mouse S203 447603 EYPEPYAsPPQQPGP X +CDK7 CDK7 P50613 human POLR2A 20020 P08775 Polr2a mouse S1619 447616 SPSYsPtsPSYSPTS RNA_pol_Rpb1_R X 4735; 13523; 13546; 67221 +CDK7 CDK7 P50613 human CDK2 1017 P24941 CDK2 human T160 447739 GVPVRtytHEVVtLW Pkinase X 2561 +CDK7 CDK7 P50613 human SPT5 6829 O00267 SUPT5H human S773 15415344 GRtPMyGsQtPMyGs X +CDK7 CDK7 P50613 human POLR2A 5430 P24928 POLR2A human S1621 3439802 SysPtsPsYSPTSPS RNA_pol_Rpb1_R X 13780 +CDK7 CDK7 P50613 human CDK4 1019 P11802 CDK4 human T172 448476 YSYQMALtPVVVTLW Pkinase X +CDK7 CDK7 P50613 human p53 7157 P04637 TP53 human S378 447534 skkGQstsRHkkLMF X +CDK7 CDK7 P50613 human SMAD1 4086 Q15797 SMAD1 human S206 451175 SSStYPHsPTSSDPG X 9553; 5753 +CDK7 CDK7 P50613 human CDK1 983 P06493 CDK1 human T161 447609 GIPIRVytHEVVTLW Pkinase X X 9114 +CDK7 CDK7 P50613 human MCM2 4171 P49736 MCM2 human S4 2201407 ____MAEssEsFtMA X +CDK7 CDK7 P50613 human p53 7157 P04637 TP53 human S392 447535 FktEGPDsD______ X 9281 +CDK7 CDK7 P50613 human MBLR 84108 Q9BYE7 PCGF6 human S30 455506 LPPPPPVsPPALTPA X +CDK7 CDK7 P50613 human FMR1 14265 P35922 Fmr1 mouse S499 469583 NSEAsNAsETESDHR FXMRP1_C_core X +CDK7 CDK7 P50613 human p53 7157 P04637 TP53 human S33 447531 LPENNVLsPLPsQAM X 2526 +CDK7 CDK7 P50613 human POLR2A 5430 P24928 POLR2A human S1619 447616 SPSysPtsPsYSPTS RNA_pol_Rpb1_R X X 4735; 13523; 13546; 67221 +CDK7 CDK7 P50613 human MCM2 4171 P49736 MCM2 human S108 456310 DVEELtAsQREAAER MCM2_N X +CDK7 CDK7 P50613 human XPB 2071 P19447 ERCC3 human S90 1867858202 HIFLEAFsPVYKYAQ Helicase_C_3 X +CDK7 CDK7 P50613 human RARG 5916 P13631 RARG human S79 455544 EMVPSsPsPPPPPRV X +CDK7 CDK7 P50613 human CDK12 51755 Q9NYV4 CDK12 human T893 472551 sEEsRPytNKVITLW Pkinase X +CDK7 CDK7 P50613 human Rb 5925 P06400 RB1 human S807 447980 PGGNIyIsPLksPyk Rb_C X 9308; 8974; 4277; 40283; 8957; 8516; 11917; 99274; 41359; 75864; 72443 +CDK7 CDK7 P50613 human MCM2 4171 P49736 MCM2 human S40 452311 RRtDALtssPGRDLP X +CDK7 CDK7 P50613 human MCM2 4171 P49736 MCM2 human T59 2201408 EsEGLLGtEGPLEEE MCM2_N X +CDK7 CDK7 P50613 human MCM2 4171 P49736 MCM2 human S53 473058 LPPFEDEsEGLLGtE MCM2_N X +CDK7 CDK7 P50613 human MCM2 4171 P49736 MCM2 human S139 454180 RRGLLyDsDEEDEER MCM2_N X X 8861; 12958 +CDK7 CDK7 P50613 human E2F1 1869 Q01094 E2F1 human S403 447870 PEEFISLsPPHEALD X X +CDK7 CDK7 P50613 human Rb 5925 P06400 RB1 human S811 448717 IyIsPLksPykIsEG Rb_C X 9308; 8974; 4277; 40283; 8957; 8516; 11917; 41359; 75864; 63276 +CDK7 CDK7 P50613 human RARG 5916 P13631 RARG human S77 455543 SEEMVPSsPsPPPPP X +CDK7 CDK7 P50613 human GRP78 3309 P11021 HSPA5 human T69 55370298 tPsyVAFtPEGERLI HSP70 X X +CDK7 CDK7 P50613 human MCM2 4171 P49736 MCM2 human S27 452310 GNDPLtssPGRssRR X X +CDK7 CDK7 P50613 human CDK2 1017 P24941 CDK2 human S46 4271962 tETEGVPsTAIREIS Pkinase X +CDK7 CDK7 P50613 human CDK2 1017 P24941 CDK2 human T165 4319900 tytHEVVtLWyRAPE Pkinase X +CDK7 CDK7 P50613 human RARA 19401 P11416 Rara mouse S461 455330 RSsPATQsP______ X +CDK7 CDK7 P50613 human POLR2A 5430 P24928 POLR2A human S1878 3182204 sPKysPtsPtysPtt RNA_pol_Rpb1_R X +CDK7 CDK7 P50613 human MCM2 4171 P49736 MCM2 human S7 2201406 _MAEssEsFtMAssP X +CDK7 CDK7 P50613 human AR 367 P10275 AR human S516 452166 VSRVPYPsPTCVkSE X +CDK7 CDK7 P50613 human STF-1 2516 Q13285 NR5A1 human S203 447603 EYPEPYAsPPQPGLP X X +FGFR4 FGFR4 P22455 human FGFR4 2264 P22455 FGFR4 human Y754 448027 LLAVSEEyLDLRLTF X +FGFR4 FGFR4 P22455 human MST1 6789 Q13043 STK4 human Y433 463558 kIPQDGDyEFLksWt Mst1_SARAH X X +FGFR4 FGFR4 P22455 human GLO1 2739 Q04760 GLO1 human Y136 463450 GIAVPDVysACkRFE Glyoxalase X +Lats1 LATS1 F1M2K4 rat AMOT 154796 Q4VCS5 AMOT human S175 28699604 QGHVRSLsERLMQMS X +Ripk1 RIPK1 Q60855 mouse DRP1 74006 Q8K1M6 Dnm1l mouse S622 454690 PIPIMPAsPQKGHAV X 3455; 4494; 63940 +Ripk1 RIPK1 Q60855 mouse RIPK1 19766 Q60855 Ripk1 mouse S166 27116401 VAsFKTWsKLtKEKD PK_Tyr_Ser-Thr X 31122; 53286 +Mapk8 JNK1 P49185 rat Doublecortin iso2 1641 O43602-2 DCX human T331 469976 SKQsPIStPTsPGSL X +Mapk8 JNK1 P49185 rat STMN1 29332 P13668 Stmn1 rat S38 448556 SVPEFPLsPPKKkDL Stathmin X 3426; 4191 +Mapk8 JNK1 P49185 rat PSD-95 29495 P31016 Dlg4 rat S295 456936 PTsPRRYsPVAKDLL PDZ_assoc X 45737 +Mapk8 JNK1 P49185 rat GR 24413 P06536 Nr3c1 rat S246 451796 LIDENLLsPLAGEDD GCR X X 97285 +Mapk8 JNK1 P49185 rat IRS1 16367 P35569 Irs1 mouse S307 447558 tEsITAtsPAsMVGG X 2381 +Mapk8 JNK1 P49185 rat CTNND2 114028 NP_001258431 Ctnnd2 rat S444 480954 RTSTAPSsPGVDSVP X +Mapk8 JNK1 P49185 rat STMN1 29332 P13668 Stmn1 rat S25 448555 QAFELILsPRSKESV Stathmin X +Mapk8 JNK1 P49185 rat Jun 24516 P17325 Jun rat S73 447943 VGLLKLAsPELERLI Jun X 9164; 3270; 8752; 12714; 77955 +Mapk8 JNK1 P49185 rat MAP2 25595 P15146 Map2 rat T1622 450181 YSSRtPGtPGtPSyP X 4544 +Mapk8 JNK1 P49185 rat MAP2 25595 P15146 Map2 rat T1619 4704347 PPsYSSRtPGtPGtP X +Mapk8 JNK1 P49185 rat Doublecortin iso2 1641 O43602-2 DCX human T321 451361 TSSSQLStPKSKQsP X +Mapk8 JNK1 P49185 rat IRS1 25467 P35570 Irs1 rat S307 447558 TEsITATsPASMVGG X 2381 +Mapk8 JNK1 P49185 rat Doublecortin iso2 1641 O43602-2 DCX human S334 451359 sPIStPTsPGSLRkH X 3453; 14053 +Mapk8 JNK1 P49185 rat MAP2 25595 P15146 Map2 rat T1625 450182 RtPGtPGtPSyPRTP X 4544 +Mapk8 JNK1 P49185 rat IRS2 29376 F1MAL5 Irs2 rat T348 483924 RTDsLAAtPPAAKCT X +DYRK4 DYRK4 Q9NR20 human DYRK4 8798 Q9NR20 DYRK4 human Y264 454665 EHQKVytyIQsRFYR Pkinase X +Ptk2 FAK iso2 P34152-2 mouse FAK 14083 P34152 Ptk2 mouse Y397 447887 sVsEtDDyAEIIDEE X X 3283; 8556 +Ptk2 FAK iso2 P34152-2 mouse SHC1 iso2 6464 P29353-2 SHC1 human Y317 448511 ELFDDPSyVNVQNLD X +Ptk2 FAK iso2 P34152-2 mouse Cortactin 13043 Q60598 Cttn mouse Y421 447702 RPPssPIyEDAAPFK X 4569 +Ptk2 FAK iso2 P34152-2 mouse N-WASP 73178 Q91YD9 Wasl mouse Y253 450253 RETSKVIyDFIEKTG PBD X X +Ptk2 FAK iso2 P34152-2 mouse FAK iso2 14083 P34152-2 Ptk2 mouse Y428 447887 SGDETDDyAEIIDEE X 3283; 8556 +Ptk2 FAK iso2 P34152-2 mouse Cortactin 13043 Q60598 Cttn mouse Y466 447703 TyTSEPVyETTEAPG X +Ptk2 FAK iso2 P34152-2 mouse ARHGEF7 8874 Q14155 ARHGEF7 human Y620 3753309 PAPLtPAyHTLPHPS X +Ptk2 FAK iso2 P34152-2 mouse P130Cas 12927 Q61140 Bcar1 mouse Y668 448399 EGGWMEDyDyVHLQG CAS_C X +Ptk2 FAK iso2 P34152-2 mouse Cortactin 13043 Q60598 Cttn mouse Y482 447704 yQAEDDTyDGYESDL X +Egfr EGFR Q01279 mouse EGFR 13649 Q01279 Egfr mouse Y1197 448060 PTAENAEyLRVAPPS X 2244; 4407; 47737 +Egfr EGFR Q01279 mouse EPS15 13858 P42567 Eps15 mouse Y850 450484 NFANFSAyPsEEDMI X +Egfr EGFR Q01279 mouse GAB1 14388 Q9QYY0 Gab1 mouse Y448 449791 GEELDENyVPMNPNs X +Egfr EGFR Q01279 mouse PIP5K1C 18717 O70161 Pip5k1c mouse Y634 486321 DAPSTDIyFPTDERS X +Egfr EGFR Q01279 mouse GAB1 14388 Q9QYY0 Gab1 mouse Y407 447946 DASsQDCyDIPRtFP X +Egfr EGFR Q01279 mouse GAB1 14388 Q9QYY0 Gab1 mouse Y590 449792 SHDSEENyVPMNPNL X +Egfr EGFR Q01279 mouse hnRNP P2 233908 P56959 Fus mouse Y6 1869633701 __MASNDyTQQATQS X +Egfr EGFR Q01279 mouse GAB1 14388 Q9QYY0 Gab1 mouse Y628 447948 KGDKQVEyLDLDLDs X 3231; 3233 +Egfr EGFR Q01279 mouse GAB1 14388 Q9QYY0 Gab1 mouse Y473 447947 EPIQEPNyVPMtPGT X +Egfr EGFR Q01279 mouse GAB1 14388 Q9QYY0 Gab1 mouse Y660 447949 MADERVDyVVVDQQK X 12745 +Egfr EGFR Q01279 mouse PKACA 18747 P05132 Prkaca mouse Y331 15230353 DTSNFDDyEEEEIRV X +Egfr EGFR Q01279 mouse PLD2 18806 P97813 Pld2 mouse Y11 450938 TQKNLFPyGDyLNSS X +Egfr EGFR Q01279 mouse GAB1 14388 Q9QYY0 Gab1 mouse Y373 447945 ASDtDSSyCIPPPAG X +Egfr EGFR Q01279 mouse GAB1 14388 Q9QYY0 Gab1 mouse Y285 449801 TEADGELyTFNTPSG X +Egfr EGFR Q01279 mouse ZNRF1 170737 Q91V17 Znrf1 mouse Y103 479016 TyAHGNGyQETGGGH X +Egfr EGFR Q01279 mouse CBL 867 P22681 CBL human Y371 449753 TQEQyELyCEMGSTF X +Egfr EGFR Q01279 mouse hnRNP P2 233908 P56959 Fus mouse Y297 1869633700 TIESVADyFKQIGII RRM_1 X +Egfr EGFR Q01279 mouse GAB1 14388 Q9QYY0 Gab1 mouse Y307 447944 MRHVsISyDIPPtPG X 3234 +Egfr EGFR Q01279 mouse EGFR 13649 Q01279 Egfr mouse Y1069 448056 EDAFLQRyssDPtGA X +STK38 NDR1 Q15208 human YAP1 10413 P46937 YAP1 human S61 484116 IVHVRGDsEtDLEAL X 75784; 86312 +STK38 NDR1 Q15208 human YAP1 10413 P46937 YAP1 human S164 471933 AQHLRQssFEIPDDV X +STK38 NDR1 Q15208 human Exportin-1 7514 O14980 XPO1 human S1055 453528 EKHKRQMsVPGIFNP X +STK38 NDR1 Q15208 human NDR1 11329 Q15208 STK38 human T444 460659 DWVFINytyKRFEGL Pkinase_C X X +STK38 NDR1 Q15208 human RAB3IP 117177 Q96QF0 RAB3IP human S288 4734219 KGHTRNKstSSAMSG X +STK38 NDR1 Q15208 human KIF23 9493 Q02241 KIF23 human S814 470674 LRHRRsRsAGDRWVD MKLP1_Arf_bdg X +STK38 NDR1 Q15208 human KIF23 9493 Q02241 KIF23 human S716 453934 QLHRRsNsCsSISVA X +STK38 NDR1 Q15208 human YAP1 10413 P46937 YAP1 human S127 448847 PQHVRAHssPAsLQL X X 4911; 13008; 92367; 57706 +STK38 NDR1 Q15208 human NDR1 11329 Q15208 STK38 human S281 448828 NRRQLAFstVGtPDy Pkinase X X +STK38 NDR1 Q15208 human YAP1 10413 P46937 YAP1 human S109 452305 ksHsRQAstDAGtAG X 46931; 53749 +PRKAG2 AMPKG2 Q9UGJ0 human 53BP1 7158 Q12888 TP53BP1 human S1317 476252 SSLHRtssGtsLSAM X +PRKAG2 AMPKG2 Q9UGJ0 human SF2 6426 Q07955 SRSF1 human S133 15178110 SGLPPSGsWQDLkDH RRM_1 X +PRKAG2 AMPKG2 Q9UGJ0 human TIF1A 54700 Q9NYV6 RRN3 human S635 11315000 DTHFRsPssSVGsPP X +PRKAG2 AMPKG2 Q9UGJ0 human PDHA1 5160 P08559 PDHA1 human S314 1868287349 IQEVRSksDPIMLLk E1_dh X +PRKAG2 AMPKG2 Q9UGJ0 human STIM1 6786 Q13586 STIM1 human S521 468874 RDLtHsDsEssLHMs X +PRKAG2 AMPKG2 Q9UGJ0 human PDHA1 5160 P08559 PDHA1 human S295 468391 RyHGHsMsDPGVsyR E1_dh X +PRKAG2 AMPKG2 Q9UGJ0 human STIM1 6786 Q13586 STIM1 human S257 468872 GLHRAEQsLHDLQER X +PRKAG2 AMPKG2 Q9UGJ0 human SKP2 27401 Q9Z0Z3 Skp2 mouse S256 1296362400 ATLLSSCsRLDELNL X +PRKAG2 AMPKG2 Q9UGJ0 human SKP2 6502 Q13309 SKP2 human S256 1296362400 QTLLSSCsRLDELNL X +PRKAG2 AMPKG2 Q9UGJ0 human NEDD4L 23327 Q96PU5 NEDD4L human S795 18963100 VDLKPNGsEIMVTNE HECT X +Fyn Fyn P39688 mouse FCGR2C 9103 P31995 FCGR2C human Y310 449501 tDDDKNIyLTLPPND X +Fyn Fyn P39688 mouse CD3E 12501 P22646 Cd3e mouse Y170 448918 PPVPNPDyEPIRKGQ ITAM X +Fyn Fyn P39688 mouse NOX4 50490 Q9JHI8 Nox4 mouse Y566 57848101 LSNRNNSyGTkFEYN X +Fyn Fyn P39688 mouse NYAP2 241134 Q8BM65 Nyap2 mouse Y300 455105 DDQSEAVyEEMKYPI NYAP_N X +Fyn Fyn P39688 mouse NRF2 18024 Q60795 Nfe2l2 mouse Y568 460703 RDEDGKPySPSEYSL X +Fyn Fyn P39688 mouse FCGR2A 2212 P12318 FCGR2A human Y304 449552 tDDDKNIyLTLPPND X +Fyn Fyn P39688 mouse GPRC5B 64297 Q923Z0 Gprc5b mouse Y307 6158489 LQENPPNyFDTSQPR X X +Fyn Fyn P39688 mouse RIAM 54519 Q8R5A3 Apbb1ip mouse Y267 1871479100 FLEKEERyAVFKNPQ X +Fyn Fyn P39688 mouse PKCD 18753 P28867 Prkcd mouse Y311 447573 TTEsVGIyQGFEKKP X X 2055 +Fyn Fyn P39688 mouse NMDAR2B 14812 Q01097 Grin2b mouse Y1472 448167 GSSNGHVyEKLSSIE NMDAR2_C X 4208 +Fyn Fyn P39688 mouse NMDAR2B 14812 Q01097 Grin2b mouse Y1252 448165 CKKAGNLyDIsEDNs NMDAR2_C X +Fyn Fyn P39688 mouse KIRREL 170643 Q80W68 Kirrel1 mouse Y716 455015 DTTSQLSyENyEKFN X +Fyn Fyn P39688 mouse GABRG2 14406 P22723 Gabrg2 mouse Y413 455818 ERDEEyGyECLDGKD Neur_chan_memb X +Fyn Fyn P39688 mouse NMDAR2B 14812 Q01097 Grin2b mouse Y1336 448166 RFMDGsPyAHMFEMP NMDAR2_C X +Fyn Fyn P39688 mouse KIRREL 170643 Q80W68 Kirrel1 mouse Y638 463752 kDPTNGyyNVRAHED X +Fyn Fyn P39688 mouse Srcasm 71943 Q923U0 Tom1l1 mouse Y441 451209 DLQPPNyyEVMEFDP X +Fyn Fyn P39688 mouse CTNNB1 12387 Q02248 Ctnnb1 mouse Y142 449044 AVVNLINyQDDAELA X +Fyn Fyn P39688 mouse IRS1 25467 P35570 Irs1 rat Y895 447556 EPKsPGEyVNIEFGS X 3070 +Fyn Fyn P39688 mouse INDO 15930 P28776 Ido1 mouse Y253 21393601 KLPEGLLyEGVWDTP IDO X +Fyn Fyn P39688 mouse Israa 100188919 B2CXA1 Israa mouse Y102 54065300 PSQLVPEyTEVTSLQ X +Fyn Fyn P39688 mouse CD3E 12501 P22646 Cd3e mouse Y181 448917 RKGQRDLySGLNQRA ITAM X +Fyn Fyn P39688 mouse GPRC5B 64297 Q923Z0 Gprc5b mouse Y330 3972629 EMHLPRAyMENkAFs X X +Fyn Fyn P39688 mouse RIAM 54519 Q8R5A3 Apbb1ip mouse Y427 1871479101 AKYGKTLyDNYQRAV X +Fyn Fyn P39688 mouse IRS1 25467 P35570 Irs1 rat Y1172 451288 GLEKSLNyIDLDLVK X +Fyn Fyn P39688 mouse Srcasm 71943 Q923U0 Tom1l1 mouse Y440 2263200 GDLQPPNyyEVMEFD X +Fyn Fyn P39688 mouse PKCD 18753 P28867 Prkcd mouse Y332 450077 ILDNNGTyGKIWEGS X +Fyn Fyn P39688 mouse WASP 22376 P70315 Was mouse Y293 447985 AETsKLIyDFIEDQG PBD X X +Fyn Fyn P39688 mouse Srcasm 71943 Q923U0 Tom1l1 mouse Y457 451210 APTTEAVyEEIDGYH X +Fyn Fyn P39688 mouse Srcasm 71943 Q923U0 Tom1l1 mouse Y392 451208 NLASSHTyDNFHSNS X +Fyn Fyn P39688 mouse TIM-1 171283 Q5QNS5 Havcr1 mouse Y299 20842101 SRAEDNIyIVEDRP_ X +Fyn Fyn P39688 mouse PSD-93 23859 Q91XM9 Dlg2 mouse Y348 450885 tRPPEPVystVNKLC X +Fyn Fyn P39688 mouse CDK5 12568 P49615 Cdk5 mouse Y15 448022 EkIGEGtyGtVFKAK Pkinase X 94254; 19051 +Fyn Fyn P39688 mouse KIRREL 170643 Q80W68 Kirrel1 mouse Y719 455014 SQLSyENyEKFNSHP X +Fyn Fyn P39688 mouse CTLA-4 12477 P09793 Ctla4 mouse Y201 450897 SPLTTGVyVKMPPTE X +Fyn Fyn P39688 mouse cytohesin 2 19158 P63034 Cyth2 mouse Y381 4003314 AVSVDPFyEMLAARK X +Fyn Fyn P39688 mouse GPRC5B 64297 Q923Z0 Gprc5b mouse Y383 462507 APFRsNVyQPtEMAV X X +Fyn Fyn P39688 mouse NYAP2 241134 Q8BM65 Nyap2 mouse Y277 455101 PEEEEPVyIEMVGNI NYAP_N X +Fyn Fyn P39688 mouse KIRREL 170643 Q80W68 Kirrel1 mouse Y637 463751 MkDPTNGyyNVRAHE X +Fyn Fyn P39688 mouse CTLA-4 12477 P09793 Ctla4 mouse Y218 450898 CEKQFQPyFIPIN__ X +PRKAA1 AMPKA1 Q13131 human AMPKB1 5564 Q9Y478 PRKAB1 human S108 448522 skLPLTRsHNNFVAI AMPK1_CBM X 23021 +PRKAA1 AMPKA1 Q13131 human DRP1 74006 Q8K1M6 Dnm1l mouse S643 483971 VPVARKLsAREQRDC X 4867; 6319 +PRKAA1 AMPKA1 Q13131 human Tau iso8 4137 P10636-8 MAPT human T231 449079 KKVAVVRtPPKsPss X 20473; 71429 +PRKAA1 AMPKA1 Q13131 human ALDH2 217 P05091 ALDH2 human T356 1273608200 GNPFDSktEQGPQVD Aldedh X +PRKAA1 AMPKA1 Q13131 human ATG9A 79065 Q7Z3C6 ATG9A human S761 4722321 QsIPRsAsYPCAAPR X X +PRKAA1 AMPKA1 Q13131 human NRF2 18024 Q60795 Nfe2l2 mouse S550 10292703 HLLKRRLsTLYLEVF bZIP_Maf X +PRKAA1 AMPKA1 Q13131 human HSL 25330 P15304 Lipe rat S865 448804 ESMRRsVsEAALAQP X 4137 +PRKAA1 AMPKA1 Q13131 human PDE4B 18578 Q8VBU5 Pde4b mouse S304 4765135 KKLMHsssLNNtSIS X +PRKAA1 AMPKA1 Q13131 human CBCP1 219771 Q8ND76 CCNY human S326 453488 SARKRsAsADNLtLP X X +PRKAA1 AMPKA1 Q13131 human DBI 1622 P07108 DBI human S21 1880114700 RHLkTkPsDEEMLFI X X +PRKAA1 AMPKA1 Q13131 human OGT 26295 P56558 Ogt rat T444 31828209 EAIASYRtALKLKPD TPR_11 X X +PRKAA1 AMPKA1 Q13131 human FOXO3A 56484 Q9WVH4 Foxo3 mouse S412 12084437 GLMQRGSsFPYTAKs X +PRKAA1 AMPKA1 Q13131 human NET1 10276 Q7Z628 NET1 human S100 3204288 RPLARVTsLANLIsP X +PRKAA1 AMPKA1 Q13131 human IRS1 3667 P35568 IRS1 human S794 447557 QHLRLSTsSGRLLyA X 2389 +PRKAA1 AMPKA1 Q13131 human fumarase 2271 P07954 FH human S75 116533304 yGAQTVRsTMNFkIG Lyase_1 X X +PRKAA1 AMPKA1 Q13131 human PD-L1 29126 Q9NZQ7 CD274 human S283 14735979 DTNsKkQsDtHLEEt X X +PRKAA1 AMPKA1 Q13131 human PARK2 5071 O60260 PRKN human S9 11096954 IVFVRFNssHGFPVE ubiquitin X X +PRKAA1 AMPKA1 Q13131 human AMOTL1 154810 Q8IY63 AMOTL1 human S793 7103446 SSLRPARsVPsIAAA Angiomotin_C X X +PRKAA1 AMPKA1 Q13131 human AMPKA1 5562 Q13131 PRKAA1 human S494 4717473 GtAtPQRsGsVsNyR AdenylateSensor X +PRKAA1 AMPKA1 Q13131 human SNX17 9784 Q15036 SNX17 human S437 468793 VkLSskLsAVsLRGI X +PRKAA1 AMPKA1 Q13131 human HDAC5 10014 Q9UQL6 HDAC5 human S498 447996 RPLSRtQsSPLPQsP X X 3424 +PRKAA1 AMPKA1 Q13131 human mTOR 56717 Q9JLN9 Mtor mouse T2446 450853 NKRsRtRtDsysAGQ X X +PRKAA1 AMPKA1 Q13131 human HIPK2 28996 Q9H2X6 HIPK2 human S121 28847902 LMRRStVsLLDTYQK X +PRKAA1 AMPKA1 Q13131 human TBC1D1 57915 Q60949 Tbc1d1 mouse S700 2228807 KKLHssssVPNFLKF X 6929 +PRKAA1 AMPKA1 Q13131 human PTS 5805 Q03393 PTS human T58 1869465810 HNYKVVVtVHGEIDP PTPS X X +PRKAA1 AMPKA1 Q13131 human MCU 90550 Q8NE86 MCU human S57 27259016 TVHQRIAsWQNLGAV X X +PRKAA1 AMPKA1 Q13131 human GAPDH 2597 P04406 GAPDH human S122 31881707 GAkRVIIsAPsADAP X +PRKAA1 AMPKA1 Q13131 human GFAT iso2 2673 Q06210-2 GFPT1 human S243 467935 CNLsRVDsttCLFPV X X +PRKAA1 AMPKA1 Q13131 human STX16 228960 Q8BVI5 Stx16 mouse T7 4754210 _MATRRLtDAFLLLR X +PRKAA1 AMPKA1 Q13131 human DRP1 10059 O00429 DNM1L human S637 483971 VPVARKLsAREQRDC X 4867; 6319 +PRKAA1 AMPKA1 Q13131 human eNOS 4846 P29474 NOS3 human S1177 447884 TSRIRtQsFsLQERQ X 9571; 9570 +PRKAA1 AMPKA1 Q13131 human VASP 7408 P50552 VASP human T278 448381 LARRRKAtQVGEktP X +PRKAA1 AMPKA1 Q13131 human ACC1 31 Q13085 ACACA human S80 448292 LHIRssMsGLHLVkQ X 3661; 11818; 42801 +PRKAA1 AMPKA1 Q13131 human AMPKA1 5562 Q13131 PRKAA1 human T388 7712505 EtPRARHtLDELNPQ X +PRKAA1 AMPKA1 Q13131 human HSF1 15499 P38532 Hsf1 mouse S121 455480 NIKRKVTsVstLKSE X X +PRKAA1 AMPKA1 Q13131 human PPP1R3C 5507 Q9UQK1 PPP1R3C human S293 6423501 LEStIFGsPRLASGL X +PRKAA1 AMPKA1 Q13131 human 53BP1 7158 Q12888 TP53BP1 human S1317 476252 SSLHRtssGtsLSAM X +PRKAA1 AMPKA1 Q13131 human JAK1 3716 P23458 JAK1 human S518 62372201 GSDRsFPsLGDLMsH X +PRKAA1 AMPKA1 Q13131 human YAP1 10413 P46937 YAP1 human S61 484116 IVHVRGDsEtDLEAL X X 75784; 86312 +PRKAA1 AMPKA1 Q13131 human CAMKK2 83506 O88831 Camkk2 rat T144 15425433 PRMPRRPtVESHHVS X X +PRKAA1 AMPKA1 Q13131 human SF2 6426 Q07955 SRSF1 human S133 15178110 SGLPPSGsWQDLkDH RRM_1 X +PRKAA1 AMPKA1 Q13131 human BTRC 8945 Q9Y297 BTRC human S82 1869876000 SLRQTYNsCARLCLN X +PRKAA1 AMPKA1 Q13131 human RACK1 10399 P63244 RACK1 human T50 23136904 WkLtrDEtNyGIPQR X X +PRKAA1 AMPKA1 Q13131 human AMPKB1 5564 Q9Y478 PRKAB1 human S174 7447518 MVDsQKCsDVsELss X +PRKAA1 AMPKA1 Q13131 human TBC1D1 57915 Q60949 Tbc1d1 mouse S231 2103609 RPMRKsFsQPGLRSL X +PRKAA1 AMPKA1 Q13131 human CAMKK2 83506 O88831 Camkk2 rat T446 286046005 IkLHPWVtRHGAEPL X +PRKAA1 AMPKA1 Q13131 human laforin 7957 O95278 EPM2A human S25 20583300 PELLVVGsRPELGRW CBM_20 X X +PRKAA1 AMPKA1 Q13131 human NRF2 4780 Q16236 NFE2L2 human S374 35497700 GDtLLGLsDsEVEEL X X +PRKAA1 AMPKA1 Q13131 human TSC2 iso2 24855 P49816-2 Tsc2 rat S1346 450212 QPLsKSSsSPELQTL X X 5584; 23402 +PRKAA1 AMPKA1 Q13131 human AMPKB1 5564 Q9Y478 PRKAB1 human T158 7712506 NIIQVKktDFEVFDA AMPK1_CBM X +PRKAA1 AMPKA1 Q13131 human AML3 860 Q13950 RUNX2 human S118 460037 AELVRTDsPNFLCSV Runt X X +PRKAA1 AMPKA1 Q13131 human TIF1A 54700 Q9NYV6 RRN3 human S635 11315000 DTHFRsPssSVGsPP X X +PRKAA1 AMPKA1 Q13131 human SQSTM1 18412 Q64337 Sqstm1 mouse S351 14580829 SsKEVDPsTGELQsL X 95697; 16177; 12074 +PRKAA1 AMPKA1 Q13131 human KLC2 64837 Q9H0B6 KLC2 human S545 3892542 GsLRRsGsFGKLRDA X +PRKAA1 AMPKA1 Q13131 human ATP6V1A 11964 P50516 Atp6v1a mouse S384 485978 YLGARLAsFYERAGR ATP-synt_ab X X +PRKAA1 AMPKA1 Q13131 human HIPK2 28996 Q9H2X6 HIPK2 human T119 28847903 HNLMRRStVsLLDTY X +PRKAA1 AMPKA1 Q13131 human PARP1 142 P09874 PARP1 human S177 18013484 LGFRPEYsAsQLkGF zf-PARP X +PRKAA1 AMPKA1 Q13131 human YAP1 10413 P46937 YAP1 human S94 3253276 RLRkLPDsFFkPPEP X X +PRKAA1 AMPKA1 Q13131 human NRF2 4780 Q16236 NFE2L2 human S408 10292700 GDMVQPLsPSQGQST X X +PRKAA1 AMPKA1 Q13131 human KPNA2 3838 P52292 KPNA2 human S105 454033 QAARkLLsREkQPPI X X +PRKAA1 AMPKA1 Q13131 human PDHA1 5160 P08559 PDHA1 human S314 1868287349 IQEVRSksDPIMLLk E1_dh X X +PRKAA1 AMPKA1 Q13131 human TBC1D1 57915 Q60949 Tbc1d1 mouse T499 2228808 NRAKRsLtEsLEsIL X +PRKAA1 AMPKA1 Q13131 human SIRT7 209011 Q8BKJ9 Sirt7 mouse T264 1874512900 EAAsKADtILCLGSS SIR2 X +PRKAA1 AMPKA1 Q13131 human PDE4B 18578 Q8VBU5 Pde4b mouse S125 4765110 sFLYRSDsDyDLsPK X +PRKAA1 AMPKA1 Q13131 human Tau iso8 4137 P10636-8 MAPT human S214 447929 GsRsRtPsLPtPPtR X 77348 +PRKAA1 AMPKA1 Q13131 human EEF2K 29904 O00418 EEF2K human S398 450686 DsLPssPssAtPHSQ X X +PRKAA1 AMPKA1 Q13131 human CAMKK2 83506 O88831 Camkk2 rat S510 2861414 RREERSLsAPGNLLt X 12818 +PRKAA1 AMPKA1 Q13131 human ULK1 22241 O70405 Ulk1 mouse S317 35495300 SHLASPPsLGEMPQL X X 12753; 37762 +PRKAA1 AMPKA1 Q13131 human SMPD3 55512 Q9NY59 SMPD3 human S209 17547980 GsIKRTAsVEyKGDG X +PRKAA1 AMPKA1 Q13131 human PFKFB2 5208 O60825 PFKFB2 human S466 448460 PVRMRRNsFtPLssS X +PRKAA1 AMPKA1 Q13131 human CFTR 1080 P13569 CFTR human S737 449981 EPLERRLsLVPDSEQ CFTR_R X +PRKAA1 AMPKA1 Q13131 human PERK 9451 Q9NZJ5 EIF2AK3 human S715 4270777 HIEIIAPsPQRsRSF X +PRKAA1 AMPKA1 Q13131 human STIM1 6786 Q13586 STIM1 human S521 468874 RDLtHsDsEssLHMs X +PRKAA1 AMPKA1 Q13131 human Tau iso8 4137 P10636-8 MAPT human S356 449104 rVQskIGsLDNItHV Tubulin-binding X +PRKAA1 AMPKA1 Q13131 human ACC1 107476 Q5SWU9 Acaca mouse S79 448292 FHMRSsMsGLHLVKQ X 3661; 11818; 42801 +PRKAA1 AMPKA1 Q13131 human eNOS 4846 P29474 NOS3 human S633 448637 WRRKRKEssNtDsAG Flavodoxin_1 X +PRKAA1 AMPKA1 Q13131 human PARK2 50873 Q9WVS6 Prkn mouse S9 11096954 IVFVRFNsSYGFPVE ubiquitin X X +PRKAA1 AMPKA1 Q13131 human Kv1.5 3741 P22460 KCNA5 human S592 1269647506 KCNVKAKsNVDLRRS X X +PRKAA1 AMPKA1 Q13131 human FOXO3A 2309 O43524 FOXO3 human S626 20799905 SLECDMEsIIRSELM FOXO-TAD X X +PRKAA1 AMPKA1 Q13131 human p27Kip1 1027 P46527 CDKN1B human T198 448781 PGLRRRQt_______ X +PRKAA1 AMPKA1 Q13131 human EXO1 9156 Q9UQ84 EXO1 human S746 1240803 PGLYkSSsADsLStT X +PRKAA1 AMPKA1 Q13131 human GLI1 2735 P08151 GLI1 human S408 41595600 GPLPRAPsISTVEPk X X +PRKAA1 AMPKA1 Q13131 human DDIT3 1649 P35638 DDIT3 human S30 455503 EDLQEVLssDENGGT X X +PRKAA1 AMPKA1 Q13131 human RBBP7 5931 Q16576 RBBP7 human S314 63080403 LkLHTFEsHkDEIFQ WD40 X X +PRKAA1 AMPKA1 Q13131 human DYNC1I2 13427 O88487 Dync1i2 mouse S81 449148 PIVPPPMsPssKsVs X X +PRKAA1 AMPKA1 Q13131 human TET2 214133 Q4JK59 Tet2 mouse S97 3202572 GGIKRtVsEPSLsGL X +PRKAA1 AMPKA1 Q13131 human PRPS2 5634 P11908 PRPS2 human S180 18014264 GGAkRVTsIADrLNV X X +PRKAA1 AMPKA1 Q13131 human PPP1R12C 54776 Q9BZL4 PPP1R12C human S452 472608 AGLQRsAsssWLEGt X +PRKAA1 AMPKA1 Q13131 human genethonin 1 8987 O95210 STBD1 human S175 469665 CFAEKLPssNLLKNR X +PRKAA1 AMPKA1 Q13131 human ARHGEF7 114559 O55043 Arhgef7 rat S71 3573357 KPSEkPVsPKSGTLK X X +PRKAA1 AMPKA1 Q13131 human PAQR3 152559 Q6TCH7 PAQR3 human T32 53998800 PRGIRLYtyEQIPGS X X +PRKAA1 AMPKA1 Q13131 human KLC2 64837 Q9H0B6 KLC2 human S582 452949 PRMKRAssLNFLNKs X +PRKAA1 AMPKA1 Q13131 human SMPD3 58994 Q9JJY3 Smpd3 mouse S208 17547980 GsIKRTAsVEYKGDG X +PRKAA1 AMPKA1 Q13131 human p53 7157 P04637 TP53 human T18 447541 EPPLsQEtFsDLWkL P53_TAD X 2529 +PRKAA1 AMPKA1 Q13131 human EGFR 1956 P00533 EGFR human T892 41590814 SILHRIytHQSDVWS PK_Tyr_Ser-Thr X +PRKAA1 AMPKA1 Q13131 human AMPKA1 5562 Q13131 PRKAA1 human S486 3195155 DEItEAksGtAtPQR AdenylateSensor X +PRKAA1 AMPKA1 Q13131 human MED1 19014 Q925J9 Med1 mouse S671 1210794 sPLERQNsssGsPRM X +PRKAA1 AMPKA1 Q13131 human GBF1 8729 Q92538 GBF1 human T1338 454448 GKIHRsAtDADVVNs X X +PRKAA1 AMPKA1 Q13131 human Tau iso8 4137 P10636-8 MAPT human S396 449081 GAEIVyKsPVVsGDt X 9632 +PRKAA1 AMPKA1 Q13131 human PDE4B 18578 Q8VBU5 Pde4b mouse S118 449097 GHSQRREsFLYRSDs X +PRKAA1 AMPKA1 Q13131 human TBC1D1 57915 Q60949 Tbc1d1 mouse S621 2228806 RKLMRYHsVstETPH X +PRKAA1 AMPKA1 Q13131 human UMPS 7372 P11172 UMPS human S214 3180453 VAANHNGsPLsIkEA X +PRKAA1 AMPKA1 Q13131 human p53 7157 P04637 TP53 human S20 447529 PLsQEtFsDLWkLLP P53_TAD X 9287 +PRKAA1 AMPKA1 Q13131 human PRPS1 5631 P60891 PRPS1 human S180 18014261 GGAkRVTsIADrLNV X X +PRKAA1 AMPKA1 Q13131 human TNNI3 7137 P19429 TNNI3 human S23 448423 PAPIRRRssNyRAyA Troponin-I_N X 4004 +PRKAA1 AMPKA1 Q13131 human HOXB9 15417 P20615 Hoxb9 mouse T133 31087958 GELLKQGtPEYSLET Hox9_act X X +PRKAA1 AMPKA1 Q13131 human PDHA1 5160 P08559 PDHA1 human S295 468391 RyHGHsMsDPGVsyR E1_dh X X +PRKAA1 AMPKA1 Q13131 human STIM1 6786 Q13586 STIM1 human S257 468872 GLHRAEQsLHDLQER X +PRKAA1 AMPKA1 Q13131 human beclin 1 8678 Q14457 BECN1 human S93 5473540 ARMMstEsANsFTLI X 14717 +PRKAA1 AMPKA1 Q13131 human EGLN1 54583 Q9GZT9 EGLN1 human S61 56668114 HKLVCQGsEGALGHG X X +PRKAA1 AMPKA1 Q13131 human Raptor 57521 Q8N122 RPTOR human S792 2314600 DKMRRAssYSsLNSL X X 2083; 89146 +PRKAA1 AMPKA1 Q13131 human CAMKK2 83506 O88831 Camkk2 rat S110 286046004 RSQGGPAsSSSLDMN X +PRKAA1 AMPKA1 Q13131 human AMPKA1 5562 Q13131 PRKAA1 human S496 450431 AtPQRsGsVsNyRSC AdenylateSensor X 4185; 4184; 2537 +PRKAA1 AMPKA1 Q13131 human PERK 9451 Q9NZJ5 EIF2AK3 human S856 23130887 SEATLsIsPPRPTTL X +PRKAA1 AMPKA1 Q13131 human MED1 19014 Q925J9 Med1 mouse S771 1219246 QRMVRLsssDsIGPD X +PRKAA1 AMPKA1 Q13131 human SIRT1 23411 Q96EB6 SIRT1 human T344 25594500 GkLLRNYtQNIDTLE SIR2 X +PRKAA1 AMPKA1 Q13131 human NKCC2 6557 Q13621 SLC12A1 human S130 478420 GPKVNRPsLLEIHEQ AA_permease_N X +PRKAA1 AMPKA1 Q13131 human PIAS1 8554 O75925 PIAS1 human S510 14160798 sPVsRtPsLPAVDTS X +PRKAA1 AMPKA1 Q13131 human Tau iso8 4137 P10636-8 MAPT human S262 447930 NVKskIGstENLkHQ Tubulin-binding X +PRKAA1 AMPKA1 Q13131 human PDLIM5 56376 Q8CI51 Pdlim5 mouse S177 38546304 TPLHLSAsGLHVSAN X +PRKAA1 AMPKA1 Q13131 human PPP2R5C 5527 Q13362 PPP2R5C human S298 7643503 KYWPKTHsPKEVMFL B56 X +PRKAA1 AMPKA1 Q13131 human HNF4 alpha 3172 P41235 HNF4A human S313 449926 GkIkRLRsQVQVsLE Hormone_recep X +PRKAA1 AMPKA1 Q13131 human AMPKA1 5562 Q13131 PRKAA1 human T183 448786 sDGEFLRtsCGsPNy Pkinase X X 2535; 2531; 4188; 5256; 50081; 74281 +PRKAA1 AMPKA1 Q13131 human ULK1 22241 O70405 Ulk1 mouse S467 483136 sAIRRsGsttPLGFG X X 4634 +PRKAA1 AMPKA1 Q13131 human CK1E 1454 P49674 CSNK1E human S389 482888 rGAPANVsssDLtGR X +PRKAA1 AMPKA1 Q13131 human HER2 2064 P04626 ERBB2 human T900 41590813 SILRRRFtHQSDVWS PK_Tyr_Ser-Thr X +PRKAA1 AMPKA1 Q13131 human USP10 9100 Q14694 USP10 human S76 3831744 DtLPRtPsySISstL X X +PRKAA1 AMPKA1 Q13131 human Kv1.5 3741 P22460 KCNA5 human S559 1269647505 VQRKVsGsRGSFCKA X X +PRKAA1 AMPKA1 Q13131 human Mnk1 iso2 8569 Q9BUB5-2 MKNK1 human S353 56790200 QVLQRNSsTMDLTLF X X +PRKAA1 AMPKA1 Q13131 human SIRT7 51547 Q9NRC8 SIRT7 human T153 125108501 TLTHMSItRLHEQKL SIR2 X X +PRKAA1 AMPKA1 Q13131 human BRAF iso1 109880 P28028-1 Braf mouse S766 450242 PKIHRSAsEPsLNRA X +PRKAA1 AMPKA1 Q13131 human AMPKB1 5564 Q9Y478 PRKAB1 human T80 7712507 APAQARPtVFRWTGG AMPK1_CBM X +PRKAA1 AMPKA1 Q13131 human Rb 19645 P13405 Rb1 mouse S804 448717 IyIsPLksPyKIsEG Rb_C X 9308; 8974; 4277; 40283; 8957; 8516; 11917; 41359; 75864 +PRKAA1 AMPKA1 Q13131 human FANCA 2175 O15360 FANCA human S347 56793101 VQMQREWsFARtHPL Fanconi_A_N X +PRKAA1 AMPKA1 Q13131 human beclin 1 8678 Q14457 BECN1 human T388 56689904 EEVEKGEtRFCLPYR APG6 X X +PRKAA1 AMPKA1 Q13131 human KLF10 21847 O89091 Klf10 mouse T188 25743268 DNSFRRRtHGNVEAT X +PRKAA1 AMPKA1 Q13131 human Restin 56430 Q922J3 Clip1 mouse S311 4769833 AsLKRsPsAssLSSM X +PRKAA1 AMPKA1 Q13131 human RASAL2 iso2 9462 Q9UJF2-2 RASAL2 human S351 1872043503 TLFARTTsKTKADNI C2 X X +PRKAA1 AMPKA1 Q13131 human DFNA5 1687 O60443 GSDME human T6 50777052 __MFAkAtRNFLREV Gasdermin X X +PRKAA1 AMPKA1 Q13131 human KIF4A 24137 O95239 KIF4A human S801 459849 KLRRRtFsLTEVRGQ X X +PRKAA1 AMPKA1 Q13131 human ChREBP 171078 Q8VIP2 Mlxipl rat S568 451262 TLLRPPEsPDAVPEI X +PRKAA1 AMPKA1 Q13131 human GSDMD 69146 Q9D8T2 Gsdmd mouse S46 1883583906 CLLNRKFsSSRFWKP Gasdermin X X +PRKAA1 AMPKA1 Q13131 human ULK1 8408 O75385 ULK1 human S638 3176158 FDFPKtPssQNLLAL X 14205 +PRKAA1 AMPKA1 Q13131 human FOXO3A 2309 O43524 FOXO3 human S555 20799903 RALsNsVsNMGLSES X X +PRKAA1 AMPKA1 Q13131 human NCL 4691 P19338 NCL human S328 31867151 PELktGIsDVFAkND RRM_1 X X +PRKAA1 AMPKA1 Q13131 human PPP1R3C 5507 Q9UQK1 PPP1R3C human S33 6423500 MRLCLAHsPPVKSFL X +PRKAA1 AMPKA1 Q13131 human AMPKB1 5564 Q9Y478 PRKAB1 human S177 7447522 sQKCsDVsELsssPP X +PRKAA1 AMPKA1 Q13131 human ZNF692 55657 Q9BU19 ZNF692 human S470 471395 VAAHRSKsHPALLLA X +PRKAA1 AMPKA1 Q13131 human HIPK2 28996 Q9H2X6 HIPK2 human T1114 28847906 APAALGStGTVAHLV X +PRKAA1 AMPKA1 Q13131 human Raptor 74370 Q8K4Q0 Rptor mouse S792 2314600 DKMRRVSsYSALNSL X 2083; 89146 +PRKAA1 AMPKA1 Q13131 human TSC2 iso2 24855 P49816-2 Tsc2 rat T1228 450211 PTLPRSNtVASFSSL X X +PRKAA1 AMPKA1 Q13131 human ULK1 22241 O70405 Ulk1 mouse S777 4699310 TRMFsVGsSSsLGST X X +PRKAA1 AMPKA1 Q13131 human CHKA 1119 P35790 CHKA human S279 1876872804 kKLHKLLsYNLPLEL Choline_kinase X +PRKAA1 AMPKA1 Q13131 human eNOS 287024 P29473 NOS3 cow S1179 447884 TSRIRtQsFsLQERH X 9570 +PRKAA1 AMPKA1 Q13131 human p73 7161 O15350 TP73 human S426 33602702 GGMNKLPsVNQLVGQ X X +PRKAA1 AMPKA1 Q13131 human TSC2 7249 P49815 TSC2 human S1387 450212 QPLsKssssPELQtL X X 5584; 23402 +PRKAA1 AMPKA1 Q13131 human Kv2.1 25736 P15387 Kcnb1 rat S444 4714867 ERAKRNGsIVsMNMK X +PRKAA1 AMPKA1 Q13131 human HSL 3991 Q05469 LIPE human S855 448804 EPMRRsVsEAALAQP X X 4137 +PRKAA1 AMPKA1 Q13131 human FOXO3A 2309 O43524 FOXO3 human T179 20799901 SSPDKRLtLSQIyEW Forkhead X X +PRKAA1 AMPKA1 Q13131 human FOXO3A 2309 O43524 FOXO3 human S588 20799904 QTLSDSLsGSSLYST X X +PRKAA1 AMPKA1 Q13131 human CAMKK2 83506 O88831 Camkk2 rat S552 286046003 SPCGGGGsALVKGGP X +PRKAA1 AMPKA1 Q13131 human FOXO3A 2309 O43524 FOXO3 human S30 478738 EPQsRPRsCtWPLQR X +PRKAA1 AMPKA1 Q13131 human TNNI2 29389 P27768 Tnni2 rat S118 4702728 PLRRVRMsADAMLkA Troponin X +PRKAA1 AMPKA1 Q13131 human PNPLA2 66853 Q8BJ56 Pnpla2 mouse S406 473045 VELRRAQsLPsVPLS X X +PRKAA1 AMPKA1 Q13131 human beclin 1 8678 Q14457 BECN1 human S96 472002 MstEsANsFTLIGEA X +PRKAA1 AMPKA1 Q13131 human TBC1D1 57915 Q60949 Tbc1d1 mouse T253 2228805 DASLRSStFssFDND X +PRKAA1 AMPKA1 Q13131 human ZNF9 12785 P53996 Cnbp mouse T173 471955 GHLARECtIEAtA__ zf-CCHC X +PRKAA1 AMPKA1 Q13131 human PPP2R5C 5527 Q13362 PPP2R5C human S336 7643502 RQLAkCVsSPHFQVA B56 X +PRKAA1 AMPKA1 Q13131 human Kir6.2 P70673 Kcnj11 rat S385 2103601 AKPKFSIsPDSLs__ X +PRKAA1 AMPKA1 Q13131 human FOXO3A 2309 O43524 FOXO3 human S413 12084437 GLMQRSSsFPYTTKG X X 8174 +PRKAA1 AMPKA1 Q13131 human GFAT 2673 Q06210 GFPT1 human S261 467935 CNLsRVDsttCLFPV X +PRKAA1 AMPKA1 Q13131 human GATAD2A 234366 Q8CHY6 Gatad2a mouse S96 453704 KSEKRPPsPDVIVLs X +PRKAA1 AMPKA1 Q13131 human TET2 54790 Q6N021 TET2 human S99 3202572 GGIKRtVsEPsLSGL X X +PRKAA1 AMPKA1 Q13131 human EZH2 2146 Q15910 EZH2 human T311 34490427 NtYkRKNtETALDNk X X 27888; 70303 +PRKAA1 AMPKA1 Q13131 human SREBP-1 iso3 6720 P36956-3 SREBF1 human S372 4934079 TAVHKSKsLKDLVSA X X 9874 +PRKAA1 AMPKA1 Q13131 human SCFD1 23256 Q8WVM8 SCFD1 human S316 27461658 PKRKNKksYDLTPVD Sec1 X X +PRKAA1 AMPKA1 Q13131 human GSR 2936 P00390 GSR human T507 23111522 TkADFDNtVAIHPts Pyr_redox_dim X +PRKAA1 AMPKA1 Q13131 human ULK1 8408 O75385 ULK1 human S556 3176155 GLGCRLHsAPNLsDL X 5869 +PRKAA1 AMPKA1 Q13131 human p300 2033 Q09472 EP300 human S89 447592 SELLRSGsSPNLNMG X X +PRKAA1 AMPKA1 Q13131 human CFTR 1080 P13569 CFTR human S768 455300 LQARRRQsVLNLMtH CFTR_R X +PRKAA1 AMPKA1 Q13131 human TBC1D1 23216 Q86TI0 TBC1D1 human T596 1247778 AFRRRANtLsHFPIE X +PRKAA1 AMPKA1 Q13131 human FOXO3A 2309 O43524 FOXO3 human S399 20799902 DNItLPPsQPsPTGG X X +PRKAA1 AMPKA1 Q13131 human genethonin 1 52331 Q8C7E7 Stbd1 mouse S167 469665 SVAAkLPsSSLLVDR X +PRKAA1 AMPKA1 Q13131 human CAMKK2 83506 O88831 Camkk2 rat S126 286046006 RCICPSLsYSPASSP X +PRKAA1 AMPKA1 Q13131 human SKP2 27401 Q9Z0Z3 Skp2 mouse S256 1296362400 ATLLSSCsRLDELNL X X +PRKAA1 AMPKA1 Q13131 human ZDHHC13 54503 Q8IUH4 ZDHHC13 human S208 1880741000 FLLKFNPsLNVVDkI X X +PRKAA1 AMPKA1 Q13131 human CAMKK2 83506 O88831 Camkk2 rat S135 454104 SPASSPQsSPRMPRR X +PRKAA1 AMPKA1 Q13131 human TXNIP 10628 Q9H3M7 TXNIP human S308 277409200 GLssRTssMASRTsS X +PRKAA1 AMPKA1 Q13131 human HDAC5 10014 Q9UQL6 HDAC5 human S259 447995 FPLRkTAsEPNLKVR X X 3443 +PRKAA1 AMPKA1 Q13131 human CAMKK2 83506 O88831 Camkk2 rat S494 469882 KTMIRKRsFGNPFEG X 16737; 35392 +PRKAA1 AMPKA1 Q13131 human KLC1 3831 Q07866 KLC1 human S521 468108 ENMEkRRsREsLNVD X +PRKAA1 AMPKA1 Q13131 human AMPKB1 5564 Q9Y478 PRKAB1 human S24 448111 HKtPRRDssGGtKDG X +PRKAA1 AMPKA1 Q13131 human TBC1D1 57915 Q60949 Tbc1d1 mouse S660 2228809 PRLNPSAssPNFFKY X 6928 +PRKAA1 AMPKA1 Q13131 human ULK1 8408 O75385 ULK1 human S317 35495300 SHLASPPsLGEMQQL X 12753; 37762 +PRKAA1 AMPKA1 Q13131 human DNMT1 iso2 1786 P26358-2 DNMT1 human S730 452655 DNIPEMPsPKKMHQG X X +PRKAA1 AMPKA1 Q13131 human GABBR2 83633 O88871 Gabbr2 rat S783 473060 VTSVNQAsTSRLEGL GBR2_CC X X +PRKAA1 AMPKA1 Q13131 human GAPVD1 26130 Q14C86 GAPVD1 human S902 468085 ErLVRsRssDIVSsV X +PRKAA1 AMPKA1 Q13131 human HSF1 3297 Q00613 HSF1 human S121 455480 NIkRkVtsVSTLksE X X +PRKAA1 AMPKA1 Q13131 human TBC1D1 57915 Q60949 Tbc1d1 mouse T590 1247778 AFRRRANtLsHFPVE X +PRKAA1 AMPKA1 Q13131 human PFKFB3 5209 Q16875 PFKFB3 human S461 448801 NPLMRRNsVtPLAsP X X +PRKAA1 AMPKA1 Q13131 human Kv2.1 25736 P15387 Kcnb1 rat S541 473556 SKMAKTQsQPILNTK Kv2channel X +PRKAA1 AMPKA1 Q13131 human PBEF 10135 P43490 NAMPT human S314 40512819 PLIIRPDsGNPLDTV NAPRTase X X +PRKAA1 AMPKA1 Q13131 human AMPKA1 5562 Q13131 PRKAA1 human S360 7320945 LAtsPPDsFLDDHHL X +PRKAA1 AMPKA1 Q13131 human CGN 57530 Q9P2M7 CGN human S137 457044 GKLLRsHsQAsLAGP X +PRKAA1 AMPKA1 Q13131 human CRY1 12952 P97784 Cry1 mouse S71 11952908 ANLRKLNsRLFVIRG DNA_photolyase X +PRKAA1 AMPKA1 Q13131 human SIRT2 22933 Q8IXJ6 SIRT2 human T101 31839907 PDFRSPStGLyDNLE SIR2 X +PRKAA1 AMPKA1 Q13131 human Oct1 5451 P14859 POU2F1 human S335 10424763 RFEALNLsFKNMCKL Pou X +PRKAA1 AMPKA1 Q13131 human CTBP1 1487 Q13363 CTBP1 human S158 455351 REGTRVQsVEQIREV 2-Hacid_dh_C; 2-Hacid_dh X +PRKAA1 AMPKA1 Q13131 human SKP2 6502 Q13309 SKP2 human S256 1296362400 QTLLSSCsRLDELNL X X +PRKAA1 AMPKA1 Q13131 human NKCC1 6558 P55011 SLC12A2 human S77 3192079 RPLGPtPsQsRFQVD X X +PRKAA1 AMPKA1 Q13131 human TBC1D1 23216 Q86TI0 TBC1D1 human S237 2103609 RPMRKsFsQPGLRSL X X +PRKAA1 AMPKA1 Q13131 human p27Kip1 12576 P46414 Cdkn1b mouse T197 448781 KPGLRRQt_______ X +PRKAA1 AMPKA1 Q13131 human MED1 19014 Q925J9 Med1 mouse S811 28758703 GtPVRDSsSSGHSQS X +PRKAA1 AMPKA1 Q13131 human Cortactin 2017 Q14247 CTTN human T401 449245 QARAKtQtPPVsPAP X X +PRKAA1 AMPKA1 Q13131 human SCFD1 23256 Q8WVM8 SCFD1 human S303 3207654 EssGVENsPAGARPK Sec1 X X +PRKAA1 AMPKA1 Q13131 human NKCC1 6558 P55011 SLC12A2 human S242 18912156 GEkLLRPsLAELHDE AA_permease_N X X +PRKAA1 AMPKA1 Q13131 human PD-L1 29126 Q9NZQ7 CD274 human S195 796148000 EKLFNVtsTLRINTT C2-set_2 X X +PRKAA1 AMPKA1 Q13131 human BRAF 673 P15056 BRAF human S729 450242 PKIHRSAsEPsLNRA X X +PRKAA1 AMPKA1 Q13131 human NRF2 4780 Q16236 NFE2L2 human S433 27461383 PEKELPVsPGHrktP X X +PRKAA1 AMPKA1 Q13131 human Tau iso8 4137 P10636-8 MAPT human S422 449083 GsIDMVDsPQLAtLA X +PRKAA1 AMPKA1 Q13131 human EGLN1 54583 Q9GZT9 EGLN1 human S136 1877121600 AAAGGQGsAVAAEAE X X +PRKAA1 AMPKA1 Q13131 human SCN5A 6331 Q14524 SCN5A human T101 1867858201 IVLNKGKtIFRFSAT X X +PRKAA1 AMPKA1 Q13131 human GABBR1 81657 Q9Z0U4 Gabbr1 rat S948 473059 ELRHQLQsRQQLRSR X +PRKAA1 AMPKA1 Q13131 human AMPKB1 5564 Q9Y478 PRKAB1 human T148 7447514 IVTsQLGtVNNIIQV AMPK1_CBM X +PRKAA1 AMPKA1 Q13131 human ULK1 22241 O70405 Ulk1 mouse S555 3176155 GLGCRLHsAPNLSDF X X 5869 +PRKAA1 AMPKA1 Q13131 human TNNI3 7137 P19429 TNNI3 human S150 451822 tLRrVrIsADAMMQA Troponin X X +PRKAA1 AMPKA1 Q13131 human HAT1 8520 O14929 HAT1 human S190 63080404 MWFIETAsFIDVDDE X X +PRKAA1 AMPKA1 Q13131 human CFTR 1080 P13569 CFTR human S813 449983 DIYsRRLsQEtGLEI CFTR_R X X +PRKAA1 AMPKA1 Q13131 human FOXO1A 2308 Q12778 FOXO1 human T649 35486505 PHSVKTttHsWVsG_ X X +PRKAA1 AMPKA1 Q13131 human beclin 1 8678 Q14457 BECN1 human S90 472001 IPPARMMstEsANsF X 29362; 86455 +PRKAA1 AMPKA1 Q13131 human GAPVD1 66691 Q6PAR5 Gapvd1 mouse S902 468085 ERLVRsRssDIVSsV X +PRKAA1 AMPKA1 Q13131 human CAMKK2 83506 O88831 Camkk2 rat S174 286046000 KDEIGKGsYGVVKLA Pkinase X +PRKAA1 AMPKA1 Q13131 human NEDD4L 23327 Q96PU5 NEDD4L human S795 18963100 VDLKPNGsEIMVTNE HECT X +PRKAA1 AMPKA1 Q13131 human INSIG1 3638 O15503 INSIG1 human T222 1868139204 ItIAFLAtLITQFLV TM; INSIG X +PRKAA1 AMPKA1 Q13131 human Raptor 57521 Q8N122 RPTOR human S722 2314601 PrLrsVssyGNIRAV X +PRKAA1 AMPKA1 Q13131 human FOXO1A 2308 Q12778 FOXO1 human S22 1869008600 EPLPRPRsCtWPLPR X +PRKAA1 AMPKA1 Q13131 human Syk 6850 P43405 SYK human S178 25687503 GKISREEsEQIVLIG SH2 X +PRKAA1 AMPKA1 Q13131 human ACSS2 55902 Q9NR19 ACSS2 human S659 83970101 PGLPKTRsGKIMRRV AMP-binding_C X +PRKAA1 AMPKA1 Q13131 human TNNI3 7137 P19429 TNNI3 human S24 448424 APIRRRssNyRAyAt Troponin-I_N X 4004 +PRKAA1 AMPKA1 Q13131 human DBC-1 57805 Q8N163 CCAR2 human S808 9426781 ALVsHNGsLINVGsL X X +PRKAA1 AMPKA1 Q13131 human JAK1 3716 P23458 JAK1 human S515 62372200 SLHGSDRsFPsLGDL X +PRKAA1 AMPKA1 Q13131 human TSC2 24855 P49816 Tsc2 rat S1389 450212 QPLsKSSsSPELQTL X 5584; 23402 +PRKAA1 AMPKA1 Q13131 human HSL 16890 P54310 Lipe mouse S559 448804 ESMRRsVsEAALAQP X X 4137 +PRKAA1 AMPKA1 Q13131 human PDE4D iso6 24627 P14270-6 Pde4d rat S81 33670300 KSMSRNSsIASDIHG X +PRKAA1 AMPKA1 Q13131 human smMLCK 396445 P11799 MYLK chicken S1749 466361 RAIGRLSsMAMISGM X +PRKAA1 AMPKA1 Q13131 human CYCS 510767 P62894 CYCS cow T29 4710693 EkGGkHktGPNLHGL Cytochrom_C X +PRKAA1 AMPKA1 Q13131 human ACC2 32 O00763 ACACB human S222 448808 PtMRPsMsGLHLVKR X 3661; 11818; 42801 +PRKAA1 AMPKA1 Q13131 human NR2C2 22026 P49117 Nr2c2 mouse S351 7990482 HVISRDQstPIIEVE X X +PRKAA1 AMPKA1 Q13131 human SQSTM1 8878 Q13501 SQSTM1 human S294 31872178 ssCCsDPskPGGNVE X +PRKAA1 AMPKA1 Q13131 human MAP4 17758 P27546 Map4 mouse S914 1210622 SVRsKVGstENIKHQ Tubulin-binding X +PRKAA1 AMPKA1 Q13131 human KCNMA1 iso4 16531 Q08460-4 Kcnma1 mouse S722 18264900 GRSERDCsCMSGRVR X +CDK12 CDK12 Q9NYV4 human PAK2 5062 Q13177 PAK2 human T134 15413019 LkFyDsNtVkQKyLs X X +CDK12 CDK12 Q9NYV4 human POLR2A 5430 P24928 POLR2A human S1616 450204 TPQSPSysPtsPsYS RNA_pol_Rpb1_R X X 4735; 13499; 13546; 31262 +CDK12 CDK12 Q9NYV4 human PAK2 5062 Q13177 PAK2 human T169 471473 TEAPAVVtEEEDDDE X X +CDK12 CDK12 Q9NYV4 human p63 iso2 8626 Q9H3D4-2 TP63 human S68 451601 TFDALsPsPAIPSNT X +CDK12 CDK12 Q9NYV4 human POLR2A 5430 P24928 POLR2A human S1619 447616 SPSysPtsPsYSPTS RNA_pol_Rpb1_R X 4735; 13523; 13546; 67221 +CDK12 CDK12 Q9NYV4 human p63 iso2 8626 Q9H3D4-2 TP63 human S66 451600 SSTFDALsPsPAIPS X +CDK12 CDK12 Q9NYV4 human p63 iso2 8626 Q9H3D4-2 TP63 human S301 451602 TSIKKRRsPDDELLY P53_tetramer X +CAMK4 CAMK4 Q16566 human QIK 315649 Q3LRT3 Sik2 rat T484 478056 RSGQRRHtLSEVTNQ X +CAMK4 CAMK4 Q16566 human HDAC5 10014 Q9UQL6 HDAC5 human S498 447996 RPLSRtQsSPLPQsP X X 3424 +CAMK4 CAMK4 Q16566 human CREB 1385 P16220 CREB1 human S119 448228 EILsRRPsyRkILND pKID X 9187; 9196; 9198; 4095; 14228; 14001; 39561; 80120; 44864; 54960; 95995 +CAMK4 CAMK4 Q16566 human hnRNP L 3191 P14866 HNRNPL human S544 15436636 GkSERSssGLLEWES X X +CAMK4 CAMK4 Q16566 human CBP 54244 Q6JHU9 Crebbp rat S301 448068 PQLASKQsMVNSLPA X X +CAMK4 CAMK4 Q16566 human NOVA2 4858 Q9UNW9 NOVA2 human T27 1869341902 VCTKRsNtGEEGEYF X +CAMK4 CAMK4 Q16566 human NOVA2 4858 Q9UNW9 NOVA2 human S194 1869341903 EQVHKAVsAIVQKVQ KH_1 X +CAMK4 CAMK4 Q16566 human CBP 12914 P45481 Crebbp mouse S301 448068 PQLASKQsMVNSLPA X X +CAMK4 CAMK4 Q16566 human BAP37 11331 Q99623 PHB2 human S91 22342307 RARPRkIssPTGSkD Band_7 X X +CAMK4 CAMK4 Q16566 human CREB iso1 81646 P15337-1 Creb1 rat S133 448228 EILsRRPsYRkILND pKID X 9187; 9196; 9198; 4095; 14228; 14001; 39561; 80120; 44864; 54960; 95995 +CAMK4 CAMK4 Q16566 human CAMK2A iso2 815 Q9UQM7-2 CAMK2A human S332 3143902 DGVKkRKssssVQLM X +CAMK4 CAMK4 Q16566 human NFkB-p65 5970 Q04206 RELA human S536 447800 sGDEDFSsIADMDFS X 4887; 3036; 3031; 4886; 3033; 4025; 5733; 13346; 76778; 31553; 80477; 73992; 87672; 83962 +CAMK4 CAMK4 Q16566 human NOVA2 4858 Q9UNW9 NOVA2 human S25 1869341901 EVVCTKRsNtGEEGE X +CAMK4 CAMK4 Q16566 human HDAC5 10014 Q9UQL6 HDAC5 human S259 447995 FPLRkTAsEPNLKVR X X 3443 +CAMK4 CAMK4 Q16566 human STMN1 3925 P16949 STMN1 human S16 448554 kELEKrAsGQAFELI Stathmin X 3353 +CAMK4 CAMK4 Q16566 human MYH9 25745 Q62812 Myh9 rat T1940 452194 RRIVRKGtGDCsDEE X +GSK3B GSK3B G1T8E2 rabbit GSK3B 84027 P18266 Gsk3b rat S9 449111 SGRPRTTsFAESCKP X 9336; 9331; 9327; 9323; 9322; 9325; 5558; 8566; 79774; 8466; 25462; 14026; 14332; 14310; 14630 +GSK3B GSK3B G1T8E2 rabbit HSL 25330 P15304 Lipe rat S865 448804 ESMRRsVsEAALAQP X 4137 +GSK3B GSK3B G1T8E2 rabbit GYS1 100008660 P13834 GYS1 rabbit S649 448239 VPPsPSLsRHSsPHQ Glycogen_syn X +GSK3B GSK3B G1T8E2 rabbit SCN2A 24766 P04775 Scn2a rat T1966 4692783 TPEKtDVtPsttsPP X +GSK3B GSK3B G1T8E2 rabbit GYS1 100008660 P13834 GYS1 rabbit S641 448237 YRYPRPAsVPPsPSL Glycogen_syn X +GSK3B GSK3B G1T8E2 rabbit GYS1 100008660 P13834 GYS1 rabbit S645 448238 RPAsVPPsPSLsRHS Glycogen_syn X +GSK3B GSK3B G1T8E2 rabbit VHL 7428 P40337 VHL human S68 469116 PVLRSVNsREPsQVI VHL X +GSK3B GSK3B G1T8E2 rabbit IRF1 16362 P15314 Irf1 mouse T181 1380568700 LDMERDItPALsPCV X +GSK3B GSK3B G1T8E2 rabbit GYS1 100008660 P13834 GYS1 rabbit S653 448240 PSLsRHSsPHQsEDE Glycogen_syn X +GSK3B GSK3B G1T8E2 rabbit FGF14 2259 Q92915 FGF14 human S226 93432000 PkPGVTPsKsTsASA X +PRKAA2 AMPKA2 P54646 human p53 22059 P02340 Tp53 mouse S18 447490 IsLELPLsQEtFsGL P53_TAD X 9284; 9286; 12571; 56979 +PRKAA2 AMPKA2 P54646 human REEP1 65055 Q9H902 REEP1 human S152 454487 SERLRsFsMQDLTTI X +PRKAA2 AMPKA2 P54646 human PLD1 5337 Q13393 PLD1 human S505 11091057 GsVkRVTsGPsLGSL X X +PRKAA2 AMPKA2 P54646 human HDAC5 10014 Q9UQL6 HDAC5 human S498 447996 RPLSRtQsSPLPQsP X 3424 +PRKAA2 AMPKA2 P54646 human HIPK2 28996 Q9H2X6 HIPK2 human S121 28847902 LMRRStVsLLDTYQK X +PRKAA2 AMPKA2 P54646 human ACC1 31 Q13085 ACACA human S80 448292 LHIRssMsGLHLVkQ X X 3661; 11818; 42801 +PRKAA2 AMPKA2 P54646 human 53BP1 7158 Q12888 TP53BP1 human S1317 476252 SSLHRtssGtsLSAM X X +PRKAA2 AMPKA2 P54646 human TBC1D1 57915 Q60949 Tbc1d1 mouse S231 2103609 RPMRKsFsQPGLRSL X +PRKAA2 AMPKA2 P54646 human HIPK2 28996 Q9H2X6 HIPK2 human T119 28847903 HNLMRRStVsLLDTY X +PRKAA2 AMPKA2 P54646 human PARP1 142 P09874 PARP1 human S177 18013484 LGFRPEYsAsQLkGF zf-PARP X +PRKAA2 AMPKA2 P54646 human PDHA1 5160 P08559 PDHA1 human S314 1868287349 IQEVRSksDPIMLLk E1_dh X +PRKAA2 AMPKA2 P54646 human EEF2K 29904 O00418 EEF2K human S398 450686 DsLPssPssAtPHSQ X +PRKAA2 AMPKA2 P54646 human DUSP1 1843 P28562 DUSP1 human S334 53736000 AVLDRGTsTTTVFNF X X +PRKAA2 AMPKA2 P54646 human CDC27 996 P30260 CDC27 human S379 5965291 NALPRRssRLFtsDs X X +PRKAA2 AMPKA2 P54646 human ACC1 107476 Q5SWU9 Acaca mouse S79 448292 FHMRSsMsGLHLVKQ X 3661; 11818; 42801 +PRKAA2 AMPKA2 P54646 human PGC-1 alpha 19017 O70343 Ppargc1a mouse S538 486320 SLFDVSPsCSSFNSP X +PRKAA2 AMPKA2 P54646 human FOXO3A 2309 O43524 FOXO3 human S626 20799905 SLECDMEsIIRSELM FOXO-TAD X +PRKAA2 AMPKA2 P54646 human PARP1 11545 P11103 Parp1 mouse S177 18013484 LGFRPEYsASQLKGF zf-PARP X +PRKAA2 AMPKA2 P54646 human GLI1 2735 P08151 GLI1 human S408 41595600 GPLPRAPsISTVEPk X X +PRKAA2 AMPKA2 P54646 human DYNC1I2 13427 O88487 Dync1i2 mouse S81 449148 PIVPPPMsPssKsVs X +PRKAA2 AMPKA2 P54646 human PPP1R12C 54776 Q9BZL4 PPP1R12C human S452 472608 AGLQRsAsssWLEGt X X +PRKAA2 AMPKA2 P54646 human PINK1 65018 Q9BXM7 PINK1 human S228 25792200 MWNISAGsSSEAILN X 89010; 46421 +PRKAA2 AMPKA2 P54646 human HOXB9 15417 P20615 Hoxb9 mouse T133 31087958 GELLKQGtPEYSLET Hox9_act X X +PRKAA2 AMPKA2 P54646 human PDHA1 5160 P08559 PDHA1 human S295 468391 RyHGHsMsDPGVsyR E1_dh X +PRKAA2 AMPKA2 P54646 human RAG1 19373 P15919 Rag1 mouse S528 28076402 PPLKNVSsRTDVGII RAG1 X X +PRKAA2 AMPKA2 P54646 human Raptor 57521 Q8N122 RPTOR human S792 2314600 DKMRRAssYSsLNSL X 2083; 89146 +PRKAA2 AMPKA2 P54646 human ARK2N 212163 Q8BH50 Ark2n mouse S67 485212 MELRRDssEsQLAst RNF111_N X +PRKAA2 AMPKA2 P54646 human SIRT1 23411 Q96EB6 SIRT1 human T344 25594500 GkLLRNYtQNIDTLE SIR2 X +PRKAA2 AMPKA2 P54646 human PINK1 65018 Q9BXM7 PINK1 human S495 396518801 ALLQREAsKRPSARV Pkinase X +PRKAA2 AMPKA2 P54646 human KLF10 21847 O89091 Klf10 mouse T188 25743268 DNSFRRRtHGNVEAT X X +PRKAA2 AMPKA2 P54646 human Restin 56430 Q922J3 Clip1 mouse S311 4769833 AsLKRsPsAssLSSM X +PRKAA2 AMPKA2 P54646 human DFNA5 1687 O60443 GSDME human T6 50777052 __MFAkAtRNFLREV Gasdermin X +PRKAA2 AMPKA2 P54646 human PHF2 5253 O75151 PHF2 human S655 3175945 kALRPPtsPGVFGAL X +PRKAA2 AMPKA2 P54646 human HAS2 3037 Q92819 HAS2 human T110 18122801 LQSVKRLtYPGIKVV X +PRKAA2 AMPKA2 P54646 human GSDMD 69146 Q9D8T2 Gsdmd mouse S46 1883583906 CLLNRKFsSSRFWKP Gasdermin X X +PRKAA2 AMPKA2 P54646 human FOXO3A 2309 O43524 FOXO3 human S555 20799903 RALsNsVsNMGLSES X +PRKAA2 AMPKA2 P54646 human HIPK2 28996 Q9H2X6 HIPK2 human T1114 28847906 APAALGStGTVAHLV X +PRKAA2 AMPKA2 P54646 human CHKA 1119 P35790 CHKA human S279 1876872804 kKLHKLLsYNLPLEL Choline_kinase X +PRKAA2 AMPKA2 P54646 human Kv2.1 25736 P15387 Kcnb1 rat S444 4714867 ERAKRNGsIVsMNMK X +PRKAA2 AMPKA2 P54646 human VASP 22323 P70460 Vasp mouse S317 469024 TtLPRMKssssVtTS X +PRKAA2 AMPKA2 P54646 human FOXO3A 2309 O43524 FOXO3 human T179 20799901 SSPDKRLtLSQIyEW Forkhead X +PRKAA2 AMPKA2 P54646 human FOXO3A 2309 O43524 FOXO3 human S588 20799904 QTLSDSLsGSSLYST X +PRKAA2 AMPKA2 P54646 human PROX1 5629 Q92786 PROX1 human S79 487308 KLLKRANsyEDAMMP X X +PRKAA2 AMPKA2 P54646 human PINK1 65018 Q9BXM7 PINK1 human S284 396518802 VLRAFTSsVPLLPGA Pkinase X +PRKAA2 AMPKA2 P54646 human IRSp53 10458 Q9UQB8 BAIAP2 human S366 468035 ktLPRsssMAAGLER X X +PRKAA2 AMPKA2 P54646 human FOXO3A 2309 O43524 FOXO3 human S413 12084437 GLMQRSSsFPYTTKG X 8174 +PRKAA2 AMPKA2 P54646 human AMPKA2 5563 P54646 PRKAA2 human T172 448026 sDGEFLRtsCGsPNy Pkinase X 2535; 2531; 5256; 50081; 74281 +PRKAA2 AMPKA2 P54646 human KLC4 89953 Q9NSK0 KLC4 human S590 454355 SNMKRAAsLNyLNQP X +PRKAA2 AMPKA2 P54646 human PAK2 5062 Q13177 PAK2 human S20 448298 APPVRMsstIFstGG X X 2607 +PRKAA2 AMPKA2 P54646 human IKKB 3551 O14920 IKBKB human S177 447492 AkELDQGsLCtsFVG Pkinase X X 2078; 2697; 2694; 14938; 92255; 36516; 36214 +PRKAA2 AMPKA2 P54646 human PGC-1 alpha 19017 O70343 Ppargc1a mouse T177 486319 NHTHRIRtNPAIVkT X +PRKAA2 AMPKA2 P54646 human REEP2 51308 Q9BRK0 REEP2 human S150 4765340 SEkLRsFsMQDLTLI X +PRKAA2 AMPKA2 P54646 human TBC1D1 23216 Q86TI0 TBC1D1 human T596 1247778 AFRRRANtLsHFPIE X +PRKAA2 AMPKA2 P54646 human FOXO3A 2309 O43524 FOXO3 human S399 20799902 DNItLPPsQPsPTGG X +PRKAA2 AMPKA2 P54646 human AS160 210789 Q8BYJ6 Tbc1d4 mouse S711 2226513 PSLHTSFsAPSFTAP X +PRKAA2 AMPKA2 P54646 human HDAC5 10014 Q9UQL6 HDAC5 human S259 447995 FPLRkTAsEPNLKVR X 3443 +PRKAA2 AMPKA2 P54646 human GLI1 2735 P08151 GLI1 human S102 41595602 LQTVIRTsPSSLVAF X X +PRKAA2 AMPKA2 P54646 human IKKB 3551 O14920 IKBKB human S181 447489 DQGsLCtsFVGTLQy Pkinase X X 2697; 2694; 14938; 92255; 36516; 36214 +PRKAA2 AMPKA2 P54646 human Kv2.1 25736 P15387 Kcnb1 rat S541 473556 SKMAKTQsQPILNTK Kv2channel X +PRKAA2 AMPKA2 P54646 human AP-2 alpha 7020 P05549 TFAP2A human S219 25581601 CSVPGRLsLLSsTsk TF_AP-2 X X +PRKAA2 AMPKA2 P54646 human AMPKA2 108079 Q8BRK8 Prkaa2 mouse T172 448026 sDGEFLRtsCGsPNY Pkinase X 2535; 2531; 5256; 50081; 74281 +PRKAA2 AMPKA2 P54646 human ACE2 70008 Q8R0I0 Ace2 mouse S680 1868162500 SDLKPRVsFYFFVTS Collectrin X X +PRKAA2 AMPKA2 P54646 human TBC1D1 23216 Q86TI0 TBC1D1 human S237 2103609 RPMRKsFsQPGLRSL X +PRKAA2 AMPKA2 P54646 human MFF 56947 Q9GZY8 MFF human S172 484865 GQLVRNDsLWHRsDs Miff X +PRKAA2 AMPKA2 P54646 human Myc 4609 P01106 MYC human S82 4967400 PLsPsRRsGLCsPSy Myc_N X X +PRKAA2 AMPKA2 P54646 human beclin 1 56208 O88597 Becn1 mouse S94 472002 MsTEsANsFTLIGEA X +PRKAA2 AMPKA2 P54646 human GLI1 2735 P08151 GLI1 human T1074 41595601 QRGSsGHtPPPsGPP X X 35875 +PRKAA2 AMPKA2 P54646 human ARMC10 83787 Q8N2F6 ARMC10 human S45 454558 LGIRSsKsAGALEEG X X +STK38L NDR2 Q9Y2H1 human IRF3 3661 Q14653 IRF3 human S396 449028 NtVDLHIsNsHPLsL X X 4947; 29047; 83611; 10327; 53539; 81093; 52270; 61166 +STK38L NDR2 Q9Y2H1 human NuaK1 9891 O60285 NUAK1 human T211 456032 QKDKFLQtFCGSPLY Pkinase X +STK38L NDR2 Q9Y2H1 human RAB3IP 117177 Q96QF0 RAB3IP human S288 4734219 KGHTRNKstSSAMSG X +STK38L NDR2 Q9Y2H1 human YAP1 10413 P46937 YAP1 human S127 448847 PQHVRAHssPAsLQL X 4911; 13008; 92367; 57706 +STK38L NDR2 Q9Y2H1 human ULK1 8408 O75385 ULK1 human S495 6220991 GVLARKMsLGGGRPY X X +STK38L NDR2 Q9Y2H1 human NDR2 23012 Q9Y2H1 STK38L human S282 460298 NRRQLAYstVGtPDy Pkinase X +CDC42BPB MRCKB Q9Y5S2 human MRCKB 9578 Q9Y5S2 CDC42BPB human T1108 1870421700 HVKVPKPtGVKKGWQ X +CDC42BPB MRCKB Q9Y5S2 human SIAH2 6478 O43255 SIAH2 human S6 25172963 __MsRPSstGPsANk X +CDC42BPB MRCKB Q9Y5S2 human SIAH2 6478 O43255 SIAH2 human T279 1872043500 RRLTWEAtPRSIHDG Sina X +Pim2 Pim2 Q62070 mouse NOTCH3 18131 Q61982 Notch3 mouse S1673 11179168 ARRKREHsTLWFPEG X +Wee2 WEE1B Q66JT0 mouse CDK1 12534 P11440 Cdk1 mouse Y15 447610 EKIGEGtyGVVyKGR Pkinase X 4539; 9111; 14566; 77897 +Prkaa1 AMPKA1 Q5EG47 mouse RAF1 5894 P04049 RAF1 human S621 447746 PKINRsAsEPsLHRA X +Prkaa1 AMPKA1 Q5EG47 mouse beclin 1 56208 O88597 Becn1 mouse S91 5473540 ARMMsTEsANsFTLI X 14717 +Prkaa1 AMPKA1 Q5EG47 mouse MFF iso4 75734 Q6PCP5-4 Mff mouse S129 470753 GRLKRERsMsENAVR Miff X +Prkaa1 AMPKA1 Q5EG47 mouse PDE4B 18578 Q8VBU5 Pde4b mouse S304 4765135 KKLMHsssLNNtSIS X +Prkaa1 AMPKA1 Q5EG47 mouse Raptor 74370 Q8K4Q0 Rptor mouse S722 2314601 PRLRsVssyGNIRAV X +Prkaa1 AMPKA1 Q5EG47 mouse TNNI3 21954 P48787 Tnni3 mouse S151 451822 tLRRVRIsADAMMQA Troponin X +Prkaa1 AMPKA1 Q5EG47 mouse H2B 319187 P10853 H2bc15 mouse S36 449903 RKRsRkEsysVyVyk Histone X +Prkaa1 AMPKA1 Q5EG47 mouse TBC1D1 57915 Q60949 Tbc1d1 mouse S700 2228807 KKLHssssVPNFLKF X 6929 +Prkaa1 AMPKA1 Q5EG47 mouse GABBR2 242425 Q80T41 Gabbr2 mouse S783 473060 VtsVNQAsTSRLEGL GBR2_CC X +Prkaa1 AMPKA1 Q5EG47 mouse TBC1D1 57915 Q60949 Tbc1d1 mouse S231 2103609 RPMRKsFsQPGLRSL X +Prkaa1 AMPKA1 Q5EG47 mouse TSC2 22084 Q61037 Tsc2 mouse S1388 450212 QPLSKssssPELQTL X 5584; 23402 +Prkaa1 AMPKA1 Q5EG47 mouse TBC1D1 57915 Q60949 Tbc1d1 mouse T499 2228808 NRAKRsLtEsLEsIL X +Prkaa1 AMPKA1 Q5EG47 mouse SIRT7 209011 Q8BKJ9 Sirt7 mouse T264 1874512900 EAAsKADtILCLGSS SIR2 X +Prkaa1 AMPKA1 Q5EG47 mouse TNNI3 29248 P23693 Tnni3 rat S151 451822 tLRRVRIsADAMMQA Troponin X +Prkaa1 AMPKA1 Q5EG47 mouse ACC1 107476 Q5SWU9 Acaca mouse S79 448292 FHMRSsMsGLHLVKQ X 3661; 11818; 42801 +Prkaa1 AMPKA1 Q5EG47 mouse EXO1 9156 Q9UQ84 EXO1 human S746 1240803 PGLYkSSsADsLStT X +Prkaa1 AMPKA1 Q5EG47 mouse TET2 214133 Q4JK59 Tet2 mouse S97 3202572 GGIKRtVsEPSLsGL X +Prkaa1 AMPKA1 Q5EG47 mouse GFAT 14583 P47856 Gfpt1 mouse S259 467935 CGLsRVDsttCLFPV X X +Prkaa1 AMPKA1 Q5EG47 mouse PAK2 224105 Q8CIN4 Pak2 mouse S20 448298 APPVRMSstIFSTGG X +Prkaa1 AMPKA1 Q5EG47 mouse PIKFYVE 18711 Q9Z1T6 Pikfyve mouse S307 457532 PARNRsAsItNLsLD X X +Prkaa1 AMPKA1 Q5EG47 mouse TBC1D1 57915 Q60949 Tbc1d1 mouse S621 2228806 RKLMRYHsVstETPH X +Prkaa1 AMPKA1 Q5EG47 mouse KLC1 16593 O88447 Klc1 mouse S520 468108 EsMEKRRsREsLNMD X +Prkaa1 AMPKA1 Q5EG47 mouse PIKFYVE 18711 Q9Z1T6 Pikfyve mouse S48 3887627 PFKSAYSsFVNLFRF X +Prkaa1 AMPKA1 Q5EG47 mouse NUDT14 66174 Q9D142 Nudt14 mouse T141 41294000 TDLRRVAtYMSGVGL NUDIX X +Prkaa1 AMPKA1 Q5EG47 mouse MFF iso4 75734 Q6PCP5-4 Mff mouse S146 484865 GQLVRNDsMyGIsNL Miff; Miff X 49281 +Prkaa1 AMPKA1 Q5EG47 mouse SMURF1 75788 Q9CUN6 Smurf1 mouse S148 27460454 DRIGGGGsVVDCRGL X X +Prkaa1 AMPKA1 Q5EG47 mouse PDLIM5 56376 Q8CI51 Pdlim5 mouse S177 38546304 TPLHLSAsGLHVSAN X +Prkaa1 AMPKA1 Q5EG47 mouse CK1E 1454 P49674 CSNK1E human S389 482888 rGAPANVsssDLtGR X +Prkaa1 AMPKA1 Q5EG47 mouse TNNI3 21954 P48787 Tnni3 mouse S23 448423 PAPVRRRssANyRAY Troponin-I_N X +Prkaa1 AMPKA1 Q5EG47 mouse Rb 19645 P13405 Rb1 mouse S804 448717 IyIsPLksPyKIsEG Rb_C X 9308; 8974; 4277; 40283; 8957; 8516; 11917; 41359; 75864 +Prkaa1 AMPKA1 Q5EG47 mouse KLF10 21847 O89091 Klf10 mouse T188 25743268 DNSFRRRtHGNVEAT X +Prkaa1 AMPKA1 Q5EG47 mouse TNNI3 29248 P23693 Tnni3 rat S23 448423 PAPVRRRssANYRAY Troponin-I_N X 4004 +Prkaa1 AMPKA1 Q5EG47 mouse Raptor 74370 Q8K4Q0 Rptor mouse S792 2314600 DKMRRVSsYSALNSL X 2083; 89146 +Prkaa1 AMPKA1 Q5EG47 mouse TBC1D17 233204 Q8BYH7 Tbc1d17 mouse S168 1873559800 RALLRVLsRYLLLAS PH_RBD X X +Prkaa1 AMPKA1 Q5EG47 mouse PNPLA2 66853 Q8BJ56 Pnpla2 mouse S406 473045 VELRRAQsLPsVPLS X +Prkaa1 AMPKA1 Q5EG47 mouse AS160 210789 Q8BYJ6 Tbc1d4 mouse S595 455920 RMRGRLGsMDsFERA X 8730 +Prkaa1 AMPKA1 Q5EG47 mouse TNNI3 29248 P23693 Tnni3 rat S24 448424 APVRRRssANYRAYA Troponin-I_N X 4004 +Prkaa1 AMPKA1 Q5EG47 mouse AS160 210789 Q8BYJ6 Tbc1d4 mouse S764 3175636 sstCsNEsLNAGGtP X +Prkaa1 AMPKA1 Q5EG47 mouse TBC1D1 57915 Q60949 Tbc1d1 mouse T253 2228805 DASLRSStFssFDND X +Prkaa1 AMPKA1 Q5EG47 mouse RAF1 5894 P04049 RAF1 human S259 447741 sQRQRststPNVHMV X 9421; 20011 +Prkaa1 AMPKA1 Q5EG47 mouse ZNF9 12785 P53996 Cnbp mouse T173 471955 GHLARECtIEAtA__ zf-CCHC X +Prkaa1 AMPKA1 Q5EG47 mouse MFF 75734 Q6PCP5 Mff mouse S129 470753 GRLKRERsMsENAVR Miff X +Prkaa1 AMPKA1 Q5EG47 mouse MFF 75734 Q6PCP5 Mff mouse S146 484865 GQLVRNDsIVtPsPP Miff X 49281 +Prkaa1 AMPKA1 Q5EG47 mouse AS160 210789 Q8BYJ6 Tbc1d4 mouse S711 2226513 PSLHTSFsAPSFTAP X +Prkaa1 AMPKA1 Q5EG47 mouse TBC1D1 57915 Q60949 Tbc1d1 mouse S660 2228809 PRLNPSAssPNFFKY X 6928 +Prkaa1 AMPKA1 Q5EG47 mouse TBC1D1 57915 Q60949 Tbc1d1 mouse T590 1247778 AFRRRANtLsHFPVE X +Prkaa1 AMPKA1 Q5EG47 mouse CYCS 13063 P62897 Cycs mouse T29 4710693 EKGGKHktGPNLHGL Cytochrom_C X +Prkaa1 AMPKA1 Q5EG47 mouse NKCC2 20495 P55014 Slc12a1 mouse S126 478420 GPkVNRPsLLEIHEQ AA_permease_N X X +Prkaa1 AMPKA1 Q5EG47 mouse GCKR 231103 Q91X44 Gckr mouse S481 1873175600 QKFQRELsTKWVLNT X X +Prkaa1 AMPKA1 Q5EG47 mouse H2B 3018 P33778 H2BC3 human S36 449903 RKRsRkEsysIyVyk Histone X +Prkaa1 AMPKA1 Q5EG47 mouse ULK1 22241 O70405 Ulk1 mouse S555 3176155 GLGCRLHsAPNLSDF X 5869 +Prkaa1 AMPKA1 Q5EG47 mouse girdin 108686 Q5SNZ0 Ccdc88a mouse S245 4725941 PGMKRTEsRQHLSVE X +Prkaa1 AMPKA1 Q5EG47 mouse AS160 210789 Q8BYJ6 Tbc1d4 mouse S348 455922 QPRRRHAsAPsHVQP PID X +Prkaa1 AMPKA1 Q5EG47 mouse HSL 16890 P54310 Lipe mouse S559 448804 ESMRRsVsEAALAQP X 4137 +Prkaa1 AMPKA1 Q5EG47 mouse MAP4 17758 P27546 Map4 mouse S914 1210622 SVRsKVGstENIKHQ Tubulin-binding X +Prkaa1 AMPKA1 Q5EG47 mouse AS160 210789 Q8BYJ6 Tbc1d4 mouse S577 455923 AKRsLtssLENIFSr X +CSNK1E CK1E P49674 human PER2 8864 O15055 PER2 human S662 449331 ALPGKAEsVAsLTsQ X X +CSNK1E CK1E P49674 human TDP-43 23435 Q13148 TARDBP human S379 3084615 NSYsGsNsGAAIGWG X X +CSNK1E CK1E P49674 human DVL3 1857 Q92997 DVL3 human S311 25736748 EINFENMsNDDAVRV PDZ X +CSNK1E CK1E P49674 human Snail1 6615 O95863 SNAI1 human S104 455881 GkGsQPPsPPsPAPs X +CSNK1E CK1E P49674 human E4BP4 395326 Q90Z72 NFIL3 chicken S182 452016 CISVIKHsPQSSMSD Vert_IL3-reg_TF X X +CSNK1E CK1E P49674 human TRPM4 54795 Q8TD43 TRPM4 human S839 36400700 GLSGGGGsLASGGPG Ion_trans X +CSNK1E CK1E P49674 human MCR 4306 P08235 NR3C2 human T800 1875398904 LPLEDQItLIQYSWM Hormone_recep X +CSNK1E CK1E P49674 human SRC-3 8202 Q9Y6Q9 NCOA3 human S102 4661900 VQkADVssTGQGVID X X +CSNK1E CK1E P49674 human CK1E 1454 P49674 CSNK1E human S323 453416 RMGQLrGsAtRALPP X +CSNK1E CK1E P49674 human DVL2 1856 O14641 DVL2 human S143 7320089 FHPNVSssHENLEPE Dishevelled X X +CSNK1E CK1E P49674 human TDP-43 23435 Q13148 TARDBP human S410 3084601 ssMDskssGWGM___ X X +CSNK1E CK1E P49674 human LRP6 4040 O75581 LRP6 human S1420 460717 YVVHGPAsVPLGYVP X +CSNK1E CK1E P49674 human SNCA 6622 P37840 SNCA human T64 1876998407 EktkEQVtNVGGAVV Synuclein X +CSNK1E CK1E P49674 human LRP6 4040 O75581 LRP6 human S1431 460718 GYVPHPSsLSGSLPG X +CSNK1E CK1E P49674 human YAP1 10413 P46937 YAP1 human S400 9764918 SRDEstDsGLsMsSy X X +CSNK1E CK1E P49674 human ZBED3 72114 Q9D0L1 Zbed3 mouse S111 6738702 MPCPPPPsPtMAAEG X +CSNK1E CK1E P49674 human CK1E 1454 P49674 CSNK1E human T407 453420 sRIPAsQtsVPFDHL X +CSNK1E CK1E P49674 human CDH1 999 P12830 CDH1 human S844 478354 GsGsEAAsLSsLNsS CADH_Y-type_LIR X +CSNK1E CK1E P49674 human TRAF3 7187 Q13114 TRAF3 human Y446 1869973806 SLYSQPFyTGYFGYK X +CSNK1E CK1E P49674 human TRAF3 7187 Q13114 TRAF3 human S349 8098598 QNWEEADsMkSSVEs X X +CSNK1E CK1E P49674 human RAD17 5884 O75943 RAD17 human T681 1868913302 EDyEsDGt_______ X +CSNK1E CK1E P49674 human DVL2 1856 O14641 DVL2 human T224 25538000 MSRFssStEQSsASR Dishevelled X X +CSNK1E CK1E P49674 human TDP-43 23435 Q13148 TARDBP human S403 3084617 GFNGGFGssMDskss X X +CSNK1E CK1E P49674 human SNCA 20617 O55042 Snca mouse T64 1876998407 EKtKEQVtNVGGAVV Synuclein X +CSNK1E CK1E P49674 human DVL3 1857 Q92997 DVL3 human S633 34668137 GPAASEHsHRsHHsL Dsh_C X +CSNK1E CK1E P49674 human DVL3 1857 Q92997 DVL3 human S639 34668134 HsHRsHHsLAssLRS Dsh_C X +CSNK1E CK1E P49674 human DVL3 1857 Q92997 DVL3 human S612 3830508 sDHttRssLRGPRER Dsh_C X +CSNK1E CK1E P49674 human PER1 18626 O35973 Per1 mouse S714 465536 ALANKAEsVVSVTSQ X X +CSNK1E CK1E P49674 human APC 324 P25054 APC human S1279 450136 sRCSSLssLSSAEDE APC_r X +CSNK1E CK1E P49674 human PER2 8864 O15055 PER2 human S668 20688400 EsVAsLTsQCsYSST X +CSNK1E CK1E P49674 human DVL1 13542 P51141 Dvl1 mouse S139 470073 DNETGTEsMVsHRRE Dishevelled X X +CSNK1E CK1E P49674 human CTNNB1 12387 Q02248 Ctnnb1 mouse S45 447488 GATtTAPsLsGkGNP X X 9565; 9564; 24710; 70034; 19807; 96727; 77605 +CSNK1E CK1E P49674 human TDP-43 23435 Q13148 TARDBP human S404 3084635 FNGGFGssMDskssG X X +CSNK1E CK1E P49674 human DVL3 1857 Q92997 DVL3 human S642 34668133 RsHHsLAssLRSHHT Dsh_C X +CSNK1E CK1E P49674 human CTNNB1 1499 P35222 CTNNB1 human S45 447488 GATtTAPsLsGkGNP X 9565; 9564; 24710; 70034; 19807; 96727; 77605 +CSNK1E CK1E P49674 human p53 22059 P02340 Tp53 mouse S12 447538 EEsQsDIsLELPLsQ P53_TAD X X +CSNK1E CK1E P49674 human CK1E 1454 P49674 CSNK1E human S408 453421 RIPAsQtsVPFDHLG X +CSNK1E CK1E P49674 human TRAF3 7187 Q13114 TRAF3 human Y116 1869973805 EILALQIyCRNESRG X +CSNK1E CK1E P49674 human DVL3 1857 Q92997 DVL3 human S636 34668132 ASEHsHRsHHsLAss Dsh_C X +CSNK1E CK1E P49674 human LRP6 4040 O75581 LRP6 human S1490 456289 AILNPPPsPAtERsH X 2568 +CSNK1E CK1E P49674 human 4E-BP1 1978 Q13541 EIF4EBP1 human T41 449366 ysttPGGtLFsttPG eIF_4EBP X X +CSNK1E CK1E P49674 human TDP-43 23435 Q13148 TARDBP human S409 3084616 GssMDskssGWGM__ X X +CSNK1E CK1E P49674 human PER2 8864 O15055 PER2 human S665 470017 GKAEsVAsLTsQCsY X +CSNK1E CK1E P49674 human ZBED3 72114 Q9D0L1 Zbed3 mouse T113 6738703 CPPPPsPtMAAEGDW X +CSNK1E CK1E P49674 human PER2 8864 O15055 PER2 human S480 50596800 PVPHSGSsGYGSLGS X X +CSNK1E CK1E P49674 human hnRNP P2 2521 P35637 FUS human S182 1878186704 GNYGQDQssMSSGGG X +CSNK1E CK1E P49674 human FMR1 14265 P35922 Fmr1 mouse S499 469583 NSEAsNAsETESDHR FXMRP1_C_core X +CSNK1E CK1E P49674 human CK1E 1454 P49674 CSNK1E human S368 449793 NtsPRAIsRVDRERK X +CSNK1E CK1E P49674 human YAP1 10413 P46937 YAP1 human S403 3190675 EstDsGLsMsSySVP X X +CSNK1E CK1E P49674 human DVL1 13542 P51141 Dvl1 mouse S142 470074 TGTEsMVsHRRERAR Dishevelled X X +CSNK1E CK1E P49674 human APC 324 P25054 APC human S1392 450135 sRCTsVSsLDsFESR APC_r X +CSNK1E CK1E P49674 human PRKD2 25865 Q9BZL6 PRKD2 human S244 1028300 sssSssAssyTGRPI X X +CSNK1E CK1E P49674 human CK1E 1454 P49674 CSNK1E human S405 449794 EVsRIPAsQtsVPFD X +CSNK1E CK1E P49674 human CTNND1 iso3 1500 O60716-3 CTNND1 human S268 450453 PQVRVGGssVDLHRF X +CSNK1E CK1E P49674 human DVL3 1857 Q92997 DVL3 human S611 34668129 EsDHttRssLRGPRE Dsh_C X +CSNK1E CK1E P49674 human DVL3 1857 Q92997 DVL3 human S643 34668102 sHHsLAssLRSHHTH Dsh_C X +CSNK1E CK1E P49674 human CK1E 1454 P49674 CSNK1E human T334 453418 ALPPGPPtGAtANRL X +CSNK1E CK1E P49674 human CTNNB1 12387 Q02248 Ctnnb1 mouse T41 447583 GIHsGATtTAPsLsG X X 9561; 9565; 4270; 13537; 41334; 60180 +CSNK1E CK1E P49674 human p53 22059 P02340 Tp53 mouse S7 448716 _MTAMEEsQsDIsLE X X +CSNK1E CK1E P49674 human 4E-BP1 1978 Q13541 EIF4EBP1 human T50 3195728 FsttPGGtRIIyDRk eIF_4EBP X X +CSNK1E CK1E P49674 human p53 22059 P02340 Tp53 mouse S9 447537 TAMEEsQsDIsLELP P53_TAD X X 9285 +CSNK1E CK1E P49674 human CTNND1 1500 O60716 CTNND1 human S268 450453 PQVRVGGssVDLHRF X +CSNK1E CK1E P49674 human CK1E 1454 P49674 CSNK1E human T337 453419 PGPPtGAtANRLrsA X +CSNK1E CK1E P49674 human DVL3 1857 Q92997 DVL3 human S280 34668101 DGGIYIGsIMkGGAV PDZ X +CSNK1E CK1E P49674 human Snail1 6615 O95863 SNAI1 human S107 455882 sQPPsPPsPAPssFS X +CSNK1E CK1E P49674 human FZD6 8323 O60353 FZD6 human S648 1275585104 sVSESARsEGRIsPK X +CSNK1E CK1E P49674 human CK1E 1454 P49674 CSNK1E human T325 453417 GQLrGsAtRALPPGP X +Prkdc DNAPK P97313 mouse FIS1 66437 Q9CQ92 Fis1 mouse T34 1876807204 AGsVSKStQFEYAWC Fis1_TPR_N X +Prkdc DNAPK P97313 mouse LKB1 20869 Q9WTK7 Stk11 mouse T366 448151 IEDGIIytQDFTVPG X +Prkdc DNAPK P97313 mouse LKB1 20869 Q9WTK7 Stk11 mouse S431 448147 sNKIRRLsACKQQ__ X 3482 +Mapkapk2 MAPKAPK2 P49138 mouse TTP 22695 P22893 Zfp36 mouse T249 3103927 CPSCRRsttPStIWG X +Mapkapk2 MAPKAPK2 P49138 mouse TTP 22695 P22893 Zfp36 mouse S316 451153 LPIFNRIsVsE____ X X +Mapkapk2 MAPKAPK2 P49138 mouse TTP 22695 P22893 Zfp36 mouse S52 451150 RLTGRSTsLVEGRsC X X +Mapkapk2 MAPKAPK2 P49138 mouse TFCP2L1 81879 Q3UNW5 Tfcp2l1 mouse S393 1875342302 LPQKQDDsGDNsLCV X +Mapkapk2 MAPKAPK2 P49138 mouse TTP 22695 P22893 Zfp36 mouse S176 3103925 QPHVLRQsIsFsGLP X +Mapkapk2 MAPKAPK2 P49138 mouse TTP 22695 P22893 Zfp36 mouse S264 2897405 PLGGLARsPsAHsLG X +Mapkapk2 MAPKAPK2 P49138 mouse RIPK1 19766 Q60855 Ripk1 mouse S336 209632700 LPPsRsNsEQPGSLH X X +Mapkapk2 MAPKAPK2 P49138 mouse MDM2 4193 Q00987 MDM2 human S166 448130 SsRRRAIsEtEENsD X 3521 +Mapkapk2 MAPKAPK2 P49138 mouse TTP 22695 P22893 Zfp36 mouse S178 451151 HVLRQsIsFsGLPsG X X +Mapkapk2 MAPKAPK2 P49138 mouse TTP 22695 P22893 Zfp36 mouse S58 457791 TsLVEGRsCGWVPPP X +Mapkapk2 MAPKAPK2 P49138 mouse HSP27 15507 P14602 Hspb1 mouse S15 448401 FsLLrsPsWEPFRDW X +Mapkapk2 MAPKAPK2 P49138 mouse HSPA1L 3305 P34931 HSPA1L human S241 1869383201 DFDNRLVsHFVEEFK HSP70 X +Mapkapk2 MAPKAPK2 P49138 mouse hnRNP A0 77134 Q9CX86 Hnrnpa0 mouse S84 449874 VELKRAVsREDsARP X X +Mapkapk2 MAPKAPK2 P49138 mouse TFCP2L1 81879 Q3UNW5 Tfcp2l1 mouse S397 1875342304 QDDsGDNsLCVyHAI X +Mapkapk2 MAPKAPK2 P49138 mouse TTP 22695 P22893 Zfp36 mouse S266 3103920 GGLARsPsAHsLGsD X +Mapkapk2 MAPKAPK2 P49138 mouse TTP 22695 P22893 Zfp36 mouse S85 2295101 ELsPsPtsPtATPTT X +Mapkapk2 MAPKAPK2 P49138 mouse C/EBP-beta 12608 P28033 Cebpb mouse T188 447878 sSssPPGtPSPADAK X X 3084 +Mapkapk2 MAPKAPK2 P49138 mouse TTP 22695 P22893 Zfp36 mouse T84 457793 PELsPsPtsPtATPT X +Mapkapk2 MAPKAPK2 P49138 mouse TTP 22695 P22893 Zfp36 mouse S105 3103926 TELCRTYsESGRCRY zf-CCCH X +Mapkapk2 MAPKAPK2 P49138 mouse TTP 22695 P22893 Zfp36 mouse T250 451152 PSCRRsttPStIWGP X X +Mapkapk2 MAPKAPK2 P49138 mouse UBE2J1 56228 Q9JJZ4 Ube2j1 mouse S184 465537 KELARQIsFKAEVNS X X +Mapkapk2 MAPKAPK2 P49138 mouse RIPK1 19766 Q60855 Ripk1 mouse S321 468644 PVLQRMFsLQHDCVP X X 83613; 38662 +CAMK1 CAMK1A Q14012 human p27Kip1 12576 P46414 Cdkn1b mouse T170 6058800 QNkRANRtEENVsDG X +CAMK1 CAMK1A Q14012 human QIK 315649 Q3LRT3 Sik2 rat T484 478056 RSGQRRHtLSEVTNQ X X +CAMK1 CAMK1A Q14012 human TH 25085 P04177 Th rat S19 448542 KGFRRAVsEQDAKQA TOH_N X +CAMK1 CAMK1A Q14012 human MARK2 60328 O08679 Mark2 rat T294 26573805 LNPSKRGtLEQIMKD Pkinase X +CAMK1 CAMK1A Q14012 human PKLR 24651 P12928 Pklr rat T53 451507 QLtQELGtAFFQQQQ X +CAMK1 CAMK1A Q14012 human PKLR iso2 24651 P12928-2 Pklr rat T17 451506 RAsVAQLtQELGtAF X +CAMK1 CAMK1A Q14012 human RPS19 P17074 Rps19 rat S59 7113803 WFYTRAAsTARHLYL Ribosomal_S19e X +CAMK1 CAMK1A Q14012 human HDAC5 10014 Q9UQL6 HDAC5 human S498 447996 RPLSRtQsSPLPQsP X 3424 +CAMK1 CAMK1A Q14012 human ARHGEF7 114559 O55043 Arhgef7 rat S516 455215 RKPERKPsDEEFAVR RhoGEF67_u2 X X +CAMK1 CAMK1A Q14012 human HDAC7 56233 Q8C2B3 Hdac7 mouse S479 452459 RPLsRtQssPAAPVS X 3424 +CAMK1 CAMK1A Q14012 human GCM1 8521 Q9NP62 GCM1 human T174 20745203 RAMKKVNtAPssVSL X +CAMK1 CAMK1A Q14012 human HDAC7 56233 Q8C2B3 Hdac7 mouse S344 455621 RPLNRtRsEPLPPsA X +CAMK1 CAMK1A Q14012 human RYR1 100009540 P11716 RYR1 rabbit S2843 451818 KKKTRKIsQTAQTYD X +CAMK1 CAMK1A Q14012 human PKLR iso2 24651 P12928-2 Pklr rat T22 451507 QLtQELGtAFFQQQQ X +CAMK1 CAMK1A Q14012 human p27Kip1 1027 P46527 CDKN1B human T157 448645 GIRkrPAtDDSSTQN X X +CAMK1 CAMK1A Q14012 human p27Kip1 1027 P46527 CDKN1B human T198 448781 PGLRRRQt_______ X X +CAMK1 CAMK1A Q14012 human GCM1 8521 Q9NP62 GCM1 human S177 20745202 KKVNtAPssVSLSLK X +CAMK1 CAMK1A Q14012 human NUMB 29419 Q2LC84 Numb rat S294 470030 SPFKRQLsLRINELP NumbF X +CAMK1 CAMK1A Q14012 human PKLR 24651 P12928 Pklr rat T48 451506 RASVAQLtQELGtAF X +CAMK1 CAMK1A Q14012 human MARK2 60328 O08679 Mark2 rat S92 26573804 DKTQLNssSLQKLFR Pkinase X +CAMK1 CAMK1A Q14012 human GCM1 8521 Q9NP62 GCM1 human S47 20745200 YAKHIYSsEDKNAQR GCM X X +CAMK1 CAMK1A Q14012 human EIF4G3 8672 O43432 EIF4G3 human S1156 2915400 NTFMRGGssKDLLDN X +CAMK1 CAMK1A Q14012 human SIK 59329 Q9R1U5 Sik1 rat T322 990311 LGIDRQRtVESLQNS X +CAMK1 CAMK1A Q14012 human TH 25085 P04177 Th rat S40 448545 RFIGRRQsLIEDARK TOH_N X 2791 +CAMK1 CAMK1A Q14012 human NUMB 29419 Q2LC84 Numb rat S275 456490 EQLARQGsFRGFPAL NumbF X 4140; 9878 +CAMK1 CAMK1A Q14012 human MRLC1 10398 P24844 MYL9 human S20 1863500 KRPQRAtsNVFAMFD X 3674; 3671; 3675; 95777 +CAMK1 CAMK1A Q14012 human GCM1 8521 Q9NP62 GCM1 human S178 20745201 KVNtAPssVSLSLKG X +CAMK1 CAMK1A Q14012 human GCM1 8521 Q9NP62 GCM1 human S269 18788303 LYEKRKLsSSRTYsS X +CAMK1 CAMK1A Q14012 human HSL 3991 Q05469 LIPE human S855 448804 EPMRRsVsEAALAQP X 4137 +CAMK1 CAMK1A Q14012 human CAMK2A iso2 815 Q9UQM7-2 CAMK2A human S332 3143902 DGVKkRKssssVQLM X +CAMK1 CAMK1A Q14012 human PPME1 51400 Q9Y570 PPME1 human S15 476688 MHLGRLPsrPPLPGs X X +CAMK1 CAMK1A Q14012 human HDAC5 10014 Q9UQL6 HDAC5 human S259 447995 FPLRkTAsEPNLKVR X 3443 +CAMK1 CAMK1A Q14012 human DRP1 114114 O35303 Dnm1l rat S656 483971 VPVARKLsAREQRDC X X 4867; 6319 +CAMK1 CAMK1A Q14012 human MARK2 60328 O08679 Mark2 rat S91 26573803 IDKTQLNssSLQKLF Pkinase X +CAMK1 CAMK1A Q14012 human RPS19 6223 P39019 RPS19 human S59 7113803 WFytrAAsTARHLYL Ribosomal_S19e X +CAMK1 CAMK1A Q14012 human p27Kip1 12576 P46414 Cdkn1b mouse T197 448781 KPGLRRQt_______ X +CAMK1 CAMK1A Q14012 human RPS19 20085 Q9CZX8 Rps19 mouse S59 7113803 WFYTRAAsTARHLYL Ribosomal_S19e X +CAMK1 CAMK1A Q14012 human HDAC7 56233 Q8C2B3 Hdac7 mouse S178 455620 FPLRKTVsEPNLKLR X 3443 +CAMK1 CAMK1A Q14012 human HDAC9 9734 Q9UKV0 HDAC9 human S220 448485 FPLRkTAsEPNLKVR X +CAMK1 CAMK1A Q14012 human HDAC9 9734 Q9UKV0 HDAC9 human S451 448486 RPLNRtQsAPLPQST X +Rps6kb1 p70S6K Q8BSK8 mouse IRS1 3667 P35568 IRS1 human S636 447506 sGDyMPMsPKsVSAP X 2388 +Rps6kb1 p70S6K Q8BSK8 mouse ER-alpha 13982 P19785 Esr1 mouse S171 448102 NGRERLSsSNEKGNM Oest_recep X +Rps6kb1 p70S6K Q8BSK8 mouse CREM 12916 P27699 Crem mouse S133 448412 EILSRRPsYRKILNE pKID X X 4095; 14228; 14001 +Rps6kb1 p70S6K Q8BSK8 mouse IRS1 3667 P35568 IRS1 human S307 450190 TRRsRtEsItAtsPA X 2384; 2491 +Rps6kb1 p70S6K Q8BSK8 mouse GluR1 14799 P23818 Gria1 mouse T858 3362100 NEAIRtstLPRNsGA X +Rps6kb1 p70S6K Q8BSK8 mouse IRS1 3667 P35568 IRS1 human S639 447507 yMPMsPKsVSAPQQI X 2388 +Rps6kb1 p70S6K Q8BSK8 mouse S6 20104 P62754 Rps6 mouse S235 448092 IAKRRRLssLRAsts X X 5006; 4856; 4857; 4858; 4851; 4803; 2211; 3945; 3985; 5316; 4854; 8520; 48319; 40643; 9865; 38573; 14733; 27036; 34411; 62016; 62788; 81736; 97935; 99457; 15448 +Rps6kb1 p70S6K Q8BSK8 mouse MDM2 17246 P23804 Mdm2 mouse S163 448130 SSRRRsIsEtEENTD X 3521 +Rps6kb1 p70S6K Q8BSK8 mouse FMR1 14265 P35922 Fmr1 mouse S499 469583 NSEAsNAsETESDHR FXMRP1_C_core X X +Rps6kb1 p70S6K Q8BSK8 mouse IRS1 3667 P35568 IRS1 human S312 447558 tEsItAtsPAsMVGG X 2381 +Rps6kb1 p70S6K Q8BSK8 mouse GSK3B 56637 Q9WV60 Gsk3b mouse S9 449111 SGRPRttsFAEsCKP X 9336; 9331; 9327; 9323; 9322; 9325; 5558; 8566; 79774; 8466; 25462; 14026; 14332; 14310; 14630 +Rps6kb1 p70S6K Q8BSK8 mouse CCT2 12461 P80314 Cct2 mouse S260 472352 GsRVRVDsTAKVAEI Cpn60_TCP1 X X +Rps6kb1 p70S6K Q8BSK8 mouse LKB1 20869 Q9WTK7 Stk11 mouse S431 448147 sNKIRRLsACKQQ__ X 3482 +Rps6kb1 p70S6K Q8BSK8 mouse IRS1 25467 P35570 Irs1 rat S1100 453434 GCRRRHssEtFSAPt X 2385 +Rps6kb1 p70S6K Q8BSK8 mouse p14ARF 12578 Q64364 Cdkn2a mouse S71 50440900 GDDDGQRsRSSSSAQ X X +Rps6kb1 p70S6K Q8BSK8 mouse DNAJC2 22791 P54103 Dnajc2 mouse S47 469782 KRRNRNAstsFQELE X 12397 +Rps6kb1 p70S6K Q8BSK8 mouse S6 20104 P62754 Rps6 mouse S236 448093 AKRRRLssLRAstsK X X 5006; 4856; 4857; 4858; 4851; 4803; 2211; 3945; 3985; 5316; 4854; 8520; 48319; 40643; 9865; 38573; 14733; 27036; 34411; 62016; 62788; 81736; 97935; 99457; 15448 +Rps6kb1 p70S6K Q8BSK8 mouse IRS1 3667 P35568 IRS1 human S616 447562 DDGyMPMsPGVAPVP X 3193; 2386; 3203 +TNNI3K TNNI3K Q59H18 human TNNI3 29248 P23693 Tnni3 rat S43 450690 AKKKSKIsAsRKLQL X +TNNI3K TNNI3K Q59H18 human TNNI3 29248 P23693 Tnni3 rat T144 451483 RGKFkRPtLRRVRIs Troponin X +CKM CKM P00565 chicken CKM 396507 P00565 CKM chicken S285 451823 GYILtCPsNLGtGLR ATP-gua_Ptrans X +CKM CKM P00565 chicken CKM 396507 P00565 CKM chicken T282 451820 EHLGYILtCPsNLGt ATP-gua_Ptrans X +CKM CKM P00565 chicken CKM 396507 P00565 CKM chicken T289 451821 tCPsNLGtGLRGGVH ATP-gua_Ptrans X +BCR/ABL BCR-ABL1 A9UF07 human SMAD4 4089 Q13485 SMAD4 human Y301 1881244702 MPPHPGHyWPVHNEL X +BCR/ABL BCR-ABL1 A9UF07 human RAD51 5888 Q06609 RAD51 human Y315 448324 EtRICKIyDSPCLPE Rad51 X +BCR/ABL BCR-ABL1 A9UF07 human Bcr 613 P11274 BCR human Y177 447792 ADAEKPFyVNVEFHH X 3901 +BCR/ABL BCR-ABL1 A9UF07 human Bcr 613 P11274 BCR human Y360 447796 VsPsPttyRMFRDKS X X +BCR/ABL BCR-ABL1 A9UF07 human JAK2 16452 Q62120 Jak2 mouse Y1008 448408 LPQDKEyyKVKEPGE PK_Tyr_Ser-Thr X 3771; 3776; 8082; 66245; 32901 +BCR/ABL BCR-ABL1 A9UF07 human GRB2 2885 P62993 GRB2 human Y209 448512 TGMFPRNyVtPVNrN X +BCR/ABL BCR-ABL1 A9UF07 human Abl 25 P00519 ABL1 human Y257 450300 GGQyGEVyEGVWKKy PK_Tyr_Ser-Thr X +BCR/ABL BCR-ABL1 A9UF07 human RAD52 5893 P43351 RAD52 human Y104 449061 DLNNGKFyVGVCAFV Rad52_Rad22 X +BCR/ABL BCR-ABL1 A9UF07 human SMAD4 4089 Q13485 SMAD4 human Y195 1881244700 NRASTETyStPALLA X +BCR/ABL BCR-ABL1 A9UF07 human CRKL 1399 P46109 CRKL human Y207 447954 IPEPAHAyAQPQttt X X 3181; 34940; 94358 +BCR/ABL BCR-ABL1 A9UF07 human Bcr 613 P11274 BCR human Y328 447795 FEDCGGGytPDCSSN X +BCR/ABL BCR-ABL1 A9UF07 human Abl 25 P00519 ABL1 human Y253 450301 HKLGGGQyGEVyEGV PK_Tyr_Ser-Thr X +BCR/ABL BCR-ABL1 A9UF07 human CDV-3 321022 Q4VAA2 Cdv3 mouse Y120 450290 FEQREVDySGLRVQA CDV3 X +BCR/ABL BCR-ABL1 A9UF07 human RHOA 387 P61586 RHOA human Y66 475231 DtAGQEDyDRLRPLS Ras X +BCR/ABL BCR-ABL1 A9UF07 human JAK2 16452 Q62120 Jak2 mouse Y1007 448407 VLPQDKEyyKVKEPG PK_Tyr_Ser-Thr X X 3771; 3776; 4406; 66245; 32901 +BCR/ABL BCR-ABL1 A9UF07 human CHCHD2 51142 Q9Y6H1 CHCHD2 human Y99 62463400 PARPDITyQEPQGTQ X +BCR/ABL BCR-ABL1 A9UF07 human Lasp-1 3927 Q14847 LASP1 human Y171 451675 IPtsAPVyQQPQQQP X +BCR/ABL BCR-ABL1 A9UF07 human Bcr 613 P11274 BCR human Y283 447794 yQPyQsIyVGGMMEG X +BCR/ABL BCR-ABL1 A9UF07 human RHOA 387 P61586 RHOA human Y34 473955 kDQFPEVyVPTVFEN Ras X +BCR/ABL BCR-ABL1 A9UF07 human Abl 25 P00519 ABL1 human Y232 450302 VyGVsPNyDKWEMER X +BCR/ABL BCR-ABL1 A9UF07 human SMAD4 4089 Q13485 SMAD4 human Y322 1881244704 SNHPAPEyWCSIAYF X +YES1 Yes P07947 human YAP1 10413 P46937 YAP1 human Y407 473004 sGLsMsSySVPRtPD X X +YES1 Yes P07947 human CDC37 11140 Q16543 CDC37 human Y4 34490407 ____MVDysVWDHIE CDC37_N X X +YES1 Yes P07947 human NRF2 4780 Q16236 NFE2L2 human Y576 460703 RDEDGkPysPSEYSL X +YES1 Yes P07947 human FAK 5747 Q05397 PTK2 human Y925 447966 DRsNDkVyENVtGLV Focal_AT X 3284 +YES1 Yes P07947 human ANXA2 302 P07355 ANXA2 human Y24 449483 HstPPsAyGsVkAyt X X +YES1 Yes P07947 human NPHS1 4868 O60500 NPHS1 human Y1193 469565 SGAWGPLyDEVQMGP X +YES1 Yes P07947 human YAP1 10413 P46937 YAP1 human Y391 15565111 PFLNsGtyHSRDEst X X +YES1 Yes P07947 human HER2 2064 P04626 ERBB2 human Y877 448694 LDIDEtEyHADGGkV PK_Tyr_Ser-Thr X 2241 +YES1 Yes P07947 human DLC1 50768 Q9R0Z9 Dlc1 mouse Y702 1869008601 SAEDNVNyEGQSAYD RhoGAP X +YES1 Yes P07947 human TAZ 25937 Q9GZV5 WWTR1 human Y305 1876136800 PFLNGGPyHsREQst X X +YES1 Yes P07947 human FAK 5747 Q05397 PTK2 human Y861 447965 PIGNQHIyQPVGKPD X +YES1 Yes P07947 human WBP2 23558 Q969T9 WBP2 human Y231 464521 AEAAASAyyNPGNPH X +YES1 Yes P07947 human DLC1 50768 Q9R0Z9 Dlc1 mouse Y452 1869008602 NVPGSILySSSGELA X +YES1 Yes P07947 human p27Kip1 1027 P46527 CDKN1B human Y89 456819 GsLPEFyyRPPRPPK X +YES1 Yes P07947 human CRMP-2 1808 Q16555 DPYSL2 human Y479 18833900 kPFPDFVyKRIKARS X +YES1 Yes P07947 human WBP2 23558 Q969T9 WBP2 human Y192 20612405 MMDGAMGyVQPPPPP X +YES1 Yes P07947 human Ets-1 2113 P14921 ETS1 human Y283 449428 sLQRVPsyDsFDsED Ets1_N_flank X +YES1 Yes P07947 human 5-LO 240 P09917 ALOX5 human Y54 33670310 ERGAVDSyDVTVDEE PLAT X +YES1 Yes P07947 human p27Kip1 1027 P46527 CDKN1B human Y88 456818 kGsLPEFyyRPPRPP X +YES1 Yes P07947 human 5-LO 240 P09917 ALOX5 human Y446 33670311 RAMKDLtyAsLCFPE Lipoxygenase X +YES1 Yes P07947 human p27Kip1 1027 P46527 CDKN1B human Y74 475060 HkPLEGkyEWQEVEk CDI X +YES1 Yes P07947 human CDC37 11140 Q16543 CDC37 human Y298 451691 GLDPVEVyEsLPEEL CDC37_C X X +YES1 Yes P07947 human CDK4 1019 P11802 CDK4 human Y17 455500 AEIGVGAyGTVYkAR Pkinase X X +YES1 Yes P07947 human 5-LO 240 P09917 ALOX5 human Y43 33670312 HLLDKPFyNDFERGA PLAT X +YES1 Yes P07947 human SOCS1 8651 O15524 SOCS1 human Y80 1868450203 LLDACGFyWGPLSVH SH2 X +YES1 Yes P07947 human GLO1 2739 Q04760 GLO1 human Y136 463450 GIAVPDVysACkRFE Glyoxalase X X +Akt1 Akt1 P31750 mouse BIM 10018 O43521 BCL2L11 human S87 458219 FIFMRRSsLLSRSss X +Akt1 Akt1 P31750 mouse BAD 12015 Q61337 Bad mouse S155 447863 GRELRRMsDEFEGsF Bcl-2_BAD X X 9297 +Akt1 Akt1 P31750 mouse PAK1 18479 O88643 Pak1 mouse S21 448174 APPMRNTsTMIGAGS X +Akt1 Akt1 P31750 mouse ERR3 26381 P62509 Esrrg mouse S179 36400701 ITKRRRKsCQACRFM zf-C4 X +Akt1 Akt1 P31750 mouse BACH2 12014 P97303 Bach2 mouse S520 470117 EtRTRtsssCssYsY X +Akt1 Akt1 P31750 mouse QIK 235344 Q8CFH6 Sik2 mouse S358 487501 DGRQRRPstIAEQTV X +Akt1 Akt1 P31750 mouse AMPKA1 105787 Q5EG47 Prkaa1 mouse S496 450431 AtPQRsGsIsNYRsC AdenylateSensor X 4185; 4184; 2537 +Akt1 Akt1 P31750 mouse DLK 26404 Q60700 Map3k12 mouse S584 40416401 KTRHRKAsAKGsCGD X +Akt1 Akt1 P31750 mouse CSK 12988 P41241 Csk mouse S284 23096469 YLRSRGRsVLGGDCL PK_Tyr_Ser-Thr X +Akt1 Akt1 P31750 mouse CDC25B 12531 P30306 Cdc25b mouse S351 452008 VQSKRRKsVtPLEEQ M-inducer_phosp X +Akt1 Akt1 P31750 mouse NDRG2 29811 Q9QYG0 Ndrg2 mouse T348 451009 GsRsRsRtLsQssEs X +Akt1 Akt1 P31750 mouse PRAS40 84335 Q96B36 AKT1S1 human T246 470067 LPRPRLNtsDFQkLK PRAS X 2640; 2997; 32263; 13175; 60202 +Akt1 Akt1 P31750 mouse FOXO1A 56458 Q9R1E0 Foxo1 mouse S253 448075 sPRRRAAsMDNNSkF X X 9461; 84192 +Akt1 Akt1 P31750 mouse SHP-1 15170 P29351 Ptpn6 mouse T394 23144271 TAEYkLRtLQISPLD Y_phosphatase X +Akt1 Akt1 P31750 mouse AS160 210789 Q8BYJ6 Tbc1d4 mouse T649 455921 QFRRRAHtFsHPPSS X X 4288; 8881 +Akt1 Akt1 P31750 mouse PDE3B 18576 Q61409 Pde3b mouse S273 447699 VIRPRRRssCVsLGE X X +Akt1 Akt1 P31750 mouse ULK1 22241 O70405 Ulk1 mouse S774 4699305 STRTRMFsVGsSSsL X +Akt1 Akt1 P31750 mouse DLK 26404 Q60700 Map3k12 mouse T659 40416400 GARGRGAtGGARDPG X +Akt1 Akt1 P31750 mouse HCN2 15166 O88703 Hcn2 mouse S861 1871246002 SARSRLSsNL_____ X +Akt1 Akt1 P31750 mouse ACLY 104112 Q91V92 Acly mouse S455 448631 PAPsRtAsFsEsRAD X 4331 +Akt1 Akt1 P31750 mouse PIKFYVE 18711 Q9Z1T6 Pikfyve mouse S307 457532 PARNRsAsItNLsLD X +Akt1 Akt1 P31750 mouse TSC2 22084 Q61037 Tsc2 mouse S939 448501 SFRARSTsLNERPKs X 3615 +Akt1 Akt1 P31750 mouse FOXO1A 56458 Q9R1E0 Foxo1 mouse S316 449113 TFRPRTSsNAstISG X 2486 +Akt1 Akt1 P31750 mouse PIKFYVE 18711 Q9Z1T6 Pikfyve mouse S48 3887627 PFKSAYSsFVNLFRF X +Akt1 Akt1 P31750 mouse RAF1 110157 Q99N57 Raf1 mouse S259 447741 SQRQRStsTPNVHMV X 9421; 20011 +Akt1 Akt1 P31750 mouse PANX3 208098 Q8CEG0 Panx3 mouse S68 1869686803 GSPISCFsPSNFSVR Innexin X +Akt1 Akt1 P31750 mouse H3 iso3 15081 P84244 H3f3b mouse S10 455676 tKQTARksTGGkAPR Histone X 9701; 9711; 9706; 3465; 3642; 3377; 3475; 3458; 5764; 47398; 8481; 8552; 53348; 29237; 66065; 43185; 64522; 52725 +Akt1 Akt1 P31750 mouse MKK4 26398 P47809 Map2k4 mouse S78 447655 IERLRTHsIESsGKL X 9155 +Akt1 Akt1 P31750 mouse GRB10 14783 Q60760 Grb10 mouse S455 455333 NAPMRsVsENsLVAM BPS X +Akt1 Akt1 P31750 mouse CTNNB1 12387 Q02248 Ctnnb1 mouse S552 472273 QDTQRRtsMGGtQQQ X 9566; 5651 +Akt1 Akt1 P31750 mouse Bcl-3 602 P20749 BCL3 human S41 27444668 kRPLRAPsPEPAAPR X +Akt1 Akt1 P31750 mouse GSK3A 606496 Q2NL51 Gsk3a mouse S21 448584 sGRARtssFAEPGGG X 9337; 9316; 9331; 9327; 8452; 8566 +Akt1 Akt1 P31750 mouse E2A iso2 21423 P15806-2 Tcf3 mouse S527 483180 VPRtRtsstDEVLsL X +Akt1 Akt1 P31750 mouse BAD 12015 Q61337 Bad mouse S112 447860 ETRsRHssyPAGtEE Bcl-2_BAD X X 9291; 5284; 9296; 5193; 11865; 94223 +Akt1 Akt1 P31750 mouse AS160 210789 Q8BYJ6 Tbc1d4 mouse S595 455920 RMRGRLGsMDsFERA X 8730 +Akt1 Akt1 P31750 mouse Akt1 11651 P31750 Akt1 mouse S473 447855 RPHFPQFsysAsGtA Pkinase_C X X 9271; 3787; 4060; 4051; 5102; 4058; 2336; 2337; 4075; 4070; 5012; 4071; 92982; 5315; 9563; 9018; 12694; 52240; 11962; 15116; 88106; 26580; 68035; 31957; 23430; 20235 +Akt1 Akt1 P31750 mouse MDM2 17246 P23804 Mdm2 mouse S163 448130 SSRRRsIsEtEENTD X 3521 +Akt1 Akt1 P31750 mouse GSK3B 56637 Q9WV60 Gsk3b mouse S9 449111 SGRPRttsFAEsCKP X X 9336; 9331; 9327; 9323; 9322; 9325; 5558; 8566; 79774; 8466; 25462; 14026; 14332; 14310; 14630 +Akt1 Akt1 P31750 mouse FOXO3A 56484 Q9WVH4 Foxo3 mouse T32 448602 QSRPRSCtWPLQRPE X 9464 +Akt1 Akt1 P31750 mouse lamin A/C 60374 P48679 Lmna rat S404 478681 RSRGRAssHssQSQG X +Akt1 Akt1 P31750 mouse PERK 13666 Q9Z2B5 Eif2ak3 mouse T799 11073906 YTRSREGtSSSIVFE X +Akt1 Akt1 P31750 mouse FOXO1A 56458 Q9R1E0 Foxo1 mouse T24 448560 LPRQRSCtWPLPRPE X X 2599; 9464 +Akt1 Akt1 P31750 mouse TBC1D1 57915 Q60949 Tbc1d1 mouse T590 1247778 AFRRRANtLsHFPVE X +Akt1 Akt1 P31750 mouse IRS2 29376 F1MAL5 Irs2 rat S574 483923 GLRKRTYsLTTPARQ X +Akt1 Akt1 P31750 mouse BAD 12015 Q61337 Bad mouse S136 447862 PFRGRsRsAPPNLWA Bcl-2_BAD X X 9295; 5286; 4366 +Akt1 Akt1 P31750 mouse LGMN 19141 O89017 Lgmn mouse T324 23121345 LKRKLLRtNDVKESQ X +Akt1 Akt1 P31750 mouse FOXO3A 2309 O43524 FOXO3 human S253 449108 APRRRAVsMDNSNkY X 9466; 13129 +Akt1 Akt1 P31750 mouse AS160 210789 Q8BYJ6 Tbc1d4 mouse S324 455925 EFRsRCssVTGVMQK PID X 8619 +Akt1 Akt1 P31750 mouse PHB 18673 P67778 Phb1 mouse T258 11139253 LSRSRNItyLPAGQs X +Akt1 Akt1 P31750 mouse CS 12974 Q9CZU6 Cs mouse S225 4774521 RNLYREGssIGAIDs Citrate_synt X +Akt1 Akt1 P31750 mouse STX7 53331 O70439 Stx7 mouse S126 468881 VARVRAssRVsGGFP X +Akt1 Akt1 P31750 mouse Nur77 3164 P22736 NR4A1 human S351 447942 GRRGRLPsKPKQPPD X 5095 +Akt1 Akt1 P31750 mouse TFEB 21425 Q9R210 Tfeb mouse S466 4785142 KAssRRssFsMEEGD DUF3371 X +Akt1 Akt1 P31750 mouse PAK6 56924 Q9NQU5 PAK6 human S113 5208141 TSRRRAQsLGLLGDE X +Akt1 Akt1 P31750 mouse GATA1 14460 P17679 Gata1 mouse S310 451231 QTRNRkAsGkGKKkR X +Akt1 Akt1 P31750 mouse S6 20104 P62754 Rps6 mouse S236 448093 AKRRRLssLRAstsK X 5006; 4856; 4857; 4858; 4851; 4803; 2211; 3945; 3985; 5316; 4854; 8520; 48319; 40643; 9865; 38573; 14733; 27036; 34411; 62016; 62788; 81736; 97935; 99457; 15448 +Akt1 Akt1 P31750 mouse GLI2 14633 Q0VGT2 Gli2 mouse S230 2677401 LSrKrALsIsPLSDA X X +Akt1 Akt1 P31750 mouse girdin 108686 Q5SNZ0 Ccdc88a mouse S1417 456477 INRERQKsLtLtPTR X X +Prkcb PKCB iso2 P68404-2 mouse TNNI3 21954 P48787 Tnni3 mouse S45 450691 KKSKIsAsRKLQLkT X +Prkcb PKCB iso2 P68404-2 mouse TNNI3 21954 P48787 Tnni3 mouse S23 448423 PAPVRRRssANyRAY Troponin-I_N X +Prkcb PKCB iso2 P68404-2 mouse IRS2 384783 P81122 Irs2 mouse S303 3217341 EFRPRsKsQssGSSA X X +Prkcb PKCB iso2 P68404-2 mouse TNNI3 21954 P48787 Tnni3 mouse T144 451483 RGKFKRPtLRRVRIs Troponin X +Prkcb PKCB iso2 P68404-2 mouse IRS2 384783 P81122 Irs2 mouse S675 472256 sDDyMPMsPtSVSAP X X +Prkcb PKCB iso2 P68404-2 mouse PKCB iso2 18751 P68404-2 Prkcb mouse S660 1869073011 QsEFEGFsFVNsEFL Pkinase_C X +Prkcb PKCB iso2 P68404-2 mouse TNNI3 21954 P48787 Tnni3 mouse S43 450690 AkKKSKIsAsRKLQL X +Prkcb PKCB iso2 P68404-2 mouse TNNI3 21954 P48787 Tnni3 mouse S24 448424 APVRRRssANyRAYA Troponin-I_N X +Src Src P05480 mouse PRDX1 18477 P35700 Prdx1 mouse Y194 448924 DVnkSkEyFsKQK__ 1-cysPrx_C X +Src Src P05480 mouse RPT2 19179 P62192 Psmc1 mouse Y439 451910 EGtPEGLyL______ X +Src Src P05480 mouse Ack 10188 Q07912 TNK2 human Y860 448884 KVsstHyyLLPERPs X +Src Src P05480 mouse Ack 10188 Q07912 TNK2 human Y859 448883 KKVsstHyyLLPERP X +Src Src P05480 mouse CDH5 12562 P55284 Cdh5 mouse Y685 455658 MDARPAVyTQVQkPP X +Ephb2 EphB2 P54763 mouse EphB2 13844 P54763 Ephb2 mouse Y602 448327 IyIDPFtyEDPNEAV EphA2_TM X +Ephb2 EphB2 P54763 mouse EphB2 13844 P54763 Ephb2 mouse Y596 448326 MTPGMKIyIDPFtyE EphA2_TM X +PIK3CG PIK3CG P48736 human SET iso2 6418 Q01105-2 SET human S93 19009801 FVNHPQVsALLGEED NAP X X +PIK3CG PIK3CG P48736 human Src 6714 P12931 SRC human S39 23148310 FPAsQtPsKPAsAdG X +PIK3CG PIK3CG P48736 human SET iso2 6418 Q01105-2 SET human S9 6308300 sAPAAkVsKkELNsN X X +PIK3CG PIK3CG P48736 human Src 6714 P12931 SRC human S70 2192576 LFGGFNssDtVtsPQ X +PIK3CG PIK3CG P48736 human PIK3CG 5294 P48736 PIK3CG human S1101 449882 IKQGEKHsA______ X +TBK1 TBK1 Q9UHD2 human DRP1 74006 Q8K1M6 Dnm1l mouse S643 483971 VPVARKLsAREQRDC X 4867; 6319 +TBK1 TBK1 Q9UHD2 human STING 72512 Q3TBT3 Sting1 mouse S365 31064700 QEPRLLIsGMDQPLP X 62912; 72971; 51865 +TBK1 TBK1 Q9UHD2 human Nik 53859 Q9WUL6 Map3k14 mouse S349 27259008 ALQGSVSsGQAHsLA X +TBK1 TBK1 Q9UHD2 human Raptor 74370 Q8K4Q0 Rptor mouse S1189 23137513 VAGLGDGsIRVYDRR WD40 X +TBK1 TBK1 Q9UHD2 human PELI1 57162 Q96FA3 PELI1 human T80 7388010 DQHsIsYtLsRAQtV Pellino X +TBK1 TBK1 Q9UHD2 human SQSTM1 8878 Q13501 SQSTM1 human S403 22264800 ESLSQMLsMGFsDEG UBA_5 X X 39786 +TBK1 TBK1 Q9UHD2 human PRPS1 5631 P60891 PRPS1 human T228 34551795 DMADtCGtICHAADk Pribosyl_synth X X +TBK1 TBK1 Q9UHD2 human LMO7 iso3 4008 Q8WWI1-3 LMO7 human S417 4687531 KWKDRRKsYTSDLQK DUF4757 X +TBK1 TBK1 Q9UHD2 human optineurin 10133 Q96CV9 OPTN human S177 4762451 ssGssEDsFVEIRMA X X 31304; 57548 +TBK1 TBK1 Q9UHD2 human GABARAPL2 11345 P60520 GABARAPL2 human S88 1869546302 DKTVPQssLTMGQLY ATG8 X X +TBK1 TBK1 Q9UHD2 human DDAH2 23564 O95865 DDAH2 human S253 1872776108 QEALQKLsDVTLVPV X +TBK1 TBK1 Q9UHD2 human TNIP1 10318 Q15025 TNIP1 human S123 1880462802 PPSSGTssEFEVVTP X X +TBK1 TBK1 Q9UHD2 human TRIP12 9320 Q14669 TRIP12 human S312 452826 STKkRsEsPPAELPs X +TBK1 TBK1 Q9UHD2 human p70S6K 6198 P23443 RPS6KB1 human S447 448357 GsPRtPVsPVkFsPG X 9204 +TBK1 TBK1 Q9UHD2 human ASB8 140461 Q9H765 ASB8 human S17 1869062300 QSIQSKYsLSERLIR X +TBK1 TBK1 Q9UHD2 human optineurin 10133 Q96CV9 OPTN human S473 9511914 AQMEVYCsDFHAERA CC2-LZ X X +TBK1 TBK1 Q9UHD2 human SMCR8 140775 Q8TEV9 SMCR8 human T796 55469600 AsPAGAGtLHALSRY X +TBK1 TBK1 Q9UHD2 human GABARAPL2 11345 P60520 GABARAPL2 human S87 1869546303 VDKTVPQssLTMGQL ATG8 X X +TBK1 TBK1 Q9UHD2 human Nik 53859 Q9WUL6 Map3k14 mouse S354 23254681 VSsGQAHsLAsLAKT X +TBK1 TBK1 Q9UHD2 human STING 340061 Q86WV6 STING1 human S366 31064700 QEPELLIsGMEkPLP X X 30495; 39887; 85735; 50907; 19781; 41622; 43499; 40818; 99309; 72650 +TBK1 TBK1 Q9UHD2 human Nik 53859 Q9WUL6 Map3k14 mouse T690 27259007 TCHQTLPtPPRENPP X +TBK1 TBK1 Q9UHD2 human Tau iso8 4137 P10636-8 MAPT human S198 449551 sGDRsGyssPGsPGt X +TBK1 TBK1 Q9UHD2 human IRF3 3661 Q14653 IRF3 human T404 449031 NsHPLsLtsDQYKAY X X +TBK1 TBK1 Q9UHD2 human IRF3 3661 Q14653 IRF3 human S386 448684 ARVGGAssLENtVDL X X 37829; 73981; 96421; 91968 +TBK1 TBK1 Q9UHD2 human TRAF3IP2 103213 Q8N7N6 Traf3ip2 mouse S222 25687505 DLPGPLRsRELPPQF X X +TBK1 TBK1 Q9UHD2 human mTOR 56717 Q9JLN9 Mtor mouse S2159 20473601 RIQSIAPsLQVITSK X X +TBK1 TBK1 Q9UHD2 human LC3C 440738 Q9BXW4 MAP1LC3C human S96 1869546301 VNNKsLVsMSATMAE ATG8 X X +TBK1 TBK1 Q9UHD2 human DDAH2 23564 O95865 DDAH2 human T203 1872776102 VRAMAVLtDHPyASL X +TBK1 TBK1 Q9UHD2 human E2F1 1869 Q01094 E2F1 human S332 447868 TDSATIVsPPPSsPP X +TBK1 TBK1 Q9UHD2 human CXCR4 12767 P70658 Cxcr4 mouse S355 3193348 sTESEsssFHSs___ X +TBK1 TBK1 Q9UHD2 human PELI1 57162 Q96FA3 PELI1 human T288 7388016 QCPVGFNtLAFPsMk Pellino X +TBK1 TBK1 Q9UHD2 human Tau iso8 4137 P10636-8 MAPT human S214 447929 GsRsRtPsLPtPPtR X X 77348 +TBK1 TBK1 Q9UHD2 human Huntingtin 3064 P42858 HTT human S13 10206805 kLMkAFEsLksFQQQ X X +TBK1 TBK1 Q9UHD2 human IRF7 3665 Q92985 IRF7 human S477 1276101 VssLDSSsLsLCLsS X 12390 +TBK1 TBK1 Q9UHD2 human IRF3 3661 Q14653 IRF3 human S396 449028 NtVDLHIsNsHPLsL X X 4947; 29047; 83611; 10327; 53539; 81093; 52270; 61166 +TBK1 TBK1 Q9UHD2 human Nik 53859 Q9WUL6 Map3k14 mouse S752 27259006 PATAKGPsFPDRRAT X +TBK1 TBK1 Q9UHD2 human Tau iso8 4137 P10636-8 MAPT human S356 449104 rVQskIGsLDNItHV Tubulin-binding X X +TBK1 TBK1 Q9UHD2 human Tau iso8 4137 P10636-8 MAPT human S285 487455 INkkLDLsNVQskCG Tubulin-binding X X +TBK1 TBK1 Q9UHD2 human IRF7 3665 Q92985 IRF7 human S471 1276102 GTQREGVssLDSSsL X 5184 +TBK1 TBK1 Q9UHD2 human SIKE 80143 Q9BRV8 SIKE1 human S185 28076410 kELRELLsIssEsLQ SIKE X +TBK1 TBK1 Q9UHD2 human NRF1 18181 Q9WU00 Nrf1 mouse S318 1883500600 SNPDGTVsLIQVGTG X +TBK1 TBK1 Q9UHD2 human DDAH2 23564 O95865 DDAH2 human S245 1872776106 GGGDLPNsQEALQKL X +TBK1 TBK1 Q9UHD2 human Akt1 207 P31749 AKT1 human S473 447855 RPHFPQFsysAsGtA Pkinase_C X X 9271; 3787; 4060; 4051; 5102; 4058; 2336; 2337; 4075; 4070; 5012; 4071; 92982; 5315; 9563; 9018; 12694; 52240; 11962; 15116; 88106; 26580; 68035; 31957; 23430; 20235 +TBK1 TBK1 Q9UHD2 human TRIM56 81844 Q9BRZ2 TRIM56 human T442 4269997 LEEDRAQtPHEDGGP X +TBK1 TBK1 Q9UHD2 human STAT6 6778 P42226 STAT6 human S407 21561700 PIQLQALsLPLVVIV STAT_bind X X +TBK1 TBK1 Q9UHD2 human PRPS2 5634 P11908 PRPS2 human T228 1874512700 DMADtCGtICHAADk Pribosyl_synth X X +TBK1 TBK1 Q9UHD2 human STX17 55014 P56962 STX17 human S202 102898200 SQQEKIDsIADHVNS SNARE X 28630 +TBK1 TBK1 Q9UHD2 human mTOR 2475 P42345 MTOR human S2159 20473601 RIQsIAPsLQVItSk X X +TBK1 TBK1 Q9UHD2 human Tau iso8 4137 P10636-8 MAPT human T30 1873559802 RKDQGGytMHQDQEG X X +TBK1 TBK1 Q9UHD2 human TBK1 29110 Q9UHD2 TBK1 human S172 447732 EDDEQFVsLyGTEEy Pkinase X X 5483; 13498; 14590; 14586; 54382; 70483; 20399 +TBK1 TBK1 Q9UHD2 human IRF7 3665 Q92985 IRF7 human S472 1276103 TQREGVssLDSSsLs X 5184 +TBK1 TBK1 Q9UHD2 human Raptor 57521 Q8N122 RPTOR human S877 3205938 HIHQAGGsPPAssts X X +TBK1 TBK1 Q9UHD2 human SMCR8 140775 Q8TEV9 SMCR8 human S402 55469601 QDRPPsSsLEECPIP X +TBK1 TBK1 Q9UHD2 human SIKE 80143 Q9BRV8 SIKE1 human S198 28076406 LQARkENsMDTASQA X +TBK1 TBK1 Q9UHD2 human p70S6K 6198 P23443 RPS6KB1 human T444 448358 RFIGsPRtPVsPVkF X 9204 +TBK1 TBK1 Q9UHD2 human Nik 53859 Q9WUL6 Map3k14 mouse S862 27259003 GVKVQIQsLNGEHLH X +TBK1 TBK1 Q9UHD2 human IRF3 3661 Q14653 IRF3 human S398 449029 VDLHIsNsHPLsLts X X +TBK1 TBK1 Q9UHD2 human IRF5 3663 Q13568 IRF5 human S293 27101101 VELFGPIsLEQVRFP IRF-3 X X +TBK1 TBK1 Q9UHD2 human Tau iso8 4137 P10636-8 MAPT human S324 449328 kVtskCGsLGNIHHk Tubulin-binding X X +TBK1 TBK1 Q9UHD2 human Nik 53859 Q9WUL6 Map3k14 mouse S357 27259012 GQAHsLAsLAKTWSS X +TBK1 TBK1 Q9UHD2 human Tau iso8 4137 P10636-8 MAPT human S289 487456 LDLsNVQskCGsKDN Tubulin-binding X X +TBK1 TBK1 Q9UHD2 human HDAC3 8841 O15379 HDAC3 human S424 455624 DHDNDKEsDVEI___ X 3815 +TBK1 TBK1 Q9UHD2 human Nik 53859 Q9WUL6 Map3k14 mouse S728 27259004 KAPALNLsKEESGTW X +TBK1 TBK1 Q9UHD2 human PELI1 57162 Q96FA3 PELI1 human S293 7388014 FNtLAFPsMkRkDVV Pellino X +TBK1 TBK1 Q9UHD2 human SIKE 80143 Q9BRV8 SIKE1 human S188 28076408 RELLsIssEsLQARk X +TBK1 TBK1 Q9UHD2 human Nik 53859 Q9WUL6 Map3k14 mouse S821 27259011 SsRDTLssGVHSWNS X +TBK1 TBK1 Q9UHD2 human XIAP 331 P98170 XIAP human S430 22547400 QDESSQtsLQkEIst X X +TBK1 TBK1 Q9UHD2 human NRF1 18181 Q9WU00 Nrf1 mouse S384 1883500602 EATQAVAsLAEAAVA X +TBK1 TBK1 Q9UHD2 human TICAM1 148022 Q8IUC6 TICAM1 human S210 31858079 LAsNLEIsQsPTMPF X +TBK1 TBK1 Q9UHD2 human Akt1 11651 P31750 Akt1 mouse S473 447855 RPHFPQFsysAsGtA Pkinase_C X 9271; 3787; 4060; 4051; 5102; 4058; 2336; 2337; 4075; 4070; 5012; 4071; 92982; 5315; 9563; 9018; 12694; 52240; 11962; 15116; 88106; 26580; 68035; 31957; 23430; 20235 +TBK1 TBK1 Q9UHD2 human SIKE 80143 Q9BRV8 SIKE1 human S133 28076407 PVLkAHQsHSAEIES SIKE X +TBK1 TBK1 Q9UHD2 human PBXIP1 57326 Q96AQ6 PBXIP1 human S147 471206 REEGRCsssDDDtDV X X +TBK1 TBK1 Q9UHD2 human NFkB-p65 5970 Q04206 RELA human S536 447800 sGDEDFSsIADMDFS X X 4887; 3036; 3031; 4886; 3033; 4025; 5733; 13346; 76778; 31553; 80477; 73992; 87672; 83962 +TBK1 TBK1 Q9UHD2 human METTL3 56339 Q86U44 METTL3 human S67 1876371800 GPKPSTAsAVPELAT X X +TBK1 TBK1 Q9UHD2 human CTNNB1 1499 P35222 CTNNB1 human S552 472273 QDtQRRtsMGGtQQQ X 9566; 5651 +TBK1 TBK1 Q9UHD2 human Nik 53859 Q9WUL6 Map3k14 mouse S89 27259005 AQAECENsQEFSPTF X +TBK1 TBK1 Q9UHD2 human MAVS 57506 Q7Z434 MAVS human S442 58984003 CFEDLAIsASTSLGM X X +TBK1 TBK1 Q9UHD2 human MCPIP1 230738 Q5D1E7 Zc3h12a mouse S513 34505699 YPSREYWsEPYPLPP X +TBK1 TBK1 Q9UHD2 human Nik 53859 Q9WUL6 Map3k14 mouse S113 27259010 QQYSQSEsLDQIPNN X +TBK1 TBK1 Q9UHD2 human Nik 53859 Q9WUL6 Map3k14 mouse S820 27259002 QSsRDTLssGVHSWN X +TBK1 TBK1 Q9UHD2 human Raptor 74370 Q8K4Q0 Rptor mouse S877 3205938 HMHQVGGsPPASsts X X +TBK1 TBK1 Q9UHD2 human Tau iso8 4137 P10636-8 MAPT human S191 487448 ssGEPPKsGDRsGys X +TBK1 TBK1 Q9UHD2 human IRF7 3665 Q92985 IRF7 human S479 2868600 sLDSSsLsLCLsSAN X +TBK1 TBK1 Q9UHD2 human STAT3 20848 P42227 Stat3 mouse S754 35494901 SAGGQFEsLTFDMDL X X 98543 +TBK1 TBK1 Q9UHD2 human NFkB-p65 19697 Q04207 Rela mouse S534 447800 sGDEDFssIADMDFS X 4887; 3036; 3031; 4886; 3033; 4025; 5733; 13346; 76778; 31553; 80477; 73992; 87672; 83962 +TBK1 TBK1 Q9UHD2 human PELI1 57162 Q96FA3 PELI1 human S76 7388015 IsNKDQHsIsYtLsR Pellino X +TBK1 TBK1 Q9UHD2 human Huntingtin 3064 P42858 HTT human S16 12056100 kAFEsLksFQQQQQQ X X +TBK1 TBK1 Q9UHD2 human IRF3 3661 Q14653 IRF3 human S402 449030 IsNsHPLsLtsDQYK X X +TBK1 TBK1 Q9UHD2 human optineurin 10133 Q96CV9 OPTN human S513 21214714 FEDGGRQsLMEMQsR X X +TBK1 TBK1 Q9UHD2 human INSR 24954 P15127 Insr rat S1034 454090 LRELGQGsFGMVYEG PK_Tyr_Ser-Thr X +TBK1 TBK1 Q9UHD2 human LC3C 440738 Q9BXW4 MAP1LC3C human S93 1869546300 YLLVNNKsLVsMSAT ATG8 X X +TBK1 TBK1 Q9UHD2 human IRF3 3661 Q14653 IRF3 human S385 448696 MARVGGAssLENtVD X +TBK1 TBK1 Q9UHD2 human RKIP 5037 P30086 PEBP1 human S109 59070500 VLsDyVGsGPPkGTG PBP X X +TBK1 TBK1 Q9UHD2 human IRF3 3661 Q14653 IRF3 human S175 14567912 PQPLRsPsLDNPtPF X +TBK1 TBK1 Q9UHD2 human STAT2 6773 P52630 STAT2 human T404 1869973803 IWDFGYLtLVEQRSG STAT_bind X +TBK1 TBK1 Q9UHD2 human Akt1 11651 P31750 Akt1 mouse T308 447856 KDGAtMKtFCGtPEy Pkinase X 5106; 2965; 9275; 4056; 5056; 13842; 13038; 43506; 48646; 86758; 80722; 77440; 80556 +TBK1 TBK1 Q9UHD2 human TRAF3IP2 103213 Q8N7N6 Traf3ip2 mouse S209 25687506 ERPLPLTsSCYLQDL X X +TBK1 TBK1 Q9UHD2 human MCPIP1 230738 Q5D1E7 Zc3h12a mouse S494 56659543 AMGAGHFsVPTDYVP X +TBK1 TBK1 Q9UHD2 human ER-alpha 2099 P03372 ESR1 human S305 448805 IkRSkkNsLALSLtA X +TBK1 TBK1 Q9UHD2 human STING 340061 Q86WV6 STING1 human S358 13201900 VPStstMsQEPELLI X +TBK1 TBK1 Q9UHD2 human optineurin 71648 Q8K3K8 Optn mouse S187 4762451 SGGSsEDsFVEIRMT X 31304 +TBK1 TBK1 Q9UHD2 human IRF3 3661 Q14653 IRF3 human S173 6370303 PCPQPLRsPsLDNPt X +TBK1 TBK1 Q9UHD2 human Nik 53859 Q9WUL6 Map3k14 mouse S48 27259009 KLEAVEKsPVFCGKW X +TBK1 TBK1 Q9UHD2 human TNIP1 10318 Q15025 TNIP1 human S122 1880462800 KPPSSGTssEFEVVT X X +TBK1 TBK1 Q9UHD2 human TRAF3IP2 103213 Q8N7N6 Traf3ip2 mouse S147 25687507 ESDKSDPsLPNALAD X X +TBK1 TBK1 Q9UHD2 human SIKE 80143 Q9BRV8 SIKE1 human S187 28076409 LRELLsIssEsLQAR SIKE X +TBK1 TBK1 Q9UHD2 human SQSTM1 8878 Q13501 SQSTM1 human S366 476290 PEsEGPssLDPsQEG X X 26317 +TBK1 TBK1 Q9UHD2 human SIKE 80143 Q9BRV8 SIKE1 human S190 28076405 LLsIssEsLQARkEN X +TBK1 TBK1 Q9UHD2 human IRF5 3663 Q13568 IRF5 human S158 27101102 QRMLPSLsLTEDVKW X X +TBK1 TBK1 Q9UHD2 human Tau iso8 4137 P10636-8 MAPT human S305 487457 kHVPGGGsVQIVykP Tubulin-binding X X +TBK1 TBK1 Q9UHD2 human IRF3 3661 Q14653 IRF3 human S405 449032 sHPLsLtsDQYKAYL X X +TBK1 TBK1 Q9UHD2 human Nik 53859 Q9WUL6 Map3k14 mouse S153 27259001 RRKKRSKsLAQAGVA X +TBK1 TBK1 Q9UHD2 human Akt1 207 P31749 AKT1 human T308 447856 kDGAtMKtFCGtPEy Pkinase X X 5106; 2965; 9275; 4056; 5056; 13842; 13038; 43506; 48646; 86758; 80722; 77440; 80556 +TBK1 TBK1 Q9UHD2 human DDAH2 23564 O95865 DDAH2 human T211 1872776104 DHPyASLtLPDDAAA X +Hipk3 HIPK3 Q9ERH7 mouse AML3 iso5 12393 Q08775-5 Runx2 mouse T326 14694701 sPSIHSTtPLSSTRG X X +Hipk3 HIPK3 Q9ERH7 mouse AML3 iso5 12393 Q08775-5 Runx2 mouse S319 10892802 SYLSQMTsPSIHSTt X X +TEK TIE2 Q02763 human TIE2 7010 Q02763 TEK human Y992 448373 LSRGQEVyVKKtMGR PK_Tyr_Ser-Thr X 4221 +TEK TIE2 Q02763 human TIE2 7010 Q02763 TEK human Y1108 448372 TyVNTTLyEKFTyAG X +Rps6ka3 RSK2 NP_001178933 rat BSN 29138 O88778 Bsn rat S2845 456576 KTLQRSLsDPKPLSP X +Rps6ka3 RSK2 NP_001178933 rat nNOS 24598 P29476 Nos1 rat S847 447886 SYKVRFNsVSSYSDS Flavodoxin_1 X X +Rps6ka3 RSK2 NP_001178933 rat PLD1 25096 P70496 Pld1 rat T147 448573 PIPTKRHtFRRQNVK PX X 3831 +Rps6ka3 RSK2 NP_001178933 rat MEF2A 309957 Q2MJT0 Mef2a rat S192 7533201 ATLHRNVsPGAPQRP X X +Rps6ka3 RSK2 NP_001178933 rat BSN 12217 O88737 Bsn mouse S2860 456576 KTLQRsLsDPKPLsP X +Rps6ka3 RSK2 NP_001178933 rat Fos 2353 P01100 FOS human S362 448481 AAAHRKGssSNEPSS X +PRKD3 PRKD3 O94806 human HDAC5 10014 Q9UQL6 HDAC5 human S498 447996 RPLSRtQsSPLPQsP X 3424 +PRKD3 PRKD3 O94806 human PRKD1 5587 Q15139 PRKD1 human S738 448589 ARIIGEksFRRsVVG Pkinase X 2054 +PRKD3 PRKD3 O94806 human Cortactin 2017 Q14247 CTTN human S298 5014901 EKLAkHEsQQDyskG HS1_rep X +PRKD3 PRKD3 O94806 human GIT1 28964 Q9Y2X7 GIT1 human S46 25784901 RSLGRHIsIVkHLRH ArfGap X X +PRKD3 PRKD3 O94806 human PRKD1 5587 Q15139 PRKD1 human S742 448590 GEksFRRsVVGtPAy Pkinase X +PRKD3 PRKD3 O94806 human MFF 56947 Q9GZY8 MFF human S172 484865 GQLVRNDsLWHRsDs Miff X +CSF1R CSFR P07333 human CSFR 1436 P07333 CSF1R human Y809 448365 DIMNDSNyIVkGNAR PK_Tyr_Ser-Thr X X 3154 +CSF1R CSFR P07333 human CSFR 1436 P07333 CSF1R human Y561 450118 EsyEGNsytFIDPtQ X +CSF1R CSFR P07333 human CSFR 1436 P07333 CSF1R human Y699 451527 DPEGGVDyKNIHLEK PK_Tyr_Ser-Thr X 3399; 12251 +CSF1R CSFR P07333 human CSFR 1436 P07333 CSF1R human Y546 2866400 KYKQKPKyQVRWKII X 3083 +PRKCB PKCB iso2 P05771-2 human Tau iso8 4137 P10636-8 MAPT human S352 487459 DFKDrVQskIGsLDN Tubulin-binding X +PRKCB PKCB iso2 P05771-2 human ITGB2 3689 P05107 ITGB2 human S745 448532 FEkEKLksQWNNDNP Integrin_b_cyt X +PRKCB PKCB iso2 P05771-2 human TRPV1 7442 Q8NER1 TRPV1 human T705 487542 WKLQRAItILDTEKS X +PRKCB PKCB iso2 P05771-2 human DAB2 1601 P98082 DAB2 human S24 451211 QAAPKAPsKKEKKKG X +PRKCB PKCB iso2 P05771-2 human PKCB iso2 5579 P05771-2 PRKCB human S660 1869073011 QsEFEGFsFVNsEFL Pkinase_C X X 9371 +PRKCB PKCB iso2 P05771-2 human CACNA1B 257648 Q02294 Cacna1b rat S1757 465548 FEMLKHMsPPLGLGK GPHH X +PRKCB PKCB iso2 P05771-2 human Tau iso8 4137 P10636-8 MAPT human S258 487453 PDLkNVKskIGstEN Tubulin-binding X +PRKCB PKCB iso2 P05771-2 human PPAR-alpha 5465 Q07869 PPARA human S230 2902207 VKARVILsGKASNNP X +PRKCB PKCB iso2 P05771-2 human CACNA1C 100101555 P15381 CACB rabbit S1928 455278 ASLGRRAsFHLECLK CAC1F_C X +PRKCB PKCB iso2 P05771-2 human CACNA1B 257648 Q02294 Cacna1b rat S2108 465549 RKQERGRsQERRQPS X +PRKCB PKCB iso2 P05771-2 human ATF-2 1386 P15336 ATF2 human S121 6406001 LAtPIIRsKIEEPSV X +PRKCB PKCB iso2 P05771-2 human KIR3DL1 3811 P43629 KIR3DL1 human S415 990302 QRKITRPsQRPKtPP X +PRKCB PKCB iso2 P05771-2 human EIF6 3692 P56537 EIF6 human S235 450271 QPstIAtsMRDsLID X +PRKCB PKCB iso2 P05771-2 human SHP-2 5781 Q06124 PTPN11 human S591 469623 GLMQQQksFR_____ X +PRKCB PKCB iso2 P05771-2 human GSK3B 2932 P49841 GSK3B human S9 449111 SGRPRttsFAEsCkP X 9336; 9331; 9327; 9323; 9322; 9325; 5558; 8566; 79774; 8466; 25462; 14026; 14332; 14310; 14630 +PRKCB PKCB iso2 P05771-2 human MYH9 4627 P35579 MYH9 human S1916 451181 AMNREVssLkNkLRr Myosin_tail_1 X +PRKCB PKCB iso2 P05771-2 human CKM 24265 P00564 Ckm rat S128 5410301 LDPNyVLssRVRTGR X +PRKCB PKCB iso2 P05771-2 human CACNA1B 257648 Q02294 Cacna1b rat S2132 465550 YsCDRFGsREPPQPK X +PRKCB PKCB iso2 P05771-2 human P70S6KB 6199 Q9UBS0 RPS6KB2 human S473 450071 PPSGTKKsKRGRGRP X +PRKCB PKCB iso2 P05771-2 human ITGB2 3689 P05107 ITGB2 human T758 448533 NPLFksAtttVMNPk Integrin_b_cyt X +PRKCB PKCB iso2 P05771-2 human JNK2 26420 Q9WTU6 Mapk9 mouse S129 456485 ELDHERMsYLLYQML Pkinase X +PRKCB PKCB iso2 P05771-2 human TRPV6 55503 Q9H1D0 TRPV6 human S184 12173901 LARRAsVsARAtGTA Ank_2 X +PRKCB PKCB iso2 P05771-2 human C5aR 728 P21730 C5AR1 human S334 448819 sVVREsKsFTRsTVD X X +PRKCB PKCB iso2 P05771-2 human p47phox 653361 P14598 NCF1 human S320 451726 QRsRKRLsQDAYRRN NECFESHC X +PRKCB PKCB iso2 P05771-2 human MFN1 55669 Q8IWA4 MFN1 human S284 1871247400 QNRIFFVsAkEVLsA X +PRKCB PKCB iso2 P05771-2 human MOR-1 18390 P42866 Oprm1 mouse S363 447783 STIEQQNsARIRQNt X +PRKCB PKCB iso2 P05771-2 human eIF3-theta 8661 Q14152 EIF3A human S1364 487404 RAEKDREsLRRtKNE X +PRKCB PKCB iso2 P05771-2 human Lamin B1 4001 P20700 LMNB1 human S405 448733 VtVsRAsssRsVRtt X X +PRKCB PKCB iso2 P05771-2 human CACNA1C 100101555 P15381 CACB rabbit S528 486358 ARLAHRIsKSKFsRY X +PRKCB PKCB iso2 P05771-2 human SYT6 148281 Q5T7P8 SYT6 human T418 456499 RLKKKKttIKKNTLN C2 X +PRKCB PKCB iso2 P05771-2 human MCU 90550 Q8NE86 MCU human S92 27259017 VISVRLPsRRERCQF X +PRKCB PKCB iso2 P05771-2 human eIF4G iso8 1981 Q04637-8 EIF4G1 human S1093 3194291 FAPGGRLsWGKGSSG X +PRKCB PKCB iso2 P05771-2 human AID 11628 Q9WVE0 Aicda mouse S3 20660600 _____MDsLLMKQKK X +PRKCB PKCB iso2 P05771-2 human CACNA1C 100101555 P15381 CACB rabbit S533 453091 RIsKSKFsRYWRRWN X +PRKCB PKCB iso2 P05771-2 human MFN1 55669 Q8IWA4 MFN1 human S290 1871247401 VsAkEVLsARKQKAQ X +PRKCB PKCB iso2 P05771-2 human SHP-2 5781 Q06124 PTPN11 human S576 469622 CAEMREDsARVyENV X +PRKCB PKCB iso2 P05771-2 human p47phox 653361 P14598 NCF1 human S315 451725 AHsIHQRsRKRLsQD NECFESHC X +PRKCB PKCB iso2 P05771-2 human TRPV6 55503 Q9H1D0 TRPV6 human T728 12173902 MPSVSRstSRssANW X +PRKCB PKCB iso2 P05771-2 human RAB11A 8766 P62491 RAB11A human S177 22826101 TEIYRIVsQkQMSDR X +PRKCB PKCB iso2 P05771-2 human MFN1 192647 Q8R4Z9 Mfn1 rat S86 1498941800 AFFGRTSsGKSSVIN Dynamin_N X X +PRKCB PKCB iso2 P05771-2 human PPAR-alpha 5465 Q07869 PPARA human S179 457549 RFGRMPRsEKAKLkA X +PRKCB PKCB iso2 P05771-2 human TNNI3 29248 P23693 Tnni3 rat S23 448423 PAPVRRRssANYRAY Troponin-I_N X 4004 +PRKCB PKCB iso2 P05771-2 human p47phox 653361 P14598 NCF1 human S328 449404 QDAYRRNsVRFLQQR NECFESHC X +PRKCB PKCB iso2 P05771-2 human Tau iso8 4137 P10636-8 MAPT human S324 449328 kVtskCGsLGNIHHk Tubulin-binding X +PRKCB PKCB iso2 P05771-2 human p73 7161 O15350 TP73 human S388 6417400 VPQPLVDsYRQQQQL X +PRKCB PKCB iso2 P05771-2 human CHAT iso3 1103 P28329-3 CHAT human S476 454037 HKAAVPAsEKLLLLK Carn_acyltransf X +PRKCB PKCB iso2 P05771-2 human CACNA1B 257648 Q02294 Cacna1b rat S425 465547 KRAAtKKsRNDLIHA X +PRKCB PKCB iso2 P05771-2 human Lamin B1 4001 P20700 LMNB1 human S395 448732 LkLsPsPssRVtVsR X X +PRKCB PKCB iso2 P05771-2 human TNNI3 29248 P23693 Tnni3 rat S24 448424 APVRRRssANYRAYA Troponin-I_N X 4004 +PRKCB PKCB iso2 P05771-2 human CACNA1D 29716 P27732 Cacna1d rat S81 470135 PPPVGSLsQRKRQQY X +PRKCB PKCB iso2 P05771-2 human CHAT iso3 1103 P28329-3 CHAT human S346 454035 LLKHVTQssRKLIRA Carn_acyltransf X +PRKCB PKCB iso2 P05771-2 human CHAT iso3 1103 P28329-3 CHAT human S440 449057 VPTYESAsIRRFQEG Carn_acyltransf X +PRKCB PKCB iso2 P05771-2 human hnRNP P2 2521 P35637 FUS human S257 450486 GrGGMGGsDrGGFNk X +PRKCB PKCB iso2 P05771-2 human CACNA1B 257648 Q02294 Cacna1b rat T422 465546 AVLKRAAtKKsRNDL X +PRKCB PKCB iso2 P05771-2 human SYT6 148281 Q5T7P8 SYT6 human T417 456500 RRLKKKKttIKKNTL C2 X +PRKCB PKCB iso2 P05771-2 human CHAT iso3 1103 P28329-3 CHAT human S347 454036 LKHVTQssRKLIRAD Carn_acyltransf X +PRKCB PKCB iso2 P05771-2 human CHAT iso3 1103 P28329-3 CHAT human T255 454038 TVLVKDStNRDSLDM Carn_acyltransf X +PRKCB PKCB iso2 P05771-2 human p47phox 653361 P14598 NCF1 human S370 451730 PAVPPRPsADLILNR p47_phox_C X +PRKCB PKCB iso2 P05771-2 human MYH9 25745 Q62812 Myh9 rat S1917 451181 AMNREVSsLKNKLRR Myosin_tail_1 X X +PRKCB PKCB iso2 P05771-2 human p47phox 653361 P14598 NCF1 human S303 449405 RGAPPRRssIRNAHs NECFESHC X +PRKCB PKCB iso2 P05771-2 human mGluR5 24418 P31424 Grm5 rat S839 455778 VRSAFTTstVVRMHV X +PRKCB PKCB iso2 P05771-2 human ghrelin 51738 Q9UBU3 GHRL human S41 2235100 RVQQRKEsKKPPAKL Motilin_ghrelin X +PRKCB PKCB iso2 P05771-2 human Tau iso8 4137 P10636-8 MAPT human S293 449327 NVQskCGsKDNIkHV Tubulin-binding X +PRKCB PKCB iso2 P05771-2 human CACNA1C 100101555 P15381 CACB rabbit S1674 480102 QGLVGKPsQRNALSL X +PRKCB PKCB iso2 P05771-2 human MFN1 67414 Q811U4 Mfn1 mouse S86 1498941800 AFFGRTSsGKSSVIN Dynamin_N X X +PRKCB PKCB iso2 P05771-2 human KCNE1 3753 P15382 KCNE1 human S102 10349700 VQARVLEsYRSCYVV ISK_Channel X +PRKCB PKCB iso2 P05771-2 human p47phox 653361 P14598 NCF1 human S359 451729 EERQtQRsKPQPAVP p47_phox_C X +PRKCB PKCB iso2 P05771-2 human p47phox 653361 P14598 NCF1 human S304 449406 GAPPRRssIRNAHsI NECFESHC X +PRKCB PKCB iso2 P05771-2 human MFN1 55669 Q8IWA4 MFN1 human S86 1498941800 AFFGRTSsGKSSVIN Dynamin_N X X +PRKCB PKCB iso2 P05771-2 human GSK3A 2931 P49840 GSK3A human S21 448584 sGrARtssFAEPGGG X 9337; 9316; 9331; 5090; 9327; 8452; 8566 +PRKCB PKCB iso2 P05771-2 human p47phox 653361 P14598 NCF1 human S379 451498 DLILNRCsEstKRKL p47_phox_C X +PRKCB PKCB iso2 P05771-2 human SYT6 148281 Q5T7P8 SYT6 human T283 456501 DRKCKLQtRVHRKTL C2 X +Cdk8 CDK8 Q8R3L8 mouse STAT3 20848 P42227 Stat3 mouse Y705 448192 DPGsAAPyLktkFIC X 4093; 9145; 4324; 9131; 9138; 4323; 4074; 4113; 48313; 20977; 25023; 8119; 52075; 52527; 73533; 61958; 73452; 16185; 74309 +Cdk8 CDK8 Q8R3L8 mouse OSBPL3 iso3 71720 D3Z194 Osbpl3 mouse S302 3212430 SGPVRLHssNPNLST X +Cdk8 CDK8 Q8R3L8 mouse OSBPL3 iso3 71720 D3Z194 Osbpl3 mouse S303 3212433 GPVRLHssNPNLSTL X +Cdk8 CDK8 Q8R3L8 mouse OSBPL3 iso3 71720 D3Z194 Osbpl3 mouse S250 3212427 DVLHRtYsAPAINAI X +Cdk8 CDK8 Q8R3L8 mouse OSBPL3 iso3 71720 D3Z194 Osbpl3 mouse T248 6209017 SMDVLHRtYsAPAIN X +Cdk8 CDK8 Q8R3L8 mouse STAT1 20846 P42225 Stat1 mouse S727 447753 tDNLLPMsPEEFDEM STAT1_TAZ2bind X 9177; 8826; 62390 +Cdk8 CDK8 Q8R3L8 mouse STAT5A 20850 P42230 Stat5a mouse S725 448749 TYMDQAPsPVVCPQP X +SYK Syk P43405 human STAT3 20848 P42227 Stat3 mouse Y705 448192 DPGsAAPyLktkFIC X 4093; 9145; 4324; 9131; 9138; 4323; 4074; 4113; 48313; 20977; 25023; 8119; 52075; 52527; 73533; 61958; 73452; 16185; 74309 +SYK Syk P43405 human Syk 20963 P48025 Syk mouse Y317 447658 STVSFNPyEPtGGPW X 2715 +SYK Syk P43405 human SLC4A1 6521 P02730 SLC4A1 human Y904 455304 EEEGRDEyDEVAMPV X +SYK Syk P43405 human PKM 18746 P52480 Pkm mouse Y105 450528 FAsDPILyRPVAVAL PK X 3827 +SYK Syk P43405 human GCET2 257144 Q8N6F7 GCSAM human Y106 463673 sGNsAEEyyENVPCk HGAL X +SYK Syk P43405 human SHC1 iso2 6464 P29353-2 SHC1 human Y317 448511 ELFDDPSyVNVQNLD X +SYK Syk P43405 human FCGR2C 9103 P31995 FCGR2C human Y310 449501 tDDDKNIyLTLPPND X +SYK Syk P43405 human DBNL 13169 Q62418 Dbnl mouse Y340 450090 QTEEEPTyEVPPEQD X +SYK Syk P43405 human PRDX2 7001 P32119 PRDX2 human Y193 448985 NVDDskEyFskHN__ 1-cysPrx_C X X +SYK Syk P43405 human SLC4A1 6521 P02730 SLC4A1 human Y21 457533 ENLEQEEyEDPDIPE X X +SYK Syk P43405 human LAX1 54900 Q8IWV1 LAX1 human Y268 35546002 SSQISNDyVNMTGLD LAX X +SYK Syk P43405 human SLC4A1 6521 P02730 SLC4A1 human Y8 451570 MEELQDDyEDMMEEN X X +SYK Syk P43405 human PLCG1 5335 P19174 PLCG1 human Y771 448575 IGtAEPdyGALyEGR X +SYK Syk P43405 human BLNK 29760 Q8WV28 BLNK human Y96 447719 EENADDSyEPPPVEQ X X 3601 +SYK Syk P43405 human PLCG2 5336 P16885 PLCG2 human Y759 447941 LyDVsRMyVDPsEIN X 3874; 50535 +SYK Syk P43405 human HS1 3059 P14317 HCLS1 human Y378 451635 EPEPENDyEDVEEMD X X +SYK Syk P43405 human SHC1 iso2 6464 P29353-2 SHC1 human Y239 448509 EEPPDHQyyNDFPGK X X +SYK Syk P43405 human FCGR2A 2212 P12318 FCGR2A human Y304 449552 tDDDKNIyLTLPPND X +SYK Syk P43405 human Ikaros 10320 Q13422 IKZF1 human S361 14160239 LAEGtPRsNHsAQDs X +SYK Syk P43405 human CFTR 1080 P13569 CFTR human Y512 21041602 NIIFGVsyDEyRYRS ABC_tran X X +SYK Syk P43405 human LAB 7462 Q9GZY6 LAT2 human Y233 450646 EEDGEPDyVNGEVAA LAT2 X +SYK Syk P43405 human Ikaros 10320 Q13422 IKZF1 human S364 4714822 GtPRsNHsAQDsAVE X +SYK Syk P43405 human Syk 25155 Q64725 Syk rat Y520 447662 LRADENyyKAQTHGK PK_Tyr_Ser-Thr X 2710; 12967; 5514; 4349; 6485; 12081; 46994; 16859 +SYK Syk P43405 human DEPTOR 64798 Q8TB45 DEPTOR human Y289 1875073002 ssCGssGyFsssPtL X +SYK Syk P43405 human Cortactin 2017 Q14247 CTTN human Y421 447702 rLPssPVyEDAAsFK X 4569 +SYK Syk P43405 human TLR2 24088 Q9QUN7 Tlr2 mouse Y647 1876860404 CYDAFVSySEQDSHW TIR X +SYK Syk P43405 human RhoGDI beta 397 P52566 ARHGDIB human Y24 448978 ELdskLNykPPPQks Rho_GDI X +SYK Syk P43405 human BLNK 29760 Q8WV28 BLNK human Y84 449841 EHSDSEMyVMPAEEN X X 65060; 26528 +SYK Syk P43405 human PLCG1 5335 P19174 PLCG1 human Y783 447667 EGRNPGFyVEANPMP X 2821; 14461; 14008; 25678; 88717 +SYK Syk P43405 human STAT5A 6776 P42229 STAT5A human Y694 447767 LAkAVDGyVkPQIkQ X 9365; 9356; 9359; 9351; 4322; 9314; 3939; 40284; 5387; 14603; 66740; 51879; 72712 +SYK Syk P43405 human LAB 7462 Q9GZY6 LAT2 human Y193 450645 EDEEsEDyQNsAsIH LAT2 X +SYK Syk P43405 human CBL 867 P22681 CBL human Y700 448529 EGEEDtEyMtPssRP X 8869 +SYK Syk P43405 human PKACA 18747 P05132 Prkaca mouse Y331 15230353 DTSNFDDyEEEEIRV X X +SYK Syk P43405 human FCGR2C 9103 P31995 FCGR2C human Y287 449556 PEETNNDyETADGGy X +SYK Syk P43405 human GCET2 257144 Q8N6F7 GCSAM human Y86 449473 tysEELCytLINHRV HGAL X +SYK Syk P43405 human SLC4A1 6521 P02730 SLC4A1 human Y359 455384 AKPDssFyKGLDLNG X +SYK Syk P43405 human SNCA 6622 P37840 SNCA human Y133 448280 EMPsEEGyQDyEPEA X X +SYK Syk P43405 human RIP140 268903 Q8CBD1 Nrip1 mouse Y418 25234800 TPTTIDEySDNNPSF NRIP1_repr_2 X X +SYK Syk P43405 human SHC1 iso2 6464 P29353-2 SHC1 human Y240 448510 EPPDHQyyNDFPGKE X X +SYK Syk P43405 human LAB 7462 Q9GZY6 LAT2 human Y136 450963 EDDDANsyENVLICK LAT2 X +SYK Syk P43405 human Ig-alpha 12518 P11911 Cd79a mouse S197 21127303 CsMyEDIsRGLQGty ITAM X X +SYK Syk P43405 human SNCA 6622 P37840 SNCA human Y136 448281 sEEGyQDyEPEA___ X X +SYK Syk P43405 human PYCARD 66824 Q9EPB4 Pycard mouse Y144 465096 SVLTEGQyQAVRAET CARD X X +SYK Syk P43405 human RIP140 268903 Q8CBD1 Nrip1 mouse Y364 25234802 SsPKNTSyKNSLERN X X +SYK Syk P43405 human DUSP3 1845 P51452 DUSP3 human Y138 448718 SPTLVIAyLMMRQKM DSPc X X +SYK Syk P43405 human Syk 6850 P43405 SYK human Y352 447660 tEVyEsPyADPEEIR X 2701; 2717; 14791; 73382; 82975; 31754 +SYK Syk P43405 human SNCA 6622 P37840 SNCA human Y125 448279 VDPDNEAyEMPsEEG Synuclein X X +SYK Syk P43405 human DOCK2 1794 Q92608 DOCK2 human Y224 1876205006 SsPTHsLyVFVRNFV DOCK_N X +SYK Syk P43405 human BLNK 29760 Q8WV28 BLNK human Y178 447716 LLEDEADyVVPVEDN X X +SYK Syk P43405 human Syk 20963 P48025 Syk mouse Y342 447659 LPMDTEVyESPyADP X +SYK Syk P43405 human FCGR2A 2212 P12318 FCGR2A human Y281 449554 LEEtNNDyEtADGGy X +SYK Syk P43405 human DOCK2 1794 Q92608 DOCK2 human Y122 1876205004 LQVQSMMyDLMEWRS DOCK_N X +SYK Syk P43405 human DOCK2 1794 Q92608 DOCK2 human Y985 1876205000 DLIGKNVyPGDWMAM X +SYK Syk P43405 human Btk 695 Q06187 BTK human Y551 447486 RYVLDDEytsSVGSk PK_Tyr_Ser-Thr X 69360; 18805; 64137; 16803 +SYK Syk P43405 human LAX1 54900 Q8IWV1 LAX1 human Y294 35546001 AFQCCRDyENVPAAD LAX X +SYK Syk P43405 human GCET2 257144 Q8N6F7 GCSAM human Y128 463674 LGGTEtEySLLHMPS HGAL X X +SYK Syk P43405 human Syk 6850 P43405 SYK human Y348 447659 LPMDtEVyEsPyADP X +SYK Syk P43405 human RIP140 268903 Q8CBD1 Nrip1 mouse Y436 25234801 sSGDESSySNCVPID NRIP1_repr_2 X X +SYK Syk P43405 human DBNL 13169 Q62418 Dbnl mouse Y350 450091 PPEQDTLyEEPPLVQ X +SYK Syk P43405 human CBL 867 P22681 CBL human Y774 448531 sENEDDGyDVPKPPV X 3555 +SYK Syk P43405 human DUSP3 1845 P51452 DUSP3 human Y38 459626 NEVTPRIyVGNASVA DSPc X X +SYK Syk P43405 human GCET2 257144 Q8N6F7 GCSAM human Y107 454098 GNsAEEyyENVPCkA HGAL X X +SYK Syk P43405 human CBL 867 P22681 CBL human Y731 448530 QQIDSCTyEAMyNIQ X 3554 +SYK Syk P43405 human BLNK 29760 Q8WV28 BLNK human Y72 447718 SDDFDSDyENPDEHS X X +SYK Syk P43405 human LAX1 54900 Q8IWV1 LAX1 human Y373 460158 SNEDSSDyENVLTAK LAX X +SYK Syk P43405 human Tau 4137 P10636 MAPT human Y18 454024 MEDHAGTyGLGDRKD X X +SYK Syk P43405 human GCET2 257144 Q8N6F7 GCSAM human Y80 449472 QDNVDQtysEELCyt HGAL X +SYK Syk P43405 human Syk 6850 P43405 SYK human Y525 447661 ALRADENyykAQtHG PK_Tyr_Ser-Thr X X 2711; 2710; 12967; 5514; 4349; 6485; 12081; 46994; 16859 +SYK Syk P43405 human SHP-2 5781 Q06124 PTPN11 human Y542 448492 sKRkGHEytNIKysL X 3751; 94740; 15543; 64117 +SYK Syk P43405 human RHBG 57127 Q9H310 RHBG human Y429 3647000 SPPDSQHyEDQVHWQ X +SYK Syk P43405 human Syk 25155 Q64725 Syk rat Y519 447661 ALRADENyyKAQTHG PK_Tyr_Ser-Thr X 2710; 12967; 5514; 4349; 6485; 12081; 46994; 16859 +SYK Syk P43405 human SLP76 3937 Q13094 LCP2 human Y113 448218 ssFEEDDyESPNDDQ X +SYK Syk P43405 human Syk 6850 P43405 SYK human Y526 447662 LRADENyykAQtHGK PK_Tyr_Ser-Thr X X 2711; 2710; 12967; 5514; 4349; 6485; 12081; 46994; 16859 +SYK Syk P43405 human Syk 20963 P48025 Syk mouse Y346 447660 TEVyESPyADPEEIR X 2701; 2717; 14791; 73382; 82975; 31754 +SYK Syk P43405 human BLNK 29760 Q8WV28 BLNK human Y189 447717 VEDNDENyIHPtESS X +SYK Syk P43405 human HS1 3059 P14317 HCLS1 human Y397 451636 EDEPEGDyEEVLEPE X X 4507; 8714; 13708; 11880 +SYK Syk P43405 human DOCK2 1794 Q92608 DOCK2 human Y1405 1876205002 VkNAPGQyIQCFTVQ DHR-2_Lobe_B X +SYK Syk P43405 human STAT1 6772 P42224 STAT1 human Y701 447754 DGPkGtGyIktELIs X 9174; 9167; 5375; 25685; 8062; 8183; 8009; 55603; 7649; 25809; 57216; 45118; 39205; 88845; 88211; 76285; 90145 +SYK Syk P43405 human PIP5K1B 8395 O14986 PIP5K1B human Y105 9471801 FGIKPDDyLYSICSE X +SYK Syk P43405 human SLP76 3937 Q13094 LCP2 human Y128 448219 DGEDDGDyEsPNEEE X +SYK Syk P43405 human STING 340061 Q86WV6 STING1 human Y240 1875847400 AGIKDRVysNSIyEL TMEM173 X +SYK Syk P43405 human LAX1 54900 Q8IWV1 LAX1 human Y193 35546000 SSEDSHDyVNVPTAE LAX X +STK39 STLK3 Q9UEW8 human NKCC2 6557 Q13621 SLC12A1 human T105 458228 LQtFGHNtMDAVPKI AA_permease_N X +STK39 STLK3 Q9UEW8 human SLC4A4 8671 Q9Y6R1 SLC4A4 human S65 4699735 ERIsENysDKsDIEN X +STK39 STLK3 Q9UEW8 human NKCC1 6558 P55011 SLC12A2 human T207 467236 YYDtHTNtyYLRtFG AA_permease_N X +STK39 STLK3 Q9UEW8 human NKCC1 6558 P55011 SLC12A2 human T203 467235 HQHYYYDtHTNtyYL AA_permease_N X +STK39 STLK3 Q9UEW8 human KCC3 9990 Q9UHW9 SLC12A6 human T1048 4770548 YQEKVHMtWTKDKYM SLC12 X +STK39 STLK3 Q9UEW8 human NKCC2 6557 Q13621 SLC12A1 human T95 4708938 AYDsHTNtYYLQtFG AA_permease_N X X +STK39 STLK3 Q9UEW8 human KCC3 9990 Q9UHW9 SLC12A6 human S96 10787161 IEDLSQNsITGEHSQ X X +STK39 STLK3 Q9UEW8 human NKCC2 6557 Q13621 SLC12A1 human T100 458227 TNtYYLQtFGHNtMD AA_permease_N X X +STK39 STLK3 Q9UEW8 human NKCC1 20496 P55012 Slc12a2 mouse T205 455545 TNtYYLRtFGHNtMD AA_permease_N X X +STK39 STLK3 Q9UEW8 human NCCT 6559 P55017 SLC12A3 human T60 469617 MRtFGYNtIDVVPtY AA_permease_N X +STK39 STLK3 Q9UEW8 human NCCT 6559 P55017 SLC12A3 human T46 2286406 SSHPSHLtHSStFCM AA_permease_N X +STK39 STLK3 Q9UEW8 human NCCT 6559 P55017 SLC12A3 human T55 469616 SStFCMRtFGYNtID AA_permease_N X +STK39 STLK3 Q9UEW8 human NKCC1 20496 P55012 Slc12a2 mouse T210 455546 LRtFGHNtMDAVPRI AA_permease_N X +STK39 STLK3 Q9UEW8 human Snail1 6615 O95863 SNAI1 human T203 21400402 QGHVRtHtGEkPFSC X +STK39 STLK3 Q9UEW8 human NKCC1 6558 P55011 SLC12A2 human T212 455545 TNtyYLRtFGHNtMD AA_permease_N X +HUNK HUNK P57058 human ITM2A 9452 O43736 ITM2A human T35 1869192400 TVRTQILtGkELRVA X X +Lyn LYN Q07014 rat FAK 25614 O35346 Ptk2 rat Y577 447890 yMEDstyyKAsKGKL PK_Tyr_Ser-Thr X 3281 +Lyn LYN Q07014 rat Syk 25155 Q64725 Syk rat Y346 447660 TEVyESPyADPEEIR X 2701; 2717; 14791; 73382; 82975; 31754 +Lyn LYN Q07014 rat GRP58 29468 P11598 Pdia3 rat Y467 453430 KKLTPKKyEGGRELN Thioredoxin X +Lyn LYN Q07014 rat GRP58 29468 P11598 Pdia3 rat Y454 453429 VkGFPTIyFsPANKK Thioredoxin X +Lyn LYN Q07014 rat CK2A1 1457 P68400 CSNK2A1 human Y255 450324 VLGTEDLyDyIDkYN Pkinase X +Lyn LYN Q07014 rat GRP58 29468 P11598 Pdia3 rat Y445 453428 ANDVPSPyEVkGFPT Thioredoxin X +Lyn LYN Q07014 rat HS1 3059 P14317 HCLS1 human Y222 452057 MEAPttAykkTTPIE X +Lyn LYN Q07014 rat FAK 25614 O35346 Ptk2 rat Y576 447889 RyMEDstyyKAsKGK PK_Tyr_Ser-Thr X 3281 +Myo3a MYO3A Q8K3H5 mouse MYO3A 667663 Q8K3H5 Myo3a mouse T184 29674700 sTRHRLNtSVGTPFW Pkinase X +Myo3a MYO3A Q8K3H5 mouse MYO3A 667663 Q8K3H5 Myo3a mouse S177 36841902 GVSAQLSsTRHRLNt Pkinase X +Myo3a MYO3A Q8K3H5 mouse MYO3A 667663 Q8K3H5 Myo3a mouse S332 36841903 KKGNLNRsLISSLKD X +Myo3a MYO3A Q8K3H5 mouse MYO3A 667663 Q8K3H5 Myo3a mouse S313 36841904 DIHQCLGsTEKARHE X +Prkci PKCI Q62074 mouse LLGL1 3996 Q15334 LLGL1 human S663 449917 LkKsLRQsFRRIRKs X X +Prkci PKCI Q62074 mouse Fe65 11785 Q9QXJ1 Apbb1 mouse S459 13309858 VWGVGRDsGSNRDFA PID X +Prkci PKCI Q62074 mouse RIC8A 101489 Q3TIR3 Ric8a mouse S501 3213318 VIQPMGMsPRGHLTS Ric8 X X +Prkci PKCI Q62074 mouse LLGL2 3993 Q6P1M3 LLGL2 human S653 13197200 LkKsLRQsFRRMRRS X +Cdk7 CDK7 Q03147 mouse POLR2A 20020 P08775 Polr2a mouse S1619 447616 SPSYsPtsPSYSPTS RNA_pol_Rpb1_R X 4735; 13523; 13546; 67221 +IRAK1 IRAK1 P51617 human PELI1 57162 Q96FA3 PELI1 human T80 7388010 DQHsIsYtLsRAQtV Pellino X +IRAK1 IRAK1 P51617 human IRAK1 3654 P51617 IRAK1 human T387 447721 RtQTVRGtLAYLPEE Pkinase X +IRAK1 IRAK1 P51617 human PELI1 57162 Q96FA3 PELI1 human S78 7388013 NKDQHsIsYtLsRAQ Pellino X +IRAK1 IRAK1 P51617 human PELI1 57162 Q96FA3 PELI1 human T86 7388011 YtLsRAQtVVVEYTH Pellino X +IRAK1 IRAK1 P51617 human PELI1 57162 Q96FA3 PELI1 human T288 7388016 QCPVGFNtLAFPsMk Pellino X +IRAK1 IRAK1 P51617 human PELI1 57162 Q96FA3 PELI1 human T127 7452903 GSQSNsDtQSVQSTI Pellino X +IRAK1 IRAK1 P51617 human PELI2 57161 Q9HAT8 PELI2 human T290 5860078 QCPVGLNtLAFPsIN Pellino X +IRAK1 IRAK1 P51617 human IRAK1 3654 P51617 IRAK1 human T209 450949 LCEISRGtHNFSEEL X +IRAK1 IRAK1 P51617 human PELI1 57162 Q96FA3 PELI1 human S293 7388014 FNtLAFPsMkRkDVV Pellino X +IRAK1 IRAK1 P51617 human PELI1 57162 Q96FA3 PELI1 human S125 18122803 VPGSQSNsDtQSVQS Pellino X +IRAK1 IRAK1 P51617 human STAT3 6774 P40763 STAT3 human S727 448191 NtIDLPMsPrTLDSL X 9134; 9136; 34911; 94994; 49081; 58978; 87544; 71958; 50804 +IRAK1 IRAK1 P51617 human PELI1 57162 Q96FA3 PELI1 human S76 7388015 IsNKDQHsIsYtLsR Pellino X +IRAK1 IRAK1 P51617 human USP20 74270 Q8C6M1 Usp20 mouse S334 7323248 RMKDRKFsWGQQRTN X X +IRAK1 IRAK1 P51617 human PELI1 57162 Q96FA3 PELI1 human S82 7388012 HsIsYtLsRAQtVVV Pellino X +IRAK1 IRAK1 P51617 human PELI1 57162 Q96FA3 PELI1 human S70 7452902 PQAAKAIsNKDQHsI Pellino X +CDKL5 CDKL5 O76039 human TNRC18 84629 O15417 TNRC18 human S660 50801529 RDPERPEsAkAFGRE X +CDKL5 CDKL5 O76039 human TTDN1 136647 Q8TAP9 MPLKIP human S40 6422892 GGGPrPPsPrDGyGs X +CDKL5 CDKL5 O76039 human LRRC4C 57689 Q9HCJ2 LRRC4C human S631 3893278 PLLIRMNsKDNVQET X X +CDKL5 CDKL5 O76039 human RP1 10982 Q15555 MAPRE2 human S223 476320 stPsRPssAkRASSS X +CDKL5 CDKL5 O76039 human PPP1R26 9858 Q5T8A7 PPP1R26 human T606 1875006602 GGHVRPStPKKMQEV PPP1R26_N X +CDKL5 CDKL5 O76039 human TCEB3 6924 Q14241 ELOA human S285 18914150 EENRRPPsGDNAREK X X +CDKL5 CDKL5 O76039 human hnRNP F 3185 P52597 HNRNPF human T215 23113704 GPyDrPGtArryIGI X +CDKL5 CDKL5 O76039 human ZC3H14 79882 Q6PJT7 ZC3H14 human T734 15503934 LkWIRPQtsE_____ X +CDKL5 CDKL5 O76039 human RPL13 6137 P26373 RPL13 human S52 27460376 RIAPRPAsGPIRPIV Ribosomal_L13e X +CDKL5 CDKL5 O76039 human CEP131 22994 Q9UPN4 CEP131 human S35 27444528 PVSRRPGsAATTkPI X X +CDKL5 CDKL5 O76039 human PHF23 79142 Q9BUL5 PHF23 human S400 25174009 RLGGPPKsGEP____ X +CDKL5 CDKL5 O76039 human ZNF192 7745 Q15776 ZKSCAN8 human S141 1875006800 DILGRPVsARVHGHR X +CDKL5 CDKL5 O76039 human ZAP3 56252 P49750 YLPM1 human S1089 18017826 GLVrPGssREKVPGG X +CDKL5 CDKL5 O76039 human VIRMA 25962 Q69YN4 VIRMA human S1759 30990559 LPPLRPLsSTGYRPs X +CDKL5 CDKL5 O76039 human CDKL5 6792 O76039 CDKL5 human Y171 454076 NNANytEyVATRWYR Pkinase X X +CDKL5 CDKL5 O76039 human ZAP3 56252 P49750 YLPM1 human S1088 31086542 rGLVrPGssREKVPG X +CDKL5 CDKL5 O76039 human RBMX 27316 P38159 RBMX human S261 18913016 DyPsrGysDrDGyGR X +CDKL5 CDKL5 O76039 human ZNF592 9640 Q92610 ZNF592 human S1100 22780931 NHLKRPVsGVGDAPG X +CDKL5 CDKL5 O76039 human amphiphysin 218038 Q7TQF7 Amph mouse S293 465542 PAPVRPRsPsQtRKG X +CDKL5 CDKL5 O76039 human BPY2-IP1 55201 Q66K74 MAP1S human S900 476391 DrAsRPLsARsEPsE X X +CDKL5 CDKL5 O76039 human CDKL5 6792 O76039 CDKL5 human T169 1868100 EGNNANytEyVATRW Pkinase X +CDKL5 CDKL5 O76039 human MAP1A 4130 P78559 MAP1A human S900 456391 GtIsPtssLEEDKGF X +CDKL5 CDKL5 O76039 human DLG5 9231 Q8TDM6 DLG5 human S1115 9411518 QKRRRPKsAPSFRPK X +CDKL5 CDKL5 O76039 human smoothelin 6525 P53814 SMTN human S139 27457326 LYSGRPNsGSREDSK X +CDKL5 CDKL5 O76039 human claspin 63967 Q9HAW4 CLSPN human S1246 1875006600 FEAIRPGsAQQVKTG X +CDKL5 CDKL5 O76039 human treacle 6949 Q13428 TCOF1 human S801 476275 PAAARAPsAKGtISA Treacle X +CDKL5 CDKL5 O76039 human p400 57634 Q96L91 EP400 human S729 10371268 sPVNRPssAtNkALs X X +Prkacb PKACB P68181 mouse NKX2-1 25628 P23441 Nkx2-1 rat T9 451108 SMSPKHTtPFsVSDI X X +Prkacb PKACB P68181 mouse TIAM2 24001 Q6ZPF3 Tiam2 mouse T749 15503728 DSTLRKRtLsLTQRG X +MAPK11 P38B Q15759 human p300 2033 Q09472 EP300 human S12 25126714 VVEPGPPsAkRPKLs X +MAPK11 P38B Q15759 human ATF-2 1386 P15336 ATF2 human T69 448224 sVIVADQtPtPtRFL X X 9225; 94125; 40749; 61584; 44167 +MAPK11 P38B Q15759 human ATF-2 1386 P15336 ATF2 human T71 448225 IVADQtPtPtRFLkN X X 9225; 9221; 5112; 94125; 13850; 40749; 15411; 24329; 61584; 27934; 92109; 20534; 35858 +MAPK11 P38B Q15759 human SOD2 6648 P04179 SOD2 human T79 62403300 ALAKGDVtAQIALQP Sod_Fe_N X X +MAPK11 P38B Q15759 human P38B 5600 Q15759 MAPK11 human T241 54390600 RIMEVVGtPsPEVLA Pkinase X +MAPK11 P38B Q15759 human PIAS2 83422 Q6AZ28 Pias2 rat S116 464654 IAPHsPSsPVASVLL X X +MAPK11 P38B Q15759 human SNX27 81609 Q96L92 SNX27 human S51 486072 VRIVksEsGYGFNVR PDZ X X +MAPK11 P38B Q15759 human EEF2K 29904 O00418 EEF2K human S396 450812 TFDsLPssPssAtPH X +MAPK11 P38B Q15759 human HSF1 3297 Q00613 HSF1 human S307 449046 EPPsPPQsPRVEEAs Vert_HS_TF X +MAPK11 P38B Q15759 human Raptor 57521 Q8N122 RPTOR human S771 13251700 SASSTLGsPENEEHI X X +MAPK11 P38B Q15759 human E2F1 1869 Q01094 E2F1 human T433 447871 DCDFGDLtPLDF___ X +MAPK11 P38B Q15759 human EGFR 1956 P00533 EGFR human S1039 3178884 tPLLSsLsAtsNNst X +MAPK11 P38B Q15759 human Raptor 57521 Q8N122 RPTOR human S863 453732 LtQsAPAsPtNkGVH X X +MAPK11 P38B Q15759 human MAPKAPK5 8550 Q8IW41 MAPKAPK5 human T182 450093 IDQGDLMtPQFtPyY Pkinase X +MAPK11 P38B Q15759 human P38B 5600 Q15759 MAPK11 human S261 54390601 HARTYIQsLPPMPQK Pkinase X +MAPK11 P38B Q15759 human NALP1 22861 Q9C000 NLRP1 human S107 1880261804 PSEPHLGsPSQPTST X +MAPK11 P38B Q15759 human CDC25B 994 P30305 CDC25B human S249 469600 kMEVEELsPLALGRF M-inducer_phosp X +MAPK11 P38B Q15759 human HSF1 3297 Q00613 HSF1 human S303 449045 RVkEEPPsPPQsPRV Vert_HS_TF X +MAPK11 P38B Q15759 human Tip60 iso2 10524 Q92993-2 KAT5 human T106 10800707 VEVVsPAtPVPSETA X +MAPK11 P38B Q15759 human HNF4 alpha 3172 P41235 HNF4A human S167 458371 VLSRQItsPVsGING X +MAPK11 P38B Q15759 human SOD2 6648 P04179 SOD2 human S106 7577901 SIFWTNLsPNGGGEP Sod_Fe_N X X +MAPK11 P38B Q15759 human EGFR 1956 P00533 EGFR human T1041 3178896 LLSsLsAtsNNstVA X +MAPK11 P38B Q15759 human ATF7 11016 P17544 ATF7 human T51 467515 sVIIADQtPtPtRFL X 94125; 40749; 61584; 44167 +MAPK11 P38B Q15759 human GYS1 2997 P13807 GYS1 human S727 457615 StPsEPLsPtssLGE X +MAPK11 P38B Q15759 human HSF1 3297 Q00613 HSF1 human S326 455484 ssVDtLLsPTALIDs Vert_HS_TF X +MAPK11 P38B Q15759 human TFEB 21425 Q9R210 Tfeb mouse S400 1880515602 LDFSHGLsFGGGGDE X +MAPK11 P38B Q15759 human GYS1 2997 P13807 GYS1 human T721 457616 AtsssLStPsEPLsP X +MAPK11 P38B Q15759 human PKCE 5581 Q02156 PRKCE human S350 486055 RsKsAPtsPCDQEIK X +MAPK11 P38B Q15759 human GYS1 2997 P13807 GYS1 human S653 448240 PsLsRHssPHQsEDE Glycogen_syn X +MAPK11 P38B Q15759 human GYS1 2997 P13807 GYS1 human S645 448238 RPAsVPPsPsLsRHs Glycogen_syn X +MAPK11 P38B Q15759 human SREBP-1 6720 P36956 SREBF1 human S63 23940711 AGGtDPAsPDTSSPG X +MAPK11 P38B Q15759 human E2F1 1869 Q01094 E2F1 human S403 447870 PEEFISLsPPHEALD X +MAPK11 P38B Q15759 human EWS 2130 Q01844 EWSR1 human T79 7359501 QPPTGYTtPTAPQAY X +MAPK11 P38B Q15759 human SREBP-1 6720 P36956 SREBF1 human T426 467200 TEVEDTLtPPPsDAG X +MAPK11 P38B Q15759 human CCND3 896 P30281 CCND3 human T283 452160 QGPsQtstPtDVtAI X 53966 +MAPK11 P38B Q15759 human Tip60 10524 Q92993 KAT5 human T158 10800707 VEVVsPAtPVPSETA X +MAPK11 P38B Q15759 human GR 2908 P04150 NR3C1 human S226 451796 IDENCLLsPLAGEDD GCR X 97285 +MAPK11 P38B Q15759 human STAT1 20846 P42225 Stat1 mouse S727 447753 tDNLLPMsPEEFDEM STAT1_TAZ2bind X X 9177; 8826; 62390 +MAPK11 P38B Q15759 human PIAS2 83422 Q6AZ28 Pias2 rat S113 464653 STSIAPHsPSsPVAS X X +MAPK11 P38B Q15759 human SMARCD3 66993 Q6P9Z1 Smarcd3 mouse T229 8097074 HLVEWHRtPTTQETD X +ERBB4 HER4 Q15303 human HER4 2066 Q15303 ERBB4 human Y1056 451500 GHsPPPAyTPMSGNQ X +ERBB4 HER4 Q15303 human HER4 2066 Q15303 ERBB4 human Y1162 2045347 RDKPKQEyLNPVEEN X +ERBB4 HER4 Q15303 human HER4 2066 Q15303 ERBB4 human Y1284 457470 IVAENPEyLSEFSLK X 4757 +RPS6KA6 RSK4 Q9UK32 human RSK4 27330 Q9UK32 RPS6KA6 human S232 457600 DQEKKAysFCGtVEy Pkinase X X +RPS6KA6 RSK4 Q9UK32 human p300 2033 Q09472 EP300 human S89 447592 SELLRSGsSPNLNMG X X +STYK1 STYK1 Q6J9G0 human beclin 1 8678 Q14457 BECN1 human S93 5473540 ARMMstEsANsFTLI X 14717 +STYK1 STYK1 Q6J9G0 human beclin 1 8678 Q14457 BECN1 human S90 472001 IPPARMMstEsANsF X 29362; 86455 +Tlk2 TLK2 O55047 mouse ASF1A 66403 Q9CQE6 Asf1a mouse S166 3245981 kLEDAEssNPNLQSL X +MAPK4 ERK4 P31152 human Akt1 207 P31749 AKT1 human T308 447856 kDGAtMKtFCGtPEy Pkinase X 5106; 2965; 9275; 4056; 5056; 13842; 13038; 43506; 48646; 86758; 80722; 77440; 80556 +PINK1 PINK1 Q9BXM7 human PARK2 50873 Q9WVS6 Prkn mouse S65 25538008 NCDLEQQsIVHIVQR ubiquitin X +PINK1 PINK1 Q9BXM7 human PARIS 155061 Q6NUN9 ZNF746 human S322 27533659 QATRFFPsPAQEGAW X +PINK1 PINK1 Q9BXM7 human PINK1 68943 Q99MQ3 Pink1 mouse S411 1883601200 VERGGNGsLMAPEVS Pkinase X +PINK1 PINK1 Q9BXM7 human LETM1 3954 O95202 LETM1 human T192 384464302 ILNGHsLtRRERRQF LETM1_RBD X +PINK1 PINK1 Q9BXM7 human MFN2 9927 O95140 MFN2 human S442 4746700 AEEIRRLsVLVDDYQ X +PINK1 PINK1 Q9BXM7 human PARK2 56816 Q9JK66 Prkn rat S65 25538008 NCDLEQQsIVHIVQR ubiquitin X +PINK1 PINK1 Q9BXM7 human PINK1 65018 Q9BXM7 PINK1 human S402 25792201 GLQLPFSsWYVDRGG Pkinase X X +PINK1 PINK1 Q9BXM7 human EFTU 7284 P49411 TUFM human S222 1871246005 ETPVIVGsALCALEG GTP_EFTU X X +PINK1 PINK1 Q9BXM7 human PINK1 65018 Q9BXM7 PINK1 human T257 25544600 AGEYGAVtYRKSkRG X X +PINK1 PINK1 Q9BXM7 human PINK1 65018 Q9BXM7 PINK1 human S228 25792200 MWNISAGsSSEAILN X X 89010; 46421 +PINK1 PINK1 Q9BXM7 human JUB 84962 Q96IF1 AJUBA human S39 18011036 GPGKGRLsGLGGPRK X +PINK1 PINK1 Q9BXM7 human FAM65B 193385 Q80U16 Ripor2 mouse S46 4746003 NGIIRsQsFAGFSGL PL48 X X +PINK1 PINK1 Q9BXM7 human ubiquitin P62991 UBA52-RPS27A-UBB-UBC mouse S65 9765472 DYNIQkEstLHLVLR ubiquitin X X 43163; 37642; 62802; 70973; 83816; 88503 +PINK1 PINK1 Q9BXM7 human ubiquitin P62988 UBA52-RPS27A-UBB-UBC human S65 9765472 DyNIQkEstLHLVLr ubiquitin X X 43163; 37642; 62802; 70973; 83816; 88503 +PINK1 PINK1 Q9BXM7 human MFN2 9927 O95140 MFN2 human T111 17402150 RTSNGKStVINAMLW Dynamin_N X +PINK1 PINK1 Q9BXM7 human MFN2 9927 O95140 MFN2 human S378 1877509600 AVRLIMDsLHMAARE X +PINK1 PINK1 Q9BXM7 human RHOT1 55288 Q8IXI2 RHOT1 human S156 21587701 AKNLkNIsELFyYAQ Ras X +PINK1 PINK1 Q9BXM7 human ubiquitin P62991 UBA52-RPS27A-UBB-UBC mouse T66 31728103 YNIQkEstLHLVLRL ubiquitin X +PINK1 PINK1 Q9BXM7 human Bcl-xL 598 Q07817 BCL2L1 human S62 449099 PSWHLADsPAVNGAT X +PINK1 PINK1 Q9BXM7 human PARK2 5071 O60260 PRKN human S65 25538008 NCDLDQQsIVHIVQR ubiquitin X X 36866 +PINK1 PINK1 Q9BXM7 human HIF3A iso2 53417 Q0VBL6-2 Hif3a mouse T12 57786401 LQRVRsNtELRKEKS X +PINK1 PINK1 Q9BXM7 human PARIS 155061 Q6NUN9 ZNF746 human S613 25759828 APPDPFKsPAsKGPL X +PINK1 PINK1 Q9BXM7 human EEF1A1 1915 P68104 EEF1A1 human S396 31884110 DGPkFLksGDAAIVD GTP_EFTU_D3 X X +PINK1 PINK1 Q9BXM7 human NEDD8 4738 Q15843 NEDD8 human S65 4705608 DykILGGsVLHLVLA ubiquitin X +PINK1 PINK1 Q9BXM7 human ubiquitin P62988 UBA52-RPS27A-UBB-UBC human T66 31728103 yNIQkEstLHLVLrL ubiquitin X +PINK1 PINK1 Q9BXM7 human UBA52 7311 P62987 UBA52 human S65 9765474 DyNIQkEstLHLVLr ubiquitin X X 43163; 37642; 62802; 70973; 83816; 88503 +EPHA5 EphA5 P54756 human GLO1 2739 Q04760 GLO1 human Y136 463450 GIAVPDVysACkRFE Glyoxalase X X +Cdk2 CDK2 Q63699 rat PKLR iso2 24651 P12928-2 Pklr rat S113 31084572 ATESFATsPLSYRPV PK X +Ret Ret G3V9H8 rat Ret 24716 G3V9H8 Ret rat Y1063 447625 TWIENKLyGMSDPNW X +Ret Ret G3V9H8 rat Ret 24716 G3V9H8 Ret rat Y1097 449891 RYANDSVyANWMVSP X +Ret Ret G3V9H8 rat Ret 24716 G3V9H8 Ret rat Y906 447627 DVYEEDSyVKKSKGR PK_Tyr_Ser-Thr X +Ret Ret G3V9H8 rat Ret 24716 G3V9H8 Ret rat Y1016 449894 MMVKSRDyLDLAAST X +Kdr VEGFR2 P35918 mouse VEGFR2 16542 P35918 Kdr mouse Y1212 447902 VCDPKFHyDNTAGIS X 2477 +Kdr VEGFR2 P35918 mouse VEGFR3 14257 P35917 Flt4 mouse Y1265 10799700 LPMTPTTyKASMDNQ X +Kdr VEGFR2 P35918 mouse VEGFR2 16542 P35918 Kdr mouse Y949 447903 RFRQGkDyVGELSVD PK_Tyr_Ser-Thr X 2476; 2471; 4991 +Kdr VEGFR2 P35918 mouse VEGFR3 14257 P35917 Flt4 mouse Y1230 4119675 CHSLAARyyNCVSFP X +Kdr VEGFR2 P35918 mouse VEGFR3 14257 P35917 Flt4 mouse Y1231 4119681 HSLAARyyNCVSFPG X +Kdr VEGFR2 P35918 mouse VEGFR2 16542 P35918 Kdr mouse Y1052 447899 FGLARDIykDPDyVR PK_Tyr_Ser-Thr X +Egfr EGFR Q9QX70 rat EGFR 24329 Q9QX70 Egfr rat Y1196 448060 PTAENAEyLRVAPPS X 4407; 47737 +Egfr EGFR Q9QX70 rat ERK2 5594 P28482 MAPK1 human T185 447593 HDHtGFLtEyVAtRW Pkinase X 9106; 4370; 4374; 9101; 4375; 4376; 4377; 3510; 5726; 88569; 13214; 13148; 70235; 9488; 89967; 8544; 14196; 14227; 14095; 14474; 75165; 98168; 33370; 54240; 15892; 45899; 55088; 9524; 69217; 48735 +Egfr EGFR Q9QX70 rat ERK1 5595 P27361 MAPK3 human T202 447542 HDHtGFLtEyVAtRW Pkinase X 9106; 4370; 4374; 9101; 4375; 4376; 4377; 3510; 5726; 88569; 13214; 13148; 70235; 9488; 89967; 8544; 14196; 14227; 14095; 14474; 75165; 98168; 33370; 54240; 15892; 45899; 55088; 9524; 69217; 48735 +Egfr EGFR Q9QX70 rat ERK2 5594 P28482 MAPK1 human Y187 447594 HtGFLtEyVAtRWyr Pkinase X 9106; 4370; 4374; 9101; 4375; 4376; 4377; 3510; 5726; 88569; 13214; 13148; 70235; 9488; 89967; 8544; 14196; 14227; 14095; 14474; 75165; 98168; 33370; 54240; 15892; 45899; 55088; 9524; 69217; 48735 +Egfr EGFR Q9QX70 rat ERK1 5595 P27361 MAPK3 human Y204 447543 HtGFLtEyVAtRWyr Pkinase X 9106; 4370; 4374; 9101; 4375; 4376; 4377; 3510; 5726; 88569; 13214; 13148; 70235; 9488; 89967; 8544; 14196; 14227; 14095; 14474; 75165; 98168; 33370; 54240; 15892; 45899; 55088; 9524; 69217; 48735 +RAF1 RAF1 P04049 human RAF1 5894 P04049 RAF1 human S621 447746 PKINRsAsEPsLHRA X X +RAF1 RAF1 P04049 human KLF10 7071 Q13118 KLF10 human T93 23119614 TIPAFCLtPPYsPSD X X +RAF1 RAF1 P04049 human BAD 572 Q92934 BAD human S75 447860 EIRsRHssyPAGtED Bcl-2_BAD X X 9291; 5284; 9296; 5193; 11865; 94223 +RAF1 RAF1 P04049 human ADCY6 25289 AAA40678 Adcy6 rat S746 467273 ALQRLsRsIVRsRVH X +RAF1 RAF1 P04049 human ADCY6 25289 AAA40678 Adcy6 rat S754 467275 IVRsRVHsTAVGVFS X +RAF1 RAF1 P04049 human BAD 572 Q92934 BAD human S118 447863 GRELRRMsDEFVDsF Bcl-2_BAD X X 9297 +RAF1 RAF1 P04049 human ADCY6 25289 AAA40678 Adcy6 rat S750 467274 LsRsIVRsRVHsTAV X +RAF1 RAF1 P04049 human MEK1 5604 Q02750 MAP2K1 human S222 448513 LIDsMANsFVGtRSY Pkinase X X 2338; 9121; 3958; 9154; 16211; 86128; 16780; 75262 +RAF1 RAF1 P04049 human TNNT2 24837 P50753 Tnnt2 rat T214 451556 RKsGKRQtEREKKKK Troponin X +RAF1 RAF1 P04049 human RAF1 5894 P04049 RAF1 human S359 28070702 StRIGsGsFGtVYkG PK_Tyr_Ser-Thr X +RAF1 RAF1 P04049 human BAD 12015 Q61337 Bad mouse S112 447860 ETRsRHssyPAGtEE Bcl-2_BAD X 9291; 5284; 9296; 5193; 11865; 94223 +RAF1 RAF1 P04049 human EEF1A2 1917 Q05639 EEF1A2 human S21 5434143 GHVDSGkstttGHLI GTP_EFTU X +RAF1 RAF1 P04049 human MEK1 5604 Q02750 MAP2K1 human S218 448514 VsGQLIDsMANsFVG Pkinase X X 9121; 3958; 9154; 86128 +RAF1 RAF1 P04049 human RAF1 5894 P04049 RAF1 human S259 447741 sQRQRststPNVHMV X 9421; 20011 +RAF1 RAF1 P04049 human Myc 4609 P01106 MYC human T23 448497 MPLNVsFtNRNyDLD Myc_N X +RAF1 RAF1 P04049 human RAF1 5894 P04049 RAF1 human S338 447742 RPRGQRDssyyWEIE X 9427 +RAF1 RAF1 P04049 human BAD 572 Q92934 BAD human S99 447862 PFrGrsRsAPPNLWA Bcl-2_BAD X 9295; 5286; 4366 +RAF1 RAF1 P04049 human ADCY6 25289 AAA40678 Adcy6 rat S744 467272 PNALQRLsRsIVRsR X +RAF1 RAF1 P04049 human MYPT1 4659 O14974 PPP1R12A human T696 448587 ARQsRRstQGVtLtD X 5163 +Rps6ka4 MSK2 Q9Z2B9 mouse H3 360198 P68433 H3c1 mouse S10 455676 tkQTARkstGGkAPr Histone X 9701; 9711; 9606; 3465; 3642; 3377; 3475; 3458; 5764; 47398; 8481; 8552; 53348; 29237; 66065; 43185; 64522; 52725 +NME1 NME1 P15531 human NME1 4830 P15531 NME1 human H118 474528 QVGRNIIhGsDsVEs NDK X X +NME1 NME1 P15531 human KSR 16706 Q61097 Ksr1 mouse S434 456128 LDSSSNPsSTTSSTP X X +NME1 NME1 P15531 human ACLY 24159 P16638 Acly rat H759 9643000 SSEVQFGhAGACANQ Ligase_CoA X +NME1 NME1 P15531 human NME1 4830 P15531 NME1 human S44 450096 GLkFMQAsEDLLkEH NDK X +NME1 NME1 P15531 human PGAM1 5223 P18669 PGAM1 human H11 27939200 YkLVLIRhGEsAWNL His_Phos_1 X +NME1 NME1 P15531 human NME1 4830 P15531 NME1 human S120 450098 GRNIIhGsDsVEsAE NDK X +NME1 NME1 P15531 human KSR 16706 Q61097 Ksr1 mouse S392 449297 ARLRRtEsVPsDINN X X 4951 +MYLK3 caMLCK Q32MK0 human PPP1R2 192361 P50411 Ppp1r2 rat S44 2231000 EEELSKKsQKWDEMN X +MYLK3 caMLCK Q32MK0 human MRLC3 10627 P19105 MYL12A human S19 7382102 KRPQRAtsNVFAMFD X +MYLK3 caMLCK Q32MK0 human MEF2C 4208 Q06413 MEF2C human T80 19083402 NEPHESRtNsDIVEt X +MYLK3 caMLCK Q32MK0 human MRLC2V 17906 P51667 Myl2 mouse S15 2846506 kRIEGGssNVFsMFE X +MYLK3 caMLCK Q32MK0 human TNNI3 7137 P19429 TNNI3 human S24 448424 APIRRRssNyRAyAt Troponin-I_N X 4004 +MYLK3 caMLCK Q32MK0 human MRLC3 10627 P19105 MYL12A human T18 7382101 KKRPQRAtsNVFAMF X +CDK11B CDK11B P21127 human AR 367 P10275 AR human S310 448413 TEDTAEysPFKGGYT Androgen_recep X X 61248 +CDK11B CDK11B P21127 human eIF3-epsilon 8665 O00303 EIF3F human S46 448818 PAAAPASsSDPAAAA X X +Gsk3b GSK3B Q9WV60 mouse NFkB-p105 4790 P19838 NFKB1 human S903 455617 KtTsQAHsLPLsPAs X X +Gsk3b GSK3B Q9WV60 mouse CRY2 12953 Q9R194 Cry2 mouse S553 456804 TGPRALSsGPAsPKR X X +Gsk3b GSK3B Q9WV60 mouse FTO 26383 Q8BGW1 Fto mouse S249 1115398000 YSYsCEGsEDEsEDE FTO_NTD X +Gsk3b GSK3B Q9WV60 mouse CCND1 12443 P25322 Ccnd1 mouse T286 447839 EEAGLACtPtDVRDV X X +Gsk3b GSK3B Q9WV60 mouse SOX11 20666 Q7M6Y2 Sox11 mouse S244 454322 SVAKVPAsPTLSSAA X +Gsk3b GSK3B Q9WV60 mouse C/EBP-beta 12608 P28033 Cebpb mouse T179 455887 GSsGsLStssSssPP X X +Gsk3b GSK3B Q9WV60 mouse CRMP-4 22240 Q62188 Dpysl3 mouse T509 454328 PVFDLtttPkGGtPA X +Gsk3b GSK3B Q9WV60 mouse MYO1C iso3 17913 Q9WTI7-3 Myo1c mouse S1020 34404301 DGIIDFTsGSELLIT Myosin_TH1 X X +Gsk3b GSK3B Q9WV60 mouse NRF2 18024 Q60795 Nfe2l2 mouse S335 18258505 MEFNDSDsGIsLNTs X X +Gsk3b GSK3B Q9WV60 mouse neurogenin 2 11924 P70447 Neurog2 mouse S231 2255101 SPYSCTLsPAsPGSD X +Gsk3b GSK3B Q9WV60 mouse Cbl-b 208650 Q3TTA7 Cblb mouse S480 4717392 RQNsPVtsPGssPLA X +Gsk3b GSK3B Q9WV60 mouse FTO 26383 Q8BGW1 Fto mouse S253 27449492 CEGsEDEsEDEsSFE FTO_NTD X +Gsk3b GSK3B Q9WV60 mouse CCND1 12443 P25322 Ccnd1 mouse T288 451435 AGLACtPtDVRDVDI X +Gsk3b GSK3B Q9WV60 mouse PLEKHO1 67220 Q9JIY0 Plekho1 mouse S341 12739074 KAKDPPQsPPDSESE X +Gsk3b GSK3B Q9WV60 mouse LPCAT1 210992 Q3TFD2 Lpcat1 mouse S178 17533100 RPVFVSRsDQDsRRK Acyltransferase X +Gsk3b GSK3B Q9WV60 mouse CTNNB1 12387 Q02248 Ctnnb1 mouse S37 447582 YLDsGIHsGATtTAP X X 9561; 2009; 4270; 13537; 41334; 60180 +Gsk3b GSK3B Q9WV60 mouse PTEN 19211 O08586 Pten mouse T366 449634 ASSSTSVtPDVsDNE X +Gsk3b GSK3B Q9WV60 mouse NRF2 18024 Q60795 Nfe2l2 mouse S355 18258504 PEHsVESsIYGDPPP X X +Gsk3b GSK3B Q9WV60 mouse NRF2 18024 Q60795 Nfe2l2 mouse S338 18258501 NDSDsGIsLNTsPSR X X +Gsk3b GSK3B Q9WV60 mouse VHL 22346 P40338 Vhl mouse S34 469116 PVLRSVNsREPSQVI VHL X +Gsk3b GSK3B Q9WV60 mouse MDM2 17246 P23804 Mdm2 mouse S240 454921 CLDQDsVsDQFsVEF X +Gsk3b GSK3B Q9WV60 mouse DHX33 216877 Q80VY9 Dhx33 mouse T482 1883375203 KDDQLTLtPIGRKMA X X +Gsk3b GSK3B Q9WV60 mouse CAP1 12331 P40124 Cap1 mouse S309 2525971 PKPQtsPsPKPAtKK X +Gsk3b GSK3B Q9WV60 mouse CTNNB1 12387 Q02248 Ctnnb1 mouse S45 447488 GATtTAPsLsGkGNP X 9565; 9564; 24710; 70034; 19807; 96727; 77605 +Gsk3b GSK3B Q9WV60 mouse CRMP-2 12934 O08553 Dpysl2 mouse T514 454386 sVtPktVtPAssAkt X 9397 +Gsk3b GSK3B Q9WV60 mouse MAP1B 17755 P14873 Map1b mouse T1265 455476 PPsPIEKtPLGERsV X +Gsk3b GSK3B Q9WV60 mouse NRF2 18024 Q60795 Nfe2l2 mouse S342 18258503 sGIsLNTsPSRAsPE X X +Gsk3b GSK3B Q9WV60 mouse MCL1 17210 P97287 Mcl1 mouse S140 460683 kSsGADGsLPStPPP X 4579 +Gsk3b GSK3B Q9WV60 mouse Tau 17762 P10637 Mapt mouse T497 447933 ssPGsPGtPGsRsRt X 25377; 43964; 53001; 49561; 20060; 33032; 30505; 20739; 98160 +Gsk3b GSK3B Q9WV60 mouse ULK1 22241 O70405 Ulk1 mouse S405 23070960 HGRTPsPsPTCSSSP X +Gsk3b GSK3B Q9WV60 mouse Myb 17863 P06876 Myb mouse T572 1308922 LTSSVLMtPVSEDED X +Gsk3b GSK3B Q9WV60 mouse Cbl-b 208650 Q3TTA7 Cblb mouse S476 3823372 KCTDRQNsPVtsPGs X +Gsk3b GSK3B Q9WV60 mouse neurogenin 2 11924 P70447 Neurog2 mouse S234 2255100 SCTLsPAsPGSDVDy X +Gsk3b GSK3B Q9WV60 mouse GSK3B 2932 P49841 GSK3B human Y216 448569 RGEPNVsyICsRyyR Pkinase X +Gsk3b GSK3B Q9WV60 mouse ULK1 22241 O70405 Ulk1 mouse S415 4958506 CSSSPSPsGRPGPFS X +Gsk3b GSK3B Q9WV60 mouse Tau 17762 P10637 Mapt mouse S494 447928 sGyssPGsPGtPGsR X 39357; 30505 +Gsk3b GSK3B Q9WV60 mouse MAP1B 17755 P14873 Map1b mouse S1260 454136 sLsPsPPsPIEKtPL X +Gsk3b GSK3B Q9WV60 mouse NRF2 18024 Q60795 Nfe2l2 mouse S347 18258502 NTsPSRAsPEHsVES X X +Gsk3b GSK3B Q9WV60 mouse SOX4 20677 Q06831 Sox4 mouse S316 41454646 GRSSAAssPAASRSP X +Gsk3b GSK3B Q9WV60 mouse PELP1 75273 Q9DBD5 Pelp1 mouse T751 453708 PVLAPsGtPPPsIPP X +Gsk3b GSK3B Q9WV60 mouse MDM2 17246 P23804 Mdm2 mouse S254 459215 FEVESLDsEDYsLSD X +Gsk3b GSK3B Q9WV60 mouse C/EBP-beta 12608 P28033 Cebpb mouse T188 447878 sSssPPGtPSPADAK X 3084 +Gsk3b GSK3B Q9WV60 mouse SOX4 20677 Q06831 Sox4 mouse S315 50800249 SGRSSAAssPAASRS X +Gsk3b GSK3B Q9WV60 mouse RCAN1 54720 Q9JHG6 Rcan1 mouse S165 456023 FLIsPPAsPPVGWKQ Calcipressin X +Gsk3b GSK3B Q9WV60 mouse CTNNB1 12387 Q02248 Ctnnb1 mouse S29 3075000 VsHWQQQsYLDsGIH X +Gsk3b GSK3B Q9WV60 mouse GSK3B 56637 Q9WV60 Gsk3b mouse Y216 448569 RGEPNVsyICsRYYR Pkinase X +Gsk3b GSK3B Q9WV60 mouse SIRT7 209011 Q8BKJ9 Sirt7 mouse T256 1874512902 PLNWEAAtEAAsKAD SIR2 X +Gsk3b GSK3B Q9WV60 mouse C/EBP-beta 12608 P28033 Cebpb mouse S184 455886 LStssSssPPGtPSP X X +Gsk3b GSK3B Q9WV60 mouse Tau 17762 P10637 Mapt mouse S491 447927 GERsGyssPGsPGtP X 29957 +Gsk3b GSK3B Q9WV60 mouse DZIP1 66573 Q8BMD2 Dzip1 mouse S520 40586900 KPSSTSPsPQELRTN X X +Gsk3b GSK3B Q9WV60 mouse Tau 17762 P10637 Mapt mouse S696 449082 PVVsGDtsPRHLsNV X 35834; 20194; 98523; 91600; 49562 +Gsk3b GSK3B Q9WV60 mouse LPCAT1 210992 Q3TFD2 Lpcat1 mouse S182 17533101 VSRsDQDsRRKTVEE Acyltransferase X +Gsk3b GSK3B Q9WV60 mouse Jun 16476 P05627 Jun mouse T242 450450 VPEMPGEtPPLsPID Jun X +Gsk3b GSK3B Q9WV60 mouse SOX11 20666 Q7M6Y2 Sox11 mouse S289 50800237 PPAPPALsPASSRCV X +Gsk3b GSK3B Q9WV60 mouse axin 1 12005 O35625 Axin1 mouse T480 451091 HVQRVMRtPGCQsPG Axin_b-cat_bind X X +Gsk3b GSK3B Q9WV60 mouse Jun 16476 P05627 Jun mouse S246 450451 PGEtPPLsPIDMESQ X 2994 +Gsk3b GSK3B Q9WV60 mouse CARM1 59035 Q9WVG6 Carm1 mouse T132 125971700 LKTCRGHtLERSVFS CARM1 X +Gsk3b GSK3B Q9WV60 mouse RCAN1 54720 Q9JHG6 Rcan1 mouse S161 456022 PDKQFLIsPPAsPPV Calcipressin X +Gsk3b GSK3B Q9WV60 mouse Myc 17869 P01108 Myc mouse T73 448496 KKFELLPtPPLsPsR Myc_N X 46650 +Gsk3b GSK3B Q9WV60 mouse CCND3 12445 P30282 Ccnd3 mouse T283 452160 QGPSQTStPTDVTAI X X 53966 +Gsk3b GSK3B Q9WV60 mouse CRY2 12953 Q9R194 Cry2 mouse S557 456803 ALSsGPAsPKRKLEA X +Gsk3b GSK3B Q9WV60 mouse NFkB-p105 4790 P19838 NFKB1 human S907 451565 QAHsLPLsPAstRQQ X X +Gsk3b GSK3B Q9WV60 mouse Tau 17762 P10637 Mapt mouse S554 447930 NVRSkIGstENLKHQ Tubulin-binding X +Gsk3b GSK3B Q9WV60 mouse CTNNB1 12387 Q02248 Ctnnb1 mouse T120 6406005 QFDAAHPtNVQRLAE X +Gsk3b GSK3B Q9WV60 mouse CTNNB1 12387 Q02248 Ctnnb1 mouse T41 447583 GIHsGATtTAPsLsG X 9561; 9565; 4270; 13537; 41334; 60180 +Gsk3b GSK3B Q9WV60 mouse Tau 17762 P10637 Mapt mouse S688 449081 GAEIVyKsPVVsGDt X 9632 +Gsk3b GSK3B Q9WV60 mouse Kv4.2 16508 Q9Z0V2 Kcnd2 mouse S616 457613 EGDDRPEsPEYsGGN X +Gsk3b GSK3B Q9WV60 mouse NRF2 18024 Q60795 Nfe2l2 mouse S351 18258500 SRAsPEHsVESsIYG X X +Gsk3b GSK3B Q9WV60 mouse IL1RL1 17082 P14719 Il1rl1 mouse S442 25585004 AATVVESsIQNsRRQ TIR X +Gsk3b GSK3B Q9WV60 mouse gephyrin 268566 Q8BUV3 Gphn mouse S270 2020113 LsttPsEsPRAQATs X +Gsk3b GSK3B Q9WV60 mouse axin 1 12005 O35625 Axin1 mouse S485 451092 MRtPGCQsPGPGHRs Axin_b-cat_bind X X +Gsk3b GSK3B Q9WV60 mouse CRMP-2 12934 O08553 Dpysl2 mouse T509 448083 PVCEVsVtPktVtPA X +Gsk3b GSK3B Q9WV60 mouse SIRT7 209011 Q8BKJ9 Sirt7 mouse S260 1874512904 EAAtEAAsKADtILC SIR2 X +Gsk3b GSK3B Q9WV60 mouse CTNNB1 12387 Q02248 Ctnnb1 mouse S33 447487 QQQsYLDsGIHsGAT X X 9561; 2009; 4270; 13537; 41334; 60180 +Tyk2 Tyk2 Q9R117 mouse IL13R 16164 O09030 Il13ra1 mouse Y402 450931 HWKKYDIyEKQSKEE X X +MAPK1 ERK2 Q8UWG6 chicken CRY2 12953 Q9R194 Cry2 mouse S265 453402 NANSLLAsPTGLSPY X X +MAPK1 ERK2 Q8UWG6 chicken CRY1 12952 P97784 Cry1 mouse S247 453401 NANSLLAsPtGLSPY X X +MAPK1 ERK2 Q8UWG6 chicken IRX2 373975 Q9PU52 IRX2 chicken S65 452192 AAATGFTsPLQYSTD X +MAPK1 ERK2 Q8UWG6 chicken IRX2 373975 Q9PU52 IRX2 chicken S46 452191 SSSGSAFsPYPGSAA X +MAPKAPK2 MAPKAPK2 P49137 human TAB3 257397 Q8N5C8 TAB3 human S506 1295507 HKYQRsSsSGSDDyA X +MAPKAPK2 MAPKAPK2 P49137 human Vimentin 280955 P48616 VIM cow T51 449416 LRPTTSRtLYTSsPG Filament_head X +MAPKAPK2 MAPKAPK2 P49137 human SMAD2 Q1W668 SMAD2 cow S255 448796 ELsPTTLsPVNHSLD X +MAPKAPK2 MAPKAPK2 P49137 human CDC25B 994 P30305 CDC25B human S169 455885 VLRNItNsQAPDGRR M-inducer_phosp X +MAPKAPK2 MAPKAPK2 P49137 human RSK2 110651 P18654 Rps6ka3 mouse S227 448063 DHEKKAysFCGtVEy Pkinase X 3556 +MAPKAPK2 MAPKAPK2 P49137 human Oct4 5460 Q01860 POU5F1 human S93 25236708 PQGGLEtsQPEGEAG X +MAPKAPK2 MAPKAPK2 P49137 human hnRNP A0 10949 Q13151 HNRNPA0 human S84 449874 VELkRAVsREDsARP X +MAPKAPK2 MAPKAPK2 P49137 human HSP27 15507 P14602 Hspb1 mouse S86 448403 RALNRQLssGVsEIR X 2406; 2401; 9709; 11892; 64293 +MAPKAPK2 MAPKAPK2 P49137 human GJA1 2697 P17302 GJA1 human S255 448852 HAtsGALsPAkDCGs X +MAPKAPK2 MAPKAPK2 P49137 human HSP27 3315 P04792 HSPB1 human S78 448402 PAysRALsRQLssGV X X 2405 +MAPKAPK2 MAPKAPK2 P49137 human LIMK1 3984 P53667 LIMK1 human S323 459630 KDLGrSEsLRVVCRP X X +MAPKAPK2 MAPKAPK2 P49137 human WNK4 65266 Q96J92 WNK4 human S575 53332700 PFLFRHAsYSSTTSD X +MAPKAPK2 MAPKAPK2 P49137 human CREB 1385 P16220 CREB1 human S119 448228 EILsRRPsyRkILND pKID X X 9187; 9196; 9198; 4095; 14228; 14001; 39561; 80120; 44864; 54960; 95995 +MAPKAPK2 MAPKAPK2 P49137 human CapZIP 92241 Q6JBY9 RCSD1 human S179 456201 RRFRRsQsDCGELGD CAP-ZIP_m X +MAPKAPK2 MAPKAPK2 P49137 human RBM7 67010 Q9CQT2 Rbm7 mouse S136 453069 QMVQRSFssPEDYQR X +MAPKAPK2 MAPKAPK2 P49137 human MKL1 57591 Q969V6 MRTFA human S333 3208578 CGLARQNstsLtGKP X X +MAPKAPK2 MAPKAPK2 P49137 human 14-3-3 zeta 7534 P63104 YWHAZ human S58 449833 VVGARRssWRVVssI 14-3-3 X 52631 +MAPKAPK2 MAPKAPK2 P49137 human TTP 22695 P22893 Zfp36 mouse S52 451150 RLTGRSTsLVEGRsC X +MAPKAPK2 MAPKAPK2 P49137 human TFCP2L1 81879 Q3UNW5 Tfcp2l1 mouse S393 1875342302 LPQKQDDsGDNsLCV X +MAPKAPK2 MAPKAPK2 P49137 human AGO2 27161 Q9UKV8 AGO2 human S387 472450 SkLMRsAsFNtDPyV ArgoL2 X X +MAPKAPK2 MAPKAPK2 P49137 human mGluR5 108071 Q3UVX5 Grm5 mouse S1158 25581600 LVALtPPsPFRDSVD GluR_Homer-bdg X +MAPKAPK2 MAPKAPK2 P49137 human BAG2 9532 O95816 BAG2 human S20 452167 GRFCRSSsMADRSSR X X +MAPKAPK2 MAPKAPK2 P49137 human Oct4 5460 Q01860 POU5F1 human S111 25236703 EsNsDGAsPEPCtVt X X +MAPKAPK2 MAPKAPK2 P49137 human Vimentin 280955 P48616 VIM cow S56 451514 SRtLYTSsPGGVYAT Filament_head X +MAPKAPK2 MAPKAPK2 P49137 human MDM2 4193 Q00987 MDM2 human S157 455457 SHLVSRPstSsRRRA X +MAPKAPK2 MAPKAPK2 P49137 human RBM7 10179 Q9Y580 RBM7 human S204 4033285 QrkVrMNsyPYLADr X X +MAPKAPK2 MAPKAPK2 P49137 human RIPK1 19766 Q60855 Ripk1 mouse S336 209632700 LPPsRsNsEQPGSLH X +MAPKAPK2 MAPKAPK2 P49137 human MDM2 4193 Q00987 MDM2 human S166 448130 SsRRRAIsEtEENsD X 3521 +MAPKAPK2 MAPKAPK2 P49137 human EEF2K 29904 O00418 EEF2K human S377 450811 PPLLRPLsENsGDEN X +MAPKAPK2 MAPKAPK2 P49137 human TTP 22695 P22893 Zfp36 mouse S178 451151 HVLRQsIsFsGLPsG X +MAPKAPK2 MAPKAPK2 P49137 human TH iso4 7054 P07101-4 TH human S44 448545 RFIGRRQsLIEDARK TOH_N X 2791 +MAPKAPK2 MAPKAPK2 P49137 human K18 3875 P05783 KRT18 human S53 447734 IsVsrstsFrGGMGs X +MAPKAPK2 MAPKAPK2 P49137 human RDBP 7936 P18615 NELFE human S51 454289 GGVkRsLsEQPVMDt X +MAPKAPK2 MAPKAPK2 P49137 human RBM7 10179 Q9Y580 RBM7 human S136 453069 QIIQRsFssPENFQr X X +MAPKAPK2 MAPKAPK2 P49137 human MAPKAPK2 9261 P49137 MAPKAPK2 human T338 448274 VPQtPLHtsRVLKED X +MAPKAPK2 MAPKAPK2 P49137 human MKL1 223701 Q8K4J6 Mrtfa mouse S371 3208578 SGLARQssTALAAKP X +MAPKAPK2 MAPKAPK2 P49137 human BRF1 677 Q07352 ZFP36L1 human S92 470147 RFRDRsFsEGGERLL Tis11B_N X X +MAPKAPK2 MAPKAPK2 P49137 human Nogo iso2 57142 Q9NQC3-2 RTN4 human S107 457468 VAPERQPsWDPSPVS X X +MAPKAPK2 MAPKAPK2 P49137 human PLK1 5347 P53350 PLK1 human S326 5393500 LTIPPRFsIAPssLD X X +MAPKAPK2 MAPKAPK2 P49137 human CEP131 22994 Q9UPN4 CEP131 human S47 3216078 kPIVRsVsVVTGsEQ X +MAPKAPK2 MAPKAPK2 P49137 human CapZIP 92241 Q6JBY9 RCSD1 human S244 456202 PPLRRsPsRTEKQEE RCSD X +MAPKAPK2 MAPKAPK2 P49137 human K20 66809 Q9D312 Krt20 mouse S13 463823 QSFHRsLsSSsQGPA X +MAPKAPK2 MAPKAPK2 P49137 human Akt1 207 P31749 AKT1 human S473 447855 RPHFPQFsysAsGtA Pkinase_C X 9271; 3787; 4060; 4051; 5102; 4058; 2336; 2337; 4075; 4070; 5012; 4071; 92982; 5315; 9563; 9018; 12694; 52240; 11962; 15116; 88106; 26580; 68035; 31957; 23430; 20235 +MAPKAPK2 MAPKAPK2 P49137 human ARPC5 10092 O15511 ARPC5 human S77 3309801 AVKDrAGsIVLKVLI P16-Arc X +MAPKAPK2 MAPKAPK2 P49137 human HSP27 15507 P14602 Hspb1 mouse S15 448401 FsLLrsPsWEPFRDW X +MAPKAPK2 MAPKAPK2 P49137 human p53 7157 P04637 TP53 human S20 447529 PLsQEtFsDLWkLLP P53_TAD X 9287 +MAPKAPK2 MAPKAPK2 P49137 human TRIM29 23650 Q14134 TRIM29 human S550 31836501 GyPsLMRsQsPkAQP X +MAPKAPK2 MAPKAPK2 P49137 human HSPA1L 3305 P34931 HSPA1L human S241 1869383201 DFDNRLVsHFVEEFK HSP70 X +MAPKAPK2 MAPKAPK2 P49137 human RSK2 6197 P51812 RPS6KA3 human S386 448065 HQLFRGFsFVAItsD Pkinase_C X X 9341; 9335; 13575; 11989; 12032; 75266; 93317; 13397; 13588 +MAPKAPK2 MAPKAPK2 P49137 human CDC25B 994 P30305 CDC25B human S323 448409 QRLFRsPsMPCsVIR M-inducer_phosp X +MAPKAPK2 MAPKAPK2 P49137 human BRF1 677 Q07352 ZFP36L1 human S203 470146 PRLQHsFsFAGFPSA X X +MAPKAPK2 MAPKAPK2 P49137 human TH iso3 7054 P07101-3 TH human S19 448542 KGFRRAVsELDAKQA TOH_N X +MAPKAPK2 MAPKAPK2 P49137 human PLK1 5347 P53350 PLK1 human S383 5393501 DMLQQLHsVNAskPS X +MAPKAPK2 MAPKAPK2 P49137 human TFCP2L1 81879 Q3UNW5 Tfcp2l1 mouse S397 1875342304 QDDsGDNsLCVyHAI X +MAPKAPK2 MAPKAPK2 P49137 human Vimentin 280955 P48616 VIM cow S83 451816 GVRLLQDsVDFSLAD Filament_head X +MAPKAPK2 MAPKAPK2 P49137 human PARN 5073 O95453 PARN human S557 483559 NHyYRNNsFTAPsTV X X +MAPKAPK2 MAPKAPK2 P49137 human PDE4A 25638 P54748 Pde4a rat S147 3189445 sFLYRSDsDYDMsPK X X +MAPKAPK2 MAPKAPK2 P49137 human MKL1 223701 Q8K4J6 Mrtfa mouse S351 10989194 PTPSRsLstsSsPsS X +MAPKAPK2 MAPKAPK2 P49137 human DDX5 1655 P17844 DDX5 human S198 27807802 CRACRLkstCIyGGA DEAD X X +MAPKAPK2 MAPKAPK2 P49137 human TH iso2 7054 P07101-2 TH human S19 448542 KGFRRAVsELDAKQA TOH_N X +MAPKAPK2 MAPKAPK2 P49137 human TH iso2 7054 P07101-2 TH human S67 448545 RFIGRRQsLIEDARK TOH_N X 2791 +MAPKAPK2 MAPKAPK2 P49137 human p90RSK 6195 Q15418 RPS6KA1 human S380 447990 HQLFRGFsFVAtGLM Pkinase_C X X 9341; 9335; 13575; 11989; 12032; 75266; 93317; 13397; 13588 +MAPKAPK2 MAPKAPK2 P49137 human GJA1 2697 P17302 GJA1 human S279 448853 sSPtAPLsPMsPPGy X +MAPKAPK2 MAPKAPK2 P49137 human CEP131 22994 Q9UPN4 CEP131 human S78 1211822 NNLRRsNsttQVSQP X +MAPKAPK2 MAPKAPK2 P49137 human DAZL 1618 Q92904 DAZL human S65 31908003 SFFARYGsVkEVKII RRM_1 X +MAPKAPK2 MAPKAPK2 P49137 human RIPK1 8737 Q13546 RIPK1 human S320 468644 AVVkRMQsLQLdCVA X X 58274; 39341 +MAPKAPK2 MAPKAPK2 P49137 human AYTL1 270084 Q8BYI6 Lpcat2 mouse S34 15146101 PMVPRQAsFFPPPVP X +MAPKAPK2 MAPKAPK2 P49137 human BRF1 677 Q07352 ZFP36L1 human S54 2475300 GGFPRRHsVtLPSSk Tis11B_N X X +MAPKAPK2 MAPKAPK2 P49137 human RDBP 7936 P18615 NELFE human S251 468611 GPFRRsDsFPERRAP X +MAPKAPK2 MAPKAPK2 P49137 human COPS5 10987 Q92905 COPS5 human S177 1874115102 IDPTRTIsAGkVNLG X X +MAPKAPK2 MAPKAPK2 P49137 human HIF3A iso2 53417 Q0VBL6-2 Hif3a mouse S184 291887100 HFSLRMKsTLtSRGR X +MAPKAPK2 MAPKAPK2 P49137 human TH iso4 7054 P07101-4 TH human S19 448542 KGFRRAVsELDAKQA TOH_N X +MAPKAPK2 MAPKAPK2 P49137 human SRF 6722 P11831 SRF human S103 447692 RGLKRsLsEMEIGMV X X 4261 +MAPKAPK2 MAPKAPK2 P49137 human TIF1B 10155 Q13263 TRIM28 human S473 452391 sGVkRsRsGEGEVsG X X +MAPKAPK2 MAPKAPK2 P49137 human GJA1 2697 P17302 GJA1 human S282 448854 tAPLsPMsPPGykLV X +MAPKAPK2 MAPKAPK2 P49137 human TH 7054 P07101 TH human S71 448545 RFIGRRQsLIEDARK TOH_N X 2791 +MAPKAPK2 MAPKAPK2 P49137 human RDBP 7936 P18615 NELFE human S115 452641 QPFQRsIsADDDLQE X +MAPKAPK2 MAPKAPK2 P49137 human CREB iso1 81646 P15337-1 Creb1 rat S133 448228 EILsRRPsYRkILND pKID X 9187; 9196; 9198; 4095; 14228; 14001; 39561; 80120; 44864; 54960; 95995 +MAPKAPK2 MAPKAPK2 P49137 human LSP1 16985 P19973 Lsp1 mouse S195 4704192 KLADRTEsLNRsIKK Caldesmon X +MAPKAPK2 MAPKAPK2 P49137 human LSP1 4046 P33241 LSP1 human S252 479435 PKLARQAsIELPsMA Caldesmon X +MAPKAPK2 MAPKAPK2 P49137 human PDE4D iso6 5144 Q08499-6 PDE4D human S133 483644 sFLYRSDsDYDLSPk X +MAPKAPK2 MAPKAPK2 P49137 human PIAS1 8554 O75925 PIAS1 human S522 3177709 DTSYINTsLIQDYRH X X +MAPKAPK2 MAPKAPK2 P49137 human TH iso3 7054 P07101-3 TH human S404 10348000 GELLHCLsEEPEIRA Biopterin_H X +MAPKAPK2 MAPKAPK2 P49137 human 5-LO 240 P09917 ALOX5 human S272 450169 CsLERQLsLEQEVQQ Lipoxygenase X 3748 +MAPKAPK2 MAPKAPK2 P49137 human MKL1 57591 Q969V6 MRTFA human S312 10989194 tPPVRsLstTNSsSS X X +MAPKAPK2 MAPKAPK2 P49137 human SMAD2 Q1W668 SMAD2 cow S250 448795 TGsPAELsPTTLsPV X +MAPKAPK2 MAPKAPK2 P49137 human AATF 26574 Q9NY61 AATF human T366 27136800 FTVYRNRtLQkWHDK AATF-Che1 X X +MAPKAPK2 MAPKAPK2 P49137 human HSP27 3315 P04792 HSPB1 human S15 448401 FsLLrGPsWDPFrDW X X 2404 +MAPKAPK2 MAPKAPK2 P49137 human CDC25B 994 P30305 CDC25B human S375 455380 ARVLRsksLCHDEIE M-inducer_phosp X +MAPKAPK2 MAPKAPK2 P49137 human TRIM29 23650 Q14134 TRIM29 human S552 27457998 PsLMRsQsPkAQPQT X +MAPKAPK2 MAPKAPK2 P49137 human HSF1 3297 Q00613 HSF1 human S121 455480 NIkRkVtsVSTLksE X +MAPKAPK2 MAPKAPK2 P49137 human Bcl-xL 598 Q07817 BCL2L1 human S62 449099 PSWHLADsPAVNGAT X +MAPKAPK2 MAPKAPK2 P49137 human PFKFB3 5209 Q16875 PFKFB3 human S461 448801 NPLMRRNsVtPLAsP X X +MAPKAPK2 MAPKAPK2 P49137 human TSC2 7249 P49815 TSC2 human S1254 448807 TALyksLsVPAASTA X X 3616 +MAPKAPK2 MAPKAPK2 P49137 human PDE4D iso6 24627 P14270-6 Pde4d rat S67 483644 SFLYRSDsDYDLSPK X +MAPKAPK2 MAPKAPK2 P49137 human TH 7054 P07101 TH human S19 448542 KGFRRAVsELDAKQA TOH_N X +MAPKAPK2 MAPKAPK2 P49137 human LSP1 16985 P19973 Lsp1 mouse S243 479435 PKLsRQPsIELPsMA Caldesmon X +MAPKAPK2 MAPKAPK2 P49137 human RSK2 110651 P18654 Rps6ka3 mouse S386 448065 HQLFRGFsFVAITSD Pkinase_C X 9341; 9335; 13575; 11989; 12032; 75266; 93317; 13397; 13588 +MAPKAPK2 MAPKAPK2 P49137 human CDC25C 995 P30307 CDC25C human S216 448418 sGLyRsPsMPENLNR M-inducer_phosp X 9528; 4901; 30790 +MAPKAPK2 MAPKAPK2 P49137 human Vimentin 280955 P48616 VIM cow S39 451766 TTSTRTYsLGSALRP Filament_head X +MAPKAPK2 MAPKAPK2 P49137 human p47phox 17969 Q09014 Ncf1 mouse S329 449404 QDtYRRNsVRFLQQR NECFESHC X X +MAPKAPK2 MAPKAPK2 P49137 human CREB 12912 Q01147 Creb1 mouse S119 448228 EILsRRPsyRkILND pKID X 9187; 9196; 9198; 4095; 14228; 14001; 39561; 80120; 44864; 54960; 95995 +MAPKAPK2 MAPKAPK2 P49137 human TH iso3 7054 P07101-3 TH human S40 448545 RFIGRRQsLIEDARK TOH_N X 2791 +MAPKAPK2 MAPKAPK2 P49137 human beclin 1 8678 Q14457 BECN1 human S90 472001 IPPARMMstEsANsF X X 29362; 86455 +MAPKAPK2 MAPKAPK2 P49137 human K20 54474 P35900 KRT20 human S13 463823 RSFHRsLsSSLQAPV X 39359 +MAPKAPK2 MAPKAPK2 P49137 human HSP27 3315 P04792 HSPB1 human S82 448403 RALsRQLssGVsEIr X X 2406; 2401; 9709; 11892; 64293 +MAPKAPK2 MAPKAPK2 P49137 human RIPK1 19766 Q60855 Ripk1 mouse S321 468644 PVLQRMFsLQHDCVP X X 83613; 38662 +MAPKAPK2 MAPKAPK2 P49137 human CDC25B 994 P30305 CDC25B human S353 452008 VQNkRRRsVtPPEEQ M-inducer_phosp X +Grk6 GRK6 O70293 mouse KOR-1 18387 P33534 Oprk1 mouse S369 449609 NtVQDPAsMRDVGGM X +Grk6 GRK6 O70293 mouse KOR-1 18387 P33534 Oprk1 mouse T357 52467201 MRMERQstNRVRNtV X +Grk6 GRK6 O70293 mouse KOR-1 18387 P33534 Oprk1 mouse S356 52467200 KMRMERQstNRVRNt X +Grk6 GRK6 O70293 mouse CXCR4 7852 P61073 CXCR4 human S339 458320 GkrGGHssVstEsEs X 59028 +Grk6 GRK6 O70293 mouse CXCR4 7852 P61073 CXCR4 human S330 12575202 GssLkILskGkrGGH X +Grk6 GRK6 O70293 mouse KOR-1 18387 P33534 Oprk1 mouse T363 52467202 stNRVRNtVQDPAsM X +Map3k1 MEKK1 Q62925 rat MEK1 26395 P31938 Map2k1 mouse T292 448287 EtPPRPRtPGRPLsS Pkinase X 26975 +MARK3 MARK3 iso3 P27448-3 human MARK3 iso3 4140 P27448-3 MARK3 human S601 470100 SQTRsRGstNLFsKL X +MARK3 MARK3 iso3 P27448-3 human MARK3 iso3 4140 P27448-3 MARK3 human S598 3597302 TPLSQTRsRGstNLF X +MARK3 MARK3 iso3 P27448-3 human MARK3 iso3 4140 P27448-3 MARK3 human S606 3597306 RGstNLFsKLTSKLT X +MARK3 MARK3 iso3 P27448-3 human MARK3 iso3 4140 P27448-3 MARK3 human T602 3597301 QTRsRGstNLFsKLT X +CSNK1G2 CK1G2 P78368 human COL4A3BP 10087 Q9Y5P4 CERT1 human S132 483985 ssLRRHGsMVsLVsG X X +CSNK1G2 CK1G2 P78368 human SNCA 6622 P37840 SNCA human T64 1876998407 EktkEQVtNVGGAVV Synuclein X +CSNK1G2 CK1G2 P78368 human beclin 1 8678 Q14457 BECN1 human S409 41159603 kIEDtGGsGGSYSIK APG6 X X +CSNK1G2 CK1G2 P78368 human SNCA 20617 O55042 Snca mouse T64 1876998407 EKtKEQVtNVGGAVV Synuclein X +CSNK1G2 CK1G2 P78368 human SMAD3 4088 P84022 SMAD3 human S418 6845003 LtQMGsPsIRCssVs X X +CSNK1G2 CK1G2 P78368 human LYN 4067 P07948 LYN human S13 1983291 SKGkDsLsDDGVDLk X +CSNK1G2 CK1G2 P78368 human beclin 1 8678 Q14457 BECN1 human T406 41159604 EKGkIEDtGGsGGSY APG6 X +CSNK1G2 CK1G2 P78368 human IRS4 8471 O14654 IRS4 human S859 36276295 KDAAsKPsGEGsFsK X X +Akt2 Akt2 Q60823 mouse GAB2 14389 Q9Z1S8 Gab2 mouse T388 448383 ATIPRRNtLPAMDNS X +Akt2 Akt2 Q60823 mouse QIK 235344 Q8CFH6 Sik2 mouse S358 487501 DGRQRRPstIAEQTV X +Akt2 Akt2 Q60823 mouse SGTA 6449 O43765 SGTA human S305 479908 QIRsRtPsAsNDDQQ X 8664 +Akt2 Akt2 Q60823 mouse SOX9 20682 Q04887 Sox9 mouse S181 456981 YQPrrrKsVKNGQAE X X +Akt2 Akt2 Q60823 mouse PGC-1 alpha 19017 O70343 Ppargc1a mouse S570 2045307 RMRSRsRsFsRHRSC X +Akt2 Akt2 Q60823 mouse STXBP4 20913 Q9WV89 Stxbp4 mouse S99 455472 RAKLRSEsPWEIAFI X X +Akt2 Akt2 Q60823 mouse MYO5A 17918 Q99104 Myo5a mouse S1650 480053 GLRKRtssIADEGty X +Akt2 Akt2 Q60823 mouse PITX2 18741 P97474 Pitx2 mouse T90 25790902 KRQRRQRtHFTSQQL Homeodomain X +Akt2 Akt2 Q60823 mouse GAB2 14389 Q9Z1S8 Gab2 mouse S211 4825112 TENARSAsFSQGTRQ X +PRKCQ PKCT Q04759 human HEXIM1 10614 O94992 HEXIM1 human S158 25680402 KKHRRRPsKKKRHWk X X +PRKCQ PKCT Q04759 human Radixin 5962 P35241 RDX human T564 448374 AGRDKyKtLRQIRQG ERM_C X 3141; 3726; 32600 +PRKCQ PKCT Q04759 human CARD11 416476 Q5F3W0 RCJMB04_5k17 chicken S668 457639 LERPFRPsVTSVGRI X 5189 +PRKCQ PKCT Q04759 human LLGL1 3996 Q15334 LLGL1 human S663 449917 LkKsLRQsFRRIRKs X +PRKCQ PKCT Q04759 human PDK1 5170 O15530 PDPK1 human S241 447693 skQARANsFVGtAQy Pkinase X 3061; 3438 +PRKCQ PKCT Q04759 human CARD11 84433 Q9BXL7 CARD11 human S893 1876333500 sPRLSRAsFLFGQLL X X +PRKCQ PKCT Q04759 human BAD 572 Q92934 BAD human S75 447860 EIRsRHssyPAGtED Bcl-2_BAD X 9291; 5284; 9296; 5193; 11865; 94223 +PRKCQ PKCT Q04759 human LLGL1 3996 Q15334 LLGL1 human S673 449918 RIRKsRVsGKKRAAN X +PRKCQ PKCT Q04759 human NKD2 85409 Q969F2 NKD2 human S31 23254812 FVASAYAsGRKGAEE X +PRKCQ PKCT Q04759 human Ezrin 7430 P15311 EZR human T567 448104 QGRDkyKtLRQIRQG ERM_C X 3141; 3726; 32600 +PRKCQ PKCT Q04759 human CACNA1C 100101555 P15381 CACB rabbit S1928 455278 ASLGRRAsFHLECLK CAC1F_C X +PRKCQ PKCT Q04759 human PDK1 5170 O15530 PDPK1 human S64 27457101 EPRPGAGsLQHAQPP X +PRKCQ PKCT Q04759 human PDK1 18607 Q9Z2A0 Pdpk1 mouse S532 5938009 TYYLMDPsGNAHKWC PH_3 X +PRKCQ PKCT Q04759 human PKCT 5588 Q04759 PRKCQ human T219 457380 SAINSREtMFHkERF X +PRKCQ PKCT Q04759 human IRS1 3667 P35568 IRS1 human S1101 453434 GCRRRHssEtFsStP X +PRKCQ PKCT Q04759 human RANGAP1 5905 P46060 RANGAP1 human S504 1873645604 LMQKAFNsssFNSNT RanGAP1_C X +PRKCQ PKCT Q04759 human HePTP 5778 P35236 PTPN7 human S246 460715 QYQEERRsVkHILFS Y_phosphatase X +PRKCQ PKCT Q04759 human CARD11 108723 Q8CIS0 Card11 mouse S564 457637 QPHRSRSsIMsItAE X +PRKCQ PKCT Q04759 human girdin 55704 Q3V6T2 CCDC88A human S1690 27811900 LQQFLEEsNKLTSVQ X X +PRKCQ PKCT Q04759 human HPCAL1 3241 P37235 HPCAL1 human T149 1876861206 EStPEKRtDKIFRQM EF-hand_7 X +PRKCQ PKCT Q04759 human RASGRP1 10125 O95267 RASGRP1 human T184 456226 RDWSRKLtQRIKSNT X +PRKCQ PKCT Q04759 human SHP-1 15170 P29351 Ptpn6 mouse S591 454019 DKEKNKGsLKRK___ X +PRKCQ PKCT Q04759 human CARD11 84433 Q9BXL7 CARD11 human S559 457637 QPPRsRssIMsITAE X +PRKCQ PKCT Q04759 human EAR-2 2063 P10588 NR2F6 human S83 25802106 CKSFFKRsIRRNLsY zf-C4 X +PRKCQ PKCT Q04759 human CACNA1C 100101555 P15381 CACB rabbit S528 486358 ARLAHRIsKSKFsRY X +PRKCQ PKCT Q04759 human LLGL1 3996 Q15334 LLGL1 human S655 449915 GPLSRVKsLkKsLRQ X +PRKCQ PKCT Q04759 human CD4 12504 P06332 Cd4 mouse S432 451188 QRQAARMsQIKRLLS Tcell_CD4_C X +PRKCQ PKCT Q04759 human H3 8350 P68431 H3C1 human S10 455676 tkQtArkstGGkAPr Histone X 9701; 9711; 9606; 3465; 3642; 3377; 3475; 3458; 5764; 47398; 8481; 8552; 53348; 29237; 66065; 43185; 64522; 52725 +PRKCQ PKCT Q04759 human AID 11628 Q9WVE0 Aicda mouse S3 20660600 _____MDsLLMKQKK X +PRKCQ PKCT Q04759 human CACNA1C 100101555 P15381 CACB rabbit S533 453091 RIsKSKFsRYWRRWN X +PRKCQ PKCT Q04759 human LLGL1 3996 Q15334 LLGL1 human S659 449916 RVKsLkKsLRQsFRR X +PRKCQ PKCT Q04759 human KRas iso2 3845 P01116-2 KRAS human S181 459210 GKKKKkKskTkCVIM X +PRKCQ PKCT Q04759 human SHP-1 5777 P29350 PTPN6 human S591 454019 DKEKsKGsLKRK___ X +PRKCQ PKCT Q04759 human LLGL1 3996 Q15334 LLGL1 human S670 10405473 sFRRIRKsRVsGKKR X +PRKCQ PKCT Q04759 human FRA1 8061 P15407 FOSL1 human S265 478352 PSSDPLGsPtLLAL_ X 3880; 5841 +PRKCQ PKCT Q04759 human Moesin 4478 P26038 MSN human T558 447706 LGRDKyKtLRQIRQG ERM_C X 3141; 3726; 32600 +PRKCQ PKCT Q04759 human IRS1 16367 P35569 Irs1 mouse S318 451399 MVGGKPGsFRVRASs X 5610 +PRKCQ PKCT Q04759 human WIPF1 7456 O43516 WIPF1 human S488 449880 RNESRSGsNRRErGA X +PRKCQ PKCT Q04759 human RAPGEF2 9693 Q9Y4G8 RAPGEF2 human S960 1245534 KKRVRRssFLNAKKL X X +PRKCQ PKCT Q04759 human PIP5K1B 18719 P70181 Pip5k1b mouse S413 27461455 PSKKRCNsIAALKAT X +PRKCQ PKCT Q04759 human Cbl-b 868 Q13191 CBLB human S282 25802103 KysTKPGsYIFRLSC Cbl_N3 X +PRKCQ PKCT Q04759 human HABP4 22927 Q5JVS0 HABP4 human T375 11380903 GRGARGGtRGGRGRI IHABP4_N X +PRKCQ PKCT Q04759 human STLK3 27347 Q9UEW8 STK39 human S323 450932 LCLQkDPskRPTAAE Pkinase X +PRKCQ PKCT Q04759 human PDK1 18607 Q9Z2A0 Pdpk1 mouse S504 5938008 LKGEIPWsQELRPEA PH_3 X +PRKCQ PKCT Q04759 human HePTP 5778 P35236 PTPN7 human S44 448309 RLQERrGsNVALMLD X +PRKCQ PKCT Q04759 human ICAM3 3385 P32942 ICAM3 human S518 451020 REHQRsGsyHVREEs X +PRKCQ PKCT Q04759 human FRA1 8061 P15407 FOSL1 human T230 27259000 tPSLtPFtPSLVFTY X +PRKCQ PKCT Q04759 human CARD11 108723 Q8CIS0 Card11 mouse S657 457639 LERPFRPsVTSGGHV X 5189 +PRKCQ PKCT Q04759 human FRA1 8061 P15407 FOSL1 human T223 1270901 HtPTLMTtPSLtPFt X +PRKCQ PKCT Q04759 human mGluR5 24418 P31424 Grm5 rat S839 455778 VRSAFTTstVVRMHV X +PRKCQ PKCT Q04759 human CARD11 108723 Q8CIS0 Card11 mouse S649 457638 NLMLRKFsLERPFRP X +PRKCQ PKCT Q04759 human HABP4 22927 Q5JVS0 HABP4 human T354 11380902 RKPANDItSQLEINF IHABP4_N X +PRKCQ PKCT Q04759 human CACNA1C 100101555 P15381 CACB rabbit S1674 480102 QGLVGKPsQRNALSL X +PRKCQ PKCT Q04759 human BAD 572 Q92934 BAD human S99 447862 PFrGrsRsAPPNLWA Bcl-2_BAD X 9295; 5286; 4366 +PRKCQ PKCT Q04759 human MYPT1 4659 O14974 PPP1R12A human T853 452075 PREKRRstGVsFWtQ X 4563 +PRKCQ PKCT Q04759 human RANGAP1 5905 P46060 RANGAP1 human S506 1873645606 QKAFNsssFNSNTFL RanGAP1_C X +PRKCQ PKCT Q04759 human ARHGEF6 9459 Q15052 ARHGEF6 human S225 456738 KSSERPLsPkAVkGF X X +PRKCQ PKCT Q04759 human TBK1 29110 Q9UHD2 TBK1 human S716 4271179 HILERFGsLTMDGGL X X +PRKCQ PKCT Q04759 human ARHGEF6 9459 Q15052 ARHGEF6 human S488 452424 LSASPRMsGFIyQGk PH X X +PRKCQ PKCT Q04759 human STLK3 27347 Q9UEW8 STK39 human S309 450930 MMKKyGKsFRkLLSL Pkinase X +PRKCQ PKCT Q04759 human RASGRP3 25780 Q8IV61 RASGRP3 human T133 454419 YDWMRRVtQRKKVSK X X +Fgr FGR Q6P6U0 rat SDHA Q920L2 Sdha rat Y596 1458603 YkVRIDEyDYSkPIE Succ_DH_flav_C X +Fgr FGR Q6P6U0 rat SDHA Q920L2 Sdha rat Y535 1458604 CEkVSQLyGDLQHLk Succ_DH_flav_C X +Fgr FGR Q6P6U0 rat FGR 79113 Q6P6U0 Fgr rat Y511 448121 FTSTEPQyQPGDQT_ X +Fgr FGR Q6P6U0 rat CK2A1 1457 P68400 CSNK2A1 human Y255 450324 VLGTEDLyDyIDkYN Pkinase X +Fgr FGR Q6P6U0 rat FGR 79113 Q6P6U0 Fgr rat Y400 448120 RLIVDDEyNPQQGTK PK_Tyr_Ser-Thr X +Fgr FGR Q6P6U0 rat ACO2 79250 Q9ER34 Aco2 rat Y544 1458607 FDPGQDTyQHPPkDS X +Fgr FGR Q6P6U0 rat HS1 3059 P14317 HCLS1 human Y222 452057 MEAPttAykkTTPIE X +Fgr FGR Q6P6U0 rat ACO2 79250 Q9ER34 Aco2 rat Y665 1458606 VVIGDENyGEGsSRE Aconitase_C X +Fgr FGR Q6P6U0 rat ACO2 79250 Q9ER34 Aco2 rat Y71 1458605 TLSEkIVyGHLDDPA Aconitase X +PRKACB PKACB P22694 human PKACB 18749 P68181 Prkacb mouse T198 452130 RVKGRtWtLCGtPEY Pkinase X 4781; 5661 +PRKACB PKACB P22694 human AQP2 359 P41181 AQP2 human S256 449854 REVRRRQsVELHsPQ X +PRKACB PKACB P22694 human SFRS2 6427 Q01130 SRSF2 human S121 6422897 GyGrRSRsPRRRRRs X +PRKACB PKACB P22694 human SFRS2 6427 Q01130 SRSF2 human S171 29431801 RSARRsKsksSsVsR X +PRKACB PKACB P22694 human SFRS2 6427 Q01130 SRSF2 human S128 29431802 sPRRRRRsRsRSRSR X +PRKACB PKACB P22694 human NGFR 4804 P08138 NGFR human S303 10432300 PEGEKLHsDsGIsVD X X +PRKACB PKACB P22694 human SFRS2 6427 Q01130 SRSF2 human S130 29431800 RRRRRsRsRSRSRSR X +CSNK1G1 CK1G1 Q9HCP0 human SNCA 6622 P37840 SNCA human T64 1876998407 EktkEQVtNVGGAVV Synuclein X +CSNK1G1 CK1G1 Q9HCP0 human APC 324 P25054 APC human S1507 452097 FsCsssLsALsLDEP APC_r X +CSNK1G1 CK1G1 Q9HCP0 human LRP6 4040 O75581 LRP6 human T1479 457635 SSsstKGtyFPAILN X X +CSNK1G1 CK1G1 Q9HCP0 human SNCA 20617 O55042 Snca mouse T64 1876998407 EKtKEQVtNVGGAVV Synuclein X +CSNK1G1 CK1G1 Q9HCP0 human APC 324 P25054 APC human S1505 452096 DGFsCsssLsALsLD APC_r X +CSNK1G1 CK1G1 Q9HCP0 human NFkB-p65 5970 Q04206 RELA human S536 447800 sGDEDFSsIADMDFS X X 4887; 3036; 3031; 4886; 3033; 4025; 5733; 13346; 76778; 31553; 80477; 73992; 87672; 83962 +CSNK1G1 CK1G1 Q9HCP0 human LYN 4067 P07948 LYN human S13 1983291 SKGkDsLsDDGVDLk X +CSNK1G1 CK1G1 Q9HCP0 human APC 324 P25054 APC human S1510 999606 sssLsALsLDEPFIQ X +CSNK1G1 CK1G1 Q9HCP0 human APC 324 P25054 APC human S1504 999604 PDGFsCsssLsALsL APC_r X +Csnk1e CK1E Q9JMK2 mouse LPIN1 14245 Q91ZP3 Lpin1 mouse S483 471356 VGGsGIDsGVEsTSD X +Csnk1e CK1E Q9JMK2 mouse PER2 18627 O54943 Per2 mouse S659 449331 TLPGKAEsVVsLTSQ X X +Csnk1e CK1E Q9JMK2 mouse PER1 18626 O35973 Per1 mouse S661 451683 SSSYTASsAsDDDKQ X X +Csnk1e CK1E Q9JMK2 mouse DARPP-32 19049 Q60829 Ppp1r1b mouse S130 448046 EEDEEEDsQAEVLKG DARPP-32 X +Csnk1e CK1E Q9JMK2 mouse PER1 18626 O35973 Per1 mouse S663 451684 SYTASsAsDDDKQRA X X +Csnk1e CK1E Q9JMK2 mouse LPIN1 14245 Q91ZP3 Lpin1 mouse S487 62856003 GIDsGVEsTSDSLRD X +Csnk1e CK1E Q9JMK2 mouse DNMT1 13433 P13864 Dnmt1 mouse S146 4702934 ksDsDtLsVEtsPss X +Stk11 LKB1 Q9WTK7 mouse AMPKA1 65248 P54645 Prkaa1 rat T269 450433 VDPMKRAtIKDIREH Pkinase X +Stk11 LKB1 Q9WTK7 mouse AMPKA1 105787 Q5EG47 Prkaa1 mouse S172 15407586 KIADFGLsNMMsDGE Pkinase X +Stk11 LKB1 Q9WTK7 mouse AMPKA2 78975 Q09137 Prkaa2 rat T258 450434 VDPLKRAtIKDIREH Pkinase X +Stk11 LKB1 Q9WTK7 mouse AMPKA1 65248 P54645 Prkaa1 rat T183 448786 SDGEFLRtsCGSPNY Pkinase X 2535; 2531; 4188; 5256; 50081; 74281 +Stk11 LKB1 Q9WTK7 mouse LKB1 20869 Q9WTK7 Stk11 mouse T336 448150 KDRWRSMtVVPYLED X X +Stk11 LKB1 Q9WTK7 mouse AMPKA2 78975 Q09137 Prkaa2 rat S491 450432 StPQRSCsAAGLHRP AdenylateSensor X 4185 +Stk11 LKB1 Q9WTK7 mouse AMPKA1 105787 Q5EG47 Prkaa1 mouse T183 448786 sDGEFLRtsCGsPNY Pkinase X 2535; 2531; 4188; 5256; 50081; 74281 +Stk11 LKB1 Q9WTK7 mouse PAK1 5058 Q13153 PAK1 human T109 14150103 QWARLLQtsNITKsE PBD X +Stk11 LKB1 Q9WTK7 mouse AMPKA1 5562 Q13131 PRKAA1 human T183 448786 sDGEFLRtsCGsPNy Pkinase X 2535; 2531; 4188; 5256; 50081; 74281 +Stk11 LKB1 Q9WTK7 mouse PAK1 18479 O88643 Pak1 mouse T109 14150103 QWARLLQtSNITKsE PBD X +Stk11 LKB1 Q9WTK7 mouse AMPKA1 65248 P54645 Prkaa1 rat S496 450431 AtPQRSGsISNYRSC AdenylateSensor X 4185; 4184; 2537 +Stk11 LKB1 Q9WTK7 mouse LKB1 20869 Q9WTK7 Stk11 mouse T366 448151 IEDGIIytQDFTVPG X X +Stk11 LKB1 Q9WTK7 mouse AMPKA2 78975 Q09137 Prkaa2 rat T172 448026 SDGEFLRtsCGSPNY Pkinase X 2535; 2531; 5256; 50081; 74281 +MAP2K5 MEK5 Q13163 human ERK5 5598 Q13164 MAPK7 human Y221 448206 HQyFMtEyVAtRWYR Pkinase X X +MAP2K5 MEK5 Q13163 human ERK5 5598 Q13164 MAPK7 human T219 448205 AEHQyFMtEyVAtRW Pkinase X X 3371 +Insr INSR P15127 rat INSR 24954 P15127 Insr rat Y1186 447680 FGMTRDIyEtDyyRK PK_Tyr_Ser-Thr X 3021; 80732 +Insr INSR P15127 rat caveolin-2 363425 Q2IBC5 Cav2 rat Y27 454430 sHHSVVDyTDPEKYV Caveolin X X +Insr INSR P15127 rat INSR 24954 P15127 Insr rat Y1362 447684 TyDEHIPyTHMNGGK X +Insr INSR P15127 rat INSR 24954 P15127 Insr rat Y1190 447681 RDIyEtDyyRKGGKG PK_Tyr_Ser-Thr X 3024; 3918; 2969 +Insr INSR P15127 rat caveolin-2 363425 Q2IBC5 Cav2 rat Y19 450198 LFMADDAysHHSVVD Caveolin X X +Insr INSR P15127 rat CBL 867 P22681 CBL human Y700 448529 EGEEDtEyMtPssRP X 8869 +Insr INSR P15127 rat IRS1 25467 P35570 Irs1 rat Y895 447556 EPKsPGEyVNIEFGS X X 3070 +Insr INSR P15127 rat IRS1 25467 P35570 Irs1 rat Y460 451286 GEEELSNyICMGGKG X X +Insr INSR P15127 rat IRS1 25467 P35570 Irs1 rat Y608 447555 NLHtDDGyMPMsPGV X X +Insr INSR P15127 rat IRS1 25467 P35570 Irs1 rat Y1172 451288 GLEKSLNyIDLDLVK X X +Insr INSR P15127 rat CBL 867 P22681 CBL human Y371 449753 TQEQyELyCEMGSTF X +Insr INSR P15127 rat IRS1 25467 P35570 Irs1 rat Y628 447565 NRKGNGDyMPMsPKs X X +Insr INSR P15127 rat CBL 867 P22681 CBL human Y774 448531 sENEDDGyDVPKPPV X 3555 +Insr INSR P15127 rat INSR 24954 P15127 Insr rat Y1191 447682 DIyEtDyyRKGGKGL PK_Tyr_Ser-Thr X 3024; 2969 +Insr INSR P15127 rat IRS1 25467 P35570 Irs1 rat Y1222 448699 ssEDLSTyASINFQK X X 3066 +Insr INSR P15127 rat IRS1 25467 P35570 Irs1 rat Y987 451287 VPNSRGDyMTMQIGC X X +Insr INSR P15127 rat IRS1 25467 P35570 Irs1 rat Y939 448700 EETGSEEyMNMDLGP X X +Insr INSR P15127 rat APS 114203 Q9Z200 Sh2b2 rat Y618 448842 ARAVENQySFY____ X +Insr INSR P15127 rat INSR 24954 P15127 Insr rat Y1356 447683 SLsIKRTyDEHIPyT X +Insr INSR P15127 rat ANXA1 25380 P07150 Anxa1 rat Y21 447974 IEkQEQEyVQAVKSY X +Ephb1 EphB1 Q8CBF3 mouse NCAM-L1 16728 P11627 L1cam mouse Y1232 10272401 DGsFIGQySGKKEKE Bravo_FIGEY X +Rps6ka1 p90RSK Q63531 rat Fos 314322 P12841 Fos rat S362 448481 AAAHRKGsSSNEPSS X +Rps6ka1 p90RSK Q63531 rat BSN 29138 O88778 Bsn rat S2845 456576 KTLQRSLsDPKPLSP X +Rps6ka1 p90RSK Q63531 rat ETV1 2115 P50549 ETV1 human S216 3059600 PMYQRQMsEPNIPFP ETS_PEA3_N X X +Rps6ka1 p90RSK Q63531 rat nNOS 24598 P29476 Nos1 rat S847 447886 SYKVRFNsVSSYSDS Flavodoxin_1 X X +Rps6ka1 p90RSK Q63531 rat p27Kip1 1027 P46527 CDKN1B human T198 448781 PGLRRRQt_______ X X +Rps6ka1 p90RSK Q63531 rat ETV1 2115 P50549 ETV1 human S191 3059602 HRFRRQLsEPCNSFP ETS_PEA3_N X X +Rps6ka1 p90RSK Q63531 rat IkB-alpha 25493 Q63746 Nfkbia rat S32 448203 LVDDRHDsGLDsMKD X 5210; 2859; 9246; 5209 +Rps6ka1 p90RSK Q63531 rat ETV1 2115 P50549 ETV1 human S334 3059601 PTYQRRGsLQLWQFL X +Rps6ka1 p90RSK Q63531 rat p27Kip1 1027 P46527 CDKN1B human S10 447874 NVRVSNGsPsLErMD X +Rps6ka1 p90RSK Q63531 rat IkB-beta 81525 Q9JIA3 Nfkbib rat S23 447916 WCDsGLGsLGPDAAA X X +Rps6ka1 p90RSK Q63531 rat CREB iso1 81646 P15337-1 Creb1 rat S133 448228 EILsRRPsYRkILND pKID X 9187; 9196; 9198; 4095; 14228; 14001; 39561; 80120; 44864; 54960; 95995 +Rps6ka1 p90RSK Q63531 rat NCAM-L1 50687 Q05695 L1cam rat S1154 449315 RSKGGKysVKDKEDT Bravo_FIGEY X +Rps6ka1 p90RSK Q63531 rat NHE1 24782 P26431 Slc9a1 rat S707 448347 MsRARIGsDPLAYEP X +Rps6ka1 p90RSK Q63531 rat C/EBP-beta 24253 P21272 Cebpb rat S105 448425 AKPSKKPsDYGyVsL X 3081 +Rps6ka1 p90RSK Q63531 rat BSN 12217 O88737 Bsn mouse S2860 456576 KTLQRsLsDPKPLsP X +Rps6ka1 p90RSK Q63531 rat IkB-alpha 25493 Q63746 Nfkbia rat S36 448204 RHDsGLDsMKDEDyE X 5210; 9246 +Rps6ka1 p90RSK Q63531 rat IkB-beta 81525 Q9JIA3 Nfkbib rat S19 447917 DADEWCDsGLGsLGP X X +Lats1 LATS1 Q8BYR2 mouse YAP1 22601 P46938 Yap1 mouse S112 448847 PQHVRAHssPAsLQL X X 4911; 13008; 92367; 57706 +Lats1 LATS1 Q8BYR2 mouse AMOT 27494 Q8VHG2 Amot mouse S176 28699604 QGHVRSLsERLMQMs X +Lats1 LATS1 Q8BYR2 mouse TAZ 97064 Q9EPK5 Wwtr1 mouse S89 457660 AQHVRSHssPAsLQL X 75275; 59971 +LTK LTK P29376 human PREB 10113 Q9HCU5 PREB human Y10 1868624703 RRRAPELyRAPFPLY X +MINK1 MINK Q8N4C8 human SMAD1 4086 Q15797 SMAD1 human T322 25802105 sNVNRNStIENTRRH MH2 X X +MINK1 MINK Q8N4C8 human GR 2908 P04150 NR3C1 human T562 1872513501 StWRIMTtLNMLGGR Hormone_recep X +MINK1 MINK Q8N4C8 human SMAD2 17126 Q62432 Smad2 mouse T324 23146436 SNVNRNAtVEMTRRH MH2 X +MINK1 MINK Q8N4C8 human GR 2908 P04150 NR3C1 human T635 1872513505 IINEQRMtLPCMYDQ Hormone_recep X +MINK1 MINK Q8N4C8 human GR 2908 P04150 NR3C1 human T524 1872513504 NKtIVPAtLPQLTPT X +MINK1 MINK Q8N4C8 human LATS1 9113 O95835 LATS1 human T1079 457595 EHAFyEFtFRRFFDD X 8654 +CHEK1 Chk1 O14757 human Src 6714 P12931 SRC human S51 2420700 AdGHRGPsAAFAPAA X X +CHEK1 Chk1 O14757 human SH2BP1 9646 Q6PD62 CTR9 human S1081 10399992 RRPRRQRsDQDsDsD X +CHEK1 Chk1 O14757 human LAMC1 3915 P11047 LAMC1 human T258 28846246 VTLNRLNtFGDEVFN Laminin_N X +CHEK1 Chk1 O14757 human DDX19A 55308 Q9NUU7 DDX19A human S92 27447122 sPLYSVksFEELRLK X +CHEK1 Chk1 O14757 human hnRNP A2/B1 3181 P22626 HNRNPA2B1 human T159 10154941 krGFGFVtFDDHDPV RRM_1 X +CHEK1 Chk1 O14757 human RPL19 6143 P84098 RPL19 human T56 14579426 LIIRkPVtVHsRARC Ribosomal_L19e X +CHEK1 Chk1 O14757 human YB-1 4904 P67809 YBX1 human T80 9412957 GFINRNDtkEDVFVH CSD X +CHEK1 Chk1 O14757 human TICRR 90381 Q7Z2Z1 TICRR human T1898 38520202 RPIsRTYtRKKLMGT X +CHEK1 Chk1 O14757 human BAZ1A 11177 Q9NRL2 BAZ1A human S1320 28846202 RSLRkINsAPPtETk X +CHEK1 Chk1 O14757 human BLM 641 P54132 BLM human S539 10852147 DQNkHtAsINDLERE BDHCT_assoc X +CHEK1 Chk1 O14757 human H3 360198 P68433 H3c1 mouse T11 455680 kQTARkstGGkAPrk Histone X 9767; 9764 +CHEK1 Chk1 O14757 human NFkB-p105 18033 P25799 Nfkb1 mouse S240 34354490 VSDAIyDsKAPNAsN RHD_DNA_bind X +CHEK1 Chk1 O14757 human E2F3 1871 O00716 E2F3 human S124 11929101 PALGrGGsGGGGGPP X X +CHEK1 Chk1 O14757 human Chk1 1111 O14757 CHEK1 human S296 447832 GFskHIQsNLDFsPV X X 2349; 90178 +CHEK1 Chk1 O14757 human TRIP12 9320 Q14669 TRIP12 human S1078 15723449 SGLARAAskDTISNN X +CHEK1 Chk1 O14757 human TLK1 9874 Q9UKI8 TLK1 human S743 449050 PHMRRsNssGNLHMA X X +CHEK1 Chk1 O14757 human CLK3 1198 P49761 CLK3 human S157 2192633 HHCKRyRsPEPDPyL X +CHEK1 Chk1 O14757 human EPRS 2058 P07814 EPRS1 human S910 18910291 VLFDkVAsQGEVVRK WHEP-TRS X +CHEK1 Chk1 O14757 human SETMAR 6419 Q53H47 SETMAR human S508 10940417 LYDNRRRsAQWLDQE Transposase_1 X X +CHEK1 Chk1 O14757 human CK1D 64462 Q06486 Csnk1d rat S328 3190837 PATRGLPstAsGRLR X X +CHEK1 Chk1 O14757 human PROTOR1 55615 P85299 PRR5 human S240 3892597 RLLRRsRsGDVLAkN X +CHEK1 Chk1 O14757 human E2F6 1876 O75461 E2F6 human S52 29609300 EDNVQyVsMRKALKV X +CHEK1 Chk1 O14757 human p53 7157 P04637 TP53 human S37 447532 NVLsPLPsQAMDDLM TAD2 X X 9289 +CHEK1 Chk1 O14757 human p73 7161 O15350 TP73 human S47 452197 EVVGGTDssMDVFHL X X +CHEK1 Chk1 O14757 human GTF3C1 2975 Q12789 GTF3C1 human S667 12260181 VRLVRNLsEEGLLRL X +CHEK1 Chk1 O14757 human p21Cip1 12575 P39689 Cdkn1a mouse T140 447837 QGRKRRQtsLTDFYH X X +CHEK1 Chk1 O14757 human RBM26 64062 Q5T8P6 RBM26 human T839 28846284 TELRRkytELQLEAA X +CHEK1 Chk1 O14757 human p57Kip2 12577 P49919 Cdkn1c mouse S19 22354700 TAMERLAssDTFPVI X X +CHEK1 Chk1 O14757 human CSDA 8531 P16989 YBX3 human T112 9412967 GFINRNDtkEDVFVH CSD X +CHEK1 Chk1 O14757 human INF2 64423 Q27J81 INF2 human S574 28846237 LNWQkLPsNVAREHN FH2 X +CHEK1 Chk1 O14757 human TICRR 90381 Q7Z2Z1 TICRR human S1045 10989971 RsVQRVHsFQQDKsD X +CHEK1 Chk1 O14757 human Chk1 1111 O14757 CHEK1 human T382 1388511400 KRMtRFFtkLDADks X X +CHEK1 Chk1 O14757 human Src 6714 P12931 SRC human Y530 448235 FTstEPQyQPGENL_ X 2105 +CHEK1 Chk1 O14757 human CDC25A 993 P30304 CDC25A human S76 449340 SNLQRMGssEstDsG X X +CHEK1 Chk1 O14757 human CK1D 64462 Q06486 Csnk1d rat S370 483997 MERERKVsMRLHRGA X X +CHEK1 Chk1 O14757 human CK1D 64462 Q06486 Csnk1d rat S331 2192627 RGLPstAsGRLRGTQ X X +CHEK1 Chk1 O14757 human KI-67 4288 P46013 MKI67 human T1764 3148167 RsLRkADtEEEFLAF KI67R X +CHEK1 Chk1 O14757 human TFDP1 7027 Q14186 TFDP1 human S23 3196109 VFIDQNLsPGkGVVS X +CHEK1 Chk1 O14757 human MIG-6 54206 Q9UJM3 ERRFI1 human S302 468194 KPDYRRWsAEVTSST X X +CHEK1 Chk1 O14757 human FANCD2 2177 Q9BXW9 FANCD2 human S331 11315004 KSKGRASsSGNQESS FancD2 X X +CHEK1 Chk1 O14757 human RALY 22913 Q9UKM9 RALY human T160 27455306 PLVrRVktNVPVkLF X +CHEK1 Chk1 O14757 human 53BP1 7158 Q12888 TP53BP1 human S1678 476255 ItsEEERsPAKRGRK X +CHEK1 Chk1 O14757 human ZNF638 27332 Q14966 ZNF638 human S375 28846314 GsKkNYQsQADIPIr X +CHEK1 Chk1 O14757 human SFRS2IP 9169 Q99590 SCAF11 human S1127 3210312 QQsYkRksEQEFsFD X +CHEK1 Chk1 O14757 human SRm300 23524 Q9UQ35 SRRM2 human S2280 28846295 PrTAVAPsAVNLADP X +CHEK1 Chk1 O14757 human NFkB-p65 5970 Q04206 RELA human T505 455490 EAITRLVtGAQRPPD X X +CHEK1 Chk1 O14757 human CHD-7 55636 Q9P2D1 CHD7 human T1227 28846215 AILEKNFtFLSKGGG SNF2-rel_dom X +CHEK1 Chk1 O14757 human GOLGA4 2803 Q13439 GOLGA4 human S71 452809 KLQLRVPsVEsLFRs X +CHEK1 Chk1 O14757 human ADD3 120 Q9UEY8 ADD3 human S693 452158 KKKFRtPsFLKKNKK X +CHEK1 Chk1 O14757 human KIFC1 3833 Q9BW19 KIFC1 human S26 477789 RPLIkAPsQLPLsGs X +CHEK1 Chk1 O14757 human SEPT7 989 Q16181 SEPTIN7 human T228 471456 kIyEFPEtDDEEENk Septin X +CHEK1 Chk1 O14757 human matrin 3 9782 P43243 MATR3 human S195 476155 sFDDrGPsLNPVLDy X +CHEK1 Chk1 O14757 human CDC25A 993 P30304 CDC25A human S124 449127 PALkRSHsDsLDHDI M-inducer_phosp X X +CHEK1 Chk1 O14757 human SCML2 10389 Q9UQR0 SCML2 human S570 478158 MYIHtsVsQDFSRsV X +CHEK1 Chk1 O14757 human SRm300 23524 Q9UQ35 SRRM2 human T2252 28846299 ArtPAIPtAVNLADS X +CHEK1 Chk1 O14757 human MCM5 4174 P33992 MCM5 human T633 28846249 MkLQPFAtEADVEEA MCM_lid X +CHEK1 Chk1 O14757 human SHARP 23013 Q96T58 SPEN human T1059 3640035 IKLDRLNtVAsPKDC X +CHEK1 Chk1 O14757 human LATS2 26524 Q9NRM7 LATS2 human S835 28706304 GSHVRQDsMEPSDLW Pkinase X X +CHEK1 Chk1 O14757 human RAD51 5888 Q06609 RAD51 human T309 455229 LRKGRGEtRICKIyD Rad51 X X +CHEK1 Chk1 O14757 human RIF1 55183 Q5UIP0 RIF1 human S2205 3201699 VNkVRRVsFADPIyQ X +CHEK1 Chk1 O14757 human AurB 9212 Q96GD4 AURKB human S331 22259700 HPWVRANsRRVLPPS X X +CHEK1 Chk1 O14757 human E2F7 52679 Q6S7F2 E2f7 mouse S411 3208641 ERLVRyGsFNTVHTS X X +CHEK1 Chk1 O14757 human CCDC49 54883 Q9NXE8 CWC25 human S337 3214029 PGYTRKLsAEELERK X +CHEK1 Chk1 O14757 human RBM14 10432 Q96PK6 RBM14 human S627 4756664 sQLsFRRsPtKssLD X +CHEK1 Chk1 O14757 human IDI1 3422 Q13907 IDI1 human S55 28846234 GLLHRAFsVFLFNTE NUDIX X +CHEK1 Chk1 O14757 human Chk1 1111 O14757 CHEK1 human T378 1388511401 QRLVKRMtRFFtkLD X X +CHEK1 Chk1 O14757 human CAAP1 79886 Q9H8G2 CAAP1 human S203 2906731 EGDNGMDsDMEEEAD X +CHEK1 Chk1 O14757 human TLK1 9874 Q9UKI8 TLK1 human S679 15406524 KPFGHNQsQQDILQE Pkinase X +CHEK1 Chk1 O14757 human PRRC2C 23215 Q9Y520 PRRC2C human S661 28846200 QPRPAVLsGyFkQFQ X +CHEK1 Chk1 O14757 human TICRR 90381 Q7Z2Z1 TICRR human S865 9764262 NALIRHksIAEVSQN Treslin_N X +CHEK1 Chk1 O14757 human RASSF1 iso2 11186 Q9NS23-2 RASSF1 human T38 30259806 ALRIARGtACNPtRQ X +CHEK1 Chk1 O14757 human PHF2 5253 O75151 PHF2 human S929 28846276 REGtRVAsIETGLAA X +CHEK1 Chk1 O14757 human SNCB 6620 Q16143 SNCB human Y127 22461200 EDPPQEEyQEYEPEA X X +CHEK1 Chk1 O14757 human EXO1 9156 Q9UQ84 EXO1 human S746 1240803 PGLYkSSsADsLStT X X +CHEK1 Chk1 O14757 human PLK1 5347 P53350 PLK1 human T210 448139 YDGERKktLCGtPNy Pkinase X X 4354; 5472; 9062 +CHEK1 Chk1 O14757 human hnRNP M 4670 P52272 HNRNPM human S432 467999 HGMDrVGsEIERMGL X +CHEK1 Chk1 O14757 human MED1 5469 Q15648 MED1 human T704 28846253 PEKPKHQtEDDFQRE X +CHEK1 Chk1 O14757 human CCDC6 8030 Q16204 CCDC6 human S244 450707 QPVsAPPsPRDIsME DUF2046 X +CHEK1 Chk1 O14757 human p53 7157 P04637 TP53 human T387 455224 HkkLMFktEGPDsD_ X X +CHEK1 Chk1 O14757 human TICRR 90381 Q7Z2Z1 TICRR human S1115 7990154 KsHQKsLsFskttPR X +CHEK1 Chk1 O14757 human YBX2 51087 Q9Y2T7 YBX2 human T115 9412983 GFINRNDtkEDVFVH CSD X +CHEK1 Chk1 O14757 human WIZ 58525 O95785 WIZ human S1129 483171 sLEARsPsDLHIsPL X +CHEK1 Chk1 O14757 human NIPA 51530 Q86WB0 ZC3HC1 human T84 28848800 AFFSRVEtFSsLkWA zf-C3HC X +CHEK1 Chk1 O14757 human Hck 3055 P08631 HCK human Y411 448168 RVIEDNEytAREGAk PK_Tyr_Ser-Thr X 2101; 6943; 59548; 70926; 78740; 94361; 17320 +CHEK1 Chk1 O14757 human p53 7157 P04637 TP53 human T18 447541 EPPLsQEtFsDLWkL P53_TAD X 2529 +CHEK1 Chk1 O14757 human ASF1A 25842 Q9Y294 ASF1A human S166 3245981 kLEDAEssNPNLQsL X X +CHEK1 Chk1 O14757 human CDC25A 993 P30304 CDC25A human S178 449126 LFTQRQNsAPARMLs M-inducer_phosp X X +CHEK1 Chk1 O14757 human RASSF1 iso2 11186 Q9NS23-2 RASSF1 human T43 30259807 RGtACNPtRQLVPGR X +CHEK1 Chk1 O14757 human NUP153 9972 P49790 NUP153 human S297 28846270 QMkAkQLsAQSyGVT Nup153 X +CHEK1 Chk1 O14757 human CK1D 64462 Q06486 Csnk1d rat T397 3362909 QDtsRMstsQIPGRV X X +CHEK1 Chk1 O14757 human E2F8 108961 Q58FA4 E2f8 mouse S395 10994497 PSFTRHPsLIKLVKS X X +CHEK1 Chk1 O14757 human p53 7157 P04637 TP53 human S20 447529 PLsQEtFsDLWkLLP P53_TAD X X 9287 +CHEK1 Chk1 O14757 human LATS2 26524 Q9NRM7 LATS2 human S408 17600400 PVPSRTNsFNSHQPR X +CHEK1 Chk1 O14757 human NFkB-p105 18033 P25799 Nfkb1 mouse S326 22771100 VNITKPAsVFVQLRR RHD_dimer X +CHEK1 Chk1 O14757 human MDM4 17248 O35618 Mdm4 mouse S367 457676 PDCRRtIsAPVVRPK X +CHEK1 Chk1 O14757 human SLTM 79811 Q9NWH9 SLTM human S748 7447222 WsENKkLsLDtDARF X +CHEK1 Chk1 O14757 human OGT 8473 O15294 OGT human S20 3174941 EPTkRMLsFQGLAEL X X +CHEK1 Chk1 O14757 human H3 360198 P68433 H3c1 mouse S10 455676 tkQTARkstGGkAPr Histone X 9701; 9711; 9606; 3465; 3642; 3377; 3475; 3458; 5764; 47398; 8481; 8552; 53348; 29237; 66065; 43185; 64522; 52725 +CHEK1 Chk1 O14757 human NEK11 79858 Q8NG66 NEK11 human S273 10433801 SMLNKNPsLRPSAIE Pkinase X X +CHEK1 Chk1 O14757 human RBM28 55131 Q9NW13 RBM28 human S122 3245387 RLIIRNLsFKCSEDD RRM_1 X +CHEK1 Chk1 O14757 human Tau iso8 4137 P10636-8 MAPT human S262 447930 NVKskIGstENLkHQ Tubulin-binding X +CHEK1 Chk1 O14757 human BLM 641 P54132 BLM human T182 41290000 sHFVRVStAQKSKKG BLM_N X X +CHEK1 Chk1 O14757 human SSBP1 6742 Q04837 SSBP1 human S67 4774304 ATNEMWRsGDsEVyQ SSB X +CHEK1 Chk1 O14757 human MDC1 9656 Q14676 MDC1 human T523 481891 sTtVDINtQVEKEVP X +CHEK1 Chk1 O14757 human KPNA2 3838 P52292 KPNA2 human S54 10941719 MLkRRNVssFPDDAt IBB X +CHEK1 Chk1 O14757 human MCM3 4172 P25205 MCM3 human S160 2201400 KtIERRysDLttLVA MCM_OB X +CHEK1 Chk1 O14757 human SRm300 23524 Q9UQ35 SRRM2 human S1499 453299 tPRPRsRsPssPELN X +CHEK1 Chk1 O14757 human Chk1 1111 O14757 CHEK1 human S316 12084535 EENVkYsssQPEPRT X +CHEK1 Chk1 O14757 human POP4 10775 O95707 POP4 human S10 460860 SVIyHALsQkEANDs X +CHEK1 Chk1 O14757 human ADD2 119 P35612 ADD2 human S713 449802 KKKFRtPsFLKKsKK X +CHEK1 Chk1 O14757 human RAVER1 iso2 125950 Q8IY67-2 RAVER1 human S700 15422762 PLGGQkRsFAHLLPs X +CHEK1 Chk1 O14757 human ADD1 118 P35611 ADD1 human S726 449829 KKKFRtPsFLKKsKK X +CHEK1 Chk1 O14757 human ANKRD12 iso2 23253 Q6UB98-2 ANKRD12 human S76 28846100 SRNEERDsDTEKEGP X +CHEK1 Chk1 O14757 human MIG-6 54206 Q9UJM3 ERRFI1 human S251 3215403 RRLRRsHsGPAGsFN X X +CHEK1 Chk1 O14757 human ZNF395 55893 Q9H8N7 ZNF395 human S447 4943578 LSPVRSRsLsFSEPQ X +CHEK1 Chk1 O14757 human Ku70 2547 P12956 XRCC6 human S477 3180585 RFTYrsDsFENPVLQ Ku_C X +CHEK1 Chk1 O14757 human MAD2L1 4085 Q13257 MAD2L1 human S185 4326275 sEEVRLRsFtTTIHk HORMA X +CHEK1 Chk1 O14757 human MST1 6789 Q13043 STK4 human T340 3801524 AVGDEMGtVRVASTM X +CHEK1 Chk1 O14757 human MYCBP2 23077 O75592 MYCBP2 human S3478 467339 TVFQRsYsVVASEYD X +CHEK1 Chk1 O14757 human RPL19 6143 P84098 RPL19 human S12 4272220 rLQKrLAssVLRCGK Ribosomal_L19e X +CHEK1 Chk1 O14757 human BUD13 84811 Q9BRD0 BUD13 human S18 4763637 EYLKRYLsGADAGVD X +CHEK1 Chk1 O14757 human AS160 9882 O60343 TBC1D4 human S588 455920 RMRGRLGsVDsFERs X 8730 +CHEK1 Chk1 O14757 human MEK2 5605 P36507 MAP2K2 human T59 28846262 KRLEAFLtQkAkVGE X +CHEK1 Chk1 O14757 human FAM122A 116224 Q96E09 PABIR1 human S37 3208890 GGLRRsNsAPLIHGL X +CHEK1 Chk1 O14757 human p53 7157 P04637 TP53 human S378 447534 skkGQstsRHkkLMF X +CHEK1 Chk1 O14757 human MAD2L1 4085 Q13257 MAD2L1 human T187 22640014 EVRLRsFtTTIHkVN HORMA X +CHEK1 Chk1 O14757 human E2F6 1876 O75461 E2F6 human S12 27532759 RPARkLPsLLLDPTE X +CHEK1 Chk1 O14757 human CCDC6 8030 Q16204 CCDC6 human S240 452441 EkLDQPVsAPPsPRD DUF2046 X +CHEK1 Chk1 O14757 human DDX24 57062 Q9GZR7 DDX24 human S82 452946 KRKAQAVsEEEEEEE X +CHEK1 Chk1 O14757 human MAP4 4134 P27816 MAP4 human T521 452281 MALGKDVtPPPEtEV X +CHEK1 Chk1 O14757 human Cortactin 2017 Q14247 CTTN human S298 5014901 EKLAkHEsQQDyskG HS1_rep X +CHEK1 Chk1 O14757 human RBM42 79171 Q9BTD8 RBM42 human S406 28846288 RAFSRFPsFLKAKVI RRM_1 X +CHEK1 Chk1 O14757 human RBM14 10432 Q96PK6 RBM14 human S618 468597 LsDyrRLsEsQLsFR X +CHEK1 Chk1 O14757 human FEN1 2237 P39748 FEN1 human T195 15426136 PVLMrHLtAsEAkkL XPG_I X +CHEK1 Chk1 O14757 human EBNA1BP2 10969 Q99848 EBNA1BP2 human T182 28846219 kYGKkVQtEVLQkRQ Ebp2 X +CHEK1 Chk1 O14757 human TIF1B 10155 Q13263 TRIM28 human S473 452391 sGVkRsRsGEGEVsG X +CHEK1 Chk1 O14757 human Chk1 1111 O14757 CHEK1 human S291 10991667 sEsPsGFskHIQsNL X +CHEK1 Chk1 O14757 human RANBP2 5903 P49792 RANBP2 human T1098 15422730 QTIGPrNtFNFGsKN X +CHEK1 Chk1 O14757 human matrin 3 9782 P43243 MATR3 human T150 1218501 LQLkRRRtEEGPtLs X +CHEK1 Chk1 O14757 human MYBBP1A 10514 Q9BQG0 MYBBP1A human S1310 483421 sLVIRsPsLLQsGAk X +CHEK1 Chk1 O14757 human SENP2 59343 Q9HC62 SENP2 human S344 3868126 GLLRRKVsIIEtKEK X +CHEK1 Chk1 O14757 human BLM 641 P54132 BLM human S646 15349300 LKHERFQsLSFPHTk BDHCT_assoc X X +CHEK1 Chk1 O14757 human CAMSAP1L1 23271 Q08AD1 CAMSAP2 human S464 2020305 RGITRsIsNEGLtLN X +CHEK1 Chk1 O14757 human CHTOP 26097 Q9Y3Y2 CHTOP human T212 28846206 ALArPVLtkEQLDNQ FoP_duplication X +CHEK1 Chk1 O14757 human CDC25B 994 P30305 CDC25B human S563 470116 tFRLKTRsWAGERSR X +CHEK1 Chk1 O14757 human HPV16 protein E6 1489078 P03126 E6 papillomavirus T156 1884110701 SSRTRREtQL_____ X +CHEK1 Chk1 O14757 human BAT2L 84726 Q5JSZ5 PRRC2B human S166 483694 RGSSrLLsFsPEEFP BAT2_N X +CHEK1 Chk1 O14757 human RBM14 10432 Q96PK6 RBM14 human T629 456092 LsFRRsPtKssLDyR X +CHEK1 Chk1 O14757 human lamin A/C 4000 P02545 LMNA human S307 5450481 DsLsAQLsQLQkQLA Filament X +CHEK1 Chk1 O14757 human H3 8350 P68431 H3C1 human T11 455680 kQtArkstGGkAPrk Histone X 9767; 9764 +CHEK1 Chk1 O14757 human MDM4 4194 O15151 MDM4 human S342 470031 SkLTHSLsTSDITAI X +CHEK1 Chk1 O14757 human ZBTB11 27107 O95625 ZBTB11 human S537 28846310 KRKAVPKsAVQQVAQ X +CHEK1 Chk1 O14757 human PHF8 23133 Q9UPP1 PHF8 human S904 17556614 REGtRVAsIEtGLAA X +CHEK1 Chk1 O14757 human MgcRacGAP 29127 Q9H0H5 RACGAP1 human S203 459866 GPVkKTRsIGsAVDQ X +CHEK1 Chk1 O14757 human DDX19B 11269 Q9UMR2 DDX19B human S93 27447125 sPLYSVksFEELRLK X +CHEK1 Chk1 O14757 human TLK2 11011 Q86UE8 TLK2 human S686 15406527 KPFGHNQsQQDILQE Pkinase X +CHEK1 Chk1 O14757 human ARHGEF2 9181 Q92974 ARHGEF2 human S172 460815 LGLRRILsQstDsLN X +CHEK1 Chk1 O14757 human PPME1 51400 Q9Y570 PPME1 human S15 476688 MHLGRLPsrPPLPGs X +CHEK1 Chk1 O14757 human H3F3A 3020 P84243 H3-3A human S31 18545303 AARksAPsTGGVkkP Histone X X +CHEK1 Chk1 O14757 human matrin 3 9782 P43243 MATR3 human S4 4761999 ____MsksFQQssLs X +CHEK1 Chk1 O14757 human MAP4 4134 P27816 MAP4 human T925 476126 PRLSRLAtNtsAPDL X +CHEK1 Chk1 O14757 human ING1 iso2 3621 Q9UK53-2 ING1 human S126 484008 LGDTAGNsGKAGADR X +CHEK1 Chk1 O14757 human PRPF3 9129 O43395 PRPF3 human S161 28846280 EERKkQLsFIsPPtP X +CHEK1 Chk1 O14757 human AS160 9882 O60343 TBC1D4 human S485 4755108 LVIQRHLssLtDNEQ X +CHEK1 Chk1 O14757 human p53 7157 P04637 TP53 human S15 447490 PsVEPPLsQEtFsDL P53_TAD X X 4030; 9235; 9284; 9286; 8695; 8514; 82530; 56979 +CHEK1 Chk1 O14757 human vigilin 3069 Q00341 HDLBP human T8 28846306 MSSVAVLtQEsFAEH X +CHEK1 Chk1 O14757 human PROSER2 254427 Q86WR7 PROSER2 human S43 480487 SSSSRsRsFtLDDEs X +CHEK1 Chk1 O14757 human CDK13 8621 Q14004 CDK13 human S437 451875 RsRsRHssIsPstLT X +CHEK1 Chk1 O14757 human NHS 4810 Q6T4R5 NHS human T401 3203073 RKLRRRKtIsGIPRR X +CHEK1 Chk1 O14757 human RRP12 23223 Q5JTH9 RRP12 human S1049 483802 AKRHRALsQAAVEEE X +CHEK1 Chk1 O14757 human claspin 63967 Q9HAW4 CLSPN human T916 455334 DELLDLCtGKFTsQA X X +CHEK1 Chk1 O14757 human PPP2R5D 5528 Q14738 PPP2R5D human S60 457388 PsSNKRPsNstPPPt X X +CHEK1 Chk1 O14757 human p21Cip1 12575 P39689 Cdkn1a mouse S141 447836 GRKRRQtsLTDFYHS X X +CHEK1 Chk1 O14757 human DRG2 1819 P55039 DRG2 human S72 23100718 VALIGFPsVGKSTFL MMR_HSR1 X +CHEK1 Chk1 O14757 human PLRG1 5356 O43660 PLRG1 human S119 9316251 TkIQRMPsEsAAQsL X +CHEK1 Chk1 O14757 human HIVEP1 3096 P15822 HIVEP1 human S1749 3180926 ASSKRMLsPANsLDI X +CHEK1 Chk1 O14757 human SRm300 23524 Q9UQ35 SRRM2 human S2388 15428491 tsPrVPLsAyErVsG X +CHEK1 Chk1 O14757 human RASSF1 iso2 11186 Q9NS23-2 RASSF1 human S184 7447198 PssKKPPsLQDARRG X X +CHEK1 Chk1 O14757 human ELG 55421 Q53F19 NCBP3 human S100 28846223 AkRFHFRsEVNLAQR X +CHEK1 Chk1 O14757 human ZBTB11 27107 O95625 ZBTB11 human S511 15416798 RSRLRQRsVNEGAyI X +CHEK1 Chk1 O14757 human CDC25A 993 P30304 CDC25A human T507 450483 KFRTKSRtWAGEKsK X X +CHEK1 Chk1 O14757 human FANCE 2178 Q9HB96 FANCE human T346 476781 LGLLRLCtWLLALSP FA_FANCE X X +CHEK1 Chk1 O14757 human Src 6714 P12931 SRC human Y419 448234 RLIEDNEytARQGAk PK_Tyr_Ser-Thr X 2101; 6943; 59548; 70926; 78740; 94361; 17320 +CHEK1 Chk1 O14757 human FYTTD1 84248 Q96QD9 FYTTD1 human T205 28846231 KVQAQLNtEQLLDDV FYTT X +CHEK1 Chk1 O14757 human CDK1 983 P06493 CDK1 human S208 28846209 kPLFHGDsEIDQLFR Pkinase X +CHEK1 Chk1 O14757 human MIG-6 313729 P05432 Errfi1 rat S250 3215403 RRLRRsHsGPAGSFN X +CHEK1 Chk1 O14757 human NFkB-p105 18033 P25799 Nfkb1 mouse S335 449967 FVQLRRKsDLETSEP RHD_dimer X +CHEK1 Chk1 O14757 human PLK1 5347 P53350 PLK1 human S137 448138 LELCRRRsLLELHkR Pkinase X X +CHEK1 Chk1 O14757 human SKAR 84271 Q9BY77 POLDIP3 human S63 18015794 ARQKIGLsDArLKLG X +CHEK1 Chk1 O14757 human BLM 641 P54132 BLM human S502 34666301 HLQksFVsSNWAEtP BDHCT_assoc X X +CHEK1 Chk1 O14757 human RPL13 6137 P26373 RPL13 human T170 28846292 KEKARVItEEEkNFk Ribosomal_L13e X +CHEK1 Chk1 O14757 human LIG1 3978 P18858 LIG1 human S76 449246 EEEDEALsPAkGQKP X +CHEK1 Chk1 O14757 human CK2B 1460 P67870 CSNK2B human T213 2902202 NFksPVktIR_____ X +CHEK1 Chk1 O14757 human Syk 6850 P43405 SYK human S295 7445408 GIISRIKsysFPKPG X X +CHEK1 Chk1 O14757 human KPNA1 3836 P52294 KPNA1 human S18 28846243 LKsYKNKsLNPDEMR IBB X +CHEK1 Chk1 O14757 human MINK 50488 Q8N4C8 MINK1 human T280 28846267 TYLSRPPtEQLLKFP Pkinase X +CHEK1 Chk1 O14757 human CDC25C 995 P30307 CDC25C human S216 448418 sGLyRsPsMPENLNR M-inducer_phosp X 9528; 4901; 30790 +CHEK1 Chk1 O14757 human SLTM 79811 Q9NWH9 SLTM human S815 27459212 TARREDPsFERYPKN X +CHEK1 Chk1 O14757 human MEK1 5604 Q02750 MAP2K1 human T55 28846257 KRLEAFLtQkQKVGE X +CHEK1 Chk1 O14757 human TICRR 90381 Q7Z2Z1 TICRR human S1894 38520201 FSRRRPIsRTYtRKK X +CHEK1 Chk1 O14757 human Rb 5925 P06400 RB1 human S612 447977 MyLsPVRsPKKKGsT X +CHEK1 Chk1 O14757 human NFkB-p105 4790 P19838 NFKB1 human S328 22771100 INItkPAsVFVQLRR RHD_dimer X X +CHEK1 Chk1 O14757 human OSBPL11 114885 Q9BXB4 OSBPL11 human S189 468350 PIsQRRPsQNAIsFF X +CHEK1 Chk1 O14757 human FANCE 2178 Q9HB96 FANCE human S374 476782 LFLGRILsLTSSASR FA_FANCE X X +CHEK1 Chk1 O14757 human RAP80 51720 Q96RL1 UIMC1 human S627 472426 HSEGRLLsFLEQsEH X +CHEK1 Chk1 O14757 human CDC25A 993 P30304 CDC25A human S279 449129 VLKRPErsQEEsPPG M-inducer_phosp X X +CHEK1 Chk1 O14757 human CDC25A 993 P30304 CDC25A human S293 449128 GSTKrRKsMsGASPk M-inducer_phosp X X +CHEK1 Chk1 O14757 human SIN3A 25942 Q96ST3 SIN3A human T434 9257992 IRRHPtGttPPVKKK X +CHEK1 Chk1 O14757 human SRm300 23524 Q9UQ35 SRRM2 human S1497 457062 PQtPRPRsRsPssPE X +CHEK1 Chk1 O14757 human CDC25B 994 P30305 CDC25B human S230 470115 AFAQRPssAPDLMCL M-inducer_phosp X X +CHEK1 Chk1 O14757 human NUP153 9972 P49790 NUP153 human S330 468335 ADAkRIPsIVssPLN Nup153 X +CHEK1 Chk1 O14757 human TNK1 8711 Q13470 TNK1 human S502 483166 RMKGIsRsLEsVLsL X +CHEK1 Chk1 O14757 human EML3 256364 Q32P44 EML3 human S176 483689 KLSRkAIssANLLVR X +CHEK1 Chk1 O14757 human CEP170B 283638 Q9Y4F5 CEP170B human S655 3217287 QGLPVPGsPGGQKWV X +CHEK1 Chk1 O14757 human LMO7 4008 Q8WWI1 LMO7 human S1510 457018 GIMRRGEsLDNLDsP X +CHEK1 Chk1 O14757 human MDM4 4194 O15151 MDM4 human S367 457676 PDCRRtIsAPVVRPk X X +CHEK1 Chk1 O14757 human NFkB-p105 18033 P25799 Nfkb1 mouse S246 1170753400 DsKAPNAsNLKIVRM X +PRKACA PKACA P17612 human GLI1 2735 P08151 GLI1 human T374 457674 PGCTkRYtDPSSLRK zf-C2H2 X +PRKACA PKACA P17612 human CUTL1 1523 P39880 CUX1 human S1270 460701 YQQKPYPsPKTIEDL Homeodomain X +PRKACA PKACA P17612 human GSK3B 84027 P18266 Gsk3b rat S9 449111 SGRPRTTsFAESCKP X 9336; 9331; 9327; 9323; 9322; 9325; 5558; 8566; 79774; 8466; 25462; 14026; 14332; 14310; 14630 +PRKACA PKACA P17612 human CDK16 5127 Q00536 CDK16 human S119 453450 EDINkRLsLPADIRL X +PRKACA PKACA P17612 human eNOS 4846 P29474 NOS3 human T495 447885 TGITRKKtFKEVANA X 9574 +PRKACA PKACA P17612 human MAP2 4133 P11137 MAP2 human S1679 456808 NVKsKIGstDNIKYQ Tubulin-binding X X +PRKACA PKACA P17612 human SHIP 16331 Q9ES52 Inpp5d mouse S1161 4778452 AVLQLQHsKGRDyRD X +PRKACA PKACA P17612 human CIITA 4261 P33076 CIITA human S1050 448442 AASLLRLsLYNNCIC LRR_6 X X +PRKACA PKACA P17612 human MAPKAPK5 8550 Q8IW41 MAPKAPK5 human S115 18704700 GELFHRIsQHRHFTE Pkinase X +PRKACA PKACA P17612 human RKIP 29542 P31044 Pebp1 rat S51 3189670 TQVMNRPssIsWDGL PBP X +PRKACA PKACA P17612 human CAMKK2 10645 Q96RR4 CAMKK2 human S495 469882 kTMIRKRsFGNPFEG X 16737; 35392 +PRKACA PKACA P17612 human NEDD4L 23327 Q96PU5 NEDD4L human S342 453438 ssRLRsCsVtDAVAE X X 12146 +PRKACA PKACA P17612 human SRC-3 8202 Q9Y6Q9 NCOA3 human S857 453084 PPYNRAVsLDsPVsV X +PRKACA PKACA P17612 human RASD1 19416 O35626 Rasd1 mouse S253 50402002 APFARRPsVHSDLMY X +PRKACA PKACA P17612 human CAMKK1 60341 P97756 Camkk1 rat S52 2864202 PPRARAAsVIPGsAs X +PRKACA PKACA P17612 human PPP2R5D 5528 Q14738 PPP2R5D human S75 457389 QLSkIkysGGPQIVk X +PRKACA PKACA P17612 human Rb 5925 P06400 RB1 human S780 447978 strPPtLsPIPHIPr Rb_C X 9307; 3590; 8180 +PRKACA PKACA P17612 human MYBPC1 iso2 109272 G0YZM8 Mybpc1 mouse S204 4738635 IRSAFKRsGEGQEDA X +PRKACA PKACA P17612 human HEXIM1 10614 O94992 HEXIM1 human S158 25680402 KKHRRRPsKKKRHWk X X +PRKACA PKACA P17612 human SHIP 16331 Q9ES52 Inpp5d mouse S972 4778440 PPsQPPLsPKKFsSS X +PRKACA PKACA P17612 human ATP6V1A 11964 P50516 Atp6v1a mouse S175 14913505 LPPRNRGsVTYIAPP ATP-synt_ab_Xtn X X +PRKACA PKACA P17612 human CACNA1D 29716 P27732 Cacna1d rat T2147 6062706 EMESAAStLLNGsVC CAC1F_C X +PRKACA PKACA P17612 human GLI3 2737 P10071 GLI3 human S980 25780315 VHAPRRCsDGGAHGY X X +PRKACA PKACA P17612 human APOA1BP 246703 Q8K4Z3 Naxe mouse S43 4763049 WGTQRRGsEtMAGAA X +PRKACA PKACA P17612 human CACNA1C 775 Q13936 CACNA1C human S1535 460572 DYLTRDWsILGPHHL Ion_trans X +PRKACA PKACA P17612 human RYR2 20191 E9Q401 Ryr2 mouse S2030 455603 TIRGRLLsLVEkVTY X X +PRKACA PKACA P17612 human Kv7.2 iso4 3785 O43526-4 KCNQ2 human S455 4788663 SKVPKSWsFGDRSRA KCNQ_channel X +PRKACA PKACA P17612 human PLCG1 5335 P19174 PLCG1 human S1248 448665 HGrAREGsFEsRyQQ X X 4510; 13349; 8713 +PRKACA PKACA P17612 human ASIC1 iso1 41 P78348-1 ASIC1 human S525 449558 QKEAKRSsADKGVAL X X +PRKACA PKACA P17612 human PPAR-alpha 25747 P37230 Ppara rat T129 457548 CKGFFRRtIRLKLAY zf-C4 X +PRKACA PKACA P17612 human DISC1 27185 Q9NRI5 DISC1 human S58 18942701 GPGIGFLsPAVGTLF X +PRKACA PKACA P17612 human CASP9 842 P55211 CASP9 human S99 471400 NRQAAkLskPTLENL X +PRKACA PKACA P17612 human MYBPC3 4607 Q14896 MYBPC3 human S284 471080 AGGGRRIsDsHEDtG X +PRKACA PKACA P17612 human GATA4 2626 P43694 GATA4 human S262 450013 IkPQRRLsAsRRVGL X +PRKACA PKACA P17612 human neurabin 1 55607 Q9ULJ8 PPP1R9A human S460 455523 ANRKIKFsSAPIKVF PDZ_5 X +PRKACA PKACA P17612 human CHCHD3 54927 Q9NX63 CHCHD3 human T11 4038300 TTSTRRVtFEADENE X +PRKACA PKACA P17612 human E2F1 1869 Q01094 E2F1 human T130 1870773101 GEkSRYEtSLNLttK E2F_TDP X +PRKACA PKACA P17612 human SHIP 16331 Q9ES52 Inpp5d mouse S173 15621803 TLFQRLQsMDTSGLP X +PRKACA PKACA P17612 human DACT1 51339 Q9NYF0 DACT1 human S827 18159800 KKILRFRsGSLKLMT Dapper X +PRKACA PKACA P17612 human HSL 16890 P54310 Lipe mouse S557 448803 PtESMRRsVsEAALA X 4139 +PRKACA PKACA P17612 human MARK3 4140 P27448 MARK3 human T507 470095 GGMtRRNtyVCsERT X X +PRKACA PKACA P17612 human PAR-4 64513 Q62627 Pawr rat T155 456964 LREKRRStGVVNIPA X X 2329 +PRKACA PKACA P17612 human NHE3 24784 P26433 Slc9a3 rat S552 450899 AEGERRGsLAFIRSP X +PRKACA PKACA P17612 human GRK1 24013 Q9WVL4 Grk1 mouse S21 456353 AFIAARGsFDGSSTP X +PRKACA PKACA P17612 human RPS19 P17074 Rps19 rat S59 7113803 WFYTRAAsTARHLYL Ribosomal_S19e X +PRKACA PKACA P17612 human LC3A 362245 Q6XVN8 Map1lc3a rat S12 15116600 RPFKQRRsFADRCKE X +PRKACA PKACA P17612 human AID 11628 Q9WVE0 Aicda mouse T27 471423 WAKGRHEtYLCYVVK APOBEC2 X +PRKACA PKACA P17612 human RASGRF1 5923 Q13972 RASGRF1 human S927 448487 KEKYRRMsLASAGFP X X +PRKACA PKACA P17612 human H1F1 80838 P43275 H1f1 mouse S129 3302705 VsVKAKAsGAAKKPK X +PRKACA PKACA P17612 human Spinophilin 217124 Q6R891 Ppp1r9b mouse S94 448728 SDRGVRLsLPRAssL X +PRKACA PKACA P17612 human RASGRP2 19395 Q9QUG9 Rasgrp2 mouse S117 468585 EGNRRHssLIDIESV X X +PRKACA PKACA P17612 human CFTR 1080 P13569 CFTR human S670 3333405 TETLHRFsLEGDAPV CFTR_R X +PRKACA PKACA P17612 human CCND1 595 P24385 CCND1 human S197 451828 ATDVKFIsNPPSMVA Cyclin_C X +PRKACA PKACA P17612 human RAP1B 327708 P61223 RAP1B cow S179 451799 PGKARKKssCQLL__ X +PRKACA PKACA P17612 human DUOX1 53905 Q9NRD9 DUOX1 human S955 6370301 KDLCRRAsyIsQDMI X X +PRKACA PKACA P17612 human SCN5A 6331 Q14524 SCN5A human S524 27281504 RTsMKPRssrGsIFt Na_trans_cytopl X +PRKACA PKACA P17612 human NFkB-p105 4790 P19838 NFKB1 human S337 449967 FVQLRRKsDLETSEP RHD_dimer X X +PRKACA PKACA P17612 human MEN1 29417 Q9WVR8 Men1 rat S487 18012114 RRGPRREsKPEEPPP Menin X X +PRKACA PKACA P17612 human MST4 51765 Q9P289 STK26 human T178 4274125 DtQIkRNtFVGtPFW Pkinase X +PRKACA PKACA P17612 human Kv11.1 3757 Q12809 KCNH2 human S1137 4696829 EGPTRRLsLPGQLGA X X +PRKACA PKACA P17612 human PLB 5350 P26678 PLN human S16 448114 RSAIRRAstIEMPQQ Phospholamban X X 8496 +PRKACA PKACA P17612 human PDE4A 25638 P54748 Pde4a rat S140 458389 TTSQRREsFLYRSDs X +PRKACA PKACA P17612 human CACNA1D 29716 P27732 Cacna1d rat S45 6062713 GPTSQPNssKQtVLs X +PRKACA PKACA P17612 human FOXO1A 2308 Q12778 FOXO1 human S153 1253812000 AGQPRKSsSSRRNAW X X +PRKACA PKACA P17612 human MYBPC3 4607 Q14896 MYBPC3 human S311 2846505 sFRtPRDsKLEAPAE X +PRKACA PKACA P17612 human TNNI3 511094 P08057 TNNI3 cow S44 450690 AKKKSKIsAsRKLQL X +PRKACA PKACA P17612 human MAZ 100008693 O97600 MAZ rabbit T386 449095 KDRLRAHtVRHEEKV X +PRKACA PKACA P17612 human AMPKA1 105787 Q5EG47 Prkaa1 mouse S496 450431 AtPQRsGsIsNYRsC AdenylateSensor X 4185; 4184; 2537 +PRKACA PKACA P17612 human CAPN1 823 P07384 CAPN1 human S474 27445498 ANAsRARsEQFINLR Calpain_III X +PRKACA PKACA P17612 human CACNA1C 100101555 P15381 CACB rabbit S1928 455278 ASLGRRAsFHLECLK CAC1F_C X X +PRKACA PKACA P17612 human CAMKK2 10645 Q96RR4 CAMKK2 human S511 2861414 RREERsLsAPGNLLT X 12818 +PRKACA PKACA P17612 human PHOX2A 401 O14813 PHOX2A human S153 9400302 RKQERAAsAkGAAGA X X +PRKACA PKACA P17612 human GFAP 2670 P14136 GFAP human S38 449621 LGPGTRLsLARMPPP Filament_head X +PRKACA PKACA P17612 human ETV1 2115 P50549 ETV1 human S216 3059600 PMYQRQMsEPNIPFP ETS_PEA3_N X X +PRKACA PKACA P17612 human SRF 6722 P11831 SRF human T159 449631 DNkLRRYtTFsKRkT SRF-TF X X +PRKACA PKACA P17612 human DRP1 10059 O00429 DNM1L human S637 483971 VPVARKLsAREQRDC X X 4867; 6319 +PRKACA PKACA P17612 human HSL 3991 Q05469 LIPE human S951 450195 GFHPRRssQGAtQMP Abhydrolase_3 X +PRKACA PKACA P17612 human Tau 17762 P10637 Mapt mouse S701 449132 DtsPRHLsNVsstGs X +PRKACA PKACA P17612 human NFL 18039 P08551 Nefl mouse S56 451024 ssLsVRRsyssSSGs Filament_head X +PRKACA PKACA P17612 human RYR2 689560 B0LPN4 Ryr2 rat S2804 458801 IsQTsQVsIDAAHGY X X +PRKACA PKACA P17612 human VASP 7408 P50552 VASP human T278 448381 LARRRKAtQVGEktP X +PRKACA PKACA P17612 human STAR 101844174 P70114 Star hamster S55 450439 ISQVRRRssLLGSQL X +PRKACA PKACA P17612 human Kv11.1 3757 Q12809 KCNH2 human S890 3893409 RQRKRKLsFRRRtDK X X +PRKACA PKACA P17612 human TRPC5 7224 Q9UL62 TRPC5 human S794 20834807 SGGARAKsKsVSFNL X +PRKACA PKACA P17612 human CK1D 64462 Q06486 Csnk1d rat S370 483997 MERERKVsMRLHRGA X X +PRKACA PKACA P17612 human smMLCK 396445 P11799 MYLK chicken S140 41411900 KTPGGRLsVPPVEHR X +PRKACA PKACA P17612 human IGFBP1 3484 P08833 IGFBP1 human S199 51637400 ETsGEEIsKFYLPNC Thyroglobulin_1 X +PRKACA PKACA P17612 human gephyrin 64845 Q03555 Gphn rat S337 481401 NILRAsHsAVDITKV X +PRKACA PKACA P17612 human RGS4 100009014 Q0R4E4 RGS4 rabbit S52 469585 VVVCQRVsQEEVKKW X +PRKACA PKACA P17612 human CACNA1B 257648 Q02294 Cacna1b rat S2126 467286 SEKQRFYsCDRFGsR X +PRKACA PKACA P17612 human desmin 1674 P17661 DES human T17 449613 RVssYRRtFGGAPGF Filament_head X +PRKACA PKACA P17612 human CHKB 1120 Q9Y259 CHKB human S39 5208526 TPKRRRAssLsRDAE X X +PRKACA PKACA P17612 human ADRB2 154 P07550 ADRB2 human S345 447910 ELLCLRRssLKAyGN X +PRKACA PKACA P17612 human CASK 29647 Q62915 Cask rat S562 12568400 MLREMRGsITFKIVP PDZ X +PRKACA PKACA P17612 human CEACAM1 634 P13688 CEACAM1 human S461 6311908 FGKtGRAsDQRDLTE X +PRKACA PKACA P17612 human NMDAR1 14810 P35438 Grin1 mouse S897 448256 sFKRRRssKDTSTGG X +PRKACA PKACA P17612 human HCN4 330953 O70507 Hcn4 mouse S1113 4699512 RAGGGSGsSGGLGPP X +PRKACA PKACA P17612 human HSD17B13 345275 Q7Z5P4 HSD17B13 human S33 4765436 FIPQRRKsVAGEIVL X X +PRKACA PKACA P17612 human mGluR7 81672 P35400 Grm7 rat S862 2846504 NVQKRKRsFKAVVTA X +PRKACA PKACA P17612 human PDE4D iso2 5144 Q08499-2 PDE4D human S13 2188800 NFPFRRHsWICFDVD X +PRKACA PKACA P17612 human CACNA1D 29716 P27732 Cacna1d rat S121 6062715 PIRRACIsIVDWKPF X +PRKACA PKACA P17612 human IGFBP1 3484 P08833 IGFBP1 human S144 451659 NFHLMAPsEEDHSIL X +PRKACA PKACA P17612 human PFKP 100009526 P47859 PFKP rabbit S12 458323 VSASPRGsYRKFLEH X +PRKACA PKACA P17612 human 14-3-3 zeta 7534 P63104 YWHAZ human S58 449833 VVGARRssWRVVssI 14-3-3 X X 52631 +PRKACA PKACA P17612 human ACC1 iso2 60581 P11497-2 Acaca rat S1192 448290 TSHPNRMsFASNLNH ACC_central X +PRKACA PKACA P17612 human STMN1 29332 P13668 Stmn1 rat S63 448557 AAEERRKsHEAEVLk Stathmin X +PRKACA PKACA P17612 human VAX2 24113 Q9WTP9 Vax2 mouse S170 470130 RDLEKRAssSASEAF X X +PRKACA PKACA P17612 human TXA2-R iso2 6915 P21731-2 TBXA2R human T332 18790000 TRPRRsLtLWPSLEY X +PRKACA PKACA P17612 human IP3R1 16438 P11881 Itpr1 mouse S1588 450681 RNAARRDsVLAAsRD X X +PRKACA PKACA P17612 human BRSK2 9024 Q8IWQ3 BRSK2 human T260 470033 VDAARRLtLEHIQKH Pkinase X +PRKACA PKACA P17612 human NUDE1 iso1 54820 Q9NXR1-1 NDE1 human S306 476557 DGGERRPsstsVPLG NUDE_C X +PRKACA PKACA P17612 human HIF1A 3091 Q16665 HIF1A human S465 56589707 tPkPLRSsADPALNQ X +PRKACA PKACA P17612 human PARP1 142 P09874 PARP1 human S465 34729900 FLQDVSAsTkSLQEL X X +PRKACA PKACA P17612 human FcoR 100503924 P0DJI6 Fcor mouse T93 25244200 DLNSQRStCCCLLNA X +PRKACA PKACA P17612 human ACC1 60581 P11497 Acaca rat S77 448291 LAFHMRSsMsGLHLV X +PRKACA PKACA P17612 human TRPC6 7225 Q9Y210 TRPC6 human T70 470868 RLAHRRQtVLREKGR X X +PRKACA PKACA P17612 human CTPS 1503 P17812 CTPS1 human T455 473570 MRLGKRRtLFQTkNs GATase X +PRKACA PKACA P17612 human NFAT2 4772 O95644 NFATC1 human S245 448861 PSTsPRAsVTEEsWL X X +PRKACA PKACA P17612 human DDX25 29118 Q9UHL0 DDX25 human T239 1868227101 KLKLIDLtKIRVFVL DEAD X +PRKACA PKACA P17612 human H1R 3269 P35367 HRH1 human S398 450937 WKRLRsHsRQyVSGL 7tm_1 X +PRKACA PKACA P17612 human Kir4.1 29718 P49655 Kcnj10 rat S377 2243103 sALSVRIsNV_____ X +PRKACA PKACA P17612 human RGS18 64407 Q9NS28 RGS18 human S216 4772683 PTNLRRRsRsFTCNE X X +PRKACA PKACA P17612 human TPH1 7166 P17752 TPH1 human S260 36439500 TQYVRHSsDPFYTPE Biopterin_H X +PRKACA PKACA P17612 human SCN5A 6331 Q14524 SCN5A human S525 451568 TsMKPRssrGsIFtF Na_trans_cytopl X +PRKACA PKACA P17612 human rabphilin 3A 171039 P47709 Rph3a rat S234 455904 GPPTRRAsEARMSTT X +PRKACA PKACA P17612 human Ret 5979 P07949 RET human S696 451267 SSGARRPsLDsMENQ X X +PRKACA PKACA P17612 human CFTR 1080 P13569 CFTR human S753 451646 EAILPRIsVISTGPT CFTR_R X +PRKACA PKACA P17612 human CACNA1D 29716 P27732 Cacna1d rat T504 6062720 KRRGAAKtGPSGCRR X +PRKACA PKACA P17612 human AP-2 alpha 7020 P05549 TFAP2A human S239 457400 AEVQRRLsPPECLNA TF_AP-2 X X +PRKACA PKACA P17612 human PDE4B 5142 Q07343 PDE4B human S133 449097 GHSQRREsFLYRsDs X +PRKACA PKACA P17612 human TXA2-R iso2 6915 P21731-2 TBXA2R human S330 18790001 LSTRPRRsLtLWPSL X X +PRKACA PKACA P17612 human CHKB 1120 Q9Y259 CHKB human S40 3857922 PKRRRAssLsRDAER X X +PRKACA PKACA P17612 human Spinophilin 84686 O35274 Ppp1r9b rat S100 448729 LsLPRAssLNENVDH X +PRKACA PKACA P17612 human GJD2 14617 O54851 Gjd2 mouse S293 471387 GAQAKRKsVYEIRNK X +PRKACA PKACA P17612 human TNNI3 511094 P08057 TNNI3 cow S25 448424 PPVRRRssANYRAYA Troponin-I_N X +PRKACA PKACA P17612 human OFD1 8481 O75665 OFD1 human S735 480374 GTSSRRLsstPLPkA X X +PRKACA PKACA P17612 human AID 57379 Q9GZX7 AICDA human S38 457604 YVVKRRDsATsFsLD APOBEC2 X X +PRKACA PKACA P17612 human HSP27 3315 P04792 HSPB1 human T143 471871 RCFtRkytLPPGVDP HSP20 X +PRKACA PKACA P17612 human SHIP 16331 Q9ES52 Inpp5d mouse S1023 15406096 FENPLyGsVSSFPKL X +PRKACA PKACA P17612 human GIRK4 3762 P48544 KCNJ5 human S412 27523603 EPKGLGGsREARGSV X +PRKACA PKACA P17612 human Titin 84015 XP_008773743 Ttn rat S3658 29618902 ETSARGLsVQAFDSE X +PRKACA PKACA P17612 human ITPKA 228550 Q8R071 Itpka mouse S119 4763186 LQQPRRLstSSLSST X +PRKACA PKACA P17612 human ENSA 2029 O43768 ENSA human S109 477819 DLPQRkssLVtskLA Endosulfine X +PRKACA PKACA P17612 human TRPA1 8989 O75762 TRPA1 human S972 62873400 AEVQKHAsLKRIAMQ Ion_trans X +PRKACA PKACA P17612 human GluR1 14799 P23818 Gria1 mouse S863 448566 tstLPRNsGAGASGG X 8084 +PRKACA PKACA P17612 human HIR 116649 P52190 Kcnj4 rat S444 9819904 NISYRREsAI_____ X +PRKACA PKACA P17612 human RGS13 6003 O14921 RGS13 human T41 15785722 SFENLMAtKYGPVVy RGS X +PRKACA PKACA P17612 human STAR 25557 P97826 Star rat S55 450439 MGQVRRRssLLGSQL X +PRKACA PKACA P17612 human CTNNB1 1499 P35222 CTNNB1 human S675 457120 QDykKRLsVELtsSL X X 9567; 4176; 68076 +PRKACA PKACA P17612 human CACNA1D 29716 P27732 Cacna1d rat S923 6062711 IAPIPEGsAFFILsK X +PRKACA PKACA P17612 human PKACA 282322 P00517 PRKACA cow S140 469999 LRRIGRFsEPHARFY Pkinase X +PRKACA PKACA P17612 human GSTA4 2941 O15217 GSTA4 human S189 455666 QEYTVKLsNIPtIKR GST_C_3 X +PRKACA PKACA P17612 human PFKFB2 5208 O60825 PFKFB2 human S466 448460 PVRMRRNsFtPLssS X +PRKACA PKACA P17612 human CFTR 1080 P13569 CFTR human S737 449981 EPLERRLsLVPDSEQ CFTR_R X X +PRKACA PKACA P17612 human Tau iso2 4137 P10636-2 MAPT human S320 449132 DTsPRHLsNVSSTGS X +PRKACA PKACA P17612 human TRPV4 63873 Q9EPK8 Trpv4 mouse S824 4777181 LRRDRWssVVPRVVE X +PRKACA PKACA P17612 human RRAD 6236 P55042 RRAD human S273 457396 AGTRRREsLGKKAKR X +PRKACA PKACA P17612 human Src 396442 P00523 SRC chicken S17 448231 DPsQRRRsLEPPDST X X +PRKACA PKACA P17612 human TH iso4 7054 P07101-4 TH human S44 448545 RFIGRRQsLIEDARK TOH_N X 2791 +PRKACA PKACA P17612 human RAP1GAP 5909 P47736 RAP1GAP human S499 3190708 PFGsRRssAIGIENI X X +PRKACA PKACA P17612 human CACNA1D 29716 P27732 Cacna1d rat S858 6062719 EVNQIANsDNKVtID X +PRKACA PKACA P17612 human KCNN2 3781 Q9H2S1 KCNN2 human S464 460687 QAIHQLRsVkMEQRK CaMBD X X +PRKACA PKACA P17612 human PRKD1 18760 Q62101 Prkd1 mouse S427 4960330 KHTKRRSsTVMKEGW X X +PRKACA PKACA P17612 human NFAT2 4772 O95644 NFATC1 human S269 448862 PCNKRKYsLNGRQPP X X +PRKACA PKACA P17612 human CACNA1D 29716 P27732 Cacna1d rat S1944 6062708 DSPIGYDsRRsPRRR CAC1F_C X +PRKACA PKACA P17612 human PPP1R1A 5502 Q13522 PPP1R1A human T35 447759 QIRRRRPtPATLVLT DARPP-32 X +PRKACA PKACA P17612 human DNCLI1 252902 Q9QXU8 Dync1li1 rat T213 3217776 AsPQRRAtAAQEDRD DLIC X X +PRKACA PKACA P17612 human TRIM71 131405 Q2Q1W2 TRIM71 human S3 18914372 _____MAsFPETDFQ X +PRKACA PKACA P17612 human MAP2 iso3 25595 P15146-3 Map2 rat S184 470351 KSPEKRSsLPRPsSI X +PRKACA PKACA P17612 human QSK 23387 Q9Y2K2 SIK3 human S626 3216774 FsPVRRFsDGAAsIQ X +PRKACA PKACA P17612 human CACNA1H 8912 O95180 CACNA1H human S1107 6729300 LPDsRRGsSsSGDPP X +PRKACA PKACA P17612 human myomesin 2 9172 P54296 MYOM2 human S76 466426 RVCAKRVstQEDEEQ X X +PRKACA PKACA P17612 human CFTR 1080 P13569 CFTR human S712 455297 INsIRKFsIVQKTPL CFTR_R X X +PRKACA PKACA P17612 human SHIP 16331 Q9ES52 Inpp5d mouse S269 4778398 ITMVAKLsQLTSLLS X +PRKACA PKACA P17612 human ABHD5 67469 Q9DBL9 Abhd5 mouse S239 36744500 PDFKRKYsSMFEDDT X +PRKACA PKACA P17612 human GIRK1 50599 P63251 Kcnj3 rat T407 10769101 PsKLQKItGREDFPK X +PRKACA PKACA P17612 human HIF1A 3091 Q16665 HIF1A human T63 56589703 KASVMRLtISyLRVR X X +PRKACA PKACA P17612 human SYT12 171180 Q920N7 Syt12 mouse S97 473040 GPPSRKGsLSIEDTF X +PRKACA PKACA P17612 human PKD2L1 9033 Q9P0L9 PKD2L1 human S685 394791405 KLGRsIVssPQGKSG X +PRKACA PKACA P17612 human TAL1 21349 P22091 Tal1 mouse S172 4704529 NRVKRRPsPYEMEIS X X +PRKACA PKACA P17612 human ABCA1 19 O95477 ABCA1 human S1042 455499 GGMQRKLsVALAFVG TM; ABC_tran X +PRKACA PKACA P17612 human LRRK2 66725 Q5S006 Lrrk2 mouse S935 4725898 NAQRHSNsLGPVFDH X X 59576 +PRKACA PKACA P17612 human VTN 7448 P04004 VTN human S397 452178 NQNsRRPsRATWLSL X +PRKACA PKACA P17612 human ORAI1 84876 Q96D31 ORAI1 human S34 48990000 sRRsRRRsGDGEPPG X +PRKACA PKACA P17612 human CPEB3 208922 Q7TN99 Cpeb3 mouse S420 54003200 GRRRGRssLFPFEDA X X +PRKACA PKACA P17612 human KCNN4 3783 O15554 KCNN4 human S334 452145 KHtRRKEsHAARRHQ CaMBD X +PRKACA PKACA P17612 human NLGN2 117096 Q62888 Nlgn2 rat S714 487169 ELRCRRLsPPGGSGS X X +PRKACA PKACA P17612 human CACNA1C BAA34185.2 CACNA1C guinea pig S1574 467228 VACKRLVsMNMPLNS GPHH X X +PRKACA PKACA P17612 human HCN4 330953 O70507 Hcn4 mouse S1140 4699517 TLPRKtssGsLPPPL X +PRKACA PKACA P17612 human perilipin 1 103968 Q8CGN5 Plin1 mouse S492 459628 EKPARRVsDsFFRPs X +PRKACA PKACA P17612 human AKAP12 9590 Q02952 AKAP12 human S772 34663200 LVtPRKksKSkLEEK WSK X X +PRKACA PKACA P17612 human RPS19 P17074 Rps19 rat S90 7113804 QRNGVRPsHFSRGSK Ribosomal_S19e X +PRKACA PKACA P17612 human GIRK1 50599 P63251 Kcnj3 rat S385 4706226 NSKERHNsVECLDGL X +PRKACA PKACA P17612 human PKACA 282322 P00517 PRKACA cow S54 9768111 IKtLGTGsFGRVMLV Pkinase X +PRKACA PKACA P17612 human Tau iso8 4137 P10636-8 MAPT human S320 450139 VDLskVtskCGsLGN Tubulin-binding X +PRKACA PKACA P17612 human syndecan-1 20969 P18828 Sdc1 mouse S286 469564 MKKkDEGsYsLEEPK Syndecan X X +PRKACA PKACA P17612 human PPP1R14A 94274 Q96A00 PPP1R14A human T38 449098 QkRHARVtVkYDRRE PP1_inhibitor X +PRKACA PKACA P17612 human GCM1 8521 Q9NP62 GCM1 human S275 18788304 LsSSRTYsSGDLLPP X X +PRKACA PKACA P17612 human p47phox 653361 P14598 NCF1 human S320 451726 QRsRKRLsQDAYRRN NECFESHC X +PRKACA PKACA P17612 human Claudin-16 155268 Q91Y55 Cldn16 rat S217 2872000 AGVSMAKsyKAPRTE X X +PRKACA PKACA P17612 human GluR4 29629 P19493 Gria4 rat S862 448810 TRNKARLsITGSVGE X X +PRKACA PKACA P17612 human PDE4B 18578 Q8VBU5 Pde4b mouse S118 449097 GHSQRREsFLYRSDs X +PRKACA PKACA P17612 human RAP1GAP2 23108 Q684P5 RAP1GAP2 human S7 455267 _MFGRKRsVsFGGFG X +PRKACA PKACA P17612 human NOXA1 10811 Q86UR1 NOXA1 human S172 990300 DQVQRRGsLPPRQVP X X +PRKACA PKACA P17612 human UHRF1 29128 Q96T88 UHRF1 human S298 2902206 DNPMRRKsGPSCkHC X X +PRKACA PKACA P17612 human CACNA1D 29716 P27732 Cacna1d rat S519 6062714 WGQAIsKsKLRSHGA X +PRKACA PKACA P17612 human ER-alpha 2099 P03372 ESR1 human S236 448739 IDKNRRKsCQACRLR zf-C4 X X +PRKACA PKACA P17612 human CDC25B 12531 P30306 Cdc25b mouse S321 448409 QRLFRsPsMPCSVIR M-inducer_phosp X X +PRKACA PKACA P17612 human SMTNL1 68678 Q99LM3 Smtnl1 mouse S301 2755200 RAPERRVsAPSRPRG X +PRKACA PKACA P17612 human CACNA1S 100009585 P07293 CACNA1S rabbit S1575 6064601 PEIRRTIsGDLtAEE X +PRKACA PKACA P17612 human SMN 6606 Q16637 SMN1 human S187 9316349 sDNIkPksAPWNsFL SMN X +PRKACA PKACA P17612 human PLB 414755 P61012 PLN dog S16 448114 RSAIRRAstIEMPQQ Phospholamban X 8496 +PRKACA PKACA P17612 human MYBPC3 4607 Q14896 MYBPC3 human S304 471081 SLLKKRDsFRtPRDs X +PRKACA PKACA P17612 human HIF1A 3091 Q16665 HIF1A human S727 56589705 RkMEHDGsLFQAVGI X +PRKACA PKACA P17612 human PPP2R5D 21770 Q7TNL5 Ppp2r5d mouse S68 457389 QLSKIKYsGGPQIVK X +PRKACA PKACA P17612 human JMJD1A 55818 Q9Y4C1 KDM3A human S265 453894 GAVKRKssENNGTLV X X +PRKACA PKACA P17612 human MEF2B iso2 100271849 Q02080-2 MEF2B human S324 29649500 sIkSERLsPAPGGPG X +PRKACA PKACA P17612 human PHF2 5253 O75151 PHF2 human S899 4169511 RSKKRKGsDDAPYsP X X +PRKACA PKACA P17612 human PAH 24616 P04176 Pah rat S16 449074 GVLSRKLsDFGQETS X +PRKACA PKACA P17612 human smMLCK 100009143 P29294 MYLK rabbit S1011 468782 SsTGSPTsPLTAERL X X +PRKACA PKACA P17612 human PHF2 5253 O75151 PHF2 human S1056 11138771 FLTQRRPsAssPNNN X X +PRKACA PKACA P17612 human TNNI3 7137 P19429 TNNI3 human S23 448423 PAPIRRRssNyRAyA Troponin-I_N X X 4004 +PRKACA PKACA P17612 human HDAC4 9759 P56524 HDAC4 human S265 4737971 QKVAERRssPLLRRK X X +PRKACA PKACA P17612 human profilin 1 5216 P07737 PFN1 human S138 2850008 MAsHLRRsQy_____ Profilin X X +PRKACA PKACA P17612 human CDK16 5127 Q00536 CDK16 human S110 453449 NHPPRkIstEDINkR X +PRKACA PKACA P17612 human TFAM 7019 Q00059 TFAM human S56 27530801 CPKkPVssYLRFskE HMG_box X +PRKACA PKACA P17612 human GPKOW 27238 Q92917 GPKOW human T316 21127301 GTASSRktLWNQELy X X +PRKACA PKACA P17612 human ATG16L1 iso3 55054 Q676U5-3 ATG16L1 human S269 460725 RAATKRLsQPAGGLL X X +PRKACA PKACA P17612 human PDE4D iso6 5144 Q08499-6 PDE4D human S126 458388 VHSQRREsFLYRSDs X +PRKACA PKACA P17612 human PTP-PEST 5782 Q05209 PTPN12 human S435 451312 KKLERNLsFEIKKVP X X +PRKACA PKACA P17612 human LXR-alpha 22259 Q9Z0Y9 Nr1h3 mouse S291 479434 QIALLKtsAIEVMLL Hormone_recep X X +PRKACA PKACA P17612 human SYNE1 64009 Q6ZWR6 Syne1 mouse S1366 30310303 SSHERFLsFSsLEsL X +PRKACA PKACA P17612 human LRRK2 120892 Q5S007 LRRK2 human S1443 15785705 FNIKARAsssPVILV Roc X +PRKACA PKACA P17612 human IRS2 384783 P81122 Irs2 mouse S1137 487314 QGGRRRHssEtFSsT X +PRKACA PKACA P17612 human Titin 22138 A2ASS6 Ttn mouse S3993 29618903 TEEGKsLsFPLALEE X +PRKACA PKACA P17612 human MBP 618684 P02687 MBP cow T33 451756 FLPRHRDtGILDSLG Myelin_MBP X +PRKACA PKACA P17612 human PJA2 9867 O43164 PJA2 human T389 18713701 RVItQREtENNQMTs X X +PRKACA PKACA P17612 human GRK7 131890 Q8WTQ7 GRK7 human S36 456355 ELQRRRRsLALPGLQ X +PRKACA PKACA P17612 human HCN4 330953 O70507 Hcn4 mouse S990 15103401 PPRPERPsFMAGAsG X +PRKACA PKACA P17612 human STMN1 3925 P16949 STMN1 human S63 448557 AAEERRksHEAEVLk Stathmin X +PRKACA PKACA P17612 human mucolipin 1 57192 Q9GZU1 MCOLN1 human S559 1233700 kFRRGsGsACsLLCC X X +PRKACA PKACA P17612 human eNOS 24600 Q62600 Nos3 rat S632 448637 WRRKRKEsSNTDSAG Flavodoxin_1 X +PRKACA PKACA P17612 human FAK iso5 396416 Q92063 PTK2 chicken S148 449622 LKPDVRLsRGsIERE X +PRKACA PKACA P17612 human APOBEC3B 9582 Q9UH17 APOBEC3B human T214 1869951800 LVLRRRQtYLCYEVE NAD2 X X +PRKACA PKACA P17612 human PIN1 5300 Q13526 PIN1 human S71 18710000 HsQSRRPssWRQEKI Rotamase X +PRKACA PKACA P17612 human RPT6 5705 P62195 PSMC5 human S120 483970 RVALRNDsyTLHkIL Prot_ATP_ID_OB X X +PRKACA PKACA P17612 human RARA 5914 P10276 RARA human S369 451381 YVRKRRPsRPHMFPK Hormone_recep X X +PRKACA PKACA P17612 human NFkB-p65 309165 Q7TQN4 Rela rat S276 447798 SMQLRRPsDRELSEP RHD_dimer X +PRKACA PKACA P17612 human K8 25626 Q10758 Krt8 rat S43 456883 SsFsRVGsssssFRG Keratin_2_head X +PRKACA PKACA P17612 human IP3R1 25262 P29994 Itpr1 rat S1589 450681 RNAARRDsVLAASRD X +PRKACA PKACA P17612 human AQP2 359 P41181 AQP2 human S256 449854 REVRRRQsVELHsPQ X +PRKACA PKACA P17612 human PEDF 5176 P36955 SERPINF1 human S227 455233 KFDSRKTsLEDFYLD Serpin X +PRKACA PKACA P17612 human CAMKK1 84254 Q8N5S9 CAMKK1 human S74 452115 sLsARkLsLQERPAG X +PRKACA PKACA P17612 human RMP 8725 O94763 URI1 human S372 1028301 AKRKRKNstGsGHsA X X +PRKACA PKACA P17612 human PDE4C iso2 5143 Q08493-2 PDE4C human S13 458390 PHSQRREsFLYRSDS X +PRKACA PKACA P17612 human CTNNB1 1499 P35222 CTNNB1 human S45 447488 GATtTAPsLsGkGNP X X 9565; 9564; 24710; 70034; 19807; 96727; 77605 +PRKACA PKACA P17612 human E2F1 1869 Q01094 E2F1 human S364 449403 PLLSRMGsLRAPVDE X +PRKACA PKACA P17612 human Tau iso8 4137 P10636-8 MAPT human S262 447930 NVKskIGstENLkHQ Tubulin-binding X +PRKACA PKACA P17612 human TNNI3 7137 P19429 TNNI3 human S166 3146609 LGARAKEsLDLRAHL Troponin X +PRKACA PKACA P17612 human Tau 4137 P10636 MAPT human S726 449132 DtsPRHLsNVsstGs X +PRKACA PKACA P17612 human ADRB2 154 P07550 ADRB2 human S346 447911 LLCLRRssLKAyGNG X +PRKACA PKACA P17612 human MAP2 iso3 25595 P15146-3 Map2 rat S435 3558891 VASPRRLsNVsSSGs X +PRKACA PKACA P17612 human ADCY8 11514 P97490 Adcy8 mouse S113 26392110 VFPERSGsGSASGSG X X +PRKACA PKACA P17612 human ATPIF1 93974 Q9UII2 ATP5IF1 human S39 27444486 NVDRGAGsIrEAGGA IATP X +PRKACA PKACA P17612 human TRPV5 56302 Q9NQA5 TRPV5 human T708 4710939 WEILRQNtLGHLNLG X +PRKACA PKACA P17612 human HCN4 330953 O70507 Hcn4 mouse S110 15103406 LGsRGGGsGGAGGGs X +PRKACA PKACA P17612 human RAP1A 5906 P62834 RAP1A human S180 450928 KKKPKKKsCLLL___ X +PRKACA PKACA P17612 human N-CoR1 9611 O75376 NCOR1 human S70 3828921 QQLRRRPsLLsEFHP X +PRKACA PKACA P17612 human PDE11A 50940 Q9HCR9 PDE11A human S117 2243101 GNLQRRAsQKELRKS X +PRKACA PKACA P17612 human KCNJ12 117052 P52188 Kcnj12 rat S425 2150913 ERPYRREsEI_____ X +PRKACA PKACA P17612 human NDR1 11329 Q15208 STK38 human S11 22553320 tGstPCssMsNHtkE X +PRKACA PKACA P17612 human CAMKK1 84254 Q8N5S9 CAMKK1 human S475 486103 RrEErsMsAPGNLLV X +PRKACA PKACA P17612 human TRPC5 7224 Q9UL62 TRPC5 human S796 20834808 GARAKsKsVSFNLGC X +PRKACA PKACA P17612 human PLM 476487 P56513 FXYD1 dog S83 451424 EEGTFRSsIRRLstR X +PRKACA PKACA P17612 human PPAR-alpha 25747 P37230 Ppara rat S163 22342300 CRFHKCLsVGMSHNA zf-C4 X +PRKACA PKACA P17612 human MEF2C 17260 Q8CFN5 Mef2c mouse T20 455602 DERNRQVtFTKRKFG SRF-TF X +PRKACA PKACA P17612 human HDAC4 9759 P56524 HDAC4 human S266 4737976 KVAERRssPLLRRKD X X +PRKACA PKACA P17612 human CAD 101843763 P08955 Cad hamster S1406 451249 GAGGRRLsSFVTKGY MGS X +PRKACA PKACA P17612 human HSL 25330 P15304 Lipe rat S863 448803 LTESMRRsVsEAALA X +PRKACA PKACA P17612 human SYT12 191595 P97610 Syt12 rat S97 473040 GPPSRKGsLsIEDTF X +PRKACA PKACA P17612 human NFL 281348 P02548 NEFL cow S56 451024 SSLSVRRsYsSSSGs Filament_head X +PRKACA PKACA P17612 human SMN 6606 Q16637 SMN1 human S5 2021209 ___MAMssGGsGGGV X X +PRKACA PKACA P17612 human SSB 20823 P32067 Ssb mouse S199 2862901 KNEERKQsKVEAKLK X +PRKACA PKACA P17612 human SIRT1 93759 Q923E4 Sirt1 mouse S434 22568200 LLIVIGSsLKVRPVA SIR2 X +PRKACA PKACA P17612 human PFKL 25741 P30835 Pfkl rat T773 458321 LEHVTRRtLsIDKGF X +PRKACA PKACA P17612 human KSR 8844 Q8IVT5 KSR1 human S888 14993200 PKLNRRLsHPGHFWK X +PRKACA PKACA P17612 human GLI1 2735 P08151 GLI1 human S544 457677 VsLERRSssSSSISS X +PRKACA PKACA P17612 human PPP1R1A P01099 PPP1R1A rabbit T35 447759 QIRRRRPtPATLVLT DARPP-32 X +PRKACA PKACA P17612 human AKAP12 9590 Q02952 AKAP12 human S698 455890 RARRGsssDEEGGPK X X +PRKACA PKACA P17612 human STAR 25557 P97826 Star rat S194 450442 RCTKRRGsTCVLAGM START X +PRKACA PKACA P17612 human ABCC9 25560 Q63563 Abcc9 rat T632 483974 FESCKKHtGVQsKPI X +PRKACA PKACA P17612 human APP 11820 P12023 App mouse S679 480465 DAEFGHDsGFEVRHQ Beta-APP X X +PRKACA PKACA P17612 human BRF1 677 Q07352 ZFP36L1 human S54 2475300 GGFPRRHsVtLPSSk Tis11B_N X X +PRKACA PKACA P17612 human DOCK1 1793 Q14185 DOCK1 human S1250 28698600 HAKLLKWsEDVCVAH DHR-2_Lobe_A X X +PRKACA PKACA P17612 human L-plastin 3936 P13796 LCP1 human S5 450852 ___MARGsVsDEEMM X X +PRKACA PKACA P17612 human MYBPC3 17868 O70468 Mybpc3 mouse S546 4699427 kkLEVyQsIADLAVG I-set X +PRKACA PKACA P17612 human TNNI3 29248 P23693 Tnni3 rat S23 448423 PAPVRRRssANYRAY Troponin-I_N X 4004 +PRKACA PKACA P17612 human HDC 3067 P19113 HDC human S195 1884002000 YASDQAHsSVEKAGL X +PRKACA PKACA P17612 human QSK 23387 Q9Y2K2 SIK3 human S551 468543 GPLGRRAsDGGANIQ X +PRKACA PKACA P17612 human SOX9 6662 P48436 SOX9 human S64 451039 EPDLkKEsEEDkFPV Sox_N X X +PRKACA PKACA P17612 human eNOS 24600 Q62600 Nos3 rat S1176 447884 TSRIRtQsFsLQERQ X 9570 +PRKACA PKACA P17612 human RhoGDI alpha 396 P52565 ARHGDIA human S174 452196 kGMLARGsYsIkSRF Rho_GDI X X +PRKACA PKACA P17612 human AMPKA1 65248 P54645 Prkaa1 rat S496 450431 AtPQRSGsISNYRSC AdenylateSensor X 4185; 4184; 2537 +PRKACA PKACA P17612 human CRYBB2 287011 P02522 CRYBB2 cow S204 451609 QRGAFHPsS______ X +PRKACA PKACA P17612 human Tau 17762 P10637 Mapt mouse S506 447929 GsRsRtPsLPtPPtR X 77348 +PRKACA PKACA P17612 human NEDD4L 23327 Q96PU5 NEDD4L human S448 453440 IRRPRsLssPtVtLS X X 8063 +PRKACA PKACA P17612 human RRAD 56437 O88667 Rrad mouse S26 4700219 ERDRRrGstPWGPAP X +PRKACA PKACA P17612 human HIF1A 3091 Q16665 HIF1A human S809 56589709 VNAPIQGsRNLLQGE HIF-1a_CTAD X +PRKACA PKACA P17612 human DNAJC5 79130 P60905 Dnajc5 rat S10 448129 DQRQRsLsTsGEsLY X +PRKACA PKACA P17612 human AA-NAT 443531 Q29495 AANAT sheep S205 452142 HAALRRNsDR_____ X +PRKACA PKACA P17612 human RGS10 6001 O43665 RGS10 human S176 455907 QTAAKRAsRIYNT__ X +PRKACA PKACA P17612 human Claudin-3 1365 O15551 CLDN3 human T192 455751 PPREKKytAtkVVys X X +PRKACA PKACA P17612 human Tau iso8 4137 P10636-8 MAPT human S324 449328 kVtskCGsLGNIHHk Tubulin-binding X +PRKACA PKACA P17612 human CACNA1D 29716 P27732 Cacna1d rat S517 6062716 RRWGQAIsKsKLRSH X +PRKACA PKACA P17612 human K8 25626 Q10758 Krt8 rat S13 13201904 TQKsYKMsTSGPRAF Keratin_2_head X +PRKACA PKACA P17612 human CACNB1 100009109 P19517 CACNB1 rabbit T205 17552137 VTGTRRPtPPASGNE X +PRKACA PKACA P17612 human SREBP-1 iso1 78968 P56720-1 Srebf1 rat S308 458357 IEKRYRSsINDKIVE HLH X +PRKACA PKACA P17612 human H3F3A 3020 P84243 H3-3A human S10 18545301 tkQTARkstGGkAPR Histone X 9706; 3458 +PRKACA PKACA P17612 human SUN2 25777 Q9UH99 SUN2 human S54 448845 SSNMKRLsPAPQLGP X +PRKACA PKACA P17612 human KEPI 81706 Q8TAE6 PPP1R14C human T73 10296602 RHQQGKVtVkYDRKE PP1_inhibitor X +PRKACA PKACA P17612 human ATG16L1 iso2 55054 Q676U5-2 ATG16L1 human S268 3202215 SRAAtRRsVSSFPVP X X +PRKACA PKACA P17612 human PPP2R5D 21770 Q7TNL5 Ppp2r5d mouse S566 457390 KVLLRRKsELPQDVy X +PRKACA PKACA P17612 human CSK 1445 P41240 CSK human S364 448477 ALREKKFsTKSDVWS PK_Tyr_Ser-Thr X X +PRKACA PKACA P17612 human K8 25626 Q10758 Krt8 rat S24 448538 PRAFssRsFtsGPGA Keratin_2_head X +PRKACA PKACA P17612 human Titin 84015 XP_008773743 Ttn rat T3952 2523800 SDLLSKEtLFSSIPK X +PRKACA PKACA P17612 human ROMK iso2 P35560-2 Kcnj1 rat S200 2461201 RVANLRKsLLIGSHI IRK_C X X +PRKACA PKACA P17612 human Lck 3932 P06239 LCK human S42 447819 tLLIRNGsEVRDPLV X +PRKACA PKACA P17612 human MST3 8428 Q9Y6E0 STK24 human T18 452058 ALNKRRAtLPHPGGS X X +PRKACA PKACA P17612 human MYBPC3 17868 O70468 Mybpc3 mouse S730 1877150012 VETTKDRsVFtVEGA I-set X +PRKACA PKACA P17612 human TPH2 121278 Q8IWU9 TPH2 human S19 470085 YWARRGFsLDSAVPE X X +PRKACA PKACA P17612 human PLM 476487 P56513 FXYD1 dog S88 451425 RSsIRRLstRRR___ X +PRKACA PKACA P17612 human MYBPC3 17868 O70468 Mybpc3 mouse S690 1877150010 VTQGKkAsAGPHPDA I-set X +PRKACA PKACA P17612 human QIK 235344 Q8CFH6 Sik2 mouse S343 2150903 RLKSHRssFPVEQRL X +PRKACA PKACA P17612 human TH 21823 P24529 Th mouse S40 448545 RFIGRRQsLIEDARK TOH_N X 2791 +PRKACA PKACA P17612 human PKACA 282322 P00517 PRKACA cow S326 9768114 FKGPGDTsNFDDYEE X +PRKACA PKACA P17612 human CYP2B6 24300 P00176 Cyp2b1 rat S128 448738 WKALRRFsLATMRDF p450 X +PRKACA PKACA P17612 human CES1D iso2 113902 NP_579829 Ces1d rat S506 3540200 ANFARNGsPNGGGLP COesterase X +PRKACA PKACA P17612 human CAPN2 824 P17655 CAPN2 human S369 451303 DGNWRRGstAGGCRN Calpain_III X +PRKACA PKACA P17612 human ARPP-21 618648 Q7M2N1 ARPP-21 cow S56 1096600 QNQERRKsKSGAGKG X +PRKACA PKACA P17612 human LRRK2 120892 Q5S007 LRRK2 human S935 4725898 NLQRHsNsLGPIFDH X 59576 +PRKACA PKACA P17612 human STAR 25557 P97826 Star rat S276 450443 HLRKRLEsSPASEAQ START X +PRKACA PKACA P17612 human BAD 12015 Q61337 Bad mouse S112 447860 ETRsRHssyPAGtEE Bcl-2_BAD X 9291; 5284; 9296; 5193; 11865; 94223 +PRKACA PKACA P17612 human PGC-1 alpha 19017 O70343 Ppargc1a mouse S194 13861601 SWSNKAKsICQQQkP X X +PRKACA PKACA P17612 human RORA iso2 19883 P51448-2 Rora mouse S99 19009803 MSKKQRDsLYAEVQK X +PRKACA PKACA P17612 human PKACA 282322 P00517 PRKACA cow S260 9768113 SGKVRFPsHFSSDLK Pkinase X +PRKACA PKACA P17612 human TRPA1 8989 O75762 TRPA1 human S317 4752026 ETMLHRAsLFDHHEL Ank_2 X +PRKACA PKACA P17612 human Lu 4059 P50895 BCAM human S621 455912 sGGARGGsGGFGDEC X +PRKACA PKACA P17612 human NPM1 18148 Q61937 Npm1 mouse T95 456130 sLGGFEItPPVVLRL Nucleoplasmin X 3517 +PRKACA PKACA P17612 human MAP2 iso3 25595 P15146-3 Map2 rat T220 2999205 ISSARRTtRSEPIRR X +PRKACA PKACA P17612 human NPM1 18148 Q61937 Npm1 mouse S48 14577038 QLsLRTVsLGAGAkD Nucleoplasmin X +PRKACA PKACA P17612 human CFTR 12638 P26361 Cftr mouse S737 3116903 RLsLVPDsEQGEAAL CFTR_R X +PRKACA PKACA P17612 human CAMKK1 60341 P97756 Camkk1 rat S475 486103 RREERSMsAPGNLLL X +PRKACA PKACA P17612 human AKAP12 9590 Q02952 AKAP12 human S696 480148 kKRARRGsssDEEGG X X +PRKACA PKACA P17612 human CREB iso1 81646 P15337-1 Creb1 rat S133 448228 EILsRRPsYRkILND pKID X X 9187; 9196; 9198; 4095; 14228; 14001; 39561; 80120; 44864; 54960; 95995 +PRKACA PKACA P17612 human GJA1 2697 P17302 GJA1 human S373 459209 RAssRAssRPRPDDL X X +PRKACA PKACA P17612 human H3F3A 3020 P84243 H3-3A human S28 18545302 ATkAARksAPsTGGV Histone X +PRKACA PKACA P17612 human IGFBP1 3484 P08833 IGFBP1 human S126 451658 GsPEsPEstEITEEE X +PRKACA PKACA P17612 human AKAP13 11214 Q12802 AKAP13 human S1565 452184 LsPFRRHsWGPGKNA X X +PRKACA PKACA P17612 human GPLD1 287025 P80109 GPLD1 cow T309 457382 NGFHKNVtAALTKNI X +PRKACA PKACA P17612 human MBP 618684 P02687 MBP cow S109 451768 QGKGrGLsLSRFsWG Myelin_MBP X +PRKACA PKACA P17612 human RAF1 5894 P04049 RAF1 human S259 447741 sQRQRststPNVHMV X 9421; 20011 +PRKACA PKACA P17612 human CARM1 10498 Q86X55 CARM1 human S447 25268707 LIANkRQsYDISIVA X X +PRKACA PKACA P17612 human DAP3 7818 P51398 DAP3 human T186 2226207 DQPLEAstWLkNFkT DAP3 X +PRKACA PKACA P17612 human CPEB3 208922 Q7TN99 Cpeb3 mouse T446 4743577 ssGLssPtRCQNGER X +PRKACA PKACA P17612 human PDE4D iso2 5144 Q08499-2 PDE4D human S54 458388 VHSQRREsFLYRSDS X X +PRKACA PKACA P17612 human RRAD 56437 O88667 Rrad mouse S39 4700224 APPLHRRsMPVDERD X +PRKACA PKACA P17612 human IPO13 116458 Q9JM04 Ipo13 rat S193 15420334 RKGLVRAsLAVECGA Xpo1 X +PRKACA PKACA P17612 human H1E 3008 P10412 H1-4 human S36 456059 GAAkRkAsGPPVsEL X X +PRKACA PKACA P17612 human SREBP-1 78968 P56720 Srebf1 rat S332 458357 IEKRYRssINDKIVE HLH X +PRKACA PKACA P17612 human KCNJ8 25472 Q63664 Kcnj8 rat T234 483977 IQVVKKTtTPEGEVV IRK_C X +PRKACA PKACA P17612 human NLRP3 114548 Q96P20 NLRP3 human S295 57761902 HKIVRKPsRILFLMD NACHT X X +PRKACA PKACA P17612 human GLI3 2737 P10071 GLI3 human S865 15501379 YLSSRRssGISPCFs X X +PRKACA PKACA P17612 human PIN1 5300 Q13526 PIN1 human S16 447772 PGWEkRMsRSSGRVy WW X X +PRKACA PKACA P17612 human TRPA1 8989 O75762 TRPA1 human S428 62873402 CRQGGPGsVNNLLGF Ank_2 X +PRKACA PKACA P17612 human PPP2R5D 21770 Q7TNL5 Ppp2r5d mouse S81 468499 VKKERRQssFPFNLN X +PRKACA PKACA P17612 human GJA1 24392 P08050 Gja1 rat S365 459207 IVDQRPssRAssRAs X X +PRKACA PKACA P17612 human nAChRA4 25590 P09483 Chrna4 rat S472 467263 LIKARSLsVQHVPSS Neur_chan_memb X +PRKACA PKACA P17612 human MYBPC1 iso2 109272 G0YZM8 Mybpc1 mouse S59 21560210 RALERKDsEWsLGES X +PRKACA PKACA P17612 human PKACA 18747 P05132 Prkaca mouse S339 449886 EEEEIRVsINEKCGK X +PRKACA PKACA P17612 human TXA2-R 6915 P21731 TBXA2R human S331 470029 sTRPRsLsLQPQLtQ X +PRKACA PKACA P17612 human APP 351 P05067 APP human S679 480465 DAEFRHDsGYEVHHQ Beta-APP X X +PRKACA PKACA P17612 human TPPP 11076 O94811 TPPP human T92 487538 VIDGRNVtVTDVDIV p25-alpha X +PRKACA PKACA P17612 human STEP 19259 P54830 Ptpn5 mouse S221 448294 GLQERRGsNVSLTLD X 5659 +PRKACA PKACA P17612 human GSK3B 56637 Q9WV60 Gsk3b mouse S9 449111 SGRPRttsFAEsCKP X X 9336; 9331; 9327; 9323; 9322; 9325; 5558; 8566; 79774; 8466; 25462; 14026; 14332; 14310; 14630 +PRKACA PKACA P17612 human HCN4 330953 O70507 Hcn4 mouse S704 15103404 PMMRKKNsILLHKVQ X +PRKACA PKACA P17612 human STAR 25557 P97826 Star rat S56 450440 GQVRRRssLLGSQLE X +PRKACA PKACA P17612 human VDR 7421 P11473 VDR human S182 454433 tPSFSGDsSSSCSDH X +PRKACA PKACA P17612 human 5-LO 240 P09917 ALOX5 human S272 450169 CsLERQLsLEQEVQQ Lipoxygenase X 3748 +PRKACA PKACA P17612 human GLI3 2737 P10071 GLI3 human S849 7998355 NMLNRRDssAStIsS X X +PRKACA PKACA P17612 human DTNB 1838 O60941 DTNB human T424 12203658 GNVtRPPtDLsFNFD X +PRKACA PKACA P17612 human KCNMA1 iso4 16531 Q08460-4 Kcnma1 mouse S701 23013300 GCRRPKMsIYKRMRR X +PRKACA PKACA P17612 human NFL 281348 P02548 NEFL cow S63 2020617 sYsSSSGsLMPsLEs Filament_head X +PRKACA PKACA P17612 human CYP17A1 1586 P05093 CYP17A1 human S258 464643 KEKFRSDsITNMLDT p450 X +PRKACA PKACA P17612 human GFAT 2673 Q06210 GFPT1 human S235 451019 TARTQIGsKFTRWGs X +PRKACA PKACA P17612 human ADRB2 154 P07550 ADRB2 human S261 447908 TGHGLRRssKFcLKE 7tm_1 X +PRKACA PKACA P17612 human SOX9 20682 Q04887 Sox9 mouse S64 451039 EPDLKKEsEEDKFPV Sox_N X +PRKACA PKACA P17612 human TNNI3 511094 P08057 TNNI3 cow S46 450691 KKSKIsAsRKLQLKT X +PRKACA PKACA P17612 human CFTR 1080 P13569 CFTR human S768 455300 LQARRRQsVLNLMtH CFTR_R X X +PRKACA PKACA P17612 human RASGRP2 10235 Q7LDG7 RASGRP2 human S587 10993875 PRPGRrGsRPPEIRE X +PRKACA PKACA P17612 human RIL 30794 P70271 Pdlim4 mouse S119 468635 PAtsRRssVsGIsLE X X +PRKACA PKACA P17612 human CK1A 1452 P48729 CSNK1A1 human S242 11333101 KISEKkMsTPVEVLC Pkinase X +PRKACA PKACA P17612 human SLC4A4 8671 Q9Y6R1 SLC4A4 human S1026 469803 KKKKKKGsLDsDNDD X +PRKACA PKACA P17612 human SNAP-25 6616 P60880 SNAP25 human T29 23939101 ADESLEstRRMLQLV X +PRKACA PKACA P17612 human Tau iso8 4137 P10636-8 MAPT human S316 5204078 VykPVDLskVtskCG Tubulin-binding X +PRKACA PKACA P17612 human ARHGEF2 16800 Q60875 Arhgef2 mouse T114 12473200 sVsLRSKtTTRERPt X +PRKACA PKACA P17612 human DAT 24898 P23977 Slc6a3 rat S7 451136 _MsKsKCsVGPMssV X +PRKACA PKACA P17612 human CCND1 595 P24385 CCND1 human S234 451829 YRLTRFLsRVIkCDP Cyclin_C X +PRKACA PKACA P17612 human Vimentin 7431 P08670 VIM human S72 449026 ssAVrLrssVPGVRL Filament_head X +PRKACA PKACA P17612 human SFRS2 6427 Q01130 SRSF2 human S171 29431801 RSARRsKsksSsVsR X X +PRKACA PKACA P17612 human ARHGAP17 55114 Q68EM7 ARHGAP17 human S702 472376 LsAPRRYsssLsPIQ X +PRKACA PKACA P17612 human HePTP 5778 P35236 PTPN7 human S44 448309 RLQERrGsNVALMLD X X +PRKACA PKACA P17612 human GFAP 2670 P14136 GFAP human S13 449619 ItsAArrsyVSsGEM Filament_head X +PRKACA PKACA P17612 human desmin 1674 P17661 DES human T76 449615 LRAsRLGttRtPssy Filament_head X +PRKACA PKACA P17612 human MYPT1 396020 Q90623 PPP1R12A chicken T850 452075 PREKRRstGVSFWTQ X +PRKACA PKACA P17612 human TXA2-R 6915 P21731 TBXA2R human S324 3061802 RRLQPRLsTRPRsLs X +PRKACA PKACA P17612 human SHIP 16331 Q9ES52 Inpp5d mouse S30 15621800 SRAGKDGsFLVRASE SH2 X +PRKACA PKACA P17612 human IP3R1 25262 P29994 Itpr1 rat S1756 450682 RPSGRREsLTSFGNG X 3760; 8548 +PRKACA PKACA P17612 human Merlin 4771 P35240 NF2 human S518 448282 DTDMKRLsMEIEKEK ERM_C X X 9163; 13281 +PRKACA PKACA P17612 human CACNA1C 100101555 P15381 CACB rabbit S1700 4714250 PEIRRAIsGDLtAEE CAC1F_C X +PRKACA PKACA P17612 human CYP3A4 1576 P08684 CYP3A4 human S116 8084159 GPVGFMksAIsIAED p450 X +PRKACA PKACA P17612 human TXA2-R 6915 P21731 TBXA2R human S329 450989 RLsTRPRsLsLQPQL X +PRKACA PKACA P17612 human RASGRP2 19395 Q9QUG9 Rasgrp2 mouse S586 10993875 PRPGRRSsRPPEIRE X X +PRKACA PKACA P17612 human PIMT 96764 Q96RS0 TGS1 human S656 1881245402 AQRYRLFsRFDDGIk X X +PRKACA PKACA P17612 human perilipin 1 103968 Q8CGN5 Plin1 mouse S517 471365 YsQLRKKs_______ X +PRKACA PKACA P17612 human LC3A 84557 Q9H492 MAP1LC3A human S12 15116600 RPFKQRRsFADRCKE X +PRKACA PKACA P17612 human STAR 6770 P49675 STAR human S195 450442 RCAKRRGsTCVLAGM START X +PRKACA PKACA P17612 human OFD1 8481 O75665 OFD1 human S899 27457630 QREERRQsNLQEVLE X +PRKACA PKACA P17612 human p47phox 653361 P14598 NCF1 human S370 451730 PAVPPRPsADLILNR p47_phox_C X +PRKACA PKACA P17612 human DRP1 114114 O35303 Dnm1l rat S656 483971 VPVARKLsAREQRDC X X 4867; 6319 +PRKACA PKACA P17612 human LXR-alpha 22259 Q9Z0Y9 Nr1h3 mouse S196 469114 SVsPRVssPPQVLPQ X X +PRKACA PKACA P17612 human CDC25B 12531 P30306 Cdc25b mouse S149 7998663 FTIKRFRsLPVRLLE M-inducer_phosp X +PRKACA PKACA P17612 human GFAT iso2 2673 Q06210-2 GFPT1 human S205 451018 AVGTRRGsPLLIGVR X +PRKACA PKACA P17612 human SIK 17691 Q60670 Sik1 mouse T475 15570318 GSTGRRHtLAEVSTH X +PRKACA PKACA P17612 human CASP9 842 P55211 CASP9 human S195 471401 EkLRRRFssLHFMVE Peptidase_C14 X +PRKACA PKACA P17612 human PFKFB3 5209 Q16875 PFKFB3 human S461 448801 NPLMRRNsVtPLAsP X +PRKACA PKACA P17612 human RASGRF1 192213 P28818 Rasgrf1 rat S898 448487 KEIYRRMsLANTGYS X X +PRKACA PKACA P17612 human CDC25B 12531 P30306 Cdc25b mouse S229 470115 AFTQRPSsAPDLMCL M-inducer_phosp X +PRKACA PKACA P17612 human ChREBP 51085 Q9NP71 MLXIPL human S196 451393 KKRLRKPsREDDLLA X +PRKACA PKACA P17612 human PKD1 5310 P98161 PKD1 human S4252 466929 SLQGRRssRAPAGSS X +PRKACA PKACA P17612 human STMN1 3925 P16949 STMN1 human S16 448554 kELEKrAsGQAFELI Stathmin X X 3353 +PRKACA PKACA P17612 human WT1 7490 P19544 WT1 human S393 451121 KTCQRKFsRSDHLKT zf-C2H2 X X +PRKACA PKACA P17612 human PDZK1 5174 Q5T2W1 PDZK1 human S505 456807 MAKERAHstAsHsss X +PRKACA PKACA P17612 human HCN4 330953 O70507 Hcn4 mouse S816 15103409 RHPRRLQsLIPSALG X +PRKACA PKACA P17612 human CACNA1D 29716 P27732 Cacna1d rat T443 6062712 KGYLDWItQAEDIDP X +PRKACA PKACA P17612 human phosducin 20028 Q9QW08 Pdc mouse S71 451205 ERMSRKMsIQEYELI Phosducin X +PRKACA PKACA P17612 human ITGB4 3691 P16144 ITGB4 human S1364 451655 PSGsQRPsVSDDTGC X X +PRKACA PKACA P17612 human SNAPIN 23557 O95295 SNAPIN human S50 448453 HVHAVREsQVELREQ Snapin_Pallidin X +PRKACA PKACA P17612 human TRPV1 7442 Q8NER1 TRPV1 human S502 450016 YFLQRRPsMKTLFVD Ion_trans X +PRKACA PKACA P17612 human TPH1 P09810 Tph1 rat S58 451575 RKSKRRNsEFEIFVD X +PRKACA PKACA P17612 human LRRK2 120892 Q5S007 LRRK2 human S1444 15785707 NIKARAsssPVILVG Roc X +PRKACA PKACA P17612 human NUDE1 iso1 54820 Q9NXR1-1 NDE1 human T131 20609200 LERAKRAtIMSLEDF X X +PRKACA PKACA P17612 human CAPN1 823 P07384 CAPN1 human S418 785120101 GDREsGCsFVLALMQ Calpain_III X +PRKACA PKACA P17612 human Tau iso8 4137 P10636-8 MAPT human S293 449327 NVQskCGsKDNIkHV Tubulin-binding X +PRKACA PKACA P17612 human NDRG1 10397 Q92597 NDRG1 human T366 454246 GtRsRsHtsEGAHLD X +PRKACA PKACA P17612 human Tau 4137 P10636 MAPT human S579 447930 NVKSKIGstENLKHQ Tubulin-binding X +PRKACA PKACA P17612 human PSMD11 69077 Q8BG32 Psmd11 mouse S14 468525 VEFQRAQsLLSTDRE RPN6_N X +PRKACA PKACA P17612 human AKAP12 9590 Q02952 AKAP12 human S627 476343 KKRVRRPsEsDKEDE WSK X +PRKACA PKACA P17612 human MEKK2 26405 Q61083 Map3k2 mouse S153 3216819 AERKKRLsVVGPPNR X X +PRKACA PKACA P17612 human MBP 618684 P02687 MBP cow S131 451769 FGYGGRAsDYKSAHK Myelin_MBP X +PRKACA PKACA P17612 human Tau 4137 P10636 MAPT human S531 447929 GsRsRtPsLPtPPtR X 77348 +PRKACA PKACA P17612 human ABCB1 5243 P08183 ABCB1 human S683 455364 QAQDRKLstKEALDE X +PRKACA PKACA P17612 human BAD 572 Q92934 BAD human S99 447862 PFrGrsRsAPPNLWA Bcl-2_BAD X 9295; 5286; 4366 +PRKACA PKACA P17612 human RPS19 6223 P39019 RPS19 human S59 7113803 WFytrAAsTARHLYL Ribosomal_S19e X +PRKACA PKACA P17612 human DLC1 50768 Q9R0Z9 Dlc1 mouse S550 467752 DIPERRDsGVGAsLt X X +PRKACA PKACA P17612 human TRIM71 636931 Q1PSW8 Trim71 mouse S3 18914372 _____MAsFPETDFQ X +PRKACA PKACA P17612 human AKAP9 10142 Q99996 AKAP9 human S43 456204 QkKKRKTsSsKHDVS X +PRKACA PKACA P17612 human SLC14A2 54302 Q62668 Slc14a2 rat S486 2813501 TVFPRRKsVFHIEWS X +PRKACA PKACA P17612 human En-2 13799 P09066 En2 mouse S267 452011 LTEQRRQsLAQELSL Homeodomain X X +PRKACA PKACA P17612 human AurA 6790 O14965 AURKA human T288 448784 APSsRRttLCGtLDy Pkinase X 3079; 2914; 13464; 8525 +PRKACA PKACA P17612 human INVS 27130 Q9Y283 INVS human T795 1384540900 CAPQKRRtQELrGGR X +PRKACA PKACA P17612 human POLD3 10714 Q15054 POLD3 human S458 3196808 GkANRQVsITGFFQR CDC27 X X +PRKACA PKACA P17612 human PPP1R1A 5502 Q13522 PPP1R1A human T75 471085 PRQRKKMtRItPTMK DARPP-32 X +PRKACA PKACA P17612 human RASGRP2 19395 Q9QUG9 Rasgrp2 mouse S116 468584 QEGNRRHssLIDIES X X +PRKACA PKACA P17612 human Tau 4137 P10636 MAPT human S673 449104 RVQSKIGsLDNITHV Tubulin-binding X +PRKACA PKACA P17612 human NMDAR2B 2904 Q13224 GRIN2B human S1166 481156 sDDFKRDsVsGGGPC NMDAR2_C X +PRKACA PKACA P17612 human SOX9 6662 P48436 SOX9 human S181 456981 YQPRRRKsVKNGQAE X X +PRKACA PKACA P17612 human CACNA1D 29716 P27732 Cacna1d rat T49 6062717 QPNssKQtVLsWQAA X +PRKACA PKACA P17612 human TPI1 iso3 7167 P60174-3 TPI1 human S58 465652 KMNGRKQsLGELIGT TIM X X +PRKACA PKACA P17612 human Kv1.4 3739 P22459 KCNA4 human T601 456509 LKKFRSStSSSLGDK X +PRKACA PKACA P17612 human KCNN2 3781 Q9H2S1 KCNN2 human S135 460691 FEKRKRLsDYALIFG SK_channel X +PRKACA PKACA P17612 human MYPT1 396020 Q90623 PPP1R12A chicken S694 451998 QARQSRRstQGVTLT X +PRKACA PKACA P17612 human VASP 22323 P70460 Vasp mouse S153 448379 EHMERRVsNAGGPPA X 3111; 84519 +PRKACA PKACA P17612 human RYR1 20190 E9PZQ0 Ryr1 mouse S2844 451818 KKKTRkIsQTAQtYD X +PRKACA PKACA P17612 human APOBEC3G 60489 Q9HC16 APOBEC3G human T32 5044101 PILSRRNtVWLCYEV NAD2 X X +PRKACA PKACA P17612 human DLC1 50768 Q9R0Z9 Dlc1 mouse S432 15500000 KELKRRNssSSLSSR X X +PRKACA PKACA P17612 human Titin 84015 XP_008773743 Ttn rat S3897 27842904 LRTEEGKsLsFPLAL X +PRKACA PKACA P17612 human ROMK 24521 P35560 Kcnj1 rat S219 2461201 RVANLRKsLLIGSHI IRK_C X +PRKACA PKACA P17612 human EGR2 13654 P08152 Egr2 mouse S349 1875113000 EGCDRRFsRSDELTR zf-C2H2 X +PRKACA PKACA P17612 human mucolipin 1 57192 Q9GZU1 MCOLN1 human S557 1233701 SGkFRRGsGsACsLL X X +PRKACA PKACA P17612 human THOP1 64517 P24155 Thop1 rat S644 448213 VGMDYRTsILRPGGS Peptidase_M3 X +PRKACA PKACA P17612 human TNNI3 21954 P48787 Tnni3 mouse S24 448424 APVRRRssANyRAYA Troponin-I_N X +PRKACA PKACA P17612 human GPKOW 27238 Q92917 GPKOW human S27 10405008 sFGFtRtsARRRLAD X X +PRKACA PKACA P17612 human GMF-beta 2764 P60983 GMFB human S83 451485 QHDDGRVsyPLCFIF Cofilin_ADF X +PRKACA PKACA P17612 human RAP1GAP 5909 P47736 RAP1GAP human S490 15405645 KsPtRKKsGPFGsRR X X +PRKACA PKACA P17612 human separase 9700 Q14674 ESPL1 human S1501 447668 TDNWRKMsFEILRGs X +PRKACA PKACA P17612 human CDK16 5127 Q00536 CDK16 human S153 453451 sRRLRRVsLsEIGFG X X +PRKACA PKACA P17612 human CYP2E1 1571 P05181 CYP2E1 human S256 23940001 RVkEHHQsLDPNCPR p450 X +PRKACA PKACA P17612 human GRK1 6011 Q15835 GRK1 human S21 456353 AFIAARGsFDGSSSQ X +PRKACA PKACA P17612 human KCNK9 51305 Q9NPC2 KCNK9 human S373 18609100 RLMKRRKsV______ X X +PRKACA PKACA P17612 human CAMKK2 10645 Q96RR4 CAMKK2 human S100 4755871 HLsGRkLsLQERSQG X +PRKACA PKACA P17612 human Tau iso8 4137 P10636-8 MAPT human S409 449132 DtsPRHLsNVsstGs X +PRKACA PKACA P17612 human AVPR2 554 P30518 AVPR2 human S255 2853107 RRGRRTGsPGEGAHV 7tm_1 X +PRKACA PKACA P17612 human CAD 790 P27708 CAD human S1406 451249 GAGGRRLssFVtkGY MGS X X +PRKACA PKACA P17612 human CAPN1 823 P07384 CAPN1 human S256 785120103 GCsIDIssVLDMEAI Peptidase_C2 X +PRKACA PKACA P17612 human CPEB3 208922 Q7TN99 Cpeb3 mouse S299 25734913 PLKKPFssNVIAPPK X +PRKACA PKACA P17612 human GIRK1 3760 P48549 KCNJ3 human S385 4706226 NSKERHNsVECLDGL X X +PRKACA PKACA P17612 human GNMT 25134 P13255 Gnmt rat S10 460706 DSVYRTRsLGVAAEG X +PRKACA PKACA P17612 human GJA1 2697 P17302 GJA1 human S369 459208 RPssRAssRAssRPR X X +PRKACA PKACA P17612 human NKX2-1 25628 P23441 Nkx2-1 rat S337 3081708 DLAHHAAsPAALQGQ X +PRKACA PKACA P17612 human NFkB-p65 5970 Q04206 RELA human S42 25302155 RYkCEGRsAGsIPGE RHD_DNA_bind X +PRKACA PKACA P17612 human nAChRA4 25590 P09483 Chrna4 rat S491 467264 EDGIRCRsRSIQYCV Neur_chan_memb X +PRKACA PKACA P17612 human MYBPC3 4607 Q14896 MYBPC3 human S275 471079 LSAFRRtsLAGGGRR X +PRKACA PKACA P17612 human ARPP-19 10776 P56211 ARPP19 human S104 477874 DLPQRkPsLVAskLA Endosulfine X +PRKACA PKACA P17612 human RRAD 56437 O88667 Rrad mouse S301 4700229 AFRAKsKsCHDLSVL X +PRKACA PKACA P17612 human MBP 618684 P02687 MBP cow S10 456424 QKRPsQRsKYLASAs X +PRKACA PKACA P17612 human GFAP 2670 P14136 GFAP human S8 449618 MERRRItsAArrsyV Filament_head X +PRKACA PKACA P17612 human SHIP 16331 Q9ES52 Inpp5d mouse T1092 15621807 tPRIRsFtCSSSAEG X +PRKACA PKACA P17612 human CA9 768 Q16790 CA9 human T443 21691604 RRQHRRGtKGGVsyR X X +PRKACA PKACA P17612 human DDB1 1642 Q16531 DDB1 human S645 7321234 LRtFRSLstTNVFAC X +PRKACA PKACA P17612 human GSK3A 2931 P49840 GSK3A human S21 448584 sGrARtssFAEPGGG X X 9337; 9316; 9331; 5090; 9327; 8452; 8566 +PRKACA PKACA P17612 human PDE5A 8654 O76074 PDE5A human S102 448178 GTPTRKIsAsEFDRP X +PRKACA PKACA P17612 human CBX3 11335 Q13185 CBX3 human S93 457001 kDGtKRksLsDsEsD X X 2600 +PRKACA PKACA P17612 human PKACA 282322 P00517 PRKACA cow T198 448459 RVKGRTWtLCGTPEY Pkinase X 4781; 5661 +PRKACA PKACA P17612 human WEE1B 381759 Q66JT0 Wee2 mouse S15 456697 QGLNKKLsFSFCEED X +PRKACA PKACA P17612 human SHIP 16331 Q9ES52 Inpp5d mouse S775 15621805 EGENEEGsEGELVVR X +PRKACA PKACA P17612 human CACNA1D 29716 P27732 Cacna1d rat S929 6062718 GsAFFILsKTNPIRV X +PRKACA PKACA P17612 human HSP27 3315 P04792 HSPB1 human S82 448403 RALsRQLssGVsEIr X 2406; 2401; 9709; 11892; 64293 +PRKACA PKACA P17612 human HCN4 330953 O70507 Hcn4 mouse S996 15103410 PsFMAGAsGGASPVA X +PRKACA PKACA P17612 human NFkB-p105 81736 Q63369 Nfkb1 rat S336 449967 FVQLRRKsDLETSEP RHD_dimer X +PRKACA PKACA P17612 human smMLCK 396445 P11799 MYLK chicken S1749 466361 RAIGRLSsMAMISGM X +PRKACA PKACA P17612 human HCN4 330953 O70507 Hcn4 mouse T1056 3827242 QVPQRRGtPPLtPGR X +PRKACA PKACA P17612 human HNF4 alpha 15378 P49698 Hnf4a mouse S143 458369 RIStRRssYEDSsLP X +PRKACA PKACA P17612 human SREBP-1 6720 P36956 SREBF1 human S338 458357 IEkRYRSsINDkIIE HLH X X +PRKACA PKACA P17612 human Kv11.1 3757 Q12809 KCNH2 human T895 4974500 KLsFRRRtDKDTEQP X X +PRKACA PKACA P17612 human nAChRD P02718 CHNRD torpedo S382 3300801 DLKLRRSsSVGYISK Neur_chan_memb X +PRKACA PKACA P17612 human ERM 2119 P41161 ETV5 human S367 451201 PPYQRRGsLQLWQFL X X +PRKACA PKACA P17612 human HCN4 330953 O70507 Hcn4 mouse S1139 15103400 VTLPRKtssGsLPPP X +PRKACA PKACA P17612 human GluR1 50592 P19490 Gria1 rat S863 448566 TSTLPRNsGAGASGG X X 8084 +PRKACA PKACA P17612 human CACNA1D 29716 P27732 Cacna1d rat S46 6062721 PTSQPNssKQtVLsW X +PRKACA PKACA P17612 human FRAT1 10023 Q92837 FRAT1 human S188 471366 RLQQRRGsQPETRTG GSK-3_bind X X +PRKACA PKACA P17612 human HIF1A 3091 Q16665 HIF1A human T700 56589704 VALsQRTtVPEEELN X +PRKACA PKACA P17612 human VASP 7408 P50552 VASP human S239 448380 GAKLRKVsKQEEASG X X 3114; 37565 +PRKACA PKACA P17612 human RAP1B 5908 P61224 RAP1B human S179 451799 PGkARKKsscQLL__ X X +PRKACA PKACA P17612 human HCN4 330953 O70507 Hcn4 mouse S903 15103407 FHKALGGsLSSSDSP X +PRKACA PKACA P17612 human ROMK 56379 O88335 Kcnj1 mouse S25 449605 RQRARLVsKDGRCNI IRK X +PRKACA PKACA P17612 human KIF3A 16568 P28741 Kif3a mouse S689 454304 KMGRRKRsAKPEtVI X +PRKACA PKACA P17612 human RAF1 5894 P04049 RAF1 human S621 447746 PKINRsAsEPsLHRA X +PRKACA PKACA P17612 human smMLCK 100009143 P29294 MYLK rabbit S1005 455821 GLSGRKSsTGSPTsP X X +PRKACA PKACA P17612 human NIPP-1 282319 Q28147 PPP1R8 cow S199 451284 PKRKRKNsRVTFsED X +PRKACA PKACA P17612 human LATS1 16798 Q8BYR2 Lats1 mouse S908 457594 HQRCLAHsLVGTPNY Pkinase X 9157 +PRKACA PKACA P17612 human TPH1 7166 P17752 TPH1 human S58 451575 RKSKRRNsEFEIFVD X +PRKACA PKACA P17612 human PPP2R5D 5528 Q14738 PPP2R5D human S573 457390 KVLLRRksELPQDVy X +PRKACA PKACA P17612 human eNOS 4846 P29474 NOS3 human S615 448656 SYKIRFNsISCSDPL Flavodoxin_1 X +PRKACA PKACA P17612 human SEC14L2 23541 O76054 SEC14L2 human S289 455526 VQISRGSsHQVEyEI X +PRKACA PKACA P17612 human FHIP2B 64760 Q86V87 FHIP2B human S325 40642200 GISWRLPsAPSDEAS RAI16-like X +PRKACA PKACA P17612 human HSP70 3303 P0DMV8 HSPA1B human S418 15403914 TALIkrNstIPTkQT HSP70 X +PRKACA PKACA P17612 human LRRK2 120892 Q5S007 LRRK2 human S910 4725893 LVKKKsNsIsVGEFY X +PRKACA PKACA P17612 human SRI 109552 Q6P069 Sri mouse S178 469979 DsFRRRDsGQQGVVN X +PRKACA PKACA P17612 human CYP2E1 1571 P05181 CYP2E1 human S129 455561 WKDIRRFsLttLRNY p450 X +PRKACA PKACA P17612 human KCNN2 54262 P70604 Kcnn2 rat S465 460687 QAIHQLRsVKMEQRK CaMBD X +PRKACA PKACA P17612 human PIMT 96764 Q96RS0 TGS1 human S851 1881245404 DLIRRPAsET_____ X +PRKACA PKACA P17612 human STMN1 16765 P54227 Stmn1 mouse S63 448557 AAEERRKsHEAEVLK Stathmin X +PRKACA PKACA P17612 human CTNNB1 1499 P35222 CTNNB1 human S179 23096710 AVMVHQLskKEAsRH X +PRKACA PKACA P17612 human CUL5 8065 Q93034 CUL5 human S730 963800 MkMRKKIsNAQLQTE Cullin_Nedd8 X +PRKACA PKACA P17612 human LRP6 4040 O75581 LRP6 human T1548 21009100 yAPsRRMtSVATAkG X +PRKACA PKACA P17612 human UBE3A iso2 7337 Q05086-2 UBE3A human T485 48891100 MYSERRItVLYsLVQ X +PRKACA PKACA P17612 human HSP90B 3326 P08238 HSP90AB1 human T89 18495101 RtLtLVDtGIGMtkA HATPase_c X +PRKACA PKACA P17612 human TVB5 P04213 TVB5 mouse S78 25573800 GYKASRPsQENFSLI V-set X +PRKACA PKACA P17612 human CACNB2 100009277 P54288 CAB2 rabbit S322 2024725 ERSNTRSsLAEVQSE Guanylate_kin X +PRKACA PKACA P17612 human nAChRG P02714 CHRNG torpedo S370 3300800 KPQPRRRsSFGIMIK Neur_chan_memb X +PRKACA PKACA P17612 human BAD 12015 Q61337 Bad mouse S155 447863 GRELRRMsDEFEGsF Bcl-2_BAD X X 9297 +PRKACA PKACA P17612 human GJA1 2697 P17302 GJA1 human S365 459207 IVDQRPssRAssRAs X +PRKACA PKACA P17612 human SHP-2 iso1 5781 Q06124-1 PTPN11 human S189 27458516 GGGERFDsLTDLVEH SH2 X +PRKACA PKACA P17612 human MARK2 2011 Q7KZI7 MARK2 human S409 3245780 NPKQRRFsDQAAGPA X X +PRKACA PKACA P17612 human PIK3CG 5294 P48736 PIK3CG human T1024 20506703 YLALRHHtNLLIILF PI3_PI4_kinase X +PRKACA PKACA P17612 human GLI3 2737 P10071 GLI3 human S1006 15501397 GHGVRRAsDPVRTGS X X +PRKACA PKACA P17612 human SYNE1 64009 Q6ZWR6 Syne1 mouse S1389 30310302 EFSKRTEsIATQAEN X +PRKACA PKACA P17612 human PRKD1 5587 Q15139 PRKD1 human S421 4960330 KHTKRKSstVMKEGW X +PRKACA PKACA P17612 human NFkB-p65 5970 Q04206 RELA human S45 25302163 CEGRsAGsIPGERST RHD_DNA_bind X +PRKACA PKACA P17612 human NHE3 24784 P26433 Slc9a3 rat S605 450900 SLEQRRRsIRDTEDM X +PRKACA PKACA P17612 human KDELR1 10945 P24390 KDELR1 human S209 455669 VLKGKKLsLPA____ X X +PRKACA PKACA P17612 human NOXA1 10811 Q86UR1 NOXA1 human S461 990301 VPAGPRMsGAPGRLP X X +PRKACA PKACA P17612 human CTBP2 1488 P56545 CTBP2 human S164 2089803 REGTRVQsVEQIREV 2-Hacid_dh_C; 2-Hacid_dh X +PRKACA PKACA P17612 human HER2 2064 P04626 ERBB2 human T686 451817 QQKIRKYtMRRLLQE X X 88583 +PRKACA PKACA P17612 human Vimentin 22352 P20152 Vim mouse S51 449416 LRPstsRsLysssPG Filament_head X +PRKACA PKACA P17612 human CYP3A4 1576 P08684 CYP3A4 human S478 5938006 TQIPLKLsLGGLLQP p450 X +PRKACA PKACA P17612 human ULK2 9706 Q8IYT8 ULK2 human S1027 41294001 CSIERRLsALCHSTA DUF3543 X +PRKACA PKACA P17612 human LRP1 4035 Q07954 LRP1 human S4520 450168 GGHGsRHsLAsTDEk X +PRKACA PKACA P17612 human Kv4.2 3751 Q9NZV8 KCND2 human S552 450462 VSGSHQGsIQELSTI X +PRKACA PKACA P17612 human BNIP3 664 Q12983 BNIP3 human T188 41388500 IYIGRRLttststF_ BNIP3 X +PRKACA PKACA P17612 human PKAR2B 5577 P31323 PRKAR2B human S114 452036 NRFTRRAsVCAEAyN X +PRKACA PKACA P17612 human CACNA1D 29716 P27732 Cacna1d rat S1743 6062700 VNSDRREsLQQTNTT CAC1F_C X X +PRKACA PKACA P17612 human GABRB1 14400 P50571 Gabrb1 mouse S410 10296601 QyRKPLssREGFGRG Neur_chan_memb X +PRKACA PKACA P17612 human RHOA 387 P61586 RHOA human S188 449035 ARRGKKKsGCLVL__ X X +PRKACA PKACA P17612 human CTBP1 1487 Q13363 CTBP1 human T144 2089802 LNLYRRAtWLHQALR 2-Hacid_dh_C; 2-Hacid_dh X +PRKACA PKACA P17612 human CRF-R1 iso2 1394 P34998-2 CRHR1 human S301 450262 LMTKLRAsTTSETIQ 7tm_2 X +PRKACA PKACA P17612 human TNNI3 511094 P08057 TNNI3 cow S24 448423 PPPVRRRssANYRAY Troponin-I_N X +PRKACA PKACA P17612 human HSP27 3315 P04792 HSPB1 human S78 448402 PAysRALsRQLssGV X 2405 +PRKACA PKACA P17612 human CACNB2 116600 Q8VGC3 Cacnb2 rat S529 1868239900 KKSQHRSssATHQNH X X +PRKACA PKACA P17612 human CACNA1C iso5 12288 Q0PCR6 Cacna1c mouse S1927 455278 ASLGRRAsFHLECLK CAC1F_C X +PRKACA PKACA P17612 human BAD 572 Q92934 BAD human S75 447860 EIRsRHssyPAGtED Bcl-2_BAD X X 9291; 5284; 9296; 5193; 11865; 94223 +PRKACA PKACA P17612 human NFL 281348 P02548 NEFL cow S42 457402 TARSAYSsYSAPVSS Filament_head X +PRKACA PKACA P17612 human PLM 5348 O00168 FXYD1 human S83 451424 EEGtFRssIRRLstR X X +PRKACA PKACA P17612 human TRPC6 22068 Q61143 Trpc6 mouse T69 470868 RLTHRRQtILREKGR X +PRKACA PKACA P17612 human RAP1B 5908 P61224 RAP1B human S180 22689703 GkARKKsscQLL___ X +PRKACA PKACA P17612 human SCN5A 6331 Q14524 SCN5A human S528 451569 KPRssrGsIFtFRRR Na_trans_cytopl X X +PRKACA PKACA P17612 human profilin 1 5216 P07737 PFN1 human S72 15413723 tLGGQkCsVIRDsLL Profilin X +PRKACA PKACA P17612 human SLC24A6 80024 Q6J4K2 SLC8B1 human S258 50596805 YQRQRRGsLFCPMPV X X +PRKACA PKACA P17612 human GRK2 282682 P21146 GRK2 cow S685 447726 VPLIQRGsANGL___ X +PRKACA PKACA P17612 human USP20 10868 Q9Y2K6 USP20 human S333 7323248 RMKDRKFsWGQQRtN X +PRKACA PKACA P17612 human ABCC9 20928 P70170 Abcc9 mouse T633 483974 FESCKKHtGVQSKPI X +PRKACA PKACA P17612 human Spinophilin 84686 O35274 Ppp1r9b rat S94 448728 SDRGVRLsLPRAssL X X +PRKACA PKACA P17612 human ADRB2 154 P07550 ADRB2 human S262 447909 GHGLRRssKFcLKEH 7tm_1 X +PRKACA PKACA P17612 human TNF-R1 7132 P19438 TNFRSF1A human T411 1868023606 LAtWRRRtPRREAtL Death X +PRKACA PKACA P17612 human eNOS 18127 P70313 Nos3 mouse S1176 447884 TSRIRtQsFsLQERQ X 9571; 9570 +PRKACA PKACA P17612 human PDE4A 5141 P27815 PDE4A human S145 458389 ATSQRREsFLYRSDs X +PRKACA PKACA P17612 human PFKM 100345647 P00511 PFKM rabbit S775 458322 EHISRKRsGEATV__ X +PRKACA PKACA P17612 human CACNA1D 29716 P27732 Cacna1d rat S2152 6062707 AStLLNGsVCPRANG CAC1F_C X +PRKACA PKACA P17612 human NDR1 11329 Q15208 STK38 human S10 22553319 MtGstPCssMsNHtk X +PRKACA PKACA P17612 human PKACA 282322 P00517 PRKACA cow T49 4271878 DQFERIKtLGTGsFG Pkinase X +PRKACA PKACA P17612 human ABCB1 5243 P08183 ABCB1 human S667 455363 SsLIRKRsTRRsVRG X +PRKACA PKACA P17612 human CAMKK1 60341 P97756 Camkk1 rat S74 452115 SLSARKFsLQERPAG X +PRKACA PKACA P17612 human HDAC8 55869 Q9BY41 HDAC8 human S39 450667 AKIPKRAsMVHsLIE Hist_deacetyl X X +PRKACA PKACA P17612 human ITCH 16396 Q8C863 Itch mouse T425 470111 VNHNTRItQWEDPRS WW X +PRKACA PKACA P17612 human MAP2 4133 P11137 MAP2 human S1710 456809 HVTsKCGsLKNIRHR Tubulin-binding X X +PRKACA PKACA P17612 human TNNI3 7137 P19429 TNNI3 human S39 3146608 EPHAKKKskIsAsRK X +PRKACA PKACA P17612 human SNAP-25 6616 P60880 SNAP25 human S187 448668 RIMEKADsNKTRIDE X +PRKACA PKACA P17612 human GJA8 395846 P36381 GJA8 chicken S395 9824606 KASSRARsDDLTV__ X X +PRKACA PKACA P17612 human ABCC9 20928 P70170 Abcc9 mouse S1387 483973 HTLRsRLsIILQDPI ABC_tran X X +PRKACA PKACA P17612 human eNOS 4846 P29474 NOS3 human S1177 447884 TSRIRtQsFsLQERQ X 9571; 9570 +PRKACA PKACA P17612 human GJD2 14617 O54851 Gjd2 mouse S315 471389 PNFGRTQsSDSAYV_ X +PRKACA PKACA P17612 human Survivin 332 O15392 BIRC5 human S20 485776 FLkDHRIstFkNWPF BIR X X +PRKACA PKACA P17612 human Kv7.2 iso4 3785 O43526-4 KCNQ2 human S438 481666 QTVRRsPsADQSLED KCNQ_channel X +PRKACA PKACA P17612 human STIM1 6786 Q13586 STIM1 human T389 37049500 KIKKKRNtLFGtFHV SOAR X +PRKACA PKACA P17612 human UFD1L 7353 Q92890 UFD1 human S229 15428799 ELGFRAFsGsGNRLD X X +PRKACA PKACA P17612 human CREB 1385 P16220 CREB1 human S119 448228 EILsRRPsyRkILND pKID X 9187; 9196; 9198; 4095; 14228; 14001; 39561; 80120; 44864; 54960; 95995 +PRKACA PKACA P17612 human ARHGEF7 114559 O55043 Arhgef7 rat S516 455215 RKPERKPsDEEFAVR RhoGEF67_u2 X X +PRKACA PKACA P17612 human Oct4 5460 Q01860 POU5F1 human S288 22830416 RRQKGKRsssDyAQR X +PRKACA PKACA P17612 human GFAP 2670 P14136 GFAP human T7 449617 _MERRRItsAArrsy Filament_head X +PRKACA PKACA P17612 human KCNN2 3781 Q9H2S1 KCNN2 human S569 460690 sRRRrsssTAPPtSS X X +PRKACA PKACA P17612 human APPL 26060 Q9UKG1 APPL1 human S410 25802100 sFQQRHEsLRPAAGQ X +PRKACA PKACA P17612 human HCN4 330953 O70507 Hcn4 mouse S1142 4699522 PRKtssGsLPPPLSL X +PRKACA PKACA P17612 human Vimentin 280955 P48616 VIM cow S7 455449 _MSTRSVsSSSYRRM Filament_head X +PRKACA PKACA P17612 human CUTL1 1523 P39880 CUX1 human S1215 460700 AYMKRRHssVsDSQP X +PRKACA PKACA P17612 human ABCC9 25560 Q63563 Abcc9 rat S636 41608700 KKHtGVQsKPINRKQ X +PRKACA PKACA P17612 human SEPT7 989 Q16181 SEPTIN7 human T198 56658862 PLIAkADtLTPEECQ Septin X +PRKACA PKACA P17612 human SHIP 16331 Q9ES52 Inpp5d mouse S441 15621804 QGKTRDDsADYIPHD Exo_endo_phos X X +PRKACA PKACA P17612 human DTNB 1838 O60941 DTNB human T11 27100600 ESGNKRktMAEKRQL X +PRKACA PKACA P17612 human RYR2 6262 Q92736 RYR2 human S2031 455603 TIRGRLLsLVEKVTy X X +PRKACA PKACA P17612 human ADAM22 11496 Q9R1V6 Adam22 mouse S855 469109 RFRPRsNsTEtLsPA X +PRKACA PKACA P17612 human PKACA 282322 P00517 PRKACA cow S11 469998 AAAAKKGsEQEsVKE X +PRKACA PKACA P17612 human GIRK4 3762 P48544 KCNJ5 human T199 27523602 QPKKRAEtLMFsNNA X +PRKACA PKACA P17612 human NEDD4L 23327 Q96PU5 NEDD4L human T367 453439 AGRARsstVtGGEEP X +PRKACA PKACA P17612 human CIITA 4261 P33076 CIITA human S834 448443 QELPGRLsFLGtRLT X +PRKACA PKACA P17612 human CK1A 1452 P48729 CSNK1A1 human S218 11333100 LMYFNRTsLPWQGLk Pkinase X +PRKACA PKACA P17612 human TRPM8 79054 Q7Z2W7 TRPM8 human S9 12570903 SFRAARLsMRNRRND X +PRKACA PKACA P17612 human PKD2L1 9033 Q9P0L9 PKD2L1 human S682 394791406 EIEKLGRsIVssPQG X +PRKACA PKACA P17612 human MYBPC3 17868 O70468 Mybpc3 mouse S282 471080 AGAGRRtsDsHEDAG X +PRKACA PKACA P17612 human MFN2 9927 O95140 MFN2 human S442 4746700 AEEIRRLsVLVDDYQ X +PRKACA PKACA P17612 human CACNA1C 12288 Q01815 Cacna1c mouse S1897 455278 ASLGRRAsFHLECLK CAC1F_C X +PRKACA PKACA P17612 human CACNA1D 29716 P27732 Cacna1d rat S1964 4771088 PPSHRRSsFNFECLR CAC1F_C X X +PRKACA PKACA P17612 human KCNK18 332396 Q6VV64 Kcnk18 mouse S264 2712200 RPVERSNsCPELVLG X +PRKACA PKACA P17612 human HNF4 alpha 25735 P22449 Hnf4a rat S143 458369 RISTRRssYEDSSLP X +PRKACA PKACA P17612 human GSK3B 2932 P49841 GSK3B human S9 449111 SGRPRttsFAEsCkP X X 9336; 9331; 9327; 9323; 9322; 9325; 5558; 8566; 79774; 8466; 25462; 14026; 14332; 14310; 14630 +PRKACA PKACA P17612 human CACNA1D 29716 P27732 Cacna1d rat S1788 6062704 HNHHNHNsIGKQVPt CAC1F_C X +PRKACA PKACA P17612 human PAH 5053 P00439 PAH human S16 449074 PGLGRKLsDFGQETS X +PRKACA PKACA P17612 human LXR-alpha 22259 Q9Z0Y9 Nr1h3 mouse S195 479432 TSVsPRVssPPQVLP X X +PRKACA PKACA P17612 human SCN5A 6331 Q14524 SCN5A human S516 4719558 LsLTrGLsRTsMKPR Na_trans_cytopl X +PRKACA PKACA P17612 human PDE4D iso7 5144 Q08499-7 PDE4D human S126 458388 VHSQRREsFLYRSDS X +PRKACA PKACA P17612 human TRPC6 22068 Q61143 Trpc6 mouse S28 22280200 AGTRRNEsQDYLLMD X +PRKACA PKACA P17612 human emerin 2010 P50402 EMD human S49 457523 EtQRRRLsPPsssAA X +PRKACA PKACA P17612 human PDE3B 5140 Q13370 PDE3B human S318 449873 CkIFRRPsLPCIsRE X +PRKACA PKACA P17612 human MYPT1 396020 Q90623 PPP1R12A chicken T695 448587 ARQSRRstQGVTLTD X 5163 +PRKACA PKACA P17612 human MAZ 100008693 O97600 MAZ rabbit S187 449094 ALEKKRKsKGPYICA X +PRKACA PKACA P17612 human HCN4 330953 O70507 Hcn4 mouse S1097 4699507 sPHssGEsVAAFSLY X +PRKACA PKACA P17612 human GRK7 131890 Q8WTQ7 GRK7 human S23 456354 YLQARKPsDCDSKEL X +PRKACA PKACA P17612 human NIPP-1 282319 Q28147 PPP1R8 cow S178 451282 TAHNKRIsTLTIEEG X +PRKACA PKACA P17612 human PLM 5348 O00168 FXYD1 human S88 451425 RssIRRLstRRR___ X X +PRKACA PKACA P17612 human GIRK1 50599 P63251 Kcnj3 rat S401 10769100 DISTKLPsKLQKItG X +PRKACA PKACA P17612 human NFkB-p65 19697 Q04207 Rela mouse S276 447798 SMQLRRPsDRELSEP RHD_dimer X +PRKACA PKACA P17612 human NPM1 18148 Q61937 Npm1 mouse S88 4169620 MsVQPTVsLGGFEIt Nucleoplasmin X +PRKACA PKACA P17612 human K8 25626 Q10758 Krt8 rat S426 13201905 YAGGLSSsYGGLTsP X +PRKACA PKACA P17612 human AID 57379 Q9GZX7 AICDA human T27 471423 WAKGRREtYLCYVVK APOBEC2 X X +PRKACA PKACA P17612 human CETN2 1069 P41208 CETN2 human S170 448199 LRIMkKTsLY_____ X +PRKACA PKACA P17612 human GLI1 2735 P08151 GLI1 human S640 457679 AGVTRRAsDPAQAAD X +PRKACA PKACA P17612 human GLI3 2737 P10071 GLI3 human S907 15501388 TDAsRRSsEASQSDG X X +PRKACA PKACA P17612 human WT1 7490 P19544 WT1 human S365 451117 KDCERRFsRSDQLKR zf-C2H2 X X +PRKACA PKACA P17612 human TGM2 21817 P21981 Tgm2 mouse S216 467223 RDCSRRSsPIyVGRV X +PRKACA PKACA P17612 human HSPB8 26353 Q9UJY1 HSPB8 human S57 2201401 DWALPRLsSAWPGtL X +PRKACA PKACA P17612 human CPEB3 208922 Q7TN99 Cpeb3 mouse S419 54003201 YGRRRGRssLFPFED X X +PRKACA PKACA P17612 human GluR1 2890 P42261 GRIA1 human S863 448566 TStLPRNsGAGASSG X 8084 +PRKACA PKACA P17612 human K8 25626 Q10758 Krt8 rat S9 484004 sVRVTQKsYKMsTSG Keratin_2_head X +PRKACA PKACA P17612 human PDE3B 5140 Q13370 PDE3B human S296 475067 IRPRRRssCVsLGEt X +PRKACA PKACA P17612 human PDE3A 5139 Q14432 PDE3A human S428 456821 IPKRLRRsLPPGLLR X +PRKACA PKACA P17612 human PLM 58971 O08589 Fxyd1 rat S83 451424 EEGtFRSsIRRLstR X +PRKACA PKACA P17612 human smMLCK 396445 P11799 MYLK chicken S1762 455821 GMsGRKAsGssPTsP X +PRKACA PKACA P17612 human HCN4 330953 O70507 Hcn4 mouse S99 15103402 DCRRFRGsLAsLGsR X +PRKACA PKACA P17612 human CCND1 595 P24385 CCND1 human S90 451827 NYLDRFLsLEPVkkS Cyclin_N X +PRKACA PKACA P17612 human SMN 6606 Q16637 SMN1 human S8 4269865 MAMssGGsGGGVPEQ X X +PRKACA PKACA P17612 human PGC-1 alpha 19017 O70343 Ppargc1a mouse S241 13861602 KCASKKKsHTQPQSQ X X +PRKACA PKACA P17612 human MYPT1 116670 Q10728 Ppp1r12a rat S696 451998 QARQSRRstQGVTLT X +PRKACA PKACA P17612 human SHIP 16331 Q9ES52 Inpp5d mouse S260 4778392 PQVPGEAsPITMVAK X +PRKACA PKACA P17612 human Tau iso8 4137 P10636-8 MAPT human S214 447929 GsRsRtPsLPtPPtR X 77348 +PRKACA PKACA P17612 human SHIP 16331 Q9ES52 Inpp5d mouse S162 15621802 APEVTRLsLSETLFQ X +PRKACA PKACA P17612 human CAPN1 823 P07384 CAPN1 human S415 785120100 DDyGDREsGCsFVLA Calpain_III X +PRKACA PKACA P17612 human HCN4 330953 O70507 Hcn4 mouse T1138 15103405 HVTLPRKtssGsLPP X +PRKACA PKACA P17612 human ABCB1 5243 P08183 ABCB1 human S671 455365 RKRsTRRsVRGsQAQ X +PRKACA PKACA P17612 human SOX11 20666 Q7M6Y2 Sox11 mouse S133 1290433400 TDPAAKPsAGQsPDK X X +PRKACA PKACA P17612 human Titin 22138 A2ASS6 Ttn mouse S3991 27842904 LRTEEGKsLsFPLAL X +PRKACA PKACA P17612 human PLM 58971 O08589 Fxyd1 rat S88 451425 RSsIRRLstRRR___ X X +PRKACA PKACA P17612 human GJA1 2697 P17302 GJA1 human S364 450183 AIVDQRPssRAssRA X +PRKACA PKACA P17612 human PTP-PEST 5782 Q05209 PTPN12 human S39 451311 FMRLRRLstKYRTEK X X +PRKACA PKACA P17612 human PDE8A 5151 O60658 PDE8A human S359 18261095 HKDRRKGsLDVkAVA X X +PRKACA PKACA P17612 human Tau iso8 4137 P10636-8 MAPT human S356 449104 rVQskIGsLDNItHV Tubulin-binding X +PRKACA PKACA P17612 human dematin 2039 Q08495 DMTN human S403 450255 NELKKKAsLF_____ VHP X +PRKACA PKACA P17612 human SNAP-25 6616 P60880 SNAP25 human T138 449875 GGFIRRVtNDARENE SNAP-25 X +PRKACA PKACA P17612 human smMLCK 396445 P11799 MYLK chicken S149 17555039 PPVEHRPsIWGESPP X +PRKACA PKACA P17612 human BNIP3 12176 O55003 Bnip3 mouse T181 41388500 IYIGRRLtTSTSTF_ BNIP3 X +PRKACA PKACA P17612 human PKACA 5566 P17612 PRKACA human T198 448459 RVKGRtWtLCGtPEy Pkinase X 4781; 5661 +PRKACA PKACA P17612 human RAF1 5894 P04049 RAF1 human S43 447744 FGyQRRAsDDGKLtD X +PRKACA PKACA P17612 human eNOS 4846 P29474 NOS3 human S633 448637 WRRKRKEssNtDsAG Flavodoxin_1 X +PRKACA PKACA P17612 human MEF2D 17261 Q63943 Mef2d mouse S190 2246701 QPALQRNsVsPGLPQ X X +PRKACA PKACA P17612 human Kv11.1 3757 Q12809 KCNH2 human S283 4696779 CASVRRAssADDIEA X X +PRKACA PKACA P17612 human STAR 101844174 P70114 Star hamster S194 450442 RCAKRRGsTCVLAGI START X +PRKACA PKACA P17612 human DJ-1 11315 Q99497 PARK7 human T154 2566111 EkDGLILtSRGPGTS DJ-1_PfpI X X +PRKACA PKACA P17612 human CACNA1D 29716 P27732 Cacna1d rat T863 6062709 ANsDNKVtIDDYQEE X +PRKACA PKACA P17612 human DISC1 244667 Q811T9 Disc1 mouse S710 18942700 QLQEAGSsPHAEDEE X X +PRKACA PKACA P17612 human HIF1A 3091 Q16665 HIF1A human T455 31887953 LAMsPLPtAEtPkPL X +PRKACA PKACA P17612 human LKB1 6794 Q15831 STK11 human S428 448147 SSkIRRLsACkQQ__ X 3482 +PRKACA PKACA P17612 human DISC1 27185 Q9NRI5 DISC1 human S713 18942700 QLQEARGsLSVEDER X X +PRKACA PKACA P17612 human TRPV5 Q9XSM3 Trpv5 rabbit T709 4710939 WEILRRNtLGHLNLG X X +PRKACA PKACA P17612 human PDE10A iso2 10846 Q9Y233-2 PDE10A human T16 478273 AScFRRLtECFLSPS X X +PRKACA PKACA P17612 human MYBPC1 iso2 109272 G0YZM8 Mybpc1 mouse S62 21560209 ERKDsEWsLGESPAG X +PRKACA PKACA P17612 human DARPP-32 84152 Q9UD71 PPP1R1B human T34 448047 MIrRRRPtPAMLFRL DARPP-32 X 12438 +PRKACA PKACA P17612 human PPP1R3A 100009140 Q00756 RG1 rabbit S67 449321 SSGGRRVsFADNFGF X +PRKACA PKACA P17612 human mGluR5 108071 Q3UVX5 Grm5 mouse S870 25745197 NLWKRrGssGEtLrY X X +PRKACA PKACA P17612 human Lasp-1 3927 Q14847 LASP1 human S146 448836 MEPERRDsQDGssyR X X +PRKACA PKACA P17612 human ETV1 2115 P50549 ETV1 human S191 3059602 HRFRRQLsEPCNSFP ETS_PEA3_N X X +PRKACA PKACA P17612 human CAPN2 824 P17655 CAPN2 human T370 451304 GNWRRGstAGGCRNY Calpain_III X X +PRKACA PKACA P17612 human ROMK iso2 P35560-2 Kcnj1 rat S294 2461200 ATCQVRTsYVPEEVL IRK_C X X +PRKACA PKACA P17612 human TNF-R1 7132 P19438 TNFRSF1A human T417 11077252 RtPRREAtLELLGRV Death X +PRKACA PKACA P17612 human PPP1R16B 282091 Q95N27 PPP1R16B cow S337 486245 SSLsRRTsSAGSRGK X +PRKACA PKACA P17612 human Fyn 2534 P06241 FYN human S21 1983273 LTEERDGsLNQssGy X X +PRKACA PKACA P17612 human GAD67 2571 Q99259 GAD1 human T91 451699 RDARFRRtETDFSNL X +PRKACA PKACA P17612 human phosducin 25343 P20942 Pdc rat S73 451205 ERMSRKMsIQEYELI Phosducin X +PRKACA PKACA P17612 human PDE3B 5140 Q13370 PDE3B human S73 475068 PQQPRRCsPFCRARL X +PRKACA PKACA P17612 human SF2 6426 Q07955 SRSF1 human S119 27106000 yGPPsRRsENRVVVS X X +PRKACA PKACA P17612 human GJA1 24392 P08050 Gja1 rat S368 447813 QRPssRAssRAssRP X X 3511; 52559 +PRKACA PKACA P17612 human Titin 84015 XP_008773743 Ttn rat S3899 29618903 TEEGKsLsFPLALEE X +PRKACA PKACA P17612 human CREB iso1 81646 P15337-1 Creb1 rat S129 450092 QKRREILsRRPsYRk pKID X +PRKACA PKACA P17612 human GLI1 2735 P08151 GLI1 human S560 457678 YTVSRRSsLASPFPP X +PRKACA PKACA P17612 human PGC-1 alpha 19017 O70343 Ppargc1a mouse T256 13861600 HAQAKPTtLSLPLTP X X +PRKACA PKACA P17612 human BAD 572 Q92934 BAD human S118 447863 GRELRRMsDEFVDsF Bcl-2_BAD X 9297 +PRKACA PKACA P17612 human TH 7054 P07101 TH human S40 1876194200 GQGAPGPsLTGSPWP TOH_N X +PRKACA PKACA P17612 human PJA2 9867 O43164 PJA2 human S342 18713700 RHEAkQRsVQRWREA X X +PRKACA PKACA P17612 human SHANK3 59312 Q9JLU4 Shank3 rat S685 3844913 PPPKRAPsTTLTLRS X X +PRKACA PKACA P17612 human Ezrin 7430 P15311 EZR human S66 458400 LkLDKkVsAQEVRkE FERM_N X X +PRKACA PKACA P17612 human Raptor 57521 Q8N122 RPTOR human S791 1868515108 IDKMRRAssYSsLNS X +PRKACA PKACA P17612 human Titin 7273 Q8WZ42 TTN human S4065 2523800 RDLLSKEsLLsGIPE X +PRKACA PKACA P17612 human NR5A2 2494 O00482 NR5A2 human S510 456465 LPEIRAIsMQAEEYL Hormone_recep X +PRKACA PKACA P17612 human Kv7.5 56479 Q9NR82 KCNQ5 human S88 4780184 GKQGARMsLLGKPLS X +PRKACA PKACA P17612 human TPPP 11076 O94811 TPPP human S159 487537 sGVtKAIssPtVSRL p25-alpha X +PRKACA PKACA P17612 human CACNA1D 29716 P27732 Cacna1d rat T1795 6062703 sIGKQVPtSTNANLN CAC1F_C X +PRKACA PKACA P17612 human TFAM 7019 Q00059 TFAM human S55 18016712 SCPKkPVssYLRFsk HMG_box X X +PRKACA PKACA P17612 human HSF1 3297 Q00613 HSF1 human S320 3849409 AsPGRPssVDtLLsP Vert_HS_TF X X +PRKACA PKACA P17612 human PSMD2 5708 Q13200 PSMD2 human S361 487471 ENNrFGGsGsQVDsA X +PRKACA PKACA P17612 human KLHL3 26249 Q9UH77 KLHL3 human S433 36440206 PMNTRRSsVGVGVVE Kelch_1 X X +PRKACA PKACA P17612 human ARHGEF2 16800 Q60875 Arhgef2 mouse S885 451365 PLDPRRRsLPAGDAL X 14143 +PRKACA PKACA P17612 human Titin 7273 Q8WZ42 TTN human S4185 5474103 IQQGAKtsLQEEMDs X +PRKACA PKACA P17612 human PPP1R1A 5502 Q13522 PPP1R1A human S67 447758 LKSTLAMsPRQRKKM DARPP-32 X +PRKACA PKACA P17612 human Vimentin 7431 P08670 VIM human S73 449025 sAVrLrssVPGVRLL Filament_head X +PRKACA PKACA P17612 human SHP-2 iso1 5781 Q06124-1 PTPN11 human T73 40407604 YGGEKFAtLAELVQY SH2 X +PRKACA PKACA P17612 human NCX1 29715 Q01728 Slc8a1 rat T731 18575503 VDKLIKKtNLALVVG X +PRKACA PKACA P17612 human DLX3 1747 O60479 DLX3 human S10 25736077 GSFDRKLsSILTDIS X +PRKACA PKACA P17612 human TRPV4 59341 Q9HBA0 TRPV4 human S824 4777181 LRRDRWssVVPRVVE X +PRKACA PKACA P17612 human PAPD4 167153 Q6PIY7 TENT2 human S116 50785745 LsGERRYsMPPLFHT X +PRKACA PKACA P17612 human TH 25085 P04177 Th rat S153 3302701 LSSVRRVsDDVRSAR X +PRKACA PKACA P17612 human PPP2R5D 21770 Q7TNL5 Ppp2r5d mouse S53 457388 PssNKRPsNStPPPT X +PRKACA PKACA P17612 human PFKFB1 24638 P07953 Pfkfb1 rat S33 456206 VLQRRRGsSIPQFTN 6PF2K X +PRKACA PKACA P17612 human NFkB-p105 18033 P25799 Nfkb1 mouse S326 22771100 VNITKPAsVFVQLRR RHD_dimer X +PRKACA PKACA P17612 human NSFL1C 55968 Q9UNZ2 NSFL1C human S176 468328 AGEkRQHssQDVHVV X +PRKACA PKACA P17612 human RIMS1 iso7 116837 Q99NE5-7 Rims1 mouse S413 450481 ARHERRHsDVALPHT X +PRKACA PKACA P17612 human Stargazin 84347 Q71RJ2 Cacng2 rat T321 451273 NTANRRTtPV_____ X +PRKACA PKACA P17612 human ITPKA 81677 P17105 Itpka rat S119 4763186 LQQPRRLsTSSLSST X X +PRKACA PKACA P17612 human CSF2RB 12983 P26955 Csf2rb mouse S603 448463 LGPPQSHsLPDLPDQ X +PRKACA PKACA P17612 human Spinophilin 84686 O35274 Ppp1r9b rat S177 448727 LLRQERAsLQDRKLD X X +PRKACA PKACA P17612 human VASP 22323 P70460 Vasp mouse S235 448380 GAKLRKVsKQEEASG X 3114; 37565 +PRKACA PKACA P17612 human TFAM 7019 Q00059 TFAM human S61 27530800 VssYLRFskEQLPIF HMG_box X +PRKACA PKACA P17612 human Kv1.1 3736 Q09470 KCNA1 human S446 451079 SDLSRRssStMSKSE X X +PRKACA PKACA P17612 human CACNA1C 775 Q13936 CACNA1C human S1981 455278 ASLGRRAsFHLECLK X +PRKACA PKACA P17612 human PDE3A 5139 Q14432 PDE3A human S312 456900 SKSHRRTsLPCIPRE X X +PRKACA PKACA P17612 human CD44 960 P16070 CD44 human S697 465669 AVEDRkPsGLNGEAs X X +PRKACA PKACA P17612 human RYR2 689560 B0LPN4 Ryr2 rat S2798 448848 yNRTRRIsQTsQVsI X X +PRKACA PKACA P17612 human DUOX1 53905 Q9NRD9 DUOX1 human S1217 6370300 SHHFRRRsFRGFWLT Ferric_reduct X X +PRKACA PKACA P17612 human Myb 396244 P01103 MYB chicken S116 448757 KYGPKRWsVIAKHLK Myb_DNA-binding X X +PRKACA PKACA P17612 human KCNJ8 25472 Q63664 Kcnj8 rat S385 483976 NsLRKRNsMRRNNsM X +PRKACA PKACA P17612 human RARA 5914 P10276 RARA human S219 13373501 NSSEQRVsLDIDLWD X +PRKACA PKACA P17612 human RCAN1 iso2 1827 P53805-2 RCAN1 human S93 25687504 AQTLHIGsSHLAPPN Calcipressin X +PRKACA PKACA P17612 human PHF2 5253 O75151 PHF2 human S757 20936500 NARVKKEsGSSAAGI X X +PRKACA PKACA P17612 human BRF1 677 Q07352 ZFP36L1 human S334 7997096 LPIFsRLsIsDD___ X X +PRKACA PKACA P17612 human DAP3 7818 P51398 DAP3 human S220 2226205 REstEkGsPLGEVVE DAP3 X +PRKACA PKACA P17612 human HSL 3991 Q05469 LIPE human S853 448803 IAEPMRRsVsEAALA X 4139 +PRKACA PKACA P17612 human DACT1 51339 Q9NYF0 DACT1 human S237 18159801 GAVCRSLsTPQFNSL Dapper X +PRKACA PKACA P17612 human Kv4.2 Q63881 Kcnd2 rat S552 450462 VSGsHRGsVQELSTI X +PRKACA PKACA P17612 human ANXA1 301 P04083 ANXA1 human T216 447973 AGERRkGtDVNVFNT Annexin X +PRKACA PKACA P17612 human SMN 6606 Q16637 SMN1 human S4 7446258 ____MAMssGGsGGG X X +PRKACA PKACA P17612 human CFTR 1080 P13569 CFTR human S660 449979 FSAERRNsILTETLH CFTR_R X X +PRKACA PKACA P17612 human RGS14 114705 O08773 Rgs14 rat T494 5862703 GSTGKRQtCDIEGLV X +PRKACA PKACA P17612 human Kv1.2 100009479 NP_001076191 LOC100009479 rabbit S449 1818102 PDLKKSRsASTISKS X X +PRKACA PKACA P17612 human CACNB2 116600 Q8VGC3 Cacnb2 rat S530 451474 KSQHRSssATHQNHR X X +PRKACA PKACA P17612 human Tau iso8 4137 P10636-8 MAPT human T245 487534 sAKsRLQtAPVPMPD Tubulin-binding X +PRKACA PKACA P17612 human PPM1B 5495 O75688 PPM1B human S195 27461503 MIQRVNGsLAVSRAL PP2C X X +PRKACA PKACA P17612 human HIF1A 3091 Q16665 HIF1A human S692 56589702 PRsPNVLsVALsQRT X +PRKACA PKACA P17612 human Tau iso2 4137 P10636-2 MAPT human S267 449104 RVQSKIGsLDNITHV Tubulin-binding X +PRKACA PKACA P17612 human ataxin-1 6310 P54253 ATXN1 human S775 449110 AtRKRRWsAPESRKL X X +PRKACA PKACA P17612 human CAD 790 P27708 CAD human S1859 451247 PPRIhRAsDPGLPAE X X 12662; 67235; 70307 +PRKACA PKACA P17612 human ATP1A1 24211 P06685 Atp1a1 rat S943 451649 ICKTRRNsVFQQGMK Cation_ATPase_C X +PRKACA PKACA P17612 human GJD2 14617 O54851 Gjd2 mouse S306 471388 NKDLPRVsVPNFGRT X +PRKACA PKACA P17612 human Oct7 5454 P20265 POU3F2 human S360 486486 RKRKKRTsIEVSVKG Homeodomain X +PRKACA PKACA P17612 human PSMD11 5717 O00231 PSMD11 human S14 468525 VEFQrAQsLLSTDrE RPN6_N X X +PRKACA PKACA P17612 human GJA1 24392 P08050 Gja1 rat S369 459208 RPssRAssRAssRPR X X +PRKACA PKACA P17612 human PDE3A 5139 Q14432 PDE3A human S438 456984 PGLLRRVsstWtttt X X +PRKACA PKACA P17612 human HLAA 3105 P04439 HLA-A human S337 11418301 VMWRRKSsDRkGGsy MHC_I_C X +PRKACA PKACA P17612 human QSK 23387 Q9Y2K2 SIK3 human T469 480134 YLSMRRHtVGVADPR X +PRKACA PKACA P17612 human KRas iso2 3845 P01116-2 KRAS human S181 459210 GKKKKkKskTkCVIM X +PRKACA PKACA P17612 human MEF2D 17261 Q63943 Mef2d mouse S121 2246700 EDKYRRAsEELDGLF HJURP_C X X +PRKACA PKACA P17612 human PKACA 282322 P00517 PRKACA cow S213 9768110 LAPEIILsKGYNKAV Pkinase X +PRKACA PKACA P17612 human ATP1A1 476 P05023 ATP1A1 human S943 451649 ICKTRRNsVFQQGMk Cation_ATPase_C X +PRKACA PKACA P17612 human NFkB-p65 5970 Q04206 RELA human S276 447798 sMQLRRPsDRELsEP RHD_dimer X X +PRKACA PKACA P17612 human TH 25085 P04177 Th rat S40 448545 RFIGRRQsLIEDARK TOH_N X 2791 +PRKACA PKACA P17612 human CPEB3 208922 Q7TN99 Cpeb3 mouse S443 2658904 QALssGLssPtRCQN X +PRKACA PKACA P17612 human CACNA1C 24239 P22002 Cacna1c rat S1927 455278 ASLGRRAsFHLECLK CAC1F_C X X +PRKACA PKACA P17612 human K8 25626 Q10758 Krt8 rat S417 13201906 SIHTKTTsGYAGGLS X +PRKACA PKACA P17612 human ABCA1 19 O95477 ABCA1 human S2054 455498 GGNkRKLsTAMALIG ABC_tran X +PRKACA PKACA P17612 human TRPA1 8989 O75762 TRPA1 human S86 62873401 MEKITRDsSLEVLHE Ank_2 X +PRKACA PKACA P17612 human ARFGEF1 10565 Q9Y6D6 ARFGEF1 human S883 459627 EIAGkKIsMKETKEL X +PRKACA PKACA P17612 human RYR2 20191 E9Q401 Ryr2 mouse S2807 448848 YNRTRRIsQtsQVsI X X +PRKACA PKACA P17612 human FLNA 2316 P21333 FLNA human S2152 451357 tRRRRAPsVANVGsH Filamin X X 4761 +PRKACA PKACA P17612 human phosducin 25343 P20942 Pdc rat S54 454888 KEILRQMsSPQSRDD Phosducin X +PRKACA PKACA P17612 human ITCH 16396 Q8C863 Itch mouse S411 470110 GWEkRTDsNGRVYFV WW X +PRKACA PKACA P17612 human FOXO1A 2308 Q12778 FOXO1 human S276 1253812002 RAAKKkAsLQSGQEG X X +PRKACA PKACA P17612 human TNNI3 21954 P48787 Tnni3 mouse S23 448423 PAPVRRRssANyRAY Troponin-I_N X +PRKACA PKACA P17612 human CDC37 11140 Q16543 CDC37 human S97 1214257700 QLRkEERsWEQkLEE CDC37_N X X +PRKACA PKACA P17612 human TH iso2 7054 P07101-2 TH human S67 448545 RFIGRRQsLIEDARK TOH_N X 2791 +PRKACA PKACA P17612 human GluR6 54257 P42260 Grik2 rat S715 451343 FMSSRRQsVLVKSNE Lig_chan X +PRKACA PKACA P17612 human NDRG1 10397 Q92597 NDRG1 human S330 452879 LMRsRtAsGssVtsL X 3506; 11899 +PRKACA PKACA P17612 human C/EBP-beta 1051 P17676 CEBPB human S288 452156 NNIAVRKsRDKAKMR bZIP_2 X +PRKACA PKACA P17612 human RGS14 114705 O08773 Rgs14 rat S258 10343403 NSALRREsQGSLNSS X +PRKACA PKACA P17612 human Src 6714 P12931 SRC human S17 448231 DAsQRRRsLEPAENV X X 5473; 12432 +PRKACA PKACA P17612 human RASGRP2 19395 Q9QUG9 Rasgrp2 mouse S554 4781198 ECrRRAQsVsLEGSA X X +PRKACA PKACA P17612 human Merlin 4771 P35240 NF2 human S10 1720901 GAIASRMsFSsLkRK X +PRKACA PKACA P17612 human TPR 7175 P12270 TPR human S2108 34424908 IQMTRrQsVGrGLQL X X +PRKACA PKACA P17612 human ADD1 118 P35611 ADD1 human S726 449829 KKKFRtPsFLKKsKK X +PRKACA PKACA P17612 human IQGAP2 10788 Q13576 IQGAP2 human T716 18964300 EyMHRRQtFIDNTDS X X +PRKACA PKACA P17612 human HCN4 330953 O70507 Hcn4 mouse S1036 15103403 RASGSHGsLLLPPAS X +PRKACA PKACA P17612 human MYBPC3 17868 O70468 Mybpc3 mouse S302 471081 sLLKKRDsFRRDskL X +PRKACA PKACA P17612 human SMN 6606 Q16637 SMN1 human T85 20503415 NKsQKkNtAAsLQQW SMN X +PRKACA PKACA P17612 human TFAM 7019 Q00059 TFAM human S160 27530802 GkPKRPRsAYNVyVA HMG_box_2 X +PRKACA PKACA P17612 human MBP 618684 P02687 MBP cow S54 451832 RGAPKRGsGKDGHHA Myelin_MBP X +PRKACA PKACA P17612 human S6 29304 P62755 Rps6 rat S236 448093 AKRRRLssLRAstsK X 5006; 4856; 4857; 4858; 4851; 4803; 2211; 3945; 3985; 5316; 4854; 8520; 48319; 40643; 9865; 38573; 14733; 27036; 34411; 62016; 62788; 81736; 97935; 99457; 15448 +PRKACA PKACA P17612 human TAL1 6886 P17542 TAL1 human S172 4704529 NRVKRRPsPYEMEIT X X +PRKACA PKACA P17612 human Vimentin 7431 P08670 VIM human S39 451766 ttstrtysLGsALrP Filament_head X 13614 +PRKACA PKACA P17612 human RASGRP2 361714 P0C643 Rasgrp2 rat S116 468584 QEGNRRHsSLIDIES X +PRKACA PKACA P17612 human PKD2 5311 Q13563 PKD2 human S829 4696848 HSSRRRGsISSGVSY X X +PRKACA PKACA P17612 human ADAM22 11496 Q9R1V6 Adam22 mouse S832 469108 NGRPRsNsWQGNMGG X +PRKACA PKACA P17612 human DNAJC5 80331 Q9H3Z4 DNAJC5 human S10 448129 DQRQRsLstsGEsLy X +PRKACA PKACA P17612 human TRPC6 89823 Q99N78 Trpc6 rat T69 470868 RLTHRRQtVLREKGR X +PRKACA PKACA P17612 human CYP3A4 1576 P08684 CYP3A4 human S119 22553300 GFMksAIsIAEDEEW p450 X +PRKACA PKACA P17612 human Moesin 4478 P26038 MSN human T558 447706 LGRDKyKtLRQIRQG ERM_C X 3141; 3726; 32600 +PRKACA PKACA P17612 human HLAA 3105 P04439 HLA-A human S343 11418300 SsDRkGGsytQAAss MHC_I_C X +PRKACA PKACA P17612 human SREBP-1 78968 P56720 Srebf1 rat S331 7996200 AIEKRYRssINDKIV HLH X +PRKACA PKACA P17612 human p47phox 653361 P14598 NCF1 human S328 449404 QDAYRRNsVRFLQQR NECFESHC X +PRKACA PKACA P17612 human GFAT 2673 Q06210 GFPT1 human S205 451018 AVGtRRGsPLLIGVR X +PRKACA PKACA P17612 human DAP3 7818 P51398 DAP3 human S31 2226208 MGTQARQsIAAHLDN X +PRKACA PKACA P17612 human CPEB3 208922 Q7TN99 Cpeb3 mouse S298 25734909 sPLKKPFssNVIAPP X +PRKACA PKACA P17612 human SNAP-25 6616 P60880 SNAP25 human S28 23939100 LADESLEstRRMLQL X +PRKACA PKACA P17612 human ETV1 2115 P50549 ETV1 human S334 3059601 PTYQRRGsLQLWQFL X X +PRKACA PKACA P17612 human KCNN2 3781 Q9H2S1 KCNN2 human S567 460688 SSsRRRrsssTAPPt X X +PRKACA PKACA P17612 human STAR 101844174 P70114 Star hamster S56 450440 SQVRRRssLLGSQLE X +PRKACA PKACA P17612 human MAP2 4133 P11137 MAP2 human S1782 456422 GAEIItQsPGRssVA X X +PRKACA PKACA P17612 human IP3R2 16439 Q9Z329 Itpr2 mouse S937 468039 QMVLSRGsIFPVSVP X X +PRKACA PKACA P17612 human NMDAR2C 24411 Q00961 Grin2c rat S1231 463822 SCTWRRVssLEsEV_ X +PRKACA PKACA P17612 human p53 7157 P04637 TP53 human S378 447534 skkGQstsRHkkLMF X +PRKACA PKACA P17612 human IRS2 384783 P81122 Irs2 mouse S1138 453435 GGRRRHssEtFSsTt X 2385 +PRKACA PKACA P17612 human GCM1 8521 Q9NP62 GCM1 human S269 18788303 LYEKRKLsSSRTYsS X X +PRKACA PKACA P17612 human EMSY 56946 Q7Z589 EMSY human T207 1210942 KPRKRRRtNsssssP X X +PRKACA PKACA P17612 human CAPN1 823 P07384 CAPN1 human S255 785120102 LGCsIDIssVLDMEA Peptidase_C2 X +PRKACA PKACA P17612 human LAMTOR4 389541 Q0VGL1 LAMTOR4 human S67 1868827201 NVPFkRLsVVFGEHT X X +PRKACA PKACA P17612 human DYNLRB1 83658 Q9NP97 DYNLRB1 human S73 27523608 LtFLRIRsKkNEIMV Robl_LC7 X X +PRKACA PKACA P17612 human AMPKA1 105787 Q5EG47 Prkaa1 mouse S184 3195152 DGEFLRtsCGsPNYA Pkinase X X +PRKACA PKACA P17612 human hnRNP I iso1 5725 P26599-1 PTBP1 human S16 450288 AVGtkRGsDELFstC X X +PRKACA PKACA P17612 human SFRS2 6427 Q01130 SRSF2 human S121 6422897 GyGrRSRsPRRRRRs X X +PRKACA PKACA P17612 human ArgBP2 8470 O94875 SORBS2 human S259 467482 DFRKRRKsEPAVGPP X +PRKACA PKACA P17612 human MBP 618684 P02687 MBP cow S160 456582 FKLGGRDsRSGsPMA Myelin_MBP X +PRKACA PKACA P17612 human G-alpha 13 10672 Q14344 GNA13 human T203 448723 ILLARRPtkGIHEYD G-alpha X +PRKACA PKACA P17612 human FOXO1A 56458 Q9R1E0 Foxo1 mouse S150 1253812000 AGQPRKTsSSRRNAW X +PRKACA PKACA P17612 human PRKD1 18760 Q62101 Prkd1 mouse S203 449896 GVRRRRLsNVsLTGL X X +PRKACA PKACA P17612 human ITGA4 3676 P13612 ITGA4 human S1021 469620 QEENRRDsWsyINSk X X +PRKACA PKACA P17612 human PKACA 5566 P17612 PRKACA human S339 449886 EEEEIRVsINEkCGk X X +PRKACA PKACA P17612 human STMN2 84510 P21818 Stmn2 rat S97 455607 AAEGRRKsQEAQVLK Stathmin X +PRKACA PKACA P17612 human SHIP 16331 Q9ES52 Inpp5d mouse S38 15621801 FLVRASEsIPRAYAL SH2 X +PRKACA PKACA P17612 human MYPT1 116670 Q10728 Ppp1r12a rat T697 448587 ARQSRRstQGVTLTD X 5163 +PRKACA PKACA P17612 human SGK1 6446 O00141 SGK1 human T369 448432 DLINKkItPPFNPNV X +PRKACA PKACA P17612 human MYPT1 396020 Q90623 PPP1R12A chicken S849 451999 RPREKRRstGVSFWT X +PRKACA PKACA P17612 human Pyk2 2185 Q14289 PTK2B human S778 2192705 HNVFKRHsMREEDFI X X +PRKACA PKACA P17612 human CYP2E1 1571 P05181 CYP2E1 human T373 23940002 SNLPHEAtRDtIFrG p450 X +PRKACA PKACA P17612 human TH 7054 P07101 TH human S71 448545 RFIGRRQsLIEDARK TOH_N X 2791 +PRKACA PKACA P17612 human PDE11A 50940 Q9HCR9 PDE11A human S162 2243100 RALLRKAssLPPTTA X +PRKACA PKACA P17612 human 5-LO 240 P09917 ALOX5 human S524 452140 GMRGRKSsGFPkSVK Lipoxygenase X X +PRKACA PKACA P17612 human PARP1 142 P09874 PARP1 human S782 3180399 ySLLrGGsDDsskDP PARP_reg X X +PRKACA PKACA P17612 human PIK3R1 5295 P27986 PIK3R1 human S83 471075 yIGRKKIsPPtPKPR X +PRKACA PKACA P17612 human CYP3A4 1576 P08684 CYP3A4 human S134 17547617 kRLRsLLsPtFTsGK p450 X +PRKACA PKACA P17612 human HNF4 alpha 25735 P22449 Hnf4a rat S142 458368 DRISTRRssYEDSSL X +PRKACA PKACA P17612 human TNNI3 29248 P23693 Tnni3 rat S24 448424 APVRRRssANYRAYA Troponin-I_N X 4004 +PRKACA PKACA P17612 human DAP3 7818 P51398 DAP3 human S185 2226206 FDQPLEAstWLkNFk DAP3 X +PRKACA PKACA P17612 human RFC1 89809 D3ZFT1 Rfc1 rat S361 3136107 GSPTKREsVsPEDSE X X +PRKACA PKACA P17612 human STAR 20845 P51557 Star mouse S194 450442 RCTKRRGsTCVLAGM START X +PRKACA PKACA P17612 human MORC2 22880 Q9Y6X9 MORC2 human T582 30982293 LEALQkTtPIRSQAD X +PRKACA PKACA P17612 human KCNJ13 3769 O60928 KCNJ13 human S287 6039503 EICQRRTsYLPSEIM IRK_C X +PRKACA PKACA P17612 human Titin 22138 A2ASS6 Ttn mouse T4046 2523800 QELLSKEtLFPSMPE X +PRKACA PKACA P17612 human CFTR 1080 P13569 CFTR human S795 449982 TAsTRKVsLAPQANL CFTR_R X X +PRKACA PKACA P17612 human GABRB1 14400 P50571 Gabrb1 mouse S409 451812 IQyRKPLssREGFGR Neur_chan_memb X +PRKACA PKACA P17612 human PREX1 57580 Q8TCU6 PREX1 human S436 2526571 KDRRRKLstVPKCFL DEP X X +PRKACA PKACA P17612 human ADRB1 153 P08588 ADRB1 human S312 469625 RAGKRRPsRLVALRE 7tm_1 X +PRKACA PKACA P17612 human RASGRP2 361714 P0C643 Rasgrp2 rat S586 10993875 PRPGRRSsRPPEIRE X +PRKACA PKACA P17612 human CTNNB1 1499 P35222 CTNNB1 human S552 472273 QDtQRRtsMGGtQQQ X 9566; 5651 +PRKACA PKACA P17612 human Oct4 5460 Q01860 POU5F1 human S289 22830418 RQKGKRsssDyAQRE X +PRKACA PKACA P17612 human CDKN2D 1032 P55273 CDKN2D human T141 25256101 RRDARGLtPLELALQ Ank_2 X +PRKACA PKACA P17612 human HIF1A 3091 Q16665 HIF1A human S761 56589708 RVKGCKssEQNGMEQ X +PRKACA PKACA P17612 human HCN4 330953 O70507 Hcn4 mouse S14 8086705 SMRKRLYsLPQQVGA X +PRKACA PKACA P17612 human AID 11628 Q9WVE0 Aicda mouse S38 457604 YVVKRRDsATsCSLD APOBEC2 X +PRKACA PKACA P17612 human RAP1B 327708 P61223 RAP1B cow S180 22689703 GKARKKssCQLL___ X +PRKACA PKACA P17612 human MYBPC3 17868 O70468 Mybpc3 mouse S307 2846505 RDsFRRDskLEAPAE X +PRKACA PKACA P17612 human STMN1 16765 P54227 Stmn1 mouse S16 448554 KELEKRAsGQAFELI Stathmin X 3353 +PRKACA PKACA P17612 human CASP9 842 P55211 CASP9 human S183 448528 GLRTRTGsNIDCEkL Peptidase_C14 X X +PRKACA PKACA P17612 human CUTL1 1523 P39880 CUX1 human S1237 456479 tEysQGAsPQPQHQL X +PRKACA PKACA P17612 human K8 25626 Q10758 Krt8 rat S37 456882 GARIsSSsFsRVGss Keratin_2_head X +PRKACA PKACA P17612 human CTNNB1 1499 P35222 CTNNB1 human T41 447583 GIHsGATtTAPsLsG X 9561; 9565; 4270; 13537; 41334; 60180 +PRKACA PKACA P17612 human MYBPC3 17868 O70468 Mybpc3 mouse S589 1877150002 PDNRIKVsHIGRVHK I-set X +PRKACA PKACA P17612 human FCER1G 2207 P30273 FCER1G human S69 13310016 DGVytGLstRNQEty ITAM X +PRKACA PKACA P17612 human PHF2 5253 O75151 PHF2 human S954 20936501 QKSKKKKsAKRKLTP X X +PRKACA PKACA P17612 human CREM iso2 12916 P27699-2 Crem mouse S84 448412 EILSRRPsYRKILNE pKID X +PRKACA PKACA P17612 human CFTR 1080 P13569 CFTR human S700 449978 FGEKRkNsILNPINs CFTR_R X X +PRKACA PKACA P17612 human SHIP 16331 Q9ES52 Inpp5d mouse T964 4778428 GRGEGPPtPPsQPPL X +PRKACA PKACA P17612 human TRIP10 9322 Q15642 TRIP10 human T225 1868832804 DMDERRAtRLGAGYG X X +PRKACA PKACA P17612 human PKACA 282322 P00517 PRKACA cow S15 9768112 KKGsEQEsVKEFLAK X +PRKACA PKACA P17612 human CACNA1D 29716 P27732 Cacna1d rat S1816 6062701 AAHGKRPsIGDLEHV CAC1F_C X X +PRKACA PKACA P17612 human HDAC4 9759 P56524 HDAC4 human S584 41452201 EPGQRQPsEQELLFR X X +PRKACA PKACA P17612 human AA-NAT 443531 Q29495 AANAT sheep T31 452141 PGRQRRHtLPANEFR X +PRKACA PKACA P17612 human NOLC1 64896 P41777 Nolc1 rat S627 455685 KKGEKRAssPFRRVR X +PRKACA PKACA P17612 human CAMKK1 60341 P97756 Camkk1 rat T108 452083 PRAWRRPtIESHHVA X +PRKACA PKACA P17612 human K8 25626 Q10758 Krt8 rat S34 3179200 sGPGARIsSSsFsRV Keratin_2_head X +PRKACA PKACA P17612 human ICLN 403971 P35521 CLNS1A dog S45 456841 YIAESRLsWLDGSGL Voldacs X +PRKACA PKACA P17612 human hnRNP D0 3184 Q14103 HNRNPD human S87 449337 sNssPRHsEAAtAQr X +PRKACA PKACA P17612 human RGS10 iso1 6001 O43665-1 RGS10 human S168 455907 QTAAkRAsRIyNT__ X X +PRKACA PKACA P17612 human ARPP-19 60336 Q712U5 Arpp19 rat S104 477874 DLPQRKPsLVASkLA Endosulfine X +PRKACA PKACA P17612 human ROMK 24521 P35560 Kcnj1 rat S313 2461200 ATCQVRTsYVPEEVL IRK_C X +PRKACA PKACA P17612 human IP3R1 16438 P11881 Itpr1 mouse S1755 450682 RPSGRREsLtsFGNG X X 3760; 8548 +PRKACA PKACA P17612 human Desmoplakin 1832 P15924 DSP human S2849 451165 RsGsRRGsFDAtGNs X +PRKACA PKACA P17612 human FOXO1A 56458 Q9R1E0 Foxo1 mouse S273 1253812002 RAAKKkAsLQSGQEG X +PRKACA PKACA P17612 human CACNA1D 29716 P27732 Cacna1d rat S52 6062710 ssKQtVLsWQAAIDA X +PRKACA PKACA P17612 human desmin 1674 P17661 DES human S12 449612 ysSSQRVssYRRtFG Filament_head X +PRKACA PKACA P17612 human GMF-beta 2764 P60983 GMFB human T27 451486 KFRFRKEtNNAAIIM Cofilin_ADF X +PRKACA PKACA P17612 human MBP 618684 P02687 MBP cow S7 451831 _AAQKRPsQRsKYLA X +PRKACA PKACA P17612 human ATR 545 Q13535 ATR human S435 477846 sPKRRRLsssLNPsk X X +PRKACA PKACA P17612 human NLRP3 216799 Q8R4B8 Nlrp3 mouse S291 57761902 CKILRKPsRILFLMD NACHT X +PRKACA PKACA P17612 human CDK9 1025 P50750 CDK9 human S347 3681502 APPRRkGsQItQQst X +PRKACA PKACA P17612 human SUN2 25777 Q9UH99 SUN2 human S12 448844 SQRLtRysQGDDDGs X +PRKACA PKACA P17612 human PKACA 282322 P00517 PRKACA cow S339 449886 EEEEIRVsINEKCGK X +PRKACA PKACA P17612 human TAGLN2 8407 P37802 TAGLN2 human S163 468770 kENPRNFsDNQLQEG X +PRKACA PKACA P17612 human HSP90A 3320 P07900 HSP90AA1 human T90 476047 NkQDRtLtIVDtGIG HATPase_c X X +PRKACA PKACA P17612 human AMPKB1 5564 Q9Y478 PRKAB1 human S24 448111 HKtPRRDssGGtKDG X +PRKACA PKACA P17612 human CYP2E1 1571 P05181 CYP2E1 human S145 23940000 MGKQGNEsRIQREAH p450 X +PRKACA PKACA P17612 human PPP2R5D 5528 Q14738 PPP2R5D human S60 457388 PsSNKRPsNstPPPt X +PRKACA PKACA P17612 human QIK 23235 Q9H0K1 SIK2 human S358 487501 DGRQRRPstIAEQTV X +PRKACA PKACA P17612 human NPM1 18148 Q61937 Npm1 mouse S125 459897 AVEEDAEsEDEDEED X +PRKACA PKACA P17612 human SYNE1 64009 Q6ZWR6 Syne1 mouse S732 4694833 TEAHRKLsEPLEVSF X +PRKACA PKACA P17612 human TGM2 7052 P21980 TGM2 human S215 467222 GRDCsRRssPVyVGR X +PRKACA PKACA P17612 human GJA1 24392 P08050 Gja1 rat S373 459209 RAssRAssRPRPDDL X X +PRKACA PKACA P17612 human GFAT2 14584 Q9Z2Z9 Gfpt2 mouse S202 451674 AVATRRGsPLLIGVR GATase_6 X +PRKACA PKACA P17612 human NDUFS4 4724 O43181 NDUFS4 human S173 2103602 WNkRTRVsTK_____ X +PRKACA PKACA P17612 human Tau iso2 4137 P10636-2 MAPT human S156 447929 GSRSRTPsLPTPPTR X 77348 +PRKACA PKACA P17612 human KCNN2 3781 Q9H2S1 KCNN2 human S568 460689 SsRRRrsssTAPPtS X X +PRKACA PKACA P17612 human RASD2 23551 Q96D21 RASD2 human S239 8097548 SPFARRPsVNSDLKY X X +PRKACA PKACA P17612 human STMN2 84510 P21818 Stmn2 rat S50 455606 KQINKRAsGQAFELI Stathmin X +PRKACA PKACA P17612 human smMLCK 4638 Q15746 MYLK human S1773 455821 GLsGRKsstGsPtsP X +PRKACA PKACA P17612 human Src 6714 P12931 SRC human Y419 448234 RLIEDNEytARQGAk PK_Tyr_Ser-Thr X 2101; 6943; 59548; 70926; 78740; 94361; 17320 +PRKACA PKACA P17612 human H2B 615043 P62808 H2BC19 cow S36 449903 RKRsRKEsYSVYVYK Histone X +PRKACA PKACA P17612 human BAD 12015 Q61337 Bad mouse S136 447862 PFRGRsRsAPPNLWA Bcl-2_BAD X 9295; 5286; 4366 +PRKACA PKACA P17612 human SPTBN1 6711 Q01082 SPTBN1 human T2159 471399 NGAtEQRtssKEssP X +PRKACA PKACA P17612 human STXBP5 81022 Q9WU70 Stxbp5 rat S724 459032 GSSSPHNsDDEQKVN X +PRKACA PKACA P17612 human SOX9 20682 Q04887 Sox9 mouse S211 450957 FKALQADsPHSSSGM X +PRKACA PKACA P17612 human NFAT2 4772 O95644 NFATC1 human S294 448863 PHGsPRVsVTDDSWL X X +PRKACA PKACA P17612 human ABCC9 20928 P70170 Abcc9 mouse S1465 483975 RAFVRKSsILIMDEA ABC_tran X +PRKACA PKACA P17612 human ARHGEF6 9459 Q15052 ARHGEF6 human S684 456737 GSSTRkDsIPQVLLP X +PRKACA PKACA P17612 human CYP3A4 1576 P08684 CYP3A4 human S259 22553301 SVKRMKEsRLEDtQK p450 X +PRKACA PKACA P17612 human AMPKA1 105787 Q5EG47 Prkaa1 mouse S508 4274314 RsCQRSDsDAEAQGK X +PRKACA PKACA P17612 human NFkB-p105 18033 P25799 Nfkb1 mouse S335 449967 FVQLRRKsDLETSEP RHD_dimer X +PRKACA PKACA P17612 human Plectin-1 5339 Q15149 PLEC human S4642 3196844 RAGsRrGsFDAtGsG X X +PRKACA PKACA P17612 human Snail1 6615 O95863 SNAI1 human S11 11493500 SFLVRKPsDPNRKPN X +PRKACA PKACA P17612 human PLCB3 5331 Q01970 PLCB3 human S1105 448448 LDRKRHNsIsEAKMR PLC-beta_C X X 2484 +PRKACA PKACA P17612 human AQP5 362 P55064 AQP5 human S156 1233703 STDSRRTsPVGSPAL MIP X +PRKACA PKACA P17612 human eNOS 24600 Q62600 Nos3 rat S614 448656 SYKIRFNsVSCSDPL Flavodoxin_1 X +PRKACA PKACA P17612 human Titin 7273 Q8WZ42 TTN human S4010 27842904 VRIEEGKsLRFPLAL X +PRKACA PKACA P17612 human CACNA1C 100101555 P15381 CACB rabbit S1627 10349704 KKIWKRTsMKLLDQV Ca_chan_IQ X +PRKACA PKACA P17612 human NACA iso2 17938 Q60817 Naca mouse S99 31834914 TRVTIRKsKNILFVI NAC X X +PRKACA PKACA P17612 human HIF1A 3091 Q16665 HIF1A human S760 56589710 KRVKGCKssEQNGME X +PRKACA PKACA P17612 human SHIP 16331 Q9ES52 Inpp5d mouse S977 15621806 PLsPKKFsSSTANRG X +PRKACA PKACA P17612 human PPP1R1C 151242 Q8WVI7 PPP1R1C human T34 2807902 QIRKRRPtPASLVIL DARPP-32 X +PRKACA PKACA P17612 human HDAC5 10014 Q9UQL6 HDAC5 human S279 4788487 KVAERRssPLLRRKD X X +PRKACA PKACA P17612 human DARPP-32 360616 Q6J4I0 Ppp1r1b rat T34 448047 MIRRRRPtPALLFRV DARPP-32 X 12438 +PRKACA PKACA P17612 human GJA8 395846 P36381 GJA8 chicken S387 9824608 VRSLSRLsKASSRAR X +PRKACA PKACA P17612 human CACNA1D 29716 P27732 Cacna1d rat S2165 6062705 NGDMGPIsHRQDYEL CAC1F_C X +PRKACA PKACA P17612 human SFRS2 6427 Q01130 SRSF2 human S128 29431802 sPRRRRRsRsRSRSR X X +PRKACA PKACA P17612 human DDC 1644 P20711 DDC human S193 1883995300 YSSDQAHsSVERAGL X +PRKACA PKACA P17612 human GSK3A 50686 P18265 Gsk3a rat S21 448584 SGRARtssFAEPGGG X X 9337; 9316; 9331; 9327; 8452; 8566 +PRKACA PKACA P17612 human SHIP 16331 Q9ES52 Inpp5d mouse S1114 15621808 SQGKPKAsASSQAPV X +PRKACA PKACA P17612 human STAR 6770 P49675 STAR human S57 450440 NQVRRRssLLGsRLE X +PRKACA PKACA P17612 human TGM2 7052 P21980 TGM2 human S216 467223 RDCsRRssPVyVGRV X +PRKACA PKACA P17612 human PDZK1 65144 Q9JJ40 Pdzk1 rat S509 456807 PARDRTLsAAsHsss X X +PRKACA PKACA P17612 human PPP1R1A P01099 PPP1R1A rabbit S67 447758 LKPSLAMsPRQRKKM DARPP-32 X +PRKACA PKACA P17612 human SREBP-1 iso3 6720 P36956-3 SREBF1 human S314 458357 IEKRYRSsINDKIIE HLH X X +PRKACA PKACA P17612 human AQP5 11830 Q9WTY4 Aqp5 mouse T259 460666 HREERKKtIELTAH_ X +PRKACA PKACA P17612 human SLK 9748 Q9H2G2 SLK human S189 468769 RtIQRRDsFIGtPyW Pkinase X +PRKACA PKACA P17612 human CAMKK1 60341 P97756 Camkk1 rat S458 486077 KSMLRKRsFGNPFEP X +PRKACA PKACA P17612 human K8 25626 Q10758 Krt8 rat S51 13201907 ssssFRGsLGGFGGA Keratin_2_head X +PRKACA PKACA P17612 human RASSF1 iso2 11186 Q9NS23-2 RASSF1 human S203 484000 TsVRRRtsFYLPKDA RA X +PRKACA PKACA P17612 human GFAT iso2 2673 Q06210-2 GFPT1 human S235 1232948 TGkDKkGsCNLsRVD X +PRKACA PKACA P17612 human rabphilin 3A 171039 P47709 Rph3a rat S274 455801 QGLRRANsVQASRPA X +PRKACA PKACA P17612 human p47phox 653361 P14598 NCF1 human S359 451729 EERQtQRsKPQPAVP p47_phox_C X +PRKACA PKACA P17612 human GLI3 2737 P10071 GLI3 human S877 15501382 CFssRRssEASQAEG X X +PRKACA PKACA P17612 human VASP 7408 P50552 VASP human S157 448379 EHIERRVsNAGGPPA X X 3111; 84519 +PRKACA PKACA P17612 human ER-alpha 2099 P03372 ESR1 human S305 448805 IkRSkkNsLALSLtA X X +PRKACA PKACA P17612 human SHIP 16331 Q9ES52 Inpp5d mouse S246 4778386 RLFDQQLsPGLRPRP X +PRKACA PKACA P17612 human SIK 59329 Q9R1U5 Sik1 rat S577 465992 FQEGRRAsDTSLTQG X +PRKACA PKACA P17612 human PARP1 142 P09874 PARP1 human S785 21440500 LrGGsDDsskDPIDV PARP_reg X X +PRKACA PKACA P17612 human ANPA 4881 P16066 NPR1 human S529 447512 RHLRSAGsRLtLsGR X +PRKACA PKACA P17612 human ACADVL 37 P49748 ACADVL human S586 22680600 VVVLSRAsRSLSEGH X X +PRKACA PKACA P17612 human MYBPC3 17868 O70468 Mybpc3 mouse S273 471079 RsAFRRtsLAGAGRR X +PRKACA PKACA P17612 human AQP2 25386 P34080 Aqp2 rat S256 449854 REVRRRQsVELHsPQ X +PRKACA PKACA P17612 human NKD2 85409 Q969F2 NKD2 human S223 3949685 sAHVRRPstDPQPCs X +PRKACA PKACA P17612 human CAD 790 P27708 CAD human H1856 27989100 FHLPPRIhRAsDPGL X +PRKACA PKACA P17612 human Huntingtin 3064 P42858 HTT human S2548 40422837 TRFGRKLsIIRGIVE X X +PRKACA PKACA P17612 human HSP20 126393 O14558 HSPB6 human S16 450706 PSWLRRAsAPLPGLS Crystallin X X 36519 +PRKACA PKACA P17612 human SLC14A2 54302 Q62668 Slc14a2 rat S499 2813500 WSsIRRRsKVFGKSE X +PRKACA PKACA P17612 human CREB 12912 Q01147 Creb1 mouse S119 448228 EILsRRPsyRkILND pKID X 9187; 9196; 9198; 4095; 14228; 14001; 39561; 80120; 44864; 54960; 95995 +PRKACA PKACA P17612 human NETO2 307757 C6K2K4 Neto2 rat S409 4752528 SLREKEIsADLADLS X +PRKACA PKACA P17612 human NDUFS4 Q02375 NDUFS4 cow S173 2103602 WNKRTRVsTK_____ X +PRKACA PKACA P17612 human PAK6 56924 Q9NQU5 PAK6 human S113 5208141 TSRRRAQsLGLLGDE X +PRKACA PKACA P17612 human RXRA 6256 P19793 RXRA human S27 3188103 tsPTGRGsMAAPsLH Nuc_recep-AF1 X X +PRKACA PKACA P17612 human TH iso3 7054 P07101-3 TH human S40 448545 RFIGRRQsLIEDARK TOH_N X X 2791 +PRKACA PKACA P17612 human SLC26A4 5172 O43511 SLC26A4 human T717 22561300 DDNIRKDtFFLTVHD STAS X +PRKACA PKACA P17612 human SHIP 16331 Q9ES52 Inpp5d mouse S935 4778416 LHGKsTLsPDQQLtA X +PRKACA PKACA P17612 human PKD2L1 9033 Q9P0L9 PKD2L1 human S686 394791407 LGRsIVssPQGKSGP X +PRKACA PKACA P17612 human GJD2 14617 O54851 Gjd2 mouse S110 471386 KQRERRYsTVFLALD Connexin X +PRKACA PKACA P17612 human ROMK 24521 P35560 Kcnj1 rat S44 449605 RQRARLVsKEGRCNI IRK X +PRKACA PKACA P17612 human CFTR 1080 P13569 CFTR human S813 449983 DIYsRRLsQEtGLEI CFTR_R X X +PRKACA PKACA P17612 human nAChRA4 25590 P09483 Chrna4 rat S365 467262 LLFMKRPsVVKDNCR Neur_chan_memb X +PRKACA PKACA P17612 human GATA3 2625 P23771 GATA3 human S308 456464 IKPkRRLsAARRAGT X +PRKACA PKACA P17612 human TPPP 11076 O94811 TPPP human S32 456613 DRAAKRLsLEsEGAG X +PRKACA PKACA P17612 human AKAP13 11214 Q12802 AKAP13 human S2733 455336 sVsPKRNsISRTHKD X X +PRKACA PKACA P17612 human SUN2 25777 Q9UH99 SUN2 human S116 448846 GsEssRAsGLVGRKA X +PRKACA PKACA P17612 human CDK16 5127 Q00536 CDK16 human S12 453448 KKIKRQLsMtLRGGr X +PRKACA PKACA P17612 human KCNJ2 3759 P63252 KCNJ2 human S425 10892807 PRPLRREsEI_____ X +PRKACA PKACA P17612 human KCNN4 65206 Q9QYW1 Kcnn4 rat S332 452145 KHtRRKDsRAARRHQ CaMBD X +PRKACA PKACA P17612 human HCN4 330953 O70507 Hcn4 mouse S117 15103408 sGGAGGGsSLGHLHD X +PRKACA PKACA P17612 human ARHGEF7 114559 O55043 Arhgef7 rat T526 455216 EFAVRKStAALEEDA RhoGEF67_u2 X X +PRKACA PKACA P17612 human 5-LO 240 P09917 ALOX5 human S448 33670304 MKDLtyAsLCFPEAI Lipoxygenase X +PRKACA PKACA P17612 human TNNI3 7137 P19429 TNNI3 human S24 448424 APIRRRssNyRAyAt Troponin-I_N X X 4004 +PRKACA PKACA P17612 human GABBR2 83633 O88871 Gabbr2 rat S892 450809 EHIQRRLsLQLPILH X +PRKACA PKACA P17612 human SUFU 51684 Q9UMX1 SUFU human S346 4786848 RAPsRkDsLEsDSst SUFU_C X +PRKACA PKACA P17612 human IMMT 10989 Q16891 IMMT human S528 55571502 ELQFRRLsQEQVDNF Mitofilin X X +PRKACA PKACA P17612 human AQP4 361 P55087 AQP4 human S276 465556 AAQQTKGsyMEVEDN X +PRKACA PKACA P17612 human ABCC8 Q09427 ABCC8 hamster S1447 22634903 LDPEKKCsDSTLWEA ABC_tran X X +PRKACA PKACA P17612 human TRPM8 79054 Q7Z2W7 TRPM8 human T17 12570902 MRNRRNDtLDSTRTL X +PRKACA PKACA P17612 human MBP 618684 P02687 MBP cow S114 451753 GLsLSRFsWGAEGQK Myelin_MBP X +PRKACA PKACA P17612 human SFRS2 6427 Q01130 SRSF2 human S130 29431800 RRRRRsRsRSRSRSR X X +PRKACA PKACA P17612 human RYR2 6262 Q92736 RYR2 human S2808 448848 YNRTRRIsQTSQVsV X +PRKACA PKACA P17612 human 5-LO 240 P09917 ALOX5 human S671 33670305 sPDRIPNsVAI____ X +PRKACA PKACA P17612 human Tau iso8 4137 P10636-8 MAPT human S416 454127 sNVsstGsIDMVDsP X 15013; 61160 +PRKACA PKACA P17612 human IGFBP1 3484 P08833 IGFBP1 human S194 451660 LAKAQETsGEEIsKF Thyroglobulin_1 X +PRKACA PKACA P17612 human MC4R 4160 P32245 MC4R human T312 449101 RSQELRKtFKEIICC X +PRKACA PKACA P17612 human KCNMA1 iso2 16531 Q08460-2 Kcnma1 mouse S899 469989 HGMLRQPsITTGVNI X +PRKACA PKACA P17612 human GPR15 2838 P49685 GPR15 human S357 125971702 FARRRKRsVsL____ X X +PRKACA PKACA P17612 human CEACAM1 634 P13688 CEACAM1 human S472 1875094100 DLTEHKPsVSNHTQD X +PRKACA PKACA P17612 human KCNK3 3777 O14649 KCNK3 human S393 2840504 GLMKRRssV______ X X +PRKACA PKACA P17612 human calpastatin 831 P20810 CAST human S133 7320476 DKKKEKKsLtPAVPV Calpain_inhib X +PRKACA PKACA P17612 human RFC1 89809 D3ZFT1 Rfc1 rat S245 468617 TKKARKDsEEGESFs X X +PRKACA PKACA P17612 human Kv7.1 3784 P51787 KCNQ1 human S27 2999203 LPGARRGsAGLAKKC X +PRKACA PKACA P17612 human E2F1 1869 Q01094 E2F1 human S235 1870773100 TTQLRLLsEDTDSQR E2F_CC-MB X +PRKACA PKACA P17612 human Tau iso8 4137 P10636-8 MAPT human S305 487457 kHVPGGGsVQIVykP Tubulin-binding X +PRKACA PKACA P17612 human TACC3 10460 Q9Y6A5 TACC3 human S558 474537 ESALRKQsLyLkFDP X 8842; 5645 +PRKACA PKACA P17612 human LXR-alpha 22259 Q9Z0Y9 Nr1h3 mouse T290 479433 DQIALLKtsAIEVML Hormone_recep X X +PRKACA PKACA P17612 human CPEB3 208922 Q7TN99 Cpeb3 mouse S291 25288000 PsPLNPIsPLKKPFs X +PRKACA PKACA P17612 human CASK 29647 Q62915 Cask rat T724 12568401 LPAFKRKtLVLLGAH Guanylate_kin X X +PRKACA PKACA P17612 human GYS1 100008660 P13834 GYS1 rabbit S8 449898 MPLSRTLsVSsLPGL X +PRKACA PKACA P17612 human CACNA1D 29716 P27732 Cacna1d rat S1703 6062702 PEIRRAIsCDLQDDE CAC1F_C X +PRKACA PKACA P17612 human CEACAM1 634 P13688 CEACAM1 human S512 29576348 QPTsAsPsLTATEII X +PRKACA PKACA P17612 human IRE1 78943 Q9EQY0 Ern1 mouse S724 7161100 KLAVGRHsFSRRsGV Pkinase X +PRKACA PKACA P17612 human ROMK iso2 P35560-2 Kcnj1 rat S25 449605 RQRARLVsKEGRCNI IRK X X +Grk3 GRK3 Q3UYH7 mouse SMO 319757 P56726 Smo mouse T597 1872776116 ELSFsMHtVsHDGPV X +Grk3 GRK3 Q3UYH7 mouse SMO 319757 P56726 Smo mouse S642 1872776120 AILPQDVsVtPVAtP X +Grk3 GRK3 Q3UYH7 mouse KOR-1 18387 P33534 Oprk1 mouse T357 52467201 MRMERQstNRVRNtV X +Grk3 GRK3 Q3UYH7 mouse SMO 319757 P56726 Smo mouse S599 1872776118 SFsMHtVsHDGPVAG X +Grk3 GRK3 Q3UYH7 mouse MOR-1 18390 P42866 Oprm1 mouse T376 20727901 NtREHPstANtVDRT X +Grk3 GRK3 Q3UYH7 mouse KOR-1 18387 P33534 Oprk1 mouse S356 52467200 KMRMERQstNRVRNt X +Grk3 GRK3 Q3UYH7 mouse SMO 319757 P56726 Smo mouse S560 1872776110 WCRLTGHsDDEPKRI X +Grk3 GRK3 Q3UYH7 mouse SMO 319757 P56726 Smo mouse S594 1872776114 PGQELSFsMHtVsHD X +Grk3 GRK3 Q3UYH7 mouse SMO 319757 P56726 Smo mouse T644 1872776122 LPQDVsVtPVAtPVP X +Grk3 GRK3 Q3UYH7 mouse MOR-1 18390 P42866 Oprm1 mouse T370 447785 sARIRQNtREHPstA X +Grk3 GRK3 Q3UYH7 mouse MOR-1 18390 P42866 Oprm1 mouse S375 447784 QNtREHPstANtVDR X 3451 +Grk3 GRK3 Q3UYH7 mouse SMO 319757 P56726 Smo mouse T648 1872776124 VsVtPVAtPVPPEEQ X +Grk3 GRK3 Q3UYH7 mouse MOR-1 18390 P42866 Oprm1 mouse T379 20727900 EHPstANtVDRTNHQ X +Mapk7 ERK5 Q9WVS8 mouse ERK5 23939 Q9WVS8 Mapk7 mouse S760 14561007 PQDGQADsASLsAsL X X +Mapk7 ERK5 Q9WVS8 mouse ERK5 23939 Q9WVS8 Mapk7 mouse T723 455520 LPPVFsGtPKGSGAG X X +Mapk7 ERK5 Q9WVS8 mouse ERK5 23939 Q9WVS8 Mapk7 mouse S764 14561006 QADsASLsAsLLADW X X +Mapk7 ERK5 Q9WVS8 mouse NFAT3 73181 Q8K120 Nfatc4 mouse S170 448860 GGAFFsPsPGSSSLS X +Mapk7 ERK5 Q9WVS8 mouse ERK5 23939 Q9WVS8 Mapk7 mouse S766 14561005 DsASLsAsLLADWLE X X +Mapk7 ERK5 Q9WVS8 mouse NFAT3 73181 Q8K120 Nfatc4 mouse S168 448859 QGGGAFFsPsPGSSS X +Mark1 MARK1 O08678 rat Tau iso8 4137 P10636-8 MAPT human S262 447930 NVKskIGstENLkHQ Tubulin-binding X +Mark1 MARK1 O08678 rat Tau iso8 4137 P10636-8 MAPT human S324 449328 kVtskCGsLGNIHHk Tubulin-binding X +Mark1 MARK1 O08678 rat Tau iso8 4137 P10636-8 MAPT human S293 449327 NVQskCGsKDNIkHV Tubulin-binding X +Mark1 MARK1 O08678 rat Tau iso8 4137 P10636-8 MAPT human S356 449104 rVQskIGsLDNItHV Tubulin-binding X +Mark1 MARK1 O08678 rat Tau 29477 P19332 Mapt rat S573 447930 NVRSKIGsTENLKHQ Tubulin-binding X +ALDOB ALDOB P79226 rabbit ALDOB 100328925 P79226 ALDOB rabbit Y362 451309 QSLFTASyTY_____ Glycolytic X +MAPK3 ERK1 P27361 human BRAF 673 P15056 BRAF human T401 452246 sTtGLsAtPPAsLPG X X +MAPK3 ERK1 P27361 human Tau iso8 4137 P10636-8 MAPT human T231 449079 KKVAVVRtPPKsPss X 20473; 71429 +MAPK3 ERK1 P27361 human WTAP 9589 Q15007 WTAP human S341 3196721 AGYESVDsPtGsENs X +MAPK3 ERK1 P27361 human CRYAB 25420 P23928 Cryab rat S45 448748 FSTATSLsPFYLRPP Crystallin X +MAPK3 ERK1 P27361 human DUSP6 1848 Q16828 DUSP6 human S174 5938001 LGGLRISsDSSsDIE X +MAPK3 ERK1 P27361 human HNF4 alpha 3172 P41235 HNF4A human S148 26419226 RssyEDssLPsINAL X +MAPK3 ERK1 P27361 human TIF1A 54700 Q9NYV6 RRN3 human S633 448838 SFDTHFRsPssSVGs X +MAPK3 ERK1 P27361 human TH iso4 7054 P07101-4 TH human S35 448544 AIMVRGQsPRFIGRR TOH_N X +MAPK3 ERK1 P27361 human GATA1 14460 P17679 Gata1 mouse S26 451232 VDSALVSsPSDSTGF X +MAPK3 ERK1 P27361 human NUP153 9972 P49790 NUP153 human T388 3191107 VyFkPsLtPsGEFRK Nup153 X X +MAPK3 ERK1 P27361 human RAF1 5894 P04049 RAF1 human S301 455219 sssPNNLsPtGWsQP X X 9431 +MAPK3 ERK1 P27361 human ATF-2 1386 P15336 ATF2 human T69 448224 sVIVADQtPtPtRFL X 9225; 94125; 40749; 61584; 44167 +MAPK3 ERK1 P27361 human PXN iso2 5829 P49023-2 PXN human S83 451113 FIHQQPQsssPVyGs Paxillin X +MAPK3 ERK1 P27361 human p90RSK 81771 Q63531 Rps6ka1 rat T359 447992 DTEFTSRtPRDsPGI Pkinase_C X 9344 +MAPK3 ERK1 P27361 human STAT1 6772 P42224 STAT1 human S727 447753 TDNLLPMsPEEFDEV STAT1_TAZ2bind X 9177; 8826; 62390 +MAPK3 ERK1 P27361 human KLC1 171041 P37285 Klc1 rat S460 477826 YKACKVDsPTVTTTL X +MAPK3 ERK1 P27361 human Mnk1 8569 Q9BUB5 MKNK1 human T385 447623 APEKGLPtPQVLQRN X +MAPK3 ERK1 P27361 human Tau iso8 4137 P10636-8 MAPT human S199 447927 GDRsGyssPGsPGtP X X 29957 +MAPK3 ERK1 P27361 human FGFR2 2263 P21802 FGFR2 human S780 34500854 SQPLEQYsPsYPDTR X X +MAPK3 ERK1 P27361 human SHARPIN 81858 Q9H0F6 SHARPIN human S146 31883820 ACPVsLPsPPEAStL X X +MAPK3 ERK1 P27361 human HSPB8 26353 Q9UJY1 HSPB8 human S24 2201402 RRDPFRDsPLsSRLL X +MAPK3 ERK1 P27361 human TMEM55B 219024 Q3TWL2 Pip4p1 mouse S169 3204510 PVHPGPLsPEPQPMG Tmemb_55A X +MAPK3 ERK1 P27361 human p47phox 653361 P14598 NCF1 human S348 451728 PGPQsPGsPLEEERQ X +MAPK3 ERK1 P27361 human BVR 644 P53004 BLVRA human S230 478716 LKRNRyLsFHFksGs Biliv-reduc_cat X +MAPK3 ERK1 P27361 human NPAS4 225872 Q8BGD7 Npas4 mouse S580 1871095702 KLPPsPSsPGNGDCT X +MAPK3 ERK1 P27361 human TH iso2 7054 P07101-2 TH human S58 448544 SYTPTPRsPRFIGRR TOH_N X +MAPK3 ERK1 P27361 human SPHK1 8877 Q9NYA1 SPHK1 human S225 460682 VGSKTPAsPVVVQQG X +MAPK3 ERK1 P27361 human ATF-2 1386 P15336 ATF2 human T71 448225 IVADQtPtPtRFLkN X X 9225; 9221; 5112; 94125; 13850; 40749; 15411; 24329; 61584; 27934; 92109; 20534; 35858 +MAPK3 ERK1 P27361 human GRASP55 26003 Q9H8Y8 GORASP2 human T222 470124 LPGQMAGtPItPLKD X +MAPK3 ERK1 P27361 human TACE 6868 P78536 ADAM17 human T735 449804 kPFPAPQtPGRLQPA X X +MAPK3 ERK1 P27361 human NSMF 117536 Q9EPI6 Nsmf rat S180 27713502 AKLVPGPsPRAFGLE X +MAPK3 ERK1 P27361 human REST 5978 Q13127 REST human S861 36320700 sVsTEDLsPPsPPLP X +MAPK3 ERK1 P27361 human TOB1 10140 P50616 TOB1 human S154 455536 SSVSSsPsPPFGHSA X X +MAPK3 ERK1 P27361 human TSC2 7249 P49815 TSC2 human S664 455575 KkTSGPLsPPTGPPG Tuberin X 40729 +MAPK3 ERK1 P27361 human Bcl-2 596 P10415 BCL2 human T74 448632 ARtsPLQtPAAPGAA X +MAPK3 ERK1 P27361 human PPAR-gamma 19016 P37238 Pparg mouse S133 38507801 PHEEPSNsLMAIECR X +MAPK3 ERK1 P27361 human NPAS4 225872 Q8BGD7 Npas4 mouse T427 1869686800 LVCTPPYtPHQPGGC X +MAPK3 ERK1 P27361 human ASL 435 P04424 ASL human S417 1880040200 LQELQTIsPLFSGDV X +MAPK3 ERK1 P27361 human AML3 860 Q13950 RUNX2 human S312 10892802 SYLSQMTsPsIHSTT X X +MAPK3 ERK1 P27361 human WAVE2 10163 Q9Y6W5 WASF2 human S343 18715501 PPPVGFGsPGtPPPP X +MAPK3 ERK1 P27361 human PDE6G 281977 P04972 PDE6G cow T22 449334 RVMGGPVtPRKGPPK PDE6_gamma X +MAPK3 ERK1 P27361 human PXN iso2 5829 P49023-2 PXN human S126 450227 sFPNKQKsAEPsPtV Paxillin X +MAPK3 ERK1 P27361 human ELK4 2005 P28324 ELK4 human S387 4317601 LsPVAPLsPARLQGA X X +MAPK3 ERK1 P27361 human MITF iso9 4286 O75030-9 MITF human S73 450264 PGSSAPNsPMAMLTL MITF_TFEB_C_3_N X +MAPK3 ERK1 P27361 human SMAD2 Q1W668 SMAD2 cow S245 448794 NQSMDTGsPAELsPT X +MAPK3 ERK1 P27361 human MTMR2 8898 Q13614 MTMR2 human S58 3195800 StSADNFsPDLRVLR X X +MAPK3 ERK1 P27361 human GAB2 14389 Q9Z1S8 Gab2 mouse S612 454021 ALDFQPGsPsPHRKP X X +MAPK3 ERK1 P27361 human TORC3 64784 Q6UUV7 CRTC3 human S391 3203130 RRRQPPVsPLtLsPG X +MAPK3 ERK1 P27361 human DRP1 74006 Q8K1M6 Dnm1l mouse S622 454690 PIPIMPAsPQKGHAV X 3455; 4494; 63940 +MAPK3 ERK1 P27361 human WTAP 9589 Q15007 WTAP human S306 453808 tEDDFPssPGNGNKs X +MAPK3 ERK1 P27361 human Tel 2120 P41212 ETV6 human S257 451378 ESHPKPSsPRQESTR X X +MAPK3 ERK1 P27361 human ELK1 2002 P19419 ELK1 human S389 449757 LsPIAPRsPAKLSFQ X X +MAPK3 ERK1 P27361 human LYL1 4066 P12980 LYL1 human S36 15624701 APPPKPAsPGPPQVE X +MAPK3 ERK1 P27361 human ISX 91464 Q2M1V0 ISX human S183 1874101900 RRLAPPTsCCPSAQD X X +MAPK3 ERK1 P27361 human NIPA 232679 Q80YV2 Zc3hc1 mouse S353 449745 PIVsRtRsWEsssPV X +MAPK3 ERK1 P27361 human SP1 6667 P08047 SP1 human S59 452233 GGQEsQPsPLALLAA X X +MAPK3 ERK1 P27361 human RAGE 11596 Q62151 Ager mouse S376 4731271 EERKAPEsQEDEEER X +MAPK3 ERK1 P27361 human DUSP5 1847 Q16690 DUSP5 human S346 10206800 IGHLQTLsPDMQGAY X +MAPK3 ERK1 P27361 human CASP9 842 P55211 CASP9 human T125 449563 PEVLRPEtPRPVDIG X +MAPK3 ERK1 P27361 human DUSP6 1848 Q16828 DUSP6 human S159 455265 DGSCSSSsPPLPVLG X +MAPK3 ERK1 P27361 human LAT iso2 27040 O43561-2 LAT human T155 451994 PSAPALStPGIRDSA LAT X X +MAPK3 ERK1 P27361 human SRC-1 8648 Q15788 NCOA1 human T1179 449063 NYGTNPGtPPASTsP DUF1518 X +MAPK3 ERK1 P27361 human ER-alpha 2099 P03372 ESR1 human S104 448099 FPPLNsVsPsPLMLL Oest_recep X +MAPK3 ERK1 P27361 human AML3 860 Q13950 RUNX2 human S294 10892804 DPRQAQSsPPWSYDQ X X +MAPK3 ERK1 P27361 human PSD-93 64053 Q63622 Dlg2 rat S323 472024 KTSLPPIsPGRysPI PDZ_assoc X +MAPK3 ERK1 P27361 human RHOA 387 P61586 RHOA human S88 53332703 LMCFSIDsPDSLENI Ras X X +MAPK3 ERK1 P27361 human smMLCK 4638 Q15746 MYLK human T978 15423395 VPPPKPAtPDFRSVL X +MAPK3 ERK1 P27361 human CTNND1 1500 O60716 CTNND1 human T906 469141 sLDNNystPNERGDH X X +MAPK3 ERK1 P27361 human GATA1 14460 P17679 Gata1 mouse S178 451236 PFFSPTGsPLSSAAY X +MAPK3 ERK1 P27361 human CBP 1387 Q92793 CREBBP human S93 20615901 IGNVSASsPVQQGLG X +MAPK3 ERK1 P27361 human ARRB2 409 P32121 ARRB2 human S14 23083983 TRVFKKssPNCKLtV X +MAPK3 ERK1 P27361 human AML1 iso8 861 Q01196-8 RUNX1 human S276 454399 DTRQIQPsPPWSYDQ X +MAPK3 ERK1 P27361 human CACNB1 50688 P54283 Cacnb1 rat S348 459046 IVYIKITsPKVLQRL Guanylate_kin X +MAPK3 ERK1 P27361 human MFN1 192647 Q8R4Z9 Mfn1 rat T562 40416800 VPRSLAStPTAPSNP X X +MAPK3 ERK1 P27361 human SMURF1 57154 Q9HCE7 SMURF1 human T223 1877492900 DVRGSLQtPQNRPHG X X +MAPK3 ERK1 P27361 human NG2 81651 Q00657 Cspg4 rat T2314 483998 ELLQFCRtPNPALRN X +MAPK3 ERK1 P27361 human FRA2 14284 P47930 Fosl2 mouse T322 14573760 SDSLNsPtLLAL___ X +MAPK3 ERK1 P27361 human Fos 2353 P01100 FOS human S374 448482 PSSDSLSsPtLLAL_ X +MAPK3 ERK1 P27361 human JAK2 16452 Q62120 Jak2 mouse S523 465671 GISDVQIsPtLQRHN X +MAPK3 ERK1 P27361 human MCR 4306 P08235 NR3C2 human S196 25692901 EKSPSVCsPLNMTSS X X +MAPK3 ERK1 P27361 human Abi-1 10006 Q8IZP0 ABI1 human S410 12626407 DIPMFDDsPPPPPPP X +MAPK3 ERK1 P27361 human NUP214 8021 P35658 NUP214 human S1809 10296401 NAPAFGQsPGFGQGG X +MAPK3 ERK1 P27361 human MZF-1 109889 O70162 Mzf1 mouse S336 448731 EEVGGIFsPGFTLQM X +MAPK3 ERK1 P27361 human SMAD2 4087 Q15796 SMAD2 human S255 448796 ELsPTTLsPVNHsLD X X 3104 +MAPK3 ERK1 P27361 human DLC1 50768 Q9R0Z9 Dlc1 mouse S129 20651248 KQDPIPGsPDNSRLQ X X +MAPK3 ERK1 P27361 human TOP2A 7153 P11388 TOP2A human S1247 452238 kNENtEGsPQEDGVE X +MAPK3 ERK1 P27361 human Fos 2353 P01100 FOS human T232 448491 GGLPEVAtPESEEAF X +MAPK3 ERK1 P27361 human ITGB4 3691 P16144 ITGB4 human S1356 451653 ysDDVLRsPSGsQRP X +MAPK3 ERK1 P27361 human DAT 24898 P23977 Slc6a3 rat T53 6843600 TLINPPQtPVEAQER X +MAPK3 ERK1 P27361 human TTK 398219 Q98T92 ttk frog S844 467281 GQLIGLNsPNSISRA X +MAPK3 ERK1 P27361 human CAPN2 12334 O08529 Capn2 mouse S50 451162 GALFQDPsFPALPSS Peptidase_C2 X +MAPK3 ERK1 P27361 human PML iso4 5371 P29590-4 PML human T28 451468 PTMPPPEtPSEGRQP X +MAPK3 ERK1 P27361 human CREM 1390 Q03060 CREM human S277 450066 AsPGsLHsPQQLAEE X +MAPK3 ERK1 P27361 human GLE1 2733 Q53GS7 GLE1 human S99 18010022 ssAFsPAsPAtPNGT X +MAPK3 ERK1 P27361 human DUSP4 319520 Q8BFV3 Dusp4 mouse T363 15412237 ERGKAtPtPTSQFVF X X +MAPK3 ERK1 P27361 human ARHGEF2 iso2 9181 Q92974-2 ARHGEF2 human T678 449343 PGVELLLtPREPALP X +MAPK3 ERK1 P27361 human WSTF 9031 Q9UIG0 BAZ1B human S158 3215310 ksDGACDsPssDKEN X +MAPK3 ERK1 P27361 human GAB2 14389 Q9Z1S8 Gab2 mouse S591 62877800 PVPSGTNsPAPKKST X X +MAPK3 ERK1 P27361 human FHOD1 29109 Q9Y613 FHOD1 human S498 1984218 PAARtPQsPAPCVLL X +MAPK3 ERK1 P27361 human AML1 iso8 861 Q01196-8 RUNX1 human T300 454403 sPSVHPAtPIsPGRA X +MAPK3 ERK1 P27361 human Raptor 57521 Q8N122 RPTOR human S696 11315003 EKNyALPsPAttEGG X X +MAPK3 ERK1 P27361 human Tau iso8 4137 P10636-8 MAPT human S396 449081 GAEIVyKsPVVsGDt X X 9632 +MAPK3 ERK1 P27361 human ARRB1 408 P49407 ARRB1 human S412 447493 EEEDGtGsPQLNNR_ X 2416 +MAPK3 ERK1 P27361 human ERK1 5595 P27361 MAPK3 human T207 3949243 FLtEyVAtRWyrAPE Pkinase X +MAPK3 ERK1 P27361 human DUSP6 1848 Q16828 DUSP6 human S197 455266 SATDSDGsPLSNSQP X +MAPK3 ERK1 P27361 human SERT 6532 P31645 SLC6A4 human T616 7576402 IKsItPEtPTEIPCG X +MAPK3 ERK1 P27361 human CIITA 4261 P33076 CIITA human S280 471421 TVHGLPTsPDRPGsT X X +MAPK3 ERK1 P27361 human Tau iso8 4137 P10636-8 MAPT human S404 449082 PVVsGDtsPRHLsNV X 35834; 20194; 98523; 91600; 49562 +MAPK3 ERK1 P27361 human SRC-1 8648 Q15788 NCOA1 human S1185 449064 GtPPASTsPFSQLAA DUF1518 X +MAPK3 ERK1 P27361 human dystrophin 13405 P11531 Dmd mouse S3059 35542205 GPWERAIsPNkVPYY WW X +MAPK3 ERK1 P27361 human TPD52 7163 P55327 TPD52 human S40 17555377 GNssPPGsPTLQKFG X X +MAPK3 ERK1 P27361 human OLA1 67059 Q9CZ30 Ola1 mouse S232 1880539202 MVYLVNLsEkDyIRK X X +MAPK3 ERK1 P27361 human SULT4A1 25830 Q9BR01 SULT4A1 human T11 2048305 SEAEtPStPGEFESK X +MAPK3 ERK1 P27361 human BIM 10018 O43521 BCL2L11 human S69 449330 GPLAPPAsPGPFATR X X 4581; 4585 +MAPK3 ERK1 P27361 human DEPTOR 64798 Q8TB45 DEPTOR human S235 4723788 MELLNEksPsSQEtH X X +MAPK3 ERK1 P27361 human MCTS1 28985 Q9ULC4 MCTS1 human T81 26348501 REGPFYPtLRLLHkY Pre-PUA X +MAPK3 ERK1 P27361 human hnRNP E2 5094 Q15366 PCBP2 human S272 482918 FsGIEsssPEVkGyW X X +MAPK3 ERK1 P27361 human BANP 54971 Q8N9N5 BANP human T337 41301700 VkSFSRRtPNSSSYC X +MAPK3 ERK1 P27361 human SYN1 24949 P09951 Syn1 rat S62 451572 stAAPVAsPAAPsPG X X +MAPK3 ERK1 P27361 human CdGAP 12549 A6X8Z5 Arhgap31 mouse T776 456517 tPAPPPPtPLEEEPE X X +MAPK3 ERK1 P27361 human STAR 20845 P51557 Star mouse S232 2089100 VLHPLAGsPSKTKLT START X +MAPK3 ERK1 P27361 human HNF4 alpha 3172 P41235 HNF4A human S147 20510202 RRssyEDssLPsINA X +MAPK3 ERK1 P27361 human Tau iso8 4137 P10636-8 MAPT human S262 447930 NVKskIGstENLkHQ Tubulin-binding X +MAPK3 ERK1 P27361 human TAL2 6887 Q16559 TAL2 human S100 10425400 LENYQVPsPGPSHHI X +MAPK3 ERK1 P27361 human SMAD4 4089 Q13485 SMAD4 human T277 449628 GSRtAPYtPNLPHHQ X +MAPK3 ERK1 P27361 human HNF4 alpha 3172 P41235 HNF4A human S313 449926 GkIkRLRsQVQVsLE Hormone_recep X +MAPK3 ERK1 P27361 human DUSP4 319520 Q8BFV3 Dusp4 mouse S395 15412246 LHsPITTsPSC____ X X +MAPK3 ERK1 P27361 human BTG2 12227 Q04211 Btg2 mouse S147 455911 QMMLGRSsPsKNYVM X +MAPK3 ERK1 P27361 human MLK3 4296 Q16584 MAP3K11 human S758 448611 GtPGtPRsPPLGLIS X +MAPK3 ERK1 P27361 human Trap170 9282 O60244 MED14 human S986 452549 NEDDNPPsPIGGDMM X +MAPK3 ERK1 P27361 human hnRNP K 3190 P61978 HNRNPK human S284 448185 rrDyDDMsPrrGPPP X X +MAPK3 ERK1 P27361 human FOXO3A 2309 O43524 FOXO3 human S294 472326 QLskWPGsPtsRsSD X 5538 +MAPK3 ERK1 P27361 human SHARPIN 81858 Q9H0F6 SHARPIN human T309 1879811806 APREAPAtGPsPQHP X +MAPK3 ERK1 P27361 human palladin 23022 Q8WX93 PALLD human S808 22826102 PPPPPVFsPTAAFPV X X +MAPK3 ERK1 P27361 human Fos 14281 P01101 Fos mouse S32 470080 DSLSYYHsPADSFSS X 5348; 8709; 8677; 99325 +MAPK3 ERK1 P27361 human MEK1 5604 Q02750 MAP2K1 human T292 448287 EtPPRPRtPGRPLss Pkinase X X 26975 +MAPK3 ERK1 P27361 human Kv4.2 Q63881 Kcnd2 rat S616 457613 EGDDRPEsPEYSGGN X +MAPK3 ERK1 P27361 human TH 7054 P07101 TH human S62 448544 SYTPTPRsPRFIGRR TOH_N X +MAPK3 ERK1 P27361 human ASB2 51676 Q96Q27 ASB2 human S371 29618900 RIRRSGVsPLHLAAE Ank_2 X +MAPK3 ERK1 P27361 human p90RSK 6195 Q15418 RPS6KA1 human S380 447990 HQLFRGFsFVAtGLM Pkinase_C X 9341; 9335; 13575; 11989; 12032; 75266; 93317; 13397; 13588 +MAPK3 ERK1 P27361 human FRA2 2355 P15408 FOSL2 human T322 14573760 SDsLNsPtLLAL___ X +MAPK3 ERK1 P27361 human CAD 101843763 P08955 Cad hamster T456 451248 KVYFLPItPHYVTQV X +MAPK3 ERK1 P27361 human STMN1 3925 P16949 STMN1 human S25 448555 QAFELILsPrskEsV Stathmin X +MAPK3 ERK1 P27361 human NUP50 10762 Q9UKX7 NUP50 human S315 4957816 TQSkPVSsPFPTkPL X X +MAPK3 ERK1 P27361 human BRAF 673 P15056 BRAF human T753 460657 yACAsPKtPIQAGGy X +MAPK3 ERK1 P27361 human PML iso4 5371 P29590-4 PML human S527 451472 PHLDGPPsPRsPVIG DUF3583 X +MAPK3 ERK1 P27361 human smMLCK 4638 Q15746 MYLK human S1779 468782 sstGsPtsPLNAEKL X +MAPK3 ERK1 P27361 human LRP6 4040 O75581 LRP6 human S1490 456289 AILNPPPsPAtERsH X X 2568 +MAPK3 ERK1 P27361 human capicua 23152 Q96RK0 CIC human S1389 4952030 sPRAILGsYRKKRKN X +MAPK3 ERK1 P27361 human SP3 6670 Q02447 SP3 human S73 1199100 CsKIGPPsPGDDEEE X +MAPK3 ERK1 P27361 human KIBRA 23286 Q8IX03 WWC1 human S548 30312500 SsPSPPCsPLMADPL X X +MAPK3 ERK1 P27361 human FGFR1 2260 P11362 FGFR1 human S777 2721300 SMPLDQysPsFPDTR X X +MAPK3 ERK1 P27361 human SYN1 24949 P09951 Syn1 rat S549 451574 PAARPPAsPsPQRQA X +MAPK3 ERK1 P27361 human GSK3B 2932 P49841 GSK3B human T43 456221 kVTTVVAtPGQGPDR X +MAPK3 ERK1 P27361 human Lck 3932 P06239 LCK human S59 447820 EGSNPPAsPLQDNLV X +MAPK3 ERK1 P27361 human LIFR 3977 P42702 LIFR human S1044 450385 WNLVsPDsPRsIDSN X X +MAPK3 ERK1 P27361 human BAG3 9531 O95817 BAG3 human S377 452222 PVPCPPPsPGPsAVP X +MAPK3 ERK1 P27361 human Cortactin 2017 Q14247 CTTN human S405 447700 KtQtPPVsPAPQPtE X X +MAPK3 ERK1 P27361 human RRas2 22800 P62070 RRAS2 human S186 484150 QEQECPPsPEPtRkE X X +MAPK3 ERK1 P27361 human PDE4D iso2 5144 Q08499-2 PDE4D human S579 451090 YQSTIPQsPSPAPDD X X +MAPK3 ERK1 P27361 human MARS 4141 P56192 MARS1 human S209 27452641 LQkQPQPsPAEGRAV X X +MAPK3 ERK1 P27361 human SHARPIN 81858 Q9H0F6 SHARPIN human S165 3245774 PEADLPRsPGNLtER X X +MAPK3 ERK1 P27361 human Caldesmon iso4 800 Q05682-4 CALD1 human S534 448466 QSVDKVTsPTKV___ X +MAPK3 ERK1 P27361 human TCF8 25705 Q62947 Zeb1 rat T867 469215 DQNDSDCtPPKKKTR X +MAPK3 ERK1 P27361 human Fos 2353 P01100 FOS human T331 448484 CtPVVTCtPSCTAYT X +MAPK3 ERK1 P27361 human MCR 4306 P08235 NR3C2 human S263 18503884 NVGsPLssPLSSMKS X X +MAPK3 ERK1 P27361 human smMLCK 4638 Q15746 MYLK human S947 4739853 EEERKVHsPQQVDFR X +MAPK3 ERK1 P27361 human HNF4 alpha 3172 P41235 HNF4A human S262 63076100 CPELAEMsRVsIRIL Hormone_recep X +MAPK3 ERK1 P27361 human MCR 4306 P08235 NR3C2 human S227 25692900 FGSFPVHsPITQGTP X X +MAPK3 ERK1 P27361 human SMAD2 4087 Q15796 SMAD2 human S250 448795 TGsPAELsPTTLsPV X X 3104 +MAPK3 ERK1 P27361 human FAM195B 348262 C9JLW8 MCRIP1 human T30 9322247 PsSsEIFtPAHEENV FAM195 X +MAPK3 ERK1 P27361 human p90RSK 81771 Q63531 Rps6ka1 rat S363 447989 TSRtPRDsPGIPPsA Pkinase_C X 9344 +MAPK3 ERK1 P27361 human AML3 860 Q13950 RUNX2 human S43 10892805 PGKMSDVsPVVAAQQ X +MAPK3 ERK1 P27361 human GTF2I iso2 2969 P78347-2 GTF2I human S633 452350 QsPKRPRsPGSNSKV X X +MAPK3 ERK1 P27361 human PPAR-gamma 19016 P37238 Pparg mouse S112 448062 AIkVEPAsPPYYSEK X +MAPK3 ERK1 P27361 human DHPS 1725 P49366 DHPS human S233 1870426002 KNHIPVFsPALTDGS DS X X +MAPK3 ERK1 P27361 human GAB2 14389 Q9Z1S8 Gab2 mouse S614 12097630 DFQPGsPsPHRKPst X X +MAPK3 ERK1 P27361 human SPHK2 56848 Q9NRA0 SPHK2 human T614 477182 AFRLEPLtPRGVLTV YegS_C X X +MAPK3 ERK1 P27361 human STIM1 20866 P70302 Stim1 mouse S608 3195758 PSVPPGGsPLLDSSH X X +MAPK3 ERK1 P27361 human p53 7157 P04637 TP53 human S392 447535 FktEGPDsD______ X 9281 +MAPK3 ERK1 P27361 human Tau iso8 4137 P10636-8 MAPT human T153 449076 DGKtKIAtPRGAAPP X +MAPK3 ERK1 P27361 human DUSP1 1843 P28562 DUSP1 human S359 448660 SALSYLQsPITTsPS X X 2857 +MAPK3 ERK1 P27361 human MZF-1 109889 O70162 Mzf1 mouse S374 448856 SLSGQIQsPTTEGGF X +MAPK3 ERK1 P27361 human PTP-SL iso2 19279 Q62132-2 Ptprr mouse T253 450119 EPFVAVStPREKVAM X +MAPK3 ERK1 P27361 human AR 367 P10275 AR human S651 448414 GEASSTTsPTEETTQ X +MAPK3 ERK1 P27361 human CIITA 4261 P33076 CIITA human S288 2286408 PDRPGsTsPFAPsAT X +MAPK3 ERK1 P27361 human OLA1 67059 Q9CZ30 Ola1 mouse Y236 1880539204 VNLsEkDyIRKKNKW X +MAPK3 ERK1 P27361 human STMN1 3925 P16949 STMN1 human S38 448556 sVPEFPLsPPkKkDL Stathmin X 3426; 4191 +MAPK3 ERK1 P27361 human TTK 7272 P33981 TTK human S821 467281 GQLVGLNsPNsILkA X +MAPK3 ERK1 P27361 human NUP50 10762 Q9UKX7 NUP50 human S221 476622 kVAAEtQsPsLFGst X X +MAPK3 ERK1 P27361 human STAT3 6774 P40763 STAT3 human S727 448191 NtIDLPMsPrTLDSL X 9134; 9136; 34911; 94994; 49081; 58978; 87544; 71958; 50804 +MAPK3 ERK1 P27361 human eplin 65970 Q9ERG0 Lima1 mouse S692 460654 NHVHAQQsPLEPEAP X X +MAPK3 ERK1 P27361 human Fos 314322 P12841 Fos rat S374 448482 PSSDSLSsPTLLAL_ X +MAPK3 ERK1 P27361 human FOXO3A 2309 O43524 FOXO3 human S425 2058400 TKGsGLGsPtSSFNS X 64616 +MAPK3 ERK1 P27361 human PIP5K1C 23396 O60331 PIP5K1C human S650 457599 DERSWVysPLHYSAQ X +MAPK3 ERK1 P27361 human HSP75 10131 Q12931 TRAP1 human S511 55374803 NrHLAEHsPyyEAMk HSP90 X +MAPK3 ERK1 P27361 human myocardin 214384 Q8VIM5 Myocd mouse S812 10791200 EVLLNSHsPIGKVSD X X +MAPK3 ERK1 P27361 human RAB3IP 29885 Q62739 Rab3ip rat S250 482771 VLSSsPTsPTQEPLA Sec2p X +MAPK3 ERK1 P27361 human PR 18667 Q00175 Pgr mouse S294 447987 SPIAPGRsPLATTVV Prog_receptor X 13736 +MAPK3 ERK1 P27361 human CACNA1B 100008979 Q05152 CACNA1B rabbit S411 459047 DRNAEEKsPLDAVLK X +MAPK3 ERK1 P27361 human NPAS4 225872 Q8BGD7 Npas4 mouse T423 1871095704 LSKDLVCtPPYtPHQ X +MAPK3 ERK1 P27361 human LIN28A 83557 Q8K3Y3 Lin28a mouse S200 7231811 EEEEEIHsPALLPEA X X +MAPK3 ERK1 P27361 human SP1 6667 P08047 SP1 human T739 448227 sEGSGtAtPSALITT X X +MAPK3 ERK1 P27361 human hnRNP E2 5094 Q15366 PCBP2 human T213 482919 SASFPHTtPSMCLNP X X +MAPK3 ERK1 P27361 human hnRNP K 3190 P61978 HNRNPK human S353 450147 DSAIDTWsPSEWQMA X +MAPK3 ERK1 P27361 human HNF4 alpha 3172 P41235 HNF4A human S138 20510206 QNERDRIstRRssyE X +MAPK3 ERK1 P27361 human TR-beta1 7068 P10828 THRB human S142 449635 IQKNLHPsYSCkYEG zf-C4 X X +MAPK3 ERK1 P27361 human STIM1 20866 P70302 Stim1 mouse S621 3635048 SHSLSPSsPDPDTPs X X +MAPK3 ERK1 P27361 human AML3 860 Q13950 RUNX2 human S24 10892806 FFWDPSTsRRFsPPS X +MAPK3 ERK1 P27361 human OSBP2 23762 Q969R2 OSBP2 human S762 11171320 ECSKVMHssPssPsS Oxysterol_BP X +MAPK3 ERK1 P27361 human CACNB1 50688 P54283 Cacnb1 rat S161 459045 CEVGFIPsPVKLDSL X +MAPK3 ERK1 P27361 human Symplekin 8189 Q92797 SYMPK human T1257 3208452 VGEDAMKtPsPAAED X +MAPK3 ERK1 P27361 human PAP-alpha 18789 Q61183 Papola mouse S537 1737605 DNSMSVPsPTSAMKT X X +MAPK3 ERK1 P27361 human TH iso3 7054 P07101-3 TH human S31 448544 KQAEAIMsPRFIGRR TOH_N X +MAPK3 ERK1 P27361 human NPAS4 225872 Q8BGD7 Npas4 mouse S615 1871095701 GLLtPEAsPVKQSFF X +MAPK3 ERK1 P27361 human GRHL1 29841 Q9NZI5 GRHL1 human S76 3252757 KVPRERRssTAKPEV X +MAPK3 ERK1 P27361 human SMAD2 4087 Q15796 SMAD2 human S245 448794 NQsMDTGsPAELsPT X X 3104 +MAPK3 ERK1 P27361 human E2F4 1874 Q16254 E2F4 human S384 4763386 FAPLLRLsPPPGDHD X X +MAPK3 ERK1 P27361 human TRPV3 162514 Q8NET8 TRPV3 human T264 334535805 EGFYFGEtPLALAAC Ank X +MAPK3 ERK1 P27361 human NUP153 9972 P49790 NUP153 human T369 3191104 PPVQRLMtPKPVsIA Nup153 X +MAPK3 ERK1 P27361 human Bcl-6 604 P41182 BCL6 human S333 447600 KGLVsPQsPQKsDCQ X +MAPK3 ERK1 P27361 human HNF4 alpha 3172 P41235 HNF4A human T469 458373 AIPQPtItKQEVI__ X +MAPK3 ERK1 P27361 human Abi-1 10006 Q8IZP0 ABI1 human S183 486178 PPtQKPPsPPMsGRG X +MAPK3 ERK1 P27361 human SYN1 24949 P09951 Syn1 rat S67 451573 VAsPAAPsPGSSGGG X X +MAPK3 ERK1 P27361 human p21Cip1 1026 P38936 CDKN1A human S98 478193 GGRRPGTsPALLQGT X +MAPK3 ERK1 P27361 human STMN1 396057 P31395 STMN1 chicken S38 448556 AAPEFPLsPPKKKDL Stathmin X +MAPK3 ERK1 P27361 human CdGAP 12549 A6X8Z5 Arhgap31 mouse T769 1791606 RNLsPPLtPAPPPPt X +MAPK3 ERK1 P27361 human CTNND1 1500 O60716 CTNND1 human T310 450457 GtARRtGtPsDPRRR X +MAPK3 ERK1 P27361 human ERK5 5598 Q13164 MAPK7 human T733 455520 LPPVFsGtPKGSGAG X +MAPK3 ERK1 P27361 human Abi-1 10006 Q8IZP0 ABI1 human S225 1983922 ARLGsQHsPGRtAsL X +MAPK3 ERK1 P27361 human BRAF 673 P15056 BRAF human S151 478631 VARsNPKsPQKPIVR X +MAPK3 ERK1 P27361 human DUSP5 1847 Q16690 DUSP5 human T321 10206802 ESEILPStPNPQPPS X +MAPK3 ERK1 P27361 human HSPB8 26353 Q9UJY1 HSPB8 human T87 467970 GVPAEGRtPPPFPGE X +MAPK3 ERK1 P27361 human YTHDF2 51441 Q9Y5A9 YTHDF2 human S39 483929 DDFEPyLsPQARPNN X X +MAPK3 ERK1 P27361 human CRYAB 12955 P23927 Cryab mouse S45 448748 FSTATSLsPFYLRPP Crystallin X +MAPK3 ERK1 P27361 human OSBP2 23762 Q969R2 OSBP2 human S766 15721694 VMHssPssPsSDGKQ Oxysterol_BP X +MAPK3 ERK1 P27361 human PML iso4 5371 P29590-4 PML human S530 451473 DGPPsPRsPVIGsEV DUF3583 X +MAPK3 ERK1 P27361 human STAT3 20848 P42227 Stat3 mouse S727 448191 NtIDLPMsPRTLDSL X 9134; 9136; 34911; 94994; 49081; 58978; 87544; 71958; 50804 +MAPK3 ERK1 P27361 human SREBP-2 6721 Q12772 SREBF2 human S432 451007 NQNVLLMsPPASDSG X X +MAPK3 ERK1 P27361 human AML3 860 Q13950 RUNX2 human S314 10892801 LSQMTsPsIHSTTPL X +MAPK3 ERK1 P27361 human GLE1 2733 Q53GS7 GLE1 human T102 472369 FsPAsPAtPNGTKGk X +MAPK3 ERK1 P27361 human SRC-2 10499 Q15596 NCOA2 human S736 465446 tIkQEPVsPkkKENA DUF4927 X +MAPK3 ERK1 P27361 human SREBP-1 6720 P36956 SREBF1 human S117 469986 YPSMPAFsPGPGIkE X X +MAPK3 ERK1 P27361 human FOXO3A 2309 O43524 FOXO3 human S12 9318037 PAsPAPLsPLEVELD X +MAPK3 ERK1 P27361 human DUSP4 1846 Q13115 DUSP4 human S386 15412243 SSLPYLHsPITTsPS X +MAPK3 ERK1 P27361 human GLRA1 14654 Q64018 Glra1 mouse S408 1869137000 PPPAPSKsPEEMRkL X +MAPK3 ERK1 P27361 human GR 2908 P04150 NR3C1 human S226 451796 IDENCLLsPLAGEDD GCR X 97285 +MAPK3 ERK1 P27361 human TMEM55B 219024 Q3TWL2 Pip4p1 mouse S76 4717517 GEDPPPYsPLTsPDs Tmemb_55A X +MAPK3 ERK1 P27361 human E2F4 1874 Q16254 E2F4 human S244 28843800 QEASRPNsPQLTPTA X X +MAPK3 ERK1 P27361 human AML3 860 Q13950 RUNX2 human S503 3053613 ADGsHSSsPTVLNSS RunxI X +MAPK3 ERK1 P27361 human eplin 51474 Q9UHB6 LIMA1 human S604 459750 FQstsVKsPKtVsPP X +MAPK3 ERK1 P27361 human Abi-1 10006 Q8IZP0 ABI1 human S267 18715503 PIAVPtPsPPTIGPE X +MAPK3 ERK1 P27361 human myocardin 214384 Q8VIM5 Myocd mouse S859 10791202 ELLPGPLsPMHAQLs X X +MAPK3 ERK1 P27361 human HNF4 alpha 3172 P41235 HNF4A human T166 15501727 EVLSRQItsPVsGIN X +MAPK3 ERK1 P27361 human KSR 16706 Q61097 Ksr1 mouse S443 449300 TTSSTPSsPAPFLTS X +MAPK3 ERK1 P27361 human N-Myc 4613 P04198 MYCN human S62 448222 LLPtPPLsPsrGFAE Myc_N X +MAPK3 ERK1 P27361 human AML1 iso8 861 Q01196-8 RUNX1 human S303 454401 VHPAtPIsPGRASGM X +MAPK3 ERK1 P27361 human Bcl-2 596 P10415 BCL2 human S87 448396 AAAGPALsPVPPVVH X +MAPK3 ERK1 P27361 human p27Kip1 1027 P46527 CDKN1B human T187 447875 NAGsVEQtPKKPGLR X +MAPK3 ERK1 P27361 human Tau iso8 4137 P10636-8 MAPT human S46 447926 tDAGLkEsPLQtPtE X 20296 +MAPK3 ERK1 P27361 human NFAT3 4776 Q14934 NFATC4 human S676 455348 SNGRRKRsPTQSFRF RHD_dimer X X +MAPK3 ERK1 P27361 human MCR 4306 P08235 NR3C2 human S361 25692903 TLRDVVPsPDTQEKG X X +MAPK3 ERK1 P27361 human MBP 4155 P02686 MBP human T232 450929 KNIVTPRtPPPSQGK Myelin_MBP X +MAPK3 ERK1 P27361 human WAVE2 10163 Q9Y6W5 WASF2 human S351 18715500 PGtPPPPsPPSFPPH X +MAPK3 ERK1 P27361 human TOP2A 7153 P11388 TOP2A human S1361 455094 sPPKTKtsPKLsNkE X +MAPK3 ERK1 P27361 human MCL1 4170 Q07820 MCL1 human T92 4825134 EVPDVTAtPARLLFF X +MAPK3 ERK1 P27361 human HER2 2064 P04626 ERBB2 human T701 472481 TELVEPLtPsGAMPN X +MAPK3 ERK1 P27361 human 4E-BP1 1978 Q13541 EIF4EBP1 human S65 447527 FLMECrNsPVtktPP eIF_4EBP X 9451; 9456; 13443 +MAPK3 ERK1 P27361 human SMAD2 Q1W668 SMAD2 cow S255 448796 ELsPTTLsPVNHSLD X +MAPK3 ERK1 P27361 human C/EBP-alpha 1050 P49715 CEBPA human S21 448308 PMsSHLQsPPHAPSS X X 2841 +MAPK3 ERK1 P27361 human Caldesmon 281660 NP_776683 CALD1 cow S531 448466 QSVDKVTsPTKV___ X +MAPK3 ERK1 P27361 human HER4 2066 Q15303 ERBB4 human S1051 1869951802 NRSEIGHsPPPAyTP X +MAPK3 ERK1 P27361 human DUSP6 67603 Q9DBB1 Dusp6 mouse S159 455265 DGSCSSSsPPLPVLG X +MAPK3 ERK1 P27361 human NUP153 9972 P49790 NUP153 human S516 3191083 TNKVQMtsPsstGsP Nup153 X +MAPK3 ERK1 P27361 human RAB3IP 29885 Q62739 Rab3ip rat S247 2023489 KTLVLSSsPTsPTQE Sec2p X +MAPK3 ERK1 P27361 human Tau iso8 4137 P10636-8 MAPT human S202 447928 sGyssPGsPGtPGsR X 39357; 30505 +MAPK3 ERK1 P27361 human RAF1 5894 P04049 RAF1 human S289 455311 RsHsEsAsPsALsss X X 9431 +MAPK3 ERK1 P27361 human DUSP5 1847 Q16690 DUSP5 human S376 10206801 TVSELSRsPVATATS X +MAPK3 ERK1 P27361 human NUP153 9972 P49790 NUP153 human S257 3191077 ktsQLGDsPFyPGkT Nup153 X +MAPK3 ERK1 P27361 human HNF4 alpha 3172 P41235 HNF4A human S95 63076102 VRKNHMYsCRFsRQC zf-C4 X +MAPK3 ERK1 P27361 human PKM 5315 P14618 PKM human S37 476070 MCRLDIDsPPItARN X +MAPK3 ERK1 P27361 human METTL3 56339 Q86U44 METTL3 human S43 483736 rNPEAALsPTFRsDs X +MAPK3 ERK1 P27361 human PXN iso2 5829 P49023-2 PXN human S130 450228 KQKsAEPsPtVMSts Paxillin X +MAPK3 ERK1 P27361 human MAZ 4150 P56270 MAZ human T72 451250 AAPAPPPtPQAPAAE X X +MAPK3 ERK1 P27361 human Caldesmon 800 Q05682 CALD1 human S759 448465 ktPDGNksPAPKPsD Caldesmon X +MAPK3 ERK1 P27361 human HIF2A 2034 Q99814 EPAS1 human S672 56668652 APLGPPVsPPHVSTF X X +MAPK3 ERK1 P27361 human STIM1 20866 P70302 Stim1 mouse S575 468876 LVEKLPDsPALAKKT X X +MAPK3 ERK1 P27361 human p21Cip1 1026 P38936 CDKN1A human S130 455618 sGEQAEGsPGGPGDs X +MAPK3 ERK1 P27361 human FRA2 2355 P15408 FOSL2 human S320 4707550 QSSDsLNsPtLLAL_ X +MAPK3 ERK1 P27361 human BAD 572 Q92934 BAD human S75 447860 EIRsRHssyPAGtED Bcl-2_BAD X 9291; 5284; 9296; 5193; 11865; 94223 +MAPK3 ERK1 P27361 human RXRA 6256 P19793 RXRA human S260 450891 NMGLNPssPNDPVtN Hormone_recep X X +MAPK3 ERK1 P27361 human NUP153 9972 P49790 NUP153 human S338 468337 IVssPLNsPLDrsGI Nup153 X +MAPK3 ERK1 P27361 human palladin 23022 Q8WX93 PALLD human S688 18013438 APRsAPPsPPFPPPP X X +MAPK3 ERK1 P27361 human BIK 12124 O70337 Bik mouse T116 25171001 IWSWRVLtPGAWVSP bcl-2I13 X +MAPK3 ERK1 P27361 human SRm300 75956 Q8BTI8 Srrm2 mouse S1068 453278 GsLsRsssPVtELtA X +MAPK3 ERK1 P27361 human HDAC6 10013 Q9UBN7 HDAC6 human S1035 29604201 DHQtPPtsPVQGttP X +MAPK3 ERK1 P27361 human eIF4G iso8 1981 Q04637-8 EIF4G1 human S1232 449798 EAALPPVsPLKAALs X +MAPK3 ERK1 P27361 human RAB3IP 29885 Q62739 Rab3ip rat S19 37039803 VNLAsPTsPDLLGVC X +MAPK3 ERK1 P27361 human KLF4 16600 Q60793 Klf4 mouse S132 24976100 ASASSSSsPASSGPA X +MAPK3 ERK1 P27361 human PLCB1 23236 Q9NQ66 PLCB1 human S982 4787475 KkKsEPssPDHGssT X X +MAPK3 ERK1 P27361 human CAPN2 824 P17655 CAPN2 human S50 451162 GTLFQDPsFPAIPSA Peptidase_C2 X X +MAPK3 ERK1 P27361 human ER-alpha 2099 P03372 ESR1 human S118 448101 LHPPPQLsPFLQPHG Oest_recep X X 2511 +MAPK3 ERK1 P27361 human MKL1 57591 Q969V6 MRTFA human S454 467355 tGstPPVsPtPsERS X +MAPK3 ERK1 P27361 human GRK2 282682 P21146 GRK2 cow S670 447725 KMKNKPRsPVVELSK X +MAPK3 ERK1 P27361 human supervillin Q6U1J6 SVIL ferret S132 7721700 DSEADSEsPSRYTKS X X +MAPK3 ERK1 P27361 human NIPA 232679 Q80YV2 Zc3hc1 mouse S358 483339 tRsWEsssPVDRPEL X +MAPK3 ERK1 P27361 human METTL3 56339 Q86U44 METTL3 human S525 1871246003 YGMIERLsPGTRKIE MT-A70 X +MAPK3 ERK1 P27361 human GAB1 14388 Q9QYY0 Gab1 mouse S552 454074 ELQAPVRsPITRSFA X +MAPK3 ERK1 P27361 human DUSP4 319520 Q8BFV3 Dusp4 mouse T361 25123903 LRERGKAtPtPTSQF X X +MAPK3 ERK1 P27361 human GABRA1 29705 P62813 Gabra1 rat T375 471418 APTATSytPNLARGD X +MAPK3 ERK1 P27361 human PDE4D iso6 24627 P14270-6 Pde4d rat S585 451090 YQSTIPQsPSPAPDD X +MAPK3 ERK1 P27361 human NUP153 9972 P49790 NUP153 human S320 4747698 QsLEkMssPLADAkR Nup153 X +MAPK3 ERK1 P27361 human ER-alpha 2099 P03372 ESR1 human S106 448100 PLNsVsPsPLMLLHP Oest_recep X +MAPK3 ERK1 P27361 human 5-LO 240 P09917 ALOX5 human S664 461913 QLPYYYLsPDRIPNs X 3749 +MAPK3 ERK1 P27361 human DUSP4 319520 Q8BFV3 Dusp4 mouse S390 15412243 SNLPYLHsPITTsPS X X +MAPK3 ERK1 P27361 human capicua 23152 Q96RK0 CIC human S1409 453485 sAPEDPtsPKRKMRR X +MAPK3 ERK1 P27361 human p47phox 653361 P14598 NCF1 human S345 451727 QARPGPQsPGsPLEE X X +MAPK3 ERK1 P27361 human mGluR5 108071 Q3UVX5 Grm5 mouse S1158 25581600 LVALtPPsPFRDSVD GluR_Homer-bdg X +MAPK3 ERK1 P27361 human WTAP 9589 Q15007 WTAP human T148 36131377 ELSAWkFtPDSQTGK Wtap X +MAPK3 ERK1 P27361 human Oct4 5460 Q01860 POU5F1 human S111 25236703 EsNsDGAsPEPCtVt X +MAPK3 ERK1 P27361 human Cofilin-1 12631 P18760 Cfl1 mouse T25 7990494 MkVRKSstPEEVKkR Cofilin_ADF X +MAPK3 ERK1 P27361 human MLK3 4296 Q16584 MAP3K11 human S705 448610 FSLKtPDsPPtPAPL X +MAPK3 ERK1 P27361 human DUSP6 67603 Q9DBB1 Dusp6 mouse S197 455266 SATDSDGsPLSNSQP X +MAPK3 ERK1 P27361 human TOB1 10140 P50616 TOB1 human S152 455535 PASSVSSsPsPPFGH X X +MAPK3 ERK1 P27361 human Tau iso8 4137 P10636-8 MAPT human T217 449078 sRtPsLPtPPtREPK X 33134; 51625 +MAPK3 ERK1 P27361 human HNF4 alpha 3172 P41235 HNF4A human T467 63076104 LsAIPQPtItKQEVI X +MAPK3 ERK1 P27361 human CDCA5 113130 Q96FF9 CDCA5 human S209 3208965 DMtLPGIsPPPEKQK Sororin X +MAPK3 ERK1 P27361 human RPS3 6188 P23396 RPS3 human T42 455909 sGVEVRVtPTRtEII KH_2 X X +MAPK3 ERK1 P27361 human BIM 64547 O88498 Bcl2l11 rat S65 449330 GPLAPPAsPGPFATR X X 4581; 4585 +MAPK3 ERK1 P27361 human PXN 360820 Q66H76 Pxn rat S130 450228 KQKsAEPsPtVMSss Paxillin X X +MAPK3 ERK1 P27361 human XBP1 7494 P17861 XBP1 human S68 21688102 RQRLTHLsPEEkALR bZIP_2 X +MAPK3 ERK1 P27361 human eplin 65970 Q9ERG0 Lima1 mouse S360 455424 PMHPKPLsPDARTSs X X +MAPK3 ERK1 P27361 human TWIST1 7291 Q15672 TWIST1 human S68 18905000 GGGDEPGsPAQGkRG X X +MAPK3 ERK1 P27361 human CTNND1 1500 O60716 CTNND1 human T308 3651652 DyGtARRtGtPsDPR X +MAPK3 ERK1 P27361 human DUSP1 1843 P28562 DUSP1 human S364 448661 LQsPITTsPSC____ X X +MAPK3 ERK1 P27361 human ARHGEF2 iso2 9181 Q92974-2 ARHGEF2 human S959 467500 SRLSPPHsPRDFTRM X X +MAPK3 ERK1 P27361 human BAG3 9531 O95817 BAG3 human T285 467534 GsPARsstPLHsPsP X +MAPK3 ERK1 P27361 human Tau iso8 4137 P10636-8 MAPT human T50 447931 LkEsPLQtPtEDGsE X +MAPK3 ERK1 P27361 human Tel 2120 P41212 ETV6 human S213 451376 DNMIRRLsPAERAQG X X +MAPK3 ERK1 P27361 human RAB5A 5868 P20339 RAB5A human S123 457391 kELQRQAsPNIVIAL Ras X +MAPK3 ERK1 P27361 human AML1 iso8 861 Q01196-8 RUNX1 human S462 454402 AEGSHSNsPTNMAPS RunxI X +MAPK3 ERK1 P27361 human MED1 5469 Q15648 MED1 human T1457 449866 HsKsPAytPQNLDsE X +MAPK3 ERK1 P27361 human ARHGEF2 9181 Q92974 ARHGEF2 human T679 449343 PGVELLLtPREPALP X +MAPK3 ERK1 P27361 human MSK1 9252 O75582 RPS6KA5 human S360 448215 TEMDPTYsPAALPQS Pkinase_C X 9594 +MAPK3 ERK1 P27361 human NPAS4 225872 Q8BGD7 Npas4 mouse T611 1871095703 LVPEGLLtPEAsPVK X +MAPK3 ERK1 P27361 human SMAD2 4087 Q15796 SMAD2 human T8 448792 MsSILPFtPPVVkRL X X +MAPK3 ERK1 P27361 human SEC16A 9919 O15027 SEC16A human T593 455894 GsVsQPstPsPPKPt X X +MAPK3 ERK1 P27361 human CBX7 52609 Q8VDS3 Cbx7 mouse T119 29669800 TNGPPPWtPTLPSSE CBX7_C X +MAPK3 ERK1 P27361 human SPHK2 56848 Q9NRA0 SPHK2 human S387 477181 PATVEPAsPTPAHSL X X +MAPK3 ERK1 P27361 human Jun 3725 P05412 JUN human S73 447943 VGLLkLAsPELERLI Jun X X 9164; 3270; 8752; 12714; 77955 +MAPK3 ERK1 P27361 human MEK1 5604 Q02750 MAP2K1 human T286 448286 VEGdAAEtPPRPRtP Pkinase X X 9127 +MAPK3 ERK1 P27361 human HSF1 3297 Q00613 HSF1 human S307 449046 EPPsPPQsPRVEEAs Vert_HS_TF X +MAPK3 ERK1 P27361 human FBXW7 55294 Q969H0 FBXW7 human S176 25126709 KRKLDHGsEVRSFSL X X +MAPK3 ERK1 P27361 human HSF4 3299 Q9ULV5 HSF4 human S298 4037600 LLkEEPAsPGGDGEA X X +MAPK3 ERK1 P27361 human eplin 65970 Q9ERG0 Lima1 mouse S602 459750 FRTSsIKsPKAssPS X X +MAPK3 ERK1 P27361 human FRA2 14284 P47930 Fosl2 mouse S320 4707550 QSSDSLNsPtLLAL_ X +MAPK3 ERK1 P27361 human METTL3 56339 Q86U44 METTL3 human S50 3204585 sPTFRsDsPVPtAPt X +MAPK3 ERK1 P27361 human USP11 8237 P51784 USP11 human S948 466974 GssGAPAsPACssPP X +MAPK3 ERK1 P27361 human EPS8 13860 Q08509 Eps8 mouse S624 7101206 ADtPsAPsPPPtPAP X +MAPK3 ERK1 P27361 human Abi-1 10006 Q8IZP0 ABI1 human T394 12626406 ENIADsPtPPPPPPP X +MAPK3 ERK1 P27361 human FAM195B 348262 C9JLW8 MCRIP1 human S21 486127 kRtssPRsPPsSsEI FAM195 X +MAPK3 ERK1 P27361 human TACE 11491 Q9Z0F8 Adam17 mouse T735 449804 kPFPAPQtPGRLQAL X +MAPK3 ERK1 P27361 human NUP153 9972 P49790 NUP153 human S529 452707 sPMFKFSsPIVKsTE Nup153 X X +MAPK3 ERK1 P27361 human GTF2I iso2 2969 P78347-2 GTF2I human S627 452349 INTKALQsPKRPRsP X X +MAPK3 ERK1 P27361 human HSPB8 26353 Q9UJY1 HSPB8 human S27 7994902 PFRDsPLsSRLLDDG X +MAPK3 ERK1 P27361 human CASP8 841 Q14790 CASP8 human S387 16855100 yLEMDLSsPQTRYIP Peptidase_C14 X +MAPK3 ERK1 P27361 human Bcl-2 12043 P10417 Bcl2 mouse S70 448395 RDMAARtsPLRPLVA X X +MAPK3 ERK1 P27361 human PTPRCAP 5790 Q14761 PTPRCAP human S163 4733815 EGDLVLGsPGPASAG PTPRCAP X X +MAPK3 ERK1 P27361 human NCKIPSD 51517 Q9NZQ3 NCKIPSD human T242 1868827200 PGSSCSPtPPPVPRr X X +MAPK3 ERK1 P27361 human Raptor 57521 Q8N122 RPTOR human S863 453732 LtQsAPAsPtNkGVH X X +MAPK3 ERK1 P27361 human STAT5A 6776 P42229 STAT5A human S780 448750 DsLDsRLsPPAGLFT X X +MAPK3 ERK1 P27361 human MCL1 17210 P97287 Mcl1 mouse T144 455375 ADGsLPStPPPPEEE X 4579 +MAPK3 ERK1 P27361 human Tau iso8 4137 P10636-8 MAPT human T181 447932 ktPPAPktPPssGEP X X 12885; 66224; 62672 +MAPK3 ERK1 P27361 human JunD 24518 P52909 Jund rat S100 456168 LGLLKLAsPELERLI Jun X 9164 +MAPK3 ERK1 P27361 human MCR 4306 P08235 NR3C2 human S287 4767239 SVKsPVSsPNNVTLR X X +MAPK3 ERK1 P27361 human STF-1 26423 P33242 Nr5a1 mouse S203 447603 EYPEPYAsPPQQPGP X +MAPK3 ERK1 P27361 human DRP1 10059 O00429 DNM1L human S616 454690 PIPIMPAsPQKGHAV X X 3455; 4494; 63940 +MAPK3 ERK1 P27361 human TAL1 6886 P17542 TAL1 human S122 450663 DGRMVQLsPPALAAP X +MAPK3 ERK1 P27361 human DNMT3A Q4W5Z4 DNMT3A chicken S220 4700048 QQPTDPAsPNVATTP X +MAPK3 ERK1 P27361 human REST 5978 Q13127 REST human S864 453739 TEDLsPPsPPLPKEN X +MAPK3 ERK1 P27361 human gephyrin 64845 Q03555 Gphn rat S281 483463 AsLSttPsEsPRAQA X +MAPK3 ERK1 P27361 human EGFR 1956 P00533 EGFR human T693 448054 RELVEPLtPsGEAPN X X 3056; 8808 +MAPK3 ERK1 P27361 human HNF4 alpha 3172 P41235 HNF4A human S142 458368 DRIstRRssyEDssL X +MAPK3 ERK1 P27361 human RAC1 5879 P63000 RAC1 human T108 27458396 VrHHCPNtPIILVGT Ras X X +MAPK3 ERK1 P27361 human NHE1 24782 P26431 Slc9a1 rat S775 475073 MIRsKEPssPGTDDV X +MAPK3 ERK1 P27361 human KARS 3735 Q15046 KARS1 human S207 9392600 PYEITLLsPCLHMLP X +MAPK3 ERK1 P27361 human MARCKS 4082 P29966 MARCKS human S46 454165 VKVNGDAsPAAAEsG MARCKS X +MAPK3 ERK1 P27361 human BAG3 9531 O95817 BAG3 human S289 469169 RsstPLHsPsPIRVH X +MAPK3 ERK1 P27361 human ATF-2 11909 P16951 Atf2 mouse T53 448225 IVADQtPtPtRFLKN X 9225; 9221; 5112; 94125; 13850; 40749; 15411; 24329; 61584; 27934; 92109; 20534; 35858 +MAPK3 ERK1 P27361 human Jun 3725 P05412 JUN human S63 447686 kNsDLLtsPDVGLLk Jun X X 5464; 9261; 2361; 97721; 91952 +MAPK3 ERK1 P27361 human NHE1 24782 P26431 Slc9a1 rat S776 475074 IRsKEPssPGTDDVF X +MAPK3 ERK1 P27361 human PML iso4 5371 P29590-4 PML human S38 451470 EGRQPsPsPsPTERA X +MAPK3 ERK1 P27361 human DUSP4 1846 Q13115 DUSP4 human S391 15412246 LHsPITTsPSC____ X +MAPK3 ERK1 P27361 human eplin 51474 Q9UHB6 LIMA1 human S374 452503 AssLsEssPPKAMKK X +MAPK3 ERK1 P27361 human CDK2 1017 P24941 CDK2 human T160 447739 GVPVRtytHEVVtLW Pkinase X 2561 +MAPK3 ERK1 P27361 human FOXO3A 2309 O43524 FOXO3 human S344 2058401 QDDDAPLsPMLYSSS X +MAPK3 ERK1 P27361 human ELK4 2005 P28324 ELK4 human S381 4317600 IHFWSTLsPVAPLsP X X +MAPK3 ERK1 P27361 human MZF-1 109889 O70162 Mzf1 mouse S354 448855 TAEPDMMsPHLHVPW X +MAPK3 ERK1 P27361 human PTP-PEST 5782 Q05209 PTPN12 human S571 1983755 KtVsLtPsPtTQVEt X X +MAPK3 ERK1 P27361 human SHOC2 8036 Q9UQ13 SHOC2 human T507 1867945200 GLGENLLtHLPEEIG LRR_8 X +MAPK3 ERK1 P27361 human Abi-1 10006 Q8IZP0 ABI1 human S392 12626405 VQENIADsPtPPPPP X +MAPK3 ERK1 P27361 human AML3 12393 Q08775 Runx2 mouse S380 10892804 DPRQAQSsPPWSYDQ X +MAPK3 ERK1 P27361 human GLRA1 2741 P23415 GLRA1 human S408 1869137000 PPPAPSKsPEEMRKL X +MAPK3 ERK1 P27361 human MCL1 4170 Q07820 MCL1 human T163 455375 tDGsLPstPPPAEEE X X 4579; 14765 +MAPK3 ERK1 P27361 human smMLCK 396445 P11799 MYLK chicken S1768 468782 AsGssPTsPINADKV X +MAPK3 ERK1 P27361 human myocardin 214384 Q8VIM5 Myocd mouse T893 10791203 TMEWLDLtPPSSTPG X X +MAPK3 ERK1 P27361 human Tau iso8 4137 P10636-8 MAPT human T175 449077 AtRIPAktPPAPktP X +MAPK3 ERK1 P27361 human Abi-1 10006 Q8IZP0 ABI1 human S216 3205884 VPNDyMtsPARLGsQ X +MAPK3 ERK1 P27361 human Abi-1 10006 Q8IZP0 ABI1 human T265 18715504 GIPIAVPtPsPPTIG X +MAPK3 ERK1 P27361 human SHC1 20416 P98083 Shc1 mouse S36 448508 TPPEELPsPSASSLG X +MAPK3 ERK1 P27361 human CACNA1B 100008979 Q05152 CACNA1B rabbit S447 459048 TGLCAPGsPFARASL X +MAPK3 ERK1 P27361 human MCR 4306 P08235 NR3C2 human S238 25692902 QGTPLTCsPNVENRG X X +MAPK3 ERK1 P27361 human HNF4 alpha 3172 P41235 HNF4A human T139 8081928 NERDRIstRRssyED X +MAPK3 ERK1 P27361 human OSBP2 23762 Q969R2 OSBP2 human S768 15721697 HssPssPsSDGKQKT Oxysterol_BP X +MAPK3 ERK1 P27361 human Ets-1 23871 P27577 Ets1 mouse T38 447950 CADVPLLtPSsKEMM X X +MAPK3 ERK1 P27361 human TOP2A 7153 P11388 TOP2A human S1354 452240 DFVPsDAsPPKTKts X +MAPK3 ERK1 P27361 human GATA4 14463 Q08369 Gata4 mouse S261 450013 IKPQRRLsASRRVGL X +MAPK3 ERK1 P27361 human HNF4 alpha 3172 P41235 HNF4A human S143 458369 RIstRRssyEDssLP X +MAPK3 ERK1 P27361 human HNF4 alpha 3172 P41235 HNF4A human S167 458371 VLSRQItsPVsGING X +MAPK3 ERK1 P27361 human Myc 4609 P01106 MYC human S77 448586 LLPtPPLsPsRRsGL Myc_N X 13748 +MAPK3 ERK1 P27361 human MAFG 4097 O15525 MAFG human S124 18011934 FARTVARsPVAPARG X X +MAPK3 ERK1 P27361 human IL2RB 3560 P14784 IL2RB human T476 41591300 PQPLGPPtPGVPDLV X +MAPK3 ERK1 P27361 human p90RSK 81771 Q63531 Rps6ka1 rat T573 447993 AENGLLMtPCYTANF Pkinase X 9346 +MAPK3 ERK1 P27361 human hnRNP E2 5094 Q15366 PCBP2 human S173 482916 MLETLSQsPPKGVtI X X +MAPK3 ERK1 P27361 human STMN1 16765 P54227 Stmn1 mouse S25 448555 QAFELILsPRskEsV Stathmin X +MAPK3 ERK1 P27361 human C/EBP-beta 12608 P28033 Cebpb mouse T188 447878 sSssPPGtPSPADAK X X 3084 +MAPK3 ERK1 P27361 human GRASP55 26003 Q9H8Y8 GORASP2 human T225 470123 QMAGtPItPLKDGFT X +MAPK3 ERK1 P27361 human MED1 5469 Q15648 MED1 human T1032 458308 SSSNRPFtPPTsTGG X +MAPK3 ERK1 P27361 human AML3 860 Q13950 RUNX2 human S340 4169883 TDVPRRIsDDDTATs X +MAPK3 ERK1 P27361 human ARRB2 409 P32121 ARRB2 human T276 50247604 FCKVYTItPLLSDNR Arrestin_C X +MAPK3 ERK1 P27361 human Securin 30939 Q9CQJ7 Pttg1 mouse S162 452603 LLHLGPPsPLKTPFL Securin X X +MAPK3 ERK1 P27361 human NFAT2 4772 O95644 NFATC1 human S172 465577 YRDPsCLsPASSLSS X +MAPK3 ERK1 P27361 human ARHGAP26 396113 Q5ZMW5 ARHGAP26 chicken S686 452134 PMFSAPSsPMPTSST X +MAPK3 ERK1 P27361 human GATA4 54254 P46152 Gata4 rat S105 449604 AYTPPPVsPRFSFPG GATA-N X +MAPK3 ERK1 P27361 human Tau iso8 4137 P10636-8 MAPT human T212 447934 tPGsRsRtPsLPtPP X +MAPK3 ERK1 P27361 human PDE4D iso6 5144 Q08499-6 PDE4D human S651 451090 YQSTIPQsPSPAPDD X +MAPK3 ERK1 P27361 human PML iso4 5371 P29590-4 PML human S36 451469 PSEGRQPsPsPsPTE X +MAPK3 ERK1 P27361 human eplin 51474 Q9UHB6 LIMA1 human S362 455424 PVHPkPLsPDsRAss X +MAPK3 ERK1 P27361 human LRP6 4040 O75581 LRP6 human T1572 3802448 EPVPPPPtPRsQyLs X +MAPK3 ERK1 P27361 human RHOA 387 P61586 RHOA human T100 53332704 ENIPEKWtPEVkHFC Ras X X +MAPK3 ERK1 P27361 human EEF2K 25435 P70531 Eef2k rat S358 447826 GTEEKCGsPRIRTLs X +MAPK3 ERK1 P27361 human Raptor 57521 Q8N122 RPTOR human S8 17538200 MESEMLQsPLLGLGE X X +MAPK3 ERK1 P27361 human CAD 790 P27708 CAD human T456 451248 KVYFLPItPHYVTQV X +MAPK3 ERK1 P27361 human SP1 6667 P08047 SP1 human T453 448226 SGPIIIRtPTVGPNG X +MAPK3 ERK1 P27361 human OSBP2 23762 Q969R2 OSBP2 human S763 31727226 CSKVMHssPssPsSD Oxysterol_BP X +MAPK3 ERK1 P27361 human HSF1 3297 Q00613 HSF1 human S326 455484 ssVDtLLsPTALIDs Vert_HS_TF X +MAPK3 ERK1 P27361 human FBXW7 55294 Q969H0 FBXW7 human T205 25585000 GLVPCSAtPTTFGDL X X +MAPK3 ERK1 P27361 human TAB1 10454 Q15750 TAB1 human S438 456224 tPTLTNQsPTLtLQS X +MAPK3 ERK1 P27361 human iNOS 4843 P35228 NOS2 human S745 763800 KSRQNLQsPTSSRAT FAD_binding_1 X X +MAPK3 ERK1 P27361 human NUP153 9972 P49790 NUP153 human S334 468336 RIPsIVssPLNsPLD Nup153 X +MAPK3 ERK1 P27361 human HDAC6 10013 Q9UBN7 HDAC6 human T1031 29604202 ASStDHQtPPtsPVQ X X +MAPK3 ERK1 P27361 human RARG 5916 P13631 RARG human S79 455544 EMVPSsPsPPPPPRV X +MAPK3 ERK1 P27361 human NUP214 8021 P35658 NUP214 human S1710 10296402 VSSSGFSsPAFGTTA X +MAPK3 ERK1 P27361 human Cortactin 2017 Q14247 CTTN human S418 447701 tEErLPssPVyEDAA X X +MAPK3 ERK1 P27361 human MSK1 9252 O75582 RPS6KA5 human T581 448217 PDNQPLKtPCFTLHY Pkinase X 9595 +MAPK3 ERK1 P27361 human DUSP6 1848 Q16828 DUSP6 human S300 5938000 CLAGISRsVTVTVAY DSPc X +MAPK3 ERK1 P27361 human NOXA1 10811 Q86UR1 NOXA1 human S282 12570900 VGKQAPLsPGLPAMG X +MAPK3 ERK1 P27361 human BANP 54971 Q8N9N5 BANP human T352 41301701 PSEPMMStPPPASEL X +MAPK3 ERK1 P27361 human Bcl-2 596 P10415 BCL2 human T56 448655 FSSQPGHtPHPAASR X 2875 +MAPK3 ERK1 P27361 human NUP153 9972 P49790 NUP153 human T413 10296400 TGYEkNMtPGQNREQ Nup153 X +MAPK3 ERK1 P27361 human Calnexin 821 P27824 CANX human S583 449100 EDEILNRsPRNRKPR X +MAPK3 ERK1 P27361 human hnRNP E2 5094 Q15366 PCBP2 human S189 482917 yRPkPsssPVIFAGG X X +MAPK3 ERK1 P27361 human GAB2 14389 Q9Z1S8 Gab2 mouse Y441 448384 SASSDDNyVPMNPGS X 3881; 3882 +MAPK3 ERK1 P27361 human GAB2 14389 Q9Z1S8 Gab2 mouse S469 4825114 QSVYIPMsPGPHHFD X X +MAPK3 ERK1 P27361 human mGluR5 108071 Q3UVX5 Grm5 mouse T1155 1872043501 LEELVALtPPsPFRD GluR_Homer-bdg X +MAPK3 ERK1 P27361 human Kv4.2 Q63881 Kcnd2 rat T607 457612 IPtPPVTtPEGDDRP X +MAPK3 ERK1 P27361 human KIBRA 23286 Q8IX03 WWC1 human S542 25673102 sPRSsLSsPSPPCsP X +MAPK3 ERK1 P27361 human ELK1 2002 P19419 ELK1 human S383 447872 IHFWSTLsPIAPRsP X X 9181; 9186 +MAPK3 ERK1 P27361 human Fos 2353 P01100 FOS human T325 448483 TELEPLCtPVVTCtP X +MAPK3 ERK1 P27361 human RAB3IP 29885 Q62739 Rab3ip rat S16 37039802 FHEVNLAsPTsPDLL X +MAPK3 ERK1 P27361 human GATA6 2627 Q92908 GATA6 human S266 2833503 VSARFPYsPsPPMAN GATA-N X +MAPK3 ERK1 P27361 human CDK5 12568 P49615 Cdk5 mouse Y15 448022 EkIGEGtyGtVFKAK Pkinase X 94254; 19051 +MAPK3 ERK1 P27361 human p53 7157 P04637 TP53 human S15 447490 PsVEPPLsQEtFsDL P53_TAD X 4030; 9235; 9284; 9286; 8695; 8514; 82530; 56979 +MAPK3 ERK1 P27361 human KLC1 16593 O88447 Klc1 mouse S459 477826 YKACKVDsPtVtttL X X +MAPK3 ERK1 P27361 human GLE1 2733 Q53GS7 GLE1 human S93 31084897 PKsPDAssAFsPAsP X +MAPK3 ERK1 P27361 human TOB1 10140 P50616 TOB1 human S164 455537 FGHSAAVsPTFMPRS X X +MAPK3 ERK1 P27361 human AML3 860 Q13950 RUNX2 human S28 3053615 PSTsRRFsPPSssLQ X +MAPK3 ERK1 P27361 human MARS 4141 P56192 MARS1 human S825 3193240 GGGQAktsPKPAVVE X X +MAPK3 ERK1 P27361 human GATA4 14463 Q08369 Gata4 mouse S105 449604 AYTPPPVsPRFSFPG GATA-N X +MAPK3 ERK1 P27361 human PML iso4 5371 P29590-4 PML human S40 451471 RQPsPsPsPTERAPA X +MAPK3 ERK1 P27361 human RSHL2 83861 Q86UC2 RSPH3 human T286 15414618 AFLDRPPtPLFIPAK Radial_spoke_3 X X +MAPK3 ERK1 P27361 human RAF1 5894 P04049 RAF1 human S296 455218 sPsALsssPNNLsPt X X 9431; 9423 +MAPK3 ERK1 P27361 human GAB2 9846 Q9UQC2 GAB2 human S623 454021 ALDFQPssPsPHRKP X X +MAPK3 ERK1 P27361 human RRas 6237 P10301 RRAS human S201 18015221 QEQELPPsPPsAPRK X X +MAPK3 ERK1 P27361 human GRASP65 56082 O35254 Gorasp1 rat S277 455582 EQLPGPGsPGHGTAD X X +MAPK3 ERK1 P27361 human SH2-B-beta 25970 Q9NRF2 SH2B1 human S96 457414 PPILAPLsPGAEIsP X +MAPK3 ERK1 P27361 human ERK1 5595 P27361 MAPK3 human Y204 447543 HtGFLtEyVAtRWyr Pkinase X 9106; 4370; 4374; 9101; 4375; 4376; 4377; 3510; 5726; 88569; 13214; 13148; 70235; 9488; 89967; 8544; 14196; 14227; 14095; 14474; 75165; 98168; 33370; 54240; 15892; 45899; 55088; 9524; 69217; 48735 +MAPK3 ERK1 P27361 human myocardin 214384 Q8VIM5 Myocd mouse S866 10791201 sPMHAQLsPPSVDSS X X +MAPK3 ERK1 P27361 human SPHK1 20698 Q8CI15 Sphk1 mouse S225 460682 VASKRPAstLVQKGP X +MAPK3 ERK1 P27361 human DAPK1 1612 P53355 DAPK1 human S734 454887 NsSRFPPsPLASKPT X +MAPK3 ERK1 P27361 human AML1 iso8 861 Q01196-8 RUNX1 human S293 454400 QYLGSIAsPSVHPAt X +MAPK3 ERK1 P27361 human GLE1 2733 Q53GS7 GLE1 human S92 50831365 VPKsPDAssAFsPAs X +MAPK3 ERK1 P27361 human Tau iso8 4137 P10636-8 MAPT human T205 447933 ssPGsPGtPGsRsRt X 25377; 43964; 53001; 49561; 20060; 33032; 30505; 20739; 98160 +MAPK3 ERK1 P27361 human WAVE2 10163 Q9Y6W5 WASF2 human T346 18715502 VGFGsPGtPPPPsPP X +MAPK3 ERK1 P27361 human TOP2A 7153 P11388 TOP2A human S1393 452242 GsVPLsssPPAtHFP X +MAPK3 ERK1 P27361 human XBP1 7494 P17861 XBP1 human S181 27523600 QQVQAQLsPLQNISP X +MAPK3 ERK1 P27361 human EPS8 13860 Q08509 Eps8 mouse T628 9467900 sAPsPPPtPAPVPVP X +MAPK3 ERK1 P27361 human EWS 2130 Q01844 EWSR1 human T79 7359501 QPPTGYTtPTAPQAY X +MAPK3 ERK1 P27361 human LIN28A 79727 Q9H9Z2 LIN28A human S200 7231811 EEEEEIHsPtLLPEA X X 20607 +MAPK3 ERK1 P27361 human Tau iso8 4137 P10636-8 MAPT human S422 449083 GsIDMVDsPQLAtLA X +MAPK3 ERK1 P27361 human HNF4 alpha 3172 P41235 HNF4A human S461 63076103 AtIVkPLsAIPQPtI X +MAPK3 ERK1 P27361 human NUP153 9972 P49790 NUP153 human S522 3191092 tsPsstGsPMFKFSs Nup153 X +MAPK3 ERK1 P27361 human p300 2033 Q09472 EP300 human S2039 31828207 GLGQVGIsPLKPGTV Creb_binding X +MAPK3 ERK1 P27361 human HNF4 alpha 3172 P41235 HNF4A human S151 20510207 yEDssLPsINALLQA X +MAPK3 ERK1 P27361 human Tau iso8 4137 P10636-8 MAPT human S235 449080 VVRtPPKsPssAKsR X 20473 +MAPK3 ERK1 P27361 human YTHDF2 51441 Q9Y5A9 YTHDF2 human T381 6223825 SQAGSGstPsEPHPV X X +MAPK3 ERK1 P27361 human GLE1 2733 Q53GS7 GLE1 human S88 12667856 QPSFVPKsPDAssAF X +MAPK3 ERK1 P27361 human SREBP-2 6721 Q12772 SREBF2 human S455 451008 SIDSEPGsPLLDDAK X X +MAPK3 ERK1 P27361 human NR0B2 23957 Q62227 Nr0b2 mouse S26 7596703 TILYALLsPSPRTRP X X +MAPK3 ERK1 P27361 human NPAS4 225872 Q8BGD7 Npas4 mouse S577 1871095700 LYEKLPPsPSsPGNG X +MAPK3 ERK1 P27361 human K8 3856 P05787 KRT8 human S432 448540 sAyGGLtsPGLsysL X X +MAPK3 ERK1 P27361 human PR 5241 P06401 PGR human S294 447987 APMAPGRsPLATTVM Prog_receptor X X 13736 +MAPK3 ERK1 P27361 human SMAD2 4087 Q15796 SMAD2 human T220 448793 QSNYIPEtPPPGYIS X X +MAPK3 ERK1 P27361 human p300 2033 Q09472 EP300 human S1038 10941006 STSATQssPAPGQsk X +MAPK3 ERK1 P27361 human TOP2A 7153 P11388 TOP2A human S1213 452237 QMAEVLPsPRGQRVI X +MAPK3 ERK1 P27361 human HNF4 alpha 3172 P41235 HNF4A human S265 63076101 LAEMsRVsIRILDEL Hormone_recep X +MAPK3 ERK1 P27361 human C/EBP-beta 1051 P17676 CEBPB human T235 447878 SsssPPGtPSPADAK X 3084 +MAPK3 ERK1 P27361 human Bcl-6 604 P41182 BCL6 human S343 471422 KsDCQPNsPTESCSS X +MAPK3 ERK1 P27361 human Kv4.2 Q63881 Kcnd2 rat T602 457611 TAIISIPtPPVTtPE X +MAPK3 ERK1 P27361 human vinexin iso2 10174 O60504-2 SORBS3 human S188 452554 DGPQLPTsPRLTAAA X +MAPK3 ERK1 P27361 human HER4 2066 Q15303 ERBB4 human T699 9430151 TELVEPLtPSGTAPN X +MAPK3 ERK1 P27361 human AML3 iso5 12393 Q08775-5 Runx2 mouse S319 10892802 SYLSQMTsPSIHSTt X +MAPK3 ERK1 P27361 human CDCA5 113130 Q96FF9 CDCA5 human S79 470691 AVQsPRRsPRIsFFL X +MAPK3 ERK1 P27361 human Caldesmon 800 Q05682 CALD1 human S789 448466 QsVDKVtsPtKV___ X +MAPK3 ERK1 P27361 human MAGE-A11 4110 P43364 MAGEA11 human S174 2028416 EsPsPPQsPQEESFs MAGE_N X X +MAPK3 ERK1 P27361 human IRX2 373975 Q9PU52 IRX2 chicken S326 452193 AALGGRAsPGPPTPA X +MAPK3 ERK1 P27361 human Myb 4602 P10242 MYB human S532 453087 KIkQEVEsPtDKSGN Cmyb_C X X +MAPK3 ERK1 P27361 human IRS1 3667 P35568 IRS1 human S616 447562 DDGyMPMsPGVAPVP X 3193; 2386; 3203 +MAPK3 ERK1 P27361 human STAT1 20846 P42225 Stat1 mouse S727 447753 tDNLLPMsPEEFDEM STAT1_TAZ2bind X X 9177; 8826; 62390 +MAPK3 ERK1 P27361 human ARRB2 25388 P29067 Arrb2 rat T178 36120700 KVQFAPEtPGPQPSA X +MAPK3 ERK1 P27361 human HIF2A 2034 Q99814 EPAS1 human S484 1876807202 SSCSTPNsPEDYYTS X +MAPK3 ERK1 P27361 human AR 367 P10275 AR human S516 452166 VSRVPYPsPTCVkSE X +MAPK3 ERK1 P27361 human AML3 860 Q13950 RUNX2 human S275 10892803 PsLNSAPsPFNPQGQ X +MAPK3 ERK1 P27361 human EXOC7 23265 Q9UPT5 EXOC7 human S250 483909 sSSGVPysPAIPNKR X +MAPK3 ERK1 P27361 human TH 21823 P24529 Th mouse S31 448544 KQAEAVtsPRFIGRR TOH_N X 3370; 13041 +Dapk3 DAPK3 O54784 mouse MRLC2V 17906 P51667 Myl2 mouse S15 2846506 kRIEGGssNVFsMFE X +Dapk3 DAPK3 O54784 mouse DAPK3 13144 O54784 Dapk3 mouse T265 454892 KDPKRRMtIAQSLEH Pkinase X +Dapk3 DAPK3 O54784 mouse MRLC2V 363925 P08733 Myl2 rat S15 2846506 KRLEGGssNVFSMFE X +RIPK3 RIPK3 Q9Y572 human MLKL 74568 Q9D2Y4 Mlkl mouse T349 8148779 TQNsIsRtAKSTKAE PK_Tyr_Ser-Thr X +RIPK3 RIPK3 Q9Y572 human DAXX 1616 Q9UER7 DAXX human S668 448623 KKICtLPsPPsPLAs X +RIPK3 RIPK3 Q9Y572 human AMPKA1 105787 Q5EG47 Prkaa1 mouse T183 448786 sDGEFLRtsCGsPNY Pkinase X 2535; 2531; 4188; 5256; 50081; 74281 +RIPK3 RIPK3 Q9Y572 human RIPK3 11035 Q9Y572 RIPK3 human S227 23003800 VELPtEPsLVYEAVC Pkinase X X 93654 +RIPK3 RIPK3 Q9Y572 human MLKL 197259 Q8NB16 MLKL human T357 5891858 FELRkTQtsMSLGTt PK_Tyr_Ser-Thr X X +RIPK3 RIPK3 Q9Y572 human DLD 1738 P09622 DLD human T135 18262251 STAVkALtGGIAHLF Pyr_redox_2 X +RIPK3 RIPK3 Q9Y572 human MLKL 197259 Q8NB16 MLKL human S358 22996309 ELRkTQtsMSLGTtR PK_Tyr_Ser-Thr X X 91689; 18640 +RIPK3 RIPK3 Q9Y572 human RIPK3 56532 Q9QZL0 Ripk3 mouse S232 23003800 AELVDKtsLIRETVC Pkinase X 57220; 91702 +RIPK3 RIPK3 Q9Y572 human AMPKA2 108079 Q8BRK8 Prkaa2 mouse T172 448026 sDGEFLRtsCGsPNY Pkinase X 2535; 2531; 5256; 50081; 74281 +RIPK3 RIPK3 Q9Y572 human MLKL 74568 Q9D2Y4 Mlkl mouse S345 22996309 ELSKTQNsIsRtAKS PK_Tyr_Ser-Thr X 37333; 17825 +RIPK3 RIPK3 Q9Y572 human RIPK3 56532 Q9QZL0 Ripk3 mouse T231 27928506 EAELVDKtsLIRETV Pkinase X 57220; 91702 +RIPK3 RIPK3 Q9Y572 human MLKL 74568 Q9D2Y4 Mlkl mouse S347 29611200 SKTQNsIsRtAKSTK PK_Tyr_Ser-Thr X +RIPK3 RIPK3 Q9Y572 human RIPK3 56532 Q9QZL0 Ripk3 mouse S165 27928503 KLADFGLsTFQGGSQ Pkinase X +RIPK3 RIPK3 Q9Y572 human RIPK3 11035 Q9Y572 RIPK3 human T182 1174709701 GSGEPGGtLGYLAPE Pkinase X +RIPK3 RIPK3 Q9Y572 human TIF1B 10155 Q13263 TRIM28 human S473 452391 sGVkRsRsGEGEVsG X +RIPK3 RIPK3 Q9Y572 human RIPK3 11035 Q9Y572 RIPK3 human T224 50788489 GREVELPtEPsLVYE Pkinase X +RIPK3 RIPK3 Q9Y572 human STAT1 20846 P42225 Stat1 mouse S727 447753 tDNLLPMsPEEFDEM STAT1_TAZ2bind X 9177; 8826; 62390 +MAP4K1 HPK1 Q92918 human BLNK 17060 Q9QUN3 Blnk mouse T152 23303201 AKARLAStLPAPNsL X 49183; 62144 +MAP4K1 HPK1 Q92918 human CARD11 84433 Q9BXL7 CARD11 human S558 4737145 MQPPRsRssIMsITA X +MAP4K1 HPK1 Q92918 human GADS 17444 O89100 Grap2 mouse T254 451895 TLMHRRHtDPVQLQA X +MAP4K1 HPK1 Q92918 human MLK3 4296 Q16584 MAP3K11 human S281 448262 WHKtTQMsAAGTYAW PK_Tyr_Ser-Thr X +MAP4K1 HPK1 Q92918 human CARD11 84433 Q9BXL7 CARD11 human S556 4737139 tKMQPPRsRssIMsI X +MAP4K1 HPK1 Q92918 human PSMD2 5708 Q13200 PSMD2 human S361 487471 ENNrFGGsGsQVDsA X +MAP4K1 HPK1 Q92918 human SLP76 16822 Q60787 Lcp2 mouse S376 476784 IGFQQSAsLPPYFSQ X 14745; 76384; 76143; 63654; 47876; 61762; 94697; 15642; 10190 +MAP4K1 HPK1 Q92918 human HPK1 11184 Q92918 MAP4K1 human T165 455473 ISAQIGAtLARRLsF Pkinase X +MAP4K1 HPK1 Q92918 human SLP76 3937 Q13094 LCP2 human S376 476784 SSFPQsAsLPPYFSQ X X 14745; 90247; 40887; 92711; 16318; 76384; 76143; 63654; 83768; 47876; 61762; 94697; 15642; 10190; 72511 +Aurkc AurC O88445 mouse H3 360198 P68433 H3c1 mouse S10 455676 tkQTARkstGGkAPr Histone X 9701; 9711; 9606; 3465; 3642; 3377; 3475; 3458; 5764; 47398; 8481; 8552; 53348; 29237; 66065; 43185; 64522; 52725 +Aurkc AurC O88445 mouse AurC 20871 O88445 Aurkc mouse T171 455456 TPSLRRKtMCGtLDY Pkinase X 2914; 13464; 8525 +EPHB2 EphB2 P29323 human TAGAP 117289 Q8N103 TAGAP human Y310 6154570 TLQNDSAyDSNDPDV X +EPHB2 EphB2 P29323 human NCAM-L1 3897 P32004 L1CAM human Y1229 10272401 DGSFIGQySGKKEkE Bravo_FIGEY X +EPHB2 EphB2 P29323 human syndecan-2 25615 P34900 Sdc2 rat Y191 448376 RKPssAAyQKAPTKE Syndecan X X +EPHB2 EphB2 P29323 human syndecan-2 25615 P34900 Sdc2 rat Y179 448375 RKKDEGSyDLGERKP Syndecan X X +EPHB2 EphB2 P29323 human RRas 6237 P10301 RRAS human Y66 448122 DPTIEDSyTKICSVD Ras X +EPHB2 EphB2 P29323 human NCAM-L1 16728 P11627 L1cam mouse Y1232 10272401 DGsFIGQySGKKEKE Bravo_FIGEY X +EPHB2 EphB2 P29323 human Src 6714 P12931 SRC human Y419 448234 RLIEDNEytARQGAk PK_Tyr_Ser-Thr X 2101; 6943; 59548; 70926; 78740; 94361; 17320 +PAK2 PAK2 Q29502 rabbit PAK2 100009535 Q29502 PAK2 rabbit S192 448296 PRPDHTKsIYTRsVI X +PAK2 PAK2 Q29502 rabbit PAK2 100009535 Q29502 PAK2 rabbit S20 448298 APPVRMssTIFSTGG X +PAK2 PAK2 Q29502 rabbit PAK2 100009535 Q29502 PAK2 rabbit T402 448300 PEQSKRStMVGTPYW Pkinase X +PAK2 PAK2 Q29502 rabbit PAK2 100009535 Q29502 PAK2 rabbit S55 448299 KPRNKIIsIFSGTEK X +PAK2 PAK2 Q29502 rabbit PAK2 100009535 Q29502 PAK2 rabbit S19 449843 PAPPVRMssTIFSTG X +PAK2 PAK2 Q29502 rabbit PAK2 100009535 Q29502 PAK2 rabbit S141 448295 TVKQKYLsFTPPEKD X +PAK2 PAK2 Q29502 rabbit PAK2 100009535 Q29502 PAK2 rabbit S165 449844 NTKVSETsAVVTEED X +PAK2 PAK2 Q29502 rabbit PAK2 100009535 Q29502 PAK2 rabbit S197 448297 TKsIYTRsVIDPIPA X +Stk38l NDR2 Q7TSE6 mouse YAP1 22601 P46938 Yap1 mouse S382 3190672 TyHSRDEstDsGLSM X 13619 +Stk38l NDR2 Q7TSE6 mouse YAP1 22601 P46938 Yap1 mouse S112 448847 PQHVRAHssPAsLQL X 4911; 13008; 92367; 57706 +CAMKK1 CAMKK1 Q8N5S9 human AMPKA1 5562 Q13131 PRKAA1 human T183 448786 sDGEFLRtsCGsPNy Pkinase X 2535; 2531; 4188; 5256; 50081; 74281 +CAMKK1 CAMKK1 Q8N5S9 human CAMK1D 57118 Q8IU85 CAMK1D human T180 450469 GkGDVMstACGTPGY Pkinase X +CAMKK1 CAMKK1 Q8N5S9 human CAMK4 814 Q16566 CAMK4 human S12 2135600 TVPSCSAssCSSVTA X +CAMKK1 CAMKK1 Q8N5S9 human CAMK4 814 Q16566 CAMK4 human T200 448164 EHQVLMktVCGtPGY Pkinase X +CAMKK1 CAMKK1 Q8N5S9 human BRSK1 iso2 84446 Q8TDC3-2 BRSK1 human T205 456027 VGDSLLEtSCGsPHY Pkinase X +CAMKK1 CAMKK1 Q8N5S9 human PACSIN1 29704 Q9Z0W5 Pacsin1 rat T355 20503414 DRGQAYAtEWsDDEs X X +CAMKK1 CAMKK1 Q8N5S9 human CAMK4 814 Q16566 CAMK4 human S13 2135601 VPSCSAssCSSVTAS X +CAMKK1 CAMKK1 Q8N5S9 human CAMK1A 8536 Q14012 CAMK1 human T177 448527 DPGsVLstACGTPGY Pkinase X +Pim3 Pim3 P58750 mouse BAD 12015 Q61337 Bad mouse S170 447864 KGLPRPKsAGtATQM Bcl-2_BAD X +Pim3 Pim3 P58750 mouse BAD 12015 Q61337 Bad mouse S112 447860 ETRsRHssyPAGtEE Bcl-2_BAD X 9291; 5284; 9296; 5193; 11865; 94223 +Pim3 Pim3 P58750 mouse NOTCH3 18131 Q61982 Notch3 mouse S1673 11179168 ARRKREHsTLWFPEG X +Pim3 Pim3 P58750 mouse BAD 12015 Q61337 Bad mouse T173 1904506 PRPKsAGtATQMRQS Bcl-2_BAD X +Pim3 Pim3 P58750 mouse BAD 12015 Q61337 Bad mouse S96 1904505 QGRAAtNsHHGGAGA Bcl-2_BAD X +Pim3 Pim3 P58750 mouse BAD 12015 Q61337 Bad mouse T94 1904504 HQQGRAAtNsHHGGA Bcl-2_BAD X +Pim3 Pim3 P58750 mouse BAD 12015 Q61337 Bad mouse S155 447863 GRELRRMsDEFEGsF Bcl-2_BAD X 9297 +Pim3 Pim3 P58750 mouse BAD 12015 Q61337 Bad mouse S136 447862 PFRGRsRsAPPNLWA Bcl-2_BAD X 9295; 5286; 4366 +Map2k1 MEK1 Q01986 rat ERK1 50689 P21708 Mapk3 rat Y205 447543 HTGFLtEyVAtRWYR Pkinase X X 9106; 4370; 4374; 9101; 4375; 4376; 4377; 3510; 5726; 88569; 13214; 13148; 70235; 9488; 89967; 8544; 14196; 14227; 14095; 14474; 75165; 98168; 33370; 54240; 15892; 45899; 55088; 9524; 69217; 48735 +Map2k1 MEK1 Q01986 rat MEK1 170851 Q01986 Map2k1 rat S218 448514 VsGQLIDsMANsFVG Pkinase X X 9121; 3958; 9154; 86128 +Map2k1 MEK1 Q01986 rat ERK2 26413 P63085 Mapk1 mouse Y185 447594 HtGFLtEyVAtRWYR Pkinase X 9106; 4370; 4374; 9101; 4375; 4376; 4377; 3510; 5726; 88569; 13214; 13148; 70235; 9488; 89967; 8544; 14196; 14227; 14095; 14474; 75165; 98168; 33370; 54240; 15892; 45899; 55088; 9524; 69217; 48735 +Map2k1 MEK1 Q01986 rat ERK1 26417 Q63844 Mapk3 mouse T203 447542 HDHtGFLtEyVAtRW Pkinase X 9106; 4370; 4374; 9101; 4375; 4376; 4377; 3510; 5726; 88569; 13214; 13148; 70235; 9488; 89967; 8544; 14196; 14227; 14095; 14474; 75165; 98168; 33370; 54240; 15892; 45899; 55088; 9524; 69217; 48735 +Map2k1 MEK1 Q01986 rat ERK2 26413 P63085 Mapk1 mouse T183 447593 HDHtGFLtEyVAtRW Pkinase X 9106; 4370; 4374; 9101; 4375; 4376; 4377; 3510; 5726; 88569; 13214; 13148; 70235; 9488; 89967; 8544; 14196; 14227; 14095; 14474; 75165; 98168; 33370; 54240; 15892; 45899; 55088; 9524; 69217; 48735 +Map2k1 MEK1 Q01986 rat ERK2 116590 P63086 Mapk1 rat T183 447593 HDHtGFLtEyVAtRW Pkinase X X 9106; 4370; 4374; 9101; 4375; 4376; 4377; 3510; 5726; 88569; 13214; 13148; 70235; 9488; 89967; 8544; 14196; 14227; 14095; 14474; 75165; 98168; 33370; 54240; 15892; 45899; 55088; 9524; 69217; 48735 +Map2k1 MEK1 Q01986 rat ERK1 50689 P21708 Mapk3 rat T203 447542 HDHTGFLtEyVAtRW Pkinase X X 9106; 4370; 4374; 9101; 4375; 4376; 4377; 3510; 5726; 88569; 13214; 13148; 70235; 9488; 89967; 8544; 14196; 14227; 14095; 14474; 75165; 98168; 33370; 54240; 15892; 45899; 55088; 9524; 69217; 48735 +Map2k1 MEK1 Q01986 rat ERK1 26417 Q63844 Mapk3 mouse Y205 447543 HtGFLtEyVAtRWyR Pkinase X 9106; 4370; 4374; 9101; 4375; 4376; 4377; 3510; 5726; 88569; 13214; 13148; 70235; 9488; 89967; 8544; 14196; 14227; 14095; 14474; 75165; 98168; 33370; 54240; 15892; 45899; 55088; 9524; 69217; 48735 +Map2k1 MEK1 Q01986 rat Bcl-2 24224 P49950 Bcl2 rat S70 448395 RDTAARTsPLRPLVA X +Map2k1 MEK1 Q01986 rat MEK1 170851 Q01986 Map2k1 rat S222 448513 LIDsMANsFVGTRSY Pkinase X X 2338; 9121; 3958; 9154; 16211; 86128; 16780; 75262 +Map2k1 MEK1 Q01986 rat ERK2 116590 P63086 Mapk1 rat Y185 447594 HtGFLtEyVAtRWYR Pkinase X X 9106; 4370; 4374; 9101; 4375; 4376; 4377; 3510; 5726; 88569; 13214; 13148; 70235; 9488; 89967; 8544; 14196; 14227; 14095; 14474; 75165; 98168; 33370; 54240; 15892; 45899; 55088; 9524; 69217; 48735 +Map2k1 MEK1 Q01986 rat TH 25085 P04177 Th rat S31 448544 KQAEAVtsPRFIGRR TOH_N X 3370; 13041 +Jak2 JAK2 Q62120 mouse JAK2 16452 Q62120 Jak2 mouse Y972 470145 EyLGTKRyIHRDLAT PK_Tyr_Ser-Thr X X +Jak2 JAK2 Q62120 mouse JAK2 16452 Q62120 Jak2 mouse Y1008 448408 LPQDKEyyKVKEPGE PK_Tyr_Ser-Thr X 3771; 3776; 8082; 66245; 32901 +Jak2 JAK2 Q62120 mouse JAK2 16452 Q62120 Jak2 mouse Y570 451494 VRREVGDyGQLHKTE PK_Tyr_Ser-Thr X X +Jak2 JAK2 Q62120 mouse JAK3 16453 Q62137 Jak3 mouse Y820 1876350204 FEERHLKyISLLGKG PK_Tyr_Ser-Thr X +Jak2 JAK2 Q62120 mouse SH2-B-beta 89817 Q62985 Sh2b1 rat Y439 448753 DRLSQGAyGGLSDRP X X +Jak2 JAK2 Q62120 mouse ASS1 11898 P16460 Ass1 mouse Y87 4273690 SALYEDRyLLGTsLA Arginosuc_synth X X +Jak2 JAK2 Q62120 mouse JAK2 16452 Q62120 Jak2 mouse Y868 470141 GSVEMCRyDPLQDNT PK_Tyr_Ser-Thr X X +Jak2 JAK2 Q62120 mouse JAK2 16452 Q62120 Jak2 mouse Y206 470071 AVyNSVSyKTFLPKC FERM_F2 X +Jak2 JAK2 Q62120 mouse JAK2 16452 Q62120 Jak2 mouse Y119 470132 ILYRIRFyFPHWYCS FERM_F1 X +Jak2 JAK2 Q62120 mouse STAT3 20848 P42227 Stat3 mouse Y705 448192 DPGsAAPyLktkFIC X 4093; 9145; 4324; 9131; 9138; 4323; 4074; 4113; 48313; 20977; 25023; 8119; 52075; 52527; 73533; 61958; 73452; 16185; 74309 +Jak2 JAK2 Q62120 mouse JAK2 16452 Q62120 Jak2 mouse Y931 462253 NLRLIMEyLPyGSLR PK_Tyr_Ser-Thr X +Jak2 JAK2 Q62120 mouse JAK2 16452 Q62120 Jak2 mouse Y940 470144 PyGSLRDyLQKHKER PK_Tyr_Ser-Thr X +Jak2 JAK2 Q62120 mouse STAT5B 25126 P52632 Stat5b rat Y699 448198 TAKAADGyVKPQIKQ X 9365; 9356; 9359; 9351; 4322; 9314; 3939; 40284; 5387; 14603; 66740; 51879; 72712 +Jak2 JAK2 Q62120 mouse ATOH1 11921 P48985 Atoh1 mouse Y78 386186604 CTARAAQyLLHSPEL X +Jak2 JAK2 Q62120 mouse SHP-2 19247 P35235 Ptpn11 mouse Y327 451496 NSKPKKSyIATQGCL Y_phosphatase X +Jak2 JAK2 Q62120 mouse STAT5A 20850 P42230 Stat5a mouse Y694 447767 LAKAVDGyVkPQIKQ X 9365; 9356; 9359; 9351; 4322; 9314; 3939; 40284; 5387; 14603; 66740; 51879; 72712 +Jak2 JAK2 Q62120 mouse JAK2 16452 Q62120 Jak2 mouse Y637 470140 KFGsLDTyLKKNKNS PK_Tyr_Ser-Thr X X +Jak2 JAK2 Q62120 mouse JAK2 16452 Q62120 Jak2 mouse Y317 7603503 TEQDVQLyCDFPDII Jak1_Phl X +Jak2 JAK2 Q62120 mouse SH2-B-beta 89817 Q62985 Sh2b1 rat Y494 448754 VHPLSTPyPPLDTPE X X +Jak2 JAK2 Q62120 mouse JAK2 16452 Q62120 Jak2 mouse Y966 462255 QICKGMEyLGTKRyI PK_Tyr_Ser-Thr X X +Jak2 JAK2 Q62120 mouse p27Kip1 12576 P46414 Cdkn1b mouse Y88 456818 RGsLPEFyYRPPRPP X X +Jak2 JAK2 Q62120 mouse SHP-2 19247 P35235 Ptpn11 mouse Y304 451495 PNEPVSDyINANIIM Y_phosphatase X +Jak2 JAK2 Q62120 mouse JAK2 16452 Q62120 Jak2 mouse Y813 451492 NSLFTPDyELLTEND X +Jak2 JAK2 Q62120 mouse JAK2 16452 Q62120 Jak2 mouse Y1007 448407 VLPQDKEyyKVKEPG PK_Tyr_Ser-Thr X 3771; 3776; 4406; 66245; 32901 +Jak2 JAK2 Q62120 mouse GSK3B 56637 Q9WV60 Gsk3b mouse Y216 448569 RGEPNVsyICsRYYR Pkinase X X +Jak2 JAK2 Q62120 mouse JAK2 16452 Q62120 Jak2 mouse Y201 470070 DQTPLAVyNSVSyKT FERM_F2 X +Jak2 JAK2 Q62120 mouse JAK2 16452 Q62120 Jak2 mouse Y918 470142 VkyKGVCySAGRRNL PK_Tyr_Ser-Thr X +Jak2 JAK2 Q62120 mouse JAK2 16452 Q62120 Jak2 mouse Y934 470143 LIMEyLPyGSLRDyL PK_Tyr_Ser-Thr X +Jak2 JAK2 Q62120 mouse JAK3 16453 Q62137 Jak3 mouse Y976 447636 LLPLGKDyyVVREPG PK_Tyr_Ser-Thr X 5031; 32901 +Jak2 JAK2 Q62120 mouse JAK2 16452 Q62120 Jak2 mouse Y221 451493 VRAKIQDyHILTRKR FERM_F2 X X 3774 +Jak2 JAK2 Q62120 mouse JAK2 16452 Q62120 Jak2 mouse Y913 3345200 QHDNIVkyKGVCySA PK_Tyr_Ser-Thr X +BMP2K BIKE Q9NSY1 human AP2M1 1173 Q96CW1 AP2M1 human T156 448782 SQItsQVtGQIGWRR X 3843; 7399 +BMP2K BIKE Q9NSY1 human ENTH 9685 Q14677 CLINT1 human T294 3196412 LGAAAHytGDkAsPD X X +Camk4 CAMK4 P08414 mouse DRP1 74006 Q8K1M6 Dnm1l mouse S622 454690 PIPIMPAsPQKGHAV X X 3455; 4494; 63940 +Camk4 CAMK4 P08414 mouse CREB iso1 81646 P15337-1 Creb1 rat S133 448228 EILsRRPsYRkILND pKID X X 9187; 9196; 9198; 4095; 14228; 14001; 39561; 80120; 44864; 54960; 95995 +Camk4 CAMK4 P08414 mouse gp130 16195 Q00560 Il6st mouse S780 448180 QVFSRsEstQPLLDs X X +ALPK3 AlphaK1 Q96L96 human TIFA 92610 Q96CG3 TIFA human T177 4743087 SSQSSSPtEMDENES X +ALPK3 AlphaK1 Q96L96 human TIFA 92610 Q96CG3 TIFA human T9 50409900 tSFEDADtEEtVTCL X +ALPK3 AlphaK1 Q96L96 human TIFA 92610 Q96CG3 TIFA human T19 1881522404 tVTCLQMtVYHPGQL X +ALPK3 AlphaK1 Q96L96 human TIFA 92610 Q96CG3 TIFA human T2 1881522400 ______MtSFEDADt X +ALPK3 AlphaK1 Q96L96 human TIFA 92610 Q96CG3 TIFA human T12 1881522402 EDADtEEtVTCLQMt X +Fes Fes P16879 mouse HS1 15163 P49710 Hcls1 mouse Y405 451636 DEDAEGDyEDVLEPE X 8714; 13708; 11880 +Fes Fes P16879 mouse PECAM-1 18613 Q08481 Pecam1 mouse Y702 448760 TRATETVysEIRKVD X +Fes Fes P16879 mouse PECAM-1 18613 Q08481 Pecam1 mouse Y717 465455 PNLMENRysRTEGSL X +Fes Fes P16879 mouse HS1 15163 P49710 Hcls1 mouse Y388 451635 EPEtEPDyEDVGELD X +CDK11A CDK11A Q9UQ88 human SPDEF 25803 O95238 SPDEF human S238 54165904 SEESWTDsEVDssCS X X +CDK11A CDK11A Q9UQ88 human SPDEF 25803 O95238 SPDEF human S243 54165902 TDsEVDssCSGQPIH X X +CDK11A CDK11A Q9UQ88 human SPDEF 25803 O95238 SPDEF human S242 54165903 WTDsEVDssCSGQPI X X +Csnk2b CK2B P67874 rat CACNA1A 12286 P97445 Cacna1a mouse S2363 4713052 AHDAYsEsEDDWC__ X +Csnk2b CK2B P67874 rat CACNA1A 12286 P97445 Cacna1a mouse S2361 4713048 RGAHDAYsEsEDDWC X +CSNK1D CK1D P48730 human DVL2 13543 Q60838 Dvl2 mouse S594 22682201 EGSRssGstRsDGGA Dsh_C X +CSNK1D CK1D P48730 human HIF2A 2034 Q99814 EPAS1 human T528 59087902 FNELDLEtLAPYIPM HIF-1 X +CSNK1D CK1D P48730 human DVL2 13543 Q60838 Dvl2 mouse T595 27623903 GSRssGstRsDGGAG Dsh_C X +CSNK1D CK1D P48730 human TDP-43 23435 Q13148 TARDBP human S393 6855908 GsAsNAGsGsGFNGG X +CSNK1D CK1D P48730 human LZTS2 84445 Q9BRK4 LZTS2 human S224 1871717502 LSDsGRNsLSSLPTY X +CSNK1D CK1D P48730 human hnRNP P2 2521 P35637 FUS human S163 1878186700 GQQNQYNssSGGGGG X +CSNK1D CK1D P48730 human SNCA 6622 P37840 SNCA human T64 1876998407 EktkEQVtNVGGAVV Synuclein X +CSNK1D CK1D P48730 human YAP1 10413 P46937 YAP1 human S400 9764918 SRDEstDsGLsMsSy X X +CSNK1D CK1D P48730 human MDM2 4193 Q00987 MDM2 human T351 17342607 kAkLENstQAEEGFD X +CSNK1D CK1D P48730 human ATOH1 11921 P48985 Atoh1 mouse S347 57761905 PHSHYsDsDEAS___ X +CSNK1D CK1D P48730 human MDM2 4193 Q00987 MDM2 human S386 11956709 DDKITQAsQsQESED X +CSNK1D CK1D P48730 human BACE 23621 P56817 BACE1 human S498 450178 DDFADDIsLLk____ X +CSNK1D CK1D P48730 human ATOH1 11921 P48985 Atoh1 mouse S339 34425603 HRsDGEFsPHSHYsD X +CSNK1D CK1D P48730 human SMARCA4 6597 P51532 SMARCA4 human S35 1261736701 LGPsPGPsPGSAHSM X X +CSNK1D CK1D P48730 human APC 324 P25054 APC human S1507 452097 FsCsssLsALsLDEP APC_r X +CSNK1D CK1D P48730 human MDM2 4193 Q00987 MDM2 human S260 454923 sLDsEDYsLsEEGQE X +CSNK1D CK1D P48730 human MDM2 4193 Q00987 MDM2 human S350 17342609 EkAkLENstQAEEGF X +CSNK1D CK1D P48730 human p53 7157 P04637 TP53 human S9 447538 EEPQsDPsVEPPLsQ P53_TAD X 9288 +CSNK1D CK1D P48730 human SNCA 20617 O55042 Snca mouse T64 1876998407 EKtKEQVtNVGGAVV Synuclein X +CSNK1D CK1D P48730 human ATOH1 11921 P48985 Atoh1 mouse S311 57761906 AQKDLsPsLPGGILQ X +CSNK1D CK1D P48730 human LZTS2 84445 Q9BRK4 LZTS2 human S273 25299402 TGPsHsDsGRsssSK X +CSNK1D CK1D P48730 human p53 7157 P04637 TP53 human T18 447541 EPPLsQEtFsDLWkL P53_TAD X 2529 +CSNK1D CK1D P48730 human Tau iso8 4137 P10636-8 MAPT human S396 449081 GAEIVyKsPVVsGDt X X 9632 +CSNK1D CK1D P48730 human DVL2 13543 Q60838 Dvl2 mouse S592 27623905 HSEGSRssGstRsDG Dsh_C X +CSNK1D CK1D P48730 human Tau iso8 4137 P10636-8 MAPT human S404 449082 PVVsGDtsPRHLsNV X X 35834; 20194; 98523; 91600; 49562 +CSNK1D CK1D P48730 human hnRNP P2 2521 P35637 FUS human S183 1878186706 NYGQDQssMSSGGGS X +CSNK1D CK1D P48730 human HIF2A 2034 Q99814 EPAS1 human S383 59087903 SSGKGAVsEkSNFLF X +CSNK1D CK1D P48730 human MDM2 17246 P23804 Mdm2 mouse S238 454919 GDCLDQDsVsDQFsV X +CSNK1D CK1D P48730 human CTNNB1 1499 P35222 CTNNB1 human S45 447488 GATtTAPsLsGkGNP X 9565; 9564; 24710; 70034; 19807; 96727; 77605 +CSNK1D CK1D P48730 human p53 22059 P02340 Tp53 mouse S12 447538 EEsQsDIsLELPLsQ P53_TAD X X +CSNK1D CK1D P48730 human MDM2 4193 Q00987 MDM2 human S172 17342602 IsEtEENsDELsGER X +CSNK1D CK1D P48730 human LRP6 4040 O75581 LRP6 human S1490 456289 AILNPPPsPAtERsH X 2568 +CSNK1D CK1D P48730 human DCK 1633 P27707 DCK human S11 460585 PPKRsCPsFsAssEG X +CSNK1D CK1D P48730 human TDP-43 23435 Q13148 TARDBP human S317 54023801 GMNFGAFsINPAMMA X +CSNK1D CK1D P48730 human TDP-43 23435 Q13148 TARDBP human S409 3084616 GssMDskssGWGM__ X X +CSNK1D CK1D P48730 human MDM2 17246 P23804 Mdm2 mouse S244 454925 DsVsDQFsVEFEVES X +CSNK1D CK1D P48730 human hnRNP P2 2521 P35637 FUS human S182 1878186704 GNYGQDQssMSSGGG X X +CSNK1D CK1D P48730 human UHRF1 29128 Q96T88 UHRF1 human S95 3210060 sELsDtDsGCCLGQS X X +CSNK1D CK1D P48730 human ATOH1 11921 P48985 Atoh1 mouse S309 57761909 MMAQKDLsPsLPGGI X +CSNK1D CK1D P48730 human MBP 618684 P02687 MBP cow S109 451768 QGKGrGLsLSRFsWG Myelin_MBP X +CSNK1D CK1D P48730 human SMARCA4 6597 P51532 SMARCA4 human S31 1261736700 PGAMLGPsPGPsPGS X X +CSNK1D CK1D P48730 human LZTS2 84445 Q9BRK4 LZTS2 human S220 1871717501 PSGTLSDsGRNsLSS X +CSNK1D CK1D P48730 human hnRNP P2 2521 P35637 FUS human S221 12217071 GGrGrGGsGGGGGGG X +CSNK1D CK1D P48730 human MDM2 4193 Q00987 MDM2 human T365 17342610 DVPDCkktIVNDSRE X +CSNK1D CK1D P48730 human YAP1 10413 P46937 YAP1 human S403 3190675 EstDsGLsMsSySVP X X +CSNK1D CK1D P48730 human Cas-L 4739 Q14511 NEDD9 human T804 348338201 AALHYPStTALQEMV CAS_C X +CSNK1D CK1D P48730 human APC 324 P25054 APC human S1510 999606 sssLsALsLDEPFIQ X +CSNK1D CK1D P48730 human PRKD2 25865 Q9BZL6 PRKD2 human S244 1028300 sssSssAssyTGRPI X X +CSNK1D CK1D P48730 human MDM2 4193 Q00987 MDM2 human S176 17342604 EENsDELsGERQRkR X +CSNK1D CK1D P48730 human SRC-3 8202 Q9Y6Q9 NCOA3 human S601 7596700 SDKESKEsSVEGAEN X X +CSNK1D CK1D P48730 human FOXO1A 84482 G3V7R4 Foxo1 rat S316 449112 PRTSsNAsTIsGRLs X X +CSNK1D CK1D P48730 human MDM2 4193 Q00987 MDM2 human S229 17342601 PDLDAGVsEHSGDWL X +CSNK1D CK1D P48730 human APC 324 P25054 APC human S1504 999604 PDGFsCsssLsALsL APC_r X +CSNK1D CK1D P48730 human MDM2 4193 Q00987 MDM2 human S269 455458 sEEGQELsDEDDEVy X +CSNK1D CK1D P48730 human p53 22059 P02340 Tp53 mouse S7 448716 _MTAMEEsQsDIsLE X X +CSNK1D CK1D P48730 human p53 22059 P02340 Tp53 mouse S9 447537 TAMEEsQsDIsLELP P53_TAD X X 9285 +CSNK1D CK1D P48730 human TOP2B iso2 7155 Q02880-2 TOP2B human S1130 23154509 HDDSSSDsGTPsGPD DNA_topoisoIV X +CSNK1D CK1D P48730 human TDP-43 23435 Q13148 TARDBP human S305 6855916 GLGNNQGsNMGGGMN X +CSNK1D CK1D P48730 human Wee1 7465 P30291 WEE1 human S212 25316778 SVkLRGssLFMDtEK X +CSNK1D CK1D P48730 human hnRNP P2 2521 P35637 FUS human S273 23113764 GGPrDQGsRHDsEQD X +CSNK1D CK1D P48730 human HIF1A 3091 Q16665 HIF1A human S247 15434302 KTFLSRHsLDMkFSY X X +CSNK1D CK1D P48730 human ZNF322A 79692 Q6U7Q0 ZNF322 human S396 114810401 ELsPPHAsEAsQMS_ X +CSNK1D CK1D P48730 human PER2 8864 O15055 PER2 human S662 449331 ALPGKAEsVAsLTsQ X +CSNK1D CK1D P48730 human ATOH1 11921 P48985 Atoh1 mouse S325 57761904 QPVQEDNsKTsPRsH X +CSNK1D CK1D P48730 human DCK 1633 P27707 DCK human T72 4645914 QDEFEELtMsQkNGG dNK X +CSNK1D CK1D P48730 human Tau iso8 4137 P10636-8 MAPT human S202 447928 sGyssPGsPGtPGsR X X 39357; 30505 +CSNK1D CK1D P48730 human hnRNP P2 2521 P35637 FUS human S346 14160213 VsFDDPPsAkAAIDW RRM_1 X +CSNK1D CK1D P48730 human DVL2 1856 O14641 DVL2 human S143 7320089 FHPNVSssHENLEPE Dishevelled X X +CSNK1D CK1D P48730 human TDP-43 23435 Q13148 TARDBP human S410 3084601 ssMDskssGWGM___ X X +CSNK1D CK1D P48730 human ATOH1 11921 P48985 Atoh1 mouse S328 34425604 QEDNsKTsPRsHRsD X +CSNK1D CK1D P48730 human PPP5C 5536 P53041 PPP5C human T362 344893200 LFSEDGVtLDDIRKI Metallophos X X +CSNK1D CK1D P48730 human MDM2 4193 Q00987 MDM2 human S220 17342605 SESTGtPsNPDLDAG X +CSNK1D CK1D P48730 human ATOH1 11921 P48985 Atoh1 mouse S345 57761907 FsPHSHYsDsDEAS_ X +CSNK1D CK1D P48730 human DVL2 13543 Q60838 Dvl2 mouse S597 22682200 RssGstRsDGGAGRT Dsh_C X +CSNK1D CK1D P48730 human MDM2 4193 Q00987 MDM2 human S262 454944 DsEDYsLsEEGQELs X +CSNK1D CK1D P48730 human CDH1 999 P12830 CDH1 human S844 478354 GsGsEAAsLSsLNsS CADH_Y-type_LIR X +CSNK1D CK1D P48730 human DCK 1633 P27707 DCK human S15 460586 sCPsFsAssEGtRIK X +CSNK1D CK1D P48730 human TDP-43 23435 Q13148 TARDBP human S333 54023800 AQAALQSsWGMMGML X +CSNK1D CK1D P48730 human TDP-43 23435 Q13148 TARDBP human S395 6855914 AsNAGsGsGFNGGFG X +CSNK1D CK1D P48730 human MDM2 4193 Q00987 MDM2 human S342 17342606 GkDkGEIsEkAkLEN X +CSNK1D CK1D P48730 human hnRNP P2 2521 P35637 FUS human S462 18801758 PGGGPGGsHMGGNyG X +CSNK1D CK1D P48730 human MDM2 4193 Q00987 MDM2 human S166 448130 SsRRRAIsEtEENsD X 3521 +CSNK1D CK1D P48730 human DVL2 1856 O14641 DVL2 human T224 25538000 MSRFssStEQSsASR Dishevelled X X +CSNK1D CK1D P48730 human TDP-43 23435 Q13148 TARDBP human S403 3084617 GFNGGFGssMDskss X X +CSNK1D CK1D P48730 human hnRNP P2 2521 P35637 FUS human S277 1232880 DQGsRHDsEQDNSDN X +CSNK1D CK1D P48730 human MDM2 17246 P23804 Mdm2 mouse S240 454921 CLDQDsVsDQFsVEF X +CSNK1D CK1D P48730 human MDM2 4193 Q00987 MDM2 human T419 448132 KEFEREEtQDKEEsV X +CSNK1D CK1D P48730 human PER2 8864 O15055 PER2 human S668 20688400 EsVAsLTsQCsYSST X +CSNK1D CK1D P48730 human DCK 1633 P27707 DCK human S74 456305 EFEELtMsQkNGGNV dNK X 40371 +CSNK1D CK1D P48730 human TDP-43 23435 Q13148 TARDBP human S404 3084635 FNGGFGssMDskssG X X +CSNK1D CK1D P48730 human hnRNP P2 2521 P35637 FUS human T338 1878186708 GkLkGEAtVsFDDPP X +CSNK1D CK1D P48730 human PSEN2 5664 P49810 PSEN2 human S330 448567 MEEDsYDsFGEPsYP Presenilin; Presenilin X +CSNK1D CK1D P48730 human p53 7157 P04637 TP53 human S20 447529 PLsQEtFsDLWkLLP P53_TAD X 9287 +CSNK1D CK1D P48730 human MDM2 4193 Q00987 MDM2 human S373 17342608 IVNDSREsCVEENDD X +CSNK1D CK1D P48730 human CTNNB1 12387 Q02248 Ctnnb1 mouse S47 34606438 TtTAPsLsGkGNPEE X +CSNK1D CK1D P48730 human ATOH1 11921 P48985 Atoh1 mouse S334 57761903 TsPRsHRsDGEFsPH X +CSNK1D CK1D P48730 human TDP-43 23435 Q13148 TARDBP human S389 6855917 AIGWGsAsNAGsGsG X +CSNK1D CK1D P48730 human Cas-L 4739 Q14511 NEDD9 human S780 348338200 RNkVMNSsNQLCEQL CAS_C X +CSNK1D CK1D P48730 human FOXO1A 84482 G3V7R4 Foxo1 rat S319 449114 SsNAsTIsGRLsPIM X X +CSNK1D CK1D P48730 human MDM2 4193 Q00987 MDM2 human S290 17342600 AGEsDtDsFEEDPEI X +CSNK1D CK1D P48730 human YAP1 iso2 10413 P46937-2 YAP1 human S384 9764918 SRDEsTDsGLsMSSY X +CSNK1D CK1D P48730 human MDM2 4193 Q00987 MDM2 human S118 15714603 NQQESSDsGTsVSEN X +CSNK1D CK1D P48730 human TDP-43 23435 Q13148 TARDBP human S292 6855918 NQGGFGNsrGGGAGL X +CSNK1D CK1D P48730 human PER2 8864 O15055 PER2 human S665 470017 GKAEsVAsLTsQCsY X +CSNK1D CK1D P48730 human LZTS2 84445 Q9BRK4 LZTS2 human S277 1871717500 HsDsGRsssSKsTGS X +CSNK1D CK1D P48730 human TDP-43 23435 Q13148 TARDBP human S92 6855902 MDEtDAssAVkVKRA X +CSNK1D CK1D P48730 human APC 324 P25054 APC human S1505 452096 DGFsCsssLsALsLD APC_r X +CSNK1D CK1D P48730 human FMR1 14265 P35922 Fmr1 mouse S499 469583 NSEAsNAsETESDHR FXMRP1_C_core X +CSNK1D CK1D P48730 human DVL2 13543 Q60838 Dvl2 mouse S591 27623904 QHSEGSRssGstRsD Dsh_C X +CSNK1D CK1D P48730 human MTSS1 9788 O43312 MTSS1 human S322 4763951 SSVsSHDsGFISQDA X +CSNK1D CK1D P48730 human MDM2 4193 Q00987 MDM2 human S253 2132107 sVEFEVEsLDsEDYs X +CSNK1D CK1D P48730 human FGFBP1 281812 Q9MZ06 FGFBP1 cow S36 487543 NRRGSKAsADESLAL FGF-BP1 X +CSNK1D CK1D P48730 human KIR3DL1 3811 P43629 KIR3DL1 human S388 990303 RTANsEDsDEQDPEE X +CSNK1D CK1D P48730 human PSEN2 5664 P49810 PSEN2 human S327 448564 DPEMEEDsYDsFGEP Presenilin; Presenilin X +CSNK1D CK1D P48730 human hnRNP P2 2521 P35637 FUS human S164 1878186702 QQNQYNssSGGGGGG X +CSNK1D CK1D P48730 human MDM2 4193 Q00987 MDM2 human S121 15714602 ESSDsGTsVSENRCH X X +CSNK1D CK1D P48730 human Tau iso8 4137 P10636-8 MAPT human T205 447933 ssPGsPGtPGsRsRt X X 25377; 43964; 53001; 49561; 20060; 33032; 30505; 20739; 98160 +CSNK1D CK1D P48730 human KIR3DL1 3811 P43629 KIR3DL1 human S385 990304 AGNRTANsEDsDEQD X +CSNK1D CK1D P48730 human ATOH1 11921 P48985 Atoh1 mouse S331 57761908 NsKTsPRsHRsDGEF X +CSNK1D CK1D P48730 human MDM2 4193 Q00987 MDM2 human S240 454919 GDWLDQDsVsDQFsV X +CSNK1D CK1D P48730 human MDM2 4193 Q00987 MDM2 human T279 17342603 DDEVyQVtVyQAGEs X +Map3k3 MEKK3 Q61084 mouse MKK3 5606 P46734 MAP2K3 human S218 448276 IsGyLVDsVAKtMDA Pkinase X 9231; 9236; 12280 +Map3k3 MEKK3 Q61084 mouse p47phox 17969 Q09014 Ncf1 mouse S208 465580 KRGWVPAsYLEPLDS X +MKNK1 Mnk1 iso2 Q9BUB5-2 human EIF4E 1977 P06730 EIF4E human S209 447776 DtATksGsttKNRFV X 9741 +Prkcq PKCT Q02111 mouse PDK1 18607 Q9Z2A0 Pdpk1 mouse S532 5938009 TYYLMDPsGNAHKWC PH_3 X +Prkcq PKCT Q02111 mouse PKCT 5588 Q04759 PRKCQ human T219 457380 SAINSREtMFHkERF X +Prkcq PKCT Q02111 mouse NDRG2 29811 Q9QYG0 Ndrg2 mouse S332 451010 LsRsRtAsLtsAAsI X +Prkcq PKCT Q02111 mouse SRC-1 17977 P70365 Ncoa1 mouse S1271 396518803 MPVPPPQssLLQQTP DUF1518 X +Prkcq PKCT Q02111 mouse PDK1 18607 Q9Z2A0 Pdpk1 mouse S504 5938008 LKGEIPWsQELRPEA PH_3 X +Prkcq PKCT Q02111 mouse Radixin 19684 P26043 Rdx mouse T564 448374 AGRDKYKtLRQIRQG ERM_C X 3141; 3726; 32600 +Prkcq PKCT Q02111 mouse sialophorin 20737 P15702 Spn mouse S347 477870 RRKsRQGsLVLEELK X +Prkcq PKCT Q02111 mouse SRC-1 17977 P70365 Ncoa1 mouse S1272 396518804 PVPPPQssLLQQTPP DUF1518 X +Prkcq PKCT Q02111 mouse IRS1 3667 P35568 IRS1 human S1101 453434 GCRRRHssEtFsStP X X +Prkcq PKCT Q02111 mouse IRS1 16367 P35569 Irs1 mouse S1097 453434 GCRRRHssEtFSAPt X 2385 +Prkcq PKCT Q02111 mouse KLF1 16596 P46099 Klf1 mouse S50 31953300 PPNPTGPsLHVSLkS X X +Prkcq PKCT Q02111 mouse CD4 12504 P06332 Cd4 mouse S432 451188 QRQAARMsQIKRLLS Tcell_CD4_C X +Prkcq PKCT Q02111 mouse NDRG2 171114 Q8VBU2 Ndrg2 rat S332 451010 LsRsRtAsLtsAAsI X +HSPA5 GRP78 P11021 human GRP78 3309 P11021 HSPA5 human T229 2876500 VFDLGGGtFDVSLLT HSP70 X +KSR2 KSR2 Q6VAB6 human MEK1 100009316 P29678 MAP2K1 rabbit S24 20910000 GSAVNGTsSAETNLE X +KSR2 KSR2 Q6VAB6 human MEK1 100009316 P29678 MAP2K1 rabbit S72 448585 DDDFEKIsELGAGNG Pkinase X +KSR2 KSR2 Q6VAB6 human MEK1 100009316 P29678 MAP2K1 rabbit S218 448514 VSGQLIDsMANsFVG Pkinase X 9121; 3958; 9154; 86128 +KSR2 KSR2 Q6VAB6 human MEK1 100009316 P29678 MAP2K1 rabbit S222 448513 LIDsMANsFVGTRSY Pkinase X 2338; 9121; 3958; 9154; 16211; 86128; 16780; 75262 +Pdgfrb PDGFRB Q05030 rat PDGFRB Q05030 Pdgfrb rat Y1020 447523 PNETDNDyIIPLPDP X +Pdgfrb PDGFRB Q05030 rat PDGFRB Q05030 Pdgfrb rat Y578 447521 VSSDGHEyIYVDPVQ X +Pdgfrb PDGFRB Q05030 rat PDGFRB Q05030 Pdgfrb rat Y750 447508 SKDESVDyVPMLDMK PK_Tyr_Ser-Thr X +Pdgfrb PDGFRB Q05030 rat PDGFRB Q05030 Pdgfrb rat Y715 447524 CPPSTELySNALPVG PK_Tyr_Ser-Thr X +Camk2b CAMK2B P08413 rat GSK3B 84027 P18266 Gsk3b rat S9 449111 SGRPRTTsFAESCKP X 9336; 9331; 9327; 9323; 9322; 9325; 5558; 8566; 79774; 8466; 25462; 14026; 14332; 14310; 14630 +Camk2b CAMK2B P08413 rat CAMK2A 25400 P11275 Camk2a rat T286 447797 sCMHRQEtVDCLkkF X 12716 +Camk2b CAMK2B P08413 rat SAPAP1 65040 P97836 Dlgap1 rat S389 481511 YLKATQPsLTELTTL X +Camk2b CAMK2B P08413 rat CAMK2B 24245 P08413 Camk2b rat S327 48915806 ttAPAtMstAAsGtt X +Camk2b CAMK2B P08413 rat CAMK2B 24245 P08413 Camk2b rat T400 2030268 EssDsTNttIEDEDA X +Camk2b CAMK2B P08413 rat CAMK2B 24245 P08413 Camk2b rat T287 450048 sMMHRQEtVECLkkF X X 12716 +Camk2b CAMK2B P08413 rat Spinophilin 84686 O35274 Ppp1r9b rat S100 448729 LsLPRAssLNENVDH X +Camk2b CAMK2B P08413 rat CAMK2B 24245 P08413 Camk2b rat T307 2020797 LkGAILttMLAtRNF X +Camk2b CAMK2B P08413 rat SAPAP1 65040 P97836 Dlgap1 rat S691 12130200 KTSSKFQsVGVQVEE GKAP X +Camk2b CAMK2B P08413 rat CAMK2B 24245 P08413 Camk2b rat T382 48915804 AALEPQttVIHNPVD X +Camk2b CAMK2B P08413 rat SynGAP 192117 Q9QUH6 Syngap1 rat S1118 481550 kEGsIGGsGGsGGGG DUF3498 X +Camk2b CAMK2B P08413 rat AMPKA1 65248 P54645 Prkaa1 rat T183 448786 SDGEFLRtsCGSPNY Pkinase X 2535; 2531; 4188; 5256; 50081; 74281 +Camk2b CAMK2B P08413 rat CAMK2B 24245 P08413 Camk2b rat T254 2048065 NLINQMLtINPAkRI Pkinase X +Camk2b CAMK2B P08413 rat CAMK2B 24245 P08413 Camk2b rat T334 48915802 stAAsGttMGLVEQA X +Camk2b CAMK2B P08413 rat CAMK2B 24245 P08413 Camk2b rat S371 2020829 AITsPkGsLPPAALE X X +Camk2b CAMK2B P08413 rat CAMK2B 24245 P08413 Camk2b rat T311 15719513 ILttMLAtRNFsVGR X +Camk2b CAMK2B P08413 rat CAMK2B 24245 P08413 Camk2b rat S363 3558927 TNsTkNSsAITsPkG X +Camk2b CAMK2B P08413 rat SynGAP 192117 Q9QUH6 Syngap1 rat S1121 481551 sIGGsGGsGGGGGGG DUF3498 X +Camk2b CAMK2B P08413 rat SAPAP3 286923 P97838 Dlgap3 rat S930 481288 GVPVKERsLDsVDRQ GKAP X +Camk2b CAMK2B P08413 rat SHANK3 59312 Q9JLU4 Shank3 rat S1511 2048965 QLNKDTRsLGEEPVG X +Camk2b CAMK2B P08413 rat SynGAP 192117 Q9QUH6 Syngap1 rat S766 4792737 MMRDLNssIDLQSFM DUF3498 X +Camk2b CAMK2B P08413 rat CAMK2B 24245 P08413 Camk2b rat T320 48915800 NFsVGRQttAPAtMs X +Camk2b CAMK2B P08413 rat CAMK2B 24245 P08413 Camk2b rat S343 7446037 GLVEQAksLLNkkAD X +Camk2b CAMK2B P08413 rat CAMK2A 25400 P11275 Camk2a rat S314 451708 MLAtRNFsGGKSGGN X +Camk2b CAMK2B P08413 rat CDC20 64515 Q62623 Cdc20 rat S51 20653800 RAANRSHsAGRTPGR X X 8038 +Camk2b CAMK2B P08413 rat CAMK2A 25400 P11275 Camk2a rat T253 451571 DLINkMLtINPskRI Pkinase X +Camk2b CAMK2B P08413 rat LRRC7 117284 P70587 Lrrc7 rat S1392 481330 IQTKGQRsMDGYPEQ X +Camk2b CAMK2B P08413 rat CAMK2B 24245 P08413 Camk2b rat S315 451707 MLAtRNFsVGRQttA X +Camk2b CAMK2B P08413 rat CAMK2B 24245 P08413 Camk2b rat T381 2020833 PAALEPQttVIHNPV X +Camk2b CAMK2B P08413 rat CAMK2B 24245 P08413 Camk2b rat T401 4705443 ssDsTNttIEDEDAK X +Camk2b CAMK2B P08413 rat CAMK2B 24245 P08413 Camk2b rat T325 48915805 RQttAPAtMstAAsG X +Camk2b CAMK2B P08413 rat CAMK2B 24245 P08413 Camk2b rat T328 34358436 tAPAtMstAAsGttM X +Camk2b CAMK2B P08413 rat CAMK2B 24245 P08413 Camk2b rat S280 4705429 CQRstVAsMMHRQEt X +Camk2b CAMK2B P08413 rat LRRC7 117284 P70587 Lrrc7 rat T827 12157800 PLELEQstHRHtPET X +Camk2b CAMK2B P08413 rat CAMK2B 24245 P08413 Camk2b rat S331 48915803 AtMstAAsGttMGLV X X +Camk2b CAMK2B P08413 rat SHANK3 59312 Q9JLU4 Shank3 rat S694 2022961 TLTLRSKsMTAELEE X +Camk2b CAMK2B P08413 rat Spinophilin 84686 O35274 Ppp1r9b rat S99 2023901 RLsLPRAssLNENVD X +Camk2b CAMK2B P08413 rat CAMK2B 24245 P08413 Camk2b rat T321 2048069 FsVGRQttAPAtMst X +Camk2b CAMK2B P08413 rat CAMK2B 24245 P08413 Camk2b rat T306 451706 kLkGAILttMLAtRN X +Camk2b CAMK2B P08413 rat SynGAP 192117 Q9QUH6 Syngap1 rat S1073 469613 PPLQRGKsQQLTVsA DUF3498 X +Camk2b CAMK2B P08413 rat CAMK2B 24245 P08413 Camk2b rat T333 48915801 MstAAsGttMGLVEQ X +Camk2b CAMK2B P08413 rat SynGAP 192117 Q9QUH6 Syngap1 rat S765 4792731 yMMRDLNssIDLQSF DUF3498 X +Camk2b CAMK2B P08413 rat SAPAP2 116681 P97837 Dlgap2 rat S1012 2049577 FPITREKsLDLPDRQ GKAP X +Camk2b CAMK2B P08413 rat LRRC7 117284 P70587 Lrrc7 rat S826 2049457 VPLELEQstHRHtPE X +Camk2b CAMK2B P08413 rat GSK3A 50686 P18265 Gsk3a rat S21 448584 SGRARtssFAEPGGG X 9337; 9316; 9331; 9327; 8452; 8566 +Camk2b CAMK2B P08413 rat SAPAP1 65040 P97836 Dlgap1 rat S947 481515 APLIRERsLESSQRQ GKAP X +Camk2b CAMK2B P08413 rat CAMK2B 24245 P08413 Camk2b rat S397 485905 GIKEssDsTNttIED X +Camk2b CAMK2B P08413 rat SHANK1 78957 Q9WV48 Shank1 rat S783 12130201 RLPPPAIsLRSKSMT X +Camk2b CAMK2B P08413 rat CAMK2B 24245 P08413 Camk2b rat S367 456904 kNSsAITsPkGsLPP X +Camk2b CAMK2B P08413 rat SynGAP 192117 Q9QUH6 Syngap1 rat S1114 481549 QsLSkEGsIGGsGGs DUF3498 X +Camk2b CAMK2B P08413 rat CAMK2B 24245 P08413 Camk2b rat S358 15719516 GVkPQTNsTkNSsAI X +Csnk1d CK1D Q06486 rat DARPP-32 360616 Q6J4I0 Ppp1r1b rat S137 448046 EEDEEEDsQAEVLKG DARPP-32 X +Csnk1d CK1D Q06486 rat DARPP-32 360616 Q6J4I0 Ppp1r1b rat T34 448047 MIRRRRPtPALLFRV DARPP-32 X 12438 +Irak1 IRAK1 Q62406 mouse IRAK1BP1 65099 Q9ESJ7 Irak1bp1 mouse S234 12524610 TVQQKIKsAtIHAAs SIMPL X +Irak1 IRAK1 Q62406 mouse STAT3 20848 P42227 Stat3 mouse S727 448191 NtIDLPMsPRTLDSL X 9134; 9136; 34911; 94994; 49081; 58978; 87544; 71958; 50804 +Irak1 IRAK1 Q62406 mouse IRAK1BP1 65099 Q9ESJ7 Irak1bp1 mouse S63 12524608 GAAEVsAsPDRALVT SIMPL X +Irak1 IRAK1 Q62406 mouse IRAK1BP1 65099 Q9ESJ7 Irak1bp1 mouse T236 12524611 QQKIKsAtIHAAsKV SIMPL X +Irak1 IRAK1 Q62406 mouse IRAK1BP1 65099 Q9ESJ7 Irak1bp1 mouse T246 12524605 AAsKVFItFEVKGKE SIMPL X +Irak1 IRAK1 Q62406 mouse IRAK1BP1 65099 Q9ESJ7 Irak1bp1 mouse S61 12524607 VsGAAEVsAsPDRAL SIMPL X +Irak1 IRAK1 Q62406 mouse IRAK1BP1 65099 Q9ESJ7 Irak1bp1 mouse S55 12524606 GAREVHVsGAAEVsA SIMPL X +Irak1 IRAK1 Q62406 mouse IRAK1BP1 65099 Q9ESJ7 Irak1bp1 mouse S241 12524609 sAtIHAAsKVFItFE SIMPL X +PDK4 PDHK4 Q16654 human PDHA1 5160 P08559 PDHA1 human S300 448259 sMsDPGVsyRtREEI E1_dh X +PDK4 PDHK4 Q16654 human PDHA1 18597 P35486 Pdha1 mouse S293 448258 TYRyHGHsMsDPGVs E1_dh X 31866; 37115; 48447 +PDK4 PDHK4 Q16654 human PDHA1 18597 P35486 Pdha1 mouse S300 448259 sMsDPGVsyRtREEI E1_dh X +PDK4 PDHK4 Q16654 human PDHA1 5160 P08559 PDHA1 human S293 448258 TYRyHGHsMsDPGVs E1_dh X X 31866; 37115; 48447 +PDK4 PDHK4 Q16654 human PDHA2 5161 P29803 PDHA2 human S298 458870 sMsDPGVsyRtREEI E1_dh X +PDK4 PDHK4 Q16654 human myogenin 17928 P12979 Myog mouse T57 1880114102 LEEKGLGtPEHCPGQ X +PDK4 PDHK4 Q16654 human PDHA1 5160 P08559 PDHA1 human S232 448257 NRyGMGtsVERAAAs E1_dh X 15289 +PDK4 PDHK4 Q16654 human PDHA2 5161 P29803 PDHA2 human S291 458869 TYRyHGHsMsDPGVs E1_dh X 31866; 37115; 48447 +PDK4 PDHK4 Q16654 human myogenin 17928 P12979 Myog mouse S43 1880114100 ERTELSLsPEARGPL X +PLK4 PLK4 O00444 human HAND1 15110 Q64279 Hand1 mouse T107 12518701 PKKERRRtEsINSAF HLH X +PLK4 PLK4 O00444 human NEDD1 121441 Q8NHV4 NEDD1 human S338 25533005 AsGGVQNsGIVREAP X X +PLK4 PLK4 O00444 human PLK4 10733 O00444 PLK4 human T170 480636 MPHEkHYtLCGtPNy Pkinase X +PLK4 PLK4 O00444 human PLK4 10733 O00444 PLK4 human S305 12122401 sstsIsGsLFDKRRL X X +PLK4 PLK4 O00444 human CENPJ 55835 Q9HC77 CENPJ human S595 14918201 IsFSSNSsFVLKILE X X +PLK4 PLK4 O00444 human HAND1 15110 Q64279 Hand1 mouse S109 12518702 KERRRtEsINSAFAE HLH X +PLK4 PLK4 O00444 human NEDD1 121441 Q8NHV4 NEDD1 human S404 25533002 sFDDtGKssLGDMFs X X +PLK4 PLK4 O00444 human CEP131 22994 Q9UPN4 CEP131 human S78 1211822 NNLRRsNsttQVSQP X X +PLK4 PLK4 O00444 human STIL 6491 Q15468 STIL human S428 1868450205 QPSVPELsLVLDGNF STIL_N X X +PLK4 PLK4 O00444 human NEDD1 121441 Q8NHV4 NEDD1 human S325 15421692 PTTVNKRsVNVNAAs X X +PLK4 PLK4 O00444 human PCM-1 5108 Q15154 PCM1 human S372 11536118 RRQAEsLsLtREVsQ X +PLK4 PLK4 O00444 human NEDD1 121441 Q8NHV4 NEDD1 human T23 1871432200 IWDASSMtLVDKFNP WD40 X X +PLK4 PLK4 O00444 human NEDD1 121441 Q8NHV4 NEDD1 human T303 1871432201 CIAFQYStVLTKSSL X X +PLK4 PLK4 O00444 human PLK4 10733 O00444 PLK4 human S22 21691605 GNLLGKGsFAGVYRA Pkinase X +PLK4 PLK4 O00444 human ARP2 10097 P61160 ACTR2 human T238 36440501 QKLALEttVLVESYT Actin X X +PLK4 PLK4 O00444 human PLK4 10733 O00444 PLK4 human Y177 21691606 tLCGtPNyISPEIAT Pkinase X +PLK4 PLK4 O00444 human CEP131 22994 Q9UPN4 CEP131 human T205 1868722300 PLkSSNQtAPsLNNI X +PLK4 PLK4 O00444 human NEDD1 121441 Q8NHV4 NEDD1 human S568 25533011 AGVAssLsEkIADsI X X +PLK4 PLK4 O00444 human FBXW5 54461 Q969U6 FBXW5 human S151 20831310 SQFNKDDsLLLASGV X X +PLK4 PLK4 O00444 human NEK7 140609 Q8TDX7 NEK7 human S204 3207291 VGtPyyMsPERIHEN Pkinase X +PLK4 PLK4 O00444 human ARP2 10097 P61160 ACTR2 human T237 36440502 EQKLALEttVLVESY Actin X X +PLK4 PLK4 O00444 human PPP1R16B 26051 Q96T49 PPP1R16B human S69 17549547 KKVSFEAsVALLEAS X +PLK4 PLK4 O00444 human STIL 6491 Q15468 STIL human S1116 17400758 LIsPNNMsFAtkKYM X X +PLK4 PLK4 O00444 human CP110 9738 O43303 CCP110 human S98 126835300 VRKAPNAsDFDQWEM CaM_bind X X +PLK4 PLK4 O00444 human CEP131 22994 Q9UPN4 CEP131 human S21 41451326 sPAGVDLsLTGLPPP X X +Mark4 MARK4 Q8CIP4 mouse MAP4 17758 P27546 Map4 mouse S1046 470381 KAQAKVGsLDNVGHL Tubulin-binding X +Mark4 MARK4 Q8CIP4 mouse MAP4 17758 P27546 Map4 mouse S914 1210622 SVRsKVGstENIKHQ Tubulin-binding X +Tbk1 TBK1 NP_001100256 rat EXOC8 245709 O54924 Exoc8 rat S28 480112 RLYVKQLsQQsDGDR Vps51 X +Tbk1 TBK1 NP_001100256 rat SQSTM1 113894 O08623 Sqstm1 rat S402 22264800 ESLSQMLsMGFSDEG UBA_5 X 39786 +Tbk1 TBK1 NP_001100256 rat EXOC8 245709 O54924 Exoc8 rat S670 56663140 TFIRQNAsFLyDTVL X +Tbk1 TBK1 NP_001100256 rat EXOC8 245709 O54924 Exoc8 rat T313 454459 EAEEELAtPEAEEEK X +Tbk1 TBK1 NP_001100256 rat EXOC8 245709 O54924 Exoc8 rat S92 182950100 HLLTEQKssLESIPL Vps51 X +Tbk1 TBK1 NP_001100256 rat EXOC8 245709 O54924 Exoc8 rat S93 182950101 LLTEQKssLESIPLA Vps51 X +Tbk1 TBK1 NP_001100256 rat EXOC8 245709 O54924 Exoc8 rat S31 40510667 VKQLsQQsDGDRDLQ Vps51 X +Tbk1 TBK1 NP_001100256 rat EXOC8 245709 O54924 Exoc8 rat S366 182950104 EDKPSPPsVKELRAK Exo84_C X +Tbk1 TBK1 NP_001100256 rat EXOC8 245709 O54924 Exoc8 rat S505 25291117 QVFDSKEsLSTAAEC Exo84_C X +Tbk1 TBK1 NP_001100256 rat INSR 24954 P15127 Insr rat S1034 454090 LRELGQGsFGMVYEG PK_Tyr_Ser-Thr X +Tbk1 TBK1 NP_001100256 rat EXOC8 245709 O54924 Exoc8 rat S276 182950103 EETKRALsDKRRREQ X +Tbk1 TBK1 NP_001100256 rat EXOC8 245709 O54924 Exoc8 rat T152 182950102 GEEGKQRtLTTLLEK X +CIT CRIK O14578 human GLI2 2736 P10070 GLI2 human S149 10414536 IsAArGLsPADVAQE X +CIT CRIK O14578 human MRLC1 296313 Q64122 Myl9 rat S20 1863500 KRPQSAtsNVFAMFD X 3674; 3671; 3675; 95777 +CIT CRIK O14578 human MRLC1 10398 P24844 MYL9 human T19 1863501 KKRPQRAtsNVFAMF X 3674; 95777 +CIT CRIK O14578 human MRLC1 296313 Q64122 Myl9 rat T19 1863501 KKRPQSAtsNVFAMF X 3674; 95777 +CIT CRIK O14578 human MRLC1 10398 P24844 MYL9 human S20 1863500 KRPQRAtsNVFAMFD X 3674; 3671; 3675; 95777 +Flt3 FLT3 Q00342 mouse FLT3 14255 Q00342 Flt3 mouse Y592 448190 PLDNEyFyVDFRDYE X 3466; 3461; 3464 +AURKC AurC Q9UQB9 human H3 8350 P68431 H3C1 human S10 455676 tkQtArkstGGkAPr Histone X 9701; 9711; 9606; 3465; 3642; 3377; 3475; 3458; 5764; 47398; 8481; 8552; 53348; 29237; 66065; 43185; 64522; 52725 +AURKC AurC Q9UQB9 human IkB-alpha 4792 P25963 NFKBIA human S262 1873119302 QLTWGRPsTRIQQQL X X +AURKC AurC Q9UQB9 human AurC 20871 O88445 Aurkc mouse T171 455456 TPSLRRKtMCGtLDY Pkinase X 2914; 13464; 8525 +AURKC AurC Q9UQB9 human IkB-alpha 4792 P25963 NFKBIA human S32 448203 LLDDRHDsGLDsMkD X X 5210; 2859; 9246; 5209 +AURKC AurC Q9UQB9 human INCENP 3619 Q9NQS7 INCENP human S894 450468 RYHKRtssAVWNsPP X +AURKC AurC Q9UQB9 human Survivin 332 O15392 BIRC5 human S20 485776 FLkDHRIstFkNWPF BIR X +AURKC AurC Q9UQB9 human TACC1 6867 O75410 TACC1 human S228 10407015 ELVPsRRsKLRKPkP X +AURKC AurC Q9UQB9 human INCENP 3619 Q9NQS7 INCENP human T892 450466 KPRYHKRtssAVWNs X +AURKC AurC Q9UQB9 human IkB-alpha 4792 P25963 NFKBIA human S63 1873119300 PQEVPRGsEPWkQQL X X +AURKC AurC Q9UQB9 human INCENP 16319 Q9WU62 Incenp mouse S862 450468 RYHKRtssAVWNsPP X +AURKC AurC Q9UQB9 human INCENP 3619 Q9NQS7 INCENP human S893 450467 PRYHKRtssAVWNsP X +AURKC AurC Q9UQB9 human INCENP 16319 Q9WU62 Incenp mouse S861 450467 TRYHKRtssAVWNsP X +PRKCB PKCB P05126-2 cow MARCKS 613548 P12624 MARCKS cow S162 447787 KRFsFKKsFKLsGFs MARCKS X 11992 +PRKCB PKCB P05126-2 cow TOP2A 7153 P11388 TOP2A human T1343 448763 FsDFDEKtDDEDFVP X +PRKCB PKCB P05126-2 cow MARCKS 613548 P12624 MARCKS cow S169 451837 sFKLsGFsFKKNKKE MARCKS X 8722 +PRKCB PKCB P05126-2 cow GJA1 24392 P08050 Gja1 rat S368 447813 QRPssRAssRAssRP X 3511; 52559 +PRKCB PKCB P05126-2 cow MARCKS 613548 P12624 MARCKS cow S158 447786 KKKKKRFsFKKsFKL MARCKS X 11992 +Brsk1 BRSK1 Q5RJI5 mouse ERC2 259269 Q8K3M6 Erc2 rat S45 4740442 GGTGKTLsMENIQSL X +MAP2K7 MKK7 O14733 human JNK3 iso2 5602 P53779-2 MAPK10 human T221 448034 AGTSFMMtPyVVTRY Pkinase X +MAP2K7 MKK7 O14733 human JNK2 5601 P45984 MAPK9 human T183 447649 ACtNFMMtPyVVtRY Pkinase X X +MAP2K7 MKK7 O14733 human JNK1 5599 P45983 MAPK8 human Y185 447645 tsFMMtPyVVtRYYR Pkinase X X 5136; 4668; 4671; 9257; 9255; 9251; 4306; 5755; 16014; 58328 +MAP2K7 MKK7 O14733 human JNK2 26420 Q9WTU6 Mapk9 mouse T183 447649 ACTNFMMtPyVVtRY Pkinase X +MAP2K7 MKK7 O14733 human JNK2 26420 Q9WTU6 Mapk9 mouse Y185 447652 TNFMMtPyVVtRYYR Pkinase X +MAP2K7 MKK7 O14733 human JNK2 5601 P45984 MAPK9 human S407 447648 STEQtLAsDTDSSLD X +MAP2K7 MKK7 O14733 human JNK1 5599 P45983 MAPK8 human T183 447643 AGtsFMMtPyVVtRY Pkinase X X 5136; 4668; 4671; 9257; 9255; 9251; 4306; 5755; 16014; 58328 +MAP2K7 MKK7 O14733 human FADD 8772 Q13158 FADD human S194 447653 QNRsGAMsPMsWNsD X 2781 +MAP2K7 MKK7 O14733 human JNK2 5601 P45984 MAPK9 human T404 447650 SSMSTEQtLAsDTDS X +MAP2K7 MKK7 O14733 human JNK1 iso2 5599 P45983-2 MAPK8 human T183 447643 AGTSFMMtPyVVTRY Pkinase X 5136; 9255; 9251; 4306; 5755; 16014 +MAP2K7 MKK7 O14733 human JNK3 5602 P53779 MAPK10 human T221 448034 AGtsFMMtPyVVtRY Pkinase X 4668; 58328 +Tnni3k TNNI3K Q7TQP6 rat TNNI3 29248 P23693 Tnni3 rat S43 450690 AKKKSKIsAsRKLQL X +Tnni3k TNNI3K Q7TQP6 rat TNNI3 29248 P23693 Tnni3 rat T144 451483 RGKFkRPtLRRVRIs Troponin X +FRK FRK P42685 human YAP1 10413 P46937 YAP1 human Y407 473004 sGLsMsSySVPRtPD X +FRK FRK P42685 human BRCA1 672 P38398 BRCA1 human Y1552 50684000 HDLtEtSyLPRQDLE X X +FRK FRK P42685 human YAP1 10413 P46937 YAP1 human Y444 54390605 QQNRFPDyLEAIPGT X +FRK FRK P42685 human YAP1 10413 P46937 YAP1 human Y391 15565111 PFLNsGtyHSRDEst X +FRK FRK P42685 human Fos 14281 P01101 Fos mouse T232 448491 GGLPEAStPESEEAF X +FRK FRK P42685 human PTEN 5728 P60484 PTEN human Y336 7596704 NKDkANRyFSPNFKV PTEN_C2 X +PIK3CD PIK3CD O00329 human PIK3CD 5293 O00329 PIK3CD human S1039 466429 NWLAHNVsKDNRQ__ X +STK16 MPSK1 O75716 human sarcolipin 100009246 P42532 SLN rabbit T5 459214 ___MERStRELCLNF Sarcolipin X +STK16 MPSK1 O75716 human MPSK1 8576 O75716 STK16 human S197 2028406 AAQRCTIsyRAPELF Pkinase X +STK16 MPSK1 O75716 human MPSK1 8576 O75716 STK16 human Y198 2028407 AQRCTIsyRAPELFS Pkinase X X +STK16 MPSK1 O75716 human MPSK1 8576 O75716 STK16 human T185 2028405 EGSRQALtLQDWAAQ Pkinase X +STK16 MPSK1 O75716 human DRG1 4733 Q9Y295 DRG1 human T101 2028404 yEFTTLTtVPGVIRY MMR_HSR1 X +Pak1 PAK1 O88643 mouse ARPC1B 10095 O15143 ARPC1B human T21 10349703 HAWNkDRtQIAICPN X +Pak1 PAK1 O88643 mouse LC8 56455 P63168 Dynll1 mouse S88 454241 VAILLFKsG______ Dynein_light X X +Pak1 PAK1 O88643 mouse Vimentin 7431 P08670 VIM human S66 451765 GVyAtrssAVrLrss Filament_head X +Pak1 PAK1 O88643 mouse Vimentin 7431 P08670 VIM human S51 449416 LrPstsrsLyAssPG Filament_head X X +Pak1 PAK1 O88643 mouse STAT5A 20850 P42230 Stat5a mouse S779 448750 DsLDARLsPPAGLFT X X +Pak1 PAK1 O88643 mouse FLNA 192176 Q8BTM8 Flna mouse S2152 451357 TRRRRAPsVANIGsH Filamin X 4761 +Pak1 PAK1 O88643 mouse PAK1 18479 O88643 Pak1 mouse S21 448174 APPMRNTsTMIGAGS X +Pak1 PAK1 O88643 mouse Vimentin 7431 P08670 VIM human S73 449025 sAVrLrssVPGVRLL Filament_head X X +Pak1 PAK1 O88643 mouse Vimentin 7431 P08670 VIM human S39 451766 ttstrtysLGsALrP Filament_head X 13614 +Pak1 PAK1 O88643 mouse Vimentin 7431 P08670 VIM human S26 451767 GtAsrPsssrsyVtt Filament_head X +SLK SLK Q9H2G2 human Radixin 5962 P35241 RDX human T564 448374 AGRDKyKtLRQIRQG ERM_C X 3141; 3726; 32600 +SLK SLK Q9H2G2 human Ezrin 7430 P15311 EZR human T567 448104 QGRDkyKtLRQIRQG ERM_C X 3141; 3726; 32600 +SLK SLK Q9H2G2 human SLK 9748 Q9H2G2 SLK human T183 1211366 VsAkNtRtIQRRDsF Pkinase X +SLK SLK Q9H2G2 human PXN 19303 Q8VI36 Pxn mouse S250 3653284 SsPQRVTsSQQQTRI Paxillin X +SLK SLK Q9H2G2 human Moesin 4478 P26038 MSN human T558 447706 LGRDKyKtLRQIRQG ERM_C X 3141; 3726; 32600 +SLK SLK Q9H2G2 human SLK 9748 Q9H2G2 SLK human S189 468769 RtIQRRDsFIGtPyW Pkinase X +CDK16 CDK16 Q00536 human PKAR1A 5573 P10644 PRKAR1A human S83 450936 DsREDEIsPPPPNPV X X +CDK16 CDK16 Q00536 human PRC1 9055 O43663 PRC1 human T481 483541 RrGLAPNtPGkARkL X X +CDK16 CDK16 Q00536 human NSF 18195 P46460 Nsf mouse S569 460358 FPFIKICsPDKMIGF AAA X +CDK16 CDK16 Q00536 human p27Kip1 1027 P46527 CDKN1B human S10 447874 NVRVSNGsPsLErMD X X +CDK16 CDK16 Q00536 human CBCP1 219771 Q8ND76 CCNY human S336 41655502 NLtLPRWsPAIIS__ X +Map3k2 MEKK2 Q61083 mouse MEKK2 26405 Q61083 Map3k2 mouse T283 28761201 EYNDGRKtFPRARRT X +Map3k2 MEKK2 Q61083 mouse CTNNB1 12387 Q02248 Ctnnb1 mouse S675 457120 QDykKRLsVELtSsL X 9567; 4176; 68076 +Map3k2 MEKK2 Q61083 mouse MEKK2 26405 Q61083 Map3k2 mouse S520 1869000 LsGtGMKsVTGTPYW Pkinase X +Sgk1 SGK1 Q06226 rat SRF 501099 NP_001102772 Srf rat S99 447692 RGLKRSLsEMELGVV X +Sgk1 SGK1 Q06226 rat SRF 501099 NP_001102772 Srf rat S75 451803 AGALYsGsEGDSESG X +Sgk1 SGK1 Q06226 rat MKK4 26398 P47809 Map2k4 mouse S78 447655 IERLRTHsIESsGKL X 9155 +Sgk1 SGK1 Q06226 rat SRF 501099 NP_001102772 Srf rat S73 451802 PTAGALYsGsEGDSE X +Sgk1 SGK1 Q06226 rat ROMK 24521 P35560 Kcnj1 rat S44 449605 RQRARLVsKEGRCNI IRK X +ERBB2 HER2 P04626 human PUMA 27113 Q9BXH1 BBC3 human Y172 29674705 PsPWRVLyNLIMGLL PUMA X X +ERBB2 HER2 P04626 human HER2 2064 P04626 ERBB2 human Y1222 448675 PAFDNLyyWDQDPPE X X 2243; 2249; 91415 +ERBB2 HER2 P04626 human DOCK7 85440 Q96N67 DOCK7 human Y1257 2756301 METVPQLyDFTETHN X X +ERBB2 HER2 P04626 human PUMA 27113 Q9BXH1 BBC3 human Y58 29674706 PTLLPAAyLCAPTAP PUMA X X +ERBB2 HER2 P04626 human HER2 2064 P04626 ERBB2 human Y1023 448682 DLVDAEEyLVPQQGF X +ERBB2 HER2 P04626 human PLXNB1 5364 O43157 PLXNB1 human Y1708 3413438 DSVGEPLyMLFRGIK Plexin_cytopl X +ERBB2 HER2 P04626 human PUMA 27113 Q9BXH1 BBC3 human Y152 29674707 ADDLNAQyERRRQEE PUMA X X +ERBB2 HER2 P04626 human PLXNB1 5364 O43157 PLXNB1 human Y1732 11485312 SVtGKAKyTLNDNRL Plexin_cytopl X +ERBB2 HER2 P04626 human HER2 2064 P04626 ERBB2 human Y877 448694 LDIDEtEyHADGGkV PK_Tyr_Ser-Thr X 2241 +ERBB2 HER2 P04626 human CTNNB1 1499 P35222 CTNNB1 human Y654 447585 RNEGVAtyAAAVLFR X +ERBB2 HER2 P04626 human HER2 2064 P04626 ERBB2 human Y1112 448674 DPsPLQRySEDPTVP X +ERBB2 HER2 P04626 human HER2 2064 P04626 ERBB2 human Y1221 449744 sPAFDNLyyWDQDPP X 2243; 2249; 91415 +ERBB2 HER2 P04626 human HER2 2064 P04626 ERBB2 human Y1248 447614 PtAENPEyLGLDVPV X X 2244; 2247 +ERBB2 HER2 P04626 human HER2 2064 P04626 ERBB2 human Y1139 448678 tCsPQPEyVNQPDVR X +ERBB2 HER2 P04626 human CDK1 983 P06493 CDK1 human Y15 447610 EkIGEGtyGVVykGR Pkinase X X 4539; 9111; 14566; 77897 +ERBB2 HER2 P04626 human LDH-A 3939 P00338 LDHA human Y10 454712 tLkDQLIyNLLkEEQ X X +ERBB2 HER2 P04626 human HER2 2064 P04626 ERBB2 human Y1196 448676 GAVENPEyLtPQGGA X 6942 +CDC42BPA MRCKA Q5VT25 human MRCKA 8476 Q5VT25 CDC42BPA human T403 12612503 HLPFVGFtYTSSCVL Pkinase_C X +CDC42BPA MRCKA Q5VT25 human MRCKA 8476 Q5VT25 CDC42BPA human S1003 801662701 RKKGCPGsTGFPPKR X +CDC42BPA MRCKA Q5VT25 human MRCKA 8476 Q5VT25 CDC42BPA human T240 12612501 QsSVAVGtPDYISPE Pkinase X +CDC42BPA MRCKA Q5VT25 human MRLC1 10398 P24844 MYL9 human S20 1863500 KRPQRAtsNVFAMFD X X 3674; 3671; 3675; 95777 +CDC42BPA MRCKA Q5VT25 human MRCKA 8476 Q5VT25 CDC42BPA human S234 12612500 MEDGTVQsSVAVGtP Pkinase X +OXSR1 OSR1 O95747 human NKCC2 6557 Q13621 SLC12A1 human T105 458228 LQtFGHNtMDAVPKI AA_permease_N X +OXSR1 OSR1 O95747 human NKCC1 6558 P55011 SLC12A2 human T207 467236 YYDtHTNtyYLRtFG AA_permease_N X X +OXSR1 OSR1 O95747 human NKCC2 6557 Q13621 SLC12A1 human T118 459122 KIEYYRNtGsISGPK AA_permease_N X +OXSR1 OSR1 O95747 human PAK1 29431 P35465 Pak1 rat T84 450680 LPSDFEHtIHVGFDA PBD X +OXSR1 OSR1 O95747 human Tau iso8 4137 P10636-8 MAPT human S324 449328 kVtskCGsLGNIHHk Tubulin-binding X +OXSR1 OSR1 O95747 human NCCT 6559 P55017 SLC12A3 human T60 469617 MRtFGYNtIDVVPtY AA_permease_N X +OXSR1 OSR1 O95747 human NCCT 6559 P55017 SLC12A3 human S73 469631 tYEHyANstQPGEPR AA_permease_N X +OXSR1 OSR1 O95747 human SMAD3 4088 P84022 SMAD3 human T179 451177 PQSNIPEtPPPGYLS X X +OXSR1 OSR1 O95747 human NKCC1 6558 P55011 SLC12A2 human T212 455545 TNtyYLRtFGHNtMD AA_permease_N X X +OXSR1 OSR1 O95747 human NKCC1 6558 P55011 SLC12A2 human T230 459123 RIDHyRHtAAQLGEk AA_permease_N X +OXSR1 OSR1 O95747 human NKCC1 6558 P55011 SLC12A2 human T203 467235 HQHYYYDtHTNtyYL AA_permease_N X X +OXSR1 OSR1 O95747 human NKCC2 6557 Q13621 SLC12A1 human S120 4708959 EYYRNtGsISGPKVN AA_permease_N X +OXSR1 OSR1 O95747 human NKCC2 6557 Q13621 SLC12A1 human T95 4708938 AYDsHTNtYYLQtFG AA_permease_N X X +OXSR1 OSR1 O95747 human Tau iso8 4137 P10636-8 MAPT human T30 1873559802 RKDQGGytMHQDQEG X +OXSR1 OSR1 O95747 human NKCC2 6557 Q13621 SLC12A1 human T100 458227 TNtYYLQtFGHNtMD AA_permease_N X X +OXSR1 OSR1 O95747 human NCCT 6559 P55017 SLC12A3 human T46 2286406 SSHPSHLtHSStFCM AA_permease_N X +OXSR1 OSR1 O95747 human NCCT 6559 P55017 SLC12A3 human T55 469616 SStFCMRtFGYNtID AA_permease_N X +OXSR1 OSR1 O95747 human SMAD2 4087 Q15796 SMAD2 human T220 448793 QSNYIPEtPPPGYIS X X +OXSR1 OSR1 O95747 human NKCC1 6558 P55011 SLC12A2 human T217 455546 LRtFGHNtMDAVPRI AA_permease_N X +SRC Src P12931 human MST1 58231 Q9JI11 Stk4 mouse Y433 463558 KIPQDGDyEFLKsWT Mst1_SARAH X X +SRC Src P12931 human TRIP6 22051 Q9Z1Y4 Trip6 mouse Y55 456050 PLPPEHCyQPPGVPE X X +SRC Src P12931 human PTEN 5728 P60484 PTEN human Y155 4000973 AQEALDFyGEVRTRD X +SRC Src P12931 human GJA1 2697 P17302 GJA1 human Y265 447815 kDCGsQkyAyFNGCs X X +SRC Src P12931 human SPTAN1 6709 Q13813 SPTAN1 human Y1073 449561 MkQVEELyHsLLELG X +SRC Src P12931 human YAP1 10413 P46937 YAP1 human Y407 473004 sGLsMsSySVPRtPD X +SRC Src P12931 human TIMP2 7077 P16035 TIMP2 human Y90 1257779601 EKDIEFIyTAPSSAV TIMP X X +SRC Src P12931 human APP iso2 11820 P12023-2 App mouse Y653 2061000 VMLkkkQyTsIHHGV APP_amyloid X +SRC Src P12931 human VEGFR3 2324 P35916 FLT4 human Y830 14312600 PLEEQCEyLSyDASQ X +SRC Src P12931 human Trap150 9967 Q9Y2W1 THRAP3 human Y344 480818 AAsGGAAytKRyLEE THRAP3_BCLAF1 X +SRC Src P12931 human CDCP1 64866 Q9H5V8 CDCP1 human Y734 451434 KDNDsHVyAVIEDTM X 9050 +SRC Src P12931 human HNF4 alpha 3172 P41235 HNF4A human Y288 22996303 IDDNEyAyLKAIIFF Hormone_recep X X +SRC Src P12931 human EYA3 2140 Q99504 EYA3 human S138 1870640411 SGLIQTPsPSQHSVL X +SRC Src P12931 human FAK 14083 P34152 Ptk2 mouse Y407 447888 IIDEEDtytMPSTRD X +SRC Src P12931 human Vinculin 396422 P12003 VCL chicken Y100 454004 QMLQADPySVPARDY Vinculin X +SRC Src P12931 human SHC1 iso3 6464 P29353-3 SHC1 human Y194 448509 EEPPDHQyyNDFPGK X +SRC Src P12931 human EYA3 2140 Q99504 EYA3 human Y426 1870640408 YRKVREIyDKHkSNV X +SRC Src P12931 human HDAC3 8841 O15379 HDAC3 human Y331 15228119 PySEyFEyFAPDFTL X X +SRC Src P12931 human KIF11 3832 P52732 KIF11 human Y211 463258 VHNkDEVyQILEkGA Kinesin X X +SRC Src P12931 human GBF1 8729 Q92538 GBF1 human Y516 5516141 VENPKMPyEMKEMAL Sec7_N X +SRC Src P12931 human ATG9A 79065 Q7Z3C6 ATG9A human Y8 62382600 MAQFDTEyQRLEAsy X X +SRC Src P12931 human GTF2I iso2 2969 P78347-2 GTF2I human Y248 448250 EESEDPDyyQyNIQG X +SRC Src P12931 human TRPV1 7442 Q8NER1 TRPV1 human Y200 458384 ASYtDSYyKGQTALH Ank_2 X +SRC Src P12931 human BCKDK 10295 O14874 BCKDK human Y246 1868515109 RRLCEHkyGNAPRVR X X +SRC Src P12931 human PLCG2 5336 P16885 PLCG2 human Y753 447940 ERDINSLyDVsRMyV X +SRC Src P12931 human CDH2 1000 P19022 CDH2 human Y884 450693 SSGGEQDyDyLNDWG CADH_Y-type_LIR X +SRC Src P12931 human BKR2 624 P30411 BDKRB2 human Y347 452100 RKKSWEVyQGVCQKG X +SRC Src P12931 human WNK4 65266 Q96J92 WNK4 human Y1164 40407605 KKEIEDLySRLGKQP X +SRC Src P12931 human GIT1 28964 Q9Y2X7 GIT1 human Y284 15702201 EELAMDVyDEVDRRE GIT_SHD X +SRC Src P12931 human GAB1 2549 Q13480 GAB1 human Y242 455030 FFQQQMIyDsPPSRA X X +SRC Src P12931 human AKAP8 10270 O43823 AKAP8 human Y53 40420004 TTGATySyGPASWEA X +SRC Src P12931 human ARHGAP3 1124 P52757 CHN2 human Y21 482808 VSSDAEEyQPPIWKS X X +SRC Src P12931 human hnRNP K 3190 P61978 HNRNPK human Y234 456002 PNFyDETyDyGGFTM X X +SRC Src P12931 human GluR2 29627 P19491 Gria2 rat Y869 476831 NsQNFATykEGyNVy X 3921 +SRC Src P12931 human ACLY 47 P53396 ACLY human Y682 450360 sRtTDGVyEGVAIGG Ligase_CoA X X +SRC Src P12931 human PSF 6421 P23246 SFPQ human Y691 473374 GPGtPAGyGrGrEEy X +SRC Src P12931 human DVL2 1856 O14641 DVL2 human Y18 12170303 VGEtKVIyHLDEEET DIX X +SRC Src P12931 human GTF2I 2969 P78347 GTF2I human Y248 448250 EESEDPDyyQYNIQA X +SRC Src P12931 human HLAA 3105 P04439 HLA-A human Y344 463579 sDRkGGsytQAAssD MHC_I_C X +SRC Src P12931 human PKCD 170538 P09215 Prkcd rat Y311 447573 TPETVGIyQGFEKKT X X 2055 +SRC Src P12931 human EPS8 2059 Q12929 EPS8 human Y485 450732 EHssVsEyHPADGyA X +SRC Src P12931 human DAPK1 1612 P53355 DAPK1 human Y490 487483 HCAAWHGyySVAKAL Ank_2 X X +SRC Src P12931 human RGS16 6004 O15492 RGS16 human Y177 448653 RFLkSPAyRDLAAQA RGS X +SRC Src P12931 human FAK 14083 P34152 Ptk2 mouse Y576 447889 RyMEDstyyKASKGK PK_Tyr_Ser-Thr X 3281 +SRC Src P12931 human ZC3H4 23211 Q9UPT8 ZC3H4 human Y247 477406 SRGRGRGyRGRGSRG X +SRC Src P12931 human PAG 55824 Q9NWQ8 PAG1 human Y317 450659 EEEIsAMyssVNKPG PAG X +SRC Src P12931 human DDR2 4921 Q16832 DDR2 human Y736 456861 FGMSRNLysGDyyRI PK_Tyr_Ser-Thr X +SRC Src P12931 human NR1H4 9971 Q96RI1 NR1H4 human Y77 1186568001 QISSSSYySNLGFYP X X +SRC Src P12931 human SF3B2 10992 Q13435 SF3B2 human Y379 474329 VtEEPEIyEPNFIFF X +SRC Src P12931 human BCLAF1 9774 Q9NYF8 BCLAF1 human Y80 3804248 YRGrGrGyyQGGGGr X +SRC Src P12931 human PDK1 5170 O15530 PDPK1 human Y376 447695 DEDCyGNyDNLLSQF X X +SRC Src P12931 human FHOD1 29109 Q9Y613 FHOD1 human Y99 31010701 REMLEGFyEEISKGR Formin_GBD_N X +SRC Src P12931 human SHC1 iso3 6464 P29353-3 SHC1 human Y272 448511 ELFDDPSyVNVQNLD X +SRC Src P12931 human UGT2B7 7364 P16662 UGT2B7 human Y438 7378201 RVINDPSyKENVMKL UDPGT X X +SRC Src P12931 human CD163L1 338056 P30205 CD163L1 cow Y1326 470034 DALAEAVyEELDYLL X +SRC Src P12931 human IRTKS 55971 Q9UHR4 BAIAP2L1 human Y156 462515 GsRNALkyEHKEIEy IMD X +SRC Src P12931 human DAG1 13138 Q62165 Dag1 mouse Y890 449630 PyRsPPPyVPP____ DAG1 X 32248 +SRC Src P12931 human EYA3 2140 Q99504 EYA3 human Y77 1869778703 QMySAKPyAHILSVP X X +SRC Src P12931 human GBF1 8729 Q92538 GBF1 human Y1374 1875829506 PsPLINQysLTVGLD X +SRC Src P12931 human GRK2 282682 P21146 GRK2 cow Y92 456873 FyEEIKKyEKLETEE RGS X +SRC Src P12931 human GLRB 2743 P48167 GLRB human Y435 3078004 RDFELSNyDCYGkPI Neur_chan_memb X +SRC Src P12931 human GluR6 2898 Q13002 GRIK2 human Y590 36320701 RFSPYEWyNPHPCNP Lig_chan X +SRC Src P12931 human NCAM-L1 3897 P32004 L1CAM human Y1176 456529 kDEtFGEyRSLEsDN Bravo_FIGEY X +SRC Src P12931 human HRas 3265 P01112 HRAS human Y64 5840738 DTAGQEEySAMRDQY Ras X +SRC Src P12931 human Src iso1 20779 P05480-1 Src mouse Y424 448234 RLIEDNEytARQGAK PK_Tyr_Ser-Thr X 2101; 6943; 59548; 70926; 78740; 94361; 17320 +SRC Src P12931 human NEDD4 iso4 4734 P46934-4 NEDD4 human Y332 3190648 RRGsLQAyTFEEQPT X X +SRC Src P12931 human SHP-1 5777 P29350 PTPN6 human Y564 448912 sKHkEDVyENLHTkN X 8849 +SRC Src P12931 human PARP1 142 P09874 PARP1 human Y992 1875398902 LYNEYIVyDIAQVNL PARP X X +SRC Src P12931 human PKCD 170538 P09215 Prkcd rat Y64 447581 STFDAHIyEGRVIQI X +SRC Src P12931 human FAK 5747 Q05397 PTK2 human Y925 447966 DRsNDkVyENVtGLV Focal_AT X X 3284 +SRC Src P12931 human CDC25A 993 P30304 CDC25A human Y59 57761916 LQGLGSDyEQPLEVK X X +SRC Src P12931 human ephexin-1 53972 Q8CHT1 Ngef mouse Y177 455579 IEQIGLLyQEyRDKS X +SRC Src P12931 human ANXA2 302 P07355 ANXA2 human Y24 449483 HstPPsAyGsVkAyt X +SRC Src P12931 human USP2 9099 O75604 USP2 human S207 803501400 ENYGRKGsASQVPSQ X +SRC Src P12931 human CD46 iso4 4179 P15529-4 CD46 human Y354 451709 kADGGAEyAtyQtkS X +SRC Src P12931 human iNOS 4843 P35228 NOS2 human Y1055 4115776 LPGKPKVyVQDILRQ NAD_binding_1 X +SRC Src P12931 human EFTU 281556 P49410 TUFM cow Y266 464399 LLPVESVySIPGRGT X +SRC Src P12931 human TLR3 7098 O15455 TLR3 human Y759 450187 EQFEYAAyIIHAYKD TIR X X +SRC Src P12931 human ITGB7 3695 P26010 ITGB7 human Y753 469601 YRLSVEIyDRREySR Integrin_b_cyt X +SRC Src P12931 human BCLAF1 9774 Q9NYF8 BCLAF1 human Y408 463073 DtEEtEDyRQFRksV THRAP3_BCLAF1 X +SRC Src P12931 human PTEN 5728 P60484 PTEN human Y174 464091 TIPSQRRyVyyysyL X +SRC Src P12931 human Calmodulin 24242 P0DP29 Calm3 rat Y100 448707 FDkDGNGyIsAAELR EF-hand_7 X +SRC Src P12931 human ROCK2 25537 Q62868 Rock2 rat Y722 464192 LADKNKIyESIEEAK X +SRC Src P12931 human MYH9 4627 P35579 MYH9 human Y158 463834 yAITDTAyRsMMQDr Myosin_head X +SRC Src P12931 human DAB1 13131 P97318 Dab1 mouse Y232 447961 SQKKEGVyDVPKSQP X X 3325 +SRC Src P12931 human EYA3 2140 Q99504 EYA3 human Y508 1870640410 IFPIENIySATKIGk X +SRC Src P12931 human PRKD2 25865 Q9BZL6 PRKD2 human Y87 178601700 kFPECGFyGLYDkIL X X +SRC Src P12931 human PELP1 27043 Q8IZL8 PELP1 human Y920 473548 EEEDEEEyFEEEEEE X +SRC Src P12931 human SRRT 51593 Q9BXP5 SRRT human Y92 7366809 DEHSSDPyHSGYEMP X +SRC Src P12931 human AGO2 27161 Q9UKV8 AGO2 human Y529 17533104 LPGKtPVyAEVkRVG Piwi X +SRC Src P12931 human FAM82A2 55177 Q96TC7 RMDN3 human Y176 19009800 DAESEGGytTANAEs X +SRC Src P12931 human ENG 2022 P17813 ENG human Y612 34729906 LLTAALWyIySHTRS X +SRC Src P12931 human EYA3 2140 Q99504 EYA3 human Y90 1870640403 VPVSETAyPGQTQyQ X X +SRC Src P12931 human GJA1 24392 P08050 Gja1 rat Y265 447815 kDCGsPkyAyFNGCS X X +SRC Src P12931 human CDH1 999 P12830 CDH1 human Y754 456025 DtRDNVyyyDEEGGG X +SRC Src P12931 human SPTAN1 6709 Q13813 SPTAN1 human Y1176 448817 AVQQQEVyGMMPRDE X +SRC Src P12931 human STAP2 55620 Q9UGK3 STAP2 human Y250 478353 PFLLDEDyEKVLGyV X +SRC Src P12931 human FCRL3 115352 Q96P31 FCRL3 human Y722 460222 EEDDEENyENVPRVL X +SRC Src P12931 human Ack 10188 Q07912 TNK2 human Y860 448884 KVsstHyyLLPERPs X +SRC Src P12931 human hnRNP K 3190 P61978 HNRNPK human Y230 456001 QPyDPNFyDETyDyG X X +SRC Src P12931 human CRIK 12704 P49025 Cit mouse Y1237 477284 TERSDLEyQLENIQV X +SRC Src P12931 human PIP5K1C 18717 O70161 Pip5k1c mouse Y644 450241 TDERSWVysPLHYSA X X +SRC Src P12931 human FCRL3 115352 Q96P31 FCRL3 human Y662 469981 PGDSNPIySQIWSIQ X +SRC Src P12931 human IRTKS 55971 Q9UHR4 BAIAP2L1 human Y439 462517 VVIPPPDyLECLsMG X +SRC Src P12931 human EYA3 2140 Q99504 EYA3 human Y208 1870640406 TILGQNQyQACYPSS X X +SRC Src P12931 human EGFR 1956 P00533 EGFR human Y764 465445 kEILDEAyVMAsVDN PK_Tyr_Ser-Thr X +SRC Src P12931 human PLSCR1 5359 O15162 PLSCR1 human Y69 2915403 PVPNQPVyNQPVyNQ X +SRC Src P12931 human PLK1 18817 Q07832 Plk1 mouse Y445 54066601 DSTRLILyNDGDSLQ POLO_box X +SRC Src P12931 human EYA3 2140 Q99504 EYA3 human S157 1870640413 GLTTSQPsPAHYSYP X +SRC Src P12931 human ZDHHC3 69035 Q8R173 Zdhhc3 mouse Y297 56580000 GKADPyQyVV_____ X +SRC Src P12931 human HLAB 3106 P01889 HLA-B human Y344 463580 SGGkGGsySQAACsD MHC_I_C X +SRC Src P12931 human FMIP 8563 Q13769 THOC5 human Y225 25802102 EIEVKKEyLSSLQPR FmiP_Thoc5 X +SRC Src P12931 human CDH2 1000 P19022 CDH2 human Y886 458306 GGEQDyDyLNDWGPR CADH_Y-type_LIR X +SRC Src P12931 human ANXA1 301 P04083 ANXA1 human Y21 447974 IENEEQEyVQtVkss X +SRC Src P12931 human BCLAF1 9774 Q9NYF8 BCLAF1 human Y81 4196063 RGrGrGyyQGGGGry X +SRC Src P12931 human PPP2CA 5515 P67775 PPP2CA human Y127 4251175 SRQITQVyGFYDECL Metallophos X +SRC Src P12931 human TLR2 24088 Q9QUN7 Tlr2 mouse Y647 1876860404 CYDAFVSySEQDSHW TIR X +SRC Src P12931 human CASP8 841 Q14790 CASP8 human Y380 460647 tDsEEQPyLEMDLSs Peptidase_C14 X X +SRC Src P12931 human ROMK 3758 P48048 KCNJ1 human Y337 451246 SKTKEGKyRVDFHNF IRK_C X X +SRC Src P12931 human NRas 4893 P01111 NRAS human Y32 15228782 QNHFVDEyDPTIEDs Ras X X +SRC Src P12931 human NCKIPSD 51517 Q9NZQ3 NCKIPSD human Y227 27528602 STSLDTLyTSSSPSE X +SRC Src P12931 human syntenin 6386 O00560 SDCBP human Y46 455029 IPHDGNLyPRLyPEL X +SRC Src P12931 human Cortactin 13043 Q60598 Cttn mouse Y421 447702 RPPssPIyEDAAPFK X X 4569 +SRC Src P12931 human FBX5 26271 Q9UKT4 FBXO5 human Y142 15339200 ALETSRLyEDsGYSs X X +SRC Src P12931 human HSP90B 3326 P08238 HSP90AB1 human Y301 462282 DDItQEEyGEFyksL HSP90 X X +SRC Src P12931 human WBP2 23558 Q969T9 WBP2 human Y231 464521 AEAAASAyyNPGNPH X +SRC Src P12931 human USP2 9099 O75604 USP2 human S225 803501401 SRVPEIIsPTYRPIG X +SRC Src P12931 human BKR2 624 P30411 BDKRB2 human Y177 457134 GVRWAKLysLVIWGC TM; 7tm_1 X +SRC Src P12931 human Cortactin 2017 Q14247 CTTN human Y470 447703 AyATEAVyESAEAPG X X +SRC Src P12931 human ARAF 369 P10398 ARAF human Y302 455522 GyRDsGyyWEVPPSE X +SRC Src P12931 human DAPK1 1612 P53355 DAPK1 human Y491 487484 CAAWHGyySVAKALC Ank_2 X X +SRC Src P12931 human GABRG2 14406 P22723 Gabrg2 mouse Y413 455818 ERDEEyGyECLDGKD Neur_chan_memb X +SRC Src P12931 human TRIP10 iso3 9322 Q15642-3 TRIP10 human Y471 480709 ESQDTPIyTEFDEDF X +SRC Src P12931 human EYA3 2140 Q99504 EYA3 human Y96 1869778704 AyPGQTQyQTLQQTQ X +SRC Src P12931 human GBF1 8729 Q92538 GBF1 human Y378 4736339 AsVHDMDyVNPRGVR X +SRC Src P12931 human Lmr1 iso2 11302 Q80YE4-2 Aatk mouse Y46 4269100 AQTGPDVyVLPLTEV X +SRC Src P12931 human KIF11 3832 P52732 KIF11 human Y231 14567513 AAtLMNAyssRSHSV Kinesin X X +SRC Src P12931 human BCLAF1 9774 Q9NYF8 BCLAF1 human Y150 7326502 SSRSSsPysksPVsK THRAP3_BCLAF1 X +SRC Src P12931 human RhoGDI alpha 396 P52565 ARHGDIA human Y27 459526 EDEHsVNykPPAQKs Rho_GDI X +SRC Src P12931 human YAP1 iso3 10413 P46937-3 YAP1 human Y341 15565111 PFLNSGTyHSRDEST X X +SRC Src P12931 human HSP90A 3320 P07900 HSP90AA1 human Y197 459268 LkEDQtEyLEErRIk HSP90 X +SRC Src P12931 human FHIT 2272 P49789 FHIT human Y114 447802 FHRNDsIyEELQKHD X X +SRC Src P12931 human ATG9A 79065 Q7Z3C6 ATG9A human Y15 15229023 yQRLEAsysDsPPGE X +SRC Src P12931 human CTNND1 12388 P30999 Ctnnd1 mouse Y228 449648 yPGGsDNyGsLsRVT X X 2911 +SRC Src P12931 human SIRT2 22933 Q8IXJ6 SIRT2 human Y104 479395 RSPStGLyDNLEKYH SIR2 X +SRC Src P12931 human LPIN1 23175 Q14693 LPIN1 human Y795 1871177712 FPNTEPFyAAFGNRP LNS2 X +SRC Src P12931 human SERT 6532 P31645 SLC6A4 human Y47 21697923 SGQISNGysAVPSPG 5HT_transport_N X +SRC Src P12931 human FCRL3 115352 Q96P31 FCRL3 human Y692 469982 HEELTVLySELKKTH X +SRC Src P12931 human Calmodulin 24242 P0DP29 Calm3 rat Y139 448708 DGDGQVNyEEFVQMM EF-hand_7 X +SRC Src P12931 human TrkB 25054 Q63604 Ntrk2 rat Y706 448812 DVyStDyyRVGGHTM PK_Tyr_Ser-Thr X 4621 +SRC Src P12931 human FXN 2395 Q16595 FXN human Y118 41196502 EDLADKPyTFEDYDV Frataxin_Cyay X +SRC Src P12931 human ARAP3 106952 Q8R5G7 Arap3 mouse Y1399 454957 DELEEPVyEEPVyEE X X +SRC Src P12931 human SHC1 6464 P29353 SHC1 human Y350 448510 EPPDHQyyNDFPGKE X X 2434 +SRC Src P12931 human G6PD 2539 P11413 G6PD human Y428 7705803 DLtyGNRyKNVkLPD G6PD_C X +SRC Src P12931 human PKCD 5580 Q05655 PRKCD human Y313 447573 ssEPVGIyQGFEKkT X 2055 +SRC Src P12931 human FAK 5747 Q05397 PTK2 human Y577 447890 yMEDstyyKAsKGKL PK_Tyr_Ser-Thr X 3281 +SRC Src P12931 human STAT5A 6776 P42229 STAT5A human Y694 447767 LAkAVDGyVkPQIkQ X X 9365; 9356; 9359; 9351; 4322; 9314; 3939; 40284; 5387; 14603; 66740; 51879; 72712 +SRC Src P12931 human BCLAF1 9774 Q9NYF8 BCLAF1 human Y93 3803712 GryHrGGyrPVWNRR X +SRC Src P12931 human profilin 1 5216 P07737 PFN1 human Y129 450514 GLINkkCyEMAsHLR Profilin X +SRC Src P12931 human SRRT 51593 Q9BXP5 SRRT human Y798 7366808 tPQGLMPyGQPRPPI ARS2 X +SRC Src P12931 human kindlin-2 10979 Q96AC1 FERMT2 human Y193 6153405 skTMTPtyDAHDGsP X +SRC Src P12931 human PKCD 5580 Q05655 PRKCD human Y334 450077 MQDNsGtyGkIWEGs X +SRC Src P12931 human TUBB3 10381 Q13509 TUBB3 human Y340 464858 IQskNssyFVEWIPN Tubulin_C X +SRC Src P12931 human FBP1 8880 Q96AE4 FUBP1 human Y268 7326500 FREVRNEyGsRIGGN X +SRC Src P12931 human CASP9 842 P55211 CASP9 human Y251 1147026600 LQFPGAVyGTDGCPV Peptidase_C14 X +SRC Src P12931 human PZR 9019 O95297 MPZL1 human Y263 449521 NksEsVVyADIRKN_ X 8088; 5543 +SRC Src P12931 human RBM10 iso2 8241 P98175-2 RBM10 human Y434 473480 SEEPPVDySYYQQDE X +SRC Src P12931 human hnRNP K 3190 P61978 HNRNPK human Y236 456003 FyDETyDyGGFTMMF X X +SRC Src P12931 human Trap150 9967 Q9Y2W1 THRAP3 human Y68 4929715 ErNHPrVyQNrDFrG X +SRC Src P12931 human CD93 22918 Q9NPY3 CD93 human Y644 463128 sRAMENQySPTPGTD X +SRC Src P12931 human ZC3H4 23211 Q9UPT8 ZC3H4 human Y1218 7366812 PTDRYNSyNRPRPKA X +SRC Src P12931 human PLCG1 25738 P10686 Plcg1 rat Y1253 448576 EGsFEARyQQPFEDF X +SRC Src P12931 human DOK1 1796 Q99704 DOK1 human Y362 448367 DPKEDPIyDEPEGLA X +SRC Src P12931 human PKCI 84006 F1M7Y5 Prkci rat Y265 450076 RVIGRGSyAKVLLVR Pkinase X X +SRC Src P12931 human MOR-1 18390 P42866 Oprm1 mouse Y336 5397200 SCLNPVLyAFLDENF 7tm_1 X +SRC Src P12931 human EPS8 2059 Q12929 EPS8 human Y774 457814 CPEGARVysQITVQk SAM_3 X +SRC Src P12931 human P70S6KB 6199 Q9UBS0 RPS6KB2 human Y45 465551 GLEPVGHyEEVELTE X X +SRC Src P12931 human AMPKA2 5563 P54646 PRKAA2 human Y179 11150878 tsCGsPNyAAPEVIS Pkinase X X +SRC Src P12931 human RAPGEF1 2889 Q13905 RAPGEF1 human Y504 448393 APIPSVPyAPFAAIL X +SRC Src P12931 human AP2B1 163 P63010 AP2B1 human Y737 450538 THRQGHIyMEMNFTN Alpha_adaptinC2 X X +SRC Src P12931 human PLK1 18817 Q07832 Plk1 mouse Y166 54066600 QIVLGCQyLHRNQVI Pkinase X +SRC Src P12931 human Villin 7429 P09327 VIL1 human Y256 454007 LKAALKLyHVsDsEG X +SRC Src P12931 human EYA3 2140 Q99504 EYA3 human S438 10941701 SNVGGLLsPQRKEAL X +SRC Src P12931 human WBP2 23558 Q969T9 WBP2 human Y192 20612405 MMDGAMGyVQPPPPP X +SRC Src P12931 human NEDD4 iso4 4734 P46934-4 NEDD4 human Y43 458526 ILGASDPyVRVTLYD C2 X X +SRC Src P12931 human CACNA1C 24239 P22002 Cacna1c rat Y2148 450658 PEDESCVyALGRGRS X X +SRC Src P12931 human LPIN1 23175 Q14693 LPIN1 human Y413 1871177711 DPEVAALyFPKNGDP X +SRC Src P12931 human PTPRJ 5795 Q12913 PTPRJ human Y1320 15228667 NtTAMtIyENLAPVT X X +SRC Src P12931 human p73 7161 O15350 TP73 human Y28 482867 SLEPDStyFDLPQSS X +SRC Src P12931 human FAK 5747 Q05397 PTK2 human Y1007 2867002 kMKLAQQyVMTSLQQ Focal_AT X +SRC Src P12931 human PTEN 5728 P60484 PTEN human Y46 3444123 AERLEGVyRNNIDDV X +SRC Src P12931 human HCN2 15166 O88703 Hcn2 mouse Y476 457528 FRQkIHDyYEHRYQG X +SRC Src P12931 human GSK3B 2932 P49841 GSK3B human Y216 448569 RGEPNVsyICsRyyR Pkinase X +SRC Src P12931 human lamin A/C 4000 P02545 LMNA human Y45 55369404 LNDrLAVyIDrVRsL Filament X X +SRC Src P12931 human DVL2 1856 O14641 DVL2 human Y275 12170305 VTLNMEKyNFLGISI PDZ X +SRC Src P12931 human ZAP70 7535 P43403 ZAP70 human Y319 447587 tsVyEsPysDPEELk X 2701; 2717; 14791; 73382; 82975; 31754 +SRC Src P12931 human APP iso2 11820 P12023-2 App mouse Y687 450343 NGyENPTykFFEQMQ APP_amyloid X +SRC Src P12931 human HK2 3099 P52789 HK2 human Y686 62906106 GTGSNACyMEEMRNV Hexokinase_2 X X +SRC Src P12931 human CDH1 999 P12830 CDH1 human Y797 6158370 tLMsVPRyLPRPANP X +SRC Src P12931 human EGFR 1956 P00533 EGFR human Y1092 448057 tFLPVPEyINQsVPk X 2236; 2234; 3777; 14565; 8543; 48576 +SRC Src P12931 human CACNA1C 775 Q13936 CACNA1C human Y2217 1043301 ELQDSRVyVSSL___ X +SRC Src P12931 human CTNNB1 12387 Q02248 Ctnnb1 mouse Y654 447585 RNEGVATyAAAVLFR X +SRC Src P12931 human TRPV4 63873 Q9EPK8 Trpv4 mouse Y110 4777176 PMDSLFDyGTYRHHP X +SRC Src P12931 human GRB2 14784 Q60631 Grb2 mouse Y160 452038 QMPQQPTyVQALFDF X +SRC Src P12931 human CTNND1 12388 P30999 Ctnnd1 mouse Y217 449647 PDGYGRHyEDGyPGG X +SRC Src P12931 human PTPRJ 5795 Q12913 PTPRJ human Y1311 473909 DSkVDLIyQNtTAMt X X +SRC Src P12931 human Ets-1 2113 P14921 ETS1 human Y283 449428 sLQRVPsyDsFDsED Ets1_N_flank X +SRC Src P12931 human ARAP3 106952 Q8R5G7 Arap3 mouse Y1404 454958 PVyEEPVyEEVGAFP X X +SRC Src P12931 human DGKA 1606 P23743 DGKA human Y335 486452 ILPPSSIyPSVLASG X X +SRC Src P12931 human Cortactin 2017 Q14247 CTTN human Y334 450862 VTQVssAyQktVPVE X +SRC Src P12931 human FLOT1 10211 O75955 FLOT1 human Y56 35494100 NVkSEkVyTRHGVPI Band_7 X +SRC Src P12931 human MDM2 4193 Q00987 MDM2 human Y281 4251185 EVyQVtVyQAGEsDt X +SRC Src P12931 human PRKD1 5587 Q15139 PRKD1 human Y502 449056 TTANVVYyVGENVVN PH X +SRC Src P12931 human GluR2 29627 P19491 Gria2 rat Y873 35547400 FATykEGyNVyGIEs X +SRC Src P12931 human UNC5C 22253 O08747 Unc5c mouse Y568 12563302 QGRVYEMyVTVHRKE ZU5 X +SRC Src P12931 human GAB1 2549 Q13480 GAB1 human Y373 447945 AsDtDssyCIPTAGM X X +SRC Src P12931 human ZC3H4 23211 Q9UPT8 ZC3H4 human Y158 3425765 GHRKyREysPPyAPs X +SRC Src P12931 human VEGFR3 2324 P35916 FLT4 human Y1063 473000 FGLARDIykDPDyVR PK_Tyr_Ser-Thr X X +SRC Src P12931 human SHC3 iso2 53358 Q92529-2 SHC3 human Y218 451254 GDGSDHPyyNSIPSK X +SRC Src P12931 human AKAP8 10270 O43823 AKAP8 human Y154 476956 RPsySyDyEFDLGSD X +SRC Src P12931 human SF3B2 10992 Q13435 SF3B2 human Y592 3457796 TIHGDLyyEGKEFET DUF382 X +SRC Src P12931 human NEDD4 iso4 4734 P46934-4 NEDD4 human Y647 36436801 RVAGMAVyHGKLLDG HECT X X +SRC Src P12931 human SHC1 6464 P29353 SHC1 human Y349 448509 EEPPDHQyyNDFPGK X X 2434 +SRC Src P12931 human ELMO1 9844 Q92556 ELMO1 human Y724 455566 PsNyDFVyDCN____ X +SRC Src P12931 human PPAR-gamma 19016 P37238 Pparg mouse Y78 36692605 SSISAPHyEDIPFTR PPARgamma_N X X +SRC Src P12931 human emerin 2010 P50402 EMD human Y74 451787 tRGDADMyDLPkkED X X +SRC Src P12931 human TGFBR2 7048 P37173 TGFBR2 human Y284 479864 KIFPYEEyASWKTEk PK_Tyr_Ser-Thr X +SRC Src P12931 human CDH2 1000 P19022 CDH2 human Y852 450692 NDPTAPPyDSLLVFD CADH_Y-type_LIR X +SRC Src P12931 human Villin 7429 P09327 VIL1 human Y60 454005 KTASSLSyDIHyWIG Gelsolin X +SRC Src P12931 human GRK2 156 P25098 GRK2 human Y86 447727 ARPLVEFyEEIKKyE RGS X +SRC Src P12931 human NOXA1 10811 Q86UR1 NOXA1 human Y110 17303900 RGHAAIDyTQLGLRF X X +SRC Src P12931 human p27Kip1 1027 P46527 CDKN1B human Y88 456818 kGsLPEFyyRPPRPP X X +SRC Src P12931 human CTNNB1 1499 P35222 CTNNB1 human Y86 447584 VADIDGQyAMTRAQR X +SRC Src P12931 human G6PD 2539 P11413 G6PD human Y249 462295 GTEGRGGyFDEFGII G6PD_C X X +SRC Src P12931 human NMDAR2A 2903 Q12879 GRIN2A human Y1267 461052 PATGEQVyQQDWAQN NMDAR2_C X +SRC Src P12931 human HIPK2 28996 Q9H2X6 HIPK2 human Y361 449571 SkAVCstyLQsRYyR Pkinase X +SRC Src P12931 human HDAC3 8841 O15379 HDAC3 human Y325 1267669100 AISEELPySEyFEyF X +SRC Src P12931 human plakophilin 3 11187 Q9Y446 PKP3 human Y195 451533 PGGLDDRysLVsEQL X X +SRC Src P12931 human RIPK1 8737 Q13546 RIPK1 human Y384 451864 kLQDEANyHLyGsRM X +SRC Src P12931 human AFAP 60312 Q8N556 AFAP1 human Y93 3891000 TSSLPEGyyEEAVPL X +SRC Src P12931 human SDHA 6389 P31040 SDHA human Y215 25682901 SLRYDTSyFVEYFAL FAD_binding_2 X X +SRC Src P12931 human TERT 7015 O14746 TERT human Y707 450084 QDPPPELyFVKVDVT X +SRC Src P12931 human DOK1 13448 P97465 Dok1 mouse Y146 455786 EMLENSLySPTWEGS X +SRC Src P12931 human TRPV6 114246 Q9R186 Trpv6 rat Y201 473577 YRPHNLIyyGEHPLS X +SRC Src P12931 human AKAP8 10270 O43823 AKAP8 human Y539 40420000 IVkMLEkyLKGEDPF AKAP95 X +SRC Src P12931 human SHC3 iso2 53358 Q92529-2 SHC3 human Y256 451255 FAGKEQTyyQGRHLG X +SRC Src P12931 human GIT1 28964 Q9Y2X7 GIT1 human Y321 15702200 FLPVNPEySATRNQG X +SRC Src P12931 human VEGFR3 2324 P35916 FLT4 human Y1333 2874408 ARGGQVFyNSEyGEL X +SRC Src P12931 human PTEN 5728 P60484 PTEN human Y240 448316 RREDKFMyFEFPQPL PTEN_C2 X X +SRC Src P12931 human iNOS 4843 P35228 NOS2 human Y151 457593 IEFVNQYyGSFKEAK NO_synthase X X +SRC Src P12931 human RSK2 6197 P51812 RPS6KA3 human Y483 464202 IItLkDVyDDGKyVY Pkinase X +SRC Src P12931 human EFTU 281556 P49410 TUFM cow Y357 55372823 QKVEAQVyILTKEEG GTP_EFTU_D3 X +SRC Src P12931 human smMLCK 4638 Q15746 MYLK human Y464 451414 QEGsIEVyEDAGsHy I-set X +SRC Src P12931 human PPP2CA 5515 P67775 PPP2CA human Y307 448571 VTRRtPDyFl_____ X X +SRC Src P12931 human RAF1 5894 P04049 RAF1 human Y341 447750 GQRDssyyWEIEASE X X +SRC Src P12931 human SNCA 6622 P37840 SNCA human Y125 448279 VDPDNEAyEMPsEEG Synuclein X +SRC Src P12931 human coronin 7 79585 P57737 CORO7 human Y758 2853108 GDTRVFLyELLPEsP X X +SRC Src P12931 human EYA3 2140 Q99504 EYA3 human Y108 1870640402 QTQPyAVyPQATQTy X X +SRC Src P12931 human FAK 5747 Q05397 PTK2 human Y898 485796 LSsPADSyNEGVKLQ X +SRC Src P12931 human PAK2 5062 Q13177 PAK2 human S141 448295 tVkQKyLsFtPPEkd X 2606 +SRC Src P12931 human JAM-A 50848 Q9Y624 F11R human Y280 458767 tSsKkVIysQPsARs X X +SRC Src P12931 human FHL1 iso1 2273 Q13642-1 FHL1 human Y149 15410160 FPkGEDFyCVTCHET LIM X +SRC Src P12931 human LPP 4026 Q93052 LPP human Y301 448949 GRyyEGyyAAGPGyG X +SRC Src P12931 human GBF1 8729 Q92538 GBF1 human Y877 1875829500 QDILEDMyHAIKNEE Sec7 X X +SRC Src P12931 human PPP2CA 5515 P67775 PPP2CA human Y284 457325 ELDDTLkySFLQFDP X +SRC Src P12931 human GRF-1 232906 Q91YM2 Arhgap35 mouse Y1105 448941 RNEEENIysVPHDST RhoGAP_pG1_pG2 X +SRC Src P12931 human Ack 10188 Q07912 TNK2 human Y859 448883 KKVsstHyyLLPERP X +SRC Src P12931 human Tks5 14218 O89032 Sh3pxd2a mouse Y619 3736027 ALEEETIyENEGFRP X +SRC Src P12931 human Gelsolin 2934 P06396 GSN human Y651 456962 ALGGkAAyRTsPRLK X +SRC Src P12931 human GBF1 8729 Q92538 GBF1 human Y1568 23109211 VRMQALTyLQRALLV X +SRC Src P12931 human PIP5K1C 23396 O60331 PIP5K1C human Y649 450241 TDERSWVysPLHYSA X X +SRC Src P12931 human NMDAR2A 2903 Q12879 GRIN2A human Y1387 455471 GRCPSDPyKHSLPSQ NMDAR2_C X +SRC Src P12931 human p27Kip1 1027 P46527 CDKN1B human Y74 475060 HkPLEGkyEWQEVEk CDI X X +SRC Src P12931 human DYN1 140694 P21575 Dnm1 rat Y597 447606 NTEQRNVykDYRQLE PH X +SRC Src P12931 human SRRT 51593 Q9BXP5 SRRT human Y836 7366807 YGAGrGNyDAFrGQG ARS2 X +SRC Src P12931 human syndecan-2 6383 P34741 SDC2 human Y179 448375 RKkDEGSyDLGErkP Syndecan X +SRC Src P12931 human DUSP12 11266 Q9UNI6 DUSP12 human Y179 1880475700 VDTSSAIyKQYRLQK X X +SRC Src P12931 human VEGFR3 2324 P35916 FLT4 human Y853 14312602 HLGRVLGyGAFGKVV PK_Tyr_Ser-Thr X +SRC Src P12931 human IGF2BP1 395953 O42254 IGF2BP1 chicken Y396 458348 SVSGAAPySSFMPPE X X +SRC Src P12931 human CD93 22918 Q9NPY3 CD93 human Y628 1031156 PQNAADsysWVPERA X +SRC Src P12931 human Cortactin 13043 Q60598 Cttn mouse Y482 447704 yQAEDDTyDGYESDL X X +SRC Src P12931 human Kv1.3 3738 P22001 KCNA3 human Y499 451294 EGEEQSQyMHVGsCQ X +SRC Src P12931 human GBF1 8729 Q92538 GBF1 human Y899 34551124 TGLVRENyVWNVLLH X +SRC Src P12931 human VCP 269523 Q01853 Vcp mouse Y805 449060 EDNDDDLyG______ X X +SRC Src P12931 human SH3PXD2B 285590 A1X283 SH3PXD2B human Y508 17303901 DMSASAGyEEIsDPD X +SRC Src P12931 human IQGAP1 8826 P46940 IQGAP1 human Y1510 450791 LVkLQQtyAALNskA RasGAP_C X X +SRC Src P12931 human WNK4 65266 Q96J92 WNK4 human Y1113 40407606 PSPVWMNySySSLCL X +SRC Src P12931 human CHKA 1119 P35790 CHKA human Y333 21041605 LMLIDFEySSYNYRG Choline_kinase X +SRC Src P12931 human GAB1 2549 Q13480 GAB1 human Y317 449581 PPtPGNtyQIPRTFP X X +SRC Src P12931 human DAAM1 23002 Q9Y4D1 DAAM1 human Y652 7791229 LERTFSAyQRQQDFF FH2 X X +SRC Src P12931 human KLF16 83855 Q9BXK1 KLF16 human Y10 22874704 AAVACVDyFAADVLM X +SRC Src P12931 human STAT3 6774 P40763 STAT3 human Y705 448192 DPGsAAPyLktKFIC X 4093; 9145; 4324; 9131; 9138; 4323; 4074; 4113; 48313; 20977; 25023; 8119; 52075; 52527; 73533; 61958; 73452; 16185; 74309 +SRC Src P12931 human CBL 867 P22681 CBL human Y774 448531 sENEDDGyDVPKPPV X 3555 +SRC Src P12931 human IKKB 3551 O14920 IKBKB human Y188 449632 sFVGTLQyLAPELLE Pkinase X +SRC Src P12931 human FAK 5747 Q05397 PTK2 human Y407 447888 IIDEEDtytMPSTRD X +SRC Src P12931 human p70S6K 83840 P67999 Rps6kb1 rat Y62 465552 DHGGVGPyELGMEHC X +SRC Src P12931 human MDM2 4193 Q00987 MDM2 human Y302 38546303 PEISLADyWKCtsCN zf-RanBP X +SRC Src P12931 human LRP1 4035 Q07954 LRP1 human Y4473 473712 VEIGNPTyKMYEGGE X X +SRC Src P12931 human occludin 100506658 Q16625 OCLN human Y398 5393504 KRtEQDHyEtDyttG X +SRC Src P12931 human ARHGEF2 9181 Q92974 ARHGEF2 human Y198 1869121005 IDEAEVIySELMSDF X +SRC Src P12931 human EGFR 1956 P00533 EGFR human Y1110 448058 GsVQNPVyHNQPLNP X 2220 +SRC Src P12931 human TLR3 364594 Q7TNI8 Tlr3 rat Y760 450187 EQFEYTAyIIHAQKD TIR X +SRC Src P12931 human ACLY 47 P53396 ACLY human Y252 462909 EAyPEEAyIADLDAk Citrate_bind X X +SRC Src P12931 human WWOX 51741 Q9NZC7 WWOX human Y33 449043 TTkDGWVyYANHTEE WW X X +SRC Src P12931 human NPHS1 4868 O60500 NPHS1 human Y1176 2299202 MAFPGHLyDEVERTY X +SRC Src P12931 human NMDAR1 2902 Q05586 GRIN1 human Y837 17613300 LIFIEIAyKRHKDAR CaM_bdg_C0 X +SRC Src P12931 human Gelsolin iso3 2934 P06396-3 GSN human Y438 23109545 GDSYIILyNYRHGGR Gelsolin X +SRC Src P12931 human VEGFR3 2324 P35916 FLT4 human Y1337 2874406 QVFyNSEyGELSEPS X X +SRC Src P12931 human CNK1 10256 Q969H4 CNKSR1 human Y665 33638001 KEQNRELySEGLGAW X +SRC Src P12931 human Ack 10188 Q07912 TNK2 human Y827 448882 SFASDPkyAtPQVIQ Inhibitor_Mig-6 X +SRC Src P12931 human RACK1 10399 P63244 RACK1 human Y246 451481 LCFSPNryWLCAATG WD40 X X +SRC Src P12931 human HNF4 alpha 3172 P41235 HNF4A human Y23 22996301 SAALDPAyTTLEFEN X X +SRC Src P12931 human PEAK1 79834 Q9H792 PEAK1 human Y635 449709 IVINPNAyDNLAIyK X +SRC Src P12931 human Kv2.1 25736 P15387 Kcnb1 rat Y814 22874700 FLRPNCVysSEGLTG X +SRC Src P12931 human DVL2 1856 O14641 DVL2 human Y295 12170306 ERGDGGIyIGSIMkG PDZ X +SRC Src P12931 human p53 7157 P04637 TP53 human Y220 34824801 rHsVVVPyEPPEVGS P53 X X +SRC Src P12931 human coronin 7 79585 P57737 CORO7 human Y288 2853109 GERQLYCyEVVPQQP X +SRC Src P12931 human CTNND2 18163 O35927 Ctnnd2 mouse Y1073 31014801 ERDRQRPySSSRtPs X +SRC Src P12931 human Villin 7429 P09327 VIL1 human Y64 3176603 SLSyDIHyWIGQDSS Gelsolin X +SRC Src P12931 human RHOU 58480 Q7L0Q8 RHOU human Y254 14918203 SkSWWKKyCCFV___ X +SRC Src P12931 human IRTKS 55971 Q9UHR4 BAIAP2L1 human Y163 462516 yEHKEIEyVEtVTSR IMD X +SRC Src P12931 human CDK4 1019 P11802 CDK4 human Y17 455500 AEIGVGAyGTVYkAR Pkinase X +SRC Src P12931 human CD133 8842 O43490 PROM1 human Y828 462569 RMDsEDVyDDVEtIP X X +SRC Src P12931 human CDCP1 64866 Q9H5V8 CDCP1 human Y762 455577 LQPEVDTyRPFQGTM X +SRC Src P12931 human ACLY 47 P53396 ACLY human Y1006 1868989001 PAtPLLDyALEVEkI Citrate_synt X X +SRC Src P12931 human VEGFR2 3791 P35968 KDR human Y1175 447901 AQQDGKDyIVLPISE X 2478; 3770 +SRC Src P12931 human SGEF 622434 D3YYY8 Arhgef26 mouse Y530 479144 TFDPYVKyCTNEVYQ RhoGEF X +SRC Src P12931 human EYA3 2140 Q99504 EYA3 human Y237 1870640400 TTLAATTyQSEKPSV X +SRC Src P12931 human AFAP 60312 Q8N556 AFAP1 human Y125 9691400 MSSSYESyDEEEEDG X +SRC Src P12931 human ARRB1 25387 P29066 Arrb1 rat Y54 458023 yLKERRVyVTLTCAF Arrestin_N X X +SRC Src P12931 human NCKIPSD 51517 Q9NZQ3 NCKIPSD human Y161 454233 LGADGGLyQIPLPSS X +SRC Src P12931 human Abl iso2 25 P00519-2 ABL1 human Y488 450295 EGCPEKVyELMRACW PK_Tyr_Ser-Thr X X +SRC Src P12931 human ataxin-2L 11273 Q8WWM7 ATXN2L human Y744 7366804 VPGQQGKyRGAKGSL X +SRC Src P12931 human RSK2 6197 P51812 RPS6KA3 human Y707 448775 KGAMAAtysALNRNQ X +SRC Src P12931 human occludin Q91049 OCLN chicken Y379 5393504 PELDESQyETDyTTA X +SRC Src P12931 human AKAP8 10270 O43823 AKAP8 human Y146 40420002 CLPEHNPyRPsySyD X +SRC Src P12931 human ARHGAP5 394 Q13017 ARHGAP5 human Y1109 455068 kGysDEIyVVPDDsQ RhoGAP_pG1_pG2 X +SRC Src P12931 human AKAP8 10270 O43823 AKAP8 human Y170 15417596 NGsFGGQySECRDPA X +SRC Src P12931 human girdin 55704 Q3V6T2 CCDC88A human Y1799 450762 QSkDsNPyAtLPRAS X X +SRC Src P12931 human STAP2 55620 Q9UGK3 STAP2 human Y22 11500606 GVLPSHYyESFLEKK PH X +SRC Src P12931 human CNK1 10256 Q969H4 CNKSR1 human Y519 50402001 PPREEDCySETEAED X +SRC Src P12931 human PDHA1 5160 P08559 PDHA1 human Y289 454752 MELQTYRyHGHsMsD E1_dh X +SRC Src P12931 human K19 3880 P08727 KRT19 human Y391 455049 LEGQEDHyNNLsAsk X X +SRC Src P12931 human occludin 100506658 Q16625 OCLN human Y402 458611 QDHyEtDyttGGEsC X +SRC Src P12931 human Kv2.1 3745 Q14721 KCNB1 human Y128 449085 YWGIDEIyLESCCQA BTB_2 X +SRC Src P12931 human 14-3-3 zeta 22631 P63101 Ywhaz mouse Y179 7316700 LNFSVFYyEILNSPE 14-3-3 X +SRC Src P12931 human FAK 5747 Q05397 PTK2 human Y742 6153381 HMVQTNHyQVSGYPG X +SRC Src P12931 human SOCS1 8651 O15524 SOCS1 human Y80 1868450203 LLDACGFyWGPLSVH SH2 X +SRC Src P12931 human RHOA 387 P61586 RHOA human Y34 473955 kDQFPEVyVPTVFEN Ras X +SRC Src P12931 human YAP1 iso3 10413 P46937-3 YAP1 human Y394 54390605 QQNRFPDyLEAIPGT X X +SRC Src P12931 human CYP19A1 1588 P11511 CYP19A1 human Y361 10433800 KVMENFIyESMRYQP p450 X X +SRC Src P12931 human PDK1 5170 O15530 PDPK1 human Y373 447694 sEDDEDCyGNyDNLL X X +SRC Src P12931 human Src 83805 Q9WUD9 Src rat Y419 448234 RLIEDNEyTARQGAk PK_Tyr_Ser-Thr X 2101; 6943; 59548; 70926; 78740; 94361; 17320 +SRC Src P12931 human Kv1.3 3738 P22001 KCNA3 human Y187 451293 FSEEIRFyQLGEEAM BTB_2 X +SRC Src P12931 human CELF2 iso3 29428 Q792H5-3 Celf2 rat Y39 1870336227 LKELFEPyGAVYQIN RRM_1 X X +SRC Src P12931 human Src 6714 P12931 SRC human Y93 4251105 VTTFVALyDyEsRTE SH3_1 X +SRC Src P12931 human PRKD1 5587 Q15139 PRKD1 human Y432 449055 KEGWMVHyTSKDTLR PH X +SRC Src P12931 human Tau iso8 4137 P10636-8 MAPT human Y18 454024 MEDHAGtyGLGDRKD X +SRC Src P12931 human PSD-95 1742 P78352 DLG4 human Y523 4093600 REDSVLSyETVTQME X X +SRC Src P12931 human AGO2 27161 Q9UKV8 AGO2 human Y393 17533102 AsFNtDPyVREFGIM ArgoL2 X X +SRC Src P12931 human GAB1 2549 Q13480 GAB1 human Y259 448877 AsVDssLyNLPRSys X X +SRC Src P12931 human emerin 2010 P50402 EMD human Y95 448938 kGyNDDyyEEsyFtT X X +SRC Src P12931 human GLO1 2739 Q04760 GLO1 human Y136 463450 GIAVPDVysACkRFE Glyoxalase X X +SRC Src P12931 human IRTKS 55971 Q9UHR4 BAIAP2L1 human Y37 21336505 LINLGKNyEkAVNAM IMD X +SRC Src P12931 human DDR2 4921 Q16832 DDR2 human Y740 456862 RNLysGDyyRIQGRA PK_Tyr_Ser-Thr X +SRC Src P12931 human HCRTR1 3061 O43613 HCRTR1 human Y358 2063600 SAANPIIyNFLSGKF 7tm_1; TM X +SRC Src P12931 human FCRL3 115352 Q96P31 FCRL3 human Y650 469980 PMELEPMySNVNPGD X +SRC Src P12931 human SLC25A4 291 P12235 SLC25A4 human Y195 457913 RAAyFGVyDtAkGML TM; Mito_carr X +SRC Src P12931 human IRTKS 55971 Q9UHR4 BAIAP2L1 human Y274 456190 SNVVRKDyDtLskCs X +SRC Src P12931 human TrkB 25054 Q63604 Ntrk2 rat Y705 448811 RDVyStDyyRVGGHT PK_Tyr_Ser-Thr X 4621 +SRC Src P12931 human CASP8 iso4 841 Q14790-4 CASP8 human Y397 460647 TDSEEQPyLEMDLSS Peptidase_C14 X +SRC Src P12931 human CSF2RB 12983 P26955 Csf2rb mouse Y595 450103 SFDFNGPyLGPPQSH X +SRC Src P12931 human PTEN 5728 P60484 PTEN human Y377 4695748 sDNEPDHyRYsDttD X +SRC Src P12931 human GAPDH 2597 P04406 GAPDH human Y42 450511 DPFIDLNyMVyMFQy Gp_dh_N X X +SRC Src P12931 human HRas 3265 P01112 HRAS human Y96 35524900 SFEDIHQyREQIKRV Ras X +SRC Src P12931 human Gelsolin 2934 P06396 GSN human Y465 456958 VPVDPATyGQFYGGD Gelsolin X +SRC Src P12931 human GRK2 156 P25098 GRK2 human Y13 456872 AVLADVSyLMAMEkS X +SRC Src P12931 human NMDAR2A 2903 Q12879 GRIN2A human Y1325 458211 RLLEGNFyGSLFSVP NMDAR2_C X X +SRC Src P12931 human STAT3 6774 P40763 STAT3 human Y68 904653401 LGEIDQQySRFLQES STAT_int X +SRC Src P12931 human CDCP1 64866 Q9H5V8 CDCP1 human Y743 455578 VIEDTMVyGHLLQDS X 14965 +SRC Src P12931 human SERT 6532 P31645 SLC6A4 human Y142 21697922 MELALGQyHRNGCIs SNF X +SRC Src P12931 human iNOS 18126 P29477 Nos2 mouse Y1049 4115776 LPGKPKVyVQDILQK NAD_binding_1 X +SRC Src P12931 human AR 11835 P19091 Ar mouse Y531 1243001 DHVLPIDyYFPPQKT X +SRC Src P12931 human EYA3 2140 Q99504 EYA3 human S225 1870640412 GVTGQTNsDAESTTL X +SRC Src P12931 human HDAC3 8841 O15379 HDAC3 human Y328 1267669101 EELPySEyFEyFAPD X X +SRC Src P12931 human TLR3 142980 Q99MB1 Tlr3 mouse Y760 450187 EQFEYTAyIIHAHkD TIR X +SRC Src P12931 human CDK1 396252 P13863 CDK1 chicken Y15 447610 EKIGEGtyGVVYKGR Pkinase X +SRC Src P12931 human caveolin-1 857 Q03135 CAV1 human Y14 448422 VDsEGHLytVPIREQ X X 3251 +SRC Src P12931 human CHKA 1119 P35790 CHKA human Y197 21041606 RSLGPkLyGIFPQGR Choline_kinase X +SRC Src P12931 human MUC1 4582 P15941 MUC1 human Y1229 448462 sstDRsPyEKVsAGN X +SRC Src P12931 human Alix 10015 Q8WUM4 PDCD6IP human Y319 457636 KkDNDFIyHDrVPDL BRO1 X +SRC Src P12931 human SHC1 6464 P29353 SHC1 human Y427 448511 ELFDDPsyVNVQNLD X 2431 +SRC Src P12931 human CCR7 1236 P32248 CCR7 human Y155 53340200 LCIsIDRyVAIVQAV 7tm_1 X +SRC Src P12931 human DAB1 13131 P97318 Dab1 mouse Y198 447629 EDVEDPVyQyIVFEA X X +SRC Src P12931 human KHSRP 8570 Q92945 KHSRP human Y583 7326501 WAAYYSHyYQQPPGP X +SRC Src P12931 human ITGB7 3695 P26010 ITGB7 human Y758 469602 EIyDRREySRFEkEQ Integrin_b_cyt X +SRC Src P12931 human PKHF1 72287 Q3TB82 Plekhf1 mouse Y208 1868624702 LRVCSLCyRELAAQK FYVE X +SRC Src P12931 human hnRNP K 3190 P61978 HNRNPK human Y458 465997 LQNsVkQySGkFF__ X +SRC Src P12931 human AurA 6790 O14965 AURKA human Y148 457653 kGkFGNVyLAREKQS Pkinase X +SRC Src P12931 human ICAM1 15894 P13597 Icam1 mouse Y518 450460 RQRKIRIyKLQkAQE X +SRC Src P12931 human STING 340061 Q86WV6 STING1 human Y245 1869808400 RVysNSIyELLENGQ TMEM173 X +SRC Src P12931 human TRAF4AF1 90417 Q9Y448 KNSTRN human Y87 3583497 TSVVKtVySLQPPSA X +SRC Src P12931 human Ezrin 7430 P15311 EZR human Y478 454875 PPPPPPVyEPVsyHV X X +SRC Src P12931 human GTF2I 2969 P78347 GTF2I human Y249 459606 ESEDPDyyQYNIQAG X +SRC Src P12931 human PRKD1 5587 Q15139 PRKD1 human Y95 764000 KFPECGFyGMYDKIL X +SRC Src P12931 human ZDHHC3 69035 Q8R173 Zdhhc3 mouse Y295 464577 DQGKADPyQyVV___ X +SRC Src P12931 human LPP 4026 Q93052 LPP human Y244 449712 APssGQIyGsGPQGy X +SRC Src P12931 human TIMP2 7077 P16035 TIMP2 human Y165 1257779600 RCPMIPCyISSPDEC TIMP X X +SRC Src P12931 human DAB1 13131 P97318 Dab1 mouse Y220 447630 PETEENIyQVPTSQK X X 3327 +SRC Src P12931 human SGK223 306506 D3ZMK9 Prag1 rat Y391 449701 AVQPEPIyAESAKRK X +SRC Src P12931 human endophilin B1 51100 Q9Y371 SH3GLB1 human Y80 465105 ARIEEFVyEkLDRKA BAR X X +SRC Src P12931 human AFAP 60312 Q8N556 AFAP1 human Y453 3891002 PEALHyDyIDVEMSA X +SRC Src P12931 human GRB10 2887 Q13322 GRB10 human Y67 448348 NASLESLySACSMQS X X +SRC Src P12931 human PKCI 84006 F1M7Y5 Prkci rat Y280 450075 LKKTDRIyAMKVVKK Pkinase X +SRC Src P12931 human TRIP6 7205 Q15654 TRIP6 human Y55 456050 PLPsEQCyQAPGGPE X X +SRC Src P12931 human EGFR 1956 P00533 EGFR human Y1016 448055 DVVDADEyLIPQQGF X X 2235 +SRC Src P12931 human FAK 14083 P34152 Ptk2 mouse Y577 447890 yMEDstyyKASKGKL PK_Tyr_Ser-Thr X 3281 +SRC Src P12931 human RACK1 10399 P63244 RACK1 human Y52 464119 LtrDEtNyGIPQRAL X +SRC Src P12931 human EPS8 2059 Q12929 EPS8 human Y525 457963 NRHIDRNyEPLKtQP X +SRC Src P12931 human CBL 12402 P22682 Cbl mouse Y737 448530 QQIDSCTyEAMYNIQ X +SRC Src P12931 human PANX1 24145 Q96RD7 PANX1 human Y199 462886 KYPIVEQyLkTkkNS Innexin X X +SRC Src P12931 human FLOT1 10211 O75955 FLOT1 human Y149 35494101 MGISVVSyTLkDIHD Band_7 X +SRC Src P12931 human G6PD 2539 P11413 G6PD human Y507 451668 GFQyEGtykWVNPHk G6PD_C X +SRC Src P12931 human NRF2 4780 Q16236 NFE2L2 human Y576 460703 RDEDGkPysPSEYSL X +SRC Src P12931 human EB1 22919 Q15691 MAPRE1 human Y247 59026901 QRIVDILyATDEGFV EB1 X X +SRC Src P12931 human Src 6714 P12931 SRC human Y530 448235 FTstEPQyQPGENL_ X 2105 +SRC Src P12931 human CDH5 1003 P33151 CDH5 human Y731 456049 PyDTLHIyGyEGSES CADH_Y-type_LIR X +SRC Src P12931 human ELMO1 9844 Q92556 ELMO1 human Y720 455565 IPKEPsNyDFVyDCN X +SRC Src P12931 human AKAP8 10270 O43823 AKAP8 human Y51 40420005 SVTTGATySyGPASW X +SRC Src P12931 human PKCI 84006 F1M7Y5 Prkci rat Y334 450074 RLFFVIEyVNGGDLM Pkinase X +SRC Src P12931 human PKCD 170538 P09215 Prkcd rat Y628 462681 KVKSPSDySNFDPEF Pkinase_C X +SRC Src P12931 human PLCG2 5336 P16885 PLCG2 human Y759 447941 LyDVsRMyVDPsEIN X 3874; 50535 +SRC Src P12931 human RSK2 6197 P51812 RPS6KA3 human Y529 464205 TITKTVEyLHAQGVV Pkinase X X +SRC Src P12931 human EFTU 281556 P49410 TUFM cow Y115 55372798 INAAHVEySTAARHY GTP_EFTU X +SRC Src P12931 human KRas 3845 P01116 KRAS human Y32 15228779 QNHFVDEyDPTIEDs Ras X X +SRC Src P12931 human MYD88 17874 P22366 Myd88 mouse Y58 1876167500 AEEMGFEyLEIRELE Death X +SRC Src P12931 human RACK1 10399 P63244 RACK1 human Y228 450543 LNEGkHLyTLDGGDI WD40 X X +SRC Src P12931 human syntenin 6386 O00560 SDCBP human Y4 23940700 ____MsLyPsLEDLk X +SRC Src P12931 human Cbl-c 23624 Q9ULV8 CBLC human Y341 14913506 SEEQLQLyWAMDSTF X +SRC Src P12931 human NPHS1 4868 O60500 NPHS1 human Y1193 469565 SGAWGPLyDEVQMGP X +SRC Src P12931 human Gelsolin 2934 P06396 GSN human Y409 456960 TDGLGLsyLSSHIAN X +SRC Src P12931 human PSF 6421 P23246 SFPQ human Y597 7366811 RRQREESySRMGyMD X +SRC Src P12931 human TFG 10342 Q92734 TFG human Y33 7366801 IHNEDITyDELVLMM PB1 X +SRC Src P12931 human EYA3 2140 Q99504 EYA3 human Y72 1870640405 NDyTSQMySAKPyAH X X +SRC Src P12931 human GJA1 2697 P17302 GJA1 human Y247 447814 VKGksDPyHAtsGAL X X +SRC Src P12931 human RSK2 6197 P51812 RPS6KA3 human Y580 3455194 GLLMtPCytANFVAP Pkinase X +SRC Src P12931 human Lmr1 iso2 11302 Q80YE4-2 Aatk mouse Y25 4269101 ENAEGDEyVADFSEQ X +SRC Src P12931 human CD133 8842 O43490 PROM1 human Y852 462570 GYHkDHVyGIHNPVM X X +SRC Src P12931 human GTF2I iso2 2969 P78347-2 GTF2I human Y611 448253 KPELVISyLPPGMAS X +SRC Src P12931 human RPT2 19179 P62192 Psmc1 mouse Y439 451910 EGtPEGLyL______ X +SRC Src P12931 human HER2 2064 P04626 ERBB2 human Y877 448694 LDIDEtEyHADGGkV PK_Tyr_Ser-Thr X X 2241 +SRC Src P12931 human DLC1 50768 Q9R0Z9 Dlc1 mouse Y702 1869008601 SAEDNVNyEGQSAYD RhoGAP X X +SRC Src P12931 human NCAM-L1 396059 Q90933 L1CAM chicken Y1186 456529 KDETFGEyRSLESEA Bravo_FIGEY X +SRC Src P12931 human FAK 5747 Q05397 PTK2 human Y397 447887 sVsEtDDyAEIIDEE X X 3283; 8556 +SRC Src P12931 human NMDAR2A 2903 Q12879 GRIN2A human Y1292 4109565 RISRQHsyDNIVDKP NMDAR2_C X +SRC Src P12931 human PAK3 5063 O75914 PAK3 human S154 448123 VNNQKYMsFTSGDKS X 2606 +SRC Src P12931 human CDH2 1000 P19022 CDH2 human Y820 458307 PIHAEPQyPVRsAAP X +SRC Src P12931 human EGFR 1956 P00533 EGFR human Y869 448061 LGAEEkEyHAEGGkV PK_Tyr_Ser-Thr X X 2231; 6963 +SRC Src P12931 human CTNND2 18163 O35927 Ctnnd2 mouse Y1112 473157 LKERKTDyEsAGNNA X +SRC Src P12931 human HK1 3098 P19367 HK1 human Y732 462391 YDrLVDEysLNAGkQ Hexokinase_2 X X +SRC Src P12931 human EGFR 1956 P00533 EGFR human Y727 457949 sGAFGtVykGLWIPE PK_Tyr_Ser-Thr X +SRC Src P12931 human hnRNP K 3190 P61978 HNRNPK human Y380 456004 yAGGrGsyGDLGGPI X X +SRC Src P12931 human Cortactin 2017 Q14247 CTTN human Y486 447704 yPAEDStyDEYENDL X +SRC Src P12931 human G6PD 2539 P11413 G6PD human Y322 4114824 EGEATkGyLDDPTVP G6PD_C X X +SRC Src P12931 human AGO2 27161 Q9UKV8 AGO2 human Y749 13830224 HPTEFDFyLCsHAGI Piwi X +SRC Src P12931 human Gelsolin 2934 P06396 GSN human Y603 456961 LKTPsAAyLWVGTGA Gelsolin X +SRC Src P12931 human FHL1 iso1 2273 Q13642-1 FHL1 human Y272 1015543 VFHQEQVyCPDCAkK LIM X +SRC Src P12931 human AFAP 60312 Q8N556 AFAP1 human Y94 3891001 SSLPEGyyEEAVPLs X +SRC Src P12931 human FAK 5747 Q05397 PTK2 human Y861 447965 PIGNQHIyQPVGKPD X X +SRC Src P12931 human CTNNB1 1499 P35222 CTNNB1 human Y333 471406 NIMRTytyEkLLWTT X X +SRC Src P12931 human Villin 7429 P09327 VIL1 human Y81 454006 EQGAAAIyTTQMDDF Gelsolin X +SRC Src P12931 human DYN1 140694 P21575 Dnm1 rat Y231 447605 LLPLRRGyIGVVNRS Dynamin_M X +SRC Src P12931 human GIT1 28964 Q9Y2X7 GIT1 human Y246 12243296 PDHKNGHyIIPQMAD X +SRC Src P12931 human FLOT2 83764 Q9Z2S9 Flot2 rat Y163 475941 DVyDKVDyLSSLGKT Band_7 X +SRC Src P12931 human PRC1 9055 O43663 PRC1 human Y464 474466 QTETEMLyGsAPRtP MAP65_ASE1 X +SRC Src P12931 human Fos 2353 P01100 FOS human Y30 473044 AGDSLSYyHsPADSF X X +SRC Src P12931 human eNOS 287024 P29473 NOS3 cow Y83 456466 WELGSITyDTLCAQS X X +SRC Src P12931 human Trap150 9967 Q9Y2W1 THRAP3 human Y107 7366806 NrGGYGNyrSNWQNy X +SRC Src P12931 human EFTU 281556 P49410 TUFM cow Y246 474427 LLDAVDTyIPVPTRD GTP_EFTU X +SRC Src P12931 human HCN4 10021 Q9Y3Q4 HCN4 human Y531 1240811 RRQYQEKyKQVEQYM X +SRC Src P12931 human PLD2 5338 O14939 PLD2 human Y511 10036100 FFWLGKDySNLITKD X +SRC Src P12931 human CLCN3 iso2 84360 P51792-2 Clcn3 rat Y284 3577859 FSLEEVSyYFPLKTL Voltage_CLC X +SRC Src P12931 human ATP4A 397552 P19156 ATP4A pig Y7 484289 _MGKAENyELyQVEL H-K_ATPase_N X +SRC Src P12931 human RRas 6237 P10301 RRAS human Y66 448122 DPTIEDSyTKICSVD Ras X +SRC Src P12931 human SLC11A1 6556 P49279 SLC11A1 human Y15 4706965 QRLSGSSyGSISSPT X +SRC Src P12931 human syndecan-4 6385 P31431 SDC4 human Y180 474327 KkKDEGsyDLGKKPI Syndecan X X +SRC Src P12931 human PLCG1 25738 P10686 Plcg1 rat Y783 447667 EGRNPGFyVEANPMP X 2821; 14461; 14008; 25678; 88717 +SRC Src P12931 human PKCD 170538 P09215 Prkcd rat Y332 450077 IPDNNGTyGKIWEGS X +SRC Src P12931 human IRTKS 55971 Q9UHR4 BAIAP2L1 human Y293 472861 PAPSGRAytsPLIDM X +SRC Src P12931 human tensin 3 64759 Q68CZ2 TNS3 human Y1206 9824601 sHsFRGAyGLAMKVA SH2 X X +SRC Src P12931 human YAP1 iso3 10413 P46937-3 YAP1 human Y357 473004 SGLSMSSySVPRtPD X X +SRC Src P12931 human RSK2 6197 P51812 RPS6KA3 human Y470 478835 EIEILLRyGQHPNII Pkinase X +SRC Src P12931 human NDFIP2 54602 Q9NV92 NDFIP2 human Y167 3973278 TTSDTEVyGEFyPVP X +SRC Src P12931 human STAP2 55620 Q9UGK3 STAP2 human Y322 3974222 GDGPAVDyENQDVAS X +SRC Src P12931 human SORBS1 iso5 20411 Q62417-5 Sorbs1 mouse Y326 460519 RAEPKSIyEYQPGKS X +SRC Src P12931 human TFG 10342 Q92734 TFG human Y247 7366802 EGQMYQQyQQQAGYG X +SRC Src P12931 human AKAP8 10270 O43823 AKAP8 human Y152 7366805 PyRPsySyDyEFDLG X X +SRC Src P12931 human SHC1 iso3 6464 P29353-3 SHC1 human Y195 448510 EPPDHQyyNDFPGKE X +SRC Src P12931 human FAK 5747 Q05397 PTK2 human Y441 462051 GDVHQGIyMsPENPA PK_Tyr_Ser-Thr X +SRC Src P12931 human RBM10 iso2 8241 P98175-2 RBM10 human Y905 7326503 LGArGSsyGVTSTES X +SRC Src P12931 human caveolin-2 858 P51636 CAV2 human Y19 450198 LFMDDDsysHHsGLE Caveolin X +SRC Src P12931 human DLC1 50768 Q9R0Z9 Dlc1 mouse Y452 1869008602 NVPGSILySSSGELA X X +SRC Src P12931 human GUCY1B1 2983 Q02153 GUCY1B1 human Y192 469612 ESKEEDFyEDLDRFE X X +SRC Src P12931 human syndecan-4 6385 P31431 SDC4 human Y197 454904 kAPtNEFyA______ X +SRC Src P12931 human CDC42 iso1 998 P60953-1 CDC42 human Y64 450272 DTAGQEDyDRLRPLS Ras X X +SRC Src P12931 human endophilin A2 6455 Q99961 SH3GL1 human Y315 450745 QPSCKALyDFEPEND SH3_1 X X +SRC Src P12931 human RhoGDI beta 397 P52566 ARHGDIB human Y24 448978 ELdskLNykPPPQks Rho_GDI X X +SRC Src P12931 human PANX1 24145 Q96RD7 PANX1 human Y309 54421200 KTDVLkVyEILPTFD X X +SRC Src P12931 human EYA3 2140 Q99504 EYA3 human Y325 1870640414 HSLLTGSyAQKYGKD X +SRC Src P12931 human NELFCD iso4 51497 Q8IXH7-4 NELFCD human Y6 23003806 __MDEDYyGSAAEWG TH1 X X +SRC Src P12931 human calponin 3 1266 Q15417 CNN3 human Y10 6154088 HFNkGPsyGLsAEVK X +SRC Src P12931 human CDH5 1003 P33151 CDH5 human Y685 455658 LDARPsLyAQVQKPP X X +SRC Src P12931 human EWS 2130 Q01844 EWSR1 human Y278 463305 HPSSMGVyGQESGGF X +SRC Src P12931 human AKAP8 10270 O43823 AKAP8 human Y150 15407467 HNPyRPsySyDyEFD X +SRC Src P12931 human EYA3 2140 Q99504 EYA3 human Y67 1870640404 IPRSSNDyTSQMySA X +SRC Src P12931 human NMDAR2A 2903 Q12879 GRIN2A human Y1184 476852 GLsNNDQyKLySKHF NMDAR2_C X +SRC Src P12931 human EPS8 2059 Q12929 EPS8 human Y602 450736 LGRADPPytHtIQKQ X +SRC Src P12931 human Gelsolin 2934 P06396 GSN human Y86 456959 VPVPTNLyGDFFTGD Gelsolin X +SRC Src P12931 human TACE 57027 Q9Z1K9 Adam17 rat Y702 28706300 DKKLDKQyESLSLFH X +SRC Src P12931 human P130Cas 9564 P56945 BCAR1 human Y128 448778 SKAQQGLyQVPGPsP X +SRC Src P12931 human p27Kip1 1027 P46527 CDKN1B human Y89 456819 GsLPEFyyRPPRPPK X X +SRC Src P12931 human EGFR 1956 P00533 EGFR human Y944 463349 PICtIDVyMIMVKCW PK_Tyr_Ser-Thr X X +SRC Src P12931 human G6PD 2539 P11413 G6PD human Y112 455132 NsyVAGQyDDAASYQ G6PD_N X X +SRC Src P12931 human TIMP2 7077 P16035 TIMP2 human Y62 23152807 VDsGNDIyGNPIkRI TIMP X X +SRC Src P12931 human NMDAR2A 2903 Q12879 GRIN2A human Y1423 476854 SRGHNDVyISEHVMP NMDAR2_C X +SRC Src P12931 human EGFR 1956 P00533 EGFR human Y1125 449795 APsRDPHyQDPHstA X +SRC Src P12931 human PBK 55872 Q96KB5 PBK human Y74 473837 NPICNDHyRsVyQkR Pkinase X X +SRC Src P12931 human RhoGDI beta 397 P52566 ARHGDIB human Y153 7386101 yGPRPEEyEFLtPVE Rho_GDI X X +SRC Src P12931 human DVL2 1856 O14641 DVL2 human Y463 12170307 SDVVDWLyHHVEGFP DEP X +SRC Src P12931 human DYN2 1785 P50570 DNM2 human Y597 451200 NtEQRNVykDLRQIE PH X +SRC Src P12931 human SHP-1 5777 P29350 PTPN6 human Y536 448506 QkGQEsEyGNItyPP X X +SRC Src P12931 human ITGB3 3690 P05106 ITGB3 human Y773 448012 DtANNPLyKEAtstF Integrin_b_cyt X +SRC Src P12931 human PLEKHG2 64857 Q9H7P9 PLEKHG2 human Y489 23133014 sEPVKDPyVMFPQNA X +SRC Src P12931 human DMAP1 55929 Q9NPF5 DMAP1 human Y246 998916 EQVAEEEyLLQELRK DMAP1 X X +SRC Src P12931 human TRIM25 7706 Q14258 TRIM25 human Y278 450585 NSkFDtIyQILLkkk X +SRC Src P12931 human SYNJ2 8871 O15056 SYNJ2 human Y490 27166601 LLLVGDVyGEEVADK X +SRC Src P12931 human SYN1 281510 P17599 SYN1 cow Y301 478277 VVALTKTyATTEPFI Synapsin_C X +SRC Src P12931 human CEACAM1 634 P13688 CEACAM1 human Y520 451429 LTATEIIysEVKKQ_ X X +SRC Src P12931 human STAT5B 6777 P51692 STAT5B human Y699 448198 tAkAVDGyVkPQIkQ X 9365; 9356; 9359; 9351; 4322; 9314; 3939; 40284; 5387; 14603; 66740; 51879; 72712 +SRC Src P12931 human RBM10 iso2 8241 P98175-2 RBM10 human Y16 7366800 RGDRTGRyGATDRSQ X +SRC Src P12931 human RAC1 5879 P63000 RAC1 human Y64 475227 DTAGQEDyDRLRPLs Ras X +SRC Src P12931 human RGS16 6004 O15492 RGS16 human Y168 448652 TLMEKDSyPRFLkSP RGS X X +SRC Src P12931 human GRK2 156 P25098 GRK2 human Y92 456873 FyEEIKKyEkLETEE RGS X +SRC Src P12931 human RAF1 5894 P04049 RAF1 human Y340 447749 RGQRDssyyWEIEAS X +SRC Src P12931 human PTEN 5728 P60484 PTEN human Y315 448317 RADNDKEyLVLtLtK PTEN_C2 X +SRC Src P12931 human VAMP7 6845 P51809 VAMP7 human Y45 27806317 SENNKLTySHGNYLF Longin X X +SRC Src P12931 human FAK 5747 Q05397 PTK2 human Y194 18122800 ALEKKSNyEVLEkDV FERM_M X +SRC Src P12931 human MEGF10 84466 Q96KG7 MEGF10 human Y1030 12186245 LSSSENPyATIKDPP X +SRC Src P12931 human CDH5 1003 P33151 CDH5 human Y658 456048 GEMDTTSyDVSVLNs X +SRC Src P12931 human CTNNB1 1499 P35222 CTNNB1 human Y654 447585 RNEGVAtyAAAVLFR X +SRC Src P12931 human Daple 440193 Q9P219 CCDC88C human Y2025 899136400 PQTVWyEyGCV____ X X +SRC Src P12931 human EYA3 2140 Q99504 EYA3 human Y105 1870640401 TLQQTQPyAVyPQAT X X +SRC Src P12931 human ADAM12 11489 Q61824 Adam12 mouse Y901 448371 PRPSHNAyIK_____ X X +SRC Src P12931 human NDUFV2 4729 P19404 NDUFV2 human Y193 25682900 VQINDNYyEDLTAKD 2Fe-2S_thioredx X X +SRC Src P12931 human RhoGDI alpha 396 P52565 ARHGDIA human Y156 469606 YGPRAEEyEFLtPVE Rho_GDI X X +SRC Src P12931 human AKAP8 10270 O43823 AKAP8 human Y80 40420001 PAMHMASyGPEPCTD X +SRC Src P12931 human TRPV4 63873 Q9EPK8 Trpv4 mouse Y805 6097708 DPGKSEIyQYYGFSH X +SRC Src P12931 human CTNND2 18163 O35927 Ctnnd2 mouse Y1176 461085 QEPSRkDyETyQPFP X +SRC Src P12931 human Daple 440193 Q9P219 CCDC88C human Y2023 899136401 GDPQTVWyEyGCV__ X X +SRC Src P12931 human PLSCR1 5359 O15162 PLSCR1 human Y74 464050 PVyNQPVyNQPVGAA X +SRC Src P12931 human CDH2 1000 P19022 CDH2 human Y860 458305 DSLLVFDyEGSGSTA CADH_Y-type_LIR X +SRC Src P12931 human KHSRP 8570 Q92945 KHSRP human Y317 3556400 GFGDrNEyGsRIGGG X +SRC Src P12931 human EFTU 281556 P49410 TUFM cow Y92 38482677 GGAKFKKyEEIDNAP GTP_EFTU X +SRC Src P12931 human Vinculin 396422 P12003 VCL chicken Y1134 454003 WVRKTPWyQ______ X X +SRC Src P12931 human KRas 3845 P01116 KRAS human Y64 5840743 DTAGQEEySAMRDQY Ras X X +SRC Src P12931 human nAChRA7 1139 P36544 CHRNA7 human Y386 457466 ASNGNLLyIGFRGLD Neur_chan_memb X +SRC Src P12931 human ER-alpha 2099 P03372 ESR1 human Y537 448103 CKNVVPLyDLLLEML X +SRC Src P12931 human syndecan-1 6382 P18827 SDC1 human Y286 458494 KkkDEGsysLEEPkQ Syndecan X +SRC Src P12931 human VAV3 10451 Q9UKW4 VAV3 human Y173 455605 EDEGGEVyEDLMKAE X +SRC Src P12931 human RHOA 387 P61586 RHOA human Y66 475231 DtAGQEDyDRLRPLS Ras X +SRC Src P12931 human Ret 5979 P07949 RET human Y905 447627 DVyEEDsyVKRsQGR PK_Tyr_Ser-Thr X 3221 +SRC Src P12931 human PKHF1 72287 Q3TB82 Plekhf1 mouse Y268 1868624701 WPTQVEFyASGVSWS X +SRC Src P12931 human GRF-1 2909 Q9NRY4 ARHGAP35 human Y1087 449570 DGFDPsDyAEPMDAV RhoGAP_pG1_pG2 X +SRC Src P12931 human Trap150 9967 Q9Y2W1 THRAP3 human Y118 6422800 WQNyrQAysPRRGRS X +SRC Src P12931 human TRPV6 114246 Q9R186 Trpv6 rat Y202 473578 RPHNLIyyGEHPLSF X +SRC Src P12931 human GBF1 8729 Q92538 GBF1 human Y317 1875829502 EQPGsPGySTATEPG X +SRC Src P12931 human Cofilin-1 1072 P23528 CFL1 human Y68 449642 GQtVDDPyAtFVkML Cofilin_ADF X X +SRC Src P12931 human AFAP 60312 Q8N556 AFAP1 human Y451 475079 TDPEALHyDyIDVEM X +SRC Src P12931 human Cortactin 13043 Q60598 Cttn mouse Y466 447703 TyTSEPVyETTEAPG X X +SRC Src P12931 human Fos 2353 P01100 FOS human Y10 473043 FSGFNADyEASSSRC X X +SRC Src P12931 human RSK2 6197 P51812 RPS6KA3 human Y644 473285 KFSLSGGyWNSVSDT Pkinase X +SRC Src P12931 human CRIK 12704 P49025 Cit mouse Y1246 57761910 LENIQVLySHEKVKM X +SRC Src P12931 human GJA1 2697 P17302 GJA1 human Y313 454254 sEQNWANysAEQNRM Connexin43 X X +SRC Src P12931 human nAChRA7 1139 P36544 CHRNA7 human Y442 457467 KILEEVRyIANRFRC Neur_chan_memb X +SRC Src P12931 human TAZ 97064 Q9EPK5 Wwtr1 mouse Y316 27138200 sGLGLGCySVPTTPE X +SRC Src P12931 human ATP1A1 476 P05023 ATP1A1 human Y149 54363508 ITGCFSYyQEAKSSk TM X +SRC Src P12931 human PBK 55872 Q96KB5 PBK human Y272 54400800 DFDDEAYyAALGTRP Pkinase X +SRC Src P12931 human ATP1A1 476 P05023 ATP1A1 human Y260 454981 tARGIVVytGDrtVM E1-E2_ATPase X X +SRC Src P12931 human tensin 3 64759 Q68CZ2 TNS3 human Y1173 9824600 QDTSkFWykADISRE SH2 X X +SRC Src P12931 human PKCD 170538 P09215 Prkcd rat Y565 447576 IRVDTPHyPRWITKE Pkinase X +SRC Src P12931 human VEGFR3 2324 P35916 FLT4 human Y833 14312601 EQCEyLSyDASQWEF X +SRC Src P12931 human hnRNP K 3190 P61978 HNRNPK human Y225 456000 IkGRAQPyDPNFyDE X X +SRC Src P12931 human ENG 2022 P17813 ENG human Y614 34729907 TAALWyIySHTRSPS X +SRC Src P12931 human GABRG2 14406 P22723 Gabrg2 mouse Y411 455817 LQERDEEyGyECLDG Neur_chan_memb X +SRC Src P12931 human LPIN1 23175 Q14693 LPIN1 human Y398 1871177710 HLGADGVyLDDLTDM X +SRC Src P12931 human PTTG1IP 754 P53801 PTTG1IP human Y174 454097 LFkEENPyARFENN_ X +SRC Src P12931 human FAK 14083 P34152 Ptk2 mouse Y925 447966 DRSNDKVyENVTGLV Focal_AT X X 3284 +SRC Src P12931 human CAPN2 824 P17655 CAPN2 human Y625 3413522 RSGtMNSyEMRkALE X +SRC Src P12931 human EGFR 1956 P00533 EGFR human Y915 384460500 MTFGSkPyDGIPASE PK_Tyr_Ser-Thr X X +SRC Src P12931 human DDR2 4921 Q16832 DDR2 human Y471 451276 EQGsNstyDrIFPLR X +SRC Src P12931 human NEDD4 iso4 4734 P46934-4 NEDD4 human Y585 4155214 DGEKGLDyGGVAREW X X +SRC Src P12931 human SPRY2 10253 O43597 SPRY2 human Y55 448849 AIRNTNEytEGPTVV X X +SRC Src P12931 human Pyk2 19229 Q9QVP9 Ptk2b mouse Y402 447955 CSIESDIyAEIPDET X 3291 +SRC Src P12931 human Kv2.1 25736 P15387 Kcnb1 rat Y690 22874701 LLPSLGLyHDPLRNR X +SRC Src P12931 human ARHGEF7 iso1 8874 Q14155-1 ARHGEF7 human Y442 3753309 PAPLTPAyHTLPHPS X +SRC Src P12931 human PZR 9019 O95297 MPZL1 human Y241 451272 sHQGPVIyAQLDHsG X 8131 +SRC Src P12931 human Pyk2 2185 Q14289 PTK2B human Y402 447955 CsIEsDIyAEIPDEt X X 3291 +SRC Src P12931 human DVL2 1856 O14641 DVL2 human Y27 12170304 LDEEETPyLVkIPVP DIX X +SRC Src P12931 human PTPRA iso6 5786 P18433-2 PTPRA human Y789 447613 yIDAFSDyANFK___ X 4481 +SRC Src P12931 human FAK 25614 O35346 Ptk2 rat Y397 447887 SVSETDDyAEIIDEE X 3283; 8556 +SRC Src P12931 human AR 367 P10275 AR human Y535 470068 MDSYSGPyGDMRLET X +SRC Src P12931 human AT1 185 P30556 AGTR1 human Y319 448745 YFLQLLKyIPPKAKS X +SRC Src P12931 human GAK 2580 O14976 GAK human Y1149 23108884 CTQPRPNyAsNFsVI X X +SRC Src P12931 human HER2 2064 P04626 ERBB2 human Y1248 447614 PtAENPEyLGLDVPV X 2244; 2247 +SRC Src P12931 human RHOA 11848 Q9QUI0 Rhoa mouse Y42 150180312 VPTVFENyVADIEVD Ras X +SRC Src P12931 human TfR 7037 P02786 TFRC human Y20 448928 FGGEPLsytRFsLAR X +SRC Src P12931 human Kv2.1 25736 P15387 Kcnb1 rat Y128 449085 YWGIDEIyLESCCQA BTB_2 X +SRC Src P12931 human BCLAF1 9774 Q9NYF8 BCLAF1 human Y284 476579 VGNGssRysPsQNsP THRAP3_BCLAF1 X +SRC Src P12931 human GluR2 29627 P19491 Gria2 rat Y876 452173 ykEGyNVyGIEsVkI X 4027; 3921 +SRC Src P12931 human PTEN 5728 P60484 PTEN human Y68 7331394 HKNHYkIyNLCAERH X +SRC Src P12931 human WAVE1 8936 Q92558 WASF1 human Y125 457673 PIPLQETyDVCEQPP X X +SRC Src P12931 human LPP 4026 Q93052 LPP human Y300 448948 QGRyyEGyyAAGPGy X +SRC Src P12931 human ACLY 47 P53396 ACLY human Y227 1868989000 KVDATADyICkVkWG X X +SRC Src P12931 human CDC25A 993 P30304 CDC25A human Y486 57761917 SYCEPPSyRPMHHED X +SRC Src P12931 human GBF1 8729 Q92538 GBF1 human Y1514 1875829510 HTRAASIySSWAEEQ X +SRC Src P12931 human FAK 5747 Q05397 PTK2 human Y576 447889 RyMEDstyyKAsKGK PK_Tyr_Ser-Thr X 3281 +SRC Src P12931 human smMLCK 4638 Q15746 MYLK human Y471 451415 yEDAGsHyLCLLKAR I-set X +SRC Src P12931 human SORBS1 iso5 20411 Q62417-5 Sorbs1 mouse Y360 3782802 SEPPGYIySSNFHAV X +SRC Src P12931 human emerin 2010 P50402 EMD human Y59 463283 sssAAssysFsDLNs X X +SRC Src P12931 human HNF4 alpha 3172 P41235 HNF4A human Y286 22996302 LQIDDNEyAyLKAII Hormone_recep X X +SRC Src P12931 human CDK1 983 P06493 CDK1 human Y15 447610 EkIGEGtyGVVykGR Pkinase X 4539; 9111; 14566; 77897 +SRC Src P12931 human ARAF 369 P10398 ARAF human Y301 455521 LGyRDsGyyWEVPPS X +SRC Src P12931 human girdin 55704 Q3V6T2 CCDC88A human Y1765 450761 PRktEDtyFISSAGk X X +SRC Src P12931 human Src 6714 P12931 SRC human Y338 451705 VVSEEPIyIVTEyMS PK_Tyr_Ser-Thr X +SRC Src P12931 human GRK2 282682 P21146 GRK2 cow Y86 447727 AKPLVEFyEEIKKyE RGS X +SRC Src P12931 human LDH-A 3939 P00338 LDHA human Y10 454712 tLkDQLIyNLLkEEQ X X +SRC Src P12931 human IGF2BP1 303477 Q8CGX0 Igf2bp1 rat Y396 458348 SVTGAAPyGSFMQAP X +SRC Src P12931 human tensin 3 64759 Q68CZ2 TNS3 human Y1256 462739 kGCsNEPyFGsLtAL SH2 X X +SRC Src P12931 human FBP1 8880 Q96AE4 FUBP1 human Y625 473389 yyRQQAAyyAQtsPQ DUF1897 X +SRC Src P12931 human caveolin-1 12389 P49817 Cav1 mouse Y14 448422 VDsEGHLytVPIREQ X 3251 +SRC Src P12931 human calponin 2 1265 Q99439 CNN2 human Y12 6154129 QFNkGPsyGLsAEVk X +SRC Src P12931 human CBL 867 P22681 CBL human Y731 448530 QQIDSCTyEAMyNIQ X 3554 +SRC Src P12931 human CNK1 10256 Q969H4 CNKSR1 human Y26 50402000 LDDsLQDyPFEDWQL SAM_1 X +SRC Src P12931 human Fer 2241 P16591 FER human Y714 448461 RQEDGGVyssSGLkQ PK_Tyr_Ser-Thr X +SRC Src P12931 human STXBP1 20910 O08599 Stxbp1 mouse Y473 450386 ERISEQTyQLSRWtP Sec1 X +SRC Src P12931 human CLTC 1213 Q00610 CLTC human Y1477 448069 LFITEEDyQALRtSI Clathrin X +SRC Src P12931 human GRF-1 2909 Q9NRY4 ARHGAP35 human Y1105 448941 RNEEENIysVPHDst RhoGAP_pG1_pG2 X +SRC Src P12931 human CDH5 12562 P55284 Cdh5 mouse Y685 455658 MDARPAVyTQVQkPP X X +SRC Src P12931 human PAK1 5058 Q13153 PAK1 human S144 448170 sNsQKyMsFtDksAE X 2606 +SRC Src P12931 human profilin 1 513895 P02584 PFN1 cow Y129 450514 GMINKKCyEMASHLR Profilin X +SRC Src P12931 human IKKB 3551 O14920 IKBKB human Y199 449633 ELLEQQKyTVTVDYW Pkinase X +SRC Src P12931 human RSK2 6197 P51812 RPS6KA3 human Y488 464203 DVyDDGKyVYVVTEL Pkinase X X +SRC Src P12931 human hnRNP P2 2521 P35637 FUS human Y526 50318713 QDrrErPy_______ X +SRC Src P12931 human p53 7157 P04637 TP53 human Y126 34824802 AkSVTCTySPALNkM P53 X X +SRC Src P12931 human coronin 7 79585 P57737 CORO7 human Y712 1871177706 SERQLLLyEAEALAG X +SRC Src P12931 human Src 6714 P12931 SRC human Y419 448234 RLIEDNEytARQGAk PK_Tyr_Ser-Thr X X 2101; 6943; 59548; 70926; 78740; 94361; 17320 +SRC Src P12931 human Tks5 14218 O89032 Sh3pxd2a mouse Y557 458193 VKyEEPEyDVPAFGF X +SRC Src P12931 human ROCK2 19878 P70336 Rock2 mouse Y722 464192 LADKNKIyEsIEEAK X +SRC Src P12931 human TIAM1 21844 Q60610 Tiam1 mouse Y384 7362700 DRARQGVyENFRREL X X +SRC Src P12931 human CTNND1 12388 P30999 Ctnnd1 mouse Y96 449495 QDHNHLLystIPRMQ X +SRC Src P12931 human TR-beta1 7068 P10828 THRB human Y406 976541 FLLAFEHyINYRKHH Hormone_recep X X +SRC Src P12931 human WNK4 65266 Q96J92 WNK4 human Y1115 40407607 PVWMNySySSLCLSS X +SRC Src P12931 human STAT3 6774 P40763 STAT3 human Y45 464379 IESQDWAyAASkESH STAT_int X +SRC Src P12931 human NDFIP2 54602 Q9NV92 NDFIP2 human Y171 15229530 TEVyGEFyPVPPPyS DUF2370 X X +SRC Src P12931 human RHBG 57127 Q9H310 RHBG human Y429 3647000 SPPDSQHyEDQVHWQ X +SRC Src P12931 human Lasp-1 3927 Q14847 LASP1 human Y171 451675 IPtsAPVyQQPQQQP X +SRC Src P12931 human PRKD1 5587 Q15139 PRKD1 human Y463 448648 NDTGsRYyKEIPLSE PH X +SRC Src P12931 human DDR2 4921 Q16832 DDR2 human Y741 456863 NLysGDyyRIQGRAV PK_Tyr_Ser-Thr X +SRC Src P12931 human G3BP-1 10146 Q13283 G3BP1 human Y133 7366803 VHNDIFRyQDEVFGG NTF2 X +SRC Src P12931 human SHC3 iso2 53358 Q92529-2 SHC3 human Y301 451259 PTGEAPTyVNTQQIP X +SRC Src P12931 human Ezrin 7430 P15311 EZR human Y146 448758 kEVHksGyLSsERLI FERM_M X X +SRC Src P12931 human RAB34 83871 Q9BZG1 RAB34 human Y247 455172 NsDDsNLyLTASkKK X X +SRC Src P12931 human HRas 3265 P01112 HRAS human Y32 15228776 QNHFVDEyDPtIEDs Ras X +SRC Src P12931 human CEACAM1 634 P13688 CEACAM1 human Y493 447777 NKMNEVtysTLNFEA X X +SRC Src P12931 human hnRNP K 3190 P61978 HNRNPK human Y72 455999 IkALRTDyNAsVsVP KH_1 X X +SRC Src P12931 human FBP1 8880 Q96AE4 FUBP1 human Y58 454058 TsLNsNDyGyGGQkR X +SRC Src P12931 human FAK 14083 P34152 Ptk2 mouse Y861 447965 PTGNQHIyQPVGKPD X +SRC Src P12931 human SHC3 iso2 53358 Q92529-2 SHC3 human Y257 451256 AGKEQTyyQGRHLGD X +SRC Src P12931 human Etk 660 P51813 BMX human Y566 448067 RYVLDDQyVsSVGTK PK_Tyr_Ser-Thr X X +SRC Src P12931 human CTNNG 3728 P14923 JUP human Y644 456973 RNEGTATyAAAVLFR X +SRC Src P12931 human KHSRP 8570 Q92945 KHSRP human Y688 462454 yYRQQAAyYGQtPGP DUF1897 X +SRC Src P12931 human coronin 7 79585 P57737 CORO7 human Y738 1871177707 PSTLLPSyDPDTGLV X +SRC Src P12931 human GRK2 282682 P21146 GRK2 cow Y13 456872 AVLADVSyLMAMEKS X +SRC Src P12931 human GBF1 8729 Q92538 GBF1 human Y1488 1875829508 DEGVPASyHTVSLQV X +SRC Src P12931 human GJA1 24392 P08050 Gja1 rat Y247 447814 VKGRsDPyHATTGPL X X +SRC Src P12931 human PXN 5829 P49023 PXN human Y88 448909 PQsssPVyGsSAKTs Paxillin X +SRC Src P12931 human SHC3 iso2 53358 Q92529-2 SHC3 human Y283 451257 RQGSSDIySTPEGKL X +SRC Src P12931 human LRP1 4035 Q07954 LRP1 human Y4507 451245 TNFTNPVyATLyMGG X X +SRC Src P12931 human G-alpha t1 281794 P04695 GNAT1 cow Y142 470102 CFDRASEyQLNDSAG G-alpha X +SRC Src P12931 human Ku70 2547 P12956 XRCC6 human Y530 463414 DEFkELVyPPDyNPE Ku_C X +SRC Src P12931 human SHC3 iso2 53358 Q92529-2 SHC3 human Y219 451258 DGSDHPyyNSIPSKM X +SRC Src P12931 human Villin 7429 P09327 VIL1 human Y46 469582 SFFDGDCyIILAIHK Gelsolin X +SRC Src P12931 human FIP1L1 81608 Q6UN15 FIP1L1 human Y110 450990 IKTGAPQyGsyGTAP X +SRC Src P12931 human occludin Q91049 OCLN chicken Y383 458611 ESQyETDyTTAVESS X +SRC Src P12931 human ITGB3 3690 P05106 ITGB3 human Y785 448013 stFTNItyRGT____ Integrin_b_cyt X +SRC Src P12931 human NPHP1 4867 O15259 NPHP1 human Y721 18449509 FDLSEQTyDFLGEMR X +SRC Src P12931 human DAPP1 27071 Q9UN19 DAPP1 human Y139 448325 kVEEPsIyEsVRVHT X X 13703 +SRC Src P12931 human OTUB1 55611 Q96FW1 OTUB1 human Y26 14821305 EGVNCLAyDEAIMAQ X +SRC Src P12931 human EYA3 2140 Q99504 EYA3 human Y532 1870640407 RFGKkVTyVVIGDGR X +SRC Src P12931 human VAV1 22324 P27870 Vav1 mouse Y174 447866 EAEGDEIyEDLMRLE X +SRC Src P12931 human GAB1 2549 Q13480 GAB1 human Y627 447948 KGDKQVEyLDLDLDs X X 3231; 3233 +SRC Src P12931 human PKD1 5310 P98161 PKD1 human Y4237 466930 NQATEDVyQLEQQLH X +SRC Src P12931 human PKCD 170538 P09215 Prkcd rat Y372 464424 ELKGKERyFAIKYLK Pkinase X +SRC Src P12931 human PRMT5 10419 O14744 PRMT5 human Y324 1869973804 DNLESQTyEVFEkDP PRMT5 X X +SRC Src P12931 human GAK 2580 O14976 GAK human Y412 63063501 kGDLDISyITSRIAV X X +SRC Src P12931 human Kv4.3 3752 Q9UK17 KCND3 human Y108 23045802 GKLHYPRyECISAYD BTB_2 X +SRC Src P12931 human STAT1 6772 P42224 STAT1 human Y701 447754 DGPkGtGyIktELIs X 9174; 9167; 5375; 25685; 8062; 8183; 8009; 55603; 7649; 25809; 57216; 45118; 39205; 88845; 88211; 76285; 90145 +SRC Src P12931 human AKAP8 10270 O43823 AKAP8 human Y311 3582467 KRkQFQLyEEPDTkL X +SRC Src P12931 human NEDD4 iso4 4734 P46934-4 NEDD4 human Y111 36436802 GQVDVPLyPLPTENP C2 X X +SRC Src P12931 human ATP4A 397552 P19156 ATP4A pig Y10 484290 KAENyELyQVELGPG H-K_ATPase_N X +SRC Src P12931 human ANXA2 403435 Q6TEQ7 ANXA2 dog Y24 449483 HSTPPSAyGSVKAYT X +SRC Src P12931 human KIF11 3832 P52732 KIF11 human Y125 4251398 ERsPNEEytWEEDPL Kinesin X X +SRC Src P12931 human GBF1 8729 Q92538 GBF1 human Y1245 1875829504 RVSHQVAyGLHELLK X +SRC Src P12931 human ARHGEF4 iso3 50649 Q9NR80-3 ARHGEF4 human Y94 3333400 VGSEEDLyDDLHSSS X X +SRC Src P12931 human AKAP8 10270 O43823 AKAP8 human Y436 40420003 TVEFLQEyIVNRNKK AKAP95 X +SRC Src P12931 human MMP14 4323 P50281 MMP14 human Y573 478362 GtPRRLLyCQRsLLD DUF3377 X X +SRC Src P12931 human SRRT 51593 Q9BXP5 SRRT human Y175 7366810 AVKRyNDyKLDFRRQ SERRATE_Ars2_N X +SRC Src P12931 human IKKG 8517 Q9Y6K9 IKBKG human Y374 473650 PLPPAPAyLssPLAL X +SRC Src P12931 human CBL 12402 P22682 Cbl mouse Y780 448531 sENEDDGyDVPKPPV X 3555 +CSNK2A1 CK2A1 P33674 rabbit FKBP4 100009148 P27124 FKBP4 rabbit T143 451093 EFKGEDLtDDEDGGI X +CSNK2A1 CK2A1 P33674 rabbit 4E-BP1 116636 Q62622 Eif4ebp1 rat S111 447526 KRAGGEEsQFEMDI_ eIF_4EBP X +CSNK2A1 CK2A1 P33674 rabbit 4E-BP1 116636 Q62622 Eif4ebp1 rat S99 457415 ASQSHLHsSPEDKRA eIF_4EBP X +CSNK2A1 CK2A1 P33674 rabbit PKAR2A 518399 P00515 PRKAR2A cow S77 456583 DAVADsEsEDEEDLD X +CSNK2A1 CK2A1 P33674 rabbit Calmodulin 24242 P0DP29 Calm3 rat T118 469586 TNLGEkLtDEEVDEM EF-hand_7 X +CSNK2A1 CK2A1 P33674 rabbit Calmodulin 24242 P0DP29 Calm3 rat S102 448706 kDGNGyIsAAELRHV EF-hand_7 X +CSNK2A1 CK2A1 P33674 rabbit PKAR2A 518399 P00515 PRKAR2A cow S75 4702645 VADAVADsEsEDEED X +CSNK2A1 CK2A1 P33674 rabbit EIF5 56783 Q07205 Eif5 rat S388 448030 KEAEEEssGGEEEDE W2 X +CSNK2A1 CK2A1 P33674 rabbit Calmodulin 24242 P0DP29 Calm3 rat T80 448704 MARKMkDtDsEEEIR X +CSNK2A1 CK2A1 P33674 rabbit MYH13 100302407 Q9GJP9 MYH13 rabbit S2 451520 ______MssDAEMAI X +CSNK2A1 CK2A1 P33674 rabbit EIF5 56783 Q07205 Eif5 rat S387 448029 LKEAEEEssGGEEED W2 X +CSNK2A1 CK2A1 P33674 rabbit HSP90A 3320 P07900 HSP90AA1 human S263 448662 PEIEDVGsDEEEEKK HSP90 X +CSNK2A1 CK2A1 P33674 rabbit MYH13 100302407 Q9GJP9 MYH13 rabbit S3 451521 _____MssDAEMAIF X +CSNK2A1 CK2A1 P33674 rabbit EIF5 56783 Q07205 Eif5 rat S174 449998 DKENGSVsTSETPPP X +CSNK2A1 CK2A1 P33674 rabbit GYS1 100008660 P13834 GYS1 rabbit S657 449790 RHSsPHQsEDEEEPR Glycogen_syn X +CSNK2A1 CK2A1 P33674 rabbit Calmodulin 24242 P0DP29 Calm3 rat S82 448705 RKMkDtDsEEEIREA X +CSNK2A1 CK2A1 P33674 rabbit HSP90B 3326 P08238 HSP90AB1 human S226 454114 kEREKEIsDDEAEEE HSP90 X +CSNK2A1 CK2A1 P33674 rabbit HSP90B 3326 P08238 HSP90AB1 human S255 449266 PKIEDVGsDEEDDsG HSP90 X +TAOK3 TAO3 Q9H2K8 human DNCLI2 234663 Q6PDL0 Dync1li2 mouse T202 4739826 PQRRGPLtSGsDEDS DLIC X +Flt1 VEGFR1 P35969 mouse PLCG1 18803 Q62077 Plcg1 mouse Y783 447667 EGRNPGFyVEANPMP X 2821; 14461; 14008; 25678; 88717 +Plk3 PLK3 Q60806 mouse PTEN 5728 P60484 PTEN human S370 448649 TSVtPDVsDNEPDHy X +Plk3 PLK3 Q60806 mouse SNCA 20617 O55042 Snca mouse S129 448278 SEAyEMPsEEGYQDY Synuclein X 23706; 87281 +Plk3 PLK3 Q60806 mouse PTEN 5728 P60484 PTEN human T366 449634 ASSsTSVtPDVsDNE X +Plk3 PLK3 Q60806 mouse CDC25A 993 P30304 CDC25A human S519 26342101 KsKREMYsRLKKL__ X +Plk3 PLK3 Q60806 mouse CDC25A 993 P30304 CDC25A human S513 26342100 RtWAGEKsKREMYsR X +Atr ATR Q9JKK8 mouse MCM3 17215 P25206 Mcm3 mouse S732 475062 sQEKtDDsQEtQDsQ X +Atr ATR Q9JKK8 mouse VAMP2 22318 P63044 Vamp2 mouse T35 12473004 SNRRLQQtQAQVDEV Synaptobrevin X +Atr ATR Q9JKK8 mouse MCM3 17215 P25206 Mcm3 mouse S725 475061 HtPKtDDsQEKtDDs X +Atr ATR Q9JKK8 mouse MCM3 4172 P25205 MCM3 human S728 475062 HtPKtADsQETkEsQ X +Atr ATR Q9JKK8 mouse p53 22059 P02340 Tp53 mouse S18 447490 IsLELPLsQEtFsGL P53_TAD X 9284; 9286; 12571; 56979 +Atr ATR Q9JKK8 mouse CREB 12912 Q01147 Creb1 mouse S107 451811 sVDsVTDsQKRREIL pKID X +Cilk1 ICK Q9JKV2 mouse KIF3A 16568 P28741 Kif3a mouse T674 33668514 MKLERPRtSKGKARP X X +Abl2 Arg Q4JIM5 mouse Arg 11352 Q4JIM5 Abl2 mouse Y272 456540 KCNKPTVyGVSPIHD X +Abl2 Arg Q4JIM5 mouse Arg 11352 Q4JIM5 Abl2 mouse Y439 447923 RLMTGDTytAHAGAK PK_Tyr_Ser-Thr X +Abl2 Arg Q4JIM5 mouse Arg 11352 Q4JIM5 Abl2 mouse Y568 456545 SSSSVVPyLPrLPLL X +Abl2 Arg Q4JIM5 mouse N-WASP 8976 O00401 WASL human Y256 450253 RETSkVIyDFIEkTG PBD X X +Abl2 Arg Q4JIM5 mouse Arg 11352 Q4JIM5 Abl2 mouse Y684 456546 ENQPHKKyELTGNFS X +Grk5 GRK5 Q8VEB1 mouse KOR-1 18387 P33534 Oprk1 mouse S369 449609 NtVQDPAsMRDVGGM X +Grk5 GRK5 Q8VEB1 mouse KOR-1 18387 P33534 Oprk1 mouse T357 52467201 MRMERQstNRVRNtV X +Grk5 GRK5 Q8VEB1 mouse KOR-1 18387 P33534 Oprk1 mouse S356 52467200 KMRMERQstNRVRNt X +Grk5 GRK5 Q8VEB1 mouse MOR-1 18390 P42866 Oprm1 mouse S375 447784 QNtREHPstANtVDR X 3451 +Grk5 GRK5 Q8VEB1 mouse KOR-1 18387 P33534 Oprk1 mouse T363 52467202 stNRVRNtVQDPAsM X +PIK3CB PIK3CB P42338 human PIK3CB 5291 P42338 PIK3CB human S1070 449881 TVRKDYRs_______ X +CDK3 CDK3 Q00526 human ER-alpha 2099 P03372 ESR1 human S104 448099 FPPLNsVsPsPLMLL Oest_recep X X +CDK3 CDK3 Q00526 human TFCP2 7024 Q12800 TFCP2 human S309 7965105 SLGEGNGsPNHQPEP X X +CDK3 CDK3 Q00526 human EVI1 2122 Q03112 MECOM human S624 4702996 KMFKDkVsPLQNLAS X +CDK3 CDK3 Q00526 human LIN9 286826 Q5TKA1 LIN9 human T96 3201645 KFtAtMstPDKKASQ X X +CDK3 CDK3 Q00526 human NFAT3 4776 Q14934 NFATC4 human S259 31859079 APGPtPAsPRPAsPC X +CDK3 CDK3 Q00526 human ER-alpha 2099 P03372 ESR1 human S118 448101 LHPPPQLsPFLQPHG Oest_recep X X 2511 +CDK3 CDK3 Q00526 human Notch 1 4851 P46531 NOTCH1 human S2513 35483201 EHPFLtPsPEsPDQW X X +CDK3 CDK3 Q00526 human Notch 1 4851 P46531 NOTCH1 human T2511 483083 VPEHPFLtPsPEsPD X X +CDK3 CDK3 Q00526 human C/EBP-beta 24253 P21272 Cebpb rat T189 447878 SSSsPPGtPSPADAK X 3084 +CDK3 CDK3 Q00526 human ER-alpha 2099 P03372 ESR1 human S106 448100 PLNsVsPsPLMLLHP Oest_recep X X +CDK3 CDK3 Q00526 human Jun 3725 P05412 JUN human S73 447943 VGLLkLAsPELERLI Jun X X 9164; 3270; 8752; 12714; 77955 +CDK3 CDK3 Q00526 human ATF-1 466 P18846 ATF1 human S63 449762 GILARRPsyRKILkD pKID X X 4095; 14228; 14001 +CDK3 CDK3 Q00526 human Jun 3725 P05412 JUN human S63 447686 kNsDLLtsPDVGLLk Jun X X 5464; 9261; 2361; 97721; 91952 +CDK3 CDK3 Q00526 human CABLES1 91768 Q8TDN4 CABLES1 human S313 4274722 RCRtLsGsPRPKNFK X X +CDK3 CDK3 Q00526 human Rb 5925 P06400 RB1 human S807 447980 PGGNIyIsPLksPyk Rb_C X 9308; 8974; 4277; 40283; 8957; 8516; 11917; 99274; 41359; 75864; 72443 +CDK3 CDK3 Q00526 human Notch 1 4851 P46531 NOTCH1 human S2516 35483202 FLtPsPEsPDQWsss X +CDK3 CDK3 Q00526 human Rb 5925 P06400 RB1 human S811 448717 IyIsPLksPykIsEG Rb_C X 9308; 8974; 4277; 40283; 8957; 8516; 11917; 41359; 75864; 63276 +WNK2 WNK2 Q9Y3S1 human WNK1 65125 Q9H4A3 WNK1 human S382 454105 kRAsFAKsVIGTPEF Pkinase X +WNK2 WNK2 Q9Y3S1 human STLK3 27347 Q9UEW8 STK39 human T354 483899 IEkLLtRtPDIAQRA X +WNK2 WNK2 Q9Y3S1 human STLK3 27347 Q9UEW8 STK39 human S371 456506 VRRVPGssGHLHKTE X +Mapk11 P38B Q9WUI1 mouse E2F1 1869 Q01094 E2F1 human T433 447871 DCDFGDLtPLDF___ X +Mapk11 P38B Q9WUI1 mouse E2F1 1869 Q01094 E2F1 human S403 447870 PEEFISLsPPHEALD X +Mapk11 P38B Q9WUI1 mouse MAPKAPK5 17165 O54992 Mapkapk5 mouse T182 450093 VDQGDLMtPQFTPYY Pkinase X +Mapk11 P38B Q9WUI1 mouse SMARCD3 66993 Q6P9Z1 Smarcd3 mouse T229 8097074 HLVEWHRtPTTQETD X +Csnk2a1 CK2A1 Q60737 mouse CD45 19264 P06800 Ptprc mouse S993 449973 SEPEsDEssDDDsDS Y_phosphatase X X +Csnk2a1 CK2A1 Q60737 mouse CUTL1 13047 P53564 Cux1 mouse S1155 457411 ILGLTQGsVSDLLAR CUT X +Csnk2a1 CK2A1 Q60737 mouse POLR2A 20020 P08775 Polr2a mouse S1616 450204 TPQSPSYsPtsPSYS RNA_pol_Rpb1_R X 4735; 13499; 13546; 31262 +Csnk2a1 CK2A1 Q60737 mouse CUTL1 13047 P53564 Cux1 mouse S972 457410 VLGLSQGsVSDMLSR CUT X +Csnk2a1 CK2A1 Q60737 mouse Myb 396244 P01103 MYB chicken S12 448187 PRHSIYssDDDEEDV X +Csnk2a1 CK2A1 Q60737 mouse HSF1 15499 P38532 Hsf1 mouse T142 449066 DSVTRLLtDVQLMKG X +Csnk2a1 CK2A1 Q60737 mouse SIRT1 93759 Q923E4 Sirt1 mouse S164 6006904 DDRTSHAsSSDWTPR X X +Csnk2a1 CK2A1 Q60737 mouse DARPP-32 19049 Q60829 Ppp1r1b mouse S97 457675 NLsENQAsEEEDELG DARPP-32 X 3401 +Csnk2a1 CK2A1 Q60737 mouse CUTL1 13047 P53564 Cux1 mouse S583 457409 VLGLSQGsVSEILAR CUT X +Csnk2a1 CK2A1 Q60737 mouse HP1 alpha 12419 Q61686 Cbx5 mouse S11 476162 KTKRtADssssEDEE X +Csnk2a1 CK2A1 Q60737 mouse CACNA1A 12286 P97445 Cacna1a mouse S2363 4713052 AHDAYsEsEDDWC__ X +Csnk2a1 CK2A1 Q60737 mouse PPPM1A 19042 P49443 Ppm1a mouse S375 452154 YKNDDtDsAstDDMW X +Csnk2a1 CK2A1 Q60737 mouse p53 22059 P02340 Tp53 mouse S389 447535 VkkVGPDsD______ X X 9281 +Csnk2a1 CK2A1 Q60737 mouse Cortactin 13043 Q60598 Cttn mouse T24 471533 GGADDWEtDPDFVND X +Csnk2a1 CK2A1 Q60737 mouse MYBPC3 17868 O70468 Mybpc3 mouse S327 30324204 ILRQAPPsEYERIAF THB X +Csnk2a1 CK2A1 Q60737 mouse CASP9 12371 Q8C3Q9 Casp9 mouse S348 484609 SQGRTLDsDSEPDAV Peptidase_C14 X +Csnk2a1 CK2A1 Q60737 mouse CTNNB1 1499 P35222 CTNNB1 human T393 449562 RNLSDAAtkQEGMEG X +Csnk2a1 CK2A1 Q60737 mouse MYBPC3 17868 O70468 Mybpc3 mouse S47 4699355 VRWQRDGsDItANDK I-set X +Csnk2a1 CK2A1 Q60737 mouse BID 12122 P70444 Bid mouse T58 448406 DLEDELQtDGsQAsR BID X +Csnk2a1 CK2A1 Q60737 mouse PAX3 18505 P24610 Pax3 mouse S205 4145506 APQsDEGsDIDsEPD X +Csnk2a1 CK2A1 Q60737 mouse Myb 396244 P01103 MYB chicken S11 448186 RPRHSIYssDDDEED X +Csnk2a1 CK2A1 Q60737 mouse CD45 19264 P06800 Ptprc mouse S990 449972 SKESEPEsDEssDDD Y_phosphatase X X +Csnk2a1 CK2A1 Q60737 mouse HP1 alpha 12419 Q61686 Cbx5 mouse S14 476165 RtADssssEDEEEyV X +Csnk2a1 CK2A1 Q60737 mouse MYBPC3 17868 O70468 Mybpc3 mouse S72 4699361 tLTVRDAsPDDQGSY I-set X +Csnk2a1 CK2A1 Q60737 mouse NRL 4901 P54845 NRL human S117 1880112600 PHGYYPGsPEETGAQ X +Csnk2a1 CK2A1 Q60737 mouse BMAL1 11865 Q9WTL8 Bmal1 mouse S97 7359500 RRRDKMNsFIDELAS HLH X +Csnk2a1 CK2A1 Q60737 mouse CACNA1A 12286 P97445 Cacna1a mouse S2361 4713048 RGAHDAYsEsEDDWC X +Csnk2a1 CK2A1 Q60737 mouse IkB-alpha 18035 Q9Z1E3 Nfkbia mouse S293 451525 EESYDTEsEFTEDEL X +Csnk2a1 CK2A1 Q60737 mouse ODC 18263 P00860 Odc1 mouse S303 451283 VWKEQPGsDDEDESN Orn_DAP_Arg_deC X +Csnk2a1 CK2A1 Q60737 mouse SNCA 6622 P37840 SNCA human S129 448278 NEAyEMPsEEGyQDy Synuclein X 23706; 87281 +Csnk2a1 CK2A1 Q60737 mouse BMAL1 iso4 11865 Q9WTL8-4 Bmal1 mouse S90 7359500 RRRDKMNsFIDELAS HLH X +Csnk2a1 CK2A1 Q60737 mouse SNCA 20617 O55042 Snca mouse S129 448278 SEAyEMPsEEGYQDY Synuclein X 23706; 87281 +Csnk2a1 CK2A1 Q60737 mouse Ikaros 22778 Q03267 Ikzf1 mouse T23 4828303 ESPPVSDtPDEGDEP X +Csnk2a1 CK2A1 Q60737 mouse HP1 alpha 12419 Q61686 Cbx5 mouse S97 4730523 RkssFsNsADDIkSK X +Csnk2a1 CK2A1 Q60737 mouse NFE2L1 18023 Q61985 Nfe2l1 mouse S497 28700306 EGAVGYSsDSETLDL X +Csnk2a1 CK2A1 Q60737 mouse MYBPC3 17868 O70468 Mybpc3 mouse S25 30324201 SAEVTAGsAAVFEAE I-set X +Csnk2a1 CK2A1 Q60737 mouse MYBPC3 17868 O70468 Mybpc3 mouse S282 471080 AGAGRRtsDsHEDAG X +Csnk2a1 CK2A1 Q60737 mouse LPIN1 14245 Q91ZP3 Lpin1 mouse S285 471346 SRPstPKsDsELVSK X +Csnk2a1 CK2A1 Q60737 mouse MYBPC3 17868 O70468 Mybpc3 mouse T50 30324202 QRDGsDItANDKYGL I-set X +Csnk2a1 CK2A1 Q60737 mouse Ikaros 22778 Q03267 Ikzf1 mouse S293 15404028 LSDMPYDsANYEKED X +Csnk2a1 CK2A1 Q60737 mouse HP1 alpha 12419 Q61686 Cbx5 mouse S12 3190486 TKRtADssssEDEEE X +Csnk2a1 CK2A1 Q60737 mouse PU.1 20375 P17433 Spi1 mouse S148 455900 QsPPLEVsDGEADGL X +Csnk2a1 CK2A1 Q60737 mouse Nur77 15370 P12813 Nr4a1 mouse S151 1255792405 STPNFQPsQLSPWDG X +Csnk2a1 CK2A1 Q60737 mouse PPPM1A 19042 P49443 Ppm1a mouse S377 452155 NDDtDsAstDDMW__ X +Csnk2a1 CK2A1 Q60737 mouse Myb 17863 P06876 Myb mouse S11 448186 RPRHSIYssDEDDED X +Csnk2a1 CK2A1 Q60737 mouse PAX3 18505 P24610 Pax3 mouse S209 18744501 DEGsDIDsEPDLPLK X +Csnk2a1 CK2A1 Q60737 mouse CD45 19264 P06800 Ptprc mouse S994 449974 EPEsDEssDDDsDSE Y_phosphatase X X +Csnk2a1 CK2A1 Q60737 mouse POLR2A 20020 P08775 Polr2a mouse S1619 447616 SPSYsPtsPSYSPTS RNA_pol_Rpb1_R X 4735; 13523; 13546; 67221 +Csnk2a1 CK2A1 Q60737 mouse LRP6 16974 O88572 Lrp6 mouse S1579 23122945 tPRSQYLsAEENYES X X +Csnk2a1 CK2A1 Q60737 mouse Ikaros 22778 Q03267 Ikzf1 mouse S101 4828301 GSHRDQGsSALSGVG X +Csnk2a1 CK2A1 Q60737 mouse CD45 19264 P06800 Ptprc mouse S998 449975 DEssDDDsDSEETSK Y_phosphatase X X +Csnk2a1 CK2A1 Q60737 mouse HP1 alpha 12419 Q61686 Cbx5 mouse S13 476164 KRtADssssEDEEEy X +Csnk2a1 CK2A1 Q60737 mouse TRPM3 226025 Q5F4S9 Trpm3 mouse S1184 1875848400 CRWRKHEsDQDERDY X X +Csnk2a1 CK2A1 Q60737 mouse Myb 17863 P06876 Myb mouse S12 448187 PRHSIYssDEDDEDI X +Csnk2a1 CK2A1 Q60737 mouse HDAC2 15182 P70288 Hdac2 mouse S394 449930 EDAVHEDsGDEDGED X 61458; 69238 +Csnk2a1 CK2A1 Q60737 mouse PTEN 19211 O08586 Pten mouse S370 448649 TSVtPDVsDNEPDHY X +Csnk2a1 CK2A1 Q60737 mouse MYBPC3 17868 O70468 Mybpc3 mouse T33 30324200 AAVFEAEtERSGVMV I-set X +Csnk2a1 CK2A1 Q60737 mouse FMR1 14265 P35922 Fmr1 mouse S499 469583 NSEAsNAsETESDHR FXMRP1_C_core X +Csnk2a1 CK2A1 Q60737 mouse LPIN1 14245 Q91ZP3 Lpin1 mouse S287 471347 PstPKsDsELVSKsA X +Csnk2a1 CK2A1 Q60737 mouse VAMP4 53330 O70480 Vamp4 mouse S30 454285 RNLLEDDsDEEEDFF X +Csnk2a1 CK2A1 Q60737 mouse KLF1 16596 P46099 Klf1 mouse T23 457383 TLGQFLDtQEDFLKW EKLF_TAD1 X X +Csnk2a1 CK2A1 Q60737 mouse MYBPC3 17868 O70468 Mybpc3 mouse S105 17660717 APPEkAEsEVAPGAP X +Csnk2a1 CK2A1 Q60737 mouse HDAC6 10013 Q9UBN7 HDAC6 human S458 18944908 EEDNVEEsEEEGPWE X +Csnk2a1 CK2A1 Q60737 mouse CACYBP 12301 Q9CXW3 Cacybp mouse T184 15402545 KEKPSYDtEADPSEG SGS X +Csnk2a1 CK2A1 Q60737 mouse MEF2C 17260 Q8CFN5 Mef2c mouse S59 447999 NKLFQYAsTDMDKVL X +Csnk2a1 CK2A1 Q60737 mouse Ikaros 22778 Q03267 Ikzf1 mouse S13 4828300 GQDMSQVsGKESPPV X +Csnk2a1 CK2A1 Q60737 mouse C/EBP-beta 24253 P21272 Cebpb rat S223 408589401 kkAVDKLsDEYKMRR bZIP_2 X +NTRK2 TrkB Q16620 human TrkB 4915 Q16620 NTRK2 human Y516 448813 PVIENPQyFGITNSQ X 4619 +NTRK2 TrkB Q16620 human PAX5 18507 Q02650 Pax5 mouse Y102 34364233 VVEKIAEyKRQNPTM PAX X X +NTRK2 TrkB Q16620 human SHC3 iso2 53358 Q92529-2 SHC3 human Y218 451254 GDGSDHPyyNSIPSK X +NTRK2 TrkB Q16620 human SHC3 iso2 53358 Q92529-2 SHC3 human Y256 451255 FAGKEQTyyQGRHLG X +NTRK2 TrkB Q16620 human Kv1.3 3738 P22001 KCNA3 human Y499 451294 EGEEQSQyMHVGsCQ X +NTRK2 TrkB Q16620 human Kv1.3 3738 P22001 KCNA3 human Y161 3820926 PSFDAILyyyQSGGR BTB_2 X +NTRK2 TrkB Q16620 human NLGN1 192167 Q99K10 Nlgn1 mouse Y782 1008111 RTACPPDyTLAMRRS X +NTRK2 TrkB Q16620 human Kv1.3 3738 P22001 KCNA3 human Y162 3820931 SFDAILyyyQSGGRI BTB_2 X +NTRK2 TrkB Q16620 human SHC3 iso2 53358 Q92529-2 SHC3 human Y301 451259 PTGEAPTyVNTQQIP X +NTRK2 TrkB Q16620 human SHC3 iso2 53358 Q92529-2 SHC3 human Y257 451256 AGKEQTyyQGRHLGD X +NTRK2 TrkB Q16620 human SHC3 iso2 53358 Q92529-2 SHC3 human Y283 451257 RQGSSDIySTPEGKL X +NTRK2 TrkB Q16620 human SHC3 iso2 53358 Q92529-2 SHC3 human Y219 451258 DGSDHPyyNSIPSKM X +NTRK2 TrkB Q16620 human Kv1.3 3738 P22001 KCNA3 human Y163 3820936 FDAILyyyQSGGRIR BTB_2 X +RPS6KA4 MSK2 O75676 human H3 360198 P68433 H3c1 mouse S10 455676 tkQTARkstGGkAPr Histone X 9701; 9711; 9606; 3465; 3642; 3377; 3475; 3458; 5764; 47398; 8481; 8552; 53348; 29237; 66065; 43185; 64522; 52725 +RPS6KA4 MSK2 O75676 human H3 8350 P68431 H3C1 human S28 455677 ATkAArksAPATGGV Histone X 9713 +RPS6KA4 MSK2 O75676 human H3 360198 P68433 H3c1 mouse K14 458954 ARkstGGkAPrkQLA Histone X 9677; 7627; 26828 +RPS6KA4 MSK2 O75676 human CREB 1385 P16220 CREB1 human S119 448228 EILsRRPsyRkILND pKID X 9187; 9196; 9198; 4095; 14228; 14001; 39561; 80120; 44864; 54960; 95995 +RPS6KA4 MSK2 O75676 human ataxin-1 6310 P54253 ATXN1 human S775 449110 AtRKRRWsAPESRKL X +RPS6KA4 MSK2 O75676 human NFkB-p65 5970 Q04206 RELA human S276 447798 sMQLRRPsDRELsEP RHD_dimer X +RPS6KA4 MSK2 O75676 human MSK2 8986 O75676 RPS6KA4 human S196 450046 EEkERtFsFCGTIEY Pkinase X +PRKACA PKACA P36887 pig FBPase 24362 P19112 Fbp1 rat S357 449856 AREsPVHsICDELF_ X +PRKACA PKACA P36887 pig FBPase 24362 P19112 Fbp1 rat S339 451645 YNkDKAKsRPsLPLP X +PRKACA PKACA P36887 pig CACNA1C BAA34185.2 CACNA1C guinea pig S1574 467228 VACKRLVsMNMPLNS GPHH X +PRKACA PKACA P36887 pig PAH 24616 P04176 Pah rat S16 449074 GVLSRKLsDFGQETS X +PRKACA PKACA P36887 pig H3 8350 P68431 H3C1 human S10 455676 tkQtArkstGGkAPr Histone X 9701; 9711; 9606; 3465; 3642; 3377; 3475; 3458; 5764; 47398; 8481; 8552; 53348; 29237; 66065; 43185; 64522; 52725 +PRKACA PKACA P36887 pig CAMKK1 84254 Q8N5S9 CAMKK1 human S74 452115 sLsARkLsLQERPAG X +PRKACA PKACA P36887 pig FBPase 24362 P19112 Fbp1 rat S342 449869 DKAKsRPsLPLPQSR X +PRKACA PKACA P36887 pig CAMKK1 84254 Q8N5S9 CAMKK1 human S475 486103 RrEErsMsAPGNLLV X +PRKACA PKACA P36887 pig GFAP 396562 F1RR02 GFAP pig S8 449618 MERRRVtsAARRsYV Filament_head X +PRKACA PKACA P36887 pig CACNA1C BAA34185.2 CACNA1C guinea pig S1699 4714250 PEIRRAIsGDLTAEE CAC1F_C X +PRKACA PKACA P36887 pig CACNA1C BAA34185.2 CACNA1C guinea pig S1626 10349704 KKIWKRTsMKLLDQV Ca_chan_IQ X +PRKACA PKACA P36887 pig FGF2 2247 P09038 FGF2 human T254 451676 TYRsRKytSWYVALk FGF X +PRKACA PKACA P36887 pig HMGN1 614915 P02316 HMGN1 cow S7 447788 _MPKRKVsSAEGAAK HMG14_17 X +PRKACA PKACA P36887 pig GFAP 396562 F1RR02 GFAP pig S34 449621 LGPGPRLsLARMPPP Filament_head X +PRKACA PKACA P36887 pig PKACA P36887 PRKACA pig S11 469998 AAAAKKGsEQESVKE X +PRKACA PKACA P36887 pig myomesin 1 8736 P52179 MYOM1 human S618 451407 ARLKSRPsAPWTGQI X +PRKACA PKACA P36887 pig GFAP 396562 F1RR02 GFAP pig T7 449617 _MERRRVtsAARRsY Filament_head X +PRKACA PKACA P36887 pig PKACA P36887 PRKACA pig S339 449886 EEEEIRVsINEKCGK X +PRKACA PKACA P36887 pig GFAP 396562 F1RR02 GFAP pig S13 449619 VtsAARRsYVSSLET Filament_head X +PRKACA PKACA P36887 pig TRIM32 22954 Q13049 TRIM32 human S651 27717300 SYHLRRYsTP_____ X +ILK ILK Q13418 human MYPT1 396020 Q90623 PPP1R12A chicken T709 3073900 DLQEAEKtIGRSRSt X +ILK ILK Q13418 human Akt1 207 P31749 AKT1 human S473 447855 RPHFPQFsysAsGtA Pkinase_C X X 9271; 3787; 4060; 4051; 5102; 4058; 2336; 2337; 4075; 4070; 5012; 4071; 92982; 5315; 9563; 9018; 12694; 52240; 11962; 15116; 88106; 26580; 68035; 31957; 23430; 20235 +ILK ILK Q13418 human PPP1R14A 94274 Q96A00 PPP1R14A human T38 449098 QkRHARVtVkYDRRE PP1_inhibitor X +ILK ILK Q13418 human KEPI 81706 Q8TAE6 PPP1R14C human T73 10296602 RHQQGKVtVkYDRKE PP1_inhibitor X +ILK ILK Q13418 human MYPT1 396020 Q90623 PPP1R12A chicken T695 448587 ARQSRRstQGVTLTD X 5163 +ILK ILK Q13418 human Cofilin-1 29271 P45592 Cfl1 rat S3 448444 _____MAsGVAVsDG X 3313; 3311 +ILK ILK Q13418 human MRLC2 103910 O14950 MYL12B human S20 448595 KRPQRAtsNVFAMFD X X +ILK ILK Q13418 human NACA 4666 E9PAV3 NACA human S1906 454238 PELEEQDsTQATTQQ X X +ILK ILK Q13418 human Akt1 11651 P31750 Akt1 mouse S473 447855 RPHFPQFsysAsGtA Pkinase_C X 9271; 3787; 4060; 4051; 5102; 4058; 2336; 2337; 4075; 4070; 5012; 4071; 92982; 5315; 9563; 9018; 12694; 52240; 11962; 15116; 88106; 26580; 68035; 31957; 23430; 20235 +ILK ILK Q13418 human PPP1R14B 26472 Q96C90 PPP1R14B human T57 1904503 VRRQGKVtVkYDRKE PP1_inhibitor X +ILK ILK Q13418 human MYPT1 396020 Q90623 PPP1R12A chicken T495 1856024 RLAYVAPtIPRRLAS X +ILK ILK Q13418 human MRLC2 103910 O14950 MYL12B human T19 448596 KKRPQRAtsNVFAMF X +GRK5 GRK5 P43249 cow GRK5 281801 P43249 GRK5 cow S484 451511 VLDIEQFstVKGVNL X +GRK5 GRK5 P43249 cow ADRB2 154 P07550 ADRB2 human S355 458916 KAyGNGyssNGNtGE X +GRK5 GRK5 P43249 cow ADRB2 154 P07550 ADRB2 human S356 458917 AyGNGyssNGNtGEQ X +GRK5 GRK5 P43249 cow GRK5 281801 P43249 GRK5 cow T485 451512 LDIEQFstVKGVNLD X +TESK1 TESK1 Q15569 human Cofilin-1 1072 P23528 CFL1 human S3 448444 _____MAsGVAVsDG X 3313; 3311 +VRK1 VRK1 Q99986 human VRK1 7443 Q99986 VRK1 human S376 15416617 GVEDTEWsNtQtEEA X +VRK1 VRK1 Q99986 human coilin 8161 P38432 COIL human S184 11329300 NEEAKRKsPKKKEKC Coilin_N X X +VRK1 VRK1 Q99986 human p53 7157 P04637 TP53 human T18 447541 EPPLsQEtFsDLWkL P53_TAD X X 2529 +VRK1 VRK1 Q99986 human H3 8350 P68431 H3C1 human T3 455678 _____ArtkQtArks Histone X X 9714; 13576 +VRK1 VRK1 Q99986 human H3 8350 P68431 H3C1 human S10 455676 tkQtArkstGGkAPr Histone X X 9701; 9711; 9606; 3465; 3642; 3377; 3475; 3458; 5764; 47398; 8481; 8552; 53348; 29237; 66065; 43185; 64522; 52725 +VRK1 VRK1 Q99986 human ATF-2 1386 P15336 ATF2 human T73 451439 ADQtPtPtRFLkNCE X X +VRK1 VRK1 Q99986 human BAF 8815 O75531 BANF1 human S4 458302 ____MttsQkHRDFV BAF X X +VRK1 VRK1 Q99986 human BAF 8815 O75531 BANF1 human T3 7105313 _____MttsQkHRDF BAF X X +VRK1 VRK1 Q99986 human VRK1 7443 Q99986 VRK1 human T386 1868585000 QtEEAIQtRSRTRKR X X +VRK1 VRK1 Q99986 human Jun 3725 P05412 JUN human S73 447943 VGLLkLAsPELERLI Jun X X 9164; 3270; 8752; 12714; 77955 +VRK1 VRK1 Q99986 human ATF-2 1386 P15336 ATF2 human S62 451440 FGPARNDsVIVADQt X X +VRK1 VRK1 Q99986 human p53 22059 P02340 Tp53 mouse T21 447541 ELPLsQEtFsGLWKL P53_TAD X +VRK1 VRK1 Q99986 human H2A.1 8329 P0C0S8 H2AC17 human T120 482914 AVLLPkktEsHHkAk Histone_H2A_C X X +VRK1 VRK1 Q99986 human Jun 3725 P05412 JUN human S63 447686 kNsDLLtsPDVGLLk Jun X X 5464; 9261; 2361; 97721; 91952 +VRK1 VRK1 Q99986 human PXR 8856 O75469 NR1I2 human S350 4668103 MQAISLFsPDRPGVL Hormone_recep X X +VRK1 VRK1 Q99986 human BAF 8815 O75531 BANF1 human T2 7105310 ______MttsQkHRD BAF X X +VRK1 VRK1 Q99986 human Tip60 10524 Q92993 KAT5 human T158 10800707 VEVVsPAtPVPSETA X +VRK1 VRK1 Q99986 human VRK1 7443 Q99986 VRK1 human T355 483969 GLkAKTItKKRKKEI X +Tie1 TIE1 Q06806 mouse TIE1 21846 Q06806 Tie1 mouse Y1113 451279 MLEARKAyVNMSLFE X X +PRKCI PKCI P41743 human MARK2 2011 Q7KZI7 MARK2 human T596 453427 rGVssRstFHAGQLR X +PRKCI PKCI P41743 human AMOT 154796 Q4VCS5 AMOT human T750 56589712 DMEGRIKtLHAQIIE Angiomotin_C X +PRKCI PKCI P41743 human Tau iso8 4137 P10636-8 MAPT human S352 487459 DFKDrVQskIGsLDN Tubulin-binding X +PRKCI PKCI P41743 human ROCK1 6093 Q13464 ROCK1 human T1334 1210778 AsPRtLstRstANQs X X +PRKCI PKCI P41743 human Ezrin 7430 P15311 EZR human T567 448104 QGRDkyKtLRQIRQG ERM_C X X 3141; 3726; 32600 +PRKCI PKCI P41743 human SP1 6667 P08047 SP1 human S59 452233 GGQEsQPsPLALLAA X +PRKCI PKCI P41743 human ROCK1 6093 Q13464 ROCK1 human S1333 4935818 RAsPRtLstRstANQ X X +PRKCI PKCI P41743 human NUMB 8650 P49757 NUMB human S295 470030 sPFKRQLsLRINELP NumbF X +PRKCI PKCI P41743 human MARK3 4140 P27448 MARK3 human T564 466001 RGTASRStFHGQPRE X +PRKCI PKCI P41743 human CDK7 1022 P50613 CDK7 human T170 448306 GsPNRAytHQVVtRW Pkinase X X +PRKCI PKCI P41743 human GLI1 2735 P08151 GLI1 human S243 27708601 DCRWDGCsQEFDSQE X +PRKCI PKCI P41743 human AID 11628 Q9WVE0 Aicda mouse S3 20660600 _____MDsLLMKQKK X +PRKCI PKCI P41743 human Ezrin 22350 P26040 Ezr mouse T567 448104 QGRDKYKtLRQIRQG ERM_C X X 3141; 3726; 32600 +PRKCI PKCI P41743 human ROCK1 6093 Q13464 ROCK1 human T1337 18261228 RtLstRstANQsFRK X X +PRKCI PKCI P41743 human NUMB 8650 P49757 NUMB human S7 487518 _MNKLRQsFRRKkDV X X +PRKCI PKCI P41743 human NUMB 8650 P49757 NUMB human S276 456490 EQLARQGsFrGFPAL NumbF X 4140; 9878 +PRKCI PKCI P41743 human Tau iso8 4137 P10636-8 MAPT human S324 449328 kVtskCGsLGNIHHk Tubulin-binding X +PRKCI PKCI P41743 human KEPI 81706 Q8TAE6 PPP1R14C human T73 10296602 RHQQGKVtVkYDRKE PP1_inhibitor X +PRKCI PKCI P41743 human FBXW7 55294 Q969H0 FBXW7 human S10 17337000 QELLSVGsKRRRTGG X +PRKCI PKCI P41743 human DOC2B 8447 Q14184 DOC2B human S34 1267669105 IRPIKQIsDYFPRFP X X +PRKCI PKCI P41743 human FBXW7 55294 Q969H0 FBXW7 human S18 17337001 KRRRTGGsLRGNPSs X +PRKCI PKCI P41743 human ROCK1 6093 Q13464 ROCK1 human T1024 20609219 IDRKKANtQDLRKKE X X +PRKCI PKCI P41743 human Tau iso8 4137 P10636-8 MAPT human S293 449327 NVQskCGsKDNIkHV Tubulin-binding X +PRKCI PKCI P41743 human BAD 572 Q92934 BAD human S99 447862 PFrGrsRsAPPNLWA Bcl-2_BAD X X 9295; 5286; 4366 +PRKCI PKCI P41743 human UBF 7343 P17480 UBTF human S412 472620 EkPKRPVsAMFIFSE HMG_box X X +PRKCI PKCI P41743 human IRAK1 16179 Q62406 Irak1 mouse T66 447722 CERSEQRtASVLWPW Death X +PRKCI PKCI P41743 human ELF3 1999 P78545 ELF3 human S68 54363505 GEQPQFWsKTQVLDW SAM_PNT X +PRKCI PKCI P41743 human PARD6A 50855 Q9NPB6 PARD6A human S345 15714600 RGDGSGFsL______ X +PRKCI PKCI P41743 human ECT2 1894 Q9H8V3 ECT2 human T359 483847 YLYEKANtPELKksV X X +PRKCI PKCI P41743 human AMOT 154796 Q4VCS5 AMOT human T536 56589713 GSEDTRKtIsQLFAK X +PRKCI PKCI P41743 human GLI1 2735 P08151 GLI1 human T304 27708600 GEKPHKCtFEGCRKS X +PRKCI PKCI P41743 human BAD 572 Q92934 BAD human S75 447860 EIRsRHssyPAGtED Bcl-2_BAD X X 9291; 5284; 9296; 5193; 11865; 94223 +PRKCI PKCI P41743 human Vimentin 7431 P08670 VIM human S34 455454 srsyVttstrtysLG Filament_head X +PRKCI PKCI P41743 human KLF10 7071 Q13118 KLF10 human S384 5263526 GkTYFKssHLkAHTR X +PRKCI PKCI P41743 human Tau iso8 4137 P10636-8 MAPT human S258 487453 PDLkNVKskIGstEN Tubulin-binding X +PRKCI PKCI P41743 human EZH2 2146 Q15910 EZH2 human T487 452848 APAEDVDtPPRKKKR X +PRKCI PKCI P41743 human EZH2 2146 Q15910 EZH2 human S690 58924703 KIRFANHsVNPNCyA SET X +PRKCI PKCI P41743 human Cortactin 2017 Q14247 CTTN human S261 13879503 EKLQLHEsQkDyktG HS1_rep X X +PRKCI PKCI P41743 human P70S6KB 6199 Q9UBS0 RPS6KB2 human S473 450071 PPSGTKKsKRGRGRP X +PRKCI PKCI P41743 human BAD 572 Q92934 BAD human S118 447863 GRELRRMsDEFVDsF Bcl-2_BAD X X 9297 +PRKCI PKCI P41743 human YKT6 10652 O15498 YKT6 human S174 27456090 LDDLVsksEVLGtQS Synaptobrevin X +PRKCI PKCI P41743 human Vimentin 7431 P08670 VIM human S39 451766 ttstrtysLGsALrP Filament_head X 13614 +PRKCI PKCI P41743 human Fe65 11785 Q9QXJ1 Apbb1 mouse S459 13309858 VWGVGRDsGSNRDFA PID X +PRKCI PKCI P41743 human ROCK1 6093 Q13464 ROCK1 human S1341 1216639 tRstANQsFRKVVKN X X +PRKCI PKCI P41743 human AID 11628 Q9WVE0 Aicda mouse T140 6835300 GVQIGIMtFKDYFYC APOBEC2 X +PRKCI PKCI P41743 human GluR1 50592 P19490 Gria1 rat S836 467226 CYkSRSEskRMkGFC X +PRKCI PKCI P41743 human AMOT 154796 Q4VCS5 AMOT human S538 56589714 EDTRKtIsQLFAKNk X +PRKCI PKCI P41743 human p300 2033 Q09472 EP300 human S89 447592 SELLRSGsSPNLNMG X +PRKCI PKCI P41743 human PAR3-alpha 56288 Q8TEW0 PARD3 human S827 467266 REGFGRQsMSEKRtK X +PRKCI PKCI P41743 human KLF10 7071 Q13118 KLF10 human T445 20573500 FMRSDHLtkHARRHL zf-C2H2 X +PRKCI PKCI P41743 human EZH2 2146 Q15910 EZH2 human T345 4957354 LtAERIKtPPkRPGG X 45153 +PRKCI PKCI P41743 human NRF2 4780 Q16236 NFE2L2 human S40 450082 SREVFDFsQRRkEYE X +PRKCI PKCI P41743 human Vimentin 7431 P08670 VIM human S56 451514 srsLyAssPGGVyAt Filament_head X 3877; 7391 +Prkcg PKCG P63319 rat GluR4 29629 P19493 Gria4 rat S862 448810 TRNKARLsITGSVGE X +Prkcg PKCG P63319 rat NMDAR1 24408 P35439 Grin1 rat S890 447737 ITSTLAssFKRRRss X +Prkcg PKCG P63319 rat Kv3.1 25327 P25122 Kcnc1 rat S503 464642 LEINRADsKLNGEVA X +Prkcg PKCG P63319 rat DGKG 25666 P49620 Dgkg rat S779 471078 PQKSsFFsLRRKSRS X +Prkcg PKCG P63319 rat DGKG 25666 P49620 Dgkg rat S776 471077 MGPPQKSsFFsLRRK X +ZAP70 ZAP70 P43403 human LAT iso2 27040 O43561-2 LAT human Y226 448006 EEEGAPDyENLQELN LAT X X 54364; 45170 +ZAP70 ZAP70 P43403 human GAB2 9846 Q9UQC2 GAB2 human Y614 449788 KSTGsVDyLALDFQP X +ZAP70 ZAP70 P43403 human ZAP70 7535 P43403 ZAP70 human Y315 448867 MPMDtsVyEsPysDP X +ZAP70 ZAP70 P43403 human SHC1 iso2 6464 P29353-2 SHC1 human Y239 448509 EEPPDHQyyNDFPGK X X +ZAP70 ZAP70 P43403 human DBNL 28988 Q9UJU6 DBNL human Y334 450090 QAEEEAVyEEPPEQE X X +ZAP70 ZAP70 P43403 human AGO2 27161 Q9UKV8 AGO2 human Y529 17533104 LPGKtPVyAEVkRVG Piwi X +ZAP70 ZAP70 P43403 human P38A 26416 P47811 Mapk14 mouse Y323 455799 DEPVADPyDQSFESR X +ZAP70 ZAP70 P43403 human LAT iso2 27040 O43561-2 LAT human Y171 448004 SMESIDDyVNVPESG LAT X X +ZAP70 ZAP70 P43403 human PLCG1 25738 P10686 Plcg1 rat Y1253 448576 EGsFEARyQQPFEDF X +ZAP70 ZAP70 P43403 human LNK 16923 O09039 Sh2b3 mouse Y536 476934 LRAIDNQyTPLSQLC X +ZAP70 ZAP70 P43403 human ZAP70 7535 P43403 ZAP70 human Y319 447587 tsVyEsPysDPEELk X 2701; 2717; 14791; 73382; 82975; 31754 +ZAP70 ZAP70 P43403 human LAT iso2 27040 O43561-2 LAT human Y132 447760 DDyHNPGyLVVLPDS LAT X X +ZAP70 ZAP70 P43403 human SHC1 iso2 6464 P29353-2 SHC1 human Y240 448510 EPPDHQyyNDFPGKE X X +ZAP70 ZAP70 P43403 human DBNL 28988 Q9UJU6 DBNL human Y344 450091 PPEQETFyEQPPLVQ X X +ZAP70 ZAP70 P43403 human THEMIS 387357 Q8N1K5 THEMIS human Y429 27806312 EAALLPLyMEGGFVE CABIT X +ZAP70 ZAP70 P43403 human DUSP3 1845 P51452 DUSP3 human Y38 459626 NEVTPRIyVGNASVA DSPc X X +ZAP70 ZAP70 P43403 human THEMIS 387357 Q8N1K5 THEMIS human Y540 27806313 EEITEEQyyMMRRYE X X +ZAP70 ZAP70 P43403 human THEMIS 387357 Q8N1K5 THEMIS human Y95 27806315 IVADkTPyLTMEEIT CABIT X +ZAP70 ZAP70 P43403 human SLP76 3937 Q13094 LCP2 human Y128 448219 DGEDDGDyEsPNEEE X X +ZAP70 ZAP70 P43403 human SHC1 iso2 6464 P29353-2 SHC1 human Y317 448511 ELFDDPSyVNVQNLD X +ZAP70 ZAP70 P43403 human ZAP70 7535 P43403 ZAP70 human Y493 447505 LGADDsyytARsAGk PK_Tyr_Ser-Thr X X 2704 +ZAP70 ZAP70 P43403 human SLP76 3937 Q13094 LCP2 human Y145 448220 PVEDDADyEPPPSND X X 14770; 16796 +ZAP70 ZAP70 P43403 human LAT iso2 27040 O43561-2 LAT human Y191 448005 SLDGSREyVNVSQEL LAT X X 20172 +ZAP70 ZAP70 P43403 human PLCG1 25738 P10686 Plcg1 rat Y783 447667 EGRNPGFyVEANPMP X 2821; 14461; 14008; 25678; 88717 +ZAP70 ZAP70 P43403 human THEMIS 387357 Q8N1K5 THEMIS human Y541 27806310 EITEEQyyMMRRYES X X +ZAP70 ZAP70 P43403 human P38A 1432 Q16539 MAPK14 human Y323 455799 DEPVADPyDQsFESR X X +ZAP70 ZAP70 P43403 human ZAP70 7535 P43403 ZAP70 human Y598 464392 QRMRACyysLASkVE X +ZAP70 ZAP70 P43403 human ZAP70 7535 P43403 ZAP70 human Y492 447504 ALGADDsyytARsAG PK_Tyr_Ser-Thr X X +ZAP70 ZAP70 P43403 human THEMIS 387357 Q8N1K5 THEMIS human Y174 27806311 LsQEGEFyECEDERI CABIT X +ZAP70 ZAP70 P43403 human ZAP70 7535 P43403 ZAP70 human Y597 464391 EQRMRACyysLASkV X +ZAP70 ZAP70 P43403 human DUSP3 1845 P51452 DUSP3 human Y138 448718 SPTLVIAyLMMRQKM DSPc X X +ZAP70 ZAP70 P43403 human Tau iso8 4137 P10636-8 MAPT human Y29 4103318 DRKDQGGytMHQDQE X +ZAP70 ZAP70 P43403 human LAT iso2 27040 O43561-2 LAT human Y127 448003 ADEDEDDyHNPGyLV LAT X +ZAP70 ZAP70 P43403 human Tau iso8 4137 P10636-8 MAPT human Y197 464351 KsGDRsGyssPGsPG X X +ZAP70 ZAP70 P43403 human ZAP70 7535 P43403 ZAP70 human Y126 447589 RDAMVRDyVRQTWkL X +ZAP70 ZAP70 P43403 human ZAP70 7535 P43403 ZAP70 human Y292 447586 DtLNsDGytPEPARI X +ZAP70 ZAP70 P43403 human SLP76 3937 Q13094 LCP2 human Y113 448218 ssFEEDDyESPNDDQ X X +ZAP70 ZAP70 P43403 human THEMIS 387357 Q8N1K5 THEMIS human Y353 27806314 PREFPTAyDLEIAkS CABIT X +BCR Bcr P11274 human 14-3-3 theta 10971 P27348 YWHAQ human S232 456053 LTLWtsDsAGEECDA X +BCR Bcr P11274 human 14-3-3 zeta 7534 P63104 YWHAZ human T232 449846 LTLWtsDtQGDEAEA X +BCR Bcr P11274 human Afadin 4301 P55196 AFDN human T909 6208300 VVTVAENtADELARS X +GSK3A GSK3A A6QLB8 cow Tau iso8 4137 P10636-8 MAPT human T231 449079 KKVAVVRtPPKsPss X 20473; 71429 +GSK3A GSK3A A6QLB8 cow Tau iso2 4137 P10636-2 MAPT human S315 449082 PVVSGDTsPRHLsNV X 35834; 20194; 98523; 91600; 49562 +GSK3A GSK3A A6QLB8 cow Tau iso6 4137 P10636-6 MAPT human S346 449082 PVVSGDTsPRHLSNV X 35834; 20194; 98523; 91600; 49562 +GSK3A GSK3A A6QLB8 cow Tau iso5 4137 P10636-5 MAPT human S325 449104 RVQSKIGsLDNITHV Tubulin-binding X +GSK3A GSK3A A6QLB8 cow Tau iso6 4137 P10636-6 MAPT human T173 449079 KKVAVVRtPPKsPSS X 20473; 71429 +GSK3A GSK3A A6QLB8 cow Tau iso8 4137 P10636-8 MAPT human S396 449081 GAEIVyKsPVVsGDt X 9632 +GSK3A GSK3A A6QLB8 cow Tau iso5 4137 P10636-5 MAPT human T181 447932 KTPPAPKtPPsSGEP X 12885; 66224; 62672 +GSK3A GSK3A A6QLB8 cow Tau iso8 4137 P10636-8 MAPT human S404 449082 PVVsGDtsPRHLsNV X 35834; 20194; 98523; 91600; 49562 +GSK3A GSK3A A6QLB8 cow Tau iso5 4137 P10636-5 MAPT human S195 450221 PPKSGDRsGYssPGs X +GSK3A GSK3A A6QLB8 cow Tau iso5 4137 P10636-5 MAPT human S262 447930 NVKSKIGsTENLKHQ Tubulin-binding X +GSK3A GSK3A A6QLB8 cow Tau iso5 4137 P10636-5 MAPT human T231 449079 KKVAVVRtPPKsPSS X 20473; 71429 +GSK3A GSK3A A6QLB8 cow Tau iso5 4137 P10636-5 MAPT human S198 449551 SGDRsGYssPGsPGt X +GSK3A GSK3A A6QLB8 cow Tau iso5 4137 P10636-5 MAPT human S365 449081 GAEIVYKsPVVsGDT X 9632 +GSK3A GSK3A A6QLB8 cow Tau iso2 4137 P10636-2 MAPT human S307 449081 GAEIVYKsPVVSGDT X 9632 +GSK3A GSK3A A6QLB8 cow Tau iso5 4137 P10636-5 MAPT human S369 449130 VYKsPVVsGDTsPRH X 35834; 20194; 98523; 91600; 49562 +GSK3A GSK3A A6QLB8 cow Tau iso5 4137 P10636-5 MAPT human T205 447933 ssPGsPGtPGSRSRT X 25377; 43964; 53001; 49561; 20060; 33032; 30505; 20739; 98160 +GSK3A GSK3A A6QLB8 cow Tau iso5 4137 P10636-5 MAPT human S184 452062 PAPKtPPsSGEPPKS X +GSK3A GSK3A A6QLB8 cow Tau iso5 4137 P10636-5 MAPT human S373 449082 PVVsGDTsPRHLSNV X 35834; 20194; 98523; 91600; 49562 +GSK3A GSK3A A6QLB8 cow Tau iso6 4137 P10636-6 MAPT human S338 449081 GAEIVYKsPVVSGDT X 9632 +GSK3A GSK3A A6QLB8 cow Tau iso6 4137 P10636-6 MAPT human S177 449080 VVRtPPKsPSSAKSR X 20473 +GSK3A GSK3A A6QLB8 cow Tau iso5 4137 P10636-5 MAPT human S202 447928 sGYssPGsPGtPGSR X 39357; 30505 +GSK3A GSK3A A6QLB8 cow Tau iso5 4137 P10636-5 MAPT human S199 447927 GDRsGYssPGsPGtP X 29957 +GSK3A GSK3A A6QLB8 cow Tau iso5 4137 P10636-5 MAPT human S235 449080 VVRtPPKsPSSAKSR X 20473 +GSK3A GSK3A A6QLB8 cow Tau iso8 4137 P10636-8 MAPT human S235 449080 VVRtPPKsPssAKsR X 20473 +PKMYT1 Myt1 Q99640 human CDK1 54237 P39951 Cdk1 rat Y15 447610 EKIGEGtyGVVyKGR Pkinase X 4539; 9111; 14566; 77897 +PKMYT1 Myt1 Q99640 human CDK1 983 P06493 CDK1 human T14 447608 IEkIGEGtyGVVykG Pkinase X X 2543 +PKMYT1 Myt1 Q99640 human CDK1 983 P06493 CDK1 human Y15 447610 EkIGEGtyGVVykGR Pkinase X X 4539; 9111; 14566; 77897 +NEK7 NEK7 Q8TDX7 human KIF14 9928 Q15058 KIF14 human S1220 114810404 NLHSsHssGLMDkSS X +NEK7 NEK7 Q8TDX7 human KIF14 9928 Q15058 KIF14 human S607 114810406 NLIDLAGsERCSTAH Kinesin X +NEK7 NEK7 Q8TDX7 human KIF11 3832 P52732 KIF11 human S1033 20798600 GINtLERskVEETTE Microtub_bind X +NEK7 NEK7 Q8TDX7 human KIF14 9928 Q15058 KIF14 human S1219 114810407 KNLHSsHssGLMDkS X +NEK7 NEK7 Q8TDX7 human KIF14 9928 Q15058 KIF14 human S56 31882103 NDDPLLRsAGKVRDI X +NEK7 NEK7 Q8TDX7 human TRF1 7013 P54274 TERF1 human S114 63083903 AIIHGLSsLTACQLR TRF X +NEK7 NEK7 Q8TDX7 human KIF14 9928 Q15058 KIF14 human S1217 114810405 PIKNLHSsHssGLMD X +Stk3 MST2 O54748 rat MST2 65189 O54748 Stk3 rat T180 448899 DTMAKRNtVIGTPFW Pkinase X 3681; 49332 +MAP2K2 MEK2 Q90891 chicken BMAL1 374115 Q9I8T7 BMAL1 chicken T534 448633 SPLNITStPPPDTSS X X +Lrrk1 LRRK1 Q3UHC2 mouse Rab7 19349 P51150 Rab7a mouse S72 468547 AGQERFQsLGVAFYR Ras X +GAK GAK O14976 human p63 8626 Q9H3D4 TP63 human T46 912008301 TMSQsTQtNEFLsPE X +GAK GAK O14976 human CLTC 1213 Q00610 CLTC human T606 1868832801 ILGNQMFtHYDRAHI Clathrin X X +GAK GAK O14976 human p63 8626 Q9H3D4 TP63 human T281 912008300 QYVEDPItGRQSVLV P53 X +DYRK3 DYRK3 O43781 human H3F3A 3020 P84243 H3-3A human T45 18545304 PHryrPGtVALrEIR Histone X +DYRK3 DYRK3 O43781 human PRAS40 84335 Q96B36 AKT1S1 human T246 470067 LPRPRLNtsDFQkLK PRAS X X 2640; 2997; 32263; 13175; 60202 +DYRK3 DYRK3 O43781 human SIRT1 93759 Q923E4 Sirt1 mouse T522 6006905 HLSELPPtPLHIsED X X +DYRK3 DYRK3 O43781 human SRC-3 8202 Q9Y6Q9 NCOA3 human S1330 3217872 PAFGRVSsPPNAMMS DUF1518 X X +CSNK2A1 CK2A1 P68399 cow DARPP-32 360616 Q6J4I0 Ppp1r1b rat S45 465607 LFRVSEHssPEEESS DARPP-32 X +CSNK2A1 CK2A1 P68399 cow Tau iso8 4137 P10636-8 MAPT human T39 451639 HQDQEGDtDAGLkEs X +CSNK2A1 CK2A1 P68399 cow DARPP-32 282459 P07516 PPP1R1B cow S45 465607 LFRLsEHsSPEEEAS DARPP-32 X +CSNK2A1 CK2A1 P68399 cow NFL 281348 P02548 NEFL cow S473 450895 EAKDEPPsEGEAEEE X +CSNK2A1 CK2A1 P68399 cow DARPP-32 282459 P07516 PPP1R1B cow S42 465608 PAMLFRLsEHsSPEE DARPP-32 X +CSNK2A1 CK2A1 P68399 cow adrenodoxin 281157 P00257 FDX1 cow T129 455475 FEKLEAItDEENDML Fer2 X +CSNK2A1 CK2A1 P68399 cow PKAR2A 518399 P00515 PRKAR2A cow S77 456583 DAVADsEsEDEEDLD X +CSNK2A1 CK2A1 P68399 cow Calmodulin 24242 P0DP29 Calm3 rat T118 469586 TNLGEkLtDEEVDEM EF-hand_7 X +CSNK2A1 CK2A1 P68399 cow Calmodulin 24242 P0DP29 Calm3 rat S102 448706 kDGNGyIsAAELRHV EF-hand_7 X +CSNK2A1 CK2A1 P68399 cow PKAR2A 518399 P00515 PRKAR2A cow S75 4702645 VADAVADsEsEDEED X +CSNK2A1 CK2A1 P68399 cow SYT1 281511 P48018 SYT1 cow T129 451522 DDAETGLtDGEEKEE X +CSNK2A1 CK2A1 P68399 cow Calmodulin 24242 P0DP29 Calm3 rat T80 448704 MARKMkDtDsEEEIR X +CSNK2A1 CK2A1 P68399 cow DARPP-32 282459 P07516 PPP1R1B cow S102 457675 NLGENQAsEEEDELG DARPP-32 X +CSNK2A1 CK2A1 P68399 cow Calmodulin 24242 P0DP29 Calm3 rat S82 448705 RKMkDtDsEEEIREA X +CSNK2A1 CK2A1 P68399 cow DARPP-32 360616 Q6J4I0 Ppp1r1b rat S102 457675 NLsENQAsEEEDELG DARPP-32 X 3401 +CSNK2A1 CK2A1 P68399 cow VDR 7421 P11473 VDR human S208 456982 SFSNLDLsEEDSDDP X +TXK TXK P42681 human TXK 7294 P42681 TXK human Y420 460526 RYVLDDEyVSSFGAK PK_Tyr_Ser-Thr X +TXK TXK P42681 human TXK 7294 P42681 TXK human Y91 2861416 KIQVKALyDFLPREP SH3_1 X +BMPR1B BMPR1B O00238 human SMAD1 4086 Q15797 SMAD1 human S465 448363 HNPIssVs_______ X X 9516; 9576; 12428; 11971; 67959; 13820; 85553; 52937 +BMPR1B BMPR1B O00238 human SMAD2 4087 Q15796 SMAD2 human S467 447495 sVRCssMs_______ X 3108; 8828; 11979; 26945; 55041; 68550; 18338; 56532; 67804 +BMPR1B BMPR1B O00238 human SMAD1 4086 Q15797 SMAD1 human S462 448361 GsPHNPIssVs____ X X +BMPR1B BMPR1B O00238 human SMAD2 4087 Q15796 SMAD2 human S465 447494 sPsVRCssMs_____ X 3108; 8828; 11979; 26945; 55041; 68550; 18338; 56532; 67804 +BMPR1B BMPR1B O00238 human SMAD1 4086 Q15797 SMAD1 human S463 448362 sPHNPIssVs_____ X X 9516; 9576; 12428; 11971; 67959; 13820; 85553; 52937 +BMPR1B BMPR1B O00238 human SMAD2 4087 Q15796 SMAD2 human S464 447567 GsPsVRCssMs____ X +Prkce PKCE P16054 mouse PRKD1 18760 Q62101 Prkd1 mouse S744 448589 ARIIGEksFRRsVVG Pkinase X X 2054 +Prkce PKCE P16054 mouse PRKD1 85421 Q9WTQ1 Prkd1 rat S748 448590 GEKsFRRsVVGTPAY Pkinase X +Prkce PKCE P16054 mouse Akt1 24185 P47196 Akt1 rat S473 447855 RPHFPQFsYSASGTA Pkinase_C X 9271; 3787; 4060; 4051; 5102; 4058; 2336; 2337; 4075; 4070; 5012; 4071; 92982; 5315; 9563; 9018; 12694; 52240; 11962; 15116; 88106; 26580; 68035; 31957; 23430; 20235 +Prkce PKCE P16054 mouse RIP140 268903 Q8CBD1 Nrip1 mouse S102 3345202 AAKRKRLsDsIVNLN NRIP1_repr_1 X +Prkce PKCE P16054 mouse FBXW7 55294 Q969H0 FBXW7 human S10 17337000 QELLSVGsKRRRTGG X +Prkce PKCE P16054 mouse FBXW7 55294 Q969H0 FBXW7 human S18 17337001 KRRRTGGsLRGNPSs X +Prkce PKCE P16054 mouse TNNI3 21954 P48787 Tnni3 mouse S24 448424 APVRRRssANyRAYA Troponin-I_N X +Prkce PKCE P16054 mouse PKCD 170538 P09215 Prkcd rat T505 447511 FGENRAstFCGTPDy Pkinase X 9379; 9374; 2060; 38938; 93292 +Prkce PKCE P16054 mouse STAT3 20848 P42227 Stat3 mouse S727 448191 NtIDLPMsPRTLDSL X X 9134; 9136; 34911; 94994; 49081; 58978; 87544; 71958; 50804 +Prkce PKCE P16054 mouse NSF 18195 P46460 Nsf mouse S460 15794301 MNRHIKAstkVEVDM AAA_lid_3 X +Prkce PKCE P16054 mouse PRKD1 18760 Q62101 Prkd1 mouse S748 448590 GEksFRRsVVGtPAy Pkinase X X 2054 +Prkce PKCE P16054 mouse RIP140 268903 Q8CBD1 Nrip1 mouse S1003 455634 VTDHRTFsYPGMVKT NRIP1_repr_4 X +Prkce PKCE P16054 mouse ITGB1 16412 P09055 Itgb1 mouse T788 448600 PIyksAVttVVNPky Integrin_b_cyt X +Prkce PKCE P16054 mouse PRKD1 85421 Q9WTQ1 Prkd1 rat S744 448589 ARIIGEKsFRRsVVG Pkinase X +Prkce PKCE P16054 mouse TRAF2 22030 P39429 Traf2 mouse T117 471341 DGCTWKGtLKEYESC X X +Prkce PKCE P16054 mouse TNNI3 21954 P48787 Tnni3 mouse S23 448423 PAPVRRRssANyRAY Troponin-I_N X +Prkce PKCE P16054 mouse ITGB1 16412 P09055 Itgb1 mouse T789 447709 IyksAVttVVNPkyE Integrin_b_cyt X +Prkce PKCE P16054 mouse MYBPC3 17868 O70468 Mybpc3 mouse S302 471081 sLLKKRDsFRRDskL X X +Prkce PKCE P16054 mouse GABRG2 14406 P22723 Gabrg2 mouse S365 486436 FVSNRkPskDkDkkk Neur_chan_memb X +Prkce PKCE P16054 mouse Akt1 24185 P47196 Akt1 rat T308 447856 KDGATMKtFCGTPEy Pkinase X 5106; 2965; 9275; 4056; 5056; 13842; 13038; 43506; 48646; 86758; 80722; 77440; 80556 +Prkce PKCE P16054 mouse MYBPC3 17868 O70468 Mybpc3 mouse S273 471079 RsAFRRtsLAGAGRR X X +Pik3cd PIK3CD O35904 mouse Btk 12229 P35991 Btk mouse Y551 447486 RYVLDDEyTsSVGSK PK_Tyr_Ser-Thr X 69360; 18805; 64137; 16803 +Pik3cd PIK3CD O35904 mouse Btk 12229 P35991 Btk mouse Y223 447485 LKKVVALyDyMPMNA SH3_1 X 5082; 87141; 87457 +TYK2 Tyk2 P29597 human Tyk2 7297 P29597 TYK2 human Y292 450907 QAEGEPCyIRDSGVA Jak1_Phl X +TYK2 Tyk2 P29597 human GJA1 24392 P08050 Gja1 rat Y313 454254 sEQNWANysAEQNRM Connexin43 X +TYK2 Tyk2 P29597 human GJA1 24392 P08050 Gja1 rat Y265 447815 kDCGsPkyAyFNGCS X X +TYK2 Tyk2 P29597 human KLF10 21847 O89091 Klf10 mouse Y179 18958500 KAASILNyQDNSFRR X +TYK2 Tyk2 P29597 human Tyk2 7297 P29597 TYK2 human Y1054 447499 AVPEGHEyyRVREDG PK_Tyr_Ser-Thr X 9321; 68790; 32901 +TYK2 Tyk2 P29597 human LATS1 16798 Q8BYR2 Lats1 mouse Y200 1876860400 SLGENVVyRSEsPNs X X +TYK2 Tyk2 P29597 human Tyk2 7297 P29597 TYK2 human Y1055 447503 VPEGHEyyRVREDGD PK_Tyr_Ser-Thr X 9321; 68790; 32901 +TYK2 Tyk2 P29597 human Siva 10572 O15304 SIVA1 human Y53 15329000 LFLGAQAyLDHVWDE Siva X +TYK2 Tyk2 P29597 human IFNAR1 3454 P17181 IFNAR1 human Y466 450029 VFLRCINyVFFPSLK X +TYK2 Tyk2 P29597 human RACK1 10399 P63244 RACK1 human Y194 452182 NHIGHtGyLNTVTVS WD40 X +TYK2 Tyk2 P29597 human GJA1 24392 P08050 Gja1 rat Y267 465295 CGsPkyAyFNGCSSP X +TYK2 Tyk2 P29597 human IFNAR1 3454 P17181 IFNAR1 human Y481 2091900 PSSSIDEyFSEQPLK X +TYK2 Tyk2 P29597 human Siva 10572 O15304 SIVA1 human Y162 15329001 LVDCSDMyEKVLCTS Siva X +TYK2 Tyk2 P29597 human STAT3 6774 P40763 STAT3 human Y640 386186603 QIQsVEPytkQQLNN SH2 X +TYK2 Tyk2 P29597 human GJA1 24392 P08050 Gja1 rat Y247 447814 VKGRsDPyHATTGPL X X +TYK2 Tyk2 P29597 human LATS1 16798 Q8BYR2 Lats1 mouse Y277 484657 PSSQTKRysGNMEYV X X +TYK2 Tyk2 P29597 human STAT1 6772 P42224 STAT1 human Y701 447754 DGPkGtGyIktELIs X X 9174; 9167; 5375; 25685; 8062; 8183; 8009; 55603; 7649; 25809; 57216; 45118; 39205; 88845; 88211; 76285; 90145 +PTK2B Pyk2 Q14289 human Hic-5 7041 O43294 TGFB1I1 human Y60 450964 SGDKDHLystVCKPR Paxillin X +PTK2B Pyk2 Q14289 human ID3 3399 Q02535 ID3 human Y48 35524904 LDDMNHCySRLRELV HLH X X +PTK2B Pyk2 Q14289 human Cortactin 2017 Q14247 CTTN human Y470 447703 AyATEAVyESAEAPG X X +PTK2B Pyk2 Q14289 human ID3 3399 Q02535 ID3 human S18 25295708 yEAVCCLsERsLAIA X +PTK2B Pyk2 Q14289 human ID3 3399 Q02535 ID3 human S5 451011 ___MkALsPVRGCyE X X +PTK2B Pyk2 Q14289 human NPHP1 4867 O15259 NPHP1 human Y46 18449508 PNKRQHIyQRCIQLK X +PTK2B Pyk2 Q14289 human eNOS 397557 Q7YSG7 NOS3 pig Y659 2811400 FGLGSRAyPHFCAFA Flavodoxin_1 X +PTK2B Pyk2 Q14289 human DDEF1 13196 Q9QWY8 Asap1 mouse Y308 450437 PKEVGGLyVASRANS X +PTK2B Pyk2 Q14289 human LAT iso2 27040 O43561-2 LAT human Y171 448004 SMESIDDyVNVPESG LAT X +PTK2B Pyk2 Q14289 human eNOS 18127 P70313 Nos3 mouse Y656 2811400 FGLGSRAyPHFCAFA Flavodoxin_1 X +PTK2B Pyk2 Q14289 human SNCA 6622 P37840 SNCA human Y125 448279 VDPDNEAyEMPsEEG Synuclein X +PTK2B Pyk2 Q14289 human FAK 5747 Q05397 PTK2 human Y407 447888 IIDEEDtytMPSTRD X +PTK2B Pyk2 Q14289 human DDEF1 13196 Q9QWY8 Asap1 mouse Y782 450438 RDKQRLSyGAFTNQI X +PTK2B Pyk2 Q14289 human eNOS 4846 P29474 NOS3 human Y657 2811400 FGLGSRAyPHFCAFA Flavodoxin_1 X +PTK2B Pyk2 Q14289 human NPHP1 4867 O15259 NPHP1 human Y349 18449510 GNQFRANyFLQPELM X +PTK2B Pyk2 Q14289 human ATG3 67841 Q9CPX6 Atg3 mouse Y203 62940500 QTRTYDLyITYDkYY Autophagy_act_C X +PTK2B Pyk2 Q14289 human Cortactin 2017 Q14247 CTTN human Y486 447704 yPAEDStyDEYENDL X X +PTK2B Pyk2 Q14289 human ID3 3399 Q02535 ID3 human Y11 15411043 LsPVRGCyEAVCCLs X X +PTK2B Pyk2 Q14289 human Cortactin 2017 Q14247 CTTN human Y421 447702 rLPssPVyEDAAsFK X X 4569 +PTK2B Pyk2 Q14289 human Pyk2 19229 Q9QVP9 Ptk2b mouse Y402 447955 CSIESDIyAEIPDET X 3291 +PTK2B Pyk2 Q14289 human Pyk2 2185 Q14289 PTK2B human Y402 447955 CsIEsDIyAEIPDEt X 3291 +PTK2B Pyk2 Q14289 human STIM1 6786 Q13586 STIM1 human Y361 25755095 THEVEVQyYNIKKQN SOAR X +RPS6KB2 P70S6KB Q9UBS0 human EEF2K 29904 O00418 EEF2K human S366 447827 sPQVRtLsGSRPPLL X 3691 +RPS6KB2 P70S6KB Q9UBS0 human HSP27 3315 P04792 HSPB1 human S82 448403 RALsRQLssGVsEIr X 2406; 2401; 9709; 11892; 64293 +RPS6KB2 P70S6KB Q9UBS0 human TRBP 6895 Q15633 TARBP2 human S283 27457469 ILSLRsCsLGsLGAL X +RPS6KB2 P70S6KB Q9UBS0 human HSP27 3315 P04792 HSPB1 human S78 448402 PAysRALsRQLssGV X 2405 +RPS6KB2 P70S6KB Q9UBS0 human GSK3B 2932 P49841 GSK3B human S9 449111 SGRPRttsFAEsCkP X 9336; 9331; 9327; 9323; 9322; 9325; 5558; 8566; 79774; 8466; 25462; 14026; 14332; 14310; 14630 +RPS6KB2 P70S6KB Q9UBS0 human K18 3875 P05783 KRT18 human S53 447734 IsVsrstsFrGGMGs X +RPS6KB2 P70S6KB Q9UBS0 human hnRNP A1 3178 P09651 HNRNPA1 human S4 468002 ____MsksEsPkEPE X X +RPS6KB2 P70S6KB Q9UBS0 human hnRNP A1 3178 P09651 HNRNPA1 human S6 455946 __MsksEsPkEPEQL X X +RPS6KB2 P70S6KB Q9UBS0 human RICTOR 253260 Q6R327 RICTOR human T1135 458276 NRRIRtLtEPsVDFN RICTOR_phospho X 3806 +FGR FGR P09769 human FAK 5747 Q05397 PTK2 human Y925 447966 DRsNDkVyENVtGLV Focal_AT X 3284 +FGR FGR P09769 human ACO2 79250 Q9ER34 Aco2 rat Y544 1458607 FDPGQDTyQHPPkDS X +FGR FGR P09769 human 5-LO 240 P09917 ALOX5 human Y446 33670311 RAMKDLtyAsLCFPE Lipoxygenase X +FGR FGR P09769 human TBK1 29110 Q9UHD2 TBK1 human Y354 3437786 SSNQELIyEGRRLVL TBK1_ULD X +FGR FGR P09769 human GLO1 2739 Q04760 GLO1 human Y136 463450 GIAVPDVysACkRFE Glyoxalase X +FGR FGR P09769 human SDHA Q920L2 Sdha rat Y596 1458603 YkVRIDEyDYSkPIE Succ_DH_flav_C X +FGR FGR P09769 human SDHA Q920L2 Sdha rat Y535 1458604 CEkVSQLyGDLQHLk Succ_DH_flav_C X +FGR FGR P09769 human NRF2 4780 Q16236 NFE2L2 human Y576 460703 RDEDGkPysPSEYSL X +FGR FGR P09769 human FAK 5747 Q05397 PTK2 human Y397 447887 sVsEtDDyAEIIDEE X 3283; 8556 +FGR FGR P09769 human RIPK2 8767 O43353 RIPK2 human Y474 4270705 DLIMKEDyELVSTkP CARD X X +FGR FGR P09769 human 5-LO 240 P09917 ALOX5 human Y54 33670310 ERGAVDSyDVTVDEE PLAT X +FGR FGR P09769 human FAK 5747 Q05397 PTK2 human Y576 447889 RyMEDstyyKAsKGK PK_Tyr_Ser-Thr X 3281 +FGR FGR P09769 human TBK1 29110 Q9UHD2 TBK1 human Y394 126839800 LNTIGLIyEkISLPk TBK1_ULD X +FGR FGR P09769 human 5-LO 240 P09917 ALOX5 human Y43 33670312 HLLDKPFyNDFERGA PLAT X +FGR FGR P09769 human ACO2 79250 Q9ER34 Aco2 rat Y665 1458606 VVIGDENyGEGsSRE Aconitase_C X +FGR FGR P09769 human IKKG 8517 Q9Y6K9 IKBKG human Y374 473650 PLPPAPAyLssPLAL X +FGR FGR P09769 human ACO2 79250 Q9ER34 Aco2 rat Y71 1458605 TLSEkIVyGHLDDPA Aconitase X +Uhmk1 KIS P97343 mouse STMN1 3925 P16949 STMN1 human S38 448556 sVPEFPLsPPkKkDL Stathmin X 3426; 4191 +Rps6ka1 p90RSK P18653 mouse TTP 22695 P22893 Zfp36 mouse S316 451153 LPIFNRIsVsE____ X X +Rps6ka1 p90RSK P18653 mouse C/EBP-beta 12608 P28033 Cebpb mouse T217 448447 AkAKAkktVDKLsDE X X +Rps6ka1 p90RSK P18653 mouse GAB2 14389 Q9Z1S8 Gab2 mouse S620 15410336 PsPHRKPstSsVtsD X +Rps6ka1 p90RSK P18653 mouse SRF 6722 P11831 SRF human S103 447692 RGLKRsLsEMEIGMV X 4261 +Rps6ka1 p90RSK P18653 mouse CASP8 12370 O89110 Casp8 mouse T265 21258500 KMKDRKGtDCDKEAL Peptidase_C14 X X +Rps6ka1 p90RSK P18653 mouse BAD 12015 Q61337 Bad mouse S112 447860 ETRsRHssyPAGtEE Bcl-2_BAD X X 9291; 5284; 9296; 5193; 11865; 94223 +Rps6ka1 p90RSK P18653 mouse LKB1 20869 Q9WTK7 Stk11 mouse S431 448147 sNKIRRLsACKQQ__ X X 3482 +Rps6ka1 p90RSK P18653 mouse TNNI3 21954 P48787 Tnni3 mouse S24 448424 APVRRRssANyRAYA Troponin-I_N X X +Rps6ka1 p90RSK P18653 mouse MITF iso8 17342 Q08874-8 Mitf mouse S409 450265 KTSSRRSsMSAEETE DUF3371 X +Rps6ka1 p90RSK P18653 mouse FLNA 192176 Q8BTM8 Flna mouse S2152 451357 TRRRRAPsVANIGsH Filamin X 4761 +Rps6ka1 p90RSK P18653 mouse BAD 12015 Q61337 Bad mouse S155 447863 GRELRRMsDEFEGsF Bcl-2_BAD X 9297 +Rps6ka1 p90RSK P18653 mouse ERK5 23939 Q9WVS8 Mapk7 mouse S496 455518 SRLRDGPsAPLEAPE X +Rps6ka1 p90RSK P18653 mouse GAB2 14389 Q9Z1S8 Gab2 mouse S160 448382 LLRERKSsAPSHSsQ X 3884 +Rps6ka1 p90RSK P18653 mouse K17 16667 Q9QWL7 Krt17 mouse S44 464291 AGsCRLGsASGLGSA X +Rps6ka1 p90RSK P18653 mouse H3 iso3 15081 P84244 H3f3b mouse S10 455676 tKQTARksTGGkAPR Histone X 9701; 9711; 9706; 3465; 3642; 3377; 3475; 3458; 5764; 47398; 8481; 8552; 53348; 29237; 66065; 43185; 64522; 52725 +Rps6ka1 p90RSK P18653 mouse TNNI3 21954 P48787 Tnni3 mouse S23 448423 PAPVRRRssANyRAY Troponin-I_N X X +Rps6ka1 p90RSK P18653 mouse MYBPC3 295929 P56741 Mybpc3 rat S288 471080 AGTGRRtsDSHEDAG X +Rps6ka1 p90RSK P18653 mouse HMGN1 15312 P18608 Hmgn1 mouse S7 465531 _MPKRKVsADGAAkA HMG14_17 X +Rps6ka1 p90RSK P18653 mouse CREB 12912 Q01147 Creb1 mouse S119 448228 EILsRRPsyRkILND pKID X 9187; 9196; 9198; 4095; 14228; 14001; 39561; 80120; 44864; 54960; 95995 +Rps6ka1 p90RSK P18653 mouse GAB2 14389 Q9Z1S8 Gab2 mouse S211 4825112 TENARSAsFSQGTRQ X +Stk26 MST4 Q99JT2 mouse TRAF6 22034 P70196 Traf6 mouse T494 34362608 LEALRQGtFIKDDTL X +Stk26 MST4 Q99JT2 mouse TRAF6 22034 P70196 Traf6 mouse T471 40240800 LLAFQRPtIPRNPKG X +Eif2ak1 HRI Q9Z2R9 mouse HRI 15467 Q9Z2R9 Eif2ak1 mouse T485 447595 GKGTRtHtSRVGtCL Pkinase X +Eif2ak1 HRI Q9Z2R9 mouse HRI 15467 Q9Z2R9 Eif2ak1 mouse T483 449629 RNGKGTRtHtSRVGt Pkinase X +Aurka AurA P97477 mouse KIFAP3 16579 P70188 Kifap3 mouse S102 18260847 YLQNRRDsLPGKEKK KAP X +Aurka AurA P97477 mouse AurA 6790 O14965 AURKA human T288 448784 APSsRRttLCGtLDy Pkinase X 3079; 2914; 13464; 8525 +Aurka AurA P97477 mouse CDC25B 12531 P30306 Cdc25b mouse S351 452008 VQSKRRKsVtPLEEQ M-inducer_phosp X +Aurka AurA P97477 mouse CPEB 12877 P70166 Cpeb1 mouse T171 449610 VRGSRLDtRPILDsR CEBP1_N X X +Aurka AurA P97477 mouse PLK1 18817 Q07832 Plk1 mouse T210 448139 YEGERKKtLCGtPNY Pkinase X 4354; 5472 +Prkaa1 AMPKA1 P54645 rat p27Kip1 12576 P46414 Cdkn1b mouse T170 6058800 QNkRANRtEENVsDG X +Prkaa1 AMPKA1 P54645 rat AMPKB1 83803 P80386 Prkab1 rat S24 448111 HKTPRRDssGGTKDG X +Prkaa1 AMPKA1 P54645 rat ACC1 60581 P11497 Acaca rat S1215 449868 YGMTHVAsVSDVLLD ACC_central X +Prkaa1 AMPKA1 P54645 rat AMPKB1 83803 P80386 Prkab1 rat S96 450436 KEVYLSGsFNNWsKL AMPK1_CBM X +Prkaa1 AMPKA1 P54645 rat p27Kip1 12576 P46414 Cdkn1b mouse S83 451426 WQEVERGsLPEFyYR X +Prkaa1 AMPKA1 P54645 rat TNNI3 29248 P23693 Tnni3 rat S151 451822 tLRRVRIsADAMMQA Troponin X +Prkaa1 AMPKA1 P54645 rat AMPKA1 65248 P54645 Prkaa1 rat T183 448786 SDGEFLRtsCGSPNY Pkinase X X 2535; 2531; 4188; 5256; 50081; 74281 +Prkaa1 AMPKA1 P54645 rat SQSTM1 113894 O08623 Sqstm1 rat S293 31872178 SSCSSEVsKPDGAGE X +Prkaa1 AMPKA1 P54645 rat ACC1 60581 P11497 Acaca rat S79 448292 FHMRSsMsGLHLVKQ X X 3661; 11818; 42801 +Prkaa1 AMPKA1 P54645 rat HNF4 alpha 3172 P41235 HNF4A human S313 449926 GkIkRLRsQVQVsLE Hormone_recep X +Prkaa1 AMPKA1 P54645 rat AMPKB1 83803 P80386 Prkab1 rat S25 448112 KTPRRDssGGTKDGD X +Prkaa1 AMPKA1 P54645 rat eNOS 24600 Q62600 Nos3 rat S1176 447884 TSRIRtQsFsLQERQ X X 9570 +Prkaa1 AMPKA1 P54645 rat AMPKA1 65248 P54645 Prkaa1 rat S496 450431 AtPQRSGsISNYRSC AdenylateSensor X 4185; 4184; 2537 +Prkaa1 AMPKA1 P54645 rat DRP1 114114 O35303 Dnm1l rat S656 483971 VPVARKLsAREQRDC X 4867; 6319 +Prkaa1 AMPKA1 P54645 rat PFKFB3 5209 Q16875 PFKFB3 human S461 448801 NPLMRRNsVtPLAsP X +Prkaa1 AMPKA1 P54645 rat NKCC1 6558 P55011 SLC12A2 human S77 3192079 RPLGPtPsQsRFQVD X +Prkaa1 AMPKA1 P54645 rat PFKFB2 24640 Q9JJH5 Pfkfb2 rat S469 448460 PVRMRRNsFtPLSSS X X +Prkaa1 AMPKA1 P54645 rat AMPKA1 65248 P54645 Prkaa1 rat T269 450433 VDPMKRAtIKDIREH Pkinase X +Prkaa1 AMPKA1 P54645 rat ACC1 60581 P11497 Acaca rat S1200 448290 IPtLNRMsFASNLNH ACC_central X +Prkaa1 AMPKA1 P54645 rat AMPKB1 83803 P80386 Prkab1 rat S182 448110 DVSELSssPPGPYHQ X 4186 +Prkaa1 AMPKA1 P54645 rat AMPKB1 83803 P80386 Prkab1 rat S101 450435 SGsFNNWsKLPLTRs AMPK1_CBM X +Prkaa1 AMPKA1 P54645 rat TORC2 74343 Q3U182 Crtc2 mouse S171 454622 sALNRtSsDsALHTs TORC_M X +Prkaa1 AMPKA1 P54645 rat PDLIM5 56376 Q8CI51 Pdlim5 mouse S177 38546304 TPLHLSAsGLHVSAN X +Prkaa1 AMPKA1 P54645 rat Claudin-4 304407 Q5XIT8 Cldn4 rat S199 15425616 KPYsAKYsAARsVPA X X +Prkaa1 AMPKA1 P54645 rat IRS1 16367 P35569 Irs1 mouse S789 447557 QHLRLSSsSGRLRYT X 2389 +Prkaa1 AMPKA1 P54645 rat MDM4 4194 O15151 MDM4 human S342 470031 SkLTHSLsTSDITAI X +Prkaa1 AMPKA1 P54645 rat eNOS 24600 Q62600 Nos3 rat T494 447885 TGITRKKtFKEVANA X X +Prkaa1 AMPKA1 P54645 rat p27Kip1 12576 P46414 Cdkn1b mouse T197 448781 KPGLRRQt_______ X +Prkaa1 AMPKA1 P54645 rat AMPKB1 83803 P80386 Prkab1 rat S108 448522 sKLPLTRsQNNFVAI AMPK1_CBM X 23021 +Prkaa1 AMPKA1 P54645 rat GYS1 100008660 P13834 GYS1 rabbit S8 449898 MPLSRTLsVSsLPGL X +Pak2 PAK2 Q8CIN4 mouse Myc 17869 P01108 Myc mouse S388 450961 RRNELKRsFFALRDQ HLH X X +Pak2 PAK2 Q8CIN4 mouse Myc 17869 P01108 Myc mouse T373 450960 EENDKRRtHNVLERQ HLH X X +Pak2 PAK2 Q8CIN4 mouse Myc 17869 P01108 Myc mouse T415 450962 VVILKKAtAYILSIQ HLH X X +PTK6 Brk Q13882 human CTNNB1 1499 P35222 CTNNB1 human Y142 449044 AVVNLINyQDDAELA X +PTK6 Brk Q13882 human ETV4 2118 P43268 ETV4 human Y392 5231710 KNRPAMNyDKLSRSL Ets X +PTK6 Brk Q13882 human STAP2 55620 Q9UGK3 STAP2 human Y250 478353 PFLLDEDyEKVLGyV X +PTK6 Brk Q13882 human CENTD2 116985 Q96P48 ARAP1 human Y231 3209592 PEFDDsDyDEVPEEG X +PTK6 Brk Q13882 human P130Cas 9564 P56945 BCAR1 human Y165 448722 PSPATDLyQVPPGPG X X 4015 +PTK6 Brk Q13882 human CTNNB1 1499 P35222 CTNNB1 human Y331 471405 LVNIMRTytyEkLLW X +PTK6 Brk Q13882 human PXN iso2 5829 P49023-2 PXN human Y118 448604 VGEEEHVysFPNKQK Paxillin X 2541; 69363 +PTK6 Brk Q13882 human CTNNB1 1499 P35222 CTNNB1 human Y64 12170302 VDTsQVLyEWEQGFS X +PTK6 Brk Q13882 human PXN iso2 5829 P49023-2 PXN human Y31 448785 FLSEETPySyPTGNH X +PTK6 Brk Q13882 human ARHGAP5 394 Q13017 ARHGAP5 human Y1109 455068 kGysDEIyVVPDDsQ RhoGAP_pG1_pG2 X X +PTK6 Brk Q13882 human Brk 5753 Q13882 PTK6 human Y447 450276 RLSSFtsyENPT___ X +PTK6 Brk Q13882 human KHDRBS1 20218 Q60749 Khdrbs1 mouse Y435 456717 ARPVkGAyREHPyGR X +PTK6 Brk Q13882 human Brk 5753 Q13882 PTK6 human Y342 450274 RLIKEDVyLsHDHNI PK_Tyr_Ser-Thr X +PTK6 Brk Q13882 human P130Cas 9564 P56945 BCAR1 human Y664 448399 EGGWMEDyDyVHLQG CAS_C X X +PTK6 Brk Q13882 human CTNNB1 1499 P35222 CTNNB1 human Y333 471406 NIMRTytyEkLLWTT X +PTK6 Brk Q13882 human KHDRBS1 20218 Q60749 Khdrbs1 mouse Y440 456716 GAyREHPyGRy____ X +PTK6 Brk Q13882 human Akt1 207 P31749 AKT1 human Y326 447858 EVLEDNDyGRAVDWW Pkinase X X +PTK6 Brk Q13882 human Akt1 207 P31749 AKT1 human Y315 448519 tFCGtPEyLAPEVLE Pkinase X X +PTK6 Brk Q13882 human STAT5B 6777 P51692 STAT5B human Y699 448198 tAkAVDGyVkPQIkQ X X 9365; 9356; 9359; 9351; 4322; 9314; 3939; 40284; 5387; 14603; 66740; 51879; 72712 +PTK6 Brk Q13882 human KHDRBS1 20218 Q60749 Khdrbs1 mouse Y443 456715 REHPyGRy_______ X +Mapk13 P38D Q9Z1B7 mouse DLG1 25252 Q62696 Dlg1 rat S122 3195032 VLPSERIsPQVPNEV MAGUK_N_PEST X +Mapk13 P38D Q9Z1B7 mouse DLG1 1739 Q12959 DLG1 human S122 3195032 tPPQEHIsPQItNEV MAGUK_N_PEST X +Mapk13 P38D Q9Z1B7 mouse DLG1 1739 Q12959 DLG1 human T209 35547401 VNTDSLEtPTYVNGT MAGUK_N_PEST X +Mapk13 P38D Q9Z1B7 mouse GYS1 2997 P13807 GYS1 human T84 1875332200 VELLEAPtPALkRTL Glycogen_syn X +Mapk13 P38D Q9Z1B7 mouse DLG1 25252 Q62696 Dlg1 rat T209 35547401 VNTDSLEtPTYVNGT MAGUK_N_PEST X +Mapk13 P38D Q9Z1B7 mouse GYS1 2997 P13807 GYS1 human S723 4787599 sssLStPsEPLsPts X +Mapk13 P38D Q9Z1B7 mouse DLG1 1739 Q12959 DLG1 human S158 2024309 FVsHsHIsPIKPTEA MAGUK_N_PEST X +Mapk13 P38D Q9Z1B7 mouse DLG1 25252 Q62696 Dlg1 rat S442 5931300 YLGQTPAsPARYsPI PDZ_assoc X +Mapk13 P38D Q9Z1B7 mouse DLG1 25252 Q62696 Dlg1 rat S447 15176604 PAsPARYsPISKAVL PDZ_assoc X +Mapk13 P38D Q9Z1B7 mouse DLG1 25252 Q62696 Dlg1 rat S158 2024309 FVSHSHIsPIKPTEA MAGUK_N_PEST X +Mapk13 P38D Q9Z1B7 mouse GYS1 2997 P13807 GYS1 human S727 457615 StPsEPLsPtssLGE X +Mapk13 P38D Q9Z1B7 mouse DLG1 25252 Q62696 Dlg1 rat S431 4749386 QSVDNHVsPSSYLGQ PDZ_assoc X +Mapk13 P38D Q9Z1B7 mouse GYS1 2997 P13807 GYS1 human T721 457616 AtsssLStPsEPLsP X +Mapk13 P38D Q9Z1B7 mouse GYS1 2997 P13807 GYS1 human T278 1875332700 kRkPDIVtPNGLNVk Glycogen_syn X +Chek1 Chk1 O35280 mouse H3 360198 P68433 H3c1 mouse T11 455680 kQTARkstGGkAPrk Histone X 9767; 9764 +ULK1 ULK1 O75385 human CDC37 11140 Q16543 CDC37 human S339 62877802 HMQRCIDsGLWVPNs CDC37_C X X +ULK1 ULK1 O75385 human ATG9A 79065 Q7Z3C6 ATG9A human S761 4722321 QsIPRsAsYPCAAPR X X +ULK1 ULK1 O75385 human AMPKA1 65248 P54645 Prkaa1 rat T368 25778000 FLDDHHLtRPHPERV X +ULK1 ULK1 O75385 human ULK1 22241 O70405 Ulk1 mouse S1047 10428800 RRLsALLsGVYA___ DUF3543 X X +ULK1 ULK1 O75385 human FBPase 2203 P09467 FBP1 human S88 55578725 LVMNMLKsSFATCVL FBPase X +ULK1 ULK1 O75385 human RIPK1 8737 Q13546 RIPK1 human T337 1868502604 ssRsNsAtEQPGSLH X +ULK1 ULK1 O75385 human MCR 4306 P08235 NR3C2 human S843 29669801 NEEKMHQsAMYELCQ Hormone_recep X X +ULK1 ULK1 O75385 human STX17 55014 P56962 STX17 human S289 4774791 MMEKLtSsCPDLPSQ X X +ULK1 ULK1 O75385 human AMPKB2 64562 Q9QZH4 Prkab2 rat T39 4739308 HKIMVGstDDPSVFS X +ULK1 ULK1 O75385 human RIPK1 8737 Q13546 RIPK1 human S296 56657827 YLsQLEEsVEEDVks X +ULK1 ULK1 O75385 human SMCR8 140775 Q8TEV9 SMCR8 human S400 31880997 PSQDRPPsSsLEECP X +ULK1 ULK1 O75385 human STING 340061 Q86WV6 STING1 human S366 31064700 QEPELLIsGMEkPLP X X 30495; 39887; 85735; 50907; 19781; 41622; 43499; 40818; 99309; 72650 +ULK1 ULK1 O75385 human BNIP3L 665 O60238 BNIP3L human S35 65958201 PPAGLNssWVELPMN BNIP3 X +ULK1 ULK1 O75385 human ATG13 9776 O75143 ATG13 human S355 21127300 DTETVSNssEGRAsP X X 26839; 46329 +ULK1 ULK1 O75385 human AMPKG1 25520 P80385 Prkag1 rat T262 25778003 NNLDVsVtKALQHRs X +ULK1 ULK1 O75385 human AMPKB2 64562 Q9QZH4 Prkab2 rat S38 3175295 EHKIMVGstDDPSVF X 82791 +ULK1 ULK1 O75385 human YAP1 10413 P46937 YAP1 human S227 1874514400 VQQNMMNsASGPLPD X X +ULK1 ULK1 O75385 human AMPKA1 65248 P54645 Prkaa1 rat S397 7445993 DELNPQKsKHQGVRK X +ULK1 ULK1 O75385 human ATG16L1 55054 Q676U5 ATG16L1 human S278 15425208 PAGGLLDsITNIFGR X X 45511; 84300 +ULK1 ULK1 O75385 human AMPKA1 65248 P54645 Prkaa1 rat S486 3195155 DEITEAKsGtAtPQR AdenylateSensor X +ULK1 ULK1 O75385 human SQSTM1 8878 Q13501 SQSTM1 human S349 14580829 sskEVDPstGELQsL X X 95697; 16177; 12074 +ULK1 ULK1 O75385 human ATG9A 79065 Q7Z3C6 ATG9A human S14 3203970 EyQRLEAsysDsPPG X X +ULK1 ULK1 O75385 human beclin 1 56208 O88597 Becn1 mouse S14 25268704 SSSTMQVsFVCQRCS X X 84966 +ULK1 ULK1 O75385 human RIPK1 8737 Q13546 RIPK1 human S335 209632700 VPssRsNsAtEQPGS X +ULK1 ULK1 O75385 human PFKM 5213 P08237 PFKM human S762 55569802 yEIDLDTsDHAHLEH X X +ULK1 ULK1 O75385 human beclin 1 8678 Q14457 BECN1 human S30 7446159 QPLkLDTsFkILDRV X X 54101; 35955 +ULK1 ULK1 O75385 human Raptor 57521 Q8N122 RPTOR human S792 2314600 DKMRRAssYSsLNSL X X 2083; 89146 +ULK1 ULK1 O75385 human Raptor 57521 Q8N122 RPTOR human S877 3205938 HIHQAGGsPPAssts X +ULK1 ULK1 O75385 human LDH-A 16828 P06151 Ldha mouse S196 1881982200 VLGEHGDsSVPVWSG X X +ULK1 ULK1 O75385 human AMPKB2 64562 Q9QZH4 Prkab2 rat S173 25778001 KLDSMESsETSCRDL X +ULK1 ULK1 O75385 human beclin 1 8678 Q14457 BECN1 human S337 41389909 LVPyGNHsYLESLTD APG6 X +ULK1 ULK1 O75385 human ENO1 2023 P06733 ENO1 human S282 22777189 QLADLyksFIkDyPV Enolase_C X X +ULK1 ULK1 O75385 human beclin 1 8678 Q14457 BECN1 human S96 472002 MstEsANsFTLIGEA X +ULK1 ULK1 O75385 human RB1CC1 9821 Q8TDY2 RB1CC1 human S986 31088112 ELQsLEQsHLkELED X +ULK1 ULK1 O75385 human RB1CC1 9821 Q8TDY2 RB1CC1 human S943 41389910 EMENIMHsQNCEIKE X +ULK1 ULK1 O75385 human SMCR8 140775 Q8TEV9 SMCR8 human S562 55469602 IRFQASIsPPELGET X +ULK1 ULK1 O75385 human PIKFYVE 18711 Q9Z1T6 Pikfyve mouse S327 4920349 MVPSYETsVsPQANR X +ULK1 ULK1 O75385 human syntenin 6386 O00560 SDCBP human S60 23150265 LsQyMGLsLNEEEIR Peptidase_M50 X +ULK1 ULK1 O75385 human ATG4B 23192 Q9Y4P1 ATG4B human S316 2527072 SIAELDPsIAVGFFC Peptidase_C54 X X +ULK1 ULK1 O75385 human SESN2 83667 P58004 SESN2 human S254 1869992400 NNsGGFEsARDVEAL PA26 X +ULK1 ULK1 O75385 human RAB9A 56382 Q9R0M6 Rab9a mouse S179 3191548 ILAtEDRsEHLIQTD X +ULK1 ULK1 O75385 human AMPKG1 25520 P80385 Prkag1 rat S269 25778004 tKALQHRsHYFEGVL CBS X +ULK1 ULK1 O75385 human ULK1 8408 O75385 ULK1 human S317 35495300 SHLASPPsLGEMQQL X 12753; 37762 +ULK1 ULK1 O75385 human RIPK1 8737 Q13546 RIPK1 human S291 1868502608 kFRPFYLsQLEEsVE X +ULK1 ULK1 O75385 human PIKFYVE 18711 Q9Z1T6 Pikfyve mouse S1548 4272931 DtsPRNIsPGLHNGE X +ULK1 ULK1 O75385 human syntenin 6386 O00560 SDCBP human S6 4148819 __MsLyPsLEDLkVD X +ULK1 ULK1 O75385 human HK1 3098 P19367 HK1 human S124 55569800 NIVHGSGsQLFDHVA Hexokinase_1 X X +ULK1 ULK1 O75385 human RIPK1 8737 Q13546 RIPK1 human S345 1868502606 EQPGSLHssQGLGMG X +ULK1 ULK1 O75385 human BNIP3 664 Q12983 BNIP3 human S17 27421704 QEESLQGsWVELHFs BNIP3 X +ULK1 ULK1 O75385 human SESN2 83667 P58004 SESN2 human S73 1869992401 GLEALMSsGRVDNLA PA26 X +ULK1 ULK1 O75385 human AMBRA1 55626 Q9C0C7 AMBRA1 human S635 30963588 ssSRLELsSSAsPQE X +ULK1 ULK1 O75385 human SMCR8 140775 Q8TEV9 SMCR8 human S492 484907 SKsDsQAsLtVPLsP X +ULK1 ULK1 O75385 human DENND3 22898 A2RUS2 DENND3 human S490 23050193 ELAPRNSsLRLtDTA X X +ULK1 ULK1 O75385 human AMPKA1 65248 P54645 Prkaa1 rat S360 7320945 LATSPPDsFLDDHHL X +ULK1 ULK1 O75385 human FLCN 201163 Q8NFG4 FLCN human S406 35542208 CVRIIPYsSQYEEAY Folliculin_C X X +ULK1 ULK1 O75385 human AMBRA1 55626 Q9C0C7 AMBRA1 human S465 5735057 SQASVYTsATEGRGF X +ULK1 ULK1 O75385 human Raptor 57521 Q8N122 RPTOR human S855 3205935 QRVLDtssLtQsAPA X X +ULK1 ULK1 O75385 human Raptor 57521 Q8N122 RPTOR human S859 2024885 DtssLtQsAPAsPtN X X +ULK1 ULK1 O75385 human SQSTM1 8878 Q13501 SQSTM1 human S403 22264800 ESLSQMLsMGFsDEG UBA_5 X 39786 +ULK1 ULK1 O75385 human ATG13 51897 Q91YI1 Atg13 mouse S354 21127300 DTETVSNsSEGRAsP X X 26839; 46329 +ULK1 ULK1 O75385 human SEC23A 10484 Q15436 SEC23A human S207 89117912 LQEMLGLskVPLTQA Sec23_trunk X X +ULK1 ULK1 O75385 human ATG13 9776 O75143 ATG13 human S389 41389905 INQVTLTsLDIPFAM X +ULK1 ULK1 O75385 human FBPase 2203 P09467 FBP1 human S63 55578726 HLyGIAGsTNVTGDQ FBPase X X +ULK1 ULK1 O75385 human AMPKB2 64562 Q9QZH4 Prkab2 rat S68 25778002 WQQDLDDsVKPTQQA X +ULK1 ULK1 O75385 human SQSTM1 18412 Q64337 Sqstm1 mouse S351 14580829 SsKEVDPsTGELQsL X X 95697; 16177; 12074 +ULK1 ULK1 O75385 human SMCR8 140775 Q8TEV9 SMCR8 human T666 55469603 ASRDISktsLDNYSD X +ULK1 ULK1 O75385 human PFKM 5213 P08237 PFKM human S74 55569803 EATWESVsMMLQLGG PFK X +ULK1 ULK1 O75385 human RIPK1 8737 Q13546 RIPK1 human S357 1868502603 GMGPVEEsWFAPSLE X X +ULK1 ULK1 O75385 human PARK2 5071 O60260 PRKN human S108 17550101 sLTRVDLsssVLPGD X X 36728 +ULK1 ULK1 O75385 human SQSTM1 18412 Q64337 Sqstm1 mouse S405 22264800 ESLSQMLsMGFsDEG UBA_5 X 39786 +ULK1 ULK1 O75385 human ATG101 60673 Q9BSB4 ATG101 human S203 41389907 ITDALGTsVTTTMRR X +ULK1 ULK1 O75385 human RIPK1 8737 Q13546 RIPK1 human S389 451866 ANyHLyGsRMDRQTK X +ULK1 ULK1 O75385 human SEC23B 10483 Q15437 SEC23B human S186 1394461700 SCEGISksYVFRGTk Sec23_trunk X X +ULK1 ULK1 O75385 human ENO1 2023 P06733 ENO1 human S115 55578724 ANAILGVsLAVCkAG Enolase_N X +ULK1 ULK1 O75385 human Raptor 57521 Q8N122 RPTOR human S863 453732 LtQsAPAsPtNkGVH X +ULK1 ULK1 O75385 human SQSTM1 18412 Q64337 Sqstm1 mouse S409 40253303 QMLsMGFsDEGGWLT UBA_5 X X +ULK1 ULK1 O75385 human PIKFYVE 18711 Q9Z1T6 Pikfyve mouse S710 1873645602 KILLLKCsIEYLYRE Cpn60_TCP1 X +ULK1 ULK1 O75385 human FLCN 201163 Q8NFG4 FLCN human S537 23107124 EDTQkLLsILGAsEE Folliculin_C X X +ULK1 ULK1 O75385 human FUNDC1 139341 Q8IVP5 FUNDC1 human S17 2025377 DyEsDDDsyEVLDLT X X +ULK1 ULK1 O75385 human FLCN 201163 Q8NFG4 FLCN human S542 23107127 LLsILGAsEEDNVKL Folliculin_C X X +ULK1 ULK1 O75385 human HK1 3098 P19367 HK1 human S364 55569801 TRLGVEPsDDDCVSV Hexokinase_2 X +ULK1 ULK1 O75385 human RIPK1 8737 Q13546 RIPK1 human S320 468644 AVVkRMQsLQLdCVA X 58274; 39341 +ULK1 ULK1 O75385 human RB1CC1 9821 Q8TDY2 RB1CC1 human S1323 41389911 EMQNVRTsLIAEQQT X +ULK1 ULK1 O75385 human RIPK1 8737 Q13546 RIPK1 human S333 4728178 VAVPssRsNsAtEQP X +ULK1 ULK1 O75385 human AMPKG1 25520 P80385 Prkag1 rat S260 15175992 TYNNLDVsVtKALQH X +ULK1 ULK1 O75385 human RIPK1 8737 Q13546 RIPK1 human S346 1868502607 QPGSLHssQGLGMGP X +ULK1 ULK1 O75385 human MAD1L1 8379 Q9Y6D9 MAD1L1 human S546 1868914507 RTKVLHMsLNPTsVA MAD X X +ULK1 ULK1 O75385 human beclin 1 8678 Q14457 BECN1 human S15 25268704 NNSTMQVsFVCQRCS X 84966 +ULK1 ULK1 O75385 human SEC16A 9919 O15027 SEC16A human S846 55578720 LAQPINFsVSLSNSH X +ULK1 ULK1 O75385 human ATG14 22863 Q6ZNE5 ATG14 human S29 4758494 LARDLVDsVDDAEGL X 13155; 92340 +ULK1 ULK1 O75385 human SEC23A 10484 Q15436 SEC23A human T405 18913536 FKMGFGGtLEIKTSR Sec23_BS X X +ULK1 ULK1 O75385 human ATG101 60673 Q9BSB4 ATG101 human S11 41389906 RSEVLEVsVEGRQVE ATG101 X 75959 +ULK1 ULK1 O75385 human AMPKA1 65248 P54645 Prkaa1 rat T488 3195167 ITEAKsGtAtPQRSG AdenylateSensor X +ULK1 ULK1 O75385 human PIKFYVE 18711 Q9Z1T6 Pikfyve mouse T309 5208531 RNRsAsItNLsLDRS X +ULK1 ULK1 O75385 human ULK1 22241 O70405 Ulk1 mouse T180 21041603 QSNMMAAtLCGSPMY Pkinase X X 50936; 88311 +ULK1 ULK1 O75385 human PIK3C3 5289 Q8NEB9 PIK3C3 human S249 35483209 ESsPILTsFELVKVP X X 13857 +ULK1 ULK1 O75385 human DENND3 22898 A2RUS2 DENND3 human S472 7997148 THRRMVVsMPNLQDI X X +ULK1 ULK1 O75385 human RIPK1 8737 Q13546 RIPK1 human S262 1868502605 YCPREIIsLMKLCWE PK_Tyr_Ser-Thr X +ULK1 ULK1 O75385 human beclin 1 8678 Q14457 BECN1 human S279 41389908 ATFHIWHsGQFGTIN APG6 X +ULK1 ULK1 O75385 human FLI 2314 Q13045 FLII human S64 1163832400 KLEHLSVsHNNLTTL LRR_8 X +BCKDK BCKDK O14874 human BCKDH E1-alpha 25244 P11960 Bckdha rat S333 449636 TYRIGHHstsDDSSA E1_dh X 40368 +BCKDK BCKDK O14874 human BCKDH E1-alpha 25244 P11960 Bckdha rat S343 451657 DDSSAyRsVDEVNYW E1_dh X +Srpk2 SRPK2 NP_001100045 rat RIMS1 84556 Q9JIR4 Rims1 rat S1078 4725320 RPDTSLHsPERERHS X +Srpk2 SRPK2 NP_001100045 rat RIMS1 84556 Q9JIR4 Rims1 rat S287 455664 KQASRSRsEPPRERK X +Srpk2 SRPK2 NP_001100045 rat RIMS1 84556 Q9JIR4 Rims1 rat S447 2761601 ARVsPPEsPRARAAA X +Srpk2 SRPK2 NP_001100045 rat RIMS1 84556 Q9JIR4 Rims1 rat S1045 4725312 PRAKRGRsAESLHMT X +Srpk2 SRPK2 NP_001100045 rat RIMS1 84556 Q9JIR4 Rims1 rat S1066 3926128 LDRARSAsTNCLRPD X +MAPK9 JNK2 iso2 P45984-2 human MFN2 9927 O95140 MFN2 human S27 25594503 HMAEVNAsPLkHFVT X X +MAPK9 JNK2 iso2 P45984-2 human STAT3 6774 P40763 STAT3 human S727 448191 NtIDLPMsPrTLDSL X X 9134; 9136; 34911; 94994; 49081; 58978; 87544; 71958; 50804 +TEC TEC P42680 human FGF2 14173 P15655 Fgf2 mouse Y81 13823202 KGVCANRyLAMKEDG FGF X X +TEC TEC P42680 human BDP1 26469 Q99952 PTPN18 human Y389 449000 sAEEAPLysKVtPRA X +TEC TEC P42680 human Etk 660 P51813 BMX human Y216 449835 SSTSLAQyDSNSKKI X +TEC TEC P42680 human FGF2 14173 P15655 Fgf2 mouse Y111 4942757 ERLESNNyNTYRSRK FGF X +TEC TEC P42680 human TEC 7006 P42680 TEC human Y206 449836 RLERGQEyLILEKND SH3_1 X +TEC TEC P42680 human FGF2 14173 P15655 Fgf2 mouse Y123 13823201 SRKYSSWyVALKRTG FGF X +TEC TEC P42680 human BDP1 26469 Q99952 PTPN18 human Y303 450260 LQNASPHyQNIKENC X +TEC TEC P42680 human Btk 695 Q06187 BTK human Y223 447485 LKKVVALyDyMPMNA SH3_1 X 5082; 87141; 87457 +TEC TEC P42680 human ITK 3702 Q08881 ITK human Y180 449834 ETVVIALyDyQtNDP SH3_1 X +TEC TEC P42680 human BDP1 26469 Q99952 PTPN18 human Y281 450259 AVQTEEQyRFLYHTV Y_phosphatase X +TEC TEC P42680 human FGF2 iso3 2247 P09038-2 FGF2 human Y82 13823202 KGVCANRyLAMKEDG FGF X +TEC TEC P42680 human BDP1 26469 Q99952 PTPN18 human Y354 450261 GHAMADTyAVVQKRG X +ALDOA ALDOA P00883 rabbit ALDOA 100009055 P00883 ALDOA rabbit H362 451798 ESLFISNhAY_____ Glycolytic X +STK19 G11 iso1 P49842-1 human NRas 4893 P01111 NRAS human S89 1867735502 FAINNSksFADINLY Ras X X +Mark1 MARK1 Q8VHJ5 mouse KIFAP3 16579 P70188 Kifap3 mouse S60 4711034 QKIIRLKsLNANtDI KAP X +PIK3C2A PIK3C2A O00443 human PKCI 5584 P41743 PRKCI human T564 2839109 tNEPVQLtPDDDDIV Pkinase_C X +PIK3C2A PIK3C2A O00443 human p70S6K 72508 Q8BSK8 Rps6kb1 mouse T412 448607 NQVFLGFtYVAPSVL Pkinase_C X 9206; 9234; 9205; 97596 +PIK3C2A PIK3C2A O00443 human SGK1 6446 O00141 SGK1 human T256 448431 EHNSTTStFCGTPEY Pkinase X +PIK3C2A PIK3C2A O00443 human Akt1 11651 P31750 Akt1 mouse S473 447855 RPHFPQFsysAsGtA Pkinase_C X 9271; 3787; 4060; 4051; 5102; 4058; 2336; 2337; 4075; 4070; 5012; 4071; 92982; 5315; 9563; 9018; 12694; 52240; 11962; 15116; 88106; 26580; 68035; 31957; 23430; 20235 +DDR1 DDR1 Q08345 human DDR1 780 Q08345 DDR1 human Y569 1869973810 PQNSVPHyAEADIVT X +DDR1 DDR1 Q08345 human DDR1 780 Q08345 DDR1 human Y586 1869973809 GVTGGNTyAVPALPP X +Mast4 MAST4 Q811L6 mouse ERM 104156 Q9CXC9 Etv5 mouse S367 451201 PPYQRRGsLQLWQFL X +EPHB6 EphB6 Q07497 chicken EphB6 418308 Q07497 EPHB6 chicken Y618 451264 yyIDPSTyEDPNEAI EphA2_TM X +EPHB6 EphB6 Q07497 chicken EphB6 418308 Q07497 EPHB6 chicken Y612 451263 RGLGVKyyIDPSTyE EphA2_TM X +EPHB6 EphB6 Q07497 chicken EphB6 418308 Q07497 EPHB6 chicken Y594 449769 SKRRETPyTDRLQQy EphA2_TM X +EPHB6 EphB6 Q07497 chicken EphB6 418308 Q07497 EPHB6 chicken Y611 461925 TRGLGVKyyIDPSTy EphA2_TM X +EPHB6 EphB6 Q07497 chicken EphB6 418308 Q07497 EPHB6 chicken Y796 449778 DDASNPTyTGALGCK PK_Tyr_Ser-Thr X +EPHB6 EphB6 Q07497 chicken EphB6 418308 Q07497 EPHB6 chicken Y601 461924 yTDRLQQyISTRGLG EphA2_TM X +Yes1 Yes Q04736 mouse Cortactin 13043 Q60598 Cttn mouse Y421 447702 RPPssPIyEDAAPFK X 4569 +Yes1 Yes Q04736 mouse PKCD 18753 P28867 Prkcd mouse Y332 450077 ILDNNGTyGKIWEGS X +Yes1 Yes Q04736 mouse PKCD 18753 P28867 Prkcd mouse Y311 447573 TTEsVGIyQGFEKKP X 2055 +Yes1 Yes Q04736 mouse Cortactin 13043 Q60598 Cttn mouse Y466 447703 TyTSEPVyETTEAPG X +TLK1 TLK1 Q9UKI8 human NEK1 4750 Q96PY6 NEK1 human Y315 15412670 ITKPAAKyGIPLAyk X +TLK1 TLK1 Q9UKI8 human AKTIP 64400 Q9H8T0 AKTIP human S237 1876861202 IEDPYAIsFSPWNPS X X +TLK1 TLK1 Q9UKI8 human H3 8350 P68431 H3C1 human S10 455676 tkQtArkstGGkAPr Histone X X 9701; 9711; 9606; 3465; 3642; 3377; 3475; 3458; 5764; 47398; 8481; 8552; 53348; 29237; 66065; 43185; 64522; 52725 +TLK1 TLK1 Q9UKI8 human AKTIP 64400 Q9H8T0 AKTIP human T22 1876861200 RsEGEEKtLtGDVKt X X +TLK1 TLK1 Q9UKI8 human RAD9A 5883 Q99638 RAD9A human T355 449818 EPstVPGtPPPKKFR X X +TLK1 TLK1 Q9UKI8 human RAD9A 5883 Q99638 RAD9A human S328 449812 VLPsIsLsPGPQPPK X X +TLK1 TLK1 Q9UKI8 human MAPKAPK5 8550 Q8IW41 MAPKAPK5 human S160 1876193500 NLLFKDNsLDAPVkL Pkinase X +TLK1 TLK1 Q9UKI8 human NEK1 4750 Q96PY6 NEK1 human T141 65958203 IFLTkDGtVQLGDFG Pkinase X X +TLK1 TLK1 Q9UKI8 human MAPKAPK5 8550 Q8IW41 MAPKAPK5 human S354 27452609 VsLKPLHsVNNPILR X X +TLK1 TLK1 Q9UKI8 human MAPKAPK5 8550 Q8IW41 MAPKAPK5 human S386 1876193502 HENGAEDsNVALEKL X +TLK1 TLK1 Q9UKI8 human NEK1 4750 Q96PY6 NEK1 human S14 51636237 LQKIGEGsFGKAILV Pkinase X +CDK1 CDK1 P06493 human TRIM32 22954 Q13049 TRIM32 human S335 3195095 sPEEVVAsPRAsPAk X +CDK1 CDK1 P06493 human MDM4 4194 O15151 MDM4 human S96 455615 SFSVkDPsPLyDMLR X X +CDK1 CDK1 P06493 human KPNA2 3838 P52292 KPNA2 human S62 459854 sFPDDAtsPLQENRN IBB X X +CDK1 CDK1 P06493 human NuMA-1 4926 Q14980 NUMA1 human T2055 472502 MAFsILNtPkkLGNs X X 14951 +CDK1 CDK1 P06493 human Tau iso8 4137 P10636-8 MAPT human T231 449079 KKVAVVRtPPKsPss X 20473; 71429 +CDK1 CDK1 P06493 human NUDE1 iso1 54820 Q9NXR1-1 NDE1 human S282 469633 RNLVyDQsPNRtGGP NUDE_C X +CDK1 CDK1 P06493 human NCL 4691 P19338 NCL human T121 470366 PGkALVAtPGkkGAA X +CDK1 CDK1 P06493 human SAS6 163786 Q6UVJ0 SASS6 human T495 15414716 DVLGPSTtPPAHsSS X X +CDK1 CDK1 P06493 human STMN1 29332 P13668 Stmn1 rat S38 448556 SVPEFPLsPPKKkDL Stathmin X 3426; 4191 +CDK1 CDK1 P06493 human SIRT3 23410 Q9NTG7 SIRT3 human S159 41655506 SGIPDFRsPGSGLYS SIR2 X X +CDK1 CDK1 P06493 human NDUFB6 4712 O95139 NDUFB6 human S29 23253630 WLkDQELsPREPVLP NDUF_B6 X X +CDK1 CDK1 P06493 human STI1 20867 Q60864 Stip1 mouse T332 2907502 kSLAEHRtPDVLkKC X +CDK1 CDK1 P06493 human ARHGAP19 84986 Q14CB8 ARHGAP19 human T404 27443934 NkQSLTQtPGREPST X X +CDK1 CDK1 P06493 human Chk1 1111 O14757 CHEK1 human S286 465527 tsGGVsEsPsGFskH X +CDK1 CDK1 P06493 human CLASP2 23122 O75122 CLASP2 human S507 481392 QGCsREAsPsRLsVA X +CDK1 CDK1 P06493 human NOLC1 9221 Q14978 NOLC1 human T607 451911 AkKIkLQtPNtFPKR X +CDK1 CDK1 P06493 human NPM1 25498 P13084 Npm1 rat T235 449560 KQEKTPKtPkGPSsV X +CDK1 CDK1 P06493 human ATG13 9776 O75143 ATG13 human T342 1869357206 DRTHCAAtPSSSEDT X +CDK1 CDK1 P06493 human EPB41 iso2 2035 P11171-2 EPB41 human T60 467259 LKASNGDtPTHEDLT X +CDK1 CDK1 P06493 human IP3R1 3708 Q14643 ITPR1 human T800 450269 RDPQEQVtPVKYARL X +CDK1 CDK1 P06493 human ARHGEF2 9181 Q92974 ARHGEF2 human S960 467500 sRLsPPHsPRDFTRM X X +CDK1 CDK1 P06493 human RANGAP1 5905 P46060 RANGAP1 human T409 2906105 GQGEkSAtPSRkILD RanGAP1_C X +CDK1 CDK1 P06493 human VGLL4 iso4 9686 Q14135-4 VGLL4 human T159 3195944 AGLsPTLtPGERQQN VGLL4 X X +CDK1 CDK1 P06493 human SRm300 23524 Q9UQ35 SRRM2 human T1413 468856 VLDAVPRtPsRERss X +CDK1 CDK1 P06493 human CDC27 996 P30260 CDC27 human T209 455849 LtEtPQDtIELNRLN X +CDK1 CDK1 P06493 human NDUFB6 4712 O95139 NDUFB6 human T5 33402202 ___MtGYtPDEkLRL NDUF_B6 X X +CDK1 CDK1 P06493 human GJA1 2697 P17302 GJA1 human S255 448852 HAtsGALsPAkDCGs X +CDK1 CDK1 P06493 human CDC25C 398119 P30309 cdc25c-b frog T48 448419 FSPEQPLtPVTDLAV X +CDK1 CDK1 P06493 human YAP1 10413 P46937 YAP1 human S367 471290 GtQNPVssPGMsQEL X X +CDK1 CDK1 P06493 human MyoD 17927 P10085 Myod1 mouse S5 470072 ___MELLsPPLRDID X +CDK1 CDK1 P06493 human MyoD 17927 P10085 Myod1 mouse S200 40684505 SGDSDASsPRsNCSD Myf5 X +CDK1 CDK1 P06493 human amphiphysin 273 P49418 AMPH human S285 455793 NHTLAPAsPAPARPR X +CDK1 CDK1 P06493 human PAK1 18479 O88643 Pak1 mouse T212 448176 VIEPLPVtPtRDVAt X +CDK1 CDK1 P06493 human p70S6K 6198 P23443 RPS6KB1 human S447 448357 GsPRtPVsPVkFsPG X 9204 +CDK1 CDK1 P06493 human MLL5 55904 Q8IZD2 KMT2E human T912 14645300 PMDPSFAtPPRIKSD X +CDK1 CDK1 P06493 human RGPD4 285190 Q7Z3J3 RGPD4 human S1276 7321780 HAsPLAssPVRKNLF X +CDK1 CDK1 P06493 human HMGA1 3159 P17096 HMGA1 human T78 451516 ktrkttttPGrkPrG X +CDK1 CDK1 P06493 human ERK3 5597 Q16659 MAPK6 human S688 13830503 QFHsPVGsPLkSIQA X +CDK1 CDK1 P06493 human lamin A/C 16905 P48678 Lmna mouse S392 452606 ERLRLsPsPtsQRsR X +CDK1 CDK1 P06493 human treacle 6949 Q13428 TCOF1 human T983 469266 AQAQAAstPRKARAS X +CDK1 CDK1 P06493 human HMGCS1 3157 Q01581 HMGCS1 human S495 467990 IATEHIPsPAkkVPR X +CDK1 CDK1 P06493 human MASTL 84930 Q96GX5 MASTL human S875 3209091 tAQHLtVsGFsL___ X +CDK1 CDK1 P06493 human SLBP 7884 Q14493 SLBP human T62 466352 RRPEsFttPEGPkPR X +CDK1 CDK1 P06493 human DYN2 1785 P50570 DNM2 human S764 3191449 LQsAssHsPtPQRRP X +CDK1 CDK1 P06493 human MORC2 22880 Q9Y6X9 MORC2 human T717 3217917 PsPkVIKtPVVKKtE X +CDK1 CDK1 P06493 human p70S6K 83840 P67999 Rps6kb1 rat S447 448357 GsPRtPVsPVKFsPG X 9204 +CDK1 CDK1 P06493 human VGLL4 iso4 9686 Q14135-4 VGLL4 human S280 458220 SRRGQPAsPSAHMVS X X +CDK1 CDK1 P06493 human PPP1R13L 10848 Q8WUF5 PPP1R13L human S113 465657 LHPysPLsPKGrPss X +CDK1 CDK1 P06493 human EZH2 14056 Q61188 Ezh2 mouse T345 4957354 LtAERIKtPPKRPGG X 45153 +CDK1 CDK1 P06493 human YAP1 10413 P46937 YAP1 human S217 33668511 MNVTAPTsPPVQQNM X +CDK1 CDK1 P06493 human GRASP65 56082 O35254 Gorasp1 rat S376 467957 FEISFPDsPGSQAQV X +CDK1 CDK1 P06493 human FOXO1A 2308 Q12778 FOXO1 human S249 471071 EGGkSGksPrRrAAs X X +CDK1 CDK1 P06493 human SMAD2 Q1W668 SMAD2 cow S245 448794 NQSMDTGsPAELsPT X +CDK1 CDK1 P06493 human NIPA 51530 Q86WB0 ZC3HC1 human S395 478573 PGLEVPssPLRKAKR X +CDK1 CDK1 P06493 human SP1 6667 P08047 SP1 human T737 36897200 AGsEGSGtAtPSALI X X +CDK1 CDK1 P06493 human GRASP65 56082 O35254 Gorasp1 rat T220 4768150 PSAsSPGtPAKtPQP X +CDK1 CDK1 P06493 human PPP1CA 5499 P62136 PPP1CA human T320 448686 NPGGRPItPPRNsAK X 2581 +CDK1 CDK1 P06493 human MYPT1 116670 Q10728 Ppp1r12a rat S432 3545004 EEERKDEsPASWRLG X +CDK1 CDK1 P06493 human KIF20A 10112 O95235 KIF20A human S867 459835 CQsstDCsPyARILR X +CDK1 CDK1 P06493 human NuMA-1 4926 Q14980 NUMA1 human T2106 483675 tAAAIGAtPRAKGKA X +CDK1 CDK1 P06493 human CDC25A 993 P30304 CDC25A human S283 58934700 PErsQEEsPPGSTKr M-inducer_phosp X X +CDK1 CDK1 P06493 human ERK3 5597 Q16659 MAPK6 human S684 13830500 IGIPQFHsPVGsPLk X +CDK1 CDK1 P06493 human CENPA 1058 P49450 CENPA human S68 38520200 LIRKLPFsRLAREIC Histone X X +CDK1 CDK1 P06493 human DLG7 9787 Q15398 DLGAP5 human S839 456341 GGNLItFsPLQPGEF X +CDK1 CDK1 P06493 human MCM3 17215 P25206 Mcm3 mouse T719 449197 tQMPQVHtPKtDDsQ X +CDK1 CDK1 P06493 human PHLPP 23239 O60346 PHLPP1 human S411 1871700802 LPLPQtAssPQPQQK X X +CDK1 CDK1 P06493 human 53BP1 7158 Q12888 TP53BP1 human S1678 476255 ItsEEERsPAKRGRK X +CDK1 CDK1 P06493 human NIFK 84365 Q9BYG3 NIFK human T238 449333 QGPtPVCtPtFLERR hNIFK_binding X +CDK1 CDK1 P06493 human HMGA2 15364 P52927 Hmga2 mouse S59 11452900 PKGSKNKsPSKAAQK X +CDK1 CDK1 P06493 human p73 7161 O15350 TP73 human T86 449047 AASASPYtPEHAASV X X +CDK1 CDK1 P06493 human UBC9 7329 P63279 UBE2I human S71 3803343 FkDDYPssPPkCKFE UQ_con X X +CDK1 CDK1 P06493 human JUB 84962 Q96IF1 AJUBA human S175 17546438 GyDQRHGsPLPAGPC X +CDK1 CDK1 P06493 human CASP9 842 P55211 CASP9 human T125 449563 PEVLRPEtPRPVDIG X X +CDK1 CDK1 P06493 human CDCA5 113130 Q96FF9 CDCA5 human S126 20727702 NPEAEsssKEGELDA Sororin X X +CDK1 CDK1 P06493 human NCKAP5L 57701 Q9HCH0 NCKAP5L human S440 483853 KLQIGPPsPGEAQGP X +CDK1 CDK1 P06493 human CDC16 8881 Q13042 CDC16 human S112 455864 EkYLkDEsGFkDPSS X +CDK1 CDK1 P06493 human USP1 7398 O94782 USP1 human S313 3177796 AtsDtLEsPPKIIPK UCH X +CDK1 CDK1 P06493 human treacle 6949 Q13428 TCOF1 human S583 476272 LQAkPtssPAKGPPQ Treacle X +CDK1 CDK1 P06493 human TK 7083 P04183 TK1 human S13 448816 LPtVLPGsPskTRGQ X +CDK1 CDK1 P06493 human MARK2 2011 Q7KZI7 MARK2 human S569 2192738 PQRVPVAsPsAHNIs X +CDK1 CDK1 P06493 human TSC1 7248 Q92574 TSC1 human T1047 449364 SSSSELstPEKPPHQ X X +CDK1 CDK1 P06493 human CTDSPL2 51496 Q05D32 CTDSPL2 human T86 469354 DNNLITstPRAGEKP X X +CDK1 CDK1 P06493 human CDCA5 113130 Q96FF9 CDCA5 human T111 469415 ktHsVPAtPtStPVP Sororin X X +CDK1 CDK1 P06493 human RAP1GAP 5909 P47736 RAP1GAP human S484 3190705 SLIVPGKsPtRKKsG X +CDK1 CDK1 P06493 human KIF2C 11004 Q99661 KIF2C human T537 14157500 LGQNkAHtPFRESkL Kinesin X X +CDK1 CDK1 P06493 human CC2D1A 54862 Q6P1N0 CC2D1A human S208 483763 PAstPtysPAPtQPA X X +CDK1 CDK1 P06493 human Tip60 10524 Q92993 KAT5 human S86 448826 TKNGLPGsRPGsPER X X +CDK1 CDK1 P06493 human FOXK2 3607 Q01167 FOXK2 human S373 3193955 sSRsAPAsPNHAGVL X X +CDK1 CDK1 P06493 human GMPS 8833 P49915 GMPS human T318 3801478 PIsDEDRtPRKRISk NAD_synthase X +CDK1 CDK1 P06493 human dUTPase iso2 1854 P33316-2 DUT human S11 451166 sEEtPAIsPskRARP X +CDK1 CDK1 P06493 human DAB2IP iso2 153090 Q5VWQ8-2 DAB2IP human T546 3958578 GTNDLAStPGSGSSS DUF3498 X +CDK1 CDK1 P06493 human UGDH 7358 O60701 UGDH human T461 3963109 TIGFQIEtIGKKVSS X +CDK1 CDK1 P06493 human PKR 5610 P19525 EIF2AK2 human S83 3181640 NkEKkAVsPLLLttt X +CDK1 CDK1 P06493 human AML1 iso8 861 Q01196-8 RUNX1 human S276 454399 DTRQIQPsPPWSYDQ X +CDK1 CDK1 P06493 human eIF4G 1981 Q04637 EIF4G1 human S1231 449798 EAALPPVsPLkAALs X X +CDK1 CDK1 P06493 human IREB2 3658 P48200 IREB2 human S157 2850010 LQkAGkLsPLkVQPK X X +CDK1 CDK1 P06493 human TAZ 25937 Q9GZV5 WWTR1 human T285 41594200 AVNPPTMtPDMRsIT X +CDK1 CDK1 P06493 human RAP140 23272 Q9UK61 TASOR human T819 3952772 HEyELNStPDKKDyE X +CDK1 CDK1 P06493 human SRC-1 8648 Q15788 NCOA1 human T1426 18958502 KPTSGPQtPQAQQKS X +CDK1 CDK1 P06493 human AML1 iso8 861 Q01196-8 RUNX1 human S48 452744 TPPSTALsPGKMSEA X +CDK1 CDK1 P06493 human CHMP7 91782 Q8WUX9 CHMP7 human S441 4763991 GLVPSsKsPKRQLEP Snf7 X +CDK1 CDK1 P06493 human DENR 8562 O43583 DENR human S73 476007 AKLtVENsPKQEAGI X +CDK1 CDK1 P06493 human NDUFA12 55967 Q9UI09 NDUFA12 human T120 33402205 HKFNVTGtPEQYVPY NDUFA12 X X +CDK1 CDK1 P06493 human FOXM1 2305 Q08050 FOXM1 human T611 451437 ETLPISstPSkSVLP X +CDK1 CDK1 P06493 human Lamin B1 4001 P20700 LMNB1 human S393 454275 ErLkLsPsPssRVtV X +CDK1 CDK1 P06493 human RCC1 1104 P18754 RCC1 human T274 2850005 SNYHQLGtPGTESCF RCC1 X +CDK1 CDK1 P06493 human KIF22 3835 Q14807 KIF22 human S427 2999003 AsAsQkLsPLQkLSs X +CDK1 CDK1 P06493 human lamin A/C 4000 P02545 LMNA human T19 459855 sGAQAsstPLsPtRI X +CDK1 CDK1 P06493 human CDC14A 8556 Q9UNH5 CDC14A human S453 1216243801 KtSKMALsPSATAKR X X +CDK1 CDK1 P06493 human RFA2 6118 P15927 RPA2 human S29 448338 QsPGGFGsPAPsQAE X +CDK1 CDK1 P06493 human CDKN2D 1032 P55273 CDKN2D human S76 6046001 VQDTSGTsPVHDAAR Ank_2 X X +CDK1 CDK1 P06493 human FLNA 2316 P21333 FLNA human S1630 478650 GGDEIPFsPyRVRAV Filamin X +CDK1 CDK1 P06493 human TOP2A 7153 P11388 TOP2A human S1247 452238 kNENtEGsPQEDGVE X +CDK1 CDK1 P06493 human CDC14A 8556 Q9UNH5 CDC14A human S411 25733761 SQRQPRTsPSCAFRS X X +CDK1 CDK1 P06493 human APC1 64682 Q9H1A4 ANAPC1 human T537 455830 tPLDGVstPkPLsKL X +CDK1 CDK1 P06493 human BLM 641 P54132 BLM human S714 469110 PGVTVVIsPLRSLIV DEAD X +CDK1 CDK1 P06493 human TRF1 7013 P54274 TERF1 human T371 3727647 VSKsQPVtPEKHRAR X X +CDK1 CDK1 P06493 human CDC25B 994 P30305 CDC25B human S321 459625 KCQRLFRsPsMPCsV M-inducer_phosp X +CDK1 CDK1 P06493 human LIMD1 8994 Q9UGP4 LIMD1 human S277 451975 RVsPGLPsPNLENGA X +CDK1 CDK1 P06493 human NUP210 58958 P11654 Nup210 rat S1880 482838 SPPSGLWsPAYASH_ X +CDK1 CDK1 P06493 human AR 367 P10275 AR human S310 448413 TEDTAEysPFKGGYT Androgen_recep X X 61248 +CDK1 CDK1 P06493 human LIMD1 8994 Q9UGP4 LIMD1 human S272 451974 TASsQRVsPGLPsPN X +CDK1 CDK1 P06493 human TFCP2L1 81879 Q3UNW5 Tfcp2l1 mouse T177 38489957 HCISTEFtPRKHGGE CP2 X X +CDK1 CDK1 P06493 human CDC16 8881 Q13042 CDC16 human S560 455866 kTLkNIIsPPWDFRE X +CDK1 CDK1 P06493 human APC1 64682 Q9H1A4 ANAPC1 human S377 455827 NIssHNQsPkRHSIS X +CDK1 CDK1 P06493 human KIF20A 10112 O95235 KIF20A human S878 4712595 RILRsRRsPLLKsGP X +CDK1 CDK1 P06493 human CREM 1390 Q03060 CREM human S277 450066 AsPGsLHsPQQLAEE X X +CDK1 CDK1 P06493 human MAP4 4134 P27816 MAP4 human S696 449564 PNKELPPsPEKKTkP X X +CDK1 CDK1 P06493 human KIF20A 10112 O95235 KIF20A human S532 459833 KEHsLQVsPSLEkGA X +CDK1 CDK1 P06493 human SKA3 221150 Q8IX90 SKA3 human T358 459962 SYENLLRtPtPPEVT X X +CDK1 CDK1 P06493 human Diaphanous-1 1729 O60610 DIAPH1 human T768 3946102 PVLPFGLtPKkLykP X +CDK1 CDK1 P06493 human DLG1 1739 Q12959 DLG1 human S443 5931300 FLGQtPAsPARysPV PDZ_assoc X X +CDK1 CDK1 P06493 human ULK1 22241 O70405 Ulk1 mouse S638 2192504 DFPKtPssQNLLTLL X +CDK1 CDK1 P06493 human CENPC1 1060 Q03188 CENPC human T734 14571365 kLVLPsNtPNVRRTK X X +CDK1 CDK1 P06493 human ATG13 9776 O75143 ATG13 human S44 1869357207 ICTRSSSsPTGSDWF X +CDK1 CDK1 P06493 human CDC25C 995 P30307 CDC25C human S122 449910 DQHLMKCsPAQLLCS X +CDK1 CDK1 P06493 human CK2A1 1457 P68400 CSNK2A1 human T344 449984 SSMPGGStPVSSANM X +CDK1 CDK1 P06493 human MTHFR 4524 P42898 MTHFR human T34 456129 KDSSRCStPGLDPER X X +CDK1 CDK1 P06493 human MCL1 4170 Q07820 MCL1 human S64 479431 IGGSAGAsPPStLtP X 13297 +CDK1 CDK1 P06493 human ULK1 22241 O70405 Ulk1 mouse S622 2047929 PLPPILGsPtKAGPs X +CDK1 CDK1 P06493 human KIF22 3835 Q14807 KIF22 human T463 456110 QGAPLLstPkRERMV X +CDK1 CDK1 P06493 human CDC25C 995 P30307 CDC25C human S168 449022 SEMKyLGsPIttVPK X +CDK1 CDK1 P06493 human Caldesmon 373965 P12957 CALD1 chicken S717 448465 KtPEGNKsPAPKPSD Caldesmon X +CDK1 CDK1 P06493 human Akt1 207 P31749 AKT1 human S473 447855 RPHFPQFsysAsGtA Pkinase_C X 9271; 3787; 4060; 4051; 5102; 4058; 2336; 2337; 4075; 4070; 5012; 4071; 92982; 5315; 9563; 9018; 12694; 52240; 11962; 15116; 88106; 26580; 68035; 31957; 23430; 20235 +CDK1 CDK1 P06493 human USP24 23358 Q9UPU5 USP24 human S2604 3216276 HLQQGsEsPMMIGEL X +CDK1 CDK1 P06493 human AML1 iso8 861 Q01196-8 RUNX1 human T300 454403 sPSVHPAtPIsPGRA X +CDK1 CDK1 P06493 human Raptor 57521 Q8N122 RPTOR human S696 11315003 EKNyALPsPAttEGG X +CDK1 CDK1 P06493 human CDC27 996 P30260 CDC27 human T289 455852 FGILPLEtPsPGDGs X +CDK1 CDK1 P06493 human RAP80 51720 Q96RL1 UIMC1 human S677 453731 TRRDLNEsPVksFVS X X +CDK1 CDK1 P06493 human PHLPP 23239 O60346 PHLPP1 human S321 31863286 RRAsPAPsDssPGEP X X +CDK1 CDK1 P06493 human CDK7 1022 P50613 CDK7 human T170 448306 GsPNRAytHQVVtRW Pkinase X +CDK1 CDK1 P06493 human CDCA5 113130 Q96FF9 CDCA5 human S21 3208968 RsGPRAPsPtKPLRR X X +CDK1 CDK1 P06493 human Nlp 22981 Q9Y2I6 NINL human S589 17490600 NRHsPSWsPDGRRRQ X +CDK1 CDK1 P06493 human Tau iso8 4137 P10636-8 MAPT human S404 449082 PVVsGDtsPRHLsNV X 35834; 20194; 98523; 91600; 49562 +CDK1 CDK1 P06493 human TAZ 25937 Q9GZV5 WWTR1 human T346 41594202 TGENAGQtPMNINPQ X X +CDK1 CDK1 P06493 human DLG7 9787 Q15398 DLGAP5 human S618 456339 AGFFRVEsPVKLFsG X +CDK1 CDK1 P06493 human NFAT2 18018 O88942 Nfatc1 mouse S263 15412721 ARGsRPTsPCNKRKY X X +CDK1 CDK1 P06493 human RARA 19401 P11416 Rara mouse S77 455459 EIVPSPPsPPPLPRI X +CDK1 CDK1 P06493 human JUB 84962 Q96IF1 AJUBA human S119 483805 EPTAPALsPRSsFAs X X +CDK1 CDK1 P06493 human KI-67 4288 P46013 MKI67 human T761 3148266 GIAEMFktPVkEQPQ X +CDK1 CDK1 P06493 human ODF2 iso3 4957 Q5BJF6-3 ODF2 human S796 449230 YSTFLTSsPIRSRSP X +CDK1 CDK1 P06493 human IL16 3603 Q14005 IL16 human T757 11280303 TQGHPDGtPPKLDTA X +CDK1 CDK1 P06493 human SCML2 10389 Q9UQR0 SCML2 human T305 3216633 SssVkNItPRKKGPN RBR X X +CDK1 CDK1 P06493 human ULK1 22241 O70405 Ulk1 mouse T653 23070978 ARQGVVMtPPRNRtL X +CDK1 CDK1 P06493 human NEDD1 121441 Q8NHV4 NEDD1 human S411 3207015 ssLGDMFsPIRDDAV X +CDK1 CDK1 P06493 human USP9X 8239 Q93008 USP9X human S2547 483796 yEGsEEVsPPQtKDQ X X +CDK1 CDK1 P06493 human CDT1 81620 Q9H211 CDT1 human T402 20804634 PrPALPAtPPAtPPA X X +CDK1 CDK1 P06493 human PHLPP 23239 O60346 PHLPP1 human S335 15721886 PFVGGPVssPRAPRP X X +CDK1 CDK1 P06493 human TREX1 22040 Q91XB0 Trex1 mouse S78 2579811 IAPGKACsPGASEIT RNase_T X +CDK1 CDK1 P06493 human KIF20A 10112 O95235 KIF20A human S7 18011282 _MsQGILsPPAGLLs X +CDK1 CDK1 P06493 human CtIP 5932 Q99708 RBBP8 human S327 452473 ELPtRVssPVFGATS X +CDK1 CDK1 P06493 human PKN2 5586 Q16513 PKN2 human S535 3197384 VNHsGtFsPQAPVPT X +CDK1 CDK1 P06493 human CDC25A 993 P30304 CDC25A human S18 449976 RRLLFACsPPPASQP X +CDK1 CDK1 P06493 human CARHSP1 23589 Q9Y2V2 CARHSP1 human T23 3963128 AsVGLLDtPRsRERs X +CDK1 CDK1 P06493 human CDC25B iso2 994 P30305-2 CDC25B human S146 465509 PVRLLGHsPVLRNIT M-inducer_phosp X +CDK1 CDK1 P06493 human amphiphysin 273 P49418 AMPH human S272 455791 EEPsPLPsPTAsPNH X +CDK1 CDK1 P06493 human ATG13 9776 O75143 ATG13 human T332 27444371 QERLATCtPsDRTHC X +CDK1 CDK1 P06493 human Vimentin 7431 P08670 VIM human S55 476052 tsrsLyAssPGGVyA Filament_head X +CDK1 CDK1 P06493 human kindlin-1 55612 Q9BQL6 FERMT1 human S179 2508995 TAsGsSVsPGLYSKT X +CDK1 CDK1 P06493 human CCNB1 891 P14635 CCNB1 human S126 448814 PILVDTAsPsPMETs X X +CDK1 CDK1 P06493 human Bcl-9 607 O00512 BCL9 human T172 3150953 EPtPAQKtPAKVVYV X X +CDK1 CDK1 P06493 human NDEL1 81565 Q9GZM8 NDEL1 human S242 3685801 IPNGFGtsPLtPSAR NUDE_C X +CDK1 CDK1 P06493 human DSN1 79980 Q9H410 DSN1 human S331 10800768 SMQQLDPsPARKLLk MIS13 X +CDK1 CDK1 P06493 human EEF1D 1936 P29692 EEF1D human S133 455672 APQtQHVsPMRQVEP X +CDK1 CDK1 P06493 human CDC25C 995 P30307 CDC25C human T67 448420 LsILsGGtPkRCLDL X +CDK1 CDK1 P06493 human PHLPP 23239 O60346 PHLPP1 human S345 1871700801 RAPRPVVsDTESFSL X X +CDK1 CDK1 P06493 human BAD 572 Q92934 BAD human S91 447861 EGMGEEPsPFrGrsR Bcl-2_BAD X +CDK1 CDK1 P06493 human MEK1 5604 Q02750 MAP2K1 human T292 448287 EtPPRPRtPGRPLss Pkinase X X 26975 +CDK1 CDK1 P06493 human ARHGAP19 84986 Q14CB8 ARHGAP19 human T476 9831746 GsPAVtMtPtRLKWS X X +CDK1 CDK1 P06493 human CK2A1 1457 P68400 CSNK2A1 human S362 449986 ISSVPtPsPLGPLAG X +CDK1 CDK1 P06493 human HMGA1 117062 Q8K585 Hmga1 rat T53 451515 KEPSEVPtPKRPRGR X +CDK1 CDK1 P06493 human RRM2 6241 P31350 RRM2 human T33 3189775 sLVdkENtPPALsGt X 74736 +CDK1 CDK1 P06493 human STMN1 3925 P16949 STMN1 human S25 448555 QAFELILsPrskEsV Stathmin X X +CDK1 CDK1 P06493 human SP1 6667 P08047 SP1 human S720 36897202 GGPGVALsVGtLPLD X X +CDK1 CDK1 P06493 human NDUFS2 4720 O75306 NDUFS2 human S364 33402201 kVDDAKVsPPKRAEM Complex1_49kDa X X +CDK1 CDK1 P06493 human treacle 6949 Q13428 TCOF1 human S156 486513 ANLLsGksPRKsAEP X +CDK1 CDK1 P06493 human CDC25A 993 P30304 CDC25A human S116 449977 PQkLLGCsPALkRSH M-inducer_phosp X +CDK1 CDK1 P06493 human NDEL1 81565 Q9GZM8 NDEL1 human T219 468252 AsLsLPAtPVGKGTE NUDE_C X +CDK1 CDK1 P06493 human DDX3 1654 O00571 DDX3X human T323 457784 GCHLLVAtPGRLVDM DEAD X +CDK1 CDK1 P06493 human RAD9A 5883 Q99638 RAD9A human T355 449818 EPstVPGtPPPKKFR X X +CDK1 CDK1 P06493 human CTDSPL2 51496 Q05D32 CTDSPL2 human S134 4272262 EDNPsSGsPPRTTLL X X +CDK1 CDK1 P06493 human UGDH 83472 O70199 Ugdh rat T461 3963109 TIGFQIEtIGKKVSS X +CDK1 CDK1 P06493 human TSC1 7248 Q92574 TSC1 human S584 450280 ETsIFTPsPCKIPPP Hamartin X X +CDK1 CDK1 P06493 human ISL1 3670 P61371 ISL1 human S269 515814094 GTPMVAAsPERHDGG X +CDK1 CDK1 P06493 human AML1 iso8 861 Q01196-8 RUNX1 human S424 1308915 SMVGGERsPPRILPP RunxI X +CDK1 CDK1 P06493 human POLR2A 5430 P24928 POLR2A human S1920 452274 sPtysPtsPKysPts RNA_pol_Rpb1_R; RNA_pol_Rpb1_R X +CDK1 CDK1 P06493 human SCML2 10389 Q9UQR0 SCML2 human S511 449227 VPyVVPLsPKLPKTk X X +CDK1 CDK1 P06493 human CDCA2 157313 Q69YH5 CDCA2 human T412 3202359 DEsLPANtPLRKGGT PP1_bind X +CDK1 CDK1 P06493 human ORC6L 23594 Q9Y5N6 ORC6 human T195 470324 REPGDVAtPPRKRKk X +CDK1 CDK1 P06493 human kindlin-1 55612 Q9BQL6 FERMT1 human S176 31869918 ssPTAsGsSVsPGLY X +CDK1 CDK1 P06493 human CLASP2 23122 O75122 CLASP2 human S1012 14571702 LHSMPtHssPRsRDy X +CDK1 CDK1 P06493 human CTDSPL2 51496 Q05D32 CTDSPL2 human S104 3205830 ISRVRRKsQVNGEAG X X 5294 +CDK1 CDK1 P06493 human ULK1 22241 O70405 Ulk1 mouse S224 10428802 GKAPFQAsSPQDLRL Pkinase X +CDK1 CDK1 P06493 human Cortactin 2017 Q14247 CTTN human S405 447700 KtQtPPVsPAPQPtE X +CDK1 CDK1 P06493 human NR1D1 217166 Q3UV55 Nr1d1 mouse T275 55578702 SQFPQQLtPPRSPSP X X +CDK1 CDK1 P06493 human 53BP1 27223 P70399 Trp53bp1 mouse S382 452380 TPFIVPssPtEQGGR X +CDK1 CDK1 P06493 human DDHD1 80821 Q8NEL9 DDHD1 human S8 22351354 MNYPGrGsPRsPEHN X +CDK1 CDK1 P06493 human HJURP 55355 Q8NCD3 HJURP human S473 483759 MYRGGPAsPGGLQGL X +CDK1 CDK1 P06493 human NCAPD3 23310 P42695 NCAPD3 human T1415 10790749 VTkRAIstPEKsISD X X +CDK1 CDK1 P06493 human Caldesmon 373965 P12957 CALD1 chicken S597 3302700 KKPFKCFsPKGSsLK Caldesmon X +CDK1 CDK1 P06493 human DDX48 9775 P38919 EIF4A3 human T163 3190132 GQHVVAGtPGRVFDM DEAD X X +CDK1 CDK1 P06493 human GFAP 396562 F1RR02 GFAP pig S8 449618 MERRRVtsAARRsYV Filament_head X +CDK1 CDK1 P06493 human VCIP135 80124 Q96JH7 VCPIP1 human T761 472123 GPssAPAtPtkAPys X X +CDK1 CDK1 P06493 human RGPD5/6 84220 Q99666 RGPD6 human S1275 3963125 HAsPLAssPVRKNLF X +CDK1 CDK1 P06493 human MARK2 2011 Q7KZI7 MARK2 human S456 453135 sTAKVPAsPLPGLER X +CDK1 CDK1 P06493 human NPM1 4869 P06748 NPM1 human T234 449024 sFkkQEKtPKtPkGP X X +CDK1 CDK1 P06493 human NCKAP5L 57701 Q9HCH0 NCKAP5L human S477 3213123 sPGGPQLsPQLPRNS X +CDK1 CDK1 P06493 human CDCA5 113130 Q96FF9 CDCA5 human S181 20727382 AEDLsGVsPVVCsKL Sororin X X +CDK1 CDK1 P06493 human PHLPP 23239 O60346 PHLPP1 human T409 1871700800 QPLPLPQtAssPQPQ X X +CDK1 CDK1 P06493 human CLASP2 23122 O75122 CLASP2 human S1029 3175909 yNysDsIsPFNKsAL X +CDK1 CDK1 P06493 human PKN1 5585 Q16512 PKN1 human S537 483282 GTFsPGAsPGsEART X X +CDK1 CDK1 P06493 human CUEDC2 79004 Q9H467 CUEDC2 human S110 18008416 VQGQVPIsPEPLQRP X X +CDK1 CDK1 P06493 human NuMA-1 308870 F1LW91 Numa1 rat T2021 472502 MAFSILNtPKKLGNS X +CDK1 CDK1 P06493 human LIMD1 8994 Q9UGP4 LIMD1 human S421 3214989 LGSVLLDsPssPRVr X X +CDK1 CDK1 P06493 human desmin 13346 P31001 Des mouse S28 4705787 APGFsLGsPLssPVF Filament_head X +CDK1 CDK1 P06493 human KHDRBS1 10657 Q07666 KHDRBS1 human T317 18504947 rGALVrGtPVrGAIT X +CDK1 CDK1 P06493 human EEF2 1938 P13639 EEF2 human S595 27620701 NVLCLsksPNkHNRL X +CDK1 CDK1 P06493 human KHDRBS1 10657 Q07666 KHDRBS1 human T33 7990374 AHPsVRQtPsrQPPL X +CDK1 CDK1 P06493 human CDC25C 995 P30307 CDC25C human T130 449911 PAQLLCStPNGLDRG X +CDK1 CDK1 P06493 human CDC23 8697 Q9UJX2 CDC23 human T562 454344 QLRNQGEtPttEVPA X +CDK1 CDK1 P06493 human UBXN2B 137886 Q14CS0 UBXN2B human S56 3217941 PkATVFksPRtPPQR X +CDK1 CDK1 P06493 human LATS1 9113 O95835 LATS1 human T490 3146610 ATTVTAItPAPIQQP X +CDK1 CDK1 P06493 human HEC1 10403 O14777 NDC80 human T31 23112540 VNkQGLytPQTKEkP X X +CDK1 CDK1 P06493 human AAK1 22848 Q2M2I8 AAK1 human T389 483910 LPIQPALtPrKRATV X +CDK1 CDK1 P06493 human MCTS1 28985 Q9ULC4 MCTS1 human S118 26348500 IMCPGLTsPGAKLyP PUA X +CDK1 CDK1 P06493 human LIG3 3980 P49916 LIG3 human T191 2883701 LSSKAAGtPKKKAVV X +CDK1 CDK1 P06493 human CDK7 1022 P50613 CDK7 human S164 450041 GLAksFGsPNRAytH Pkinase X +CDK1 CDK1 P06493 human TUBB 22154 P99024 Tubb5 mouse S172 460692 NTFsVVPsPKVSDTV Tubulin X X +CDK1 CDK1 P06493 human RGPD8 727851 O14715 RGPD8 human S1275 7323381 HAsPLAssPVRKNLF X +CDK1 CDK1 P06493 human CREM 1390 Q03060 CREM human S271 450065 QGVVMAAsPGsLHsP X X +CDK1 CDK1 P06493 human MYPT1 116670 Q10728 Ppp1r12a rat S473 3174680 GVIRSASsPRLSSSL X +CDK1 CDK1 P06493 human SETD8 387893 Q9NQR1 KMT5A human S100 3213381 SKIySyMsPNKCSGM X X +CDK1 CDK1 P06493 human Tau iso8 4137 P10636-8 MAPT human T153 449076 DGKtKIAtPRGAAPP X +CDK1 CDK1 P06493 human RANBP2 5903 P49792 RANBP2 human S2280 452315 sALsPsKsPAkLNQs X +CDK1 CDK1 P06493 human POLH 80905 Q9JJN0 Polh mouse S668 4931282 QGKRNPKsPSASSSK X +CDK1 CDK1 P06493 human PHLPP 23239 O60346 PHLPP1 human S412 30988996 PLPQtAssPQPQQKA X X +CDK1 CDK1 P06493 human CDC27 996 P30260 CDC27 human T430 455860 INDsLEItkLDssII X +CDK1 CDK1 P06493 human SOX2 20674 P48432 Sox2 mouse S39 18913847 TGGNQkNsPDRVKRP X +CDK1 CDK1 P06493 human SREBP-1 6720 P36956 SREBF1 human S439 469115 AGsPFQSsPLSLGSR X X +CDK1 CDK1 P06493 human APP 351 P05067 APP human T743 448523 VEVDAAVtPEERHLS APP_amyloid X 3823; 6986 +CDK1 CDK1 P06493 human YAP1 10413 P46937 YAP1 human T119 4959542 AGtAGALtPQHVRAH X X +CDK1 CDK1 P06493 human PD-1 5133 Q15116 PDCD1 human S261 1881448300 PSGMGTSsPARRGSA X +CDK1 CDK1 P06493 human NUSAP1 51203 Q9BXS6 NUSAP1 human T338 3211263 GNsAAVItPFKLttE NUSAP X X +CDK1 CDK1 P06493 human SRm300 23524 Q9UQ35 SRRM2 human T866 453390 QANEQsVtPQRRsCF X +CDK1 CDK1 P06493 human Rb 5925 P06400 RB1 human T252 449821 PINGsPRtPRRGQNR X +CDK1 CDK1 P06493 human TEX14 56155 Q8IWB6 TEX14 human T727 25158903 SNLNNMSttEEYLIS X +CDK1 CDK1 P06493 human BUB1B 701 O60566 BUB1B human S670 3207630 TLsIkkLsPIIEDsR X +CDK1 CDK1 P06493 human STMN1 3925 P16949 STMN1 human S38 448556 sVPEFPLsPPkKkDL Stathmin X X 3426; 4191 +CDK1 CDK1 P06493 human CDC25C 398119 P30309 cdc25c-b frog S205 449022 CEMNILGsPISADPP M-inducer_phosp X +CDK1 CDK1 P06493 human NAGK 55577 Q9UJ70 NAGK human S76 3245045 RsLGLsLsGGDQEDA BcrAD_BadFG X +CDK1 CDK1 P06493 human NCAPG 64151 Q9BPX3 NCAPG human T308 5014903 LNALFSItPLSELVG X +CDK1 CDK1 P06493 human NUP50 10762 Q9UKX7 NUP50 human S221 476622 kVAAEtQsPsLFGst X X +CDK1 CDK1 P06493 human MAP4 4134 P27816 MAP4 human T917 2130501 SAkPssTtPRLSRLA X +CDK1 CDK1 P06493 human AKAP12 9590 Q02952 AKAP12 human T618 480420 AsFkkMVtPKKRVRR WSK X +CDK1 CDK1 P06493 human RANBP2 5903 P49792 RANBP2 human S2246 468567 ssssVHAsPLAssPV X +CDK1 CDK1 P06493 human NUDE1 iso1 54820 Q9NXR1-1 NDE1 human T215 469489 ATGsVPstPIAHRGP NUDE_C X +CDK1 CDK1 P06493 human CDC23 8697 Q9UJX2 CDC23 human T565 455847 NQGEtPttEVPAPFF X +CDK1 CDK1 P06493 human KIFC1 3833 Q9BW19 KIFC1 human S31 3211092 APsQLPLsGsRLKRR X +CDK1 CDK1 P06493 human PIP5K1C 23396 O60331 PIP5K1C human S650 457599 DERSWVysPLHYSAQ X +CDK1 CDK1 P06493 human EFHD2 79180 Q96C19 EFHD2 human S74 478224 QGIGEPQsPsRRVFN X +CDK1 CDK1 P06493 human NUP98 iso2 4928 P52948-2 NUP98 human S606 452729 RDSENLAsPSEYPEN X +CDK1 CDK1 P06493 human BORA 79866 Q6PGQ7 BORA human S252 7533203 SSGQFSSsPIQASAK X +CDK1 CDK1 P06493 human SKA3 221150 Q8IX90 SKA3 human S283 31863083 sDAEytNsPLVPTFC X +CDK1 CDK1 P06493 human CDT1 81620 Q9H211 CDT1 human S411 21440504 PAtPPAAsPsALkGV X X +CDK1 CDK1 P06493 human SQSTM1 8878 Q13501 SQSTM1 human T269 457004 GGkRsRLtPVsPEss X X 13121 +CDK1 CDK1 P06493 human NUP98 iso2 4928 P52948-2 NUP98 human T536 3801389 tPTHYKLtPRPATRV X +CDK1 CDK1 P06493 human NME2 83782 P19804 Nme2 rat T94 3182029 GRVMLGEtNPADskP NDK X +CDK1 CDK1 P06493 human SP1 6667 P08047 SP1 human T739 448227 sEGSGtAtPSALITT X X +CDK1 CDK1 P06493 human ING1 iso2 3621 Q9UK53-2 ING1 human S126 484008 LGDTAGNsGKAGADR X +CDK1 CDK1 P06493 human TTK 7272 P33981 TTK human S281 1737603 VPVNLLNsPDCDVkt X +CDK1 CDK1 P06493 human ADD1 118 P35611 ADD1 human S12 481591 SRAAVVtsPPPtTAP X 84214 +CDK1 CDK1 P06493 human TRIM32 22954 Q13049 TRIM32 human S328 2049721 TFREMDMsPEEVVAs X +CDK1 CDK1 P06493 human VCIP135 80124 Q96JH7 VCPIP1 human S768 3149749 tPtkAPysPttskEK X X +CDK1 CDK1 P06493 human PDK1 5170 O15530 PDPK1 human T354 25256100 WENLHQQtPPKLTAY X +CDK1 CDK1 P06493 human 4E-BP1 1978 Q13541 EIF4EBP1 human S83 447525 PtIPGVtsPssDEPP eIF_4EBP X X +CDK1 CDK1 P06493 human LIG3 3980 P49916 LIG3 human S913 2883700 EkLAtKssPVKVGEK X +CDK1 CDK1 P06493 human HBXAP 51773 Q96T23 RSF1 human S1375 3088513 LPstNGQsPGkAIEN X X +CDK1 CDK1 P06493 human BARD1 580 Q99728 BARD1 human S148 455770 NSIkMWFsPRSkKVR X +CDK1 CDK1 P06493 human BIM iso2 10018 O43521-2 BCL2L11 human S44 449602 QTEPQDRsPAPMSCD X +CDK1 CDK1 P06493 human lamin A/C 4000 P02545 LMNA human S390 452605 EEErLRLsPsPtsQR X +CDK1 CDK1 P06493 human ULK1 22241 O70405 Ulk1 mouse S991 1869357208 HAVQMVQsAALDEMF DUF3543 X +CDK1 CDK1 P06493 human amphiphysin 273 P49418 AMPH human S276 455792 PLPsPTAsPNHTLAP X +CDK1 CDK1 P06493 human PPP2CA 5515 P67775 PPP2CA human T304 450083 EPHVTRRtPDyFl__ X X +CDK1 CDK1 P06493 human NOLC1 64896 P41777 Nolc1 rat T612 451911 SKKVKLQtPNtFPKR X +CDK1 CDK1 P06493 human MORC2 22880 Q9Y6X9 MORC2 human T733 3217920 PIKLsPAtPsRKRsV X +CDK1 CDK1 P06493 human PYCR2 29920 Q96C36 PYCR2 human S304 483394 VSTLTPssPGkLLtR X +CDK1 CDK1 P06493 human CK2A1 1457 P68400 CSNK2A1 human T360 449985 SGISSVPtPsPLGPL X +CDK1 CDK1 P06493 human PRC1 9055 O43663 PRC1 human T481 483541 RrGLAPNtPGkARkL X X +CDK1 CDK1 P06493 human Bcl-xL 598 Q07817 BCL2L1 human S62 449099 PSWHLADsPAVNGAT X +CDK1 CDK1 P06493 human RANBP2 294429 NP_001178533 Ranbp2 rat S2126 468569 HAsPLAssPVRKNLF X +CDK1 CDK1 P06493 human NuMA-1 4926 Q14980 NUMA1 human S2087 28722901 tRSGtRRsPRIATTT X +CDK1 CDK1 P06493 human PAICS 10606 P22234 PAICS human S27 483584 EVyELLDsPGkVLLQ SAICAR_synt X +CDK1 CDK1 P06493 human NME1 191575 Q05982 Nme1 rat S120 450098 GRNIIHGsDSVEsAE NDK X +CDK1 CDK1 P06493 human NuMA-1 4926 Q14980 NUMA1 human T2015 472014 SCFPRPMtPRDRHEG X +CDK1 CDK1 P06493 human YAP1 10413 P46937 YAP1 human S128 485035 QHVRAHssPAsLQLG X X +CDK1 CDK1 P06493 human RANGAP1 19387 P46061 Rangap1 mouse T411 2906105 GSGEEPAtPSRKILD RanGAP1_C X +CDK1 CDK1 P06493 human RFC1 5981 P35251 RFC1 human T506 2915401 KESKLERtPQkNVQG X +CDK1 CDK1 P06493 human OSBP2 23762 Q969R2 OSBP2 human S762 11171320 ECSKVMHssPssPsS Oxysterol_BP X +CDK1 CDK1 P06493 human BAG3 9531 O95817 BAG3 human S284 469168 EGsPARsstPLHsPs X +CDK1 CDK1 P06493 human PICH 54821 Q2NKX8 ERCC6L human T1063 474544 VKQFDAstPkNDIsP X +CDK1 CDK1 P06493 human BRCA2 675 P51587 BRCA2 human S3291 455462 sPICTFVsPAAQKAF X +CDK1 CDK1 P06493 human NDUFV1 4723 P49821 NDUFV1 human T383 33402200 HESCGQCtPCREGVD NADH_4Fe-4S X X +CDK1 CDK1 P06493 human TTDN1 136647 Q8TAP9 MPLKIP human T120 478367 QGsPrTstPFGsGrV MPLKIP X +CDK1 CDK1 P06493 human NUDE1 iso1 54820 Q9NXR1-1 NDE1 human T228 449452 GPsssLNtPGsFRRG NUDE_C X +CDK1 CDK1 P06493 human TEX14 56155 Q8IWB6 TEX14 human T728 25158901 NLNNMSttEEYLISK X +CDK1 CDK1 P06493 human Survivin 332 O15392 BIRC5 human T34 447705 FLEGCACtPERMAEA BIR X X 8888 +CDK1 CDK1 P06493 human UNG 7374 P13051 UNG human S64 2018601 EPGtPPssPLsAEQL X +CDK1 CDK1 P06493 human SMAD2 Q1W668 SMAD2 cow T220 448793 QSNYIPEtPPPGYIS X +CDK1 CDK1 P06493 human SKA3 221150 Q8IX90 SKA3 human T291 459961 PLVPTFCtPGLkIPS X +CDK1 CDK1 P06493 human Vimentin 22352 P20152 Vim mouse S56 451514 sRsLysssPGGAyVt Filament_head X 3877; 7391 +CDK1 CDK1 P06493 human USP16 10600 Q9Y5T5 USP16 human S552 449274 DLEVLtssPtRNLNG UCH X X +CDK1 CDK1 P06493 human BUB1 699 O43683 BUB1 human S593 465612 CNktLAPsPksPGDF X +CDK1 CDK1 P06493 human LIG1 3978 P18858 LIG1 human S76 449246 EEEDEALsPAkGQKP X +CDK1 CDK1 P06493 human DNMT1 1786 P26358 DNMT1 human S154 476108 AkPEPsPsPRITRkS X +CDK1 CDK1 P06493 human MLK3 4296 Q16584 MAP3K11 human S548 4269787 GQAWGRQsPRRLEDs X X +CDK1 CDK1 P06493 human BRCA1 672 P38398 BRCA1 human S114 18007298 FAkKENNsPEHLkDE X +CDK1 CDK1 P06493 human dynactin 6 10671 O00399 DCTN6 human T186 27933603 KTMKGSStPVKN___ X +CDK1 CDK1 P06493 human Rb 5925 P06400 RB1 human S249 447975 AVIPINGsPRtPRRG X +CDK1 CDK1 P06493 human IRS2 8660 Q9Y4H2 IRS2 human S391 1984215 sVAGsPLsPGPVRAP X +CDK1 CDK1 P06493 human Haspin 83903 Q8TF76 HASPIN human T128 3952695 RPPQKCStPCGPLRL X +CDK1 CDK1 P06493 human FOXK2 3607 Q01167 FOXK2 human S428 3193961 FAQsAPGsPLssQPV X +CDK1 CDK1 P06493 human CDC27 996 P30260 CDC27 human T343 455858 sGNsREVtPILAQTQ X +CDK1 CDK1 P06493 human Chk1 1111 O14757 CHEK1 human S301 465528 IQsNLDFsPVNsAss X X +CDK1 CDK1 P06493 human palladin 23022 Q8WX93 PALLD human S766 3963122 SsLPsPMsPTPrQFG X +CDK1 CDK1 P06493 human CDC25B iso2 994 P30305-2 CDC25B human S307 459625 KCQRLFRsPsMPCSV M-inducer_phosp X +CDK1 CDK1 P06493 human NCKAP5L 57701 Q9HCH0 NCKAP5L human S571 3213138 RStFRGPsPEPPPsP X +CDK1 CDK1 P06493 human PITPNM1 9600 O00562 PITPNM1 human S382 451453 DFIDAFAsPVEAEGt X X +CDK1 CDK1 P06493 human TTDN1 136647 Q8TAP9 MPLKIP human S93 478365 YPGSYsrsPAGsQQQ X +CDK1 CDK1 P06493 human NuaK1 9891 O60285 NUAK1 human S445 2023457 TGVLLPssPEAEVPG X +CDK1 CDK1 P06493 human Caldesmon 373965 P12957 CALD1 chicken T688 448467 SsPGGTGtPNKEtAG Caldesmon X +CDK1 CDK1 P06493 human PEX14 64460 Q642G4 Pex14 rat S232 455420 NRRQFPPsPSAPKIP X +CDK1 CDK1 P06493 human HMGA1 3159 P17096 HMGA1 human S36 455950 PRkQPPVsPGtALVG X +CDK1 CDK1 P06493 human NUDE1 iso1 54820 Q9NXR1-1 NDE1 human T246 467025 stGGtPLtPAARISA NUDE_C X X +CDK1 CDK1 P06493 human CDC27 996 P30260 CDC27 human S312 455855 PPVIDVPstGAPSKk X +CDK1 CDK1 P06493 human RRM2 6241 P31350 RRM2 human S20 457399 DPQQLQLsPLkGLsL X +CDK1 CDK1 P06493 human NCL 4691 P19338 NCL human T641 21697920 EIDGNkVtLDWAkPK RRM_1 X X +CDK1 CDK1 P06493 human OSBP2 23762 Q969R2 OSBP2 human S766 15721694 VMHssPssPsSDGKQ Oxysterol_BP X +CDK1 CDK1 P06493 human ECT2 1894 Q9H8V3 ECT2 human T444 457522 TKSSKSStPVPskQS X +CDK1 CDK1 P06493 human NPM1 4869 P06748 NPM1 human T199 448515 VkKsIrDtPAkNAQK X X 3541; 75984 +CDK1 CDK1 P06493 human LIG3 3980 P49916 LIG3 human S210 468127 TttGQVtsPVkGAsF X +CDK1 CDK1 P06493 human BRCA1 672 P38398 BRCA1 human S1497 448730 EPGVERssPsKCPsL X X +CDK1 CDK1 P06493 human RAB5B 5869 P61020 RAB5B human S123 457392 kELQRQAsPsIVIAL Ras X +CDK1 CDK1 P06493 human LDH-A 3939 P00338 LDHA human T248 3883800 VIkLkGYtsWAIGLS Ldh_1_C X +CDK1 CDK1 P06493 human NUCKS 64710 Q9H1E3 NUCKS1 human S181 452956 LkAtVtPsPVkGkGk X +CDK1 CDK1 P06493 human BRCA1 672 P38398 BRCA1 human S1189 450007 QKGELsRsPsPFtHT X X +CDK1 CDK1 P06493 human TPX2 22974 Q9ULW0 TPX2 human S738 453052 QPLtVPVsPkFsTRF X +CDK1 CDK1 P06493 human Jun 24516 P17325 Jun rat S63 447686 KNSDLLtsPDVGLLK Jun X 5464; 9261; 2361; 97721; 91952 +CDK1 CDK1 P06493 human desmin 13346 P31001 Des mouse S7 466342 _MSQAYsssQRVSSY X +CDK1 CDK1 P06493 human Rab4 5867 P20338 RAB4A human S204 451289 AALRQLRsPRRAQAP X +CDK1 CDK1 P06493 human NCKAP5L 57701 Q9HCH0 NCKAP5L human S767 3213144 RVDLEPVsPRSCLTk X +CDK1 CDK1 P06493 human PHLPP 23239 O60346 PHLPP1 human S450 36134756 VAPGGLQstPGRSGV X X +CDK1 CDK1 P06493 human CDCA5 113130 Q96FF9 CDCA5 human S139 20727378 DARDLEMsKKVRRsy Sororin X X +CDK1 CDK1 P06493 human REPS2 9185 Q8NFH8 REPS2 human S463 480114 RPRsRsyssTsIEEA X +CDK1 CDK1 P06493 human IP3R1 16438 P11881 Itpr1 mouse S421 450268 VMLKIGTsPLKEDkE MIR X X +CDK1 CDK1 P06493 human RIT1 6016 Q92963 RIT1 human S209 6424741 SVWKRLKsPFRKkKD X +CDK1 CDK1 P06493 human RPS3 6188 P23396 RPS3 human T221 452652 kDEILPttPIsEQkG X X +CDK1 CDK1 P06493 human PHLPP 23239 O60346 PHLPP1 human S324 31871709 sPAPsDssPGEPFVG X X +CDK1 CDK1 P06493 human RARA 19401 P11416 Rara mouse S461 455330 RSsPATQsP______ X +CDK1 CDK1 P06493 human SPAG5 10615 Q96R06 SPAG5 human S249 460404 PSSVLWLsPSTALAA X X +CDK1 CDK1 P06493 human CDC27 996 P30260 CDC27 human S435 455862 EItkLDssIIsEGkI X +CDK1 CDK1 P06493 human ACSL4 2182 O60488 ACSL4 human S447 23079030 LSGGAPLsPQTHRFM AMP-binding X X +CDK1 CDK1 P06493 human kindlin-2 10979 Q96AC1 FERMT2 human S181 3208614 GsGsIyssPGLyskT X X +CDK1 CDK1 P06493 human MASTL 84930 Q96GX5 MASTL human T194 3209097 NMMDILTtPSMAkPR Pkinase X +CDK1 CDK1 P06493 human GRP58 2923 P30101 PDIA3 human S456 3963114 GFPtIyFsPANkKLN Thioredoxin X +CDK1 CDK1 P06493 human PIK3C3 5289 Q8NEB9 PIK3C3 human T159 14659500 DGSEPTktPGRtssT PI3K_C2 X X +CDK1 CDK1 P06493 human Calnexin 29144 P35565 Canx rat S582 449100 EDEILNRsPRNRKPR X +CDK1 CDK1 P06493 human lamin A/C 4000 P02545 LMNA human S22 452604 QAsstPLsPtRItRL X X 2026; 13448 +CDK1 CDK1 P06493 human FLNA 2316 P21333 FLNA human S1084 452265 LQGGsAGsPArFtID Filamin X +CDK1 CDK1 P06493 human AML1 iso8 861 Q01196-8 RUNX1 human S303 454401 VHPAtPIsPGRASGM X +CDK1 CDK1 P06493 human KIF20B 9585 Q96Q89 KIF20B human T1644 10783141 VKHPGCttPVtVKIP X +CDK1 CDK1 P06493 human JARID1B 10765 Q9UGL1 KDM5B human S1456 15404114 FkLERERsYELVRSA X X +CDK1 CDK1 P06493 human AML3 860 Q13950 RUNX2 human S465 460684 MVPGGDRsPSRMLPP RunxI X X +CDK1 CDK1 P06493 human Chk1 12649 O35280 Chek1 mouse S286 465527 TsGGMSEsSSGFSKH X +CDK1 CDK1 P06493 human Bcl-2 596 P10415 BCL2 human S87 448396 AAAGPALsPVPPVVH X +CDK1 CDK1 P06493 human p27Kip1 1027 P46527 CDKN1B human T187 447875 NAGsVEQtPKKPGLR X +CDK1 CDK1 P06493 human TAZ 25937 Q9GZV5 WWTR1 human S105 3211881 tGAGAAGsPAQQHAH X X +CDK1 CDK1 P06493 human BAD 12015 Q61337 Bad mouse S128 447861 EGMEEELsPFRGRsR Bcl-2_BAD X +CDK1 CDK1 P06493 human p70S6K 83840 P67999 Rps6kb1 rat S441 450015 sPRRFIGsPRtPVsP X +CDK1 CDK1 P06493 human TOP2A 7153 P11388 TOP2A human S1361 455094 sPPKTKtsPKLsNkE X +CDK1 CDK1 P06493 human RAD9A 5883 Q99638 RAD9A human S328 449812 VLPsIsLsPGPQPPK X X +CDK1 CDK1 P06493 human RANBP2 5903 P49792 RANBP2 human T2153 3191215 LLDIPLQtPHkLVDt X +CDK1 CDK1 P06493 human kindlin-2 10979 Q96AC1 FERMT2 human S186 15226813 yssPGLyskTMTPty X X +CDK1 CDK1 P06493 human Wee1 7465 P30291 WEE1 human S123 451132 EEGFGsSsPVKsPAA X +CDK1 CDK1 P06493 human MCL1 4170 Q07820 MCL1 human T92 4825134 EVPDVTAtPARLLFF X X +CDK1 CDK1 P06493 human CDCA5 113130 Q96FF9 CDCA5 human S33 472118 LRRsQRKsGsELPsI X X +CDK1 CDK1 P06493 human BARD1 580 Q99728 BARD1 human S251 455769 sQPSVISsPQINGEI X +CDK1 CDK1 P06493 human FLNA 2316 P21333 FLNA human S1533 478649 GDEEVPRsPFKVkVL Filamin X +CDK1 CDK1 P06493 human SP1 6667 P08047 SP1 human T723 36897201 GVALsVGtLPLDsGA X X +CDK1 CDK1 P06493 human SMAD2 Q1W668 SMAD2 cow S255 448796 ELsPTTLsPVNHSLD X +CDK1 CDK1 P06493 human VGLL4 iso4 9686 Q14135-4 VGLL4 human S58 478547 RTGPPPIsPSKRKFS VGLL4 X X +CDK1 CDK1 P06493 human PHLPP 23239 O60346 PHLPP1 human S336 27454806 FVGGPVssPRAPRPV X X +CDK1 CDK1 P06493 human NPM1 25498 P13084 Npm1 rat S70 459898 EAMNyEGsPIKVTLA Nucleoplasmin X +CDK1 CDK1 P06493 human PRDX1 5052 Q06830 PRDX1 human T90 455554 CHLAWVNtPkkQGGL AhpC-TSA X X +CDK1 CDK1 P06493 human RAD9A 5883 Q99638 RAD9A human S277 449811 SHsQDLGsPERHQPV X X +CDK1 CDK1 P06493 human NCKAP5L 57701 Q9HCH0 NCKAP5L human S451 483854 AQGPLLPsPARGLKF X +CDK1 CDK1 P06493 human PTP1B 5770 P18031 PTPN1 human S386 447810 LrGAQAAsPAKGEPs X +CDK1 CDK1 P06493 human SPAG5 10615 Q96R06 SPAG5 human S135 460403 KTIVLVPsPLGQQQD X X +CDK1 CDK1 P06493 human APRIN 23047 Q9NTI5 PDS5B human T1370 467472 AIEstQstPQKGRGR X +CDK1 CDK1 P06493 human Tau iso8 4137 P10636-8 MAPT human S202 447928 sGyssPGsPGtPGsR X 39357; 30505 +CDK1 CDK1 P06493 human ECT2 1894 Q9H8V3 ECT2 human T373 456870 VsMLsLNtPNsNRKR X X +CDK1 CDK1 P06493 human KPNA2 3838 P52292 KPNA2 human T9 11536044 stNENANtPAARLHR X X +CDK1 CDK1 P06493 human MYPT1 116670 Q10728 Ppp1r12a rat S601 3545005 AKTPPGSsPAGTQSS X +CDK1 CDK1 P06493 human STIM1 6786 Q13586 STIM1 human S668 484156 IGEEtDssPGRKKFP X +CDK1 CDK1 P06493 human PKM 5315 P14618 PKM human S37 476070 MCRLDIDsPPItARN X X +CDK1 CDK1 P06493 human UHRF1 29128 Q96T88 UHRF1 human S639 471011 QQEGGFAsPRTGkGk X X +CDK1 CDK1 P06493 human ATG13 9776 O75143 ATG13 human S224 53377101 DRPYPSSsPMHPCNY X +CDK1 CDK1 P06493 human epsin 1 29924 Q9Y6I3 EPN1 human S382 3178200 FSDPWGGsPAKPSTN X +CDK1 CDK1 P06493 human DENR 8562 O43583 DENR human T69 476008 PNEFAKLtVENsPKQ X +CDK1 CDK1 P06493 human ZNF261 9203 Q14202 ZMYM3 human T826 3801541 PPPPPPAtPRKNKAA X +CDK1 CDK1 P06493 human kindlin-2 10979 Q96AC1 FERMT2 human S175 3208608 GPLItPGsGsIyssP X X +CDK1 CDK1 P06493 human MEK1 170851 Q01986 Map2k1 rat T292 448287 EtPPRPRtPGRPLsS Pkinase X 26975 +CDK1 CDK1 P06493 human p21Cip1 1026 P38936 CDKN1A human S130 455618 sGEQAEGsPGGPGDs X X +CDK1 CDK1 P06493 human EML3 256364 Q32P44 EML3 human T881 483690 GAGPAPAtPsRtPsL X X +CDK1 CDK1 P06493 human APC1 64682 Q9H1A4 ANAPC1 human S373 455826 VQRFNIssHNQsPkR X +CDK1 CDK1 P06493 human TPR 7175 P12270 TPR human S2073 468981 QAPRAPQsPRRPPHP X X +CDK1 CDK1 P06493 human TOP2B 7155 Q02880 TOP2B human S1424 3194111 DKDEytFsPGKsKAt X +CDK1 CDK1 P06493 human NDEL1 81565 Q9GZM8 NDEL1 human T245 3211851 GFGtsPLtPSARISA NUDE_C X +CDK1 CDK1 P06493 human INCENP 16319 Q9WU62 Incenp mouse T388 458333 ATKIAIStPTSKPAA X +CDK1 CDK1 P06493 human RRM2 20135 P11157 Rrm2 mouse S20 457399 DQQQLQLsPLKRLTL X +CDK1 CDK1 P06493 human OGFR 11054 Q9NZT2 OGFR human S378 2906773 EDRPEPLsPKEsKKR X +CDK1 CDK1 P06493 human DNCLI1 420668 Q90828 DYNC1LI1 chicken S197 454199 PGEDFPAsPQRRNTS DLIC X +CDK1 CDK1 P06493 human RECQL4 9401 O94761 RECQL4 human S251 25173044 EVSIRVGsPQPSSSG X X +CDK1 CDK1 P06493 human RGPD3 653489 A6NKT7 RGPD3 human S1276 3963101 HAsPLAssPVRKNLF X +CDK1 CDK1 P06493 human RAD9A 5883 Q99638 RAD9A human S336 449816 PGPQPPKsPGPHsEE X X +CDK1 CDK1 P06493 human PHF8 23133 Q9UPP1 PHF8 human S120 453946 GKPVkTGsPtFVREL X +CDK1 CDK1 P06493 human APC1 64682 Q9H1A4 ANAPC1 human S547 455831 PLsKLLGsLDEVVLL X +CDK1 CDK1 P06493 human APC1 64682 Q9H1A4 ANAPC1 human S688 452953 FDFEGsLsPVIAPkk Apc1_MidN X +CDK1 CDK1 P06493 human ECT2 1894 Q9H8V3 ECT2 human T846 457521 RAFsFsktPKRALRR X X +CDK1 CDK1 P06493 human DDHD1 80821 Q8NEL9 DDHD1 human S11 22351356 PGrGsPRsPEHNGRG X +CDK1 CDK1 P06493 human EZH2 2146 Q15910 EZH2 human T487 452848 APAEDVDtPPRKKKR X X +CDK1 CDK1 P06493 human CDC25C 398119 P30309 cdc25c-b frog T67 448420 LSTFSGEtPKRCLDL X +CDK1 CDK1 P06493 human SIRT3 23410 Q9NTG7 SIRT3 human T150 41655507 MVGAGIStPSGIPDF SIR2 X X +CDK1 CDK1 P06493 human hnRNP K 117282 P61980 Hnrnpk rat S216 450148 ILDLISEsPIkGRAQ X +CDK1 CDK1 P06493 human LRRK1 79705 Q38SD2 LRRK1 human T1427 41694202 GALGVEGtPGyQAPE Pkinase X +CDK1 CDK1 P06493 human RNMT 8731 O43148 RNMT human T77 454561 SSSCGKDtPsKKRKL X X +CDK1 CDK1 P06493 human NUP98 iso2 4928 P52948-2 NUP98 human T529 3149520 AAQKALttPTHYKLt X +CDK1 CDK1 P06493 human p70S6K 6198 P23443 RPS6KB1 human S394 448806 TRQtPVDsPDDStLS Pkinase_C X 9208 +CDK1 CDK1 P06493 human NOLC1 9221 Q14978 NOLC1 human T610 451912 IkLQtPNtFPKRKKG X +CDK1 CDK1 P06493 human AHNAK 79026 Q09666 AHNAK human S5763 483522 EAEAEAssPkGKFsL X +CDK1 CDK1 P06493 human ULK1 22241 O70405 Ulk1 mouse S629 27460648 sPtKAGPsFDFPKtP X +CDK1 CDK1 P06493 human PSMA5 5686 P28066 PSMA5 human S16 483589 DrGVNtFsPEGrLFQ Proteasome_A_N X +CDK1 CDK1 P06493 human CDC27 996 P30260 CDC27 human T205 455848 PEtVLtEtPQDtIEL X +CDK1 CDK1 P06493 human MCM3 17215 P25206 Mcm3 mouse S611 2840506 SSDTARTsPVTARTL MCM_lid X +CDK1 CDK1 P06493 human ASE-1 10849 O15446 POLR1G human S285 453847 PLEDtVLsPtKKRKR X +CDK1 CDK1 P06493 human lamin A/C 60374 P48679 Lmna rat S22 452604 QASStPLsPTRITRL X 2026; 13448 +CDK1 CDK1 P06493 human NUDE1 iso1 54820 Q9NXR1-1 NDE1 human T243 469634 LDDstGGtPLtPAAR NUDE_C X +CDK1 CDK1 P06493 human NDUFV3 4731 P56181 NDUFV3 human S105 4751741 QPssGREsPRH____ X X +CDK1 CDK1 P06493 human SGO1 151648 Q5FBB7 SGO1 human T346 15406076 LEEGVHLtPFRQKVS X X +CDK1 CDK1 P06493 human PHF8 23133 Q9UPP1 PHF8 human S69 15108901 CQDWFHGsCVGVEEE PHD X +CDK1 CDK1 P06493 human RAMP 51514 Q9NZJ0 DTL human T464 4717290 DLPLPsNtPTFSIKt X X +CDK1 CDK1 P06493 human CDC25C 995 P30307 CDC25C human S214 448417 sRsGLyRsPsMPENL M-inducer_phosp X X +CDK1 CDK1 P06493 human EEF2K 29904 O00418 EEF2K human S359 447826 GtEEKCGsPQVRtLs X X +CDK1 CDK1 P06493 human NUSAP1 51203 Q9BXS6 NUSAP1 human T300 7989914 HKRsLtKtPARksAH NUSAP X X +CDK1 CDK1 P06493 human DEPDC1 55635 Q5TB30 DEPDC1 human S110 31082615 LFRFPAtsPLkTLPR X X +CDK1 CDK1 P06493 human SKA3 221150 Q8IX90 SKA3 human T203 1869388600 sLVkVLKtPKCALkM X +CDK1 CDK1 P06493 human PIK3C2A 5286 O00443 PIK3C2A human S259 449059 kVSNLQVsPkSEDIS X X +CDK1 CDK1 P06493 human KIFC1 3833 Q9BW19 KIFC1 human S26 477789 RPLIkAPsQLPLsGs X +CDK1 CDK1 P06493 human SSR1 6745 P43307 SSR1 human S268 3072271 LNQINkAsPRRLPRK TRAP_alpha X +CDK1 CDK1 P06493 human p70S6K 83840 P67999 Rps6kb1 rat S434 448356 SFEPKIRsPRRFIGs X +CDK1 CDK1 P06493 human HIF1A 3091 Q16665 HIF1A human S668 11073382 DTQSRTAsPNRAGkG X +CDK1 CDK1 P06493 human Lamin B1 4001 P20700 LMNB1 human S23 455421 GGPttPLsPtRLsRL X +CDK1 CDK1 P06493 human E2F1 1869 Q01094 E2F1 human S332 447868 TDSATIVsPPPSsPP X +CDK1 CDK1 P06493 human TEX14 56155 Q8IWB6 TEX14 human T618 25158902 EEASSPStGQPSLCS X +CDK1 CDK1 P06493 human XIAP 331 P98170 XIAP human S40 31884865 FANFPSGsPVSAstL BIR X +CDK1 CDK1 P06493 human VGLL4 iso4 9686 Q14135-4 VGLL4 human S155 3195941 ASRPAGLsPTLtPGE VGLL4 X X +CDK1 CDK1 P06493 human BUB1B 701 O60566 BUB1B human S1043 483373 WkVGkLtsPGALLFQ X +CDK1 CDK1 P06493 human BARD1 580 Q99728 BARD1 human T299 455768 KSRNEVVtPEKVCkN X +CDK1 CDK1 P06493 human DDHD1 80821 Q8NEL9 DDHD1 human S727 465585 TIPsPVtsPVLSRRH DDHD X +CDK1 CDK1 P06493 human CUTL1 13047 P53564 Cux1 mouse S1232 456479 IDYSQGAsPQPQHQL X +CDK1 CDK1 P06493 human CDCA5 113130 Q96FF9 CDCA5 human S209 3208965 DMtLPGIsPPPEKQK Sororin X X +CDK1 CDK1 P06493 human SLX4 84464 Q8IY92 SLX4 human T1544 1880104206 QKPEGLEtPKGANRK X +CDK1 CDK1 P06493 human ERK3 5597 Q16659 MAPK6 human T698 13830502 kSIQATLtPSAMkss X X +CDK1 CDK1 P06493 human UBE2A 7319 P49459 UBE2A human S120 448007 LDEPNPNsPANSQAA UQ_con X X +CDK1 CDK1 P06493 human RECQL5 9400 O94762 RECQL5 human S727 4767154 sAHYGGPsPEKKAKS RecQ5 X X +CDK1 CDK1 P06493 human kindlin-1 55612 Q9BQL6 FERMT1 human S174 3210720 LEssPTAsGsSVsPG X +CDK1 CDK1 P06493 human HMGA1 117062 Q8K585 Hmga1 rat T78 451516 KTRKVTTtPGRKPRG X +CDK1 CDK1 P06493 human FOXM1 iso2 2305 Q08050-2 FOXM1 human T596 451437 ETLPISStPSKSVLP X X +CDK1 CDK1 P06493 human TAZ 25937 Q9GZV5 WWTR1 human T326 41594201 GCySVPTtPEDFLSN X X +CDK1 CDK1 P06493 human CDC25C 995 P30307 CDC25C human T48 448419 VCPDVPRtPVGkFLG X 9527; 12028 +CDK1 CDK1 P06493 human SRC-3 8202 Q9Y6Q9 NCOA3 human S867 454107 sPVsVGssPPVKNIS X +CDK1 CDK1 P06493 human CK2B 1460 P67870 CSNK2B human S209 451751 QAAsNFksPVktIR_ X +CDK1 CDK1 P06493 human Wee1 7465 P30291 WEE1 human S139 449250 yFLGSsFsPVRCGGP X +CDK1 CDK1 P06493 human MEK1 170851 Q01986 Map2k1 rat T286 448286 VEGDAAEtPPRPRtP Pkinase X 9127 +CDK1 CDK1 P06493 human TFPT 29844 P0C1Z6 TFPT human S180 451482 PAPPEPGsPAPGEGP X +CDK1 CDK1 P06493 human BUB1 699 O43683 BUB1 human T609 465611 sAAQLAstPFHkLPV X +CDK1 CDK1 P06493 human separase 9700 Q14674 ESPL1 human S1126 447673 IAPStNSsPVLKTKP X +CDK1 CDK1 P06493 human TSC1 7248 Q92574 TSC1 human T417 450279 SLPQATVtPPRKEER Hamartin X X +CDK1 CDK1 P06493 human FEN1 2237 P39748 FEN1 human S187 2708400 MDCLTFGsPVLMrHL XPG_I X X +CDK1 CDK1 P06493 human KIF20A 10112 O95235 KIF20A human T198 32007200 LQGQLHPtPDLKPLL Kinesin X +CDK1 CDK1 P06493 human BAG3 9531 O95817 BAG3 human T285 467534 GsPARsstPLHsPsP X X +CDK1 CDK1 P06493 human ATAD5 79915 Q96QE3 ATAD5 human S653 3209715 TVPFDsEsPIRMKFt X +CDK1 CDK1 P06493 human CK2A1 1457 P68400 CSNK2A1 human S370 449987 PLGPLAGsPVIAAAN X +CDK1 CDK1 P06493 human SLX4 84464 Q8IY92 SLX4 human T1571 1880104210 PQYSIMEtPVLkKEL X +CDK1 CDK1 P06493 human PKN1 5585 Q16512 PKN1 human S562 483683 LGtDsDssPQkSSRD X X +CDK1 CDK1 P06493 human DDX3 1654 O00571 DDX3X human T204 457783 LTRyTRPtPVQkHAI DEAD X X +CDK1 CDK1 P06493 human ERCC6 2074 Q03468 ERCC6 human T1031 1875831800 GTGSDVQtPKCHLKR X +CDK1 CDK1 P06493 human U2AF2 11338 P26368 U2AF2 human S79 470379 EHGGLIRsPRHEKKK X +CDK1 CDK1 P06493 human UBXN2B 137886 Q14CS0 UBXN2B human T59 3217944 TVFksPRtPPQRFys X +CDK1 CDK1 P06493 human PHLPP 23239 O60346 PHLPP1 human S317 25172982 GGWsRRAsPAPsDss X X +CDK1 CDK1 P06493 human NCAPG 64151 Q9BPX3 NCAPG human T931 471738 KNKEVyMtPLrGVkA X +CDK1 CDK1 P06493 human LBR 3930 Q14739 LBR human S71 450689 KGGsTsSsPSRRRGS X +CDK1 CDK1 P06493 human DISC1 244667 Q811T9 Disc1 mouse S710 18942700 QLQEAGSsPHAEDEE X +CDK1 CDK1 P06493 human CDC27 996 P30260 CDC27 human S222 455850 LNLEssNsKYSLNTD X +CDK1 CDK1 P06493 human 4E-BP1 1978 Q13541 EIF4EBP1 human T70 447528 rNsPVtktPPRDLPt eIF_4EBP X 9455; 13396 +CDK1 CDK1 P06493 human EPB41 iso2 2035 P11171-2 EPB41 human S679 467260 DKRLSTHsPFRTLNI SAB X +CDK1 CDK1 P06493 human DISC1 27185 Q9NRI5 DISC1 human S713 18942700 QLQEARGsLSVEDER X +CDK1 CDK1 P06493 human STI1 20867 Q60864 Stip1 mouse T198 465576 DEEEEAAtPPPPPPP X +CDK1 CDK1 P06493 human NSFL1C 55968 Q9UNZ2 NSFL1C human S140 455619 AVERVTksPGETSkP X X +CDK1 CDK1 P06493 human MEK1 5604 Q02750 MAP2K1 human T286 448286 VEGdAAEtPPRPRtP Pkinase X X 9127 +CDK1 CDK1 P06493 human NUDE1 iso1 54820 Q9NXR1-1 NDE1 human T191 20722719 QKQEKPRtPMPSSVE NUDE_C X +CDK1 CDK1 P06493 human FANCG 2189 O15287 FANCG human S387 454240 PRFsPPPsPPGPCMP X +CDK1 CDK1 P06493 human DAB2IP iso2 153090 Q5VWQ8-2 DAB2IP human T531 1875342306 DVHTALStPGSGQLP DUF3498 X +CDK1 CDK1 P06493 human INCENP 16319 Q9WU62 Incenp mouse T59 458332 EPELMPKtPSQKNRR X +CDK1 CDK1 P06493 human DLG1 1739 Q12959 DLG1 human S158 2024309 FVsHsHIsPIKPTEA MAGUK_N_PEST X X +CDK1 CDK1 P06493 human NCKAP5L 57701 Q9HCH0 NCKAP5L human S577 3213141 PsPEPPPsPLQVPTY X +CDK1 CDK1 P06493 human KIF20A 10112 O95235 KIF20A human T857 471862 LRNLLPRtPtCQsst X +CDK1 CDK1 P06493 human U2AF2 308335 F2Z3T9 U2af2 rat S79 470379 EHGGLIRsPRHEKKK X +CDK1 CDK1 P06493 human SKA3 221150 Q8IX90 SKA3 human T217 3205641 MDDFECVtPKLEHFG X +CDK1 CDK1 P06493 human GRASP65 56082 O35254 Gorasp1 rat T224 4768154 SPGtPAKtPQPNAFP X +CDK1 CDK1 P06493 human POLR2A 5430 P24928 POLR2A human S1934 452275 sPtysPtsPKGSTYs X +CDK1 CDK1 P06493 human RFA2 6118 P15927 RPA2 human S33 448339 GFGsPAPsQAEkkSR X 10148 +CDK1 CDK1 P06493 human PKN1 5585 Q16512 PKN1 human S916 452442 TGEAPtLsPPRDARP Pkinase_C X X +CDK1 CDK1 P06493 human SET 6418 Q01105 SET human S7 455972 _MAPKRQsPLPPQKK X X +CDK1 CDK1 P06493 human APC4 29945 Q9UJX5 ANAPC4 human S779 455839 kEEVLsEsEAENQQA X +CDK1 CDK1 P06493 human CEP55 55165 Q53EZ4 CEP55 human S425 457628 NREKVAAsPksPtAA X +CDK1 CDK1 P06493 human TRF1 7013 P54274 TERF1 human T344 3793900 KKERRVGtPQsTKKK X +CDK1 CDK1 P06493 human PRPS1 5631 P60891 PRPS1 human S103 56655989 RQDKKDKsRAPISAK Pribosyltran_N X X +CDK1 CDK1 P06493 human BLM 641 P54132 BLM human T766 469111 IIKLLYVtPEkICAs DEAD X +CDK1 CDK1 P06493 human GAPVD1 26130 Q14C86 GAPVD1 human S950 483086 APHsssssPsKDssR X +CDK1 CDK1 P06493 human NPM1 4869 P06748 NPM1 human S70 459898 EAMNyEGsPIkVtLA Nucleoplasmin X +CDK1 CDK1 P06493 human NEDD1 121441 Q8NHV4 NEDD1 human S460 20609205 STSVLHSsPLNVFMG X X +CDK1 CDK1 P06493 human GJA1 2697 P17302 GJA1 human S262 450694 sPAkDCGsQkyAyFN X +CDK1 CDK1 P06493 human NME2 4831 P22392 NME2 human T94 3182029 GrVMLGEtNPADskP NDK X +CDK1 CDK1 P06493 human WAC 51322 Q9BTA9 WAC human T482 469446 ssQPKVStPVVkQGP X X +CDK1 CDK1 P06493 human NICE-4 9898 Q14157 UBAP2L human S454 452474 AAPPPPssPLPsKst X +CDK1 CDK1 P06493 human RAB11FIP3 9727 O75154 RAB11FIP3 human S102 25126702 GPRGQLAsPDAPGPG X +CDK1 CDK1 P06493 human HJURP 55355 Q8NCD3 HJURP human S448 3206595 LHREyCLsPRNQPRR HJURP_C X +CDK1 CDK1 P06493 human CDCA5 113130 Q96FF9 CDCA5 human T48 472119 LPEIWPKtPsAAAVR X X +CDK1 CDK1 P06493 human NME1 4830 P15531 NME1 human T94 3180917 GrVMLGEtNPADskP NDK X +CDK1 CDK1 P06493 human APC1 64682 Q9H1A4 ANAPC1 human T291 455824 kFsEQGGtPQNVATS X +CDK1 CDK1 P06493 human CASP8 841 Q14790 CASP8 human S387 16855100 yLEMDLSsPQTRYIP Peptidase_C14 X X +CDK1 CDK1 P06493 human SUN1 iso9 23353 O94901-9 SUN1 human S333 17861021 HTAAHSQsPRLPGRA MRP X X +CDK1 CDK1 P06493 human TFCP2L1 29842 Q9NZI6 TFCP2L1 human T177 38489957 HCISTEFtPRKHGGE CP2 X +CDK1 CDK1 P06493 human kindlin-2 10979 Q96AC1 FERMT2 human S177 4760248 LItPGsGsIyssPGL X X +CDK1 CDK1 P06493 human dUTPase 1854 P33316 DUT human S99 451166 GPEtPAIsPSKRARP X +CDK1 CDK1 P06493 human EGFR 1956 P00533 EGFR human S1026 451640 PQQGFFssPSTsRtP X +CDK1 CDK1 P06493 human MARK2 2011 Q7KZI7 MARK2 human S619 455400 PyGVtPAsPsGHsQG X +CDK1 CDK1 P06493 human PHLPP 23239 O60346 PHLPP1 human S425 23131538 KAPRAIDsPGGAVRE X X +CDK1 CDK1 P06493 human RFA2 6118 P15927 RPA2 human S23 448337 GAGGYtQsPGGFGsP X +CDK1 CDK1 P06493 human ID2 3398 Q02363 ID2 human S5 451265 ___MKAFsPVRSVRk X +CDK1 CDK1 P06493 human IP3R1 16438 P11881 Itpr1 mouse T799 450269 RDPQEQVtPVKYARL X X +CDK1 CDK1 P06493 human PITPNM1 9600 O00562 PITPNM1 human T287 451454 SAASNTGtPDGPEAP X +CDK1 CDK1 P06493 human PEX14 5195 O75381 PEX14 human S232 455420 NRRQFPPsPsAPKIP X +CDK1 CDK1 P06493 human SRC-3 8202 Q9Y6Q9 NCOA3 human S728 3217881 VVkQEQLsPKKKENN DUF4927 X X +CDK1 CDK1 P06493 human NCKAP5L 57701 Q9HCH0 NCKAP5L human S470 31863313 PTSEKsPsPGGPQLs X +CDK1 CDK1 P06493 human DRP1 10059 O00429 DNM1L human S616 454690 PIPIMPAsPQKGHAV X X 3455; 4494; 63940 +CDK1 CDK1 P06493 human RCC1 1104 P18754 RCC1 human S11 452007 KRIAKRRsPPADAIP X 4210; 5500 +CDK1 CDK1 P06493 human JunB 24517 P24898 Junb rat S23 1814002 AAAGYGRsPGSLSLH Jun X X +CDK1 CDK1 P06493 human TAZ 25937 Q9GZV5 WWTR1 human S90 4777166 QHVRsHssPAsLQLG X X +CDK1 CDK1 P06493 human RECQL4 9401 O94761 RECQL4 human S89 25173042 LNRAATKsPQStPGR Drc1-Sld2 X X +CDK1 CDK1 P06493 human PKR 5610 P19525 EIF2AK2 human S456 3181637 KGtLRyMsPEQISSQ Pkinase X +CDK1 CDK1 P06493 human STMN1 29332 P13668 Stmn1 rat S25 448555 QAFELILsPRSKESV Stathmin X +CDK1 CDK1 P06493 human Nlp 22981 Q9Y2I6 NINL human S185 15668109 WDSEDFGsPQKSCsP X +CDK1 CDK1 P06493 human HMGA1 3159 P17096 HMGA1 human T53 451515 kEPsEVPtPkRPrGr X +CDK1 CDK1 P06493 human BAG3 9531 O95817 BAG3 human S289 469169 RsstPLHsPsPIRVH X +CDK1 CDK1 P06493 human EZH2 14056 Q61188 Ezh2 mouse T487 452848 VPTEDVDtPPRKKKR X +CDK1 CDK1 P06493 human CDC7 8317 O00311 CDC7 human T376 2864203 QVAPRAGtPGFRAPE Pkinase X +CDK1 CDK1 P06493 human CDCA5 113130 Q96FF9 CDCA5 human S83 3208977 PRRsPRIsFFLEKEN X X +CDK1 CDK1 P06493 human TPP1 1200 O14773 TPP1 human T201 3963104 VGLHLGVtPSVIRKR X +CDK1 CDK1 P06493 human HuR 1994 Q15717 ELAVL1 human S202 3197192 LLsQLyHsPArrFGG X X +CDK1 CDK1 P06493 human NOLC1 64896 P41777 Nolc1 rat T615 451912 VKLQtPNtFPKRKKG X +CDK1 CDK1 P06493 human JARID1B 10765 Q9UGL1 KDM5B human S1328 15411230 NRTSYLHsPFSTGRS X +CDK1 CDK1 P06493 human AAK1 500244 P0C1X8 Aak1 rat T388 483910 LPIQPALtPRKRATV X +CDK1 CDK1 P06493 human ULK1 22241 O70405 Ulk1 mouse S637 3176158 FDFPKtPssQNLLTL X 14205 +CDK1 CDK1 P06493 human NME1 191575 Q05982 Nme1 rat T94 3180917 GRVMLGEtNPADskP NDK X +CDK1 CDK1 P06493 human SAS6 163786 Q6UVJ0 SASS6 human S510 483310 NTIRsGIsPNLNVVD X X +CDK1 CDK1 P06493 human BAG3 9531 O95817 BAG3 human S291 467532 stPLHsPsPIRVHTV X +CDK1 CDK1 P06493 human CDC27 996 P30260 CDC27 human T329 455857 ARIGQTGtkSVFsQs X +CDK1 CDK1 P06493 human Bcl-2 596 P10415 BCL2 human T69 448398 SRDPVARtsPLQtPA X +CDK1 CDK1 P06493 human Abi-1 10006 Q8IZP0 ABI1 human S216 3205884 VPNDyMtsPARLGsQ X X +CDK1 CDK1 P06493 human MCM2 17216 P97310 Mcm2 mouse S27 452310 IsDPLtssPGRsSRR X X +CDK1 CDK1 P06493 human Caldesmon 373965 P12957 CALD1 chicken S682 448464 EKGNVFSsPGGTGtP Caldesmon X +CDK1 CDK1 P06493 human NONO 53610 Q99K48 Nono mouse T15 18013091 NLEKQNHtPRKHHQH X +CDK1 CDK1 P06493 human INCENP 3619 Q9NQS7 INCENP human T59 458332 EPELMPKtPSQKNRR X +CDK1 CDK1 P06493 human RANBP2 5903 P49792 RANBP2 human S2276 452314 FsFksALsPsKsPAk X +CDK1 CDK1 P06493 human OSBP2 23762 Q969R2 OSBP2 human S768 15721697 HssPssPsSDGKQKT Oxysterol_BP X +CDK1 CDK1 P06493 human TOP1 7150 P11387 TOP1 human S394 2721303 SKDAkVPsPPPGHkW Topoisom_I_N X +CDK1 CDK1 P06493 human EIF4G2 1982 P78344 EIF4G2 human T508 449145 AQPPrtQtPPLGQtP X +CDK1 CDK1 P06493 human TOP2A 7153 P11388 TOP2A human S1354 452240 DFVPsDAsPPKTKts X +CDK1 CDK1 P06493 human Rb 5925 P06400 RB1 human T373 447982 VNVIPPHtPVRTVMN RB_A X +CDK1 CDK1 P06493 human SEPT9 iso2 10801 Q9UHD8-2 SEPTIN9 human T24 469506 EVETPNStPPRRVQT X X +CDK1 CDK1 P06493 human CKAP2 26586 Q8WWK9 CKAP2 human T623 460436 FkELkFLtPVRRsRR CKAP2_C X X +CDK1 CDK1 P06493 human p70S6K 6198 P23443 RPS6KB1 human S434 448356 sFEPKIRsPRRFIGs X +CDK1 CDK1 P06493 human CEP55 55165 Q53EZ4 CEP55 human S428 457629 KVAAsPksPtAALNE X +CDK1 CDK1 P06493 human APC1 64682 Q9H1A4 ANAPC1 human S355 455825 AALsrAHsPALGVHs X +CDK1 CDK1 P06493 human IP3R1 3708 Q14643 ITPR1 human S421 450268 VMLKIGtsPVkEDkE MIR X +CDK1 CDK1 P06493 human BUB1B 701 O60566 BUB1B human S543 4049929 LsEkKNksPPADPPR X +CDK1 CDK1 P06493 human SOD2 6648 P04179 SOD2 human S106 7577901 SIFWTNLsPNGGGEP Sod_Fe_N X X +CDK1 CDK1 P06493 human NUCKS 64709 Q9EPJ0 Nucks1 rat S181 452956 LKATVtPsPVkGKGk X +CDK1 CDK1 P06493 human CDCA5 113130 Q96FF9 CDCA5 human T159 483401 LGsAStstPGRRsCF Sororin X X +CDK1 CDK1 P06493 human WAC 51322 Q9BTA9 WAC human T471 469445 PIkPLIstPPVssQP X X +CDK1 CDK1 P06493 human Tip60 10524 Q92993 KAT5 human S90 448827 LPGsRPGsPEREVPA X X +CDK1 CDK1 P06493 human POLR2A 363633 D4A5A6 Polr2a rat S1920 452274 sPTYsPTsPKySPts RNA_pol_Rpb1_R; RNA_pol_Rpb1_R X +CDK1 CDK1 P06493 human Restin 65201 Q9JK25 Clip1 rat T286 483203 KIGFPSTtPAKAKAA X X +CDK1 CDK1 P06493 human MYST2 11143 O95251 KAT7 human T85 1823700 tRsQQQPtPVtPkKY X +CDK1 CDK1 P06493 human RCC1 1104 P18754 RCC1 human S387 2850006 GQDEDAWsPVEMMGK RCC1 X +CDK1 CDK1 P06493 human CHMP7 91782 Q8WUX9 CHMP7 human S3 54367850 _____MWsPEREAEA X +CDK1 CDK1 P06493 human TERT 7015 O14746 TERT human T249 1868023600 AAPEPERtPVGQGSW X X +CDK1 CDK1 P06493 human TTDN1 136647 Q8TAP9 MPLKIP human S104 478366 sQQQFGYsPGQQQtH MPLKIP X +CDK1 CDK1 P06493 human APC1 64682 Q9H1A4 ANAPC1 human S555 455832 LDEVVLLsPVPELRD X +CDK1 CDK1 P06493 human CDC16 8881 Q13042 CDC16 human T581 455867 TAEETGLtPLETsRK X +CDK1 CDK1 P06493 human BARD1 580 Q99728 BARD1 human S288 467302 PLAEQIEsPDTKSRN X +CDK1 CDK1 P06493 human NSBP1 79366 P82970 HMGN5 human T31 456124 sAMLVPVtPEVkPKR HMG14_17 X +CDK1 CDK1 P06493 human GRP58 29468 P11598 Pdia3 rat S456 3963114 GFPTIyFsPANKKLT Thioredoxin X +CDK1 CDK1 P06493 human KIFC1 3833 Q9BW19 KIFC1 human S6 12667678 __MDPQRsPLLEVKG X +CDK1 CDK1 P06493 human Raptor 57521 Q8N122 RPTOR human T706 11315002 ttEGGsLtPVRDsPC X X +CDK1 CDK1 P06493 human DLG7 9787 Q15398 DLGAP5 human T639 456340 GPsQRLGtPKsVNkA X +CDK1 CDK1 P06493 human PIK4CB 5298 Q9UBF8 PI4KB human S266 457619 PAPDtGLsPsKRTHQ X +CDK1 CDK1 P06493 human TRIM32 22954 Q13049 TRIM32 human S339 3195098 VVAsPRAsPAkQRGP X +CDK1 CDK1 P06493 human RGC32 28984 Q9H4X1 RGCC human T111 7105234 ALLsAtVtPQKAKLG RGCC X +CDK1 CDK1 P06493 human CDC27 996 P30260 CDC27 human S434 455861 LEItkLDssIIsEGk X +CDK1 CDK1 P06493 human Jun 24516 P17325 Jun rat S73 447943 VGLLKLAsPELERLI Jun X 9164; 3270; 8752; 12714; 77955 +CDK1 CDK1 P06493 human CLASP2 23122 O75122 CLASP2 human S1013 4753159 HSMPtHssPRsRDyN X +CDK1 CDK1 P06493 human BORA 79866 Q6PGQ7 BORA human S41 11452210 LHEQtLAsPSVFkST BORA_N X X +CDK1 CDK1 P06493 human Tau iso8 4137 P10636-8 MAPT human T212 447934 tPGsRsRtPsLPtPP X +CDK1 CDK1 P06493 human SIRT1 23411 Q96EB6 SIRT1 human T530 6006905 YLSELPPtPLHVsED X +CDK1 CDK1 P06493 human YAP1 10413 P46937 YAP1 human T143 3190678 AVsPGtLtPtGVVsG X +CDK1 CDK1 P06493 human SUN1 iso9 23353 O94901-9 SUN1 human S48 7101126 KLDPVFDsPRMSRRS X X +CDK1 CDK1 P06493 human CDC25B 994 P30305 CDC25B human S50 20503402 PVRAAASsPVttLtQ X +CDK1 CDK1 P06493 human AR 367 P10275 AR human S83 448714 QQQQQETsPRQQQQQ Androgen_recep X +CDK1 CDK1 P06493 human DLG7 9787 Q15398 DLGAP5 human T329 456337 TYQVtPMtPRsANAF GKAP X +CDK1 CDK1 P06493 human ATR 545 Q13535 ATR human S428 456320 SSNSDGIsPKRRRLs X 2853 +CDK1 CDK1 P06493 human TPX2 22974 Q9ULW0 TPX2 human T72 460008 NLQQAIVtPLkPVDN X X +CDK1 CDK1 P06493 human BRCA1 672 P38398 BRCA1 human S1191 10272402 GELsRsPsPFtHTHL X X +CDK1 CDK1 P06493 human CCNB1 891 P14635 CCNB1 human S128 448815 LVDTAsPsPMETsGC X +CDK1 CDK1 P06493 human PML 5371 P29590 PML human S518 465867 PsTSkAVsPPHLDGP DUF3583 X X +CDK1 CDK1 P06493 human FMNL2 114793 Q96PY5 FMNL2 human S1016 3209661 MEQQDPKsPsHKSKR X X +CDK1 CDK1 P06493 human VHL 7428 P40337 VHL human S80 50792657 QVIFCNrsPRVVLPV VHL X +CDK1 CDK1 P06493 human KI-67 4288 P46013 MKI67 human T1943 23117871 GskRRPQtPKEKAkA KI67R X +CDK1 CDK1 P06493 human POLR2A 363633 D4A5A6 Polr2a rat S1934 452275 sPTYsPTsPKGSTYS X +CDK1 CDK1 P06493 human dynactin 1 1639 Q14203 DCTN1 human S212 15512802 GAVPPLPsPsKEEEG X +CDK1 CDK1 P06493 human MYST2 11143 O95251 KAT7 human T88 468239 QQQPtPVtPkKYPLR X +CDK1 CDK1 P06493 human desmin 13346 P31001 Des mouse S32 466343 sLGsPLssPVFPrAG Filament_head X +CDK1 CDK1 P06493 human FOXM1 2305 Q08050 FOXM1 human T600 478080 EVGGPFKtPIkETLP X 14655 +CDK1 CDK1 P06493 human OSBP2 23762 Q969R2 OSBP2 human S763 31727226 CSKVMHssPssPsSD Oxysterol_BP X +CDK1 CDK1 P06493 human RFC1 5981 P35251 RFC1 human S518 2915402 VQGkRKIsPSKKESE X +CDK1 CDK1 P06493 human CDCA5 113130 Q96FF9 CDCA5 human T151 28750703 RsysRLEtLGsASts Sororin X X +CDK1 CDK1 P06493 human KIF4A 24137 O95239 KIF4A human T1161 459852 FFNPVCAtPNsKILK X X +CDK1 CDK1 P06493 human PTPN2 iso2 5771 P17706-2 PTPN2 human S304 451134 LSPAFDHsPNKIMTE X X +CDK1 CDK1 P06493 human CDCA5 113130 Q96FF9 CDCA5 human S164 9316471 tstPGRRsCFGFEGL Sororin X X +CDK1 CDK1 P06493 human TOB2 10766 Q14106 TOB2 human S254 14161520 PAPQSQLsPNAKEFV PAM2 X +CDK1 CDK1 P06493 human TIAM1 7074 Q13009 TIAM1 human S1466 4727743 SDAVsASsPEKESQQ X X +CDK1 CDK1 P06493 human SAMHD1 25939 Q9Y3Z3 SAMHD1 human T592 468674 DVIAPLItPQkkEWN X X 89930; 87593; 55092; 45205 +CDK1 CDK1 P06493 human SPT5 6829 O00267 SUPT5H human S666 468817 VGGFAPMsPrISsPM X +CDK1 CDK1 P06493 human CREB 1385 P16220 CREB1 human S257 14159739 PGVVMAssPALPTQP X X +CDK1 CDK1 P06493 human YAP1 10413 P46937 YAP1 human S289 3190663 PPPLAPQsPQGGVMG X X +CDK1 CDK1 P06493 human ERK3 5597 Q16659 MAPK6 human S705 13830501 tPSAMkssPQIPHQT X +CDK1 CDK1 P06493 human PBK 55872 Q96KB5 PBK human T9 451735 EGIsNFktPskLsEk X 4941 +CDK1 CDK1 P06493 human FOXO1A 56458 Q9R1E0 Foxo1 mouse S246 471071 EGGkSGksPRRRAAs X +CDK1 CDK1 P06493 human E2F1 1869 Q01094 E2F1 human S337 447869 IVsPPPSsPPSSLTT X +CDK1 CDK1 P06493 human cGAS 115004 Q8N884 CGAS human S305 36128853 MKRkRGGsPAVTLLI Mab-21 X +CDK1 CDK1 P06493 human SMAD2 Q1W668 SMAD2 cow S250 448795 TGsPAELsPTTLsPV X +CDK1 CDK1 P06493 human RAD9A 5883 Q99638 RAD9A human T292 2999204 PQLQAHStPHPDDFA X +CDK1 CDK1 P06493 human Bcl-2 596 P10415 BCL2 human T56 448655 FSSQPGHtPHPAASR X X 2875 +CDK1 CDK1 P06493 human NHERF 9368 O14745 NHERF1 human S302 468296 EELNsQDsPPKQDST EBP50_C X +CDK1 CDK1 P06493 human Calnexin 821 P27824 CANX human S583 449100 EDEILNRsPRNRKPR X +CDK1 CDK1 P06493 human NEDD1 121441 Q8NHV4 NEDD1 human T550 6225645 PPINGsstPNPKIAs X X +CDK1 CDK1 P06493 human PKN1 5585 Q16512 PKN1 human S533 483281 AtGtGTFsPGAsPGs X X +CDK1 CDK1 P06493 human USP14 9097 P54578 USP14 human T235 3192043 sssAsAAtPskkKSL UCH X +CDK1 CDK1 P06493 human GATA2 2624 P23769 GATA2 human T176 40245500 HLFGFPPtPPKEVsP X X +CDK1 CDK1 P06493 human lamin A/C 60374 P48679 Lmna rat S392 452606 ERLRLsPsPTsQRSR X +CDK1 CDK1 P06493 human Exportin-1 7514 O14980 XPO1 human S391 3174716 sPFsTsAsPLLsGsQ X X +CDK1 CDK1 P06493 human Nogo iso2 Q9JK11-2 Rtn4 rat S16 468313 LVSSSTDsPPRPPPA X +CDK1 CDK1 P06493 human TMPO iso6 7112 P42166 TMPO human S424 469953 FQETEFLsPPRkVPR X +CDK1 CDK1 P06493 human p70S6K 83840 P67999 Rps6kb1 rat T444 448358 RFIGsPRtPVsPVKF X 9204 +CDK1 CDK1 P06493 human LIMD1 8994 Q9UGP4 LIMD1 human S424 3214995 VLLDsPssPRVrLPC X X +CDK1 CDK1 P06493 human NME1 4830 P15531 NME1 human S120 450098 GRNIIhGsDsVEsAE NDK X +CDK1 CDK1 P06493 human SCML2 10389 Q9UQR0 SCML2 human S267 3216606 AsQHsMQsPQKTTLI X +CDK1 CDK1 P06493 human KIBRA 23286 Q8IX03 WWC1 human S542 25673102 sPRSsLSsPSPPCsP X X +CDK1 CDK1 P06493 human NDUFA12 55967 Q9UI09 NDUFA12 human T142 33402204 QEWIPPStPYK____ X X +CDK1 CDK1 P06493 human DYN2 1785 P50570 DNM2 human T766 452323 sAssHsPtPQRRPVS X +CDK1 CDK1 P06493 human MAP7 9053 Q14244 MAP7 human S209 460314 ssAtLLNsPDRARRL X +CDK1 CDK1 P06493 human RANBP2 5903 P49792 RANBP2 human S2251 468569 HAsPLAssPVRkNLF X +CDK1 CDK1 P06493 human NPM1 4869 P06748 NPM1 human T219 449023 kDskPsstPRskGQE X +CDK1 CDK1 P06493 human Caldesmon 373965 P12957 CALD1 chicken T711 448468 INEWLTKtPEGNKsP Caldesmon X +CDK1 CDK1 P06493 human SKA3 221150 Q8IX90 SKA3 human T360 459963 ENLLRtPtPPEVTkI X X +CDK1 CDK1 P06493 human CDCA5 113130 Q96FF9 CDCA5 human T115 469416 VPAtPtStPVPNPEA Sororin X X +CDK1 CDK1 P06493 human PTTG2 10744 Q9NZH5 PTTG2 human S165 7322915 LFQLGPPsPVKMPSP Securin X X +CDK1 CDK1 P06493 human CDCA5 113130 Q96FF9 CDCA5 human S75 470993 VEVPAVQsPRRsPRI X X +CDK1 CDK1 P06493 human NUP98 iso2 4928 P52948-2 NUP98 human T653 478067 IAKPIPQtPESAGNK X +CDK1 CDK1 P06493 human Rb 5925 P06400 RB1 human S807 447980 PGGNIyIsPLksPyk Rb_C X 9308; 8974; 4277; 40283; 8957; 8516; 11917; 99274; 41359; 75864; 72443 +CDK1 CDK1 P06493 human SCML2 10389 Q9UQR0 SCML2 human S590 3216624 sPLVGDIsPKssPHE X X +CDK1 CDK1 P06493 human USP24 23358 Q9UPU5 USP24 human S2047 451983 QRVSDQNsPVLPKKS X +CDK1 CDK1 P06493 human WAC 51322 Q9BTA9 WAC human T457 469444 YVsPRIstPQtNTVP X X +CDK1 CDK1 P06493 human CCNE1 898 P24864 CCNE1 human S399 454414 GLLtPPQsGKKQSSG X +CDK1 CDK1 P06493 human NUP98 iso2 4928 P52948-2 NUP98 human S595 470432 LNNsNLFsPVNRDSE X +CDK1 CDK1 P06493 human ULK1 22241 O70405 Ulk1 mouse T635 4699275 PsFDFPKtPssQNLL X +CDK1 CDK1 P06493 human MST2 6788 Q13188 STK3 human S385 4274113 tMKRNAtsPQVQRPs X X +CDK1 CDK1 P06493 human USP24 23358 Q9UPU5 USP24 human S1616 22547101 NsHsPAGsAAIsQQD X +CDK1 CDK1 P06493 human DRP1 114114 O35303 Dnm1l rat S635 454690 PIPIMPAsPQKGHAV X 3455; 4494; 63940 +CDK1 CDK1 P06493 human MEF2C 4208 Q06413 MEF2C human S396 456980 NIkSEPVsPPRDRTT X +CDK1 CDK1 P06493 human CDC14A 8556 Q9UNH5 CDC14A human S549 1216243800 SNGGNLNsPPGPHSA X X +CDK1 CDK1 P06493 human JunB 24517 P24898 Junb rat S186 1814003 YTNLSSYsPASAPSG Jun X X +CDK1 CDK1 P06493 human NCL 4691 P19338 NCL human T707 21697921 HKPQGKKtKFE____ X X +CDK1 CDK1 P06493 human MCM7 4176 P33993 MCM7 human S121 3189844 RDPGMVRsPQNQYPA MCM_N X X +CDK1 CDK1 P06493 human CREB 1385 P16220 CREB1 human S256 3181028 APGVVMAssPALPTQ X X +CDK1 CDK1 P06493 human SAPS2 9701 O75170 PPP6R2 human S771 4764365 ESGPRCSsPVDTECS X +CDK1 CDK1 P06493 human lamin A/C 16905 P48678 Lmna mouse S390 452605 EEERLRLsPsPtsQR X +CDK1 CDK1 P06493 human TNRC15 26058 Q6Y7W6 GIGYF2 human S30 483131 sItsPPLsPALPkYk X +CDK1 CDK1 P06493 human GRASP65 56082 O35254 Gorasp1 rat S277 455582 EQLPGPGsPGHGTAD X +CDK1 CDK1 P06493 human CDC27 996 P30260 CDC27 human T446 455863 EGkIStItPQIQAFN X X +CDK1 CDK1 P06493 human TOP1 7150 P11387 TOP1 human S112 2721302 EKENGFssPPQIkDE X +CDK1 CDK1 P06493 human FLNA 2316 P21333 FLNA human S1459 452266 kCsGPGLsPGMVRAN Filamin X +CDK1 CDK1 P06493 human CDC25C 398119 P30309 cdc25c-b frog S285 448417 NRSRLYRsPsMPEKL M-inducer_phosp X +CDK1 CDK1 P06493 human kindlin-2 10979 Q96AC1 FERMT2 human S180 3208611 PGsGsIyssPGLysk X X +CDK1 CDK1 P06493 human MAP7 293016 NP_001099740 Map7 rat S231 460314 sSATLLNsPDRARRL X +CDK1 CDK1 P06493 human FOXM1 2305 Q08050 FOXM1 human T620 3194573 SkSVLPRtPEsWRLt X +CDK1 CDK1 P06493 human AML1 iso8 861 Q01196-8 RUNX1 human S293 454400 QYLGSIAsPSVHPAt X +CDK1 CDK1 P06493 human PHLPP 23239 O60346 PHLPP1 human S323 31884076 AsPAPsDssPGEPFV X X +CDK1 CDK1 P06493 human Tau iso8 4137 P10636-8 MAPT human T205 447933 ssPGsPGtPGsRsRt X 25377; 43964; 53001; 49561; 20060; 33032; 30505; 20739; 98160 +CDK1 CDK1 P06493 human Borealin 55143 Q53HL2 CDCA8 human S219 460351 YNIsGNGsPLADskE Borealin X +CDK1 CDK1 P06493 human ERK1 iso3 5595 P27361-3 MAPK3 human S343 50703500 PTDEVGQsPAAVGLG X X +CDK1 CDK1 P06493 human MAP4 4134 P27816 MAP4 human T901 2130500 MPsRPsttPFIDKKP X +CDK1 CDK1 P06493 human TOP2A 7153 P11388 TOP2A human S1393 452242 GsVPLsssPPAtHFP X +CDK1 CDK1 P06493 human NPM1 4869 P06748 NPM1 human T237 449560 kQEKtPKtPkGPssV X X +CDK1 CDK1 P06493 human CDC25C 398119 P30309 cdc25c-b frog T138 449911 LPRLLCStPSFKKTS M-inducer_phosp X +CDK1 CDK1 P06493 human APC1 64682 Q9H1A4 ANAPC1 human T701 455835 kkARPsEtGsDDDWE Apc1_MidN X +CDK1 CDK1 P06493 human RANGAP1 19387 P46061 Rangap1 mouse S444 449222 stFLsFPsPEKLLRL RanGAP1_C X +CDK1 CDK1 P06493 human PPP1CA 24668 P62138 Ppp1ca rat T320 448686 NPGGRPItPPRNSAK X +CDK1 CDK1 P06493 human SQSTM1 8878 Q13501 SQSTM1 human S272 454787 RsRLtPVsPEssstE X X 13121 +CDK1 CDK1 P06493 human PHLPP 23239 O60346 PHLPP1 human T451 3952371 APGGLQstPGRSGVT X X +CDK1 CDK1 P06493 human KIBRA 23286 Q8IX03 WWC1 human S931 3205620 IIRsKtFsPGPQSQy X X +CDK1 CDK1 P06493 human APC1 64682 Q9H1A4 ANAPC1 human T530 455829 NtMPRPstPLDGVst X +CDK1 CDK1 P06493 human HMGA1 iso2 3159 P17096-2 HMGA1 human T42 451515 kEPsEVPtPkrPrGr X +CDK1 CDK1 P06493 human BORA 79866 Q6PGQ7 BORA human S112 27444813 TkDVIVPsPWTDHEG BORA_N X X +CDK1 CDK1 P06493 human KIF11 3832 P52732 KIF11 human T926 448410 LDIPtGttPQRksyL Microtub_bind X +CDK1 CDK1 P06493 human lamin A/C 4000 P02545 LMNA human S392 452606 ErLRLsPsPtsQRsR X +CDK1 CDK1 P06493 human HJURP 55355 Q8NCD3 HJURP human S412 453537 RTLkWLIsPVkIVSR HJURP_C X +CDK1 CDK1 P06493 human 53BP1 7158 Q12888 TP53BP1 human T1609 486510 LGPyEAVtPLtkAAD X +CDK1 CDK1 P06493 human HMGA2 15364 P52927 Hmga2 mouse S44 4033091 QEPTCEPsPKRPRGR X +CDK1 CDK1 P06493 human CDT1 81620 Q9H211 CDT1 human T406 21440503 LPAtPPAtPPAAsPs X X +CDK1 CDK1 P06493 human PPP1R13L 10848 Q8WUF5 PPP1R13L human S84 5197296 EPFGsrGsPRkAAtD X +CDK1 CDK1 P06493 human Rb 5925 P06400 RB1 human S811 448717 IyIsPLksPykIsEG Rb_C X 9308; 8974; 4277; 40283; 8957; 8516; 11917; 41359; 75864; 63276 +CDK1 CDK1 P06493 human EZH2 2146 Q15910 EZH2 human T345 4957354 LtAERIKtPPkRPGG X X 45153 +CDK1 CDK1 P06493 human NCAPG 64151 Q9BPX3 NCAPG human T332 5014904 LIPVETLtPEIALYW X +CDK1 CDK1 P06493 human p300 2033 Q09472 EP300 human S2039 31828207 GLGQVGIsPLKPGTV Creb_binding X X +CDK1 CDK1 P06493 human hnRNP K 3190 P61978 HNRNPK human S216 450148 ILDLIsEsPIkGRAQ X +CDK1 CDK1 P06493 human LATS1 9113 O95835 LATS1 human S613 457596 EKKQITtsPItVRKN X X +CDK1 CDK1 P06493 human Tau iso8 4137 P10636-8 MAPT human S235 449080 VVRtPPKsPssAKsR X 20473 +CDK1 CDK1 P06493 human K8 3856 P05787 KRT8 human S432 448540 sAyGGLtsPGLsysL X X +CDK1 CDK1 P06493 human ADD1 118 P35611 ADD1 human S355 456832 kYKAKsRsPGsPVGE X +CDK1 CDK1 P06493 human ZC3H11A 9877 O75152 ZC3H11A human T321 3175981 PETNIDKtPKKAQVs X +CDK1 CDK1 P06493 human KIF20A 10112 O95235 KIF20A human S21 4921068 sDDDVVVsPMFESTA X +CDK1 CDK1 P06493 human NDUFB6 4712 O95139 NDUFB6 human S55 33402203 NkFLENksPWRKMVH NDUF_B6 X X +CDK1 CDK1 P06493 human p300 2033 Q09472 EP300 human S1038 10941006 STSATQssPAPGQsk X X +CDK1 CDK1 P06493 human TOP2A 7153 P11388 TOP2A human S1213 452237 QMAEVLPsPRGQRVI X +CDK1 CDK1 P06493 human CLASP2 23122 O75122 CLASP2 human S541 24976300 REssRDTsPVRSFQP X +CDK1 CDK1 P06493 human YAP1 10413 P46937 YAP1 human S138 485036 sLQLGAVsPGtLtPt X +CDK1 CDK1 P06493 human Jun 24516 P17325 Jun rat S246 450451 PGETPPLsPIDMESQ X 2994 +CDK1 CDK1 P06493 human SIRT1 23411 Q96EB6 SIRT1 human S540 4770118 HVsEDsssPERtsPP X +CDK1 CDK1 P06493 human SIRT2 22933 Q8IXJ6 SIRT2 human S368 482809 PNPsTsAsPKKsPPP X X +CDK1 CDK1 P06493 human NME2 83782 P19804 Nme2 rat S120 4714197 GRNIIHGsDSVEsAE NDK X +CDK1 CDK1 P06493 human NANOG 79923 Q9H9S0 NANOG human S71 31960307 DsPDsStsPKGKQPt X +CDK1 CDK1 P06493 human SLX4 84464 Q8IY92 SLX4 human T1561 1880104208 LPPKVPItPMPQYSI X +CDK1 CDK1 P06493 human JunB 24517 P24898 Junb rat T150 1814004 LHKMNHVtPPNVSLG Jun X X +CDK1 CDK1 P06493 human NHERF 9368 O14745 NHERF1 human S280 470168 LAEAALEsPRPALVR EBP50_C X +CDK1 CDK1 P06493 human gephyrin 64845 Q03555 Gphn rat S283 2020113 LSttPsEsPRAQAts X +CDK1 CDK1 P06493 human ULK1 22241 O70405 Ulk1 mouse S983 1869357209 TAERLILsHAVQMVQ DUF3543 X +CDK1 CDK1 P06493 human EEF1D iso2 1936 P29692-2 EEF1D human S499 455672 APQTQHVsPMRQVEP X +CDK1 CDK1 P06493 human BORA 79866 Q6PGQ7 BORA human S137 9320596 CTNINsDsPVGKkLT BORA_N X X +CDK1 CDK1 P06493 human CDCA5 113130 Q96FF9 CDCA5 human S79 470691 AVQsPRRsPRIsFFL X X +CDK1 CDK1 P06493 human TREX1 22040 Q91XB0 Trex1 mouse S261 2579810 PLATANGsPSNGRSR X +CDK1 CDK1 P06493 human p53 7157 P04637 TP53 human S315 447530 LPNNtsssPQPkkkP X X 2528 +CDK1 CDK1 P06493 human MAP4 4134 P27816 MAP4 human T892 2130502 VPSRVKAtPMPsRPs X +CDK1 CDK1 P06493 human CDC27 996 P30260 CDC27 human S426 455859 TQPNINDsLEItkLD X +CDK1 CDK1 P06493 human WAC 51322 Q9BTA9 WAC human T244 36128588 AETHSSStPVQHPIK X X +CDK1 CDK1 P06493 human NEK9 91754 Q8TD19 NEK9 human T210 451116 SEYsMAEtLVGtPYY Pkinase X +CDK1 CDK1 P06493 human MAP4 4134 P27816 MAP4 human S787 448480 KAPEkRAsPsKPAsA X X +CDK1 CDK1 P06493 human APLP2 334 Q06481 APLP2 human T736 451599 VEVDPMLtPEERHLN APP_amyloid X +CDK1 CDK1 P06493 human cGAS 214763 Q8C6L5 Cgas mouse S291 36128853 VEKEKPGsPAVTLLI Mab-21 X +CDK1 CDK1 P06493 human MCM3 17215 P25206 Mcm3 mouse S112 2840507 SFGSKHVsPRTLTSC MCM_OB X 12686 +CDK1 CDK1 P06493 human palladin 23022 Q8WX93 PALLD human S641 3207888 PtPAVLLsPTKEPPP X +CDK1 CDK1 P06493 human H1E 3008 P10412 H1-4 human T18 467971 APAPAEktPVkKKAR X +CDK1 CDK1 P06493 human MAN1A1 4121 P33908 MAN1A1 human S12 15411997 GLLPLFSsPAGGVLG X X +CDK1 CDK1 P06493 human Vimentin 7431 P08670 VIM human S56 451514 srsLyAssPGGVyAt Filament_head X 3877; 7391 +CDK1 CDK1 P06493 human AR 367 P10275 AR human S516 452166 VSRVPYPsPTCVkSE X +CDK1 CDK1 P06493 human Akt1 207 P31749 AKT1 human T308 447856 kDGAtMKtFCGtPEy Pkinase X 5106; 2965; 9275; 4056; 5056; 13842; 13038; 43506; 48646; 86758; 80722; 77440; 80556 +CDK1 CDK1 P06493 human EFHD2 298609 Q4FZY0 Efhd2 rat S73 478224 QGIGEPQsPSRRVFN X +CDK1 CDK1 P06493 human NANOG 79923 Q9H9S0 NANOG human S65 31960311 MDLLIQDsPDsStsP X +CDK1 CDK1 P06493 human FLNA 2316 P21333 FLNA human S1436 478363 GGHQVPGsPFKVPVH Filamin X +CDK1 CDK1 P06493 human AKAP12 9590 Q02952 AKAP12 human T767 3801512 EsFkRLVtPRKksKS WSK X X +CDK1 CDK1 P06493 human Chk1 12649 O35280 Chek1 mouse S301 465528 IHsNLDFsPVNNGSs X +PRKG1 PKG1 iso2 Q13976-2 human CRIP2 338401 P36201 Crip2 rat S104 3141905 RTEERKTsGPPKGPS X +PRKG1 PKG1 iso2 Q13976-2 human HSP27 3315 P04792 HSPB1 human T143 471871 RCFtRkytLPPGVDP HSP20 X +PRKG1 PKG1 iso2 Q13976-2 human HSP27 3315 P04792 HSPB1 human S15 448401 FsLLrGPsWDPFrDW X 2404 +PRKG1 PKG1 iso2 Q13976-2 human PKG1 iso2 5592 Q13976-2 PRKG1 human S65 2864204 TQQAQKQsASTLQGE X +PRKG1 PKG1 iso2 Q13976-2 human HSP27 3315 P04792 HSPB1 human S82 448403 RALsRQLssGVsEIr X 2406; 2401; 9709; 11892; 64293 +PRKG1 PKG1 iso2 Q13976-2 human HSP27 3315 P04792 HSPB1 human S78 448402 PAysRALsRQLssGV X 2405 +PRKG1 PKG1 iso2 Q13976-2 human PKG1 iso2 5592 Q13976-2 PRKG1 human S81 452147 RtKRQAIsAEPTAFD X +PRKG1 PKG1 iso2 Q13976-2 human PAK1 5058 Q13153 PAK1 human S21 448174 APPMRNtsTMIGAGs X +PRKG1 PKG1 iso2 Q13976-2 human Lasp-1 3927 Q14847 LASP1 human S146 448836 MEPERRDsQDGssyR X X +Tnk2 Ack O54967 mouse Akt1 11651 P31750 Akt1 mouse Y176 14515900 EKATGRYyAMKILKK Pkinase X X +Pim1 Pim1 P06803 mouse BAD 12015 Q61337 Bad mouse S112 447860 ETRsRHssyPAGtEE Bcl-2_BAD X X 9291; 5284; 9296; 5193; 11865; 94223 +Pim1 Pim1 P06803 mouse NOTCH3 18131 Q61982 Notch3 mouse S1673 11179168 ARRKREHsTLWFPEG X X +Pim1 Pim1 P06803 mouse BAD 12015 Q61337 Bad mouse S136 447862 PFRGRsRsAPPNLWA Bcl-2_BAD X 9295; 5286; 4366 +KSR1 KSR Q8IVT5 human RAF1 5894 P04049 RAF1 human T269 447747 NVHMVsttLPVDSRM X X +STK33 STK33 Q9BYT3 human STK33 65975 Q9BYT3 STK33 human T382 25755119 LLDNQWLtGNkLSSV X X +SIK3 QSK Q9Y2K2 human TORC3 70461 Q91X84 Crtc3 mouse S162 7101661 SALNRTNsDSALHTS TORC_M X +SIK3 QSK Q9Y2K2 human TORC3 70461 Q91X84 Crtc3 mouse S370 1210886 SLRLFsLsNPsLSTT X +SIK3 QSK Q9Y2K2 human TORC3 70461 Q91X84 Crtc3 mouse S62 3203139 LtQyHGGsLPNVSQL TORC_N X +SIK3 QSK Q9Y2K2 human HDAC4 208727 Q6NZM9 Hdac4 mouse S245 448488 FPLRKTAsEPNLKLR X 3443 +SIK3 QSK Q9Y2K2 human TORC3 70461 Q91X84 Crtc3 mouse S329 468980 SGLQSsRsNPsIQAT X +PAK4 PAK4 O96013 human NRF2 4780 Q16236 NFE2L2 human T369 1876350200 ESSSYGDtLLGLsDs X X +PAK4 PAK4 O96013 human CTNNB1 1499 P35222 CTNNB1 human S675 457120 QDykKRLsVELtsSL X X 9567; 4176; 68076 +PAK4 PAK4 O96013 human Snail2 6591 O43623 SNAI2 human S254 63243402 sKTFsRMsLLHKHEE zf-C2H2 X X +PAK4 PAK4 O96013 human N-WASP 8976 O00401 WASL human S484 3149548 KRSKAIHssDEDEDE X +PAK4 PAK4 O96013 human PXN iso2 5829 P49023-2 PXN human S272 465466 ELDELMAsLSDFKFM X X +PAK4 PAK4 O96013 human MZF-1 7593 P28698 MZF1 human S27 50784428 VMVkLEDsEEEGEAA X +PAK4 PAK4 O96013 human LIMK2 3985 P53671 LIMK2 human T505 448683 NDRKKRYtVVGNPYW PK_Tyr_Ser-Thr X 3841 +PAK4 PAK4 O96013 human ARHGEF2 iso2 9181 Q92974-2 ARHGEF2 human S885 451365 PVDPRRRsLPAGDAL X 14143 +PAK4 PAK4 O96013 human TORC1 684527 Q157S1 Crtc1 rat S215 60885604 KAGSRPKsCEVPGIN TORC_M X +PAK4 PAK4 O96013 human CTNNB1 12387 Q02248 Ctnnb1 mouse S675 457120 QDykKRLsVELtSsL X X 9567; 4176; 68076 +PAK4 PAK4 O96013 human STMN2 11075 Q93045 STMN2 human S50 455606 KQINKRAsGQAFELI Stathmin X X +PAK4 PAK4 O96013 human ICAP1 9270 O14713 ITGB1BP1 human S10 1872961000 RKGKKRHssSsSQSS ICAP-1_inte_bdg X X +PAK4 PAK4 O96013 human Snail2 6591 O43623 SNAI2 human S158 1162843400 CDAQSRKsFSCKYCD X X +PAK4 PAK4 O96013 human PAK4 10298 O96013 PAK4 human S474 448023 kEVPRRksLVGtPyW Pkinase X X 3241 +PAK4 PAK4 O96013 human LIMK1 16885 P53668 Limk1 mouse T508 447808 PDRKKRYtVVGNPYW PK_Tyr_Ser-Thr X 3841 +PAK4 PAK4 O96013 human AML1 861 Q01196 RUNX1 human T207 34551130 ELEQLRrtAMrVsPH X +PAK4 PAK4 O96013 human ITGB5 3693 P18084 ITGB5 human S759 14694704 REFAkFQsERsRARy Integrin_b_cyt X X +PAK4 PAK4 O96013 human N-WASP 8976 O00401 WASL human S485 3149547 RSKAIHssDEDEDED X +PAK4 PAK4 O96013 human ITGB5 3693 P18084 ITGB5 human S762 14694703 AkFQsERsRARyEMA Integrin_b_cyt X X +PAK4 PAK4 O96013 human fumarase 2271 P07954 FH human S46 36132325 PNAARMAsQNSFRIE X X +PAK4 PAK4 O96013 human TH 7054 P07101 TH human S71 448545 RFIGRRQsLIEDARK TOH_N X X 2791 +PAK4 PAK4 O96013 human Akt1 11651 P31750 Akt1 mouse S473 447855 RPHFPQFsysAsGtA Pkinase_C X X 9271; 3787; 4060; 4051; 5102; 4058; 2336; 2337; 4075; 4070; 5012; 4071; 92982; 5315; 9563; 9018; 12694; 52240; 11962; 15116; 88106; 26580; 68035; 31957; 23430; 20235 +PAK4 PAK4 O96013 human RAN 5901 P62826 RAN human S135 469112 DRkVKAksIVFHRkk Ras X X +PAK4 PAK4 O96013 human p53 7157 P04637 TP53 human S215 454242 DrNtFrHsVVVPyEP P53 X X +PAK4 PAK4 O96013 human LIMK1 3984 P53667 LIMK1 human T508 447808 PDRKKRYtVVGNPYW PK_Tyr_Ser-Thr X X 3841 +PAK4 PAK4 O96013 human ER-alpha 2099 P03372 ESR1 human S305 448805 IkRSkkNsLALSLtA X +Mark2 MARK2 O08679 rat Tau iso8 4137 P10636-8 MAPT human S262 447930 NVKskIGstENLkHQ Tubulin-binding X X +Mark2 MARK2 O08679 rat Tau iso8 4137 P10636-8 MAPT human S324 449328 kVtskCGsLGNIHHk Tubulin-binding X +Mark2 MARK2 O08679 rat Tau iso8 4137 P10636-8 MAPT human S293 449327 NVQskCGsKDNIkHV Tubulin-binding X +Mark2 MARK2 O08679 rat Tau iso8 4137 P10636-8 MAPT human S356 449104 rVQskIGsLDNItHV Tubulin-binding X +Mark2 MARK2 O08679 rat Tau 29477 P19332 Mapt rat S573 447930 NVRSKIGsTENLKHQ Tubulin-binding X +MYLK2 skMLCK Q9H1R3 human MEF2C 4208 Q06413 MEF2C human T80 19083402 NEPHESRtNsDIVEt X +Ntrk2 TrkB Q63604 rat TrkB 25054 Q63604 Ntrk2 rat Y706 448812 DVyStDyyRVGGHTM PK_Tyr_Ser-Thr X X 4621 +Ntrk2 TrkB Q63604 rat PLCG1 25738 P10686 Plcg1 rat Y1253 448576 EGsFEARyQQPFEDF X +Ntrk2 TrkB Q63604 rat TrkB 25054 Q63604 Ntrk2 rat Y701 451661 FGMSRDVyStDyyRV PK_Tyr_Ser-Thr X X +Ntrk2 TrkB Q63604 rat TrkB 25054 Q63604 Ntrk2 rat Y816 451754 LAkAsPVyLDILG__ X 4168 +Ntrk2 TrkB Q63604 rat TrkB 25054 Q63604 Ntrk2 rat Y705 448811 RDVyStDyyRVGGHT PK_Tyr_Ser-Thr X X 4621 +Ntrk2 TrkB Q63604 rat PLCG1 25738 P10686 Plcg1 rat Y783 447667 EGRNPGFyVEANPMP X 2821; 14461; 14008; 25678; 88717 +Ntrk2 TrkB Q63604 rat NCAM1 17967 P13595 Ncam1 mouse Y734 454070 VVMDITCyFLNKCGL X +Ntrk2 TrkB Q63604 rat TrkB 25054 Q63604 Ntrk2 rat Y515 448813 PVIENPQyFGITNSQ X X 4619 +Ntrk2 TrkB Q63604 rat NCAM1 24586 P13596 Ncam1 rat Y744 454070 VVMDITCyFLNKCGL X +Hipk1 HIPK1 O88904 mouse DAXX 13163 O35613 Daxx mouse S669 7249306 TsVQPMPsPPLAsVA X +Mapkapk5 MAPKAPK5 O54992 mouse WNK4 65266 Q96J92 WNK4 human S575 53332700 PFLFRHAsYSSTTSD X +Mapkapk5 MAPKAPK5 O54992 mouse RHEB 6009 Q15382 RHEB human S130 18157800 LHMERVIsYEEGkAL Ras X +Mapkapk5 MAPKAPK5 O54992 mouse PLA2G4A 18783 P47713 Pla2g4a mouse S726 447599 RQNPsRCsVsLsNVE X +Abl1 Abl P00520 mouse RAPH1 65059 Q70E73 RAPH1 human Y426 465028 LLRAsGIyYVPKGKA PH X +Abl1 Abl P00520 mouse RAPH1 77300 G5E867 Raph1 mouse Y479 465028 LLRAsGIyYVPKGKA PH X +Abl1 Abl P00520 mouse hnRNP P2 233908 P56959 Fus mouse Y518 50318713 QDRRERPy_______ X +Abl1 Abl P00520 mouse BMPR1A 12166 P36895 Bmpr1a mouse Y458 25655002 EEyQLPyyNMVPSDP PK_Tyr_Ser-Thr X +Abl1 Abl P00520 mouse PLSCR1 5359 O15162 PLSCR1 human Y69 2915403 PVPNQPVyNQPVyNQ X +Abl1 Abl P00520 mouse RAPH1 65059 Q70E73 RAPH1 human Y456 26348502 NVYYGQDyRNKYKAP PH X +Abl1 Abl P00520 mouse APP iso4 351 P05067-4 APP human Y682 448202 sKMQQNGyENPTyKF APP_amyloid X +Abl1 Abl P00520 mouse ZAP70 22637 P43404 Zap70 mouse Y318 447587 TSVyESPySDPEELK X 2701; 2717; 14791; 73382; 82975; 31754 +Abl1 Abl P00520 mouse CDV-3 321022 Q4VAA2 Cdv3 mouse Y120 450290 FEQREVDySGLRVQA CDV3 X +Abl1 Abl P00520 mouse BMPR1A 12166 P36895 Bmpr1a mouse Y453 3712679 TGGIVEEyQLPyyNM PK_Tyr_Ser-Thr X +Abl1 Abl P00520 mouse RAPH1 65059 Q70E73 RAPH1 human Y1226 458696 GGSHIsGyAtLRRGP X +Abl1 Abl P00520 mouse p27Kip1 1027 P46527 CDKN1B human Y88 456818 kGsLPEFyyRPPRPP X X +Abl1 Abl P00520 mouse Abl 11350 P00520 Abl1 mouse Y393 450298 RLMTGDTytAHAGAK PK_Tyr_Ser-Thr X 2865 +Abl1 Abl P00520 mouse Fe65 11785 Q9QXJ1 Apbb1 mouse Y547 451143 VQKFQVYyLGNVPVA PID X X +Abl1 Abl P00520 mouse CBL 867 P22681 CBL human Y774 448531 sENEDDGyDVPKPPV X 3555 +Abl1 Abl P00520 mouse Mena iso3 13800 Q03173-3 Enah mouse Y296 449088 PLPSGPAyASALPPP X +Abl1 Abl P00520 mouse BMPR1A 12166 P36895 Bmpr1a mouse Y457 25655000 VEEyQLPyyNMVPSD PK_Tyr_Ser-Thr X +Abl1 Abl P00520 mouse PARP1 iso3 11545 Q3TF18 Parp1 mouse Y829 1869121001 HATTHNAyDLEVIDI PARP X +Abl1 Abl P00520 mouse Abl 11350 P00520 Abl1 mouse Y226 450303 KRNKPTIyGVSPNyD X 2868; 2861 +Abl1 Abl P00520 mouse BMPR1A 12166 P36895 Bmpr1a mouse Y467 25655001 MVPSDPSyEDMREVV PK_Tyr_Ser-Thr X +Abl1 Abl P00520 mouse PKCD 18753 P28867 Prkcd mouse Y311 447573 TTEsVGIyQGFEKKP X 2055 +Abl1 Abl P00520 mouse CBL 867 P22681 CBL human Y700 448529 EGEEDtEyMtPssRP X 8869 +Abl1 Abl P00520 mouse DOK1 13448 P97465 Dok1 mouse Y361 448367 DsKEDPIyDEPEGLA X X +Abl1 Abl P00520 mouse RAPH1 iso4 77300 F2Z3U3 Raph1 mouse Y1242 458696 GGSHISGyATLRRGP X +Abl1 Abl P00520 mouse PLSCR1 5359 O15162 PLSCR1 human Y74 464050 PVyNQPVyNQPVGAA X +Abl1 Abl P00520 mouse Cortactin 13043 Q60598 Cttn mouse Y466 447703 TyTSEPVyETTEAPG X +Abl1 Abl P00520 mouse DGCR8 54487 Q8WYQ5 DGCR8 human Y267 479394 KRRTEEKyGGDsDHP X +Abl1 Abl P00520 mouse CDK5 12568 P49615 Cdk5 mouse Y15 448022 EkIGEGtyGtVFKAK Pkinase X 94254; 19051 +Abl1 Abl P00520 mouse Doublecortin 13193 O88809 Dcx mouse Y125 1833062501 ELEEGESyVCSSDNF DCX X +Abl1 Abl P00520 mouse UBE3A iso2 7337 Q05086-2 UBE3A human Y636 50838700 GDSHPVLyQSLKDLL HECT X X +Abl1 Abl P00520 mouse DGKA 397097 P20192 DGKA pig Y217 22874703 KRFPRPVyCNLCESS C1_1 X X +Abl1 Abl P00520 mouse RAPH1 65059 Q70E73 RAPH1 human Y513 477344 GKQLyMNyQEALKRT X +Abl1 Abl P00520 mouse WAVE2 242687 Q8BH43 Wasf2 mouse Y150 455197 GKEALKFyTNPSyFF X +Erbb2 HER2 P70424 mouse YAP1 22601 P46938 Yap1 mouse S112 448847 PQHVRAHssPAsLQL X 4911; 13008; 92367; 57706 +Erbb2 HER2 P70424 mouse YAP1 22601 P46938 Yap1 mouse S94 452305 KsHsRQAstDAGtAG X 46931; 53749 +Csnk1a1 CK1A P97633 rat AQP2 359 P41181 AQP2 human S256 449854 REVRRRQsVELHsPQ X +Csnk1a1 CK1A P97633 rat CTNNB1 1499 P35222 CTNNB1 human S45 447488 GATtTAPsLsGkGNP X 9565; 9564; 24710; 70034; 19807; 96727; 77605 +Csnk1a1 CK1A P97633 rat NFAT4 4775 Q12968 NFATC3 human S180 3081705 RSWFsDAssCEsLsH X +Csnk1a1 CK1A P97633 rat GRP94 7184 P14625 HSP90B1 human S347 3082300 kPIWQRPskEVEEDE HSP90 X +Csnk1a1 CK1A P97633 rat galectin-3 3958 P17931 LGALS3 human S6 450131 __MADNFsLHDALsG X +Csnk1a1 CK1A P97633 rat NFAT4 4775 Q12968 NFATC3 human S177 3081701 ISsRSWFsDAssCEs X +Csnk1a1 CK1A P97633 rat FADD 8772 Q13158 FADD human S194 447653 QNRsGAMsPMsWNsD X 2781 +Csnk1a1 CK1A P97633 rat NFAT4 4775 Q12968 NFATC3 human S165 448858 RESSLsPsPASSISs X +Csnk1a1 CK1A P97633 rat PRH 5555 P02810 PRH2 human S38 451071 VIsDGGDsEQFIDEE Pro-rich X +Csnk1a1 CK1A P97633 rat PRH 5555 P02810 PRH2 human S24 451070 QDLDEDVsQEDVPLV Pro-rich X +Csnk1a1 CK1A P97633 rat CSN2 281099 P02666 CSN2 cow S50 467292 KKIEKFQsEEQQQTE X +Csnk1a1 CK1A P97633 rat NFAT4 4775 Q12968 NFATC3 human S186 3081704 AssCEsLsHIYDDVD X +Csnk1a1 CK1A P97633 rat EIF4B 300253 Q5RKG9 Eif4b rat S504 452271 ssDtEQPsPTSGGGK X +Csnk1a1 CK1A P97633 rat NFAT4 4775 Q12968 NFATC3 human S181 3081702 SWFsDAssCEsLsHI X +Csnk1a1 CK1A P97633 rat NFAT4 4775 Q12968 NFATC3 human S184 3081703 sDAssCEsLsHIYDD X +CHEK2 Chk2 O96017 human MBP 618684 P02687 MBP cow T64 487423 DGHHAARtTHYGSLP Myelin_MBP X +CHEK2 Chk2 O96017 human SIAH2 6478 O43255 SIAH2 human S68 5393502 GGGAGPVsPQHHELT X +CHEK2 Chk2 O96017 human BRCA1 12189 P48754 Brca1 mouse S971 448526 QSVSPIRsSIKTDNR X +CHEK2 Chk2 O96017 human p53 7157 P04637 TP53 human S37 447532 NVLsPLPsQAMDDLM TAD2 X 9289 +CHEK2 Chk2 O96017 human Chk2 11200 O96017 CHEK2 human S33 447549 tQsQGSSsQsQGIss X 2665 +CHEK2 Chk2 O96017 human Chk2 11200 O96017 CHEK2 human S435 2811404 SEHRtQVsLkDQITS Pkinase X +CHEK2 Chk2 O96017 human TTK 7272 P33981 TTK human T288 6370307 sPDCDVktDDsVVPC X X +CHEK2 Chk2 O96017 human AATF 26574 Q9NY61 AATF human S510 3753302 KKVDRKAsKGRKLRF TRAUB X +CHEK2 Chk2 O96017 human SIAH2 6478 O43255 SIAH2 human T119 26371004 PTCRGALtPSIRNLA X +CHEK2 Chk2 O96017 human AurB 9212 Q96GD4 AURKB human S331 22259700 HPWVRANsRRVLPPS X +CHEK2 Chk2 O96017 human IRTKS 55971 Q9UHR4 BAIAP2L1 human S331 2509171 PSLQRsVsVAtGLNM X +CHEK2 Chk2 O96017 human LATS2 26524 Q9NRM7 LATS2 human S446 17600401 HILHPVKsVRVLRPE X +CHEK2 Chk2 O96017 human p53 7157 P04637 TP53 human T18 447541 EPPLsQEtFsDLWkL P53_TAD X 2529 +CHEK2 Chk2 O96017 human HuR 1994 Q15717 ELAVL1 human T118 474554 sGLPRTMtQkDVEDM RRM_1 X X +CHEK2 Chk2 O96017 human PML iso3 5371 P29590-3 PML human S117 455494 ESLQRRLsVYRQIVD X X +CHEK2 Chk2 O96017 human LATS2 26524 Q9NRM7 LATS2 human S408 17600400 PVPSRTNsFNSHQPR X +CHEK2 Chk2 O96017 human beclin 1 8678 Q14457 BECN1 human S93 5473540 ARMMstEsANsFTLI X X 14717 +CHEK2 Chk2 O96017 human MBP 618684 P02687 MBP cow T33 451756 FLPRHRDtGILDSLG Myelin_MBP X +CHEK2 Chk2 O96017 human AATF 26574 Q9NY61 AATF human S143 3753301 SKKSRSHsAktPGFs X +CHEK2 Chk2 O96017 human E2F1 1869 Q01094 E2F1 human S364 449403 PLLSRMGsLRAPVDE X X +CHEK2 Chk2 O96017 human Tau iso8 4137 P10636-8 MAPT human S262 447930 NVKskIGstENLkHQ Tubulin-binding X X +CHEK2 Chk2 O96017 human H1C 3006 P16403 H1-2 human T92 487416 ksLVskGtLVQTkGt Linker_histone X +CHEK2 Chk2 O96017 human BRCA1 672 P38398 BRCA1 human S988 448526 PPLFPIksFVKTKCK X X +CHEK2 Chk2 O96017 human VHL 7428 P40337 VHL human S111 22516600 GtGRRIHsyRGHLWL VHL X X +CHEK2 Chk2 O96017 human H1C 3006 P16403 H1-2 human S55 487418 VAAskErsGVsLAAL Linker_histone X +CHEK2 Chk2 O96017 human LATS2 26524 Q9NRM7 LATS2 human S380 3213669 ATLARRDsLQKPGLE X +CHEK2 Chk2 O96017 human XRCC1 7515 P18887 XRCC1 human S210 5014906 AsDPAGPsyAAATLQ X +CHEK2 Chk2 O96017 human Chk2 11200 O96017 CHEK2 human S19 447546 sHGsSACsQPHGsVt X 2666 +CHEK2 Chk2 O96017 human perilipin 3 10226 O60664 PLIN3 human Y251 1873650102 ErLRQHAyEHSLGkL Perilipin X X +CHEK2 Chk2 O96017 human H1C 3006 P16403 H1-2 human T167 487415 kPAAAtVtkkVAKsP X +CHEK2 Chk2 O96017 human MBP 618684 P02687 MBP cow S150 487420 HDAQGtLsKIFKLGG Myelin_MBP X +CHEK2 Chk2 O96017 human XRCC1 7515 P18887 XRCC1 human T284 5014905 APtRtPAtAPVPARA X X +CHEK2 Chk2 O96017 human CDC25C 995 P30307 CDC25C human S216 448418 sGLyRsPsMPENLNR M-inducer_phosp X 9528; 4901; 30790 +CHEK2 Chk2 O96017 human perilipin 2 123 Q99541 PLIN2 human Y232 1873650100 TkLHSRAyQQALsRV Perilipin X X +CHEK2 Chk2 O96017 human Rb 5925 P06400 RB1 human S612 447977 MyLsPVRsPKKKGsT X X +CHEK2 Chk2 O96017 human CDC25A 993 P30304 CDC25A human S279 449129 VLKRPErsQEEsPPG M-inducer_phosp X +CHEK2 Chk2 O96017 human MBP 618684 P02687 MBP cow S17 487422 sKYLASAstMDHARH Myelin_MBP X +CHEK2 Chk2 O96017 human REV3 5980 O60673 REV3L human S1075 3363400 ENIKRTLsFRKKRSH DUF4683 X +CHEK2 Chk2 O96017 human beclin 1 8678 Q14457 BECN1 human S90 472001 IPPARMMstEsANsF X X 29362; 86455 +CHEK2 Chk2 O96017 human TIF1B 21849 Q62318 Trim28 mouse S473 452391 SGMkRsRsGEGEVSG X +CHEK2 Chk2 O96017 human MDM4 4194 O15151 MDM4 human S367 457676 PDCRRtIsAPVVRPk X X +CHEK2 Chk2 O96017 human p53 7157 P04637 TP53 human S366 455223 PGGsRAHssHLkskk X X +CHEK2 Chk2 O96017 human E2F3 1871 O00716 E2F3 human S124 11929101 PALGrGGsGGGGGPP X +CHEK2 Chk2 O96017 human Chk2 11200 O96017 CHEK2 human S260 447554 KRKFAIGsAREADPA Pkinase X +CHEK2 Chk2 O96017 human SIAH2 6478 O43255 SIAH2 human T26 5393503 PPPQPQHtPsPAAPP X +CHEK2 Chk2 O96017 human FOXM1 iso2 2305 Q08050-2 FOXM1 human S361 471396 PLLPRVSsYLVPIQF X X +CHEK2 Chk2 O96017 human XRCC1 7515 P18887 XRCC1 human S184 5014907 EEDESANsLRPGALF X +CHEK2 Chk2 O96017 human CDC25A 993 P30304 CDC25A human S124 449127 PALkRSHsDsLDHDI M-inducer_phosp X X +CHEK2 Chk2 O96017 human INCENP 3619 Q9NQS7 INCENP human S91 4273495 RRLSRRKsRssQLsS X X +CHEK2 Chk2 O96017 human Chk2 11200 O96017 CHEK2 human S140 6339800 TDKYRTYsKKHFRIF FHA X +CHEK2 Chk2 O96017 human Chk2 11200 O96017 CHEK2 human S516 448840 PQVLAQPstSRkRPR X X 2669 +CHEK2 Chk2 O96017 human PSME3 10197 P61289 PSME3 human S247 15413789 EKIKRPRssNAETLy PA28_beta X X +CHEK2 Chk2 O96017 human CDC25A 993 P30304 CDC25A human S178 449126 LFTQRQNsAPARMLs M-inducer_phosp X +CHEK2 Chk2 O96017 human p53 7157 P04637 TP53 human S20 447529 PLsQEtFsDLWkLLP P53_TAD X X 9287 +CHEK2 Chk2 O96017 human CDK11B 984 P21127 CDK11B human S752 468448 QRVKRGtsPRPPEGG X X +CHEK2 Chk2 O96017 human LATS2 26524 Q9NRM7 LATS2 human S172 4744563 TPVtRRPsFEGTGDS X +CHEK2 Chk2 O96017 human RBM28 55131 Q9NW13 RBM28 human S122 3245387 RLIIRNLsFKCSEDD RRM_1 X +CHEK2 Chk2 O96017 human Chk2 11200 O96017 CHEK2 human S35 447550 sQGSSsQsQGIssss X 2665 +CHEK2 Chk2 O96017 human BLM 641 P54132 BLM human T182 41290000 sHFVRVStAQKSKKG BLM_N X X +CHEK2 Chk2 O96017 human H1C 3006 P16403 H1-2 human S36 450120 GGtPRkAsGPPVsEL X +CHEK2 Chk2 O96017 human p53 7157 P04637 TP53 human S378 447534 skkGQstsRHkkLMF X +CHEK2 Chk2 O96017 human Chk2 11200 O96017 CHEK2 human T68 447491 SsLEtVstQELYsIP X X 2197; 2661; 28130; 12812; 82263; 64180; 59068 +CHEK2 Chk2 O96017 human TIF1B 10155 Q13263 TRIM28 human S473 452391 sGVkRsRsGEGEVsG X +CHEK2 Chk2 O96017 human PKM 5315 P14618 PKM human S100 4708572 tAtEsFAsDPILyRP PK X X +CHEK2 Chk2 O96017 human HuR 1994 Q15717 ELAVL1 human S100 474553 VSYARPSsEVIkDAN X X +CHEK2 Chk2 O96017 human MDM4 4194 O15151 MDM4 human S342 470031 SkLTHSLsTSDITAI X X +CHEK2 Chk2 O96017 human Chk2 11200 O96017 CHEK2 human T387 447552 LMRtLCGtPtyLAPE Pkinase X X +CHEK2 Chk2 O96017 human Chk2 11200 O96017 CHEK2 human S379 981401 skILGEtsLMRtLCG Pkinase X X +CHEK2 Chk2 O96017 human ULK1 8408 O75385 ULK1 human S556 3176155 GLGCRLHsAPNLsDL X X 5869 +CHEK2 Chk2 O96017 human Chk2 11200 O96017 CHEK2 human T432 447553 PPFSEHRtQVsLkDQ Pkinase X +CHEK2 Chk2 O96017 human H1C 3006 P16403 H1-2 human S89 487417 LGLksLVskGtLVQT Linker_histone X +CHEK2 Chk2 O96017 human p53 7157 P04637 TP53 human S15 447490 PsVEPPLsQEtFsDL P53_TAD X 4030; 9235; 9284; 9286; 8695; 8514; 82530; 56979 +CHEK2 Chk2 O96017 human BDNF 627 P23560 BDNF human T62 30259809 GLTSLADtFEHVIEE X +CHEK2 Chk2 O96017 human Chk2 11200 O96017 CHEK2 human S120 1065318 YWFGRDksCEYCFDE FHA X +CHEK2 Chk2 O96017 human AATF 26574 Q9NY61 AATF human S477 3753303 ELIERkTsSLDPNDQ TRAUB X +CHEK2 Chk2 O96017 human SIAH2 6478 O43255 SIAH2 human S28 471339 PQPQHtPsPAAPPAA X X +CHEK2 Chk2 O96017 human Chk2 11200 O96017 CHEK2 human T225 2811405 DEYIMSktLGSGACG Pkinase X +CHEK2 Chk2 O96017 human CDC25A 993 P30304 CDC25A human S293 449128 GSTKrRKsMsGASPk M-inducer_phosp X +CHEK2 Chk2 O96017 human HuR 1994 Q15717 ELAVL1 human S88 474552 LNGLRLQskTIkVSY RRM_1 X X +CHEK2 Chk2 O96017 human MBP 618684 P02687 MBP cow T18 487421 KYLASAstMDHARHG Myelin_MBP X +CHEK2 Chk2 O96017 human MBP 618684 P02687 MBP cow T148 487419 KGHDAQGtLsKIFKL Myelin_MBP X +CHEK2 Chk2 O96017 human Chk2 11200 O96017 CHEK2 human T383 447545 GEtsLMRtLCGtPty Pkinase X X +ROR1 ROR1 Q01973 human HER3 2065 P21860 ERBB3 human Y1307 454901 HQAPHVHyARLKtLR X X +CAMK2D CAMK2D Q13557 human PKM 18746 P52480 Pkm mouse T454 23132420 RAPIIAVtRNPQTAR PK_C X X +CAMK2D CAMK2D Q13557 human HDAC4 9759 P56524 HDAC4 human S210 2631600 YGKTQHSsLDQSsPP X X +CAMK2D CAMK2D Q13557 human BMAL1 11865 Q9WTL8 Bmal1 mouse S519 1878257202 IHRIRGSsPssCGSS X +CAMK2D CAMK2D Q13557 human SCN5A 6331 Q14524 SCN5A human T594 25244201 LHGkKNStVDCNGVV Na_trans_cytopl X +CAMK2D CAMK2D Q13557 human Kv7.1 3784 P51787 KCNQ1 human T482 783280700 sMPHFMRtNsFAEDL X X +CAMK2D CAMK2D Q13557 human Kir6.2 3767 Q14654 KCNJ11 human T224 453090 MQVVRKTtSPEGEVV IRK_C X X +CAMK2D CAMK2D Q13557 human IP3R2 P29995 Itpr2 rat S150 26415703 EKNAMRVsLDAAGNE Ins145_P3_rec X +CAMK2D CAMK2D Q13557 human BMAL1 11865 Q9WTL8 Bmal1 mouse S522 1878257206 IRGSsPssCGSSPLN X +CAMK2D CAMK2D Q13557 human ANKRD28 23243 O15084 ANKRD28 human S1011 459225 TNTskTVsFEALPIM X +CAMK2D CAMK2D Q13557 human PLB 18821 P61014 Pln mouse T17 448115 SAIRRAstIEMPQQA Phospholamban X 8496 +CAMK2D CAMK2D Q13557 human RNF8 9025 O76064 RNF8 human S157 3177751 LRTKRkFsLDELAGP X +CAMK2D CAMK2D Q13557 human Titin 7273 Q8WZ42 TTN human T11922 27463601 EVEVPTVtKRERKIP X +CAMK2D CAMK2D Q13557 human CACNB2 iso2 783 Q08289-2 CACNB2 human T499 470081 RGLSRQEtFDSETQE X +CAMK2D CAMK2D Q13557 human Kv7.1 3784 P51787 KCNQ1 human S484 40556220 PHFMRtNsFAEDLDL KCNQ_channel X X +CAMK2D CAMK2D Q13557 human BMAL1 11865 Q9WTL8 Bmal1 mouse S521 1878257204 RIRGSsPssCGSSPL X +CAMK2D CAMK2D Q13557 human CEACAM1 iso8 634 P13688-8 CEACAM1 human S459 3439800 LHFGKtGsSGPLQ__ X +CAMK2D CAMK2D Q13557 human Titin 7273 Q8WZ42 TTN human S12022 4693667 RRKLRPGsGGEKPPD X +CAMK2D CAMK2D Q13557 human SCN5A 6331 Q14524 SCN5A human S516 4719558 LsLTrGLsRTsMKPR Na_trans_cytopl X +CAMK2D CAMK2D Q13557 human Titin 7273 Q8WZ42 TTN human T11932 27429703 ERKIPEPtKVPEIKP X +CAMK2D CAMK2D Q13557 human Titin 7273 Q8WZ42 TTN human T11969 27429704 PPVEPEPtPIAAPVT X +CAMK2D CAMK2D Q13557 human CAMK2D 817 Q13557 CAMK2D human T287 450982 sMMHRQEtVDCLKKF X 12716 +CAMK2D CAMK2D Q13557 human PPP3CA 24674 P63329 Ppp3ca rat S411 2048309 GKMARVFsVLREESE X +CAMK2D CAMK2D Q13557 human RYR2 20191 E9Q401 Ryr2 mouse S2813 458801 IsQtsQVsIDAAHGY X X +CAMK2D CAMK2D Q13557 human occludin 100506658 Q16625 OCLN human S471 6094301 LDDyREEsEEyMAAA Occludin_ELL X +CAMK2D CAMK2D Q13557 human CAMK2B 816 Q13554 CAMK2B human T287 450048 sMMHRQEtVECLKKF X 12716 +CAMK2D CAMK2D Q13557 human CEACAM1 iso8 634 P13688-8 CEACAM1 human T457 3439801 CFLHFGKtGsSGPLQ X X +CAMK2D CAMK2D Q13557 human Titin 7273 Q8WZ42 TTN human S11878 10029600 KEEVVLKsVLRKRPE X +GRK6 GRK6 P43250 human CXCR4 7852 P61073 CXCR4 human S324 6140803 LtsVsRGssLkILsk X 85578 +GRK6 GRK6 P43250 human GRK6 2870 P43250 GRK6 human S484 467963 VLDIEQFstVkGVEL X +GRK6 GRK6 P43250 human ADRB2 11555 P18762 Adrb2 mouse S355 458916 KTYGNGYssNSNGRT X +GRK6 GRK6 P43250 human GRK6 2870 P43250 GRK6 human T485 467964 LDIEQFstVkGVELE X +GRK6 GRK6 P43250 human ADRB2 11555 P18762 Adrb2 mouse S356 458917 TYGNGYssNSNGRTD X +GRK6 GRK6 P43250 human IGF1R 3480 P08069 IGF1R human S1321 25240303 LPLPDRHsGHKAENG X +GRK6 GRK6 P43250 human ADRB2 154 P07550 ADRB2 human S355 458916 KAyGNGyssNGNtGE X X +GRK6 GRK6 P43250 human CXCR4 7852 P61073 CXCR4 human S325 3849622 tsVsRGssLkILskG X 85578 +GRK6 GRK6 P43250 human LTB4R 1241 Q15722 LTB4R human T308 455505 VAKLLEGtGsEAsst X +GRK6 GRK6 P43250 human ADRB2 154 P07550 ADRB2 human S356 458917 AyGNGyssNGNtGEQ X X +GRK6 GRK6 P43250 human NHERF 9368 O14745 NHERF1 human S290 450313 PALVRsAssDtsEEL EBP50_C X +GRK6 GRK6 P43250 human occludin 100506658 Q16625 OCLN human S471 6094301 LDDyREEsEEyMAAA Occludin_ELL X +GRK6 GRK6 P43250 human NHERF 100009196 Q28619 SLC9A3R1 rabbit S289 450313 PALARsAssDTSEEL EBP50_C X X +Ntrk1 TrkA Q3UFB7 mouse APP 11820 P12023 App mouse Y757 448202 SkMQQNGyENPTykF APP_amyloid X +PRKCA PKCA P04409 cow TNNI3 511094 P08057 TNNI3 cow S44 450690 AKKKSKIsAsRKLQL X +PRKCA PKCA P04409 cow Rhodopsin 509933 P02699 RHO cow T336 3091410 GDDEAsttVsKtEts X +PRKCA PKCA P04409 cow TNNT2 286816 P13789 TNNT2 cow S195 451755 KAQtERKsGKRQtER Troponin X +PRKCA PKCA P04409 cow ANXA2 302 P07355 ANXA2 human S26 450879 tPPsAyGsVkAytNF X +PRKCA PKCA P04409 cow TNNI3 511094 P08057 TNNI3 cow S25 448424 PPVRRRssANYRAYA Troponin-I_N X +PRKCA PKCA P04409 cow ANXA1 327662 P46193 ANXA1 cow T24 452052 EEQEYIKtVKGsKGG X +PRKCA PKCA P04409 cow CD3G 917 P09693 CD3G human S145 12522600 GQDGVRQsRAsDkQT X +PRKCA PKCA P04409 cow RGS9 281453 O46469 RGS9 cow S475 449027 MSKLDRRsQLRKEPP X +PRKCA PKCA P04409 cow ADD2 119 P35612 ADD2 human S726 449803 KKKEKVEs_______ X +PRKCA PKCA P04409 cow IREB1 50655 Q63270 Aco1 rat S138 451387 HFNRRADsLQkNQDL Aconitase X +PRKCA PKCA P04409 cow AMPKA1 5562 Q13131 PRKAA1 human S496 450431 AtPQRsGsVsNyRSC AdenylateSensor X 4185; 4184; 2537 +PRKCA PKCA P04409 cow MRLC2 67938 Q3THE2 Myl12b mouse S2 448593 ______MssKKAKTK X +PRKCA PKCA P04409 cow H2B 615043 P62808 H2BC19 cow S32 447801 DGKKRKRsRKEsYSV Histone X +PRKCA PKCA P04409 cow Rhodopsin 509933 P02699 RHO cow S334 448677 PLGDDEAsttVsKtE X +PRKCA PKCA P04409 cow STXBP1 25558 P61765 Stxbp1 rat S306 448743 VSQEVTRsLkDFSSs Sec1 X +PRKCA PKCA P04409 cow ADD1 24170 Q63028 Add1 rat S724 449829 KKKFRTPsFLKKSKK X +PRKCA PKCA P04409 cow FGF2 2247 P09038 FGF2 human S206 451678 AEERGVVsIKGVCAN FGF X +PRKCA PKCA P04409 cow EIF4E 13684 P63073 Eif4e mouse S209 447776 DTATKSGsttKNRFV X 9741 +PRKCA PKCA P04409 cow eNOS 287024 P29473 NOS3 cow T497 447885 AGITRKktFKEVANA X +PRKCA PKCA P04409 cow TNNI3 511094 P08057 TNNI3 cow S46 450691 KKSKIsAsRKLQLKT X +PRKCA PKCA P04409 cow IREB1 100009154 Q01059 ACO1 rabbit S711 455225 REFNSYGsRRGNDAI Aconitase_C X +PRKCA PKCA P04409 cow PIK3R1 282307 P23727 PIK3R1 cow T86 22881800 RKKIsPPtPKPRPPR X +PRKCA PKCA P04409 cow Lamin B2 P14732 LMNB2 chicken S410 20657002 SsTSLVRssRGKRRR X +PRKCA PKCA P04409 cow TNNT2 286816 P13789 TNNT2 cow T200 451556 RKsGKRQtEREKKKK Troponin X +PRKCA PKCA P04409 cow ANXA2 282689 P04272 ANXA2 cow S26 450879 TPPSAyGsVKAYTNF X +PRKCA PKCA P04409 cow GJB1 29584 P08033 Gjb1 rat S233 451163 NPPSRKGsGFGHRLs X X +PRKCA PKCA P04409 cow MRLC1 10398 P24844 MYL9 human S3 4964100 _____MssKRAKAKt X +PRKCA PKCA P04409 cow MARCKS 4082 P29966 MARCKS human S159 447786 kkKKKRFsFkKsFkL MARCKS X 2741; 11992 +PRKCA PKCA P04409 cow Rhodopsin 509933 P02699 RHO cow S343 448680 tVsKtEtsQVAPA__ X +PRKCA PKCA P04409 cow MRLC1 10398 P24844 MYL9 human T10 4964102 sKRAKAKttKKRPQR X +PRKCA PKCA P04409 cow GAP43 281777 P06836 GAP43 cow S41 448719 AATKIQAsFRGHITR IQ X +PRKCA PKCA P04409 cow PDE6G 281977 P04972 PDE6G cow T35 450149 PKFKQRQtRQFKSKP PDE6_gamma X +PRKCA PKCA P04409 cow TNNI3 511094 P08057 TNNI3 cow S24 448423 PPPVRRRssANYRAY Troponin-I_N X +PRKCA PKCA P04409 cow Lamin B2 P14732 LMNB2 chicken S411 20657001 sTSLVRssRGKRRRI X +PRKCA PKCA P04409 cow ASS1 280726 P14568 ASS1 cow S328 25589104 VYTGFWHsPECEFVR Arginosuc_synth X +PRKCA PKCA P04409 cow ADD2 24171 Q05764 Add2 rat S712 449802 KKKFRTPsFLKKSKK X +PRKCA PKCA P04409 cow ANXA1 327662 P46193 ANXA1 cow S28 452053 YIKtVKGsKGGPGSA X +PRKCA PKCA P04409 cow INSR 3643 P06213 INSR human T1375 450327 KKNGRILtLPRSNPS X +PRKCA PKCA P04409 cow IREB1 48 P21399 ACO1 human S711 455225 REFNSYGsRrGNDAV Aconitase_C X +PRKCA PKCA P04409 cow H1C 513971 P02253 H1-2 cow S36 450120 AGARRKAsGPPVSEL X +PRKCA PKCA P04409 cow GJA1 24392 P08050 Gja1 rat S368 447813 QRPssRAssRAssRP X 3511; 52559 +PRKCA PKCA P04409 cow TNNI3 511094 P08057 TNNI3 cow T145 451483 RGKFKRPtLRRVRIS Troponin X +PRKCA PKCA P04409 cow ADRA1B 101843941 P18841 ADRA1B hamster S400 451003 GsLERSQsRKDsLDD X +PRKCA PKCA P04409 cow ADRA1B 101843941 P18841 ADRA1B hamster S394 451002 RPWTRGGsLERSQsR X +PRKCA PKCA P04409 cow MRLC1 10398 P24844 MYL9 human S20 1863500 KRPQRAtsNVFAMFD X 3674; 3671; 3675; 95777 +PRKCA PKCA P04409 cow ADD2 119 P35612 ADD2 human S713 449802 KKKFRtPsFLKKsKK X +PRKCA PKCA P04409 cow ADD1 118 P35611 ADD1 human S726 449829 KKKFRtPsFLKKsKK X +PRKCA PKCA P04409 cow MRLC1 10398 P24844 MYL9 human S2 4964101 ______MssKRAKAK X +PRKCA PKCA P04409 cow TNNT2 286816 P13789 TNNT2 cow T281 451557 TRGKAKVtGRWK___ X +PRKCA PKCA P04409 cow STXBP1 25558 P61765 Stxbp1 rat S313 448744 sLkDFSSsKRMNTGE Sec1 X +PRKCA PKCA P04409 cow ADD2 24171 Q05764 Add2 rat S725 449803 KKKEKVEs_______ X +PRKCA PKCA P04409 cow Rhodopsin 509933 P02699 RHO cow S338 448679 DEAsttVsKtEtsQV X +PRKCA PKCA P04409 cow IREB1 48 P21399 ACO1 human S138 451387 DFNRRADsLQkNQDL Aconitase X +PRKCA PKCA P04409 cow CD3G 917 P09693 CD3G human S148 451430 GVRQsRAsDkQTLLP X +PRKCA PKCA P04409 cow H2B 615043 P62808 H2BC19 cow S36 449903 RKRsRKEsYSVYVYK Histone X +PRKCA PKCA P04409 cow Rhodopsin 509933 P02699 RHO cow T335 10433600 LGDDEAsttVsKtEt X +PRKCA PKCA P04409 cow ADD1 118 P35611 ADD1 human S716 449828 GsPGKsPsKKKKKFR X +PRKCA PKCA P04409 cow ADD1 24170 Q63028 Add1 rat S714 449828 GSPGKSPsKKKKKFR X +STK17B DRAK2 O94768 human STAT5A 20850 P42230 Stat5a mouse S779 448750 DsLDARLsPPAGLFT X +Raf1 RAF1 Q99N57 mouse MEK1 5604 Q02750 MAP2K1 human S222 448513 LIDsMANsFVGtRSY Pkinase X 2338; 9121; 3958; 9154; 16211; 86128; 16780; 75262 +Raf1 RAF1 Q99N57 mouse MEK1 5604 Q02750 MAP2K1 human S218 448514 VsGQLIDsMANsFVG Pkinase X 9121; 3958; 9154; 86128 +Raf1 RAF1 Q99N57 mouse RAF1 110157 Q99N57 Raf1 mouse S621 447746 PKINRsAsEPsLHRA X +STK25 YSK1 O00506 human PKAR1A 5573 P10644 PRKAR1A human S83 450936 DsREDEIsPPPPNPV X X +STK25 YSK1 O00506 human CCM2 83605 Q9BSQ5 CCM2 human S384 467352 GRGIITDsFGRHRRA CCM2_C X +STK25 YSK1 O00506 human PDCD10 11235 Q9BUL8 PDCD10 human T43 7452901 VNLsAAQtLRAAFIk DUF1241 X X +STK25 YSK1 O00506 human PDCD10 11235 Q9BUL8 PDCD10 human S39 7452900 ELERVNLsAAQtLRA DUF1241 X X +STK25 YSK1 O00506 human PKAR1A 5573 P10644 PRKAR1A human S77 468450 kAGtRtDsREDEIsP X X +FLT1 VEGFR1 P17948 human VEGFR1 2321 P17948 FLT1 human Y1327 448211 CCSPPPDyNSVVLyS X +FLT1 VEGFR1 P17948 human VEGFR1 2321 P17948 FLT1 human Y1213 448209 GsSDDVRyVNAFKFM X X +FLT1 VEGFR1 P17948 human GLO1 2739 Q04760 GLO1 human Y136 463450 GIAVPDVysACkRFE Glyoxalase X +FLT1 VEGFR1 P17948 human VEGFR1 2321 P17948 FLT1 human Y1169 448208 VQQDGKDyIPINAIL X X +FLT1 VEGFR1 P17948 human VEGFR1 2321 P17948 FLT1 human Y1333 448212 DyNSVVLySTPPI__ X +FLT1 VEGFR1 P17948 human VEGFR1 2321 P17948 FLT1 human Y1242 448210 ATSMFDDyQGDSSTL X +Mapkapk2 MAPKAPK2 Q80ZF4 rat skMLCK 117558 P20689 Mylk2 rat S168 2864200 PAFLHsPsCPAIISC X +Src Src iso1 P05480-1 mouse Vimentin 22352 P20152 Vim mouse Y61 448931 sssPGGAyVtRssAV Filament_head X +Src Src iso1 P05480-1 mouse TRIP6 22051 Q9Z1Y4 Trip6 mouse Y55 456050 PLPPEHCyQPPGVPE X +Src Src iso1 P05480-1 mouse NCAM-L1 50687 Q05695 L1cam rat Y1153 466002 KRSKGGKysVKDKED Bravo_FIGEY X +Src Src iso1 P05480-1 mouse FAK 14083 P34152 Ptk2 mouse Y407 447888 IIDEEDtytMPSTRD X +Src Src iso1 P05480-1 mouse PRDX1 18477 P35700 Prdx1 mouse Y194 448924 DVnkSkEyFsKQK__ 1-cysPrx_C X +Src Src iso1 P05480-1 mouse FAK 14083 P34152 Ptk2 mouse Y576 447889 RyMEDstyyKASKGK PK_Tyr_Ser-Thr X 3281 +Src Src iso1 P05480-1 mouse DAG1 13138 Q62165 Dag1 mouse Y890 449630 PyRsPPPyVPP____ DAG1 X 32248 +Src Src iso1 P05480-1 mouse CDH2 12558 P15116 Cdh2 mouse Y884 450693 SSGGDQDyDYLNDWG CADH_Y-type_LIR X +Src Src iso1 P05480-1 mouse Src iso1 20779 P05480-1 Src mouse Y424 448234 RLIEDNEytARQGAK PK_Tyr_Ser-Thr X 2101; 6943; 59548; 70926; 78740; 94361; 17320 +Src Src iso1 P05480-1 mouse ephexin-1 53972 Q8CHT1 Ngef mouse Y177 455579 IEQIGLLyQEyRDKS X +Src Src iso1 P05480-1 mouse CTNNB1 12387 Q02248 Ctnnb1 mouse Y86 447584 VADIDGQyAMTRAQR X +Src Src iso1 P05480-1 mouse Akt1 11651 P31750 Akt1 mouse Y315 448519 tFCGtPEyLAPEVLE Pkinase X X +Src Src iso1 P05480-1 mouse NMDAR2B 14812 Q01097 Grin2b mouse Y1472 448167 GSSNGHVyEKLSSIE NMDAR2_C X 4208 +Src Src iso1 P05480-1 mouse KHDRBS3 13992 Q9R226 Khdrbs3 mouse S15 13196100 ELMAEKDsLDPSFTH Qua1 X +Src Src iso1 P05480-1 mouse ZDHHC3 69035 Q8R173 Zdhhc3 mouse Y297 56580000 GKADPyQyVV_____ X +Src Src iso1 P05480-1 mouse GIRK1 16519 P63250 Kcnj3 mouse Y12 457610 RRKFGDDyQVVTTSS X +Src Src iso1 P05480-1 mouse MTSS1 211401 Q8R1S4 Mtss1 mouse Y397 463827 HLPDYAHyyTIGPGM X X +Src Src iso1 P05480-1 mouse Cortactin 13043 Q60598 Cttn mouse Y421 447702 RPPssPIyEDAAPFK X X 4569 +Src Src iso1 P05480-1 mouse EZH2 14056 Q61188 Ezh2 mouse Y696 463307 HSVNPNCyAKVMMVN SET X +Src Src iso1 P05480-1 mouse CTNND1 12388 P30999 Ctnnd1 mouse Y228 449648 yPGGsDNyGsLsRVT X X 2911 +Src Src iso1 P05480-1 mouse LPIN1 23175 Q14693 LPIN1 human Y795 1871177712 FPNTEPFyAAFGNRP LNS2 X +Src Src iso1 P05480-1 mouse DDEF1 13196 Q9QWY8 Asap1 mouse Y308 450437 PKEVGGLyVASRANS X +Src Src iso1 P05480-1 mouse PKCD 18753 P28867 Prkcd mouse Y187 447579 WGLNkQGyKCRQCNA C1_1 X +Src Src iso1 P05480-1 mouse nectin 2 19294 P32507 Nectin2 mouse Y505 3971844 LDKINPIyDALSYPS X +Src Src iso1 P05480-1 mouse MOR-1 18390 P42866 Oprm1 mouse Y336 5397200 SCLNPVLyAFLDENF 7tm_1 X +Src Src iso1 P05480-1 mouse IGF1R 16001 Q60751 Igf1r mouse Y974 449827 RLGNGVLyASVNPEy X X +Src Src iso1 P05480-1 mouse LPIN1 23175 Q14693 LPIN1 human Y413 1871177711 DPEVAALyFPKNGDP X +Src Src iso1 P05480-1 mouse ARHGEF7 54126 Q9ES28 Arhgef7 mouse Y755 1443172900 DLsEDSEyDSIWTAH X +Src Src iso1 P05480-1 mouse EGFR 1956 P00533 EGFR human Y1092 448057 tFLPVPEyINQsVPk X 2236; 2234; 3777; 14565; 8543; 48576 +Src Src iso1 P05480-1 mouse CTNNB1 12387 Q02248 Ctnnb1 mouse Y654 447585 RNEGVATyAAAVLFR X +Src Src iso1 P05480-1 mouse CTNND1 12388 P30999 Ctnnd1 mouse Y302 450177 DyGMMsDyGtARRtG X X +Src Src iso1 P05480-1 mouse IGF1R 16001 Q60751 Igf1r mouse Y981 448390 yASVNPEyFSAADVY X X 4568 +Src Src iso1 P05480-1 mouse TGFBR2 7048 P37173 TGFBR2 human Y284 479864 KIFPYEEyASWKTEk PK_Tyr_Ser-Thr X +Src Src iso1 P05480-1 mouse PKCD 18753 P28867 Prkcd mouse Y332 450077 ILDNNGTyGKIWEGS X X +Src Src iso1 P05480-1 mouse CTNND1 12388 P30999 Ctnnd1 mouse Y296 450176 MGyDDLDyGMMsDyG X X +Src Src iso1 P05480-1 mouse IGF1R 16001 Q60751 Igf1r mouse Y1167 448387 RDIyEtDyyRKGGkG PK_Tyr_Ser-Thr X 3024; 3918; 2969 +Src Src iso1 P05480-1 mouse Cortactin 13043 Q60598 Cttn mouse Y482 447704 yQAEDDTyDGYESDL X +Src Src iso1 P05480-1 mouse DNAJB4 67035 Q9D832 Dnajb4 mouse Y172 450786 KVSLEEIySGCTKRM DnaJ_C X +Src Src iso1 P05480-1 mouse TLR3 364594 Q7TNI8 Tlr3 rat Y760 450187 EQFEYTAyIIHAQKD TIR X +Src Src iso1 P05480-1 mouse Pyk2 19229 Q9QVP9 Ptk2b mouse Y881 447958 DRTDDLVyHNVMTLV Focal_AT X +Src Src iso1 P05480-1 mouse ACP1 280977 Q3SZ94 ACP1 cow Y132 450718 QLIIEDPyyGNDADF LMWPc X +Src Src iso1 P05480-1 mouse Cortactin 13043 Q60598 Cttn mouse Y475 3973973 TTEAPGHyQAEDDTy X +Src Src iso1 P05480-1 mouse APP iso2 11820 P12023-2 App mouse Y682 448202 SkMQQNGyENPTykF APP_amyloid X +Src Src iso1 P05480-1 mouse TBK1 29110 Q9UHD2 TBK1 human Y179 23151249 sLyGTEEyLHPDMYE Pkinase X +Src Src iso1 P05480-1 mouse PXN 19303 Q8VI36 Pxn mouse Y118 448604 AGEEEHVysFPNKQk Paxillin X 2541; 69363 +Src Src iso1 P05480-1 mouse PLCG1 18803 Q62077 Plcg1 mouse Y783 447667 EGRNPGFyVEANPMP X 2821; 14461; 14008; 25678; 88717 +Src Src iso1 P05480-1 mouse IGF1R 16001 Q60751 Igf1r mouse Y1163 448386 FGMTRDIyEtDyyRK PK_Tyr_Ser-Thr X X 3021; 80732 +Src Src iso1 P05480-1 mouse IGF1R 16001 Q60751 Igf1r mouse Y1352 448389 sFDERQPyAHMNGGR X X 28897 +Src Src iso1 P05480-1 mouse STAT3 20848 P42227 Stat3 mouse Y705 448192 DPGsAAPyLktkFIC X 4093; 9145; 4324; 9131; 9138; 4323; 4074; 4113; 48313; 20977; 25023; 8119; 52075; 52527; 73533; 61958; 73452; 16185; 74309 +Src Src iso1 P05480-1 mouse CDH2 12558 P15116 Cdh2 mouse Y852 450692 NDPTAPPyDSLLVFD CADH_Y-type_LIR X +Src Src iso1 P05480-1 mouse CTNND1 12388 P30999 Ctnnd1 mouse Y112 472275 PGQIVETyTEEDPEG X X +Src Src iso1 P05480-1 mouse TLR3 142980 Q99MB1 Tlr3 mouse Y760 450187 EQFEYTAyIIHAHkD TIR X +Src Src iso1 P05480-1 mouse FAK 14083 P34152 Ptk2 mouse Y397 447887 sVsEtDDyAEIIDEE X 3283; 8556 +Src Src iso1 P05480-1 mouse PKHF1 72287 Q3TB82 Plekhf1 mouse Y208 1868624702 LRVCSLCyRELAAQK FYVE X +Src Src iso1 P05480-1 mouse Akt1 11651 P31750 Akt1 mouse Y326 447858 EVLEDNDyGRAVDWW Pkinase X X +Src Src iso1 P05480-1 mouse Ezrin 7430 P15311 EZR human Y478 454875 PPPPPPVyEPVsyHV X +Src Src iso1 P05480-1 mouse ZDHHC3 69035 Q8R173 Zdhhc3 mouse Y295 464577 DQGKADPyQyVV___ X +Src Src iso1 P05480-1 mouse DAB1 13131 P97318 Dab1 mouse Y220 447630 PETEENIyQVPTSQK X 3327 +Src Src iso1 P05480-1 mouse Vimentin 22352 P20152 Vim mouse Y117 450350 LNDRFANyIDkVRFL Filament X +Src Src iso1 P05480-1 mouse FAK 14083 P34152 Ptk2 mouse Y577 447890 yMEDstyyKASKGKL PK_Tyr_Ser-Thr X 3281 +Src Src iso1 P05480-1 mouse Vimentin 22352 P20152 Vim mouse Y53 448930 PstsRsLysssPGGA Filament_head X +Src Src iso1 P05480-1 mouse EGFR 13649 Q01279 Egfr mouse Y871 448061 LGAEEkEyHAEGGkV PK_Tyr_Ser-Thr X 2231; 6963 +Src Src iso1 P05480-1 mouse PKCD 18753 P28867 Prkcd mouse Y311 447573 TTEsVGIyQGFEKKP X X 2055 +Src Src iso1 P05480-1 mouse EGFR 1956 P00533 EGFR human Y869 448061 LGAEEkEyHAEGGkV PK_Tyr_Ser-Thr X 2231; 6963 +Src Src iso1 P05480-1 mouse EFNB1 13641 P52795 Efnb1 mouse Y328 448343 GDyGHPVyIVQEMPP X 3481 +Src Src iso1 P05480-1 mouse PKCD 18753 P28867 Prkcd mouse Y155 447575 IKQAKIHyIKNHEFI X +Src Src iso1 P05480-1 mouse IGF1R 16001 Q60751 Igf1r mouse Y1168 448388 DIyEtDyyRKGGkGL PK_Tyr_Ser-Thr X X 3024; 2969 +Src Src iso1 P05480-1 mouse PXN 19303 Q8VI36 Pxn mouse Y31 448785 FLsEEPPysyPTGNH X +Src Src iso1 P05480-1 mouse CTNND1 12388 P30999 Ctnnd1 mouse Y280 450398 HRFHPEPyGLEDDQR X X +Src Src iso1 P05480-1 mouse ACP1 280977 Q3SZ94 ACP1 cow Y133 457445 LIIEDPyyGNDADFE LMWPc X +Src Src iso1 P05480-1 mouse CTNND1 12388 P30999 Ctnnd1 mouse Y291 450175 DDQRsMGyDDLDyGM X X +Src Src iso1 P05480-1 mouse UGCG 22234 O88693 Ugcg mouse Y132 26420454 INNLMPAyEVAKYDL Glyco_transf_21 X +Src Src iso1 P05480-1 mouse Kit 3815 P10721 KIT human Y900 450042 EHAPAEMyDIMKTCW PK_Tyr_Ser-Thr X X +Src Src iso1 P05480-1 mouse RAF1 110157 Q99N57 Raf1 mouse Y341 447750 GQRDssyyWEIEASE X +Src Src iso1 P05480-1 mouse Moesin 4478 P26038 MSN human T558 447706 LGRDKyKtLRQIRQG ERM_C X 3141; 3726; 32600 +Src Src iso1 P05480-1 mouse emerin 13726 O08579 Emd mouse Y75 451787 AAVDSDMyDLPKkED X +Src Src iso1 P05480-1 mouse Ret 5979 P07949 RET human Y905 447627 DVyEEDsyVKRsQGR PK_Tyr_Ser-Thr X 3221 +Src Src iso1 P05480-1 mouse PKHF1 72287 Q3TB82 Plekhf1 mouse Y268 1868624701 WPTQVEFyASGVSWS X +Src Src iso1 P05480-1 mouse Cortactin 13043 Q60598 Cttn mouse Y466 447703 TyTSEPVyETTEAPG X X +Src Src iso1 P05480-1 mouse IkB-alpha 4792 P25963 NFKBIA human Y42 448737 DsMkDEEyEQMVkEL X +Src Src iso1 P05480-1 mouse emerin 13726 O08579 Emd mouse Y96 448938 kDYNDDyyEESYLTT X +Src Src iso1 P05480-1 mouse LPIN1 23175 Q14693 LPIN1 human Y398 1871177710 HLGADGVyLDDLTDM X +Src Src iso1 P05480-1 mouse P130Cas 12927 Q61140 Bcar1 mouse Y668 448399 EGGWMEDyDyVHLQG CAS_C X +Src Src iso1 P05480-1 mouse Pyk2 19229 Q9QVP9 Ptk2b mouse Y402 447955 CSIESDIyAEIPDET X 3291 +Src Src iso1 P05480-1 mouse SPRY2 24064 Q9QXV8 Spry2 mouse Y55 448849 AIRNTNEyTEGPTVV X +Src Src iso1 P05480-1 mouse ROBO3 19649 Q9Z2I4 Robo3 mouse Y1019 37043702 ASGEGPVySTIDPVG X +Src Src iso1 P05480-1 mouse caveolin-1 12389 P49817 Cav1 mouse Y14 448422 VDsEGHLytVPIREQ X 3251 +Src Src iso1 P05480-1 mouse STXBP1 20910 O08599 Stxbp1 mouse Y473 450386 ERISEQTyQLSRWtP Sec1 X +Src Src iso1 P05480-1 mouse Src 6714 P12931 SRC human Y419 448234 RLIEDNEytARQGAk PK_Tyr_Ser-Thr X 2101; 6943; 59548; 70926; 78740; 94361; 17320 +Src Src iso1 P05480-1 mouse ROCK2 19878 P70336 Rock2 mouse Y722 464192 LADKNKIyEsIEEAK X +Src Src iso1 P05480-1 mouse CTNND1 12388 P30999 Ctnnd1 mouse Y96 449495 QDHNHLLystIPRMQ X X +Src Src iso1 P05480-1 mouse PTPRA 19262 P18052 Ptpra mouse Y825 447613 YIDAFsDyANFK___ X X 4481 +Src Src iso1 P05480-1 mouse CTNND1 12388 P30999 Ctnnd1 mouse Y257 450397 APsRQDVyGPQPQVR X X +Src Src iso1 P05480-1 mouse EFNB1 13641 P52795 Efnb1 mouse Y323 448342 yEkVsGDyGHPVyIV X 3481 +Src Src iso1 P05480-1 mouse Pyk2 19229 Q9QVP9 Ptk2b mouse Y580 447957 yIEDEDyyKASVTRL PK_Tyr_Ser-Thr X +Src Src iso1 P05480-1 mouse MTSS1 211401 Q8R1S4 Mtss1 mouse Y398 473757 LPDYAHyyTIGPGMF X X +Cdk6 CDK6 F1MA87 rat PKLR iso2 24651 P12928-2 Pklr rat S113 31084572 ATESFATsPLSYRPV PK X +WNK3 WNK3 Q9BYP7 human WNK1 65125 Q9H4A3 WNK1 human S382 454105 kRAsFAKsVIGTPEF Pkinase X +WNK3 WNK3 Q9BYP7 human KCC3 9990 Q9UHW9 SLC12A6 human T991 4770536 SAYTYERtLMMEQRS SLC12 X +WNK3 WNK3 Q9BYP7 human NKCC2 25065 P55016 Slc12a1 rat T96 458227 TNTYYLQtFGHNtMD AA_permease_N X +WNK3 WNK3 Q9BYP7 human NCCT 54300 P55018 Slc12a3 rat T58 469617 LRtFGYNtIDVVPAY AA_permease_N X +WNK3 WNK3 Q9BYP7 human KCC3 9990 Q9UHW9 SLC12A6 human T1048 4770548 YQEKVHMtWTKDKYM SLC12 X +WNK3 WNK3 Q9BYP7 human KCC3 9990 Q9UHW9 SLC12A6 human S96 10787161 IEDLSQNsITGEHSQ X +WNK3 WNK3 Q9BYP7 human NKCC2 25065 P55016 Slc12a1 rat T101 458228 LQtFGHNtMDAVPKI AA_permease_N X +Tssk2 TSSK2 O54863 mouse TSKS 22116 O54887 Tsks mouse S281 2797600 GCSGPPGsPEEPPRQ TSKS X +RIPK2 RIPK2 O43353 human RIPK2 8767 O43353 RIPK2 human S181 22641182 sLsQsRsskSAPEGG PK_Tyr_Ser-Thr X +RIPK2 RIPK2 O43353 human RIPK2 8767 O43353 RIPK2 human S180 25752142 MsLsQsRsskSAPEG PK_Tyr_Ser-Thr X +RIPK2 RIPK2 O43353 human RIPK2 8767 O43353 RIPK2 human S174 7444668 LsKWRMMsLsQsRss PK_Tyr_Ser-Thr X +RIPK2 RIPK2 O43353 human RIPK2 8767 O43353 RIPK2 human S176 460844 KWRMMsLsQsRsskS PK_Tyr_Ser-Thr X X 14397 +RIPK2 RIPK2 O43353 human RIPK2 8767 O43353 RIPK2 human S178 4272808 RMMsLsQsRsskSAP PK_Tyr_Ser-Thr X +RIPK2 RIPK2 O43353 human RIPK2 8767 O43353 RIPK2 human Y474 4270705 DLIMKEDyELVSTkP CARD X X +EPHA6 EphA6 Q9UF33 human GLO1 2739 Q04760 GLO1 human Y136 463450 GIAVPDVysACkRFE Glyoxalase X +Prkaa2 AMPKA2 Q09137 rat ACC1 60581 P11497 Acaca rat S1215 449868 YGMTHVAsVSDVLLD ACC_central X +Prkaa2 AMPKA2 Q09137 rat NHE5 6553 Q14940 SLC9A5 human S851 34424903 SLAKAGRsRsEssAD X X +Prkaa2 AMPKA2 Q09137 rat PGC-1 alpha 19017 O70343 Ppargc1a mouse S538 486320 SLFDVSPsCSSFNSP X +Prkaa2 AMPKA2 Q09137 rat NHE5 6553 Q14940 SLC9A5 human S620 34424901 RRYKAsCsRHFISED X X +Prkaa2 AMPKA2 Q09137 rat ACC1 60581 P11497 Acaca rat S79 448292 FHMRSsMsGLHLVKQ X 3661; 11818; 42801 +Prkaa2 AMPKA2 Q09137 rat NHE5 6553 Q14940 SLC9A5 human S575 34424900 VTNLLREsGsGACLD X X +Prkaa2 AMPKA2 Q09137 rat NHE5 6553 Q14940 SLC9A5 human S618 34424907 PRRRYKAsCsRHFIS X X +Prkaa2 AMPKA2 Q09137 rat NHE5 6553 Q14940 SLC9A5 human S577 34424902 NLLREsGsGACLDLQ X X +Prkaa2 AMPKA2 Q09137 rat PGC-1 alpha 19017 O70343 Ppargc1a mouse T177 486319 NHTHRIRtNPAIVkT X +Prkaa2 AMPKA2 Q09137 rat NHE5 6553 Q14940 SLC9A5 human S856 34424905 GRsRsEssADLPQQQ X X +Prkaa2 AMPKA2 Q09137 rat ACC1 60581 P11497 Acaca rat S1200 448290 IPtLNRMsFASNLNH ACC_central X +Prkaa2 AMPKA2 Q09137 rat NHE5 6553 Q14940 SLC9A5 human S853 34424904 AKAGRsRsEssADLP X X +Prkaa2 AMPKA2 Q09137 rat NHE5 6553 Q14940 SLC9A5 human S855 34424906 AGRsRsEssADLPQQ X X +IGF1R IGF1R P08069 human IRS1 3667 P35568 IRS1 human Y989 451287 VPssRGDyMTMQMSC X +IGF1R IGF1R P08069 human PDK1 5170 O15530 PDPK1 human Y376 447695 DEDCyGNyDNLLSQF X X +IGF1R IGF1R P08069 human PTHR 5745 Q03431 PTH1R human Y494 28764913 ARsGsssySyGPMVS X +IGF1R IGF1R P08069 human IRS1 3667 P35568 IRS1 human Y632 447565 GRKGsGDyMPMsPKs X +IGF1R IGF1R P08069 human ANXA2 302 P07355 ANXA2 human Y24 449483 HstPPsAyGsVkAyt X +IGF1R IGF1R P08069 human PCNA 5111 P12004 PCNA human Y250 231166701 DMGHLkYyLAPkIED PCNA_C X X +IGF1R IGF1R P08069 human IRS1 3667 P35568 IRS1 human Y941 448700 EEtGtEEyMKMDLGP X +IGF1R IGF1R P08069 human IRS4 8471 O14654 IRS4 human Y921 456294 EADSSsDyVNMDFTk X +IGF1R IGF1R P08069 human IRS1 3667 P35568 IRS1 human Y662 450356 QRVDPNGyMMMsPsG X +IGF1R IGF1R P08069 human IRS1 3667 P35568 IRS1 human Y896 447556 EPKsPGEyVNIEFGS X 3070 +IGF1R IGF1R P08069 human ER-alpha 2099 P03372 ESR1 human Y219 12620700 sIQGHNDyMCPATNQ zf-C4 X X +IGF1R IGF1R P08069 human IGF1R 3480 P08069 IGF1R human Y1161 448386 FGMTRDIyEtDyyRk PK_Tyr_Ser-Thr X X 3021; 80732 +IGF1R IGF1R P08069 human IRS4 8471 O14654 IRS4 human Y828 456293 GQNDNsEyVPMLPGk X +IGF1R IGF1R P08069 human IRS1 3667 P35568 IRS1 human Y1179 451288 GLENGLNyIDLDLVk X +IGF1R IGF1R P08069 human PCNA 5111 P12004 PCNA human Y60 38486265 RSEGFDTyrCDRNLA PCNA_N X X +IGF1R IGF1R P08069 human IGF1R 3480 P08069 IGF1R human Y1281 450102 FREVsFyySEENKLP X +IGF1R IGF1R P08069 human SHPS1 140885 P78324 SIRPA human Y470 451114 AsEDtLtyADLDMVH X X +IGF1R IGF1R P08069 human PDK1 5170 O15530 PDPK1 human Y373 447694 sEDDEDCyGNyDNLL X X +IGF1R IGF1R P08069 human IGF1R 3480 P08069 IGF1R human S982 7493700 SVNPEyFsAADVYVP X +IGF1R IGF1R P08069 human IRS4 8471 O14654 IRS4 human Y847 1877150802 GLDkEVSyNWDPKDA X +IGF1R IGF1R P08069 human H3 8350 P68431 H3C1 human Y41 10897613 GVkkPHryrPGtVAL Histone X X +IGF1R IGF1R P08069 human IGF1R 3480 P08069 IGF1R human Y980 448390 yASVNPEyFsAADVY X 4568 +IGF1R IGF1R P08069 human PCNA 5111 P12004 PCNA human Y133 231166700 LGIPEQEysCVVkMP PCNA_C X X +IGF1R IGF1R P08069 human IRS4 8471 O14654 IRS4 human Y656 1877150800 SGGRFRLyFCVDrGA X +IGF1R IGF1R P08069 human IGF1R 3480 P08069 IGF1R human Y1165 448387 RDIyEtDyyRkGGkG PK_Tyr_Ser-Thr X X 3024; 3918; 2969 +IGF1R IGF1R P08069 human IRS1 3667 P35568 IRS1 human Y732 23116331 LLPCTGDyMNMSPVG X +IGF1R IGF1R P08069 human IGF1R 3480 P08069 IGF1R human Y1280 450101 GFREVsFyySEENKL X +IGF1R IGF1R P08069 human IGF1R 3480 P08069 IGF1R human Y1166 448388 DIyEtDyyRkGGkGL PK_Tyr_Ser-Thr X 3024; 3918; 2969 +IGF1R IGF1R P08069 human SHPS1 140885 P78324 SIRPA human Y496 451115 PEPSFsEyASVQVPR X X +Nme1 NME1 Q05982 rat ALDOC 24191 P09117 Aldoc rat D319 8075400 SAWRGQRdNAGAATE Glycolytic X +Tbk1 TBK1 Q9WUN2 mouse STAT3 20848 P42227 Stat3 mouse S727 448191 NtIDLPMsPRTLDSL X 9134; 9136; 34911; 94994; 49081; 58978; 87544; 71958; 50804 +Tbk1 TBK1 Q9WUN2 mouse STING 72512 Q3TBT3 Sting1 mouse S365 31064700 QEPRLLIsGMDQPLP X X 62912; 72971; 51865 +Tbk1 TBK1 Q9WUN2 mouse IRF3 54131 P70671 Irf3 mouse S388 449028 KTVDLHIsNSQPISL X 4947; 29047; 83611; 10327; 53539; 81093; 52270; 61166 +MAP3K10 MLK2 Q02779 human DYRK2 8445 Q92630 DYRK2 human T381 3303402 YEHQRVytyIQsRFY Pkinase X +MAP3K10 MLK2 Q02779 human E2A 6929 P15923 TCF3 human S379 3180968 AGAPGALsPsyDGGL X X +MAP3K10 MLK2 Q02779 human E2A 6929 P15923 TCF3 human T355 455166 NFsssPstPVGsPQG X X +MAP3K10 MLK2 Q02779 human E2A 6929 P15923 TCF3 human S359 465682 sPstPVGsPQGLAGt X X +MAP3K10 MLK2 Q02779 human E2A 6929 P15923 TCF3 human S341 10359100 KALASIYsPDHssNN X X +MAP3K10 MLK2 Q02779 human E2A 6929 P15923 TCF3 human S352 465681 ssNNFsssPstPVGs X X +MAP3K10 MLK2 Q02779 human DYRK2 8445 Q92630 DYRK2 human S449 3303401 sQKLLDAsKRAKNFV Pkinase X +DMPK DMPK1 Q09013 human SRF 6722 P11831 SRF human T159 449631 DNkLRRYtTFsKRkT SRF-TF X X +TGFBR2 TGFBR2 P37173 human TGFBR1 7046 P36897 TGFBR1 human T185 448248 kDLIyDMttsGsGsG TGF_beta_GS X +TGFBR2 TGFBR2 P37173 human USP2 9099 O75604 USP2 human S207 803501400 ENYGRKGsASQVPSQ X +TGFBR2 TGFBR2 P37173 human TGFBR2 7048 P37173 TGFBR2 human S213 452047 TRkLMEFsEHCAIIL X +TGFBR2 TGFBR2 P37173 human USP2 9099 O75604 USP2 human S225 803501401 SRVPEIIsPTYRPIG X +TGFBR2 TGFBR2 P37173 human TGFBR1 7046 P36897 TGFBR1 human S187 448245 LIyDMttsGsGsGLP TGF_beta_GS X +TGFBR2 TGFBR2 P37173 human ENG 2022 P17813 ENG human S634 465618 VAVAAPAssESSStN X +TGFBR2 TGFBR2 P37173 human TGFBR2 7048 P37173 TGFBR2 human Y259 2869604 KGRFAEVykAKLkQN PK_Tyr_Ser-Thr X +TGFBR2 TGFBR2 P37173 human TGFBR1 7046 P36897 TGFBR1 human S191 448247 MttsGsGsGLPLLVQ TGF_beta_GS X +TGFBR2 TGFBR2 P37173 human TGFBR2 7048 P37173 TGFBR2 human S416 452049 sVDDLANsGQVGTAR PK_Tyr_Ser-Thr X +TGFBR2 TGFBR2 P37173 human TGFBR2 7048 P37173 TGFBR2 human Y424 2869602 GQVGTARyMAPEVLE PK_Tyr_Ser-Thr X +TGFBR2 TGFBR2 P37173 human TGFBR2 7048 P37173 TGFBR2 human S409 452048 LRLDPTLsVDDLANs PK_Tyr_Ser-Thr X +TGFBR2 TGFBR2 P37173 human TGFBR1 7046 P36897 TGFBR1 human S189 448246 yDMttsGsGsGLPLL TGF_beta_GS X +TGFBR2 TGFBR2 P37173 human ENG 2022 P17813 ENG human S635 465619 AVAAPAssESSStNH X +TGFBR2 TGFBR2 P37173 human TGFBR2 7048 P37173 TGFBR2 human Y336 2869603 AKGNLQEyLTRHVIS PK_Tyr_Ser-Thr X +TGFBR2 TGFBR2 P37173 human TGFBR1 7046 P36897 TGFBR1 human T200 4325704 LPLLVQRtIARtIVL TGF_beta_GS X +TGFBR2 TGFBR2 P37173 human TGFBR1 7046 P36897 TGFBR1 human T186 448249 DLIyDMttsGsGsGL TGF_beta_GS X +Hipk2 HIPK2 Q9QZR5 mouse MECP2 4204 P51608 MECP2 human S80 452713 AVPEAsAsPKQRRsI X X +Hipk2 HIPK2 Q9QZR5 mouse HIPK2 15258 Q9QZR5 Hipk2 mouse Y361 449571 SKAVCStyLQsRYYR Pkinase X +Hipk2 HIPK2 Q9QZR5 mouse MECP2 17257 Q9Z2D6 Mecp2 mouse S80 452713 AVPEAsAsPKQRRsI X +LRRK1 LRRK1 Q38SD2 human NDEL1 81565 Q9GZM8 NDEL1 human S155 25746642 ERNAFLEsELDEKEs NUDE_C X X +LRRK1 LRRK1 Q38SD2 human Restin iso3 6249 P30622-2 CLIP1 human T36 36744506 VVAPVEKtISSEKAS X X +LRRK1 LRRK1 Q38SD2 human Restin iso3 6249 P30622-2 CLIP1 human S1225 36744507 ASAKSLHsVVQTLES X X +LRRK1 LRRK1 Q38SD2 human Restin iso3 6249 P30622-2 CLIP1 human T191 3189760 PISNLTKtASEsISN X X +LRRK1 LRRK1 Q38SD2 human Rab7 7879 P51149 RAB7A human S72 468547 AGQERFQsLGVAFYR Ras X X +LRRK1 LRRK1 Q38SD2 human Restin iso3 6249 P30622-2 CLIP1 human T13 36744504 PSGLKAPtKILKPGS X X +LRRK1 LRRK1 Q38SD2 human NDEL1 81565 Q9GZM8 NDEL1 human S166 27722642 EKEsLLVsVQRLKDE NUDE_C X +LRRK1 LRRK1 Q38SD2 human Restin iso3 6249 P30622-2 CLIP1 human S1318 3189736 DDLNNYDsDDQEKQS X X +LRRK1 LRRK1 Q38SD2 human Restin iso3 6249 P30622-2 CLIP1 human T1384 36744502 EMFGHWAtNCNDDET CLIP1_ZNF X X +LRRK1 LRRK1 Q38SD2 human Restin iso3 6249 P30622-2 CLIP1 human T1099 36744508 NKSKELLtVENQKME X X +LRRK1 LRRK1 Q38SD2 human NDEL1 81565 Q9GZM8 NDEL1 human S213 40722081 MDsAVQAsLsLPAtP NUDE_C X +LRRK1 LRRK1 Q38SD2 human Restin iso3 6249 P30622-2 CLIP1 human T459 36744505 KGDLEVAtVSEkSRI X X +LRRK1 LRRK1 Q38SD2 human NDEL1 81565 Q9GZM8 NDEL1 human S162 25746646 sELDEKEsLLVsVQR NUDE_C X +LRRK1 LRRK1 Q38SD2 human NDEL1 81565 Q9GZM8 NDEL1 human T132 478045 LERAKRAtIVsLEDF X +LRRK1 LRRK1 Q38SD2 human Rab7 19349 P51150 Rab7a mouse S72 468547 AGQERFQsLGVAFYR Ras X +LRRK1 LRRK1 Q38SD2 human Restin iso3 6249 P30622-2 CLIP1 human S1190 3639977 ASLQKsIsITSALLT X X +LRRK1 LRRK1 Q38SD2 human CDK5RAP2 55755 Q96SN8 CDK5RAP2 human T102 41694203 PTEHIYKtNIELKVE Cnn_1N X +LRRK1 LRRK1 Q38SD2 human CDK5RAP2 55755 Q96SN8 CDK5RAP2 human S140 41694200 SLAEAGGsEIQRVKE X +LRRK1 LRRK1 Q38SD2 human Restin iso3 6249 P30622-2 CLIP1 human S1188 5678035 EKASLQKsIsITSAL X X +LRRK1 LRRK1 Q38SD2 human Restin iso3 6249 P30622-2 CLIP1 human T27 36744509 STALKTPtAVVAPVE X X +LRRK1 LRRK1 Q38SD2 human NDEL1 81565 Q9GZM8 NDEL1 human S95 1880106500 AQSYKQVsVLEDDLS X +Mink1 MINK Q9JM52 mouse NLRP3 216799 Q8R4B8 Nlrp3 mouse S725 31904665 VNCCLTSsFCRGLFS X +CLK1 CLK1 P49759 human Abl 25 P00519 ABL1 human T735 450291 DTEWRSVtLPRDLQS X 2864 +CLK1 CLK1 P49759 human RBM17 84991 Q96I25 RBM17 human S222 3209223 EEQDRPRsPtGPsNs X X +CLK1 CLK1 P49759 human RBM17 84991 Q96I25 RBM17 human S288 27936103 DATEkDAsKKsDsNP X X +CLK1 CLK1 P49759 human PTP1B 5770 P18031 PTPN1 human S243 9921201 DKRkDPssVDIkKVL Y_phosphatase X +CLK1 CLK1 P49759 human snRNP 70 6625 P08621 SNRNP70 human S226 451900 yDERPGPsPLPHRDR X X +CLK1 CLK1 P49759 human RBM20 309544 E9PT37 Rbm20 rat S638 31086436 YGPERPRsRsPMsRs X X +CLK1 CLK1 P49759 human RBM17 84991 Q96I25 RBM17 human S204 476471 DsRPRsQsSKAAIPP X X +CLK1 CLK1 P49759 human RBM17 84991 Q96I25 RBM17 human S62 27936100 IDLkRGGsSDDrQIV X X +CLK1 CLK1 P49759 human PTP1B 5770 P18031 PTPN1 human S50 447811 RNRyRDVsPFDHsRI Y_phosphatase X +CLK1 CLK1 P49759 human RBM17 84991 Q96I25 RBM17 human S202 27936104 EEDsRPRsQsSKAAI X X +CLK1 CLK1 P49759 human RBM17 84991 Q96I25 RBM17 human S266 27459081 QGLSTALsVEKTSKr G-patch X X +CLK1 CLK1 P49759 human RBM17 84991 Q96I25 RBM17 human S291 27936102 EkDAsKKsDsNPLTE X X +CLK1 CLK1 P49759 human RBM17 84991 Q96I25 RBM17 human S48 27936101 kSQRTkQsTVLAPVI X X +CLK1 CLK1 P49759 human RBM20 309544 E9PT37 Rbm20 rat S640 31086439 PERPRsRsPMsRsLS X X +CLK1 CLK1 P49759 human PTP1B 5770 P18031 PTPN1 human S242 9921200 MDKRkDPssVDIkKV Y_phosphatase X +CLK1 CLK1 P49759 human Trap150 230753 Q569Z6 Thrap3 mouse S243 452511 RAsVsDLsPRERsPA THRAP3_BCLAF1 X +CLK1 CLK1 P49759 human STF-1 2516 Q13285 NR5A1 human S203 447603 EYPEPYAsPPQPGLP X +Pkn1 PKN1 Q63433 rat PKN1 29355 Q63433 Pkn1 rat S577 458294 PAGLPSTsCsLSSPT X +Pkn1 PKN1 Q63433 rat PKN1 29355 Q63433 Pkn1 rat T504 458293 FSKQQGQtFQRARQM X +Pkn1 PKN1 Q63433 rat PKN1 29355 Q63433 Pkn1 rat T64 452112 ENLRRATtDLGRSLA HR1 X +Pkn1 PKN1 Q63433 rat PKN1 29355 Q63433 Pkn1 rat S377 452113 GLYNRSGsLSGRSSL X +Pkn1 PKN1 Q63433 rat PKN1 29355 Q63433 Pkn1 rat S579 458295 GLPSTsCsLSSPTHE X +Pkn1 PKN1 Q63433 rat PKN1 29355 Q63433 Pkn1 rat S534 452114 PNAVATGsFSPNASP X +Pkn1 PKN1 Q63433 rat PKN1 29355 Q63433 Pkn1 rat T778 447835 GYGDRtStFCGTPEF Pkinase X 2611 +Pkn1 PKN1 Q63433 rat PPP1R14A 114004 Q99MC0 Ppp1r14a rat T38 449098 QKRHARVtVkYDRRE PP1_inhibitor X +Pkn1 PKN1 Q63433 rat PKN1 29355 Q63433 Pkn1 rat S612 458296 LCSPLRKsPLTLEDF X +BRSK2 BRSK2 Q8IWQ3 human Tau iso8 4137 P10636-8 MAPT human S262 447930 NVKskIGstENLkHQ Tubulin-binding X +BRSK2 BRSK2 Q8IWQ3 human AMPKA1 5562 Q13131 PRKAA1 human T183 448786 sDGEFLRtsCGsPNy Pkinase X 2535; 2531; 4188; 5256; 50081; 74281 +BRSK2 BRSK2 Q8IWQ3 human RhoGDI alpha 396 P52565 ARHGDIA human S174 452196 kGMLARGsYsIkSRF Rho_GDI X X +BRSK2 BRSK2 Q8IWQ3 human TSC2 7249 P49815 TSC2 human S1387 450212 QPLsKssssPELQtL X 5584; 23402 +BRSK2 BRSK2 Q8IWQ3 human Tau iso8 4137 P10636-8 MAPT human S356 449104 rVQskIGsLDNItHV Tubulin-binding X +BRSK2 BRSK2 Q8IWQ3 human CDK16 5127 Q00536 CDK16 human S12 453448 KKIKRQLsMtLRGGr X X +Fer Fer P70451 mouse PECAM-1 18613 Q08481 Pecam1 mouse Y702 448760 TRATETVysEIRKVD X +Fer Fer P70451 mouse STAT3 6774 P40763 STAT3 human Y705 448192 DPGsAAPyLktKFIC X X 4093; 9145; 4324; 9131; 9138; 4323; 4074; 4113; 48313; 20977; 25023; 8119; 52075; 52527; 73533; 61958; 73452; 16185; 74309 +Fer Fer P70451 mouse PECAM-1 18613 Q08481 Pecam1 mouse Y717 465455 PNLMENRysRTEGSL X +Fer Fer P70451 mouse PECAM-1 18613 Q08481 Pecam1 mouse Y679 448759 PQNMDVEyTEVEVSS X +Fer Fer P70451 mouse CTNNB1 12387 Q02248 Ctnnb1 mouse Y142 449044 AVVNLINyQDDAELA X +Fer Fer P70451 mouse Fer 14158 P70451 Fer mouse Y715 448461 RQEDGGVysSSGLKQ PK_Tyr_Ser-Thr X +Prkca PKCA P05696 rat INSR iso2 3643 P06213-2 INSR human T1363 450327 KKNGRILtLPRSNPS X +Prkca PKCA P05696 rat CAMK2A 25400 P11275 Camk2a rat T286 447797 sCMHRQEtVDCLkkF X 12716 +Prkca PKCA P05696 rat Tau iso8 4137 P10636-8 MAPT human T231 449079 KKVAVVRtPPKsPss X 20473; 71429 +Prkca PKCA P05696 rat GluR2 29627 P19491 Gria2 rat S697 10306402 KMWTYMRsAEPSVFV Lig_chan X +Prkca PKCA P05696 rat SNAP23 8773 O00161 SNAP23 human S23 9766096 ItDEsLEstRRILGL X +Prkca PKCA P05696 rat PLCB3 29322 Q99JE6 Plcb3 rat S1105 448448 LDRKRNNsISEAKTR PLC-beta_C X 2484 +Prkca PKCA P05696 rat GPM6A 306439 Q812E9 Gpm6a rat T10 11488702 ENMEEGQtQKGCFEC X +Prkca PKCA P05696 rat PCDHGA3 93711 Q91XY5 Pcdhga3 mouse S922 41590812 GNGNKKKsGKKEKK_ Cadherin_tail X +Prkca PKCA P05696 rat Tau iso2 4137 P10636-2 MAPT human S315 449082 PVVSGDTsPRHLsNV X 35834; 20194; 98523; 91600; 49562 +Prkca PKCA P05696 rat HES1 3280 Q14469 HES1 human S37 11424700 TAsEHRKssKPIMEK HLH X X +Prkca PKCA P05696 rat CFTR 1080 P13569 CFTR human S707 2907509 sILNPINsIRKFsIV CFTR_R X +Prkca PKCA P05696 rat RAF1 5894 P04049 RAF1 human S497 3082308 AtVksRWsGsQQVEQ PK_Tyr_Ser-Thr X +Prkca PKCA P05696 rat MARCKS 25603 P30009 Marcks rat S156 447787 KRFsFKKsFkLsGFs MARCKS X X 2741; 11992 +Prkca PKCA P05696 rat G-alpha 15 14676 P30678 Gna15 mouse S334 11380904 QDGGRKGsRARRFFA G-alpha X +Prkca PKCA P05696 rat desmin 395906 P02542 DES chicken S56 1868158501 TsAVPTLsTFRTTRV Filament_head X +Prkca PKCA P05696 rat H1C 513971 P02253 H1-2 cow S104 451806 KGTGASGsFKLNKKA Linker_histone X +Prkca PKCA P05696 rat H1R 3269 P35367 HRH1 human S398 450937 WKRLRsHsRQyVSGL 7tm_1 X +Prkca PKCA P05696 rat Tau iso6 4137 P10636-6 MAPT human S346 449082 PVVSGDTsPRHLSNV X 35834; 20194; 98523; 91600; 49562 +Prkca PKCA P05696 rat ANXA2 302 P07355 ANXA2 human S26 450879 tPPsAyGsVkAytNF X +Prkca PKCA P05696 rat GLP1R 25051 P32301 Glp1r rat S432 451367 LNIQRDssMKPLKCP X +Prkca PKCA P05696 rat desmin 395906 P02542 DES chicken S29 466347 sPVFPRAsFGSRGsG Filament_head X +Prkca PKCA P05696 rat Kv3.4 3749 Q03721 KCNC4 human S9 451076 ISSVCVssYRGRKsG Potassium_chann X +Prkca PKCA P05696 rat uPA 5328 P00749 PLAU human S158 451052 CADGKKPsSPPEELK X +Prkca PKCA P05696 rat HRas 15461 Q61411 Hras mouse S177 455374 kLNPPDEsGPGCMSC X +Prkca PKCA P05696 rat ATP1A1 24211 P06685 Atp1a1 rat S16 449086 KyEPAAVsEHGDkks X X 4020 +Prkca PKCA P05696 rat Kv2.2 117105 Q63099 Kcnb2 rat S481 15720997 ESANIKDsVDDNHLs Kv2channel X +Prkca PKCA P05696 rat CFTR 1080 P13569 CFTR human T682 2907505 APVSWTEtKKQsFKQ CFTR_R X +Prkca PKCA P05696 rat SNAP-25 25012 P60881 Snap25 rat T138 449875 GGFIRRVtNDARENE SNAP-25 X +Prkca PKCA P05696 rat uPA 5328 P00749 PLAU human S323 451053 TGFGKENsTDYLYPE Trypsin X +Prkca PKCA P05696 rat GBPI-1 54866 Q9NXH3 PPP1R14D human T58 450935 SRRPSRLtVKYDRGQ PP1_inhibitor X +Prkca PKCA P05696 rat PITPNA 29525 P16446 Pitpna rat S166 450933 EDPAkFKsIKTGRGP IP_trans X +Prkca PKCA P05696 rat Tau iso6 4137 P10636-6 MAPT human T173 449079 KKVAVVRtPPKsPSS X 20473; 71429 +Prkca PKCA P05696 rat GPM6A 306439 Q812E9 Gpm6a rat S267 456834 QELHDIHsTRSKERL X +Prkca PKCA P05696 rat CACNA1B 257648 Q02294 Cacna1b rat S896 455283 ERARPRRsHsKEAPG X +Prkca PKCA P05696 rat RKIP 29542 P31044 Pebp1 rat S153 448755 RGkFkVEsFRKKYHL PBP X X +Prkca PKCA P05696 rat Tau iso8 4137 P10636-8 MAPT human S396 449081 GAEIVyKsPVVsGDt X 9632 +Prkca PKCA P05696 rat syndecan-2 25615 P34900 Sdc2 rat S187 452068 DLGERKPssAAyQKA Syndecan X +Prkca PKCA P05696 rat MARCKS 25603 P30009 Marcks rat S163 451837 sFkLsGFsFkKSKKE MARCKS X 8722 +Prkca PKCA P05696 rat Tau iso8 4137 P10636-8 MAPT human S404 449082 PVVsGDtsPRHLsNV X 35834; 20194; 98523; 91600; 49562 +Prkca PKCA P05696 rat syndecan-2 25615 P34900 Sdc2 rat S188 452069 LGERKPssAAyQKAP Syndecan X +Prkca PKCA P05696 rat SNAP23 64630 O70377 Snap23 rat S160 4148814 ENLTQVGsILGNLKN X +Prkca PKCA P05696 rat ADCY6 25289 Q03343 Adcy6 rat S10 450817 LPVARSGsGRSSMsW X +Prkca PKCA P05696 rat Kv3.4 3749 Q03721 KCNC4 human S21 451078 KsGNKPPsKTCLKEE Potassium_chann X +Prkca PKCA P05696 rat GluR5 iso2 2897 P39086-2 GRIK1 human S885 457627 KsRTKGKsSFTSILT X +Prkca PKCA P05696 rat mGluR5 iso2 24418 P31424-2 Grm5 rat S901 4213805 QHLWQRLsVHINKKE X +Prkca PKCA P05696 rat NMDAR1 24408 P35439 Grin1 rat S897 448256 sFKRRRssKDtSTGG X +Prkca PKCA P05696 rat TNNI3 29248 P23693 Tnni3 rat S43 450690 AKKKSKIsAsRKLQL X +Prkca PKCA P05696 rat Cortactin 60465 NP_001385572 Cttn rat T145 41425400 GFEYQGktEKHASQK HS1_rep X +Prkca PKCA P05696 rat MARCKS 25603 P30009 Marcks rat S152 447786 KKKKKRFsFKKsFkL MARCKS X X 2741; 11992 +Prkca PKCA P05696 rat Tau iso5 4137 P10636-5 MAPT human T231 449079 KKVAVVRtPPKsPSS X 20473; 71429 +Prkca PKCA P05696 rat TNNI3 29248 P23693 Tnni3 rat S23 448423 PAPVRRRssANYRAY Troponin-I_N X 4004 +Prkca PKCA P05696 rat neurogranin 4900 Q92686 NRGN human S36 455913 AAAKIQAsFrGHMAR IQ X +Prkca PKCA P05696 rat PLD1 iso2 25096 P70496-2 Pld1 rat S561 448574 SRKFSKFsLYRQLHR X X +Prkca PKCA P05696 rat NMDAR2B 2904 Q13224 GRIN2B human S1323 455808 ALAPRSVsLKDKGRF NMDAR2_C X +Prkca PKCA P05696 rat Akt1 24185 P47196 Akt1 rat S473 447855 RPHFPQFsYSASGTA Pkinase_C X 9271; 3787; 4060; 4051; 5102; 4058; 2336; 2337; 4075; 4070; 5012; 4071; 92982; 5315; 9563; 9018; 12694; 52240; 11962; 15116; 88106; 26580; 68035; 31957; 23430; 20235 +Prkca PKCA P05696 rat PPP2R5D 21770 Q7TNL5 Ppp2r5d mouse S566 457390 KVLLRRKsELPQDVy X +Prkca PKCA P05696 rat GFAP 396562 F1RR02 GFAP pig S8 449618 MERRRVtsAARRsYV Filament_head X +Prkca PKCA P05696 rat MAT1A 25331 P13444 Mat1a rat T342 451384 TYGTSKKtERDELLE S-AdoMet_synt_C X +Prkca PKCA P05696 rat SNAP23 8773 O00161 SNAP23 human T24 11486600 tDEsLEstRRILGLA X +Prkca PKCA P05696 rat GIRK4 29713 P48548 Kcnj5 rat S191 450684 GCMFVKIsQPKKRAE IRK X +Prkca PKCA P05696 rat STXBP1 25558 P61765 Stxbp1 rat S306 448743 VSQEVTRsLkDFSSs Sec1 X +Prkca PKCA P05696 rat GABRG2 14406 P22723 Gabrg2 mouse S381 452033 NPLLRMFsFKAPTID Neur_chan_memb X +Prkca PKCA P05696 rat MARCKS 4082 P29966 MARCKS human S163 447787 KRFsFkKsFkLsGFs MARCKS X 2741; 11992 +Prkca PKCA P05696 rat GluR2 29627 P19491 Gria2 rat S863 455806 NPSSSQNsQNFATyk X X +Prkca PKCA P05696 rat ADD1 24170 Q63028 Add1 rat S724 449829 KKKFRTPsFLKKSKK X +Prkca PKCA P05696 rat GluR5 iso2 2897 P39086-2 GRIK1 human S879 457626 QKKIKKKsRTKGKsS X +Prkca PKCA P05696 rat Tau iso5 4137 P10636-5 MAPT human S365 449081 GAEIVYKsPVVsGDT X 9632 +Prkca PKCA P05696 rat Myf-6 25714 P19335 Myf6 rat S221 451240 SSLQRLssIVDSISS X +Prkca PKCA P05696 rat G-alpha 15 2769 P30679 GNA15 human S336 11380905 GsKKGARsRRLFSHY G-alpha X +Prkca PKCA P05696 rat HES1 3280 Q14469 HES1 human S38 3882731 AsEHRKssKPIMEKR HLH X X +Prkca PKCA P05696 rat RGS5 8490 O15539 RGS5 human S84 10773104 SFKSFLKsEFSEENL RGS X +Prkca PKCA P05696 rat p47phox 653361 P14598 NCF1 human S370 451730 PAVPPRPsADLILNR p47_phox_C X +Prkca PKCA P05696 rat SH3BP2 6452 P78314 SH3BP2 human S278 455470 PAtPRRMsDPPLStM X +Prkca PKCA P05696 rat DGKD 8527 Q16760 DGKD human S66 452137 MLTkQNNsFQRsKRR PH X X +Prkca PKCA P05696 rat DYN1 1759 Q05193 DNM1 human S795 447604 VPPARPGsRGPAPGP X +Prkca PKCA P05696 rat H2B 303175 D3ZNZ9 Hist3h2ba rat S14 449904 TPAPkkGskkAITkA Histone X 6959 +Prkca PKCA P05696 rat FSHR 25449 P20395 Fshr rat T469 451072 ITLERWHtItHAMQL 7tm_1 X +Prkca PKCA P05696 rat FSHR 25449 P20395 Fshr rat T471 451073 LERWHtItHAMQLEC 7tm_1 X +Prkca PKCA P05696 rat TRPC6 iso2 89823 Q99N77 Trpc6 rat S714 455910 VPFNLVPsPKSLLYL X +Prkca PKCA P05696 rat GluR2 29627 P19491 Gria2 rat S661 10306401 IESAEDLsKQTEIAY Lig_chan X +Prkca PKCA P05696 rat ANXA2 282689 P04272 ANXA2 cow S26 450879 TPPSAyGsVKAYTNF X +Prkca PKCA P05696 rat SNAP23 64630 O70377 Snap23 rat S95 455262 NRTKNFEsGKNYKAt SNAP-25 X +Prkca PKCA P05696 rat PSEN1 5663 P49768 PSEN1 human S346 450179 EWEAQRDsHLGPHRs Presenilin X +Prkca PKCA P05696 rat Myf-6 25714 P19335 Myf6 rat S220 451239 SSSLQRLssIVDSIS X +Prkca PKCA P05696 rat NMDAR1 24408 P35439 Grin1 rat S890 447737 ITSTLAssFKRRRss X +Prkca PKCA P05696 rat NMDAR2B 2904 Q13224 GRIN2B human S1303 450171 NKLRRQHsyDtFVDL NMDAR2_C X 20274; 71335 +Prkca PKCA P05696 rat eIF2-beta 100009285 P41035 EIF2S2 rabbit S13 454001 MIFDPTMsKKKKKKK X +Prkca PKCA P05696 rat HMGB1 3146 P09429 HMGB1 human S46 33673900 sEFskkCsERWktMs HMG_box_2 X +Prkca PKCA P05696 rat GAP43 29423 P07936 Gap43 rat S41 448719 AATkIQAsFRGHITR IQ X X +Prkca PKCA P05696 rat PODXL 192181 Q9WTQ2 Podxl rat S415 21514209 GCCHQRIsQRKDQQR CD34_antigen X +Prkca PKCA P05696 rat TRPV1 83810 O35433 Trpv1 rat S800 450017 VPLLRDAsTRDRHAT X +Prkca PKCA P05696 rat PAM 25508 P14925 Pam rat S937 450813 FASRKGYsRKGFDRV X +Prkca PKCA P05696 rat Tau iso2 4137 P10636-2 MAPT human S307 449081 GAEIVYKsPVVSGDT X 9632 +Prkca PKCA P05696 rat desmin 395906 P02542 DES chicken S38 466348 GSRGsGSsVTSRVYQ Filament_head X +Prkca PKCA P05696 rat PKCA 24680 P05696 Prkca rat S657 448597 QSDFEGFsYVNPQFV Pkinase_C X 9371 +Prkca PKCA P05696 rat CEACAM1 81613 P16573 Ceacam1 rat S503 448536 QQSKRPTsASSSPTE X +Prkca PKCA P05696 rat calponin 1 396522 P26932 CNN1 chicken T170 469593 IIGLQMGtNKFAsQQ Calponin X +Prkca PKCA P05696 rat DYN1 140694 P21575 Dnm1 rat S795 447604 VPPARPGsRGPAPGP X +Prkca PKCA P05696 rat IRS1 25467 P35570 Irs1 rat S612 447562 DDGyMPMsPGVAPVP X 3193; 2386; 3203 +Prkca PKCA P05696 rat NMDAR1 24408 P35439 Grin1 rat S896 448255 ssFKRRRssKDtSTG X X +Prkca PKCA P05696 rat ATP1A1 24211 P06685 Atp1a1 rat S23 449087 sEHGDkkskkAKKER X X 4006 +Prkca PKCA P05696 rat CFTR 1080 P13569 CFTR human T604 2907506 NKTRILVtsKMEHLK X +Prkca PKCA P05696 rat NMDAR2A 24409 Q00959 Grin2a rat S1416 455790 ASYCSRDsRGHSDVy NMDAR2_C X +Prkca PKCA P05696 rat Myf-6 25714 P19335 Myf6 rat T99 451225 TDRRKAAtLRERRRL HLH X +Prkca PKCA P05696 rat C/EBP-alpha 24252 P05554 Cebpa rat S248 449826 GLPGPGGsLKGLAGP X +Prkca PKCA P05696 rat SH3BP2 6452 P78314 SH3BP2 human S225 455469 sDMPRAHsFTsKGPG X +Prkca PKCA P05696 rat HER2 2064 P04626 ERBB2 human T686 451817 QQKIRKYtMRRLLQE X 88583 +Prkca PKCA P05696 rat Kv3.1 25327 P25122 Kcnc1 rat S503 464642 LEINRADsKLNGEVA X +Prkca PKCA P05696 rat INSR 24954 P15127 Insr rat T1376 450327 KKNGRVLtLPRSNPS X +Prkca PKCA P05696 rat Cortactin 60465 NP_001385572 Cttn rat S135 31881968 QMDRVDQsAVGFEYQ HS1_rep X +Prkca PKCA P05696 rat PLM 5348 O00168 FXYD1 human S83 451424 EEGtFRssIRRLstR X +Prkca PKCA P05696 rat TRPV1 83810 O35433 Trpv1 rat S502 450016 YFLQRRPsLKSLFVD Ion_trans X +Prkca PKCA P05696 rat Kv3.4 3749 Q03721 KCNC4 human S8 451075 MISSVCVssYRGRKs Potassium_chann X +Prkca PKCA P05696 rat NRF2 83619 O54968 Nfe2l2 rat S40 450082 SREVFDFsQRQKDYE X +Prkca PKCA P05696 rat MARCKS 4082 P29966 MARCKS human S167 466360 FkKsFkLsGFsFkKN MARCKS X 8722 +Prkca PKCA P05696 rat PITPNA 18738 P53810 Pitpna mouse S166 450933 EDPAkFKsVKTGRGP IP_trans X X +Prkca PKCA P05696 rat PLD1 iso2 25096 P70496-2 Pld1 rat S2 448572 ______MsLRSEARV X X +Prkca PKCA P05696 rat PLM 5348 O00168 FXYD1 human S88 451425 RssIRRLstRRR___ X +Prkca PKCA P05696 rat SNAP-25 25012 P60881 Snap25 rat S187 448668 RIMEkADsNkTRIDE X +Prkca PKCA P05696 rat PTPRA 19262 P18052 Ptpra mouse S204 447612 PLLARsPstNRKYPP X +Prkca PKCA P05696 rat RGS5 8490 O15539 RGS5 human S166 482845 HALMEKDsLPRFVRS RGS X +Prkca PKCA P05696 rat SNAP23 8773 O00161 SNAP23 human S161 4148814 ENLtQVGsILGNLKD X +Prkca PKCA P05696 rat PLM 58971 O08589 Fxyd1 rat S83 451424 EEGtFRSsIRRLstR X +Prkca PKCA P05696 rat GFAP 396562 F1RR02 GFAP pig S34 449621 LGPGPRLsLARMPPP Filament_head X +Prkca PKCA P05696 rat MOR-1 25601 P33535 Oprm1 rat T370 447785 sTRVRQNtREHPsTA X +Prkca PKCA P05696 rat PLM 58971 O08589 Fxyd1 rat S88 451425 RSsIRRLstRRR___ X +Prkca PKCA P05696 rat GABRG2 iso2 14406 P22723-2 Gabrg2 mouse S365 486436 FVSNRKPsKDKDKKK Neur_chan_memb X +Prkca PKCA P05696 rat GRK2 156 P25098 GRK2 human S29 447724 ATPAARAskkILLPE X +Prkca PKCA P05696 rat GJA1 24392 P08050 Gja1 rat S368 447813 QRPssRAssRAssRP X 3511; 52559 +Prkca PKCA P05696 rat SLC18A3 60422 Q62666 Slc18a3 rat S480 450965 GLLTRSRsERDVLLD X X +Prkca PKCA P05696 rat Kv3.4 3749 Q03721 KCNC4 human S15 451077 ssYRGRKsGNKPPsK Potassium_chann X +Prkca PKCA P05696 rat PITPNA 5306 Q00169 PITPNA human S165 450933 EDPAkFKsIKTGRGP IP_trans X +Prkca PKCA P05696 rat CNR1 25248 P20272 Cnr1 rat S317 450999 IQRGtQKsIIIHtSE 7tm_1 X +Prkca PKCA P05696 rat GJA1 24392 P08050 Gja1 rat S369 459208 RPssRAssRAssRPR X X +Prkca PKCA P05696 rat Tau iso5 4137 P10636-5 MAPT human S373 449082 PVVsGDTsPRHLSNV X 35834; 20194; 98523; 91600; 49562 +Prkca PKCA P05696 rat CFTR 1080 P13569 CFTR human S686 449980 WTEtKKQsFKQTGEF CFTR_R X X +Prkca PKCA P05696 rat GABRG2 29709 Q6PW52 Gabrg2 rat S381 452033 NPLLRMFsFKAPTID Neur_chan_memb X +Prkca PKCA P05696 rat ADD2 119 P35612 ADD2 human S713 449802 KKKFRtPsFLKKsKK X +Prkca PKCA P05696 rat HMGCR 25675 P51639 Hmgcr rat S871 448568 SHMVHNRsKINLQDL X +Prkca PKCA P05696 rat TREK-2 65272 Q9JIS4 Kcnk10 rat S359 465530 RETRRRLsVEIHDKL X +Prkca PKCA P05696 rat Cortactin 60465 NP_001385572 Cttn rat S172 15176497 QADRVDKsAVGFDYQ HS1_rep X +Prkca PKCA P05696 rat ADD1 118 P35611 ADD1 human S726 449829 KKKFRtPsFLKKsKK X +Prkca PKCA P05696 rat PMCA4 493 P23634 ATP2B4 human S1115 452025 NTFQTGAsFKGVLRR ATP_Ca_trans_C X +Prkca PKCA P05696 rat Tau iso6 4137 P10636-6 MAPT human S338 449081 GAEIVYKsPVVSGDT X 9632 +Prkca PKCA P05696 rat p40phox 4689 Q15080 NCF4 human T154 448266 LRRLRPRtRKVKSVs X 4311 +Prkca PKCA P05696 rat CACNA1B 257648 Q02294 Cacna1b rat S898 455281 ARPRRsHsKEAPGAD X +Prkca PKCA P05696 rat DGKD 8527 Q16760 DGKD human S70 452138 QNNsFQRsKRRYFKL PH X X +Prkca PKCA P05696 rat CD5 921 P06127 CD5 human T434 450129 MsFHRNHtAtVRsHA X +Prkca PKCA P05696 rat desmin 395906 P02542 DES chicken S12 466346 SsSQRVSsYRRTFGG Filament_head X +Prkca PKCA P05696 rat SNAP23 64630 O70377 Snap23 rat S120 455263 NVVsKQPsRITNGQP SNAP-25 X +Prkca PKCA P05696 rat HSPB8 26353 Q9UJY1 HSPB8 human S14 7994901 PFSCHYPsRLRRDPF X +Prkca PKCA P05696 rat GIRK1 50599 P63251 Kcnj3 rat S185 450683 GCMFIKMsQPKKRAE IRK X +Prkca PKCA P05696 rat PTPRA 19262 P18052 Ptpra mouse S180 447611 QAGsHSNsFRLSNGR X +Prkca PKCA P05696 rat Tau iso6 4137 P10636-6 MAPT human S177 449080 VVRtPPKsPSSAKSR X 20473 +Prkca PKCA P05696 rat PITPNA 29525 P16446 Pitpna rat T59 1305700 DGEKGQYtHKIYHLQ IP_trans X +Prkca PKCA P05696 rat TNNI3 29248 P23693 Tnni3 rat S24 448424 APVRRRssANYRAYA Troponin-I_N X 4004 +Prkca PKCA P05696 rat STXBP1 25558 P61765 Stxbp1 rat S313 448744 sLkDFSSsKRMNTGE Sec1 X X +Prkca PKCA P05696 rat Kir6.2 16514 Q61743 Kcnj11 mouse T180 450652 QAHRRAEtLIFSKHA X +Prkca PKCA P05696 rat VASP 361517 B5DEX4 Vasp rat S154 448379 EHLERRVsNAGGPPA X X 3111; 84519 +Prkca PKCA P05696 rat ATP2B2 491 Q01814 ATP2B2 human T1139 11422300 RGLNRIQtQIRVVKA ATP_Ca_trans_C X +Prkca PKCA P05696 rat mGluR1 24414 P23385 Grm1 rat T695 453089 GSKKKICtRKPRFMS 7tm_3 X +Prkca PKCA P05696 rat POLB 29240 P06766 Polb rat S44 41521700 NAYRKAAsVIAKyPH HHH_8 X +Prkca PKCA P05696 rat PLD1 iso2 25096 P70496-2 Pld1 rat T147 448573 PIPTKRHtFRRQNVK PX X X +Prkca PKCA P05696 rat RAF1 5894 P04049 RAF1 human S619 5822317 sLPKINRsAsEPsLH X +Prkca PKCA P05696 rat GFAP 396562 F1RR02 GFAP pig S13 449619 VtsAARRsYVSSLET Filament_head X +Prkca PKCA P05696 rat TREK-2 65272 Q9JIS4 Kcnk10 rat S326 465529 GDWLRVLsKKTKEEV X +Prkca PKCA P05696 rat GABRG2 14406 P22723 Gabrg2 mouse S365 486436 FVSNRkPskDkDkkk Neur_chan_memb X +Prkca PKCA P05696 rat G-gamma 12 14701 Q9DAS9 Gng12 mouse S2 447876 ______MssktAstN X +Prkca PKCA P05696 rat calcyon 192349 P58821 Caly rat S169 25687501 MPAIWGNsYRAGKEE Calcyon X +Prkca PKCA P05696 rat CFTR 1080 P13569 CFTR human S790 2907510 IHRKTTAsTRKVsLA CFTR_R X +Prkca PKCA P05696 rat HSPB8 26353 Q9UJY1 HSPB8 human T63 7994900 LsSAWPGtLRSGMVP X +Prkca PKCA P05696 rat PTGIR 5739 P43119 PTGIR human S328 450985 TPLSQLAsGRRDPRA X X +Prkca PKCA P05696 rat GLP1R 25051 P32301 Glp1r rat S431 451366 RLNIQRDssMKPLKC X +Prkca PKCA P05696 rat APP 54226 P08592 App rat S730 448200 LKKKQYtsIHHGVVE APP_amyloid X +Prkca PKCA P05696 rat Tau iso5 4137 P10636-5 MAPT human S235 449080 VVRtPPKsPSSAKSR X 20473 +Prkca PKCA P05696 rat CD5 921 P06127 CD5 human T436 450130 FHRNHtAtVRsHAEN X +Prkca PKCA P05696 rat PFKFB2 287019 P26285 PFKFB2 cow T476 465673 TPLSSSNtIRRPRNY X +Prkca PKCA P05696 rat ADD3 25230 Q62847 Add3 rat S692 452158 KKKFRTPsFLKKNKK X +Prkca PKCA P05696 rat TNNI3 29248 P23693 Tnni3 rat S45 450691 KKSKIsAsRKLQLkT X +Prkca PKCA P05696 rat SNAP23 8773 O00161 SNAP23 human S95 455262 NRTkNFEsGkAykTt SNAP-25 X +Prkca PKCA P05696 rat ADD1 118 P35611 ADD1 human S716 449828 GsPGKsPsKKKKKFR X +Prkca PKCA P05696 rat CFTR 1080 P13569 CFTR human S641 2907508 QNLQPDFsSKLMGCD CFTR_R X +Prkca PKCA P05696 rat p47phox 653361 P14598 NCF1 human S359 451729 EERQtQRsKPQPAVP p47_phox_C X +Prkca PKCA P05696 rat myogenin 17928 P12979 Myog mouse T87 451161 VDRRRAAtLREKRRL HLH X +Prkca PKCA P05696 rat Tau iso8 4137 P10636-8 MAPT human S235 449080 VVRtPPKsPssAKsR X 20473 +Prkca PKCA P05696 rat PITPNA 5306 Q00169 PITPNA human T58 1305700 DGEkGQytHkIYHLQ IP_trans X +Prkca PKCA P05696 rat C/EBP-beta 24253 P21272 Cebpb rat S240 452156 NNIAVRKsRDKAKMR bZIP_2 X +Prkca PKCA P05696 rat GABRB1 25450 P15431 Gabrb1 rat S434 450244 GRIRRRAsQLKVKIP Neur_chan_memb X +Prkca PKCA P05696 rat RNF10 50849 Q3UIW5 Rnf10 mouse S31 1868450200 SSASSGSsKGQQPPR X +Prkca PKCA P05696 rat GJA1 24392 P08050 Gja1 rat S262 450694 sPskDCGsPkyAyFN X +Prkca PKCA P05696 rat ADD2 119 P35612 ADD2 human S703 451693 GsPsKsPsKKKKKFR X +Prkca PKCA P05696 rat GluR2 29627 P19491 Gria2 rat S880 448351 yNVyGIEsVkI____ X X +Prkca PKCA P05696 rat CACNA1B 257648 Q02294 Cacna1b rat S802 469610 EERLRYAsTRHVRPD X +Prkca PKCA P05696 rat POLB 29240 P06766 Polb rat S55 41521701 KyPHKIKsGAEAKKL HHH_8 X +Prkca PKCA P05696 rat SYT1 25716 P21707 Syt1 rat T112 448549 DVKDLGKtMKDQALK X X +Prkca PKCA P05696 rat Kv2.2 117105 Q63099 Kcnb2 rat S488 15721000 sVDDNHLsPSRWKWA Kv2channel X +Rps6ka5 MSK1 Q8C050 mouse ataxin-1 20238 P54254 Atxn1 mouse S751 449110 ATRKRRWsAPETRKL X X +Rps6ka5 MSK1 Q8C050 mouse H3 360198 P68433 H3c1 mouse S10 455676 tkQTARkstGGkAPr Histone X X 9701; 9711; 9606; 3465; 3642; 3377; 3475; 3458; 5764; 47398; 8481; 8552; 53348; 29237; 66065; 43185; 64522; 52725 +Rps6ka5 MSK1 Q8C050 mouse BAD 12015 Q61337 Bad mouse S112 447860 ETRsRHssyPAGtEE Bcl-2_BAD X X 9291; 5284; 9296; 5193; 11865; 94223 +Rps6ka5 MSK1 Q8C050 mouse LKB1 20869 Q9WTK7 Stk11 mouse S431 448147 sNKIRRLsACKQQ__ X 3482 +Rps6ka5 MSK1 Q8C050 mouse STAT3 20848 P42227 Stat3 mouse S727 448191 NtIDLPMsPRTLDSL X X 9134; 9136; 34911; 94994; 49081; 58978; 87544; 71958; 50804 +Rps6ka5 MSK1 Q8C050 mouse HMGN1 15312 P18608 Hmgn1 mouse S20 454111 kAEPKRRsARLsAkP HMG14_17 X +Rps6ka5 MSK1 Q8C050 mouse NFkB-p65 19697 Q04207 Rela mouse S276 447798 SMQLRRPsDRELSEP RHD_dimer X +Rps6ka5 MSK1 Q8C050 mouse H3 iso3 15081 P84244 H3f3b mouse S10 455676 tKQTARksTGGkAPR Histone X 9701; 9711; 9706; 3465; 3642; 3377; 3475; 3458; 5764; 47398; 8481; 8552; 53348; 29237; 66065; 43185; 64522; 52725 +Rps6ka5 MSK1 Q8C050 mouse H3 360198 P68433 H3c1 mouse S28 455677 ATkAArksAPATGGV Histone X X 9713 +Rps6ka5 MSK1 Q8C050 mouse PLA2G4A 18783 P47713 Pla2g4a mouse S726 447599 RQNPsRCsVsLsNVE X +Rps6ka5 MSK1 Q8C050 mouse HMGN1 15312 P18608 Hmgn1 mouse S7 465531 _MPKRKVsADGAAkA HMG14_17 X +Rps6ka5 MSK1 Q8C050 mouse HMGN1 15312 P18608 Hmgn1 mouse S24 454112 KRRsARLsAkPAPAk HMG14_17 X +CDK10 CDK10 Q15131 human Ets-2 2114 P15036 ETS2 human S220 30320500 PKGGLLDsMCPAstP X +CDK10 CDK10 Q15131 human Ets-2 2114 P15036 ETS2 human S225 30320501 LDsMCPAstPsVLSS X +PRKDC DNAPK P78527 human Oct1 5451 P14859 POU2F1 human S92 483941 sQPsQQPsVQAAIPQ X +PRKDC DNAPK P78527 human hnRNP P2 2521 P35637 FUS human T19 179463707 QSYGAYPtQPGQGYs X +PRKDC DNAPK P78527 human Artemis 64421 Q96SD1 DCLRE1C human S503 466574 NDEITDEsLENFPSS X +PRKDC DNAPK P78527 human MCC 4163 P23508 MCC human S120 3624826 LRsELsQsQHEVNED X +PRKDC DNAPK P78527 human Oct4 5460 Q01860 POU5F1 human S93 25236708 PQGGLEtsQPEGEAG X X +PRKDC DNAPK P78527 human IRF3 3661 Q14653 IRF3 human T135 477901 GGGSTSDtQEDILDE X X +PRKDC DNAPK P78527 human Oct1 5451 P14859 POU2F1 human T226 483948 LQAQNLLtQLPQQsQ X +PRKDC DNAPK P78527 human XRCC4 7518 Q13426 XRCC4 human S327 3195416 sLEtLRNssPEDLFD XRCC4 X +PRKDC DNAPK P78527 human WRN 7486 Q14191 WRN human S319 14823400 SNNLNLLsFEDSTTG X +PRKDC DNAPK P78527 human XRCC4 7518 Q13426 XRCC4 human S304 3238501 ENsRPDSsLPETSKK XRCC4 X +PRKDC DNAPK P78527 human p53 7157 P04637 TP53 human S37 447532 NVLsPLPsQAMDDLM TAD2 X 9289 +PRKDC DNAPK P78527 human POLL 27343 Q9UGP5 POLL human T204 62925702 EASDGEEtQVSAADL X +PRKDC DNAPK P78527 human XPA 7507 P23025 XPA human S196 460698 RSLEVWGsQEALEEA X +PRKDC DNAPK P78527 human hnRNP P2 2521 P35637 FUS human S42 3306333 QQSYSGYsQSTDTSG X +PRKDC DNAPK P78527 human Oct1 5451 P14859 POU2F1 human S78 483937 QSKSNEEsGDsQQPs X +PRKDC DNAPK P78527 human IGFBP3 3486 P17936 IGFBP3 human S183 471397 KKGHAKDsQRYKVDy X +PRKDC DNAPK P78527 human WRN 7486 Q14191 WRN human S440 3196118 DTsYVIEsDEDLEME X X +PRKDC DNAPK P78527 human HSP90A 3320 P07900 HSP90AA1 human T7 448320 _MPEEtQtQDQPMEE X 3488 +PRKDC DNAPK P78527 human Ku80 7520 P13010 XRCC5 human S580 452072 GAHFsVSsLAEGsVT X +PRKDC DNAPK P78527 human H2AX 3014 P16104 H2AX human T136 455687 PsGGkkAtQAsQEy_ X X +PRKDC DNAPK P78527 human Oct1 5451 P14859 POU2F1 human T100 483942 VQAAIPQtQLMLAGG X +PRKDC DNAPK P78527 human hnRNP U 3192 Q00839 HNRNPU human S59 468001 AMEPGNGsLDLGGDs X X +PRKDC DNAPK P78527 human RFA2 6118 P15927 RPA2 human S29 448338 QsPGGFGsPAPsQAE X +PRKDC DNAPK P78527 human p53 7157 P04637 TP53 human S9 447538 EEPQsDPsVEPPLsQ P53_TAD X 9288 +PRKDC DNAPK P78527 human fumarase 2271 P07954 FH human T236 49156200 IkIGRTHtQDAVPLT Lyase_1 X X +PRKDC DNAPK P78527 human Pnk1 11284 Q96T60 PNKP human S114 460832 EEtRtPEsQPDtPPG X 3522 +PRKDC DNAPK P78527 human Oct1 5451 P14859 POU2F1 human T162 483946 ASAATPMtQIPLsQP X +PRKDC DNAPK P78527 human p53 7157 P04637 TP53 human S46 447536 AMDDLMLsPDDIEQW TAD2 X 2521 +PRKDC DNAPK P78527 human HOXA11 3207 P31270 HOXA11 human T119 55571506 ANVYHHPtPAVSSNF DUF3528 X +PRKDC DNAPK P78527 human SRF 6722 P11831 SRF human S446 449956 STMQVSHsQVQEPGG X +PRKDC DNAPK P78527 human p53 7157 P04637 TP53 human T18 447541 EPPLsQEtFsDLWkL P53_TAD X 2529 +PRKDC DNAPK P78527 human Akt1 207 P31749 AKT1 human S473 447855 RPHFPQFsysAsGtA Pkinase_C X X 9271; 3787; 4060; 4051; 5102; 4058; 2336; 2337; 4075; 4070; 5012; 4071; 92982; 5315; 9563; 9018; 12694; 52240; 11962; 15116; 88106; 26580; 68035; 31957; 23430; 20235 +PRKDC DNAPK P78527 human Ku70 2547 P12956 XRCC6 human S6 452070 __MsGWEsyykTEGD X +PRKDC DNAPK P78527 human SOX2 6657 P48431 SOX2 human S251 6738002 VksEAsssPPVVtSS X X 92186 +PRKDC DNAPK P78527 human hnRNP P2 2521 P35637 FUS human S131 3306337 QPQSGSYsQQPSYGG X +PRKDC DNAPK P78527 human Sin1 79109 Q9BPZ7 MAPKAP1 human S186 27458520 VYLPLHssQDRLLPM CRIM X X +PRKDC DNAPK P78527 human hnRNP P2 2521 P35637 FUS human S30 179463702 QGYsQQSsQPYGQQS X X +PRKDC DNAPK P78527 human FOXA2 P32182 Foxa2 rat S283 8046508 TAPGTQAsQVQLGEA X +PRKDC DNAPK P78527 human Artemis 64421 Q96SD1 DCLRE1C human S553 460664 QGsQGWDsQSDTVLL X +PRKDC DNAPK P78527 human GOLPH3 64083 Q9H4A6 GOLPH3 human T148 31834910 KEtQPPEtVQNWIEL GPP34 X X +PRKDC DNAPK P78527 human WRN 7486 Q14191 WRN human S467 3196124 DTsYVIEsDEDLEME X X +PRKDC DNAPK P78527 human hnRNP P2 2521 P35637 FUS human T68 179463704 sQNTGYGtQSTPQGY X +PRKDC DNAPK P78527 human NHEJ1 79840 Q9H9Q4 NHEJ1 human S55 4084907 QVDTSVVsQRAKELN XLF X +PRKDC DNAPK P78527 human Oct1 5451 P14859 POU2F1 human S167 483947 PMtQIPLsQPIQIAQ X +PRKDC DNAPK P78527 human SRF 6722 P11831 SRF human S435 449955 LTVLNAFsQAPSTMQ X +PRKDC DNAPK P78527 human Artemis 64421 Q96SD1 DCLRE1C human S645 457531 NLSTNADsQsssDFE X X +PRKDC DNAPK P78527 human RFA2 6118 P15927 RPA2 human S4 470082 ____MWNsGFEsyGs X +PRKDC DNAPK P78527 human EGR1 1958 P18146 EGR1 human S301 11423702 AFATQSGsQDLKALN X X +PRKDC DNAPK P78527 human IKKG 8517 Q9Y6K9 IKBKG human S43 449037 PAMLHLPsEQGAPEt X X +PRKDC DNAPK P78527 human Oct1 5451 P14859 POU2F1 human S85 483939 sGDsQQPsQPsQQPs X +PRKDC DNAPK P78527 human OBFC2B 79035 Q9BQ15 NABP2 human S134 25302960 NDSNPSAsQPTTGPS X X +PRKDC DNAPK P78527 human hnRNP U iso2 3192 Q00839-2 HNRNPU human S59 468001 AMEPGNGsLDLGGDS X +PRKDC DNAPK P78527 human LIG4 3981 P49917 LIG4 human T650 454069 HLkAPNLtNVNKISN X +PRKDC DNAPK P78527 human Vimentin 7431 P08670 VIM human S459 470128 GQVINEtsQHHDDLE X +PRKDC DNAPK P78527 human DNAPK 5591 P78527 PRKDC human T3950 473573 GHAFGSAtQFLPVPE PI3_PI4_kinase X X +PRKDC DNAPK P78527 human Sin1 79109 Q9BPZ7 MAPKAP1 human S367 56676494 DGVFEEDsQIDIATV X X +PRKDC DNAPK P78527 human Ku80 7520 P13010 XRCC5 human S577 452071 EQGGAHFsVSsLAEG X +PRKDC DNAPK P78527 human Oct1 5451 P14859 POU2F1 human S81 483938 SNEEsGDsQQPsQPs X +PRKDC DNAPK P78527 human XRCC1 7515 P18887 XRCC1 human S371 458811 FANtPKysQVLGLGG BRCT X +PRKDC DNAPK P78527 human PELP1 27043 Q8IZL8 PELP1 human S1033 472322 LAPEALPsQGEVERE X +PRKDC DNAPK P78527 human Vimentin 7431 P08670 VIM human S430 470126 LREtNLDsLPLVDtH X +PRKDC DNAPK P78527 human Oct1 5451 P14859 POU2F1 human S232 483949 LtQLPQQsQANLLQS X +PRKDC DNAPK P78527 human hnRNP P2 2521 P35637 FUS human T11 179463706 NDYtQQAtQSYGAYP X +PRKDC DNAPK P78527 human p53 22059 P02340 Tp53 mouse S7 448716 _MTAMEEsQsDIsLE X +PRKDC DNAPK P78527 human XRCC4 7518 Q13426 XRCC4 human S320 475981 HISAENMsLEtLRNs XRCC4 X X +PRKDC DNAPK P78527 human RAG2 5897 P55895 RAG2 human S365 482844 EQTTFTNsQTSTEDP RAG2 X +PRKDC DNAPK P78527 human Ku70 2547 P12956 XRCC6 human S51 10211800 AsKAMFEsQsEDELT Ku_N X +PRKDC DNAPK P78527 human Ku80 7520 P13010 XRCC5 human T715 452073 KDkPsGDtAAVFEEG X +PRKDC DNAPK P78527 human PDX1 3651 P52945 PDX1 human T11 456815 EEQYYAAtQLYKDPC X +PRKDC DNAPK P78527 human USF1 22278 Q61069 Usf1 mouse S262 7367003 RQSNHRLsEELQGLD X X +PRKDC DNAPK P78527 human DNAPK 5591 P78527 PRKDC human T2638 448712 VAGQIRAtQQQHDFt DNAPKcs_CC5 X +PRKDC DNAPK P78527 human GR 24413 P06536 Nr3c1 rat S527 452135 QQATAGVsQDTSENP X +PRKDC DNAPK P78527 human TOP1 7150 P11387 TOP1 human S10 465604 GDHLHNDsQIEADFR X +PRKDC DNAPK P78527 human p53 22059 P02340 Tp53 mouse S18 447490 IsLELPLsQEtFsGL P53_TAD X 9284; 9286; 12571; 56979 +PRKDC DNAPK P78527 human DNAPK 5591 P78527 PRKDC human T2609 448710 LtPMFVEtQAsQGtL DNAPKcs_CC5 X X +PRKDC DNAPK P78527 human Oct1 5451 P14859 POU2F1 human S147 483945 HsAsQQHsAAGATIS X +PRKDC DNAPK P78527 human hnRNP P2 2521 P35637 FUS human S54 283458502 TSGYGQSsYSSYGQs X +PRKDC DNAPK P78527 human Ku70 2547 P12956 XRCC6 human S27 449267 QEENLEAsGDykYsG X +PRKDC DNAPK P78527 human FIS1 66437 Q9CQ92 Fis1 mouse T34 1876807204 AGsVSKStQFEYAWC Fis1_TPR_N X +PRKDC DNAPK P78527 human Sin1 79109 Q9BPZ7 MAPKAP1 human S343 1876127002 DLDSTLEsQSAWEFC X X +PRKDC DNAPK P78527 human Pnk1 11284 Q96T60 PNKP human S126 460833 PPGtPLVsQDEKRDA X X +PRKDC DNAPK P78527 human hnRNP P2 2521 P35637 FUS human S142 283458501 SYGGQQQsYGQQQSY X +PRKDC DNAPK P78527 human Artemis 64421 Q96SD1 DCLRE1C human S516 460660 SSTVAGGsQsPKLFS X X +PRKDC DNAPK P78527 human NHEJ1 79840 Q9H9Q4 NHEJ1 human T266 4084902 QLVssAPtLsAPEKE X +PRKDC DNAPK P78527 human H1C 3006 P16403 H1-2 human T146 9765189 KkAAGGAtPkKSAKK X X +PRKDC DNAPK P78527 human PGC-1 alpha 10891 Q9UBK2 PPARGC1A human S636 15422179 SRRPRyDsYEEYQHE X +PRKDC DNAPK P78527 human p27Kip1 1027 P46527 CDKN1B human S140 481797 PkTDPSDsQTGLAEQ X +PRKDC DNAPK P78527 human XPA 7507 P23025 XPA human S173 460697 VKkNPHHsQWGDMKL XPA_C X +PRKDC DNAPK P78527 human Oct4 5460 Q01860 POU5F1 human S111 25236703 EsNsDGAsPEPCtVt X +PRKDC DNAPK P78527 human NFkB-p105 4790 P19838 NFKB1 human S20 18751700 QMFHLDPsLTHTIFN X +PRKDC DNAPK P78527 human DNAPK 5591 P78527 PRKDC human T2647 448713 QQHDFtLtQTADGRs DNAPKcs_CC5 X X +PRKDC DNAPK P78527 human Artemis 64421 Q96SD1 DCLRE1C human S548 460663 THITEQGsQGWDsQS X +PRKDC DNAPK P78527 human MCC 4163 P23508 MCC human S118 3624820 SELRsELsQsQHEVN X +PRKDC DNAPK P78527 human DNAPK 5591 P78527 PRKDC human S2612 448711 MFVEtQAsQGtLQtR DNAPKcs_CC5 X +PRKDC DNAPK P78527 human YB-1 4904 P67809 YBX1 human T89 36130583 EDVFVHQtAIkkNNP CSD X X +PRKDC DNAPK P78527 human POLR2A 5430 P24928 POLR2A human S1616 450204 TPQSPSysPtsPsYS RNA_pol_Rpb1_R X 4735; 13499; 13546; 31262 +PRKDC DNAPK P78527 human MED1 5469 Q15648 MED1 human T1457 449866 HsKsPAytPQNLDsE X +PRKDC DNAPK P78527 human RFA2 6118 P15927 RPA2 human S8 470083 MWNsGFEsyGsssyG X 83745; 54762; 31912; 47711 +PRKDC DNAPK P78527 human ASF1A 25842 Q9Y294 ASF1A human S192 12671900 GWSTSENsLNVMLES X +PRKDC DNAPK P78527 human HSP90A 3320 P07900 HSP90AA1 human T5 448319 ___MPEEtQtQDQPM X 3488 +PRKDC DNAPK P78527 human hnRNP P2 2521 P35637 FUS human S84 3306336 STGGYGSsQSsQSSY X +PRKDC DNAPK P78527 human AIRE 326 O43918 AIRE human T68 1191300 ALLSWLLtQDSTAIL HSR X +PRKDC DNAPK P78527 human p53 24842 P10361 Tp53 rat S15 447490 MsIELPLsQEtFsCL P53_TAD X 9284; 9286; 12571; 56979 +PRKDC DNAPK P78527 human HOXA11 3207 P31270 HOXA11 human S98 55571505 RDCLQAPsAAGVPGD DUF3528 X +PRKDC DNAPK P78527 human RFA2 6118 P15927 RPA2 human S33 448339 GFGsPAPsQAEkkSR X 10148 +PRKDC DNAPK P78527 human p53 7157 P04637 TP53 human S20 447529 PLsQEtFsDLWkLLP P53_TAD X 9287 +PRKDC DNAPK P78527 human hnRNP P2 2521 P35637 FUS human S117 179463708 SGsYGSSsQSSSYGQ X +PRKDC DNAPK P78527 human AIRE 326 O43918 AIRE human S156 1191301 RGTASPGsQLKAKPP X +PRKDC DNAPK P78527 human AMPKG1 5571 P54619 PRKAG1 human T284 1827354810 LKCYLHEtLETIINR CBS X X +PRKDC DNAPK P78527 human RFA2 6118 P15927 RPA2 human S23 448337 GAGGYtQsPGGFGsP X +PRKDC DNAPK P78527 human NHEJ1 79840 Q9H9Q4 NHEJ1 human S263 4084903 QPEQLVssAPtLsAP X +PRKDC DNAPK P78527 human hnRNP P2 2521 P35637 FUS human S61 3306334 sYSSYGQsQNTGYGt X +PRKDC DNAPK P78527 human hnRNP P2 2521 P35637 FUS human S26 3306335 tQPGQGYsQQSsQPY X X +PRKDC DNAPK P78527 human GOLPH3 64083 Q9H4A6 GOLPH3 human T143 31834909 ALkHVKEtQPPEtVQ GPP34 X X +PRKDC DNAPK P78527 human Artemis 64421 Q96SD1 DCLRE1C human S538 460662 HISsQNSsQSTHITE X +PRKDC DNAPK P78527 human XRCC4 7518 Q13426 XRCC4 human S260 475982 KDDsIIssLDVtDIA XRCC4 X X +PRKDC DNAPK P78527 human Oct1 5451 P14859 POU2F1 human S141 483943 AAAVQQHsAsQQHsA X +PRKDC DNAPK P78527 human XRCC4 7518 Q13426 XRCC4 human S328 3195419 LEtLRNssPEDLFDE XRCC4 X +PRKDC DNAPK P78527 human DNAPK 5591 P78527 PRKDC human S3205 452351 tPLPEDNsMNVDQDG FAT X +PRKDC DNAPK P78527 human POLR2A 5430 P24928 POLR2A human S1621 3439802 SysPtsPsYSPTSPS RNA_pol_Rpb1_R X 13780 +PRKDC DNAPK P78527 human TIF1B 10155 Q13263 TRIM28 human S824 460839 LPGAGLssQELsGGP X 4127 +PRKDC DNAPK P78527 human Chk2 11200 O96017 CHEK2 human T68 447491 SsLEtVstQELYsIP X X 2197; 2661; 28130; 12812; 82263; 64180; 59068 +PRKDC DNAPK P78527 human Ku70 2547 P12956 XRCC6 human S33 50247606 AsGDykYsGRDsLIF X +PRKDC DNAPK P78527 human CASP2 835 P42575 CASP2 human S139 6835500 LSCDYDLsLPFPVCE X X +PRKDC DNAPK P78527 human RFA2 6118 P15927 RPA2 human T21 448340 yGGAGGYtQsPGGFG X X +PRKDC DNAPK P78527 human H2AX 3014 P16104 H2AX human S139 448841 GkkAtQAsQEy____ X X 2577; 9719; 9720; 9718; 4309; 5763; 5438; 93629; 80312; 20304; 85410; 97148; 60566; 59141 +PRKDC DNAPK P78527 human TGM2 7052 P21980 TGM2 human T162 1874101934 ERQEyVLtQQGFIYQ X +PRKDC DNAPK P78527 human AMPKG1 5571 P54619 PRKAG1 human S192 1827354809 KPEFMSKsLEELQIG CBS X X +PRKDC DNAPK P78527 human hnRNP P2 2521 P35637 FUS human S87 179463703 GYGSsQSsQSSYGQQ X +PRKDC DNAPK P78527 human NHEJ1 79840 Q9H9Q4 NHEJ1 human S251 4084900 AsLQGIDsQCVNQPE X +PRKDC DNAPK P78527 human ZIC2 22772 Q62520 Zic2 mouse S200 1783002 EQYRQVAsPRTDPYS X +PRKDC DNAPK P78527 human Chk2 11200 O96017 CHEK2 human T387 447552 LMRtLCGtPtyLAPE Pkinase X +PRKDC DNAPK P78527 human Oct1 5451 P14859 POU2F1 human S88 483940 sQQPsQPsQQPsVQA X +PRKDC DNAPK P78527 human p53 7157 P04637 TP53 human S15 447490 PsVEPPLsQEtFsDL P53_TAD X X 4030; 9235; 9284; 9286; 8695; 8514; 82530; 56979 +PRKDC DNAPK P78527 human NHEJ1 79840 Q9H9Q4 NHEJ1 human S245 4084901 PHTSNSAsLQGIDsQ X X +PRKDC DNAPK P78527 human Oct1 5451 P14859 POU2F1 human S143 483944 AVQQHsAsQQHsAAG X +PRKDC DNAPK P78527 human TDP1 55775 Q9NUW8 TDP1 human S81 11279401 PKRQKsGsQEDLGWC X X +PRKDC DNAPK P78527 human USF1 7391 P22415 USF1 human S262 7367003 RQSNHRLsEELQGLD X +PRKDC DNAPK P78527 human PARP1 142 P09874 PARP1 human T594 1876872802 RSWGRVGtVIGSNkL WGR X +PRKDC DNAPK P78527 human NHEJ1 79840 Q9H9Q4 NHEJ1 human T223 4084906 DLYMAVTtQEVQVGQ X +PRKDC DNAPK P78527 human DNAPK 5591 P78527 PRKDC human S2056 455794 VQsYsYSsQDPRPAT DNAPKcs_CC3 X X 68716 +PRKDC DNAPK P78527 human NHEJ1 79840 Q9H9Q4 NHEJ1 human S132 4084905 LASPSLVsQHLIRPL XLF X +PRKDC DNAPK P78527 human VCP 7415 P55072 VCP human S784 456210 NQGGAGPsQGsGGGt X +PRKDC DNAPK P78527 human Artemis 64421 Q96SD1 DCLRE1C human S534 460661 GESTHISsQNSsQST X +PRKDC DNAPK P78527 human PNPT1 87178 Q8TCS8 PNPT1 human S776 482067 IVMGEPIsQSSSNsQ X X +PRKDC DNAPK P78527 human Vimentin 7431 P08670 VIM human S56 451514 srsLyAssPGGVyAt Filament_head X 3877; 7391 +PRKDC DNAPK P78527 human Chk2 11200 O96017 CHEK2 human T383 447545 GEtsLMRtLCGtPty Pkinase X +PRKDC DNAPK P78527 human Akt1 207 P31749 AKT1 human T308 447856 kDGAtMKtFCGtPEy Pkinase X 5106; 2965; 9275; 4056; 5056; 13842; 13038; 43506; 48646; 86758; 80722; 77440; 80556 +PRKDC DNAPK P78527 human hnRNP P2 2521 P35637 FUS human T7 179463705 _MASNDYtQQAtQSY X +PRKDC DNAPK P78527 human hnRNP P2 2521 P35637 FUS human S112 283458500 APSSTSGsYGSSsQS X +Erbb2 HER2 P06494 rat HER2 24337 P06494 Erbb2 rat Y1250 447614 PTAENPEyLGLDVPV X 2247 +Erbb2 HER2 P06494 rat HER2 24337 P06494 Erbb2 rat Y1223 449744 SPAFDNLyyWDQNSS X +Erbb2 HER2 P06494 rat HER2 24337 P06494 Erbb2 rat Y1198 448676 GAVENPEyLVPREGT X +Erbb2 HER2 P06494 rat HER2 24337 P06494 Erbb2 rat Y1224 448675 PAFDNLyyWDQNSSE X +Erbb2 HER2 P06494 rat PTPRE 19267 P49446 Ptpre mouse Y695 450705 FIDIFSDyANFK___ X +Erbb2 HER2 P06494 rat HER2 24337 P06494 Erbb2 rat Y1141 448678 ACSPQPEyVNQSEVQ X +RIOK3 RIOK3 O14730 human MDA5 64135 Q9BYX4 IFIH1 human S828 40587800 GRARADEsTYVLVAH X X +MAP3K12 DLK Q12852 human H3 291159 Q6LED0 Hist1h2ail1 rat T11 455680 kQTARkstGGkAPRk Histone X X 9767; 9764 +MAP3K12 DLK Q12852 human MRLC2 103910 O14950 MYL12B human S20 448595 KRPQRAtsNVFAMFD X +MAP3K12 DLK Q12852 human MRLC2 103910 O14950 MYL12B human T19 448596 KKRPQRAtsNVFAMF X +Pink1 PINK1 Q99MQ3 mouse UBB 22187 P0CG49 Ubb mouse S65 40515012 DYNIQkEsTLHLVLR ubiquitin X +Pink1 PINK1 Q99MQ3 mouse XBP1 22433 O35426 Xbp1 mouse S61 21688102 RQRLTHLsPEEKALR bZIP_1 X +Pink1 PINK1 Q99MQ3 mouse LETM1 3954 O95202 LETM1 human T192 384464302 ILNGHsLtRRERRQF LETM1_RBD X +Pink1 PINK1 Q99MQ3 mouse XBP1 22433 O35426 Xbp1 mouse T48 21688103 AGSEASGtPQARKRQ X X +Pink1 PINK1 Q99MQ3 mouse ubiquitin P62991 UBA52-RPS27A-UBB-UBC mouse S65 9765472 DYNIQkEstLHLVLR ubiquitin X X 43163; 37642; 62802; 70973; 83816; 88503 +PKN1 PKN1 Q16512 human Tau iso8 4137 P10636-8 MAPT human S352 487459 DFKDrVQskIGsLDN Tubulin-binding X +PKN1 PKN1 Q16512 human MARCKS 17118 P26645 Marcks mouse S163 451837 sFkLsGFsFKKsKKE MARCKS X 8722 +PKN1 PKN1 Q16512 human Tau iso8 4137 P10636-8 MAPT human S320 450139 VDLskVtskCGsLGN Tubulin-binding X X +PKN1 PKN1 Q16512 human EGFR 1956 P00533 EGFR human T678 448053 RHIVRKRtLRRLLQE X X 14343 +PKN1 PKN1 Q16512 human HDAC5 10014 Q9UQL6 HDAC5 human T292 13204426 KDGtVIstFKKRAVE X +PKN1 PKN1 Q16512 human H3 8350 P68431 H3C1 human T11 455680 kQtArkstGGkAPrk Histone X X 9767; 9764 +PKN1 PKN1 Q16512 human MARCKS 17118 P26645 Marcks mouse S152 447786 kkKKKRFsFKKsFkL MARCKS X 2741; 11992 +PKN1 PKN1 Q16512 human Tau iso8 4137 P10636-8 MAPT human S258 487453 PDLkNVKskIGstEN Tubulin-binding X +PKN1 PKN1 Q16512 human TRAF1 22029 P39428 Traf1 mouse S139 26331402 MALERNLsELQLQAA X +PKN1 PKN1 Q16512 human Tau iso8 4137 P10636-8 MAPT human S214 447929 GsRsRtPsLPtPPtR X 77348 +PKN1 PKN1 Q16512 human HDAC9 9734 Q9UKV0 HDAC9 human S253 13204427 KDGNVVTsFKKRMFE X +PKN1 PKN1 Q16512 human MARCKS 17118 P26645 Marcks mouse S156 447787 KRFsFKKsFkLsGFs MARCKS X 2741; 11992 +PKN1 PKN1 Q16512 human pyrin 4210 O15553 MEFV human S208 455897 VRLRRNAssAGRLQG X X +PKN1 PKN1 Q16512 human Restin 6249 P30622 CLIP1 human S312 4769833 AsLKRsPsAssLsSM X +PKN1 PKN1 Q16512 human PKN1 5585 Q16512 PKN1 human T774 447835 GyGDRtstFCGtPEF Pkinase X 2611 +PKN1 PKN1 Q16512 human pyrin 4210 O15553 MEFV human S242 455899 SGKMRPRsLEVTIST X X +Wnk1 WNK1 P83741 mouse OSR1 108737 Q6P9R2 Oxsr1 mouse S325 456504 VRRVPGssGRLHKtE X +Wnk1 WNK1 P83741 mouse OSR1 108737 Q6P9R2 Oxsr1 mouse T185 456503 TRNKVRKtFVGtPCW Pkinase X +SMG1 SMG1 Q96Q15 human RENT1 5976 Q92900 UPF1 human T28 21560213 AELLGADtQGsEFEF X X +SMG1 SMG1 Q96Q15 human RENT1 5976 Q92900 UPF1 human S1089 12559503 GLsQPELsQDSYLGD X X +SMG1 SMG1 Q96Q15 human RENT1 19704 Q9EPU0 Upf1 mouse T28 21560213 AELLGADtQGSEFEF X +SMG1 SMG1 Q96Q15 human RENT1 5976 Q92900 UPF1 human S1127 460825 HGGVTGLsQy_____ X +SMG1 SMG1 Q96Q15 human RENT1 5976 Q92900 UPF1 human S1107 456314 sQIDVALsQDstyQG X X 84283 +SMG1 SMG1 Q96Q15 human RENT1 5976 Q92900 UPF1 human S1084 12559504 QMSQPGLsQPELsQD X +SMG1 SMG1 Q96Q15 human p53 7157 P04637 TP53 human S15 447490 PsVEPPLsQEtFsDL P53_TAD X 4030; 9235; 9284; 9286; 8695; 8514; 82530; 56979 +MAP3K6 MEKK6 O95382 human JNK1 5599 P45983 MAPK8 human Y185 447645 tsFMMtPyVVtRYYR Pkinase X 5136; 4668; 4671; 9257; 9255; 9251; 4306; 5755; 16014; 58328 +MAP3K6 MEKK6 O95382 human ASK1 26408 O35099 Map3k5 mouse T845 448394 GINPCtEtFTGtLQY Pkinase X 3765 +MAP3K6 MEKK6 O95382 human JNK1 5599 P45983 MAPK8 human T183 447643 AGtsFMMtPyVVtRY Pkinase X 5136; 4668; 4671; 9257; 9255; 9251; 4306; 5755; 16014; 58328 +MAP3K6 MEKK6 O95382 human MEKK6 9064 O95382 MAP3K6 human T806 7444883 GItPCTEtFTGTLQY Pkinase X X +MAP3K6 MEKK6 O95382 human P38A 1432 Q16539 MAPK14 human T180 447970 RHtDDEMtGyVAtRW Pkinase X 9211; 9215; 4551; 9216; 4552; 4631; 4511; 4092; 9219; 24678; 8632; 6908; 41768; 51255; 14594; 14598; 62979 +MAP3K6 MEKK6 O95382 human P38A 1432 Q16539 MAPK14 human Y182 447971 tDDEMtGyVAtRWYR Pkinase X 9211; 9215; 4551; 9216; 4552; 4631; 4511; 4092; 9219; 24678; 8632; 6908; 41768; 51255; 14594; 14598; 62979 +DAPK1 DAPK1 P53355 human RIGI 23586 O95786 RIGI human S654 63044902 IEGNPkLsFLkPGIL Helicase_C X +DAPK1 DAPK1 P53355 human CAMKK2 10645 Q96RR4 CAMKK2 human S511 2861414 RREERsLsAPGNLLT X X 12818 +DAPK1 DAPK1 P53355 human HSF1 3297 Q00613 HSF1 human S230 448072 PkYSRQFsLEHVHGS X X +DAPK1 DAPK1 P53355 human p53 7157 P04637 TP53 human T18 447541 EPPLsQEtFsDLWkL P53_TAD X 2529 +DAPK1 DAPK1 P53355 human PIN1 5300 Q13526 PIN1 human S71 18710000 HsQSRRPssWRQEKI Rotamase X X +DAPK1 DAPK1 P53355 human PIN1 23988 Q9QUR7 Pin1 mouse S73 18710000 HSQSRRPsSWRQEKI Rotamase X +DAPK1 DAPK1 P53355 human DAPK1 1612 P53355 DAPK1 human S289 457379 QALSRKAsAVNMEkF X +DAPK1 DAPK1 P53355 human RIGI 23586 O95786 RIGI human T671 63044901 RGktNQNtGMtLPAQ Helicase_C X +DAPK1 DAPK1 P53355 human DAPK1 69635 Q80YE7 Dapk1 mouse S308 448142 ARKKWKQsVRLISLC X +DAPK1 DAPK1 P53355 human p53 7157 P04637 TP53 human S269 17677100 GNLLGRNsFEVRVCA P53 X +DAPK1 DAPK1 P53355 human TPM1 7168 P09493 TPM1 human S283 451804 HALNDMtsI______ Tropomyosin X X +DAPK1 DAPK1 P53355 human NMDAR2B 2904 Q13224 GRIN2B human S1303 450171 NKLRRQHsyDtFVDL NMDAR2_C X 20274; 71335 +DAPK1 DAPK1 P53355 human RIGI 23586 O95786 RIGI human S764 63044903 kEkMMNDsILRLQtW X +DAPK1 DAPK1 P53355 human DAPK1 1612 P53355 DAPK1 human S308 448142 ARKKWkQsVRLISLC X X +DAPK1 DAPK1 P53355 human RIGI 23586 O95786 RIGI human T770 17484200 DsILRLQtWDEAVFR X +DAPK1 DAPK1 P53355 human RPL13A 23521 P40429 RPL13A human S77 5594501 PYHFrAPsRIFWRTV Ribosomal_L13 X +DAPK1 DAPK1 P53355 human MRLC2 103910 O14950 MYL12B human S20 448595 KRPQRAtsNVFAMFD X +DAPK1 DAPK1 P53355 human RIGI 23586 O95786 RIGI human S8 12613701 MTTEQRRsLQAFQDY CARD_2 X +DAPK1 DAPK1 P53355 human beclin 1 8678 Q14457 BECN1 human T119 6406000 LSRRLkVtGDLFDIM BH3 X X +DAPK1 DAPK1 P53355 human p53 7157 P04637 TP53 human S20 447529 PLsQEtFsDLWkLLP P53_TAD X X 9287 +DAPK1 DAPK1 P53355 human RIGI 23586 O95786 RIGI human T674 63044904 tNQNtGMtLPAQkCI Helicase_C X +DAPK1 DAPK1 P53355 human MRLC1 10398 P24844 MYL9 human S20 1863500 KRPQRAtsNVFAMFD X 3674; 3671; 3675; 95777 +DAPK1 DAPK1 P53355 human MCM3 4172 P25205 MCM3 human S160 2201400 KtIERRysDLttLVA MCM_OB X X +DAPK1 DAPK1 P53355 human PELI1 57162 Q96FA3 PELI1 human S39 1870773105 GDRGRRKsRFALFKR Pellino X X +DAPK1 DAPK1 P53355 human NMDAR2B 14812 Q01097 Grin2b mouse S1303 450171 NKLRRQHsyDtFVDL NMDAR2_C X 20274; 71335 +DAPK1 DAPK1 P53355 human RIGI 23586 O95786 RIGI human T667 63044900 ILTGRGktNQNtGMt Helicase_C X +DAPK1 DAPK1 P53355 human STX1A 116470 P32851 Stx1a rat S188 448071 IIMDSSIsKQALSEI Syntaxin X X +PRKD1 PRKD1 Q15139 human HDAC7 51564 Q8WUI4 HDAC7 human S486 452459 RPLsRAQssPAAPAs X 3424 +PRKD1 PRKD1 Q15139 human ATP7B 540 P35670 ATP7B human S1453 11267005 DDDGDKWsLLLNGRD X +PRKD1 PRKD1 Q15139 human COL4A3BP 10087 Q9Y5P4 CERT1 human S132 483985 ssLRRHGsMVsLVsG X X +PRKD1 PRKD1 Q15139 human CTNNB1 1499 P35222 CTNNB1 human T120 6406005 QFdAAHPtNVQRLAE X X +PRKD1 PRKD1 Q15139 human CACNA1C 100101555 P15381 CACB rabbit S1928 455278 ASLGRRAsFHLECLK CAC1F_C X +PRKD1 PRKD1 Q15139 human DLC1 10395 Q96QB1 DLC1 human S1244 17538201 NtLKRENsSPRVMQR X X +PRKD1 PRKD1 Q15139 human DRP1 10059 O00429 DNM1L human S637 483971 VPVARKLsAREQRDC X 4867; 6319 +PRKD1 PRKD1 Q15139 human CTNNB1 1499 P35222 CTNNB1 human T112 3075001 EGMQIPstQFdAAHP X X +PRKD1 PRKD1 Q15139 human AMPKA2 108079 Q8BRK8 Prkaa2 mouse S491 450432 stPQRSCsAAGLHRA AdenylateSensor X +PRKD1 PRKD1 Q15139 human TLR5 7100 O60602 TLR5 human S805 482842 yQLMKHQsIRGFVQK TIR X X +PRKD1 PRKD1 Q15139 human REM1 28954 O75628 REM1 human S18 4697668 TPLHRRAstPLPLsP X X +PRKD1 PRKD1 Q15139 human PIK3R1 18708 P26450 Pik3r1 mouse S652 20831301 TFLVRESsKQGCYAC SH2 X X +PRKD1 PRKD1 Q15139 human SPHK2 56848 Q9NRA0 SPHK2 human S421 486447 sPLHRsVsDLPLPLP X +PRKD1 PRKD1 Q15139 human ASK1 4217 Q99683 MAP3K5 human T838 448394 GINPCTEtFTGtLQY Pkinase X 3765 +PRKD1 PRKD1 Q15139 human PLEKHG5 269608 Q66T02 Plekhg5 mouse S92 27528601 SVLARNVsTRSCPPR X +PRKD1 PRKD1 Q15139 human ATP7B 540 P35670 ATP7B human S1121 11267007 AHSERPLsAPASHLN Hydrolase X +PRKD1 PRKD1 Q15139 human PAK4 10298 O96013 PAK4 human S99 2192540 MsVTRsNsLRRDsPP X X +PRKD1 PRKD1 Q15139 human PIK3R1 5295 P27986 PIK3R1 human S154 7445250 stLYRtQsSSNLAEL RhoGAP X X +PRKD1 PRKD1 Q15139 human Akt1 207 P31749 AKT1 human S473 447855 RPHFPQFsysAsGtA Pkinase_C X 9271; 3787; 4060; 4051; 5102; 4058; 2336; 2337; 4075; 4070; 5012; 4071; 92982; 5315; 9563; 9018; 12694; 52240; 11962; 15116; 88106; 26580; 68035; 31957; 23430; 20235 +PRKD1 PRKD1 Q15139 human PPP1R14A 94274 Q96A00 PPP1R14A human T38 449098 QkRHARVtVkYDRRE PP1_inhibitor X +PRKD1 PRKD1 Q15139 human OSBP P16258 OSBP rabbit S242 484804 TALQRSLsELESLKL X X +PRKD1 PRKD1 Q15139 human MYST2 11143 O95251 KAT7 human T97 3178404 kKYPLRQtRssGsEt X X +PRKD1 PRKD1 Q15139 human MYBPC3 4607 Q14896 MYBPC3 human S304 471081 SLLKKRDsFRtPRDs X +PRKD1 PRKD1 Q15139 human PIP5K1C 23396 O60331 PIP5K1C human S448 17550224 NTVFRKNsSLKSsPS X +PRKD1 PRKD1 Q15139 human CDH2 83501 Q9Z1Y3 Cdh2 rat S871 382737700 GSTAGsLssLNSSSS CADH_Y-type_LIR X +PRKD1 PRKD1 Q15139 human PRKD1 85421 Q9WTQ1 Prkd1 rat S748 448590 GEKsFRRsVVGTPAY Pkinase X +PRKD1 PRKD1 Q15139 human Syk 20963 P48025 Syk mouse S291 1983707 ISRIKsysFPKPGHK X +PRKD1 PRKD1 Q15139 human DRD1 24316 P18901 Drd1 rat S421 30310300 EKLSPALsVILDYDt X X +PRKD1 PRKD1 Q15139 human PIK4CB iso2 5298 Q9UBF8-2 PI4KB human S294 457621 SNLKRtAsNPKVENE X X +PRKD1 PRKD1 Q15139 human PTRH2 51651 Q9Y3E5 PTRH2 human S5 4206801 ___MPSKsLVMEYLA X +PRKD1 PRKD1 Q15139 human TNNI3 29248 P23693 Tnni3 rat S23 448423 PAPVRRRssANYRAY Troponin-I_N X 4004 +PRKD1 PRKD1 Q15139 human RTKN iso2 6242 Q9BST9-2 RTKN human S435 15423057 QALAKQGsLYHEMAI X X +PRKD1 PRKD1 Q15139 human Cortactin 2017 Q14247 CTTN human S298 5014901 EKLAkHEsQQDyskG HS1_rep X X +PRKD1 PRKD1 Q15139 human ATP7B 540 P35670 ATP7B human S481 11267006 ILAKsPQsTRAVAPQ X +PRKD1 PRKD1 Q15139 human CDH2 83501 Q9Z1Y3 Cdh2 rat S872 382737702 STAGsLssLNSSSSG CADH_Y-type_LIR X +PRKD1 PRKD1 Q15139 human AP-2 alpha 7020 P05549 TFAP2A human S258 5024712 GVLRRAKsKNGGRSL TF_AP-2 X +PRKD1 PRKD1 Q15139 human PRKD1 5587 Q15139 PRKD1 human S910 447632 KALGERVsIL_____ X X 2051; 75148 +PRKD1 PRKD1 Q15139 human OXTR 25342 P70536 Oxtr rat S261 1876282800 AALARVSsVKLISKA 7tm_1 X X +PRKD1 PRKD1 Q15139 human Rin1 9610 Q13671 RIN1 human S351 451364 RPLLRsMsAAFCSLL X X +PRKD1 PRKD1 Q15139 human AHCYL1 229709 Q80SW1 Ahcyl1 mouse S68 467244 RSLSRsIsQsstDsy X +PRKD1 PRKD1 Q15139 human ITGB4 iso2 3691 P16144-2 ITGB4 human T1736 1243302 EFVSRTLttSGTLST X X +PRKD1 PRKD1 Q15139 human PIK4CB 5298 Q9UBF8 PI4KB human S294 457621 SNLkRTAsNPKVENE X +PRKD1 PRKD1 Q15139 human AP2B1 163 P63010 AP2B1 human Y277 462925 LPkDsDyyNMLLkKL Adaptin_N X +PRKD1 PRKD1 Q15139 human OXTR 5021 P30559 OXTR human S261 1876282802 RVALARVsSVKLISK 7tm_1 X X +PRKD1 PRKD1 Q15139 human AP2B1 163 P63010 AP2B1 human S258 178605774 ANSAVVLsAVKVLMk Adaptin_N X +PRKD1 PRKD1 Q15139 human BAD 572 Q92934 BAD human S99 447862 PFrGrsRsAPPNLWA Bcl-2_BAD X 9295; 5286; 4366 +PRKD1 PRKD1 Q15139 human ATP7B 540 P35670 ATP7B human S478 11267008 APDILAKsPQsTRAV X +PRKD1 PRKD1 Q15139 human MFF 56947 Q9GZY8 MFF human S172 484865 GQLVRNDsLWHRsDs Miff X X +PRKD1 PRKD1 Q15139 human TNNI3 21954 P48787 Tnni3 mouse S24 448424 APVRRRssANyRAYA Troponin-I_N X +PRKD1 PRKD1 Q15139 human AP-2 alpha 7020 P05549 TFAP2A human S326 5024711 EFLNRQHsDPNEQVT TF_AP-2 X +PRKD1 PRKD1 Q15139 human HPK1 11184 Q92918 MAP4K1 human S171 455474 AtLARRLsFIGtPyW Pkinase X +PRKD1 PRKD1 Q15139 human TLR4 7099 O00206 TLR4 human S790 14932401 VELYRLLsRNTYLEW TIR X +PRKD1 PRKD1 Q15139 human HSP27 3315 P04792 HSPB1 human S82 448403 RALsRQLssGVsEIr X X 2406; 2401; 9709; 11892; 64293 +PRKD1 PRKD1 Q15139 human Telethonin 8557 O15273 TCAP human S157 448693 GALRRsLsRSMsQEA Telethonin X +PRKD1 PRKD1 Q15139 human HDAC7 51564 Q8WUI4 HDAC7 human S155 455620 FPLRKtVsEPNLkLR X 3443 +PRKD1 PRKD1 Q15139 human AMPKA1 105787 Q5EG47 Prkaa1 mouse S494 4717473 GtAtPQRsGsIsNYR AdenylateSensor X +PRKD1 PRKD1 Q15139 human SSH1 54434 Q8WYL5 SSH1 human S978 455275 sPLKRSHsLAKLGSL X X +PRKD1 PRKD1 Q15139 human BAD 572 Q92934 BAD human S75 447860 EIRsRHssyPAGtED Bcl-2_BAD X X 9291; 5284; 9296; 5193; 11865; 94223 +PRKD1 PRKD1 Q15139 human HDAC5 10014 Q9UQL6 HDAC5 human S498 447996 RPLSRtQsSPLPQsP X X 3424 +PRKD1 PRKD1 Q15139 human PAK5 57144 Q9P286 PAK5 human S99 29574070 ISVTRSNsLRKESPP X +PRKD1 PRKD1 Q15139 human CREB 1385 P16220 CREB1 human S119 448228 EILsRRPsyRkILND pKID X X 9187; 9196; 9198; 4095; 14228; 14001; 39561; 80120; 44864; 54960; 95995 +PRKD1 PRKD1 Q15139 human MFF 56947 Q9GZY8 MFF human S275 20651869 DNVRYGIsNIDTTIE Miff X X +PRKD1 PRKD1 Q15139 human PAK4 10298 O96013 PAK4 human S474 448023 kEVPRRksLVGtPyW Pkinase X 3241 +PRKD1 PRKD1 Q15139 human MARK2 2011 Q7KZI7 MARK2 human S400 5635600 HkVQRsVsANPKQRR X +PRKD1 PRKD1 Q15139 human CDH2 83501 Q9Z1Y3 Cdh2 rat S869 382737701 GSGSTAGsLssLNSS CADH_Y-type_LIR X +PRKD1 PRKD1 Q15139 human RABEP1 9135 Q15276 RABEP1 human S407 468548 DGLRRAQstDsLGts Rabaptin X +PRKD1 PRKD1 Q15139 human CREB iso1 1385 P16220-1 CREB1 human S98 1207200 KDLKRLFsGtQISTI X +PRKD1 PRKD1 Q15139 human PRKD1 85421 Q9WTQ1 Prkd1 rat S916 447632 KALSERVsIL_____ X +PRKD1 PRKD1 Q15139 human MYST2 11143 O95251 KAT7 human T331 18911980 LRLQGQItEGsNMIk X X +PRKD1 PRKD1 Q15139 human PRKD1 85421 Q9WTQ1 Prkd1 rat S744 448589 ARIIGEKsFRRsVVG Pkinase X +PRKD1 PRKD1 Q15139 human BAD 572 Q92934 BAD human S118 447863 GRELRRMsDEFVDsF Bcl-2_BAD X X 9297 +PRKD1 PRKD1 Q15139 human SPHK2 56848 Q9NRA0 SPHK2 human S419 486446 AHsPLHRsVsDLPLP X +PRKD1 PRKD1 Q15139 human PLEKHG5 269608 Q66T02 Plekhg5 mouse S806 27434500 PTILRKSsNSLDSEH X +PRKD1 PRKD1 Q15139 human PRKD1 5587 Q15139 PRKD1 human S738 448589 ARIIGEksFRRsVVG Pkinase X 2054 +PRKD1 PRKD1 Q15139 human HDAC7 51564 Q8WUI4 HDAC7 human S358 455621 WPLsRtRsEPLPPsA X +PRKD1 PRKD1 Q15139 human CACNA1C 775 Q13936 CACNA1C human S1981 455278 ASLGRRAsFHLECLK X +PRKD1 PRKD1 Q15139 human Cortactin 2017 Q14247 CTTN human S348 5014900 EAVTskTsNIRANFE X X +PRKD1 PRKD1 Q15139 human Jun 3725 P05412 JUN human S63 447686 kNsDLLtsPDVGLLk Jun X 5464; 9261; 2361; 97721; 91952 +PRKD1 PRKD1 Q15139 human TNNI3 21954 P48787 Tnni3 mouse S23 448423 PAPVRRRssANyRAY Troponin-I_N X +PRKD1 PRKD1 Q15139 human PIP4K2A 5305 P48426 PIP4K2A human T376 460716 KAAHAAktVKHGAGA PIP5K X X +PRKD1 PRKD1 Q15139 human Kv11.1 3757 Q12809 KCNH2 human S284 4696786 ASVRRAssADDIEAM X +PRKD1 PRKD1 Q15139 human KIDINS220 116478 Q9EQG6 Kidins220 rat S918 451418 RTITRQMsFDLTKLL KAP_NTPase X X +PRKD1 PRKD1 Q15139 human SPRY2 10253 O43597 SPRY2 human S112 465675 APLSRSIsTVssGsR X +PRKD1 PRKD1 Q15139 human arfaptin 1 27236 P53367 ARFIP1 human S132 3191827 LELVRKWsLNtyKCT Arfaptin X X +PRKD1 PRKD1 Q15139 human PTRH2 51651 Q9Y3E5 PTRH2 human S87 4206800 GkVAAQCsHAAVSAy PTH2 X X +PRKD1 PRKD1 Q15139 human TNNI3 29248 P23693 Tnni3 rat S24 448424 APVRRRssANYRAYA Troponin-I_N X 4004 +PRKD1 PRKD1 Q15139 human FAM83G 644815 A6ND36 FAM83G human S356 3147942 YALVKAKsVDEIAKI X X +PRKD1 PRKD1 Q15139 human SSH1 54434 Q8WYL5 SSH1 human S402 10989184 MGVSRsAstVIAyAM DSPc X +PRKD1 PRKD1 Q15139 human PAK4 10298 O96013 PAK4 human S181 2192531 SRDKRPLsGPDVGtP X X +PRKD1 PRKD1 Q15139 human MBP iso5 4155 P02686-5 MBP human S162 456582 FKLGGRDsRSGSPMA Myelin_MBP X +PRKD1 PRKD1 Q15139 human Cofilin-1 1072 P23528 CFL1 human S3 448444 _____MAsGVAVsDG X 3313; 3311 +PRKD1 PRKD1 Q15139 human HDAC5 10014 Q9UQL6 HDAC5 human S259 447995 FPLRkTAsEPNLKVR X 3443 +PRKD1 PRKD1 Q15139 human NLRP3 216799 Q8R4B8 Nlrp3 mouse S291 57761902 CKILRKPsRILFLMD NACHT X +PRKD1 PRKD1 Q15139 human Rin1 9610 Q13671 RIN1 human S292 4949757 QLLRREssVGyRVPA X X +PRKD1 PRKD1 Q15139 human SSH1 54434 Q8WYL5 SSH1 human S937 455274 SNLtRssssDsIHsV X X +PRKD1 PRKD1 Q15139 human MFF 56947 Q9GZY8 MFF human S155 470753 GRLkRERsMsENAVR Miff X X +PRKD1 PRKD1 Q15139 human PRKD1 5587 Q15139 PRKD1 human S742 448590 GEksFRRsVVGtPAy Pkinase X +PRKD1 PRKD1 Q15139 human Snail1 6615 O95863 SNAI1 human S11 11493500 SFLVRKPsDPNRKPN X X +PRKD1 PRKD1 Q15139 human OSBP 5007 P22059 OSBP human S240 484804 tALQRsLsELESLkL X +PRKD1 PRKD1 Q15139 human VASP 7408 P50552 VASP human S157 448379 EHIERRVsNAGGPPA X X 3111; 84519 +PRKD1 PRKD1 Q15139 human HSP20 126393 O14558 HSPB6 human S16 450706 PSWLRRAsAPLPGLS Crystallin X X 36519 +PRKD1 PRKD1 Q15139 human VASP 7408 P50552 VASP human S322 469024 TtLPRMkssssVttS X X +PRKD1 PRKD1 Q15139 human AP-2 alpha 21418 P34056 Tfap2a mouse S258 5024712 GVLRRAKsKNGGrSL TF_AP-2 X +PRKD1 PRKD1 Q15139 human Akt1 207 P31749 AKT1 human T308 447856 kDGAtMKtFCGtPEy Pkinase X 5106; 2965; 9275; 4056; 5056; 13842; 13038; 43506; 48646; 86758; 80722; 77440; 80556 +PRKD1 PRKD1 Q15139 human Telethonin 8557 O15273 TCAP human S161 3893741 RsLsRSMsQEAQRG_ Telethonin X +MAP3K7 TAK1 O43318 human RCAN1 266766 Q6IN33 Rcan1 rat S94 6374005 QTLHIGssHLAPPNP Calcipressin X X +MAP3K7 TAK1 O43318 human TUBA1B 10376 P68363 TUBA1B human T334 3653841 DVNAAIAtIktkrsI Tubulin_C X +MAP3K7 TAK1 O43318 human RCAN1 266766 Q6IN33 Rcan1 rat S136 6374004 YDLLYAIsKLGPGEK Calcipressin X X +MAP3K7 TAK1 O43318 human PTPN3 5774 P26045 PTPN3 human S359 451191 PAMRRsLsVEHLETK X +MAP3K7 TAK1 O43318 human EIF4B 1975 P23588 EIF4B human S230 4333942 kyRDRyDsDRyRDGy X +MAP3K7 TAK1 O43318 human hnRNP A2/B1 3181 P22626 HNRNPA2B1 human T176 476090 IVLQkyHtINGHNAE RRM_1 X +MAP3K7 TAK1 O43318 human FLNA 2316 P21333 FLNA human T1286 10787026 sVDARALtQtGGPHV Filamin X +MAP3K7 TAK1 O43318 human RBMX 27316 P38159 RBMX human T216 3887573 PRDDGystkDsyssR RBM1CTR X +MAP3K7 TAK1 O43318 human TAK1 6885 O43318 MAP3K7 human T184 454876 GtACDIQtHMtNNKG PK_Tyr_Ser-Thr X X 4531; 4508; 4537 +MAP3K7 TAK1 O43318 human TAB1 10454 Q15750 TAB1 human S452 22869801 STNTHTQssSSssDG X X +MAP3K7 TAK1 O43318 human TAK1 6885 O43318 MAP3K7 human S192 448289 HMtNNKGsAAWMAPE PK_Tyr_Ser-Thr X +MAP3K7 TAK1 O43318 human plakophilin 2 5318 Q99959 PKP2 human S82 468460 GNLHRtssVPEyVyN X X +MAP3K7 TAK1 O43318 human TAB1 10454 Q15750 TAB1 human S456 22869802 HTQssSSssDGGLFR X X +MAP3K7 TAK1 O43318 human HIPK2 28996 Q9H2X6 HIPK2 human Y361 449571 SkAVCstyLQsRYyR Pkinase X +MAP3K7 TAK1 O43318 human GRP94 7184 P14625 HSP90B1 human S674 31855603 yQtGkDIstNyyAsQ HSP90 X +MAP3K7 TAK1 O43318 human GRP94 7184 P14625 HSP90B1 human T669 38485693 MkAQAyQtGkDIstN HSP90 X +MAP3K7 TAK1 O43318 human GRP94 7184 P14625 HSP90B1 human T675 57812706 QtGkDIstNyyAsQk HSP90 X +MAP3K7 TAK1 O43318 human RAB1A 5861 P62820 RAB1A human T75 1247157 AGQERFRtItSSyyR Ras X X +MAP3K7 TAK1 O43318 human RAB8A 4218 P61006 RAB8A human T72 4709152 AGQERFRtITTAyyR Ras X +MAP3K7 TAK1 O43318 human CDC25C 995 P30307 CDC25C human S216 448418 sGLyRsPsMPENLNR M-inducer_phosp X X 9528; 4901; 30790 +MAP3K7 TAK1 O43318 human RIPK1 19766 Q60855 Ripk1 mouse S321 468644 PVLQRMFsLQHDCVP X X 83613; 38662 +MAP3K7 TAK1 O43318 human POLD2 5425 P49005 POLD2 human T33 57812708 RVPVATytNSSQPFR X +MAP3K7 TAK1 O43318 human HDAC7 51564 Q8WUI4 HDAC7 human S155 455620 FPLRKtVsEPNLkLR X X 3443 +MAP3K7 TAK1 O43318 human HDAC4 9759 P56524 HDAC4 human S246 448488 FPLRkTAsEPNLKLR X 3443 +MAP3K7 TAK1 O43318 human TUBB 203068 P07437 TUBB human T166 31889875 yPDrIMNtFsVVPsP Tubulin X +MAP3K7 TAK1 O43318 human KSR 8844 Q8IVT5 KSR1 human S406 449297 TRLRRtEsVPsDINN X X 4951 +MAP3K7 TAK1 O43318 human TAB1 10454 Q15750 TAB1 human S457 22869800 TQssSSssDGGLFRS X X +MAP3K7 TAK1 O43318 human TNFAIP8L2 79626 Q6P589 TNFAIP8L2 human S3 56660955 _____MEsFSSKSLA X +MAP3K7 TAK1 O43318 human TAK1 6885 O43318 MAP3K7 human T187 454704 CDIQtHMtNNKGsAA PK_Tyr_Ser-Thr X X 4536; 4531; 4508 +MAP3K7 TAK1 O43318 human TAB1 10454 Q15750 TAB1 human S453 22869803 TNTHTQssSSssDGG X X +MAP3K7 TAK1 O43318 human GAPVD1 26130 Q14C86 GAPVD1 human T1013 10989095 LGPDRFstLtDDPsP X +MAP3K7 TAK1 O43318 human AMPKA2 5563 P54646 PRKAA2 human T172 448026 sDGEFLRtsCGsPNy Pkinase X X 2535; 2531; 5256; 50081; 74281 +MAP3K7 TAK1 O43318 human GAPVD1 26130 Q14C86 GAPVD1 human S1012 57812705 DLGPDRFstLtDDPs X +MAP3K7 TAK1 O43318 human E2F1 1869 Q01094 E2F1 human S337 447869 IVsPPPSsPPSSLTT X +MAP3K7 TAK1 O43318 human IKKB 3551 O14920 IKBKB human S177 447492 AkELDQGsLCtsFVG Pkinase X 2078; 2697; 2694; 14938; 92255; 36516; 36214 +MAP3K7 TAK1 O43318 human ATAT1 79969 Q5SQI0 ATAT1 human S237 1095631200 GDIkPYSsSDREFLK X X +MAP3K7 TAK1 O43318 human HDAC5 10014 Q9UQL6 HDAC5 human S259 447995 FPLRkTAsEPNLKVR X 3443 +MAP3K7 TAK1 O43318 human IKKB 3551 O14920 IKBKB human S181 447489 DQGsLCtsFVGTLQy Pkinase X 2697; 2694; 14938; 92255; 36516; 36214 +MAP3K7 TAK1 O43318 human TAK1 6885 O43318 MAP3K7 human T178 3303400 LKICDFGtACDIQtH PK_Tyr_Ser-Thr X +MAP3K7 TAK1 O43318 human EEF1A1 1915 P68104 EEF1A1 human T261 23101713 ykIGGIGtVPVGrVE GTP_EFTU_D2 X +MAP3K7 TAK1 O43318 human LDH-A 3939 P00338 LDHA human T3 57812707 _____MAtLkDQLIy X +Rps6kb2 P70S6KB Q9Z1M4 mouse S6 20104 P62754 Rps6 mouse S235 448092 IAKRRRLssLRAsts X 5006; 4856; 4857; 4858; 4851; 4803; 2211; 3945; 3985; 5316; 4854; 8520; 48319; 40643; 9865; 38573; 14733; 27036; 34411; 62016; 62788; 81736; 97935; 99457; 15448 +Rps6kb2 P70S6KB Q9Z1M4 mouse S6 20104 P62754 Rps6 mouse S236 448093 AKRRRLssLRAstsK X 5006; 4856; 4857; 4858; 4851; 4803; 2211; 3945; 3985; 5316; 4854; 8520; 48319; 40643; 9865; 38573; 14733; 27036; 34411; 62016; 62788; 81736; 97935; 99457; 15448 +Cdk6 CDK6 Q64261 mouse C/EBP-alpha 12606 P53566 Cebpa mouse S193 1868113505 PPPHPHAsPAHLAAP X X +Cdk6 CDK6 Q64261 mouse Rb 19645 P13405 Rb1 mouse T819 447984 LPtPtKMtPRSRILV Rb_C X +Cdk6 CDK6 Q64261 mouse Rb 19645 P13405 Rb1 mouse S804 448717 IyIsPLksPyKIsEG Rb_C X 9308; 8974; 4277; 40283; 8957; 8516; 11917; 41359; 75864 +Cdk6 CDK6 Q64261 mouse Rb 19645 P13405 Rb1 mouse S243 447975 AAIPINGsPRtPRRG X +Cdk6 CDK6 Q64261 mouse Rb 19645 P13405 Rb1 mouse T246 449821 PINGsPRtPRRGQNR X +Cdk6 CDK6 Q64261 mouse Rb 19645 P13405 Rb1 mouse S800 447980 PGGNIyIsPLksPyK Rb_C X 9308; 8974; 4277; 40283; 8957; 8516; 11917; 41359; 75864; 72443 +Fyn Fyn Q62844 rat CDK5 140908 Q03114 Cdk5 rat Y15 448022 EKIGEGTyGTVFKAK Pkinase X 94254; 19051 +Fyn Fyn Q62844 rat CRMP-1 25415 Q62950 Crmp1 rat Y504 454682 GMyDGPVyEVPAtPk X +Fyn Fyn Q62844 rat NPHS1 64563 Q9R044 Nphs1 rat Y1153 1317600 AEVDPNyySMRDFSP X +Fyn Fyn Q62844 rat ADD2 24171 Q05764 Add2 rat Y489 449419 PNQFVPLyTDPQEVL X +Fyn Fyn Q62844 rat IGF2BP1 303477 Q8CGX0 Igf2bp1 rat Y396 458348 SVTGAAPyGSFMQAP X +KIT Kit P10721 human Kit 3815 P10721 KIT human Y553 13876401 KyLQKPMyEVQWKVV X +KIT Kit P10721 human Kit 3815 P10721 KIT human Y703 448016 DHAEAALyKNLLHSK PK_Tyr_Ser-Thr X 3073 +KIT Kit P10721 human SLAP 6503 Q13239 SLA human Y273 467049 sFFSSPPyFED____ X +KIT Kit P10721 human Kit 3815 P10721 KIT human Y568 448014 EEINGNNyVyIDPTQ X 48347 +KIT Kit P10721 human Kit 3815 P10721 KIT human Y547 13876400 VMILTYKyLQKPMyE X +KIT Kit P10721 human Kit 3815 P10721 KIT human Y936 448019 SEsTNHIysNLANCs X +KIT Kit P10721 human PHB 5245 P35232 PHB1 human Y259 6374000 SRSRNItyLPAGQsV X X +KIT Kit P10721 human Kit 3815 P10721 KIT human Y721 448017 CSDStNEyMDMKPGV PK_Tyr_Ser-Thr X 3391 +KIT Kit P10721 human Kit 16590 P05532 Kit mouse Y706 448016 EQAEAALyKNLLHST PK_Tyr_Ser-Thr X +KIT Kit P10721 human Kit 3815 P10721 KIT human Y570 448015 INGNNyVyIDPTQLP X 48347 +KIT Kit P10721 human LAB 7462 Q9GZY6 LAT2 human Y110 454708 RHGsEEAyIDPIAME LAT2 X +KIT Kit P10721 human SLAP 6503 Q13239 SLA human Y120 15570321 SETKkGFySLSVRHR SH2 X +KIT Kit P10721 human LAB 7462 Q9GZY6 LAT2 human Y118 454709 IDPIAMEyyNWGRFS LAT2 X +KIT Kit P10721 human SLAP 6503 Q13239 SLA human Y258 1018109 KksIsLMyGGskRkS X +KIT Kit P10721 human Kit 3815 P10721 KIT human Y823 448018 DIKNDsNyVVKGNAR PK_Tyr_Ser-Thr X 77522 +EIF2AK2 PKR P19525 human eIF2-alpha 100339093 P83268 EIF2S1 rabbit S51 447635 RILLsELsR______ S1 X 3398; 5199; 95797 +EIF2AK2 PKR P19525 human NFAT90 16201 Q9Z1X4 Ilf3 mouse T188 17734001 EKVLAGEtLsVNDPP DZF X +EIF2AK2 PKR P19525 human PKR 5610 P19525 EIF2AK2 human S242 448085 NQRKAKRsLAPRFDL X X +EIF2AK2 PKR P19525 human PKR 5610 P19525 EIF2AK2 human S83 3181640 NkEKkAVsPLLLttt X +EIF2AK2 PKR P19525 human PKR 5610 P19525 EIF2AK2 human T451 448089 kRtRSKGtLRyMsPE Pkinase X X +EIF2AK2 PKR P19525 human CDK1 983 P06493 CDK1 human Y4 473276 ____MEDytkIEkIG Pkinase X X +EIF2AK2 PKR P19525 human eIF2-alpha 54318 P68101 Eif2s1 rat S52 447635 MILLSELsRRRIRSI S1 X 3597; 9721; 3398; 5199; 53085; 95797 +EIF2AK2 PKR P19525 human PKR 5610 P19525 EIF2AK2 human Y293 458273 HRIDGKTyVIKRVkY Pkinase X X +EIF2AK2 PKR P19525 human Tau iso8 4137 P10636-8 MAPT human S262 447930 NVKskIGstENLkHQ Tubulin-binding X +EIF2AK2 PKR P19525 human JMJD2C 23081 Q9H3R0 KDM4C human S918 1869778705 MFDDGsFsRDTFPED X +EIF2AK2 PKR P19525 human p53 7157 P04637 TP53 human S392 447535 FktEGPDsD______ X X 9281 +EIF2AK2 PKR P19525 human PKR 5610 P19525 EIF2AK2 human T446 448088 LkNDGkRtRSKGtLR Pkinase X X +EIF2AK2 PKR P19525 human PKR 5610 P19525 EIF2AK2 human S6 23132463 __MAGDLsAGFFMEE X +EIF2AK2 PKR P19525 human PKR 5610 P19525 EIF2AK2 human Y162 458272 QLAAkLAyLQILSEE dsrm X X +EIF2AK2 PKR P19525 human eIF2-alpha 1965 P05198 EIF2S1 human S49 450210 IEGMILLsELsRRRI S1 X +EIF2AK2 PKR P19525 human IRS1 16367 P35569 Irs1 mouse S307 447558 tEsITAtsPAsMVGG X 2381 +EIF2AK2 PKR P19525 human PKR 5610 P19525 EIF2AK2 human T255 448086 DLPDMkEtKytVDKR X X +EIF2AK2 PKR P19525 human Tau iso8 4137 P10636-8 MAPT human S356 449104 rVQskIGsLDNItHV Tubulin-binding X +EIF2AK2 PKR P19525 human PKR 5610 P19525 EIF2AK2 human T89 3753307 VsPLLLtttNssEGL X +EIF2AK2 PKR P19525 human eIF2-alpha 100339093 P83268 EIF2S1 rabbit S48 450210 IEGRILLsELsR___ S1 X +EIF2AK2 PKR P19525 human PKR 5610 P19525 EIF2AK2 human T88 3753308 AVsPLLLtttNssEG X +EIF2AK2 PKR P19525 human PPP2R5A 5525 Q15172 PPP2R5A human S28 459127 VDGFTRKsVRKAQRQ X X +EIF2AK2 PKR P19525 human TIF1B 10155 Q13263 TRIM28 human S473 452391 sGVkRsRsGEGEVsG X +EIF2AK2 PKR P19525 human PKR 5610 P19525 EIF2AK2 human T90 3181643 sPLLLtttNssEGLs X +EIF2AK2 PKR P19525 human eIF2-alpha 1965 P05198 EIF2S1 human S52 447635 MILLsELsRRRIRsI S1 X X 3597; 9721; 3398; 5199; 53085; 95797 +EIF2AK2 PKR P19525 human NFAT90 16201 Q9Z1X4 Ilf3 mouse T315 17734000 RQQREDItQSAQHAL DZF X +EIF2AK2 PKR P19525 human PKR 5610 P19525 EIF2AK2 human Y101 458271 EGLsMGNyIGLINRI dsrm X X +EIF2AK2 PKR P19525 human PKR 5610 P19525 EIF2AK2 human T258 448087 DMkEtKytVDKRFGM X X +Igf1r IGF1R Q60751 mouse IGF1R 16001 Q60751 Igf1r mouse Y974 449827 RLGNGVLyASVNPEy X X +Igf1r IGF1R Q60751 mouse IGF1R 16001 Q60751 Igf1r mouse Y981 448390 yASVNPEyFSAADVY X X 4568 +Igf1r IGF1R Q60751 mouse IGF1R 16001 Q60751 Igf1r mouse Y1167 448387 RDIyEtDyyRKGGkG PK_Tyr_Ser-Thr X 3024; 3918; 2969 +Igf1r IGF1R Q60751 mouse IGF1R 16001 Q60751 Igf1r mouse Y1163 448386 FGMTRDIyEtDyyRK PK_Tyr_Ser-Thr X X 3021; 80732 +Igf1r IGF1R Q60751 mouse IGF1R 16001 Q60751 Igf1r mouse Y1352 448389 sFDERQPyAHMNGGR X X 28897 +Igf1r IGF1R Q60751 mouse CRK 12928 Q64010 Crk mouse Y221 447951 GGPEPGPyAQPsVNt X 3491 +Igf1r IGF1R Q60751 mouse IGF1R 16001 Q60751 Igf1r mouse Y1168 448388 DIyEtDyyRKGGkGL PK_Tyr_Ser-Thr X X 3024; 2969 +Trpm7 ChaK1 Q923J1 mouse ChaK1 58800 Q923J1 Trpm7 mouse S1567 455464 NLMRLsQsIPFVPVP X X +Trpm7 ChaK1 Q923J1 mouse ChaK1 58800 Q923J1 Trpm7 mouse S1511 455463 EDsPEVdsKAALLPD X X +Kdr VEGFR2 O08775 rat VEGFR2 25589 O08775 Kdr rat Y1171 447901 AQQDGKDyIVLPMSE X 2478; 3770 +Camkk2 CAMKK2 O88831 rat AMPKA1 65248 P54645 Prkaa1 rat T183 448786 SDGEFLRtsCGSPNY Pkinase X 2535; 2531; 4188; 5256; 50081; 74281 +Camkk2 CAMKK2 O88831 rat CAMK4 25050 P13234 Camk4 rat S11 2827404 VTVPsCPssPCsSVT X +Camkk2 CAMKK2 O88831 rat CAMK4 25050 P13234 Camk4 rat S8 2827402 MLKVTVPsCPssPCs X +Camkk2 CAMKK2 O88831 rat CAMK4 25050 P13234 Camk4 rat S353 2827401 QESNKASsEAQPAQD X +Camkk2 CAMKK2 O88831 rat CAMK4 25050 P13234 Camk4 rat S15 2827405 sCPssPCsSVTSSTE X +EPHA2 EphA2 P29317 human EphA2 1969 P29317 EPHA2 human Y921 457515 ESIKMQQytEHFMAA SAM_1 X +EPHA2 EphA2 P29317 human EphA2 1969 P29317 EPHA2 human Y575 454954 RQsPEDVyFsksEQL EphA2_TM X +EPHA2 EphA2 P29317 human EphA2 1969 P29317 EPHA2 human Y694 461993 PMMIItEyMENGALD PK_Tyr_Ser-Thr X +EPHA2 EphA2 P29317 human EphA2 1969 P29317 EPHA2 human Y628 461992 AGEFGEVykGMLKTS PK_Tyr_Ser-Thr X +EPHA2 EphA2 P29317 human GLO1 2739 Q04760 GLO1 human Y136 463450 GIAVPDVysACkRFE Glyoxalase X +EPHA2 EphA2 P29317 human EphA2 1969 P29317 EPHA2 human Y772 450861 EDDPEAtyttsGGkI PK_Tyr_Ser-Thr X X 8244; 8862 +EPHA2 EphA2 P29317 human EphA2 1969 P29317 EPHA2 human Y960 461994 GHQKRIAysLLGLKD SAM_1 X +EPHA2 EphA2 P29317 human EphA2 1969 P29317 EPHA2 human Y588 450859 QLkPLktyVDPHtyE EphA2_TM X X 12677 +EPHA2 EphA2 P29317 human Claudin-4 1364 O14493 CLDN4 human Y208 451666 RsAAAsNyV______ X +EPHA2 EphA2 P29317 human EphA2 1969 P29317 EPHA2 human Y594 450860 tyVDPHtyEDPNQAV EphA2_TM X X 3970 +EPHA2 EphA2 P29317 human EphA2 1969 P29317 EPHA2 human Y735 473293 kYLANMNyVHRDLAA PK_Tyr_Ser-Thr X X +EPHA2 EphA2 P29317 human Yes 7525 P07947 YES1 human Y426 447619 RLIEDNEytARQGAk PK_Tyr_Ser-Thr X X 2101; 6943; 59548; 70926; 78740; 94361; 17320 +PTK2 FAK Q00944 chicken GIT2 374035 Q9Y621 GIT2 chicken Y286 456753 EELAMYVyDEVDRRE GIT_SHD X +PTK2 FAK Q00944 chicken GIT2 374035 Q9Y621 GIT2 chicken Y392 456754 QDNDQPDyDSVASDE X 11873 +PTK2 FAK Q00944 chicken FAK 396416 Q00944 PTK2 chicken Y397 447887 sVsETDDyAEIIDEE X X 3283; 8556 +PTK2 FAK Q00944 chicken GIT2 374035 Q9Y621 GIT2 chicken Y592 450866 SSVPESDyDNTTASL X +Met Met P97523 rat Met 4233 P08581 MET human Y1234 448470 RDMyDkEyysVHNkt PK_Tyr_Ser-Thr X 4091; 3129; 3126; 3077; 12468; 4033; 98954 +Met Met P97523 rat Met 4233 P08581 MET human Y1235 448471 DMyDkEyysVHNktG PK_Tyr_Ser-Thr X 4091; 3129; 3126; 3077; 12468; 4033; 98954 +STK11 LKB1 Q15831 human PTEN 5728 P60484 PTEN human S380 448313 EPDHyRYsDttDsDP X X 9551; 9554; 9549; 7960 +STK11 LKB1 Q15831 human QSK 70661 Q6P4S6 Sik3 mouse T221 456036 TPGQLLKtWCGsPPY Pkinase X +STK11 LKB1 Q15831 human SMAD4 4089 Q13485 SMAD4 human T77 17478300 kCVTIQRtLDGRLQV MH1 X +STK11 LKB1 Q15831 human NuaK2 81788 Q9H093 NUAK2 human T208 456033 HQGKFLQtFCGSPLY Pkinase X X +STK11 LKB1 Q15831 human SIRT1 23411 Q96EB6 SIRT1 human S615 7998455 GEkNERtsVAGtVRk X X +STK11 LKB1 Q15831 human TORC1 23373 Q6UUV9 CRTC1 human S151 481986 TSWRRtNsDsALHQs TORC_M X 3359 +STK11 LKB1 Q15831 human AMPKA1 65248 P54645 Prkaa1 rat T183 448786 SDGEFLRtsCGSPNY Pkinase X 2535; 2531; 4188; 5256; 50081; 74281 +STK11 LKB1 Q15831 human NuaK1 9891 O60285 NUAK1 human T211 456032 QKDKFLQtFCGSPLY Pkinase X X +STK11 LKB1 Q15831 human AMPKA1 105787 Q5EG47 Prkaa1 mouse T183 448786 sDGEFLRtsCGsPNY Pkinase X X 2535; 2531; 4188; 5256; 50081; 74281 +STK11 LKB1 Q15831 human MELK 9833 Q14680 MELK human T167 456039 NkDyHLQtCCGsLAY Pkinase X +STK11 LKB1 Q15831 human AMPKA1 5562 Q13131 PRKAA1 human T183 448786 sDGEFLRtsCGsPNy Pkinase X X 2535; 2531; 4188; 5256; 50081; 74281 +STK11 LKB1 Q15831 human MARK4 57787 Q96L34 MARK4 human T214 456038 TLGSKLDtFCGsPPY Pkinase X X +STK11 LKB1 Q15831 human BRSK2 9024 Q8IWQ3 BRSK2 human T174 456031 VGDSLLEtSCGSPHY Pkinase X +STK11 LKB1 Q15831 human SIRT1 23411 Q96EB6 SIRT1 human S732 1874020214 EAINEAIsVkQEVTD X X +STK11 LKB1 Q15831 human p53 7157 P04637 TP53 human S392 447535 FktEGPDsD______ X X 9281 +STK11 LKB1 Q15831 human YAP1 iso2 10413 P46937-2 YAP1 human S127 448847 PQHVRAHssPASLQL X 57706 +STK11 LKB1 Q15831 human QIK 23235 Q9H0K1 SIK2 human T175 456035 kSGELLAtWCGSPPY Pkinase X X +STK11 LKB1 Q15831 human MARK2 2011 Q7KZI7 MARK2 human T208 449999 tFGNKLDtFCGsPPY Pkinase X X 4836 +STK11 LKB1 Q15831 human LKB1 6794 Q15831 STK11 human T363 448151 IEDDIIYtQDFTVPG X +STK11 LKB1 Q15831 human AMPKA2 108079 Q8BRK8 Prkaa2 mouse T172 448026 sDGEFLRtsCGsPNY Pkinase X 2535; 2531; 5256; 50081; 74281 +STK11 LKB1 Q15831 human LKB1 6794 Q15831 STK11 human T185 11454701 kPGNLLLtTGGtLKI Pkinase X +STK11 LKB1 Q15831 human PRMT5 10419 O14744 PRMT5 human T132 1267669103 PLNQEDNtNLARVLt PRMT5_TIM X +STK11 LKB1 Q15831 human LKB1 6794 Q15831 STK11 human T189 448149 LLLtTGGtLKISDLG Pkinase X 3054 +STK11 LKB1 Q15831 human MARK3 4140 P27448 MARK3 human T211 450314 TVGGKLDtFCGsPPY Pkinase X X 4836 +STK11 LKB1 Q15831 human SIK 59329 Q9R1U5 Sik1 rat T182 456034 KPGEPLStWCGsPPY Pkinase X +STK11 LKB1 Q15831 human MBP 100344447 P25274 MBP rabbit T65 451757 KDHAARTtHYGSLPQ Myelin_MBP X +STK11 LKB1 Q15831 human STRAD 92335 Q7RTN6 STRADA human T329 11454703 GLSDSLTtSTPRPSN Pkinase X +STK11 LKB1 Q15831 human MARK3 4140 P27448 MARK3 human S215 450315 KLDtFCGsPPYAAPE Pkinase X +STK11 LKB1 Q15831 human BRSK1 iso2 84446 Q8TDC3-2 BRSK1 human T205 456027 VGDSLLEtSCGsPHY Pkinase X +STK11 LKB1 Q15831 human LKB1 6794 Q15831 STK11 human S428 448147 SSkIRRLsACkQQ__ X 3482 +STK11 LKB1 Q15831 human SIK 150094 P57059 SIK1 human T182 456034 kSGEPLStWCGSPPY Pkinase X X +STK11 LKB1 Q15831 human PRMT5 10419 O14744 PRMT5 human T144 1267669104 VLtNHIHtGHHSSMF PRMT5_TIM X X +STK11 LKB1 Q15831 human PAK1 5058 Q13153 PAK1 human T109 14150103 QWARLLQtsNITKsE PBD X +STK11 LKB1 Q15831 human LKB1 6794 Q15831 STK11 human T402 11454702 TEAAQLstKsRAEGR X +STK11 LKB1 Q15831 human hnRNP I iso1 5725 P26599-1 PTBP1 human T138 18010516 sNHkELktDssPNQA RRM_5 X X +STK11 LKB1 Q15831 human BRSK1 84446 Q8TDC3 BRSK1 human T189 456027 VGDSLLEtSCGSPHY Pkinase X +STK11 LKB1 Q15831 human p21Cip1 1026 P38936 CDKN1A human T80 36528801 LPkLYLPtGPRRGRD X X +STK11 LKB1 Q15831 human QSK 23387 Q9Y2K2 SIK3 human T221 456036 TPGQLLKtWCGSPPY Pkinase X X +STK11 LKB1 Q15831 human LKB1 6794 Q15831 STK11 human T336 448150 KDRWRsMtVVPYLED X +STK11 LKB1 Q15831 human SIRT1 23411 Q96EB6 SIRT1 human S669 1874020212 EDDVLSSsSCGSNSD X X +STK11 LKB1 Q15831 human PRMT5 10419 O14744 PRMT5 human T139 1267669102 tNLARVLtNHIHtGH PRMT5_TIM X X +STK11 LKB1 Q15831 human MARK1 4139 Q9P0L2 MARK1 human T215 456037 TVGNKLDtFCGsPPY Pkinase X X 4836 +STK11 LKB1 Q15831 human AMPKA2 5563 P54646 PRKAA2 human T172 448026 sDGEFLRtsCGsPNy Pkinase X X 2535; 2531; 5256; 50081; 74281 +STK11 LKB1 Q15831 human STRAD 92335 Q7RTN6 STRADA human T419 11454704 SGIFGLVtNLEELEV X +STK11 LKB1 Q15831 human p53 7157 P04637 TP53 human S15 447490 PsVEPPLsQEtFsDL P53_TAD X X 4030; 9235; 9284; 9286; 8695; 8514; 82530; 56979 +STK11 LKB1 Q15831 human PTEN 5728 P60484 PTEN human T383 448315 HyRYsDttDsDPENE X X 9554; 9549; 7960 +STK11 LKB1 Q15831 human SNRK 54861 Q9NRH2 SNRK human T173 456502 QPGKKLttsCGSLAY Pkinase X +STK11 LKB1 Q15831 human PTEN 5728 P60484 PTEN human T382 448314 DHyRYsDttDsDPEN X X 9554; 9549; 7960 +aurka AurA Q91820 frog KIF2C 380006 Q91636 kif2c frog S196 2132102 NNQGRRKsNIVKEME X +aurka AurA Q91820 frog KIF2C 380006 Q91636 kif2c frog S719 3545002 LQVEEQAsKQISKKK X +Sik2 QIK Q8CFH6 mouse CDK5R1 12569 P61809 Cdk5r1 mouse S91 12607404 ENLKKSLsCANLSTF X +Sik2 QIK Q8CFH6 mouse IRS1 3667 P35568 IRS1 human S794 447557 QHLRLSTsSGRLLyA X X 2389 +Sik2 QIK Q8CFH6 mouse IRS1 25467 P35570 Irs1 rat S789 447557 QHLRLSSsSGRLRYT X X 2389 +Sik2 QIK Q8CFH6 mouse TORC2 74343 Q3U182 Crtc2 mouse S171 454622 sALNRtSsDsALHTs TORC_M X +CAMK2D CAMK2D iso8 Q13557-8 human TPD52 7163 P55327 TPD52 human S176 465974 kNsPtFksFEEkVEN TPD52 X X +MARK1 MARK1 Q9P0L2 human Tau iso8 4137 P10636-8 MAPT human T231 449079 KKVAVVRtPPKsPss X 20473; 71429 +MARK1 MARK1 Q9P0L2 human Tau iso8 4137 P10636-8 MAPT human S320 450139 VDLskVtskCGsLGN Tubulin-binding X +MARK1 MARK1 Q9P0L2 human Tau iso8 4137 P10636-8 MAPT human S396 449081 GAEIVyKsPVVsGDt X 9632 +MARK1 MARK1 Q9P0L2 human Tau iso8 4137 P10636-8 MAPT human S262 447930 NVKskIGstENLkHQ Tubulin-binding X X +MARK1 MARK1 Q9P0L2 human Tau iso8 4137 P10636-8 MAPT human S324 449328 kVtskCGsLGNIHHk Tubulin-binding X +MARK1 MARK1 Q9P0L2 human Tau iso8 4137 P10636-8 MAPT human S293 449327 NVQskCGsKDNIkHV Tubulin-binding X +MARK1 MARK1 Q9P0L2 human TNK1 8711 Q13470 TNK1 human S502 483166 RMKGIsRsLEsVLsL X +MARK1 MARK1 Q9P0L2 human DIXDC1 iso2 85458 Q155Q3-2 DIXDC1 human S381 23099075 SKLPHSQsSPTVSST X +MARK1 MARK1 Q9P0L2 human Tau iso8 4137 P10636-8 MAPT human S356 449104 rVQskIGsLDNItHV Tubulin-binding X +MARK1 MARK1 Q9P0L2 human FEZ1 9638 Q99689 FEZ1 human S58 454522 SEIISFKsMEDLVNE FEZ X X +MARK1 MARK1 Q9P0L2 human DIXDC1 85458 Q155Q3 DIXDC1 human S592 23099075 SKLPHsQssPTVSST X +MARK1 MARK1 Q9P0L2 human Doublecortin 13193 O88809 Dcx mouse S47 451112 TRTLQALsNEKKAKK X +MARK1 MARK1 Q9P0L2 human Tau iso8 4137 P10636-8 MAPT human S422 449083 GsIDMVDsPQLAtLA X +MARK1 MARK1 Q9P0L2 human Tau iso8 4137 P10636-8 MAPT human S305 487457 kHVPGGGsVQIVykP Tubulin-binding X +GRK7 GRK7 Q8WTQ7 human occludin 100506658 Q16625 OCLN human S471 6094301 LDDyREEsEEyMAAA Occludin_ELL X +Rps6ka2 RSK3 F1M7N7 rat BSN 12217 O88737 Bsn mouse S2860 456576 KTLQRsLsDPKPLsP X +Rps6ka2 RSK3 F1M7N7 rat BSN 29138 O88778 Bsn rat S2845 456576 KTLQRSLsDPKPLSP X +PKDCC PKDCC Q504Y2 human PKDCC 106522 Q5RJI4 Pkdcc mouse Y148 26375901 AQYVGSGyTKAVYRV X +PKDCC PKDCC Q504Y2 human PKDCC 106522 Q5RJI4 Pkdcc mouse S177 26375900 FSGHDLGsCVREFGA X +PKDCC PKDCC Q504Y2 human HDAC5 84580 F1LM64 Hdac5 rat S322 447996 RPLSRTQsSPLPQSP X +PKDCC PKDCC Q504Y2 human HDAC5 84580 F1LM64 Hdac5 rat S83 447995 FPLRKTAsEPNLKVR X +PHKA1 PHKA1 P46020 human PYGB 5834 P11216 PYGB human S15 456885 sEkRKQIsVRGLAGL X +Prkci PKCI F1M7Y5 rat ATP1A1 24211 P06685 Atp1a1 rat S16 449086 KyEPAAVsEHGDkks X 4020 +Prkci PKCI F1M7Y5 rat MARK2 60328 O08679 Mark2 rat T539 453427 RGVSSRStFHAGQLR X +Prkci PKCI F1M7Y5 rat ATP1A1 24211 P06685 Atp1a1 rat S23 449087 sEHGDkkskkAKKER X 4006 +Yes1 Yes F1LM93 rat Yes 24884 F1LM93 Yes1 rat Y424 447619 RLIEDNEyTARQGAk PK_Tyr_Ser-Thr X 2101; 6943; 59548; 70926; 78740; 94361; 17320 +Yes1 Yes F1LM93 rat Yes 24884 F1LM93 Yes1 rat Y32 454273 VNTSAGHyGVEHATA X +ULK3 ULK3 Q6PHR2 human ULK3 25989 Q6PHR2 ULK3 human S300 26395102 KKDQEGDsAAALsLY MIT X +ULK3 ULK3 Q6PHR2 human ULK3 25989 Q6PHR2 ULK3 human S350 26395101 ELkAIVSsSNQALLR X +ULK3 ULK3 Q6PHR2 human ULK3 25989 Q6PHR2 ULK3 human S464 19084302 DkEGLSEsVRSSCTL X +ULK3 ULK3 Q6PHR2 human ULK3 25989 Q6PHR2 ULK3 human S384 26395100 LAALEVAsAAMAKEE MIT X +ULK3 ULK3 Q6PHR2 human PIK3C3 5289 Q8NEB9 PIK3C3 human S249 35483209 ESsPILTsFELVKVP X 13857 +SGK2 SGK2 Q9HBY8 human PTOV1 53635 Q86YD1 PTOV1 human S53 4767655 PPRIRARsAPPMEGA X +SGK2 SGK2 Q9HBY8 human PTOV1 53635 Q86YD1 PTOV1 human S36 11138413 VRAVRsRsWPAsPRG X X +SGK2 SGK2 Q9HBY8 human L-plastin 3936 P13796 LCP1 human S5 450852 ___MARGsVsDEEMM X +SGK2 SGK2 Q9HBY8 human MDM2 4193 Q00987 MDM2 human S166 448130 SsRRRAIsEtEENsD X 3521 +PKN2 PKN2 Q16513 human eNOS 4846 P29474 NOS3 human S1179 467802 RIRtQsFsLQERQLR X X +PKN2 PKN2 Q16513 human pyrin 4210 O15553 MEFV human S208 455897 VRLRRNAssAGRLQG X +PKN2 PKN2 Q16513 human pyrin 4210 O15553 MEFV human S242 455899 SGKMRPRsLEVTIST X +pYV0094 yopH P08538 bacteria Lck 3932 P06239 LCK human Y394 447822 RLIEDNEytAREGAk PK_Tyr_Ser-Thr X 2101; 6943; 59548; 70926; 78740; 94361; 17320 +Akt1 Akt1 P47196 rat GSK3B 84027 P18266 Gsk3b rat S9 449111 SGRPRTTsFAESCKP X 9336; 9331; 9327; 9323; 9322; 9325; 5558; 8566; 79774; 8466; 25462; 14026; 14332; 14310; 14630 +Akt1 Akt1 P47196 rat FOXO1A 84482 G3V7R4 Foxo1 rat T24 448560 LPRQRSCtWPLPRPE X 9464 +Akt1 Akt1 P47196 rat Merlin 4771 P35240 NF2 human S315 487469 MRRRKADsLEVQQMk FERM_C X +Akt1 Akt1 P47196 rat acinus 305884 E9PST5 Acin1 rat S1180 456759 GPRSRSRsRDRRRKE RSB_motif X +Akt1 Akt1 P47196 rat IRS1 25467 P35570 Irs1 rat S522 447561 RFRKRTHsAGtsPTI X +Akt1 Akt1 P47196 rat FOXO1A 84482 G3V7R4 Foxo1 rat S313 449113 TFRPRTSsNAsTIsG X 2486 +Akt1 Akt1 P47196 rat S6 29304 P62755 Rps6 rat S235 448092 IAKRRRLssLRAsts X 5006; 4856; 4857; 4858; 4851; 4803; 2211; 3945; 3985; 5316; 4854; 8520; 48319; 40643; 9865; 38573; 14733; 27036; 34411; 62016; 62788; 81736; 97935; 99457; 15448 +Akt1 Akt1 P47196 rat PRPF19 27339 Q9UMS4 PRPF19 human T193 17331800 ERKKRGktVPEELVk X +Akt1 Akt1 P47196 rat eNOS 24600 Q62600 Nos3 rat S1176 447884 TSRIRtQsFsLQERQ X 9570 +Akt1 Akt1 P47196 rat AMPKA1 65248 P54645 Prkaa1 rat S496 450431 AtPQRSGsISNYRSC AdenylateSensor X 4185; 4184; 2537 +Akt1 Akt1 P47196 rat FOXO1A 84482 G3V7R4 Foxo1 rat S250 448075 sPRRRAAsMDNNSkF X 9461; 84192 +Akt1 Akt1 P47196 rat BAD 64639 O35147 Bad rat S137 447862 PFRGRsRsAPPNLWA Bcl-2_BAD X 9295; 5286; 4366 +Akt1 Akt1 P47196 rat RAF1 24703 P11345 Raf1 rat S259 447741 SQRQRSTsTPNVHMV X 9421; 20011 +Akt1 Akt1 P47196 rat Bcl-xL 24888 P53563 Bcl2l1 rat S106 5014911 LRYRRAFsDLTSQLH Bcl-2 X +Akt1 Akt1 P47196 rat FOXO3A 294515 D3ZBQ1 Foxo3 rat S252 449108 APRRRAVsMDNSNkY X 9466; 13129 +Akt1 Akt1 P47196 rat RPS3 6188 P23396 RPS3 human T70 15113600 GrrIrELtAVVQkRF KH_2 X +Akt1 Akt1 P47196 rat Merlin 4771 P35240 NF2 human T230 487468 AIRNKKGtELLLGVD FERM_C X +Akt1 Akt1 P47196 rat FOXO3A 2309 O43524 FOXO3 human T32 448602 QsRPRsCtWPLQRPE X 2599; 9464 +Akt1 Akt1 P47196 rat AMPKA2 78975 Q09137 Prkaa2 rat S491 450432 StPQRSCsAAGLHRP AdenylateSensor X 4185 +Akt1 Akt1 P47196 rat PRAS40 292887 D3ZH75 Akt1s1 rat T247 470067 LPRPRLNtSDFQKLK PRAS X 2640; 2997; 32263; 13175; 60202 +Akt1 Akt1 P47196 rat S6 29304 P62755 Rps6 rat S236 448093 AKRRRLssLRAstsK X 5006; 4856; 4857; 4858; 4851; 4803; 2211; 3945; 3985; 5316; 4854; 8520; 48319; 40643; 9865; 38573; 14733; 27036; 34411; 62016; 62788; 81736; 97935; 99457; 15448 +Akt1 Akt1 P47196 rat FOXO3A 294515 D3ZBQ1 Foxo3 rat T32 448602 QSRPRSCtWPLQRPE X 9464 +Akt1 Akt1 P47196 rat lamin A/C 60374 P48679 Lmna rat S404 478681 RSRGRAssHssQSQG X +Akt1 Akt1 P47196 rat FOXO3A 2309 O43524 FOXO3 human S253 449108 APRRRAVsMDNSNkY X 9466; 13129 +Akt1 Akt1 P47196 rat PLB 64672 P61016 Pln rat S16 448114 RSAIRRAstIEMPQQ Phospholamban X 8496 +MARK2 MARK2 Q7KZI7 human PAR3-alpha 81918 Q9Z340 Pard3 rat S852 1983958 VKTRKSKsMDLGIAD X X +MARK2 MARK2 Q7KZI7 human KIF13B 23303 Q9NQT8 KIF13B human S1410 482224 SNKGRWEsQQDVsQT X X +MARK2 MARK2 Q7KZI7 human ARHGEF2 9181 Q92974 ARHGEF2 human S186 1220712 NMRNRtLsVEsLIDE X X +MARK2 MARK2 Q7KZI7 human RAB11FIP2 22841 Q7L804 RAB11FIP2 human S227 465674 QRLsSAHsMsDLSGS X X +MARK2 MARK2 Q7KZI7 human KCNK18 332396 Q6VV64 Kcnk18 mouse S279 13383301 RLsCsILsNLDEVGQ X +MARK2 MARK2 Q7KZI7 human PAR3-alpha 81918 Q9Z340 Pard3 rat S144 455668 PLHVRRssDPALtGL X +MARK2 MARK2 Q7KZI7 human Tau iso8 4137 P10636-8 MAPT human S262 447930 NVKskIGstENLkHQ Tubulin-binding X X +MARK2 MARK2 Q7KZI7 human HDAC4 9759 P56524 HDAC4 human S467 448489 RPLGRtQsAPLPQNA X +MARK2 MARK2 Q7KZI7 human Tau iso8 4137 P10636-8 MAPT human S324 449328 kVtskCGsLGNIHHk Tubulin-binding X +MARK2 MARK2 Q7KZI7 human PSD-95 1742 P78352 DLG4 human S561 25680400 EFPDKFGsCVPHTTR Guanylate_kin X X +MARK2 MARK2 Q7KZI7 human MST2 6788 Q13188 STK3 human S15 4272103 KSKLKkLsEDsLTkQ X X +MARK2 MARK2 Q7KZI7 human ARHGEF2 iso2 9181 Q92974-2 ARHGEF2 human S885 451365 PVDPRRRsLPAGDAL X X 14143 +MARK2 MARK2 Q7KZI7 human PINK1 65018 Q9BXM7 PINK1 human T313 23003808 EGLGHGRtLFLVMkN Pkinase X X +MARK2 MARK2 Q7KZI7 human utrophin 7402 P46939 UTRN human S1258 2525745 TLEERMKsTEVLPEk X X +MARK2 MARK2 Q7KZI7 human ARHGEF2 9181 Q92974 ARHGEF2 human S143 10991696 GsRRGRssLsLAksV X X +MARK2 MARK2 Q7KZI7 human RAB11FIP1 iso3 80223 Q6WKZ4-3 RAB11FIP1 human S234 4691719 QKTPLSQsMSVLPTS X X +MARK2 MARK2 Q7KZI7 human HDAC7 51564 Q8WUI4 HDAC7 human S155 455620 FPLRKtVsEPNLkLR X 3443 +MARK2 MARK2 Q7KZI7 human HDAC4 9759 P56524 HDAC4 human S246 448488 FPLRkTAsEPNLKLR X X 3443 +MARK2 MARK2 Q7KZI7 human PAR3-alpha 56288 Q8TEW0 PARD3 human S873 3207429 VDDQKAGsPsRDVGP X +MARK2 MARK2 Q7KZI7 human MARK2 2011 Q7KZI7 MARK2 human S400 5635600 HkVQRsVsANPKQRR X +MARK2 MARK2 Q7KZI7 human FAK 5747 Q05397 PTK2 human Y397 447887 sVsEtDDyAEIIDEE X 3283; 8556 +MARK2 MARK2 Q7KZI7 human ARHGEF2 iso2 9181 Q92974-2 ARHGEF2 human S959 467500 SRLSPPHsPRDFTRM X +MARK2 MARK2 Q7KZI7 human Tau iso8 4137 P10636-8 MAPT human S356 449104 rVQskIGsLDNItHV Tubulin-binding X +MARK2 MARK2 Q7KZI7 human TORC2 74343 Q3U182 Crtc2 mouse S171 454622 sALNRtSsDsALHTs TORC_M X +MARK2 MARK2 Q7KZI7 human FEZ1 9638 Q99689 FEZ1 human S58 454522 SEIISFKsMEDLVNE FEZ X X +MARK2 MARK2 Q7KZI7 human RNF41 10193 Q9H4P4 RNF41 human S254 29675602 IENAHERsWPQGLAT USP8_interact X +MARK2 MARK2 Q7KZI7 human MRLC1 10398 P24844 MYL9 human S20 1863500 KRPQRAtsNVFAMFD X X 3674; 3671; 3675; 95777 +MARK2 MARK2 Q7KZI7 human IRSp53 10458 Q9UQB8 BAIAP2 human S366 468035 ktLPRsssMAAGLER X +MARK2 MARK2 Q7KZI7 human KCNK18 332396 Q6VV64 Kcnk18 mouse S274 13383300 ELVLGRLsCsILsNL X X +MARK2 MARK2 Q7KZI7 human ARHGEF2 9181 Q92974 ARHGEF2 human S172 460815 LGLRRILsQstDsLN X X +MARK2 MARK2 Q7KZI7 human HDAC5 10014 Q9UQL6 HDAC5 human S259 447995 FPLRkTAsEPNLKVR X 3443 +MARK2 MARK2 Q7KZI7 human PAR3-alpha 56288 Q8TEW0 PARD3 human S144 455668 PLHVRRssDPALIGL X +MARK2 MARK2 Q7KZI7 human KCNK18 332396 Q6VV64 Kcnk18 mouse S276 12525800 VLGRLsCsILsNLDE X X +MARK2 MARK2 Q7KZI7 human Tau 17762 P10637 Mapt mouse S554 447930 NVRSkIGstENLKHQ Tubulin-binding X +MARK2 MARK2 Q7KZI7 human TORC2 74343 Q3U182 Crtc2 mouse S275 3174300 PAMNTGGsLPDLTNL TORC_M X X +MARK2 MARK2 Q7KZI7 human eIF2-alpha 1965 P05198 EIF2S1 human S52 447635 MILLsELsRRRIRsI S1 X X 3597; 9721; 3398; 5199; 53085; 95797 +MARK2 MARK2 Q7KZI7 human TORC2 74343 Q3U182 Crtc2 mouse S307 454633 PSLSGGNsTTNLTHT TORC_M X +MARK2 MARK2 Q7KZI7 human KIF13B 23303 Q9NQT8 KIF13B human S1381 4691956 KLSRRsIssPNVNRL X X +Camk4 CAMK4 P13234 rat QIK 315649 Q3LRT3 Sik2 rat T484 478056 RSGQRRHtLSEVTNQ X +Camk4 CAMK4 P13234 rat Calmodulin 24242 P0DP29 Calm3 rat T45 469598 RSLGQNPtEAELQDM EF-hand_7 X +Camk4 CAMK4 P13234 rat NUMB 8650 P49757 NUMB human S276 456490 EQLARQGsFrGFPAL NumbF X 4140; 9878 +Camk4 CAMK4 P13234 rat ADCY1 281601 P19754 ADCY1 cow S552 451156 sEKLRNRsSFSTNVV X +Camk4 CAMK4 P13234 rat CAMK4 25050 P13234 Camk4 rat S437 451566 DQEMKRNsEETLKsV X +Camk4 CAMK4 P13234 rat ADCY1 281601 P19754 ADCY1 cow S545 451155 RRALRTAsEKLRNRs X +Camk4 CAMK4 P13234 rat NUMBL 292732 A1L1I3 Numbl rat S305 456489 EQLVRQGsFRGFPAL NumbF X +CLK2 CLK2 P49760 human PPP2R5B 225849 Q6PD28 Ppp2r5b mouse S32 31895400 PDKVDGFsRRsLRRA X X +CLK2 CLK2 P49760 human PAGE4 9506 O60829 PAGE4 human S7 63280104 _MSARVRsRsRGrGD GAGE X +CLK2 CLK2 P49760 human CK1D 64462 Q06486 Csnk1d rat S370 483997 MERERKVsMRLHRGA X +CLK2 CLK2 P49760 human PAGE4 9506 O60829 PAGE4 human S73 63280106 MDLEKtRsERGDGsD GAGE X +CLK2 CLK2 P49760 human PPP2R5B 225849 Q6PD28 Ppp2r5b mouse S48 23134678 PRRsHsssQFRyQSN X X +CLK2 CLK2 P49760 human PPP2R5B 225849 Q6PD28 Ppp2r5b mouse S46 18261152 ARPRRsHsssQFRyQ X X +CLK2 CLK2 P49760 human PTP1B 5770 P18031 PTPN1 human S243 9921201 DKRkDPssVDIkKVL Y_phosphatase X +CLK2 CLK2 P49760 human PAGE4 9506 O60829 PAGE4 human S79 63280102 RsERGDGsDVKEKtP GAGE X +CLK2 CLK2 P49760 human PAGE4 9506 O60829 PAGE4 human T71 63280103 QEMDLEKtRsERGDG GAGE X +CLK2 CLK2 P49760 human PPP2R5B 225849 Q6PD28 Ppp2r5b mouse S44 10405463 RRARPRRsHsssQFR X X +CLK2 CLK2 P49760 human PAGE4 9506 O60829 PAGE4 human T85 15421970 GsDVKEKtPPNPKHA GAGE X +CLK2 CLK2 P49760 human PTP1B 5770 P18031 PTPN1 human S50 447811 RNRyRDVsPFDHsRI Y_phosphatase X +CLK2 CLK2 P49760 human PAGE4 9506 O60829 PAGE4 human T94 63280105 PNPKHAKtKEAGDGQ GAGE X +CLK2 CLK2 P49760 human PAGE4 9506 O60829 PAGE4 human T51 3913886 PGQEREGtPPIEERK GAGE X +CLK2 CLK2 P49760 human PAGE4 9506 O60829 PAGE4 human S9 63280101 SARVRsRsRGrGDGQ GAGE X +CLK2 CLK2 P49760 human PPP2R5B 225849 Q6PD28 Ppp2r5b mouse S47 10405468 RPRRsHsssQFRyQS X X +CLK2 CLK2 P49760 human PTP1B 5770 P18031 PTPN1 human S242 9921200 MDKRkDPssVDIkKV Y_phosphatase X +CLK2 CLK2 P49760 human PPP2R5B 225849 Q6PD28 Ppp2r5b mouse S35 10405458 VDGFsRRsLRRARPR X X +Lrrk2 LRRK2 Q5S006 mouse RAB12 19328 P35283 Rab12 mouse S105 487152 AGQERFNsITSAYYR Ras X +Lrrk2 LRRK2 Q5S006 mouse RAB10 19325 P61027 Rab10 mouse T73 471953 AGQERFHtITTSYYR Ras X +Lrrk2 LRRK2 Q5S006 mouse SYN1 24949 P09951 Syn1 rat T339 2020533 sGNWKtNtGsAMLEQ Synapsin_C X +Lrrk2 LRRK2 Q5S006 mouse SYN1 24949 P09951 Syn1 rat T337 486180 SVsGNWKtNtGsAML Synapsin_C X +Akt3 Akt3 Q63484 rat GJA1 24392 P08050 Gja1 rat S373 459209 RAssRAssRPRPDDL X +BAZ1B WSTF Q9UIG0 human H2AX 3014 P16104 H2AX human Y142 3397700 AtQAsQEy_______ X 5438 +BAZ1B WSTF Q9UIG0 human H2AX 15270 P27661 H2ax mouse Y142 3397700 AsQAsQEy_______ X 5438 +SGK1 SGK1 O00141 human NHE3 100009430 P26432 NHE-3 rabbit S663 457469 TMRKRLEsFKSAKLG X +SGK1 SGK1 O00141 human NEDD4L 23327 Q96PU5 NEDD4L human S342 453438 ssRLRsCsVtDAVAE X X 12146 +SGK1 SGK1 O00141 human AS160 9882 O60343 TBC1D4 human S318 455925 EFRsRCssVtGVQRR PID X 8619 +SGK1 SGK1 O00141 human SHANK2 iso7 171093 Q9QX74-7 Shank2 rat S477 33668500 GPRSRSPsLNRLGGA X +SGK1 SGK1 O00141 human NDRG2 57447 Q9UN36 NDRG2 human T330 454243 tRLsRsRtAsLtsAA X X +SGK1 SGK1 O00141 human AMPKA2 108079 Q8BRK8 Prkaa2 mouse S491 450432 stPQRSCsAAGLHRA AdenylateSensor X X +SGK1 SGK1 O00141 human NEDD4L 83814 Q8CFI0 Nedd4l mouse S371 453438 sSRLRsCsVTDTVAE X 12146 +SGK1 SGK1 O00141 human TRPV4 63873 Q9EPK8 Trpv4 mouse S824 4777181 LRRDRWssVVPRVVE X +SGK1 SGK1 O00141 human Fe65 29722 P46933 Apbb1 rat S611 2035401 ECRVRFLsFLAVGRD PID X +SGK1 SGK1 O00141 human nicastrin 23385 Q92542 NCSTN human S437 25533000 FLRArNIsGVVLADH Nicastrin X +SGK1 SGK1 O00141 human NDRG2 57447 Q9UN36 NDRG2 human S346 454244 VDGNRsRsRtLsQss X +SGK1 SGK1 O00141 human p27Kip1 1027 P46527 CDKN1B human T157 448645 GIRkrPAtDDSSTQN X X +SGK1 SGK1 O00141 human MLL4 iso3 8085 O14686-3 KMT2D human S1331 1217705 RGRARLKsTASSIET X X +SGK1 SGK1 O00141 human ELK1 314436 A4GTP4 Elk1 rat S159 2028400 YMRSGLYstFTIQSL X X +SGK1 SGK1 O00141 human SRF 501099 D3ZHH8 Srf rat S99 447692 RGLKRSLsEMELGVV X +SGK1 SGK1 O00141 human NLRP3 216799 Q8R4B8 Nlrp3 mouse S3 38492201 _____MTsVRCKLAQ X +SGK1 SGK1 O00141 human NEDD4L 83814 Q8CFI0 Nedd4l mouse S477 453440 IRRPRsLssPtVtLS X 8063 +SGK1 SGK1 O00141 human Mnk1 iso2 8569 Q9BUB5-2 MKNK1 human S353 56790200 QVLQRNSsTMDLTLF X +SGK1 SGK1 O00141 human GSK3B 2932 P49841 GSK3B human Y216 448569 RGEPNVsyICsRyyR Pkinase X X +SGK1 SGK1 O00141 human FOXO3A 2309 O43524 FOXO3 human S315 449109 DFRsRTNsNAstVsG X +SGK1 SGK1 O00141 human NEDD4L 23327 Q96PU5 NEDD4L human S448 453440 IRRPRsLssPtVtLS X X 8063 +SGK1 SGK1 O00141 human ERK2 5594 P28482 MAPK1 human S29 7989100 GPRyTNLsYIGEGAy Pkinase X +SGK1 SGK1 O00141 human CREB iso1 81646 P15337-1 Creb1 rat S133 448228 EILsRRPsYRkILND pKID X X 9187; 9196; 9198; 4095; 14228; 14001; 39561; 80120; 44864; 54960; 95995 +SGK1 SGK1 O00141 human TSC2 7249 P49815 TSC2 human S981 454014 AFRCRSIsVSEHVVR X X +SGK1 SGK1 O00141 human MEKK3 26406 Q61084 Map3k3 mouse S166 3188100 EPRSRHLsVsSQNPG X X +SGK1 SGK1 O00141 human AS160 9882 O60343 TBC1D4 human S570 455923 AKRsLtssLENIFsr X +SGK1 SGK1 O00141 human MKK4 6416 P45985 MAP2K4 human S80 447655 IERLRtHsIESSGkL X 9155 +SGK1 SGK1 O00141 human TSC2 7249 P49815 TSC2 human S1130 448499 GARDRVRsMsGGHGL X X +SGK1 SGK1 O00141 human WNK4 65266 Q96J92 WNK4 human S1190 477191 SSRQRRLsKGSFPTS X X +SGK1 SGK1 O00141 human NDRG1 10397 Q92597 NDRG1 human T366 454246 GtRsRsHtsEGAHLD X X +SGK1 SGK1 O00141 human Tau 29477 P19332 Mapt rat S525 447929 GsRSRtPsLPtPPTR X 77348 +SGK1 SGK1 O00141 human Huntingtin 3064 P42858 HTT human S419 448106 GGRsRsGsIVELIAG X X +SGK1 SGK1 O00141 human ELK1 314436 A4GTP4 Elk1 rat T160 2028401 MRSGLYstFTIQSLQ X X +SGK1 SGK1 O00141 human FBXW7 55294 Q969H0 FBXW7 human S227 17792400 QQRRRITsVQPPTGL X X +SGK1 SGK1 O00141 human ENaC-alpha 25122 P37089 Scnn1a rat S621 454020 RFRsRYWsPGRGARG X +SGK1 SGK1 O00141 human IkB-alpha 4792 P25963 NFKBIA human S32 448203 LLDDRHDsGLDsMkD X 5210; 2859; 9246; 5209 +SGK1 SGK1 O00141 human MEKK3 26406 Q61084 Map3k3 mouse S337 468184 DPRGRLRsADsENAL X X +SGK1 SGK1 O00141 human Fe65 322 O00213 APBB1 human S610 2035401 ECRVRFLsFLAVGRD PID X +SGK1 SGK1 O00141 human NDRG1 10397 Q92597 NDRG1 human T346 454245 GtRsRsHtsEGtRsR X X 3217; 5482; 6992; 7497; 8947; 89166 +SGK1 SGK1 O00141 human NDRG1 10397 Q92597 NDRG1 human T356 454247 GtRsRsHtsEGtRsR X X +SGK1 SGK1 O00141 human TSC2 7249 P49815 TSC2 human T1462 448546 GLrPrGytISDsAPs X X 3617; 3611 +SGK1 SGK1 O00141 human NDRG2 57447 Q9UN36 NDRG2 human T348 451009 GNRsRsRtLsQssEs X X +SGK1 SGK1 O00141 human CREB 1385 P16220 CREB1 human S119 448228 EILsRRPsyRkILND pKID X 9187; 9196; 9198; 4095; 14228; 14001; 39561; 80120; 44864; 54960; 95995 +SGK1 SGK1 O00141 human NEDD4L 23327 Q96PU5 NEDD4L human T367 453439 AGRARsstVtGGEEP X +SGK1 SGK1 O00141 human TSC2 7249 P49815 TSC2 human S939 448501 sFRARstsLNERPKs X X 3615 +SGK1 SGK1 O00141 human GSK3B 2932 P49841 GSK3B human S9 449111 SGRPRttsFAEsCkP X 9336; 9331; 9327; 9323; 9322; 9325; 5558; 8566; 79774; 8466; 25462; 14026; 14332; 14310; 14630 +SGK1 SGK1 O00141 human Kaiso 10009 Q86T24 ZBTB33 human T606 34353150 yLSDRSStIPAMkDD X +SGK1 SGK1 O00141 human NDRG2 57447 Q9UN36 NDRG2 human S332 451010 LsRsRtAsLtsAAsV X X +SGK1 SGK1 O00141 human AS160 9882 O60343 TBC1D4 human S751 455924 EGRKRtsstCsNEsL X +SGK1 SGK1 O00141 human MDM2 4193 Q00987 MDM2 human S166 448130 SsRRRAIsEtEENsD X 3521 +SGK1 SGK1 O00141 human Tau iso8 4137 P10636-8 MAPT human S214 447929 GsRsRtPsLPtPPtR X X 77348 +SGK1 SGK1 O00141 human AS160 9882 O60343 TBC1D4 human S341 455922 QPRRRHAsAPsHVQP PID X +SGK1 SGK1 O00141 human p27Kip1 1027 P46527 CDKN1B human T198 448781 PGLRRRQt_______ X +SGK1 SGK1 O00141 human TSC2 7249 P49815 TSC2 human S1798 454016 GQRKRLIssVEDFTE X X +SGK1 SGK1 O00141 human SGK1 6446 O00141 SGK1 human S422 448429 AEAFLGFsYAPPTDS Pkinase_C X X +SGK1 SGK1 O00141 human SLC1A6 84012 O35921 Slc1a6 rat T40 480172 RTRLRLQtMTREHVR X +SGK1 SGK1 O00141 human AMPKA2 108079 Q8BRK8 Prkaa2 mouse T485 8090273 EQRsGSstPQRSCsA AdenylateSensor X +SGK1 SGK1 O00141 human CARHSP1 23589 Q9Y2V2 CARHSP1 human S52 453062 tRRtrtFsAtVRAsQ X +SGK1 SGK1 O00141 human WNK1 65125 Q9H4A3 WNK1 human T60 450948 EYRRRRHtMDKDSrG X 4946 +SGK1 SGK1 O00141 human AS160 9882 O60343 TBC1D4 human T642 455921 QFRRRAHtFsHPPss X 4288; 8881 +SGK1 SGK1 O00141 human GLUT4 6517 P14672 SLC2A4 human S274 478418 LERERPLsLLQLLGs Sugar_tr X +SGK1 SGK1 O00141 human NDRG1 10397 Q92597 NDRG1 human S330 452879 LMRsRtAsGssVtsL X X 3506; 11899 +SGK1 SGK1 O00141 human AS160 9882 O60343 TBC1D4 human T568 486326 NKAKRsLtssLENIF X +SGK1 SGK1 O00141 human AS160 9882 O60343 TBC1D4 human S588 455920 RMRGRLGsVDsFERs X 8730 +SGK1 SGK1 O00141 human WNK4 69847 Q80UE6 Wnk4 mouse S1196 5879855 PGIMRRNsLSGSSTG X +SGK1 SGK1 O00141 human GDI1 25183 P50398 Gdi1 rat S213 12607403 INrIkLYsESLARYG GDI X +SGK1 SGK1 O00141 human TSC2 7249 P49815 TSC2 human S1132 448500 RDRVRsMsGGHGLRV X X +SGK1 SGK1 O00141 human NEDD4L 83814 Q8CFI0 Nedd4l mouse T396 453439 TRRARSStVTGGEEP X +SGK1 SGK1 O00141 human AS160 9882 O60343 TBC1D4 human S666 486327 GRAQGVRsPLLRQSS X +SGK1 SGK1 O00141 human WNK4 65266 Q96J92 WNK4 human S1201 23073728 FPTSRRNsLQRSEPP X X +SGK1 SGK1 O00141 human FOXO3A 56484 Q9WVH4 Foxo3 mouse T32 448602 QSRPRSCtWPLQRPE X 9464 +SGK1 SGK1 O00141 human PIKFYVE 200576 Q9Y2I7 PIKFYVE human S318 3216759 LsLDRsGsPMVPSyE X +SGK1 SGK1 O00141 human RICTOR 253260 Q6R327 RICTOR human T1135 458276 NRRIRtLtEPsVDFN RICTOR_phospho X 3806 +SGK1 SGK1 O00141 human IKKB 3551 O14920 IKBKB human S181 447489 DQGsLCtsFVGTLQy Pkinase X 2697; 2694; 14938; 92255; 36516; 36214 +SGK1 SGK1 O00141 human NDRG1 10397 Q92597 NDRG1 human T328 452881 TRLMRsRtAsGssVt X +SGK1 SGK1 O00141 human WNK4 69847 Q80UE6 Wnk4 mouse S1169 477191 SCRQRRLsKGsFPTS X X +SGK1 SGK1 O00141 human WNK4 65266 Q96J92 WNK4 human S1217 5879855 PGIMRRNsLSGSStG X X +Pik3ca PIK3CA P42337 mouse CEACAM1 26365 P31809 Ceacam1 mouse Y515 451429 PRAtETVysEVkKK_ X +JAK1 JAK1 P23458 human SIRT1 23411 Q96EB6 SIRT1 human Y280 25311269 FRSRDGIyARLAVDF SIR2 X +JAK1 JAK1 P23458 human PERK 9451 Q9NZJ5 EIF2AK3 human Y585 35518100 NDIkNSGyISRYLTD X X +JAK1 JAK1 P23458 human HADHA 3030 P40939 HADHA human Y499 55372195 EKVIGMHyFsPVDkM 3HCDH_N X +JAK1 JAK1 P23458 human TRPV2 29465 Q9WUD2 Trpv2 rat Y335 1877505000 RKFTEWCyGPVRVSL X X +JAK1 JAK1 P23458 human STAT5A 6776 P42229 STAT5A human Y694 447767 LAkAVDGyVkPQIkQ X 9365; 9356; 9359; 9351; 4322; 9314; 3939; 40284; 5387; 14603; 66740; 51879; 72712 +JAK1 JAK1 P23458 human HADHA 3030 P40939 HADHA human Y271 1883585000 LVEKLTAyAMTIPFV X +JAK1 JAK1 P23458 human RIPK1 8737 Q13546 RIPK1 human Y384 451864 kLQDEANyHLyGsRM X +JAK1 JAK1 P23458 human TRPV2 29465 Q9WUD2 Trpv2 rat Y471 1877505002 WISFMDSyFEILFLL Ion_trans X +JAK1 JAK1 P23458 human SNX8 29886 Q9Y5X2 SNX8 human Y126 348335701 MLLHkFPyRMVPALP PX X +JAK1 JAK1 P23458 human HADHA 3030 P40939 HADHA human Y435 55372191 NLTGQLDyQGFEKAD 3HCDH_N X +JAK1 JAK1 P23458 human ASK1 4217 Q99683 MAP3K5 human Y718 458209 IPERDSRySQPLHEE Pkinase X +JAK1 JAK1 P23458 human STAT3 20848 P42227 Stat3 mouse Y705 448192 DPGsAAPyLktkFIC X 4093; 9145; 4324; 9131; 9138; 4323; 4074; 4113; 48313; 20977; 25023; 8119; 52075; 52527; 73533; 61958; 73452; 16185; 74309 +JAK1 JAK1 P23458 human H3 8350 P68431 H3C1 human Y41 10897613 GVkkPHryrPGtVAL Histone X +JAK1 JAK1 P23458 human PERK 9451 Q9NZJ5 EIF2AK3 human Y619 1256400 NKVDDCNyAIkRIRL Pkinase X X +JAK1 JAK1 P23458 human STAT5A 20850 P42230 Stat5a mouse Y694 447767 LAKAVDGyVkPQIKQ X 9365; 9356; 9359; 9351; 4322; 9314; 3939; 40284; 5387; 14603; 66740; 51879; 72712 +JAK1 JAK1 P23458 human TRPV2 29465 Q9WUD2 Trpv2 rat Y525 2527084 GFQHTGIySVMIQKV Ion_trans X +JAK1 JAK1 P23458 human SIRT1 23411 Q96EB6 SIRT1 human Y301 25311272 QAMFDIEyFRKDPRP SIR2 X +JAK1 JAK1 P23458 human HADHA 3030 P40939 HADHA human Y43 1883601202 LTRTHINyGVkGDVA X +JAK1 JAK1 P23458 human SNX8 29886 Q9Y5X2 SNX8 human Y95 348335702 LFLKHVEyEVSSQRF X +JAK1 JAK1 P23458 human PD-L1 29126 Q9NZQ7 CD274 human Y112 1015586 KLQDAGVyRCMISYG V-set X X +JAK1 JAK1 P23458 human STAT1 6772 P42224 STAT1 human Y701 447754 DGPkGtGyIktELIs X 9174; 9167; 5375; 25685; 8062; 8183; 8009; 55603; 7649; 25809; 57216; 45118; 39205; 88845; 88211; 76285; 90145 +TAF1 TAF1 P21675 human GTF2A1 2957 P52655 GTF2A1 human S316 448629 VEEEPLNsEDDVsDE TFIIA X X +TAF1 TAF1 P21675 human GTF2A1 2957 P52655 GTF2A1 human S321 448630 LNsEDDVsDEEGQEL TFIIA X X +TAF1 TAF1 P21675 human TAF7 6879 Q15545 TAF7 human S264 468898 LQDKLNEsDEQHQEN X X +TAF1 TAF1 P21675 human p53 7157 P04637 TP53 human T55 450685 DDIEQWFtEDPGPDE TAD2 X X +MASTL MASTL Q96GX5 human ENSA 2029 O43768 ENSA human S67 455934 kGQkyFDsGDyNMAk Endosulfine X 5240 +MASTL MASTL Q96GX5 human ARPP-19 10776 P56211 ARPP19 human S62 465742 kGQkyFDsGDyNMAk Endosulfine X 5240 +Cdk1 CDK1 P39951 rat Caldesmon 25687 Q62736 Cald1 rat T468 448467 SsPSASGtPNKETAG Caldesmon X +Cdk1 CDK1 P39951 rat VCIP135 286761 Q8CF97 Vcpip1 rat S130 40642201 NYHCKLLsPILARYG VCIP135_N X X +Cdk1 CDK1 P39951 rat Caldesmon 25687 Q62736 Cald1 rat S462 448464 EKGSVFSsPSASGtP Caldesmon X +Cdk1 CDK1 P39951 rat Caldesmon 25687 Q62736 Cald1 rat S491 448468 INEWLTksPDGNKsP Caldesmon X +Cdk1 CDK1 P39951 rat NMDAR1 24408 P35439 Grin1 rat S584 1871177708 LYLLDRFsPFGRFKV Lig_chan X X +Cdk1 CDK1 P39951 rat PKLR iso2 24651 P12928-2 Pklr rat S113 31084572 ATESFATsPLSYRPV PK X X +Cdk1 CDK1 P39951 rat Src 396442 P00523 SRC chicken T34 455775 GGFPASQtPNKTAAP X +Cdk1 CDK1 P39951 rat APP 54226 P08592 App rat T743 448523 VEVDAAVtPEERHLS APP_amyloid X 3823; 6986 +Cdk1 CDK1 P39951 rat Caldesmon 25687 Q62736 Cald1 rat S497 448465 ksPDGNKsPAPkPSD Caldesmon X +Cdk1 CDK1 P39951 rat Src 396442 P00523 SRC chicken T46 455776 AAPDTHRtPsRSFGT X +Cdk1 CDK1 P39951 rat STMN2 84510 P21818 Stmn2 rat S73 450173 EAPRTLAsPKKkDLs Stathmin X +Cdk1 CDK1 P39951 rat Caldesmon 25687 Q62736 Cald1 rat S527 448466 QSVDKVTsPTKV___ X +Cdk1 CDK1 P39951 rat Src 396442 P00523 SRC chicken S72 450326 NTSDTVTsPQRAGAL X +Cdk1 CDK1 P39951 rat NMDAR2A 24409 Q00959 Grin2a rat S580 1871177709 VFVFEYFsPVGYNRN Lig_chan X X +Cdk1 CDK1 P39951 rat Caldesmon 25687 Q62736 Cald1 rat S249 450134 KQTENAFsPSRSGGR Caldesmon X +Cdk1 CDK1 P39951 rat BAD 64639 O35147 Bad rat S129 447861 EGMEEELsPFRGRsR Bcl-2_BAD X X +ABL1 Abl P00519 human YAP1 10413 P46937 YAP1 human Y407 473004 sGLsMsSySVPRtPD X X +ABL1 Abl P00519 human SOS1 20662 Q62245 Sos1 mouse Y1182 34550593 SKAYsPRysISDRTS X X +ABL1 Abl P00519 human DCBLD2 131566 Q96PD2 DCBLD2 human Y750 454600 PAPDELVyQVPQStQ X +ABL1 Abl P00519 human SMAD4 4089 Q13485 SMAD4 human Y301 1881244702 MPPHPGHyWPVHNEL X X +ABL1 Abl P00519 human DCBLD1 285761 Q8N8Z6 DCBLD1 human S657 25735581 GDyQRPHsAQPADRG X +ABL1 Abl P00519 human TBX21 30009 Q9UL17 TBX21 human Y305 20583305 QFIAVTAyQNAEITQ T-box X X +ABL1 Abl P00519 human Catalase 847 P04040 CAT human Y231 450444 NANGEAVyCkFHYkT Catalase X X +ABL1 Abl P00519 human smMLCK 4638 Q15746 MYLK human Y1449 4739881 EKEPEVDyRTVTINT X +ABL1 Abl P00519 human Abl 25 P00519 ABL1 human Y393 450298 RLMtGDtytAHAGAk PK_Tyr_Ser-Thr X X 2865 +ABL1 Abl P00519 human p73 7161 O15350 TP73 human Y99 448428 SVPTHSPyAQPSSTF X X 4665 +ABL1 Abl P00519 human DCBLD2 131566 Q96PD2 DCBLD2 human Y715 455062 PPPLVGtyNtLLsRt X +ABL1 Abl P00519 human ArgBP2 iso2 8470 O94875-2 SORBS2 human Y59 31834901 RPFSPSAySLPASLN X +ABL1 Abl P00519 human DCBLD2 131566 Q96PD2 DCBLD2 human Y565 458665 KKkTEGtyDLPyWDR X +ABL1 Abl P00519 human TOP1 21969 Q04750 Top1 mouse Y270 454026 AKMLDHEytTKEIFR Topoisom_I_N X +ABL1 Abl P00519 human CDC73 79577 Q6P1J9 CDC73 human Y315 15402684 KIDTMGTyHGMTLkS X +ABL1 Abl P00519 human Abi-1 11308 Q8CBW3 Abi1 mouse Y213 449523 PPTVPNDyMtsPARL X +ABL1 Abl P00519 human Catalase 12359 P24270 Cat mouse Y386 450445 yRARVANyQRDGPMC Catalase X +ABL1 Abl P00519 human DCBLD1 285761 Q8N8Z6 DCBLD1 human S695 1869653004 THPGTsDsysAPRDC X +ABL1 Abl P00519 human Met 4233 P08581 MET human Y1349 448472 stFIGEHyVHVNAty X 3133; 3121 +ABL1 Abl P00519 human HRas 3265 P01112 HRAS human Y137 41198101 AQDLARSyGIPYIEt Ras X +ABL1 Abl P00519 human Myc 4609 P01106 MYC human Y89 17553985 sGLCsPSyVAVtPFs Myc_N X +ABL1 Abl P00519 human BMPR1A 12166 P36895 Bmpr1a mouse Y458 25655002 EEyQLPyyNMVPSDP PK_Tyr_Ser-Thr X +ABL1 Abl P00519 human DAB1 13131 P97318 Dab1 mouse Y232 447961 SQKKEGVyDVPKSQP X 3325 +ABL1 Abl P00519 human MDM4 4194 O15151 MDM4 human Y55 6039501 TVKEVMHyLGQYIMV SWIB X +ABL1 Abl P00519 human BCAP 118788 Q6ZUJ8 PIK3AP1 human Y513 3971796 LGQEEDVyHTVDDDE X +ABL1 Abl P00519 human PDGFRB 5159 P09619 PDGFRB human Y970 4833940 GEGYKKKyQQVDEEF X +ABL1 Abl P00519 human Tip60 10524 Q92993 KAT5 human Y294 29431804 HPPGNEIyRkGTISF MOZ_SAS X X +ABL1 Abl P00519 human JAK2 16452 Q62120 Jak2 mouse Y1008 448408 LPQDKEyyKVKEPGE PK_Tyr_Ser-Thr X 3771; 3776; 8082; 66245; 32901 +ABL1 Abl P00519 human Myc 4609 P01106 MYC human Y47 27530806 CDEEENFyQQQQQSE Myc_N X +ABL1 Abl P00519 human CRK 1398 P46108 CRK human Y221 447951 GGPEPGPyAQPsVNt X X 3491 +ABL1 Abl P00519 human CASP9 842 P55211 CASP9 human Y153 455198 RGNADLAyILSMEPC X X +ABL1 Abl P00519 human PLSCR1 5359 O15162 PLSCR1 human Y69 2915403 PVPNQPVyNQPVyNQ X +ABL1 Abl P00519 human Rin1 225870 Q921Q7 Rin1 mouse Y35 450778 KPstDPLyDTPDTRG X +ABL1 Abl P00519 human ANXA1 301 P04083 ANXA1 human Y21 447974 IENEEQEyVQtVkss X +ABL1 Abl P00519 human P38A 26416 P47811 Mapk14 mouse Y323 455799 DEPVADPyDQSFESR X X +ABL1 Abl P00519 human PXN 5829 P49023 PXN human Y118 448604 VGEEEHVysFPNkQk Paxillin X 2541; 69363 +ABL1 Abl P00519 human SMAD4 4089 Q13485 SMAD4 human Y195 1881244700 NRASTETyStPALLA X X +ABL1 Abl P00519 human ROBO1 6091 Q9Y6N7 ROBO1 human Y1038 13249800 MLPESTVyGDVDLSN X +ABL1 Abl P00519 human YB-1 22608 P62960 Ybx1 mouse Y70 3797338 WFNVRNGyGFINRND CSD X X +ABL1 Abl P00519 human CRKL 1399 P46109 CRKL human Y207 447954 IPEPAHAyAQPQttt X X 3181; 34940; 94358 +ABL1 Abl P00519 human VAV1 7409 P15498 VAV1 human Y174 447866 EAEGDEIyEDLMRsE X +ABL1 Abl P00519 human p63 8626 Q9H3D4 TP63 human Y290 10359106 RQSVLVPyEPPQVGT P53 X +ABL1 Abl P00519 human PIK3R1 282307 P23727 PIK3R1 cow Y368 448134 STKMHGDyTLTLRKG SH2 X +ABL1 Abl P00519 human vinexin 282843 NP_001005762 Sorbs3 rat Y127 466573 QHPDPAWyQTWPGPG X X +ABL1 Abl P00519 human DCBLD2 131566 Q96PD2 DCBLD2 human T756 1869653001 VyQVPQStQEVsGAG X +ABL1 Abl P00519 human Rb 5925 P06400 RB1 human Y805 456752 rIPGGNIyIsPLksP Rb_C X X +ABL1 Abl P00519 human NOX5 79400 Q96PH1 NOX5 human Y476 1869973807 FHYRPGDyLyLNIPT FAD_binding_8 X +ABL1 Abl P00519 human FHL2 2274 Q14192 FHL2 human Y176 23106943 ITTGGVtyREQPWHK LIM X +ABL1 Abl P00519 human MDM2 4193 Q00987 MDM2 human Y394 455777 QsQESEDysQPSTSS X X +ABL1 Abl P00519 human ER-alpha 2099 P03372 ESR1 human Y219 12620700 sIQGHNDyMCPATNQ zf-C4 X X +ABL1 Abl P00519 human BMPR1A 12166 P36895 Bmpr1a mouse Y453 3712679 TGGIVEEyQLPyyNM PK_Tyr_Ser-Thr X +ABL1 Abl P00519 human RAPGEF1 2889 Q13905 RAPGEF1 human Y504 448393 APIPSVPyAPFAAIL X X +ABL1 Abl P00519 human PLK1 5347 P53350 PLK1 human Y445 54066601 DSTRLILyNDGDsLQ POLO_box X X +ABL1 Abl P00519 human CRK 1398 P46108 CRK human Y239 450357 NLQNGPIyARVIQKR SH3_2 X X +ABL1 Abl P00519 human ZAP70 7535 P43403 ZAP70 human Y319 447587 tsVyEsPysDPEELk X 2701; 2717; 14791; 73382; 82975; 31754 +ABL1 Abl P00519 human JunB 3726 P17275 JUNB human Y182 41655504 GPEPPPVyTNLSSyS Jun X +ABL1 Abl P00519 human EGFR 1956 P00533 EGFR human Y1092 448057 tFLPVPEyINQsVPk X 2236; 2234; 3777; 14565; 8543; 48576 +ABL1 Abl P00519 human DCBLD2 131566 Q96PD2 DCBLD2 human S600 4149428 tPVRysssEVNHLsP X +ABL1 Abl P00519 human Abi-1 10006 Q8IZP0 ABI1 human Y213 449523 PPtVPNDyMtsPARL X X +ABL1 Abl P00519 human MAVS 57506 Q7Z434 MAVS human Y30 63080401 DVVEILPyLPCLTAR CARD_2 X +ABL1 Abl P00519 human PHF5A 84844 Q7RTV0 PHF5A human Y36 463988 kCVICDSyVRPCTLV PHF5 X X +ABL1 Abl P00519 human p63 8626 Q9H3D4 TP63 human Y149 452168 SVTAPSPyAQPSSTF X 4665 +ABL1 Abl P00519 human Abl iso2 25 P00519-2 ABL1 human Y412 450298 RLMTGDtyTAHAGAK PK_Tyr_Ser-Thr X 2865 +ABL1 Abl P00519 human DCBLD1 285761 Q8N8Z6 DCBLD1 human S697 1869653010 PGTsDsysAPRDCLT X +ABL1 Abl P00519 human PXN 5829 P49023 PXN human Y31 448785 FLSEEtPysyPtGNH X +ABL1 Abl P00519 human WASF3 10810 Q9UPY6 WASF3 human Y151 486448 KKDGLKFyTDPSyFF X +ABL1 Abl P00519 human DCBLD1 285761 Q8N8Z6 DCBLD1 human Y665 38483937 AQPADRGyDRPKAVs X +ABL1 Abl P00519 human PDGFRB 5159 P09619 PDGFRB human Y686 7437801 IITEyCRyGDLVDyL PK_Tyr_Ser-Thr X +ABL1 Abl P00519 human DCBLD2 131566 Q96PD2 DCBLD2 human S598 4033223 EEtPVRysssEVNHL X +ABL1 Abl P00519 human CDC73 79577 Q6P1J9 CDC73 human Y293 20831311 IPAAyNRyDQERFkG CDC73_N X +ABL1 Abl P00519 human CASP9 842 P55211 CASP9 human Y397 286046008 AVSVkGIyKQMPGCF Peptidase_C14 X X +ABL1 Abl P00519 human PYCARD 29108 Q9ULZ3 PYCARD human Y146 465096 kVLTDEQyQAVRAEP CARD X +ABL1 Abl P00519 human CD19 930 P15391 CD19 human Y508 459617 EDMRGILyAAPQLRs X +ABL1 Abl P00519 human p27Kip1 1027 P46527 CDKN1B human Y88 456818 kGsLPEFyyRPPRPP X X +ABL1 Abl P00519 human CTNNB1 1499 P35222 CTNNB1 human Y86 447584 VADIDGQyAMTRAQR X X +ABL1 Abl P00519 human FOXA1 3169 P55317 FOXA1 human Y429 60189900 QALQYsPyGSTLPAS HNF_C X +ABL1 Abl P00519 human smMLCK 4638 Q15746 MYLK human Y792 15712003 QPWHAGQyEILLKNR I-set X +ABL1 Abl P00519 human smMLCK 4638 Q15746 MYLK human Y464 451414 QEGsIEVyEDAGsHy I-set X X +ABL1 Abl P00519 human DCBLD2 131566 Q96PD2 DCBLD2 human Y655 478857 GyADLDPyNsPGQEV X +ABL1 Abl P00519 human JunB 3726 P17275 JUNB human Y173 41655503 PAGPGGVyAGPEPPP Jun X +ABL1 Abl P00519 human SNCA 6622 P37840 SNCA human Y125 448279 VDPDNEAyEMPsEEG Synuclein X +ABL1 Abl P00519 human NOX5 79400 Q96PH1 NOX5 human Y478 1869973808 YRPGDyLyLNIPTIA FAD_binding_8 X +ABL1 Abl P00519 human smMLCK 4638 Q15746 MYLK human Y231 15712000 NQDDVGVyTCLVVNG I-set X +ABL1 Abl P00519 human smMLCK 4638 Q15746 MYLK human Y846 15712001 DGGGSDRyGsLRPGW X +ABL1 Abl P00519 human BCAP 118788 Q6ZUJ8 PIK3AP1 human Y594 459548 DRPQssIyDPFAGMk X +ABL1 Abl P00519 human GPX1 2876 P07203 GPX1 human Y98 455673 EILNSLkyVRPGGGF GSHPx X X +ABL1 Abl P00519 human SNIP 80725 Q9C0H9 SRCIN1 human Y396 456704 LVKGEGLyADPyGLL X X +ABL1 Abl P00519 human eNOS 4846 P29474 NOS3 human Y81 456466 WEVGSITyDTLSAQA X +ABL1 Abl P00519 human DCBLD2 131566 Q96PD2 DCBLD2 human S760 51390534 PQStQEVsGAGRDGE X +ABL1 Abl P00519 human MDM4 4194 O15151 MDM4 human Y99 6039500 VkDPsPLyDMLRKNL X +ABL1 Abl P00519 human HIPK2 28996 Q9H2X6 HIPK2 human Y367 1033356 tyLQsRYyRAPEIIL Pkinase X +ABL1 Abl P00519 human TIF1G 51592 Q9UPN9 TRIM33 human Y1048 15406627 MMKVVQVyADtQEIN Bromodomain X +ABL1 Abl P00519 human TBX21 30009 Q9UL17 TBX21 human Y220 20583307 SMPGNRLyVHPDSPN T-box X X +ABL1 Abl P00519 human PSMA7 5688 O14818 PSMA7 human Y106 15570108 EDPVTVEyItRyIAS Proteasome X +ABL1 Abl P00519 human PPAR-gamma 5468 P37231 PPARG human Y78 36692605 SSISTPHyEDIPFTR PPARgamma_N X +ABL1 Abl P00519 human ATR 545 Q13535 ATR human Y291 15434301 DTDQLKLyEEPLSkL X X +ABL1 Abl P00519 human SHP-2 19247 P35235 Ptpn11 mouse Y542 448492 sKRKGHEytNIKYSL X 3751; 94740; 15543; 64117 +ABL1 Abl P00519 human DCBLD2 131566 Q96PD2 DCBLD2 human Y649 473121 EEGKEAGyADLDPyN X +ABL1 Abl P00519 human AHSA1 10598 O95433 AHSA1 human Y223 3914778 LtsPEELyRVFTTQE AHSA1 X X +ABL1 Abl P00519 human DCBLD1 285761 Q8N8Z6 DCBLD1 human Y589 3782797 QRAGRHEyALPLAPP X +ABL1 Abl P00519 human PKCD 170538 P09215 Prkcd rat Y155 447575 IKQAKIHyIKNHEFI X +ABL1 Abl P00519 human DRP1 10059 O00429 DNM1L human Y266 297110000 TDSIRDEyAFLQkkY Dynamin_M X X +ABL1 Abl P00519 human SORBS1 iso5 20411 Q62417-5 Sorbs1 mouse Y632 11498500 LCSYQALySYVPQND SH3_9 X +ABL1 Abl P00519 human galectin-3 3958 P17931 LGALS3 human Y107 14823408 AYPATGPyGAPAGPL X X +ABL1 Abl P00519 human galectin-3 3958 P17931 LGALS3 human Y79 13213701 GAPAPGVyPGPPSGP X X +ABL1 Abl P00519 human BMPR1A 12166 P36895 Bmpr1a mouse Y457 25655000 VEEyQLPyyNMVPSD PK_Tyr_Ser-Thr X +ABL1 Abl P00519 human DCBLD1 285761 Q8N8Z6 DCBLD1 human Y600 3479143 LAPPEPEyAtPIVER X +ABL1 Abl P00519 human WASF3 10810 Q9UPY6 WASF3 human Y486 486451 SRRIAVEySDSDDDS X +ABL1 Abl P00519 human DCBLD1 285761 Q8N8Z6 DCBLD1 human S556 11098235 GTVTRKGsTFRPMDT X +ABL1 Abl P00519 human ER-beta 2100 Q92731 ESR2 human Y36 34425602 SIYIPSSyVDSHHEY ERbeta_N X +ABL1 Abl P00519 human RAD51 5888 Q06609 RAD51 human Y54 449958 HTVEAVAyAPkkELI HHH_5 X X +ABL1 Abl P00519 human EGFR 1956 P00533 EGFR human Y1197 448060 stAENAEyLRVAPQS X 2244; 4407; 47737 +ABL1 Abl P00519 human GLO1 2739 Q04760 GLO1 human Y136 463450 GIAVPDVysACkRFE Glyoxalase X +ABL1 Abl P00519 human STX17 55014 P56962 STX17 human Y157 479165 SQSLTQIyALPEIPQ X +ABL1 Abl P00519 human PPAR-gamma 5468 P37231 PPARG human Y102 9256871 yDLKLQEyQSAIkVE PPARgamma_N X +ABL1 Abl P00519 human Geminin 51053 O75496 GMNN human Y150 33402208 EVAEHVQyMAELIER Geminin X X +ABL1 Abl P00519 human SNCA 6622 P37840 SNCA human Y39 3546424 kTkEGVLyVGsKTkE Synuclein X X +ABL1 Abl P00519 human N-WASP Q95107 WASL cow Y256 450253 RETSKVIyDFIEKTG PBD X X +ABL1 Abl P00519 human IkB-alpha 4792 P25963 NFKBIA human Y305 448799 FtEDELPyDDCVFGG X +ABL1 Abl P00519 human MUC1 4582 P15941 MUC1 human Y1243 454879 NGGSsLsytNPAVAA X +ABL1 Abl P00519 human DCBLD1 285761 Q8N8Z6 DCBLD1 human S693 1869653005 PPTHPGTsDsysAPR X +ABL1 Abl P00519 human ArgBP2 iso2 8470 O94875-2 SORBS2 human Y573 11057708 NTKGAEDyPDPPIPH X +ABL1 Abl P00519 human NET1 56349 Q9Z206 Net1 mouse Y424 1881982102 TRNERHLyQVyRQPI X +ABL1 Abl P00519 human MIG-6 54206 Q9UJM3 ERRFI1 human Y394 451607 KKVsstHyyLLPERP X +ABL1 Abl P00519 human caveolin-1 857 Q03135 CAV1 human Y14 448422 VDsEGHLytVPIREQ X 3251 +ABL1 Abl P00519 human RAD51 5888 Q06609 RAD51 human Y315 448324 EtRICKIyDSPCLPE Rad51 X +ABL1 Abl P00519 human FOXA1 3169 P55317 FOXA1 human Y464 60189901 PAYYQGVySRPVLNT X +ABL1 Abl P00519 human RTCB 51493 Q9Y3I0 RTCB human Y316 1876333508 GMAAAGNyAWVNRSS RtcB X X +ABL1 Abl P00519 human ER-alpha 2099 P03372 ESR1 human Y52 12620701 DssKPAVyNYPEGAA Oest_recep X X +ABL1 Abl P00519 human ATR 545 Q13535 ATR human Y310 15434300 FPFEAEAyRNIEPVY X X +ABL1 Abl P00519 human DAB1 13131 P97318 Dab1 mouse Y220 447630 PETEENIyQVPTSQK X 3327 +ABL1 Abl P00519 human Bcr 613 P11274 BCR human Y177 447792 ADAEKPFyVNVEFHH X X 3901 +ABL1 Abl P00519 human PLCG1 5335 P19174 PLCG1 human Y1003 3954534 KGKKFLQyNRLQLSR PI-PLC-Y X +ABL1 Abl P00519 human Met 4233 P08581 MET human Y1356 448473 yVHVNAtyVNVKCVA X +ABL1 Abl P00519 human BMPR1A 12166 P36895 Bmpr1a mouse Y467 25655001 MVPSDPSyEDMREVV PK_Tyr_Ser-Thr X +ABL1 Abl P00519 human Btk 695 Q06187 BTK human Y223 447485 LKKVVALyDyMPMNA SH3_1 X 5082; 87141; 87457 +ABL1 Abl P00519 human Catalase 12359 P24270 Cat mouse Y231 450444 NADGEAVyCkFHYkT Catalase X +ABL1 Abl P00519 human EGFR 1956 P00533 EGFR human Y1016 448055 DVVDADEyLIPQQGF X 2235 +ABL1 Abl P00519 human RACK1 10399 P63244 RACK1 human Y52 464119 LtrDEtNyGIPQRAL X X +ABL1 Abl P00519 human ArgBP2 iso2 8470 O94875-2 SORBS2 human Y175 7783536 YTYNAGLyNPPYSAQ X +ABL1 Abl P00519 human Arg 27 P42684 ABL2 human Y261 455657 GLVTTLHyPAPKCNK X X +ABL1 Abl P00519 human MST2 6788 Q13188 STK3 human Y81 25528501 MQQCDSPyVVKYYGS Pkinase X X +ABL1 Abl P00519 human PLCG1 5335 P19174 PLCG1 human Y771 448575 IGtAEPdyGALyEGR X X +ABL1 Abl P00519 human PLK1 5347 P53350 PLK1 human Y217 464048 tLCGtPNyIAPEVLs Pkinase X X +ABL1 Abl P00519 human Skip 22938 Q13573 SNW1 human Y292 464278 AKLAEALyIADRKAR SKIP_SNW X +ABL1 Abl P00519 human BCAP 118788 Q6ZUJ8 PIK3AP1 human Y570 450912 QERPGNFyVSSEsIR X +ABL1 Abl P00519 human C/EBP-beta 1051 P17676 CEBPB human Y78 9397201 RAIDFsPyLEPLGAP X +ABL1 Abl P00519 human DCBLD1 285761 Q8N8Z6 DCBLD1 human Y540 1869653009 ITsDMADyQQPLMIG X +ABL1 Abl P00519 human FAM105B 90268 Q96BN8 OTULIN human Y56 3560103 AEHEEDMyRAADEIE X X +ABL1 Abl P00519 human Jun 3725 P05412 JUN human Y170 447687 LHSEPPVyANLSNFN Jun X +ABL1 Abl P00519 human IRF3 3661 Q14653 IRF3 human Y292 1867930600 rLGHCHTyWAVSEEL IRF-3 X +ABL1 Abl P00519 human DCBLD2 131566 Q96PD2 DCBLD2 human Y597 4033219 HEEtPVRysssEVNH X +ABL1 Abl P00519 human CRK 417553 Q04929 CRK chicken Y222 447951 GGPEPGPyAQPSINT X X +ABL1 Abl P00519 human DCBLD2 131566 Q96PD2 DCBLD2 human Y621 454599 LQADsAEyAQPLVGG X +ABL1 Abl P00519 human Cortactin 2017 Q14247 CTTN human Y486 447704 yPAEDStyDEYENDL X +ABL1 Abl P00519 human p63 8626 Q9H3D4 TP63 human Y171 10359107 AIPSNTDyPGPHSFD P53 X +ABL1 Abl P00519 human SRC-3 8202 Q9Y6Q9 NCOA3 human Y1357 4668109 HPQAASIyQSSEMKG X X +ABL1 Abl P00519 human RNPC2 9584 Q14498 RBM39 human Y95 3196190 DRRFRGRyrsPysGP X +ABL1 Abl P00519 human Skip 22938 Q13573 SNW1 human Y433 459533 EDEIyNVyDQAWrGG X +ABL1 Abl P00519 human emerin 2010 P50402 EMD human Y167 449653 AyQsItHyRPVsAsR X +ABL1 Abl P00519 human DCBLD2 131566 Q96PD2 DCBLD2 human T679 1869653002 ITGPEyAtPIIMDMS X +ABL1 Abl P00519 human NCK1 4690 P16333 NCK1 human Y105 448953 VDPGERLyDLNMPAy X X +ABL1 Abl P00519 human BCAP 118788 Q6ZUJ8 PIK3AP1 human Y694 450993 AKVEFGVyEsGPRKs X +ABL1 Abl P00519 human CRK 12928 Q64010 Crk mouse Y221 447951 GGPEPGPyAQPsVNt X 3491 +ABL1 Abl P00519 human PSD-95 29495 P31016 Dlg4 rat Y533 473111 VTQMEVHyARPIIIL Guanylate_kin X +ABL1 Abl P00519 human DCBLD2 131566 Q96PD2 DCBLD2 human Y677 475112 LPITGPEyAtPIIMD X +ABL1 Abl P00519 human Catalase 847 P04040 CAT human Y386 450445 yRARVANyQRDGPMC Catalase X X +ABL1 Abl P00519 human p21Cip1 12575 P39689 Cdkn1a mouse Y76 26400605 SLGLPKVyLsPGSRS X +ABL1 Abl P00519 human RAD52 5893 P43351 RAD52 human Y104 449061 DLNNGKFyVGVCAFV Rad52_Rad22 X +ABL1 Abl P00519 human ROBO1 6091 Q9Y6N7 ROBO1 human Y1114 465166 QEVAPVQyNIVEQNk X +ABL1 Abl P00519 human YAP1 iso3 10413 P46937-3 YAP1 human Y357 473004 SGLSMSSySVPRtPD X +ABL1 Abl P00519 human WASF3 10810 Q9UPY6 WASF3 human Y337 486450 LPAQIIEyYNPSGPP X +ABL1 Abl P00519 human SORBS1 iso5 20411 Q62417-5 Sorbs1 mouse Y326 460519 RAEPKSIyEYQPGKS X +ABL1 Abl P00519 human DDX5 1655 P17844 DDX5 human Y593 470084 NGMNQQAyAyPATAA X X +ABL1 Abl P00519 human DCBLD1 285761 Q8N8Z6 DCBLD1 human S513 4775486 yPFARHQsAEFtISY X +ABL1 Abl P00519 human PLK1 5347 P53350 PLK1 human Y425 62370600 SDkYGLGyQLCDNSV POLO_box X X +ABL1 Abl P00519 human DCBLD2 131566 Q96PD2 DCBLD2 human S618 23097815 TTVLQADsAEyAQPL X +ABL1 Abl P00519 human CDC73 79577 Q6P1J9 CDC73 human Y290 3449102 kQPIPAAyNRyDQER CDC73_N X +ABL1 Abl P00519 human RhoGDI beta 397 P52566 ARHGDIB human Y24 448978 ELdskLNykPPPQks Rho_GDI X X +ABL1 Abl P00519 human TBX21 30009 Q9UL17 TBX21 human Y266 20583306 VLQsLHKyQPRLHIV T-box X X +ABL1 Abl P00519 human smMLCK 4638 Q15746 MYLK human Y1635 15712005 VAPEVINyEPIGYAT Pkinase X +ABL1 Abl P00519 human JunB 3726 P17275 JUNB human Y188 41655505 VyTNLSSySPASASS Jun X +ABL1 Abl P00519 human DCBLD2 131566 Q96PD2 DCBLD2 human Y666 478858 GQEVyHAyAEPLPIT X +ABL1 Abl P00519 human Abi-1 11308 Q8CBW3 Abi1 mouse Y428 3589548 IEKVVAIyDYTKDKD SH3_1 X +ABL1 Abl P00519 human BCAP 118788 Q6ZUJ8 PIK3AP1 human Y553 13203803 QLPDNEPyIFKVFAE X +ABL1 Abl P00519 human GMF-gamma 9535 O60234 GMFG human Y104 33670301 kPEQQMMyAGSkNRL Cofilin_ADF X X +ABL1 Abl P00519 human SNIP 80725 Q9C0H9 SRCIN1 human Y264 456703 IYRKEPLyAAFPGSH AIP3 X X +ABL1 Abl P00519 human PSMA7 5688 O14818 PSMA7 human Y153 456317 QTDPsGtyHAWkANA Proteasome X X +ABL1 Abl P00519 human TIF1G 51592 Q9UPN9 TRIM33 human Y524 15416086 QHMQQQVyAQKHQQL X +ABL1 Abl P00519 human p27Kip1 1027 P46527 CDKN1B human Y89 456819 GsLPEFyyRPPRPPK X +ABL1 Abl P00519 human NuMA-1 4926 Q14980 NUMA1 human Y1774 449717 VEsLEsLyFtPIPAR X X +ABL1 Abl P00519 human P38A 26416 P47811 Mapk14 mouse Y182 447971 tDDEMtGyVAtRWYR Pkinase X X 9211; 9215; 4551; 9216; 4552; 4631; 4511; 4092; 9219; 24678; 8632; 6908; 41768; 51255; 14594; 14598; 62979 +ABL1 Abl P00519 human DCBLD1 285761 Q8N8Z6 DCBLD1 human Y578 3470366 STDAGGHyDCPQRAG X +ABL1 Abl P00519 human CRK 1398 P46108 CRK human Y251 456549 QKRVPNAyDktALAL SH3_2 X X +ABL1 Abl P00519 human DRP1 10059 O00429 DNM1L human Y368 15569023 CGGARICyIFHETFG Dynamin_M X X +ABL1 Abl P00519 human PARIS 155061 Q6NUN9 ZNF746 human Y137 13831906 ETLVSLDyAISKPEV X X +ABL1 Abl P00519 human DCBLD2 131566 Q96PD2 DCBLD2 human T593 27447065 kAVDHEEtPVRysss X +ABL1 Abl P00519 human TUBG1 7283 P23258 TUBG1 human Y443 1876567500 HAATRPDyISWGTQE X +ABL1 Abl P00519 human PLEKHG2 64857 Q9H7P9 PLEKHG2 human Y489 23133014 sEPVKDPyVMFPQNA X +ABL1 Abl P00519 human DDB1 1642 Q16531 DDB1 human Y182 62873405 APTICFVyQDPQGRH MMS1_N X +ABL1 Abl P00519 human ArgBP2 iso2 8470 O94875-2 SORBS2 human Y50 31834902 AVSPMSYyQRPFSPS X +ABL1 Abl P00519 human galectin-3 3958 P17931 LGALS3 human Y118 13213700 AGPLIVPyNLPLPGG Gal-bind_lectin X X +ABL1 Abl P00519 human N-WASP Q95107 WASL cow Y175 458041 EITTNRFyGPQINNI X X +ABL1 Abl P00519 human SGK223 157285 Q86YV5 PRAG1 human Y413 449701 ATQPEPIyAEsTKRK X +ABL1 Abl P00519 human smMLCK 4638 Q15746 MYLK human Y611 462699 KSSRkSEyLLPVAPS X +ABL1 Abl P00519 human CTNNB1 1499 P35222 CTNNB1 human Y489 462002 QNAVRLHyGLPVVVk X +ABL1 Abl P00519 human CTNNB1 1499 P35222 CTNNB1 human Y654 447585 RNEGVAtyAAAVLFR X X +ABL1 Abl P00519 human ArgBP2 iso2 8470 O94875-2 SORBS2 human Y164 23083166 PDDDTDMyNTPYTYN X +ABL1 Abl P00519 human DRP1 10059 O00429 DNM1L human Y449 297110001 IIQHCSNySTQELLR Dynamin_M X X +ABL1 Abl P00519 human SHP-2 19247 P35235 Ptpn11 mouse Y63 455054 IQNTGDyyDLyGGEK SH2 X +ABL1 Abl P00519 human PLSCR1 5359 O15162 PLSCR1 human Y74 464050 PVyNQPVyNQPVGAA X +ABL1 Abl P00519 human ERCC6 2074 Q03468 ERCC6 human Y932 486324 GANRVVIyDPDWNPS Helicase_C X +ABL1 Abl P00519 human JAK2 16452 Q62120 Jak2 mouse Y1007 448407 VLPQDKEyyKVKEPG PK_Tyr_Ser-Thr X 3771; 3776; 4406; 66245; 32901 +ABL1 Abl P00519 human DCBLD2 131566 Q96PD2 DCBLD2 human T714 15409263 QPPPLVGtyNtLLsR X +ABL1 Abl P00519 human PARK2 5071 O60260 PRKN human Y143 15624700 sPAGRSIyNSFYVYC X X +ABL1 Abl P00519 human TAZ 97064 Q9EPK5 Wwtr1 mouse Y316 27138200 sGLGLGCySVPTTPE X X +ABL1 Abl P00519 human smMLCK 4638 Q15746 MYLK human Y556 15712002 LNGQPIQyARSTCEA I-set X +ABL1 Abl P00519 human Skip 22938 Q13573 SNW1 human Y430 459532 AGGEDEIyNVyDQAW X +ABL1 Abl P00519 human FHL2 2274 Q14192 FHL2 human Y97 473390 TDCySNEySSkCQEC LIM X +ABL1 Abl P00519 human RAD9A 5883 Q99638 RAD9A human Y28 447825 SRIGDELyLEPLEDG Rad9 X X +ABL1 Abl P00519 human SPTLC1 10558 O15269 SPTLC1 human Y164 27930808 KTEEAIIySYGFATI Aminotran_1_2 X X +ABL1 Abl P00519 human MAVS 57506 Q7Z434 MAVS human Y71 63080400 RRPGWVEyFIAALRG CARD_2 X +ABL1 Abl P00519 human CHCHD2 51142 Q9Y6H1 CHCHD2 human Y99 62463400 PARPDITyQEPQGTQ X +ABL1 Abl P00519 human MST1 6789 Q13043 STK4 human Y433 463558 kIPQDGDyEFLksWt Mst1_SARAH X X +ABL1 Abl P00519 human PDGFRB 5159 P09619 PDGFRB human Y934 447518 AHAsDEIyEIMQKCW PK_Tyr_Ser-Thr X +ABL1 Abl P00519 human RNPC2 9584 Q14498 RBM39 human Y99 12244420 RGRyrsPysGPkFNs X +ABL1 Abl P00519 human NFAT5 10725 O94916 NFAT5 human Y143 12127405 PkRHtVLyIsPPPED X +ABL1 Abl P00519 human DCBLD2 131566 Q96PD2 DCBLD2 human Y663 3974132 NsPGQEVyHAyAEPL X +ABL1 Abl P00519 human MIG-6 54206 Q9UJM3 ERRFI1 human Y395 454989 KVsstHyyLLPERPP X +ABL1 Abl P00519 human TIF1G 51592 Q9UPN9 TRIM33 human Y610 25756330 PrHSGPQySMMQPHL X +ABL1 Abl P00519 human WASF3 10810 Q9UPY6 WASF3 human Y248 486449 HASDVtDySYPATPN X +ABL1 Abl P00519 human HDAC2 3066 Q92769 HDAC2 human Y222 464957 IGAGkGkyYAVNFPM Hist_deacetyl X +ABL1 Abl P00519 human FHL2 2274 Q14192 FHL2 human Y236 25292373 SGLGGTkyIsFEERQ LIM X +ABL1 Abl P00519 human SORBS1 iso5 20411 Q62417-5 Sorbs1 mouse Y360 3782802 SEPPGYIySSNFHAV X +ABL1 Abl P00519 human YB-1 22608 P62960 Ybx1 mouse Y97 15416754 kkNNPRKyLRsVGDG CSD X X +ABL1 Abl P00519 human ROBO1 6091 Q9Y6N7 ROBO1 human Y1073 465118 PSGQPTPyAtTQLIQ X X +ABL1 Abl P00519 human smMLCK 4638 Q15746 MYLK human Y1575 15712004 QISEGVEyIHKQGIV Pkinase X +ABL1 Abl P00519 human PDHA1 5160 P08559 PDHA1 human Y301 454753 MsDPGVsyRtREEIQ E1_dh X +ABL1 Abl P00519 human MyoD 17927 P10085 Myod1 mouse Y30 449872 FETADDFyDDPCFDs Basic X X +ABL1 Abl P00519 human MyoD 17927 P10085 Myod1 mouse Y212 449871 CSDGMMDySGPPSGP Myf5 X X +ABL1 Abl P00519 human MDM2 4193 Q00987 MDM2 human Y276 465467 sDEDDEVyQVtVyQA X X +ABL1 Abl P00519 human RTCB 51493 Q9Y3I0 RTCB human Y306 55380503 AsPEGQDyLkGMAAA RtcB X X +ABL1 Abl P00519 human PDHK1 5163 Q15118 PDK1 human Y243 462384 ARRLCDLyyINSPEL X +ABL1 Abl P00519 human hnRNP P2 2521 P35637 FUS human Y526 50318713 QDrrErPy_______ X +ABL1 Abl P00519 human FHL2 2274 Q14192 FHL2 human Y217 1873117006 LNCFCDLyAKkCAGC LIM X +ABL1 Abl P00519 human DCBLD2 131566 Q96PD2 DCBLD2 human S599 477979 EtPVRysssEVNHLs X +ABL1 Abl P00519 human NET1 56349 Q9Z206 Net1 mouse Y427 1881982104 ERHLyQVyRQPIPVQ X +ABL1 Abl P00519 human MDM2 4193 Q00987 MDM2 human Y405 465468 STSSSIIyssQEDVK X +ABL1 Abl P00519 human DCBLD1 285761 Q8N8Z6 DCBLD1 human Y621 3476708 tFsAQsGyRVPGPQP X +ABL1 Abl P00519 human DCBLD1 285761 Q8N8Z6 DCBLD1 human Y696 482942 HPGTsDsysAPRDCL X +ABL1 Abl P00519 human Lasp-1 3927 Q14847 LASP1 human Y171 451675 IPtsAPVyQQPQQQP X X +ABL1 Abl P00519 human PRKD1 5587 Q15139 PRKD1 human Y463 448648 NDTGsRYyKEIPLSE PH X X +ABL1 Abl P00519 human YY1 7528 P25490 YY1 human Y254 464367 sPPDySEyMTGkKLP X X +ABL1 Abl P00519 human RhoGDI beta 397 P52566 ARHGDIB human Y130 4113623 LkYVQHtyRTGVkVD Rho_GDI X X +ABL1 Abl P00519 human DDB1 1642 Q16531 DDB1 human Y718 1243008 HIRtVPLyEsPRkIC X +ABL1 Abl P00519 human WASP 7454 P42768 WAS human Y291 447985 AEtsKLIyDFIEDQG PBD X +ABL1 Abl P00519 human CKMT1A 548596 P12532 CKMT1B human Y153 475235 AsKIRsGyFDErYVL X X +ABL1 Abl P00519 human DCBLD1 285761 Q8N8Z6 DCBLD1 human S535 1869653012 QkLDLITsDMADyQQ X +ABL1 Abl P00519 human Tip60 10524 Q92993 KAT5 human Y44 28132103 ISGRKLFyVHYIDFN Tudor-knot X +ABL1 Abl P00519 human WAVE2 242687 Q8BH43 Wasf2 mouse Y150 455197 GKEALKFyTNPSyFF X +ABL1 Abl P00519 human MAVS 57506 Q7Z434 MAVS human Y9 25687502 PFAEDkTykyICRNF CARD_2 X +ABL1 Abl P00519 human SHP-2 19247 P35235 Ptpn11 mouse Y580 448493 REDsARVyENVGLMQ X X 3703; 5431; 13328 +ABL1 Abl P00519 human RTCB 51493 Q9Y3I0 RTCB human Y475 1876333510 MEEAPESykNVTDVV RtcB X X +ABL1 Abl P00519 human DCBLD1 285761 Q8N8Z6 DCBLD1 human Y652 2424923 VGAQDGDyQRPHsAQ X +ABL1 Abl P00519 human TOP1 7150 P11387 TOP1 human Y268 454026 AkMLDHEyTTkEIFR Topoisom_I_N X +ABL1 Abl P00519 human NFAT5 D3ZGB1 Nfat5 rat Y160 12127405 PKRHTVLyISPPPED X X +ABL1 Abl P00519 human SMAD4 4089 Q13485 SMAD4 human Y322 1881244704 SNHPAPEyWCSIAYF X +ABL1 Abl P00519 human VAV1 7409 P15498 VAV1 human Y267 460537 TPGAANLyQVFIKYK RhoGEF X +Mtor mTOR P42346 rat IRS1 25467 P35570 Irs1 rat S423 17550915 sDGGFIssDEYGSSP X X +Mtor mTOR P42346 rat 4E-BP1 13685 Q60876 Eif4ebp1 mouse T45 447496 GGtLFsttPGGtRII eIF_4EBP X 2855; 9459; 2846; 4923; 5123; 3929; 7547; 45613; 39788 +Mtor mTOR P42346 rat 4E-BP1 116636 Q62622 Eif4ebp1 rat S64 447527 FLMECRNsPVAKtPP eIF_4EBP X 9451; 9456 +Mtor mTOR P42346 rat IRS1 25467 P35570 Irs1 rat S422 40511593 PsDGGFIssDEYGSS X X +Mtor mTOR P42346 rat 4E-BP1 13685 Q60876 Eif4ebp1 mouse T36 447497 PPGDysttPGGtLFs eIF_4EBP X 2855; 9459; 2846; 4923; 5123; 3929; 7547; 45613; 39788 +Mtor mTOR P42346 rat 4E-BP1 116636 Q62622 Eif4ebp1 rat T45 447496 GGtLFSttPGGtRII eIF_4EBP X 2855; 9459; 2846; 5123; 3929; 7547; 45613; 39788 +Mtor mTOR P42346 rat 4E-BP1 116636 Q62622 Eif4ebp1 rat T36 447497 PPGDYsttPGGtLFS eIF_4EBP X 2855; 9459; 2846; 5123; 3929; 7547; 45613; 39788 +Mtor mTOR P42346 rat 4E-BP1 1978 Q13541 EIF4EBP1 human T37 447497 PPGDysttPGGtLFs eIF_4EBP X 2855; 9459; 2846; 5123; 3929; 7547; 45613; 39788 +Mtor mTOR P42346 rat 4E-BP1 1978 Q13541 EIF4EBP1 human T46 447496 GGtLFsttPGGtRII eIF_4EBP X 2855; 9459; 2846; 4923; 5123; 3929; 7547; 45613; 39788 +Mtor mTOR P42346 rat 4E-BP1 116636 Q62622 Eif4ebp1 rat S82 447525 PTIPGVTsPTSDEPP eIF_4EBP X +Mtor mTOR P42346 rat 4E-BP1 116636 Q62622 Eif4ebp1 rat T69 447528 RNsPVAKtPPKDLPT eIF_4EBP X 9455 +CDC7 CDC7 O00311 human NCL 4691 P19338 NCL human T121 470366 PGkALVAtPGkkGAA X +CDC7 CDC7 O00311 human claspin 63967 Q9HAW4 CLSPN human S1129 36898303 LADGDLHsDGPGRMR X +CDC7 CDC7 O00311 human DTD1 92675 Q8TEA8 DTD1 human S194 3072143 tPRKEDRsAssGAEG X +CDC7 CDC7 O00311 human TOP2A 7153 P11388 TOP2A human S1525 448764 PIKyLEEsDEDDLF_ X X +CDC7 CDC7 O00311 human DBF4 10926 Q9UBU7 DBF4 human S312 30988261 DLETHLLsEQHRNFA zf-DBF X +CDC7 CDC7 O00311 human CDC7 8317 O00311 CDC7 human S216 56757904 ELLkFVQsEAQQERC Pkinase X +CDC7 CDC7 O00311 human MCM2 4171 P49736 MCM2 human S41 452312 RtDALtssPGRDLPP X +CDC7 CDC7 O00311 human claspin 63967 Q9HAW4 CLSPN human S260 31088186 SLESGVHsFEEGsEL X +CDC7 CDC7 O00311 human DBF4 10926 Q9UBU7 DBF4 human T281 18909809 DGDKyGGtsIQLQLK X +CDC7 CDC7 O00311 human claspin 63967 Q9HAW4 CLSPN human S110 4748776 IYkTVADsDESYMEK X +CDC7 CDC7 O00311 human DTD1 92675 Q8TEA8 DTD1 human S196 476434 RKEDRsAssGAEGDV X +CDC7 CDC7 O00311 human claspin 63967 Q9HAW4 CLSPN human S1147 3685672 WKNIDDAsQMDLFHR X +CDC7 CDC7 O00311 human DTD1 92675 Q8TEA8 DTD1 human T187 36396302 EssKERNtPRKEDRs X +CDC7 CDC7 O00311 human CDC7 8317 O00311 CDC7 human S277 36123859 GKDGkEGsVGLSVQR X +CDC7 CDC7 O00311 human CDC7 8317 O00311 CDC7 human S296 31859383 ERNFNIHssISHEsP X +CDC7 CDC7 O00311 human MCM2 4171 P49736 MCM2 human S40 452311 RRtDALtssPGRDLP X X +CDC7 CDC7 O00311 human DTD1 92675 Q8TEA8 DTD1 human S181 36396300 RAKGPsEssKERNtP X +CDC7 CDC7 O00311 human DTD1 92675 Q8TEA8 DTD1 human S197 1983955 KEDRsAssGAEGDVs X +CDC7 CDC7 O00311 human NPM1 4869 P06748 NPM1 human T199 448515 VkKsIrDtPAkNAQK X 3541; 75984 +CDC7 CDC7 O00311 human MCM2 4171 P49736 MCM2 human S220 2201403 NVFkERIsDMCkENR MCM_N X +CDC7 CDC7 O00311 human claspin 63967 Q9HAW4 CLSPN human S721 4748805 sVPKsLssDstLLLF X +CDC7 CDC7 O00311 human DTD1 92675 Q8TEA8 DTD1 human S179 23112003 KTRAKGPsEssKERN X +CDC7 CDC7 O00311 human MCM2 4171 P49736 MCM2 human S31 2201404 LtssPGRssRRtDAL X +CDC7 CDC7 O00311 human MCM2 4171 P49736 MCM2 human S7 2201406 _MAEssEsFtMAssP X +CDC7 CDC7 O00311 human MFAP1 4236 P55081 MFAP1 human S116 452340 EPEVVGEsDsEVEGD X +CDC7 CDC7 O00311 human MCM2 4171 P49736 MCM2 human S5 2201405 ___MAEssEsFtMAs X X +CDC7 CDC7 O00311 human CDC7 8317 O00311 CDC7 human S318 56757903 SkTVDVLsRKLATKK X +CDC7 CDC7 O00311 human claspin 63967 Q9HAW4 CLSPN human S67 3212958 kVLQDsDsETEDTNA X +CDC7 CDC7 O00311 human DTD1 92675 Q8TEA8 DTD1 human S204 476435 sGAEGDVssErEP__ X +CDC7 CDC7 O00311 human AurB 9212 Q96GD4 AURKB human T236 4164705 RRktMCGtLDyLPPE Pkinase X +CDC7 CDC7 O00311 human CDC7 8317 O00311 CDC7 human S239 27445979 TGNkIPLsGPVPkEL X +CDC7 CDC7 O00311 human NCL 4691 P19338 NCL human T76 483581 tkkVAVAtPAkkAAV X +CDC7 CDC7 O00311 human CDC7 8317 O00311 CDC7 human S285 56757902 VGLSVQRsVFGERNF X +CDC7 CDC7 O00311 human CDC7 8317 O00311 CDC7 human S297 31859386 RNFNIHssISHEsPA X +CDC7 CDC7 O00311 human MCM2 4171 P49736 MCM2 human S4 2201407 ____MAEssEsFtMA X +CDC7 CDC7 O00311 human claspin 63967 Q9HAW4 CLSPN human S704 12200600 KENNDGssEIGkAVG X +CDC7 CDC7 O00311 human MCM2 4171 P49736 MCM2 human S108 456310 DVEELtAsQREAAER MCM2_N X X +CDC7 CDC7 O00311 human NPM1 4869 P06748 NPM1 human S137 476036 EEDVkLLsIsGkRsA X +CDC7 CDC7 O00311 human DTD1 92675 Q8TEA8 DTD1 human S205 485755 GAEGDVssErEP___ X +CDC7 CDC7 O00311 human LEDGF 11168 O75475 PSIP1 human S206 7231784 MVkQPCPsEsDIItE X X +CDC7 CDC7 O00311 human MCM2 17216 P97310 Mcm2 mouse S40 452311 RRADALtssPGRDLP X +CDC7 CDC7 O00311 human DBF4 10926 Q9UBU7 DBF4 human T273 1211790 QVKLRIQtDGDKyGG X +CDC7 CDC7 O00311 human RAD18 56852 Q9NS91 RAD18 human S434 17595902 IQEVLSSsESDSCNS X X +CDC7 CDC7 O00311 human MCM2 4171 P49736 MCM2 human S53 473058 LPPFEDEsEGLLGtE MCM2_N X X +CDC7 CDC7 O00311 human MCM2 4171 P49736 MCM2 human S139 454180 RRGLLyDsDEEDEER MCM2_N X X 8861; 12958 +CDC7 CDC7 O00311 human claspin 63967 Q9HAW4 CLSPN human S265 36898302 VHsFEEGsELSKGTT X +CDC7 CDC7 O00311 human MCM2 4171 P49736 MCM2 human S27 452310 GNDPLtssPGRssRR X +CDC7 CDC7 O00311 human TOP2A 7153 P11388 TOP2A human S1213 452237 QMAEVLPsPRGQRVI X X +CDC7 CDC7 O00311 human claspin 63967 Q9HAW4 CLSPN human S744 14571708 YFPTEEKsETDENsG X +CDC7 CDC7 O00311 human DTD1 92675 Q8TEA8 DTD1 human S182 36396301 AKGPsEssKERNtPR X +Rps6ka2 RSK3 Q9WUT3 mouse C/EBP-beta 24253 P21272 Cebpb rat S273 13373502 QKKVEQLsRELSTLR bZIP_2 X +TNK1 TNK1 Q13470 human TNK1 8711 Q13470 TNK1 human Y277 474456 LGGARGRyVMGGPRP PK_Tyr_Ser-Thr X 5638 +Tssk4 TSSK4 Q9D411 mouse ODF2 18286 A3KGV1 Odf2 mouse S95 4690005 CLEItPPsSEKLVSV X X +Tssk4 TSSK4 Q9D411 mouse TSSK4 71099 Q9D411 Tssk4 mouse T197 27138201 SLSHLSQtYCGSFAY Pkinase X +Tssk4 TSSK4 Q9D411 mouse CREM iso2 12916 P27699-2 Crem mouse S84 448412 EILSRRPsYRKILNE pKID X X +Map3k12 DLK Q60700 mouse MKK4 26398 P47809 Map2k4 mouse T259 447656 LVDsIAKtRDAGCRP Pkinase X 9151; 9156 +Map3k12 DLK Q60700 mouse MKK4 26398 P47809 Map2k4 mouse S255 447654 ISGQLVDsIAKtRDA Pkinase X 9156; 4514; 59056; 75450 +Rock1 ROCK1 P70335 mouse Diaphanous-3 56419 Q9Z207 Diaph3 mouse S1070 14572460 KLKDIRQsLsPMSQr X X +Rock1 ROCK1 P70335 mouse Vimentin 22352 P20152 Vim mouse S72 449026 ssAVRLRssVPGVRL Filament_head X +Rock1 ROCK1 P70335 mouse calponin 3 71994 Q9DAW9 Cnn3 mouse S293 4776192 QGtGTNGsEIsDsDy X +Rock1 ROCK1 P70335 mouse APP iso2 11820 P12023-2 App mouse S655 448200 LkkkQyTsIHHGVVE APP_amyloid X +Rock1 ROCK1 P70335 mouse FHOD1 234686 Q6P9Q4 Fhod1 mouse T1174 2035402 NRKsLRRtLKSGLGD X +Rock1 ROCK1 P70335 mouse MARCKS 17118 P26645 Marcks mouse S152 447786 kkKKKRFsFKKsFkL MARCKS X X 2741; 11992 +Rock1 ROCK1 P70335 mouse calponin 3 71994 Q9DAW9 Cnn3 mouse S296 4776198 GTNGsEIsDsDyQAE X +Rock1 ROCK1 P70335 mouse Diaphanous-3 56419 Q9Z207 Diaph3 mouse T1061 20583304 FRDRRKRtPKLKDIR X X +Rock1 ROCK1 P70335 mouse K5 110308 Q922U2 Krt5 mouse T160 900975703 PTIQRVRtEEREQIK X +Rock1 ROCK1 P70335 mouse PAR3-alpha 93742 Q99NH2 Pard3 mouse T830 2512944 QsMsEKRtkQFsDAs X +MAPK8 JNK1 iso2 P45983-2 human EWS 2130 Q01844 EWSR1 human T79 7359501 QPPTGYTtPTAPQAY X X +GSK3B GSK3B P49841 human Src 6714 P12931 SRC human S51 2420700 AdGHRGPsAAFAPAA X X +GSK3B GSK3B P49841 human ataxin-3 110616 Q9CVD2 Atxn3 mouse S29 13421402 LLQGEYFsPVELSSI Josephin X X +GSK3B GSK3B P49841 human SREBP-1 6720 P36956 SREBF1 human S434 6729302 PPPsDAGsPFQSsPL X X +GSK3B GSK3B P49841 human Tau iso8 4137 P10636-8 MAPT human T231 449079 KKVAVVRtPPKsPss X X 20473; 71429 +GSK3B GSK3B P49841 human OGT 8473 O15294 OGT human S3 27713500 _____MAssVGNVAD X X +GSK3B GSK3B P49841 human GRB14 2888 Q14449 GRB14 human S362 31834912 QGRsGCSsQSIsPMR X X +GSK3B GSK3B P49841 human PSEN1 5663 P49768 PSEN1 human S353 448562 sHLGPHRstPEsRAA Presenilin X X +GSK3B GSK3B P49841 human AHR 196 P35869 AHR human S723 1874101928 ELDYPMGsFEPsPYP X +GSK3B GSK3B P49841 human CLASP2 23122 O75122 CLASP2 human S507 481392 QGCsREAsPsRLsVA X +GSK3B GSK3B P49841 human BORA 79866 Q6PGQ7 BORA human S278 27724403 PISsPTFsPIEFQIG X X +GSK3B GSK3B P49841 human RXRA 6256 P19793 RXRA human S49 333674901 GSPGQLHsPISTLSS Nuc_recep-AF1 X +GSK3B GSK3B P49841 human Tau iso8 4137 P10636-8 MAPT human S199 447927 GDRsGyssPGsPGtP X X 29957 +GSK3B GSK3B P49841 human AHR 196 P35869 AHR human S440 1874101918 NGTsGkDsATTsTLS X +GSK3B GSK3B P49841 human C/EBP-beta 12608 P28033 Cebpb mouse T179 455887 GSsGsLStssSssPP X X +GSK3B GSK3B P49841 human ACF7 23499 Q9UPN3 MACF1 human S7314 15427027 KSAsRPGsRAGsRAG X X +GSK3B GSK3B P49841 human SEPT4 18952 P28661 Septin4 mouse S100 4705460 FSAPAPLsPSSRPRs X +GSK3B GSK3B P49841 human MNX1 15285 Q9QZW9 Mnx1 mouse S78 3191341 GDRLRAEsPsPPRLL X X +GSK3B GSK3B P49841 human Jun 3725 P05412 JUN human S243 450451 PGEtPPLsPIDMEsQ X 2994 +GSK3B GSK3B P49841 human SUFU 51684 Q9UMX1 SUFU human S342 4786843 LAHDRAPsRkDsLEs SUFU_C X +GSK3B GSK3B P49841 human Fe65 322 O00213 APBB1 human T579 288031700 SSSREQWtPSHVSVA PID X X +GSK3B GSK3B P49841 human myocardin 214384 Q8VIM5 Myocd mouse S458 3627512 HFGsTSSsPPIsPAS X X +GSK3B GSK3B P49841 human IRF3 3661 Q14653 IRF3 human T180 28095000 sPsLDNPtPFPNLGP X X +GSK3B GSK3B P49841 human AHR 196 P35869 AHR human T697 1874101926 EMDsMPYtQNFISCN X +GSK3B GSK3B P49841 human TNKS 8658 O95271 TNKS human T982 471334 SLIsPAStPSCLsAA X +GSK3B GSK3B P49841 human ERG 2078 P11308 ERG human T180 1870421703 KDDFQRLtPSyNADI SAM_PNT X X +GSK3B GSK3B P49841 human PIAS1 8554 O75925 PIAS1 human S17 53747701 MVMsLRVsELQVLLG X +GSK3B GSK3B P49841 human Tau 29477 P19332 Mapt rat S513 447928 SGyssPGsPGtPGsR X 39357; 30505 +GSK3B GSK3B P49841 human MUC1 4582 P15941 MUC1 human S1227 455675 PPsstDRsPyEKVsA X +GSK3B GSK3B P49841 human TSC2 24855 P49816 Tsc2 rat S1385 450216 FQPsQPLsKSSsSPE X X +GSK3B GSK3B P49841 human PD-L1 29126 Q9NZQ7 CD274 human S184 63237405 GkTtTTNsKREEKLF C2-set_2 X X +GSK3B GSK3B P49841 human MAFA 389692 Q8NHW3 MAFA human S61 1320401 PLStPCSsVPSsPSF X X +GSK3B GSK3B P49841 human GFI1 2672 Q99684 GFI1 human S94 41452096 EDFWRPPsPSAsPAS X X +GSK3B GSK3B P49841 human HSP70 3303 P0DMV8 HSPA1B human T636 18010647 GGsGsGPtIEEVD__ X +GSK3B GSK3B P49841 human NBR1 4077 Q14596 NBR1 human T586 33602700 HNtPVDVtPCMsPLP X X +GSK3B GSK3B P49841 human NFH 4744 P12036 NEFH human S503 455548 GGEEEtKsPPAEEAA X X +GSK3B GSK3B P49841 human DRP1 10059 O00429 DNM1L human S40 31872528 TQSSGKSsVLEsLVG Dynamin_N X X +GSK3B GSK3B P49841 human NRF2 18024 Q60795 Nfe2l2 mouse S335 18258505 MEFNDSDsGIsLNTs X X +GSK3B GSK3B P49841 human NDR1 11329 Q15208 STK38 human T7 22553317 _MAMtGstPCssMsN X X +GSK3B GSK3B P49841 human GATA6 2627 Q92908 GATA6 human S37 15419868 REPStPPsPIsSSSS X +GSK3B GSK3B P49841 human myocardin 214384 Q8VIM5 Myocd mouse S624 3627505 GQTHVLSsTFLsPQC X X +GSK3B GSK3B P49841 human CDC25A 993 P30304 CDC25A human S76 449340 SNLQRMGssEstDsG X X +GSK3B GSK3B P49841 human DROSHA 29102 Q9NRR4 DROSHA human S302 14572633 RDNRRsPsLERSYKK X +GSK3B GSK3B P49841 human ZBED3 72114 Q9D0L1 Zbed3 mouse S111 6738702 MPCPPPPsPtMAAEG X +GSK3B GSK3B P49841 human PIAS1 8554 O75925 PIAS1 human S13 53747702 ELkQMVMsLRVsELQ X +GSK3B GSK3B P49841 human PLEKHO1 67220 Q9JIY0 Plekho1 mouse S341 12739074 KAKDPPQsPPDSESE X +GSK3B GSK3B P49841 human BAX 581 Q07812 BAX human S163 469571 GGWDGLLsYFGtPTW X X +GSK3B GSK3B P49841 human FBXL20 84961 Q96IG2 FBXL20 human T417 467016 HAYFAPVtPPPsVGG X X +GSK3B GSK3B P49841 human PSF 6421 P23246 SFPQ human T687 449362 PrGMGPGtPAGyGrG X X +GSK3B GSK3B P49841 human MAFA 378435 Q8CF90 Mafa mouse T53 1320402 PPGsLSStPLStPCS X +GSK3B GSK3B P49841 human EIF6 3692 P56537 EIF6 human S235 450271 QPstIAtsMRDsLID X +GSK3B GSK3B P49841 human IL22RA1 230828 Q80XZ4 Il22ra1 mouse S414 33373903 VEDsGKDsTPGILST X X +GSK3B GSK3B P49841 human ER-alpha 2099 P03372 ESR1 human S104 448099 FPPLNsVsPsPLMLL Oest_recep X X +GSK3B GSK3B P49841 human AKAP11 11215 Q9UKA4 AKAP11 human T1136 40509053 AKEFAPAtPPStPHN X +GSK3B GSK3B P49841 human HDAC4 9759 P56524 HDAC4 human S302 17797200 APGsGPSsPNNSSGS X X +GSK3B GSK3B P49841 human Tip60 10524 Q92993 KAT5 human S86 448826 TKNGLPGsRPGsPER X X +GSK3B GSK3B P49841 human MEF2D 81518 O89038 Mef2d rat S153 10359102 VPVsNQSsMQFSNPS HJURP_C X X +GSK3B GSK3B P49841 human USF1 7391 P22415 USF1 human S186 15428820 APRTHPYsPKsEAPR X X +GSK3B GSK3B P49841 human Securin 9232 O95997 PTTG1 human S184 20764100 NLLQSPssILSTLDV Securin X X +GSK3B GSK3B P49841 human PTEN 5728 P60484 PTEN human S362 456460 SNPEASSsTSVtPDV X +GSK3B GSK3B P49841 human ACF7 23499 Q9UPN3 MACF1 human S7222 18507012 FRsRGRRsKPSsRAA X X +GSK3B GSK3B P49841 human STAT2 6773 P52630 STAT2 human S393 1869778702 LtPEKGQsQGLIWDF STAT_bind X X +GSK3B GSK3B P49841 human 5-HT(1B) 15551 P28334 Htr1b mouse S154 10897604 ITDAVEYsAKRtPKR 7tm_1 X +GSK3B GSK3B P49841 human SQLE 6713 Q14534 SQLE human S87 1877421602 WAKsPPEsENkEQLE X X +GSK3B GSK3B P49841 human SPAG5 10615 Q96R06 SPAG5 human T978 1261101 AEMsIMTtELQSLCS X X +GSK3B GSK3B P49841 human ZNF281 23528 Q9Y2X9 ZNF281 human S638 31881319 PRVDLHtsGEHsELV X X +GSK3B GSK3B P49841 human p21Cip1 1026 P38936 CDKN1A human S114 478191 EEDHVDLsLSCTLVP X X +GSK3B GSK3B P49841 human FOXP3 50943 Q9BZS1 FOXP3 human S270 56786300 kMALTkAsSVAssDK X +GSK3B GSK3B P49841 human RFX1 5989 P22670 RFX1 human T124 31871835 sEAsPGStAsQTGVP X +GSK3B GSK3B P49841 human HSP90B 3326 P08238 HSP90AB1 human S718 3177650 LEGDEDAsRMEEVD_ X +GSK3B GSK3B P49841 human MCL1 4170 Q07820 MCL1 human S159 460683 NNtStDGsLPstPPP X X +GSK3B GSK3B P49841 human Tau 29477 P19332 Mapt rat S510 447927 GERSGyssPGsPGtP X 29957 +GSK3B GSK3B P49841 human CCNE1 898 P24864 CCNE1 human S73 2585500 AVCADPCsLIPtPDK X +GSK3B GSK3B P49841 human myocardin 214384 Q8VIM5 Myocd mouse S628 3627510 VLSsTFLsPQCsPQH X X +GSK3B GSK3B P49841 human GYS1 2997 P13807 GYS1 human S641 448237 yRyPRPAsVPPsPsL Glycogen_syn X 3891; 98074; 47043 +GSK3B GSK3B P49841 human ZAP 252832 Q8K3Y6 Zc3hav1 rat S279 3203922 PPsPDVTsCKDsLED X +GSK3B GSK3B P49841 human CLASP2 23122 O75122 CLASP2 human S499 22349877 KRsKIPRsQGCsREA X +GSK3B GSK3B P49841 human RASSF1 iso2 11186 Q9NS23-2 RASSF1 human S178 13258705 VRPVsVPssKKPPsL X +GSK3B GSK3B P49841 human desmin 1674 P17661 DES human S32 466343 PLGsPLssPVFPrAG Filament_head X +GSK3B GSK3B P49841 human PDX1 29535 P52947 Pdx1 rat S268 11279404 LPSGLSAsPQPsSIA X X +GSK3B GSK3B P49841 human CTNNB1 1499 P35222 CTNNB1 human S37 447582 yLDsGIHsGATtTAP X X 9561; 2009; 4270; 13537; 41334; 60180 +GSK3B GSK3B P49841 human RASSF1 iso2 11186 Q9NS23-2 RASSF1 human S175 13258707 LKLVRPVsVPssKKP X +GSK3B GSK3B P49841 human VDAC1 7416 P21796 VDAC1 human T107 3181799 DssFsPNtGkkNAKI Porin_3 X +GSK3B GSK3B P49841 human AMPKA1 5562 Q13131 PRKAA1 human T482 3195164 RSIDDEItEAksGtA AdenylateSensor X X +GSK3B GSK3B P49841 human PHLPP 23239 O60346 PHLPP1 human S1379 22769302 GSKGLWDsLsVEEAV PP2C X +GSK3B GSK3B P49841 human CDH1 12550 P09803 Cdh1 mouse S849 465568 sEAAsLssLNSsEsD CADH_Y-type_LIR X +GSK3B GSK3B P49841 human FBXL21 213311 Q8BFZ4 Fbxl21 mouse S37 1880462804 LRQtHALsVLLDWGT X +GSK3B GSK3B P49841 human GLE1 2733 Q53GS7 GLE1 human S99 18010022 ssAFsPAsPAtPNGT X +GSK3B GSK3B P49841 human MAFA 378435 Q8CF90 Mafa mouse S65 5403102 PCSsVPSsPSFCAPS X +GSK3B GSK3B P49841 human FBXL20 84961 Q96IG2 FBXL20 human S251 1875005604 RGCHKLQsLCAsGCS X X +GSK3B GSK3B P49841 human TNKS 8658 O95271 TNKS human S991 471336 SCLsAASsIDNLTGP X +GSK3B GSK3B P49841 human Snail2 6591 O43623 SNAI2 human S96 25603908 PPPsDTSsKDHsGSE X X +GSK3B GSK3B P49841 human SPAG5 10615 Q96R06 SPAG5 human S974 1261100 EESLAEMsIMTtELQ X X +GSK3B GSK3B P49841 human AMPKA1 5562 Q13131 PRKAA1 human S486 3195155 DEItEAksGtAtPQR AdenylateSensor X X +GSK3B GSK3B P49841 human SOX2 6657 P48431 SOX2 human S251 6738002 VksEAsssPPVVtSS X X 92186 +GSK3B GSK3B P49841 human Tau iso8 4137 P10636-8 MAPT human S396 449081 GAEIVyKsPVVsGDt X X 9632 +GSK3B GSK3B P49841 human p53 7157 P04637 TP53 human S376 447570 LkskkGQstsRHkkL X +GSK3B GSK3B P49841 human FBXL20 84961 Q96IG2 FBXL20 human S255 1875005606 KLQsLCAsGCSNITD X X +GSK3B GSK3B P49841 human MYBPC3 4607 Q14896 MYBPC3 human S304 471081 SLLKKRDsFRtPRDs X +GSK3B GSK3B P49841 human IL17RA 16172 Q60943 Il17ra mouse T779 41452470 EVVLEGCtPSEEEQR X +GSK3B GSK3B P49841 human E2F1 1869 Q01094 E2F1 human T433 447871 DCDFGDLtPLDF___ X +GSK3B GSK3B P49841 human Tau iso8 4137 P10636-8 MAPT human S404 449082 PVVsGDtsPRHLsNV X X 35834; 20194; 98523; 91600; 49562 +GSK3B GSK3B P49841 human DRP1 10059 O00429 DNM1L human S44 31866197 GKSsVLEsLVGRDLL Dynamin_N X X +GSK3B GSK3B P49841 human BCLAF1 9774 Q9NYF8 BCLAF1 human S531 455195 KstFREEsPLRIkMI THRAP3_BCLAF1 X +GSK3B GSK3B P49841 human MITF iso9 4286 O75030-9 MITF human S298 448503 QARAHGLsLIPSTGL DUF3371 X +GSK3B GSK3B P49841 human MAFA 389692 Q8NHW3 MAFA human T57 456028 LSStPLStPCSsVPS X X +GSK3B GSK3B P49841 human Raptor 57521 Q8N122 RPTOR human S792 2314600 DKMRRAssYSsLNSL X 2083; 89146 +GSK3B GSK3B P49841 human smMLCK 396445 P11799 MYLK chicken S1765 468781 GRKAsGssPTsPINA X +GSK3B GSK3B P49841 human ACF7 23499 Q9UPN3 MACF1 human S7318 18507010 RPGsRAGsRAGsRAs X X +GSK3B GSK3B P49841 human SOX9 6662 P48436 SOX9 human T236 40722389 GQSQGPPtPPtTPKT X +GSK3B GSK3B P49841 human PR iso2 5241 P06401-2 PGR human S390 11273301 PDSEASQsPQYsFES Prog_receptor X X +GSK3B GSK3B P49841 human CdGAP 12549 A6X8Z5 Arhgap31 mouse T776 456517 tPAPPPPtPLEEEPE X X +GSK3B GSK3B P49841 human CTNNB1 1499 P35222 CTNNB1 human S45 447488 GATtTAPsLsGkGNP X 9565; 9564; 24710; 70034; 19807; 96727; 77605 +GSK3B GSK3B P49841 human Tau iso8 4137 P10636-8 MAPT human S262 447930 NVKskIGstENLkHQ Tubulin-binding X X +GSK3B GSK3B P49841 human myocardin 214384 Q8VIM5 Myocd mouse S462 3627507 TSSsPPIsPASsDLS X X +GSK3B GSK3B P49841 human DYN1 140694 P21575 Dnm1 rat S774 450205 SVPAGRRsPTSsPTP X X +GSK3B GSK3B P49841 human CABYR 26256 O75952 CABYR human T151 11454101 PATPKTTtPPSsPPP X +GSK3B GSK3B P49841 human ENDOG 2021 Q14249 ENDOG human S288 1871762500 NILARAGsLkAITAG X X +GSK3B GSK3B P49841 human CAP1 10487 Q01518 CAP1 human S310 2525971 PKPQtsPsPkRAtKk X +GSK3B GSK3B P49841 human CLASP2 23122 O75122 CLASP2 human S537 22648007 REAsREssRDTsPVR X X +GSK3B GSK3B P49841 human Raptor 57521 Q8N122 RPTOR human S877 3205938 HIHQAGGsPPAssts X +GSK3B GSK3B P49841 human GSK3B 2932 P49841 GSK3B human Y216 448569 RGEPNVsyICsRyyR Pkinase X X +GSK3B GSK3B P49841 human GCM1 8521 Q9NP62 GCM1 human S322 7979600 NYPFPLTsWPCsFSP X X +GSK3B GSK3B P49841 human myocardin 214384 Q8VIM5 Myocd mouse S454 3627508 TGFYHFGsTSSsPPI X X +GSK3B GSK3B P49841 human ULK1 22241 O70405 Ulk1 mouse S415 4958506 CSSSPSPsGRPGPFS X +GSK3B GSK3B P49841 human DNMT1 1786 P26358 DNMT1 human S714 452655 DNIPEMPsPkKMHQG X X +GSK3B GSK3B P49841 human C/EBP-delta 1052 P49716 CEBPD human T171 28852501 PRSsPRQtPAPGPAR X +GSK3B GSK3B P49841 human LRP6 4040 O75581 LRP6 human S1490 456289 AILNPPPsPAtERsH X X 2568 +GSK3B GSK3B P49841 human KLC2 64837 Q9H0B6 KLC2 human S608 4693027 LsDSRtLssssMDLs X +GSK3B GSK3B P49841 human MAFA 389692 Q8NHW3 MAFA human S49 1320400 CHRLPPGsLSStPLS X X +GSK3B GSK3B P49841 human SREBP-1 iso1 78968 P56720-1 Srebf1 rat S73 14580856 KVTPAPLsPPPSAPT X +GSK3B GSK3B P49841 human RICTOR 253260 Q6R327 RICTOR human T1695 40638601 EAEAVLAtPPKQPIV X +GSK3B GSK3B P49841 human FBXL20 84961 Q96IG2 FBXL20 human S139 1875005600 DATCTSLskFCsKLR X X +GSK3B GSK3B P49841 human EB1 22919 Q15691 MAPRE1 human S156 1259758900 PkkPLtssSAAPQRP X +GSK3B GSK3B P49841 human Snail1 6615 O95863 SNAI1 human S119 6097706 sFSsTSVsSLEAEAY X X +GSK3B GSK3B P49841 human eIF2B-epsilon 192234 Q64350 Eif2b5 rat S535 449905 VDPEELDsRAGsPQL X +GSK3B GSK3B P49841 human APP 54226 P08592 App rat T743 448523 VEVDAAVtPEERHLS APP_amyloid X 3823; 6986 +GSK3B GSK3B P49841 human IKKG 8517 Q9Y6K9 IKBKG human S43 449037 PAMLHLPsEQGAPEt X +GSK3B GSK3B P49841 human FBXL21 213311 Q8BFZ4 Fbxl21 mouse T33 1870414702 LCSSLRQtHALsVLL X +GSK3B GSK3B P49841 human Myc 4609 P01106 MYC human T73 448496 kkFELLPtPPLsPsR Myc_N X X 46650 +GSK3B GSK3B P49841 human SOX4 20677 Q06831 Sox4 mouse S315 50800249 SGRSSAAssPAASRS X +GSK3B GSK3B P49841 human CDX2 1045 Q99626 CDX2 human S283 456208 RsVPEPLsPVSSLQA X +GSK3B GSK3B P49841 human CTPS 1503 P17812 CTPS1 human S571 457565 RDtysDrsGsssPDs X X +GSK3B GSK3B P49841 human ZBED3 72114 Q9D0L1 Zbed3 mouse T113 6738703 CPPPPsPtMAAEGDW X +GSK3B GSK3B P49841 human CRMP-4 1809 Q14195 DPYSL3 human T514 458798 tttPkGGtPAGsArG X X +GSK3B GSK3B P49841 human SERCA2 488 P16615 ATP2A2 human S663 452253 EFDELNPsAQRDACL X +GSK3B GSK3B P49841 human PHLPP 23239 O60346 PHLPP1 human T1363 22769303 HVQsVLLtPQDEFFI PP2C X +GSK3B GSK3B P49841 human USF1 7391 P22415 USF1 human T153 463815 EALLGQAtPPGTGQF X X +GSK3B GSK3B P49841 human C/EBP-beta 12608 P28033 Cebpb mouse S184 455886 LStssSssPPGtPSP X +GSK3B GSK3B P49841 human ACF7 23499 Q9UPN3 MACF1 human S7322 18507008 RAGsRAGsRAssRRG X X +GSK3B GSK3B P49841 human Tau iso8 4137 P10636-8 MAPT human T153 449076 DGKtKIAtPRGAAPP X +GSK3B GSK3B P49841 human Tau iso3 4137 P10636-3 MAPT human S199 449328 KVTSKCGsLGNIHHK Tubulin-binding X +GSK3B GSK3B P49841 human Src 6714 P12931 SRC human S43 31885161 QtPsKPAsAdGHRGP X +GSK3B GSK3B P49841 human PKCE 5581 Q02156 PRKCE human S346 2807904 sEEDRsKsAPtsPCD X X +GSK3B GSK3B P49841 human PR iso2 5241 P06401-2 PGR human S164 28706301 RQLLEDEsYDGGAGA Prog_receptor X +GSK3B GSK3B P49841 human GYS1 100008660 P13834 GYS1 rabbit S645 448238 RPAsVPPsPSLsRHS Glycogen_syn X +GSK3B GSK3B P49841 human SERCA2 11938 O55143 Atp2a2 mouse S663 452253 EFDELsPsAQRDACL X +GSK3B GSK3B P49841 human HRas 3265 P01112 HRAS human T144 25324400 yGIPYIEtsAktRQG Ras X X +GSK3B GSK3B P49841 human FCAR 2204 P24071 FCAR human S284 1870031100 LTFARTPsVCK____ X +GSK3B GSK3B P49841 human PDX1 18609 P52946 Pdx1 mouse S66 458402 QGsPPDIsPYEVPPL X +GSK3B GSK3B P49841 human NIFK 84365 Q9BYG3 NIFK human S230 457632 tPEKtVDsQGPtPVC hNIFK_binding X +GSK3B GSK3B P49841 human CREB 1385 P16220 CREB1 human S115 450092 QKRREILsRRPsyRk pKID X +GSK3B GSK3B P49841 human MITF iso9 4286 O75030-9 MITF human S405 31858102 PGAsKTSsRRSsMSM DUF3371 X +GSK3B GSK3B P49841 human STAT3 6774 P40763 STAT3 human S727 448191 NtIDLPMsPrTLDSL X X 9134; 9136; 34911; 94994; 49081; 58978; 87544; 71958; 50804 +GSK3B GSK3B P49841 human LPCAT1 210992 Q3TFD2 Lpcat1 mouse S182 17533101 VSRsDQDsRRKTVEE Acyltransferase X +GSK3B GSK3B P49841 human RBM38 55544 Q9H0Z9 RBM38 human S195 29606707 DQYPYAAsPATAASF X X +GSK3B GSK3B P49841 human RELB 5971 Q01201 RELB human S573 450233 AFGGGLLsPGPEAt_ RelB_transactiv X 4999; 13567; 5025; 17616 +GSK3B GSK3B P49841 human IRF1 16362 P15314 Irf1 mouse T181 1380568700 LDMERDItPALsPCV X +GSK3B GSK3B P49841 human MCL1 4170 Q07820 MCL1 human S121 1172400 PAADAIMsPEEELDG X +GSK3B GSK3B P49841 human NFkB-p65 5970 Q04206 RELA human S468 451145 AVFTDLAsVDNsEFQ X X 3039 +GSK3B GSK3B P49841 human GR 14815 P06537 Nr3c1 mouse S421 5044100 GMRPDVSsPPSSSST X +GSK3B GSK3B P49841 human FOXP3 50943 Q9BZS1 FOXP3 human S274 34370255 TkAsSVAssDKGSCC X +GSK3B GSK3B P49841 human PDX1 29535 P52947 Pdx1 rat S272 11279403 LSAsPQPsSIAPLRP X +GSK3B GSK3B P49841 human CRMP-2 1808 Q16555 DPYSL2 human T509 448083 PVCEVsVtPktVtPA X +GSK3B GSK3B P49841 human CRMP-2 1808 Q16555 DPYSL2 human T514 454386 sVtPktVtPAssAkt X X 9397 +GSK3B GSK3B P49841 human C/EBP-beta 1051 P17676 CEBPB human S223 2902801 VPsGSSGsLsTSSss X +GSK3B GSK3B P49841 human MAFA 378435 Q8CF90 Mafa mouse S49 1320400 CHRLPPGsLSStPLS X +GSK3B GSK3B P49841 human SRF 6722 P11831 SRF human S224 468829 TCLNsPDsPPRsDPT X +GSK3B GSK3B P49841 human ZAP 252832 Q8K3Y6 Zc3hav1 rat S257 469059 RDRFLHNsLEFLsPV X X +GSK3B GSK3B P49841 human desmin 1674 P17661 DES human S28 4705787 APGFPLGsPLssPVF Filament_head X +GSK3B GSK3B P49841 human desmin Q5XFN2 DES dog S32 466343 PLGsPLGsPVFPRAG Filament_head X +GSK3B GSK3B P49841 human CCND1 595 P24385 CCND1 human T286 447839 EEVDLACtPtDVRDV X X 3300; 94159 +GSK3B GSK3B P49841 human FBXL20 84961 Q96IG2 FBXL20 human S425 4149424 PPPsVGGsRQRFCRC X X +GSK3B GSK3B P49841 human Bcl-xL 598 Q07817 BCL2L1 human S62 449099 PSWHLADsPAVNGAT X +GSK3B GSK3B P49841 human NRF2 4780 Q16236 NFE2L2 human S347 18258501 NDSDsGIsLNTsPSV X X +GSK3B GSK3B P49841 human L-Myc 4610 P12524 MYCL human S38 448140 KKFELVPsPPtsPPW Myc_N X +GSK3B GSK3B P49841 human Snail1 6615 O95863 SNAI1 human S100 6097704 DEDsGkGsQPPsPPs X X +GSK3B GSK3B P49841 human OSBP2 23762 Q969R2 OSBP2 human S762 11171320 ECSKVMHssPssPsS Oxysterol_BP X +GSK3B GSK3B P49841 human H1B 3009 P16401 H1-5 human T11 458351 tAPAEtAtPAPVEks X X +GSK3B GSK3B P49841 human AKAP11 11215 Q9UKA4 AKAP11 human T1140 41313700 APAtPPStPHNSSVG X +GSK3B GSK3B P49841 human GYS1 2997 P13807 GYS1 human S653 448240 PsLsRHssPHQsEDE Glycogen_syn X +GSK3B GSK3B P49841 human MITF iso9 4286 O75030-9 MITF human S401 11125701 SSVsPGAsKTSsRRS DUF3371 X +GSK3B GSK3B P49841 human UNG 7374 P13051 UNG human S64 2018601 EPGtPPssPLsAEQL X +GSK3B GSK3B P49841 human OGT 8473 O15294 OGT human S4 27713501 ____MAssVGNVADS X X +GSK3B GSK3B P49841 human PSD-95 29495 P31016 Dlg4 rat T19 3609101 YRYQDEDtPPLEHSP X +GSK3B GSK3B P49841 human PICK1 9463 Q9NRD5 PICK1 human S342 25749628 QRLVsTMsKYYNDCy Arfaptin X +GSK3B GSK3B P49841 human APC 324 P25054 APC human S1501 999605 ESTPDGFsCsssLsA APC_r X +GSK3B GSK3B P49841 human CTNNB1 12387 Q02248 Ctnnb1 mouse T41 447583 GIHsGATtTAPsLsG X 9561; 9565; 4270; 13537; 41334; 60180 +GSK3B GSK3B P49841 human ACF7 23499 Q9UPN3 MACF1 human S7226 18507015 GRRsKPSsRAAsPTR X X +GSK3B GSK3B P49841 human BMAL1 406 O00327 BMAL1 human T21 12575204 DFMsPGPtDLLSSSL X X +GSK3B GSK3B P49841 human STMN3 50861 Q9NZ72 STMN3 human S60 4698871 sFEVILksPSDLsPE Stathmin X +GSK3B GSK3B P49841 human E2F1 1869 Q01094 E2F1 human S403 447870 PEEFISLsPPHEALD X +GSK3B GSK3B P49841 human RAPH1 65059 Q70E73 RAPH1 human S1071 1883958002 FPsPPsDsDFPPPPP X +GSK3B GSK3B P49841 human CRMP-4 25418 Q62952 Dpysl3 rat T509 454328 PVFDLTTtPKGGtPA X +GSK3B GSK3B P49841 human RFX1 5989 P22670 RFX1 human S120 452650 SETVsEAsPGStAsQ X +GSK3B GSK3B P49841 human SREBP-1 6720 P36956 SREBF1 human T426 467200 TEVEDTLtPPPsDAG X X +GSK3B GSK3B P49841 human CLOCK 9575 O15516 CLOCK human S427 7911903 ALERFDHsPtPsASs X +GSK3B GSK3B P49841 human MAP2 iso3 25595 P15146-3 Map2 rat T259 450181 YSSRTPGtPGtPSYP X +GSK3B GSK3B P49841 human CCND3 896 P30281 CCND3 human T283 452160 QGPsQtstPtDVtAI X X 53966 +GSK3B GSK3B P49841 human GYS1 14936 Q9Z1E4 Gys1 mouse S641 448237 YRyPRPAsVPPsPsL Glycogen_syn X 3891; 98074; 47043 +GSK3B GSK3B P49841 human RCAN1 1827 P53805 RCAN1 human S163 456022 PDKQFLIsPPAsPPV Calcipressin X +GSK3B GSK3B P49841 human OSBP2 23762 Q969R2 OSBP2 human S766 15721694 VMHssPssPsSDGKQ Oxysterol_BP X +GSK3B GSK3B P49841 human UNG 7374 P13051 UNG human T60 452622 AGQEEPGtPPssPLs X X +GSK3B GSK3B P49841 human ADD2 119 P35612 ADD2 human S693 454590 SVTSGPMsPEGsPsK X +GSK3B GSK3B P49841 human MOB1A 232157 Q921Y0 Mob1a mouse S146 1214257701 PFPKNFMsVAKTILK Mob1_phocein X +GSK3B GSK3B P49841 human FBXL20 84961 Q96IG2 FBXL20 human S143 1875005602 TSLskFCsKLRHLDL LRR_6 X X +GSK3B GSK3B P49841 human Tau iso8 4137 P10636-8 MAPT human S409 449132 DtsPRHLsNVsstGs X +GSK3B GSK3B P49841 human Snail1 6615 O95863 SNAI1 human S107 455882 sQPPsPPsPAPssFS X X +GSK3B GSK3B P49841 human GYS1 100008660 P13834 GYS1 rabbit S653 448240 PSLsRHSsPHQsEDE Glycogen_syn X +GSK3B GSK3B P49841 human IKKG 8517 Q9Y6K9 IKBKG human S8 62382604 MNRHLWKsQLCEMVQ X X +GSK3B GSK3B P49841 human WT1 iso7 7490 P19544-7 WT1 human S69 1871128701 RsRGAsGsEPQQMGs X +GSK3B GSK3B P49841 human FAK 396416 Q00944 PTK2 chicken S722 447962 PSRPGYPsPRSsEGF X X +GSK3B GSK3B P49841 human IL1RL1 17082 P14719 Il1rl1 mouse S442 25585004 AATVVESsIQNsRRQ TIR X +GSK3B GSK3B P49841 human GLE1 2733 Q53GS7 GLE1 human T102 472369 FsPAsPAtPNGTKGk X +GSK3B GSK3B P49841 human PSEN1 5663 P49768 PSEN1 human S357 448563 PHRstPEsRAAVQEL Presenilin X X +GSK3B GSK3B P49841 human DROSHA 29102 Q9NRR4 DROSHA human S300 14572630 RHRDNRRsPsLERSY X +GSK3B GSK3B P49841 human RAPH1 65059 Q70E73 RAPH1 human S1069 1883958000 VEFPsPPsDsDFPPP X +GSK3B GSK3B P49841 human BMAL1 406 O00327 BMAL1 human S17 12575203 STISDFMsPGPtDLL X X +GSK3B GSK3B P49841 human PPP1R16B 282091 Q95N27 PPP1R16B cow S333 486244 LRHKSSLsRRTsSAG X +GSK3B GSK3B P49841 human NR1D1 9572 P20393 NR1D1 human S59 471092 FPPsPTGsLTQDPAR X X 2129 +GSK3B GSK3B P49841 human STAT3 6774 P40763 STAT3 human T714 3190177 ktKFICVtPTtCsNt X X +GSK3B GSK3B P49841 human STAT2 6773 P52630 STAT2 human T385 1869778701 ILTsNQktLtPEKGQ STAT_bind X X +GSK3B GSK3B P49841 human L-Myc 4610 P12524 MYCL human S42 448141 LVPsPPtsPPWGLGP Myc_N X +GSK3B GSK3B P49841 human CRMP-2 1808 Q16555 DPYSL2 human S518 448081 ktVtPAssAktsPAk X X +GSK3B GSK3B P49841 human SMAD4 4089 Q13485 SMAD4 human T265 36694101 ATYHHNStTTWtGSR X +GSK3B GSK3B P49841 human SPAG5 10615 Q96R06 SPAG5 human T111 460413 PIPQIsStPkTsEEA X X +GSK3B GSK3B P49841 human SNCA 6622 P37840 SNCA human S129 448278 NEAyEMPsEEGyQDy Synuclein X X 23706; 87281 +GSK3B GSK3B P49841 human N-Myc 4613 P04198 MYCN human T58 448223 KkFELLPtPPLsPsr Myc_N X 46650 +GSK3B GSK3B P49841 human IRF3 3661 Q14653 IRF3 human S123 4712212 DFSQPDTsPDTNGGG X X +GSK3B GSK3B P49841 human XIAP 331 P98170 XIAP human T180 3801500 WPDYAHLtPRELASA BIR X +GSK3B GSK3B P49841 human SP1 6667 P08047 SP1 human S728 2535904 VGtLPLDsGAGsEGS X +GSK3B GSK3B P49841 human CRMP-2 25416 P47942 Dpysl2 rat T514 454386 SVtPKTVtPASsAKT X X 9397 +GSK3B GSK3B P49841 human BLM 641 P54132 BLM human T171 471430 ETSksFVtPPQsHFV BLM_N X +GSK3B GSK3B P49841 human Tau iso8 4137 P10636-8 MAPT human S46 447926 tDAGLkEsPLQtPtE X 20296 +GSK3B GSK3B P49841 human PDX1 18609 P52946 Pdx1 mouse S61 458401 LGSLEQGsPPDIsPY X +GSK3B GSK3B P49841 human FRAT1 10023 Q92837 FRAT1 human S188 471366 RLQQRRGsQPETRTG GSK-3_bind X +GSK3B GSK3B P49841 human ZAP 252832 Q8K3Y6 Zc3hav1 rat S288 4776633 KDsLEDVsVDVTQKF X +GSK3B GSK3B P49841 human CTNNB1 12387 Q02248 Ctnnb1 mouse S33 447487 QQQsYLDsGIHsGAT X 9561; 2009; 4270; 13537; 41334; 60180 +GSK3B GSK3B P49841 human NFAT1 18019 Q60591 Nfatc2 mouse S215 447845 QNIPAHYsPRtsPIM X +GSK3B GSK3B P49841 human MAFA 389692 Q8NHW3 MAFA human T53 1320402 PPGsLSStPLStPCS X X +GSK3B GSK3B P49841 human neurogenin 3 11925 P70661 Neurog3 mouse S183 35527103 VSQAGNLsPTAsLEE X +GSK3B GSK3B P49841 human AMPKA1 5562 Q13131 PRKAA1 human T490 3195170 EAksGtAtPQRsGsV AdenylateSensor X X +GSK3B GSK3B P49841 human TOP2A 7153 P11388 TOP2A human S1361 455094 sPPKTKtsPKLsNkE X +GSK3B GSK3B P49841 human Raptor 57521 Q8N122 RPTOR human S859 2024885 DtssLtQsAPAsPtN X +GSK3B GSK3B P49841 human 4E-BP1 1978 Q13541 EIF4EBP1 human S65 447527 FLMECrNsPVtktPP eIF_4EBP X 9451; 9456; 13443 +GSK3B GSK3B P49841 human FBXL21 26223 Q9UKT6 FBXL21P human T33 1870414702 FYSSLNQtHTHTVLL X X +GSK3B GSK3B P49841 human NDR1 11329 Q15208 STK38 human S6 22553318 __MAMtGstPCssMs X X +GSK3B GSK3B P49841 human AHR 196 P35869 AHR human S727 1874101930 PMGsFEPsPYPtTSS X +GSK3B GSK3B P49841 human Lu 4059 P50895 BCAM human S596 1713902 PPGEPGLsHsGsEQP X +GSK3B GSK3B P49841 human ACF7 23499 Q9UPN3 MACF1 human S7330 468158 RAssRRGsDAsDFDL X X +GSK3B GSK3B P49841 human NFkB-p100 4791 Q00653 NFKB2 human S711 25234803 PLPsPPTsDsDsDsE X +GSK3B GSK3B P49841 human FOXL2 668 P58012 FOXL2 human S33 21697903 EPEGPPPsPGKGGGG X X +GSK3B GSK3B P49841 human Tau 29477 P19332 Mapt rat S707 449081 GAEIVyKsPVVsGDt X 9632 +GSK3B GSK3B P49841 human TSC2 24855 P49816 Tsc2 rat S1377 469993 ARPtVDLsFQPsQPL X X +GSK3B GSK3B P49841 human Tau iso8 4137 P10636-8 MAPT human S202 447928 sGyssPGsPGtPGsR X X 39357; 30505 +GSK3B GSK3B P49841 human Telethonin 8557 O15273 TCAP human S157 448693 GALRRsLsRSMsQEA Telethonin X X +GSK3B GSK3B P49841 human Snail1 6615 O95863 SNAI1 human S104 455881 GkGsQPPsPPsPAPs X X +GSK3B GSK3B P49841 human FTO 26383 Q8BGW1 Fto mouse S249 1115398000 YSYsCEGsEDEsEDE FTO_NTD X +GSK3B GSK3B P49841 human SOX11 20666 Q7M6Y2 Sox11 mouse S244 454322 SVAKVPAsPTLSSAA X +GSK3B GSK3B P49841 human SCN8A 29710 O88420 Scn8a rat T1936 1040254701 HRDKKEStPSTASLP X +GSK3B GSK3B P49841 human STAT2 6773 P52630 STAT2 human S381 1869778700 RkFNILTsNQktLtP STAT_bind X X +GSK3B GSK3B P49841 human ZAP 252832 Q8K3Y6 Zc3hav1 rat S262 1870336230 HNsLEFLsPVVsPLG X X +GSK3B GSK3B P49841 human NHE3 100009430 P26432 NHE-3 rabbit S526 31839902 MRQsAQKsRDRILNV X +GSK3B GSK3B P49841 human ER-alpha 2099 P03372 ESR1 human S102 449799 GGFPPLNsVsPsPLM Oest_recep X X +GSK3B GSK3B P49841 human SQLE 6713 Q14534 SQLE human S83 1877421600 IGFFWAKsPPEsENk X X +GSK3B GSK3B P49841 human RASSF1 iso2 11186 Q9NS23-2 RASSF1 human S179 13258706 RPVsVPssKKPPsLQ X +GSK3B GSK3B P49841 human SIK 59329 Q9R1U5 Sik1 rat T182 456034 KPGEPLStWCGsPPY Pkinase X +GSK3B GSK3B P49841 human IRS1 25467 P35570 Irs1 rat S332 455323 sDGEGTMsRPAsVDG X X 2580 +GSK3B GSK3B P49841 human SREBP-1 6720 P36956 SREBF1 human S430 467201 DTLtPPPsDAGsPFQ X X +GSK3B GSK3B P49841 human desmin Q5XFN2 DES dog S28 4705787 AGGFPLGsPLGsPVF Filament_head X +GSK3B GSK3B P49841 human GRB14 2888 Q14449 GRB14 human S358 31834913 MHPYQGRsGCSsQSI X X +GSK3B GSK3B P49841 human CEACAM1 634 P13688 CEACAM1 human S508 448536 QQPTQPTsAsPsLTA X +GSK3B GSK3B P49841 human ZAP 252832 Q8K3Y6 Zc3hav1 rat S270 3203916 PVVsPLGsGPPsPDV X X +GSK3B GSK3B P49841 human ER-alpha 2099 P03372 ESR1 human S118 448101 LHPPPQLsPFLQPHG Oest_recep X X 2511 +GSK3B GSK3B P49841 human Tau iso8 4137 P10636-8 MAPT human S400 449130 VyKsPVVsGDtsPRH X X 35834; 20194; 98523; 91600; 49562 +GSK3B GSK3B P49841 human neurogenin 3 11925 P70661 Neurog3 mouse S187 35527102 GNLsPTAsLEEFPGL X +GSK3B GSK3B P49841 human TNKS 8658 O95271 TNKS human S978 471333 VVSASLIsPAStPSC X +GSK3B GSK3B P49841 human neurogenin 2 11924 P70447 Neurog2 mouse S231 2255101 SPYSCTLsPAsPGSD X +GSK3B GSK3B P49841 human ZAP 252832 Q8K3Y6 Zc3hav1 rat S274 3203919 PLGsGPPsPDVTsCK X X +GSK3B GSK3B P49841 human JunB 3726 P17275 JUNB human T255 465822 EARsRDAtPPVsPIN Jun X +GSK3B GSK3B P49841 human RAPH1 65059 Q70E73 RAPH1 human T1123 1883958004 VKKAPPPtRPKRNDs X +GSK3B GSK3B P49841 human FTO 26383 Q8BGW1 Fto mouse S253 27449492 CEGsEDEsEDEsSFE FTO_NTD X +GSK3B GSK3B P49841 human PU.1 6688 P17947 SPI1 human S41 13421401 EYYPYLSsDGESHSD X X +GSK3B GSK3B P49841 human Desmoplakin 1832 P15924 DSP human S2845 40416402 RsGsRsGsRRGsFDA X +GSK3B GSK3B P49841 human GRB14 2888 Q14449 GRB14 human S370 14567758 QSIsPMRsIsENsLV BPS X +GSK3B GSK3B P49841 human OLIG2 50913 Q9EQW6 Olig2 mouse S10 18357903 SDASLVSsRPssPEP X +GSK3B GSK3B P49841 human PTEN 5728 P60484 PTEN human T366 449634 ASSsTSVtPDVsDNE X X +GSK3B GSK3B P49841 human C/EBP-beta 24253 P21272 Cebpb rat T189 447878 SSSsPPGtPSPADAK X X 3084 +GSK3B GSK3B P49841 human CIITA 4261 P33076 CIITA human S373 1295502 VQARLERsSSKSLER X +GSK3B GSK3B P49841 human WT1 iso7 7490 P19544-7 WT1 human S67 56653434 GRRsRGAsGsEPQQM X +GSK3B GSK3B P49841 human ER-alpha 2099 P03372 ESR1 human S106 448100 PLNsVsPsPLMLLHP Oest_recep X X +GSK3B GSK3B P49841 human hnRNP D0 3184 Q14103 HNRNPD human S83 449336 DEGHsNssPRHsEAA X +GSK3B GSK3B P49841 human LPCAT1 210992 Q3TFD2 Lpcat1 mouse S178 17533100 RPVFVSRsDQDsRRK Acyltransferase X +GSK3B GSK3B P49841 human EGLN2 112398 Q96KS0 EGLN2 human S401 62873403 KGVQVPVsQPPtPT_ X +GSK3B GSK3B P49841 human PAX3 18505 P24610 Pax3 mouse S201 18744500 ERASAPQsDEGsDID X +GSK3B GSK3B P49841 human GRB14 2888 Q14449 GRB14 human S423 62887802 THGsPtAsSQSSATN X +GSK3B GSK3B P49841 human GSK3B 2932 P49841 GSK3B human S9 449111 SGRPRttsFAEsCkP X 9336; 9331; 9327; 9323; 9322; 9325; 5558; 8566; 79774; 8466; 25462; 14026; 14332; 14310; 14630 +GSK3B GSK3B P49841 human FANCL 55120 Q9NW38 FANCL human T178 63128909 VPFCASWtPQSSLIS FANCL_d2 X +GSK3B GSK3B P49841 human NFAT1 18019 Q60591 Nfatc2 mouse S223 447847 PRtsPIMsPRTsLAE X +GSK3B GSK3B P49841 human CTNND2 18163 O35927 Ctnnd2 mouse T1078 2020381 RPySSSRtPsIsPVR X X +GSK3B GSK3B P49841 human PKM 5315 P14618 PKM human T328 481749 GkPVICAtQMLESMI PK X X +GSK3B GSK3B P49841 human CTNNB1 12387 Q02248 Ctnnb1 mouse S37 447582 YLDsGIHsGATtTAP X 9561; 2009; 4270; 13537; 41334; 60180 +GSK3B GSK3B P49841 human Tau iso8 4137 P10636-8 MAPT human T217 449078 sRtPsLPtPPtREPK X X 33134; 51625 +GSK3B GSK3B P49841 human LSD1 23028 O60341 KDM1A human S683 57786402 NLFGHVGsTTAsRGE Amino_oxidase X X +GSK3B GSK3B P49841 human ACF7 23499 Q9UPN3 MACF1 human S7230 18507014 KPSsRAAsPTRsssS X X +GSK3B GSK3B P49841 human FBXL2 25827 Q9UKC9 FBXL2 human T404 15278700 HAYFAPVtPPTAVAG X X +GSK3B GSK3B P49841 human Doublecortin iso2 1641 O43602-2 DCX human S327 451363 StPKSKQsPIStPTs X X +GSK3B GSK3B P49841 human TSC2 24855 P49816 Tsc2 rat S1381 450215 VDLsFQPsQPLsKSS X X +GSK3B GSK3B P49841 human IL22RA1 230828 Q80XZ4 Il22ra1 mouse S410 23115552 YAVCVEDsGKDsTPG X X +GSK3B GSK3B P49841 human EIF6 3692 P56537 EIF6 human S243 3193267 MRDsLIDsLt_____ X +GSK3B GSK3B P49841 human Jun 3725 P05412 JUN human T239 450450 VPEMPGEtPPLsPID Jun X +GSK3B GSK3B P49841 human Tau iso8 4137 P10636-8 MAPT human S195 450221 PPKsGDRsGyssPGs X +GSK3B GSK3B P49841 human Tau iso8 4137 P10636-8 MAPT human S214 447929 GsRsRtPsLPtPPtR X 77348 +GSK3B GSK3B P49841 human SMAD1 4086 Q15797 SMAD1 human T202 9693200 sPGSSSStYPHsPTS X +GSK3B GSK3B P49841 human USF2 7392 Q15853 USF2 human T230 3801550 PkIDGtRtPRDERRR X X +GSK3B GSK3B P49841 human EIF6 3692 P56537 EIF6 human T231 31863506 LNEAQPstIAtsMRD X +GSK3B GSK3B P49841 human IKKG 8517 Q9Y6K9 IKBKG human S31 449036 QDVLGEEsPLGKPAM X X +GSK3B GSK3B P49841 human Tau iso8 4137 P10636-8 MAPT human T50 447931 LkEsPLQtPtEDGsE X +GSK3B GSK3B P49841 human CRMP-5 56896 Q9BPU6 DPYSL5 human T516 478232 tPLADtPtRPVTRHG X +GSK3B GSK3B P49841 human NRF2 18024 Q60795 Nfe2l2 mouse S338 18258501 NDSDsGIsLNTsPSR X X +GSK3B GSK3B P49841 human IL17RA 23765 Q96F46 IL17RA human T780 41452470 MVLTDPHtPYEEEQR X +GSK3B GSK3B P49841 human SMAD4 4089 Q13485 SMAD4 human T273 36694102 TTWtGSRtAPYtPNL X +GSK3B GSK3B P49841 human MAFA 378435 Q8CF90 Mafa mouse S61 1320401 PLStPCSsVPSsPSF X +GSK3B GSK3B P49841 human ULK1 22241 O70405 Ulk1 mouse S913 10428808 KVAELLSsGLQTAID DUF3543 X +GSK3B GSK3B P49841 human HRas 3265 P01112 HRAS human T148 23113995 YIEtsAktRQGVEDA Ras X X +GSK3B GSK3B P49841 human 4E-BP1 1978 Q13541 EIF4EBP1 human T70 447528 rNsPVtktPPRDLPt eIF_4EBP X 9455; 13396 +GSK3B GSK3B P49841 human myocardin 214384 Q8VIM5 Myocd mouse S466 3627506 PPIsPASsDLSAAGS X X +GSK3B GSK3B P49841 human JunB 3726 P17275 JUNB human S251 465702 QTVPEARsRDAtPPV Jun X +GSK3B GSK3B P49841 human Snail2 6591 O43623 SNAI2 human S104 25603909 KDHsGSEsPISDEEE X X +GSK3B GSK3B P49841 human HSP90A 3320 P07900 HSP90AA1 human S726 3180213 LEGDDDtsRMEEVD_ X +GSK3B GSK3B P49841 human CAP1 12331 P40124 Cap1 mouse S309 2525971 PKPQtsPsPKPAtKK X +GSK3B GSK3B P49841 human Aiolos 22806 Q9UKT9 IKZF3 human S378 4696322 VPSERGLsPNNSGHD X +GSK3B GSK3B P49841 human Ets-1 2113 P14921 ETS1 human S269 1873117008 DRLtQsWssQssFNs Ets1_N_flank X +GSK3B GSK3B P49841 human TSC2 24855 P49816 Tsc2 rat T1373 469994 SSEGARPtVDLsFQP X X +GSK3B GSK3B P49841 human CREB iso1 81646 P15337-1 Creb1 rat S129 450092 QKRREILsRRPsYRk pKID X +GSK3B GSK3B P49841 human RAB11FIP5 26056 Q9BXF6 RAB11FIP5 human T276 32674000 GPGAELLtRsPsRss X X +GSK3B GSK3B P49841 human SP1 6667 P08047 SP1 human S732 2535903 PLDsGAGsEGSGtAt X +GSK3B GSK3B P49841 human SMAD4 4089 Q13485 SMAD4 human T269 36694100 HNStTTWtGSRtAPY X +GSK3B GSK3B P49841 human WT1 iso7 7490 P19544-7 WT1 human S63 1871128700 ERLQGRRsRGAsGsE X X +GSK3B GSK3B P49841 human TNKS 8658 O95271 TNKS human S987 471335 AStPSCLsAASsIDN X +GSK3B GSK3B P49841 human HSP90A 3320 P07900 HSP90AA1 human T725 3180216 PLEGDDDtsRMEEVD X +GSK3B GSK3B P49841 human smMLCK 4638 Q15746 MYLK human S1776 468781 GRKsstGsPtsPLNA X +GSK3B GSK3B P49841 human NR1D1 9572 P20393 NR1D1 human S55 471091 CPTYFPPsPTGsLTQ X X 2129 +GSK3B GSK3B P49841 human FBXO4 26272 Q9UKT5 FBXO4 human S12 453026 EPRsGtNsPPPPFSD X X +GSK3B GSK3B P49841 human ACF7 23499 Q9UPN3 MACF1 human S7234 18507013 RAAsPTRsssSAsQs X X +GSK3B GSK3B P49841 human AHR 196 P35869 AHR human S444 1874101920 GkDsATTsTLSKDSL X +GSK3B GSK3B P49841 human Snail2 6591 O43623 SNAI2 human S100 25603907 DTSsKDHsGSEsPIS X X +GSK3B GSK3B P49841 human MLK3 4296 Q16584 MAP3K11 human S789 487506 VsAGPRPsPLPsPQP X X +GSK3B GSK3B P49841 human CRMP-4 25418 Q62952 Dpysl3 rat T514 458798 TTtPKGGtPAGsTRG X +GSK3B GSK3B P49841 human Raptor 57521 Q8N122 RPTOR human S863 453732 LtQsAPAsPtNkGVH X +GSK3B GSK3B P49841 human CRMP-4 25418 Q62952 Dpysl3 rat S518 458799 KGGtPAGsTRGsPTR X +GSK3B GSK3B P49841 human Tau iso8 4137 P10636-8 MAPT human T181 447932 ktPPAPktPPssGEP X X 12885; 66224; 62672 +GSK3B GSK3B P49841 human ULK1 22241 O70405 Ulk1 mouse S405 23070960 HGRTPsPsPTCSSSP X +GSK3B GSK3B P49841 human Myb 17863 P06876 Myb mouse T572 1308922 LTSSVLMtPVSEDED X X +GSK3B GSK3B P49841 human DRP1 10059 O00429 DNM1L human S616 454690 PIPIMPAsPQKGHAV X 3455; 4494; 63940 +GSK3B GSK3B P49841 human PICK1 9463 Q9NRD5 PICK1 human S415 50642302 kGGsWCDs_______ X +GSK3B GSK3B P49841 human CLASP2 23122 O75122 CLASP2 human S533 22349885 QGCsREAsREssRDT X X +GSK3B GSK3B P49841 human ZAP 252832 Q8K3Y6 Zc3hav1 rat S283 483725 DVTsCKDsLEDVsVD X +GSK3B GSK3B P49841 human neurogenin 2 11924 P70447 Neurog2 mouse S234 2255100 SCTLsPAsPGSDVDy X +GSK3B GSK3B P49841 human TBK1 29110 Q9UHD2 TBK1 human S172 447732 EDDEQFVsLyGTEEy Pkinase X 5483; 13498; 14590; 14586; 54382; 70483; 20399 +GSK3B GSK3B P49841 human GRB14 2888 Q14449 GRB14 human S419 24986639 LRLGTHGsPtAsSQS X +GSK3B GSK3B P49841 human RAB11FIP5 26056 Q9BXF6 RAB11FIP5 human S188 4957683 sMKDKPRsPFsKIRD X +GSK3B GSK3B P49841 human CCNE1 898 P24864 CCNE1 human T395 447676 PLPSGLLtPPQsGKK X X +GSK3B GSK3B P49841 human GR 2908 P04150 NR3C1 human S404 5044100 SMRPDVSsPPSSSST X X +GSK3B GSK3B P49841 human MCL1 4170 Q07820 MCL1 human T163 455375 tDGsLPstPPPAEEE X 4579; 14765 +GSK3B GSK3B P49841 human GYS1 100008660 P13834 GYS1 rabbit S649 448239 VPPsPSLsRHSsPHQ Glycogen_syn X +GSK3B GSK3B P49841 human 4E-BP1 1978 Q13541 EIF4EBP1 human T37 447497 PPGDysttPGGtLFs eIF_4EBP X X 2855; 9459; 2846; 5123; 3929; 7547; 45613; 39788 +GSK3B GSK3B P49841 human HSF1 3297 Q00613 HSF1 human S303 449045 RVkEEPPsPPQsPRV Vert_HS_TF X +GSK3B GSK3B P49841 human Tau iso8 4137 P10636-8 MAPT human T175 449077 AtRIPAktPPAPktP X +GSK3B GSK3B P49841 human TRAF6 7189 Q9Y4K3 TRAF6 human T266 1867864101 ARHLQENtQSHMRML X +GSK3B GSK3B P49841 human Bcl-2L12 83596 Q9HB09 BCL2L12 human S156 9258022 SESPRPCsLPIRPCY X X +GSK3B GSK3B P49841 human TUSC5 237858 Q8C838 Trarg1 mouse S76 7829266 PsLsGsPsRVssRRA X +GSK3B GSK3B P49841 human MAP1B 17755 P14873 Map1b mouse S1260 454136 sLsPsPPsPIEKtPL X X +GSK3B GSK3B P49841 human OSBP2 23762 Q969R2 OSBP2 human S768 15721697 HssPssPsSDGKQKT Oxysterol_BP X +GSK3B GSK3B P49841 human HRas 3265 P01112 HRAS human S183 25324401 ESGPGCMsCKCVLS_ X +GSK3B GSK3B P49841 human ACF7 23499 Q9UPN3 MACF1 human S7326 18507011 RAGsRAssRRGsDAs X X +GSK3B GSK3B P49841 human NDEL1 83431 Q9ERR1 Ndel1 mouse S332 1869686802 PPPGLGSsRPSsAPG X +GSK3B GSK3B P49841 human CRMP-2 25416 P47942 Dpysl2 rat S518 448081 KTVtPASsAKTsPAK X +GSK3B GSK3B P49841 human ZNF322A 79692 Q6U7Q0 ZNF322 human S391 31086030 SEKGLELsPPHAsEA X +GSK3B GSK3B P49841 human Snail1 6615 O95863 SNAI1 human S96 455883 TsLsDEDsGkGsQPP X X +GSK3B GSK3B P49841 human Myc 4609 P01106 MYC human S77 448586 LLPtPPLsPsRRsGL Myc_N X 13748 +GSK3B GSK3B P49841 human ADD2 119 P35612 ADD2 human S613 3147399 AKEAEtKsPLVsPsK X +GSK3B GSK3B P49841 human GYS1 100008660 P13834 GYS1 rabbit S641 448237 YRYPRPAsVPPsPSL Glycogen_syn X +GSK3B GSK3B P49841 human ACBD5 iso2 91452 Q5T8D3-2 ACBD5 human S269 34501844 DsEVYCDsMEQFGQE X X +GSK3B GSK3B P49841 human SOX4 20677 Q06831 Sox4 mouse S316 41454646 GRSSAAssPAASRSP X +GSK3B GSK3B P49841 human Tip60 10524 Q92993 KAT5 human S90 448827 LPGsRPGsPEREVPA X X +GSK3B GSK3B P49841 human RXRA 6256 P19793 RXRA human S66 333674900 NGMGPPFsVISSPMG Nuc_recep-AF1 X +GSK3B GSK3B P49841 human CTNNB1 1499 P35222 CTNNB1 human S33 447487 QQQsyLDsGIHsGAT X X 9561; 2009; 4270; 13537; 41334; 60180 +GSK3B GSK3B P49841 human APC 324 P25054 APC human S1503 999607 TPDGFsCsssLsALs APC_r X +GSK3B GSK3B P49841 human ZAP 252832 Q8K3Y6 Zc3hav1 rat S266 4776621 EFLsPVVsPLGsGPP X X +GSK3B GSK3B P49841 human MITF iso9 4286 O75030-9 MITF human S397 11126131 DPLLSSVsPGAsKTS DUF3371 X +GSK3B GSK3B P49841 human MARK2 60328 O08679 Mark2 rat S212 450068 KLDtFCGsPPYAAPE Pkinase X +GSK3B GSK3B P49841 human AHR 196 P35869 AHR human S436 1874101916 LRTKNGTsGkDsATT X +GSK3B GSK3B P49841 human PU.1 6688 P17947 SPI1 human S140 451055 EEEGERQsPPLEVsD X X +GSK3B GSK3B P49841 human Wee1 7465 P30291 WEE1 human S211 25316773 SSVkLRGssLFMDtE X +GSK3B GSK3B P49841 human PHLPP 23239 O60346 PHLPP1 human S1359 22769300 VPRPHVQsVLLtPQD PP2C X X +GSK3B GSK3B P49841 human Tau iso8 4137 P10636-8 MAPT human T212 447934 tPGsRsRtPsLPtPP X X +GSK3B GSK3B P49841 human IRF1 16362 P15314 Irf1 mouse S185 1380568701 RDItPALsPCVVSSS X +GSK3B GSK3B P49841 human EB1 22919 Q15691 MAPRE1 human S155 476322 kPkkPLtssSAAPQR X +GSK3B GSK3B P49841 human SSH2 237860 Q5SW75 Ssh2 mouse S32 22775200 sGEEECRsQPRsIsE X X +GSK3B GSK3B P49841 human myocardin 214384 Q8VIM5 Myocd mouse S636 3627511 PQCsPQHsPLGGLKS X X +GSK3B GSK3B P49841 human ataxin-3 4287 P54252 ATXN3 human S256 479405 LRRAIQLsMQGsSRN UIM X +GSK3B GSK3B P49841 human CABYR 26256 O75952 CABYR human S155 11454100 KTTtPPSsPPPTAVS X +GSK3B GSK3B P49841 human myocardin 214384 Q8VIM5 Myocd mouse S632 3627509 TFLsPQCsPQHsPLG X X +GSK3B GSK3B P49841 human OSBP2 23762 Q969R2 OSBP2 human S763 31727226 CSKVMHssPssPsSD Oxysterol_BP X +GSK3B GSK3B P49841 human NFkB-p100 4791 Q00653 NFKB2 human S222 3193889 QPIHDSKsPGASNLk X X +GSK3B GSK3B P49841 human GFI1 2672 Q99684 GFI1 human S98 1868711303 RPPsPSAsPASEKSM X X +GSK3B GSK3B P49841 human EZH2 2146 Q15910 EZH2 human S363 466986 GRLPNNssRPstPtI X X +GSK3B GSK3B P49841 human SNCAIP 9627 Q9Y6H5 SNCAIP human S556 469990 AQKSEGKsLPssPss SNCAIP_SNCA_bd X X +GSK3B GSK3B P49841 human AHR 196 P35869 AHR human S689 1874101922 SQEFPYKsEMDsMPY X +GSK3B GSK3B P49841 human IRF1 3659 P10914 IRF1 human S184 1380568701 QALtPALsPCAVSST X +GSK3B GSK3B P49841 human MEF2D 81518 O89038 Mef2d rat T145 10359101 PNFAMPVtVPVsNQS HJURP_C X X +GSK3B GSK3B P49841 human NFkB-p100 4791 Q00653 NFKB2 human S707 20804978 EPLCPLPsPPTsDsD X X +GSK3B GSK3B P49841 human Snail1 6615 O95863 SNAI1 human S115 6097707 PAPssFSsTSVsSLE X X +GSK3B GSK3B P49841 human RAPH1 65059 Q70E73 RAPH1 human S1066 23137493 DsVVEFPsPPsDsDF X +GSK3B GSK3B P49841 human CLASP2 23122 O75122 CLASP2 human S503 22349881 IPRsQGCsREAsPsR X +GSK3B GSK3B P49841 human CTNNB1 1499 P35222 CTNNB1 human T41 447583 GIHsGATtTAPsLsG X X 9561; 9565; 4270; 13537; 41334; 60180 +GSK3B GSK3B P49841 human DRP1 10059 O00429 DNM1L human S693 27276100 LVGQLYKsSLLDDLL GED X X +GSK3B GSK3B P49841 human VHL 7428 P40337 VHL human S68 469116 PVLRSVNsREPsQVI VHL X +GSK3B GSK3B P49841 human MAFA 378435 Q8CF90 Mafa mouse T57 456028 LSStPLStPCSsVPS X +GSK3B GSK3B P49841 human MNX1 15285 Q9QZW9 Mnx1 mouse S80 3191344 RLRAEsPsPPRLLAA X X +GSK3B GSK3B P49841 human MAP2 iso3 25595 P15146-3 Map2 rat T262 450182 RTPGtPGtPSYPRTP X +GSK3B GSK3B P49841 human Src 6714 P12931 SRC human S493 1871762502 CPPECPEsLHDLMCQ PK_Tyr_Ser-Thr X +GSK3B GSK3B P49841 human CCND2 894 P30279 CCND2 human T280 469202 DELDQAstPtDVRDI Cyclin_C X X +GSK3B GSK3B P49841 human RICTOR 253260 Q6R327 RICTOR human S1235 458282 GIssMSssPSRETVG X +GSK3B GSK3B P49841 human Snail2 6591 O43623 SNAI2 human S92 25603910 RVsPPPPsDTSsKDH X X +GSK3B GSK3B P49841 human VDAC1 7416 P21796 VDAC1 human S13 479874 TYADLGksARDVFtk Porin_3 X +GSK3B GSK3B P49841 human SOX11 20666 Q7M6Y2 Sox11 mouse S289 50800237 PPAPPALsPASSRCV X +GSK3B GSK3B P49841 human PPAR-alpha 19013 P23204 Ppara mouse S73 59026900 SVITDTLsPASSPSS X +GSK3B GSK3B P49841 human Desmoplakin 1832 P15924 DSP human S2849 451165 RsGsRRGsFDAtGNs X +GSK3B GSK3B P49841 human FOXM1 iso2 2305 Q08050-2 FOXM1 human S474 22648002 PPLEEWPsPAPSFkE X +GSK3B GSK3B P49841 human GLE1 2733 Q53GS7 GLE1 human S93 31084897 PKsPDAssAFsPAsP X +GSK3B GSK3B P49841 human NFH 24587 P16884 Nefh rat S493 455548 GEEAATTsPPAEEAA X +GSK3B GSK3B P49841 human PPP1R2 5504 P41236 PPP1R2 human T73 449051 MKIDEPstPyHSMMG IPP-2 X X +GSK3B GSK3B P49841 human PHLPP 23239 O60346 PHLPP1 human S1381 22769301 KGLWDsLsVEEAVEA PP2C X +GSK3B GSK3B P49841 human 4E-BP1 1978 Q13541 EIF4EBP1 human T46 447496 GGtLFsttPGGtRII eIF_4EBP X X 2855; 9459; 2846; 4923; 5123; 3929; 7547; 45613; 39788 +GSK3B GSK3B P49841 human CTNND1 12388 P30999 Ctnnd1 mouse S252 450456 MEGyRAPsRQDVyGP X 8477 +GSK3B GSK3B P49841 human AHR 196 P35869 AHR human T731 1874101932 FEPsPYPtTSSLEDF X +GSK3B GSK3B P49841 human SPAG5 10615 Q96R06 SPAG5 human T937 460416 ADEEPEStPVPLLGs X X +GSK3B GSK3B P49841 human MEF2D 81518 O89038 Mef2d rat S149 10359103 MPVtVPVsNQSsMQF HJURP_C X X +GSK3B GSK3B P49841 human EIF6 3692 P56537 EIF6 human S239 3193264 IAtsMRDsLIDsLt_ X +GSK3B GSK3B P49841 human Src 6714 P12931 SRC human Y419 448234 RLIEDNEytARQGAk PK_Tyr_Ser-Thr X X 2101; 6943; 59548; 70926; 78740; 94361; 17320 +GSK3B GSK3B P49841 human C/EBP-delta 1052 P49716 CEBPD human S167 28852500 SPEPPRSsPRQtPAP X X +GSK3B GSK3B P49841 human NIFK 84365 Q9BYG3 NIFK human T234 449332 tVDsQGPtPVCtPtF hNIFK_binding X +GSK3B GSK3B P49841 human CCNE1 898 P24864 CCNE1 human T77 454411 DPCsLIPtPDKEDDD X 4136 +GSK3B GSK3B P49841 human Ets-1 2113 P14921 ETS1 human T265 31087093 yDsCDRLtQsWssQs Ets1_N_flank X +GSK3B GSK3B P49841 human Myc 17869 P01108 Myc mouse T73 448496 KKFELLPtPPLsPsR Myc_N X 46650 +GSK3B GSK3B P49841 human NRF2 4780 Q16236 NFE2L2 human S344 18258505 AEFNDSDsGIsLNTs X X +GSK3B GSK3B P49841 human GYS1 2997 P13807 GYS1 human S645 448238 RPAsVPPsPsLsRHs Glycogen_syn X +GSK3B GSK3B P49841 human NFE2L1 4779 Q14494 NFE2L1 human S379 27971902 SQDFLLFsPEVESLP X X +GSK3B GSK3B P49841 human GLE1 2733 Q53GS7 GLE1 human S92 50831365 VPKsPDAssAFsPAs X +GSK3B GSK3B P49841 human EZH2 2146 Q15910 EZH2 human T367 466987 NNssRPstPtINVLE X X +GSK3B GSK3B P49841 human Tau iso8 4137 P10636-8 MAPT human T205 447933 ssPGsPGtPGsRsRt X X 25377; 43964; 53001; 49561; 20060; 33032; 30505; 20739; 98160 +GSK3B GSK3B P49841 human TUSC5 237858 Q8C838 Trarg1 mouse S80 3842521 GsPsRVssRRAssVI X +GSK3B GSK3B P49841 human FBXL20 84961 Q96IG2 FBXL20 human S421 467840 APVtPPPsVGGsRQR X X +GSK3B GSK3B P49841 human MARK2 2011 Q7KZI7 MARK2 human S212 450068 KLDtFCGsPPYAAPE Pkinase X +GSK3B GSK3B P49841 human NFAT1 18019 Q60591 Nfatc2 mouse S219 447846 AHYsPRtsPIMsPRT X +GSK3B GSK3B P49841 human KLF5 688 Q13887 KLF5 human S303 14652801 QATYFPPsPPSSEPG X X +GSK3B GSK3B P49841 human GRB14 2888 Q14449 GRB14 human S366 29576856 GCSsQSIsPMRsIsE X X +GSK3B GSK3B P49841 human CRMP-4 1809 Q14195 DPYSL3 human T509 454328 PVFDLtttPkGGtPA X X +GSK3B GSK3B P49841 human SERT 6532 P31645 SLC6A4 human S48 1869992415 GQISNGysAVPSPGA 5HT_transport_N X +GSK3B GSK3B P49841 human IRF1 3659 P10914 IRF1 human T180 1380568700 LEVEQALtPALsPCA X +GSK3B GSK3B P49841 human Tau iso8 4137 P10636-8 MAPT human S422 449083 GsIDMVDsPQLAtLA X X +GSK3B GSK3B P49841 human RXRA 6256 P19793 RXRA human S78 333674902 PMGPHSMsVPTtPTL Nuc_recep-AF1 X +GSK3B GSK3B P49841 human PD-L1 29126 Q9NZQ7 CD274 human T180 63237406 QVLSGkTtTTNsKRE C2-set_2 X X +GSK3B GSK3B P49841 human USF2 7392 Q15853 USF2 human S155 36392500 NPFSNGGsPAAEAVS X X +GSK3B GSK3B P49841 human Tau iso8 4137 P10636-8 MAPT human S235 449080 VVRtPPKsPssAKsR X 20473 +GSK3B GSK3B P49841 human GLE1 2733 Q53GS7 GLE1 human S88 12667856 QPSFVPKsPDAssAF X +GSK3B GSK3B P49841 human ENDOG 2021 Q14249 ENDOG human T128 1871762501 VHAYHRAtNADYRGS Endonuclease_NS X X +GSK3B GSK3B P49841 human IRF3 3661 Q14653 IRF3 human S173 6370303 PCPQPLRsPsLDNPt X X +GSK3B GSK3B P49841 human p21Cip1 1026 P38936 CDKN1A human T57 451222 NFDFVtEtPLEGDFA CDI X +GSK3B GSK3B P49841 human SSH2 237860 Q5SW75 Ssh2 mouse S21 17544228 TTSsPCAsEADsGEE X X +GSK3B GSK3B P49841 human CRMP-4 1809 Q14195 DPYSL3 human S518 458799 kGGtPAGsArGsPtR X X +GSK3B GSK3B P49841 human AHR 196 P35869 AHR human S693 1874101924 PYKsEMDsMPYtQNF X +GSK3B GSK3B P49841 human gephyrin 268566 Q8BUV3 Gphn mouse S270 2020113 LsttPsEsPRAQATs X +GSK3B GSK3B P49841 human RBM38 56190 Q62176 Rbm38 mouse S193 29606707 DQYPYAAsPAAATSF X +GSK3B GSK3B P49841 human TRAF4AF1 90417 Q9Y448 KNSTRN human T294 1876350206 VRFLEQQtLCNNQVN X X +GSK3B GSK3B P49841 human Raptor 57521 Q8N122 RPTOR human S722 2314601 PrLrsVssyGNIRAV X +GSK3B GSK3B P49841 human MLK3 4296 Q16584 MAP3K11 human S793 448613 PRPsPLPsPQPAPRR X X +GSK3B GSK3B P49841 human IKKG 8517 Q9Y6K9 IKBKG human S17 50564412 LCEMVQPsGGPAADQ X X +GSK3B GSK3B P49841 human HDAC4 9759 P56524 HDAC4 human S298 1322400 ACSSAPGsGPSsPNN X X +GSK3B GSK3B P49841 human Tau iso8 4137 P10636-8 MAPT human S210 487450 PGtPGsRsRtPsLPt X +GSK3B GSK3B P49841 human AREL1 iso2 9870 O15033-2 AREL1 human T783 56589716 IAAPTHStLPTAHT_ HECT X X +GSK3B GSK3B P49841 human CRMP-2 25416 P47942 Dpysl2 rat T509 448083 PVCEVSVtPKTVtPA X X +GSK3B GSK3B P49841 human CAP1 10487 Q01518 CAP1 human S308 485063 sAPKPQtsPsPkRAt X +GSK3B GSK3B P49841 human Securin 9232 O95997 PTTG1 human S183 20764101 SNLLQSPssILSTLD Securin X X +GSK3B GSK3B P49841 human C/EBP-beta 24253 P21272 Cebpb rat S185 455886 LSTsSSSsPPGtPSP X X +GSK3B GSK3B P49841 human CTNND1 12388 P30999 Ctnnd1 mouse T310 450457 GtARRtGtPsDPRRR X +GSK3B GSK3B P49841 human BORA 79866 Q6PGQ7 BORA human S274 9318308 TSPsPISsPTFsPIE X X +GSK3B GSK3B P49841 human MYBPC3 4607 Q14896 MYBPC3 human S133 27463600 ELGESAPsPKGSSSA X +GSK3B GSK3B P49841 human TRIM72 493829 Q6ZMU5 TRIM72 human S255 27461213 LQKILAEsPPPARLD X X +GSK3B GSK3B P49841 human SIGIRR 59307 Q6IA17 SIGIRR human T372 1873759800 EPSAPPHtSGVSLGE X +GSK3B GSK3B P49841 human ACF7 23499 Q9UPN3 MACF1 human S7310 18507009 ADPKKSAsRPGsRAG X X +GSK3B GSK3B P49841 human PPIF 10105 P30405 PPIF human S191 27460203 IEsFGsksGRTSKKI Pro_isomerase X +GSK3B GSK3B P49841 human EGLN2 112398 Q96KS0 EGLN2 human T405 50777944 VPVsQPPtPT_____ X +GSK3B GSK3B P49841 human NACA 4666 E9PAV3 NACA human T2022 451197 NIQENtQtPtVQEEs X X +GSK3B GSK3B P49841 human Snail1 6615 O95863 SNAI1 human S111 6097705 sPPsPAPssFSsTSV X X +GSK3B GSK3B P49841 human Telethonin 8557 O15273 TCAP human S161 3893741 RsLsRSMsQEAQRG_ Telethonin X +MAPKAPK3 MAPKAPK3 Q16644 human TAB3 257397 Q8N5C8 TAB3 human S506 1295507 HKYQRsSsSGSDDyA X +MAPKAPK3 MAPKAPK3 Q16644 human beclin 1 8678 Q14457 BECN1 human S90 472001 IPPARMMstEsANsF X 29362; 86455 +MAPKAPK3 MAPKAPK3 Q16644 human HSP27 3315 P04792 HSPB1 human S82 448403 RALsRQLssGVsEIr X 2406; 2401; 9709; 11892; 64293 +Ikbkb IKKB O88351 mouse IkB-alpha 18035 Q9Z1E3 Nfkbia mouse S32 448203 LVDDRHDsGLDsMKD X X 5210; 2859; 9246; 5209 +Ikbkb IKKB O88351 mouse NFkB-p105 18033 P25799 Nfkb1 mouse S935 447771 CDSGVETsFRKLsFt X X 4806; 4808; 41317 +Ikbkb IKKB O88351 mouse IKKB 16150 O88351 Ikbkb mouse S181 447489 DQGsLCTsFVGTLQy Pkinase X 2697; 2694; 14938; 92255; 36516; 36214 +Ikbkb IKKB O88351 mouse IKKB 16150 O88351 Ikbkb mouse S701 17934904 ACDsLPEsDKKsEEL X +Ikbkb IKKB O88351 mouse XBP1 22433 O35426 Xbp1 mouse S148 63075900 PEVEAKGsGVRLVAG X +Ikbkb IKKB O88351 mouse IKKB 16150 O88351 Ikbkb mouse S705 17934902 LPEsDKKsEELVAEA X +Ikbkb IKKB O88351 mouse SNAP23 20619 O09044 Snap23 mouse S95 455262 NRTkNFEsGKNYkAt SNAP-25 X +Ikbkb IKKB O88351 mouse IKKB 16150 O88351 Ikbkb mouse S679 5735027 sPDsMNVsRLsHPGQ X +Ikbkb IKKB O88351 mouse IKKB 16150 O88351 Ikbkb mouse S689 3676802 sHPGQLMsQPsSACD X +Ikbkb IKKB O88351 mouse IKKB 16150 O88351 Ikbkb mouse S697 17934903 QPsSACDsLPEsDKK X +Ikbkb IKKB O88351 mouse IkB-alpha 18035 Q9Z1E3 Nfkbia mouse S36 448204 RHDsGLDsMKDEEYE X X 5210; 9246 +Ikbkb IKKB O88351 mouse Cot 26410 Q07174 Map3k8 mouse T290 455276 LPKDLRGtEIYMSPE Pkinase X +Ikbkb IKKB O88351 mouse IKKB 16150 O88351 Ikbkb mouse S682 17934901 sMNVsRLsHPGQLMs X +Ikbkb IKKB O88351 mouse XBP1 22433 O35426 Xbp1 mouse T48 21688103 AGSEASGtPQARKRQ X +Ikbkb IKKB O88351 mouse SNAP23 20619 O09044 Snap23 mouse S120 455263 NVVskQPsRITNGQP SNAP-25 X +Ikbkb IKKB O88351 mouse NFkB-p65 19697 Q04207 Rela mouse S534 447800 sGDEDFssIADMDFS X X 4887; 3036; 3031; 4886; 3033; 4025; 5733; 13346; 76778; 31553; 80477; 73992; 87672; 83962 +Ikbkb IKKB O88351 mouse IKKB 16150 O88351 Ikbkb mouse S692 5735033 GQLMsQPsSACDsLP X +Ikbkb IKKB O88351 mouse BAD 12015 Q61337 Bad mouse S26 27530804 KsDPGIRsLGSDAGG X X +SBK1 SBK Q52WX2 human Nur77 15370 P12813 Nr4a1 mouse S344 451513 KEVVRTDsLKGRRGR X X +BMX Etk P51813 human FAK 5747 Q05397 PTK2 human Y925 447966 DRsNDkVyENVtGLV Focal_AT X 3284 +BMX Etk P51813 human FGFR1 2260 P11362 FGFR1 human Y653 447918 RDIHHIDyykKTTNG PK_Tyr_Ser-Thr X 3471; 3476; 52928 +BMX Etk P51813 human Ack 10188 Q07912 TNK2 human Y860 448884 KVsstHyyLLPERPs X +BMX Etk P51813 human BAK1 578 Q16611 BAK1 human Y108 15794303 QPTAENAyEyFTkIA Bcl-2 X X +BMX Etk P51813 human FAK 5747 Q05397 PTK2 human Y577 447890 yMEDstyyKAsKGKL PK_Tyr_Ser-Thr X X 3281 +BMX Etk P51813 human FAK 5747 Q05397 PTK2 human Y1007 2867002 kMKLAQQyVMTSLQQ Focal_AT X +BMX Etk P51813 human PAK1 5058 Q13153 PAK1 human Y153 463955 tDksAEDyNssNALN X +BMX Etk P51813 human FAK 5747 Q05397 PTK2 human Y898 485796 LSsPADSyNEGVKLQ X +BMX Etk P51813 human Ack 10188 Q07912 TNK2 human Y859 448883 KKVsstHyyLLPERP X +BMX Etk P51813 human RUFY1 80230 Q96T51 RUFY1 human Y400 451278 RQGLDEMysDVWKQL X +BMX Etk P51813 human FAK 5747 Q05397 PTK2 human Y742 6153381 HMVQTNHyQVSGYPG X +BMX Etk P51813 human FGFR1 2260 P11362 FGFR1 human Y654 447919 DIHHIDyykKTTNGR PK_Tyr_Ser-Thr X 3471; 3476; 52928 +BMX Etk P51813 human FAK 5747 Q05397 PTK2 human Y861 447965 PIGNQHIyQPVGKPD X +BMX Etk P51813 human P130Cas 9564 P56945 BCAR1 human Y12 4251353 NVLAKALyDNVAEsP SH3_1 X +BMX Etk P51813 human FAK 5747 Q05397 PTK2 human Y441 462051 GDVHQGIyMsPENPA PK_Tyr_Ser-Thr X +BMX Etk P51813 human FAK 5747 Q05397 PTK2 human Y194 18122800 ALEKKSNyEVLEkDV FERM_M X +BMX Etk P51813 human RUFY1 80230 Q96T51 RUFY1 human Y389 451277 TKVELETykQTRQGL X +BMX Etk P51813 human FAK 5747 Q05397 PTK2 human Y576 447889 RyMEDstyyKAsKGK PK_Tyr_Ser-Thr X 3281 +BMX Etk P51813 human Met 4233 P08581 MET human Y1235 448471 DMyDkEyysVHNktG PK_Tyr_Ser-Thr X 4091; 3129; 3126; 3077; 12468; 4033; 98954 +PLK2 PLK2 Q9NYY3 human CRYAB 1410 P02511 CRYAB human S19 447728 RPFFPFHsPsrLFDQ Crystallin X +PLK2 PLK2 Q9NYY3 human 14-3-3 epsilon 7531 P62258 YWHAE human T208 14569209 DAIAELDtLsEEsyk 14-3-3 X +PLK2 PLK2 Q9NYY3 human CALU 813 O43852 CALU human S44 4274908 kVHNDAQsFDyDHDA X +PLK2 PLK2 Q9NYY3 human CENPJ 55835 Q9HC77 CENPJ human S595 14918201 IsFSSNSsFVLKILE X X +PLK2 PLK2 Q9NYY3 human FBXW7 55294 Q969H0 FBXW7 human S349 25126711 IKPGFIHsPWKSAYI X +PLK2 PLK2 Q9NYY3 human CALU 813 O43852 CALU human T60 25688700 LGAEEAktFDQLtPE X +PLK2 PLK2 Q9NYY3 human SNCB 6620 Q16143 SNCB human S118 448525 LMEPEGEsYEDPPQE Synuclein X +PLK2 PLK2 Q9NYY3 human PLK1 5347 P53350 PLK1 human S137 448138 LELCRRRsLLELHkR Pkinase X X +PLK2 PLK2 Q9NYY3 human TACE 11491 Q9Z0F8 Adam17 mouse S794 449040 NsSTAAKsFEDLTDH X +PLK2 PLK2 Q9NYY3 human SNCA 6622 P37840 SNCA human S129 448278 NEAyEMPsEEGyQDy Synuclein X X 23706; 87281 +PLK2 PLK2 Q9NYY3 human CENPJ 55835 Q9HC77 CENPJ human S589 14918202 EQAADEIsFSSNSsF X X +PLK2 PLK2 Q9NYY3 human p73 7161 O15350 TP73 human S48 52434701 VVGGTDssMDVFHLE X X +PLK2 PLK2 Q9NYY3 human NRF2 83619 O54968 Nfe2l2 rat S40 450082 SREVFDFsQRQKDYE X X +PLK2 PLK2 Q9NYY3 human CALU 813 O43852 CALU human T196 25688702 KDIVVQEtMEDIDKN EF-hand_5 X +PLK2 PLK2 Q9NYY3 human NPM1 4869 P06748 NPM1 human S4 452023 ____MEDsMDMDMsP X X 3520 +PLK2 PLK2 Q9NYY3 human FBXW7 55294 Q969H0 FBXW7 human S176 25126709 KRKLDHGsEVRSFSL X X +PLK2 PLK2 Q9NYY3 human FBXW7 55294 Q969H0 FBXW7 human S25 25126710 sLRGNPSssQVDEEQ X +ARAF ARAF P10398 human MEK1 5604 Q02750 MAP2K1 human S222 448513 LIDsMANsFVGtRSY Pkinase X X 2338; 9121; 3958; 9154; 16211; 86128; 16780; 75262 +ARAF ARAF P10398 human MEK1 5604 Q02750 MAP2K1 human S218 448514 VsGQLIDsMANsFVG Pkinase X X 9121; 3958; 9154; 86128 +ARAF ARAF P10398 human BAD 572 Q92934 BAD human S99 447862 PFrGrsRsAPPNLWA Bcl-2_BAD X 9295; 5286; 4366 +ARAF ARAF P10398 human BAD 572 Q92934 BAD human S75 447860 EIRsRHssyPAGtED Bcl-2_BAD X 9291; 5284; 9296; 5193; 11865; 94223 +ARAF ARAF P10398 human NHERF-2 9351 Q15599 NHERF2 human S303 9765067 QEsGLHLsPtAAEAK EBP50_C X +ARAF ARAF P10398 human BAD 572 Q92934 BAD human S118 447863 GRELRRMsDEFVDsF Bcl-2_BAD X 9297 +Mapk1 ERK2 P63085 mouse IRS1 16367 P35569 Irs1 mouse S612 447562 DDGyMPMsPGVAPVP X 3193; 2386; 3203 +Mapk1 ERK2 P63085 mouse TNRC15 227331 Q6Y7W8 Gigyf2 mouse S30 483131 sItsPPLsPALPKYK X +Mapk1 ERK2 P63085 mouse GATA1 14460 P17679 Gata1 mouse S26 451232 VDSALVSsPSDSTGF X +Mapk1 ERK2 P63085 mouse FOXO1A 56458 Q9R1E0 Foxo1 mouse S475 478372 PPHNDIMsPVDPGVA FOXO_KIX_bdg X X +Mapk1 ERK2 P63085 mouse hnRNP H1 59013 O35737 Hnrnph1 mouse S104 455395 LKHtGPNsPDtANDG X +Mapk1 ERK2 P63085 mouse SNX2 67804 Q9CWK8 Snx2 mouse T104 4774054 sPAVtPVtPttLIAP X +Mapk1 ERK2 P63085 mouse CEP170 545389 Q6A065 Cep170 mouse T562 21686704 EERKPLStPGFHNsE X +Mapk1 ERK2 P63085 mouse FOXO1A 56458 Q9R1E0 Foxo1 mouse S326 448076 stISGRLsPIMtEQD X +Mapk1 ERK2 P63085 mouse GJA1 24392 P08050 Gja1 rat S282 448854 TAPLsPMsPPGYkLV X +Mapk1 ERK2 P63085 mouse FAM65A 75687 Q68FE6 Ripor1 mouse T351 467861 YsQsPPDtPSLREQA PL48 X +Mapk1 ERK2 P63085 mouse BIM 12125 O54918 Bcl2l11 mouse S55 454235 GDRCPHGsPQGPLAP X 4550 +Mapk1 ERK2 P63085 mouse GJA1 14609 P23242 Gja1 mouse S282 448854 tAPLsPMsPPGykLV X +Mapk1 ERK2 P63085 mouse DENND4C 329877 A6H8H2 Dennd4c mouse S1221 3202029 DSEDKLFsPVISRNL X +Mapk1 ERK2 P63085 mouse Spinophilin 217124 Q6R891 Ppp1r9b mouse S205 455382 KLDADAVsPTVSQLs X +Mapk1 ERK2 P63085 mouse PHLDB1 102693 Q6PDH0 Phldb1 mouse S463 7103243 MRELPPLsPsLsRRA X +Mapk1 ERK2 P63085 mouse PHF2 18676 Q9WTU0 Phf2 mouse S651 3175945 KALRPPssPGVFGAL X +Mapk1 ERK2 P63085 mouse NIPA 232679 Q80YV2 Zc3hc1 mouse S353 449745 PIVsRtRsWEsssPV X +Mapk1 ERK2 P63085 mouse MAP1A 17754 Q9QYR6 Map1a mouse T1806 471459 PtRNEPttPSWLAEI X +Mapk1 ERK2 P63085 mouse ERK2 26413 P63085 Mapk1 mouse Y185 447594 HtGFLtEyVAtRWYR Pkinase X 9106; 4370; 4374; 9101; 4375; 4376; 4377; 3510; 5726; 88569; 13214; 13148; 70235; 9488; 89967; 8544; 14196; 14227; 14095; 14474; 75165; 98168; 33370; 54240; 15892; 45899; 55088; 9524; 69217; 48735 +Mapk1 ERK2 P63085 mouse NG2 81651 Q00657 Cspg4 rat T2314 483998 ELLQFCRtPNPALRN X +Mapk1 ERK2 P63085 mouse FRA2 14284 P47930 Fosl2 mouse T322 14573760 SDSLNsPtLLAL___ X +Mapk1 ERK2 P63085 mouse Kv7.2 3785 O43526 KCNQ2 human S476 481668 ADQSLEDsPSKVPKS KCNQ_channel X X +Mapk1 ERK2 P63085 mouse KSR 16706 Q61097 Ksr1 mouse T274 449299 AKLKPPRtPPPPsRK X X +Mapk1 ERK2 P63085 mouse SSBP3 72475 Q9D032 Ssbp3 mouse T360 469908 GIsNPPGtPRDDGEL SSDP X +Mapk1 ERK2 P63085 mouse Hic-5 21804 Q62219 Tgfb1i1 mouse S141 472323 SSPTVPPsPFPAPSK X +Mapk1 ERK2 P63085 mouse TNKS1BP1 228140 P58871 Tnks1bp1 mouse T131 3827252 KEDLPPLtPPARCAA X +Mapk1 ERK2 P63085 mouse ETV1 14009 P41164 Etv1 mouse S146 3059603 tPSStPVsPLHHASP ETS_PEA3_N X +Mapk1 ERK2 P63085 mouse DYNC1I2 13427 O88487 Dync1i2 mouse S81 449148 PIVPPPMsPssKsVs X +Mapk1 ERK2 P63085 mouse GATA6 14465 Q61169 Gata6 mouse S264 2833503 ASARFPYsPSPPMAN GATA-N X +Mapk1 ERK2 P63085 mouse AHNAK2 iso2 100041194 Q3URZ6 Ahnak2 mouse T510 15417563 IPASTIQtPSYGFSL X +Mapk1 ERK2 P63085 mouse NG2 81651 Q00657 Cspg4 rat T2265 9641600 KHDVQVLtAKPRNGL X +Mapk1 ERK2 P63085 mouse AHNAK 66395 E9Q616 Ahnak mouse S4879 3148491 DVEFDIKsPKFKAEA X +Mapk1 ERK2 P63085 mouse BAT2 53761 Q7TSC1 Prrc2a mouse S1002 467535 tPPGGNLsPAPRLRR X +Mapk1 ERK2 P63085 mouse 53BP2 209456 Q8CG79 Trp53bp2 mouse T585 15401906 AAAVRPFtPQPSKDT X +Mapk1 ERK2 P63085 mouse FRA2 14284 P47930 Fosl2 mouse S200 452624 ISPEERRsPPtsGLQ X +Mapk1 ERK2 P63085 mouse SAFB2 224902 Q80YR5 Safb2 mouse S387 454341 RAPtAALsPEPQDsK X +Mapk1 ERK2 P63085 mouse Nidogen-1 18073 P10493 Nid1 mouse S331 21686714 HNVPRILsPGYEATE X +Mapk1 ERK2 P63085 mouse PDXDC1 94184 Q99K01 Pdxdc1 mouse T691 485769 tGVtPPPtPLGtRSK X +Mapk1 ERK2 P63085 mouse TNKS1BP1 228140 P58871 Tnks1bp1 mouse T1025 3211752 GGLLsPstPHsRDGA X +Mapk1 ERK2 P63085 mouse FOXO1A 56458 Q9R1E0 Foxo1 mouse S429 478370 TYGQSSMsPLPQMPM FOXO_KIX_bdg X X +Mapk1 ERK2 P63085 mouse AEBP1 11568 Q640N1 Aebp1 mouse T1003 455321 VDPSRPMtPQQRRMQ X +Mapk1 ERK2 P63085 mouse MAST2 17776 Q60592 Mast2 mouse S1337 4727576 KsAEPPRsPLLKRVQ X +Mapk1 ERK2 P63085 mouse ER-beta 13983 O08537 Esr2 mouse S87 447915 WPTSGHLsPLATHCQ ERbeta_N X +Mapk1 ERK2 P63085 mouse H3 360198 P68433 H3c1 mouse S10 455676 tkQTARkstGGkAPr Histone X 9701; 9711; 9606; 3465; 3642; 3377; 3475; 3458; 5764; 47398; 8481; 8552; 53348; 29237; 66065; 43185; 64522; 52725 +Mapk1 ERK2 P63085 mouse FOXO1A 56458 Q9R1E0 Foxo1 mouse T557 478373 NRLtPVKtPLQVPLS X +Mapk1 ERK2 P63085 mouse calponin 3 71994 Q9DAW9 Cnn3 mouse S293 4776192 QGtGTNGsEIsDsDy X +Mapk1 ERK2 P63085 mouse TPR 108989 F6ZDS4 Tpr mouse S2223 468982 GFAEAIHsPQVAGVP X +Mapk1 ERK2 P63085 mouse FOXO1A 56458 Q9R1E0 Foxo1 mouse S415 478369 NTSLNsPsPNYSKYT X X +Mapk1 ERK2 P63085 mouse ETV1 14009 P41164 Etv1 mouse T139 3059605 MRPSNPPtPSStPVs ETS_PEA3_N X +Mapk1 ERK2 P63085 mouse CDC42EP2 104252 Q8JZX9 Cdc42ep2 mouse S101 4270888 RELPDGLsPLLKNAI X +Mapk1 ERK2 P63085 mouse RBPMS iso2 19663 Q9WVB0-2 Rbpms mouse T118 3208560 VGtPNPStPLPNTVP X +Mapk1 ERK2 P63085 mouse AHNAK 66395 E9Q616 Ahnak mouse S2985 4693290 GPsLDIKsPKLDVNA X +Mapk1 ERK2 P63085 mouse ETV1 14009 P41164 Etv1 mouse T143 3059604 NPPtPSStPVsPLHH ETS_PEA3_N X +Mapk1 ERK2 P63085 mouse ATG2B 76559 Q80XK6 Atg2b mouse T398 21686700 YETETARtPSSREEE X +Mapk1 ERK2 P63085 mouse MAST1 56527 Q9R1L5 Mast1 mouse S1260 4784799 KsAEPPRsPLLKRVQ X +Mapk1 ERK2 P63085 mouse FRA2 14284 P47930 Fosl2 mouse S120 470354 RRRDEQLsPEEEEKR X +Mapk1 ERK2 P63085 mouse STXBP1 20910 O08599 Stxbp1 mouse S241 36440508 DRGFDPSsPVLHELT Sec1 X X +Mapk1 ERK2 P63085 mouse TPR 108989 F6ZDS4 Tpr mouse T2205 469185 EDRTVPstPtLVVPH X +Mapk1 ERK2 P63085 mouse lamin A/C 16905 P48678 Lmna mouse S22 452604 QAsstPLsPtRItRL X 2026; 13448 +Mapk1 ERK2 P63085 mouse MAPKAPK2 17164 P49138 Mapkapk2 mouse T320 448273 QsTKVPQtPLHtsRV X 3007; 3041 +Mapk1 ERK2 P63085 mouse TNF-R1 21937 P25118 Tnfrsf1a mouse S299 450967 PVSStPIsPIFGPSN X X +Mapk1 ERK2 P63085 mouse GJA1 14609 P23242 Gja1 mouse S279 448853 SsPtAPLsPMsPPGy X +Mapk1 ERK2 P63085 mouse KSR 16706 Q61097 Ksr1 mouse T260 449298 sFItPPttPQLRRHA X X +Mapk1 ERK2 P63085 mouse AHNAK 66395 E9Q616 Ahnak mouse S217 3250916 PsGsGPAsPttGsAV X +Mapk1 ERK2 P63085 mouse LARP 73158 Q6ZQ58 Larp1 mouse S751 453830 LPttVPEsPNyRNAR X +Mapk1 ERK2 P63085 mouse RIP140 268903 Q8CBD1 Nrip1 mouse T202 456686 KDQKSGPtLPDVtPN NRIP1_repr_1 X +Mapk1 ERK2 P63085 mouse TNF-R1 21937 P25118 Tnfrsf1a mouse S273 450968 PAPsPAFsPTSGFNP X X +Mapk1 ERK2 P63085 mouse CDC42EP1 104445 Q91W92 Cdc42ep1 mouse S113 3193874 SPAPPPIsPIIKNAI X +Mapk1 ERK2 P63085 mouse RAPH1 iso4 77300 F2Z3U3 Raph1 mouse S611 3203571 TSLMPPLsPQTKIIT X +Mapk1 ERK2 P63085 mouse AHNAK 66395 E9Q616 Ahnak mouse S4890 470907 KAEAPLPsPKLEGEI X +Mapk1 ERK2 P63085 mouse LOK 20868 O55098 Stk10 mouse T950 449363 EAEPRPTtPsKASNF X +Mapk1 ERK2 P63085 mouse LARP 73158 Q6ZQ58 Larp1 mouse T278 4928285 PVSVAPPtPAWQPET X +Mapk1 ERK2 P63085 mouse GJA1 24392 P08050 Gja1 rat S279 448853 SSPTAPLsPMsPPGY X +Mapk1 ERK2 P63085 mouse PR 18667 Q00175 Pgr mouse S294 447987 SPIAPGRsPLATTVV Prog_receptor X 13736 +Mapk1 ERK2 P63085 mouse ARHGEF17 207212 Q80U35 Arhgef17 mouse T695 4746259 VsPEtPPtPGALRRR X +Mapk1 ERK2 P63085 mouse FAM195B 192173 Q3UGS4 Mcrip1 mouse T30 9322247 tNssEIFtPAHEENV FAM195 X +Mapk1 ERK2 P63085 mouse FAM207A 108707 P58468 Slx9 mouse S38 4709532 VEPALPQsPAGGAGA X +Mapk1 ERK2 P63085 mouse KHDRBS1 20218 Q60749 Khdrbs1 mouse T71 449877 PPLLPPStPGPDAtV X +Mapk1 ERK2 P63085 mouse RELL1 100532 Q8K2J7 Rell1 mouse T262 3253153 VNGDVPAtPVKRERs X +Mapk1 ERK2 P63085 mouse ETV1 14009 P41164 Etv1 mouse S94 3059606 KIKKEPHsPCSELGS ETS_PEA3_N X +Mapk1 ERK2 P63085 mouse SPT5 20924 O55201 Supt5h mouse S664 468817 VGGFtPMsPRISsPM X +Mapk1 ERK2 P63085 mouse SMRT 20602 Q9WU42 Ncor2 mouse T1718 21686728 LPVLVPPtPGTPATA X +Mapk1 ERK2 P63085 mouse vinexin 20410 Q9R1Z8 Sorbs3 mouse T648 21686738 SQTQSLNtPGPTLSH X +Mapk1 ERK2 P63085 mouse ER-beta 13983 O08537 Esr2 mouse S105 447914 LYAEPQKsPWCEARS ERbeta_N X +Mapk1 ERK2 P63085 mouse RAI1 19377 Q61818 Rai1 mouse T1051 3865777 TALSEPQtPGPPGLT X +Mapk1 ERK2 P63085 mouse ELK1 13712 P41969 Elk1 mouse S384 447872 IHFWSTLsPIAPRsP X 9181; 9186 +Mapk1 ERK2 P63085 mouse DNAJC30 66114 P59041 Dnajc30 mouse T137 21686706 PPRPPPYtPRAPGGS X +Mapk1 ERK2 P63085 mouse Kv4.2 16508 Q9Z0V2 Kcnd2 mouse S616 457613 EGDDRPEsPEYsGGN X +Mapk1 ERK2 P63085 mouse FOXO3A 56484 Q9WVH4 Foxo3 mouse S293 472326 QLSkWPGsPTSRssD X 5538 +Mapk1 ERK2 P63085 mouse SAFB1 224903 D3YXK2 Safb mouse S366 468668 RAPtAALsPEPQDsK X +Mapk1 ERK2 P63085 mouse MEK1 26395 P31938 Map2k1 mouse T292 448287 EtPPRPRtPGRPLsS Pkinase X X 26975 +Mapk1 ERK2 P63085 mouse WIZ 22404 O88286 Wiz mouse S1016 4699701 GLTHPsssPLLKKAP X +Mapk1 ERK2 P63085 mouse BAT2 53761 Q7TSC1 Prrc2a mouse S1217 452699 KLISGPLsPMsRAGN X +Mapk1 ERK2 P63085 mouse NR4A2 4929 P43354 NR4A2 human S126 487424 SVYYKPssPPtPTtP X +Mapk1 ERK2 P63085 mouse SNED1 208777 Q70E20 Sned1 mouse T1239 21686730 NDHSAPEtPTQSSRF X +Mapk1 ERK2 P63085 mouse 4E-T 74203 Q9EST3 Eif4enif1 mouse S114 21686708 DDLDVVLsPQRRsFG EIF4E-T X +Mapk1 ERK2 P63085 mouse AKAP12 83397 Q9WTQ5 Akap12 mouse S273 476342 KPLEsPtsPVSNETT X +Mapk1 ERK2 P63085 mouse KSR 16706 Q61097 Ksr1 mouse S443 449300 TTSSTPSsPAPFLTS X X +Mapk1 ERK2 P63085 mouse MAP1A 17754 Q9QYR6 Map1a mouse T2182 481116 ALALVPGtPtRtRHD X +Mapk1 ERK2 P63085 mouse DLG5 71228 E9Q9R9 Dlg5 mouse T1279 3843835 ERIKIPLtPRYPRSV X +Mapk1 ERK2 P63085 mouse PAR3-alpha 81918 Q9Z340 Pard3 rat S1116 28758704 ALNARPQsPREGHLM X +Mapk1 ERK2 P63085 mouse BIM 12125 O54918 Bcl2l11 mouse S65 449330 GPLAPPAsPGPFATR X 4581; 4585 +Mapk1 ERK2 P63085 mouse FOXO1A 56458 Q9R1E0 Foxo1 mouse S413 478368 PPNTSLNsPsPNYSK X X +Mapk1 ERK2 P63085 mouse p53 22059 P02340 Tp53 mouse S18 447490 IsLELPLsQEtFsGL P53_TAD X X 9284; 9286; 12571; 56979 +Mapk1 ERK2 P63085 mouse Spinophilin 217124 Q6R891 Ppp1r9b mouse S15 455339 GPGGPLRsAsPHRSA X X +Mapk1 ERK2 P63085 mouse ELYS 226747 Q8CJF7 Ahctf1 mouse T1954 14573029 TGLDVPAtPRKRGRP X +Mapk1 ERK2 P63085 mouse XRN2 24128 Q9DBR1 Xrn2 mouse T439 3211959 FTPSGILtPHALGsR XRN_M X +Mapk1 ERK2 P63085 mouse AHNAK 66395 E9Q616 Ahnak mouse T695 10788942 LPEVsVKtPKIsMPD X +Mapk1 ERK2 P63085 mouse PKCA 18750 P20444 Prkca mouse T638 448685 TRGQPVLtPPDQLVI Pkinase_C X X 9375 +Mapk1 ERK2 P63085 mouse FRA2 14284 P47930 Fosl2 mouse S230 452625 QEPPEEDsPSSSAGM X +Mapk1 ERK2 P63085 mouse BIK 12124 O70337 Bik mouse T116 25171001 IWSWRVLtPGAWVSP bcl-2I13 X +Mapk1 ERK2 P63085 mouse MYO9B 17925 Q9QY06 Myo9b mouse T1317 1983800 RATGAALtPtEERRI X +Mapk1 ERK2 P63085 mouse KLF4 16600 Q60793 Klf4 mouse S132 24976100 ASASSSSsPASSGPA X +Mapk1 ERK2 P63085 mouse NR4A2 4929 P43354 NR4A2 human T132 487426 ssPPtPTtPGFQVQH X +Mapk1 ERK2 P63085 mouse GJA1 24392 P08050 Gja1 rat S255 448852 HATTGPLsPskDCGs X +Mapk1 ERK2 P63085 mouse NIPA 232679 Q80YV2 Zc3hc1 mouse S358 483339 tRsWEsssPVDRPEL X +Mapk1 ERK2 P63085 mouse p90RSK 20111 P18653 Rps6ka1 mouse S369 447990 HQLFRGFsFVATGLM Pkinase_C X 9341; 9335; 13575; 11989; 12032; 75266; 93317; 13397; 13588 +Mapk1 ERK2 P63085 mouse hnRNP H2 56258 P70333 Hnrnph2 mouse S104 455396 LKHtGPNsPDtANDG X +Mapk1 ERK2 P63085 mouse NR4A2 4929 P43354 NR4A2 human T129 487425 YKPssPPtPTtPGFQ X +Mapk1 ERK2 P63085 mouse AIM1 11630 E9PVP1 Crybg1 mouse T655 8143602 QDATsPLtPTRLLNI X +Mapk1 ERK2 P63085 mouse Cofilin-1 12631 P18760 Cfl1 mouse T25 7990494 MkVRKSstPEEVKkR Cofilin_ADF X X +Mapk1 ERK2 P63085 mouse Ets-1 23871 P27577 Ets1 mouse S41 22650305 VPLLtPSsKEMMSQA X +Mapk1 ERK2 P63085 mouse NICE-4 74383 Q80X50 Ubap2l mouse T864 449365 IPFPtPTtPLTGRDG X +Mapk1 ERK2 P63085 mouse TPR 108989 F6ZDS4 Tpr mouse T2184 4743148 VGrGLQLtPGIGGMQ X +Mapk1 ERK2 P63085 mouse H3 iso3 15081 P84244 H3f3b mouse S28 455677 ATkAArksAPSTGGV Histone X 9713 +Mapk1 ERK2 P63085 mouse SUPV3L1 338359 Q80YD1 Supv3l1 mouse S725 3245612 NKATEPLsPSDKELP X +Mapk1 ERK2 P63085 mouse Fos 314322 P12841 Fos rat T325 448483 TELEPLCtPVVTCtP X +Mapk1 ERK2 P63085 mouse JunB 16477 P09450 Junb mouse S256 452631 RDAtPPVsPINMEDQ X +Mapk1 ERK2 P63085 mouse DCP1A 75901 Q91YD3 Dcp1a mouse S339 3213297 LPLsPVLsPTLPAEA X +Mapk1 ERK2 P63085 mouse TBC1D23 67581 Q8K0F1 Tbc1d23 mouse T514 483869 sFIENSStPVDRHVs TBC1D23_C X +Mapk1 ERK2 P63085 mouse DNCLI1 235661 Q8R1Q8 Dync1li1 mouse S516 449258 VsPttPtsPtEGEAs DLIC X +Mapk1 ERK2 P63085 mouse TFPI 21788 O54819 Tfpi mouse S210 21686734 NNIVVPQsPKVPRRR X +Mapk1 ERK2 P63085 mouse TANC1 66860 Q0VGY8 Tanc1 mouse S1561 9831758 SSQNPPPsPMPGRVS X +Mapk1 ERK2 P63085 mouse HIF1A 3091 Q16665 HIF1A human S643 470106 kILIAsPsPTHIHkE X +Mapk1 ERK2 P63085 mouse FBXW7 55294 Q969H0 FBXW7 human S176 25126709 KRKLDHGsEVRSFSL X +Mapk1 ERK2 P63085 mouse girdin 55704 Q3V6T2 CCDC88A human S233 4725929 HASSSAQsPCGsPGM X +Mapk1 ERK2 P63085 mouse STMN1 16765 P54227 Stmn1 mouse S38 448556 sVPdFPLsPPKKKDL Stathmin X 3426; 4191 +Mapk1 ERK2 P63085 mouse FRA2 14284 P47930 Fosl2 mouse S320 4707550 QSSDSLNsPtLLAL_ X +Mapk1 ERK2 P63085 mouse BAT2 53761 Q7TSC1 Prrc2a mouse T609 452701 EEVPPPttPPAPKME X +Mapk1 ERK2 P63085 mouse STXBP1 20910 O08599 Stxbp1 mouse T574 454395 IGSTHILtPQKLLDt Sec1 X +Mapk1 ERK2 P63085 mouse RPS3 27050 P62908 Rps3 mouse T221 452652 kDEILPttPIsEQkG X +Mapk1 ERK2 P63085 mouse MAST4 328329 Q811L6 Mast4 mouse S1436 4749578 KsAEPPRsPLLKRVQ X +Mapk1 ERK2 P63085 mouse NFAT3 73181 Q8K120 Nfatc4 mouse S676 455348 SNGRRKRsPTQSFKF RHD_dimer X +Mapk1 ERK2 P63085 mouse Bcl-2 12043 P10417 Bcl2 mouse S70 448395 RDMAARtsPLRPLVA X +Mapk1 ERK2 P63085 mouse FAK 14083 P34152 Ptk2 mouse S910 447964 KLQPQEIsPPPTANL X X +Mapk1 ERK2 P63085 mouse STF-1 26423 P33242 Nr5a1 mouse S203 447603 EYPEPYAsPPQQPGP X +Mapk1 ERK2 P63085 mouse IRS2 384783 P81122 Irs2 mouse T653 15228280 DDGyMPMtPGAALRs X +Mapk1 ERK2 P63085 mouse UBAP2 68926 Q91VX2 Ubap2 mouse T964 21686736 VALSTPPtPFQQASG X +Mapk1 ERK2 P63085 mouse PHLDB1 102693 Q6PDH0 Phldb1 mouse S445 468424 RTLQPPEsPRLGRRG X +Mapk1 ERK2 P63085 mouse GTSE1 29870 Q8R080 Gtse1 mouse S460 4763255 PQFSVGEsPGGVtPK X +Mapk1 ERK2 P63085 mouse RAI14 75646 Q9EP71 Rai14 mouse T249 486552 SQDADLKtPtKPKQH Ank_2 X +Mapk1 ERK2 P63085 mouse girdin 55704 Q3V6T2 CCDC88A human S237 4725935 SAQsPCGsPGMKRTE X +Mapk1 ERK2 P63085 mouse DLG7 218977 Q8K4R9 Dlgap5 mouse S328 456337 SYQVAPLsPRSANAF X +Mapk1 ERK2 P63085 mouse ATF-2 11909 P16951 Atf2 mouse T53 448225 IVADQtPtPtRFLKN X X 9225; 9221; 5112; 94125; 13850; 40749; 15411; 24329; 61584; 27934; 92109; 20534; 35858 +Mapk1 ERK2 P63085 mouse FOXO1A 56458 Q9R1E0 Foxo1 mouse S467 478371 KELLtsDsPPHNDIM FOXO_KIX_bdg X X +Mapk1 ERK2 P63085 mouse TNF-R1 21937 P25118 Tnfrsf1a mouse S269 451128 KPLtPAPsPAFsPTS X X +Mapk1 ERK2 P63085 mouse TPX2 72119 A2APB8 Tpx2 mouse T369 455432 KIARDPQtPILQtKY TPX2_importin X +Mapk1 ERK2 P63085 mouse MAP1B 17755 P14873 Map1b mouse T1784 456417 ksDIsPLtPREssPL X +Mapk1 ERK2 P63085 mouse TNF-R1 21937 P25118 Tnfrsf1a mouse T265 450966 EKAGKPLtPAPsPAF X X +Mapk1 ERK2 P63085 mouse SHC1 20416 P98083 Shc1 mouse S36 448508 TPPEELPsPSASSLG X +Mapk1 ERK2 P63085 mouse Ets-1 23871 P27577 Ets1 mouse T38 447950 CADVPLLtPSsKEMM X +Mapk1 ERK2 P63085 mouse p70S6K 6198 P23443 RPS6KB1 human S434 448356 sFEPKIRsPRRFIGs X +Mapk1 ERK2 P63085 mouse AHNAK 66395 E9Q616 Ahnak mouse S4906 7103416 VPDVDIssPGINVEA X +Mapk1 ERK2 P63085 mouse STMN1 16765 P54227 Stmn1 mouse S25 448555 QAFELILsPRskEsV Stathmin X X +Mapk1 ERK2 P63085 mouse C/EBP-beta 12608 P28033 Cebpb mouse T188 447878 sSssPPGtPSPADAK X X 3084 +Mapk1 ERK2 P63085 mouse NOXA1 241275 Q8CJ00 Noxa1 mouse Y252 1869151102 GHTSPGLyDSLLASR X +Mapk1 ERK2 P63085 mouse BIM 12125 O54918 Bcl2l11 mouse S100 449602 FSFDTDRsPAPMsCD X +Mapk1 ERK2 P63085 mouse RCAN1 54720 Q9JHG6 Rcan1 mouse S165 456023 FLIsPPAsPPVGWKQ Calcipressin X +Mapk1 ERK2 P63085 mouse PCYT1A 140544 P19836 Pcyt1a rat S315 451321 GRMLQAIsPKQsPss X +Mapk1 ERK2 P63085 mouse EGFR 13649 Q01279 Egfr mouse T695 448054 RELVEPLtPsGEAPN X 3056; 8808 +Mapk1 ERK2 P63085 mouse CEP170B 217882 Q80U49 Cep170b mouse T968 485661 KNGPsPTtPQtPGPQ CEP170_C X +Mapk1 ERK2 P63085 mouse FOXO1A 56458 Q9R1E0 Foxo1 mouse S284 478910 GQEGPGDsPGSQFSK X +Mapk1 ERK2 P63085 mouse DOCK1 330662 Q8BUR4 Dock1 mouse T1772 3801979 QQtPPPVtPRAKLSF X +Mapk1 ERK2 P63085 mouse REXO1 66932 Q7TT28 Rexo1 mouse T259 21686724 SRGAEPYtPALkKPC X +Mapk1 ERK2 P63085 mouse CEP170B 217882 Q80U49 Cep170b mouse T529 3843372 PVLPAPLtPRGAsPV X +Mapk1 ERK2 P63085 mouse MYBBP1A 18432 Q7TPV4 Mybbp1a mouse S1280 459879 VNGAtPVsPIEPEsK X +Mapk1 ERK2 P63085 mouse ETV3 27049 Q8R4Z4 Etv3 mouse S139 14159952 SSGVVPQsAPPVPTA X +Mapk1 ERK2 P63085 mouse SMAD4 17128 P97471 Smad4 mouse T276 449628 GSRTAPYtPNLPHHQ X X +Mapk1 ERK2 P63085 mouse NDEL1 83431 Q9ERR1 Ndel1 mouse T219 468252 ASLsLPAtPVGKGTE NUDE_C X +Mapk1 ERK2 P63085 mouse FOXO1A 56458 Q9R1E0 Foxo1 mouse S246 471071 EGGkSGksPRRRAAs X X +Mapk1 ERK2 P63085 mouse GLI2 14633 Q0VGT2 Gli2 mouse T885 21686712 ATGGPPPtPLPGLDR X +Mapk1 ERK2 P63085 mouse ELK1 2002 P19419 ELK1 human S383 447872 IHFWSTLsPIAPRsP X 9181; 9186 +Mapk1 ERK2 P63085 mouse RAPH1 iso4 77300 F2Z3U3 Raph1 mouse T879 5518475 SQFPPPPtPPPVDSQ X +Mapk1 ERK2 P63085 mouse Jun 16476 P05627 Jun mouse S246 450451 PGEtPPLsPIDMESQ X 2994 +Mapk1 ERK2 P63085 mouse MEK1 26395 P31938 Map2k1 mouse T386 448288 IGLNQPstPtHAASI X X +Mapk1 ERK2 P63085 mouse TH 25085 P04177 Th rat S31 448544 KQAEAVtsPRFIGRR TOH_N X 3370; 13041 +Mapk1 ERK2 P63085 mouse p53 7157 P04637 TP53 human S15 447490 PsVEPPLsQEtFsDL P53_TAD X 4030; 9235; 9284; 9286; 8695; 8514; 82530; 56979 +Mapk1 ERK2 P63085 mouse PLA2G4A 18783 P47713 Pla2g4a mouse S505 447597 LNTSYPLsPLRDFss PLA2_B X 2831; 53044 +Mapk1 ERK2 P63085 mouse MEK1 100009316 P29678 MAP2K1 rabbit T292 448287 ETPPRPRtPGRPLsS Pkinase X +Mapk1 ERK2 P63085 mouse GATA4 14463 Q08369 Gata4 mouse S105 449604 AYTPPPVsPRFSFPG GATA-N X +Mapk1 ERK2 P63085 mouse Nur77 79240 P22829 Nr4a1 rat T142 15068600 CSAPSPPtPNFQPSQ X +Mapk1 ERK2 P63085 mouse RBM9 93686 Q8BP71 Rbfox2 mouse T65 5968614 GMQNEPLtPGYHGFP X +Mapk1 ERK2 P63085 mouse Nogo 68585 Q99P72 Rtn4 mouse T156 15412809 EPAAPPStPAAPKRR X +Mapk1 ERK2 P63085 mouse RRas 6237 P10301 RRAS human S201 18015221 QEQELPPsPPsAPRK X +Mapk1 ERK2 P63085 mouse AHNAK 66395 E9Q616 Ahnak mouse T5567 3148545 REFsAPstPtGtLEF X +Mapk1 ERK2 P63085 mouse HIF1A 3091 Q16665 HIF1A human S641 470105 DIkILIAsPsPTHIH X +Mapk1 ERK2 P63085 mouse RIP140 268903 Q8CBD1 Nrip1 mouse T207 455626 GPtLPDVtPNLIRDS NRIP1_repr_1 X +Mapk1 ERK2 P63085 mouse Ets-2 23872 P15037 Ets2 mouse T72 447688 SCELPLLtPCSKAVM X +Mapk1 ERK2 P63085 mouse OGA 76055 Q9EQQ9 Oga mouse T709 472476 FFQPPPLtPTSKVYT X +Mapk1 ERK2 P63085 mouse KHDRBS1 20218 Q60749 Khdrbs1 mouse S58 449876 PrGGArAsPAtQPPP X +Mapk1 ERK2 P63085 mouse Kv7.2 3785 O43526 KCNQ2 human S414 58948900 KDPPPEPsPSKGSPC X X +Mapk1 ERK2 P63085 mouse BIM 12125 O54918 Bcl2l11 mouse T112 449071 sCDKStQtPsPPCQA X +Mapk1 ERK2 P63085 mouse ERF 13875 P70459 Erf mouse T529 448321 GEsGGPLtPRRVssD X +Mapk1 ERK2 P63085 mouse NUP153 218210 Q80WR0 Nup153 mouse T610 3191095 sVLDILktPGFAsPK Nup153 X +Mapk1 ERK2 P63085 mouse FOXO1A 56458 Q9R1E0 Foxo1 mouse S295 471972 QFSKWPAsPGSHsND X +Mapk1 ERK2 P63085 mouse K8 3856 P05787 KRT8 human S432 448540 sAyGGLtsPGLsysL X +Mapk1 ERK2 P63085 mouse DCP1A 75901 Q91YD3 Dcp1a mouse S335 3213294 PsYTLPLsPVLsPTL X +Mapk1 ERK2 P63085 mouse UGDH 22235 O70475 Ugdh mouse T474 469003 SSKRIPytPGEIPkF X +Mapk1 ERK2 P63085 mouse KHDRBS1 20218 Q60749 Khdrbs1 mouse T84 449878 tVVGSAPtPLLPPSA X +Mapk1 ERK2 P63085 mouse NR4A2 4929 P43354 NR4A2 human T185 487427 FKQsPPGtPVSSCQM X +Mapk1 ERK2 P63085 mouse Caldesmon 800 Q05682 CALD1 human S789 448466 QsVDKVtsPtKV___ X +Mapk1 ERK2 P63085 mouse GJA1 14609 P23242 Gja1 mouse S255 448852 HAtTGPLsPskDCGs X +Mapk1 ERK2 P63085 mouse STAT1 20846 P42225 Stat1 mouse S727 447753 tDNLLPMsPEEFDEM STAT1_TAZ2bind X X 9177; 8826; 62390 +Mapk1 ERK2 P63085 mouse RIPK3 56532 Q9QZL0 Ripk3 mouse T399 21686726 tLPFRGTtPGPVFTE X +Mapk1 ERK2 P63085 mouse TH 21823 P24529 Th mouse S31 448544 KQAEAVtsPRFIGRR TOH_N X 3370; 13041 +NEK10 NEK10 Q6ZWH5 human RYR1 20190 E9PZQ0 Ryr1 mouse T4338 34348504 ALLWALVtRAGGAGA X +Cdk1 CDK1 P11440 mouse MCM4 17217 P49717 Mcm4 mouse T109 450002 PRsGVRGtPVRQRPD X +Cdk1 CDK1 P11440 mouse C/EBP-alpha 12606 P53566 Cebpa mouse S193 1868113505 PPPHPHAsPAHLAAP X X +Cdk1 CDK1 P11440 mouse MyoD 17927 P10085 Myod1 mouse S5 470072 ___MELLsPPLRDID X X +Cdk1 CDK1 P11440 mouse POLR2A 20020 P08775 Polr2a mouse S1616 450204 TPQSPSYsPtsPSYS RNA_pol_Rpb1_R X 4735; 13499; 13546; 31262 +Cdk1 CDK1 P11440 mouse MyoD 17927 P10085 Myod1 mouse S200 40684505 SGDSDASsPRsNCSD Myf5 X X +Cdk1 CDK1 P11440 mouse PAK1 18479 O88643 Pak1 mouse T212 448176 VIEPLPVtPtRDVAt X +Cdk1 CDK1 P11440 mouse lamin A/C 16905 P48678 Lmna mouse S392 452606 ERLRLsPsPtsQRsR X +Cdk1 CDK1 P11440 mouse FOXO1A 2308 Q12778 FOXO1 human S249 471071 EGGkSGksPrRrAAs X +Cdk1 CDK1 P11440 mouse MSX1 17701 P13297 Msx1 mouse S136 50783957 DALVkAEsPEKLDRT X +Cdk1 CDK1 P11440 mouse MCM3 17215 P25206 Mcm3 mouse T719 449197 tQMPQVHtPKtDDsQ X +Cdk1 CDK1 P11440 mouse C/EBP-alpha 12606 P53566 Cebpa mouse S21 448308 PMSSHLQsPPHAPSN X 2841 +Cdk1 CDK1 P11440 mouse SYN3 8224 O14994 SYN3 human S470 455901 PQGQQPLsPQsGsPQ X +Cdk1 CDK1 P11440 mouse desmin 395906 P02542 DES chicken T64 1868158502 TFRTTRVtPLRTYGS Filament_head X +Cdk1 CDK1 P11440 mouse Vimentin 101824289 P02544 Vim hamster S55 451514 SRSLYSSsPGGAYVT Filament_head X +Cdk1 CDK1 P11440 mouse CK2B 100873151 P67869 CSNK2B chicken S209 451751 QAASNFKsPVKTIR_ X +Cdk1 CDK1 P11440 mouse MCM4 17217 P49717 Mcm4 mouse T19 448634 SSRRGRVtPtQsLRs X +Cdk1 CDK1 P11440 mouse CREM 12916 P27699 Crem mouse S290 450066 AsPGsLHsPQQLAEE X X +Cdk1 CDK1 P11440 mouse SOX2 20674 P48432 Sox2 mouse S39 18913847 TGGNQkNsPDRVKRP X +Cdk1 CDK1 P11440 mouse K5 110308 Q922U2 Krt5 mouse T145 288031706 TVNQNLLtPLNLQID Keratin_2_head X +Cdk1 CDK1 P11440 mouse Abl 11350 P00520 Abl1 mouse S569 450293 LDSEPAVsPLLPRKE X +Cdk1 CDK1 P11440 mouse K5 110308 Q922U2 Krt5 mouse T24 15420502 FsAAsAItPsVsRTs Keratin_2_head X X +Cdk1 CDK1 P11440 mouse Vimentin 22352 P20152 Vim mouse S56 451514 sRsLysssPGGAyVt Filament_head X 3877; 7391 +Cdk1 CDK1 P11440 mouse desmin 395906 P02542 DES chicken S6 466342 __SQSYSsSQRVSsY X +Cdk1 CDK1 P11440 mouse PPP1R1A 58200 Q9ERT9 Ppp1r1a mouse S67 447758 LKSTLsMsPRQRKKM DARPP-32 X +Cdk1 CDK1 P11440 mouse C/EBP-beta 24253 P21272 Cebpb rat S64 456166 HERAIDFsPYLEPLA X +Cdk1 CDK1 P11440 mouse BAD 12015 Q61337 Bad mouse S128 447861 EGMEEELsPFRGRsR Bcl-2_BAD X +Cdk1 CDK1 P11440 mouse PPP1CA 19045 P62137 Ppp1ca mouse T320 448686 NPGGRPItPPRNsAK X X +Cdk1 CDK1 P11440 mouse CREM 12916 P27699 Crem mouse S284 450065 QGVVMAAsPGsLHsP X X +Cdk1 CDK1 P11440 mouse Src iso1 20779 P05480-1 Src mouse S74 450326 NSSDtVTsPQRAGPL X +Cdk1 CDK1 P11440 mouse UBE1 7317 P22314 UBA1 human S4 449950 ____MSssPLsKKRR X X +Cdk1 CDK1 P11440 mouse talin 1 21894 P26039 Tln1 mouse S1589 27533485 SSVPAQIsPEGRAAM X +Cdk1 CDK1 P11440 mouse CREM 12916 P27699 Crem mouse S133 448412 EILSRRPsYRKILNE pKID X 4095; 14228; 14001 +Cdk1 CDK1 P11440 mouse MCM4 17217 P49717 Mcm4 mouse T7 450000 _MssPAstPsRRSSR X +Cdk1 CDK1 P11440 mouse Plectin-1 64204 P30427 Plec rat T4542 451386 GGLIEPDtPGRVSLD Plectin X +Cdk1 CDK1 P11440 mouse POLR2A 20020 P08775 Polr2a mouse S1619 447616 SPSYsPtsPSYSPTS RNA_pol_Rpb1_R X 4735; 13523; 13546; 67221 +Cdk1 CDK1 P11440 mouse CDK7 12572 Q03147 Cdk7 mouse S164 450041 GLAKsFGsPNRAytH Pkinase X +Cdk1 CDK1 P11440 mouse desmin 13346 P31001 Des mouse S32 466343 sLGsPLssPVFPrAG Filament_head X +Cdk1 CDK1 P11440 mouse CDK1 12534 P11440 Cdk1 mouse Y15 447610 EKIGEGtyGVVyKGR Pkinase X 4539; 9111; 14566; 77897 +Cdk1 CDK1 P11440 mouse CREM 12916 P27699 Crem mouse S156 450064 PKIEEEKsEEEGTPP X X +Cdk1 CDK1 P11440 mouse FOXO1A 56458 Q9R1E0 Foxo1 mouse S246 471071 EGGkSGksPRRRAAs X +Cdk1 CDK1 P11440 mouse MCM4 17217 P49717 Mcm4 mouse S87 460696 PLDFDVSsPLTYGTP X +Cdk1 CDK1 P11440 mouse Abl 11350 P00520 Abl1 mouse T547 450294 EQKDAPDtPELLHTK X +Cdk1 CDK1 P11440 mouse MCM4 17217 P49717 Mcm4 mouse S32 450001 RsEESRssPNRRRRG X +Cdk1 CDK1 P11440 mouse desmin 395906 P02542 DES chicken S22 466343 RTFGGGTsPVFPRAs Filament_head X +Cdk1 CDK1 P11440 mouse MCM3 17215 P25206 Mcm3 mouse S112 2840507 SFGSKHVsPRTLTSC MCM_OB X 12686 +Cdk1 CDK1 P11440 mouse Vimentin 7431 P08670 VIM human S56 451514 srsLyAssPGGVyAt Filament_head X 3877; 7391 +Rps6kb1 p70S6K P67999 rat GSK3B 84027 P18266 Gsk3b rat S9 449111 SGRPRTTsFAESCKP X 9336; 9331; 9327; 9323; 9322; 9325; 5558; 8566; 79774; 8466; 25462; 14026; 14332; 14310; 14630 +Rps6kb1 p70S6K P67999 rat SREBP-1 iso1 78968 P56720-1 Srebf1 rat S419 56654316 LGSRGSssGGsDsEP X +Rps6kb1 p70S6K P67999 rat S6 29304 P62755 Rps6 rat S235 448092 IAKRRRLssLRAsts X 5006; 4856; 4857; 4858; 4851; 4803; 2211; 3945; 3985; 5316; 4854; 8520; 48319; 40643; 9865; 38573; 14733; 27036; 34411; 62016; 62788; 81736; 97935; 99457; 15448 +Rps6kb1 p70S6K P67999 rat S6 6194 P62753 RPS6 human S240 448094 RLssLRAstsKsEss X 2215; 5364; 5018; 93315; 5044; 13020; 14236; 9468; 35708; 88441; 34918 +Rps6kb1 p70S6K P67999 rat SREBP-1 iso1 78968 P56720-1 Srebf1 rat S418 1869370300 SLGSRGSssGGsDsE X +Rps6kb1 p70S6K P67999 rat BAD 64639 O35147 Bad rat S137 447862 PFRGRsRsAPPNLWA Bcl-2_BAD X 9295; 5286; 4366 +Rps6kb1 p70S6K P67999 rat PFKFB2 287019 P26285 PFKFB2 cow S484 452046 IRRPRNYsVGSRPLQ X +Rps6kb1 p70S6K P67999 rat SREBP-1 iso1 78968 P56720-1 Srebf1 rat S422 4785186 RGSssGGsDsEPDSP X +Rps6kb1 p70S6K P67999 rat S6 6194 P62753 RPS6 human S244 448095 LRAstsKsEssQK__ X 2215; 5364; 5018; 93315; 5044; 13020; 14236; 9468; 35708; 88441; 34918 +Rps6kb1 p70S6K P67999 rat S6 29304 P62755 Rps6 rat S240 448094 RLssLRAstsKsESs X 2215; 5364; 5018; 93315; 5044; 13020; 14236; 9468; 35708; 88441; 34918 +Rps6kb1 p70S6K P67999 rat S6 29304 P62755 Rps6 rat S236 448093 AKRRRLssLRAstsK X 5006; 4856; 4857; 4858; 4851; 4803; 2211; 3945; 3985; 5316; 4854; 8520; 48319; 40643; 9865; 38573; 14733; 27036; 34411; 62016; 62788; 81736; 97935; 99457; 15448 +Rps6kb1 p70S6K P67999 rat PFKFB2 287019 P26285 PFKFB2 cow S467 448460 PVRMRRNsFTPLSSS X +Rps6kb1 p70S6K P67999 rat S6 29304 P62755 Rps6 rat S244 448095 LRAstsKsESsQK__ X 2215; 5364; 5018; 93315; 5044; 13020; 14236; 9468; 35708; 88441; 34918 +PAK3 PAK3 O75914 human MYO6 397085 Q29122 MYO6 pig T406 449089 TAGGAKGtVIKVPLK Myosin_head X +PAK3 PAK3 O75914 human GluR1 50592 P19490 Gria1 rat S863 448566 TSTLPRNsGAGASGG X 8084 +PAK3 PAK3 O75914 human Caldesmon 373965 P12957 CALD1 chicken S702 456707 GLKVGVSsRINEWLT Caldesmon X +PAK3 PAK3 O75914 human Caldesmon 373965 P12957 CALD1 chicken S672 456706 EGVRNIKsMWEKGNV Caldesmon X +PAK3 PAK3 O75914 human PAK3 18481 Q61036 Pak3 mouse S154 448123 VNNQKYMsFTSGDKs X 2606 +PAK3 PAK3 O75914 human MEK1 170851 Q01986 Map2k1 rat S298 448284 RtPGRPLsSYGMDSR Pkinase X 9128; 98195 +Dyrk1b DYRK1B Q9Z188 mouse CCND1 12443 P25322 Ccnd1 mouse T286 447839 EEAGLACtPtDVRDV X X +Dyrk1b DYRK1B Q9Z188 mouse p27Kip1 12576 P46414 Cdkn1b mouse S10 447874 NVRVsNGsPsLERMD X X +Dyrk1b DYRK1B Q9Z188 mouse NKX3-1 4824 Q99801 NKX3-1 human S185 4825101 KTKRkQLssELGDLE X +Dyrk1b DYRK1B Q9Z188 mouse CCND1 12443 P25322 Ccnd1 mouse T288 451435 AGLACtPtDVRDVDI X X +PHKG1 PHKG1 P00518 rabbit PHKA1 100303771 P18688 PHKA1 rabbit S972 455914 KEFGVERsVRPTDSN X +PHKG1 PHKG1 P00518 rabbit Tau iso8 4137 P10636-8 MAPT human S262 447930 NVKskIGstENLkHQ Tubulin-binding X +PHKG1 PHKG1 P00518 rabbit TNNT3 100009527 P02641 TNNT3 rabbit S2 466430 ______MsDEEVEHV X +PHKG1 PHKG1 P00518 rabbit PYGM 100008972 P00489 PYGM rabbit S15 449838 QEKRKQIsVRGLAGV X +PHKG1 PHKG1 P00518 rabbit PHKA1 100303771 P18688 PHKA1 rabbit S1007 455916 TGIMQLKsEIKQVEF X +PHKG1 PHKG1 P00518 rabbit TNNT3 100009527 P02641 TNNT3 rabbit S170 1067211 KKKKALSsMGANYSs Troponin X +PHKG1 PHKG1 P00518 rabbit TNNT3 100009527 P02641 TNNT3 rabbit S177 1067210 sMGANYSsYLAKADQ Troponin X +PHKG1 PHKG1 P00518 rabbit PHKG1 100009297 P00518 PHKG1 rabbit S31 455918 EILGRGVsSVVRRCI Pkinase X +PHKG1 PHKG1 P00518 rabbit PHKA1 100303771 P18688 PHKA1 rabbit S985 455915 SNVSPAIsIHEIGAV X +PHKG1 PHKG1 P00518 rabbit GYS1 100008660 P13834 GYS1 rabbit S8 449898 MPLSRTLsVSsLPGL X +Rock2 ROCK2 Q62868 rat ROCK2 25537 Q62868 Rock2 rat T414 5931301 QLPFIGFtYFRENLL X +Rock2 ROCK2 Q62868 rat SNAP-25 20614 P60879 Snap25 mouse T138 449875 GGFIRRVtNDARENE SNAP-25 X +Rock2 ROCK2 Q62868 rat MYPT1 116670 Q10728 Ppp1r12a rat S854 451999 RPREKRRstGVSFWT X +Rock2 ROCK2 Q62868 rat CLCN3 iso2 84360 P51792-2 Clcn3 rat T532 51381106 LGGVTRMtVSLVVIV Voltage_CLC X +Rock2 ROCK2 Q62868 rat MYPT1 116670 Q10728 Ppp1r12a rat T697 448587 ARQSRRstQGVTLTD X 5163 +DYRK1B DYRK1B Q9Y463 human HDAC5 15184 Q9Z2V6 Hdac5 mouse S270 4788487 KVAERRssPLLRRKD X +DYRK1B DYRK1B Q9Y463 human ID2 3398 Q02363 ID2 human T27 4706880 LGISRSKtPVDDPMS X +DYRK1B DYRK1B Q9Y463 human DYRK1B 9149 Q9Y463 DYRK1B human Y271 458096 CQLGQRIyQyIQsRF Pkinase X X +DYRK1B DYRK1B Q9Y463 human NKX3-1 4824 Q99801 NKX3-1 human S186 7998431 TKRkQLssELGDLEK X +DYRK1B DYRK1B Q9Y463 human p21Cip1 1026 P38936 CDKN1A human S153 456134 sMTDFyHskRrLIFS X X +DYRK1B DYRK1B Q9Y463 human HNF1A 6927 P20823 HNF1A human S249 451310 IQRGVsPsQAQGLGS X +DYRK1B DYRK1B Q9Y463 human NKX3-1 4824 Q99801 NKX3-1 human S185 4825101 KTKRkQLssELGDLE X +DYRK1B DYRK1B Q9Y463 human DYRK1B 9149 Q9Y463 DYRK1B human Y273 449567 LGQRIyQyIQsRFYR Pkinase X X +DYRK1B DYRK1B Q9Y463 human H3F3A 3020 P84243 H3-3A human T45 18545304 PHryrPGtVALrEIR Histone X +DYRK1B DYRK1B Q9Y463 human EHMT2 10919 Q96KQ7 EHMT2 human T555 3827109 IPRGDGVtPPAGtAA X +DYRK1B DYRK1B Q9Y463 human CCND1 595 P24385 CCND1 human T288 451435 VDLACtPtDVRDVDI X +DYRK1B DYRK1B Q9Y463 human DYRK1B 9149 Q9Y463 DYRK1B human S421 50269512 YEPAARIsPLGALQH Pkinase X +DYRK1B DYRK1B Q9Y463 human GYS1 100008660 P13834 GYS1 rabbit S641 448237 YRYPRPAsVPPsPSL Glycogen_syn X X +DYRK1B DYRK1B Q9Y463 human LIN52 91750 Q52LA3 LIN52 human S28 4758466 FEKLDRAsPDLWPEQ LIN52 X +DYRK1B DYRK1B Q9Y463 human SF3B1 23451 O75533 SF3B1 human T434 460652 PARkLtAtPtPLGGM SF3b1 X +MAST4 MAST4 O15021 human SOX9 20682 Q04887 Sox9 mouse S492 1877718900 PSIPQTHsPQHWEQP X +MKNK2 Mnk2 Q9HBH9 human SynGAP 240057 F6SEU4 Syngap1 mouse S788 19014968 MDMARLPsPtKEkPP DUF3498 X +MKNK2 Mnk2 Q9HBH9 human PSF 6421 P23246 SFPQ human S283 3182056 EGFkANLsLLRRPGE X +MKNK2 Mnk2 Q9HBH9 human PSF 6421 P23246 SFPQ human S8 25802101 MSRDRFrsrGGGGGG X +MKNK2 Mnk2 Q9HBH9 human SPRY2 10253 O43597 SPRY2 human S112 465675 APLSRSIsTVssGsR X +MKNK2 Mnk2 Q9HBH9 human EIF4E 1977 P06730 EIF4E human S209 447776 DtATksGsttKNRFV X X 9741 +MKNK2 Mnk2 Q9HBH9 human Plectin-1 5339 Q15149 PLEC human S4642 3196844 RAGsRrGsFDAtGsG X +MKNK2 Mnk2 Q9HBH9 human SPRY2 10253 O43597 SPRY2 human S121 465676 VssGsRSsTRtSTSs X +Syk Syk P48025 mouse Syk 20963 P48025 Syk mouse Y317 447658 STVSFNPyEPtGGPW X 2715 +Syk Syk P48025 mouse Syk 20963 P48025 Syk mouse Y342 447659 LPMDTEVyESPyADP X +Syk Syk P48025 mouse PKCB 18751 P68404 Prkcb mouse Y662 455926 NEFAGFsyTNPEFVI Pkinase_C X X +Syk Syk P48025 mouse HPK1 26411 P70218 Map4k1 mouse Y379 448160 LsDsDDDyDDVDIPA X +Syk Syk P48025 mouse Ikaros 22778 Q03267 Ikzf1 mouse S357 14160239 PsDGPPRsNHsAQDA X +Syk Syk P48025 mouse SH3BP2 24055 Q06649 Sh3bp2 mouse Y183 449092 HEDEDDSyLEPDSPG X +Syk Syk P48025 mouse SH3BP2 24055 Q06649 Sh3bp2 mouse Y174 449091 YPMDNEDyEHEDEDD X +Syk Syk P48025 mouse PKCA 18750 P20444 Prkca mouse Y658 455927 sDFEGFsyVNPQFVH Pkinase_C X X +Syk Syk P48025 mouse SH3BP2 24055 Q06649 Sh3bp2 mouse Y446 449093 EEDsDEDyEKVPLPN X +Syk Syk P48025 mouse Syk 20963 P48025 Syk mouse Y130 447657 KENLIREyVKQTWNL X X +Syk Syk P48025 mouse SWAP-70 20947 Q6A028 Swap70 mouse Y517 450716 RKQALEQyEGVKKKL X X +Syk Syk P48025 mouse Ikaros 22778 Q03267 Ikzf1 mouse S360 4714822 GPPRsNHsAQDAVDN X +Syk Syk P48025 mouse Syk 20963 P48025 Syk mouse Y519 447661 ALRADENyyKAQTHG PK_Tyr_Ser-Thr X 2711; 2710; 12967; 5514; 4349; 6485; 12081; 46994; 16859 +Syk Syk P48025 mouse Syk 20963 P48025 Syk mouse Y520 447662 LRADENyyKAQTHGK PK_Tyr_Ser-Thr X 2711; 2710; 12967; 5514; 4349; 6485; 12081; 46994; 16859 +Syk Syk P48025 mouse PYCARD 66824 Q9EPB4 Pycard mouse Y144 465096 SVLTEGQyQAVRAET CARD X +Syk Syk P48025 mouse CEACAM20 71601 Q9D2Z1 Ceacam20 mouse Y559 41604100 GRNEESNyEKLLNSN X +Syk Syk P48025 mouse Syk 20963 P48025 Syk mouse Y346 447660 TEVyESPyADPEEIR X 2701; 2717; 14791; 73382; 82975; 31754 +Syk Syk P48025 mouse CEACAM20 71601 Q9D2Z1 Ceacam20 mouse Y570 41604101 LNSNHSLyCKITPSA X +PIM3 Pim3 Q86V86 human LDH-A 3939 P00338 LDHA human S161 31882218 PkNrVIGsGCNLDsA X X +PIM3 Pim3 Q86V86 human STAT5B 6777 P51692 STAT5B human S731 448751 TyMDQAPsPAVCPQA X +PIM3 Pim3 Q86V86 human BAD 12015 Q61337 Bad mouse S112 447860 ETRsRHssyPAGtEE Bcl-2_BAD X 9291; 5284; 9296; 5193; 11865; 94223 +PIM3 Pim3 Q86V86 human Myc 4609 P01106 MYC human S308 10852562 GHskPPHsPLVLkrC Myc_N X +PIM3 Pim3 Q86V86 human LDH-A 3939 P00338 LDHA human S319 24986816 EEARLkksADtLWGI Ldh_1_C X +PIM3 Pim3 Q86V86 human BAD 12015 Q61337 Bad mouse S155 447863 GRELRRMsDEFEGsF Bcl-2_BAD X 9297 +PIM3 Pim3 Q86V86 human BAD 572 Q92934 BAD human S75 447860 EIRsRHssyPAGtED Bcl-2_BAD X 9291; 5284; 9296; 5193; 11865; 94223 +PIM3 Pim3 Q86V86 human IRS1 3667 P35568 IRS1 human S1101 453434 GCRRRHssEtFsStP X +PIM3 Pim3 Q86V86 human Notch 1 18128 Q01705 Notch1 mouse S2152 3252805 GkkARkPsTkGLACG X +PIM3 Pim3 Q86V86 human PSMD2 5708 Q13200 PSMD2 human S361 487471 ENNrFGGsGsQVDsA X X +PIM3 Pim3 Q86V86 human BAD 12015 Q61337 Bad mouse S136 447862 PFRGRsRsAPPNLWA Bcl-2_BAD X 9295; 5286; 4366 +LCK Lck P06239 human PRDX1 5052 Q06830 PRDX1 human Y194 448924 DVQkSkEyFskQK__ 1-cysPrx_C X 14041 +LCK Lck P06239 human Syk 20963 P48025 Syk mouse Y317 447658 STVSFNPyEPtGGPW X 2715 +LCK Lck P06239 human CD5 921 P06127 CD5 human Y453 447774 AsHVDNEysQPPRNs X X +LCK Lck P06239 human PLCG2 5336 P16885 PLCG2 human Y753 447940 ERDINSLyDVsRMyV X +LCK Lck P06239 human IL2RB 3560 P14784 IL2RB human Y418 450884 LSGEDDAyCTFPSRD X +LCK Lck P06239 human CD3Z 919 P20963 CD247 human Y142 448932 GkGHDGLyQGLstAt ITAM X 67748 +LCK Lck P06239 human ARHGAP3 1124 P52757 CHN2 human Y153 473503 KMTTNPIyEHIGyAt X +LCK Lck P06239 human ZAP70 7535 P43403 ZAP70 human Y315 448867 MPMDtsVyEsPysDP X +LCK Lck P06239 human CD163L1 338056 P30205 CD163L1 cow Y1326 470034 DALAEAVyEELDYLL X +LCK Lck P06239 human LKB1 20869 Q9WTK7 Stk11 mouse Y365 13258701 DIEDGIIytQDFTVP X +LCK Lck P06239 human SHP-1 5777 P29350 PTPN6 human Y564 448912 sKHkEDVyENLHTkN X X 8849 +LCK Lck P06239 human SHC1 iso2 6464 P29353-2 SHC1 human Y239 448509 EEPPDHQyyNDFPGK X +LCK Lck P06239 human VAV1 7409 P15498 VAV1 human Y142 448809 SVGDEDIySGLSDQI X +LCK Lck P06239 human ZAP70 7535 P43403 ZAP70 human Y474 455368 VLLVNRHyAkISDFG PK_Tyr_Ser-Thr X +LCK Lck P06239 human STAP2 55620 Q9UGK3 STAP2 human Y250 478353 PFLLDEDyEKVLGyV X +LCK Lck P06239 human IL2RB 3560 P14784 IL2RB human Y384 450882 ACQVyFTyDPySEED X +LCK Lck P06239 human TSAd 9047 Q9NP31 SH2D2A human Y280 449440 PKPSNPIyNEPDEPI X +LCK Lck P06239 human VAV1 7409 P15498 VAV1 human Y174 447866 EAEGDEIyEDLMRsE X +LCK Lck P06239 human PIK3R1 282307 P23727 PIK3R1 cow Y368 448134 STKMHGDyTLTLRKG SH2 X +LCK Lck P06239 human BTLA 151888 Q7Z6A9 BTLA human Y257 454099 ENKPGIVyASLNHsV X +LCK Lck P06239 human STAT2 6773 P52630 STAT2 human Y690 448193 NLQERRKyLKHRLIV X 4441; 88410; 77366; 68826; 90740; 23078 +LCK Lck P06239 human CD28 12487 P31041 Cd28 mouse Y207 450284 TRKPYQPyAPARDFA X +LCK Lck P06239 human STAT5A 6776 P42229 STAT5A human Y694 447767 LAkAVDGyVkPQIkQ X 9365; 9356; 9359; 9351; 4322; 9314; 3939; 40284; 5387; 14603; 66740; 51879; 72712 +LCK Lck P06239 human ZAP70 22637 P43404 Zap70 mouse Y318 447587 TSVyESPySDPEELK X 2701; 2717; 14791; 73382; 82975; 31754 +LCK Lck P06239 human SLAM 6504 Q13291 SLAMF1 human Y307 448264 QDPCTTIyVAATEPV X +LCK Lck P06239 human ADAM15 8751 Q13444 ADAM15 human Y715 451223 LVMLGASyWYRARLH TM X +LCK Lck P06239 human LNK 16923 O09039 Sh2b3 mouse Y536 476934 LRAIDNQyTPLSQLC X +LCK Lck P06239 human PLCG2 5336 P16885 PLCG2 human Y1197 447938 LESEEELySSCRQLR X +LCK Lck P06239 human ITGB2 3689 P05107 ITGB2 human Y735 26400600 HLSDLREyRRFEkEK Integrin_b_cyt X +LCK Lck P06239 human ZAP70 7535 P43403 ZAP70 human Y319 447587 tsVyEsPysDPEELk X X 2701; 2717; 14791; 73382; 82975; 31754 +LCK Lck P06239 human VAV1 22324 P27870 Vav1 mouse Y160 447865 AEEDEDLyDCVENEE X +LCK Lck P06239 human DGKA 1606 P23743 DGKA human Y335 486452 ILPPSSIyPSVLASG X X +LCK Lck P06239 human CD3Z 12503 P24161 Cd247 mouse Y123 448934 KDKMAEAysEIGTKG ITAM X +LCK Lck P06239 human SHC1 iso2 6464 P29353-2 SHC1 human Y240 448510 EPPDHQyyNDFPGKE X +LCK Lck P06239 human TSAd 9047 Q9NP31 SH2D2A human Y305 450668 GEAPsNIyVEVEDEG X +LCK Lck P06239 human LKB1 20869 Q9WTK7 Stk11 mouse Y261 13258700 PFEGDNIyKLFENIG Pkinase X +LCK Lck P06239 human PTEN 5728 P60484 PTEN human Y240 448316 RREDKFMyFEFPQPL PTEN_C2 X +LCK Lck P06239 human SOCS3 9021 O14543 SOCS3 human Y221 450447 IREFLDQyDAPL___ X +LCK Lck P06239 human PPP2CA 5515 P67775 PPP2CA human Y307 448571 VTRRtPDyFl_____ X +LCK Lck P06239 human Siglec-10 89790 Q96LC7 SIGLEC10 human Y597 450086 RHstILDyINVVPTA X +LCK Lck P06239 human TSAd 9047 Q9NP31 SH2D2A human Y260 480756 PQLPPEVytIPVPRH X +LCK Lck P06239 human Syk 20963 P48025 Syk mouse Y342 447659 LPMDTEVyESPyADP X +LCK Lck P06239 human IL2RB 3560 P14784 IL2RB human Y381 450881 EIEACQVyFTyDPyS X +LCK Lck P06239 human THEMIS 387357 Q8N1K5 THEMIS human Y429 27806312 EAALLPLyMEGGFVE CABIT X +LCK Lck P06239 human CBL 867 P22681 CBL human Y774 448531 sENEDDGyDVPKPPV X 3555 +LCK Lck P06239 human THEMIS 387357 Q8N1K5 THEMIS human Y540 27806313 EEITEEQyyMMRRYE X X +LCK Lck P06239 human LAX1 54900 Q8IWV1 LAX1 human Y373 460158 SNEDSSDyENVLTAK LAX X +LCK Lck P06239 human ITK 3702 Q08881 ITK human Y512 447997 RFVLDDQytsstGtk PK_Tyr_Ser-Thr X X +LCK Lck P06239 human TBK1 29110 Q9UHD2 TBK1 human Y354 3437786 SSNQELIyEGRRLVL TBK1_ULD X +LCK Lck P06239 human Lck 3932 P06239 LCK human Y394 447822 RLIEDNEytAREGAk PK_Tyr_Ser-Thr X X 2101; 6943; 59548; 70926; 78740; 94361; 17320 +LCK Lck P06239 human CD3Z 12503 P24161 Cd247 mouse Y72 448936 LQDPNQLyNELNLGR ITAM X +LCK Lck P06239 human ZAP70 7535 P43403 ZAP70 human Y69 447588 ERQLNGTyAIAGGkA SH2 X +LCK Lck P06239 human THEMIS 387357 Q8N1K5 THEMIS human Y95 27806315 IVADkTPyLTMEEIT CABIT X +LCK Lck P06239 human SLP76 3937 Q13094 LCP2 human Y128 448219 DGEDDGDyEsPNEEE X +LCK Lck P06239 human SLC25A4 291 P12235 SLC25A4 human Y195 457913 RAAyFGVyDtAkGML TM; Mito_carr X +LCK Lck P06239 human LAX1 54900 Q8IWV1 LAX1 human Y193 35546000 SSEDSHDyVNVPTAE LAX X +LCK Lck P06239 human CD3Z 12503 P24161 Cd247 mouse Y142 448932 GKGHDGLyQGLsTAT ITAM X X +LCK Lck P06239 human TSAd 9047 Q9NP31 SH2D2A human Y290 449441 PDEPIAFyAMGrGsP X +LCK Lck P06239 human MED28 80306 Q9H204 MED28 human Y64 466940 ASLVSQDyVNGTDQE Med28 X X +LCK Lck P06239 human SHC1 iso2 6464 P29353-2 SHC1 human Y317 448511 ELFDDPSyVNVQNLD X +LCK Lck P06239 human SSBP3 23648 Q9BWW4 SSBP3 human Y25 1806901 EkLALyVyEYLLHVG X +LCK Lck P06239 human VAV1 22324 P27870 Vav1 mouse Y142 448809 ALNDEDIySGLSDQI X +LCK Lck P06239 human CD33 945 P20138 CD33 human Y340 450952 EMDEELHyASLNFHG X +LCK Lck P06239 human CCDC50 152137 Q8IVM0 CCDC50 human Y304 6377636 SSHkGFHyKH_____ X +LCK Lck P06239 human ZAP70 7535 P43403 ZAP70 human Y493 447505 LGADDsyytARsAGk PK_Tyr_Ser-Thr X X 2704 +LCK Lck P06239 human Lck 3932 P06239 LCK human Y505 447823 FTAtEGQyQPQP___ X X 2751; 37458 +LCK Lck P06239 human LAX1 54900 Q8IWV1 LAX1 human Y268 35546002 SSQISNDyVNMTGLD LAX X +LCK Lck P06239 human VAV1 7409 P15498 VAV1 human Y160 447865 VEEDEDLyDCVENEE X +LCK Lck P06239 human IL2RB 3560 P14784 IL2RB human Y536 450934 LPLNTDAyLSLQELQ X +LCK Lck P06239 human PLCG2 5336 P16885 PLCG2 human Y759 447941 LyDVsRMyVDPsEIN X 3874; 50535 +LCK Lck P06239 human SLP76 3937 Q13094 LCP2 human Y145 448220 PVEDDADyEPPPSND X 14770; 16796 +LCK Lck P06239 human ZAP70 7535 P43403 ZAP70 human Y178 447590 EEAERkLysGAQTDG SH2 X +LCK Lck P06239 human BTLA 151888 Q7Z6A9 BTLA human Y226 1869334004 LLSETGIyDNDPDLC X +LCK Lck P06239 human PECAM-1 5175 P16284 PECAM1 human Y713 448760 KKDtEtVysEVRKAV X +LCK Lck P06239 human SSBP3 23648 Q9BWW4 SSBP3 human Y23 1806900 AREkLALyVyEYLLH X +LCK Lck P06239 human CD3Z 12503 P24161 Cd247 mouse Y153 455204 sTATKDtyDALHMQT ITAM X +LCK Lck P06239 human KSR 16706 Q61097 Ksr1 mouse Y728 3428057 LSHDWLCyLAPEIVR PK_Tyr_Ser-Thr X +LCK Lck P06239 human THEMIS 387357 Q8N1K5 THEMIS human Y541 27806310 EITEEQyyMMRRYES X X +LCK Lck P06239 human P38A 1432 Q16539 MAPK14 human Y323 455799 DEPVADPyDQsFESR X +LCK Lck P06239 human PIK3R1 282307 P23727 PIK3R1 cow Y688 448137 FAEPYNLySSLKELV SH2 X +LCK Lck P06239 human ZAP70 7535 P43403 ZAP70 human Y492 447504 ALGADDsyytARsAG PK_Tyr_Ser-Thr X X +LCK Lck P06239 human SHP-1 5777 P29350 PTPN6 human Y536 448506 QkGQEsEyGNItyPP X +LCK Lck P06239 human IL2RB 3560 P14784 IL2RB human Y387 450883 VyFTyDPySEEDPDE X +LCK Lck P06239 human CD3Z 12503 P24161 Cd247 mouse Y83 449322 NLGRREEyDVLEKKR ITAM X +LCK Lck P06239 human CBL 867 P22681 CBL human Y700 448529 EGEEDtEyMtPssRP X 8869 +LCK Lck P06239 human PTEN 5728 P60484 PTEN human Y315 448317 RADNDKEyLVLtLtK PTEN_C2 X +LCK Lck P06239 human PKCT 5588 Q04759 PRKCQ human Y90 448588 SETTVELySLAERCR X X +LCK Lck P06239 human SENP1 29843 Q9P0U3 SENP1 human Y270 1876335002 EQLSHSVySLSSYTP X +LCK Lck P06239 human CD5 921 P06127 CD5 human Y487 447775 DNssDsDyDLHGAQR X X +LCK Lck P06239 human DLG1 13383 Q811D0 Dlg1 mouse Y222 35530400 GTDADYEyEEITLER MAGUK_N_PEST X +LCK Lck P06239 human ACP1 52 P24666 ACP1 human Y132 450718 QLIIEDPyyGNDsDF LMWPc X +LCK Lck P06239 human ER-alpha 2099 P03372 ESR1 human Y537 448103 CKNVVPLyDLLLEML X +LCK Lck P06239 human SPTAN1 64159 P16086 Sptan1 rat Y1176 448817 AVQQQEVyGMMPRDE X +LCK Lck P06239 human Siglec-10 89790 Q96LC7 SIGLEC10 human Y667 450087 ESQEELHyATLNFPG X +LCK Lck P06239 human TIGIT 201633 Q495A1 TIGIT human Y225 27266400 DCAELHDyFNVLSYR X +LCK Lck P06239 human THEMIS 387357 Q8N1K5 THEMIS human Y174 27806311 LsQEGEFyECEDERI CABIT X +LCK Lck P06239 human IkB-alpha 4792 P25963 NFKBIA human Y42 448737 DsMkDEEyEQMVkEL X X +LCK Lck P06239 human BTLA 151888 Q7Z6A9 BTLA human Y282 463077 VKEAPtEyASICVRS X +LCK Lck P06239 human CD28 12487 P31041 Cd28 mouse Y189 450282 NRLLQSDyMNMTPRR X 16399 +LCK Lck P06239 human TRPM8 171384 Q8R455 Trpm8 rat Y1022 1877492902 FVVFAYFyMVVKKCF X X +LCK Lck P06239 human G3BP-1 10146 Q13283 G3BP1 human Y56 454080 GkPADAVyGQkEIHR NTF2 X X +LCK Lck P06239 human CCDC50 152137 Q8IVM0 CCDC50 human Y279 462101 tDGEDADytHFtNQQ X +LCK Lck P06239 human BTLA 151888 Q7Z6A9 BTLA human Y243 1869334003 MQEGSEVySNPCLEE X +LCK Lck P06239 human LAX1 54900 Q8IWV1 LAX1 human Y294 35546001 AFQCCRDyENVPAAD LAX X +LCK Lck P06239 human CCDC50 152137 Q8IVM0 CCDC50 human Y217 6377637 MAEEkKAykkAkERE X +LCK Lck P06239 human SOCS3 9021 O14543 SOCS3 human Y204 450446 VNGHLDSyEkVTQLP X +LCK Lck P06239 human CBL 867 P22681 CBL human Y731 448530 QQIDSCTyEAMyNIQ X 3554 +LCK Lck P06239 human ZAP70 7535 P43403 ZAP70 human Y126 447589 RDAMVRDyVRQTWkL X +LCK Lck P06239 human ZAP70 7535 P43403 ZAP70 human Y292 447586 DtLNsDGytPEPARI X +LCK Lck P06239 human Ezrin 7430 P15311 EZR human Y146 448758 kEVHksGyLSsERLI FERM_M X +LCK Lck P06239 human Siglec-10 89790 Q96LC7 SIGLEC10 human Y691 450088 PKGTQADyAEVKFQ_ X +LCK Lck P06239 human WASP 7454 P42768 WAS human Y291 447985 AEtsKLIyDFIEDQG PBD X +LCK Lck P06239 human SLP76 3937 Q13094 LCP2 human Y113 448218 ssFEEDDyESPNDDQ X +LCK Lck P06239 human Lck 16818 P06240 Lck mouse Y394 447822 RLIEDNEytAREGAK PK_Tyr_Ser-Thr X 2101; 6943; 59548; 70926; 78740; 94361; 17320 +LCK Lck P06239 human LKB1 20869 Q9WTK7 Stk11 mouse Y36 14575494 IDstEVIyQPRRKRA X +LCK Lck P06239 human CD3Z 12503 P24161 Cd247 mouse Y111 448933 RNPQEGVyNALQKDK ITAM X +LCK Lck P06239 human Syk 20963 P48025 Syk mouse Y346 447660 TEVyESPyADPEEIR X X 2701; 2717; 14791; 73382; 82975; 31754 +LCK Lck P06239 human ACP1 52 P24666 ACP1 human Y133 457445 LIIEDPyyGNDsDFE LMWPc X +LCK Lck P06239 human TBK1 29110 Q9UHD2 TBK1 human Y394 126839800 LNTIGLIyEkISLPk TBK1_ULD X +LCK Lck P06239 human THEMIS 387357 Q8N1K5 THEMIS human Y353 27806314 PREFPTAyDLEIAkS CABIT X +LCK Lck P06239 human DAPP1 27071 Q9UN19 DAPP1 human Y139 448325 kVEEPsIyEsVRVHT X X 13703 +LCK Lck P06239 human VAV1 22324 P27870 Vav1 mouse Y174 447866 EAEGDEIyEDLMRLE X +LCK Lck P06239 human PLCG2 5336 P16885 PLCG2 human Y1217 447939 LNNQLFLyDtHQNLR X 3871 +LCK Lck P06239 human FOXP3 50943 Q9BZS1 FOXP3 human Y342 29606712 NMRPPFTyATLIRWA Forkhead X X +EPHA1 EphA1 P21709 human GJB1 2705 P08034 GJB1 human Y243 3559630 GHRLsPEyKQNEINk X X +MST1R Ron Q04912 human Abl 25 P00519 ABL1 human Y393 450298 RLMtGDtytAHAGAk PK_Tyr_Ser-Thr X 2865 +MST1R Ron Q04912 human Met 4233 P08581 MET human Y1349 448472 stFIGEHyVHVNAty X 3133; 3121 +MST1R Ron Q04912 human Abl 25 P00519 ABL1 human Y226 450303 KRNKPtVyGVsPNyD X 2868; 2861 +MST1R Ron Q04912 human GJB1 2705 P08034 GJB1 human Y243 3559630 GHRLsPEyKQNEINk X +MST1R Ron Q04912 human Met 4233 P08581 MET human Y1356 448473 yVHVNAtyVNVKCVA X +MST1R Ron Q04912 human Met 4233 P08581 MET human Y1234 448470 RDMyDkEyysVHNkt PK_Tyr_Ser-Thr X 4091; 3129; 3126; 3077; 12468; 4033; 98954 +MST1R Ron Q04912 human Met 4233 P08581 MET human Y1235 448471 DMyDkEyysVHNktG PK_Tyr_Ser-Thr X 4091; 3129; 3126; 3077; 12468; 4033; 98954 +Prkaa2 AMPKA2 Q8BRK8 mouse beclin 1 56208 O88597 Becn1 mouse S91 5473540 ARMMsTEsANsFTLI X 14717 +Prkaa2 AMPKA2 Q8BRK8 mouse AP-2 alpha 21418 P34056 Tfap2a mouse S219 25581601 CSVPGRLsLLSSTSK TF_AP-2 X +Prkaa2 AMPKA2 Q8BRK8 mouse IKKB 16150 O88351 Ikbkb mouse S181 447489 DQGsLCTsFVGTLQy Pkinase X 2697; 2694; 14938; 92255; 36516; 36214 +Prkaa2 AMPKA2 Q8BRK8 mouse ACC1 107476 Q5SWU9 Acaca mouse S79 448292 FHMRSsMsGLHLVKQ X 3661; 11818; 42801 +Prkaa2 AMPKA2 Q8BRK8 mouse TBC1D17 233204 Q8BYH7 Tbc1d17 mouse S168 1873559800 RALLRVLsRYLLLAS PH_RBD X +Prkaa2 AMPKA2 Q8BRK8 mouse ACE2 70008 Q8R0I0 Ace2 mouse S680 1868162500 SDLKPRVsFYFFVTS Collectrin X +Prkaa2 AMPKA2 Q8BRK8 mouse IKKB 16150 O88351 Ikbkb mouse S177 447492 AKELDQGsLCTsFVG Pkinase X 2078; 2697; 2694; 14938; 92255; 36516; 36214 +Prkaa2 AMPKA2 Q8BRK8 mouse ULK1 22241 O70405 Ulk1 mouse S555 3176155 GLGCRLHsAPNLSDF X 5869 +Prkaa2 AMPKA2 Q8BRK8 mouse p53 22059 P02340 Tp53 mouse S18 447490 IsLELPLsQEtFsGL P53_TAD X 9284; 9286; 12571; 56979 +Prkaa2 AMPKA2 Q8BRK8 mouse PD-L1 29126 Q9NZQ7 CD274 human S283 14735979 DTNsKkQsDtHLEEt X +Prkaa2 AMPKA2 Q8BRK8 mouse GFAT 14583 P47856 Gfpt1 mouse S259 467935 CGLsRVDsttCLFPV X X +Prkaa2 AMPKA2 Q8BRK8 mouse AS160 210789 Q8BYJ6 Tbc1d4 mouse S711 2226513 PSLHTSFsAPSFTAP X +Stk24 MST3 Q99KH8 mouse RHOA 11848 Q9QUI0 Rhoa mouse S26 484601 tCLLIVFsKDQFPEV Ras X +RET Ret iso3 Q15300 human STAT3 6774 P40763 STAT3 human Y705 448192 DPGsAAPyLktKFIC X 4093; 9145; 4324; 9131; 9138; 4323; 4074; 4113; 48313; 20977; 25023; 8119; 52075; 52527; 73533; 61958; 73452; 16185; 74309 +RET Ret iso3 Q15300 human Ret iso3 5979 Q15300 RET human Y586 447625 TWIENKLyGRISHAF X +Prkab1 AMPKB1 Q9R078 mouse STIM1 20866 P70302 Stim1 mouse S257 468872 GLHRAEQsLHDLQER X +Prkab1 AMPKB1 Q9R078 mouse STIM1 20866 P70302 Stim1 mouse S521 468874 rDLtHsDsEssLHMs X +UHMK1 KIS Q8TAS1 human FAM64A 54478 Q9BSJ6 PIMREG human S131 14573437 GAQKGsGsPtHsLsQ RCS1 X X +UHMK1 KIS Q8TAS1 human STMN1 3925 P16949 STMN1 human S38 448556 sVPEFPLsPPkKkDL Stathmin X 3426; 4191 +UHMK1 KIS Q8TAS1 human SRC-3 8202 Q9Y6Q9 NCOA3 human S1062 4252805 DQLHtLLsNtDAtGL Nuc_rec_co-act X X +UHMK1 KIS Q8TAS1 human SF1 7536 Q15637 SF1 human S80 452434 PPNPEDRsPsPEPIy SF1-HH X X +UHMK1 KIS Q8TAS1 human p27Kip1 1027 P46527 CDKN1B human S10 447874 NVRVSNGsPsLErMD X X +UHMK1 KIS Q8TAS1 human SRC-3 8202 Q9Y6Q9 NCOA3 human T1067 4252800 LLsNtDAtGLEEIDR Nuc_rec_co-act X X +UHMK1 KIS Q8TAS1 human SF1 7536 Q15637 SF1 human S82 452435 NPEDRsPsPEPIyNs SF1-HH X X +Mst1r Ron Q62190 mouse Ron 19882 Q62190 Mst1r mouse Y1294 456484 EYCPDSLyHVMLRCW PK_Tyr_Ser-Thr X +Mst1r Ron Q62190 mouse Ron 19882 Q62190 Mst1r mouse Y1265 456483 LTRGAPPyPHIDPFD PK_Tyr_Ser-Thr X +Mst1r Ron Q62190 mouse Ron 19882 Q62190 Mst1r mouse Y1175 456482 QVACGMEyLAEQKFV PK_Tyr_Ser-Thr X +PHKG1 PHKG1 Q16816 human GAP43 281777 P06836 GAP43 cow S41 448719 AATKIQAsFRGHITR IQ X +PHKG1 PHKG1 Q16816 human neurogranin 616955 P35722 NRGN cow S36 455913 AAAKIQAsFRGHMAR IQ X +Prkg2 PKG2 Q64595 rat PLCB3 29322 Q99JE6 Plcb3 rat S1105 448448 LDRKRNNsISEAKTR PLC-beta_C X X 2484 +Prkg2 PKG2 Q64595 rat PKG2 25523 Q64595 Prkg2 rat S110 450474 LDVHRKTsGLVsLHs X +Prkg2 PKG2 Q64595 rat PKG2 25523 Q64595 Prkg2 rat S445 450476 KEKVARFsSTSPFQN X +Prkg2 PKG2 Q64595 rat PKG2 25523 Q64595 Prkg2 rat S114 450475 RKTsGLVsLHsRRGA X +Prkg2 PKG2 Q64595 rat PLCB3 29322 Q99JE6 Plcb3 rat S26 448449 VETLRRGsKFIKWDE PH_14 X X +Cdk9 CDK9 Q641Z4 rat POLR2A 363633 D4A5A6 Polr2a rat S1616 450204 TPQSPSYsPTsPSYS RNA_pol_Rpb1_R X 4735; 13499; 13546; 31262 +Ulk1 ULK1 O70405 mouse beclin 1 56208 O88597 Becn1 mouse S14 25268704 SSSTMQVsFVCQRCS X X 84966 +Ulk1 ULK1 O70405 mouse RAB9A 56382 Q9R0M6 Rab9a mouse S179 3191548 ILAtEDRsEHLIQTD X X +Ulk1 ULK1 O70405 mouse FUNDC1 72018 Q9DB70 Fundc1 mouse S17 2025377 DyEsDDEsyEVLDLT X +IKBKE IKKE Q14164 human PELI1 57162 Q96FA3 PELI1 human T80 7388010 DQHsIsYtLsRAQtV Pellino X +IKBKE IKKE Q14164 human NFAT2 4772 O95644 NFATC1 human S324 56629003 NALTTDSsLDLGDGV X +IKBKE IKKE Q14164 human IRF3 3661 Q14653 IRF3 human S386 448684 ARVGGAssLENtVDL X X 37829; 73981; 96421; 91968 +IKBKE IKKE Q14164 human TRAF3IP2 103213 Q8N7N6 Traf3ip2 mouse S222 25687505 DLPGPLRsRELPPQF X X +IKBKE IKKE Q14164 human IRF1 3659 P10914 IRF1 human S219 31839600 FQVsPMPsTsEATTD X X +IKBKE IKKE Q14164 human PELI1 57162 Q96FA3 PELI1 human T288 7388016 QCPVGFNtLAFPsMk Pellino X +IKBKE IKKE Q14164 human IRF7 3665 Q92985 IRF7 human S477 1276101 VssLDSSsLsLCLsS X X 12390 +IKBKE IKKE Q14164 human STAT1 20846 P42225 Stat1 mouse S708 7723201 yIkTELIsVSEVHPS X +IKBKE IKKE Q14164 human Akt1 207 P31749 AKT1 human S473 447855 RPHFPQFsysAsGtA Pkinase_C X X 9271; 3787; 4060; 4051; 5102; 4058; 2336; 2337; 4075; 4070; 5012; 4071; 92982; 5315; 9563; 9018; 12694; 52240; 11962; 15116; 88106; 26580; 68035; 31957; 23430; 20235 +IKBKE IKKE Q14164 human IRF1 3659 P10914 IRF1 human S215 31839602 DLYNFQVsPMPsTsE X X +IKBKE IKKE Q14164 human NFAT2 4772 O95644 NFATC1 human S151 56629000 VLPSSKRsPstATLs X +IKBKE IKKE Q14164 human IRF3 3661 Q14653 IRF3 human S398 449029 VDLHIsNsHPLsLts X +IKBKE IKKE Q14164 human CDK2AP1 8099 O14519 CDK2AP1 human S46 25126700 LSDYGPPsLGYTQGT CDK2AP X +IKBKE IKKE Q14164 human IRF1 3659 P10914 IRF1 human S221 31839601 VsPMPsTsEATTDED X X +IKBKE IKKE Q14164 human YAP1 10413 P46937 YAP1 human S419 31884052 tPDDFLNsVDEMDTG X X +IKBKE IKKE Q14164 human DDX3 1654 O00571 DDX3X human S102 11183059 rFDDrGrsDyDGIGs X X +IKBKE IKKE Q14164 human PBXIP1 57326 Q96AQ6 PBXIP1 human S147 471206 REEGRCsssDDDtDV X +IKBKE IKKE Q14164 human NFkB-p65 5970 Q04206 RELA human S536 447800 sGDEDFSsIADMDFS X X 4887; 3036; 3031; 4886; 3033; 4025; 5733; 13346; 76778; 31553; 80477; 73992; 87672; 83962 +IKBKE IKKE Q14164 human IRF7 3665 Q92985 IRF7 human S479 2868600 sLDSSsLsLCLsSAN X X +IKBKE IKKE Q14164 human NFkB-p65 5970 Q04206 RELA human S468 451145 AVFTDLAsVDNsEFQ X X 3039 +IKBKE IKKE Q14164 human IKKE 9641 Q14164 IKBKE human T501 34434402 ELRSRLRtLAEVLSR TBK1_CCD1 X X +IKBKE IKKE Q14164 human IRF3 3661 Q14653 IRF3 human S402 449030 IsNsHPLsLtsDQYK X X +IKBKE IKKE Q14164 human STAT1 20846 P42225 Stat1 mouse S744 7723202 IVGPEFDsMMsTV__ X +IKBKE IKKE Q14164 human TRAF3IP2 103213 Q8N7N6 Traf3ip2 mouse S209 25687506 ERPLPLTsSCYLQDL X X +IKBKE IKKE Q14164 human IkB-alpha 4792 P25963 NFKBIA human S32 448203 LLDDRHDsGLDsMkD X 5210; 2859; 9246; 5209 +IKBKE IKKE Q14164 human FOXO3A 2309 O43524 FOXO3 human S644 451438 GLDFNFDsLISTQNV FOXO-TAD X X +IKBKE IKKE Q14164 human GSK3A 2931 P49840 GSK3A human S21 448584 sGrARtssFAEPGGG X 9337; 9316; 9331; 5090; 9327; 8452; 8566 +IKBKE IKKE Q14164 human ASB8 140461 Q9H765 ASB8 human S17 1869062300 QSIQSKYsLSERLIR X +IKBKE IKKE Q14164 human IkB-alpha 4792 P25963 NFKBIA human S36 448204 RHDsGLDsMkDEEyE X 5210; 9246 +IKBKE IKKE Q14164 human Snail1 20613 Q02085 Snai1 mouse S165 1876128600 YCNKEYLsLGALKMH zf-C2H2_6 X +IKBKE IKKE Q14164 human Huntingtin 3064 P42858 HTT human S13 10206805 kLMkAFEsLksFQQQ X +IKBKE IKKE Q14164 human IRF3 3661 Q14653 IRF3 human S396 449028 NtVDLHIsNsHPLsL X X 4947; 29047; 83611; 10327; 53539; 81093; 52270; 61166 +IKBKE IKKE Q14164 human TRAF2 7186 Q12933 TRAF2 human S11 5397201 AsVtPPGsLELLQPG X 13908 +IKBKE IKKE Q14164 human IRF7 3665 Q92985 IRF7 human S471 1276102 GTQREGVssLDSSsL X 5184 +IKBKE IKKE Q14164 human RIGI 23586 O95786 RIGI human S855 17484201 PKPkQFssFEkRAKI RIG-I_C-RD X +IKBKE IKKE Q14164 human NFAT2 4772 O95644 NFATC1 human S161 56629001 tATLsLPsLEAYRDP X X +IKBKE IKKE Q14164 human kindlin-2 10979 Q96AC1 FERMT2 human S159 3208605 KkkLDDQsEDEALEL X X +IKBKE IKKE Q14164 human ER-alpha 2099 P03372 ESR1 human S167 448102 GGRERLAsTNDkGSM Oest_recep X X 64508; 42101 +IKBKE IKKE Q14164 human NFAT2 4772 O95644 NFATC1 human S117 56629002 DGAPALEsPRIEITS X +IKBKE IKKE Q14164 human CYLD 74256 Q80TQ2 Cyld mouse S414 4745557 SSENRFHsLPFsLtK CYLD_phos_site X +IKBKE IKKE Q14164 human IRF7 3665 Q92985 IRF7 human S472 1276103 TQREGVssLDSSsLs X 5184 +IKBKE IKKE Q14164 human TRAF3IP2 103213 Q8N7N6 Traf3ip2 mouse S311 21041604 KVILNDSsPQDQEER X +IKBKE IKKE Q14164 human STAT1 20846 P42225 Stat1 mouse S747 7723200 PEFDsMMsTV_____ X +IKBKE IKKE Q14164 human PELI1 57162 Q96FA3 PELI1 human S293 7388014 FNtLAFPsMkRkDVV Pellino X +IKBKE IKKE Q14164 human XIAP 331 P98170 XIAP human S430 22547400 QDESSQtsLQkEIst X X +IKBKE IKKE Q14164 human NFkB-p65 19697 Q04207 Rela mouse S534 447800 sGDEDFssIADMDFS X 4887; 3036; 3031; 4886; 3033; 4025; 5733; 13346; 76778; 31553; 80477; 73992; 87672; 83962 +IKBKE IKKE Q14164 human PELI1 57162 Q96FA3 PELI1 human S76 7388015 IsNKDQHsIsYtLsR Pellino X +IKBKE IKKE Q14164 human STAT2 6773 P52630 STAT2 human T404 1869973803 IWDFGYLtLVEQRSG STAT_bind X X +IKBKE IKKE Q14164 human TRAF3IP2 103213 Q8N7N6 Traf3ip2 mouse S147 25687507 ESDKSDPsLPNALAD X X +IKBKE IKKE Q14164 human Akt1 207 P31749 AKT1 human T308 447856 kDGAtMKtFCGtPEy Pkinase X X 5106; 2965; 9275; 4056; 5056; 13842; 13038; 43506; 48646; 86758; 80722; 77440; 80556 +IKBKE IKKE Q14164 human FAF1 11124 Q9UNN5 FAF1 human S556 27996217 EREAIRLsLEQALPP X X +Btk Btk P35991 mouse Ikaros 22778 Q03267 Ikzf1 mouse S213 28735108 GRSYKQRssLEEHKE zf-C2H2 X +Btk Btk P35991 mouse Btk 12229 P35991 Btk mouse Y551 447486 RYVLDDEyTsSVGSK PK_Tyr_Ser-Thr X 69360; 18805; 64137; 16803 +Btk Btk P35991 mouse Ikaros 22778 Q03267 Ikzf1 mouse S214 28735107 RSYKQRssLEEHKER zf-C2H2 X +Btk Btk P35991 mouse Btk 695 Q06187 BTK human Y223 447485 LKKVVALyDyMPMNA SH3_1 X 5082; 87141; 87457 +Btk Btk P35991 mouse IFNGR2 15980 Q63953 Ifngr2 mouse Y289 1341879204 IPEQIEEyLKDPDQF X X +Btk Btk P35991 mouse STAT5A 20850 P42230 Stat5a mouse Y694 447767 LAKAVDGyVkPQIKQ X 9365; 9356; 9359; 9351; 4322; 9314; 3939; 40284; 5387; 14603; 66740; 51879; 72712 +Btk Btk P35991 mouse Btk 12229 P35991 Btk mouse Y375 457681 GLISRLKyPVSKQNK X +Btk Btk P35991 mouse Btk 12229 P35991 Btk mouse Y617 454022 IAQGLRLyRPHLAsE PK_Tyr_Ser-Thr X + Fyn no information G6PD 2539 P11413 G6PD human Y503 454849 MkRVGFQyEGtykWV G6PD_C X +MAPK12 P38G P53778 human MyoD 4654 P15172 MYOD1 human S201 40684505 SGDSDAssPRsNCsD Myf5 X +MAPK12 P38G P53778 human ATF-2 1386 P15336 ATF2 human T71 448225 IVADQtPtPtRFLkN X 9225; 9221; 5112; 94125; 13850; 40749; 15411; 24329; 61584; 27934; 92109; 20534; 35858 +MAPK12 P38G P53778 human PSD-95 29495 P31016 Dlg4 rat T287 469607 TDyPtAMtPTsPRRY PDZ_assoc X +MAPK12 P38G P53778 human NUP62 23636 P37198 NUP62 human T269 36440512 GAASGTStTTsTAAT X X +MAPK12 P38G P53778 human DLG1 1739 Q12959 DLG1 human S443 5931300 FLGQtPAsPARysPV PDZ_assoc X +MAPK12 P38G P53778 human Tau iso8 4137 P10636-8 MAPT human S396 449081 GAEIVyKsPVVsGDt X 9632 +MAPK12 P38G P53778 human Tau iso8 4137 P10636-8 MAPT human S404 449082 PVVsGDtsPRHLsNV X 35834; 20194; 98523; 91600; 49562 +MAPK12 P38G P53778 human DLG1 1739 Q12959 DLG1 human T209 35547401 VNTDSLEtPTYVNGT MAGUK_N_PEST X +MAPK12 P38G P53778 human STAT2 6773 P52630 STAT2 human Y690 448193 NLQERRKyLKHRLIV X 4441; 88410; 77366; 68826; 90740; 23078 +MAPK12 P38G P53778 human PTPN3 5774 P26045 PTPN3 human S459 25594501 QKSsSSVsPSSNAPG X X +MAPK12 P38G P53778 human HTRA2 27429 O43464 HTRA2 human S142 487466 VPSPPPAsPRSQYNF Peptidase_M50 X +MAPK12 P38G P53778 human HSP90A 3320 P07900 HSP90AA1 human S595 31909111 VsNRLVTsPCCIVts HSP90 X X +MAPK12 P38G P53778 human NUP62 23636 P37198 NUP62 human S272 36440511 SGTStTTsTAATATA X X +MAPK12 P38G P53778 human p53 7157 P04637 TP53 human S33 447531 LPENNVLsPLPsQAM X X 2526 +MAPK12 P38G P53778 human SH3BP5 117186 Q91Y80 Sh3bp5 rat S353 456020 PGSLDLPsPVSLSEF X +MAPK12 P38G P53778 human P38G 6300 P53778 MAPK12 human S3 11380200 _____MSsPPPARSG X +MAPK12 P38G P53778 human SQSTM1 8878 Q13501 SQSTM1 human T269 457004 GGkRsRLtPVsPEss X 13121 +MAPK12 P38G P53778 human SREBP-1 6720 P36956 SREBF1 human S63 23940711 AGGtDPAsPDTSSPG X +MAPK12 P38G P53778 human SREBP-1 6720 P36956 SREBF1 human T426 467200 TEVEDTLtPPPsDAG X +MAPK12 P38G P53778 human CCND3 896 P30281 CCND3 human T283 452160 QGPsQtstPtDVtAI X 53966 +MAPK12 P38G P53778 human DLG1 25252 Q62696 Dlg1 rat T209 35547401 VNTDSLEtPTYVNGT MAGUK_N_PEST X +MAPK12 P38G P53778 human GYS1 2997 P13807 GYS1 human S723 4787599 sssLStPsEPLsPts X +MAPK12 P38G P53778 human HSF1 3297 Q00613 HSF1 human S307 449046 EPPsPPQsPRVEEAs Vert_HS_TF X +MAPK12 P38G P53778 human CTNNB1 1499 P35222 CTNNB1 human S605 3545003 LFVQLLYsPIENIQR Arm X X +MAPK12 P38G P53778 human MyoD 4654 P15172 MYOD1 human S200 452000 YSGDSDAssPRsNCs Myf5 X +MAPK12 P38G P53778 human DLG1 1739 Q12959 DLG1 human S158 2024309 FVsHsHIsPIKPTEA MAGUK_N_PEST X +MAPK12 P38G P53778 human DLG1 25252 Q62696 Dlg1 rat S442 5931300 YLGQTPAsPARYsPI PDZ_assoc X +MAPK12 P38G P53778 human Tau 17762 P10637 Mapt mouse T497 447933 ssPGsPGtPGsRsRt X 25377; 43964; 53001; 49561; 20060; 33032; 30505; 20739; 98160 +MAPK12 P38G P53778 human NALP1 22861 Q9C000 NLRP1 human S107 1880261804 PSEPHLGsPSQPTST X +MAPK12 P38G P53778 human MEF2D 4209 Q14814 MEF2D human S444 449407 SIkSEPVsPsRERsP X +MAPK12 P38G P53778 human HSF1 3297 Q00613 HSF1 human S303 449045 RVkEEPPsPPQsPRV Vert_HS_TF X +MAPK12 P38G P53778 human Tip60 iso2 10524 Q92993-2 KAT5 human T106 10800707 VEVVsPAtPVPSETA X +MAPK12 P38G P53778 human DLG1 25252 Q62696 Dlg1 rat S158 2024309 FVSHSHIsPIKPTEA MAGUK_N_PEST X +MAPK12 P38G P53778 human GYS1 2997 P13807 GYS1 human S727 457615 StPsEPLsPtssLGE X +MAPK12 P38G P53778 human HSF1 3297 Q00613 HSF1 human S326 455484 ssVDtLLsPTALIDs Vert_HS_TF X X +MAPK12 P38G P53778 human GYS1 2997 P13807 GYS1 human T278 1875332700 kRkPDIVtPNGLNVk Glycogen_syn X +MAPK12 P38G P53778 human SQSTM1 8878 Q13501 SQSTM1 human S272 454787 RsRLtPVsPEssstE X 13121 +MAPK12 P38G P53778 human PSD-95 29495 P31016 Dlg4 rat S290 469608 PtAMtPTsPRRYsPV PDZ_assoc X +MAPK12 P38G P53778 human Tip60 10524 Q92993 KAT5 human T158 10800707 VEVVsPAtPVPSETA X +Eif2ak3 PERK Q9Z2B5 mouse PERK 13666 Q9Z2B5 Eif2ak3 mouse T980 447936 MPAYATHtGQVGTKL Pkinase X 3179 +Eif2ak3 PERK Q9Z2B5 mouse eIF2-alpha 13665 Q6ZWX6 Eif2s1 mouse S52 447635 MILLSELsRrrIRSI S1 X 3597; 9721; 3398; 5199; 53085; 95797 +Eif2ak3 PERK Q9Z2B5 mouse eIF2-alpha 1965 P05198 EIF2S1 human S52 447635 MILLsELsRRRIRsI S1 X 3597; 9721; 3398; 5199; 53085; 95797 +MAP2K4 MKK4 P45985 human JNK1 iso2 5599 P45983-2 MAPK8 human Y185 447645 TSFMMtPyVVTRYYR Pkinase X 5136; 9255; 9251; 4306; 5755; 16014 +MAP2K4 MKK4 P45985 human JNK2 5601 P45984 MAPK9 human Y185 447652 tNFMMtPyVVtRYYR Pkinase X X +MAP2K4 MKK4 P45985 human JNK1 5599 P45983 MAPK8 human Y185 447645 tsFMMtPyVVtRYYR Pkinase X X 5136; 4668; 4671; 9257; 9255; 9251; 4306; 5755; 16014; 58328 +MAP2K4 MKK4 P45985 human RXRA 6256 P19793 RXRA human Y249 456812 VEPKTETyVEANMGL X +MAP2K4 MKK4 P45985 human JNK3 5602 P53779 MAPK10 human Y223 448035 tsFMMtPyVVtRYYR Pkinase X 4668; 58328 +MAP2K4 MKK4 P45985 human MKK4 6416 P45985 MAP2K4 human S257 447654 ISGQLVDsIAKtRDA Pkinase X 9156; 4514; 59056; 75450 +MAP2K4 MKK4 P45985 human JNK2 26420 Q9WTU6 Mapk9 mouse T183 447649 ACTNFMMtPyVVtRY Pkinase X +MAP2K4 MKK4 P45985 human JNK1 iso3 5599 P45983-3 MAPK8 human T228 27724402 GGVLFPGtDHIDQWN Pkinase X +MAP2K4 MKK4 P45985 human JNK1 iso3 5599 P45983-3 MAPK8 human S377 454204 GVIRGQPsPLAQVQQ X +MAP2K4 MKK4 P45985 human JNK3 iso2 5602 P53779-2 MAPK10 human Y223 448035 TSFMMtPyVVTRYYR Pkinase X +MAP2K4 MKK4 P45985 human JNK2 26420 Q9WTU6 Mapk9 mouse Y185 447652 TNFMMtPyVVtRYYR Pkinase X +MAP2K4 MKK4 P45985 human JNK1 5599 P45983 MAPK8 human T183 447643 AGtsFMMtPyVVtRY Pkinase X 5136; 4668; 4671; 9257; 9255; 9251; 4306; 5755; 16014; 58328 +MAP2K4 MKK4 P45985 human JNK1 iso3 5599 P45983-3 MAPK8 human T183 447643 AGTSFMMtPyVVTRY Pkinase X +MAP2K4 MKK4 P45985 human P38A 1432 Q16539 MAPK14 human T180 447970 RHtDDEMtGyVAtRW Pkinase X X 9211; 9215; 4551; 9216; 4552; 4631; 4511; 4092; 9219; 24678; 8632; 6908; 41768; 51255; 14594; 14598; 62979 +MAP2K4 MKK4 P45985 human JNK1 iso3 5599 P45983-3 MAPK8 human S284 27724401 DVLFPADsEHNKLKA Pkinase X +MAP2K4 MKK4 P45985 human JNK1 iso3 5599 P45983-3 MAPK8 human Y185 447645 TSFMMtPyVVTRYYR Pkinase X +MAP2K4 MKK4 P45985 human MKK4 6416 P45985 MAP2K4 human T261 447656 LVDsIAKtRDAGCRP Pkinase X 9151; 9156 +MAP2K4 MKK4 P45985 human P38A 1432 Q16539 MAPK14 human Y182 447971 tDDEMtGyVAtRWYR Pkinase X X 9211; 9215; 4551; 9216; 4552; 4631; 4511; 4092; 9219; 24678; 8632; 6908; 41768; 51255; 14594; 14598; 62979 +DCAF1 VPRBP Q9Y4B6 human p53 7157 P04637 TP53 human S367 1881548604 GGsRAHssHLkskkG X X +DCAF1 VPRBP Q9Y4B6 human EZH2 14056 Q61188 Ezh2 mouse T367 466987 NNssRPstPtISVLE X X +DCAF1 VPRBP Q9Y4B6 human H2A.1 8329 P0C0S8 H2AC17 human T120 482914 AVLLPkktEsHHkAk Histone_H2A_C X +CLK4 CLK4 Q9HAZ1 human Abl 25 P00519 ABL1 human T735 450291 DTEWRSVtLPRDLQS X 2864 +CLK4 CLK4 Q9HAZ1 human MITF 4286 O75030 MITF human Y360 50783666 ILKAsVDyIRKLQRE HLH X +CLK4 CLK4 Q9HAZ1 human STF-1 2516 Q13285 NR5A1 human S203 447603 EYPEPYAsPPQPGLP X +PDPK1 PDK1 O15530 human SGK2 iso1 10110 Q9HBY8-1 SGK2 human T253 456159 EPEDTtStFCGtPEY Pkinase X +PDPK1 PDK1 O15530 human PDK1 5170 O15530 PDPK1 human S393 448581 MQVSSSSssHsLsAS X X +PDPK1 PDK1 O15530 human SGK1 29517 Q06226 Sgk1 rat T256 448431 EHNGTTstFCGTPEY Pkinase X +PDPK1 PDK1 O15530 human HIF2A 2034 Q99814 EPAS1 human T324 471073 VWLETQGtVIYNPRN PAS_3 X +PDPK1 PDK1 O15530 human PKCZ 5590 Q05513 PRKCZ human T410 447510 GPGDtTstFCGtPNy Pkinase X 9378; 2060 +PDPK1 PDK1 O15530 human p70S6K 6198 P23443 RPS6KB1 human T412 448607 NQVFLGFtyVAPsVL Pkinase_C X X 9206; 9234; 9205; 9209; 97596 +PDPK1 PDK1 O15530 human RSK2 110651 P18654 Rps6ka3 mouse T577 450152 AENGLLMtPCYtANF Pkinase X +PDPK1 PDK1 O15530 human Akt1 207 P31749 AKT1 human S473 447855 RPHFPQFsysAsGtA Pkinase_C X X 9271; 3787; 4060; 4051; 5102; 4058; 2336; 2337; 4075; 4070; 5012; 4071; 92982; 5315; 9563; 9018; 12694; 52240; 11962; 15116; 88106; 26580; 68035; 31957; 23430; 20235 +PDPK1 PDK1 O15530 human p90RSK 386579 P18652 RPS6KA1 chicken S381 447989 TSRTPKDsPGIPPSA Pkinase_C X X +PDPK1 PDK1 O15530 human PIP5K1C 23396 O60331 PIP5K1C human S448 17550224 NTVFRKNsSLKSsPS X X +PDPK1 PDK1 O15530 human p90RSK 6195 Q15418 RPS6KA1 human S221 447988 DHEKKAysFCGtVEy Pkinase X +PDPK1 PDK1 O15530 human PDK1 5170 O15530 PDPK1 human S410 448583 GLPQRSGsNIEQYIH X X +PDPK1 PDK1 O15530 human MEK1 5604 Q02750 MAP2K1 human S222 448513 LIDsMANsFVGtRSY Pkinase X X 2338; 9121; 3958; 9154; 16211; 86128; 16780; 75262 +PDPK1 PDK1 O15530 human p90RSK 81771 Q63531 Rps6ka1 rat S221 447988 DHEKKAYsFCGTVEY Pkinase X +PDPK1 PDK1 O15530 human Akt3 10000 Q9Y243 AKT3 human T305 448521 tDAAtMKtFCGtPEy Pkinase X 13842; 13038; 86758; 80722; 77440; 80556 +PDPK1 PDK1 O15530 human PDK1 5170 O15530 PDPK1 human S25 448580 VVLCsCPsPSMVRTQ X X +PDPK1 PDK1 O15530 human ASK1 26408 O35099 Map3k5 mouse S973 447736 NEYLRSIsLPVPVLV X 3764 +PDPK1 PDK1 O15530 human SGK1 6446 O00141 SGK1 human T256 448431 EHNSTTStFCGTPEY Pkinase X X +PDPK1 PDK1 O15530 human p70S6K iso2 6198 P23443-2 RPS6KB1 human T229 448606 HDGTVTHtFCGTIEY Pkinase X +PDPK1 PDK1 O15530 human PDK1 5170 O15530 PDPK1 human S396 448582 SSSSssHsLsASDTG X X +PDPK1 PDK1 O15530 human PKCD 170538 P09215 Prkcd rat T505 447511 FGENRAstFCGTPDy Pkinase X X 9379; 9374; 2060; 38938; 93292 +PDPK1 PDK1 O15530 human PGK1 5230 P00558 PGK1 human T243 2525475 IGGGMAFtFLKVLNN PGK X X +PDPK1 PDK1 O15530 human RSK2 110651 P18654 Rps6ka3 mouse S227 448063 DHEKKAysFCGtVEy Pkinase X X 3556 +PDPK1 PDK1 O15530 human PKN1 5585 Q16512 PKN1 human S773 4711320 MGyGDRtstFCGtPE Pkinase X +PDPK1 PDK1 O15530 human PKACA 18747 P05132 Prkaca mouse T198 448459 RVKGRtWtLCGtPEY Pkinase X 4781; 5661 +PDPK1 PDK1 O15530 human PDHA1 5160 P08559 PDHA1 human S293 448258 TYRyHGHsMsDPGVs E1_dh X 31866; 37115; 48447 +PDPK1 PDK1 O15530 human PDK1 5170 O15530 PDPK1 human S241 447693 skQARANsFVGtAQy Pkinase X X 3061; 3438 +PDPK1 PDK1 O15530 human ASK1 26408 O35099 Map3k5 mouse T845 448394 GINPCtEtFTGtLQY Pkinase X 3765 +PDPK1 PDK1 O15530 human Akt2 208 P31751 AKT2 human T309 448537 sDGAtMKtFCGtPEy Pkinase X 13842; 13038; 86758; 80722; 77440; 80556 +PDPK1 PDK1 O15530 human ITGB3 3690 P05106 ITGB3 human T779 470104 LyKEAtstFTNItyR Integrin_b_cyt X +PDPK1 PDK1 O15530 human p70S6K 6198 P23443 RPS6KB1 human S394 448806 TRQtPVDsPDDStLS Pkinase_C X 9208 +PDPK1 PDK1 O15530 human p70S6K 6198 P23443 RPS6KB1 human T252 448606 HDGtVtHtFCGtIEY Pkinase X X +PDPK1 PDK1 O15530 human PKACA 5566 P17612 PRKACA human T198 448459 RVKGRtWtLCGtPEy Pkinase X X 4781; 5661 +PDPK1 PDK1 O15530 human P70S6KB 58988 Q9Z1M4 Rps6kb2 mouse T228 1261114 HEGAItHtFCGTIEY Pkinase X +PDPK1 PDK1 O15530 human PKCZ 25522 P09217 Prkcz rat T410 447510 GPGDTTStFCGTPNY Pkinase X X 9378; 2060 +PDPK1 PDK1 O15530 human PDK1 5170 O15530 PDPK1 human T513 450132 PEAkNFKtFFVHTPN PH_3 X +PDPK1 PDK1 O15530 human SGK3 23678 Q96BR1 SGK3 human T320 448197 AIsDTtTtFCGtPEY Pkinase X X 5642 +PDPK1 PDK1 O15530 human MEK2 5605 P36507 MAP2K2 human S226 448074 LIDsMANsFVGtRSY Pkinase X X 2338; 9121; 3958; 9154; 16211; 86128; 16780; 75262 +PDPK1 PDK1 O15530 human RSK2 110651 P18654 Rps6ka3 mouse S386 448065 HQLFRGFsFVAITSD Pkinase_C X 9341; 9335; 13575; 11989; 12032; 75266; 93317; 13397; 13588 +PDPK1 PDK1 O15530 human PAK1 5058 Q13153 PAK1 human T423 448177 PEQSkRstMVGtPYW Pkinase X 2601 +PDPK1 PDK1 O15530 human PKCD 5580 Q05655 PRKCD human T507 447511 FGEsRAstFCGtPDy Pkinase X X 9379; 9374; 2060; 38938; 93292 +PDPK1 PDK1 O15530 human Akt1 11651 P31750 Akt1 mouse T308 447856 KDGAtMKtFCGtPEy Pkinase X X 5106; 2965; 9275; 4056; 5056; 13842; 13038; 43506; 48646; 86758; 80722; 77440; 80556 +PDPK1 PDK1 O15530 human TSSK3 58864 Q9D2E1 Tssk3 mouse T168 458324 SRRELsQtFCGSTAY Pkinase X +PDPK1 PDK1 O15530 human PDHA1 18597 P35486 Pdha1 mouse S232 448257 NRyGMGtsVERAAAS E1_dh X +PDPK1 PDK1 O15530 human ASK1 4217 Q99683 MAP3K5 human S966 447736 NEYLRsIsLPVPVLV X 3764 +PDPK1 PDK1 O15530 human PKN1 5585 Q16512 PKN1 human T774 447835 GyGDRtstFCGtPEF Pkinase X X 2611 +PDPK1 PDK1 O15530 human Akt1 207 P31749 AKT1 human T308 447856 kDGAtMKtFCGtPEy Pkinase X X 5106; 2965; 9275; 4056; 5056; 13842; 13038; 43506; 48646; 86758; 80722; 77440; 80556 +PDPK1 PDK1 O15530 human PKN2 5586 Q16513 PKN2 human T816 447838 GyGDRtstFCGtPEF Pkinase X 2611 +PDPK1 PDK1 O15530 human PKCB 5579 P05771 PRKCB human T500 447896 WDGVttktFCGtPDy Pkinase X 9379; 2060; 38938 +PDPK1 PDK1 O15530 human PKCE 5581 Q02156 PRKCE human T566 448787 LNGVTTTtFCGTPDy Pkinase X X 9379; 2060; 38938 +MAP3K5 ASK1 Q99683 human SIAH1 6477 Q8IUQ4 SIAH1 human T74 36694103 PKLtCCPtCRGPLGS X X +MAP3K5 ASK1 Q99683 human ASK1 4217 Q99683 MAP3K5 human T838 448394 GINPCTEtFTGtLQY Pkinase X 3765 +MAP3K5 ASK1 Q99683 human STRAP 11171 Q9Y3F4 STRAP human T175 11267002 LWDHAtMtEVKsLNF X +MAP3K5 ASK1 Q99683 human SIAH1 6477 Q8IUQ4 SIAH1 human T239 36694105 RRLtWEAtPRSIHEG Sina X X +MAP3K5 ASK1 Q99683 human SIAH1 6477 Q8IUQ4 SIAH1 human T70 36694104 SNCRPKLtCCPtCRG X X +MAP3K5 ASK1 Q99683 human JNK1 5599 P45983 MAPK8 human Y185 447645 tsFMMtPyVVtRYYR Pkinase X 5136; 4668; 4671; 9257; 9255; 9251; 4306; 5755; 16014; 58328 +MAP3K5 ASK1 Q99683 human ASK1 4217 Q99683 MAP3K5 human T842 450004 CTEtFTGtLQYMAPE Pkinase X +MAP3K5 ASK1 Q99683 human ZNF622 90441 Q969S3 ZNF622 human S314 20765001 WCNEkGksFYStEAV zf-C2H2_2 X X +MAP3K5 ASK1 Q99683 human EB1 22919 Q15691 MAPRE1 human S40 59049801 TKIEQLCsGAAYCQF CH X X +MAP3K5 ASK1 Q99683 human PDK1 5170 O15530 PDPK1 human S398 12729601 SSssHsLsASDTGLP X +MAP3K5 ASK1 Q99683 human p21Cip1 1026 P38936 CDKN1A human S98 478193 GGRRPGTsPALLQGT X X +MAP3K5 ASK1 Q99683 human SIAH1 6477 Q8IUQ4 SIAH1 human T235 36694106 NGHRRRLtWEAtPRS Sina X X +MAP3K5 ASK1 Q99683 human DAXX 1616 Q9UER7 DAXX human S176 3214944 TNAENTAsQsPRTRG X X +MAP3K5 ASK1 Q99683 human MKK3 5606 P46734 MAP2K3 human S218 448276 IsGyLVDsVAKtMDA Pkinase X 9231; 9236; 12280 +MAP3K5 ASK1 Q99683 human JNK1 5599 P45983 MAPK8 human T183 447643 AGtsFMMtPyVVtRY Pkinase X 5136; 4668; 4671; 9257; 9255; 9251; 4306; 5755; 16014; 58328 +MAP3K5 ASK1 Q99683 human MKK6 5608 P52564 MAP2K6 human S207 448194 IsGyLVDsVAKtIDA Pkinase X 9231; 12280 +MAP3K5 ASK1 Q99683 human P38A 1432 Q16539 MAPK14 human T180 447970 RHtDDEMtGyVAtRW Pkinase X 9211; 9215; 4551; 9216; 4552; 4631; 4511; 4092; 9219; 24678; 8632; 6908; 41768; 51255; 14594; 14598; 62979 +MAP3K5 ASK1 Q99683 human STRAP 11171 Q9Y3F4 STRAP human S179 11267003 AtMtEVKsLNFNMSV X +MAP3K5 ASK1 Q99683 human ZNF622 90441 Q969S3 ZNF622 human T318 20765000 kGksFYStEAVQAHM zf-C2H2_2 X X +MAP3K5 ASK1 Q99683 human DAXX 1616 Q9UER7 DAXX human S184 10438000 QsPRTRGsRRQIQRL X X +MAP3K5 ASK1 Q99683 human EB1 22919 Q15691 MAPRE1 human T206 59049802 QVNVLKLtVEDLEkE X X +MAP3K5 ASK1 Q99683 human EB1 22919 Q15691 MAPRE1 human T154 31883043 NkPkkPLtssSAAPQ X X +MAP3K5 ASK1 Q99683 human ASK1 4217 Q99683 MAP3K5 human T813 990312 GDNVLINtySGVLKI Pkinase X +MAP3K5 ASK1 Q99683 human MKK4 6416 P45985 MAP2K4 human T261 447656 LVDsIAKtRDAGCRP Pkinase X 9151; 9156 +MAP3K5 ASK1 Q99683 human PDK1 5170 O15530 PDPK1 human S394 12729600 QVSSSSssHsLsASD X +MAP3K5 ASK1 Q99683 human P38A 1432 Q16539 MAPK14 human Y182 447971 tDDEMtGyVAtRWYR Pkinase X 9211; 9215; 4551; 9216; 4552; 4631; 4511; 4092; 9219; 24678; 8632; 6908; 41768; 51255; 14594; 14598; 62979 +MAP3K5 ASK1 Q99683 human ASK1 4217 Q99683 MAP3K5 human S966 447736 NEYLRsIsLPVPVLV X 3764 +Srpk1 SRPK1 O70551 mouse PRM2 19119 P07978 Prm2 mouse S69 1868017300 RIHKRRRsCRRRRRH Protamine_P2 X +Srpk1 SRPK1 O70551 mouse PRM2 19119 P07978 Prm2 mouse S8 36700142 MVRYRMRsPsEGPHQ Protamine_P2 X +Srpk1 SRPK1 O70551 mouse PRM1 19118 P02319 Prm1 mouse S9 451410 ARYRCCRsKSRSRCR Protamine_P1 X X +Srpk1 SRPK1 O70551 mouse PRM1 19118 P02319 Prm1 mouse S43 36699681 RCCRRRRsYTIRCKK Protamine_P1 X X +Srpk1 SRPK1 O70551 mouse PRM2 19119 P07978 Prm2 mouse S10 36700145 RYRMRsPsEGPHQGP Protamine_P2 X +Srpk1 SRPK1 O70551 mouse PRM2 19119 P07978 Prm2 mouse S56 451411 HHRHRRCsRKRLHRI Protamine_P2 X +Cdk4 CDK4 P30285 mouse C/EBP-alpha 12606 P53566 Cebpa mouse S193 1868113505 PPPHPHAsPAHLAAP X X +Cdk4 CDK4 P30285 mouse Rb 19645 P13405 Rb1 mouse T819 447984 LPtPtKMtPRSRILV Rb_C X +Cdk4 CDK4 P30285 mouse Rb 19645 P13405 Rb1 mouse S804 448717 IyIsPLksPyKIsEG Rb_C X 9308; 8974; 4277; 40283; 8957; 8516; 11917; 41359; 75864 +Cdk4 CDK4 P30285 mouse IRS2 384783 P81122 Irs2 mouse S388 1984215 sVAGsPLsPGPVRAP X +Cdk4 CDK4 P30285 mouse ATOH1 11921 P48985 Atoh1 mouse S309 57761909 MMAQKDLsPsLPGGI X +Cdk4 CDK4 P30285 mouse UBF 21429 P25976 Ubtf mouse S484 450180 DRGKLPEsPKRAEEI HMG_box_5 X +Cdk4 CDK4 P30285 mouse SMAD3 4088 P84022 SMAD3 human T179 451177 PQSNIPEtPPPGYLS X +Cdk4 CDK4 P30285 mouse SMAD3 4088 P84022 SMAD3 human S213 451180 NLsPNPMsPAHNNLD X +Cdk4 CDK4 P30285 mouse Rb 19645 P13405 Rb1 mouse S243 447975 AAIPINGsPRtPRRG X +Cdk4 CDK4 P30285 mouse SMAD3 4088 P84022 SMAD3 human T8 452179 MSSILPFtPPIVkRL X +Cdk4 CDK4 P30285 mouse Rb 19645 P13405 Rb1 mouse T246 449821 PINGsPRtPRRGQNR X +Cdk4 CDK4 P30285 mouse Rb 19645 P13405 Rb1 mouse S800 447980 PGGNIyIsPLksPyK Rb_C X 9308; 8974; 4277; 40283; 8957; 8516; 11917; 41359; 75864; 72443 +EPHA8 EphA8 P29322 human GLO1 2739 Q04760 GLO1 human Y136 463450 GIAVPDVysACkRFE Glyoxalase X +Dclk1 DCAMKL1 Q9JLM8 mouse RPRC1 245877 A2AJI0 Map7d1 mouse S275 4688707 INKRLsksSAtLWNs X +Dclk1 DCAMKL1 Q9JLM8 mouse RPRC1 245877 A2AJI0 Map7d1 mouse S315 4170020 sFLARsRsAVtLPRN X +Dclk1 DCAMKL1 Q9JLM8 mouse RPRC1 245877 A2AJI0 Map7d1 mouse S308 41454179 RLMtPTLsFLARsRs X +Dclk1 DCAMKL1 Q9JLM8 mouse DCAMKL1 13175 Q9JLM8 Dclk1 mouse S382 450201 DELGRRHsLQRGWRR X +Eif2ak4 GCN2 Q9QZ05 mouse eIF2-alpha 13665 Q6ZWX6 Eif2s1 mouse S52 447635 MILLSELsRrrIRSI S1 X 3597; 9721; 3398; 5199; 53085; 95797 +MAP3K13 LZK O43283 human TRIM25 7706 Q14258 TRIM25 human S12 1868624700 CPLAEELsCSICLEP X X +PHKA1 PHKA1 P18688 rabbit PHKA1 100303771 P18688 PHKA1 rabbit S972 455914 KEFGVERsVRPTDSN X +PHKA1 PHKA1 P18688 rabbit PHKA1 100303771 P18688 PHKA1 rabbit S1007 455916 TGIMQLKsEIKQVEF X +PHKA1 PHKA1 P18688 rabbit PHKA1 100303771 P18688 PHKA1 rabbit S985 455915 SNVSPAIsIHEIGAV X +Csk CSK P32577 rat Src 396442 P00523 SRC chicken Y527 448235 FTSTEPQyQPGENL_ X 2105 +Csk CSK P32577 rat FGR 79113 Q6P6U0 Fgr rat Y511 448121 FTSTEPQyQPGDQT_ X +Csk CSK P32577 rat Src 83805 Q9WUD9 Src rat Y530 448235 FTSTEPQyQPGENL_ X 2105 +UL97 UL97 P16788 herpesvirus Rb 5925 P06400 RB1 human S780 447978 strPPtLsPIPHIPr Rb_C X 9307; 3590; 8180 +UL97 UL97 P16788 herpesvirus Rb 5925 P06400 RB1 human T356 447981 DsFEtQRtPRksNLD X 81403; 99158 +UL97 UL97 P16788 herpesvirus Rb 5925 P06400 RB1 human T826 447984 LPtPtkMtPRsRILV Rb_C X +UL97 UL97 P16788 herpesvirus Rb-like 2 5934 Q08999 RBL2 human S672 448254 tLyDRySsPPAsTtR X +UL97 UL97 P16788 herpesvirus Rb 5925 P06400 RB1 human S795 447979 sPykFPssPLrIPGG Rb_C X 9301 +UL97 UL97 P16788 herpesvirus Rb 5925 P06400 RB1 human S788 450022 PIPHIPrsPykFPss Rb_C X +UL97 UL97 P16788 herpesvirus Rb 5925 P06400 RB1 human S612 447977 MyLsPVRsPKKKGsT X +UL97 UL97 P16788 herpesvirus SAMHD1 25939 Q9Y3Z3 SAMHD1 human S278 468673 QIVGPLEsPVEDSLW HD X +UL97 UL97 P16788 herpesvirus Rb 5925 P06400 RB1 human T821 447983 kIsEGLPtPtkMtPR Rb_C X 31433 +UL97 UL97 P16788 herpesvirus Rb 5925 P06400 RB1 human T373 447982 VNVIPPHtPVRTVMN RB_A X +UL97 UL97 P16788 herpesvirus SAMHD1 25939 Q9Y3Z3 SAMHD1 human T592 468674 DVIAPLItPQkkEWN X X 89930; 87593; 55092; 45205 +UL97 UL97 P16788 herpesvirus Rb 5925 P06400 RB1 human S608 447976 tAADMyLsPVRsPKK X 2181; 8147 +UL97 UL97 P16788 herpesvirus Rb 5925 P06400 RB1 human S807 447980 PGGNIyIsPLksPyk Rb_C X 9308; 8974; 4277; 40283; 8957; 8516; 11917; 99274; 41359; 75864; 72443 +UL97 UL97 P16788 herpesvirus Rb 5925 P06400 RB1 human S811 448717 IyIsPLksPykIsEG Rb_C X 9308; 8974; 4277; 40283; 8957; 8516; 11917; 41359; 75864; 63276 +PRKACA PKACA Q8MJ44 dog Lasp-1 100009568 O77506 LASP1 rabbit S146 448836 AEPERRDsQDSSNYR X X +PRKACA PKACA Q8MJ44 dog PLB 414755 P61012 PLN dog S16 448114 RSAIRRAstIEMPQQ Phospholamban X 8496 +PRKACA PKACA Q8MJ44 dog PLB 414755 P61012 PLN dog T17 448115 SAIRRAstIEMPQQA Phospholamban X 8496 +PRKACA PKACA Q8MJ44 dog Lasp-1 100009568 O77506 LASP1 rabbit S99 450464 KNKGRGFsVVADTPE X X +CAMK1G CAMK1G Q96NX5 human EIF4G3 8672 O43432 EIF4G3 human S1156 2915400 NTFMRGGssKDLLDN X X +CKB CKB P12277 human P130Cas 9564 P56945 BCAR1 human Y327 448780 PLLREEtyDVPPAFA X X +KDR VEGFR2 P35968 human profilin 1 5216 P07737 PFN1 human Y129 450514 GLINkkCyEMAsHLR Profilin X +KDR VEGFR2 P35968 human VEGFR2 3791 P35968 KDR human Y1054 447899 FGLARDIykDPDyVR PK_Tyr_Ser-Thr X X +KDR VEGFR2 P35968 human VEGFR2 3791 P35968 KDR human Y1175 447901 AQQDGKDyIVLPISE X X 2478; 3770 +KDR VEGFR2 P35968 human VEGFR2 3791 P35968 KDR human Y1214 447902 VCDPKFHyDNtAGIS X X 2477 +KDR VEGFR2 P35968 human VEGFR2 3791 P35968 KDR human Y951 447903 RFRQGKDyVGAIPVD PK_Tyr_Ser-Thr X X 2476; 2471; 4991 +KDR VEGFR2 P35968 human VEGFR2 3791 P35968 KDR human Y996 447904 EEAPEDLyKDFLTLE PK_Tyr_Ser-Thr X X 2474 +KDR VEGFR2 P35968 human VEGFR2 3791 P35968 KDR human Y1059 447900 DIykDPDyVRKGDAR PK_Tyr_Ser-Thr X X +KDR VEGFR2 P35968 human profilin 1 513895 P02584 PFN1 cow Y129 450514 GMINKKCyEMASHLR Profilin X +GRK5 GRK5 P34947 human ADRB2 154 P07550 ADRB2 human S396 457440 GHQGtVPsDNIDsQG X +GRK5 GRK5 P34947 human Moesin 4478 P26038 MSN human T66 18911798 LkLNKkVtAQDVrkE FERM_N X X +GRK5 GRK5 P34947 human GRK5 2869 P34947 GRK5 human T485 451512 LDIEQFstVkGVNLD X +GRK5 GRK5 P34947 human GPBAR1 151306 Q8TDU6 GPBAR1 human S324 1877729206 YHPSsQssVDLDLN_ X +GRK5 GRK5 P34947 human HIP 6767 P50502 ST13 human S346 21006300 AQNPANMskYQsNPk STI1 X X +GRK5 GRK5 P34947 human GPBAR1 151306 Q8TDU6 GPBAR1 human S323 1877729204 AYHPSsQssVDLDLN X +GRK5 GRK5 P34947 human ADRB2 154 P07550 ADRB2 human S407 457443 DsQGRNCstNDsLL_ X +GRK5 GRK5 P34947 human FZD6 8323 O60353 FZD6 human S648 1275585104 sVSESARsEGRIsPK X +GRK5 GRK5 P34947 human GRK5 2869 P34947 GRK5 human T10 50780063 LENIVANtVLLkARE X +GRK5 GRK5 P34947 human SNCA 6622 P37840 SNCA human S129 448278 NEAyEMPsEEGyQDy Synuclein X X 23706; 87281 +GRK5 GRK5 P34947 human ADRB2 154 P07550 ADRB2 human S411 457444 RNCstNDsLL_____ X +GRK5 GRK5 P34947 human ADRB2 154 P07550 ADRB2 human S355 458916 KAyGNGyssNGNtGE X X +GRK5 GRK5 P34947 human ADRB2 154 P07550 ADRB2 human T393 457439 DFVGHQGtVPsDNID X +GRK5 GRK5 P34947 human GPBAR1 151306 Q8TDU6 GPBAR1 human S321 1877729202 SIAYHPSsQssVDLD X +GRK5 GRK5 P34947 human GPBAR1 151306 Q8TDU6 GPBAR1 human S310 1877729200 WGRASRDsPGPSIAY X +GRK5 GRK5 P34947 human MOR-1 18390 P42866 Oprm1 mouse S375 447784 QNtREHPstANtVDR X 3451 +GRK5 GRK5 P34947 human ADRB2 154 P07550 ADRB2 human S401 457441 VPsDNIDsQGRNCst X +GRK5 GRK5 P34947 human ADRB2 154 P07550 ADRB2 human S356 458917 AyGNGyssNGNtGEQ X X +GRK5 GRK5 P34947 human CMKOR1 12778 P56485 Ackr3 mouse T352 4709314 DAsRVsEtEysALEQ X +GRK5 GRK5 P34947 human CMKOR1 12778 P56485 Ackr3 mouse S350 4709309 LIDAsRVsEtEysAL X +GRK5 GRK5 P34947 human ADRB2 154 P07550 ADRB2 human T384 457437 LCEDLPGtEDFVGHQ X +GRK5 GRK5 P34947 human GRK5 2869 P34947 GRK5 human S484 451511 VLDIEQFstVkGVNL X +GRK5 GRK5 P34947 human HDAC6 10013 Q9UBN7 HDAC6 human S22 453006 RsRQNPQsPPQDSsV X X +GRK5 GRK5 P34947 human p53 7157 P04637 TP53 human T55 450685 DDIEQWFtEDPGPDE TAD2 X X +CSNK2A2 CK2A2 P19784 human CTNNB1 1499 P35222 CTNNB1 human T112 3075001 EGMQIPstQFdAAHP X +CSNK2A2 CK2A2 P19784 human SMC3 9126 Q9UQE7 SMC3 human S1067 453059 GDVEGsQsQDEGEGs SMC_N X +CSNK2A2 CK2A2 P19784 human CK2B 1460 P67870 CSNK2B human S3 447647 _____MsssEEVsWI X +CSNK2A2 CK2A2 P19784 human CCNH 902 P51946 CCNH human T315 455993 KHEEEEWtDDDLVEs X +CSNK2A2 CK2A2 P19784 human XRCC1 7515 P18887 XRCC1 human T523 451448 AGstDENtDsEEHQE X +CSNK2A2 CK2A2 P19784 human CDC37 11140 Q16543 CDC37 human S13 450034 VWDHIEVsDDEDETH CDC37_N X 13248 +CSNK2A2 CK2A2 P19784 human CTNNB1 1499 P35222 CTNNB1 human T102 3075002 RAAMFPEtLDEGMQI X +CSNK2A2 CK2A2 P19784 human p73 7161 O15350 TP73 human T27 2063601 SSLEPDStyFDLPQS X X +CSNK2A2 CK2A2 P19784 human TYMS 7298 P04818 TYMS human S124 13209303 FLDsLGFsTREEGDL Thymidylat_synt X +CSNK2A2 CK2A2 P19784 human CDC37 114562 Q63692 Cdc37 rat S13 450034 VWDHIEVsDDEDETH CDC37_N X 13248 +CSNK2A2 CK2A2 P19784 human NKX3-1 4824 Q99801 NKX3-1 human T93 464288 EAEtLAEtEPERHLG X X +CSNK2A2 CK2A2 P19784 human XRCC1 7515 P18887 XRCC1 human T488 451452 GAEDsGDtEDELRRV X +CSNK2A2 CK2A2 P19784 human SUZ12 23512 Q15022 SUZ12 human S583 4170593 PQEMEVDsEDEKDPE VEFS-Box X X +CSNK2A2 CK2A2 P19784 human SRPK1 6732 Q96SB4 SRPK1 human S555 456013 DYLFEPHsGEEYTRD Pkinase X +CSNK2A2 CK2A2 P19784 human XRCC1 7515 P18887 XRCC1 human S485 451510 QDNGAEDsGDtEDEL X +CSNK2A2 CK2A2 P19784 human SRPK1 6732 Q96SB4 SRPK1 human S51 456012 QEEEILGsDDDEQED X +CSNK2A2 CK2A2 P19784 human CTNNB1 1499 P35222 CTNNB1 human S29 3075000 VsHWQQQsyLDsGIH X +CSNK2A2 CK2A2 P19784 human XRCC1 7515 P18887 XRCC1 human S518 451449 GEDPyAGstDENtDs X +CSNK2A2 CK2A2 P19784 human XRCC1 7515 P18887 XRCC1 human T519 451450 EDPyAGstDENtDsE X +CSNK2A2 CK2A2 P19784 human FMR1 14265 P35922 Fmr1 mouse S499 469583 NSEAsNAsETESDHR FXMRP1_C_core X +CSNK2A2 CK2A2 P19784 human NKX3-1 4824 Q99801 NKX3-1 human T89 464287 AAPEEAEtLAEtEPE X X +CSNK2A2 CK2A2 P19784 human HSF1 3297 Q00613 HSF1 human T142 449066 DsVTKLLtDVQLMKG X X +CSNK2A2 CK2A2 P19784 human CK2B 1460 P67870 CSNK2B human S2 447646 ______MsssEEVsW X +ACVRL1 ALK1 P37023 human ENG 2022 P17813 ENG human S646 12064201 StNHSIGsTQstPCS X +ACVRL1 ALK1 P37023 human ENG 2022 P17813 ENG human T640 465627 AssESSStNHSIGsT X +ACVRL1 ALK1 P37023 human ENG 2022 P17813 ENG human T654 465628 TQstPCStSSMA___ X +ACVRL1 ALK1 P37023 human ENG 2022 P17813 ENG human S649 12064200 HSIGsTQstPCStSS X +Camkk1 CAMKK1 P97756 rat CAMK1A 171503 Q63450 Camk1 rat T177 448527 DPGSVLStACGTPGY Pkinase X +Camkk1 CAMKK1 P97756 rat AMPKA1 65248 P54645 Prkaa1 rat T183 448786 SDGEFLRtsCGSPNY Pkinase X 2535; 2531; 4188; 5256; 50081; 74281 +Camkk1 CAMKK1 P97756 rat CAMKK1 60341 P97756 Camkk1 rat S24 2864201 VERVAAIsVAHLEEA X +Camkk1 CAMKK1 P97756 rat CAMK4 25050 P13234 Camk4 rat T196 448164 EHQVLMktVCGtPGY Pkinase X +Camkk1 CAMKK1 P97756 rat CAMK4 25050 P13234 Camk4 rat T200 450234 LMktVCGtPGYCAPE Pkinase X +LRRK2 LRRK2 Q5S007 human Tau iso8 4137 P10636-8 MAPT human T231 449079 KKVAVVRtPPKsPss X 20473; 71429 +LRRK2 LRRK2 Q5S007 human LRRK2 120892 Q5S007 LRRK2 human T2031 10426322 CCRMGIKtsEGtPGF Pkinase X +LRRK2 LRRK2 Q5S007 human RAB10 10890 P61026 RAB10 human T73 471953 AGQERFHtITtsYYR Ras X X +LRRK2 LRRK2 Q5S007 human LRRK2 120892 Q5S007 LRRK2 human T424 13204421 ASANALStLLEQNVN X +LRRK2 LRRK2 Q5S007 human Radixin 5962 P35241 RDX human T564 448374 AGRDKyKtLRQIRQG ERM_C X 3141; 3726; 32600 +LRRK2 LRRK2 Q5S007 human LRRK2 120892 Q5S007 LRRK2 human T1967 11554400 QQDKASLtRtLQHRI Pkinase X +LRRK2 LRRK2 Q5S007 human DNAJC6 9829 O75061 DNAJC6 human S570 2518108 sATstSAsPtLRVGE X +LRRK2 LRRK2 Q5S007 human RAB12 19328 P35283 Rab12 mouse S105 487152 AGQERFNsITSAYYR Ras X +LRRK2 LRRK2 Q5S007 human LRRK2 120892 Q5S007 LRRK2 human Y1485 15785710 GFPAIRDyHFVNAtE X +LRRK2 LRRK2 Q5S007 human TUBB3 Q2T9S0 TUBB3 cow T107 4345618 NWAKGHYtEGAELVD Tubulin X +LRRK2 LRRK2 Q5S007 human LRRK2 120892 Q5S007 LRRK2 human Y1402 15785703 FAGREEFystHPHFM Roc X +LRRK2 LRRK2 Q5S007 human Ezrin 7430 P15311 EZR human T567 448104 QGRDkyKtLRQIRQG ERM_C X 3141; 3726; 32600 +LRRK2 LRRK2 Q5S007 human LRRK2 120892 Q5S007 LRRK2 human S1853 15785708 PRLtIPIsQIAPDLI X +LRRK2 LRRK2 Q5S007 human LRRK2 120892 Q5S007 LRRK2 human T1503 10426325 ALAKLRKtIINEsLN X X +LRRK2 LRRK2 Q5S007 human RAB5B 5869 P61020 RAB5B human T6 38546301 __MTSRStARPNGQP X X +LRRK2 LRRK2 Q5S007 human LRRK2 120892 Q5S007 LRRK2 human S955 4725908 RKRKILssDDsLRSs X +LRRK2 LRRK2 Q5S007 human LRRK2 120892 Q5S007 LRRK2 human S1292 13204416 PNEMGKLsKIWDLPL LRR_4 X X 65837 +LRRK2 LRRK2 Q5S007 human LRRK2 120892 Q5S007 LRRK2 human T1404 10426330 GREEFystHPHFMtQ Roc X +LRRK2 LRRK2 Q5S007 human ASK1 4217 Q99683 MAP3K5 human T838 448394 GINPCTEtFTGtLQY Pkinase X 3765 +LRRK2 LRRK2 Q5S007 human LRRK2 120892 Q5S007 LRRK2 human S973 4725913 SHMRHsDsIssLAsE X +LRRK2 LRRK2 Q5S007 human LRRK2 120892 Q5S007 LRRK2 human T838 13204423 KQtNIAstLARMVIR X +LRRK2 LRRK2 Q5S007 human RAB29 171122 Q63481 Rab29 rat S72 396518800 AGQERFTsMTRLYYR Ras X X +LRRK2 LRRK2 Q5S007 human Akt1 207 P31749 AKT1 human S473 447855 RPHFPQFsysAsGtA Pkinase_C X X 9271; 3787; 4060; 4051; 5102; 4058; 2336; 2337; 4075; 4070; 5012; 4071; 92982; 5315; 9563; 9018; 12694; 52240; 11962; 15116; 88106; 26580; 68035; 31957; 23430; 20235 +LRRK2 LRRK2 Q5S007 human LRRK2 120892 Q5S007 LRRK2 human S1457 15785720 VGtHLDVsDEKQRKA X +LRRK2 LRRK2 Q5S007 human LRRK2 120892 Q5S007 LRRK2 human T1491 10426326 DyHFVNAtEESDALA X +LRRK2 LRRK2 Q5S007 human LRRK2 120892 Q5S007 LRRK2 human S1443 15785705 FNIKARAsssPVILV Roc X +LRRK2 LRRK2 Q5S007 human Tau iso8 4137 P10636-8 MAPT human T263 487454 VKskIGstENLkHQP Tubulin-binding X +LRRK2 LRRK2 Q5S007 human NSF 4905 P46459 NSF human T645 53340201 RKLLIIGtTSRKDVL AAA X +LRRK2 LRRK2 Q5S007 human LRRK2 120892 Q5S007 LRRK2 human T1470 15785716 KACMsKItKELLNKR X +LRRK2 LRRK2 Q5S007 human DRP1 10059 O00429 DNM1L human T595 28716001 NWRGMLktSkAEELL X X +LRRK2 LRRK2 Q5S007 human LRRK2 120892 Q5S007 LRRK2 human T1343 10426319 KLMIVGNtGsGKttL Roc X +LRRK2 LRRK2 Q5S007 human LRRK2 120892 Q5S007 LRRK2 human T1969 11554401 DKASLtRtLQHRIAL Pkinase X +LRRK2 LRRK2 Q5S007 human LRRK2 120892 Q5S007 LRRK2 human S1253 15785719 RVEKLHLsHNKLKEI LRR_4 X +LRRK2 LRRK2 Q5S007 human HDAC3 8841 O15379 HDAC3 human S424 455624 DHDNDKEsDVEI___ X 3815 +LRRK2 LRRK2 Q5S007 human LRRK2 120892 Q5S007 LRRK2 human S1345 10426331 MIVGNtGsGKttLLQ Roc X +LRRK2 LRRK2 Q5S007 human LRRK2 120892 Q5S007 LRRK2 human S935 4725898 NLQRHsNsLGPIFDH X X 59576 +LRRK2 LRRK2 Q5S007 human Tau iso8 4137 P10636-8 MAPT human T153 449076 DGKtKIAtPRGAAPP X X +LRRK2 LRRK2 Q5S007 human APP 351 P05067 APP human T743 448523 VEVDAAVtPEERHLS APP_amyloid X X 3823; 6986 +LRRK2 LRRK2 Q5S007 human Tau iso8 4137 P10636-8 MAPT human T149 487446 AKGADGKtKIAtPRG X X +LRRK2 LRRK2 Q5S007 human TUBB2B Q6B856 TUBB2B cow T107 4611909 NWAKGHYtEGAELVD Tubulin X +LRRK2 LRRK2 Q5S007 human LRRK2 120892 Q5S007 LRRK2 human S2032 3306338 CRMGIKtsEGtPGFR Pkinase X +LRRK2 LRRK2 Q5S007 human AP2M1 1173 Q96CW1 AP2M1 human T156 448782 SQItsQVtGQIGWRR X X 3843; 7399 +LRRK2 LRRK2 Q5S007 human ASK1 4217 Q99683 MAP3K5 human T825 34366326 LKIsDFGtSkRLAGI Pkinase X X +LRRK2 LRRK2 Q5S007 human SQSTM1 8878 Q13501 SQSTM1 human T138 900975704 CNGPVVGtRYkCsVC ZZ X X +LRRK2 LRRK2 Q5S007 human LRRK2 120892 Q5S007 LRRK2 human S1913 15785702 KIFNKHtsLRLLRQE Pkinase X +LRRK2 LRRK2 Q5S007 human LRRK2 120892 Q5S007 LRRK2 human S1444 15785707 NIKARAsssPVILVG Roc X +LRRK2 LRRK2 Q5S007 human RPS11 6205 P62280 RPS11 human T28 27460386 kRVLLGEtGkEkLPR Ribosomal_S17_N X +LRRK2 LRRK2 Q5S007 human RAB8A 4218 P61006 RAB8A human T72 4709152 AGQERFRtITTAyyR Ras X X +LRRK2 LRRK2 Q5S007 human LRRK2 120892 Q5S007 LRRK2 human T2524 15785717 LAEKMRRtSVE____ X +LRRK2 LRRK2 Q5S007 human LRRK2 120892 Q5S007 LRRK2 human T776 13204419 QDVRKALtISIGKGD X +LRRK2 LRRK2 Q5S007 human LRRK2 120892 Q5S007 LRRK2 human T1452 10426327 sPVILVGtHLDVsDE Roc X +LRRK2 LRRK2 Q5S007 human LRRK2 120892 Q5S007 LRRK2 human S1283 15785712 SYNLELRsFPNEMGK LRR_4 X +LRRK2 LRRK2 Q5S007 human LRRK2 120892 Q5S007 LRRK2 human T1368 13204422 DLGMQSAtVGIDVKD Roc X +LRRK2 LRRK2 Q5S007 human LRRK2 120892 Q5S007 LRRK2 human T1410 10426324 stHPHFMtQRALYLA Roc X X +LRRK2 LRRK2 Q5S007 human LRRK2 120892 Q5S007 LRRK2 human T1612 15785700 KIMAQILtVKVEGCP COR X +LRRK2 LRRK2 Q5S007 human LRRK2 120892 Q5S007 LRRK2 human S1403 10426321 AGREEFystHPHFMt Roc X +LRRK2 LRRK2 Q5S007 human LRRK2 120892 Q5S007 LRRK2 human S910 4725893 LVKKKsNsIsVGEFY X +LRRK2 LRRK2 Q5S007 human LRRK2 120892 Q5S007 LRRK2 human S1467 15785704 KQRKACMsKItKELL X +LRRK2 LRRK2 Q5S007 human RAB10 19325 P61027 Rab10 mouse T73 471953 AGQERFHtITTSYYR Ras X +LRRK2 LRRK2 Q5S007 human LRRK2 120892 Q5S007 LRRK2 human T1849 15785709 NPDQPRLtIPIsQIA X +LRRK2 LRRK2 Q5S007 human p53 7157 P04637 TP53 human T377 3309800 kskkGQstsRHkkLM X X +LRRK2 LRRK2 Q5S007 human LRRK2 120892 Q5S007 LRRK2 human T1357 15785718 LLQQLMKtKKSDLGM Roc X +LRRK2 LRRK2 Q5S007 human LARS 51520 Q9P2J5 LARS1 human T293 1345849602 NIFLVAAtLRPETMF tRNA-synt_1 X X +LRRK2 LRRK2 Q5S007 human RPS11 6205 P62280 RPS11 human T46 33515800 NIGLGFktPkEAIEG Ribosomal_S17_N X +LRRK2 LRRK2 Q5S007 human LRRK2 120892 Q5S007 LRRK2 human S2257 15785715 CNSFSKQsKQKNFLL X +LRRK2 LRRK2 Q5S007 human LRRK2 120892 Q5S007 LRRK2 human T524 13204424 PEESREDtEFHHKLN X +LRRK2 LRRK2 Q5S007 human LRRK2 120892 Q5S007 LRRK2 human T2483 13204417 NRKNTEGtQKQKEIQ X +LRRK2 LRRK2 Q5S007 human WAVE2 242687 Q8BH43 Wasf2 mouse T96 1107491500 VSLQGINtRKAFRSS X X +LRRK2 LRRK2 Q5S007 human p53 7157 P04637 TP53 human T304 50310600 HELPPGStkRALPNN X X +LRRK2 LRRK2 Q5S007 human LRRK2 120892 Q5S007 LRRK2 human T1912 15785713 VKIFNKHtsLRLLRQ Pkinase X +LRRK2 LRRK2 Q5S007 human Tau iso8 4137 P10636-8 MAPT human T169 487447 QkGQANAtRIPAktP X +LRRK2 LRRK2 Q5S007 human FZD3 7976 Q9NPG1 FZD3 human T598 1869636102 RSRDGRYtPCSYRGM X +LRRK2 LRRK2 Q5S007 human TUBB2C Q3MHM5 TUBB2C cow T107 4611914 NWAKGHYtEGAELVD Tubulin X +LRRK2 LRRK2 Q5S007 human LRRK2 120892 Q5S007 LRRK2 human T1348 10426320 GNtGsGKttLLQQLM Roc X +LRRK2 LRRK2 Q5S007 human LRRK2 120892 Q5S007 LRRK2 human S1124 13204425 NkISGICsPLRLkEL X +LRRK2 LRRK2 Q5S007 human SYN1 24949 P09951 Syn1 rat T339 2020533 sGNWKtNtGsAMLEQ Synapsin_C X +LRRK2 LRRK2 Q5S007 human Tau iso8 4137 P10636-8 MAPT human T181 447932 ktPPAPktPPssGEP X 12885; 66224; 62672 +LRRK2 LRRK2 Q5S007 human RPS15 6209 P62841 RPS15 human T136 18913279 GRPGIGAtHssRFIP X X +LRRK2 LRRK2 Q5S007 human LRRK2 120892 Q5S007 LRRK2 human T833 13204418 tSNLRKQtNIAstLA X +LRRK2 LRRK2 Q5S007 human LRRK2 120892 Q5S007 LRRK2 human S5 13204415 ___MAsGsCQGCEED X +LRRK2 LRRK2 Q5S007 human RAB29 226422 Q91YQ1 Rab29 mouse T71 406855300 IAGQERFtSMTRLYY Ras X +LRRK2 LRRK2 Q5S007 human LRRK2 120892 Q5S007 LRRK2 human Y1332 10370351 RLKKAVPyNRMKLMI X +LRRK2 LRRK2 Q5S007 human LRRK2 120892 Q5S007 LRRK2 human T2035 477192 GIKtsEGtPGFRAPE Pkinase X +LRRK2 LRRK2 Q5S007 human Moesin 4478 P26038 MSN human T558 447706 LGRDKyKtLRQIRQG ERM_C X 3141; 3726; 32600 +LRRK2 LRRK2 Q5S007 human LRRK2 120892 Q5S007 LRRK2 human S1445 15785711 IKARAsssPVILVGt Roc X +LRRK2 LRRK2 Q5S007 human RAB8A 17274 P55258 Rab8a mouse T72 4709152 AGQERFRtITTAYYR Ras X +LRRK2 LRRK2 Q5S007 human TUBB4 Q3ZBU7 TUBB4 cow T107 9467901 NWAKGHYtEGAELVD Tubulin X +LRRK2 LRRK2 Q5S007 human Tau iso8 4137 P10636-8 MAPT human T212 447934 tPGsRsRtPsLPtPP X +LRRK2 LRRK2 Q5S007 human LRRK2 120892 Q5S007 LRRK2 human S1647 15785714 KFPKNYMsQYFKLLE COR X +LRRK2 LRRK2 Q5S007 human LRRK2 120892 Q5S007 LRRK2 human S1508 15785706 RKtIINEsLNFKIRD X +LRRK2 LRRK2 Q5S007 human LRRK2 120892 Q5S007 LRRK2 human T826 13204420 GPLFPDKtSNLRKQt X +LRRK2 LRRK2 Q5S007 human SYN1 24949 P09951 Syn1 rat T337 486180 SVsGNWKtNtGsAML Synapsin_C X +LRRK2 LRRK2 Q5S007 human LRRK2 66725 Q5S006 Lrrk2 mouse S1292 13204416 PNEMGKLsKIWDLPL LRR_4 X X 65837 +LRRK2 LRRK2 Q5S007 human TUBB Q2KJD0 TUBB5 cow T107 4345619 NWAKGHYtEGAELVD Tubulin X +LRRK2 LRRK2 Q5S007 human WAVE2 242687 Q8BH43 Wasf2 mouse T470 56675609 VVGNDVAtILsRRIA X X +LRRK2 LRRK2 Q5S007 human SNAPIN 23557 O95295 SNAPIN human T117 28761202 NHsVAKEtARRRAML X X +LRRK2 LRRK2 Q5S007 human Tau iso8 4137 P10636-8 MAPT human T205 447933 ssPGsPGtPGsRsRt X 25377; 43964; 53001; 49561; 20060; 33032; 30505; 20739; 98160 +LRRK2 LRRK2 Q5S007 human LRRK2 120892 Q5S007 LRRK2 human S1536 15785701 ELEKIILsERKNVPI COR X +LRRK2 LRRK2 Q5S007 human RPS11 6205 P62280 RPS11 human T54 15414577 PkEAIEGtyIDkkCP Ribosomal_S17_N X +LRRK2 LRRK2 Q5S007 human LRRK2 120892 Q5S007 LRRK2 human S3 13204414 _____MAsGsCQGCE X +SIK1 SIK P57059 human PANX1 55991 Q9JIP4 Panx1 mouse S205 1874115103 yLKTKKNsSHLIMKY Innexin X +SIK1 SIK P57059 human HDAC5 10014 Q9UQL6 HDAC5 human S661 7237900 QALGRTQsSPAAPGG X X +SIK1 SIK P57059 human TORC3 70461 Q91X84 Crtc3 mouse S162 7101661 SALNRTNsDSALHTS TORC_M X +SIK1 SIK P57059 human TORC3 70461 Q91X84 Crtc3 mouse S370 1210886 SLRLFsLsNPsLSTT X +SIK1 SIK P57059 human TPI1 7167 P60174 TPI1 human S21 465652 kMNGRkQsLGELIGt TIM X +SIK1 SIK P57059 human SCARB1 25073 P97943 Scarb1 rat S496 14567809 AYSESLMsPAAkGTV X +SIK1 SIK P57059 human TORC3 70461 Q91X84 Crtc3 mouse S62 3203139 LtQyHGGsLPNVSQL TORC_N X +SIK1 SIK P57059 human SREBP-1 iso4 20787 Q9WTN3-4 Srebf1 mouse S329 7996201 KSLKDLVsACGSGGG X +SIK1 SIK P57059 human TORC2 74343 Q3U182 Crtc2 mouse S171 454622 sALNRtSsDsALHTs TORC_M X +SIK1 SIK P57059 human TORC3 70461 Q91X84 Crtc3 mouse S329 468980 SGLQSsRsNPsIQAT X +SIK1 SIK P57059 human SMRT 9612 Q9Y618 NCOR2 human T1383 3217644 KLLKREGtPPPPPPs X X +SIK1 SIK P57059 human TORC2 74343 Q3U182 Crtc2 mouse S275 3174300 PAMNTGGsLPDLTNL TORC_M X X +SIK1 SIK P57059 human TORC2 74343 Q3U182 Crtc2 mouse S307 454633 PSLSGGNsTTNLTHT TORC_M X X +Ikbke IKKE Q9R0T8 mouse IkB-alpha 18035 Q9Z1E3 Nfkbia mouse S32 448203 LVDDRHDsGLDsMKD X 5210; 2859; 9246; 5209 +Ikbke IKKE Q9R0T8 mouse IKKE 56489 Q9R0T8 Ikbke mouse S172 447631 DDDEKFVsVYGTEEY Pkinase X 8766 +Ikbke IKKE Q9R0T8 mouse IkB-alpha 18035 Q9Z1E3 Nfkbia mouse S36 448204 RHDsGLDsMKDEEYE X 5210; 9246 +Ikbke IKKE Q9R0T8 mouse Snail1 20613 Q02085 Snai1 mouse S165 1876128600 YCNKEYLsLGALKMH zf-C2H2_6 X +Ikbke IKKE Q9R0T8 mouse TRAF3IP2 103213 Q8N7N6 Traf3ip2 mouse S311 21041604 KVILNDSsPQDQEER X +MAPK14 P38A Q16539 human ULK1 22241 O70405 Ulk1 mouse S757 483139 PVVFtVGsPPsGAtP X 14202; 6888; 29313 +MAPK14 P38A Q16539 human Tau iso8 4137 P10636-8 MAPT human T231 449079 KKVAVVRtPPKsPss X 20473; 71429 +MAPK14 P38A Q16539 human JTV1 7965 Q13155 AIMP2 human S156 55571504 LSTVHtHssVkSVPE Thioredoxin_16 X +MAPK14 P38A Q16539 human NHE1 6548 P19634 SLC9A1 human S726 2509107 IDPAsPQsPEsVDLV X X +MAPK14 P38A Q16539 human ATG5 11793 Q99J83 Atg5 mouse T75 27138202 IWFEYEGtPLKWHYP X +MAPK14 P38A Q16539 human MEF2D 4209 Q14814 MEF2D human S180 449933 LTDPRLLsPQQPALQ X +MAPK14 P38A Q16539 human SRC-2 17978 Q61026 Ncoa2 mouse S736 465446 tVKQEPAsPKKKENA DUF4927 X X +MAPK14 P38A Q16539 human MKL1 223701 Q8K4J6 Mrtfa mouse S492 467355 TGstPPVsPTPsERS X +MAPK14 P38A Q16539 human ATF-2 1386 P15336 ATF2 human T69 448224 sVIVADQtPtPtRFL X X 9225; 94125; 40749; 61584; 44167 +MAPK14 P38A Q16539 human STAT1 6772 P42224 STAT1 human S727 447753 TDNLLPMsPEEFDEV STAT1_TAZ2bind X 9177; 8826; 62390 +MAPK14 P38A Q16539 human Tau iso8 4137 P10636-8 MAPT human S199 447927 GDRsGyssPGsPGtP X X 29957 +MAPK14 P38A Q16539 human DDIT3 1649 P35638 DDIT3 human S79 448090 EVTSTSQsPHsPDSS X +MAPK14 P38A Q16539 human p47phox 653361 P14598 NCF1 human S348 451728 PGPQsPGsPLEEERQ X +MAPK14 P38A Q16539 human SLC6A2 6530 P23975 SLC6A2 human T30 4957152 QPLRARKtAELLVVK X +MAPK14 P38A Q16539 human NPHS1 54631 Q9QZS7 Nphs1 mouse S1160 1876873800 YYSMRDFsPQLPPTL X X +MAPK14 P38A Q16539 human ATF-2 1386 P15336 ATF2 human T71 448225 IVADQtPtPtRFLkN X X 9225; 9221; 5112; 94125; 13850; 40749; 15411; 24329; 61584; 27934; 92109; 20534; 35858 +MAPK14 P38A Q16539 human 4E-BP1 13685 Q60876 Eif4ebp1 mouse S64 447527 FLMECRNsPVAKtPP eIF_4EBP X 9451; 9456 +MAPK14 P38A Q16539 human JDP2 122953 Q8WYK2 JDP2 human T148 448312 VRtDsVKtPEsEGNP X +MAPK14 P38A Q16539 human TACE 6868 P78536 ADAM17 human T735 449804 kPFPAPQtPGRLQPA X X +MAPK14 P38A Q16539 human SIAH2 20439 Q06986 Siah2 mouse S29 471339 PQtPHAPsPAAPPAA X +MAPK14 P38A Q16539 human ELK4 2005 P28324 ELK4 human S387 4317601 LsPVAPLsPARLQGA X X +MAPK14 P38A Q16539 human p63 iso2 8626 Q9H3D4-2 TP63 human S361 451603 QKQtsIQsPSSYGNs X X +MAPK14 P38A Q16539 human SHC1 6464 P29353 SHC1 human S54 457345 PPLPGDDsPTTLCSF X +MAPK14 P38A Q16539 human NOXA1 10811 Q86UR1 NOXA1 human S239 12570901 ARsLIMDsPRAGTHQ X +MAPK14 P38A Q16539 human Tel 2120 P41212 ETV6 human S257 451378 ESHPKPSsPRQESTR X +MAPK14 P38A Q16539 human RBM17 84991 Q96I25 RBM17 human S222 3209223 EEQDRPRsPtGPsNs X +MAPK14 P38A Q16539 human ELK1 2002 P19419 ELK1 human S389 449757 LsPIAPRsPAKLSFQ X +MAPK14 P38A Q16539 human FPR1 2357 P21462 FPR1 human S342 450850 AtNstLPsAEVELQA X X +MAPK14 P38A Q16539 human PGC-1 alpha 10891 Q9UBK2 PPARGC1A human T263 448241 TTLSLPLtPEsPNDP X X +MAPK14 P38A Q16539 human smMLCK 4638 Q15746 MYLK human T978 15423395 VPPPKPAtPDFRSVL X +MAPK14 P38A Q16539 human C/EBP-alpha 24252 P05554 Cebpa rat S21 448308 PMSSHLQsPPHAPSN X 2841 +MAPK14 P38A Q16539 human Kv7.2 iso4 3785 O43526-4 KCNQ2 human S436 481665 QAQTVRRsPsADQSL KCNQ_channel X +MAPK14 P38A Q16539 human SHC1 6464 P29353 SHC1 human T386 457351 PTAPNAQtPSHLGAT X +MAPK14 P38A Q16539 human FOXC1 2296 Q12948 FOXC1 human S241 3195017 PsPPQPLsPAAALGS X +MAPK14 P38A Q16539 human MEF2D 4209 Q14814 MEF2D human S98 470518 KGFNGCDsPEPDGED HJURP_C X +MAPK14 P38A Q16539 human MZF-1 109889 O70162 Mzf1 mouse S336 448731 EEVGGIFsPGFTLQM X +MAPK14 P38A Q16539 human P38A 26416 P47811 Mapk14 mouse T180 447970 RHtDDEMtGyVAtRW Pkinase X 9211; 9215; 4551; 9216; 4552; 4631; 4511; 4092; 9219; 24678; 8632; 6908; 41768; 51255; 14594; 14598; 62979 +MAPK14 P38A Q16539 human 4E-BP1 13685 Q60876 Eif4ebp1 mouse T45 447496 GGtLFsttPGGtRII eIF_4EBP X 2855; 9459; 2846; 4923; 5123; 3929; 7547; 45613; 39788 +MAPK14 P38A Q16539 human PGC-1 alpha 10891 Q9UBK2 PPARGC1A human T299 448009 AGLtPPTtPPHKANQ X X +MAPK14 P38A Q16539 human PDX1 3651 P52945 PDX1 human S66 458402 QGsPPDIsPYEVPPL X +MAPK14 P38A Q16539 human DLX5 13395 P70396 Dlx5 mouse S217 1725301 SDPMACNsPQSPAVW X X +MAPK14 P38A Q16539 human PKR 5610 P19525 EIF2AK2 human T451 448089 kRtRSKGtLRyMsPE Pkinase X +MAPK14 P38A Q16539 human p63 8626 Q9H3D4 TP63 human S160 451600 SSTFDALsPsPAIPS X 4981 +MAPK14 P38A Q16539 human eNOS 4846 P29474 NOS3 human S600 34729904 MSGPYNSsPRPEQHK Flavodoxin_1 X X +MAPK14 P38A Q16539 human MAP4 4134 P27816 MAP4 human S696 449564 PNKELPPsPEKKTkP X +MAPK14 P38A Q16539 human CASP8 841 Q14790 CASP8 human S347 450983 FTGLkCPsLAGkPkV Peptidase_C14 X X +MAPK14 P38A Q16539 human CDT1 81620 Q9H211 CDT1 human S391 20804632 LRSAAPssPGsPrPA X X +MAPK14 P38A Q16539 human DDX5 1655 P17844 DDX5 human T446 15409321 GtAyTFFtPNNIkQV X +MAPK14 P38A Q16539 human USP21 27005 Q9UK80 USP21 human S538 63253102 VYNDSRVsPVSENQV UCH X X +MAPK14 P38A Q16539 human Mnk1 iso2 8569 Q9BUB5-2 MKNK1 human T214 447622 ITtPELTtPCGSAEY Pkinase X 2111; 43507 +MAPK14 P38A Q16539 human p53 7157 P04637 TP53 human S46 447536 AMDDLMLsPDDIEQW TAD2 X X 2521 +MAPK14 P38A Q16539 human Kv2.1 3745 Q14721 KCNB1 human S805 473562 ESsPLPtsPKFLRQN X +MAPK14 P38A Q16539 human WSTF 9031 Q9UIG0 BAZ1B human S158 3215310 ksDGACDsPssDKEN X +MAPK14 P38A Q16539 human Mnk1 8569 Q9BUB5 MKNK1 human T250 447621 NSCTPITtPELTtPC Pkinase X 2111; 43507 +MAPK14 P38A Q16539 human MEF2A 4205 Q02078 MEF2A human T319 448098 tPVVSVTtPSLPPQG X +MAPK14 P38A Q16539 human HuR 1994 Q15717 ELAVL1 human T118 474554 sGLPRTMtQkDVEDM RRM_1 X X +MAPK14 P38A Q16539 human Tau iso8 4137 P10636-8 MAPT human S396 449081 GAEIVyKsPVVsGDt X X 9632 +MAPK14 P38A Q16539 human SERT 6532 P31645 SLC6A4 human T616 7576402 IKsItPEtPTEIPCG X +MAPK14 P38A Q16539 human RCAN1 54720 Q9JHG6 Rcan1 mouse T177 8142805 WKQVEDAtPVINYDL Calcipressin X +MAPK14 P38A Q16539 human Tau iso8 4137 P10636-8 MAPT human S404 449082 PVVsGDtsPRHLsNV X X 35834; 20194; 98523; 91600; 49562 +MAPK14 P38A Q16539 human TAB1 10454 Q15750 TAB1 human T431 456223 ASTLDEAtPTLTNQs X X +MAPK14 P38A Q16539 human MAPKAPK2 9261 P49137 MAPKAPK2 human S272 448268 SNHGLAIsPGMKTRI Pkinase X X +MAPK14 P38A Q16539 human Oct7 5454 P20265 POU3F2 human S96 1868139201 DGsPWSTsPLGQPDI X +MAPK14 P38A Q16539 human S100A9 6280 P06702 S100A9 human T113 455888 KPGLGEGtP______ X +MAPK14 P38A Q16539 human MAFA 389692 Q8NHW3 MAFA human T57 456028 LSStPLStPCSsVPS X +MAPK14 P38A Q16539 human CDT1 81620 Q9H211 CDT1 human T402 20804634 PrPALPAtPPAtPPA X X +MAPK14 P38A Q16539 human RCAN1 54720 Q9JHG6 Rcan1 mouse T206 21511700 LHAATDTtPSVVVHV Calcipressin X +MAPK14 P38A Q16539 human NFAT3 4776 Q14934 NFATC4 human S168 448859 QGGGAFFsPsPGsSS X +MAPK14 P38A Q16539 human HePTP 5778 P35236 PTPN7 human S93 448310 ALQRQPPsPKQLEEE X +MAPK14 P38A Q16539 human H3 360198 P68433 H3c1 mouse S10 455676 tkQTARkstGGkAPr Histone X 9701; 9711; 9606; 3465; 3642; 3377; 3475; 3458; 5764; 47398; 8481; 8552; 53348; 29237; 66065; 43185; 64522; 52725 +MAPK14 P38A Q16539 human FOXO3A 2309 O43524 FOXO3 human S7 9318032 _MAEAPAsPAPLsPL X X 14724 +MAPK14 P38A Q16539 human Kv2.1 25736 P15387 Kcnb1 rat S799 473567 EKNHFESsPLPTsPK X +MAPK14 P38A Q16539 human EPS15 2060 P42566 EPS15 human S796 1983704 RsINkLDsPDPFkLN X X +MAPK14 P38A Q16539 human SRC-3 8202 Q9Y6Q9 NCOA3 human S860 454106 NRAVsLDsPVsVGss X X +MAPK14 P38A Q16539 human HBP1 26959 O60381 HBP1 human S402 455671 GFSkNCGsPGSSQLS X X +MAPK14 P38A Q16539 human Rb 5925 P06400 RB1 human T841 14160965 sIGEsFGtsEkFQkI Rb_C X X +MAPK14 P38A Q16539 human RPS27 6232 P42677 RPS27 human S27 4272667 KKkRLVQsPNsyFMD X +MAPK14 P38A Q16539 human TAB1 10454 Q15750 TAB1 human S452 22869801 STNTHTQssSSssDG X X +MAPK14 P38A Q16539 human FOXO3A 2309 O43524 FOXO3 human S294 472326 QLskWPGsPtsRsSD X 5538 +MAPK14 P38A Q16539 human KARS 3735 Q15046 KARS1 human S49 23117372 ELsEKQLsQAtAAAT X +MAPK14 P38A Q16539 human MEF2D 4209 Q14814 MEF2D human S251 3196577 NkVIPAksPPPPtHS X +MAPK14 P38A Q16539 human HTRA2 27429 O43464 HTRA2 human S142 487466 VPSPPPAsPRSQYNF Peptidase_M50 X +MAPK14 P38A Q16539 human MITF iso8 17342 Q08874-8 Mitf mouse S307 451221 IPSTGLCsPDLVNRI DUF3371 X +MAPK14 P38A Q16539 human MAP4 17758 P27546 Map4 mouse S737 476119 ATATARPsTLPARDV X +MAPK14 P38A Q16539 human K8 3856 P05787 KRT8 human S74 448539 tVNQsLLsPLVLEVD Keratin_2_head X X +MAPK14 P38A Q16539 human E2F4 E1BUH4 E2F4 chicken T263 25571900 STQPStPtPSSTQDH X +MAPK14 P38A Q16539 human ISL1 3670 P61371 ISL1 human S269 515814094 GTPMVAAsPERHDGG X X +MAPK14 P38A Q16539 human FGFR1 2260 P11362 FGFR1 human S777 2721300 SMPLDQysPsFPDTR X X +MAPK14 P38A Q16539 human p63 iso2 8626 Q9H3D4-2 TP63 human S68 451601 TFDALsPsPAIPSNT X X +MAPK14 P38A Q16539 human GSK3B 2932 P49841 GSK3B human T43 456221 kVTTVVAtPGQGPDR X +MAPK14 P38A Q16539 human fumarase 2271 P07954 FH human T90 3823351 GVtERMPtPVIkAFG Lyase_1 X +MAPK14 P38A Q16539 human EGFR 1956 P00533 EGFR human T1041 3178896 LLSsLsAtsNNstVA X +MAPK14 P38A Q16539 human CDX2 1045 Q99626 CDX2 human S283 456208 RsVPEPLsPVSSLQA X +MAPK14 P38A Q16539 human smMLCK 4638 Q15746 MYLK human S947 4739853 EEERKVHsPQQVDFR X +MAPK14 P38A Q16539 human SCN10A Q62968 Scn10a rat S556 2482301 PRsPLPQsPNPGRRH X X +MAPK14 P38A Q16539 human Oct7 5454 P20265 POU3F2 human T440 4928201 PPHHGVQtPVQ____ X +MAPK14 P38A Q16539 human TAB1 10454 Q15750 TAB1 human S456 22869802 HTQssSSssDGGLFR X X +MAPK14 P38A Q16539 human NFAT3 4776 Q14934 NFATC4 human S170 448860 GGAFFsPsPGsSSLS X +MAPK14 P38A Q16539 human CBX4 8535 O00257 CBX4 human T497 470079 SLQVkPEtPASAAVA X X +MAPK14 P38A Q16539 human USF1 7391 P22415 USF1 human T153 463815 EALLGQAtPPGTGQF X +MAPK14 P38A Q16539 human MAPKAPK2 17164 P49138 Mapkapk2 mouse T320 448273 QsTKVPQtPLHtsRV X 3007; 3041 +MAPK14 P38A Q16539 human XBP1 22433 O35426 Xbp1 mouse S61 21688102 RQRLTHLsPEEKALR bZIP_1 X +MAPK14 P38A Q16539 human MEF2C iso3 4208 Q06413-3 MEF2C human T300 448001 tPVVSVAtPTLPGQG X +MAPK14 P38A Q16539 human Rab7 7879 P51149 RAB7A human S72 468547 AGQERFQsLGVAFYR Ras X +MAPK14 P38A Q16539 human TBX2 21385 Q60707 Tbx2 mouse S336 1308918 PAREPPPsPSAAPsP TBX X X +MAPK14 P38A Q16539 human p53 7157 P04637 TP53 human S33 447531 LPENNVLsPLPsQAM X X 2526 +MAPK14 P38A Q16539 human MZF-1 109889 O70162 Mzf1 mouse S374 448856 SLSGQIQsPTTEGGF X +MAPK14 P38A Q16539 human SRC-3 8202 Q9Y6Q9 NCOA3 human S543 454108 SLLSTLSsPGPKLDN NCOA_u2 X +MAPK14 P38A Q16539 human AR 367 P10275 AR human S651 448414 GEASSTTsPTEETTQ X X +MAPK14 P38A Q16539 human p63 8626 Q9H3D4 TP63 human S162 451601 TFDALsPsPAIPSNT X 4981 +MAPK14 P38A Q16539 human osterix 170574 Q8VI67 Sp7 mouse S73 15334100 SSTNGLLsPAGsPPA X X +MAPK14 P38A Q16539 human Rb 5925 P06400 RB1 human T252 449821 PINGsPRtPRRGQNR X X +MAPK14 P38A Q16539 human MEF2A 4205 Q02078 MEF2A human S223 7533200 VPNGAGSsPVGNGFV X +MAPK14 P38A Q16539 human STAT3 6774 P40763 STAT3 human S727 448191 NtIDLPMsPrTLDSL X 9134; 9136; 34911; 94994; 49081; 58978; 87544; 71958; 50804 +MAPK14 P38A Q16539 human BUB3 9184 O43684 BUB3 human S211 452546 AVEyLDPsPEVQkkk X X +MAPK14 P38A Q16539 human FOXO3A 2309 O43524 FOXO3 human S425 2058400 TKGsGLGsPtSSFNS X 64616 +MAPK14 P38A Q16539 human CDT1 81620 Q9H211 CDT1 human S411 21440504 PAtPPAAsPsALkGV X X +MAPK14 P38A Q16539 human MEF2A 4205 Q02078 MEF2A human S408 449949 SIkSEPIsPPRDRMT X 9737 +MAPK14 P38A Q16539 human CDKN2D 1032 P55273 CDKN2D human S66 6046000 ELLKQGAsPNVQDTS Ank_2 X X +MAPK14 P38A Q16539 human UBE3C 100763 Q80U95 Ube3c mouse S741 1884003508 EDAYDKLsPENEPDL X +MAPK14 P38A Q16539 human Tel 2120 P41212 ETV6 human S22 468918 IsytPPEsPVPsyAs X +MAPK14 P38A Q16539 human SOX9 6662 P48436 SOX9 human S211 450957 FKALQADsPHsSSGM X +MAPK14 P38A Q16539 human GRHL3 57822 Q8TE85 GRHL3 human T454 1077816900 RPETDLEtPPVLFIP X +MAPK14 P38A Q16539 human DROSHA 29102 Q9NRR4 DROSHA human T274 25289827 sDyDrGRtPsRHRSY X X +MAPK14 P38A Q16539 human SIAH2 20439 Q06986 Siah2 mouse T24 471340 KQPPPPQtPHAPsPA X +MAPK14 P38A Q16539 human RBPJ 3516 Q06330 RBPJ human T339 23298201 STDKAEYtFYEGMGP X X +MAPK14 P38A Q16539 human p63 iso2 8626 Q9H3D4-2 TP63 human S66 451600 SSTFDALsPsPAIPS X X +MAPK14 P38A Q16539 human NHE1 6548 P19634 SLC9A1 human T718 4059100 KEDLPVItIDPAsPQ X +MAPK14 P38A Q16539 human Bcl-xL 598 Q07817 BCL2L1 human S62 449099 PSWHLADsPAVNGAT X +MAPK14 P38A Q16539 human GATA2 2624 P23769 GATA2 human S192 14573920 PsTTGAAsPASSSAG X +MAPK14 P38A Q16539 human SREBP-1 6720 P36956 SREBF1 human S63 23940711 AGGtDPAsPDTSSPG X X +MAPK14 P38A Q16539 human CRYAB 1410 P02511 CRYAB human S59 448783 PsFLRAPsWFDTGLS X +MAPK14 P38A Q16539 human eNOS 4846 P29474 NOS3 human S114 448638 RKLQGRPsPGPPAPE X X 9575 +MAPK14 P38A Q16539 human DDX5 1655 P17844 DDX5 human T564 27156800 SFRTGNPtGTYQNGY P68HR X +MAPK14 P38A Q16539 human Rb 5925 P06400 RB1 human S567 450021 SLAWLSDsPLFDLIk RB_A X X +MAPK14 P38A Q16539 human p21Cip1 1026 P38936 CDKN1A human S98 478193 GGRRPGTsPALLQGT X +MAPK14 P38A Q16539 human LAMP2 3920 P13473 LAMP2 human T213 386186606 PSPtttPtPKEKPEA X X +MAPK14 P38A Q16539 human ELK1 13712 P41969 Elk1 mouse S384 447872 IHFWSTLsPIAPRsP X 9181; 9186 +MAPK14 P38A Q16539 human Rb 5925 P06400 RB1 human S249 447975 AVIPINGsPRtPRRG X X +MAPK14 P38A Q16539 human MEF2D 4209 Q14814 MEF2D human S192 10941739 ALQRNSVsPGLPQRP X +MAPK14 P38A Q16539 human TRIM9 iso5 114088 Q9C026-5 TRIM9 human S80 1046182901 EADsGYGsYGGFASA X +MAPK14 P38A Q16539 human SREBP-1 6720 P36956 SREBF1 human T426 467200 TEVEDTLtPPPsDAG X X +MAPK14 P38A Q16539 human SMAD9 4093 O15198 SMAD9 human T136 15722873 YHYRRVEtPVLPPVL X +MAPK14 P38A Q16539 human Snail1 6615 O95863 SNAI1 human S107 455882 sQPPsPPsPAPssFS X X +MAPK14 P38A Q16539 human ULK1 22241 O70405 Ulk1 mouse S504 397383602 GGRPYTPsPQVGTIP X +MAPK14 P38A Q16539 human DDIT3 1649 P35638 DDIT3 human S82 448091 STSQsPHsPDSSQSS X +MAPK14 P38A Q16539 human ATF-2 11909 P16951 Atf2 mouse T51 448224 sVIVADQtPtPtRFL X X 9225; 94125; 40749; 61584; 44167 +MAPK14 P38A Q16539 human BMF 171543 Q91ZE9 Bmf mouse S74 11267001 DKATQtLsPAsPSQG BMF X X +MAPK14 P38A Q16539 human KHSRP 8570 Q92945 KHSRP human T692 458387 QAAyYGQtPGPGGPQ X +MAPK14 P38A Q16539 human DROSHA 29102 Q9NRR4 DROSHA human S300 14572630 RHRDNRRsPsLERSY X X +MAPK14 P38A Q16539 human ZNHIT1 10467 O43257 ZNHIT1 human T103 13419503 AEGPNYLtACAGPPS X X +MAPK14 P38A Q16539 human FOXO3A 2309 O43524 FOXO3 human S12 9318037 PAsPAPLsPLEVELD X +MAPK14 P38A Q16539 human p63 iso2 8626 Q9H3D4-2 TP63 human S301 451602 TSIKKRRsPDDELLY P53_tetramer X X +MAPK14 P38A Q16539 human GR 2908 P04150 NR3C1 human S226 451796 IDENCLLsPLAGEDD GCR X 97285 +MAPK14 P38A Q16539 human SKP2 6502 Q13309 SKP2 human S64 457412 sNLGHPEsPPRkRLk X 14865 +MAPK14 P38A Q16539 human BMF 171543 Q91ZE9 Bmf mouse S77 22999100 TQtLsPAsPSQGVML BMF X X +MAPK14 P38A Q16539 human Bcl-2 596 P10415 BCL2 human S87 448396 AAAGPALsPVPPVVH X X +MAPK14 P38A Q16539 human RBM17 84991 Q96I25 RBM17 human T71 470694 DDrQIVDtPPHVAAG X +MAPK14 P38A Q16539 human ATF6A 22926 P18850 ATF6 human T166 35527100 NKTENGLtPKKKIQV X X +MAPK14 P38A Q16539 human Kv2.1 25736 P15387 Kcnb1 rat S804 473562 ESsPLPTsPKFLRPN X +MAPK14 P38A Q16539 human PXN 5829 P49023 PXN human S85 451054 HQQPQsssPVyGsSA Paxillin X X +MAPK14 P38A Q16539 human MEF2A 4205 Q02078 MEF2A human S192 7533201 TTLHRNVsPGAPQRP X +MAPK14 P38A Q16539 human GR 2908 P04150 NR3C1 human S203 447967 DLEFSSGsPGkEtNE GCR X X +MAPK14 P38A Q16539 human BMF 171543 Q91ZE9 Bmf mouse T72 1874396402 QEDKATQtLsPAsPS BMF X +MAPK14 P38A Q16539 human Caldesmon 281660 NP_776683 CALD1 cow S531 448466 QSVDKVTsPTKV___ X +MAPK14 P38A Q16539 human MEF2A 4205 Q02078 MEF2A human S98 485623 KEHRGCDsPDPDtsy HJURP_C X +MAPK14 P38A Q16539 human MKL1 223701 Q8K4J6 Mrtfa mouse T488 469405 KFGsTGstPPVsPTP X +MAPK14 P38A Q16539 human Tau iso8 4137 P10636-8 MAPT human S202 447928 sGyssPGsPGtPGsR X X 39357; 30505 +MAPK14 P38A Q16539 human DROSHA 29102 Q9NRR4 DROSHA human S255 40274400 DRRERGRsPDRRRQD X X +MAPK14 P38A Q16539 human FOXC2 2303 Q99958 FOXC2 human S367 28129600 DHPSGPTsPLSALNL X X +MAPK14 P38A Q16539 human SREBP-1 iso3 6720 P36956-3 SREBF1 human S39 23940711 AGGTDPAsPDTSSPG X +MAPK14 P38A Q16539 human p21Cip1 1026 P38936 CDKN1A human S130 455618 sGEQAEGsPGGPGDs X X +MAPK14 P38A Q16539 human TAB1 10454 Q15750 TAB1 human S423 456222 QMVNGAHsASTLDEA X X +MAPK14 P38A Q16539 human KARS 3735 Q15046 KARS1 human T52 25692907 EKQLsQAtAAATNHT X X +MAPK14 P38A Q16539 human PIP4K2B 8396 P78356 PIP4K2B human S326 470107 SYGtPPDsPGNLLsF PIP5K X X +MAPK14 P38A Q16539 human SCS-beta 8803 Q9P2R7 SUCLA2 human S79 27457818 PKGyVAksPDEAyAI ATP-grasp_2 X X +MAPK14 P38A Q16539 human 4E-BP1 13685 Q60876 Eif4ebp1 mouse T36 447497 PPGDysttPGGtLFs eIF_4EBP X X 2855; 9459; 2846; 4923; 5123; 3929; 7547; 45613; 39788 +MAPK14 P38A Q16539 human FOXN3 1112 O00409 FOXN3 human S83 4930951 FGESVLRsVsPVQDL X X +MAPK14 P38A Q16539 human Kv2.1 3745 Q14721 KCNB1 human S800 473567 EKNHFESsPLPtsPK X +MAPK14 P38A Q16539 human p63 8626 Q9H3D4 TP63 human S395 451602 TSIKKRRsPDDELLY P53_tetramer X +MAPK14 P38A Q16539 human NHE1 6548 P19634 SLC9A1 human S723 2509103 VItIDPAsPQsPEsV X +MAPK14 P38A Q16539 human HSP27 3315 P04792 HSPB1 human S176 26352800 MPkLAtQsNEItIPV HSP20 X +MAPK14 P38A Q16539 human ER-alpha 2099 P03372 ESR1 human S118 448101 LHPPPQLsPFLQPHG Oest_recep X 2511 +MAPK14 P38A Q16539 human PXN 360820 Q66H76 Pxn rat S83 451113 yAHQQPPsPSPIySS Paxillin X +MAPK14 P38A Q16539 human SNX27 81609 Q96L92 SNX27 human S51 486072 VRIVksEsGYGFNVR PDZ X X +MAPK14 P38A Q16539 human MAPKAPK5 17165 O54992 Mapkapk5 mouse T182 450093 VDQGDLMtPQFTPYY Pkinase X +MAPK14 P38A Q16539 human MKL1 57591 Q969V6 MRTFA human S333 3208578 CGLARQNstsLtGKP X +MAPK14 P38A Q16539 human osterix 170574 Q8VI67 Sp7 mouse S77 15334101 GLLsPAGsPPAPASG X X +MAPK14 P38A Q16539 human AGO2 27161 Q9UKV8 AGO2 human S387 472450 SkLMRsAsFNtDPyV ArgoL2 X +MAPK14 P38A Q16539 human MED17 234959 Q8VCD5 Med17 mouse T568 63083901 IGNASAItVASPSGD X +MAPK14 P38A Q16539 human p47phox 653361 P14598 NCF1 human S345 451727 QARPGPQsPGsPLEE X X +MAPK14 P38A Q16539 human GSK3B 2932 P49841 GSK3B human T390 452320 RIQAAAstPtNAtAA X X 3548 +MAPK14 P38A Q16539 human FOXN3 1112 O00409 FOXN3 human S85 454694 ESVLRsVsPVQDLDD X X +MAPK14 P38A Q16539 human TBX2 21385 Q60707 Tbx2 mouse S675 1308916 GPsRGALsPSGsAKE X X +MAPK14 P38A Q16539 human Mnk1 8569 Q9BUB5 MKNK1 human T255 447622 ITtPELTtPCGSAEY Pkinase X 2111; 43507 +MAPK14 P38A Q16539 human ER-alpha 2099 P03372 ESR1 human S294 451560 RAANLWPsPLMIkRS X X +MAPK14 P38A Q16539 human NHE1 6548 P19634 SLC9A1 human S729 3181649 AsPQsPEsVDLVNEE X X +MAPK14 P38A Q16539 human DROSHA 29102 Q9NRR4 DROSHA human S221 23100760 KAPSERRsPERLKHy X X +MAPK14 P38A Q16539 human BIM 64547 O88498 Bcl2l11 rat S65 449330 GPLAPPAsPGPFATR X X 4581; 4585 +MAPK14 P38A Q16539 human SRC-3 8202 Q9Y6Q9 NCOA3 human S867 454107 sPVsVGssPPVKNIS X +MAPK14 P38A Q16539 human MSK1 73086 Q8C050 Rps6ka5 mouse T764 471413 LssNPLMtPDILGSS X +MAPK14 P38A Q16539 human LIMK1 3984 P53667 LIMK1 human S310 459629 PGAGsLGsPAsQRKD X +MAPK14 P38A Q16539 human TWIST1 7291 Q15672 TWIST1 human S68 18905000 GGGDEPGsPAQGkRG X X +MAPK14 P38A Q16539 human MEF2A 4205 Q02078 MEF2A human T312 448097 QATQPLAtPVVSVTt X +MAPK14 P38A Q16539 human MAPKAPK2 9261 P49137 MAPKAPK2 human T222 448269 tSHNsLttPCytPYY Pkinase X X 3316 +MAPK14 P38A Q16539 human RORA 19883 P51448 Rora mouse S100 1212279800 CKGFFRRsQQSNATY zf-C4 X +MAPK14 P38A Q16539 human MEF2D 17261 Q63943 Mef2d mouse S190 2246701 QPALQRNsVsPGLPQ X +MAPK14 P38A Q16539 human MSK1 9252 O75582 RPS6KA5 human S360 448215 TEMDPTYsPAALPQS Pkinase_C X 9594 +MAPK14 P38A Q16539 human MAOA 4128 P21397 MAOA human S209 9726600 GGTTRIFsVTNGGQE Amino_oxidase X +MAPK14 P38A Q16539 human ZAP70 7535 P43403 ZAP70 human T293 478058 tLNsDGytPEPARIt X X +MAPK14 P38A Q16539 human HePTP 5778 P35236 PTPN7 human T66 448311 EPICsVNtPREVTLH X +MAPK14 P38A Q16539 human HSF1 3297 Q00613 HSF1 human S307 449046 EPPsPPQsPRVEEAs Vert_HS_TF X +MAPK14 P38A Q16539 human p57Kip2 iso2 12577 P49919-2 Cdkn1c mouse T143 25525402 AEPTPPAtPAPASDL X X +MAPK14 P38A Q16539 human RCAN1 54720 Q9JHG6 Rcan1 mouse S146 25687504 AQTLHIGsSHLAPPN Calcipressin X +MAPK14 P38A Q16539 human BTG2 12227 Q04211 Btg2 mouse S149 1709500 MLGRSsPsKNYVMAV X +MAPK14 P38A Q16539 human DROSHA 29102 Q9NRR4 DROSHA human S355 30985044 LEIVNHRsPsREKKR X X +MAPK14 P38A Q16539 human TAB1 10454 Q15750 TAB1 human S457 22869800 TQssSSssDGGLFRS X X +MAPK14 P38A Q16539 human MEF2A 4205 Q02078 MEF2A human S479 4957257 DPRGDFHsPIVLGRP X +MAPK14 P38A Q16539 human PAK6 56924 Q9NQU5 PAK6 human S165 454427 MPWPEPQsPRVLPNG X +MAPK14 P38A Q16539 human EGFR 1956 P00533 EGFR human S1039 3178884 tPLLSsLsAtsNNst X +MAPK14 P38A Q16539 human MEF2C iso3 4208 Q06413-3 MEF2C human S387 1729600 TRHEAGRsPVDSLSS X +MAPK14 P38A Q16539 human CASP3 836 P42574 CASP3 human S150 450984 FRGDRCRsLtGKPKL Peptidase_C14 X X +MAPK14 P38A Q16539 human Stargazin 84347 Q71RJ2 Cacng2 rat T321 451273 NTANRRTtPV_____ X +MAPK14 P38A Q16539 human NFAT3 73181 Q8K120 Nfatc4 mouse S170 448860 GGAFFsPsPGSSSLS X +MAPK14 P38A Q16539 human ER-alpha 2099 P03372 ESR1 human T311 449929 NsLALSLtADQMVSA X X +MAPK14 P38A Q16539 human Tau iso8 4137 P10636-8 MAPT human T181 447932 ktPPAPktPPssGEP X 12885; 66224; 62672 +MAPK14 P38A Q16539 human coronin 1B 57175 Q9BR76 CORO1B human S2 456131 ______MsFRKVVRQ X X +MAPK14 P38A Q16539 human TBX2 21385 Q60707 Tbx2 mouse S623 1308917 ArPrLRFsPYQIPVT X X +MAPK14 P38A Q16539 human DLX5 13395 P70396 Dlx5 mouse S34 1725302 MHHPSQEsPTLPESS DLL_N X X +MAPK14 P38A Q16539 human P38A 26416 P47811 Mapk14 mouse Y182 447971 tDDEMtGyVAtRWYR Pkinase X 9211; 9215; 4551; 9216; 4552; 4631; 4511; 4092; 9219; 24678; 8632; 6908; 41768; 51255; 14594; 14598; 62979 +MAPK14 P38A Q16539 human EGFR 1956 P00533 EGFR human T693 448054 RELVEPLtPsGEAPN X 3056; 8808 +MAPK14 P38A Q16539 human Mnk1 iso2 8569 Q9BUB5-2 MKNK1 human T209 447621 NSCTPITtPELTtPC Pkinase X 2111; 43507 +MAPK14 P38A Q16539 human Rb 5925 P06400 RB1 human S838 14160962 ILVsIGEsFGtsEkF Rb_C X X +MAPK14 P38A Q16539 human MAPKAPK5 8550 Q8IW41 MAPKAPK5 human T182 450093 IDQGDLMtPQFtPyY Pkinase X +MAPK14 P38A Q16539 human MEF2D 17261 Q63943 Mef2d mouse S121 2246700 EDKYRRAsEELDGLF HJURP_C X +MAPK14 P38A Q16539 human STMN1 29332 P13668 Stmn1 rat S25 448555 QAFELILsPRSKESV Stathmin X +MAPK14 P38A Q16539 human GSK3B 2932 P49841 GSK3B human S389 454221 ARIQAAAstPtNAtA X +MAPK14 P38A Q16539 human ATF-2 11909 P16951 Atf2 mouse T53 448225 IVADQtPtPtRFLKN X X 9225; 9221; 5112; 94125; 13850; 40749; 15411; 24329; 61584; 27934; 92109; 20534; 35858 +MAPK14 P38A Q16539 human FOXO3A 2309 O43524 FOXO3 human S344 2058401 QDDDAPLsPMLYSSS X +MAPK14 P38A Q16539 human ELK4 2005 P28324 ELK4 human S381 4317600 IHFWSTLsPVAPLsP X X +MAPK14 P38A Q16539 human XBP1 22433 O35426 Xbp1 mouse T48 21688103 AGSEASGtPQARKRQ X +MAPK14 P38A Q16539 human MZF-1 109889 O70162 Mzf1 mouse S354 448855 TAEPDMMsPHLHVPW X +MAPK14 P38A Q16539 human NALP1 22861 Q9C000 NLRP1 human S107 1880261804 PSEPHLGsPSQPTST X +MAPK14 P38A Q16539 human GJA1 2697 P17302 GJA1 human S279 448853 sSPtAPLsPMsPPGy X +MAPK14 P38A Q16539 human HSF1 3297 Q00613 HSF1 human S303 449045 RVkEEPPsPPQsPRV Vert_HS_TF X +MAPK14 P38A Q16539 human CDT1 81620 Q9H211 CDT1 human S491 21440505 GSCCTIMsPGEMEKH CDT1_C X X +MAPK14 P38A Q16539 human Tip60 iso2 10524 Q92993-2 KAT5 human T106 10800707 VEVVsPAtPVPSETA X +MAPK14 P38A Q16539 human SHC1 20416 P98083 Shc1 mouse S36 448508 TPPEELPsPSASSLG X +MAPK14 P38A Q16539 human MAFA 389692 Q8NHW3 MAFA human T134 456029 NPEALNLtPEDAVEA Maf_N X +MAPK14 P38A Q16539 human MEF2A 4205 Q02078 MEF2A human T108 485622 PDtsyVLtPHtEEKy HJURP_C X +MAPK14 P38A Q16539 human HNF4 alpha 3172 P41235 HNF4A human S167 458371 VLSRQItsPVsGING X X +MAPK14 P38A Q16539 human SCN8A 20273 Q9WTU3 Scn8a mouse S553 456209 SLLSIPGsPFLSRHN Na_trans_cytopl X +MAPK14 P38A Q16539 human GSK3B 56637 Q9WV60 Gsk3b mouse S389 454221 ARIQAAAsPPANAtA X +MAPK14 P38A Q16539 human PARK2 5071 O60260 PRKN human S131 454421 HTDsRkDsPPAGsPA X +MAPK14 P38A Q16539 human MDM4 4194 O15151 MDM4 human S314 62381100 TECKKFNsPSKRYCF zf-RanBP X +MAPK14 P38A Q16539 human NFAT2 4772 O95644 NFATC1 human S172 465577 YRDPsCLsPASSLSS X +MAPK14 P38A Q16539 human RCAN1 54720 Q9JHG6 Rcan1 mouse S165 456023 FLIsPPAsPPVGWKQ Calcipressin X +MAPK14 P38A Q16539 human PDX1 3651 P52945 PDX1 human S61 458401 LGALEQGsPPDIsPY X +MAPK14 P38A Q16539 human EEA1 8411 Q15075 EEA1 human T1392 456871 CSAKNALtPSSKKPV FYVE X X +MAPK14 P38A Q16539 human TIF1B 10155 Q13263 TRIM28 human S473 452391 sGVkRsRsGEGEVsG X +MAPK14 P38A Q16539 human F3 2152 P13726 F3 human S290 451613 GQsWkENsPLNVs__ X X +MAPK14 P38A Q16539 human MSK2 8986 O75676 RPS6KA4 human S196 450046 EEkERtFsFCGTIEY Pkinase X +MAPK14 P38A Q16539 human GJA1 2697 P17302 GJA1 human S282 448854 tAPLsPMsPPGykLV X +MAPK14 P38A Q16539 human CRYAB 12955 P23927 Cryab mouse S59 448783 PSFLRAPsWIDtGLS X +MAPK14 P38A Q16539 human TAB1 10454 Q15750 TAB1 human S453 22869803 TNTHTQssSSssDGG X X +MAPK14 P38A Q16539 human MAPKAPK2 9261 P49137 MAPKAPK2 human T25 448271 APPPQPPtPALPHPP X +MAPK14 P38A Q16539 human MKL1 223701 Q8K4J6 Mrtfa mouse S487 4762839 VKFGsTGstPPVsPT X +MAPK14 P38A Q16539 human MEF2D 4209 Q14814 MEF2D human S231 3196574 GYVsARAsPGLLPVA X +MAPK14 P38A Q16539 human E2F4 E1BUH4 E2F4 chicken T261 25571901 PSSTQPStPtPSSTQ X +MAPK14 P38A Q16539 human HSF1 3297 Q00613 HSF1 human S326 455484 ssVDtLLsPTALIDs Vert_HS_TF X X +MAPK14 P38A Q16539 human TAB1 10454 Q15750 TAB1 human S438 456224 tPTLTNQsPTLtLQS X X +MAPK14 P38A Q16539 human MAPKAPK2 9261 P49137 MAPKAPK2 human T334 448273 QstKVPQtPLHtsRV X X 3007; 3041 +MAPK14 P38A Q16539 human MSK1 9252 O75582 RPS6KA5 human T581 448217 PDNQPLKtPCFTLHY Pkinase X 9595 +MAPK14 P38A Q16539 human IFNAR1 3454 P17181 IFNAR1 human S532 11927800 KKySSQTsQDsGNys X X +MAPK14 P38A Q16539 human MKL1 57591 Q969V6 MRTFA human S312 10989194 tPPVRsLstTNSsSS X +MAPK14 P38A Q16539 human TFEB 21425 Q9R210 Tfeb mouse S400 1880515602 LDFSHGLsFGGGGDE X X +MAPK14 P38A Q16539 human NOXA1 10811 Q86UR1 NOXA1 human S282 12570900 VGKQAPLsPGLPAMG X X +MAPK14 P38A Q16539 human Bcl-2 596 P10415 BCL2 human T56 448655 FSSQPGHtPHPAASR X X 2875 +MAPK14 P38A Q16539 human CCND2 894 P30279 CCND2 human T280 469202 DELDQAstPtDVRDI Cyclin_C X X +MAPK14 P38A Q16539 human LAMP2 3920 P13473 LAMP2 human T211 386186605 tVPSPtttPtPKEKP X X +MAPK14 P38A Q16539 human MEF2D 4209 Q14814 MEF2D human S450 27452873 VsPsRERsPAPPPPA X +MAPK14 P38A Q16539 human ELK1 2002 P19419 ELK1 human S383 447872 IHFWSTLsPIAPRsP X X 9181; 9186 +MAPK14 P38A Q16539 human p53 7157 P04637 TP53 human S15 447490 PsVEPPLsQEtFsDL P53_TAD X X 4030; 9235; 9284; 9286; 8695; 8514; 82530; 56979 +MAPK14 P38A Q16539 human TRIM9 iso5 114088 Q9C026-5 TRIM9 human S76 1046182900 SLYSEADsGYGsYGG X +MAPK14 P38A Q16539 human ZFYVE20 64145 Q9H1K0 RBSN human S215 457605 EsLSTHtsPsQsPNs FYVE X X +MAPK14 P38A Q16539 human PKCE 5581 Q02156 PRKCE human S350 486055 RsKsAPtsPCDQEIK X +MAPK14 P38A Q16539 human F3 2152 P13726 F3 human S285 451611 RKAGVGQsWkENsPL X +MAPK14 P38A Q16539 human RCAN1 54720 Q9JHG6 Rcan1 mouse S161 456022 PDKQFLIsPPAsPPV Calcipressin X +MAPK14 P38A Q16539 human Oct7 5454 P20265 POU3F2 human S91 1868139200 GGGGGDGsPWSTSPL X +MAPK14 P38A Q16539 human FOXC1 2296 Q12948 FOXC1 human S272 460580 SSLSSGSsPPGSLPS X +MAPK14 P38A Q16539 human MFF 56947 Q9GZY8 MFF human S155 470753 GRLkRERsMsENAVR Miff X X +MAPK14 P38A Q16539 human TAO2 iso2 64666 Q9JLS3-2 tao2 rat S1038 1308925 AAVPGPLsRSTSVAS X +MAPK14 P38A Q16539 human EZH2 2146 Q15910 EZH2 human T367 466987 NNssRPstPtINVLE X X +MAPK14 P38A Q16539 human Tau iso8 4137 P10636-8 MAPT human T205 447933 ssPGsPGtPGsRsRt X X 25377; 43964; 53001; 49561; 20060; 33032; 30505; 20739; 98160 +MAPK14 P38A Q16539 human SREBP-1 iso3 6720 P36956-3 SREBF1 human T402 467200 TEVEDTLtPPPSDAG X +MAPK14 P38A Q16539 human NFAT3 73181 Q8K120 Nfatc4 mouse S168 448859 QGGGAFFsPsPGSSS X +MAPK14 P38A Q16539 human SOX2 20674 P48432 Sox2 mouse S253 6738002 VksEASSsPPVVtSS X 92186 +MAPK14 P38A Q16539 human Kv7.2 iso4 3785 O43526-4 KCNQ2 human S427 15721018 VAAKGKGsPQAQTVR X +MAPK14 P38A Q16539 human MSK1 73086 Q8C050 Rps6ka5 mouse T645 448217 PDNQPLKtPCFTLHY Pkinase X 9595 +MAPK14 P38A Q16539 human EWS 2130 Q01844 EWSR1 human T79 7359501 QPPTGYTtPTAPQAY X X +MAPK14 P38A Q16539 human PGC-1 alpha 10891 Q9UBK2 PPARGC1A human S266 448008 SLPLtPEsPNDPKGs X X +MAPK14 P38A Q16539 human BACE 23621 P56817 BACE1 human S83 55367300 YVEMTVGsPPQTLNI Asp X +MAPK14 P38A Q16539 human CDT1 81620 Q9H211 CDT1 human T406 21440503 LPAtPPAtPPAAsPs X X +MAPK14 P38A Q16539 human Tau iso8 4137 P10636-8 MAPT human S422 449083 GsIDMVDsPQLAtLA X X +MAPK14 P38A Q16539 human SCN10A Q62968 Scn10a rat S551 2482300 QTGPLPRsPLPQsPN X X +MAPK14 P38A Q16539 human p21Cip1 1026 P38936 CDKN1A human T57 451222 NFDFVtEtPLEGDFA CDI X +MAPK14 P38A Q16539 human HuR 1994 Q15717 ELAVL1 human S88 474552 LNGLRLQskTIkVSY RRM_1 X +MAPK14 P38A Q16539 human eIF2-alpha 1965 P05198 EIF2S1 human S52 447635 MILLsELsRRRIRsI S1 X 3597; 9721; 3398; 5199; 53085; 95797 +MAPK14 P38A Q16539 human Tip60 10524 Q92993 KAT5 human T158 10800707 VEVVsPAtPVPSETA X +MAPK14 P38A Q16539 human AML3 iso5 12393 Q08775-5 Runx2 mouse S319 10892802 SYLSQMTsPSIHSTt X +MAPK14 P38A Q16539 human SRC-3 8202 Q9Y6Q9 NCOA3 human S505 454109 SPVAGVHsPMAsSGN NCOA_u2 X +MAPK14 P38A Q16539 human GR 2908 P04150 NR3C1 human S211 447968 PGkEtNEsPWRSDLL GCR X X 4161 +MAPK14 P38A Q16539 human MAP4 4134 P27816 MAP4 human S787 448480 KAPEkRAsPsKPAsA X +MAPK14 P38A Q16539 human TXNIP 10628 Q9H3M7 TXNIP human S361 3212304 DMDGsQDsPIFMYAP X +MAPK14 P38A Q16539 human MEF2A 4205 Q02078 MEF2A human S494 4728294 PNTEDREsPsVKRMR X +MAPK14 P38A Q16539 human AML3 12393 Q08775 Runx2 mouse S107 3053615 PSTSRRFsPPSssLQ X +MAPK14 P38A Q16539 human MAP4 17758 P27546 Map4 mouse S760 448480 KVAEKRtsPsKPssA X +MAPK14 P38A Q16539 human STAT1 20846 P42225 Stat1 mouse S727 447753 tDNLLPMsPEEFDEM STAT1_TAZ2bind X X 9177; 8826; 62390 +MAPK14 P38A Q16539 human SMARCD3 66993 Q6P9Z1 Smarcd3 mouse T229 8097074 HLVEWHRtPTTQETD X +MAPK14 P38A Q16539 human MEF2C iso3 4208 Q06413-3 MEF2C human T293 448000 QSAQSLAtPVVSVAt X +MAPK14 P38A Q16539 human p63 8626 Q9H3D4 TP63 human S455 451603 QKQtSIQsPSSYGNs X +Akt3 Akt3 Q9WUA6 mouse DAPK2 13143 Q8VDF3 Dapk2 mouse T369 487231 HPRRRssts______ X +Dapk1 DAPK1 F1LNN8 rat NMDAR2B 24410 Q00960 Grin2b rat S1303 450171 NKLRRQHsyDtFVDL NMDAR2_C X 20274; 71335 +PIK3CA PIK3CA P32871 cow PIK3R1 282307 P23727 PIK3R1 cow S608 448133 ENTEDQYsLVEDDED X +AAK1 AAK1 Q2M2I8 human AP2M1 1173 Q96CW1 AP2M1 human T156 448782 SQItsQVtGQIGWRR X 3843; 7399 +AAK1 AAK1 Q2M2I8 human AP2M1 11773 P84091 Ap2m1 mouse T156 448782 SQITsQVtGQIGWRR X 3843; 7399 +AAK1 AAK1 Q2M2I8 human NUMB 8650 P49757 NUMB human T102 3333403 LRVVDEKtKDLIVDQ PID X X +FES Fes P07332 human Fes 2242 P07332 FES human Y811 448354 RPSFSTIyQELQSIR PK_Tyr_Ser-Thr X X +FES Fes P07332 human Bcr 613 P11274 BCR human Y246 447793 sCGVDGDyEDAELNP X +FES Fes P07332 human PECAM-1 18613 Q08481 Pecam1 mouse Y717 465455 PNLMENRysRTEGSL X +FES Fes P07332 human Fes 2242 P07332 FES human Y713 448353 REEADGVyAAsGGLR PK_Tyr_Ser-Thr X X +FES Fes P07332 human CRMP-2 25416 P47942 Dpysl2 rat Y32 463168 VNDDQSFyADIYMED X +FES Fes P07332 human NSF 4905 P46459 NSF human Y83 453414 QEIEVSLyTFDKAKQ CDC48_N X +WNK4 WNK4 Q96J92 human Claudin-7 1366 O95471 CLDN7 human S206 486329 RsYPksNsskEyV__ X +WNK4 WNK4 Q96J92 human STLK3 53416 Q9Z1W9 Stk39 mouse S382 1984125 KVRRVPGssGHLHKT X +WNK4 WNK4 Q96J92 human NCCT 6559 P55017 SLC12A3 human T50 4709842 SHLtHSStFCMRtFG AA_permease_N X +WNK4 WNK4 Q96J92 human NCCT 20497 P59158 Slc12a3 mouse T48 4709842 sHLtHGstLyMRtFG AA_permease_N X +WNK4 WNK4 Q96J92 human WNK4 65266 Q96J92 WNK4 human S335 456207 kRAsFAKsVIGTPEF Pkinase X +WNK4 WNK4 Q96J92 human NCCT 6559 P55017 SLC12A3 human T46 2286406 SSHPSHLtHSStFCM AA_permease_N X +WNK4 WNK4 Q96J92 human NCCT 6559 P55017 SLC12A3 human T55 469616 SStFCMRtFGYNtID AA_permease_N X +SRC Src P00523 chicken CACNA1B 374169 Q9PUM6 CACNA1B chicken Y815 454440 DPEERVRyATTLHIR X +SRC Src P00523 chicken P130Cas 25414 Q63767 Bcar1 rat Y485 451539 RPGPGTLyDVPRERV X +SRC Src P00523 chicken FAK 396416 Q00944 PTK2 chicken Y926 447966 DRSNDKVyENVTGLV Focal_AT X X 3284 +SRC Src P00523 chicken P130Cas iso2 25414 Q63767-2 Bcar1 rat Y169 448722 PSPATDLyQVPPGPG X +SRC Src P00523 chicken RAF1 396245 P05625 RAF1 chicken Y340 447749 RGQRDssyyWEIEAS X +SRC Src P00523 chicken P130Cas iso2 25414 Q63767-2 Bcar1 rat Y132 448778 SKTQQGLyQAPGPNP X +SRC Src P00523 chicken TRPC3 7222 Q13507 TRPC3 human Y299 458805 KGLASPAyLSLSSED X +SRC Src P00523 chicken P130Cas 25414 Q63767 Bcar1 rat Y347 448721 APGSQDIyDVPPVRG X 4014 +SRC Src P00523 chicken PXN 395832 P49024 PXN chicken Y40 449965 YPTGNHTyQEIAVPP X +SRC Src P00523 chicken CACNA1B 374169 Q9PUM6 CACNA1B chicken Y804 454439 RASCEALyNELDPEE X +SRC Src P00523 chicken FAK 396416 Q00944 PTK2 chicken Y576 447889 RyMEDSTyyKASKGK PK_Tyr_Ser-Thr X 3281 +SRC Src P00523 chicken DGKA 1606 P23743 DGKA human Y335 486452 ILPPSSIyPSVLASG X +SRC Src P00523 chicken TRPC3 7222 Q13507 TRPC3 human Y221 458803 ELQDDDFyAyDEDGT TRP_2 X +SRC Src P00523 chicken RAF1 396245 P05625 RAF1 chicken Y341 447750 GQRDssyyWEIEASE X +SRC Src P00523 chicken RAF1 5894 P04049 RAF1 human Y341 447750 GQRDssyyWEIEASE X +SRC Src P00523 chicken GRF-1 232906 Q91YM2 Arhgap35 mouse Y1105 448941 RNEEENIysVPHDST RhoGAP_pG1_pG2 X +SRC Src P00523 chicken P130Cas 25414 Q63767 Bcar1 rat Y277 11997200 GSPAQDIyQVPPSAG X +SRC Src P00523 chicken TRPC3 7222 Q13507 TRPC3 human Y122 458802 RFLDAAEyGNIPVVR Ank_2 X +SRC Src P00523 chicken P130Cas iso2 25414 Q63767-2 Bcar1 rat Y414 448720 SVIDDGVyAVPPPAE X +SRC Src P00523 chicken P130Cas 25414 Q63767 Bcar1 rat Y226 448778 SKTQQGLyQAPGPNP X +SRC Src P00523 chicken P130Cas 25414 Q63767 Bcar1 rat Y385 451538 RDPLLDVyDVPPSVE X +SRC Src P00523 chicken P130Cas iso2 25414 Q63767-2 Bcar1 rat Y238 449639 SQAEQDEyDTPRHLL X +SRC Src P00523 chicken P130Cas iso2 25414 Q63767-2 Bcar1 rat Y391 451539 RPGPGTLyDVPRERV X +SRC Src P00523 chicken P130Cas iso2 25414 Q63767-2 Bcar1 rat Y196 6153351 AGTGHDIyQVPPSLD X +SRC Src P00523 chicken PXN 395832 P49024 PXN chicken Y31 448785 FLTEEtPySYPTGNH X +SRC Src P00523 chicken JIP3 iso2 30957 Q9ESN9-2 Mapk8ip3 mouse Y569 450240 YPSVNIHyKSPTAAG X +SRC Src P00523 chicken PXN 395832 P49024 PXN chicken Y88 448909 PQsQsPIysssAKss Paxillin X +SRC Src P00523 chicken P130Cas 25414 Q63767 Bcar1 rat Y404 448779 PSNHHSVyDVPPSVS X +SRC Src P00523 chicken P130Cas 25414 Q63767 Bcar1 rat Y365 451537 NQYGQEVyDTPPMAV X +SRC Src P00523 chicken TRPC3 7222 Q13507 TRPC3 human Y223 458804 QDDDFyAyDEDGTRF TRP_2 X +SRC Src P00523 chicken P130Cas iso2 25414 Q63767-2 Bcar1 rat Y310 448779 PSNHHSVyDVPPSVS X +SRC Src P00523 chicken P130Cas 25414 Q63767 Bcar1 rat Y290 6153351 AGTGHDIyQVPPSLD X +SRC Src P00523 chicken P130Cas iso2 25414 Q63767-2 Bcar1 rat Y183 11997200 GSPAQDIyQVPPSAG X +SRC Src P00523 chicken P130Cas iso2 25414 Q63767-2 Bcar1 rat Y271 451537 NQYGQEVyDTPPMAV X +SRC Src P00523 chicken P130Cas 25414 Q63767 Bcar1 rat Y508 448720 SVIDDGVyAVPPPAE X 4011 +SRC Src P00523 chicken RAF1 5894 P04049 RAF1 human Y340 447749 RGQRDssyyWEIEAS X +SRC Src P00523 chicken P130Cas 25414 Q63767 Bcar1 rat Y332 449639 SQAEQDEyDTPRHLL X +SRC Src P00523 chicken P130Cas iso2 25414 Q63767-2 Bcar1 rat Y253 448721 APGSQDIyDVPPVRG X +SRC Src P00523 chicken JIP3 iso2 30957 Q9ESN9-2 Mapk8ip3 mouse Y663 448671 KNVPVPVyCRPLVEK X +SRC Src P00523 chicken P130Cas iso2 25414 Q63767-2 Bcar1 rat Y291 451538 RDPLLDVyDVPPSVE X +SRC Src P00523 chicken JIP3 iso2 30957 Q9ESN9-2 Mapk8ip3 mouse Y616 448670 REQKREQyRQVREHV X +SRC Src P00523 chicken Kv2.1 25736 P15387 Kcnb1 rat Y128 449085 YWGIDEIyLESCCQA BTB_2 X +SRC Src P00523 chicken Src 396442 P00523 SRC chicken Y416 448234 RLIEDNEyTARQGAK PK_Tyr_Ser-Thr X 2101; 59548; 70926; 78740; 94361; 17320 +SRC Src P00523 chicken CDK1 983 P06493 CDK1 human Y15 447610 EkIGEGtyGVVykGR Pkinase X 4539; 9111; 14566; 77897 +SRC Src P00523 chicken Lasp-1 3927 Q14847 LASP1 human Y171 451675 IPtsAPVyQQPQQQP X X +SRC Src P00523 chicken P130Cas 25414 Q63767 Bcar1 rat Y263 448722 PSPATDLyQVPPGPG X 4015 +CHUK IKKA O15111 human SRC-3 8202 Q9Y6Q9 NCOA3 human S857 453084 PPYNRAVsLDsPVsV X +CHUK IKKA O15111 human Nik 9020 Q99558 MAP3K14 human S820 27259015 PsKAsQSsRDTLSSG X +CHUK IKKA O15111 human NFkB-p105 4790 P19838 NFKB1 human S923 447769 DELRDSDsVCDsGVE X +CHUK IKKA O15111 human RORC iso2 19885 P51450-2 Rorc mouse S376 139835702 GCSELISsIFDFSHF Hormone_recep X +CHUK IKKA O15111 human mTOR 2475 P42345 MTOR human S1418 15721416 AILEsLIsINNKLQQ X +CHUK IKKA O15111 human FOXA2 3170 Q9Y261 FOXA2 human S107 22825100 AGMGPHLsPSLsPLG Forkhead_N X X +CHUK IKKA O15111 human p27Kip1 12576 P46414 Cdkn1b mouse T183 23128659 DGsPNAGtVEQtPKK X +CHUK IKKA O15111 human ATG16L1 55054 Q676U5 ATG16L1 human S278 15425208 PAGGLLDsITNIFGR X X 45511; 84300 +CHUK IKKA O15111 human COPS5 10987 Q92905 COPS5 human S201 1827354807 kPPDEGPsEyQtIPL X X +CHUK IKKA O15111 human CTNNB1 1499 P35222 CTNNB1 human S37 447582 yLDsGIHsGATtTAP X 9561; 2009; 4270; 13537; 41334; 60180 +CHUK IKKA O15111 human PIAS1 56469 O88907 Pias1 mouse S90 479880 SPMPPTLsPSTIPQL X +CHUK IKKA O15111 human MTURN 222166 Q8N3F0 MTURN human S58 149319100 GDNFHVWsESEDCLP DUF4581 X +CHUK IKKA O15111 human H3 8350 P68431 H3C1 human S10 455676 tkQtArkstGGkAPr Histone X 9701; 9711; 9606; 3465; 3642; 3377; 3475; 3458; 5764; 47398; 8481; 8552; 53348; 29237; 66065; 43185; 64522; 52725 +CHUK IKKA O15111 human CTNNB1 1499 P35222 CTNNB1 human S45 447488 GATtTAPsLsGkGNP X 9565; 9564; 24710; 70034; 19807; 96727; 77605 +CHUK IKKA O15111 human CBP 1387 Q92793 CREBBP human S1382 478512 MkSRFVDsGEMsESF HAT_KAT11 X X +CHUK IKKA O15111 human mTOR 2475 P42345 MTOR human S1415 25745815 PTPAILEsLIsINNK X X +CHUK IKKA O15111 human NFkB-p65 5970 Q04206 RELA human S536 447800 sGDEDFSsIADMDFS X X 4887; 3036; 3031; 4886; 3033; 4025; 5733; 13346; 76778; 31553; 80477; 73992; 87672; 83962 +CHUK IKKA O15111 human HuR 1994 Q15717 ELAVL1 human S304 27156803 EAAMAIAsLNGYRLG RRM_1 X +CHUK IKKA O15111 human N-CoR1 20185 Q60974 Ncor1 mouse S2348 2888301 NKSNsRKsKsPIPGQ X +CHUK IKKA O15111 human IKKA 12675 Q60680 Chuk mouse S176 447778 AKDVDQGsLCTsFVG Pkinase X 2078; 2697; 14938; 92255; 36516; 36214 +CHUK IKKA O15111 human CCND1 595 P24385 CCND1 human T286 447839 EEVDLACtPtDVRDV X X 3300; 94159 +CHUK IKKA O15111 human Bcl-3 602 P20749 BCL3 human S454 31867760 PsPAPGGs_______ X +CHUK IKKA O15111 human FOXA2 3170 Q9Y261 FOXA2 human S111 22825101 PHLsPSLsPLGGQAA Forkhead_N X X +CHUK IKKA O15111 human NFkB-p100 4791 Q00653 NFKB2 human S870 450167 kEDsAyGsQsVEQEA X X 4810 +CHUK IKKA O15111 human TAX1BP1 iso2 8887 Q86VP1-2 TAX1BP1 human S593 12738639 NYKELKRsLENPAER X +CHUK IKKA O15111 human Myc 4609 P01106 MYC human S82 4967400 PLsPsRRsGLCsPSy Myc_N X X +CHUK IKKA O15111 human COPS5 10987 Q92905 COPS5 human T205 1827354804 EGPsEyQtIPLNkIE X X +CHUK IKKA O15111 human IkB-alpha 4792 P25963 NFKBIA human S32 448203 LLDDRHDsGLDsMkD X X 5210; 2859; 9246; 5209 +CHUK IKKA O15111 human FOXO3A 2309 O43524 FOXO3 human S644 451438 GLDFNFDsLISTQNV FOXO-TAD X +CHUK IKKA O15111 human REL 5966 Q04864 REL human S557 480318 SNTTVFVsQSDAFEG X +CHUK IKKA O15111 human NFkB-p105 4790 P19838 NFKB1 human S927 447770 DSDsVCDsGVETsFR X X +CHUK IKKA O15111 human Myc 4609 P01106 MYC human S86 449991 sRRsGLCsPSyVAVt Myc_N X X +CHUK IKKA O15111 human ER-alpha 2099 P03372 ESR1 human S118 448101 LHPPPQLsPFLQPHG Oest_recep X 2511 +CHUK IKKA O15111 human TRAF4 9618 Q9BUZ4 TRAF4 human S426 3211032 kPGtWRGsLDEsSLG X X +CHUK IKKA O15111 human IkB-alpha 4792 P25963 NFKBIA human S36 448204 RHDsGLDsMkDEEyE X X 5210; 9246 +CHUK IKKA O15111 human NFkB-p100 4791 Q00653 NFKB2 human S872 452185 DsAyGsQsVEQEAEK X X +CHUK IKKA O15111 human RELB 5971 Q01201 RELB human S472 36392502 DFFSGTVsLPGLEPP RelB_transactiv X X +CHUK IKKA O15111 human NFkB-p100 4791 Q00653 NFKB2 human S115 452188 sLVGkQCsELGICAV RHD_DNA_bind X +CHUK IKKA O15111 human DCUN1D5 76863 Q9CXV9 Dcun1d5 mouse S41 9763708 QPPARLIsGEEDFSR X X +CHUK IKKA O15111 human AMBRA1 55626 Q9C0C7 AMBRA1 human S1043 1255792404 CRPEALNsGVEYYWD X X +CHUK IKKA O15111 human DARPP-32 84152 Q9UD71 PPP1R1B human T34 448047 MIrRRRPtPAMLFRL DARPP-32 X X 12438 +CHUK IKKA O15111 human Nik 9020 Q99558 MAP3K14 human S817 27259013 EKNPsKAsQSsRDTL X +CHUK IKKA O15111 human NFkB-p100 4791 Q00653 NFKB2 human S99 452186 EVDLVtHsDPPRAHA RHD_DNA_bind X +CHUK IKKA O15111 human SMRT 9612 Q9Y618 NCOR2 human S2407 454664 AkVSGRPsSRKAKsP X X +CHUK IKKA O15111 human CTNNB1 1499 P35222 CTNNB1 human S33 447487 QQQsyLDsGIHsGAT X 9561; 2009; 4270; 13537; 41334; 60180 +CHUK IKKA O15111 human PUMA 27113 Q9BXH1 BBC3 human S10 18610000 RARQEGSsPEPVEGL PUMA X +CHUK IKKA O15111 human HSC70 15481 P63017 Hspa8 mouse S85 31857927 FDDAVVQsDMkHWPF HSP70 X X +CHUK IKKA O15111 human Nik 9020 Q99558 MAP3K14 human S814 27259014 DDSEKNPsKAsQSsR X +CHUK IKKA O15111 human CBP 1387 Q92793 CREBBP human S1386 478513 FVDsGEMsESFPyRT HAT_KAT11 X X +CHUK IKKA O15111 human TAX1BP1 iso2 8887 Q86VP1-2 TAX1BP1 human S624 468908 RPPVRVPsWGLEDNV X +CHUK IKKA O15111 human NFkB-p100 4791 Q00653 NFKB2 human S123 452189 ELGICAVsVGPKDMT RHD_DNA_bind X +CHUK IKKA O15111 human N-CoR1 20185 Q60974 Ncor1 mouse S2345 2888300 KLINKSNsRKsKsPI X +CHUK IKKA O15111 human CTNNB1 1499 P35222 CTNNB1 human T41 447583 GIHsGATtTAPsLsG X 9561; 9565; 4270; 13537; 41334; 60180 +CHUK IKKA O15111 human NFkB-p65 19697 Q04207 Rela mouse S534 447800 sGDEDFssIADMDFS X X 4887; 3036; 3031; 4886; 3033; 4025; 5733; 13346; 76778; 31553; 80477; 73992; 87672; 83962 +CHUK IKKA O15111 human PIK3R1 18708 P26450 Pik3r1 mouse S690 25018700 EPYNLYSsLKELVLH SH2 X X +CHUK IKKA O15111 human NFkB-p105 4790 P19838 NFKB1 human S932 447771 CDsGVETsFRKLsFt X X 4806; 4808; 41317 +CHUK IKKA O15111 human NFkB-p100 4791 Q00653 NFKB2 human S108 452187 PPRAHAHsLVGkQCs RHD_DNA_bind X +CHUK IKKA O15111 human NFkB-p100 4791 Q00653 NFKB2 human S866 450166 tAEVkEDsAyGsQsV X X 4810 +CDK2 CDK2 P24941 human SNAPIN 23557 O95295 SNAPIN human S133 476022 sGIyPPGsPGk____ X +CDK2 CDK2 P24941 human Rb-like 2 5934 Q08999 RBL2 human S639 449726 DEICIAGsPLtPRRV X +CDK2 CDK2 P24941 human Tau iso8 4137 P10636-8 MAPT human T231 449079 KKVAVVRtPPKsPss X 20473; 71429 +CDK2 CDK2 P24941 human CP110 9738 O43303 CCP110 human S45 35546003 FHGVAILsPLLNIEK CaM_bind X X +CDK2 CDK2 P24941 human MED1 5469 Q15648 MED1 human S1207 3197141 GGSDKLAsPMkPVPG X +CDK2 CDK2 P24941 human BTG1 694 P62324 BTG1 human S159 457381 ELLLGRTsPSKNYNM X +CDK2 CDK2 P24941 human NCL 4691 P19338 NCL human T121 470366 PGkALVAtPGkkGAA X +CDK2 CDK2 P24941 human EEF2 1938 P13639 EEF2 human T435 3180609 rIMGPNytPGkkEDL GTP_EFTU_D2 X +CDK2 CDK2 P24941 human TIF1A 54700 Q9NYV6 RRN3 human S44 470000 LENDFFNsPPRKTVR X +CDK2 CDK2 P24941 human Rb 5925 P06400 RB1 human S780 447978 strPPtLsPIPHIPr Rb_C X 9307; 3590; 8180 +CDK2 CDK2 P24941 human MCM3 4172 P25205 MCM3 human T722 449197 EEMPQVHtPKtADsQ X +CDK2 CDK2 P24941 human ANKRD17 26057 O75179 ANKRD17 human S2401 3177630 SSGVRAPsPAPSSVP X +CDK2 CDK2 P24941 human RBM10 8241 P98175 RBM10 human S89 4033099 RRRRHRHsPtGPPGF X +CDK2 CDK2 P24941 human Chk1 1111 O14757 CHEK1 human S286 465527 tsGGVsEsPsGFskH X +CDK2 CDK2 P24941 human MKL1 57591 Q969V6 MRTFA human T573 31933500 PAPAPLGtPVkQENS X +CDK2 CDK2 P24941 human MyoD 17927 P10085 Myod1 mouse S200 40684505 SGDSDASsPRsNCSD Myf5 X +CDK2 CDK2 P24941 human H1E 3008 P10412 H1-4 human T146 458356 KkATGAAtPkKSAKK X +CDK2 CDK2 P24941 human ELF4 2000 Q99607 ELF4 human T643 463813 SLLTRsPtPAPFsPF X +CDK2 CDK2 P24941 human DYN2 1785 P50570 DNM2 human S764 3191449 LQsAssHsPtPQRRP X +CDK2 CDK2 P24941 human SRC-1 8648 Q15788 NCOA1 human S325 18958505 MTRGTASsPSYRFIL PAS_11 X +CDK2 CDK2 P24941 human GATA3 2625 P23771 GATA3 human T156 33638003 HLFTFPPtPPKDVsP X X +CDK2 CDK2 P24941 human POLL 27343 Q9UGP5 POLL human S177 4781554 PPPtRPVsPPQKAKE X +CDK2 CDK2 P24941 human ELK4 2005 P28324 ELK4 human S387 4317601 LsPVAPLsPARLQGA X X +CDK2 CDK2 P24941 human FOXO1A 2308 Q12778 FOXO1 human S249 471071 EGGkSGksPrRrAAs X X +CDK2 CDK2 P24941 human PPP1CA 5499 P62136 PPP1CA human T320 448686 NPGGRPItPPRNsAK X X 2581 +CDK2 CDK2 P24941 human PTHrP 5744 P12272 PTHLH human T121 449879 YKEQPLKtPGKKKKG Parathyroid X X +CDK2 CDK2 P24941 human CDC6 990 Q99741 CDC6 human S106 450916 DNQLTIksPSkRELA X X +CDK2 CDK2 P24941 human NRF1 4899 Q16656 NRF1 human S102 1868914505 HVFEsNPsIRKRQQT Nrf1_DNA-bind X +CDK2 CDK2 P24941 human PKAR1A 5573 P10644 PRKAR1A human S83 450936 DsREDEIsPPPPNPV X +CDK2 CDK2 P24941 human DRP1 74006 Q8K1M6 Dnm1l mouse S622 454690 PIPIMPAsPQKGHAV X 3455; 4494; 63940 +CDK2 CDK2 P24941 human SRC-1 8648 Q15788 NCOA1 human S22 4711609 DSHKRKGsPCDtLAS X +CDK2 CDK2 P24941 human RAD54L 8438 Q92698 RAD54L human S49 31855101 QIQECFLsPFRkPLS X +CDK2 CDK2 P24941 human SRC-1 8648 Q15788 NCOA1 human S488 18958503 ISLAQFMsPRRQVTS NCOA_u2 X +CDK2 CDK2 P24941 human CDC25A 993 P30304 CDC25A human S283 58934700 PErsQEEsPPGSTKr M-inducer_phosp X X +CDK2 CDK2 P24941 human TTK 7272 P33981 TTK human T468 471488 DyMsCFrtPVVkNDF X +CDK2 CDK2 P24941 human NPM1 18148 Q61937 Npm1 mouse T198 448515 VKKsVRdtPAKNAQK X 3541; 75984 +CDK2 CDK2 P24941 human TBCE 6905 Q15813 TBCE human S495 3197270 DLLLSYEsPKKPGRE Ubiquitin_2 X +CDK2 CDK2 P24941 human PARP10 84875 Q53GL7 PARP10 human T101 12526705 QGLPPGTtPQRLEQH X +CDK2 CDK2 P24941 human p73 7161 O15350 TP73 human T86 449047 AASASPYtPEHAASV X X +CDK2 CDK2 P24941 human CDT1 81620 Q9H211 CDT1 human S31 455585 kLACRtPsPARPALR X +CDK2 CDK2 P24941 human TK 7083 P04183 TK1 human S13 448816 LPtVLPGsPskTRGQ X +CDK2 CDK2 P24941 human FAM168B 130074 A1KXE4 FAM168B human T57 9831677 QTGYTPGtPYKVSCS TCRP1 X +CDK2 CDK2 P24941 human MTA1 9112 Q13330 MTA1 human S522 3195323 RLPEAsQsPLVLkQA MTA_R1 X +CDK2 CDK2 P24941 human SRC-1 8648 Q15788 NCOA1 human T1179 449063 NYGTNPGtPPASTsP DUF1518 X +CDK2 CDK2 P24941 human ER-alpha 2099 P03372 ESR1 human S104 448099 FPPLNsVsPsPLMLL Oest_recep X +CDK2 CDK2 P24941 human FAM122A 116224 Q96E09 PABIR1 human S143 467589 RIDFIPVsPAPsPtR X +CDK2 CDK2 P24941 human CC2D1A 54862 Q6P1N0 CC2D1A human S208 483763 PAstPtysPAPtQPA X +CDK2 CDK2 P24941 human AKIRIN2 55122 Q53H80 AKIRIN2 human S21 485532 DPLLsPAsPKRRRCA X +CDK2 CDK2 P24941 human CTNNB1 84353 Q9WU82 Ctnnb1 rat S45 447488 GATtTAPsLSGkGNP X 9565; 24710; 70034; 19807; 96727; 77605 +CDK2 CDK2 P24941 human B-Myb 17865 P48972 Mybl2 mouse T447 452026 NSLtPKStPVkTLPF X +CDK2 CDK2 P24941 human FOXK2 3607 Q01167 FOXK2 human S373 3193955 sSRsAPAsPNHAGVL X +CDK2 CDK2 P24941 human FBXL11 22992 Q9Y2K7 KDM2A human T550 469788 MKPAPRLtPVRPAAA X +CDK2 CDK2 P24941 human ANKRD17 26057 O75179 ANKRD17 human S2042 3176020 KEHyPVssPssPsPP X +CDK2 CDK2 P24941 human NPAT 4863 Q14207 NPAT human S1100 2286403 VsFPNLDsPNVSSTL NPAT_C X +CDK2 CDK2 P24941 human AML1 iso8 861 Q01196-8 RUNX1 human S276 454399 DTRQIQPsPPWSYDQ X +CDK2 CDK2 P24941 human CENPA 1058 P49450 CENPA human S19 478530 APRRRsPsPtPtPGP Histone X X +CDK2 CDK2 P24941 human SOX2 6657 P48431 SOX2 human S250 6738003 VVksEAsssPPVVtS X 92186 +CDK2 CDK2 P24941 human Snail2 6591 O43623 SNAI2 human S54 31961400 ILSSGAYsPITVWTT X X +CDK2 CDK2 P24941 human IREB2 3658 P48200 IREB2 human S157 2850010 LQkAGkLsPLkVQPK X +CDK2 CDK2 P24941 human RAP140 23272 Q9UK61 TASOR human T819 3952772 HEyELNStPDKKDyE X +CDK2 CDK2 P24941 human SRC-1 8648 Q15788 NCOA1 human T1426 18958502 KPTSGPQtPQAQQKS X X +CDK2 CDK2 P24941 human Rb-like 2 5934 Q08999 RBL2 human S688 449729 RLFVENDsPsDGGtP X +CDK2 CDK2 P24941 human BCLAF1 9774 Q9NYF8 BCLAF1 human T840 455929 EEWDPEytPkSKkyF X +CDK2 CDK2 P24941 human DENR 8562 O43583 DENR human S73 476007 AKLtVENsPKQEAGI X +CDK2 CDK2 P24941 human CDK16 5127 Q00536 CDK16 human S138 2192660 LEkLtLNsPIFDkPL X +CDK2 CDK2 P24941 human Trap150 9967 Q9Y2W1 THRAP3 human T874 460009 EEWDPEytPksKkyy X +CDK2 CDK2 P24941 human C1orf198 84886 Q9H425 C1orf198 human S37 4164748 FTyFSsLsPMARKIM DUF4706 X +CDK2 CDK2 P24941 human MAP2 iso2 25595 P15146-2 Map2 rat S136 448323 ETVNLPPsPPPSPAS X 4541 +CDK2 CDK2 P24941 human RFA2 6118 P15927 RPA2 human S29 448338 QsPGGFGsPAPsQAE X +CDK2 CDK2 P24941 human MCM2 4171 P49736 MCM2 human S41 452312 RtDALtssPGRDLPP X +CDK2 CDK2 P24941 human CDKN2D 1032 P55273 CDKN2D human S76 6046001 VQDTSGTsPVHDAAR Ank_2 X X +CDK2 CDK2 P24941 human SMAD2 4087 Q15796 SMAD2 human S255 448796 ELsPTTLsPVNHsLD X 3104 +CDK2 CDK2 P24941 human POLM 27434 Q9NP87 POLM human S372 28758702 HQHSCCEsPTRLAQQ DNA_pol_B_palm X +CDK2 CDK2 P24941 human MCM4 4173 P33991 MCM4 human T110 450002 PRsGVrGtPVRQRPD X +CDK2 CDK2 P24941 human PR 5241 P06401 PGR human S676 450154 LSQRFTFsPGQDIQL X +CDK2 CDK2 P24941 human EGLN2 112398 Q96KS0 EGLN2 human S130 31088285 EDGGDAPsPsKRPWA X X +CDK2 CDK2 P24941 human E2A 6929 P15923 TCF3 human S245 455906 PMLGGGSsPLPLPPG X +CDK2 CDK2 P24941 human JIP4 9043 O60271 SPAG9 human T586 3175537 NAPtSHVtPsVKKRs X +CDK2 CDK2 P24941 human Rb-like 2 5934 Q08999 RBL2 human T417 449725 KENsPCVtPVSTATH RB_A X +CDK2 CDK2 P24941 human RNF4 6047 P78317 RNF4 human T112 3801490 DVyVTtHtPRNARDE X +CDK2 CDK2 P24941 human RbBP1 5926 P29374 ARID4A human S864 14578923 RKILGQssPEkkIRI X X +CDK2 CDK2 P24941 human NOB1P 28987 Q9ULX3 NOB1 human T121 9831706 SSIQHPEtPLHISGF X +CDK2 CDK2 P24941 human SHP-1 15170 P29351 Ptpn6 mouse S591 454019 DKEKNKGsLKRK___ X X +CDK2 CDK2 P24941 human CCDC6 8030 Q16204 CCDC6 human S244 450707 QPVsAPPsPRDIsME DUF2046 X +CDK2 CDK2 P24941 human DAB1 iso2 Q6XBN7 Dab1 chicken S475 479422 TPAPRQSsPSKSSAS X +CDK2 CDK2 P24941 human LIG1 3978 P18858 LIG1 human S51 468123 GVVsEsDsPVKRPGR X X +CDK2 CDK2 P24941 human DLG1 1739 Q12959 DLG1 human S443 5931300 FLGQtPAsPARysPV PDZ_assoc X X +CDK2 CDK2 P24941 human MCL1 4170 Q07820 MCL1 human S64 479431 IGGSAGAsPPStLtP X X 13297 +CDK2 CDK2 P24941 human snRNP 70 6625 P08621 SNRNP70 human S226 451900 yDERPGPsPLPHRDR X +CDK2 CDK2 P24941 human AML1 iso8 861 Q01196-8 RUNX1 human T300 454403 sPSVHPAtPIsPGRA X +CDK2 CDK2 P24941 human Tau iso8 4137 P10636-8 MAPT human S396 449081 GAEIVyKsPVVsGDt X 9632 +CDK2 CDK2 P24941 human ATRIP 84126 Q8WXE1 ATRIP human S224 485778 APsVsHVsPRKNPSV X X 5161 +CDK2 CDK2 P24941 human CDK7 1022 P50613 CDK7 human T170 448306 GsPNRAytHQVVtRW Pkinase X +CDK2 CDK2 P24941 human PPP1R12C 54776 Q9BZL4 PPP1R12C human S509 9831735 SRIPEPEsPAKPNVP X +CDK2 CDK2 P24941 human SUV39H1 6839 O43463 SUV39H1 human S391 469894 GLAGLPGsPKKRVRI X X +CDK2 CDK2 P24941 human CRMP-1 1400 Q14194 CRMP1 human T509 454314 PVyEVPAtPKyAtPA X +CDK2 CDK2 P24941 human Tau iso8 4137 P10636-8 MAPT human S404 449082 PVVsGDtsPRHLsNV X 35834; 20194; 98523; 91600; 49562 +CDK2 CDK2 P24941 human LRCH3 84859 Q96II8 LRCH3 human S419 3209241 RRIsHEGsPVkPVAI X +CDK2 CDK2 P24941 human TFCP2 7024 Q12800 TFCP2 human S289 7965106 EITYVNNsPsPGFNS X +CDK2 CDK2 P24941 human ID3 3399 Q02535 ID3 human S5 451011 ___MkALsPVRGCyE X X +CDK2 CDK2 P24941 human Rb 5925 P06400 RB1 human T356 447981 DsFEtQRtPRksNLD X 81403; 99158 +CDK2 CDK2 P24941 human SPT5 6829 O00267 SUPT5H human T775 458815 tPMyGsQtPMyGsGs X +CDK2 CDK2 P24941 human SRC-1 8648 Q15788 NCOA1 human S1185 449064 GtPPASTsPFSQLAA DUF1518 X +CDK2 CDK2 P24941 human SCML2 10389 Q9UQR0 SCML2 human T305 3216633 SssVkNItPRKKGPN RBR X X +CDK2 CDK2 P24941 human SRC-1 8648 Q15788 NCOA1 human S1006 18958510 SPTANLPsPFQGMVR X +CDK2 CDK2 P24941 human AR 367 P10275 AR human S96 448416 QQQGEDGsPQAHRRG Androgen_recep X X +CDK2 CDK2 P24941 human PRPF3 9129 O43395 PRPF3 human T167 483115 LsFIsPPtPQPKtPS X +CDK2 CDK2 P24941 human CDK9 1025 P50750 CDK9 human S90 41625400 EICrTkAsPYNRCKG Pkinase X X +CDK2 CDK2 P24941 human Rb-like 1 5933 P28749 RBL1 human S615 36125980 HLPLMPMsPLMHPRV X +CDK2 CDK2 P24941 human ELF4 2000 Q99607 ELF4 human S648 463814 sPtPAPFsPFNPTSL X +CDK2 CDK2 P24941 human TTK 7272 P33981 TTK human T453 471487 DPkSICktPsSNtLD X +CDK2 CDK2 P24941 human C17orf49 124944 Q8IXM2 C17orf49 human S96 478219 GIPLPAEsPKKGPKK X +CDK2 CDK2 P24941 human TOPBP1 11073 Q92547 TOPBP1 human T848 3208170 DALAALEtPGRPsQQ X +CDK2 CDK2 P24941 human CTNNB1 84353 Q9WU82 Ctnnb1 rat S33 447487 QQQSYLDsGIHsGAT X 9561; 2009; 4270; 13537; 41334; 60180 +CDK2 CDK2 P24941 human hnRNP K 3190 P61978 HNRNPK human S284 448185 rrDyDDMsPrrGPPP X +CDK2 CDK2 P24941 human GRK2 156 P25098 GRK2 human S670 447725 KMKNKPRsPVVELsk X +CDK2 CDK2 P24941 human RPS27 6232 P42677 RPS27 human S27 4272667 KKkRLVQsPNsyFMD X +CDK2 CDK2 P24941 human FZR1 51343 Q9UM11 FZR1 human S163 4661904 kSQKLLRsPRKPTRK X +CDK2 CDK2 P24941 human Rb 5925 P06400 RB1 human T826 447984 LPtPtkMtPRsRILV Rb_C X +CDK2 CDK2 P24941 human NuMA-1 4926 Q14980 NUMA1 human T1776 459920 sLEsLyFtPIPARsQ X +CDK2 CDK2 P24941 human RAD54L 8438 Q92698 RAD54L human T31 3801660 DWQPGLVtPRKRKss X +CDK2 CDK2 P24941 human TFCP2 7024 Q12800 TFCP2 human S309 7965105 SLGEGNGsPNHQPEP X X +CDK2 CDK2 P24941 human UNG 7374 P13051 UNG human S23 2018600 ARKRHAPsPEPAVQG X +CDK2 CDK2 P24941 human MCM4 17217 P49717 Mcm4 mouse T19 448634 SSRRGRVtPtQsLRs X +CDK2 CDK2 P24941 human GATA3 14462 P23772 Gata3 mouse T155 33638003 HLFTFPPtPPKDVsP X +CDK2 CDK2 P24941 human hnRNP D0 3184 Q14103 HNRNPD human T193 466981 VGGLsPDtPEEkIRE RRM_1 X +CDK2 CDK2 P24941 human RRM2 6241 P31350 RRM2 human T33 3189775 sLVdkENtPPALsGt X 74736 +CDK2 CDK2 P24941 human STMN1 3925 P16949 STMN1 human S25 448555 QAFELILsPrskEsV Stathmin X +CDK2 CDK2 P24941 human RbBP1 5926 P29374 ARID4A human S1007 17743401 QHNFSVAsPLTLSQD X X +CDK2 CDK2 P24941 human Ku70 2547 P12956 XRCC6 human T455 469188 FTEkIMAtPEQVGkM Ku X +CDK2 CDK2 P24941 human SRC-1 8648 Q15788 NCOA1 human S1033 449119 tPPrGAFsPGMGMQP X +CDK2 CDK2 P24941 human Rb-like 2 5934 Q08999 RBL2 human S662 449728 GLGRsItsPttLyDR X +CDK2 CDK2 P24941 human GR 24413 P06536 Nr3c1 rat S224 447967 DLEFSAGsPSKDTNE GCR X +CDK2 CDK2 P24941 human H1F1 3024 Q02539 H1-1 human T152 13357125 ASKKSVKtPKKAKKP X +CDK2 CDK2 P24941 human CP110 9738 O43303 CCP110 human S170 22351338 RDsEGFNsPKQCDSS X X +CDK2 CDK2 P24941 human POLL 27343 Q9UGP5 POLL human T553 5312301 GPGRVLPtPTEKDVF DNA_pol_B_thumb X +CDK2 CDK2 P24941 human NUP98 4928 P52948 NUP98 human S612 470432 LNNsNLFsPVNRDsE X +CDK2 CDK2 P24941 human NPAT 4863 Q14207 NPAT human S779 2286402 ILSsPTKsPTKNAEL NPAT_C X +CDK2 CDK2 P24941 human E2A 6929 P15923 TCF3 human S139 455905 LNsPGPLsPsGMKGT X +CDK2 CDK2 P24941 human Kv-beta2 8514 Q13303 KCNAB2 human S31 3996100 IystrYGsPKRQLQF X +CDK2 CDK2 P24941 human SCML2 10389 Q9UQR0 SCML2 human S511 449227 VPyVVPLsPKLPKTk X X +CDK2 CDK2 P24941 human RPL11 6135 P62913 RPL11 human T47 4274932 LEQLtGQtPVFskAR Ribosomal_L5 X +CDK2 CDK2 P24941 human TRF2 21750 O35144 Terf2 mouse S367 452842 ANLAsPssPAHKHKR X +CDK2 CDK2 P24941 human Cortactin 2017 Q14247 CTTN human S405 447700 KtQtPPVsPAPQPtE X +CDK2 CDK2 P24941 human Rb-like 2 5934 Q08999 RBL2 human S1068 449740 HKNEtMLsPREKIFY X +CDK2 CDK2 P24941 human Akt1 207 P31749 AKT1 human S477 8086735 PQFsysAsGtA____ X X +CDK2 CDK2 P24941 human DDX48 9775 P38919 EIF4A3 human T163 3190132 GQHVVAGtPGRVFDM DEAD X X +CDK2 CDK2 P24941 human CP110 9738 O43303 CCP110 human T194 2024013 FPKTSSAtPQETLIS X X +CDK2 CDK2 P24941 human POLH 5429 Q9Y253 POLH human S687 4931282 QGkRNPksPLACTNk X X +CDK2 CDK2 P24941 human NPM1 4869 P06748 NPM1 human T234 449024 sFkkQEKtPKtPkGP X +CDK2 CDK2 P24941 human CDX2 1045 Q99626 CDX2 human S283 456208 RsVPEPLsPVSSLQA X X +CDK2 CDK2 P24941 human ETAA16 54465 Q9NY74 ETAA1 human S95 1869465805 SLSSSFSsPNDPDGQ ETAA1 X X +CDK2 CDK2 P24941 human PR 5241 P06401 PGR human S400 449842 GAEAsARsPRSYLVA Prog_receptor X +CDK2 CDK2 P24941 human FOXO1A 2308 Q12778 FOXO1 human S298 471972 QFskWPAsPGsHsND X +CDK2 CDK2 P24941 human UBE2O 63893 Q9C0C9 UBE2O human S836 484765 VEQLLTGsPtsPtVE X +CDK2 CDK2 P24941 human SMAD2 4087 Q15796 SMAD2 human S250 448795 TGsPAELsPTTLsPV X 3104 +CDK2 CDK2 P24941 human MDM2 17246 P23804 Mdm2 mouse T216 450150 SSSESTEtPSHQDLD X +CDK2 CDK2 P24941 human EEF2 1938 P13639 EEF2 human S595 27620701 NVLCLsksPNkHNRL X X +CDK2 CDK2 P24941 human RbBP1 5926 P29374 ARID4A human S1140 14578926 KPQKLARsPARIsPH X +CDK2 CDK2 P24941 human SFRS9 8683 Q13242 SRSF9 human S216 465904 rGsPHyFsPFRPy__ X +CDK2 CDK2 P24941 human Caldesmon 800 Q05682 CALD1 human T730 448467 ssPtAAGtPNkEtAG Caldesmon X +CDK2 CDK2 P24941 human LIG3 3980 P49916 LIG3 human T191 2883701 LSSKAAGtPKKKAVV X +CDK2 CDK2 P24941 human CDK7 1022 P50613 CDK7 human S164 450041 GLAksFGsPNRAytH Pkinase X +CDK2 CDK2 P24941 human RbBP1 5926 P29374 ARID4A human T1124 17772902 LDNSSKCtPVKHLNV X +CDK2 CDK2 P24941 human SOX2 20674 P48432 Sox2 mouse S39 18913847 TGGNQkNsPDRVKRP X +CDK2 CDK2 P24941 human PLZF 7704 Q05516 ZBTB16 human T282 2134716 RGKEGPGtPTRSSVI X X +CDK2 CDK2 P24941 human SRC-1 8648 Q15788 NCOA1 human T1271 18958508 QSSLLQQtPPASGYQ X +CDK2 CDK2 P24941 human SRC-1 8648 Q15788 NCOA1 human S395 449116 PsVNPsIsPAHGVAR X +CDK2 CDK2 P24941 human ORC2 4999 Q13416 ORC2 human T226 7320974 sAPVGKEtPsKRMKR X X +CDK2 CDK2 P24941 human Rb 5925 P06400 RB1 human T252 449821 PINGsPRtPRRGQNR X X +CDK2 CDK2 P24941 human STMN1 3925 P16949 STMN1 human S38 448556 sVPEFPLsPPkKkDL Stathmin X 3426; 4191 +CDK2 CDK2 P24941 human SPT6 6830 Q7KZ85 SUPT6H human T1523 3203790 QDPVPGItPSsssRt X +CDK2 CDK2 P24941 human MAP2 25595 P15146 Map2 rat S136 448323 ETVNLPPsPPPsPAS X 4541 +CDK2 CDK2 P24941 human FOXC1 2296 Q12948 FOXC1 human T68 3950892 ArAYGPYtPQPQPKD X +CDK2 CDK2 P24941 human MTHFD1L 25902 Q6UB35 MTHFD1L human S357 9831636 CLkLQPLsPVPSDIE X +CDK2 CDK2 P24941 human Rb-like 2 5934 Q08999 RBL2 human T642 449727 CIAGsPLtPRRVtEV X +CDK2 CDK2 P24941 human MCL1 4170 Q07820 MCL1 human S121 1172400 PAADAIMsPEEELDG X +CDK2 CDK2 P24941 human SETDB1 9869 Q15047 SETDB1 human S1066 3196787 RNYGYNPsPVkPEGL SET X +CDK2 CDK2 P24941 human B-Myb 4605 P10244 MYBL2 human T518 450111 SMDNtPHtPtPFkNA Cmyb_C X +CDK2 CDK2 P24941 human LARP 23367 Q6PKG0 LARP1 human T649 468112 KILIVtQtPHyMRRH X +CDK2 CDK2 P24941 human B-Myb 4605 P10244 MYBL2 human S577 450115 RKPGLRRsPIKKVRk Cmyb_C X +CDK2 CDK2 P24941 human PR 5241 P06401 PGR human S190 447986 kVLPRGLsPARQLLL Prog_receptor X 3171 +CDK2 CDK2 P24941 human TFCP2 7024 Q12800 TFCP2 human S291 7965107 TYVNNsPsPGFNSSH X +CDK2 CDK2 P24941 human ACF7 23499 Q9UPN3 MACF1 human T7213 9831680 EGAsQGMtPFRsRGR X +CDK2 CDK2 P24941 human Lamin B2 84823 Q03252 LMNB2 human S37 455588 GGPAtPLsPtRLsRL X +CDK2 CDK2 P24941 human LIG3 3980 P49916 LIG3 human S913 2883700 EkLAtKssPVKVGEK X +CDK2 CDK2 P24941 human BARD1 580 Q99728 BARD1 human S148 455770 NSIkMWFsPRSkKVR X +CDK2 CDK2 P24941 human LARP 23367 Q6PKG0 LARP1 human S774 453830 LPttVPEsPNyRNtR X +CDK2 CDK2 P24941 human MCM2 4171 P49736 MCM2 human S40 452311 RRtDALtssPGRDLP X +CDK2 CDK2 P24941 human EVI1 2122 Q03112 MECOM human S624 4702996 KMFKDkVsPLQNLAS X +CDK2 CDK2 P24941 human ETAA16 54465 Q9NY74 ETAA1 human S111 1869465806 DIFWDQNsPLTKQLG ETAA1 X X +CDK2 CDK2 P24941 human PXR 8856 O75469 NR1I2 human T135 30259804 KKSERtGtQPLGVQG X +CDK2 CDK2 P24941 human FZR1 51343 Q9UM11 FZR1 human T121 3827860 DRRLQPstPEKkGLF X +CDK2 CDK2 P24941 human PAICS 10606 P22234 PAICS human S27 483584 EVyELLDsPGkVLLQ SAICAR_synt X +CDK2 CDK2 P24941 human NBS1 27354 Q9R207 Nbn mouse S433 483547 KtPsYQLsPMKFPVA X +CDK2 CDK2 P24941 human RANGAP1 19387 P46061 Rangap1 mouse T411 2906105 GSGEEPAtPSRKILD RanGAP1_C X +CDK2 CDK2 P24941 human SF3B1 23451 O75533 SF3B1 human T313 449360 HGsGWAEtPRtDrGG X 25009 +CDK2 CDK2 P24941 human NUDE1 iso1 54820 Q9NXR1-1 NDE1 human T228 449452 GPsssLNtPGsFRRG NUDE_C X +CDK2 CDK2 P24941 human PMS2 18861 P54279 Pms2 mouse T337 1881225900 ECVDINVtPDKRQIL X +CDK2 CDK2 P24941 human CDC6 990 Q99741 CDC6 human S74 450915 tPHLPPCsPPKQGKK X X +CDK2 CDK2 P24941 human SMAD2 4087 Q15796 SMAD2 human S245 448794 NQsMDTGsPAELsPT X 3104 +CDK2 CDK2 P24941 human UNG 7374 P13051 UNG human S64 2018601 EPGtPPssPLsAEQL X +CDK2 CDK2 P24941 human NUP133 55746 Q8WUM0 NUP133 human S50 483775 VssPVLFsPVGrRss X +CDK2 CDK2 P24941 human Rb 5925 P06400 RB1 human S567 450021 SLAWLSDsPLFDLIk RB_A X +CDK2 CDK2 P24941 human RAD18 56852 Q9NS91 RAD18 human S99 449217 LLQFALEsPAksPAs X +CDK2 CDK2 P24941 human MCM7 4176 P33993 MCM7 human S365 10027300 LVGGVDQsPRGMKIR MCM X +CDK2 CDK2 P24941 human DNMT1 1786 P26358 DNMT1 human S154 476108 AkPEPsPsPRITRkS X +CDK2 CDK2 P24941 human LIG1 3978 P18858 LIG1 human S76 449246 EEEDEALsPAkGQKP X X +CDK2 CDK2 P24941 human BRCA1 672 P38398 BRCA1 human S114 18007298 FAkKENNsPEHLkDE X +CDK2 CDK2 P24941 human Rb 5925 P06400 RB1 human S249 447975 AVIPINGsPRtPRRG X X +CDK2 CDK2 P24941 human FOXK2 3607 Q01167 FOXK2 human S428 3193961 FAQsAPGsPLssQPV X +CDK2 CDK2 P24941 human NRIF3 23421 Q13352 ITGB3BP human S33 455815 KKsVITysPTTGTCQ CENP-R X +CDK2 CDK2 P24941 human Kv-beta2 29738 P62483 Kcnab2 rat S31 3996100 IyStRYGsPKRQLQF X X +CDK2 CDK2 P24941 human Chk1 1111 O14757 CHEK1 human S301 465528 IQsNLDFsPVNsAss X +CDK2 CDK2 P24941 human CCNO 10309 P22674 CCNO human S81 7445148 PSAARGGsPLPGPAQ X +CDK2 CDK2 P24941 human CTTNBP2NL 55917 Q9P2B4 CTTNBP2NL human S563 453212 ssPLsPLsPGIKsPt X +CDK2 CDK2 P24941 human HMGA1 3159 P17096 HMGA1 human S36 455950 PRkQPPVsPGtALVG X +CDK2 CDK2 P24941 human RRM2 6241 P31350 RRM2 human S20 457399 DPQQLQLsPLkGLsL X +CDK2 CDK2 P24941 human NPM1 4869 P06748 NPM1 human T199 448515 VkKsIrDtPAkNAQK X 3541; 75984 +CDK2 CDK2 P24941 human UNG 7374 P13051 UNG human T60 452622 AGQEEPGtPPssPLs X +CDK2 CDK2 P24941 human LIG3 3980 P49916 LIG3 human S210 468127 TttGQVtsPVkGAsF X X +CDK2 CDK2 P24941 human BRCA1 672 P38398 BRCA1 human S1497 448730 EPGVERssPsKCPsL X X +CDK2 CDK2 P24941 human Rb-like 2 5934 Q08999 RBL2 human T694 449730 DsPsDGGtPGRMPPQ X +CDK2 CDK2 P24941 human Rb 5925 P06400 RB1 human S612 447977 MyLsPVRsPKKKGsT X +CDK2 CDK2 P24941 human NUCKS 64710 Q9H1E3 NUCKS1 human S181 452956 LkAtVtPsPVkGkGk X +CDK2 CDK2 P24941 human p63 8626 Q9H3D4 TP63 human T491 4668106 PQQRNALtPTTIPDG X X +CDK2 CDK2 P24941 human C/EBP-beta 24253 P21272 Cebpb rat S64 456166 HERAIDFsPYLEPLA X +CDK2 CDK2 P24941 human Rb-like 2 5934 Q08999 RBL2 human S413 449724 VRYIKENsPCVtPVS X +CDK2 CDK2 P24941 human MDC1 9656 Q14676 MDC1 human S1068 486515 LAPPPLLsPLLPSIk X +CDK2 CDK2 P24941 human PHF8 23133 Q9UPP1 PHF8 human S880 3216126 NsDDAPWsPKARVtP X X +CDK2 CDK2 P24941 human SKP2 6502 Q13309 SKP2 human S64 457412 sNLGHPEsPPRkRLk X X 14865 +CDK2 CDK2 P24941 human MASTL 84930 Q96GX5 MASTL human T194 3209097 NMMDILTtPSMAkPR Pkinase X +CDK2 CDK2 P24941 human SRC-1 8648 Q15788 NCOA1 human T979 18958506 RFPPQQAtPPLIMEE X +CDK2 CDK2 P24941 human AML1 iso8 861 Q01196-8 RUNX1 human S303 454401 VHPAtPIsPGRASGM X +CDK2 CDK2 P24941 human CP110 9738 O43303 CCP110 human S372 9318022 PsPEPsMsPKMHRRR X X +CDK2 CDK2 P24941 human SOX2 6657 P48431 SOX2 human S249 6738004 SVVksEAsssPPVVt X +CDK2 CDK2 P24941 human MCM4 17217 P49717 Mcm4 mouse S53 448667 ELLPMPTsPGADLQS X +CDK2 CDK2 P24941 human p27Kip1 1027 P46527 CDKN1B human T187 447875 NAGsVEQtPKKPGLR X X +CDK2 CDK2 P24941 human Rb-like 1 5933 P28749 RBL1 human S640 451296 RRDMQPLsPIsVHER X +CDK2 CDK2 P24941 human TNRC15 26058 Q6Y7W6 GIGYF2 human S593 3203298 MWGRVPFsPGPAPPP X +CDK2 CDK2 P24941 human SIRT2 iso2 22933 Q8IXJ6-2 SIRT2 human S331 482809 PNPSTSAsPKKSPPP X +CDK2 CDK2 P24941 human SRC-1 8648 Q15788 NCOA1 human S569 449118 RQMssQNsPSRLNIQ NCOA_u2 X +CDK2 CDK2 P24941 human PXR 8856 O75469 NR1I2 human S114 30259801 MKkEMIMsDEAVEER X +CDK2 CDK2 P24941 human RAD9A 5883 Q99638 RAD9A human S328 449812 VLPsIsLsPGPQPPK X X +CDK2 CDK2 P24941 human PELP1 27043 Q8IZL8 PELP1 human S477 470174 ADALKLRsPRGsPDG NUC202 X +CDK2 CDK2 P24941 human MCL1 4170 Q07820 MCL1 human T92 4825134 EVPDVTAtPARLLFF X +CDK2 CDK2 P24941 human BARD1 580 Q99728 BARD1 human S251 455769 sQPSVISsPQINGEI X +CDK2 CDK2 P24941 human CDT1 81620 Q9H211 CDT1 human T29 455584 PPkLACRtPsPARPA X +CDK2 CDK2 P24941 human Tau iso8 4137 P10636-8 MAPT human S202 447928 sGyssPGsPGtPGsR X 39357; 30505 +CDK2 CDK2 P24941 human AARSL 57505 Q5JTZ9 AARS2 human T673 9831755 VTTQTPLtPEQLRAV X +CDK2 CDK2 P24941 human Rb-like 2 5934 Q08999 RBL2 human T1097 449742 sMIRTGEtPTKKRGI X +CDK2 CDK2 P24941 human MLH1 17350 Q9JK91 Mlh1 mouse T495 1881245400 NASGKEMtAACYPRR X +CDK2 CDK2 P24941 human DENR 8562 O43583 DENR human T69 476008 PNEFAKLtVENsPKQ X +CDK2 CDK2 P24941 human RRM1 6240 P23921 RRM1 human S559 31890671 PyEtyEGsPVSkGIL Ribonuc_red_lgC X X +CDK2 CDK2 P24941 human ZNF261 9203 Q14202 ZMYM3 human T826 3801541 PPPPPPAtPRKNKAA X +CDK2 CDK2 P24941 human ATF-2 1386 P15336 ATF2 human T116 3180684 LDLsPLAtPIIRsKI X +CDK2 CDK2 P24941 human RALY 22913 Q9UKM9 RALY human S135 465875 FDYrGRLsPVPVPrA X +CDK2 CDK2 P24941 human RNF4 6047 P78317 RNF4 human T26 41192600 RTREATStPEISLEA X +CDK2 CDK2 P24941 human NRF1 4899 Q16656 NRF1 human S136 23255800 QAIVLCIsPskPNPV Nrf1_DNA-bind X +CDK2 CDK2 P24941 human NRIF3 23421 Q13352 ITGB3BP human S46 455816 CQMSLFAsPTSSEEQ CENP-R X +CDK2 CDK2 P24941 human p21Cip1 1026 P38936 CDKN1A human S130 455618 sGEQAEGsPGGPGDs X X +CDK2 CDK2 P24941 human CTNNB1 84353 Q9WU82 Ctnnb1 rat S37 447582 YLDsGIHsGATtTAP X 9561; 2009; 4270; 13537; 41334; 60180 +CDK2 CDK2 P24941 human ING5 84289 Q8WYH8 ING5 human T152 23115779 RRtsEEDtPkkKKHK X X +CDK2 CDK2 P24941 human BIN1 274 O00499 BIN1 human T348 7532308 VPPPPKHtPSKEVKQ X +CDK2 CDK2 P24941 human PTP-PEST 5782 Q05209 PTPN12 human S19 18014400 QRVQAMKsPDHNGED X X +CDK2 CDK2 P24941 human TRF2 7014 Q15554 TERF2 human S365 452842 PTQALPAsPALKNKR X X +CDK2 CDK2 P24941 human RECQL4 9401 O94761 RECQL4 human S251 25173044 EVSIRVGsPQPSSSG X X +CDK2 CDK2 P24941 human Diaphanous-3 81624 Q9NSV4 DIAPH3 human T19 9831662 AQGSAAGtPYPsSAs X +CDK2 CDK2 P24941 human ER-alpha 2099 P03372 ESR1 human S118 448101 LHPPPQLsPFLQPHG Oest_recep X 2511 +CDK2 CDK2 P24941 human IMPDH2 3615 P12268 IMPDH2 human S122 3180540 ITDPVVLsPkDRVRD IMPDH; CBS X +CDK2 CDK2 P24941 human SF3B1 23451 O75533 SF3B1 human T211 468708 ADQtPGAtPkkLssW X +CDK2 CDK2 P24941 human Afadin 4301 P55196 AFDN human T1352 9831600 TPAAIPAtPVAVSQP X +CDK2 CDK2 P24941 human NCAPH 23397 Q15003 NCAPH human T49 459684 APLNIPGtPVLEDFP Cnd2 X +CDK2 CDK2 P24941 human SMAD3 4088 P84022 SMAD3 human S208 451179 DAGsPNLsPNPMsPA X +CDK2 CDK2 P24941 human C/EBP-beta 24253 P21272 Cebpb rat T189 447878 SSSsPPGtPSPADAK X 3084 +CDK2 CDK2 P24941 human TORC2 200186 Q53ET0 CRTC2 human S433 454653 HHRRVPLsPLsLLAG X +CDK2 CDK2 P24941 human hnRNP H1 3187 P31943 HNRNPH1 human S104 455395 LkHtGPNsPDtANDG X +CDK2 CDK2 P24941 human ER-alpha 2099 P03372 ESR1 human S106 448100 PLNsVsPsPLMLLHP Oest_recep X +CDK2 CDK2 P24941 human CtIP 5932 Q99708 RBBP8 human T315 4766297 FsDSTSktPPQEELP X +CDK2 CDK2 P24941 human TERF2IP 54386 Q9NYB0 TERF2IP human S203 454348 LLGDAPVsPssQkLK X +CDK2 CDK2 P24941 human PXR 8856 O75469 NR1I2 human S200 30259805 REEAAKWsQVRKDLC X +CDK2 CDK2 P24941 human MCM3 17215 P25206 Mcm3 mouse S611 2840506 SSDTARTsPVTARTL MCM_lid X +CDK2 CDK2 P24941 human HIRA 7290 P54198 HIRA human T555 448427 LsPsVLttPsKIEPM X X +CDK2 CDK2 P24941 human SRC-1 8648 Q15788 NCOA1 human T789 18958504 DPCNTNPtPMTKPTP X +CDK2 CDK2 P24941 human RAMP 51514 Q9NZJ0 DTL human T464 4717290 DLPLPsNtPTFSIKt X +CDK2 CDK2 P24941 human CDC25C 995 P30307 CDC25C human S214 448417 sRsGLyRsPsMPENL M-inducer_phosp X +CDK2 CDK2 P24941 human CP110 9738 O43303 CCP110 human S516 23095734 ASSQCIAsPNFGTVS X X +CDK2 CDK2 P24941 human SF3B1 23451 O75533 SF3B1 human T248 455542 GsEtPGAtPGsKIWD X +CDK2 CDK2 P24941 human TR-beta1 iso2 21834 P37242-2 Thrb mouse S101 1877436600 KPFPQVQsPPHSQKK X X +CDK2 CDK2 P24941 human BARD1 580 Q99728 BARD1 human T299 455768 KSRNEVVtPEKVCkN X +CDK2 CDK2 P24941 human ER-alpha 2099 P03372 ESR1 human S294 451560 RAANLWPsPLMIkRS X X +CDK2 CDK2 P24941 human RPL12 6136 P30050 RPL12 human S38 468652 kIGPLGLsPkkVGDD Ribosomal_L11_N X X +CDK2 CDK2 P24941 human FZR1 51343 Q9UM11 FZR1 human S40 3215931 PAssPVssPsKHGDR X +CDK2 CDK2 P24941 human UBE2A 7319 P49459 UBE2A human S120 448007 LDEPNPNsPANSQAA UQ_con X X +CDK2 CDK2 P24941 human FOXM1 iso2 2305 Q08050-2 FOXM1 human T596 451437 ETLPISStPSKSVLP X +CDK2 CDK2 P24941 human Rb-like 2 5934 Q08999 RBL2 human S1080 449741 IFYYFsNsPsKRLRE X +CDK2 CDK2 P24941 human vinexin iso10 10174 O60504_VAR_055019 SORBS3 human S563 452555 tDLGGQtsPRRTGFS X +CDK2 CDK2 P24941 human SF3B1 23451 O75533 SF3B1 human T244 455541 GRAkGsEtPGAtPGs X +CDK2 CDK2 P24941 human SRC-1 8648 Q15788 NCOA1 human S1250 18958511 ANFAPSLsPGSSMVP DUF1518 X +CDK2 CDK2 P24941 human WRN 7486 Q14191 WRN human S1133 10940893 KksIMVQsPEKAYSS X X +CDK2 CDK2 P24941 human PELP1 27043 Q8IZL8 PELP1 human S991 15334104 PALPPPEsPPKVQPE X X +CDK2 CDK2 P24941 human OLIG2 50913 Q9EQW6 Olig2 mouse S14 18357901 LVSsRPssPEPDDLF X +CDK2 CDK2 P24941 human TICRR 90381 Q7Z2Z1 TICRR human S1001 4752817 DIGVVEEsPEKGDEI Treslin_N X X +CDK2 CDK2 P24941 human DDX3 1654 O00571 DDX3X human T204 457783 LTRyTRPtPVQkHAI DEAD X +CDK2 CDK2 P24941 human QTRT1 81890 Q9BXR0 QTRT1 human S139 9831771 DGNETLLsPEKSVQI TGT X +CDK2 CDK2 P24941 human LIG1 3978 P18858 LIG1 human S91 2999200 ALDCSQVsPPRPAts X X +CDK2 CDK2 P24941 human TSPYL2 64061 Q9H2G4 TSPYL2 human T340 12559513 GRLVSHstPIRWHRG NAP X +CDK2 CDK2 P24941 human CtIP 5932 Q99708 RBBP8 human T847 7113805 FRYIPPNtPENFWEV SAE2 X X +CDK2 CDK2 P24941 human MED1 5469 Q15648 MED1 human T1215 3197162 PMkPVPGtPPsSKAK X +CDK2 CDK2 P24941 human CP110 9738 O43303 CCP110 human S366 9314148 GSYAkLPsPEPsMsP X X +CDK2 CDK2 P24941 human PLZF 7704 Q05516 ZBTB16 human S197 2134715 SFGLSAMsPTKAAVD X X +CDK2 CDK2 P24941 human SF3B1 23451 O75533 SF3B1 human T142 455974 PFADGGktPDPkMNA X +CDK2 CDK2 P24941 human CROCC iso2 9696 Q5TZA2-2 CROCC human S763 14159744 APRPVPGsPARDAPA X X +CDK2 CDK2 P24941 human Snail2 6591 O43623 SNAI2 human S104 25603909 KDHsGSEsPISDEEE X X +CDK2 CDK2 P24941 human EZH2 14056 Q61188 Ezh2 mouse T416 10417699 EANsRCQtPIKMKPN X +CDK2 CDK2 P24941 human eIF4G 1981 Q04637 EIF4G1 human T647 3194303 VLDKANktPLRPLDP X +CDK2 CDK2 P24941 human TUBG2 27175 Q9NRH3 TUBG2 human S80 23070049 VIHSILNsPYAkLYN Tubulin X +CDK2 CDK2 P24941 human CP110 9738 O43303 CCP110 human S400 4744475 PINACELsPKGKEQA X X +CDK2 CDK2 P24941 human USP37 57695 Q86T82 USP37 human S628 469345 MVNsCItsPStPSKK UCH X X +CDK2 CDK2 P24941 human SMAD3 4088 P84022 SMAD3 human S204 451178 NHSMDAGsPNLsPNP X +CDK2 CDK2 P24941 human MCM2 4171 P49736 MCM2 human S13 473057 EsFtMAssPAQRRRG X +CDK2 CDK2 P24941 human DLG1 1739 Q12959 DLG1 human S158 2024309 FVsHsHIsPIKPTEA MAGUK_N_PEST X X +CDK2 CDK2 P24941 human NCL 4691 P19338 NCL human T76 483581 tkkVAVAtPAkkAAV X +CDK2 CDK2 P24941 human ANKLE2 23141 Q86XL3 ANKLE2 human S528 478556 RAFAGPLsPAkAEDF X +CDK2 CDK2 P24941 human WHSC2 7469 Q9H3P2 NELFA human T157 452967 TTLAGPLtPPVkHFQ X +CDK2 CDK2 P24941 human LIG1 3978 P18858 LIG1 human T233 468125 kTLssFFtPRKPAVk X +CDK2 CDK2 P24941 human FOXP3 20371 Q99JB6 Foxp3 mouse T175 29672100 CTFPRSGtPRKDSNL X +CDK2 CDK2 P24941 human ZHX1 11244 Q9UKY1 ZHX1 human T568 9831792 WNPFPDFtPQKFKEK X +CDK2 CDK2 P24941 human CIZ1 68379 Q8VEH2 Ciz1 mouse T293 15418576 TAPKQTQtPDRLPEP X +CDK2 CDK2 P24941 human RbBP1 5926 P29374 ARID4A human S1145 14578929 ARsPARIsPHIKDGE X +CDK2 CDK2 P24941 human RFA2 6118 P15927 RPA2 human S33 448339 GFGsPAPsQAEkkSR X 10148 +CDK2 CDK2 P24941 human MCM4 17217 P49717 Mcm4 mouse S3 448666 _____MssPAstPsR X X +CDK2 CDK2 P24941 human MDC1 9656 Q14676 MDC1 human T1630 471610 tstDQPVtPKLTSRA X +CDK2 CDK2 P24941 human POLL 27343 Q9UGP5 POLL human S230 5312300 LEGDCEPsPAPAVLD X +CDK2 CDK2 P24941 human NPM1 4869 P06748 NPM1 human S70 459898 EAMNyEGsPIkVtLA Nucleoplasmin X +CDK2 CDK2 P24941 human ORC2 4999 Q13416 ORC2 human T116 3195386 LAsELAKtPQKSVsF X X +CDK2 CDK2 P24941 human MCM4 4173 P33991 MCM4 human S32 450001 RsEDARssPsQRRRG X +CDK2 CDK2 P24941 human NPAT 4863 Q14207 NPAT human T1270 2286400 sDLPVPRtPGSGAGE NPAT_C X X +CDK2 CDK2 P24941 human MRPS18B 28973 Q9Y676 MRPS18B human S49 4269907 sLSSVPIsPYkDEPW X +CDK2 CDK2 P24941 human RFA2 6118 P15927 RPA2 human S23 448337 GAGGYtQsPGGFGsP X +CDK2 CDK2 P24941 human MDC1 9656 Q14676 MDC1 human T341 3196397 EEERIPAtPVVIPMK X +CDK2 CDK2 P24941 human CP110 9738 O43303 CCP110 human T566 35546004 NTRQQMDtPMVSCGN X X +CDK2 CDK2 P24941 human BRCA2 675 P51587 BRCA2 human T77 15418117 syNQLAstPIIFKEQ X +CDK2 CDK2 P24941 human ORC1L 4998 Q13415 ORC1 human S273 7320969 VAFsEITsPsKRSQP X +CDK2 CDK2 P24941 human BLM 641 P54132 BLM human S175 23086547 sFVtPPQsHFVRVSt BLM_N X +CDK2 CDK2 P24941 human DRP1 10059 O00429 DNM1L human S616 454690 PIPIMPAsPQKGHAV X 3455; 4494; 63940 +CDK2 CDK2 P24941 human Rb-like 1 5933 P28749 RBL1 human S650 455534 sVHERySsPtAGSAk X +CDK2 CDK2 P24941 human UNG 7374 P13051 UNG human S12 3180591 ktLysFFsPsPARKR X +CDK2 CDK2 P24941 human RECQL4 9401 O94761 RECQL4 human S89 25173042 LNRAATKsPQStPGR Drc1-Sld2 X X +CDK2 CDK2 P24941 human requiem 5977 Q92785 DPF2 human T176 3208425 DEDyEEDtPkRRGKG X +CDK2 CDK2 P24941 human ADD3 120 Q9UEY8 ADD3 human S423 2050001 EDDtVPLsPLkyMAQ X +CDK2 CDK2 P24941 human INCA1 388324 Q0VD86 INCA1 human S191 12524603 GRAQLLWsPWSPLDQ X +CDK2 CDK2 P24941 human CDC7 8317 O00311 CDC7 human T376 2864203 QVAPRAGtPGFRAPE Pkinase X +CDK2 CDK2 P24941 human CDK2 1017 P24941 CDK2 human T160 447739 GVPVRtytHEVVtLW Pkinase X 2561 +CDK2 CDK2 P24941 human HuR 1994 Q15717 ELAVL1 human S202 3197192 LLsQLyHsPArrFGG X +CDK2 CDK2 P24941 human CCNE1 898 P24864 CCNE1 human T395 447676 PLPSGLLtPPQsGKK X X +CDK2 CDK2 P24941 human Rb 5925 P06400 RB1 human T821 447983 kIsEGLPtPtkMtPR Rb_C X X 31433 +CDK2 CDK2 P24941 human CDC6 990 Q99741 CDC6 human S54 450914 RVkALPLsPRKRLGD X X +CDK2 CDK2 P24941 human MCL1 4170 Q07820 MCL1 human T163 455375 tDGsLPstPPPAEEE X 4579; 14765 +CDK2 CDK2 P24941 human Rb 5925 P06400 RB1 human T373 447982 VNVIPPHtPVRTVMN RB_A X +CDK2 CDK2 P24941 human SRC-1 8648 Q15788 NCOA1 human S997 18958509 LYSQPYSsPSPTANL X +CDK2 CDK2 P24941 human Myc 4609 P01106 MYC human S77 448586 LLPtPPLsPsRRsGL Myc_N X 13748 +CDK2 CDK2 P24941 human TSPYL2 64061 Q9H2G4 TSPYL2 human S20 3212187 RRLsssEsPQRDPPP X +CDK2 CDK2 P24941 human TNKS1BP1 85456 Q9C0C2 TNKS1BP1 human S691 452486 WLDDLLAsPPPsGGG X +CDK2 CDK2 P24941 human Rb-like 2 5934 Q08999 RBL2 human S952 449732 DSRsHQNsPtELNKD RB_B X +CDK2 CDK2 P24941 human B-Myb 4605 P10244 MYBL2 human T520 450112 DNtPHtPtPFkNALE Cmyb_C X +CDK2 CDK2 P24941 human BARD1 580 Q99728 BARD1 human S288 467302 PLAEQIEsPDTKSRN X +CDK2 CDK2 P24941 human NSBP1 79366 P82970 HMGN5 human T31 456124 sAMLVPVtPEVkPKR HMG14_17 X +CDK2 CDK2 P24941 human FOXK2 68837 Q3UCQ1 Foxk2 mouse S190 36124957 HLISPLPsPTGTISA X +CDK2 CDK2 P24941 human SPT5 6829 O00267 SUPT5H human T791 458817 tPMyGsQtPLQDGsR X +CDK2 CDK2 P24941 human MAP2 iso3 25595 P15146-3 Map2 rat S136 448323 ETVNLPPsPPPSPAS X 4541 +CDK2 CDK2 P24941 human GRASP55 26003 Q9H8Y8 GORASP2 human T225 470123 QMAGtPItPLKDGFT X +CDK2 CDK2 P24941 human PR 5241 P06401 PGR human S213 450155 SGAPVKPsPQAAAVE Prog_receptor X +CDK2 CDK2 P24941 human APC 324 P25054 APC human S1360 3188801 EFsSGAKsPsKsGAQ APC_u9 X +CDK2 CDK2 P24941 human Rb-like 2 5934 Q08999 RBL2 human S1044 449739 yPFVRtGsPRRIQLS X +CDK2 CDK2 P24941 human KLF10 7071 Q13118 KLF10 human S206 7320931 NIPCAAVsPNRSKCE X X +CDK2 CDK2 P24941 human TUBG1 7283 P23258 TUBG1 human S80 9831761 VIHSILNsPYAkLYN Tubulin X +CDK2 CDK2 P24941 human B-Myb 17865 P48972 Mybl2 mouse T497 450109 tPLHRDKtPLHQKYP Cmyb_C X +CDK2 CDK2 P24941 human PR 5241 P06401 PGR human S162 450156 PATQRVLsPLMSRSG Prog_receptor X +CDK2 CDK2 P24941 human TPX2 22974 Q9ULW0 TPX2 human T72 460008 NLQQAIVtPLkPVDN X X +CDK2 CDK2 P24941 human NPAT 4863 Q14207 NPAT human S775 2286404 LPTIILSsPTKsPTK NPAT_C X +CDK2 CDK2 P24941 human ELK4 2005 P28324 ELK4 human T194 41290001 SVIKFVTtPSKKPPV X X +CDK2 CDK2 P24941 human TFCP2 7024 Q12800 TFCP2 human T258 8046512 REKMEKRtPHEKEKY CP2 X +CDK2 CDK2 P24941 human MLL4 8085 O14686 KMT2D human T5374 9831697 TFTGETNtPYSkQFV X +CDK2 CDK2 P24941 human PML 5371 P29590 PML human S518 465867 PsTSkAVsPPHLDGP DUF3583 X X +CDK2 CDK2 P24941 human BAT2 7916 P48634 PRRC2A human T1353 9831624 LtPKAVGtPGGGGGG X +CDK2 CDK2 P24941 human CCNA2 890 P20248 CCNA2 human S154 3140800 PMDGSFEsPHTMDMS Cyclin_N2 X X +CDK2 CDK2 P24941 human INCA1 388324 Q0VD86 INCA1 human T182 12524604 QEEDRFLtPGRAQLL INCA1 X +CDK2 CDK2 P24941 human RPS27L 51065 Q71UM5 RPS27L human S27 7446456 KKkRLVQsPNsyFMD X +CDK2 CDK2 P24941 human MYST2 11143 O95251 KAT7 human T88 468239 QQQPtPVtPkKYPLR X +CDK2 CDK2 P24941 human NFAT90 3609 Q12906 ILF3 human S382 456735 EEDGEEKsPsKKKKK X X +CDK2 CDK2 P24941 human ANKRD17 26057 O75179 ANKRD17 human S2045 484761 yPVssPssPsPPAQP X +CDK2 CDK2 P24941 human ZNF609 23060 O15014 ZNF609 human T722 9831796 FTVNPALtPAKDKKK X +CDK2 CDK2 P24941 human MCM2 4171 P49736 MCM2 human S108 456310 DVEELtAsQREAAER MCM2_N X +CDK2 CDK2 P24941 human SF3B1 23451 O75533 SF3B1 human T354 452215 GGstPVLtPGKTPIG SF3b1 X +CDK2 CDK2 P24941 human PTPN2 iso2 5771 P17706-2 PTPN2 human S304 451134 LSPAFDHsPNKIMTE X X +CDK2 CDK2 P24941 human ORC1L 4998 Q13415 ORC1 human T375 11329800 AQNEAtstPHRIRRK X +CDK2 CDK2 P24941 human TOB2 10766 Q14106 TOB2 human S254 14161520 PAPQSQLsPNAKEFV PAM2 X X +CDK2 CDK2 P24941 human MCL1 4170 Q07820 MCL1 human T70 31857746 AsPPStLtPDSRRVA X X +CDK2 CDK2 P24941 human SAMHD1 25939 Q9Y3Z3 SAMHD1 human T592 468674 DVIAPLItPQkkEWN X 89930; 87593; 55092; 45205 +CDK2 CDK2 P24941 human ARID1A 8289 O14497 ARID1A human S363 3857177 RSHHAPMsPGssGGG X +CDK2 CDK2 P24941 human SPT5 6829 O00267 SUPT5H human S666 468817 VGGFAPMsPrISsPM X +CDK2 CDK2 P24941 human TICRR 90381 Q7Z2Z1 TICRR human T969 20798601 LTKSVAEtPVHKQIS Treslin_N X X +CDK2 CDK2 P24941 human EZH2 2146 Q15910 EZH2 human T416 10417699 EANsRCQtPIKMkPN X X +CDK2 CDK2 P24941 human UHRF1 iso2 29128 Q96T88-2 UHRF1 human S674 469962 GGPSRAGsPRRTSKK X +CDK2 CDK2 P24941 human SF3B1 23451 O75533 SF3B1 human T426 7989958 AGyVPIRtPARkLtA SF3b1 X +CDK2 CDK2 P24941 human FOXK2 68837 Q3UCQ1 Foxk2 mouse S200 1876808206 GTISAANsCPSSPRG X +CDK2 CDK2 P24941 human HN1L 90861 Q9H910 JPT2 human S97 483850 ktSDIFGsPVtAtsr X +CDK2 CDK2 P24941 human FOXO1A 56458 Q9R1E0 Foxo1 mouse S246 471071 EGGkSGksPRRRAAs X X +CDK2 CDK2 P24941 human PXR 8856 O75469 NR1I2 human S350 4668103 MQAISLFsPDRPGVL Hormone_recep X X +CDK2 CDK2 P24941 human FOXP3 20371 Q99JB6 Foxp3 mouse S19 12201088 PSLALGPsPGVLPSW X +CDK2 CDK2 P24941 human UHRF1 29128 Q96T88 UHRF1 human S661 469962 GGPSrAGsPRRTSKK X +CDK2 CDK2 P24941 human NBS1 4683 O60934 NBN human S432 483547 RIPNyQLsPtKLPsI X X +CDK2 CDK2 P24941 human Nogo iso2 Q9JK11-2 Rtn4 rat S16 468313 LVSSSTDsPPRPPPA X +CDK2 CDK2 P24941 human Rb 5925 P06400 RB1 human S608 447976 tAADMyLsPVRsPKK X 2181; 8147 +CDK2 CDK2 P24941 human CCDC95 283899 Q8NBZ0 INO80E human S154 9831639 ALQLPEPsPLRPKRE X +CDK2 CDK2 P24941 human SCML2 10389 Q9UQR0 SCML2 human S267 3216606 AsQHsMQsPQKTTLI X +CDK2 CDK2 P24941 human LARP 23367 Q6PKG0 LARP1 human T303 4928285 yVPVAPPtPAWQPEI X +CDK2 CDK2 P24941 human SCML2 10389 Q9UQR0 SCML2 human S590 3216624 sPLVGDIsPKssPHE X +CDK2 CDK2 P24941 human Rb 5925 P06400 RB1 human S807 447980 PGGNIyIsPLksPyk Rb_C X X 9308; 8974; 4277; 40283; 8957; 8516; 11917; 99274; 41359; 75864; 72443 +CDK2 CDK2 P24941 human CCNE1 898 P24864 CCNE1 human S399 454414 GLLtPPQsGKKQSSG X X +CDK2 CDK2 P24941 human Rb-like 2 5934 Q08999 RBL2 human S1112 449743 LLEDGSEsPAKRICP X +CDK2 CDK2 P24941 human MLK3 4296 Q16584 MAP3K11 human S770 448612 LISRPRPsPLRsRID X X +CDK2 CDK2 P24941 human MCM7 4176 P33993 MCM7 human S121 3189844 RDPGMVRsPQNQYPA MCM_N X X +CDK2 CDK2 P24941 human BMZF-2 11176 Q9UIF9 BAZ2A human S509 9831628 AAAFPtAsPANKDVS X +CDK2 CDK2 P24941 human SRC-1 8648 Q15788 NCOA1 human S1279 18958507 PPASGYQsPDMKAWQ X +CDK2 CDK2 P24941 human TTK 7272 P33981 TTK human S436 950200 VFSVskQsPPIsTSk X +CDK2 CDK2 P24941 human TNRC15 26058 Q6Y7W6 GIGYF2 human S30 483131 sItsPPLsPALPkYk X +CDK2 CDK2 P24941 human Akt1 207 P31749 AKT1 human T479 8086741 FsysAsGtA______ X X +CDK2 CDK2 P24941 human MCM2 4171 P49736 MCM2 human S53 473058 LPPFEDEsEGLLGtE MCM2_N X +CDK2 CDK2 P24941 human AML1 iso8 861 Q01196-8 RUNX1 human S293 454400 QYLGSIAsPSVHPAt X +CDK2 CDK2 P24941 human KI-67 4288 P46013 MKI67 human S357 452301 QYsQQQNsPQkHKNk X +CDK2 CDK2 P24941 human MCM2 4171 P49736 MCM2 human S139 454180 RRGLLyDsDEEDEER MCM2_N X 8861; 12958 +CDK2 CDK2 P24941 human Tau iso8 4137 P10636-8 MAPT human T205 447933 ssPGsPGtPGsRsRt X 25377; 43964; 53001; 49561; 20060; 33032; 30505; 20739; 98160 +CDK2 CDK2 P24941 human TSR1 55720 Q2NL82 TSR1 human T490 9831781 MFPDEVDtPRDVAAR RIBIOP_C X +CDK2 CDK2 P24941 human ORC1L 4998 Q13415 ORC1 human S258 11002790 TSCAsLDsPGRIKRK X +CDK2 CDK2 P24941 human SRC-1 8648 Q15788 NCOA1 human T1026 18958512 GTMPVQVtPPrGAFs X +CDK2 CDK2 P24941 human CDC25C 398119 P30309 cdc25c-b frog T138 449911 LPRLLCStPSFKKTS M-inducer_phosp X +CDK2 CDK2 P24941 human RANGAP1 19387 P46061 Rangap1 mouse S444 449222 stFLsFPsPEKLLRL RanGAP1_C X +CDK2 CDK2 P24941 human SOX2 20674 P48432 Sox2 mouse S253 6738002 VksEASSsPPVVtSS X 92186 +CDK2 CDK2 P24941 human CCNE1 898 P24864 CCNE1 human S387 454413 LsEQNRAsPLPSGLL X +CDK2 CDK2 P24941 human B-Myb 17865 P48972 Mybl2 mouse T490 452027 SQKVVVTtPLHRDKt Cmyb_C X +CDK2 CDK2 P24941 human PXR 8856 O75469 NR1I2 human S167 30259802 KTFDTTFsHFkNFRL X +CDK2 CDK2 P24941 human CTNNB1 84353 Q9WU82 Ctnnb1 rat T41 447583 GIHsGATtTAPsLSG X 9561; 9565; 4270; 13537; 41334; 60180 +CDK2 CDK2 P24941 human ERAL1 26284 O75616 ERAL1 human S173 9831664 LDTPGIIsPGkQKRH MMR_HSR1 X +CDK2 CDK2 P24941 human Rb 5925 P06400 RB1 human S811 448717 IyIsPLksPykIsEG Rb_C X X 9308; 8974; 4277; 40283; 8957; 8516; 11917; 41359; 75864; 63276 +CDK2 CDK2 P24941 human EZH2 2146 Q15910 EZH2 human T345 4957354 LtAERIKtPPkRPGG X X 45153 +CDK2 CDK2 P24941 human NPAT 4863 Q14207 NPAT human T1350 2286401 ISRTTsAtPLkDNTQ NPAT_C X X +CDK2 CDK2 P24941 human MCM2 4171 P49736 MCM2 human S27 452310 GNDPLtssPGRssRR X +CDK2 CDK2 P24941 human hnRNP K 3190 P61978 HNRNPK human S216 450148 ILDLIsEsPIkGRAQ X X +CDK2 CDK2 P24941 human Kv-beta2 29738 P62483 Kcnab2 rat S9 486012 YPESTTGsPARLSLR X X +CDK2 CDK2 P24941 human PXR 8856 O75469 NR1I2 human T133 30259803 KRKKSERtGtQPLGV X +CDK2 CDK2 P24941 human GR 24413 P06536 Nr3c1 rat S232 447968 PSKDTNEsPWRSDLL GCR X +CDK2 CDK2 P24941 human Ebp1 5036 Q9UQ80 PA2G4 human S34 35542202 IANrVLRsLVEASSS Peptidase_M24 X +CDK2 CDK2 P24941 human B-Myb 4605 P10244 MYBL2 human T515 450110 QkYSMDNtPHtPtPF Cmyb_C X +CDK2 CDK2 P24941 human PR 5241 P06401 PGR human S294 447987 APMAPGRsPLATTVM Prog_receptor X 13736 +CDK2 CDK2 P24941 human ZC3H11A 9877 O75152 ZC3H11A human T321 3175981 PETNIDKtPKKAQVs X +CDK2 CDK2 P24941 human SIRT2 22933 Q8IXJ6 SIRT2 human S368 482809 PNPsTsAsPKKsPPP X X +CDK2 CDK2 P24941 human INCA1 388324 Q0VD86 INCA1 human S23 12524602 CSRVVSRsPPPRLPS INCA1 X +CDK2 CDK2 P24941 human hnRNP H2 3188 P55795 HNRNPH2 human S104 455396 LkHtGPNsPDtANDG X +CDK2 CDK2 P24941 human PMS1 227099 Q8K119 Pms1 mouse T311 36126893 AEVDINLtPDKSQVL DNA_mis_repair X +CDK2 CDK2 P24941 human FZR1 51343 Q9UM11 FZR1 human S151 467929 DVsPYSLsPVsNkSQ X +CDK2 CDK2 P24941 human gephyrin 64845 Q03555 Gphn rat S283 2020113 LSttPsEsPRAQAts X +CDK2 CDK2 P24941 human WRN 7486 Q14191 WRN human S426 3196115 YKSTEHLsPNDNEND X +CDK2 CDK2 P24941 human SLAIN2 57606 Q9P270 SLAIN2 human S48 468079 AGsLGPGsPVrAGAs X +CDK2 CDK2 P24941 human p53 7157 P04637 TP53 human S315 447530 LPNNtsssPQPkkkP X 2528 +CDK2 CDK2 P24941 human ER-alpha 2099 P03372 ESR1 human S341 33663900 TRPFSEAsMMGLLTN Hormone_recep X +CDK2 CDK2 P24941 human ILRUN 64771 Q9H6K1 ILRUN human S215 3244958 GNFNPFAsPQkNRQs X +CDK2 CDK2 P24941 human TANC1 85461 Q9C0D5 TANC1 human S1564 9831758 SSQNPPPsPMPGRIA X +CDK2 CDK2 P24941 human AKIRIN2 55122 Q53H80 AKIRIN2 human S18 485531 LDFDPLLsPAsPKRR X +CDK2 CDK2 P24941 human POLL 27343 Q9UGP5 POLL human S167 2025641 ALLQTALsPPPPPtR X +CDK2 CDK2 P24941 human ALDH5A1 7915 P51649 ALDH5A1 human T181 9831752 VyGDIIHtPAKDRRA Aldedh X +CDK2 CDK2 P24941 human H1E 3008 P10412 H1-4 human T18 467971 APAPAEktPVkKKAR X +CDK2 CDK2 P24941 human TOR1AIP1 26092 Q5JTV8 TOR1AIP1 human S143 3198371 EQPPLQPsPVMtRRG X +CDK2 CDK2 P24941 human MCM4 4173 P33991 MCM4 human S54 448667 ELQPMPtsPGVDLQs X +CDK2 CDK2 P24941 human CEP76 79959 Q8TAP6 CEP76 human S83 2048409 VEQELPssPkQPICF X X +Bmx Etk P97504 mouse Pim1 18712 P06803 Pim1 mouse Y218 451014 EWIRYHRyHGRSAAV Pkinase X +NLK NLK Q9UBE8 human SRC-3 8202 Q9Y6Q9 NCOA3 human S857 453084 PPYNRAVsLDsPVsV X +NLK NLK Q9UBE8 human LEF-1 51176 Q9UJU2 LEF1 human S166 11499000 tysDEHFsPGSHPSH CTNNB1_binding X X +NLK NLK Q9UBE8 human SMAD4 4089 Q13485 SMAD4 human S138 10238801 YHYERVVsPGIDLSG X +NLK NLK Q9UBE8 human TCF7L2 6934 Q9NQB0 TCF7L2 human T212 11499002 TYSNEHFtPGNPPPH CTNNB1_binding X X +NLK NLK Q9UBE8 human ER-alpha 2099 P03372 ESR1 human S104 448099 FPPLNsVsPsPLMLL Oest_recep X +NLK NLK Q9UBE8 human LEF-1 51176 Q9UJU2 LEF1 human S132 14160436 YMSNGSLsPPIPRTS CTNNB1_binding X +NLK NLK Q9UBE8 human LEF-1 51176 Q9UJU2 LEF1 human S200 3865992 IPtFyPLsPGGVGQI CTNNB1_binding X +NLK NLK Q9UBE8 human SRC-3 8202 Q9Y6Q9 NCOA3 human S860 454106 NRAVsLDsPVsVGss X +NLK NLK Q9UBE8 human SMAD2 4087 Q15796 SMAD2 human S250 448795 TGsPAELsPTTLsPV X X 3104 +NLK NLK Q9UBE8 human SRC-3 8202 Q9Y6Q9 NCOA3 human S543 454108 SLLSTLSsPGPKLDN NCOA_u2 X +NLK NLK Q9UBE8 human SMAD4 4089 Q13485 SMAD4 human T9 10238800 DNMSITNtPTSNDAC X +NLK NLK Q9UBE8 human YAP1 10413 P46937 YAP1 human S128 485035 QHVRAHssPAsLQLG X X +NLK NLK Q9UBE8 human FOXO1A 2308 Q12778 FOXO1 human S329 448076 stIsGRLsPIMtEQD X +NLK NLK Q9UBE8 human SRC-3 8202 Q9Y6Q9 NCOA3 human T24 454110 KRKLPCDtPGQGLtC X 2979 +NLK NLK Q9UBE8 human STAT3 20848 P42227 Stat3 mouse S727 448191 NtIDLPMsPRTLDSL X X 9134; 9136; 34911; 94994; 49081; 58978; 87544; 71958; 50804 +NLK NLK Q9UBE8 human TCF7L2 6934 Q9NQB0 TCF7L2 human T201 11499003 PHHVHPLtPLITYSN CTNNB1_binding X X +NLK NLK Q9UBE8 human ER-alpha 2099 P03372 ESR1 human S118 448101 LHPPPQLsPFLQPHG Oest_recep X 2511 +NLK NLK Q9UBE8 human SMAD3 4088 P84022 SMAD3 human S208 451179 DAGsPNLsPNPMsPA X X +NLK NLK Q9UBE8 human ER-alpha 2099 P03372 ESR1 human S106 448100 PLNsVsPsPLMLLHP Oest_recep X +NLK NLK Q9UBE8 human SRC-3 8202 Q9Y6Q9 NCOA3 human S867 454107 sPVsVGssPPVKNIS X +NLK NLK Q9UBE8 human ER-alpha 2099 P03372 ESR1 human S167 448102 GGRERLAsTNDkGSM Oest_recep X 64508; 42101 +NLK NLK Q9UBE8 human Raptor 57521 Q8N122 RPTOR human S863 453732 LtQsAPAsPtNkGVH X X +NLK NLK Q9UBE8 human YAP1 22601 P46938 Yap1 mouse S113 485035 QHVRAHssPAsLQLG X +NLK NLK Q9UBE8 human LEF-1 51176 Q9UJU2 LEF1 human T265 23053149 IPHPAIVtPQVKQEH X +NLK NLK Q9UBE8 human LEF-1 51176 Q9UJU2 LEF1 human T155 11499001 SHAVHPLtPLItysD CTNNB1_binding X X +NLK NLK Q9UBE8 human SRC-3 8202 Q9Y6Q9 NCOA3 human S505 454109 SPVAGVHsPMAsSGN NCOA_u2 X +TGM2 TGM2 P21980 human H3 8350 P68431 H3C1 human S10 455676 tkQtArkstGGkAPr Histone X 9701; 9711; 9606; 3465; 3642; 3377; 3475; 3458; 5764; 47398; 8481; 8552; 53348; 29237; 66065; 43185; 64522; 52725 +TGM2 TGM2 P21980 human H3 8350 P68431 H3C1 human S28 455677 ATkAArksAPATGGV Histone X 9713 +ALPK1 AlphaK3 Q96QP1 human TIFA 92610 Q96CG3 TIFA human T9 50409900 tSFEDADtEEtVTCL X X +Wnk4 WNK4 Q80UE6 mouse STLK3 53416 Q9Z1W9 Stk39 mouse T243 456505 tRNKVRKtFVGtPCW Pkinase X +Wnk4 WNK4 Q80UE6 mouse STLK3 53416 Q9Z1W9 Stk39 mouse S383 456506 VRRVPGssGHLHKTE X +Wnk4 WNK4 Q80UE6 mouse WNK4 69847 Q80UE6 Wnk4 mouse S1196 5879855 PGIMRRNsLSGSSTG X +ENPP3 ENPP3 O14638 human ENPP3 5169 O14638 ENPP3 human T205 3753305 RAMYPTKtFPNHYTI Phosphodiest X +Ret Ret P35546 mouse Ret 19713 P35546 Ret mouse Y1016 449894 MMVKSRDyLDLAAST X +Ret Ret P35546 mouse Ret 19713 P35546 Ret mouse Y1063 447625 TWIENKLyGMSDPNW X +Ret Ret P35546 mouse Ret 5979 P07949 RET human Y1062 447625 TWIENkLyGMsDPNW X +EEF2K EEF2K O00418 human EEF2 1938 P13639 EEF2 human T57 448040 rAGEtRFtDtRkDEQ GTP_EFTU X X 2331 +EEF2K EEF2K O00418 human EEF2K 29904 O00418 EEF2K human S396 450812 TFDsLPssPssAtPH X +EEF2K EEF2K O00418 human EEF2K 29904 O00418 EEF2K human S366 447827 sPQVRtLsGSRPPLL X 3691 +EEF2K EEF2K O00418 human EEF2 P55823 EEF2 rabbit T56 448040 RAGEtRFtDtRKDEQ GTP_EFTU X +EEF2K EEF2K O00418 human EEF2K 29904 O00418 EEF2K human S78 450687 ssGsPANsFHFkEAW X +EEF2K EEF2K O00418 human STAT3 6774 P40763 STAT3 human Y705 448192 DPGsAAPyLktKFIC X X 4093; 9145; 4324; 9131; 9138; 4323; 4074; 4113; 48313; 20977; 25023; 8119; 52075; 52527; 73533; 61958; 73452; 16185; 74309 +EEF2K EEF2K O00418 human GSK3B 2932 P49841 GSK3B human S9 449111 SGRPRttsFAEsCkP X X 9336; 9331; 9327; 9323; 9322; 9325; 5558; 8566; 79774; 8466; 25462; 14026; 14332; 14310; 14630 +EEF2K EEF2K O00418 human EEF2K 29904 O00418 EEF2K human S441 23101751 EsENsGDsGyPsEkR X +EEF2K EEF2K O00418 human EEF2K 29904 O00418 EEF2K human S500 455998 RLHLPRAsAVALEVQ X X +EEF2K EEF2K O00418 human EEF2K 29904 O00418 EEF2K human T348 3150902 kLLQsAktILRGtEE X X +EEF2K EEF2K O00418 human EEF2K 29904 O00418 EEF2K human T353 4696223 AktILRGtEEKCGsP X +EEF2K EEF2K O00418 human EEF2K 29904 O00418 EEF2K human S445 483529 sGDsGyPsEkRGELD X X +EEF2K EEF2K O00418 human EEF2K 29904 O00418 EEF2K human S474 3150890 kYEsDEDsLGssGRV X +EEF2K EEF2K O00418 human PKM 5315 P14618 PKM human T129 27110042 GLIkGsGtAEVELkk PK X X +EEF2K EEF2K O00418 human EEF2 P55823 EEF2 rabbit T53 466363 ASARAGEtRFtDtRK GTP_EFTU X +EEF2K EEF2K O00418 human EEF2 P55823 EEF2 rabbit T58 450254 GEtRFtDtRKDEQER GTP_EFTU X +EEF2K EEF2K O00418 human EEF2 13629 P58252 Eef2 mouse T57 448040 RAGEtRFtDtRKDEQ GTP_EFTU X 2331 +Limk1 LIMK1 P53669 rat Cofilin-1 29271 P45592 Cfl1 rat S3 448444 _____MAsGVAVsDG X X 3313; 3311 +Limk1 LIMK1 P53669 rat Cofilin-1 1072 P23528 CFL1 human S3 448444 _____MAsGVAVsDG X 3313; 3311 +Map2k3 MKK3 O09110 mouse MEKK3 26406 Q61084 Map3k3 mouse S526 458796 MSGTGIRsVTGTPYW Pkinase X +PRKG1 PKG1 Q13976 human GSK3B 84027 P18266 Gsk3b rat S9 449111 SGRPRTTsFAESCKP X 9336; 9331; 9327; 9323; 9322; 9325; 5558; 8566; 79774; 8466; 25462; 14026; 14332; 14310; 14630 +PRKG1 PKG1 Q13976 human TRPC7 26946 Q9WVC5 Trpc7 mouse T15 11164436 KNMQRRHtTLREKGR X X +PRKG1 PKG1 Q13976 human GATA4 2626 P43694 GATA4 human S262 450013 IkPQRRLsAsRRVGL X X +PRKG1 PKG1 Q13976 human PKAR1A 5573 P10644 PRKAR1A human S101 454354 RRRRGAIsAEVYTEE X X +PRKG1 PKG1 Q13976 human CACNA1C 100101555 P15381 CACB rabbit S1928 455278 ASLGRRAsFHLECLK CAC1F_C X +PRKG1 PKG1 Q13976 human SRF 6722 P11831 SRF human T159 449631 DNkLRRYtTFsKRkT SRF-TF X +PRKG1 PKG1 Q13976 human VASP 7408 P50552 VASP human T278 448381 LARRRKAtQVGEktP X X +PRKG1 PKG1 Q13976 human RGS4 100009014 Q0R4E4 RGS4 rabbit S52 469585 VVVCQRVsQEEVKKW X +PRKG1 PKG1 Q13976 human mGluR7 81672 P35400 Grm7 rat S862 2846504 NVQKRKRsFKAVVTA X +PRKG1 PKG1 Q13976 human TXA2-R iso2 6915 P21731-2 TBXA2R human T332 18790000 TRPRRsLtLWPSLEY X +PRKG1 PKG1 Q13976 human Titin 84015 XP_008773743 Ttn rat S3986 27842905 REQASLFsEWLRNID X +PRKG1 PKG1 Q13976 human CBS 875 P35520 CBS human S227 50301801 LDQYRNAsNPLAHYD PALP X X +PRKG1 PKG1 Q13976 human TRPC6 7225 Q9Y210 TRPC6 human T70 470868 RLAHRRQtVLREKGR X X +PRKG1 PKG1 Q13976 human H1R 3269 P35367 HRH1 human S398 450937 WKRLRsHsRQyVSGL 7tm_1 X +PRKG1 PKG1 Q13976 human RGS18 64407 Q9NS28 RGS18 human S216 4772683 PTNLRRRsRsFTCNE X +PRKG1 PKG1 Q13976 human TXA2-R iso2 6915 P21731-2 TBXA2R human S330 18790001 LSTRPRRsLtLWPSL X +PRKG1 PKG1 Q13976 human TNNI3 511094 P08057 TNNI3 cow S25 448424 PPVRRRssANYRAYA Troponin-I_N X +PRKG1 PKG1 Q13976 human RYR1 100009540 P11716 RYR1 rabbit S2843 451818 KKKTRKIsQTAQTYD X +PRKG1 PKG1 Q13976 human Titin 84015 XP_008773743 Ttn rat S3658 29618902 ETSARGLsVQAFDSE X +PRKG1 PKG1 Q13976 human ENSA 2029 O43768 ENSA human S109 477819 DLPQRkssLVtskLA Endosulfine X +PRKG1 PKG1 Q13976 human FHOD1 29109 Q9Y613 FHOD1 human S1131 451843 AARERKRsRGNRKsL X X +PRKG1 PKG1 Q13976 human GTF2I 2969 P78347 GTF2I human S784 457075 GVPFRRPstFGIPRL GTF2I X X +PRKG1 PKG1 Q13976 human ORAI1 84876 Q96D31 ORAI1 human S34 48990000 sRRsRRRsGDGEPPG X +PRKG1 PKG1 Q13976 human PPP1R14A 94274 Q96A00 PPP1R14A human T38 449098 QkRHARVtVkYDRRE PP1_inhibitor X +PRKG1 PKG1 Q13976 human TRPC3 iso3 7222 Q13507-3 TRPC3 human T11 458335 SPSLRRMtVMREKGR X X +PRKG1 PKG1 Q13976 human RAP1GAP2 23108 Q684P5 RAP1GAP2 human S7 455267 _MFGRKRsVsFGGFG X X +PRKG1 PKG1 Q13976 human CACNB2 100009277 P54288 CAB2 rabbit S522 486359 SGTSRGLsRQETFDS X +PRKG1 PKG1 Q13976 human PKD2 18764 O35245 Pkd2 mouse S827 4696848 HSSRRRGsIssGVsY X +PRKG1 PKG1 Q13976 human STMN1 3925 P16949 STMN1 human S63 448557 AAEERRksHEAEVLk Stathmin X +PRKG1 PKG1 Q13976 human IP3R1 25262 P29994 Itpr1 rat S1589 450681 RNAARRDsVLAASRD X +PRKG1 PKG1 Q13976 human SF1 117855 NP_001104263 Sf1 rat S20 449919 PSkKRKRsRWNQDTM SF1-HH X +PRKG1 PKG1 Q13976 human H2B 615043 P62808 H2BC19 cow S32 447801 DGKKRKRsRKEsYSV Histone X +PRKG1 PKG1 Q13976 human RGS2 5997 P41220 RGS2 human S46 10772900 kDWKTRLsYFLQNSS X X +PRKG1 PKG1 Q13976 human SSB 20823 P32067 Ssb mouse S199 2862901 KNEERKQsKVEAKLK X +PRKG1 PKG1 Q13976 human PKD2 18764 O35245 Pkd2 mouse T719 25690300 KLKLKRNtVDAISES X +PRKG1 PKG1 Q13976 human PDE5A 281972 Q28156 PDE5A cow S92 448178 GTPTRKIsASEFDRP X +PRKG1 PKG1 Q13976 human Titin 7273 Q8WZ42 TTN human S4099 27842905 sEQPGLFsEWLRNIE X +PRKG1 PKG1 Q13976 human MYBPC3 17868 O70468 Mybpc3 mouse S690 1877150010 VTQGKkAsAGPHPDA I-set X +PRKG1 PKG1 Q13976 human Titin 22138 A2ASS6 Ttn mouse S4080 27842905 REQANLFsEWLRNID X +PRKG1 PKG1 Q13976 human TXA2-R 6915 P21731 TBXA2R human S331 470029 sTRPRsLsLQPQLtQ X +PRKG1 PKG1 Q13976 human PKG1 5592 Q13976 PRKG1 human S65 51573802 TtRAQGIsAEPQTYR X X +PRKG1 PKG1 Q13976 human IP3R1 25262 P29994 Itpr1 rat S1756 450682 RPSGRREsLTSFGNG X 3760; 8548 +PRKG1 PKG1 Q13976 human GTF2I 2969 P78347 GTF2I human S412 457074 GIPFRRPstYGIPRL GTF2I X X +PRKG1 PKG1 Q13976 human RGS2 5997 P41220 RGS2 human S64 10772901 kPKTGKKsKQQAFIk X X +PRKG1 PKG1 Q13976 human MYPT1 396020 Q90623 PPP1R12A chicken S694 451998 QARQSRRstQGVTLT X +PRKG1 PKG1 Q13976 human VASP 22323 P70460 Vasp mouse S153 448379 EHMERRVsNAGGPPA X 3111; 84519 +PRKG1 PKG1 Q13976 human TRPC1 7220 P48995 TRPC1 human S206 35542201 SAKNKKDsLRHSRFR TRP_2 X +PRKG1 PKG1 Q13976 human URB 151887 Q76M96 CCDC80 human S434 28735102 PQTTRRPsKATSLES X +PRKG1 PKG1 Q13976 human H1R 3269 P35367 HRH1 human S396 453404 FTWKRLRsHsRQyVS 7tm_1 X +PRKG1 PKG1 Q13976 human ARPP-19 10776 P56211 ARPP19 human S104 477874 DLPQRkPsLVAskLA Endosulfine X +PRKG1 PKG1 Q13976 human URB 151887 Q76M96 CCDC80 human S409 23071314 VITARRPsVsENLYP X +PRKG1 PKG1 Q13976 human PDE5A 8654 O76074 PDE5A human S102 448178 GTPTRKIsAsEFDRP X +PRKG1 PKG1 Q13976 human VASP 7408 P50552 VASP human S239 448380 GAKLRKVsKQEEASG X X 3114; 37565 +PRKG1 PKG1 Q13976 human RAP1B 5908 P61224 RAP1B human S179 451799 PGkARKKsscQLL__ X +PRKG1 PKG1 Q13976 human smMLCK 100009143 P29294 MYLK rabbit S1005 455821 GLSGRKSsTGSPTsP X +PRKG1 PKG1 Q13976 human BAD 12015 Q61337 Bad mouse S155 447863 GRELRRMsDEFEGsF Bcl-2_BAD X 9297 +PRKG1 PKG1 Q13976 human RHOA 387 P61586 RHOA human S188 449035 ARRGKKKsGCLVL__ X +PRKG1 PKG1 Q13976 human TNNI3 511094 P08057 TNNI3 cow S24 448423 PPPVRRRssANYRAY Troponin-I_N X +PRKG1 PKG1 Q13976 human TRPC6 22068 Q61143 Trpc6 mouse T69 470868 RLTHRRQtILREKGR X X +PRKG1 PKG1 Q13976 human PFKM 100345647 P00511 PFKM rabbit S775 458322 EHISRKRsGEATV__ X +PRKG1 PKG1 Q13976 human MYPT1 116670 Q10728 Ppp1r12a rat S696 451998 QARQSRRstQGVTLT X +PRKG1 PKG1 Q13976 human H1C 513971 P02253 H1-2 cow S36 450120 AGARRKAsGPPVSEL X +PRKG1 PKG1 Q13976 human Lasp-1 3927 Q14847 LASP1 human S146 448836 MEPERRDsQDGssyR X +PRKG1 PKG1 Q13976 human TRPC6 7225 Q9Y210 TRPC6 human S322 3363401 KNDYKKLsMQCKDFV X +PRKG1 PKG1 Q13976 human Titin 7273 Q8WZ42 TTN human S4185 5474103 IQQGAKtsLQEEMDs X +PRKG1 PKG1 Q13976 human VASP 22323 P70460 Vasp mouse S235 448380 GAKLRKVsKQEEASG X 3114; 37565 +PRKG1 PKG1 Q13976 human HSL 3991 Q05469 LIPE human S853 448803 IAEPMRRsVsEAALA X 4139 +PRKG1 PKG1 Q13976 human RYR2 20191 E9Q401 Ryr2 mouse S2807 448848 YNRTRRIsQtsQVsI X +PRKG1 PKG1 Q13976 human MLK3 26403 Q80XI6 Map3k11 mouse T278 448263 LAREWHKtTQMsAAG PK_Tyr_Ser-Thr X X +PRKG1 PKG1 Q13976 human PDE3A 54611 Q9Z0X4 Pde3a mouse S654 36132073 REPQRKAsACGTYTS X +PRKG1 PKG1 Q13976 human TSC2 7249 P49815 TSC2 human S1364 471941 IPIERVVssEGGRPs X +PRKG1 PKG1 Q13976 human TRPC1 7220 P48995 TRPC1 human T347 35542200 SGYRRKPtCKKIMTV X +PRKG1 PKG1 Q13976 human MYPT1 396020 Q90623 PPP1R12A chicken S667 478658 EVRERRRsYLTPVRD X 3048 +PRKG1 PKG1 Q13976 human GUCY1A1 497757 P19686 Gucy1a1 rat S64 3647001 SHPQRKTsRNRVYLH X +PRKG1 PKG1 Q13976 human GTF2I iso2 2969 P78347-2 GTF2I human S743 457075 GVPFRRPstFGIPRL GTF2I X +PRKG1 PKG1 Q13976 human SERT 6532 P31645 SLC6A4 human T276 456508 SIWKGVKtsGKVVWV SNF X X +PRKG1 PKG1 Q13976 human MYPT1 116670 Q10728 Ppp1r12a rat T697 448587 ARQSRRstQGVTLTD X 5163 +PRKG1 PKG1 Q13976 human MLK3 26403 Q80XI6 Map3k11 mouse S282 448262 WHKtTQMsAAGTYAW PK_Tyr_Ser-Thr X X +PRKG1 PKG1 Q13976 human KCNMA1 403984 Q28265 KCNMA1 dog S1084 466425 QSSSKKSsSVHSIPS X +PRKG1 PKG1 Q13976 human Titin 7273 Q8WZ42 TTN human S4092 29618901 ALQAAVAsEQPGLFs X +PRKG1 PKG1 Q13976 human TRPC3 7222 Q13507 TRPC3 human S336 458336 KNDYRKLsMQCKDFV X X +PRKG1 PKG1 Q13976 human PTS 5805 Q03393 PTS human S19 450662 AQVSRRIsFSASHRL PTPS X +PRKG1 PKG1 Q13976 human CBS 875 P35520 CBS human S525 50301802 YHSTGKSsQRQMVFG X X +PRKG1 PKG1 Q13976 human ARHGEF6 9459 Q15052 ARHGEF6 human S684 456737 GSSTRkDsIPQVLLP X +PRKG1 PKG1 Q13976 human Titin 7273 Q8WZ42 TTN human S4010 27842904 VRIEEGKsLRFPLAL X +PRKG1 PKG1 Q13976 human PFKM 100345647 P00511 PFKM rabbit S377 4707523 AMKLRGRsFMNNWEV X +PRKG1 PKG1 Q13976 human VASP 7408 P50552 VASP human S157 448379 EHIERRVsNAGGPPA X X 3111; 84519 +PRKG1 PKG1 Q13976 human Titin 7273 Q8WZ42 TTN human S11878 10029600 KEEVVLKsVLRKRPE X +PRKG1 PKG1 Q13976 human GTF2I iso2 2969 P78347-2 GTF2I human S371 457074 GIPFRRPsTYGIPRL GTF2I X +MAPK1 ERK2 P28482 human HELLS 3070 Q9NRZ9 HELLS human S503 9764950 EKEtIELsPtGRPKR SNF2-rel_dom X X +MAPK1 ERK2 P28482 human BRAF 673 P15056 BRAF human T401 452246 sTtGLsAtPPAsLPG X +MAPK1 ERK2 P28482 human Tau iso8 4137 P10636-8 MAPT human T231 449079 KKVAVVRtPPKsPss X 20473; 71429 +MAPK1 ERK2 P28482 human WTAP 9589 Q15007 WTAP human S341 3196721 AGYESVDsPtGsENs X X +MAPK1 ERK2 P28482 human NHE1 6548 P19634 SLC9A1 human S726 2509107 IDPAsPQsPEsVDLV X +MAPK1 ERK2 P28482 human SMAD4 17128 P97471 Smad4 mouse S367 1877718910 RFCLGQLsNVHRTEA MH2 X X +MAPK1 ERK2 P28482 human CRYAB 25420 P23928 Cryab rat S45 448748 FSTATSLsPFYLRPP Crystallin X +MAPK1 ERK2 P28482 human Kir6.2 16514 Q61743 Kcnj11 mouse S385 2103601 AKPKFSIsPDsLS__ X +MAPK1 ERK2 P28482 human NUP153 9972 P49790 NUP153 human T388 3191107 VyFkPsLtPsGEFRK Nup153 X X +MAPK1 ERK2 P28482 human IRS1 3667 P35568 IRS1 human S636 447506 sGDyMPMsPKsVSAP X 2388 +MAPK1 ERK2 P28482 human Fe65 322 O00213 APBB1 human T709 451149 PKRLGAHtP______ X X +MAPK1 ERK2 P28482 human PXN iso2 5829 P49023-2 PXN human S83 451113 FIHQQPQsssPVyGs Paxillin X +MAPK1 ERK2 P28482 human p90RSK 81771 Q63531 Rps6ka1 rat T359 447992 DTEFTSRtPRDsPGI Pkinase_C X 9344 +MAPK1 ERK2 P28482 human p90RSK 6195 Q15418 RPS6KA1 human T573 447993 AENGLLMtPCytANF Pkinase X 9346 +MAPK1 ERK2 P28482 human KLC1 171041 P37285 Klc1 rat S460 477826 YKACKVDsPTVTTTL X +MAPK1 ERK2 P28482 human Tau iso8 4137 P10636-8 MAPT human S199 447927 GDRsGyssPGsPGtP X X 29957 +MAPK1 ERK2 P28482 human FGFR2 2263 P21802 FGFR2 human S780 34500854 SQPLEQYsPsYPDTR X +MAPK1 ERK2 P28482 human SHARPIN 81858 Q9H0F6 SHARPIN human S146 31883820 ACPVsLPsPPEAStL X X +MAPK1 ERK2 P28482 human NPAS4 225872 Q8BGD7 Npas4 mouse S580 1871095702 KLPPsPSsPGNGDCT X +MAPK1 ERK2 P28482 human TH iso2 7054 P07101-2 TH human S58 448544 SYTPTPRsPRFIGRR TOH_N X +MAPK1 ERK2 P28482 human DET1 76375 Q9D0A0 Det1 mouse S66 63280109 PCFLRKFsPDGRYFI X +MAPK1 ERK2 P28482 human SPHK1 8877 Q9NYA1 SPHK1 human S225 460682 VGSKTPAsPVVVQQG X X +MAPK1 ERK2 P28482 human ATF-2 1386 P15336 ATF2 human T71 448225 IVADQtPtPtRFLkN X X 9225; 9221; 5112; 94125; 13850; 40749; 15411; 24329; 61584; 27934; 92109; 20534; 35858 +MAPK1 ERK2 P28482 human p70S6K 6198 P23443 RPS6KB1 human S447 448357 GsPRtPVsPVkFsPG X 9204 +MAPK1 ERK2 P28482 human PDE4B 5142 Q07343 PDE4B human S659 471380 YQSMIPQsPSPPLDE X +MAPK1 ERK2 P28482 human GRASP55 26003 Q9H8Y8 GORASP2 human T222 470124 LPGQMAGtPItPLKD X +MAPK1 ERK2 P28482 human PARVA 55742 Q9NVD7 PARVA human S4 4270096 ____MAtsPQKsPsV X +MAPK1 ERK2 P28482 human TACE 6868 P78536 ADAM17 human T735 449804 kPFPAPQtPGRLQPA X X +MAPK1 ERK2 P28482 human SMAD1 4086 Q15797 SMAD1 human S195 451174 PNSSYPNsPGSSSSt X +MAPK1 ERK2 P28482 human REST 5978 Q13127 REST human S861 36320700 sVsTEDLsPPsPPLP X X +MAPK1 ERK2 P28482 human SMAD1 4086 Q15797 SMAD1 human S187 451173 NSHPFPHsPNSSYPN X +MAPK1 ERK2 P28482 human STIM1 6786 Q13586 STIM1 human S608 3195758 PsAPPGGsPHLDSSR X +MAPK1 ERK2 P28482 human TOB1 10140 P50616 TOB1 human S154 455536 SSVSSsPsPPFGHSA X X +MAPK1 ERK2 P28482 human TSC2 7249 P49815 TSC2 human S664 455575 KkTSGPLsPPTGPPG Tuberin X 40729 +MAPK1 ERK2 P28482 human Bcl-2 596 P10415 BCL2 human T74 448632 ARtsPLQtPAAPGAA X +MAPK1 ERK2 P28482 human NPAS4 225872 Q8BGD7 Npas4 mouse T427 1869686800 LVCTPPYtPHQPGGC X +MAPK1 ERK2 P28482 human ASL 435 P04424 ASL human S417 1880040200 LQELQTIsPLFSGDV X X +MAPK1 ERK2 P28482 human p70S6K 83840 P67999 Rps6kb1 rat S447 448357 GsPRtPVsPVKFsPG X 9204 +MAPK1 ERK2 P28482 human PXN iso2 5829 P49023-2 PXN human S126 450227 sFPNKQKsAEPsPtV Paxillin X +MAPK1 ERK2 P28482 human DUSP16 80824 Q9BY84 DUSP16 human S446 449606 TNKLCQFsPVQELSE X +MAPK1 ERK2 P28482 human PSD-95 29495 P31016 Dlg4 rat T287 469607 TDyPtAMtPTsPRRY PDZ_assoc X +MAPK1 ERK2 P28482 human MITF iso9 4286 O75030-9 MITF human S73 450264 PGSSAPNsPMAMLTL MITF_TFEB_C_3_N X X +MAPK1 ERK2 P28482 human ELK1 13712 P41969 Elk1 mouse T354 22725900 QAPGPALtPSLLPTH X +MAPK1 ERK2 P28482 human PARP1 142 P09874 PARP1 human S372 463804 VAAtPPPstAsAPAA X +MAPK1 ERK2 P28482 human MTMR2 8898 Q13614 MTMR2 human S58 3195800 StSADNFsPDLRVLR X X +MAPK1 ERK2 P28482 human ELK1 13712 P41969 Elk1 mouse S390 449757 LsPIAPRsPAKLSFQ X +MAPK1 ERK2 P28482 human KLF8 11279 O95600 KLF8 human S48 56672701 EYRSNMTsPTLLDAN X +MAPK1 ERK2 P28482 human TORC3 64784 Q6UUV7 CRTC3 human S391 3203130 RRRQPPVsPLtLsPG X +MAPK1 ERK2 P28482 human DRP1 74006 Q8K1M6 Dnm1l mouse S622 454690 PIPIMPAsPQKGHAV X 3455; 4494; 63940 +MAPK1 ERK2 P28482 human WTAP 9589 Q15007 WTAP human S306 453808 tEDDFPssPGNGNKs X +MAPK1 ERK2 P28482 human p300 2033 Q09472 EP300 human T1960 486261 QHQMPPMtPMAPMGM X +MAPK1 ERK2 P28482 human STMN3 50861 Q9NZ72 STMN3 human S68 454282 PSDLsPEsPMLssPP Stathmin X +MAPK1 ERK2 P28482 human RBM17 84991 Q96I25 RBM17 human S222 3209223 EEQDRPRsPtGPsNs X X +MAPK1 ERK2 P28482 human JunD 16478 P15066 Jund mouse S90 473544 APDGLLAsPDLGLLK Jun X +MAPK1 ERK2 P28482 human LYL1 4066 P12980 LYL1 human S36 15624701 APPPKPAsPGPPQVE X +MAPK1 ERK2 P28482 human NIPA 232679 Q80YV2 Zc3hc1 mouse S353 449745 PIVsRtRsWEsssPV X +MAPK1 ERK2 P28482 human SP1 6667 P08047 SP1 human S59 452233 GGQEsQPsPLALLAA X X +MAPK1 ERK2 P28482 human RAGE 11596 Q62151 Ager mouse S376 4731271 EERKAPEsQEDEEER X +MAPK1 ERK2 P28482 human DUSP5 1847 Q16690 DUSP5 human S346 10206800 IGHLQTLsPDMQGAY X +MAPK1 ERK2 P28482 human CASP9 842 P55211 CASP9 human T125 449563 PEVLRPEtPRPVDIG X X +MAPK1 ERK2 P28482 human DUSP6 1848 Q16828 DUSP6 human S159 455265 DGSCSSSsPPLPVLG X X +MAPK1 ERK2 P28482 human WAVE2 10163 Q9Y6W5 WASF2 human S308 12626400 PPAPPLGsPPGPKPG X +MAPK1 ERK2 P28482 human SRC-1 8648 Q15788 NCOA1 human T1179 449063 NYGTNPGtPPASTsP DUF1518 X +MAPK1 ERK2 P28482 human ER-alpha 2099 P03372 ESR1 human S104 448099 FPPLNsVsPsPLMLL Oest_recep X X +MAPK1 ERK2 P28482 human NCAM1 iso1 4684 P13591-1 NCAM1 human T803 15721468 HTEPNETtPLTEPEK X +MAPK1 ERK2 P28482 human PSD-93 64053 Q63622 Dlg2 rat S323 472024 KTSLPPIsPGRysPI PDZ_assoc X +MAPK1 ERK2 P28482 human STIM1 6786 Q13586 STIM1 human S575 468876 LVEKLPDsPALAKkA X X +MAPK1 ERK2 P28482 human PKM 18746 P52480 Pkm mouse S37 476070 MCRLDIDsAPItARN X +MAPK1 ERK2 P28482 human CENPE 1062 Q02224 CENPE human S2654 459191 sRsKsLPsPHPVRYF X +MAPK1 ERK2 P28482 human CTNND1 1500 O60716 CTNND1 human T906 469141 sLDNNystPNERGDH X +MAPK1 ERK2 P28482 human CBP 1387 Q92793 CREBBP human S93 20615901 IGNVSASsPVQQGLG X +MAPK1 ERK2 P28482 human ARRB2 409 P32121 ARRB2 human S14 23083983 TRVFKKssPNCKLtV X +MAPK1 ERK2 P28482 human AML1 iso8 861 Q01196-8 RUNX1 human S276 454399 DTRQIQPsPPWSYDQ X +MAPK1 ERK2 P28482 human Oct4 5460 Q01860 POU5F1 human T118 25236706 sPEPCtVtPGAVkLE X +MAPK1 ERK2 P28482 human RGS19 10287 P49795 RGS19 human S151 447873 EDyVsILsPkEVSLD RGS X X +MAPK1 ERK2 P28482 human CACNB1 50688 P54283 Cacnb1 rat S348 459046 IVYIKITsPKVLQRL Guanylate_kin X +MAPK1 ERK2 P28482 human MAFA 389692 Q8NHW3 MAFA human S14 1713900 MGAELPSsPLAIEYV X X +MAPK1 ERK2 P28482 human NG2 81651 Q00657 Cspg4 rat T2314 483998 ELLQFCRtPNPALRN X +MAPK1 ERK2 P28482 human FRA2 14284 P47930 Fosl2 mouse T322 14573760 SDSLNsPtLLAL___ X +MAPK1 ERK2 P28482 human Fos 2353 P01100 FOS human S374 448482 PSSDSLSsPtLLAL_ X +MAPK1 ERK2 P28482 human JAK2 16452 Q62120 Jak2 mouse S523 465671 GISDVQIsPtLQRHN X +MAPK1 ERK2 P28482 human MCR 4306 P08235 NR3C2 human S196 25692901 EKSPSVCsPLNMTSS X +MAPK1 ERK2 P28482 human Abi-1 10006 Q8IZP0 ABI1 human S410 12626407 DIPMFDDsPPPPPPP X +MAPK1 ERK2 P28482 human NUP214 8021 P35658 NUP214 human S1809 10296401 NAPAFGQsPGFGQGG X +MAPK1 ERK2 P28482 human ELK1 13712 P41969 Elk1 mouse T337 2751400 GGQGPERtPGSGTSS X +MAPK1 ERK2 P28482 human SMAD2 4087 Q15796 SMAD2 human S255 448796 ELsPTTLsPVNHsLD X 3104 +MAPK1 ERK2 P28482 human TOP2A 7153 P11388 TOP2A human S1247 452238 kNENtEGsPQEDGVE X +MAPK1 ERK2 P28482 human Fos 2353 P01100 FOS human T232 448491 GGLPEVAtPESEEAF X +MAPK1 ERK2 P28482 human ELK1 13712 P41969 Elk1 mouse T369 22725901 TLtPVLLtPSSLPPS X +MAPK1 ERK2 P28482 human p67phox 4688 P19878 NCF2 human T233 457386 EPPPRPKtPEIFRAL X +MAPK1 ERK2 P28482 human PDX1 3651 P52945 PDX1 human S66 458402 QGsPPDIsPYEVPPL X +MAPK1 ERK2 P28482 human RBPMS 19663 Q9WVB0 Rbpms mouse T113 3208557 AKNKLVGtPNPstPL X X +MAPK1 ERK2 P28482 human DUSP1 1843 P28562 DUSP1 human S323 457718 HCSAEAGsPAMAVLD X X +MAPK1 ERK2 P28482 human PKR 5610 P19525 EIF2AK2 human T451 448089 kRtRSKGtLRyMsPE Pkinase X +MAPK1 ERK2 P28482 human TAGLN2 8407 P37802 TAGLN2 human S145 31885453 ArDDGLFsGDPNWFP X X +MAPK1 ERK2 P28482 human PML iso4 5371 P29590-4 PML human T28 451468 PTMPPPEtPSEGRQP X X +MAPK1 ERK2 P28482 human eNOS 4846 P29474 NOS3 human S600 34729904 MSGPYNSsPRPEQHK Flavodoxin_1 X X +MAPK1 ERK2 P28482 human PITPNM1 9600 O00562 PITPNM1 human T1223 451457 AEREGPGtPPTTLAr X +MAPK1 ERK2 P28482 human GLE1 2733 Q53GS7 GLE1 human S99 18010022 ssAFsPAsPAtPNGT X +MAPK1 ERK2 P28482 human GLI1 2735 P08151 GLI1 human S116 1877717202 FINSRCTsPGGSYGH X +MAPK1 ERK2 P28482 human RORC 6097 P51449 RORC human S205 4708350 ASCHLEYsPERGKAE X X +MAPK1 ERK2 P28482 human RSK2 110651 P18654 Rps6ka3 mouse T577 450152 AENGLLMtPCYtANF Pkinase X +MAPK1 ERK2 P28482 human Fe65 322 O00213 APBB1 human S175 451146 EEEEDLSsPPGLPEP X X +MAPK1 ERK2 P28482 human PPAR-gamma 19016 P37238 Pparg mouse S273 15175800 TGkTTDKsPFVIYDM X X +MAPK1 ERK2 P28482 human JunD 16478 P15066 Jund mouse S100 456168 LGLLKLAsPELERLI Jun X 9164 +MAPK1 ERK2 P28482 human Fe65 322 O00213 APBB1 human S347 451148 TFPAQSLsPEPLPQE X X +MAPK1 ERK2 P28482 human FHOD1 29109 Q9Y613 FHOD1 human S498 1984218 PAARtPQsPAPCVLL X +MAPK1 ERK2 P28482 human AML1 iso8 861 Q01196-8 RUNX1 human T300 454403 sPSVHPAtPIsPGRA X +MAPK1 ERK2 P28482 human Raptor 57521 Q8N122 RPTOR human S696 11315003 EKNyALPsPAttEGG X X +MAPK1 ERK2 P28482 human Tau iso8 4137 P10636-8 MAPT human S396 449081 GAEIVyKsPVVsGDt X X 9632 +MAPK1 ERK2 P28482 human ARRB1 408 P49407 ARRB1 human S412 447493 EEEDGtGsPQLNNR_ X X 2416 +MAPK1 ERK2 P28482 human DUSP6 1848 Q16828 DUSP6 human S197 455266 SATDSDGsPLSNSQP X X +MAPK1 ERK2 P28482 human p300 328572 B2RWS6 Ep300 mouse S2276 486262 PAQPNPMsPQQHMLP X X +MAPK1 ERK2 P28482 human SERT 6532 P31645 SLC6A4 human T616 7576402 IKsItPEtPTEIPCG X +MAPK1 ERK2 P28482 human eNOS 287024 P29473 NOS3 cow S116 448638 RKLQTRPsPGPPPAE X 9575 +MAPK1 ERK2 P28482 human CIITA 4261 P33076 CIITA human S280 471421 TVHGLPTsPDRPGsT X X +MAPK1 ERK2 P28482 human 4E-BP1 116636 Q62622 Eif4ebp1 rat S64 447527 FLMECRNsPVAKtPP eIF_4EBP X 9451; 9456 +MAPK1 ERK2 P28482 human Tau iso8 4137 P10636-8 MAPT human S404 449082 PVVsGDtsPRHLsNV X 35834; 20194; 98523; 91600; 49562 +MAPK1 ERK2 P28482 human TNF-R1 21937 P25118 Tnfrsf1a mouse S291 25573802 FStPGFSsPVSStPI X +MAPK1 ERK2 P28482 human smMLCK 100009143 P29294 MYLK rabbit S1011 468782 SsTGSPTsPLTAERL X +MAPK1 ERK2 P28482 human MAPKAPK2 9261 P49137 MAPKAPK2 human S272 448268 SNHGLAIsPGMKTRI Pkinase X +MAPK1 ERK2 P28482 human SRC-1 8648 Q15788 NCOA1 human S1185 449064 GtPPASTsPFSQLAA DUF1518 X +MAPK1 ERK2 P28482 human TPD52 7163 P55327 TPD52 human S40 17555377 GNssPPGsPTLQKFG X X +MAPK1 ERK2 P28482 human PPAR-gamma 5468 P37231 PPARG human S112 448062 AIkVEPAsPPYYSEK X +MAPK1 ERK2 P28482 human Fos 314322 P12841 Fos rat T331 448484 CtPVVTCtPSCTTYT X +MAPK1 ERK2 P28482 human BIM 10018 O43521 BCL2L11 human S69 449330 GPLAPPAsPGPFATR X X 4581; 4585 +MAPK1 ERK2 P28482 human MCTS1 28985 Q9ULC4 MCTS1 human T81 26348501 REGPFYPtLRLLHkY Pre-PUA X +MAPK1 ERK2 P28482 human hnRNP E2 5094 Q15366 PCBP2 human S272 482918 FsGIEsssPEVkGyW X X +MAPK1 ERK2 P28482 human PDE4D iso5 5144 Q08499-5 PDE4D human S413 451090 YQSTIPQsPSPAPDD X X +MAPK1 ERK2 P28482 human HePTP 5778 P35236 PTPN7 human S93 448310 ALQRQPPsPKQLEEE X +MAPK1 ERK2 P28482 human ER-beta 13983 O08537 Esr2 mouse S87 447915 WPTSGHLsPLATHCQ ERbeta_N X +MAPK1 ERK2 P28482 human BANP 54971 Q8N9N5 BANP human T337 41301700 VkSFSRRtPNSSSYC X +MAPK1 ERK2 P28482 human SYN1 24949 P09951 Syn1 rat S62 451572 stAAPVAsPAAPsPG X +MAPK1 ERK2 P28482 human NCAM-L1 3897 P32004 L1CAM human S1204 472276 GDIKPLGsDDSLADy Bravo_FIGEY X +MAPK1 ERK2 P28482 human eIF2B-epsilon 192234 Q64350 Eif2b5 rat S539 449906 ELDsRAGsPQLDDIR X +MAPK1 ERK2 P28482 human Tau iso8 4137 P10636-8 MAPT human S262 447930 NVKskIGstENLkHQ Tubulin-binding X +MAPK1 ERK2 P28482 human BTG2 12227 Q04211 Btg2 mouse S147 455911 QMMLGRSsPsKNYVM X +MAPK1 ERK2 P28482 human CCNB1 891 P14635 CCNB1 human S126 448814 PILVDTAsPsPMETs X +MAPK1 ERK2 P28482 human p300 2033 Q09472 EP300 human S2279 486262 PVQPNPMsPQQHMLP X X +MAPK1 ERK2 P28482 human NANOG 79923 Q9H9S0 NANOG human S52 31960309 MPHTEtVsPLPssMD X +MAPK1 ERK2 P28482 human Trap170 9282 O60244 MED14 human S986 452549 NEDDNPPsPIGGDMM X +MAPK1 ERK2 P28482 human ELK1 13712 P41969 Elk1 mouse S423 469193 LStPVVLsPGPQKP_ X +MAPK1 ERK2 P28482 human hnRNP K 3190 P61978 HNRNPK human S284 448185 rrDyDDMsPrrGPPP X +MAPK1 ERK2 P28482 human TPPP 11076 O94811 TPPP human S18 456612 ANRtPPKsPGDPskD X +MAPK1 ERK2 P28482 human NFL 4747 P07196 NEFL human T21 2872004 ykRRYVEtPrVHISS Filament_head X +MAPK1 ERK2 P28482 human eNOS 287024 P29473 NOS3 cow S602 34729904 MSGPYNSsPRPEQHK Flavodoxin_1 X +MAPK1 ERK2 P28482 human FOXO3A 2309 O43524 FOXO3 human S294 472326 QLskWPGsPtsRsSD X X 5538 +MAPK1 ERK2 P28482 human NEUROD1 18012 Q60867 Neurod1 mouse S162 465677 EILRSGKsPDLVSFV Neuro_bHLH X +MAPK1 ERK2 P28482 human SHARPIN 81858 Q9H0F6 SHARPIN human T309 1879811806 APREAPAtGPsPQHP X +MAPK1 ERK2 P28482 human TORC2 200186 Q53ET0 CRTC2 human S238 1870757301 DAkKLSSsSSRPRsC TORC_M X +MAPK1 ERK2 P28482 human Fos 14281 P01101 Fos mouse S32 470080 DSLSYYHsPADSFSS X 5348; 8709; 8677; 99325 +MAPK1 ERK2 P28482 human MEK1 5604 Q02750 MAP2K1 human T292 448287 EtPPRPRtPGRPLss Pkinase X X 26975 +MAPK1 ERK2 P28482 human eNOS 287024 P29473 NOS3 cow T46 34729903 SRAPAPAtPHAPDHS X +MAPK1 ERK2 P28482 human ADRB3 11556 P25962 Adrb3 mouse S247 40508998 GRFsPEEsPPsPSRS 7tm_1 X +MAPK1 ERK2 P28482 human Kv4.2 Q63881 Kcnd2 rat S616 457613 EGDDRPEsPEYSGGN X +MAPK1 ERK2 P28482 human TH 7054 P07101 TH human S62 448544 SYTPTPRsPRFIGRR TOH_N X +MAPK1 ERK2 P28482 human ASB2 51676 Q96Q27 ASB2 human S371 29618900 RIRRSGVsPLHLAAE Ank_2 X +MAPK1 ERK2 P28482 human FRA2 2355 P15408 FOSL2 human T322 14573760 SDsLNsPtLLAL___ X +MAPK1 ERK2 P28482 human CK2A1 1457 P68400 CSNK2A1 human S362 449986 ISSVPtPsPLGPLAG X X +MAPK1 ERK2 P28482 human PIAS1 300772 A9UK05 Pias1 rat S503 3177703 LSLPHQAsPVSRTPS X +MAPK1 ERK2 P28482 human CAD 101843763 P08955 Cad hamster T456 451248 KVYFLPItPHYVTQV X +MAPK1 ERK2 P28482 human NUP50 10762 Q9UKX7 NUP50 human S315 4957816 TQSkPVSsPFPTkPL X X +MAPK1 ERK2 P28482 human BRAF 673 P15056 BRAF human T753 460657 yACAsPKtPIQAGGy X +MAPK1 ERK2 P28482 human PDE4C iso2 5143 Q08493-2 PDE4C human S535 471381 YQSKIPRsPSDLTNP X +MAPK1 ERK2 P28482 human PML iso4 5371 P29590-4 PML human S527 451472 PHLDGPPsPRsPVIG DUF3583 X X +MAPK1 ERK2 P28482 human NDEL1 81565 Q9GZM8 NDEL1 human T219 468252 AsLsLPAtPVGKGTE NUDE_C X +MAPK1 ERK2 P28482 human smMLCK 4638 Q15746 MYLK human S1779 468782 sstGsPtsPLNAEKL X +MAPK1 ERK2 P28482 human capicua 23152 Q96RK0 CIC human S1389 4952030 sPRAILGsYRKKRKN X +MAPK1 ERK2 P28482 human SP3 6670 Q02447 SP3 human S73 1199100 CsKIGPPsPGDDEEE X X +MAPK1 ERK2 P28482 human KIBRA 23286 Q8IX03 WWC1 human S548 30312500 SsPSPPCsPLMADPL X X +MAPK1 ERK2 P28482 human FGFR1 2260 P11362 FGFR1 human S777 2721300 SMPLDQysPsFPDTR X +MAPK1 ERK2 P28482 human GSK3B 2932 P49841 GSK3B human T43 456221 kVTTVVAtPGQGPDR X +MAPK1 ERK2 P28482 human Lck 3932 P06239 LCK human S59 447820 EGSNPPAsPLQDNLV X +MAPK1 ERK2 P28482 human LIFR 3977 P42702 LIFR human S1044 450385 WNLVsPDsPRsIDSN X X +MAPK1 ERK2 P28482 human Cortactin 2017 Q14247 CTTN human S405 447700 KtQtPPVsPAPQPtE X X +MAPK1 ERK2 P28482 human RRas2 22800 P62070 RRAS2 human S186 484150 QEQECPPsPEPtRkE X +MAPK1 ERK2 P28482 human PDE4D iso2 5144 Q08499-2 PDE4D human S579 451090 YQSTIPQsPSPAPDD X X +MAPK1 ERK2 P28482 human SHARPIN 81858 Q9H0F6 SHARPIN human S165 3245774 PEADLPRsPGNLtER X +MAPK1 ERK2 P28482 human IP3R1 16438 P11881 Itpr1 mouse S436 469626 AFAIVPVsPAEVRDL X X +MAPK1 ERK2 P28482 human TFAM 7019 Q00059 TFAM human S177 33402212 FQEAKGDsPQEKLKT HMG_box_2 X X +MAPK1 ERK2 P28482 human Caldesmon iso4 800 Q05682-4 CALD1 human S534 448466 QSVDKVTsPTKV___ X +MAPK1 ERK2 P28482 human TCF8 25705 Q62947 Zeb1 rat T867 469215 DQNDSDCtPPKKKTR X +MAPK1 ERK2 P28482 human Myc 4609 P01106 MYC human T73 448496 kkFELLPtPPLsPsR Myc_N X 46650 +MAPK1 ERK2 P28482 human Fe65 322 O00213 APBB1 human S287 451147 WEPPGRAsPsQGSSP X X +MAPK1 ERK2 P28482 human SMAD1 4086 Q15797 SMAD1 human S206 451175 SSStYPHsPTSSDPG X 9553; 5753 +MAPK1 ERK2 P28482 human ADD1 118 P35611 ADD1 human S358 452287 AKsRsPGsPVGEGtG X X +MAPK1 ERK2 P28482 human MCR 4306 P08235 NR3C2 human S263 18503884 NVGsPLssPLSSMKS X +MAPK1 ERK2 P28482 human MCR 4306 P08235 NR3C2 human S227 25692900 FGSFPVHsPITQGTP X +MAPK1 ERK2 P28482 human SMAD2 4087 Q15796 SMAD2 human S250 448795 TGsPAELsPTTLsPV X 3104 +MAPK1 ERK2 P28482 human FAM195B 348262 C9JLW8 MCRIP1 human T30 9322247 PsSsEIFtPAHEENV FAM195 X X +MAPK1 ERK2 P28482 human p90RSK 81771 Q63531 Rps6ka1 rat S363 447989 TSRtPRDsPGIPPsA Pkinase_C X 9344 +MAPK1 ERK2 P28482 human DET1 76375 Q9D0A0 Det1 mouse S458 63280108 SAQSYSGsPYLDLSL Det1 X +MAPK1 ERK2 P28482 human GTF2I iso2 2969 P78347-2 GTF2I human S633 452350 QsPKRPRsPGSNSKV X +MAPK1 ERK2 P28482 human PPAR-gamma 19016 P37238 Pparg mouse S112 448062 AIkVEPAsPPYYSEK X +MAPK1 ERK2 P28482 human DHPS 1725 P49366 DHPS human S233 1870426002 KNHIPVFsPALTDGS DS X X +MAPK1 ERK2 P28482 human TNF-R1 21937 P25118 Tnfrsf1a mouse S299 450967 PVSStPIsPIFGPSN X +MAPK1 ERK2 P28482 human SPHK2 56848 Q9NRA0 SPHK2 human T614 477182 AFRLEPLtPRGVLTV YegS_C X X +MAPK1 ERK2 P28482 human STIM1 20866 P70302 Stim1 mouse S608 3195758 PSVPPGGsPLLDSSH X X +MAPK1 ERK2 P28482 human eNOS 287024 P29473 NOS3 cow S58 34729905 DHSPAPNsPTLTRPP X +MAPK1 ERK2 P28482 human Tau iso8 4137 P10636-8 MAPT human T153 449076 DGKtKIAtPRGAAPP X +MAPK1 ERK2 P28482 human E2A iso2 6929 P15923-2 TCF3 human S359 465682 sPStPVGsPQGLAGT X +MAPK1 ERK2 P28482 human JunD 16478 P15066 Jund mouse T117 473545 SNGLVTTtPTSTQFL Jun X +MAPK1 ERK2 P28482 human PTP-SL iso2 19279 Q62132-2 Ptprr mouse T253 450119 EPFVAVStPREKVAM X +MAPK1 ERK2 P28482 human SRC-1 8648 Q15788 NCOA1 human S395 449116 PsVNPsIsPAHGVAR X +MAPK1 ERK2 P28482 human amphiphysin 218038 Q7TQF7 Amph mouse S293 465542 PAPVRPRsPsQtRKG X +MAPK1 ERK2 P28482 human TNF-R1 21937 P25118 Tnfrsf1a mouse S273 450968 PAPsPAFsPTSGFNP X +MAPK1 ERK2 P28482 human DNMT3A 1788 Q9Y6K1 DNMT3A human S255 4700048 QQPTDPAsPTVATtP X +MAPK1 ERK2 P28482 human WAVE2 10163 Q9Y6W5 WASF2 human S296 9764438 PKRssVVsPsHPPPA X +MAPK1 ERK2 P28482 human CIITA 4261 P33076 CIITA human S288 2286408 PDRPGsTsPFAPsAT X X +MAPK1 ERK2 P28482 human OLA1 67059 Q9CZ30 Ola1 mouse Y236 1880539204 VNLsEkDyIRKKNKW X +MAPK1 ERK2 P28482 human TTK 7272 P33981 TTK human S821 467281 GQLVGLNsPNsILkA X +MAPK1 ERK2 P28482 human NUP50 10762 Q9UKX7 NUP50 human S221 476622 kVAAEtQsPsLFGst X X +MAPK1 ERK2 P28482 human Kv4.2 16508 Q9Z0V2 Kcnd2 mouse T607 457612 IPtPPVttPEGDDRP X +MAPK1 ERK2 P28482 human STAT3 6774 P40763 STAT3 human S727 448191 NtIDLPMsPrTLDSL X 9134; 9136; 34911; 94994; 49081; 58978; 87544; 71958; 50804 +MAPK1 ERK2 P28482 human GRB10 2887 Q13322 GRB10 human S476 455870 MNILGsQsPLHPSTL X X 11817 +MAPK1 ERK2 P28482 human Tau iso8 4137 P10636-8 MAPT human S191 487448 ssGEPPKsGDRsGys X +MAPK1 ERK2 P28482 human FOXO3A 2309 O43524 FOXO3 human S425 2058400 TKGsGLGsPtSSFNS X X 64616 +MAPK1 ERK2 P28482 human PLA2G4A 5321 P47712 PLA2G4A human S505 447597 LNTSYPLsPLSDFAT PLA2_B X 2831; 53044 +MAPK1 ERK2 P28482 human HSP75 10131 Q12931 TRAP1 human S511 55374803 NrHLAEHsPyyEAMk HSP90 X +MAPK1 ERK2 P28482 human myocardin 214384 Q8VIM5 Myocd mouse S812 10791200 EVLLNSHsPIGKVSD X X +MAPK1 ERK2 P28482 human RAB3IP 29885 Q62739 Rab3ip rat S250 482771 VLSSsPTsPTQEPLA Sec2p X X +MAPK1 ERK2 P28482 human PR 18667 Q00175 Pgr mouse S294 447987 SPIAPGRsPLATTVV Prog_receptor X 13736 +MAPK1 ERK2 P28482 human OLA1 67059 Q9CZ30 Ola1 mouse T325 1880539200 AWTIRKGtKAPQAAG X X +MAPK1 ERK2 P28482 human CACNA1B 100008979 Q05152 CACNA1B rabbit S411 459047 DRNAEEKsPLDAVLK X +MAPK1 ERK2 P28482 human RBPMS 19663 Q9WVB0 Rbpms mouse T118 3208560 VGtPNPstPLPNTVP X X +MAPK1 ERK2 P28482 human MBP 618684 P02687 MBP cow T97 450929 KNIVtPRtPPPSQGK Myelin_MBP X +MAPK1 ERK2 P28482 human NPAS4 225872 Q8BGD7 Npas4 mouse T423 1871095704 LSKDLVCtPPYtPHQ X +MAPK1 ERK2 P28482 human LIN28A 83557 Q8K3Y3 Lin28a mouse S200 7231811 EEEEEIHsPALLPEA X +MAPK1 ERK2 P28482 human p300 2033 Q09472 EP300 human T317 486259 VQQPGLVtPVAQGMG X +MAPK1 ERK2 P28482 human SP1 6667 P08047 SP1 human T739 448227 sEGSGtAtPSALITT X X +MAPK1 ERK2 P28482 human hnRNP E2 5094 Q15366 PCBP2 human T213 482919 SASFPHTtPSMCLNP X X +MAPK1 ERK2 P28482 human ERK2 116590 P63086 Mapk1 rat T188 3949250 FLtEyVAtRWYRAPE Pkinase X +MAPK1 ERK2 P28482 human KHDRBS1 20218 Q60749 Khdrbs1 mouse T71 449877 PPLLPPStPGPDAtV X +MAPK1 ERK2 P28482 human dematin 2039 Q08495 DMTN human S96 1983773 KstsPPPsPEVWADs AbLIM_anchor X X +MAPK1 ERK2 P28482 human NCOA6 23054 Q14686 NCOA6 human S884 470103 NKDVTLTsPLLVNLL X +MAPK1 ERK2 P28482 human CK2A1 1457 P68400 CSNK2A1 human T360 449985 SGISSVPtPsPLGPL X X +MAPK1 ERK2 P28482 human TR-beta1 7068 P10828 THRB human S142 449635 IQKNLHPsYSCkYEG zf-C4 X X +MAPK1 ERK2 P28482 human STIM1 20866 P70302 Stim1 mouse S621 3635048 SHSLSPSsPDPDTPs X X +MAPK1 ERK2 P28482 human TH 25085 P04177 Th rat S8 448543 MPTPSAPsPQPKGFR TOH_N X +MAPK1 ERK2 P28482 human CITED2 10370 Q99967 CITED2 human T166 27145810 KHSGGSStPGGSGGS CITED X +MAPK1 ERK2 P28482 human MITF 4286 O75030 MITF human S180 450264 PGSSAPNsPMAMLTL MITF_TFEB_C_3_N X +MAPK1 ERK2 P28482 human CACNB1 50688 P54283 Cacnb1 rat S161 459045 CEVGFIPsPVKLDSL X +MAPK1 ERK2 P28482 human Ets-1 2113 P14921 ETS1 human T38 447950 CADVPLLtPSSkEMM X +MAPK1 ERK2 P28482 human PAP-alpha 18789 Q61183 Papola mouse S537 1737605 DNSMSVPsPTSAMKT X X +MAPK1 ERK2 P28482 human TH iso3 7054 P07101-3 TH human S31 448544 KQAEAIMsPRFIGRR TOH_N X +MAPK1 ERK2 P28482 human STIM1 6786 Q13586 STIM1 human S621 3635048 SRsHsPssPDPDtPs X +MAPK1 ERK2 P28482 human NPAS4 225872 Q8BGD7 Npas4 mouse S615 1871095701 GLLtPEAsPVKQSFF X +MAPK1 ERK2 P28482 human SMAD2 4087 Q15796 SMAD2 human S245 448794 NQsMDTGsPAELsPT X 3104 +MAPK1 ERK2 P28482 human NUP153 9972 P49790 NUP153 human T369 3191104 PPVQRLMtPKPVsIA Nup153 X +MAPK1 ERK2 P28482 human PRDX6 94167 O35244 Prdx6 rat T177 3823356 TASNPVAtPVDWKKG 1-cysPrx_C X +MAPK1 ERK2 P28482 human Bcl-6 604 P41182 BCL6 human S333 447600 KGLVsPQsPQKsDCQ X +MAPK1 ERK2 P28482 human SOS1 6654 Q07889 SOS1 human S1178 451315 IMSKHLDsPPAIPPR X +MAPK1 ERK2 P28482 human ER-beta 13983 O08537 Esr2 mouse S105 447914 LYAEPQKsPWCEARS ERbeta_N X +MAPK1 ERK2 P28482 human Abi-1 10006 Q8IZP0 ABI1 human S183 486178 PPtQKPPsPPMsGRG X X +MAPK1 ERK2 P28482 human SYN1 24949 P09951 Syn1 rat S67 451573 VAsPAAPsPGSSGGG X +MAPK1 ERK2 P28482 human ELK1 13712 P41969 Elk1 mouse S384 447872 IHFWSTLsPIAPRsP X 9181; 9186 +MAPK1 ERK2 P28482 human p21Cip1 1026 P38936 CDKN1A human S98 478193 GGRRPGTsPALLQGT X +MAPK1 ERK2 P28482 human CTNND1 1500 O60716 CTNND1 human T310 450457 GtARRtGtPsDPRRR X +MAPK1 ERK2 P28482 human ERK5 5598 Q13164 MAPK7 human T733 455520 LPPVFsGtPKGSGAG X +MAPK1 ERK2 P28482 human Abi-1 10006 Q8IZP0 ABI1 human S225 1983922 ARLGsQHsPGRtAsL X X +MAPK1 ERK2 P28482 human Kv4.2 16508 Q9Z0V2 Kcnd2 mouse S616 457613 EGDDRPEsPEYsGGN X +MAPK1 ERK2 P28482 human DUSP5 1847 Q16690 DUSP5 human T321 10206802 ESEILPStPNPQPPS X +MAPK1 ERK2 P28482 human p300 2033 Q09472 EP300 human S2366 486264 MEQGHFAsPDQNSML X X +MAPK1 ERK2 P28482 human Kir6.2 16514 Q61743 Kcnj11 mouse T341 2103600 GNTIKVPtPLCTARQ IRK_C X +MAPK1 ERK2 P28482 human YTHDF2 51441 Q9Y5A9 YTHDF2 human S39 483929 DDFEPyLsPQARPNN X +MAPK1 ERK2 P28482 human Kv4.2 16508 Q9Z0V2 Kcnd2 mouse T602 457611 TAIISIPtPPVttPE X +MAPK1 ERK2 P28482 human TNF-R1 21937 P25118 Tnfrsf1a mouse T296 25573803 FSsPVSStPIsPIFG X +MAPK1 ERK2 P28482 human SMAD1 4086 Q15797 SMAD1 human S214 451176 PTSSDPGsPFQMPAD X +MAPK1 ERK2 P28482 human SMAD3 4088 P84022 SMAD3 human T179 451177 PQSNIPEtPPPGYLS X +MAPK1 ERK2 P28482 human NEUROD1 18012 Q60867 Neurod1 mouse S259 465678 ALEPFFEsPLTDCTs Neuro_bHLH X +MAPK1 ERK2 P28482 human NEUROD1 18012 Q60867 Neurod1 mouse S274 465680 PSFDGPLsPPLSING Neuro_bHLH X +MAPK1 ERK2 P28482 human SMAD3 4088 P84022 SMAD3 human S213 451180 NLsPNPMsPAHNNLD X +MAPK1 ERK2 P28482 human p300 2033 Q09472 EP300 human T938 486260 LLPPQPAtPLSQPAV X +MAPK1 ERK2 P28482 human SHC4 399694 Q6S5L8 SHC4 human T159 1868546600 GHRATALtPDSCPLP X X +MAPK1 ERK2 P28482 human PML iso4 5371 P29590-4 PML human S530 451473 DGPPsPRsPVIGsEV DUF3583 X X +MAPK1 ERK2 P28482 human SREBP-2 6721 Q12772 SREBF2 human S432 451007 NQNVLLMsPPASDSG X X +MAPK1 ERK2 P28482 human CENPE 1062 Q02224 CENPE human S2608 459189 tCENsPKsPKVtGTA X +MAPK1 ERK2 P28482 human GLE1 2733 Q53GS7 GLE1 human T102 472369 FsPAsPAtPNGTKGk X +MAPK1 ERK2 P28482 human SRC-2 10499 Q15596 NCOA2 human S736 465446 tIkQEPVsPkkKENA DUF4927 X +MAPK1 ERK2 P28482 human TNF-R1 21937 P25118 Tnfrsf1a mouse T286 25573801 NPTLGFStPGFSsPV X +MAPK1 ERK2 P28482 human NEUROD1 18012 Q60867 Neurod1 mouse S266 465679 sPLTDCTsPSFDGPL Neuro_bHLH X +MAPK1 ERK2 P28482 human SREBP-1 6720 P36956 SREBF1 human S117 469986 YPSMPAFsPGPGIkE X X +MAPK1 ERK2 P28482 human FOXO3A 2309 O43524 FOXO3 human S12 9318037 PAsPAPLsPLEVELD X +MAPK1 ERK2 P28482 human GLRA1 14654 Q64018 Glra1 mouse S408 1869137000 PPPAPSKsPEEMRkL X X +MAPK1 ERK2 P28482 human GAB1 2549 Q13480 GAB1 human T476 451274 EANyVPMtPGTFDFS X +MAPK1 ERK2 P28482 human Abi-1 10006 Q8IZP0 ABI1 human S267 18715503 PIAVPtPsPPTIGPE X +MAPK1 ERK2 P28482 human myocardin 214384 Q8VIM5 Myocd mouse S859 10791202 ELLPGPLsPMHAQLs X X +MAPK1 ERK2 P28482 human KSR 16706 Q61097 Ksr1 mouse S443 449300 TTSSTPSsPAPFLTS X +MAPK1 ERK2 P28482 human N-Myc 4613 P04198 MYCN human S62 448222 LLPtPPLsPsrGFAE Myc_N X +MAPK1 ERK2 P28482 human PARP1 142 P09874 PARP1 human T373 463805 AAtPPPstAsAPAAV X +MAPK1 ERK2 P28482 human AML1 iso8 861 Q01196-8 RUNX1 human S303 454401 VHPAtPIsPGRASGM X +MAPK1 ERK2 P28482 human NHE1 6548 P19634 SLC9A1 human S693 468293 VPAHKLDsPtMsRAR NEXCaM_BD X +MAPK1 ERK2 P28482 human NHE1 6548 P19634 SLC9A1 human S770 475073 MMRsKETssPGtDDV X +MAPK1 ERK2 P28482 human Bcl-2 596 P10415 BCL2 human S87 448396 AAAGPALsPVPPVVH X X +MAPK1 ERK2 P28482 human p27Kip1 1027 P46527 CDKN1B human T187 447875 NAGsVEQtPKKPGLR X +MAPK1 ERK2 P28482 human RBM17 84991 Q96I25 RBM17 human T71 470694 DDrQIVDtPPHVAAG X X +MAPK1 ERK2 P28482 human Tau iso8 4137 P10636-8 MAPT human S46 447926 tDAGLkEsPLQtPtE X 20296 +MAPK1 ERK2 P28482 human NFAT3 4776 Q14934 NFATC4 human S676 455348 SNGRRKRsPTQSFRF RHD_dimer X X +MAPK1 ERK2 P28482 human MCR 4306 P08235 NR3C2 human S361 25692903 TLRDVVPsPDTQEKG X +MAPK1 ERK2 P28482 human MBP 4155 P02686 MBP human T232 450929 KNIVTPRtPPPSQGK Myelin_MBP X +MAPK1 ERK2 P28482 human JMJD2B 23030 O94953 KDM4B human S566 452590 PTWkEPVsPMELTGP X +MAPK1 ERK2 P28482 human p70S6K 83840 P67999 Rps6kb1 rat S441 450015 sPRRFIGsPRtPVsP X +MAPK1 ERK2 P28482 human NHE1 6548 P19634 SLC9A1 human T779 3914103 PGtDDVFtPAPsDsP X +MAPK1 ERK2 P28482 human TOP2A 7153 P11388 TOP2A human S1361 455094 sPPKTKtsPKLsNkE X +MAPK1 ERK2 P28482 human PITPNM1 9600 O00562 PITPNM1 human T794 451456 LEMLVPStPTSTSGA DDHD X +MAPK1 ERK2 P28482 human HER2 2064 P04626 ERBB2 human T701 472481 TELVEPLtPsGAMPN X +MAPK1 ERK2 P28482 human SREBP-1 iso3 6720 P36956-3 SREBF1 human T81 36533415 SPPQPAPtPLKMYPS X +MAPK1 ERK2 P28482 human smMLCK 100009143 P29294 MYLK rabbit S1005 455821 GLSGRKSsTGSPTsP X +MAPK1 ERK2 P28482 human 4E-BP1 1978 Q13541 EIF4EBP1 human S65 447527 FLMECrNsPVtktPP eIF_4EBP X 9451; 9456; 13443 +MAPK1 ERK2 P28482 human C/EBP-alpha 1050 P49715 CEBPA human S21 448308 PMsSHLQsPPHAPSS X X 2841 +MAPK1 ERK2 P28482 human NOX5 iso4 79400 Q96PH1-4 NOX5 human S498 472626 RSVtMRKsQRSsKGS FAD_binding_8 X +MAPK1 ERK2 P28482 human ERF 2077 P50548 ERF human T526 448321 GEAGGPLtPRRVssD X X +MAPK1 ERK2 P28482 human DUSP6 67603 Q9DBB1 Dusp6 mouse S159 455265 DGSCSSSsPPLPVLG X +MAPK1 ERK2 P28482 human NUP153 9972 P49790 NUP153 human S516 3191083 TNKVQMtsPsstGsP Nup153 X +MAPK1 ERK2 P28482 human RAB3IP 29885 Q62739 Rab3ip rat S247 2023489 KTLVLSSsPTsPTQE Sec2p X X +MAPK1 ERK2 P28482 human RSK2 110651 P18654 Rps6ka3 mouse S227 448063 DHEKKAysFCGtVEy Pkinase X 3556 +MAPK1 ERK2 P28482 human RBPMS 19663 Q9WVB0 Rbpms mouse T12 6054914 GKAEkENtPsEANLQ X +MAPK1 ERK2 P28482 human Tau iso8 4137 P10636-8 MAPT human S202 447928 sGyssPGsPGtPGsR X 39357; 30505 +MAPK1 ERK2 P28482 human DUSP5 1847 Q16690 DUSP5 human S376 10206801 TVSELSRsPVATATS X +MAPK1 ERK2 P28482 human Snail1 6615 O95863 SNAI1 human S104 455881 GkGsQPPsPPsPAPs X X +MAPK1 ERK2 P28482 human NUP153 9972 P49790 NUP153 human S257 3191077 ktsQLGDsPFyPGkT Nup153 X +MAPK1 ERK2 P28482 human PKM 5315 P14618 PKM human S37 476070 MCRLDIDsPPItARN X X +MAPK1 ERK2 P28482 human METTL3 56339 Q86U44 METTL3 human S43 483736 rNPEAALsPTFRsDs X +MAPK1 ERK2 P28482 human PXN iso2 5829 P49023-2 PXN human S130 450228 KQKsAEPsPtVMSts Paxillin X +MAPK1 ERK2 P28482 human p300 2033 Q09472 EP300 human S2315 486263 RsPQPVPsPrPQsQP X X +MAPK1 ERK2 P28482 human RIMS1 84556 Q9JIR4 Rims1 rat S447 2761601 ARVsPPEsPRARAAA X +MAPK1 ERK2 P28482 human CITED2 17684 O35740 Cited2 mouse T166 27145810 KHSGGSStPGGAGGS CITED X +MAPK1 ERK2 P28482 human HIF2A 2034 Q99814 EPAS1 human S672 56668652 APLGPPVsPPHVSTF X X +MAPK1 ERK2 P28482 human STIM1 20866 P70302 Stim1 mouse S575 468876 LVEKLPDsPALAKKT X X +MAPK1 ERK2 P28482 human p21Cip1 1026 P38936 CDKN1A human S130 455618 sGEQAEGsPGGPGDs X X +MAPK1 ERK2 P28482 human CDC73 79577 Q6P1J9 CDC73 human S465 1879768900 PWLLPDGsPVDIFAK X +MAPK1 ERK2 P28482 human FRA2 2355 P15408 FOSL2 human S320 4707550 QSSDsLNsPtLLAL_ X +MAPK1 ERK2 P28482 human BAD 572 Q92934 BAD human S75 447860 EIRsRHssyPAGtED Bcl-2_BAD X 9291; 5284; 9296; 5193; 11865; 94223 +MAPK1 ERK2 P28482 human NDEL1 81565 Q9GZM8 NDEL1 human T245 3211851 GFGtsPLtPSARISA NUDE_C X +MAPK1 ERK2 P28482 human CITED2 10370 Q99967 CITED2 human S85 27145811 VNGGHPPsALAPAAR CITED X +MAPK1 ERK2 P28482 human RXRA 6256 P19793 RXRA human S260 450891 NMGLNPssPNDPVtN Hormone_recep X X +MAPK1 ERK2 P28482 human NUP153 9972 P49790 NUP153 human S338 468337 IVssPLNsPLDrsGI Nup153 X +MAPK1 ERK2 P28482 human Snail2 6591 O43623 SNAI2 human S87 25525400 SSSLGRVsPPPPsDT X X +MAPK1 ERK2 P28482 human BIK 12124 O70337 Bik mouse T116 25171001 IWSWRVLtPGAWVSP bcl-2I13 X +MAPK1 ERK2 P28482 human SRm300 75956 Q8BTI8 Srrm2 mouse S1068 453278 GsLsRsssPVtELtA X X +MAPK1 ERK2 P28482 human eIF4G iso8 1981 Q04637-8 EIF4G1 human S1232 449798 EAALPPVsPLKAALs X X +MAPK1 ERK2 P28482 human RAB3IP 29885 Q62739 Rab3ip rat S19 37039803 VNLAsPTsPDLLGVC X X +MAPK1 ERK2 P28482 human CENPE 1062 Q02224 CENPE human S2639 459190 QDPVPKEsPkSCFFD X +MAPK1 ERK2 P28482 human KLF4 16600 Q60793 Klf4 mouse S132 24976100 ASASSSSsPASSGPA X +MAPK1 ERK2 P28482 human PLCB1 23236 Q9NQ66 PLCB1 human S982 4787475 KkKsEPssPDHGssT X X +MAPK1 ERK2 P28482 human TRF2 7014 Q15554 TERF2 human S365 452842 PTQALPAsPALKNKR X X +MAPK1 ERK2 P28482 human NHE1 6548 P19634 SLC9A1 human S771 475074 MRsKETssPGtDDVF X +MAPK1 ERK2 P28482 human CAPN2 824 P17655 CAPN2 human S50 451162 GTLFQDPsFPAIPSA Peptidase_C2 X +MAPK1 ERK2 P28482 human NHE1 6548 P19634 SLC9A1 human S723 2509103 VItIDPAsPQsPEsV X +MAPK1 ERK2 P28482 human PRDX6 9588 P30041 PRDX6 human T177 3823356 TAEKRVAtPVDWkDG 1-cysPrx_C X +MAPK1 ERK2 P28482 human ER-alpha 2099 P03372 ESR1 human S118 448101 LHPPPQLsPFLQPHG Oest_recep X X 2511 +MAPK1 ERK2 P28482 human 4E-BP1 116636 Q62622 Eif4ebp1 rat T45 447496 GGtLFSttPGGtRII eIF_4EBP X 2855; 9459; 2846; 5123; 3929; 7547; 45613; 39788 +MAPK1 ERK2 P28482 human MKL1 57591 Q969V6 MRTFA human S454 467355 tGstPPVsPtPsERS X +MAPK1 ERK2 P28482 human SOS1 6654 Q07889 SOS1 human S1197 451317 kAYsPrysISDRTSI X +MAPK1 ERK2 P28482 human DAZAP1 26528 Q96EP5 DAZAP1 human T315 467205 GVPPPPAtPGAAPLA X +MAPK1 ERK2 P28482 human GRB10 2887 Q13322 GRB10 human S150 454185 PELCGPGsPPVLtPG X X +MAPK1 ERK2 P28482 human supervillin Q6U1J6 SVIL ferret S132 7721700 DSEADSEsPSRYTKS X X +MAPK1 ERK2 P28482 human NIPA 232679 Q80YV2 Zc3hc1 mouse S358 483339 tRsWEsssPVDRPEL X +MAPK1 ERK2 P28482 human NHE1 6548 P19634 SLC9A1 human S785 1983418 FtPAPsDsPssQRIQ X +MAPK1 ERK2 P28482 human METTL3 56339 Q86U44 METTL3 human S525 1871246003 YGMIERLsPGTRKIE MT-A70 X +MAPK1 ERK2 P28482 human SMAD3 4088 P84022 SMAD3 human S208 451179 DAGsPNLsPNPMsPA X +MAPK1 ERK2 P28482 human RSK2 6197 P51812 RPS6KA3 human Y529 464205 TITKTVEyLHAQGVV Pkinase X +MAPK1 ERK2 P28482 human NUP153 9972 P49790 NUP153 human S320 4747698 QsLEkMssPLADAkR Nup153 X +MAPK1 ERK2 P28482 human MBP 618684 P02687 MBP cow T94 455362 HFFKNIVtPRtPPPS Myelin_MBP X +MAPK1 ERK2 P28482 human ER-alpha 2099 P03372 ESR1 human S106 448100 PLNsVsPsPLMLLHP Oest_recep X X +MAPK1 ERK2 P28482 human ADD2 119 P35612 ADD2 human S600 481589 PAksAPAsPVQsPAK X X +MAPK1 ERK2 P28482 human JMJD2B 23030 O94953 KDM4B human S352 4957088 tRPTALTsPELSSWS X +MAPK1 ERK2 P28482 human SOS1 6654 Q07889 SOS1 human S1193 451316 QPTSkAYsPrysISD X +MAPK1 ERK2 P28482 human 5-LO 240 P09917 ALOX5 human S664 461913 QLPYYYLsPDRIPNs X 3749 +MAPK1 ERK2 P28482 human JMJD2B 23030 O94953 KDM4B human T1065 479896 AKRPRVGtPLAtEDS X +MAPK1 ERK2 P28482 human E2A iso2 6929 P15923-2 TCF3 human S352 465681 SSNNFSSsPStPVGs X +MAPK1 ERK2 P28482 human capicua 23152 Q96RK0 CIC human S1409 453485 sAPEDPtsPKRKMRR X +MAPK1 ERK2 P28482 human p47phox 653361 P14598 NCF1 human S345 451727 QARPGPQsPGsPLEE X +MAPK1 ERK2 P28482 human mGluR5 108071 Q3UVX5 Grm5 mouse S1158 25581600 LVALtPPsPFRDSVD GluR_Homer-bdg X +MAPK1 ERK2 P28482 human WTAP 9589 Q15007 WTAP human T148 36131377 ELSAWkFtPDSQTGK Wtap X +MAPK1 ERK2 P28482 human PIMT 96764 Q96RS0 TGS1 human S298 3636737 DLVsFPssPIMVDND X X +MAPK1 ERK2 P28482 human p70S6K 83840 P67999 Rps6kb1 rat S434 448356 SFEPKIRsPRRFIGs X +MAPK1 ERK2 P28482 human Oct4 5460 Q01860 POU5F1 human S111 25236703 EsNsDGAsPEPCtVt X X +MAPK1 ERK2 P28482 human Cofilin-1 12631 P18760 Cfl1 mouse T25 7990494 MkVRKSstPEEVKkR Cofilin_ADF X +MAPK1 ERK2 P28482 human TTP 22695 P22893 Zfp36 mouse S220 457797 PPGDLPLsPSAFSAA X +MAPK1 ERK2 P28482 human RBPMS 19663 Q9WVB0 Rbpms mouse S144 34503161 VPALYPSsPEVWAPY X +MAPK1 ERK2 P28482 human Mnk1 8569 Q9BUB5 MKNK1 human T255 447622 ITtPELTtPCGSAEY Pkinase X 2111; 43507 +MAPK1 ERK2 P28482 human DUSP6 67603 Q9DBB1 Dusp6 mouse S197 455266 SATDSDGsPLSNSQP X +MAPK1 ERK2 P28482 human TOB1 10140 P50616 TOB1 human S152 455535 PASSVSSsPsPPFGH X X +MAPK1 ERK2 P28482 human ADD1 118 P35611 ADD1 human S669 6421811 EEAHRPPsPtEAPTE X X +MAPK1 ERK2 P28482 human Tau iso8 4137 P10636-8 MAPT human T217 449078 sRtPsLPtPPtREPK X 33134; 51625 +MAPK1 ERK2 P28482 human CDCA5 113130 Q96FF9 CDCA5 human S209 3208965 DMtLPGIsPPPEKQK Sororin X +MAPK1 ERK2 P28482 human 53BP2 7159 Q13625 TP53BP2 human S827 30995203 NSDMPAPsPGLDYEP X +MAPK1 ERK2 P28482 human NR2C1 22025 Q505F1 Nr2c1 mouse T210 4206803 sPLAAtPtFVTDSET X +MAPK1 ERK2 P28482 human MAPKAPK2 9261 P49137 MAPKAPK2 human S9 449763 LSNSQGQsPPVPFPA X +MAPK1 ERK2 P28482 human RPS3 6188 P23396 RPS3 human T42 455909 sGVEVRVtPTRtEII KH_2 X X +MAPK1 ERK2 P28482 human BIM 64547 O88498 Bcl2l11 rat S65 449330 GPLAPPAsPGPFATR X 4581; 4585 +MAPK1 ERK2 P28482 human AKAP4 8852 Q5JQC9 AKAP4 human T265 457176 KERISPRtPAsKIAs AKAP_110 X X +MAPK1 ERK2 P28482 human PXN 360820 Q66H76 Pxn rat S130 450228 KQKsAEPsPtVMSss Paxillin X X +MAPK1 ERK2 P28482 human MDM2 4193 Q00987 MDM2 human S166 448130 SsRRRAIsEtEENsD X 3521 +MAPK1 ERK2 P28482 human MSK1 73086 Q8C050 Rps6ka5 mouse T764 471413 LssNPLMtPDILGSS X +MAPK1 ERK2 P28482 human RBPMS 19663 Q9WVB0 Rbpms mouse S14 14579056 AEkENtPsEANLQEE X +MAPK1 ERK2 P28482 human TWIST1 7291 Q15672 TWIST1 human S68 18905000 GGGDEPGsPAQGkRG X X +MAPK1 ERK2 P28482 human CTNND1 1500 O60716 CTNND1 human T308 3651652 DyGtARRtGtPsDPR X +MAPK1 ERK2 P28482 human MAPKAPK2 9261 P49137 MAPKAPK2 human T222 448269 tSHNsLttPCytPYY Pkinase X 3316 +MAPK1 ERK2 P28482 human DCC 25311 Q63155 Dcc rat T1187 26395103 IQSCQDLtPVSHSQS Neogenin_C X +MAPK1 ERK2 P28482 human separase 9700 Q14674 ESPL1 human S1126 447673 IAPStNSsPVLKTKP X +MAPK1 ERK2 P28482 human Tau iso8 4137 P10636-8 MAPT human T50 447931 LkEsPLQtPtEDGsE X +MAPK1 ERK2 P28482 human AML1 iso8 861 Q01196-8 RUNX1 human S462 454402 AEGSHSNsPTNMAPS RunxI X +MAPK1 ERK2 P28482 human MED1 5469 Q15648 MED1 human T1457 449866 HsKsPAytPQNLDsE X X +MAPK1 ERK2 P28482 human ARHGEF2 9181 Q92974 ARHGEF2 human T679 449343 PGVELLLtPREPALP X +MAPK1 ERK2 P28482 human Fos 314322 P12841 Fos rat T325 448483 TELEPLCtPVVTCtP X +MAPK1 ERK2 P28482 human TPPP 11076 O94811 TPPP human S160 487536 GVtKAIssPtVSRLT p25-alpha X +MAPK1 ERK2 P28482 human MSK1 9252 O75582 RPS6KA5 human S360 448215 TEMDPTYsPAALPQS Pkinase_C X 9594 +MAPK1 ERK2 P28482 human DCP1A 75901 Q91YD3 Dcp1a mouse S339 3213297 LPLsPVLsPTLPAEA X +MAPK1 ERK2 P28482 human NPAS4 225872 Q8BGD7 Npas4 mouse T611 1871095703 LVPEGLLtPEAsPVK X +MAPK1 ERK2 P28482 human CBX7 52609 Q8VDS3 Cbx7 mouse T119 29669800 TNGPPPWtPTLPSSE CBX7_C X +MAPK1 ERK2 P28482 human PSD-93 1740 Q15700 DLG2 human S323 472024 KtsLPPIsPGRySPI PDZ_assoc X +MAPK1 ERK2 P28482 human 4E-BP1 1978 Q13541 EIF4EBP1 human T70 447528 rNsPVtktPPRDLPt eIF_4EBP X 9455; 13396 +MAPK1 ERK2 P28482 human SPHK2 56848 Q9NRA0 SPHK2 human S387 477181 PATVEPAsPTPAHSL X X +MAPK1 ERK2 P28482 human PBK 55872 Q96KB5 PBK human S32 471715 PtINIPAsPFMQKLG X X +MAPK1 ERK2 P28482 human HePTP 5778 P35236 PTPN7 human T66 448311 EPICsVNtPREVTLH X +MAPK1 ERK2 P28482 human Jun 3725 P05412 JUN human S73 447943 VGLLkLAsPELERLI Jun X X 9164; 3270; 8752; 12714; 77955 +MAPK1 ERK2 P28482 human Snail2 6591 O43623 SNAI2 human S104 25603909 KDHsGSEsPISDEEE X +MAPK1 ERK2 P28482 human SREBP-1 iso3 6720 P36956-3 SREBF1 human S93 469986 YPSMPAFsPGPGIKE X +MAPK1 ERK2 P28482 human MEK1 5604 Q02750 MAP2K1 human T286 448286 VEGdAAEtPPRPRtP Pkinase X 9127 +MAPK1 ERK2 P28482 human TXNIP 10628 Q9H3M7 TXNIP human T349 3212307 HRLEsPttPLLDDMD X X +MAPK1 ERK2 P28482 human NCAM-L1 3897 P32004 L1CAM human S1248 472277 NDssGAtsPINPAVA X +MAPK1 ERK2 P28482 human HIF1A 3091 Q16665 HIF1A human S643 470106 kILIAsPsPTHIHkE X +MAPK1 ERK2 P28482 human FBXW7 55294 Q969H0 FBXW7 human S176 25126709 KRKLDHGsEVRSFSL X +MAPK1 ERK2 P28482 human SMAD3 4088 P84022 SMAD3 human S204 451178 NHSMDAGsPNLsPNP X +MAPK1 ERK2 P28482 human RBPMS 19663 Q9WVB0 Rbpms mouse T187 1880754300 WIPPSEAtSQGWkSR X +MAPK1 ERK2 P28482 human PDE4D iso4 5144 Q08499-4 PDE4D human S490 451090 YQSTIPQsPSPAPDD X X +MAPK1 ERK2 P28482 human girdin 55704 Q3V6T2 CCDC88A human S233 4725929 HASSSAQsPCGsPGM X +MAPK1 ERK2 P28482 human CITED2 10370 Q99967 CITED2 human T175 27145812 GGSGGSStPGGSGSS CITED X +MAPK1 ERK2 P28482 human HSF4 3299 Q9ULV5 HSF4 human S298 4037600 LLkEEPAsPGGDGEA X X +MAPK1 ERK2 P28482 human DYRK1B 9149 Q9Y463 DYRK1B human S421 50269512 YEPAARIsPLGALQH Pkinase X +MAPK1 ERK2 P28482 human SOX10 6663 P56693 SOX10 human T244 628303300 GPPtPPTtPkTELQS X X +MAPK1 ERK2 P28482 human FRA2 14284 P47930 Fosl2 mouse S320 4707550 QSSDSLNsPtLLAL_ X +MAPK1 ERK2 P28482 human METTL3 56339 Q86U44 METTL3 human S50 3204585 sPTFRsDsPVPtAPt X +MAPK1 ERK2 P28482 human USP11 8237 P51784 USP11 human S948 466974 GssGAPAsPACssPP X +MAPK1 ERK2 P28482 human Abi-1 10006 Q8IZP0 ABI1 human T394 12626406 ENIADsPtPPPPPPP X +MAPK1 ERK2 P28482 human FAM195B 348262 C9JLW8 MCRIP1 human S21 486127 kRtssPRsPPsSsEI FAM195 X X +MAPK1 ERK2 P28482 human DCC 25311 Q63155 Dcc rat S1267 26395104 QyPGILPsPTCGYPH Neogenin_C X +MAPK1 ERK2 P28482 human NUP153 9972 P49790 NUP153 human S529 452707 sPMFKFSsPIVKsTE Nup153 X X +MAPK1 ERK2 P28482 human CEP55 55165 Q53EZ4 CEP55 human S425 457628 NREKVAAsPksPtAA X +MAPK1 ERK2 P28482 human Snail1 6615 O95863 SNAI1 human S82 11493501 ASLRLQEsPRVAELT X X +MAPK1 ERK2 P28482 human 4E-BP1 116636 Q62622 Eif4ebp1 rat T36 447497 PPGDYsttPGGtLFS eIF_4EBP X 2855; 9459; 2846; 5123; 3929; 7547; 45613; 39788 +MAPK1 ERK2 P28482 human GTF2I iso2 2969 P78347-2 GTF2I human S627 452349 INTKALQsPKRPRsP X +MAPK1 ERK2 P28482 human CASP8 841 Q14790 CASP8 human S387 16855100 yLEMDLSsPQTRYIP Peptidase_C14 X X +MAPK1 ERK2 P28482 human Bcl-2 12043 P10417 Bcl2 mouse S70 448395 RDMAARtsPLRPLVA X X +MAPK1 ERK2 P28482 human PTPRCAP 5790 Q14761 PTPRCAP human S163 4733815 EGDLVLGsPGPASAG PTPRCAP X +MAPK1 ERK2 P28482 human dematin 2039 Q08495 DMTN human S90 481650 ERsLSPKstsPPPsP AbLIM_anchor X X +MAPK1 ERK2 P28482 human ERK2 5594 P28482 MAPK1 human S246 6845001 HILGILGsPsQEDLN Pkinase X X +MAPK1 ERK2 P28482 human Stargazin 84347 Q71RJ2 Cacng2 rat T321 451273 NTANRRTtPV_____ X +MAPK1 ERK2 P28482 human Tau 29477 P19332 Mapt rat T516 447933 ssPGsPGtPGsRSRt X 25377; 43964; 53001; 49561; 20060; 33032; 30505; 20739; 98160 +MAPK1 ERK2 P28482 human JMJD2B 23030 O94953 KDM4B human S622 452591 LGRPPTRsPLsVVKQ X +MAPK1 ERK2 P28482 human RORA iso4 6095 P35398-4 RORA human T128 482887 PGEAEPLtPTYNISA X +MAPK1 ERK2 P28482 human Raptor 57521 Q8N122 RPTOR human S863 453732 LtQsAPAsPtNkGVH X X +MAPK1 ERK2 P28482 human STAT5A 6776 P42229 STAT5A human S780 448750 DsLDsRLsPPAGLFT X X +MAPK1 ERK2 P28482 human MCL1 17210 P97287 Mcl1 mouse T144 455375 ADGsLPStPPPPEEE X 4579 +MAPK1 ERK2 P28482 human Tau iso8 4137 P10636-8 MAPT human T181 447932 ktPPAPktPPssGEP X X 12885; 66224; 62672 +MAPK1 ERK2 P28482 human JunD 24518 P52909 Jund rat S100 456168 LGLLKLAsPELERLI Jun X 9164 +MAPK1 ERK2 P28482 human ELK1 13712 P41969 Elk1 mouse T418 452139 ISVDGLStPVVLsPG X +MAPK1 ERK2 P28482 human MCR 4306 P08235 NR3C2 human S287 4767239 SVKsPVSsPNNVTLR X +MAPK1 ERK2 P28482 human STF-1 26423 P33242 Nr5a1 mouse S203 447603 EYPEPYAsPPQQPGP X X +MAPK1 ERK2 P28482 human DRP1 10059 O00429 DNM1L human S616 454690 PIPIMPAsPQKGHAV X X 3455; 4494; 63940 +MAPK1 ERK2 P28482 human Oct4 5460 Q01860 POU5F1 human S355 25236701 VSVTtLGsPMHsN__ X +MAPK1 ERK2 P28482 human RIMS1 84556 Q9JIR4 Rims1 rat S745 2023137 ISVIsPTsPGALKDA X +MAPK1 ERK2 P28482 human DNMT3A Q4W5Z4 DNMT3A chicken S220 4700048 QQPTDPAsPNVATTP X +MAPK1 ERK2 P28482 human REST 5978 Q13127 REST human S864 453739 TEDLsPPsPPLPKEN X X +MAPK1 ERK2 P28482 human gephyrin 64845 Q03555 Gphn rat S281 483463 AsLSttPsEsPRAQA X +MAPK1 ERK2 P28482 human HECTD3 79654 Q5T447 HECTD3 human T157 150180307 ARLVPIDtPNHLQRQ X +MAPK1 ERK2 P28482 human EGFR 1956 P00533 EGFR human T693 448054 RELVEPLtPsGEAPN X X 3056; 8808 +MAPK1 ERK2 P28482 human NHE1 24782 P26431 Slc9a1 rat S775 475073 MIRsKEPssPGTDDV X +MAPK1 ERK2 P28482 human MAPKAPK5 8550 Q8IW41 MAPKAPK5 human T182 450093 IDQGDLMtPQFtPyY Pkinase X +MAPK1 ERK2 P28482 human girdin 55704 Q3V6T2 CCDC88A human S237 4725935 SAQsPCGsPGMKRTE X +MAPK1 ERK2 P28482 human MARCKS 4082 P29966 MARCKS human S46 454165 VKVNGDAsPAAAEsG MARCKS X +MAPK1 ERK2 P28482 human ATF-2 11909 P16951 Atf2 mouse T53 448225 IVADQtPtPtRFLKN X 9225; 9221; 5112; 94125; 13850; 40749; 15411; 24329; 61584; 27934; 92109; 20534; 35858 +MAPK1 ERK2 P28482 human Jun 3725 P05412 JUN human S63 447686 kNsDLLtsPDVGLLk Jun X X 5464; 9261; 2361; 97721; 91952 +MAPK1 ERK2 P28482 human NHE1 24782 P26431 Slc9a1 rat S776 475074 IRsKEPssPGTDDVF X +MAPK1 ERK2 P28482 human PML iso4 5371 P29590-4 PML human S38 451470 EGRQPsPsPsPTERA X X +MAPK1 ERK2 P28482 human CDK2 1017 P24941 CDK2 human T160 447739 GVPVRtytHEVVtLW Pkinase X 2561 +MAPK1 ERK2 P28482 human FOXO3A 2309 O43524 FOXO3 human S344 2058401 QDDDAPLsPMLYSSS X X +MAPK1 ERK2 P28482 human TNF-R1 21937 P25118 Tnfrsf1a mouse S269 451128 KPLtPAPsPAFsPTS X +MAPK1 ERK2 P28482 human PTP-PEST 5782 Q05209 PTPN12 human S571 1983755 KtVsLtPsPtTQVEt X X +MAPK1 ERK2 P28482 human SHOC2 8036 Q9UQ13 SHOC2 human T507 1867945200 GLGENLLtHLPEEIG LRR_8 X +MAPK1 ERK2 P28482 human Abi-1 10006 Q8IZP0 ABI1 human S392 12626405 VQENIADsPtPPPPP X +MAPK1 ERK2 P28482 human TNF-R1 21937 P25118 Tnfrsf1a mouse T265 450966 EKAGKPLtPAPsPAF X +MAPK1 ERK2 P28482 human GLRA1 2741 P23415 GLRA1 human S408 1869137000 PPPAPSKsPEEMRKL X X +MAPK1 ERK2 P28482 human MCL1 4170 Q07820 MCL1 human T163 455375 tDGsLPstPPPAEEE X X 4579; 14765 +MAPK1 ERK2 P28482 human smMLCK 396445 P11799 MYLK chicken S1768 468782 AsGssPTsPINADKV X +MAPK1 ERK2 P28482 human IRS1 3667 P35568 IRS1 human S639 447507 yMPMsPKsVSAPQQI X 2388 +MAPK1 ERK2 P28482 human myocardin 214384 Q8VIM5 Myocd mouse T893 10791203 TMEWLDLtPPSSTPG X X +MAPK1 ERK2 P28482 human 4E-BP1 1978 Q13541 EIF4EBP1 human T37 447497 PPGDysttPGGtLFs eIF_4EBP X 2855; 9459; 2846; 5123; 3929; 7547; 45613; 39788 +MAPK1 ERK2 P28482 human Tau iso8 4137 P10636-8 MAPT human T175 449077 AtRIPAktPPAPktP X +MAPK1 ERK2 P28482 human RAMAC 83640 Q9BTL3 RAMAC human S36 3210933 yLKRPPEsPPIVEEW RAM X X +MAPK1 ERK2 P28482 human Abi-1 10006 Q8IZP0 ABI1 human S216 3205884 VPNDyMtsPARLGsQ X +MAPK1 ERK2 P28482 human Abi-1 10006 Q8IZP0 ABI1 human T265 18715504 GIPIAVPtPsPPTIG X +MAPK1 ERK2 P28482 human CACNA1B 100008979 Q05152 CACNA1B rabbit S447 459048 TGLCAPGsPFARASL X +MAPK1 ERK2 P28482 human MCR 4306 P08235 NR3C2 human S238 25692902 QGTPLTCsPNVENRG X +MAPK1 ERK2 P28482 human Ets-1 23871 P27577 Ets1 mouse T38 447950 CADVPLLtPSsKEMM X +MAPK1 ERK2 P28482 human DAZAP1 26528 Q96EP5 DAZAP1 human T269 467204 FTSYIVStPPGGFPP X +MAPK1 ERK2 P28482 human BMF 90427 Q96LC9 BMF human S74 11267001 DKATQTLsPAsPSQG BMF X X +MAPK1 ERK2 P28482 human p70S6K 6198 P23443 RPS6KB1 human T444 448358 RFIGsPRtPVsPVkF X 9204 +MAPK1 ERK2 P28482 human TOP2A 7153 P11388 TOP2A human S1354 452240 DFVPsDAsPPKTKts X +MAPK1 ERK2 P28482 human RBPMS 19663 Q9WVB0 Rbpms mouse S117 5815926 LVGtPNPstPLPNTV X +MAPK1 ERK2 P28482 human p70S6K 6198 P23443 RPS6KB1 human S434 448356 sFEPKIRsPRRFIGs X +MAPK1 ERK2 P28482 human ADD1 118 P35611 ADD1 human S707 13310034 GAAADPGsDGsPGKs X X +MAPK1 ERK2 P28482 human Myc 4609 P01106 MYC human S77 448586 LLPtPPLsPsRRsGL Myc_N X X 13748 +MAPK1 ERK2 P28482 human CEP55 55165 Q53EZ4 CEP55 human S428 457629 KVAAsPksPtAALNE X +MAPK1 ERK2 P28482 human IL2RB 3560 P14784 IL2RB human T476 41591300 PQPLGPPtPGVPDLV X +MAPK1 ERK2 P28482 human p90RSK 81771 Q63531 Rps6ka1 rat T573 447993 AENGLLMtPCYTANF Pkinase X 9346 +MAPK1 ERK2 P28482 human hnRNP E2 5094 Q15366 PCBP2 human S173 482916 MLETLSQsPPKGVtI X X +MAPK1 ERK2 P28482 human ELK1 13712 P41969 Elk1 mouse T364 22725902 LLPTHTLtPVLLtPS X +MAPK1 ERK2 P28482 human STMN1 16765 P54227 Stmn1 mouse S25 448555 QAFELILsPRskEsV Stathmin X +MAPK1 ERK2 P28482 human C/EBP-beta 12608 P28033 Cebpb mouse T188 447878 sSssPPGtPSPADAK X 3084 +MAPK1 ERK2 P28482 human PGK1 5230 P00558 PGK1 human S203 468410 yFAkALEsPERPFLA PGK X +MAPK1 ERK2 P28482 human GRASP55 26003 Q9H8Y8 GORASP2 human T225 470123 QMAGtPItPLKDGFT X +MAPK1 ERK2 P28482 human MED1 5469 Q15648 MED1 human T1032 458308 SSSNRPFtPPTsTGG X +MAPK1 ERK2 P28482 human ARRB2 409 P32121 ARRB2 human T276 50247604 FCKVYTItPLLSDNR Arrestin_C X +MAPK1 ERK2 P28482 human p27Kip1 1027 P46527 CDKN1B human S10 447874 NVRVSNGsPsLErMD X +MAPK1 ERK2 P28482 human Securin 30939 Q9CQJ7 Pttg1 mouse S162 452603 LLHLGPPsPLKTPFL Securin X X +MAPK1 ERK2 P28482 human DCC 25311 Q63155 Dcc rat S1178 4711110 TDPAGRGsPIQSCQD Neogenin_C X +MAPK1 ERK2 P28482 human ARHGAP26 396113 Q5ZMW5 ARHGAP26 chicken S686 452134 PMFSAPSsPMPTSST X X +MAPK1 ERK2 P28482 human PDX1 3651 P52945 PDX1 human S61 458401 LGALEQGsPPDIsPY X +MAPK1 ERK2 P28482 human GATA4 54254 P46152 Gata4 rat S105 449604 AYTPPPVsPRFSFPG GATA-N X +MAPK1 ERK2 P28482 human PARVA 55742 Q9NVD7 PARVA human S8 4270099 MAtsPQKsPsVPKsP X +MAPK1 ERK2 P28482 human Tau iso8 4137 P10636-8 MAPT human T212 447934 tPGsRsRtPsLPtPP X +MAPK1 ERK2 P28482 human IP3R1 16438 P11881 Itpr1 mouse S1765 469627 sFGNGPLsPGGPSkP X +MAPK1 ERK2 P28482 human MAFA 389692 Q8NHW3 MAFA human S65 5403102 PCSsVPSsPSFCAPS X X +MAPK1 ERK2 P28482 human PML iso4 5371 P29590-4 PML human S36 451469 PSEGRQPsPsPsPTE X X +MAPK1 ERK2 P28482 human ERG 2078 P11308 ERG human S96 4712353 kGGkMVGsPDTVGMN X X +MAPK1 ERK2 P28482 human p27Kip1 1027 P46527 CDKN1B human S178 450208 EENVsDGsPNAGsVE X +MAPK1 ERK2 P28482 human ERF 2077 P50548 ERF human S161 456969 sPtEDPRsPPACssS X X +MAPK1 ERK2 P28482 human CCNB1 891 P14635 CCNB1 human S128 448815 LVDTAsPsPMETsGC X +MAPK1 ERK2 P28482 human MAPKAPK2 9261 P49137 MAPKAPK2 human T25 448271 APPPQPPtPALPHPP X +MAPK1 ERK2 P28482 human GLI1 2735 P08151 GLI1 human S130 1877717204 HLSIGTMsPSLGFPA X +MAPK1 ERK2 P28482 human EEF2K 25435 P70531 Eef2k rat S358 447826 GTEEKCGsPRIRTLs X +MAPK1 ERK2 P28482 human Raptor 57521 Q8N122 RPTOR human S8 17538200 MESEMLQsPLLGLGE X X +MAPK1 ERK2 P28482 human Nur77 3164 P22736 NR4A1 human S431 21697917 IPGFAELsPADQDLL Hormone_recep X +MAPK1 ERK2 P28482 human CAD 790 P27708 CAD human T456 451248 KVYFLPItPHYVTQV X X +MAPK1 ERK2 P28482 human SP1 6667 P08047 SP1 human T453 448226 SGPIIIRtPTVGPNG X X +MAPK1 ERK2 P28482 human ERF 2077 P50548 ERF human S251 456968 PLsPFPVsPLAGPGS X X +MAPK1 ERK2 P28482 human HSF1 3297 Q00613 HSF1 human S326 455484 ssVDtLLsPTALIDs Vert_HS_TF X +MAPK1 ERK2 P28482 human FBXW7 55294 Q969H0 FBXW7 human T205 25585000 GLVPCSAtPTTFGDL X +MAPK1 ERK2 P28482 human TAB1 10454 Q15750 TAB1 human S438 456224 tPTLTNQsPTLtLQS X +MAPK1 ERK2 P28482 human NUP153 9972 P49790 NUP153 human S334 468336 RIPsIVssPLNsPLD Nup153 X +MAPK1 ERK2 P28482 human SOS1 6654 Q07889 SOS1 human S1132 451313 TLPHGPRsAsVssIS X +MAPK1 ERK2 P28482 human HDAC6 10013 Q9UBN7 HDAC6 human T1031 29604202 ASStDHQtPPtsPVQ X +MAPK1 ERK2 P28482 human MAPKAPK2 9261 P49137 MAPKAPK2 human T334 448273 QstKVPQtPLHtsRV X 3007; 3041 +MAPK1 ERK2 P28482 human BRAF 396239 Q04982 BRAF chicken T793 460657 YACAsPKtPIQAGGY X X +MAPK1 ERK2 P28482 human NUP214 8021 P35658 NUP214 human S1710 10296402 VSSSGFSsPAFGTTA X +MAPK1 ERK2 P28482 human Cortactin 2017 Q14247 CTTN human S418 447701 tEErLPssPVyEDAA X X +MAPK1 ERK2 P28482 human MSK1 9252 O75582 RPS6KA5 human T581 448217 PDNQPLKtPCFTLHY Pkinase X 9595 +MAPK1 ERK2 P28482 human NOXA1 10811 Q86UR1 NOXA1 human S282 12570900 VGKQAPLsPGLPAMG X X +MAPK1 ERK2 P28482 human BANP 54971 Q8N9N5 BANP human T352 41301701 PSEPMMStPPPASEL X +MAPK1 ERK2 P28482 human Bcl-2 596 P10415 BCL2 human T56 448655 FSSQPGHtPHPAASR X 2875 +MAPK1 ERK2 P28482 human NUP153 9972 P49790 NUP153 human T413 10296400 TGYEkNMtPGQNREQ Nup153 X +MAPK1 ERK2 P28482 human hnRNP E2 5094 Q15366 PCBP2 human S189 482917 yRPkPsssPVIFAGG X X +MAPK1 ERK2 P28482 human p70S6K 83840 P67999 Rps6kb1 rat T444 448358 RFIGsPRtPVsPVKF X 9204 +MAPK1 ERK2 P28482 human Kv4.2 Q63881 Kcnd2 rat T607 457612 IPtPPVTtPEGDDRP X +MAPK1 ERK2 P28482 human KIBRA 23286 Q8IX03 WWC1 human S542 25673102 sPRSsLSsPSPPCsP X +MAPK1 ERK2 P28482 human ELK1 2002 P19419 ELK1 human S383 447872 IHFWSTLsPIAPRsP X X 9181; 9186 +MAPK1 ERK2 P28482 human RAB3IP 29885 Q62739 Rab3ip rat S16 37039802 FHEVNLAsPTsPDLL X X +MAPK1 ERK2 P28482 human GATA6 2627 Q92908 GATA6 human S266 2833503 VSARFPYsPsPPMAN GATA-N X +MAPK1 ERK2 P28482 human TH 25085 P04177 Th rat S31 448544 KQAEAVtsPRFIGRR TOH_N X 3370; 13041 +MAPK1 ERK2 P28482 human p53 7157 P04637 TP53 human S15 447490 PsVEPPLsQEtFsDL P53_TAD X X 4030; 9235; 9284; 9286; 8695; 8514; 82530; 56979 +MAPK1 ERK2 P28482 human KLC1 16593 O88447 Klc1 mouse S459 477826 YKACKVDsPtVtttL X X +MAPK1 ERK2 P28482 human COPS6 10980 Q7L5N1 COPS6 human S148 48903200 QVCEIIEsPLFLkLN JAB X +MAPK1 ERK2 P28482 human GLE1 2733 Q53GS7 GLE1 human S93 31084897 PKsPDAssAFsPAsP X +MAPK1 ERK2 P28482 human TOB1 10140 P50616 TOB1 human S164 455537 FGHSAAVsPTFMPRS X X +MAPK1 ERK2 P28482 human PML iso4 5371 P29590-4 PML human S40 451471 RQPsPsPsPTERAPA X X +MAPK1 ERK2 P28482 human GLI1 2735 P08151 GLI1 human S102 41595602 LQTVIRTsPSSLVAF X +MAPK1 ERK2 P28482 human ADD2 119 P35612 ADD2 human S596 3147633 EPGsPAksAPAsPVQ X X +MAPK1 ERK2 P28482 human GAB2 9846 Q9UQC2 GAB2 human S623 454021 ALDFQPssPsPHRKP X +MAPK1 ERK2 P28482 human 4E-BP1 1978 Q13541 EIF4EBP1 human T46 447496 GGtLFsttPGGtRII eIF_4EBP X 2855; 9459; 2846; 4923; 5123; 3929; 7547; 45613; 39788 +MAPK1 ERK2 P28482 human GRASP65 56082 O35254 Gorasp1 rat S277 455582 EQLPGPGsPGHGTAD X X +MAPK1 ERK2 P28482 human RSK2 6197 P51812 RPS6KA3 human Y488 464203 DVyDDGKyVYVVTEL Pkinase X +MAPK1 ERK2 P28482 human SH2-B-beta 25970 Q9NRF2 SH2B1 human S96 457414 PPILAPLsPGAEIsP X +MAPK1 ERK2 P28482 human HIF1A 3091 Q16665 HIF1A human S641 470105 DIkILIAsPsPTHIH X +MAPK1 ERK2 P28482 human DAPK1 1612 P53355 DAPK1 human S734 454887 NsSRFPPsPLASKPT X X +MAPK1 ERK2 P28482 human myocardin 214384 Q8VIM5 Myocd mouse S866 10791201 sPMHAQLsPPSVDSS X X +MAPK1 ERK2 P28482 human RSK2 110651 P18654 Rps6ka3 mouse S386 448065 HQLFRGFsFVAITSD Pkinase_C X 9341; 9335; 13575; 11989; 12032; 75266; 93317; 13397; 13588 +MAPK1 ERK2 P28482 human CENPE 1062 Q02224 CENPE human S2605 459188 KQVtCENsPKsPKVt X +MAPK1 ERK2 P28482 human AML1 iso8 861 Q01196-8 RUNX1 human S293 454400 QYLGSIAsPSVHPAt X +MAPK1 ERK2 P28482 human 4E-BP1 116636 Q62622 Eif4ebp1 rat S82 447525 PTIPGVTsPTSDEPP eIF_4EBP X +MAPK1 ERK2 P28482 human PDE4B iso2 5142 Q07343-2 PDE4B human S487 471380 YQSMIPQsPSPPLDE X +MAPK1 ERK2 P28482 human GLE1 2733 Q53GS7 GLE1 human S92 50831365 VPKsPDAssAFsPAs X +MAPK1 ERK2 P28482 human Tau iso8 4137 P10636-8 MAPT human T205 447933 ssPGsPGtPGsRsRt X 25377; 43964; 53001; 49561; 20060; 33032; 30505; 20739; 98160 +MAPK1 ERK2 P28482 human MEK1 5604 Q02750 MAP2K1 human T386 448288 IGLNQPstPtHAAGV X +MAPK1 ERK2 P28482 human TOP2A 7153 P11388 TOP2A human S1393 452242 GsVPLsssPPAtHFP X +MAPK1 ERK2 P28482 human DDHD1 338047 O46606 DDHD1 cow S730 465585 TIPSPVTsPVLSRRH DDHD X +MAPK1 ERK2 P28482 human E2A iso2 6929 P15923-2 TCF3 human T355 455166 NFSSsPStPVGsPQG X +MAPK1 ERK2 P28482 human MSK1 73086 Q8C050 Rps6ka5 mouse T645 448217 PDNQPLKtPCFTLHY Pkinase X 9595 +MAPK1 ERK2 P28482 human JMJD2B 23030 O94953 KDM4B human T305 484516 IDYGkVAtQCTCRKD X +MAPK1 ERK2 P28482 human EWS 2130 Q01844 EWSR1 human T79 7359501 QPPTGYTtPTAPQAY X X +MAPK1 ERK2 P28482 human SOX10 6663 P56693 SOX10 human T240 56655880 GQSHGPPtPPTtPkT X X +MAPK1 ERK2 P28482 human LIN28A 79727 Q9H9Z2 LIN28A human S200 7231811 EEEEEIHsPtLLPEA X 20607 +MAPK1 ERK2 P28482 human ERF 2077 P50548 ERF human S246 456967 RGGPEPLsPFPVsPL X X +MAPK1 ERK2 P28482 human Tau iso8 4137 P10636-8 MAPT human S422 449083 GsIDMVDsPQLAtLA X +MAPK1 ERK2 P28482 human BMF 90427 Q96LC9 BMF human S77 22999100 TQTLsPAsPSQGVML BMF X X +MAPK1 ERK2 P28482 human KHDRBS1 20218 Q60749 Khdrbs1 mouse S58 449876 PrGGArAsPAtQPPP X X +MAPK1 ERK2 P28482 human NUP153 9972 P49790 NUP153 human S522 3191092 tsPsstGsPMFKFSs Nup153 X +MAPK1 ERK2 P28482 human p300 2033 Q09472 EP300 human S2039 31828207 GLGQVGIsPLKPGTV Creb_binding X +MAPK1 ERK2 P28482 human Tau iso8 4137 P10636-8 MAPT human S235 449080 VVRtPPKsPssAKsR X 20473 +MAPK1 ERK2 P28482 human YTHDF2 51441 Q9Y5A9 YTHDF2 human T381 6223825 SQAGSGstPsEPHPV X +MAPK1 ERK2 P28482 human GLE1 2733 Q53GS7 GLE1 human S88 12667856 QPSFVPKsPDAssAF X +MAPK1 ERK2 P28482 human SREBP-2 6721 Q12772 SREBF2 human S455 451008 SIDSEPGsPLLDDAK X X +MAPK1 ERK2 P28482 human NR0B2 23957 Q62227 Nr0b2 mouse S26 7596703 TILYALLsPSPRTRP X X +MAPK1 ERK2 P28482 human NPAS4 225872 Q8BGD7 Npas4 mouse S577 1871095700 LYEKLPPsPSsPGNG X +MAPK1 ERK2 P28482 human K8 3856 P05787 KRT8 human S432 448540 sAyGGLtsPGLsysL X +MAPK1 ERK2 P28482 human PR 5241 P06401 PGR human S294 447987 APMAPGRsPLATTVM Prog_receptor X X 13736 +MAPK1 ERK2 P28482 human ADD1 118 P35611 ADD1 human S355 456832 kYKAKsRsPGsPVGE X X +MAPK1 ERK2 P28482 human PSD-95 29495 P31016 Dlg4 rat S290 469608 PtAMtPTsPRRYsPV PDZ_assoc X +MAPK1 ERK2 P28482 human p21Cip1 1026 P38936 CDKN1A human T57 451222 NFDFVtEtPLEGDFA CDI X X +MAPK1 ERK2 P28482 human SMAD2 4087 Q15796 SMAD2 human T220 448793 QSNYIPEtPPPGYIS X +MAPK1 ERK2 P28482 human p300 2033 Q09472 EP300 human S1038 10941006 STSATQssPAPGQsk X +MAPK1 ERK2 P28482 human TOP2A 7153 P11388 TOP2A human S1213 452237 QMAEVLPsPRGQRVI X +MAPK1 ERK2 P28482 human Jun 24516 P17325 Jun rat S246 450451 PGETPPLsPIDMESQ X 2994 +MAPK1 ERK2 P28482 human p53 7157 P04637 TP53 human T55 450685 DDIEQWFtEDPGPDE TAD2 X X +MAPK1 ERK2 P28482 human IEX-1 8870 P46695 IER3 human T18 455559 MTILQAPtPAPSTIP X X +MAPK1 ERK2 P28482 human C/EBP-beta 1051 P17676 CEBPB human T235 447878 SsssPPGtPSPADAK X X 3084 +MAPK1 ERK2 P28482 human DCP1A 75901 Q91YD3 Dcp1a mouse S335 3213294 PsYTLPLsPVLsPTL X +MAPK1 ERK2 P28482 human Bcl-6 604 P41182 BCL6 human S343 471422 KsDCQPNsPTESCSS X +MAPK1 ERK2 P28482 human eIF2-alpha 1965 P05198 EIF2S1 human S52 447635 MILLsELsRRRIRsI S1 X 3597; 9721; 3398; 5199; 53085; 95797 +MAPK1 ERK2 P28482 human Kv4.2 Q63881 Kcnd2 rat T602 457611 TAIISIPtPPVTtPE X +MAPK1 ERK2 P28482 human vinexin iso2 10174 O60504-2 SORBS3 human S188 452554 DGPQLPTsPRLTAAA X X +MAPK1 ERK2 P28482 human KHDRBS1 20218 Q60749 Khdrbs1 mouse T84 449878 tVVGSAPtPLLPPSA X +MAPK1 ERK2 P28482 human AML3 iso5 12393 Q08775-5 Runx2 mouse S319 10892802 SYLSQMTsPSIHSTt X +MAPK1 ERK2 P28482 human CDCA5 113130 Q96FF9 CDCA5 human S79 470691 AVQsPRRsPRIsFFL X +MAPK1 ERK2 P28482 human ADD2 119 P35612 ADD2 human S592 481588 tAPEEPGsPAksAPA X X +MAPK1 ERK2 P28482 human ERG 2078 P11308 ERG human S215 9429097 VDKALQNsPRLMHAR X X +MAPK1 ERK2 P28482 human DUSP1 1843 P28562 DUSP1 human S296 457717 kQRRSIIsPNFSFMG DSPc X X +MAPK1 ERK2 P28482 human 4E-BP1 116636 Q62622 Eif4ebp1 rat T69 447528 RNsPVAKtPPKDLPT eIF_4EBP X 9455 +MAPK1 ERK2 P28482 human p300 328572 B2RWS6 Ep300 mouse S2364 486264 MEQGHFAsPDQNSML X X +MAPK1 ERK2 P28482 human SOS1 6654 Q07889 SOS1 human S1167 451314 EsAPAEssPsKIMSK X +MAPK1 ERK2 P28482 human HIF2A 2034 Q99814 EPAS1 human S484 1876807202 SSCSTPNsPEDYYTS X +MAPK1 ERK2 P28482 human AR 367 P10275 AR human S516 452166 VSRVPYPsPTCVkSE X +MAPK1 ERK2 P28482 human p300 328572 B2RWS6 Ep300 mouse S2312 486263 RsPQPVPsPRPQsQP X X +MAPK1 ERK2 P28482 human STF-1 2516 Q13285 NR5A1 human S203 447603 EYPEPYAsPPQPGLP X +MAPK1 ERK2 P28482 human NANOG 79923 Q9H9S0 NANOG human S65 31960311 MDLLIQDsPDsStsP X +MAPK1 ERK2 P28482 human EXOC7 23265 Q9UPT5 EXOC7 human S250 483909 sSSGVPysPAIPNKR X X +MAPK1 ERK2 P28482 human TH 21823 P24529 Th mouse S31 448544 KQAEAVtsPRFIGRR TOH_N X 3370; 13041 +CDK14 CDK14 O94921 human LRP6 4040 O75581 LRP6 human S1490 456289 AILNPPPsPAtERsH X 2568 +CDK14 CDK14 O94921 human CBCP1 219771 Q8ND76 CCNY human S73 3850500 stIFLsksQtDVREK X X +CDK14 CDK14 O94921 human CBCP1 219771 Q8ND76 CCNY human S71 4750438 RAstIFLsksQtDVR X X +CDK14 CDK14 O94921 human CBCP1 219771 Q8ND76 CCNY human S83 4750444 DVREKRKsLFINHHP X +CDK14 CDK14 O94921 human PPP1R2 5504 P41236 PPP1R2 human S87 449054 GDDEDACsDtEAtEA IPP-2 X +CDK14 CDK14 O94921 human LRP6 16974 O88572 Lrp6 mouse S1490 456289 AILNPPPsPAtERSH X 2568 +CDK14 CDK14 O94921 human CBCP1 219771 Q8ND76 CCNY human S295 31000122 sFPLEPLsRERAHkL X +CDK14 CDK14 O94921 human CBCP1 219771 Q8ND76 CCNY human S288 31000119 LAEANNLsFPLEPLs X +CDK14 CDK14 O94921 human TAGLN2 8407 P37802 TAGLN2 human S83 19083400 PVkkIQAstMAFkQM CH X +CDK14 CDK14 O94921 human CBCP1 219771 Q8ND76 CCNY human T67 20651051 SDHPRAstIFLsksQ X +CDK14 CDK14 O94921 human TAGLN2 8407 P37802 TAGLN2 human S163 468770 kENPRNFsDNQLQEG X +Pak4 PAK4 Q8BTW9 mouse PPAR-gamma 19016 P37238 Pparg mouse S273 15175800 TGkTTDKsPFVIYDM X +Pak4 PAK4 Q8BTW9 mouse MRLC2 67938 Q3THE2 Myl12b mouse S20 448595 KRPQRAtsNVFAMFD X +GSK3B GSK3B iso2 P49841-2 human MAP1B 17755 P14873 Map1b mouse S1260 454136 sLsPsPPsPIEKtPL X X +GSK3B GSK3B iso2 P49841-2 human GSK3B iso2 2932 P49841-2 GSK3B human Y216 448569 RGEPNVSyICSRYYR Pkinase X +GSK3A GSK3A P49840 human PPAR-alpha 5465 Q07869 PPARA human S280 1867858200 FHCCQCTsVETVTEL Hormone_recep X +GSK3A GSK3A P49840 human Tau iso8 4137 P10636-8 MAPT human T231 449079 KKVAVVRtPPKsPss X 20473; 71429 +GSK3A GSK3A P49840 human GRB14 2888 Q14449 GRB14 human S362 31834912 QGRsGCSsQSIsPMR X X +GSK3A GSK3A P49840 human Tau iso8 4137 P10636-8 MAPT human S199 447927 GDRsGyssPGsPGtP X 29957 +GSK3A GSK3A P49840 human LRP6 4040 O75581 LRP6 human S1544 21009101 CDSDyAPsRRMtSVA X +GSK3A GSK3A P49840 human IRF3 3661 Q14653 IRF3 human T180 28095000 sPsLDNPtPFPNLGP X +GSK3A GSK3A P49840 human MAFA 389692 Q8NHW3 MAFA human S61 1320401 PLStPCSsVPSsPSF X +GSK3A GSK3A P49840 human NBR1 4077 Q14596 NBR1 human T586 33602700 HNtPVDVtPCMsPLP X X +GSK3A GSK3A P49840 human NFM 24588 P12839 Nefm rat S507 448042 VEKsPVKsPEAKEEE X +GSK3A GSK3A P49840 human SMAD2 Q1W668 SMAD2 cow S245 448794 NQSMDTGsPAELsPT X +GSK3A GSK3A P49840 human C/EBP-alpha 12606 P53566 Cebpa mouse T222 449824 HLQPGHPtPPPtPVP X X 2844 +GSK3A GSK3A P49840 human FBXL20 84961 Q96IG2 FBXL20 human T417 467016 HAYFAPVtPPPsVGG X X +GSK3A GSK3A P49840 human GSK3A 2931 P49840 GSK3A human Y279 447723 RGEPNVsyICsRyyR Pkinase X +GSK3A GSK3A P49840 human STAT2 6773 P52630 STAT2 human S393 1869778702 LtPEKGQsQGLIWDF STAT_bind X X +GSK3A GSK3A P49840 human TBX21 57765 Q9JKD8 Tbx21 mouse S508 458229 PsSGDSSsPAGAPsP X +GSK3A GSK3A P49840 human desmin 1674 P17661 DES human S32 466343 PLGsPLssPVFPrAG Filament_head X +GSK3A GSK3A P49840 human CTNNB1 1499 P35222 CTNNB1 human S37 447582 yLDsGIHsGATtTAP X 9561; 2009; 4270; 13537; 41334; 60180 +GSK3A GSK3A P49840 human FBXL20 84961 Q96IG2 FBXL20 human S251 1875005604 RGCHKLQsLCAsGCS X X +GSK3A GSK3A P49840 human Tau iso8 4137 P10636-8 MAPT human S396 449081 GAEIVyKsPVVsGDt X 9632 +GSK3A GSK3A P49840 human FBXL20 84961 Q96IG2 FBXL20 human S255 1875005606 KLQsLCAsGCSNITD X X +GSK3A GSK3A P49840 human IL17RA 16172 Q60943 Il17ra mouse T779 41452470 EVVLEGCtPSEEEQR X +GSK3A GSK3A P49840 human NDRG1 10397 Q92597 NDRG1 human S362 454250 HtsEGtRsRsHtsEG X +GSK3A GSK3A P49840 human C/EBP-alpha 12606 P53566 Cebpa mouse T226 449825 GHPtPPPtPVPsPHA X X 2844 +GSK3A GSK3A P49840 human Tau iso8 4137 P10636-8 MAPT human S404 449082 PVVsGDtsPRHLsNV X 35834; 20194; 98523; 91600; 49562 +GSK3A GSK3A P49840 human MITF iso9 4286 O75030-9 MITF human S298 448503 QARAHGLsLIPSTGL DUF3371 X +GSK3A GSK3A P49840 human MAFA 389692 Q8NHW3 MAFA human T57 456028 LSStPLStPCSsVPS X +GSK3A GSK3A P49840 human CdGAP 12549 A6X8Z5 Arhgap31 mouse T776 456517 tPAPPPPtPLEEEPE X X +GSK3A GSK3A P49840 human Tau iso8 4137 P10636-8 MAPT human S262 447930 NVKskIGstENLkHQ Tubulin-binding X +GSK3A GSK3A P49840 human LRP6 4040 O75581 LRP6 human S1490 456289 AILNPPPsPAtERsH X 2568 +GSK3A GSK3A P49840 human MAFA 389692 Q8NHW3 MAFA human S49 1320400 CHRLPPGsLSStPLS X +GSK3A GSK3A P49840 human RICTOR 253260 Q6R327 RICTOR human T1695 40638601 EAEAVLAtPPKQPIV X +GSK3A GSK3A P49840 human FBXL20 84961 Q96IG2 FBXL20 human S139 1875005600 DATCTSLskFCsKLR X X +GSK3A GSK3A P49840 human Myc 4609 P01106 MYC human T73 448496 kkFELLPtPPLsPsR Myc_N X 46650 +GSK3A GSK3A P49840 human NIFK 84365 Q9BYG3 NIFK human S230 457632 tPEKtVDsQGPtPVC hNIFK_binding X +GSK3A GSK3A P49840 human STAT3 6774 P40763 STAT3 human S727 448191 NtIDLPMsPrTLDSL X 9134; 9136; 34911; 94994; 49081; 58978; 87544; 71958; 50804 +GSK3A GSK3A P49840 human desmin 1674 P17661 DES human S28 4705787 APGFPLGsPLssPVF Filament_head X +GSK3A GSK3A P49840 human desmin Q5XFN2 DES dog S32 466343 PLGsPLGsPVFPRAG Filament_head X +GSK3A GSK3A P49840 human PD-L1 29126 Q9NZQ7 CD274 human S279 1872811800 CGIQDTNsKkQsDtH X X +GSK3A GSK3A P49840 human FBXL20 84961 Q96IG2 FBXL20 human S425 4149424 PPPsVGGsRQRFCRC X X +GSK3A GSK3A P49840 human Bcl-xL 598 Q07817 BCL2L1 human S62 449099 PSWHLADsPAVNGAT X +GSK3A GSK3A P49840 human OSBP2 23762 Q969R2 OSBP2 human S762 11171320 ECSKVMHssPssPsS Oxysterol_BP X +GSK3A GSK3A P49840 human UNG 7374 P13051 UNG human S64 2018601 EPGtPPssPLsAEQL X +GSK3A GSK3A P49840 human GPSM3 63940 Q9Y4H4 GPSM3 human S35 4717965 STTRPWRsAPPsPPP X +GSK3A GSK3A P49840 human SMAD2 Q1W668 SMAD2 cow T220 448793 QSNYIPEtPPPGYIS X +GSK3A GSK3A P49840 human STMN3 50861 Q9NZ72 STMN3 human S60 4698871 sFEVILksPSDLsPE Stathmin X +GSK3A GSK3A P49840 human OSBP2 23762 Q969R2 OSBP2 human S766 15721694 VMHssPssPsSDGKQ Oxysterol_BP X +GSK3A GSK3A P49840 human UNG 7374 P13051 UNG human T60 452622 AGQEEPGtPPssPLs X +GSK3A GSK3A P49840 human FBXL20 84961 Q96IG2 FBXL20 human S143 1875005602 TSLskFCsKLRHLDL LRR_6 X X +GSK3A GSK3A P49840 human STAT3 6774 P40763 STAT3 human T714 3190177 ktKFICVtPTtCsNt X +GSK3A GSK3A P49840 human STAT2 6773 P52630 STAT2 human T385 1869778701 ILTsNQktLtPEKGQ STAT_bind X X +GSK3A GSK3A P49840 human CRMP-2 1808 Q16555 DPYSL2 human S518 448081 ktVtPAssAktsPAk X +GSK3A GSK3A P49840 human IRF3 3661 Q14653 IRF3 human S123 4712212 DFSQPDTsPDTNGGG X +GSK3A GSK3A P49840 human CRMP-2 25416 P47942 Dpysl2 rat T514 454386 SVtPKTVtPASsAKT X 9397 +GSK3A GSK3A P49840 human MAFA 389692 Q8NHW3 MAFA human T53 1320402 PPGsLSStPLStPCS X +GSK3A GSK3A P49840 human AMPKA1 5562 Q13131 PRKAA1 human T490 3195170 EAksGtAtPQRsGsV AdenylateSensor X +GSK3A GSK3A P49840 human SMAD2 Q1W668 SMAD2 cow S255 448796 ELsPTTLsPVNHSLD X +GSK3A GSK3A P49840 human EEF2K 25435 P70531 Eef2k rat S391 4696253 MSDVTFDsLPSsPSS X +GSK3A GSK3A P49840 human CRMP-2 25416 P47942 Dpysl2 rat S522 448082 PASsAKTsPAKQQAP X +GSK3A GSK3A P49840 human PD-L1 29126 Q9NZQ7 CD274 human S283 14735979 DTNsKkQsDtHLEEt X +GSK3A GSK3A P49840 human STAT2 6773 P52630 STAT2 human S381 1869778700 RkFNILTsNQktLtP STAT_bind X X +GSK3A GSK3A P49840 human desmin Q5XFN2 DES dog S28 4705787 AGGFPLGsPLGsPVF Filament_head X +GSK3A GSK3A P49840 human GRB14 2888 Q14449 GRB14 human S358 31834913 MHPYQGRsGCSsQSI X X +GSK3A GSK3A P49840 human neurogenin 2 11924 P70447 Neurog2 mouse S231 2255101 SPYSCTLsPAsPGSD X +GSK3A GSK3A P49840 human Bcl-3 602 P20749 BCL3 human S402 3627521 LSASPSSsPSQsPPR X +GSK3A GSK3A P49840 human GRB14 2888 Q14449 GRB14 human S423 62887802 THGsPtAsSQSSATN X X +GSK3A GSK3A P49840 human NFM 24588 P12839 Nefm rat S503 448041 EEPEVEKsPVKsPEA X +GSK3A GSK3A P49840 human IL17RA 23765 Q96F46 IL17RA human T780 41452470 MVLTDPHtPYEEEQR X +GSK3A GSK3A P49840 human SRC-3 8202 Q9Y6Q9 NCOA3 human S509 482840 GVHsPMAsSGNTGNH NCOA_u2 X +GSK3A GSK3A P49840 human NFM 24588 P12839 Nefm rat S604 451836 EKPEKAKsPVPKsPV X +GSK3A GSK3A P49840 human Aiolos 22806 Q9UKT9 IKZF3 human S378 4696322 VPSERGLsPNNSGHD X +GSK3A GSK3A P49840 human PKAR2A 518399 P00515 PRKAR2A cow S48 466004 REARsRAsTPPAAPP X +GSK3A GSK3A P49840 human NDRG1 10397 Q92597 NDRG1 human S342 454248 tsLDGtRsRsHtsEG X +GSK3A GSK3A P49840 human CRMP-2 12934 O08553 Dpysl2 mouse T514 454386 sVtPktVtPAssAkt X 9397 +GSK3A GSK3A P49840 human Bcl-3 602 P20749 BCL3 human S406 3627522 PSSsPSQsPPRDPPG X +GSK3A GSK3A P49840 human PKAR2A 518399 P00515 PRKAR2A cow S45 466003 TRLREARsRAsTPPA RIIa X +GSK3A GSK3A P49840 human DYN2 13430 P39054 Dnm2 mouse S848 3059607 GIPPGVPsRRAPAAP X X +GSK3A GSK3A P49840 human neurogenin 2 11924 P70447 Neurog2 mouse S234 2255100 SCTLsPAsPGSDVDy X +GSK3A GSK3A P49840 human GRB14 2888 Q14449 GRB14 human S419 24986639 LRLGTHGsPtAsSQS X X +GSK3A GSK3A P49840 human CCNE1 898 P24864 CCNE1 human T395 447676 PLPSGLLtPPQsGKK X +GSK3A GSK3A P49840 human OSBP2 23762 Q969R2 OSBP2 human S768 15721697 HssPssPsSDGKQKT Oxysterol_BP X +GSK3A GSK3A P49840 human CTNND1 311163 D3ZZZ9 Ctnnd1 rat T310 450457 GTARRTGtPSDPRRR X +GSK3A GSK3A P49840 human GR 24413 P06536 Nr3c1 rat T171 451795 TSATGCAtPTEKEFP GCR X +GSK3A GSK3A P49840 human CRMP-2 25416 P47942 Dpysl2 rat S518 448081 KTVtPASsAKTsPAK X +GSK3A GSK3A P49840 human LRP6 4040 O75581 LRP6 human S1607 21241903 HLYPPPPsPCTDss_ X +GSK3A GSK3A P49840 human CTNNB1 1499 P35222 CTNNB1 human S33 447487 QQQsyLDsGIHsGAT X 9561; 2009; 4270; 13537; 41334; 60180 +GSK3A GSK3A P49840 human LRP6 4040 O75581 LRP6 human T1572 3802448 EPVPPPPtPRsQyLs X +GSK3A GSK3A P49840 human OSBP2 23762 Q969R2 OSBP2 human S763 31727226 CSKVMHssPssPsSD Oxysterol_BP X +GSK3A GSK3A P49840 human NFM 24588 P12839 Nefm rat S667 448045 PDKKKAEsPVKEKAV X +GSK3A GSK3A P49840 human CTNNB1 1499 P35222 CTNNB1 human T41 447583 GIHsGATtTAPsLsG X 9561; 9565; 4270; 13537; 41334; 60180 +GSK3A GSK3A P49840 human SMAD2 Q1W668 SMAD2 cow S250 448795 TGsPAELsPTTLsPV X +GSK3A GSK3A P49840 human NDRG1 10397 Q92597 NDRG1 human S352 454249 HtsEGtRsRsHtsEG X +GSK3A GSK3A P49840 human PKD2 5311 Q13563 PKD2 human S76 460685 AGAAAsPsPPLsSCS X X +GSK3A GSK3A P49840 human IRS2 384783 P81122 Irs2 mouse S484 1308919 RPSSGSAsASGsPSD X +GSK3A GSK3A P49840 human PI4K2A 84095 Q2TBE6 Pi4k2a mouse S5 2022753 ___MDETsPLVsPER X +GSK3A GSK3A P49840 human PI4K2A 84095 Q2TBE6 Pi4k2a mouse S47 468434 AAAGsGPsPPCsPGH X +GSK3A GSK3A P49840 human ANKRD28 23243 O15084 ANKRD28 human S1007 459224 INRyTNTskTVsFEA X +GSK3A GSK3A P49840 human NIFK 84365 Q9BYG3 NIFK human T234 449332 tVDsQGPtPVCtPtF hNIFK_binding X +GSK3A GSK3A P49840 human FBXL20 84961 Q96IG2 FBXL20 human S421 467840 APVtPPPsVGGsRQR X X +GSK3A GSK3A P49840 human GRB14 2888 Q14449 GRB14 human S366 29576856 GCSsQSIsPMRsIsE X X +GSK3A GSK3A P49840 human Tau iso8 4137 P10636-8 MAPT human S235 449080 VVRtPPKsPssAKsR X 20473 +GSK3A GSK3A P49840 human IRF3 3661 Q14653 IRF3 human S173 6370303 PCPQPLRsPsLDNPt X +GSK3A GSK3A P49840 human p21Cip1 1026 P38936 CDKN1A human T57 451222 NFDFVtEtPLEGDFA CDI X +GSK3A GSK3A P49840 human Akt1 207 P31749 AKT1 human T312 5862771 tMKtFCGtPEyLAPE Pkinase X X +GSK3A GSK3A P49840 human Doublecortin iso3 13193 Q9CXL6 Dcx mouse S327 451363 StPKSKQsPIstPts X +GSK3A GSK3A P49840 human CRMP-2 25416 P47942 Dpysl2 rat T509 448083 PVCEVSVtPKTVtPA X +GSK3A GSK3A P49840 human SRC-3 8202 Q9Y6Q9 NCOA3 human S505 454109 SPVAGVHsPMAsSGN NCOA_u2 X +CDK18 CDK18 Q07002 human Rb 5925 P06400 RB1 human S795 447979 sPykFPssPLrIPGG Rb_C X 9301 +CDK18 CDK18 Q07002 human Rb 5925 P06400 RB1 human S807 447980 PGGNIyIsPLksPyk Rb_C X 9308; 8974; 4277; 40283; 8957; 8516; 11917; 99274; 41359; 75864; 72443 +CDK18 CDK18 Q07002 human Rb 5925 P06400 RB1 human S811 448717 IyIsPLksPykIsEG Rb_C X 9308; 8974; 4277; 40283; 8957; 8516; 11917; 41359; 75864; 63276 +PDK2 PDHK2 Q15119 human PDHA1 5160 P08559 PDHA1 human S300 448259 sMsDPGVsyRtREEI E1_dh X +PDK2 PDHK2 Q15119 human PDHA1 5160 P08559 PDHA1 human S293 448258 TYRyHGHsMsDPGVs E1_dh X 31866; 37115; 48447 +PDK2 PDHK2 Q15119 human PDHA2 5161 P29803 PDHA2 human S298 458870 sMsDPGVsyRtREEI E1_dh X +PDK2 PDHK2 Q15119 human PDHA1 5160 P08559 PDHA1 human S232 448257 NRyGMGtsVERAAAs E1_dh X 15289 +PDK2 PDHK2 Q15119 human PDHA2 5161 P29803 PDHA2 human S291 458869 TYRyHGHsMsDPGVs E1_dh X 31866; 37115; 48447 +PDK2 PDHK2 Q15119 human PDHA1 18597 P35486 Pdha1 mouse S232 448257 NRyGMGtsVERAAAS E1_dh X +PRKACA PKACA iso2 P17612-2 human SEPT12 124404 Q8IYM1 SEPTIN12 human S198 63250400 PVIARADsLTMEERE Septin X +TSSK4 TSSK4 Q6SA08 human HSP90B 15516 P11499 Hsp90ab1 mouse S255 449266 PKIEDVGsDEEDDsG HSP90 X X +TSSK4 TSSK4 Q6SA08 human CREB 1385 P16220 CREB1 human S119 448228 EILsRRPsyRkILND pKID X 9187; 9196; 9198; 4095; 14228; 14001; 39561; 80120; 44864; 54960; 95995 +Oxsr1 OSR1 NP_001101664 rat NCCT 54300 P55018 Slc12a3 rat T58 469617 LRtFGYNtIDVVPAY AA_permease_N X +LIMK2 LIMK2 P53671 human Destrin 11034 P60981 DSTN human S3 449754 _____MAsGVQVADE X +LIMK2 LIMK2 P53671 human Cofilin-1 29271 P45592 Cfl1 rat S3 448444 _____MAsGVAVsDG X 3313; 3311 +LIMK2 LIMK2 P53671 human Cofilin-1 1072 P23528 CFL1 human S3 448444 _____MAsGVAVsDG X X 3313; 3311 +LIMK2 LIMK2 P53671 human G3BP-1 10146 Q13283 G3BP1 human S149 449041 VtEPQEEsEEEVEEP X +EPHB1 EphB1 P54762 human syndecan-3 P33671 Sdc3 rat Y441 458439 PDKQEEFyA______ X +EPHB1 EphB1 P54762 human CASKIN1 140722 Q8VHK2 Caskin1 rat Y296 472784 TKDYCNNyDLTSLNV SH3_2 X +EPHB1 EphB1 P54762 human GJB1 2705 P08034 GJB1 human Y243 3559630 GHRLsPEyKQNEINk X X +EPHB1 EphB1 P54762 human STAT3 20848 P42227 Stat3 mouse Y705 448192 DPGsAAPyLktkFIC X 4093; 9145; 4324; 9131; 9138; 4323; 4074; 4113; 48313; 20977; 25023; 8119; 52075; 52527; 73533; 61958; 73452; 16185; 74309 +EPHB1 EphB1 P54762 human CASKIN1 140722 Q8VHK2 Caskin1 rat Y336 4274896 TGNDRVGyFPSSLGE SH3_2 X +Mtor mTOR Q9JLN9 mouse CRMP-4 22240 Q62188 Dpysl3 mouse S522 458800 PAGstRGsPtRPNPP X +Mtor mTOR Q9JLN9 mouse DENND2B 76954 Q924W7 Dennd2b mouse S42 8145389 PVLYPPRsPIYPLsD X +Mtor mTOR Q9JLN9 mouse MRCKB 217866 Q7TT50 Cdc42bpb mouse S1692 468206 SNPsGPPsPNsPHRS X +Mtor mTOR Q9JLN9 mouse TBC1D10B 68449 Q8BHL3 Tbc1d10b mouse S643 2024345 QPPLGPsssLLsLPs X +Mtor mTOR Q9JLN9 mouse OTUD5 54644 Q3U2S4 Otud5 mouse S323 1870773108 EDEPIRVsYHRNIHY OTU X X +Mtor mTOR Q9JLN9 mouse 4E-BP1 13685 Q60876 Eif4ebp1 mouse S64 447527 FLMECRNsPVAKtPP eIF_4EBP X 9451; 9456 +Mtor mTOR Q9JLN9 mouse eIF4G 208643 Q6NZJ6 Eif4g1 mouse T212 469248 SGARtAstPtPPQtG X +Mtor mTOR Q9JLN9 mouse IGF2BP1 140486 O88477 Igf2bp1 mouse S181 453893 RGQPRQGsPVAAGAP X +Mtor mTOR Q9JLN9 mouse CHFR 231600 Q810L3 Chfr mouse S231 20651127 NGELSSLsPVFQDKE X +Mtor mTOR Q9JLN9 mouse LPIN1 14245 Q91ZP3 Lpin1 mouse S472 471355 GARsANQsPQsVGGs X +Mtor mTOR Q9JLN9 mouse C1orf131 66523 Q8CIL4 2810004N23Rik mouse S67 478543 EPLPLPGsPVRGQKK X +Mtor mTOR Q9JLN9 mouse mTOR 56717 Q9JLN9 Mtor mouse S2481 447498 tVPEsIHsFIGDGLV X 2974 +Mtor mTOR Q9JLN9 mouse 4E-BP1 13685 Q60876 Eif4ebp1 mouse T45 447496 GGtLFsttPGGtRII eIF_4EBP X X 2855; 9459; 2846; 4923; 5123; 3929; 7547; 45613; 39788 +Mtor mTOR Q9JLN9 mouse FOXK1 17425 P42128 Foxk1 mouse S427 467911 LQtPECLsREGsPIP X +Mtor mTOR Q9JLN9 mouse GRB10 14783 Q60760 Grb10 mouse S104 20651543 PPsVAPssLPPPPSQ X +Mtor mTOR Q9JLN9 mouse PKCB iso2 18751 P68404-2 Prkcb mouse T634 448592 ENFDRFFtRHPPVLt Pkinase_C X X +Mtor mTOR Q9JLN9 mouse ataxin-2L 233871 Q7TQH0 Atxn2l mouse S32 3207780 RRsPGGtsPPNGGLP X +Mtor mTOR Q9JLN9 mouse USP20 74270 Q8C6M1 Usp20 mouse S134 469014 ADEGEsEsEDDDLKP X +Mtor mTOR Q9JLN9 mouse AHNAK 66395 E9Q616 Ahnak mouse S5525 452764 ssKAsLGsLEGEVEA X +Mtor mTOR Q9JLN9 mouse Akt1 207 P31749 AKT1 human S473 447855 RPHFPQFsysAsGtA Pkinase_C X 9271; 3787; 4060; 4051; 5102; 4058; 2336; 2337; 4075; 4070; 5012; 4071; 92982; 5315; 9563; 9018; 12694; 52240; 11962; 15116; 88106; 26580; 68035; 31957; 23430; 20235 +Mtor mTOR Q9JLN9 mouse CUTL1 13047 P53564 Cux1 mouse S882 8110780 KEWPSAEsPYsQSSE X +Mtor mTOR Q9JLN9 mouse nestin 18008 Q6P5H2 Nes mouse S919 4738507 KTHEILGsLEDRNGE X +Mtor mTOR Q9JLN9 mouse PRAS40 84335 Q96B36 AKT1S1 human S183 482839 PTQQYAKsLPVSVPV PRAS X 5936 +Mtor mTOR Q9JLN9 mouse NuMA-1 101706 E9Q7G0 Numa1 mouse T1982 459921 EtHQGPGtPEsKKAT X +Mtor mTOR Q9JLN9 mouse FASN 14104 P19096 Fasn mouse T1029 27930800 LWKDNWVtFMDtMLQ PS-DH X +Mtor mTOR Q9JLN9 mouse AHNAK 66395 E9Q616 Ahnak mouse S5553 465634 sKKPRHRsNsFsDER X +Mtor mTOR Q9JLN9 mouse RC3H1 381305 Q4VGL6 Rc3h1 mouse S535 3199145 LsssAPGsPPDLLES X +Mtor mTOR Q9JLN9 mouse IRS1 16367 P35569 Irs1 mouse S635 447507 yMPMsPKsVsAPQQI X 2388 +Mtor mTOR Q9JLN9 mouse 4E-BP2 13688 P70445 Eif4ebp2 mouse T41 449368 yCttPGGtLFsttPG eIF_4EBP X +Mtor mTOR Q9JLN9 mouse LPIN1 14245 Q91ZP3 Lpin1 mouse S106 471342 IPMYLATsPILsEGA Lipin_N X +Mtor mTOR Q9JLN9 mouse ataxin-2L 233871 Q7TQH0 Atxn2l mouse T31 3207795 ARRsPGGtsPPNGGL X +Mtor mTOR Q9JLN9 mouse AFAP 70292 Q80YS6 Afap1 mouse S666 459648 EPRSGTssPQsPVFR X +Mtor mTOR Q9JLN9 mouse TBC1D10B 68449 Q8BHL3 Tbc1d10b mouse S650 4750805 ssLLsLPsLKSRGSR X +Mtor mTOR Q9JLN9 mouse ARHGAP29 214137 Q8CGF1 Arhgap29 mouse S1040 17556431 RLLLLASsPtERSSR X +Mtor mTOR Q9JLN9 mouse EHMT2 110147 Q9Z148 Ehmt2 mouse S287 14570379 RRKLNsGsLsEDLGs X +Mtor mTOR Q9JLN9 mouse PTPN13 19249 Q64512 Ptpn13 mouse S1077 10941795 KRWsIVssPEREITL X +Mtor mTOR Q9JLN9 mouse LARP 73158 Q6ZQ58 Larp1 mouse S751 453830 LPttVPEsPNyRNAR X +Mtor mTOR Q9JLN9 mouse STAT3 6774 P40763 STAT3 human S727 448191 NtIDLPMsPrTLDSL X 9134; 9136; 34911; 94994; 49081; 58978; 87544; 71958; 50804 +Mtor mTOR Q9JLN9 mouse SMCR8 237782 Q3UMB5 Smcr8 mouse S416 484908 KVLIsVGsYKssVEs X +Mtor mTOR Q9JLN9 mouse PKCH 18755 P23298 Prkch mouse S642 1239966008 IKSREDVsNFDPDFI Pkinase_C X X +Mtor mTOR Q9JLN9 mouse OTUD5 54644 Q3U2S4 Otud5 mouse S332 1870773110 HRNIHYNsVVNPNKA OTU X X +Mtor mTOR Q9JLN9 mouse DENND2B 76954 Q924W7 Dennd2b mouse S32 4770691 LSRsQsVsPPPVLYP X +Mtor mTOR Q9JLN9 mouse STAT3 20848 P42227 Stat3 mouse S727 448191 NtIDLPMsPRTLDSL X 9134; 9136; 34911; 94994; 49081; 58978; 87544; 71958; 50804 +Mtor mTOR Q9JLN9 mouse NUP188 227699 Q6ZQH8 Nup188 mouse T1515 20652092 DGLPSAVtPRAQRPs X +Mtor mTOR Q9JLN9 mouse LARP 73158 Q6ZQ58 Larp1 mouse S743 483150 EPStIARsLPttVPE X +Mtor mTOR Q9JLN9 mouse TAF140 209361 Q5HZG4 Taf3 mouse S229 453776 QKtPPVLsPVRVQDR X +Mtor mTOR Q9JLN9 mouse C1orf131 66523 Q8CIL4 2810004N23Rik mouse T53 4760272 AKKRDsEtIEDVAVE X +Mtor mTOR Q9JLN9 mouse PATL1 225929 Q3TC46 Patl1 mouse T194 17599503 VRAVPIGtPPKQMAV X +Mtor mTOR Q9JLN9 mouse POLR2A 20020 P08775 Polr2a mouse S1934 452275 sPtysPtsPKGSTYS RNA_pol_Rpb1_R X +Mtor mTOR Q9JLN9 mouse IRS1 16367 P35569 Irs1 mouse S632 447506 NGDyMPMsPKsVsAP X 2388 +Mtor mTOR Q9JLN9 mouse PRAS40 84335 Q96B36 AKT1S1 human S212 453462 EENGPPssPDLDRIA PRAS X +Mtor mTOR Q9JLN9 mouse PHLDB2 208177 Q8K1N2 Phldb2 mouse S17 20652239 QLEFQNGsLEEGFVV X +Mtor mTOR Q9JLN9 mouse 4E-BP1 1978 Q13541 EIF4EBP1 human S65 447527 FLMECrNsPVtktPP eIF_4EBP X 9451; 9456; 13443 +Mtor mTOR Q9JLN9 mouse FOXK2 68837 Q3UCQ1 Foxk2 mouse S389 483637 EsLsREGsPAPLEPE X +Mtor mTOR Q9JLN9 mouse GRB10 14783 Q60760 Grb10 mouse S103 20651540 sPPsVAPssLPPPPS X +Mtor mTOR Q9JLN9 mouse 4E-BP1 13685 Q60876 Eif4ebp1 mouse T69 447528 RNsPVAKtPPKDLPA eIF_4EBP X 9455 +Mtor mTOR Q9JLN9 mouse PTPN13 19249 Q64512 Ptpn13 mouse S1073 4169805 DTLHKRWsIVssPER X +Mtor mTOR Q9JLN9 mouse DDX18 66942 Q8K363 Ddx18 mouse T101 4762180 ANGEAAPtPPPDSEV X +Mtor mTOR Q9JLN9 mouse IRS2 384783 P81122 Irs2 mouse S616 483512 CPSFPASsPKVAYNP X +Mtor mTOR Q9JLN9 mouse DLG5 71228 E9Q9R9 Dlg5 mouse S1209 11537655 HRVLPCGsPPVPRDA X +Mtor mTOR Q9JLN9 mouse 4E-BP1 13685 Q60876 Eif4ebp1 mouse T36 447497 PPGDysttPGGtLFs eIF_4EBP X X 2855; 9459; 2846; 4923; 5123; 3929; 7547; 45613; 39788 +Mtor mTOR Q9JLN9 mouse p70S6K 6198 P23443 RPS6KB1 human S394 448806 TRQtPVDsPDDStLS Pkinase_C X 9208 +Mtor mTOR Q9JLN9 mouse IRS1 16367 P35569 Irs1 mouse S307 447558 tEsITAtsPAsMVGG X 2381 +Mtor mTOR Q9JLN9 mouse NFRKB 235134 Q6PIJ4 Nfrkb mouse S351 453698 PTLsQAPsPLAISSI X +Mtor mTOR Q9JLN9 mouse USP20 74270 Q8C6M1 Usp20 mouse S132 469013 AVADEGEsEsEDDDL X +Mtor mTOR Q9JLN9 mouse WIPI2 74781 Q80W47 Wipi2 mouse S395 3217428 KGAYVPssPtRLGKG X 13571 +Mtor mTOR Q9JLN9 mouse PHLDB1 102693 Q6PDH0 Phldb1 mouse S1007 20652230 SVATLGRsPsPKSAL X +Mtor mTOR Q9JLN9 mouse FASN 14104 P19096 Fasn mouse T1033 27930801 NWVtFMDtMLQVSIL PS-DH X +Mtor mTOR Q9JLN9 mouse FOXK1 17425 P42128 Foxk1 mouse S431 467912 ECLsREGsPIPHDPD X +Mtor mTOR Q9JLN9 mouse NFAT3 73181 Q8K120 Nfatc4 mouse S170 448860 GGAFFsPsPGSSSLS X +Mtor mTOR Q9JLN9 mouse SZT2 230676 A2A9C3 Szt2 mouse S3230 14575118 TPGSLVGsPREASGM X +Mtor mTOR Q9JLN9 mouse MCL1 17210 P97287 Mcl1 mouse T144 455375 ADGsLPStPPPPEEE X 4579 +Mtor mTOR Q9JLN9 mouse AFAP 70292 Q80YS6 Afap1 mouse S665 3206235 IEPRSGTssPQsPVF X +Mtor mTOR Q9JLN9 mouse NuMA-1 101706 E9Q7G0 Numa1 mouse S1974 487252 QQRKRVssEtHQGPG X +Mtor mTOR Q9JLN9 mouse 4E-BP1 1978 Q13541 EIF4EBP1 human T37 447497 PPGDysttPGGtLFs eIF_4EBP X 2855; 9459; 2846; 5123; 3929; 7547; 45613; 39788 +Mtor mTOR Q9JLN9 mouse MAP1B 17755 P14873 Map1b mouse S1260 454136 sLsPsPPsPIEKtPL X +Mtor mTOR Q9JLN9 mouse TIF1B 10155 Q13263 TRIM28 human S824 460839 LPGAGLssQELsGGP X 4127 +Mtor mTOR Q9JLN9 mouse MAP1B 17755 P14873 Map1b mouse S1247 456401 DVsDERLsPAKsPsL X +Mtor mTOR Q9JLN9 mouse PRAS40 84335 Q96B36 AKT1S1 human S221 2506802 DLDRIAAsMRALVLR PRAS X +Mtor mTOR Q9JLN9 mouse PHLDB1 102693 Q6PDH0 Phldb1 mouse S1009 4739736 ATLGRsPsPKSALLA X +Mtor mTOR Q9JLN9 mouse TIF1B 10155 Q13263 TRIM28 human S473 452391 sGVkRsRsGEGEVsG X +Mtor mTOR Q9JLN9 mouse 4E-BP2 13688 P70445 Eif4ebp2 mouse T37 449367 LPQDyCttPGGtLFs eIF_4EBP X +Mtor mTOR Q9JLN9 mouse Akt1 11651 P31750 Akt1 mouse S473 447855 RPHFPQFsysAsGtA Pkinase_C X 9271; 3787; 4060; 4051; 5102; 4058; 2336; 2337; 4075; 4070; 5012; 4071; 92982; 5315; 9563; 9018; 12694; 52240; 11962; 15116; 88106; 26580; 68035; 31957; 23430; 20235 +Mtor mTOR Q9JLN9 mouse Jun 16476 P05627 Jun mouse T242 450450 VPEMPGEtPPLsPID Jun X +Mtor mTOR Q9JLN9 mouse AHNAK 66395 E9Q616 Ahnak mouse S5536 483522 EVEAEAssPKGKFsL X +Mtor mTOR Q9JLN9 mouse Jun 16476 P05627 Jun mouse S246 450451 PGEtPPLsPIDMESQ X 2994 +Mtor mTOR Q9JLN9 mouse DENND2B 76954 Q924W7 Dennd2b mouse S30 4770685 ETLSRsQsVsPPPVL X +Mtor mTOR Q9JLN9 mouse AFAP 70292 Q80YS6 Afap1 mouse S669 453460 SGTssPQsPVFRHRt X +Mtor mTOR Q9JLN9 mouse 4E-BP1 1978 Q13541 EIF4EBP1 human T46 447496 GGtLFsttPGGtRII eIF_4EBP X 2855; 9459; 2846; 4923; 5123; 3929; 7547; 45613; 39788 +Mtor mTOR Q9JLN9 mouse AKAP11 219181 E9Q777 Akap11 mouse S987 20650804 FLDFSDNsPHRSLLV X +Mtor mTOR Q9JLN9 mouse OTUD5 54644 Q3U2S4 Otud5 mouse S503 483402 AGGDRAtsPLVSLYP X X +Mtor mTOR Q9JLN9 mouse NFAT3 73181 Q8K120 Nfatc4 mouse S168 448859 QGGGAFFsPsPGSSS X +Mtor mTOR Q9JLN9 mouse TOPORS 106021 Q80Z37 Topors mouse S1016 4748993 EPSRPVPsPRTSLSS X +Mtor mTOR Q9JLN9 mouse AHNAK 66395 E9Q616 Ahnak mouse T5571 466948 APstPtGtLEFAGGD X +Mtor mTOR Q9JLN9 mouse FLNA 192176 Q8BTM8 Flna mouse S1338 3181751 VDVTYDGsPVPSSPF Filamin X +Mtor mTOR Q9JLN9 mouse MST1 58231 Q9JI11 Stk4 mouse S438 4271929 GDyEFLKsWTVEDLQ Mst1_SARAH X +Mtor mTOR Q9JLN9 mouse TBC1D10B 68449 Q8BHL3 Tbc1d10b mouse S647 3212796 GPsssLLsLPsLKSR X +Mtor mTOR Q9JLN9 mouse AKAP11 219181 E9Q777 Akap11 mouse T1092 469517 DRNVIPDtPPstPLV X +Mtor mTOR Q9JLN9 mouse NuMA-1 101706 E9Q7G0 Numa1 mouse S1973 487347 RQQRKRVssEtHQGP X +MET Met P08581 human Ron 4486 Q04912 MST1R human Y1353 456487 SALLGDHyVQLPATy X +MET Met P08581 human FIS1 51024 Q9Y3D6 FIS1 human Y38 1875830300 sKSTQFEyAWCLVRS Fis1_TPR_N X X +MET Met P08581 human IRS1 3667 P35568 IRS1 human Y612 447555 tLHtDDGyMPMsPGV X X +MET Met P08581 human FAK 5747 Q05397 PTK2 human Y925 447966 DRsNDkVyENVtGLV Focal_AT X X 3284 +MET Met P08581 human Met 4233 P08581 MET human Y1349 448472 stFIGEHyVHVNAty X 3133; 3121 +MET Met P08581 human Met 4233 P08581 MET human Y1365 448474 NVKCVAPyPsLLssE X +MET Met P08581 human IRS1 3667 P35568 IRS1 human Y896 447556 EPKsPGEyVNIEFGS X X 3070 +MET Met P08581 human FAK 5747 Q05397 PTK2 human Y577 447890 yMEDstyyKAsKGKL PK_Tyr_Ser-Thr X X 3281 +MET Met P08581 human RHOA 387 P61586 RHOA human Y42 150180312 VPTVFENyVADIEVD Ras X X +MET Met P08581 human Ron 4486 Q04912 MST1R human Y1360 456488 yVQLPATyMNLGPST X +MET Met P08581 human Ron 4486 Q04912 MST1R human Y1238 454933 RDILDREyysVQQHR PK_Tyr_Ser-Thr X +MET Met P08581 human IQGAP1 8826 P46940 IQGAP1 human Y1510 450791 LVkLQQtyAALNskA RasGAP_C X X +MET Met P08581 human FAK 5747 Q05397 PTK2 human Y407 447888 IIDEEDtytMPSTRD X X +MET Met P08581 human Met 4233 P08581 MET human Y1230 448866 FGLARDMyDkEyysV PK_Tyr_Ser-Thr X +MET Met P08581 human PARP1 142 P09874 PARP1 human Y907 53332701 MVSKSANyCHTSQGD PARP X X +MET Met P08581 human SHC1 6464 P29353 SHC1 human Y427 448511 ELFDDPsyVNVQNLD X 2431 +MET Met P08581 human Met 4233 P08581 MET human Y1356 448473 yVHVNAtyVNVKCVA X +MET Met P08581 human FAK 5747 Q05397 PTK2 human Y5 7445815 ___MAAAyLDPNLNH X X +MET Met P08581 human FAK 5747 Q05397 PTK2 human Y397 447887 sVsEtDDyAEIIDEE X X 3283; 8556 +MET Met P08581 human FAK 5747 Q05397 PTK2 human Y861 447965 PIGNQHIyQPVGKPD X X +MET Met P08581 human PBK 55872 Q96KB5 PBK human Y74 473837 NPICNDHyRsVyQkR Pkinase X X +MET Met P08581 human FAK 5747 Q05397 PTK2 human Y194 18122800 ALEKKSNyEVLEkDV FERM_M X X +MET Met P08581 human Met 4233 P08581 MET human Y1234 448470 RDMyDkEyysVHNkt PK_Tyr_Ser-Thr X X 4091; 3129; 3126; 3077; 12468; 4033; 98954 +MET Met P08581 human FAK 5747 Q05397 PTK2 human Y576 447889 RyMEDstyyKAsKGK PK_Tyr_Ser-Thr X X 3281 +MET Met P08581 human INSR 3643 P06213 INSR human Y1185 447680 FGMTRDIyEtDyyRk PK_Tyr_Ser-Thr X X 3021; 80732 +MET Met P08581 human Met 4233 P08581 MET human Y1235 448471 DMyDkEyysVHNktG PK_Tyr_Ser-Thr X X 4091; 3129; 3126; 3077; 12468; 4033; 98954 +MET Met P08581 human GSK3B 2932 P49841 GSK3B human Y56 1867735501 DRPQEVSyTDTKVIG Pkinase X X +MET Met P08581 human Ron 4486 Q04912 MST1R human Y1239 457984 DILDREyysVQQHRH PK_Tyr_Ser-Thr X +Frk FRK Q922K9 mouse FRK 14302 Q922K9 Frk mouse Y394 452029 kVDNEDIyESKHEIK PK_Tyr_Ser-Thr X +Frk FRK Q922K9 mouse NMDAR2B 14812 Q01097 Grin2b mouse Y1070 461055 IsTHtVTyGNIEGNA NMDAR2_C X 4209 +PRKACA PKACA P00517 cow CETN1 1068 Q12798 CETN1 human S170 1430241100 LRIMKKTsLY_____ X +PRKACA PKACA P00517 cow DJ-1 117287 O88767 Park7 rat S155 2566140 kDGLILtsRGPGTSF DJ-1_PfpI X +PRKACA PKACA P00517 cow CKB 24264 P07335 Ckb rat S178 2565343 GRYYALKsMTEAEQQ ATP-gua_Ptrans X +PRKACA PKACA P00517 cow ADD1 118 P35611 ADD1 human S481 451596 KEDGHRtstsAVPNL X +PRKACA PKACA P00517 cow PTHR 56813 P25961 Pth1r rat S491 452061 KRKARsGsssYsYGP X +PRKACA PKACA P00517 cow phosducin 287007 P19632 PDC cow S73 451205 ERFSRKMsVQEYELI Phosducin X +PRKACA PKACA P00517 cow PTRF 287710 P85125 Cavin1 rat T304 2566127 DKLRKsFtPDHVVyA PTRF_SDPR X +PRKACA PKACA P00517 cow smMLCK 288057 D3ZFU9 Mylk rat S1431 2565323 LATCRSTsFNVQDLL fn3 X +PRKACA PKACA P00517 cow TNNI3 P02646 TNNI3 rabbit S151 451822 LRLRVRIsADAMMQA Troponin X +PRKACA PKACA P00517 cow PDIA6 286906 Q63081 Pdia6 rat S375 2565411 kFALLKGsFSEQGIN X +PRKACA PKACA P00517 cow MRLC2 50685 P18666 Myl12b rat T19 448596 KKRPQRAtsNVFAMF X +PRKACA PKACA P00517 cow DARPP-32 360616 Q6J4I0 Ppp1r1b rat S137 448046 EEDEEEDsQAEVLKG DARPP-32 X +PRKACA PKACA P00517 cow TRPV1 83810 O35433 Trpv1 rat S820 456218 QLKHYTGsLkPEDAE X +PRKACA PKACA P00517 cow ACTG1 287876 P63259 Actg1 rat S33 2565379 APRAVFPsIVGRPRH Actin X +PRKACA PKACA P00517 cow GSBS 10842 O96001 PPP1R17 human T68 2999005 KKPRRKDtPALHIPP X +PRKACA PKACA P00517 cow GCAP2 286851 P51177 GUCA1B cow S201 455322 ISQQRRKsAMF____ X +PRKACA PKACA P00517 cow BRAF 107315883 P34908 BRAF quail S469 447803 PQRERKSsSSSEDRN X +PRKACA PKACA P00517 cow TNNI3 P02646 TNNI3 rabbit S22 448423 PAPVRRRsSANYRAY Troponin-I_N X +PRKACA PKACA P00517 cow profilin 1 18643 P62962 Pfn1 mouse T90 23135104 EFTMDLRtKstGGAP Profilin X +PRKACA PKACA P00517 cow eEF1B 363241 B5DEN5 Eef1b2 rat S106 452653 DDIDLFGsDDEEEsE EF-1_beta_acid X +PRKACA PKACA P00517 cow SIK 17691 Q60670 Sik1 mouse S577 465992 FQEGRRAsDTSLTQG X +PRKACA PKACA P00517 cow TNNI3 511094 P08057 TNNI3 cow S25 448424 PPVRRRssANYRAYA Troponin-I_N X +PRKACA PKACA P00517 cow RYR1 100009540 P11716 RYR1 rabbit S2843 451818 KKKTRKIsQTAQTYD X +PRKACA PKACA P00517 cow GLUT4 25139 P19357 Slc2a4 rat S488 451207 ATFRRtPsLLEQEVK X +PRKACA PKACA P00517 cow Tau iso5 4137 P10636-5 MAPT human S325 449104 RVQSKIGsLDNITHV Tubulin-binding X +PRKACA PKACA P00517 cow desmin 395906 P02542 DES chicken S29 466347 sPVFPRAsFGSRGsG Filament_head X +PRKACA PKACA P00517 cow FLNA 293860 C0JPT7 Flna rat S1518 2565475 YVPSREGsYSISVLY Filamin X +PRKACA PKACA P00517 cow TH 280707 P17289 TH cow S40 448545 RFVGRRQsLIQDARK TOH_N X +PRKACA PKACA P00517 cow HRas 15461 Q61411 Hras mouse S177 455374 kLNPPDEsGPGCMSC X +PRKACA PKACA P00517 cow PKAR2A 518399 P00515 PRKAR2A cow S96 458326 GRFDRRVsVCAETYN X +PRKACA PKACA P00517 cow ADD1 118 P35611 ADD1 human S59 451695 MEQkKRVsMILQsPA X +PRKACA PKACA P00517 cow NOLC1 64896 P41777 Nolc1 rat S113 455684 AAPAKRAsLPQHAGk X +PRKACA PKACA P00517 cow TH iso4 7054 P07101-4 TH human S44 448545 RFIGRRQsLIEDARK TOH_N X 2791 +PRKACA PKACA P00517 cow profilin 1 18643 P62962 Pfn1 mouse S57 14578217 VLVGkDRssFFVNGL Profilin X +PRKACA PKACA P00517 cow FETUB 83928 Q9QX79 Fetub rat S303 2565455 SITAPRGsIQHLPEQ X +PRKACA PKACA P00517 cow SNAP-25 25012 P60881 Snap25 rat T138 449875 GGFIRRVtNDARENE SNAP-25 X +PRKACA PKACA P00517 cow S6 29304 P62755 Rps6 rat S235 448092 IAKRRRLssLRAsts X 5006; 4856; 4857; 4858; 4851; 4803; 2211; 3945; 3985; 5316; 4854; 8520; 48319; 40643; 9865; 38573; 14733; 27036; 34411; 62016; 62788; 81736; 97935; 99457; 15448 +PRKACA PKACA P00517 cow MRLC1 296313 Q64122 Myl9 rat S20 1863500 KRPQSAtsNVFAMFD X 3674; 3671; 3675; 95777 +PRKACA PKACA P00517 cow Vimentin 81818 P31000 Vim rat S412 451764 EGEESRIsLPLPNFs X +PRKACA PKACA P00517 cow Tau iso8 4137 P10636-8 MAPT human S320 450139 VDLskVtskCGsLGN Tubulin-binding X +PRKACA PKACA P00517 cow smAKAP 84281 Q9BSF0 C2orf88 human S66 54468602 LEYAHRLsQDILCDA SmAKAP X +PRKACA PKACA P00517 cow SMTNL1 68678 Q99LM3 Smtnl1 mouse S301 2755200 RAPERRVsAPSRPRG X +PRKACA PKACA P00517 cow SCN2A 24766 P04775 Scn2a rat S610 451195 DNDSRRDsLFVPHRH Na_trans_cytopl X +PRKACA PKACA P00517 cow Tau iso5 4137 P10636-5 MAPT human S195 450221 PPKSGDRsGYssPGs X +PRKACA PKACA P00517 cow eEF1B 363241 B5DEN5 Eef1b2 rat S140 2566132 KPAVVAKssILLDVK X +PRKACA PKACA P00517 cow PDIA6 286906 Q63081 Pdia6 rat S88 2565407 VNADKHQsLGGQYGV Thioredoxin X +PRKACA PKACA P00517 cow NDUFS3 295923 D3ZG43 Ndufs3 rat S59 2565331 DVTHkRLsAFGEYVA X +PRKACA PKACA P00517 cow TRPV1 83810 O35433 Trpv1 rat S116 454886 PRLYDRRsIFDAVAQ X X +PRKACA PKACA P00517 cow HSP27 24471 P42930 Hspb1 rat S86 448403 RALNRQLssGVsEIR X 2406; 2401; 9709; 11892; 64293 +PRKACA PKACA P00517 cow GSBS 10842 O96001 PPP1R17 human T119 2999004 kKPRRKDtPALHMSP X +PRKACA PKACA P00517 cow Zyxin 114636 Q99MM3 Zyx rat S144 460645 QPREKVssIDLEIDS X 4863; 8467 +PRKACA PKACA P00517 cow desmin 395906 P02542 DES chicken S35 466350 AsFGSRGsGSsVTSR Filament_head X +PRKACA PKACA P00517 cow Tau iso5 4137 P10636-5 MAPT human S262 447930 NVKSKIGsTENLKHQ Tubulin-binding X +PRKACA PKACA P00517 cow NMDAR1 24408 P35439 Grin1 rat S897 448256 sFKRRRssKDtSTGG X +PRKACA PKACA P00517 cow H2B 615043 P62808 H2BC19 cow S32 447801 DGKKRKRsRKEsYSV Histone X +PRKACA PKACA P00517 cow SDPR 316384 Q66H98 Cavin2 rat S332 4732711 GsFTEGLsEAsLPSG X +PRKACA PKACA P00517 cow PTRF 287710 P85125 Cavin1 rat S368 452129 TDLLRGssPDVHTLL X +PRKACA PKACA P00517 cow Tau iso5 4137 P10636-5 MAPT human T231 449079 KKVAVVRtPPKsPSS X 20473; 71429 +PRKACA PKACA P00517 cow TNNI3 P02646 TNNI3 rabbit T143 451483 RGKFKRPtLRLRVRI Troponin X +PRKACA PKACA P00517 cow PGM5 679990 D3ZVR9 Pgm5 rat T31 2565495 GGGLRRPtGLFEGQR PGM_PMM_I X +PRKACA PKACA P00517 cow Serpina3g 24794 P05545 Serpina3k rat S313 2565339 ELRMPKFsISTDYNL Serpin X +PRKACA PKACA P00517 cow CRYBB2 287011 P02522 CRYBB2 cow S204 451609 QRGAFHPsS______ X +PRKACA PKACA P00517 cow GANAB 293721 D3ZAN3 Ganab rat S769 2565327 GSPESRLsFQHDPET X +PRKACA PKACA P00517 cow profilin 1 18643 P62962 Pfn1 mouse T93 15405470 MDLRtKstGGAPTFN Profilin X +PRKACA PKACA P00517 cow AHNAK 191572 A0A0G2JUA5 Ahnak rat S5038 452760 EGPKVRGsLGATGEL X +PRKACA PKACA P00517 cow GFAP 396562 F1RR02 GFAP pig S8 449618 MERRRVtsAARRsYV Filament_head X +PRKACA PKACA P00517 cow TPH2 121278 Q8IWU9 TPH2 human S19 470085 YWARRGFsLDSAVPE X +PRKACA PKACA P00517 cow MYPT1 116670 Q10728 Ppp1r12a rat S854 451999 RPREKRRstGVSFWT X +PRKACA PKACA P00517 cow GBF1 309451 F1M8X9 Gbf1 rat S174 2565467 ICFEMRLsELLRKSA DCB X +PRKACA PKACA P00517 cow BAD 12015 Q61337 Bad mouse S112 447860 ETRsRHssyPAGtEE Bcl-2_BAD X 9291; 5284; 9296; 5193; 11865; 94223 +PRKACA PKACA P00517 cow 14-3-3 eta 22629 P68510 Ywhah mouse S59 450482 VVGARRSsWRVIssI 14-3-3 X 52631 +PRKACA PKACA P00517 cow HSP27 24471 P42930 Hspb1 rat S15 448401 FsLLRsPsWEPFRDW X +PRKACA PKACA P00517 cow DMN 308709 Q810D0 Synm rat S777 2565443 EVDDVsPsPKGFIEE X +PRKACA PKACA P00517 cow Tau iso5 4137 P10636-5 MAPT human S198 449551 SGDRsGYssPGsPGt X +PRKACA PKACA P00517 cow HSP90A 299331 P82995 Hsp90aa1 rat S211 2565447 kEIVkKHsQFIGYPI HSP90 X +PRKACA PKACA P00517 cow PTHR 56813 P25961 Pth1r rat S473 452059 VQAEIRKsWsRWTLA X +PRKACA PKACA P00517 cow SCN2A 24766 P04775 Scn2a rat S573 451193 LFsPrRNsRAsLFNF Na_trans_cytopl X +PRKACA PKACA P00517 cow ADD2 119 P35612 ADD2 human T55 451694 MEQKKRVtMILQsPs X +PRKACA PKACA P00517 cow ATP5J 94271 P21571 Atp5pf rat S57 2565359 YkAKRLAsGGPVDTG ATP-synt_F6 X +PRKACA PKACA P00517 cow BRAF 107315883 P34908 BRAF quail S486 447804 KTLGRRDsSDDWEIP X +PRKACA PKACA P00517 cow TRPV1 83810 O35433 Trpv1 rat T144 456216 QRSKKRLtDSEFKDP Ank_2 X +PRKACA PKACA P00517 cow LPP 288010 Q5XI07 Lpp rat S117 460573 TLEERRssLDAEIDS X +PRKACA PKACA P00517 cow MRLC1 296313 Q64122 Myl9 rat T19 1863501 KKRPQSAtsNVFAMF X 3674; 95777 +PRKACA PKACA P00517 cow FLNA 293860 C0JPT7 Flna rat T2328 471891 SGDARRLtVSSLQES Filamin X +PRKACA PKACA P00517 cow PEDF 287526 Q80ZA3 Serpinf1 rat T227 455233 KFDSRKttLQDFHLD Serpin X +PRKACA PKACA P00517 cow coronin 1C 501841 NP_001102797 Coro1c rat S354 2565335 IMTVPRKsDLFQDDL WD40_4 X +PRKACA PKACA P00517 cow ANXA1 25380 P07150 Anxa1 rat T216 447973 AGERRKGtDVNVFNT Annexin X +PRKACA PKACA P00517 cow Merlin 4771 P35240 NF2 human S518 448282 DTDMKRLsMEIEKEK ERM_C X 9163; 13281 +PRKACA PKACA P00517 cow FLNA 293860 C0JPT7 Flna rat S2144 451357 TRRRRAPsVANVGsH Filamin X 4761 +PRKACA PKACA P00517 cow MCAM 78967 Q9EPF2 Mcam rat S95 2566136 GEYEHRLsLHGPGAT V-set X +PRKACA PKACA P00517 cow STMN1 3925 P16949 STMN1 human S16 448554 kELEKrAsGQAFELI Stathmin X 3353 +PRKACA PKACA P00517 cow GABRB1 14400 P50571 Gabrb1 mouse S434 450244 GRIRRRAsQLKVKIP Neur_chan_memb X +PRKACA PKACA P00517 cow hnRNP A1 3178 P09651 HNRNPA1 human S199 451555 sQrGrsGsGNFGGGr X +PRKACA PKACA P00517 cow FLNA 293860 C0JPT7 Flna rat S2515 448843 VTGPRLVsNHSLHET X +PRKACA PKACA P00517 cow CGB 1082 P0DN86 CGB3 human T117 451336 CALCRRStTDCGGPK Cys_knot X +PRKACA PKACA P00517 cow DJ-1 117287 O88767 Park7 rat T154 2566111 EkDGLILtsRGPGTS DJ-1_PfpI X +PRKACA PKACA P00517 cow TNNI3 21954 P48787 Tnni3 mouse S24 448424 APVRRRssANyRAYA Troponin-I_N X +PRKACA PKACA P00517 cow CP 24268 P13635 Cp rat T668 2565351 SKGERRDtANLFPHK X +PRKACA PKACA P00517 cow GJB1 29584 P08033 Gjb1 rat S233 451163 NPPSRKGsGFGHRLs X X +PRKACA PKACA P00517 cow PDE5A 8654 O76074 PDE5A human S102 448178 GTPTRKIsAsEFDRP X +PRKACA PKACA P00517 cow Calnexin 29144 P35565 Canx rat S582 449100 EDEILNRsPRNRKPR X +PRKACA PKACA P00517 cow RPN1 25596 P07153 Rpn1 rat S65 2566144 GGSTARAssFVLALE Ribophorin_I X +PRKACA PKACA P00517 cow VASP 7408 P50552 VASP human S239 448380 GAKLRKVsKQEEASG X 3114; 37565 +PRKACA PKACA P00517 cow ACTA1 29437 P68136 Acta1 rat S35 2565387 APRAVFPsIVGRPRH Actin X +PRKACA PKACA P00517 cow MARCKS 4082 P29966 MARCKS human S159 447786 kkKKKRFsFkKsFkL MARCKS X 2741; 11992 +PRKACA PKACA P00517 cow BAD 12015 Q61337 Bad mouse S155 447863 GRELRRMsDEFEGsF Bcl-2_BAD X 9297 +PRKACA PKACA P00517 cow desmin 64362 P48675 Des rat S81 460578 LGTTRAPsYGAGELL Filament_head X +PRKACA PKACA P00517 cow HSP90A 299331 P82995 Hsp90aa1 rat S263 448662 PEIEDVGsDEEEEEK HSP90 X +PRKACA PKACA P00517 cow DARPP-32 282459 P07516 PPP1R1B cow T34 448047 MIRRRRPtPAMLFRL DARPP-32 X 12438 +PRKACA PKACA P00517 cow RPN1 25596 P07153 Rpn1 rat S66 2566115 GSTARAssFVLALEP Ribophorin_I X +PRKACA PKACA P00517 cow AHNAK 191572 A0A0G2JUA5 Ahnak rat T159 2565491 ITVTRRVtAYTVDVT X +PRKACA PKACA P00517 cow PDE6G 281977 P04972 PDE6G cow T35 450149 PKFKQRQtRQFKSKP PDE6_gamma X +PRKACA PKACA P00517 cow desmin 395906 P02542 DES chicken S50 449614 VYQVSRTsAVPTLsT Filament_head X +PRKACA PKACA P00517 cow TNNI3 511094 P08057 TNNI3 cow S24 448423 PPPVRRRssANYRAY Troponin-I_N X +PRKACA PKACA P00517 cow TNNI3 P02646 TNNI3 rabbit S77 451839 GEKGRALsTRCQPLE Troponin X +PRKACA PKACA P00517 cow CACNB2 116600 Q8VGC3 Cacnb2 rat S529 1868239900 KKSQHRSssATHQNH X +PRKACA PKACA P00517 cow TRPV1 83810 O35433 Trpv1 rat S502 450016 YFLQRRPsLKSLFVD Ion_trans X +PRKACA PKACA P00517 cow GPIbB 2812 P13224 GP1BB human S191 456005 ARAAARLsLtDPLVA X +PRKACA PKACA P00517 cow TRPV1 83810 O35433 Trpv1 rat S774 456217 EGVKRTLsFSLRSGR X +PRKACA PKACA P00517 cow FLNC 362332 D3ZHA0 Flnc rat T2413 2565483 SDDARRLtVTSLQET Filamin X +PRKACA PKACA P00517 cow PFKM 100345647 P00511 PFKM rabbit S775 458322 EHISRKRsGEATV__ X +PRKACA PKACA P00517 cow PFKFB2 287019 P26285 PFKFB2 cow S484 452046 IRRPRNYsVGSRPLQ X +PRKACA PKACA P00517 cow CAMKK2 83506 O88831 Camkk2 rat T144 15425433 PRMPRRPtVESHHVS X +PRKACA PKACA P00517 cow FKBP9 297123 Q66H94 Fkbp9 rat S277 2565419 SCERRSQsGDFLRYH FKBP_C X +PRKACA PKACA P00517 cow ACTA1 29437 P68136 Acta1 rat S201 2565391 ILTERGysFVTtAER Actin X +PRKACA PKACA P00517 cow Destrin 502674 Q7M0E3 Dstn rat S147 2565439 PEDLNRTsIAEKLGG Cofilin_ADF X +PRKACA PKACA P00517 cow HSP27 24471 P42930 Hspb1 rat S102 2565371 TADRWRVsLDVNHFA HSP20 X +PRKACA PKACA P00517 cow MYBPC3 17868 O70468 Mybpc3 mouse S282 471080 AGAGRRtsDsHEDAG X +PRKACA PKACA P00517 cow Tau iso5 4137 P10636-5 MAPT human T205 447933 ssPGsPGtPGSRSRT X 25377; 43964; 53001; 49561; 20060; 33032; 30505; 20739; 98160 +PRKACA PKACA P00517 cow FLNA 293860 C0JPT7 Flna rat S343 2565471 NDKNRTFsVWYVPEV Filamin X +PRKACA PKACA P00517 cow CETN2 1069 P41208 CETN2 human S170 448199 LRIMkKTsLY_____ X X +PRKACA PKACA P00517 cow eEF1B 363241 B5DEN5 Eef1b2 rat S141 476101 PAVVAKssILLDVKP EF1_GNE X +PRKACA PKACA P00517 cow PTRF 287710 P85125 Cavin1 rat S302 465873 SRDKLRKsFtPDHVV PTRF_SDPR X +PRKACA PKACA P00517 cow A-albumin 282708 P36953 Afm rat T363 2565367 YDYSRRHtELSTPEL Serum_albumin X +PRKACA PKACA P00517 cow MYPT1 116670 Q10728 Ppp1r12a rat S696 451998 QARQSRRstQGVTLT X +PRKACA PKACA P00517 cow GFAP 396562 F1RR02 GFAP pig S34 449621 LGPGPRLsLARMPPP Filament_head X +PRKACA PKACA P00517 cow TRPV1 83810 O35433 Trpv1 rat T370 455383 RHLSRKFtEWAYGPV X X +PRKACA PKACA P00517 cow RIL 24915 P36202 Pdlim4 rat S119 468635 PATsRRssIsGIsLE X +PRKACA PKACA P00517 cow RAF1 5894 P04049 RAF1 human S43 447744 FGyQRRAsDDGKLtD X +PRKACA PKACA P00517 cow ACTN1 81634 Q9Z1P2 Actn1 rat S404 2565463 EkFRQKAsIHEAWTD Spectrin X +PRKACA PKACA P00517 cow S6 29304 P62755 Rps6 rat S240 448094 RLssLRAstsKsESs X 2215; 5364; 5018; 93315; 5044; 13020; 14236; 9468; 35708; 88441; 34918 +PRKACA PKACA P00517 cow PDE10A iso2 10846 Q9Y233-2 PDE10A human T16 478273 AScFRRLtECFLSPS X +PRKACA PKACA P00517 cow ATF-2 1386 P15336 ATF2 human S62 451440 FGPARNDsVIVADQt X +PRKACA PKACA P00517 cow H1C 513971 P02253 H1-2 cow S36 450120 AGARRKAsGPPVSEL X +PRKACA PKACA P00517 cow NOLC1 64896 P41777 Nolc1 rat S628 455686 KGEKRAssPFRRVRE X +PRKACA PKACA P00517 cow Zyxin 114636 Q99MM3 Zyx rat S143 460644 PQPREKVssIDLEID X 4863; 8467 +PRKACA PKACA P00517 cow phosducin 25343 P20942 Pdc rat S73 451205 ERMSRKMsIQEYELI Phosducin X +PRKACA PKACA P00517 cow MYPT1 116670 Q10728 Ppp1r12a rat T855 452075 PREKRRstGVSFWTQ X 4563 +PRKACA PKACA P00517 cow RCN3 494125 I6L9G5 Rcn3 rat S117 2565399 QQRHIRDsVSAAWHT X +PRKACA PKACA P00517 cow MCAM 78967 Q9EPF2 Mcam rat S85 2566107 VHQGKGQsEPGEYEH V-set X +PRKACA PKACA P00517 cow Oct7 18992 P31360 Pou3f2 mouse S362 486486 RKRKKRtsIEVSVKG Homeodomain X +PRKACA PKACA P00517 cow AQP0 280859 P06624 MIP cow S243 451790 ILKGSRPsEsNGQPE X +PRKACA PKACA P00517 cow PFKFB1 24638 P07953 Pfkfb1 rat S33 456206 VLQRRRGsSIPQFTN 6PF2K X +PRKACA PKACA P00517 cow CFTR 1080 P13569 CFTR human S660 449979 FSAERRNsILTETLH CFTR_R X X +PRKACA PKACA P00517 cow CACNB2 116600 Q8VGC3 Cacnb2 rat S530 451474 KSQHRSssATHQNHR X +PRKACA PKACA P00517 cow TPH2 121278 Q8IWU9 TPH2 human S104 1033700 RKSRRRSsEVEIFVD X +PRKACA PKACA P00517 cow ATP1A1 24211 P06685 Atp1a1 rat S943 451649 ICKTRRNsVFQQGMK Cation_ATPase_C X +PRKACA PKACA P00517 cow Oct7 5454 P20265 POU3F2 human S360 486486 RKRKKRTsIEVSVKG Homeodomain X +PRKACA PKACA P00517 cow Tau iso5 4137 P10636-5 MAPT human S373 449082 PVVsGDTsPRHLSNV X 35834; 20194; 98523; 91600; 49562 +PRKACA PKACA P00517 cow AHNAK 191572 A0A0G2JUA5 Ahnak rat S136 2565487 KIKPRLRsEDGVEGD X +PRKACA PKACA P00517 cow MCAM 78967 Q9EPF2 Mcam rat S426 2565319 LNRTRRVsVGIFGSP X +PRKACA PKACA P00517 cow PSEN1 5663 P49768 PSEN1 human S310 452183 PEAQRRVsKNskyNA Presenilin X +PRKACA PKACA P00517 cow FLNA 2316 P21333 FLNA human S2152 451357 tRRRRAPsVANVGsH Filamin X 4761 +PRKACA PKACA P00517 cow TNNI3 21954 P48787 Tnni3 mouse S23 448423 PAPVRRRssANyRAY Troponin-I_N X +PRKACA PKACA P00517 cow ADD2 119 P35612 ADD2 human S713 449802 KKKFRtPsFLKKsKK X +PRKACA PKACA P00517 cow TH iso2 7054 P07101-2 TH human S67 448545 RFIGRRQsLIEDARK TOH_N X 2791 +PRKACA PKACA P00517 cow ADD1 118 P35611 ADD1 human S726 449829 KKKFRtPsFLKKsKK X +PRKACA PKACA P00517 cow MYBPC3 17868 O70468 Mybpc3 mouse S302 471081 sLLKKRDsFRRDskL X +PRKACA PKACA P00517 cow S6 29304 P62755 Rps6 rat S236 448093 AKRRRLssLRAstsK X 5006; 4856; 4857; 4858; 4851; 4803; 2211; 3945; 3985; 5316; 4854; 8520; 48319; 40643; 9865; 38573; 14733; 27036; 34411; 62016; 62788; 81736; 97935; 99457; 15448 +PRKACA PKACA P00517 cow ACTG2 25365 P63269 Actg2 rat S200 2565800 ILTERGysFVTtAER Actin X +PRKACA PKACA P00517 cow SCN2A 24766 P04775 Scn2a rat S687 451194 EIRKRRsssyHVsMD Na_trans_cytopl X +PRKACA PKACA P00517 cow ITIH4 54404 Q5EBC0 Itih4 rat S225 2565395 TLSQQRKsQNEQDTV X +PRKACA PKACA P00517 cow FLNA 293860 C0JPT7 Flna rat S2607 2565479 HMGSRLYsVSYLLKD Filamin X +PRKACA PKACA P00517 cow PEDF 287526 Q80ZA3 Serpinf1 rat T226 2566122 TKFDSRKttLQDFHL Serpin X +PRKACA PKACA P00517 cow ETV1 2115 P50549 ETV1 human S334 3059601 PTYQRRGsLQLWQFL X +PRKACA PKACA P00517 cow eNOS 287024 P29473 NOS3 cow S1179 447884 TSRIRtQsFsLQERH X 9570 +PRKACA PKACA P00517 cow PTHR 56813 P25961 Pth1r rat S475 452060 AEIRKsWsRWTLALD X +PRKACA PKACA P00517 cow ADD1 118 P35611 ADD1 human S408 451594 REKSKkYsDVEVPAS X +PRKACA PKACA P00517 cow MYH11 24582 E9PTU4 Myh11 rat T1763 2565415 sDRVRKAtLQAEQLS Myosin_tail_1 X +PRKACA PKACA P00517 cow MYPT1 116670 Q10728 Ppp1r12a rat T697 448587 ARQSRRstQGVTLTD X 5163 +PRKACA PKACA P00517 cow SERPINA1 24648 P17475 Serpina1 rat S45 2565355 SPTYRKIsSNLADFA X +PRKACA PKACA P00517 cow Tau iso5 4137 P10636-5 MAPT human S202 447928 sGYssPGsPGtPGSR X 39357; 30505 +PRKACA PKACA P00517 cow TH 7054 P07101 TH human S71 448545 RFIGRRQsLIEDARK TOH_N X 2791 +PRKACA PKACA P00517 cow GFAP 396562 F1RR02 GFAP pig T7 449617 _MERRRVtsAARRsY Filament_head X +PRKACA PKACA P00517 cow HSP27 24471 P42930 Hspb1 rat T147 471871 RCFTRKYtLPPGVDP HSP20 X +PRKACA PKACA P00517 cow CDKN2D 1032 P55273 CDKN2D human T141 25256101 RRDARGLtPLELALQ Ank_2 X +PRKACA PKACA P00517 cow GLUD1 24399 P10860 Glud1 rat T206 2565347 EkITRRFtMELAkkG ELFV_dehydrog_N X +PRKACA PKACA P00517 cow SDPR 316384 Q66H98 Cavin2 rat S51 2565423 EEAIRDNsQVNAVTV X +PRKACA PKACA P00517 cow TRPV1 83810 O35433 Trpv1 rat S6 456215 __MEQRAsLDSEESE X +PRKACA PKACA P00517 cow Oct1 5451 P14859 POU2F1 human S385 456220 RRRKKRTsIETNIRV Homeodomain X +PRKACA PKACA P00517 cow GFAP 396562 F1RR02 GFAP pig S13 449619 VtsAARRsYVSSLET Filament_head X +PRKACA PKACA P00517 cow CFTR 1080 P13569 CFTR human S700 449978 FGEKRkNsILNPINs CFTR_R X X +PRKACA PKACA P00517 cow CACNA1S 100009585 P07293 CACNA1S rabbit S1617 452133 TFLERTNsLPPVMAN X +PRKACA PKACA P00517 cow NOLC1 64896 P41777 Nolc1 rat S627 455685 KKGEKRAssPFRRVR X +PRKACA PKACA P00517 cow CAMKK1 60341 P97756 Camkk1 rat T108 452083 PRAWRRPtIESHHVA X +PRKACA PKACA P00517 cow ACTG2 25365 P63269 Actg2 rat S34 2565383 APRAVFPsIVGRPRH Actin X +PRKACA PKACA P00517 cow LRPAP1 116565 Q99068 Lrpap1 rat S245 2565451 LDRLRKVsHQGYGPA Alpha-2-MRAP_C X +PRKACA PKACA P00517 cow PFKFB2 287019 P26285 PFKFB2 cow S467 448460 PVRMRRNsFTPLSSS X +PRKACA PKACA P00517 cow Tau iso5 4137 P10636-5 MAPT human S199 447927 GDRsGYssPGsPGtP X 29957 +PRKACA PKACA P00517 cow FGFBP1 281812 Q9MZ06 FGFBP1 cow S36 487543 NRRGSKAsADESLAL FGF-BP1 X +PRKACA PKACA P00517 cow H2B 615043 P62808 H2BC19 cow S36 449903 RKRsRKEsYSVYVYK Histone X +PRKACA PKACA P00517 cow BAD 12015 Q61337 Bad mouse S136 447862 PFRGRsRsAPPNLWA Bcl-2_BAD X 9295; 5286; 4366 +PRKACA PKACA P00517 cow Tau iso5 4137 P10636-5 MAPT human S235 449080 VVRtPPKsPSSAKSR X 20473 +PRKACA PKACA P00517 cow GSTP1 2950 P09211 GSTP1 human S185 455118 SAYVGRLsARPkLkA GST_C_3 X +PRKACA PKACA P00517 cow ADD1 118 P35611 ADD1 human S436 451595 tCsPLRHsFQkQQRE X +PRKACA PKACA P00517 cow PTRF 287710 P85125 Cavin1 rat S367 452128 ETDLLRGssPDVHTL X +PRKACA PKACA P00517 cow smMLCK 288057 D3ZFU9 Mylk rat S1819 468781 GRKSsTGsPTsPINA X +PRKACA PKACA P00517 cow PFKM 100345647 P00511 PFKM rabbit S377 4707523 AMKLRGRsFMNNWEV X +PRKACA PKACA P00517 cow DARPP-32 360616 Q6J4I0 Ppp1r1b rat T34 448047 MIRRRRPtPALLFRV DARPP-32 X 12438 +PRKACA PKACA P00517 cow profilin 1 18643 P62962 Pfn1 mouse S92 31868255 TMDLRtKstGGAPTF Profilin X +PRKACA PKACA P00517 cow CACNA1S 100009585 P07293 CACNA1S rabbit S687 452132 ERKRRKMsRGLPDKT X +PRKACA PKACA P00517 cow VASP 7408 P50552 VASP human S157 448379 EHIERRVsNAGGPPA X 3111; 84519 +PRKACA PKACA P00517 cow COL4A3 1285 Q01955 COL4A3 human S1452 1264400 GFVFTRHsQTTAIPS C4 X +PRKACA PKACA P00517 cow COL4A3 1285 Q01955 COL4A3 human S1435 1247500 LKGKRGDsGSPATWT Collagen X +PRKACA PKACA P00517 cow MYBPC3 17868 O70468 Mybpc3 mouse S273 471079 RsAFRRtsLAGAGRR X +PRKACA PKACA P00517 cow Oct7 18992 P31360 Pou3f2 mouse T361 22996304 GRKRKKRtsIEVSVK Homeodomain X +PRKACA PKACA P00517 cow NETO2 307757 C6K2K4 Neto2 rat S409 4752528 SLREKEIsADLADLS X +PRKACA PKACA P00517 cow TH iso3 7054 P07101-3 TH human S40 448545 RFIGRRQsLIEDARK TOH_N X 2791 +PRKACA PKACA P00517 cow ACTB 81822 P60711 Actb rat S33 2565375 APRAVFPsIVGRPRH Actin X +PRKACA PKACA P00517 cow ALDOA 24189 P05065 Aldoa rat S46 477796 sIAkRLQsIGTENTE Glycolytic X +PRKACA PKACA P00517 cow PKACA 25636 P27791 Prkaca rat T198 448459 RVKGRtWtLCGTPEY Pkinase X 4781; 5661 +PRKACA PKACA P00517 cow EEF1G 293725 Q68FR6 Eef1g rat S298 2565435 DEFkRKYsNEDTLSV EF1G X +PRKACA PKACA P00517 cow CACNB2 116600 Q8VGC3 Cacnb2 rat S510 451397 RSAPRSAsQAEEEPC X +PRKACA PKACA P00517 cow RYR2 6262 Q92736 RYR2 human S2808 448848 YNRTRRIsQTSQVsV X +PRKACA PKACA P00517 cow RCN2 29218 Q62703 Rcn2 rat S71 2565403 EQQRRLQsIIkKIDS EF-hand_5 X +PRKACA PKACA P00517 cow ACTN4 63836 Q9QXQ0 Actn4 rat S423 2565459 EkFRQKAsIHEAWTD Spectrin X +PRKACA PKACA P00517 cow HSP90B 301252 P34058 Hsp90ab1 rat S452 2565363 stNRRRLsELLRYHT HSP90 X +PRKACA PKACA P00517 cow MRLC2 50685 P18666 Myl12b rat S20 448595 KRPQRAtsNVFAMFD X +PRKACA PKACA P00517 cow RIL 24915 P36202 Pdlim4 rat S118 481133 sPATsRRssIsGIsL X +PMVK PMVK Q15126 human CTNNB1 1499 P35222 CTNNB1 human S184 1881579404 QLskKEAsRHAIMRs X X + Pyk2 no information Cortactin 2017 Q14247 CTTN human Y421 447702 rLPssPVyEDAAsFK X 4569 +Mapk3 ERK1 Q7M0H9 hamster GRB10 2887 Q13322 GRB10 human S476 455870 MNILGsQsPLHPSTL X 11817 +Mapk3 ERK1 Q7M0H9 hamster GRB10 2887 Q13322 GRB10 human S150 454185 PELCGPGsPPVLtPG X +Ptk2 FAK O35346 rat P130Cas 25414 Q63767 Bcar1 rat Y762 448399 EGGWMEDyDyVHLQG CAS_C X X +Ptk2 FAK O35346 rat FAK 25614 O35346 Ptk2 rat Y397 447887 SVSETDDyAEIIDEE X X 3283; 8556 +Ptk2 FAK O35346 rat P130Cas 25414 Q63767 Bcar1 rat Y263 448722 PSPATDLyQVPPGPG X X 4015 +Ptk2 FAK O35346 rat P130Cas 25414 Q63767 Bcar1 rat Y764 448400 GWMEDyDyVHLQGKE CAS_C X X +Src Src Q9WUD9 rat PDK1 81745 O55173 Pdpk1 rat Y379 447695 DEDCyGNyDNLLSQF X +Src Src Q9WUD9 rat GJA1 2697 P17302 GJA1 human Y265 447815 kDCGsQkyAyFNGCs X +Src Src Q9WUD9 rat CACNA1C 24239 P22002 Cacna1c rat Y1787 880751701 STFTPSSySSTGSNA CAC1F_C X +Src Src Q9WUD9 rat PKCD 170538 P09215 Prkcd rat Y311 447573 TPETVGIyQGFEKKT X X 2055 +Src Src Q9WUD9 rat SYN1 24949 P09951 Syn1 rat Y301 478277 VVALTkTyATAEPFI Synapsin_C X +Src Src Q9WUD9 rat PDK1 81745 O55173 Pdpk1 rat Y9 447696 ARTTSQLyDAVPIQS X +Src Src Q9WUD9 rat GJA1 24392 P08050 Gja1 rat Y265 447815 kDCGsPkyAyFNGCS X X +Src Src Q9WUD9 rat DYN2 25751 P39052 Dnm2 rat Y597 451200 NTEQRNVykDLRQIE PH X +Src Src Q9WUD9 rat GIT1 83709 Q9Z272 Git1 rat Y554 448965 ELEDDAIySVHVPAG X +Src Src Q9WUD9 rat DYN1 140694 P21575 Dnm1 rat Y597 447606 NTEQRNVykDYRQLE PH X +Src Src Q9WUD9 rat PAG 64019 Q9JM80 Pag1 rat Y314 450659 EEEISAMysSVNKPG PAG X X +Src Src Q9WUD9 rat Kv7.3 iso2 29682 O88944-2 Kcnq3 rat Y67 453408 VKRNNAKyRRIQTLI X +Src Src Q9WUD9 rat GIT1 83709 Q9Z272 Git1 rat Y293 15702201 EELAMDVyDEVDRRE GIT_SHD X +Src Src Q9WUD9 rat PAG 94212 Q3U1F9 Pag1 mouse Y314 450659 EEEISAMySSVNKPG PAG X +Src Src Q9WUD9 rat Src 6714 P12931 SRC human Y530 448235 FTstEPQyQPGENL_ X 2105 +Src Src Q9WUD9 rat DYN2 25751 P39052 Dnm2 rat Y231 451199 LLPLRRGyIGVVNRS Dynamin_M X +Src Src Q9WUD9 rat CACNA1C 24239 P22002 Cacna1c rat Y1738 880751700 LFGNHVSyYQSDSRS CAC1F_C X +Src Src Q9WUD9 rat EGFR 13649 Q01279 Egfr mouse Y871 448061 LGAEEkEyHAEGGkV PK_Tyr_Ser-Thr X 2231; 6963 +Src Src Q9WUD9 rat NMDAR2B 24410 Q00960 Grin2b rat Y1336 448166 RFMDGsPyAHMFEMP NMDAR2_C X +Src Src Q9WUD9 rat APBA1 319924 B2RUJ5 Apba1 mouse Y187 15402159 HRAEDEPyAEPyADY X +Src Src Q9WUD9 rat DYN1 140694 P21575 Dnm1 rat Y231 447605 LLPLRRGyIGVVNRS Dynamin_M X +Src Src Q9WUD9 rat SMAD1 25671 P97588 Smad1 rat S468 448363 HNPISsVs_______ X 9516; 9576; 12428; 11971; 67959; 13820; 85553; 52937 +Src Src Q9WUD9 rat PKCD 170538 P09215 Prkcd rat Y332 450077 IPDNNGTyGKIWEGS X +Src Src Q9WUD9 rat APBA1 319924 B2RUJ5 Apba1 mouse Y191 54165900 DEPyAEPyADYGGLQ X +Src Src Q9WUD9 rat APBA1 319924 B2RUJ5 Apba1 mouse Y202 23082644 GGLQEHVyEEIGDAP X X +Src Src Q9WUD9 rat PDK1 81745 O55173 Pdpk1 rat Y376 447694 SEDDEDCyGNyDNLL X +Src Src Q9WUD9 rat TACE 57027 Q9Z1K9 Adam17 rat Y702 28706300 DKKLDKQyESLSLFH X +Src Src Q9WUD9 rat GABRG2 29709 Q6PW52 Gabrg2 rat Y411 455817 LQERDEEyGyECLDG Neur_chan_memb X +Src Src Q9WUD9 rat P130Cas 25414 Q63767 Bcar1 rat Y508 448720 SVIDDGVyAVPPPAE X 4011 +Src Src Q9WUD9 rat Src 83805 Q9WUD9 Src rat Y530 448235 FTSTEPQyQPGENL_ X 2105 +Src Src Q9WUD9 rat NMDAR2B 24410 Q00960 Grin2b rat Y1472 448167 GSSNGHVyEKLssIE NMDAR2_C X 4208 +Src Src Q9WUD9 rat TACE 11491 Q9Z0F8 Adam17 mouse Y702 28706300 DKKLDKQyESLSLFH X +Src Src Q9WUD9 rat PANX1 315435 P60570 Panx1 rat Y308 54421200 KtDVLKVyEILPTFD X +Src Src Q9WUD9 rat SPTAN1 64159 P16086 Sptan1 rat Y1176 448817 AVQQQEVyGMMPRDE X +Src Src Q9WUD9 rat Kv7.3 iso2 29682 O88944-2 Kcnq3 rat Y349 453409 IQAAWRYyATNPNRL X +Src Src Q9WUD9 rat caveolin-1 25404 P41350 Cav1 rat Y14 448422 VDsEGHLyTVPIREQ X 3251 +Src Src Q9WUD9 rat GluR2 29627 P19491 Gria2 rat Y876 452173 ykEGyNVyGIEsVkI X 4027; 3921 +Src Src Q9WUD9 rat FAK 25614 O35346 Ptk2 rat Y928 447966 DRSNDKVyENVTGLV Focal_AT X 3284 +Src Src Q9WUD9 rat EGFR 24329 Q9QX70 Egfr rat Y870 448061 LGAEEKEyHAEGGKV PK_Tyr_Ser-Thr X 2231; 6963 +Src Src Q9WUD9 rat G-alpha t1 281794 P04695 GNAT1 cow Y142 470102 CFDRASEyQLNDSAG G-alpha X +Src Src Q9WUD9 rat GABRG2 29709 Q6PW52 Gabrg2 rat Y413 455818 ERDEEyGyECLDGKD Neur_chan_memb X +Rock1 ROCK1 Q63644 rat TSC2 24855 P49816 Tsc2 rat T1203 19075303 EILVRRPtGNTSWLM X +Rock1 ROCK1 Q63644 rat IRS1 25467 P35570 Irs1 rat S635 447507 yMPMsPKsVsAPQQI X 2388 +Rock1 ROCK1 Q63644 rat IRS1 16367 P35569 Irs1 mouse S302 450190 TRRSRtEsITAtsPA X 2384; 2491 +Rock1 ROCK1 Q63644 rat IRS1 16367 P35569 Irs1 mouse S635 447507 yMPMsPKsVsAPQQI X 2388 +Rock1 ROCK1 Q63644 rat IRS1 25467 P35570 Irs1 rat S302 450190 TRRSRTEsITATsPA X 2384; 2491 +Rock1 ROCK1 Q63644 rat LIMK2 29524 P53670 Limk2 rat T505 448683 SDRKKRYtVVGNPYW PK_Tyr_Ser-Thr X 3841 +Rock1 ROCK1 Q63644 rat IRS1 16367 P35569 Irs1 mouse S632 447506 NGDyMPMsPKsVsAP X 2388 +Rock1 ROCK1 Q63644 rat IRS1 25467 P35570 Irs1 rat S632 447506 NGDyMPMsPKsVsAP X 2388 +Rock1 ROCK1 Q63644 rat MYPT1 116670 Q10728 Ppp1r12a rat T855 452075 PREKRRstGVSFWTQ X 4563 +Rock1 ROCK1 Q63644 rat MYPT1 116670 Q10728 Ppp1r12a rat T697 448587 ARQSRRstQGVTLTD X X 5163 +DYRK1A DYRK1A Q13627 human Tau iso8 4137 P10636-8 MAPT human S199 447927 GDRsGyssPGsPGtP X X 29957 +DYRK1A DYRK1A Q13627 human RCAN1 54720 Q9JHG6 Rcan1 mouse T246 21511701 QTRRPEYtPIHLS__ X +DYRK1A DYRK1A Q13627 human Tau iso8 4137 P10636-8 MAPT human S396 449081 GAEIVyKsPVVsGDt X X 9632 +DYRK1A DYRK1A Q13627 human Tau iso8 4137 P10636-8 MAPT human S404 449082 PVVsGDtsPRHLsNV X X 35834; 20194; 98523; 91600; 49562 +DYRK1A DYRK1A Q13627 human TRAF3 22031 Q60803 Traf3 mouse S29 23154950 QPDRGAGsVLVPEQG X X +DYRK1A DYRK1A Q13627 human eIF2B-epsilon 192234 Q64350 Eif2b5 rat S539 449906 ELDsRAGsPQLDDIR X +DYRK1A DYRK1A Q13627 human TRAF3 7187 Q13114 TRAF3 human S75 1875793002 CGHRFCEsCMAALLS X +DYRK1A DYRK1A Q13627 human SF2 689890 NP_001103022 Srsf1 rat S234 468704 sPRRsRGsPRYsPRH X +DYRK1A DYRK1A Q13627 human MEF2D 4209 Q14814 MEF2D human S251 3196577 NkVIPAksPPPPtHS X X +DYRK1A DYRK1A Q13627 human amphiphysin 218038 Q7TQF7 Amph mouse S293 465542 PAPVRPRsPsQtRKG X +DYRK1A DYRK1A Q13627 human CCNL2 81669 Q96S94 CCNL2 human S369 471000 AKkAkADsPVNGLPK X +DYRK1A DYRK1A Q13627 human CCND1 595 P24385 CCND1 human T286 447839 EEVDLACtPtDVRDV X X 3300; 94159 +DYRK1A DYRK1A Q13627 human amphiphysin 273 P49418 AMPH human S295 465543 PARPRsPsQTRKGPP X +DYRK1A DYRK1A Q13627 human FOXO1A 2308 Q12778 FOXO1 human S329 448076 stIsGRLsPIMtEQD X +DYRK1A DYRK1A Q13627 human PLK2 10769 Q9NYY3 PLK2 human S358 1883594400 VPDFHLSsPAKNFFK X +DYRK1A DYRK1A Q13627 human CDKL5 6792 O76039 CDKL5 human S308 15719610 RLLDRsPsRSAKRkP X X +DYRK1A DYRK1A Q13627 human CCNL2 81669 Q96S94 CCNL2 human S330 7322508 LDGtsGFsPAPKLVE X +DYRK1A DYRK1A Q13627 human SNCA 6622 P37840 SNCA human S87 449948 ktVEGAGsIAAATGF Synuclein X X +DYRK1A DYRK1A Q13627 human DYN1 1759 Q05193 DNM1 human S857 455277 AsPSRPEsPRPPFDL X X +DYRK1A DYRK1A Q13627 human RCAN1 1827 P53805 RCAN1 human S167 456023 FLIsPPAsPPVGWKQ Calcipressin X +DYRK1A DYRK1A Q13627 human Tau iso8 4137 P10636-8 MAPT human S202 447928 sGyssPGsPGtPGsR X 39357; 30505 +DYRK1A DYRK1A Q13627 human CASP9 12371 Q8C3Q9 Casp9 mouse T163 449563 PEVLRPEtPRPVDIG X X +DYRK1A DYRK1A Q13627 human TRAF3 7187 Q13114 TRAF3 human T29 23154950 HTDRSAGtPVFVPEQ X X +DYRK1A DYRK1A Q13627 human NMDAR2A 24409 Q00959 Grin2a rat S1048 36747000 NRTHSLKsPRYLPEE NMDAR2_C X X +DYRK1A DYRK1A Q13627 human amphiphysin 273 P49418 AMPH human T310 465544 VPPLPKVtPtKELQQ X +DYRK1A DYRK1A Q13627 human Tau iso8 4137 P10636-8 MAPT human T217 449078 sRtPsLPtPPtREPK X X 33134; 51625 +DYRK1A DYRK1A Q13627 human RCAN1 1827 P53805 RCAN1 human T247 21511701 QtRRPEYtPIHLS__ X +DYRK1A DYRK1A Q13627 human POLR2A 5430 P24928 POLR2A human S1616 450204 TPQSPSysPtsPsYS RNA_pol_Rpb1_R X X 4735; 13499; 13546; 31262 +DYRK1A DYRK1A Q13627 human GLI1 2735 P08151 GLI1 human S408 41595600 GPLPRAPsISTVEPk X +DYRK1A DYRK1A Q13627 human SF2 689890 NP_001103022 Srsf1 rat S238 468705 sRGsPRYsPRHsRsR X +DYRK1A DYRK1A Q13627 human DYRK1A 1859 Q13627 DYRK1A human S529 475065 SNSGRARsDPtHQHR X +DYRK1A DYRK1A Q13627 human SF2 689890 NP_001103022 Srsf1 rat S227 2303915 NSRsRsYsPRRsRGs X +DYRK1A DYRK1A Q13627 human NFAT2 4772 O95644 NFATC1 human S261 15412721 ARssRPAsPCNKRKY X +DYRK1A DYRK1A Q13627 human amphiphysin 273 P49418 AMPH human S293 465542 PAPARPRsPsQTRKG X X +DYRK1A DYRK1A Q13627 human SF3B1 23451 O75533 SF3B1 human T273 460653 AtPGRGDtPGHAtPG X +DYRK1A DYRK1A Q13627 human GYS1 100008660 P13834 GYS1 rabbit S641 448237 YRYPRPAsVPPsPSL Glycogen_syn X +DYRK1A DYRK1A Q13627 human NFAT2 4772 O95644 NFATC1 human S409 63036600 LsPTSYMsPTLPALD X +DYRK1A DYRK1A Q13627 human Tau iso8 4137 P10636-8 MAPT human T212 447934 tPGsRsRtPsLPtPP X X +DYRK1A DYRK1A Q13627 human SIRT1 93759 Q923E4 Sirt1 mouse T522 6006905 HLSELPPtPLHIsED X X +DYRK1A DYRK1A Q13627 human CCNL2 81669 Q96S94 CCNL2 human S338 11263900 PAPKLVEsPKEGKGs X +DYRK1A DYRK1A Q13627 human LIN52 91750 Q52LA3 LIN52 human S28 4758466 FEKLDRAsPDLWPEQ LIN52 X X +DYRK1A DYRK1A Q13627 human POLR2A 5430 P24928 POLR2A human S1619 447616 SPSysPtsPsYSPTS RNA_pol_Rpb1_R X X 4735; 13523; 13546; 67221 +DYRK1A DYRK1A Q13627 human SPRY2 10253 O43597 SPRY2 human T75 4145505 KPAPRPStQHkHERL X X +DYRK1A DYRK1A Q13627 human ID2 15902 P41136 Id2 mouse T27 4706880 LGISRsKtPVDDPMS X +DYRK1A DYRK1A Q13627 human NFAT2 4772 O95644 NFATC1 human S403 41453279 WAkPKPLsPTSYMsP X +DYRK1A DYRK1A Q13627 human p53 7157 P04637 TP53 human S15 447490 PsVEPPLsQEtFsDL P53_TAD X X 4030; 9235; 9284; 9286; 8695; 8514; 82530; 56979 +DYRK1A DYRK1A Q13627 human CCND3 12445 P30282 Ccnd3 mouse T283 452160 QGPSQTStPTDVTAI X 53966 +DYRK1A DYRK1A Q13627 human Tau iso8 4137 P10636-8 MAPT human T205 447933 ssPGsPGtPGsRsRt X X 25377; 43964; 53001; 49561; 20060; 33032; 30505; 20739; 98160 +DYRK1A DYRK1A Q13627 human SF3B1 23451 O75533 SF3B1 human T434 460652 PARkLtAtPtPLGGM SF3b1 X X +DYRK1A DYRK1A Q13627 human Tau iso8 4137 P10636-8 MAPT human S422 449083 GsIDMVDsPQLAtLA X X +DYRK1A DYRK1A Q13627 human TRAF3 7187 Q13114 TRAF3 human S9 5274284 ESSKKMDsPGALQTN X +DYRK1A DYRK1A Q13627 human NFAT2 4772 O95644 NFATC1 human S278 41453273 NGRQPPYsPHHsPTP X +DYRK1A DYRK1A Q13627 human amphiphysin 273 P49418 AMPH human T312 465545 PLPKVtPtKELQQEN X +HIPK1 HIPK1 Q86Z02 human MECP2 4204 P51608 MECP2 human S216 18012096 VkRVLEKsPGkLLVk X X +HIPK1 HIPK1 Q86Z02 human MECP2 4204 P51608 MECP2 human S80 452713 AVPEAsAsPKQRRsI X +HIPK1 HIPK1 Q86Z02 human PAGE4 9506 O60829 PAGE4 human T51 3913886 PGQEREGtPPIEERK GAGE X +HIPK1 HIPK1 Q86Z02 human CREB 1385 P16220 CREB1 human S257 14159739 PGVVMAssPALPTQP X +Fgfr1 FGFR1 P16092 mouse FGFR1 2260 P11362 FGFR1 human Y653 447918 RDIHHIDyykKTTNG PK_Tyr_Ser-Thr X 3471; 3476; 52928 +Fgfr1 FGFR1 P16092 mouse FGFR1 2260 P11362 FGFR1 human Y583 448702 RRPPGLEyCyNPsHN PK_Tyr_Ser-Thr X +Fgfr1 FGFR1 P16092 mouse FGFR1 2260 P11362 FGFR1 human Y585 448703 PPGLEyCyNPsHNPE PK_Tyr_Ser-Thr X +Fgfr1 FGFR1 P16092 mouse FGFR1 2260 P11362 FGFR1 human Y654 447919 DIHHIDyykKTTNGR PK_Tyr_Ser-Thr X 3471; 3476; 52928 +Fgfr1 FGFR1 P16092 mouse NLGN1 192167 Q99K10 Nlgn1 mouse Y782 1008111 RTACPPDyTLAMRRS X +Fgfr1 FGFR1 P16092 mouse FGFR1 2260 P11362 FGFR1 human Y605 448769 KDLVsCAyQVARGME PK_Tyr_Ser-Thr X +Fgfr1 FGFR1 P16092 mouse FGFR1 2260 P11362 FGFR1 human Y463 448641 MLAGVSEyELPEDPR X +Fgfr1 FGFR1 P16092 mouse FGFR3 2261 P22607 FGFR3 human Y599 464763 KDLVsCAyQVARGME PK_Tyr_Ser-Thr X +NEK3 NEK3 P51956 human NEK3 4752 P51956 NEK3 human T165 57829902 FACTYVGtPYYVPPE Pkinase X +NEK3 NEK3 P51956 human SNAP29 9342 O95721 SNAP29 human S105 56651951 MDQDLkIsQkHINsI V-SNARE_C X +Prkce PKCE P09216 rat PLCB3 29322 Q99JE6 Plcb3 rat S1105 448448 LDRKRNNsISEAKTR PLC-beta_C X 2484 +Prkce PKCE P09216 rat K8 16691 P11679 Krt8 mouse S9 484004 sIRVTQKsYkMstsG Keratin_2_head X +Prkce PKCE P09216 rat SCN10A Q62968 Scn10a rat S1452 25126701 NAMKKLGsKKPQKPI X +Prkce PKCE P09216 rat TRPV1 83810 O35433 Trpv1 rat S800 450017 VPLLRDAsTRDRHAT X X +Prkce PKCE P09216 rat Kv3.1 25327 P25122 Kcnc1 rat S503 464642 LEINRADsKLNGEVA X +Prkce PKCE P09216 rat TRPV1 83810 O35433 Trpv1 rat S502 450016 YFLQRRPsLKSLFVD Ion_trans X +Prkce PKCE P09216 rat K18 3875 P05783 KRT18 human S53 447734 IsVsrstsFrGGMGs X +Prkce PKCE P09216 rat K8 16691 P11679 Krt8 mouse S24 448538 PrAFssRsFtsGPGA Keratin_2_head X +Prkce PKCE P09216 rat GJA1 24392 P08050 Gja1 rat S368 447813 QRPssRAssRAssRP X 3511; 52559 +Prkce PKCE P09216 rat G-gamma 12 14701 Q9DAS9 Gng12 mouse S2 447876 ______MssktAstN X +Prkce PKCE P09216 rat GJA1 24392 P08050 Gja1 rat S262 450694 sPskDCGsPkyAyFN X +Mapk12 P38G Q63538 rat DLG1 25252 Q62696 Dlg1 rat S122 3195032 VLPSERIsPQVPNEV MAGUK_N_PEST X +Mapk12 P38G Q63538 rat SNTA1 6640 Q13424 SNTA1 human S193 469673 GWDsPPAsPLQRQPs X X +Mapk12 P38G Q63538 rat DLG1 1739 Q12959 DLG1 human S122 3195032 tPPQEHIsPQItNEV MAGUK_N_PEST X +Mapk12 P38G Q63538 rat DLG1 1739 Q12959 DLG1 human T209 35547401 VNTDSLEtPTYVNGT MAGUK_N_PEST X +Mapk12 P38G Q63538 rat DLG1 25252 Q62696 Dlg1 rat T209 35547401 VNTDSLEtPTYVNGT MAGUK_N_PEST X +Mapk12 P38G Q63538 rat DLG1 1739 Q12959 DLG1 human S158 2024309 FVsHsHIsPIKPTEA MAGUK_N_PEST X +Mapk12 P38G Q63538 rat DLG1 25252 Q62696 Dlg1 rat S442 5931300 YLGQTPAsPARYsPI PDZ_assoc X +Mapk12 P38G Q63538 rat DLG1 25252 Q62696 Dlg1 rat S447 15176604 PAsPARYsPISKAVL PDZ_assoc X +Mapk12 P38G Q63538 rat DLG1 25252 Q62696 Dlg1 rat S158 2024309 FVSHSHIsPIKPTEA MAGUK_N_PEST X +Mapk12 P38G Q63538 rat SNTA1 6640 Q13424 SNTA1 human S201 4729592 PLQRQPssPGPtPRN X X +Mapk12 P38G Q63538 rat DLG1 25252 Q62696 Dlg1 rat S431 4749386 QSVDNHVsPSSYLGQ PDZ_assoc X +NEK11 NEK11 Q8NG66 human CDC25A 993 P30304 CDC25A human S82 450248 GssEstDsGFCLDsP X X +NEK11 NEK11 Q8NG66 human BLM 641 P54132 BLM human S338 4700251 kEDVLSTskDLLskP BLM_N X X +NEK11 NEK11 Q8NG66 human CDC25A 993 P30304 CDC25A human S88 458298 DsGFCLDsPGPLDSK M-inducer_phosp X X +NEK11 NEK11 Q8NG66 human CDC25A 993 P30304 CDC25A human S79 450247 QRMGssEstDsGFCL X +PIK3R1 PIK3R1 P27986 human Akt1 207 P31749 AKT1 human S473 447855 RPHFPQFsysAsGtA Pkinase_C X 9271; 3787; 4060; 4051; 5102; 4058; 2336; 2337; 4075; 4070; 5012; 4071; 92982; 5315; 9563; 9018; 12694; 52240; 11962; 15116; 88106; 26580; 68035; 31957; 23430; 20235 +Plk1 PLK1 Q07832 mouse IRS2 384783 P81122 Irs2 mouse S1098 3217320 TsGLKRLsLMDQVSG X X +Plk1 PLK1 Q07832 mouse CELSR1 12614 O35161 Celsr1 mouse S2741 27446069 KKLQLDDsATTRATL X +Plk1 PLK1 Q07832 mouse CELSR1 12614 O35161 Celsr1 mouse S2752 31884511 RATLLtRsLNCNNTY X +Plk1 PLK1 Q07832 mouse CELSR1 12614 O35161 Celsr1 mouse T2750 41159600 TTRATLLtRsLNCNN X +Plk1 PLK1 Q07832 mouse HSF1 15499 P38532 Hsf1 mouse S415 455264 SALLDLFsPSVTMPD Vert_HS_TF X X +Plk1 PLK1 Q07832 mouse IRS1 3667 P35568 IRS1 human S24 455604 GYLRKPKsMHKRFFV PH X +Plk1 PLK1 Q07832 mouse TPT1 22070 P63028 Tpt1 mouse S64 3146607 PEGEGTEsTVVTGVD TCTP X +Plk1 PLK1 Q07832 mouse RIPK3 56532 Q9QZL0 Ripk3 mouse S369 27928505 ERQAQDTsVGPAtPA X +Plk1 PLK1 Q07832 mouse TPT1 22070 P63028 Tpt1 mouse S46 476067 TEGAIDDsLIGGNAs TCTP X 5251 +Plk1 PLK1 Q07832 mouse CDK5RAP2 214444 Q8K389 Cdk5rap2 mouse S608 41285495 KALQEQLsEIRSREE X +Plk1 PLK1 Q07832 mouse IRS2 384783 P81122 Irs2 mouse S556 470895 GRPYRRVsGDGAQDL X X +Ripk4 ANKRD3 Q9ERK0 mouse IRF6 54139 P97431 Irf6 mouse S90 56649936 LRCALNKsREFNLMY IRF X +Ripk4 ANKRD3 Q9ERK0 mouse IRF6 54139 P97431 Irf6 mouse S424 27451041 GsVRLQIstPDIKDN X X +Ripk4 ANKRD3 Q9ERK0 mouse IRF6 54139 P97431 Irf6 mouse S413 18911095 FSGDFTRsFDSGsVR X X +Prkd1 PRKD1 Q62101 mouse HDAC7 51564 Q8WUI4 HDAC7 human S486 452459 RPLsRAQssPAAPAs X 3424 +Prkd1 PRKD1 Q62101 mouse PRKD1 18760 Q62101 Prkd1 mouse S744 448589 ARIIGEksFRRsVVG Pkinase X 2054 +Prkd1 PRKD1 Q62101 mouse PRKD2 101540 Q8BZ03 Prkd2 mouse S873 448800 QGLAERIsIL_____ X +Prkd1 PRKD1 Q62101 mouse TNNI3 29248 P23693 Tnni3 rat S23 448423 PAPVRRRssANYRAY Troponin-I_N X X 4004 +Prkd1 PRKD1 Q62101 mouse PRKD1 5587 Q15139 PRKD1 human S910 447632 KALGERVsIL_____ X 2051; 75148 +Prkd1 PRKD1 Q62101 mouse PRKD1 18760 Q62101 Prkd1 mouse S748 448590 GEksFRRsVVGtPAy Pkinase X 2054 +Prkd1 PRKD1 Q62101 mouse HDAC7 51564 Q8WUI4 HDAC7 human S155 455620 FPLRKtVsEPNLkLR X 3443 +Prkd1 PRKD1 Q62101 mouse PRKD1 18760 Q62101 Prkd1 mouse S916 447632 KALSERVsIL_____ X X 2051; 75148 +Prkd1 PRKD1 Q62101 mouse HDAC7 51564 Q8WUI4 HDAC7 human S358 455621 WPLsRtRsEPLPPsA X +Prkd1 PRKD1 Q62101 mouse MYBPC3 17868 O70468 Mybpc3 mouse S302 471081 sLLKKRDsFRRDskL X X +Prkd1 PRKD1 Q62101 mouse PRKD1 18760 Q62101 Prkd1 mouse S203 449896 GVRRRRLsNVsLTGL X +Prkd1 PRKD1 Q62101 mouse TNNI3 29248 P23693 Tnni3 rat S24 448424 APVRRRssANYRAYA Troponin-I_N X X 4004 +PGK1 PGK1 P00558 human beclin 1 8678 Q14457 BECN1 human S30 7446159 QPLkLDTsFkILDRV X X 54101; 35955 +PGK1 PGK1 P00558 human VASP 7408 P50552 VASP human S239 448380 GAKLRKVsKQEEASG X 3114; 37565 +PGK1 PGK1 P00558 human PRAS40 84335 Q96B36 AKT1S1 human T246 470067 LPRPRLNtsDFQkLK PRAS X X 2640; 2997; 32263; 13175; 60202 +PGK1 PGK1 P00558 human PDHK1 5163 Q15118 PDK1 human T338 54390604 LFNYMyStAPRPRVE HATPase_c X +PGK1 PGK1 P00558 human PGK1 5230 P00558 PGK1 human Y324 5233200 GPESSkkyAEAVTRA PGK X X +Met Met P16056 mouse Met 17295 P16056 Met mouse Y1233 448471 DMyDKEyysVHNKtG PK_Tyr_Ser-Thr X 4091; 3129; 3126; 3077; 12468; 4033; 98954 +Met Met P16056 mouse GAB1 14388 Q9QYY0 Gab1 mouse Y407 447946 DASsQDCyDIPRtFP X +Met Met P16056 mouse GAB1 14388 Q9QYY0 Gab1 mouse Y628 447948 KGDKQVEyLDLDLDs X 3231; 3233 +Met Met P16056 mouse GAB1 14388 Q9QYY0 Gab1 mouse Y373 447945 ASDtDSSyCIPPPAG X +Met Met P16056 mouse GAB1 14388 Q9QYY0 Gab1 mouse Y285 449801 TEADGELyTFNTPSG X +Met Met P16056 mouse RALGDS 19730 Q03385 Ralgds mouse Y752 59087905 DVDNGNMyKSILVTS RA X +Met Met P16056 mouse GAB1 14388 Q9QYY0 Gab1 mouse Y448 449791 GEELDENyVPMNPNs X +Met Met P16056 mouse GAB1 14388 Q9QYY0 Gab1 mouse Y590 449792 SHDSEENyVPMNPNL X +Met Met P16056 mouse GAB1 14388 Q9QYY0 Gab1 mouse Y473 447947 EPIQEPNyVPMtPGT X +Met Met P16056 mouse GAB1 14388 Q9QYY0 Gab1 mouse Y660 447949 MADERVDyVVVDQQK X 12745 +Met Met P16056 mouse GAB1 14388 Q9QYY0 Gab1 mouse Y307 447944 MRHVsISyDIPPtPG X 3234 +Met Met P16056 mouse Met 17295 P16056 Met mouse Y1232 448470 rDMyDKEyysVHNKt PK_Tyr_Ser-Thr X 4091; 3129; 3126; 3077; 12468; 4033; 98954 +JAK2 JAK2 O60674 human GTF2I iso2 2969 P78347-2 GTF2I human Y248 448250 EESEDPDyyQyNIQG X X +JAK2 JAK2 O60674 human beclin 1 8678 Q14457 BECN1 human Y333 1874101912 QRYRLVPyGNHsYLE APG6 X +JAK2 JAK2 O60674 human PAK1 5058 Q13153 PAK1 human Y285 487520 QGASGTVyTAMDVAT Pkinase X X +JAK2 JAK2 O60674 human PRMT5 10419 O14744 PRMT5 human Y307 18545700 FAKGyEDyLQsPLQP PRMT5 X X +JAK2 JAK2 O60674 human STAP2 55620 Q9UGK3 STAP2 human Y250 478353 PFLLDEDyEKVLGyV X +JAK2 JAK2 O60674 human GRB2 2885 P62993 GRB2 human Y209 448512 TGMFPRNyVtPVNrN X +JAK2 JAK2 O60674 human EPOR 13857 P14753 Epor mouse Y503 449885 SEPLHPGyVACS___ X +JAK2 JAK2 O60674 human PRLR 5618 P16471 PRLR human S349 451641 YLDPDTDsGRGSCDs X +JAK2 JAK2 O60674 human EZH2 2146 Q15910 EZH2 human Y641 31825502 kNEFISEyCGEIISQ SET X X +JAK2 JAK2 O60674 human STAT5A 6776 P42229 STAT5A human Y694 447767 LAkAVDGyVkPQIkQ X 9365; 9356; 9359; 9351; 4322; 9314; 3939; 40284; 5387; 14603; 66740; 51879; 72712 +JAK2 JAK2 O60674 human PPDPF 79144 Q9H3Y8 PPDPF human Y17 1883583900 LVATHDyyRRRLGst X X +JAK2 JAK2 O60674 human CCR2 729230 P41597 CCR2 human Y139 448635 ILLTIDRyLAIVHAV 7tm_1 X +JAK2 JAK2 O60674 human JMJD1A 55818 Q9Y4C1 KDM3A human Y1101 462537 PDLGPKMyNAyGLIT X +JAK2 JAK2 O60674 human STAT5B 20851 P42232 Stat5b mouse Y699 448198 TAkAADGyVKPQIKQ X 9365; 9356; 9359; 9351; 4322; 9314; 3939; 40284; 5387; 14603; 66740; 51879; 72712 +JAK2 JAK2 O60674 human BRD4 23476 O60885 BRD4 human Y98 1874101904 kLNLPDyykIIKtPM Bromodomain X X +JAK2 JAK2 O60674 human JAK2 3717 O60674 JAK2 human Y570 451494 VRREVGDyGQLHETE PK_Tyr_Ser-Thr X X +JAK2 JAK2 O60674 human PAK1 5058 Q13153 PAK1 human Y153 463955 tDksAEDyNssNALN X X +JAK2 JAK2 O60674 human GRB2 2885 P62993 GRB2 human Y52 7388002 DGFIPkNyIEMkPHP X +JAK2 JAK2 O60674 human SOCS3 9021 O14543 SOCS3 human Y221 450447 IREFLDQyDAPL___ X +JAK2 JAK2 O60674 human STAT3 6774 P40763 STAT3 human Y705 448192 DPGsAAPyLktKFIC X X 4093; 9145; 4324; 9131; 9138; 4323; 4074; 4113; 48313; 20977; 25023; 8119; 52075; 52527; 73533; 61958; 73452; 16185; 74309 +JAK2 JAK2 O60674 human CTLA-4 12477 P09793 Ctla4 mouse Y201 450897 SPLTTGVyVKMPPTE X X +JAK2 JAK2 O60674 human PRMT5 10419 O14744 PRMT5 human Y304 18545701 yELFAKGyEDyLQsP PRMT5 X X +JAK2 JAK2 O60674 human STAP2 55620 Q9UGK3 STAP2 human Y22 11500606 GVLPSHYyESFLEKK PH X +JAK2 JAK2 O60674 human GAB2 9846 Q9UQC2 GAB2 human Y643 450913 tsDEKVDyVQVDKEK X X +JAK2 JAK2 O60674 human EPOR 13857 P14753 Epor mouse Y453 455531 PTPPHLKyLyLVVSD X +JAK2 JAK2 O60674 human ASK1 4217 Q99683 MAP3K5 human Y718 458209 IPERDSRySQPLHEE Pkinase X X +JAK2 JAK2 O60674 human EPOR 13857 P14753 Epor mouse Y455 455532 PPHLKyLyLVVSDSG X +JAK2 JAK2 O60674 human ARHGEF1 9138 Q92888 ARHGEF1 human Y738 13421400 WDQEAQIyELVAQTV PH_16 X X +JAK2 JAK2 O60674 human SOCS3 12702 O35718 Socs3 mouse Y204 450446 VNGHLDSyEKVTQLP X +JAK2 JAK2 O60674 human STAT3 20848 P42227 Stat3 mouse Y705 448192 DPGsAAPyLktkFIC X 4093; 9145; 4324; 9131; 9138; 4323; 4074; 4113; 48313; 20977; 25023; 8119; 52075; 52527; 73533; 61958; 73452; 16185; 74309 +JAK2 JAK2 O60674 human H3 8350 P68431 H3C1 human Y41 10897613 GVkkPHryrPGtVAL Histone X X +JAK2 JAK2 O60674 human GRB2 2885 P62993 GRB2 human Y37 7388001 EECDQNWykAELNGk SH3_1 X +JAK2 JAK2 O60674 human CBP 12914 P45481 Crebbp mouse Y1126 55377870 QLLGIPDyFDIVKNP Bromodomain X X +JAK2 JAK2 O60674 human GRB2 2885 P62993 GRB2 human Y7 478849 _MEAIAkyDFkATAD SH3_1 X +JAK2 JAK2 O60674 human ATOH1 11921 P48985 Atoh1 mouse Y78 386186604 CTARAAQyLLHSPEL X +JAK2 JAK2 O60674 human JAK2 3717 O60674 JAK2 human S523 465671 GVsDVPtsPTLQRPT X X +JAK2 JAK2 O60674 human PPDPF 79144 Q9H3Y8 PPDPF human Y16 1883583902 sLVATHDyyRRRLGs X X +JAK2 JAK2 O60674 human STAP2 55620 Q9UGK3 STAP2 human Y322 3974222 GDGPAVDyENQDVAS X +JAK2 JAK2 O60674 human PRLR 19116 Q08501 Prlr mouse Y532 3188101 VPETSKEyAKVSGVT X +JAK2 JAK2 O60674 human TET2 54790 Q6N021 TET2 human Y1964 1870020001 HETSEPTyLRFIKSL X X +JAK2 JAK2 O60674 human Chk2 11200 O96017 CHEK2 human Y156 1877718908 EVGPKNSyIAYIEDH FHA X X +JAK2 JAK2 O60674 human PBK 55872 Q96KB5 PBK human Y74 473837 NPICNDHyRsVyQkR Pkinase X X +JAK2 JAK2 O60674 human STAP2 55620 Q9UGK3 STAP2 human Y310 6155352 LPNQEENyVTPIGDG X +JAK2 JAK2 O60674 human PRMT5 10419 O14744 PRMT5 human Y297 18545702 NRPPPNAyELFAKGy PRMT5 X X +JAK2 JAK2 O60674 human STAT5A 443419 P42231 STAT5A sheep Y694 447767 LAKAVDGyVKPQIKQ X 9365; 4322; 3939; 5387; 14603; 66740; 72712 +JAK2 JAK2 O60674 human ERK2 5594 P28482 MAPK1 human Y187 447594 HtGFLtEyVAtRWyr Pkinase X 9106; 4370; 4374; 9101; 4375; 4376; 4377; 3510; 5726; 88569; 13214; 13148; 70235; 9488; 89967; 8544; 14196; 14227; 14095; 14474; 75165; 98168; 33370; 54240; 15892; 45899; 55088; 9524; 69217; 48735 +JAK2 JAK2 O60674 human JAK2 16452 Q62120 Jak2 mouse Y1007 448407 VLPQDKEyyKVKEPG PK_Tyr_Ser-Thr X 3771; 3776; 4406; 66245; 32901 +JAK2 JAK2 O60674 human SMARCA3 100009232 Q95216 HLTF rabbit Y195 18707503 SGRAGPSySMPVHAA X X +JAK2 JAK2 O60674 human JAK2 3717 O60674 JAK2 human Y119 470132 VLYRIRFyFPRWYCS FERM_F1 X +JAK2 JAK2 O60674 human PDHA1 5160 P08559 PDHA1 human Y301 454753 MsDPGVsyRtREEIQ E1_dh X +JAK2 JAK2 O60674 human SOCS3 9021 O14543 SOCS3 human Y204 450446 VNGHLDSyEkVTQLP X +JAK2 JAK2 O60674 human PDHK1 5163 Q15118 PDK1 human Y243 462384 ARRLCDLyyINSPEL X +JAK2 JAK2 O60674 human BRD4 23476 O60885 BRD4 human Y97 1874101902 VkLNLPDyykIIKtP Bromodomain X X +JAK2 JAK2 O60674 human ERK1 5595 P27361 MAPK3 human Y204 447543 HtGFLtEyVAtRWyr Pkinase X 9106; 4370; 4374; 9101; 4375; 4376; 4377; 3510; 5726; 88569; 13214; 13148; 70235; 9488; 89967; 8544; 14196; 14227; 14095; 14474; 75165; 98168; 33370; 54240; 15892; 45899; 55088; 9524; 69217; 48735 +JAK2 JAK2 O60674 human PAK1 5058 Q13153 PAK1 human Y201 487519 PEHtKsVyTRsVIEP X X +JAK2 JAK2 O60674 human TET2 54790 Q6N021 TET2 human Y1939 1870020000 CEKYGPDyVPQKSHG X X +JAK2 JAK2 O60674 human STAT1 6772 P42224 STAT1 human Y701 447754 DGPkGtGyIktELIs X X 9174; 9167; 5375; 25685; 8062; 8183; 8009; 55603; 7649; 25809; 57216; 45118; 39205; 88845; 88211; 76285; 90145 +CDK4 CDK4 P11802 human Rb 5925 P06400 RB1 human S780 447978 strPPtLsPIPHIPr Rb_C X X 9307; 3590; 8180 +CDK4 CDK4 P11802 human TFEB 7942 P19484 TFEB human S467 4785142 KASsRRssFsMEEGD DUF3371 X +CDK4 CDK4 P11802 human C/EBP-alpha 12606 P53566 Cebpa mouse S193 1868113505 PPPHPHAsPAHLAAP X X +CDK4 CDK4 P11802 human Rb-like 2 5934 Q08999 RBL2 human T401 449723 SKALRIStPLtGVRY X +CDK4 CDK4 P11802 human TFEB 7942 P19484 TFEB human T331 3181634 RVHGLPttsPsGMNM DUF3371 X +CDK4 CDK4 P11802 human FOXM1 2305 Q08050 FOXM1 human T510 22648003 EDSSQsPtPRPKKSy X +CDK4 CDK4 P11802 human CDC25A 993 P30304 CDC25A human S40 63080405 ASAAGGLsPVTNLTV X +CDK4 CDK4 P11802 human FOXO1A 2308 Q12778 FOXO1 human S249 471071 EGGkSGksPrRrAAs X X +CDK4 CDK4 P11802 human p73 7161 O15350 TP73 human T86 449047 AASASPYtPEHAASV X +CDK4 CDK4 P11802 human DNMT1 1786 P26358 DNMT1 human S127 3189388 VGMADANsPPKPLsk X +CDK4 CDK4 P11802 human MEF2D 4209 Q14814 MEF2D human S98 470518 KGFNGCDsPEPDGED HJURP_C X +CDK4 CDK4 P11802 human FOXM1 2305 Q08050 FOXM1 human T611 451437 ETLPISstPSkSVLP X X +CDK4 CDK4 P11802 human TSC2 7249 P49815 TSC2 human S1452 3191272 LPSssPRsPsGLrPr X X +CDK4 CDK4 P11802 human FOXM1 2305 Q08050 FOXM1 human S508 22648001 sWEDSSQsPtPRPKK X +CDK4 CDK4 P11802 human EGLN2 112398 Q96KS0 EGLN2 human S130 31088285 EDGGDAPsPsKRPWA X +CDK4 CDK4 P11802 human E2A 6929 P15923 TCF3 human S245 455906 PMLGGGSsPLPLPPG X +CDK4 CDK4 P11802 human WDR77 79084 Q9BQA1 WDR77 human S264 17797201 CVTGLVFsPHSVPFL X +CDK4 CDK4 P11802 human VCP 7415 P55072 VCP human S664 7435526 LkANLRksPVAkDVD X +CDK4 CDK4 P11802 human DNMT1 1786 P26358 DNMT1 human S954 452278 TFNIKLSsPVkRPRk BAH X +CDK4 CDK4 P11802 human TFEB 7942 P19484 TFEB human S211 25529700 LVGVTSSsCPADLTQ X 37681 +CDK4 CDK4 P11802 human Rb 5925 P06400 RB1 human T356 447981 DsFEtQRtPRksNLD X 81403; 99158 +CDK4 CDK4 P11802 human Rb 24708 P33568 Rb1 rat S787 447979 sPYKFSSsPLRIPGG Rb_C X 9301 +CDK4 CDK4 P11802 human FOXM1 2305 Q08050 FOXM1 human S522 8146040 KSySGLRsPtRCVSE X +CDK4 CDK4 P11802 human Rb 5925 P06400 RB1 human T826 447984 LPtPtkMtPRsRILV Rb_C X +CDK4 CDK4 P11802 human Rb 19645 P13405 Rb1 mouse S804 448717 IyIsPLksPyKIsEG Rb_C X 9308; 8974; 4277; 40283; 8957; 8516; 11917; 41359; 75864 +CDK4 CDK4 P11802 human E2A 6929 P15923 TCF3 human S139 455905 LNsPGPLsPsGMKGT X +CDK4 CDK4 P11802 human Rb-like 2 5934 Q08999 RBL2 human S672 448254 tLyDRySsPPAsTtR X +CDK4 CDK4 P11802 human IRS2 384783 P81122 Irs2 mouse S388 1984215 sVAGsPLsPGPVRAP X +CDK4 CDK4 P11802 human FLCN 201163 Q8NFG4 FLCN human S571 31085315 HLMSTVRsPTASESR X X +CDK4 CDK4 P11802 human Rb 5925 P06400 RB1 human S795 447979 sPykFPssPLrIPGG Rb_C X 9301 +CDK4 CDK4 P11802 human ATOH1 11921 P48985 Atoh1 mouse S309 57761909 MMAQKDLsPsLPGGI X +CDK4 CDK4 P11802 human AML2 864 Q13761 RUNX3 human S356 7705800 SSSGGDRsPTRMLAS RunxI X X +CDK4 CDK4 P11802 human CELF1 10658 Q92879 CELF1 human S302 3347301 TSSGSsPsSSSSNSV X +CDK4 CDK4 P11802 human Rb 5925 P06400 RB1 human T252 449821 PINGsPRtPRRGQNR X X +CDK4 CDK4 P11802 human Rb-like 1 5933 P28749 RBL1 human S975 450986 HIKQQPGsPRRIsQQ Rb_C X +CDK4 CDK4 P11802 human Rb-like 1 5933 P28749 RBL1 human T369 451295 KRSFAPstPLtGRRY X +CDK4 CDK4 P11802 human CELF1 13046 P28659 Celf1 mouse S302 3347301 TSSGSSPsSSSSNSV X +CDK4 CDK4 P11802 human GCN5 2648 Q92830 KAT2A human T272 33703200 LNYWKLEtPAQFRQR PCAF_N X X +CDK4 CDK4 P11802 human GATA4 2626 P43694 GATA4 human S105 449604 AYTPPPVsPRFsFPG GATA-N X X +CDK4 CDK4 P11802 human Rb 5925 P06400 RB1 human S788 450022 PIPHIPrsPykFPss Rb_C X +CDK4 CDK4 P11802 human FOXM1 2305 Q08050 FOXM1 human T627 3194576 tPEsWRLtPPAKVGG X X +CDK4 CDK4 P11802 human p21Cip1 1026 P38936 CDKN1A human S98 478193 GGRRPGTsPALLQGT X +CDK4 CDK4 P11802 human Rb 5925 P06400 RB1 human S249 447975 AVIPINGsPRtPRRG X X +CDK4 CDK4 P11802 human SMAD3 4088 P84022 SMAD3 human T179 451177 PQSNIPEtPPPGYLS X +CDK4 CDK4 P11802 human Rb-like 2 5934 Q08999 RBL2 human S1035 449738 NMDAPPLsPyPFVRt X +CDK4 CDK4 P11802 human SMAD3 4088 P84022 SMAD3 human S213 451180 NLsPNPMsPAHNNLD X +CDK4 CDK4 P11802 human Rb 5925 P06400 RB1 human S612 447977 MyLsPVRsPKKKGsT X +CDK4 CDK4 P11802 human FLCN 201163 Q8NFG4 FLCN human S73 3206877 GAsVEsssPGPKKSD X X +CDK4 CDK4 P11802 human FOXM1 2305 Q08050 FOXM1 human S704 449265 IDVPKPGsPEPQVSG X +CDK4 CDK4 P11802 human TFEB 7942 P19484 TFEB human S142 3181628 AGNsAPNsPMAMLHI MITF_TFEB_C_3_N X X +CDK4 CDK4 P11802 human AML3 860 Q13950 RUNX2 human S465 460684 MVPGGDRsPSRMLPP RunxI X +CDK4 CDK4 P11802 human Rb-like 1 5933 P28749 RBL1 human S640 451296 RRDMQPLsPIsVHER X +CDK4 CDK4 P11802 human PELP1 27043 Q8IZL8 PELP1 human S477 470174 ADALKLRsPRGsPDG NUC202 X X +CDK4 CDK4 P11802 human IRS2 384783 P81122 Irs2 mouse S1226 27451056 GCPGGSSsPMRRETS X +CDK4 CDK4 P11802 human p21Cip1 1026 P38936 CDKN1A human S130 455618 sGEQAEGsPGGPGDs X +CDK4 CDK4 P11802 human GATA4 14463 Q08369 Gata4 mouse S160 31834900 GFAGSYSsPYPAYMA GATA-N X +CDK4 CDK4 P11802 human FOXM1 2305 Q08050 FOXM1 human S489 22648002 PPLEEWPsPAPSFkE X X +CDK4 CDK4 P11802 human SMAD3 4088 P84022 SMAD3 human S208 451179 DAGsPNLsPNPMsPA X +CDK4 CDK4 P11802 human BRCA1 672 P38398 BRCA1 human S632 478486 LVVSRNLsPPNCTEL X X +CDK4 CDK4 P11802 human TFEB 7942 P19484 TFEB human S114 3181613 HIsPAQGsPkPPPAA MITF_TFEB_C_3_N X +CDK4 CDK4 P11802 human SMAD3 4088 P84022 SMAD3 human S204 451178 NHSMDAGsPNLsPNP X +CDK4 CDK4 P11802 human FOXM1 2305 Q08050 FOXM1 human S4 22648000 ____MKTsPRRPLIL X +CDK4 CDK4 P11802 human GCN5 2648 Q92830 KAT2A human S372 33703201 EEIYGANsPIWESGF X X +CDK4 CDK4 P11802 human TFE3 7030 P19532 TFE3 human S246 56653430 PTGSAPNsPMALLTI MITF_TFEB_C_3_N X X +CDK4 CDK4 P11802 human FLNA 2316 P21333 FLNA human S2152 451357 tRRRRAPsVANVGsH Filamin X 4761 +CDK4 CDK4 P11802 human Rb 5925 P06400 RB1 human T373 447982 VNVIPPHtPVRTVMN RB_A X +CDK4 CDK4 P11802 human SOD2 6648 P04179 SOD2 human S106 7577901 SIFWTNLsPNGGGEP Sod_Fe_N X X +CDK4 CDK4 P11802 human RPRM 56475 Q9NS64 RPRM human S98 15722493 LVKDRRPsKEVEAVV X X +CDK4 CDK4 P11802 human MDM4 4194 O15151 MDM4 human S314 62381100 TECKKFNsPSKRYCF zf-RanBP X +CDK4 CDK4 P11802 human FOXM1 2305 Q08050 FOXM1 human T600 478080 EVGGPFKtPIkETLP X 14655 +CDK4 CDK4 P11802 human p53 7157 P04637 TP53 human R249 394791401 CMGGMNRrPILTIIT P53 X X +CDK4 CDK4 P11802 human Rb-like 1 5933 P28749 RBL1 human S964 451297 MMDAPPLsPFPHIKQ Rb_C X +CDK4 CDK4 P11802 human VCP 7415 P55072 VCP human T509 4271173 kFLkFGMtPskGVLF X +CDK4 CDK4 P11802 human TOB2 10766 Q14106 TOB2 human S254 14161520 PAPQSQLsPNAKEFV PAM2 X +CDK4 CDK4 P11802 human Rb 5925 P06400 RB1 human S608 447976 tAADMyLsPVRsPKK X 2181; 8147 +CDK4 CDK4 P11802 human Rb 5925 P06400 RB1 human S807 447980 PGGNIyIsPLksPyk Rb_C X X 9308; 8974; 4277; 40283; 8957; 8516; 11917; 99274; 41359; 75864; 72443 +CDK4 CDK4 P11802 human FLNA 2316 P21333 FLNA human S1459 452266 kCsGPGLsPGMVRAN Filamin X +CDK4 CDK4 P11802 human SMAD3 4088 P84022 SMAD3 human T8 452179 MSSILPFtPPIVkRL X +CDK4 CDK4 P11802 human FOXM1 2305 Q08050 FOXM1 human T620 3194573 SkSVLPRtPEsWRLt X X +CDK4 CDK4 P11802 human WDR77 79084 Q9BQA1 WDR77 human S306 17976600 FVRDATWsPLNHSLL X +CDK4 CDK4 P11802 human SPOP 8405 O43791 SPOP human S6 36136244 __MSRVPsPPPPAEM X +CDK4 CDK4 P11802 human RASSF1 iso2 11186 Q9NS23-2 RASSF1 human S203 484000 TsVRRRtsFYLPKDA RA X X +CDK4 CDK4 P11802 human TSC2 7249 P49815 TSC2 human S1217 1868502602 MSLENPLsPFSSDIN X +CDK4 CDK4 P11802 human Rb 5925 P06400 RB1 human S811 448717 IyIsPLksPykIsEG Rb_C X X 9308; 8974; 4277; 40283; 8957; 8516; 11917; 41359; 75864; 63276 +CDK4 CDK4 P11802 human WDR77 79084 Q9BQA1 WDR77 human T5 471217 ___MRkEtPPPLVPP X +CDK4 CDK4 P11802 human FOXM1 2305 Q08050 FOXM1 human S451 7320841 LLFGEGFsPLLPVQT X +CDK4 CDK4 P11802 human MEF2D 4209 Q14814 MEF2D human S110 470517 GEDsLEQsPLLEDKy HJURP_C X +CDK4 CDK4 P11802 human FLCN 201163 Q8NFG4 FLCN human S62 3206874 NSRMRAHsPAEGAsV X X +CDK4 CDK4 P11802 human Rb 19645 P13405 Rb1 mouse S800 447980 PGGNIyIsPLksPyK Rb_C X 9308; 8974; 4277; 40283; 8957; 8516; 11917; 41359; 75864; 72443 +CDK4 CDK4 P11802 human FOXM1 2305 Q08050 FOXM1 human S35 11092388 SEEEPKRsPAQQEsN X 14170 +Csnk1a1 CK1A Q8BK63 mouse NANOG 71950 Q80Z64 Nanog mouse S131 1870790708 QQMQELssILNLSYk Homeodomain X +Csnk1a1 CK1A Q8BK63 mouse CTNNB1 12387 Q02248 Ctnnb1 mouse S45 447488 GATtTAPsLsGkGNP X 9565; 9564; 24710; 70034; 19807; 96727; 77605 +Csnk1a1 CK1A Q8BK63 mouse NANOG 71950 Q80Z64 Nanog mouse S130 1870790707 LQQMQELssILNLSY Homeodomain X +Melk MELK Q61846 mouse SMAD7 4092 O15105 SMAD7 human T96 15613800 EADLKALtHSVLkKL MH1 X X +Melk MELK Q61846 mouse p21Cip1 1026 P38936 CDKN1A human T55 1869957900 RWNFDFVtEtPLEGD CDI X X +Melk MELK Q61846 mouse TXN 7295 P10599 TXN human T76 28716000 CEVKCMPtFQFFkKG Thioredoxin X X +Melk MELK Q61846 mouse PDK1 5170 O15530 PDPK1 human T354 25256100 WENLHQQtPPKLTAY X +Melk MELK Q61846 mouse SMAD2 4087 Q15796 SMAD2 human S245 448794 NQsMDTGsPAELsPT X X 3104 +Melk MELK Q61846 mouse p53 22059 P02340 Tp53 mouse S18 447490 IsLELPLsQEtFsGL P53_TAD X X 9284; 9286; 12571; 56979 +Melk MELK Q61846 mouse ASK1 26408 O35099 Map3k5 mouse T845 448394 GINPCtEtFTGtLQY Pkinase X X 3765 +Melk MELK Q61846 mouse SMAD4 4089 Q13485 SMAD4 human S343 15613801 GETFKVPsSCPIVTV MH2 X X +Melk MELK Q61846 mouse SMAD3 4088 P84022 SMAD3 human S204 451178 NHSMDAGsPNLsPNP X X +Melk MELK Q61846 mouse STRAP 20901 Q9Z1Z2 Strap mouse S188 38410205 NFNMSVSsMEYIPEG X X +MAP3K3 MEKK3 Q99759 human GLI1 2735 P08151 GLI1 human S201 1034327200 PLEGDMSsPNstGIQ X +MAP3K3 MEKK3 Q99759 human GLI1 2735 P08151 GLI1 human S243 27708601 DCRWDGCsQEFDSQE X +MAP3K3 MEKK3 Q99759 human RCAN1 1827 P53805 RCAN1 human S163 456022 PDKQFLIsPPAsPPV Calcipressin X +MAP3K3 MEKK3 Q99759 human RCAN1 1827 P53805 RCAN1 human S167 456023 FLIsPPAsPPVGWKQ Calcipressin X +MAP3K3 MEKK3 Q99759 human GLI1 2735 P08151 GLI1 human T1074 41595601 QRGSsGHtPPPsGPP X 35875 +MAP3K3 MEKK3 Q99759 human GLI1 2735 P08151 GLI1 human S1078 1034327202 sGHtPPPsGPPNMAV X +MAP3K3 MEKK3 Q99759 human ANKRD3 72388 Q9ERK0 Ripk4 mouse T184 2926100 SMDGLFGtIAYLPPE Pkinase X X +MAP3K3 MEKK3 Q99759 human p47phox 17969 Q09014 Ncf1 mouse S208 465580 KRGWVPAsYLEPLDS X +MAP3K3 MEKK3 Q99759 human GLI1 2735 P08151 GLI1 human S968 1034327201 SGSYPTPsPCHENFV X +MAP3K3 MEKK3 Q99759 human GLI1 2735 P08151 GLI1 human S204 34426682 GDMSsPNstGIQDPL X + CDK5 no information HMGB1 25459 P63159 Hmgb1 rat S181 20506700 GVVkAEKsKKKKEEE X + CDK5 no information HMGB1 25459 P63159 Hmgb1 rat K3 459196 _____MGkGDPKKPR X +Plk4 PLK4 Q64702 mouse PLK4 20873 Q64702 Plk4 mouse S285 12654000 TVEDsMDsGHAtLst X +Plk4 PLK4 Q64702 mouse PLK4 20873 Q64702 Plk4 mouse S297 12654005 LsttItAssGtsLsG X +Plk4 PLK4 Q64702 mouse PLK4 20873 Q64702 Plk4 mouse S282 12654003 DVGTVEDsMDsGHAt X +Plk4 PLK4 Q64702 mouse PLK4 20873 Q64702 Plk4 mouse T295 12654001 AtLsttItAssGtsL X +Plk4 PLK4 Q64702 mouse PLK4 20873 Q64702 Plk4 mouse T293 12654011 GHAtLsttItAssGt X +Plk4 PLK4 Q64702 mouse PLK4 20873 Q64702 Plk4 mouse S303 12654008 AssGtsLsGsLLDRR X +Plk4 PLK4 Q64702 mouse PLK4 20873 Q64702 Plk4 mouse S305 12122401 sGtsLsGsLLDRRLL X +Plk4 PLK4 Q64702 mouse PLK4 20873 Q64702 Plk4 mouse S291 12654010 DsGHAtLsttItAss X +Plk4 PLK4 Q64702 mouse PLK4 20873 Q64702 Plk4 mouse T300 12654006 tItAssGtsLsGsLL X +Plk4 PLK4 Q64702 mouse PLK4 20873 Q64702 Plk4 mouse S301 12654009 ItAssGtsLsGsLLD X +Plk4 PLK4 Q64702 mouse PLK4 20873 Q64702 Plk4 mouse S298 12654004 sttItAssGtsLsGs X +Plk4 PLK4 Q64702 mouse PLK4 20873 Q64702 Plk4 mouse T289 12654002 sMDsGHAtLsttItA X +Plk4 PLK4 Q64702 mouse PLK4 20873 Q64702 Plk4 mouse T292 12654007 sGHAtLsttItAssG X +Mapk3 ERK1 Q63844 mouse IRF3 54131 P70671 Irf3 mouse S171 6370303 DPSQQLPsPNVNNFL X +Mapk3 ERK1 Q63844 mouse IRS1 16367 P35569 Irs1 mouse S612 447562 DDGyMPMsPGVAPVP X 3193; 2386; 3203 +Mapk3 ERK1 Q63844 mouse RREB1 68750 Q3UH06 Rreb1 mouse S970 4719142 AGQAEPLsPRPPPCP X +Mapk3 ERK1 Q63844 mouse Jun 16476 P05627 Jun mouse S73 447943 VGLLKLAsPELERLI Jun X 9164; 3270; 8752; 12714; 77955 +Mapk3 ERK1 Q63844 mouse GATA1 14460 P17679 Gata1 mouse S26 451232 VDSALVSsPSDSTGF X X +Mapk3 ERK1 Q63844 mouse FOXO1A 56458 Q9R1E0 Foxo1 mouse S326 448076 stISGRLsPIMtEQD X +Mapk3 ERK1 Q63844 mouse BIM 12125 O54918 Bcl2l11 mouse S55 454235 GDRCPHGsPQGPLAP X 4550 +Mapk3 ERK1 Q63844 mouse GJA1 14609 P23242 Gja1 mouse S282 448854 tAPLsPMsPPGykLV X +Mapk3 ERK1 Q63844 mouse p70S6K 6198 P23443 RPS6KB1 human S447 448357 GsPRtPVsPVkFsPG X 9204 +Mapk3 ERK1 Q63844 mouse ELK1 13712 P41969 Elk1 mouse S390 449757 LsPIAPRsPAKLSFQ X +Mapk3 ERK1 Q63844 mouse MAPKAPK2 17164 P49138 Mapkapk2 mouse T208 448269 TSHNsLttPCYtPYY Pkinase X 3316 +Mapk3 ERK1 Q63844 mouse ELK1 13712 P41969 Elk1 mouse T337 2751400 GGQGPERtPGSGTSS X +Mapk3 ERK1 Q63844 mouse ETV1 14009 P41164 Etv1 mouse S146 3059603 tPSStPVsPLHHASP ETS_PEA3_N X +Mapk3 ERK1 Q63844 mouse SYN3 8224 O14994 SYN3 human S470 455901 PQGQQPLsPQsGsPQ X +Mapk3 ERK1 Q63844 mouse GATA6 14465 Q61169 Gata6 mouse S264 2833503 ASARFPYsPSPPMAN GATA-N X +Mapk3 ERK1 Q63844 mouse ELK1 13712 P41969 Elk1 mouse S325 471887 RDLELPLsPSLLGGQ X +Mapk3 ERK1 Q63844 mouse AEBP1 11568 Q640N1 Aebp1 mouse T1003 455321 VDPSRPMtPQQRRMQ X +Mapk3 ERK1 Q63844 mouse ER-beta 13983 O08537 Esr2 mouse S87 447915 WPTSGHLsPLATHCQ ERbeta_N X +Mapk3 ERK1 Q63844 mouse STAR 20845 P51557 Star mouse S232 2089100 VLHPLAGsPSKTKLT START X X +Mapk3 ERK1 Q63844 mouse PXN 19303 Q8VI36 Pxn mouse S83 451113 yAHQQPPsPLPVyss Paxillin X +Mapk3 ERK1 Q63844 mouse ELK1 13712 P41969 Elk1 mouse S423 469193 LStPVVLsPGPQKP_ X +Mapk3 ERK1 Q63844 mouse RREB1 68750 Q3UH06 Rreb1 mouse S161 4719122 TTAAAPPsPLKRRRL X +Mapk3 ERK1 Q63844 mouse calponin 3 71994 Q9DAW9 Cnn3 mouse S293 4776192 QGtGTNGsEIsDsDy X +Mapk3 ERK1 Q63844 mouse ETV1 14009 P41164 Etv1 mouse T139 3059605 MRPSNPPtPSStPVs ETS_PEA3_N X +Mapk3 ERK1 Q63844 mouse ETV1 14009 P41164 Etv1 mouse T143 3059604 NPPtPSStPVsPLHH ETS_PEA3_N X +Mapk3 ERK1 Q63844 mouse STXBP1 20910 O08599 Stxbp1 mouse S241 36440508 DRGFDPSsPVLHELT Sec1 X X +Mapk3 ERK1 Q63844 mouse MAPKAPK2 17164 P49138 Mapkapk2 mouse T320 448273 QsTKVPQtPLHtsRV X 3007; 3041 +Mapk3 ERK1 Q63844 mouse GJA1 14609 P23242 Gja1 mouse S279 448853 SsPtAPLsPMsPPGy X +Mapk3 ERK1 Q63844 mouse PR 18667 Q00175 Pgr mouse S294 447987 SPIAPGRsPLATTVV Prog_receptor X 13736 +Mapk3 ERK1 Q63844 mouse MBP 618684 P02687 MBP cow T97 450929 KNIVtPRtPPPSQGK Myelin_MBP X +Mapk3 ERK1 Q63844 mouse TAL1 21349 P22091 Tal1 mouse S122 450663 DGRMVQLsPPALAAP X +Mapk3 ERK1 Q63844 mouse ETV1 14009 P41164 Etv1 mouse S94 3059606 KIKKEPHsPCSELGS ETS_PEA3_N X +Mapk3 ERK1 Q63844 mouse ER-beta 13983 O08537 Esr2 mouse S105 447914 LYAEPQKsPWCEARS ERbeta_N X +Mapk3 ERK1 Q63844 mouse ELK1 13712 P41969 Elk1 mouse S384 447872 IHFWSTLsPIAPRsP X X 9181; 9186 +Mapk3 ERK1 Q63844 mouse PPP1R1A 58200 Q9ERT9 Ppp1r1a mouse S67 447758 LKSTLsMsPRQRKKM DARPP-32 X +Mapk3 ERK1 Q63844 mouse Kv4.2 16508 Q9Z0V2 Kcnd2 mouse S616 457613 EGDDRPEsPEYsGGN X +Mapk3 ERK1 Q63844 mouse FOXO3A 56484 Q9WVH4 Foxo3 mouse S293 472326 QLSkWPGsPTSRssD X 5538 +Mapk3 ERK1 Q63844 mouse MEK1 26395 P31938 Map2k1 mouse T292 448287 EtPPRPRtPGRPLsS Pkinase X X 26975 +Mapk3 ERK1 Q63844 mouse KSR 16706 Q61097 Ksr1 mouse S443 449300 TTSSTPSsPAPFLTS X +Mapk3 ERK1 Q63844 mouse BIM 12125 O54918 Bcl2l11 mouse S65 449330 GPLAPPAsPGPFATR X 4581; 4585 +Mapk3 ERK1 Q63844 mouse p53 22059 P02340 Tp53 mouse S18 447490 IsLELPLsQEtFsGL P53_TAD X X 9284; 9286; 12571; 56979 +Mapk3 ERK1 Q63844 mouse PKCA 18750 P20444 Prkca mouse T638 448685 TRGQPVLtPPDQLVI Pkinase_C X X 9375 +Mapk3 ERK1 Q63844 mouse SRm300 75956 Q8BTI8 Srrm2 mouse S1068 453278 GsLsRsssPVtELtA X +Mapk3 ERK1 Q63844 mouse KLF4 16600 Q60793 Klf4 mouse S132 24976100 ASASSSSsPASSGPA X +Mapk3 ERK1 Q63844 mouse p90RSK 20111 P18653 Rps6ka1 mouse S369 447990 HQLFRGFsFVATGLM Pkinase_C X 9341; 9335; 13575; 11989; 12032; 75266; 93317; 13397; 13588 +Mapk3 ERK1 Q63844 mouse mGluR5 108071 Q3UVX5 Grm5 mouse S1158 25581600 LVALtPPsPFRDSVD GluR_Homer-bdg X +Mapk3 ERK1 Q63844 mouse Cofilin-1 12631 P18760 Cfl1 mouse T25 7990494 MkVRKSstPEEVKkR Cofilin_ADF X +Mapk3 ERK1 Q63844 mouse RANBP3 71810 Q9CT10 Ranbp3 mouse S58 460735 VKRERtssLtHsEEK X +Mapk3 ERK1 Q63844 mouse PXN 19303 Q8VI36 Pxn mouse S130 450228 KQksAEPsPtVMsss Paxillin X +Mapk3 ERK1 Q63844 mouse H3 iso3 15081 P84244 H3f3b mouse S28 455677 ATkAArksAPSTGGV Histone X 9713 +Mapk3 ERK1 Q63844 mouse Fos 314322 P12841 Fos rat T325 448483 TELEPLCtPVVTCtP X +Mapk3 ERK1 Q63844 mouse JunB 16477 P09450 Junb mouse S256 452631 RDAtPPVsPINMEDQ X +Mapk3 ERK1 Q63844 mouse Jun 16476 P05627 Jun mouse S63 447686 kNsDLLtsPDVGLLK Jun X 5464; 9261; 2361; 97721; 91952 +Mapk3 ERK1 Q63844 mouse EGR1 13653 P08046 Egr1 mouse S26 458492 PFGSFPHsPTMDNYP X +Mapk3 ERK1 Q63844 mouse STXBP1 20910 O08599 Stxbp1 mouse T574 454395 IGSTHILtPQKLLDt Sec1 X +Mapk3 ERK1 Q63844 mouse TACE 11491 Q9Z0F8 Adam17 mouse T735 449804 kPFPAPQtPGRLQAL X +Mapk3 ERK1 Q63844 mouse NFAT3 73181 Q8K120 Nfatc4 mouse S676 455348 SNGRRKRsPTQSFKF RHD_dimer X +Mapk3 ERK1 Q63844 mouse Bcl-2 12043 P10417 Bcl2 mouse S70 448395 RDMAARtsPLRPLVA X +Mapk3 ERK1 Q63844 mouse FAK 14083 P34152 Ptk2 mouse S910 447964 KLQPQEIsPPPTANL X +Mapk3 ERK1 Q63844 mouse STF-1 26423 P33242 Nr5a1 mouse S203 447603 EYPEPYAsPPQQPGP X +Mapk3 ERK1 Q63844 mouse ATF-2 11909 P16951 Atf2 mouse T53 448225 IVADQtPtPtRFLKN X X 9225; 9221; 5112; 94125; 13850; 40749; 15411; 24329; 61584; 27934; 92109; 20534; 35858 +Mapk3 ERK1 Q63844 mouse SHC1 20416 P98083 Shc1 mouse S36 448508 TPPEELPsPSASSLG X +Mapk3 ERK1 Q63844 mouse p70S6K 6198 P23443 RPS6KB1 human T444 448358 RFIGsPRtPVsPVkF X 9204 +Mapk3 ERK1 Q63844 mouse p70S6K 6198 P23443 RPS6KB1 human S434 448356 sFEPKIRsPRRFIGs X +Mapk3 ERK1 Q63844 mouse STMN1 16765 P54227 Stmn1 mouse S25 448555 QAFELILsPRskEsV Stathmin X +Mapk3 ERK1 Q63844 mouse C/EBP-beta 12608 P28033 Cebpb mouse T188 447878 sSssPPGtPSPADAK X X 3084 +Mapk3 ERK1 Q63844 mouse NOXA1 241275 Q8CJ00 Noxa1 mouse Y252 1869151102 GHTSPGLyDSLLASR X +Mapk3 ERK1 Q63844 mouse BIM 12125 O54918 Bcl2l11 mouse S100 449602 FSFDTDRsPAPMsCD X +Mapk3 ERK1 Q63844 mouse RCAN1 54720 Q9JHG6 Rcan1 mouse S165 456023 FLIsPPAsPPVGWKQ Calcipressin X +Mapk3 ERK1 Q63844 mouse PCYT1A 140544 P19836 Pcyt1a rat S315 451321 GRMLQAIsPKQsPss X +Mapk3 ERK1 Q63844 mouse NDEL1 83431 Q9ERR1 Ndel1 mouse T219 468252 ASLsLPAtPVGKGTE NUDE_C X +Mapk3 ERK1 Q63844 mouse ELK1 2002 P19419 ELK1 human S383 447872 IHFWSTLsPIAPRsP X 9181; 9186 +Mapk3 ERK1 Q63844 mouse MEK1 26395 P31938 Map2k1 mouse T386 448288 IGLNQPstPtHAASI X +Mapk3 ERK1 Q63844 mouse TH 25085 P04177 Th rat S31 448544 KQAEAVtsPRFIGRR TOH_N X 3370; 13041 +Mapk3 ERK1 Q63844 mouse PLA2G4A 18783 P47713 Pla2g4a mouse S505 447597 LNTSYPLsPLRDFss PLA2_B X 2831; 53044 +Mapk3 ERK1 Q63844 mouse MEK1 100009316 P29678 MAP2K1 rabbit T292 448287 ETPPRPRtPGRPLsS Pkinase X +Mapk3 ERK1 Q63844 mouse RSK2 110651 P18654 Rps6ka3 mouse S386 448065 HQLFRGFsFVAITSD Pkinase_C X 9341; 9335; 13575; 11989; 12032; 75266; 93317; 13397; 13588 +Mapk3 ERK1 Q63844 mouse Ets-2 23872 P15037 Ets2 mouse T72 447688 SCELPLLtPCSKAVM X +Mapk3 ERK1 Q63844 mouse Akt1 11651 P31750 Akt1 mouse T308 447856 KDGAtMKtFCGtPEy Pkinase X 5106; 2965; 9275; 4056; 5056; 13842; 13038; 43506; 48646; 86758; 80722; 77440; 80556 +Mapk3 ERK1 Q63844 mouse BIM 12125 O54918 Bcl2l11 mouse T112 449071 sCDKStQtPsPPCQA X +Mapk3 ERK1 Q63844 mouse STAT1 20846 P42225 Stat1 mouse S727 447753 tDNLLPMsPEEFDEM STAT1_TAZ2bind X 9177; 8826; 62390 +Mapk3 ERK1 Q63844 mouse TH 21823 P24529 Th mouse S31 448544 KQAEAVtsPRFIGRR TOH_N X 3370; 13041 +TGFBR1 TGFBR1 P36897 human p63 iso2 8626 Q9H3D4-2 TP63 human S68 451601 TFDALsPsPAIPSNT X X +TGFBR1 TGFBR1 P36897 human SMAD2 4087 Q15796 SMAD2 human S467 447495 sVRCssMs_______ X X 3108; 8828; 11979; 26945; 55041; 68550; 18338; 56532; 67804 +TGFBR1 TGFBR1 P36897 human ENG 2022 P17813 ENG human S646 12064201 StNHSIGsTQstPCS X +TGFBR1 TGFBR1 P36897 human p63 iso2 8626 Q9H3D4-2 TP63 human S66 451600 SSTFDALsPsPAIPS X X +TGFBR1 TGFBR1 P36897 human OTUB1 55611 Q96FW1 OTUB1 human S18 3072783 QEPLGsDsEGVNCLA X +TGFBR1 TGFBR1 P36897 human TGFBR3 7049 Q03167 TGFBR3 human S831 23940713 SPPASENsSAAHSIG X X +TGFBR1 TGFBR1 P36897 human SMAD2 4087 Q15796 SMAD2 human S465 447494 sPsVRCssMs_____ X X 3108; 8828; 11979; 26945; 55041; 68550; 18338; 56532; 67804 +TGFBR1 TGFBR1 P36897 human EEF1A1 1915 P68104 EEF1A1 human S300 15629200 EMHHEALsEALPGDN GTP_EFTU_D2 X X +TGFBR1 TGFBR1 P36897 human ENG 2022 P17813 ENG human S649 12064200 HSIGsTQstPCStSS X +TGFBR1 TGFBR1 P36897 human SMAD2 4087 Q15796 SMAD2 human S464 447567 GsPsVRCssMs____ X X +Rps6ka6 RSK4 NP_001178650 rat BSN 12217 O88737 Bsn mouse S2860 456576 KTLQRsLsDPKPLsP X +Rps6ka6 RSK4 NP_001178650 rat BSN 29138 O88778 Bsn rat S2845 456576 KTLQRSLsDPKPLSP X +AURKB AurB Q9N0X0 pig H3 8350 P68431 H3C1 human S10 455676 tkQtArkstGGkAPr Histone X 9701; 9711; 9606; 3465; 3642; 3377; 3475; 3458; 5764; 47398; 8481; 8552; 53348; 29237; 66065; 43185; 64522; 52725 +AURKB AurB Q9N0X0 pig AurB 396955 Q9N0X0 AURKB pig T232 450325 APSLRRKtMCGTLDY Pkinase X +MAP3K21 MLK4 Q5TCX8 human IL17RB 55540 Q9NRM6 IL17RB human Y447 5756439 LHKYVVVyFREIDTK SEFIR X +Stk38 NDR1 Q91VJ4 mouse PIK4CB iso2 5298 Q9UBF8-2 PI4KB human S277 457620 RTHQRSKsDATASIS X +Stk38 NDR1 Q91VJ4 mouse PANX2 406218 Q6IMP4 Panx2 mouse S514 25123901 KKHTRHFsLDVHPYI X +Stk38 NDR1 Q91VJ4 mouse YAP1 22601 P46938 Yap1 mouse S382 3190672 TyHSRDEstDsGLSM X 13619 +Stk38 NDR1 Q91VJ4 mouse RAB3IP 216363 Q68EF0 Rab3ip mouse S240 4734219 RGHTRNKsTSsAMGG Sec2p X +Stk38 NDR1 Q91VJ4 mouse RAB11FIP5 52055 Q8R361 Rab11fip5 mouse S307 456449 LTHKRtysDEAsQLR X +Stk38 NDR1 Q91VJ4 mouse AAK1 269774 Q3UHJ0 Aak1 mouse S635 467380 AGHRRILsDVtHsAV X 92438 +Stk38 NDR1 Q91VJ4 mouse NDR1 106504 Q91VJ4 Stk38 mouse S281 448828 NRRQLAFsTVGTPDy Pkinase X +Stk38 NDR1 Q91VJ4 mouse YAP1 22601 P46938 Yap1 mouse S112 448847 PQHVRAHssPAsLQL X 4911; 13008; 92367; 57706 +Sik1 SIK Q60670 mouse TORC3 70461 Q91X84 Crtc3 mouse S162 7101661 SALNRTNsDSALHTS TORC_M X +Sik1 SIK Q60670 mouse TORC3 70461 Q91X84 Crtc3 mouse S370 1210886 SLRLFsLsNPsLSTT X +Sik1 SIK Q60670 mouse SCARB1 25073 P97943 Scarb1 rat S496 14567809 AYSESLMsPAAkGTV X +Sik1 SIK Q60670 mouse PDE4D 238871 Q01063 Pde4d mouse S141 483645 SDsDyDLsPKSMSRN X X +Sik1 SIK Q60670 mouse TORC3 70461 Q91X84 Crtc3 mouse S62 3203139 LtQyHGGsLPNVSQL TORC_N X +Sik1 SIK Q60670 mouse TORC3 70461 Q91X84 Crtc3 mouse S329 468980 SGLQSsRsNPsIQAT X +Sik1 SIK Q60670 mouse PDE4D 238871 Q01063 Pde4d mouse S136 483644 sFLYRSDsDyDLsPK X X +Grk2 GRK2 Q99MK8 mouse IRS1 16367 P35569 Irs1 mouse S612 447562 DDGyMPMsPGVAPVP X 3193; 2386; 3203 +Grk2 GRK2 Q99MK8 mouse SMO 319757 P56726 Smo mouse T597 1872776116 ELSFsMHtVsHDGPV X +Grk2 GRK2 Q99MK8 mouse SMO 319757 P56726 Smo mouse S642 1872776120 AILPQDVsVtPVAtP X +Grk2 GRK2 Q99MK8 mouse KOR-1 18387 P33534 Oprk1 mouse T357 52467201 MRMERQstNRVRNtV X +Grk2 GRK2 Q99MK8 mouse SMO 319757 P56726 Smo mouse S599 1872776118 SFsMHtVsHDGPVAG X +Grk2 GRK2 Q99MK8 mouse MOR-1 18390 P42866 Oprm1 mouse T376 20727901 NtREHPstANtVDRT X +Grk2 GRK2 Q99MK8 mouse IRS1 16367 P35569 Irs1 mouse S635 447507 yMPMsPKsVsAPQQI X 2388 +Grk2 GRK2 Q99MK8 mouse KOR-1 18387 P33534 Oprk1 mouse S356 52467200 KMRMERQstNRVRNt X +Grk2 GRK2 Q99MK8 mouse ADRB2 11555 P18762 Adrb2 mouse S355 458916 KTYGNGYssNSNGRT X +Grk2 GRK2 Q99MK8 mouse ADRB2 11555 P18762 Adrb2 mouse S356 458917 TYGNGYssNSNGRTD X +Grk2 GRK2 Q99MK8 mouse PDE6G 18588 P09174 Pde6g mouse T62 449335 PGMEGLGtDITVICP PDE6_gamma X +Grk2 GRK2 Q99MK8 mouse PER2 18627 O54943 Per2 mouse S545 470015 sVAEMQssPPAQVKA X +Grk2 GRK2 Q99MK8 mouse SMO 319757 P56726 Smo mouse S560 1872776110 WCRLTGHsDDEPKRI X +Grk2 GRK2 Q99MK8 mouse SMO 319757 P56726 Smo mouse S594 1872776114 PGQELSFsMHtVsHD X +Grk2 GRK2 Q99MK8 mouse SMO 319757 P56726 Smo mouse T644 1872776122 LPQDVsVtPVAtPVP X +Grk2 GRK2 Q99MK8 mouse MOR-1 18390 P42866 Oprm1 mouse T370 447785 sARIRQNtREHPstA X +Grk2 GRK2 Q99MK8 mouse MOR-1 18390 P42866 Oprm1 mouse S375 447784 QNtREHPstANtVDR X 3451 +Grk2 GRK2 Q99MK8 mouse SMO 319757 P56726 Smo mouse T648 1872776124 VsVtPVAtPVPPEEQ X +Grk2 GRK2 Q99MK8 mouse MOR-1 18390 P42866 Oprm1 mouse T379 20727900 EHPstANtVDRTNHQ X +Notch2 Notch 2 O35516 mouse Akt1 11651 P31750 Akt1 mouse S473 447855 RPHFPQFsysAsGtA Pkinase_C X 9271; 3787; 4060; 4051; 5102; 4058; 2336; 2337; 4075; 4070; 5012; 4071; 92982; 5315; 9563; 9018; 12694; 52240; 11962; 15116; 88106; 26580; 68035; 31957; 23430; 20235 +Notch2 Notch 2 O35516 mouse Akt1 11651 P31750 Akt1 mouse T308 447856 KDGAtMKtFCGtPEy Pkinase X 5106; 2965; 9275; 4056; 5056; 13842; 13038; 43506; 48646; 86758; 80722; 77440; 80556 +Gsk3a GSK3A P18265 rat PPAR-alpha 5465 Q07869 PPARA human S280 1867858200 FHCCQCTsVETVTEL Hormone_recep X +Gsk3a GSK3A P18265 rat PPP1R2 100009520 P11845 PPP1R2 rabbit T73 449051 MKIDEPStPYHSMIG IPP-2 X +Gsk3a GSK3A P18265 rat MAP2 iso2 25595 P15146-2 Map2 rat S136 448323 ETVNLPPsPPPSPAS X 4541 +Gsk3a GSK3A P18265 rat ACLY 24159 P16638 Acly rat T446 455371 NASGSTStPAPsRtA X +Gsk3a GSK3A P18265 rat eIF2B-epsilon 192234 Q64350 Eif2b5 rat S535 449905 VDPEELDsRAGsPQL X +Gsk3a GSK3A P18265 rat CREB iso1 81646 P15337-1 Creb1 rat S133 448228 EILsRRPsYRkILND pKID X 9187; 9196; 9198; 4095; 14228; 14001; 39561; 80120; 44864; 54960; 95995 +Gsk3a GSK3A P18265 rat MAP2 25595 P15146 Map2 rat S136 448323 ETVNLPPsPPPsPAS X 4541 +Gsk3a GSK3A P18265 rat PXN 360820 Q66H76 Pxn rat S126 450227 SFPNKQKsAEPsPtV Paxillin X +Gsk3a GSK3A P18265 rat CRMP-4 25418 Q62952 Dpysl3 rat T509 454328 PVFDLTTtPKGGtPA X +Gsk3a GSK3A P18265 rat CRMP-2 25416 P47942 Dpysl2 rat T514 454386 SVtPKTVtPASsAKT X 9397 +Gsk3a GSK3A P18265 rat CREB iso1 81646 P15337-1 Creb1 rat S129 450092 QKRREILsRRPsYRk pKID X +Gsk3a GSK3A P18265 rat MAP2 iso3 25595 P15146-3 Map2 rat S136 448323 ETVNLPPsPPPSPAS X 4541 +Gsk3a GSK3A P18265 rat MAP2 25595 P15146 Map2 rat T1622 450181 YSSRtPGtPGtPSyP X 4544 +Gsk3a GSK3A P18265 rat ACLY 24159 P16638 Acly rat S450 455372 STStPAPsRtAsFSE X +Gsk3a GSK3A P18265 rat MAP2 25595 P15146 Map2 rat T1625 450182 RtPGtPGtPSyPRTP X 4544 +Gsk3a GSK3A P18265 rat CRMP-2 25416 P47942 Dpysl2 rat T509 448083 PVCEVSVtPKTVtPA X +MAPKAPK5 MAPKAPK5 Q8IW41 human SEPT8 23176 Q92599 SEPTIN8 human S192 25538006 IAKADTIskSELHkF Septin X +MAPKAPK5 MAPKAPK5 Q8IW41 human p53 7157 P04637 TP53 human S37 447532 NVLsPLPsQAMDDLM TAD2 X X 9289 +MAPKAPK5 MAPKAPK5 Q8IW41 human NRF2 4780 Q16236 NFE2L2 human S558 10292703 HLLkkQLstLyLEVF bZIP_Maf X +MAPKAPK5 MAPKAPK5 Q8IW41 human RHEB 6009 Q15382 RHEB human S130 18157800 LHMERVIsYEEGkAL Ras X +MAPKAPK5 MAPKAPK5 Q8IW41 human TH iso3 7054 P07101-3 TH human S19 448542 KGFRRAVsELDAKQA TOH_N X +MAPKAPK5 MAPKAPK5 Q8IW41 human TH iso3 7054 P07101-3 TH human S404 10348000 GELLHCLsEEPEIRA Biopterin_H X +MAPKAPK5 MAPKAPK5 Q8IW41 human TH 7054 P07101 TH human S19 448542 KGFRRAVsELDAKQA TOH_N X +MAPKAPK5 MAPKAPK5 Q8IW41 human kalirin 8997 O60229 KALRN human S487 472573 DVLQRPLsPGNSESL X +MAPKAPK5 MAPKAPK5 Q8IW41 human HSP40 3337 P25685 DNAJB1 human S171 30306602 VTHDLRVsLEEIysG DnaJ_C X X +MAPKAPK5 MAPKAPK5 Q8IW41 human SEPT8 23176 Q92599 SEPTIN8 human S163 25538007 FITPTGHsLKSLDLV Septin X +MAPKAPK5 MAPKAPK5 Q8IW41 human HSP40 3337 P25685 DNAJB1 human S151 23099871 VNFGRsRsAQEPARK X X +MAPKAPK5 MAPKAPK5 Q8IW41 human HSP40 3337 P25685 DNAJB1 human S149 30306601 TNVNFGRsRsAQEPA X X +MAPKAPK5 MAPKAPK5 Q8IW41 human TH iso3 7054 P07101-3 TH human S40 448545 RFIGRRQsLIEDARK TOH_N X 2791 +DAPK2 DAPK2 Q9UIK4 human DAPK2 23604 Q9UIK4 DAPK2 human S318 450028 VRRRWKLsFsIVSLC X +DAPK2 DAPK2 Q9UIK4 human Raptor 57521 Q8N122 RPTOR human S721 4206802 tPrLrsVssyGNIRA X X +DAPK2 DAPK2 Q9UIK4 human Tau iso8 4137 P10636-8 MAPT human S214 447929 GsRsRtPsLPtPPtR X 77348 +Map3k5 ASK1 O35099 mouse CLOCK 12753 O08785 Clock mouse S845 23094535 LPRHRtDsLTDPSKV X +Map3k5 ASK1 O35099 mouse P2Y12 70839 Q9CPV9 P2ry12 mouse T345 138970300 GGEPsEEtPM_____ X +Map3k5 ASK1 O35099 mouse CLOCK 12753 O08785 Clock mouse T843 941453100 QQLPRHRtDsLTDPS X +Map3k5 ASK1 O35099 mouse ASK1 26408 O35099 Map3k5 mouse T845 448394 GINPCtEtFTGtLQY Pkinase X X 3765 +Mapk14 P38A P70618 rat Kv2.1 25736 P15387 Kcnb1 rat S804 473562 ESsPLPTsPKFLRPN X +Mapk14 P38A P70618 rat Bcl-2 24224 P49950 Bcl2 rat S70 448395 RDTAARTsPLRPLVA X +Mapk14 P38A P70618 rat BIM 64547 O88498 Bcl2l11 rat S65 449330 GPLAPPAsPGPFATR X 4581; 4585 +PRKCH PKCH P24723 human ITGB2 3689 P05107 ITGB2 human S745 448532 FEkEKLksQWNNDNP Integrin_b_cyt X +PRKCH PKCH P24723 human SHP-2 5781 Q06124 PTPN11 human S591 469623 GLMQQQksFR_____ X +PRKCH PKCH P24723 human ITGB2 3689 P05107 ITGB2 human T758 448533 NPLFksAtttVMNPk Integrin_b_cyt X +PRKCH PKCH P24723 human SHP-2 5781 Q06124 PTPN11 human S576 469622 CAEMREDsARVyENV X +PRKCH PKCH P24723 human GSK3A 606496 Q2NL51 Gsk3a mouse S21 448584 sGRARtssFAEPGGG X 9337; 9316; 9331; 9327; 8452; 8566 +PRKCH PKCH P24723 human GSK3B 56637 Q9WV60 Gsk3b mouse S9 449111 SGRPRttsFAEsCKP X 9336; 9331; 9327; 9323; 9322; 9325; 5558; 8566; 79774; 8466; 25462; 14026; 14332; 14310; 14630 +PRKCH PKCH P24723 human PKCH 5583 P24723 PRKCH human S32 3074800 tRWsLRHsLFKkGHQ C2 X +PRKCH PKCH P24723 human mGluR5 24418 P31424 Grm5 rat S839 455778 VRSAFTTstVVRMHV X +PRKCH PKCH P24723 human PRKD2 25865 Q9BZL6 PRKD2 human S706 449864 ARIIGEksFRRsVVG Pkinase X +PRKCH PKCH P24723 human PRKD2 25865 Q9BZL6 PRKD2 human S710 449865 GEksFRRsVVGtPAy Pkinase X +PRKCH PKCH P24723 human GSK3A 2931 P49840 GSK3A human S21 448584 sGrARtssFAEPGGG X X 9337; 9316; 9331; 5090; 9327; 8452; 8566 +PRKCH PKCH P24723 human GSK3B 2932 P49841 GSK3B human S9 449111 SGRPRttsFAEsCkP X X 9336; 9331; 9327; 9323; 9322; 9325; 5558; 8566; 79774; 8466; 25462; 14026; 14332; 14310; 14630 +PRKCH PKCH P24723 human PKCH 5583 P24723 PRKCH human S28 3074801 GLQPtRWsLRHsLFK C2 X +PRKCH PKCH P24723 human PRKD1 5587 Q15139 PRKD1 human S738 448589 ARIIGEksFRRsVVG Pkinase X X 2054 +PRKCH PKCH P24723 human AID 11628 Q9WVE0 Aicda mouse T140 6835300 GVQIGIMtFKDYFYC APOBEC2 X +PRKCH PKCH P24723 human PRKD2 25865 Q9BZL6 PRKD2 human S876 448800 QGLAERIsVL_____ X +PRKCH PKCH P24723 human GSTP1 2950 P09211 GSTP1 human S185 455118 SAYVGRLsARPkLkA GST_C_3 X +PRKCH PKCH P24723 human PRKD1 5587 Q15139 PRKD1 human S742 448590 GEksFRRsVVGtPAy Pkinase X X +PRKCH PKCH P24723 human GSTP1 2950 P09211 GSTP1 human S43 455117 VETWQEGsLkAsCLy GST_N X +PLK1 PLK1 P53350 human dynactin 1 1639 Q14203 DCTN1 human S179 15512801 sASAGELsSSEPSTP X X +PLK1 PLK1 P53350 human CCNT1 904 O60563 CCNT1 human S564 28735106 KTYSLSSsFSSSSsT X +PLK1 PLK1 P53350 human Nlp 22981 Q9Y2I6 NINL human S88 451061 RPSDEDssSLESAAS X +PLK1 PLK1 P53350 human PTEN 5728 P60484 PTEN human S380 448313 EPDHyRYsDttDsDP X X 9551; 9554; 9549; 7960 +PLK1 PLK1 P53350 human PINX1 54984 Q96BK5 PINX1 human S226 14823405 ATGKDVEsyLQPkAK X X +PLK1 PLK1 P53350 human CLASP2 23122 O75122 CLASP2 human S1092 27434506 MKLtQEEsFSVWDEH X X +PLK1 PLK1 P53350 human APC1 64682 Q9H1A4 ANAPC1 human T520 455828 GLPAPsLtMsNtMPR X +PLK1 PLK1 P53350 human SynGAP iso3 192117 Q9QUH6-3 Syngap1 rat S777 18710208 EPEQKMLsVNKsVsM DUF3498 X +PLK1 PLK1 P53350 human MAP9 79884 Q49MG5 MAP9 human S289 15105800 SDENKENsFsADHVT X X +PLK1 PLK1 P53350 human PCNT 5116 O95613 PCNT human T1221 25617503 ALPELDRtLSECAEM X +PLK1 PLK1 P53350 human CDC25C 995 P30307 CDC25C human S75 125104500 PkRCLDLsNLSSGEI X +PLK1 PLK1 P53350 human PRC1 9055 O43663 PRC1 human T616 7444691 TSGILNstNIQs___ X +PLK1 PLK1 P53350 human KIF2C 11004 Q99661 KIF2C human S715 3545002 MQLEEQAsRQIsSKK X +PLK1 PLK1 P53350 human MLL5 55904 Q8IZD2 KMT2E human S861 54363512 sPLLLNDsCSLPDLT X +PLK1 PLK1 P53350 human MAD1L1 8379 Q9Y6D9 MAD1L1 human T680 5024706 SKMQLLEtEFSHTVG MAD X +PLK1 PLK1 P53350 human MDC1 9656 Q14676 MDC1 human S20 63083900 EEEEtEQssESLRCN X +PLK1 PLK1 P53350 human VCP 7415 P55072 VCP human T76 1876872800 CIVLsDDtCSDEkIR CDC48_N X X +PLK1 PLK1 P53350 human CDC27 996 P30260 CDC27 human T209 455849 LtEtPQDtIELNRLN X +PLK1 PLK1 P53350 human BORA 79866 Q6PGQ7 BORA human S497 2512942 SSNIQMDsGYNtQNC X +PLK1 PLK1 P53350 human SGO1 72415 Q9CXH7 Sgo1 mouse T146 2535905 QQIAVEEtDCPYQTT X +PLK1 PLK1 P53350 human TNKS 8658 O95271 TNKS human T982 471334 SLIsPAStPSCLsAA X X +PLK1 PLK1 P53350 human CASC5 iso2 57082 Q8NG31-2 KNL1 human T875 40560200 DKNDMDItKSYTIEI MELT X X +PLK1 PLK1 P53350 human TTK 7272 P33981 TTK human T46 41389704 NKISADttDNsGTVN X +PLK1 PLK1 P53350 human CENPQ 55166 Q7L2Z9 CENPQ human T123 40245503 RLLQQCEtLKVPPKk CENP-Q X X +PLK1 PLK1 P53350 human PCNT 5116 O95613 PCNT human T1209 25617502 TAPALEEtWSDVALP X +PLK1 PLK1 P53350 human NDR1 11329 Q15208 STK38 human T407 41425401 EIKSIDDtSNFDEFP Pkinase_C X X +PLK1 PLK1 P53350 human SAPS2 9701 O75170 PPP6R2 human T10 1109469503 WKFDLNTtSHVDkLL X +PLK1 PLK1 P53350 human NDR1 11329 Q15208 STK38 human T7 22553317 _MAMtGstPCssMsN X X +PLK1 PLK1 P53350 human ROCK2 282041 Q28021 ROCK2 cow S1133 1732200 LHIGLDSsSIGSGPG X +PLK1 PLK1 P53350 human CDC20 991 Q12834 CDC20 human S170 23092094 KtCRYIPsLPDrILD X X +PLK1 PLK1 P53350 human TOP2A 7153 P11388 TOP2A human T1343 448763 FsDFDEKtDDEDFVP X +PLK1 PLK1 P53350 human TTK 7272 P33981 TTK human T33 2846502 kFkNEDLtDELsLNK X +PLK1 PLK1 P53350 human NEDD1 121441 Q8NHV4 NEDD1 human S637 9379000 HSLLERysVNEGLVA X +PLK1 PLK1 P53350 human TOP2A 7153 P11388 TOP2A human S1525 448764 PIKyLEEsDEDDLF_ X X +PLK1 PLK1 P53350 human CDC16 8881 Q13042 CDC16 human S112 455864 EkYLkDEsGFkDPSS X +PLK1 PLK1 P53350 human KIF2B 84643 Q8N4N8 KIF2B human T125 25247520 MIPQKNQtAsGDsLD X X +PLK1 PLK1 P53350 human HSP70 3303 P0DMV8 HSPA1B human S633 18010650 GPkGGsGsGPtIEEV X +PLK1 PLK1 P53350 human DVL2 1856 O14641 DVL2 human T206 17301000 MTSELEStSLGDsDE Dishevelled X X +PLK1 PLK1 P53350 human CLASP2 23122 O75122 CLASP2 human S1053 14159685 DQFPDDLsLDHsDLV X X +PLK1 PLK1 P53350 human PTP1B 5770 P18031 PTPN1 human S393 9765677 sPAKGEPsLPEKDED X +PLK1 PLK1 P53350 human MDM2 4193 Q00987 MDM2 human S260 454923 sLDsEDYsLsEEGQE X X +PLK1 PLK1 P53350 human hnRNP U 3192 Q00839 HNRNPU human S59 468001 AMEPGNGsLDLGGDs X X +PLK1 PLK1 P53350 human TOPORS 10210 Q9NS56 TOPORS human S718 5938002 kDRDGYEsSYRRRTL X X +PLK1 PLK1 P53350 human CENPQ 55166 Q7L2Z9 CENPQ human S138 18007846 MEDLtNVssLLNMER CENP-Q X X +PLK1 PLK1 P53350 human CTNNB1 1499 P35222 CTNNB1 human S311 1881000308 LAYGNQEsKLIILAS X X +PLK1 PLK1 P53350 human TTK 7272 P33981 TTK human T594 41389700 RLYDYEItDQYIYMV Pkinase X +PLK1 PLK1 P53350 human KLF4 9314 O43474 KLF4 human S234 31081924 GkFVLkAsLsAPGSE X X +PLK1 PLK1 P53350 human SynGAP iso3 192117 Q9QUH6-3 Syngap1 rat S836 4792755 AGRLSQGsGSSITAA DUF3498 X +PLK1 PLK1 P53350 human RASGRF1 192213 P28818 Rasgrf1 rat S575 18710202 QEKAAWTsDIIQCVD PH X +PLK1 PLK1 P53350 human CENPQ 55166 Q7L2Z9 CENPQ human T256 40245502 sQMKsMstFIEEAYK CENP-Q X X +PLK1 PLK1 P53350 human TTK 7272 P33981 TTK human S321 3189826 SkPsGNDsCELRNLk X +PLK1 PLK1 P53350 human BRCA1 672 P38398 BRCA1 human S1164 36135579 GEIKEDTsFAENDIk X X +PLK1 PLK1 P53350 human APC1 64682 Q9H1A4 ANAPC1 human S377 455827 NIssHNQsPkRHSIS X +PLK1 PLK1 P53350 human MST2 6788 Q13188 STK3 human T384 3195191 GtMKRNAtsPQVQRP X +PLK1 PLK1 P53350 human SynGAP iso3 192117 Q9QUH6-3 Syngap1 rat S326 4792707 GsGGGGGsGGGSGGK X +PLK1 PLK1 P53350 human LRRK1 79705 Q38SD2 LRRK1 human S1817 41694201 GDSIADVsIMYSEEL X X +PLK1 PLK1 P53350 human TTK 7272 P33981 TTK human S108 41389701 DkYGQNEsFARIQVR X +PLK1 PLK1 P53350 human CENPQ 55166 Q7L2Z9 CENPQ human S253 23092802 HNssQMKsMstFIEE CENP-Q X X +PLK1 PLK1 P53350 human APC7 51434 Q9UJX3 ANAPC7 human S23 455842 HsNVRLLssLLLtMs X +PLK1 PLK1 P53350 human TTK 7272 P33981 TTK human T458 15428764 CktPsSNtLDDyMsC X +PLK1 PLK1 P53350 human CEP68 23177 Q76N32 CEP68 human S332 37046602 ADPVLQDsGVDLDSF X X +PLK1 PLK1 P53350 human PPP1R7 5510 Q15435 PPP1R7 human S44 468497 sGIVADLsEQsLkDG X +PLK1 PLK1 P53350 human TTK 7272 P33981 TTK human T12 13194901 DLsGRELtIDsIMNk X +PLK1 PLK1 P53350 human NFL 18039 P08551 Nefl mouse S473 450895 EAKDEPPsEGEAEEE X +PLK1 PLK1 P53350 human NEDD1 121441 Q8NHV4 NEDD1 human S426 9379002 VNKGsDEsIGkGDGF X +PLK1 PLK1 P53350 human TTK 7272 P33981 TTK human S333 41389702 NLkSVQNsHFkEPLV X +PLK1 PLK1 P53350 human MAD1L1 8379 Q9Y6D9 MAD1L1 human S22 5024704 RsLNNFIsQRVEGGs X +PLK1 PLK1 P53350 human PPP1R7 5510 Q15435 PPP1R7 human S27 465871 RRVEsEEsGDEEGKk X +PLK1 PLK1 P53350 human CASP8 841 Q14790 CASP8 human S305 31894302 IYQLMDHsNMDCFIC Peptidase_C14 X X +PLK1 PLK1 P53350 human USP16 10600 Q9Y5T5 USP16 human S386 50592104 HESFLDLsLPVLDDQ UCH X X +PLK1 PLK1 P53350 human NCAPH2 29781 Q6IBW4 NCAPH2 human S288 36136891 EsRsPQQsAALPRRY X X +PLK1 PLK1 P53350 human PPP1R7 5510 Q15435 PPP1R7 human S24 465870 EVDRRVEsEEsGDEE X +PLK1 PLK1 P53350 human FOXM1 2305 Q08050 FOXM1 human S739 18009877 SKILLDIsFPGLDED X X +PLK1 PLK1 P53350 human DYNC1I2 116659 Q62871 Dync1i2 rat T95 469264 PssKSVstPsEAGsQ X +PLK1 PLK1 P53350 human Vimentin 22352 P20152 Vim mouse S83 451816 GVRLLQDsVdFsLAD Filament_head X X 3878; 12569 +PLK1 PLK1 P53350 human MEK1 5604 Q02750 MAP2K1 human S222 448513 LIDsMANsFVGtRSY Pkinase X 2338; 9121; 3958; 9154; 16211; 86128; 16780; 75262 +PLK1 PLK1 P53350 human PCNT 5116 O95613 PCNT human S1235 25617500 MSSVAEIsSHMREsF X +PLK1 PLK1 P53350 human PRC1 9055 O43663 PRC1 human S615 4274308 ATSGILNstNIQs__ X +PLK1 PLK1 P53350 human CDC6 990 Q99741 CDC6 human T37 17481900 SDAkLEPtNVQTVtC X X +PLK1 PLK1 P53350 human CENPQ 55166 Q7L2Z9 CENPQ human S249 3850352 LDILHNssQMKsMst CENP-Q X X +PLK1 PLK1 P53350 human Vimentin 7431 P08670 VIM human T336 31863396 EVdALkGtNEsLERQ Filament X +PLK1 PLK1 P53350 human CCNB1 891 P14635 CCNB1 human S126 448814 PILVDTAsPsPMETs X X +PLK1 PLK1 P53350 human MgcRacGAP 29127 Q9H0H5 RACGAP1 human S164 459864 sFDKtDEsLDWDssL X X +PLK1 PLK1 P53350 human FOXM1 iso2 2305 Q08050-2 FOXM1 human S724 18009877 SKILLDIsFPGLDED X X +PLK1 PLK1 P53350 human NCAPD3 23310 P42695 NCAPD3 human S1419 19009802 AIstPEKsISDVtFG X X +PLK1 PLK1 P53350 human TTK 7272 P33981 TTK human S291 31862439 CDVktDDsVVPCFMK X +PLK1 PLK1 P53350 human PAX3-FOXO1 2308 AAC50053 PAX3/FOXO1 human S503 37038800 PRTSSNAsTISGRLs X X +PLK1 PLK1 P53350 human axin 2 8313 Q9Y2T1 AXIN2 human S311 53439300 SDALTDDsMSMTDSS X X +PLK1 PLK1 P53350 human RAD21 5885 O60216 RAD21 human S175 474523 REIMREGsAFEDDDM X +PLK1 PLK1 P53350 human MDC1 9656 Q14676 MDC1 human T4 3965656 ____MEDtQAIDWDV X X +PLK1 PLK1 P53350 human TTK 7272 P33981 TTK human T371 1737600 LLAkLEEtkEyQEPE X +PLK1 PLK1 P53350 human CELSR1 12614 O35161 Celsr1 mouse S2741 27446069 KKLQLDDsATTRATL X +PLK1 PLK1 P53350 human BRCA2 675 P51587 BRCA2 human S205 469575 LATPPtLsstVLIVR X +PLK1 PLK1 P53350 human GTF3B 2972 Q92994 BRF1 human S450 3208533 GDGELDLsGIDDLEI BRF1 X +PLK1 PLK1 P53350 human TNKS 8658 O95271 TNKS human T930 21326700 LAHGADPtMkNQEGQ Ank_5 X X +PLK1 PLK1 P53350 human YY1 7528 P25490 YY1 human T39 18264901 PVETIETtVVGEEEE X X +PLK1 PLK1 P53350 human WDCP 80304 Q9H6R7 WDCP human S686 3212568 RsDVFRDsFsHsPGA X X +PLK1 PLK1 P53350 human RASGRF1 192213 P28818 Rasgrf1 rat S760 18710206 LASLGCPsDGYTNIH X +PLK1 PLK1 P53350 human CDC25B 994 P30305 CDC25B human S465 20503411 PLERDAEsFLLksPI Rhodanese X +PLK1 PLK1 P53350 human NuaK1 9891 O60285 NUAK1 human S480 33406501 QREsGYYsSPERSES X +PLK1 PLK1 P53350 human 53BP1 7158 Q12888 TP53BP1 human S1618 3194894 LtkAADIsLDNLVEG X X 6209 +PLK1 PLK1 P53350 human Vimentin 7431 P08670 VIM human S83 451816 GVRLLQDsVdFsLAd Filament_head X X 3878; 12569 +PLK1 PLK1 P53350 human CDC23 8697 Q9UJX2 CDC23 human T562 454344 QLRNQGEtPttEVPA X +PLK1 PLK1 P53350 human SUZ12 23512 Q15022 SUZ12 human S539 4746706 RPKRTkAsMsEFLEs X +PLK1 PLK1 P53350 human MEK1 5604 Q02750 MAP2K1 human S218 448514 VsGQLIDsMANsFVG Pkinase X 9121; 3958; 9154; 86128 +PLK1 PLK1 P53350 human BRCA2 675 P51587 BRCA2 human S193 469574 AEVDPDMsWSSSLAT X X +PLK1 PLK1 P53350 human MST2 6788 Q13188 STK3 human S15 4272103 KSKLKkLsEDsLTkQ X X +PLK1 PLK1 P53350 human CENPU 79682 Q71F23 CENPU human S77 471407 TFDPPLHstAIyADE X X +PLK1 PLK1 P53350 human CDC27 996 P30260 CDC27 human T430 455860 INDsLEItkLDssII X +PLK1 PLK1 P53350 human Chk2 11200 O96017 CHEK2 human T205 12473001 VFVFFDLtVDDQsVY X +PLK1 PLK1 P53350 human KIF2C 11004 Q99661 KIF2C human S632 5829783 EELSsQMssFNEAMT X +PLK1 PLK1 P53350 human Wee1 7465 P30291 WEE1 human S53 451131 GHstGEDsAFQEPDS X +PLK1 PLK1 P53350 human Vimentin 7431 P08670 VIM human S459 470128 GQVINEtsQHHDDLE X X +PLK1 PLK1 P53350 human LSD1 23028 O60341 KDM1A human S126 3175618 EYREMDEsLANLsED X X +PLK1 PLK1 P53350 human CDC23 8697 Q9UJX2 CDC23 human T565 455847 NQGEtPttEVPAPFF X +PLK1 PLK1 P53350 human TTK 7272 P33981 TTK human T676 487540 NQMQPDttsVVkDSQ Pkinase X X +PLK1 PLK1 P53350 human RIOK2 55781 Q9BVS4 RIOK2 human S548 21241902 KSSLEAAsFWGE___ X X +PLK1 PLK1 P53350 human RAPGEF2 iso2 9693 Q17RH5 RAPGEF2 human S794 18710214 RECKNFNsMFAIISG RasGEF X +PLK1 PLK1 P53350 human CELSR1 12614 O35161 Celsr1 mouse S2752 31884511 RATLLtRsLNCNNTY X +PLK1 PLK1 P53350 human DZIP1 66573 Q8BMD2 Dzip1 mouse S210 62403301 QRRHTEDsHLEYNTK X +PLK1 PLK1 P53350 human p73 7161 O15350 TP73 human T27 2063601 SSLEPDStyFDLPQS X X +PLK1 PLK1 P53350 human TSC1 7248 Q92574 TSC1 human S579 911089200 CQTSLETsIFTPsPC Hamartin X X +PLK1 PLK1 P53350 human RUVBL1 8607 Q9Y265 RUVBL1 human T239 41608704 kEIIQDVtLHDLDVA TIP49 X +PLK1 PLK1 P53350 human CEP55 55165 Q53EZ4 CEP55 human S436 457630 PtAALNEsLVECPkC X X +PLK1 PLK1 P53350 human SynGAP iso3 192117 Q9QUH6-3 Syngap1 rat S320 4792701 GGSGGMGsGGGGGsG X X +PLK1 PLK1 P53350 human CDC25B 994 P30305 CDC25B human S375 455380 ARVLRsksLCHDEIE M-inducer_phosp X +PLK1 PLK1 P53350 human NDR1 11329 Q15208 STK38 human T183 41425402 TLLMKKDtLTEEETQ Pkinase X X +PLK1 PLK1 P53350 human MgcRacGAP 29127 Q9H0H5 RACGAP1 human T260 7652108 QPWNsDstLNSRQLE X +PLK1 PLK1 P53350 human Bcl-xL 598 Q07817 BCL2L1 human S62 449099 PSWHLADsPAVNGAT X +PLK1 PLK1 P53350 human TRF1 7013 P54274 TERF1 human S435 3192037 KKLKLIssDsED___ X X +PLK1 PLK1 P53350 human PICH 54821 Q2NKX8 ERCC6L human T1063 474544 VKQFDAstPkNDIsP X X +PLK1 PLK1 P53350 human NUDC 10726 Q9Y266 NUDC human S326 451057 QHPEMDFskAkFN__ X X +PLK1 PLK1 P53350 human Vimentin 7431 P08670 VIM human T327 3180351 RRQVQsLtCEVdALk Filament X X +PLK1 PLK1 P53350 human CCDC141 545428 E9Q8Q6 Ccdc141 mouse T91 1874043200 LLREADRtAEANKAQ X +PLK1 PLK1 P53350 human KIF23 71819 E9Q5G3 Kif23 mouse S905 459841 GSRKRRsstLAPAQP X +PLK1 PLK1 P53350 human SNCB 6620 Q16143 SNCB human S118 448525 LMEPEGEsYEDPPQE Synuclein X X +PLK1 PLK1 P53350 human SGO1 72415 Q9CXH7 Sgo1 mouse S73 2535906 LALENEKsKVREAQD X +PLK1 PLK1 P53350 human TNKS 8658 O95271 TNKS human T839 21326702 DTQGRNStPLHLAAG Ank_4 X X +PLK1 PLK1 P53350 human Kizuna 55857 Q2M2Z5 KIZ human T379 469605 WSTSSDLtISISEDD X X +PLK1 PLK1 P53350 human BRCA2 675 P51587 BRCA2 human S206 469576 ATPPtLsstVLIVRN X +PLK1 PLK1 P53350 human RAPGEF2 iso2 9693 Q17RH5 RAPGEF2 human S1164 18710215 DERRQRHsVSIVETN X +PLK1 PLK1 P53350 human CtIP 5932 Q99708 RBBP8 human T693 1868101003 ETVDMDCtLVSETVL X +PLK1 PLK1 P53350 human FBX5 67141 Q7TSG3 Fbxo5 mouse S124 456211 ASRLYEDsGYSsFTQ X +PLK1 PLK1 P53350 human PINX1 54984 Q96BK5 PINX1 human S110 14823406 SDKKEKKsFSLEEKs X X +PLK1 PLK1 P53350 human FBX5 67141 Q7TSG3 Fbxo5 mouse S128 456212 YEDsGYSsFTQSDRD X +PLK1 PLK1 P53350 human SUZ12 23512 Q15022 SUZ12 human S546 449173 sMsEFLEsEDGEVEQ VEFS-Box X +PLK1 PLK1 P53350 human MAD1L1 8379 Q9Y6D9 MAD1L1 human S29 5024705 sQRVEGGsGLDISTS X +PLK1 PLK1 P53350 human CELSR1 12614 O35161 Celsr1 mouse T2750 41159600 TTRATLLtRsLNCNN X +PLK1 PLK1 P53350 human HSF1 3297 Q00613 HSF1 human S419 455264 SALLDLFsPSVTVPD Vert_HS_TF X +PLK1 PLK1 P53350 human MEK2 5605 P36507 MAP2K2 human S222 448073 VsGQLIDsMANsFVG Pkinase X 9121; 3958; 9154; 86128 +PLK1 PLK1 P53350 human SUGT1 67955 Q9CX34 Sugt1 mouse S302 18016406 VKRAMNKsFMESGGT SGS X X +PLK1 PLK1 P53350 human Nlp 22981 Q9Y2I6 NINL human S87 451060 VRPSDEDssSLESAA X +PLK1 PLK1 P53350 human CDC25B 994 P30305 CDC25B human S397 20503409 RELIGDYskAFLLQt X +PLK1 PLK1 P53350 human RAPGEF2 iso2 9693 Q17RH5 RAPGEF2 human S921 4737718 KKWRSLGsLSQGSTN X +PLK1 PLK1 P53350 human PPP1R7 5510 Q15435 PPP1R7 human T277 57812709 LENNNKLtMLDIASN LRR_9 X +PLK1 PLK1 P53350 human CLASP2 23122 O75122 CLASP2 human S1027 7320226 NPyNysDsIsPFNKs X X +PLK1 PLK1 P53350 human Restin 6249 P30622 CLIP1 human S195 468616 LtKtAsEsIsNLsEA X X +PLK1 PLK1 P53350 human CDC27 996 P30260 CDC27 human S435 455862 EItkLDssIIsEGkI X +PLK1 PLK1 P53350 human YAP1 10413 P46937 YAP1 human T77 126835301 NAVMNPktANVPQtV X +PLK1 PLK1 P53350 human TEX14 56155 Q8IWB6 TEX14 human S437 25158900 QKAATVKsDIYSFSM PK_Tyr_Ser-Thr X +PLK1 PLK1 P53350 human CCNB1 891 P14635 CCNB1 human S147 448446 EDLCQAFsDVILAVN X X 4131 +PLK1 PLK1 P53350 human SNCA 6622 P37840 SNCA human S129 448278 NEAyEMPsEEGyQDy Synuclein X X 23706; 87281 +PLK1 PLK1 P53350 human MgcRacGAP 29127 Q9H0H5 RACGAP1 human S157 3211992 GsILsDIsFDKtDEs X X +PLK1 PLK1 P53350 human SynGAP iso3 192117 Q9QUH6-3 Syngap1 rat S781 18710211 KMLsVNKsVsMLDLQ DUF3498 X +PLK1 PLK1 P53350 human CENPQ 55166 Q7L2Z9 CENPQ human S139 31868909 EDLtNVssLLNMERA CENP-Q X X +PLK1 PLK1 P53350 human FIRRM 55732 Q9NSG2 FIRRM human S744 50774549 ETKNKVVsFLEkTGF X +PLK1 PLK1 P53350 human CDC25B 994 P30305 CDC25B human S353 452008 VQNkRRRsVtPPEEQ M-inducer_phosp X +PLK1 PLK1 P53350 human Notch 1 4851 P46531 NOTCH1 human S1791 27457604 REPLGEDsVGLkPLK X X +PLK1 PLK1 P53350 human CDC25B 994 P30305 CDC25B human T127 20503410 DPHMAEQtFEQAIQA M-inducer_phosp X +PLK1 PLK1 P53350 human TTK 7272 P33981 TTK human T210 41389703 LSASTVLtAQEsFsG X +PLK1 PLK1 P53350 human TTK 7272 P33981 TTK human S214 14161585 TVLtAQEsFsGsLGH X +PLK1 PLK1 P53350 human CDC25B 994 P30305 CDC25B human T265 20503406 LTPAEGDtEEDDGFV M-inducer_phosp X +PLK1 PLK1 P53350 human KIF2C 11004 Q99661 KIF2C human S633 5779213 ELSsQMssFNEAMTQ X +PLK1 PLK1 P53350 human IRS1 3667 P35568 IRS1 human S24 455604 GYLRKPKsMHKRFFV PH X +PLK1 PLK1 P53350 human TPT1 22070 P63028 Tpt1 mouse S64 3146607 PEGEGTEsTVVTGVD TCTP X +PLK1 PLK1 P53350 human CENPQ 55166 Q7L2Z9 CENPQ human S255 40245504 ssQMKsMstFIEEAY CENP-Q X X +PLK1 PLK1 P53350 human PCNT 5116 O95613 PCNT human S1241 25617501 IsSHMREsFLMsPES X +PLK1 PLK1 P53350 human TTK 7272 P33981 TTK human S362 13194902 TLKNktEssLLAkLE X +PLK1 PLK1 P53350 human Rb 5925 P06400 RB1 human S758 1878197600 SIIVFYNsVFMQRLK X X +PLK1 PLK1 P53350 human CtIP 5932 Q99708 RBBP8 human S723 4766312 EERKMNDsLEDMFDR X X +PLK1 PLK1 P53350 human SUZ12 23512 Q15022 SUZ12 human S541 3208749 KRTkAsMsEFLEsED X +PLK1 PLK1 P53350 human RIOK2 55781 Q9BVS4 RIOK2 human S335 471042 TKEGsEFsFsDGEVA X X +PLK1 PLK1 P53350 human MRE11A 4361 P49959 MRE11 human S688 449207 sKGVDFEssEDDDDD X +PLK1 PLK1 P53350 human KIF2A 3796 O00139 KIF2A human T554 40240801 ANRVKELtVDPTAAG X +PLK1 PLK1 P53350 human optineurin 10133 Q96CV9 OPTN human S177 4762451 ssGssEDsFVEIRMA X X 31304; 57548 +PLK1 PLK1 P53350 human APC1 64682 Q9H1A4 ANAPC1 human S373 455826 VQRFNIssHNQsPkR X +PLK1 PLK1 P53350 human claspin 63967 Q9HAW4 CLSPN human S30 467250 EADSPSDsGQGsYET X +PLK1 PLK1 P53350 human TTK 7272 P33981 TTK human S345 41157083 PLVSDEKsSELIItD X +PLK1 PLK1 P53350 human PIN1 5300 Q13526 PIN1 human S65 456481 sHLLVkHsQSRRPss Rotamase X X +PLK1 PLK1 P53350 human separase 9700 Q14674 ESPL1 human S1399 1211206 KVNFsDDsDLEDPVS X +PLK1 PLK1 P53350 human FBX5 26271 Q9UKT4 FBXO5 human S149 456212 yEDsGYSsFSLQSGL X +PLK1 PLK1 P53350 human SynGAP iso3 192117 Q9QUH6-3 Syngap1 rat S783 18710212 LsVNKsVsMLDLQGD DUF3498 X +PLK1 PLK1 P53350 human RASGRF1 192213 P28818 Rasgrf1 rat S71 18710203 GLYLLEGsICKRMPS PH X +PLK1 PLK1 P53350 human APC7 51434 Q9UJX3 ANAPC7 human S17 455841 MAAAGLHsNVRLLss X +PLK1 PLK1 P53350 human RAP1GAP 5909 P47736 RAP1GAP human S525 450258 AGQKtPDsGHVSQEP X X +PLK1 PLK1 P53350 human APC1 64682 Q9H1A4 ANAPC1 human S547 455831 PLsKLLGsLDEVVLL X +PLK1 PLK1 P53350 human APC1 64682 Q9H1A4 ANAPC1 human S688 452953 FDFEGsLsPVIAPkk Apc1_MidN X +PLK1 PLK1 P53350 human CIP2A 57650 Q8TCG1 CIP2A human S904 482834 NPETVNLsI______ X +PLK1 PLK1 P53350 human RAPGEF2 iso2 9693 Q17RH5 RAPGEF2 human T632 18710213 AIREFAVtATPDQYS RA X X +PLK1 PLK1 P53350 human TNKS 8658 O95271 TNKS human S978 471333 VVSASLIsPAStPSC X X +PLK1 PLK1 P53350 human Survivin 332 O15392 BIRC5 human S20 485776 FLkDHRIstFkNWPF BIR X X +PLK1 PLK1 P53350 human IKKB 3551 O14920 IKBKB human S740 5014909 sFtALDWsWLQTEEE IKKbetaNEMObind X X +PLK1 PLK1 P53350 human GTSE1 51512 Q9NYZ3 GTSE1 human S454 10405611 RsIRRRDsCLNsKTK X X +PLK1 PLK1 P53350 human ZNF198 7750 Q9UBW7 ZMYM2 human S303 18914809 QkQPGVDsLsPVAsL X +PLK1 PLK1 P53350 human axin 1 12005 O35625 Axin1 mouse S157 27266401 LDsNGIVsRQtKPAT RGS X X +PLK1 PLK1 P53350 human CDC27 996 P30260 CDC27 human T205 455848 PEtVLtEtPQDtIEL X +PLK1 PLK1 P53350 human PTP1B 5770 P18031 PTPN1 human S286 27528603 KFIMGDSsVQDQWKE X +PLK1 PLK1 P53350 human USP16 10600 Q9Y5T5 USP16 human S330 29614602 ILKAFGNsTEkLDEE UCH X X +PLK1 PLK1 P53350 human RAPGEF2 iso2 9693 Q17RH5 RAPGEF2 human S1010 1984206 KPVKSETsPVAPRAG X +PLK1 PLK1 P53350 human PLEKHG6 55200 Q3KR16 PLEKHG6 human T574 4145508 HLVVTEDtDEDAPLV X X +PLK1 PLK1 P53350 human CENPQ 55166 Q7L2Z9 CENPQ human S248 40245501 DLDILHNssQMKsMs CENP-Q X X +PLK1 PLK1 P53350 human Tara iso5 11078 Q9H2D6-5 TRIOBP human T457 27171500 QAEEREHtLRRCQQE X X +PLK1 PLK1 P53350 human WDCP 80304 Q9H6R7 WDCP human S695 31855763 sHsPGAVssLKVFTG X X +PLK1 PLK1 P53350 human KIF2B 84643 Q8N4N8 KIF2B human S204 25247528 HLDssKIsVLEPPQE X X +PLK1 PLK1 P53350 human PARK2 5071 O60260 PRKN human S378 454424 AyHEGECsAVFEASG X +PLK1 PLK1 P53350 human CtIP 5932 Q99708 RBBP8 human T731 1868101002 LEDMFDRtTHEEYES X +PLK1 PLK1 P53350 human CTNNB1 1499 P35222 CTNNB1 human S718 5403101 QDDPsyRsFHsGGyG X X +PLK1 PLK1 P53350 human SUN1 iso9 23353 O94901-9 SUN1 human S138 470335 RPPVLDEsWIREQTT MRP X X +PLK1 PLK1 P53350 human Notch 1 4851 P46531 NOTCH1 human S2439 1875193400 SFLSGEPsQADVQPL X X +PLK1 PLK1 P53350 human RIOK2 55781 Q9BVS4 RIOK2 human S380 3211080 PEQIkEdsLsEEsAD X X +PLK1 PLK1 P53350 human NPM1 4869 P06748 NPM1 human S4 452023 ____MEDsMDMDMsP X X 3520 +PLK1 PLK1 P53350 human MDC1 9656 Q14676 MDC1 human T847 30996100 PERQTDVtGEEELTK X X +PLK1 PLK1 P53350 human AurB 9212 Q96GD4 AURKB human T236 4164705 RRktMCGtLDyLPPE Pkinase X X +PLK1 PLK1 P53350 human MST2 6788 Q13188 STK3 human T336 3801535 TSVEsVGtMRATSTM X +PLK1 PLK1 P53350 human FADD 8772 Q13158 FADD human S194 447653 QNRsGAMsPMsWNsD X X 2781 +PLK1 PLK1 P53350 human CDC25B 994 P30305 CDC25B human S513 20503413 RAVNDYPsLYYPEMY Rhodanese X +PLK1 PLK1 P53350 human USP16 10600 Q9Y5T5 USP16 human S486 50592105 SEYEAEMsLQGEVNI UCH X +PLK1 PLK1 P53350 human KIF2B 84643 Q8N4N8 KIF2B human S201 25247534 YRRHLDssKIsVLEP X +PLK1 PLK1 P53350 human GTF3B 2972 Q92994 BRF1 human T270 22996307 RLTEFEDtPTSQLTI TFIIB X +PLK1 PLK1 P53350 human MgcRacGAP 29127 Q9H0H5 RACGAP1 human S149 3211986 RLstIDEsGsILsDI X +PLK1 PLK1 P53350 human CDC25C 995 P30307 CDC25C human S198 448636 sDELMEFsLKDQEAK M-inducer_phosp X X 9529 +PLK1 PLK1 P53350 human GRASP65 64689 Q9BQQ3 GORASP1 human S189 25247500 AAWGGEGsLGCGIGY GRASP55_65 X +PLK1 PLK1 P53350 human BRCA2 675 P51587 BRCA2 human T207 469578 TPPtLsstVLIVRNE X X +PLK1 PLK1 P53350 human PLK1 5347 P53350 PLK1 human T210 448139 YDGERKktLCGtPNy Pkinase X 4354; 5472; 9062 +PLK1 PLK1 P53350 human ACTB 60 P60709 ACTB human S239 3147240 SsSsLEksyELPDGQ Actin X +PLK1 PLK1 P53350 human separase 9700 Q14674 ESPL1 human T1363 1211205 AGPHVPFtVFEEVCP X +PLK1 PLK1 P53350 human ataxin-10 25814 Q9UBB4 ATXN10 human T82 21514208 ASsLQLItECFRCLR X X +PLK1 PLK1 P53350 human MgcRacGAP 29127 Q9H0H5 RACGAP1 human S170 459865 EsLDWDssLVkTFKL X X +PLK1 PLK1 P53350 human CDC25B 994 P30305 CDC25B human S291 20503408 AVPPGMEsLISAPLV M-inducer_phosp X +PLK1 PLK1 P53350 human MYST2 11143 O95251 KAT7 human S57 460899 sQssQDssPVRNLQs X X +PLK1 PLK1 P53350 human GTSE1 51512 Q9NYZ3 GTSE1 human S242 14881300 LLLPRAAsVRGRsIP X +PLK1 PLK1 P53350 human REST 5978 Q13127 REST human S1030 37042902 MsEGsDDsGLHGARP X X +PLK1 PLK1 P53350 human Restin 6249 P30622 CLIP1 human S1364 3189736 DDLNNYDsDDQEKQS X +PLK1 PLK1 P53350 human MTHFR 4524 P42898 MTHFR human T549 178601701 NVKGENItNAPELQP X X +PLK1 PLK1 P53350 human STIL 6491 Q15468 STIL human S1108 17549173 DRSTVGLsLIsPNNM X X +PLK1 PLK1 P53350 human APC4 29945 Q9UJX5 ANAPC4 human S779 455839 kEEVLsEsEAENQQA X +PLK1 PLK1 P53350 human TSC1 7248 Q92574 TSC1 human S468 36132604 GFLGDLAsEEDsIEK Hamartin X +PLK1 PLK1 P53350 human BUB1B 701 O60566 BUB1B human T1008 7652107 LNANDEAtVSVLGEL X X +PLK1 PLK1 P53350 human APC1 64682 Q9H1A4 ANAPC1 human T291 455824 kFsEQGGtPQNVATS X +PLK1 PLK1 P53350 human CCNB1 891 P14635 CCNB1 human S133 448445 sPsPMETsGCAPAEE X X 4133 +PLK1 PLK1 P53350 human TNKS 8658 O95271 TNKS human T1128 21326701 VEEEMQStIREHRDG PARP X X +PLK1 PLK1 P53350 human CENPU 79682 Q71F23 CENPU human T78 471408 FDPPLHstAIyADEE X X +PLK1 PLK1 P53350 human CTNNB1 12387 Q02248 Ctnnb1 mouse S60 1875093002 EEEDVDTsQVLYEWE X X +PLK1 PLK1 P53350 human PINX1 54984 Q96BK5 PINX1 human S117 14823407 sFSLEEKsKISKNRV X X +PLK1 PLK1 P53350 human SynGAP iso3 192117 Q9QUH6-3 Syngap1 rat S407 18710210 GKAKDFLsDMAMSEV RasGAP X +PLK1 PLK1 P53350 human Nlp 22981 Q9Y2I6 NINL human T161 451058 SDEEAEStKEAQNEL X +PLK1 PLK1 P53350 human NEDD1 121441 Q8NHV4 NEDD1 human T382 9379001 PRsINTDtLSkEtDs X +PLK1 PLK1 P53350 human MST2 6788 Q13188 STK3 human S18 20831306 LKkLsEDsLTkQPEE X X +PLK1 PLK1 P53350 human NKX2-1 21869 P50220 Nkx2-1 mouse S23 21478902 ILSPLEEsYKKVGME X X +PLK1 PLK1 P53350 human NUDC 10726 Q9Y266 NUDC human S274 451056 kkINPENskLsDLDs X X +PLK1 PLK1 P53350 human IKKB 3551 O14920 IKBKB human S750 5014910 QTEEEEHsCLEQAS_ X +PLK1 PLK1 P53350 human ROCK2 282041 Q28021 ROCK2 cow T967 1732201 ELTEKDAtIASLEET X +PLK1 PLK1 P53350 human APC7 51434 Q9UJX3 ANAPC7 human S30 455843 ssLLLtMsNNNPELF X +PLK1 PLK1 P53350 human CEP192 55125 Q8TEP8 CEP192 human T44 41159607 GLPVAVStLARDRSS X +PLK1 PLK1 P53350 human Myt1 9088 Q99640 PKMYT1 human T495 449339 LLSLFEDtLDPT___ X X +PLK1 PLK1 P53350 human FOXM1 2305 Q08050 FOXM1 human S730 3194570 VLDTMNDsLSKILLD X X +PLK1 PLK1 P53350 human PINX1 54984 Q96BK5 PINX1 human T141 14823403 DLSSRSKtDLDCIFG X X +PLK1 PLK1 P53350 human WDR62 284403 O43379 WDR62 human S897 291887111 KPESLENsILDSLEP X +PLK1 PLK1 P53350 human TPT1 22070 P63028 Tpt1 mouse S46 476067 TEGAIDDsLIGGNAs TCTP X 5251 +PLK1 PLK1 P53350 human TTK 7272 P33981 TTK human T564 4145511 LEEADNQtLDSYRNE Pkinase X +PLK1 PLK1 P53350 human TOP2A 7153 P11388 TOP2A human S1337 477804 LDsDEDFsDFDEKtD X X +PLK1 PLK1 P53350 human CDC25B 994 P30305 CDC25B human T404 20503407 skAFLLQtVDGkHQD X +PLK1 PLK1 P53350 human ZNF198 7750 Q9UBW7 ZMYM2 human S309 17434113 DsLsPVAsLPkQIFQ X +PLK1 PLK1 P53350 human CTNNB1 1499 P35222 CTNNB1 human S60 1875093002 EEEDVDTsQVLyEWE X X +PLK1 PLK1 P53350 human Myc 4609 P01106 MYC human S77 448586 LLPtPPLsPsRRsGL Myc_N X 13748 +PLK1 PLK1 P53350 human APC1 64682 Q9H1A4 ANAPC1 human S355 455825 AALsrAHsPALGVHs X +PLK1 PLK1 P53350 human TTK 7272 P33981 TTK human S37 2846500 EDLtDELsLNKISAD X +PLK1 PLK1 P53350 human PARP10 84875 Q53GL7 PARP10 human T601 31905435 EVRELLAtLEGLDLD X X +PLK1 PLK1 P53350 human DNAPK 5591 P78527 PRKDC human S3205 452351 tPLPEDNsMNVDQDG FAT X X +PLK1 PLK1 P53350 human KIF23 71819 E9Q5G3 Kif23 mouse S904 459840 TGSRKRRsstLAPAQ X +PLK1 PLK1 P53350 human PPP1R7 5510 Q15435 PPP1R7 human S47 468498 VADLsEQsLkDGEEr X +PLK1 PLK1 P53350 human HSP70 3303 P0DMV8 HSPA1B human S631 483567 AQGPkGGsGsGPtIE X +PLK1 PLK1 P53350 human Chk2 11200 O96017 CHEK2 human T68 447491 SsLEtVstQELYsIP X X 2197; 2661; 28130; 12812; 82263; 64180; 59068 +PLK1 PLK1 P53350 human FBX5 26271 Q9UKT4 FBXO5 human S145 456211 TSRLyEDsGYSsFSL X +PLK1 PLK1 P53350 human KIF2B 84643 Q8N4N8 KIF2B human S200 25247531 EYRRHLDssKIsVLE X +PLK1 PLK1 P53350 human CDC27 996 P30260 CDC27 human S434 455861 LEItkLDssIIsEGk X +PLK1 PLK1 P53350 human GLI1 14632 P47806 Gli1 mouse S481 1412327901 GGSTEDLsSLDEGPC X X +PLK1 PLK1 P53350 human Chk2 11200 O96017 CHEK2 human S164 12473002 IAYIEDHsGNGTFVN FHA X +PLK1 PLK1 P53350 human CENPQ 55166 Q7L2Z9 CENPQ human T135 40245505 PKkMEDLtNVssLLN CENP-Q X X +PLK1 PLK1 P53350 human TTK 7272 P33981 TTK human S363 1737601 LKNktEssLLAkLEE X +PLK1 PLK1 P53350 human supervillin 6840 O95425 SVIL human S238 468886 sFSGRDssFtEVPRs X X +PLK1 PLK1 P53350 human CDC25B 994 P30305 CDC25B human S50 20503402 PVRAAASsPVttLtQ X +PLK1 PLK1 P53350 human CCNB1 891 P14635 CCNB1 human S128 448815 LVDTAsPsPMETsGC X X +PLK1 PLK1 P53350 human BRCA2 675 P51587 BRCA2 human T203 469577 SSLATPPtLsstVLI X +PLK1 PLK1 P53350 human BUB1B 701 O60566 BUB1B human T792 7652106 PRNSAELtVIKVsSQ X X +PLK1 PLK1 P53350 human CDCA5 113130 Q96FF9 CDCA5 human T151 28750703 RsysRLEtLGsASts Sororin X +PLK1 PLK1 P53350 human SAPS2 9701 O75170 PPP6R2 human S289 3176005 GtEGLVDsFsQGLER SAPS X +PLK1 PLK1 P53350 human AMPKA2 5563 P54646 PRKAA2 human T172 448026 sDGEFLRtsCGsPNy Pkinase X 2535; 2531; 5256; 50081; 74281 +PLK1 PLK1 P53350 human Myt1 9088 Q99640 PKMYT1 human S426 449338 CSLLLDSsLSSNWDD X X +PLK1 PLK1 P53350 human Vimentin 7431 P08670 VIM human S339 14582709 ALkGtNEsLERQMRE Filament X X +PLK1 PLK1 P53350 human ZNF198 7750 Q9UBW7 ZMYM2 human S305 483897 QPGVDsLsPVAsLPk X +PLK1 PLK1 P53350 human RAD21 5885 O60216 RAD21 human S454 474526 EPsRLQEsVMEAsRT X +PLK1 PLK1 P53350 human MgcRacGAP 29127 Q9H0H5 RACGAP1 human S214 459867 AVDQGNEsIVAKTTV X +PLK1 PLK1 P53350 human RASGRF1 192213 P28818 Rasgrf1 rat S611 18710207 QMIKSDAsLYCDDVD X +PLK1 PLK1 P53350 human ataxin-10 25814 Q9UBB4 ATXN10 human S77 21514207 QVENLASsLQLItEC X X +PLK1 PLK1 P53350 human CDC25B 994 P30305 CDC25B human T167 20503412 sPVLRNItNsQAPDG M-inducer_phosp X +PLK1 PLK1 P53350 human RAN 5901 P62826 RAN human S135 469112 DRkVKAksIVFHRkk Ras X X +PLK1 PLK1 P53350 human SUGT1 10910 Q9Y2Z0 SUGT1 human S331 18016406 VkRAMNksFMEsGGt SGS X +PLK1 PLK1 P53350 human KIF2C 11004 Q99661 KIF2C human S621 18011291 ALIPGNLsKEEEELS X +PLK1 PLK1 P53350 human CDCA5 113130 Q96FF9 CDCA5 human T115 469416 VPAtPtStPVPNPEA Sororin X +PLK1 PLK1 P53350 human BUB1B 701 O60566 BUB1B human T680 484623 IEDsREAtHSsGFSG X X +PLK1 PLK1 P53350 human MDM2 17246 P23804 Mdm2 mouse S258 454923 SLDsEDYsLSDEGHE X +PLK1 PLK1 P53350 human HSF1 3297 Q00613 HSF1 human S216 4668102 IPLMLNDsGsAHSMP X X +PLK1 PLK1 P53350 human MEK2 5605 P36507 MAP2K2 human S226 448074 LIDsMANsFVGtRSY Pkinase X 2338; 9121; 3958; 9154; 16211; 86128; 16780; 75262 +PLK1 PLK1 P53350 human PTEN 5728 P60484 PTEN human T383 448315 HyRYsDttDsDPENE X 9554; 9549; 7960 +PLK1 PLK1 P53350 human MST2 6788 Q13188 STK3 human S385 4274113 tMKRNAtsPQVQRPs X +PLK1 PLK1 P53350 human SRI 6717 P30626 SRI human T155 25754784 YstNGKItFDDYIAC X X +PLK1 PLK1 P53350 human NuaK1 9891 O60285 NUAK1 human S476 33406502 KKTQQREsGYYsSPE X +PLK1 PLK1 P53350 human STIL 6491 Q15468 STIL human S1116 17400758 LIsPNNMsFAtkKYM X X +PLK1 PLK1 P53350 human CLASP2 23122 O75122 CLASP2 human S1034 7990150 sIsPFNKsALKEAMF X X +PLK1 PLK1 P53350 human CDC27 996 P30260 CDC27 human T446 455863 EGkIStItPQIQAFN X +PLK1 PLK1 P53350 human MRE11A 4361 P49959 MRE11 human S649 455765 EVIEVDEsDVEEDIF X X +PLK1 PLK1 P53350 human Restin 6249 P30622 CLIP1 human S312 4769833 AsLKRsPsAssLsSM X X +PLK1 PLK1 P53350 human MST2 6788 Q13188 STK3 human S316 468210 LEEEEENsDEDELDs X X +PLK1 PLK1 P53350 human BUB1B 701 O60566 BUB1B human S676 767909 LsPIIEDsREAtHSs X +PLK1 PLK1 P53350 human APC1 64682 Q9H1A4 ANAPC1 human T701 455835 kkARPsEtGsDDDWE Apc1_MidN X +PLK1 PLK1 P53350 human APC1 64682 Q9H1A4 ANAPC1 human T530 455829 NtMPRPstPLDGVst X +PLK1 PLK1 P53350 human PTEN 5728 P60484 PTEN human T382 448314 DHyRYsDttDsDPEN X 9554; 9549; 7960 +PLK1 PLK1 P53350 human BORA 79866 Q6PGQ7 BORA human T501 2512943 QMDsGYNtQNCGSNI X +PLK1 PLK1 P53350 human CDC25B 994 P30305 CDC25B human T58 20503403 PVttLtQtMHDLAGL X +PLK1 PLK1 P53350 human TPT1 7178 P13693 TPT1 human S46 476067 tEGNIDDsLIGGNAs TCTP X X 5251 +PLK1 PLK1 P53350 human CDC25B 994 P30305 CDC25B human S209 20503405 PWkPTHPsSTHALAE M-inducer_phosp X +PLK1 PLK1 P53350 human FIRRM 55732 Q9NSG2 FIRRM human S43 31088424 SQARGLSsQNLEIQT X X +PLK1 PLK1 P53350 human Vimentin 22352 P20152 Vim mouse S459 470128 GQVINEtsQHHDDLE X +PLK1 PLK1 P53350 human JIP4 iso2 70834 Q58A65-2 Spag9 mouse T351 3952367 SGYKGSStPTKGIEN X +PLK1 PLK1 P53350 human ROCK2 282041 Q28021 ROCK2 cow S1099 1732202 QAQIAEEsQIRIELQ X +PLK1 PLK1 P53350 human NEDD1 121441 Q8NHV4 NEDD1 human S397 4272994 GkNQDFssFDDtGKs X +PLK1 PLK1 P53350 human SMAD4 4089 Q13485 SMAD4 human T197 1876808208 ASTETyStPALLAPS X +PLK1 PLK1 P53350 human RAD51 5888 Q06609 RAD51 human S14 23305001 LEANADtsVEEESFG X X +PLK1 PLK1 P53350 human MAD2L1BP 9587 Q15013 MAD2L1BP human S102 1245332 kHFyRkPsPQAEEML p31comet X +PLK1 PLK1 P53350 human ROCK2 282041 Q28021 ROCK2 cow S1374 468651 MKIQQNQsIRRPSRQ X +PLK1 PLK1 P53350 human Chk2 11200 O96017 CHEK2 human S210 12473000 DLtVDDQsVYPKALR X +PLK1 PLK1 P53350 human HBXAP 51773 Q96T23 RSF1 human S1359 3072999 ENVGKVGsPLDysLV X X +PLK1 PLK1 P53350 human CDC27 996 P30260 CDC27 human S426 455859 TQPNINDsLEItkLD X +PLK1 PLK1 P53350 human NEK9 91754 Q8TD19 NEK9 human T210 451116 SEYsMAEtLVGtPYY Pkinase X X +PLK1 PLK1 P53350 human IKKB 3551 O14920 IKBKB human S733 5014908 TVREQDQsFtALDWs IKKbetaNEMObind X +PLK1 PLK1 P53350 human Nlp 22981 Q9Y2I6 NINL human S686 451059 LEELHEKsQEVIWGL X +PLK1 PLK1 P53350 human ORC2 4999 Q13416 ORC2 human S188 21507302 SEYSASNsEDDEGVA X X +PLK1 PLK1 P53350 human Vimentin 7431 P08670 VIM human S56 451514 srsLyAssPGGVyAt Filament_head X X 3877; 7391 +PLK1 PLK1 P53350 human RASGRF1 192213 P28818 Rasgrf1 rat S781 18710205 GKTTLDTsKLCVASS X +PLK1 PLK1 P53350 human Survivin 332 O15392 BIRC5 human T21 14150104 LkDHRIstFkNWPFL BIR X +PLK1 PLK1 P53350 human PINX1 54984 Q96BK5 PINX1 human T317 14823404 EDATLEEtLVKKKKK X X +PLK1 PLK1 P53350 human RASGRF1 192213 P28818 Rasgrf1 rat S854 18710204 FPLFNYNsGIMMTCR X +CDK19 CDK19 Q9BWU1 human PAK1 5058 Q13153 PAK1 human S174 7320951 TPAVPPVsEDEDDDD X X +CDK19 CDK19 Q9BWU1 human eIF3-epsilon 8665 O00303 EIF3F human T119 7098400 GAARVIGtLLGTVDK JAB X X +CDK19 CDK19 Q9BWU1 human Notch 1 4851 P46531 NOTCH1 human S2513 35483201 EHPFLtPsPEsPDQW X X +CDK19 CDK19 Q9BWU1 human Notch 1 4851 P46531 NOTCH1 human T2511 483083 VPEHPFLtPsPEsPD X X +CDK19 CDK19 Q9BWU1 human eIF3-epsilon 8665 O00303 EIF3F human S46 448818 PAAAPASsSDPAAAA X X +CDK19 CDK19 Q9BWU1 human Notch 1 4851 P46531 NOTCH1 human S2516 35483202 FLtPsPEsPDQWsss X +Tssk3 TSSK3 Q9D2E1 mouse TSSK3 58864 Q9D2E1 Tssk3 mouse S166 458325 PKSRRELsQtFCGST Pkinase X +Ptk6 Brk Q64434 mouse EPS8 13860 Q08509 Eps8 mouse Y524 457963 NHQVDRNyDAVKTQP X X +Ptk6 Brk Q64434 mouse EPS8 13860 Q08509 Eps8 mouse Y534 63063500 VKTQPKKyAKSKYDF X X +Ptk6 Brk Q64434 mouse CTNNB1 1499 P35222 CTNNB1 human Y64 12170302 VDTsQVLyEWEQGFS X +Ptk6 Brk Q64434 mouse EPS8 13860 Q08509 Eps8 mouse Y497 450735 yAySSSMyHRGPHAD X X +MAK MAK P20794 human MAK 4117 P20794 MAK human T157 4715052 LRSQPPytDyVstRW Pkinase X X +MAK MAK P20794 human MAK 4117 P20794 MAK human Y159 462317 SQPPytDyVstRWYR Pkinase X X +Lck Lck P06240 mouse PKCD 170538 P09215 Prkcd rat Y311 447573 TPETVGIyQGFEKKT X 2055 +Lck Lck P06240 mouse ERK2 26413 P63085 Mapk1 mouse Y185 447594 HtGFLtEyVAtRWYR Pkinase X 9106; 4370; 4374; 9101; 4375; 4376; 4377; 3510; 5726; 88569; 13214; 13148; 70235; 9488; 89967; 8544; 14196; 14227; 14095; 14474; 75165; 98168; 33370; 54240; 15892; 45899; 55088; 9524; 69217; 48735 +Lck Lck P06240 mouse SHIP 16331 Q9ES52 Inpp5d mouse Y918 450030 NEMINPNyIGMGPFG X +Lck Lck P06240 mouse PECAM-1 18613 Q08481 Pecam1 mouse Y702 448760 TRATETVysEIRKVD X +Lck Lck P06240 mouse ZAP70 22637 P43404 Zap70 mouse Y318 447587 TSVyESPySDPEELK X 2701; 2717; 14791; 73382; 82975; 31754 +Lck Lck P06240 mouse Lck 16818 P06240 Lck mouse Y505 447823 FTATEGQyQPQP___ X 2751; 37458 +Lck Lck P06240 mouse CD3Z 12503 P24161 Cd247 mouse Y123 448934 KDKMAEAysEIGTKG ITAM X +Lck Lck P06240 mouse ITK 16428 Q03526 Itk mouse Y517 447997 RFVLDDQyTSSTGTK PK_Tyr_Ser-Thr X +Lck Lck P06240 mouse SHIP 16331 Q9ES52 Inpp5d mouse Y1021 448865 EMFENPLyGsVSSFP X 3941 +Lck Lck P06240 mouse LIME1 72699 Q9EQR5 Lime1 mouse Y261 463811 QGPLENVyESIKEMG LIME1 X +Lck Lck P06240 mouse CTLA-4 12477 P09793 Ctla4 mouse Y201 450897 SPLTTGVyVKMPPTE X X +Lck Lck P06240 mouse CD3Z 12503 P24161 Cd247 mouse Y72 448936 LQDPNQLyNELNLGR ITAM X +Lck Lck P06240 mouse LIME1 72699 Q9EQR5 Lime1 mouse Y242 454608 PLGSDVEyEAINLRG LIME1 X +Lck Lck P06240 mouse CD3Z 12503 P24161 Cd247 mouse Y142 448932 GKGHDGLyQGLsTAT ITAM X +Lck Lck P06240 mouse ZAP70 7535 P43403 ZAP70 human Y493 447505 LGADDsyytARsAGk PK_Tyr_Ser-Thr X X 2704 +Lck Lck P06240 mouse RIAM 54519 Q8R5A3 Apbb1ip mouse Y267 1871479100 FLEKEERyAVFKNPQ X +Lck Lck P06240 mouse ZAP70 22637 P43404 Zap70 mouse Y314 448867 MPMDTSVyESPySDP X +Lck Lck P06240 mouse CD3Z 12503 P24161 Cd247 mouse Y153 455204 sTATKDtyDALHMQT ITAM X +Lck Lck P06240 mouse PECAM-1 18613 Q08481 Pecam1 mouse Y679 448759 PQNMDVEyTEVEVSS X +Lck Lck P06240 mouse ZAP70 7535 P43403 ZAP70 human Y492 447504 ALGADDsyytARsAG PK_Tyr_Ser-Thr X X +Lck Lck P06240 mouse CD3Z 12503 P24161 Cd247 mouse Y83 449322 NLGRREEyDVLEKKR ITAM X +Lck Lck P06240 mouse DLG1 13383 Q811D0 Dlg1 mouse Y222 35530400 GTDADYEyEEITLER MAGUK_N_PEST X +Lck Lck P06240 mouse RIAM 54519 Q8R5A3 Apbb1ip mouse Y427 1871479101 AKYGKTLyDNYQRAV X +Lck Lck P06240 mouse ERK1 5595 P27361 MAPK3 human Y204 447543 HtGFLtEyVAtRWyr Pkinase X 9106; 4370; 4374; 9101; 4375; 4376; 4377; 3510; 5726; 88569; 13214; 13148; 70235; 9488; 89967; 8544; 14196; 14227; 14095; 14474; 75165; 98168; 33370; 54240; 15892; 45899; 55088; 9524; 69217; 48735 +Lck Lck P06240 mouse Lck 16818 P06240 Lck mouse Y394 447822 RLIEDNEytAREGAK PK_Tyr_Ser-Thr X 2101; 6943; 59548; 70926; 78740; 94361; 17320 +Lck Lck P06240 mouse CD3Z 12503 P24161 Cd247 mouse Y111 448933 RNPQEGVyNALQKDK ITAM X +Lck Lck P06240 mouse CTLA-4 12477 P09793 Ctla4 mouse Y218 450898 CEKQFQPyFIPIN__ X X +CDK5 CDK5 Q00535 human Tau iso8 4137 P10636-8 MAPT human T231 449079 KKVAVVRtPPKsPss X 20473; 71429 +CDK5 CDK5 Q00535 human MEF2D 81518 O89038 Mef2d rat S430 449407 SIKSEPVsPSRERSP X +CDK5 CDK5 Q00535 human STMN1 29332 P13668 Stmn1 rat S38 448556 SVPEFPLsPPKKkDL Stathmin X 3426; 4191 +CDK5 CDK5 Q00535 human PIK3C3 5289 Q8NEB9 PIK3C3 human T668 14662701 ENLDLkLtPYKVLAT X +CDK5 CDK5 Q00535 human BACE 23621 P56817 BACE1 human T252 48881800 YTGSLWYtPIRREWY Asp X X +CDK5 CDK5 Q00535 human Tau iso8 4137 P10636-8 MAPT human S199 447927 GDRsGyssPGsPGtP X 29957 +CDK5 CDK5 Q00535 human APP iso4 351 P05067-4 APP human T668 448523 VEVDAAVtPEERHLs APP_amyloid X +CDK5 CDK5 Q00535 human GJA1 14609 P23242 Gja1 mouse S282 448854 tAPLsPMsPPGykLV X +CDK5 CDK5 Q00535 human amphiphysin 273 P49418 AMPH human S285 455793 NHTLAPAsPAPARPR X +CDK5 CDK5 Q00535 human DRD2 1813 P14416 DRD2 human S321 31010702 GLHSTPDsPAkPEKN 7tm_1 X +CDK5 CDK5 Q00535 human 5-HT(6) 3362 P50406 HTR6 human S350 1867750504 ERQAsLAsPSLRTSH X +CDK5 CDK5 Q00535 human liprin alpha 1 233977 B2RXW8 Ppfia1 mouse T700 31873705 PPGsGRStPRRVPHs X +CDK5 CDK5 Q00535 human p70S6K 83840 P67999 Rps6kb1 rat S447 448357 GsPRtPVsPVKFsPG X 9204 +CDK5 CDK5 Q00535 human Lmr1 iso2 11302 Q80YE4-2 Aatk mouse S34 14364500 ADFSEQGsPAAAAQT X X +CDK5 CDK5 Q00535 human XDH 7498 P47989 XDH human T222 40560000 ELLRLKDtPRKQLRF X +CDK5 CDK5 Q00535 human FOXO1A 2308 Q12778 FOXO1 human S249 471071 EGGkSGksPrRrAAs X +CDK5 CDK5 Q00535 human PPP1CA 5499 P62136 PPP1CA human T320 448686 NPGGRPItPPRNsAK X 2581 +CDK5 CDK5 Q00535 human SEPT5 116728 Q9JJM9 Septin5 rat S327 454379 tQDSRMEsPIPILPL X +CDK5 CDK5 Q00535 human STMN3 50861 Q9NZ72 STMN3 human S68 454282 PSDLsPEsPMLssPP Stathmin X +CDK5 CDK5 Q00535 human STMN3 50861 Q9NZ72 STMN3 human S73 454283 PEsPMLssPPKKkDt Stathmin X +CDK5 CDK5 Q00535 human CTNND2 18163 O35927 Ctnnd2 mouse S357 4697626 IGTyATLsPtKRLVH X +CDK5 CDK5 Q00535 human CLIC4 29876 Q9QYB1 Clic4 mouse S108 4782152 PPkYLKLsPkHPESN X X +CDK5 CDK5 Q00535 human MEK2 26396 Q63932 Map2k2 mouse T395 452289 LRLKQPstPtRTAV_ X +CDK5 CDK5 Q00535 human DLC1 10395 Q96QB1 DLC1 human S642 37038504 DSFGSLPsPKELSSF X X +CDK5 CDK5 Q00535 human DBN1 1627 Q16643 DBN1 human S142 452446 NGLARLssPVLHRLR X X +CDK5 CDK5 Q00535 human CASK 12361 O70589 Cask mouse S51 1261103 DVAKFTssPGLsTED Pkinase X +CDK5 CDK5 Q00535 human Kv7.2 iso4 3785 O43526-4 KCNQ2 human S446 481668 ADQSLEDsPSKVPKS KCNQ_channel X +CDK5 CDK5 Q00535 human endophilin B1 54673 Q9JK48 Sh3glb1 mouse T145 26318403 TSALNFLtPLRNFIE BAR X X +CDK5 CDK5 Q00535 human Kv2.1 25736 P15387 Kcnb1 rat S655 473553 RsGFFVEsPRSSMKT Kv2channel X +CDK5 CDK5 Q00535 human Huntingtin 3064 P42858 HTT human S432 457592 AGGGssCsPVLsRKQ X X +CDK5 CDK5 Q00535 human RFA2 6118 P15927 RPA2 human S29 448338 QsPGGFGsPAPsQAE X +CDK5 CDK5 Q00535 human CRMP-2 iso3 1808 NP_001184222 DPYSL2 human S27 23053573 FKNLGsGsPKPRQKF X +CDK5 CDK5 Q00535 human FAK 5747 Q05397 PTK2 human S910 447964 KLQPQEIsPPPtANL X +CDK5 CDK5 Q00535 human Tau 17762 P10637 Mapt mouse T473 447932 kttPsPKtPPGsGEP X 12885; 66224; 62672 +CDK5 CDK5 Q00535 human AR 367 P10275 AR human S310 448413 TEDTAEysPFKGGYT Androgen_recep X X 61248 +CDK5 CDK5 Q00535 human kalirin 545156 A2CG49 Kalrn mouse T1572 3363402 EPIQLPKtPAKLRNN X X +CDK5 CDK5 Q00535 human CDK5R1 116671 P61810 Cdk5r1 rat T138 471393 PAITSAGtPKRVIVQ CDK5_activator X +CDK5 CDK5 Q00535 human CDK5R1 8851 Q15078 CDK5R1 human T138 471393 PAVTSAGtPKRVIVQ CDK5_activator X X +CDK5 CDK5 Q00535 human NDEL1 83431 Q9ERR1 Ndel1 mouse S231 474507 GTENSFPsPKAIPNG NUDE_C X +CDK5 CDK5 Q00535 human p70S6K iso2 6198 P23443-2 RPS6KB1 human S411 448356 SFEPKIRsPRRFIGs X +CDK5 CDK5 Q00535 human p53 7157 P04637 TP53 human S46 447536 AMDDLMLsPDDIEQW TAD2 X X 2521 +CDK5 CDK5 Q00535 human ESYT1 23943 Q3U7R1 Esyt1 mouse S314 15409842 QDVAQLRsPLPRGII X +CDK5 CDK5 Q00535 human PPAR-gamma 19016 P37238 Pparg mouse S273 15175800 TGkTTDKsPFVIYDM X X +CDK5 CDK5 Q00535 human WAVE1 Q5BJU7 Wasf1 rat S397 7979603 APPLVQPsPPVARAA X +CDK5 CDK5 Q00535 human RASGRF1 192213 P28818 Rasgrf1 rat S731 469604 PLAIGtssPVRRRKL RasGEF_N X +CDK5 CDK5 Q00535 human Tau iso8 4137 P10636-8 MAPT human S396 449081 GAEIVyKsPVVsGDt X 9632 +CDK5 CDK5 Q00535 human CLOCK 9575 O15516 CLOCK human T451 30259800 AVsDPSStPTKIPTD X X +CDK5 CDK5 Q00535 human SYN3 27204 Q8JZP2 Syn3 mouse S404 482763 VPGATVPsPLRPWGP X +CDK5 CDK5 Q00535 human CRMP-1 1400 Q14194 CRMP1 human T509 454314 PVyEVPAtPKyAtPA X X +CDK5 CDK5 Q00535 human Tau iso8 4137 P10636-8 MAPT human S404 449082 PVVsGDtsPRHLsNV X X 35834; 20194; 98523; 91600; 49562 +CDK5 CDK5 Q00535 human BRSK2 75770 Q69Z98 Brsk2 mouse S424 2085944 AssGLstsPLssPRV X +CDK5 CDK5 Q00535 human MEK2 26396 Q63932 Map2k2 mouse T397 483596 LKQPstPtRTAV___ X +CDK5 CDK5 Q00535 human KIF2A iso1 16563 P28740-1 Kif2a mouse T474 50269500 LGRNKPHtPFRAsKL Kinesin X +CDK5 CDK5 Q00535 human Tau iso8 4137 P10636-8 MAPT human S262 447930 NVKskIGstENLkHQ Tubulin-binding X +CDK5 CDK5 Q00535 human amphiphysin 273 P49418 AMPH human S272 455791 EEPsPLPsPTAsPNH X +CDK5 CDK5 Q00535 human PDE4B 18578 Q8VBU5 Pde4b mouse S130 468390 SDsDyDLsPKAMSRN X +CDK5 CDK5 Q00535 human nNOS 24598 P29476 Nos1 rat S293 56689901 QSPTKNGsPSRCPRF X +CDK5 CDK5 Q00535 human VRK3 51231 Q8IV63 VRK3 human S108 4762306 RPPtPKssPQKtRKs X X +CDK5 CDK5 Q00535 human HIF1A 3091 Q16665 HIF1A human S687 31876388 TEksHPRsPNVLsVA X X +CDK5 CDK5 Q00535 human TPPP 11076 O94811 TPPP human S18 456612 ANRtPPKsPGDPskD X +CDK5 CDK5 Q00535 human NFL 4747 P07196 NEFL human T21 2872004 ykRRYVEtPrVHISS Filament_head X +CDK5 CDK5 Q00535 human FZR1 51343 Q9UM11 FZR1 human S163 4661904 kSQKLLRsPRKPTRK X +CDK5 CDK5 Q00535 human MEK1 5604 Q02750 MAP2K1 human T292 448287 EtPPRPRtPGRPLss Pkinase X X 26975 +CDK5 CDK5 Q00535 human ADD2 119 P35612 ADD2 human S604 3147414 APAsPVQsPAKEAEt X +CDK5 CDK5 Q00535 human SYN1 281510 P17599 SYN1 cow S553 448377 TRPPAsPsPQRQAGP X +CDK5 CDK5 Q00535 human CTNND2 18163 O35927 Ctnnd2 mouse S300 14910701 rGssPKQsPsRLAKS X +CDK5 CDK5 Q00535 human HSP90A 3320 P07900 HSP90AA1 human S595 31909111 VsNRLVTsPCCIVts HSP90 X X +CDK5 CDK5 Q00535 human Kv-beta2 8514 Q13303 KCNAB2 human S31 3996100 IystrYGsPKRQLQF X +CDK5 CDK5 Q00535 human 5-HT(1A) 3350 P08908 HTR1A human T314 1867735500 LPSEAGPtPCAPASF 7tm_1 X +CDK5 CDK5 Q00535 human CRMP-2 iso3 1808 NP_001184222 DPYSL2 human S627 448082 PASsAKTsPAKQQAP X +CDK5 CDK5 Q00535 human JIP1 19099 Q9WVI9 Mapk8ip1 mouse T201 449954 PLKTGEQtPPHEHIC X +CDK5 CDK5 Q00535 human PARP1 142 P09874 PARP1 human S786 21440501 rGGsDDsskDPIDVN PARP_reg X +CDK5 CDK5 Q00535 human PRMT1 3276 Q99873 PRMT1 human Y309 454762 STsPEsPytHWkQtV X X +CDK5 CDK5 Q00535 human BRSK2 75770 Q69Z98 Brsk2 mouse S513 3572416 MSNLtPEssPELAKK X +CDK5 CDK5 Q00535 human MARCKS 396473 P16527 MARCKS chicken S26 455959 PGEAVAAsPSKANGQ MARCKS X +CDK5 CDK5 Q00535 human ADD1 118 P35611 ADD1 human T724 5246050 KKKKKFRtPsFLKKs X X +CDK5 CDK5 Q00535 human SEPT5 116728 Q9JJM9 Septin5 rat S161 2753800 HCCLYFIsPFGHGLR Septin X +CDK5 CDK5 Q00535 human NDEL1 83431 Q9ERR1 Ndel1 mouse S198 474508 TRKsAPssPtLDCEK NUDE_C X +CDK5 CDK5 Q00535 human PPAR-gamma 19016 P37238 Pparg mouse S112 448062 AIkVEPAsPPYYSEK X +CDK5 CDK5 Q00535 human Rb 5925 P06400 RB1 human S795 447979 sPykFPssPLrIPGG Rb_C X 9301 +CDK5 CDK5 Q00535 human XBP1 22433 O35426 Xbp1 mouse S61 21688102 RQRLTHLsPEEKALR bZIP_1 X X +CDK5 CDK5 Q00535 human NRF2 4780 Q16236 NFE2L2 human T395 40642203 VKQNGPKtPVHSSGD X +CDK5 CDK5 Q00535 human GJA1 14609 P23242 Gja1 mouse S279 448853 SsPtAPLsPMsPPGy X +CDK5 CDK5 Q00535 human Tau iso8 4137 P10636-8 MAPT human T153 449076 DGKtKIAtPRGAAPP X +CDK5 CDK5 Q00535 human p53 7157 P04637 TP53 human S33 447531 LPENNVLsPLPsQAM X 2526 +CDK5 CDK5 Q00535 human WAVE2 242687 Q8BH43 Wasf2 mouse S137 4258800 PPPLNNLsPYRDDGK X +CDK5 CDK5 Q00535 human DBN1 iso3 1627 Q16643-3 DBN1 human S142 452446 NGLARLSsPVLHRLR X X +CDK5 CDK5 Q00535 human Kv2.1 25736 P15387 Kcnb1 rat S607 473555 EATRFSHsPLASLsS Kv2channel X X +CDK5 CDK5 Q00535 human Doublecortin 1641 O43602 DCX human S28 451358 SRMNGLPsPtHSAHC X +CDK5 CDK5 Q00535 human CASK 12361 O70589 Cask mouse S395 1261102 DKINTkSsPQIRNPP L27 X +CDK5 CDK5 Q00535 human DIXDC1 330938 Q80Y83 Dixdc1 mouse S250 15714601 CSSLTSPsPIHSAKs X +CDK5 CDK5 Q00535 human SIRT2 64383 Q8VDQ8 Sirt2 mouse S368 482809 PNPsttIsPGksPPP X X +CDK5 CDK5 Q00535 human MST3 223255 Q99KH8 Stk24 mouse S79 33602703 TVLSQCDsPyVTKYY Pkinase X +CDK5 CDK5 Q00535 human CACNA1G 29717 O54898 Cacna1g rat S2234 15719444 DSTAASPsPKKDTLS X +CDK5 CDK5 Q00535 human STAT3 6774 P40763 STAT3 human S727 448191 NtIDLPMsPrTLDSL X X 9134; 9136; 34911; 94994; 49081; 58978; 87544; 71958; 50804 +CDK5 CDK5 Q00535 human PIP5K1C 23396 O60331 PIP5K1C human S650 457599 DERSWVysPLHYSAQ X X +CDK5 CDK5 Q00535 human PLA2G4A 5321 P47712 PLA2G4A human S505 447597 LNTSYPLsPLSDFAT PLA2_B X X 2831; 53044 +CDK5 CDK5 Q00535 human EFHD2 79180 Q96C19 EFHD2 human S74 478224 QGIGEPQsPsRRVFN X X +CDK5 CDK5 Q00535 human BRSK2 75770 Q69Z98 Brsk2 mouse T502 17554455 RRKLQVPtPEEMSNL X +CDK5 CDK5 Q00535 human MEF2A 4205 Q02078 MEF2A human S408 449949 SIkSEPIsPPRDRMT X X 9737 +CDK5 CDK5 Q00535 human DAB1 266729 Q8CJH2 Dab1 rat S491 479422 TPAPRQSsPSKSSAS X +CDK5 CDK5 Q00535 human CEND1 57754 Q9JKC6 Cend1 mouse S10 10285828 SRGKsAssPKPDtKV CEND1 X X +CDK5 CDK5 Q00535 human amphiphysin 273 P49418 AMPH human S276 455792 PLPsPTAsPNHTLAP X +CDK5 CDK5 Q00535 human p70S6K iso2 6198 P23443-2 RPS6KB1 human S429 471897 PVsPVKFsPGDFWGR X X +CDK5 CDK5 Q00535 human CRMP-1 25415 Q62950 Crmp1 rat T509 454314 PVyEVPAtPkHAaPA X +CDK5 CDK5 Q00535 human CDK5 1020 Q00535 CDK5 human S47 1255792403 DDEGVPssALREICL Pkinase X X +CDK5 CDK5 Q00535 human DLC1 10395 Q96QB1 DLC1 human S946 37038502 SVSPCPSsPKQIHLD X X +CDK5 CDK5 Q00535 human FZR1 51343 Q9UM11 FZR1 human T121 3827860 DRRLQPstPEKkGLF X +CDK5 CDK5 Q00535 human BRSK2 75770 Q69Z98 Brsk2 mouse S468 4734921 PNPtPPssPSVGGVP X +CDK5 CDK5 Q00535 human C9orf72 313155 Q66HC3 RGD1359108 rat S9 27720969 STICPPPsPAVAKTE X X +CDK5 CDK5 Q00535 human BRSK2 75770 Q69Z98 Brsk2 mouse S428 4734873 LstsPLssPRVtPHP X +CDK5 CDK5 Q00535 human eNOS 4846 P29474 NOS3 human S114 448638 RKLQGRPsPGPPAPE X X 9575 +CDK5 CDK5 Q00535 human DNMT1 1786 P26358 DNMT1 human S154 476108 AkPEPsPsPRITRkS X X +CDK5 CDK5 Q00535 human ATM 472 Q13315 ATM human S794 6413900 LSNCTKKsPNKIASG X X +CDK5 CDK5 Q00535 human PPP1R1A 58200 Q9ERT9 Ppp1r1a mouse S67 447758 LKSTLsMsPRQRKKM DARPP-32 X +CDK5 CDK5 Q00535 human Kv-beta2 29738 P62483 Kcnab2 rat S31 3996100 IyStRYGsPKRQLQF X X +CDK5 CDK5 Q00535 human PSEN1 5663 P49768 PSEN1 human T354 451669 HLGPHRstPEsRAAV Presenilin X X +CDK5 CDK5 Q00535 human BRSK2 75770 Q69Z98 Brsk2 mouse T432 17551645 PLssPRVtPHPsPRG X +CDK5 CDK5 Q00535 human BRSK2 75770 Q69Z98 Brsk2 mouse S514 3572419 SNLtPEssPELAKKs X +CDK5 CDK5 Q00535 human talin 1 7094 Q9Y490 TLN1 human S425 1984203 TMLEDsVsPKksTVL X X 5426; 13589 +CDK5 CDK5 Q00535 human CRMP-1 1400 Q14194 CRMP1 human S522 1295503 PAPsAKssPsKHQPP X +CDK5 CDK5 Q00535 human NRF2 4780 Q16236 NFE2L2 human S433 27461383 PEKELPVsPGHrktP X +CDK5 CDK5 Q00535 human FBXO22 26263 Q8NEZ5 FBXO22 human S162 1875332204 VTPMGsGsNRPQEIE X +CDK5 CDK5 Q00535 human DOR-1 24613 P33533 Oprd1 rat T161 455533 VKALDFRtPAKAKLI 7tm_1 X X +CDK5 CDK5 Q00535 human BRSK2 75770 Q69Z98 Brsk2 mouse T460 4734909 PKEsPAGtPNPtPPs X +CDK5 CDK5 Q00535 human CENTG1 iso2 116986 Q99490-2 AGAP2 human S249 478635 ACKSLPSsPSHSAAS X +CDK5 CDK5 Q00535 human Tau iso8 4137 P10636-8 MAPT human S409 449132 DtsPRHLsNVsstGs X +CDK5 CDK5 Q00535 human RASGRF2 19418 P70392 Rasgrf2 mouse S737 2902208 LAVSRTSsPVRARKL RasGEF_N X X +CDK5 CDK5 Q00535 human DRP1 114114 O35303 Dnm1l rat S585 25736596 RETKNVAsAGGGIGD X +CDK5 CDK5 Q00535 human ADD2 119 P35612 ADD2 human S617 3147402 EtKsPLVsPsKsLEE X +CDK5 CDK5 Q00535 human BRSK2 75770 Q69Z98 Brsk2 mouse T448 4734891 PLPtPKGtPVHtPKE X +CDK5 CDK5 Q00535 human GR 2908 P04150 NR3C1 human S226 451796 IDENCLLsPLAGEDD GCR X 97285 +CDK5 CDK5 Q00535 human PIK3C3 5289 Q8NEB9 PIK3C3 human T159 14659500 DGSEPTktPGRtssT PI3K_C2 X X +CDK5 CDK5 Q00535 human STXBP2 6813 Q15833 STXBP2 human T572 487544 IGSSHILtPTRFLDD Sec1 X +CDK5 CDK5 Q00535 human DBN1 iso3 1627 Q16643-3 DBN1 human S342 485840 SSSSSSSsPPRTPFP X X +CDK5 CDK5 Q00535 human Huntingtin 3064 P42858 HTT human S1179 465621 LtNPPsLsPIRRKGK X X +CDK5 CDK5 Q00535 human Kv2.1 25736 P15387 Kcnb1 rat S804 473562 ESsPLPTsPKFLRPN X +CDK5 CDK5 Q00535 human PIP5K1C 23396 O60331 PIP5K1C human S453 15721933 KNsSLKSsPSKKGrG X X +CDK5 CDK5 Q00535 human MCL1 4170 Q07820 MCL1 human T92 4825134 EVPDVTAtPARLLFF X +CDK5 CDK5 Q00535 human PXN 5829 P49023 PXN human S85 451054 HQQPQsssPVyGsSA Paxillin X +CDK5 CDK5 Q00535 human Huntingtin 3064 P42858 HTT human S1199 465620 EQAsVPLsPKKGSEA X X +CDK5 CDK5 Q00535 human GR 2908 P04150 NR3C1 human S203 447967 DLEFSSGsPGkEtNE GCR X X +CDK5 CDK5 Q00535 human CRMP-2 25416 P47942 Dpysl2 rat S522 448082 PASsAKTsPAKQQAP X X +CDK5 CDK5 Q00535 human Tau iso8 4137 P10636-8 MAPT human S202 447928 sGyssPGsPGtPGsR X X 39357; 30505 +CDK5 CDK5 Q00535 human APE1 11792 P28352 Apex1 mouse T232 14645304 NKkNAGFtPQERQGF Exo_endo_phos X +CDK5 CDK5 Q00535 human PKM 5315 P14618 PKM human S37 476070 MCRLDIDsPPItARN X +CDK5 CDK5 Q00535 human BRSK2 75770 Q69Z98 Brsk2 mouse T444 17551641 PRGsPLPtPKGtPVH X +CDK5 CDK5 Q00535 human EPRS 2058 P07814 EPRS1 human S886 452230 LsQssDssPtRNsEP X X +CDK5 CDK5 Q00535 human CDK5R1 8851 Q15078 CDK5R1 human S8 471392 MGTVLSLsPSYRKAT X X +CDK5 CDK5 Q00535 human DLC1 10395 Q96QB1 DLC1 human S557 37038503 LEEFDVFsPKQDLVP X X +CDK5 CDK5 Q00535 human RKIP 5037 P30086 PEBP1 human T42 3189667 DELGkVLtPTQVkNR PBP X X +CDK5 CDK5 Q00535 human girdin 55704 Q3V6T2 CCDC88A human S1675 454193 HHKIKtGsPGsEVVT X X +CDK5 CDK5 Q00535 human BIN1 274 O00499 BIN1 human T348 7532308 VPPPPKHtPSKEVKQ X +CDK5 CDK5 Q00535 human DAB1 iso2 13131 P97318-2 Dab1 mouse S491 479422 tPAPRQSsPSKSSAS X X +CDK5 CDK5 Q00535 human liprin alpha 1 8500 Q13136 PPFIA1 human T701 31873705 PPGsGRstPRRIPHs X X +CDK5 CDK5 Q00535 human KIF2A iso1 16563 P28740-1 Kif2a mouse S503 50269510 TCMIATIsPGMASCE Kinesin X +CDK5 CDK5 Q00535 human Lmr2 22853 Q8IWU2 LMTK2 human S1450 4957483 LQtsKyFsPPPPARS X +CDK5 CDK5 Q00535 human DDHD1 80821 Q8NEL9 DDHD1 human S11 22351356 PGrGsPRsPEHNGRG X +CDK5 CDK5 Q00535 human CDK5R1 116671 P61810 Cdk5r1 rat S8 471392 MGTVLSLsPSYRKAT X +CDK5 CDK5 Q00535 human Kv2.1 25736 P15387 Kcnb1 rat S520 473565 EKARSSssPQHLNVQ Kv2channel X +CDK5 CDK5 Q00535 human CRMP-1 12933 P97427 Crmp1 mouse T509 454314 PVyEVPAtPkHAAPA X +CDK5 CDK5 Q00535 human WAVE2 313024 Q5FWU0 Wasf2 rat S137 4258800 PPPLNNLsPYRDDGK X +CDK5 CDK5 Q00535 human NOXA 5366 Q13794 PMAIP1 human S13 17790900 ARKNAQPsPARAPAE PMAIP1 X X 41967 +CDK5 CDK5 Q00535 human PPAR-gamma 19016 P37238 Pparg mouse T296 38507800 KIKFkHItPLQEQSK X +CDK5 CDK5 Q00535 human TRIM59 286827 Q8IWR1 TRIM59 human S308 50801655 LIPKMKIsPkRMSCS X X +CDK5 CDK5 Q00535 human PPP1R1A 58977 P19103 Ppp1r1a rat S67 447758 LKSTLsMsPRQRKKM DARPP-32 X +CDK5 CDK5 Q00535 human p70S6K 83840 P67999 Rps6kb1 rat S434 448356 SFEPKIRsPRRFIGs X X +CDK5 CDK5 Q00535 human Tau iso8 4137 P10636-8 MAPT human T217 449078 sRtPsLPtPPtREPK X 33134; 51625 +CDK5 CDK5 Q00535 human DDHD1 80821 Q8NEL9 DDHD1 human S727 465585 TIPsPVtsPVLSRRH DDHD X +CDK5 CDK5 Q00535 human FZR1 51343 Q9UM11 FZR1 human S40 3215931 PAssPVssPsKHGDR X +CDK5 CDK5 Q00535 human WAVE1 Q5BJU7 Wasf1 rat S441 7979602 PPGIRPSsPVTVAAL X +CDK5 CDK5 Q00535 human Src 6714 P12931 SRC human S75 450326 NssDtVtsPQRAGPL X +CDK5 CDK5 Q00535 human Tau iso8 4137 P10636-8 MAPT human S214 447929 GsRsRtPsLPtPPtR X 77348 +CDK5 CDK5 Q00535 human PLD2 5338 O14939 PLD2 human S134 456492 ARFAVAYsPARDAGN PX X +CDK5 CDK5 Q00535 human TPPP 11076 O94811 TPPP human S160 487536 GVtKAIssPtVSRLT p25-alpha X +CDK5 CDK5 Q00535 human PPAR-gamma 5468 P37231 PPARG human S273 15175800 TGktTDKsPFVIYDM X +CDK5 CDK5 Q00535 human WAVE1 Q5BJU7 Wasf1 rat S310 4764996 LIENRPQsPAAGRTP X +CDK5 CDK5 Q00535 human DLC1 10395 Q96QB1 DLC1 human S859 37038505 RRENsSDsPKELKRR X X +CDK5 CDK5 Q00535 human BRSK2 75770 Q69Z98 Brsk2 mouse T452 4734897 PKGtPVHtPKEsPAG X +CDK5 CDK5 Q00535 human TRPC6 7225 Q9Y210 TRPC6 human S14 4959823 FGPRrGssPrGAAGA X X +CDK5 CDK5 Q00535 human NUDE1 iso1 54820 Q9NXR1-1 NDE1 human T191 20722719 QKQEKPRtPMPSSVE NUDE_C X +CDK5 CDK5 Q00535 human TPPP 11076 O94811 TPPP human T14 456614 PAKAANRtPPKsPGD X +CDK5 CDK5 Q00535 human DAB1 iso2 13131 P97318-2 Dab1 mouse S400 479417 TNDSARSsPQSDKPR X X +CDK5 CDK5 Q00535 human CENTG1 iso2 116986 Q99490-2 AGAP2 human S279 478561 YSSSLPSsPNVGHRE X X +CDK5 CDK5 Q00535 human RFA2 6118 P15927 RPA2 human S33 448339 GFGsPAPsQAEkkSR X 10148 +CDK5 CDK5 Q00535 human ODFP1 24610 P21769 Odf1 rat S193 2859801 SPCYPCTsPCNPCNP X +CDK5 CDK5 Q00535 human SNTB2 20650 Q61235 Sntb2 mouse S75 471147 NRGLGPPsPPAPPRG X +CDK5 CDK5 Q00535 human p53 7157 P04637 TP53 human S20 447529 PLsQEtFsDLWkLLP P53_TAD X 9287 +CDK5 CDK5 Q00535 human ADD2 119 P35612 ADD2 human S701 1983442 PEGsPsKsPsKKKKK X +CDK5 CDK5 Q00535 human RFA2 6118 P15927 RPA2 human S23 448337 GAGGYtQsPGGFGsP X +CDK5 CDK5 Q00535 human BRSK2 75770 Q69Z98 Brsk2 mouse T510 3572413 PEEMSNLtPEssPEL X +CDK5 CDK5 Q00535 human Tau iso8 4137 P10636-8 MAPT human T181 447932 ktPPAPktPPssGEP X X 12885; 66224; 62672 +CDK5 CDK5 Q00535 human BRSK2 75770 Q69Z98 Brsk2 mouse T464 4734913 PAGtPNPtPPssPSV X +CDK5 CDK5 Q00535 human DARPP-32 19049 Q60829 Ppp1r1b mouse T75 448048 RPNPCAYtPPSLKAV DARPP-32 X 2301 +CDK5 CDK5 Q00535 human DRP1 10059 O00429 DNM1L human S616 454690 PIPIMPAsPQKGHAV X 3455; 4494; 63940 +CDK5 CDK5 Q00535 human SDS3 71954 Q8BR65 Suds3 mouse S228 454398 RTLNKLKsPKRPAsP Sds3 X X +CDK5 CDK5 Q00535 human STMN1 29332 P13668 Stmn1 rat S25 448555 QAFELILsPRSKESV Stathmin X +CDK5 CDK5 Q00535 human CLOCK 9575 O15516 CLOCK human T461 469131 KIPTDTstPPRQHLP X X +CDK5 CDK5 Q00535 human HuR 1994 Q15717 ELAVL1 human S202 3197192 LLsQLyHsPArrFGG X X +CDK5 CDK5 Q00535 human BAG3 9531 O95817 BAG3 human S291 467532 stPLHsPsPIRVHTV X +CDK5 CDK5 Q00535 human MEF2D 4209 Q14814 MEF2D human S444 449407 SIkSEPVsPsRERsP X +CDK5 CDK5 Q00535 human BRSK2 75770 Q69Z98 Brsk2 mouse S490 2085948 IKNSFLGsPRFHRRK X +CDK5 CDK5 Q00535 human PHACTR3 116154 Q96KR7 PHACTR3 human S318 18944907 QGRESKGsPKKRLDV X +CDK5 CDK5 Q00535 human Myc 4609 P01106 MYC human S77 448586 LLPtPPLsPsRRsGL Myc_N X 13748 +CDK5 CDK5 Q00535 human BRSK2 75770 Q69Z98 Brsk2 mouse S456 4734903 PVHtPKEsPAGtPNP X +CDK5 CDK5 Q00535 human CRMP-4 1809 Q14195 DPYSL3 human S522 458800 PAGsArGsPtRPNPP X +CDK5 CDK5 Q00535 human CACNA1B 257648 Q02294 Cacna1b rat S2016 25792205 TQPAPNAsPMKRSIS X +CDK5 CDK5 Q00535 human PARK2 5071 O60260 PRKN human S131 454421 HTDsRkDsPPAGsPA X X +CDK5 CDK5 Q00535 human CDK16 18555 Q04735 Cdk16 mouse S95 453454 tssDEVQsPVRVRMR X +CDK5 CDK5 Q00535 human PLA2G4A 5321 P47712 PLA2G4A human T268 3190702 HNPLLLLtPQkVkRY PLA2_B X X +CDK5 CDK5 Q00535 human CRMP-2 1808 Q16555 DPYSL2 human S522 448082 PAssAktsPAkQQAP X X +CDK5 CDK5 Q00535 human APE1 328 P27695 APEX1 human T233 14645304 NKkNAGFtPQERQGF Exo_endo_phos X +CDK5 CDK5 Q00535 human PKAR2B 24679 P12369 Prkar2b rat T69 10941783 GAAAGGGtPsKGVNF X +CDK5 CDK5 Q00535 human KCNMA1 374065 Q8AYS8 KCNMA1 chicken T871 4715376 QANSQGFtPPGMDRS X +CDK5 CDK5 Q00535 human Tau iso8 4137 P10636-8 MAPT human T212 447934 tPGsRsRtPsLPtPP X +CDK5 CDK5 Q00535 human SIRT2 64383 Q8VDQ8 Sirt2 mouse S372 482810 ttIsPGksPPPAKEA X X +CDK5 CDK5 Q00535 human AR 367 P10275 AR human S83 448714 QQQQQETsPRQQQQQ Androgen_recep X +CDK5 CDK5 Q00535 human Huntingtin 29424 P51111 Htt rat S1150 465621 LTNPPSLsPIRRKGK X +CDK5 CDK5 Q00535 human KIF13B 305967 Q70AM4 Kif13b rat T506 27145806 PEGQVMLtPQKNTRT FHA X +CDK5 CDK5 Q00535 human PARP1 142 P09874 PARP1 human S782 3180399 ySLLrGGsDDsskDP PARP_reg X +CDK5 CDK5 Q00535 human DAB1 266729 Q8CJH2 Dab1 rat S400 479417 TNDSARSsPQSDKPR X +CDK5 CDK5 Q00535 human BRSK2 75770 Q69Z98 Brsk2 mouse S440 4734885 PHPsPRGsPLPtPKG X +CDK5 CDK5 Q00535 human VEGFR2 3791 P35968 KDR human S229 56790201 RIYDVVLsPSHGIEL Ig_3 X +CDK5 CDK5 Q00535 human PPP1R1A 58977 P19103 Ppp1r1a rat S6 478275 __MEPDNsPRKIQFT DARPP-32 X +CDK5 CDK5 Q00535 human SIPA1L1 217692 Q8C0T5 Sipa1l1 mouse S1328 3595500 sLGAstssPRSGPGK X +CDK5 CDK5 Q00535 human CTNNB1 1499 P35222 CTNNB1 human S246 469995 ALVKMLGsPVDSVLF Arm X +CDK5 CDK5 Q00535 human AMFR 267 Q9UKV5 AMFR human S516 3148446 sIRPALNsPVERPss X X +CDK5 CDK5 Q00535 human NDEL1 83431 Q9ERR1 Ndel1 mouse T219 468252 ASLsLPAtPVGKGTE NUDE_C X +CDK5 CDK5 Q00535 human DYN1 1759 Q05193 DNM1 human T780 452368 RsPtssPtPQRRAPA X +CDK5 CDK5 Q00535 human FOXO1A 56458 Q9R1E0 Foxo1 mouse S246 471071 EGGkSGksPRRRAAs X +CDK5 CDK5 Q00535 human p70S6K iso2 6198 P23443-2 RPS6KB1 human S424 448357 GsPRtPVsPVKFsPG X X +CDK5 CDK5 Q00535 human PPP1R1A 58200 Q9ERT9 Ppp1r1a mouse S6 478275 __MEPDNsPRKIQFT DARPP-32 X +CDK5 CDK5 Q00535 human PXN iso2 5829 P49023-2 PXN human S244 465487 VNQGEMSsPQRVtst Paxillin X X +CDK5 CDK5 Q00535 human ACSS2 55902 Q9NR19 ACSS2 human S267 460828 MGDstsQsPPIkRSC AMP-binding X X +CDK5 CDK5 Q00535 human NRF2 4780 Q16236 NFE2L2 human T439 40642202 VsPGHrktPFTkDkH X +CDK5 CDK5 Q00535 human FBXO22 26263 Q8NEZ5 FBXO22 human S160 1875332202 IVVTPMGsGsNRPQE X +CDK5 CDK5 Q00535 human p53 7157 P04637 TP53 human S15 447490 PsVEPPLsQEtFsDL P53_TAD X 4030; 9235; 9284; 9286; 8695; 8514; 82530; 56979 +CDK5 CDK5 Q00535 human Rb 5925 P06400 RB1 human S807 447980 PGGNIyIsPLksPyk Rb_C X 9308; 8974; 4277; 40283; 8957; 8516; 11917; 99274; 41359; 75864; 72443 +CDK5 CDK5 Q00535 human DRP1 114114 O35303 Dnm1l rat S635 454690 PIPIMPAsPQKGHAV X 3455; 4494; 63940 +CDK5 CDK5 Q00535 human PPP1R2 5504 P41236 PPP1R2 human T73 449051 MKIDEPstPyHSMMG IPP-2 X +CDK5 CDK5 Q00535 human PRNP 5621 P04156 PRNP human S43 10273948 SRyPGQGsPGGNRYP X +CDK5 CDK5 Q00535 human HTRA2 27429 O43464 HTRA2 human S400 487467 IHkVILGsPAHRAGL PDZ_6; Peptidase_M50 X X +CDK5 CDK5 Q00535 human SIPA1L1 246212 O35412 Sipa1l1 rat S1367 3595500 SLGASTSsPRSGPGK X +CDK5 CDK5 Q00535 human Huntingtin 29424 P51111 Htt rat S1170 465620 EQTSTPMsPKKGGEA X +CDK5 CDK5 Q00535 human Tau iso8 4137 P10636-8 MAPT human T205 447933 ssPGsPGtPGsRsRt X X 25377; 43964; 53001; 49561; 20060; 33032; 30505; 20739; 98160 +CDK5 CDK5 Q00535 human HDAC5 10014 Q9UQL6 HDAC5 human S279 4788487 KVAERRssPLLRRKD X X +CDK5 CDK5 Q00535 human LRRK2 120892 Q5S007 LRRK2 human S1627 54400802 KHPKGIIsRRDVEKF COR X X +CDK5 CDK5 Q00535 human axin 1 8312 O15169 AXIN1 human T481 451091 HVQRVLRtPGRQsPG Axin_b-cat_bind X +CDK5 CDK5 Q00535 human Kv7.2 iso4 3785 O43526-4 KCNQ2 human S427 15721018 VAAKGKGsPQAQTVR X +CDK5 CDK5 Q00535 human CTNNB1 1499 P35222 CTNNB1 human S191 467710 sRHAIMRsPQMVsAI X +CDK5 CDK5 Q00535 human lamin A/C 4000 P02545 LMNA human S392 452606 ErLRLsPsPtsQRsR X +CDK5 CDK5 Q00535 human Tau iso8 4137 P10636-8 MAPT human S422 449083 GsIDMVDsPQLAtLA X +CDK5 CDK5 Q00535 human TPX2 22974 Q9ULW0 TPX2 human S486 455699 LPItVPksPAFALkN TPX2_importin X X +CDK5 CDK5 Q00535 human Rb 5925 P06400 RB1 human S811 448717 IyIsPLksPykIsEG Rb_C X 9308; 8974; 4277; 40283; 8957; 8516; 11917; 41359; 75864; 63276 +CDK5 CDK5 Q00535 human PARP1 142 P09874 PARP1 human S785 21440500 LrGGsDDsskDPIDV PARP_reg X +CDK5 CDK5 Q00535 human DYN1 140694 P21575 Dnm1 rat S778 450206 GRRsPTSsPTPQRRA X X +CDK5 CDK5 Q00535 human SEPT5 iso2 5413 Q99719-2 SEPTIN5 human S17 475075 RLVEQLLsPRTQAQr X X +CDK5 CDK5 Q00535 human USF2 7392 Q15853 USF2 human S155 36392500 NPFSNGGsPAAEAVS X X +CDK5 CDK5 Q00535 human Tau iso8 4137 P10636-8 MAPT human S235 449080 VVRtPPKsPssAKsR X X 20473 +CDK5 CDK5 Q00535 human Kv-beta2 29738 P62483 Kcnab2 rat S9 486012 YPESTTGsPARLSLR X X +CDK5 CDK5 Q00535 human NFAT5 10725 O94916 NFAT5 human T135 469161 tVQQHPstPkRHtVL X X +CDK5 CDK5 Q00535 human CLASP2 23122 O75122 CLASP2 human S541 24976300 REssRDTsPVRSFQP X +CDK5 CDK5 Q00535 human EPRS 2058 P07814 EPRS1 human S999 9720900 NQGGGLsssGAGEGQ X +CDK5 CDK5 Q00535 human BRSK2 75770 Q69Z98 Brsk2 mouse S436 4734879 PRVtPHPsPRGsPLP X +CDK5 CDK5 Q00535 human gephyrin 64845 Q03555 Gphn rat S283 2020113 LSttPsEsPRAQAts X X +CDK5 CDK5 Q00535 human BAG3 29810 Q9JLV1 Bag3 mouse S297 467532 GtPVHCPsPIRVHTV X +CDK5 CDK5 Q00535 human SAPAP1 65040 P97836 Dlgap1 rat S77 9418959 FPRRHyTsQQELKDE X +CDK5 CDK5 Q00535 human USF2 7392 Q15853 USF2 human S222 9285181 APRTHPysPkIDGtR X X +CDK5 CDK5 Q00535 human TRPV1 193034 Q704Y3 Trpv1 mouse T407 473576 IAYSSSEtPNRHDML X +CDK5 CDK5 Q00535 human GR 2908 P04150 NR3C1 human S211 447968 PGkEtNEsPWRSDLL GCR X X 4161 +CDK5 CDK5 Q00535 human Vimentin 7431 P08670 VIM human S56 451514 srsLyAssPGGVyAt Filament_head X 3877; 7391 +CDK5 CDK5 Q00535 human BRSK2 75770 Q69Z98 Brsk2 mouse S467 4734917 tPNPtPPssPSVGGV X +CDK5 CDK5 Q00535 human VACAMKL 235604 Q3UHL1 Camkv mouse T345 60179300 QSASDAAtPGAAGGA X +CDK5 CDK5 Q00535 human TH 21823 P24529 Th mouse S31 448544 KQAEAVtsPRFIGRR TOH_N X 3370; 13041 +Dapk1 DAPK1 Q80YE7 mouse MRLC2 67938 Q3THE2 Myl12b mouse S20 448595 KRPQRAtsNVFAMFD X X +Dapk1 DAPK1 Q80YE7 mouse MRLC2 67938 Q3THE2 Myl12b mouse T19 448596 KKRPQRAtsNVFAMF X X +Dapk1 DAPK1 Q80YE7 mouse DAPK1 69635 Q80YE7 Dapk1 mouse S308 448142 ARKKWKQsVRLISLC X +Dapk1 DAPK1 Q80YE7 mouse MRLC2 103910 O14950 MYL12B human S20 448595 KRPQRAtsNVFAMFD X +Dapk1 DAPK1 Q80YE7 mouse NMDAR2B 14812 Q01097 Grin2b mouse S1303 450171 NKLRRQHsyDtFVDL NMDAR2_C X X 20274; 71335 +Ptk2b Pyk2 Q9QVP9 mouse IKKB 16150 O88351 Ikbkb mouse Y188 449632 sFVGTLQyLAPELLE Pkinase X X +Ptk2b Pyk2 Q9QVP9 mouse TBK1 56480 Q9WUN2 Tbk1 mouse Y179 23151249 sLYGTEEyLHPDMYE Pkinase X X +Ptk2b Pyk2 Q9QVP9 mouse DDEF1 13196 Q9QWY8 Asap1 mouse Y308 450437 PKEVGGLyVASRANS X X +Ptk2b Pyk2 Q9QVP9 mouse PXN 19303 Q8VI36 Pxn mouse Y31 448785 FLsEEPPysyPTGNH X +Ptk2b Pyk2 Q9QVP9 mouse IKKB 16150 O88351 Ikbkb mouse Y199 449633 ELLEQQKyTVTVDYW Pkinase X X +Ptk2b Pyk2 Q9QVP9 mouse Pyk2 19229 Q9QVP9 Ptk2b mouse Y402 447955 CSIESDIyAEIPDET X X 3291 +Camk1d CAMK1D iso2 Q8BW96-2 mouse CAMK1D iso2 227541 Q8BW96-2 Camk1d mouse S349 7101531 SFLLRRGsQESELRG X X +NME2 NME2 P22392 human NME2 4831 P22392 NME2 human H118 474519 QVGrNIIhGsDsVkS NDK X +NME2 NME2 P22392 human G-beta 1 2782 P62873 GNB1 human H266 9643001 QELMTYShDNIICGI WD40 X +NME2 NME2 P22392 human KCNN4 3783 O15554 KCNN4 human H358 474525 FRQVRLKhRKLREQV CaMBD X X +PNCK CAMK1B Q6P2M8 human HSP90A 3320 P07900 HSP90AA1 human S391 18495100 FIrGVVDsEDLPLNI HSP90 X X +PNCK CAMK1B Q6P2M8 human EIF4G3 8672 O43432 EIF4G3 human S1156 2915400 NTFMRGGssKDLLDN X X +PNCK CAMK1B Q6P2M8 human HSP90B 3326 P08238 HSP90AB1 human T89 18495101 RtLtLVDtGIGMtkA HATPase_c X X +PNCK CAMK1B Q6P2M8 human HSP90A 3320 P07900 HSP90AA1 human T624 8149779 QALRDNstMGyMAAk HSP90 X X +Mapk1 ERK2 P63086 rat p90RSK 6195 Q15418 RPS6KA1 human T573 447993 AENGLLMtPCytANF Pkinase X 9346 +Mapk1 ERK2 P63086 rat GJA1 24392 P08050 Gja1 rat S282 448854 TAPLsPMsPPGYkLV X +Mapk1 ERK2 P63086 rat vinexin 282843 Q8CJ75 Sorbs3 rat S593 452554 DSPQLPTsPHLTTTA X +Mapk1 ERK2 P63086 rat CASP9 842 P55211 CASP9 human T125 449563 PEVLRPEtPRPVDIG X +Mapk1 ERK2 P63086 rat ERK2 26413 P63085 Mapk1 mouse Y185 447594 HtGFLtEyVAtRWYR Pkinase X 9106; 4370; 4374; 9101; 4375; 4376; 4377; 3510; 5726; 88569; 13214; 13148; 70235; 9488; 89967; 8544; 14196; 14227; 14095; 14474; 75165; 98168; 33370; 54240; 15892; 45899; 55088; 9524; 69217; 48735 +Mapk1 ERK2 P63086 rat GR 24413 P06536 Nr3c1 rat S246 451796 LIDENLLsPLAGEDD GCR X 97285 +Mapk1 ERK2 P63086 rat TRPV2 29465 Q9WUD2 Trpv2 rat S6 29631548 __MTSASsPPAFRLE X +Mapk1 ERK2 P63086 rat TRPV2 29465 Q9WUD2 Trpv2 rat S47 12738661 QREDRNSsPQIKVNL X +Mapk1 ERK2 P63086 rat AML1 861 Q01196 RUNX1 human S266 454400 QYLGsIAsPsVHPAt X X +Mapk1 ERK2 P63086 rat Fos 314322 P12841 Fos rat T331 448484 CtPVVTCtPSCTTYT X +Mapk1 ERK2 P63086 rat SYN1 24949 P09951 Syn1 rat S62 451572 stAAPVAsPAAPsPG X +Mapk1 ERK2 P63086 rat ERK2 116590 P63086 Mapk1 rat T183 447593 HDHtGFLtEyVAtRW Pkinase X 9106; 4370; 4374; 9101; 4375; 4376; 4377; 3510; 5726; 88569; 13214; 13148; 70235; 9488; 89967; 8544; 14196; 14227; 14095; 14474; 75165; 98168; 33370; 54240; 15892; 45899; 55088; 9524; 69217; 48735 +Mapk1 ERK2 P63086 rat DUSP6 116663 Q64346 Dusp6 rat S197 455266 SATDSDGsPLSNSQP X +Mapk1 ERK2 P63086 rat SYN1 24949 P09951 Syn1 rat S549 451574 PAARPPAsPsPQRQA X +Mapk1 ERK2 P63086 rat LIFR 3977 P42702 LIFR human S1044 450385 WNLVsPDsPRsIDSN X +Mapk1 ERK2 P63086 rat PTP-SL iso2 19279 Q62132-2 Ptprr mouse T253 450119 EPFVAVStPREKVAM X +Mapk1 ERK2 P63086 rat ARG3.1 54323 Q63053 Arc rat S206 149319101 PGEDGQPsPGVDTQI X +Mapk1 ERK2 P63086 rat Fos 314322 P12841 Fos rat S374 448482 PSSDSLSsPTLLAL_ X +Mapk1 ERK2 P63086 rat GJA1 24392 P08050 Gja1 rat S279 448853 SSPTAPLsPMsPPGY X +Mapk1 ERK2 P63086 rat SP1 6667 P08047 SP1 human T739 448227 sEGSGtAtPSALITT X +Mapk1 ERK2 P63086 rat ERK2 116590 P63086 Mapk1 rat T188 3949250 FLtEyVAtRWYRAPE Pkinase X +Mapk1 ERK2 P63086 rat TH 25085 P04177 Th rat S8 448543 MPTPSAPsPQPKGFR TOH_N X +Mapk1 ERK2 P63086 rat ENaC-gamma 24768 P37091 Scnn1g rat T623 451220 PGSTVPGtPPPRYNT X +Mapk1 ERK2 P63086 rat SYN1 24949 P09951 Syn1 rat S67 451573 VAsPAAPsPGSSGGG X +Mapk1 ERK2 P63086 rat UBF 25574 P25977 Ubtf rat T117 448504 DFPKKPLtPYFRFFM HMG_box X X +Mapk1 ERK2 P63086 rat ARG3.1 54323 Q63053 Arc rat T368 149319103 QAAEPSVtPLPTEDE X +Mapk1 ERK2 P63086 rat Bcl-3 602 P20749 BCL3 human S122 143278600 CPMEHPLsADIAMAT X +Mapk1 ERK2 P63086 rat TRPV2 29465 Q9WUD2 Trpv2 rat S37 8110156 QEPPPMEsPFQREDR X +Mapk1 ERK2 P63086 rat AML1 861 Q01196 RUNX1 human S249 454399 DTRQIQPsPPWsyDQ X X 4327 +Mapk1 ERK2 P63086 rat SMAD3 4088 P84022 SMAD3 human S208 451179 DAGsPNLsPNPMsPA X +Mapk1 ERK2 P63086 rat PDE4D iso6 24627 P14270-6 Pde4d rat S585 451090 YQSTIPQsPSPAPDD X +Mapk1 ERK2 P63086 rat ENaC-beta 24767 P37090 Scnn1b rat T613 451219 QTLPIPGtPPPNYDS X +Mapk1 ERK2 P63086 rat ERK2 116590 P63086 Mapk1 rat Y185 447594 HtGFLtEyVAtRWYR Pkinase X 9106; 4370; 4374; 9101; 4375; 4376; 4377; 3510; 5726; 88569; 13214; 13148; 70235; 9488; 89967; 8544; 14196; 14227; 14095; 14474; 75165; 98168; 33370; 54240; 15892; 45899; 55088; 9524; 69217; 48735 +Mapk1 ERK2 P63086 rat JunD 24518 P52909 Jund rat S100 456168 LGLLKLAsPELERLI Jun X 9164 +Mapk1 ERK2 P63086 rat GR 24413 P06536 Nr3c1 rat T171 451795 TSATGCAtPTEKEFP GCR X +Mapk1 ERK2 P63086 rat PAK1 29431 P35465 Pak1 rat T211 448176 VIEPLPVtPTRDVAT X X +Mapk1 ERK2 P63086 rat Myc 4609 P01106 MYC human S77 448586 LLPtPPLsPsRRsGL Myc_N X 13748 +Mapk1 ERK2 P63086 rat GATA4 54254 P46152 Gata4 rat S105 449604 AYTPPPVsPRFSFPG GATA-N X +Mapk1 ERK2 P63086 rat SP1 6667 P08047 SP1 human T453 448226 SGPIIIRtPTVGPNG X +Mapk1 ERK2 P63086 rat EFNB3 360546 G3V7D4-1 Efnb3 rat S332 27722391 VQDGPPQsPPNIYYK X +Mapk1 ERK2 P63086 rat TRPV2 29465 Q9WUD2 Trpv2 rat S760 7103644 LPLQVLQsP______ X +Mapk1 ERK2 P63086 rat UBF 25574 P25977 Ubtf rat T201 448505 DIPEKPKtPQQLWYT HMG_box X X +Mapk1 ERK2 P63086 rat TH 25085 P04177 Th rat S31 448544 KQAEAVtsPRFIGRR TOH_N X X 3370; 13041 +Mapk1 ERK2 P63086 rat GRASP65 56082 O35254 Gorasp1 rat S277 455582 EQLPGPGsPGHGTAD X +Mapk1 ERK2 P63086 rat ARG3.1 54323 Q63053 Arc rat T380 149319102 EDETEALtPALTSES X +PRKD2 PRKD2 Q9BZL6 human IFNAR1 3454 P17181 IFNAR1 human S535 454418 SSQTsQDsGNysNED X X +PRKD2 PRKD2 Q9BZL6 human PAK4 10298 O96013 PAK4 human S99 2192540 MsVTRsNsLRRDsPP X X +PRKD2 PRKD2 Q9BZL6 human PIK4CB iso2 5298 Q9UBF8-2 PI4KB human S294 457621 SNLKRtAsNPKVENE X X +PRKD2 PRKD2 Q9BZL6 human Cortactin 2017 Q14247 CTTN human S298 5014901 EKLAkHEsQQDyskG HS1_rep X +PRKD2 PRKD2 Q9BZL6 human SET iso2 6418 Q01105-2 SET human S171 27425001 KDLTKRSsQTQNKAs NAP X X +PRKD2 PRKD2 Q9BZL6 human arfaptin 1 iso2 27236 P53367-2 ARFIP1 human S100 3191827 LELVRKWsLNTYKCT Arfaptin X X +PRKD2 PRKD2 Q9BZL6 human ITGB4 iso2 3691 P16144-2 ITGB4 human T1736 1243302 EFVSRTLttSGTLST X +PRKD2 PRKD2 Q9BZL6 human MFF 56947 Q9GZY8 MFF human S172 484865 GQLVRNDsLWHRsDs Miff X +PRKD2 PRKD2 Q9BZL6 human CIB1 10519 Q99828 CIB1 human S78 479918 ERICRVFsTSPAKDS X X +PRKD2 PRKD2 Q9BZL6 human VASP 7408 P50552 VASP human S239 448380 GAKLRKVsKQEEASG X 3114; 37565 +PRKD2 PRKD2 Q9BZL6 human HDAC7 51564 Q8WUI4 HDAC7 human S181 470131 NPLLRKEsAPPsLRR X +PRKD2 PRKD2 Q9BZL6 human SSH1 54434 Q8WYL5 SSH1 human S978 455275 sPLKRSHsLAKLGSL X +PRKD2 PRKD2 Q9BZL6 human HDAC5 10014 Q9UQL6 HDAC5 human S498 447996 RPLSRtQsSPLPQsP X 3424 +PRKD2 PRKD2 Q9BZL6 human PKD2 5311 Q13563 PKD2 human S801 15702202 SSLPRPMsSRSFPRs X +PRKD2 PRKD2 Q9BZL6 human MARK2 2011 Q7KZI7 MARK2 human S400 5635600 HkVQRsVsANPKQRR X +PRKD2 PRKD2 Q9BZL6 human PRKD2 25865 Q9BZL6 PRKD2 human S876 448800 QGLAERIsVL_____ X +PRKD2 PRKD2 Q9BZL6 human Rin1 9610 Q13671 RIN1 human S292 4949757 QLLRREssVGyRVPA X +PRKD2 PRKD2 Q9BZL6 human SSH1 54434 Q8WYL5 SSH1 human S937 455274 SNLtRssssDsIHsV X +PRKD2 PRKD2 Q9BZL6 human VASP 7408 P50552 VASP human S157 448379 EHIERRVsNAGGPPA X 3111; 84519 +PRKD2 PRKD2 Q9BZL6 human VASP 7408 P50552 VASP human S322 469024 TtLPRMkssssVttS X +CAMK2B CAMK2B Q13554 human GSK3B 84027 P18266 Gsk3b rat S9 449111 SGRPRTTsFAESCKP X 9336; 9331; 9327; 9323; 9322; 9325; 5558; 8566; 79774; 8466; 25462; 14026; 14332; 14310; 14630 +CAMK2B CAMK2B Q13554 human SAPAP1 iso2 9229 O14490-2 DLGAP1 human S393 4775408 RRFTRSNsVTTAVQA GKAP X +CAMK2B CAMK2B Q13554 human SAPAP1 iso2 9229 O14490-2 DLGAP1 human S349 2049913 FKKNRCLsIGIQVDD GKAP X +CAMK2B CAMK2B Q13554 human CAMK2B 12323 P28652 Camk2b mouse T311 15719513 ILttMLAtRNFsVGR X X +CAMK2B CAMK2B Q13554 human CAMK2B 12323 P28652 Camk2b mouse T307 2020797 LkGAILttMLAtRNF X X +CAMK2B CAMK2B Q13554 human AMPKA1 5562 Q13131 PRKAA1 human T183 448786 sDGEFLRtsCGsPNy Pkinase X 2535; 2531; 4188; 5256; 50081; 74281 +CAMK2B CAMK2B Q13554 human ITGB1 3688 P05556 ITGB1 human T789 447709 IyksAVttVVNPkyE Integrin_b_cyt X +CAMK2B CAMK2B Q13554 human STMN1 3925 P16949 STMN1 human S16 448554 kELEKrAsGQAFELI Stathmin X 3353 +CAMK2B CAMK2B Q13554 human FAM134B 54463 Q9H6L5 RETREG1 human S151 2509195 AQLWRSLsESWEVIN Reticulon X X +CAMK2B CAMK2B Q13554 human GABBR1 81657 Q9Z0U4 Gabbr1 rat S898 15167000 ITRGEWQsETQDtMK X +CAMK2B CAMK2B Q13554 human CAMK2B 12323 P28652 Camk2b mouse S26 455245 DIGkGAFsVVRRCVk Pkinase X X +CAMK2B CAMK2B Q13554 human CAMK2B 12323 P28652 Camk2b mouse S182 18007574 AGtPGYLsPEVLRKE Pkinase X +CAMK2B CAMK2B Q13554 human CAMK2B 12323 P28652 Camk2b mouse T306 451706 kLkGAILttMLAtRN X X +CAMK2B CAMK2B Q13554 human ITGB1 3688 P05556 ITGB1 human T788 448600 PIyksAVttVVNPky Integrin_b_cyt X +CAMK2B CAMK2B Q13554 human occludin 100506658 Q16625 OCLN human S471 6094301 LDDyREEsEEyMAAA Occludin_ELL X +CAMK2B CAMK2B Q13554 human CAMK2B 12323 P28652 Camk2b mouse T287 450048 sMMHRQEtVECLKKF X X 12716 +CAMK2B CAMK2B Q13554 human CAMK2G 818 Q13555 CAMK2G human T287 467596 sMMHRQEtVECLRKF X 12716 +CAMK2B CAMK2B Q13554 human CAMK2B 816 Q13554 CAMK2B human T287 450048 sMMHRQEtVECLKKF X 12716 +CAMK2B CAMK2B Q13554 human GSK3A 50686 P18265 Gsk3a rat S21 448584 SGRARtssFAEPGGG X 9337; 9316; 9331; 9327; 8452; 8566 +PAK5 PAK5 Q9P286 human DDX5 1655 P17844 DDX5 human T69 1875793000 HPDLARRtAQEVETY X X +PAK5 PAK5 Q9P286 human PAK5 57144 Q9P286 PAK5 human S573 11327000 HRDIKSDsILLTSDG Pkinase X +PAK5 PAK5 Q9P286 human syntaphilin iso2 9751 O15079-2 SNPH human S59 50800758 SRRTsAGsRRRtsPP X +PAK5 PAK5 Q9P286 human E2A 6929 P15923 TCF3 human S39 15500103 NGkGRPAsLAGAQFG X X +PAK5 PAK5 Q9P286 human syntaphilin iso2 9751 O15079-2 SNPH human S64 481340 AGsRRRtsPPVSVRD Syntaphilin X +PAK5 PAK5 Q9P286 human DNPEP iso2 23549 Q9ULA0-2 DNPEP human S109 34733463 VKRRSRRsQVGFQQV Peptidase_M18 X X +PAK5 PAK5 Q9P286 human GATA1 2623 P15976 GATA1 human S161 40407600 SSLPVPNsAYGGPDF X X +PAK5 PAK5 Q9P286 human SRSF11 9295 Q05519 SRSF11 human S287 470248 KSRSRRRsKsPRRRR X X +PAK5 PAK5 Q9P286 human syntaphilin iso2 9751 O15079-2 SNPH human S56 23150247 LPGSRRTsAGsRRRt X +PAK5 PAK5 Q9P286 human GATA1 2623 P15976 GATA1 human S187 451237 LNSAAYSsPKLRGTL X +PAK5 PAK5 Q9P286 human PDCD8 9131 O95831 AIFM1 human T281 1872824900 GAEVksRtTLFRKIG Pyr_redox_2 X +PAK5 PAK5 Q9P286 human syntaphilin iso2 9751 O15079-2 SNPH human T63 23150253 sAGsRRRtsPPVSVR Syntaphilin X +Wnk1 WNK1 Q9JIH7 rat WNK4 287715 Q7TPK6 Wnk4 rat S332 456207 KRASFAKsVIGTPEF Pkinase X +Wnk1 WNK1 Q9JIH7 rat WNK1 116477 Q9JIH7 Wnk1 rat S378 456474 LATLKRAsFAKsVIG Pkinase X +Wnk1 WNK1 Q9JIH7 rat WNK1 116477 Q9JIH7 Wnk1 rat S382 454105 KRAsFAKsVIGTPEF Pkinase X +Wnk1 WNK1 Q9JIH7 rat SYT2 20980 P46097 Syt2 mouse T202 454031 ETKVHRKtLNPAFNE C2 X X +Wnk1 WNK1 Q9JIH7 rat SYT2 20980 P46097 Syt2 mouse T386 454032 VGSNATGtELRHWSD C2 X +DCLK1 DCAMKL1 O15075 human IKKB 16150 O88351 Ikbkb mouse S181 447489 DQGsLCTsFVGTLQy Pkinase X X 2697; 2694; 14938; 92255; 36516; 36214 +DCLK1 DCAMKL1 O15075 human CCAR1 55749 Q8IX12 CCAR1 human S343 470613 RKRsRERsPRRERER X +DCLK1 DCAMKL1 O15075 human IKKB 16150 O88351 Ikbkb mouse S177 447492 AKELDQGsLCTsFVG Pkinase X X 2078; 2697; 2694; 14938; 92255; 36516; 36214 +ACVR1B ALK4 P36896 human TTRAP 51567 O95551 TDP2 human T88 12563300 PkTyVDLtNEEtTDs X +ACVR1B ALK4 P36896 human TTRAP 51567 O95551 TDP2 human T92 12563301 VDLtNEEtTDsTTSK X +CASK CASK O14936 human CASK 8573 O14936 CASK human S151 2506803 PHCVLLAsKENsAPV Pkinase X +CASK CASK O14936 human NRXN1 iso1 9378 P58400-1 NRXN1 human S425 2506806 VKEKQPssAKsSNKN Syndecan X +CASK CASK O14936 human NRXN1 iso1 9378 P58400-1 NRXN1 human S424 2506807 VVKEKQPssAKsSNK Syndecan X +CASK CASK O14936 human CASK 8573 O14936 CASK human S155 2506804 LLAsKENsAPVKLGG Pkinase X +CASK CASK O14936 human NRXN1 iso1 9378 P58400-1 NRXN1 human S428 2506805 KQPssAKsSNKNKKN Syndecan X +FGFR3 FGFR3 P22607 human FGFR3 2261 P22607 FGFR3 human Y724 448116 ANCTHDLyMIMRECW PK_Tyr_Ser-Thr X +FGFR3 FGFR3 P22607 human CTNNB1 1499 P35222 CTNNB1 human Y142 449044 AVVNLINyQDDAELA X X +FGFR3 FGFR3 P22607 human PTEN 5728 P60484 PTEN human Y240 448316 RREDKFMyFEFPQPL PTEN_C2 X +FGFR3 FGFR3 P22607 human FGFR3 2261 P22607 FGFR3 human Y648 463337 DVHNLDyyKKTTNGR PK_Tyr_Ser-Thr X +FGFR3 FGFR3 P22607 human FGFR3 2261 P22607 FGFR3 human Y647 463336 RDVHNLDyyKKTTNG PK_Tyr_Ser-Thr X +FGFR3 FGFR3 P22607 human GLO1 2739 Q04760 GLO1 human Y136 463450 GIAVPDVysACkRFE Glyoxalase X +FGFR3 FGFR3 P22607 human TET2 54790 Q6N021 TET2 human Y1902 1870773107 TRISLVFyQHKSMNE Tet_JBP X +FGFR3 FGFR3 P22607 human RSK2 6197 P51812 RPS6KA3 human Y529 464205 TITKTVEyLHAQGVV Pkinase X X +FGFR3 FGFR3 P22607 human ICK 22858 Q9UPZ9 CILK1 human Y15 35479600 RQLGDGtyGsVLLGR Pkinase X +FGFR3 FGFR3 P22607 human RSK2 6197 P51812 RPS6KA3 human Y488 464203 DVyDDGKyVYVVTEL Pkinase X +FGFR3 FGFR3 P22607 human STAT1 6772 P42224 STAT1 human Y701 447754 DGPkGtGyIktELIs X 9174; 9167; 5375; 25685; 8062; 8183; 8009; 55603; 7649; 25809; 57216; 45118; 39205; 88845; 88211; 76285; 90145 +TLK2 TLK2 Q86UE8 human ASF1B 55723 Q9NVP2 ASF1B human S198 7997068 PGLLPENsMDCI___ X +TLK2 TLK2 Q86UE8 human ASF1A 25842 Q9Y294 ASF1A human S192 12671900 GWSTSENsLNVMLES X +MAP2K6 MKK6 P52564 human P38G 6300 P53778 MAPK12 human Y185 448032 ADsEMtGyVVTRWYR Pkinase X 9211; 9215; 4551; 9216; 4552; 4631; 4511; 4092; 9219; 24678; 8632; 6908; 41768; 51255; 14594; 14598; 62979 +MAP2K6 MKK6 P52564 human P38D 26415 Q9Z1B7 Mapk13 mouse Y182 454935 TDTEMtGyVVTRWYR Pkinase X 9211; 9215; 4551; 9216; 4552; 4631; 4511; 4092; 9219; 24678; 8632; 6908; 41768; 51255; 14594; 14598; 62979 +MAP2K6 MKK6 P52564 human HSF4 3299 Q9ULV5 HSF4 human T471 30318200 LGLPGALtIYSTPES X +MAP2K6 MKK6 P52564 human P38A 26416 P47811 Mapk14 mouse T180 447970 RHtDDEMtGyVAtRW Pkinase X X 9211; 9215; 4551; 9216; 4552; 4631; 4511; 4092; 9219; 24678; 8632; 6908; 41768; 51255; 14594; 14598; 62979 +MAP2K6 MKK6 P52564 human P38G 6300 P53778 MAPK12 human T183 448031 RQADsEMtGyVVTRW Pkinase X 9211; 9215; 4551; 9216; 4552; 4631; 4511; 4092; 9219; 24678; 8632; 6908; 41768; 51255; 14594; 14598; 62979 +MAP2K6 MKK6 P52564 human PAK6 56924 Q9NQU5 PAK6 human Y566 454426 KsLVGtPyWMAPEVI Pkinase X +MAP2K6 MKK6 P52564 human P38A 81649 P70618 Mapk14 rat T180 447970 RHTDDEMtGyVATRW Pkinase X 9211; 9215; 4551; 9216; 4552; 4631; 4511; 4092; 9219; 24678; 8632; 6908; 41768; 51255; 14594; 14598; 62979 +MAP2K6 MKK6 P52564 human P38A 81649 P70618 Mapk14 rat Y182 447971 TDDEMtGyVATRWYR Pkinase X 9211; 9215; 4551; 9216; 4552; 4631; 4511; 4092; 9219; 24678; 8632; 6908; 41768; 51255; 14594; 14598; 62979 +MAP2K6 MKK6 P52564 human P38D 5603 O15264 MAPK13 human T180 4787496 RHADAEMtGyVVtRW Pkinase X 9211; 9215; 4551; 9216; 4552; 4631; 4511; 4092; 9219; 24678; 8632; 6908; 41768; 51255; 14594; 14598; 62979 +MAP2K6 MKK6 P52564 human MKK6 5608 P52564 MAP2K6 human S207 448194 IsGyLVDsVAKtIDA Pkinase X 9231; 12280 +MAP2K6 MKK6 P52564 human MKK6 5608 P52564 MAP2K6 human Y219 1186001 IDAGCKPyMAPERIN Pkinase X +MAP2K6 MKK6 P52564 human P38A 1432 Q16539 MAPK14 human T180 447970 RHtDDEMtGyVAtRW Pkinase X X 9211; 9215; 4551; 9216; 4552; 4631; 4511; 4092; 9219; 24678; 8632; 6908; 41768; 51255; 14594; 14598; 62979 +MAP2K6 MKK6 P52564 human P38A 26416 P47811 Mapk14 mouse Y182 447971 tDDEMtGyVAtRWYR Pkinase X X 9211; 9215; 4551; 9216; 4552; 4631; 4511; 4092; 9219; 24678; 8632; 6908; 41768; 51255; 14594; 14598; 62979 +MAP2K6 MKK6 P52564 human P38D 26415 Q9Z1B7 Mapk13 mouse T180 4787496 RHTDTEMtGyVVTRW Pkinase X 9211; 9215; 4551; 9216; 4552; 4631; 4511; 4092; 9219; 24678; 8632; 6908; 41768; 51255; 14594; 14598; 62979 +MAP2K6 MKK6 P52564 human P38D 5603 O15264 MAPK13 human Y182 454935 ADAEMtGyVVtRWYR Pkinase X 9211; 9215; 4551; 9216; 4552; 4631; 4511; 4092; 9219; 24678; 8632; 6908; 41768; 51255; 14594; 14598; 62979 +MAP2K6 MKK6 P52564 human P38A 1432 Q16539 MAPK14 human Y182 447971 tDDEMtGyVAtRWYR Pkinase X X 9211; 9215; 4551; 9216; 4552; 4631; 4511; 4092; 9219; 24678; 8632; 6908; 41768; 51255; 14594; 14598; 62979 +Csk CSK P41241 mouse PECAM-1 18613 Q08481 Pecam1 mouse Y702 448760 TRATETVysEIRKVD X +Csk CSK P41241 mouse Lck 16818 P06240 Lck mouse Y505 447823 FTATEGQyQPQP___ X X 2751; 37458 +Csk CSK P41241 mouse LYN 17096 P25911 Lyn mouse Y508 447624 YtATEGQyQQQP___ X 2731 +Csk CSK P41241 mouse PECAM-1 18613 Q08481 Pecam1 mouse Y679 448759 PQNMDVEyTEVEVSS X +Csk CSK P41241 mouse Fyn 2534 P06241 FYN human Y531 447883 FtAtEPQyQPGENL_ X +Camkk1 CAMKK1 Q8VBY2 mouse CAMK1A 52163 Q91YS8 Camk1 mouse T177 448527 DPGSVLstACGtPGY Pkinase X +Camkk1 CAMKK1 Q8VBY2 mouse CAMK1D 227541 Q8BW96 Camk1d mouse T180 450469 GKGDVMstACGtPGY Pkinase X +Prkcb PKCB P68404 mouse PKCB 18751 P68404 Prkcb mouse S661 448672 QNEFAGFsyTNPEFV Pkinase_C X 9371 +Prkcb PKCB P68404 mouse TFEB 21425 Q9R210 Tfeb mouse S462 4785132 PEASKAssRRssFsM DUF3371 X +Prkcb PKCB P68404 mouse OSBPL9 114883 Q96SU4 OSBPL9 human S287 476780 PNTVPEFsYSSsEDE X X +Prkcb PKCB P68404 mouse PKCB 18751 P68404 Prkcb mouse T500 447896 WDGVttKtFCGtPDy Pkinase X 9379; 2060; 38938 +Prkcb PKCB P68404 mouse TNNI3 21954 P48787 Tnni3 mouse S24 448424 APVRRRssANyRAYA Troponin-I_N X +Prkcb PKCB P68404 mouse TFEB 21425 Q9R210 Tfeb mouse S461 4785127 sPEASKAssRRssFs DUF3371 X +Prkcb PKCB P68404 mouse PKCA 18750 P20444 Prkca mouse T497 448598 MDGVttRtFCGtPDy Pkinase X 9379; 2060; 38938 +Prkcb PKCB P68404 mouse Btk 12229 P35991 Btk mouse S180 447577 GsLKPGssHRKTKKP X 3537 +Prkcb PKCB P68404 mouse TNNI3 21954 P48787 Tnni3 mouse S23 448423 PAPVRRRssANyRAY Troponin-I_N X +Prkcb PKCB P68404 mouse GLRB 14658 P48168 Glrb mouse S425 2048205 NDFSIVGsLPRDFEL Neur_chan_memb X +Prkcb PKCB P68404 mouse Akt1 11651 P31750 Akt1 mouse S473 447855 RPHFPQFsysAsGtA Pkinase_C X 9271; 3787; 4060; 4051; 5102; 4058; 2336; 2337; 4075; 4070; 5012; 4071; 92982; 5315; 9563; 9018; 12694; 52240; 11962; 15116; 88106; 26580; 68035; 31957; 23430; 20235 +Prkcb PKCB P68404 mouse PKCB iso2 18751 P68404-2 Prkcb mouse S660 1869073011 QsEFEGFsFVNsEFL Pkinase_C X +Prkcb PKCB P68404 mouse GSK3A 50686 P18265 Gsk3a rat S21 448584 SGRARtssFAEPGGG X 9337; 9316; 9331; 9327; 8452; 8566 +Prkcb PKCB P68404 mouse occludin 18260 Q61146 Ocln mouse S489 6094300 RLKQVKGsADYKSKR Occludin_ELL X +EIF2AK4 GCN2 Q9P2K8 human GCN2 440275 Q9P2K8 EIF2AK4 human T899 455461 SDPSGHLtGMVGTAL Pkinase X 94668 +EIF2AK4 GCN2 Q9P2K8 human MARS 4141 P56192 MARS1 human S229 22496702 EEELATLsEEEIAMA X +EIF2AK4 GCN2 Q9P2K8 human MARS 4141 P56192 MARS1 human S472 22496703 LGRTLPGsDWTPNAQ tRNA-synt_1g X +EIF2AK4 GCN2 Q9P2K8 human MARS 4141 P56192 MARS1 human S662 22496701 NRAGMFVskFFGGYV X X +EIF2AK4 GCN2 Q9P2K8 human eIF2-alpha 13665 Q6ZWX6 Eif2s1 mouse S52 447635 MILLSELsRrrIRSI S1 X X 3597; 9721; 3398; 5199; 53085; 95797 +EIF2AK4 GCN2 Q9P2K8 human eIF2-alpha 1965 P05198 EIF2S1 human S52 447635 MILLsELsRRRIRsI S1 X 3597; 9721; 3398; 5199; 53085; 95797 +Sgk1 SGK1 Q9WVC6 mouse NEDD4L 23327 Q96PU5 NEDD4L human S342 453438 ssRLRsCsVtDAVAE X 12146 +Sgk1 SGK1 Q9WVC6 mouse SHANK2 iso7 171093 Q9QX74-7 Shank2 rat S477 33668500 GPRSRSPsLNRLGGA X +Sgk1 SGK1 Q9WVC6 mouse NLRP3 216799 Q8R4B8 Nlrp3 mouse S3 38492201 _____MTsVRCKLAQ X +Sgk1 SGK1 Q9WVC6 mouse iNOS 18126 P29477 Nos2 mouse S903 455638 ILKPRYYsISSSQDH FAD_binding_1 X +Sgk1 SGK1 Q9WVC6 mouse iNOS 18126 P29477 Nos2 mouse S733 455637 VFTMRLKsQQNLQSE FAD_binding_1 X +Sgk1 SGK1 Q9WVC6 mouse NEDD4L 23327 Q96PU5 NEDD4L human S448 453440 IRRPRsLssPtVtLS X 8063 +Sgk1 SGK1 Q9WVC6 mouse ROMK 56379 O88335 Kcnj1 mouse S25 449605 RQRARLVsKDGRCNI IRK X X +Sgk1 SGK1 Q9WVC6 mouse CREB 1385 P16220 CREB1 human S119 448228 EILsRRPsyRkILND pKID X 9187; 9196; 9198; 4095; 14228; 14001; 39561; 80120; 44864; 54960; 95995 +Sgk1 SGK1 Q9WVC6 mouse NEDD4L 23327 Q96PU5 NEDD4L human T367 453439 AGRARsstVtGGEEP X +Sgk1 SGK1 Q9WVC6 mouse TRPV4 59341 Q9HBA0 TRPV4 human S824 4777181 LRRDRWssVVPRVVE X +Sgk1 SGK1 Q9WVC6 mouse MKK4 26398 P47809 Map2k4 mouse S78 447655 IERLRTHsIESsGKL X 9155 +Sgk1 SGK1 Q9WVC6 mouse NDRG1 17988 Q62433 Ndrg1 mouse T346 454245 GtRsRsHtsEGPRsR X 3217; 5482; 6992; 7497; 8947; 89166 +FLT4 VEGFR3 P35916 human GLO1 2739 Q04760 GLO1 human Y136 463450 GIAVPDVysACkRFE Glyoxalase X X +MATK CTK P42679 human SHPS1 140885 P78324 SIRPA human Y453 1861200 EPNNHTEyASIQTSP X +MATK CTK P42679 human SHPS1 140885 P78324 SIRPA human Y429 458557 QDTNDItyADLNLPk X +MATK CTK P42679 human LYN 4067 P07948 LYN human Y508 447624 ytAtEGQyQQQP___ X 2731 +Epha2 EphA2 Q03145 mouse NLRP3 216799 Q8R4B8 Nlrp3 mouse Y132 1869022700 ICKKKKDyCKMYRRH X +Csnk2b CK2B P67871 mouse OLIG2 50913 Q9EQW6 Olig2 mouse S13 18357900 SLVSsRPssPEPDDL X +Pkn1 PKN1 P70268 mouse rabphilin 3A 19894 P47708 Rph3a mouse S271 455801 AGLRRANsVQAARPA X +Pkn1 PKN1 P70268 mouse CRYAB 12955 P23927 Cryab mouse S45 448748 FSTATSLsPFYLRPP Crystallin X +Pkn1 PKN1 P70268 mouse TRAF1 22029 P39428 Traf1 mouse S139 26331402 MALERNLsELQLQAA X +Pkn1 PKN1 P70268 mouse CRYAB 12955 P23927 Cryab mouse S59 448783 PSFLRAPsWIDtGLS X +Pkn1 PKN1 P70268 mouse rabphilin 3A 19894 P47708 Rph3a mouse S234 455904 GPPTRRAsEARMSTA X +VRK2 VRK2 Q86Y07 human coilin 8161 P38432 COIL human S184 11329300 NEEAKRKsPKKKEKC Coilin_N X +VRK2 VRK2 Q86Y07 human GAPDH 2597 P04406 GAPDH human S151 3178959 LkIIsNAsCttNCLA X +VRK2 VRK2 Q86Y07 human USP25 29761 Q9UHP3 USP25 human T680 27533602 QPLVGIEtLPPDLRD X +VRK2 VRK2 Q86Y07 human USP25 29761 Q9UHP3 USP25 human S745 40407602 PEyLEQPsRSDFSKH X +VRK2 VRK2 Q86Y07 human TKT 7086 P29401 TKT human T287 452283 skkkILAtPPQEDAP X +VRK2 VRK2 Q86Y07 human BAF 8815 O75531 BANF1 human S4 458302 ____MttsQkHRDFV BAF X +VRK2 VRK2 Q86Y07 human DTNBP1 84062 Q96EV8 DTNBP1 human S299 40721501 RAKPPsSssTCtDSA Dysbindin X X +VRK2 VRK2 Q86Y07 human BAF 8815 O75531 BANF1 human T3 7105313 _____MttsQkHRDF BAF X +VRK2 VRK2 Q86Y07 human PLK1 5347 P53350 PLK1 human T210 448139 YDGERKktLCGtPNy Pkinase X X 4354; 5472; 9062 +VRK2 VRK2 Q86Y07 human p53 22059 P02340 Tp53 mouse T21 447541 ELPLsQEtFsGLWKL P53_TAD X +VRK2 VRK2 Q86Y07 human USP25 29761 Q9UHP3 USP25 human T727 40407603 QkLRESEtSVTTAQA X +VRK2 VRK2 Q86Y07 human IKKB 3551 O14920 IKBKB human S177 447492 AkELDQGsLCtsFVG Pkinase X X 2078; 2697; 2694; 14938; 92255; 36516; 36214 +VRK2 VRK2 Q86Y07 human BAF 8815 O75531 BANF1 human T2 7105310 ______MttsQkHRD BAF X +VRK2 VRK2 Q86Y07 human IKKB 3551 O14920 IKBKB human S181 447489 DQGsLCtsFVGTLQy Pkinase X X 2697; 2694; 14938; 92255; 36516; 36214 +VRK2 VRK2 Q86Y07 human DTNBP1 84062 Q96EV8 DTNBP1 human S297 9320776 ELRAKPPsSssTCtD Dysbindin X X +Mapk10 JNK3 P49187 rat STMN2 84510 P21818 Stmn2 rat S62 450174 ELILKPPsPISEAPR Stathmin X +Mapk10 JNK3 P49187 rat STMN2 84510 P21818 Stmn2 rat S73 450173 EAPRTLAsPKKkDLs Stathmin X +PFKP PFKP Q01813 human ATG4B 23192 Q9Y4P1 ATG4B human S34 4750282 WILGRKYsIFTEkDE X +ROCK1 ROCK1 Q13464 human eNOS 4846 P29474 NOS3 human T495 447885 TGITRKKtFKEVANA X 9574 +ROCK1 ROCK1 Q13464 human Radixin 5962 P35241 RDX human T564 448374 AGRDKyKtLRQIRQG ERM_C X 3141; 3726; 32600 +ROCK1 ROCK1 Q13464 human TSC2 24855 P49816 Tsc2 rat T1203 19075303 EILVRRPtGNTSWLM X +ROCK1 ROCK1 Q13464 human NHE1 6548 P19634 SLC9A1 human T653 4729330 LRsYNRHtLVADPyE NEXCaM_BD X +ROCK1 ROCK1 Q13464 human GRF-1 2909 Q9NRY4 ARHGAP35 human T1173 3213723 GRFASYRtsFsVGsD RhoGAP_pG1_pG2 X +ROCK1 ROCK1 Q13464 human FHOD1 29109 Q9Y613 FHOD1 human S1137 2035403 RsRGNRKsLRRtLKs X X +ROCK1 ROCK1 Q13464 human ARHGAP24 83478 Q8N264 ARHGAP24 human S391 484901 RsSMNNGsPtALSGs X +ROCK1 ROCK1 Q13464 human FHOD1 29109 Q9Y613 FHOD1 human T1141 2035402 NRKsLRRtLKsGLGD X X +ROCK1 ROCK1 Q13464 human Ezrin 7430 P15311 EZR human T567 448104 QGRDkyKtLRQIRQG ERM_C X X 3141; 3726; 32600 +ROCK1 ROCK1 Q13464 human GFAP 2670 P14136 GFAP human S38 449621 LGPGTRLsLARMPPP Filament_head X X +ROCK1 ROCK1 Q13464 human PTEN 5728 P60484 PTEN human S229 456213 VkIYSsNsGPtRRED PTEN_C2 X X +ROCK1 ROCK1 Q13464 human GRF-1 2909 Q9NRY4 ARHGAP35 human S1236 7159801 PKPKPRPsITKATWE RhoGAP_pG1_pG2 X +ROCK1 ROCK1 Q13464 human Vimentin 22352 P20152 Vim mouse S72 449026 ssAVRLRssVPGVRL Filament_head X +ROCK1 ROCK1 Q13464 human desmin 1674 P17661 DES human T17 449613 RVssYRRtFGGAPGF Filament_head X X +ROCK1 ROCK1 Q13464 human AQP2 359 P41181 AQP2 human T269 3339002 PQsLPRGtkA_____ X X +ROCK1 ROCK1 Q13464 human FHOD1 29109 Q9Y613 FHOD1 human S1131 451843 AARERKRsRGNRKsL X X +ROCK1 ROCK1 Q13464 human PRMT5 10419 O14744 PRMT5 human T80 62906108 LsGRDWNtLIVGkLS PRMT5_TIM X +ROCK1 ROCK1 Q13464 human MRLC1 296313 Q64122 Myl9 rat S20 1863500 KRPQSAtsNVFAMFD X X 3674; 3671; 3675; 95777 +ROCK1 ROCK1 Q13464 human RhoE 390 P61587 RND3 human S11 455489 RRAsQkLsSksIMDP X X +ROCK1 ROCK1 Q13464 human MRLC1 10398 P24844 MYL9 human T19 1863501 KKRPQRAtsNVFAMF X 3674; 95777 +ROCK1 ROCK1 Q13464 human desmin 1674 P17661 DES human S60 449614 VyQVsRtsGGAGGLG Filament_head X +ROCK1 ROCK1 Q13464 human KCNK3 3777 O14649 KCNK3 human S336 21336507 IPRDLStsDTCVEQS X +ROCK1 ROCK1 Q13464 human ARHGAP24 83478 Q8N264 ARHGAP24 human T452 12518705 GLEKTQTtPNGSLQA X +ROCK1 ROCK1 Q13464 human profilin 1 5216 P07737 PFN1 human S138 2850008 MAsHLRRsQy_____ Profilin X X +ROCK1 ROCK1 Q13464 human RhoE 390 P61587 RND3 human S218 25307985 QRATKRIsHMPsRPE X X +ROCK1 ROCK1 Q13464 human H3 8350 P68431 H3C1 human S10 455676 tkQtArkstGGkAPr Histone X X 9701; 9711; 9606; 3465; 3642; 3377; 3475; 3458; 5764; 47398; 8481; 8552; 53348; 29237; 66065; 43185; 64522; 52725 +ROCK1 ROCK1 Q13464 human calponin 1 396522 P26932 CNN1 chicken T259 469596 GASQQGMtVYGLPRQ Calponin X +ROCK1 ROCK1 Q13464 human calponin 3 71994 Q9DAW9 Cnn3 mouse S293 4776192 QGtGTNGsEIsDsDy X +ROCK1 ROCK1 Q13464 human ARHGAP24 83478 Q8N264 ARHGAP24 human S437 12518706 SGIVTNGsFSSSNAE X +ROCK1 ROCK1 Q13464 human RhoE 390 P61587 RND3 human S7 455488 _MKERRAsQkLsSks X +ROCK1 ROCK1 Q13464 human APP iso2 11820 P12023-2 App mouse S655 448200 LkkkQyTsIHHGVVE APP_amyloid X +ROCK1 ROCK1 Q13464 human Moesin 17698 P26041 Msn mouse T558 447706 LGRDKYKtLRQIRQG ERM_C X 3141; 3726; 32600 +ROCK1 ROCK1 Q13464 human LIMK2 3985 P53671 LIMK2 human T505 448683 NDRKKRYtVVGNPYW PK_Tyr_Ser-Thr X 3841 +ROCK1 ROCK1 Q13464 human calponin 1 396522 P26932 CNN1 chicken S175 450890 MGtNKFAsQQGMtAY Calponin X +ROCK1 ROCK1 Q13464 human GRF-1 2909 Q9NRY4 ARHGAP35 human S1174 7157500 RFASYRtsFsVGsDD RhoGAP_pG1_pG2 X +ROCK1 ROCK1 Q13464 human H3 8350 P68431 H3C1 human S28 455677 ATkAArksAPATGGV Histone X 9713 +ROCK1 ROCK1 Q13464 human MRLC1 296313 Q64122 Myl9 rat T19 1863501 KKRPQSAtsNVFAMF X 3674; 95777 +ROCK1 ROCK1 Q13464 human Vimentin 7431 P08670 VIM human S72 449026 ssAVrLrssVPGVRL Filament_head X X +ROCK1 ROCK1 Q13464 human GFAP 2670 P14136 GFAP human S13 449619 ItsAArrsyVSsGEM Filament_head X X +ROCK1 ROCK1 Q13464 human desmin 1674 P17661 DES human T76 449615 LRAsRLGttRtPssy Filament_head X +ROCK1 ROCK1 Q13464 human MYPT1 396020 Q90623 PPP1R12A chicken T850 452075 PREKRRstGVSFWTQ X X +ROCK1 ROCK1 Q13464 human calponin 1 396522 P26932 CNN1 chicken T184 469595 QGMtAYGtRRHLYDP Calponin X +ROCK1 ROCK1 Q13464 human FAK 5747 Q05397 PTK2 human S732 450196 SsEGFYPsPQHMVQT X +ROCK1 ROCK1 Q13464 human PAR-4 5074 Q96IZ0 PAWR human T163 456964 LREKRRstGVVNIPA X 2329 +ROCK1 ROCK1 Q13464 human SOX9 6662 P48436 SOX9 human S181 456981 YQPRRRKsVKNGQAE X X +ROCK1 ROCK1 Q13464 human MYPT1 4659 O14974 PPP1R12A human T853 452075 PREKRRstGVsFWtQ X X 4563 +ROCK1 ROCK1 Q13464 human calponin 1 396522 P26932 CNN1 chicken T180 469594 FAsQQGMtAYGtRRH Calponin X +ROCK1 ROCK1 Q13464 human MYPT1 4659 O14974 PPP1R12A human T696 448587 ARQsRRstQGVtLtD X X 5163 +ROCK1 ROCK1 Q13464 human calponin 3 71994 Q9DAW9 Cnn3 mouse S296 4776198 GTNGsEIsDsDyQAE X +ROCK1 ROCK1 Q13464 human JIP3 23162 Q9UPT6 MAPK8IP3 human S365 486175 RLDRtGssPTQGIVN X X +ROCK1 ROCK1 Q13464 human Scribble 23513 Q14160 SCRIB human S1508 480131 WRAARMksLEQDALR X X +ROCK1 ROCK1 Q13464 human calponin 1 396522 P26932 CNN1 chicken T170 469593 IIGLQMGtNKFAsQQ Calponin X +ROCK1 ROCK1 Q13464 human MARCKS 4082 P29966 MARCKS human S159 447786 kkKKKRFsFkKsFkL MARCKS X 2741; 11992 +ROCK1 ROCK1 Q13464 human RhoE 390 P61587 RND3 human S240 27933601 LRKDKAKsCTVM___ X X +ROCK1 ROCK1 Q13464 human MYPT1 17931 Q9DBR7 Ppp1r12a mouse T694 448587 ARQSRRstQGVTLTD X 5163 +ROCK1 ROCK1 Q13464 human TPPP 11076 O94811 TPPP human S107 31094519 FSKIKGKsCRTITFE p25-alpha X +ROCK1 ROCK1 Q13464 human GFAP 2670 P14136 GFAP human T7 449617 _MERRRItsAArrsy Filament_head X X +ROCK1 ROCK1 Q13464 human GRF-1 2909 Q9NRY4 ARHGAP35 human S1150 457041 LERGRKVsIVsKPVL RhoGAP_pG1_pG2 X X +ROCK1 ROCK1 Q13464 human ARHGAP24 83478 Q8N264 ARHGAP24 human S415 4757012 HKLDVsRsPPLMVkk X +ROCK1 ROCK1 Q13464 human MYPT1 396020 Q90623 PPP1R12A chicken T695 448587 ARQSRRstQGVTLTD X 5163 +ROCK1 ROCK1 Q13464 human ARHGAP19 84986 Q14CB8 ARHGAP19 human S422 3196670 QkRARsRsFsGLIkR X +ROCK1 ROCK1 Q13464 human PAR3-alpha 81918 Q9Z340 Pard3 rat T833 2512944 QsMSEKRtKQFSNAS X +ROCK1 ROCK1 Q13464 human MRLC2 103910 O14950 MYL12B human S20 448595 KRPQRAtsNVFAMFD X X +ROCK1 ROCK1 Q13464 human CRMP-2 1808 Q16555 DPYSL2 human T555 448084 DNIPRRttQRIVAPP X X +ROCK1 ROCK1 Q13464 human TPPP 11076 O94811 TPPP human S159 487537 sGVtKAIssPtVSRL p25-alpha X +ROCK1 ROCK1 Q13464 human GRF-1 2909 Q9NRY4 ARHGAP35 human T1226 7159800 LRsLRRNtKKPKPKP RhoGAP_pG1_pG2 X +ROCK1 ROCK1 Q13464 human ADD1 118 P35611 ADD1 human T445 449480 QkQQREKtRWLNSGR X X +ROCK1 ROCK1 Q13464 human GR 2908 P04150 NR3C1 human T519 1872513502 SENPGNKtIVPAtLP X +ROCK1 ROCK1 Q13464 human MRLC1 10398 P24844 MYL9 human S20 1863500 KRPQRAtsNVFAMFD X X 3674; 3671; 3675; 95777 +ROCK1 ROCK1 Q13464 human desmin 1674 P17661 DES human T77 449616 RAsRLGttRtPssyG Filament_head X +ROCK1 ROCK1 Q13464 human ADD1 118 P35611 ADD1 human T480 449481 TKEDGHRtstsAVPN X X +ROCK1 ROCK1 Q13464 human Scribble 23513 Q14160 SCRIB human S1378 470678 EGPPKRVsLVGADDL X X +ROCK1 ROCK1 Q13464 human Moesin 4478 P26038 MSN human T558 447706 LGRDKyKtLRQIRQG ERM_C X X 3141; 3726; 32600 +ROCK1 ROCK1 Q13464 human NFL 281348 P02548 NEFL cow S27 457196 ETPRVHIsSVRSGYS Filament_head X +ROCK1 ROCK1 Q13464 human GR 2908 P04150 NR3C1 human S617 1872513503 WRSYRQSsANLLCFA Hormone_recep X +ROCK1 ROCK1 Q13464 human MYPT1 396020 Q90623 PPP1R12A chicken S849 451999 RPREKRRstGVSFWT X +ROCK1 ROCK1 Q13464 human AQP2 11827 P56402 Aqp2 mouse S269 3339002 PQsLPRGskA_____ X +ROCK1 ROCK1 Q13464 human MRLC2 531505 Q5E9E2 MYL12A cow S20 448595 KRPQRAtsNVFAMFD X +ROCK1 ROCK1 Q13464 human PPP1R12B 4660 O60237 PPP1R12B human T646 478177 ARQtRRstQGVtLtD X X +ROCK1 ROCK1 Q13464 human ARHGAP24 83478 Q8N264 ARHGAP24 human S413 12518707 sVHKLDVsRsPPLMV X +ROCK1 ROCK1 Q13464 human DAPK3 1613 O43293 DAPK3 human T265 454892 KDPKRRMtIAQSLEH Pkinase X X +ROCK1 ROCK1 Q13464 human MRLC2 103910 O14950 MYL12B human T19 448596 KKRPQRAtsNVFAMF X X +ROCK1 ROCK1 Q13464 human NFL 281348 P02548 NEFL cow S58 457405 LSVRRsYsSSSGsLM Filament_head X +ROCK1 ROCK1 Q13464 human ARHGAP24 83478 Q8N264 ARHGAP24 human S402 4757006 LSGsKTNsPKNsVHK X +ROCK1 ROCK1 Q13464 human desmin 1674 P17661 DES human S12 449612 ysSSQRVssYRRtFG Filament_head X +ROCK1 ROCK1 Q13464 human LIMK1 3984 P53667 LIMK1 human T508 447808 PDRKKRYtVVGNPYW PK_Tyr_Ser-Thr X X 3841 +ROCK1 ROCK1 Q13464 human DAPK3 1613 O43293 DAPK3 human T299 454893 PERRRLKtTRLkEyt X +ROCK1 ROCK1 Q13464 human TIAM2 24001 Q6ZPF3 Tiam2 mouse T1662 478913 STKRGRGtLLKAQTR X +ROCK1 ROCK1 Q13464 human MRLC2 531505 Q5E9E2 MYL12A cow T19 448596 KKRPQRAtsNVFAMF X +ROCK1 ROCK1 Q13464 human MYPT1 17931 Q9DBR7 Ppp1r12a mouse T852 452075 PREKRRstGVSFWtQ X 4563 +ROCK1 ROCK1 Q13464 human JIP3 23162 Q9UPT6 MAPK8IP3 human S314 26340500 RAREKRDsRNMEVQV X X +ROCK1 ROCK1 Q13464 human TPPP 11076 O94811 TPPP human S32 456613 DRAAKRLsLEsEGAG X +ROCK1 ROCK1 Q13464 human JIP3 23162 Q9UPT6 MAPK8IP3 human S364 2025497 TRLDRtGssPTQGIV X X +ROCK1 ROCK1 Q13464 human PTEN 5728 P60484 PTEN human T232 456214 YSsNsGPtRREDKFM PTEN_C2 X X +ROCK1 ROCK1 Q13464 human KCNK3 3777 O14649 KCNK3 human S393 2840504 GLMKRRssV______ X +ROCK1 ROCK1 Q13464 human MYPT1 4659 O14974 PPP1R12A human S852 451999 RPREKRRstGVsFWt X +Map3k7 TAK1 Q62073 mouse RIPK1 19766 Q60855 Ripk1 mouse S321 468644 PVLQRMFsLQHDCVP X 83613; 38662 +Map3k7 TAK1 Q62073 mouse RIPK1 19766 Q60855 Ripk1 mouse S334 4728178 VPLPPsRsNsEQPGS X +Map3k7 TAK1 Q62073 mouse SQSTM1 18412 Q64337 Sqstm1 mouse S351 14580829 SsKEVDPsTGELQsL X 95697; 16177; 12074 +Map3k7 TAK1 Q62073 mouse TAK1 6885 O43318 MAP3K7 human T187 454704 CDIQtHMtNNKGsAA PK_Tyr_Ser-Thr X 4536; 4531; 4508 +Map3k7 TAK1 Q62073 mouse RIPK1 19766 Q60855 Ripk1 mouse S332 4728172 DCVPLPPsRsNsEQP X +Map3k7 TAK1 Q62073 mouse KSR 16706 Q61097 Ksr1 mouse S392 449297 ARLRRtEsVPsDINN X X 4951 +Map3k7 TAK1 Q62073 mouse TAK1 26409 Q62073 Map3k7 mouse S192 448289 HMtNNKGsAAWMAPE PK_Tyr_Ser-Thr X X +CERT1 COL4A3BP Q9Y5P4 human COL4A3 1285 Q01955 COL4A3 human S1435 1247500 LKGKRGDsGSPATWT Collagen X +PKM PKM iso2 P14618-2 human BUB3 9184 O43684 BUB3 human Y207 463080 EGRVAVEyLDPsPEV X X +PKM PKM iso2 P14618-2 human H3 8350 P68431 H3C1 human T11 455680 kQtArkstGGkAPrk Histone X X 9767; 9764 +PKM PKM iso2 P14618-2 human STAT3 6774 P40763 STAT3 human Y705 448192 DPGsAAPyLktKFIC X 4093; 9145; 4324; 9131; 9138; 4323; 4074; 4113; 48313; 20977; 25023; 8119; 52075; 52527; 73533; 61958; 73452; 16185; 74309 +NEK5 NEK5 Q6P3R8 human TTLL4 67534 Q80UG8 Ttll4 mouse S1136 36123708 KKsQAGLsPIsRKTL X +NEK5 NEK5 Q6P3R8 human TTLL4 67534 Q80UG8 Ttll4 mouse T813 1873647200 YSVNKKNtEyQANAD TTL X +NEK5 NEK5 Q6P3R8 human TTLL4 9654 Q14679 TTLL4 human S912 1873645600 LEVNISPsLHSSSPL TTL X +NEK5 NEK5 Q6P3R8 human TTLL4 67534 Q80UG8 Ttll4 mouse Y815 1873647202 VNKKNtEyQANADET TTL X +NEK5 NEK5 Q6P3R8 human TTLL4 67534 Q80UG8 Ttll4 mouse S1139 1873647208 QAGLsPIsRKTLSSR X +NEK5 NEK5 Q6P3R8 human TTLL4 67534 Q80UG8 Ttll4 mouse T968 1873647206 PRDKCQMtPEHFTAQ X +FER Fer P16591 human PKCD 5580 Q05655 PRKCD human Y374 464424 ELkGRGEyFAIKALK Pkinase X X +FER Fer P16591 human CRMP-2 1808 Q16555 DPYSL2 human Y499 463170 rGVPRGLyDGPVCEV X +FER Fer P16591 human Met 4233 P08581 MET human Y1349 448472 stFIGEHyVHVNAty X 3133; 3121 +FER Fer P16591 human Fer 2241 P16591 FER human Y402 457934 EPPPVVNyEEDARsV X +FER Fer P16591 human Cortactin 13043 Q60598 Cttn mouse Y421 447702 RPPssPIyEDAAPFK X 4569 +FER Fer P16591 human IRS4 8471 O14654 IRS4 human Y921 456294 EADSSsDyVNMDFTk X +FER Fer P16591 human IRS4 8471 O14654 IRS4 human Y828 456293 GQNDNsEyVPMLPGk X +FER Fer P16591 human PTP1B 395688 O13016 PTPN1 chicken Y152 449312 ISEDIKSyyTVRQLE Y_phosphatase X +FER Fer P16591 human Cortactin 13043 Q60598 Cttn mouse Y482 447704 yQAEDDTyDGYESDL X +FER Fer P16591 human STAT3 6774 P40763 STAT3 human Y705 448192 DPGsAAPyLktKFIC X 4093; 9145; 4324; 9131; 9138; 4323; 4074; 4113; 48313; 20977; 25023; 8119; 52075; 52527; 73533; 61958; 73452; 16185; 74309 +FER Fer P16591 human Fer 2241 P16591 FER human Y615 6311907 EAkILkQyDHPNIVK PK_Tyr_Ser-Thr X +FER Fer P16591 human IRS4 8471 O14654 IRS4 human Y847 1877150802 GLDkEVSyNWDPKDA X +FER Fer P16591 human Ezrin 7430 P15311 EZR human Y478 454875 PPPPPPVyEPVsyHV X +FER Fer P16591 human SKOR1 207667 Q8BX46 Skor1 mouse Y234 1881001402 HRTPDAKyTQPDAAN X X +FER Fer P16591 human AR 367 P10275 AR human Y225 1243004 PtsSKDNyLGGTSTI Androgen_recep X X +FER Fer P16591 human IRS4 8471 O14654 IRS4 human Y656 1877150800 SGGRFRLyFCVDrGA X +FER Fer P16591 human PECAM-1 18613 Q08481 Pecam1 mouse Y679 448759 PQNMDVEyTEVEVSS X +FER Fer P16591 human IRS4 8471 O14654 IRS4 human Y779 10781335 DNDsEsDyMFMAPGA X +FER Fer P16591 human CTNNB1 12387 Q02248 Ctnnb1 mouse Y142 449044 AVVNLINyQDDAELA X +FER Fer P16591 human CRMP-2 1808 Q16555 DPYSL2 human Y479 18833900 kPFPDFVyKRIKARS X X +FER Fer P16591 human Ezrin 7430 P15311 EZR human Y354 448105 LMLRLQDyEEktKKA ERM_helical X 3144; 5484 +FER Fer P16591 human ERK2 5594 P28482 MAPK1 human Y187 447594 HtGFLtEyVAtRWyr Pkinase X X 9106; 4370; 4374; 9101; 4375; 4376; 4377; 3510; 5726; 88569; 13214; 13148; 70235; 9488; 89967; 8544; 14196; 14227; 14095; 14474; 75165; 98168; 33370; 54240; 15892; 45899; 55088; 9524; 69217; 48735 +FER Fer P16591 human Cortactin 13043 Q60598 Cttn mouse Y466 447703 TyTSEPVyETTEAPG X +FER Fer P16591 human NSF 4905 P46459 NSF human Y83 453414 QEIEVSLyTFDKAKQ CDC48_N X +FER Fer P16591 human Fer 2241 P16591 FER human Y714 448461 RQEDGGVyssSGLkQ PK_Tyr_Ser-Thr X +FER Fer P16591 human Ezrin 7430 P15311 EZR human Y146 448758 kEVHksGyLSsERLI FERM_M X +FER Fer P16591 human CTNNG 3728 P14923 JUP human Y550 456972 AAGtQQPytDGVRME X +FER Fer P16591 human GAB1 2549 Q13480 GAB1 human Y627 447948 KGDKQVEyLDLDLDs X 3231; 3233 +PRKG2 PKG2 Q13237 human eNOS 4846 P29474 NOS3 human T495 447885 TGITRKKtFKEVANA X 9574 +PRKG2 PKG2 Q13237 human NHE3 100009430 P26432 NHE-3 rabbit S663 457469 TMRKRLEsFKSAKLG X +PRKG2 PKG2 Q13237 human STAR 25557 P97826 Star rat S99 450441 QEGWKKEsQQENGDE START X +PRKG2 PKG2 Q13237 human GCAP2 286851 P51177 GUCA1B cow S201 455322 ISQQRRKsAMF____ X +PRKG2 PKG2 Q13237 human SHP-1 5777 P29350 PTPN6 human S557 11086952 AKAsRtssKHkEDVy X +PRKG2 PKG2 Q13237 human STAR 25557 P97826 Star rat S55 450439 MGQVRRRssLLGSQL X +PRKG2 PKG2 Q13237 human PDGFRB 5159 P09619 PDGFRB human S712 23130549 sDkRRPPsAELysNA PK_Tyr_Ser-Thr X +PRKG2 PKG2 Q13237 human MRF 225908 Q3UR85 Myrf mouse S259 20804942 PSKKRKHsEsPPNTL X +PRKG2 PKG2 Q13237 human ICLN 403971 P35521 CLNS1A dog S2 6745600 ______MsFLKSFPP X +PRKG2 PKG2 Q13237 human STAR 25557 P97826 Star rat S56 450440 GQVRRRssLLGSQLE X +PRKG2 PKG2 Q13237 human HCN2 15166 O88703 Hcn2 mouse S641 18454000 DRIGKKNsILLHKVQ X +PRKG2 PKG2 Q13237 human EGFR 1956 P00533 EGFR human T430 1876620106 LEIIRGRtKQHGQFS Recep_L_domain X X +PRKG2 PKG2 Q13237 human PDGFRB 5159 P09619 PDGFRB human S254 1876167502 WTYPRKEsGRLVEPV Ig_3 X +PRKG2 PKG2 Q13237 human CTH 1491 P32929 CTH human S377 484505 SDTLIRLsVGLEDEE Cys_Met_Meta_PP X +PRKG2 PKG2 Q13237 human ICLN 403971 P35521 CLNS1A dog S93 6745601 FGEESKEsVAEEEDS Voldacs X +PRKG2 PKG2 Q13237 human NHE3 100009430 P26432 NHE-3 rabbit S554 450899 TEGERRGsLAFIRSP X X +PRKG2 PKG2 Q13237 human HER2 2064 P04626 ERBB2 human T686 451817 QQKIRKYtMRRLLQE X 88583 +PRKG2 PKG2 Q13237 human SHP-1 5777 P29350 PTPN6 human S556 15406102 HAKAsRtssKHkEDV X +PRKG2 PKG2 Q13237 human mAChR M3 P41984 CHRM3 cow S482 23940032 ITKRKRMsLIKEKKA 7tm_1 X +PRKG2 PKG2 Q13237 human NHE3 100009430 P26432 NHE-3 rabbit S607 450900 SLEQRRRsVRDAEDV X X +PRKG2 PKG2 Q13237 human eNOS 4846 P29474 NOS3 human S1177 447884 TSRIRtQsFsLQERQ X 9571; 9570 +PRKG2 PKG2 Q13237 human eNOS 4846 P29474 NOS3 human S633 448637 WRRKRKEssNtDsAG Flavodoxin_1 X +PRKG2 PKG2 Q13237 human Lasp-1 3927 Q14847 LASP1 human S146 448836 MEPERRDsQDGssyR X +PRKG2 PKG2 Q13237 human EGFR 1956 P00533 EGFR human T693 448054 RELVEPLtPsGEAPN X 3056; 8808 +PRKG2 PKG2 Q13237 human ICLN 403971 P35521 CLNS1A dog S45 456841 YIAESRLsWLDGSGL Voldacs X +PRKG2 PKG2 Q13237 human SHP-1 5777 P29350 PTPN6 human S553 15415001 kNAHAKAsRtssKHk X +PRKG2 PKG2 Q13237 human PTS 5805 Q03393 PTS human S19 450662 AQVSRRIsFSASHRL PTPS X X +PRKG2 PKG2 Q13237 human Met 4233 P08581 MET human S985 450188 PHLDRLVsARsVsPt X +PRKG1 PKG1 P00516 cow GluR2 29627 P19491 Gria2 rat S697 10306402 KMWTYMRsAEPSVFV Lig_chan X +PRKG1 PKG1 P00516 cow PTRF 287710 P85125 Cavin1 rat T304 2566127 DKLRKsFtPDHVVyA PTRF_SDPR X +PRKG1 PKG1 P00516 cow CACNA1C 100101555 P15381 CACB rabbit S1928 455278 ASLGRRAsFHLECLK CAC1F_C X +PRKG1 PKG1 P00516 cow GSBS 10842 O96001 PPP1R17 human T68 2999005 KKPRRKDtPALHIPP X +PRKG1 PKG1 P00516 cow Arp3 81732 Q4V7C7 Actr3 rat T257 2566207 SkWIkQYtGVNAISK Actin X +PRKG1 PKG1 P00516 cow GCAP2 286851 P51177 GUCA1B cow S201 455322 ISQQRRKsAMF____ X +PRKG1 PKG1 P00516 cow PKG1 282004 P00516 PRKG1 cow T85 452151 RQAFRKFtKSERSKD X +PRKG1 PKG1 P00516 cow HMGN1 614915 P02316 HMGN1 cow S25 454112 KRRSARLsAKPAPAK HMG14_17 X +PRKG1 PKG1 P00516 cow CACNB2 100009277 P54288 CAB2 rabbit S522 486359 SGTSRGLsRQETFDS X +PRKG1 PKG1 P00516 cow MRVI1 10335 Q9Y6F6 IRAG1 human S689 485352 NMPRRRVsVAVVPKF MRVI1 X +PRKG1 PKG1 P00516 cow smMLCK 100009143 P29294 MYLK rabbit S1011 468782 SsTGSPTsPLTAERL X +PRKG1 PKG1 P00516 cow GSBS 10842 O96001 PPP1R17 human T119 2999004 kKPRRKDtPALHMSP X +PRKG1 PKG1 P00516 cow PKG1 282004 P00516 PRKG1 cow S27 452152 KELEKRLsEKEEEIQ PKcGMP_CC X +PRKG1 PKG1 P00516 cow CACNA1C 100101555 P15381 CACB rabbit S533 453091 RIsKSKFsRYWRRWN X +PRKG1 PKG1 P00516 cow SF1 117855 NP_001104263 Sf1 rat S20 449919 PSkKRKRsRWNQDTM SF1-HH X +PRKG1 PKG1 P00516 cow H2B 615043 P62808 H2BC19 cow S32 447801 DGKKRKRsRKEsYSV Histone X +PRKG1 PKG1 P00516 cow PTRF 287710 P85125 Cavin1 rat S368 452129 TDLLRGssPDVHTLL X +PRKG1 PKG1 P00516 cow DMN 308709 Q810D0 Synm rat S777 2565443 EVDDVsPsPKGFIEE X +PRKG1 PKG1 P00516 cow MDH1 24551 O88989 Mdh1 rat S241 1210666 VIkARKLsSAMSAAK Ldh_1_C X +PRKG1 PKG1 P00516 cow GKAP1 56278 Q9JMB0 Gkap1 mouse S106 12524600 PNPAQKEsREENWQE X X +PRKG1 PKG1 P00516 cow PKG1 282004 P00516 PRKG1 cow T59 448837 THIGPRTtRAQGIsA X +PRKG1 PKG1 P00516 cow PDE5A 8654 O76074 PDE5A human S102 448178 GTPTRKIsAsEFDRP X +PRKG1 PKG1 P00516 cow VASP 7408 P50552 VASP human S239 448380 GAKLRKVsKQEEASG X 3114; 37565 +PRKG1 PKG1 P00516 cow smMLCK 100009143 P29294 MYLK rabbit S1005 455821 GLSGRKSsTGSPTsP X +PRKG1 PKG1 P00516 cow PKAR1A 615074 P00514 PRKAR1A cow S100 454354 RRRRGAIsAEVYTEE X +PRKG1 PKG1 P00516 cow HMGN1 614915 P02316 HMGN1 cow S7 447788 _MPKRKVsSAEGAAK HMG14_17 X +PRKG1 PKG1 P00516 cow PTRF 287710 P85125 Cavin1 rat S302 465873 SRDKLRKsFtPDHVV PTRF_SDPR X +PRKG1 PKG1 P00516 cow SEPT3 56003 Q9WU34 Septin3 rat S91 453431 SQVSRKAsSWNREEK Septin X +PRKG1 PKG1 P00516 cow PKG1 282004 P00516 PRKG1 cow S51 452149 QsVLPVPsTHIGPRT X +PRKG1 PKG1 P00516 cow HMGN2 P02313 HMGN2 cow S29 2574920 QRRSARLsAKPAPPK HMG14_17 X +PRKG1 PKG1 P00516 cow RIL 24915 P36202 Pdlim4 rat S119 468635 PATsRRssIsGIsLE X +PRKG1 PKG1 P00516 cow H1C 513971 P02253 H1-2 cow S36 450120 AGARRKAsGPPVSEL X +PRKG1 PKG1 P00516 cow CACNA1C 100101555 P15381 CACB rabbit S528 486358 ARLAHRIsKSKFsRY X +PRKG1 PKG1 P00516 cow CFTR 1080 P13569 CFTR human S660 449979 FSAERRNsILTETLH CFTR_R X +PRKG1 PKG1 P00516 cow MCAM 78967 Q9EPF2 Mcam rat S426 2565319 LNRTRRVsVGIFGSP X +PRKG1 PKG1 P00516 cow PKG1 282004 P00516 PRKG1 cow S45 452150 RKLHKCQsVLPVPsT X +PRKG1 PKG1 P00516 cow PKG1 282004 P00516 PRKG1 cow S65 452147 TtRAQGIsAEPQTYR X +PRKG1 PKG1 P00516 cow smMLCK 288057 D3ZFU9 Mylk rat S1816 455821 GLsGRKSsTGsPTsP X +PRKG1 PKG1 P00516 cow AKAP12 83425 Q5QD51 Akap12 rat S614 476343 KKRVRRPsESDKEEE WSK X +PRKG1 PKG1 P00516 cow Titin iso2 84015 Q7TMZ9 Ttn rat S935 2312300 GNGKAMTsAKLTVGE I-set X +PRKG1 PKG1 P00516 cow SERPINA1 24648 P17475 Serpina1 rat S45 2565355 SPTYRKIsSNLADFA X +PRKG1 PKG1 P00516 cow CFTR 1080 P13569 CFTR human S700 449978 FGEKRkNsILNPINs CFTR_R X +PRKG1 PKG1 P00516 cow H2B 615043 P62808 H2BC19 cow S36 449903 RKRsRKEsYSVYVYK Histone X +PRKG1 PKG1 P00516 cow PTRF 287710 P85125 Cavin1 rat S367 452128 ETDLLRGssPDVHTL X +PRKG1 PKG1 P00516 cow PKG1 282004 P00516 PRKG1 cow T517 452153 GFGKKTWtFCGTPEY Pkinase X +PRKG1 PKG1 P00516 cow PKG1 282004 P00516 PRKG1 cow S73 452148 AEPQTYRsFHDLRQA X +PRKG1 PKG1 P00516 cow VASP 7408 P50552 VASP human S157 448379 EHIERRVsNAGGPPA X 3111; 84519 +PRKG1 PKG1 P00516 cow HSP20 126393 O14558 HSPB6 human S16 450706 PSWLRRAsAPLPGLS Crystallin X 36519 +PRKG1 PKG1 P00516 cow RIL 24915 P36202 Pdlim4 rat S118 481133 sPATsRRssIsGIsL X +CKB CKB P05122 chicken CKB 396248 P05122 CKB chicken T289 451826 tCPsNLGtGLRAGVH ATP-gua_Ptrans X +CKB CKB P05122 chicken CKB 396248 P05122 CKB chicken T282 451824 PHLGYILtCPsNLGt ATP-gua_Ptrans X +CKB CKB P05122 chicken CKB 396248 P05122 CKB chicken S285 451825 GYILtCPsNLGtGLR ATP-gua_Ptrans X +Ptk2b Pyk2 P70600 rat GJA1 24392 P08050 Gja1 rat Y313 454254 sEQNWANysAEQNRM Connexin43 X X +Ptk2b Pyk2 P70600 rat GJA1 24392 P08050 Gja1 rat Y265 447815 kDCGsPkyAyFNGCS X X +Ptk2b Pyk2 P70600 rat Hic-5 7041 O43294 TGFB1I1 human Y60 450964 SGDKDHLystVCKPR Paxillin X +Ptk2b Pyk2 P70600 rat PXN 360820 Q66H76 Pxn rat Y31 448785 FLSEEPPySYPTGNH X +Ptk2b Pyk2 P70600 rat Src 83805 Q9WUD9 Src rat Y419 448234 RLIEDNEyTARQGAk PK_Tyr_Ser-Thr X 2101; 6943; 59548; 70926; 78740; 94361; 17320 +Ptk2b Pyk2 P70600 rat PXN 360820 Q66H76 Pxn rat Y118 448604 AGEEEHVySFPNKQK Paxillin X 2541; 69363 +Ptk2b Pyk2 P70600 rat GJA1 24392 P08050 Gja1 rat Y267 465295 CGsPkyAyFNGCSSP X +Ptk2b Pyk2 P70600 rat JAK2 24514 Q62689 Jak2 rat Y1008 448408 LPQDKEyyKVKEPGE PK_Tyr_Ser-Thr X 3771; 3776; 8082; 66245 +Ptk2b Pyk2 P70600 rat JAK2 24514 Q62689 Jak2 rat Y1007 448407 VLPQDKEyyKVKEPG PK_Tyr_Ser-Thr X 3771; 3776; 4406; 66245 +Ptk2b Pyk2 P70600 rat Pyk2 50646 P70600 Ptk2b rat Y402 447955 CSIESDIyAEIPDET X 3291 +Ptk2b Pyk2 P70600 rat GJA1 24392 P08050 Gja1 rat Y247 447814 VKGRsDPyHATTGPL X X +CDKL2 CDKL2 Q92772 human BPY2-IP1 55201 Q66K74 MAP1S human S900 476391 DrAsRPLsARsEPsE X +Map2k4 MKK4 P47809 mouse JNK2 26420 Q9WTU6 Mapk9 mouse T183 447649 ACTNFMMtPyVVtRY Pkinase X X +Map2k4 MKK4 P47809 mouse JNK2 26420 Q9WTU6 Mapk9 mouse Y185 447652 TNFMMtPyVVtRYYR Pkinase X X +Map2k4 MKK4 P47809 mouse JNK1 26419 Q91Y86 Mapk8 mouse T183 447643 AGtsFMMtPyVVtRY Pkinase X X 5136; 4668; 4671; 9257; 9255; 9251; 4306; 5755; 16014; 58328 +Map2k4 MKK4 P47809 mouse JNK1 26419 Q91Y86 Mapk8 mouse Y185 447645 tsFMMtPyVVtRYYR Pkinase X X 5136; 4668; 4671; 9257; 9255; 9251; 4306; 5755; 16014; 58328 +CDK9 CDK9 P50750 human SIRT1 23411 Q96EB6 SIRT1 human S47 452899 DGPGLERsPGEPGGA X 2314 +CDK9 CDK9 P50750 human BAF53A 86 O96019 ACTL6A human S233 471130 kEAVREGsPANWkRk Actin X +CDK9 CDK9 P50750 human SMAD1 4086 Q15797 SMAD1 human S195 451174 PNSSYPNsPGSSSSt X +CDK9 CDK9 P50750 human SMAD1 4086 Q15797 SMAD1 human S187 451173 NSHPFPHsPNSSYPN X +CDK9 CDK9 P50750 human CDK9 1025 P50750 CDK9 human T186 450950 NSQPNRYtNRVVTLW Pkinase X 2549 +CDK9 CDK9 P50750 human OGFOD1 55239 Q8N543 OGFOD1 human S256 1874115106 FEPPIPRsPHIPQDH X +CDK9 CDK9 P50750 human p73 7161 O15350 TP73 human T86 449047 AASASPYtPEHAASV X +CDK9 CDK9 P50750 human SPT5 6829 O00267 SUPT5H human T784 458816 MyGsGsrtPMyGsQt X X +CDK9 CDK9 P50750 human H1F1 3024 Q02539 H1-1 human S183 15605000 KPKKVAKsPAKAKAV X X +CDK9 CDK9 P50750 human POLR2A 5430 P24928 POLR2A human T1525 1239966001 TPWNQGAtPAYGAWS X +CDK9 CDK9 P50750 human BORA 79866 Q6PGQ7 BORA human S325 4753166 sPYIDGCsPIKNWsP X X +CDK9 CDK9 P50750 human SPT5 6829 O00267 SUPT5H human T775 458815 tPMyGsQtPMyGsGs X X +CDK9 CDK9 P50750 human PPAR-gamma 5468 P37231 PPARG human S112 448062 AIkVEPAsPPYYSEK X +CDK9 CDK9 P50750 human CDK9 1025 P50750 CDK9 human S353 4271605 GsQItQQstNQsRNP X +CDK9 CDK9 P50750 human SPT5 6829 O00267 SUPT5H human T768 458814 MtStyGRtPMyGsQt X X +CDK9 CDK9 P50750 human SMAD1 4086 Q15797 SMAD1 human S206 451175 SSStYPHsPTSSDPG X X 9553; 5753 +CDK9 CDK9 P50750 human Rb 5925 P06400 RB1 human S795 447979 sPykFPssPLrIPGG Rb_C X 9301 +CDK9 CDK9 P50750 human MBP 618684 P02687 MBP cow S164 451833 GRDsRSGsPMARR__ Myelin_MBP X +CDK9 CDK9 P50750 human p53 7157 P04637 TP53 human S392 447535 FktEGPDsD______ X 9281 +CDK9 CDK9 P50750 human p53 7157 P04637 TP53 human S33 447531 LPENNVLsPLPsQAM X X 2526 +CDK9 CDK9 P50750 human MBP 618684 P02687 MBP cow T97 450929 KNIVtPRtPPPSQGK Myelin_MBP X +CDK9 CDK9 P50750 human CDK9 1025 P50750 CDK9 human T363 3681503 QsRNPAttNQtEFEr X +CDK9 CDK9 P50750 human SRC-2 10499 Q15596 NCOA2 human S487 4728845 GQPTSMLsPrHRMsP NCOA_u2 X +CDK9 CDK9 P50750 human SMAD1 4086 Q15797 SMAD1 human S214 451176 PTSSDPGsPFQMPAD X +CDK9 CDK9 P50750 human SMAD3 4088 P84022 SMAD3 human T179 451177 PQSNIPEtPPPGYLS X X +CDK9 CDK9 P50750 human SMAD3 4088 P84022 SMAD3 human S213 451180 NLsPNPMsPAHNNLD X +CDK9 CDK9 P50750 human H1E 3008 P10412 H1-4 human S187 458354 KPKKAPKsPAKAkAV X +CDK9 CDK9 P50750 human SPT5 6829 O00267 SUPT5H human T814 458820 PLHDGsRtPAQsGAW X X +CDK9 CDK9 P50750 human RCHY1 25898 Q96PM5 RCHY1 human T217 27971903 PsEYQNMtVDILCND zinc_ribbon_6 X X +CDK9 CDK9 P50750 human SMAD3 4088 P84022 SMAD3 human S208 451179 DAGsPNLsPNPMsPA X +CDK9 CDK9 P50750 human RCHY1 25898 Q96PM5 RCHY1 human S211 27971904 VAQTPMPsEYQNMtV zinc_ribbon_6 X X +CDK9 CDK9 P50750 human MDM2 4193 Q00987 MDM2 human S166 448130 SsRRRAIsEtEENsD X 3521 +CDK9 CDK9 P50750 human SPT5 6829 O00267 SUPT5H human T806 458819 tPHyGsQtPLHDGsR X X +CDK9 CDK9 P50750 human POLR2A 5430 P24928 POLR2A human S1616 450204 TPQSPSysPtsPsYS RNA_pol_Rpb1_R X X 4735; 13499; 13546; 31262 +CDK9 CDK9 P50750 human XRN2 22803 Q9H0D6 XRN2 human T439 3211959 FtPsGILtPHALGsR XRN_M X X +CDK9 CDK9 P50750 human CDK9 1025 P50750 CDK9 human T362 3681501 NQsRNPAttNQtEFE X +CDK9 CDK9 P50750 human SPT5 6829 O00267 SUPT5H human T799 458818 PLQDGsRtPHyGsQt X X +CDK9 CDK9 P50750 human SPT5 6829 O00267 SUPT5H human S782 4948434 tPMyGsGsrtPMyGs X +CDK9 CDK9 P50750 human SPT5 6829 O00267 SUPT5H human S773 15415344 GRtPMyGsQtPMyGs X +CDK9 CDK9 P50750 human POLR2A 5430 P24928 POLR2A human S1621 3439802 SysPtsPsYSPTSPS RNA_pol_Rpb1_R X 13780 +CDK9 CDK9 P50750 human SPT5 6829 O00267 SUPT5H human T791 458817 tPMyGsQtPLQDGsR X X +CDK9 CDK9 P50750 human MED1 5469 Q15648 MED1 human T1032 458308 SSSNRPFtPPTsTGG X X +CDK9 CDK9 P50750 human AR 367 P10275 AR human S83 448714 QQQQQETsPRQQQQQ Androgen_recep X +CDK9 CDK9 P50750 human POLR2A 5430 P24928 POLR2A human T1618 25042600 QSPSysPtsPsYSPT RNA_pol_Rpb1_R X 14934; 26319 +CDK9 CDK9 P50750 human SRC-2 10499 Q15596 NCOA2 human S493 468245 LsPrHRMsPGVAGsP NCOA_u2 X +CDK9 CDK9 P50750 human POLR2A 5430 P24928 POLR2A human T1540 1239966000 PSVGSGMtPGAAGFS X +CDK9 CDK9 P50750 human POLR2A 5430 P24928 POLR2A human S1619 447616 SPSysPtsPsYSPTS RNA_pol_Rpb1_R X X 4735; 13523; 13546; 67221 +CDK9 CDK9 P50750 human SPT5 6829 O00267 SUPT5H human S666 468817 VGGFAPMsPrISsPM X +CDK9 CDK9 P50750 human BAF53A 86 O96019 ACTL6A human S195 1876807200 LQQGIVksPLAGDFI Actin X +CDK9 CDK9 P50750 human BAF53A 86 O96019 ACTL6A human S86 18908932 RENMEAIsPLkNGMV Actin X +CDK9 CDK9 P50750 human Rb 5925 P06400 RB1 human S807 447980 PGGNIyIsPLksPyk Rb_C X 9308; 8974; 4277; 40283; 8957; 8516; 11917; 99274; 41359; 75864; 72443 +CDK9 CDK9 P50750 human CDK9 1025 P50750 CDK9 human S347 3681502 APPRRkGsQItQQst X +CDK9 CDK9 P50750 human MCEF 27125 Q9UHB7 AFF4 human S388 470820 KDDLKLsssEDsDGE AF-4 X +CDK9 CDK9 P50750 human SRC-2 10499 Q15596 NCOA2 human S499 4728850 MsPGVAGsPrIPPSQ NCOA_u2 X +CDK9 CDK9 P50750 human Rb 5925 P06400 RB1 human S811 448717 IyIsPLksPykIsEG Rb_C X 9308; 8974; 4277; 40283; 8957; 8516; 11917; 41359; 75864; 63276 +CDK9 CDK9 P50750 human p53 7157 P04637 TP53 human S315 447530 LPNNtsssPQPkkkP X 2528 +CDK9 CDK9 P50750 human SRC-2 10499 Q15596 NCOA2 human S469 4728825 NYALKMNsPsQSsPG NCOA_u2 X +CDK9 CDK9 P50750 human CDK9 1025 P50750 CDK9 human T354 26367600 sQItQQstNQsRNPA X +Cad CAD P08955 hamster CAD 101843763 P08955 Cad hamster T1037 2861417 QQCRVLGtSPEAIDS X +Taok2 TAO2 Q6ZQ29 mouse SEPT7 235072 O55131 Septin7 mouse T425 476328 EQQnssRtLEKNKKK X +MELK MELK Q14680 human CDC25B 994 P30305 CDC25B human S169 455885 VLRNItNsQAPDGRR M-inducer_phosp X X +MELK MELK Q14680 human MELK 9833 Q14680 MELK human T539 2861410 RGLDkVItVLtRsKR X +MELK MELK Q14680 human MELK 9833 Q14680 MELK human T387 25353601 DLSTGAAtPRTsQFT X +MELK MELK Q14680 human MELK 9833 Q14680 MELK human T494 2861408 TGtDkLMtGVIsPER X X +MELK MELK Q14680 human MELK 9833 Q14680 MELK human S431 2861402 ENVytPKsAVkNEEy X X +MELK MELK Q14680 human MELK 9833 Q14680 MELK human T398 2861401 sQFTkYWtEsNGVEs X X +MELK MELK Q14680 human MELK 9833 Q14680 MELK human T167 456039 NkDyHLQtCCGsLAY Pkinase X X +MELK MELK Q14680 human MELK 9833 Q14680 MELK human S171 2861400 HLQtCCGsLAYAAPE Pkinase X +MELK MELK Q14680 human CDC25B 994 P30305 CDC25B human S323 448409 QRLFRsPsMPCsVIR M-inducer_phosp X +MELK MELK Q14680 human MELK 9833 Q14680 MELK human S405 25353602 tEsNGVEsksLtPAL X +MELK MELK Q14680 human MELK 9833 Q14680 MELK human T409 15412181 GVEsksLtPALCRtP X +MELK MELK Q14680 human MELK 9833 Q14680 MELK human S356 2861407 DIKSNNWsLEDVTAs X X +MELK MELK Q14680 human MELK 9833 Q14680 MELK human Y438 459427 sAVkNEEyFMFPEPK X +MELK MELK Q14680 human MELK 9833 Q14680 MELK human S529 468187 KGAkVFGsLERGLDk X X +MELK MELK Q14680 human MELK 9833 Q14680 MELK human Y367 25353600 VTAsDKNyVAGLIDY X +MELK MELK Q14680 human EIF4B 1975 P23588 EIF4B human S406 470374 RPRERHPsWRsEEtQ X X 8151; 5399 +MELK MELK Q14680 human EZH2 2146 Q15910 EZH2 human S220 25291187 RPPRKFPsDKIFEAI PRC2_HTH_1 X X +MELK MELK Q14680 human ZNF622 52521 Q91VY9 Znf622 mouse T251 63052801 PLGAIPItDCLFCSH zf-C2H2_2 X X +MELK MELK Q14680 human MELK 9833 Q14680 MELK human S505 2861409 sPERRCRsVELDLNQ X X +MELK MELK Q14680 human MELK 9833 Q14680 MELK human S407 2861404 sNGVEsksLtPALCR X +MELK MELK Q14680 human MELK 9833 Q14680 MELK human S336 2861412 PVRLRLssFsCGQAs X +MELK MELK Q14680 human MELK 9833 Q14680 MELK human S343 2861403 sFsCGQAsAtPFtDI X X +MELK MELK Q14680 human MELK 9833 Q14680 MELK human S391 2861405 GAAtPRTsQFTkYWt X +MELK MELK Q14680 human EIF4B 1975 P23588 EIF4B human S422 451290 RERsRtGsEssQtGt X 3591 +MELK MELK Q14680 human MELK 9833 Q14680 MELK human Y163 2861413 kPKGNkDyHLQtCCG Pkinase X +MELK MELK Q14680 human MELK 9833 Q14680 MELK human S253 2861411 VDPKKRIsMkNLLNH Pkinase X +MELK MELK Q14680 human MELK 9833 Q14680 MELK human T56 2861406 sDLPRIktEIEALkN Pkinase X +MAP2K1 MEK1 Q02750 human MyoD 17927 P10085 Myod1 mouse Y156 18755302 ILRNAIRyIEGLQAL HLH X +MAP2K1 MEK1 Q02750 human ERK1 50689 P21708 Mapk3 rat Y205 447543 HTGFLtEyVAtRWYR Pkinase X 9106; 4370; 4374; 9101; 4375; 4376; 4377; 3510; 5726; 88569; 13214; 13148; 70235; 9488; 89967; 8544; 14196; 14227; 14095; 14474; 75165; 98168; 33370; 54240; 15892; 45899; 55088; 9524; 69217; 48735 +MAP2K1 MEK1 Q02750 human Ku70 2547 P12956 XRCC6 human S77 1875071706 VYISKIIssDRDLLA Ku_N X +MAP2K1 MEK1 Q02750 human NPAS4 225872 Q8BGD7 Npas4 mouse S580 1871095702 KLPPsPSsPGNGDCT X X +MAP2K1 MEK1 Q02750 human PPAR-gamma 19016 P37238 Pparg mouse S133 38507801 PHEEPSNsLMAIECR X +MAP2K1 MEK1 Q02750 human NPAS4 225872 Q8BGD7 Npas4 mouse T427 1869686800 LVCTPPYtPHQPGGC X X +MAP2K1 MEK1 Q02750 human TDP-43 23435 Q13148 TARDBP human T153 63083902 GFGFVRFtEyETQVk RRM_1 X +MAP2K1 MEK1 Q02750 human ERK2 26413 P63085 Mapk1 mouse Y185 447594 HtGFLtEyVAtRWYR Pkinase X X 9106; 4370; 4374; 9101; 4375; 4376; 4377; 3510; 5726; 88569; 13214; 13148; 70235; 9488; 89967; 8544; 14196; 14227; 14095; 14474; 75165; 98168; 33370; 54240; 15892; 45899; 55088; 9524; 69217; 48735 +MAP2K1 MEK1 Q02750 human ERK1 5595 P27361 MAPK3 human T207 3949243 FLtEyVAtRWyrAPE Pkinase X +MAP2K1 MEK1 Q02750 human MLXIP 22877 Q9HAP2 MLXIP human Y222 40556408 IEIVIREyHKWRTYF X +MAP2K1 MEK1 Q02750 human ERK1 26417 Q63844 Mapk3 mouse T203 447542 HDHtGFLtEyVAtRW Pkinase X 9106; 4370; 4374; 9101; 4375; 4376; 4377; 3510; 5726; 88569; 13214; 13148; 70235; 9488; 89967; 8544; 14196; 14227; 14095; 14474; 75165; 98168; 33370; 54240; 15892; 45899; 55088; 9524; 69217; 48735 +MAP2K1 MEK1 Q02750 human ERK2 26413 P63085 Mapk1 mouse T183 447593 HDHtGFLtEyVAtRW Pkinase X X 9106; 4370; 4374; 9101; 4375; 4376; 4377; 3510; 5726; 88569; 13214; 13148; 70235; 9488; 89967; 8544; 14196; 14227; 14095; 14474; 75165; 98168; 33370; 54240; 15892; 45899; 55088; 9524; 69217; 48735 +MAP2K1 MEK1 Q02750 human ERK2 116590 P63086 Mapk1 rat T183 447593 HDHtGFLtEyVAtRW Pkinase X 9106; 4370; 4374; 9101; 4375; 4376; 4377; 3510; 5726; 88569; 13214; 13148; 70235; 9488; 89967; 8544; 14196; 14227; 14095; 14474; 75165; 98168; 33370; 54240; 15892; 45899; 55088; 9524; 69217; 48735 +MAP2K1 MEK1 Q02750 human GSK3B 2932 P49841 GSK3B human Y216 448569 RGEPNVsyICsRyyR Pkinase X X +MAP2K1 MEK1 Q02750 human K8 3856 P05787 KRT8 human S74 448539 tVNQsLLsPLVLEVD Keratin_2_head X +MAP2K1 MEK1 Q02750 human RAF1 110157 Q99N57 Raf1 mouse S338 447742 RPRGQRDssyyWEIE X 9427 +MAP2K1 MEK1 Q02750 human TDP-43 23435 Q13148 TARDBP human Y155 464438 GFVRFtEyETQVkVM RRM_1 X +MAP2K1 MEK1 Q02750 human NPAS4 225872 Q8BGD7 Npas4 mouse T423 1871095704 LSKDLVCtPPYtPHQ X X +MAP2K1 MEK1 Q02750 human NPAS4 225872 Q8BGD7 Npas4 mouse S615 1871095701 GLLtPEAsPVKQSFF X X +MAP2K1 MEK1 Q02750 human ERK1 50689 P21708 Mapk3 rat T203 447542 HDHTGFLtEyVAtRW Pkinase X 9106; 4370; 4374; 9101; 4375; 4376; 4377; 3510; 5726; 88569; 13214; 13148; 70235; 9488; 89967; 8544; 14196; 14227; 14095; 14474; 75165; 98168; 33370; 54240; 15892; 45899; 55088; 9524; 69217; 48735 +MAP2K1 MEK1 Q02750 human ERK1 26417 Q63844 Mapk3 mouse Y205 447543 HtGFLtEyVAtRWyR Pkinase X 9106; 4370; 4374; 9101; 4375; 4376; 4377; 3510; 5726; 88569; 13214; 13148; 70235; 9488; 89967; 8544; 14196; 14227; 14095; 14474; 75165; 98168; 33370; 54240; 15892; 45899; 55088; 9524; 69217; 48735 +MAP2K1 MEK1 Q02750 human MACC1 346389 Q6ZN28 MACC1 human Y793 1874020222 KPAYDFLyTWSAHYG X +MAP2K1 MEK1 Q02750 human MACC1 346389 Q6ZN28 MACC1 human Y673 1874020218 VLADVLGySHLSLED X +MAP2K1 MEK1 Q02750 human ERK2 5594 P28482 MAPK1 human T185 447593 HDHtGFLtEyVAtRW Pkinase X X 9106; 4370; 4374; 9101; 4375; 4376; 4377; 3510; 5726; 88569; 13214; 13148; 70235; 9488; 89967; 8544; 14196; 14227; 14095; 14474; 75165; 98168; 33370; 54240; 15892; 45899; 55088; 9524; 69217; 48735 +MAP2K1 MEK1 Q02750 human ERK1 5595 P27361 MAPK3 human Y210 459504 EyVAtRWyrAPEIML Pkinase X +MAP2K1 MEK1 Q02750 human NPAS4 225872 Q8BGD7 Npas4 mouse T611 1871095703 LVPEGLLtPEAsPVK X X +MAP2K1 MEK1 Q02750 human ERK2 116590 P63086 Mapk1 rat Y185 447594 HtGFLtEyVAtRWYR Pkinase X 9106; 4370; 4374; 9101; 4375; 4376; 4377; 3510; 5726; 88569; 13214; 13148; 70235; 9488; 89967; 8544; 14196; 14227; 14095; 14474; 75165; 98168; 33370; 54240; 15892; 45899; 55088; 9524; 69217; 48735 +MAP2K1 MEK1 Q02750 human MACC1 346389 Q6ZN28 MACC1 human Y695 1874020220 KESEKVSyVIKKLKE X +MAP2K1 MEK1 Q02750 human ERK1 5595 P27361 MAPK3 human T202 447542 HDHtGFLtEyVAtRW Pkinase X X 9106; 4370; 4374; 9101; 4375; 4376; 4377; 3510; 5726; 88569; 13214; 13148; 70235; 9488; 89967; 8544; 14196; 14227; 14095; 14474; 75165; 98168; 33370; 54240; 15892; 45899; 55088; 9524; 69217; 48735 +MAP2K1 MEK1 Q02750 human TAL1 6886 P17542 TAL1 human S122 450663 DGRMVQLsPPALAAP X +MAP2K1 MEK1 Q02750 human ARRB2 25388 P29067 Arrb2 rat T383 455373 EFDTNYAtDDDIVFE X X +MAP2K1 MEK1 Q02750 human ERK2 5594 P28482 MAPK1 human Y187 447594 HtGFLtEyVAtRWyr Pkinase X X 9106; 4370; 4374; 9101; 4375; 4376; 4377; 3510; 5726; 88569; 13214; 13148; 70235; 9488; 89967; 8544; 14196; 14227; 14095; 14474; 75165; 98168; 33370; 54240; 15892; 45899; 55088; 9524; 69217; 48735 +MAP2K1 MEK1 Q02750 human HSF1 3297 Q00613 HSF1 human S326 455484 ssVDtLLsPTALIDs Vert_HS_TF X X +MAP2K1 MEK1 Q02750 human Ku70 2547 P12956 XRCC6 human S78 1875071708 YISKIIssDRDLLAV Ku_N X +MAP2K1 MEK1 Q02750 human RAF1 5894 P04049 RAF1 human S338 447742 RPRGQRDssyyWEIE X 9427 +MAP2K1 MEK1 Q02750 human ERK1 5595 P27361 MAPK3 human Y204 447543 HtGFLtEyVAtRWyr Pkinase X X 9106; 4370; 4374; 9101; 4375; 4376; 4377; 3510; 5726; 88569; 13214; 13148; 70235; 9488; 89967; 8544; 14196; 14227; 14095; 14474; 75165; 98168; 33370; 54240; 15892; 45899; 55088; 9524; 69217; 48735 +MAP2K1 MEK1 Q02750 human NPAS4 225872 Q8BGD7 Npas4 mouse S577 1871095700 LYEKLPPsPSsPGNG X X +MAP2K1 MEK1 Q02750 human PR 5241 P06401 PGR human S294 447987 APMAPGRsPLATTVM Prog_receptor X 13736 +Map3k8 Cot Q07174 mouse PLCB3 18797 P51432 Plcb3 mouse S537 448450 TSLEPQKsLGEEsLS X 2481; 29021 +Pak1 PAK1 P35465 rat Merlin 25744 Q63648 Nf2 rat S514 448282 DTDMKRLsMEIEKEK ERM_C X 9163; 13281 +Pak1 PAK1 P35465 rat PAK1 29431 P35465 Pak1 rat S21 448174 APPMRNTsTMIGAGS X +Pak1 PAK1 P35465 rat SHOT1 292139 A0MZ67 Shtn1 rat S101 4761847 NKTLKRIsMLYMAKL X +Pak1 PAK1 P35465 rat SYN1 24949 P09951 Syn1 rat S9 448378 NYLRRRLsDSNFMAN Synapsin_N X 2311; 67605 +Pak1 PAK1 P35465 rat SYN1 24949 P09951 Syn1 rat S603 450236 AGPIRQAsQAGPGPR X 88246 +Pak1 PAK1 P35465 rat PAK1 29431 P35465 Pak1 rat T422 448177 PEQSKRstMVGTPYW Pkinase X X +Pak1 PAK1 P35465 rat PAK1 29431 P35465 Pak1 rat S198 448172 PRPEHTKsVYTRsVI X +Pak1 PAK1 P35465 rat SYN1 281510 P17599 SYN1 cow S551 451574 PATRPPAsPsPQRQA X +Pak1 PAK1 P35465 rat SHOT1 292139 A0MZ67 Shtn1 rat S249 485709 QNKLKRQsHLLLQSS X +Pak1 PAK1 P35465 rat PAK1 29431 P35465 Pak1 rat S203 448173 TKsVYTRsVIEPLPV X +Pak1 PAK1 P35465 rat MEK1 170851 Q01986 Map2k1 rat S298 448284 RtPGRPLsSYGMDSR Pkinase X 9128; 98195 +Pak1 PAK1 P35465 rat SYN1 281510 P17599 SYN1 cow S605 450236 AGPTRQAsQAGPMPR X +Pak1 PAK1 P35465 rat SYN1 281510 P17599 SYN1 cow S9 448378 NYLRRRLsDSNFMAN Synapsin_N X +Pak1 PAK1 P35465 rat PRKD1 85421 Q9WTQ1 Prkd1 rat S203 449896 GVRRRRLsNVsLTGL X +Pak1 PAK1 P35465 rat PAK1 29431 P35465 Pak1 rat S144 448170 SNSQKYMsFTDKsAE X +Pak1 PAK1 P35465 rat HACE1 57531 Q8IYU2 HACE1 human S385 10940679 LMKNKRDsTEITsIL X +GRK4 GRK4 P32298 human GRK4 2868 P32298 GRK4 human S10 41590803 LENIVANsLLLkARQ X +GRK4 GRK4 P32298 human GRK4 2868 P32298 GRK4 human S430 41590801 MLLtKNPsKRLGCRG Pkinase X +GRK4 GRK4 P32298 human BKR2 624 P30411 BDKRB2 human S366 447663 EPIQMENsMGTLRTs X +GRK4 GRK4 P32298 human BKR2 624 P30411 BDKRB2 human S375 447665 GTLRTsIsVERQIHk X +GRK4 GRK4 P32298 human DRD1 24316 P18901 Drd1 rat T428 458339 sVILDYDtDVsLEKI X +GRK4 GRK4 P32298 human GRK4 2868 P32298 GRK4 human S419 41590806 KFSEDAKsICRMLLt Pkinase X +GRK4 GRK4 P32298 human GRK4 2868 P32298 GRK4 human S139 41590800 GLKEENPsKKAFEEC RGS X +GRK4 GRK4 P32298 human GRK4 2868 P32298 GRK4 human T426 41590804 sICRMLLtKNPsKRL Pkinase X +GRK4 GRK4 P32298 human GRK4 2868 P32298 GRK4 human S249 41590802 VQsRFVVsLAYAYEt Pkinase X +GRK4 GRK4 P32298 human GRK4 2868 P32298 GRK4 human S244 41590807 RILEKVQsRFVVsLA Pkinase X +GRK4 GRK4 P32298 human BKR2 624 P30411 BDKRB2 human S373 447664 sMGTLRTsIsVERQI X +GRK4 GRK4 P32298 human GRK4 2868 P32298 GRK4 human S485 23111438 VLDIEQFsVVKGIYL X +GRK4 GRK4 P32298 human GRK4 2868 P32298 GRK4 human T256 41590805 sLAYAYEtKDALCLV Pkinase X +GRK4 GRK4 P32298 human DRD1 24316 P18901 Drd1 rat S431 458340 LDYDtDVsLEKIQPV X +Myo3b MYO3B Q1EG27 mouse MYO3B 329421 Q1EG27 Myo3b mouse T178 36841906 sTRLRRNtSVGTPFW Pkinase X +Myo3b MYO3B Q1EG27 mouse MYO3B 329421 Q1EG27 Myo3b mouse S171 36841905 GVSAQLTsTRLRRNt Pkinase X +Myo3b MYO3B Q1EG27 mouse MYO3B 329421 Q1EG27 Myo3b mouse T918 36841908 TTNMKRQtMASYFRY Myosin_head X +Myo3b MYO3B Q1EG27 mouse MYO3B 329421 Q1EG27 Myo3b mouse S887 36841907 KITASSRsLPPHFSA Myosin_head X +Myo3b MYO3B Q1EG27 mouse MYO3B 329421 Q1EG27 Myo3b mouse T1246 36841909 YYNQLNGtLEYQGSQ X +SIK2 QIK Q9H0K1 human STX16 228960 Q8BVI5 Stx16 mouse T7 4754210 _MATRRLtDAFLLLR X +SIK2 QIK Q9H0K1 human PIK3R1 5295 P27986 PIK3R1 human S154 7445250 stLYRtQsSSNLAEL RhoGAP X +SIK2 QIK Q9H0K1 human CDK5R1 8851 Q15078 CDK5R1 human S91 12607404 ENLKKSLsCANLSTF CDK5_activator X X +SIK2 QIK Q9H0K1 human LRP6 4040 O75581 LRP6 human S1490 456289 AILNPPPsPAtERsH X X 2568 +SIK2 QIK Q9H0K1 human TORC3 70461 Q91X84 Crtc3 mouse S162 7101661 SALNRTNsDSALHTS TORC_M X +SIK2 QIK Q9H0K1 human TORC3 70461 Q91X84 Crtc3 mouse S370 1210886 SLRLFsLsNPsLSTT X +SIK2 QIK Q9H0K1 human PIK3R1 5295 P27986 PIK3R1 human S541 57829901 RISEIIDsRRRLEED PI3K_P85_iSH2 X X +SIK2 QIK Q9H0K1 human smMLCK 4638 Q15746 MYLK human S343 468783 PVLQKTSsSITLQAA 23ISL X X +SIK2 QIK Q9H0K1 human TORC3 70461 Q91X84 Crtc3 mouse S62 3203139 LtQyHGGsLPNVSQL TORC_N X +SIK2 QIK Q9H0K1 human LRP6 4040 O75581 LRP6 human S1420 460717 YVVHGPAsVPLGYVP X X +SIK2 QIK Q9H0K1 human IRS1 25467 P35570 Irs1 rat S789 447557 QHLRLSSsSGRLRYT X 2389 +SIK2 QIK Q9H0K1 human QIK 23235 Q9H0K1 SIK2 human S90 25120404 YQVMETKsMLYLVTE Pkinase X +SIK2 QIK Q9H0K1 human TORC2 74343 Q3U182 Crtc2 mouse S171 454622 sALNRtSsDsALHTs TORC_M X X +SIK2 QIK Q9H0K1 human CEP250 11190 Q9BV73 CEP250 human S2392 4728455 AGLHHsLsHsLLAVA X X +SIK2 QIK Q9H0K1 human TORC3 70461 Q91X84 Crtc3 mouse S329 468980 SGLQSsRsNPsIQAT X +SIK2 QIK Q9H0K1 human QIK 23235 Q9H0K1 SIK2 human S343 2150903 RLKSHRssFPVEQRL X +SIK2 QIK Q9H0K1 human HDAC5 10014 Q9UQL6 HDAC5 human S259 447995 FPLRkTAsEPNLKVR X 3443 +SIK2 QIK Q9H0K1 human QIK 23235 Q9H0K1 SIK2 human S358 487501 DGRQRRPstIAEQTV X +SIK2 QIK Q9H0K1 human CEP250 11190 Q9BV73 CEP250 human S2394 4728460 LHHsLsHsLLAVAQA X X +Mapk10 JNK3 Q61831 mouse DLK 26404 Q60700 Map3k12 mouse S533 27447446 RNVPQKLsPHSKRPD X X +Mapk10 JNK3 Q61831 mouse Bcl-2 596 P10415 BCL2 human T74 448632 ARtsPLQtPAAPGAA X +Mapk10 JNK3 Q61831 mouse JIP3 iso2 30957 Q9ESN9-2 Mapk8ip3 mouse T255 458343 SVPSAAVtPLNESLQ X +Mapk10 JNK3 Q61831 mouse DLK 26404 Q60700 Map3k12 mouse T43 4727854 CtPEKDLtPTQCVLR X X +Mapk10 JNK3 Q61831 mouse Bcl-2 596 P10415 BCL2 human S87 448396 AAAGPALsPVPPVVH X +Mapk10 JNK3 Q61831 mouse BIM 12125 O54918 Bcl2l11 mouse S65 449330 GPLAPPAsPGPFATR X 4581; 4585 +Mapk10 JNK3 Q61831 mouse JIP3 iso2 30957 Q9ESN9-2 Mapk8ip3 mouse T244 458342 TTGTKSNtPTSSVPS X +Mapk10 JNK3 Q61831 mouse Bcl-2 596 P10415 BCL2 human S70 448395 RDPVARtsPLQtPAA X 2834; 2827 +Mapk10 JNK3 Q61831 mouse Jun 16476 P05627 Jun mouse S63 447686 kNsDLLtsPDVGLLK Jun X 5464; 9261; 2361; 97721; 91952 +Mapk10 JNK3 Q61831 mouse MCL1 17210 P97287 Mcl1 mouse S102 1172400 SAAAAIVsPEEELDG X +Mapk10 JNK3 Q61831 mouse MCL1 17210 P97287 Mcl1 mouse T144 455375 ADGsLPStPPPPEEE X 4579 +Mapk10 JNK3 Q61831 mouse KIF5C 16574 P28738 Kif5c mouse S176 54436200 CTERFVSsPEEVMDV Kinesin X +Mapk10 JNK3 Q61831 mouse Bcl-2 596 P10415 BCL2 human T56 448655 FSSQPGHtPHPAASR X 2875 +Mapk10 JNK3 Q61831 mouse JIP3 iso2 30957 Q9ESN9-2 Mapk8ip3 mouse T234 458341 GQSSAAAtPSTTGTK X +MAP2K3 MKK3 P46734 human P38D 26415 Q9Z1B7 Mapk13 mouse Y182 454935 TDTEMtGyVVTRWYR Pkinase X 9211; 9215; 4551; 9216; 4552; 4631; 4511; 4092; 9219; 24678; 8632; 6908; 41768; 51255; 14594; 14598; 62979 +MAP2K3 MKK3 P46734 human P38A 26416 P47811 Mapk14 mouse T180 447970 RHtDDEMtGyVAtRW Pkinase X 9211; 9215; 4551; 9216; 4552; 4631; 4511; 4092; 9219; 24678; 8632; 6908; 41768; 51255; 14594; 14598; 62979 +MAP2K3 MKK3 P46734 human P38A 81649 P70618 Mapk14 rat T180 447970 RHTDDEMtGyVATRW Pkinase X 9211; 9215; 4551; 9216; 4552; 4631; 4511; 4092; 9219; 24678; 8632; 6908; 41768; 51255; 14594; 14598; 62979 +MAP2K3 MKK3 P46734 human P38A 81649 P70618 Mapk14 rat Y182 447971 TDDEMtGyVATRWYR Pkinase X 9211; 9215; 4551; 9216; 4552; 4631; 4511; 4092; 9219; 24678; 8632; 6908; 41768; 51255; 14594; 14598; 62979 +MAP2K3 MKK3 P46734 human MKK3 5606 P46734 MAP2K3 human S218 448276 IsGyLVDsVAKtMDA Pkinase X 9231; 9236; 12280 +MAP2K3 MKK3 P46734 human P38D 5603 O15264 MAPK13 human T180 4787496 RHADAEMtGyVVtRW Pkinase X 9211; 9215; 4551; 9216; 4552; 4631; 4511; 4092; 9219; 24678; 8632; 6908; 41768; 51255; 14594; 14598; 62979 +MAP2K3 MKK3 P46734 human P38A 1432 Q16539 MAPK14 human T180 447970 RHtDDEMtGyVAtRW Pkinase X X 9211; 9215; 4551; 9216; 4552; 4631; 4511; 4092; 9219; 24678; 8632; 6908; 41768; 51255; 14594; 14598; 62979 +MAP2K3 MKK3 P46734 human P38A 26416 P47811 Mapk14 mouse Y182 447971 tDDEMtGyVAtRWYR Pkinase X 9211; 9215; 4551; 9216; 4552; 4631; 4511; 4092; 9219; 24678; 8632; 6908; 41768; 51255; 14594; 14598; 62979 +MAP2K3 MKK3 P46734 human P38D 26415 Q9Z1B7 Mapk13 mouse T180 4787496 RHTDTEMtGyVVTRW Pkinase X 9211; 9215; 4551; 9216; 4552; 4631; 4511; 4092; 9219; 24678; 8632; 6908; 41768; 51255; 14594; 14598; 62979 +MAP2K3 MKK3 P46734 human P38D 5603 O15264 MAPK13 human Y182 454935 ADAEMtGyVVtRWYR Pkinase X 9211; 9215; 4551; 9216; 4552; 4631; 4511; 4092; 9219; 24678; 8632; 6908; 41768; 51255; 14594; 14598; 62979 +MAP2K3 MKK3 P46734 human MKK3 5606 P46734 MAP2K3 human T222 448277 LVDsVAKtMDAGCKP Pkinase X +MAP2K3 MKK3 P46734 human P38A 1432 Q16539 MAPK14 human Y182 447971 tDDEMtGyVAtRWYR Pkinase X X 9211; 9215; 4551; 9216; 4552; 4631; 4511; 4092; 9219; 24678; 8632; 6908; 41768; 51255; 14594; 14598; 62979 + ERK1 no information NRF2 4780 Q16236 NFE2L2 human S408 10292700 GDMVQPLsPSQGQST X + ERK1 no information NRF2 4780 Q16236 NFE2L2 human S577 10292702 DEDGkPysPSEYSLQ X + ERK1 no information NRF2 4780 Q16236 NFE2L2 human S215 10292704 VETTMVPsPEAKLTE X +CDK6 CDK6 Q00534 human Rb 5925 P06400 RB1 human S780 447978 strPPtLsPIPHIPr Rb_C X X 9307; 3590; 8180 +CDK6 CDK6 Q00534 human TFEB 7942 P19484 TFEB human S467 4785142 KASsRRssFsMEEGD DUF3371 X +CDK6 CDK6 Q00534 human Rb-like 2 5934 Q08999 RBL2 human T401 449723 SKALRIStPLtGVRY X +CDK6 CDK6 Q00534 human TFEB 7942 P19484 TFEB human T331 3181634 RVHGLPttsPsGMNM DUF3371 X +CDK6 CDK6 Q00534 human FOXM1 2305 Q08050 FOXM1 human T510 22648003 EDSSQsPtPRPKKSy X +CDK6 CDK6 Q00534 human AML1 iso8 861 Q01196-8 RUNX1 human S276 454399 DTRQIQPsPPWSYDQ X +CDK6 CDK6 Q00534 human AML1 iso8 861 Q01196-8 RUNX1 human S48 452744 TPPSTALsPGKMSEA X +CDK6 CDK6 Q00534 human FOXM1 2305 Q08050 FOXM1 human T611 451437 ETLPISstPSkSVLP X +CDK6 CDK6 Q00534 human TSC2 7249 P49815 TSC2 human S1452 3191272 LPSssPRsPsGLrPr X +CDK6 CDK6 Q00534 human FOXM1 2305 Q08050 FOXM1 human S508 22648001 sWEDSSQsPtPRPKK X +CDK6 CDK6 Q00534 human EGLN2 112398 Q96KS0 EGLN2 human S130 31088285 EDGGDAPsPsKRPWA X +CDK6 CDK6 Q00534 human AML1 iso8 861 Q01196-8 RUNX1 human T300 454403 sPSVHPAtPIsPGRA X +CDK6 CDK6 Q00534 human PKM iso2 5315 P14618-2 PKM human S37 476070 MCRLDIDsPPITARN X +CDK6 CDK6 Q00534 human FOXM1 2305 Q08050 FOXM1 human S522 8146040 KSySGLRsPtRCVSE X +CDK6 CDK6 Q00534 human PTPN2 19255 Q06180 Ptpn2 mouse S304 451134 LsPICDHsQNRVMVE X X +CDK6 CDK6 Q00534 human Rb 5925 P06400 RB1 human T826 447984 LPtPtkMtPRsRILV Rb_C X +CDK6 CDK6 Q00534 human Rb 19645 P13405 Rb1 mouse S804 448717 IyIsPLksPyKIsEG Rb_C X 9308; 8974; 4277; 40283; 8957; 8516; 11917; 41359; 75864 +CDK6 CDK6 Q00534 human AML1 iso8 861 Q01196-8 RUNX1 human S424 1308915 SMVGGERsPPRILPP RunxI X +CDK6 CDK6 Q00534 human Rb-like 2 5934 Q08999 RBL2 human S672 448254 tLyDRySsPPAsTtR X +CDK6 CDK6 Q00534 human Rb 5925 P06400 RB1 human S795 447979 sPykFPssPLrIPGG Rb_C X 9301 +CDK6 CDK6 Q00534 human CELF1 10658 Q92879 CELF1 human S302 3347301 TSSGSsPsSSSSNSV X +CDK6 CDK6 Q00534 human Rb 5925 P06400 RB1 human T252 449821 PINGsPRtPRRGQNR X X +CDK6 CDK6 Q00534 human PFKFB3 5209 Q16875 PFKFB3 human S467 468406 NsVtPLAsPEPtKKP X +CDK6 CDK6 Q00534 human Rb 5925 P06400 RB1 human S788 450022 PIPHIPrsPykFPss Rb_C X +CDK6 CDK6 Q00534 human FOXM1 2305 Q08050 FOXM1 human T627 3194576 tPEsWRLtPPAKVGG X +CDK6 CDK6 Q00534 human Rb 5925 P06400 RB1 human S249 447975 AVIPINGsPRtPRRG X X +CDK6 CDK6 Q00534 human PFKFB3 5209 Q16875 PFKFB3 human T463 468407 LMRRNsVtPLAsPEP X +CDK6 CDK6 Q00534 human Rb-like 2 5934 Q08999 RBL2 human S1035 449738 NMDAPPLsPyPFVRt X +CDK6 CDK6 Q00534 human NPM1 4869 P06748 NPM1 human T199 448515 VkKsIrDtPAkNAQK X 3541; 75984 +CDK6 CDK6 Q00534 human Rb 5925 P06400 RB1 human S612 447977 MyLsPVRsPKKKGsT X +CDK6 CDK6 Q00534 human FOXM1 2305 Q08050 FOXM1 human S704 449265 IDVPKPGsPEPQVSG X +CDK6 CDK6 Q00534 human TFEB 7942 P19484 TFEB human S142 3181628 AGNsAPNsPMAMLHI MITF_TFEB_C_3_N X X +CDK6 CDK6 Q00534 human AML1 iso8 861 Q01196-8 RUNX1 human S303 454401 VHPAtPIsPGRASGM X +CDK6 CDK6 Q00534 human p27Kip1 1027 P46527 CDKN1B human T187 447875 NAGsVEQtPKKPGLR X +CDK6 CDK6 Q00534 human PKM 5315 P14618 PKM human S37 476070 MCRLDIDsPPItARN X +CDK6 CDK6 Q00534 human PTPN2 19255 Q06180 Ptpn2 mouse S298 3181136 ELsKEDLsPICDHsQ X X +CDK6 CDK6 Q00534 human p21Cip1 1026 P38936 CDKN1A human S130 455618 sGEQAEGsPGGPGDs X +CDK6 CDK6 Q00534 human FOXM1 2305 Q08050 FOXM1 human S489 22648002 PPLEEWPsPAPSFkE X +CDK6 CDK6 Q00534 human TFEB 7942 P19484 TFEB human S114 3181613 HIsPAQGsPkPPPAA MITF_TFEB_C_3_N X +CDK6 CDK6 Q00534 human Rb 19645 P13405 Rb1 mouse S773 447978 STRPPtLsPIPHIPR Rb_C X 9307; 3590; 8180 +CDK6 CDK6 Q00534 human PTP1B 19246 P35821 Ptpn1 mouse S50 447811 RNRyRDVsPFDHSRI Y_phosphatase X X +CDK6 CDK6 Q00534 human PTP1B 19246 P35821 Ptpn1 mouse S205 36133122 VRESGSLsLEHGPIV Y_phosphatase X X +CDK6 CDK6 Q00534 human TFE3 7030 P19532 TFE3 human S246 56653430 PTGSAPNsPMALLTI MITF_TFEB_C_3_N X X +CDK6 CDK6 Q00534 human FLNA 2316 P21333 FLNA human S2152 451357 tRRRRAPsVANVGsH Filamin X 4761 +CDK6 CDK6 Q00534 human HuR 1994 Q15717 ELAVL1 human S202 3197192 LLsQLyHsPArrFGG X X +CDK6 CDK6 Q00534 human Rb 5925 P06400 RB1 human T821 447983 kIsEGLPtPtkMtPR Rb_C X 31433 +CDK6 CDK6 Q00534 human RPRM 56475 Q9NS64 RPRM human S98 15722493 LVKDRRPsKEVEAVV X X +CDK6 CDK6 Q00534 human p27Kip1 1027 P46527 CDKN1B human S10 447874 NVRVSNGsPsLErMD X +CDK6 CDK6 Q00534 human PTPN2 19255 Q06180 Ptpn2 mouse S52 23136003 RNRYRDVsPYDHSRV Y_phosphatase X X +CDK6 CDK6 Q00534 human FOXM1 2305 Q08050 FOXM1 human T600 478080 EVGGPFKtPIkETLP X 14655 +CDK6 CDK6 Q00534 human p53 7157 P04637 TP53 human R249 394791401 CMGGMNRrPILTIIT P53 X +CDK6 CDK6 Q00534 human Rb 5925 P06400 RB1 human S807 447980 PGGNIyIsPLksPyk Rb_C X X 9308; 8974; 4277; 40283; 8957; 8516; 11917; 99274; 41359; 75864; 72443 +CDK6 CDK6 Q00534 human FLNA 2316 P21333 FLNA human S1459 452266 kCsGPGLsPGMVRAN Filamin X +CDK6 CDK6 Q00534 human FOXM1 2305 Q08050 FOXM1 human T620 3194573 SkSVLPRtPEsWRLt X +CDK6 CDK6 Q00534 human AML1 iso8 861 Q01196-8 RUNX1 human S293 454400 QYLGSIAsPSVHPAt X +CDK6 CDK6 Q00534 human TSC2 7249 P49815 TSC2 human S1217 1868502602 MSLENPLsPFSSDIN X +CDK6 CDK6 Q00534 human Rb 5925 P06400 RB1 human S811 448717 IyIsPLksPykIsEG Rb_C X X 9308; 8974; 4277; 40283; 8957; 8516; 11917; 41359; 75864; 63276 +CDK6 CDK6 Q00534 human FOXM1 2305 Q08050 FOXM1 human S451 7320841 LLFGEGFsPLLPVQT X +CDK6 CDK6 Q00534 human PTPN2 19255 Q06180 Ptpn2 mouse T261 10997733 YRMGLIQtPDQLRFS Y_phosphatase X X +CDK6 CDK6 Q00534 human Rb 19645 P13405 Rb1 mouse S800 447980 PGGNIyIsPLksPyK Rb_C X 9308; 8974; 4277; 40283; 8957; 8516; 11917; 41359; 75864; 72443 +CDK8 CDK8 P49336 human STAT1 6772 P42224 STAT1 human S727 447753 TDNLLPMsPEEFDEV STAT1_TAZ2bind X X 9177; 8826; 62390 +CDK8 CDK8 P49336 human OSBPL3 iso3 71720 D3Z194 Osbpl3 mouse S264 6209027 IQGGAFEsPKKEKRP X +CDK8 CDK8 P49336 human SMAD1 4086 Q15797 SMAD1 human S195 451174 PNSSYPNsPGSSSSt X +CDK8 CDK8 P49336 human SMAD1 4086 Q15797 SMAD1 human S187 451173 NSHPFPHsPNSSYPN X +CDK8 CDK8 P49336 human E2F1 1869 Q01094 E2F1 human S375 3193946 PVDEDRLsPLVAADS X X +CDK8 CDK8 P49336 human H3 8350 P68431 H3C1 human S10 455676 tkQtArkstGGkAPr Histone X X 9701; 9711; 9606; 3465; 3642; 3377; 3475; 3458; 5764; 47398; 8481; 8552; 53348; 29237; 66065; 43185; 64522; 52725 +CDK8 CDK8 P49336 human SMAD1 4086 Q15797 SMAD1 human S206 451175 SSStYPHsPTSSDPG X X 9553; 5753 +CDK8 CDK8 P49336 human CCNH 902 P51946 CCNH human S304 12521707 yEDDDyVsKKsKHEE X X +CDK8 CDK8 P49336 human SMAD1 4086 Q15797 SMAD1 human S214 451176 PTSSDPGsPFQMPAD X +CDK8 CDK8 P49336 human SMAD3 4088 P84022 SMAD3 human T179 451177 PQSNIPEtPPPGYLS X X +CDK8 CDK8 P49336 human SMAD3 4088 P84022 SMAD3 human S213 451180 NLsPNPMsPAHNNLD X +CDK8 CDK8 P49336 human STAT3 20848 P42227 Stat3 mouse S727 448191 NtIDLPMsPRTLDSL X 9134; 9136; 34911; 94994; 49081; 58978; 87544; 71958; 50804 +CDK8 CDK8 P49336 human STAT5A 20850 P42230 Stat5a mouse S725 448749 TYMDQAPsPVVCPQP X +CDK8 CDK8 P49336 human Notch 1 4851 P46531 NOTCH1 human S2513 35483201 EHPFLtPsPEsPDQW X X +CDK8 CDK8 P49336 human Notch 1 4851 P46531 NOTCH1 human T2511 483083 VPEHPFLtPsPEsPD X X +CDK8 CDK8 P49336 human SMAD3 4088 P84022 SMAD3 human S208 451179 DAGsPNLsPNPMsPA X +CDK8 CDK8 P49336 human CCNH 902 P51946 CCNH human S5 456230 ___MYHNsSQkRHWT X X +CDK8 CDK8 P49336 human Notch 1 4851 P46531 NOTCH1 human S2516 35483202 FLtPsPEsPDQWsss X +CDK8 CDK8 P49336 human STAT1 20846 P42225 Stat1 mouse S727 447753 tDNLLPMsPEEFDEM STAT1_TAZ2bind X 9177; 8826; 62390 +Prkcb PKCB P68403 rat TUBA1B 10376 P68363 TUBA1B human T253 31889716 GALNVDLtEFQtNLV X X +Prkcb PKCB P68403 rat PLCB3 29322 Q99JE6 Plcb3 rat S1105 448448 LDRKRNNsISEAKTR PLC-beta_C X 2484 +Prkcb PKCB P68403 rat PKCB 25023 P68403 Prkcb rat T642 447897 tRQPVELtPTDKLFI Pkinase_C X +Prkcb PKCB P68403 rat RKIP 29542 P31044 Pebp1 rat S153 448755 RGkFkVEsFRKKYHL PBP X +Prkcb PKCB P68403 rat ATF-2 1386 P15336 ATF2 human S367 451442 ERNRAAAsRCRQKRk bZIP_1 X +Prkcb PKCB P68403 rat PKCB 25023 P68403 Prkcb rat T314 447894 RAkIGQGtkAPEEkT X +Prkcb PKCB P68403 rat PKCB 25023 P68403 Prkcb rat S661 448672 QNEFAGFsYTNPEFV Pkinase_C X 9371 +Prkcb PKCB P68403 rat Kv3.1 25327 P25122 Kcnc1 rat S503 464642 LEINRADsKLNGEVA X +Prkcb PKCB P68403 rat PKCB 25023 P68403 Prkcb rat T324 447895 PEEkTANtISkFDNN X +Prkcb PKCB P68403 rat ATF-2 1386 P15336 ATF2 human S340 451441 tPQtQSTsGRRRRAA X +Prkcb PKCB P68403 rat PKCB 25023 P68403 Prkcb rat T17 447893 PsEGEEstVRFARKG X +Prkcb PKCB P68403 rat PKCB 25023 P68403 Prkcb rat T635 1869073012 sNFDKEFtRQPVELt Pkinase_C X +Prkcb PKCB P68403 rat NOX1 114243 Q9WV87 Nox1 rat T429 36552501 RAHNKLKtQKIYFYW NAD_binding_6 X X +Prkcb PKCB P68403 rat CD5 921 P06127 CD5 human T434 450129 MsFHRNHtAtVRsHA X +Prkcb PKCB P68403 rat VDR 7421 P11473 VDR human S51 451285 CKGFFRRsMKRKALF zf-C4 X +Prkcb PKCB P68403 rat PKCB 25023 P68403 Prkcb rat S16 447892 PPsEGEEstVRFARK X +Prkcb PKCB P68403 rat G-gamma 12 14701 Q9DAS9 Gng12 mouse S2 447876 ______MssktAstN X +Prkcb PKCB P68403 rat TH 25085 P04177 Th rat S31 448544 KQAEAVtsPRFIGRR TOH_N X 3370; 13041 +Prkcb PKCB P68403 rat GLUT1 24778 P11167 Slc2a1 rat S226 10827359 NEENRAKsVLKKLRG Sugar_tr X +Prkcb PKCB P68403 rat CD5 921 P06127 CD5 human T436 450130 FHRNHtAtVRsHAEN X +PTK2 FAK Q05397 human CDCP1 64866 Q9H5V8 CDCP1 human Y734 451434 KDNDsHVyAVIEDTM X 9050 +PTK2 FAK Q05397 human PXN 395832 P49024 PXN chicken Y118 448604 AsEEEHVysFPNKQK Paxillin X 69363 +PTK2 FAK Q05397 human PIK3R2 5296 O00459 PIK3R2 human Y464 449572 sREyDQLyEEytRTS PI3K_P85_iSH2 X X 17366; 62098; 81913 +PTK2 FAK Q05397 human CTNNB1 1499 P35222 CTNNB1 human Y142 449044 AVVNLINyQDDAELA X +PTK2 FAK Q05397 human ITGB7 3695 P26010 ITGB7 human Y753 469601 YRLSVEIyDRREySR Integrin_b_cyt X +PTK2 FAK Q05397 human NANOG 79923 Q9H9S0 NANOG human Y35 25240301 ICGPEENyPSLQMSS X X +PTK2 FAK Q05397 human beclin 1 8678 Q14457 BECN1 human Y233 477225 EAQyQREysEFkRQQ APG6_N X +PTK2 FAK Q05397 human ACTN1 87 P12814 ACTN1 human Y12 450200 DsQQtNDyMQPEEDW X X +PTK2 FAK Q05397 human PXN 5829 P49023 PXN human Y118 448604 VGEEEHVysFPNkQk Paxillin X 2541; 69363 +PTK2 FAK Q05397 human Cortactin 13043 Q60598 Cttn mouse Y421 447702 RPPssPIyEDAAPFK X 4569 +PTK2 FAK Q05397 human P130Cas 9564 P56945 BCAR1 human Y165 448722 PSPATDLyQVPPGPG X 4015 +PTK2 FAK Q05397 human Akt1 207 P31749 AKT1 human S473 447855 RPHFPQFsysAsGtA Pkinase_C X 9271; 3787; 4060; 4051; 5102; 4058; 2336; 2337; 4075; 4070; 5012; 4071; 92982; 5315; 9563; 9018; 12694; 52240; 11962; 15116; 88106; 26580; 68035; 31957; 23430; 20235 +PTK2 FAK Q05397 human PXN 360820 Q66H76 Pxn rat Y31 448785 FLSEEPPySYPTGNH X +PTK2 FAK Q05397 human LAT iso2 27040 O43561-2 LAT human Y171 448004 SMESIDDyVNVPESG LAT X X +PTK2 FAK Q05397 human FAK 5747 Q05397 PTK2 human Y577 447890 yMEDstyyKAsKGKL PK_Tyr_Ser-Thr X 3281 +PTK2 FAK Q05397 human GIT1 28964 Q9Y2X7 GIT1 human Y321 15702200 FLPVNPEySATRNQG X +PTK2 FAK Q05397 human PMCA4 iso6 493 P23634-6 ATP2B4 human Y1176 449557 LDGEVTPyANTNNNA X +PTK2 FAK Q05397 human FAK 5747 Q05397 PTK2 human Y407 447888 IIDEEDtytMPSTRD X +PTK2 FAK Q05397 human TRIO 7204 O75962 TRIO human Y2796 11263902 KDNFDsFySEVAELG Pkinase X +PTK2 FAK Q05397 human P130Cas 9564 P56945 BCAR1 human Y410 448720 GVVDsGVyAVPPPAE X 4011 +PTK2 FAK Q05397 human GRB7 2886 Q14451 GRB7 human Y338 7965101 AAFRLFKyGVQLyKN PH X +PTK2 FAK Q05397 human FAK 14083 P34152 Ptk2 mouse Y397 447887 sVsEtDDyAEIIDEE X 3283; 8556 +PTK2 FAK Q05397 human ITGB7 3695 P26010 ITGB7 human Y758 469602 EIyDRREySRFEkEQ Integrin_b_cyt X +PTK2 FAK Q05397 human HDAC5 10014 Q9UQL6 HDAC5 human Y642 1869973801 PLQPLQVyQAPLSLA X X +PTK2 FAK Q05397 human Claudin-11 5010 O75508 CLDN11 human Y191 478785 AFGENRFyyTAGsss X +PTK2 FAK Q05397 human FAK 5747 Q05397 PTK2 human Y397 447887 sVsEtDDyAEIIDEE X X 3283; 8556 +PTK2 FAK Q05397 human endophilin A2 6455 Q99961 SH3GL1 human Y315 450745 QPSCKALyDFEPEND SH3_1 X X +PTK2 FAK Q05397 human RAC1 5879 P63000 RAC1 human Y64 475227 DTAGQEDyDRLRPLs Ras X +PTK2 FAK Q05397 human TAK1 26409 Q62073 Map3k7 mouse S412 455196 NGQPRRRsIQDLtVT X 9339 +PTK2 FAK Q05397 human Claudin-11 5010 O75508 CLDN11 human Y192 478786 FGENRFyyTAGsssP X +PTK2 FAK Q05397 human Ret 5979 P07949 RET human Y905 447627 DVyEEDsyVKRsQGR PK_Tyr_Ser-Thr X X 3221 +PTK2 FAK Q05397 human Cofilin-1 12631 P18760 Cfl1 mouse S3 448444 _____MAsGVAVsDG X 3313; 3311 +PTK2 FAK Q05397 human Cortactin 13043 Q60598 Cttn mouse Y466 447703 TyTSEPVyETTEAPG X +PTK2 FAK Q05397 human FAK 25614 O35346 Ptk2 rat Y397 447887 SVSETDDyAEIIDEE X 3283; 8556 +PTK2 FAK Q05397 human FAK 5747 Q05397 PTK2 human Y576 447889 RyMEDstyyKAsKGK PK_Tyr_Ser-Thr X X 3281 +PTK2 FAK Q05397 human GRB7 2886 Q14451 GRB7 human Y188 7965100 FRKNFAKyELFKssP X +PTK2 FAK Q05397 human NANOG 79923 Q9H9S0 NANOG human Y174 25240300 QKASAPTyPSLYSSY X X +PTK2 FAK Q05397 human TGFBR1 21812 Q64729 Tgfbr1 mouse Y182 7791190 TTLKDLIyDMttsGs TGF_beta_GS X +Map3k14 Nik Q9WUL6 mouse CREB 12912 Q01147 Creb1 mouse S119 448228 EILsRRPsyRkILND pKID X 9187; 9196; 9198; 4095; 14228; 14001; 39561; 80120; 44864; 54960; 95995 +Sik1 SIK Q9R1U5 rat SIK 59329 Q9R1U5 Sik1 rat S186 2560900 PLStWCGsPPYAAPE Pkinase X +ADCK5 ADCK5 Q3MIX3 human SOX9 6662 P48436 SOX9 human S181 456981 YQPRRRKsVKNGQAE X +EPHB3 EphB3 P54753 human EphB3 2049 P54753 EPHB3 human Y614 448275 VyIDPFtyEDPNEAV EphA2_TM X +TYRO3 Tyro3 Q06418 human MLKL 197259 Q8NB16 MLKL human Y376 1868624704 DRVkstAyLSPQELE PK_Tyr_Ser-Thr X X +TYRO3 Tyro3 Q06418 human Akt1 207 P31749 AKT1 human T308 447856 kDGAtMKtFCGtPEy Pkinase X 5106; 2965; 9275; 4056; 5056; 13842; 13038; 43506; 48646; 86758; 80722; 77440; 80556 +MAST3 MAST3 O60307 human ARPP-19 iso2 10776 P56211-2 ARPP19 human S46 465742 KGQKYFDsGDYNMAK Endosulfine X X +Pikfyve PIKFYVE Q9Z1T6 mouse Akt1 207 P31749 AKT1 human S473 447855 RPHFPQFsysAsGtA Pkinase_C X 9271; 3787; 4060; 4051; 5102; 4058; 2336; 2337; 4075; 4070; 5012; 4071; 92982; 5315; 9563; 9018; 12694; 52240; 11962; 15116; 88106; 26580; 68035; 31957; 23430; 20235 +Eif2ak2 PKR Q03963 mouse PKR 19106 Q03963 Eif2ak2 mouse T414 448089 SRtRRTGtLQYMSPE Pkinase X +Eif2ak2 PKR Q03963 mouse IRS1 16367 P35569 Irs1 mouse S307 447558 tEsITAtsPAsMVGG X X 2381 +Eif2ak2 PKR Q03963 mouse eIF2-alpha 13665 Q6ZWX6 Eif2s1 mouse S52 447635 MILLSELsRrrIRSI S1 X X 3597; 9721; 3398; 5199; 53085; 95797 +Epha3 EphA3 P29319 mouse EphA3 13837 P29319 Epha3 mouse Y596 449912 KLPGLRTyVDPHTyE EphA2_TM X +Epha3 EphA3 P29319 mouse EphA3 13837 P29319 Epha3 mouse Y602 449913 TyVDPHTyEDPTQAV EphA2_TM X +Epha3 EphA3 P29319 mouse EphA3 13837 P29319 Epha3 mouse Y779 448910 EDDPEAAyttRGGKI PK_Tyr_Ser-Thr X 8793; 8862 +PCK1 PCK1 P35558 human INSIG2 51141 Q9Y5U4 INSIG2 human S151 1868515112 LWWTFDRsRSGFGLG INSIG X X +PCK1 PCK1 P35558 human INSIG1 3638 O15503 INSIG1 human S207 1868515111 LWWTFDRsRsGLGLG INSIG X X +Camk2a CAMK2A P11798 mouse phosducin 25343 P20942 Pdc rat S36 10431702 WRKFKLEsEDGDSIP Phosducin X +Camk2a CAMK2A P11798 mouse RYR2 6262 Q92736 RYR2 human S2814 458801 IsQTSQVsVDAAHGY X +Camk2a CAMK2A P11798 mouse GluR1 14799 P23818 Gria1 mouse S849 448565 FCLIPQQsINEAIRt X X 75574 +Camk2a CAMK2A P11798 mouse DRP1 74006 Q8K1M6 Dnm1l mouse S622 454690 PIPIMPAsPQKGHAV X 3455; 4494; 63940 +Camk2a CAMK2A P11798 mouse SCN5A 20271 Q9JJV9 Scn5a mouse S571 27281507 PWPLRRPsTQGQPGF Na_trans_cytopl X +Camk2a CAMK2A P11798 mouse GABBR1 54393 Q9WV18 Gabbr1 mouse S867 15167000 ITRGEWQsEAQDtMK X +Camk2a CAMK2A P11798 mouse DAT 6531 Q01959 SLC6A3 human S13 451138 CsVGLMssVVAPAKE X +Camk2a CAMK2A P11798 mouse phosducin 25343 P20942 Pdc rat S106 10431701 QDMHQKLsFGPRYGF Phosducin X +Camk2a CAMK2A P11798 mouse CAMK2A 12322 P11798 Camk2a mouse T305 448802 kLkGAILttMLAtRN X +Camk2a CAMK2A P11798 mouse KIF17 16559 Q99PW8 Kif17 mouse S1029 1720900 SKAKRKKsKNSFGGE X X +Camk2a CAMK2A P11798 mouse HOMER1 26556 Q9Z2Y3 Homer1 mouse S117 51633300 ARLAKEKsQEKMELT X +Camk2a CAMK2A P11798 mouse Vimentin 22352 P20152 Vim mouse S83 451816 GVRLLQDsVdFsLAD Filament_head X 3878; 12569 +Camk2a CAMK2A P11798 mouse ADCY3 104111 Q8VHH7 Adcy3 mouse S1077 452063 NVASRMEsTGVMGNI Guanylate_cyc X +Camk2a CAMK2A P11798 mouse FosB 14282 P13346 Fosb mouse T149 35530404 PRRPREEtLTPEEEE X +Camk2a CAMK2A P11798 mouse NFL 18039 P08551 Nefl mouse S58 457405 LsVRRsyssSSGsLM Filament_head X +Camk2a CAMK2A P11798 mouse CREB iso1 81646 P15337-1 Creb1 rat S133 448228 EILsRRPsYRkILND pKID X X 9187; 9196; 9198; 4095; 14228; 14001; 39561; 80120; 44864; 54960; 95995 +Camk2a CAMK2A P11798 mouse MYBPC3 17868 O70468 Mybpc3 mouse S410 30324206 GsKYIFEsVGAkRTL I-set X +Camk2a CAMK2A P11798 mouse MYBPC3 17868 O70468 Mybpc3 mouse S47 4699355 VRWQRDGsDItANDK I-set X +Camk2a CAMK2A P11798 mouse MYO5A 17918 Q99104 Myo5a mouse S1650 480053 GLRKRtssIADEGty X +Camk2a CAMK2A P11798 mouse MECP2 29386 Q00566 Mecp2 rat S421 470075 EKMPRAGsLESDGCP X +Camk2a CAMK2A P11798 mouse PPP1R3A 100009140 Q00756 RG1 rabbit S48 449320 PQPSRRGsESSEEVY X X +Camk2a CAMK2A P11798 mouse ANO1 101772 Q8BHY3 Ano1 mouse S673 288031701 YLKLRRQsPSDREEY Anoctamin X +Camk2a CAMK2A P11798 mouse PLB 18821 P61014 Pln mouse T17 448115 SAIRRAstIEMPQQA Phospholamban X X 8496 +Camk2a CAMK2A P11798 mouse DAT 6531 Q01959 SLC6A3 human S4 454428 ____MsKskCsVGLM X +Camk2a CAMK2A P11798 mouse SYN1 iso1 20964 O88935-1 Syn1 mouse S605 450236 AGPTRQAsQAGPGPR X +Camk2a CAMK2A P11798 mouse PLB 18821 P61014 Pln mouse S16 448114 RSAIRRAstIEMPQQ Phospholamban X 8496 +Camk2a CAMK2A P11798 mouse CREB iso1 81646 P15337-1 Creb1 rat S142 448547 RkILNDLssDAPGVP pKID X X +Camk2a CAMK2A P11798 mouse DAT 6531 Q01959 SLC6A3 human S12 451137 kCsVGLMssVVAPAK X +Camk2a CAMK2A P11798 mouse DAT 6531 Q01959 SLC6A3 human S2 451135 ______MsKskCsVG X +Camk2a CAMK2A P11798 mouse SERCA2 29693 P11507 Atp2a2 rat S38 448740 KLKERWGsNELPAEE Cation_ATPase_N X +Camk2a CAMK2A P11798 mouse MYBPC3 17868 O70468 Mybpc3 mouse S210 23252009 QHLQLHDsyDRASKV I-set X +Camk2a CAMK2A P11798 mouse MYBPC3 17868 O70468 Mybpc3 mouse S25 30324201 SAEVTAGsAAVFEAE I-set X +Camk2a CAMK2A P11798 mouse CAMK2A 12322 P11798 Camk2a mouse T286 447797 sCMHRQEtVDCLkkF X X 12716 +Camk2a CAMK2A P11798 mouse MYBPC3 17868 O70468 Mybpc3 mouse S282 471080 AGAGRRtsDsHEDAG X +Camk2a CAMK2A P11798 mouse ITGB1 16412 P09055 Itgb1 mouse T788 448600 PIyksAVttVVNPky Integrin_b_cyt X +Camk2a CAMK2A P11798 mouse gp130 16195 Q00560 Il6st mouse S780 448180 QVFSRsEstQPLLDs X X +Camk2a CAMK2A P11798 mouse PTPRA 19262 P18052 Ptpra mouse S204 447612 PLLARsPstNRKYPP X +Camk2a CAMK2A P11798 mouse MCU 215999 Q3UMR5 Mcu mouse S91 27259017 VISVRLPsRRERCQF X +Camk2a CAMK2A P11798 mouse MYBPC3 17868 O70468 Mybpc3 mouse T50 30324202 QRDGsDItANDKYGL I-set X +Camk2a CAMK2A P11798 mouse HOMER2 26557 Q9QWW1 Homer2 mouse S216 51633301 EQWKRQFsICRDEND X +Camk2a CAMK2A P11798 mouse MYBPC3 17868 O70468 Mybpc3 mouse T380 30324205 KGHkIRLtVELADPD I-set X +Camk2a CAMK2A P11798 mouse MYBPC3 17868 O70468 Mybpc3 mouse T290 4699397 DsHEDAGtPDFSsLL X +Camk2a CAMK2A P11798 mouse STX3 iso2 20908 Q64704-2 Stx3 mouse T14 31960301 QLKAKQLtQDDDTDE X +Camk2a CAMK2A P11798 mouse phosducin 25343 P20942 Pdc rat S73 451205 ERMSRKMsIQEYELI Phosducin X +Camk2a CAMK2A P11798 mouse PEA-15 18611 Q62048 Pea15 mouse S116 450281 KDIIRQPsEEEIIKL X X +Camk2a CAMK2A P11798 mouse CREM 12916 P27699 Crem mouse S133 448412 EILSRRPsYRKILNE pKID X 4095; 14228; 14001 +Camk2a CAMK2A P11798 mouse phosducin 25343 P20942 Pdc rat S6 10431700 __MEEAAsQSLEEDF Phosducin X +Camk2a CAMK2A P11798 mouse GluR1 14799 P23818 Gria1 mouse T858 3362100 NEAIRtstLPRNsGA X +Camk2a CAMK2A P11798 mouse FosB 14282 P13346 Fosb mouse S27 465535 SAESQYLsSVDSFGS X +Camk2a CAMK2A P11798 mouse phosducin 25343 P20942 Pdc rat S54 454888 KEILRQMsSPQSRDD Phosducin X +Camk2a CAMK2A P11798 mouse ITGB1 16412 P09055 Itgb1 mouse T789 447709 IyksAVttVVNPkyE Integrin_b_cyt X +Camk2a CAMK2A P11798 mouse MYBPC3 17868 O70468 Mybpc3 mouse S302 471081 sLLKKRDsFRRDskL X X +Camk2a CAMK2A P11798 mouse DAT 6531 Q01959 SLC6A3 human S7 451136 _MsKskCsVGLMssV X +Camk2a CAMK2A P11798 mouse PTPRA 19262 P18052 Ptpra mouse S180 447611 QAGsHSNsFRLSNGR X +Camk2a CAMK2A P11798 mouse RYR2 20191 E9Q401 Ryr2 mouse S2813 458801 IsQtsQVsIDAAHGY X X +Camk2a CAMK2A P11798 mouse MYBPC3 17868 O70468 Mybpc3 mouse S307 2846505 RDsFRRDskLEAPAE X +Camk2a CAMK2A P11798 mouse STMN1 16765 P54227 Stmn1 mouse S16 448554 KELEKRAsGQAFELI Stathmin X 3353 +Camk2a CAMK2A P11798 mouse MYBPC3 17868 O70468 Mybpc3 mouse S105 17660717 APPEkAEsEVAPGAP X +Camk2a CAMK2A P11798 mouse CACNA1C 12288 Q01815 Cacna1c mouse S1545 467228 VACKRLVsMNMPLNS GPHH X +Camk2a CAMK2A P11798 mouse CACNA1C 12288 Q01815 Cacna1c mouse S1487 460572 DYLTRDWsILGPHHL Ion_trans X +Camk2a CAMK2A P11798 mouse MYH9 25745 Q62812 Myh9 rat T1940 452194 RRIVRKGtGDCsDEE X +Camk2a CAMK2A P11798 mouse NMDAR2B 14812 Q01097 Grin2b mouse S1303 450171 NKLRRQHsyDtFVDL NMDAR2_C X 20274; 71335 +Camk2a CAMK2A P11798 mouse NSDDR 747 Q9Y4D2 DAGLA human S782 27807805 APLATMEsLSDTESL X +Camk2a CAMK2A P11798 mouse MYBPC3 17868 O70468 Mybpc3 mouse S273 471079 RsAFRRtsLAGAGRR X +Camk2a CAMK2A P11798 mouse CAMK2A 12322 P11798 Camk2a mouse T306 449596 LkGAILttMLAtRNF X +Camk2a CAMK2A P11798 mouse NSDDR 747 Q9Y4D2 DAGLA human S808 27807806 RSIRGsPsLHAVLER X +Camk2a CAMK2A P11798 mouse FAK 14083 P34152 Ptk2 mouse S843 447963 DVRLsRGsIDREDGS X +RPS6KA1 p90RSK Q15418 human TERF2IP 54386 Q9NYB0 TERF2IP human S205 471278 GDAPVsPssQkLKRK X X +RPS6KA1 p90RSK Q15418 human AS160 9882 O60343 TBC1D4 human S318 455925 EFRsRCssVtGVQRR PID X 8619 +RPS6KA1 p90RSK Q15418 human NHE1 6548 P19634 SLC9A1 human S703 448347 MsRARIGsDPLAyEP X X +RPS6KA1 p90RSK Q15418 human KIBRA 23286 Q8IX03 WWC1 human S947 453630 CRLNRsDsDSSTLSK X X +RPS6KA1 p90RSK Q15418 human NDRG2 57447 Q9UN36 NDRG2 human S350 454251 RsRsRtLsQssEsGt X +RPS6KA1 p90RSK Q15418 human VASP 7408 P50552 VASP human T278 448381 LARRRKAtQVGEktP X X +RPS6KA1 p90RSK Q15418 human p90RSK 6195 Q15418 RPS6KA1 human K335 1881518211 KLYRREIkPPFKPAV X +RPS6KA1 p90RSK Q15418 human CDC25B 994 P30305 CDC25B human T355 3189697 NkRRRsVtPPEEQQE M-inducer_phosp X X +RPS6KA1 p90RSK Q15418 human p90RSK 81771 Q63531 Rps6ka1 rat S380 447990 HQLFRGFsFVATGLM Pkinase_C X 9341; 9335; 13575; 11989; 12032; 75266; 93317; 13397; 13588 +RPS6KA1 p90RSK Q15418 human REPS1 85021 Q96D71 REPS1 human S709 478670 PVRRRLksEDELRPE X X 12005 +RPS6KA1 p90RSK Q15418 human CDC25C 995 P30307 CDC25C human S247 30280700 kVKKkYFsGQGkLRK M-inducer_phosp X +RPS6KA1 p90RSK Q15418 human RIOK2 55781 Q9BVS4 RIOK2 human S483 7446950 QYRTRtLsItssGsA X X +RPS6KA1 p90RSK Q15418 human Nur77 15370 P12813 Nr4a1 mouse S354 447942 GRRGRLPsKPKQPPD X 5095 +RPS6KA1 p90RSK Q15418 human Raptor 57521 Q8N122 RPTOR human S721 4206802 tPrLrsVssyGNIRA X X +RPS6KA1 p90RSK Q15418 human SENP2 75826 Q91ZX6 Senp2 mouse T35 4769095 KRRRssstLFsTAVD X +RPS6KA1 p90RSK Q15418 human EEF2K 29904 O00418 EEF2K human S366 447827 sPQVRtLsGSRPPLL X X 3691 +RPS6KA1 p90RSK Q15418 human Mad1 4084 Q05195 MXD1 human S145 2807903 IERIRMDsIGSTVSS X X +RPS6KA1 p90RSK Q15418 human YB-1 4904 P67809 YBX1 human S102 455636 NPRKyLrsVGDGEtV CSD X X 2900 +RPS6KA1 p90RSK Q15418 human p90RSK 6195 Q15418 RPS6KA1 human S380 447990 HQLFRGFsFVAtGLM Pkinase_C X 9341; 9335; 13575; 11989; 12032; 75266; 93317; 13397; 13588 +RPS6KA1 p90RSK Q15418 human PDCD4 27250 Q53EL6 PDCD4 human S457 458382 RGRKRFVsEGDGGRL X X +RPS6KA1 p90RSK Q15418 human SOS1 6654 Q07889 SOS1 human S1134 483244 PHGPRsAsVssISLT X +RPS6KA1 p90RSK Q15418 human L-plastin 3936 P13796 LCP1 human S5 450852 ___MARGsVsDEEMM X X +RPS6KA1 p90RSK Q15418 human GAB2 14389 Q9Z1S8 Gab2 mouse S620 15410336 PsPHRKPstSsVtsD X +RPS6KA1 p90RSK Q15418 human SOS1 6654 Q07889 SOS1 human S1161 9413177 PPRRRPEsAPAEssP X +RPS6KA1 p90RSK Q15418 human Kv4.3 65195 Q62897 Kcnd3 rat S535 3681504 YPSTRSPsLSSHSGL DUF3399 X X +RPS6KA1 p90RSK Q15418 human BAD 12015 Q61337 Bad mouse S112 447860 ETRsRHssyPAGtEE Bcl-2_BAD X X 9291; 5284; 9296; 5193; 11865; 94223 +RPS6KA1 p90RSK Q15418 human p90RSK 81771 Q63531 Rps6ka1 rat S221 447988 DHEKKAYsFCGTVEY Pkinase X +RPS6KA1 p90RSK Q15418 human DAPK1 1612 P53355 DAPK1 human S289 457379 QALSRKAsAVNMEkF X +RPS6KA1 p90RSK Q15418 human METTL1 4234 Q9UBP6 METTL1 human S27 3627513 YYRQrAHsNPMADHT X X +RPS6KA1 p90RSK Q15418 human TSC2 24855 P49816 Tsc2 rat T1466 448546 GLRPRGYtISDSAPS X 3617; 3611 +RPS6KA1 p90RSK Q15418 human OSTF1 26578 Q92882 OSTF1 human S202 456078 TDAVRtLsNAEDyLD X X +RPS6KA1 p90RSK Q15418 human p90RSK 6195 Q15418 RPS6KA1 human K110 1881518209 VRDRVRTkMERDILA X +RPS6KA1 p90RSK Q15418 human CDC25A 993 P30304 CDC25A human S295 25286643 TKrRKsMsGASPkES M-inducer_phosp X X +RPS6KA1 p90RSK Q15418 human AS160 9882 O60343 TBC1D4 human S570 455923 AKRsLtssLENIFsr X +RPS6KA1 p90RSK Q15418 human EIF4B 75705 Q8BGD9 Eif4b mouse S422 451290 RERsRtGsEssQtGA X 3591 +RPS6KA1 p90RSK Q15418 human EphA2 1969 P29317 EPHA2 human S897 1244153 RVsIRLPstsGsEGV X X 16662; 6347 +RPS6KA1 p90RSK Q15418 human EIF4B 1975 P23588 EIF4B human S425 456897 sRtGsEssQtGtstt X +RPS6KA1 p90RSK Q15418 human ITGB4 3691 P16144 ITGB4 human S1364 451655 PSGsQRPsVSDDTGC X +RPS6KA1 p90RSK Q15418 human Fos 2353 P01100 FOS human S362 448481 AAAHRKGssSNEPSS X +RPS6KA1 p90RSK Q15418 human KIBRA 23286 Q8IX03 WWC1 human T929 3205626 stIIRsKtFsPGPQS X X +RPS6KA1 p90RSK Q15418 human IkB-alpha 4792 P25963 NFKBIA human S32 448203 LLDDRHDsGLDsMkD X 5210; 2859; 9246; 5209 +RPS6KA1 p90RSK Q15418 human MITF iso8 17342 Q08874-8 Mitf mouse S409 450265 KTSSRRSsMSAEETE DUF3371 X +RPS6KA1 p90RSK Q15418 human APAF 317 O14727 APAF1 human S268 23003805 LLTTRDksVTDsVMG NB-ARC X X +RPS6KA1 p90RSK Q15418 human CDC25B 994 P30305 CDC25B human S353 452008 VQNkRRRsVtPPEEQ M-inducer_phosp X X +RPS6KA1 p90RSK Q15418 human BAD 12015 Q61337 Bad mouse S155 447863 GRELRRMsDEFEGsF Bcl-2_BAD X 9297 +RPS6KA1 p90RSK Q15418 human UBR5 51366 O95071 UBR5 human S2483 480595 ENRKRHGssRsVVDM X X +RPS6KA1 p90RSK Q15418 human ERK5 23939 Q9WVS8 Mapk7 mouse S496 455518 SRLRDGPsAPLEAPE X +RPS6KA1 p90RSK Q15418 human ERK5 5598 Q13164 MAPK7 human S496 455518 SRLRDGPsAPLEAPE X +RPS6KA1 p90RSK Q15418 human BAD 572 Q92934 BAD human S75 447860 EIRsRHssyPAGtED Bcl-2_BAD X X 9291; 5284; 9296; 5193; 11865; 94223 +RPS6KA1 p90RSK Q15418 human p90RSK 81771 Q63531 Rps6ka1 rat S732 447991 RRVRKLPsTTL____ X +RPS6KA1 p90RSK Q15418 human DLC1 58834 Q63744 Dlc1 rat S330 458383 VTRTRSLsTCNKRVG X +RPS6KA1 p90RSK Q15418 human GAB2 14389 Q9Z1S8 Gab2 mouse S160 448382 LLRERKSsAPSHSsQ X 3884 +RPS6KA1 p90RSK Q15418 human p90RSK 6195 Q15418 RPS6KA1 human K421 1881518210 FSDGYVVkETIGVGS X +RPS6KA1 p90RSK Q15418 human Raptor 57521 Q8N122 RPTOR human S719 3205932 PCtPrLrsVssyGNI X X +RPS6KA1 p90RSK Q15418 human CREB 1385 P16220 CREB1 human S119 448228 EILsRRPsyRkILND pKID X X 9187; 9196; 9198; 4095; 14228; 14001; 39561; 80120; 44864; 54960; 95995 +RPS6KA1 p90RSK Q15418 human Kv4.3 65195 Q62897 Kcnd3 rat S569 455338 LPATRLRsMQELSTI X X +RPS6KA1 p90RSK Q15418 human CdGAP 57514 Q2M1Z3 ARHGAP31 human S1106 4694057 KGKNRPSsLNLDPAI X +RPS6KA1 p90RSK Q15418 human GSK3B 2932 P49841 GSK3B human S9 449111 SGRPRttsFAEsCkP X X 9336; 9331; 9327; 9323; 9322; 9325; 5558; 8566; 79774; 8466; 25462; 14026; 14332; 14310; 14630 +RPS6KA1 p90RSK Q15418 human NDRG2 57447 Q9UN36 NDRG2 human S332 451010 LsRsRtAsLtsAAsV X +RPS6KA1 p90RSK Q15418 human RANBP3 8498 Q9H6Z4 RANBP3 human S126 460735 VKRERtssLtQFPPs X X 9380 +RPS6KA1 p90RSK Q15418 human AS160 9882 O60343 TBC1D4 human S751 455924 EGRKRtsstCsNEsL X +RPS6KA1 p90RSK Q15418 human MAGI1 14924 Q6RHR9 Magi1 mouse S733 3896422 QPLERKDsQNssQHs MAGI_u5 X X +RPS6KA1 p90RSK Q15418 human capicua 23152 Q96RK0 CIC human S301 478739 EtRERsMsEtGtAAA X X +RPS6KA1 p90RSK Q15418 human DEPTOR 64798 Q8TB45 DEPTOR human S287 4723848 sMssCGssGyFsssP X X +RPS6KA1 p90RSK Q15418 human UBR5 51366 O95071 UBR5 human T637 3952394 PYKRRRstPAPKEEE X +RPS6KA1 p90RSK Q15418 human AS160 9882 O60343 TBC1D4 human S341 455922 QPRRRHAsAPsHVQP PID X +RPS6KA1 p90RSK Q15418 human TSC2 7249 P49815 TSC2 human S1798 454016 GQRKRLIssVEDFTE X +RPS6KA1 p90RSK Q15418 human TSC2 24855 P49816 Tsc2 rat S939 448501 KFRARSTsLNERPKS X 3615 +RPS6KA1 p90RSK Q15418 human SENP2 75826 Q91ZX6 Senp2 mouse T368 40499300 TEDLFEFtEDMEKEI X +RPS6KA1 p90RSK Q15418 human ER-alpha 2099 P03372 ESR1 human S167 448102 GGRERLAsTNDkGSM Oest_recep X X 64508; 42101 +RPS6KA1 p90RSK Q15418 human CARHSP1 23589 Q9Y2V2 CARHSP1 human S52 453062 tRRtrtFsAtVRAsQ X +RPS6KA1 p90RSK Q15418 human NHERF 9368 O14745 NHERF1 human T156 3864004 ELRPRLCtMKKGPsG PDZ X X +RPS6KA1 p90RSK Q15418 human K17 16667 Q9QWL7 Krt17 mouse S44 464291 AGsCRLGsASGLGSA X +RPS6KA1 p90RSK Q15418 human S6 6194 P62753 RPS6 human S236 448093 AKRRRLssLRAstsK X X 5006; 4856; 4857; 4858; 4851; 4803; 2211; 3945; 3985; 5316; 4854; 8520; 48319; 40643; 9865; 38573; 14733; 27036; 34411; 62016; 62788; 81736; 97935; 99457; 15448 +RPS6KA1 p90RSK Q15418 human Chk1 1111 O14757 CHEK1 human S280 447831 AKRPRVtsGGVsEsP X X 2347 +RPS6KA1 p90RSK Q15418 human MITF iso9 4286 O75030-9 MITF human S409 450265 KTSsRRSsMSMEETE DUF3371 X X +RPS6KA1 p90RSK Q15418 human NFkB-p65 5970 Q04206 RELA human S276 447798 sMQLRRPsDRELsEP RHD_dimer X +RPS6KA1 p90RSK Q15418 human DEPTOR 64798 Q8TB45 DEPTOR human S286 21697912 ssMssCGssGyFsss X X +RPS6KA1 p90RSK Q15418 human FLNA 2316 P21333 FLNA human S2152 451357 tRRRRAPsVANVGsH Filamin X X 4761 +RPS6KA1 p90RSK Q15418 human AS160 9882 O60343 TBC1D4 human T642 455921 QFRRRAHtFsHPPss X 4288; 8881 +RPS6KA1 p90RSK Q15418 human CCT2 10576 P78371 CCT2 human S260 472352 GsRVRVDstAkVAEI Cpn60_TCP1 X X +RPS6KA1 p90RSK Q15418 human AS160 9882 O60343 TBC1D4 human T568 486326 NKAKRsLtssLENIF X +RPS6KA1 p90RSK Q15418 human APAF 317 O14727 APAF1 human S357 23003807 FKRIRKSsSYDYEAL NB-ARC X X +RPS6KA1 p90RSK Q15418 human AS160 9882 O60343 TBC1D4 human S588 455920 RMRGRLGsVDsFERs X 8730 +RPS6KA1 p90RSK Q15418 human UBR5 51366 O95071 UBR5 human S1227 21214703 DCKLKRTsPTAYCDC X +RPS6KA1 p90RSK Q15418 human SENP2 75826 Q91ZX6 Senp2 mouse S38 25753045 RssstLFsTAVDtDE X +RPS6KA1 p90RSK Q15418 human AS160 9882 O60343 TBC1D4 human S666 486327 GRAQGVRsPLLRQSS X +RPS6KA1 p90RSK Q15418 human YB-1 22608 P62960 Ybx1 mouse S100 455636 NPRKyLRsVGDGEtV CSD X 2900 +RPS6KA1 p90RSK Q15418 human PDCD4 27250 Q53EL6 PDCD4 human S76 2588300 RDsGrGDsVsDsGsD X +RPS6KA1 p90RSK Q15418 human GMF-beta 2764 P60983 GMFB human T27 451486 KFRFRKEtNNAAIIM Cofilin_ADF X +RPS6KA1 p90RSK Q15418 human CDC34 997 P49427 CDC34 human T162 59049803 KGkDREYtDIIrkQV UQ_con X X +RPS6KA1 p90RSK Q15418 human MAGI1 9223 Q96QZ7 MAGI1 human S741 3896422 QPLERKDsQNSSQHs MAGI_u5 X +RPS6KA1 p90RSK Q15418 human EIF4B 1975 P23588 EIF4B human S422 451290 RERsRtGsEssQtGt X X 3591 +RPS6KA1 p90RSK Q15418 human S6 6194 P62753 RPS6 human S235 448092 IAKRRRLssLRAsts X X 5006; 4856; 4857; 4858; 4851; 4803; 2211; 3945; 3985; 5316; 4854; 8520; 48319; 40643; 9865; 38573; 14733; 27036; 34411; 62016; 62788; 81736; 97935; 99457; 15448 +RPS6KA1 p90RSK Q15418 human BAD 12015 Q61337 Bad mouse S136 447862 PFRGRsRsAPPNLWA Bcl-2_BAD X 9295; 5286; 4366 +RPS6KA1 p90RSK Q15418 human SENP2 59343 Q9HC62 SENP2 human T369 40499300 TDDLLELtEDMEKEI X +RPS6KA1 p90RSK Q15418 human DEPTOR 64798 Q8TB45 DEPTOR human S291 4723858 CGssGyFsssPtLss X X +RPS6KA1 p90RSK Q15418 human CdGAP 57514 Q2M1Z3 ARHGAP31 human S1178 484822 ALTGRRNsAPVsVsA X +RPS6KA1 p90RSK Q15418 human capicua 23152 Q96RK0 CIC human S173 3209781 PGKRRtQsLsALPKE X X +RPS6KA1 p90RSK Q15418 human CDC25A 993 P30304 CDC25A human S293 449128 GSTKrRKsMsGASPk M-inducer_phosp X X +RPS6KA1 p90RSK Q15418 human Raptor 57521 Q8N122 RPTOR human S722 2314601 PrLrsVssyGNIRAV X X +RPS6KA1 p90RSK Q15418 human GAB2 14389 Q9Z1S8 Gab2 mouse S211 4825112 TENARSAsFSQGTRQ X +EPHA7 EphA7 Q15375 human GLO1 2739 Q04760 GLO1 human Y136 463450 GIAVPDVysACkRFE Glyoxalase X +Braf BRAF F1M9C3 rat MEK1 170851 Q01986 Map2k1 rat S218 448514 VsGQLIDsMANsFVG Pkinase X 9121; 3958; 9154; 86128 +Braf BRAF F1M9C3 rat MEK1 170851 Q01986 Map2k1 rat S222 448513 LIDsMANsFVGTRSY Pkinase X 2338; 9121; 3958; 9154; 16211; 86128; 16780; 75262 +GRK1 GRK1 P28327 cow GRK1 281457 P28327 GRK1 cow S5 2528801 ___MDFGsLEtVVAN X +GRK1 GRK1 P28327 cow GRK1 281457 P28327 GRK1 cow T8 2528800 MDFGsLEtVVANSAF X +GRK1 GRK1 P28327 cow GRK1 281457 P28327 GRK1 cow T489 2530400 QDVGAFstVKGVAFE X X +GRK1 GRK1 P28327 cow GRK1 281457 P28327 GRK1 cow S488 2530401 IQDVGAFstVKGVAF X X +GRK1 GRK1 P28327 cow GRK1 281457 P28327 GRK1 cow S21 456353 AFIAARGsFDASSGP X +PDGFRA PDGFRA P16234 human PDGFRA 5156 P16234 PDGFRA human Y1018 448647 RLSADsGyIIPLPDI X 4547 +PDGFRA PDGFRA P16234 human PDGFRA 5156 P16234 PDGFRA human Y572 448437 IsPDGHEyIyVDPMQ X +PDGFRA PDGFRA P16234 human PDGFRA 5156 P16234 PDGFRA human Y988 450905 RVDSDNAyIGVtyKN X +PDGFRA PDGFRA P16234 human Daple 440193 Q9P219 CCDC88C human Y2025 899136400 PQTVWyEyGCV____ X +PDGFRA PDGFRA P16234 human Src 6714 P12931 SRC human Y419 448234 RLIEDNEytARQGAk PK_Tyr_Ser-Thr X 2101; 6943; 59548; 70926; 78740; 94361; 17320 +PDGFRA PDGFRA P16234 human PDGFRA 5156 P16234 PDGFRA human Y574 448438 PDGHEyIyVDPMQLP X +TAOK1 TAO1 Q7L7X3 human RhoE 390 P61587 RND3 human S210 27933600 KNVKRNKsQRATKRI X X +TAOK1 TAO1 Q7L7X3 human RhoE 390 P61587 RND3 human S218 25307985 QRATKRIsHMPsRPE X +TAOK1 TAO1 Q7L7X3 human TAO1 57551 Q7L7X3 TAOK1 human T440 23150854 RNREHFAtIRtAsLV X +TAOK1 TAO1 Q7L7X3 human LATS1 9113 O95835 LATS1 human T1079 457595 EHAFyEFtFRRFFDD X 8654 +TAOK1 TAO1 Q7L7X3 human TAO1 57551 Q7L7X3 TAOK1 human T443 1880716204 EHFAtIRtAsLVTRQ X +TAOK1 TAO1 Q7L7X3 human RhoE 390 P61587 RND3 human S240 27933601 LRKDKAKsCTVM___ X +TAOK1 TAO1 Q7L7X3 human SEPT7 989 Q16181 SEPTIN7 human T426 476328 EQQNssrtLEKNKKK X +TAOK1 TAO1 Q7L7X3 human TAO1 57551 Q7L7X3 TAOK1 human S181 7321740 SMAsPANsFVGtPyW Pkinase X +GRK2 GRK2 P25098 human Radixin 5962 P35241 RDX human T564 448374 AGRDKyKtLRQIRQG ERM_C X 3141; 3726; 32600 +GRK2 GRK2 P25098 human KOR-3 4987 P41146 OPRL1 human S346 1868135700 LRRDVQVsDRVRsIA X +GRK2 GRK2 P25098 human TRHR 25570 Q01717 Trhr rat S364 1229700 IKEsDRFstELDDIt X +GRK2 GRK2 P25098 human EDNRA 1909 P25101 EDNRA human S391 2911717 LCCCCyQsKsLMtsV X +GRK2 GRK2 P25098 human Ezrin 7430 P15311 EZR human T567 448104 QGRDkyKtLRQIRQG ERM_C X X 3141; 3726; 32600 +GRK2 GRK2 P25098 human ADRB2 154 P07550 ADRB2 human S396 457440 GHQGtVPsDNIDsQG X X +GRK2 GRK2 P25098 human NHE5 6553 Q14940 SLC9A5 human S712 20832301 EEEEsDssEtEKEDD X +GRK2 GRK2 P25098 human DOR-1 18386 P32300 Oprd1 mouse S363 448550 RVtACtPsDGPGGGA X +GRK2 GRK2 P25098 human TRHR 25570 Q01717 Trhr rat S360 1229701 NYsVIKEsDRFstEL X +GRK2 GRK2 P25098 human MOR-1 4988 P35372 OPRM1 human S377 447784 QNtRDHPstANtVDR X 3451 +GRK2 GRK2 P25098 human mAChR M2 1129 P08172 CHRM2 human T287 459103 KEssNDstsVsAVAs 7tm_1 X +GRK2 GRK2 P25098 human H1R 3269 P35367 HRH1 human S398 450937 WKRLRsHsRQyVSGL 7tm_1 X +GRK2 GRK2 P25098 human mAChR M2 1129 P08172 CHRM2 human S294 459112 tsVsAVAsNMRDDEI 7tm_1 X +GRK2 GRK2 P25098 human TUBB3 22152 Q9ERD7 Tubb3 mouse S444 451154 YEDDDEEsEAQGPK_ X +GRK2 GRK2 P25098 human SSTR2 P30680 Sstr2 rat T353 7652102 DKsRLNEttEtQRtL X +GRK2 GRK2 P25098 human RPLP2 140662 P02401 Rplp2 rat S105 454320 KKEEsEEsDDDMGFG Ribosomal_60s X +GRK2 GRK2 P25098 human NPFFR2 10886 Q9Y5X5 NPFFR2 human S520 36533409 LKEttNssEI_____ X +GRK2 GRK2 P25098 human MOR-1 18390 P42866 Oprm1 mouse T376 20727901 NtREHPstANtVDRT X +GRK2 GRK2 P25098 human mAChR M2 1129 P08172 CHRM2 human S288 459104 EssNDstsVsAVAsN 7tm_1 X +GRK2 GRK2 P25098 human ADRA1D 146 P25100 ADRA1D human S334 1424270003 HtFRssLsVRLLKFS 7tm_1 X +GRK2 GRK2 P25098 human Epac1 iso3 10411 O95398-3 RAPGEF3 human S108 54400804 GLGVHSRsQVVGICQ DEP X +GRK2 GRK2 P25098 human mAChR M2 1129 P08172 CHRM2 human S283 459120 QGEEKEssNDstsVs 7tm_1 X +GRK2 GRK2 P25098 human GPBAR1 151306 Q8TDU6 GPBAR1 human S324 1877729206 YHPSsQssVDLDLN_ X +GRK2 GRK2 P25098 human NHE5 6553 Q14940 SLC9A5 human S702 20832300 AVILTVEsEEEEEEs X +GRK2 GRK2 P25098 human GNRHR2 100399755 Q95MG6 LOC100399755 marmoset S339 454394 QELSMDssREEGSRR X +GRK2 GRK2 P25098 human ADRA1D 146 P25100 ADRA1D human S332 1424270006 KGHtFRssLsVRLLK 7tm_1 X +GRK2 GRK2 P25098 human KOR-3 4987 P41146 OPRL1 human S351 1868135701 QVsDRVRsIAKDVAL X +GRK2 GRK2 P25098 human mAChR M2 1129 P08172 CHRM2 human S234 459115 NQDPVsPsLVQGRIV 7tm_1 X +GRK2 GRK2 P25098 human NHE5 6553 Q14940 SLC9A5 human S711 20832303 EEEEEsDssEtEKED X +GRK2 GRK2 P25098 human P38A 1432 Q16539 MAPK14 human T123 471074 IVkCQkLtDDHVQFL Pkinase X X +GRK2 GRK2 P25098 human calsenilin 30818 Q9Y2W7 KCNIP3 human S95 471337 FTkKELQsLYRGFKN X +GRK2 GRK2 P25098 human DOR-1 4985 P41143 OPRD1 human T361 448551 RERVtACtPsDGPGG X +GRK2 GRK2 P25098 human mAChR M2 1129 P08172 CHRM2 human S290 459105 sNDstsVsAVAsNMR 7tm_1 X +GRK2 GRK2 P25098 human SSTR5 6755 P35346 SSTR5 human T333 27724400 GAKDADAtEPRPDRI X +GRK2 GRK2 P25098 human GPBAR1 151306 Q8TDU6 GPBAR1 human S323 1877729204 AYHPSsQssVDLDLN X +GRK2 GRK2 P25098 human ADIPOR1 51094 Q96A54 ADIPOR1 human T24 40263801 AsNREADtVELAELG X +GRK2 GRK2 P25098 human NHE5 6553 Q14940 SLC9A5 human S709 20832304 sEEEEEEsDssEtEK X +GRK2 GRK2 P25098 human ADRB2 11555 P18762 Adrb2 mouse S355 458916 KTYGNGYssNSNGRT X +GRK2 GRK2 P25098 human SSTR2 P30680 Sstr2 rat S341 7652103 GAEDGERsDsKQDKs X +GRK2 GRK2 P25098 human NPFFR2 10886 Q9Y5X5 NPFFR2 human T517 36533412 MEELKEttNssEI__ X +GRK2 GRK2 P25098 human CXCR4 12767 P70658 Cxcr4 mouse S354 12575201 VsTESEsssFHSs__ X +GRK2 GRK2 P25098 human NPFFR2 10886 Q9Y5X5 NPFFR2 human S519 36533407 ELKEttNssEI____ X +GRK2 GRK2 P25098 human Vinculin 22330 Q64727 Vcl mouse S721 3181157 DEAIDtksLLDAsEE Vinculin X +GRK2 GRK2 P25098 human SSTR2 P30680 Sstr2 rat S343 7652105 EDGERsDsKQDKsRL X +GRK2 GRK2 P25098 human IGF1R 3480 P08069 IGF1R human S1278 4271095 EPGFREVsFyySEEN X +GRK2 GRK2 P25098 human NHE5 6553 Q14940 SLC9A5 human T714 20832302 EEsDssEtEKEDDEG X +GRK2 GRK2 P25098 human ADRB2 11555 P18762 Adrb2 mouse S356 458917 TYGNGYssNSNGRTD X +GRK2 GRK2 P25098 human mAChR M2 1129 P08172 CHRM2 human T271 459118 KAPRDPVtENCVQGE 7tm_1 X +GRK2 GRK2 P25098 human SSTR2 P30680 Sstr2 rat T359 12577700 EttEtQRtLLNGDLQ X +GRK2 GRK2 P25098 human mAChR M2 1129 P08172 CHRM2 human S309 459107 tQDENtVstsLGHSK 7tm_1 X +GRK2 GRK2 P25098 human mAChR M2 1129 P08172 CHRM2 human S232 459114 VANQDPVsPsLVQGR 7tm_1 X +GRK2 GRK2 P25098 human mAChR M2 1129 P08172 CHRM2 human T307 459106 EItQDENtVstsLGH 7tm_1 X +GRK2 GRK2 P25098 human Radixin 19684 P26043 Rdx mouse T564 448374 AGRDKYKtLRQIRQG ERM_C X 3141; 3726; 32600 +GRK2 GRK2 P25098 human ADRB2 154 P07550 ADRB2 human S407 457443 DsQGRNCstNDsLL_ X X +GRK2 GRK2 P25098 human ADIPOR1 51094 Q96A54 ADIPOR1 human S7 40263802 _MSSHKGsVVAQGNG X +GRK2 GRK2 P25098 human mAChR M2 1129 P08172 CHRM2 human T302 459113 NMRDDEItQDENtVs 7tm_1 X +GRK2 GRK2 P25098 human TXA2-R iso2 6915 P21731-2 TBXA2R human S357 469629 RLPGSSDsRASASRA X +GRK2 GRK2 P25098 human TRHR 25570 Q01717 Trhr rat S355 1229702 YSVALNYsVIKEsDR X +GRK2 GRK2 P25098 human mAChR M2 1129 P08172 CHRM2 human S282 459119 VQGEEKEssNDstsV 7tm_1 X +GRK2 GRK2 P25098 human FZD6 8323 O60353 FZD6 human S648 1275585104 sVSESARsEGRIsPK X +GRK2 GRK2 P25098 human MOR-1 25601 P33535 Oprm1 rat S375 447784 QNtREHPsTANTVDR X +GRK2 GRK2 P25098 human SNCA 6622 P37840 SNCA human S129 448278 NEAyEMPsEEGyQDy Synuclein X X 23706; 87281 +GRK2 GRK2 P25098 human ADRA1D 146 P25100 ADRA1D human S300 1424270001 KRERGKAsEVVLRIH 7tm_1 X +GRK2 GRK2 P25098 human EDNRA 1909 P25101 EDNRA human S393 2911710 CCCyQsKsLMtsVPM X +GRK2 GRK2 P25098 human DOR-1 4985 P41143 OPRD1 human S363 448550 RVtACtPsDGPGGGA X +GRK2 GRK2 P25098 human TUBB 29214 P69897 Tubb5 rat S420 3146605 SNMNDLVsEYQQYQD X +GRK2 GRK2 P25098 human ADRB2 154 P07550 ADRB2 human S411 457444 RNCstNDsLL_____ X +GRK2 GRK2 P25098 human ADRB2 154 P07550 ADRB2 human S355 458916 KAyGNGyssNGNtGE X +GRK2 GRK2 P25098 human mAChR M2 1129 P08172 CHRM2 human S311 459109 DENtVstsLGHSKDE 7tm_1 X +GRK2 GRK2 P25098 human EDNRA 1909 P25101 EDNRA human S397 2911713 QsKsLMtsVPMNGts X +GRK2 GRK2 P25098 human TXA2-R iso2 6915 P21731-2 TBXA2R human S239 469628 AQQRPRDsEVEMMAQ 7tm_1 X +GRK2 GRK2 P25098 human ADRA1D 146 P25100 ADRA1D human S323 1424270002 DGAHGMRsAKGHtFR 7tm_1 X +GRK2 GRK2 P25098 human GHSR 2693 Q92847 GHSR human S252 1877127904 GDAVVGAsLRDQNHK 7tm_1 X +GRK2 GRK2 P25098 human mAChR M2 1129 P08172 CHRM2 human S250 459116 PNNNNMPssDDGLEH 7tm_1 X +GRK2 GRK2 P25098 human GPBAR1 151306 Q8TDU6 GPBAR1 human S321 1877729202 SIAYHPSsQssVDLD X +GRK2 GRK2 P25098 human KOR-3 4987 P41146 OPRL1 human S363 27150200 VALACKtsETVPRPA X +GRK2 GRK2 P25098 human GNRHR2 100399755 Q95MG6 LOC100399755 marmoset S338 454393 HQELSMDssREEGSR X +GRK2 GRK2 P25098 human mAChR M2 1129 P08172 CHRM2 human S251 459117 NNNNMPssDDGLEHN 7tm_1 X +GRK2 GRK2 P25098 human SSTR2 P30680 Sstr2 rat T356 12577701 RLNEttEtQRtLLNG X +GRK2 GRK2 P25098 human CLTB 1212 P09497 CLTB human S205 25592003 LCDFNPksSkQCKDV Clathrin_lg_ch X X +GRK2 GRK2 P25098 human GPBAR1 151306 Q8TDU6 GPBAR1 human S310 1877729200 WGRASRDsPGPSIAY X +GRK2 GRK2 P25098 human NPFFR2 10886 Q9Y5X5 NPFFR2 human T516 36533408 VMEELKEttNssEI_ X +GRK2 GRK2 P25098 human SSTR2 P30680 Sstr2 rat T354 7652101 KsRLNEttEtQRtLL X +GRK2 GRK2 P25098 human MOR-1 18390 P42866 Oprm1 mouse T370 447785 sARIRQNtREHPstA X +GRK2 GRK2 P25098 human MOR-1 18390 P42866 Oprm1 mouse S375 447784 QNtREHPstANtVDR X 3451 +GRK2 GRK2 P25098 human ADRB2 154 P07550 ADRB2 human S401 457441 VPsDNIDsQGRNCst X +GRK2 GRK2 P25098 human mAChR M2 1129 P08172 CHRM2 human T310 459108 QDENtVstsLGHSKD 7tm_1 X +GRK2 GRK2 P25098 human Moesin 4478 P26038 MSN human T558 447706 LGRDKyKtLRQIRQG ERM_C X 3141; 3726; 32600 +GRK2 GRK2 P25098 human ADRB2 154 P07550 ADRB2 human S356 458917 AyGNGyssNGNtGEQ X +GRK2 GRK2 P25098 human mAChR M2 1129 P08172 CHRM2 human S286 459101 EKEssNDstsVsAVA 7tm_1 X +GRK2 GRK2 P25098 human EDNRA 1909 P25101 EDNRA human T396 2911714 yQsKsLMtsVPMNGt X +GRK2 GRK2 P25098 human CMKOR1 12778 P56485 Ackr3 mouse T352 4709314 DAsRVsEtEysALEQ X +GRK2 GRK2 P25098 human ADRA1D 146 P25100 ADRA1D human S516 1346843003 QLRAKVssLsHKIRA X +GRK2 GRK2 P25098 human SMAD2 4087 Q15796 SMAD2 human T197 25586400 LPPLDDYtHSIPENT X +GRK2 GRK2 P25098 human CMKOR1 12778 P56485 Ackr3 mouse S350 4709309 LIDAsRVsEtEysAL X +GRK2 GRK2 P25098 human ADRB2 154 P07550 ADRB2 human T384 457437 LCEDLPGtEDFVGHQ X +GRK2 GRK2 P25098 human EDNRA 1909 P25101 EDNRA human S404 2911711 sVPMNGtsIQWKNHD X +GRK2 GRK2 P25098 human ADRA1D 146 P25100 ADRA1D human S518 1346843000 RAKVssLsHKIRAGG X +GRK2 GRK2 P25098 human ADIPOR1 51094 Q96A54 ADIPOR1 human S205 1877164900 EKVSRTFsKLDYSGI HlyIII X +GRK2 GRK2 P25098 human CXCR4 12767 P70658 Cxcr4 mouse S353 7997136 sVsTESEsssFHSs_ X +GRK2 GRK2 P25098 human KOR-3 4987 P41146 OPRL1 human T362 1868135702 DVALACKtsETVPRP X +GRK2 GRK2 P25098 human TUBB 29214 P69897 Tubb5 rat T409 3146606 GMDEMEFtEAESNMN X +GRK2 GRK2 P25098 human MOR-1 18390 P42866 Oprm1 mouse T379 20727900 EHPstANtVDRTNHQ X +GRK2 GRK2 P25098 human TRHR 25570 Q01717 Trhr rat T365 465592 KEsDRFstELDDItV X X +GRK2 GRK2 P25098 human RPLP2 140662 P02401 Rplp2 rat S102 454319 KDEKKEEsEEsDDDM Ribosomal_60s X +GRK2 GRK2 P25098 human p53 7157 P04637 TP53 human T55 450685 DDIEQWFtEDPGPDE TAD2 X +GRK2 GRK2 P25098 human ADIPOR1 51094 Q96A54 ADIPOR1 human T53 40263803 PKAEEEQtCPVPQEE X +GRK2 GRK2 P25098 human EDNRA 1909 P25101 EDNRA human T403 2911712 tsVPMNGtsIQWKNH X +NPM/ALK NPM-ALK AAA58698 human PKM 5315 P14618 PKM human Y105 450528 FAsDPILyRPVAVAL PK X X 3827 +NPM/ALK NPM-ALK AAA58698 human NIPA 232679 Q80YV2 Zc3hc1 mouse S353 449745 PIVsRtRsWEsssPV X +NPM/ALK NPM-ALK AAA58698 human MSH2 4436 P43246 MSH2 human Y238 36121371 DFSTkDIyQDLNRLL MutS_II X +NPM/ALK NPM-ALK AAA58698 human WASP 7454 P42768 WAS human Y102 60110900 LLWEQELySQLVYST WH1 X +NPM/ALK NPM-ALK AAA58698 human WASP 7454 P42768 WAS human Y291 447985 AEtsKLIyDFIEDQG PBD X X +NPM/ALK NPM-ALK AAA58698 human STAT1 6772 P42224 STAT1 human Y701 447754 DGPkGtGyIktELIs X 9174; 9167; 5375; 25685; 8062; 8183; 8009; 55603; 7649; 25809; 57216; 45118; 39205; 88845; 88211; 76285; 90145 +MAP3K2 MEKK2 Q9Y2U5 human CTNNB1 1499 P35222 CTNNB1 human S675 457120 QDykKRLsVELtsSL X 9567; 4176; 68076 +MAP3K2 MEKK2 Q9Y2U5 human NDR1 11329 Q15208 STK38 human S91 1869478300 LGLEDFEsLkVIGRG Pkinase X X +MAP3K2 MEKK2 Q9Y2U5 human ANKRD3 72388 Q9ERK0 Ripk4 mouse T184 2926100 SMDGLFGtIAYLPPE Pkinase X X +MAP3K2 MEKK2 Q9Y2U5 human p47phox 17969 Q09014 Ncf1 mouse S208 465580 KRGWVPAsYLEPLDS X X +MAP3K2 MEKK2 Q9Y2U5 human IRF3 3661 Q14653 IRF3 human S173 6370303 PCPQPLRsPsLDNPt X +PRKAB1 AMPKB1 Q9Y478 human SF2 6426 Q07955 SRSF1 human S133 15178110 SGLPPSGsWQDLkDH RRM_1 X +PRKAB1 AMPKB1 Q9Y478 human STIM1 361618 P84903 Stim1 rat S257 468872 GLHRAEQsLHDLQER X +PRKAB1 AMPKB1 Q9Y478 human PDHA1 5160 P08559 PDHA1 human S295 468391 RyHGHsMsDPGVsyR E1_dh X +PRKAB1 AMPKB1 Q9Y478 human PROX1 5629 Q92786 PROX1 human S79 487308 KLLKRANsyEDAMMP X +PRKAB1 AMPKB1 Q9Y478 human SKP2 27401 Q9Z0Z3 Skp2 mouse S256 1296362400 ATLLSSCsRLDELNL X +PRKAB1 AMPKB1 Q9Y478 human Oct1 5451 P14859 POU2F1 human S335 10424763 RFEALNLsFKNMCKL Pou X +PRKAB1 AMPKB1 Q9Y478 human STIM1 361618 P84903 Stim1 rat S521 468874 RDLtHsDsESSLHTS X +PRKAB1 AMPKB1 Q9Y478 human PDHA1 5160 P08559 PDHA1 human S314 1868287349 IQEVRSksDPIMLLk E1_dh X +PRKAB1 AMPKB1 Q9Y478 human STIM1 6786 Q13586 STIM1 human S521 468874 RDLtHsDsEssLHMs X X +PRKAB1 AMPKB1 Q9Y478 human STIM1 6786 Q13586 STIM1 human S257 468872 GLHRAEQsLHDLQER X X +PRKAB1 AMPKB1 Q9Y478 human ARK2N 212163 Q8BH50 Ark2n mouse S67 485212 MELRRDssEsQLAst RNF111_N X X +PRKAB1 AMPKB1 Q9Y478 human SKP2 6502 Q13309 SKP2 human S256 1296362400 QTLLSSCsRLDELNL X +PRKAB1 AMPKB1 Q9Y478 human NEDD4L 23327 Q96PU5 NEDD4L human S795 18963100 VDLKPNGsEIMVTNE HECT X +MAP2K2 MEK2 P36507 human K8 3856 P05787 KRT8 human S74 448539 tVNQsLLsPLVLEVD Keratin_2_head X +MAP2K2 MEK2 P36507 human ERK1 5595 P27361 MAPK3 human T202 447542 HDHtGFLtEyVAtRW Pkinase X X 9106; 4370; 4374; 9101; 4375; 4376; 4377; 3510; 5726; 88569; 13214; 13148; 70235; 9488; 89967; 8544; 14196; 14227; 14095; 14474; 75165; 98168; 33370; 54240; 15892; 45899; 55088; 9524; 69217; 48735 +MAP2K2 MEK2 P36507 human ERK1 5595 P27361 MAPK3 human Y204 447543 HtGFLtEyVAtRWyr Pkinase X X 9106; 4370; 4374; 9101; 4375; 4376; 4377; 3510; 5726; 88569; 13214; 13148; 70235; 9488; 89967; 8544; 14196; 14227; 14095; 14474; 75165; 98168; 33370; 54240; 15892; 45899; 55088; 9524; 69217; 48735 +Pdgfra PDGFRA P26618 mouse PKACA 18747 P05132 Prkaca mouse Y331 15230353 DTSNFDDyEEEEIRV X +Dyrk1a DYRK1A Q61214 mouse GSK3B 56637 Q9WV60 Gsk3b mouse T356 37043704 KLPNGRDtPALFNFT X X +Dyrk1a DYRK1A Q61214 mouse Tau iso8 4137 P10636-8 MAPT human S404 449082 PVVsGDtsPRHLsNV X 35834; 20194; 98523; 91600; 49562 +Dyrk1a DYRK1A Q61214 mouse STXBP1 20910 O08599 Stxbp1 mouse T479 25698802 TyQLSRWtPIIkDIM Sec1 X X +Dyrk1a DYRK1A Q61214 mouse CRY2 12953 Q9R194 Cry2 mouse S557 456803 ALSsGPAsPKRKLEA X X +Dyrk1a DYRK1A Q61214 mouse PSEN1 5663 P49768 PSEN1 human T354 451669 HLGPHRstPEsRAAV Presenilin X +Dyrk1a DYRK1A Q61214 mouse Tau iso8 4137 P10636-8 MAPT human S202 447928 sGyssPGsPGtPGsR X 39357; 30505 +Dyrk1a DYRK1A Q61214 mouse CASP9 12371 Q8C3Q9 Casp9 mouse T163 449563 PEVLRPEtPRPVDIG X +Dyrk1a DYRK1A Q61214 mouse GYS1 100008660 P13834 GYS1 rabbit S641 448237 YRYPRPAsVPPsPSL Glycogen_syn X +JAK3 JAK3 P52333 human STAT5A 6776 P42229 STAT5A human Y694 447767 LAkAVDGyVkPQIkQ X 9365; 9356; 9359; 9351; 4322; 9314; 3939; 40284; 5387; 14603; 66740; 51879; 72712 +JAK3 JAK3 P52333 human JAK1 3716 P23458 JAK1 human Y1034 448451 AIEtDkEyytVkDDR PK_Tyr_Ser-Thr X 3331; 74129; 66245; 32901 +JAK3 JAK3 P52333 human CTNNB1 1499 P35222 CTNNB1 human Y86 447584 VADIDGQyAMTRAQR X X +JAK3 JAK3 P52333 human CTNNB1 1499 P35222 CTNNB1 human Y30 462001 sHWQQQsyLDsGIHs X X +JAK3 JAK3 P52333 human Siglec-10 89790 Q96LC7 SIGLEC10 human Y597 450086 RHstILDyINVVPTA X +JAK3 JAK3 P52333 human CTNNB1 1499 P35222 CTNNB1 human Y64 12170302 VDTsQVLyEWEQGFS X X +JAK3 JAK3 P52333 human HuR 1994 Q15717 ELAVL1 human Y68 29606700 LGyGFVNyVTAkDAE RRM_1 X +JAK3 JAK3 P52333 human JAK3 3718 P52333 JAK3 human Y980 447636 LLPLDkDyyVVREPG PK_Tyr_Ser-Thr X X 5031; 32901 +JAK3 JAK3 P52333 human HuR 1994 Q15717 ELAVL1 human Y200 460123 VALLsQLyHsPArrF X +JAK3 JAK3 P52333 human JAK3 3718 P52333 JAK3 human Y939 2197000 QICkGMEyLGSRRCV PK_Tyr_Ser-Thr X X +JAK3 JAK3 P52333 human PLD2 5338 O14939 PLD2 human Y415 10036101 ALGINSGysKRALML X X +JAK3 JAK3 P52333 human EZH2 2146 Q15910 EZH2 human Y244 59087901 AEELKEKyKELTEQQ PRC2_HTH_1 X +JAK3 JAK3 P52333 human NFAT2 4772 O95644 NFATC1 human Y371 27427900 ADFAPEDySSFQHIR X X +JAK3 JAK3 P52333 human JAK3 3718 P52333 JAK3 human Y785 450358 NSLIsSDyELLSDPT X X +JAK3 JAK3 P52333 human JAK3 3718 P52333 JAK3 human Y904 2197001 SLRLVMEyLPSGCLR PK_Tyr_Ser-Thr X X +JAK3 JAK3 P52333 human Siglec-10 89790 Q96LC7 SIGLEC10 human Y667 450087 ESQEELHyATLNFPG X +JAK3 JAK3 P52333 human SHC1 iso2 6464 P29353-2 SHC1 human Y410 23144113 STTTPGQyVLTGLQS SH2 X +JAK3 JAK3 P52333 human SHC1 iso2 6464 P29353-2 SHC1 human Y448 33664400 SVSHLISyHMDNHLP SH2 X +JAK3 JAK3 P52333 human HuR 1994 Q15717 ELAVL1 human Y63 472818 VAGHSLGyGFVNyVT RRM_1 X +JAK3 JAK3 P52333 human JAK1 3716 P23458 JAK1 human Y1035 448452 IEtDkEyytVkDDRD PK_Tyr_Ser-Thr X 3331; 74129; 66245; 32901 +JAK3 JAK3 P52333 human JAK3 3718 P52333 JAK3 human Y981 447637 LPLDkDyyVVREPGQ PK_Tyr_Ser-Thr X X 5031; 32901 +JAK3 JAK3 P52333 human Siglec-10 89790 Q96LC7 SIGLEC10 human Y691 450088 PKGTQADyAEVKFQ_ X +JAK3 JAK3 P52333 human STAT1 6772 P42224 STAT1 human Y701 447754 DGPkGtGyIktELIs X X 9174; 9167; 5375; 25685; 8062; 8183; 8009; 55603; 7649; 25809; 57216; 45118; 39205; 88845; 88211; 76285; 90145 +PFKFB3 PFKFB3 Q16875 human HER2 2064 P04626 ERBB2 human S1151 3178974 DVRPQPPsPREGPLP X +ITK ITK Q08881 human DEF6 50619 Q9H4E7 DEF6 human Y222 18505504 QDVLKQGyLWkRGHL PH X +ITK ITK Q08881 human Etk 660 P51813 BMX human Y216 449835 SSTSLAQyDSNSKKI X +ITK ITK Q08881 human Siglec-10 89790 Q96LC7 SIGLEC10 human Y597 450086 RHstILDyINVVPTA X +ITK ITK Q08881 human TIM-3 84868 Q8TDQ0 HAVCR2 human Y265 470136 IRSEENIyTIEENVy X +ITK ITK Q08881 human SLP76 3937 Q13094 LCP2 human Y173 456736 FPNsNsMyIDRPPSG X X +ITK ITK Q08881 human TEC 7006 P42680 TEC human Y206 449836 RLERGQEyLILEKND SH3_1 X +ITK ITK Q08881 human DEF6 50619 Q9H4E7 DEF6 human Y210 25687500 SMAIHEVyQELIQDV X +ITK ITK Q08881 human PLCG1 18803 Q62077 Plcg1 mouse Y783 447667 EGRNPGFyVEANPMP X 2821; 14461; 14008; 25678; 88717 +ITK ITK Q08881 human Btk 695 Q06187 BTK human Y223 447485 LKKVVALyDyMPMNA SH3_1 X 5082; 87141; 87457 +ITK ITK Q08881 human ITK 3702 Q08881 ITK human Y180 449834 ETVVIALyDyQtNDP SH3_1 X X +ITK ITK Q08881 human GADS 9402 O75791 GRAP2 human Y45 451894 ELGsQEGyVPkNFID SH3_1 X X +ITK ITK Q08881 human PLCG1 5335 P19174 PLCG1 human Y783 447667 EGRNPGFyVEANPMP X X 2821; 14461; 14008; 25678; 88717 +ITK ITK Q08881 human Siglec-10 89790 Q96LC7 SIGLEC10 human Y667 450087 ESQEELHyATLNFPG X +LMTK2 Lmr2 Q8IWU2 human PPP1CA 5499 P62136 PPP1CA human T320 448686 NPGGRPItPPRNsAK X 2581 +LMTK2 Lmr2 Q8IWU2 human CFTR 1080 P13569 CFTR human S737 449981 EPLERRLsLVPDSEQ CFTR_R X +LMTK2 Lmr2 Q8IWU2 human PPP1CA 100009298 P62139 PPP1CA rabbit T320 448686 NPGGRPItPPRNsAK X +LMTK2 Lmr2 Q8IWU2 human PYGB 5834 P11216 PYGB human S15 456885 sEkRKQIsVRGLAGL X +Csnk1d CK1D Q9DC28 mouse PER2 18627 O54943 Per2 mouse S91 470045 tEAEHNPstSGCSSE X +Csnk1d CK1D Q9DC28 mouse PER2 18627 O54943 Per2 mouse T964 470063 PVtPPAGtVALGRAs X +Csnk1d CK1D Q9DC28 mouse PER2 18627 O54943 Per2 mouse T71 470043 MLVESsNtHPsPDDA X +Csnk1d CK1D Q9DC28 mouse PER2 18627 O54943 Per2 mouse S693 468399 ETVEDMAsGPEsLDG X +Csnk1d CK1D Q9DC28 mouse PER2 18627 O54943 Per2 mouse S776 470019 NtSGLESsWKKTGKN X +Csnk1d CK1D Q9DC28 mouse PER2 18627 O54943 Per2 mouse T1237 470064 PsPGLCDtsEAKEEE X +Csnk1d CK1D Q9DC28 mouse PER2 18627 O54943 Per2 mouse S528 470011 IQtKsHVsHEsGGQK X +Csnk1d CK1D Q9DC28 mouse PER2 18627 O54943 Per2 mouse T800 470055 tRDssEstGsGGPVs X +Csnk1d CK1D Q9DC28 mouse PER2 18627 O54943 Per2 mouse S538 470013 sGGQKEAsVAEMQss X +Csnk1d CK1D Q9DC28 mouse PER2 18627 O54943 Per2 mouse S659 449331 TLPGKAEsVVsLTSQ X X +Csnk1d CK1D Q9DC28 mouse PER2 18627 O54943 Per2 mouse S997 470024 LEEAPEGstGAAGTL X +Csnk1d CK1D Q9DC28 mouse PER2 18627 O54943 Per2 mouse S662 470017 GKAEsVVsLTSQCSY X +Csnk1d CK1D Q9DC28 mouse PER2 18627 O54943 Per2 mouse T92 470046 EAEHNPstSGCSSEQ X +Csnk1d CK1D Q9DC28 mouse PER2 18627 O54943 Per2 mouse T84 470044 DAFRLMMtEAEHNPs X +Csnk1d CK1D Q9DC28 mouse PER2 18627 O54943 Per2 mouse T554 470047 PAQVKAVtTIERDSS X +Csnk1d CK1D Q9DC28 mouse PER2 18627 O54943 Per2 mouse S933 470061 PAHPTLAsEITPAsQ X +Csnk1d CK1D Q9DC28 mouse PER2 18627 O54943 Per2 mouse S531 470012 KsHVsHEsGGQKEAs X +Csnk1d CK1D Q9DC28 mouse PER2 18627 O54943 Per2 mouse S69 470042 LRMLVESsNtHPsPD X +Csnk1d CK1D Q9DC28 mouse PER2 18627 O54943 Per2 mouse S697 468400 DMAsGPEsLDGAAGG X +Csnk1d CK1D Q9DC28 mouse PER2 18627 O54943 Per2 mouse S980 470022 PLFQSRGssPLQLNL X +Csnk1d CK1D Q9DC28 mouse PER2 18627 O54943 Per2 mouse S618 470048 EFPANIPsRKAtVsP X +Csnk1d CK1D Q9DC28 mouse PER2 18627 O54943 Per2 mouse S939 470062 AsEITPAsQAEFPSR X +Csnk1d CK1D Q9DC28 mouse VANGL2 93840 Q91ZD4 Vangl2 mouse S84 18460401 GTSEHsIsHDDLTRI Strabismus X +Csnk1d CK1D Q9DC28 mouse PER2 18627 O54943 Per2 mouse T793 470052 LKSKRVKtRDssEst X +Csnk1d CK1D Q9DC28 mouse PER2 18627 O54943 Per2 mouse T622 470049 NIPsRKAtVsPGLHS X +Csnk1d CK1D Q9DC28 mouse PER2 18627 O54943 Per2 mouse S545 470015 sVAEMQssPPAQVKA X +Csnk1d CK1D Q9DC28 mouse PER2 18627 O54943 Per2 mouse S797 470066 RVKtRDssEstGsGG X +Csnk1d CK1D Q9DC28 mouse PER2 18627 O54943 Per2 mouse T998 470025 EEAPEGstGAAGTLG X +Csnk1d CK1D Q9DC28 mouse PER2 18627 O54943 Per2 mouse S624 470016 PsRKAtVsPGLHSGE X +Csnk1d CK1D Q9DC28 mouse PER2 18627 O54943 Per2 mouse S1238 470065 sPGLCDtsEAKEEEG X +Csnk1d CK1D Q9DC28 mouse PER2 18627 O54943 Per2 mouse S763 470018 ERsRAQAsDRGLRNt X +Csnk1d CK1D Q9DC28 mouse PER2 18627 O54943 Per2 mouse T866 470059 VVAPPAAtHtGFTMP X +Csnk1d CK1D Q9DC28 mouse CTNNB1 12387 Q02248 Ctnnb1 mouse S45 447488 GATtTAPsLsGkGNP X 9565; 9564; 24710; 70034; 19807; 96727; 77605 +Csnk1d CK1D Q9DC28 mouse PER2 18627 O54943 Per2 mouse T868 470060 APPAAtHtGFTMPVV X +Csnk1d CK1D Q9DC28 mouse PER2 18627 O54943 Per2 mouse S544 470014 AsVAEMQssPPAQVK X +Csnk1d CK1D Q9DC28 mouse CTNNB1 12387 Q02248 Ctnnb1 mouse S47 34606438 TtTAPsLsGkGNPEE X +Csnk1d CK1D Q9DC28 mouse PER2 18627 O54943 Per2 mouse S802 470056 DssEstGsGGPVsHR X +Csnk1d CK1D Q9DC28 mouse PER2 18627 O54943 Per2 mouse S796 470053 KRVKtRDssEstGsG X +Csnk1d CK1D Q9DC28 mouse PER2 18627 O54943 Per2 mouse S981 470023 LFQSRGssPLQLNLL X +Csnk1d CK1D Q9DC28 mouse PER2 18627 O54943 Per2 mouse T770 470051 sDRGLRNtSGLESsW X +Csnk1d CK1D Q9DC28 mouse VANGL2 93840 Q91ZD4 Vangl2 mouse S5 18460402 ___MDTEsQysGySY X +Csnk1d CK1D Q9DC28 mouse DNMT1 13433 P13864 Dnmt1 mouse S146 4702934 ksDsDtLsVEtsPss X +Csnk1d CK1D Q9DC28 mouse PER2 18627 O54943 Per2 mouse S525 470010 SGKIQtKsHVsHEsG X +Csnk1d CK1D Q9DC28 mouse PER2 18627 O54943 Per2 mouse T858 470058 GIVSTPGtVVAPPAA X +Csnk1d CK1D Q9DC28 mouse PER2 18627 O54943 Per2 mouse S758 470050 QNYLQERsRAQAsDR X +Csnk1d CK1D Q9DC28 mouse VANGL2 93840 Q91ZD4 Vangl2 mouse S82 18460400 VTGTSEHsIsHDDLT Strabismus X +Csnk1d CK1D Q9DC28 mouse PER2 18627 O54943 Per2 mouse S807 470057 tGsGGPVsHRPPLMG X +Csnk1d CK1D Q9DC28 mouse PER2 18627 O54943 Per2 mouse S799 470054 KtRDssEstGsGGPV X +Csnk1d CK1D Q9DC28 mouse PER2 18627 O54943 Per2 mouse S971 470021 tVALGRAsPPLFQSR X +CLK3 CLK3 P49761 human USP13 8975 Q92995 USP13 human Y708 1868989003 EPLTMPGyGGAASAG UCH X X +CSK CSK P41240 human EEF2 1938 P13639 EEF2 human Y265 457573 kkLWGDryFDPANGk GTP_EFTU X +CSK CSK P41240 human Yes 7525 P07947 YES1 human Y537 447620 FtAtEPQyQPGENL_ X +CSK CSK P41240 human CD45 5788 P08575 PTPRC human Y1218 451644 MVSTFEQyQFLyDVI Y_phosphatase X X +CSK CSK P41240 human Lck 3932 P06239 LCK human Y505 447823 FTAtEGQyQPQP___ X 2751; 37458 +CSK CSK P41240 human Src 6714 P12931 SRC human Y530 448235 FTstEPQyQPGENL_ X X 2105 +CSK CSK P41240 human Src 396442 P00523 SRC chicken Y527 448235 FTSTEPQyQPGENL_ X X 2105 +CSK CSK P41240 human P2X3 81739 P49654 P2rx3 rat Y393 9486200 QStDSGAySIGH___ X X +CSK CSK P41240 human Hck 3055 P08631 HCK human Y411 448168 RVIEDNEytAREGAk PK_Tyr_Ser-Thr X 2101; 6943; 59548; 70926; 78740; 94361; 17320 +CSK CSK P41240 human Src iso1 20779 P05480-1 Src mouse Y535 448235 FTSTEPQyQPGENL_ X 2105 +CSK CSK P41240 human Tau iso8 4137 P10636-8 MAPT human Y29 4103318 DRKDQGGytMHQDQE X +CSK CSK P41240 human Tau iso8 4137 P10636-8 MAPT human Y197 464351 KsGDRsGyssPGsPG X +CSK CSK P41240 human EEF2 1938 P13639 EEF2 human Y373 459352 kYRCELLyEGPPDDE X +CSK CSK P41240 human Src 6714 P12931 SRC human Y419 448234 RLIEDNEytARQGAk PK_Tyr_Ser-Thr X 2101; 6943; 59548; 70926; 78740; 94361; 17320 +CSK CSK P41240 human Fyn 2534 P06241 FYN human Y531 447883 FtAtEPQyQPGENL_ X +Prkd1 PRKD1 Q9WTQ1 rat CDH2 83501 Q9Z1Y3 Cdh2 rat S871 382737700 GSTAGsLssLNSSSS CADH_Y-type_LIR X X +Prkd1 PRKD1 Q9WTQ1 rat TRPV1 83810 O35433 Trpv1 rat S116 454886 PRLYDRRsIFDAVAQ X +Prkd1 PRKD1 Q9WTQ1 rat CDH2 83501 Q9Z1Y3 Cdh2 rat S872 382737702 STAGsLssLNSSSSG CADH_Y-type_LIR X X +Prkd1 PRKD1 Q9WTQ1 rat DRP1 114114 O35303 Dnm1l rat S656 483971 VPVARKLsAREQRDC X 4867; 6319 +Prkd1 PRKD1 Q9WTQ1 rat CDH2 83501 Q9Z1Y3 Cdh2 rat S869 382737701 GSGSTAGsLssLNSS CADH_Y-type_LIR X X +Prkd1 PRKD1 Q9WTQ1 rat PRKD1 85421 Q9WTQ1 Prkd1 rat S916 447632 KALSERVsIL_____ X X +MAPK7 ERK5 Q13164 human neurogenin 1 29410 P70595 Neurog1 rat S179 7590801 PCLPGPPsPASDTES X X +MAPK7 ERK5 Q13164 human ERK5 5598 Q13164 MAPK7 human S774 14561006 QADsAsLsAsLLADW X +MAPK7 ERK5 Q13164 human Fos 2353 P01100 FOS human T232 448491 GGLPEVAtPESEEAF X +MAPK7 ERK5 Q13164 human MEF2A 4205 Q02078 MEF2A human T319 448098 tPVVSVTtPSLPPQG X X +MAPK7 ERK5 Q13164 human MEK5 5607 Q13163 MAP2K5 human S149 455512 sNSLkKssAELKkIL X +MAPK7 ERK5 Q13164 human ERK5 5598 Q13164 MAPK7 human S772 21560204 DGQADsAsLsAsLLA X +MAPK7 ERK5 Q13164 human MEK5 5607 Q13163 MAP2K5 human S129 455509 VNTrAGPsQHSsPAV X +MAPK7 ERK5 Q13164 human neurogenin 1 29410 P70595 Neurog1 rat S208 7590802 SPLSDPSsPSASEDF X X +MAPK7 ERK5 Q13164 human MEF2A 4205 Q02078 MEF2A human S355 449934 SALQGFNsPGMLSLG X X +MAPK7 ERK5 Q13164 human SGK1 6446 O00141 SGK1 human S78 448430 ANPsPPPsPsQQINL X X 5599 +MAPK7 ERK5 Q13164 human MEK5 5607 Q13163 MAP2K5 human S137 455510 QHSsPAVsDSLPsNS X +MAPK7 ERK5 Q13164 human Ets-1 2113 P14921 ETS1 human T38 447950 CADVPLLtPSSkEMM X X +MAPK7 ERK5 Q13164 human ERK5 5598 Q13164 MAPK7 human S770 14561007 PQDGQADsAsLsAsL X +MAPK7 ERK5 Q13164 human ERK5 5598 Q13164 MAPK7 human T733 455520 LPPVFsGtPKGSGAG X X +MAPK7 ERK5 Q13164 human PML 5371 P29590 PML human S403 3189643 AAVskkAsPEAAstP DUF3583 X +MAPK7 ERK5 Q13164 human ERK5 5598 Q13164 MAPK7 human S731 455519 DPLPPVFsGtPKGSG X X +MAPK7 ERK5 Q13164 human ERK5 5598 Q13164 MAPK7 human S496 455518 SRLRDGPsAPLEAPE X +MAPK7 ERK5 Q13164 human Fos 2353 P01100 FOS human S32 470080 DSLSYyHsPADSFSS X 5348; 8709; 8677; 99325 +MAPK7 ERK5 Q13164 human GJA1 24392 P08050 Gja1 rat S255 448852 HATTGPLsPskDCGs X X +MAPK7 ERK5 Q13164 human MEF2D 17261 Q63943 Mef2d mouse S180 449933 LTDPRLLsPQQPALQ X X +MAPK7 ERK5 Q13164 human ERK5 5598 Q13164 MAPK7 human S421 455516 CPDVEMPsPWAPSGD X +MAPK7 ERK5 Q13164 human MEF2A 4205 Q02078 MEF2A human T312 448097 QATQPLAtPVVSVTt X X +MAPK7 ERK5 Q13164 human ERK5 5598 Q13164 MAPK7 human T28 455514 VkAEPAHtAAsVAAk X +MAPK7 ERK5 Q13164 human DLG1 1739 Q12959 DLG1 human S158 2024309 FVsHsHIsPIKPTEA MAGUK_N_PEST X +MAPK7 ERK5 Q13164 human MEK5 5607 Q13163 MAP2K5 human S142 455511 AVsDSLPsNSLkKss X +MAPK7 ERK5 Q13164 human MEF2C iso3 4208 Q06413-3 MEF2C human S387 1729600 TRHEAGRsPVDSLSS X X +MAPK7 ERK5 Q13164 human NFAT3 73181 Q8K120 Nfatc4 mouse S170 448860 GGAFFsPsPGSSSLS X +MAPK7 ERK5 Q13164 human Myc 4609 P01106 MYC human S77 448586 LLPtPPLsPsRRsGL Myc_N X X 13748 +MAPK7 ERK5 Q13164 human SMURF2 66313 A2A5Z6 Smurf2 mouse T249 27457334 MSRTHLHtPPDLPEG X +MAPK7 ERK5 Q13164 human PML 5371 P29590 PML human T409 469197 AsPEAAstPRDPIDV DUF3583 X +MAPK7 ERK5 Q13164 human ERK5 5598 Q13164 MAPK7 human S433 455517 SGDCAMEsPPPAPPP X +MAPK7 ERK5 Q13164 human NFAT3 73181 Q8K120 Nfatc4 mouse S168 448859 QGGGAFFsPsPGSSS X +HIPK2 HIPK2 Q9H2X6 human HIPK2 28996 Q9H2X6 HIPK2 human T838 7447086 SKRVKENtPPRCAMV X +HIPK2 HIPK2 Q9H2X6 human PAX6 18508 P63015 Pax6 mouse T373 458810 GRSYDTYtPPHMQTH X X +HIPK2 HIPK2 Q9H2X6 human ZBTB4 57659 Q9P1Z0 ZBTB4 human T797 9184306 ERPGGtPtPVIAYsK X +HIPK2 HIPK2 Q9H2X6 human p53 22059 P02340 Tp53 mouse S58 2624500 EEFFEGPsEALRVSG X +HIPK2 HIPK2 Q9H2X6 human KLF3 51274 P57682 KLF3 human S78 4728755 sPPsAGNsPSSLKFP X +HIPK2 HIPK2 Q9H2X6 human PAX6 18508 P63015 Pax6 mouse T304 458809 QPIPQPTtPVsSFTS X X +HIPK2 HIPK2 Q9H2X6 human SIAH2 6478 O43255 SIAH2 human S68 5393502 GGGAGPVsPQHHELT X +HIPK2 HIPK2 Q9H2X6 human HMGA1 3159 P17096 HMGA1 human T78 451516 ktrkttttPGrkPrG X +HIPK2 HIPK2 Q9H2X6 human HIPK2 28996 Q9H2X6 HIPK2 human S827 7447082 SSSQAIssPQRSKRV X +HIPK2 HIPK2 Q9H2X6 human PAX6 18508 P63015 Pax6 mouse T281 458808 QRRQASNtPSHIPIS X X +HIPK2 HIPK2 Q9H2X6 human CTBP1 1487 Q13363 CTBP1 human S422 455350 AHPPHAPsPGQTVkP X X +HIPK2 HIPK2 Q9H2X6 human PML 5371 P29590 PML human S36 451469 PSEGRQPsPsPsPtE X +HIPK2 HIPK2 Q9H2X6 human TLE1 7088 Q04724 TLE1 human S289 24987529 DAsssPAstAsSASS X +HIPK2 HIPK2 Q9H2X6 human SIAH2 6478 O43255 SIAH2 human T119 26371004 PTCRGALtPSIRNLA X +HIPK2 HIPK2 Q9H2X6 human MECP2 4204 P51608 MECP2 human S216 18012096 VkRVLEKsPGkLLVk X X +HIPK2 HIPK2 Q9H2X6 human MECP2 4204 P51608 MECP2 human S80 452713 AVPEAsAsPKQRRsI X +HIPK2 HIPK2 Q9H2X6 human p53 7157 P04637 TP53 human S46 447536 AMDDLMLsPDDIEQW TAD2 X X 2521 +HIPK2 HIPK2 Q9H2X6 human SIRT1 23411 Q96EB6 SIRT1 human S682 41401500 SDSGTCQsPSLEEPM X X +HIPK2 HIPK2 Q9H2X6 human AML1 861 Q01196 RUNX1 human S276 454401 VHPAtPIsPGRASGM X +HIPK2 HIPK2 Q9H2X6 human PML 5371 P29590 PML human S8 470923 MEPAPARsPRPQQDP X +HIPK2 HIPK2 Q9H2X6 human p300 2033 Q09472 EP300 human S2279 486262 PVQPNPMsPQQHMLP X +HIPK2 HIPK2 Q9H2X6 human HIPK2 28996 Q9H2X6 HIPK2 human T880 29668000 QTIVIPDtPsPTVSV X X +HIPK2 HIPK2 Q9H2X6 human CBX4 8535 O00257 CBX4 human T497 470079 SLQVkPEtPASAAVA X +HIPK2 HIPK2 Q9H2X6 human HIPK2 28996 Q9H2X6 HIPK2 human Y361 449571 SkAVCstyLQsRYyR Pkinase X +HIPK2 HIPK2 Q9H2X6 human KLF3 51274 P57682 KLF3 human S108 4728775 sPPIKKysPPsPGVQ X +HIPK2 HIPK2 Q9H2X6 human KLF3 51274 P57682 KLF3 human S101 3193282 GLsMPsssPPIKKys X +HIPK2 HIPK2 Q9H2X6 human TLE1 7088 Q04724 TLE1 human S286 5707650 LKkDAsssPAstAsS X +HIPK2 HIPK2 Q9H2X6 human PDX1 18609 P52946 Pdx1 mouse S211 15103411 KEEDKKRsSGtPSGG X +HIPK2 HIPK2 Q9H2X6 human C/EBP-beta 1051 P17676 CEBPB human S76 456166 HERAIDFsPyLEPLG X X +HIPK2 HIPK2 Q9H2X6 human ZBTB4 57659 Q9P1Z0 ZBTB4 human T983 9184305 AAPPAPPtPPPPTLP X +HIPK2 HIPK2 Q9H2X6 human HMGA1 3159 P17096 HMGA1 human S36 455950 PRkQPPVsPGtALVG X +HIPK2 HIPK2 Q9H2X6 human SIRT1 23411 Q96EB6 SIRT1 human S27 452898 ADREAAssPAGEPLR X 2327 +HIPK2 HIPK2 Q9H2X6 human HIPK2 28996 Q9H2X6 HIPK2 human S364 4783726 VCstyLQsRYyRAPE Pkinase X +HIPK2 HIPK2 Q9H2X6 human HDAC3 8841 O15379 HDAC3 human S374 1874020216 KMLNHAPsVQIHDVP X +HIPK2 HIPK2 Q9H2X6 human p63 8626 Q9H3D4 TP63 human T491 4668106 PQQRNALtPTTIPDG X X +HIPK2 HIPK2 Q9H2X6 human HIPK2 15258 Q9QZR5 Hipk2 mouse Y361 449571 SKAVCStyLQsRYYR Pkinase X +HIPK2 HIPK2 Q9H2X6 human HIPK2 28996 Q9H2X6 HIPK2 human S924 25740749 SCVTVHDsPYSDSSS X +HIPK2 HIPK2 Q9H2X6 human AML1 861 Q01196 RUNX1 human S249 454399 DTRQIQPsPPWsyDQ X 4327 +HIPK2 HIPK2 Q9H2X6 human TLE1 7088 Q04724 TLE1 human S239 454385 KDSsHYDsDGDKsDD X +HIPK2 HIPK2 Q9H2X6 human KLF3 51274 P57682 KLF3 human S250 4728795 KRPLPVEsPDtQRKR X X +HIPK2 HIPK2 Q9H2X6 human Notch 1 4851 P46531 NOTCH1 human T2511 483083 VPEHPFLtPsPEsPD X +HIPK2 HIPK2 Q9H2X6 human SIAH2 6478 O43255 SIAH2 human T26 5393503 PPPQPQHtPsPAAPP X +HIPK2 HIPK2 Q9H2X6 human CTBP2 1488 P56545 CTBP2 human S428 3198539 AHPSQAPsPNQPTKH X X +HIPK2 HIPK2 Q9H2X6 human HMGA1 iso2 3159 P17096-2 HMGA1 human T67 451516 kTRkTTTtPGRkPrG X +HIPK2 HIPK2 Q9H2X6 human HIPK2 28996 Q9H2X6 HIPK2 human S848 29668002 RCAMVHSsPACSTSV X +HIPK2 HIPK2 Q9H2X6 human PPM1D 8493 O15297 PPM1D human S85 28847901 PLPDAGAsPAPsRCC PP2C X X +HIPK2 HIPK2 Q9H2X6 human AML1 861 Q01196 RUNX1 human T273 454403 sPsVHPAtPIsPGRA X +HIPK2 HIPK2 Q9H2X6 human HIPK2 28996 Q9H2X6 HIPK2 human S934 25740745 SDSSSNTsPYSVQQR X +HIPK2 HIPK2 Q9H2X6 human PDX1 18609 P52946 Pdx1 mouse S269 11279404 LPsGLSVsPQPSSIA X X +HIPK2 HIPK2 Q9H2X6 human KLF3 51274 P57682 KLF3 human S224 4728790 PPLMNsVsPPQALLQ X +HIPK2 HIPK2 Q9H2X6 human KLF3 51274 P57682 KLF3 human S111 4728780 IKKysPPsPGVQPFG X +HIPK2 HIPK2 Q9H2X6 human HMGA1 3159 P17096 HMGA1 human T53 451515 kEPsEVPtPkRPrGr X +HIPK2 HIPK2 Q9H2X6 human KLF3 51274 P57682 KLF3 human S71 4728750 LTVNKRSsPPsAGNs X +HIPK2 HIPK2 Q9H2X6 human PPM1D 8493 O15297 PPM1D human S54 28847900 QPLPPRPsPAALPGG X +HIPK2 HIPK2 Q9H2X6 human HIPK2 28996 Q9H2X6 HIPK2 human S668 27732212 GFQGLQAsPSkHAGY X +HIPK2 HIPK2 Q9H2X6 human p27Kip1 1027 P46527 CDKN1B human S10 447874 NVRVSNGsPsLErMD X X +HIPK2 HIPK2 Q9H2X6 human HIPK2 28996 Q9H2X6 HIPK2 human S882 29668001 IVIPDtPsPTVSVIT X X +HIPK2 HIPK2 Q9H2X6 human ZBTB4 57659 Q9P1Z0 ZBTB4 human T795 9184304 AAERPGGtPtPVIAY X +HIPK2 HIPK2 Q9H2X6 human ELF4 2000 Q99607 ELF4 human S369 1867984201 ASLELGPsLDEEIPT X +HIPK2 HIPK2 Q9H2X6 human CREB 1385 P16220 CREB1 human S257 14159739 PGVVMAssPALPTQP X X +HIPK2 HIPK2 Q9H2X6 human KLF3 51274 P57682 KLF3 human S92 3193285 PSSHRRAsPGLsMPs X +HIPK2 HIPK2 Q9H2X6 human PML 5371 P29590 PML human S38 451470 EGRQPsPsPsPtERA X X +HIPK2 HIPK2 Q9H2X6 human HMGA1 iso2 3159 P17096-2 HMGA1 human T42 451515 kEPsEVPtPkrPrGr X +HIPK2 HIPK2 Q9H2X6 human PDX1 18609 P52946 Pdx1 mouse T214 15103412 DKKRsSGtPSGGGGG X +HIPK2 HIPK2 Q9H2X6 human SIAH2 6478 O43255 SIAH2 human S28 471339 PQPQHtPsPAAPPAA X X +HIPK2 HIPK2 Q9H2X6 human C/EBP-beta 1051 P17676 CEBPB human T235 447878 SsssPPGtPSPADAK X X 3084 +HIPK2 HIPK2 Q9H2X6 human KLF3 51274 P57682 KLF3 human S216 4728785 DYYPEEMsPPLMNsV X +HIPK2 HIPK2 Q9H2X6 human spastin 6683 Q9UBP0 SPAST human S268 1211782 sGHHRAPsySGLSMV X X +Sik2 QIK Q3LRT3 rat QIK 315649 Q3LRT3 Sik2 rat S179 2560901 LLAtWCGsPPYAAPE Pkinase X +Pim1 Pim1 P26794 rat SKP2 6502 Q13309 SKP2 human T417 15165300 WGIkCRLtLQkPSCL X +Pim1 Pim1 P26794 rat SKP2 6502 Q13309 SKP2 human S64 457412 sNLGHPEsPPRkRLk X 14865 +Pim1 Pim1 P26794 rat SKP2 6502 Q13309 SKP2 human S72 480507 PPRkRLkskGsDkDF X +TAOK2 TAO2 Q9UL54 human RhoE 390 P61587 RND3 human S210 27933600 KNVKRNKsQRATKRI X X +TAOK2 TAO2 Q9UL54 human RhoE 390 P61587 RND3 human S218 25307985 QRATKRIsHMPsRPE X +TAOK2 TAO2 Q9UL54 human SEPT7 235072 O55131 Septin7 mouse T425 476328 EQQnssRtLEKNKKK X +TAOK2 TAO2 Q9UL54 human TAO2 9344 Q9UL54 TAOK2 human S181 7447419 SIMAPANsFVGtPYW Pkinase X +TAOK2 TAO2 Q9UL54 human RhoE 390 P61587 RND3 human S240 27933601 LRKDKAKsCTVM___ X +TAOK2 TAO2 Q9UL54 human SEPT7 989 Q16181 SEPTIN7 human T426 476328 EQQNssrtLEKNKKK X +Fgfr1 FGFR1 Q63827 rat FGFR1 79114 Q63827 Fgfr1 rat Y683 478646 LSMPLDQySPSFPDT X +Fgfr1 FGFR1 Q63827 rat FGFR1 79114 Q63827 Fgfr1 rat Y560 447918 RDIHHIDyyKKTTNG PK_Tyr_Ser-Thr X 3471; 3476; 52928 +Fgfr1 FGFR1 Q63827 rat FGFR1 79114 Q63827 Fgfr1 rat Y584 447920 EALFDRIyTHQSDVW PK_Tyr_Ser-Thr X +Fgfr1 FGFR1 Q63827 rat FGFR1 79114 Q63827 Fgfr1 rat Y673 447922 ALTSNQEyLDLSMPL X 84309 +Fgfr1 FGFR1 Q63827 rat FGFR1 79114 Q63827 Fgfr1 rat Y561 447919 DIHHIDyyKKTTNGR PK_Tyr_Ser-Thr X 3471; 3476; 52928 +Fgfr1 FGFR1 Q63827 rat FGFR1 79114 Q63827 Fgfr1 rat Y637 448642 SNCTNELyMMMRDCW PK_Tyr_Ser-Thr X +Fgfr1 FGFR1 Q63827 rat FGFR1 79114 Q63827 Fgfr1 rat Y608 447921 FTLGGSPyPGVPVEE PK_Tyr_Ser-Thr X +Fgr FGR P14234 mouse SDHA 66945 Q8K2B3 Sdha mouse Y604 1458603 YkVRVDEyDYSkPIQ Succ_DH_flav_C X X +Mapk12 P38G O08911 mouse MyoD 4654 P15172 MYOD1 human S201 40684505 SGDSDAssPRsNCsD Myf5 X +Mapk12 P38G O08911 mouse GYS1 2997 P13807 GYS1 human T84 1875332200 VELLEAPtPALkRTL Glycogen_syn X +Mapk12 P38G O08911 mouse GYS1 2997 P13807 GYS1 human S723 4787599 sssLStPsEPLsPts X +Mapk12 P38G O08911 mouse MyoD 4654 P15172 MYOD1 human S200 452000 YSGDSDAssPRsNCs Myf5 X +Mapk12 P38G O08911 mouse PFKFB3 170768 Q9ESY2 Pfkfb3 mouse S467 468406 NsVtPLAsPEPTKKP X X +Mapk12 P38G O08911 mouse GYS1 2997 P13807 GYS1 human S727 457615 StPsEPLsPtssLGE X +Mapk12 P38G O08911 mouse GYS1 2997 P13807 GYS1 human T721 457616 AtsssLStPsEPLsP X +Mapk12 P38G O08911 mouse GYS1 2997 P13807 GYS1 human T278 1875332700 kRkPDIVtPNGLNVk Glycogen_syn X +Epha8 EphA8 O09127 mouse EphA8 13842 O09127 Epha8 mouse Y838 448559 LAYGERPyWNMTNQD PK_Tyr_Ser-Thr X +Epha8 EphA8 O09127 mouse EphA8 13842 O09127 Epha8 mouse Y615 448558 FSAEPHTyEEPGRAG EphA2_TM X +Ntrk2 TrkB P15209 mouse TIAM1 21844 Q60610 Tiam1 mouse Y829 465610 PQPEEDIyELLYKEI RBD X +Ntrk2 TrkB P15209 mouse TrkB 18212 P15209 Ntrk2 mouse Y515 448813 PVIENPQyFGITNSQ X 4619 +MTOR mTOR P42345 human ULK1 22241 O70405 Ulk1 mouse S757 483139 PVVFtVGsPPsGAtP X 14202; 6888; 29313 +MTOR mTOR P42345 human ANKRD17 26057 O75179 ANKRD17 human S2047 484760 VssPssPsPPAQPGG X +MTOR mTOR P42345 human IRS1 3667 P35568 IRS1 human S636 447506 sGDyMPMsPKsVSAP X 2388 +MTOR mTOR P42345 human RRAGC 64121 Q9HB90 RRAGC human S21 14579528 GsYGAADsFPKDFGY X X +MTOR mTOR P42345 human Mnk2 2872 Q9HBH9 MKNK2 human S74 456328 KRGRAtDsFsGRFED X X +MTOR mTOR P42345 human TFE3 209446 Q64092 Tfe3 mouse S320 53350801 PAITVSNsCPAELPN X +MTOR mTOR P42345 human ULK1 8408 O75385 ULK1 human S758 483139 PVVFtVGsPPsGStP X 14202; 6888; 29313 +MTOR mTOR P42345 human BRD9 65980 Q9H8M2 BRD9 human S588 7231552 DPYEFLQsPEPAAsA X +MTOR mTOR P42345 human IGF2BP1 140486 O88477 Igf2bp1 mouse S181 453893 RGQPRQGsPVAAGAP X +MTOR mTOR P42345 human WASHC2A 387680 Q641Q2 WASHC2A human S700 20621635 DDVDSGGsLFGsPPT X +MTOR mTOR P42345 human ER-alpha 2099 P03372 ESR1 human S104 448099 FPPLNsVsPsPLMLL Oest_recep X X +MTOR mTOR P42345 human UVRAG 7405 Q9P2Y5 UVRAG human S549 7447343 RKItsLSssLDTsLD X +MTOR mTOR P42345 human TFEB 7942 P19484 TFEB human S122 3181616 PkPPPAAsPGVRAGH MITF_TFEB_C_3_N X 86843; 87932 +MTOR mTOR P42345 human SRm160 10250 Q8IYB3 SRRM1 human T574 453188 PRRRRtPtPPPRRRt X +MTOR mTOR P42345 human LPIN1 14245 Q91ZP3 Lpin1 mouse S472 471355 GARsANQsPQsVGGs X +MTOR mTOR P42345 human SENP3 26168 Q9H4L4 SENP3 human S143 36438203 LLYsKstsLtFHWKL X X +MTOR mTOR P42345 human SENP3 26168 Q9H4L4 SENP3 human T145 36438202 YsKstsLtFHWKLWG X X +MTOR mTOR P42345 human mTOR 2475 P42345 MTOR human S2448 447578 RsRtRtDsysAGQsV X 2971; 2976; 5536; 54932 +MTOR mTOR P42345 human mTOR 56717 Q9JLN9 Mtor mouse S2481 447498 tVPEsIHsFIGDGLV X 2974 +MTOR mTOR P42345 human DAP 1611 P51397 DAP human S51 471098 DQEWEsPsPPkPtVF DAP X +MTOR mTOR P42345 human SENP3 26168 Q9H4L4 SENP3 human S25 4172600 PGIPPAyssPRRERL X X +MTOR mTOR P42345 human PKN2 5586 Q16513 PKN2 human T958 2509079 TsEAPILtPPREPRI Pkinase_C X X +MTOR mTOR P42345 human p70S6K 6198 P23443 RPS6KB1 human T412 448607 NQVFLGFtyVAPsVL Pkinase_C X X 9206; 9234; 9205; 9209; 97596 +MTOR mTOR P42345 human MCL1 4170 Q07820 MCL1 human S64 479431 IGGSAGAsPPStLtP X X 13297 +MTOR mTOR P42345 human Akt1 207 P31749 AKT1 human S473 447855 RPHFPQFsysAsGtA Pkinase_C X X 9271; 3787; 4060; 4051; 5102; 4058; 2336; 2337; 4075; 4070; 5012; 4071; 92982; 5315; 9563; 9018; 12694; 52240; 11962; 15116; 88106; 26580; 68035; 31957; 23430; 20235 +MTOR mTOR P42345 human NRBF2 29982 Q96F24 NRBF2 human S120 476484 sPLsQkYsPSTEKCL NRBF2 X X +MTOR mTOR P42345 human SRm160 10250 Q8IYB3 SRRM1 human T572 453187 PPPRRRRtPtPPPRR X +MTOR mTOR P42345 human IKBKAP 8518 O95163 ELP1 human S1174 3178326 SETSsVVsGSEMSGK X +MTOR mTOR P42345 human p70S6K 83840 P67999 Rps6kb1 rat T412 448607 NQVFLGFtYVAPSVL Pkinase_C X 9206; 9234; 9205; 97596 +MTOR mTOR P42345 human NAA10 8260 P41227 NAA10 human S228 3190219 StDVKDssEAsDSAS X X +MTOR mTOR P42345 human TFEB 7942 P19484 TFEB human S211 25529700 LVGVTSSsCPADLTQ X 37681 +MTOR mTOR P42345 human PARK2 5071 O60260 PRKN human S127 1876336800 AVILHTDsRkDsPPA X X +MTOR mTOR P42345 human AR 367 P10275 AR human S96 448416 QQQGEDGsPQAHRRG Androgen_recep X X +MTOR mTOR P42345 human IRS1 25467 P35570 Irs1 rat S635 447507 yMPMsPKsVsAPQQI X 2388 +MTOR mTOR P42345 human mTOR 2475 P42345 MTOR human S2478 458290 tGttVPEsIHsFIGD X +MTOR mTOR P42345 human PASK 23178 Q96RG2 PASK human T640 1872667500 MAGLSFGtPtLDEPW X +MTOR mTOR P42345 human PRAS40 84335 Q96B36 AKT1S1 human S183 482839 PTQQYAKsLPVSVPV PRAS X X 5936 +MTOR mTOR P42345 human IRS1 16367 P35569 Irs1 mouse S302 450190 TRRSRtEsITAtsPA X 2384; 2491 +MTOR mTOR P42345 human LARP6 55323 Q9BRS8 LARP6 human S409 10942100 GRLNCStsPEIFRKC X +MTOR mTOR P42345 human SRm300 23524 Q9UQ35 SRRM2 human S1318 470844 sPEHKELsNsPLREN X +MTOR mTOR P42345 human IRS1 16367 P35569 Irs1 mouse S635 447507 yMPMsPKsVsAPQQI X 2388 +MTOR mTOR P42345 human SLC4A4 54403 O88343 Slc4a4 mouse S245 2047937 FSNPDNGsPAMtHRN Band_3_cyto X +MTOR mTOR P42345 human UNK 85451 Q9C0B0 UNK human S611 1880742152 GtsAsHGsLGLNGMN X X +MTOR mTOR P42345 human UVRAG 7405 Q9P2Y5 UVRAG human S498 1222327 GFsGGIPsPDKGHRK X X +MTOR mTOR P42345 human DNMT1 1786 P26358 DNMT1 human S714 452655 DNIPEMPsPkKMHQG X +MTOR mTOR P42345 human ULK1 8408 O75385 ULK1 human S638 3176158 FDFPKtPssQNLLAL X 14205 +MTOR mTOR P42345 human Sin1 79109 Q9BPZ7 MAPKAP1 human S260 28758701 PIHKFGFsTLALVEK CRIM X +MTOR mTOR P42345 human p70S6K 72508 Q8BSK8 Rps6kb1 mouse T412 448607 NQVFLGFtYVAPSVL Pkinase_C X X 9206; 9234; 9205; 97596 +MTOR mTOR P42345 human UNK 85451 Q9C0B0 UNK human S606 1880742148 ENTFLGtsAsHGsLG X +MTOR mTOR P42345 human LPIN1 14245 Q91ZP3 Lpin1 mouse S106 471342 IPMYLATsPILsEGA Lipin_N X +MTOR mTOR P42345 human HOXB13 10481 Q92826 HOXB13 human S31 1883583910 GRNLVAHsPLTSHPA X +MTOR mTOR P42345 human Akt1 207 P31749 AKT1 human T450 447857 tAQMItItPPDQDDs Pkinase_C X 9267; 12178 +MTOR mTOR P42345 human RRM1 6240 P23921 RRM1 human S631 41454201 IYTRRVLsGEFQIVN Ribonuc_red_lgC X X +MTOR mTOR P42345 human GRB10 2887 Q13322 GRB10 human S476 455870 MNILGsQsPLHPSTL X 11817 +MTOR mTOR P42345 human DUSP10 11221 Q9Y6W6 DUSP10 human S224 38520204 SCREGKDsFKRIFsK Rhodanese X +MTOR mTOR P42345 human WASHC2A 387680 Q641Q2 WASHC2A human S704 20621638 SGGsLFGsPPTSVPP X +MTOR mTOR P42345 human PKCE 5581 Q02156 PRKCE human T710 450184 TREEPVLtLVDEAIV Pkinase_C X +MTOR mTOR P42345 human STK11IP 114790 Q8N1F8 STK11IP human S404 4716927 EPRTLNPsPAGWFVQ X X +MTOR mTOR P42345 human LARP 23367 Q6PKG0 LARP1 human S774 453830 LPttVPEsPNyRNtR X +MTOR mTOR P42345 human FBXW8 231672 Q8BIA4 Fbxw8 mouse S86 4751099 DTSSRsRsPPDRDAt X X +MTOR mTOR P42345 human UNK 85451 Q9C0B0 UNK human S336 1880742106 QPSsAVssPtQPGPV X +MTOR mTOR P42345 human UNK 85451 Q9C0B0 UNK human S608 1880742150 TFLGtsAsHGsLGLN X +MTOR mTOR P42345 human MAF1 84232 Q9H063 MAF1 human S60 3211917 PHVLEALsPPQtsGL Maf1 X X +MTOR mTOR P42345 human AMOTL2 51421 Q9Y2J4 AMOTL2 human S759 477928 SsSQRAAsLDsVATS X X +MTOR mTOR P42345 human 4E-BP1 1978 Q13541 EIF4EBP1 human S44 3195716 tPGGtLFsttPGGtR eIF_4EBP X +MTOR mTOR P42345 human PASK 23178 Q96RG2 PASK human S953 1872667503 FLAsLPGstHsTAAE X +MTOR mTOR P42345 human UVRAG 7405 Q9P2Y5 UVRAG human S582 37039801 GHANVHPsQEQGEAL X +MTOR mTOR P42345 human SENP3 26168 Q9H4L4 SENP3 human S141 36438201 RMLLYsKstsLtFHW X X +MTOR mTOR P42345 human mTOR 2475 P42345 MTOR human T2473 458288 PAHKKtGttVPEsIH X +MTOR mTOR P42345 human N-Myc 4613 P04198 MYCN human S62 448222 LLPtPPLsPsrGFAE Myc_N X +MTOR mTOR P42345 human IRS1 16367 P35569 Irs1 mouse S632 447506 NGDyMPMsPKsVsAP X 2388 +MTOR mTOR P42345 human GRB10 14783 Q60760 Grb10 mouse S501 4727990 TRMNILSsQsPLHPS X +MTOR mTOR P42345 human Raptor 57521 Q8N122 RPTOR human S859 2024885 DtssLtQsAPAsPtN X X +MTOR mTOR P42345 human 4E-BP1 1978 Q13541 EIF4EBP1 human S65 447527 FLMECrNsPVtktPP eIF_4EBP X X 9451; 9456; 13443 +MTOR mTOR P42345 human NDRG1 10397 Q92597 NDRG1 human T346 454245 GtRsRsHtsEGtRsR X 3217; 5482; 6992; 7497; 8947; 89166 +MTOR mTOR P42345 human SOD1 6647 P00441 SOD1 human T40 1100571300 WGsIkGLtEGLHGFH Sod_Cu X +MTOR mTOR P42345 human IRS1 25467 P35570 Irs1 rat S632 447506 NGDyMPMsPKsVsAP X 2388 +MTOR mTOR P42345 human PKCB 5579 P05771 PRKCB human T642 447897 TRQPVELtPtDKLFI Pkinase_C X +MTOR mTOR P42345 human EEF2K 29904 O00418 EEF2K human S72 3150896 ksERysssGsPANsF X +MTOR mTOR P42345 human SRm300 23524 Q9UQ35 SRRM2 human S1329 459983 LRENsFGsPLEFRNs X +MTOR mTOR P42345 human mTOR 2475 P42345 MTOR human S2454 4780698 DsysAGQsVEILDGV X +MTOR mTOR P42345 human mTOR 2475 P42345 MTOR human S2481 447498 tVPEsIHsFIGDGLV X X 2974 +MTOR mTOR P42345 human ELL 8178 P55199 ELL human S309 3192127 LGDPAAssPPGERGR X +MTOR mTOR P42345 human 4E-BP1 13685 Q60876 Eif4ebp1 mouse T36 447497 PPGDysttPGGtLFs eIF_4EBP X 2855; 9459; 2846; 4923; 5123; 3929; 7547; 45613; 39788 +MTOR mTOR P42345 human EEF2K 29904 O00418 EEF2K human S74 3150899 ERysssGsPANsFHF X +MTOR mTOR P42345 human ER-alpha 2099 P03372 ESR1 human S118 448101 LHPPPQLsPFLQPHG Oest_recep X 2511 +MTOR mTOR P42345 human TORC2 74343 Q3U182 Crtc2 mouse S136 454632 PySPAYLsPPPEsGW X X +MTOR mTOR P42345 human DEPTOR 64798 Q8TB45 DEPTOR human T295 4723863 GyFsssPtLsssPPV X +MTOR mTOR P42345 human p70S6K 6198 P23443 RPS6KB1 human S394 448806 TRQtPVDsPDDStLS Pkinase_C X X 9208 +MTOR mTOR P42345 human PASK 23178 Q96RG2 PASK human S956 1872667502 sLPGstHsTAAELTG X +MTOR mTOR P42345 human ER-alpha 2099 P03372 ESR1 human S106 448100 PLNsVsPsPLMLLHP Oest_recep X X +MTOR mTOR P42345 human ATG13 51897 Q91YI1 Atg13 mouse S258 53377100 CTTSFSTsPPSQLSS X X +MTOR mTOR P42345 human SENP3 26168 Q9H4L4 SENP3 human S26 4957737 GIPPAyssPRRERLR X X +MTOR mTOR P42345 human SQSTM1 18412 Q64337 Sqstm1 mouse S351 14580829 SsKEVDPsTGELQsL X X 95697; 16177; 12074 +MTOR mTOR P42345 human DEPTOR 64798 Q8TB45 DEPTOR human S293 3897131 ssGyFsssPtLsssP X X +MTOR mTOR P42345 human SENP3 26168 Q9H4L4 SENP3 human S139 36438204 AFRMLLYsKstsLtF X X +MTOR mTOR P42345 human HOXB13 10481 Q92826 HOXB13 human T41 1883583908 TSHPAAPtLMPAVNY X +MTOR mTOR P42345 human BAG3 9531 O95817 BAG3 human T285 467534 GsPARsstPLHsPsP X +MTOR mTOR P42345 human RPRD1B 58490 Q9NQG5 RPRD1B human S166 452984 DDyPGsysPQDPsAG X +MTOR mTOR P42345 human SLC7A11 23657 Q9UPY5 SLC7A11 human S26 470841 NVNGRLPsLGNkEPP X X +MTOR mTOR P42345 human PASK 23178 Q96RG2 PASK human T642 1872667501 GLSFGtPtLDEPWLG X +MTOR mTOR P42345 human 4E-BP1 1978 Q13541 EIF4EBP1 human T70 447528 rNsPVtktPPRDLPt eIF_4EBP X X 9455; 13396 +MTOR mTOR P42345 human PKCE 5581 Q02156 PRKCE human S729 448789 QEEFKGFsYFGEDLM Pkinase_C X 9371 +MTOR mTOR P42345 human SRm300 23524 Q9UQ35 SRRM2 human S1326 453289 NsPLRENsFGsPLEF X +MTOR mTOR P42345 human UNK 85451 Q9C0B0 UNK human S255 41455256 RKHKYRSsPCPNVKH X +MTOR mTOR P42345 human PATL1 219988 Q86TB9 PATL1 human S179 453577 ALPRRstsPIIGsPP X +MTOR mTOR P42345 human SGK1 20393 Q9WVC6 Sgk1 mouse S422 448429 AEAFLGFsYAPPVDS Pkinase_C X +MTOR mTOR P42345 human RRAGC 64121 Q9HB90 RRAGC human T394 6732849 kALTHNGtPRNAI__ X +MTOR mTOR P42345 human GRB10 2887 Q13322 GRB10 human S428 455333 stPVRsVsENsLVAM BPS X +MTOR mTOR P42345 human UVRAG 7405 Q9P2Y5 UVRAG human S571 7447346 KGEDLVGsLNGGHAN X X +MTOR mTOR P42345 human SGK1 6446 O00141 SGK1 human S422 448429 AEAFLGFsYAPPTDS Pkinase_C X X +MTOR mTOR P42345 human APBA3 9546 O96018 APBA3 human S7 29668009 _MDFPtIsRsPsGPP X +MTOR mTOR P42345 human YAP1 10413 P46937 YAP1 human S436 1874499600 INQSTLPsQQNRFPD X X +MTOR mTOR P42345 human ZNRF2 223082 Q8NHG8 ZNRF2 human S145 4742836 GPRLVIGsLPAHLsP X X +MTOR mTOR P42345 human S6 6194 P62753 RPS6 human S236 448093 AKRRRLssLRAstsK X 5006; 4856; 4857; 4858; 4851; 4803; 2211; 3945; 3985; 5316; 4854; 8520; 48319; 40643; 9865; 38573; 14733; 27036; 34411; 62016; 62788; 81736; 97935; 99457; 15448 +MTOR mTOR P42345 human Raptor 57521 Q8N122 RPTOR human S863 453732 LtQsAPAsPtNkGVH X X +MTOR mTOR P42345 human NFAT3 73181 Q8K120 Nfatc4 mouse S170 448860 GGAFFsPsPGSSSLS X +MTOR mTOR P42345 human OSR1 9943 O95747 OXSR1 human S339 449248 EDGGWEWsDDEFDEE X +MTOR mTOR P42345 human ISCU 23479 Q9H1K1 ISCU human S14 469833 FRLRRAAsALLLRsP X X +MTOR mTOR P42345 human PATL1 219988 Q86TB9 PATL1 human S184 467884 stsPIIGsPPVRAVP X +MTOR mTOR P42345 human UVRAG 7405 Q9P2Y5 UVRAG human S550 4761506 KItsLSssLDTsLDF X X +MTOR mTOR P42345 human BAG3 9531 O95817 BAG3 human S289 469169 RsstPLHsPsPIRVH X +MTOR mTOR P42345 human DEPTOR 64798 Q8TB45 DEPTOR human S286 21697912 ssMssCGssGyFsss X +MTOR mTOR P42345 human LPIN1 14245 Q91ZP3 Lpin1 mouse S237 15502156 PSSDREWsPsPSSLV X +MTOR mTOR P42345 human IRS1 3667 P35568 IRS1 human S639 447507 yMPMsPKsVSAPQQI X 2388 +MTOR mTOR P42345 human 4E-BP1 1978 Q13541 EIF4EBP1 human T37 447497 PPGDysttPGGtLFs eIF_4EBP X X 2855; 9459; 2846; 5123; 3929; 7547; 45613; 39788 +MTOR mTOR P42345 human HSF1 3297 Q00613 HSF1 human S303 449045 RVkEEPPsPPQsPRV Vert_HS_TF X +MTOR mTOR P42345 human p70S6K 6198 P23443 RPS6KB1 human S434 448356 sFEPKIRsPRRFIGs X +MTOR mTOR P42345 human Myc 4609 P01106 MYC human S77 448586 LLPtPPLsPsRRsGL Myc_N X 13748 +MTOR mTOR P42345 human 4E-BP1 1978 Q13541 EIF4EBP1 human T41 449366 ysttPGGtLFsttPG eIF_4EBP X +MTOR mTOR P42345 human DUSP10 11221 Q9Y6W6 DUSP10 human S230 38520205 DsFKRIFsKEIIVyD Rhodanese X +MTOR mTOR P42345 human UVRAG 7405 Q9P2Y5 UVRAG human S522 471489 QyktPPPsyNSALAQ X +MTOR mTOR P42345 human PRAS40 84335 Q96B36 AKT1S1 human S221 2506802 DLDRIAAsMRALVLR PRAS X +MTOR mTOR P42345 human UVRAG 7405 Q9P2Y5 UVRAG human S508 7447337 KGHRKRAssENERLQ X +MTOR mTOR P42345 human UNK 85451 Q9C0B0 UNK human S359 1880742110 DSVPVsPssPHAPDL X +MTOR mTOR P42345 human GRB10 14783 Q60760 Grb10 mouse S503 455870 MNILSsQsPLHPSTL X 11817 +MTOR mTOR P42345 human DEPTOR 64798 Q8TB45 DEPTOR human S265 4723818 stsFMsVsPsKEIKI X +MTOR mTOR P42345 human PIP4K2C 79837 Q8TBX8 PIP4K2C human S328 34431500 LVGsYGTsPEGIGGY PIP5K X +MTOR mTOR P42345 human Akt1 11651 P31750 Akt1 mouse S473 447855 RPHFPQFsysAsGtA Pkinase_C X X 9271; 3787; 4060; 4051; 5102; 4058; 2336; 2337; 4075; 4070; 5012; 4071; 92982; 5315; 9563; 9018; 12694; 52240; 11962; 15116; 88106; 26580; 68035; 31957; 23430; 20235 +MTOR mTOR P42345 human AMBRA1 55626 Q9C0C7 AMBRA1 human S52 27443426 KRVELPDsPRSTFLL X X +MTOR mTOR P42345 human ANKRD17 26057 O75179 ANKRD17 human S2045 484761 yPVssPssPsPPAQP X +MTOR mTOR P42345 human HSF1 3297 Q00613 HSF1 human S326 455484 ssVDtLLsPTALIDs Vert_HS_TF X X +MTOR mTOR P42345 human UBR4 23352 Q5T4S7 UBR4 human S2932 20622176 GHPAGPGsVsSStGA X +MTOR mTOR P42345 human RUBCNL 80183 Q9H714 RUBCNL human S157 25284922 sPGILATsPYPETDS X X +MTOR mTOR P42345 human SCYL1 57410 Q96KG9 SCYL1 human S754 5208514 sTQPRPDsWGEDNWE X X +MTOR mTOR P42345 human p70S6K iso2 6198 P23443-2 RPS6KB1 human T389 448607 NQVFLGFtYVAPSVL Pkinase_C X X 9209; 97596 +MTOR mTOR P42345 human 4E-BP1 1978 Q13541 EIF4EBP1 human T46 447496 GGtLFsttPGGtRII eIF_4EBP X X 2855; 9459; 2846; 4923; 5123; 3929; 7547; 45613; 39788 +MTOR mTOR P42345 human ZNF768 79724 Q9H5H4 ZNF768 human S139 453883 sPGyEPRsPGyEsES RNA_pol_Rpb1_R X +MTOR mTOR P42345 human SENP3 26168 Q9H4L4 SENP3 human T142 36438200 MLLYsKstsLtFHWK X X +MTOR mTOR P42345 human LARP6 55323 Q9BRS8 LARP6 human S348 54436202 DPESNPTsPMAGRRH X +MTOR mTOR P42345 human S6 6194 P62753 RPS6 human S235 448092 IAKRRRLssLRAsts X 5006; 4856; 4857; 4858; 4851; 4803; 2211; 3945; 3985; 5316; 4854; 8520; 48319; 40643; 9865; 38573; 14733; 27036; 34411; 62016; 62788; 81736; 97935; 99457; 15448 +MTOR mTOR P42345 human NRBF2 29982 Q96F24 NRBF2 human S113 7446822 AEDAEGQsPLsQkYs NRBF2 X X +MTOR mTOR P42345 human MAF1 84232 Q9H063 MAF1 human S75 477954 sPsRLsksQGGEEEG Maf1 X +MTOR mTOR P42345 human NFAT3 73181 Q8K120 Nfatc4 mouse S168 448859 QGGGAFFsPsPGSSS X +MTOR mTOR P42345 human Akt1 11651 P31750 Akt1 mouse T308 447856 KDGAtMKtFCGtPEy Pkinase X X 5106; 2965; 9275; 4056; 5056; 13842; 13038; 43506; 48646; 86758; 80722; 77440; 80556 +MTOR mTOR P42345 human MAF1 84232 Q9H063 MAF1 human S68 3211920 PPQtsGLsPsRLsks Maf1 X X +MTOR mTOR P42345 human APBA3 9546 O96018 APBA3 human T5 29668010 ___MDFPtIsRsPsG X +MTOR mTOR P42345 human UVRAG 7405 Q9P2Y5 UVRAG human S493 7447334 GGADVGFsGGIPsPD X +MTOR mTOR P42345 human PASK 23178 Q96RG2 PASK human S949 14160727 RTRLFLAsLPGstHs X +MTOR mTOR P42345 human PIP4K2C 79837 Q8TBX8 PIP4K2C human S324 34431501 GPPALVGsYGTsPEG PIP5K X +MTOR mTOR P42345 human MST1 58231 Q9JI11 Stk4 mouse S438 4271929 GDyEFLKsWTVEDLQ Mst1_SARAH X +MTOR mTOR P42345 human GRB10 2887 Q13322 GRB10 human T155 22312200 PGsPPVLtPGsLPPS X +MTOR mTOR P42345 human DEPTOR 64798 Q8TB45 DEPTOR human S299 4723878 ssPtLsssPPVLCNP X X +MTOR mTOR P42345 human HOXB13 10481 Q92826 HOXB13 human T8 34606107 MEPGNYAtLDGAKDI X +MTOR mTOR P42345 human mTOR 2475 P42345 MTOR human T2474 458289 AHKKtGttVPEsIHs X +MTOR mTOR P42345 human WNK1 65125 Q9H4A3 WNK1 human S2032 469047 DGsGsPHsPHQLssK X +MTOR mTOR P42345 human LARP 23367 Q6PKG0 LARP1 human S766 483150 EPStIARsLPttVPE X +MTOR mTOR P42345 human PKCE 5581 Q02156 PRKCE human T566 448787 LNGVTTTtFCGTPDy Pkinase X 9379; 2060; 38938 +PRPF4B PRP4 Q13523 human ELK1 2002 P19419 ELK1 human T417 452139 ISVDGLstPVVLsPG X X +PIK3CA PIK3CA P42336 human SMAD2 Q1W668 SMAD2 cow S245 448794 NQSMDTGsPAELsPT X +PIK3CA PIK3CA P42336 human p70S6K 6198 P23443 RPS6KB1 human T412 448607 NQVFLGFtyVAPsVL Pkinase_C X 9206; 9234; 9205; 9209; 97596 +PIK3CA PIK3CA P42336 human SMAD2 Q1W668 SMAD2 cow T220 448793 QSNYIPEtPPPGYIS X +PIK3CA PIK3CA P42336 human PIK3R1 5295 P27986 PIK3R1 human S608 448133 ENtEDQysLVEDDED X X +PIK3CA PIK3CA P42336 human SMAD2 Q1W668 SMAD2 cow S255 448796 ELsPTTLsPVNHSLD X +PIK3CA PIK3CA P42336 human p70S6K 6198 P23443 RPS6KB1 human T252 448606 HDGtVtHtFCGtIEY Pkinase X +PIK3CA PIK3CA P42336 human TPM1 7168 P09493 TPM1 human S61 456510 EDELDkysEALKDAQ Tropomyosin X +PIK3CA PIK3CA P42336 human Akt1 11651 P31750 Akt1 mouse T308 447856 KDGAtMKtFCGtPEy Pkinase X 5106; 2965; 9275; 4056; 5056; 13842; 13038; 43506; 48646; 86758; 80722; 77440; 80556 +PIK3CA PIK3CA P42336 human Akt1 207 P31749 AKT1 human T308 447856 kDGAtMKtFCGtPEy Pkinase X 5106; 2965; 9275; 4056; 5056; 13842; 13038; 43506; 48646; 86758; 80722; 77440; 80556 +Gsk3b GSK3B P18266 rat CTNNB1 84353 Q9WU82 Ctnnb1 rat S45 447488 GATtTAPsLSGkGNP X 9565; 24710; 70034; 19807; 96727; 77605 +Gsk3b GSK3B P18266 rat MAP1B 17755 P14873 Map1b mouse T1265 455476 PPsPIEKtPLGERsV X +Gsk3b GSK3B P18266 rat CTNNB1 84353 Q9WU82 Ctnnb1 rat S33 447487 QQQSYLDsGIHsGAT X X 9561; 2009; 4270; 13537; 41334; 60180 +Gsk3b GSK3B P18266 rat eIF2B-epsilon 192234 Q64350 Eif2b5 rat S535 449905 VDPEELDsRAGsPQL X X +Gsk3b GSK3B P18266 rat Myc 4609 P01106 MYC human T73 448496 kkFELLPtPPLsPsR Myc_N X 46650 +Gsk3b GSK3B P18266 rat Doublecortin 84394 Q9ESI7 Dcx rat S332 451363 STPKSKQsPISTPTs X +Gsk3b GSK3B P18266 rat RCAN1 266766 Q6IN33 Rcan1 rat S108 456022 PDKQFLIsPPAsPPV Calcipressin X +Gsk3b GSK3B P18266 rat PXN 360820 Q66H76 Pxn rat S126 450227 SFPNKQKsAEPsPtV Paxillin X +Gsk3b GSK3B P18266 rat PSD-95 29495 P31016 Dlg4 rat T19 3609101 YRYQDEDtPPLEHSP X +Gsk3b GSK3B P18266 rat CRMP-2 25416 P47942 Dpysl2 rat T514 454386 SVtPKTVtPASsAKT X 9397 +Gsk3b GSK3B P18266 rat SIK 59329 Q9R1U5 Sik1 rat T182 456034 KPGEPLStWCGsPPY Pkinase X X +Gsk3b GSK3B P18266 rat CTNNB1 84353 Q9WU82 Ctnnb1 rat S37 447582 YLDsGIHsGATtTAP X 9561; 2009; 4270; 13537; 41334; 60180 +Gsk3b GSK3B P18266 rat ADD2 24171 Q05764 Add2 rat S598 3147633 EPGsPVKsTPAsPVQ X +Gsk3b GSK3B P18266 rat SIK 59329 Q9R1U5 Sik1 rat S186 2560900 PLStWCGsPPYAAPE Pkinase X +Gsk3b GSK3B P18266 rat CREB iso1 81646 P15337-1 Creb1 rat S129 450092 QKRREILsRRPsYRk pKID X +Gsk3b GSK3B P18266 rat MAP1B 17755 P14873 Map1b mouse S1260 454136 sLsPsPPsPIEKtPL X +Gsk3b GSK3B P18266 rat CRMP-2 25416 P47942 Dpysl2 rat S518 448081 KTVtPASsAKTsPAK X +Gsk3b GSK3B P18266 rat NFH 24587 P16884 Nefh rat S493 455548 GEEAATTsPPAEEAA X +Gsk3b GSK3B P18266 rat ADD2 24171 Q05764 Add2 rat S692 454590 sVTsGPLsPEGsPSK X +Gsk3b GSK3B P18266 rat CTNNB1 84353 Q9WU82 Ctnnb1 rat T41 447583 GIHsGATtTAPsLSG X 9561; 9565; 4270; 13537; 41334; 60180 +Gsk3b GSK3B P18266 rat gephyrin 64845 Q03555 Gphn rat S283 2020113 LSttPsEsPRAQAts X +NEK6 NEK6 Q9HC98 human KIF20A 10112 O95235 KIF20A human S754 114810408 ELQkLGEsLQsAERA X +NEK6 NEK6 Q9HC98 human SGK1 6446 O00141 SGK1 human S377 11507607 PPFNPNVsGPNDLRH Pkinase_C X +NEK6 NEK6 Q9HC98 human BSG iso2 682 P35613-2 BSG human S252 476131 GsAPLKSsGQHQNDK X +NEK6 NEK6 Q9HC98 human DDR1 780 Q08345 DDR1 human S788 11507611 KIADFGMsRNLyAGD PK_Tyr_Ser-Thr X +NEK6 NEK6 Q9HC98 human ACD 65057 Q96AP0 ACD human S169 15407290 sNAGLSLsQLLDEMR X +NEK6 NEK6 Q9HC98 human Rb-like 2 5934 Q08999 RBL2 human S659 11507610 DTGGLGRsItsPttL X +NEK6 NEK6 Q9HC98 human p70S6K 6198 P23443 RPS6KB1 human T412 448607 NQVFLGFtyVAPsVL Pkinase_C X 9206; 9234; 9205; 9209; 97596 +NEK6 NEK6 Q9HC98 human p70S6K 83840 P67999 Rps6kb1 rat T412 448607 NQVFLGFtYVAPSVL Pkinase_C X X 9206; 9234; 9205; 97596 +NEK6 NEK6 Q9HC98 human NUP98 iso2 4928 P52948-2 NUP98 human S591 470431 VLKNLNNsNLFsPVN X +NEK6 NEK6 Q9HC98 human EML4 27436 Q9HC35 EML4 human S144 465781 QsPQIRAsPsPQPss X X +NEK6 NEK6 Q9HC98 human KIF11 3832 P52732 KIF11 human S1033 20798600 GINtLERskVEETTE Microtub_bind X +NEK6 NEK6 Q9HC98 human STAT3 6774 P40763 STAT3 human S727 448191 NtIDLPMsPrTLDSL X X 9134; 9136; 34911; 94994; 49081; 58978; 87544; 71958; 50804 +NEK6 NEK6 Q9HC98 human STAT3 6774 P40763 STAT3 human Y705 448192 DPGsAAPyLktKFIC X 4093; 9145; 4324; 9131; 9138; 4323; 4074; 4113; 48313; 20977; 25023; 8119; 52075; 52527; 73533; 61958; 73452; 16185; 74309 +NEK6 NEK6 Q9HC98 human KIF20A 10112 O95235 KIF20A human S683 12667657 RsQRLAAsAstQQLQ X +NEK6 NEK6 Q9HC98 human NMDAR1 2902 Q05586 GRIN1 human S890 447737 ITSTLASsFKRRRss X 3381 +NEK6 NEK6 Q9HC98 human KIF20A 10112 O95235 KIF20A human S883 4712600 RRsPLLKsGPFGKKY X +NEK6 NEK6 Q9HC98 human p70S6K 6198 P23443 RPS6KB1 human S403 11507608 DDStLSEsANQVFLG Pkinase_C X +NEK6 NEK6 Q9HC98 human p70S6K 6198 P23443 RPS6KB1 human S53 11507609 EGGQLNEsMDHGGVG X +NEK6 NEK6 Q9HC98 human KIF20A 10112 O95235 KIF20A human S240 31855501 QEEELSTsLkRsVyI Kinesin X +NEK6 NEK6 Q9HC98 human SGK1 6446 O00141 SGK1 human S422 448429 AEAFLGFsYAPPTDS Pkinase_C X +NEK6 NEK6 Q9HC98 human PSMD2 5708 Q13200 PSMD2 human S361 487471 ENNrFGGsGsQVDsA X +NEK6 NEK6 Q9HC98 human CDK7 1022 P50613 CDK7 human S161 2192636 ADFGLAksFGsPNRA Pkinase X +NEK6 NEK6 Q9HC98 human KIF20A 10112 O95235 KIF20A human S244 459830 LSTsLkRsVyIEsRI Kinesin X +NEK6 NEK6 Q9HC98 human HSP70 3303 P0DMV8 HSPA1B human T66 31882985 VALNPQNtVFDAkRL HSP70 X X +NEK6 NEK6 Q9HC98 human ERCC2 2068 P18074 ERCC2 human T425 1878257800 IEPFDDRtPTIANPI X X +NEK6 NEK6 Q9HC98 human NUP98 iso2 4928 P52948-2 NUP98 human S822 3150833 TSRCLIKsPDRLADI Nucleoporin2 X +CSNK1A1 CK1A P48729 human SLC4A1 6521 P02730 SLC4A1 human S303 451406 IDAYMAQsRGELLHS Band_3_cyto X +CSNK1A1 CK1A P48729 human FOXG1 2290 P55316 FOXG1 human S19 482880 MIPKSSFsINSLVPE X X +CSNK1A1 CK1A P48729 human 14-3-3 theta 10971 P27348 YWHAQ human S232 456053 LTLWtsDsAGEECDA X X +CSNK1A1 CK1A P48729 human TDP-43 23435 Q13148 TARDBP human S379 3084615 NSYsGsNsGAAIGWG X +CSNK1A1 CK1A P48729 human FOXO4 4303 P98177 FOXO4 human S268 231166708 ssNAsSVsTRLsPLR X X +CSNK1A1 CK1A P48729 human TDP-43 23435 Q13148 TARDBP human S393 6855908 GsAsNAGsGsGFNGG X +CSNK1A1 CK1A P48729 human CARD11 84433 Q9BXL7 CARD11 human S615 5403700 RYSFGPSsIHSSSSS X +CSNK1A1 CK1A P48729 human ATF-1 466 P18846 ATF1 human S47 15725601 EsQDSSDsIGssQKA pKID X +CSNK1A1 CK1A P48729 human SLC18A2 25549 Q01827 Slc18a2 rat S514 465596 GDDEEsEsD______ X +CSNK1A1 CK1A P48729 human NFM P16053 NEFM chicken S471 22689704 sEMEDALsAIAEEMA X +CSNK1A1 CK1A P48729 human GJA1 24392 P08050 Gja1 rat S325 449992 NRMGQAGstIsNsHA Connexin43 X X +CSNK1A1 CK1A P48729 human SNCA 6622 P37840 SNCA human T64 1876998407 EktkEQVtNVGGAVV Synuclein X X +CSNK1A1 CK1A P48729 human HSP70 3303 P0DMV8 HSPA1B human T636 18010647 GGsGsGPtIEEVD__ X +CSNK1A1 CK1A P48729 human p53 7157 P04637 TP53 human S37 447532 NVLsPLPsQAMDDLM TAD2 X 9289 +CSNK1A1 CK1A P48729 human TDP-43 23435 Q13148 TARDBP human S387 6855913 GAAIGWGsAsNAGsG X +CSNK1A1 CK1A P48729 human DARPP-32 360616 Q6J4I0 Ppp1r1b rat S137 448046 EEDEEEDsQAEVLKG DARPP-32 X +CSNK1A1 CK1A P48729 human JADE1 79960 Q6IE81 JADE1 human S18 35530402 EDsDDNGsLsTTWSQ EPL1 X X +CSNK1A1 CK1A P48729 human BACE 23621 P56817 BACE1 human S498 450178 DDFADDIsLLk____ X +CSNK1A1 CK1A P48729 human CTPS2 56474 Q9NRF8 CTPS2 human S568 3213615 LsSsDrysDAsDDsF X X +CSNK1A1 CK1A P48729 human galectin-3 3958 P17931 LGALS3 human S12 451567 FsLHDALsGSGNPNP X +CSNK1A1 CK1A P48729 human CTNNB1 84353 Q9WU82 Ctnnb1 rat S45 447488 GATtTAPsLSGkGNP X 9565; 24710; 70034; 19807; 96727; 77605 +CSNK1A1 CK1A P48729 human TDP-43 23435 Q13148 TARDBP human T116 6855901 LGLPWkTtEQDLkEY RRM_1 X +CSNK1A1 CK1A P48729 human MALT1 10892 Q9UDY8 MALT1 human S573 1869465811 GTEYsAEsLVRNLQW Peptidase_C14 X +CSNK1A1 CK1A P48729 human BID 637 P55957 BID human S64 1880042000 LQtDGNRsSHsRLGR X +CSNK1A1 CK1A P48729 human ERG 2078 P11308 ERG human S38 50259802 TEMTASsssDyGQTs X +CSNK1A1 CK1A P48729 human APC 324 P25054 APC human S1507 452097 FsCsssLsALsLDEP APC_r X +CSNK1A1 CK1A P48729 human AGO2 27161 Q9UKV8 AGO2 human S831 7104887 sAEGsHtsGQsNGRD X X +CSNK1A1 CK1A P48729 human TBX21 57765 Q9JKD8 Tbx21 mouse S508 458229 PsSGDSSsPAGAPsP X +CSNK1A1 CK1A P48729 human CREB 1385 P16220 CREB1 human S142 451886 PRIEEEKsEEETSAP X +CSNK1A1 CK1A P48729 human HSP90B 3326 P08238 HSP90AB1 human S718 3177650 LEGDEDAsRMEEVD_ X +CSNK1A1 CK1A P48729 human CREM 12916 P27699 Crem mouse S113 450059 TIAEtDDsADsEVID pKID X +CSNK1A1 CK1A P48729 human VHL 7428 P40337 VHL human S72 469117 SVNsREPsQVIFCNr VHL X +CSNK1A1 CK1A P48729 human SQSTM1 8878 Q13501 SQSTM1 human S349 14580829 sskEVDPstGELQsL X X 95697; 16177; 12074 +CSNK1A1 CK1A P48729 human ATF-1 466 P18846 ATF1 human S36 465558 AQQVSSLsESEEsQD X +CSNK1A1 CK1A P48729 human SNCA 20617 O55042 Snca mouse T64 1876998407 EKtKEQVtNVGGAVV Synuclein X X +CSNK1A1 CK1A P48729 human GJC1 14615 P28229 Gjc1 mouse S382 22598807 KSGSNKssIssKsGD X +CSNK1A1 CK1A P48729 human ATM 472 Q13315 ATM human S1270 1881548600 SHFDEVksIANQIQE X X +CSNK1A1 CK1A P48729 human PHLPP 23239 O60346 PHLPP1 human S1379 22769302 GSKGLWDsLsVEEAV PP2C X +CSNK1A1 CK1A P48729 human IFNAR1 3454 P17181 IFNAR1 human S535 454418 SSQTsQDsGNysNED X +CSNK1A1 CK1A P48729 human p53 7157 P04637 TP53 human T18 447541 EPPLsQEtFsDLWkL P53_TAD X 2529 +CSNK1A1 CK1A P48729 human NLRP3 114548 Q96P20 NLRP3 human S806 1877558200 KLVELDLsDNALGDF LRR_6 X +CSNK1A1 CK1A P48729 human CREB 1385 P16220 CREB1 human S100 451809 EsEDsQEsVDsVtDs pKID X X +CSNK1A1 CK1A P48729 human CREM 12916 P27699 Crem mouse S121 450061 ADsEVIDsHKRREIL pKID X +CSNK1A1 CK1A P48729 human Myc 4609 P01106 MYC human S267 466014 PPTtssDsEEEQEDE Myc_N X +CSNK1A1 CK1A P48729 human CTNNB1 1499 P35222 CTNNB1 human S45 447488 GATtTAPsLsGkGNP X X 9565; 9564; 24710; 70034; 19807; 96727; 77605 +CSNK1A1 CK1A P48729 human NFM P16053 NEFM chicken S502 1868948300 AVEEEAVsEKAAEQA X +CSNK1A1 CK1A P48729 human SLC4A1 6521 P02730 SLC4A1 human T42 451405 AAHDtEAtAtDyHtt X +CSNK1A1 CK1A P48729 human p53 22059 P02340 Tp53 mouse S12 447538 EEsQsDIsLELPLsQ P53_TAD X +CSNK1A1 CK1A P48729 human RHOB 388 P62745 RHOB human S185 2853110 ALQkRYGsQNGCINC X X +CSNK1A1 CK1A P48729 human RBM21 64852 Q9H6E5 TUT1 human S6 31080908 __MAAVDsDVEsLPr X X +CSNK1A1 CK1A P48729 human ERG 2078 P11308 ERG human S39 50259800 EMTASsssDyGQTsK X +CSNK1A1 CK1A P48729 human TDP-43 23435 Q13148 TARDBP human T25 6855922 IPSEDDGtVLLSTVT TDP43_N X +CSNK1A1 CK1A P48729 human LRP6 4040 O75581 LRP6 human S1490 456289 AILNPPPsPAtERsH X 2568 +CSNK1A1 CK1A P48729 human 14-3-3 zeta 7534 P63104 YWHAZ human T232 449846 LTLWtsDtQGDEAEA X +CSNK1A1 CK1A P48729 human GJA1 2697 P17302 GJA1 human S325 449992 NRMGQAGstIsNsHA Connexin43 X +CSNK1A1 CK1A P48729 human DEPTOR 64798 Q8TB45 DEPTOR human T149 21697916 kLMsPENtLLQPREE DEP X +CSNK1A1 CK1A P48729 human TDP-43 23435 Q13148 TARDBP human S2 6855903 ______MsEyIRVtE X +CSNK1A1 CK1A P48729 human ZRANB1 54764 Q9UGI0 ZRANB1 human S209 23077543 RWRGsCssGNsQRRS X X +CSNK1A1 CK1A P48729 human TDP-43 23435 Q13148 TARDBP human S409 3084616 GssMDskssGWGM__ X +CSNK1A1 CK1A P48729 human GYS1 100008660 P13834 GYS1 rabbit S11 451605 SRTLsVSsLPGLEDW X +CSNK1A1 CK1A P48729 human EIF6 3692 P56537 EIF6 human S175 17535703 EDQDELssLLQVPLV eIF-6 X +CSNK1A1 CK1A P48729 human TDP-43 23435 Q13148 TARDBP human S242 6855910 ADDQIAQsLCGEDLI RRM_1 X +CSNK1A1 CK1A P48729 human AHCYL1 229709 Q80SW1 Ahcyl1 mouse S74 467246 IsQsstDsySsAAsy X +CSNK1A1 CK1A P48729 human PHLPP 23239 O60346 PHLPP1 human T1363 22769303 HVQsVLLtPQDEFFI PP2C X +CSNK1A1 CK1A P48729 human ERG 2078 P11308 ERG human S37 50259801 KTEMTASsssDyGQT X +CSNK1A1 CK1A P48729 human GJA1 2697 P17302 GJA1 human S328 449993 GQAGstIsNsHAQPF Connexin43 X +CSNK1A1 CK1A P48729 human CDC25A 993 P30304 CDC25A human S82 450248 GssEstDsGFCLDsP X X +CSNK1A1 CK1A P48729 human galectin-3 373917 A4GTP0 LGALS3 chicken S6 450131 __MSDGFsLsDALPA X +CSNK1A1 CK1A P48729 human AHCYL1 229709 Q80SW1 Ahcyl1 mouse S68 467244 RSLSRsIsQsstDsy X +CSNK1A1 CK1A P48729 human ECE1 1889 P42892 ECE1 human S36 3053606 EDLVDsLsEGDAyPN X +CSNK1A1 CK1A P48729 human TDP-43 23435 Q13148 TARDBP human S407 6855919 GFGssMDskssGWGM X +CSNK1A1 CK1A P48729 human APC 324 P25054 APC human S1510 999606 sssLsALsLDEPFIQ X +CSNK1A1 CK1A P48729 human GJA1 24392 P08050 Gja1 rat S330 449994 AGstIsNsHAQPFDF Connexin43 X X +CSNK1A1 CK1A P48729 human CTNND1 iso3 1500 O60716-3 CTNND1 human S268 450453 PQVRVGGssVDLHRF X +CSNK1A1 CK1A P48729 human TDP-43 23435 Q13148 TARDBP human S254 6855920 DLIIKGIsVHISNAE X +CSNK1A1 CK1A P48729 human OSBP2 23762 Q969R2 OSBP2 human S762 11171320 ECSKVMHssPssPsS Oxysterol_BP X +CSNK1A1 CK1A P48729 human FOXO1A 2308 Q12778 FOXO1 human S322 449112 PRtssNAstIsGRLs X +CSNK1A1 CK1A P48729 human SRPK2 6733 P78362 SRPK2 human S497 483632 SRtVsAsstGDLPkA X 23708; 96446 +CSNK1A1 CK1A P48729 human NFAT4 4775 Q12968 NFATC3 human T204 11507601 NEAAARFtLGsPLts X X +CSNK1A1 CK1A P48729 human NFAT5 10725 O94916 NFAT5 human S158 2715403 LLDNsRMsCQDEGCG X +CSNK1A1 CK1A P48729 human APC 324 P25054 APC human S1504 999604 PDGFsCsssLsALsL APC_r X +CSNK1A1 CK1A P48729 human p53 22059 P02340 Tp53 mouse S7 448716 _MTAMEEsQsDIsLE X +CSNK1A1 CK1A P48729 human hnRNP C1/C2 3183 P07910 HNRNPC human S260 448833 sEGGADDsAEEGDLL X X +CSNK1A1 CK1A P48729 human p53 22059 P02340 Tp53 mouse S9 447537 TAMEEsQsDIsLELP P53_TAD X 9285 +CSNK1A1 CK1A P48729 human OSBP2 23762 Q969R2 OSBP2 human S766 15721694 VMHssPssPsSDGKQ Oxysterol_BP X +CSNK1A1 CK1A P48729 human ECE1 1889 P42892 ECE1 human S34 3053605 DEEDLVDsLsEGDAy X +CSNK1A1 CK1A P48729 human TDP-43 23435 Q13148 TARDBP human S305 6855916 GLGNNQGsNMGGGMN X +CSNK1A1 CK1A P48729 human Myc 4609 P01106 MYC human S82 4967400 PLsPsRRsGLCsPSy Myc_N X +CSNK1A1 CK1A P48729 human BID 637 P55957 BID human S67 14570494 DGNRsSHsRLGRIEA BID X +CSNK1A1 CK1A P48729 human FOXO4 4303 P98177 FOXO4 human S265 231166707 PRSssNAsSVsTRLs X X +CSNK1A1 CK1A P48729 human SLC18A2 25549 Q01827 Slc18a2 rat S512 465595 PIGDDEEsEsD____ X +CSNK1A1 CK1A P48729 human RORA 6095 P35398 RORA human S100 1212279800 CKGFFRRsQQSNATY zf-C4 X X +CSNK1A1 CK1A P48729 human SNCA 6622 P37840 SNCA human S87 449948 ktVEGAGsIAAATGF Synuclein X +CSNK1A1 CK1A P48729 human ATF-1 466 P18846 ATF1 human S51 15725602 SSDsIGssQKAHGIL pKID X +CSNK1A1 CK1A P48729 human SNCA 6622 P37840 SNCA human S129 448278 NEAyEMPsEEGyQDy Synuclein X X 23706; 87281 +CSNK1A1 CK1A P48729 human TDP-43 23435 Q13148 TARDBP human T88 6855904 NKRkMDEtDAssAVk X +CSNK1A1 CK1A P48729 human GJC1 14615 P28229 Gjc1 mouse S393 22598810 KsGDGKTsVWI____ X +CSNK1A1 CK1A P48729 human GJA1 2697 P17302 GJA1 human S330 449994 AGstIsNsHAQPFDF Connexin43 X +CSNK1A1 CK1A P48729 human FAK iso5 396416 Q92063 PTK2 chicken S151 447963 DVRLsRGsIEREDGG X +CSNK1A1 CK1A P48729 human MDM4 4194 O15151 MDM4 human S289 456471 DDLEDSKsLSDDTDV X X +CSNK1A1 CK1A P48729 human calsenilin 30818 Q9Y2W7 KCNIP3 human S63 450214 APQGSDSsDSELELS X +CSNK1A1 CK1A P48729 human MCR 4306 P08235 NR3C2 human T800 1875398904 LPLEDQItLIQYSWM Hormone_recep X X +CSNK1A1 CK1A P48729 human TDP-43 23435 Q13148 TARDBP human S410 3084601 ssMDskssGWGM___ X +CSNK1A1 CK1A P48729 human RAPGEF2 9693 Q9Y4G8 RAPGEF2 human S1248 30995200 AADsGRGsWTSCSsG X X +CSNK1A1 CK1A P48729 human galectin-3 3958 P17931 LGALS3 human S6 450131 __MADNFsLHDALsG X X +CSNK1A1 CK1A P48729 human TIAM1 7074 Q13009 TIAM1 human S329 23152631 DVNAGEGsEFADsGI X +CSNK1A1 CK1A P48729 human NFAT4 4775 Q12968 NFATC3 human S211 11507600 tLGsPLtsPGGsPGG X X +CSNK1A1 CK1A P48729 human CTNND1 iso3 1500 O60716-3 CTNND1 human S269 470326 QVRVGGssVDLHRFH X +CSNK1A1 CK1A P48729 human TDP-43 23435 Q13148 TARDBP human S347 6855906 LAsQQNQsGPsGNNQ X +CSNK1A1 CK1A P48729 human CDH1 999 P12830 CDH1 human S844 478354 GsGsEAAsLSsLNsS CADH_Y-type_LIR X +CSNK1A1 CK1A P48729 human CREM 12916 P27699 Crem mouse S116 450060 EtDDsADsEVIDsHK pKID X +CSNK1A1 CK1A P48729 human CREB 1385 P16220 CREB1 human S97 451808 TIAEsEDsQEsVDsV X +CSNK1A1 CK1A P48729 human ZRANB1 54764 Q9UGI0 ZRANB1 human T35 50840530 RAQRPSGtIItEDPF X X +CSNK1A1 CK1A P48729 human AGO2 27161 Q9UKV8 AGO2 human S834 40509024 GsHtsGQsNGRDHQA X X +CSNK1A1 CK1A P48729 human TDP-43 23435 Q13148 TARDBP human S395 6855914 AsNAGsGsGFNGGFG X +CSNK1A1 CK1A P48729 human TDP-43 23435 Q13148 TARDBP human S273 6855912 SNRQLERsGrFGGNP X +CSNK1A1 CK1A P48729 human PARK2 5071 O60260 PRKN human S378 454424 AyHEGECsAVFEASG X +CSNK1A1 CK1A P48729 human LRP6 4040 O75581 LRP6 human T1493 466015 NPPPsPAtERsHytM X X +CSNK1A1 CK1A P48729 human CBX4 8535 O00257 CBX4 human T437 7315202 ARsIsTPtCLGGsPA X X +CSNK1A1 CK1A P48729 human FOXO1A 2308 Q12778 FOXO1 human S325 449114 ssNAstIsGRLsPIM X +CSNK1A1 CK1A P48729 human RAPGEF2 9693 Q9Y4G8 RAPGEF2 human S1244 30995201 ASLDAADsGRGsWTS X X +CSNK1A1 CK1A P48729 human AHCYL1 229709 Q80SW1 Ahcyl1 mouse S71 467245 SRsIsQsstDsySsA X +CSNK1A1 CK1A P48729 human TDP-43 23435 Q13148 TARDBP human S403 3084617 GFNGGFGssMDskss X +CSNK1A1 CK1A P48729 human FADD 8772 Q13158 FADD human S194 447653 QNRsGAMsPMsWNsD X 2781 +CSNK1A1 CK1A P48729 human MCR 4306 P08235 NR3C2 human S936 1875398906 DSMHDLVsDLLEFCF Hormone_recep X +CSNK1A1 CK1A P48729 human galectin-3 373917 A4GTP0 LGALS3 chicken S8 18575500 MSDGFsLsDALPAHN X +CSNK1A1 CK1A P48729 human BID 12122 P70444 Bid mouse S61 448404 DELQtDGsQAsRsFN BID X +CSNK1A1 CK1A P48729 human hnRNP C1/C2 3183 P07910 HNRNPC human S253 448835 EtNVkMEsEGGADDs X X +CSNK1A1 CK1A P48729 human DEPTOR 64798 Q8TB45 DEPTOR human S287 4723848 sMssCGssGyFsssP X X +CSNK1A1 CK1A P48729 human NFkB-p65 5970 Q04206 RELA human S316 31880654 FksIMkksPFsGPtD X +CSNK1A1 CK1A P48729 human CDK5 1020 Q00535 CDK5 human S159 448021 GIPVRCYsAEVVTLW Pkinase X +CSNK1A1 CK1A P48729 human HSP90A 3320 P07900 HSP90AA1 human S726 3180213 LEGDDDtsRMEEVD_ X +CSNK1A1 CK1A P48729 human TDP-43 23435 Q13148 TARDBP human S375 6855909 GsGNNSYsGsNsGAA X +CSNK1A1 CK1A P48729 human CTNNB1 12387 Q02248 Ctnnb1 mouse S45 447488 GATtTAPsLsGkGNP X X 9565; 9564; 24710; 70034; 19807; 96727; 77605 +CSNK1A1 CK1A P48729 human p53 22059 P02340 Tp53 mouse T21 447541 ELPLsQEtFsGLWKL P53_TAD X +CSNK1A1 CK1A P48729 human TDP-43 23435 Q13148 TARDBP human S404 3084635 FNGGFGssMDskssG X +CSNK1A1 CK1A P48729 human ATF-1 466 P18846 ATF1 human S41 15725600 SLsESEEsQDSSDsI X +CSNK1A1 CK1A P48729 human HSP90A 3320 P07900 HSP90AA1 human T725 3180216 PLEGDDDtsRMEEVD X +CSNK1A1 CK1A P48729 human p53 7157 P04637 TP53 human S20 447529 PLsQEtFsDLWkLLP P53_TAD X X 9287 +CSNK1A1 CK1A P48729 human JADE1 79960 Q6IE81 JADE1 human S20 35530401 sDDNGsLsTTWSQNS EPL1 X X +CSNK1A1 CK1A P48729 human GJC1 14615 P28229 Gjc1 mouse S387 22598806 KssIssKsGDGKTsV X +CSNK1A1 CK1A P48729 human NFM P16053 NEFM chicken S464 18012945 TKVEDEKsEMEDALs X +CSNK1A1 CK1A P48729 human eIF2B-epsilon 192234 Q64350 Eif2b5 rat S464 449997 DGQFsDDsGADQEKE X +CSNK1A1 CK1A P48729 human DEPTOR 64798 Q8TB45 DEPTOR human S286 21697912 ssMssCGssGyFsss X X +CSNK1A1 CK1A P48729 human TDP-43 23435 Q13148 TARDBP human S91 6855905 kMDEtDAssAVkVKR X +CSNK1A1 CK1A P48729 human NFAT4 4775 Q12968 NFATC3 human S215 11507604 PLtsPGGsPGGCPGE X X +CSNK1A1 CK1A P48729 human TDP-43 23435 Q13148 TARDBP human S389 6855917 AIGWGsAsNAGsGsG X +CSNK1A1 CK1A P48729 human OSBP2 23762 Q969R2 OSBP2 human S768 15721697 HssPssPsSDGKQKT Oxysterol_BP X +CSNK1A1 CK1A P48729 human ATF-1 466 P18846 ATF1 human S50 15725603 DSSDsIGssQKAHGI pKID X +CSNK1A1 CK1A P48729 human LRP6 4040 O75581 LRP6 human S1607 21241903 HLYPPPPsPCTDss_ X +CSNK1A1 CK1A P48729 human TDP-43 23435 Q13148 TARDBP human S292 6855918 NQGGFGNsrGGGAGL X +CSNK1A1 CK1A P48729 human UVRAG 7405 Q9P2Y5 UVRAG human S522 471489 QyktPPPsyNSALAQ X X +CSNK1A1 CK1A P48729 human AGO2 27161 Q9UKV8 AGO2 human S828 31082605 EHDsAEGsHtsGQsN X X +CSNK1A1 CK1A P48729 human YB-1 4904 P67809 YBX1 human S176 470445 EkNEGsEsAPEGQAQ X +CSNK1A1 CK1A P48729 human GJC1 14615 P28229 Gjc1 mouse S384 22598805 GSNKssIssKsGDGK X +CSNK1A1 CK1A P48729 human PHLPP 23239 O60346 PHLPP1 human S1359 22769300 VPRPHVQsVLLtPQD PP2C X +CSNK1A1 CK1A P48729 human AGO2 27161 Q9UKV8 AGO2 human S824 27443092 LVDKEHDsAEGsHts X X +CSNK1A1 CK1A P48729 human hnRNP C1/C2 3183 P07910 HNRNPC human S299 448834 EGEDDRDsANGEDDs X X +CSNK1A1 CK1A P48729 human TDP-43 23435 Q13148 TARDBP human S92 6855902 MDEtDAssAVkVKRA X +CSNK1A1 CK1A P48729 human APC 324 P25054 APC human S1505 452096 DGFsCsssLsALsLD APC_r X +CSNK1A1 CK1A P48729 human NFAT4 4775 Q12968 NFATC3 human S207 11507602 AARFtLGsPLtsPGG X X +CSNK1A1 CK1A P48729 human GJC1 14615 P28229 Gjc1 mouse S326 15499912 AQEQQYGsHEEHLPA X +CSNK1A1 CK1A P48729 human LRP6 4040 O75581 LRP6 human T1572 3802448 EPVPPPPtPRsQyLs X +CSNK1A1 CK1A P48729 human NFM P16053 NEFM chicken S528 448043 EEEEAAKsDAAEEGG X +CSNK1A1 CK1A P48729 human FMR1 14265 P35922 Fmr1 mouse S499 469583 NSEAsNAsETESDHR FXMRP1_C_core X +CSNK1A1 CK1A P48729 human OSBP2 23762 Q969R2 OSBP2 human S763 31727226 CSKVMHssPssPsSD Oxysterol_BP X +CSNK1A1 CK1A P48729 human STX1A 116470 P32851 Stx1a rat T21 451260 sDDDDDVtVtVDRDR X +CSNK1A1 CK1A P48729 human TDP-43 23435 Q13148 TARDBP human S342 6855921 GMMGMLAsQQNQsGP X +CSNK1A1 CK1A P48729 human CREM 12916 P27699 Crem mouse S156 450064 PKIEEEKsEEEGTPP X +CSNK1A1 CK1A P48729 human GJA1 24392 P08050 Gja1 rat S328 449993 GQAGstIsNsHAQPF Connexin43 X X +CSNK1A1 CK1A P48729 human EIF6 3692 P56537 EIF6 human S174 17535702 IEDQDELssLLQVPL eIF-6 X +CSNK1A1 CK1A P48729 human DEPTOR 64798 Q8TB45 DEPTOR human S263 7101486 RKstsFMsVsPsKEI X +CSNK1A1 CK1A P48729 human TDP-43 23435 Q13148 TARDBP human S183 4769419 kLPNskQsQDEPLRS X +CSNK1A1 CK1A P48729 human LSD1 23028 O60341 KDM1A human S687 57786403 HVGsTTAsRGELFLF Amino_oxidase X +CSNK1A1 CK1A P48729 human PHLPP 23239 O60346 PHLPP1 human S1381 22769301 KGLWDsLsVEEAVEA PP2C X +CSNK1A1 CK1A P48729 human PARK2 5071 O60260 PRKN human S101 454420 GCEREPQsLTRVDLs X +CSNK1A1 CK1A P48729 human TDP-43 23435 Q13148 TARDBP human Y4 6855900 ____MsEyIRVtEDE TDP43_N X +CSNK1A1 CK1A P48729 human NFAT4 4775 Q12968 NFATC3 human T210 11507603 FtLGsPLtsPGGsPG X X +CSNK1A1 CK1A P48729 human TDP-43 23435 Q13148 TARDBP human S369 6855907 EPNQAFGsGNNSYsG X +CSNK1A1 CK1A P48729 human CDC25A 993 P30304 CDC25A human S79 450247 QRMGssEstDsGFCL X X +CSNK1A1 CK1A P48729 human TDP-43 23435 Q13148 TARDBP human S377 6855915 GNNSYsGsNsGAAIG X +CSNK1A1 CK1A P48729 human BHLHB2 8553 O14503 BHLHE40 human S243 36324900 GSDTDTDsGYGGESE X X +CSNK1A1 CK1A P48729 human DEPTOR 64798 Q8TB45 DEPTOR human S291 4723858 CGssGyFsssPtLss X +CSNK1A1 CK1A P48729 human CREB 1385 P16220 CREB1 human S94 451807 QISTIAEsEDsQEsV X +CSNK1A1 CK1A P48729 human AGO2 27161 Q9UKV8 AGO2 human T830 62849200 DsAEGsHtsGQsNGR X X +CSNK1A1 CK1A P48729 human DACT1 59036 Q8R4A3 Dact1 mouse S704 1833062500 GDSESSVsEGDFVGE Dapper X +CSNK1A1 CK1A P48729 human TDP-43 23435 Q13148 TARDBP human S350 6855911 QQNQsGPsGNNQNQG X +CSNK1A1 CK1A P48729 human GYS1 100008660 P13834 GYS1 rabbit S8 449898 MPLSRTLsVSsLPGL X +RIPK1 RIPK1 Q13546 human RIPK1 8737 Q13546 RIPK1 human S15 20536002 NVIKMkssDFLEsAE X +RIPK1 RIPK1 Q13546 human RIPK1 8737 Q13546 RIPK1 human S166 27116401 LAsFkMWskLNNEEH PK_Tyr_Ser-Thr X X 65746; 44590; 96323 +RIPK1 RIPK1 Q13546 human DAB2IP 153090 Q5VWQ8 DAB2IP human S728 478274 PsPARsSsYSEANEP DUF3498 X +RIPK1 RIPK1 Q13546 human RIPK1 8737 Q13546 RIPK1 human S14 20536000 LNVIKMkssDFLEsA X 53487 +RIPK1 RIPK1 Q13546 human RIPK1 8737 Q13546 RIPK1 human S20 27116400 kssDFLEsAELDsGG PK_Tyr_Ser-Thr X +RIPK1 RIPK1 Q13546 human RIPK1 19766 Q60855 Ripk1 mouse S166 27116401 VAsFKTWsKLtKEKD PK_Tyr_Ser-Thr X 31122; 53286 +RIPK1 RIPK1 Q13546 human RIPK1 8737 Q13546 RIPK1 human S161 20536001 IADLGLAsFkMWskL PK_Tyr_Ser-Thr X +RIPK1 RIPK1 Q13546 human STAT1 20846 P42225 Stat1 mouse S727 447753 tDNLLPMsPEEFDEM STAT1_TAZ2bind X 9177; 8826; 62390 +Cdk2 CDK2 P97377 mouse MyoD 17927 P10085 Myod1 mouse S200 40684505 SGDSDASsPRsNCSD Myf5 X +Cdk2 CDK2 P97377 mouse B-Myb 17865 P48972 Mybl2 mouse T524 450112 DNtPHtPtPFKNALE Cmyb_C X +Cdk2 CDK2 P97377 mouse FOXO1A 2308 Q12778 FOXO1 human S249 471071 EGGkSGksPrRrAAs X +Cdk2 CDK2 P97377 mouse NRF1 4899 Q16656 NRF1 human S102 1868914505 HVFEsNPsIRKRQQT Nrf1_DNA-bind X +Cdk2 CDK2 P97377 mouse CTNNB1 84353 Q9WU82 Ctnnb1 rat S45 447488 GATtTAPsLSGkGNP X 9565; 24710; 70034; 19807; 96727; 77605 +Cdk2 CDK2 P97377 mouse B-Myb 17865 P48972 Mybl2 mouse T447 452026 NSLtPKStPVkTLPF X +Cdk2 CDK2 P97377 mouse B-Myb 17865 P48972 Mybl2 mouse S581 450115 RKPGLRRsPIKKVRK Cmyb_C X +Cdk2 CDK2 P97377 mouse CTNNB1 84353 Q9WU82 Ctnnb1 rat S33 447487 QQQSYLDsGIHsGAT X 9561; 2009; 4270; 13537; 41334; 60180 +Cdk2 CDK2 P97377 mouse GANP 54387 Q9WUU9 Mcm3ap mouse S502 448619 FWHKKKIsPSKKLFP X +Cdk2 CDK2 P97377 mouse CIZ1 68379 Q8VEH2 Ciz1 mouse T192 22648005 ARtPSSttPNRKDSS X +Cdk2 CDK2 P97377 mouse FOXO1A 2308 Q12778 FOXO1 human S298 471972 QFskWPAsPGsHsND X +Cdk2 CDK2 P97377 mouse MDM2 17246 P23804 Mdm2 mouse T216 450150 SSSESTEtPSHQDLD X +Cdk2 CDK2 P97377 mouse Rb 5925 P06400 RB1 human S795 447979 sPykFPssPLrIPGG Rb_C X 9301 +Cdk2 CDK2 P97377 mouse SOX2 20674 P48432 Sox2 mouse S39 18913847 TGGNQkNsPDRVKRP X +Cdk2 CDK2 P97377 mouse B-Myb 17865 P48972 Mybl2 mouse S396 449253 RGELIPIsPSTEFGG X +Cdk2 CDK2 P97377 mouse C/EBP-beta 1051 P17676 CEBPB human S76 456166 HERAIDFsPyLEPLG X +Cdk2 CDK2 P97377 mouse UBF 21429 P25976 Ubtf mouse S484 450180 DRGKLPEsPKRAEEI HMG_box_5 X +Cdk2 CDK2 P97377 mouse B-Myb 17865 P48972 Mybl2 mouse T408 450108 FGGSGIGtPPSVLKR X +Cdk2 CDK2 P97377 mouse SMAD3 4088 P84022 SMAD3 human T179 451177 PQSNIPEtPPPGYLS X +Cdk2 CDK2 P97377 mouse SMAD3 4088 P84022 SMAD3 human S213 451180 NLsPNPMsPAHNNLD X +Cdk2 CDK2 P97377 mouse B-Myb 17865 P48972 Mybl2 mouse T522 450111 SMDNtPHtPtPFKNA Cmyb_C X +Cdk2 CDK2 P97377 mouse p27Kip1 1027 P46527 CDKN1B human T187 447875 NAGsVEQtPKKPGLR X +Cdk2 CDK2 P97377 mouse NRF1 4899 Q16656 NRF1 human S136 23255800 QAIVLCIsPskPNPV Nrf1_DNA-bind X +Cdk2 CDK2 P97377 mouse CTNNB1 84353 Q9WU82 Ctnnb1 rat S37 447582 YLDsGIHsGATtTAP X 9561; 2009; 4270; 13537; 41334; 60180 +Cdk2 CDK2 P97377 mouse B-Myb 17865 P48972 Mybl2 mouse S283 450113 REYQEFssPEtsLPY X +Cdk2 CDK2 P97377 mouse B-Myb 17865 P48972 Mybl2 mouse S455 450114 PVkTLPFsPSQFLNF Cmyb_C X +Cdk2 CDK2 P97377 mouse STMN1 16765 P54227 Stmn1 mouse S38 448556 sVPdFPLsPPKKKDL Stathmin X 3426; 4191 +Cdk2 CDK2 P97377 mouse E2F5 13559 Q61502 E2f5 mouse T251 448010 SQSSTSVtPQKSTMA X X +Cdk2 CDK2 P97377 mouse CIZ1 68379 Q8VEH2 Ciz1 mouse T191 22648006 QARtPSSttPNRKDS X +Cdk2 CDK2 P97377 mouse CDK7 12572 Q03147 Cdk7 mouse S164 450041 GLAKsFGsPNRAytH Pkinase X +Cdk2 CDK2 P97377 mouse C/EBP-beta 12608 P28033 Cebpb mouse T188 447878 sSssPPGtPSPADAK X X 3084 +Cdk2 CDK2 P97377 mouse B-Myb 17865 P48972 Mybl2 mouse T497 450109 tPLHRDKtPLHQKYP Cmyb_C X +Cdk2 CDK2 P97377 mouse GRASP65 56082 O35254 Gorasp1 rat S277 455582 EQLPGPGsPGHGTAD X +Cdk2 CDK2 P97377 mouse SMAD3 4088 P84022 SMAD3 human T8 452179 MSSILPFtPPIVkRL X +Cdk2 CDK2 P97377 mouse SOX2 20674 P48432 Sox2 mouse S253 6738002 VksEASSsPPVVtSS X 92186 +Cdk2 CDK2 P97377 mouse B-Myb 17865 P48972 Mybl2 mouse T490 452027 SQKVVVTtPLHRDKt Cmyb_C X +Cdk2 CDK2 P97377 mouse B-Myb 17865 P48972 Mybl2 mouse T519 450110 QKYSMDNtPHtPtPF Cmyb_C X +Cdk2 CDK2 P97377 mouse CTNNB1 84353 Q9WU82 Ctnnb1 rat T41 447583 GIHsGATtTAPsLSG X 9561; 9565; 4270; 13537; 41334; 60180 +Cdk2 CDK2 P97377 mouse UBF 21429 P25976 Ubtf mouse S389 450170 INKKQTTsPASKKPS X X +Cdk2 CDK2 P97377 mouse B-Myb 17865 P48972 Mybl2 mouse T267 450107 ADLGEVRtPEPPESL X +Syk Syk Q64725 rat SLP76 155918 Q920L0 Lcp2 rat Y128 448219 DGEDDGDyESPNEEE X +Syk Syk Q64725 rat LAT O70601 Lat rat Y234 448006 DGEEAPDyENLQELN LAT X +CILK1 ICK Q9UPZ9 human BAT3 7917 P46379 BAG6 human T1080 470032 AAGARPLtsPEsLSR X +CILK1 ICK Q9UPZ9 human ICK 56542 Q9JKV2 Cilk1 mouse Y159 456052 SRPPytDyVStRWYR Pkinase X +CILK1 ICK Q9UPZ9 human KIF3A 11127 Q9Y496 KIF3A human T672 33668514 MkLERPRtSKGKARP X +CILK1 ICK Q9UPZ9 human Raptor 57521 Q8N122 RPTOR human T908 23940710 LPSGRPGtTGPAGAQ X X +Cdk5 CDK5 P49615 mouse Tau iso8 4137 P10636-8 MAPT human T231 449079 KKVAVVRtPPKsPss X 20473; 71429 +Cdk5 CDK5 P49615 mouse PIK3C3 225326 Q6PF93 Pik3c3 mouse T159 14659500 DGSEPTRtPGRTssT PI3K_C2 X +Cdk5 CDK5 P49615 mouse GJA1 14609 P23242 Gja1 mouse S282 448854 tAPLsPMsPPGykLV X +Cdk5 CDK5 P49615 mouse PAK1 18479 O88643 Pak1 mouse T212 448176 VIEPLPVtPtRDVAt X X +Cdk5 CDK5 P49615 mouse DRD2 1813 P14416 DRD2 human S321 31010702 GLHSTPDsPAkPEKN 7tm_1 X +Cdk5 CDK5 P49615 mouse Lmr1 iso2 11302 Q80YE4-2 Aatk mouse S34 14364500 ADFSEQGsPAAAAQT X +Cdk5 CDK5 P49615 mouse CHIP 56424 Q9WUD1 Stub1 mouse S20 453857 LGtGGGGsPDksPsA X X +Cdk5 CDK5 P49615 mouse CTNND2 18163 O35927 Ctnnd2 mouse S357 4697626 IGTyATLsPtKRLVH X +Cdk5 CDK5 P49615 mouse RAB3IL1 74760 Q8VDV3 Rab3il1 mouse S169 467058 VItstPAsPNRELHP Sec2p X +Cdk5 CDK5 P49615 mouse DAB1 iso2 13131 P97318-2 Dab1 mouse S481 479420 STtPSTNsPPtPAPR X X +Cdk5 CDK5 P49615 mouse CASK 12361 O70589 Cask mouse S51 1261103 DVAKFTssPGLsTED Pkinase X +Cdk5 CDK5 P49615 mouse SynGAP 240057 F6SEU4 Syngap1 mouse S857 37045603 GPGGRLNsSSVsNLA DUF3498 X +Cdk5 CDK5 P49615 mouse CDK5R1 8851 Q15078 CDK5R1 human T138 471393 PAVTSAGtPKRVIVQ CDK5_activator X +Cdk5 CDK5 P49615 mouse RHOQ 104215 Q8R527 Rhoq mouse T189 5996401 ILTPKKHtVKKRIGS X +Cdk5 CDK5 P49615 mouse ESYT1 23943 Q3U7R1 Esyt1 mouse S314 15409842 QDVAQLRsPLPRGII X +Cdk5 CDK5 P49615 mouse Spinophilin 217124 Q6R891 Ppp1r9b mouse S17 455340 GGPLRsAsPHRSAYE X X +Cdk5 CDK5 P49615 mouse Tau iso8 4137 P10636-8 MAPT human S396 449081 GAEIVyKsPVVsGDt X 9632 +Cdk5 CDK5 P49615 mouse Ezrin 22350 P26040 Ezr mouse T235 449293 YEKDDKLtPkIGFPW FERM_C X X +Cdk5 CDK5 P49615 mouse CRMP-1 1400 Q14194 CRMP1 human T509 454314 PVyEVPAtPKyAtPA X +Cdk5 CDK5 P49615 mouse Tau iso8 4137 P10636-8 MAPT human S404 449082 PVVsGDtsPRHLsNV X 35834; 20194; 98523; 91600; 49562 +Cdk5 CDK5 P49615 mouse RAB3IL1 171452 Q99NH3 Rab3il1 rat S169 467058 VITSTPAsPNRELHP Sec2p X +Cdk5 CDK5 P49615 mouse DAB1 iso3 13131 P97318-3 Dab1 mouse S246 479425 PVSSLVQsPAAERAE X X +Cdk5 CDK5 P49615 mouse SynGAP 240057 F6SEU4 Syngap1 mouse S817 33636339 rPPLARSsPAyCtss DUF3498 X +Cdk5 CDK5 P49615 mouse RAB3IL1 74760 Q8VDV3 Rab3il1 mouse S180 467059 ELHPQLLsPtKAGPR X +Cdk5 CDK5 P49615 mouse DAB1 iso2 13131 P97318-2 Dab1 mouse T470 479418 DISQLNLtPVTSTtP X X +Cdk5 CDK5 P49615 mouse CTNND2 18163 O35927 Ctnnd2 mouse S300 14910701 rGssPKQsPsRLAKS X +Cdk5 CDK5 P49615 mouse JIP1 19099 Q9WVI9 Mapk8ip1 mouse T201 449954 PLKTGEQtPPHEHIC X +Cdk5 CDK5 P49615 mouse SynGAP 240057 F6SEU4 Syngap1 mouse S788 19014968 MDMARLPsPtKEkPP DUF3498 X +Cdk5 CDK5 P49615 mouse P2X2 114115 P49653 P2rx2 rat T372 183815300 KKFDKVRtPKHPSSR X X +Cdk5 CDK5 P49615 mouse SynGAP 240057 F6SEU4 Syngap1 mouse S743 27720871 RQSERTRsQPMVLRG DUF3498 X +Cdk5 CDK5 P49615 mouse CDK5R2 8941 Q13319 CDK5R2 human S173 18007784 APPVPGGsPRRVIVQ CDK5_activator X +Cdk5 CDK5 P49615 mouse GJA1 14609 P23242 Gja1 mouse S279 448853 SsPtAPLsPMsPPGy X +Cdk5 CDK5 P49615 mouse CASK 12361 O70589 Cask mouse S395 1261102 DKINTkSsPQIRNPP L27 X +Cdk5 CDK5 P49615 mouse MST3 223255 Q99KH8 Stk24 mouse S79 33602703 TVLSQCDsPyVTKYY Pkinase X +Cdk5 CDK5 P49615 mouse DAB1 iso2 13131 P97318-2 Dab1 mouse T385 479416 AMFQGPLtPLATVPG X X +Cdk5 CDK5 P49615 mouse p27Kip1 12576 P46414 Cdkn1b mouse S10 447874 NVRVsNGsPsLERMD X +Cdk5 CDK5 P49615 mouse DAB1 iso2 13131 P97318-2 Dab1 mouse S515 479423 IFEEGFEsPSKSEEQ X X +Cdk5 CDK5 P49615 mouse Vimentin 22352 P20152 Vim mouse S56 451514 sRsLysssPGGAyVt Filament_head X X 3877; 7391 +Cdk5 CDK5 P49615 mouse SEPT5 iso2 100044138 XP_001480843 LOC100044138 mouse S17 475075 RLVEQLLsPRTQAQR X +Cdk5 CDK5 P49615 mouse Doublecortin 13193 O88809 Dcx mouse S287 451360 AAAGPKAsPtPQKTS X +Cdk5 CDK5 P49615 mouse Tau 17762 P10637 Mapt mouse S688 449081 GAEIVyKsPVVsGDt X 9632 +Cdk5 CDK5 P49615 mouse PPP1R1A 58200 Q9ERT9 Ppp1r1a mouse S67 447758 LKSTLsMsPRQRKKM DARPP-32 X X +Cdk5 CDK5 P49615 mouse Doublecortin 13193 O88809 Dcx mouse S339 451359 sPIStPtsPGsLRKH X 3453; 14053 +Cdk5 CDK5 P49615 mouse DAB1 iso2 13131 P97318-2 Dab1 mouse T484 479421 PSTNsPPtPAPRQSs X X +Cdk5 CDK5 P49615 mouse CRMP-1 1400 Q14194 CRMP1 human S522 1295503 PAPsAKssPsKHQPP X +Cdk5 CDK5 P49615 mouse coronin 1A 12721 O89053 Coro1a mouse T418 4701031 DsARRRAtPEPsGtP Trimer_CC X X +Cdk5 CDK5 P49615 mouse STAT3 20848 P42227 Stat3 mouse S727 448191 NtIDLPMsPRTLDSL X X 9134; 9136; 34911; 94994; 49081; 58978; 87544; 71958; 50804 +Cdk5 CDK5 P49615 mouse Doublecortin 13193 O88809 Dcx mouse S297 451111 PQKTSAKsPGPMRRs X X 4605 +Cdk5 CDK5 P49615 mouse IP3R1 16438 P11881 Itpr1 mouse S421 450268 VMLKIGTsPLKEDkE MIR X +Cdk5 CDK5 P49615 mouse Doublecortin 13193 O88809 Dcx mouse T289 451362 AGPKAsPtPQKTSAK X +Cdk5 CDK5 P49615 mouse Tau iso8 4137 P10636-8 MAPT human S202 447928 sGyssPGsPGtPGsR X 39357; 30505 +Cdk5 CDK5 P49615 mouse APE1 11792 P28352 Apex1 mouse T232 14645304 NKkNAGFtPQERQGF Exo_endo_phos X +Cdk5 CDK5 P49615 mouse CDK5R1 8851 Q15078 CDK5R1 human S8 471392 MGTVLSLsPSYRKAT X +Cdk5 CDK5 P49615 mouse DAB1 iso2 13131 P97318-2 Dab1 mouse S491 479422 tPAPRQSsPSKSSAS X X +Cdk5 CDK5 P49615 mouse Doublecortin 13193 O88809 Dcx mouse S332 451363 StPKsKQsPIStPts X +Cdk5 CDK5 P49615 mouse CACNA1C 12288 Q01815 Cacna1c mouse S783 457631 KKLARTAsPEKKQEV X X +Cdk5 CDK5 P49615 mouse DAB1 iso2 13131 P97318-2 Dab1 mouse T476 479419 LtPVTSTtPSTNsPP X X +Cdk5 CDK5 P49615 mouse FAK 14083 P34152 Ptk2 mouse S732 450196 SSEGFYPsPQHMVQT X X +Cdk5 CDK5 P49615 mouse NMDAR2B 14812 Q01097 Grin2b mouse S1116 3984496 yRRRPPRsPDHKRYF NMDAR2_C X X +Cdk5 CDK5 P49615 mouse RAB3IL1 171452 Q99NH3 Rab3il1 rat S180 467059 ELHPQLLsPTKAGPR X +Cdk5 CDK5 P49615 mouse RASGRF1 19417 P27671 Rasgrf1 mouse S737 469604 PLAIGtSsPsRRRKL RasGEF_N X +Cdk5 CDK5 P49615 mouse Huntingtin 15194 P42859 Htt mouse S1179 465620 EQASTPMsPKKVGEA X +Cdk5 CDK5 P49615 mouse PRDX2 21672 Q61171 Prdx2 mouse T89 487517 THLAWINtPRkEGGL AhpC-TSA X X +Cdk5 CDK5 P49615 mouse DAB1 iso2 13131 P97318-2 Dab1 mouse S550 479424 EPSGDNIsPQDGS__ X X +Cdk5 CDK5 P49615 mouse SynGAP 240057 F6SEU4 Syngap1 mouse T790 33636249 MARLPsPtKEkPPPP DUF3498 X +Cdk5 CDK5 P49615 mouse Doublecortin 13193 O88809 Dcx mouse T326 451361 TSSsQLStPKsKQsP X +Cdk5 CDK5 P49615 mouse STMN1 16765 P54227 Stmn1 mouse S38 448556 sVPdFPLsPPKKKDL Stathmin X 3426; 4191 +Cdk5 CDK5 P49615 mouse MEK1 26395 P31938 Map2k1 mouse T286 448286 VEGDAAEtPPRPRtP Pkinase X X 9127 +Cdk5 CDK5 P49615 mouse DAB1 iso2 13131 P97318-2 Dab1 mouse S400 479417 TNDSARSsPQSDKPR X X +Cdk5 CDK5 P49615 mouse DAB1 13131 P97318 Dab1 mouse S524 479422 TPAPRQSsPSKSSAS X +Cdk5 CDK5 P49615 mouse SNTB2 20650 Q61235 Sntb2 mouse S75 471147 NRGLGPPsPPAPPRG X +Cdk5 CDK5 P49615 mouse Bcl-2 12043 P10417 Bcl2 mouse S70 448395 RDMAARtsPLRPLVA X X +Cdk5 CDK5 P49615 mouse Tau 17762 P10637 Mapt mouse T497 447933 ssPGsPGtPGsRsRt X 25377; 43964; 53001; 49561; 20060; 33032; 30505; 20739; 98160 +Cdk5 CDK5 P49615 mouse Tau iso8 4137 P10636-8 MAPT human T181 447932 ktPPAPktPPssGEP X 12885; 66224; 62672 +Cdk5 CDK5 P49615 mouse nestin 18008 Q6P5H2 Nes mouse T1554 449819 GETLPDStPLGLYLK X +Cdk5 CDK5 P49615 mouse DARPP-32 19049 Q60829 Ppp1r1b mouse T75 448048 RPNPCAYtPPSLKAV DARPP-32 X 2301 +Cdk5 CDK5 P49615 mouse MEKK1 26401 P53349 Map3k1 mouse T280 3951974 PFQSGRItPPRRAPs X +Cdk5 CDK5 P49615 mouse Tau 17762 P10637 Mapt mouse S494 447928 sGyssPGsPGtPGsR X 39357; 30505 +Cdk5 CDK5 P49615 mouse TrkB 25054 Q63604 Ntrk2 rat S478 478364 SNDDDSAsPLHHISN X +Cdk5 CDK5 P49615 mouse PAK1 29431 P35465 Pak1 rat T211 448176 VIEPLPVtPTRDVAT X +Cdk5 CDK5 P49615 mouse CACNA1B 257648 Q02294 Cacna1b rat S2016 25792205 TQPAPNAsPMKRSIS X +Cdk5 CDK5 P49615 mouse CDK16 18555 Q04735 Cdk16 mouse S95 453454 tssDEVQsPVRVRMR X +Cdk5 CDK5 P49615 mouse Huntingtin 15194 P42859 Htt mouse S1159 465621 LTNPPSLsPIRRKGK X +Cdk5 CDK5 P49615 mouse CDK5R2 8941 Q13319 CDK5R2 human S8 15499459 MGTVLSLsPASSAKG X +Cdk5 CDK5 P49615 mouse Tau 17762 P10637 Mapt mouse S491 447927 GERsGyssPGsPGtP X 29957 +Cdk5 CDK5 P49615 mouse PPP1R1A 58977 P19103 Ppp1r1a rat S6 478275 __MEPDNsPRKIQFT DARPP-32 X +Cdk5 CDK5 P49615 mouse axin 1 12005 O35625 Axin1 mouse T480 451091 HVQRVMRtPGCQsPG Axin_b-cat_bind X +Cdk5 CDK5 P49615 mouse Doublecortin 13193 O88809 Dcx mouse S28 451358 SRMNGLPsPTHSAHC X +Cdk5 CDK5 P49615 mouse TrkB 18212 P15209 Ntrk2 mouse S478 478364 SNDDDsAsPLHHISN X X +Cdk5 CDK5 P49615 mouse p27Kip1 12576 P46414 Cdkn1b mouse T187 447875 NAGtVEQtPKKPGLR X X +Cdk5 CDK5 P49615 mouse CDK5R2 8941 Q13319 CDK5R2 human T84 4697544 KKGSKKVtPKPASTG X +Cdk5 CDK5 P49615 mouse VACAMKL 235604 Q3UHL1 Camkv mouse T345 60179300 QSASDAAtPGAAGGA X +Cdk5 CDK5 P49615 mouse TH 21823 P24529 Th mouse S31 448544 KQAEAVtsPRFIGRR TOH_N X 3370; 13041 +Pdpk1 PDK1 Q9Z2A0 mouse RSK2 110651 P18654 Rps6ka3 mouse S369 448064 TAKtPKDsPGIPPsA Pkinase_C X +Pdpk1 PDK1 Q9Z2A0 mouse PKCZ 5590 Q05513 PRKCZ human T410 447510 GPGDtTstFCGtPNy Pkinase X X 9378; 2060 +Pdpk1 PDK1 Q9Z2A0 mouse SPHK2 56848 Q9NRA0 SPHK2 human S421 486447 sPLHRsVsDLPLPLP X +Pdpk1 PDK1 Q9Z2A0 mouse RSK2 110651 P18654 Rps6ka3 mouse T577 450152 AENGLLMtPCYtANF Pkinase X +Pdpk1 PDK1 Q9Z2A0 mouse PDK1 18607 Q9Z2A0 Pdpk1 mouse S399 448582 SSSSSSHsLSTVETS X +Pdpk1 PDK1 Q9Z2A0 mouse RSK2 110651 P18654 Rps6ka3 mouse S227 448063 DHEKKAysFCGtVEy Pkinase X 3556 +Pdpk1 PDK1 Q9Z2A0 mouse PKACA 18747 P05132 Prkaca mouse T198 448459 RVKGRtWtLCGtPEY Pkinase X 4781; 5661 +Pdpk1 PDK1 Q9Z2A0 mouse PDK1 18607 Q9Z2A0 Pdpk1 mouse S244 447693 SKQARANsFVGtAQy Pkinase X X 3061; 3438 +Pdpk1 PDK1 Q9Z2A0 mouse PDK1 18607 Q9Z2A0 Pdpk1 mouse T516 450132 PEAKNFKtFFVHTPN PH_3 X +Pdpk1 PDK1 Q9Z2A0 mouse SPHK2 56848 Q9NRA0 SPHK2 human S419 486446 AHsPLHRsVsDLPLP X +Pdpk1 PDK1 Q9Z2A0 mouse RSK2 110651 P18654 Rps6ka3 mouse S386 448065 HQLFRGFsFVAITSD Pkinase_C X 9341; 9335; 13575; 11989; 12032; 75266; 93317; 13397; 13588 +Pdpk1 PDK1 Q9Z2A0 mouse Akt1 11651 P31750 Akt1 mouse T308 447856 KDGAtMKtFCGtPEy Pkinase X X 5106; 2965; 9275; 4056; 5056; 13842; 13038; 43506; 48646; 86758; 80722; 77440; 80556 +Prkcg PKCG P63318 mouse CRMP-2 12934 O08553 Dpysl2 mouse T555 448084 DNIPRRttQRIVAPP X +Prkcg PKCG P63318 mouse RKIP 29542 P31044 Pebp1 rat S153 448755 RGkFkVEsFRKKYHL PBP X +Prkcg PKCG P63318 mouse CAMK2B 12323 P28652 Camk2b mouse S315 451707 MLAtRNFsVGRQTtA X X +Prkcg PKCG P63318 mouse SYN1 20964 O88935 Syn1 mouse S605 450236 AGPtRQAsQAGPGPr X 88246 +Prkcg PKCG P63318 mouse SYN1 20964 O88935 Syn1 mouse S9 448378 NYLRRRLsDsNFMAN Synapsin_N X 2311; 67605 +STK24 MST3 Q9Y6E0 human AMPKA1 5562 Q13131 PRKAA1 human T183 448786 sDGEFLRtsCGsPNy Pkinase X 2535; 2531; 4188; 5256; 50081; 74281 +STK24 MST3 Q9Y6E0 human KEPI 81706 Q8TAE6 PPP1R14C human T73 10296602 RHQQGKVtVkYDRKE PP1_inhibitor X +STK24 MST3 Q9Y6E0 human TAO1 57551 Q7L7X3 TAOK1 human T440 23150854 RNREHFAtIRtAsLV X +STK24 MST3 Q9Y6E0 human QIK 23235 Q9H0K1 SIK2 human T175 456035 kSGELLAtWCGSPPY Pkinase X +STK24 MST3 Q9Y6E0 human RAB8A 4218 P61006 RAB8A human T72 4709152 AGQERFRtITTAyyR Ras X +STK24 MST3 Q9Y6E0 human MST3 8428 Q9Y6E0 STK24 human T190 468211 DtQIkRNtFVGtPFW Pkinase X X +STK24 MST3 Q9Y6E0 human SIK 150094 P57059 SIK1 human T182 456034 kSGEPLStWCGSPPY Pkinase X +STK24 MST3 Q9Y6E0 human TAO1 216965 Q5F2E8 Taok1 mouse T440 23150854 RNREHFAtIRTAsLV X +STK24 MST3 Q9Y6E0 human QSK 23387 Q9Y2K2 SIK3 human T221 456036 TPGQLLKtWCGSPPY Pkinase X X +STK24 MST3 Q9Y6E0 human TAO2 381921 Q6ZQ29 Taok2 mouse T475 23150863 RNRDHFAtIRTAsLV X +STK24 MST3 Q9Y6E0 human NDR2 23012 Q9Y2H1 STK38L human T442 451133 DWVFLNytyKRFEGL Pkinase_C X X +STK24 MST3 Q9Y6E0 human AMPKA2 5563 P54646 PRKAA2 human T172 448026 sDGEFLRtsCGsPNy Pkinase X X 2535; 2531; 5256; 50081; 74281 +STK24 MST3 Q9Y6E0 human Elf-2 1998 Q15723 ELF2 human S107 4779292 EALLHMEsPTCLRDS Elf-1_N X +Speg SPEG Q62407 mouse RYR2 20191 E9Q401 Ryr2 mouse S2367 4777888 GPsPTSGssKTLDIE X +DYRK2 DYRK2 Q92630 human GLI2 14633 Q0VGT2 Gli2 mouse S385 3339001 AEGLRPAsPLGLTQE X +DYRK2 DYRK2 Q92630 human SIAH2 6478 O43255 SIAH2 human S68 5393502 GGGAGPVsPQHHELT X +DYRK2 DYRK2 Q92630 human CARHSP1 23589 Q9Y2V2 CARHSP1 human S41 455702 LRGNVVPsPLPtRRt X +DYRK2 DYRK2 Q92630 human Doublecortin iso2 1641 O43602-2 DCX human S306 454122 GPMRRSKsPADSANG X +DYRK2 DYRK2 Q92630 human CDC25A 993 P30304 CDC25A human S283 58934700 PErsQEEsPPGSTKr M-inducer_phosp X X +DYRK2 DYRK2 Q92630 human SIAH2 6478 O43255 SIAH2 human T119 26371004 PTCRGALtPSIRNLA X +DYRK2 DYRK2 Q92630 human KATNA1 11104 O75449 KATNA1 human S42 26401200 QMNKYLYsVkDTYLQ X +DYRK2 DYRK2 Q92630 human p53 7157 P04637 TP53 human S46 447536 AMDDLMLsPDDIEQW TAD2 X X 2521 +DYRK2 DYRK2 Q92630 human CDC25A 993 P30304 CDC25A human S321 472278 QSLSLAssPKGTIEN M-inducer_phosp X X +DYRK2 DYRK2 Q92630 human CDC25A 993 P30304 CDC25A human S107 31086927 NPMRRIHsLPQkLLG M-inducer_phosp X X +DYRK2 DYRK2 Q92630 human DYRK2 iso2 8445 Q92630-2 DYRK2 human S483 1874397810 SVKRITEstGAItsI X +DYRK2 DYRK2 Q92630 human CDC25A 993 P30304 CDC25A human S18 449976 RRLLFACsPPPASQP X X +DYRK2 DYRK2 Q92630 human eIF2B-epsilon 192234 Q64350 Eif2b5 rat S539 449906 ELDsRAGsPQLDDIR X +DYRK2 DYRK2 Q92630 human KATNA1 11104 O75449 KATNA1 human S109 23117380 VPVERRPsPGPRKRQ X +DYRK2 DYRK2 Q92630 human DYRK2 iso2 8445 Q92630-2 DYRK2 human T484 1874397812 VKRITEstGAItsIS X +DYRK2 DYRK2 Q92630 human DYRK2 iso2 8445 Q92630-2 DYRK2 human T32 1874397806 SNKRTVLttQPNGLT X +DYRK2 DYRK2 Q92630 human KATNA1 11104 O75449 KATNA1 human T133 26401201 HGNRPSTtVRVHRSS X +DYRK2 DYRK2 Q92630 human RPT3 5704 P43686 PSMC4 human T25 3190483 LSVsRPQtGLsFLGP X X +DYRK2 DYRK2 Q92630 human DYRK2 iso2 8445 Q92630-2 DYRK2 human T488 1874397814 TEstGAItsISKLPP X +DYRK2 DYRK2 Q92630 human DYRK2 iso2 8445 Q92630-2 DYRK2 human T82 1874397808 KVKATPMtPEQAMKQ X +DYRK2 DYRK2 Q92630 human CRMP-1 1400 Q14194 CRMP1 human S522 1295503 PAPsAKssPsKHQPP X +DYRK2 DYRK2 Q92630 human 4E-BP1 1978 Q13541 EIF4EBP1 human S65 447527 FLMECrNsPVtktPP eIF_4EBP X 9451; 9456; 13443 +DYRK2 DYRK2 Q92630 human Snail1 6615 O95863 SNAI1 human S104 455881 GkGsQPPsPPsPAPs X +DYRK2 DYRK2 Q92630 human DYRK2 iso2 8445 Q92630-2 DYRK2 human Y309 454666 EHQRVYTyIQSRFYR Pkinase X +DYRK2 DYRK2 Q92630 human H3F3A 3020 P84243 H3-3A human T45 18545304 PHryrPGtVALrEIR Histone X +DYRK2 DYRK2 Q92630 human CDC25A 993 P30304 CDC25A human S88 458298 DsGFCLDsPGPLDSK M-inducer_phosp X +DYRK2 DYRK2 Q92630 human HSF1 3297 Q00613 HSF1 human S363 455486 DtEGRPPsPPPtstP Vert_HS_TF X +DYRK2 DYRK2 Q92630 human Notch 1 4851 P46531 NOTCH1 human T2511 483083 VPEHPFLtPsPEsPD X X +DYRK2 DYRK2 Q92630 human SIAH2 6478 O43255 SIAH2 human T26 5393503 PPPQPQHtPsPAAPP X +DYRK2 DYRK2 Q92630 human CARHSP1 23589 Q9Y2V2 CARHSP1 human S30 467608 tPRsRERsPsPLRGN X +DYRK2 DYRK2 Q92630 human CDC25A 993 P30304 CDC25A human S320 1874397804 HQSLSLAssPKGTIE M-inducer_phosp X X +DYRK2 DYRK2 Q92630 human CARHSP1 23589 Q9Y2V2 CARHSP1 human S32 467609 RsRERsPsPLRGNVV X +DYRK2 DYRK2 Q92630 human HSF1 3297 Q00613 HSF1 human S307 449046 EPPsPPQsPRVEEAs Vert_HS_TF X +DYRK2 DYRK2 Q92630 human HSF1 3297 Q00613 HSF1 human S320 3849409 AsPGRPssVDtLLsP Vert_HS_TF X X +DYRK2 DYRK2 Q92630 human GYS1 100008660 P13834 GYS1 rabbit S641 448237 YRYPRPAsVPPsPSL Glycogen_syn X +DYRK2 DYRK2 Q92630 human CRMP-4 1809 Q14195 DPYSL3 human S522 458800 PAGsArGsPtRPNPP X +DYRK2 DYRK2 Q92630 human CRMP-2 1808 Q16555 DPYSL2 human S522 448082 PAssAktsPAkQQAP X +DYRK2 DYRK2 Q92630 human GLI2 14633 Q0VGT2 Gli2 mouse S1011 3339000 NLtRNAYsPRPPSIN X +DYRK2 DYRK2 Q92630 human Tau iso8 4137 P10636-8 MAPT human T212 447934 tPGsRsRtPsLPtPP X +DYRK2 DYRK2 Q92630 human DYRK2 iso2 8445 Q92630-2 DYRK2 human S497 1874397818 ISKLPPPsssAsKLR X +DYRK2 DYRK2 Q92630 human DYRK2 iso2 8445 Q92630-2 DYRK2 human T33 11489910 NKRTVLttQPNGLTT X +DYRK2 DYRK2 Q92630 human SIAH2 6478 O43255 SIAH2 human S16 26371003 PsANkPCsKQPPPQP X +DYRK2 DYRK2 Q92630 human HSF1 3297 Q00613 HSF1 human S326 455484 ssVDtLLsPTALIDs Vert_HS_TF X X +DYRK2 DYRK2 Q92630 human 4E-BP1 1978 Q13541 EIF4EBP1 human S101 449033 sQSHLRNsPEDKRAG eIF_4EBP X +DYRK2 DYRK2 Q92630 human CDC25A 993 P30304 CDC25A human S156 1874397800 KkPVRPVsRGCLHSH M-inducer_phosp X X +DYRK2 DYRK2 Q92630 human CDC25A 993 P30304 CDC25A human S185 1874397802 sAPARMLsSNERDSS M-inducer_phosp X X +DYRK2 DYRK2 Q92630 human TBK1 29110 Q9UHD2 TBK1 human S527 50318715 QDIDSRLsPGGSLAD TBK1_CCD1 X +DYRK2 DYRK2 Q92630 human DYRK2 iso2 8445 Q92630-2 DYRK2 human S489 1874397816 EstGAItsISKLPPP X +DYRK2 DYRK2 Q92630 human SIAH2 6478 O43255 SIAH2 human S28 471339 PQPQHtPsPAAPPAA X X +DYRK2 DYRK2 Q92630 human HSF1 3297 Q00613 HSF1 human T323 4169776 GRPssVDtLLsPTAL Vert_HS_TF X +DYRK2 DYRK2 Q92630 human NDEL1 83431 Q9ERR1 Ndel1 mouse S336 1869686801 LGSsRPSsAPGMLPL X +BUB1 BUB1 O43683 human BUB3 9184 O43684 BUB3 human S19 15180600 PPEDGISsVkFSPNT WD40 X +BUB1 BUB1 O43683 human CDC20 991 Q12834 CDC20 human S72 454659 SkVQttPskPGGDRy X +BUB1 BUB1 O43683 human BUB1 699 O43683 BUB1 human T589 3175277 WGIRCNktLAPsPks X +BUB1 BUB1 O43683 human BUB1 699 O43683 BUB1 human S563 479887 RsVSRLPsKPKEEVP X +BUB1 BUB1 O43683 human CDC20 991 Q12834 CDC20 human S41 454658 EAAGPAPsPMRAANR X +BUB1 BUB1 O43683 human CDC20 991 Q12834 CDC20 human S161 454663 QkAtPGssRKtCRYI X +BUB1 BUB1 O43683 human BUB1 699 O43683 BUB1 human S510 31860534 QFQkNVRssGAWGVN X +BUB1 BUB1 O43683 human BUB1 699 O43683 BUB1 human S667 20722783 ksPkQALssHMysAS X +BUB1 BUB1 O43683 human BUB1 699 O43683 BUB1 human S969 20722066 FTAKCETsGFQCVEM Pkinase X +BUB1 BUB1 O43683 human BUB1 699 O43683 BUB1 human T960 50318708 MKLFPkGtIFTAKCE Pkinase X +BUB1 BUB1 O43683 human BUB1 699 O43683 BUB1 human T148 50318709 RLFQTRLtETHLPAQ X +BUB1 BUB1 O43683 human BUB1 699 O43683 BUB1 human T552 50318703 NKPTGARtFGERsVS X +BUB1 BUB1 O43683 human BUB1 699 O43683 BUB1 human T213 50318707 NMERRVItISkSEys X +BUB1 BUB1 O43683 human CDC20 991 Q12834 CDC20 human S153 454661 NRLkVLysQkAtPGs X +BUB1 BUB1 O43683 human STAT3 6774 P40763 STAT3 human S727 448191 NtIDLPMsPrTLDSL X X 9134; 9136; 34911; 94994; 49081; 58978; 87544; 71958; 50804 +BUB1 BUB1 O43683 human CDC20 991 Q12834 CDC20 human S92 454660 AAQMEVAsFLLSkEN X +BUB1 BUB1 O43683 human BUB1 699 O43683 BUB1 human S419 50318705 THEFkPQsGAEIKEG X +BUB1 BUB1 O43683 human BUB1 699 O43683 BUB1 human S679 20722063 sASLLRLsQPAAGGV X +BUB1 BUB1 O43683 human BUB1 699 O43683 BUB1 human T173 50318701 QVLNQMItSksNPGN X +BUB1 BUB1 O43683 human CDC20 991 Q12834 CDC20 human T157 454662 VLysQkAtPGssRKt X +BUB1 BUB1 O43683 human BUB1 699 O43683 BUB1 human S454 50318710 GMVQAtPskVQPsPt X +BUB1 BUB1 O43683 human H2A.1 8329 P0C0S8 H2AC17 human T120 482914 AVLLPkktEsHHkAk Histone_H2A_C X X +BUB1 BUB1 O43683 human BUB1 699 O43683 BUB1 human S511 12667749 FQkNVRssGAWGVNK X +BUB1 BUB1 O43683 human BUB1 699 O43683 BUB1 human S618 50318702 FHkLPVEsVHILEDk X +BUB1 BUB1 O43683 human BUB1 699 O43683 BUB1 human S176 20722779 NQMItSksNPGNNMA X +BUB1 BUB1 O43683 human BUB1 699 O43683 BUB1 human S752 50318706 KLIFKLLsGLskPVS X +BUB1 BUB1 O43683 human BUB1 699 O43683 BUB1 human S525 31084641 KIISSLSsAFHVFED X +BUB1 BUB1 O43683 human BUB1 699 O43683 BUB1 human S198 50318711 SELsGVIsSACDkES X +PRKCE PKCE Q02156 human UGT1A7 54577 Q9HAW7 UGT1A7 human S432 455595 KAVINDKsYkENIMR UDPGT X +PRKCE PKCE Q02156 human Tau iso8 4137 P10636-8 MAPT human S352 487459 DFKDrVQskIGsLDN Tubulin-binding X +PRKCE PKCE Q02156 human CENTA1 11033 O75689 ADAP1 human T276 11380901 GFRkRWFtMDDRRLM PH X +PRKCE PKCE Q02156 human SLC24A2 84550 O54701 Slc24a2 rat S504 471068 PDVRKPAsKKFFPIT X +PRKCE PKCE Q02156 human KEAP1 9817 Q14145 KEAP1 human S602 29606703 TRMTsGRsGVGVAVT X X +PRKCE PKCE Q02156 human TACE 6868 P78536 ADAM17 human T735 449804 kPFPAPQtPGRLQPA X +PRKCE PKCE Q02156 human GIRK4 16521 P48545 Kcnj5 mouse S418 1884003506 VSQATRGsM______ X +PRKCE PKCE Q02156 human K8 16691 P11679 Krt8 mouse S9 484004 sIRVTQKsYkMstsG Keratin_2_head X +PRKCE PKCE Q02156 human TNNI3 511094 P08057 TNNI3 cow S44 450690 AKKKSKIsAsRKLQL X +PRKCE PKCE Q02156 human PKM 5315 P14618 PKM human Y105 450528 FAsDPILyRPVAVAL PK X 3827 +PRKCE PKCE Q02156 human G-alpha i2 2771 P04899 GNAI2 human S144 451341 VQACFGRsREyQLND G-alpha X +PRKCE PKCE Q02156 human CACNA1C 100101555 P15381 CACB rabbit S1928 455278 ASLGRRAsFHLECLK CAC1F_C X +PRKCE PKCE Q02156 human CACNA1B 257648 Q02294 Cacna1b rat S2108 465549 RKQERGRsQERRQPS X +PRKCE PKCE Q02156 human NANOG 79923 Q9H9S0 NANOG human T200 28070707 LPMWSNQtWNNSTWS X X +PRKCE PKCE Q02156 human TNNT2 286816 P13789 TNNT2 cow S195 451755 KAQtERKsGKRQtER Troponin X +PRKCE PKCE Q02156 human GJA1 24392 P08050 Gja1 rat S364 450183 AIVDQRPssRAssRA X +PRKCE PKCE Q02156 human TNNT2 286816 P13789 TNNT2 cow T191 449038 GYIQKAQtERKsGKR Troponin X +PRKCE PKCE Q02156 human NANOG 79923 Q9H9S0 NANOG human S135 17399913 LSNILNLsYKQVKTW Homeodomain X +PRKCE PKCE Q02156 human PKCE 5581 Q02156 PRKCE human S316 2085100 tPDKITNsGQRRkKL X +PRKCE PKCE Q02156 human ZO1 21872 P39447 Tjp1 mouse S168 470469 AsRERsLsPRsDRRs X +PRKCE PKCE Q02156 human NANOG 79923 Q9H9S0 NANOG human S79 28070708 PKGKQPtsAEKSVAK X +PRKCE PKCE Q02156 human G-alpha i2 2771 P04899 GNAI2 human S302 12575206 NkYDEAAsyIQSkFE G-alpha X +PRKCE PKCE Q02156 human PPP1R14A 94274 Q96A00 PPP1R14A human T38 449098 QkRHARVtVkYDRRE PP1_inhibitor X +PRKCE PKCE Q02156 human MOR-1 18390 P42866 Oprm1 mouse S363 447783 STIEQQNsARIRQNt X +PRKCE PKCE Q02156 human SCN10A Q62968 Scn10a rat S1452 25126701 NAMKKLGsKKPQKPI X +PRKCE PKCE Q02156 human NSF P18708 NSF hamster S460 15794301 MNRHIKAstKVEVDM AAA_lid_3 X +PRKCE PKCE Q02156 human MCU 90550 Q8NE86 MCU human S92 27259017 VISVRLPsRRERCQF X +PRKCE PKCE Q02156 human EGFR 1956 P00533 EGFR human T678 448053 RHIVRKRtLRRLLQE X 14343 +PRKCE PKCE Q02156 human AID 11628 Q9WVE0 Aicda mouse S3 20660600 _____MDsLLMKQKK X +PRKCE PKCE Q02156 human CACNA1C 100101555 P15381 CACB rabbit S533 453091 RIsKSKFsRYWRRWN X +PRKCE PKCE Q02156 human SLC6A2 6530 P23975 SLC6A2 human S259 465614 LWKGVKtsGKVVWIT SNF X +PRKCE PKCE Q02156 human MIIP 60672 Q5JXC2 MIIP human S303 4170074 YHIHRRKsFDASDTL MIIP X X +PRKCE PKCE Q02156 human PLM 476487 P56513 FXYD1 dog S83 451424 EEGTFRSsIRRLstR X +PRKCE PKCE Q02156 human KEAP1 9817 Q14145 KEAP1 human S599 29606702 SEVTRMTsGRsGVGV X +PRKCE PKCE Q02156 human GJA1 24392 P08050 Gja1 rat S372 465460 sRAssRAssRPRPDD X +PRKCE PKCE Q02156 human CENTA1 11033 O75689 ADAP1 human S87 11380900 AARARFEsKVPSFYY ArfGap X +PRKCE PKCE Q02156 human IRS1 16367 P35569 Irs1 mouse S318 451399 MVGGKPGsFRVRASs X 5610 +PRKCE PKCE Q02156 human Tau iso8 4137 P10636-8 MAPT human S324 449328 kVtskCGsLGNIHHk Tubulin-binding X +PRKCE PKCE Q02156 human AurB 9212 Q96GD4 AURKB human S227 4271812 GWSVHAPsLRRktMC Pkinase X X +PRKCE PKCE Q02156 human PLM 476487 P56513 FXYD1 dog S88 451425 RSsIRRLstRRR___ X +PRKCE PKCE Q02156 human PKCE 5581 Q02156 PRKCE human S234 479975 EtPDQVGsQRFSVNM X +PRKCE PKCE Q02156 human TNNT2 24837 P50753 Tnnt2 rat S209 451755 kAQtERKsGKRQtER Troponin X +PRKCE PKCE Q02156 human SLC24A2 84550 O54701 Slc24a2 rat T166 471069 VPSLTVItEKLGISD Na_Ca_ex X +PRKCE PKCE Q02156 human CHAT iso3 1103 P28329-3 CHAT human S440 449057 VPTYESAsIRRFQEG Carn_acyltransf X +PRKCE PKCE Q02156 human GJA1 24392 P08050 Gja1 rat S365 459207 IVDQRPssRAssRAs X +PRKCE PKCE Q02156 human ITGB1 3688 P05556 ITGB1 human T789 447709 IyksAVttVVNPkyE Integrin_b_cyt X +PRKCE PKCE Q02156 human STAT3 6774 P40763 STAT3 human S727 448191 NtIDLPMsPrTLDSL X 9134; 9136; 34911; 94994; 49081; 58978; 87544; 71958; 50804 +PRKCE PKCE Q02156 human TNNI3 511094 P08057 TNNI3 cow S46 450691 KKSKIsAsRKLQLKT X +PRKCE PKCE Q02156 human TNNI3 7137 P19429 TNNI3 human S44 450691 KKskIsAsRKLQLKt X +PRKCE PKCE Q02156 human NSF P18708 NSF hamster T461 15794300 NRHIKAstKVEVDME AAA_lid_3 X +PRKCE PKCE Q02156 human P311 9315 Q16612 NREP human S59 457551 LGSSELRsPRISYLH Alveol-reg_P311 X +PRKCE PKCE Q02156 human ZO2 403854 Q95168 TJP2 dog S369 9730701 QLVVLRDsKQTLINI X X +PRKCE PKCE Q02156 human PKCE 5581 Q02156 PRKCE human K534 1870790710 GVIYRDLkLDNILLD Pkinase X +PRKCE PKCE Q02156 human TNNT2 286816 P13789 TNNT2 cow T200 451556 RKsGKRQtEREKKKK Troponin X +PRKCE PKCE Q02156 human Tau iso8 4137 P10636-8 MAPT human S293 449327 NVQskCGsKDNIkHV Tubulin-binding X +PRKCE PKCE Q02156 human BAD 572 Q92934 BAD human S99 447862 PFrGrsRsAPPNLWA Bcl-2_BAD X 9295; 5286; 4366 +PRKCE PKCE Q02156 human TNNI3 511094 P08057 TNNI3 cow S79 451839 GEKGRALsTRCQPLE Troponin X +PRKCE PKCE Q02156 human ALDH2 217 P05091 ALDH2 human T429 62906102 MQILkFKtIEEVVGR Aldedh X +PRKCE PKCE Q02156 human PRKD2 25865 Q9BZL6 PRKD2 human S706 449864 ARIIGEksFRRsVVG Pkinase X +PRKCE PKCE Q02156 human PRKD2 25865 Q9BZL6 PRKD2 human S710 449865 GEksFRRsVVGtPAy Pkinase X +PRKCE PKCE Q02156 human occludin 100506658 Q16625 OCLN human T404 471472 HyEtDyttGGEsCDE X X +PRKCE PKCE Q02156 human KCNK3 3777 O14649 KCNK3 human T383 2840502 TGLHSLStFRGLMKR X X +PRKCE PKCE Q02156 human ephexin-5 442801 Q5FWH6 Arhgef15 mouse S107 17546056 PSPVSRRsIsPEPAP X X +PRKCE PKCE Q02156 human FGFR1 2260 P11362 FGFR1 human S779 27930809 PLDQysPsFPDTRSS X X +PRKCE PKCE Q02156 human TRPV1 7442 Q8NER1 TRPV1 human S801 450017 VPLLREAsARDRQsA X +PRKCE PKCE Q02156 human TICAM2 353376 Q86XR7 TICAM2 human S16 465617 NSCPLsLsWGKRHsV X X +PRKCE PKCE Q02156 human NANOG 79923 Q9H9S0 NANOG human T78 28070706 sPKGKQPtsAEKSVA X +PRKCE PKCE Q02156 human BAD 572 Q92934 BAD human S75 447860 EIRsRHssyPAGtED Bcl-2_BAD X X 9291; 5284; 9296; 5193; 11865; 94223 +PRKCE PKCE Q02156 human CACNA1B 257648 Q02294 Cacna1b rat S1757 465548 FEMLKHMsPPLGLGK GPHH X +PRKCE PKCE Q02156 human Tau iso8 4137 P10636-8 MAPT human S258 487453 PDLkNVKskIGstEN Tubulin-binding X +PRKCE PKCE Q02156 human CREB 1385 P16220 CREB1 human S119 448228 EILsRRPsyRkILND pKID X 9187; 9196; 9198; 4095; 14228; 14001; 39561; 80120; 44864; 54960; 95995 +PRKCE PKCE Q02156 human KIR3DL1 3811 P43629 KIR3DL1 human S415 990302 QRKITRPsQRPKtPP X +PRKCE PKCE Q02156 human XIAP 331 P98170 XIAP human S87 450336 VGRHRKVsPNCRFIN BIR X +PRKCE PKCE Q02156 human CACNA1B 257648 Q02294 Cacna1b rat S2132 465550 YsCDRFGsREPPQPK X +PRKCE PKCE Q02156 human P70S6KB 6199 Q9UBS0 RPS6KB2 human S473 450071 PPSGTKKsKRGRGRP X X +PRKCE PKCE Q02156 human K18 3875 P05783 KRT18 human S53 447734 IsVsrstsFrGGMGs X +PRKCE PKCE Q02156 human G-alpha i2 2771 P04899 GNAI2 human S44 12575205 LLLGAGEsGkSTIVk G-alpha X +PRKCE PKCE Q02156 human K8 16691 P11679 Krt8 mouse S24 448538 PrAFssRsFtsGPGA Keratin_2_head X +PRKCE PKCE Q02156 human PKCE 5581 Q02156 PRKCE human S729 448789 QEEFKGFsYFGEDLM Pkinase_C X X 9371 +PRKCE PKCE Q02156 human SLC24A2 84550 O54701 Slc24a2 rat T476 471067 SLSWPSNtRKQITFL X +PRKCE PKCE Q02156 human GJA1 24392 P08050 Gja1 rat S368 447813 QRPssRAssRAssRP X 3511; 52559 +PRKCE PKCE Q02156 human BAD 572 Q92934 BAD human S118 447863 GRELRRMsDEFVDsF Bcl-2_BAD X 9297 +PRKCE PKCE Q02156 human TET1 80312 Q8NFU7 TET1 human T1164 1881549500 DRRKkKPtVVSYQEN X X +PRKCE PKCE Q02156 human glutaminase iso3 2744 O94925-3 GLS human S314 937769500 RYVGKEPsGLRFNKL Glutaminase X X +PRKCE PKCE Q02156 human TNNI3 511094 P08057 TNNI3 cow T145 451483 RGKFKRPtLRRVRIS Troponin X +PRKCE PKCE Q02156 human IQGAP1 8826 P46940 IQGAP1 human S1443 454416 DKMKKsksVkEDsNL X X +PRKCE PKCE Q02156 human ALDH2 217 P05091 ALDH2 human T202 62906103 KLGPALAtGNVVVMK Aldedh X +PRKCE PKCE Q02156 human CACNA1C 100101555 P15381 CACB rabbit S528 486358 ARLAHRIsKSKFsRY X +PRKCE PKCE Q02156 human PRKD1 5587 Q15139 PRKD1 human S738 448589 ARIIGEksFRRsVVG Pkinase X 2054 +PRKCE PKCE Q02156 human coronin 1B 57175 Q9BR76 CORO1B human S2 456131 ______MsFRKVVRQ X +PRKCE PKCE Q02156 human GJA1 24392 P08050 Gja1 rat S369 459208 RPssRAssRAssRPR X +PRKCE PKCE Q02156 human RAB11A 8766 P62491 RAB11A human S177 22826101 TEIYRIVsQkQMSDR X +PRKCE PKCE Q02156 human RAB5A 5868 P20339 RAB5A human T7 33622402 _MAsrGAtRPNGPNT X +PRKCE PKCE Q02156 human NANOG 79923 Q9H9S0 NANOG human T280 28070709 GLNVIQQtTRYFStP X X +PRKCE PKCE Q02156 human MYBPC3 17868 O70468 Mybpc3 mouse S302 471081 sLLKKRDsFRRDskL X X +PRKCE PKCE Q02156 human ITGB1 3688 P05556 ITGB1 human T788 448600 PIyksAVttVVNPky Integrin_b_cyt X +PRKCE PKCE Q02156 human KCNK3 E2RAI2 KCNK3 dog T373 2840502 TGLHSLStFRGLMKR X +PRKCE PKCE Q02156 human CHAT iso3 1103 P28329-3 CHAT human S476 454037 HKAAVPAsEKLLLLK Carn_acyltransf X +PRKCE PKCE Q02156 human CACNA1B 257648 Q02294 Cacna1b rat S425 465547 KRAAtKKsRNDLIHA X +PRKCE PKCE Q02156 human GJA1 2697 P17302 GJA1 human S368 447813 QRPssRAssRAssRP X X 3511; 52559 +PRKCE PKCE Q02156 human ephexin-5 442801 Q5FWH6 Arhgef15 mouse S109 17546059 PVSRRsIsPEPAPCS X X +PRKCE PKCE Q02156 human TNNT2 286816 P13789 TNNT2 cow T281 451557 TRGKAKVtGRWK___ X +PRKCE PKCE Q02156 human CACNA1D 29716 P27732 Cacna1d rat S81 470135 PPPVGSLsQRKRQQY X +PRKCE PKCE Q02156 human K8 16691 P11679 Krt8 mouse S47 484005 RVGsssssFRGSMGT Keratin_2_head X +PRKCE PKCE Q02156 human PRKD2 25865 Q9BZL6 PRKD2 human S876 448800 QGLAERIsVL_____ X +PRKCE PKCE Q02156 human CACNA1B 257648 Q02294 Cacna1b rat T422 465546 AVLKRAAtKKsRNDL X +PRKCE PKCE Q02156 human PLM 476487 P56513 FXYD1 dog T89 455220 SsIRRLstRRR____ X +PRKCE PKCE Q02156 human IKKB 3551 O14920 IKBKB human S177 447492 AkELDQGsLCtsFVG Pkinase X X 2078; 2697; 2694; 14938; 92255; 36516; 36214 +PRKCE PKCE Q02156 human TNNT2 21956 P50752 Tnnt2 mouse S211 451755 QAQtERKsGKRQtER Troponin X +PRKCE PKCE Q02156 human ALDH2 217 P05091 ALDH2 human S296 62906101 KSPNIIMsDADMDWA Aldedh X +PRKCE PKCE Q02156 human GABRG2 29709 Q6PW52 Gabrg2 rat S365 486436 FVSNRKPsKDKDKKK Neur_chan_memb X +PRKCE PKCE Q02156 human occludin 100506658 Q16625 OCLN human T403 471471 DHyEtDyttGGEsCD X X +PRKCE PKCE Q02156 human PKCE 5581 Q02156 PRKCE human S368 2085101 NNIRKALsFDNRGEE X +PRKCE PKCE Q02156 human ATF-2 1386 P15336 ATF2 human T52 23305000 HkHKHEMtLKFGPAR X X +PRKCE PKCE Q02156 human GJA1 24392 P08050 Gja1 rat S373 459209 RAssRAssRPRPDDL X +PRKCE PKCE Q02156 human PRKD1 5587 Q15139 PRKD1 human S742 448590 GEksFRRsVVGtPAy Pkinase X +PRKCE PKCE Q02156 human CTNND1 1500 O60716 CTNND1 human S268 450453 PQVRVGGssVDLHRF X X +PRKCE PKCE Q02156 human Met 4233 P08581 MET human S985 450188 PHLDRLVsARsVsPt X +Csnk2a1 CK2A1 P19139 rat PAR-4 64513 Q62627 Pawr rat S223 476476 GRYKSTIsAPEEEIL ATG16 X X +Csnk2a1 CK2A1 P19139 rat BAD 12015 Q61337 Bad mouse T117 454387 HssyPAGtEEDEGME Bcl-2_BAD X +Csnk2a1 CK2A1 P19139 rat TCF4 6925 P15884 TCF4 human S55 451215 SNVEDRsssGSWGNG X +Csnk2a1 CK2A1 P19139 rat RIC8A 293614 Q80ZG1 Ric8a rat S435 468627 GRPEGQYsEDEDtDT Ric8 X +Csnk2a1 CK2A1 P19139 rat NFAT2 4772 O95644 NFATC1 human S187 465578 RSCNsEAsSYESNYS X +Csnk2a1 CK2A1 P19139 rat SSB 6741 P05455 SSB human S366 449301 GkktKFAsDDEHDEH X +Csnk2a1 CK2A1 P19139 rat DEK 7913 P35659 DEK human S301 465703 QNsSKKEsEsEDssD X +Csnk2a1 CK2A1 P19139 rat PAM 25508 P14925 Pam rat T946 455820 KGFDRVstEGsDQEK X +Csnk2a1 CK2A1 P19139 rat GAP43 29423 P07936 Gap43 rat T88 449599 kEGDGsAttDAAPAt Neuromodulin X +Csnk2a1 CK2A1 P19139 rat NCAM-L1 50687 Q05695 L1cam rat S1183 465573 GEyRsLEsDNEEKAF Bravo_FIGEY X +Csnk2a1 CK2A1 P19139 rat GAP43 29423 P07936 Gap43 rat T95 449601 ttDAAPAtsPKAEEP Neuromodulin X +Csnk2a1 CK2A1 P19139 rat Calmodulin 801 P0DP23 CALM3 human S82 448705 RkMkDtDsEEEIrEA X +Csnk2a1 CK2A1 P19139 rat eIF2B-epsilon 192234 Q64350 Eif2b5 rat S712 449907 LREAEEEssDDD___ W2 X +Csnk2a1 CK2A1 P19139 rat PAR-4 64513 Q62627 Pawr rat S124 28030293 GDEEEPDsAPEKGRS X X +Csnk2a1 CK2A1 P19139 rat p53 22059 P02340 Tp53 mouse S389 447535 VkkVGPDsD______ X 9281 +Csnk2a1 CK2A1 P19139 rat PTMA 786336 P01252 PTMA cow T13 459125 VDtSSEIttKDLKEK Prothymosin X +Csnk2a1 CK2A1 P19139 rat TCF4 6925 P15884 TCF4 human S54 451214 GSNVEDRsssGSWGN X +Csnk2a1 CK2A1 P19139 rat EGR1 1958 P18146 EGR1 human S378 11421601 RICMRNFsRSDHLTT zf-C2H2 X +Csnk2a1 CK2A1 P19139 rat calsequestrin 2 483134 P12637 CASQ2 dog S397 451464 DDDDGNNsDEEsNDD X X +Csnk2a1 CK2A1 P19139 rat GAP43 29423 P07936 Gap43 rat S96 449105 tDAAPAtsPKAEEPS Neuromodulin X +Csnk2a1 CK2A1 P19139 rat YY1 24919 Q8CHJ4 Yy1 rat S117 460025 EVVGGDDsDGLRAED X +Csnk2a1 CK2A1 P19139 rat Calmodulin 801 P0DP23 CALM3 human T80 448704 MARkMkDtDsEEEIr X +Csnk2a1 CK2A1 P19139 rat MAX 60661 P52164 Max rat S11 449308 NDDIEVEsDEEQPRF X +Csnk2a1 CK2A1 P19139 rat GAP43 29423 P07936 Gap43 rat S192 449598 PTETAEssQAEEEkE Neuromodulin X +Csnk2a1 CK2A1 P19139 rat EGR1 1958 P18146 EGR1 human S301 11423702 AFATQSGsQDLKALN X +Csnk2a1 CK2A1 P19139 rat SLK 9748 Q9H2G2 SLK human S347 466943 ssDLsIAssEEDKLs X +Csnk2a1 CK2A1 P19139 rat TNNT3 100009527 P02641 TNNT3 rabbit S2 466430 ______MsDEEVEHV X +Csnk2a1 CK2A1 P19139 rat PTMA 786336 P01252 PTMA cow T14 459126 DtSSEIttKDLKEKK Prothymosin X +Csnk2a1 CK2A1 P19139 rat TUBB3 246118 Q4QRB4 Tubb3 rat S444 451154 YEDDDEEsEAQGPK_ X +Csnk2a1 CK2A1 P19139 rat eIF2-beta 100009285 P41035 EIF2S2 rabbit S67 450072 DSRKKDAsDDLDDLN X +Csnk2a1 CK2A1 P19139 rat HMGA1 3159 P17096 HMGA1 human S102 452254 EEGIsQEssEEEQ__ X +Csnk2a1 CK2A1 P19139 rat SLK 9748 Q9H2G2 SLK human S348 466944 sDLsIAssEEDKLsQ X +Csnk2a1 CK2A1 P19139 rat CDC37 114562 Q63692 Cdc37 rat S13 450034 VWDHIEVsDDEDETH CDC37_N X X 13248 +Csnk2a1 CK2A1 P19139 rat DEK 7913 P35659 DEK human S244 476134 KKNKEEssDDEDKEs X +Csnk2a1 CK2A1 P19139 rat DEK 7913 P35659 DEK human S306 465705 KEsEsEDssDDEPLI X +Csnk2a1 CK2A1 P19139 rat Jun 24516 P17325 Jun rat S63 447686 KNSDLLtsPDVGLLK Jun X 5464; 9261; 2361; 97721; 91952 +Csnk2a1 CK2A1 P19139 rat EGR1 1958 P18146 EGR1 human S196 11423701 PLSCAVPsNDSSPIY DUF3446 X +Csnk2a1 CK2A1 P19139 rat PSMA3 29670 P18422 Psma3 rat S243 451184 AEkyAKEsLKEEDEs X +Csnk2a1 CK2A1 P19139 rat p70S6K 83840 P67999 Rps6kb1 rat S40 450117 DQPEDAGsEDELEEG X +Csnk2a1 CK2A1 P19139 rat ODC 18263 P00860 Odc1 mouse S303 451283 VWKEQPGsDDEDESN Orn_DAP_Arg_deC X +Csnk2a1 CK2A1 P19139 rat DEK 7913 P35659 DEK human S32 465616 MPGPREEsEEEEDED X +Csnk2a1 CK2A1 P19139 rat PTMA 786336 P01252 PTMA cow T8 459124 MSDAAVDtSSEIttK Prothymosin X +Csnk2a1 CK2A1 P19139 rat SP1 24790 Q01714 Sp1 rat T669 452043 SYCGKRFtRsDELQR zf-C2H2 X +Csnk2a1 CK2A1 P19139 rat MAX 60661 P52164 Max rat S2 449307 ______MsDNDDIEV X +Csnk2a1 CK2A1 P19139 rat Calmodulin 24242 P0DP29 Calm3 rat S102 448706 kDGNGyIsAAELRHV EF-hand_7 X +Csnk2a1 CK2A1 P19139 rat EGR1 1958 P18146 EGR1 human S104 11423700 YEHLTAEsFPDISLN X +Csnk2a1 CK2A1 P19139 rat CPT1A 25757 P32198 Cpt1a rat S747 479871 FsSPETDsHRFGKHL Carn_acyltransf X +Csnk2a1 CK2A1 P19139 rat DEK 7913 P35659 DEK human S303 465704 sSKKEsEsEDssDDE X +Csnk2a1 CK2A1 P19139 rat Calmodulin 801 P0DP23 CALM3 human S102 448706 kDGNGyIsAAELrHV EF-hand_7 X +Csnk2a1 CK2A1 P19139 rat p70S6K iso2 83840 P67999-2 Rps6kb1 rat S17 450117 DQPEDAGsEDELEEG X +Csnk2a1 CK2A1 P19139 rat calsequestrin 1 100009095 P07221 CASQ1 rabbit T381 451337 VLEGEINtEDDDDED Calsequestrin X +Csnk2a1 CK2A1 P19139 rat ACC1 60581 P11497 Acaca rat S29 448771 GsVsEDNsEDEIsNL X +Csnk2a1 CK2A1 P19139 rat Calmodulin 24242 P0DP29 Calm3 rat T80 448704 MARKMkDtDsEEEIR X +Csnk2a1 CK2A1 P19139 rat PAR-4 5074 Q96IZ0 PAWR human S231 476476 GRyksttsVsEEDVS X +Csnk2a1 CK2A1 P19139 rat calsequestrin 2 483134 P12637 CASQ2 dog S405 1868253001 DEEsNDDsDDDDE__ X X +Csnk2a1 CK2A1 P19139 rat RIC8A 293614 Q80ZG1 Ric8a rat T440 468628 QYsEDEDtDTEEYRE Ric8 X +Csnk2a1 CK2A1 P19139 rat TAGLN 25123 P31232 Tagln rat T139 18016558 ALGSLAVtKNDGHYR CH X +Csnk2a1 CK2A1 P19139 rat eIF2-beta 100009285 P41035 EIF2S2 rabbit S2 451805 ______MsGDEMIFD X +Csnk2a1 CK2A1 P19139 rat EGR1 1958 P18146 EGR1 human T148 11423703 PAPNSGNtLWPEPLF DUF3446 X +Csnk2a1 CK2A1 P19139 rat STX1A 116470 P32851 Stx1a rat S14 451261 ELRTAKDsDDDDDVt X X +Csnk2a1 CK2A1 P19139 rat calsequestrin 2 483134 P12637 CASQ2 dog S401 451475 GNNsDEEsNDDsDDD X X +Csnk2a1 CK2A1 P19139 rat TCF4 6925 P15884 TCF4 human S56 451216 NVEDRsssGSWGNGG X +Csnk2a1 CK2A1 P19139 rat Calmodulin 24242 P0DP29 Calm3 rat S82 448705 RKMkDtDsEEEIREA X X +Csnk2a1 CK2A1 P19139 rat PSMA3 29670 P18422 Psma3 rat S250 451185 sLKEEDEsDDDNM__ X +Csnk2a1 CK2A1 P19139 rat eIF2B-epsilon 192234 Q64350 Eif2b5 rat S713 449908 REAEEEssDDD____ W2 X +Csnk2a1 CK2A1 P19139 rat HMGA1 3159 P17096 HMGA1 human S103 452255 EGIsQEssEEEQ___ X +Csnk2a1 CK2A1 P19139 rat Jun 24516 P17325 Jun rat S73 447943 VGLLKLAsPELERLI Jun X 9164; 3270; 8752; 12714; 77955 +Csnk2a1 CK2A1 P19139 rat NMDAR2B 24410 Q00960 Grin2b rat S1480 454415 EKLssIEsDV_____ NMDAR2_C X +Csnk2a1 CK2A1 P19139 rat DEK 7913 P35659 DEK human S243 476133 EKKNKEEssDDEDKE X +Csnk2a1 CK2A1 P19139 rat ARC 85383 Q62881 Nol3 rat T149 448618 SEAVQPRtPEEPELE X +Csnk2a1 CK2A1 P19139 rat GAP43 29423 P07936 Gap43 rat T89 449600 EGDGsAttDAAPAts Neuromodulin X +Csnk2a1 CK2A1 P19139 rat Calmodulin 801 P0DP23 CALM3 human T118 469586 tNLGEkLtDEEVDEM EF-hand_7 X +Csnk2a1 CK2A1 P19139 rat GAP43 29423 P07936 Gap43 rat S191 449597 PPTETAEssQAEEEk Neuromodulin X +Csnk2a1 CK2A1 P19139 rat CPT1A 25757 P32198 Cpt1a rat S741 479870 FHISSKFsSPETDsH Carn_acyltransf X +Csnk2a1 CK2A1 P19139 rat PAM 25508 P14925 Pam rat S949 453092 DRVstEGsDQEKDED X +Csnk2a1 CK2A1 P19139 rat DEK 7913 P35659 DEK human S251 476135 sDDEDKEsEEEPPKK X +Csnk2a1 CK2A1 P19139 rat SYT1 25716 P21707 Syt1 rat T112 448549 DVKDLGKtMKDQALK X +STK3 MST2 Q13188 human GR 2908 P04150 NR3C1 human S682 1872513508 VPkDGLksQELFDEI Hormone_recep X +STK3 MST2 Q13188 human PKCA 5578 P17252 PRKCA human S226 2050181 LNPQWNEsFtFkLKP C2 X +STK3 MST2 Q13188 human Abl 25 P00519 ABL1 human T735 450291 DTEWRSVtLPRDLQS X 2864 +STK3 MST2 Q13188 human MOB1B 92597 Q7L9L4 MOB1B human T74 11555108 QINMLYGtITDFCTE Mob1_phocein X +STK3 MST2 Q13188 human SAV1 60485 Q9H4B6 SAV1 human S36 21507300 LLRNLMPsFIRHGPT X +STK3 MST2 Q13188 human GR 2908 P04150 NR3C1 human T562 1872513501 StWRIMTtLNMLGGR Hormone_recep X +STK3 MST2 Q13188 human MOB1A 55233 Q9H8S9 MOB1A human T35 3212769 LLkHAEAtLGsGNLR Mob1_phocein X 8699 +STK3 MST2 Q13188 human OBSCN 84033 Q5VST9 OBSCN human T5798 1881579400 AESVVVStAIQEFYK X +STK3 MST2 Q13188 human NEK2 4751 P51955 NEK2 human S406 26367604 NsEsQLtsksKCKDL X +STK3 MST2 Q13188 human MOB1A 55233 Q9H8S9 MOB1A human T12 34669905 FsSRssktFKPkkNI X +STK3 MST2 Q13188 human LC3B 67443 Q9CQV6 Map1lc3b mouse T50 37045604 QLPVLDktkFLVPDH ATG8 X X +STK3 MST2 Q13188 human LATS1 9113 O95835 LATS1 human S909 457594 HQRCLAHsLVGTPNY Pkinase X 9157 +STK3 MST2 Q13188 human H3 360198 P68433 H3c1 mouse S10 455676 tkQTARkstGGkAPr Histone X 9701; 9711; 9606; 3465; 3642; 3377; 3475; 3458; 5764; 47398; 8481; 8552; 53348; 29237; 66065; 43185; 64522; 52725 +STK3 MST2 Q13188 human AMPKA1 5562 Q13131 PRKAA1 human T183 448786 sDGEFLRtsCGsPNy Pkinase X 2535; 2531; 4188; 5256; 50081; 74281 +STK3 MST2 Q13188 human PKCA 5578 P17252 PRKCA human T228 3875546 PQWNEsFtFkLKPsD C2 X +STK3 MST2 Q13188 human SAV1 60485 Q9H4B6 SAV1 human S269 21507301 YRHPCAPsVPRyDQP X +STK3 MST2 Q13188 human MST2 6788 Q13188 STK3 human T378 50592100 DEEEEDGtMKRNAts X +STK3 MST2 Q13188 human SAV1 60485 Q9H4B6 SAV1 human T26 4270990 GKYVKKEtsPLLRNL X +STK3 MST2 Q13188 human GR 2908 P04150 NR3C1 human T668 1872513506 EEYLCMKtLLLLSSV Hormone_recep X +STK3 MST2 Q13188 human LATS1 9113 O95835 LATS1 human T967 1791601 MKVINWQtSLHIPPQ Pkinase X +STK3 MST2 Q13188 human YAP1 10413 P46937 YAP1 human S127 448847 PQHVRAHssPAsLQL X 4911; 13008; 92367; 57706 +STK3 MST2 Q13188 human SAV1 60485 Q9H4B6 SAV1 human S27 7447103 KYVKKEtsPLLRNLM X +STK3 MST2 Q13188 human LATS1 9113 O95835 LATS1 human T1079 457595 EHAFyEFtFRRFFDD X 8654 +STK3 MST2 Q13188 human NEK2 4751 P51955 NEK2 human S365 20721644 LkERkFLsLASNPEL X +STK3 MST2 Q13188 human STAT3 6774 P40763 STAT3 human T622 1877503800 kEGGVTFtWVEkDIS SH2 X X +STK3 MST2 Q13188 human LATS1 9113 O95835 LATS1 human T1060 1791600 EEENVNDtLNGWYKN X +STK3 MST2 Q13188 human MOB1A 55233 Q9H8S9 MOB1A human T74 2506801 QINMLYGtITEFCTE Mob1_phocein X +STK3 MST2 Q13188 human NEK2 4751 P51955 NEK2 human S356 12574602 ENLLkNYsLLkERkF X +STK3 MST2 Q13188 human GR 2908 P04150 NR3C1 human S746 1872513507 TFLDKTMsIEFPEML X +STK3 MST2 Q13188 human LC3B 81631 Q9GZQ8 MAP1LC3B human T50 37045604 QLPVLDktkFLVPDH ATG8 X X +STK3 MST2 Q13188 human MOB1B 92597 Q7L9L4 MOB1B human T35 3545001 LLkHAEAtLGsGNLR Mob1_phocein X X 8699 +STK3 MST2 Q13188 human H3 360198 P68433 H3c1 mouse S28 455677 ATkAArksAPATGGV Histone X 9713 +STK3 MST2 Q13188 human MST2 6788 Q13188 STK3 human T180 448899 DtMAkRNtVIGTPFW Pkinase X 3681; 49332 +STK3 MST2 Q13188 human QSK 23387 Q9Y2K2 SIK3 human T221 456036 TPGQLLKtWCGSPPY Pkinase X +STK3 MST2 Q13188 human LATS1 9113 O95835 LATS1 human T1012 1791603 kAHPFFKtIDFSSDL X +STK3 MST2 Q13188 human LATS1 9113 O95835 LATS1 human S872 1791604 GDHPRQDsMDFSNEW Pkinase X +STK3 MST2 Q13188 human NEK2 4751 P51955 NEK2 human S438 26367603 EkNYQLksRQILGMR X X +STK3 MST2 Q13188 human MOB1B 92597 Q7L9L4 MOB1B human T12 3545000 FGsRssktFKPkkNI X X 8843 +PKM PKM P14618 human MDM2 4193 Q00987 MDM2 human T351 17342607 kAkLENstQAEEGFD X +PKM PKM P14618 human MRLC2V 4633 P10916 MYL2 human Y118 473229 kGVLKADyVREMLtT X X +PKM PKM P14618 human SREBP-1 6720 P36956 SREBF1 human T59 900975702 AGSGAGGtDPAsPDT X +PKM PKM P14618 human STAT3 6774 P40763 STAT3 human Y705 448192 DPGsAAPyLktKFIC X X 4093; 9145; 4324; 9131; 9138; 4323; 4074; 4113; 48313; 20977; 25023; 8119; 52075; 52527; 73533; 61958; 73452; 16185; 74309 +PKM PKM P14618 human CtIP 5932 Q99708 RBBP8 human T126 1275585105 ELMNERNtLQEENKK CtIP_N X X +PKM PKM P14618 human MDM2 4193 Q00987 MDM2 human S166 448130 SsRRRAIsEtEENsD X 3521 +PKM PKM P14618 human PRAS40 84335 Q96B36 AKT1S1 human S203 454572 KRtEARssDEENGPP PRAS X X +PKM PKM P14618 human PRAS40 84335 Q96B36 AKT1S1 human S202 454571 EKRtEARssDEENGP PRAS X X +PKM PKM P14618 human SNAP23 8773 O00161 SNAP23 human S95 455262 NRTkNFEsGkAykTt SNAP-25 X X +TTN Titin Q8WZ42 human Telethonin 21393 O70548 Tcap mouse S157 448693 GPLRRtLsRsMsQEA Telethonin X +AK2 AK2 P54819 human LOXL3 84695 P58215 LOXL3 human S704 1881957100 PNFEVAEsDFTNNAM X +Pak5 PAK5 Q8C015 mouse BAD 12015 Q61337 Bad mouse S112 447860 ETRsRHssyPAGtEE Bcl-2_BAD X X 9291; 5284; 9296; 5193; 11865; 94223 +Prkd2 PRKD2 Q8BZ03 mouse PRKD2 101540 Q8BZ03 Prkd2 mouse S873 448800 QGLAERIsIL_____ X +Prkd2 PRKD2 Q8BZ03 mouse PRKD1 18760 Q62101 Prkd1 mouse S916 447632 KALSERVsIL_____ X 2051; 75148 +AATK Lmr1 Q6ZMQ8 human p53 7157 P04637 TP53 human S366 455223 PGGsRAHssHLkskk X X +Epha4 EphA4 Q03137 mouse EphA4 13838 Q03137 Epha4 mouse Y779 450858 EDDPEAAyttRGGKI PK_Tyr_Ser-Thr X 8793; 8862 +Epha4 EphA4 Q03137 mouse EphA4 13838 Q03137 Epha4 mouse Y928 450651 QAIKMDRyKDNFTAA SAM_2 X +Dyrk1a DYRK1A Q63470 rat Tau iso8 4137 P10636-8 MAPT human T231 449079 KKVAVVRtPPKsPss X 20473; 71429 +Dyrk1a DYRK1A Q63470 rat Tau iso8 4137 P10636-8 MAPT human S199 447927 GDRsGyssPGsPGtP X 29957 +Dyrk1a DYRK1A Q63470 rat DYRK1A 25255 Q63470 Dyrk1a rat Y321 448553 LGQRIyQyIQsRFYR Pkinase X X +Dyrk1a DYRK1A Q63470 rat Tau iso8 4137 P10636-8 MAPT human S396 449081 GAEIVyKsPVVsGDt X 9632 +Dyrk1a DYRK1A Q63470 rat Tau iso8 4137 P10636-8 MAPT human S404 449082 PVVsGDtsPRHLsNV X 35834; 20194; 98523; 91600; 49562 +Dyrk1a DYRK1A Q63470 rat N-WASP 682507 O08816 Wasl rat T259 23003804 IyDFIEKtGGVEAVK X +Dyrk1a DYRK1A Q63470 rat DYRK1A 25255 Q63470 Dyrk1a rat Y219 2869605 KHDTEMKyYIVHLKR Pkinase X +Dyrk1a DYRK1A Q63470 rat DYN1 140694 P21575 Dnm1 rat S795 447604 VPPARPGsRGPAPGP X +Dyrk1a DYRK1A Q63470 rat Tau iso8 4137 P10636-8 MAPT human S202 447928 sGyssPGsPGtPGsR X 39357; 30505 +Dyrk1a DYRK1A Q63470 rat N-WASP 682507 O08816 Wasl rat T202 23003803 LtKADIGtPSNFQHI PBD X +Dyrk1a DYRK1A Q63470 rat H3F3A 3020 P84243 H3-3A human T45 18545304 PHryrPGtVALrEIR Histone X +Dyrk1a DYRK1A Q63470 rat Tau iso8 4137 P10636-8 MAPT human T217 449078 sRtPsLPtPPtREPK X 33134; 51625 +Dyrk1a DYRK1A Q63470 rat N-WASP 682507 O08816 Wasl rat T196 23003801 KAKKKRLtKADIGtP X +Dyrk1a DYRK1A Q63470 rat Tau iso8 4137 P10636-8 MAPT human T181 447932 ktPPAPktPPssGEP X 12885; 66224; 62672 +Dyrk1a DYRK1A Q63470 rat Tau iso8 4137 P10636-8 MAPT human T212 447934 tPGsRsRtPsLPtPP X +Dyrk1a DYRK1A Q63470 rat Tau iso8 4137 P10636-8 MAPT human T205 447933 ssPGsPGtPGsRsRt X 25377; 43964; 53001; 49561; 20060; 33032; 30505; 20739; 98160 +Dyrk1a DYRK1A Q63470 rat Tau iso8 4137 P10636-8 MAPT human S422 449083 GsIDMVDsPQLAtLA X +BLVRA BVR P53004 human BVR 644 P53004 BLVRA human Y83 455762 ESSSHEDyIRQFLNA GFO_IDH_MocA X +BLVRA BVR P53004 human BVR 644 P53004 BLVRA human Y72 455761 SQEVEVAyICSESSS GFO_IDH_MocA X +BLVRA BVR P53004 human PKCB 5579 P05771 PRKCB human T500 447896 WDGVttktFCGtPDy Pkinase X X 9379; 2060; 38938 +ABL2 Arg P42684 human SHP-2 19247 P35235 Ptpn11 mouse Y279 474206 ENKNKNRyKNILPFD Y_phosphatase X +ABL2 Arg P42684 human Catalase 847 P04040 CAT human Y231 450444 NANGEAVyCkFHYkT Catalase X X +ABL2 Arg P42684 human Catalase 12359 P24270 Cat mouse Y386 450445 yRARVANyQRDGPMC Catalase X +ABL2 Arg P42684 human HRas 3265 P01112 HRAS human Y137 41198101 AQDLARSyGIPYIEt Ras X +ABL2 Arg P42684 human CRK 1398 P46108 CRK human Y221 447951 GGPEPGPyAQPsVNt X 3491 +ABL2 Arg P42684 human Rin1 225870 Q921Q7 Rin1 mouse Y35 450778 KPstDPLyDTPDTRG X +ABL2 Arg P42684 human Tau iso8 4137 P10636-8 MAPT human Y310 464352 GGsVQIVykPVDLsk Tubulin-binding X +ABL2 Arg P42684 human Arg 27 P42684 ABL2 human Y439 447923 RLMtGDtytAHAGAk PK_Tyr_Ser-Thr X +ABL2 Arg P42684 human IkB-beta 81525 Q9JIA3 Nfkbib rat Y161 457691 PRDASDTyLTQSQDH X +ABL2 Arg P42684 human PDGFRB 5159 P09619 PDGFRB human Y686 7437801 IITEyCRyGDLVDyL PK_Tyr_Ser-Thr X +ABL2 Arg P42684 human GPX1 2876 P07203 GPX1 human Y98 455673 EILNSLkyVRPGGGF GSHPx X X +ABL2 Arg P42684 human MICAL2 9645 O94851 MICAL2 human Y463 1875329208 INkNFEQyTLDPGTR X X +ABL2 Arg P42684 human galectin-3 3958 P17931 LGALS3 human Y79 13213701 GAPAPGVyPGPPSGP X X +ABL2 Arg P42684 human Catalase 12359 P24270 Cat mouse Y231 450444 NADGEAVyCkFHYkT Catalase X +ABL2 Arg P42684 human MICAL2 9645 O94851 MICAL2 human Y488 1875329204 PHQVKHLyITKELEH X X +ABL2 Arg P42684 human Arg 27 P42684 ABL2 human Y261 455657 GLVTTLHyPAPKCNK X +ABL2 Arg P42684 human C/EBP-beta 1051 P17676 CEBPB human Y78 9397201 RAIDFsPyLEPLGAP X +ABL2 Arg P42684 human IRF3 3661 Q14653 IRF3 human Y292 1867930600 rLGHCHTyWAVSEEL IRF-3 X +ABL2 Arg P42684 human CRK 417553 Q04929 CRK chicken Y222 447951 GGPEPGPyAQPSINT X +ABL2 Arg P42684 human Catalase 847 P04040 CAT human Y386 450445 yRARVANyQRDGPMC Catalase X X +ABL2 Arg P42684 human PSMA7 5688 O14818 PSMA7 human Y153 456317 QTDPsGtyHAWkANA Proteasome X X +ABL2 Arg P42684 human galectin-3 3958 P17931 LGALS3 human Y118 13213700 AGPLIVPyNLPLPGG Gal-bind_lectin X X +ABL2 Arg P42684 human Tau iso8 4137 P10636-8 MAPT human Y394 487463 DHGAEIVyKsPVVsG X +ABL2 Arg P42684 human SHP-2 19247 P35235 Ptpn11 mouse Y63 455054 IQNTGDyyDLyGGEK SH2 X +ABL2 Arg P42684 human TAZ 25937 Q9GZV5 WWTR1 human Y321 27138200 sGLGLGCySVPTtPE X +ABL2 Arg P42684 human Tau iso8 4137 P10636-8 MAPT human Y197 464351 KsGDRsGyssPGsPG X +ABL2 Arg P42684 human ITGB1 3688 P05556 ITGB1 human Y783 447710 DtGENPIyksAVttV Integrin_b_cyt X X +ABL2 Arg P42684 human Siva 10572 O15304 SIVA1 human Y34 448080 RGVCAERySQEVFEk Siva X X +ABL2 Arg P42684 human MICAL2 9645 O94851 MICAL2 human Y445 1875329206 LAERESLyRLLPQTT X X +ABL2 Arg P42684 human SHP-2 19247 P35235 Ptpn11 mouse Y580 448493 REDsARVyENVGLMQ X X 3703; 5431; 13328 +ATR ATR Q13535 human PARP1 142 P09874 PARP1 human S179 481744 FRPEYsAsQLkGFsL zf-PARP X X +ATR ATR Q13535 human CtIP 5932 Q99708 RBBP8 human T859 27427901 WEVGFPStQTCMERG SAE2 X X +ATR ATR Q13535 human ATRIP 84126 Q8WXE1 ATRIP human S68 454388 EELDTLAsQALsQCP X X +ATR ATR Q13535 human MCC 4163 P23508 MCC human S120 3624826 LRsELsQsQHEVNED X +ATR ATR Q13535 human 53BP1 7158 Q12888 TP53BP1 human T302 460977 PEPEVLstQEDLFDQ X +ATR ATR Q13535 human SIRT7 51547 Q9NRC8 SIRT7 human S134 1871979200 TLLQkGRsVsAADLS SIR2 X +ATR ATR Q13535 human SIRT7 51547 Q9NRC8 SIRT7 human S136 1871979201 LQkGRsVsAADLSEA SIR2 X +ATR ATR Q13535 human RAP80 51720 Q96RL1 UIMC1 human S205 486299 sGsWDQSsQPVFENV X +ATR ATR Q13535 human CUTL1 1523 P39880 CUX1 human S1357 477892 ADtEEPKsQGEAERE X +ATR ATR Q13535 human E2F1 1869 Q01094 E2F1 human S31 447867 ALRLLDSsQIVIISA X +ATR ATR Q13535 human p53 7157 P04637 TP53 human S37 447532 NVLsPLPsQAMDDLM TAD2 X 9289 +ATR ATR Q13535 human MDM2 4193 Q00987 MDM2 human S407 450263 SSSIIyssQEDVKEF X X +ATR ATR Q13535 human XPA 7507 P23025 XPA human S196 460698 RSLEVWGsQEALEEA X X +ATR ATR Q13535 human SP1 6667 P08047 SP1 human S101 767911 DLTATQLsQGANGWQ X +ATR ATR Q13535 human BRCA1 672 P38398 BRCA1 human S1280 767901 QVILAkAsQEHHLsE X +ATR ATR Q13535 human PSF2 51659 Q9Y248 GINS2 human S182 460800 QPLEstQsQDF____ X +ATR ATR Q13535 human MCPH1 79648 Q8NEM0 MCPH1 human S322 36125335 QKQAAGMsQETFEEk Microcephalin X +ATR ATR Q13535 human Chk1 1111 O14757 CHEK1 human S317 447833 ENVkYsssQPEPRTG X X 2344; 8191; 12302 +ATR ATR Q13535 human DBF4 10926 Q9UBU7 DBF4 human S502 23010417 FSTDNSGsQPKQKsD X X +ATR ATR Q13535 human FARSLA 2193 Q9Y285 FARSA human S301 477799 QRVkRtHsQGGyGsQ tRNA-synt_2d X +ATR ATR Q13535 human FANCD2 2177 Q9BXW9 FANCD2 human S717 453231 KDGGPVTsQESGQkL FancD2 X X +ATR ATR Q13535 human NPM1 4869 P06748 NPM1 human S125 459897 AVEEDAEsEDEEEED X +ATR ATR Q13535 human FANCD2 2177 Q9BXW9 FANCD2 human T691 470035 yGLEEYDtQDGIAIN FancD2 X X +ATR ATR Q13535 human p16-INK4A 1029 P42771 CDKN2A human S7 448829 _MEPAAGssMEPSAD X +ATR ATR Q13535 human p16-INK4A 1029 P42771 CDKN2A human S152 448832 IDAAEGPsDIPD___ X +ATR ATR Q13535 human FANCM 104806 Q8BGE5 Fancm mouse S1025 28117600 ASHSAGNsQQNLESN X +ATR ATR Q13535 human Smc1 8243 Q14683 SMC1A human S957 448697 IsQEEGssQGEDsVs SMC_N X 4805; 58052 +ATR ATR Q13535 human SFRS14 10147 Q8IX01 SUGP2 human T7 460968 _MAARRItQEtFDAV X +ATR ATR Q13535 human BRCA1 672 P38398 BRCA1 human S1524 448038 LQNRNYPsQEELIKV X 9009 +ATR ATR Q13535 human BLM 641 P54132 BLM human T99 450958 NAPAGQEtQRGGSkS BLM_N X +ATR ATR Q13535 human FANCD2 2177 Q9BXW9 FANCD2 human T596 460935 RsEsPsLtQERANLS FancD2 X +ATR ATR Q13535 human RFA2 6118 P15927 RPA2 human S72 1854604 RIGNVEIsQVTIVGI X +ATR ATR Q13535 human Artemis 64421 Q96SD1 DCLRE1C human S645 457531 NLSTNADsQsssDFE X +ATR ATR Q13535 human CREB 1385 P16220 CREB1 human S107 451811 sVDsVtDsQKRREIL pKID X X +ATR ATR Q13535 human IRS1 3667 P35568 IRS1 human S270 447566 EFRPRsKsQSssNCs X +ATR ATR Q13535 human FANCA 2175 O15360 FANCA human S1449 460787 AAPDADLsQEPHLF_ X X +ATR ATR Q13535 human MLL 4297 Q03164 KMT2A human S516 4709074 VHPPLPIsQsPENES X X +ATR ATR Q13535 human AKAP12 9590 Q02952 AKAP12 human S732 481957 TDGILAGsQEHDPGQ X +ATR ATR Q13535 human RFA2 6118 P15927 RPA2 human S174 1854605 MVLSkANsQPSAGRA RPA_C X +ATR ATR Q13535 human HUWE1 10075 Q7Z6Z7 HUWE1 human S2391 460925 DEAPsNLsQAstLQA X +ATR ATR Q13535 human NOT2 4848 Q9NZN8 CNOT2 human S101 472440 PQLNRsLsQGtQLPs X +ATR ATR Q13535 human BRCA1 672 P38398 BRCA1 human S1423 448036 AVLEQHGsQPSNSYP X X +ATR ATR Q13535 human Smc1 8243 Q14683 SMC1A human S966 448698 GEDsVsGsQRIssIy SMC_N X +ATR ATR Q13535 human PELP1 27043 Q8IZL8 PELP1 human S1033 472322 LAPEALPsQGEVERE X +ATR ATR Q13535 human RAD17 5884 O75943 RAD17 human S646 447755 ETWSLPLsQNSASEL X X 13404 +ATR ATR Q13535 human Chk1 1111 O14757 CHEK1 human S345 447834 LVQGIsFsQPtCPDH X X 2341; 2348; 12268; 76784 +ATR ATR Q13535 human MDC1 9656 Q14676 MDC1 human S513 460753 PGIHLERsQAsTtVD X +ATR ATR Q13535 human SARS 6301 P49591 SARS1 human S241 482693 MQEVAQLsQFDEELy X X +ATR ATR Q13535 human Fe65 322 O00213 APBB1 human S228 36841900 DSSWATLsQGSPSYG X +ATR ATR Q13535 human BRCA1 672 P38398 BRCA1 human S1143 767900 PMGSSHAsQVCSETP X +ATR ATR Q13535 human SMARCC2 6601 Q8TAQ2 SMARCC2 human S969 15707400 PPALPPGsQPIPPTG X +ATR ATR Q13535 human 53BP1 7158 Q12888 TP53BP1 human S176 483994 GFGVLELsQsQDVEE X +ATR ATR Q13535 human DBC-1 57805 Q8N163 CCAR2 human T454 453498 AAEAAPPtQEAQGET DBC1 X 4880 +ATR ATR Q13535 human 53BP1 7158 Q12888 TP53BP1 human S166 483993 GAEDTASsQLGFGVL X +ATR ATR Q13535 human MCM3 4172 P25205 MCM3 human S535 475983 ATDDPNFsQEDQQDT X +ATR ATR Q13535 human NBS1 4683 O60934 NBN human S343 448605 TtPGPsLsQGVsVDE X X 3001 +ATR ATR Q13535 human DNAPK 5591 P78527 PRKDC human T2609 448710 LtPMFVEtQAsQGtL DNAPKcs_CC5 X +ATR ATR Q13535 human ZDHHC13 54503 Q8IUH4 ZDHHC13 human S8 41455513 MEGPGLGsQCRNHSH X +ATR ATR Q13535 human SARS 6301 P49591 SARS1 human S101 23141783 ALANLkVsQIKKVRL Seryl_tRNA_N X X +ATR ATR Q13535 human CEP164 22897 Q9UPV0 CEP164 human S186 2201409 LGELMLPsQGLKTSA X X +ATR ATR Q13535 human p16-INK4A 1029 P42771 CDKN2A human S140 448831 AAGGTrGsNHARIDA Ank_2 X +ATR ATR Q13535 human Chk1 1111 O14757 CHEK1 human S296 447832 GFskHIQsNLDFsPV X 2349; 90178 +ATR ATR Q13535 human FANCI 55215 Q9NVI1 FANCI human S565 114809700 CsQSLSVsQVHVDVH FANCI_HD2 X +ATR ATR Q13535 human Artemis 64421 Q96SD1 DCLRE1C human S516 460660 SSTVAGGsQsPKLFS X +ATR ATR Q13535 human CTF18 63922 Q8WVB6 CHTF18 human S74 478125 PAAsVGssQGGARKR X +ATR ATR Q13535 human SRPK1 6732 Q96SB4 SRPK1 human S408 1872827400 QNGDSSTsQETDSCT X +ATR ATR Q13535 human SIRT7 209011 Q8BKJ9 Sirt7 mouse S137 1871979201 LQKGRPVsAADLSEA SIR2 X +ATR ATR Q13535 human BRCA1 672 P38398 BRCA1 human S1457 450008 SEKAVLTsQKsSEYP X +ATR ATR Q13535 human XPA 7507 P23025 XPA human S173 460697 VKkNPHHsQWGDMKL XPA_C X +ATR ATR Q13535 human KIFC1 3833 Q9BW19 KIFC1 human S26 477789 RPLIkAPsQLPLsGs X +ATR ATR Q13535 human XRCC2 7516 O43543 XRCC2 human S247 482708 FFSkQDDsQsSNQFS Rad51 X +ATR ATR Q13535 human 53BP1 7158 Q12888 TP53BP1 human S452 483996 PGSLPIPsQPQFSHD X +ATR ATR Q13535 human DNAPK 5591 P78527 PRKDC human T2647 448713 QQHDFtLtQTADGRs DNAPKcs_CC5 X +ATR ATR Q13535 human MCC 4163 P23508 MCC human S118 3624820 SELRsELsQsQHEVN X +ATR ATR Q13535 human DNAPK 5591 P78527 PRKDC human S2612 448711 MFVEtQAsQGtLQtR DNAPKcs_CC5 X +ATR ATR Q13535 human p16-INK4A 1029 P42771 CDKN2A human S8 448830 MEPAAGssMEPSADW X +ATR ATR Q13535 human FANCM 57697 Q8IYD8 FANCM human S1045 28117600 LSHSAVNsQQNLELN X +ATR ATR Q13535 human DCK 1633 P27707 DCK human S74 456305 EFEELtMsQkNGGNV dNK X 40371 +ATR ATR Q13535 human RFA2 6118 P15927 RPA2 human S33 448339 GFGsPAPsQAEkkSR X X 10148 +ATR ATR Q13535 human DBF4 10926 Q9UBU7 DBF4 human T449 23010416 DDIRQNFtQLPLHkN X X +ATR ATR Q13535 human SMARCAL1 50485 Q9NZC9 SMARCAL1 human S652 23146560 RLkSDVLsQLPAkQR SNF2-rel_dom X +ATR ATR Q13535 human PCAF 8850 Q92831 KAT2B human S264 1870426001 YWHLEAPsQRRLRsP PCAF_N X +ATR ATR Q13535 human p53 iso2 22059 Q80ZA1 Trp53 mouse S18 447490 ISLELPLsQETFSGL P53_TAD X +ATR ATR Q13535 human BLM 641 P54132 BLM human T122 450959 PKEVVCTtQNtPtVk BLM_N X +ATR ATR Q13535 human RASSF1 iso2 11186 Q9NS23-2 RASSF1 human S131 486364 EWETPDLsQAEIEQK X +ATR ATR Q13535 human RBM21 64852 Q9H6E5 TUT1 human S750 477956 HEAAQEWsQGEAGKG X +ATR ATR Q13535 human ATM 472 Q13315 ATM human S1981 448797 sLAFEEGsQSTtIss X X 4526; 5883; 13050 +ATR ATR Q13535 human USP28 57646 Q96RU2 USP28 human S714 467253 ESSTNSSsQDYSTsQ X +ATR ATR Q13535 human FANCD2 2177 Q9BXW9 FANCD2 human T608 470036 NLSDEQCtQVTSLLQ FancD2 X +ATR ATR Q13535 human Chk2 11200 O96017 CHEK2 human T68 447491 SsLEtVstQELYsIP X X 2197; 2661; 28130; 12812; 82263; 64180; 59068 +ATR ATR Q13535 human SRPK1 6732 Q96SB4 SRPK1 human T326 25724401 ENPPNKMtQEKLEEs X +ATR ATR Q13535 human ATR 545 Q13535 ATR human T1989 2226546 LCFPENEtPPEGkNM FAT X X 58014; 30632 +ATR ATR Q13535 human FANCI 55215 Q9NVI1 FANCI human S559 11952935 SLSSsQCsQSLSVsQ FANCI_HD2 X +ATR ATR Q13535 human RFA2 6118 P15927 RPA2 human T21 448340 yGGAGGYtQsPGGFG X +ATR ATR Q13535 human 53BP1 7158 Q12888 TP53BP1 human S831 452385 EPVEQdssQPsLPLV X +ATR ATR Q13535 human RAD17 5884 O75943 RAD17 human S656 447756 SASELPAsQPQPFSA X X 6981 +ATR ATR Q13535 human WRN 7486 Q14191 WRN human S1141 481875 PEKAYSSsQPVISAQ X +ATR ATR Q13535 human MCM2 4171 P49736 MCM2 human S108 456310 DVEELtAsQREAAER MCM2_N X X +ATR ATR Q13535 human DAXX 1616 Q9UER7 DAXX human S424 477893 EGPsGMAsQGCPsAS X +ATR ATR Q13535 human CtIP 225182 Q80YR6 Rbbp8 mouse T855 27427901 WEVGFPStQTCLERG SAE2 X +ATR ATR Q13535 human RFA2 6118 P15927 RPA2 human S52 1854603 HIVPCTIsQLLSATL X +ATR ATR Q13535 human Chk1 12649 O35280 Chek1 mouse S345 447834 LVQGISFsQPTCPEH X 2341; 2348; 12268; 76784 +ATR ATR Q13535 human POLH 5429 Q9Y253 POLH human S601 18330800 EMDLAHNsQSMHASS X X +ATR ATR Q13535 human DBF4 10926 Q9UBU7 DBF4 human S539 482262 GLItINSsQEHLTVQ X X +ATR ATR Q13535 human NBS1 4683 O60934 NBN human S615 460790 VPEssKIsQENEIGK X +ATR ATR Q13535 human p53 7157 P04637 TP53 human S15 447490 PsVEPPLsQEtFsDL P53_TAD X X 4030; 9235; 9284; 9286; 8695; 8514; 82530; 56979 +ATR ATR Q13535 human SUN2 25777 Q9UH99 SUN2 human S12 448844 SQRLtRysQGDDDGs X +ATR ATR Q13535 human ZSCAN5 79149 Q9BUG6 ZSCAN5A human T422 1279801 DVCQKQFtQKSYLKC zf-met X +ATR ATR Q13535 human PHF14 9678 O94880 PHF14 human S294 472334 tNDsLtLsQsKsNED X +ATR ATR Q13535 human ATRIP 84126 Q8WXE1 ATRIP human S72 454389 TLAsQALsQCPAAAR X X +ATR ATR Q13535 human CCDC82 79780 Q8N4S0 CCDC82 human S154 472592 DDQEKHLsQEDNDLN DUF4196 X +ATR ATR Q13535 human 53BP1 7158 Q12888 TP53BP1 human S178 483995 GVLELsQsQDVEENT X +ATR ATR Q13535 human SIAH1 6477 Q8IUQ4 SIAH1 human S19 2840508 GtSkCPPsQRVPALT X +ATR ATR Q13535 human EWS 2130 Q01844 EWSR1 human T79 7359501 QPPTGYTtPTAPQAY X +ATR ATR Q13535 human BORA 79866 Q6PGQ7 BORA human T501 2512943 QMDsGYNtQNCGSNI X +ATR ATR Q13535 human COPS1 2873 Q13098 GPS1 human S474 467704 ksPPREGsQGELtPA X +ATR ATR Q13535 human XRCC3 7517 O43542 XRCC3 human S225 482710 PFRCEFDsQASAPRA Rad51 X +ATR ATR Q13535 human FANCI 55215 Q9NVI1 FANCI human S556 11952934 VLGSLSSsQCsQSLS FANCI_HD2 X +ATR ATR Q13535 human USP28 57646 Q96RU2 USP28 human S67 467252 DERVkEPsQDtVATE X +ATR ATR Q13535 human VCP 7415 P55072 VCP human S784 456210 NQGGAGPsQGsGGGt X +ATR ATR Q13535 human RFA2 19891 Q62193 Rpa2 mouse S33 448339 GFGsPtPsQAEKKsR X 10148 +ATR ATR Q13535 human WDHD1 11169 O75717 WDHD1 human T826 458395 kAAELTAtQVEEEEE X +ATR ATR Q13535 human MLP 65108 P49006 MARCKSL1 human S71 454298 AIEPAPPsQGAEAKG MARCKS X +STK10 LOK O94804 human Radixin 5962 P35241 RDX human T564 448374 AGRDKyKtLRQIRQG ERM_C X X 3141; 3726; 32600 +STK10 LOK O94804 human Ezrin 7430 P15311 EZR human T567 448104 QGRDkyKtLRQIRQG ERM_C X X 3141; 3726; 32600 +STK10 LOK O94804 human PLK1 5347 P53350 PLK1 human T210 448139 YDGERKktLCGtPNy Pkinase X 4354; 5472; 9062 +STK10 LOK O94804 human Moesin 4478 P26038 MSN human T558 447706 LGRDKyKtLRQIRQG ERM_C X X 3141; 3726; 32600 +LIMK1 LIMK1 P53667 human Destrin 11034 P60981 DSTN human S3 449754 _____MAsGVQVADE X +LIMK1 LIMK1 P53667 human Cofilin-1 29271 P45592 Cfl1 rat S3 448444 _____MAsGVAVsDG X X 3313; 3311 +LIMK1 LIMK1 P53667 human Cofilin-1 1072 P23528 CFL1 human S3 448444 _____MAsGVAVsDG X X 3313; 3311 +Pdk1 PDHK1 Q8BFP9 mouse PDHA1 5160 P08559 PDHA1 human S293 448258 TYRyHGHsMsDPGVs E1_dh X 31866; 37115; 48447 +Prkcd PKCD P28867 mouse HSP27 15507 P14602 Hspb1 mouse S15 448401 FsLLrsPsWEPFRDW X X +Prkcd PKCD P28867 mouse NLRC4 268973 Q3UP24 Nlrc4 mouse S533 25784900 RPLWRQEsIQSLRNT NLRC4_HD X X +Prkcd PKCD P28867 mouse IRS1 16367 P35569 Irs1 mouse S318 451399 MVGGKPGsFRVRASs X 5610 +Prkcd PKCD P28867 mouse NRF2 18024 Q60795 Nfe2l2 mouse S40 450082 SREVFDFsQRQKDYE X +Prkcd PKCD P28867 mouse p40phox 17972 P97369 Ncf4 mouse T154 448266 LRRLRPRtRKIKGVs X 4311 +Prkcd PKCD P28867 mouse JNK1 26419 Q91Y86 Mapk8 mouse S129 464647 ELDHERMsYLLYQML Pkinase X +Prkcd PKCD P28867 mouse PKCD 18753 P28867 Prkcd mouse S643 448591 LNEKPQLsFsDKNLI Pkinase_C X 9376 +Prkcd PKCD P28867 mouse H2B 319187 P10853 H2bc15 mouse S14 449904 APAPkkGskkAVTkA Histone X 6959 +Prkcd PKCD P28867 mouse PXN 19303 Q8VI36 Pxn mouse T572 465506 LKQLNKGtFKEQNDK LIM X X +Prkcd PKCD P28867 mouse STAT3 20848 P42227 Stat3 mouse S727 448191 NtIDLPMsPRTLDSL X 9134; 9136; 34911; 94994; 49081; 58978; 87544; 71958; 50804 +Prkcd PKCD P28867 mouse p53 22059 P02340 Tp53 mouse S18 447490 IsLELPLsQEtFsGL P53_TAD X 9284; 9286; 12571; 56979 +Prkcd PKCD P28867 mouse HSP27 15507 P14602 Hspb1 mouse S86 448403 RALNRQLssGVsEIR X X 2406; 2401; 9709; 11892; 64293 +Prkcd PKCD P28867 mouse PKCG 18752 P63318 Prkcg mouse T514 451041 FPGSttRtFCGtPDy Pkinase X X 9379; 2060; 38938 +Prkcd PKCD P28867 mouse G6PD-2 14380 P97324 G6pd2 mouse T10 1869062303 EQVTLSRtQVCGILR X X +Prkcd PKCD P28867 mouse 14-3-3 zeta 22631 P63101 Ywhaz mouse S58 449833 VVGARRSsWRVVSsI 14-3-3 X X 52631 +Prkcd PKCD P28867 mouse hnRNP K 15387 P61979 Hnrnpk mouse S302 457408 GrGGrGGsrARNLPL X +Prkcd PKCD P28867 mouse 14-3-3 beta 7529 P31946 YWHAB human S60 450226 VVGARRssWRVISsI 14-3-3 X 52631 +Pdgfrb PDGFRB P05622 mouse PIK3R1 18708 P26450 Pik3r1 mouse Y508 451830 QERYSKEyIEKFKRE PI3K_P85_iSH2 X +Pdgfrb PDGFRB P05622 mouse PKCD 18753 P28867 Prkcd mouse Y332 450077 ILDNNGTyGKIWEGS X +Pdgfrb PDGFRB P05622 mouse SH2-B-beta 89817 Q62985 Sh2b1 rat Y439 448753 DRLSQGAyGGLSDRP X +Pdgfrb PDGFRB P05622 mouse PKCD 18753 P28867 Prkcd mouse Y311 447573 TTEsVGIyQGFEKKP X 2055 +Pdgfrb PDGFRB P05622 mouse PKACA 18747 P05132 Prkaca mouse Y331 15230353 DTSNFDDyEEEEIRV X +Pdgfrb PDGFRB P05622 mouse SHP-2 5781 Q06124 PTPN11 human Y542 448492 sKRkGHEytNIKysL X 3751; 94740; 15543; 64117 +Pdgfrb PDGFRB P05622 mouse PDGFRB 18596 P05622 Pdgfrb mouse Y856 447509 DIMRDSNyISkGSTF PK_Tyr_Ser-Thr X 3170 +Pdgfrb PDGFRB P05622 mouse Src 20779 P05480 Src mouse Y138 450213 TGyIPSNyVAPSDSI X X +HCK Hck P08631 human Abl 25 P00519 ABL1 human Y393 450298 RLMtGDtytAHAGAk PK_Tyr_Ser-Thr X 2865 +HCK Hck P08631 human ELMO1 9844 Q92556 ELMO1 human Y216 455872 VLNSHDLyQKVAQEI ELMO_ARM X X +HCK Hck P08631 human STAT5A 6776 P42229 STAT5A human Y694 447767 LAkAVDGyVkPQIkQ X 9365; 9356; 9359; 9351; 4322; 9314; 3939; 40284; 5387; 14603; 66740; 51879; 72712 +HCK Hck P08631 human ADAM15 8751 Q13444 ADAM15 human Y715 451223 LVMLGASyWYRARLH TM X X +HCK Hck P08631 human ELMO1 9844 Q92556 ELMO1 human Y18 455871 AIEWPGAyPkLMEID X X +HCK Hck P08631 human RAPGEF1 2889 Q13905 RAPGEF1 human Y504 448393 APIPSVPyAPFAAIL X X +HCK Hck P08631 human p73 7161 O15350 TP73 human Y28 482867 SLEPDStyFDLPQSS X +HCK Hck P08631 human Abl 25 P00519 ABL1 human Y128 459259 SLEKHSWyHGPVSRN SH2 X +HCK Hck P08631 human 5-LO 240 P09917 ALOX5 human Y95 4113150 LKTPHGDyIEFPCyR PLAT X +HCK Hck P08631 human Abl 11350 P00520 Abl1 mouse Y393 450298 RLMTGDTytAHAGAK PK_Tyr_Ser-Thr X 2865 +HCK Hck P08631 human Abl 25 P00519 ABL1 human Y226 450303 KRNKPtVyGVsPNyD X 2868; 2861 +HCK Hck P08631 human Abl 25 P00519 ABL1 human Y115 450305 QGWVPsNyItPVNSL X +HCK Hck P08631 human Abl 25 P00519 ABL1 human Y215 469589 GLITTLHyPAPKRNK X +HCK Hck P08631 human Abl 25 P00519 ABL1 human Y70 462900 PNLFVALyDFVAsGD SH3_1 X 3098 +HCK Hck P08631 human TBK1 29110 Q9UHD2 TBK1 human Y354 3437786 SSNQELIyEGRRLVL TBK1_ULD X +HCK Hck P08631 human Arg 11352 Q4JIM5 Abl2 mouse Y439 447923 RLMTGDTytAHAGAK PK_Tyr_Ser-Thr X +HCK Hck P08631 human Bcr 613 P11274 BCR human Y177 447792 ADAEKPFyVNVEFHH X 3901 +HCK Hck P08631 human ELMO1 9844 Q92556 ELMO1 human Y720 455565 IPKEPsNyDFVyDCN X X +HCK Hck P08631 human Abl 25 P00519 ABL1 human Y139 456712 VSRNAAEyLLsSGIN SH2 X +HCK Hck P08631 human Hck 3055 P08631 HCK human Y411 448168 RVIEDNEytAREGAk PK_Tyr_Ser-Thr X X 2101; 6943; 59548; 70926; 78740; 94361; 17320 +HCK Hck P08631 human STAT5B 6777 P51692 STAT5B human Y699 448198 tAkAVDGyVkPQIkQ X 9365; 9356; 9359; 9351; 4322; 9314; 3939; 40284; 5387; 14603; 66740; 51879; 72712 +HCK Hck P08631 human Abl 25 P00519 ABL1 human Y172 460505 LRyEGRVyHyRINTA SH2 X +HCK Hck P08631 human 5-LO 240 P09917 ALOX5 human Y54 33670310 ERGAVDSyDVTVDEE PLAT X +HCK Hck P08631 human Abl 25 P00519 ABL1 human Y185 450304 TAsDGKLyVsSESRF SH2 X 3009 +HCK Hck P08631 human ELMO1 9844 Q92556 ELMO1 human Y395 455874 AKHHQDAyIRIVLEN ELMO_CED12 X X +HCK Hck P08631 human ELMO1 9844 Q92556 ELMO1 human Y511 455873 SkLQNLSytEILkIR X X +HCK Hck P08631 human Hck 3055 P08631 HCK human Y522 448322 YTATEsQyQQQP___ X +HCK Hck P08631 human TBK1 29110 Q9UHD2 TBK1 human Y394 126839800 LNTIGLIyEkISLPk TBK1_ULD X +HCK Hck P08631 human 5-LO 240 P09917 ALOX5 human Y43 33670312 HLLDKPFyNDFERGA PLAT X +HCK Hck P08631 human PLCG2 5336 P16885 PLCG2 human Y1217 447939 LNNQLFLyDtHQNLR X X 3871 +HCK Hck P08631 human GRB2 2885 P62993 GRB2 human Y160 452038 QVPQQPtyVQALFDF X +Enpp1 ENPP1 Q924C3 rat ENPP1 85496 Q924C3 Enpp1 rat T238 451402 RPVYPTktFPNHYSI Phosphodiest X +Mos MOS P00536 mouse MEK1 5604 Q02750 MAP2K1 human S222 448513 LIDsMANsFVGtRSY Pkinase X 2338; 9121; 3958; 9154; 16211; 86128; 16780; 75262 +Mos MOS P00536 mouse MOS 17451 P00536 Mos mouse S25 448659 SVDSRSCsIPLVAPR X +Mos MOS P00536 mouse MEK1 5604 Q02750 MAP2K1 human S218 448514 VsGQLIDsMANsFVG Pkinase X 9121; 3958; 9154; 86128 +Mos MOS P00536 mouse MyoD 17927 P10085 Myod1 mouse S237 3188104 YSEAAREsRPGKSAA Myf5 X X +Mos MOS P00536 mouse MOS 17451 P00536 Mos mouse S232 450040 DLRCRQAsPHHIGGT Pkinase X +MAP3K11 MLK3 Q16584 human GLI1 2735 P08151 GLI1 human S1089 1873647706 NMAVGNMsVLLRSLP X X +MAP3K11 MLK3 Q16584 human PIN1 5300 Q13526 PIN1 human S138 25519816 QkPFEDAsFALrTGE Rotamase X X +MAP3K11 MLK3 Q16584 human AMPKA1 5562 Q13131 PRKAA1 human T183 448786 sDGEFLRtsCGsPNy Pkinase X X 2535; 2531; 4188; 5256; 50081; 74281 +MAP3K11 MLK3 Q16584 human MLK3 4296 Q16584 MAP3K11 human T277 448263 LAREWHKtTQMsAAG PK_Tyr_Ser-Thr X +MAP3K11 MLK3 Q16584 human PAK1 5058 Q13153 PAK1 human S204 448173 tKsVyTRsVIEPLPV X X 2605 +MAP3K11 MLK3 Q16584 human PAK1 5058 Q13153 PAK1 human S133 5832238 DVLEFyNsKKtsNsQ X X +MAP3K11 MLK3 Q16584 human MKK4 6416 P45985 MAP2K4 human S257 447654 ISGQLVDsIAKtRDA Pkinase X X 9156; 4514; 59056; 75450 +MAP3K11 MLK3 Q16584 human KIF2A iso1 16563 P28740-1 Kif2a mouse T245 50269505 TRYLENQtFRFDYAF Kinesin X +MAP3K11 MLK3 Q16584 human MLK3 4296 Q16584 MAP3K11 human S281 448262 WHKtTQMsAAGTYAW PK_Tyr_Ser-Thr X +MAP3K11 MLK3 Q16584 human MKK3 5606 P46734 MAP2K3 human S218 448276 IsGyLVDsVAKtMDA Pkinase X 9231; 9236; 12280 +MAP3K11 MLK3 Q16584 human GLI1 2735 P08151 GLI1 human T394 1873647704 HGPDAHVtKRHRGDG X X +MAP3K11 MLK3 Q16584 human MKK4 26398 P47809 Map2k4 mouse T259 447656 LVDsIAKtRDAGCRP Pkinase X 9151; 9156 +MAP3K11 MLK3 Q16584 human MKK4 26398 P47809 Map2k4 mouse S255 447654 ISGQLVDsIAKtRDA Pkinase X 9156; 4514; 59056; 75450 +MAP3K11 MLK3 Q16584 human MKK3 5606 P46734 MAP2K3 human T222 448277 LVDsVAKtMDAGCKP Pkinase X +MAP3K11 MLK3 Q16584 human MKK4 6416 P45985 MAP2K4 human T261 447656 LVDsIAKtRDAGCRP Pkinase X X 9151; 9156 +Tgfbr2 TGFBR2 iso1 Q62312-1 mouse TGFBR1 21812 Q64729 Tgfbr1 mouse S165 448244 VPNEEDPsLDRPFIS X +PDK3 PDHK3 Q15120 human PDHA1 5160 P08559 PDHA1 human S300 448259 sMsDPGVsyRtREEI E1_dh X +PDK3 PDHK3 Q15120 human PDHA1 18597 P35486 Pdha1 mouse S293 448258 TYRyHGHsMsDPGVs E1_dh X 31866; 37115; 48447 +PDK3 PDHK3 Q15120 human PDHA1 5160 P08559 PDHA1 human S293 448258 TYRyHGHsMsDPGVs E1_dh X 31866; 37115; 48447 +PDK3 PDHK3 Q15120 human PDHA2 5161 P29803 PDHA2 human S298 458870 sMsDPGVsyRtREEI E1_dh X +PDK3 PDHK3 Q15120 human PDHA2 5161 P29803 PDHA2 human S291 458869 TYRyHGHsMsDPGVs E1_dh X 31866; 37115; 48447 +Camk2d CAMK2D Q6PHZ2 mouse HDAC5 15184 Q9Z2V6 Hdac5 mouse S488 447996 RPLSRtQsSPLPQSP X 3424 +Camk2d CAMK2D Q6PHZ2 mouse GLO1 109801 Q9CPU0 Glo1 mouse T107 7106304 ELTHNWGtEDDETQS Glyoxalase X +Camk2d CAMK2D Q6PHZ2 mouse PLB 18821 P61014 Pln mouse T17 448115 SAIRRAstIEMPQQA Phospholamban X 8496 +Camk2d CAMK2D Q6PHZ2 mouse MYBPC3 17868 O70468 Mybpc3 mouse S302 471081 sLLKKRDsFRRDskL X X +Camk2d CAMK2D Q6PHZ2 mouse RYR2 20191 E9Q401 Ryr2 mouse S2813 458801 IsQtsQVsIDAAHGY X +Camk2d CAMK2D Q6PHZ2 mouse STX3 20908 Q64704 Stx3 mouse T14 31960301 QLKAKQLtQDDDTDE X +Camk2d CAMK2D Q6PHZ2 mouse GLO1 2739 Q04760 GLO1 human T107 7106304 ELTHNWGtEDDETQS Glyoxalase X +Dyrk3 DYRK3 Q922Y0 mouse DYRK3 226419 Q922Y0 Dyrk3 mouse Y368 451268 EYQKLYtyIQSRFYR Pkinase X +Dyrk3 DYRK3 Q922Y0 mouse CREB 1385 P16220 CREB1 human S119 448228 EILsRRPsyRkILND pKID X 9187; 9196; 9198; 4095; 14228; 14001; 39561; 80120; 44864; 54960; 95995 +ROCK2 ROCK2 O75116 human NHE1 6548 P19634 SLC9A1 human T653 4729330 LRsYNRHtLVADPyE NEXCaM_BD X +ROCK2 ROCK2 O75116 human CRMP-2 395155 Q90635 DPYSL2 chicken T555 448084 DNIPRRTtQRIVAPP X +ROCK2 ROCK2 O75116 human BACE 23621 P56817 BACE1 human S498 450178 DDFADDIsLLk____ X +ROCK2 ROCK2 O75116 human MFN2 64476 Q8R500 Mfn2 rat S442 4746700 AEEIRRLsVLVDEYQ X +ROCK2 ROCK2 O75116 human MRLC2V 4633 P10916 MYL2 human S15 2846506 KRAGGANsNVFsMFE X X +ROCK2 ROCK2 O75116 human SNAP-25 20614 P60879 Snap25 mouse T138 449875 GGFIRRVtNDARENE SNAP-25 X +ROCK2 ROCK2 O75116 human PPP1R14A 94274 Q96A00 PPP1R14A human T38 449098 QkRHARVtVkYDRRE PP1_inhibitor X +ROCK2 ROCK2 O75116 human p47phox 653361 P14598 NCF1 human S320 451726 QRsRKRLsQDAYRRN NECFESHC X X +ROCK2 ROCK2 O75116 human ROCK2 9475 O75116 ROCK2 human S1374 468651 MkIQQNQsIRRPsRQ X +ROCK2 ROCK2 O75116 human endophilin A1 6456 Q99962 SH3GL2 human T14 457634 KKQFHKAtQKVSEKV BAR X X +ROCK2 ROCK2 O75116 human NFAT2 18018 O88942 Nfatc1 mouse S243 4700879 PRHsPSTsPRAsITE X +ROCK2 ROCK2 O75116 human calponin 3 71994 Q9DAW9 Cnn3 mouse S293 4776192 QGtGTNGsEIsDsDy X +ROCK2 ROCK2 O75116 human TNNI3 21954 P48787 Tnni3 mouse T144 451483 RGKFKRPtLRRVRIs Troponin X +ROCK2 ROCK2 O75116 human ROCK2 9475 O75116 ROCK2 human S1366 23003812 ARssPRtsMkIQQNQ X +ROCK2 ROCK2 O75116 human MYPT1 116670 Q10728 Ppp1r12a rat S854 451999 RPREKRRstGVSFWT X +ROCK2 ROCK2 O75116 human LIMK2 3985 P53671 LIMK2 human T505 448683 NDRKKRYtVVGNPYW PK_Tyr_Ser-Thr X 3841 +ROCK2 ROCK2 O75116 human Vimentin 7431 P08670 VIM human S72 449026 ssAVrLrssVPGVRL Filament_head X +ROCK2 ROCK2 O75116 human CRMP-2 25416 P47942 Dpysl2 rat T555 448084 DNIPRRTtQRIVAPP X +ROCK2 ROCK2 O75116 human EEF1A1 1915 P68104 EEF1A1 human T432 2862100 AVRDMrQtVAVGVIk GTP_EFTU_D3 X +ROCK2 ROCK2 O75116 human TNNI3 21954 P48787 Tnni3 mouse S24 448424 APVRRRssANyRAYA Troponin-I_N X +ROCK2 ROCK2 O75116 human p47phox 653361 P14598 NCF1 human S304 449406 GAPPRRssIRNAHsI NECFESHC X X +ROCK2 ROCK2 O75116 human IRF4 16364 Q64287 Irf4 mouse S447 12265165 HRSLRHssIQE____ X +ROCK2 ROCK2 O75116 human MYPT1 4659 O14974 PPP1R12A human T696 448587 ARQsRRstQGVtLtD X 5163 +ROCK2 ROCK2 O75116 human calponin 3 71994 Q9DAW9 Cnn3 mouse S296 4776198 GTNGsEIsDsDyQAE X +ROCK2 ROCK2 O75116 human ROCK2 9475 O75116 ROCK2 human S1379 3892345 NQsIRRPsRQLAPNK X +ROCK2 ROCK2 O75116 human IRF4 16364 Q64287 Irf4 mouse S446 26335000 YHRSLRHssIQE___ X +ROCK2 ROCK2 O75116 human p47phox 653361 P14598 NCF1 human S345 451727 QARPGPQsPGsPLEE X X +ROCK2 ROCK2 O75116 human MYPT1 396020 Q90623 PPP1R12A chicken T695 448587 ARQSRRstQGVTLTD X 5163 +ROCK2 ROCK2 O75116 human SORL1 6653 Q92673 SORL1 human S2206 11546400 APMITGFsDDVPMVI X +ROCK2 ROCK2 O75116 human CRMP-2 1808 Q16555 DPYSL2 human T555 448084 DNIPRRttQRIVAPP X +ROCK2 ROCK2 O75116 human NFAT2 4772 O95644 NFATC1 human S241 4700879 PRHsPSTsPRAsVTE X +ROCK2 ROCK2 O75116 human DAB2 1601 P98082 DAB2 human S723 18008467 KPAPRQVsLPVTkst X +ROCK2 ROCK2 O75116 human APP iso4 351 P05067-4 APP human T654 448201 MLKKKQYtsIHHGVV APP_amyloid X +ROCK2 ROCK2 O75116 human p47phox 653361 P14598 NCF1 human S315 451725 AHsIHQRsRKRLsQD NECFESHC X X +ROCK2 ROCK2 O75116 human TNNI3 21954 P48787 Tnni3 mouse S23 448423 PAPVRRRssANyRAY Troponin-I_N X +ROCK2 ROCK2 O75116 human p47phox 653361 P14598 NCF1 human S328 449404 QDAYRRNsVRFLQQR NECFESHC X X +ROCK2 ROCK2 O75116 human calponin 3 1266 Q15417 CNN3 human S293 4776192 QGtGTNGsEIsDSDy X +ROCK2 ROCK2 O75116 human KIF2A iso1 16563 P28740-1 Kif2a mouse T482 50269511 PFRAsKLtQVLRDsF Kinesin X +ROCK2 ROCK2 O75116 human PPP1R14B 26472 Q96C90 PPP1R14B human T57 1904503 VRRQGKVtVkYDRKE PP1_inhibitor X +ROCK2 ROCK2 O75116 human MYPT1 17931 Q9DBR7 Ppp1r12a mouse T852 452075 PREKRRstGVSFWtQ X 4563 +Csf1r CSFR P09581 mouse CSFR 12978 P09581 Csf1r mouse Y721 448364 ssQGVDTyVEMRPVS PK_Tyr_Ser-Thr X X 3151; 3155; 64191 +Csf1r CSFR P09581 mouse CSFR 12978 P09581 Csf1r mouse Y697 451527 DsEGDssykNIHLEK PK_Tyr_Ser-Thr X X 3399 +Csf1r CSFR P09581 mouse CSFR 12978 P09581 Csf1r mouse Y974 455527 PLLQPNNyQFC____ X +Csf1r CSFR P09581 mouse CSFR 12978 P09581 Csf1r mouse Y807 448365 DIMNDSNyVVkGNAR PK_Tyr_Ser-Thr X X 3154 +Csf1r CSFR P09581 mouse CSFR 12978 P09581 Csf1r mouse Y921 455145 LERRDQDyANLPSSG X 3406 +Csf1r CSFR P09581 mouse CSFR 12978 P09581 Csf1r mouse Y706 451528 NIHLEKKyVRRDsGF PK_Tyr_Ser-Thr X 3080; 14591 +Pak3 PAK3 Q62829 rat PAK3 29433 Q62829 Pak3 rat S50 448125 NKKARLRsIFPGGGD X +Pak3 PAK3 Q62829 rat PAK3 29433 Q62829 Pak3 rat T421 448126 PEQSKRstMVGTPYW Pkinase X 2601 +Pak3 PAK3 Q62829 rat GluR1 50592 P19490 Gria1 rat S863 448566 TSTLPRNsGAGASGG X 8084 +Pak3 PAK3 Q62829 rat SYN1 281510 P17599 SYN1 cow S551 451574 PATRPPAsPsPQRQA X +Pak3 PAK3 Q62829 rat MYO6 17920 Q64331 Myo6 mouse T405 449089 TAGGTKGtVIkVPLk Myosin_head X +Pak3 PAK3 Q62829 rat MEK1 170851 Q01986 Map2k1 rat S298 448284 RtPGRPLsSYGMDSR Pkinase X 9128; 98195 +Pak3 PAK3 Q62829 rat SYN1 281510 P17599 SYN1 cow S605 450236 AGPTRQAsQAGPMPR X +Pak3 PAK3 Q62829 rat PAK3 29433 Q62829 Pak3 rat S139 448123 VNNQKYMsFTSGDKS X 2606 +Pak3 PAK3 Q62829 rat SYN1 281510 P17599 SYN1 cow S9 448378 NYLRRRLsDSNFMAN Synapsin_N X +Pak3 PAK3 Q62829 rat RAF1 5894 P04049 RAF1 human S338 447742 RPRGQRDssyyWEIE X X 9427 +Cdk16 CDK16 Q04735 mouse NSF 18195 P46460 Nsf mouse S569 460358 FPFIKICsPDKMIGF AAA X +Pak4 PAK4 B5DF62 rat TORC1 684527 Q157S1 Crtc1 rat S215 60885604 KAGSRPKsCEVPGIN TORC_M X +MAP3K14 Nik Q99558 human CREB 12912 Q01147 Creb1 mouse S128 448547 RkILNDLssDAPGVP pKID X +MAP3K14 Nik Q99558 human IKKA 1147 O15111 CHUK human S176 447778 AKDVDQGsLCtsFVG Pkinase X X 2078; 2697; 14938; 92255; 36516; 36214 +MAP3K14 Nik Q99558 human G6PD 2539 P11413 G6PD human S486 1871700807 PIPYIYGsRGPtEAD G6PD_C X +MAP3K14 Nik Q99558 human G6PD 2539 P11413 G6PD human S278 1871700805 VAMEKPAsTNSDDVR G6PD_C X +MAP3K14 Nik Q99558 human CREB 12912 Q01147 Creb1 mouse S100 451809 EsEDsQEsVDsVTDs pKID X +MAP3K14 Nik Q99558 human NFkB-p100 4791 Q00653 NFKB2 human S870 450167 kEDsAyGsQsVEQEA X 4810 +MAP3K14 Nik Q99558 human IkB-alpha 4792 P25963 NFKBIA human S32 448203 LLDDRHDsGLDsMkD X 5210; 2859; 9246; 5209 +MAP3K14 Nik Q99558 human ARP2 10097 P61160 ACTR2 human T238 36440501 QKLALEttVLVESYT Actin X X +MAP3K14 Nik Q99558 human Moesin 81521 O35763 Msn rat T558 447706 LGRDKYKtLRQIRQG ERM_C X 3141; 3726; 32600 +MAP3K14 Nik Q99558 human IkB-alpha 4792 P25963 NFKBIA human S36 448204 RHDsGLDsMkDEEyE X 5210; 9246 +MAP3K14 Nik Q99558 human ARP2 10097 P61160 ACTR2 human Y202 38546300 kLLLLRGyAFNHsAD Actin X X +MAP3K14 Nik Q99558 human G6PD 2539 P11413 G6PD human S40 1871700806 IFIIMGAsGDLAKKK G6PD_N X X +MAP3K14 Nik Q99558 human ARP2 10097 P61160 ACTR2 human T237 36440502 EQKLALEttVLVESY Actin X X +MAP3K14 Nik Q99558 human IKKB 3551 O14920 IKBKB human S177 447492 AkELDQGsLCtsFVG Pkinase X 2078; 2697; 2694; 14938; 92255; 36516; 36214 +MAP3K14 Nik Q99558 human IKKB 3551 O14920 IKBKB human S181 447489 DQGsLCtsFVGTLQy Pkinase X 2697; 2694; 14938; 92255; 36516; 36214 +MAP3K14 Nik Q99558 human JAK2 16452 Q62120 Jak2 mouse S633 1880516404 QEFVKFGsLDTyLKK X +MAP3K14 Nik Q99558 human Ezrin 54319 P31977 Ezr rat T567 448104 QGRDKYKtLRQIRQG ERM_C X X 3141; 3726; 32600 +MAP3K14 Nik Q99558 human IKKA 1147 O15111 CHUK human S180 447779 DQGsLCtsFVGTLQY Pkinase X 2697; 14938; 92255; 36516; 36214 +MAP3K14 Nik Q99558 human G6PD 2539 P11413 G6PD human S8 31088663 MAEQVALsrtQVCGI X +MAP3K14 Nik Q99558 human NFkB-p100 4791 Q00653 NFKB2 human S866 450166 tAEVkEDsAyGsQsV X 4810 +RPS6KB1 p70S6K P23443 human BACH2 60468 Q9BYV9 BACH2 human S521 470117 ETRTRTssSCSsYsY X +RPS6KB1 p70S6K P23443 human IRS1 3667 P35568 IRS1 human S636 447506 sGDyMPMsPKsVSAP X X 2388 +RPS6KB1 p70S6K P23443 human NDRG2 57447 Q9UN36 NDRG2 human S350 454251 RsRsRtLsQssEsGt X +RPS6KB1 p70S6K P23443 human KHSRP 8570 Q92945 KHSRP human S395 1876620110 DLLQSLrsGPPGPPG X +RPS6KB1 p70S6K P23443 human PDCD4 27250 Q53EL6 PDCD4 human S67 458381 kRRLRKNssRDsGrG X +RPS6KB1 p70S6K P23443 human p63 8626 Q9H3D4 TP63 human S560 4668108 LARLGCSsCLDYFTT SAM_2 X X +RPS6KB1 p70S6K P23443 human mTOR 2475 P42345 MTOR human S2448 447578 RsRtRtDsysAGQsV X X 2971; 2976; 5536; 54932 +RPS6KB1 p70S6K P23443 human TRB2 28951 Q92519 TRIB2 human S83 29604200 FRAVHLHsGEELVCK Pkinase X +RPS6KB1 p70S6K P23443 human S6 6194 P62753 RPS6 human S240 448094 RLssLRAstsKsEss X X 2215; 5364; 5018; 93315; 5044; 13020; 14236; 9468; 35708; 88441; 34918 +RPS6KB1 p70S6K P23443 human p70S6K 6198 P23443 RPS6KB1 human T412 448607 NQVFLGFtyVAPsVL Pkinase_C X 9206; 9234; 9205; 9209; 97596 +RPS6KB1 p70S6K P23443 human SMN 6606 Q16637 SMN1 human S49 1873529903 AyDkAVAsFkHALkN SMN X X +RPS6KB1 p70S6K P23443 human EEF2K 29904 O00418 EEF2K human S366 447827 sPQVRtLsGSRPPLL X X 3691 +RPS6KB1 p70S6K P23443 human BACH2 60468 Q9BYV9 BACH2 human S520 53354442 LETRTRTssSCSsYs X +RPS6KB1 p70S6K P23443 human Mad1 4084 Q05195 MXD1 human S145 2807903 IERIRMDsIGSTVSS X X +RPS6KB1 p70S6K P23443 human IRS1 3667 P35568 IRS1 human S307 450190 TRRsRtEsItAtsPA X X 2384; 2491 +RPS6KB1 p70S6K P23443 human RMP 8725 O94763 URI1 human S372 1028301 AKRKRKNstGsGHsA X X +RPS6KB1 p70S6K P23443 human Tau iso8 4137 P10636-8 MAPT human S262 447930 NVKskIGstENLkHQ Tubulin-binding X +RPS6KB1 p70S6K P23443 human PDCD4 27250 Q53EL6 PDCD4 human S457 458382 RGRKRFVsEGDGGRL X +RPS6KB1 p70S6K P23443 human IRS1 3667 P35568 IRS1 human S527 447561 RFRKRtHsAGtsPtI X +RPS6KB1 p70S6K P23443 human NCBP1 4686 Q09161 NCBP1 human S7 9764056 _MSRRRHsDENDGGQ X +RPS6KB1 p70S6K P23443 human PGC-1 alpha 19017 O70343 Ppargc1a mouse S568 20612406 PQRMRSRsRsFsRHR X X +RPS6KB1 p70S6K P23443 human IRS1 3667 P35568 IRS1 human S270 447566 EFRPRsKsQSssNCs X X +RPS6KB1 p70S6K P23443 human MDM2 17246 P23804 Mdm2 mouse S163 448130 SSRRRsIsEtEENTD X 3521 +RPS6KB1 p70S6K P23443 human GSK3B 56637 Q9WV60 Gsk3b mouse S9 449111 SGRPRttsFAEsCKP X 9336; 9331; 9327; 9323; 9322; 9325; 5558; 8566; 79774; 8466; 25462; 14026; 14332; 14310; 14630 +RPS6KB1 p70S6K P23443 human EIF4B 75705 Q8BGD9 Eif4b mouse S422 451290 RERsRtGsEssQtGA X 3591 +RPS6KB1 p70S6K P23443 human H2B 3018 P33778 H2BC3 human S36 449903 RKRsRkEsysIyVyk Histone X X +RPS6KB1 p70S6K P23443 human PIP5K1C 23396 O60331 PIP5K1C human T553 487222 QPRYRRRtQssGQDG X X +RPS6KB1 p70S6K P23443 human BAD 64639 O35147 Bad rat S137 447862 PFRGRsRsAPPNLWA Bcl-2_BAD X 9295; 5286; 4366 +RPS6KB1 p70S6K P23443 human SKAR 84271 Q9BY77 POLDIP3 human S385 454011 PRRVNsAsSsNPPAE X X +RPS6KB1 p70S6K P23443 human TRBP 6895 Q15633 TARBP2 human S283 27457469 ILSLRsCsLGsLGAL X +RPS6KB1 p70S6K P23443 human mTOR 2475 P42345 MTOR human T2446 450853 NKRsRtRtDsysAGQ X X +RPS6KB1 p70S6K P23443 human FMR1 2332 Q06787 FMR1 human S500 469583 NSEASNAsETESDHR FXMRP1_C_core X +RPS6KB1 p70S6K P23443 human IRS1 3667 P35568 IRS1 human S1101 453434 GCRRRHssEtFsStP X X +RPS6KB1 p70S6K P23443 human S6 6194 P62753 RPS6 human S244 448095 LRAstsKsEssQK__ X X 2215; 5364; 5018; 93315; 5044; 13020; 14236; 9468; 35708; 88441; 34918 +RPS6KB1 p70S6K P23443 human GSK3B 2932 P49841 GSK3B human S9 449111 SGRPRttsFAEsCkP X 9336; 9331; 9327; 9323; 9322; 9325; 5558; 8566; 79774; 8466; 25462; 14026; 14332; 14310; 14630 +RPS6KB1 p70S6K P23443 human Kaiso 10009 Q86T24 ZBTB33 human T606 34353150 yLSDRSStIPAMkDD X +RPS6KB1 p70S6K P23443 human NDRG2 57447 Q9UN36 NDRG2 human S332 451010 LsRsRtAsLtsAAsV X +RPS6KB1 p70S6K P23443 human BMAL1 11865 Q9WTL8 Bmal1 mouse S42 25230400 CNRKRKGsATDYQLD X 13936 +RPS6KB1 p70S6K P23443 human IRS1 16367 P35569 Irs1 mouse S1097 453434 GCRRRHssEtFSAPt X 2385 +RPS6KB1 p70S6K P23443 human Tau iso8 4137 P10636-8 MAPT human S214 447929 GsRsRtPsLPtPPtR X 77348 +RPS6KB1 p70S6K P23443 human DEPTOR 64798 Q8TB45 DEPTOR human S287 4723848 sMssCGssGyFsssP X X +RPS6KB1 p70S6K P23443 human ER-alpha 2099 P03372 ESR1 human S167 448102 GGRERLAsTNDkGSM Oest_recep X X 64508; 42101 +RPS6KB1 p70S6K P23443 human LTC4S 4056 Q16873 LTC4S human S36 40511991 ARRAFRVsPPLtTGP MAPEG X +RPS6KB1 p70S6K P23443 human S6 6194 P62753 RPS6 human S236 448093 AKRRRLssLRAstsK X X 5006; 4856; 4857; 4858; 4851; 4803; 2211; 3945; 3985; 5316; 4854; 8520; 48319; 40643; 9865; 38573; 14733; 27036; 34411; 62016; 62788; 81736; 97935; 99457; 15448 +RPS6KB1 p70S6K P23443 human MRE11A 4361 P49959 MRE11 human T597 4333497 sQrGrADtGLETSTr X X +RPS6KB1 p70S6K P23443 human CAD 790 P27708 CAD human S1859 451247 PPRIhRAsDPGLPAE X X 12662; 67235; 70307 +RPS6KB1 p70S6K P23443 human GluR1 14799 P23818 Gria1 mouse T858 3362100 NEAIRtstLPRNsGA X +RPS6KB1 p70S6K P23443 human NCBP1 4686 Q09161 NCBP1 human S22 1219020 PHKRRKtsDANEtED X +RPS6KB1 p70S6K P23443 human DEPTOR 64798 Q8TB45 DEPTOR human S286 21697912 ssMssCGssGyFsss X X +RPS6KB1 p70S6K P23443 human EGLN1 54583 Q9GZT9 EGLN1 human S125 7322687 ADPAAAAsPCRAAAG X +RPS6KB1 p70S6K P23443 human CCT2 10576 P78371 CCT2 human S260 472352 GsRVRVDstAkVAEI Cpn60_TCP1 X X +RPS6KB1 p70S6K P23443 human Tau iso8 4137 P10636-8 MAPT human T212 447934 tPGsRsRtPsLPtPP X +RPS6KB1 p70S6K P23443 human PGC-1 alpha 19017 O70343 Ppargc1a mouse S572 6421246 RSRsRsFsRHRSCSR X X +RPS6KB1 p70S6K P23443 human FMR1 14265 P35922 Fmr1 mouse S499 469583 NSEAsNAsETESDHR FXMRP1_C_core X +RPS6KB1 p70S6K P23443 human PIP5K1C 23396 O60331 PIP5K1C human S555 1855423 RYRRRtQssGQDGRP X X +RPS6KB1 p70S6K P23443 human GLI1 2735 P08151 GLI1 human S84 25123902 LTKKRALsISPLSDA X X +RPS6KB1 p70S6K P23443 human MSH6 2956 P52701 MSH6 human S309 4274110 RMVtGNGsLKRKSSR X X +RPS6KB1 p70S6K P23443 human RICTOR 253260 Q6R327 RICTOR human T1135 458276 NRRIRtLtEPsVDFN RICTOR_phospho X X 3806 +RPS6KB1 p70S6K P23443 human SRPK2 6733 P78362 SRPK2 human S494 483631 HDRSRtVsAsstGDL X +RPS6KB1 p70S6K P23443 human NCBP1 4686 Q09161 NCBP1 human T21 480103 QPHKRRKtsDANEtE X +RPS6KB1 p70S6K P23443 human EIF4B 1975 P23588 EIF4B human S422 451290 RERsRtGsEssQtGt X 3591 +RPS6KB1 p70S6K P23443 human S6 6194 P62753 RPS6 human S235 448092 IAKRRRLssLRAsts X X 5006; 4856; 4857; 4858; 4851; 4803; 2211; 3945; 3985; 5316; 4854; 8520; 48319; 40643; 9865; 38573; 14733; 27036; 34411; 62016; 62788; 81736; 97935; 99457; 15448 +RPS6KB1 p70S6K P23443 human SKAR 84271 Q9BY77 POLDIP3 human S383 454010 ELPRRVNsAsSsNPP X X +RPS6KB1 p70S6K P23443 human DEPTOR 64798 Q8TB45 DEPTOR human S291 4723858 CGssGyFsssPtLss X X +RPS6KB1 p70S6K P23443 human DNAJC2 22791 P54103 Dnajc2 mouse S47 469782 KRRNRNAstsFQELE X 12397 +RPS6KB1 p70S6K P23443 human EPRS 2058 P07814 EPRS1 human S999 9720900 NQGGGLsssGAGEGQ X X +RPS6KB1 p70S6K P23443 human CDK1 983 P06493 CDK1 human S39 455465 MkkIRLEsEEEGVPs Pkinase X X +Ulk2 ULK2 Q9QY01 mouse beclin 1 56208 O88597 Becn1 mouse S14 25268704 SSSTMQVsFVCQRCS X 84966 +TRPM7 ChaK1 Q96QT4 human MYH9 4627 P35579 MYH9 human S1808 2482304 VKskykAsItALEAk Myosin_tail_1 X +TRPM7 ChaK1 Q96QT4 human ChaK1 54822 Q96QT4 TRPM7 human T1482 2512905 VssLAGFtDCHRTsI X +TRPM7 ChaK1 Q96QT4 human ChaK1 54822 Q96QT4 TRPM7 human S1258 2512936 AQkAsEAsKVHNEIt X +TRPM7 ChaK1 Q96QT4 human ChaK1 54822 Q96QT4 TRPM7 human S1287 2512918 DDGPVRPsVWKKHGV X +TRPM7 ChaK1 Q96QT4 human ChaK1 54822 Q96QT4 TRPM7 human T1537 2512912 EMPsEEGtLNGLtsP X +TRPM7 ChaK1 Q96QT4 human ChaK1 58800 Q923J1 Trpm7 mouse S1567 455464 NLMRLsQsIPFVPVP X +TRPM7 ChaK1 Q96QT4 human ChaK1 54822 Q96QT4 TRPM7 human S1404 2512922 PPTKFFVstPsQPsC X +TRPM7 ChaK1 Q96QT4 human ChaK1 54822 Q96QT4 TRPM7 human S1387 2512908 KNQKLGssSTsIPHL X +TRPM7 ChaK1 Q96QT4 human ChaK1 54822 Q96QT4 TRPM7 human T1405 2512940 PTKFFVstPsQPsCK X +TRPM7 ChaK1 Q96QT4 human PLCG2 5336 P16885 PLCG2 human T1045 25692905 LQPESMRtEkyDPMP X +TRPM7 ChaK1 Q96QT4 human ANXA1 301 P04083 ANXA1 human S5 452051 ___MAMVsEFLKQAW X +TRPM7 ChaK1 Q96QT4 human RHOA 11848 Q9QUI0 Rhoa mouse S188 449035 ARRGKKKsGCLIL__ X X +TRPM7 ChaK1 Q96QT4 human PLCG2 5336 P16885 PLCG2 human S1164 25692906 AVKSGFRsVPLKNGY C2 X X +TRPM7 ChaK1 Q96QT4 human MYH9 17886 Q8VDD5 Myh9 mouse S1799 2482305 AkLQEMEsAVksKyK Myosin_tail_1 X +TRPM7 ChaK1 Q96QT4 human ChaK1 54822 Q96QT4 TRPM7 human S1390 2512931 KLGssSTsIPHLssP X +TRPM7 ChaK1 Q96QT4 human ChaK1 54822 Q96QT4 TRPM7 human T1435 2512928 KATEGDNtEFGAFVG X +TRPM7 ChaK1 Q96QT4 human ChaK1 54822 Q96QT4 TRPM7 human T1265 2512902 sKVHNEItRELsIsK X +TRPM7 ChaK1 Q96QT4 human ChaK1 54822 Q96QT4 TRPM7 human T1542 2512927 EGtLNGLtsPFKPAM X +TRPM7 ChaK1 Q96QT4 human ChaK1 54822 Q96QT4 TRPM7 human S1463 2512920 sNKIKILsNNNTsEN X +TRPM7 ChaK1 Q96QT4 human EEF2K 29904 O00418 EEF2K human S78 450687 ssGsPANsFHFkEAW X +TRPM7 ChaK1 Q96QT4 human ChaK1 54822 Q96QT4 TRPM7 human T1685 2512925 QRAAQKLtFAFNQMK Alpha_kinase X +TRPM7 ChaK1 Q96QT4 human TMOD1 7111 P28289 TMOD1 human S2 22561901 ______MsyRRELEK X +TRPM7 ChaK1 Q96QT4 human ChaK1 54822 Q96QT4 TRPM7 human S1851 2512937 LNLQPGNsTKESEST X +TRPM7 ChaK1 Q96QT4 human ChaK1 54822 Q96QT4 TRPM7 human S1358 2512933 SSGALFPsAVsPPEL X +TRPM7 ChaK1 Q96QT4 human TMOD1 7111 P28289 TMOD1 human T54 22561900 GLRQKDQtTKAPTGP Tropomodulin X +TRPM7 ChaK1 Q96QT4 human ChaK1 54822 Q96QT4 TRPM7 human S1695 2512916 FNQMKPKsIPYSPRF Alpha_kinase X +TRPM7 ChaK1 Q96QT4 human ChaK1 54822 Q96QT4 TRPM7 human S1468 2512929 ILsNNNTsENtLkRV X +TRPM7 ChaK1 Q96QT4 human ChaK1 58800 Q923J1 Trpm7 mouse S1511 455463 EDsPEVdsKAALLPD X +TRPM7 ChaK1 Q96QT4 human ChaK1 54822 Q96QT4 TRPM7 human S1543 2512904 GtLNGLtsPFKPAMD X +TRPM7 ChaK1 Q96QT4 human ChaK1 54822 Q96QT4 TRPM7 human S1660 2512923 EVVNTWSsIYKEDTV Alpha_kinase X +TRPM7 ChaK1 Q96QT4 human ChaK1 54822 Q96QT4 TRPM7 human S1193 2512911 DDKFHsGsEERIRVT X +TRPM7 ChaK1 Q96QT4 human ChaK1 54822 Q96QT4 TRPM7 human S1477 2512935 NtLkRVssLAGFtDC X +TRPM7 ChaK1 Q96QT4 human ChaK1 54822 Q96QT4 TRPM7 human S1860 2512924 KESESTNsVRLML__ X +TRPM7 ChaK1 Q96QT4 human ChaK1 54822 Q96QT4 TRPM7 human T1471 2512919 NNNTsENtLkRVssL X +TRPM7 ChaK1 Q96QT4 human ChaK1 54822 Q96QT4 TRPM7 human S1569 455464 NLMRLsQsIPFTPVP X +TRPM7 ChaK1 Q96QT4 human ANXA1 327662 P46193 ANXA1 cow S5 452051 ___MAMVsEFLKQAW X +TRPM7 ChaK1 Q96QT4 human ChaK1 54822 Q96QT4 TRPM7 human T1583 2512921 PPRGEPVtVYRLEES X +TRPM7 ChaK1 Q96QT4 human ChaK1 54822 Q96QT4 TRPM7 human T1830 2512906 DLKRNDYtPDkIIFP X +TRPM7 ChaK1 Q96QT4 human ChaK1 58800 Q923J1 Trpm7 mouse S1360 31909861 ALFPSAVsPPELRQR X +TRPM7 ChaK1 Q96QT4 human MYH9 17886 Q8VDD5 Myh9 mouse T1931 2482306 GDLPFVVtRRIVRKG X +TRPM7 ChaK1 Q96QT4 human ChaK1 54822 Q96QT4 TRPM7 human S1615 2512930 CAKIEFLsKEEMGGG X +TRPM7 ChaK1 Q96QT4 human ChaK1 54822 Q96QT4 TRPM7 human S1446 2512907 AFVGHRDsMDLQRFK X +TRPM7 ChaK1 Q96QT4 human MYH9 4627 P35579 MYH9 human S1803 2482303 EMEGtVKskykAsIt Myosin_tail_1 X +TRPM7 ChaK1 Q96QT4 human ChaK1 54822 Q96QT4 TRPM7 human S1456 2512910 LQRFKEtsNKIKILs X +TRPM7 ChaK1 Q96QT4 human ChaK1 54822 Q96QT4 TRPM7 human S1255 2512900 TLTAQkAsEAsKVHN X +TRPM7 ChaK1 Q96QT4 human ChaK1 54822 Q96QT4 TRPM7 human T1455 2512932 DLQRFKEtsNKIKIL X +TRPM7 ChaK1 Q96QT4 human ChaK1 58800 Q923J1 Trpm7 mouse S1403 2512922 PPtKFsVstPsQPSC X +TRPM7 ChaK1 Q96QT4 human ChaK1 54822 Q96QT4 TRPM7 human S1779 2512909 GENLTDPsVIKAEEK Alpha_kinase X +TRPM7 ChaK1 Q96QT4 human ChaK1 54822 Q96QT4 TRPM7 human T1163 2512913 DGPkLFLtEEDQkKL X +TRPM7 ChaK1 Q96QT4 human ChaK1 54822 Q96QT4 TRPM7 human S1476 2512941 ENtLkRVssLAGFtD X +TRPM7 ChaK1 Q96QT4 human ChaK1 54822 Q96QT4 TRPM7 human S1598 2512915 SPNILNNsMSSWSQL X +TRPM7 ChaK1 Q96QT4 human ChaK1 54822 Q96QT4 TRPM7 human S1567 2512914 RNNLMRLsQsIPFTP X +TRPM7 ChaK1 Q96QT4 human MYH9 17886 Q8VDD5 Myh9 mouse S1803 2482303 EMEsAVksKyKASIA Myosin_tail_1 X +TRPM7 ChaK1 Q96QT4 human ChaK1 54822 Q96QT4 TRPM7 human S1191 2512901 EKDDKFHsGsEERIR X +TRPM7 ChaK1 Q96QT4 human ChaK1 54822 Q96QT4 TRPM7 human T1551 2512934 PFKPAMDtNYYYSAV X +TRPM7 ChaK1 Q96QT4 human ChaK1 54822 Q96QT4 TRPM7 human S1493 467645 RTsIPVHsKQAEKIs X +TRPM7 ChaK1 Q96QT4 human ChaK1 54822 Q96QT4 TRPM7 human S1533 2512903 PsNREMPsEEGtLNG X +TRPM7 ChaK1 Q96QT4 human ChaK1 54822 Q96QT4 TRPM7 human T1505 480441 KIsRRPstEDtHEVD X +TRPM7 ChaK1 Q96QT4 human ChaK1 54822 Q96QT4 TRPM7 human S1271 2512926 ItRELsIsKHLAQNL X +TRPM7 ChaK1 Q96QT4 human MYH9 4627 P35579 MYH9 human T1800 2482302 kLQEMEGtVKskykA Myosin_tail_1 X +TRPM7 ChaK1 Q96QT4 human ChaK1 54822 Q96QT4 TRPM7 human T1508 2512938 RRPstEDtHEVDsKA X +TRPM7 ChaK1 Q96QT4 human ChaK1 54822 Q96QT4 TRPM7 human S1407 2512939 KFFVstPsQPsCKsH X +TRPM7 ChaK1 Q96QT4 human ChaK1 54822 Q96QT4 TRPM7 human S1513 455463 EDtHEVDsKAALIPD X +TRPM7 ChaK1 Q96QT4 human ChaK1 54822 Q96QT4 TRPM7 human S1527 2512917 DWLQDRPsNREMPsE X +Acvr1b ALK4 Q61271 mouse TTRAP 51567 O95551 TDP2 human T88 12563300 PkTyVDLtNEEtTDs X +Acvr1b ALK4 Q61271 mouse TTRAP 51567 O95551 TDP2 human T92 12563301 VDLtNEEtTDsTTSK X +MERTK Mer Q12866 human MLKL 197259 Q8NB16 MLKL human Y376 1868624704 DRVkstAyLSPQELE PK_Tyr_Ser-Thr X +MERTK Mer Q12866 human Akt1 207 P31749 AKT1 human S473 447855 RPHFPQFsysAsGtA Pkinase_C X 9271; 3787; 4060; 4051; 5102; 4058; 2336; 2337; 4075; 4070; 5012; 4071; 92982; 5315; 9563; 9018; 12694; 52240; 11962; 15116; 88106; 26580; 68035; 31957; 23430; 20235 +MERTK Mer Q12866 human STAT5A 6776 P42229 STAT5A human Y694 447767 LAkAVDGyVkPQIkQ X 9365; 9356; 9359; 9351; 4322; 9314; 3939; 40284; 5387; 14603; 66740; 51879; 72712 +MERTK Mer Q12866 human STAT3 6774 P40763 STAT3 human Y705 448192 DPGsAAPyLktKFIC X 4093; 9145; 4324; 9131; 9138; 4323; 4074; 4113; 48313; 20977; 25023; 8119; 52075; 52527; 73533; 61958; 73452; 16185; 74309 +MERTK Mer Q12866 human Mer 10461 Q12866 MERTK human Y749 449988 FGLsKKIysGDyyRQ PK_Tyr_Ser-Thr X X 44463 +MERTK Mer Q12866 human STAT5B 6777 P51692 STAT5B human Y699 448198 tAkAVDGyVkPQIkQ X 9365; 9356; 9359; 9351; 4322; 9314; 3939; 40284; 5387; 14603; 66740; 51879; 72712 +MERTK Mer Q12866 human Mer 10461 Q12866 MERTK human Y754 449990 KIysGDyyRQGRIAk PK_Tyr_Ser-Thr X X +MERTK Mer Q12866 human Mer 10461 Q12866 MERTK human Y753 449989 KKIysGDyyRQGRIA PK_Tyr_Ser-Thr X X +MERTK Mer Q12866 human Akt1 207 P31749 AKT1 human T308 447856 kDGAtMKtFCGtPEy Pkinase X 5106; 2965; 9275; 4056; 5056; 13842; 13038; 43506; 48646; 86758; 80722; 77440; 80556 +PAK6 PAK6 Q9NQU5 human PACSIN1 29993 Q9BY11 PACSIN1 human S346 4730476 SQAGDRGsVssYDRG X +PAK6 PAK6 Q9NQU5 human MDM2 4193 Q00987 MDM2 human S186 448131 RQRkRHksDsIsLsF X X +PAK6 PAK6 Q9NQU5 human ICAP1 9270 O14713 ITGB1BP1 human S10 1872961000 RKGKKRHssSsSQSS ICAP-1_inte_bdg X +PAK6 PAK6 Q9NQU5 human MDM2 4193 Q00987 MDM2 human T158 27620700 HLVSRPstSsRRRAI X X +PAK6 PAK6 Q9NQU5 human CTBP2 1488 P56545 CTBP2 human S164 2089803 REGTRVQsVEQIREV 2-Hacid_dh_C; 2-Hacid_dh X +PAK6 PAK6 Q9NQU5 human AR 367 P10275 AR human S579 4275600 YGALTCGsCKVFFKR zf-C4 X X +PAK6 PAK6 Q9NQU5 human CTBP1 1487 Q13363 CTBP1 human S100 2089801 RIIVRIGsGFDNIDI 2-Hacid_dh X +PAK6 PAK6 Q9NQU5 human LIMK1 3984 P53667 LIMK1 human T508 447808 PDRKKRYtVVGNPYW PK_Tyr_Ser-Thr X 3841 +PAK6 PAK6 Q9NQU5 human CTBP1 1487 Q13363 CTBP1 human S158 455351 REGTRVQsVEQIREV 2-Hacid_dh_C; 2-Hacid_dh X +Mark3 MARK3 Q03141 mouse MITF iso8 17342 Q08874-8 Mitf mouse S173 467214 PGLTISNsCPANLPN X +PAK1 PAK1 Q13153 human FXR1 8087 P51114 FXR1 human S420 467926 sERkDELsDWsLAGE FXMRP1_C_core X +PAK1 PAK1 Q13153 human ARPC1B 10095 O15143 ARPC1B human T21 10349703 HAWNkDRtQIAICPN X X +PAK1 PAK1 Q13153 human G-alpha(z) 2781 P19086 GNAZ human S16 451242 EKEAARRsRRIDRHL G-alpha X X +PAK1 PAK1 Q13153 human PAK1 18479 O88643 Pak1 mouse T212 448176 VIEPLPVtPtRDVAt X +PAK1 PAK1 Q13153 human ARHGEF2 9181 Q92974 ARHGEF2 human S886 451365 PVDPRRRsLPAGDAL X X +PAK1 PAK1 Q13153 human MEKK1 4214 Q13233 MAP3K1 human S67 3053616 RQLRKVRsVELDQLP X +PAK1 PAK1 Q13153 human TBCB 1155 Q99426 TBCB human S128 455785 VRsFLKRsKLGRyNE X X +PAK1 PAK1 Q13153 human CRK 1398 P46108 CRK human S41 454189 VFLVRDsstsPGDyV SH2 X +PAK1 PAK1 Q13153 human CTNNB1 1499 P35222 CTNNB1 human S675 457120 QDykKRLsVELtsSL X X 9567; 4176; 68076 +PAK1 PAK1 Q13153 human SHOT1 292139 A0MZ67 Shtn1 rat S101 4761847 NKTLKRIsMLYMAKL X +PAK1 PAK1 Q13153 human GDI2 2665 P50395 GDI2 human T248 1873090100 LSAIyGGtYMLNkPI GDI X +PAK1 PAK1 Q13153 human MICAL1 64780 Q8TDZ2 MICAL1 human S817 5434440 sPERQRLssLNLtPD X +PAK1 PAK1 Q13153 human PXN 5829 P49023 PXN human S258 465488 tQQQtRIsAssAtRE X +PAK1 PAK1 Q13153 human GDI2 2665 P50395 GDI2 human S382 5829589 PIEQkFVsIsDLLVP GDI X +PAK1 PAK1 Q13153 human TBCB 1155 Q99426 TBCB human S65 455784 GVDDKFYskLDQEDA Ubiquitin_2 X X +PAK1 PAK1 Q13153 human PXN iso2 5829 P49023-2 PXN human S272 465466 ELDELMAsLSDFKFM X X +PAK1 PAK1 Q13153 human PLK1 5347 P53350 PLK1 human S49 2715404 EVLVDPRsRRRYVRG X X +PAK1 PAK1 Q13153 human H3 8350 P68431 H3C1 human S10 455676 tkQtArkstGGkAPr Histone X X 9701; 9711; 9606; 3465; 3642; 3377; 3475; 3458; 5764; 47398; 8481; 8552; 53348; 29237; 66065; 43185; 64522; 52725 +PAK1 PAK1 Q13153 human PAK1 5058 Q13153 PAK1 human S204 448173 tKsVyTRsVIEPLPV X 2605 +PAK1 PAK1 Q13153 human Snail1 6615 O95863 SNAI1 human S246 455616 QACARTFsRMsLLHK X X +PAK1 PAK1 Q13153 human NET1 56349 Q9Z206 Net1 mouse S538 1868939200 NLRAQRRsCVVPGVM X +PAK1 PAK1 Q13153 human FLNA 2316 P21333 FLNA human S2292 4911900 FEDRkDGsCGVAYVV Filamin X +PAK1 PAK1 Q13153 human RhoGDI alpha 396 P52565 ARHGDIA human S174 452196 kGMLARGsYsIkSRF Rho_GDI X X +PAK1 PAK1 Q13153 human hnRNP E1 5093 Q15365 PCBP1 human T60 478358 NCPERIItLTGPTNA KH_1 X X +PAK1 PAK1 Q13153 human RAF1 110157 Q99N57 Raf1 mouse S338 447742 RPRGQRDssyyWEIE X 9427 +PAK1 PAK1 Q13153 human Cortactin 2017 Q14247 CTTN human S405 447700 KtQtPPVsPAPQPtE X X +PAK1 PAK1 Q13153 human LC8 8655 P63167 DYNLL1 human S88 454241 VAILLFKsG______ Dynein_light X X +PAK1 PAK1 Q13153 human BAD 12015 Q61337 Bad mouse S112 447860 ETRsRHssyPAGtEE Bcl-2_BAD X 9291; 5284; 9296; 5193; 11865; 94223 +PAK1 PAK1 Q13153 human CTBP1 Q9Z2F5 Ctbp1 rat S147 455351 REGTRVQsVEQIREV 2-Hacid_dh_C; 2-Hacid_dh X +PAK1 PAK1 Q13153 human ARL4A 10124 P40617 ARL4A human S143 1877718400 QDLRNSLsLSEIEKL Arf X X +PAK1 PAK1 Q13153 human NLRP3 114548 Q96P20 NLRP3 human S198 230295300 GKTKTCEsPVSPIKM FISNA X +PAK1 PAK1 Q13153 human ARL4D 379 P49703 ARL4D human S144 23083814 QDQPGALsAAEVEkR Arf X X +PAK1 PAK1 Q13153 human SHARP 23013 Q96T58 SPEN human T3568 455622 EGVARRMtVETDYCL SPOC X X +PAK1 PAK1 Q13153 human ARHGEF2 iso2 9181 Q92974-2 ARHGEF2 human S885 451365 PVDPRRRsLPAGDAL X 14143 +PAK1 PAK1 Q13153 human AurA 6790 O14965 AURKA human S342 457608 QETYKRIsRVEFTFP Pkinase X +PAK1 PAK1 Q13153 human STMN1 3925 P16949 STMN1 human S38 448556 sVPEFPLsPPkKkDL Stathmin X 3426; 4191 +PAK1 PAK1 Q13153 human GIT1 28964 Q9Y2X7 GIT1 human S700 465672 PALEPVRsSLRLLNA GIT1_C X +PAK1 PAK1 Q13153 human STAT5A 20850 P42230 Stat5a mouse S779 448750 DsLDARLsPPAGLFT X +PAK1 PAK1 Q13153 human hnRNP E1 5093 Q15365 PCBP1 human T127 478359 IKEIREStGAQVQVA KH_1 X X +PAK1 PAK1 Q13153 human KIF2A iso1 16563 P28740-1 Kif2a mouse T187 50538801 LDYRPLttADPIDEH X +PAK1 PAK1 Q13153 human Merlin 4771 P35240 NF2 human S518 448282 DTDMKRLsMEIEKEK ERM_C X X 9163; 13281 +PAK1 PAK1 Q13153 human Ebp1 5036 Q9UQ80 PA2G4 human T261 2303906 QyGLkMktSRAFFsE Peptidase_M24 X X +PAK1 PAK1 Q13153 human AML2 864 Q13761 RUNX3 human T209 25526800 ERLRMRVtPstPsPr X X +PAK1 PAK1 Q13153 human RhoGDI alpha 396 P52565 ARHGDIA human S101 452195 LEsFKkQsFVLkEGV Rho_GDI X X +PAK1 PAK1 Q13153 human STMN1 3925 P16949 STMN1 human S16 448554 kELEKrAsGQAFELI Stathmin X X 3353 +PAK1 PAK1 Q13153 human MEK1 5604 Q02750 MAP2K1 human S298 448284 RtPGRPLssyGMDSR Pkinase X X 9128; 98195 +PAK1 PAK1 Q13153 human BAD 572 Q92934 BAD human S99 447862 PFrGrsRsAPPNLWA Bcl-2_BAD X X 9295; 5286; 4366 +PAK1 PAK1 Q13153 human KIF2C 11004 Q99661 KIF2C human S111 25159900 kEsLRsRstRMstVS X X +PAK1 PAK1 Q13153 human AurA 6790 O14965 AURKA human T288 448784 APSsRRttLCGtLDy Pkinase X X 3079; 2914; 13464; 8525 +PAK1 PAK1 Q13153 human NET1 56349 Q9Z206 Net1 mouse S153 455601 TPTkRRssALWSEML X +PAK1 PAK1 Q13153 human RAF1 396245 P05625 RAF1 chicken S339 447743 PRGQRDssyyWEIEA X +PAK1 PAK1 Q13153 human SHOT1 71653 Q8K2Q9 Shtn1 mouse S101 4761847 NKTLKRIsMLYMAKL X +PAK1 PAK1 Q13153 human FLNA 192176 Q8BTM8 Flna mouse S2152 451357 TRRRRAPsVANIGsH Filamin X 4761 +PAK1 PAK1 Q13153 human PGM1 5236 P36871 PGM1 human T467 454029 SANDKVYtVEkADNF X X +PAK1 PAK1 Q13153 human PAK1 5058 Q13153 PAK1 human S199 448172 PRPEHtKsVyTRsVI X X 2605 +PAK1 PAK1 Q13153 human RAF1 5894 P04049 RAF1 human S339 447743 PRGQRDssyyWEIEA X +PAK1 PAK1 Q13153 human ILK 3611 Q13418 ILK human S246 479407 CPRLRIFsHPNVLPV PK_Tyr_Ser-Thr X X +PAK1 PAK1 Q13153 human BAD 572 Q92934 BAD human S75 447860 EIRsRHssyPAGtED Bcl-2_BAD X X 9291; 5284; 9296; 5193; 11865; 94223 +PAK1 PAK1 Q13153 human SHOT1 292139 A0MZ67 Shtn1 rat S249 485709 QNKLKRQsHLLLQSS X +PAK1 PAK1 Q13153 human KIF2C 11004 Q99661 KIF2C human S192 2132102 VNsVRRKsCLVkEVE X X +PAK1 PAK1 Q13153 human PGAM1 5223 P18669 PGAM1 human S23 455496 WNLENrFsGWyDADL His_Phos_1 X X +PAK1 PAK1 Q13153 human RhoGDI alpha 396 P52565 ARHGDIA human S176 1876737500 MLARGsYsIkSRFTD Rho_GDI X +PAK1 PAK1 Q13153 human ELF3 1999 P78545 ELF3 human S207 482811 GTGASRSsHSSDsGG X X +PAK1 PAK1 Q13153 human SHOT1 71653 Q8K2Q9 Shtn1 mouse S249 485709 QNkLKRQsHLLLQSS X +PAK1 PAK1 Q13153 human PGAM2 56012 O70250 Pgam2 mouse S118 4698936 QVkIWRRsFDtPPPP His_Phos_1 X X +PAK1 PAK1 Q13153 human MORC2 22880 Q9Y6X9 MORC2 human S739 3217905 AtPsRKRsVAVsDEE X X +PAK1 PAK1 Q13153 human TIE1 21846 Q06806 Tie1 mouse T794 50596802 LHRRRTFtYQSGSGE X +PAK1 PAK1 Q13153 human Cortactin 2017 Q14247 CTTN human S113 465664 skLskHCsQVDsVrG HS1_rep X +PAK1 PAK1 Q13153 human NLRP3 114548 Q96P20 NLRP3 human T659 1871776517 KIEINLStRMDHMVS X X +PAK1 PAK1 Q13153 human BAD 572 Q92934 BAD human S118 447863 GRELRRMsDEFVDsF Bcl-2_BAD X X 9297 +PAK1 PAK1 Q13153 human GIT1 28964 Q9Y2X7 GIT1 human S508 457607 RRDRQAFsMyEPGsA X +PAK1 PAK1 Q13153 human NRIF3 23421 Q13352 ITGB3BP human S28 2840505 SkITRKKsVITysPT CENP-R X X +PAK1 PAK1 Q13153 human BAD 572 Q92934 BAD human S74 5209400 VEIRsRHssyPAGtE Bcl-2_BAD X X +PAK1 PAK1 Q13153 human NLRP3 114548 Q96P20 NLRP3 human S163 409465601 ARLGEsVsLNKRYTR FISNA X +PAK1 PAK1 Q13153 human MRLC1 10398 P24844 MYL9 human S20 1863500 KRPQRAtsNVFAMFD X 3674; 3671; 3675; 95777 +PAK1 PAK1 Q13153 human FLNA 2316 P21333 FLNA human S2152 451357 tRRRRAPsVANVGsH Filamin X X 4761 +PAK1 PAK1 Q13153 human RAF1 396245 P05625 RAF1 chicken S338 447742 RPRGQRDssyyWEIE X +PAK1 PAK1 Q13153 human Snail2 6591 O43623 SNAI2 human S251 63243400 KNCsKTFsRMsLLHK zf-C2H2 X X +PAK1 PAK1 Q13153 human FLNA 2316 P21333 FLNA human S2370 4753817 AIDAkVHsPsGALEE Filamin X +PAK1 PAK1 Q13153 human BRAF 673 P15056 BRAF human S446 447804 KtLGRRDssDDWEIP X 2696 +PAK1 PAK1 Q13153 human MYPT1 116670 Q10728 Ppp1r12a rat T697 448587 ARQSRRstQGVTLTD X 5163 +PAK1 PAK1 Q13153 human PGAM1 5223 P18669 PGAM1 human S118 455497 QVkIWRRsyDVPPPP His_Phos_1 X X +PAK1 PAK1 Q13153 human JUB 16475 Q91XC0 Ajuba mouse T172 22499900 SRPCSNRtSGISMGY X X +PAK1 PAK1 Q13153 human PPP1R14A 114004 Q99MC0 Ppp1r14a rat T38 449098 QKRHARVtVkYDRRE PP1_inhibitor X +PAK1 PAK1 Q13153 human CTNNB1 1499 P35222 CTNNB1 human S552 472273 QDtQRRtsMGGtQQQ X 9566; 5651 +PAK1 PAK1 Q13153 human SHARP 23013 Q96T58 SPEN human S3486 455623 QPAPKQDssPHLTSQ X X +PAK1 PAK1 Q13153 human Cortactin 2017 Q14247 CTTN human S418 447701 tEErLPssPVyEDAA X X +PAK1 PAK1 Q13153 human KIF2A iso1 16563 P28740-1 Kif2a mouse S479 50269506 PHtPFRAsKLtQVLR Kinesin X +PAK1 PAK1 Q13153 human KIF2A iso1 16563 P28740-1 Kif2a mouse S488 31085778 LtQVLRDsFIGENSR Kinesin X +PAK1 PAK1 Q13153 human NET1 56349 Q9Z206 Net1 mouse S152 455600 PTPTkRRssALWSEM X X +PAK1 PAK1 Q13153 human LIMK1 3984 P53667 LIMK1 human T508 447808 PDRKKRYtVVGNPYW PK_Tyr_Ser-Thr X 3841 +PAK1 PAK1 Q13153 human PAK1 5058 Q13153 PAK1 human S144 448170 sNsQKyMsFtDksAE X X 2606 +PAK1 PAK1 Q13153 human RAF1 5894 P04049 RAF1 human S338 447742 RPRGQRDssyyWEIE X X 9427 +PAK1 PAK1 Q13153 human PREX2 80243 Q70Z35 PREX2 human S1107 35483225 DTISNRDsYSDCNSN X +PAK1 PAK1 Q13153 human BAD 12015 Q61337 Bad mouse S136 447862 PFRGRsRsAPPNLWA Bcl-2_BAD X 9295; 5286; 4366 +PAK1 PAK1 Q13153 human ILK 3611 Q13418 ILK human T173 479406 DTFWkGttRTRPRNG X X +PAK1 PAK1 Q13153 human CTBP1 1487 Q13363 CTBP1 human S158 455351 REGTRVQsVEQIREV 2-Hacid_dh_C; 2-Hacid_dh X X +PAK1 PAK1 Q13153 human PAK1 5058 Q13153 PAK1 human T423 448177 PEQSkRstMVGtPYW Pkinase X X 2601 +PAK1 PAK1 Q13153 human MICAL1 64780 Q8TDZ2 MICAL1 human S960 6226101 ELALRRQssSPEQQK bMERB_dom X +PAK1 PAK1 Q13153 human HACE1 57531 Q8IYU2 HACE1 human S385 10940679 LMKNKRDsTEITsIL X +PAK1 PAK1 Q13153 human ER-alpha 2099 P03372 ESR1 human S305 448805 IkRSkkNsLALSLtA X X +PAK1 PAK1 Q13153 human smMLCK 4638 Q15746 MYLK human S1772 1983833 SGLsGRKsstGsPts X +PAK1 PAK1 Q13153 human KIF2A iso1 16563 P28740-1 Kif2a mouse T186 50538800 SLDYRPLttADPIDE X +PAK1 PAK1 Q13153 human ARHGEF7 114559 O55043 Arhgef7 rat T526 455216 EFAVRKStAALEEDA RhoGEF67_u2 X +PAK1 PAK1 Q13153 human BAD 572 Q92934 BAD human S134 447864 KGLPRPKsAGtAtQM Bcl-2_BAD X X +PAK1 PAK1 Q13153 human PAK1 18479 O88643 Pak1 mouse S144 448170 SNSKKYMsFTDKSAE X 2606 +PAK1 PAK1 Q13153 human Vimentin 7431 P08670 VIM human S56 451514 srsLyAssPGGVyAt Filament_head X X 3877; 7391 +PAK1 PAK1 Q13153 human ATG5 9474 Q9H1Y0 ATG5 human T101 23084709 SALPWNItVHFKSFP APG5 X X +TRPM6 ChaK2 Q9BX84 human H4 8359 P62805 H4C1 human S1 448242 _______sGrGkGGk X X +TRPM6 ChaK2 Q9BX84 human H3 8350 P68431 H3C1 human T3 455678 _____ArtkQtArks Histone X 9714; 13576 +TRPM6 ChaK2 Q9BX84 human H2A.1 8329 P0C0S8 H2AC17 human S1 451190 _______sGrGkQGG Histone X X +TRPM6 ChaK2 Q9BX84 human ChaK2 140803 Q9BX84 TRPM6 human T1851 2255402 FNQVKPQtIPYTPRF Alpha_kinase X +TRPM6 ChaK2 Q9BX84 human H3 8350 P68431 H3C1 human T6 13321500 __ArtkQtArkstGG Histone X +Prkg1 PKG1 A9LNM8 rat CHIP 287155 D4A4T0 Stub1 rat S20 453857 LGtGGGGsPDKsPSA X X +Prkg1 PKG1 A9LNM8 rat VASP 7408 P50552 VASP human S239 448380 GAKLRKVsKQEEASG X 3114; 37565 +RPS6KB1 p70S6K iso2 P23443-2 human GSK3B 2932 P49841 GSK3B human S9 449111 SGRPRttsFAEsCkP X 9336; 9331; 9327; 9323; 9322; 9325; 5558; 8566; 79774; 8466; 25462; 14026; 14332; 14310; 14630 +RPS6KB1 p70S6K iso2 P23443-2 human EPRS 2058 P07814 EPRS1 human S999 9720900 NQGGGLsssGAGEGQ X +WNK1 WNK1 Q9H4A3 human PCF11 51585 O94913 PCF11 human S120 397383603 KSLFKLRstWDEIFP CID X X +WNK1 WNK1 Q9H4A3 human WNK1 65125 Q9H4A3 WNK1 human S382 454105 kRAsFAKsVIGTPEF Pkinase X X +WNK1 WNK1 Q9H4A3 human OSR1 108737 Q6P9R2 Oxsr1 mouse S325 456504 VRRVPGssGRLHKtE X +WNK1 WNK1 Q9H4A3 human KCC3 9990 Q9UHW9 SLC12A6 human T991 4770536 SAYTYERtLMMEQRS SLC12 X +WNK1 WNK1 Q9H4A3 human STLK3 53416 Q9Z1W9 Stk39 mouse T243 456505 tRNKVRKtFVGtPCW Pkinase X +WNK1 WNK1 Q9H4A3 human OSR1 9943 O95747 OXSR1 human S325 456504 VRRVPGssGRLHKtE X +WNK1 WNK1 Q9H4A3 human OSR1 9943 O95747 OXSR1 human T185 456503 TRNKVRktFVGtPCW Pkinase X +WNK1 WNK1 Q9H4A3 human KCC3 9990 Q9UHW9 SLC12A6 human T1048 4770548 YQEKVHMtWTKDKYM SLC12 X +WNK1 WNK1 Q9H4A3 human STLK3 27347 Q9UEW8 STK39 human T231 456505 tRNKVRktFVGtPCW Pkinase X +WNK1 WNK1 Q9H4A3 human PCF11 51585 O94913 PCF11 human T121 397383604 SLFKLRstWDEIFPL CID X X +WNK1 WNK1 Q9H4A3 human STLK3 27347 Q9UEW8 STK39 human S371 456506 VRRVPGssGHLHKTE X +INSR INSR P06213 human IRS1 3667 P35568 IRS1 human Y989 451287 VPssRGDyMTMQMSC X +INSR INSR P06213 human INSR iso2 3643 P06213-2 INSR human Y1173 447680 FGMTRDIyETDyyRK PK_Tyr_Ser-Thr X +INSR INSR P06213 human INSR iso2 3643 P06213-2 INSR human S1302 447677 EENKAPEsEELEMEF X +INSR INSR P06213 human GAB1 2549 Q13480 GAB1 human Y242 455030 FFQQQMIyDsPPSRA X +INSR INSR P06213 human BVR 644 P53004 BLVRA human Y291 455760 LAEEIQkyCCSRK__ X +INSR INSR P06213 human PTEN 5728 P60484 PTEN human Y174 464091 TIPSQRRyVyyysyL X +INSR INSR P06213 human Calmodulin 24242 P0DP29 Calm3 rat Y100 448707 FDkDGNGyIsAAELR EF-hand_7 X +INSR INSR P06213 human ADRB2 101836719 P04274 Adrb2 hamster Y350 449808 RRSSSKAyGNGySSN X +INSR INSR P06213 human PIK3R3 8503 Q92569 PIK3R3 human Y341 451553 NEDADENyFINEEDE X X +INSR INSR P06213 human INSR 3643 P06213 INSR human S1348 447678 GGRDGGSsLGFkRsy X +INSR INSR P06213 human CNGA1 281700 Q00194 CNGA1 cow Y503 27166602 QVySPGDyICKKGDI cNMP_binding X X +INSR INSR P06213 human STXBP3 20912 Q60770 Stxbp3 mouse Y521 459181 RQKPRTNyLELDRKN Sec1 X +INSR INSR P06213 human CEACAM1 81613 P16573 Ceacam1 rat Y488 447777 NKVDDVSySVLNFNA X +INSR INSR P06213 human INSR iso2 3643 P06213-2 INSR human Y1343 447683 sLGFKRSyEEHIPyT X +INSR INSR P06213 human IRS1 3667 P35568 IRS1 human Y896 447556 EPKsPGEyVNIEFGS X 3070 +INSR INSR P06213 human Calmodulin 24242 P0DP29 Calm3 rat Y139 448708 DGDGQVNyEEFVQMM EF-hand_7 X +INSR INSR P06213 human DOK1 1796 Q99704 DOK1 human Y362 448367 DPKEDPIyDEPEGLA X +INSR INSR P06213 human STAT5B 20851 P42232 Stat5b mouse Y699 448198 TAkAADGyVKPQIKQ X 9365; 9356; 9359; 9351; 4322; 9314; 3939; 40284; 5387; 14603; 66740; 51879; 72712 +INSR INSR P06213 human PTEN 5728 P60484 PTEN human Y27 34668100 GFDLDLTyIYPNIIA X +INSR INSR P06213 human IRS2 384783 P81122 Irs2 mouse Y628 457098 YNPyPEDyGDIEIGs X +INSR INSR P06213 human GAB1 2549 Q13480 GAB1 human Y659 447949 VADERVDyVVVDQQK X 12745 +INSR INSR P06213 human GAB1 2549 Q13480 GAB1 human Y373 447945 AsDtDssyCIPTAGM X +INSR INSR P06213 human INSR 3643 P06213 INSR human Y999 447685 yASSNPEyLSASDVF X +INSR INSR P06213 human IRS1 3667 P35568 IRS1 human Y1179 451288 GLENGLNyIDLDLVk X +INSR INSR P06213 human INSR 3643 P06213 INSR human S1314 447677 EENKAPEsEELEMEF X +INSR INSR P06213 human GAB1 2549 Q13480 GAB1 human Y589 449792 SHDSEENyVPMNPNL X +INSR INSR P06213 human PPP2CA 5515 P67775 PPP2CA human Y307 448571 VTRRtPDyFl_____ X +INSR INSR P06213 human INSR 3643 P06213 INSR human Y1355 447683 sLGFkRsyEEHIPyt X 3026 +INSR INSR P06213 human INSR 3643 P06213 INSR human Y1189 447681 RDIyEtDyyRkGGkG PK_Tyr_Ser-Thr X 3024; 3918; 2969 +INSR INSR P06213 human ADRB2 101836719 P04274 Adrb2 hamster Y354 449809 SKAyGNGySSNSNGK X +INSR INSR P06213 human BVR 644 P53004 BLVRA human Y198 455758 EERKEDQyMKMtVCL Biliv-reduc_cat X +INSR INSR P06213 human IRS2 384783 P81122 Irs2 mouse Y624 3597307 PKVAYNPyPEDyGDI X +INSR INSR P06213 human SOCS3 12702 O35718 Socs3 mouse Y204 450446 VNGHLDSyEKVTQLP X +INSR INSR P06213 human BVR 644 P53004 BLVRA human Y228 455759 PGLKRNRyLsFHFks Biliv-reduc_cat X +INSR INSR P06213 human PIK3R1 5295 P27986 PIK3R1 human Y607 448136 NENtEDQysLVEDDE X +INSR INSR P06213 human ARHGAP5 394 Q13017 ARHGAP5 human Y306 449920 NHPDYEEyINLEGTR RhoGAP-FF1 X +INSR INSR P06213 human DOK1 1796 Q99704 DOK1 human Y398 448369 ARVkEEGyELPyNPA X +INSR INSR P06213 human INSR iso2 3643 P06213-2 INSR human Y1177 447681 RDIyETDyyRKGGKG PK_Tyr_Ser-Thr X 3918; 2969 +INSR INSR P06213 human CNGA1 281700 Q00194 CNGA1 cow Y498 450319 LKLQPQVySPGDyIC cNMP_binding X X +INSR INSR P06213 human GAB1 2549 Q13480 GAB1 human Y447 449791 SEELDENyVPMNPNs X +INSR INSR P06213 human GAB1 2549 Q13480 GAB1 human Y472 447947 EPIQEANyVPMtPGT X +INSR INSR P06213 human INSR 3643 P06213 INSR human Y992 451597 DGPLGPLyASSNPEy X +INSR INSR P06213 human INSR iso2 3643 P06213-2 INSR human Y1349 447684 SyEEHIPyTHMNGGK X +INSR INSR P06213 human INSR iso2 3643 P06213-2 INSR human Y1178 447682 DIyETDyyRKGGKGL PK_Tyr_Ser-Thr X 2969 +INSR INSR P06213 human SHP-1 5777 P29350 PTPN6 human Y536 448506 QkGQEsEyGNItyPP X X +INSR INSR P06213 human PHB 5245 P35232 PHB1 human Y114 6374001 FtsIGEDyDERVLPs Band_7 X +INSR INSR P06213 human PIK3R1 5295 P27986 PIK3R1 human Y368 448134 STKMHGDytLTLRKG SH2 X +INSR INSR P06213 human Daple 440193 Q9P219 CCDC88C human Y2025 899136400 PQTVWyEyGCV____ X +INSR INSR P06213 human ADRB2 101836719 P04274 Adrb2 hamster Y364 449810 NSNGKTDyMGEASGC X X +INSR INSR P06213 human IkB-alpha 4792 P25963 NFKBIA human Y42 448737 DsMkDEEyEQMVkEL X +INSR INSR P06213 human GAB1 2549 Q13480 GAB1 human Y285 449801 TEADGELyVFNTPSG X +INSR INSR P06213 human INSR iso2 3643 P06213-2 INSR human S1336 447678 GGRDGGSsLGFKRSy X +INSR INSR P06213 human INSR 3643 P06213 INSR human Y1011 449048 DVFPCSVyVPDEWEV X +INSR INSR P06213 human INSR 3643 P06213 INSR human Y1361 447684 syEEHIPytHMNGGK X 3023 +INSR INSR P06213 human ADRB2 101836719 P04274 Adrb2 hamster Y141 449832 AITSPFKyQSLLTKN 7tm_1 X +INSR INSR P06213 human ADRB2 101836719 P04274 Adrb2 hamster Y132 449831 CVIAVDRyIAITSPF 7tm_1 X +INSR INSR P06213 human PIK3R1 5295 P27986 PIK3R1 human Y580 448135 LRKtRDQyLMWLTQK PI3K_P85_iSH2 X +INSR INSR P06213 human INSR 3643 P06213 INSR human Y1185 447680 FGMTRDIyEtDyyRk PK_Tyr_Ser-Thr X 3021; 80732 +INSR INSR P06213 human GAB1 2549 Q13480 GAB1 human Y627 447948 KGDKQVEyLDLDLDs X 3231; 3233 +INSR INSR P06213 human INSR 3643 P06213 INSR human Y1190 447682 DIyEtDyyRkGGkGL PK_Tyr_Ser-Thr X 3024; 2969 +Musk MUSK Q62838 rat MUSK Q62838 Musk rat Y812 2848303 MAHEEVIyYVRDGNI PK_Tyr_Ser-Thr X +Musk MUSK Q62838 rat MUSK Q62838 Musk rat Y754 2848302 RNIySADyyKADGND PK_Tyr_Ser-Thr X +Musk MUSK Q62838 rat MUSK Q62838 Musk rat Y576 2848301 YPRNNIEyVRDIGEG PK_Tyr_Ser-Thr X +Musk MUSK Q62838 rat MUSK Q62838 Musk rat Y755 2848300 NIySADyyKADGNDA PK_Tyr_Ser-Thr X +Musk MUSK Q62838 rat MUSK Q62838 Musk rat Y553 2848304 RLHPNPMyQRMPLLL X +MAP3K8 Cot P41279 human Radixin 5962 P35241 RDX human T564 448374 AGRDKyKtLRQIRQG ERM_C X 3141; 3726; 32600 +MAP3K8 Cot P41279 human PLCB3 18797 P51432 Plcb3 mouse S537 448450 TSLEPQKsLGEEsLS X 2481; 29021 +MAP3K8 Cot P41279 human IRF3 3661 Q14653 IRF3 human T180 28095000 sPsLDNPtPFPNLGP X +MAP3K8 Cot P41279 human Ezrin 7430 P15311 EZR human T567 448104 QGRDkyKtLRQIRQG ERM_C X 3141; 3726; 32600 +MAP3K8 Cot P41279 human Abl 25 P00519 ABL1 human T735 450291 DTEWRSVtLPRDLQS X 2864 +MAP3K8 Cot P41279 human MEK1 5604 Q02750 MAP2K1 human S222 448513 LIDsMANsFVGtRSY Pkinase X X 2338; 9121; 3958; 9154; 16211; 86128; 16780; 75262 +MAP3K8 Cot P41279 human p90RSK 6195 Q15418 RPS6KA1 human S380 447990 HQLFRGFsFVAtGLM Pkinase_C X 9341; 9335; 13575; 11989; 12032; 75266; 93317; 13397; 13588 +MAP3K8 Cot P41279 human CDK1 983 P06493 CDK1 human T161 447609 GIPIRVytHEVVTLW Pkinase X 9114 +MAP3K8 Cot P41279 human MEK1 5604 Q02750 MAP2K1 human S218 448514 VsGQLIDsMANsFVG Pkinase X X 9121; 3958; 9154; 86128 +MAP3K8 Cot P41279 human PLK1 5347 P53350 PLK1 human S137 448138 LELCRRRsLLELHkR Pkinase X X +MAP3K8 Cot P41279 human IRF3 3661 Q14653 IRF3 human S175 14567912 PQPLRsPsLDNPtPF X +MAP3K8 Cot P41279 human Chk1 1111 O14757 CHEK1 human S345 447834 LVQGIsFsQPtCPDH X 2341; 2348; 12268; 76784 +MAP3K8 Cot P41279 human MEK2 5605 P36507 MAP2K2 human S222 448073 VsGQLIDsMANsFVG Pkinase X X 9121; 3958; 9154; 86128 +MAP3K8 Cot P41279 human NPM1 4869 P06748 NPM1 human T199 448515 VkKsIrDtPAkNAQK X X 3541; 75984 +MAP3K8 Cot P41279 human IRF3 3661 Q14653 IRF3 human S123 4712212 DFSQPDTsPDTNGGG X +MAP3K8 Cot P41279 human MKK3 5606 P46734 MAP2K3 human S218 448276 IsGyLVDsVAKtMDA Pkinase X 9231; 9236; 12280 +MAP3K8 Cot P41279 human CREB 1385 P16220 CREB1 human S119 448228 EILsRRPsyRkILND pKID X 9187; 9196; 9198; 4095; 14228; 14001; 39561; 80120; 44864; 54960; 95995 +MAP3K8 Cot P41279 human eIF4G 1981 Q04637 EIF4G1 human S1147 449800 VVQRssLsRERGEKA X 2441 +MAP3K8 Cot P41279 human MKK6 5608 P52564 MAP2K6 human S207 448194 IsGyLVDsVAKtIDA Pkinase X 9231; 12280 +MAP3K8 Cot P41279 human 4E-BP1 1978 Q13541 EIF4EBP1 human T70 447528 rNsPVtktPPRDLPt eIF_4EBP X 9455; 13396 +MAP3K8 Cot P41279 human PLK1 5347 P53350 PLK1 human T210 448139 YDGERKktLCGtPNy Pkinase X 4354; 5472; 9062 +MAP3K8 Cot P41279 human Cot 26410 Q07174 Map3k8 mouse S141 467688 LTYRNIGsGFVPRGA Pkinase X +MAP3K8 Cot P41279 human Moesin 4478 P26038 MSN human T558 447706 LGRDKyKtLRQIRQG ERM_C X 3141; 3726; 32600 +MAP3K8 Cot P41279 human IRF3 3661 Q14653 IRF3 human S188 30312501 PFPNLGPsENPLkRL X +MAP3K8 Cot P41279 human MEK2 5605 P36507 MAP2K2 human S226 448074 LIDsMANsFVGtRSY Pkinase X X 2338; 9121; 3958; 9154; 16211; 86128; 16780; 75262 +MAP3K8 Cot P41279 human Cot 26410 Q07174 Map3k8 mouse S443 478514 EVLRRQRsLYIDLGA X +MAP3K8 Cot P41279 human H2B 3018 P33778 H2BC3 human S32 447801 DGKkRKRsRkEsysI Histone X +MAP3K8 Cot P41279 human IRF3 3661 Q14653 IRF3 human S173 6370303 PCPQPLRsPsLDNPt X +Rps6ka3 RSK2 P18654 mouse MASTL 67121 Q8C0P0 Mastl mouse T297 1269647500 QCRKRLGtSSTSSQS X +Rps6ka3 RSK2 P18654 mouse H3 360198 P68433 H3c1 mouse S10 455676 tkQTARkstGGkAPr Histone X X 9701; 9711; 9606; 3465; 3642; 3377; 3475; 3458; 5764; 47398; 8481; 8552; 53348; 29237; 66065; 43185; 64522; 52725 +Rps6ka3 RSK2 P18654 mouse H3 8350 P68431 H3C1 human S10 455676 tkQtArkstGGkAPr Histone X 9701; 9711; 9606; 3465; 3642; 3377; 3475; 3458; 5764; 47398; 8481; 8552; 53348; 29237; 66065; 43185; 64522; 52725 +Rps6ka3 RSK2 P18654 mouse Fos 14281 P01101 Fos mouse S362 448481 AAAHRKGsSSNEPSS X +Rps6ka3 RSK2 P18654 mouse CASP8 12370 O89110 Casp8 mouse T265 21258500 KMKDRKGtDCDKEAL Peptidase_C14 X +Rps6ka3 RSK2 P18654 mouse BAD 12015 Q61337 Bad mouse S112 447860 ETRsRHssyPAGtEE Bcl-2_BAD X X 9291; 5284; 9296; 5193; 11865; 94223 +Rps6ka3 RSK2 P18654 mouse ATF-4 11911 Q06507 Atf4 mouse S251 451447 NLPsPGGsRGSPRPK X X +Rps6ka3 RSK2 P18654 mouse p27Kip1 1027 P46527 CDKN1B human T198 448781 PGLRRRQt_______ X X +Rps6ka3 RSK2 P18654 mouse H3 iso3 15081 P84244 H3f3b mouse S10 455676 tKQTARksTGGkAPR Histone X 9701; 9711; 9706; 3465; 3642; 3377; 3475; 3458; 5764; 47398; 8481; 8552; 53348; 29237; 66065; 43185; 64522; 52725 +Rps6ka3 RSK2 P18654 mouse p27Kip1 1027 P46527 CDKN1B human S10 447874 NVRVSNGsPsLErMD X +Rps6ka3 RSK2 P18654 mouse TRAF6 22034 P70196 Traf6 mouse S46 1040254704 SASTGNLsssFMEEI X +Rps6ka3 RSK2 P18654 mouse TRAF6 22034 P70196 Traf6 mouse S48 1040254702 STGNLsssFMEEIQG X +Rps6ka3 RSK2 P18654 mouse MYBPC3 295929 P56741 Mybpc3 rat S288 471080 AGTGRRtsDSHEDAG X +Rps6ka3 RSK2 P18654 mouse HMGN1 15312 P18608 Hmgn1 mouse S7 465531 _MPKRKVsADGAAkA HMG14_17 X +Rps6ka3 RSK2 P18654 mouse RSK2 110651 P18654 Rps6ka3 mouse S386 448065 HQLFRGFsFVAITSD Pkinase_C X 9341; 9335; 13575; 11989; 12032; 75266; 93317; 13397; 13588 +Rps6ka3 RSK2 P18654 mouse C/EBP-beta 24253 P21272 Cebpb rat S273 13373502 QKKVEQLsRELSTLR bZIP_2 X +Rps6ka3 RSK2 P18654 mouse TRAF6 22034 P70196 Traf6 mouse S47 1040254703 ASTGNLsssFMEEIQ X +NUAK2 NuaK2 Q9H093 human LATS1 9113 O95835 LATS1 human S464 451855 NIPVRsNsFNNPLGN X +MAPK9 JNK2 P45984 human YAP1 iso3 10413 P46937-3 YAP1 human T154 3190681 VVSGPAAtPTAQHLR X +MAPK9 JNK2 P45984 human Tau iso8 4137 P10636-8 MAPT human T231 449079 KKVAVVRtPPKsPss X 20473; 71429 +MAPK9 JNK2 P45984 human ATF-2 1386 P15336 ATF2 human T69 448224 sVIVADQtPtPtRFL X X 9225; 94125; 40749; 61584; 44167 +MAPK9 JNK2 P45984 human APP iso4 351 P05067-4 APP human T668 448523 VEVDAAVtPEERHLs APP_amyloid X +MAPK9 JNK2 P45984 human ATF-2 1386 P15336 ATF2 human T71 448225 IVADQtPtPtRFLkN X X 9225; 9221; 5112; 94125; 13850; 40749; 15411; 24329; 61584; 27934; 92109; 20534; 35858 +MAPK9 JNK2 P45984 human JDP2 122953 Q8WYK2 JDP2 human T148 448312 VRtDsVKtPEsEGNP X +MAPK9 JNK2 P45984 human KLF13 51621 Q9Y2Y9 KLF13 human S119 40721820 GAAAAPPsPAWsEPE X +MAPK9 JNK2 P45984 human TOB1 10140 P50616 TOB1 human S154 455536 SSVSSsPsPPFGHSA X +MAPK9 JNK2 P45984 human YAP1 iso3 10413 P46937-3 YAP1 human T119 4959542 AGTAGALtPQHVRAH X +MAPK9 JNK2 P45984 human CTNNB1 12387 Q02248 Ctnnb1 mouse S191 467710 SRHAIMRsPQMVSAI X X +MAPK9 JNK2 P45984 human NFAT3 4776 Q14934 NFATC4 human S217 953803 GLGsPLPsPRAsPRP X +MAPK9 JNK2 P45984 human KLF13 51621 Q9Y2Y9 KLF13 human S123 40721822 APPsPAWsEPEPEAG X +MAPK9 JNK2 P45984 human GR 24413 P06536 Nr3c1 rat S246 451796 LIDENLLsPLAGEDD GCR X 97285 +MAPK9 JNK2 P45984 human PDX1 3651 P52945 PDX1 human S66 458402 QGsPPDIsPYEVPPL X +MAPK9 JNK2 P45984 human LIMD1 8994 Q9UGP4 LIMD1 human S277 451975 RVsPGLPsPNLENGA X X +MAPK9 JNK2 P45984 human LIMD1 8994 Q9UGP4 LIMD1 human S272 451974 TASsQRVsPGLPsPN X X +MAPK9 JNK2 P45984 human Bcl-xL 598 Q07817 BCL2L1 human T115 448162 LTSQLHItPGTAYQS Bcl-2 X +MAPK9 JNK2 P45984 human ATF-2 1386 P15336 ATF2 human S90 467297 GLFNELAsPFENEFk X +MAPK9 JNK2 P45984 human p53 7157 P04637 TP53 human S46 447536 AMDDLMLsPDDIEQW TAD2 X 2521 +MAPK9 JNK2 P45984 human WSTF 9031 Q9UIG0 BAZ1B human S158 3215310 ksDGACDsPssDKEN X +MAPK9 JNK2 P45984 human CDC25C 995 P30307 CDC25C human S168 449022 SEMKyLGsPIttVPK X X +MAPK9 JNK2 P45984 human SERT 6532 P31645 SLC6A4 human T616 7576402 IKsItPEtPTEIPCG X +MAPK9 JNK2 P45984 human YAP1 iso3 10413 P46937-3 YAP1 human S317 471290 GTQNPVSsPGMSQEL X +MAPK9 JNK2 P45984 human BID 637 P55957 BID human T59 448406 EGyDELQtDGNRsSH BID X X +MAPK9 JNK2 P45984 human LIMD1 8994 Q9UGP4 LIMD1 human S421 3214989 LGSVLLDsPssPRVr X X +MAPK9 JNK2 P45984 human PIN1 5300 Q13526 PIN1 human S115 1873647702 sQFSDCssAkARGDL Rotamase X +MAPK9 JNK2 P45984 human PSEN1 5663 P49768 PSEN1 human S319 3397301 NskyNAEstEREsQD Presenilin X X +MAPK9 JNK2 P45984 human Doublecortin iso2 1641 O43602-2 DCX human T321 451361 TSSSQLStPKSKQsP X +MAPK9 JNK2 P45984 human SH3BP5 117186 Q91Y80 Sh3bp5 rat S353 456020 PGSLDLPsPVSLSEF X +MAPK9 JNK2 P45984 human NFAT4 4775 Q12968 NFATC3 human S163 448857 SYRESSLsPsPASSI X X +MAPK9 JNK2 P45984 human Bcl-xL 598 Q07817 BCL2L1 human S62 449099 PSWHLADsPAVNGAT X +MAPK9 JNK2 P45984 human Doublecortin iso2 1641 O43602-2 DCX human S334 451359 sPIStPTsPGSLRkH X 3453; 14053 +MAPK9 JNK2 P45984 human p21Cip1 1026 P38936 CDKN1A human S98 478193 GGRRPGTsPALLQGT X +MAPK9 JNK2 P45984 human IRX3 16373 P81067 Irx3 mouse S389 1874748506 APPTLQLsPAAAAAA X +MAPK9 JNK2 P45984 human BNIP3 84480 Q9ET45 Bnip3 rat T66 4698307 DsPPRSQtPQDTNRA BNIP3 X +MAPK9 JNK2 P45984 human FOXO4 4303 P98177 FOXO4 human T451 448518 PIPKALGtPVLtPPt X +MAPK9 JNK2 P45984 human ATF-2 11909 P16951 Atf2 mouse T51 448224 sVIVADQtPtPtRFL X 9225; 94125; 40749; 61584; 44167 +MAPK9 JNK2 P45984 human SREBP-1 6720 P36956 SREBF1 human S117 469986 YPSMPAFsPGPGIkE X +MAPK9 JNK2 P45984 human GRASP65 64689 Q9BQQ3 GORASP1 human S274 455582 DPLPGPGsPSHsAPD X +MAPK9 JNK2 P45984 human BIM 12125 O54918 Bcl2l11 mouse S65 449330 GPLAPPAsPGPFATR X 4581; 4585 +MAPK9 JNK2 P45984 human Doublecortin iso2 1641 O43602-2 DCX human T331 469976 SKQsPIStPTsPGSL X +MAPK9 JNK2 P45984 human Tau iso8 4137 P10636-8 MAPT human S202 447928 sGyssPGsPGtPGsR X 39357; 30505 +MAPK9 JNK2 P45984 human Myc 4609 P01106 MYC human S86 449991 sRRsGLCsPSyVAVt Myc_N X +MAPK9 JNK2 P45984 human PSEN1 5663 P49768 PSEN1 human T320 3397302 skyNAEstEREsQDT Presenilin X X +MAPK9 JNK2 P45984 human p21Cip1 1026 P38936 CDKN1A human S130 455618 sGEQAEGsPGGPGDs X +MAPK9 JNK2 P45984 human RXRA 6256 P19793 RXRA human S260 450891 NMGLNPssPNDPVtN Hormone_recep X +MAPK9 JNK2 P45984 human YAP1 iso3 10413 P46937-3 YAP1 human S138 485036 SLQLGAVsPGTLTPT X +MAPK9 JNK2 P45984 human Bcl-xL 598 Q07817 BCL2L1 human T47 448163 GTESEMEtPsAINGN X +MAPK9 JNK2 P45984 human TOB1 10140 P50616 TOB1 human S152 455535 PASSVSSsPsPPFGH X +MAPK9 JNK2 P45984 human Tau iso8 4137 P10636-8 MAPT human T217 449078 sRtPsLPtPPtREPK X 33134; 51625 +MAPK9 JNK2 P45984 human BNIP3 84480 Q9ET45 Bnip3 rat S60 17548869 SKSSHCDsPPRSQtP BNIP3 X +MAPK9 JNK2 P45984 human IRX3 16373 P81067 Irx3 mouse S361 1874748504 SLAETATsPDNPRRS X +MAPK9 JNK2 P45984 human NFAT3 4776 Q14934 NFATC4 human S213 953804 ASRFGLGsPLPsPRA X +MAPK9 JNK2 P45984 human NFAT4 4775 Q12968 NFATC3 human S165 448858 RESSLsPsPASSISs X X +MAPK9 JNK2 P45984 human CBX7 52609 Q8VDS3 Cbx7 mouse T119 29669800 TNGPPPWtPTLPSSE CBX7_C X +MAPK9 JNK2 P45984 human Jun 3725 P05412 JUN human S73 447943 VGLLkLAsPELERLI Jun X X 9164; 3270; 8752; 12714; 77955 +MAPK9 JNK2 P45984 human Jun 16476 P05627 Jun mouse S63 447686 kNsDLLtsPDVGLLK Jun X 5464; 9261; 2361; 97721; 91952 +MAPK9 JNK2 P45984 human STMN1 16765 P54227 Stmn1 mouse S38 448556 sVPdFPLsPPKKKDL Stathmin X 3426; 4191 +MAPK9 JNK2 P45984 human p53 7157 P04637 TP53 human S20 447529 PLsQEtFsDLWkLLP P53_TAD X X 9287 +MAPK9 JNK2 P45984 human Tau iso8 4137 P10636-8 MAPT human T181 447932 ktPPAPktPPssGEP X 12885; 66224; 62672 +MAPK9 JNK2 P45984 human HES1 29577 Q04666 Hes1 rat S263 23298200 SVGPNAVsPSSGSSL X +MAPK9 JNK2 P45984 human MAPKAPK5 8550 Q8IW41 MAPKAPK5 human T182 450093 IDQGDLMtPQFtPyY Pkinase X +MAPK9 JNK2 P45984 human MARCKS 4082 P29966 MARCKS human S46 454165 VKVNGDAsPAAAEsG MARCKS X +MAPK9 JNK2 P45984 human Jun 3725 P05412 JUN human S63 447686 kNsDLLtsPDVGLLk Jun X X 5464; 9261; 2361; 97721; 91952 +MAPK9 JNK2 P45984 human ATF-2 11909 P16951 Atf2 mouse T53 448225 IVADQtPtPtRFLKN X 9225; 9221; 5112; 94125; 13850; 40749; 15411; 24329; 61584; 27934; 92109; 20534; 35858 +MAPK9 JNK2 P45984 human SHC1 20416 P98083 Shc1 mouse S36 448508 TPPEELPsPSASSLG X +MAPK9 JNK2 P45984 human Myc 4609 P01106 MYC human S77 448586 LLPtPPLsPsRRsGL Myc_N X 13748 +MAPK9 JNK2 P45984 human CDK4 1019 P11802 CDK4 human T172 448476 YSYQMALtPVVVTLW Pkinase X +MAPK9 JNK2 P45984 human STMN1 16765 P54227 Stmn1 mouse S25 448555 QAFELILsPRskEsV Stathmin X +MAPK9 JNK2 P45984 human PDX1 3651 P52945 PDX1 human S61 458401 LGALEQGsPPDIsPY X +MAPK9 JNK2 P45984 human Tau iso8 4137 P10636-8 MAPT human T212 447934 tPGsRsRtPsLPtPP X +MAPK9 JNK2 P45984 human Oct4 18999 P20263 Pou5f1 mouse S347 25236701 VPVtALGsPMHSN__ X +MAPK9 JNK2 P45984 human CTNNB1 12387 Q02248 Ctnnb1 mouse S605 3545003 LFVQLLYsPIENIQR Arm X X +MAPK9 JNK2 P45984 human TAB1 10454 Q15750 TAB1 human S438 456224 tPTLTNQsPTLtLQS X +MAPK9 JNK2 P45984 human JIP1 9479 Q9UQF2 MAPK8IP1 human T103 449924 LIDAtGDtPGAEDDE X +MAPK9 JNK2 P45984 human LIMD1 8994 Q9UGP4 LIMD1 human S424 3214995 VLLDsPssPRVrLPC X X +MAPK9 JNK2 P45984 human IP3R1 16438 P11881 Itpr1 mouse S1755 450682 RPSGRREsLtsFGNG X 3760; 8548 +MAPK9 JNK2 P45984 human TOB1 10140 P50616 TOB1 human S164 455537 FGHSAAVsPTFMPRS X +MAPK9 JNK2 P45984 human FOXO4 4303 P98177 FOXO4 human T455 448570 ALGtPVLtPPtEAAS X +MAPK9 JNK2 P45984 human GRASP65 56082 O35254 Gorasp1 rat S277 455582 EQLPGPGsPGHGTAD X X +MAPK9 JNK2 P45984 human TIF1A 54700 Q9NYV6 RRN3 human T200 455599 IARYVPstPWFLMPI RRN3 X +MAPK9 JNK2 P45984 human p21Cip1 1026 P38936 CDKN1A human T57 451222 NFDFVtEtPLEGDFA CDI X +MAPK9 JNK2 P45984 human YAP1 iso3 10413 P46937-3 YAP1 human T362 23939103 SSySVPRtPDDFLNS X X +MAPK9 JNK2 P45984 human APLP2 334 Q06481 APLP2 human T736 451599 VEVDPMLtPEERHLN APP_amyloid X +LATS2 LATS2 Q9NRM7 human YAP1 10413 P46937 YAP1 human S397 3190672 tyHSRDEstDsGLsM X X +LATS2 LATS2 Q9NRM7 human p21Cip1 1026 P38936 CDKN1A human S146 447836 GRkRRQtsMTDFyHs X X +LATS2 LATS2 Q9NRM7 human YAP1 22601 P46938 Yap1 mouse S382 3190672 TyHSRDEstDsGLSM X 13619 +LATS2 LATS2 Q9NRM7 human Snail2 6591 O43623 SNAI2 human T208 25311911 QGHIRtHtGEkPFSC X X +LATS2 LATS2 Q9NRM7 human MTF1 4520 Q14872 MTF1 human S152 50784002 EGCPRTysTAGNLRT zf-C2H2 X +LATS2 LATS2 Q9NRM7 human AMOTL2 51421 Q9Y2J4 AMOTL2 human S159 29674704 HGHVRsLsERLLQLs X +LATS2 LATS2 Q9NRM7 human AMOT 27494 Q8VHG2 Amot mouse S176 28699604 QGHVRSLsERLMQMs X +LATS2 LATS2 Q9NRM7 human YAP1 iso2 10413 P46937-2 YAP1 human S109 452305 KsHsRQAstDAGtAG X 46931; 53749 +LATS2 LATS2 Q9NRM7 human YAP1 10413 P46937 YAP1 human S127 448847 PQHVRAHssPAsLQL X 4911; 13008; 92367; 57706 +LATS2 LATS2 Q9NRM7 human TAZ 97064 Q9EPK5 Wwtr1 mouse S89 457660 AQHVRSHssPAsLQL X 75275; 59971 +LATS2 LATS2 Q9NRM7 human YAP1 iso2 10413 P46937-2 YAP1 human S127 448847 PQHVRAHssPASLQL X X 57706 +LATS2 LATS2 Q9NRM7 human YAP1 10413 P46937 YAP1 human S109 452305 ksHsRQAstDAGtAG X 46931; 53749 +LATS2 LATS2 Q9NRM7 human YAP1 iso2 10413 P46937-2 YAP1 human S381 3190672 TYHSRDEsTDsGLsM X 13619 +LATS2 LATS2 Q9NRM7 human TAZ 25937 Q9GZV5 WWTR1 human S89 457660 AQHVRsHssPAsLQL X 75275; 59971 +LATS2 LATS2 Q9NRM7 human Snail1 6615 O95863 SNAI1 human T203 21400402 QGHVRtHtGEkPFSC X X +LATS2 LATS2 Q9NRM7 human INCENP 3619 Q9NQS7 INCENP human S894 450468 RYHKRtssAVWNsPP X +LATS2 LATS2 Q9NRM7 human YAP1 22601 P46938 Yap1 mouse S112 448847 PQHVRAHssPAsLQL X 4911; 13008; 92367; 57706 +LATS2 LATS2 Q9NRM7 human Abl iso2 25 P00519-2 ABL1 human T197 12121095 VYHYRINtASDGKLy SH2 X X +LATS2 LATS2 Q9NRM7 human LATS2 26524 Q9NRM7 LATS2 human S835 28706304 GSHVRQDsMEPSDLW Pkinase X +LATS2 LATS2 Q9NRM7 human CDC26 246184 Q8NHZ8 CDC26 human T7 10815632 _MLRRKPtRLELKLD ANAPC_CDC26 X X +LATS2 LATS2 Q9NRM7 human Raptor 57521 Q8N122 RPTOR human S606 53407301 SAHEkLYsLLSDPIP HEAT X +LATS2 LATS2 Q9NRM7 human PQBP1 10084 O60828 PQBP1 human S247 3175780 FQQRPYPsPGAVLRA X X +LATS2 LATS2 Q9NRM7 human YAP1 iso2 10413 P46937-2 YAP1 human S61 484116 IVHVRGDsEtDLEAL X +LATS2 LATS2 Q9NRM7 human PRPS1 5631 P60891 PRPS1 human S285 1874748500 EDkMKHCsKIQVIDI Pribosyl_synth X X +LATS2 LATS2 Q9NRM7 human 14-3-3 gamma 7532 P61981 YWHAG human S59 3892745 VVGARRSsWRVISsI 14-3-3 X X 52631 +LATS2 LATS2 Q9NRM7 human KIF23 9493 Q02241 KIF23 human S814 470674 LRHRRsRsAGDRWVD MKLP1_Arf_bdg X +LATS2 LATS2 Q9NRM7 human AMOT 154796 Q4VCS5 AMOT human S175 28699604 QGHVRSLsERLMQMS X X +LATS2 LATS2 Q9NRM7 human KIF23 9493 Q02241 KIF23 human S716 453934 QLHRRsNsCsSISVA X +LATS2 LATS2 Q9NRM7 human PRPS2 5634 P11908 PRPS2 human T285 1874748502 EDkMkHCtKIQVIDI Pribosyl_synth X X +LATS2 LATS2 Q9NRM7 human YAP1 iso2 10413 P46937-2 YAP1 human S164 471933 AQHLRQssFEIPDDV X +MLKL MLKL Q8NB16 human CNR2 1269 P34972 CNR2 human S352 450818 kITPWPDsRDLDLSD X +CAMKK2 CAMKK2 Q96RR4 human SIRT1 23411 Q96EB6 SIRT1 human S47 452899 DGPGLERsPGEPGGA X X 2314 +CAMKK2 CAMKK2 Q96RR4 human AMPKA1 65248 P54645 Prkaa1 rat T183 448786 SDGEFLRtsCGSPNY Pkinase X 2535; 2531; 4188; 5256; 50081; 74281 +CAMKK2 CAMKK2 Q96RR4 human AMPKA1 5562 Q13131 PRKAA1 human T183 448786 sDGEFLRtsCGsPNy Pkinase X X 2535; 2531; 4188; 5256; 50081; 74281 +CAMKK2 CAMKK2 Q96RR4 human AMPKA2 108079 Q8BRK8 Prkaa2 mouse T172 448026 sDGEFLRtsCGsPNY Pkinase X X 2535; 2531; 5256; 50081; 74281 +CAMKK2 CAMKK2 Q96RR4 human SIRT1 23411 Q96EB6 SIRT1 human S27 452898 ADREAAssPAGEPLR X X 2327 +CAMKK2 CAMKK2 Q96RR4 human CAMKK2 83506 O88831 Camkk2 rat T482 21336500 KHIPSLAtVILVKTM X +CAMKK2 CAMKK2 Q96RR4 human PACSIN1 29704 Q9Z0W5 Pacsin1 rat T355 20503414 DRGQAYAtEWsDDEs X +CAMKK2 CAMKK2 Q96RR4 human CAMKK2 10645 Q96RR4 CAMKK2 human T85 31873289 GQEVPLDtSGSQARP X X +CAMKK2 CAMKK2 Q96RR4 human AMPKA2 5563 P54646 PRKAA2 human T172 448026 sDGEFLRtsCGsPNy Pkinase X X 2535; 2531; 5256; 50081; 74281 +CAMKK2 CAMKK2 Q96RR4 human Akt1 207 P31749 AKT1 human T308 447856 kDGAtMKtFCGtPEy Pkinase X 5106; 2965; 9275; 4056; 5056; 13842; 13038; 43506; 48646; 86758; 80722; 77440; 80556 +Pak6 PAK6 Q3ULB5 mouse LIMK1 3984 P53667 LIMK1 human T508 447808 PDRKKRYtVVGNPYW PK_Tyr_Ser-Thr X 3841 +MAP4K4 HGK O95819 human Radixin 5962 P35241 RDX human T564 448374 AGRDKyKtLRQIRQG ERM_C X 3141; 3726; 32600 +MAP4K4 HGK O95819 human Ezrin 7430 P15311 EZR human T567 448104 QGRDkyKtLRQIRQG ERM_C X 3141; 3726; 32600 +MAP4K4 HGK O95819 human SMAD1 4086 Q15797 SMAD1 human T322 25802105 sNVNRNStIENTRRH MH2 X X +MAP4K4 HGK O95819 human GR 2908 P04150 NR3C1 human T562 1872513501 StWRIMTtLNMLGGR Hormone_recep X +MAP4K4 HGK O95819 human LATS1 9113 O95835 LATS1 human T1079 457595 EHAFyEFtFRRFFDD X X 8654 +MAP4K4 HGK O95819 human Huntingtin 3064 P42858 HTT human S13 10206805 kLMkAFEsLksFQQQ X X +MAP4K4 HGK O95819 human MLK3 4296 Q16584 MAP3K11 human T738 4271419 EEEPRGGtVsPPPGT X X +MAP4K4 HGK O95819 human ADAM10 102 O14672 ADAM10 human S436 4697183 NNKFSLCsIRNISQV Reprolysin_2 X X +MAP4K4 HGK O95819 human GR 2908 P04150 NR3C1 human T519 1872513502 SENPGNKtIVPAtLP X +MAP4K4 HGK O95819 human Moesin 4478 P26038 MSN human T558 447706 LGRDKyKtLRQIRQG ERM_C X X 3141; 3726; 32600 +MAP4K4 HGK O95819 human Huntingtin 3064 P42858 HTT human T3 10206804 _____MAtLEkLMkA X X +Pak3 PAK3 Q61036 mouse Cortactin 13043 Q60598 Cttn mouse S113 465664 skLSKHCsQVDsVrG HS1_rep X +Pak3 PAK3 Q61036 mouse Cortactin 13043 Q60598 Cttn mouse S282 465666 VQSERQDsSAVGFDy HS1_rep X +Pak3 PAK3 Q61036 mouse Caldesmon 373965 P12957 CALD1 chicken S702 456707 GLKVGVSsRINEWLT Caldesmon X +Pak3 PAK3 Q61036 mouse Cortactin 13043 Q60598 Cttn mouse S150 465665 GKTEKHAsQkDysSG HS1_rep X +Pak3 PAK3 Q61036 mouse Caldesmon 373965 P12957 CALD1 chicken S672 456706 EGVRNIKsMWEKGNV Caldesmon X +Mapkapk3 MAPKAPK3 Q3UMW7 mouse WNK4 65266 Q96J92 WNK4 human S575 53332700 PFLFRHAsYSSTTSD X +Mapkapk3 MAPKAPK3 Q3UMW7 mouse TTP 22695 P22893 Zfp36 mouse S52 451150 RLTGRSTsLVEGRsC X +Mapkapk3 MAPKAPK3 Q3UMW7 mouse TTP 22695 P22893 Zfp36 mouse S178 451151 HVLRQsIsFsGLPsG X +Camk2a CAMK2A P11275 rat CAMK2A 25400 P11275 Camk2a rat T286 447797 sCMHRQEtVDCLkkF X X 12716 +Camk2a CAMK2A P11275 rat Tau iso8 4137 P10636-8 MAPT human T231 449079 KKVAVVRtPPKsPss X 20473; 71429 +Camk2a CAMK2A P11275 rat SAPAP1 65040 P97836 Dlgap1 rat S389 481511 YLKATQPsLTELTTL X +Camk2a CAMK2A P11275 rat EGFR 1956 P00533 EGFR human S768 452119 DEAyVMAsVDNPHVC PK_Tyr_Ser-Thr X +Camk2a CAMK2A P11275 rat Tau iso2 4137 P10636-2 MAPT human S315 449082 PVVSGDTsPRHLsNV X 35834; 20194; 98523; 91600; 49562 +Camk2a CAMK2A P11275 rat EGFR 1956 P00533 EGFR human S1070 448051 DsFLQRyssDPtGAL X 2238 +Camk2a CAMK2A P11275 rat RYR2 689560 B0LPN4 Ryr2 rat S2804 458801 IsQTsQVsIDAAHGY X X +Camk2a CAMK2A P11275 rat DRP1 74006 Q8K1M6 Dnm1l mouse S622 454690 PIPIMPAsPQKGHAV X 3455; 4494; 63940 +Camk2a CAMK2A P11275 rat CAMK2B 24245 P08413 Camk2b rat T287 450048 sMMHRQEtVECLkkF X 12716 +Camk2a CAMK2A P11275 rat SYN1 281510 P17599 SYN1 cow S568 456356 PQATRQTsVSGQAPP X +Camk2a CAMK2A P11275 rat nNOS 24598 P29476 Nos1 rat S847 447886 SYKVRFNsVSSYSDS Flavodoxin_1 X X +Camk2a CAMK2A P11275 rat 14-3-3 beta 56011 P35213 Ywhab rat S65 467269 RSsWRVIsSIEQkTE 14-3-3 X +Camk2a CAMK2A P11275 rat EGFR 1956 P00533 EGFR human S1166 452120 QkGsHQIsLDNPDyQ X +Camk2a CAMK2A P11275 rat Tau iso6 4137 P10636-6 MAPT human S346 449082 PVVSGDTsPRHLSNV X 35834; 20194; 98523; 91600; 49562 +Camk2a CAMK2A P11275 rat Spinophilin 84686 O35274 Ppp1r9b rat S100 448729 LsLPRAssLNENVDH X X +Camk2a CAMK2A P11275 rat SAPAP1 65040 P97836 Dlgap1 rat S691 12130200 KTSSKFQsVGVQVEE GKAP X +Camk2a CAMK2A P11275 rat TH iso4 7054 P07101-4 TH human S44 448545 RFIGRRQsLIEDARK TOH_N X 2791 +Camk2a CAMK2A P11275 rat DLG1 25252 Q62696 Dlg1 rat S39 451614 SSIERVIsIFQSNLF L27_1 X +Camk2a CAMK2A P11275 rat SynGAP 192117 Q9QUH6 Syngap1 rat S1118 481550 kEGsIGGsGGsGGGG DUF3498 X +Camk2a CAMK2A P11275 rat CAMK2B 24245 P08413 Camk2b rat T254 2048065 NLINQMLtINPAkRI Pkinase X +Camk2a CAMK2A P11275 rat PLA2G4A 5321 P47712 PLA2G4A human S515 447598 SDFATQDsFDDDELD PLA2_B X X +Camk2a CAMK2A P11275 rat Tau iso6 4137 P10636-6 MAPT human T173 449079 KKVAVVRtPPKsPSS X 20473; 71429 +Camk2a CAMK2A P11275 rat Tau iso8 4137 P10636-8 MAPT human S396 449081 GAEIVyKsPVVsGDt X 9632 +Camk2a CAMK2A P11275 rat CPEB 293056 P0C279 Cpeb1 rat T171 449610 VRGSRLDtRPILDSR CEBP1_N X X +Camk2a CAMK2A P11275 rat SynGAP 192117 Q9QUH6 Syngap1 rat S1138 451016 PSITkQHsQTPSTLN DUF3498 X +Camk2a CAMK2A P11275 rat Tau iso8 4137 P10636-8 MAPT human S404 449082 PVVsGDtsPRHLsNV X 35834; 20194; 98523; 91600; 49562 +Camk2a CAMK2A P11275 rat kalirin 84009 P97924 Kalrn rat T77 1315601 DVCKRGFtVIIDMRG CRAL_TRIO_2 X X +Camk2a CAMK2A P11275 rat Vimentin 22352 P20152 Vim mouse S83 451816 GVRLLQDsVdFsLAD Filament_head X 3878; 12569 +Camk2a CAMK2A P11275 rat Tau iso8 4137 P10636-8 MAPT human S262 447930 NVKskIGstENLkHQ Tubulin-binding X X +Camk2a CAMK2A P11275 rat TH iso3 7054 P07101-3 TH human S19 448542 KGFRRAVsELDAKQA TOH_N X +Camk2a CAMK2A P11275 rat CAMK4 25050 P13234 Camk4 rat S333 2827403 VkAVVAssRLGsASS X +Camk2a CAMK2A P11275 rat NUMB 8650 P49757 NUMB human S276 456490 EQLARQGsFrGFPAL NumbF X 4140; 9878 +Camk2a CAMK2A P11275 rat Tau iso5 4137 P10636-5 MAPT human T231 449079 KKVAVVRtPPKsPSS X 20473; 71429 +Camk2a CAMK2A P11275 rat CACNB2 116600 Q8VGC3 Cacnb2 rat T549 470081 RGLSRQEtFDsETQE X X +Camk2a CAMK2A P11275 rat PSD-95 29495 P31016 Dlg4 rat S73 471390 ITLERGNsGLGFSIA PDZ X +Camk2a CAMK2A P11275 rat TPH2 121278 Q8IWU9 TPH2 human S19 470085 YWARRGFsLDSAVPE X +Camk2a CAMK2A P11275 rat GABRG2 14406 P22723 Gabrg2 mouse S393 452034 TIDIRPRsAtIQMNN Neur_chan_memb X +Camk2a CAMK2A P11275 rat TH iso4 7054 P07101-4 TH human S19 448542 KGFRRAVsELDAKQA TOH_N X +Camk2a CAMK2A P11275 rat GABRG2 14406 P22723 Gabrg2 mouse S381 452033 NPLLRMFsFKAPTID Neur_chan_memb X +Camk2a CAMK2A P11275 rat GluR1 50592 P19490 Gria1 rat S849 448565 FCLIPQQsINEAIrT X X 75574 +Camk2a CAMK2A P11275 rat SynGAP 192117 Q9QUH6 Syngap1 rat S1121 481551 sIGGsGGsGGGGGGG DUF3498 X +Camk2a CAMK2A P11275 rat CREB iso1 81646 P15337-1 Creb1 rat S133 448228 EILsRRPsYRkILND pKID X 9187; 9196; 9198; 4095; 14228; 14001; 39561; 80120; 44864; 54960; 95995 +Camk2a CAMK2A P11275 rat APOBEC3G 60489 Q9HC16 APOBEC3G human T218 21656100 WVRGRHEtyLCYEVE NAD2 X +Camk2a CAMK2A P11275 rat NMDAR2B 24410 Q00960 Grin2b rat S1303 450171 NKLRRQHsyDtFVDL NMDAR2_C X X 20274; 71335 +Camk2a CAMK2A P11275 rat Tau iso5 4137 P10636-5 MAPT human S365 449081 GAEIVYKsPVVsGDT X 9632 +Camk2a CAMK2A P11275 rat SAPAP3 286923 P97838 Dlgap3 rat S930 481288 GVPVKERsLDsVDRQ GKAP X +Camk2a CAMK2A P11275 rat HER2 2064 P04626 ERBB2 human T1172 451643 AtLERPKtLsPGKNG X X +Camk2a CAMK2A P11275 rat MOR-1 25601 P33535 Oprm1 rat S261 447781 LMILRLKsVRMLsGS 7tm_1 X +Camk2a CAMK2A P11275 rat SHANK3 59312 Q9JLU4 Shank3 rat S1511 2048965 QLNKDTRsLGEEPVG X +Camk2a CAMK2A P11275 rat SynGAP 192117 Q9QUH6 Syngap1 rat S766 4792737 MMRDLNssIDLQSFM DUF3498 X +Camk2a CAMK2A P11275 rat mGluR1 24414 P23385 Grm1 rat T871 4713375 KLPCRSNtFLNIFRR X +Camk2a CAMK2A P11275 rat TH 7054 P07101 TH human S19 448542 KGFRRAVsELDAKQA TOH_N X +Camk2a CAMK2A P11275 rat SHANK3 59312 Q9JLU4 Shank3 rat S781 471376 KGIPRTKsVGEDEKL X X +Camk2a CAMK2A P11275 rat C/EBP-beta 1051 P17676 CEBPB human S325 11180067 EQLSRELsTLRNLFk X +Camk2a CAMK2A P11275 rat GABRB1 14400 P50571 Gabrb1 mouse S434 450244 GRIRRRAsQLKVKIP Neur_chan_memb X +Camk2a CAMK2A P11275 rat CAMK2A 25400 P11275 Camk2a rat S314 451708 MLAtRNFsGGKSGGN X +Camk2a CAMK2A P11275 rat SYN1 24949 P09951 Syn1 rat S603 450236 AGPIRQAsQAGPGPR X 88246 +Camk2a CAMK2A P11275 rat CREB iso1 81646 P15337-1 Creb1 rat S142 448547 RkILNDLssDAPGVP pKID X X +Camk2a CAMK2A P11275 rat SynGAP 192117 Q9QUH6 Syngap1 rat S780 451015 MARGLNSsMDMARLP DUF3498 X +Camk2a CAMK2A P11275 rat CAMK2A 25400 P11275 Camk2a rat T253 451571 DLINkMLtINPskRI Pkinase X +Camk2a CAMK2A P11275 rat Tau iso2 4137 P10636-2 MAPT human S307 449081 GAEIVYKsPVVSGDT X 9632 +Camk2a CAMK2A P11275 rat CAMK2B 24245 P08413 Camk2b rat S315 451707 MLAtRNFsVGRQttA X +Camk2a CAMK2A P11275 rat TH 25085 P04177 Th rat S19 448542 KGFRRAVsEQDAKQA TOH_N X +Camk2a CAMK2A P11275 rat Abi-1 11308 Q8CBW3 Abi1 mouse S88 27115701 SQLRRMEsSINHISQ X +Camk2a CAMK2A P11275 rat VAMP2 22318 P63044 Vamp2 mouse S61 451445 LERDQkLsELDDRAD Synaptobrevin X +Camk2a CAMK2A P11275 rat ASIC1 79123 P55926 Asic1 rat S477 449558 QKEAKRssADKGVAL X +Camk2a CAMK2A P11275 rat Kv4.3 65195 Q62897 Kcnd3 rat S569 455338 LPATRLRsMQELSTI X +Camk2a CAMK2A P11275 rat CAMK2A 25400 P11275 Camk2a rat T305 448802 kLkGAILttMLAtRN X +Camk2a CAMK2A P11275 rat CAMK2A 25400 P11275 Camk2a rat T306 449596 LkGAILttMLAtRNF X +Camk2a CAMK2A P11275 rat EGFR 1956 P00533 EGFR human S1071 448052 sFLQRyssDPtGALt X 2238 +Camk2a CAMK2A P11275 rat CAMK4 25050 P13234 Camk4 rat S341 2827400 RLGsASSsHTNIQES X +Camk2a CAMK2A P11275 rat DLG1 25252 Q62696 Dlg1 rat S232 451615 ITLERGNsGLGFSIA PDZ X X +Camk2a CAMK2A P11275 rat GluR KA2 24407 Q63273 Grik5 rat S859 27535800 AVSCRKTsRSRRRRR X +Camk2a CAMK2A P11275 rat CACNA1C 24239 P22002 Cacna1c rat T1603 7437803 RTALRIKtEGNLEQA Ca_chan_IQ X X +Camk2a CAMK2A P11275 rat SHANK3 59312 Q9JLU4 Shank3 rat S685 3844913 PPPKRAPsTTLTLRS X +Camk2a CAMK2A P11275 rat EGFR 1956 P00533 EGFR human S1081 452121 tGALtEDsIDDtFLP X +Camk2a CAMK2A P11275 rat Vimentin 22352 P20152 Vim mouse S39 451766 TTsTRTysLGsALRP Filament_head X 13614 +Camk2a CAMK2A P11275 rat RYR2 689560 B0LPN4 Ryr2 rat S2798 448848 yNRTRRIsQTsQVsI X +Camk2a CAMK2A P11275 rat LRRC7 117284 P70587 Lrrc7 rat T827 12157800 PLELEQstHRHtPET X +Camk2a CAMK2A P11275 rat GABRG2 14406 P22723 Gabrg2 mouse T395 452035 DIRPRsAtIQMNNAT Neur_chan_memb X +Camk2a CAMK2A P11275 rat CAMK4 25050 P13234 Camk4 rat S332 450138 AVkAVVAssRLGsAS X +Camk2a CAMK2A P11275 rat Tau iso5 4137 P10636-5 MAPT human S373 449082 PVVsGDTsPRHLSNV X 35834; 20194; 98523; 91600; 49562 +Camk2a CAMK2A P11275 rat TH 25085 P04177 Th rat S40 448545 RFIGRRQsLIEDARK TOH_N X 2791 +Camk2a CAMK2A P11275 rat TH iso2 7054 P07101-2 TH human S19 448542 KGFRRAVsELDAKQA TOH_N X +Camk2a CAMK2A P11275 rat SYN1 24949 P09951 Syn1 rat S566 456356 PQAtRQAsIsGPAPP X +Camk2a CAMK2A P11275 rat TH iso2 7054 P07101-2 TH human S67 448545 RFIGRRQsLIEDARK TOH_N X 2791 +Camk2a CAMK2A P11275 rat SHANK3 59312 Q9JLU4 Shank3 rat S694 2022961 TLTLRSKsMTAELEE X +Camk2a CAMK2A P11275 rat GluR KA2 24407 Q63273 Grik5 rat T976 27535801 PTGPRELtEHE____ X +Camk2a CAMK2A P11275 rat 14-3-3 beta 56011 P35213 Ywhab rat S60 450226 VVGARRSsWRVIsSI 14-3-3 X 52631 +Camk2a CAMK2A P11275 rat Tau iso6 4137 P10636-6 MAPT human S338 449081 GAEIVYKsPVVSGDT X 9632 +Camk2a CAMK2A P11275 rat Spinophilin 84686 O35274 Ppp1r9b rat S99 2023901 RLsLPRAssLNENVD X +Camk2a CAMK2A P11275 rat MOR-1 25601 P33535 Oprm1 rat S266 447782 LKsVRMLsGSKEKDR 7tm_1 X +Camk2a CAMK2A P11275 rat GluR KA2 24407 Q63273 Grik5 rat S892 19014315 LsNGKLysAGAGGDA X +Camk2a CAMK2A P11275 rat Tau iso6 4137 P10636-6 MAPT human S177 449080 VVRtPPKsPSSAKSR X 20473 +Camk2a CAMK2A P11275 rat TH 7054 P07101 TH human S71 448545 RFIGRRQsLIEDARK TOH_N X 2791 +Camk2a CAMK2A P11275 rat SynGAP 192117 Q9QUH6 Syngap1 rat S1073 469613 PPLQRGKsQQLTVsA DUF3498 X +Camk2a CAMK2A P11275 rat GABRB1 14400 P50571 Gabrb1 mouse S409 451812 IQyRKPLssREGFGR Neur_chan_memb X +Camk2a CAMK2A P11275 rat SynGAP 192117 Q9QUH6 Syngap1 rat S765 4792731 yMMRDLNssIDLQSF DUF3498 X +Camk2a CAMK2A P11275 rat SAPAP2 116681 P97837 Dlgap2 rat S1012 2049577 FPITREKsLDLPDRQ GKAP X +Camk2a CAMK2A P11275 rat GABRB3 14402 P63080 Gabrb3 mouse S406 486453 GIQYRKQsMPKEGHG Neur_chan_memb X +Camk2a CAMK2A P11275 rat SYN1 281510 P17599 SYN1 cow S605 450236 AGPTRQAsQAGPMPR X +Camk2a CAMK2A P11275 rat KCNMA1 282573 Q28204 KCNMA1 cow T139 469977 PVDEKEEtVAAEVGW X +Camk2a CAMK2A P11275 rat LRRC7 117284 P70587 Lrrc7 rat S826 2049457 VPLELEQstHRHtPE X +Camk2a CAMK2A P11275 rat APP 54226 P08592 App rat T729 448201 MLKKKQYtsIHHGVV APP_amyloid X +Camk2a CAMK2A P11275 rat CAMK2A 25400 P11275 Camk2a rat S279 452116 SHRSTVAsCMHRQEt X +Camk2a CAMK2A P11275 rat SYN1 20964 O88935 Syn1 mouse S605 450236 AGPtRQAsQAGPGPr X 88246 +Camk2a CAMK2A P11275 rat STMN1 29332 P13668 Stmn1 rat S16 448554 kELEKRAsGQAFELI Stathmin X 3353 +Camk2a CAMK2A P11275 rat NEUROD1 29458 Q64289 Neurod1 rat S336 451110 IPIDNIMsFDSHSHH X X +Camk2a CAMK2A P11275 rat Tau iso5 4137 P10636-5 MAPT human S235 449080 VVRtPPKsPSSAKSR X 20473 +Camk2a CAMK2A P11275 rat SAPAP1 65040 P97836 Dlgap1 rat S947 481515 APLIRERsLESSQRQ GKAP X +Camk2a CAMK2A P11275 rat ASIC1 79123 P55926 Asic1 rat S476 458230 CQKEAKRssADKGVA X +Camk2a CAMK2A P11275 rat CAMK4 25050 P13234 Camk4 rat S337 2192720 VAssRLGsASSsHTN X +Camk2a CAMK2A P11275 rat myogenin 17928 P12979 Myog mouse T87 451161 VDRRRAAtLREKRRL HLH X +Camk2a CAMK2A P11275 rat PEX5L 286937 Q925N3 Pex5l rat S237 481412 ALLsRNHsLEEEFER X +Camk2a CAMK2A P11275 rat Tau iso8 4137 P10636-8 MAPT human S235 449080 VVRtPPKsPssAKsR X 20473 +Camk2a CAMK2A P11275 rat NUMBL 292732 A1L1I3 Numbl rat S305 456489 EQLVRQGsFRGFPAL NumbF X +Camk2a CAMK2A P11275 rat TH iso3 7054 P07101-3 TH human S40 448545 RFIGRRQsLIEDARK TOH_N X 2791 +Camk2a CAMK2A P11275 rat SHANK1 78957 Q9WV48 Shank1 rat S783 12130201 RLPPPAIsLRSKSMT X +Camk2a CAMK2A P11275 rat SynGAP 192117 Q9QUH6 Syngap1 rat S1114 481549 QsLSkEGsIGGsGGs DUF3498 X +Camk2a CAMK2A P11275 rat RPT6 81827 P62198 Psmc5 rat S120 483970 RVALRNDsYTLHKIL Prot_ATP_ID_OB X +Camk2a CAMK2A P11275 rat SYT1 25716 P21707 Syt1 rat T112 448549 DVKDLGKtMKDQALK X X +CSNK2B CK2B P67870 human ATF-4 468 P18848 ATF4 human S215 27833501 IKEEDTPsDNDsGIC X +CSNK2B CK2B P67870 human TPM1 22003 P58771 Tpm1 mouse S283 451804 HALNDMtsI______ Tropomyosin X +CSNK2B CK2B P67870 human MYH9 4627 P35579 MYH9 human S1916 451181 AMNREVssLkNkLRr Myosin_tail_1 X +CSNK2B CK2B P67870 human NHE3 100009430 P26432 NHE-3 rabbit S719 3496800 KERELELsDPEEAPD X +CSNK2B CK2B P67870 human DLG3 iso2 1741 Q92796-2 DLG3 human S295 4710993 QGVTSNtsDSESSSK X +CSNK2B CK2B P67870 human SEC63 11231 Q9UGP8 SEC63 human S748 3215004 DsEGFEDsFEEEEEE X X +CSNK2B CK2B P67870 human RAD17 5884 O75943 RAD17 human S678 1184590201 IIIEDyEsDGt____ X +CSNK2B CK2B P67870 human p53 7157 P04637 TP53 human S392 447535 FktEGPDsD______ X X 9281 +CSNK2B CK2B P67870 human Snail1 6615 O95863 SNAI1 human S92 452602 VAELTsLsDEDsGkG X X +CSNK2B CK2B P67870 human SORT1 6272 Q99523 SORT1 human S825 468808 KsGyHDDsDEDLLE_ X +CSNK2B CK2B P67870 human OLIG2 50913 Q9EQW6 Olig2 mouse S13 18357900 SLVSsRPssPEPDDL X +CSNK2B CK2B P67870 human CCDC106 29903 Q9BWC9 CCDC106 human S147 1867984200 SGASEEGsASERRRQ CCDC106 X X +CSNK2B CK2B P67870 human CCDC106 29903 Q9BWC9 CCDC106 human S130 31084482 GGAGGEAsDPESAAS CCDC106 X X +CSNK2B CK2B P67870 human FADD 8772 Q13158 FADD human S200 40510683 MsPMsWNsDAsTSEA X X +CSNK2B CK2B P67870 human SEC63 11231 Q9UGP8 SEC63 human S574 27440601 EEVsDKGsDsEEEET X X +CSNK2B CK2B P67870 human SEC63 11231 Q9UGP8 SEC63 human S576 27440600 VsDKGsDsEEEETNR X X +CSNK2B CK2B P67870 human DLG3 58948 Q62936 Dlg3 rat S632 4710993 KGVTSNTsDSESSSK X +Mapk9 JNK2 P49186 rat Doublecortin iso2 1641 O43602-2 DCX human T321 451361 TSSSQLStPKSKQsP X +Mapk9 JNK2 P49186 rat Doublecortin iso2 1641 O43602-2 DCX human S334 451359 sPIStPTsPGSLRkH X 3453; 14053 +Mapk9 JNK2 P49186 rat Doublecortin iso2 1641 O43602-2 DCX human T331 469976 SKQsPIStPTsPGSL X +Mapk9 JNK2 P49186 rat CTNND2 114028 NP_001258431 Ctnnd2 rat S444 480954 RTSTAPSsPGVDSVP X +FGFR1 FGFR1 P11362 human IDH1 3417 O75874 IDH1 human Y42 3563660 VELDLHsyDLGIENR Iso_dh X +FGFR1 FGFR1 P11362 human PKM 18746 P52480 Pkm mouse Y105 450528 FAsDPILyRPVAVAL PK X X 3827 +FGFR1 FGFR1 P11362 human PDP1 54704 Q9P0J1 PDP1 human Y94 15422109 SILkANEySFkVPEF X X +FGFR1 FGFR1 P11362 human FGFR1 2260 P11362 FGFR1 human Y653 447918 RDIHHIDyykKTTNG PK_Tyr_Ser-Thr X 3471; 3476; 52928 +FGFR1 FGFR1 P11362 human FGFR1 2260 P11362 FGFR1 human Y583 448702 RRPPGLEyCyNPsHN PK_Tyr_Ser-Thr X +FGFR1 FGFR1 P11362 human AMOTL2 51421 Q9Y2J4 AMOTL2 human Y107 15561222 kGEELPTyEEAKAHS X +FGFR1 FGFR1 P11362 human ZNF198 7750 Q9UBW7 ZMYM2 human Y680 464588 KLHCIVTyCEyCQEE X +FGFR1 FGFR1 P11362 human ZNF198 7750 Q9UBW7 ZMYM2 human Y683 464589 CIVTyCEyCQEEKTL X +FGFR1 FGFR1 P11362 human FGFR1 2260 P11362 FGFR1 human Y585 448703 PPGLEyCyNPsHNPE PK_Tyr_Ser-Thr X +FGFR1 FGFR1 P11362 human ZNF198 7750 Q9UBW7 ZMYM2 human Y557 464584 QCIGPNGyMEPYCSt zf-FCS X +FGFR1 FGFR1 P11362 human NUDE1 67203 Q9CZA6 Nde1 mouse Y279 448969 ASCRNFMyDQsPsRT NUDE_C X +FGFR1 FGFR1 P11362 human PDHK1 5163 Q15118 PDK1 human Y136 11057941 AEDAkAIyDFTDTVI BCDHK_Adom3 X X +FGFR1 FGFR1 P11362 human ZNF198 7750 Q9UBW7 ZMYM2 human Y502 464583 CQSCVSEykQVGSHP zf-FCS X +FGFR1 FGFR1 P11362 human STAT3 6774 P40763 STAT3 human Y705 448192 DPGsAAPyLktKFIC X 4093; 9145; 4324; 9131; 9138; 4323; 4074; 4113; 48313; 20977; 25023; 8119; 52075; 52527; 73533; 61958; 73452; 16185; 74309 +FGFR1 FGFR1 P11362 human NUDE1 67203 Q9CZA6 Nde1 mouse Y90 912008302 EMQHSEGyRQISALE X +FGFR1 FGFR1 P11362 human LDH-A 3939 P00338 LDHA human Y83 3780568 kIVSGkDyNVTANsk Ldh_1_N X +FGFR1 FGFR1 P11362 human PDHK1 5163 Q15118 PDK1 human Y244 465268 RRLCDLyyINSPELE X X +FGFR1 FGFR1 P11362 human FGFR1 2260 P11362 FGFR1 human Y730 448642 SNCTNELyMMMRDCW PK_Tyr_Ser-Thr X +FGFR1 FGFR1 P11362 human ZDHHC3 69035 Q8R173 Zdhhc3 mouse Y18 462842 DIERKPEyLQPEKCA X +FGFR1 FGFR1 P11362 human ZNF198 7750 Q9UBW7 ZMYM2 human Y729 464590 LRCVTCNyCSQLCKk zf-FCS X +FGFR1 FGFR1 P11362 human FGFR1 2260 P11362 FGFR1 human Y654 447919 DIHHIDyykKTTNGR PK_Tyr_Ser-Thr X 3471; 3476; 52928 +FGFR1 FGFR1 P11362 human ITGB4 3691 P16144 ITGB4 human Y1564 456323 LQGYSVEyQLLNGGE fn3 X +FGFR1 FGFR1 P11362 human NLGN1 192167 Q99K10 Nlgn1 mouse Y782 1008111 RTACPPDyTLAMRRS X +FGFR1 FGFR1 P11362 human ZNF198 7750 Q9UBW7 ZMYM2 human Y595 464585 KRNsLPQyQATMPDG X +FGFR1 FGFR1 P11362 human FGFR1 2260 P11362 FGFR1 human Y154 448774 NRMPVAPyWTSPEKM X +FGFR1 FGFR1 P11362 human FGFR1 2260 P11362 FGFR1 human Y766 447922 ALTSNQEyLDLSMPL X 2544; 84309 +FGFR1 FGFR1 P11362 human FGFR1 2260 P11362 FGFR1 human Y463 448641 MLAGVSEyELPEDPR X +FGFR1 FGFR1 P11362 human PDP1 54704 Q9P0J1 PDP1 human Y381 15422118 DQLNDNEyTkFIPPN PP2C X +FGFR1 FGFR1 P11362 human PLCG1 5335 P19174 PLCG1 human Y783 447667 EGRNPGFyVEANPMP X 2821; 14461; 14008; 25678; 88717 +FGFR1 FGFR1 P11362 human LDH-A 3939 P00338 LDHA human Y10 454712 tLkDQLIyNLLkEEQ X X +FGFR1 FGFR1 P11362 human PDHA1 5160 P08559 PDHA1 human Y301 454753 MsDPGVsyRtREEIQ E1_dh X +FGFR1 FGFR1 P11362 human PDHK1 5163 Q15118 PDK1 human Y243 462384 ARRLCDLyyINSPEL X X +FGFR1 FGFR1 P11362 human ACAT1 38 P24752 ACAT1 human Y407 10943316 HALKQGEyGLASICN Thiolase_C X +FGFR1 FGFR1 P11362 human ZNF198 7750 Q9UBW7 ZMYM2 human Y605 464586 TMPDGkLyNFCNsSC X +ERN1 IRE1 O75460 human IRE1 2081 O75460 ERN1 human Y628 41192601 EHPNVIRyFCTEkDR Pkinase X +GRK3 GRK3 P35626 human KOR-3 4987 P41146 OPRL1 human S346 1868135700 LRRDVQVsDRVRsIA X +GRK3 GRK3 P35626 human KOR-1 18387 P33534 Oprk1 mouse S369 449609 NtVQDPAsMRDVGGM X X +GRK3 GRK3 P35626 human CCR5 1234 P51681 CCR5 human S337 448725 EAPERAssVyTRstG X +GRK3 GRK3 P35626 human SSTR2 P30680 Sstr2 rat T353 7652102 DKsRLNEttEtQRtL X +GRK3 GRK3 P35626 human SSTR2 6752 P30874 SSTR2 human S341 7652103 GTDDGERsDsKQDKS X +GRK3 GRK3 P35626 human MOR-1 18390 P42866 Oprm1 mouse T376 20727901 NtREHPstANtVDRT X +GRK3 GRK3 P35626 human KOR-3 4987 P41146 OPRL1 human S351 1868135701 QVsDRVRsIAKDVAL X +GRK3 GRK3 P35626 human DOR-1 4985 P41143 OPRD1 human T361 448551 RERVtACtPsDGPGG X +GRK3 GRK3 P35626 human CXCR4 12767 P70658 Cxcr4 mouse S354 12575201 VsTESEsssFHSs__ X +GRK3 GRK3 P35626 human SSTR2 P30680 Sstr2 rat T359 12577700 EttEtQRtLLNGDLQ X +GRK3 GRK3 P35626 human TXA2-R iso2 6915 P21731-2 TBXA2R human S357 469629 RLPGSSDsRASASRA X +GRK3 GRK3 P35626 human DOR-1 4985 P41143 OPRD1 human S363 448550 RVtACtPsDGPGGGA X +GRK3 GRK3 P35626 human ADRB2 154 P07550 ADRB2 human S355 458916 KAyGNGyssNGNtGE X X +GRK3 GRK3 P35626 human TXA2-R iso2 6915 P21731-2 TBXA2R human S239 469628 AQQRPRDsEVEMMAQ 7tm_1 X +GRK3 GRK3 P35626 human KOR-3 4987 P41146 OPRL1 human S363 27150200 VALACKtsETVPRPA X +GRK3 GRK3 P35626 human CCR5 1234 P51681 CCR5 human S342 449902 AssVyTRstGEQEIs X +GRK3 GRK3 P35626 human SSTR2 P30680 Sstr2 rat T356 12577701 RLNEttEtQRtLLNG X +GRK3 GRK3 P35626 human SSTR2 P30680 Sstr2 rat T354 7652101 KsRLNEttEtQRtLL X +GRK3 GRK3 P35626 human MOR-1 18390 P42866 Oprm1 mouse T370 447785 sARIRQNtREHPstA X +GRK3 GRK3 P35626 human MOR-1 18390 P42866 Oprm1 mouse S375 447784 QNtREHPstANtVDR X 3451 +GRK3 GRK3 P35626 human ADRB2 154 P07550 ADRB2 human S356 458917 AyGNGyssNGNtGEQ X X +GRK3 GRK3 P35626 human CCR5 1234 P51681 CCR5 human S336 449901 QEAPERAssVyTRst X +GRK3 GRK3 P35626 human SSTR2 6752 P30874 SSTR2 human S343 7652105 DDGERsDsKQDKSRL X +GRK3 GRK3 P35626 human CCR5 1234 P51681 CCR5 human S349 448724 stGEQEIsVGL____ X +GRK3 GRK3 P35626 human CXCR4 12767 P70658 Cxcr4 mouse S353 7997136 sVsTESEsssFHSs_ X +GRK3 GRK3 P35626 human KOR-3 4987 P41146 OPRL1 human T362 1868135702 DVALACKtsETVPRP X +GRK3 GRK3 P35626 human MOR-1 18390 P42866 Oprm1 mouse T379 20727900 EHPstANtVDRTNHQ X +SGK3 SGK3 Q96BR1 human ITCH 83737 Q96J02 ITCH human S450 470110 GWEkRTDsNGRVYFV WW X +SGK3 SGK3 Q96BR1 human L-plastin 3936 P13796 LCP1 human S5 450852 ___MARGsVsDEEMM X X +SGK3 SGK3 Q96BR1 human ITCH 83737 Q96J02 ITCH human T385 26342102 DHFTRTTtWQRPTLE WW X +SGK3 SGK3 Q96BR1 human WDR44 54521 Q5JSH3 WDR44 human S344 480095 PQRPRsNsGRELtDE X +SGK3 SGK3 Q96BR1 human FLI 2314 Q13045 FLII human S436 470489 RLRRRKDsAQDDQAK X X +SGK3 SGK3 Q96BR1 human FLI 2314 Q13045 FLII human T818 25787600 LHRPRHAtVSRsLEG Gelsolin X +SGK3 SGK3 Q96BR1 human GSK3B 2932 P49841 GSK3B human S9 449111 SGRPRttsFAEsCkP X X 9336; 9331; 9327; 9323; 9322; 9325; 5558; 8566; 79774; 8466; 25462; 14026; 14332; 14310; 14630 +SGK3 SGK3 Q96BR1 human MDM2 4193 Q00987 MDM2 human S166 448130 SsRRRAIsEtEENsD X 3521 +SGK3 SGK3 Q96BR1 human HSD17B4 3295 P51659 HSD17B4 human S318 7445507 NHtSRAtstATsGFA X +ATM ATM Q13315 human FANCI 55215 Q9NVI1 FANCI human S972 11952933 SLLNLLSsQEEDFNS FANCI_S3 X +ATM ATM Q13315 human KHDC3L 154288 Q587J8 KHDC3L human T145 1673970100 IEVREAGtQRSVEVR X +ATM ATM Q13315 human MCM3 17215 P25206 Mcm3 mouse S732 475062 sQEKtDDsQEtQDsQ X +ATM ATM Q13315 human NKX3-1 4824 Q99801 NKX3-1 human T166 28750702 kNLkLTEtQVKIWFQ Homeodomain X +ATM ATM Q13315 human 53BP1 7158 Q12888 TP53BP1 human S29 450162 IEDsQPEsQVLEDDS X 2674 +ATM ATM Q13315 human KHSRP 8570 Q92945 KHSRP human S670 482098 GPGAPPGsQPDySAA DUF1897 X X +ATM ATM Q13315 human Artemis 64421 Q96SD1 DCLRE1C human S503 466574 NDEITDEsLENFPSS X +ATM ATM Q13315 human RRM2B 50484 Q7LG56 RRM2B human S72 5014902 TAEEVDLsKDLPHWN Ribonuc_red_sm X X +ATM ATM Q13315 human DBN1 iso3 1627 Q16643-3 DBN1 human S647 472365 SEGYFSQsQEEEFAQ X X +ATM ATM Q13315 human KHDC3L 154288 Q587J8 KHDC3L human T156 25285513 VEVREAGtQRSVEVQ X +ATM ATM Q13315 human CROCC iso2 9696 Q5TZA2-2 CROCC human S922 481961 TESELRAsQEKISKM X X +ATM ATM Q13315 human FANCD2 2177 Q9BXW9 FANCD2 human S222 447816 LPEILGDsQHADVGK FancD2 X X +ATM ATM Q13315 human FBXW7 55294 Q969H0 FBXW7 human S26 482101 LRGNPSssQVDEEQM X +ATM ATM Q13315 human RAP80 51720 Q96RL1 UIMC1 human S205 486299 sGsWDQSsQPVFENV X +ATM ATM Q13315 human WAPL 23063 Q7Z5K2 WAPL human S498 1880758402 PPESNDNsQDSQSGT X +ATM ATM Q13315 human E2F1 1869 Q01094 E2F1 human S31 447867 ALRLLDSsQIVIISA X X +ATM ATM Q13315 human MDM2 4193 Q00987 MDM2 human S407 450263 SSSIIyssQEDVKEF X +ATM ATM Q13315 human p53 7157 P04637 TP53 human S37 447532 NVLsPLPsQAMDDLM TAD2 X 9289 +ATM ATM Q13315 human Chk2 11200 O96017 CHEK2 human S33 447549 tQsQGSSsQsQGIss X 2665 +ATM ATM Q13315 human SLX4 84464 Q8IY92 SLX4 human S1631 11952923 PHCQTLAsQTYKPSR X +ATM ATM Q13315 human NFAT5 10725 O94916 NFAT5 human S1247 452031 AMQSNSPsQEQQQQQ X +ATM ATM Q13315 human TRIM24 8805 O15164 TRIM24 human S217 1880463700 PEAVGVTsQRPVFCP X +ATM ATM Q13315 human POLL 27343 Q9UGP5 POLL human T204 62925702 EASDGEEtQVSAADL X +ATM ATM Q13315 human PTEN 5728 P60484 PTEN human T398 4695758 PFDEDQHtQItkV__ X +ATM ATM Q13315 human XPA 7507 P23025 XPA human S196 460698 RSLEVWGsQEALEEA X +ATM ATM Q13315 human hnRNP P2 2521 P35637 FUS human S42 3306333 QQSYSGYsQSTDTSG X +ATM ATM Q13315 human MDM2 4193 Q00987 MDM2 human S386 11956709 DDKITQAsQsQESED X X +ATM ATM Q13315 human USP2 9099 O75604 USP2 human S2 1880716202 ______MsQLSSTLK X +ATM ATM Q13315 human HUWE1 10075 Q7Z6Z7 HUWE1 human S3797 482007 QAAtsESsQSEAsVR X +ATM ATM Q13315 human SP1 6667 P08047 SP1 human S101 767911 DLTATQLsQGANGWQ X X +ATM ATM Q13315 human NRF1 4899 Q16656 NRF1 human T259 23255803 QKQRVSWtQALRTIV Nrf1_DNA-bind X +ATM ATM Q13315 human MED1 5469 Q15648 MED1 human S872 11952939 FNPDLLNsQsQSGFG X +ATM ATM Q13315 human RAGE 11596 Q62151 Ager mouse S376 4731271 EERKAPEsQEDEEER X X +ATM ATM Q13315 human HSP90A 3320 P07900 HSP90AA1 human T7 448320 _MPEEtQtQDQPMEE X 3488 +ATM ATM Q13315 human SMC3 9126 Q9UQE7 SMC3 human S1067 453059 GDVEGsQsQDEGEGs SMC_N X +ATM ATM Q13315 human OBFC2B 79035 Q9BQ15 NABP2 human T117 12526701 EPNPEYstQQAPNKA X +ATM ATM Q13315 human TET1 80312 Q8NFU7 TET1 human S1976 1881549504 PPsDEPLsDDPLSPA X X +ATM ATM Q13315 human YAP1 10413 P46937 YAP1 human Y391 15565111 PFLNsGtyHSRDEst X +ATM ATM Q13315 human MCPH1 79648 Q8NEM0 MCPH1 human S322 36125335 QKQAAGMsQETFEEk Microcephalin X +ATM ATM Q13315 human DTYMK 1841 P23919 DTYMK human S88 1253766700 PLIkEKLsQGVtLVV Thymidylate_kin X +ATM ATM Q13315 human RNF40 9810 O75150 RNF40 human S853 11952910 EkELTLRsQALELNK X +ATM ATM Q13315 human TOP2B iso2 7155 Q02880-2 TOP2B human S1134 34733062 SSDsGTPsGPDFNYI DNA_topoisoIV X +ATM ATM Q13315 human PPM1G 5496 O15355 PPM1G human S183 460849 GTGEEPGsQGLNGEA X X +ATM ATM Q13315 human AVEN 57099 Q9NQS1 AVEN human S308 4859800 NILPDQTsQDLKSKE X +ATM ATM Q13315 human MEN1 iso1 4221 O00255-1 MEN1 human S399 477697 EERPGEQsQGTQSQG Menin X +ATM ATM Q13315 human 53BP1 7158 Q12888 TP53BP1 human S1778 458312 FNkQYTEsQLRAGAG X 2675 +ATM ATM Q13315 human HUWE1 10075 Q7Z6Z7 HUWE1 human S3377 1249861 kACsPCSsQSSSSGI X +ATM ATM Q13315 human RFA2 6118 P15927 RPA2 human S29 448338 QsPGGFGsPAPsQAE X +ATM ATM Q13315 human DBF4 10926 Q9UBU7 DBF4 human S502 23010417 FSTDNSGsQPKQKsD X X +ATM ATM Q13315 human PPP1R2 5504 P41236 PPP1R2 human S44 2231000 DEELSKKsQKWDEMN X X +ATM ATM Q13315 human 4E-BP1 116636 Q62622 Eif4ebp1 rat S111 447526 KRAGGEEsQFEMDI_ eIF_4EBP X X +ATM ATM Q13315 human Artemis 64421 Q96SD1 DCLRE1C human S649 38410201 NADsQsssDFEVPst X +ATM ATM Q13315 human CBL 867 P22681 CBL human S866 1868914506 SEIENLMsQGYSYQD UBA X X +ATM ATM Q13315 human Chk2 11200 O96017 CHEK2 human S28 447548 PHGsVtQsQGSSsQs X +ATM ATM Q13315 human PRPF19 27339 Q9UMS4 PRPF19 human S149 25247501 VPQAVPSsQPSVVGA X +ATM ATM Q13315 human MAD1L1 8379 Q9Y6D9 MAD1L1 human S214 482335 kIQELQAsQEARADH MAD X X +ATM ATM Q13315 human UCHL3 7347 P15374 UCHL3 human S75 482705 EEEEKIKsQGQDVTS Peptidase_C12 X X +ATM ATM Q13315 human RANBP9 10048 Q96S59 RANBP9 human S550 54363507 NSINMSRsQQVNNFT CTLH X +ATM ATM Q13315 human SMC3 9126 Q9UQE7 SMC3 human S1083 453061 EsErGsGsQssVPSV SMC_N X X +ATM ATM Q13315 human ATM 472 Q13315 ATM human S367 467198 DTRSLEIsQSyTttQ X X +ATM ATM Q13315 human Pnk1 11284 Q96T60 PNKP human S114 460832 EEtRtPEsQPDtPPG X X 3522 +ATM ATM Q13315 human TAO1 57551 Q7L7X3 TAOK1 human T643 3627518 EELNKRQtQKDLEHA X +ATM ATM Q13315 human CtIP 5932 Q99708 RBBP8 human S664 448391 IDPGADLsQYKMDVT X +ATM ATM Q13315 human p53 7157 P04637 TP53 human S46 447536 AMDDLMLsPDDIEQW TAD2 X X 2521 +ATM ATM Q13315 human TOPBP1 11073 Q92547 TOPBP1 human S853 4742692 LEtPGRPsQQkRKPs X +ATM ATM Q13315 human NIPBL 25836 Q6KC79 NIPBL human S563 1880758400 sItQDSDsIKKPEEI X +ATM ATM Q13315 human TAO1 57551 Q7L7X3 TAOK1 human S990 3627517 SrSTsVTsQIsNGSH X +ATM ATM Q13315 human FANCI 55215 Q9NVI1 FANCI human S1121 482144 TLSEEAssQATLPNQ FANCI_S4 X +ATM ATM Q13315 human FANCD2 2177 Q9BXW9 FANCD2 human S717 453231 KDGGPVTsQESGQkL FancD2 X +ATM ATM Q13315 human AVEN 57099 Q9NQS1 AVEN human S135 4859801 VNNESGEsQRGTDFS X +ATM ATM Q13315 human HUWE1 10075 Q7Z6Z7 HUWE1 human S927 11952913 ISVNQWGsQLGLSVL X +ATM ATM Q13315 human MRE11A 4361 P49959 MRE11 human S678 460789 sskIMsQsQVsKGVD X X +ATM ATM Q13315 human TCF8 6935 P37275 ZEB1 human S585 36552500 GDGNLsPsQPPLKNL X X +ATM ATM Q13315 human MCM3 17215 P25206 Mcm3 mouse S725 475061 HtPKtDDsQEKtDDs X +ATM ATM Q13315 human FANCI 55215 Q9NVI1 FANCI human S730 482143 LDksADFsQsTSIGI FANCI_HD2 X +ATM ATM Q13315 human HUWE1 10075 Q7Z6Z7 HUWE1 human S2339 11952914 GQPEVLSsQEMQVEN X +ATM ATM Q13315 human ATM 472 Q13315 ATM human T1885 4731752 sQTSRsTtPANLDsE X +ATM ATM Q13315 human MED1 5469 Q15648 MED1 human S1141 11952942 sQGSSGSsQSKNSsQ X +ATM ATM Q13315 human FANCD2 2177 Q9BXW9 FANCD2 human T691 470035 yGLEEYDtQDGIAIN FancD2 X +ATM ATM Q13315 human L3MBTL2 83746 Q969R5 L3MBTL2 human S335 1046182902 RLEVVDKsQVsRTRM MBT X +ATM ATM Q13315 human APLF 200558 Q8IW19 APLF human S116 482841 MQCTLRNsQVLDEDN X +ATM ATM Q13315 human FBXL11 22992 Q9Y2K7 KDM2A human T632 482318 EVDQNEEtQDFEKKL PHD_4 X X +ATM ATM Q13315 human ID3 3399 Q02535 ID3 human S65 297110002 VPRGTQLsQVEILQR HLH X +ATM ATM Q13315 human ATM 472 Q13315 ATM human S2996 7433302 QECkRNLsDIDQSFN X X +ATM ATM Q13315 human BAT3 7917 P46379 BAG6 human S26 11952932 VLVktLDsQTRTFIV ubiquitin X +ATM ATM Q13315 human Smc1 8243 Q14683 SMC1A human S957 448697 IsQEEGssQGEDsVs SMC_N X X 4805; 58052 +ATM ATM Q13315 human Artemis 64421 Q96SD1 DCLRE1C human T656 38410200 sDFEVPstPEAELPK X +ATM ATM Q13315 human BRCA1 672 P38398 BRCA1 human S1524 448038 LQNRNYPsQEELIKV X X 9009 +ATM ATM Q13315 human TRF1 7013 P54274 TERF1 human S367 22996308 SRIPVSKsQPVtPEK X X +ATM ATM Q13315 human RAGE 11596 Q62151 Ager mouse S389 4731275 ERAELNQsEEAEMPE X X +ATM ATM Q13315 human GIT2 9815 Q14161 GIT2 human S384 30999681 NNQHsVEsQDNDQPd X +ATM ATM Q13315 human SCC-112 23244 Q29RF7 PDS5A human S1278 3965429 GRRPKsEsQGNATKN X +ATM ATM Q13315 human DCK 13178 P43346 Dck mouse S74 456305 EFEELTtsQKSGGNV dNK X X +ATM ATM Q13315 human BRCA1 672 P38398 BRCA1 human S1387 455495 EDCSGLSsQSDILTt X X +ATM ATM Q13315 human ATM 472 Q13315 ATM human S1893 467199 PANLDsEsEHFFRCC X X +ATM ATM Q13315 human COPS5 10987 Q92905 COPS5 human S320 33365506 EAIHGLMsQVIkDkL CSN5_C X X +ATM ATM Q13315 human RNF138 51444 Q8WVD3 RNF138 human S124 472443 IIPNFQIsQDsVGNS X +ATM ATM Q13315 human SLX4 84464 Q8IY92 SLX4 human S1271 11952922 sRSRDCSsQtQISSL X +ATM ATM Q13315 human ATF-2 1386 P15336 ATF2 human S490 455782 QSTEPALsQIVMAPS X +ATM ATM Q13315 human MDC1 9656 Q14676 MDC1 human T4 3965656 ____MEDtQAIDWDV X X +ATM ATM Q13315 human HIF1A 3091 Q16665 HIF1A human S696 17595900 NVLsVALsQRTtVPE X X +ATM ATM Q13315 human BLM 641 P54132 BLM human T99 450958 NAPAGQEtQRGGSkS BLM_N X X +ATM ATM Q13315 human USP28 57646 Q96RU2 USP28 human S720 11952928 SsQDYSTsQEPSVAS X +ATM ATM Q13315 human USP10 9100 Q14694 USP10 human T42 12483201 SGTVLCGtQAVDKLP X +ATM ATM Q13315 human Artemis 64421 Q96SD1 DCLRE1C human S645 457531 NLSTNADsQsssDFE X X +ATM ATM Q13315 human CREB 1385 P16220 CREB1 human S107 451811 sVDsVtDsQKRREIL pKID X X +ATM ATM Q13315 human EZH2 iso2 2146 Q15910-2 EZH2 human S734 29606713 LFFDYRYsQADALKY X X +ATM ATM Q13315 human UBR5 51366 O95071 UBR5 human S1532 11952918 SDQSSSSsQSQSSYI X +ATM ATM Q13315 human USP34 9736 Q70CQ2 USP34 human S718 11952930 ATHIAQGsQESCITR X +ATM ATM Q13315 human MDM2 4193 Q00987 MDM2 human S425 11956708 EtQDKEEsVESsLPL X +ATM ATM Q13315 human Smc1 8243 Q14683 SMC1A human S360 452414 RMEEEsQsQGRDLtL SMC_N X 4029 +ATM ATM Q13315 human KHDRBS1 10657 Q07666 KHDRBS1 human T61 3194543 GARAsPAtQPPPLLP X +ATM ATM Q13315 human HUWE1 10075 Q7Z6Z7 HUWE1 human S2636 4955267 HDQsTAtsQAGTLSS X +ATM ATM Q13315 human ATF-2 1386 P15336 ATF2 human S498 455783 QIVMAPSsQSQPSGS X +ATM ATM Q13315 human WAPL 23063 Q7Z5K2 WAPL human S305 22780675 RANKTkssQGASNFD X +ATM ATM Q13315 human DDX1 1653 Q92499 DDX1 human S671 36406800 EHLNCTIsQVEPDIK X X +ATM ATM Q13315 human p53 7157 P04637 TP53 human S33 447531 LPENNVLsPLPsQAM X 2526 +ATM ATM Q13315 human CtIP 225182 Q80YR6 Rbbp8 mouse T843 7113805 FRYIPPNtPENFWEV SAE2 X +ATM ATM Q13315 human TRF1 7013 P54274 TERF1 human S219 448475 SKLLMIIsQKDTFHS TRF X X +ATM ATM Q13315 human HNF1A 6927 P20823 HNF1A human S249 451310 IQRGVsPsQAQGLGS X X +ATM ATM Q13315 human ATM 472 Q13315 ATM human S440 486365 SPLLMILsQLLPQQR X +ATM ATM Q13315 human MDC1 9656 Q14676 MDC1 human T98 20583303 DCGsLNGtQILRPPK FHA X X +ATM ATM Q13315 human PPP2R5C 5527 Q13362 PPP2R5C human S520 18958501 CRADELAsQDGR___ X X +ATM ATM Q13315 human p63 22061 O88898 Tp63 mouse S41 27937106 SYYRSAMsQSTQTSE X +ATM ATM Q13315 human RIF1 55183 Q5UIP0 RIF1 human S1851 481963 sEAMsLEsQEsPNEN X +ATM ATM Q13315 human ATM 300711 D4ACL8 Atm rat S1988 448797 sPTFEEGsQGTTISS X +ATM ATM Q13315 human beclin 1 8678 Q14457 BECN1 human T57 4275031 AQAkPGEtQEEETNs X X +ATM ATM Q13315 human DYRK2 8445 Q92630 DYRK2 human T106 11489910 NKRTVLTtQPNGLTT X +ATM ATM Q13315 human MDM2 4193 Q00987 MDM2 human S395 447898 sQESEDysQPSTSSS X X +ATM ATM Q13315 human Smc1 8243 Q14683 SMC1A human S358 481894 EERMEEEsQsQGRDL SMC_N X +ATM ATM Q13315 human BRCA1 672 P38398 BRCA1 human S1423 448036 AVLEQHGsQPSNSYP X X +ATM ATM Q13315 human AATF 26574 Q9NY61 AATF human S189 3753300 EGDDAEDsQGEsEED X +ATM ATM Q13315 human MLLT1 4298 Q03111 MLLT1 human S398 40666502 FEPsQNHsQGPLRsM X +ATM ATM Q13315 human SMURF2 64750 Q9HAU4 SMURF2 human S384 1870790704 kILRQELsQQQPQAG X +ATM ATM Q13315 human Smc1 8243 Q14683 SMC1A human S966 448698 GEDsVsGsQRIssIy SMC_N X X +ATM ATM Q13315 human PELP1 27043 Q8IZL8 PELP1 human S1033 472322 LAPEALPsQGEVERE X +ATM ATM Q13315 human RAD17 5884 O75943 RAD17 human S646 447755 ETWSLPLsQNSASEL X X 13404 +ATM ATM Q13315 human PIDD 55367 Q9HB75 PIDD1 human T788 25680403 DAETGFLtQSNLLSV X X +ATM ATM Q13315 human Chk1 1111 O14757 CHEK1 human S345 447834 LVQGIsFsQPtCPDH X 2341; 2348; 12268; 76784 +ATM ATM Q13315 human 53BP1 7158 Q12888 TP53BP1 human S1219 481849 DDtEsLHsQGEEEFD X X +ATM ATM Q13315 human NIPBL 25836 Q6KC79 NIPBL human S553 1249849 HQAGRVDsQAsItQD X +ATM ATM Q13315 human TOPBP1 11073 Q92547 TOPBP1 human S554 11379601 ITEEGLFsQKSFLVL X +ATM ATM Q13315 human MED1 5469 Q15648 MED1 human S887 11952940 EEYFDESsQSGDNDD X +ATM ATM Q13315 human 53BP1 7158 Q12888 TP53BP1 human S25 450163 PCLIIEDsQPEsQVL X 2674 +ATM ATM Q13315 human SLX4 84464 Q8IY92 SLX4 human S1138 11952925 PDHsSSRsQKSSSKL X +ATM ATM Q13315 human CCDC6 8030 Q16204 CCDC6 human T434 479429 tPPPSPNtQTPVQPP X +ATM ATM Q13315 human RAGE 177 Q15109 AGER human S391 4731275 ERAELNQsEEPEAGE X +ATM ATM Q13315 human BAT3 7917 P46379 BAG6 human S218 11952931 PEPVALSsQTSEPVE X +ATM ATM Q13315 human MED1 5469 Q15648 MED1 human S1134 477909 LsSSMyssQGSSGSs X +ATM ATM Q13315 human TDP1 55775 Q9NUW8 TDP1 human S563 460794 KQKFFAGsQEPMATF Tyr-DNA_phospho X +ATM ATM Q13315 human BRCA1 672 P38398 BRCA1 human S1497 448730 EPGVERssPsKCPsL X +ATM ATM Q13315 human BUB1 699 O43683 BUB1 human S314 481705 sHEDLPAsQERSEVN X X +ATM ATM Q13315 human BRCA1 672 P38398 BRCA1 human S1189 450007 QKGELsRsPsPFtHT X +ATM ATM Q13315 human SARS 6301 P49591 SARS1 human S241 482693 MQEVAQLsQFDEELy X X +ATM ATM Q13315 human Fe65 322 O00213 APBB1 human S228 36841900 DSSWATLsQGSPSYG X +ATM ATM Q13315 human HIC1 3090 Q14526 HIC1 human S713 1872610000 DKAAEVLsQGAHLAA X +ATM ATM Q13315 human SMC3 9126 Q9UQE7 SMC3 human S383 1880758200 YAkQGRGsQFTsKEE X +ATM ATM Q13315 human DGCR8 54487 Q8WYQ5 DGCR8 human S677 1874101914 RVGKQLAsQKILQLL dsrm X X +ATM ATM Q13315 human SMARCC2 6601 Q8TAQ2 SMARCC2 human S969 15707400 PPALPPGsQPIPPTG X +ATM ATM Q13315 human USP10 9100 Q14694 USP10 human S337 12483200 ASGTLPVsQPKsWAS X +ATM ATM Q13315 human DNAPK 5591 P78527 PRKDC human T2638 448712 VAGQIRAtQQQHDFt DNAPKcs_CC5 X +ATM ATM Q13315 human UFL1 23376 O94874 UFL1 human S462 15436603 DDDsDDEsQssHtGK X +ATM ATM Q13315 human Artemis 64421 Q96SD1 DCLRE1C human S648 38410203 TNADsQsssDFEVPs X +ATM ATM Q13315 human SMAD1 4086 Q15797 SMAD1 human S239 25546600 DPMTQDGsQPMDTNM X X +ATM ATM Q13315 human VCP 7415 P55072 VCP human S326 3850834 EVERRIVsQLLtLMD AAA X +ATM ATM Q13315 human MCM3 4172 P25205 MCM3 human S535 475983 ATDDPNFsQEDQQDT X X +ATM ATM Q13315 human CBL 867 P22681 CBL human T640 23090718 DVPRLGstFsLDtsM X X +ATM ATM Q13315 human NBS1 4683 O60934 NBN human S343 448605 TtPGPsLsQGVsVDE X X 3001 +ATM ATM Q13315 human DNAPK 5591 P78527 PRKDC human T2609 448710 LtPMFVEtQAsQGtL DNAPKcs_CC5 X +ATM ATM Q13315 human SP1 6667 P08047 SP1 human S56 767910 tGGGGQEsQPsPLAL X +ATM ATM Q13315 human UBR5 51366 O95071 UBR5 human S191 11952917 VIPEELIsQAQVVLQ E3_UbLigase_EDD X +ATM ATM Q13315 human RANBP9 10048 Q96S59 RANBP9 human S603 482142 tEMEVDSsQLRRQLC CTLH X X +ATM ATM Q13315 human TOPBP1 11073 Q92547 TOPBP1 human T1062 460941 NDSkGVLtQtLEMRE X +ATM ATM Q13315 human SARS 6301 P49591 SARS1 human S101 23141783 ALANLkVsQIKKVRL Seryl_tRNA_N X X +ATM ATM Q13315 human NFAT5 10725 O94916 NFAT5 human S1197 452030 HIQTPMLsQEQAQPP X +ATM ATM Q13315 human Ku70 2547 P12956 XRCC6 human S27 449267 QEENLEAsGDykYsG X +ATM ATM Q13315 human TAO3 51347 Q9H2K8 TAOK3 human S359 468905 SMSVSTGsQSSSVNS X +ATM ATM Q13315 human USP28 57646 Q96RU2 USP28 human S495 11952927 STSTEsSsQDVESTF UCH X +ATM ATM Q13315 human BTRC 8945 Q9Y297 BTRC human S158 1872610002 EFVEHLIsQMCHYQH Beta-TrCP_D X +ATM ATM Q13315 human ITCH iso2 83737 Q96J02-2 ITCH human S161 33522000 TTCSESAsQNDDGSR X +ATM ATM Q13315 human METTL3 56339 Q86U44 METTL3 human S43 483736 rNPEAALsPTFRsDs X X +ATM ATM Q13315 human BANP 53325 Q8VBU8 Banp mouse S370 36440208 PTSELQQsQPQALHY X X +ATM ATM Q13315 human C1QBP 12261 O35658 C1qbp mouse S147 1783001 FDGEEEPsQGQKAEE MAM33 X +ATM ATM Q13315 human RFWD3 55159 Q6PCD5 RFWD3 human S63 11952912 APAEVISsQATPPLL X +ATM ATM Q13315 human ZNF148 7707 Q9UQR1 ZNF148 human S202 483978 GEkPFQCsQCDMRFI zf-C2H2 X X +ATM ATM Q13315 human Pnk1 11284 Q96T60 PNKP human S126 460833 PPGtPLVsQDEKRDA X X +ATM ATM Q13315 human RAP80 20184 Q5U5Q9 Uimc1 mouse S205 486299 SGSWDQSsQPVFENE X +ATM ATM Q13315 human RAD17 5884 O75943 RAD17 human T633 31894301 EESLGEPtQATVPET X X +ATM ATM Q13315 human RASSF1 11186 Q9NS23 RASSF1 human S135 486364 EWETPDLsQAEIEQk X X +ATM ATM Q13315 human NKX3-1 4824 Q99801 NKX3-1 human T134 28750701 SRAAFSHtQVIELER Homeodomain X +ATM ATM Q13315 human Abraxas 84142 Q6UWZ7 ABRAXAS1 human S406 3203163 GFGEYsRsPtF____ X +ATM ATM Q13315 human Artemis 64421 Q96SD1 DCLRE1C human S516 460660 SSTVAGGsQsPKLFS X X +ATM ATM Q13315 human CREB 1385 P16220 CREB1 human S119 448228 EILsRRPsyRkILND pKID X X 9187; 9196; 9198; 4095; 14228; 14001; 39561; 80120; 44864; 54960; 95995 +ATM ATM Q13315 human KHDRBS1 10657 Q07666 KHDRBS1 human S388 5832066 EGYEGYysQsQGDSE Sam68-YY X +ATM ATM Q13315 human SMC3 9126 Q9UQE7 SMC3 human S1065 453058 KkGDVEGsQsQDEGE SMC_N X +ATM ATM Q13315 human TAO3 51347 Q9H2K8 TAOK3 human S551 11952936 DLTTFLEsQKKQYKI X +ATM ATM Q13315 human UBR5 51366 O95071 UBR5 human S174 11952916 rGsGLLGsQPQPVIP X +ATM ATM Q13315 human SRPK1 6732 Q96SB4 SRPK1 human S408 1872827400 QNGDSSTsQETDSCT X +ATM ATM Q13315 human CREB iso1 1385 P16220-1 CREB1 human T100 457131 LKRLFsGtQISTIAE X +ATM ATM Q13315 human p27Kip1 1027 P46527 CDKN1B human S140 481797 PkTDPSDsQTGLAEQ X X +ATM ATM Q13315 human MED1 5469 Q15648 MED1 human S816 11952938 DSSSSGHsQSTLFDS X +ATM ATM Q13315 human CREB 1385 P16220 CREB1 human S97 451808 TIAEsEDsQEsVDsV X +ATM ATM Q13315 human BRCA1 672 P38398 BRCA1 human S1457 450008 SEKAVLTsQKsSEYP X X +ATM ATM Q13315 human EHMT2 10919 Q96KQ7 EHMT2 human S569 456315 APAPPPLsQDVPGRA X +ATM ATM Q13315 human COP1 64326 Q8NHY2 COP1 human S387 467307 SDDSRTAsQLDEFQE X X +ATM ATM Q13315 human CtIP 5932 Q99708 RBBP8 human S745 448392 SCLADSFsQAADEEE X +ATM ATM Q13315 human XPA 7507 P23025 XPA human S173 460697 VKkNPHHsQWGDMKL XPA_C X +ATM ATM Q13315 human RNF20 56254 Q5VTR2 RNF20 human S545 482124 PDsEDLSsQSsAsKA X +ATM ATM Q13315 human KIFC1 3833 Q9BW19 KIFC1 human S26 477789 RPLIkAPsQLPLsGs X +ATM ATM Q13315 human PKM 5315 P14618 PKM human T328 481749 GkPVICAtQMLESMI PK X +ATM ATM Q13315 human CHD-4 1108 Q14839 CHD4 human S1349 481897 QVNYNDGsQEDRDWQ DUF1087 X +ATM ATM Q13315 human MRE11A 4361 P49959 MRE11 human S676 460788 tSsskIMsQsQVsKG X X 4859 +ATM ATM Q13315 human SLX4 84464 Q8IY92 SLX4 human S1716 11952924 GSDSSLSsQSSSSCE X +ATM ATM Q13315 human ZNF420 147923 Q8TAQ5 ZNF420 human S68 7669300 NTYETELsQWEMSDR X +ATM ATM Q13315 human DNAPK 5591 P78527 PRKDC human T2647 448713 QQHDFtLtQTADGRs DNAPKcs_CC5 X +ATM ATM Q13315 human HUWE1 10075 Q7Z6Z7 HUWE1 human S3695 11952915 ENVVIVAsQkRPLGG X +ATM ATM Q13315 human DBN1 56320 Q9QXS6 Dbn1 mouse S658 472365 SEGyFsQsQEEEFAQ X +ATM ATM Q13315 human NUSAP1 51203 Q9BXS6 NUSAP1 human S124 482179 QNHEKQEsQDLRATA X +ATM ATM Q13315 human RAD18 56852 Q9NS91 RAD18 human S403 482231 TSVTNHFsQSKLDsP X 14978; 8393 +ATM ATM Q13315 human DNAPK 5591 P78527 PRKDC human S2612 448711 MFVEtQAsQGtLQtR DNAPKcs_CC5 X +ATM ATM Q13315 human Cortactin 2017 Q14247 CTTN human S113 465664 skLskHCsQVDsVrG HS1_rep X X +ATM ATM Q13315 human WHSC1 7468 O96028 NSD2 human S102 481737 DAkLRFEsQEMKGIG X +ATM ATM Q13315 human ZNF207 7756 O43670 ZNF207 human S104 56818116 LEQktQEsQKKKQQD X +ATM ATM Q13315 human USP34 9736 Q70CQ2 USP34 human S1751 11952929 NIHIkDAsQTTLLDL X +ATM ATM Q13315 human FMIP 8563 Q13769 THOC5 human S312 467901 EDsQDDEsDsDAEEE FmiP_Thoc5 X +ATM ATM Q13315 human MED1 5469 Q15648 MED1 human S874 11952943 PDLLNsQsQSGFGEE X +ATM ATM Q13315 human HSP90A 3320 P07900 HSP90AA1 human T5 448319 ___MPEEtQtQDQPM X 3488 +ATM ATM Q13315 human ZBTB2 57621 Q8N680 ZBTB2 human S115 11952921 IQEASLAsQGAFSHP BTB X +ATM ATM Q13315 human RNF40 9810 O75150 RNF40 human S819 11952909 EQVLGLksQVDAQLL X +ATM ATM Q13315 human KHDRBS1 10657 Q07666 KHDRBS1 human S390 34500272 YEGYysQsQGDSEyy Sam68-YY X +ATM ATM Q13315 human MDM2 4193 Q00987 MDM2 human T419 448132 KEFEREEtQDKEEsV X +ATM ATM Q13315 human Abraxas 84142 Q6UWZ7 ABRAXAS1 human S404 25173562 MkGFGEYsRsPtF__ X +ATM ATM Q13315 human p63 8626 Q9H3D4 TP63 human S479 4668107 MNKLPsVsQLINPQQ X X +ATM ATM Q13315 human DCK 1633 P27707 DCK human S74 456305 EFEELtMsQkNGGNV dNK X X 40371 +ATM ATM Q13315 human KHSRP 8570 Q92945 KHSRP human S274 482097 MILIQDGsQNtNVDk KH_1 X X +ATM ATM Q13315 human p53 24842 P10361 Tp53 rat S15 447490 MsIELPLsQEtFsCL P53_TAD X 9284; 9286; 12571; 56979 +ATM ATM Q13315 human BMAL1 406 O00327 BMAL1 human S183 1884110700 VFKILNYsQNDLIGQ X +ATM ATM Q13315 human IKKA 1147 O15111 CHUK human S473 487499 KNTLISAsQQLKAKL IKBKB_SDD X +ATM ATM Q13315 human DBF4 10926 Q9UBU7 DBF4 human T449 23010416 DDIRQNFtQLPLHkN X X +ATM ATM Q13315 human WRAP53 55135 Q9BUR4 WRAP53 human S64 482238 PVAGSAVsQELREGD X +ATM ATM Q13315 human KIBRA 23286 Q8IX03 WWC1 human T1006 54400801 RTWHSQLtQEISVLK X X +ATM ATM Q13315 human RNF40 9810 O75150 RNF40 human S114 18710201 ALLRCHEsQGELSSA X X +ATM ATM Q13315 human p53 7157 P04637 TP53 human S20 447529 PLsQEtFsDLWkLLP P53_TAD X 9287 +ATM ATM Q13315 human ESCO2 157570 Q56NI9 ESCO2 human S196 1881957102 SNAPRVLsQKIKPQV X +ATM ATM Q13315 human MRE11A 4361 P49959 MRE11 human S264 486366 EQQLFYIsQPGSSVV X +ATM ATM Q13315 human GLUT1 6513 P11166 SLC2A1 human S490 477830 FHPLGADsQV_____ X X +ATM ATM Q13315 human USP15 9958 Q9Y4E8 USP15 human S678 11952926 LPSENENsQSEDSVG UCH X +ATM ATM Q13315 human LARP7 51574 Q4G0J3 LARP7 human T440 1869962000 ANREECRtQEKVNAt X +ATM ATM Q13315 human RFA2 6118 P15927 RPA2 human S23 448337 GAGGYtQsPGGFGsP X +ATM ATM Q13315 human BRCA1 672 P38398 BRCA1 human S1542 450009 EEQQLEEsGPHDLtE X +ATM ATM Q13315 human Chk2 11200 O96017 CHEK2 human S35 447550 sQGSSsQsQGIssss X 2665 +ATM ATM Q13315 human TDP1 55775 Q9NUW8 TDP1 human S365 11952937 TPGrFQGsQkDNWGH Tyr-DNA_phospho X +ATM ATM Q13315 human BLM 641 P54132 BLM human T122 450959 PKEVVCTtQNtPtVk BLM_N X +ATM ATM Q13315 human SIM2 6493 Q14190 SIM2 human S115 1385533600 ASVHLGLsQVELTGN PAS X +ATM ATM Q13315 human RASSF1 iso2 11186 Q9NS23-2 RASSF1 human S131 486364 EWETPDLsQAEIEQK X X +ATM ATM Q13315 human RANBP9 10048 Q96S59 RANBP9 human S181 54363506 kFSYIGLsQNNLRVH X X +ATM ATM Q13315 human RAP80 20184 Q5U5Q9 Uimc1 mouse S402 482139 TTSRGQSsQGLFVEE X +ATM ATM Q13315 human SMC3 9126 Q9UQE7 SMC3 human S787 482312 ELGtDLLsQLsLEDQ SMC_N X +ATM ATM Q13315 human UBR5 51366 O95071 UBR5 human S1679 11952919 SDSDSSSsQSDDIEQ X +ATM ATM Q13315 human FBXO31 79791 Q5XUX0 FBXO31 human S278 13216200 LMKFIytsQYDNCLt X X +ATM ATM Q13315 human GIT2 9815 Q14161 GIT2 human T195 38539203 VYGADPGtQDSSGKT Ank_2 X +ATM ATM Q13315 human ATM 472 Q13315 ATM human S1981 448797 sLAFEEGsQSTtIss X X 4526; 5883; 13050 +ATM ATM Q13315 human MYST1 84148 Q9H7Z6 KAT8 human T392 34424910 LSQMTSItQNDIIST MOZ_SAS X X +ATM ATM Q13315 human USP2 9099 O75604 USP2 human T137 1880716200 YDQGVTLtQKLDsQs X +ATM ATM Q13315 human USP28 57646 Q96RU2 USP28 human S714 467253 ESSTNSSsQDYSTsQ X +ATM ATM Q13315 human RFWD3 55159 Q6PCD5 RFWD3 human S46 11952911 VPADVVSsQGVPSIL X +ATM ATM Q13315 human Smc1 8243 Q14683 SMC1A human S951 460802 kGtMDDIsQEEGssQ SMC_N X +ATM ATM Q13315 human p300 2033 Q09472 EP300 human S106 14652802 GPGQVMAsQAQQSSP X X +ATM ATM Q13315 human RAD50 10111 Q92878 RAD50 human S635 453831 KLFDVCGsQDFEsDL X X 14223; 74778 +ATM ATM Q13315 human DNAPK 5591 P78527 PRKDC human S3205 452351 tPLPEDNsMNVDQDG FAT X +ATM ATM Q13315 human NBS1 4683 O60934 NBN human S278 449968 VDTGITNsQTLIPDC NIBRIN_BRCT_II X X +ATM ATM Q13315 human TIF1B 10155 Q13263 TRIM28 human S824 460839 LPGAGLssQELsGGP X 4127 +ATM ATM Q13315 human Chk2 11200 O96017 CHEK2 human T68 447491 SsLEtVstQELYsIP X X 2197; 2661; 28130; 12812; 82263; 64180; 59068 +ATM ATM Q13315 human Ku70 2547 P12956 XRCC6 human S33 50247606 AsGDykYsGRDsLIF X +ATM ATM Q13315 human SRPK1 6732 Q96SB4 SRPK1 human T326 25724401 ENPPNKMtQEKLEEs X +ATM ATM Q13315 human TET1 80312 Q8NFU7 TET1 human S1971 1881549502 SEADEPPsDEPLsDD X X +ATM ATM Q13315 human FANCI 55215 Q9NVI1 FANCI human S559 11952935 SLSSsQCsQSLSVsQ FANCI_HD2 X +ATM ATM Q13315 human RFA2 6118 P15927 RPA2 human T21 448340 yGGAGGYtQsPGGFG X X +ATM ATM Q13315 human TTC5 219022 Q99LG4 Ttc5 mouse S203 12559514 TGQNPKIsQQALSAY X +ATM ATM Q13315 human H2AX 3014 P16104 H2AX human S139 448841 GkkAtQAsQEy____ X 2577; 9719; 9720; 9718; 4309; 5763; 5438; 93629; 80312; 20304; 85410; 97148; 60566; 59141 +ATM ATM Q13315 human TAO1 57551 Q7L7X3 TAOK1 human T785 3627516 SINEMLStQALRLDE X +ATM ATM Q13315 human ESCO2 157570 Q56NI9 ESCO2 human T233 1881957104 NEPSLGRtQKSKSEV X +ATM ATM Q13315 human RNF20 56254 Q5VTR2 RNF20 human S522 3201825 sGsALLQsQsstEDP X +ATM ATM Q13315 human GLTSCR2 29997 Q9NZM5 NOP53 human T289 60120300 PATEQAAtQESTFQE Nop53 X +ATM ATM Q13315 human GLTSCR2 29997 Q9NZM5 NOP53 human S233 23110061 ARLHTKPsQAPAVEV Nop53 X +ATM ATM Q13315 human MDM4 4194 O15151 MDM4 human S403 474540 DLAHSSEsQETISSM X X +ATM ATM Q13315 human RAD17 5884 O75943 RAD17 human S656 447756 SASELPAsQPQPFSA X X 6981 +ATM ATM Q13315 human NHEJ1 79840 Q9H9Q4 NHEJ1 human S251 4084900 AsLQGIDsQCVNQPE X +ATM ATM Q13315 human WRN 7486 Q14191 WRN human S1141 481875 PEKAYSSsQPVISAQ X +ATM ATM Q13315 human AMPKA2 5563 P54646 PRKAA2 human T172 448026 sDGEFLRtsCGsPNy Pkinase X 2535; 2531; 5256; 50081; 74281 +ATM ATM Q13315 human DNAPK 5591 P78527 PRKDC human T4102 1881979000 EsGLSEEtQVkCLMD X X +ATM ATM Q13315 human CtIP 225182 Q80YR6 Rbbp8 mouse T855 27427901 WEVGFPStQTCLERG SAE2 X +ATM ATM Q13315 human MED1 5469 Q15648 MED1 human S1147 11952941 SsQSKNSsQsGGKPG X +ATM ATM Q13315 human TOPBP1 11073 Q92547 TOPBP1 human S492 460804 QADEDLLsQyENGss X +ATM ATM Q13315 human separase 9700 Q14674 ESPL1 human S1660 1269647504 ADQLQGLsLQEMPGD X X +ATM ATM Q13315 human DAXX 1616 Q9UER7 DAXX human S564 27571800 LEEESPVsQLFELEI X X +ATM ATM Q13315 human 4E-BP1 1978 Q13541 EIF4EBP1 human S94 476291 DEPPMEAsQSHLRNs eIF_4EBP X +ATM ATM Q13315 human TRIM24 8805 O15164 TRIM24 human S768 481699 TsLLLNSsQSstSEE X X +ATM ATM Q13315 human HBXIP 10542 O43504 LAMTOR5 human S26 482652 VGVLCTDsQGLNLGC LAMTOR5 X X +ATM ATM Q13315 human FMIP 8563 Q13769 THOC5 human S314 467902 sQDDEsDsDAEEEQt FmiP_Thoc5 X +ATM ATM Q13315 human DBF4 10926 Q9UBU7 DBF4 human S539 482262 GLItINSsQEHLTVQ X X +ATM ATM Q13315 human Chk2 11200 O96017 CHEK2 human T26 447547 sQPHGsVtQsQGSSs X +ATM ATM Q13315 human NBS1 4683 O60934 NBN human S615 460790 VPEssKIsQENEIGK X X +ATM ATM Q13315 human p53 7157 P04637 TP53 human S15 447490 PsVEPPLsQEtFsDL P53_TAD X X 4030; 9235; 9284; 9286; 8695; 8514; 82530; 56979 +ATM ATM Q13315 human NFAT5 10725 O94916 NFAT5 human S1367 452032 LVQGSPSsQEQQVTL X +ATM ATM Q13315 human TOPBP1 11073 Q92547 TOPBP1 human S1138 482079 PDVNTEPsQNEQIIW X +ATM ATM Q13315 human SMARCA4 6597 P51532 SMARCA4 human S721 481804 VDDEyGVsQALARGL X X +ATM ATM Q13315 human TDP1 55775 Q9NUW8 TDP1 human S81 11279401 PKRQKsGsQEDLGWC X X +ATM ATM Q13315 human PTEN 5728 P60484 PTEN human S113 33636428 EDLDQWLsEDDNHVA X X +ATM ATM Q13315 human NBS1 4683 O60934 NBN human S397 460791 EQKFRMLsQDAPtVK X X +ATM ATM Q13315 human RNF20 56254 Q5VTR2 RNF20 human S172 18710200 SSSEEMEsQLQERVE X X +ATM ATM Q13315 human UBR5 51366 O95071 UBR5 human S2586 11952920 LRQLILAsQSSDADA HECT X +ATM ATM Q13315 human BUB3 9184 O43684 BUB3 human S135 1876205008 PCNAGtFsQPEkVyT X X +ATM ATM Q13315 human COPS3 26572 O88543 Cops3 mouse S410 482300 FVQKsMGsQEDDSGN X +ATM ATM Q13315 human Artemis 64421 Q96SD1 DCLRE1C human S647 38410204 STNADsQsssDFEVP X +ATM ATM Q13315 human DYRK2 8445 Q92630 DYRK2 human S442 11489909 IELLGMPsQKLLDAs Pkinase X +ATM ATM Q13315 human SIAH1 6477 Q8IUQ4 SIAH1 human S19 2840508 GtSkCPPsQRVPALT X X +ATM ATM Q13315 human EWS 2130 Q01844 EWSR1 human T79 7359501 QPPTGYTtPTAPQAY X +ATM ATM Q13315 human COPS1 2873 Q13098 GPS1 human S474 467704 ksPPREGsQGELtPA X +ATM ATM Q13315 human USP52 9924 Q504Q3 PAN2 human S1003 50792538 TKSTIkPsQMSVARI RNase_T X X +ATM ATM Q13315 human RAD9A 5883 Q99638 RAD9A human S272 447824 LSDtDSHsQDLGsPE X X +ATM ATM Q13315 human MLH1 4292 P40692 MLH1 human S406 12217082 PLSkPLSsQPQAIVT X +ATM ATM Q13315 human FMIP 8563 Q13769 THOC5 human S307 467900 LFKPPEDsQDDEsDs FmiP_Thoc5 X +ATM ATM Q13315 human TRIM24 8805 O15164 TRIM24 human S808 3174917 kSEWLDPsQKsPLHV X X +ATM ATM Q13315 human NBS1 27354 Q9R207 Nbn mouse T278 449968 VDVGITNtQLIISHS NIBRIN_BRCT_II X +ATM ATM Q13315 human FANCI 55215 Q9NVI1 FANCI human S556 11952934 VLGSLSSsQCsQSLS FANCI_HD2 X +ATM ATM Q13315 human MLLT1 4298 Q03111 MLLT1 human S394 40666501 SDSDFEPsQNHsQGP X +ATM ATM Q13315 human polybromo 1 55193 Q86U86 PBRM1 human S948 453717 SGLHRTYsQDCSFKN X 82088 +ATM ATM Q13315 human EYA3 2140 Q99504 EYA3 human S266 460853 PSTsPsLsQttPsKD X +ATM ATM Q13315 human USP28 57646 Q96RU2 USP28 human S67 467252 DERVkEPsQDtVATE X +ATM ATM Q13315 human UBQLN4 56893 Q9NRR5 UBQLN4 human S318 482228 GNSDsSSsQPLRTEN X +ATM ATM Q13315 human MED1 5469 Q15648 MED1 human S953 481921 LMEHHsGsQGPLLTT X +ATM ATM Q13315 human MDM2 4193 Q00987 MDM2 human S429 11956707 KEEsVESsLPLNAIE X X +ATM ATM Q13315 human PPP2R1A 51792 Q76MZ3 Ppp2r1a mouse S401 1880515600 VIGIRQLsQSLLPAI X X +ATM ATM Q13315 human DDX1 1653 Q92499 DDX1 human S377 36406801 DEADGLLsQGysDFI DEAD X X +ATM ATM Q13315 human SPOP 8405 O43791 SPOP human S119 1874115101 EETKAMEsQRAYRFV MATH X +ATM ATM Q13315 human matrin 3 9782 P43243 MATR3 human S208 452690 DyDHGsRsQEsGyyD X +ATM ATM Q13315 human PEX5 5830 P50542 PEX5 human S141 50389701 DYNETDWsQEFISEV X +NTRK1 TrkA P04629 human SH2-B-beta 25970 Q9NRF2 SH2B1 human Y753 408589400 PRAINNQySFV____ X +NTRK1 TrkA P04629 human CTNNB1 1499 P35222 CTNNB1 human Y142 449044 AVVNLINyQDDAELA X X +NTRK1 TrkA P04629 human TrkA iso2 4914 P04629-2 NTRK1 human Y490 447762 HIIENPQyFSDACVH X 9141; 4619 +NTRK1 TrkA P04629 human TrkA iso2 4914 P04629-2 NTRK1 human Y674 447763 RDIySTDyyRVGGRT PK_Tyr_Ser-Thr X +NTRK1 TrkA P04629 human TrkA 4914 P04629 NTRK1 human Y680 447763 RDIySTDyyRVGGRT PK_Tyr_Ser-Thr X X 4621 +NTRK1 TrkA P04629 human SHC3 iso2 53358 Q92529-2 SHC3 human Y218 451254 GDGSDHPyyNSIPSK X +NTRK1 TrkA P04629 human SHC3 iso2 53358 Q92529-2 SHC3 human Y256 451255 FAGKEQTyyQGRHLG X +NTRK1 TrkA P04629 human TrkA iso2 4914 P04629-2 NTRK1 human Y670 449759 FGMSRDIySTDyyRV PK_Tyr_Ser-Thr X +NTRK1 TrkA P04629 human TrkA 4914 P04629 NTRK1 human Y496 447762 HIIENPQyFSDACVH X 9141; 4619 +NTRK1 TrkA P04629 human STAT3 6774 P40763 STAT3 human Y705 448192 DPGsAAPyLktKFIC X X 4093; 9145; 4324; 9131; 9138; 4323; 4074; 4113; 48313; 20977; 25023; 8119; 52075; 52527; 73533; 61958; 73452; 16185; 74309 +NTRK1 TrkA P04629 human SHC1 iso2 6464 P29353-2 SHC1 human Y317 448511 ELFDDPSyVNVQNLD X +NTRK1 TrkA P04629 human PLCG1 5335 P19174 PLCG1 human Y771 448575 IGtAEPdyGALyEGR X +NTRK1 TrkA P04629 human PLCG1 5335 P19174 PLCG1 human Y783 447667 EGRNPGFyVEANPMP X 2821; 14461; 14008; 25678; 88717 +NTRK1 TrkA P04629 human TrkA iso2 4914 P04629-2 NTRK1 human Y675 447764 DIySTDyyRVGGRTM PK_Tyr_Ser-Thr X +NTRK1 TrkA P04629 human TrkA iso2 4914 P04629-2 NTRK1 human Y751 449758 RACPPEVyAIMRGCW PK_Tyr_Ser-Thr X +NTRK1 TrkA P04629 human TrkA 4914 P04629 NTRK1 human Y681 447764 DIySTDyyRVGGRTM PK_Tyr_Ser-Thr X X 4621 +NTRK1 TrkA P04629 human TrkA iso2 4914 P04629-2 NTRK1 human Y785 447765 LAQAPPVyLDVLG__ X 4168 +NTRK1 TrkA P04629 human SHC3 iso2 53358 Q92529-2 SHC3 human Y301 451259 PTGEAPTyVNTQQIP X +NTRK1 TrkA P04629 human SHC3 iso2 53358 Q92529-2 SHC3 human Y257 451256 AGKEQTyyQGRHLGD X +NTRK1 TrkA P04629 human SHC3 iso2 53358 Q92529-2 SHC3 human Y283 451257 RQGSSDIySTPEGKL X +NTRK1 TrkA P04629 human SHC3 iso2 53358 Q92529-2 SHC3 human Y219 451258 DGSDHPyyNSIPSKM X +Wee1 Wee1 P47810 mouse CDK1 12534 P11440 Cdk1 mouse Y15 447610 EKIGEGtyGVVyKGR Pkinase X 4539; 9111; 14566; 77897 +PKN3 PKN3 Q6P5Z2 human EGFR 1956 P00533 EGFR human T678 448053 RHIVRKRtLRRLLQE X 14343 +PKN3 PKN3 Q6P5Z2 human Restin 6249 P30622 CLIP1 human S312 4769833 AsLKRsPsAssLsSM X +MAP2K1 MEK1 P29678 rabbit MEK1 100009316 P29678 MAP2K1 rabbit Y300 2133800 PGRPLsSyGMDSRPP Pkinase X +MAP2K1 MEK1 P29678 rabbit ERK2 26413 P63085 Mapk1 mouse Y185 447594 HtGFLtEyVAtRWYR Pkinase X 9106; 4370; 4374; 9101; 4375; 4376; 4377; 3510; 5726; 88569; 13214; 13148; 70235; 9488; 89967; 8544; 14196; 14227; 14095; 14474; 75165; 98168; 33370; 54240; 15892; 45899; 55088; 9524; 69217; 48735 +MAP2K1 MEK1 P29678 rabbit MEK1 100009316 P29678 MAP2K1 rabbit S298 448284 RtPGRPLsSyGMDSR Pkinase X +MAP2K1 MEK1 P29678 rabbit ERK2 26413 P63085 Mapk1 mouse T183 447593 HDHtGFLtEyVAtRW Pkinase X 9106; 4370; 4374; 9101; 4375; 4376; 4377; 3510; 5726; 88569; 13214; 13148; 70235; 9488; 89967; 8544; 14196; 14227; 14095; 14474; 75165; 98168; 33370; 54240; 15892; 45899; 55088; 9524; 69217; 48735 +MAP2K1 MEK1 P29678 rabbit ERK2 116590 P63086 Mapk1 rat T183 447593 HDHtGFLtEyVAtRW Pkinase X 9106; 4370; 4374; 9101; 4375; 4376; 4377; 3510; 5726; 88569; 13214; 13148; 70235; 9488; 89967; 8544; 14196; 14227; 14095; 14474; 75165; 98168; 33370; 54240; 15892; 45899; 55088; 9524; 69217; 48735 +MAP2K1 MEK1 P29678 rabbit ERK1 5595 P27361 MAPK3 human T202 447542 HDHtGFLtEyVAtRW Pkinase X 9106; 4370; 4374; 9101; 4375; 4376; 4377; 3510; 5726; 88569; 13214; 13148; 70235; 9488; 89967; 8544; 14196; 14227; 14095; 14474; 75165; 98168; 33370; 54240; 15892; 45899; 55088; 9524; 69217; 48735 +MAP2K1 MEK1 P29678 rabbit ERK1 5595 P27361 MAPK3 human Y204 447543 HtGFLtEyVAtRWyr Pkinase X 9106; 4370; 4374; 9101; 4375; 4376; 4377; 3510; 5726; 88569; 13214; 13148; 70235; 9488; 89967; 8544; 14196; 14227; 14095; 14474; 75165; 98168; 33370; 54240; 15892; 45899; 55088; 9524; 69217; 48735 +Atm ATM Q62388 mouse MCM3 17215 P25206 Mcm3 mouse S732 475062 sQEKtDDsQEtQDsQ X +Atm ATM Q62388 mouse MCM3 17215 P25206 Mcm3 mouse S725 475061 HtPKtDDsQEKtDDs X +Atm ATM Q62388 mouse LKB1 20869 Q9WTK7 Stk11 mouse T366 448151 IEDGIIytQDFTVPG X X +Atm ATM Q62388 mouse MCM3 4172 P25205 MCM3 human S728 475062 HtPKtADsQETkEsQ X +Atm ATM Q62388 mouse PTEN 19211 O08586 Pten mouse S398 4695758 PFDEDQHsQITKV__ X +Atm ATM Q62388 mouse MDM2 4193 Q00987 MDM2 human S395 447898 sQESEDysQPSTSSS X +Atm ATM Q62388 mouse LKB1 20869 Q9WTK7 Stk11 mouse S431 448147 sNKIRRLsACKQQ__ X X 3482 +Atm ATM Q62388 mouse IKKG 8517 Q9Y6K9 IKBKG human S85 458399 ELLHFQAsQREEKEF NEMO X X +Atm ATM Q62388 mouse p53 22059 P02340 Tp53 mouse S18 447490 IsLELPLsQEtFsGL P53_TAD X 9284; 9286; 12571; 56979 +Atm ATM Q62388 mouse Abl 25 P00519 ABL1 human S446 450296 PYPGIDLsQVYELLE PK_Tyr_Ser-Thr X +Atm ATM Q62388 mouse CREB 12912 Q01147 Creb1 mouse S107 451811 sVDsVTDsQKRREIL pKID X +Atm ATM Q62388 mouse SYN1 iso3 20964 O88935-3 Syn1 mouse S656 472577 APPRPSLsQDEVKAE X +Atm ATM Q62388 mouse ATM 11920 Q62388 Atm mouse S1987 448797 SPTFEEGsQGTTIsS X X +Atm ATM Q62388 mouse Smc1 24061 Q9CU62 Smc1a mouse S957 448697 ISQEEGSsQGEESVS SMC_N X 4805; 58052 +Atm ATM Q62388 mouse H2AX 15270 P27661 H2ax mouse S139 448841 GkKAsQAsQEy____ X X 2577; 9719; 9720; 9718; 4309; 5763; 5438; 93629; 80312; 20304; 85410; 97148; 60566; 59141 +Atm ATM Q62388 mouse CtIP 225182 Q80YR6 Rbbp8 mouse T855 27427901 WEVGFPStQTCLERG SAE2 X +Atm ATM Q62388 mouse USP15 14479 Q8R5H1 Usp15 mouse S678 11952926 LPSENENsQSEDSVG UCH X +Atm ATM Q62388 mouse p53 7157 P04637 TP53 human S15 447490 PsVEPPLsQEtFsDL P53_TAD X 4030; 9235; 9284; 9286; 8695; 8514; 82530; 56979 +Atm ATM Q62388 mouse TIF1B 21849 Q62318 Trim28 mouse S824 460839 LPSAGLssQELSGPG X 4127 +MAPK13 P38D O15264 human MAFA O57342 MAFA quail T57 456028 LSSTPLStPCSSVPS X X +MAPK13 P38D O15264 human MEF2D 4209 Q14814 MEF2D human S180 449933 LTDPRLLsPQQPALQ X +MAPK13 P38D O15264 human PSD-95 29495 P31016 Dlg4 rat T287 469607 TDyPtAMtPTsPRRY PDZ_assoc X +MAPK13 P38D O15264 human PRKD1 18760 Q62101 Prkd1 mouse S403 4169976 EDSNRtIsPstsNNI X +MAPK13 P38D O15264 human EEF2K 29904 O00418 EEF2K human S396 450812 TFDsLPssPssAtPH X +MAPK13 P38D O15264 human Tau iso8 4137 P10636-8 MAPT human S396 449081 GAEIVyKsPVVsGDt X 9632 +MAPK13 P38D O15264 human Tau iso8 4137 P10636-8 MAPT human S404 449082 PVVsGDtsPRHLsNV X 35834; 20194; 98523; 91600; 49562 +MAPK13 P38D O15264 human MEF2D 4209 Q14814 MEF2D human S121 2246700 EDKyRRAsEELDGLF HJURP_C X +MAPK13 P38D O15264 human PRKD1 18760 Q62101 Prkd1 mouse S407 3196826 RtIsPstsNNIPLMR X +MAPK13 P38D O15264 human MEF2D 4209 Q14814 MEF2D human S251 3196577 NkVIPAksPPPPtHS X +MAPK13 P38D O15264 human STMN1 3925 P16949 STMN1 human S25 448555 QAFELILsPrskEsV Stathmin X X +MAPK13 P38D O15264 human ISL1 3670 P61371 ISL1 human S269 515814094 GTPMVAAsPERHDGG X +MAPK13 P38D O15264 human MEF2D 4209 Q14814 MEF2D human S275 1883583402 PDLRVITsQAGKGLM X +MAPK13 P38D O15264 human STMN1 3925 P16949 STMN1 human S38 448556 sVPEFPLsPPkKkDL Stathmin X X 3426; 4191 +MAPK13 P38D O15264 human SQSTM1 8878 Q13501 SQSTM1 human T269 457004 GGkRsRLtPVsPEss X X 13121 +MAPK13 P38D O15264 human CCND3 896 P30281 CCND3 human T283 452160 QGPsQtstPtDVtAI X 53966 +MAPK13 P38D O15264 human MAFA O57342 MAFA quail T113 456029 NPEALNLtPEDAVEA Maf_N X X +MAPK13 P38D O15264 human PRKD1 18760 Q62101 Prkd1 mouse S748 448590 GEksFRRsVVGtPAy Pkinase X 2054 +MAPK13 P38D O15264 human DLG1 25252 Q62696 Dlg1 rat T209 35547401 VNTDSLEtPTYVNGT MAGUK_N_PEST X +MAPK13 P38D O15264 human MEF2D 4209 Q14814 MEF2D human S472 31862283 EPGDGLssPAGGSYE X +MAPK13 P38D O15264 human GYS1 2997 P13807 GYS1 human S723 4787599 sssLStPsEPLsPts X +MAPK13 P38D O15264 human EEF2K 29904 O00418 EEF2K human S359 447826 GtEEKCGsPQVRtLs X X +MAPK13 P38D O15264 human Tau iso8 4137 P10636-8 MAPT human T217 449078 sRtPsLPtPPtREPK X 33134; 51625 +MAPK13 P38D O15264 human HSF1 3297 Q00613 HSF1 human S307 449046 EPPsPPQsPRVEEAs Vert_HS_TF X +MAPK13 P38D O15264 human DLG1 25252 Q62696 Dlg1 rat S442 5931300 YLGQTPAsPARYsPI PDZ_assoc X +MAPK13 P38D O15264 human STMN1 29332 P13668 Stmn1 rat S25 448555 QAFELILsPRSKESV Stathmin X +MAPK13 P38D O15264 human NALP1 22861 Q9C000 NLRP1 human S107 1880261804 PSEPHLGsPSQPTST X +MAPK13 P38D O15264 human MEF2D 4209 Q14814 MEF2D human S444 449407 SIkSEPVsPsRERsP X X +MAPK13 P38D O15264 human HSF1 3297 Q00613 HSF1 human S303 449045 RVkEEPPsPPQsPRV Vert_HS_TF X +MAPK13 P38D O15264 human Tip60 iso2 10524 Q92993-2 KAT5 human T106 10800707 VEVVsPAtPVPSETA X X +MAPK13 P38D O15264 human DLG1 25252 Q62696 Dlg1 rat S158 2024309 FVSHSHIsPIKPTEA MAGUK_N_PEST X +MAPK13 P38D O15264 human PRKD1 18760 Q62101 Prkd1 mouse S203 449896 GVRRRRLsNVsLTGL X +MAPK13 P38D O15264 human Tau iso8 4137 P10636-8 MAPT human T212 447934 tPGsRsRtPsLPtPP X +MAPK13 P38D O15264 human GYS1 2997 P13807 GYS1 human S727 457615 StPsEPLsPtssLGE X +MAPK13 P38D O15264 human MEF2D 4209 Q14814 MEF2D human S231 3196574 GYVsARAsPGLLPVA X +MAPK13 P38D O15264 human HSF1 3297 Q00613 HSF1 human S326 455484 ssVDtLLsPTALIDs Vert_HS_TF X +MAPK13 P38D O15264 human PRKD1 18760 Q62101 Prkd1 mouse S255 449897 GREKRsNsQSYIGRP X +MAPK13 P38D O15264 human MAFA O57342 MAFA quail S272 456030 RGFPRETsPPAAPKT X X +MAPK13 P38D O15264 human GYS1 2997 P13807 GYS1 human T278 1875332700 kRkPDIVtPNGLNVk Glycogen_syn X +MAPK13 P38D O15264 human SQSTM1 8878 Q13501 SQSTM1 human S272 454787 RsRLtPVsPEssstE X X 13121 +MAPK13 P38D O15264 human Tip60 10524 Q92993 KAT5 human T158 10800707 VEVVsPAtPVPSETA X X +MAPK13 P38D O15264 human PRKD1 18760 Q62101 Prkd1 mouse S206 455754 RRRLsNVsLTGLGtV X +MYO3A MYO3A Q8NEV4 human MYO3A 53904 Q8NEV4 MYO3A human T919 29674701 TRHARETtNMKTQTV Myosin_head X +MYO3A MYO3A Q8NEV4 human MYO3A 53904 Q8NEV4 MYO3A human T184 29674700 stRHRRNtSVGtPFW Pkinase X +MYO3A MYO3A Q8NEV4 human MYO3A 53904 Q8NEV4 MYO3A human T908 29674702 INLAKGDtGEATRHA Myosin_head X +MYO3A MYO3A Q8NEV4 human MYO3A 53904 Q8NEV4 MYO3A human T178 23252211 VSAQLTstRHRRNtS Pkinase X +MYO3A MYO3A Q8NEV4 human MYO3A 53904 Q8NEV4 MYO3A human T188 36841901 RRNtSVGtPFWMAPE Pkinase X +FYN Fyn P06241 human DAB1 iso1 ABR15760 DAB1 pig Y197 447961 SQKKEGVyDVPKSQP X +FYN Fyn P06241 human NMDAR2A 2903 Q12879 GRIN2A human Y1118 11267004 SSPRDKIyTIDGEKE NMDAR2_C X +FYN Fyn P06241 human ITCH 83737 Q96J02 ITCH human Y420 454077 QFNQRFIyGNQDLFA X +FYN Fyn P06241 human NMT1 4836 P30419 NMT1 human Y180 10336300 YTLLNENyVEDDDNM NMT X +FYN Fyn P06241 human DCBLD2 131566 Q96PD2 DCBLD2 human Y750 454600 PAPDELVyQVPQStQ X +FYN Fyn P06241 human DCC 25311 Q63155 Dcc rat Y1261 454410 PTLESAQyPGILPsP Neogenin_C X +FYN Fyn P06241 human CD5 921 P06127 CD5 human Y453 447774 AsHVDNEysQPPRNs X +FYN Fyn P06241 human SLAP-130 2533 O15117 FYB1 human Y651 452095 LDMGDEVyDDVDTSD X +FYN Fyn P06241 human SLAP-130 2533 O15117 FYB1 human Y625 23144933 PPPDDDIydGIEEED X +FYN Fyn P06241 human PLCG2 5336 P16885 PLCG2 human Y753 447940 ERDINSLyDVsRMyV X +FYN Fyn P06241 human Abl 25 P00519 ABL1 human Y393 450298 RLMtGDtytAHAGAk PK_Tyr_Ser-Thr X 2865 +FYN Fyn P06241 human IFITM3 10410 Q01628 IFITM3 human Y20 463584 NSGQPPNyEMLkEEH X +FYN Fyn P06241 human DCBLD2 131566 Q96PD2 DCBLD2 human Y715 455062 PPPLVGtyNtLLsRt X +FYN Fyn P06241 human ARHGAP3 1124 P52757 CHN2 human Y21 482808 VSSDAEEyQPPIWKS X X +FYN Fyn P06241 human SNX26 115703 O14559 ARHGAP33 human Y406 465993 PLLTYQLyGKFSEAM RhoGAP X +FYN Fyn P06241 human NMDAR2A 2903 Q12879 GRIN2A human Y1246 458210 CLRMGNLyDIDEDQM NMDAR2_C X 4206 +FYN Fyn P06241 human Ig-alpha 12518 P11911 Cd79a mouse Y182 473649 DyEDENLyEGLNLDD ITAM X 14948; 5173; 14732; 29742; 52821; 17749 +FYN Fyn P06241 human PAG 55824 Q9NWQ8 PAG1 human Y317 450659 EEEIsAMyssVNKPG PAG X +FYN Fyn P06241 human SKAP55 8631 Q86WV1 SKAP1 human Y232 451308 EEEKEETyDDIDGFD X +FYN Fyn P06241 human DCBLD2 131566 Q96PD2 DCBLD2 human Y565 458665 KKkTEGtyDLPyWDR X +FYN Fyn P06241 human NMDAR2A 2903 Q12879 GRIN2A human Y1105 4109553 CSEVERTyLKTKSSS NMDAR2_C X +FYN Fyn P06241 human DCBLD2 131566 Q96PD2 DCBLD2 human S657 1869653003 ADLDPyNsPGQEVyH X +FYN Fyn P06241 human DAB1 iso2 13131 P97318-2 Dab1 mouse Y200 447960 VEDPVyQyIVFEAGH X +FYN Fyn P06241 human CRMP-1 1400 Q14194 CRMP1 human Y504 454682 GMyDGPVyEVPAtPK X +FYN Fyn P06241 human SCN5A 6331 Q14524 SCN5A human Y1494 455659 MTEEQKkyyNAMKKL X +FYN Fyn P06241 human PECAM-1 5175 P16284 PECAM1 human Y690 448759 PLNsDVQytEVQVSS X +FYN Fyn P06241 human MAP2 iso3 4133 P11137-3 MAP2 human Y67 454429 EHGSQGTySNTKENG X +FYN Fyn P06241 human calponin 3 54321 P37397 Cnn3 rat Y261 452163 SQKGMSVyGLGRQVY Calponin X +FYN Fyn P06241 human LKB1 20869 Q9WTK7 Stk11 mouse Y365 13258701 DIEDGIIytQDFTVP X X +FYN Fyn P06241 human DCC 25311 Q63155 Dcc rat Y1418 454409 TEDPASVyEQDDLSE Neogenin_C X +FYN Fyn P06241 human STAM2 10254 O75886 STAM2 human Y371 449670 LVNEAPVysVysKLH X +FYN Fyn P06241 human APP 351 P05067 APP human Y757 448202 SkMQQNGyENPtykF APP_amyloid X +FYN Fyn P06241 human Hic-5 7041 O43294 TGFB1I1 human Y60 450964 SGDKDHLystVCKPR Paxillin X +FYN Fyn P06241 human IFITM3 66141 Q9CQW9 Ifitm3 mouse Y27 482855 yERIkEEyEVAEMGA X +FYN Fyn P06241 human SLAM 6504 Q13291 SLAMF1 human Y281 447633 EKKsLtIyAQVQKPG X +FYN Fyn P06241 human Cortactin 2017 Q14247 CTTN human Y470 447703 AyATEAVyESAEAPG X +FYN Fyn P06241 human calponin 1 65204 Q08290 Cnn1 rat Y261 452161 SQRGMTVyGLPRQVY Calponin X +FYN Fyn P06241 human CENTG1 iso2 116986 Q99490-2 AGAP2 human Y682 467224 ESWIRAKyEQLLFLA ArfGap X X +FYN Fyn P06241 human GABRG2 14406 P22723 Gabrg2 mouse Y413 455818 ERDEEyGyECLDGKD Neur_chan_memb X +FYN Fyn P06241 human Lmr1 iso2 11302 Q80YE4-2 Aatk mouse Y46 4269100 AQTGPDVyVLPLTEV X X +FYN Fyn P06241 human CTNND1 12388 P30999 Ctnnd1 mouse Y228 449648 yPGGsDNyGsLsRVT X 2911 +FYN Fyn P06241 human BSG iso2 682 P35613-2 BSG human Y140 1868502601 PVTDWAWyKITDSED Ig_3 X X +FYN Fyn P06241 human SLAM 6504 Q13291 SLAMF1 human Y307 448264 QDPCTTIyVAATEPV X +FYN Fyn P06241 human NPHS1 54631 Q9QZS7 Nphs1 mouse Y1191 2299202 MAFPGHLyDEVERVY X X +FYN Fyn P06241 human FLOT1 10211 O75955 FLOT1 human Y160 462262 DIHDDQDyLHsLGkA Band_7 X +FYN Fyn P06241 human NPHS1 64563 Q9R044 Nphs1 rat Y1212 6377601 DEVRMDPyDLRWPEV X +FYN Fyn P06241 human Fyn 2534 P06241 FYN human Y28 447879 sLNQssGyRyGTDPT X +FYN Fyn P06241 human DCBLD2 131566 Q96PD2 DCBLD2 human Y569 473074 EGtyDLPyWDRAGWW X +FYN Fyn P06241 human STAM2 10254 O75886 STAM2 human Y291 474371 kSEPEPVyIDEDkMD X +FYN Fyn P06241 human PTPRJ 5795 Q12913 PTPRJ human Y1320 15228667 NtTAMtIyENLAPVT X +FYN Fyn P06241 human Abl 25 P00519 ABL1 human Y128 459259 SLEKHSWyHGPVSRN SH2 X +FYN Fyn P06241 human PTPRJ 5795 Q12913 PTPRJ human Y1311 473909 DSkVDLIyQNtTAMt X +FYN Fyn P06241 human NPHS1 64563 Q9R044 Nphs1 rat Y1171 6377603 PTLEEVLyHQGAEGE X +FYN Fyn P06241 human BSG iso2 682 P35613-2 BSG human Y183 38486780 MEADPGQyRCNGTSS Ig_3 X X +FYN Fyn P06241 human FLOT2 2319 Q14254 FLOT2 human Y163 475941 DVYDkVDyLSsLGkT Band_7 X +FYN Fyn P06241 human H3F3A 3020 P84243 H3-3A human S10 18545301 tkQTARkstGGkAPR Histone X X 9706; 3458 +FYN Fyn P06241 human NPHS1 64563 Q9R044 Nphs1 rat Y1228 469566 CEDPRGIyDQVAADM X +FYN Fyn P06241 human NPHS1 64563 Q9R044 Nphs1 rat Y1152 6377604 TAEVDPNyySMRDFS X +FYN Fyn P06241 human DAB1 100037307 A1Y2K0 DAB1 pig Y198 447629 EDVEDPVyQyIVFEA X +FYN Fyn P06241 human PXN iso2 5829 P49023-2 PXN human Y118 448604 VGEEEHVysFPNKQK Paxillin X 2541; 69363 +FYN Fyn P06241 human FCGR2B 2213 P31994 FCGR2B human Y292 448507 GAENTITysLLMHPD X +FYN Fyn P06241 human NMDAR2A 2903 Q12879 GRIN2A human Y1267 461052 PATGEQVyQQDWAQN NMDAR2_C X +FYN Fyn P06241 human LKB1 20869 Q9WTK7 Stk11 mouse Y261 13258700 PFEGDNIyKLFENIG Pkinase X X +FYN Fyn P06241 human RSK2 6197 P51812 RPS6KA3 human Y483 464202 IItLkDVyDDGKyVY Pkinase X +FYN Fyn P06241 human DCBLD2 131566 Q96PD2 DCBLD2 human Y655 478857 GyADLDPyNsPGQEV X +FYN Fyn P06241 human NPHS1 64563 Q9R044 Nphs1 rat Y1153 1317600 AEVDPNyySMRDFSP X +FYN Fyn P06241 human PPP2CA 5515 P67775 PPP2CA human Y307 448571 VTRRtPDyFl_____ X +FYN Fyn P06241 human Abl 25 P00519 ABL1 human Y226 450303 KRNKPtVyGVsPNyD X 2868; 2861 +FYN Fyn P06241 human SNCA 6622 P37840 SNCA human Y125 448279 VDPDNEAyEMPsEEG Synuclein X +FYN Fyn P06241 human SCN5A 6331 Q14524 SCN5A human Y1495 455660 TEEQKkyyNAMKKLG X X +FYN Fyn P06241 human Fyn 2534 P06241 FYN human Y39 447881 TDPTPQHyPSFGVTS X +FYN Fyn P06241 human SKAP55 8631 Q86WV1 SKAP1 human Y295 460296 TRRKGVDyASyyQGL X +FYN Fyn P06241 human PPP2CA 5515 P67775 PPP2CA human Y284 457325 ELDDTLkySFLQFDP X +FYN Fyn P06241 human NOX4 50507 Q9NPH5 NOX4 human Y566 57848101 LSNQNNSyGTRFEYN X +FYN Fyn P06241 human Fyn 2534 P06241 FYN human Y214 455043 KLDNGGyyITtRAQF SH2 X +FYN Fyn P06241 human Cortactin 2017 Q14247 CTTN human Y446 448776 GtEPEPVysMEAADy X +FYN Fyn P06241 human LKB1 20869 Q9WTK7 Stk11 mouse Y166 13258702 QLIDGLEyLHSQGIV Pkinase X +FYN Fyn P06241 human PLXNA2 5362 O75051 PLXNA2 human Y1677 1121331800 sKMVSEIyLTRLLAT Plexin_cytopl X +FYN Fyn P06241 human CD3E 916 P07766 CD3E human Y199 448917 RKGQRDLysGLNQRR ITAM X +FYN Fyn P06241 human Abl 25 P00519 ABL1 human Y115 450305 QGWVPsNyItPVNSL X +FYN Fyn P06241 human STAT3 6774 P40763 STAT3 human Y705 448192 DPGsAAPyLktKFIC X 4093; 9145; 4324; 9131; 9138; 4323; 4074; 4113; 48313; 20977; 25023; 8119; 52075; 52527; 73533; 61958; 73452; 16185; 74309 +FYN Fyn P06241 human KIRREL 170643 Q80W68 Kirrel1 mouse Y719 455014 SQLSyENyEKFNSHP X +FYN Fyn P06241 human CBL 867 P22681 CBL human Y774 448531 sENEDDGyDVPKPPV X 3555 +FYN Fyn P06241 human PLEKHG1 57480 Q9ULL1 PLEKHG1 human Y661 15502837 IDDIDHVyDNISYED X X +FYN Fyn P06241 human FCGR2A 2212 P12318 FCGR2A human Y288 449553 yEtADGGyMtLNPRA X +FYN Fyn P06241 human Abl 25 P00519 ABL1 human Y215 469589 GLITTLHyPAPKRNK X +FYN Fyn P06241 human Abl 25 P00519 ABL1 human Y70 462900 PNLFVALyDFVAsGD SH3_1 X 3098 +FYN Fyn P06241 human Fyn 2534 P06241 FYN human Y213 451536 RKLDNGGyyITtRAQ SH2 X +FYN Fyn P06241 human Nogo 57142 Q9NQC3 RTN4 human Y694 470039 LQETEAPyISIACDL X +FYN Fyn P06241 human DAB1 100037307 A1Y2K0 DAB1 pig Y200 447960 VEDPVyQyIVFEAGH X +FYN Fyn P06241 human DCBLD2 131566 Q96PD2 DCBLD2 human Y649 473121 EEGKEAGyADLDPyN X +FYN Fyn P06241 human CD133 8842 O43490 PROM1 human Y828 462569 RMDsEDVyDDVEtIP X +FYN Fyn P06241 human CLIC5 53405 Q9NZA1 CLIC5 human Y33 3081200 EENESPHyDDVHEYL X +FYN Fyn P06241 human CENTG1 iso2 116986 Q99490-2 AGAP2 human Y774 467225 QGRTALFyARQAGSQ Ank_2 X X +FYN Fyn P06241 human RSK2 6197 P51812 RPS6KA3 human Y707 448775 KGAMAAtysALNRNQ X +FYN Fyn P06241 human NPHS1 64563 Q9R044 Nphs1 rat Y1204 469565 PGAWGPLyDEVRMDP X +FYN Fyn P06241 human NMDAR2A 2903 Q12879 GRIN2A human Y943 461053 SDkGNLMysDNRSFQ NMDAR2_C X +FYN Fyn P06241 human IP3R1 3708 Q14643 ITPR1 human Y353 450970 NAQEKMVySLVSVPE MIR X X +FYN Fyn P06241 human PTPRT iso1 11122 O14522-1 PTPRT human Y915 11315001 GYGFKEEyEALPEGQ X +FYN Fyn P06241 human Fyn 2534 P06241 FYN human Y420 447882 RLIEDNEytARQGAk PK_Tyr_Ser-Thr X X 2101; 6943; 59548; 70926; 78740; 94361; 17320 +FYN Fyn P06241 human Tau iso8 4137 P10636-8 MAPT human Y18 454024 MEDHAGtyGLGDRKD X +FYN Fyn P06241 human PSD-95 1742 P78352 DLG4 human Y523 4093600 REDSVLSyETVTQME X X +FYN Fyn P06241 human CD300LB 124599 A8K4G0 CD300LB human Y188 975498 EPGEQPIyMNFSEPL X +FYN Fyn P06241 human DAB1 iso2 13131 P97318-2 Dab1 mouse Y185 447959 KQCEQAVyQTILEED X +FYN Fyn P06241 human SLAP-130 2533 O15117 FYB1 human Y571 454079 TTAVEIDyDsLkLKK X X +FYN Fyn P06241 human SKAP55 8631 Q86WV1 SKAP1 human Y298 460297 KGVDyASyyQGLWDC X +FYN Fyn P06241 human calponin 1 65204 Q08290 Cnn1 rat Y182 452162 sQQGMTAyGTRRHLY Calponin X +FYN Fyn P06241 human DAB1 iso2 13131 P97318-2 Dab1 mouse Y198 447629 EDVEDPVyQyIVFEA X +FYN Fyn P06241 human CTNND1 12388 P30999 Ctnnd1 mouse Y112 472275 PGQIVETyTEEDPEG X +FYN Fyn P06241 human NMDAR2A 2903 Q12879 GRIN2A human Y1325 458211 RLLEGNFyGSLFSVP NMDAR2_C X +FYN Fyn P06241 human SLAP-130 2533 O15117 FYB1 human Y771 449430 ADNDGEIyDDIAdGC hSH3 X +FYN Fyn P06241 human PLXNA2 5362 O75051 PLXNA2 human Y1605 474307 VPKQTSSyNIPASAs Plexin_cytopl X +FYN Fyn P06241 human cytohesin 1 19157 Q9QX11 Cyth1 mouse Y382 464074 AISRDPFyEMLAARK X +FYN Fyn P06241 human caveolin-1 857 Q03135 CAV1 human Y14 448422 VDsEGHLytVPIREQ X X 3251 +FYN Fyn P06241 human Bcr 613 P11274 BCR human Y177 447792 ADAEKPFyVNVEFHH X 3901 +FYN Fyn P06241 human DBNL 13169 Q62418 Dbnl mouse Y340 450090 QTEEEPTyEVPPEQD X +FYN Fyn P06241 human CD3E 916 P07766 CD3E human Y188 448918 PPVPNPDyEPIRKGQ ITAM X +FYN Fyn P06241 human GRB10 2887 Q13322 GRB10 human Y67 448348 NASLESLySACSMQS X X +FYN Fyn P06241 human SLAP-130 2533 O15117 FYB1 human Y559 15149800 GRTARGsyGyIKTTA SH3_2 X +FYN Fyn P06241 human KIRREL 310695 Q6X936 Kirrel1 rat Y637 463751 MKDPTNGyyNVRAHE X X +FYN Fyn P06241 human CTNNG 3728 P14923 JUP human Y133 456971 AIVHLINyQDDAELA X +FYN Fyn P06241 human NRF2 4780 Q16236 NFE2L2 human Y576 460703 RDEDGkPysPSEYSL X +FYN Fyn P06241 human PLXNA1 5361 Q9UIW2 PLXNA1 human Y1679 1121331801 sKMVSEIyLTRLLAT Plexin_cytopl X +FYN Fyn P06241 human MAP2 iso3 4133 P11137-3 MAP2 human Y50 2792500 RSANGFPyREDEEGA X +FYN Fyn P06241 human PLCG2 5336 P16885 PLCG2 human Y759 447941 LyDVsRMyVDPsEIN X 3874; 50535 +FYN Fyn P06241 human RSK2 6197 P51812 RPS6KA3 human Y529 464205 TITKTVEyLHAQGVV Pkinase X X +FYN Fyn P06241 human EFTU 281556 P49410 TUFM cow Y115 55372798 INAAHVEySTAARHY GTP_EFTU X +FYN Fyn P06241 human KIRREL 310695 Q6X936 Kirrel1 rat Y638 463752 KDPTNGyyNVRAHED X X +FYN Fyn P06241 human RSK2 6197 P51812 RPS6KA3 human Y580 3455194 GLLMtPCytANFVAP Pkinase X +FYN Fyn P06241 human Lmr1 iso2 11302 Q80YE4-2 Aatk mouse Y25 4269101 ENAEGDEyVADFSEQ X X +FYN Fyn P06241 human CD133 8842 O43490 PROM1 human Y852 462570 GYHkDHVyGIHNPVM X +FYN Fyn P06241 human HER2 2064 P04626 ERBB2 human Y877 448694 LDIDEtEyHADGGkV PK_Tyr_Ser-Thr X 2241 +FYN Fyn P06241 human DLC1 50768 Q9R0Z9 Dlc1 mouse Y702 1869008601 SAEDNVNyEGQSAYD RhoGAP X +FYN Fyn P06241 human IFITM3 66141 Q9CQW9 Ifitm3 mouse Y20 463584 SGGQPPNyERIkEEy X +FYN Fyn P06241 human PECAM-1 5175 P16284 PECAM1 human Y713 448760 KKDtEtVysEVRKAV X +FYN Fyn P06241 human DCBLD2 131566 Q96PD2 DCBLD2 human Y621 454599 LQADsAEyAQPLVGG X +FYN Fyn P06241 human TRIO 310192 F1M0Z1 Trio rat Y2685 27425000 LLNPNYIyDVPPEFV X +FYN Fyn P06241 human Abl 25 P00519 ABL1 human Y139 456712 VSRNAAEyLLsSGIN SH2 X +FYN Fyn P06241 human Cortactin 2017 Q14247 CTTN human Y486 447704 yPAEDStyDEYENDL X +FYN Fyn P06241 human DCBLD2 131566 Q96PD2 DCBLD2 human Y732 455063 CssAQAQyDtPKAGk X +FYN Fyn P06241 human CRMP-4 25418 Q62952 Dpysl3 rat Y32 464893 VNDDQSFyADIYMED X +FYN Fyn P06241 human PRC1 9055 O43663 PRC1 human Y464 474466 QTETEMLyGsAPRtP MAP65_ASE1 X +FYN Fyn P06241 human KIRREL 170643 Q80W68 Kirrel1 mouse Y716 455015 DTTSQLSyENyEKFN X +FYN Fyn P06241 human DCBLD2 131566 Q96PD2 DCBLD2 human Y677 475112 LPITGPEyAtPIIMD X +FYN Fyn P06241 human EFTU 281556 P49410 TUFM cow Y246 474427 LLDAVDTyIPVPTRD GTP_EFTU X +FYN Fyn P06241 human Cortactin 2017 Q14247 CTTN human Y421 447702 rLPssPVyEDAAsFK X 4569 +FYN Fyn P06241 human Fyn 2534 P06241 FYN human Y30 447880 NQssGyRyGTDPTPQ X +FYN Fyn P06241 human SKAP2 54353 Q3UND0 Skap2 mouse Y260 449668 QPIDDEIyEELPEEE X X +FYN Fyn P06241 human RSK2 6197 P51812 RPS6KA3 human Y470 478835 EIEILLRyGQHPNII Pkinase X +FYN Fyn P06241 human STAM2 10254 O75886 STAM2 human Y374 449671 EAPVysVysKLHPPA X +FYN Fyn P06241 human DLC1 50768 Q9R0Z9 Dlc1 mouse Y452 1869008602 NVPGSILySSSGELA X +FYN Fyn P06241 human SLAP-130 2533 O15117 FYB1 human Y595 452094 IEDDQEVyDDVAEQD X X +FYN Fyn P06241 human DCBLD2 131566 Q96PD2 DCBLD2 human S618 23097815 TTVLQADsAEyAQPL X +FYN Fyn P06241 human KIRREL 170643 Q80W68 Kirrel1 mouse Y638 463752 kDPTNGyyNVRAHED X X +FYN Fyn P06241 human AMPKA2 5563 P54646 PRKAA2 human Y436 58109404 EWKVVNAyHLRVRRK AdenylateSensor X X +FYN Fyn P06241 human PGD 5226 P52209 PGD human Y481 465221 GtVSSssyNA_____ X X +FYN Fyn P06241 human P38A 1432 Q16539 MAPK14 human Y323 455799 DEPVADPyDQsFESR X +FYN Fyn P06241 human IREM-1 146722 Q8TDQ1 CD300LF human Y263 474549 AEDQEPTyCNMGHLS X +FYN Fyn P06241 human DCBLD2 131566 Q96PD2 DCBLD2 human Y666 478858 GQEVyHAyAEPLPIT X +FYN Fyn P06241 human Ig-beta 15985 P15530 Cd79b mouse Y195 459286 GMEEDHTyEGLNIDQ ITAM X +FYN Fyn P06241 human SCN9A 6335 Q15858 SCN9A human Y1482 1121331802 TEEQKkyyNAMKKLG X +FYN Fyn P06241 human CTNNB1 12387 Q02248 Ctnnb1 mouse Y142 449044 AVVNLINyQDDAELA X +FYN Fyn P06241 human SLAM 6504 Q13291 SLAMF1 human Y327 447634 ETNSITVyASVTLPE X +FYN Fyn P06241 human CBL 867 P22681 CBL human Y700 448529 EGEEDtEyMtPssRP X 8869 +FYN Fyn P06241 human DAB1 iso1 ABR15760 DAB1 pig Y185 447959 KQCEQAVyQVPTSQK X +FYN Fyn P06241 human DAB1 100037307 A1Y2K0 DAB1 pig Y232 447961 SQKKEGVyDVPKSQP X +FYN Fyn P06241 human Abl 25 P00519 ABL1 human Y172 460505 LRyEGRVyHyRINTA SH2 X +FYN Fyn P06241 human CD5 921 P06127 CD5 human Y487 447775 DNssDsDyDLHGAQR X +FYN Fyn P06241 human COX-2 5743 P35354 PTGS2 human Y446 484179 DQSRQMkyQSFNEYR An_peroxidase X +FYN Fyn P06241 human DAB1 iso2 13131 P97318-2 Dab1 mouse Y232 447961 SQKKEGVyDVPKSQP X +FYN Fyn P06241 human GUCY1B1 54195 O54865 Gucy1b1 mouse Y192 469612 ESKEEDFyEDLDRFE X +FYN Fyn P06241 human Siglec-10 89790 Q96LC7 SIGLEC10 human Y667 450087 ESQEELHyATLNFPG X +FYN Fyn P06241 human RSK2 6197 P51812 RPS6KA3 human Y644 473285 KFSLSGGyWNSVSDT Pkinase X +FYN Fyn P06241 human CRMP-2 25416 P47942 Dpysl2 rat Y32 463168 VNDDQSFyADIYMED X X +FYN Fyn P06241 human PBK 55872 Q96KB5 PBK human Y272 54400800 DFDDEAYyAALGTRP Pkinase X X +FYN Fyn P06241 human TIGIT 201633 Q495A1 TIGIT human Y225 27266400 DCAELHDyFNVLSYR X +FYN Fyn P06241 human NMDAR2A 2903 Q12879 GRIN2A human Y1187 476853 NNDQyKLySKHFTLK NMDAR2_C X +FYN Fyn P06241 human GABRG2 14406 P22723 Gabrg2 mouse Y411 455817 LQERDEEyGyECLDG Neur_chan_memb X +FYN Fyn P06241 human PLEKHG1 57480 Q9ULL1 PLEKHG1 human Y742 1876191900 QAVEENIyDTIGLPD X X +FYN Fyn P06241 human DCBLD2 131566 Q96PD2 DCBLD2 human Y663 3974132 NsPGQEVyHAyAEPL X +FYN Fyn P06241 human PTPRT iso1 11122 O14522-1 PTPRT human Y1030 458414 WPDDTEVyGDIKVTL Y_phosphatase X +FYN Fyn P06241 human SCN9A 6335 Q15858 SCN9A human Y1481 1121331803 MTEEQKkyyNAMKKL X +FYN Fyn P06241 human SLAP-130 2533 O15117 FYB1 human Y755 464285 CRNEEGkyGyVLRSy hSH3 X +FYN Fyn P06241 human NPHS1 54631 Q9QZS7 Nphs1 mouse Y1208 469565 PGVWGPLyDEVQMDP X X +FYN Fyn P06241 human FAK 25614 O35346 Ptk2 rat Y928 447966 DRSNDKVyENVTGLV Focal_AT X 3284 +FYN Fyn P06241 human DBNL 13169 Q62418 Dbnl mouse Y350 450091 PPEQDTLyEEPPLVQ X +FYN Fyn P06241 human NPHS1 64563 Q9R044 Nphs1 rat Y1194 6377600 HDEVERAyGPPGAWG X +FYN Fyn P06241 human Fyn 2534 P06241 FYN human Y185 465282 sETtkGAysLsIRDW SH2 X +FYN Fyn P06241 human Cortactin 2017 Q14247 CTTN human Y453 449517 ysMEAADyREASSQQ X +FYN Fyn P06241 human Abl 25 P00519 ABL1 human Y185 450304 TAsDGKLyVsSESRF SH2 X 3009 +FYN Fyn P06241 human CBL 867 P22681 CBL human Y731 448530 QQIDSCTyEAMyNIQ X X 3554 +FYN Fyn P06241 human DAB1 100037307 A1Y2K0 DAB1 pig Y185 447959 KQCEQAVyQTILEED X +FYN Fyn P06241 human RSK2 6197 P51812 RPS6KA3 human Y488 464203 DVyDDGKyVYVVTEL Pkinase X +FYN Fyn P06241 human hnRNP P2 2521 P35637 FUS human Y526 50318713 QDrrErPy_______ X +FYN Fyn P06241 human CTNND1 12388 P30999 Ctnnd1 mouse Y96 449495 QDHNHLLystIPRMQ X +FYN Fyn P06241 human SHP-2 5781 Q06124 PTPN11 human Y542 448492 sKRkGHEytNIKysL X 3751; 94740; 15543; 64117 +FYN Fyn P06241 human MAP2 4133 P11137 MAP2 human Y67 454429 EHGsQGtySNTKENG X +FYN Fyn P06241 human PLXNA1 5361 Q9UIW2 PLXNA1 human Y1608 458728 VPKQTSAyNISNSSt Plexin_cytopl X +FYN Fyn P06241 human DNAM-1 10666 Q15762 CD226 human Y322 454845 DDTREDIyVNyPTFs X +FYN Fyn P06241 human KIRREL 170643 Q80W68 Kirrel1 mouse Y637 463751 MkDPTNGyyNVRAHE X X +FYN Fyn P06241 human NMDAR2B 14812 Q01097 Grin2b mouse Y1070 461055 IsTHtVTyGNIEGNA NMDAR2_C X 4209 +FYN Fyn P06241 human LKB1 20869 Q9WTK7 Stk11 mouse Y156 13258703 PVCQAHGyFRQLIDG Pkinase X +FYN Fyn P06241 human LKB1 20869 Q9WTK7 Stk11 mouse Y60 448152 DLLGEGSyGKVKEVL Pkinase X +FYN Fyn P06241 human CTNNG 3728 P14923 JUP human Y550 456972 AAGtQQPytDGVRME X +FYN Fyn P06241 human ADD2 119 P35612 ADD2 human Y489 449419 PNQFVPLyTDPQEVL X +FYN Fyn P06241 human SLAP-130 2533 O15117 FYB1 human Y757 464286 NEEGkyGyVLRSyLA hSH3 X +FYN Fyn P06241 human NPHS1 64563 Q9R044 Nphs1 rat Y1127 6377602 EDRIRNEyEESQWTG X +FYN Fyn P06241 human IREM-1 146722 Q8TDQ1 CD300LF human Y236 474548 VDQVEVEyVTMASLP SIT X +FYN Fyn P06241 human SLAP-130 2533 O15117 FYB1 human Y780 459246 DIAdGCIyDND____ hSH3 X +FYN Fyn P06241 human IKKG 8517 Q9Y6K9 IKBKG human Y374 473650 PLPPAPAyLssPLAL X +FYN Fyn P06241 human PKACA 5566 P17612 PRKACA human Y70 1269647501 HKETGNHyAMKILDK Pkinase X +Camk1 CAMK1A Q91YS8 mouse PPM1H 319468 Q3UYC0 Ppm1h mouse S210 3215799 RTLTRAAsLrGGVGA X X +TTK TTK P33981 human USP16 10600 Q9Y5T5 USP16 human S415 3217536 VEDEDQDsEEEKDND UCH X +TTK TTK P33981 human HSP90A 3320 P07900 HSP90AA1 human T115 13256102 GtIAksGtkAFMEAL HATPase_c X +TTK TTK P33981 human TTK 7272 P33981 TTK human S742 4145509 QQIINQIsKLHAIID Pkinase X +TTK TTK P33981 human BLM 641 P54132 BLM human S1296 452326 TsPAEDssPGISLSs X +TTK TTK P33981 human TTK 7272 P33981 TTK human T46 41389704 NKISADttDNsGTVN X +TTK TTK P33981 human USP16 10600 Q9Y5T5 USP16 human T554 3217539 EVLtssPtRNLNGAY UCH X +TTK TTK P33981 human Abl 25 P00519 ABL1 human T735 450291 DTEWRSVtLPRDLQS X X 2864 +TTK TTK P33981 human TTK 7272 P33981 TTK human T288 6370307 sPDCDVktDDsVVPC X X +TTK TTK P33981 human TTK 7272 P33981 TTK human T33 2846502 kFkNEDLtDELsLNK X X +TTK TTK P33981 human HSPA9B 3313 P38646 HSPA9 human T62 483967 VVGIDLGtTNsCVAV HSP70 X +TTK TTK P33981 human TTK 7272 P33981 TTK human S321 3189826 SkPsGNDsCELRNLk X +TTK TTK P33981 human TTK 7272 P33981 TTK human T12 13194901 DLsGRELtIDsIMNk X X +TTK TTK P33981 human MAD1L1 8379 Q9Y6D9 MAD1L1 human S22 5024704 RsLNNFIsQRVEGGs X +TTK TTK P33981 human ARHGEF17 9828 Q96PE2 ARHGEF17 human T1007 54363501 APsLEDVtKQYMLNL X +TTK TTK P33981 human MAD1L1 8379 Q9Y6D9 MAD1L1 human S610 334535801 ELKKQVEsAELkNQR MAD X +TTK TTK P33981 human TTK 7272 P33981 TTK human T371 1737600 LLAkLEEtkEyQEPE X +TTK TTK P33981 human TTK 7272 P33981 TTK human T849 4145517 HNSsSsktFEkkRGK X +TTK TTK P33981 human MAD1L1 8379 Q9Y6D9 MAD1L1 human S62 334535803 AEQIRSksHLIQVER MAD X +TTK TTK P33981 human ARHGEF17 9828 Q96PE2 ARHGEF17 human T944 54363500 DEGsQDQtGsLsRAR X +TTK TTK P33981 human TTK 7272 P33981 TTK human T795 4145512 HPYVQIQtHPVNQMA X +TTK TTK P33981 human MAP4 4134 P27816 MAP4 human S928 468166 SRLAtNtsAPDLkNV Tubulin-binding X X +TTK TTK P33981 human Borealin 55143 Q53HL2 CDCA8 human T230 4203200 DskEIFLtVPVGGGE Borealin X +TTK TTK P33981 human BUB1B 701 O60566 BUB1B human S670 3207630 TLsIkkLsPIIEDsR X +TTK TTK P33981 human TTK 7272 P33981 TTK human T686 487541 VkDSQVGtVNYMPPE Pkinase X X +TTK TTK P33981 human TTK 7272 P33981 TTK human S821 467281 GQLVGLNsPNsILkA X +TTK TTK P33981 human TTK 7272 P33981 TTK human T676 487540 NQMQPDttsVVkDSQ Pkinase X X +TTK TTK P33981 human NCAPH2 29781 Q6IBW4 NCAPH2 human S492 459636 FVQEtELsQRIRDWE CNDH2_C X X +TTK TTK P33981 human ARHGEF17 9828 Q96PE2 ARHGEF17 human T751 54363502 AATSEEPtGFSVDSN X +TTK TTK P33981 human USP16 10600 Q9Y5T5 USP16 human S552 449274 DLEVLtssPtRNLNG UCH X +TTK TTK P33981 human BLM 641 P54132 BLM human S1290 467080 QKYSEWTsPAEDssP X +TTK TTK P33981 human TTK 7272 P33981 TTK human S847 4145515 ESHNSsSsktFEkkR X +TTK TTK P33981 human MAD1L1 8379 Q9Y6D9 MAD1L1 human T8 41286654 MEDLGENtMVLstLR X +TTK TTK P33981 human TTK 7272 P33981 TTK human S7 4272730 _MEsEDLsGRELtID X +TTK TTK P33981 human Borealin 55143 Q53HL2 CDCA8 human T94 4203201 AtADLDItEINkLtA X +TTK TTK P33981 human TTK 7272 P33981 TTK human S362 13194902 TLKNktEssLLAkLE X +TTK TTK P33981 human TTK 7272 P33981 TTK human T45 1880463702 LNKISADttDNsGTV X +TTK TTK P33981 human BUB1B 701 O60566 BUB1B human S1043 483373 WkVGkLtsPGALLFQ X +TTK TTK P33981 human MAD1L1 8379 Q9Y6D9 MAD1L1 human S598 18911590 AAASLPsskEVAELK MAD X +TTK TTK P33981 human BLM 641 P54132 BLM human S144 467079 KKLEFSssPDSLSTI BLM_N X +TTK TTK P33981 human TTK 7272 P33981 TTK human S49 1880463704 SADttDNsGTVNQIM X +TTK TTK P33981 human TTK 7272 P33981 TTK human T805 4145510 VNQMAkGttEEMkyV X +TTK TTK P33981 human BUB1B 701 O60566 BUB1B human S435 3207627 REAELLtsAEkRAEM X +TTK TTK P33981 human Borealin 55143 Q53HL2 CDCA8 human T169 4203202 KRssRANtVtPAVGR Borealin X +TTK TTK P33981 human TTK 7272 P33981 TTK human S80 2846503 EkNSVPLsDALLNkL X +TTK TTK P33981 human MAP4 4134 P27816 MAP4 human T927 10422252 LSRLAtNtsAPDLkN Tubulin-binding X X +TTK TTK P33981 human Borealin 55143 Q53HL2 CDCA8 human T88 4203203 QALEEAAtADLDItE X +TTK TTK P33981 human TTK 7272 P33981 TTK human S824 3189832 VGLNsPNsILkAAkT X +TTK TTK P33981 human TTK 7272 P33981 TTK human T564 4145511 LEEADNQtLDSYRNE Pkinase X +TTK TTK P33981 human HSPA9B 3313 P38646 HSPA9 human S65 483968 IDLGtTNsCVAVMEG HSP70 X +TTK TTK P33981 human BUB1B 701 O60566 BUB1B human S543 4049929 LsEkKNksPPADPPR X +TTK TTK P33981 human TTK 7272 P33981 TTK human S37 2846500 EDLtDELsLNKISAD X X +TTK TTK P33981 human SLC4A4 8671 Q9Y6R1 SLC4A4 human S12 3951822 AVLDRGAsFLKHVCD X +TTK TTK P33981 human TTK 7272 P33981 TTK human T806 4145514 NQMAkGttEEMkyVL X +TTK TTK P33981 human Chk2 11200 O96017 CHEK2 human T68 447491 SsLEtVstQELYsIP X 2197; 2661; 28130; 12812; 82263; 64180; 59068 +TTK TTK P33981 human Borealin 55143 Q53HL2 CDCA8 human S238 9721503 VPVGGGEsLRLLAsD Borealin X +TTK TTK P33981 human TTK 7272 P33981 TTK human T675 487539 ANQMQPDttsVVkDS Pkinase X X +TTK TTK P33981 human TTK 7272 P33981 TTK human S363 1737601 LKNktEssLLAkLEE X X +TTK TTK P33981 human MAD1L1 8379 Q9Y6D9 MAD1L1 human T716 334535800 LELFSRQtVA_____ MAD X X +TTK TTK P33981 human MAD1L1 8379 Q9Y6D9 MAD1L1 human T323 334535802 SWERLDQtMGLSIRT MAD X +TTK TTK P33981 human TTK 7272 P33981 TTK human S845 4145516 GGESHNSsSsktFEk X +TTK TTK P33981 human TTK 7272 P33981 TTK human T360 1737602 sITLKNktEssLLAk X X +TTK TTK P33981 human TTK 7272 P33981 TTK human S582 4145513 LNkLQQHsDkIIRLY Pkinase X +TTK TTK P33981 human TTK 7272 P33981 TTK human S436 950200 VFSVskQsPPIsTSk X +TTK TTK P33981 human TTK 7272 P33981 TTK human Y811 459314 GttEEMkyVLGQLVG X +TTK TTK P33981 human RMI2 116028 Q96E14 RMI2 human S112 29606701 MGVVQACsPEPCLQA RMI2 X +TTK TTK P33981 human TTK 7272 P33981 TTK human S15 13194900 GRELtIDsIMNkVRD X X +TTK TTK P33981 human MAD1L1 8379 Q9Y6D9 MAD1L1 human T624 334535804 RLkEVFQtkIQEFRK MAD X +TTK TTK P33981 human TTK 7272 P33981 TTK human S677 6311911 QMQPDttsVVkDSQV Pkinase X X +GRK1 GRK1 Q15835 human Rhodopsin 509933 P02699 RHO cow S334 448677 PLGDDEAsttVsKtE X +GRK1 GRK1 Q15835 human Rhodopsin 509933 P02699 RHO cow T340 448681 AsttVsKtEtsQVAP X +GRK1 GRK1 Q15835 human Rhodopsin 509933 P02699 RHO cow T342 452181 ttVsKtEtsQVAPA_ X +GRK1 GRK1 Q15835 human GPR120 iso1 338557 Q5NUL3-1 FFAR4 human S366 31014808 GAILtDtsVKRNDLs X +GRK1 GRK1 Q15835 human occludin 18260 Q61146 Ocln mouse S507 1976701 KQLKSKLsHIKRMVG Occludin_ELL X X +GRK1 GRK1 Q15835 human Claudin-5 12741 O54942 Cldn5 mouse T207 454390 YSAPRRPtANGDyDk X X +GRK1 GRK1 Q15835 human Rhodopsin 509933 P02699 RHO cow S343 448680 tVsKtEtsQVAPA__ X +GRK1 GRK1 Q15835 human occludin 18260 Q61146 Ocln mouse T382 1976700 tPSKRAPtKGKAGKG X X +GRK1 GRK1 Q15835 human KOR-1 4986 P41145 OPRK1 human S358 1975303 RMERQSTsRVRNTVQ X +GRK1 GRK1 Q15835 human Rhodopsin 509933 P02699 RHO cow S338 448679 DEAsttVsKtEtsQV X +GRK1 GRK1 Q15835 human GPR120 iso1 338557 Q5NUL3-1 FFAR4 human T363 31014807 PEKGAILtDtsVKRN X +GRK1 GRK1 Q15835 human GPR120 iso1 338557 Q5NUL3-1 FFAR4 human S373 31014806 sVKRNDLsIIsG___ X +CSNK1A1L CK1A2 Q8N752 human NFAT5 10725 O94916 NFAT5 human S158 2715403 LLDNsRMsCQDEGCG X +PRKCA PKCA P17252 human eNOS 4846 P29474 NOS3 human T495 447885 TGITRKKtFKEVANA X 9574 +PRKCA PKCA P17252 human TACSTD2 4070 P09758 TACSTD2 human S303 451171 VITNRRKsGKYKKVE X X +PRKCA PKCA P17252 human JPH2 57158 Q9BR39 JPH2 human S165 4779179 PLRTsLssLRsEHsN X +PRKCA PKCA P17252 human TOP1 7150 P11387 TOP1 human S21 2721301 ADFRLNDsHKHKDKH X +PRKCA PKCA P17252 human CYP2E1 1571 P05181 CYP2E1 human S247 23097372 AEVKEyVsERVkEHH p450 X +PRKCA PKCA P17252 human MYBPC1 iso2 109272 G0YZM8 Mybpc1 mouse S204 4738635 IRSAFKRsGEGQEDA X +PRKCA PKCA P17252 human p40phox 4689 Q15080 NCF4 human S315 448265 RQARGLPsQKRLFPW PB1 X X +PRKCA PKCA P17252 human ANXA1 301 P04083 ANXA1 human S28 452053 yVQtVksskGGPGsA X +PRKCA PKCA P17252 human AKAP12 83425 Q5QD51 Akap12 rat S507 469987 SPLKKLFsSsGLKKL X +PRKCA PKCA P17252 human CK1D 64462 Q06486 Csnk1d rat S393 53356806 LTGRQDtsRMstsQI X +PRKCA PKCA P17252 human MARCKS 613548 P12624 MARCKS cow S162 447787 KRFsFKKsFKLsGFs MARCKS X 11992 +PRKCA PKCA P17252 human PTP1B 5770 P18031 PTPN1 human S378 448669 RSRVVGGsLrGAQAA X +PRKCA PKCA P17252 human PLCG1 5335 P19174 PLCG1 human S1248 448665 HGrAREGsFEsRyQQ X X 4510; 13349; 8713 +PRKCA PKCA P17252 human FLNC 68794 Q8VHX6 Flnc mouse S2625 15403523 sSSsRGAsySSIPKF X +PRKCA PKCA P17252 human Tau iso8 4137 P10636-8 MAPT human S352 487459 DFKDrVQskIGsLDN Tubulin-binding X +PRKCA PKCA P17252 human PPAR-alpha 25747 P37230 Ppara rat T129 457548 CKGFFRRtIRLKLAY zf-C4 X +PRKCA PKCA P17252 human CENTA1 11033 O75689 ADAP1 human T276 11380901 GFRkRWFtMDDRRLM PH X +PRKCA PKCA P17252 human SERT 6532 P31645 SLC6A4 human T603 31014805 RLIITPGtFKERIIK X +PRKCA PKCA P17252 human PACSIN2 23970 Q9WVE8 Pacsin2 mouse S313 4786393 ADLNRtLsRREKKKA X X +PRKCA PKCA P17252 human ITGB2 3689 P05107 ITGB2 human S745 448532 FEkEKLksQWNNDNP Integrin_b_cyt X +PRKCA PKCA P17252 human G-alpha(z) 2781 P19086 GNAZ human S16 451242 EKEAARRsRRIDRHL G-alpha X X +PRKCA PKCA P17252 human PCDHGA3 93711 Q91XY5 Pcdhga3 mouse S922 41590812 GNGNKKKsGKKEKK_ Cadherin_tail X +PRKCA PKCA P17252 human C5aR 728 P21730 C5AR1 human S314 450055 FQGRLRKsLPsLLRN X +PRKCA PKCA P17252 human CDC42EP4 23580 Q9H3Q1 CDC42EP4 human S18 3212334 sVHskRRsRADLtAE X X +PRKCA PKCA P17252 human ADCY6 25289 Q03343 Adcy6 rat T931 455530 HAQQVEStARLDFLW X +PRKCA PKCA P17252 human RhoGDI alpha 396 P52565 ARHGDIA human S34 467490 ykPPAQKsIQEIQEL Rho_GDI X +PRKCA PKCA P17252 human CK1D 1453 P48730 CSNK1D human T174 1871153001 YRENkNLtGtARYAs Pkinase X +PRKCA PKCA P17252 human Ku70 2547 P12956 XRCC6 human S77 1875071706 VYISKIIssDRDLLA Ku_N X X +PRKCA PKCA P17252 human CK1D 1453 P48730 CSNK1D human S181 1868926301 tGtARYAsINTHLGI Pkinase X X +PRKCA PKCA P17252 human NHERF 9368 O14745 NHERF1 human S340 455753 RAHQKRssKRAPQMD EBP50_C X X +PRKCA PKCA P17252 human PKCE 18754 P16054 Prkce mouse S368 2085101 NNIRKALsFDNRGEE X +PRKCA PKCA P17252 human TACE 6868 P78536 ADAM17 human T735 449804 kPFPAPQtPGRLQPA X +PRKCA PKCA P17252 human CK1D 64462 Q06486 Csnk1d rat S328 3190837 PATRGLPstAsGRLR X +PRKCA PKCA P17252 human RRAD 6236 P55042 RRAD human S257 457395 QIRLRRDsKEANARR X +PRKCA PKCA P17252 human SRF 6722 P11831 SRF human S162 460665 LRRYtTFsKRkTGIM SRF-TF X X +PRKCA PKCA P17252 human MT1 24567 P02803 Mt1 rat S32 7965104 KCTSCKKsCCSCCPV Metallothio X +PRKCA PKCA P17252 human VTN 7448 P04004 VTN human S393 452177 sRGRNQNsRRPsRAT X +PRKCA PKCA P17252 human ATP5C 509 P36542 ATP5F1C human S146 467518 GILYRtHsDQFLVAF ATP-synt X +PRKCA PKCA P17252 human EGLN2 112398 Q96KS0 EGLN2 human S226 4213803 LRDGQLVsQRAIPPR X +PRKCA PKCA P17252 human PPAR-alpha 5465 Q07869 PPARA human S230 2902207 VKARVILsGKASNNP X +PRKCA PKCA P17252 human TNNI3 511094 P08057 TNNI3 cow S44 450690 AKKKSKIsAsRKLQL X +PRKCA PKCA P17252 human Ezrin 7430 P15311 EZR human T567 448104 QGRDkyKtLRQIRQG ERM_C X 3141; 3726; 32600 +PRKCA PKCA P17252 human CACNA1C 100101555 P15381 CACB rabbit S1928 455278 ASLGRRAsFHLECLK CAC1F_C X X +PRKCA PKCA P17252 human p21Cip1 1026 P38936 CDKN1A human S146 447836 GRkRRQtsMTDFyHs X +PRKCA PKCA P17252 human SRF 6722 P11831 SRF human T159 449631 DNkLRRYtTFsKRkT SRF-TF X X +PRKCA PKCA P17252 human CACNA1C 12288 Q01815 Cacna1c mouse S1644 480102 QGLVGkPsQRNALsL X +PRKCA PKCA P17252 human CDC42EP4 23580 Q9H3Q1 CDC42EP4 human S80 35524901 SskRsLLsRKFRGSK PBD X X +PRKCA PKCA P17252 human GMF-beta 2764 P60983 GMFB human S72 451487 QPRFIVYsYkYQHDD Cofilin_ADF X +PRKCA PKCA P17252 human CELF1 10658 Q92879 CELF1 human S179 29668003 QtMEGCssPMVVkFA X +PRKCA PKCA P17252 human Kv11.1 3757 Q12809 KCNH2 human S890 3893409 RQRKRKLsFRRRtDK X +PRKCA PKCA P17252 human GRF-1 2909 Q9NRY4 ARHGAP35 human S1236 7159801 PKPKPRPsITKATWE RhoGAP_pG1_pG2 X +PRKCA PKCA P17252 human sialophorin 6693 P16150 SPN human S351 451340 tFFGRRKsRQGsLAM X +PRKCA PKCA P17252 human CK1D 64462 Q06486 Csnk1d rat S370 483997 MERERKVsMRLHRGA X +PRKCA PKCA P17252 human TRPV1 83810 O35433 Trpv1 rat S820 456218 QLKHYTGsLkPEDAE X +PRKCA PKCA P17252 human TRPV5 56302 Q9NQA5 TRPV5 human S299 470108 FLELVVSsDKREARQ X +PRKCA PKCA P17252 human mGluR7 81672 P35400 Grm7 rat S862 2846504 NVQKRKRsFKAVVTA X +PRKCA PKCA P17252 human NMDAR1 24408 P35439 Grin1 rat S889 449107 AITSTLAssFKRRRs X +PRKCA PKCA P17252 human FLOT1 10211 O75955 FLOT1 human S315 18750500 QAEAEAAsVRMRGEA X X +PRKCA PKCA P17252 human IGFBP1 3484 P08833 IGFBP1 human S144 451659 NFHLMAPsEEDHSIL X +PRKCA PKCA P17252 human KCNJ8 25472 Q63664 Kcnj8 rat S391 1458602 NsMRRNNsMRRSNsI X +PRKCA PKCA P17252 human FLNC 2318 Q14315 FLNC human S2624 15403523 sSssRGssyssIPkF X +PRKCA PKCA P17252 human EIF6 3692 P56537 EIF6 human S235 450271 QPstIAtsMRDsLID X X +PRKCA PKCA P17252 human SHP-2 5781 Q06124 PTPN11 human S591 469623 GLMQQQksFR_____ X +PRKCA PKCA P17252 human TNNT2 286816 P13789 TNNT2 cow S195 451755 KAQtERKsGKRQtER Troponin X +PRKCA PKCA P17252 human CELF1 10658 Q92879 CELF1 human S28 3347300 GQVPrtWsEkDLREL RRM_1 X +PRKCA PKCA P17252 human MYH9 4627 P35579 MYH9 human S1916 451181 AMNREVssLkNkLRr Myosin_tail_1 X +PRKCA PKCA P17252 human GJA1 24392 P08050 Gja1 rat S364 450183 AIVDQRPssRAssRA X +PRKCA PKCA P17252 human hnRNP A1 29578 P04256 Hnrnpa1 rat S197 2874413 SSsQRGRsGsGNFGG X +PRKCA PKCA P17252 human KCNE3 10008 Q9Y6H6 KCNE3 human S82 460569 LILGYTRsRKVDKRS ISK_Channel X +PRKCA PKCA P17252 human CTPS 1503 P17812 CTPS1 human T455 473570 MRLGKRRtLFQTkNs GATase X X +PRKCA PKCA P17252 human TRPV5 Q9XSM3 Trpv5 rabbit S654 470109 YVEAFKCsDKEDGQE X +PRKCA PKCA P17252 human H1R 3269 P35367 HRH1 human S398 450937 WKRLRsHsRQyVSGL 7tm_1 X +PRKCA PKCA P17252 human CYP2E1 1571 P05181 CYP2E1 human T69 23940005 QRFGPVFtLYVGsQR p450 X +PRKCA PKCA P17252 human MARCKS 396473 P16527 MARCKS chicken S124 447786 KKKKKRFsFKKsFKL MARCKS X 11992 +PRKCA PKCA P17252 human ANXA2 302 P07355 ANXA2 human S26 450879 tPPsAyGsVkAytNF X X +PRKCA PKCA P17252 human rabphilin 3A 171039 P47709 Rph3a rat S234 455904 GPPTRRAsEARMSTT X +PRKCA PKCA P17252 human CYP3A4 1576 P08684 CYP3A4 human T264 5938005 KEsRLEDtQKHRVDF p450 X +PRKCA PKCA P17252 human PXR 8856 O75469 NR1I2 human T408 9730704 RSINAQHtQRLLRIQ Hormone_recep X +PRKCA PKCA P17252 human RSC1A1 Q29106 RSC1A1 pig S370 10433802 LHELLVIsSKPALEN X +PRKCA PKCA P17252 human hnRNP A1 29578 P04256 Hnrnpa1 rat S95 476057 RAVSREDsQRPGAHL X +PRKCA PKCA P17252 human SLC6A2 6530 P23975 SLC6A2 human T258 465613 SLWKGVKtsGKVVWI SNF X +PRKCA PKCA P17252 human TNNI3 511094 P08057 TNNI3 cow S25 448424 PPVRRRssANYRAYA Troponin-I_N X +PRKCA PKCA P17252 human CK1D 1453 P48730 CSNK1D human S53 1868926300 HPQLHIEskIYkMMQ Pkinase X X +PRKCA PKCA P17252 human syndecan-4 24771 P34901 Sdc4 rat S183 449863 MKKKDEGsYDLGKKP Syndecan X +PRKCA PKCA P17252 human uPA 5328 P00749 PLAU human S158 451052 CADGKKPsSPPEELK X +PRKCA PKCA P17252 human p14ARF 1029 Q8N726 CDKN2A human T8 27523604 MVRRFLVtLRIRRAC P19Arf_N X +PRKCA PKCA P17252 human Claudin-4 12740 O35054 Cldn4 mouse S195 4199301 RSNDKPYsAkYsAAR X +PRKCA PKCA P17252 human CYSLTR1 10800 Q9Y271 CYSLTR1 human S315 11143521 tFRKHsLssVTYVPR X +PRKCA PKCA P17252 human HDAC4 9759 P56524 HDAC4 human S632 448490 RPLSRAQssPAsAtF X 3424 +PRKCA PKCA P17252 human IL2RA 3559 P01589 IL2RA human S268 455369 WQRRQRKsRRtI___ X X +PRKCA PKCA P17252 human SERT 6532 P31645 SLC6A4 human S149 31014804 yHRNGCIsIWRKICP SNF X +PRKCA PKCA P17252 human CFTR 1080 P13569 CFTR human S737 449981 EPLERRLsLVPDSEQ CFTR_R X +PRKCA PKCA P17252 human PPP2R5A 5525 Q15172 PPP2R5A human S41 3196904 RQKRsQGssQFRsQG X +PRKCA PKCA P17252 human TRPV4 63873 Q9EPK8 Trpv4 mouse S824 4777181 LRRDRWssVVPRVVE X +PRKCA PKCA P17252 human CFTR 1080 P13569 CFTR human T682 2907505 APVSWTEtKKQsFKQ CFTR_R X +PRKCA PKCA P17252 human RRAD 6236 P55042 RRAD human S273 457396 AGTRRREsLGKKAKR X +PRKCA PKCA P17252 human ITGB4 3691 P16144 ITGB4 human S1356 451653 ysDDVLRsPSGsQRP X +PRKCA PKCA P17252 human Kv-beta2 8514 Q13303 KCNAB2 human S266 451000 IPPYSRAsLkGYQWL Aldo_ket_red X +PRKCA PKCA P17252 human MMP2 4313 P08253 MMP2 human T377 479860 DGKMWCAttANYDDD Peptidase_M10; fn2 X +PRKCA PKCA P17252 human NMDAR2A 2903 Q12879 GRIN2A human S929 485949 ADFIQRGsLIMDMVS NMDAR2_C X +PRKCA PKCA P17252 human AQP1 358 P29972 AQP1 human T157 482806 VLCVLATtDRRRRDL MIP X X +PRKCA PKCA P17252 human CTNND1 12388 P30999 Ctnnd1 mouse S879 450459 LIDRNQKsDKKPDRE X +PRKCA PKCA P17252 human coronin 1A 12721 O89053 Coro1a mouse S426 31905585 PEPsGtPssDTVsRL Trimer_CC X +PRKCA PKCA P17252 human ITGB2 3689 P05107 ITGB2 human T758 448533 NPLFksAtttVMNPk Integrin_b_cyt X +PRKCA PKCA P17252 human DAB2 79128 O88797 Dab2 rat S24 451211 QAAPKAPsKKEKKKG X +PRKCA PKCA P17252 human CYP2E1 1571 P05181 CYP2E1 human S56 23940003 ELKNIPKsFtRLAQR p450 X +PRKCA PKCA P17252 human FLNC 2318 Q14315 FLNC human S2623 27449343 KsSssRGssyssIPk X +PRKCA PKCA P17252 human KCNMA1 282573 Q28204 KCNMA1 cow S695 456596 DEQPSTLsPKKKQRN X +PRKCA PKCA P17252 human PKCE 5581 Q02156 PRKCE human S316 2085100 tPDKITNsGQRRkKL X +PRKCA PKCA P17252 human uPA 5328 P00749 PLAU human S323 451053 TGFGKENsTDYLYPE Trypsin X +PRKCA PKCA P17252 human LRP1 4035 Q07954 LRP1 human S4523 7103863 GsRHsLAsTDEkREL X X +PRKCA PKCA P17252 human GLT1 20511 P43006 Slc1a2 mouse S562 486052 nGksADCsVEEEPWk X +PRKCA PKCA P17252 human PDE3A 5139 Q14432 PDE3A human S293 471416 FkRRRRsssVVsAEM X +PRKCA PKCA P17252 human ADD2 119 P35612 ADD2 human S726 449803 KKKEKVEs_______ X +PRKCA PKCA P17252 human ULK1 8408 O75385 ULK1 human S423 1880900310 GRAGPFSsSRCGAsV X +PRKCA PKCA P17252 human SLC29A1 63959 Q9JIM1 Slc29a1 mouse S281 21326706 PPtNRNQsIKAILKs Nucleoside_tran X +PRKCA PKCA P17252 human RRAD 6236 P55042 RRAD human S214 457394 LVRSREVsVDEGRAC Ras X +PRKCA PKCA P17252 human TRPV6 55503 Q9H1D0 TRPV6 human T742 11381600 WERLRQGtLRRDLRG X +PRKCA PKCA P17252 human DMBT1 12945 Q60997 Dmbt1 mouse S2082 13201903 IDRGQPPsTKL____ X +PRKCA PKCA P17252 human ROMK 3758 P48048 KCNJ1 human T193 2813503 KKRAKtItFSKNAVI IRK_C X +PRKCA PKCA P17252 human VTN 7448 P04004 VTN human S397 452178 NQNsRRPsRATWLSL X +PRKCA PKCA P17252 human ADRA1D 146 P25100 ADRA1D human S334 1424270003 HtFRssLsVRLLKFS 7tm_1 X +PRKCA PKCA P17252 human ITGB1 3688 P05556 ITGB1 human S785 452040 GENPIyksAVttVVN Integrin_b_cyt X +PRKCA PKCA P17252 human EGLN2 112398 Q96KS0 EGLN2 human S132 4213804 GGDAPsPsKRPWARQ X +PRKCA PKCA P17252 human calponin 1 396911 Q08092 CNN1 pig S175 450890 MGTNKFAsQQGMTAY Calponin X +PRKCA PKCA P17252 human ITGB4 iso2 3691 P16144-2 ITGB4 human S1424 465821 tLTRDyNsLTRSEHS X +PRKCA PKCA P17252 human CYP3A4 1576 P08684 CYP3A4 human S131 22553305 EEWkRLRsLLsPtFT p450 X +PRKCA PKCA P17252 human Sin1 79109 Q9BPZ7 MAPKAP1 human S128 3830292 kSLFEKKsLKEKPPI SIN1 X +PRKCA PKCA P17252 human Akt1 207 P31749 AKT1 human S473 447855 RPHFPQFsysAsGtA Pkinase_C X X 9271; 3787; 4060; 4051; 5102; 4058; 2336; 2337; 4075; 4070; 5012; 4071; 92982; 5315; 9563; 9018; 12694; 52240; 11962; 15116; 88106; 26580; 68035; 31957; 23430; 20235 +PRKCA PKCA P17252 human PPP1R14A 94274 Q96A00 PPP1R14A human T38 449098 QkRHARVtVkYDRRE PP1_inhibitor X +PRKCA PKCA P17252 human RKIP 29542 P31044 Pebp1 rat S153 448755 RGkFkVEsFRKKYHL PBP X +PRKCA PKCA P17252 human p47phox 653361 P14598 NCF1 human S320 451726 QRsRKRLsQDAYRRN NECFESHC X +PRKCA PKCA P17252 human GluR4 29629 P19493 Gria4 rat S862 448810 TRNKARLsITGSVGE X +PRKCA PKCA P17252 human p53 7157 P04637 TP53 human S376 447570 LkskkGQstsRHkkL X +PRKCA PKCA P17252 human MOR-1 18390 P42866 Oprm1 mouse S363 447783 STIEQQNsARIRQNt X X +PRKCA PKCA P17252 human NOXA1 10811 Q86UR1 NOXA1 human S172 990300 DQVQRRGsLPPRQVP X X +PRKCA PKCA P17252 human DAT 24898 P23977 Slc6a3 rat S4 454428 ____MsKsKCsVGPM X +PRKCA PKCA P17252 human 4E-BP1 116636 Q62622 Eif4ebp1 rat S64 447527 FLMECRNsPVAKtPP eIF_4EBP X 9451; 9456 +PRKCA PKCA P17252 human SCN2A 24766 P04775 Scn2a rat S610 451195 DNDSRRDsLFVPHRH Na_trans_cytopl X +PRKCA PKCA P17252 human CD4 920 P01730 CD4 human S440 469618 sQIkRLLsEKKTCQC Tcell_CD4_C X +PRKCA PKCA P17252 human RALB 5899 P11234 RALB human S198 16827200 KSSKNKKsFKERCCL X X +PRKCA PKCA P17252 human RALBP1 10928 Q15311 RALBP1 human S118 487528 VFKKPsFsKKKEKDF X +PRKCA PKCA P17252 human TNNI3 7137 P19429 TNNI3 human S23 448423 PAPIRRRssNyRAyA Troponin-I_N X 4004 +PRKCA PKCA P17252 human TUBA1C 84790 Q9BQE3 TUBA1C human S165 8046500 sVDyGkkskLEFSIy Tubulin X +PRKCA PKCA P17252 human EphA2 1969 P29317 EPHA2 human S892 3189622 ADFDPRVsIRLPsts X X +PRKCA PKCA P17252 human RhoGDI beta 397 P52566 ARHGDIB human S31 4933709 ykPPPQksLkELQEM Rho_GDI X X +PRKCA PKCA P17252 human Caldesmon 373965 P12957 CALD1 chicken S615 2873302 RAEFLNKsAQKSGMK Caldesmon X +PRKCA PKCA P17252 human SLC18A2 6571 Q05940 SLC18A2 human S15 30332702 LVRWLQEsRRsRKLI X +PRKCA PKCA P17252 human AQP4 361 P55087 AQP4 human S180 467301 TIFASCDsKRTDVTG MIP X +PRKCA PKCA P17252 human PTP-PEST 5782 Q05209 PTPN12 human S435 451312 KKLERNLsFEIKKVP X X +PRKCA PKCA P17252 human CYP3A4 1576 P08684 CYP3A4 human S100 22553303 VLVKECYsVFtNRRP p450 X +PRKCA PKCA P17252 human EGFR 1956 P00533 EGFR human T678 448053 RHIVRKRtLRRLLQE X X 14343 +PRKCA PKCA P17252 human ADCY6 25289 Q03343 Adcy6 rat S10 450817 LPVARSGsGRSSMsW X +PRKCA PKCA P17252 human GRK7 131890 Q8WTQ7 GRK7 human S36 456355 ELQRRRRsLALPGLQ X +PRKCA PKCA P17252 human NHERF E2RGF3 SLC9A3R1 dog S349 455753 RAHQKRssKRAPQMD EBP50_C X X +PRKCA PKCA P17252 human TfR 7037 P02786 TFRC human S24 451671 PLsytRFsLARQVDG X +PRKCA PKCA P17252 human INSR 3643 P06213 INSR human S1062 451562 AVkTVNEsAsLRERI PK_Tyr_Ser-Thr X +PRKCA PKCA P17252 human Kv3.4 3749 Q03721 KCNC4 human S21 451078 KsGNKPPsKTCLKEE Potassium_chann X +PRKCA PKCA P17252 human Vinculin 396422 P12003 VCL chicken S1114 451252 VREAEAAsIKIRTDA X +PRKCA PKCA P17252 human PLM 58971 O08589 Fxyd1 rat T89 455220 SsIRRLstRRR____ X +PRKCA PKCA P17252 human TRPV1 83810 O35433 Trpv1 rat T704 487542 WKLQRAItILDTEKS X +PRKCA PKCA P17252 human ADCY2 81636 P26769 Adcy2 rat S490 25795203 DGAKMRAsVRMTRYL X +PRKCA PKCA P17252 human AQP2 359 P41181 AQP2 human S256 449854 REVRRRQsVELHsPQ X +PRKCA PKCA P17252 human AMPKA1 5562 Q13131 PRKAA1 human S496 450431 AtPQRsGsVsNyRSC AdenylateSensor X 4185; 4184; 2537 +PRKCA PKCA P17252 human myelin P0 539462 P10522 MPZ cow S210 458930 HKTAKDAsKRGRQTP Myelin-PO_C X +PRKCA PKCA P17252 human AID 11628 Q9WVE0 Aicda mouse S3 20660600 _____MDsLLMKQKK X +PRKCA PKCA P17252 human CACNA1C 100101555 P15381 CACB rabbit S533 453091 RIsKSKFsRYWRRWN X +PRKCA PKCA P17252 human MARCKS 396473 P16527 MARCKS chicken S132 466360 FKKsFKLsGFsFKKN MARCKS X 8722 +PRKCA PKCA P17252 human SHP-2 5781 Q06124 PTPN11 human S576 469622 CAEMREDsARVyENV X +PRKCA PKCA P17252 human PKG1 5592 Q13976 PRKG1 human T59 1870119330 THIGPRTtRAQGIsA X +PRKCA PKCA P17252 human SLC6A2 6530 P23975 SLC6A2 human S259 465614 LWKGVKtsGKVVWIT SNF X +PRKCA PKCA P17252 human NOX5 iso4 79400 Q96PH1-4 NOX5 human T494 472625 KRLsRSVtMRKsQRS FAD_binding_8 X X +PRKCA PKCA P17252 human CaR 846 P41180 CASR human S875 4782110 TIEEVRCsTAAHAFK X +PRKCA PKCA P17252 human mGluR5 iso2 24418 P31424-2 Grm5 rat S901 4213805 QHLWQRLsVHINKKE X X +PRKCA PKCA P17252 human NMDAR1 24408 P35439 Grin1 rat S897 448256 sFKRRRssKDtSTGG X +PRKCA PKCA P17252 human N-CoR1 9611 O75376 NCOR1 human S70 3828921 QQLRRRPsLLsEFHP X +PRKCA PKCA P17252 human EPB41 iso4 2035 P11171-4 EPB41 human S312 455112 QAQTRQAsALIDRPA FA X +PRKCA PKCA P17252 human ADRA1D 146 P25100 ADRA1D human S332 1424270006 KGHtFRssLsVRLLK 7tm_1 X +PRKCA PKCA P17252 human Cortactin 60465 A6HYF4 Cttn rat T145 41425400 GFEYQGktEKHASQK HS1_rep X +PRKCA PKCA P17252 human TNNT2 21956 P50752 Tnnt2 mouse T207 449038 YIQkQAQtERKsGKR Troponin X +PRKCA PKCA P17252 human CACNA1C 100101555 P15381 CACB rabbit S1843 9808101 EAAWKLssKRCHSQE CAC1F_C X +PRKCA PKCA P17252 human p21Cip1 1026 P38936 CDKN1A human S153 456134 sMTDFyHskRrLIFS X X +PRKCA PKCA P17252 human PLM 476487 P56513 FXYD1 dog S83 451424 EEGTFRSsIRRLstR X X +PRKCA PKCA P17252 human NR2C1 22025 Q505F1 Nr2c1 mouse S185 457682 IEVSREKsSNCAAST X +PRKCA PKCA P17252 human CYP2E1 1571 P05181 CYP2E1 human S424 23940008 ENGkFkYsDYFkPFs p450 X +PRKCA PKCA P17252 human SLC1A1 25550 P51907 Slc1a1 rat T5 13204400 ___MGKPtSSGCDWR X +PRKCA PKCA P17252 human GluR1 2890 P42261 GRIA1 human S836 467226 cYKsRsEsKRMKGFC X +PRKCA PKCA P17252 human RIGI 23586 O95786 RIGI human T170 12613700 DkENWPktLkLALEk CARD_2 X X +PRKCA PKCA P17252 human PPAR-alpha 5465 Q07869 PPARA human S179 457549 RFGRMPRsEKAKLkA X +PRKCA PKCA P17252 human TNNI3 7137 P19429 TNNI3 human T143 451483 RGKFKRPtLRrVrIs Troponin X +PRKCA PKCA P17252 human GJA1 24392 P08050 Gja1 rat S372 465460 sRAssRAssRPRPDD X +PRKCA PKCA P17252 human mGluR7 108073 Q68ED2 Grm7 mouse S862 2846504 NVQKRKRsFKAVVTA X +PRKCA PKCA P17252 human RSC1A1 6248 Q92681 RSC1A1 human S366 10433802 LHELLVVsSkPASEN X +PRKCA PKCA P17252 human CENTA1 11033 O75689 ADAP1 human S87 11380900 AARARFEsKVPSFYY ArfGap X +PRKCA PKCA P17252 human PDE5A 281972 Q28156 PDE5A cow S92 448178 GTPTRKIsASEFDRP X +PRKCA PKCA P17252 human NHERF 9368 O14745 NHERF1 human S339 455752 ERAHQKRssKRAPQM EBP50_C X X +PRKCA PKCA P17252 human L-plastin 3936 P13796 LCP1 human S5 450852 ___MARGsVsDEEMM X +PRKCA PKCA P17252 human DAT 24898 P23977 Slc6a3 rat S13 451138 CsVGPMssVVAPAKE X +PRKCA PKCA P17252 human ARHGEF1 9138 Q92888 ARHGEF1 human S240 4936516 TkSGDKKsGRNFFRK X +PRKCA PKCA P17252 human TNNI3 29248 P23693 Tnni3 rat S23 448423 PAPVRRRssANYRAY Troponin-I_N X 4004 +PRKCA PKCA P17252 human neurogranin 4900 Q92686 NRGN human S36 455913 AAAKIQAsFrGHMAR IQ X +PRKCA PKCA P17252 human IRS1 16367 P35569 Irs1 mouse S318 451399 MVGGKPGsFRVRASs X 5610 +PRKCA PKCA P17252 human CYSLTR1 58861 Q99JA4 Cysltr1 mouse T151 27717317 VQNINLVtQKKARFV 7tm_1 X +PRKCA PKCA P17252 human Tau iso8 4137 P10636-8 MAPT human S324 449328 kVtskCGsLGNIHHk Tubulin-binding X +PRKCA PKCA P17252 human Vimentin 7431 P08670 VIM human S8 471087 MStrsVssssyrrMF Filament_head X +PRKCA PKCA P17252 human GSK3A 606496 Q2NL51 Gsk3a mouse S21 448584 sGRARtssFAEPGGG X 9337; 9316; 9331; 9327; 8452; 8566 +PRKCA PKCA P17252 human UGT1A3 54659 P35503 UGT1A3 human S43 34357665 IDGSHWLsMREVLRE UDPGT X +PRKCA PKCA P17252 human Mena iso4 13800 Q03173-4 Enah mouse S236 451465 WERERRMsNAAPSSD X +PRKCA PKCA P17252 human NMDAR2B 2904 Q13224 GRIN2B human S1323 455808 ALAPRSVsLKDKGRF NMDAR2_C X +PRKCA PKCA P17252 human Akt1 24185 P47196 Akt1 rat S473 447855 RPHFPQFsYSASGTA Pkinase_C X 9271; 3787; 4060; 4051; 5102; 4058; 2336; 2337; 4075; 4070; 5012; 4071; 92982; 5315; 9563; 9018; 12694; 52240; 11962; 15116; 88106; 26580; 68035; 31957; 23430; 20235 +PRKCA PKCA P17252 human Titin 22138 A2ASS6 Ttn mouse S12884 4693667 RKkLRPGsGGEKPPD X +PRKCA PKCA P17252 human Lck 3932 P06239 LCK human S42 447819 tLLIRNGsEVRDPLV X +PRKCA PKCA P17252 human Vimentin 7431 P08670 VIM human S9 455450 StrsVssssyrrMFG Filament_head X +PRKCA PKCA P17252 human NCAM-L1 3897 P32004 L1CAM human T1172 4702537 ARPMkDEtFGEyRSL Bravo_FIGEY X +PRKCA PKCA P17252 human Vinculin 396422 P12003 VCL chicken S1102 451251 NAQNLMQsVKETVRE X +PRKCA PKCA P17252 human PLM 476487 P56513 FXYD1 dog S88 451425 RSsIRRLstRRR___ X X +PRKCA PKCA P17252 human RRAD 6236 P55042 RRAD human S290 457397 GRIVARNsRKMAFRA X +PRKCA PKCA P17252 human Caldesmon 373965 P12957 CALD1 chicken S602 457430 CFsPKGSsLKIEERA Caldesmon X +PRKCA PKCA P17252 human PITPNC1 26207 Q9UKF7 PITPNC1 human S274 454503 SVRsAPSsAPstPLs X +PRKCA PKCA P17252 human PR 5241 P06401 PGR human S400 449842 GAEAsARsPRSYLVA Prog_receptor X +PRKCA PKCA P17252 human STXBP1 25558 P61765 Stxbp1 rat S306 448743 VSQEVTRsLkDFSSs Sec1 X +PRKCA PKCA P17252 human PPP1R1A 58977 P19103 Ppp1r1a rat S65 469609 PLLKSTLsMsPRQRK DARPP-32 X X +PRKCA PKCA P17252 human CYP2E1 1571 P05181 CYP2E1 human T387 23940012 GYLIPKGtVVVPTLD p450 X +PRKCA PKCA P17252 human GluR1 50592 P19490 Gria1 rat S849 448565 FCLIPQQsINEAIrT X 75574 +PRKCA PKCA P17252 human MARCKS 4082 P29966 MARCKS human S163 447787 KRFsFkKsFkLsGFs MARCKS X X 2741; 11992 +PRKCA PKCA P17252 human TRPM4 54795 Q8TD43 TRPM4 human S1152 12559512 sERLKRTsQKVDLAL X +PRKCA PKCA P17252 human CELF1 10658 Q92879 CELF1 human T173 29668007 kAMHQAQtMEGCssP RRM_1 X +PRKCA PKCA P17252 human FBXW7 55294 Q969H0 FBXW7 human S10 17337000 QELLSVGsKRRRTGG X +PRKCA PKCA P17252 human JAK2 3717 O60674 JAK2 human S518 56527201 VFRTNGVsDVPtsPT X +PRKCA PKCA P17252 human SLC22A1 24904 Q63089 Slc22a1 rat T550 455614 TIYLQVQtGKSSST_ X +PRKCA PKCA P17252 human Cofilin-1 1072 P23528 CFL1 human S23 9218412 NDMkVRksstPEEVk Cofilin_ADF X X +PRKCA PKCA P17252 human PKCE 5581 Q02156 PRKCE human S234 479975 EtPDQVGsQRFSVNM X +PRKCA PKCA P17252 human CYSLTR1 10800 Q9Y271 CYSLTR1 human S313 11143517 LstFRKHsLssVTYV X +PRKCA PKCA P17252 human SLC38A3 252919 Q9JHZ9 Slc38a3 rat S52 19001700 KGFLQQSsSKEPHFT X +PRKCA PKCA P17252 human IGFBP1 3484 P08833 IGFBP1 human S126 451658 GsPEsPEstEITEEE X +PRKCA PKCA P17252 human GLT1 29482 P31596 Slc1a2 rat S563 486052 NGksADCsVEEEPWk X +PRKCA PKCA P17252 human CELF1 10658 Q92879 CELF1 human S302 3347301 TSSGSsPsSSSSNSV X +PRKCA PKCA P17252 human MBP 618684 P02687 MBP cow S109 451768 QGKGrGLsLSRFsWG Myelin_MBP X +PRKCA PKCA P17252 human PIP5K1B 18719 P70181 Pip5k1b mouse S413 27461455 PSKKRCNsIAALKAT X X +PRKCA PKCA P17252 human GPR120 iso1 338557 Q5NUL3-1 FFAR4 human S366 31014808 GAILtDtsVKRNDLs X +PRKCA PKCA P17252 human ROMK 3758 P48048 KCNJ1 human S4 2813507 ____MNAsSRNVFDT X +PRKCA PKCA P17252 human IGFBP1 3484 P08833 IGFBP1 human S123 4668105 AEAGsPEsPEstEIT X +PRKCA PKCA P17252 human CaR 846 P41180 CASR human T888 449862 FKVAARAtLRRsNVs X X +PRKCA PKCA P17252 human DOCK8 81704 Q8NF50 DOCK8 human S2082 3929310 VEsQKRDsFHRSsFR X +PRKCA PKCA P17252 human NFkB-p65 5970 Q04206 RELA human S536 447800 sGDEDFSsIADMDFS X 4887; 3036; 3031; 4886; 3033; 4025; 5733; 13346; 76778; 31553; 80477; 73992; 87672; 83962 +PRKCA PKCA P17252 human NOXO1 iso3 124056 Q8NFA2-3 NOXO1 human T341 28758706 AIQSRCCtVTRRALE X X +PRKCA PKCA P17252 human CHAT iso3 1103 P28329-3 CHAT human S440 449057 VPTYESAsIRRFQEG Carn_acyltransf X +PRKCA PKCA P17252 human BAP37 11331 Q99623 PHB2 human S39 1868188300 VAyGVREsVFTVEGG X X +PRKCA PKCA P17252 human FBXW7 55294 Q969H0 FBXW7 human S18 17337001 KRRRTGGsLRGNPSs X X +PRKCA PKCA P17252 human PLD2 5338 O14939 PLD2 human T252 456498 LLYMCLEtGAISFVQ X +PRKCA PKCA P17252 human GJA1 24392 P08050 Gja1 rat S365 459207 IVDQRPssRAssRAs X +PRKCA PKCA P17252 human MBP 618684 P02687 MBP cow S150 487420 HDAQGtLsKIFKLGG Myelin_MBP X +PRKCA PKCA P17252 human MARCKS 613548 P12624 MARCKS cow S169 451837 sFKLsGFsFKKNKKE MARCKS X 8722 +PRKCA PKCA P17252 human ADCY6 25289 Q03343 Adcy6 rat S674 455529 EDLEKKYsRKVDPRF Adcy_cons_dom X +PRKCA PKCA P17252 human TXA2-R 6915 P21731 TBXA2R human S331 470029 sTRPRsLsLQPQLtQ X +PRKCA PKCA P17252 human ANXA5 iso2 AAB24204 ANXA5 cow T22 2358301 DERADAEtLRKAMKG Annexin X +PRKCA PKCA P17252 human NMDAR2B 2904 Q13224 GRIN2B human S1415 1874095504 QPtVAGAsKARPDFR NMDAR2_C X +PRKCA PKCA P17252 human TRPV1 83810 O35433 Trpv1 rat T144 456216 QRSKKRLtDSEFKDP Ank_2 X +PRKCA PKCA P17252 human GluR6 2898 Q13002 GRIK2 human S868 478417 MVEELRMsLKcQRRL X +PRKCA PKCA P17252 human GSK3B 56637 Q9WV60 Gsk3b mouse S9 449111 SGRPRttsFAEsCKP X X 9336; 9331; 9327; 9323; 9322; 9325; 5558; 8566; 79774; 8466; 25462; 14026; 14332; 14310; 14630 +PRKCA PKCA P17252 human TAUT 404000 Q00589 SLC6A6 dog S322 450688 YNKYKYNsYRDCMLL SNF X X +PRKCA PKCA P17252 human SLC6A12 404013 P27799 SLC6A12 dog T40 33673901 VKDRGQWtNKMEFVL SNF X +PRKCA PKCA P17252 human eNOS 287024 P29473 NOS3 cow T497 447885 AGITRKktFKEVANA X +PRKCA PKCA P17252 human LRP1 4035 Q07954 LRP1 human T4460 12526700 GFQHQRMtNGAMNVE X X +PRKCA PKCA P17252 human TNNI3 511094 P08057 TNNI3 cow S46 450691 KKSKIsAsRKLQLKT X +PRKCA PKCA P17252 human hnRNP A1 29578 P04256 Hnrnpa1 rat S223 2874412 FGrGGNFsGrGGFGG X +PRKCA PKCA P17252 human SSTR2 P30680 Sstr2 rat S343 7652105 EDGERsDsKQDKsRL X +PRKCA PKCA P17252 human NR1H4 iso2 9971 Q96RI1-2 NR1H4 human S154 4245800 CKGFFRRsITKNAVY zf-C4 X X +PRKCA PKCA P17252 human C5aR 728 P21730 C5AR1 human S332 448822 EEsVVREsKsFTRsT X +PRKCA PKCA P17252 human NLGN4X 57502 Q8N0W4 NLGN4X human T707 40245512 KDKRRHEtHRRPSPQ X X +PRKCA PKCA P17252 human RhoGDI alpha 396 P52565 ARHGDIA human S96 486318 DLtGDLEsFKkQsFV Rho_GDI X X +PRKCA PKCA P17252 human HSP27 3315 P04792 HSPB1 human S15 448401 FsLLrGPsWDPFrDW X 2404 +PRKCA PKCA P17252 human ARRB1 408 P49407 ARRB1 human S163 31894300 EkIHKRNsVRLVIRK Arrestin_N X X +PRKCA PKCA P17252 human DAT 24898 P23977 Slc6a3 rat S7 451136 _MsKsKCsVGPMssV X +PRKCA PKCA P17252 human CYSLTR1 58861 Q99JA4 Cysltr1 mouse T323 11143513 NFRRRLStFRKHSLs X +PRKCA PKCA P17252 human TNNI3 7137 P19429 TNNI3 human S44 450691 KKskIsAsRKLQLKt X +PRKCA PKCA P17252 human LRP1 4035 Q07954 LRP1 human S4517 4769100 LyMGGHGsRHsLAsT X X +PRKCA PKCA P17252 human myelin P0 539462 P10522 MPZ cow S233 458933 SRSTKAAsEKKTKGL Myelin-PO_C X +PRKCA PKCA P17252 human TXA2-R 6915 P21731 TBXA2R human S324 3061802 RRLQPRLsTRPRsLs X +PRKCA PKCA P17252 human CHAT iso3 1103 P28329-3 CHAT human S347 454036 LKHVTQssRKLIRAD Carn_acyltransf X +PRKCA PKCA P17252 human MARCKS 396473 P16527 MARCKS chicken S135 451837 sFKLsGFsFKKNKKE MARCKS X 8722 +PRKCA PKCA P17252 human CYP3A4 1576 P08684 CYP3A4 human S116 8084159 GPVGFMksAIsIAED p450 X +PRKCA PKCA P17252 human TXA2-R 6915 P21731 TBXA2R human S329 450989 RLsTRPRsLsLQPQL X +PRKCA PKCA P17252 human DTNB 1838 O60941 DTNB human T212 27100603 MLNMFLDtMMADPPP EF-hand_3 X +PRKCA PKCA P17252 human CK1D 1453 P48730 CSNK1D human S298 1871153003 NMLKFGAsRAADDAE X +PRKCA PKCA P17252 human coronin 1A 11151 P31146 CORO1A human T412 3995219 RVNRGLDtGRRRAAP Trimer_CC X X +PRKCA PKCA P17252 human CHAT iso3 1103 P28329-3 CHAT human T255 454038 TVLVKDStNRDSLDM Carn_acyltransf X +PRKCA PKCA P17252 human p47phox 653361 P14598 NCF1 human S370 451730 PAVPPRPsADLILNR p47_phox_C X +PRKCA PKCA P17252 human ASIC3 286920 O35240 Asic3 rat T40 12518704 IFGPGGLtLRRGLWA TM; ASC X +PRKCA PKCA P17252 human NPHS1 4868 O60500 NPHS1 human T1125 18507017 QWtGERDtQSSTVST X X +PRKCA PKCA P17252 human GluR5 29559 P22756 Grik1 rat S923 457626 QKKLKKKsRTKGKsS X +PRKCA PKCA P17252 human PFKFB3 5209 Q16875 PFKFB3 human S461 448801 NPLMRRNsVtPLAsP X +PRKCA PKCA P17252 human LSD1 99982 Q6ZQ88 Kdm1a mouse S112 3828907 TPEGRRTsRRKRAKV X X +PRKCA PKCA P17252 human SCN2A 24766 P04775 Scn2a rat S576 2999206 PrRNsRAsLFNFKGR Na_trans_cytopl X +PRKCA PKCA P17252 human RRAD 6236 P55042 RRAD human S299 457398 KMAFRAKsKsCHDLS X +PRKCA PKCA P17252 human eIF2-gamma 1968 P41091 EIF2S3 human T66 21514202 kAISGVHtVRFkNEL GTP_EFTU X +PRKCA PKCA P17252 human CYP3A4 1576 P08684 CYP3A4 human T284 22553307 DSQNSkEtESHKALS p450 X +PRKCA PKCA P17252 human ITGB2 3689 P05107 ITGB2 human T760 450185 LFksAtttVMNPkFA Integrin_b_cyt X +PRKCA PKCA P17252 human MKLN1 27418 O89050 Mkln1 mouse T515 474505 MVPMTGFtQRATIDP X +PRKCA PKCA P17252 human CACNA1B 257648 Q02294 Cacna1b rat S774 455280 SVWEQRAsQLRLQNL X +PRKCA PKCA P17252 human KCNMA1 3778 Q12791 KCNMA1 human S1200 9805700 SHSsQSSsKKSSsVH X +PRKCA PKCA P17252 human ITGB4 3691 P16144 ITGB4 human S1364 451655 PSGsQRPsVSDDTGC X +PRKCA PKCA P17252 human Titin 22138 A2ASS6 Ttn mouse S12742 10029600 KEEVVLksVLRKKPE X +PRKCA PKCA P17252 human TRPV1 7442 Q8NER1 TRPV1 human S502 450016 YFLQRRPsMKTLFVD Ion_trans X +PRKCA PKCA P17252 human mGluR5 24418 P31424 Grm5 rat S839 455778 VRSAFTTstVVRMHV X +PRKCA PKCA P17252 human TNNT2 286816 P13789 TNNT2 cow T200 451556 RKsGKRQtEREKKKK Troponin X +PRKCA PKCA P17252 human PTPN22 26191 Q9Y2R2 PTPN22 human S751 5963554 kSFtRSKsLKILRNM X X +PRKCA PKCA P17252 human Tau iso8 4137 P10636-8 MAPT human S293 449327 NVQskCGsKDNIkHV Tubulin-binding X +PRKCA PKCA P17252 human CYP2E1 1571 P05181 CYP2E1 human S431 23940014 sDYFkPFstGkRVCA p450 X +PRKCA PKCA P17252 human GluR6 14806 P39087 Grik2 mouse S846 11496000 VGEFLYKsKKNAQLE X X +PRKCA PKCA P17252 human MBP 618684 P02687 MBP cow S131 451769 FGYGGRAsDYKSAHK Myelin_MBP X +PRKCA PKCA P17252 human PPP1R14A 397610 O18734 PPP1R14A pig T38 449098 QKRHARVtVKYDRRE PP1_inhibitor X +PRKCA PKCA P17252 human TRPM2 iso3 7226 O94759-3 TRPM2 human S39 30312508 NLRRSNSsLFKSWRL X +PRKCA PKCA P17252 human CELF1 10658 Q92879 CELF1 human S300 29668005 VLTSSGSsPsSSSSN X +PRKCA PKCA P17252 human SH2-B-beta 25970 Q9NRF2 SH2B1 human S165 21336501 VGRsVRGsVRGILQW X +PRKCA PKCA P17252 human TXA2-R 6915 P21731 TBXA2R human T337 451395 LsLQPQLtQRSGLQ_ X +PRKCA PKCA P17252 human PPP1R1A 5502 Q13522 PPP1R1A human T75 471085 PRQRKKMtRItPTMK DARPP-32 X +PRKCA PKCA P17252 human TNNI3 511094 P08057 TNNI3 cow S79 451839 GEKGRALsTRCQPLE Troponin X +PRKCA PKCA P17252 human TNNI3 7137 P19429 TNNI3 human S42 450690 AKKKskIsAsRKLQL X +PRKCA PKCA P17252 human Bcl-11B 64919 Q9C0K0 BCL11B human S2 55578701 ______MsRRKQGNP X +PRKCA PKCA P17252 human SLC29A1 63959 Q9JIM1 Slc29a1 mouse S288 21326707 sIKAILKsICVPALS Nucleoside_tran X +PRKCA PKCA P17252 human Kit 3815 P10721 KIT human S746 450036 RRsVRIGsyIERDVT PK_Tyr_Ser-Thr X +PRKCA PKCA P17252 human THOP1 64517 P24155 Thop1 rat S644 448213 VGMDYRTsILRPGGS Peptidase_M3 X +PRKCA PKCA P17252 human MYBPC1 iso2 109272 G0YZM8 Mybpc1 mouse T84 21560211 NANSQLstLFVEKPQ I-set X +PRKCA PKCA P17252 human ADD1 11518 Q9QYC0 Add1 mouse S724 449829 KKKFRtPsFLKKSKK X +PRKCA PKCA P17252 human NR2C1 22025 Q505F1 Nr2c1 mouse S568 456552 IGNVRIDsVIPHILK X +PRKCA PKCA P17252 human p47phox 653361 P14598 NCF1 human S304 449406 GAPPRRssIRNAHsI NECFESHC X +PRKCA PKCA P17252 human AQP1 358 P29972 AQP1 human T239 482807 APRSsDLtDRVKVWT X X +PRKCA PKCA P17252 human MKLN1 27418 O89050 Mkln1 mouse S324 474504 TEKENGPsARSCHKM Kelch_3 X +PRKCA PKCA P17252 human C5aR 728 P21730 C5AR1 human S327 448821 RNVLtEEsVVREsKs X +PRKCA PKCA P17252 human SLC22A1 24904 Q63089 Slc22a1 rat S292 455611 EsPRWLLsQKRtTRA Sugar_tr X +PRKCA PKCA P17252 human CYP1A1 13076 P00184 Cyp1a1 mouse T35 471065 WVVRATRtWVPKGLK X +PRKCA PKCA P17252 human basonuclin 1 646 Q01954 BNC1 human S541 451420 KKksRKSsMPIkIEK X +PRKCA PKCA P17252 human LRRK1 79705 Q38SD2 LRRK1 human S1064 15411924 NRKVTIysFTGNQRN X +PRKCA PKCA P17252 human myelin P0 539462 P10522 MPZ cow S243 458935 KTKGLGEsRKDKK__ Myelin-PO_C X +PRKCA PKCA P17252 human H1R 3269 P35367 HRH1 human S396 453404 FTWKRLRsHsRQyVS 7tm_1 X +PRKCA PKCA P17252 human MMP2 4313 P08253 MMP2 human S160 479858 DVTPLRFsRIHDGEA Peptidase_M10 X +PRKCA PKCA P17252 human CK1D 64462 Q06486 Csnk1d rat T392 53356804 DLTGRQDtsRMstsQ X +PRKCA PKCA P17252 human K20 54474 P35900 KRT20 human S13 463823 RSFHRsLsSSLQAPV X 39359 +PRKCA PKCA P17252 human TUBA1A 7846 Q71U36 TUBA1A human S165 25757493 sVDyGkkskLEFSIy Tubulin X +PRKCA PKCA P17252 human RORA 6095 P35398 RORA human S100 1212279800 CKGFFRRsQQSNATY zf-C4 X +PRKCA PKCA P17252 human ANXA2 282689 P04272 ANXA2 cow S26 450879 TPPSAyGsVKAYTNF X X +PRKCA PKCA P17252 human PRKD2 25865 Q9BZL6 PRKD2 human S706 449864 ARIIGEksFRRsVVG Pkinase X +PRKCA PKCA P17252 human Kv4.2 Q63881 Kcnd2 rat S537 4668100 CSRRHKKsFRIPNAN DUF3399 X X +PRKCA PKCA P17252 human ADCY6 25289 Q03343 Adcy6 rat S568 455528 TFLILGAsQKRKEEK X +PRKCA PKCA P17252 human AR 11835 P19091 Ar mouse S794 1875398900 MKALLLFsIIPVDGL Hormone_recep X +PRKCA PKCA P17252 human Kir6.2 16514 Q61743 Kcnj11 mouse S372 22874702 RGPLRKRsVAVAKAK X +PRKCA PKCA P17252 human PRKD1 5587 Q15139 PRKD1 human S412 20615903 PLMRVVQsVKHTKRK X +PRKCA PKCA P17252 human PRKD2 25865 Q9BZL6 PRKD2 human S710 449865 GEksFRRsVVGtPAy Pkinase X +PRKCA PKCA P17252 human NMDAR1 24408 P35439 Grin1 rat S890 447737 ITSTLAssFKRRRss X +PRKCA PKCA P17252 human pleckstrin 5341 P08567 PLEK human S117 451306 ARKstRRsIRLPEtI X X +PRKCA PKCA P17252 human MBP 618684 P02687 MBP cow S10 456424 QKRPsQRsKYLASAs X +PRKCA PKCA P17252 human EWS 2130 Q01844 EWSR1 human S266 448028 SSYGQQSsFRQDHPS X +PRKCA PKCA P17252 human DNAM-1 10666 Q15762 CD226 human S329 450987 yVNyPTFsRRPKTRV X +PRKCA PKCA P17252 human GSK3A 2931 P49840 GSK3A human S21 448584 sGrARtssFAEPGGG X X 9337; 9316; 9331; 5090; 9327; 8452; 8566 +PRKCA PKCA P17252 human DAT 6531 Q01959 SLC6A3 human S12 451137 kCsVGLMssVVAPAK X +PRKCA PKCA P17252 human GAP43 29423 P07936 Gap43 rat S41 448719 AATkIQAsFRGHITR IQ X +PRKCA PKCA P17252 human ARX 170302 Q96QS3 ARX human S174 1297351802 VSISRSKsYRENGAP X +PRKCA PKCA P17252 human ZFP64 55734 Q9NTW7 ZFP64 human S226 7322830 NKHLRIHsDERPFKC zf-H2C2_5 X X +PRKCA PKCA P17252 human GRF-1 2909 Q9NRY4 ARHGAP35 human S1221 10406116 RRRNILRsLRRNtKK RhoGAP_pG1_pG2 X +PRKCA PKCA P17252 human TRPV1 83810 O35433 Trpv1 rat S800 450017 VPLLRDAsTRDRHAT X X +PRKCA PKCA P17252 human PODXL 192181 Q9WTQ2 Podxl rat S415 21514209 GCCHQRIsQRKDQQR CD34_antigen X +PRKCA PKCA P17252 human ANXA2 302 P07355 ANXA2 human S12 450880 HEILCkLsLEGDHst X +PRKCA PKCA P17252 human ADRA1D 146 P25100 ADRA1D human S300 1424270001 KRERGKAsEVVLRIH 7tm_1 X +PRKCA PKCA P17252 human DOR-1 18386 P32300 Oprd1 mouse S344 448552 CGRQEPGsLRRPRQA X +PRKCA PKCA P17252 human RAB37 326624 Q96AX2 RAB37 human T172 556476901 YGVPFLEtSAKTGMN Ras X +PRKCA PKCA P17252 human KCNJ8 25472 Q63664 Kcnj8 rat S379 1458601 SELSHQNsLRKRNsM X +PRKCA PKCA P17252 human p47phox 653361 P14598 NCF1 human S379 451498 DLILNRCsEstKRKL p47_phox_C X +PRKCA PKCA P17252 human FRAT1 10023 Q92837 FRAT1 human S188 471366 RLQQRRGsQPETRTG GSK-3_bind X +PRKCA PKCA P17252 human LRRK1 79705 Q38SD2 LRRK1 human T1075 1879806800 NQRNRCstFRVKRNQ X +PRKCA PKCA P17252 human MRLC1 10398 P24844 MYL9 human S3 4964100 _____MssKRAKAKt X +PRKCA PKCA P17252 human APLP2 334 Q06481 APLP2 human T723 11500600 LRKRQYGtISHGIVE APP_amyloid X +PRKCA PKCA P17252 human GHSR 2693 Q92847 GHSR human T261 25293461 RDQNHKQtVKMLAVV 7tm_1 X +PRKCA PKCA P17252 human H1R 3269 P35367 HRH1 human T478 453403 CNENFKKtFKRILHI X +PRKCA PKCA P17252 human AT2 24182 P35351 Agtr2 rat S354 469106 MsCRKSSsLREMDTF X +PRKCA PKCA P17252 human GluR-delta2 14804 Q61625 Grid2 mouse S945 3595502 QTLSRTLsAkAASGF X +PRKCA PKCA P17252 human IRS1 25467 P35570 Irs1 rat S612 447562 DDGyMPMsPGVAPVP X 3193; 2386; 3203 +PRKCA PKCA P17252 human MARCKS 4082 P29966 MARCKS human S159 447786 kkKKKRFsFkKsFkL MARCKS X X 2741; 11992 +PRKCA PKCA P17252 human CELF1 10658 Q92879 CELF1 human S241 29668004 LLQQTASsGNLNTLS X +PRKCA PKCA P17252 human NMDAR1 24408 P35439 Grin1 rat S896 448255 ssFKRRRssKDtSTG X +PRKCA PKCA P17252 human ATP1A1 24211 P06685 Atp1a1 rat S23 449087 sEHGDkkskkAKKER X 4006 +PRKCA PKCA P17252 human CYP2E1 1571 P05181 CYP2E1 human S129 455561 WKDIRRFsLttLRNY p450 X +PRKCA PKCA P17252 human NOX5 iso4 79400 Q96PH1-4 NOX5 human S498 472626 RSVtMRKsQRSsKGS FAD_binding_8 X X +PRKCA PKCA P17252 human TAGLN2 8407 P37802 TAGLN2 human S185 1983445 MGtNrGAsQAGMtGy Calponin X +PRKCA PKCA P17252 human BEST1 7439 O76090 BEST1 human S358 9720901 SAQFRRAsFMGSTFN X +PRKCA PKCA P17252 human ephexin-5 442801 Q5FWH6 Arhgef15 mouse S107 17546056 PSPVSRRsIsPEPAP X X +PRKCA PKCA P17252 human HNF4 alpha 25735 P22449 Hnf4a rat S87 478421 CKGFFRRsVRKNHMY zf-C4 X +PRKCA PKCA P17252 human ITGB4 3691 P16144 ITGB4 human S1360 451654 VLRsPSGsQRPsVSD X X +PRKCA PKCA P17252 human TRPV1 7442 Q8NER1 TRPV1 human S801 450017 VPLLREAsARDRQsA X +PRKCA PKCA P17252 human CYP3A4 1576 P08684 CYP3A4 human T92 22553302 TDPDMIKtVLVKECY p450 X +PRKCA PKCA P17252 human GluR6 14806 P39087 Grik2 mouse S868 478417 MVEELRMsLKCQRRL X X +PRKCA PKCA P17252 human MRLC1 10398 P24844 MYL9 human T10 4964102 sKRAKAKttKKRPQR X X +PRKCA PKCA P17252 human GAP43 281777 P06836 GAP43 cow S41 448719 AATKIQAsFRGHITR IQ X +PRKCA PKCA P17252 human CYP2E1 1571 P05181 CYP2E1 human T58 23940004 KNIPKsFtRLAQRFG p450 X +PRKCA PKCA P17252 human NHERF 26941 P70441 Nherf1 mouse S77 957200 ETHQQVVsRIRAALN PDZ X +PRKCA PKCA P17252 human hnRNP A1 29578 P04256 Hnrnpa1 rat S199 451555 sQRGRsGsGNFGGGr X +PRKCA PKCA P17252 human MARCKS 396473 P16527 MARCKS chicken S128 447787 KRFsFKKsFKLsGFs MARCKS X 11992 +PRKCA PKCA P17252 human DTNB 1838 O60941 DTNB human T179 27100601 KEVLKLPtAVFEGPS EF-hand_3 X +PRKCA PKCA P17252 human APPL 26060 Q9UKG1 APPL1 human S430 13204434 ARTSssGsLGSESTN X +PRKCA PKCA P17252 human HER2 2064 P04626 ERBB2 human T686 451817 QQKIRKYtMRRLLQE X 88583 +PRKCA PKCA P17252 human TNNT2 21956 P50752 Tnnt2 mouse S288 457603 INDNQkVsKTRGKAK Troponin X +PRKCA PKCA P17252 human Claudin-4 1364 O14493 CLDN4 human S194 4199301 PRTDKPysAKysAAR X +PRKCA PKCA P17252 human MMP2 4313 P08253 MMP2 human T378 479861 GKMWCAttANYDDDR Peptidase_M10; fn2 X +PRKCA PKCA P17252 human GluR5 29559 P22756 Grik1 rat S929 457627 KsRTKGKsSFTSILT X +PRKCA PKCA P17252 human LRP1 4035 Q07954 LRP1 human S4520 450168 GGHGsRHsLAsTDEk X X +PRKCA PKCA P17252 human ATP4A 397552 P19156 ATP4A pig S27 3189202 GDMAAKMsKKKAGRG H-K_ATPase_N X +PRKCA PKCA P17252 human SLC22A1 24904 Q63089 Slc22a1 rat T296 455612 WLLsQKRtTRAVRIM Sugar_tr X +PRKCA PKCA P17252 human TNNI3 511094 P08057 TNNI3 cow S24 448423 PPPVRRRssANYRAY Troponin-I_N X +PRKCA PKCA P17252 human TNNI3 7137 P19429 TNNI3 human S199 4707844 RkNIDALsGMEGRKK X +PRKCA PKCA P17252 human KCC2 171373 Q63633 Slc12a5 rat S963 487533 ITDESRGsIRRKNPA SLC12 X X +PRKCA PKCA P17252 human ABCB1 5243 P08183 ABCB1 human S661 456983 SSNDSRSsLIRKRsT X +PRKCA PKCA P17252 human Src 396442 P00523 SRC chicken S12 448230 KSKPKDPsQRRRsLE X X +PRKCA PKCA P17252 human Cortactin 60465 A6HYF4 Cttn rat S135 31881968 QMDRVDQsAVGFEYQ HS1_rep X +PRKCA PKCA P17252 human TRPV1 83810 O35433 Trpv1 rat S502 450016 YFLQRRPsLKSLFVD Ion_trans X X +PRKCA PKCA P17252 human NR1H4 iso2 9971 Q96RI1-2 NR1H4 human S135 4245801 VVCGDRAsGYHYNAL zf-C4 X X +PRKCA PKCA P17252 human AKAP12 83425 Q5QD51 Akap12 rat S515 469988 SsGLKKLsGKKQKGK X +PRKCA PKCA P17252 human TRPV1 83810 O35433 Trpv1 rat S774 456217 EGVKRTLsFSLRSGR X +PRKCA PKCA P17252 human DYNC1I2 116659 Q62871 Dync1i2 rat S89 3195347 VPPPMSPssKSVstP X +PRKCA PKCA P17252 human MBD4 8930 O95243 MBD4 human S262 22730000 sGFVQSDsKRESVCN X +PRKCA PKCA P17252 human ROMK 3758 P48048 KCNJ1 human S201 2813508 FSKNAVIskRGGKLC IRK_C X +PRKCA PKCA P17252 human Tau iso8 4137 P10636-8 MAPT human S258 487453 PDLkNVKskIGstEN Tubulin-binding X +PRKCA PKCA P17252 human ABCB1 5243 P08183 ABCB1 human S667 455363 SsLIRKRsTRRsVRG X +PRKCA PKCA P17252 human Cofilin-1 1072 P23528 CFL1 human S24 9218418 DMkVRksstPEEVkk Cofilin_ADF X X +PRKCA PKCA P17252 human NHERF 9368 O14745 NHERF1 human S162 450312 CtMKKGPsGyGFNLH PDZ X +PRKCA PKCA P17252 human p53 7157 P04637 TP53 human T377 3309800 kskkGQstsRHkkLM X +PRKCA PKCA P17252 human PANX1 24145 Q96RD7 PANX1 human Y199 462886 KYPIVEQyLkTkkNS Innexin X +PRKCA PKCA P17252 human SNAP-25 6616 P60880 SNAP25 human S187 448668 RIMEKADsNKTRIDE X X +PRKCA PKCA P17252 human ANXA1 301 P04083 ANXA1 human S27 447972 EyVQtVksskGGPGs X +PRKCA PKCA P17252 human DOCK8 81704 Q8NF50 DOCK8 human S2087 4041179 RDsFHRSsFRKCETQ X +PRKCA PKCA P17252 human RALBP1 10928 Q15311 RALBP1 human S353 3136102 LSPTVQIsNRVLYVF RhoGAP X +PRKCA PKCA P17252 human CYP3A4 1576 P08684 CYP3A4 human S139 15499923 LLsPtFTsGKLKEMV p450 X +PRKCA PKCA P17252 human PAK5 57144 Q9P286 PAK5 human S99 29574070 ISVTRSNsLRKESPP X +PRKCA PKCA P17252 human cytohesin 2 9266 Q99418 CYTH2 human S392 450661 AARKKRIsVKKKQEQ X +PRKCA PKCA P17252 human ATF-2 1386 P15336 ATF2 human S121 6406001 LAtPIIRsKIEEPSV X +PRKCA PKCA P17252 human CTNND1 1500 O60716 CTNND1 human S879 450459 LIDRNQksDkkPDRE X +PRKCA PKCA P17252 human PICK1 84591 Q9EP80 Pick1 rat S77 23045800 ITGVNGRsIKGKtKV PDZ X +PRKCA PKCA P17252 human MARCKS 613548 P12624 MARCKS cow S166 466360 FKKsFKLsGFsFKKN MARCKS X 8722 +PRKCA PKCA P17252 human profilin 1 513895 P02584 PFN1 cow S138 2850008 MASHLRRsQY_____ Profilin X +PRKCA PKCA P17252 human MBD4 8930 O95243 MBD4 human S165 22730001 CSMAALTsHLQNQSN X +PRKCA PKCA P17252 human HOXA9 15405 P09631 Hoxa9 mouse T205 2906101 NWLHARstRKKRCPY X +PRKCA PKCA P17252 human CYP2E1 1571 P05181 CYP2E1 human S74 23940006 VFtLYVGsQRMVVMH p450 X +PRKCA PKCA P17252 human KIR3DL1 3811 P43629 KIR3DL1 human S415 990302 QRKITRPsQRPKtPP X +PRKCA PKCA P17252 human MARCKS 4082 P29966 MARCKS human S167 466360 FkKsFkLsGFsFkKN MARCKS X 8722 +PRKCA PKCA P17252 human CACNA1C 12288 Q01815 Cacna1c mouse S1897 455278 ASLGRRAsFHLECLK CAC1F_C X +PRKCA PKCA P17252 human PDE3A 5139 Q14432 PDE3A human S292 471415 VFkRRRRsssVVsAE X +PRKCA PKCA P17252 human CD36 948 P16671 CD36 human T92 23017300 VKQRGPYtYRVRFLA CD36 X +PRKCA PKCA P17252 human p53 7157 P04637 TP53 human S371 447533 AHssHLkskkGQsts X +PRKCA PKCA P17252 human Titin 7273 Q8WZ42 TTN human S12022 4693667 RRKLRPGsGGEKPPD X +PRKCA PKCA P17252 human GSK3B 2932 P49841 GSK3B human S9 449111 SGRPRttsFAEsCkP X X 9336; 9331; 9327; 9323; 9322; 9325; 5558; 8566; 79774; 8466; 25462; 14026; 14332; 14310; 14630 +PRKCA PKCA P17252 human LRRK1 79705 Q38SD2 LRRK1 human S1074 1879806802 GNQRNRCstFRVKRN X +PRKCA PKCA P17252 human PLM 5348 O00168 FXYD1 human S88 451425 RssIRRLstRRR___ X +PRKCA PKCA P17252 human fascin 6624 Q16658 FSCN1 human S39 450888 KVNASAssLkkkQIW Fascin X X +PRKCA PKCA P17252 human VTN 7448 P04004 VTN human S386 452176 YRsQRGHsRGRNQNs X +PRKCA PKCA P17252 human PPP1R1A 58977 P19103 Ppp1r1a rat S67 447758 LKSTLsMsPRQRKKM DARPP-32 X +PRKCA PKCA P17252 human HuR 1994 Q15717 ELAVL1 human S221 478357 QAQrFrFsPMGVDHM X +PRKCA PKCA P17252 human TACSTD2 4070 P09758 TACSTD2 human S322 470219 GELRkEPsL______ X +PRKCA PKCA P17252 human RALBP1 10928 Q15311 RALBP1 human S509 3136100 FLRRQIAsEKEEIER X +PRKCA PKCA P17252 human Ebp1 5036 Q9UQ80 PA2G4 human S360 478276 ELkALLQssAsRKtQ X +PRKCA PKCA P17252 human NF1 iso2 4763 P21359-2 NF1 human S2808 456895 QKQRSAGsFKRNsIK X +PRKCA PKCA P17252 human SNAP-25 25012 P60881 Snap25 rat S187 448668 RIMEkADsNkTRIDE X +PRKCA PKCA P17252 human RKIP 5037 P30086 PEBP1 human S153 448755 RGKFkVAsFRKKYEL PBP X +PRKCA PKCA P17252 human DYN1 1759 Q05193 DNM1 human S778 450206 GRRsPtssPtPQRRA X +PRKCA PKCA P17252 human RAF1 5894 P04049 RAF1 human S499 450237 VksRWsGsQQVEQPT PK_Tyr_Ser-Thr X X +PRKCA PKCA P17252 human C5aR 728 P21730 C5AR1 human S338 448820 EsKsFTRsTVDTMAQ X +PRKCA PKCA P17252 human PRKD3 23683 O94806 PRKD3 human S731 456755 ARIIGEksFRRsVVG Pkinase X +PRKCA PKCA P17252 human AR 367 P10275 AR human S579 4275600 YGALTCGsCKVFFKR zf-C4 X X +PRKCA PKCA P17252 human PTPRA 19262 P18052 Ptpra mouse S204 447612 PLLARsPstNRKYPP X +PRKCA PKCA P17252 human PDE3A 5139 Q14432 PDE3A human S428 456821 IPKRLRRsLPPGLLR X X +PRKCA PKCA P17252 human CYP2E1 1571 P05181 CYP2E1 human T132 23940010 IRRFsLttLRNYGMG p450 X +PRKCA PKCA P17252 human Bcl-2 596 P10415 BCL2 human S70 448395 RDPVARtsPLQtPAA X X 2834; 2827 +PRKCA PKCA P17252 human TRPM2 28240 Q91YD4 Trpm2 mouse T738 1879806400 GGIQAFLtKVWWGQL X +PRKCA PKCA P17252 human PLM 58971 O08589 Fxyd1 rat S83 451424 EEGtFRSsIRRLstR X +PRKCA PKCA P17252 human CELF1 10658 Q92879 CELF1 human S52 25733984 INVLRDRsQNPPQSk RRM_1 X +PRKCA PKCA P17252 human PACSIN2 11252 Q9UNF0 PACSIN2 human S313 4786393 ADLNRtLsRREKKKA X +PRKCA PKCA P17252 human JAM-A 50848 Q9Y624 F11R human S284 467829 kVIysQPsARsEGEF X X +PRKCA PKCA P17252 human ABCB1 5243 P08183 ABCB1 human S671 455365 RKRsTRRsVRGsQAQ X +PRKCA PKCA P17252 human ADRA1D 146 P25100 ADRA1D human S323 1424270002 DGAHGMRsAKGHtFR 7tm_1 X +PRKCA PKCA P17252 human hnRNP A1 29578 P04256 Hnrnpa1 rat T103 2874414 QRPGAHLtVKKIFVG X +PRKCA PKCA P17252 human CYP3A4 1576 P08684 CYP3A4 human T136 22553304 LRsLLsPtFTsGKLK p450 X +PRKCA PKCA P17252 human P70S6KB 6199 Q9UBS0 RPS6KB2 human S473 450071 PPSGTKKsKRGRGRP X X +PRKCA PKCA P17252 human SATB1 6304 Q01826 SATB1 human S185 464645 DLPPEQWsHTtVRNA CUTL X X +PRKCA PKCA P17252 human CD4 920 P01730 CD4 human S433 451188 RRQAERMsQIkRLLs Tcell_CD4_C X +PRKCA PKCA P17252 human PLM 58971 O08589 Fxyd1 rat S88 451425 RSsIRRLstRRR___ X +PRKCA PKCA P17252 human PTP-PEST 5782 Q05209 PTPN12 human S39 451311 FMRLRRLstKYRTEK X X +PRKCA PKCA P17252 human IREB1 48 P21399 ACO1 human S711 455225 REFNSYGsRrGNDAV Aconitase_C X +PRKCA PKCA P17252 human TXA2-R 6915 P21731 TBXA2R human S145 469630 FSRPAVAsQRRAWAT 7tm_1 X +PRKCA PKCA P17252 human MAP4 281295 P36225 MAP4 cow S815 4001700 PKSTTTSsVKKSTTV X +PRKCA PKCA P17252 human SNAP-25 6616 P60880 SNAP25 human T138 449875 GGFIRRVtNDARENE SNAP-25 X +PRKCA PKCA P17252 human INSR 3643 P06213 INSR human S1064 451563 kTVNEsAsLRERIEF PK_Tyr_Ser-Thr X +PRKCA PKCA P17252 human RAF1 5894 P04049 RAF1 human S43 447744 FGyQRRAsDDGKLtD X +PRKCA PKCA P17252 human FMNL2 iso3 114793 Q96PY5-3 FMNL2 human S1072 48891101 RADAVRRsVRRRFDD X X +PRKCA PKCA P17252 human RORA 6095 P35398 RORA human S35 12613703 ETPLNQEsArKSEPP X X +PRKCA PKCA P17252 human SLC18A2 6571 Q05940 SLC18A2 human S18 30332701 WLQEsRRsRKLILFI X +PRKCA PKCA P17252 human MMP2 4313 P08253 MMP2 human S365 479863 NKyEsCtsAGRsDGK Peptidase_M10; fn2 X +PRKCA PKCA P17252 human CACNA1C 100101555 P15381 CACB rabbit S1842 9808100 QEAAWKLssKRCHSQ CAC1F_C X +PRKCA PKCA P17252 human SH2-B-beta 25970 Q9NRF2 SH2B1 human S161 21336502 sLRsVGRsVRGsVRG X +PRKCA PKCA P17252 human RIGI 23586 O95786 RIGI human S8 12613701 MTTEQRRsLQAFQDY CARD_2 X X +PRKCA PKCA P17252 human Ebp1 5036 Q9UQ80 PA2G4 human T366 3850595 QssAsRKtQKKKKKk X +PRKCA PKCA P17252 human HMGA1 117062 Q8K585 Hmga1 rat S44 479856 PGTALVGsQKEPSEV X +PRKCA PKCA P17252 human Ret 5979 P07949 RET human T675 22553316 PISSAEMtFRRPAQA X +PRKCA PKCA P17252 human CYSLTR1 10800 Q9Y271 CYSLTR1 human S316 11146368 FRKHsLssVTYVPRK X +PRKCA PKCA P17252 human ADCY2 81636 P26769 Adcy2 rat S543 25795202 NRTLRTKsQKKRFEE Adcy_cons_dom X +PRKCA PKCA P17252 human CFLAR iso2 8837 O15519-2 CFLAR human S193 7590803 LQAAIQKsLKDPSNN X +PRKCA PKCA P17252 human GJA1 24392 P08050 Gja1 rat S368 447813 QRPssRAssRAssRP X 3511; 52559 +PRKCA PKCA P17252 human GRK2 156 P25098 GRK2 human S29 447724 ATPAARAskkILLPE X +PRKCA PKCA P17252 human Vimentin 7431 P08670 VIM human S10 455451 trsVssssyrrMFGG Filament_head X +PRKCA PKCA P17252 human PITPNC1 26207 Q9UKF7 PITPNC1 human S299 478664 KDRPRKKsAPEtLtL X +PRKCA PKCA P17252 human C5aR 728 P21730 C5AR1 human S334 448819 sVVREsKsFTRsTVD X +PRKCA PKCA P17252 human Vimentin 7431 P08670 VIM human S5 471086 ___MStrsVssssyr X +PRKCA PKCA P17252 human eIF4G 1981 Q04637 EIF4G1 human S1185 482920 RtPATKRsFskEVEE X X +PRKCA PKCA P17252 human TRPC3 7222 Q13507 TRPC3 human S785 454431 PPFsLVPsPKsFVyF X +PRKCA PKCA P17252 human SPHK1 20698 Q8CI15 Sphk1 mouse S373 51621300 DAPSGRDsRRGPPPE X X +PRKCA PKCA P17252 human NHERF 9368 O14745 NHERF1 human S77 957200 ETHQQVVsRIRAALN PDZ X +PRKCA PKCA P17252 human Kv3.4 3749 Q03721 KCNC4 human S15 451077 ssYRGRKsGNKPPsK Potassium_chann X +PRKCA PKCA P17252 human Claudin-1 9076 O95832 CLDN1 human T191 1869121000 CSCPRkTtsYPtPRP X +PRKCA PKCA P17252 human CTPS 1503 P17812 CTPS1 human S462 479852 tLFQTkNsVMRkLYG GATase X X +PRKCA PKCA P17252 human CK1D 64462 Q06486 Csnk1d rat T397 3362909 QDtsRMstsQIPGRV X +PRKCA PKCA P17252 human TNNI3 511094 P08057 TNNI3 cow T145 451483 RGKFKRPtLRRVRIS Troponin X +PRKCA PKCA P17252 human TGFBR1 7046 P36897 TGFBR1 human T200 4325704 LPLLVQRtIARtIVL TGF_beta_GS X X +PRKCA PKCA P17252 human IQGAP1 8826 P46940 IQGAP1 human S1443 454416 DKMKKsksVkEDsNL X X +PRKCA PKCA P17252 human EAR-2 2063 P10588 NR2F6 human S83 25802106 CKSFFKRsIRRNLsY zf-C4 X +PRKCA PKCA P17252 human KLHL3 26249 Q9UH77 KLHL3 human S433 36440206 PMNTRRSsVGVGVVE Kelch_1 X X +PRKCA PKCA P17252 human NFL 100521224 P02547 NEFL pig S28 457197 TPRVHISsVRSGYsT Filament_head X +PRKCA PKCA P17252 human TXA2-R iso2 6915 P21731-2 TBXA2R human T399 451396 LLPFEPPtGKALSRK X +PRKCA PKCA P17252 human PPP1R1A 5502 Q13522 PPP1R1A human S67 447758 LKSTLAMsPRQRKKM DARPP-32 X +PRKCA PKCA P17252 human CK1D 1453 P48730 CSNK1D human T161 1871153000 KKYRDARtHQHIPYR Pkinase X +PRKCA PKCA P17252 human CACNA1C 100101555 P15381 CACB rabbit S528 486358 ARLAHRIsKSKFsRY X +PRKCA PKCA P17252 human MOR-1 18390 P42866 Oprm1 mouse T370 447785 sARIRQNtREHPstA X +PRKCA PKCA P17252 human HuR 1994 Q15717 ELAVL1 human S158 478356 FIRFDKRsEAEEAIT RRM_1 X +PRKCA PKCA P17252 human PRKD1 5587 Q15139 PRKD1 human S738 448589 ARIIGEksFRRsVVG Pkinase X X 2054 +PRKCA PKCA P17252 human GJA1 2697 P17302 GJA1 human S372 465460 sRAssRAssRPRPDD X +PRKCA PKCA P17252 human GRF-1 2909 Q9NRY4 ARHGAP35 human T1226 7159800 LRsLRRNtKKPKPKP RhoGAP_pG1_pG2 X +PRKCA PKCA P17252 human HuR 1994 Q15717 ELAVL1 human S318 2246702 GDkILQVsFkTNkSH X +PRKCA PKCA P17252 human TNNT2 21956 P50752 Tnnt2 mouse T216 451556 RKsGKRQtEREKKKK Troponin X +PRKCA PKCA P17252 human PDE3A 5139 Q14432 PDE3A human S312 456900 SKSHRRTsLPCIPRE X X +PRKCA PKCA P17252 human KCNJ8 25472 Q63664 Kcnj8 rat S385 483976 NsLRKRNsMRRNNsM X +PRKCA PKCA P17252 human ANXA5 iso3 AAB24205 ANXA5 cow T22 2358301 DERADAEtLRKAMKG Annexin X +PRKCA PKCA P17252 human GluR6 54257 P42260 Grik2 rat S846 11496000 VGEFLYKsKKNAQLE X +PRKCA PKCA P17252 human Kit 3815 P10721 KIT human S741 450035 TkADkRRsVRIGsyI PK_Tyr_Ser-Thr X +PRKCA PKCA P17252 human CREM 12916 P27699 Crem mouse S133 448412 EILSRRPsYRKILNE pKID X 4095; 14228; 14001 +PRKCA PKCA P17252 human coronin 1B 57175 Q9BR76 CORO1B human S2 456131 ______MsFRKVVRQ X X +PRKCA PKCA P17252 human SNAP-25 20614 P60879 Snap25 mouse S187 448668 RIMEkADsNkTRIDE X +PRKCA PKCA P17252 human AA-NAT 25120 Q64666 Aanat rat T29 452141 LGCQRRHtLPASEFR X +PRKCA PKCA P17252 human CFTR 1080 P13569 CFTR human S660 449979 FSAERRNsILTETLH CFTR_R X +PRKCA PKCA P17252 human PPAR-alpha 25747 P37230 Ppara rat S142 457550 AYDKCDRsCKIQKKN zf-C4 X +PRKCA PKCA P17252 human CK1D 64462 Q06486 Csnk1d rat T329 31869461 ATRGLPstAsGRLRG X +PRKCA PKCA P17252 human GluR1 14799 P23818 Gria1 mouse T858 3362100 NEAIRtstLPRNsGA X X +PRKCA PKCA P17252 human GJA1 24392 P08050 Gja1 rat S369 459208 RPssRAssRAssRPR X +PRKCA PKCA P17252 human SLC22A1 24904 Q63089 Slc22a1 rat S286 455610 YYWFVPEsPRWLLsQ Sugar_tr X +PRKCA PKCA P17252 human KCNJ13 3769 O60928 KCNJ13 human S201 6039502 TRPSPLTsVRVSAVL IRK_C X +PRKCA PKCA P17252 human Claudin-7 1366 O95471 CLDN7 human S204 27732000 VPRsYPksNsskEyV X +PRKCA PKCA P17252 human PLCD1 P10688 Plcd1 rat S35 9993602 LLKVKSSsWRRERFY PH_12 X +PRKCA PKCA P17252 human PDE3A 5139 Q14432 PDE3A human S438 456984 PGLLRRVsstWtttt X X +PRKCA PKCA P17252 human SLC1A1 25550 P51907 Slc1a1 rat S465 471076 TGIVEKLsKKELEQV X +PRKCA PKCA P17252 human CDK1 396252 P13863 CDK1 chicken S277 465625 YDPAKRIsGKMALNH Pkinase X +PRKCA PKCA P17252 human GUCY2C 397193 P55204 GUCY2C pig S1052 451300 RKPTRVAsYKKGTLE X +PRKCA PKCA P17252 human KRas iso2 3845 P01116-2 KRAS human S181 459210 GKKKKkKskTkCVIM X +PRKCA PKCA P17252 human TH 25085 P04177 Th rat S40 448545 RFIGRRQsLIEDARK TOH_N X 2791 +PRKCA PKCA P17252 human APLP1 11803 Q03157 Aplp1 mouse T615 11500601 RKKKPYGtISHGVVE APP_amyloid X +PRKCA PKCA P17252 human PDE3A 5139 Q14432 PDE3A human S492 4787245 MTLTkSRsFtSSyAI X X +PRKCA PKCA P17252 human CACNA1C 24239 P22002 Cacna1c rat S1927 455278 ASLGRRAsFHLECLK CAC1F_C X X +PRKCA PKCA P17252 human SHOC2 8036 Q9UQ13 SHOC2 human S297 31905007 GLRYNRLsAIPRSLA LRR_8 X +PRKCA PKCA P17252 human Kv7.2 170848 O88943 Kcnq2 rat S541 11082901 sKRKFKEsLRPYDVM KCNQ_channel X +PRKCA PKCA P17252 human p47phox 653361 P14598 NCF1 human S315 451725 AHsIHQRsRKRLsQD NECFESHC X +PRKCA PKCA P17252 human CFTR 1080 P13569 CFTR human S686 449980 WTEtKKQsFKQTGEF CFTR_R X +PRKCA PKCA P17252 human CYP3A4 1576 P08684 CYP3A4 human S398 22553308 GVVVMIPsYALHRDP p450 X +PRKCA PKCA P17252 human SHP-1 5777 P29350 PTPN6 human S591 454019 DKEKsKGsLKRK___ X X +PRKCA PKCA P17252 human ADD2 119 P35612 ADD2 human S713 449802 KKKFRtPsFLKKsKK X +PRKCA PKCA P17252 human G-alpha(z) 2781 P19086 GNAZ human S27 451241 DRHLRSEsQRQRREI G-alpha X X +PRKCA PKCA P17252 human JAK2 3717 O60674 JAK2 human T174 56527200 kVPVTHEtQEECLGM FERM_F2 X +PRKCA PKCA P17252 human Kv4.2 Q63881 Kcnd2 rat S447 4668101 SANAYMQsKRNGLLS X +PRKCA PKCA P17252 human Cortactin 60465 A6HYF4 Cttn rat S172 15176497 QADRVDKsAVGFDYQ HS1_rep X +PRKCA PKCA P17252 human SERT 6532 P31645 SLC6A4 human S277 31014802 IWKGVKtsGKVVWVT SNF X +PRKCA PKCA P17252 human NR1I3 9970 Q14994 NR1I3 human T38 11281700 CKGFFRRtVSKSIGP zf-C4 X +PRKCA PKCA P17252 human AHR 196 P35869 AHR human S12 451412 SANITYAsRKRRKPV X +PRKCA PKCA P17252 human HIR 3761 P48050 KCNJ4 human T53 450871 IFTTCVDtRWRYMLM IRK X +PRKCA PKCA P17252 human SPIC 121599 Q8N5J4 SPIC human Y191 15570419 KIRRKLTyQFSEAIL Ets X +PRKCA PKCA P17252 human DYNC1I2 116659 Q62871 Dync1i2 rat S90 4033130 PPPMSPssKSVstPs X +PRKCA PKCA P17252 human PITPNB 114561 P53812 Pitpnb rat S262 451299 ETMRKKGsVRGTSAA X +PRKCA PKCA P17252 human ADD1 118 P35611 ADD1 human S726 449829 KKKFRtPsFLKKsKK X +PRKCA PKCA P17252 human CFLAR 8837 O15519 CFLAR human S193 7590803 LQAAIQksLkDPSNN X +PRKCA PKCA P17252 human RGS7 6000 P49802 RGS7 human S434 455540 YKLMKSDsYPRFIRS RGS X +PRKCA PKCA P17252 human neurogranin 616955 P35722 NRGN cow S36 455913 AAAKIQAsFRGHMAR IQ X +PRKCA PKCA P17252 human Kv7.2 3785 O43526 KCNQ2 human T217 457689 RMDRRGGtWKLLGSV Ion_trans; TM X X +PRKCA PKCA P17252 human PDE3A 5139 Q14432 PDE3A human S465 456985 VRRDRsTsIkLQEAP X X +PRKCA PKCA P17252 human SLC22A1 24904 Q63089 Slc22a1 rat S328 455613 LCLEEDAsEKRSPsF Sugar_tr X +PRKCA PKCA P17252 human MBP 618684 P02687 MBP cow S54 451832 RGAPKRGsGKDGHHA Myelin_MBP X +PRKCA PKCA P17252 human S6 29304 P62755 Rps6 rat S236 448093 AKRRRLssLRAstsK X 5006; 4856; 4857; 4858; 4851; 4803; 2211; 3945; 3985; 5316; 4854; 8520; 48319; 40643; 9865; 38573; 14733; 27036; 34411; 62016; 62788; 81736; 97935; 99457; 15448 +PRKCA PKCA P17252 human PPAR-gamma 5468 P37231 PPARG human T166 1880248400 CKGFFRRtIRLKLIY X X +PRKCA PKCA P17252 human CYBA 13057 Q61462 Cyba mouse T147 7103047 ERPQVGGtIkQPPTN Cytochrom_B558a X +PRKCA PKCA P17252 human NHERF E2RGF3 SLC9A3R1 dog S348 455752 ERAHQKRssKRAPQM EBP50_C X X +PRKCA PKCA P17252 human NOX5 iso4 79400 Q96PH1-4 NOX5 human S490 20612401 GRGSKRLsRSVtMRK FAD_binding_8 X X +PRKCA PKCA P17252 human NFL 100521224 P02547 NEFL pig S13 457195 SEPYYSTsYKRRYVE Filament_head X +PRKCA PKCA P17252 human CYP3A4 1576 P08684 CYP3A4 human S119 22553300 GFMksAIsIAEDEEW p450 X +PRKCA PKCA P17252 human GPSM2 29899 P81274 GPSM2 human S408 4766076 PKLGRRHsMENMELM X +PRKCA PKCA P17252 human Pim1 iso2 5292 P11309-2 PIM1 human S65 1190526800 HSHSPRHsLRHSPGS X X +PRKCA PKCA P17252 human p47phox 653361 P14598 NCF1 human S328 449404 QDAYRRNsVRFLQQR NECFESHC X +PRKCA PKCA P17252 human RASSF1 iso2 11186 Q9NS23-2 RASSF1 human S197 18748000 RGPGRGTsVRRRtsF X X +PRKCA PKCA P17252 human p40phox 4689 Q15080 NCF4 human T154 448266 LRRLRPRtRKVKSVs X X 4311 +PRKCA PKCA P17252 human CACNA1B 257648 Q02294 Cacna1b rat S898 455281 ARPRRsHsKEAPGAD X +PRKCA PKCA P17252 human CYP3A4 1576 P08684 CYP3A4 human S420 5938007 kFLPERFsKKNKDNI p450 X +PRKCA PKCA P17252 human NKX3-1 4824 Q99801 NKX3-1 human S48 3078000 RQGGRTSsQRQRDPE X X +PRKCA PKCA P17252 human NMDAR2C 24411 Q00961 Grin2c rat S1231 463822 SCTWRRVssLEsEV_ X X +PRKCA PKCA P17252 human p53 7157 P04637 TP53 human S378 447534 skkGQstsRHkkLMF X +PRKCA PKCA P17252 human occludin 18260 Q61146 Ocln mouse S338 455819 GKRSYPEsFYKSTPL X +PRKCA PKCA P17252 human ROBO3 64221 Q96MS0 ROBO3 human S1330 15414501 WLPYSRPsFLSrGQG X X +PRKCA PKCA P17252 human CD5 921 P06127 CD5 human T434 450129 MsFHRNHtAtVRsHA X +PRKCA PKCA P17252 human DAT 6531 Q01959 SLC6A3 human S7 451136 _MsKskCsVGLMssV X +PRKCA PKCA P17252 human p73 7161 O15350 TP73 human S388 6417400 VPQPLVDsYRQQQQL X +PRKCA PKCA P17252 human GNMT 27232 Q14749 GNMT human S10 460706 DSVYRtRsLGVAAEG X +PRKCA PKCA P17252 human CHAT iso3 1103 P28329-3 CHAT human S476 454037 HKAAVPAsEKLLLLK Carn_acyltransf X +PRKCA PKCA P17252 human PCYT2 68671 Q922E4 Pcyt2 mouse S215 31834925 VsQFLQTsQKIIQFA X +PRKCA PKCA P17252 human AFAP 60312 Q8N556 AFAP1 human S277 2853100 AELEKKLssERPssD X +PRKCA PKCA P17252 human MBP 618684 P02687 MBP cow S160 456582 FKLGGRDsRSGsPMA Myelin_MBP X +PRKCA PKCA P17252 human PPP1R16B 26051 Q96T49 PPP1R16B human S331 62459400 sQLRHKSsLsRRTsS X X +PRKCA PKCA P17252 human PTPRA 19262 P18052 Ptpra mouse S180 447611 QAGsHSNsFRLSNGR X +PRKCA PKCA P17252 human VDR 7421 P11473 VDR human S51 451285 CKGFFRRsMKRKALF zf-C4 X +PRKCA PKCA P17252 human PEA-15 100736554 Q9Z297 Pea15 hamster S104 455750 TKLTRIPsAKKYKDI X +PRKCA PKCA P17252 human MMP2 4313 P08253 MMP2 human T250 479859 EYNsCTDtGRSDGFL Peptidase_M10; fn2 X +PRKCA PKCA P17252 human F3 2152 P13726 F3 human S290 451613 GQsWkENsPLNVs__ X +PRKCA PKCA P17252 human hnRNP A1 29578 P04256 Hnrnpa1 rat S231 2874411 GrGGFGGsrGGGGYG X +PRKCA PKCA P17252 human MRLC1 10398 P24844 MYL9 human S2 4964101 ______MssKRAKAK X +PRKCA PKCA P17252 human GJA1 2697 P17302 GJA1 human S368 447813 QRPssRAssRAssRP X X 3511; 52559 +PRKCA PKCA P17252 human CYP2E1 1571 P05181 CYP2E1 human T373 23940002 SNLPHEAtRDtIFrG p450 X +PRKCA PKCA P17252 human ephexin-5 442801 Q5FWH6 Arhgef15 mouse S109 17546059 PVSRRsIsPEPAPCS X X +PRKCA PKCA P17252 human ADRA1D 146 P25100 ADRA1D human S516 1346843003 QLRAKVssLsHKIRA X +PRKCA PKCA P17252 human KCNK9 51305 Q9NPC2 KCNK9 human T341 40686300 IEEISPStLKNSLFP X +PRKCA PKCA P17252 human CELF1 10658 Q92879 CELF1 human S178 29668006 AQtMEGCssPMVVkF RRM_1 X +PRKCA PKCA P17252 human TNNT2 286816 P13789 TNNT2 cow T281 451557 TRGKAKVtGRWK___ X +PRKCA PKCA P17252 human NG2 81651 Q00657 Cspg4 rat T2256 454952 YLRKRNKtGKHDVQV X X +PRKCA PKCA P17252 human CYP3A4 1576 P08684 CYP3A4 human S134 17547617 kRLRsLLsPtFTsGK p450 X +PRKCA PKCA P17252 human TNNI3 29248 P23693 Tnni3 rat S24 448424 APVRRRssANYRAYA Troponin-I_N X 4004 +PRKCA PKCA P17252 human STXBP1 25558 P61765 Stxbp1 rat S313 448744 sLkDFSSsKRMNTGE Sec1 X +PRKCA PKCA P17252 human CYP2E1 1571 P05181 CYP2E1 human T131 23940009 DIRRFsLttLRNYGM p450 X +PRKCA PKCA P17252 human PDLIM2 213019 Q8R1G6 Pdlim2 mouse S137 4763817 PRPCsPFstPPPtsP X X +PRKCA PKCA P17252 human DLG1 1739 Q12959 DLG1 human T657 22496705 KERARLKtVkFNsKT X +PRKCA PKCA P17252 human lamin A/C 16905 P48678 Lmna mouse S575 1207201 RGsHCsGsGDPAEYN X +PRKCA PKCA P17252 human CHAT iso3 1103 P28329-3 CHAT human S346 454035 LLKHVTQssRKLIRA Carn_acyltransf X +PRKCA PKCA P17252 human CFTR 1080 P13569 CFTR human S795 449982 TAsTRKVsLAPQANL CFTR_R X +PRKCA PKCA P17252 human KCNMA1 282573 Q28204 KCNMA1 cow S1151 14364501 NRQNRPKsRESRDKQ X +PRKCA PKCA P17252 human H3 8350 P68431 H3C1 human T6 13321500 __ArtkQtArkstGG Histone X +PRKCA PKCA P17252 human CK1D 1453 P48730 CSNK1D human S191 1871153002 THLGIEQsRRDDLES Pkinase X +PRKCA PKCA P17252 human SCN9A iso3 6335 Q15858-3 SCN9A human I848 1871432202 LNMLIKIiGNSVGAL Ion_trans X +PRKCA PKCA P17252 human EGLN2 112398 Q96KS0 EGLN2 human S234 4213802 QRAIPPRsIRGDQIA X +PRKCA PKCA P17252 human AID 11628 Q9WVE0 Aicda mouse T140 6835300 GVQIGIMtFKDYFYC APOBEC2 X +PRKCA PKCA P17252 human CD44 960 P16070 CD44 human S672 455524 AVCIAVNsRRRCGQK X +PRKCA PKCA P17252 human CYP3A4 1576 P08684 CYP3A4 human T103 22553306 KECYsVFtNRRPFGP p450 X +PRKCA PKCA P17252 human HABP4 22927 Q5JVS0 HABP4 human T375 11380903 GRGARGGtRGGRGRI IHABP4_N X +PRKCA PKCA P17252 human KCNJ8 25472 Q63664 Kcnj8 rat S397 471151 NsMRRSNsIRRNNSS X +PRKCA PKCA P17252 human GluR1 50592 P19490 Gria1 rat S836 467226 CYkSRSEskRMkGFC X X +PRKCA PKCA P17252 human PRKD2 25865 Q9BZL6 PRKD2 human S876 448800 QGLAERIsVL_____ X +PRKCA PKCA P17252 human TXN 7295 P10599 TXN human T100 457590 NkEkLEAtINELV__ Thioredoxin X +PRKCA PKCA P17252 human ASIC3 286920 O35240 Asic3 rat S523 12518703 VTKTLSAsHRTCYLV X +PRKCA PKCA P17252 human GSTA4 2941 O15217 GSTA4 human T193 455667 VKLsNIPtIKRFLEP GST_C_3 X +PRKCA PKCA P17252 human TNNT2 7139 P45379 TNNT2 human S189 4708251 ARKKKALsNMMHFGG Troponin X +PRKCA PKCA P17252 human PPP1R14B 26472 Q96C90 PPP1R14B human T57 1904503 VRRQGKVtVkYDRKE PP1_inhibitor X +PRKCA PKCA P17252 human PLCB1 P10894 PLCB1 cow S887 450172 HSQPAPGsVKAPAKT X +PRKCA PKCA P17252 human kindlin-3 83706 Q86UX7 FERMT3 human S484 15424197 LSLQRtGsGGPGNHP FERM_M X +PRKCA PKCA P17252 human TRPV5 56302 Q9NQA5 TRPV5 human S654 470109 yVEVFKNsDKEDDQE X +PRKCA PKCA P17252 human VTN 7448 P04004 VTN human S381 452175 RNRKGYRsQRGHsRG X +PRKCA PKCA P17252 human PLM 476487 P56513 FXYD1 dog T89 455220 SsIRRLstRRR____ X +PRKCA PKCA P17252 human p300 2033 Q09472 EP300 human S89 447592 SELLRSGsSPNLNMG X +PRKCA PKCA P17252 human IKKB 3551 O14920 IKBKB human S177 447492 AkELDQGsLCtsFVG Pkinase X 2078; 2697; 2694; 14938; 92255; 36516; 36214 +PRKCA PKCA P17252 human ICOSLG 23308 O75144 ICOSLG human S285 33625706 RDRCLQHsYAGAWAV X +PRKCA PKCA P17252 human TUBA1C 84790 Q9BQE3 TUBA1C human S158 4710870 sLLMERLsVDyGkks Tubulin X +PRKCA PKCA P17252 human C5aR 728 P21730 C5AR1 human S317 450056 RLRKsLPsLLRNVLt X +PRKCA PKCA P17252 human IL2RA 3559 P01589 IL2RA human T271 455370 RQRKsRRtI______ X X +PRKCA PKCA P17252 human CYP2E1 1571 P05181 CYP2E1 human T432 23940011 DYFkPFstGkRVCAG p450 X +PRKCA PKCA P17252 human SCN2A 24766 P04775 Scn2a rat S1506 2999207 NAMKKLGsKKPQKPI X +PRKCA PKCA P17252 human CK1D 1453 P48730 CSNK1D human T176 1868926302 ENkNLtGtARYAsIN Pkinase X X +PRKCA PKCA P17252 human TNNT2 21956 P50752 Tnnt2 mouse S211 451755 QAQtERKsGKRQtER Troponin X +PRKCA PKCA P17252 human pleckstrin 5341 P08567 PLEK human S113 451305 GQKFARKstRRsIRL X X +PRKCA PKCA P17252 human ADRA1D 146 P25100 ADRA1D human S518 1346843000 RAKVssLsHKIRAGG X +PRKCA PKCA P17252 human ICLN 403971 P35521 CLNS1A dog S45 456841 YIAESRLsWLDGSGL Voldacs X +PRKCA PKCA P17252 human DOCK8 81704 Q8NF50 DOCK8 human S2077 3929061 KPIFRVEsQKRDsFH X +PRKCA PKCA P17252 human HDAC5 10014 Q9UQL6 HDAC5 human S259 447995 FPLRkTAsEPNLKVR X 3443 +PRKCA PKCA P17252 human GPR120 iso1 338557 Q5NUL3-1 FFAR4 human T363 31014807 PEKGAILtDtsVKRN X +PRKCA PKCA P17252 human SHOC2 8036 Q9UQ13 SHOC2 human T71 34669125 VAFSVDNtIKRPNPA X +PRKCA PKCA P17252 human calcyon 192349 P58821 Caly rat S169 25687501 MPAIWGNsYRAGKEE Calcyon X +PRKCA PKCA P17252 human MBP 618684 P02687 MBP cow S7 451831 _AAQKRPsQRsKYLA X +PRKCA PKCA P17252 human TRPM4 54795 Q8TD43 TRPM4 human S1145 12559511 RDKRESDsERLKRTs X +PRKCA PKCA P17252 human Vimentin 7431 P08670 VIM human S7 455449 _MStrsVssssyrrM Filament_head X +PRKCA PKCA P17252 human Ku70 2547 P12956 XRCC6 human S78 1875071708 YISKIIssDRDLLAV Ku_N X X +PRKCA PKCA P17252 human IREB1 48 P21399 ACO1 human S138 451387 DFNRRADsLQkNQDL Aconitase X +PRKCA PKCA P17252 human H2B 3018 P33778 H2BC3 human S32 447801 DGKkRKRsRkEsysI Histone X +PRKCA PKCA P17252 human MYBPC1 iso2 109272 G0YZM8 Mybpc1 mouse S83 21560212 QNANSQLstLFVEKP X +PRKCA PKCA P17252 human PPP1CA 100009298 P62139 PPP1CA rabbit S325 452050 PItPPRNsAKAKK__ X +PRKCA PKCA P17252 human CYP2E1 1571 P05181 CYP2E1 human S145 23940000 MGKQGNEsRIQREAH p450 X +PRKCA PKCA P17252 human AHR 196 P35869 AHR human S36 451413 EGIkSNPsKRHRDRL HLH X +PRKCA PKCA P17252 human hnRNP A1 29578 P04256 Hnrnpa1 rat S192 456539 EMASASSsQRGRsGs X +PRKCA PKCA P17252 human IRS1 25467 P35570 Irs1 rat S307 447558 TEsITATsPASMVGG X 2381 +PRKCA PKCA P17252 human GPSM2 76123 Q8VDU0 Gpsm2 mouse S408 4766076 AKLGRRHsMENLELM X +PRKCA PKCA P17252 human PKCE 5581 Q02156 PRKCE human S368 2085101 NNIRKALsFDNRGEE X +PRKCA PKCA P17252 human MARCKS 4082 P29966 MARCKS human S170 451837 sFkLsGFsFkKNKkE MARCKS X +PRKCA PKCA P17252 human CD3G 917 P09693 CD3G human S148 451430 GVRQsRAsDkQTLLP X +PRKCA PKCA P17252 human GJA1 24392 P08050 Gja1 rat S373 459209 RAssRAssRPRPDDL X +PRKCA PKCA P17252 human p47phox 653361 P14598 NCF1 human S303 449405 RGAPPRRssIRNAHs NECFESHC X +PRKCA PKCA P17252 human GPR120 iso1 338557 Q5NUL3-1 FFAR4 human S373 31014806 sVKRNDLsIIsG___ X +PRKCA PKCA P17252 human IREM-1 146722 Q8TDQ1 CD300LF human T221 1868016201 GTsPQKAtTKLSSAQ SIT X +PRKCA PKCA P17252 human IKKB 3551 O14920 IKBKB human S181 447489 DQGsLCtsFVGTLQy Pkinase X 2697; 2694; 14938; 92255; 36516; 36214 +PRKCA PKCA P17252 human ILK 3611 Q13418 ILK human T181 6191018 RTRPRNGtLNkHsGI X +PRKCA PKCA P17252 human NR2C1 22025 Q505F1 Nr2c1 mouse S461 456551 MSPERRKsLMEHIFK Hormone_recep X +PRKCA PKCA P17252 human FMIP 8563 Q13769 THOC5 human S5 453432 ___MSSEssKKRKPK X X +PRKCA PKCA P17252 human F3 2152 P13726 F3 human S285 451611 RKAGVGQsWkENsPL X +PRKCA PKCA P17252 human TAGLN2 8407 P37802 TAGLN2 human T180 4786351 VIGLQMGtNrGAsQA Calponin X +PRKCA PKCA P17252 human PTGIR 5739 P43119 PTGIR human S328 450985 TPLSQLAsGRRDPRA X +PRKCA PKCA P17252 human TAGLN2 8407 P37802 TAGLN2 human S11 27462345 rGPAyGLsREVQQkI X +PRKCA PKCA P17252 human NOXO1 iso3 124056 Q8NFA2-3 NOXO1 human S154 27454492 SRAAGRLsIHSLEAQ X X +PRKCA PKCA P17252 human ANXA2 12306 P07356 Anxa2 mouse S26 450879 tPPsAyGsVKPytNF X +PRKCA PKCA P17252 human MOR-1 25601 P33535 Oprm1 rat S363 447783 stIEQQNsTRVRQNt X +PRKCA PKCA P17252 human ILK 3611 Q13418 ILK human T173 479406 DTFWkGttRTRPRNG X X +PRKCA PKCA P17252 human CYP3A4 1576 P08684 CYP3A4 human S259 22553301 SVKRMKEsRLEDtQK p450 X +PRKCA PKCA P17252 human GSTP1 2950 P09211 GSTP1 human S185 455118 SAYVGRLsARPkLkA GST_C_3 X X +PRKCA PKCA P17252 human PRKD1 5587 Q15139 PRKD1 human S742 448590 GEksFRRsVVGtPAy Pkinase X X +PRKCA PKCA P17252 human HABP4 22927 Q5JVS0 HABP4 human T354 11380902 RKPANDItSQLEINF IHABP4_N X +PRKCA PKCA P17252 human CACNA1C 100101555 P15381 CACB rabbit S1674 480102 QGLVGKPsQRNALSL X +PRKCA PKCA P17252 human PLCB3 5331 Q01970 PLCB3 human S1105 448448 LDRKRHNsIsEAKMR PLC-beta_C X X 2484 +PRKCA PKCA P17252 human EPB41 iso4 2035 P11171-4 EPB41 human S331 451158 RTASKRAsRSLDGAA FA X +PRKCA PKCA P17252 human CD5 921 P06127 CD5 human T436 450130 FHRNHtAtVRsHAEN X +PRKCA PKCA P17252 human RhoGDI alpha 192662 Q99PT1 Arhgdia mouse S96 486318 DLTGDLEsFkkQsFV Rho_GDI X +PRKCA PKCA P17252 human TAGLN 6876 Q01995 TAGLN human S181 469978 VIGLQMGsNrGAsQA Calponin X +PRKCA PKCA P17252 human PLD2 5338 O14939 PLD2 human S243 456497 RWLVVKDsFLLYMCL X +PRKCA PKCA P17252 human MARCKS 613548 P12624 MARCKS cow S158 447786 KKKKKRFsFKKsFKL MARCKS X 11992 +PRKCA PKCA P17252 human CYBA 1535 P13498 CYBA human T147 7103047 ERPQIGGtIkQPPsN Cytochrom_B558a X +PRKCA PKCA P17252 human SUN1 23353 O94901 SUN1 human S55 179463700 sPRMsRRsLRLATTA X +PRKCA PKCA P17252 human IRS1 25467 P35570 Irs1 rat S24 455604 GYLRKPKsMHKRFFV PH X +PRKCA PKCA P17252 human MBP 618684 P02687 MBP cow S45 10306407 SLGRFFGsDRGAPKR Myelin_MBP X +PRKCA PKCA P17252 human SLC29A1 63959 Q9JIM1 Slc29a1 mouse T276 21326705 PGPNsPPtNRNQsIK Nucleoside_tran X +PRKCA PKCA P17252 human ADD1 118 P35611 ADD1 human S716 449828 GsPGKsPsKKKKKFR X +PRKCA PKCA P17252 human PLCB1 24654 P10687 Plcb1 rat S887 450172 HSQPAPGsVKAPAKT X X +PRKCA PKCA P17252 human CFTR 1080 P13569 CFTR human S641 2907508 QNLQPDFsSKLMGCD CFTR_R X +PRKCA PKCA P17252 human RASSF1 iso2 11186 Q9NS23-2 RASSF1 human S203 484000 TsVRRRtsFYLPKDA RA X X +PRKCA PKCA P17252 human rabphilin 3A 171039 P47709 Rph3a rat S274 455801 QGLRRANsVQASRPA X +PRKCA PKCA P17252 human p47phox 653361 P14598 NCF1 human S359 451729 EERQtQRsKPQPAVP p47_phox_C X +PRKCA PKCA P17252 human VASP 7408 P50552 VASP human S157 448379 EHIERRVsNAGGPPA X 3111; 84519 +PRKCA PKCA P17252 human CYP2E1 1571 P05181 CYP2E1 human T376 23940013 PHEAtRDtIFrGYLI p450 X +PRKCA PKCA P17252 human myogenin 17928 P12979 Myog mouse T87 451161 VDRRRAAtLREKRRL HLH X +PRKCA PKCA P17252 human Titin 7273 Q8WZ42 TTN human S11878 10029600 KEEVVLKsVLRKRPE X +PRKCA PKCA P17252 human Caldesmon 100009077 Q28708 CALD1 rabbit S529 448466 QSVDKVTsPTKV___ X +PRKCA PKCA P17252 human BKR2 624 P30411 BDKRB2 human S373 447664 sMGTLRTsIsVERQI X +PRKCA PKCA P17252 human HOXA9 15405 P09631 Hoxa9 mouse S204 2906100 ANWLHARstRKKRCP X +PRKCA PKCA P17252 human TRPV5 Q9XSM3 Trpv5 rabbit S299 470108 FLELVVSsKKREARQ X +PRKCA PKCA P17252 human NPHS1 4868 O60500 NPHS1 human T1120 18507016 EYEESQWtGERDtQS X X +PRKCA PKCA P17252 human NFL 100521224 P02547 NEFL pig S34 457198 SsVRSGYsTARSAYS Filament_head X +PRKCA PKCA P17252 human SCN5A 6331 Q14524 SCN5A human S1503 9993604 NAMKKLGsKKPQKPI X +PRKCA PKCA P17252 human CFTR 1080 P13569 CFTR human S813 449983 DIYsRRLsQEtGLEI CFTR_R X +PRKCA PKCA P17252 human HMGA1 117062 Q8K585 Hmga1 rat S64 3136103 PRGRPKGsKNKGTAK X +PRKCA PKCA P17252 human NMNAT1 64802 Q9HAN9 NMNAT1 human S136 478388 WTETQDSsQKKSLEP CTP_transf_like X +PRKCA PKCA P17252 human CACNA1C 100101555 P15381 CACB rabbit S1517 460572 DYLTRDWsILGPHHL Ion_trans X +PRKCA PKCA P17252 human TNNT2 21956 P50752 Tnnt2 mouse T297 451557 TRGKAKVtGRWK___ Troponin X +PRKCA PKCA P17252 human FMIP 8563 Q13769 THOC5 human S6 453433 __MSSEssKKRKPKV X X +PRKCA PKCA P17252 human NFL 100521224 P02547 NEFL pig S52 457199 APVSSSLsVRRSYSS Filament_head X +PRKCA PKCA P17252 human CYP2E1 1571 P05181 CYP2E1 human T121 23940007 IIFNNGPtWKDIRRF p450 X +PRKCA PKCA P17252 human GluR1 2890 P42261 GRIA1 human S834 9486201 EFcYKsRsEsKRMKG X +PRKCA PKCA P17252 human DRD2 1813 P14416 DRD2 human S229 487433 RVNtkRssRAFRAHL 7tm_1 X +PRKCA PKCA P17252 human TNNI3 7137 P19429 TNNI3 human S24 448424 APIRRRssNyRAyAt Troponin-I_N X 4004 +PRKCA PKCA P17252 human RALBP1 10928 Q15311 RALBP1 human T297 3136101 ACGRTTEtEkVQEFQ RhoGAP X +PRKCA PKCA P17252 human DTNB 1838 O60941 DTNB human T69 27100602 FRDNGLNtLDHTTEI EF-hand_2 X +PRKCA PKCA P17252 human GluR6 54257 P42260 Grik2 rat S868 478417 MVEELRMsLKCQRRL X +PRKCA PKCA P17252 human IGFBP1 3484 P08833 IGFBP1 human S194 451660 LAKAQETsGEEIsKF Thyroglobulin_1 X +PRKCA PKCA P17252 human GPR15 2838 P49685 GPR15 human S357 125971702 FARRRKRsVsL____ X +PRKCA PKCA P17252 human DRD2 1813 P14416 DRD2 human S228 487432 kRVNtkRssRAFRAH 7tm_1 X +PRKCA PKCA P17252 human Met 4233 P08581 MET human S985 450188 PHLDRLVsARsVsPt X +PRKCA PKCA P17252 human GluR1 2890 P42261 GRIA1 human S849 448565 FCLIPQQsINEAIRT X X 75574 +PRKCA PKCA P17252 human TWIST1 7291 Q15672 TWIST1 human S144 41455181 tLPSDkLskIQTLkL HLH X +PRKCA PKCA P17252 human Tau iso8 4137 P10636-8 MAPT human S305 487457 kHVPGGGsVQIVykP Tubulin-binding X +PRKCA PKCA P17252 human GluR2 29627 P19491 Gria2 rat S880 448351 yNVyGIEsVkI____ X +PRKCA PKCA P17252 human Kv1.5 3741 P22460 KCNA5 human T15 465994 LENGGAMtVRGGDEA X +PRKCA PKCA P17252 human PPAR-alpha 25747 P37230 Ppara rat S179 457549 RFGRMPRsEKAKLKA X +PRKCA PKCA P17252 human Akt1 207 P31749 AKT1 human T308 447856 kDGAtMKtFCGtPEy Pkinase X 5106; 2965; 9275; 4056; 5056; 13842; 13038; 43506; 48646; 86758; 80722; 77440; 80556 +PRKCA PKCA P17252 human ITGB4 3691 P16144 ITGB4 human S1494 465821 tLtRDyNsLtRsEHs X X +MAP4K2 GCK Q12851 human LATS1 9113 O95835 LATS1 human T1079 457595 EHAFyEFtFRRFFDD X 8654 +MAP4K2 GCK Q12851 human PSMD2 5708 Q13200 PSMD2 human S361 487471 ENNrFGGsGsQVDsA X +MAP4K2 GCK Q12851 human PRH 5555 P02810 PRH2 human S24 451070 QDLDEDVsQEDVPLV Pro-rich X +MAP4K2 GCK Q12851 human Huntingtin 3064 P42858 HTT human T3 10206804 _____MAtLEkLMkA X X +plk1 PLK1 P70032 frog MASTL 84930 Q96GX5 MASTL human S875 3209091 tAQHLtVsGFsL___ X +plk1 PLK1 P70032 frog MASTL 84930 Q96GX5 MASTL human T860 58984001 QPDDETDtSYFEARN X +plk1 PLK1 P70032 frog MASTL 84930 Q96GX5 MASTL human T75 58984000 DMINkNMtHQVQAER Pkinase X +plk1 PLK1 P70032 frog MASTL 84930 Q96GX5 MASTL human S597 58984002 SDRSIKEssFEESNI X +plk1 PLK1 P70032 frog MASTL 84930 Q96GX5 MASTL human S598 15412079 DRSIKEssFEESNIE X +plk1 PLK1 P70032 frog MASTL 84930 Q96GX5 MASTL human T873 57812701 RNtAQHLtVsGFsL_ X +plk1 PLK1 P70032 frog MASTL 84930 Q96GX5 MASTL human S512 3209079 NkENIVNsFtDkQQt X +plk1 PLK1 P70032 frog MASTL 84930 Q96GX5 MASTL human S552 3209082 KRDYLsssFLCsDDD X +STK26 MST4 Q9P289 human Ezrin 7430 P15311 EZR human T567 448104 QGRDkyKtLRQIRQG ERM_C X X 3141; 3726; 32600 +STK26 MST4 Q9P289 human YAP1 10413 P46937 YAP1 human S94 3253276 RLRkLPDsFFkPPEP X +STK26 MST4 Q9P289 human AMPKA1 5562 Q13131 PRKAA1 human T183 448786 sDGEFLRtsCGsPNy Pkinase X 2535; 2531; 4188; 5256; 50081; 74281 +STK26 MST4 Q9P289 human KEPI 81706 Q8TAE6 PPP1R14C human T73 10296602 RHQQGKVtVkYDRKE PP1_inhibitor X +STK26 MST4 Q9P289 human YAP1 10413 P46937 YAP1 human T83 27460703 ktANVPQtVPMRLRk X X +STK26 MST4 Q9P289 human DDEFL1 55616 Q8TDY4 ASAP3 human T545 181213000 HRFARRCtPEPQRLW X +STK26 MST4 Q9P289 human TRAF6 22034 P70196 Traf6 mouse T494 34362608 LEALRQGtFIKDDTL X +STK26 MST4 Q9P289 human YAP1 10413 P46937 YAP1 human T77 126835301 NAVMNPktANVPQtV X +STK26 MST4 Q9P289 human PDCD10 11235 Q9BUL8 PDCD10 human T43 7452901 VNLsAAQtLRAAFIk DUF1241 X +STK26 MST4 Q9P289 human TRAF6 22034 P70196 Traf6 mouse T471 40240800 LLAFQRPtIPRNPKG X +STK26 MST4 Q9P289 human YAP1 10413 P46937 YAP1 human T41 1868502600 GQPAPAAtQAAPQAP X +STK26 MST4 Q9P289 human QSK 23387 Q9Y2K2 SIK3 human T221 456036 TPGQLLKtWCGSPPY Pkinase X +STK26 MST4 Q9P289 human PDCD10 11235 Q9BUL8 PDCD10 human S39 7452900 ELERVNLsAAQtLRA DUF1241 X +STK26 MST4 Q9P289 human YAP1 10413 P46937 YAP1 human T110 452306 sHsRQAstDAGtAGA X +STK26 MST4 Q9P289 human ATG4B 23192 Q9Y4P1 ATG4B human S383 470896 RLERFFDsEDEDFEI ATG4_LIR X X 19386; 40592 +Aurkb AurB O70126 mouse Vimentin 22352 P20152 Vim mouse S73 449025 sAVRLRssVPGVRLL Filament_head X X +Aurkb AurB O70126 mouse HEC1 67052 Q9D0F1 Ndc80 mouse S55 459763 PTSERKVsIFGKRTs Ndc80_HEC X +Aurkb AurB O70126 mouse Vimentin 22352 P20152 Vim mouse S65 2301100 GGAyVtRssAVRLRs Filament_head X +Aurkb AurB O70126 mouse H3 360198 P68433 H3c1 mouse S10 455676 tkQTARkstGGkAPr Histone X 9701; 9711; 9606; 3465; 3642; 3377; 3475; 3458; 5764; 47398; 8481; 8552; 53348; 29237; 66065; 43185; 64522; 52725 +Aurkb AurB O70126 mouse CASP2 12366 P29594 Casp2 mouse S384 1869992407 MRNTKRGsWYIEALT Peptidase_C14 X +Aurkb AurB O70126 mouse Vimentin 22352 P20152 Vim mouse S87 2301101 LQDsVdFsLADAINT Filament_head X +Aurkb AurB O70126 mouse Vimentin 22352 P20152 Vim mouse S7 455449 _MSTRsVssssYRRM Filament_head X +Aurkb AurB O70126 mouse SGOL2 68549 Q7TSY8 Sgo2a mouse T521 27462598 LSKPSRQtFVIRKSE X +Aurkb AurB O70126 mouse SGOL2 68549 Q7TSY8 Sgo2a mouse T600 89115100 KQKINRRtKIISVMS X +Aurkb AurB O70126 mouse Vimentin 22352 P20152 Vim mouse S25 455453 sGTssRPssNRsYVT Filament_head X +Aurkb AurB O70126 mouse Vimentin 22352 P20152 Vim mouse S39 451766 TTsTRTysLGsALRP Filament_head X 13614 +Aurkb AurB O70126 mouse H3 iso3 15081 P84244 H3f3b mouse S10 455676 tKQTARksTGGkAPR Histone X X 9701; 9711; 9706; 3465; 3642; 3377; 3475; 3458; 5764; 47398; 8481; 8552; 53348; 29237; 66065; 43185; 64522; 52725 +Aurkb AurB O70126 mouse H3 360198 P68433 H3c1 mouse S28 455677 ATkAArksAPATGGV Histone X 9713 +Aurkb AurB O70126 mouse Vimentin 22352 P20152 Vim mouse S66 451765 GAyVtRssAVRLRss Filament_head X +Aurkb AurB O70126 mouse Vimentin 22352 P20152 Vim mouse S47 455455 LGsALRPstsRsLys Filament_head X +Aurkb AurB O70126 mouse K5 110308 Q922U2 Krt5 mouse S31 4769949 tPsVsRTsFssVsRS Keratin_2_head X X +Phkg2 PHKG2 Q9DB30 mouse QSK 23387 Q9Y2K2 SIK3 human S551 468543 GPLGRRAsDGGANIQ X +Phkg2 PHKG2 Q9DB30 mouse QSK 23387 Q9Y2K2 SIK3 human T469 480134 YLSMRRHtVGVADPR X +SRMS SRMS Q9H3Y6 human MKK4 6416 P45985 MAP2K4 human Y307 1881548608 LATGRFPyPKWNSVF X +SRMS SRMS Q9H3Y6 human Brk 5753 Q13882 PTK6 human Y447 450276 RLSSFtsyENPT___ X X +SRMS SRMS Q9H3Y6 human MKK4 6416 P45985 MAP2K4 human Y269 1881548606 RDAGCRPyMAPERID X +SRMS SRMS Q9H3Y6 human FKBP5 2289 Q13451 FKBP5 human Y54 456461 PMIGDKVyVHYKGKL FKBP_C X +SRMS SRMS Q9H3Y6 human SRMS 6725 Q9H3Y6 SRMS human Y380 1873559810 RLLKDDIySPSSSSK PK_Tyr_Ser-Thr X +Stk4 MST1 Q9JI11 mouse IkB-alpha 18035 Q9Z1E3 Nfkbia mouse S32 448203 LVDDRHDsGLDsMKD X 5210; 2859; 9246; 5209 +Stk4 MST1 Q9JI11 mouse IkB-alpha 18035 Q9Z1E3 Nfkbia mouse S36 448204 RHDsGLDsMKDEEYE X 5210; 9246 +Stk4 MST1 Q9JI11 mouse MST1 58231 Q9JI11 Stk4 mouse T387 450050 tMKRRDEtMQPAKPS X +Stk4 MST1 Q9JI11 mouse MST1 58231 Q9JI11 Stk4 mouse T177 450049 VAGQLTDtMAKRNtV Pkinase X +Stk4 MST1 Q9JI11 mouse MST1 58231 Q9JI11 Stk4 mouse T183 447925 DtMAKRNtVIGTPFW Pkinase X 3681; 49332 +Gsk3a GSK3A Q2NL51 mouse YAF2 67057 Q99LW6 Yaf2 mouse S166 3205731 RGVsRsssPRGEAss X +Gsk3a GSK3A Q2NL51 mouse PXN 19303 Q8VI36 Pxn mouse S126 450227 sFPNKQksAEPsPtV Paxillin X +Gsk3a GSK3A Q2NL51 mouse Cbl-b 208650 Q3TTA7 Cblb mouse S476 3823372 KCTDRQNsPVtsPGs X +Gsk3a GSK3A Q2NL51 mouse neurogenin 2 11924 P70447 Neurog2 mouse S231 2255101 SPYSCTLsPAsPGSD X +Gsk3a GSK3A Q2NL51 mouse Cbl-b 208650 Q3TTA7 Cblb mouse S480 4717392 RQNsPVtsPGssPLA X +Gsk3a GSK3A Q2NL51 mouse neurogenin 2 11924 P70447 Neurog2 mouse S234 2255100 SCTLsPAsPGSDVDy X +Gsk3a GSK3A Q2NL51 mouse PPAR-alpha 19013 P23204 Ppara mouse S280 1867858200 FHCCQCMsVETVTEL Hormone_recep X +BRSK1 BRSK1 Q8TDC3 human ERC2 259269 Q8K3M6 Erc2 rat S45 4740442 GGTGKTLsMENIQSL X +BRSK1 BRSK1 Q8TDC3 human Tau iso8 4137 P10636-8 MAPT human S262 447930 NVKskIGstENLkHQ Tubulin-binding X +BRSK1 BRSK1 Q8TDC3 human TUBG1 7283 P23258 TUBG1 human S385 34424909 MANHTSIsSLFERTC Tubulin_C X +BRSK1 BRSK1 Q8TDC3 human Tau iso8 4137 P10636-8 MAPT human S356 449104 rVQskIGsLDNItHV Tubulin-binding X +BRSK1 BRSK1 Q8TDC3 human TUBG1 7283 P23258 TUBG1 human S131 10045600 READGsDsLEGFVLC Tubulin X +HASPIN Haspin Q8TF76 human H3 8350 P68431 H3C1 human T3 455678 _____ArtkQtArks Histone X X 9714; 13576 +HASPIN Haspin Q8TF76 human H3 360198 P68433 H3c1 mouse T3 455678 _____ARtkQTARks Histone X 9714; 13576 +Map2k1 MEK1 P31938 mouse MyoD 17927 P10085 Myod1 mouse Y156 18755302 ILRNAIRyIEGLQAL HLH X +Map2k1 MEK1 P31938 mouse ERK2 26413 P63085 Mapk1 mouse Y185 447594 HtGFLtEyVAtRWYR Pkinase X X 9106; 4370; 4374; 9101; 4375; 4376; 4377; 3510; 5726; 88569; 13214; 13148; 70235; 9488; 89967; 8544; 14196; 14227; 14095; 14474; 75165; 98168; 33370; 54240; 15892; 45899; 55088; 9524; 69217; 48735 +Map2k1 MEK1 P31938 mouse ERK1 26417 Q63844 Mapk3 mouse T203 447542 HDHtGFLtEyVAtRW Pkinase X X 9106; 4370; 4374; 9101; 4375; 4376; 4377; 3510; 5726; 88569; 13214; 13148; 70235; 9488; 89967; 8544; 14196; 14227; 14095; 14474; 75165; 98168; 33370; 54240; 15892; 45899; 55088; 9524; 69217; 48735 +Map2k1 MEK1 P31938 mouse ERK2 26413 P63085 Mapk1 mouse T183 447593 HDHtGFLtEyVAtRW Pkinase X X 9106; 4370; 4374; 9101; 4375; 4376; 4377; 3510; 5726; 88569; 13214; 13148; 70235; 9488; 89967; 8544; 14196; 14227; 14095; 14474; 75165; 98168; 33370; 54240; 15892; 45899; 55088; 9524; 69217; 48735 +Map2k1 MEK1 P31938 mouse ERK1 26417 Q63844 Mapk3 mouse Y205 447543 HtGFLtEyVAtRWyR Pkinase X X 9106; 4370; 4374; 9101; 4375; 4376; 4377; 3510; 5726; 88569; 13214; 13148; 70235; 9488; 89967; 8544; 14196; 14227; 14095; 14474; 75165; 98168; 33370; 54240; 15892; 45899; 55088; 9524; 69217; 48735 +Cdk5 CDK5 Q03114 rat MEF2D 81518 O89038 Mef2d rat S430 449407 SIKSEPVsPSRERSP X X +Cdk5 CDK5 Q03114 rat SYNJ1 iso5 85238 Q62910-5 Synj1 rat S1144 450679 KEFGAPKsPGTARKD X +Cdk5 CDK5 Q03114 rat APP iso4 351 P05067-4 APP human T668 448523 VEVDAAVtPEERHLs APP_amyloid X +Cdk5 CDK5 Q03114 rat HER3 29496 Q62799 Erbb3 rat T871 451841 LLHSEAKtPIKWMAL PK_Tyr_Ser-Thr X X +Cdk5 CDK5 Q03114 rat SEPT5 116728 Q9JJM9 Septin5 rat S327 454379 tQDSRMEsPIPILPL X +Cdk5 CDK5 Q03114 rat Cortactin 60465 A6HYF4 Cttn rat T219 15418706 GFEYQGKtEKHESQk HS1_rep X +Cdk5 CDK5 Q03114 rat MAP2 iso2 25595 P15146-2 Map2 rat S136 448323 ETVNLPPsPPPSPAS X 4541 +Cdk5 CDK5 Q03114 rat NMDAR2A 24409 Q00959 Grin2a rat S1232 448260 sGHFtMRsPFkCDAC NMDAR2_C X X +Cdk5 CDK5 Q03114 rat nestin iso2 25491 P21263-2 Nes rat T1495 449819 GETLPDStPLGLYLR X +Cdk5 CDK5 Q03114 rat SYN3 27204 Q8JZP2 Syn3 mouse S404 482763 VPGATVPsPLRPWGP X +Cdk5 CDK5 Q03114 rat nestin iso2 25491 P21263-2 Nes rat T316 449820 AENSRLQtPGRGSQA X X +Cdk5 CDK5 Q03114 rat nNOS 24598 P29476 Nos1 rat S293 56689901 QSPTKNGsPSRCPRF X +Cdk5 CDK5 Q03114 rat DYN1 140694 P21575 Dnm1 rat S774 450205 SVPAGRRsPTSsPTP X X +Cdk5 CDK5 Q03114 rat FZR1 51343 Q9UM11 FZR1 human S163 4661904 kSQKLLRsPRKPTRK X +Cdk5 CDK5 Q03114 rat Cortactin 60465 A6HYF4 Cttn rat T145 41425400 GFEYQGktEKHASQK HS1_rep X +Cdk5 CDK5 Q03114 rat PKLR iso2 24651 P12928-2 Pklr rat S113 31084572 ATESFATsPLSYRPV PK X +Cdk5 CDK5 Q03114 rat SEPT5 116728 Q9JJM9 Septin5 rat S161 2753800 HCCLYFIsPFGHGLR Septin X +Cdk5 CDK5 Q03114 rat SYNJ1 85238 Q62910 Synj1 rat S1160 450679 REMEAPKsPGTARKD X +Cdk5 CDK5 Q03114 rat HER2 24337 P06494 Erbb2 rat S1176 451842 LERPKTLsPGKNGVV X X +Cdk5 CDK5 Q03114 rat MAP2 25595 P15146 Map2 rat S136 448323 ETVNLPPsPPPsPAS X 4541 +Cdk5 CDK5 Q03114 rat FZR1 51343 Q9UM11 FZR1 human T121 3827860 DRRLQPstPEKkGLF X +Cdk5 CDK5 Q03114 rat KIF11 F1MAB8 Kif11 rat T926 448410 LDIPTGMtPERKNYL Microtub_bind X +Cdk5 CDK5 Q03114 rat JNK3 25272 P49187 Mapk10 rat T131 448033 ISLLNVFtPQKTLEE Pkinase X X +Cdk5 CDK5 Q03114 rat HER3 29496 Q62799 Erbb3 rat S1120 451840 RSRSRSRsPRPRGDS X X +Cdk5 CDK5 Q03114 rat WAVE2 313024 Q5FWU0 Wasf2 rat S137 4258800 PPPLNNLsPYRDDGK X +Cdk5 CDK5 Q03114 rat FZR1 51343 Q9UM11 FZR1 human S40 3215931 PAssPVssPsKHGDR X +Cdk5 CDK5 Q03114 rat TRPV1 83810 O35433 Trpv1 rat T406 473576 IAYSSSEtPNRHDML X X +Cdk5 CDK5 Q03114 rat SYN1 24949 P09951 Syn1 rat S551 448377 ARPPAsPsPQRQAGP X +Cdk5 CDK5 Q03114 rat AP2M1 116563 P84092 Ap2m1 rat S45 2048345 HARQQVRsPVTNIAR Clat_adaptor_s X X +Cdk5 CDK5 Q03114 rat DBN1 81653 Q07266 Dbn1 rat S142 452446 NGLARLSsPVLHRLR X +Cdk5 CDK5 Q03114 rat MAP2 iso3 25595 P15146-3 Map2 rat S136 448323 ETVNLPPsPPPSPAS X 4541 +Cdk5 CDK5 Q03114 rat CDK16 18555 Q04735 Cdk16 mouse S95 453454 tssDEVQsPVRVRMR X +Cdk5 CDK5 Q03114 rat PKAR2B 24679 P12369 Prkar2b rat T69 10941783 GAAAGGGtPsKGVNF X +Cdk5 CDK5 Q03114 rat SOX6 20679 P40645 Sox6 mouse T119 4706790 MNSVTFGtPERRKGs X X +Cdk5 CDK5 Q03114 rat Huntingtin 29424 P51111 Htt rat S1150 465621 LTNPPSLsPIRRKGK X +Cdk5 CDK5 Q03114 rat KIF13B 305967 Q70AM4 Kif13b rat T506 27145806 PEGQVMLtPQKNTRT FHA X +Cdk5 CDK5 Q03114 rat CACNA1D 29716 P27732 Cacna1d rat S1947 1827354811 IGYDsRRsPRRRLLP CAC1F_C X X +Cdk5 CDK5 Q03114 rat TH 25085 P04177 Th rat S31 448544 KQAEAVtsPRFIGRR TOH_N X 3370; 13041 +Cdk5 CDK5 Q03114 rat Huntingtin 29424 P51111 Htt rat S1170 465620 EQTSTPMsPKKGGEA X +Cdk5 CDK5 Q03114 rat PPP1CA 24668 P62138 Ppp1ca rat T320 448686 NPGGRPItPPRNSAK X +Cdk5 CDK5 Q03114 rat DYN1 140694 P21575 Dnm1 rat S778 450206 GRRsPTSsPTPQRRA X X +Cdk5 CDK5 Q03114 rat APP iso2 54226 P08592-2 App rat T668 448523 VEVDAAVtPEERHLS APP_amyloid X X 3823; 6986 +Cdk5 CDK5 Q03114 rat gephyrin 64845 Q03555 Gphn rat S283 2020113 LSttPsEsPRAQAts X X +pYV0001 YpkA YP_068414 bacteria G-alpha(q) 2776 P50148 GNAQ human S53 482964 GTGEsGksTFIKQMR G-alpha X +IKBKB IKKB O14920 human CYLD 1540 Q9NQC7 CYLD human S432 12173909 KMPNTNGsIGHsPLs CYLD_phos_site X X +IKBKB IKKB O14920 human PUMA 27113 Q9BXH1 BBC3 human S106 18610002 LAEQHLEsPVPSAPG PUMA X +IKBKB IKKB O14920 human IkB-alpha 18035 Q9Z1E3 Nfkbia mouse S32 448203 LVDDRHDsGLDsMKD X X 5210; 2859; 9246; 5209 +IKBKB IKKB O14920 human NFkB-p105 4790 P19838 NFKB1 human S923 447769 DELRDSDsVCDsGVE X +IKBKB IKKB O14920 human IKKG 16151 O88522 Ikbkg mouse S375 449755 HsFHLALsNQRRsPP X +IKBKB IKKB O14920 human IRF3 3661 Q14653 IRF3 human T404 449031 NsHPLsLtsDQYKAY X +IKBKB IKKB O14920 human IKKB 16150 O88351 Ikbkb mouse S181 447489 DQGsLCTsFVGTLQy Pkinase X 2697; 2694; 14938; 92255; 36516; 36214 +IKBKB IKKB O14920 human Fos 2353 P01100 FOS human S308 7388000 ADWEPLHsGSLGMGP X +IKBKB IKKB O14920 human TNFAIP3 21929 Q60769 Tnfaip3 mouse S381 487535 EPSTPQLsLMDIKCE X +IKBKB IKKB O14920 human COPS5 10987 Q92905 COPS5 human S201 1827354807 kPPDEGPsEyQtIPL X X +IKBKB IKKB O14920 human p63 8626 Q9H3D4 TP63 human S43 27937107 yRSTMSQsTQtNEFL X +IKBKB IKKB O14920 human TSC1 7248 Q92574 TSC1 human S487 5277800 AAIsRELsEItTAEA Hamartin X X +IKBKB IKKB O14920 human Bcl-10 8915 O95999 BCL10 human S138 470125 NNLsRsNsDEsNFsE X X +IKBKB IKKB O14920 human TNF-R1 7132 P19438 TNFRSF1A human S381 20831307 FVRRLGLsDHEIDRL Death X X +IKBKB IKKB O14920 human CYLD 1540 Q9NQC7 CYLD human S439 12173911 sIGHsPLsLsAQsVM CYLD_phos_site X X +IKBKB IKKB O14920 human PUMA 27113 Q9BXH1 BBC3 human S96 18610001 RPDGPQPsLSLAEQH PUMA X +IKBKB IKKB O14920 human TNFAIP3 7128 P21580 TNFAIP3 human S381 487535 EPsVPQLsLMDVKCE X X 63523 +IKBKB IKKB O14920 human AMPKA1 105787 Q5EG47 Prkaa1 mouse T183 448786 sDGEFLRtsCGsPNY Pkinase X X 2535; 2531; 4188; 5256; 50081; 74281 +IKBKB IKKB O14920 human RAPGEF2 9693 Q9Y4G8 RAPGEF2 human S1254 30995202 GsWTSCSsGsHDNIQ X X +IKBKB IKKB O14920 human MTURN 222166 Q8N3F0 MTURN human S58 149319100 GDNFHVWsESEDCLP DUF4581 X +IKBKB IKKB O14920 human CYLD 1540 Q9NQC7 CYLD human S436 12173907 TNGsIGHsPLsLsAQ CYLD_phos_site X X +IKBKB IKKB O14920 human IRF3 3661 Q14653 IRF3 human S398 449029 VDLHIsNsHPLsLts X +IKBKB IKKB O14920 human MCPIP1 230738 Q5D1E7 Zc3h12a mouse S435 22730005 TSQECLDsGIGsLES X +IKBKB IKKB O14920 human IKKG 8517 Q9Y6K9 IKBKG human S43 449037 PAMLHLPsEQGAPEt X X +IKBKB IKKB O14920 human IKKG 8517 Q9Y6K9 IKBKG human S68 1226900 LRDAIRQsNQILRER NEMO X +IKBKB IKKB O14920 human NFkB-p65 5970 Q04206 RELA human S536 447800 sGDEDFSsIADMDFS X X 4887; 3036; 3031; 4886; 3033; 4025; 5733; 13346; 76778; 31553; 80477; 73992; 87672; 83962 +IKBKB IKKB O14920 human MAVS 57506 Q7Z434 MAVS human S442 58984003 CFEDLAIsASTSLGM X X +IKBKB IKKB O14920 human NFkB-p65 5970 Q04206 RELA human S468 451145 AVFTDLAsVDNsEFQ X X 3039 +IKBKB IKKB O14920 human DOK1 1796 Q99704 DOK1 human S450 454885 sHNsALysQVQKSGA X +IKBKB IKKB O14920 human SNAP23 20619 O09044 Snap23 mouse S95 455262 NRTkNFEsGKNYkAt SNAP-25 X X +IKBKB IKKB O14920 human EDC4 23644 Q6P2E9 EDC4 human S583 4271998 PAPADFLsLssEtKP X +IKBKB IKKB O14920 human Bcl-10 8915 O95999 BCL10 human S136 15402376 AtNNLsRsNsDEsNF X X +IKBKB IKKB O14920 human PFKFB3 5209 Q16875 PFKFB3 human S269 58109402 QGRIGGDsGLSsRGK His_Phos_1 X X +IKBKB IKKB O14920 human Bcl-3 602 P20749 BCL3 human S454 31867760 PsPAPGGs_______ X +IKBKB IKKB O14920 human ASB8 140461 Q9H765 ASB8 human S31 1868140200 RTIAAIRsFPHDNVE Ank_2 X +IKBKB IKKB O14920 human Bcl-10 8915 O95999 BCL10 human S144 15408027 NsDEsNFsEkLRAST X X +IKBKB IKKB O14920 human TSC1 7248 Q92574 TSC1 human S511 3208191 DsPFyRDsLPGsQRK Hamartin X X +IKBKB IKKB O14920 human RPS3 6188 P23396 RPS3 human S209 9765788 kPLPDHVsIVEPkDE X +IKBKB IKKB O14920 human Huntingtin 3064 P42858 HTT human S16 12056100 kAFEsLksFQQQQQQ X X +IKBKB IKKB O14920 human IRF3 3661 Q14653 IRF3 human S402 449030 IsNsHPLsLtsDQYK X +IKBKB IKKB O14920 human IKKB 3551 O14920 IKBKB human S258 31849417 GTVKFsssLPyPNNL Pkinase X X +IKBKB IKKB O14920 human optineurin 10133 Q96CV9 OPTN human S513 21214714 FEDGGRQsLMEMQsR X +IKBKB IKKB O14920 human Myc 4609 P01106 MYC human S82 4967400 PLsPsRRsGLCsPSy Myc_N X +IKBKB IKKB O14920 human COPS5 10987 Q92905 COPS5 human T205 1827354804 EGPsEyQtIPLNkIE X X +IKBKB IKKB O14920 human NFkB-p65 5970 Q04206 RELA human S311 449966 RtyEtFksIMkksPF X +IKBKB IKKB O14920 human IKKG 16151 O88522 Ikbkg mouse S369 448798 LPAPAHHsFHLALsN X +IKBKB IKKB O14920 human NFkB-p65 5970 Q04206 RELA human S42 25302155 RYkCEGRsAGsIPGE RHD_DNA_bind X +IKBKB IKKB O14920 human IkB-alpha 4792 P25963 NFKBIA human S32 448203 LLDDRHDsGLDsMkD X X 5210; 2859; 9246; 5209 +IKBKB IKKB O14920 human IKKG 8517 Q9Y6K9 IKBKG human S85 458399 ELLHFQAsQREEKEF NEMO X +IKBKB IKKB O14920 human FOXO3A 2309 O43524 FOXO3 human S644 451438 GLDFNFDsLISTQNV FOXO-TAD X X +IKBKB IKKB O14920 human REL 5966 Q04864 REL human S557 480318 SNTTVFVsQSDAFEG X +IKBKB IKKB O14920 human IRF5 3663 Q13568 IRF5 human S446 26389901 DsIRLQIsNPDLKDR X X +IKBKB IKKB O14920 human NFkB-p105 4790 P19838 NFKB1 human S927 447770 DSDsVCDsGVETsFR X X +IKBKB IKKB O14920 human Huntingtin 15194 P42859 Htt mouse S13 10206805 kLMkAFEsLksFQQQ X +IKBKB IKKB O14920 human DOK1 1796 Q99704 DOK1 human S446 454884 sGIKsHNsALysQVQ X +IKBKB IKKB O14920 human CYLD 1540 Q9NQC7 CYLD human S441 12173908 GHsPLsLsAQsVMEE CYLD_phos_site X X +IKBKB IKKB O14920 human NFkB-p65 5970 Q04206 RELA human S131 477907 RDLEQAIsQRIQtNN RHD_DNA_bind X +IKBKB IKKB O14920 human Myc 4609 P01106 MYC human S86 449991 sRRsGLCsPSyVAVt Myc_N X +IKBKB IKKB O14920 human NFkB-p65 5970 Q04206 RELA human S45 25302163 CEGRsAGsIPGERST RHD_DNA_bind X +IKBKB IKKB O14920 human KIF2A iso1 16563 P28740-1 Kif2a mouse S456 23119260 EGAEINKsLLALKEC Kinesin X +IKBKB IKKB O14920 human p73 7161 O15350 TP73 human S471 18944909 GEMSSSHsAQSMVSG X X +IKBKB IKKB O14920 human p63 8626 Q9H3D4 TP63 human S51 28802100 TQtNEFLsPEVFQHI X +IKBKB IKKB O14920 human IkB-alpha 18035 Q9Z1E3 Nfkbia mouse S36 448204 RHDsGLDsMKDEEYE X X 5210; 9246 +IKBKB IKKB O14920 human NFkB-p65 5970 Q04206 RELA human S261 56850201 tPPYADPsLQAPVRV RHD_dimer X +IKBKB IKKB O14920 human DOK1 1796 Q99704 DOK1 human S439 454882 EPGtATGsGIKsHNs X +IKBKB IKKB O14920 human IkB-alpha 4792 P25963 NFKBIA human S36 448204 RHDsGLDsMkDEEyE X X 5210; 9246 +IKBKB IKKB O14920 human NKX3-2 12020 P97503 Nkx3-2 mouse S148 20473603 EAPVRsDsEMSASVS X +IKBKB IKKB O14920 human RELB 5971 Q01201 RELB human S472 36392502 DFFSGTVsLPGLEPP RelB_transactiv X X +IKBKB IKKB O14920 human IGPR-1 126259 Q96BF3 TMIGD2 human S220 14160579 GKDQRGQsIyStSFP X X +IKBKB IKKB O14920 human NFkB-p105 4790 P19838 NFKB1 human S80 1869465801 sSEKNKKsYPQVKIC RHD_DNA_bind X X +IKBKB IKKB O14920 human Huntingtin 3064 P42858 HTT human S13 10206805 kLMkAFEsLksFQQQ X X +IKBKB IKKB O14920 human EDC4 23644 Q6P2E9 EDC4 human S855 56660920 GLQEKHKsLAFHRPP X +IKBKB IKKB O14920 human p16-INK4A 1029 P42771 CDKN2A human S8 448830 MEPAAGssMEPSADW X X +IKBKB IKKB O14920 human IRF3 3661 Q14653 IRF3 human S396 449028 NtVDLHIsNsHPLsL X 4947; 29047; 83611; 10327; 53539; 81093; 52270; 61166 +IKBKB IKKB O14920 human IKKG 8517 Q9Y6K9 IKBKG human S31 449036 QDVLGEEsPLGKPAM X +IKBKB IKKB O14920 human CYLD 1540 Q9NQC7 CYLD human S568 1874990002 LAFGGYLsEVVEENT X +IKBKB IKKB O14920 human EDC4 23644 Q6P2E9 EDC4 human S107 23101593 IVASsDssISskARG X +IKBKB IKKB O14920 human MCPIP1 230738 Q5D1E7 Zc3h12a mouse S439 22730006 CLDsGIGsLESQMSE X +IKBKB IKKB O14920 human NKX3-2 12020 P97503 Nkx3-2 mouse S146 20473604 EEEAPVRsDsEMSAS X +IKBKB IKKB O14920 human NFkB-p65 19697 Q04207 Rela mouse S545 25302159 MDFSALLsQISS___ X +IKBKB IKKB O14920 human FOXO1A 2308 Q12778 FOXO1 human S319 449113 TFRPRtssNAstIsG X X 2486 +IKBKB IKKB O14920 human STAT1 6772 P42224 STAT1 human T749 56654462 EFDsMMNtV______ X +IKBKB IKKB O14920 human NKX3-2 12020 P97503 Nkx3-2 mouse S168 20473602 RGEDDSVsPGGARVP X +IKBKB IKKB O14920 human CYLD 74256 Q80TQ2 Cyld mouse S414 4745557 SSENRFHsLPFsLtK CYLD_phos_site X +IKBKB IKKB O14920 human CYLD 1540 Q9NQC7 CYLD human S444 12173910 PLsLsAQsVMEELNT CYLD_phos_site X X +IKBKB IKKB O14920 human CYLD 1540 Q9NQC7 CYLD human S422 4745563 RFHsLPFsLtKMPNT CYLD_phos_site X X +IKBKB IKKB O14920 human AMPKA1 105787 Q5EG47 Prkaa1 mouse S184 3195152 DGEFLRtsCGsPNYA Pkinase X +IKBKB IKKB O14920 human PUMA 27113 Q9BXH1 BBC3 human S10 18610000 RARQEGSsPEPVEGL PUMA X +IKBKB IKKB O14920 human HSC70 15481 P63017 Hspa8 mouse S85 31857927 FDDAVVQsDMkHWPF HSP70 X X +IKBKB IKKB O14920 human SNAP23 20619 O09044 Snap23 mouse S120 455263 NVVskQPsRITNGQP SNAP-25 X X +IKBKB IKKB O14920 human EDC4 23644 Q6P2E9 EDC4 human S405 1337911000 PDIFSSVsVPPSLKV Ge1_WD40 X +IKBKB IKKB O14920 human Bcl-10 8915 O95999 BCL10 human S141 4786673 sRsNsDEsNFsEkLR X X +IKBKB IKKB O14920 human IRS1 3667 P35568 IRS1 human S312 447558 tEsItAtsPAsMVGG X 2381 +IKBKB IKKB O14920 human IKKB 3551 O14920 IKBKB human S177 447492 AkELDQGsLCtsFVG Pkinase X X 2078; 2697; 2694; 14938; 92255; 36516; 36214 +IKBKB IKKB O14920 human NFkB-p65 19697 Q04207 Rela mouse S534 447800 sGDEDFssIADMDFS X X 4887; 3036; 3031; 4886; 3033; 4025; 5733; 13346; 76778; 31553; 80477; 73992; 87672; 83962 +IKBKB IKKB O14920 human AMPKA1 105787 Q5EG47 Prkaa1 mouse T388 7712505 EtPRARHtLDELNPQ X +IKBKB IKKB O14920 human IKKB 3551 O14920 IKBKB human S181 447489 DQGsLCtsFVGTLQy Pkinase X X 2697; 2694; 14938; 92255; 36516; 36214 +IKBKB IKKB O14920 human PIK3R1 18708 P26450 Pik3r1 mouse S690 25018700 EPYNLYSsLKELVLH SH2 X +IKBKB IKKB O14920 human NFkB-p65 19697 Q04207 Rela mouse S467 451145 GVFTDLAsVDNSEFQ X 3039 +IKBKB IKKB O14920 human IKKG 8517 Q9Y6K9 IKBKG human S376 448798 PPAPAyLssPLALPs X 2689 +IKBKB IKKB O14920 human CYLD 1540 Q9NQC7 CYLD human S418 4745557 TTENRFHsLPFsLtK CYLD_phos_site X X 4500 +IKBKB IKKB O14920 human NFkB-p105 4790 P19838 NFKB1 human S932 447771 CDsGVETsFRKLsFt X 4806; 4808; 41317 +IKBKB IKKB O14920 human Huntingtin 3064 P42858 HTT human T3 10206804 _____MAtLEkLMkA X +IKBKB IKKB O14920 human SNAP23 8773 O00161 SNAP23 human S95 455262 NRTkNFEsGkAykTt SNAP-25 X +IKBKB IKKB O14920 human Bcl-10 8915 O95999 BCL10 human S134 467254 DGAtNNLsRsNsDEs X X +IKBKB IKKB O14920 human DOK1 1796 Q99704 DOK1 human S443 454883 ATGsGIKsHNsALys X +IKBKB IKKB O14920 human IRF3 3661 Q14653 IRF3 human S405 449032 sHPLsLtsDQYKAYL X +Prkaca PKACA P27791 rat GSK3B 84027 P18266 Gsk3b rat S9 449111 SGRPRTTsFAESCKP X 9336; 9331; 9327; 9323; 9322; 9325; 5558; 8566; 79774; 8466; 25462; 14026; 14332; 14310; 14630 +Prkaca PKACA P27791 rat mGluR2 24415 P31421 Grm2 rat S843 450654 GSAAPRAsANLGQGS X X +Prkaca PKACA P27791 rat PPP1R1A 58977 P19103 Ppp1r1a rat T35 447759 QIRRRRPtPATLVLT DARPP-32 X +Prkaca PKACA P27791 rat RKIP 29542 P31044 Pebp1 rat S51 3189670 TQVMNRPssIsWDGL PBP X +Prkaca PKACA P27791 rat Merlin 25744 Q63648 Nf2 rat S514 448282 DTDMKRLsMEIEKEK ERM_C X 9163; 13281 +Prkaca PKACA P27791 rat PLCB3 29322 Q99JE6 Plcb3 rat S1105 448448 LDRKRNNsISEAKTR PLC-beta_C X 2484 +Prkaca PKACA P27791 rat phosducin 287007 P19632 PDC cow S73 451205 ERFSRKMsVQEYELI Phosducin X +Prkaca PKACA P27791 rat NHE3 24784 P26433 Slc9a3 rat S552 450899 AEGERRGsLAFIRSP X +Prkaca PKACA P27791 rat Nur77 79240 P22829 Nr4a1 rat S350 447942 GRRGRLPsKPKQPPD X 5095 +Prkaca PKACA P27791 rat RIMS1 84556 Q9JIR4 Rims1 rat S413 450481 ARHERRHsDVALPHT X +Prkaca PKACA P27791 rat GluR6 54257 P42260 Grik2 rat S856 478416 NAQLEKRsFCSAMVE X +Prkaca PKACA P27791 rat GLUT2 25351 P12336 Slc2a2 rat S503 451346 EFRKKsGsAPPRKAt X X +Prkaca PKACA P27791 rat AMPKA1 105787 Q5EG47 Prkaa1 mouse S496 450431 AtPQRsGsIsNYRsC AdenylateSensor X 4185; 4184; 2537 +Prkaca PKACA P27791 rat NFE2L1 4779 Q14494 NFE2L1 human S599 454236 PSALKKGsKEKQADF X +Prkaca PKACA P27791 rat BAD 64639 O35147 Bad rat S156 447863 GRELRRMsDEFEGSF Bcl-2_BAD X +Prkaca PKACA P27791 rat PDE3B 29516 Q63085 Pde3b rat S302 449873 GKMFRRPsLPCISRE X +Prkaca PKACA P27791 rat CBX3 297093 Q5RJK5 Cbx3 rat S93 457001 KDGTKRKsLsDsESD X X +Prkaca PKACA P27791 rat NFL 83613 P19527 Nefl rat S42 457402 TARsAySsySAPVsS Filament_head X +Prkaca PKACA P27791 rat STEP iso3 84867 P54829-3 PTPN5 human S221 448294 GLQERRGsNVSLTLD X X +Prkaca PKACA P27791 rat STMN1 29332 P13668 Stmn1 rat S63 448557 AAEERRKsHEAEVLk Stathmin X +Prkaca PKACA P27791 rat PHKG1 100009297 P00518 PHKG1 rabbit S82 455919 VDILRKVsGHPNIIQ Pkinase X +Prkaca PKACA P27791 rat HSL 25330 P15304 Lipe rat S960 450195 GFHPRRssQGVLHMP Abhydrolase_3 X 4126 +Prkaca PKACA P27791 rat ACC1 60581 P11497 Acaca rat S77 448291 LAFHMRSsMsGLHLV X +Prkaca PKACA P27791 rat rabphilin 3A 171039 P47709 Rph3a rat S234 455904 GPPTRRAsEARMSTT X +Prkaca PKACA P27791 rat KCNN4 65206 Q9QYW1 Kcnn4 rat T327 452144 AWMYYKHtRRKDsRA CaMBD X +Prkaca PKACA P27791 rat IP3R3 3710 Q14573 ITPR3 human S916 468030 GGKNVRRsIQGVGHM X +Prkaca PKACA P27791 rat FBPase 24362 P19112 Fbp1 rat S357 449856 AREsPVHsICDELF_ X +Prkaca PKACA P27791 rat NFL 83613 P19527 Nefl rat S50 457403 ySAPVsSsLSVRRsY Filament_head X +Prkaca PKACA P27791 rat SNAP-25 25012 P60881 Snap25 rat T138 449875 GGFIRRVtNDARENE SNAP-25 X +Prkaca PKACA P27791 rat PIK3R1 282307 P23727 PIK3R1 cow S83 471075 YIGRKKIsPPtPKPR X +Prkaca PKACA P27791 rat NKX2-1 25628 P23441 Nkx2-1 rat T9 451108 SMSPKHTtPFsVSDI X +Prkaca PKACA P27791 rat TP2 24840 P11101 Tnp2 rat S109 450902 HRAkRRSsGRRYK__ TP2 X +Prkaca PKACA P27791 rat mGluR3 24416 P31422 Grm3 rat S845 450252 RLHLNRFsVSGTATT X +Prkaca PKACA P27791 rat GluR4 29629 P19493 Gria4 rat S862 448810 TRNKARLsITGSVGE X +Prkaca PKACA P27791 rat SCN2A 24766 P04775 Scn2a rat S610 451195 DNDSRRDsLFVPHRH Na_trans_cytopl X +Prkaca PKACA P27791 rat PAH 24616 P04176 Pah rat S16 449074 GVLSRKLsDFGQETS X +Prkaca PKACA P27791 rat NFM 24588 P12839 Nefm rat S2 457406 ______MsYTLDSLG X +Prkaca PKACA P27791 rat NFL 83613 P19527 Nefl rat S436 457404 QSSsyLMsARAFPAy X +Prkaca PKACA P27791 rat SCN2A 24766 P04775 Scn2a rat S554 452015 TYEKRFssPHQsLLS X +Prkaca PKACA P27791 rat NFkB-p65 309165 Q7TQN4 Rela rat S276 447798 SMQLRRPsDRELSEP RHD_dimer X +Prkaca PKACA P27791 rat Tau iso8 4137 P10636-8 MAPT human S262 447930 NVKskIGstENLkHQ Tubulin-binding X +Prkaca PKACA P27791 rat FBPase 24362 P19112 Fbp1 rat S342 449869 DKAKsRPsLPLPQSR X +Prkaca PKACA P27791 rat SCN5A 25665 P15389 Scn5a rat S526 451568 TSMRPRSsRGsIFTF Na_trans_cytopl X X +Prkaca PKACA P27791 rat AQP2 25386 P34080 Aqp2 rat S269 3339002 PQsLPRGskA_____ X +Prkaca PKACA P27791 rat HSL 25330 P15304 Lipe rat S863 448803 LTESMRRsVsEAALA X +Prkaca PKACA P27791 rat EEF2K 25435 P70531 Eef2k rat S365 447827 sPRIRTLsGSRPPLL X +Prkaca PKACA P27791 rat SYN1 24949 P09951 Syn1 rat S9 448378 NYLRRRLsDSNFMAN Synapsin_N X 2311; 67605 +Prkaca PKACA P27791 rat AMPKA1 65248 P54645 Prkaa1 rat S496 450431 AtPQRSGsISNYRSC AdenylateSensor X 4185; 4184; 2537 +Prkaca PKACA P27791 rat SYN3 29130 O70441 Syn3 rat S9 449840 NFLRRRLsDSSFVAN Synapsin_N X +Prkaca PKACA P27791 rat DNAJC5 79130 P60905 Dnajc5 rat S10 448129 DQRQRsLsTsGEsLY X X +Prkaca PKACA P27791 rat NFM 24588 P12839 Nefm rat S609 448044 AKsPVPKsPVEEVKP X +Prkaca PKACA P27791 rat Kir5.1 29719 P52191 Kcnj16 rat S417 451508 LNRISMEsQM_____ X +Prkaca PKACA P27791 rat HSL 25330 P15304 Lipe rat S959 450194 DGFHPRRssQGVLHM Abhydrolase_3 X +Prkaca PKACA P27791 rat SLC38A3 252919 Q9JHZ9 Slc38a3 rat S52 19001700 KGFLQQSsSKEPHFT X +Prkaca PKACA P27791 rat CREB iso1 81646 P15337-1 Creb1 rat S133 448228 EILsRRPsYRkILND pKID X X 9187; 9196; 9198; 4095; 14228; 14001; 39561; 80120; 44864; 54960; 95995 +Prkaca PKACA P27791 rat mGluR2 24415 P31421 Grm2 rat S675 452085 AQRPRFIsPASQVAI 7tm_3 X +Prkaca PKACA P27791 rat PDE1A 281969 P14100 PDE1A cow S120 451186 EEKPRFRsIVHVVQA PDEase_I_N X +Prkaca PKACA P27791 rat SCN2A 24766 P04775 Scn2a rat S573 451193 LFsPrRNsRAsLFNF Na_trans_cytopl X +Prkaca PKACA P27791 rat IPO13 116458 Q9JM04 Ipo13 rat S193 15420334 RKGLVRAsLAVECGA Xpo1 X +Prkaca PKACA P27791 rat Myf-6 25714 P19335 Myf6 rat S221 451240 SSLQRLssIVDSISS X +Prkaca PKACA P27791 rat Kv1.4 25469 P15385 Kcna4 rat S229 457537 FFDRNRPsFDAILYY BTB_2 X +Prkaca PKACA P27791 rat DRP1 114114 O35303 Dnm1l rat S656 483971 VPVARKLsAREQRDC X 4867; 6319 +Prkaca PKACA P27791 rat MYPT1 116670 Q10728 Ppp1r12a rat S669 478658 EVRERRRsYLTPVRD X 3048 +Prkaca PKACA P27791 rat KCNN4 65206 Q9QYW1 Kcnn4 rat S312 452143 YAKEMKEsAARLLQE CaMBD X +Prkaca PKACA P27791 rat GHF-1 25517 P10037 Pou1f1 rat T220 451518 RKRKRRTtISIAAKD Homeodomain X +Prkaca PKACA P27791 rat AQP2 25386 P34080 Aqp2 rat S261 464644 RQsVELHsPQsLPRG X +Prkaca PKACA P27791 rat NFL 83613 P19527 Nefl rat S13 457195 YEPYFSTsYkRRYVE Filament_head X +Prkaca PKACA P27791 rat HSP20 192245 P97541 Hspb6 rat S16 450706 PsWLRRAsAPLPGFS Crystallin X 36519 +Prkaca PKACA P27791 rat BAD 64639 O35147 Bad rat S137 447862 PFRGRsRsAPPNLWA Bcl-2_BAD X 9295; 5286; 4366 +Prkaca PKACA P27791 rat SLC14A2 54302 Q62668 Slc14a2 rat S486 2813501 TVFPRRKsVFHIEWS X +Prkaca PKACA P27791 rat THOP1 64517 P24155 Thop1 rat S644 448213 VGMDYRTsILRPGGS Peptidase_M3 X X +Prkaca PKACA P27791 rat LC3B 81631 Q9GZQ8 MAP1LC3B human T6 14150105 __MPSEktFKQRRTF X +Prkaca PKACA P27791 rat Myf-6 25714 P19335 Myf6 rat S220 451239 SSSLQRLssIVDSIS X +Prkaca PKACA P27791 rat PAK1 29431 P35465 Pak1 rat T422 448177 PEQSKRstMVGTPYW Pkinase X +Prkaca PKACA P27791 rat GLUT2 25351 P12336 Slc2a2 rat S489 451344 VPETKGKsFDEIAAE Sugar_tr X X +Prkaca PKACA P27791 rat H3 291159 Q6LED0 Hist1h2ail1 rat S10 455676 tkQTARkstGGkAPR Histone X X 9701; 9711; 9606; 3465; 3642; 3377; 3475; 3458; 5764; 47398; 8481; 8552; 53348; 29237; 66065; 43185; 64522; 52725 +Prkaca PKACA P27791 rat EEF2K 25435 P70531 Eef2k rat S499 455998 RLHLPRPsAVALEVQ X +Prkaca PKACA P27791 rat GluR1 50592 P19490 Gria1 rat S863 448566 TSTLPRNsGAGASGG X 8084 +Prkaca PKACA P27791 rat STEP iso3 84867 P54829-3 PTPN5 human S160 51170600 PPEDRRQsVSRQPSF X X +Prkaca PKACA P27791 rat IP3R3 3710 Q14573 ITPR3 human S934 475070 MVLsRkQsVFsAPsL X +Prkaca PKACA P27791 rat ACC1 60581 P11497 Acaca rat S1200 448290 IPtLNRMsFASNLNH ACC_central X +Prkaca PKACA P27791 rat HSL 25330 P15304 Lipe rat S865 448804 ESMRRsVsEAALAQP X 4137 +Prkaca PKACA P27791 rat NHE3 24784 P26433 Slc9a3 rat S605 450900 SLEQRRRsIRDTEDM X +Prkaca PKACA P27791 rat dynactin 1 29167 P28023 Dctn1 rat S19 455515 TPSGSRMsTEASARP X X +Prkaca PKACA P27791 rat Survivin 332 O15392 BIRC5 human S20 485776 FLkDHRIstFkNWPF BIR X +Prkaca PKACA P27791 rat CYP3A5 25642 P04800 Cyp3a1 rat S393 451172 GVFMPKGsVVMIPSY p450 X +Prkaca PKACA P27791 rat PKD2 5311 Q13563 PKD2 human S801 15702202 SSLPRPMsSRSFPRs X +Prkaca PKACA P27791 rat CAMKK2 83506 O88831 Camkk2 rat T144 15425433 PRMPRRPtVESHHVS X X +Prkaca PKACA P27791 rat GLUT2 25351 P12336 Slc2a2 rat T510 451347 sAPPRKAtVQMEFLG X X +Prkaca PKACA P27791 rat CACNA1C 12288 Q01815 Cacna1c mouse S1897 455278 ASLGRRAsFHLECLK CAC1F_C X +Prkaca PKACA P27791 rat PLM 5348 O00168 FXYD1 human S88 451425 RssIRRLstRRR___ X +Prkaca PKACA P27791 rat IP3R3 3710 Q14573 ITPR3 human S1832 475071 TTkGRVAsFsIPGss X +Prkaca PKACA P27791 rat SCN2A 24766 P04775 Scn2a rat S623 451196 RHGERRPsNVSQASR Na_trans_cytopl X +Prkaca PKACA P27791 rat GATA4 54254 P46152 Gata4 rat S261 450013 IKPQRRLsASRRVGL X +Prkaca PKACA P27791 rat RYR2 689560 B0LPN4 Ryr2 rat S2021 455603 TIRGRLLsLVEKVTY X +Prkaca PKACA P27791 rat Tau iso8 4137 P10636-8 MAPT human S214 447929 GsRsRtPsLPtPPtR X 77348 +Prkaca PKACA P27791 rat PLM 58971 O08589 Fxyd1 rat S88 451425 RSsIRRLstRRR___ X +Prkaca PKACA P27791 rat Nur77 79240 P22829 Nr4a1 rat S340 451513 KEVVRTDsLKGRRGR X +Prkaca PKACA P27791 rat PDE10A iso2 10846 Q9Y233-2 PDE10A human T16 478273 AScFRRLtECFLSPS X +Prkaca PKACA P27791 rat NFM 24588 P12839 Nefm rat S604 451836 EKPEKAKsPVPKsPV X +Prkaca PKACA P27791 rat phosducin 25343 P20942 Pdc rat S73 451205 ERMSRKMsIQEYELI Phosducin X +Prkaca PKACA P27791 rat SHANK3 59312 Q9JLU4 Shank3 rat S685 3844913 PPPKRAPsTTLTLRS X +Prkaca PKACA P27791 rat PKAR2B 24679 P12369 Prkar2b rat S112 452036 NRFTRRAsVCAEAyN X +Prkaca PKACA P27791 rat HMGCR 101843185 P09610 HMGCR hamster S871 448568 SHMVHNRsKINLQDL X +Prkaca PKACA P27791 rat Stargazin 84347 Q71RJ2 Cacng2 rat T321 451273 NTANRRTtPV_____ X X +Prkaca PKACA P27791 rat RYR2 689560 B0LPN4 Ryr2 rat S2798 448848 yNRTRRIsQTsQVsI X +Prkaca PKACA P27791 rat KCNN4 65206 Q9QYW1 Kcnn4 rat T348 452146 KMLAAIHtFRQVRLK CaMBD X +Prkaca PKACA P27791 rat nAChRA7 25302 Q05941 Chrna7 rat S365 451182 QHKPRRCsLASVELS Neur_chan_memb X +Prkaca PKACA P27791 rat ATP1A1 24211 P06685 Atp1a1 rat S943 451649 ICKTRRNsVFQQGMK Cation_ATPase_C X +Prkaca PKACA P27791 rat TH 25085 P04177 Th rat S40 448545 RFIGRRQsLIEDARK TOH_N X X 2791 +Prkaca PKACA P27791 rat CACNA1C 24239 P22002 Cacna1c rat S1927 455278 ASLGRRAsFHLECLK CAC1F_C X +Prkaca PKACA P27791 rat prolactin 24683 P01237 Prl rat S206 451732 IRCLRRDsHKVDNYL Hormone_1 X +Prkaca PKACA P27791 rat eIF2-beta 100009285 P41035 EIF2S2 rabbit S218 454002 RVGTKKTsFVNFTDI eIF-5_eIF-2B X +Prkaca PKACA P27791 rat neurabin 1 84685 O35867 Ppp1r9a rat S461 455523 ANRKIKFsCAPIKVF PDZ_5 X X +Prkaca PKACA P27791 rat HMGCR 25675 P51639 Hmgcr rat S871 448568 SHMVHNRsKINLQDL X +Prkaca PKACA P27791 rat LC3B 81631 Q9GZQ8 MAP1LC3B human T29 14150106 LIREQHPtkIPVIIE ATG8 X +Prkaca PKACA P27791 rat NPPA 24602 P01161 Nppa rat S128 22689700 PRSLRRSsCFGGRID ANP X +Prkaca PKACA P27791 rat Myf-6 25714 P19335 Myf6 rat S89 451238 CKTCKRKsAPTDRRK Basic X +Prkaca PKACA P27791 rat NFM 24588 P12839 Nefm rat S767 451045 VTNGLDVsPAEEKKG X +Prkaca PKACA P27791 rat SCN2A 24766 P04775 Scn2a rat S687 451194 EIRKRRsssyHVsMD Na_trans_cytopl X +Prkaca PKACA P27791 rat EVL 51466 Q9UI08 EVL human S158 11379602 EsLERRTsATGPILP X +Prkaca PKACA P27791 rat SCN5A 25665 P15389 Scn5a rat S529 451569 RPRSsRGsIFTFRRR Na_trans_cytopl X X +Prkaca PKACA P27791 rat SYN2 29179 Q63537 Syn2 rat S10 449839 NFLRRRLsDSSFIAN Synapsin_N X +Prkaca PKACA P27791 rat STMN2 84510 P21818 Stmn2 rat S97 455607 AAEGRRKsQEAQVLK Stathmin X +Prkaca PKACA P27791 rat AQP2 25386 P34080 Aqp2 rat S264 2238600 VELHsPQsLPRGskA X +Prkaca PKACA P27791 rat NFM 24588 P12839 Nefm rat S667 448045 PDKKKAEsPVKEKAV X +Prkaca PKACA P27791 rat CAMKK1 60341 P97756 Camkk1 rat T108 452083 PRAWRRPtIESHHVA X +Prkaca PKACA P27791 rat TP2 24840 P11101 Tnp2 rat T101 450901 AVRRRKRtHRAkRRS TP2 X +Prkaca PKACA P27791 rat Restin 65201 Q9JK25 Clip1 rat S311 4769833 ASLKRsPsAssLSSM X +Prkaca PKACA P27791 rat C/EBP-beta 24253 P21272 Cebpb rat S105 448425 AKPSKKPsDYGyVsL X 3081 +Prkaca PKACA P27791 rat STEP 29644 P35234 Ptpn5 rat S49 448294 GLQERRGsNVSLTLD X X 5659 +Prkaca PKACA P27791 rat SYN1 281510 P17599 SYN1 cow S9 448378 NYLRRRLsDSNFMAN Synapsin_N X +Prkaca PKACA P27791 rat STMN2 84510 P21818 Stmn2 rat S50 455606 KQINKRAsGQAFELI Stathmin X +Prkaca PKACA P27791 rat STMN1 29332 P13668 Stmn1 rat S16 448554 kELEKRAsGQAFELI Stathmin X 3353 +Prkaca PKACA P27791 rat PDE4B 24626 P14646 Pde4b rat S133 449097 GHSQRREsFLYRSDs X +Prkaca PKACA P27791 rat SYT7 59267 Q62747 Syt7 rat S103 4758666 RRTEPRSsVSDLVNS X +Prkaca PKACA P27791 rat NFM 24588 P12839 Nefm rat S47 457407 SWSRGSPstVSSSYK Filament_head X +Prkaca PKACA P27791 rat GLUT2 25351 P12336 Slc2a2 rat S501 451345 AAEFRKKsGsAPPRK X X +Prkaca PKACA P27791 rat PDE1A 281969 P14100 PDE1A cow S138 457690 VERMYRKsYHMVGLA X +Prkaca PKACA P27791 rat GSK3A 50686 P18265 Gsk3a rat S21 448584 SGRARtssFAEPGGG X 9337; 9316; 9331; 9327; 8452; 8566 +Prkaca PKACA P27791 rat CAMKK1 60341 P97756 Camkk1 rat S458 486077 KSMLRKRsFGNPFEP X +Prkaca PKACA P27791 rat BAD 64639 O35147 Bad rat S113 447860 ETRSRHssYPAGtEE Bcl-2_BAD X 9291; 5284; 9296; 5193; 11865; 94223 +Prkaca PKACA P27791 rat PEX5L 286937 Q925N3 Pex5l rat S237 481412 ALLsRNHsLEEEFER X +Prkaca PKACA P27791 rat AQP2 25386 P34080 Aqp2 rat S256 449854 REVRRRQsVELHsPQ X X +Prkaca PKACA P27791 rat AKAP13 11214 Q12802 AKAP13 human S2733 455336 sVsPKRNsISRTHKD X +Prkaca PKACA P27791 rat C/EBP-beta 24253 P21272 Cebpb rat S240 452156 NNIAVRKsRDKAKMR bZIP_2 X +Prkaca PKACA P27791 rat KCNN4 65206 Q9QYW1 Kcnn4 rat S332 452145 KHtRRKDsRAARRHQ CaMBD X +Prkaca PKACA P27791 rat GluR6 54257 P42260 Grik2 rat S868 478417 MVEELRMsLKCQRRL X +Prkaca PKACA P27791 rat GHF-1 25517 P10037 Pou1f1 rat S115 451519 KQELRRKsKLVEEPI X +Prkaca PKACA P27791 rat PLB 64672 P61016 Pln rat S16 448114 RSAIRRAstIEMPQQ Phospholamban X 8496 +Prkaca PKACA P27791 rat ANP-C 25339 P41740 Npr3 rat T505 15108900 FRKKYRItIERRNHQ X +Prkaca PKACA P27791 rat NFL 83613 P19527 Nefl rat S3 2872003 _____MSsFSYEPYF X +MKNK1 Mnk1 Q9BUB5 human PNPLA8 50640 Q9NP80 PNPLA8 human S511 18638838 ELYRKLGsDVFsQNV Patatin X +MKNK1 Mnk1 Q9BUB5 human SynGAP 240057 F6SEU4 Syngap1 mouse S788 19014968 MDMARLPsPtKEkPP DUF3498 X +MKNK1 Mnk1 Q9BUB5 human EIF4E 13684 P63073 Eif4e mouse T210 450199 TATKSGsttKNRFVV X X +MKNK1 Mnk1 Q9BUB5 human EIF4E 13684 P63073 Eif4e mouse S209 447776 DTATKSGsttKNRFV X X 9741 +MKNK1 Mnk1 Q9BUB5 human PSF 6421 P23246 SFPQ human S283 3182056 EGFkANLsLLRRPGE X +MKNK1 Mnk1 Q9BUB5 human PSF 6421 P23246 SFPQ human S8 25802101 MSRDRFrsrGGGGGG X +MKNK1 Mnk1 Q9BUB5 human hnRNP A1 3178 P09651 HNRNPA1 human S192 456539 EMASAsssQrGrsGs X +MKNK1 Mnk1 Q9BUB5 human hnRNP A1 3178 P09651 HNRNPA1 human S364 455936 yGGssssssyGsGrr X +MKNK1 Mnk1 Q9BUB5 human SPRY2 10253 O43597 SPRY2 human S112 465675 APLSRSIsTVssGsR X X +MKNK1 Mnk1 Q9BUB5 human EIF4E 1977 P06730 EIF4E human S209 447776 DtATksGsttKNRFV X X 9741 +MKNK1 Mnk1 Q9BUB5 human hnRNP A1 3178 P09651 HNRNPA1 human S363 456542 GyGGssssssyGsGr X +MKNK1 Mnk1 Q9BUB5 human hnRNP A1 3178 P09651 HNRNPA1 human S362 456541 GGyGGssssssyGsG X +MKNK1 Mnk1 Q9BUB5 human SPRY2 10253 O43597 SPRY2 human S121 465676 VssGsRSsTRtSTSs X X +MARK4 MARK4 Q96L34 human TNK1 8711 Q13470 TNK1 human S502 483166 RMKGIsRsLEsVLsL X +MARK4 MARK4 Q96L34 human TORC2 74343 Q3U182 Crtc2 mouse S171 454622 sALNRtSsDsALHTs TORC_M X +MARK4 MARK4 Q96L34 human TORC2 74343 Q3U182 Crtc2 mouse S275 3174300 PAMNTGGsLPDLTNL TORC_M X +MARK4 MARK4 Q96L34 human TORC2 74343 Q3U182 Crtc2 mouse S307 454633 PSLSGGNsTTNLTHT TORC_M X +AURKB AurB Q96GD4 human NuMA-1 4926 Q14980 NUMA1 human T2055 472502 MAFsILNtPkkLGNs X 14951 +AURKB AurB Q96GD4 human MgcRacGAP 29127 Q9H0H5 RACGAP1 human S387 449096 ETGLYRIsGCDRTVK RhoGAP X X +AURKB AurB Q96GD4 human HEC1 10403 O14777 NDC80 human T49 474512 kLsINkPtsERkVsL X +AURKB AurB Q96GD4 human SHCBP1 79801 Q8NEM2 SHCBP1 human S634 3206817 QIKKKRLsELGITQA X X +AURKB AurB Q96GD4 human Rb 5925 P06400 RB1 human S780 447978 strPPtLsPIPHIPr Rb_C X 9307; 3590; 8180 +AURKB AurB Q96GD4 human ZWINT 11130 O95229 ZWINT human S262 20765003 MGRDPGVsFkAVGLQ Zwint X X +AURKB AurB Q96GD4 human DNAPK 5591 P78527 PRKDC human S511 7445645 EsEDHRAsGEVRtGk DNA-PKcs_N X +AURKB AurB Q96GD4 human H2B1M 8342 Q99879 H2BC14 human Y83 11173392 EAsrLAHyNkrstIt Histone X +AURKB AurB Q96GD4 human AML2 864 Q13761 RUNX3 human T14 4733089 PSTSRRFtPPsPAFP X +AURKB AurB Q96GD4 human H2B1H 8345 Q93079 H2BC9 human Y83 11173384 EAsrLAHyNkrstIt Histone X +AURKB AurB Q96GD4 human Borealin 55143 Q53HL2 CDCA8 human T278 482837 QICssIRtHK_____ X +AURKB AurB Q96GD4 human H2B1D 3017 P58876 H2BC5 human Y83 11173360 EAsrLAHyNkrstIt Histone X +AURKB AurB Q96GD4 human INCENP 3619 Q9NQS7 INCENP human S72 4172633 RRKKRRIsyVQDENR X +AURKB AurB Q96GD4 human GFAP 2670 P14136 GFAP human S38 449621 LGPGTRLsLARMPPP Filament_head X X +AURKB AurB Q96GD4 human smMLCK 396445 P11799 MYLK chicken S140 41411900 KTPGGRLsVPPVEHR X +AURKB AurB Q96GD4 human HIST2H2BC 337873 Q6DN03 H2BC20P human S78 50780569 ERIAGEAsrLAHyNk Histone X +AURKB AurB Q96GD4 human desmin 1674 P17661 DES human T17 449613 RVssYRRtFGGAPGF Filament_head X X +AURKB AurB Q96GD4 human DEK 7913 P35659 DEK human T67 27777400 KKKVERLtMQVssLQ X +AURKB AurB Q96GD4 human K8 3856 P05787 KRT8 human T6 27777403 __MsIRVtQksykVs Keratin_2_head X +AURKB AurB Q96GD4 human CDCA5 113130 Q96FF9 CDCA5 human S126 20727702 NPEAEsssKEGELDA Sororin X X +AURKB AurB Q96GD4 human Diaphanous-2 iso4 1730 Q17R91 DIAPH2 human S820 18707505 HINNIKPsIIAVTLA FH2 X +AURKB AurB Q96GD4 human MYBBP1A 10514 Q9BQG0 MYBBP1A human S1303 3210687 ARKKARLsLVIRsPs X X +AURKB AurB Q96GD4 human CDCA5 113130 Q96FF9 CDCA5 human T111 469415 ktHsVPAtPtStPVP Sororin X X +AURKB AurB Q96GD4 human Haspin 83903 Q8TF76 HASPIN human S93 3207480 RVPKDRPsLTVtPkR X X +AURKB AurB Q96GD4 human ataxin-10 25814 Q9UBB4 ATXN10 human S12 14159379 rPPPArLsGVMVPAP X X +AURKB AurB Q96GD4 human H2B1C 8347 P62807 H2BC4 human S78 50780190 ErIAGEAsrLAHyNk Histone X +AURKB AurB Q96GD4 human DSN1 79980 Q9H410 DSN1 human S109 3595501 KETNRRksLHPIHQG MIS13 X X +AURKB AurB Q96GD4 human KIF4A 24137 O95239 KIF4A human T799 479906 PPKLRRRtFsLTEVR X X +AURKB AurB Q96GD4 human COBLL1 22837 Q53SF7 COBLL1 human S876 4721016 LQMQKRVsGHyVTSA X +AURKB AurB Q96GD4 human PPHLN1 51535 Q8NEY8 PPHLN1 human S110 476417 RDGFRRksFyssHyA X +AURKB AurB Q96GD4 human RIF1 55183 Q5UIP0 RIF1 human S2205 3201699 VNkVRRVsFADPIyQ X +AURKB AurB Q96GD4 human PLEKHG6 55200 Q3KR16 PLEKHG6 human T544 31834908 SPStRPstPsLEGSQ X X +AURKB AurB Q96GD4 human NuMA-1 4926 Q14980 NUMA1 human T1811 1245323 tRsARRRttQIINIt X +AURKB AurB Q96GD4 human NSUN2 54888 Q08J23 NSUN2 human S139 478355 SRKILRksPHLEkFH X X +AURKB AurB Q96GD4 human KIF20A 10112 O95235 KIF20A human S878 4712595 RILRsRRsPLLKsGP X X +AURKB AurB Q96GD4 human Nlp 22981 Q9Y2I6 NINL human S585 15668108 RLPKNRHsPSWsPDG X X +AURKB AurB Q96GD4 human CKAP2 26586 Q8WWK9 CKAP2 human S628 7603500 FLtPVRRsRRLQEKT CKAP2_C X X +AURKB AurB Q96GD4 human KIF2C 11004 Q99661 KIF2C human S95 451107 IQkQKRRsVNSkIPA X X +AURKB AurB Q96GD4 human desmin 1674 P17661 DES human S60 449614 VyQVsRtsGGAGGLG Filament_head X X +AURKB AurB Q96GD4 human HEC1 10403 O14777 NDC80 human S15 474511 SGGAGRLsMQELrSQ X +AURKB AurB Q96GD4 human NPM1 4869 P06748 NPM1 human S125 459897 AVEEDAEsEDEEEED X X +AURKB AurB Q96GD4 human H3 8350 P68431 H3C1 human T3 455678 _____ArtkQtArks Histone X 9714; 13576 +AURKB AurB Q96GD4 human ATM 472 Q13315 ATM human S1403 22496700 CHkTKLKsILEILSk X X +AURKB AurB Q96GD4 human AurB 9212 Q96GD4 AURKB human T16 15497293 PWPyGRQtAPsGLST X +AURKB AurB Q96GD4 human RPL21 6144 P46778 RPL21 human S104 14579432 kHSKsRDsFLkRVKE X +AURKB AurB Q96GD4 human Nlp 22981 Q9Y2I6 NINL human S448 15668107 QGYRERLsLLRSEVE X X +AURKB AurB Q96GD4 human HEC1 10403 O14777 NDC80 human S44 474539 kPtFGkLsINkPtsE X X +AURKB AurB Q96GD4 human H3 8350 P68431 H3C1 human S10 455676 tkQtArkstGGkAPr Histone X X 9701; 9711; 9606; 3465; 3642; 3377; 3475; 3458; 5764; 47398; 8481; 8552; 53348; 29237; 66065; 43185; 64522; 52725 +AURKB AurB Q96GD4 human H3 360198 P68433 H3c1 mouse S10 455676 tkQTARkstGGkAPr Histone X X 9701; 9711; 9606; 3465; 3642; 3377; 3475; 3458; 5764; 47398; 8481; 8552; 53348; 29237; 66065; 43185; 64522; 52725 +AURKB AurB Q96GD4 human RPRD1B 70470 Q9CSU0 Rprd1b mouse S145 10404515 kAAEEKKsLKRTFQQ X X +AURKB AurB Q96GD4 human ZWINT 11130 O95229 ZWINT human T251 20765002 TRPQEQstGDTMGRD Zwint X X +AURKB AurB Q96GD4 human SH2D4A 63898 Q9H788 SH2D4A human S261 7322753 REDYKRLsLGAQKGR X +AURKB AurB Q96GD4 human CASC5 57082 Q8NG31 KNL1 human S24 3829218 RPVRRRHssILkPPR X X +AURKB AurB Q96GD4 human Haspin 83903 Q8TF76 HASPIN human S4 1697837100 ____MAAsLPGPGsR X +AURKB AurB Q96GD4 human KIF2C 380006 Q91636 kif2c frog S110 2132101 KEVAAKNsLLSESGA X +AURKB AurB Q96GD4 human KIF4A 24137 O95239 KIF4A human S801 459849 KLRRRtFsLTEVRGQ X +AURKB AurB Q96GD4 human CASP2 12366 P29594 Casp2 mouse S384 1869992407 MRNTKRGsWYIEALT Peptidase_C14 X +AURKB AurB Q96GD4 human H2B1N 8341 Q99877 H2BC15 human Y83 11173388 EAsrLAHyNkrstIt Histone X +AURKB AurB Q96GD4 human H2B1M 8342 Q99879 H2BC14 human S78 50780223 ErIAGEAsrLAHyNk Histone X +AURKB AurB Q96GD4 human SEPT1 1731 Q8WYJ6 SEPTIN1 human S320 457108 RSKLSRQsAtEIPLP X +AURKB AurB Q96GD4 human KIF2C 11004 Q99661 KIF2C human S115 2132104 RsRstRMstVSELRI X +AURKB AurB Q96GD4 human RPS10 6204 P46783 RPS10 human T118 25752435 GERPARLtrGEADRD X +AURKB AurB Q96GD4 human H3F3A 3020 P84243 H3-3A human S10 18545301 tkQTARkstGGkAPR Histone X X 9706; 3458 +AURKB AurB Q96GD4 human HMGN2 3151 P05204 HMGN2 human S29 2574920 QRRsARLsAkPAPPk HMG14_17 X X +AURKB AurB Q96GD4 human DDX52 11056 Q9Y2R4 DDX52 human S22 10155029 kFDTRRFsADAArFQ X +AURKB AurB Q96GD4 human IkB-alpha 4792 P25963 NFKBIA human S262 1873119302 QLTWGRPsTRIQQQL X +AURKB AurB Q96GD4 human HIST1H2BJ 8970 P06899 H2BC11 human Y83 21691330 EAsrLAHyNkrstIT Histone X +AURKB AurB Q96GD4 human HEC1 10403 O14777 NDC80 human S5 474510 ___MKRSsVsSGGAG X +AURKB AurB Q96GD4 human HIST2H2BD 337874 Q6DRA6 H2BC19P human Y83 34433758 EAsrLAHyNkRSTIT Histone X +AURKB AurB Q96GD4 human ARHGAP21 57584 Q5T5U3 ARHGAP21 human S131 27777421 IIKVNGEsVIGKTYS PDZ_6 X +AURKB AurB Q96GD4 human AML2 864 Q13761 RUNX3 human T173 55571501 YHRAIkVtVDGPREP Runt X +AURKB AurB Q96GD4 human HP1 alpha 23468 P45973 CBX5 human S92 455944 SESNKRksNFsNsAD X X +AURKB AurB Q96GD4 human H2B1H 8345 Q93079 H2BC9 human S78 50780205 ErIAGEAsrLAHyNk Histone X +AURKB AurB Q96GD4 human H2B2F 440689 Q5QNW6 H2BC18 human S78 50780244 ErIAGEAsrLAHyNk Histone X +AURKB AurB Q96GD4 human HSP90B 3326 P08238 HSP90AB1 human S452 2565363 stNRRRLsELLRyHt HSP90 X +AURKB AurB Q96GD4 human HEC1 10403 O14777 NDC80 human S55 459763 PtsERkVsLFGkRts Ndc80_HEC X X +AURKB AurB Q96GD4 human H3F3A 3020 P84243 H3-3A human S28 18545302 ATkAARksAPsTGGV Histone X X +AURKB AurB Q96GD4 human CDT1 81620 Q9H211 CDT1 human T102 31889833 GQKIKKStPAAGQPP X +AURKB AurB Q96GD4 human p53 7157 P04637 TP53 human S183 18675301 CPHHERCsDsDGLAP P53 X X +AURKB AurB Q96GD4 human NAGK 55577 Q9UJ70 NAGK human S76 3245045 RsLGLsLsGGDQEDA BcrAD_BadFG X +AURKB AurB Q96GD4 human PLEKHG6 55200 Q3KR16 PLEKHG6 human T620 31834904 LRRDPRLtFSTLELR X +AURKB AurB Q96GD4 human LMO7 4008 Q8WWI1 LMO7 human S300 4687515 DMsyRRIsAVEPkTA DUF4757 X +AURKB AurB Q96GD4 human HIST1H2BJ 8970 P06899 H2BC11 human S78 50780565 ErIAGEAsrLAHyNk Histone X +AURKB AurB Q96GD4 human H3 8350 P68431 H3C1 human S28 455677 ATkAArksAPATGGV Histone X X 9713 +AURKB AurB Q96GD4 human LMO7 4008 Q8WWI1 LMO7 human S751 4687531 kWKDRRksYtsDLQK DUF4757 X +AURKB AurB Q96GD4 human NSBP1 79366 P82970 HMGN5 human S20 456122 RQEPKRRsARLsAML HMG14_17 X +AURKB AurB Q96GD4 human KIBRA 23286 Q8IX03 WWC1 human S539 20751200 tsLsPRSsLSsPSPP X X +AURKB AurB Q96GD4 human PLEKHG6 55200 Q3KR16 PLEKHG6 human S645 27458320 PQAPQRRsAPELPEG X +AURKB AurB Q96GD4 human GFAP 2670 P14136 GFAP human S13 449619 ItsAArrsyVSsGEM Filament_head X X +AURKB AurB Q96GD4 human H2B1N 8341 Q99877 H2BC15 human S78 50780230 ErIAGEAsrLAHyNk Histone X +AURKB AurB Q96GD4 human Haspin 83903 Q8TF76 HASPIN human S143 3207474 PPFPsRDsGRLsPDL X X +AURKB AurB Q96GD4 human RPL8 6132 P62917 RPL8 human S130 15423003 RGKLARAsGNyATVI Ribosomal_L2_C X +AURKB AurB Q96GD4 human KIF2C 11004 Q99661 KIF2C human S109 2132103 APkEsLRsRstRMst X +AURKB AurB Q96GD4 human HIST2H2BC 337873 Q6DN03 H2BC20P human Y83 34433756 EAsrLAHyNkRSTIT Histone X +AURKB AurB Q96GD4 human MIS18A 54069 Q9NYP9 MIS18A human S36 18012204 sLLGkrLsEDssRHQ X X +AURKB AurB Q96GD4 human CASC5 57082 Q8NG31 KNL1 human S60 459643 KKNSRRVsFADTIKV X X +AURKB AurB Q96GD4 human Survivin 332 O15392 BIRC5 human T34 447705 FLEGCACtPERMAEA BIR X 8888 +AURKB AurB Q96GD4 human SSU72 29101 Q9NP77 SSU72 human S3 10940613 _____MPssPLRVAV X +AURKB AurB Q96GD4 human p53 7157 P04637 TP53 human S269 17677100 GNLLGRNsFEVRVCA P53 X X +AURKB AurB Q96GD4 human KIF2C 11004 Q99661 KIF2C human S111 25159900 kEsLRsRstRMstVS X +AURKB AurB Q96GD4 human Diaphanous-2 iso4 1730 Q17R91 DIAPH2 human T882 18707507 KSADQKTtLLHFIAD FH2 X +AURKB AurB Q96GD4 human CDT1 81620 Q9H211 CDT1 human T358 1239966007 PPATEkLtTAQEVLA X +AURKB AurB Q96GD4 human SSU72 29101 Q9NP77 SSU72 human S19 29614601 CSSNQNRsMEAHNIL Ssu72 X X +AURKB AurB Q96GD4 human Borealin 55143 Q53HL2 CDCA8 human S154 482835 PSKKRtQsIQGKGKG X +AURKB AurB Q96GD4 human H2B 3018 P33778 H2BC3 human S78 50780176 ErIAGEAsrLAHyNk Histone X +AURKB AurB Q96GD4 human H2B1C 8347 P62807 H2BC4 human Y83 11173364 EAsrLAHyNkrstIt Histone X +AURKB AurB Q96GD4 human PLEKHG6 55200 Q3KR16 PLEKHG6 human T540 31834906 QDRESPStRPstPsL X +AURKB AurB Q96GD4 human SAS10 57050 Q9NQZ2 UTP3 human S462 12668129 RKEEQRYsGELsGIR Sas10 X +AURKB AurB Q96GD4 human CDCA5 113130 Q96FF9 CDCA5 human S139 20727378 DARDLEMsKKVRRsy Sororin X X +AURKB AurB Q96GD4 human IkB-alpha 4792 P25963 NFKBIA human S32 448203 LLDDRHDsGLDsMkD X 5210; 2859; 9246; 5209 +AURKB AurB Q96GD4 human KIF2C 380006 Q91636 kif2c frog S196 2132102 NNQGRRKsNIVKEME X X +AURKB AurB Q96GD4 human CDT1 81620 Q9H211 CDT1 human S143 1239966006 RVRALkAsAQDAGES X +AURKB AurB Q96GD4 human ZWINT 11130 O95229 ZWINT human S250 20765004 PTRPQEQstGDTMGR Zwint X X +AURKB AurB Q96GD4 human SSH3 54961 Q8TE77 SSH3 human S37 467353 SRLQRRQsFAVLRGA X 13873 +AURKB AurB Q96GD4 human H3 291159 Q6LED0 Hist1h2ail1 rat S10 455676 tkQTARkstGGkAPR Histone X 9701; 9711; 9606; 3465; 3642; 3377; 3475; 3458; 5764; 47398; 8481; 8552; 53348; 29237; 66065; 43185; 64522; 52725 +AURKB AurB Q96GD4 human AHNAK 79026 Q09666 AHNAK human T158 2565491 ItVtRRVtAytVDVT X +AURKB AurB Q96GD4 human CSIG 26156 O76021 RSL1D1 human T312 27777405 KRQQARktAsVLskD X +AURKB AurB Q96GD4 human RBMX 27316 P38159 RBMX human S326 3190081 GyGGsRDsysssRsD X +AURKB AurB Q96GD4 human INCENP 3619 Q9NQS7 INCENP human T494 27777401 kVVRPLRtFLHtVQR X +AURKB AurB Q96GD4 human CDCA5 113130 Q96FF9 CDCA5 human S33 472118 LRRsQRKsGsELPsI X X +AURKB AurB Q96GD4 human RBM3 5935 P98179 RBM3 human S147 3193835 QGGyDrysGGNyRDN X +AURKB AurB Q96GD4 human INCENP 3619 Q9NQS7 INCENP human S894 450468 RYHKRtssAVWNsPP X X +AURKB AurB Q96GD4 human 53BP1 7158 Q12888 TP53BP1 human S1342 3194873 GPLrGktsGtEPADF X X +AURKB AurB Q96GD4 human RPRD1B 58490 Q9NQG5 RPRD1B human S145 10404515 KATEEKKsLKRTFQQ X X +AURKB AurB Q96GD4 human ZFYVE19 84936 Q96K21 ZFYVE19 human S22 34488101 yAGCRRAsGFPALGR X +AURKB AurB Q96GD4 human DDX3 1654 O00571 DDX3X human S594 3174419 rSKssrFsGGFGArD X +AURKB AurB Q96GD4 human INCENP 3619 Q9NQS7 INCENP human S899 459782 tssAVWNsPPLQGAR X +AURKB AurB Q96GD4 human KIF2C 11004 Q99661 KIF2C human S192 2132102 VNsVRRKsCLVkEVE X +AURKB AurB Q96GD4 human H2BFH 8348 P23527 H2BC17 human Y83 11173345 EAsrLAHyNkrstIt Histone X +AURKB AurB Q96GD4 human PLEKHG6 55200 Q3KR16 PLEKHG6 human S546 31834907 StRPstPsLEGSQSS X +AURKB AurB Q96GD4 human hnRNP U 3192 Q00839 HNRNPU human S14 18010531 NVkKLkVsELkEELk SAP X +AURKB AurB Q96GD4 human GFAP 2670 P14136 GFAP human T7 449617 _MERRRItsAArrsy Filament_head X X +AURKB AurB Q96GD4 human AurB 9212 Q96GD4 AURKB human S7 459674 _MAQkENsyPWPyGR X +AURKB AurB Q96GD4 human Diaphanous-2 iso4 1730 Q17R91 DIAPH2 human T66 11147321 ITSFRKStVKKEKPL X +AURKB AurB Q96GD4 human RPA1 6117 P27694 RPA1 human S384 3189442 AIkGARVsDFGGRSL REPA_OB_2 X X +AURKB AurB Q96GD4 human p53 7157 P04637 TP53 human T284 18675300 CPGRDRRtEEENLrk P53 X X +AURKB AurB Q96GD4 human AurB 9212 Q96GD4 AURKB human T232 450325 APsLRRktMCGtLDy Pkinase X X 2914; 13464; 8525 +AURKB AurB Q96GD4 human HMGN2 3151 P05204 HMGN2 human S25 3146800 kDEPQRRsARLsAkP HMG14_17 X X +AURKB AurB Q96GD4 human smMLCK 396445 P11799 MYLK chicken S149 17555039 PPVEHRPsIWGESPP X +AURKB AurB Q96GD4 human MRLC2 103910 O14950 MYL12B human S20 448595 KRPQRAtsNVFAMFD X +AURKB AurB Q96GD4 human YY1 7528 P25490 YY1 human S184 476106 GKKsGKksyLsGGAG X X +AURKB AurB Q96GD4 human PAR3-alpha 56288 Q8TEW0 PARD3 human S962 11279402 SSRsGREsVSTAsDQ X X +AURKB AurB Q96GD4 human INCENP 3619 Q9NQS7 INCENP human S518 27777402 APRsVMKsFIKRNtP X +AURKB AurB Q96GD4 human PLK1 5347 P53350 PLK1 human T210 448139 YDGERKktLCGtPNy Pkinase X 4354; 5472; 9062 +AURKB AurB Q96GD4 human RDBP 7936 P18615 NELFE human S131 3181196 SRRPQRksLyEsFVS X +AURKB AurB Q96GD4 human CDCA2 157313 Q69YH5 CDCA2 human S977 10424830 EPGKRRKsFCIsTLA X X +AURKB AurB Q96GD4 human KIF23 iso2 9493 Q02241-2 KIF23 human S708 2902205 IRLRHRRsRsAGDRW MKLP1_Arf_bdg X +AURKB AurB Q96GD4 human CCDC86 79080 Q9H6F5 CCDC86 human S255 3965729 DRsKKRFsQMLQDkP Cgr1 X +AURKB AurB Q96GD4 human Borealin 55143 Q53HL2 CDCA8 human S165 475063 KGKGKRssRANtVtP Borealin X +AURKB AurB Q96GD4 human H2B2E 8349 Q16778 H2BC21 human Y83 11173368 EAsrLAHyNkrstIt Histone X +AURKB AurB Q96GD4 human Vimentin 7431 P08670 VIM human S73 449025 sAVrLrssVPGVRLL Filament_head X X +AURKB AurB Q96GD4 human hnRNP U 3192 Q00839 HNRNPU human S26 476219 ELkKRRLsDkGLkAE SAP X +AURKB AurB Q96GD4 human MgcRacGAP 29127 Q9H0H5 RACGAP1 human T249 478691 WTRSRRktGtLQPWN X +AURKB AurB Q96GD4 human NuMA-1 4926 Q14980 NUMA1 human S2047 4748253 kQADRRQsMAFsILN X +AURKB AurB Q96GD4 human H2B2E 8349 Q16778 H2BC21 human S78 50780236 ErIAGEAsrLAHyNk Histone X +AURKB AurB Q96GD4 human MYH10 4628 P35580 MYH10 human T1847 1874404500 ANKLVRRtEKKLKEI Myosin_tail_1 X X +AURKB AurB Q96GD4 human Nlp 22981 Q9Y2I6 NINL human S185 15668109 WDSEDFGsPQKSCsP X X +AURKB AurB Q96GD4 human CDCA5 113130 Q96FF9 CDCA5 human S83 3208977 PRRsPRIsFFLEKEN X X +AURKB AurB Q96GD4 human CDCA2 157313 Q69YH5 CDCA2 human S893 28698800 sETKVRRsTRLQKDL X X +AURKB AurB Q96GD4 human H3 360198 P68433 H3c1 mouse S28 455677 ATkAArksAPATGGV Histone X 9713 +AURKB AurB Q96GD4 human INCENP 3619 Q9NQS7 INCENP human T892 450466 KPRYHKRtssAVWNs X +AURKB AurB Q96GD4 human Oct4 18999 P20263 Pou5f1 mouse T343 291887109 AFPSVPVtALGsPMH X +AURKB AurB Q96GD4 human INCENP 3619 Q9NQS7 INCENP human T59 458332 EPELMPKtPSQKNRR X +AURKB AurB Q96GD4 human CHMP4C 92421 Q96CF2 CHMP4C human S215 1221009 RRsRAAssQRAEEED X X +AURKB AurB Q96GD4 human H2B1D 3017 P58876 H2BC5 human S78 50780196 ErIAGEAsrLAHyNk Histone X +AURKB AurB Q96GD4 human H2BFH 8348 P23527 H2BC17 human S78 50780248 ErIAGEAsrLAHyNk Histone X +AURKB AurB Q96GD4 human H2B1K 85236 O60814 H2BC12 human Y83 11173341 EAsrLAHyNkrstIt Histone X +AURKB AurB Q96GD4 human IkB-alpha 4792 P25963 NFKBIA human S63 1873119300 PQEVPRGsEPWkQQL X +AURKB AurB Q96GD4 human CDCA5 113130 Q96FF9 CDCA5 human T159 483401 LGsAStstPGRRsCF Sororin X X +AURKB AurB Q96GD4 human PLEKHG6 55200 Q3KR16 PLEKHG6 human S697 31834903 LRGQLPSsPTHADSA X +AURKB AurB Q96GD4 human CKAP2 26586 Q8WWK9 CKAP2 human T39 27446366 EHLLRRktLFAYKQE X +AURKB AurB Q96GD4 human HIST2H2BD 337874 Q6DRA6 H2BC19P human S78 50780571 ERIAGEAsrLAHyNk Histone X +AURKB AurB Q96GD4 human NSBP1 79366 P82970 HMGN5 human S24 456123 KRRsARLsAMLVPVt HMG14_17 X +AURKB AurB Q96GD4 human RBM14 10432 Q96PK6 RBM14 human S618 468597 LsDyrRLsEsQLsFR X +AURKB AurB Q96GD4 human MISP 126353 Q8IVT2 MISP human S348 27445089 RRERGRPsLyVQRDI AKAP2_C X +AURKB AurB Q96GD4 human SEPT1 1731 Q8WYJ6 SEPTIN1 human S312 457107 PGARDRAsRSKLSRQ X +AURKB AurB Q96GD4 human EB3 22924 Q9UPY8 MAPRE3 human S176 4740060 MQTSGRLsNVAPPCI X X +AURKB AurB Q96GD4 human CDCA5 113130 Q96FF9 CDCA5 human T151 28750703 RsysRLEtLGsASts Sororin X X +AURKB AurB Q96GD4 human Diaphanous-2 iso4 1730 Q17R91 DIAPH2 human S196 18707506 CLESLRVsLTSNPVS Drf_GBD X X +AURKB AurB Q96GD4 human CDCA5 113130 Q96FF9 CDCA5 human S164 9316471 tstPGRRsCFGFEGL Sororin X X +AURKB AurB Q96GD4 human H2B1K 85236 O60814 H2BC12 human S78 50780211 ErIAGEAsrLAHyNk Histone X +AURKB AurB Q96GD4 human INCENP 16319 Q9WU62 Incenp mouse S862 450468 RYHKRtssAVWNsPP X +AURKB AurB Q96GD4 human ARHGAP23 57636 Q9P227 ARHGAP23 human S127 27777422 LVkVNGEsVIGKTYS PDZ_6 X +AURKB AurB Q96GD4 human MCL1 4170 Q07820 MCL1 human T301 1868532700 ITDVLVRtkRDWLVk Bcl-2 X +AURKB AurB Q96GD4 human NuMA-1 4926 Q14980 NUMA1 human S1969 3196643 QEtLRRAsMQPIQIA X +AURKB AurB Q96GD4 human PTRF 284119 Q6NZI2 CAVIN1 human S300 465873 SRDkLRksFtPDHVV PTRF_SDPR X +AURKB AurB Q96GD4 human SPT16 11198 Q9Y5B9 SUPT16H human T494 7997652 EEAkRRLtEQkGEQQ X +AURKB AurB Q96GD4 human GBF1 8729 Q92538 GBF1 human S174 2565467 ICFEMRLsELLRKSA DCB X +AURKB AurB Q96GD4 human H2B 3018 P33778 H2BC3 human Y83 11173348 EAsrLAHyNkrstIt Histone X +AURKB AurB Q96GD4 human CDCA5 113130 Q96FF9 CDCA5 human T115 469416 VPAtPtStPVPNPEA Sororin X X +AURKB AurB Q96GD4 human CDCA2 157313 Q69YH5 CDCA2 human S981 26418520 RRKsFCIsTLANTKA X X +AURKB AurB Q96GD4 human Survivin 332 O15392 BIRC5 human T117 450947 kNkIAkEtNNkkkEF X X +AURKB AurB Q96GD4 human desmin 1674 P17661 DES human S12 449612 ysSSQRVssYRRtFG Filament_head X X +AURKB AurB Q96GD4 human CDT1 81620 Q9H211 CDT1 human T7 1239966005 _MEQRRVtDFFARRR X +AURKB AurB Q96GD4 human p53 7157 P04637 TP53 human S215 454242 DrNtFrHsVVVPyEP P53 X X +AURKB AurB Q96GD4 human INCENP 3619 Q9NQS7 INCENP human S893 450467 PRYHKRtssAVWNsP X X +AURKB AurB Q96GD4 human HEC1 10403 O14777 NDC80 human S69 474513 sGHGsRNsQLGIFss Ndc80_HEC X +AURKB AurB Q96GD4 human PLEKHG6 55200 Q3KR16 PLEKHG6 human S543 31834905 ESPStRPstPsLEGS X +AURKB AurB Q96GD4 human PRRC2C 23215 Q9Y520 PRRC2C human S1013 27777419 NDRPVRRsGPIKKPV X +AURKB AurB Q96GD4 human NPM1 18148 Q61937 Npm1 mouse S125 459897 AVEEDAEsEDEDEED X +AURKB AurB Q96GD4 human DSN1 79980 Q9H410 DSN1 human S100 480153 RQsWRRAsMKETNRR MIS13 X X +AURKB AurB Q96GD4 human NUDC 10726 Q9Y266 NUDC human T40 11164887 FSFLRRktDFFIGGE Nudc_N X +AURKB AurB Q96GD4 human CHMP4C 92421 Q96CF2 CHMP4C human S210 25123900 MSSTARRsRAAssQR X X +AURKB AurB Q96GD4 human NUSAP1 51203 Q9BXS6 NUSAP1 human S240 469451 VPPRGRLsVAstPIs NUSAP X +AURKB AurB Q96GD4 human RBM14 10432 Q96PK6 RBM14 human S649 3209652 HsDyArysGsyNDyL X +AURKB AurB Q96GD4 human HSP90B 3326 P08238 HSP90AB1 human S255 449266 PKIEDVGsDEEDDsG HSP90 X +AURKB AurB Q96GD4 human Haspin 83903 Q8TF76 HASPIN human S108 7990677 WKLRARPsLtVtPRR X X +AURKB AurB Q96GD4 human Borealin 55143 Q53HL2 CDCA8 human S275 482836 RLAQICssIRtHK__ Borealin X +AURKB AurB Q96GD4 human KI-67 4288 P46013 MKI67 human S374 459806 ytTGRREsVNLGkSE X +AURKB AurB Q96GD4 human Borealin 55143 Q53HL2 CDCA8 human S219 460351 YNIsGNGsPLADskE Borealin X +AURKB AurB Q96GD4 human p53 7157 P04637 TP53 human T211 25535400 EYLDDrNtFrHsVVV P53 X X +AURKB AurB Q96GD4 human CENPA 1058 P49450 CENPA human S7 448601 _MGPRRRsRKPEAPR Histone X 2187 +AURKB AurB Q96GD4 human RASSF1 iso2 11186 Q9NS23-2 RASSF1 human S203 484000 TsVRRRtsFYLPKDA RA X X +AURKB AurB Q96GD4 human DDA1 79016 Q9BW61 DDA1 human S33 1211350 kAsNRRPsVyLPTRE DDA1 X +AURKB AurB Q96GD4 human KIF23 9493 Q02241 KIF23 human S911 459840 NGsRKRRsstVAPAQ X +AURKB AurB Q96GD4 human SSU72 29101 Q9NP77 SSU72 human S4 10940616 ____MPssPLRVAVV X +AURKB AurB Q96GD4 human KIF2C 380006 Q91636 kif2c frog T95 451107 SQNHKRKtISKIPAP X X +AURKB AurB Q96GD4 human MPHOSPH10 10199 O00566 MPHOSPH10 human T332 14576278 KESLKRVtFALPDDA Mpp10 X +AURKB AurB Q96GD4 human SEPT1 1731 Q8WYJ6 SEPTIN1 human S253 457106 PVRGRRysWGtVEVE Septin X +AURKB AurB Q96GD4 human KI-67 4288 P46013 MKI67 human S538 3148110 EAPTKRksLVMHtPP PP1_bind X +AURKB AurB Q96GD4 human PKM 5315 P14618 PKM human T45 476071 PPItARNtGIICtIG PK X X +AURKB AurB Q96GD4 human CDCA5 113130 Q96FF9 CDCA5 human S79 470691 AVQsPRRsPRIsFFL X X +AURKB AurB Q96GD4 human CHMP4C 92421 Q96CF2 CHMP4C human S214 1247825 ARRsRAAssQRAEEE X X +AURKB AurB Q96GD4 human USP13 8975 Q92995 USP13 human S114 3849419 ALPkRRNsKIFLDLD X X +AURKB AurB Q96GD4 human DDX3Y 8653 O15523 DDX3Y human S592 4271209 RSKSNrFsGGFGArD X +AURKB AurB Q96GD4 human HDAC5 10014 Q9UQL6 HDAC5 human S278 4788482 QKVAERRssPLLRRK X X +AURKB AurB Q96GD4 human H2B2F 440689 Q5QNW6 H2BC18 human Y83 11173373 EAsrLAHyNkrstIt Histone X +AURKB AurB Q96GD4 human Plectin-1 5339 Q15149 PLEC human T2886 480098 PVRNRRLtVNEAVKE Plectin X +AURKB AurB Q96GD4 human INCENP 16319 Q9WU62 Incenp mouse S861 450467 TRYHKRtssAVWNsP X +AURKB AurB Q96GD4 human RBMXL1 494115 Q96E39 RBMXL1 human S326 11537510 GyGGsRDsysSSRsD X +RPS6KA2 RSK3 Q15349 human BUD13 84811 Q9BRD0 BUD13 human T159 470734 PRRARHDtPDPsPLR X X +RPS6KA2 RSK3 Q15349 human RSK3 6196 Q15349 RPS6KA2 human S218 1883400 DHDKRAysFCGtIEY Pkinase X +RPS6KA2 RSK3 Q15349 human BUD13 84811 Q9BRD0 BUD13 human S235 1221273 PRRARHGssDIssPR X X +RPS6KA2 RSK3 Q15349 human RSK3 6196 Q15349 RPS6KA2 human T570 478057 AGNGLLMtPCytANF Pkinase X +RPS6KA2 RSK3 Q15349 human CREB 1385 P16220 CREB1 human S119 448228 EILsRRPsyRkILND pKID X 9187; 9196; 9198; 4095; 14228; 14001; 39561; 80120; 44864; 54960; 95995 +RPS6KA2 RSK3 Q15349 human ataxin-1 6310 P54253 ATXN1 human S775 449110 AtRKRRWsAPESRKL X X +Fam20c FAM20C Q5MJS3 mouse FGF23 8074 Q9GZV9 FGF23 human S180 33365504 IPRRHtRsAEDDSER X +Fam20c FAM20C Q5MJS3 mouse HRC 3270 P23327 HRC human S96 34499322 EKEDEDVsKEyGHLL X +Fam20c FAM20C Q5MJS3 mouse FGF23 8074 Q9GZV9 FGF23 human S207 36400703 TPAPASCsQELPsAE X +Fam20c FAM20C Q5MJS3 mouse FGF23 64654 Q9EPC2 Fgf23 mouse S212 36400702 SCSRELPsAEEGGPA X +Fam20c FAM20C Q5MJS3 mouse FGF23 8074 Q9GZV9 FGF23 human S212 36400702 SCsQELPsAEDNSPM X +Mylk2 skMLCK Q8VCR8 mouse MYL7 17898 Q9QVP4 Myl7 mouse S23 465733 KQAQRGssNVFsMFE X +Mylk2 skMLCK Q8VCR8 mouse MYL7 17898 Q9QVP4 Myl7 mouse S22 465732 TKQAQRGssNVFsMF X +BLK BLK P51451 human BLK 12143 P16277 Blk mouse Y383 447715 ARIIDSEyTAQEGAK PK_Tyr_Ser-Thr X 70926; 78740; 94361; 17320 +BLK BLK P51451 human FAM83A 84985 Q86UY5 FAM83A human Y138 463316 EKssAtVyFQtVKHN FAM83 X X +BLK BLK P51451 human FCGR2A 2212 P12318 FCGR2A human Y304 449552 tDDDKNIyLTLPPND X +BLK BLK P51451 human FCGR2B 2213 P31994 FCGR2B human Y292 448507 GAENTITysLLMHPD X +BLK BLK P51451 human FCGR2A 2212 P12318 FCGR2A human Y288 449553 yEtADGGyMtLNPRA X +BLK BLK P51451 human SOCS1 8651 O15524 SOCS1 human Y80 1868450203 LLDACGFyWGPLSVH SH2 X +BLK BLK P51451 human cGAS 115004 Q8N884 CGAS human Y215 1271626200 LLNTGSYyEHVKIsA Mab-21 X +BLK BLK P51451 human FCGR2C 9103 P31995 FCGR2C human Y310 449501 tDDDKNIyLTLPPND X +BLK BLK P51451 human DBNL 13169 Q62418 Dbnl mouse Y340 450090 QTEEEPTyEVPPEQD X +BLK BLK P51451 human DBNL 13169 Q62418 Dbnl mouse Y350 450091 PPEQDTLyEEPPLVQ X +Csnk1e CK1E Q9JJ76 rat DARPP-32 360616 Q6J4I0 Ppp1r1b rat S137 448046 EEDEEEDsQAEVLKG DARPP-32 X +Csnk1e CK1E Q9JJ76 rat DARPP-32 360616 Q6J4I0 Ppp1r1b rat T34 448047 MIRRRRPtPALLFRV DARPP-32 X 12438 +BRD4 BRD4 O60885 human POLR2A 20020 P08775 Polr2a mouse S1616 450204 TPQSPSYsPtsPSYS RNA_pol_Rpb1_R X 4735; 13499; 13546; 31262 +BRD4 BRD4 O60885 human POLR2A 5430 P24928 POLR2A human S1616 450204 TPQSPSysPtsPsYS RNA_pol_Rpb1_R X X 4735; 13499; 13546; 31262 +Rock2 ROCK2 P70336 mouse MRLC1 10398 P24844 MYL9 human T19 1863501 KKRPQRAtsNVFAMF X 3674; 95777 +Rock2 ROCK2 P70336 mouse Ezrin 22350 P26040 Ezr mouse T567 448104 QGRDKYKtLRQIRQG ERM_C X X 3141; 3726; 32600 +Rock2 ROCK2 P70336 mouse calponin 3 71994 Q9DAW9 Cnn3 mouse S293 4776192 QGtGTNGsEIsDsDy X +Rock2 ROCK2 P70336 mouse IRS1 16367 P35569 Irs1 mouse S635 447507 yMPMsPKsVsAPQQI X X 2388 +Rock2 ROCK2 P70336 mouse MRLC2 67938 Q3THE2 Myl12b mouse S20 448595 KRPQRAtsNVFAMFD X +Rock2 ROCK2 P70336 mouse Moesin 17698 P26041 Msn mouse T558 447706 LGRDKYKtLRQIRQG ERM_C X X 3141; 3726; 32600 +Rock2 ROCK2 P70336 mouse Radixin 19684 P26043 Rdx mouse T564 448374 AGRDKYKtLRQIRQG ERM_C X X 3141; 3726; 32600 +Rock2 ROCK2 P70336 mouse ADD1 11518 Q9QYC0 Add1 mouse S724 449829 KKKFRtPsFLKKSKK X +Rock2 ROCK2 P70336 mouse IRF4 16364 Q64287 Irf4 mouse S447 12265165 HRSLRHssIQE____ X +Rock2 ROCK2 P70336 mouse calponin 3 71994 Q9DAW9 Cnn3 mouse S296 4776198 GTNGsEIsDsDyQAE X +Rock2 ROCK2 P70336 mouse IRS1 16367 P35569 Irs1 mouse S632 447506 NGDyMPMsPKsVsAP X X 2388 +Rock2 ROCK2 P70336 mouse IRF4 16364 Q64287 Irf4 mouse S446 26335000 YHRSLRHssIQE___ X +Rock2 ROCK2 P70336 mouse Cofilin-1 1072 P23528 CFL1 human S3 448444 _____MAsGVAVsDG X 3313; 3311 +Mylk2 skMLCK P20689 rat skMLCK 117558 P20689 Mylk2 rat S168 2864200 PAFLHsPsCPAIISC X +MYLK smMLCK P11799 chicken MRLC1 296313 Q64122 Myl9 rat S20 1863500 KRPQSAtsNVFAMFD X 3674; 3671; 3675; 95777 +MYLK smMLCK P11799 chicken smMLCK 396445 P11799 MYLK chicken S1765 468781 GRKAsGssPTsPINA X +MYLK smMLCK P11799 chicken TNNI3 21954 P48787 Tnni3 mouse T144 451483 RGKFKRPtLRRVRIs Troponin X +MYLK smMLCK P11799 chicken MRLC3 10627 P19105 MYL12A human S19 7382102 KRPQRAtsNVFAMFD X +MYLK smMLCK P11799 chicken MRLC1 296313 Q64122 Myl9 rat T19 1863501 KKRPQSAtsNVFAMF X 3674; 95777 +MYLK smMLCK P11799 chicken smMLCK 396445 P11799 MYLK chicken T1797 2874403 PHVKPYFtKtILDME I-set X +MYLK smMLCK P11799 chicken smMLCK 396445 P11799 MYLK chicken S1749 466361 RAIGRLSsMAMISGM X +MYLK smMLCK P11799 chicken TNNI3 21954 P48787 Tnni3 mouse S45 450691 KKSKIsAsRKLQLkT X +MYLK smMLCK P11799 chicken smMLCK 396445 P11799 MYLK chicken S1757 2874409 MAMISGMsGRKAsGs X +MYLK smMLCK P11799 chicken smMLCK 396445 P11799 MYLK chicken T1799 2874402 VKPYFtKtILDMEVV I-set X +MYLK smMLCK P11799 chicken MRLC1 10398 P24844 MYL9 human S20 1863500 KRPQRAtsNVFAMFD X 3674; 3671; 3675; 95777 +MYLK smMLCK P11799 chicken MRLC1 98932 Q9CQ19 Myl9 mouse S20 1863500 KRPQRAtsNVFAMFD X 3674; 3671; 3675; 95777 +MYLK smMLCK P11799 chicken MRLC1 98932 Q9CQ19 Myl9 mouse T19 1863501 KKRPQRAtsNVFAMF X 3674; 95777 +MYLK smMLCK P11799 chicken smMLCK 396445 P11799 MYLK chicken T1737 2874410 ARRKWQKtGHAVRAI X +MYLK smMLCK P11799 chicken smMLCK 396445 P11799 MYLK chicken S1764 2874401 sGRKAsGssPTsPIN X +MYLK smMLCK P11799 chicken TNNI3 21954 P48787 Tnni3 mouse S43 450690 AkKKSKIsAsRKLQL X +MYLK smMLCK P11799 chicken MRLC3 10627 P19105 MYL12A human T18 7382101 KKRPQRAtsNVFAMF X +Bckdk BCKDK Q00972 rat BCKDH E1-alpha 25244 P11960 Bckdha rat S333 449636 TYRIGHHstsDDSSA E1_dh X X 40368 +Bckdk BCKDK Q00972 rat BCKDH E1-alpha 593 P12694 BCKDHA human S347 451657 DDssAyRsVDEVNyW E1_dh X +Bckdk BCKDK Q00972 rat BCKDK 29603 Q00972 Bckdk rat S52 2874404 ERSKTVTsFYNQSAI X +Bckdk BCKDK Q00972 rat BCKDH E1-alpha 25244 P11960 Bckdha rat S343 451657 DDSSAyRsVDEVNYW E1_dh X +Bckdk BCKDK Q00972 rat BCKDHB 594 P21953 BCKDHB human S318 3336900 DVDTICKsVIKTGRL Transketolase_C X +Bckdk BCKDK Q00972 rat BCKDH E1-alpha 593 P12694 BCKDHA human S337 449636 TYRIGHHstsDDssA E1_dh X 40368 +NEK2 NEK2 P51955 human NEK2 4751 P51955 NEK2 human S241 12574600 RRIPYRYsDELNEII Pkinase X +NEK2 NEK2 P51955 human Tara iso5 11078 Q9H2D6-5 TRIOBP human T221 33365503 RRKWFEAtDSRTPEV X +NEK2 NEK2 P51955 human CEP250 11190 Q9BV73 CEP250 human S2417 20831304 ETRRLDEsLtQsLTs X +NEK2 NEK2 P51955 human LIP8 116840 Q8N137 CNTROB human S41 27565613 VtsQLYAsLRLsRQA X +NEK2 NEK2 P51955 human NPM1 4869 P06748 NPM1 human S88 4169620 MsVQPtVsLGGFEIt Nucleoplasmin X +NEK2 NEK2 P51955 human SGO1 151648 Q5FBB7 SGO1 human S14 486241 LKKSFQDsLEDIkKR X X +NEK2 NEK2 P51955 human EEF2 1938 P13639 EEF2 human S595 27620701 NVLCLsksPNkHNRL X +NEK2 NEK2 P51955 human NEK2 4751 P51955 NEK2 human S397 1983725 skENIMRsENsEsQL X +NEK2 NEK2 P51955 human NEK2 4751 P51955 NEK2 human S428 12574605 QLRAQALsDIEkNYQ X +NEK2 NEK2 P51955 human DVL3 1857 Q92997 DVL3 human S643 34668102 sHHsLAssLRSHHTH Dsh_C X X +NEK2 NEK2 P51955 human FANCA 2175 O15360 FANCA human T351 11076033 REWsFARtHPLLTsL Fanconi_A_N X X +NEK2 NEK2 P51955 human LRRC45 201255 Q96CN5 LRRC45 human S661 28850300 VLAYVQAsPVRtLsP X X +NEK2 NEK2 P51955 human NEK2 4751 P51955 NEK2 human T170 4271902 ARILNHDtsFAktFV Pkinase X +NEK2 NEK2 P51955 human SGO1 151648 Q5FBB7 SGO1 human S507 486242 TDLCFLNsPIFKQKK X X +NEK2 NEK2 P51955 human GAS2L1 10634 Q99501 GAS2L1 human S352 1974202 HPRSRRysGDsDssA X X +NEK2 NEK2 P51955 human NEK2 4751 P51955 NEK2 human S171 12574604 RILNHDtsFAktFVG Pkinase X +NEK2 NEK2 P51955 human NEK2 4751 P51955 NEK2 human S402 478164 MRsENsEsQLtsksK X +NEK2 NEK2 P51955 human DVL3 1857 Q92997 DVL3 human S697 4729017 VPPELTAsrQsFRMA Dsh_C X X +NEK2 NEK2 P51955 human NEK2 4751 P51955 NEK2 human S356 12574602 ENLLkNYsLLkERkF X +NEK2 NEK2 P51955 human LIP8 116840 Q8N137 CNTROB human T35 27565612 NQVSSEVtsQLYAsL X +NEK2 NEK2 P51955 human CEP250 11190 Q9BV73 CEP250 human S2064 1869636100 REQLLEksLAQRVQE X +NEK2 NEK2 P51955 human PPP1CC 5501 P36873 PPP1CC human T307 3190033 EKKkPNAtRPVtPPR X +NEK2 NEK2 P51955 human PD-L1 29126 Q9NZQ7 CD274 human T194 1874101908 EEKLFNVtsTLRINT C2-set_2 X X +NEK2 NEK2 P51955 human DVL3 1857 Q92997 DVL3 human T15 34668103 YHLDGQEtPYLVKLP DIX X X +NEK2 NEK2 P51955 human TRF1 7013 P54274 TERF1 human S114 63083903 AIIHGLSsLTACQLR TRF X +NEK2 NEK2 P51955 human NEK2 4751 P51955 NEK2 human T175 12574603 HDtsFAktFVGtPYY Pkinase X +NEK2 NEK2 P51955 human NPM1 4869 P06748 NPM1 human S70 459898 EAMNyEGsPIkVtLA Nucleoplasmin X +NEK2 NEK2 P51955 human PD-L1 29126 Q9NZQ7 CD274 human T210 1874101910 TNEIFYCtFRRLDPE C2-set_2 X X +NEK2 NEK2 P51955 human YAP1 10413 P46937 YAP1 human T143 3190678 AVsPGtLtPtGVVsG X +NEK2 NEK2 P51955 human LIP8 116840 Q8N137 CNTROB human S36 27565611 QVSSEVtsQLYAsLR X +NEK2 NEK2 P51955 human NEK2 4751 P51955 NEK2 human T179 12574601 FAktFVGtPYYMsPE Pkinase X +NEK2 NEK2 P51955 human PPP1CC 5501 P36873 PPP1CC human T318 11379600 tPPRGMItkQAkK__ X +NEK2 NEK2 P51955 human HEC1 10403 O14777 NDC80 human S165 449867 LGYPFALsKSSMYTV Ndc80_HEC X X +NEK2 NEK2 P51955 human OLA1 29789 Q9NTK5 OLA1 human T124 1883583904 CDGIFHLtRAFEDDD X +NEK2 NEK2 P51955 human DVL3 1857 Q92997 DVL3 human S280 34668101 DGGIYIGsIMkGGAV PDZ X X +NEK2 NEK2 P51955 human CEP250 11190 Q9BV73 CEP250 human S2421 20831305 LDEsLtQsLTsPGPV X +NEK2 NEK2 P51955 human p53 7157 P04637 TP53 human S315 447530 LPNNtsssPQPkkkP X X 2528 +NEK2 NEK2 P51955 human LIP8 116840 Q8N137 CNTROB human S45 27565614 LYAsLRLsRQAEATA X +PIM1 Pim1 P11309 human LDH-A 3939 P00338 LDHA human S161 31882218 PkNrVIGsGCNLDsA X X +PIM1 Pim1 P11309 human UHRF1 iso2 29128 Q96T88-2 UHRF1 human S311 2902206 DNPMRRKsGPSCKHC X X +PIM1 Pim1 P11309 human CAPZA1 829 P52907 CAPZA1 human S126 1870026100 SWREsCDsALRAYVk F-actin_cap_A X X +PIM1 Pim1 P11309 human 4E-BP1 13685 Q60876 Eif4ebp1 mouse S64 447527 FLMECRNsPVAKtPP eIF_4EBP X 9451; 9456 +PIM1 Pim1 P11309 human p21Cip1 1026 P38936 CDKN1A human S146 447836 GRkRRQtsMTDFyHs X +PIM1 Pim1 P11309 human DRP1 10059 O00429 DNM1L human S637 483971 VPVARKLsAREQRDC X 4867; 6319 +PIM1 Pim1 P11309 human MARK3 iso3 4140 P27448-3 MARK3 human T95 3597305 DKtQLNPtsLQKLFR Pkinase X +PIM1 Pim1 P11309 human CBX8 57332 Q9HC52 CBX8 human S196 1874101936 PssPGDSsKKRGPKP X X +PIM1 Pim1 P11309 human NFAT2 4772 O95644 NFATC1 human S245 448861 PSTsPRAsVTEEsWL X +PIM1 Pim1 P11309 human AML2 864 Q13761 RUNX3 human T155 6097703 ksFtLtItVFTNPTQ Runt X +PIM1 Pim1 P11309 human NFAT2 4772 O95644 NFATC1 human S269 448862 PCNKRKYsLNGRQPP X +PIM1 Pim1 P11309 human 14-3-3 zeta 7534 P63104 YWHAZ human S64 10407031 ssWRVVssIEQkTEG 14-3-3 X X +PIM1 Pim1 P11309 human DEPDC5 9681 O75140 DEPDC5 human S1530 3845300 QQRRRRNstSSTNQN DEPDC5_CTD X +PIM1 Pim1 P11309 human p27Kip1 1027 P46527 CDKN1B human T157 448645 GIRkrPAtDDSSTQN X X +PIM1 Pim1 P11309 human NKX3-1 4824 Q99801 NKX3-1 human S186 7998431 TKRkQLssELGDLEK X +PIM1 Pim1 P11309 human MDM2 4193 Q00987 MDM2 human S186 448131 RQRkRHksDsIsLsF X X +PIM1 Pim1 P11309 human H3 8350 P68431 H3C1 human S10 455676 tkQtArkstGGkAPr Histone X X 9701; 9711; 9606; 3465; 3642; 3377; 3475; 3458; 5764; 47398; 8481; 8552; 53348; 29237; 66065; 43185; 64522; 52725 +PIM1 Pim1 P11309 human NFAT2 4772 O95644 NFATC1 human T154 1869090801 SSKRsPstATLsLPs X +PIM1 Pim1 P11309 human ABCG2 9429 Q9UNQ0 ABCG2 human T362 1818104 GEkKKKItVFKEISY X +PIM1 Pim1 P11309 human SKP2 6502 Q13309 SKP2 human T417 15165300 WGIkCRLtLQkPSCL X +PIM1 Pim1 P11309 human LKB1 6794 Q15831 STK11 human S334 448146 DTKDRWRsMtVVPYL X X 3055 +PIM1 Pim1 P11309 human NFAT2 4772 O95644 NFATC1 human S151 56629000 VLPSSKRsPstATLs X +PIM1 Pim1 P11309 human STAT5B 6777 P51692 STAT5B human S731 448751 TyMDQAPsPAVCPQA X +PIM1 Pim1 P11309 human S6 20104 P62754 Rps6 mouse S235 448092 IAKRRRLssLRAsts X 5006; 4856; 4857; 4858; 4851; 4803; 2211; 3945; 3985; 5316; 4854; 8520; 48319; 40643; 9865; 38573; 14733; 27036; 34411; 62016; 62788; 81736; 97935; 99457; 15448 +PIM1 Pim1 P11309 human AR 367 P10275 AR human T851 5204777 ACkRkNPtSCSRRFy Hormone_recep X X +PIM1 Pim1 P11309 human NKX3-1 4824 Q99801 NKX3-1 human S195 4913200 LGDLEKHssLPALKE X +PIM1 Pim1 P11309 human BAD 12015 Q61337 Bad mouse S112 447860 ETRsRHssyPAGtEE Bcl-2_BAD X X 9291; 5284; 9296; 5193; 11865; 94223 +PIM1 Pim1 P11309 human NKX3-1 4824 Q99801 NKX3-1 human S196 4825100 GDLEKHssLPALKEE X +PIM1 Pim1 P11309 human NFAT2 4772 O95644 NFATC1 human S153 1869090803 PSSKRsPstATLsLP X +PIM1 Pim1 P11309 human NFAT2 4772 O95644 NFATC1 human T339 1869090805 PVKsRkttLEQPPsV X +PIM1 Pim1 P11309 human Myc 4609 P01106 MYC human S308 10852562 GHskPPHsPLVLkrC Myc_N X +PIM1 Pim1 P11309 human AR 367 P10275 AR human S215 448577 SGRAREAsGAPtsSK Androgen_recep X X +PIM1 Pim1 P11309 human p21Cip1 1026 P38936 CDKN1A human T145 447837 QGRkRRQtsMTDFyH X X +PIM1 Pim1 P11309 human LDH-A 3939 P00338 LDHA human S319 24986816 EEARLkksADtLWGI Ldh_1_C X +PIM1 Pim1 P11309 human CXCR4 12767 P70658 Cxcr4 mouse S346 458320 GKRGGHssVsTESEs X 59028 +PIM1 Pim1 P11309 human HBP1 26959 O60381 HBP1 human S372 63253100 SAVYVLSsMARQRrA X X +PIM1 Pim1 P11309 human NFAT2 4772 O95644 NFATC1 human S335 1869090800 GDGVPVKsRkttLEQ X +PIM1 Pim1 P11309 human CAPZB iso1 832 P47756-1 CAPZB human S226 27445587 DMENkIRsTLNEIyF F_actin_cap_B X X +PIM1 Pim1 P11309 human NKX3-1 4824 Q99801 NKX3-1 human S185 4825101 KTKRkQLssELGDLE X +PIM1 Pim1 P11309 human SKP2 6502 Q13309 SKP2 human S64 457412 sNLGHPEsPPRkRLk X 14865 +PIM1 Pim1 P11309 human BAD 12015 Q61337 Bad mouse S155 447863 GRELRRMsDEFEGsF Bcl-2_BAD X X 9297 +PIM1 Pim1 P11309 human EIF4B 1975 P23588 EIF4B human S406 470374 RPRERHPsWRsEEtQ X 8151; 5399 +PIM1 Pim1 P11309 human SKP2 6502 Q13309 SKP2 human S72 480507 PPRkRLkskGsDkDF X +PIM1 Pim1 P11309 human Myc 17869 P01108 Myc mouse S344 2750300 AkRAKLDsGRVLKQI Myc_N X X +PIM1 Pim1 P11309 human ASK1 4217 Q99683 MAP3K5 human S83 447735 ATRGRGssVGGGSrR X X 3761 +PIM1 Pim1 P11309 human BAD 572 Q92934 BAD human S75 447860 EIRsRHssyPAGtED Bcl-2_BAD X 9291; 5284; 9296; 5193; 11865; 94223 +PIM1 Pim1 P11309 human AR 367 P10275 AR human S220 1875072200 EAsGAPtsSKDNyLG Androgen_recep X +PIM1 Pim1 P11309 human AML2 864 Q13761 RUNX3 human S149 6097701 GRSGRGksFtLtItV Runt X +PIM1 Pim1 P11309 human Oct4 5460 Q01860 POU5F1 human S288 22830416 RRQKGKRsssDyAQR X +PIM1 Pim1 P11309 human IRS1 3667 P35568 IRS1 human S1101 453434 GCRRRHssEtFsStP X X +PIM1 Pim1 P11309 human Abi-2 10152 Q9NYB9 ABI2 human S183 4710620 PPtQKPPsPPMsGKG X X +PIM1 Pim1 P11309 human MDM2 4193 Q00987 MDM2 human S166 448130 SsRRRAIsEtEENsD X X 3521 +PIM1 Pim1 P11309 human FOXO3A 2309 O43524 FOXO3 human T32 448602 QsRPRsCtWPLQRPE X 2599; 9464 +PIM1 Pim1 P11309 human CAPZB iso1 832 P47756-1 CAPZB human T186 14571038 tNKsGsGtMNLGGsL F_actin_cap_B X X +PIM1 Pim1 P11309 human eNOS 4846 P29474 NOS3 human S633 448637 WRRKRKEssNtDsAG Flavodoxin_1 X X +PIM1 Pim1 P11309 human IRS2 8660 Q9Y4H2 IRS2 human S1149 453435 GGRRRHssEtFSsTt X 2385 +PIM1 Pim1 P11309 human p27Kip1 1027 P46527 CDKN1B human T198 448781 PGLRRRQt_______ X X +PIM1 Pim1 P11309 human HIF1A 3091 Q16665 HIF1A human T455 31887953 LAMsPLPtAEtPkPL X X +PIM1 Pim1 P11309 human NFAT2 4772 O95644 NFATC1 human S256 1869090802 EsWLGARssRPAsPC X +PIM1 Pim1 P11309 human HBP1 26959 O60381 HBP1 human S380 3252925 MARQRrAsLsCGGPG X X +PIM1 Pim1 P11309 human Notch 1 18128 Q01705 Notch1 mouse S2152 3252805 GkkARkPsTkGLACG X X +PIM1 Pim1 P11309 human PSMD2 5708 Q13200 PSMD2 human S361 487471 ENNrFGGsGsQVDsA X X +PIM1 Pim1 P11309 human AML2 864 Q13761 RUNX3 human T151 6097702 SGRGksFtLtItVFT Runt X +PIM1 Pim1 P11309 human MARK3 iso3 4140 P27448-3 MARK3 human T90 3597303 AIKIIDKtQLNPtsL Pkinase X +PIM1 Pim1 P11309 human CAPZA1 829 P52907 CAPZA1 human S106 27445584 DHLRkEAsDPQPEEA F-actin_cap_A X X +PIM1 Pim1 P11309 human NFkB-p65 5970 Q04206 RELA human S276 447798 sMQLRRPsDRELsEP RHD_dimer X X +PIM1 Pim1 P11309 human NDRG1 10397 Q92597 NDRG1 human S330 452879 LMRsRtAsGssVtsL X 3506; 11899 +PIM1 Pim1 P11309 human NFAT2 4772 O95644 NFATC1 human S257 40512526 sWLGARssRPAsPCN X +PIM1 Pim1 P11309 human HIF2A 2034 Q99814 EPAS1 human S435 1874020200 GKAILPPsQPWATEL X +PIM1 Pim1 P11309 human NFAT2 4772 O95644 NFATC1 human T338 1869090804 VPVKsRkttLEQPPs X +PIM1 Pim1 P11309 human CAPZB iso1 832 P47756-1 CAPZB human S192 23090287 GtMNLGGsLtRQMEk F_actin_cap_B X X +PIM1 Pim1 P11309 human Oct4 5460 Q01860 POU5F1 human S289 22830418 RQKGKRsssDyAQRE X +PIM1 Pim1 P11309 human CXCR4 7852 P61073 CXCR4 human S339 458320 GkrGGHssVstEsEs X 59028 +PIM1 Pim1 P11309 human NKX3-1 4824 Q99801 NKX3-1 human T89 464287 AAPEEAEtLAEtEPE X +PIM1 Pim1 P11309 human MARK3 iso3 4140 P27448-3 MARK3 human S96 3597304 KtQLNPtsLQKLFRE Pkinase X +PIM1 Pim1 P11309 human AML2 864 Q13761 RUNX3 human T153 6097700 RGksFtLtItVFTNP Runt X +PIM1 Pim1 P11309 human BAD 12015 Q61337 Bad mouse S136 447862 PFRGRsRsAPPNLWA Bcl-2_BAD X X 9295; 5286; 4366 +PIM1 Pim1 P11309 human FOXO3A 2309 O43524 FOXO3 human S253 449108 APRRRAVsMDNSNkY X 9466; 13129 +PIM1 Pim1 P11309 human S6 20104 P62754 Rps6 mouse S236 448093 AKRRRLssLRAstsK X 5006; 4856; 4857; 4858; 4851; 4803; 2211; 3945; 3985; 5316; 4854; 8520; 48319; 40643; 9865; 38573; 14733; 27036; 34411; 62016; 62788; 81736; 97935; 99457; 15448 +PIM1 Pim1 P11309 human NFAT2 4772 O95644 NFATC1 human S278 41453273 NGRQPPYsPHHsPTP X +PIM1 Pim1 P11309 human FOXP3 50943 Q9BZS1 FOXP3 human S422 35517300 KkRsQRPsRCSNPTP X X +STK4 MST1 Q13043 human TNNI3 7137 P19429 TNNI3 human T129 6796400 ITEIADLtQkIFDLR Troponin X X +STK4 MST1 Q13043 human PRDX1 5052 Q06830 PRDX1 human T183 476233 GWkPGsDtIkPDVQk 1-cysPrx_C X +STK4 MST1 Q13043 human GR 2908 P04150 NR3C1 human S682 1872513508 VPkDGLksQELFDEI Hormone_recep X +STK4 MST1 Q13043 human GJA1 2697 P17302 GJA1 human S255 448852 HAtsGALsPAkDCGs X X +STK4 MST1 Q13043 human MST1 6789 Q13043 STK4 human T183 447925 DtMAkRNtVIGTPFW Pkinase X X 3681; 49332 +STK4 MST1 Q13043 human FOXO1A 2308 Q12778 FOXO1 human S212 4258803 SSAGWkNsIRHNLsL Forkhead X +STK4 MST1 Q13043 human Abl 25 P00519 ABL1 human T735 450291 DTEWRSVtLPRDLQS X 2864 +STK4 MST1 Q13043 human FOXO1A 2308 Q12778 FOXO1 human S218 4258805 NsIRHNLsLHSkFIR Forkhead X +STK4 MST1 Q13043 human GR 2908 P04150 NR3C1 human T562 1872513501 StWRIMTtLNMLGGR Hormone_recep X +STK4 MST1 Q13043 human MOB1A 55233 Q9H8S9 MOB1A human T35 3212769 LLkHAEAtLGsGNLR Mob1_phocein X X 8699 +STK4 MST1 Q13043 human Bcl-xL 12048 Q64373 Bcl2l1 mouse S14 33668512 ELVVDFLsYKLSQKG BH4 X X +STK4 MST1 Q13043 human LC3B 67443 Q9CQV6 Map1lc3b mouse T50 37045604 QLPVLDktkFLVPDH ATG8 X X +STK4 MST1 Q13043 human AMPKA1 5562 Q13131 PRKAA1 human T183 448786 sDGEFLRtsCGsPNy Pkinase X 2535; 2531; 4188; 5256; 50081; 74281 +STK4 MST1 Q13043 human H2B 3018 P33778 H2BC3 human S14 449904 APAPkkGskkAItkA Histone X X 6959 +STK4 MST1 Q13043 human NDR1 11329 Q15208 STK38 human T444 460659 DWVFINytyKRFEGL Pkinase_C X +STK4 MST1 Q13043 human LATS2 305922 NP_001100737 Lats2 rat T999 31843001 EHAFYEFtFRRFFDD Pkinase_C X 8654 +STK4 MST1 Q13043 human TNNI3 7137 P19429 TNNI3 human T143 451483 RGKFKRPtLRrVrIs Troponin X X +STK4 MST1 Q13043 human MST1 6789 Q13043 STK4 human T353 64227000 TMTDGANtMIEHDDt X +STK4 MST1 Q13043 human FOXO3A 2309 O43524 FOXO3 human S243 464652 INPDGGksGkAPRRR Forkhead X +STK4 MST1 Q13043 human FOXO3A 2309 O43524 FOXO3 human S209 464289 SSAGWkNsIRHNLsL Forkhead X X +STK4 MST1 Q13043 human GR 2908 P04150 NR3C1 human T668 1872513506 EEYLCMKtLLLLSSV Hormone_recep X +STK4 MST1 Q13043 human LATS1 9113 O95835 LATS1 human T1079 457595 EHAFyEFtFRRFFDD X 8654 +STK4 MST1 Q13043 human UNC5B 219699 Q8IZJ1 UNC5B human T428 1870414700 FHPVNFKtARPSNPQ X +STK4 MST1 Q13043 human beclin 1 8678 Q14457 BECN1 human T108 29606706 GEASDGGtMENLSRR BH3 X X +STK4 MST1 Q13043 human PRDX1 5052 Q06830 PRDX1 human T90 455554 CHLAWVNtPkkQGGL AhpC-TSA X +STK4 MST1 Q13043 human LATS1 308265 F1M2K4 Lats1 rat T1079 457595 EHAFYEFtFRRFFDD X 8654 +STK4 MST1 Q13043 human FOXO3A 2309 O43524 FOXO3 human S231 465447 QNEGTGKssWWIINP Forkhead X +STK4 MST1 Q13043 human IRF3 3661 Q14653 IRF3 human T75 55458201 RDkPDLPtWkRNFRs IRF X X +STK4 MST1 Q13043 human YAP1 22601 P46938 Yap1 mouse S112 448847 PQHVRAHssPAsLQL X 4911; 13008; 92367; 57706 +STK4 MST1 Q13043 human MST1 58231 Q9JI11 Stk4 mouse S327 447924 sEEDEMDsGtMVRAA X +STK4 MST1 Q13043 human FOXO1A 2308 Q12778 FOXO1 human S235 4258802 NEGTGKssWWMLNPE Forkhead X +STK4 MST1 Q13043 human GR 2908 P04150 NR3C1 human S746 1872513507 TFLDKTMsIEFPEML X +STK4 MST1 Q13043 human AurB 9212 Q96GD4 AURKB human T232 450325 APsLRRktMCGtLDy Pkinase X 2914; 13464; 8525 +STK4 MST1 Q13043 human FOXO1A 2308 Q12778 FOXO1 human S234 4258804 QNEGTGKssWWMLNP Forkhead X +STK4 MST1 Q13043 human FOXO3A 2309 O43524 FOXO3 human S232 465448 NEGTGKssWWIINPD Forkhead X +STK4 MST1 Q13043 human TNNI3 7137 P19429 TNNI3 human T31 6796401 sNyRAyAtEPHAKKK Troponin-I_N X X +STK4 MST1 Q13043 human LC3B 81631 Q9GZQ8 MAP1LC3B human T50 37045604 QLPVLDktkFLVPDH ATG8 X X +STK4 MST1 Q13043 human Nur77 3164 P22736 NR4A1 human T366 1881000304 AsPANLLtSLVRAHL X X +STK4 MST1 Q13043 human FOXO3A 2309 O43524 FOXO3 human S215 464651 NsIRHNLsLHSRFMR Forkhead X +STK4 MST1 Q13043 human MOB1B 92597 Q7L9L4 MOB1B human T35 3545001 LLkHAEAtLGsGNLR Mob1_phocein X 8699 +STK4 MST1 Q13043 human ITGA2 3673 P17301 ITGA2 human S1180 3181118 IDETtELss______ X +STK4 MST1 Q13043 human MST1 6789 Q13043 STK4 human T367 7445972 tLPSQLGtMVINAED X +STK4 MST1 Q13043 human QSK 23387 Q9Y2K2 SIK3 human T221 456036 TPGQLLKtWCGSPPY Pkinase X +STK4 MST1 Q13043 human PRDX1 5052 Q06830 PRDX1 human T18 17401748 PAPNFkAtAVMPDGQ AhpC-TSA X +STK4 MST1 Q13043 human H2AX 3014 P16104 H2AX human S139 448841 GkkAtQAsQEy____ X X 2577; 9719; 9720; 9718; 4309; 5763; 5438; 93629; 80312; 20304; 85410; 97148; 60566; 59141 +STK4 MST1 Q13043 human TNNI3 7137 P19429 TNNI3 human T51 6796402 sRKLQLKtLLLQIAK Troponin X X +STK4 MST1 Q13043 human MOB1B 92597 Q7L9L4 MOB1B human T12 3545000 FGsRssktFKPkkNI X 8843 +STK4 MST1 Q13043 human FOXO1A 84482 G3V7R4 Foxo1 rat S206 4258803 SSAGWKNsIRHNLSL Forkhead X X +STK4 MST1 Q13043 human IRF3 3661 Q14653 IRF3 human T253 55458200 PDPGMSLtDRGVMsY IRF-3 X X +STK4 MST1 Q13043 human L-plastin 18826 Q61233 Lcp1 mouse T89 3851696 KSTEVAKtFRKAINK X X +Ripk3 RIPK3 Q9QZL0 mouse MLKL 74568 Q9D2Y4 Mlkl mouse T349 8148779 TQNsIsRtAKSTKAE PK_Tyr_Ser-Thr X +Ripk3 RIPK3 Q9QZL0 mouse AMPKA1 105787 Q5EG47 Prkaa1 mouse T183 448786 sDGEFLRtsCGsPNY Pkinase X 2535; 2531; 4188; 5256; 50081; 74281 +Ripk3 RIPK3 Q9QZL0 mouse RIPK3 56532 Q9QZL0 Ripk3 mouse S232 23003800 AELVDKtsLIRETVC Pkinase X X 57220; 91702 +Ripk3 RIPK3 Q9QZL0 mouse MLKL 74568 Q9D2Y4 Mlkl mouse S345 22996309 ELSKTQNsIsRtAKS PK_Tyr_Ser-Thr X X 37333; 17825 +Ripk3 RIPK3 Q9QZL0 mouse CAMK2D 108058 Q6PHZ2 Camk2d mouse T287 450982 sMMHRQEtVDCLkkF X 12716 +Ripk3 RIPK3 Q9QZL0 mouse RIPK3 56532 Q9QZL0 Ripk3 mouse T231 27928506 EAELVDKtsLIRETV Pkinase X X 57220; 91702 +Ripk3 RIPK3 Q9QZL0 mouse MLKL 74568 Q9D2Y4 Mlkl mouse S347 29611200 SKTQNsIsRtAKSTK PK_Tyr_Ser-Thr X +MOS MOS P00540 human Vimentin 7431 P08670 VIM human S459 470128 GQVINEtsQHHDDLE X +MOS MOS P00540 human Vimentin 7431 P08670 VIM human T458 471089 DGQVINEtsQHHDDL X +MOS MOS P00540 human MEK1 100009316 P29678 MAP2K1 rabbit S218 448514 VSGQLIDsMANsFVG Pkinase X 9121; 3958; 9154; 86128 +MOS MOS P00540 human MEK1 100009316 P29678 MAP2K1 rabbit S222 448513 LIDsMANsFVGTRSY Pkinase X 2338; 9121; 3958; 9154; 16211; 86128; 16780; 75262 +MOS MOS P00540 human MOS 17451 P00536 Mos mouse S3 448658 _____MPsPLSLCRY X +Tec TEC P24604 mouse MAF 17132 P54843 Maf mouse Y21 25673104 TSPLAMEyVNDFDLM X +Tec TEC P24604 mouse MAF 17132 P54843 Maf mouse Y131 25673103 LQGGFDGyARGAQQL X +Tec TEC P24604 mouse MAF 17132 P54843 Maf mouse Y92 25673105 KAHLEDYyWMTGYPQ Maf_N X +Prkcz PKCZ Q02956 mouse PRKD1 18760 Q62101 Prkd1 mouse S744 448589 ARIIGEksFRRsVVG Pkinase X 2054 +Prkcz PKCZ Q02956 mouse NR0B2 23957 Q62227 Nr0b2 mouse T58 28702400 RLCAPHRtCREALDV Hormone_recep X +Prkcz PKCZ Q02956 mouse CBP 12914 P45481 Crebbp mouse S436 447689 CLPLKNAsDKRNQQT X +Prkcz PKCZ Q02956 mouse AS160 210789 Q8BYJ6 Tbc1d4 mouse S595 455920 RMRGRLGsMDsFERA X 8730 +Prkcz PKCZ Q02956 mouse PAR3-alpha 81918 Q9Z340 Pard3 rat S827 467266 REGFGRQsMSEKRtK X +Prkcz PKCZ Q02956 mouse PRKD1 18760 Q62101 Prkd1 mouse S748 448590 GEksFRRsVVGtPAy Pkinase X 2054 +Prkcz PKCZ Q02956 mouse PIN1 23988 Q9QUR7 Pin1 mouse S16 447772 PGWEkRMsRSSGRVY WW X X +Prkcz PKCZ Q02956 mouse DAB2 13132 P98078 Dab2 mouse S24 451211 QAAPKAPsKKEKKKG X +Prkcz PKCZ Q02956 mouse SQSTM1 18412 Q64337 Sqstm1 mouse S351 14580829 SsKEVDPsTGELQsL X 95697; 16177; 12074 +Prkcz PKCZ Q02956 mouse P70S6KB 6199 Q9UBS0 RPS6KB2 human S473 450071 PPSGTKKsKRGRGRP X +Prkcz PKCZ Q02956 mouse CTNNB1 12387 Q02248 Ctnnb1 mouse S45 447488 GATtTAPsLsGkGNP X 9565; 9564; 24710; 70034; 19807; 96727; 77605 +Prkcz PKCZ Q02956 mouse TRAF2 22030 P39429 Traf2 mouse T117 471341 DGCTWKGtLKEYESC X X +Prkcz PKCZ Q02956 mouse PKCZ 18762 Q02956 Prkcz mouse T560 447572 TSEPVQLtPDDEDVI Pkinase_C X +Prkcz PKCZ Q02956 mouse NFkB-p65 19697 Q04207 Rela mouse S311 449966 RTYETFksIMKKSPF X X +Prkcz PKCZ Q02956 mouse JAM-A 16456 O88792 F11r mouse S285 467829 kVIysQPstRsEGEF X +Prkcz PKCZ Q02956 mouse NUMB 18222 Q9QZS3 Numb mouse S295 470030 sPFKRQLsLRINELP NumbF X +TRIB2 TRB2 Q92519 human PKM 5315 P14618 PKM human S37 476070 MCRLDIDsPPItARN X X + TGFBR2 no information TGFBR1 7046 P36897 TGFBR1 human Y182 7791190 TtLkDLIyDMttsGs TGF_beta_GS X +MAP4K3 KHS2 Q8IVH8 human ACE2 59272 Q9BYF1 ACE2 human S783 23078777 sGENPyAsIDIsKGE X X +MAP4K3 KHS2 Q8IVH8 human TFEB 7942 P19484 TFEB human S3 54467500 _____MAsRIGLrMQ X +MAP4K3 KHS2 Q8IVH8 human KHS2 8491 Q8IVH8 MAP4K3 human S170 12655400 AtIAkRKsFIGTPYW Pkinase X X +MAP4K3 KHS2 Q8IVH8 human IQGAP1 8826 P46940 IQGAP1 human S480 1869135500 NTVWKQLsSSVTGLT X X +MAP4K3 KHS2 Q8IVH8 human PKCT 5588 Q04759 PRKCQ human T538 447907 LGDAktNtFCGtPDy Pkinase X X 9379; 9377; 2060; 38938 +MAP4K3 KHS2 Q8IVH8 human ACE2 59272 Q9BYF1 ACE2 human S776 1880091000 KkkNkARsGENPyAs X X +MAP4K3 KHS2 Q8IVH8 human IKKB 3551 O14920 IKBKB human S733 5014908 TVREQDQsFtALDWs IKKbetaNEMObind X X +Prkg1 PKG1 iso2 P0C605-2 mouse VASP 22323 P70460 Vasp mouse S153 448379 EHMERRVsNAGGPPA X X 3111; 84519 +Prkg1 PKG1 iso2 P0C605-2 mouse Lasp-1 16796 Q61792 Lasp1 mouse T156 454432 SSSYRRPtEQQQPQP X +FAM20C FAM20C Q8IXL6 human FGF23 8074 Q9GZV9 FGF23 human S180 33365504 IPRRHtRsAEDDSER X X +FAM20C FAM20C Q8IXL6 human PDIA1 5034 P07237 P4HB human S357 56652490 KIKPHLMsQELPEDW X +FAM20C FAM20C Q8IXL6 human FETUA 197 P02765 AHSG human S330 467425 VVsLGsPsGEVsHPR X +FAM20C FAM20C Q8IXL6 human FAM20C 56975 Q8IXL6 FAM20C human S106 1874398900 SsNLSSHsLEKLPPA X +FAM20C FAM20C Q8IXL6 human 7B2 25719 P27682 Scg5 rat T97 40411700 PNIVAELtGDNIPKD Secretogranin_V X +FAM20C FAM20C Q8IXL6 human PCSK9 255738 Q8NBP7 PCSK9 human S47 2811403 ELVLALRsEEDGLAE X X +FAM20C FAM20C Q8IXL6 human VWF 7450 P04275 VWF human S1517 1867984204 GEADFNRsKEFMEEV VWA X +FAM20C FAM20C Q8IXL6 human HRC 3270 P23327 HRC human S96 34499322 EKEDEDVsKEyGHLL X +FAM20C FAM20C Q8IXL6 human PCSK7 9159 Q16549 PCSK7 human S505 1827354800 AIPQSPRsLEVLWNV X +FAM20C FAM20C Q8IXL6 human 7B2 25719 P27682 Scg5 rat T135 25728419 CLENAPDtAEFsREF Secretogranin_V X +FAM20C FAM20C Q8IXL6 human ERO1L 30001 Q96HE7 ERO1A human S145 36122817 GAVDEsLsEETQkAV ERO1 X +FAM20C FAM20C Q8IXL6 human VWF 7450 P04275 VWF human S1613 1867984205 MVTGNPAsDEIKRLP VWA X +Mapk14 P38A P47811 mouse ULK1 22241 O70405 Ulk1 mouse S757 483139 PVVFtVGsPPsGAtP X 14202; 6888; 29313 +Mapk14 P38A P47811 mouse ATG5 11793 Q99J83 Atg5 mouse T75 27138202 IWFEYEGtPLKWHYP X +Mapk14 P38A P47811 mouse FOXO1A 56458 Q9R1E0 Foxo1 mouse S475 478372 PPHNDIMsPVDPGVA FOXO_KIX_bdg X X +Mapk14 P38A P47811 mouse hnRNP H1 59013 O35737 Hnrnph1 mouse S104 455395 LKHtGPNsPDtANDG X +Mapk14 P38A P47811 mouse ATF-2 1386 P15336 ATF2 human T69 448224 sVIVADQtPtPtRFL X 9225; 94125; 40749; 61584; 44167 +Mapk14 P38A P47811 mouse FOXO1A 56458 Q9R1E0 Foxo1 mouse S326 448076 stISGRLsPIMtEQD X +Mapk14 P38A P47811 mouse ATF-2 1386 P15336 ATF2 human T71 448225 IVADQtPtPtRFLkN X 9225; 9221; 5112; 94125; 13850; 40749; 15411; 24329; 61584; 27934; 92109; 20534; 35858 +Mapk14 P38A P47811 mouse K8 16691 P11679 Krt8 mouse S80 448539 TVNQSLLsPLkLEVD Keratin_2_head X +Mapk14 P38A P47811 mouse P38A 26416 P47811 Mapk14 mouse T180 447970 RHtDDEMtGyVAtRW Pkinase X 9211; 9215; 4551; 9216; 4552; 4631; 4511; 4092; 9219; 24678; 8632; 6908; 41768; 51255; 14594; 14598; 62979 +Mapk14 P38A P47811 mouse PSMD1 5707 Q99460 PSMD1 human T273 452931 QNLRtVGtPIAsVPG X X +Mapk14 P38A P47811 mouse K8 16691 P11679 Krt8 mouse S438 448540 sSYGGLTsPGFSYGM X +Mapk14 P38A P47811 mouse FOXO1A 56458 Q9R1E0 Foxo1 mouse S429 478370 TYGQSSMsPLPQMPM FOXO_KIX_bdg X +Mapk14 P38A P47811 mouse Myf-6 17878 P15375 Myf6 mouse S31 2907504 PLEVAEGsPLYPGSD Basic X +Mapk14 P38A P47811 mouse FOXO1A 56458 Q9R1E0 Foxo1 mouse T557 478373 NRLtPVKtPLQVPLS X +Mapk14 P38A P47811 mouse PRDX6 11758 O08709 Prdx6 mouse T93 484030 INAyNGEtPTEkLPF AhpC-TSA X X +Mapk14 P38A P47811 mouse GR 2908 P04150 NR3C1 human S134 3178932 ANLNRstsVPENPkS GCR X 85060 +Mapk14 P38A P47811 mouse MITF iso8 17342 Q08874-8 Mitf mouse S307 451221 IPSTGLCsPDLVNRI DUF3371 X X +Mapk14 P38A P47811 mouse TAB3 257397 Q8N5C8 TAB3 human T404 1295506 HSLYTATtPPSssPS X +Mapk14 P38A P47811 mouse XBP1 22433 O35426 Xbp1 mouse S61 21688102 RQRLTHLsPEEKALR bZIP_1 X +Mapk14 P38A P47811 mouse RARG iso2 19411 P18911-2 Rarg mouse S68 455544 EMVPSsPsPPPPPRV X +Mapk14 P38A P47811 mouse AHNAK 66395 E9Q616 Ahnak mouse S5555 452765 KPRHRsNsFsDEREF X +Mapk14 P38A P47811 mouse osterix 170574 Q8VI67 Sp7 mouse S73 15334100 SSTNGLLsPAGsPPA X X +Mapk14 P38A P47811 mouse Kv4.2 16508 Q9Z0V2 Kcnd2 mouse T607 457612 IPtPPVttPEGDDRP X +Mapk14 P38A P47811 mouse Myf-6 17878 P15375 Myf6 mouse S42 2907503 PGSDGTLsPCQDQMP Basic X +Mapk14 P38A P47811 mouse GATA3 14462 P23772 Gata3 mouse S308 456464 IKPKRRLsAARRAGT X +Mapk14 P38A P47811 mouse STAT3 20848 P42227 Stat3 mouse S727 448191 NtIDLPMsPRTLDSL X 9134; 9136; 34911; 94994; 49081; 58978; 87544; 71958; 50804 +Mapk14 P38A P47811 mouse ATF-2 11909 P16951 Atf2 mouse T51 448224 sVIVADQtPtPtRFL X X 9225; 94125; 40749; 61584; 44167 +Mapk14 P38A P47811 mouse PARK2 50873 Q9WVS6 Prkn mouse S131 454421 DTDSKRDsEAARGPV X +Mapk14 P38A P47811 mouse FOXO1A 56458 Q9R1E0 Foxo1 mouse S413 478368 PPNTSLNsPsPNYSK X +Mapk14 P38A P47811 mouse p53 22059 P02340 Tp53 mouse S18 447490 IsLELPLsQEtFsGL P53_TAD X X 9284; 9286; 12571; 56979 +Mapk14 P38A P47811 mouse p21Cip1 1026 P38936 CDKN1A human S130 455618 sGEQAEGsPGGPGDs X +Mapk14 P38A P47811 mouse AHNAK 66395 E9Q616 Ahnak mouse S5566 3148527 EREFsAPstPtGtLE X +Mapk14 P38A P47811 mouse hnRNP H2 56258 P70333 Hnrnph2 mouse S104 455396 LKHtGPNsPDtANDG X +Mapk14 P38A P47811 mouse osterix 170574 Q8VI67 Sp7 mouse S77 15334101 GLLsPAGsPPAPASG X X +Mapk14 P38A P47811 mouse IWS1 73473 Q8C1D8 Iws1 mouse S183 4756568 EPPKPRIsDsEsEEL X X +Mapk14 P38A P47811 mouse H3 iso3 15081 P84244 H3f3b mouse S28 455677 ATkAArksAPSTGGV Histone X 9713 +Mapk14 P38A P47811 mouse Myb 17863 P06876 Myb mouse T486 1308921 PLKMLPQtPSHAVED Cmyb_C X +Mapk14 P38A P47811 mouse STAT4 20849 P42228 Stat4 mouse S722 447789 PSDLLPMsPSAYAVL X X +Mapk14 P38A P47811 mouse RARG iso2 19411 P18911-2 Rarg mouse S66 455543 SEEMVPSsPsPPPPP X +Mapk14 P38A P47811 mouse NFAT3 73181 Q8K120 Nfatc4 mouse S170 448860 GGAFFsPsPGSSSLS X +Mapk14 P38A P47811 mouse E2A 21423 P15806 Tcf3 mouse S140 455905 LSsPGPLsPSGIKSS X X +Mapk14 P38A P47811 mouse PGRMC1 53328 O55022 Pgrmc1 mouse S181 452525 GEEPtVysDDEEPKD X X +Mapk14 P38A P47811 mouse P38A 26416 P47811 Mapk14 mouse Y182 447971 tDDEMtGyVAtRWYR Pkinase X 9211; 9215; 4551; 9216; 4552; 4631; 4511; 4092; 9219; 24678; 8632; 6908; 41768; 51255; 14594; 14598; 62979 +Mapk14 P38A P47811 mouse ATF-2 11909 P16951 Atf2 mouse T53 448225 IVADQtPtPtRFLKN X 9225; 9221; 5112; 94125; 13850; 40749; 15411; 24329; 61584; 27934; 92109; 20534; 35858 +Mapk14 P38A P47811 mouse FOXO1A 56458 Q9R1E0 Foxo1 mouse S467 478371 KELLtsDsPPHNDIM FOXO_KIX_bdg X X +Mapk14 P38A P47811 mouse XBP1 22433 O35426 Xbp1 mouse T48 21688103 AGSEASGtPQARKRQ X +Mapk14 P38A P47811 mouse Tip60 iso2 10524 Q92993-2 KAT5 human T106 10800707 VEVVsPAtPVPSETA X +Mapk14 P38A P47811 mouse ZC3H10 103284 Q8R205 Zc3h10 mouse S126 36133857 VAAGLGLsPADLPNG X +Mapk14 P38A P47811 mouse AHNAK 66395 E9Q616 Ahnak mouse S4906 7103416 VPDVDIssPGINVEA X X +Mapk14 P38A P47811 mouse CLIC1 114584 Q9Z1Q5 Clic1 mouse S146 15408945 VLDNYLTsPLPEEVD GST_C_2 X +Mapk14 P38A P47811 mouse C/EBP-beta 12608 P28033 Cebpb mouse T188 447878 sSssPPGtPSPADAK X 3084 +Mapk14 P38A P47811 mouse Mtres1 67851 Q9CQF4 Mtres1 mouse S106 457079 KEADEEDsDEETsyP X +Mapk14 P38A P47811 mouse RANBP2 19386 Q9ERU9 Ranbp2 mouse S2505 468573 KNRPGyVsEEEEDDE IR1-M X +Mapk14 P38A P47811 mouse AQP2 11827 P56402 Aqp2 mouse S261 464644 RQsVELHsPQsLPRG X +Mapk14 P38A P47811 mouse NFAT1 18019 Q60591 Nfatc2 mouse S79 628303302 CNPLASLsGEPPGRF X +Mapk14 P38A P47811 mouse FOXO1A 56458 Q9R1E0 Foxo1 mouse S284 478910 GQEGPGDsPGSQFSK X +Mapk14 P38A P47811 mouse CRYAB 12955 P23927 Cryab mouse S59 448783 PSFLRAPsWIDtGLS X +Mapk14 P38A P47811 mouse Akt1 11651 P31750 Akt1 mouse S473 447855 RPHFPQFsysAsGtA Pkinase_C X 9271; 3787; 4060; 4051; 5102; 4058; 2336; 2337; 4075; 4070; 5012; 4071; 92982; 5315; 9563; 9018; 12694; 52240; 11962; 15116; 88106; 26580; 68035; 31957; 23430; 20235 +Mapk14 P38A P47811 mouse SCN8A 29710 O88420 Scn8a rat S553 456209 SLLSIPGsPFLSRHN Na_trans_cytopl X +Mapk14 P38A P47811 mouse TAB3 257397 Q8N5C8 TAB3 human S60 1295505 yLyMEyHsPDDNRMN X +Mapk14 P38A P47811 mouse GRP78 14828 P20029 Hspa5 mouse T649 4704207 PPtGEEDtsEKDEL_ X X +Mapk14 P38A P47811 mouse FAM65A 75687 Q68FE6 Ripor1 mouse S875 4734442 PGDRHTssPEVVAED X +Mapk14 P38A P47811 mouse ASS1 11898 P16460 Ass1 mouse S219 4703613 DPAkAPNsPDVLEIE Arginosuc_synth X +Mapk14 P38A P47811 mouse NFAT3 73181 Q8K120 Nfatc4 mouse S168 448859 QGGGAFFsPsPGSSS X +Mapk14 P38A P47811 mouse Akt1 11651 P31750 Akt1 mouse T308 447856 KDGAtMKtFCGtPEy Pkinase X 5106; 2965; 9275; 4056; 5056; 13842; 13038; 43506; 48646; 86758; 80722; 77440; 80556 +Mapk14 P38A P47811 mouse FOXO1A 56458 Q9R1E0 Foxo1 mouse S295 471972 QFSKWPAsPGSHsND X +Mapk14 P38A P47811 mouse IWS1 73473 Q8C1D8 Iws1 mouse S185 453543 PKPRIsDsEsEELPK X X +Mapk14 P38A P47811 mouse Tip60 10524 Q92993 KAT5 human T158 10800707 VEVVsPAtPVPSETA X +Mapk14 P38A P47811 mouse STAT1 20846 P42225 Stat1 mouse S727 447753 tDNLLPMsPEEFDEM STAT1_TAZ2bind X 9177; 8826; 62390 +Mapk14 P38A P47811 mouse SMARCD3 66993 Q6P9Z1 Smarcd3 mouse T229 8097074 HLVEWHRtPTTQETD X +Mapk14 P38A P47811 mouse Mtres1 67851 Q9CQF4 Mtres1 mouse S116 3214449 ETsyPERsEQEEELE X +Prkcd PKCD P09215 rat PLCB3 29322 Q99JE6 Plcb3 rat S1105 448448 LDRKRNNsISEAKTR PLC-beta_C X 2484 +Prkcd PKCD P09215 rat PKCD 170538 P09215 Prkcd rat S662 447580 QtAFKGFsFVNPKYE Pkinase_C X 9371 +Prkcd PKCD P09215 rat PRKD1 85421 Q9WTQ1 Prkd1 rat S748 448590 GEKsFRRsVVGTPAY Pkinase X +Prkcd PKCD P09215 rat TNNI3 29248 P23693 Tnni3 rat S23 448423 PAPVRRRssANYRAY Troponin-I_N X 4004 +Prkcd PKCD P09215 rat 14-3-3 eta 22629 P68510 Ywhah mouse S59 450482 VVGARRSsWRVIssI 14-3-3 X 52631 +Prkcd PKCD P09215 rat 14-3-3 beta 54401 Q9CQV8 Ywhab mouse S60 450226 VVGARRSsWRVIssI 14-3-3 X 52631 +Prkcd PKCD P09215 rat TNNI3 29248 P23693 Tnni3 rat T144 451483 RGKFkRPtLRRVRIs Troponin X +Prkcd PKCD P09215 rat IRS1 25467 P35570 Irs1 rat S357 4859802 HAHRHRGssRLHPPL X +Prkcd PKCD P09215 rat VGCNL1 266760 Q6Q760 Nalcn rat S1653 1869465802 TLSDRGGsRQDAADT X +Prkcd PKCD P09215 rat PLSCR1 5359 O15162 PLSCR1 human T161 11380906 CGPSRPFtLRIIDNM Scramblase X +Prkcd PKCD P09215 rat KLF4 114505 Q923V7 Klf4 rat T400 22996305 RKRTATHtCDYAGCG zf-C2H2 X +Prkcd PKCD P09215 rat CKM 24265 P00564 Ckm rat S128 5410301 LDPNyVLssRVRTGR X +Prkcd PKCD P09215 rat 14-3-3 zeta 22631 P63101 Ywhaz mouse S58 449833 VVGARRSsWRVVSsI 14-3-3 X 52631 +Prkcd PKCD P09215 rat PRKD1 85421 Q9WTQ1 Prkd1 rat S744 448589 ARIIGEKsFRRsVVG Pkinase X +Prkcd PKCD P09215 rat GRK2 156 P25098 GRK2 human S29 447724 ATPAARAskkILLPE X +Prkcd PKCD P09215 rat Ebp1 288778 Q6AYD3 Pa2g4 rat S360 478276 ELKALLQsSASRKTQ X +Prkcd PKCD P09215 rat TNNI3 29248 P23693 Tnni3 rat S24 448424 APVRRRssANYRAYA Troponin-I_N X 4004 +Prkcd PKCD P09215 rat G-gamma 12 14701 Q9DAS9 Gng12 mouse S2 447876 ______MssktAstN X +Ilk ILK O55222 mouse ILK 16202 O55222 Ilk mouse S343 448495 SMADVKFsFQCPGRM PK_Tyr_Ser-Thr X +EPHA4 EphA4 P54764 human ephexin-1 53972 Q8CHT1 Ngef mouse Y177 455579 IEQIGLLyQEyRDKS X +EPHA4 EphA4 P54764 human EphA4 2043 P54764 EPHA4 human Y779 450858 EDDPEAAyTtRGGKI PK_Tyr_Ser-Thr X 8793; 8862 +EPHA4 EphA4 P54764 human EphA4 2043 P54764 EPHA4 human Y602 450857 tyVDPFtyEDPNQAV EphA2_TM X +EPHA4 EphA4 P54764 human GMPR 2766 P36959 GMPR human Y267 1005248 GRKLKLFyGMssDtA IMPDH X X +EPHA4 EphA4 P54764 human PAR3-alpha 81918 Q9Z340 Pard3 rat Y1080 454961 RQARERDyAEIQDFH X +EPHA4 EphA4 P54764 human PAR3-alpha 81918 Q9Z340 Pard3 rat Y1127 457508 GHLMDTLyAQVKKPR X X +EPHA4 EphA4 P54764 human EphA4 2043 P54764 EPHA4 human Y596 450856 LNQGVRtyVDPFtyE EphA2_TM X +Hck Hck P08103 mouse Hck 15162 P08103 Hck mouse Y409 448168 RIIEDNEytAREGAK PK_Tyr_Ser-Thr X X 2101; 6943; 59548; 70926; 78740; 94361; 17320 +Hck Hck P08103 mouse Abl 11350 P00520 Abl1 mouse Y393 450298 RLMTGDTytAHAGAK PK_Tyr_Ser-Thr X 2865 +Hck Hck P08103 mouse PKCD 18753 P28867 Prkcd mouse Y523 450231 EILQGLKySFSVDWW Pkinase X X +Hck Hck P08103 mouse PKCD 18753 P28867 Prkcd mouse Y311 447573 TTEsVGIyQGFEKKP X 2055 +Hck Hck P08103 mouse Hck 15162 P08103 Hck mouse Y50 448169 ANQKGPVyVPDPTSS X X +Hck Hck P08103 mouse WASP 7454 P42768 WAS human Y291 447985 AEtsKLIyDFIEDQG PBD X X +Chuk IKKA Q60680 mouse IkB-alpha 18035 Q9Z1E3 Nfkbia mouse S32 448203 LVDDRHDsGLDsMKD X 5210; 2859; 9246; 5209 +Chuk IKKA Q60680 mouse RORC iso2 19885 P51450-2 Rorc mouse S376 139835702 GCSELISsIFDFSHF Hormone_recep X +Chuk IKKA Q60680 mouse p27Kip1 12576 P46414 Cdkn1b mouse T183 23128659 DGsPNAGtVEQtPKK X +Chuk IKKA Q60680 mouse p27Kip1 12576 P46414 Cdkn1b mouse S12 9316305 RVsNGsPsLERMDAR X +Chuk IKKA Q60680 mouse p27Kip1 12576 P46414 Cdkn1b mouse S178 450208 EENVsDGsPNAGtVE X +Chuk IKKA Q60680 mouse p27Kip1 12576 P46414 Cdkn1b mouse T42 28058802 PVNHEELtRDLEKHC CDI X +Chuk IKKA Q60680 mouse IkB-alpha 18035 Q9Z1E3 Nfkbia mouse S36 448204 RHDsGLDsMKDEEYE X 5210; 9246 +Chuk IKKA Q60680 mouse IRS1 16367 P35569 Irs1 mouse S307 447558 tEsITAtsPAsMVGG X 2381 +Chuk IKKA Q60680 mouse p27Kip1 12576 P46414 Cdkn1b mouse S175 28058801 NRtEENVsDGsPNAG X +Chuk IKKA Q60680 mouse H3 iso3 15081 P84244 H3f3b mouse S10 455676 tKQTARksTGGkAPR Histone X X 9701; 9711; 9706; 3465; 3642; 3377; 3475; 3458; 5764; 47398; 8481; 8552; 53348; 29237; 66065; 43185; 64522; 52725 +Chuk IKKA Q60680 mouse NFkB-p65 19697 Q04207 Rela mouse S534 447800 sGDEDFssIADMDFS X X 4887; 3036; 3031; 4886; 3033; 4025; 5733; 13346; 76778; 31553; 80477; 73992; 87672; 83962 +SRPK2 SRPK2 P78362 human RIMS1 84556 Q9JIR4 Rims1 rat S413 450481 ARHERRHsDVALPHT X +SRPK2 SRPK2 P78362 human RIMS1 84556 Q9JIR4 Rims1 rat S1078 4725320 RPDTSLHsPERERHS X +SRPK2 SRPK2 P78362 human RIMS1 84556 Q9JIR4 Rims1 rat S287 455664 KQASRSRsEPPRERK X +SRPK2 SRPK2 P78362 human LGMN 5641 Q99538 LGMN human S226 183811000 CYYDEkRsTYLGDWY Peptidase_C13 X X +SRPK2 SRPK2 P78362 human SRPK2 20817 O54781 Srpk2 mouse T485 483237 PsHDRsRtVsAsstG X +SRPK2 SRPK2 P78362 human RIMS1 84556 Q9JIR4 Rims1 rat S447 2761601 ARVsPPEsPRARAAA X +SRPK2 SRPK2 P78362 human RIMS1 84556 Q9JIR4 Rims1 rat S1045 4725312 PRAKRGRsAESLHMT X +SRPK2 SRPK2 P78362 human acinus 22985 Q9UKV3 ACIN1 human S1180 456759 GPRsRsRsRDRRRKE RSB_motif X X +SRPK2 SRPK2 P78362 human RIMS1 84556 Q9JIR4 Rims1 rat S514 4772463 ESMLRNDsLSSDQSE X +SRPK2 SRPK2 P78362 human SRPK2 6733 P78362 SRPK2 human S494 483631 HDRSRtVsAsstGDL X +SRPK2 SRPK2 P78362 human Tau 4137 P10636 MAPT human S214 3847081 GGKERPGsKEEVDED X X +SRPK2 SRPK2 P78362 human RIMS1 84556 Q9JIR4 Rims1 rat S1066 3926128 LDRARSAsTNCLRPD X +CDK11A CDK11A iso10 Q9UQ88-10 human CDK11B iso12 984 P21127-12 CDK11B human T370 17671300 KHEYFREtPLPIDPS X X +PRKX PRKX P51817 human SMAD6 4091 O43541 SMAD6 human S435 460301 RKVPPGYsIKVFDFE MH2 X +PRKX PRKX P51817 human PKD1 5310 P98161 PKD1 human S4166 2859800 EPLPSRSsRGsKVSP X X +Camk2d CAMK2D P15791 rat SCN5A 6331 Q14524 SCN5A human T594 25244201 LHGkKNStVDCNGVV Na_trans_cytopl X +Camk2d CAMK2D P15791 rat CACNB1 50688 P54283 Cacnb1 rat T499 471963 WALSRQDtFDADTPG X +Camk2d CAMK2D P15791 rat CACNB2 iso2 116600 Q8VGC3-2 Cacnb2 rat T498 470081 RGLSRQEtFDSETQE X X +Camk2d CAMK2D P15791 rat SCN5A 6331 Q14524 SCN5A human S516 4719558 LsLTrGLsRTsMKPR Na_trans_cytopl X +Camk2d CAMK2D P15791 rat RYR2 689560 B0LPN4 Ryr2 rat S2798 448848 yNRTRRIsQTsQVsI X +Camk2d CAMK2D P15791 rat PLB 64672 P61016 Pln rat T17 448115 SAIRRAstIEMPQQA Phospholamban X 8496 +Camk2d CAMK2D P15791 rat CAMK2D 24246 P15791 Camk2d rat T287 450982 sMMHRQEtVDCLkkF X X 12716 +DYRK1A DYRK1A P85051 rabbit FOXO1A 2308 Q12778 FOXO1 human S329 448076 stIsGRLsPIMtEQD X +MAPK6 ERK3 Q16659 human SRC-3 8202 Q9Y6Q9 NCOA3 human S857 453084 PPYNRAVsLDsPVsV X X +MAPK6 ERK3 Q16659 human supervillin 6840 O95425 SVIL human S245 468887 sFtEVPRsPKHAHSS X X +MAPK6 ERK3 Q16659 human Arp3 10096 P61158 ACTR3 human S418 480945 NPVFGVMs_______ X X +MAPK6 ERK3 Q16659 human ERK3 5597 Q16659 MAPK6 human S189 448267 ySHKGHLsEGLVTkW Pkinase X +MAPK6 ERK3 Q16659 human TTRAP 51567 O95551 TDP2 human S60 52421901 EMERALNsyFEPPVE UBA_4 X +Prkg1 PKG1 P0C605 mouse KCNMA1 iso5 16531 Q08460-5 Kcnma1 mouse S873 469989 HGMLRQPsITTGVNI X X +Prkg1 PKG1 P0C605 mouse SMAD3 17127 Q8BUN5 Smad3 mouse T388 1243500 GAEYRRQtVTSTPCW MH2 X +Prkg1 PKG1 P0C605 mouse SMAD3 17127 Q8BUN5 Smad3 mouse S309 1243501 EVFAECLsDSAIFVQ MH2 X +Prkg1 PKG1 P0C605 mouse PKG1 iso2 19091 P0C605-2 Prkg1 mouse S81 51573802 RTKRQAIsAEPTAFD X +Prkg1 PKG1 P0C605 mouse RHOA 11848 Q9QUI0 Rhoa mouse S188 449035 ARRGKKKsGCLIL__ X +Prkg1 PKG1 P0C605 mouse PKG1 19091 P0C605 Prkg1 mouse T59 448837 THIGPRTtRAQGISA X +Prkg1 PKG1 P0C605 mouse GABRB1 14400 P50571 Gabrb1 mouse S434 450244 GRIRRRAsQLKVKIP Neur_chan_memb X +Prkg1 PKG1 P0C605 mouse Lasp-1 16796 Q61792 Lasp1 mouse T156 454432 SSSYRRPtEQQQPQP X +Prkg1 PKG1 P0C605 mouse BAD 12015 Q61337 Bad mouse S155 447863 GRELRRMsDEFEGsF Bcl-2_BAD X 9297 +Prkg1 PKG1 P0C605 mouse TRPC6 22068 Q61143 Trpc6 mouse T69 470868 RLTHRRQtILREKGR X +Prkg1 PKG1 P0C605 mouse KCNMA1 iso5 16531 Q08460-5 Kcnma1 mouse S1112 466425 QSSSKKSsSVHSIPS X +Prkg1 PKG1 P0C605 mouse GSBS Q8CJC8 Gsbs rat T123 2999004 KRPRRKDtPAFHVPP X +Prkg1 PKG1 P0C605 mouse PKG1 19091 P0C605 Prkg1 mouse T85 452151 RQAFRKFtKSERSKD X +Prkg1 PKG1 P0C605 mouse KCNMA1 iso5 16531 Q08460-5 Kcnma1 mouse S692 27842903 SNVKKYDsTGMFHWC X X +Prkg1 PKG1 P0C605 mouse PDE5A 242202 Q8CG03 Pde5a mouse S92 448178 GAPARKIsASEFDRP X +Prkg1 PKG1 P0C605 mouse GSBS Q8CJC8 Gsbs rat T72 2999005 KKPRRKDtPALHIPP X +Prkg1 PKG1 P0C605 mouse PKG1 iso2 19091 P0C605-2 Prkg1 mouse T58 34434401 RSVIRPAtQQAQKQs X +Prkg1 PKG1 P0C605 mouse PKG1 iso2 19091 P0C605-2 Prkg1 mouse S65 1870119329 tQQAQKQsAsTLQGE X +Prkg1 PKG1 P0C605 mouse HSP20 126393 O14558 HSPB6 human S16 450706 PSWLRRAsAPLPGLS Crystallin X 36519 +CAMK2G CAMK2G Q13555 human BAD 12015 Q61337 Bad mouse S170 447864 KGLPRPKsAGtATQM Bcl-2_BAD X +CAMK2G CAMK2G Q13555 human CAMK2G 818 Q13555 CAMK2G human S319 2874405 RNFsAAKsLLNKKsD X +CAMK2G CAMK2G Q13555 human ITPKB 3707 P27987 ITPKB human S174 3189511 PRLGRARsPsPCPFR X X +CAMK2G CAMK2G Q13555 human CAMK2G 818 Q13555 CAMK2G human S280 481026 CQRsTVAsMMHRQEt X +CAMK2G CAMK2G Q13555 human DAB2 1601 P98082 DAB2 human S723 18008467 KPAPRQVsLPVTkst X +CAMK2G CAMK2G Q13555 human LXR-beta 7376 P55055 NR1H2 human S426 18502600 RMLMKLVsLRTLsSV Hormone_recep X +CAMK2G CAMK2G Q13555 human occludin 100506658 Q16625 OCLN human S471 6094301 LDDyREEsEEyMAAA Occludin_ELL X +CAMK2G CAMK2G Q13555 human CACNA1H 8912 O95180 CACNA1H human S1198 22648004 tPLRRAEsLDPRPLR X +Gucy2e GUCY2D P52785 mouse GUCY2D 14919 P52785 Gucy2e mouse S538 11502404 RssLATRsASDIRSV X +Gucy2e GUCY2D P52785 mouse GUCY2D 14919 P52785 Gucy2e mouse S530 11502403 SRKVVQGsRssLATR X +Gucy2e GUCY2D P52785 mouse GUCY2D 14919 P52785 Gucy2e mouse S533 11502406 VVQGsRssLATRsAS X +Gucy2e GUCY2D P52785 mouse GUCY2D 14919 P52785 Gucy2e mouse S532 11502405 KVVQGsRssLATRsA X +PDK1 PDHK1 Q15118 human PDHA1 100294678 P29804 PDHA1 pig S231 448257 NRYGMGTsVERAAAS E1_dh X +PDK1 PDHK1 Q15118 human PDHA1 5160 P08559 PDHA1 human S300 448259 sMsDPGVsyRtREEI E1_dh X X +PDK1 PDHK1 Q15118 human PDHA1 18597 P35486 Pdha1 mouse S293 448258 TYRyHGHsMsDPGVs E1_dh X 31866; 37115; 48447 +PDK1 PDHK1 Q15118 human PDHA1 5160 P08559 PDHA1 human S293 448258 TYRyHGHsMsDPGVs E1_dh X X 31866; 37115; 48447 +PDK1 PDHK1 Q15118 human PDHA2 5161 P29803 PDHA2 human S298 458870 sMsDPGVsyRtREEI E1_dh X +PDK1 PDHK1 Q15118 human PDHA1 100294678 P29804 PDHA1 pig S299 448259 sMSDPGVsYRTREEI E1_dh X +PDK1 PDHK1 Q15118 human PDHA1 100294678 P29804 PDHA1 pig S292 448258 TYRYHGHsMSDPGVs E1_dh X 31866; 37115; 48447 +PDK1 PDHK1 Q15118 human PDHA1 5160 P08559 PDHA1 human S232 448257 NRyGMGtsVERAAAs E1_dh X X 15289 +PDK1 PDHK1 Q15118 human PDHA2 5161 P29803 PDHA2 human S291 458869 TYRyHGHsMsDPGVs E1_dh X 31866; 37115; 48447 +PDK1 PDHK1 Q15118 human PDHA2 5161 P29803 PDHA2 human S230 458871 NLYGMGTsTERAAAS E1_dh X +PDK1 PDHK1 Q15118 human PDHA1 18597 P35486 Pdha1 mouse S232 448257 NRyGMGtsVERAAAS E1_dh X +MAPK8 JNK1 P45983 human SIRT1 23411 Q96EB6 SIRT1 human S47 452899 DGPGLERsPGEPGGA X X 2314 +MAPK8 JNK1 P45983 human YAP1 iso3 10413 P46937-3 YAP1 human T154 3190681 VVSGPAAtPTAQHLR X +MAPK8 JNK1 P45983 human STMN2 84510 P21818 Stmn2 rat S62 450174 ELILKPPsPISEAPR Stathmin X +MAPK8 JNK1 P45983 human Tau iso8 4137 P10636-8 MAPT human T231 449079 KKVAVVRtPPKsPss X 20473; 71429 +MAPK8 JNK1 P45983 human JunB 3726 P17275 JUNB human T102 1814001 SNGVITTtPtPPGQy Jun X 8053 +MAPK8 JNK1 P45983 human SYT4 64440 P50232 Syt4 rat S135 4706863 ETEKEAVsPESLKSS X X +MAPK8 JNK1 P45983 human STMN1 29332 P13668 Stmn1 rat S38 448556 SVPEFPLsPPKKkDL Stathmin X 3426; 4191 +MAPK8 JNK1 P45983 human 4E-T 56478 Q9NRA8 EIF4ENIF1 human S513 3213594 NLEsHLMsPAEIPGQ EIF4E-T X X +MAPK8 JNK1 P45983 human EEF1A2 1917 Q05639 EEF1A2 human S358 27930803 GQISAGYsPVIDCHT GTP_EFTU_D3 X +MAPK8 JNK1 P45983 human ATF-2 1386 P15336 ATF2 human T69 448224 sVIVADQtPtPtRFL X X 9225; 94125; 40749; 61584; 44167 +MAPK8 JNK1 P45983 human APP iso4 351 P05067-4 APP human T668 448523 VEVDAAVtPEERHLs APP_amyloid X X +MAPK8 JNK1 P45983 human FOXO3A 2309 O43524 FOXO3 human S574 20799900 SAkHQQQsPVSQSMQ X +MAPK8 JNK1 P45983 human RARA 5914 P10276 RARA human S461 455330 RSSPATHsP______ X X +MAPK8 JNK1 P45983 human LMO7 iso3 361084 Q6JBI6 Lmo7 rat S1298 483780 SVKTsPGsPsPRSHs X +MAPK8 JNK1 P45983 human ATF-2 1386 P15336 ATF2 human T71 448225 IVADQtPtPtRFLkN X X 9225; 9221; 5112; 94125; 13850; 40749; 15411; 24329; 61584; 27934; 92109; 20534; 35858 +MAPK8 JNK1 P45983 human DRPLA 1822 P54259 ATN1 human S739 450317 EEyETPEsPVPPARs Atrophin-1 X +MAPK8 JNK1 P45983 human Nur77 3164 P22736 NR4A1 human S95 471072 TSSSSATsPASASFk X X +MAPK8 JNK1 P45983 human WDR62 284403 O43379 WDR62 human T1053 460021 PsssLPQtPEQEKFL X X +MAPK8 JNK1 P45983 human SP1 6667 P08047 SP1 human T278 1988302 SVSAATLtPSSQAVT X X +MAPK8 JNK1 P45983 human BIM 12125 O54918 Bcl2l11 mouse S114 449072 DKStQtPsPPCQAFN X +MAPK8 JNK1 P45983 human SMAD2 Q1W668 SMAD2 cow S245 448794 NQSMDTGsPAELsPT X +MAPK8 JNK1 P45983 human 14-3-3 sigma 2810 P31947 SFN human S186 456054 FHYEIANsPEEAISL 14-3-3 X X +MAPK8 JNK1 P45983 human DUSP8 18218 O09112 Dusp8 mouse S520 22598804 LDsPGtPsPDGPWCF X +MAPK8 JNK1 P45983 human JIP1 9479 Q9UQF2 MAPK8IP1 human T205 449954 PLKtGEQtPPHEHIC X +MAPK8 JNK1 P45983 human 4E-T 56478 Q9NRA8 EIF4ENIF1 human S301 14572931 DAVLPEQsPGDFDFN EIF4E-T X X +MAPK8 JNK1 P45983 human RBM17 84991 Q96I25 RBM17 human S222 3209223 EEQDRPRsPtGPsNs X +MAPK8 JNK1 P45983 human JIP3 30957 Q9ESN9 Mapk8ip3 mouse T287 458343 SVPSAAVtPLNESLQ X X +MAPK8 JNK1 P45983 human LAT iso2 27040 O43561-2 LAT human T155 451994 PSAPALStPGIRDSA LAT X X +MAPK8 JNK1 P45983 human CTNNB1 12387 Q02248 Ctnnb1 mouse S191 467710 SRHAIMRsPQMVSAI X +MAPK8 JNK1 P45983 human STAT6 6778 P42226 STAT6 human S707 17772900 IPPYQGLsPEESVNV STAT6_C X X +MAPK8 JNK1 P45983 human CTBP1 1487 Q13363 CTBP1 human S422 455350 AHPPHAPsPGQTVkP X X +MAPK8 JNK1 P45983 human NRL 18185 P54846 Nrl mouse S50 478419 PYSSVPPsPTFSEPG X +MAPK8 JNK1 P45983 human NFAT3 4776 Q14934 NFATC4 human S217 953803 GLGsPLPsPRAsPRP X +MAPK8 JNK1 P45983 human JunD 3727 P17535 JUND human S100 456168 LGLLkLAsPELERLI Jun X 9164 +MAPK8 JNK1 P45983 human DUSP8 18218 O09112 Dusp8 mouse S515 22598803 GWVPPLDsPGtPsPD X +MAPK8 JNK1 P45983 human NRF2 4780 Q16236 NFE2L2 human S408 10292700 GDMVQPLsPSQGQST X +MAPK8 JNK1 P45983 human GR 24413 P06536 Nr3c1 rat S246 451796 LIDENLLsPLAGEDD GCR X X 97285 +MAPK8 JNK1 P45983 human GAP43 14432 P06837 Gap43 mouse T172 449106 VtDAAAttPAAEDAA Neuromodulin X +MAPK8 JNK1 P45983 human 4E-T 56478 Q9NRA8 EIF4ENIF1 human S693 3213600 ASITSMLsPSFTPTS EIF4E-T X X +MAPK8 JNK1 P45983 human LIMD1 8994 Q9UGP4 LIMD1 human S277 451975 RVsPGLPsPNLENGA X X +MAPK8 JNK1 P45983 human LIMD1 8994 Q9UGP4 LIMD1 human S272 451974 TASsQRVsPGLPsPN X X +MAPK8 JNK1 P45983 human CTNNB1 1499 P35222 CTNNB1 human S37 447582 yLDsGIHsGATtTAP X X 9561; 2009; 4270; 13537; 41334; 60180 +MAPK8 JNK1 P45983 human Bcl-xL 598 Q07817 BCL2L1 human T115 448162 LTSQLHItPGTAYQS Bcl-2 X +MAPK8 JNK1 P45983 human LMO7 iso3 361084 Q6JBI6 Lmo7 rat S1300 449450 KTsPGsPsPRSHsPS X +MAPK8 JNK1 P45983 human GRB7 2886 Q14451 GRB7 human S194 58912301 KyELFKssPHSLFPE X +MAPK8 JNK1 P45983 human GLE1 2733 Q53GS7 GLE1 human S99 18010022 ssAFsPAsPAtPNGT X +MAPK8 JNK1 P45983 human CDT1 81620 Q9H211 CDT1 human S391 20804632 LRSAAPssPGsPrPA X +MAPK8 JNK1 P45983 human ATF-2 1386 P15336 ATF2 human S90 467297 GLFNELAsPFENEFk X X +MAPK8 JNK1 P45983 human MCL1 4170 Q07820 MCL1 human S64 479431 IGGSAGAsPPStLtP X 13297 +MAPK8 JNK1 P45983 human CDC25C 995 P30307 CDC25C human S168 449022 SEMKyLGsPIttVPK X +MAPK8 JNK1 P45983 human Raptor 57521 Q8N122 RPTOR human S696 11315003 EKNyALPsPAttEGG X X +MAPK8 JNK1 P45983 human Tau iso8 4137 P10636-8 MAPT human S396 449081 GAEIVyKsPVVsGDt X 9632 +MAPK8 JNK1 P45983 human YAP1 iso3 10413 P46937-3 YAP1 human S317 471290 GTQNPVSsPGMSQEL X +MAPK8 JNK1 P45983 human NEIL1 79661 Q96FI4 NEIL1 human S207 36704364 ALQQHRPsPELTLSQ X +MAPK8 JNK1 P45983 human MLP 17357 P28667 Marcksl1 mouse T183 454301 PQAAEPstPsGPEsG MARCKS X +MAPK8 JNK1 P45983 human PPAR-gamma 5468 P37231 PPARG human S112 448062 AIkVEPAsPPYYSEK X +MAPK8 JNK1 P45983 human CDT1 81620 Q9H211 CDT1 human T402 20804634 PrPALPAtPPAtPPA X +MAPK8 JNK1 P45983 human BID 637 P55957 BID human T59 448406 EGyDELQtDGNRsSH BID X X +MAPK8 JNK1 P45983 human SRC-3 8202 Q9Y6Q9 NCOA3 human S860 454106 NRAVsLDsPVsVGss X +MAPK8 JNK1 P45983 human 4E-T 56478 Q9NRA8 EIF4ENIF1 human S752 26392102 PsADRDssPttNSkL X X +MAPK8 JNK1 P45983 human K8 3856 P05787 KRT8 human S74 448539 tVNQsLLsPLVLEVD Keratin_2_head X +MAPK8 JNK1 P45983 human BIM iso2 10018 O43521-2 BCL2L11 human S58 449072 DKSTQtPsPPCQAFN X X +MAPK8 JNK1 P45983 human BIM 64547 O88498 Bcl2l11 rat S55 454235 GDRCPHGsPQGPLAP X 4550 +MAPK8 JNK1 P45983 human DUSP8 18218 O09112 Dusp8 mouse T518 22598802 PPLDsPGtPsPDGPW X +MAPK8 JNK1 P45983 human APP 54226 P08592 App rat T743 448523 VEVDAAVtPEERHLS APP_amyloid X X 3823; 6986 +MAPK8 JNK1 P45983 human Jun 3725 P05412 JUN human T91 450448 SNGHItTtPtPtQFL Jun X X 2303 +MAPK8 JNK1 P45983 human PKM iso2 5315 P14618-2 PKM human T365 31886917 CIMLSGEtAKGDyPL PK X +MAPK8 JNK1 P45983 human LIMD1 8994 Q9UGP4 LIMD1 human S421 3214989 LGSVLLDsPssPRVr X X +MAPK8 JNK1 P45983 human PIN1 5300 Q13526 PIN1 human S115 1873647702 sQFSDCssAkARGDL Rotamase X X +MAPK8 JNK1 P45983 human STMN2 11075 Q93045 STMN2 human S73 450173 EAPRTLAsPKKkDLs Stathmin X +MAPK8 JNK1 P45983 human NLRP3 114548 Q96P20 NLRP3 human S198 230295300 GKTKTCEsPVSPIKM FISNA X X +MAPK8 JNK1 P45983 human SRC-3 8202 Q9Y6Q9 NCOA3 human S543 454108 SLLSTLSsPGPKLDN NCOA_u2 X +MAPK8 JNK1 P45983 human JIP3 30957 Q9ESN9 Mapk8ip3 mouse T266 458341 GQSSAAAtPSTTGTK X X +MAPK8 JNK1 P45983 human AR 367 P10275 AR human S651 448414 GEASSTTsPTEETTQ X X +MAPK8 JNK1 P45983 human STAT3 6774 P40763 STAT3 human S727 448191 NtIDLPMsPrTLDSL X X 9134; 9136; 34911; 94994; 49081; 58978; 87544; 71958; 50804 +MAPK8 JNK1 P45983 human MCL1 4170 Q07820 MCL1 human S121 1172400 PAADAIMsPEEELDG X +MAPK8 JNK1 P45983 human CDT1 81620 Q9H211 CDT1 human S411 21440504 PAtPPAAsPsALkGV X +MAPK8 JNK1 P45983 human SP1 6667 P08047 SP1 human T739 448227 sEGSGtAtPSALITT X X +MAPK8 JNK1 P45983 human hnRNP K 3190 P61978 HNRNPK human S353 450147 DSAIDTWsPSEWQMA X +MAPK8 JNK1 P45983 human BIM iso2 10018 O43521-2 BCL2L11 human S44 449602 QTEPQDRsPAPMSCD X X +MAPK8 JNK1 P45983 human Bcl-xL 598 Q07817 BCL2L1 human S62 449099 PSWHLADsPAVNGAT X X +MAPK8 JNK1 P45983 human DIABLO 56616 Q9NR28 DIABLO human S6 31857552 __MAALKsWLsRsVt X X +MAPK8 JNK1 P45983 human ITCH 16396 Q8C863 Itch mouse S199 459622 kRANGNNsPSLSNGG X +MAPK8 JNK1 P45983 human OSBP2 23762 Q969R2 OSBP2 human S762 11171320 ECSKVMHssPssPsS Oxysterol_BP X +MAPK8 JNK1 P45983 human MAFB 16658 P54841 Mafb mouse T62 11555107 VSSTPLstPCssVPs X X +MAPK8 JNK1 P45983 human NRF2 4780 Q16236 NFE2L2 human S577 10292702 DEDGkPysPSEYSLQ X +MAPK8 JNK1 P45983 human eNOS 4846 P29474 NOS3 human S114 448638 RKLQGRPsPGPPAPE X X 9575 +MAPK8 JNK1 P45983 human SRC-3 8202 Q9Y6Q9 NCOA3 human T24 454110 KRKLPCDtPGQGLtC X 2979 +MAPK8 JNK1 P45983 human p21Cip1 1026 P38936 CDKN1A human S98 478193 GGRRPGTsPALLQGT X +MAPK8 JNK1 P45983 human CDC25B iso2 994 P30305-2 CDC25B human S103 9819903 GLCMDsPsPMDPHMA M-inducer_phosp X X +MAPK8 JNK1 P45983 human GLI2 2736 P10070 GLI2 human T1546 1874115100 QNSSRLTtPRNSLTL X X +MAPK8 JNK1 P45983 human STMN3 50861 Q9NZ72 STMN3 human S60 4698871 sFEVILksPSDLsPE Stathmin X +MAPK8 JNK1 P45983 human NF-E2 4778 Q16621 NFE2 human S346 18755000 DESGNSYsPEEYALQ X X +MAPK8 JNK1 P45983 human SIRT1 23411 Q96EB6 SIRT1 human S27 452898 ADREAAssPAGEPLR X X 2327 +MAPK8 JNK1 P45983 human OSBP2 23762 Q969R2 OSBP2 human S766 15721694 VMHssPssPsSDGKQ Oxysterol_BP X +MAPK8 JNK1 P45983 human BNIP3 84480 Q9ET45 Bnip3 rat T66 4698307 DsPPRSQtPQDTNRA BNIP3 X X +MAPK8 JNK1 P45983 human FOXO4 4303 P98177 FOXO4 human T451 448518 PIPKALGtPVLtPPt X X +MAPK8 JNK1 P45983 human GLE1 2733 Q53GS7 GLE1 human T102 472369 FsPAsPAtPNGTKGk X +MAPK8 JNK1 P45983 human JIP3 30957 Q9ESN9 Mapk8ip3 mouse T276 458342 TTGTKSNtPtSSVPS X X +MAPK8 JNK1 P45983 human ATF-2 11909 P16951 Atf2 mouse T51 448224 sVIVADQtPtPtRFL X 9225; 94125; 40749; 61584; 44167 +MAPK8 JNK1 P45983 human SREBP-1 6720 P36956 SREBF1 human S117 469986 YPSMPAFsPGPGIkE X X +MAPK8 JNK1 P45983 human GR 2908 P04150 NR3C1 human S226 451796 IDENCLLsPLAGEDD GCR X X 97285 +MAPK8 JNK1 P45983 human p53 7157 P04637 TP53 human T81 447540 APAPAAPtPAAPAPA X X 2676 +MAPK8 JNK1 P45983 human Bcl-2 596 P10415 BCL2 human S87 448396 AAAGPALsPVPPVVH X X +MAPK8 JNK1 P45983 human RBM17 84991 Q96I25 RBM17 human T71 470694 DDrQIVDtPPHVAAG X +MAPK8 JNK1 P45983 human SYT4 6860 Q9H2B2 SYT4 human S135 4706863 EGEKESVsPESLKSS X X +MAPK8 JNK1 P45983 human BIM 12125 O54918 Bcl2l11 mouse S65 449330 GPLAPPAsPGPFATR X 4581; 4585 +MAPK8 JNK1 P45983 human SREBP-1 iso3 6720 P36956-3 SREBF1 human T81 36533415 SPPQPAPtPLKMYPS X +MAPK8 JNK1 P45983 human SMAD2 Q1W668 SMAD2 cow S255 448796 ELsPTTLsPVNHSLD X +MAPK8 JNK1 P45983 human CDT1 81620 Q9H211 CDT1 human T29 455584 PPkLACRtPsPARPA X +MAPK8 JNK1 P45983 human Tau iso8 4137 P10636-8 MAPT human S202 447928 sGyssPGsPGtPGsR X X 39357; 30505 +MAPK8 JNK1 P45983 human Myc 4609 P01106 MYC human S86 449991 sRRsGLCsPSyVAVt Myc_N X X +MAPK8 JNK1 P45983 human MLP 17357 P28667 Marcksl1 mouse S120 454291 GGDssAssPtEEEQE MARCKS X +MAPK8 JNK1 P45983 human BIM iso2 10018 O43521-2 BCL2L11 human T56 449071 SCDKSTQtPsPPCQA X X +MAPK8 JNK1 P45983 human PSD-95 29495 P31016 Dlg4 rat S295 456936 PTsPRRYsPVAKDLL PDZ_assoc X 45737 +MAPK8 JNK1 P45983 human p21Cip1 1026 P38936 CDKN1A human S130 455618 sGEQAEGsPGGPGDs X X +MAPK8 JNK1 P45983 human SARM1 23098 Q6SZW1 SARM1 human S548 4739912 AAREMLHsPLPCTGG X X +MAPK8 JNK1 P45983 human RXRA 6256 P19793 RXRA human S260 450891 NMGLNPssPNDPVtN Hormone_recep X +MAPK8 JNK1 P45983 human p63 8626 Q9H3D4 TP63 human S51 28802100 TQtNEFLsPEVFQHI X +MAPK8 JNK1 P45983 human Doublecortin 13193 O88809 Dcx mouse S332 451363 StPKsKQsPIStPts X +MAPK8 JNK1 P45983 human EEF1A2 1917 Q05639 EEF1A2 human S205 27930804 GDNMLEPsPNMPWFK GTP_EFTU X +MAPK8 JNK1 P45983 human PXN 5829 P49023 PXN human S178 448603 PPLPGALsPLyGVPE Paxillin X X +MAPK8 JNK1 P45983 human Bcl-xL 598 Q07817 BCL2L1 human T47 448163 GTESEMEtPsAINGN X +MAPK8 JNK1 P45983 human BAD 12015 Q61337 Bad mouse T201 450485 NLGKGGStPSQ____ Bcl-2_BAD X X +MAPK8 JNK1 P45983 human NFAT1 18019 Q60591 Nfatc2 mouse S170 449624 YREPLCLsPAssGss X +MAPK8 JNK1 P45983 human AML3 860 Q13950 RUNX2 human S118 460037 AELVRTDsPNFLCSV Runt X X +MAPK8 JNK1 P45983 human NFAT1 18019 Q60591 Nfatc2 mouse S223 447847 PRtsPIMsPRTsLAE X +MAPK8 JNK1 P45983 human LMO7 iso3 361084 Q6JBI6 Lmo7 rat S1295 50307600 LAGSVKTsPGsPsPR X +MAPK8 JNK1 P45983 human HuR 1994 Q15717 ELAVL1 human S221 478357 QAQrFrFsPMGVDHM X +MAPK8 JNK1 P45983 human ARHGAP8 23779 P85298 ARHGAP8 human S455 3635677 tKPtLPPsPLMAARR X X +MAPK8 JNK1 P45983 human BNIP3 84480 Q9ET45 Bnip3 rat S60 17548869 SKSSHCDsPPRSQtP BNIP3 X X +MAPK8 JNK1 P45983 human BIM 64547 O88498 Bcl2l11 rat S65 449330 GPLAPPAsPGPFATR X X 4581; 4585 +MAPK8 JNK1 P45983 human Bcl-2 596 P10415 BCL2 human S70 448395 RDPVARtsPLQtPAA X X 2834; 2827 +MAPK8 JNK1 P45983 human SRC-3 8202 Q9Y6Q9 NCOA3 human S867 454107 sPVsVGssPPVKNIS X +MAPK8 JNK1 P45983 human TWIST1 7291 Q15672 TWIST1 human S68 18905000 GGGDEPGsPAQGkRG X X +MAPK8 JNK1 P45983 human PPM1J 71887 Q149T7 Ppm1j mouse S92 2846507 HAGRAVQsPPDTGRR X X +MAPK8 JNK1 P45983 human NFAT3 4776 Q14934 NFATC4 human S213 953804 ASRFGLGsPLPsPRA X +MAPK8 JNK1 P45983 human DIABLO 56616 Q9NR28 DIABLO human S9 31857555 AALKsWLsRsVtSFF Smac_DIABLO X X +MAPK8 JNK1 P45983 human ELF4 2000 Q99607 ELF4 human S641 463812 SGSLLTRsPtPAPFs X X +MAPK8 JNK1 P45983 human Jun 3725 P05412 JUN human S73 447943 VGLLkLAsPELERLI Jun X X 9164; 3270; 8752; 12714; 77955 +MAPK8 JNK1 P45983 human SREBP-1 iso3 6720 P36956-3 SREBF1 human S93 469986 YPSMPAFsPGPGIKE X +MAPK8 JNK1 P45983 human CDC25B iso2 994 P30305-2 CDC25B human S101 9819902 DAGLCMDsPsPMDPH M-inducer_phosp X X +MAPK8 JNK1 P45983 human Jun 16476 P05627 Jun mouse S63 447686 kNsDLLtsPDVGLLK Jun X X 5464; 9261; 2361; 97721; 91952 +MAPK8 JNK1 P45983 human MST1 6789 Q13043 STK4 human S82 12057400 SIMQQCDsPHVVKYY Pkinase X X +MAPK8 JNK1 P45983 human STMN1 16765 P54227 Stmn1 mouse S38 448556 sVPdFPLsPPKKKDL Stathmin X X 3426; 4191 +MAPK8 JNK1 P45983 human STMN2 84510 P21818 Stmn2 rat S73 450173 EAPRTLAsPKKkDLs Stathmin X +MAPK8 JNK1 P45983 human DGCR8 54487 Q8WYQ5 DGCR8 human S153 34490414 AECGLLLsPVSGDVH X X +MAPK8 JNK1 P45983 human ABRA 286965 Q8K4K7 Abra rat T62 1255792402 ATQDLPHtPKEPGPR X X +MAPK8 JNK1 P45983 human p53 7157 P04637 TP53 human S20 447529 PLsQEtFsDLWkLLP P53_TAD X X 9287 +MAPK8 JNK1 P45983 human 4E-T 56478 Q9NRA8 EIF4ENIF1 human S587 454357 yLrPrIPsPIGFtPG EIF4E-T X X +MAPK8 JNK1 P45983 human Bcl-2 12043 P10417 Bcl2 mouse S70 448395 RDMAARtsPLRPLVA X X +MAPK8 JNK1 P45983 human NFAT1 18019 Q60591 Nfatc2 mouse T116 455763 PsPRIEItPSHELMQ X X +MAPK8 JNK1 P45983 human SCYE1 9255 Q12904 AIMP1 human S140 12440055 KKEKkQQsIAGsADS X X +MAPK8 JNK1 P45983 human Raptor 57521 Q8N122 RPTOR human S863 453732 LtQsAPAsPtNkGVH X X +MAPK8 JNK1 P45983 human NRF2 4780 Q16236 NFE2L2 human S215 10292704 VETTMVPsPEAKLTE X +MAPK8 JNK1 P45983 human Tau iso8 4137 P10636-8 MAPT human T181 447932 ktPPAPktPPssGEP X 12885; 66224; 62672 +MAPK8 JNK1 P45983 human HES1 29577 Q04666 Hes1 rat S263 23298200 SVGPNAVsPSSGSSL X X +MAPK8 JNK1 P45983 human LMO7 iso3 361084 Q6JBI6 Lmo7 rat S1305 3207705 sPsPRSHsPSMSQSG X +MAPK8 JNK1 P45983 human MARCKS 4082 P29966 MARCKS human S46 454165 VKVNGDAsPAAAEsG MARCKS X +MAPK8 JNK1 P45983 human Jun 3725 P05412 JUN human S63 447686 kNsDLLtsPDVGLLk Jun X X 5464; 9261; 2361; 97721; 91952 +MAPK8 JNK1 P45983 human ATF-2 11909 P16951 Atf2 mouse T53 448225 IVADQtPtPtRFLKN X 9225; 9221; 5112; 94125; 13850; 40749; 15411; 24329; 61584; 27934; 92109; 20534; 35858 +MAPK8 JNK1 P45983 human SIRT6 51548 Q8N6T7 SIRT6 human S10 23144710 VNYAAGLsPYADKGk X X +MAPK8 JNK1 P45983 human MCL1 4170 Q07820 MCL1 human T163 455375 tDGsLPstPPPAEEE X 4579; 14765 +MAPK8 JNK1 P45983 human Bcl-2 596 P10415 BCL2 human T69 448398 SRDPVARtsPLQtPA X +MAPK8 JNK1 P45983 human CDT1 81620 Q9H211 CDT1 human S491 21440505 GSCCTIMsPGEMEKH CDT1_C X +MAPK8 JNK1 P45983 human SHC1 20416 P98083 Shc1 mouse S36 448508 TPPEELPsPSASSLG X X +MAPK8 JNK1 P45983 human OSBP2 23762 Q969R2 OSBP2 human S768 15721697 HssPssPsSDGKQKT Oxysterol_BP X +MAPK8 JNK1 P45983 human BMF 90427 Q96LC9 BMF human S74 11267001 DKATQTLsPAsPSQG BMF X +MAPK8 JNK1 P45983 human SND1 27044 Q7KZF4 SND1 human T103 18015998 CFtIENktPQGrEyG SNase X X +MAPK8 JNK1 P45983 human GAP43 14432 P06837 Gap43 mouse S96 449105 tDAAPAtsPkAEEPs Neuromodulin X +MAPK8 JNK1 P45983 human Myc 4609 P01106 MYC human S77 448586 LLPtPPLsPsRRsGL Myc_N X X 13748 +MAPK8 JNK1 P45983 human NEIL1 79661 Q96FI4 NEIL1 human S61 57829900 KELRLILsPLPGAQP Fapy_DNA_glyco X +MAPK8 JNK1 P45983 human CDK4 1019 P11802 CDK4 human T172 448476 YSYQMALtPVVVTLW Pkinase X +MAPK8 JNK1 P45983 human STMN1 16765 P54227 Stmn1 mouse S25 448555 QAFELILsPRskEsV Stathmin X X +MAPK8 JNK1 P45983 human CTNNB1 1499 P35222 CTNNB1 human S33 447487 QQQsyLDsGIHsGAT X X 9561; 2009; 4270; 13537; 41334; 60180 +MAPK8 JNK1 P45983 human Raptor 57521 Q8N122 RPTOR human T706 11315002 ttEGGsLtPVRDsPC X X +MAPK8 JNK1 P45983 human BIM 12125 O54918 Bcl2l11 mouse S100 449602 FSFDTDRsPAPMsCD X +MAPK8 JNK1 P45983 human GNMT 27232 Q14749 GNMT human S10 460706 DSVYRtRsLGVAAEG X +MAPK8 JNK1 P45983 human PPM1J 71887 Q149T7 Ppm1j mouse T202 2846508 PPLCLPStPGtPGAP X X +MAPK8 JNK1 P45983 human NFAT2 4772 O95644 NFATC1 human S172 465577 YRDPsCLsPASSLSS X +MAPK8 JNK1 P45983 human 4E-T 56478 Q9NRA8 EIF4ENIF1 human S374 7322864 GLEQAILsPGQNsGN EIF4E-T X X +MAPK8 JNK1 P45983 human SIRT1 23411 Q96EB6 SIRT1 human T530 6006905 YLSELPPtPLHVsED X X +MAPK8 JNK1 P45983 human JunB 3726 P17275 JUNB human T104 1814000 GVITTtPtPPGQyFy Jun X 8053 +MAPK8 JNK1 P45983 human Oct4 18999 P20263 Pou5f1 mouse S347 25236701 VPVtALGsPMHSN__ X +MAPK8 JNK1 P45983 human CTNNB1 12387 Q02248 Ctnnb1 mouse S605 3545003 LFVQLLYsPIENIQR Arm X +MAPK8 JNK1 P45983 human MLP 17357 P28667 Marcksl1 mouse T148 454299 QEGKAAAtPEsQEPQ MARCKS X +MAPK8 JNK1 P45983 human RARA 5914 P10276 RARA human T181 455328 CSESYTLtPEVGELI X X +MAPK8 JNK1 P45983 human MAP2 25595 P15146 Map2 rat T1622 450181 YSSRtPGtPGtPSyP X 4544 +MAPK8 JNK1 P45983 human MAP2 25595 P15146 Map2 rat T1619 4704347 PPsYSSRtPGtPGtP X +MAPK8 JNK1 P45983 human OSBP2 23762 Q969R2 OSBP2 human S763 31727226 CSKVMHssPssPsSD Oxysterol_BP X +MAPK8 JNK1 P45983 human IRS1 3667 P35568 IRS1 human S312 447558 tEsItAtsPAsMVGG X 2381 +MAPK8 JNK1 P45983 human TAB1 10454 Q15750 TAB1 human S438 456224 tPTLTNQsPTLtLQS X X +MAPK8 JNK1 P45983 human JIP1 9479 Q9UQF2 MAPK8IP1 human T103 449924 LIDAtGDtPGAEDDE X X +MAPK8 JNK1 P45983 human CTNNB1 1499 P35222 CTNNB1 human T41 447583 GIHsGATtTAPsLsG X X 9561; 9565; 4270; 13537; 41334; 60180 +MAPK8 JNK1 P45983 human LIMD1 8994 Q9UGP4 LIMD1 human S424 3214995 VLLDsPssPRVrLPC X X +MAPK8 JNK1 P45983 human mGluR5 24418 P31424 Grm5 rat T1087 1876620108 ATPGPPGtPICSSYL X X +MAPK8 JNK1 P45983 human IP3R1 16438 P11881 Itpr1 mouse S1755 450682 RPSGRREsLtsFGNG X 3760; 8548 +MAPK8 JNK1 P45983 human GLE1 2733 Q53GS7 GLE1 human S93 31084897 PKsPDAssAFsPAsP X +MAPK8 JNK1 P45983 human 14-3-3 zeta 7534 P63104 YWHAZ human S184 449855 FyYEILNsPEKACSL 14-3-3 X X +MAPK8 JNK1 P45983 human FOXO4 4303 P98177 FOXO4 human T455 448570 ALGtPVLtPPtEAAS X X +MAPK8 JNK1 P45983 human NEIL1 79661 Q96FI4 NEIL1 human S306 34504097 KSKATQLsPEDRVED X +MAPK8 JNK1 P45983 human 14-3-3 beta 7529 P31946 YWHAB human S186 449845 FyYEILNsPEKACSL 14-3-3 X +MAPK8 JNK1 P45983 human FOXO4 4303 P98177 FOXO4 human T227 15798100 PAPPEGAtPTsPVGH X X +MAPK8 JNK1 P45983 human FOXO4 4303 P98177 FOXO4 human S230 471960 PEGAtPTsPVGHFAK X +MAPK8 JNK1 P45983 human GLE1 2733 Q53GS7 GLE1 human S92 50831365 VPKsPDAssAFsPAs X +MAPK8 JNK1 P45983 human RARA 5914 P10276 RARA human S445 455329 APPPGSCsPSLSPSS X X +MAPK8 JNK1 P45983 human PPM1J 71887 Q149T7 Ppm1j mouse T205 2846509 CLPStPGtPGAPSPS X X +MAPK8 JNK1 P45983 human NFAT1 18019 Q60591 Nfatc2 mouse S110 1861201 PAGAsGPsPRIEItP X +MAPK8 JNK1 P45983 human NFAT1 18019 Q60591 Nfatc2 mouse S219 447846 AHYsPRtsPIMsPRT X +MAPK8 JNK1 P45983 human MAP2 25595 P15146 Map2 rat T1625 450182 RtPGtPGtPSyPRTP X 4544 +MAPK8 JNK1 P45983 human CDT1 81620 Q9H211 CDT1 human T406 21440503 LPAtPPAtPPAAsPs X +MAPK8 JNK1 P45983 human BIM 12125 O54918 Bcl2l11 mouse T112 449071 sCDKStQtPsPPCQA X +MAPK8 JNK1 P45983 human LMO7 iso3 361084 Q6JBI6 Lmo7 rat S727 4687599 SLREVSRsPDQFSDM X +MAPK8 JNK1 P45983 human hnRNP K 3190 P61978 HNRNPK human S216 450148 ILDLIsEsPIkGRAQ X +MAPK8 JNK1 P45983 human GLE1 2733 Q53GS7 GLE1 human S88 12667856 QPSFVPKsPDAssAF X +MAPK8 JNK1 P45983 human IRF3 3661 Q14653 IRF3 human S173 6370303 PCPQPLRsPsLDNPt X X +MAPK8 JNK1 P45983 human K8 3856 P05787 KRT8 human S432 448540 sAyGGLtsPGLsysL X +MAPK8 JNK1 P45983 human FOXO3A 56484 Q9WVH4 Foxo3 mouse S573 20799900 SAkHQQQsPASQSMQ X +MAPK8 JNK1 P45983 human p21Cip1 1026 P38936 CDKN1A human T57 451222 NFDFVtEtPLEGDFA CDI X +MAPK8 JNK1 P45983 human ITCH 16396 Q8C863 Itch mouse T222 459624 PSRPPPPtPRRPASV X +MAPK8 JNK1 P45983 human NFAT1 18019 Q60591 Nfatc2 mouse T332 451863 WKtsPDPtPVSTAPS X +MAPK8 JNK1 P45983 human ITCH 16396 Q8C863 Itch mouse S232 459623 RPASVNGsPSTNSDS X +MAPK8 JNK1 P45983 human YAP1 iso3 10413 P46937-3 YAP1 human T362 23939103 SSySVPRtPDDFLNS X X +MAPK8 JNK1 P45983 human DCP1A 55802 Q9NPI6 DCP1A human S315 3213294 PtytIPLsPVLsPtL X X +MAPK8 JNK1 P45983 human SRC-3 8202 Q9Y6Q9 NCOA3 human S505 454109 SPVAGVHsPMAsSGN NCOA_u2 X +MAPK8 JNK1 P45983 human Jun 3725 P05412 JUN human T93 450449 GHItTtPtPtQFLCP Jun X X 2993 +MAPK8 JNK1 P45983 human APLP2 334 Q06481 APLP2 human T736 451599 VEVDPMLtPEERHLN APP_amyloid X X +MAPK8 JNK1 P45983 human STAT1 20846 P42225 Stat1 mouse S727 447753 tDNLLPMsPEEFDEM STAT1_TAZ2bind X 9177; 8826; 62390 +MAPK8 JNK1 P45983 human IRS2 384783 P81122 Irs2 mouse S488 1308920 GSAsASGsPSDPGFM X +MAPK8 JNK1 P45983 human NF-E2 4778 Q16621 NFE2 human S157 11489902 LNYSDAEsLELEGTE X X +MARK3 MARK3 P27448 human MEF2C 4208 Q06413 MEF2C human S222 474086 GYGNPRNsPGLLVsP X +MARK3 MARK3 P27448 human PPP1R2 5504 P41236 PPP1R2 human S72 3190237 LMKIDEPstPyHSMM IPP-2 X +MARK3 MARK3 P27448 human CDC25C 995 P30307 CDC25C human S216 448418 sGLyRsPsMPENLNR M-inducer_phosp X 9528; 4901; 30790 +MARK3 MARK3 P27448 human TNK1 8711 Q13470 TNK1 human S502 483166 RMKGIsRsLEsVLsL X +MARK3 MARK3 P27448 human FEZ1 9638 Q99689 FEZ1 human S58 454522 SEIISFKsMEDLVNE FEZ X X +MARK3 MARK3 P27448 human ARHGEF2 9181 Q92974 ARHGEF2 human S151 1211018 LsLAksVsttNIAGH X X +MARK3 MARK3 P27448 human TORC2 74343 Q3U182 Crtc2 mouse S275 3174300 PAMNTGGsLPDLTNL TORC_M X +Tek TIE2 Q02858 mouse TIE2 21687 Q02858 Tek mouse Y1100 450256 MLEERKTyVNTTLyE X X +AKT2 Akt2 P31751 human SFRS5 29667 Q09167 Srsf5 rat S86 3685800 GRGRGRYsDRFSSRR X +AKT2 Akt2 P31751 human ATP7A 538 Q04656 ATP7A human S1424 50479822 SYELPARsQIGQKsP X X +AKT2 Akt2 P31751 human plakophilin 1 5317 Q13835 PKP1 human S63 18261122 ssQsstLsHsNRGsM X X +AKT2 Akt2 P31751 human GAB2 14389 Q9Z1S8 Gab2 mouse T388 448383 ATIPRRNtLPAMDNS X +AKT2 Akt2 P31751 human IRF3 3661 Q14653 IRF3 human T180 28095000 sPsLDNPtPFPNLGP X +AKT2 Akt2 P31751 human CD34 12490 Q64314 Cd34 mouse S343 4733136 yssGPGAsPETQGkA CD34_antigen X +AKT2 Akt2 P31751 human QIK 235344 Q8CFH6 Sik2 mouse S358 487501 DGRQRRPstIAEQTV X +AKT2 Akt2 P31751 human EGFR 1956 P00533 EGFR human S229 18944906 rCrGKSPsDCCHNQC Furin-like X +AKT2 Akt2 P31751 human plakophilin 1 5317 Q13835 PKP1 human T179 27717307 LGsKGQKttQNRysF X X +AKT2 Akt2 P31751 human Ezrin 7430 P15311 EZR human T567 448104 QGRDkyKtLRQIRQG ERM_C X X 3141; 3726; 32600 +AKT2 Akt2 P31751 human CBY1 25776 Q9Y3M2 CBY1 human S20 2850009 TPPRKsAsLSNLHsL Chibby X +AKT2 Akt2 P31751 human CLK2 12748 O35491 Clk2 mouse T343 26375903 HHSTIVstRHYRAPE Pkinase X +AKT2 Akt2 P31751 human HSF1 3297 Q00613 HSF1 human S230 448072 PkYSRQFsLEHVHGS X X +AKT2 Akt2 P31751 human BMI1 648 P35226 BMI1 human S316 6150348 ANRPRKssVNGSSAT X X +AKT2 Akt2 P31751 human ADAR 103 P55265 ADAR human T1033 1868546602 RLGERLRtMSCSDKI A_deamin X +AKT2 Akt2 P31751 human plakophilin 1 5317 Q13835 PKP1 human S191 15405309 ysFystCsGQKAIKK X X +AKT2 Akt2 P31751 human FLNC 2318 Q14315 FLNC human S2233 467899 LGRERLGsFGsItRQ Filamin X +AKT2 Akt2 P31751 human plakophilin 1 5317 Q13835 PKP1 human T180 27717309 GsKGQKttQNRysFy X X +AKT2 Akt2 P31751 human IRS2 8660 Q9Y4H2 IRS2 human S365 483509 sCRVRtAsEGDGGAA X +AKT2 Akt2 P31751 human H3 8350 P68431 H3C1 human S10 455676 tkQtArkstGGkAPr Histone X 9701; 9711; 9606; 3465; 3642; 3377; 3475; 3458; 5764; 47398; 8481; 8552; 53348; 29237; 66065; 43185; 64522; 52725 +AKT2 Akt2 P31751 human WIPF1 7456 O43516 WIPF1 human T398 14582886 TSRALPAtPQLPSrS X X +AKT2 Akt2 P31751 human plakophilin 1 5317 Q13835 PKP1 human S127 7102607 ysQMENWsRHYPRGS X X +AKT2 Akt2 P31751 human EDC3 80153 Q96F86 EDC3 human S161 1211074 sFRRRHNsWssssRH Edc3_linker X +AKT2 Akt2 P31751 human ATP7A 538 Q04656 ATP7A human S1466 4733428 ysRAsINsLLsDkRs X X +AKT2 Akt2 P31751 human plakophilin 1 5317 Q13835 PKP1 human S118 4712605 EPDNRRFssysQMEN X X +AKT2 Akt2 P31751 human BAP37 11331 Q99623 PHB2 human S91 22342307 RARPRkIssPTGSkD Band_7 X +AKT2 Akt2 P31751 human IKKA 1147 O15111 CHUK human T23 447780 EMRERLGtGGFGNVC Pkinase X X +AKT2 Akt2 P31751 human BAP37 11331 Q99623 PHB2 human S176 31828200 TERAKDFsLILDDVA Band_7 X +AKT2 Akt2 P31751 human H3 8350 P68431 H3C1 human S28 455677 ATkAArksAPATGGV Histone X 9713 +AKT2 Akt2 P31751 human RED1 104 P78563 ADARB1 human T553 31884906 LQGERLLtMSCSDKI A_deamin X +AKT2 Akt2 P31751 human plakophilin 1 5317 Q13835 PKP1 human S65 465636 QsstLsHsNRGsMyD X X +AKT2 Akt2 P31751 human MYO5A 17918 Q99104 Myo5a mouse S1650 480053 GLRKRtssIADEGty X +AKT2 Akt2 P31751 human lamin A/C 4000 P02545 LMNA human S390 452605 EEErLRLsPsPtsQR X X +AKT2 Akt2 P31751 human ATP7A 538 Q04656 ATP7A human S1463 4733422 IVNysRAsINsLLsD X X +AKT2 Akt2 P31751 human plakophilin 1 5317 Q13835 PKP1 human T171 27717301 RGtLRKGtLGsKGQK X X +AKT2 Akt2 P31751 human CAD 69719 B2RQC6 Cad mouse S1406 451249 GAGGRRLssFVTKGY MGS X +AKT2 Akt2 P31751 human CAD 69719 B2RQC6 Cad mouse S1859 451247 PPRIHRAsDPGLPAE X 12662; 67235; 70307 +AKT2 Akt2 P31751 human plakophilin 1 5317 Q13835 PKP1 human T82 15405303 ADNyNyGttsRssYy X X +AKT2 Akt2 P31751 human IRF3 3661 Q14653 IRF3 human S175 14567912 PQPLRsPsLDNPtPF X +AKT2 Akt2 P31751 human PPIF 10105 P30405 PPIF human S31 40256000 LPAARACsKGsGDPS X X +AKT2 Akt2 P31751 human plakophilin 1 5317 Q13835 PKP1 human T61 27717305 sKssQsstLsHsNRG X X +AKT2 Akt2 P31751 human GAPDH 2597 P04406 GAPDH human T237 4658322 GMAFrVPtANVsVVD Gp_dh_C X +AKT2 Akt2 P31751 human PITX2 18741 P97474 Pitx2 mouse T90 25790902 KRQRRQRtHFTSQQL Homeodomain X +AKT2 Akt2 P31751 human plakophilin 1 5317 Q13835 PKP1 human S69 23132559 LsHsNRGsMyDGLAD X X +AKT2 Akt2 P31751 human plakophilin 1 5317 Q13835 PKP1 human S174 27717303 LRKGtLGsKGQKttQ X X +AKT2 Akt2 P31751 human lamin A/C 4000 P02545 LMNA human S404 478681 RsRGRAssHssQtQG X +AKT2 Akt2 P31751 human plakophilin 1 5317 Q13835 PKP1 human S54 27717310 MTVKRQKsKssQsst X X +AKT2 Akt2 P31751 human ASK1 4217 Q99683 MAP3K5 human S83 447735 ATRGRGssVGGGSrR X X 3761 +AKT2 Akt2 P31751 human HTRA2 27429 O43464 HTRA2 human S212 477180 RVRVRLLsGDTYEAV Trypsin_2; Peptidase_M50 X X +AKT2 Akt2 P31751 human hnRNP E1 23983 P60335 Pcbp1 mouse S43 13258708 VKRIREEsGARINIs KH_1 X +AKT2 Akt2 P31751 human LBR G1N806 LBR turkey S82 14575430 RSRsRsRsRsPGRPA X +AKT2 Akt2 P31751 human plakophilin 1 5317 Q13835 PKP1 human S185 15405312 KttQNRysFystCsG X X +AKT2 Akt2 P31751 human XIAP 331 P98170 XIAP human S87 450336 VGRHRKVsPNCRFIN BIR X X +AKT2 Akt2 P31751 human plakophilin 1 5317 Q13835 PKP1 human S57 27717308 KRQKsKssQsstLsH X X +AKT2 Akt2 P31751 human IRF3 3661 Q14653 IRF3 human S14 23116256 RILPWLVsQLDLGQL IRF X +AKT2 Akt2 P31751 human CYCS 54205 P99999 CYCS human Y47 3416311 ktGQAPGysytAANk Cytochrom_C X +AKT2 Akt2 P31751 human IRS2 8660 Q9Y4H2 IRS2 human S1149 453435 GGRRRHssEtFSsTt X 2385 +AKT2 Akt2 P31751 human RENT1 5976 Q92900 UPF1 human T151 50788283 FCNGRGNtSGSHIVN UPF1_Zn_bind X +AKT2 Akt2 P31751 human p300 328572 B2RWS6 Ep300 mouse S1733 1295500 PGDSRRLsIQRCIQS X +AKT2 Akt2 P31751 human GATA6 iso2 2627 Q92908-2 GATA6 human S290 18009944 KPQKRVPsSRRLGLS X X +AKT2 Akt2 P31751 human ER-alpha 2099 P03372 ESR1 human S167 448102 GGRERLAsTNDkGSM Oest_recep X 64508; 42101 +AKT2 Akt2 P31751 human plakophilin 1 5317 Q13835 PKP1 human T166 15405306 LyCDPRGtLRKGtLG X X +AKT2 Akt2 P31751 human plakophilin 1 5317 Q13835 PKP1 human T189 15413424 NRysFystCsGQKAI X X +AKT2 Akt2 P31751 human fascin 6624 Q16658 FSCN1 human T403 15720201 GCRkVTGtLDANRSS Fascin X X +AKT2 Akt2 P31751 human MgcRacGAP 29127 Q9H0H5 RACGAP1 human T249 478691 WTRSRRktGtLQPWN X +AKT2 Akt2 P31751 human IRS2 8660 Q9Y4H2 IRS2 human S306 3217341 EFRPRsksQssGssA X X +AKT2 Akt2 P31751 human LBR G1N806 LBR turkey S80 14575427 SRRSRsRsRsRsPGR X +AKT2 Akt2 P31751 human RSK2 6197 P51812 RPS6KA3 human T115 1880515604 KVRDRVRtKMERDIL X +AKT2 Akt2 P31751 human Merlin 4771 P35240 NF2 human S10 1720901 GAIASRMsFSsLkRK X +AKT2 Akt2 P31751 human plakophilin 1 5317 Q13835 PKP1 human S188 15413421 QNRysFystCsGQKA X X +AKT2 Akt2 P31751 human plakophilin 1 5317 Q13835 PKP1 human S84 27717311 NyNyGttsRssYySK X X +AKT2 Akt2 P31751 human plakophilin 1 5317 Q13835 PKP1 human S60 27717302 KsKssQsstLsHsNR X X +AKT2 Akt2 P31751 human plakophilin 1 5317 Q13835 PKP1 human S121 465635 NRRFssysQMENWsR X X +AKT2 Akt2 P31751 human KHSRP 8570 Q92945 KHSRP human S193 473552 GLPERsVsLtGAPEs KH_1 X +AKT2 Akt2 P31751 human PIP5K1C 23396 O60331 PIP5K1C human S555 1855423 RYRRRtQssGQDGRP X +AKT2 Akt2 P31751 human MAT1A 4143 Q00266 MAT1A human T202 1874404504 VIPVRIHtIVISVQH S-AdoMet_synt_M X +AKT2 Akt2 P31751 human TMOD3 50875 Q9JHJ0 Tmod3 mouse S71 456118 FDRERLLsYLEkQAL Tropomodulin X X +AKT2 Akt2 P31751 human HSF1 3297 Q00613 HSF1 human S326 455484 ssVDtLLsPTALIDs Vert_HS_TF X +AKT2 Akt2 P31751 human CTNNB1 1499 P35222 CTNNB1 human S552 472273 QDtQRRtsMGGtQQQ X X 9566; 5651 +AKT2 Akt2 P31751 human ANKRD2 26287 Q9GZV1 ANKRD2 human S99 480101 QERVRKTsLDLRREI X X +AKT2 Akt2 P31751 human IRS2 8660 Q9Y4H2 IRS2 human S577 483923 GLRKRtysLttPARQ X X +AKT2 Akt2 P31751 human IRF3 3661 Q14653 IRF3 human T207 1876336802 EEWEFEVtAFYRGRQ IRF-3 X +AKT2 Akt2 P31751 human HK2 15277 O08528 Hk2 mouse T473 28704601 QHRARQKtLESLKLS Hexokinase_1 X +AKT2 Akt2 P31751 human CDP138 9847 Q86YS7 C2CD5 human S197 21398500 EARQRLIsLMsGELQ X X +AKT2 Akt2 P31751 human SH3RF1 57630 Q7Z6J0 SH3RF1 human S304 482847 KNTKKRHsFtsLtMA X +AKT2 Akt2 P31751 human p300 328572 B2RWS6 Ep300 mouse S1833 447591 MLRRRMAsMQRTGVA X +AKT2 Akt2 P31751 human PDHK1 5163 Q15118 PDK1 human T346 13831355 APRPRVEtsRAVPLA HATPase_c X X +AKT2 Akt2 P31751 human plakophilin 1 5317 Q13835 PKP1 human S59 27717304 QKsKssQsstLsHsN X X +AKT2 Akt2 P31751 human H3 8350 P68431 H3C1 human T45 455679 PHryrPGtVALrEIR Histone X X +AKT2 Akt2 P31751 human plakophilin 1 5317 Q13835 PKP1 human S119 4712610 PDNRRFssysQMENW X X +AKT2 Akt2 P31751 human EPRS 2058 P07814 EPRS1 human S999 9720900 NQGGGLsssGAGEGQ X +AKT2 Akt2 P31751 human WIPF1 7456 O43516 WIPF1 human S154 23073655 PGrFPVPsPGHRSGP X +AKT2 Akt2 P31751 human plakophilin 1 5317 Q13835 PKP1 human S56 27717306 VKRQKsKssQsstLs X X +AKT2 Akt2 P31751 human MAT1A 4143 Q00266 MAT1A human S180 1874404502 LPWLRPDsKTQVTVQ S-AdoMet_synt_M X +AKT2 Akt2 P31751 human GAB2 14389 Q9Z1S8 Gab2 mouse S211 4825112 TENARSAsFSQGTRQ X +HIPK3 HIPK3 Q9H422 human DAXX 1616 Q9UER7 DAXX human S668 448623 KKICtLPsPPsPLAs X +PRKCB PKCB P05771 human ANXA1 301 P04083 ANXA1 human S28 452053 yVQtVksskGGPGsA X +PRKCB PKCB P05771 human CARD11 416476 Q5F3W0 RCJMB04_5k17 chicken S668 457639 LERPFRPsVTSVGRI X X 5189 +PRKCB PKCB P05771 human Tau iso8 4137 P10636-8 MAPT human S352 487459 DFKDrVQskIGsLDN Tubulin-binding X +PRKCB PKCB P05771 human ITGB2 3689 P05107 ITGB2 human S745 448532 FEkEKLksQWNNDNP Integrin_b_cyt X +PRKCB PKCB P05771 human PKCB iso2 5579 P05771-2 PRKCB human S660 1869073011 QsEFEGFsFVNsEFL Pkinase_C X 9371 +PRKCB PKCB P05771 human CACNA1C 100101555 P15381 CACB rabbit S1928 455278 ASLGRRAsFHLECLK CAC1F_C X X +PRKCB PKCB P05771 human SHP-2 5781 Q06124 PTPN11 human S591 469623 GLMQQQksFR_____ X +PRKCB PKCB P05771 human MYH9 4627 P35579 MYH9 human S1916 451181 AMNREVssLkNkLRr Myosin_tail_1 X +PRKCB PKCB P05771 human ANXA2 302 P07355 ANXA2 human S26 450879 tPPsAyGsVkAytNF X +PRKCB PKCB P05771 human CARD11 108723 Q8CIS0 Card11 mouse S564 457637 QPHRSRSsIMsItAE X +PRKCB PKCB P05771 human LIN28B 389421 Q6ZN17 LIN28B human S243 1870790709 EQSKkGPsVQKRKKT X +PRKCB PKCB P05771 human ORAI1 84876 Q96D31 ORAI1 human S27 469411 GGSTTsGsRRsRRRs X X +PRKCB PKCB P05771 human Kv3.4 3749 Q03721 KCNC4 human S9 451076 ISSVCVssYRGRKsG Potassium_chann X +PRKCB PKCB P05771 human ATP1A1 24211 P06685 Atp1a1 rat S16 449086 KyEPAAVsEHGDkks X 4020 +PRKCB PKCB P05771 human ITGB2 3689 P05107 ITGB2 human T758 448533 NPLFksAtttVMNPk Integrin_b_cyt X +PRKCB PKCB P05771 human PIK3CG 5294 P48736 PIK3CG human S582 28702402 LWHFRYEsLKHPKAY PI3Ka X X +PRKCB PKCB P05771 human Akt1 207 P31749 AKT1 human S473 447855 RPHFPQFsysAsGtA Pkinase_C X 9271; 3787; 4060; 4051; 5102; 4058; 2336; 2337; 4075; 4070; 5012; 4071; 92982; 5315; 9563; 9018; 12694; 52240; 11962; 15116; 88106; 26580; 68035; 31957; 23430; 20235 +PRKCB PKCB P05771 human p47phox 653361 P14598 NCF1 human S320 451726 QRsRKRLsQDAYRRN NECFESHC X +PRKCB PKCB P05771 human IBTK 25998 Q9P2D0 IBTK human S1200 21358401 ASSLHsVsSksFRDF X X +PRKCB PKCB P05771 human EphA2 1969 P29317 EPHA2 human S892 3189622 ADFDPRVsIRLPsts X X +PRKCB PKCB P05771 human Kv3.4 3749 Q03721 KCNC4 human S21 451078 KsGNKPPsKTCLKEE Potassium_chann X +PRKCB PKCB P05771 human AMPKA1 5562 Q13131 PRKAA1 human S496 450431 AtPQRsGsVsNyRSC AdenylateSensor X 4185; 4184; 2537 +PRKCB PKCB P05771 human AID 11628 Q9WVE0 Aicda mouse S3 20660600 _____MDsLLMKQKK X +PRKCB PKCB P05771 human CACNA1C 100101555 P15381 CACB rabbit S533 453091 RIsKSKFsRYWRRWN X +PRKCB PKCB P05771 human SHP-2 5781 Q06124 PTPN11 human S576 469622 CAEMREDsARVyENV X +PRKCB PKCB P05771 human NOX5 iso4 79400 Q96PH1-4 NOX5 human T494 472625 KRLsRSVtMRKsQRS FAD_binding_8 X +PRKCB PKCB P05771 human EPB41 iso4 2035 P11171-4 EPB41 human S312 455112 QAQTRQAsALIDRPA FA X +PRKCB PKCB P05771 human STMN1 3925 P16949 STMN1 human S25 448555 QAFELILsPrskEsV Stathmin X +PRKCB PKCB P05771 human TFEB 21425 Q9R210 Tfeb mouse S462 4785132 PEASKAssRRssFsM DUF3371 X +PRKCB PKCB P05771 human IRS1 16367 P35569 Irs1 mouse S318 451399 MVGGKPGsFRVRASs X 5610 +PRKCB PKCB P05771 human TYR 7299 P14679 TYR human S527 486440 DYHsLYQsHL_____ X X +PRKCB PKCB P05771 human Tau iso8 4137 P10636-8 MAPT human S324 449328 kVtskCGsLGNIHHk Tubulin-binding X +PRKCB PKCB P05771 human GSK3A 606496 Q2NL51 Gsk3a mouse S21 448584 sGRARtssFAEPGGG X 9337; 9316; 9331; 9327; 8452; 8566 +PRKCB PKCB P05771 human MARCKS 4082 P29966 MARCKS human S163 447787 KRFsFkKsFkLsGFs MARCKS X 2741; 11992 +PRKCB PKCB P05771 human RBCK1 Q62921 Rbck1 rat T161 2103604 DLGFKDLtLQPRGPL X +PRKCB PKCB P05771 human CHAT iso3 1103 P28329-3 CHAT human S440 449057 VPTYESAsIRRFQEG Carn_acyltransf X +PRKCB PKCB P05771 human STMN1 3925 P16949 STMN1 human S38 448556 sVPEFPLsPPkKkDL Stathmin X 3426; 4191 +PRKCB PKCB P05771 human GSK3B 56637 Q9WV60 Gsk3b mouse S9 449111 SGRPRttsFAEsCKP X 9336; 9331; 9327; 9323; 9322; 9325; 5558; 8566; 79774; 8466; 25462; 14026; 14332; 14310; 14630 +PRKCB PKCB P05771 human MSX2 4488 P35548 MSX2 human T135 25554905 HMsPTTCtLRKHKtN X X +PRKCB PKCB P05771 human RBCK1 Q62921 Rbck1 rat S270 2103606 HVQLEQRsLVLNtEP X +PRKCB PKCB P05771 human CHAT iso3 1103 P28329-3 CHAT human S347 454036 LKHVTQssRKLIRAD Carn_acyltransf X +PRKCB PKCB P05771 human CHAT iso3 1103 P28329-3 CHAT human T255 454038 TVLVKDStNRDSLDM Carn_acyltransf X +PRKCB PKCB P05771 human CARD11 108723 Q8CIS0 Card11 mouse S657 457639 LERPFRPsVTSGGHV X X 5189 +PRKCB PKCB P05771 human TYR 7299 P14679 TYR human S523 486439 MEKEDYHsLYQsHL_ X X +PRKCB PKCB P05771 human mGluR5 24418 P31424 Grm5 rat S839 455778 VRSAFTTstVVRMHV X +PRKCB PKCB P05771 human CARD11 108723 Q8CIS0 Card11 mouse S649 457638 NLMLRKFsLERPFRP X X +PRKCB PKCB P05771 human Tau iso8 4137 P10636-8 MAPT human S293 449327 NVQskCGsKDNIkHV Tubulin-binding X +PRKCB PKCB P05771 human p47phox 653361 P14598 NCF1 human S304 449406 GAPPRRssIRNAHsI NECFESHC X +PRKCB PKCB P05771 human TFEB 21425 Q9R210 Tfeb mouse S466 4785142 KAssRRssFsMEEGD DUF3371 X +PRKCB PKCB P05771 human SHC1 6464 P29353 SHC1 human T206 58109400 VPGAkGAtRRRKPCs PID X +PRKCB PKCB P05771 human GSK3A 2931 P49840 GSK3A human S21 448584 sGrARtssFAEPGGG X 9337; 9316; 9331; 5090; 9327; 8452; 8566 +PRKCB PKCB P05771 human IBTK 25998 Q9P2D0 IBTK human S1203 15483703 LHsVsSksFRDFLLE X X +PRKCB PKCB P05771 human TRPM8 79054 Q7Z2W7 TRPM8 human S1040 34360655 CKEKNMEssVCCFKN X +PRKCB PKCB P05771 human MARCKS 4082 P29966 MARCKS human S159 447786 kkKKKRFsFkKsFkL MARCKS X 2741; 11992 +PRKCB PKCB P05771 human ATP1A1 24211 P06685 Atp1a1 rat S23 449087 sEHGDkkskkAKKER X 4006 +PRKCB PKCB P05771 human NOX5 iso4 79400 Q96PH1-4 NOX5 human S498 472626 RSVtMRKsQRSsKGS FAD_binding_8 X +PRKCB PKCB P05771 human HNF4 alpha 25735 P22449 Hnf4a rat S87 478421 CKGFFRRsVRKNHMY zf-C4 X +PRKCB PKCB P05771 human GRN 2896 P28799 GRN human S81 41198100 IFTVSGTsSCCPFPE Granulin X +PRKCB PKCB P05771 human SHC1 6464 P29353 SHC1 human S213 58109401 tRRRKPCsRPLSSIL PID X +PRKCB PKCB P05771 human RASGRP3 421460 Q5ZID9 RASGRP3 chicken T133 454419 YDWMRRVtQRKKISK X +PRKCB PKCB P05771 human Tau iso8 4137 P10636-8 MAPT human S258 487453 PDLkNVKskIGstEN Tubulin-binding X +PRKCB PKCB P05771 human Kv3.4 3749 Q03721 KCNC4 human S8 451075 MISSVCVssYRGRKs Potassium_chann X +PRKCB PKCB P05771 human ATF-2 1386 P15336 ATF2 human S121 6406001 LAtPIIRsKIEEPSV X +PRKCB PKCB P05771 human GSK3B 2932 P49841 GSK3B human S9 449111 SGRPRttsFAEsCkP X 9336; 9331; 9327; 9323; 9322; 9325; 5558; 8566; 79774; 8466; 25462; 14026; 14332; 14310; 14630 +PRKCB PKCB P05771 human RBCK1 Q62921 Rbck1 rat S285 2103608 AECPVCYsVLAPGEA zf-RING_UBOX X +PRKCB PKCB P05771 human SNAP-25 25012 P60881 Snap25 rat S187 448668 RIMEkADsNkTRIDE X +PRKCB PKCB P05771 human TFEB 21425 Q9R210 Tfeb mouse S461 4785127 sPEASKAssRRssFs DUF3371 X +PRKCB PKCB P05771 human occludin 100506658 Q16625 OCLN human S490 6094300 RLKQVkGsADYKSKK Occludin_ELL X X +PRKCB PKCB P05771 human P70S6KB 6199 Q9UBS0 RPS6KB2 human S473 450071 PPSGTKKsKRGRGRP X X +PRKCB PKCB P05771 human ORAI1 84876 Q96D31 ORAI1 human S30 14932000 TTsGsRRsRRRsGDG X X +PRKCB PKCB P05771 human HMGA1 117062 Q8K585 Hmga1 rat S44 479856 PGTALVGsQKEPSEV X +PRKCB PKCB P05771 human MSX2 4488 P35548 MSX2 human T141 25554904 CtLRKHKtNRKPRTP X X +PRKCB PKCB P05771 human CFLAR iso2 8837 O15519-2 CFLAR human S193 7590803 LQAAIQKsLKDPSNN X +PRKCB PKCB P05771 human RBCK1 Q62921 Rbck1 rat T275 2103607 QRsLVLNtEPAECPV X +PRKCB PKCB P05771 human RBCK1 Q62921 Rbck1 rat S137 2103603 LLSARNTsLNPQELQ X +PRKCB PKCB P05771 human C5aR 728 P21730 C5AR1 human S334 448819 sVVREsKsFTRsTVD X X +PRKCB PKCB P05771 human Kv3.4 3749 Q03721 KCNC4 human S15 451077 ssYRGRKsGNKPPsK Potassium_chann X +PRKCB PKCB P05771 human Claudin-1 9076 O95832 CLDN1 human T191 1869121000 CSCPRkTtsYPtPRP X +PRKCB PKCB P05771 human KLHL3 26249 Q9UH77 KLHL3 human S433 36440206 PMNTRRSsVGVGVVE Kelch_1 X X +PRKCB PKCB P05771 human IRS1 3667 P35568 IRS1 human S323 451399 MVGGKPGsFRVRAss X 5610 +PRKCB PKCB P05771 human CACNA1C 100101555 P15381 CACB rabbit S528 486358 ARLAHRIsKSKFsRY X +PRKCB PKCB P05771 human SHC1 6464 P29353 SHC1 human S139 448791 EEWTRHGsFVNkPtR X X +PRKCB PKCB P05771 human p47phox 653361 P14598 NCF1 human S315 451725 AHsIHQRsRKRLsQD NECFESHC X +PRKCB PKCB P05771 human CFLAR 8837 O15519 CFLAR human S193 7590803 LQAAIQksLkDPSNN X +PRKCB PKCB P05771 human TRPM8 79054 Q7Z2W7 TRPM8 human S1041 34360658 KEKNMEssVCCFKNE X +PRKCB PKCB P05771 human p47phox 653361 P14598 NCF1 human S328 449404 QDAYRRNsVRFLQQR NECFESHC X +PRKCB PKCB P05771 human CHAT iso3 1103 P28329-3 CHAT human S476 454037 HKAAVPAsEKLLLLK Carn_acyltransf X +PRKCB PKCB P05771 human TFEB 21425 Q9R210 Tfeb mouse S468 4785147 ssRRssFsMEEGDVL DUF3371 X +PRKCB PKCB P05771 human CHAT iso3 1103 P28329-3 CHAT human S346 454035 LLKHVTQssRKLIRA Carn_acyltransf X +PRKCB PKCB P05771 human NFAT90 3609 Q12906 ILF3 human S647 3496801 rGrGRGGsIRGRGRG X X +PRKCB PKCB P05771 human H3 8350 P68431 H3C1 human T6 13321500 __ArtkQtArkstGG Histone X X +PRKCB PKCB P05771 human AID 11628 Q9WVE0 Aicda mouse T140 6835300 GVQIGIMtFKDYFYC APOBEC2 X +PRKCB PKCB P05771 human FCER1G 2207 P30273 FCER1G human S69 13310016 DGVytGLstRNQEty ITAM X +PRKCB PKCB P05771 human IRS1 3667 P35568 IRS1 human S441 1990800 SPCDFRSsFRsVtPD X +PRKCB PKCB P05771 human GLUT1 24778 P11167 Slc2a1 rat S226 10827359 NEENRAKsVLKKLRG Sugar_tr X +PRKCB PKCB P05771 human ACSL4 2182 O60488 ACSL4 human T328 1876129100 LAHVLELtAEISCFT AMP-binding X X +PRKCB PKCB P05771 human CACNA1C 100101555 P15381 CACB rabbit S1674 480102 QGLVGKPsQRNALSL X X +PRKCB PKCB P05771 human RBCK1 Q62921 Rbck1 rat T207 2103605 CTFINKPtRPGCEMC X +PRKCB PKCB P05771 human occludin 18260 Q61146 Ocln mouse S489 6094300 RLKQVKGsADYKSKR Occludin_ELL X +PRKCB PKCB P05771 human HMGA1 117062 Q8K585 Hmga1 rat S64 3136103 PRGRPKGsKNKGTAK X +PRKCB PKCB P05771 human Akt1 207 P31749 AKT1 human T308 447856 kDGAtMKtFCGtPEy Pkinase X 5106; 2965; 9275; 4056; 5056; 13842; 13038; 43506; 48646; 86758; 80722; 77440; 80556 +Ephb3 EphB3 P54754 mouse NCAM-L1 16728 P11627 L1cam mouse Y1232 10272401 DGsFIGQySGKKEKE Bravo_FIGEY X +Tesk2 TESK2 Q924U5 rat Cofilin-1 29271 P45592 Cfl1 rat S3 448444 _____MAsGVAVsDG X X 3313; 3311 +PBK PBK Q96KB5 human PRPK 112858 Q96S44 TP53RK human S250 1981300 RLRGRKRsMVG____ X X +PBK PBK Q96KB5 human ULK1 8408 O75385 ULK1 human S469 483137 IRRsGstsPLGFARA X X +PBK PBK Q96KB5 human H3 8350 P68431 H3C1 human S10 455676 tkQtArkstGGkAPr Histone X X 9701; 9711; 9606; 3465; 3642; 3377; 3475; 3458; 5764; 47398; 8481; 8552; 53348; 29237; 66065; 43185; 64522; 52725 +PBK PBK Q96KB5 human YB-1 4904 P67809 YBX1 human T89 36130583 EDVFVHQtAIkkNNP CSD X X +PBK PBK Q96KB5 human Jun 3725 P05412 JUN human S73 447943 VGLLkLAsPELERLI Jun X X 9164; 3270; 8752; 12714; 77955 +PBK PBK Q96KB5 human YB-1 4904 P67809 YBX1 human S209 7998039 YGrrPQysNPPVQGE X X +PBK PBK Q96KB5 human Jun 3725 P05412 JUN human S63 447686 kNsDLLtsPDVGLLk Jun X X 5464; 9261; 2361; 97721; 91952 +PBK PBK Q96KB5 human GPSM2 29899 P81274 GPSM2 human T457 18412000 LKGKKYKtNsstkVL X X +PBK PBK Q96KB5 human PRDX1 5052 Q06830 PRDX1 human S32 15334103 QFkDIsLsDykGkYV AhpC-TSA X X +PBK PBK Q96KB5 human ULK1 8408 O75385 ULK1 human S533 31868990 AEMrGGRsPRPGssA X X +PBK PBK Q96KB5 human ULK1 8408 O75385 ULK1 human S495 6220991 GVLARKMsLGGGRPY X X +Camkk2 CAMKK2 Q8C078 mouse AMPKA1 65248 P54645 Prkaa1 rat T183 448786 SDGEFLRtsCGSPNY Pkinase X 2535; 2531; 4188; 5256; 50081; 74281 +Camkk2 CAMKK2 Q8C078 mouse AMPKA1 105787 Q5EG47 Prkaa1 mouse T183 448786 sDGEFLRtsCGsPNY Pkinase X 2535; 2531; 4188; 5256; 50081; 74281 +PASK PASK Q96RG2 human PASK 23178 Q96RG2 PASK human T1165 454397 LFYtFCGtIEYCAPE Pkinase X +PASK PASK Q96RG2 human PASK 23178 Q96RG2 PASK human T1161 454396 ERGKLFYtFCGtIEY Pkinase X +PASK PASK Q96RG2 human EEF1A1 1915 P68104 EEF1A1 human T432 2862100 AVRDMrQtVAVGVIk GTP_EFTU_D3 X +PASK PASK Q96RG2 human PASK 23178 Q96RG2 PASK human T307 1868450201 VGRARDGtTFPLSLk X +PASK PASK Q96RG2 human WDR5 11091 P61964 WDR5 human S49 25758598 AGHTkAVsSVKFsPN WD40 X +PASK PASK Q96RG2 human GYS1 100008660 P13834 GYS1 rabbit S641 448237 YRYPRPAsVPPsPSL Glycogen_syn X +PASK PASK Q96RG2 human PDX1 18609 P52946 Pdx1 mouse T152 470134 EENKRTRtAYTRAQL Homeodomain X +Atm ATM D4ACL8 rat DBN1 81653 Q07266 Dbn1 rat S659 472365 SEGYFSQsQEEEFAQ X +EIF2AK3 PERK Q9NZJ5 human PERK 13666 Q9Z2B5 Eif2ak3 mouse Y561 30310301 QCQTESKyDSVSADV X X +EIF2AK3 PERK Q9NZJ5 human FBPase 2203 P09467 FBP1 human S170 1880113501 AGYALYGsATMLVLA X X +EIF2AK3 PERK Q9NZJ5 human PERK 9451 Q9NZJ5 EIF2AK3 human T982 447936 MPAYARHtGQVGTKL Pkinase X +EIF2AK3 PERK Q9NZJ5 human eIF2-alpha 1965 P05198 EIF2S1 human S49 450210 IEGMILLsELsRRRI S1 X +EIF2AK3 PERK Q9NZJ5 human eIF2-alpha 13665 Q6ZWX6 Eif2s1 mouse S52 447635 MILLSELsRrrIRSI S1 X X 3597; 9721; 3398; 5199; 53085; 95797 +EIF2AK3 PERK Q9NZJ5 human eIF2-alpha 1965 P05198 EIF2S1 human S52 447635 MILLsELsRRRIRsI S1 X X 3597; 9721; 3398; 5199; 53085; 95797 +EIF2AK3 PERK Q9NZJ5 human PERK 13666 Q9Z2B5 Eif2ak3 mouse Y615 1256400 NKVDDCNyAIKRIRL Pkinase X X +Insr INSR P15208 mouse STXBP3 20912 Q60770 Stxbp3 mouse Y521 459181 RQKPRTNyLELDRKN Sec1 X +Insr INSR P15208 mouse APS 23921 Q9JID9 Sh2b2 mouse Y618 448842 ARAVENQySFY____ X +Insr INSR P15208 mouse FABP4 11770 P04117 Fabp4 mouse Y20 451170 sSENFDDyMkEVGVG Lipocalin X +Insr INSR P15208 mouse caveolin-1 12389 P49817 Cav1 mouse Y14 448422 VDsEGHLytVPIREQ X 3251 +BRAF BRAF P15056 human NHE1 6548 P19634 SLC9A1 human T653 4729330 LRsYNRHtLVADPyE NEXCaM_BD X X +BRAF BRAF P15056 human EEF1A1 1915 P68104 EEF1A1 human T88 15229616 EtSkyyVtIIDAPGH GTP_EFTU X +BRAF BRAF P15056 human BRAF 673 P15056 BRAF human S465 4959522 tVGQRIGsGsFGtVY PK_Tyr_Ser-Thr X +BRAF BRAF P15056 human MEK1 5604 Q02750 MAP2K1 human S222 448513 LIDsMANsFVGtRSY Pkinase X X 2338; 9121; 3958; 9154; 16211; 86128; 16780; 75262 +BRAF BRAF P15056 human EEF1A2 1917 Q05639 EEF1A2 human S21 5434143 GHVDSGkstttGHLI GTP_EFTU X +BRAF BRAF P15056 human MEK1 5604 Q02750 MAP2K1 human S218 448514 VsGQLIDsMANsFVG Pkinase X X 9121; 3958; 9154; 86128 +BRAF BRAF P15056 human TTK 7272 P33981 TTK human S281 1737603 VPVNLLNsPDCDVkt X +BRAF BRAF P15056 human BAD 572 Q92934 BAD human S99 447862 PFrGrsRsAPPNLWA Bcl-2_BAD X X 9295; 5286; 4366 +BRAF BRAF P15056 human MEK2 5605 P36507 MAP2K2 human S222 448073 VsGQLIDsMANsFVG Pkinase X 9121; 3958; 9154; 86128 +BRAF BRAF P15056 human BAD 572 Q92934 BAD human S75 447860 EIRsRHssyPAGtED Bcl-2_BAD X X 9291; 5284; 9296; 5193; 11865; 94223 +BRAF BRAF P15056 human NANOG 79923 Q9H9S0 NANOG human S68 1394461701 LIQDsPDsStsPKGK X X +BRAF BRAF P15056 human EEF1A1 1915 P68104 EEF1A1 human S21 5434136 GHVDSGkstttGHLI GTP_EFTU X +BRAF BRAF P15056 human BRAF 673 P15056 BRAF human S614 14159399 SHQFEQLsGSILWMA PK_Tyr_Ser-Thr X +BRAF BRAF P15056 human BAD 572 Q92934 BAD human S118 447863 GRELRRMsDEFVDsF Bcl-2_BAD X X 9297 +BRAF BRAF P15056 human BRAF 673 P15056 BRAF human S467 28070701 GQRIGsGsFGtVYkG PK_Tyr_Ser-Thr X +BRAF BRAF P15056 human BRAF 673 P15056 BRAF human T373 458858 APNVHINtIEPVNID X +BRAF BRAF P15056 human MEK2 5605 P36507 MAP2K2 human S226 448074 LIDsMANsFVGtRSY Pkinase X 2338; 9121; 3958; 9154; 16211; 86128; 16780; 75262 +BRAF BRAF P15056 human TTK 7272 P33981 TTK human S436 950200 VFSVskQsPPIsTSk X +BRAF BRAF P15056 human BAD 572 Q92934 BAD human S134 447864 KGLPRPKsAGtAtQM Bcl-2_BAD X X +NEK9 NEK9 Q8TD19 human CSN2 281099 P02666 CSN2 cow S157 2869600 LPLPLLQsWMHQPHQ Casein X +NEK9 NEK9 Q8TD19 human NEK9 91754 Q8TD19 NEK9 human S944 4272073 GQQVGMHskGTQTAK X X +NEK9 NEK9 Q8TD19 human CSN2 281099 P02666 CSN2 cow S72 11334000 HPFAQTQsLVYPFPG X +NEK9 NEK9 Q8TD19 human CSN2 281099 P02666 CSN2 cow S139 2869601 EPFTESQsLTLTDVE Casein X +NEK9 NEK9 Q8TD19 human NEDD1 121441 Q8NHV4 NEDD1 human S377 12737836 EkAGLPRsINTDtLS X +NEK9 NEK9 Q8TD19 human LC3B 81631 Q9GZQ8 MAP1LC3B human T50 37045604 QLPVLDktkFLVPDH ATG8 X X +NEK9 NEK9 Q8TD19 human NEK7 140609 Q8TDX7 NEK7 human S195 4271152 skttAAHsLVGtPyy Pkinase X +NEK9 NEK9 Q8TD19 human NEK6 10783 Q9HC98 NEK6 human S206 448024 sEttAAHsLVGtPyy Pkinase X X +NEK9 NEK9 Q8TD19 human NEK9 91754 Q8TD19 NEK9 human T210 451116 SEYsMAEtLVGtPYY Pkinase X X +MYLK smMLCK Q15746 human MRLC2V 4633 P10916 MYL2 human S15 2846506 KRAGGANsNVFsMFE X X +MYLK smMLCK Q15746 human MRLC1 10398 P24844 MYL9 human T19 1863501 KKRPQRAtsNVFAMF X 3674; 95777 +MYLK smMLCK Q15746 human Caldesmon 373965 P12957 CALD1 chicken T693 3194456 TGtPNKEtAGLKVGV Caldesmon X +MYLK smMLCK Q15746 human Caldesmon 373965 P12957 CALD1 chicken S73 457422 SEVNAQNsVAEEETK Caldesmon X +MYLK smMLCK Q15746 human Caldesmon 373965 P12957 CALD1 chicken S702 456707 GLKVGVSsRINEWLT Caldesmon X +MYLK smMLCK Q15746 human MRLC2 103910 O14950 MYL12B human S20 448595 KRPQRAtsNVFAMFD X X +MYLK smMLCK Q15746 human Caldesmon 373965 P12957 CALD1 chicken T626 14823409 SGMKPAHttAVVsKI Caldesmon X +MYLK smMLCK Q15746 human MRLC1 10398 P24844 MYL9 human S20 1863500 KRPQRAtsNVFAMFD X 3674; 3671; 3675; 95777 +MYLK smMLCK Q15746 human Caldesmon 373965 P12957 CALD1 chicken S658 14823410 KPAKPAAsDLPVPAE Caldesmon X +MYLK smMLCK Q15746 human MRLC2 103910 O14950 MYL12B human T19 448596 KKRPQRAtsNVFAMF X +MYLK smMLCK Q15746 human MRLC2 50685 P18666 Myl12b rat S20 448595 KRPQRAtsNVFAMFD X +Cdc42bpa MRCKA O54874 rat LIMK2 29524 P53670 Limk2 rat T505 448683 SDRKKRYtVVGNPYW PK_Tyr_Ser-Thr X 3841 +CDK15 CDK15 Q96Q40 human PAK4 10298 O96013 PAK4 human S291 2192537 PGPPGPRsPQREPQR X X +Uhmk1 KIS Q63285 rat MBP 618684 P02687 MBP cow S164 451833 GRDsRSGsPMARR__ Myelin_MBP X +Uhmk1 KIS Q63285 rat SYN1 281510 P17599 SYN1 cow S438 2020553 GSHSQTPsPGALPLG X +Uhmk1 KIS Q63285 rat PAM 25508 P14925 Pam rat S949 453092 DRVstEGsDQEKDED X X +KHK KHK P50053 human 14-3-3 eta 7533 Q04917 YWHAH human S25 14159200 ERyDDMAsAMKAVTE 14-3-3 X X +Zap70 ZAP70 P43404 mouse LAT 16797 O54957 Lat mouse Y136 447760 EDDyPNGyLVVLPDS LAT X +Zap70 ZAP70 P43404 mouse LAT 16797 O54957 Lat mouse Y175 448004 SVESCEDyVNVPESE LAT X 3581 +Zap70 ZAP70 P43404 mouse LAT 16797 O54957 Lat mouse Y235 448006 DGEEAPDyENLQELN LAT X 54364; 45170 +Zap70 ZAP70 P43404 mouse LAT 16797 O54957 Lat mouse Y195 448005 SLDGSREyVNVsPEQ LAT X 3584; 20172 +Grk1 GRK1 Q9WVL4 mouse Rhodopsin 212541 P15409 Rho mouse S338 448679 DDAsATAsKtEtsQV X X +Grk1 GRK1 Q9WVL4 mouse Rhodopsin 212541 P15409 Rho mouse S334 448677 PLGDDDAsATAsKtE X +Cdc7 CDC7 Q9Z0H0 mouse NHEJ1 75570 Q3KNJ2 Nhej1 mouse S245 4084901 TQASSSTsPRGTDNQ X +Hipk4 HIPK4 Q3V016 mouse NDEL1 83431 Q9ERR1 Ndel1 mouse S336 1869686801 LGSsRPSsAPGMLPL X +PRKCG PKCG P05129 human HSP90A 3320 P07900 HSP90AA1 human T115 13256102 GtIAksGtkAFMEAL HATPase_c X X +PRKCG PKCG P05129 human DNAJC5 80331 Q9H3Z4 DNAJC5 human S34 10407117 TSDDIKKsYRKLALk DnaJ X X +PRKCG PKCG P05129 human Tau iso8 4137 P10636-8 MAPT human S352 487459 DFKDrVQskIGsLDN Tubulin-binding X +PRKCG PKCG P05129 human DAB2 1601 P98082 DAB2 human S24 451211 QAAPKAPsKKEKKKG X +PRKCG PKCG P05129 human CACNA1C 100101555 P15381 CACB rabbit S1928 455278 ASLGRRAsFHLECLK CAC1F_C X +PRKCG PKCG P05129 human Kv3.4 3749 Q03721 KCNC4 human S9 451076 ISSVCVssYRGRKsG Potassium_chann X +PRKCG PKCG P05129 human SYN1 20964 O88935 Syn1 mouse S553 448377 ArPPAsPsPQrQAGA X +PRKCG PKCG P05129 human GluR4 29629 P19493 Gria4 rat S862 448810 TRNKARLsITGSVGE X +PRKCG PKCG P05129 human MOR-1 18390 P42866 Oprm1 mouse S363 447783 STIEQQNsARIRQNt X +PRKCG PKCG P05129 human Kv3.4 3749 Q03721 KCNC4 human S21 451078 KsGNKPPsKTCLKEE Potassium_chann X +PRKCG PKCG P05129 human AID 11628 Q9WVE0 Aicda mouse S3 20660600 _____MDsLLMKQKK X +PRKCG PKCG P05129 human CACNA1C 100101555 P15381 CACB rabbit S533 453091 RIsKSKFsRYWRRWN X +PRKCG PKCG P05129 human SYN1 20964 O88935 Syn1 mouse S551 451574 PAArPPAsPsPQrQA X +PRKCG PKCG P05129 human HSP90A 3320 P07900 HSP90AA1 human T425 30957300 KkCLELFtELAEDkE HSP90 X X +PRKCG PKCG P05129 human Tau iso8 4137 P10636-8 MAPT human S324 449328 kVtskCGsLGNIHHk Tubulin-binding X +PRKCG PKCG P05129 human SLC38A3 252919 Q9JHZ9 Slc38a3 rat S52 19001700 KGFLQQSsSKEPHFT X +PRKCG PKCG P05129 human DRAK2 170904 Q91XS8 Stk17b rat S350 1735800 PEDDSLLsKRFRFDD X X +PRKCG PKCG P05129 human MLP 17357 P28667 Marcksl1 mouse S93 477961 PKKKKKFsFKKPFKL MARCKS X +PRKCG PKCG P05129 human CHAT iso3 1103 P28329-3 CHAT human S440 449057 VPTYESAsIRRFQEG Carn_acyltransf X +PRKCG PKCG P05129 human CHAT iso3 1103 P28329-3 CHAT human S347 454036 LKHVTQssRKLIRAD Carn_acyltransf X +PRKCG PKCG P05129 human NGFR 4804 P08138 NGFR human S277 9993601 IAFKRWNsCKQNKQG TNFR_16_TM X +PRKCG PKCG P05129 human CHAT iso3 1103 P28329-3 CHAT human T255 454038 TVLVKDStNRDSLDM Carn_acyltransf X +PRKCG PKCG P05129 human mGluR5 24418 P31424 Grm5 rat S839 455778 VRSAFTTstVVRMHV X +PRKCG PKCG P05129 human Tau iso8 4137 P10636-8 MAPT human S293 449327 NVQskCGsKDNIkHV Tubulin-binding X +PRKCG PKCG P05129 human GSK3A 2931 P49840 GSK3A human S21 448584 sGrARtssFAEPGGG X 9337; 9316; 9331; 5090; 9327; 8452; 8566 +PRKCG PKCG P05129 human HNF4 alpha 25735 P22449 Hnf4a rat S87 478421 CKGFFRRsVRKNHMY zf-C4 X +PRKCG PKCG P05129 human fascin 14086 Q61553 Fscn1 mouse S39 450888 KVNASAssLkkKQIW Fascin X +PRKCG PKCG P05129 human Tau iso8 4137 P10636-8 MAPT human S258 487453 PDLkNVKskIGstEN Tubulin-binding X +PRKCG PKCG P05129 human Kv3.4 3749 Q03721 KCNC4 human S8 451075 MISSVCVssYRGRKs Potassium_chann X +PRKCG PKCG P05129 human NADK 65220 O95544 NADK human S64 467326 kEFRRtRsLHGPCPV X X +PRKCG PKCG P05129 human KIR3DL1 3811 P43629 KIR3DL1 human S415 990302 QRKITRPsQRPKtPP X +PRKCG PKCG P05129 human GSK3B 2932 P49841 GSK3B human S9 449111 SGRPRttsFAEsCkP X 9336; 9331; 9327; 9323; 9322; 9325; 5558; 8566; 79774; 8466; 25462; 14026; 14332; 14310; 14630 +PRKCG PKCG P05129 human TRPC3 7222 Q13507 TRPC3 human T646 20612407 LQISLGRtVKDIFKF Ion_trans X +PRKCG PKCG P05129 human MMP14 4323 P50281 MMP14 human T567 7992400 FFFRRHGtPRRLLyC DUF3377 X +PRKCG PKCG P05129 human P70S6KB 6199 Q9UBS0 RPS6KB2 human S473 450071 PPSGTKKsKRGRGRP X X +PRKCG PKCG P05129 human ARHGEF7 8874 Q14155 ARHGEF7 human S518 454356 LSASPRMsGFIYQGK PH X X +PRKCG PKCG P05129 human HMGA1 117062 Q8K585 Hmga1 rat S44 479856 PGTALVGsQKEPSEV X +PRKCG PKCG P05129 human GJA1 24392 P08050 Gja1 rat S368 447813 QRPssRAssRAssRP X 3511; 52559 +PRKCG PKCG P05129 human GRK2 156 P25098 GRK2 human S29 447724 ATPAARAskkILLPE X +PRKCG PKCG P05129 human C5aR 728 P21730 C5AR1 human S334 448819 sVVREsKsFTRsTVD X +PRKCG PKCG P05129 human Kv3.4 3749 Q03721 KCNC4 human S15 451077 ssYRGRKsGNKPPsK Potassium_chann X +PRKCG PKCG P05129 human CACNA1C 100101555 P15381 CACB rabbit S528 486358 ARLAHRIsKSKFsRY X +PRKCG PKCG P05129 human DNAJC5 80331 Q9H3Z4 DNAJC5 human S10 448129 DQRQRsLstsGEsLy X X +PRKCG PKCG P05129 human APTX 54840 Q7Z2E3 APTX human T125 9397200 AKNPGLEtHRKRKRs X X +PRKCG PKCG P05129 human CD5 921 P06127 CD5 human T434 450129 MsFHRNHtAtVRsHA X +PRKCG PKCG P05129 human CHAT iso3 1103 P28329-3 CHAT human S476 454037 HKAAVPAsEKLLLLK Carn_acyltransf X +PRKCG PKCG P05129 human GLRB 14658 P48168 Glrb mouse S425 2048205 NDFSIVGsLPRDFEL Neur_chan_memb X +PRKCG PKCG P05129 human HSP90A 3320 P07900 HSP90AA1 human T603 12078914 PCCIVtstyGWtANM HSP90 X X +PRKCG PKCG P05129 human CHAT iso3 1103 P28329-3 CHAT human S346 454035 LLKHVTQssRKLIRA Carn_acyltransf X +PRKCG PKCG P05129 human ARHGEF7 8874 Q14155 ARHGEF7 human S761 14569926 DSLGRRSsLsRLEPS X X +PRKCG PKCG P05129 human MLP 17357 P28667 Marcksl1 mouse S104 465848 PFKLsGLsFkRNRkE MARCKS X +PRKCG PKCG P05129 human CACNA1C 100101555 P15381 CACB rabbit S1674 480102 QGLVGKPsQRNALSL X +PRKCG PKCG P05129 human CD5 921 P06127 CD5 human T436 450130 FHRNHtAtVRsHAEN X +PRKCG PKCG P05129 human NADK 65220 O95544 NADK human S46 1210510 RGRAKsrsLsAsPAL X X +PRKCG PKCG P05129 human HMGA1 117062 Q8K585 Hmga1 rat S64 3136103 PRGRPKGsKNKGTAK X +Akt2 Akt2 P47197 rat SFRS5 29667 Q09167 Srsf5 rat S86 3685800 GRGRGRYsDRFSSRR X +Akt2 Akt2 P47197 rat S6 29304 P62755 Rps6 rat S235 448092 IAKRRRLssLRAsts X 5006; 4856; 4857; 4858; 4851; 4803; 2211; 3945; 3985; 5316; 4854; 8520; 48319; 40643; 9865; 38573; 14733; 27036; 34411; 62016; 62788; 81736; 97935; 99457; 15448 +Akt2 Akt2 P47197 rat S6 29304 P62755 Rps6 rat S236 448093 AKRRRLssLRAstsK X 5006; 4856; 4857; 4858; 4851; 4803; 2211; 3945; 3985; 5316; 4854; 8520; 48319; 40643; 9865; 38573; 14733; 27036; 34411; 62016; 62788; 81736; 97935; 99457; 15448 +VRK3 VRK3 Q8IV63 human BAF 8815 O75531 BANF1 human S4 458302 ____MttsQkHRDFV BAF X X +FLT3 FLT3 P36888 human FLT3 2322 P36888 FLT3 human Y955 454873 ADAEEAMyQNVDGRV X +FLT3 FLT3 P36888 human FLT3 2322 P36888 FLT3 human Y726 448644 kEHNFSFyPtFQSHP PK_Tyr_Ser-Thr X +FLT3 FLT3 P36888 human FLT3 2322 P36888 FLT3 human Y591 448190 SSDNEyFyVDFREyE X 3474; 3466; 3461; 3464; 48437; 25619; 23991; 60413 +FLT3 FLT3 P36888 human SIRT3 23410 Q9NTG7 SIRT3 human Y226 1881476100 KGLLLRLyTQNIDGL X +FLT3 FLT3 P36888 human EphB6 418308 Q07497 EPHB6 chicken Y594 449769 SKRRETPyTDRLQQy EphA2_TM X +FLT3 FLT3 P36888 human IDH1 3417 O75874 IDH1 human Y391 462261 PNVQRsDyLNTFEFM Iso_dh X +FLT3 FLT3 P36888 human IDH2 3418 P48735 IDH2 human Y107 1914598 sALATQkysVAVkCA Iso_dh X +FLT3 FLT3 P36888 human FLT3 2322 P36888 FLT3 human Y969 454874 VSECPHtyQNrrPFS X 3463 +FLT3 FLT3 P36888 human SHP-2 5781 Q06124 PTPN11 human Y62 449573 KIQNtGDyyDLyGGE SH2 X +FLT3 FLT3 P36888 human FLT3 2322 P36888 FLT3 human Y842 454872 DIMSDsNyVVRGNAR PK_Tyr_Ser-Thr X 4577 +FLT3 FLT3 P36888 human FLT3 2322 P36888 FLT3 human Y599 448643 VDFREyEyDLkWEFP X +FLT3 FLT3 P36888 human FLT3 2322 P36888 FLT3 human Y589 448189 TGSSDNEyFyVDFRE X 3464; 48437; 25619; 23991; 60413 +FLT3 FLT3 P36888 human PDHA1 5160 P08559 PDHA1 human Y301 454753 MsDPGVsyRtREEIQ E1_dh X +FLT3 FLT3 P36888 human PDHK1 5163 Q15118 PDK1 human Y243 462384 ARRLCDLyyINSPEL X +FLT3 FLT3 P36888 human EphB6 418308 Q07497 EPHB6 chicken Y601 461924 yTDRLQQyISTRGLG EphA2_TM X +Jak1 JAK1 P52332 mouse SH2-B-beta 89817 Q62985 Sh2b1 rat Y439 448753 DRLSQGAyGGLSDRP X +Jak1 JAK1 P52332 mouse SHP-2 19247 P35235 Ptpn11 mouse Y327 451496 NSKPKKSyIATQGCL Y_phosphatase X +Jak1 JAK1 P52332 mouse SH2-B-beta 89817 Q62985 Sh2b1 rat Y494 448754 VHPLSTPyPPLDTPE X +Jak1 JAK1 P52332 mouse SHP-2 19247 P35235 Ptpn11 mouse Y304 451495 PNEPVSDyINANIIM Y_phosphatase X +Jak1 JAK1 P52332 mouse GSK3B 56637 Q9WV60 Gsk3b mouse Y216 448569 RGEPNVsyICsRYYR Pkinase X +Jak1 JAK1 P52332 mouse IL7R 16197 P16872 Il7r mouse Y449 451291 VLNQEEAyVTMSSFY X +SRPK1 SRPK1 Q96SB4 human LBR G1N806 LBR turkey S78 18911472 SPSRRSRsRsRsRsP X +SRPK1 SRPK1 Q96SB4 human SRPK1 6732 Q96SB4 SRPK1 human S309 468861 RPNKQEEsEsPVERP X X +SRPK1 SRPK1 Q96SB4 human SF2 6426 Q07955 SRSF1 human S219 2303913 RsRsRsRsNsRsRsy X +SRPK1 SRPK1 Q96SB4 human SRPK1 6732 Q96SB4 SRPK1 human S33 3209895 sEtQHRGsAPHsEsD X X +SRPK1 SRPK1 Q96SB4 human LBR G1N806 LBR turkey S84 14575424 RsRsRsRsPGRPAKG X +SRPK1 SRPK1 Q96SB4 human SF2 6426 Q07955 SRSF1 human S209 2303911 yGRsRsRsRsRsRsR X +SRPK1 SRPK1 Q96SB4 human SF2 6426 Q07955 SRSF1 human S223 2303916 RsRsNsRsRsysPRR X +SRPK1 SRPK1 Q96SB4 human SF2 6426 Q07955 SRSF1 human S215 2303908 RsRsRsRsRsRsNsR X +SRPK1 SRPK1 Q96SB4 human RBM8A 9939 Q9Y5S9 RBM8A human S168 456535 GGRRRsRsPDRRRR_ X +SRPK1 SRPK1 Q96SB4 human SF2 6426 Q07955 SRSF1 human S207 2303910 PsyGRsRsRsRsRsR X +SRPK1 SRPK1 Q96SB4 human RBM20 309544 E9PT37 Rbm20 rat S638 31086436 YGPERPRsRsPMsRs X X +SRPK1 SRPK1 Q96SB4 human SRPK1 6732 Q96SB4 SRPK1 human S587 25724400 LIVAGkYskEFFTKK Pkinase X +SRPK1 SRPK1 Q96SB4 human RBM8A 9939 Q9Y5S9 RBM8A human S166 456534 RRGGRRRsRsPDRRR X +SRPK1 SRPK1 Q96SB4 human RBM4 5936 Q9BWF3 RBM4 human S309 476783 SyYGRDRsPLRRATA X +SRPK1 SRPK1 Q96SB4 human LBR G1N806 LBR turkey S82 14575430 RSRsRsRsRsPGRPA X +SRPK1 SRPK1 Q96SB4 human SF2 6426 Q07955 SRSF1 human S225 2303914 RsNsRsRsysPRRsR X +SRPK1 SRPK1 Q96SB4 human LBR G1N806 LBR turkey S80 14575427 SRRSRsRsRsRsPGR X +SRPK1 SRPK1 Q96SB4 human SF2 6426 Q07955 SRSF1 human S211 2303912 RsRsRsRsRsRsRsR X +SRPK1 SRPK1 Q96SB4 human SF2 6426 Q07955 SRSF1 human S213 2303907 RsRsRsRsRsRsRsN X +SRPK1 SRPK1 Q96SB4 human SF2 6426 Q07955 SRSF1 human S221 2303917 RsRsRsNsRsRsysP X +SRPK1 SRPK1 Q96SB4 human SF2 6426 Q07955 SRSF1 human S217 2303909 RsRsRsRsRsNsRsR X +SRPK1 SRPK1 Q96SB4 human SF2 6426 Q07955 SRSF1 human S227 2303915 NsRsRsysPRRsRGs X +SRPK1 SRPK1 Q96SB4 human SRPK1 6732 Q96SB4 SRPK1 human T326 25724401 ENPPNKMtQEKLEEs X X +SRPK1 SRPK1 Q96SB4 human SF2 6426 Q07955 SRSF1 human S205 454790 RsPsyGRsRsRsRsR X +SRPK1 SRPK1 Q96SB4 human RBM20 309544 E9PT37 Rbm20 rat S640 31086439 PERPRsRsPMsRsLS X X +Pdpk1 PDK1 O55173 rat SGK1 29517 Q06226 Sgk1 rat T256 448431 EHNGTTstFCGTPEY Pkinase X +Pdpk1 PDK1 O55173 rat PKCZ 25522 P09217 Prkcz rat T560 447572 TSEPVQLtPDDEDVI Pkinase_C X X +Pdpk1 PDK1 O55173 rat p70S6K 83840 P67999 Rps6kb1 rat T412 448607 NQVFLGFtYVAPSVL Pkinase_C X 9206; 9234; 9205; 97596 +Pdpk1 PDK1 O55173 rat PKCZ 25522 P09217 Prkcz rat T410 447510 GPGDTTStFCGTPNY Pkinase X X 9378; 2060 +Pdpk1 PDK1 O55173 rat KIDINS220 116478 Q9EQG6 Kidins220 rat S918 451418 RTITRQMsFDLTKLL KAP_NTPase X +PRKCZ PKCZ Q05513 human PTEN 5728 P60484 PTEN human S380 448313 EPDHyRYsDttDsDP X 9551; 9554; 9549; 7960 +PRKCZ PKCZ Q05513 human MARK2 2011 Q7KZI7 MARK2 human T596 453427 rGVssRstFHAGQLR X X +PRKCZ PKCZ Q05513 human CABP4 73660 Q8VHC5 Cabp4 mouse S37 1315600 PALTRRRsKKESWHP X X +PRKCZ PKCZ Q05513 human Tau iso8 4137 P10636-8 MAPT human S352 487459 DFKDrVQskIGsLDN Tubulin-binding X +PRKCZ PKCZ Q05513 human RhoE 390 P61587 RND3 human S210 27933600 KNVKRNKsQRATKRI X +PRKCZ PKCZ Q05513 human BVR 644 P53004 BLVRA human S230 478716 LKRNRyLsFHFksGs Biliv-reduc_cat X X +PRKCZ PKCZ Q05513 human Notch 1 18128 Q01705 Notch1 mouse S1791 35502500 LkPLKNAsDGALMDD X X +PRKCZ PKCZ Q05513 human TNNI3 511094 P08057 TNNI3 cow S44 450690 AKKKSKIsAsRKLQL X +PRKCZ PKCZ Q05513 human CACNA1C 100101555 P15381 CACB rabbit S1928 455278 ASLGRRAsFHLECLK CAC1F_C X +PRKCZ PKCZ Q05513 human GSK3B 2932 P49841 GSK3B human S147 51621301 YRVARHYsRAKQTLP Pkinase X +PRKCZ PKCZ Q05513 human NUMB iso3 8650 P49757-3 NUMB human S7 487518 _MNKLRQsFRRKKDV X +PRKCZ PKCZ Q05513 human LKB1 iso2 6794 Q15831-2 STK11 human S399 27933602 DLSGEEAsRPAPQ__ X X +PRKCZ PKCZ Q05513 human ATP1B1 25650 P07340 Atp1b1 rat S11 29573988 GKAkEEGsWkkFIWN Na_K-ATPase X +PRKCZ PKCZ Q05513 human AQP9 366 O43315 AQP9 human S222 477184 MNPARDLsPRLFTAL MIP X +PRKCZ PKCZ Q05513 human ATP1A1 24211 P06685 Atp1a1 rat S16 449086 KyEPAAVsEHGDkks X 4020 +PRKCZ PKCZ Q05513 human SRC-3 8202 Q9Y6Q9 NCOA3 human S1042 4252806 DDLVGPPsNLEGQsD X +PRKCZ PKCZ Q05513 human occludin 100506658 Q16625 OCLN human T438 19083405 LYKRNFDtGLQEyKs Occludin_ELL X X +PRKCZ PKCZ Q05513 human MARK3 4140 P27448 MARK3 human T564 466001 RGTASRStFHGQPRE X X +PRKCZ PKCZ Q05513 human PLA2G4A 5321 P47712 PLA2G4A human T376 1869344400 GskFFMGtVVKKYEE PLA2_B X +PRKCZ PKCZ Q05513 human PAK4 10298 O96013 PAK4 human S99 2192540 MsVTRsNsLRRDsPP X X +PRKCZ PKCZ Q05513 human PPP1R14A 94274 Q96A00 PPP1R14A human T38 449098 QkRHARVtVkYDRRE PP1_inhibitor X +PRKCZ PKCZ Q05513 human p47phox 653361 P14598 NCF1 human S320 451726 QRsRKRLsQDAYRRN NECFESHC X +PRKCZ PKCZ Q05513 human EphA2 1969 P29317 EPHA2 human S892 3189622 ADFDPRVsIRLPsts X X +PRKCZ PKCZ Q05513 human PHGDH 26227 O43175 PHGDH human T57 4730705 GLIVRsAtkVtADVI 2-Hacid_dh X X +PRKCZ PKCZ Q05513 human PIAS4 51588 Q8N2W9 PIAS4 human S18 56589715 MVMSFRVsDLQMLLG X +PRKCZ PKCZ Q05513 human NUMB iso3 8650 P49757-3 NUMB human S284 470030 sPFKRQLsLRINELP NumbF X +PRKCZ PKCZ Q05513 human CTNNB1 1499 P35222 CTNNB1 human S45 447488 GATtTAPsLsGkGNP X 9565; 9564; 24710; 70034; 19807; 96727; 77605 +PRKCZ PKCZ Q05513 human AID 11628 Q9WVE0 Aicda mouse S3 20660600 _____MDsLLMKQKK X +PRKCZ PKCZ Q05513 human CACNA1C 100101555 P15381 CACB rabbit S533 453091 RIsKSKFsRYWRRWN X +PRKCZ PKCZ Q05513 human PHGDH 26227 O43175 PHGDH human T78 4730715 QVVGrAGtGVDNVDL 2-Hacid_dh X X +PRKCZ PKCZ Q05513 human SRC-3 8202 Q9Y6Q9 NCOA3 human T1064 4252807 LHtLLsNtDAtGLEE Nuc_rec_co-act X +PRKCZ PKCZ Q05513 human MYH10 4628 P35580 MYH10 human S1935 4730818 LRrGGPIsFsssrSG X +PRKCZ PKCZ Q05513 human p47phox 114553 F1M707 Ncf1 rat S316 451725 AQSIHQRsRKRLsQD NECFESHC X +PRKCZ PKCZ Q05513 human ERK5 23939 Q9WVS8 Mapk7 mouse S486 450251 LKAALLKsLRSRLRD X +PRKCZ PKCZ Q05513 human CASP9 842 P55211 CASP9 human S144 458346 GDVGALEsLRGNADL X X +PRKCZ PKCZ Q05513 human HMGB1 3146 P09429 HMGB1 human S39 7320388 PDAsVNFsEFskkCs HMG_box_2 X +PRKCZ PKCZ Q05513 human Tau iso8 4137 P10636-8 MAPT human S324 449328 kVtskCGsLGNIHHk Tubulin-binding X +PRKCZ PKCZ Q05513 human Snail1 6615 O95863 SNAI1 human S249 1867725600 ARTFsRMsLLHKHQE X X +PRKCZ PKCZ Q05513 human IRS1 25467 P35570 Irs1 rat S498 451680 PGATMGTsPALtGDE X +PRKCZ PKCZ Q05513 human CHAT iso3 1103 P28329-3 CHAT human S440 449057 VPTYESAsIRRFQEG Carn_acyltransf X +PRKCZ PKCZ Q05513 human eNOS 287024 P29473 NOS3 cow T497 447885 AGITRKktFKEVANA X +PRKCZ PKCZ Q05513 human TNNI3 511094 P08057 TNNI3 cow S46 450691 KKSKIsAsRKLQLKT X +PRKCZ PKCZ Q05513 human YAP1 10413 P46937 YAP1 human S109 452305 ksHsRQAstDAGtAG X 46931; 53749 +PRKCZ PKCZ Q05513 human IRAP 171105 P97629 Lnpep rat S91 459010 RSSGLRNsATGYRQS X +PRKCZ PKCZ Q05513 human LKB1 20869 Q9WTK7 Stk11 mouse S431 448147 sNKIRRLsACKQQ__ X 3482 +PRKCZ PKCZ Q05513 human P311 9315 Q16612 NREP human S59 457551 LGSSELRsPRISYLH Alveol-reg_P311 X +PRKCZ PKCZ Q05513 human Tau iso8 4137 P10636-8 MAPT human S293 449327 NVQskCGsKDNIkHV Tubulin-binding X +PRKCZ PKCZ Q05513 human GEM 2669 P55040 GEM human S261 450647 AyQKRKEsMPRKARR X +PRKCZ PKCZ Q05513 human RAGE 177 Q15109 AGER human S391 4731275 ERAELNQsEEPEAGE X X +PRKCZ PKCZ Q05513 human p47phox 653361 P14598 NCF1 human S304 449406 GAPPRRssIRNAHsI NECFESHC X X +PRKCZ PKCZ Q05513 human IRS1 25467 P35570 Irs1 rat S570 451681 RLPGYRHsAFVPTHS X +PRKCZ PKCZ Q05513 human NFkB-p65 5970 Q04206 RELA human S311 449966 RtyEtFksIMkksPF X +PRKCZ PKCZ Q05513 human PARD6A 50855 Q9NPB6 PARD6A human S345 15714600 RGDGSGFsL______ X +PRKCZ PKCZ Q05513 human SRC-3 8202 Q9Y6Q9 NCOA3 human S1062 4252805 DQLHtLLsNtDAtGL Nuc_rec_co-act X +PRKCZ PKCZ Q05513 human CDK5R1 12569 P61809 Cdk5r1 mouse S33 13421403 HYTAVQNsKNAKDKN X X +PRKCZ PKCZ Q05513 human PAR3-alpha 81918 Q9Z340 Pard3 rat S827 467266 REGFGRQsMSEKRtK X +PRKCZ PKCZ Q05513 human IRS1 25467 P35570 Irs1 rat S612 447562 DDGyMPMsPGVAPVP X 3193; 2386; 3203 +PRKCZ PKCZ Q05513 human SRC-3 8202 Q9Y6Q9 NCOA3 human T1059 4252801 ALLDQLHtLLsNtDA Nuc_rec_co-act X +PRKCZ PKCZ Q05513 human MYH10 4628 P35580 MYH10 human S1956 465600 EGAsLELsDDDtEsK X +PRKCZ PKCZ Q05513 human occludin 100506658 Q16625 OCLN human T404 471472 HyEtDyttGGEsCDE X X +PRKCZ PKCZ Q05513 human SRC-3 8202 Q9Y6Q9 NCOA3 human S1033 4252802 NRPLLRNsLDDLVGP X +PRKCZ PKCZ Q05513 human PHGDH 26227 O43175 PHGDH human S55 27457668 CEGLIVRsAtkVtAD 2-Hacid_dh X X +PRKCZ PKCZ Q05513 human Vimentin 7431 P08670 VIM human S34 455454 srsyVttstrtysLG Filament_head X +PRKCZ PKCZ Q05513 human KLF10 7071 Q13118 KLF10 human S384 5263526 GkTYFKssHLkAHTR X +PRKCZ PKCZ Q05513 human Tau iso8 4137 P10636-8 MAPT human S258 487453 PDLkNVKskIGstEN Tubulin-binding X +PRKCZ PKCZ Q05513 human PAK5 57144 Q9P286 PAK5 human S99 29574070 ISVTRSNsLRKESPP X +PRKCZ PKCZ Q05513 human IRS1 25467 P35570 Irs1 rat S318 451399 MVGGkPGsFRVRAss X 5610 +PRKCZ PKCZ Q05513 human GSK3B 2932 P49841 GSK3B human S9 449111 SGRPRttsFAEsCkP X 9336; 9331; 9327; 9323; 9322; 9325; 5558; 8566; 79774; 8466; 25462; 14026; 14332; 14310; 14630 +PRKCZ PKCZ Q05513 human ZO2 403854 Q95168 TJP2 dog S257 28700303 PDARHAGsRsRsREH X +PRKCZ PKCZ Q05513 human MYH10 4628 P35580 MYH10 human S1937 2017900 rGGPIsFsssrSGRR X X +PRKCZ PKCZ Q05513 human PKCZ 18762 Q02956 Prkcz mouse S186 3136104 TCRRHMDsVMPSQEP X +PRKCZ PKCZ Q05513 human P70S6KB 6199 Q9UBS0 RPS6KB2 human S473 450071 PPSGTKKsKRGRGRP X +PRKCZ PKCZ Q05513 human PKCZ 18762 Q02956 Prkcz mouse S113 5250802 PCPGEDKsIYRRGAR X +PRKCZ PKCZ Q05513 human AQP9 366 O43315 AQP9 human S11 477183 EGAEKGKsFKQRLVL X X +PRKCZ PKCZ Q05513 human SP1 6667 P08047 SP1 human T668 452043 SYCGKRFtRsDELQR zf-C2H2 X X +PRKCZ PKCZ Q05513 human BAX 581 Q07812 BAX human S184 451017 VAGVLTAsLtIWKKM TM X X +PRKCZ PKCZ Q05513 human SMARCD3 6604 Q6STE5 SMARCD3 human S247 27422800 VKRPGDLsVRCTLLL X X +PRKCZ PKCZ Q05513 human LKB1 6794 Q15831 STK11 human S428 448147 SSkIRRLsACkQQ__ X X 3482 +PRKCZ PKCZ Q05513 human LC3B 81631 Q9GZQ8 MAP1LC3B human T50 37045604 QLPVLDktkFLVPDH ATG8 X X +PRKCZ PKCZ Q05513 human NR1H4 iso2 9971 Q96RI1-2 NR1H4 human T442 3333402 GRLTELRtFNHHHAE Hormone_recep X +PRKCZ PKCZ Q05513 human occludin 100506658 Q16625 OCLN human T424 19083406 IREYPPItSDQQRQL Occludin_ELL X X +PRKCZ PKCZ Q05513 human CACNA1C 100101555 P15381 CACB rabbit S528 486358 ARLAHRIsKSKFsRY X +PRKCZ PKCZ Q05513 human IRS1 3667 P35568 IRS1 human S323 451399 MVGGKPGsFRVRAss X X 5610 +PRKCZ PKCZ Q05513 human SP1 6667 P08047 SP1 human T681 470069 QRHKRtHtGEkkFAC X X +PRKCZ PKCZ Q05513 human HMGB1 3146 P09429 HMGB1 human S53 25604400 sERWktMsAkEKGkF HMG_box_2 X +PRKCZ PKCZ Q05513 human p47phox 653361 P14598 NCF1 human S315 451725 AHsIHQRsRKRLsQD NECFESHC X +PRKCZ PKCZ Q05513 human ADD2 119 P35612 ADD2 human S713 449802 KKKFRtPsFLKKsKK X +PRKCZ PKCZ Q05513 human ADD1 118 P35611 ADD1 human S726 449829 KKKFRtPsFLKKsKK X +PRKCZ PKCZ Q05513 human SLP-2 30968 Q9UJZ1 STOML2 human S17 20745207 GALLLRGsLLASGRA X X +PRKCZ PKCZ Q05513 human Vimentin 7431 P08670 VIM human S39 451766 ttstrtysLGsALrP Filament_head X 13614 +PRKCZ PKCZ Q05513 human SRC-3 8202 Q9Y6Q9 NCOA3 human T1114 4252804 KAGLYGQtYPAQGPP X +PRKCZ PKCZ Q05513 human p47phox 653361 P14598 NCF1 human S328 449404 QDAYRRNsVRFLQQR NECFESHC X +PRKCZ PKCZ Q05513 human RED1 104 P78563 ADARB1 human S211 23138309 GDLSLSAsPVPAsLA X X +PRKCZ PKCZ Q05513 human NR0B2 8431 Q15466 NR0B2 human T55 28702400 QLCAPHRtCrEALDV Hormone_recep X X +PRKCZ PKCZ Q05513 human CHAT iso3 1103 P28329-3 CHAT human S476 454037 HKAAVPAsEKLLLLK Carn_acyltransf X +PRKCZ PKCZ Q05513 human YAP1 10413 P46937 YAP1 human T110 452306 sHsRQAstDAGtAGA X +PRKCZ PKCZ Q05513 human HMGB1 3146 P09429 HMGB1 human S181 20506700 GVVkAEKsKKKKEEE X +PRKCZ PKCZ Q05513 human PKCZ 18762 Q02956 Prkcz mouse T560 447572 TSEPVQLtPDDEDVI Pkinase_C X +PRKCZ PKCZ Q05513 human HABP4 22927 Q5JVS0 HABP4 human T375 11380903 GRGARGGtRGGRGRI IHABP4_N X +PRKCZ PKCZ Q05513 human IKKB 3551 O14920 IKBKB human S177 447492 AkELDQGsLCtsFVG Pkinase X 2078; 2697; 2694; 14938; 92255; 36516; 36214 +PRKCZ PKCZ Q05513 human BVR 644 P53004 BLVRA human S149 486325 GkDLLkGsLLFTAGP Biliv-reduc_cat X X +PRKCZ PKCZ Q05513 human IRS1 3667 P35568 IRS1 human S441 1990800 SPCDFRSsFRsVtPD X +PRKCZ PKCZ Q05513 human IRAP 171105 P97629 Lnpep rat S80 459009 SAKLLGMsFMNRSSG X +PRKCZ PKCZ Q05513 human KIBRA 23286 Q8IX03 WWC1 human S978 5310901 KRPSsVKsLRSERLI X +PRKCZ PKCZ Q05513 human SRC-3 8202 Q9Y6Q9 NCOA3 human T1067 4252800 LLsNtDAtGLEEIDR Nuc_rec_co-act X +PRKCZ PKCZ Q05513 human SRC-3 8202 Q9Y6Q9 NCOA3 human S1048 4252803 PsNLEGQsDERALLD Nuc_rec_co-act X +PRKCZ PKCZ Q05513 human PTEN 5728 P60484 PTEN human T383 448315 HyRYsDttDsDPENE X 9554; 9549; 7960 +PRKCZ PKCZ Q05513 human occludin 100506658 Q16625 OCLN human T403 471471 DHyEtDyttGGEsCD X X +PRKCZ PKCZ Q05513 human IRS1 25467 P35570 Irs1 rat S307 447558 TEsITATsPASMVGG X 2381 +PRKCZ PKCZ Q05513 human SP1 6667 P08047 SP1 human S670 2255401 CGKRFtRsDELQRHK zf-C2H2 X X +PRKCZ PKCZ Q05513 human IKKB 3551 O14920 IKBKB human S181 447489 DQGsLCtsFVGTLQy Pkinase X 2697; 2694; 14938; 92255; 36516; 36214 +PRKCZ PKCZ Q05513 human KIBRA 23286 Q8IX03 WWC1 human S975 5310900 VRMKRPSsVKsLRSE X +PRKCZ PKCZ Q05513 human KLF10 7071 Q13118 KLF10 human T445 20573500 FMRSDHLtkHARRHL zf-C2H2 X +PRKCZ PKCZ Q05513 human SP1 6667 P08047 SP1 human S641 470040 GKVYGKtsHLRAHLR zf-C2H2 X X +PRKCZ PKCZ Q05513 human HABP4 22927 Q5JVS0 HABP4 human T354 11380902 RKPANDItSQLEINF IHABP4_N X +PRKCZ PKCZ Q05513 human CACNA1C 100101555 P15381 CACB rabbit S1674 480102 QGLVGKPsQRNALSL X +PRKCZ PKCZ Q05513 human LKB1 6794 Q15831 STK11 human S307 7710000 IRQIRQHsWFRkKHP Pkinase X X +PRKCZ PKCZ Q05513 human PFKFB2 287019 P26285 PFKFB2 cow T476 465673 TPLSSSNtIRRPRNY X +PRKCZ PKCZ Q05513 human JAM-A 16456 O88792 F11r mouse S285 467829 kVIysQPstRsEGEF X X +PRKCZ PKCZ Q05513 human PTEN 5728 P60484 PTEN human T382 448314 DHyRYsDttDsDPEN X 9554; 9549; 7960 +PRKCZ PKCZ Q05513 human IRS1 25467 P35570 Irs1 rat S24 455604 GYLRKPKsMHKRFFV PH X +PRKCZ PKCZ Q05513 human TRAF2 7186 Q12933 TRAF2 human S55 7378202 QCGHRYCsFCLASIL zf-C3HC4 X X +PRKCZ PKCZ Q05513 human NRF2 4780 Q16236 NFE2L2 human S40 450082 SREVFDFsQRRkEYE X +PRKCZ PKCZ Q05513 human NUMB iso3 8650 P49757-3 NUMB human S265 456490 EQLARQGsFRGFPAL NumbF X 4140; 9878 +PRKCZ PKCZ Q05513 human RED1 104 P78563 ADARB1 human S216 1040254700 SAsPVPAsLAQPPLP X X +PRKCZ PKCZ Q05513 human NUMB 18222 Q9QZS3 Numb mouse S295 470030 sPFKRQLsLRINELP NumbF X +PRKCZ PKCZ Q05513 human SP1 6667 P08047 SP1 human S702 5262508 FMRsDHLskHIKtHQ zf-C2H2 X +PRKCZ PKCZ Q05513 human Vimentin 7431 P08670 VIM human S56 451514 srsLyAssPGGVyAt Filament_head X 3877; 7391 + PKCE no information TRPV1 83810 O35433 Trpv1 rat T704 487542 WKLQRAItILDTEKS X + PKCE no information ZO2 403854 Q95168 TJP2 dog S369 9730701 QLVVLRDsKQTLINI X + PKCE no information TRPV1 83810 O35433 Trpv1 rat S502 450016 YFLQRRPsLKSLFVD Ion_trans X +WEE1 Wee1 P30291 human CDK1 54237 P39951 Cdk1 rat Y15 447610 EKIGEGtyGVVyKGR Pkinase X 4539; 9111; 14566; 77897 +WEE1 Wee1 P30291 human HSP90A 3320 P07900 HSP90AA1 human Y38 15229603 SLIINtFySNkEIFL X +WEE1 Wee1 P30291 human CDK2 1017 P24941 CDK2 human Y15 447740 EkIGEGtyGVVykAR Pkinase X +WEE1 Wee1 P30291 human CDK1 12534 P11440 Cdk1 mouse Y15 447610 EKIGEGtyGVVyKGR Pkinase X 4539; 9111; 14566; 77897 +WEE1 Wee1 P30291 human CDK1 983 P06493 CDK1 human Y15 447610 EkIGEGtyGVVykGR Pkinase X X 4539; 9111; 14566; 77897 +WEE1 Wee1 P30291 human ERG 2078 P11308 ERG human Y183 1870421702 FQRLtPSyNADILLS SAM_PNT X X +PLK3 PLK3 Q9H4B4 human ATF-2 1386 P15336 ATF2 human T69 448224 sVIVADQtPtPtRFL X 9225; 94125; 40749; 61584; 44167 +PLK3 PLK3 Q9H4B4 human 14-3-3 epsilon 7531 P62258 YWHAE human T208 14569209 DAIAELDtLsEEsyk 14-3-3 X +PLK3 PLK3 Q9H4B4 human ATF-2 1386 P15336 ATF2 human T71 448225 IVADQtPtPtRFLkN X 9225; 9221; 5112; 94125; 13850; 40749; 15411; 24329; 61584; 27934; 92109; 20534; 35858 +PLK3 PLK3 Q9H4B4 human TOP2A 7153 P11388 TOP2A human T1343 448763 FsDFDEKtDDEDFVP X X +PLK3 PLK3 Q9H4B4 human CALU 813 O43852 CALU human S44 4274908 kVHNDAQsFDyDHDA X +PLK3 PLK3 Q9H4B4 human Chk2 11200 O96017 CHEK2 human S62 3793200 sSSGTLSsLEtVstQ X +PLK3 PLK3 Q9H4B4 human HSP90B 3326 P08238 HSP90AB1 human S718 3177650 LEGDEDAsRMEEVD_ X +PLK3 PLK3 Q9H4B4 human NFL 18039 P08551 Nefl mouse S473 450895 EAKDEPPsEGEAEEE X +PLK3 PLK3 Q9H4B4 human CALU 813 O43852 CALU human T254 25688703 GkMDKEEtkDWILPs X +PLK3 PLK3 Q9H4B4 human CALU 813 O43852 CALU human T60 25688700 LGAEEAktFDQLtPE X +PLK3 PLK3 Q9H4B4 human PTEN 5728 P60484 PTEN human S370 448649 TSVtPDVsDNEPDHy X +PLK3 PLK3 Q9H4B4 human CDC25C 995 P30307 CDC25C human S191 450979 EDQAEEIsDELMEFs M-inducer_phosp X +PLK3 PLK3 Q9H4B4 human SNCB 6620 Q16143 SNCB human S118 448525 LMEPEGEsYEDPPQE Synuclein X X +PLK3 PLK3 Q9H4B4 human Bcl-xL 598 Q07817 BCL2L1 human S49 21336504 ESEMEtPsAINGNPS X X +PLK3 PLK3 Q9H4B4 human SNCA 6622 P37840 SNCA human S129 448278 NEAyEMPsEEGyQDy Synuclein X X 23706; 87281 +PLK3 PLK3 Q9H4B4 human HIF1A 3091 Q16665 HIF1A human S657 17331802 EttsATssPYRDTQS X X +PLK3 PLK3 Q9H4B4 human SNCA 20617 O55042 Snca mouse S129 448278 SEAyEMPsEEGYQDY Synuclein X 23706; 87281 +PLK3 PLK3 Q9H4B4 human Chk2 11200 O96017 CHEK2 human S73 2251701 VstQELYsIPEDQEP X +PLK3 PLK3 Q9H4B4 human PTEN 5728 P60484 PTEN human T366 449634 ASSsTSVtPDVsDNE X +PLK3 PLK3 Q9H4B4 human CALU 813 O43852 CALU human T196 25688702 KDIVVQEtMEDIDKN EF-hand_5 X +PLK3 PLK3 Q9H4B4 human NPM1 4869 P06748 NPM1 human S4 452023 ____MEDsMDMDMsP X 3520 +PLK3 PLK3 Q9H4B4 human CDC25C 995 P30307 CDC25C human S198 448636 sDELMEFsLKDQEAK M-inducer_phosp X 9529 +PLK3 PLK3 Q9H4B4 human Jun 3725 P05412 JUN human S73 447943 VGLLkLAsPELERLI Jun X 9164; 3270; 8752; 12714; 77955 +PLK3 PLK3 Q9H4B4 human p53 7157 P04637 TP53 human S20 447529 PLsQEtFsDLWkLLP P53_TAD X X 9287 +PLK3 PLK3 Q9H4B4 human CCNB1 891 P14635 CCNB1 human S133 448445 sPsPMETsGCAPAEE X 4133 +PLK3 PLK3 Q9H4B4 human Jun 3725 P05412 JUN human S63 447686 kNsDLLtsPDVGLLk Jun X 5464; 9261; 2361; 97721; 91952 +PLK3 PLK3 Q9H4B4 human CASP8 841 Q14790 CASP8 human T273 56640300 DAGALTTtFEELHFE Peptidase_C14 X X +PLK3 PLK3 Q9H4B4 human VRK1 7443 Q99986 VRK1 human S342 5938010 DDGkLDLsVVENGGL X X +PLK3 PLK3 Q9H4B4 human CDC25A 993 P30304 CDC25A human T80 4209300 RMGssEstDsGFCLD X X +PLK3 PLK3 Q9H4B4 human occludin 100506658 Q16625 OCLN human S471 6094301 LDDyREEsEEyMAAA Occludin_ELL X +PLK3 PLK3 Q9H4B4 human HIF1A 3091 Q16665 HIF1A human S576 17331801 DDDFQLRsFDQLSPL HIF-1 X X +PLK3 PLK3 Q9H4B4 human CALU 813 O43852 CALU human T177 25688701 IATkEEFtAFLHPEE X +CDK13 CDK13 Q14004 human SERINC5 256987 Q86VE9 SERINC5 human S360 1874340202 ARCCFCFsPGGEDTE Serinc X X +CDK13 CDK13 Q14004 human 4E-BP1 1978 Q13541 EIF4EBP1 human S65 447527 FLMECrNsPVtktPP eIF_4EBP X 9451; 9456; 13443 +CDK13 CDK13 Q14004 human EIF4B 1975 P23588 EIF4B human S406 470374 RPRERHPsWRsEEtQ X X 8151; 5399 +CDK13 CDK13 Q14004 human POLR2A 5430 P24928 POLR2A human S1616 450204 TPQSPSysPtsPsYS RNA_pol_Rpb1_R X 4735; 13499; 13546; 31262 +CDK13 CDK13 Q14004 human 4E-BP1 1978 Q13541 EIF4EBP1 human T70 447528 rNsPVtktPPRDLPt eIF_4EBP X 9455; 13396 +CDK13 CDK13 Q14004 human POLR2A 5430 P24928 POLR2A human S1619 447616 SPSysPtsPsYSPTS RNA_pol_Rpb1_R X 4735; 13523; 13546; 67221 +CDK13 CDK13 Q14004 human 4E-BP1 1978 Q13541 EIF4EBP1 human T46 447496 GGtLFsttPGGtRII eIF_4EBP X X 2855; 9459; 2846; 4923; 5123; 3929; 7547; 45613; 39788 +CDK13 CDK13 Q14004 human EIF4B 1975 P23588 EIF4B human S422 451290 RERsRtGsEssQtGt X 3591 +MAPK10 JNK3 P53779 human APP iso4 351 P05067-4 APP human T668 448523 VEVDAAVtPEERHLs APP_amyloid X X +MAPK10 JNK3 P53779 human DRPLA 1822 P54259 ATN1 human S739 450317 EEyETPEsPVPPARs Atrophin-1 X +MAPK10 JNK3 P53779 human GR 24413 P06536 Nr3c1 rat S246 451796 LIDENLLsPLAGEDD GCR X 97285 +MAPK10 JNK3 P53779 human BID 637 P55957 BID human T59 448406 EGyDELQtDGNRsSH BID X +MAPK10 JNK3 P53779 human Myc 4609 P01106 MYC human T73 448496 kkFELLPtPPLsPsR Myc_N X 46650 +MAPK10 JNK3 P53779 human OSBP2 23762 Q969R2 OSBP2 human S762 11171320 ECSKVMHssPssPsS Oxysterol_BP X +MAPK10 JNK3 P53779 human p21Cip1 1026 P38936 CDKN1A human S98 478193 GGRRPGTsPALLQGT X +MAPK10 JNK3 P53779 human OSBP2 23762 Q969R2 OSBP2 human S766 15721694 VMHssPssPsSDGKQ Oxysterol_BP X +MAPK10 JNK3 P53779 human BIM 12125 O54918 Bcl2l11 mouse S65 449330 GPLAPPAsPGPFATR X 4581; 4585 +MAPK10 JNK3 P53779 human Myc 4609 P01106 MYC human S86 449991 sRRsGLCsPSyVAVt Myc_N X +MAPK10 JNK3 P53779 human p21Cip1 1026 P38936 CDKN1A human S130 455618 sGEQAEGsPGGPGDs X +MAPK10 JNK3 P53779 human CBX7 52609 Q8VDS3 Cbx7 mouse T119 29669800 TNGPPPWtPTLPSSE CBX7_C X +MAPK10 JNK3 P53779 human STMN1 16765 P54227 Stmn1 mouse S38 448556 sVPdFPLsPPKKKDL Stathmin X 3426; 4191 +MAPK10 JNK3 P53779 human MCL1 17210 P97287 Mcl1 mouse S102 1172400 SAAAAIVsPEEELDG X +MAPK10 JNK3 P53779 human MCL1 17210 P97287 Mcl1 mouse T144 455375 ADGsLPStPPPPEEE X 4579 +MAPK10 JNK3 P53779 human SHC1 20416 P98083 Shc1 mouse S36 448508 TPPEELPsPSASSLG X +MAPK10 JNK3 P53779 human OSBP2 23762 Q969R2 OSBP2 human S768 15721697 HssPssPsSDGKQKT Oxysterol_BP X +MAPK10 JNK3 P53779 human Myc 4609 P01106 MYC human S77 448586 LLPtPPLsPsRRsGL Myc_N X 13748 +MAPK10 JNK3 P53779 human KIF5C 16574 P28738 Kif5c mouse S176 54436200 CTERFVSsPEEVMDV Kinesin X +MAPK10 JNK3 P53779 human STMN1 16765 P54227 Stmn1 mouse S25 448555 QAFELILsPRskEsV Stathmin X +MAPK10 JNK3 P53779 human NFAT2 4772 O95644 NFATC1 human S172 465577 YRDPsCLsPASSLSS X +MAPK10 JNK3 P53779 human OSBP2 23762 Q969R2 OSBP2 human S763 31727226 CSKVMHssPssPsSD Oxysterol_BP X +MAPK10 JNK3 P53779 human KIF5B 16573 Q61768 Kif5b mouse S175 29603400 CTERFVCsPDEVMDT Kinesin X +MAPK10 JNK3 P53779 human APLP2 334 Q06481 APLP2 human T736 451599 VEVDPMLtPEERHLN APP_amyloid X +NEK1 NEK1 Q96PY6 human TAZ 97064 Q9EPK5 Wwtr1 mouse S309 6145195 sREQSTDsGLGLGCy X X +NEK1 NEK1 Q96PY6 human ME1 4199 P48163 ME1 human S336 4701731 KKIWLVDskGLIVKG Malic_M X +NEK1 NEK1 Q96PY6 human VHL 7428 P40337 VHL human T105 23072361 YPtLPPGtGRRIHsy VHL X +NEK1 NEK1 Q96PY6 human RAD54L 8438 Q92698 RAD54L human S572 56589700 PDFVFMLsSKAGGCG Helicase_C X X +NEK1 NEK1 Q96PY6 human VHL 7428 P40337 VHL human T202 27434503 QkDLERLtQERIAHQ VHL_C X +NEK1 NEK1 Q96PY6 human VHL 7428 P40337 VHL human Y112 27434505 tGRRIHsyRGHLWLF VHL X +NEK1 NEK1 Q96PY6 human VHL 7428 P40337 VHL human S183 15227904 RRLDIVRsLyEDLED VHL_C X +NEK1 NEK1 Q96PY6 human VDAC1 7416 P21796 VDAC1 human S193 6406004 DGtEFGGsIyQkVNK Porin_3; TM X X +NEK1 NEK1 Q96PY6 human VHL 7428 P40337 VHL human Y175 27434504 sLVkPENyRRLDIVR VHL_C X +NEK1 NEK1 Q96PY6 human VHL 7428 P40337 VHL human S168 27434501 RCLQVVRsLVkPENy VHL_C X +NEK1 NEK1 Q96PY6 human VHL 7428 P40337 VHL human T100 27434502 GEPQPYPtLPPGtGR VHL X +NEK1 NEK1 Q96PY6 human HEC1 10403 O14777 NDC80 human S165 449867 LGYPFALsKSSMYTV Ndc80_HEC X +JMJD6 JMJD6 Q6NYC1 human H2AX 3014 P16104 H2AX human Y39 462307 RLLRkGHyAERVGAG Histone X X +CDK20 CDK20 Q8IZL9 human ICK 22858 Q9UPZ9 CILK1 human T157 456051 IRSKPPytDyVSTRW Pkinase X X +CDK20 CDK20 Q8IZL9 human CDK2 1017 P24941 CDK2 human T160 447739 GVPVRtytHEVVtLW Pkinase X X 2561 +Mapk3 ERK1 P21708 rat STMN2 84510 P21818 Stmn2 rat S62 450174 ELILKPPsPISEAPR Stathmin X +Mapk3 ERK1 P21708 rat p90RSK 6195 Q15418 RPS6KA1 human T573 447993 AENGLLMtPCytANF Pkinase X 9346 +Mapk3 ERK1 P21708 rat GJA1 24392 P08050 Gja1 rat S282 448854 TAPLsPMsPPGYkLV X X +Mapk3 ERK1 P21708 rat NSMF 117536 Q9EPI6 Nsmf rat S180 27713502 AKLVPGPsPRAFGLE X +Mapk3 ERK1 P21708 rat HSL 25330 P15304 Lipe rat S900 450193 GNSEPSDsPEMSQsM X +Mapk3 ERK1 P21708 rat ATP1A1 24211 P06685 Atp1a1 rat S16 449086 KyEPAAVsEHGDkks X X 4020 +Mapk3 ERK1 P21708 rat MAP2 iso2 25595 P15146-2 Map2 rat S136 448323 ETVNLPPsPPPSPAS X 4541 +Mapk3 ERK1 P21708 rat TRPV2 29465 Q9WUD2 Trpv2 rat S6 29631548 __MTSASsPPAFRLE X +Mapk3 ERK1 P21708 rat TRPV2 29465 Q9WUD2 Trpv2 rat S47 12738661 QREDRNSsPQIKVNL X +Mapk3 ERK1 P21708 rat NuMA-1 308870 F1LW91 Numa1 rat S1723 453119 SVPGEPAsPIsQRLP X +Mapk3 ERK1 P21708 rat HMG20A 315689 D3Z937 Hmg20a rat S105 469654 RDSNAPKsPLTGYVR HMG_box X +Mapk3 ERK1 P21708 rat AML1 861 Q01196 RUNX1 human S266 454400 QYLGsIAsPsVHPAt X X +Mapk3 ERK1 P21708 rat JunB 24517 P24898 Junb rat S256 452631 RDAtPPVsPINMEDQ X +Mapk3 ERK1 P21708 rat Fos 314322 P12841 Fos rat T331 448484 CtPVVTCtPSCTTYT X +Mapk3 ERK1 P21708 rat SYN1 24949 P09951 Syn1 rat S62 451572 stAAPVAsPAAPsPG X +Mapk3 ERK1 P21708 rat CAD 101843763 P08955 Cad hamster T456 451248 KVYFLPItPHYVTQV X +Mapk3 ERK1 P21708 rat ELK1 314436 A4GTP4 Elk1 rat S382 447872 IHFWSTLsPIAPRSP X +Mapk3 ERK1 P21708 rat DUSP6 116663 Q64346 Dusp6 rat S197 455266 SATDSDGsPLSNSQP X +Mapk3 ERK1 P21708 rat SYN1 24949 P09951 Syn1 rat S549 451574 PAARPPAsPsPQRQA X +Mapk3 ERK1 P21708 rat LIFR 3977 P42702 LIFR human S1044 450385 WNLVsPDsPRsIDSN X +Mapk3 ERK1 P21708 rat PTP-SL iso2 19279 Q62132-2 Ptprr mouse T253 450119 EPFVAVStPREKVAM X +Mapk3 ERK1 P21708 rat MAP2 25595 P15146 Map2 rat S136 448323 ETVNLPPsPPPsPAS X 4541 +Mapk3 ERK1 P21708 rat Fos 314322 P12841 Fos rat S374 448482 PSSDSLSsPTLLAL_ X +Mapk3 ERK1 P21708 rat GJA1 24392 P08050 Gja1 rat S279 448853 SSPTAPLsPMsPPGY X X +Mapk3 ERK1 P21708 rat SP1 6667 P08047 SP1 human T739 448227 sEGSGtAtPSALITT X +Mapk3 ERK1 P21708 rat ENaC-gamma 24768 P37091 Scnn1g rat T623 451220 PGSTVPGtPPPRYNT X +Mapk3 ERK1 P21708 rat SYN1 24949 P09951 Syn1 rat S67 451573 VAsPAAPsPGSSGGG X +Mapk3 ERK1 P21708 rat UBF 25574 P25977 Ubtf rat T117 448504 DFPKKPLtPYFRFFM HMG_box X X +Mapk3 ERK1 P21708 rat ERK1 50689 P21708 Mapk3 rat T208 3949243 FLtEyVAtRWYRAPE Pkinase X X +Mapk3 ERK1 P21708 rat Bcl-2 24224 P49950 Bcl2 rat S70 448395 RDTAARTsPLRPLVA X +Mapk3 ERK1 P21708 rat TRPV2 29465 Q9WUD2 Trpv2 rat S37 8110156 QEPPPMEsPFQREDR X +Mapk3 ERK1 P21708 rat AML1 861 Q01196 RUNX1 human S249 454399 DTRQIQPsPPWsyDQ X X 4327 +Mapk3 ERK1 P21708 rat GJA1 24392 P08050 Gja1 rat S255 448852 HATTGPLsPskDCGs X +Mapk3 ERK1 P21708 rat SMAD3 4088 P84022 SMAD3 human S208 451179 DAGsPNLsPNPMsPA X +Mapk3 ERK1 P21708 rat ENaC-beta 24767 P37090 Scnn1b rat T613 451219 QTLPIPGtPPPNYDS X +Mapk3 ERK1 P21708 rat STMN2 84510 P21818 Stmn2 rat S73 450173 EAPRTLAsPKKkDLs Stathmin X +Mapk3 ERK1 P21708 rat DDX47 297685 G3V727 Ddx47 rat S9 9765795 AADEEPDsPtEALQT X +Mapk3 ERK1 P21708 rat JunD 24518 P52909 Jund rat S100 456168 LGLLKLAsPELERLI Jun X 9164 +Mapk3 ERK1 P21708 rat gephyrin 64845 Q03555 Gphn rat S281 483463 AsLSttPsEsPRAQA X +Mapk3 ERK1 P21708 rat Caldesmon 25687 Q62736 Cald1 rat S527 448466 QSVDKVTsPTKV___ X +Mapk3 ERK1 P21708 rat ZO1 292994 A0A0G2K2P5 Tjp1 rat S402 28100900 PDVDLPVsPSDGVLP X +Mapk3 ERK1 P21708 rat Myc 4609 P01106 MYC human S77 448586 LLPtPPLsPsRRsGL Myc_N X 13748 +Mapk3 ERK1 P21708 rat MAP2 iso3 25595 P15146-3 Map2 rat S136 448323 ETVNLPPsPPPSPAS X 4541 +Mapk3 ERK1 P21708 rat MAP2 25595 P15146 Map2 rat T1622 450181 YSSRtPGtPGtPSyP X 4544 +Mapk3 ERK1 P21708 rat SP1 6667 P08047 SP1 human T453 448226 SGPIIIRtPTVGPNG X +Mapk3 ERK1 P21708 rat EFNB3 360546 G3V7D4-1 Efnb3 rat S332 27722391 VQDGPPQsPPNIYYK X +Mapk3 ERK1 P21708 rat TRPV2 29465 Q9WUD2 Trpv2 rat S760 7103644 LPLQVLQsP______ X +Mapk3 ERK1 P21708 rat MEK2 58960 P36506 Map2k2 rat S295 3822601 DGEPHSVsPRPRPPG Pkinase X +Mapk3 ERK1 P21708 rat UBF 25574 P25977 Ubtf rat T201 448505 DIPEKPKtPQQLWYT HMG_box X X +Mapk3 ERK1 P21708 rat TH 25085 P04177 Th rat S31 448544 KQAEAVtsPRFIGRR TOH_N X X 3370; 13041 +Mapk3 ERK1 P21708 rat GRASP65 56082 O35254 Gorasp1 rat S277 455582 EQLPGPGsPGHGTAD X +Mapk3 ERK1 P21708 rat MAP2 25595 P15146 Map2 rat T1625 450182 RtPGtPGtPSyPRTP X 4544 +Mapk3 ERK1 P21708 rat Jun 24516 P17325 Jun rat S246 450451 PGETPPLsPIDMESQ X 2994 +Mknk1 Mnk1 O08605 mouse EIF4E 13684 P63073 Eif4e mouse S209 447776 DTATKSGsttKNRFV X 9741 +Mknk1 Mnk1 O08605 mouse PLA2G4A 18783 P47713 Pla2g4a mouse S726 447599 RQNPsRCsVsLsNVE X X +Mknk1 Mnk1 O08605 mouse EIF4E 1977 P06730 EIF4E human S209 447776 DtATksGsttKNRFV X X 9741 +CSNK1G3 CK1G3 Q9Y6M4 human SNCA 6622 P37840 SNCA human T64 1876998407 EktkEQVtNVGGAVV Synuclein X +CSNK1G3 CK1G3 Q9Y6M4 human LRP6 4040 O75581 LRP6 human T1479 457635 SSsstKGtyFPAILN X +CSNK1G3 CK1G3 Q9Y6M4 human SNCA 20617 O55042 Snca mouse T64 1876998407 EKtKEQVtNVGGAVV Synuclein X +CSNK1G3 CK1G3 Q9Y6M4 human LRP6 4040 O75581 LRP6 human S1490 456289 AILNPPPsPAtERsH X 2568 +CSNK1G3 CK1G3 Q9Y6M4 human LYN 4067 P07948 LYN human S13 1983291 SKGkDsLsDDGVDLk X +Camk1 CAMK1A Q63450 rat NUMB 8650 P49757 NUMB human S276 456490 EQLARQGsFrGFPAL NumbF X X 4140; 9878 +Camk1 CAMK1A Q63450 rat SYN1 24949 P09951 Syn1 rat S9 448378 NYLRRRLsDSNFMAN Synapsin_N X 2311; 67605 +Camk1 CAMK1A Q63450 rat CREB iso1 81646 P15337-1 Creb1 rat S133 448228 EILsRRPsYRkILND pKID X 9187; 9196; 9198; 4095; 14228; 14001; 39561; 80120; 44864; 54960; 95995 +Camk1 CAMK1A Q63450 rat nNOS 24598 P29476 Nos1 rat S741 452159 LAEAVkFsAkLMGQA X X +Camk1 CAMK1A Q63450 rat K18 3875 P05783 KRT18 human S53 447734 IsVsrstsFrGGMGs X +Camk1 CAMK1A Q63450 rat MRLC1 10398 P24844 MYL9 human S20 1863500 KRPQRAtsNVFAMFD X 3674; 3671; 3675; 95777 +Camk1 CAMK1A Q63450 rat HMGCR 25675 P51639 Hmgcr rat S871 448568 SHMVHNRsKINLQDL X +Camk1 CAMK1A Q63450 rat CAMKK1 60341 P97756 Camkk1 rat T108 452083 PRAWRRPtIESHHVA X +Camk1 CAMK1A Q63450 rat SYN1 281510 P17599 SYN1 cow S9 448378 NYLRRRLsDSNFMAN Synapsin_N X +Camk1 CAMK1A Q63450 rat NUMBL 292732 A1L1I3 Numbl rat S305 456489 EQLVRQGsFRGFPAL NumbF X X +Prkch PKCH P23298 mouse PRKD1 18760 Q62101 Prkd1 mouse S744 448589 ARIIGEksFRRsVVG Pkinase X 2054 +Prkch PKCH P23298 mouse PRKD1 85421 Q9WTQ1 Prkd1 rat S748 448590 GEKsFRRsVVGTPAY Pkinase X +Prkch PKCH P23298 mouse PRKD1 18760 Q62101 Prkd1 mouse S748 448590 GEksFRRsVVGtPAy Pkinase X 2054 +Prkch PKCH P23298 mouse PRKD1 85421 Q9WTQ1 Prkd1 rat S744 448589 ARIIGEKsFRRsVVG Pkinase X +AXL AXL P30530 human MLKL 197259 Q8NB16 MLKL human Y376 1868624704 DRVkstAyLSPQELE PK_Tyr_Ser-Thr X +AXL AXL P30530 human ELMO2 63916 Q96JJ3 ELMO2 human Y713 477009 IPKEPssyDFVyHyG X +AXL AXL P30530 human Akt1 207 P31749 AKT1 human S473 447855 RPHFPQFsysAsGtA Pkinase_C X 9271; 3787; 4060; 4051; 5102; 4058; 2336; 2337; 4075; 4070; 5012; 4071; 92982; 5315; 9563; 9018; 12694; 52240; 11962; 15116; 88106; 26580; 68035; 31957; 23430; 20235 +AXL AXL P30530 human STAT5A 6776 P42229 STAT5A human Y694 447767 LAkAVDGyVkPQIkQ X 9365; 9356; 9359; 9351; 4322; 9314; 3939; 40284; 5387; 14603; 66740; 51879; 72712 +AXL AXL P30530 human ELMO1 9844 Q92556 ELMO1 human Y724 455566 PsNyDFVyDCN____ X +AXL AXL P30530 human STAT3 6774 P40763 STAT3 human Y705 448192 DPGsAAPyLktKFIC X 4093; 9145; 4324; 9131; 9138; 4323; 4074; 4113; 48313; 20977; 25023; 8119; 52075; 52527; 73533; 61958; 73452; 16185; 74309 +AXL AXL P30530 human Lck 3932 P06239 LCK human Y394 447822 RLIEDNEytAREGAk PK_Tyr_Ser-Thr X 2101; 6943; 59548; 70926; 78740; 94361; 17320 +AXL AXL P30530 human Fyn 2534 P06241 FYN human Y420 447882 RLIEDNEytARQGAk PK_Tyr_Ser-Thr X 2101; 6943; 59548; 70926; 78740; 94361; 17320 +AXL AXL P30530 human ELMO1 9844 Q92556 ELMO1 human Y720 455565 IPKEPsNyDFVyDCN X X +AXL AXL P30530 human LYN 4067 P07948 LYN human Y397 448695 RVIEDNEytAREGAk PK_Tyr_Ser-Thr X 2101; 6943; 59548; 70926; 78740; 94361; 17320 +AXL AXL P30530 human Hck 3055 P08631 HCK human Y411 448168 RVIEDNEytAREGAk PK_Tyr_Ser-Thr X 2101; 6943; 59548; 70926; 78740; 94361; 17320 +AXL AXL P30530 human STAT5B 6777 P51692 STAT5B human Y699 448198 tAkAVDGyVkPQIkQ X 9365; 9356; 9359; 9351; 4322; 9314; 3939; 40284; 5387; 14603; 66740; 51879; 72712 +AXL AXL P30530 human Src 6714 P12931 SRC human Y419 448234 RLIEDNEytARQGAk PK_Tyr_Ser-Thr X 2101; 6943; 59548; 70926; 78740; 94361; 17320 +AXL AXL P30530 human Yes 7525 P07947 YES1 human Y426 447619 RLIEDNEytARQGAk PK_Tyr_Ser-Thr X 2101; 6943; 59548; 70926; 78740; 94361; 17320 +AXL AXL P30530 human Akt1 207 P31749 AKT1 human T308 447856 kDGAtMKtFCGtPEy Pkinase X 5106; 2965; 9275; 4056; 5056; 13842; 13038; 43506; 48646; 86758; 80722; 77440; 80556 +Plk2 PLK2 P53351 mouse SNCA 6622 P37840 SNCA human S129 448278 NEAyEMPsEEGyQDy Synuclein X 23706; 87281 +Plk2 PLK2 P53351 mouse SNCA 20617 O55042 Snca mouse S129 448278 SEAyEMPsEEGYQDY Synuclein X 23706; 87281 +Fgfr2 FGFR2 P21803 mouse PLCG1 18803 Q62077 Plcg1 mouse Y771 448575 IGTAEPDyGALyEGR X +DAPK3 DAPK3 O43293 human PPP1R14A 94274 Q96A00 PPP1R14A human S12 10294800 rLGKRVLsKLQsPSr PP1_inhibitor X +DAPK3 DAPK3 O43293 human DAPK3 1613 O43293 DAPK3 human T306 454894 tTRLkEytIksHssL X +DAPK3 DAPK3 O43293 human DAPK3 1613 O43293 DAPK3 human S311 454895 EytIksHssLPPNNS X +DAPK3 DAPK3 O43293 human MRLC1 296313 Q64122 Myl9 rat S20 1863500 KRPQSAtsNVFAMFD X 3674; 3671; 3675; 95777 +DAPK3 DAPK3 O43293 human LMO7 iso3 4008 Q8WWI1-3 LMO7 human S863 478135 LKNLKRRsQFFEQGS X X +DAPK3 DAPK3 O43293 human MRLC1 10398 P24844 MYL9 human T19 1863501 KKRPQRAtsNVFAMF X 3674; 95777 +DAPK3 DAPK3 O43293 human PPP1R14A 94274 Q96A00 PPP1R14A human T38 449098 QkRHARVtVkYDRRE PP1_inhibitor X +DAPK3 DAPK3 O43293 human MDM2 4193 Q00987 MDM2 human S186 448131 RQRkRHksDsIsLsF X +DAPK3 DAPK3 O43293 human MRLC1 296313 Q64122 Myl9 rat T19 1863501 KKRPQSAtsNVFAMF X 3674; 95777 +DAPK3 DAPK3 O43293 human p21Cip1 1026 P38936 CDKN1A human T145 447837 QGRkRRQtsMTDFyH X X +DAPK3 DAPK3 O43293 human beclin 1 8678 Q14457 BECN1 human S90 472001 IPPARMMstEsANsF X X 29362; 86455 +DAPK3 DAPK3 O43293 human TRIP12 9320 Q14669 TRIP12 human S312 452826 STKkRsEsPPAELPs X +DAPK3 DAPK3 O43293 human MYPT1 396020 Q90623 PPP1R12A chicken T695 448587 ARQSRRstQGVTLTD X X 5163 +DAPK3 DAPK3 O43293 human MDM2 4193 Q00987 MDM2 human S166 448130 SsRRRAIsEtEENsD X 3521 +DAPK3 DAPK3 O43293 human RPL13A 23521 P40429 RPL13A human S77 5594501 PYHFrAPsRIFWRTV Ribosomal_L13 X X +DAPK3 DAPK3 O43293 human MRLC2 103910 O14950 MYL12B human S20 448595 KRPQRAtsNVFAMFD X X +DAPK3 DAPK3 O43293 human p53 7157 P04637 TP53 human S20 447529 PLsQEtFsDLWkLLP P53_TAD X 9287 +DAPK3 DAPK3 O43293 human DAPK3 1613 O43293 DAPK3 human T180 454890 EFKNIFGtPEFVAPE Pkinase X +DAPK3 DAPK3 O43293 human MRLC1 10398 P24844 MYL9 human S20 1863500 KRPQRAtsNVFAMFD X 3674; 3671; 3675; 95777 +DAPK3 DAPK3 O43293 human MRLC1 98932 Q9CQ19 Myl9 mouse S20 1863500 KRPQRAtsNVFAMFD X X 3674; 3671; 3675; 95777 +DAPK3 DAPK3 O43293 human MRLC1 98932 Q9CQ19 Myl9 mouse T19 1863501 KKRPQRAtsNVFAMF X X 3674; 95777 +DAPK3 DAPK3 O43293 human DAPK3 1613 O43293 DAPK3 human T225 454891 LGETKQEtLTNISAV Pkinase X +DAPK3 DAPK3 O43293 human MYPT1 396020 Q90623 PPP1R12A chicken S849 451999 RPREKRRstGVSFWT X +DAPK3 DAPK3 O43293 human DAPK3 1613 O43293 DAPK3 human T265 454892 KDPKRRMtIAQSLEH Pkinase X +DAPK3 DAPK3 O43293 human MRLC2 103910 O14950 MYL12B human T19 448596 KKRPQRAtsNVFAMF X X +DAPK3 DAPK3 O43293 human CDC14A 8556 Q9UNH5 CDC14A human S484 31085757 INSRLASsLGNLNAA X +DAPK3 DAPK3 O43293 human DAPK3 1613 O43293 DAPK3 human T299 454893 PERRRLKtTRLkEyt X +DAPK3 DAPK3 O43293 human MYPT1 396020 Q90623 PPP1R12A chicken T716 3078001 tIGRSRStRTREQEN X + P38A no information Tip60 10524 Q92993 KAT5 human T158 10800707 VEVVsPAtPVPSETA X +FGFR2 FGFR2 P21802 human FGFR2 2263 P21802 FGFR2 human Y769 448113 TLTTNEEyLDLSQPL X +FGFR2 FGFR2 P21802 human CTNNB1 1499 P35222 CTNNB1 human Y142 449044 AVVNLINyQDDAELA X X +FGFR2 FGFR2 P21802 human ephexin-1 53972 Q8CHT1 Ngef mouse Y177 455579 IEQIGLLyQEyRDKS X +FGFR2 FGFR2 P21802 human PTEN 5728 P60484 PTEN human Y240 448316 RREDKFMyFEFPQPL PTEN_C2 X X +FGFR2 FGFR2 P21802 human GLO1 2739 Q04760 GLO1 human Y136 463450 GIAVPDVysACkRFE Glyoxalase X +FGFR2 FGFR2 P21802 human PIGL 9487 Q9Y2B2 PIGL human Y81 1881980200 LCFSAGNyYNQGETR X X +FGFR2 FGFR2 P21802 human TfR 7037 P02786 TFRC human Y20 448928 FGGEPLsytRFsLAR X +FGFR2 FGFR2 P21802 human GRB2 2885 P62993 GRB2 human Y160 452038 QVPQQPtyVQALFDF X +BRSK1 BRSK1 iso2 Q8TDC3-2 human AMPKA1 5562 Q13131 PRKAA1 human T183 448786 sDGEFLRtsCGsPNy Pkinase X 2535; 2531; 4188; 5256; 50081; 74281 +BRSK1 BRSK1 iso2 Q8TDC3-2 human CDC25B 994 P30305 CDC25B human S375 455380 ARVLRsksLCHDEIE M-inducer_phosp X +BRSK1 BRSK1 iso2 Q8TDC3-2 human CDC25C 995 P30307 CDC25C human S216 448418 sGLyRsPsMPENLNR M-inducer_phosp X X 9528; 4901; 30790 +BRSK1 BRSK1 iso2 Q8TDC3-2 human BRSK1 iso2 84446 Q8TDC3-2 BRSK1 human T205 456027 VGDSLLEtSCGsPHY Pkinase X +BRSK1 BRSK1 iso2 Q8TDC3-2 human Wee1 7465 P30291 WEE1 human S642 455381 KKMNRSVsLtIy___ X 4910 +BRSK1 BRSK1 iso2 Q8TDC3-2 human TUBG1 7283 P23258 TUBG1 human S131 10045600 READGsDsLEGFVLC Tubulin X X +BRSK1 BRSK1 iso2 Q8TDC3-2 human Tau 29477 P19332 Mapt rat S573 447930 NVRSKIGsTENLKHQ Tubulin-binding X +BRSK1 BRSK1 iso2 Q8TDC3-2 human BRSK1 iso2 84446 Q8TDC3-2 BRSK1 human S209 464650 LLEtSCGsPHYACPE Pkinase X +TNK2 Ack Q07912 human N-WASP 682507 O08816 Wasl rat S239 457322 LFDMCGIsEAQLKDR PBD X X +TNK2 Ack Q07912 human CSK 12988 P41241 Csk mouse Y18 41510404 GTECIAKyNFHGTAE SH3_1 X +TNK2 Ack Q07912 human AR 367 P10275 AR human Y365 478251 AyQSRDyyNFPLALA Androgen_recep X +TNK2 Ack Q07912 human Ack 10188 Q07912 TNK2 human Y860 448884 KVsstHyyLLPERPs X +TNK2 Ack Q07912 human Akt1 207 P31749 AKT1 human S473 447855 RPHFPQFsysAsGtA Pkinase_C X 9271; 3787; 4060; 4051; 5102; 4058; 2336; 2337; 4075; 4070; 5012; 4071; 92982; 5315; 9563; 9018; 12694; 52240; 11962; 15116; 88106; 26580; 68035; 31957; 23430; 20235 +TNK2 Ack Q07912 human AR 367 P10275 AR human Y269 478250 QLRGDCMyAPLLGVP Androgen_recep X +TNK2 Ack Q07912 human Ack 10188 Q07912 TNK2 human Y284 450946 LPQNDDHyVMQEHRK PK_Tyr_Ser-Thr X 3138 +TNK2 Ack Q07912 human H4 8359 P62805 H4C1 human Y88 457867 VtAMDVVyALkRQGR CENP-T_C X X +TNK2 Ack Q07912 human PAG 94212 Q3U1F9 Pag1 mouse Y224 450995 GKADFAEyAsVDRNK PAG X +TNK2 Ack Q07912 human p27Kip1 1027 P46527 CDKN1B human Y88 456818 kGsLPEFyyRPPRPP X +TNK2 Ack Q07912 human ATP5A1 498 P25705 ATP5F1A human Y243 461991 SDEkkkLyCIyVAIG ATP-synt_ab X X +TNK2 Ack Q07912 human Ack 10188 Q07912 TNK2 human Y859 448883 KKVsstHyyLLPERP X +TNK2 Ack Q07912 human ATP5A1 498 P25705 ATP5F1A human Y246 477314 kkkLyCIyVAIGQKR ATP-synt_ab X X +TNK2 Ack Q07912 human PAG 94212 Q3U1F9 Pag1 mouse Y314 450659 EEEISAMySSVNKPG PAG X +TNK2 Ack Q07912 human WWOX 51741 Q9NZC7 WWOX human Y287 457684 LSPTKNDyWAMLAYN X +TNK2 Ack Q07912 human PAG 94212 Q3U1F9 Pag1 mouse Y414 448996 HVPKEsDyEsIGDLQ PAG X +TNK2 Ack Q07912 human Ack 51789 O54967 Tnk2 mouse Y284 450946 LPQNDDHyVMQEHRK PK_Tyr_Ser-Thr X 3138 +TNK2 Ack Q07912 human AR 367 P10275 AR human Y535 470068 MDSYSGPyGDMRLET X +TNK2 Ack Q07912 human JMJD1A 55818 Q9Y4C1 KDM3A human Y1114 35527104 ITPEDRKyGTTNLHL X +TNK2 Ack Q07912 human WASP 7454 P42768 WAS human Y291 447985 AEtsKLIyDFIEDQG PBD X +TNK2 Ack Q07912 human N-WASP 682507 O08816 Wasl rat Y253 450253 REtsKVIyDFIEKtG PBD X +Plk1 PLK1 Q62673 rat DYNC1I2 116659 Q62871 Dync1i2 rat T95 469264 PssKSVstPsEAGsQ X +AKT3 Akt3 Q9Y243 human IRF7 54123 P70434 Irf7 mouse S437 486437 SsLGLCLssTNsLYE X 24129 +AKT3 Akt3 Q9Y243 human IRF7 54123 P70434 Irf7 mouse S438 486438 sLGLCLssTNsLYED X 24129 +AKT3 Akt3 Q9Y243 human HSF1 3297 Q00613 HSF1 human S230 448072 PkYSRQFsLEHVHGS X X +AKT3 Akt3 Q9Y243 human ADAR 103 P55265 ADAR human T1033 1868546602 RLGERLRtMSCSDKI A_deamin X +AKT3 Akt3 Q9Y243 human GSK3B 56637 Q9WV60 Gsk3b mouse S9 449111 SGRPRttsFAEsCKP X 9336; 9331; 9327; 9323; 9322; 9325; 5558; 8566; 79774; 8466; 25462; 14026; 14332; 14310; 14630 +AKT3 Akt3 Q9Y243 human RED1 104 P78563 ADARB1 human T553 31884906 LQGERLLtMSCSDKI A_deamin X +AKT3 Akt3 Q9Y243 human p47phox 653361 P14598 NCF1 human S304 449406 GAPPRRssIRNAHsI NECFESHC X +AKT3 Akt3 Q9Y243 human IRF3 54131 P70671 Irf3 mouse S378 448696 MAREGGAssLKTVDL X +AKT3 Akt3 Q9Y243 human AGO2 27161 Q9UKV8 AGO2 human S387 472450 SkLMRsAsFNtDPyV ArgoL2 X X +AKT3 Akt3 Q9Y243 human TSC2 22084 Q61037 Tsc2 mouse T1465 448546 GLRPRGYtISDSAPS X 3617; 3611 +AKT3 Akt3 Q9Y243 human IWS1 55677 Q96ST2 IWS1 human T721 1851496 QRRRMNstGGQtPRR X X +AKT3 Akt3 Q9Y243 human CYCS 54205 P99999 CYCS human Y47 3416311 ktGQAPGysytAANk Cytochrom_C X +AKT3 Akt3 Q9Y243 human RENT1 5976 Q92900 UPF1 human T151 50788283 FCNGRGNtSGSHIVN UPF1_Zn_bind X +AKT3 Akt3 Q9Y243 human TBX3 6926 O15119 TBX3 human S719 23151362 AEkEAAtsELQSIQR X X +AKT3 Akt3 Q9Y243 human BRAF 673 P15056 BRAF human S365 450243 GQRDRsssAPNVHIN X X +AKT3 Akt3 Q9Y243 human RSK2 6197 P51812 RPS6KA3 human T115 1880515604 KVRDRVRtKMERDIL X +AKT3 Akt3 Q9Y243 human BRAF 673 P15056 BRAF human S429 447803 PQRERKsssssEDRN X X +AKT3 Akt3 Q9Y243 human Merlin 4771 P35240 NF2 human S10 1720901 GAIASRMsFSsLkRK X +AKT3 Akt3 Q9Y243 human p47phox 653361 P14598 NCF1 human S328 449404 QDAYRRNsVRFLQQR NECFESHC X +AKT3 Akt3 Q9Y243 human EMSY 56946 Q7Z589 EMSY human T207 1210942 KPRKRRRtNsssssP X +AKT3 Akt3 Q9Y243 human IRF3 3661 Q14653 IRF3 human S385 448696 MARVGGAssLENtVD X +AKT3 Akt3 Q9Y243 human IWS1 55677 Q96ST2 IWS1 human S720 477902 PQRRRMNstGGQtPR X X +AKT3 Akt3 Q9Y243 human EMSY 56946 Q7Z589 EMSY human S209 453526 RKRRRtNsssssPVV X +MAP3K1 MEKK1 Q13233 human MAFA 389692 Q8NHW3 MAFA human S14 1713900 MGAELPSsPLAIEYV X +MAP3K1 MEKK1 Q13233 human MKK7 5609 O14733 MAP2K7 human T275 447698 LVDsKAKtRsAGCAA Pkinase X 4171 +MAP3K1 MEKK1 Q13233 human MEK1 26395 P31938 Map2k1 mouse T292 448287 EtPPRPRtPGRPLsS Pkinase X 26975 +MAP3K1 MEKK1 Q13233 human MKK7 5609 O14733 MAP2K7 human S271 447697 IsGRLVDsKAKtRsA Pkinase X 4171 +MAP3K1 MEKK1 Q13233 human Notch 1 4851 P46531 NOTCH1 human T2511 483083 VPEHPFLtPsPEsPD X +MAP3K1 MEKK1 Q13233 human FADD 8772 Q13158 FADD human S194 447653 QNRsGAMsPMsWNsD X 2781 +MAP3K1 MEKK1 Q13233 human MAFA 389692 Q8NHW3 MAFA human S65 5403102 PCSsVPSsPSFCAPS X +MAP3K1 MEKK1 Q13233 human IKKB 3551 O14920 IKBKB human S181 447489 DQGsLCtsFVGTLQy Pkinase X 2697; 2694; 14938; 92255; 36516; 36214 +TP53RK PRPK Q96S44 human p53 7157 P04637 TP53 human S15 447490 PsVEPPLsQEtFsDL P53_TAD X X 4030; 9235; 9284; 9286; 8695; 8514; 82530; 56979 +ALK ALK Q9UM73 human ALK 238 Q9UM73 ALK human Y1604 447828 tAPGAGHyEDTILkS X 3341 +ALK ALK Q9UM73 human ELP3 55140 Q9H9T3 ELP3 human Y202 450611 GHtSNNIyEAVkySE Radical_SAM X X +ALK ALK Q9UM73 human ALK 238 Q9UM73 ALK human Y1278 450377 FGMARDIyRAsyyRK PK_Tyr_Ser-Thr X 3983; 3710; 6941 +ALK ALK Q9UM73 human CDK9 1025 P50750 CDK9 human Y19 1880104202 FCDEVSkyEkLAkIG X X +ALK ALK Q9UM73 human PSF 6421 P23246 SFPQ human Y293 482843 RRPGEktyTQRCRLF X X +ALK ALK Q9UM73 human ATIC 471 P31939 ATIC human Y104 456299 RVVACNLyPFVkTVA MGS X +ALK ALK Q9UM73 human SNIP 80725 Q9C0H9 SRCIN1 human Y396 456704 LVKGEGLyADPyGLL X +ALK ALK Q9UM73 human STAT3 6774 P40763 STAT3 human Y705 448192 DPGsAAPyLktKFIC X 4093; 9145; 4324; 9131; 9138; 4323; 4074; 4113; 48313; 20977; 25023; 8119; 52075; 52527; 73533; 61958; 73452; 16185; 74309 +ALK ALK Q9UM73 human SHP-2 5781 Q06124 PTPN11 human Y580 448493 REDsARVyENVGLMQ X 3703; 5431; 13328 +ALK ALK Q9UM73 human STAT3 20848 P42227 Stat3 mouse Y705 448192 DPGsAAPyLktkFIC X 4093; 9145; 4324; 9131; 9138; 4323; 4074; 4113; 48313; 20977; 25023; 8119; 52075; 52527; 73533; 61958; 73452; 16185; 74309 +ALK ALK Q9UM73 human PBK 55872 Q96KB5 PBK human Y74 473837 NPICNDHyRsVyQkR Pkinase X +ALK ALK Q9UM73 human VASP 7408 P50552 VASP human Y39 449577 AFSRVQIyHNPtANs WH1 X +ALK ALK Q9UM73 human SHP-2 5781 Q06124 PTPN11 human Y542 448492 sKRkGHEytNIKysL X 3751; 94740; 15543; 64117 +ALK ALK Q9UM73 human GRB2 2885 P62993 GRB2 human Y160 452038 QVPQQPtyVQALFDF X +RPS6KA5 MSK1 O75582 human 4E-BP1 13685 Q60876 Eif4ebp1 mouse S64 447527 FLMECRNsPVAKtPP eIF_4EBP X X 9451; 9456 +RPS6KA5 MSK1 O75582 human MSK1 9252 O75582 RPS6KA5 human S376 448216 EKLFQGysFVAPsIL Pkinase_C X X 9591 +RPS6KA5 MSK1 O75582 human Nur77 15370 P12813 Nr4a1 mouse S354 447942 GRRGRLPsKPKQPPD X 5095 +RPS6KA5 MSK1 O75582 human MSK1 9252 O75582 RPS6KA5 human S381 455795 GysFVAPsILFkRNA X X +RPS6KA5 MSK1 O75582 human LRRC8A 56262 Q8IWT6 LRRC8A human S217 471190 PMLQRtKsRIEQGIV Pannexin_like X +RPS6KA5 MSK1 O75582 human MSK1 9252 O75582 RPS6KA5 human S212 448214 DETERAYsFCGTIEY Pkinase X X +RPS6KA5 MSK1 O75582 human RARA 5914 P10276 RARA human S369 451381 YVRKRRPsRPHMFPK Hormone_recep X X +RPS6KA5 MSK1 O75582 human H3 8350 P68431 H3C1 human S10 455676 tkQtArkstGGkAPr Histone X X 9701; 9711; 9606; 3465; 3642; 3377; 3475; 3458; 5764; 47398; 8481; 8552; 53348; 29237; 66065; 43185; 64522; 52725 +RPS6KA5 MSK1 O75582 human H3 360198 P68433 H3c1 mouse S10 455676 tkQTARkstGGkAPr Histone X 9701; 9711; 9606; 3465; 3642; 3377; 3475; 3458; 5764; 47398; 8481; 8552; 53348; 29237; 66065; 43185; 64522; 52725 +RPS6KA5 MSK1 O75582 human SRF 6722 P11831 SRF human S103 447692 RGLKRsLsEMEIGMV X 4261 +RPS6KA5 MSK1 O75582 human CREB iso1 81646 P15337-1 Creb1 rat S133 448228 EILsRRPsYRkILND pKID X 9187; 9196; 9198; 4095; 14228; 14001; 39561; 80120; 44864; 54960; 95995 +RPS6KA5 MSK1 O75582 human H2A.1 8329 P0C0S8 H2AC17 human S1 451190 _______sGrGkQGG Histone X +RPS6KA5 MSK1 O75582 human H3 8350 P68431 H3C1 human S28 455677 ATkAArksAPATGGV Histone X X 9713 +RPS6KA5 MSK1 O75582 human MSK1 9252 O75582 RPS6KA5 human S752 455797 KMKKTstsTETRsss X X +RPS6KA5 MSK1 O75582 human TIF1B 21849 Q62318 Trim28 mouse S473 452391 SGMkRsRsGEGEVSG X X +RPS6KA5 MSK1 O75582 human CBX3 11335 Q13185 CBX3 human S93 457001 kDGtKRksLsDsEsD X X 2600 +RPS6KA5 MSK1 O75582 human BAD 12015 Q61337 Bad mouse S155 447863 GRELRRMsDEFEGsF Bcl-2_BAD X 9297 +RPS6KA5 MSK1 O75582 human 4E-BP1 13685 Q60876 Eif4ebp1 mouse T36 447497 PPGDysttPGGtLFs eIF_4EBP X 2855; 9459; 2846; 4923; 5123; 3929; 7547; 45613; 39788 +RPS6KA5 MSK1 O75582 human CREB 1385 P16220 CREB1 human S119 448228 EILsRRPsyRkILND pKID X X 9187; 9196; 9198; 4095; 14228; 14001; 39561; 80120; 44864; 54960; 95995 +RPS6KA5 MSK1 O75582 human NFkB-p65 19697 Q04207 Rela mouse S276 447798 SMQLRRPsDRELSEP RHD_dimer X +RPS6KA5 MSK1 O75582 human JMJD1A 55818 Q9Y4C1 KDM3A human S264 8100021 IGAVKRKssENNGTL X X +RPS6KA5 MSK1 O75582 human MSK1 9252 O75582 RPS6KA5 human S750 455796 RRKMKKTstsTETRs X X +RPS6KA5 MSK1 O75582 human ataxin-1 6310 P54253 ATXN1 human S775 449110 AtRKRRWsAPESRKL X X +RPS6KA5 MSK1 O75582 human ATF-1 466 P18846 ATF1 human S63 449762 GILARRPsyRKILkD pKID X X 4095; 14228; 14001 +RPS6KA5 MSK1 O75582 human NFkB-p65 5970 Q04206 RELA human S276 447798 sMQLRRPsDRELsEP RHD_dimer X X +RPS6KA5 MSK1 O75582 human WNK1 65125 Q9H4A3 WNK1 human T60 450948 EYRRRRHtMDKDSrG X 4946 +RPS6KA5 MSK1 O75582 human H3 360198 P68433 H3c1 mouse S28 455677 ATkAArksAPATGGV Histone X 9713 +RPS6KA5 MSK1 O75582 human ELK1 2002 P19419 ELK1 human S383 447872 IHFWSTLsPIAPRsP X 9181; 9186 +RPS6KA5 MSK1 O75582 human CREB 12912 Q01147 Creb1 mouse S119 448228 EILsRRPsyRkILND pKID X 9187; 9196; 9198; 4095; 14228; 14001; 39561; 80120; 44864; 54960; 95995 +RPS6KA5 MSK1 O75582 human TH iso3 7054 P07101-3 TH human S40 448545 RFIGRRQsLIEDARK TOH_N X 2791 +RPS6KA5 MSK1 O75582 human MSK1 9252 O75582 RPS6KA5 human S758 455798 tsTETRssssESSHS X X +RPS6KA5 MSK1 O75582 human H2A.1 319172 C0HKE1 H2ac4 mouse S1 451190 _______sGRGkQGG Histone X +EGFR EGFR P00533 human G-alpha i1 2770 P63096 GNAI1 human Y320 22641096 RKDTkEIyTHFTCAT G-alpha X X +EGFR EGFR P00533 human GSTP1 2950 P09211 GSTP1 human Y8 459294 MPPyTVVyFPVRGRC GST_N X X +EGFR EGFR P00533 human SHC1 iso3 6464 P29353-3 SHC1 human Y194 448509 EEPPDHQyyNDFPGK X +EGFR EGFR P00533 human GSTP1 2950 P09211 GSTP1 human Y4 462289 ____MPPyTVVyFPV GST_N X X +EGFR EGFR P00533 human EPS15 13858 P42567 Eps15 mouse Y850 450484 NFANFSAyPsEEDMI X +EGFR EGFR P00533 human PKCD 170538 P09215 Prkcd rat Y311 447573 TPETVGIyQGFEKKT X 2055 +EGFR EGFR P00533 human SHC1 iso3 6464 P29353-3 SHC1 human Y272 448511 ELFDDPSyVNVQNLD X +EGFR EGFR P00533 human VAV2 7410 P52735 VAV2 human Y172 452202 EDGGDDIyEDIIKVE X +EGFR EGFR P00533 human GRK2 282682 P21146 GRK2 cow Y92 456873 FyEEIKKyEKLETEE RGS X X +EGFR EGFR P00533 human CTNNB1 1499 P35222 CTNNB1 human Y142 449044 AVVNLINyQDDAELA X X +EGFR EGFR P00533 human SHC1 iso2 6464 P29353-2 SHC1 human Y239 448509 EEPPDHQyyNDFPGK X X +EGFR EGFR P00533 human PIP5K1C 18717 O70161 Pip5k1c mouse Y634 486321 DAPSTDIyFPTDERS X +EGFR EGFR P00533 human GAB1 2549 Q13480 GAB1 human Y406 447946 DAssQDCyDIPRAFP X +EGFR EGFR P00533 human PELI1 57162 Q96FA3 PELI1 human T264 1881000300 EGLSHTPtVkHLEAL X +EGFR EGFR P00533 human Calmodulin 24242 P0DP29 Calm3 rat Y100 448707 FDkDGNGyIsAAELR EF-hand_7 X +EGFR EGFR P00533 human beclin 1 8678 Q14457 BECN1 human Y233 477225 EAQyQREysEFkRQQ APG6_N X X +EGFR EGFR P00533 human RAIG1 9052 Q8NFJ5 GPRC5A human Y350 450339 WPsPykDyEVkKEGs X +EGFR EGFR P00533 human PLCG1 281987 P08487 PLCG1 cow Y472 447666 KLAEGSAyEEVPTSV X +EGFR EGFR P00533 human SQSTM1 8878 Q13501 SQSTM1 human Y433 11112748 AALDtIQyskHPPPL UBA_5 X +EGFR EGFR P00533 human PKIA 100343293 P61926 LOC100343293 rabbit Y8 451401 MTDVETTyADFIASG PKI X +EGFR EGFR P00533 human SCD 6319 O00767 SCD human Y14 457823 QDDISSSyTTTTTIT X X +EGFR EGFR P00533 human ANXA1 301 P04083 ANXA1 human Y21 447974 IENEEQEyVQtVkss X +EGFR EGFR P00533 human SCD 6319 O00767 SCD human Y55 3411245 PDIkDDIyDPTykDk X X +EGFR EGFR P00533 human Calmodulin 24242 P0DP29 Calm3 rat Y139 448708 DGDGQVNyEEFVQMM EF-hand_7 X +EGFR EGFR P00533 human HIP1 3092 O00291 HIP1 human Y152 28704600 LLRTKMEyHTkNPRF ANTH X +EGFR EGFR P00533 human PLCG1 25738 P10686 Plcg1 rat Y1253 448576 EGsFEARyQQPFEDF X +EGFR EGFR P00533 human beclin 1 8678 Q14457 BECN1 human Y229 28850302 LDQEEAQyQREysEF APG6_N X X +EGFR EGFR P00533 human PTP1B 5770 P18031 PTPN1 human Y66 447812 LHQEDNDyINAsLIk Y_phosphatase X X +EGFR EGFR P00533 human EGFR 1956 P00533 EGFR human Y1092 448057 tFLPVPEyINQsVPk X X 2236; 2234; 3777; 14565; 8543; 48576 +EGFR EGFR P00533 human GAB1 2549 Q13480 GAB1 human Y659 447949 VADERVDyVVVDQQK X 12745 +EGFR EGFR P00533 human SHC1 iso2 6464 P29353-2 SHC1 human Y240 448510 EPPDHQyyNDFPGKE X X +EGFR EGFR P00533 human GAB1 2549 Q13480 GAB1 human Y373 447945 AsDtDssyCIPTAGM X +EGFR EGFR P00533 human SHC3 iso2 53358 Q92529-2 SHC3 human Y218 451254 GDGSDHPyyNSIPSK X +EGFR EGFR P00533 human HIR 3761 P48050 KCNJ4 human Y234 19003800 YMTQEGEyLPLDQRD IRK_C X +EGFR EGFR P00533 human GAB1 2549 Q13480 GAB1 human Y589 449792 SHDSEENyVPMNPNL X +EGFR EGFR P00533 human SHC3 iso2 53358 Q92529-2 SHC3 human Y256 451255 FAGKEQTyyQGRHLG X +EGFR EGFR P00533 human PPP2CA 5515 P67775 PPP2CA human Y307 448571 VTRRtPDyFl_____ X +EGFR EGFR P00533 human PKM 5315 P14618 PKM human Y148 454768 kItLDNAyMEkCDEN PK X X +EGFR EGFR P00533 human GRF-1 232906 Q91YM2 Arhgap35 mouse Y1105 448941 RNEEENIysVPHDST RhoGAP_pG1_pG2 X +EGFR EGFR P00533 human USP8 9101 P40818 USP8 human Y810 23071951 DYFNRNCyQDDINRS UCH X +EGFR EGFR P00533 human DDEFL1 55616 Q8TDY4 ASAP3 human Y34 28704100 FAAKMPRyRGAALAR BAR_3 X X +EGFR EGFR P00533 human G-alpha i1 2770 P63096 GNAI1 human Y155 5688819 LNDSAAyyLNDLDRI G-alpha X X +EGFR EGFR P00533 human PELI1 57162 Q96FA3 PELI1 human Y154 3800785 PPFTARIyAAGFDSS Pellino X +EGFR EGFR P00533 human EGFR 1956 P00533 EGFR human Y1110 448058 GsVQNPVyHNQPLNP X X 2220 +EGFR EGFR P00533 human PLCG1 281987 P08487 PLCG1 cow Y783 447667 EGRNPGFyVEANPMP X +EGFR EGFR P00533 human KCNN1 3780 Q92952 KCNN1 human Y109 17436177 KRKRLsDyALIFGMF SK_channel X +EGFR EGFR P00533 human girdin 55704 Q3V6T2 CCDC88A human Y1799 450762 QSkDsNPyAtLPRAS X +EGFR EGFR P00533 human EGFR 1956 P00533 EGFR human Y1197 448060 stAENAEyLRVAPQS X X 2244; 4407; 47737 +EGFR EGFR P00533 human AGO2 27161 Q9UKV8 AGO2 human Y393 17533102 AsFNtDPyVREFGIM ArgoL2 X +EGFR EGFR P00533 human DNAPK 5591 P78527 PRKDC human T2609 448710 LtPMFVEtQAsQGtL DNAPKcs_CC5 X +EGFR EGFR P00533 human VAV2 7410 P52735 VAV2 human Y142 452200 TENDDDVyRSLEELA X +EGFR EGFR P00533 human RAIG1 9052 Q8NFJ5 GPRC5A human Y320 455045 GDtLyAPystHFQLQ X +EGFR EGFR P00533 human CRK 54245 Q63768 Crk rat Y221 447951 GGPEPGPyAQPsVNt X 3491 +EGFR EGFR P00533 human PFKP 5214 Q01813 PFKP human Y64 1426260400 VYFIYEGyQGMVDGG PFK X X +EGFR EGFR P00533 human GLUD1 14661 P26443 Glud1 mouse Y135 3552510 sWEVIEGyRAQHSQH ELFV_dehydrog_N X X +EGFR EGFR P00533 human SHC1 iso2 6464 P29353-2 SHC1 human Y317 448511 ELFDDPSyVNVQNLD X X +EGFR EGFR P00533 human STING 340061 Q86WV6 STING1 human Y245 1869808400 RVysNSIyELLENGQ TMEM173 X X +EGFR EGFR P00533 human PLCG1 281987 P08487 PLCG1 cow Y771 448575 IGTAEPDyGALyEGR X +EGFR EGFR P00533 human CCDC50 152137 Q8IVM0 CCDC50 human Y304 6377636 SSHkGFHyKH_____ X +EGFR EGFR P00533 human EGFR 1956 P00533 EGFR human Y1016 448055 DVVDADEyLIPQQGF X X 2235 +EGFR EGFR P00533 human ER-alpha 2099 P03372 ESR1 human S118 448101 LHPPPQLsPFLQPHG Oest_recep X 2511 +EGFR EGFR P00533 human PLCG1 5335 P19174 PLCG1 human Y771 448575 IGtAEPdyGALyEGR X +EGFR EGFR P00533 human FAK 5747 Q05397 PTK2 human Y5 7445815 ___MAAAyLDPNLNH X X +EGFR EGFR P00533 human PCNA 5111 P12004 PCNA human Y211 471414 QLTFALryLNFFtkA PCNA_C X X +EGFR EGFR P00533 human SPRED1 161742 Q7Z699 SPRED1 human S105 36131862 KFGLTFQsPADARAF WH1 X +EGFR EGFR P00533 human PLD2 5338 O14939 PLD2 human Y296 10036102 LILkCSSyRQARWWA X +EGFR EGFR P00533 human USP8 9101 P40818 USP8 human Y717 484371 PsKLKRsyssPDItQ X +EGFR EGFR P00533 human SCD 6319 O00767 SCD human Y41 3411240 kLETMPLyLEDDIRP X X +EGFR EGFR P00533 human EGFR 1956 P00533 EGFR human Y869 448061 LGAEEkEyHAEGGkV PK_Tyr_Ser-Thr X 2231; 6963 +EGFR EGFR P00533 human ACTN4 60595 P57780 Actn4 mouse Y4 11498501 ____MVDyHAANQAY X +EGFR EGFR P00533 human VAV2 7410 P52735 VAV2 human Y159 452201 HDLGEDIyDCVPCED X +EGFR EGFR P00533 human beclin 1 8678 Q14457 BECN1 human Y352 28850301 KSKELPLyCSGGLRF APG6 X X +EGFR EGFR P00533 human PLCG1 25738 P10686 Plcg1 rat Y783 447667 EGRNPGFyVEANPMP X 2821; 14461; 14008; 25678; 88717 +EGFR EGFR P00533 human PKCD 170538 P09215 Prkcd rat Y332 450077 IPDNNGTyGKIWEGS X +EGFR EGFR P00533 human EPB41 iso4 2035 P11171-4 EPB41 human Y418 451704 RLDGENIyIRHSNLM X +EGFR EGFR P00533 human GAB1 2549 Q13480 GAB1 human Y447 449791 SEELDENyVPMNPNs X +EGFR EGFR P00533 human ACTN4 60595 P57780 Actn4 mouse Y32 11498502 GGGSMGDyMAQEDDW X +EGFR EGFR P00533 human GAB1 2549 Q13480 GAB1 human Y472 447947 EPIQEANyVPMtPGT X +EGFR EGFR P00533 human SHC1 iso3 6464 P29353-3 SHC1 human Y195 448510 EPPDHQyyNDFPGKE X +EGFR EGFR P00533 human FAM129B 64855 Q96TA1 NIBAN2 human Y593 25299904 PIDWGEEysNSGGGG X X +EGFR EGFR P00533 human HDAC6 10013 Q9UBN7 HDAC6 human Y570 12127406 SSNFDSIyICPSTFA Hist_deacetyl X +EGFR EGFR P00533 human LRRK1 79705 Q38SD2 LRRK1 human Y971 23303206 TQQTEEQyFQFLAKF COR X X +EGFR EGFR P00533 human ATM 472 Q13315 ATM human Y370 38535268 SLEIsQSyTttQRES X X +EGFR EGFR P00533 human PDP1 54704 Q9P0J1 PDP1 human Y381 15422118 DQLNDNEyTkFIPPN PP2C X +EGFR EGFR P00533 human PLCG1 5335 P19174 PLCG1 human Y783 447667 EGRNPGFyVEANPMP X 2821; 14461; 14008; 25678; 88717 +EGFR EGFR P00533 human HDAC1 3065 Q13547 HDAC1 human Y72 55375010 TkYHSDDyIkFLRSI Hist_deacetyl X +EGFR EGFR P00533 human TLR3 7098 O15455 TLR3 human Y858 25680401 FLEEIPDyKLNHALC TIR X X +EGFR EGFR P00533 human ABCA1 19 O95477 ABCA1 human S2054 455498 GGNkRKLsTAMALIG ABC_tran X +EGFR EGFR P00533 human RGS16 6004 O15492 RGS16 human Y168 448652 TLMEKDSyPRFLkSP RGS X +EGFR EGFR P00533 human G-alpha i1 2770 P63096 GNAI1 human Y154 1871177702 QLNDSAAyyLNDLDR G-alpha X X +EGFR EGFR P00533 human FAK 5747 Q05397 PTK2 human Y194 18122800 ALEKKSNyEVLEkDV FERM_M X X +EGFR EGFR P00533 human CTNNB1 1499 P35222 CTNNB1 human Y654 447585 RNEGVAtyAAAVLFR X +EGFR EGFR P00533 human Daple 440193 Q9P219 CCDC88C human Y2025 899136400 PQTVWyEyGCV____ X +EGFR EGFR P00533 human Ezrin 7430 P15311 EZR human Y354 448105 LMLRLQDyEEktKKA ERM_helical X 3144; 5484 +EGFR EGFR P00533 human TRIP13 9319 Q15645 TRIP13 human Y206 35479941 RLSSRYRyGQLIEIN AAA X +EGFR EGFR P00533 human LYN 4067 P07948 LYN human Y32 454717 RNTERtIyVRDPTSN X X +EGFR EGFR P00533 human GAB1 2549 Q13480 GAB1 human Y285 449801 TEADGELyVFNTPSG X +EGFR EGFR P00533 human ZNRF1 170737 Q91V17 Znrf1 mouse Y103 479016 TyAHGNGyQETGGGH X +EGFR EGFR P00533 human GSTP1 2950 P09211 GSTP1 human Y199 463460 AFLAsPEyVNLPING X X +EGFR EGFR P00533 human CCDC50 152137 Q8IVM0 CCDC50 human Y279 462101 tDGEDADytHFtNQQ X +EGFR EGFR P00533 human SOX2 6657 P48431 SOX2 human Y277 27722639 LRDMISMyLPGAEVP X +EGFR EGFR P00533 human IKKE 9641 Q14164 IKBKE human Y179 23115344 sVYGTEEyLHPDMYE Pkinase X +EGFR EGFR P00533 human Kv4.3 3752 Q9UK17 KCND3 human Y136 23045803 GDCCYEEyKDRKREN X +EGFR EGFR P00533 human RAIG1 9052 Q8NFJ5 GPRC5A human Y317 451750 EEtGDtLyAPystHF X +EGFR EGFR P00533 human girdin 55704 Q3V6T2 CCDC88A human Y1765 450761 PRktEDtyFISSAGk X +EGFR EGFR P00533 human GRK2 282682 P21146 GRK2 cow Y86 447727 AKPLVEFyEEIKKyE RGS X X +EGFR EGFR P00533 human CCDC50 152137 Q8IVM0 CCDC50 human Y217 6377637 MAEEkKAykkAkERE X +EGFR EGFR P00533 human RAIG1 9052 Q8NFJ5 GPRC5A human Y347 450338 AHAWPsPykDyEVkK X +EGFR EGFR P00533 human SHC3 iso2 53358 Q92529-2 SHC3 human Y301 451259 PTGEAPTyVNTQQIP X +EGFR EGFR P00533 human Ezrin 7430 P15311 EZR human Y146 448758 kEVHksGyLSsERLI FERM_M X +EGFR EGFR P00533 human MRLC3 10627 P19105 MYL12A human Y155 7382105 DkkGNFNyIEFTRIL EF-hand_11 X +EGFR EGFR P00533 human SHC3 iso2 53358 Q92529-2 SHC3 human Y257 451256 AGKEQTyyQGRHLGD X +EGFR EGFR P00533 human PPAR-delta 5467 Q03181 PPARD human Y108 1868968410 TIRMKLEyEKCERSC zf-C4 X X +EGFR EGFR P00533 human GRK2 282682 P21146 GRK2 cow Y13 456872 AVLADVSyLMAMEKS X X +EGFR EGFR P00533 human SHC3 iso2 53358 Q92529-2 SHC3 human Y283 451257 RQGSSDIySTPEGKL X +EGFR EGFR P00533 human RASA1 25676 P50904 Rasa1 rat Y451 449959 TVDGKEIyNTIRRKT X X +EGFR EGFR P00533 human PPAR-gamma iso2 5468 P37231-2 PPARG human Y74 9256871 YDLKLQEyQSAIkVE PPARgamma_N X X +EGFR EGFR P00533 human SHC3 iso2 53358 Q92529-2 SHC3 human Y219 451258 DGSDHPyyNSIPSKM X +EGFR EGFR P00533 human EGFR 1956 P00533 EGFR human Y1172 448059 IsLDNPDyQQDFFPk X X 4404 +EGFR EGFR P00533 human GAB1 2549 Q13480 GAB1 human Y627 447948 KGDKQVEyLDLDLDs X 3231; 3233 +EGFR EGFR P00533 human TRIP13 9319 Q15645 TRIP13 human Y56 450833 HNIVFGDyTWTEFDE X X +EGFR EGFR P00533 human PLCG1 281987 P08487 PLCG1 cow Y1254 448576 EGsFEARyQQPFEDF X +EGFR EGFR P00533 human IKKE 9641 Q14164 IKBKE human Y153 56589701 GEEGQSIykLTDFGA Pkinase X +MYLK2 skMLCK P07313 rabbit skMLCK P07313 MYLK2 rabbit S235 2869608 AKVQGDTsRGIEFQA X +MYLK2 skMLCK P07313 rabbit skMLCK P07313 MYLK2 rabbit S161 2864200 PAFLHSPsCPAIIAS X +PAK2 PAK2 Q13177 human smMLCK 100009143 P29294 MYLK rabbit S991 452099 VRAIGRLsSMAMISG X +PAK2 PAK2 Q13177 human Myc 4609 P01106 MYC human S388 450961 RRNELkRsFFALRDQ HLH X X +PAK2 PAK2 Q13177 human ARHGAP15 55843 Q53QZ3 ARHGAP15 human S292 28712601 kVCERENsTVPWFVk X +PAK2 PAK2 Q13177 human H4 8359 P62805 H4C1 human S47 449870 RGGVKrIsGLIyEEt CENP-T_C X X +PAK2 PAK2 Q13177 human Jun 3725 P05412 JUN human T2 17737603 ______MtAKMETtF X X +PAK2 PAK2 Q13177 human Caldesmon 800 Q05682 CALD1 human S744 456707 GLKVGVSsRINEWLT Caldesmon X +PAK2 PAK2 Q13177 human Jun 3725 P05412 JUN human T286 17737605 RLEEKVKtLKAQNSE bZIP_1 X X +PAK2 PAK2 Q13177 human Myc 4609 P01106 MYC human T373 450960 EENVkRRtHNVLERQ HLH X +PAK2 PAK2 Q13177 human MICAL1 64780 Q8TDZ2 MICAL1 human S817 5434440 sPERQRLssLNLtPD X +PAK2 PAK2 Q13177 human SORT1 6272 Q99523 SORT1 human S793 3823097 RFLVHRYsVLQQHAE X +PAK2 PAK2 Q13177 human RhoGDI alpha 360678 Q5XI73 Arhgdia rat S101 452195 LESFKkQsFVLkEGV Rho_GDI X X +PAK2 PAK2 Q13177 human Mnk1 17346 O08605 Mknk1 mouse T34 454028 RRKKKRKtRATDsLP X +PAK2 PAK2 Q13177 human CASP7 840 P55210 CASP7 human S239 20473607 WRsPGRGsWFVQALC Peptidase_C14 X X +PAK2 PAK2 Q13177 human Abl 25 P00519 ABL1 human S619 1779805 PtPPKRsssFREMDG X X +PAK2 PAK2 Q13177 human PAK2 5062 Q13177 PAK2 human S192 448296 PRPDHTksIytRsVI X 2605 +PAK2 PAK2 Q13177 human smMLCK 100009143 P29294 MYLK rabbit S439 452098 MKSRRPKsSLPPVLG X +PAK2 PAK2 Q13177 human PAK2 5062 Q13177 PAK2 human S141 448295 tVkQKyLsFtPPEkd X 2606 +PAK2 PAK2 Q13177 human SMAD2 4087 Q15796 SMAD2 human S467 447495 sVRCssMs_______ X 3108; 8828; 11979; 26945; 55041; 68550; 18338; 56532; 67804 +PAK2 PAK2 Q13177 human Merlin 4771 P35240 NF2 human S518 448282 DTDMKRLsMEIEKEK ERM_C X X 9163; 13281 +PAK2 PAK2 Q13177 human SMAD2 4087 Q15796 SMAD2 human S417 447569 RMCTIRMsFVkGWGA MH2 X X +PAK2 PAK2 Q13177 human eIF4G 1981 Q04637 EIF4G1 human S895 458380 RDIARRRsLGNIkFI MIF4G X +PAK2 PAK2 Q13177 human ARHGAP15 55843 Q53QZ3 ARHGAP15 human S4 28712600 ____MQKsTNsDTSV X +PAK2 PAK2 Q13177 human RORC 19885 P51450 Rorc mouse S337 25308318 VEFAKRLsGFMELCQ Hormone_recep X X +PAK2 PAK2 Q13177 human SYN1 281510 P17599 SYN1 cow S551 451574 PATRPPAsPsPQRQA X +PAK2 PAK2 Q13177 human ARHGAP15 55843 Q53QZ3 ARHGAP15 human S43 14159324 DRLsQsksMILTDVG X +PAK2 PAK2 Q13177 human PAK2 5062 Q13177 PAK2 human T402 448300 PEQSkRstMVGtPYW Pkinase X 2601 +PAK2 PAK2 Q13177 human RhoGDI alpha 360678 Q5XI73 Arhgdia rat S34 467490 YkPPAQKsIQEIQEL Rho_GDI X X +PAK2 PAK2 Q13177 human PAK2 224105 Q8CIN4 Pak2 mouse S141 448295 TVkQKyLsFtPPEKD X 2606 +PAK2 PAK2 Q13177 human Jun 3725 P05412 JUN human T8 17737604 MtAKMETtFYDDALN Jun X X +PAK2 PAK2 Q13177 human SMAD2 4087 Q15796 SMAD2 human S465 447494 sPsVRCssMs_____ X 3108; 8828; 11979; 26945; 55041; 68550; 18338; 56532; 67804 +PAK2 PAK2 Q13177 human Myc 4609 P01106 MYC human T415 450962 VVILKkAtAYILsVQ HLH X +PAK2 PAK2 Q13177 human PXN 5829 P49023 PXN human S272 465466 ELDELMAsLsDFkIQ X +PAK2 PAK2 Q13177 human CASP7 840 P55210 CASP7 human S30 12069580 DAKPDRssFVPsLFs X X +PAK2 PAK2 Q13177 human Caldesmon 800 Q05682 CALD1 human S714 456706 EGVRNIksMWEkGNV Caldesmon X +PAK2 PAK2 Q13177 human ARHGAP15 55843 Q53QZ3 ARHGAP15 human S41 23083229 HHDRLsQsksMILTD X +PAK2 PAK2 Q13177 human ERK3 5597 Q16659 MAPK6 human S189 448267 ySHKGHLsEGLVTkW Pkinase X +PAK2 PAK2 Q13177 human PXN 5829 P49023 PXN human S274 465490 DELMAsLsDFkIQGL X +PAK2 PAK2 Q13177 human PAK2 5062 Q13177 PAK2 human S197 448297 TksIytRsVIDPVPA X 2605 +PAK2 PAK2 Q13177 human CASP7 840 P55210 CASP7 human T173 20473606 FRGDRCktLLEkPKL Peptidase_C14 X X +PAK2 PAK2 Q13177 human CTNNB1 1499 P35222 CTNNB1 human S552 472273 QDtQRRtsMGGtQQQ X 9566; 5651 +PAK2 PAK2 Q13177 human Mnk1 17346 O08605 Mknk1 mouse S39 454027 RKtRATDsLPGKFED X +PAK2 PAK2 Q13177 human SYN1 281510 P17599 SYN1 cow S605 450236 AGPTRQAsQAGPMPR X +PAK2 PAK2 Q13177 human SMAD2 4087 Q15796 SMAD2 human S464 447567 GsPsVRCssMs____ X +PAK2 PAK2 Q13177 human Jun 3725 P05412 JUN human T89 17737602 QSSNGHItTtPtPtQ Jun X X +PAK2 PAK2 Q13177 human SYN1 281510 P17599 SYN1 cow S9 448378 NYLRRRLsDSNFMAN Synapsin_N X +PAK2 PAK2 Q13177 human PREX2 80243 Q70Z35 PREX2 human S1107 35483225 DTISNRDsYSDCNSN X +PAK2 PAK2 Q13177 human RAF1 5894 P04049 RAF1 human S338 447742 RPRGQRDssyyWEIE X X 9427 +PAK2 PAK2 Q13177 human MICAL1 64780 Q8TDZ2 MICAL1 human S960 6226101 ELALRRQssSPEQQK bMERB_dom X +PAK2 PAK2 Q13177 human HACE1 57531 Q8IYU2 HACE1 human S385 10940679 LMKNKRDsTEITsIL X +PAK2 PAK2 Q13177 human SLC25A5 292 P05141 SLC25A5 human T107 1876923700 LGGVDkRtQFWLyFA X +PAK2 PAK2 Q13177 human Jun 3725 P05412 JUN human T93 450449 GHItTtPtPtQFLCP Jun X X 2993 +PAK2 PAK2 Q13177 human Abl 25 P00519 ABL1 human S618 1779804 APtPPKRsssFREMD X X +MAP4K5 KHS1 Q9Y4K4 human GSK3B 56637 Q9WV60 Gsk3b mouse S9 449111 SGRPRttsFAEsCKP X 9336; 9331; 9327; 9323; 9322; 9325; 5558; 8566; 79774; 8466; 25462; 14026; 14332; 14310; 14630 +MAP4K5 KHS1 Q9Y4K4 human GSK3B 2932 P49841 GSK3B human S9 449111 SGRPRttsFAEsCkP X X 9336; 9331; 9327; 9323; 9322; 9325; 5558; 8566; 79774; 8466; 25462; 14026; 14332; 14310; 14630 +Nlk NLK O54949 mouse Huntingtin 15194 P42859 Htt mouse S120 1869087500 LCSNDAEsDVRMVAD X X +NTRK3 TrkC Q16288 human NLGN1 192167 Q99K10 Nlgn1 mouse Y782 1008111 RTACPPDyTLAMRRS X +Mastl MASTL Q8C0P0 mouse ENSA 56205 P60840 Ensa mouse S67 455934 KGQkyFDsGDyNMAK Endosulfine X 5240 +Mapk9 JNK2 Q9WTU6 mouse DLK 26404 Q60700 Map3k12 mouse S533 27447446 RNVPQKLsPHSKRPD X X +Mapk9 JNK2 Q9WTU6 mouse NFAT3 4776 Q14934 NFATC4 human S217 953803 GLGsPLPsPRAsPRP X +Mapk9 JNK2 Q9WTU6 mouse BMAL1 406 O00327 BMAL1 human S592 25352000 DNDQGSSsPSNDEAA X +Mapk9 JNK2 Q9WTU6 mouse RXRA 20181 P28700 Rxra mouse S265 450891 NMGLNPSsPNDPVTN Hormone_recep X +Mapk9 JNK2 Q9WTU6 mouse BMAL1 406 O00327 BMAL1 human S520 25352001 SPSSCGSsPLNITSt X +Mapk9 JNK2 Q9WTU6 mouse LISCH iso2 54135 Q99KG5-2 Lsr mouse S288 4771509 PGDFDRTsSVGGHSS X +Mapk9 JNK2 Q9WTU6 mouse RXRA 20181 P28700 Rxra mouse S61 453094 SPISTLSsPINGMGP Nuc_recep-AF1 X +Mapk9 JNK2 Q9WTU6 mouse DLK 26404 Q60700 Map3k12 mouse T43 4727854 CtPEKDLtPTQCVLR X X +Mapk9 JNK2 Q9WTU6 mouse BIM 12125 O54918 Bcl2l11 mouse S65 449330 GPLAPPAsPGPFATR X 4581; 4585 +Mapk9 JNK2 Q9WTU6 mouse RXRA 20181 P28700 Rxra mouse S75 453095 PPFSVISsPMGPHSM Nuc_recep-AF1 X +Mapk9 JNK2 Q9WTU6 mouse RXRA 20181 P28700 Rxra mouse T87 453096 HSMSVPTtPTLGFGT Nuc_recep-AF1 X +Mapk9 JNK2 Q9WTU6 mouse NFAT3 4776 Q14934 NFATC4 human S213 953804 ASRFGLGsPLPsPRA X +Mapk9 JNK2 Q9WTU6 mouse H3 iso3 15081 P84244 H3f3b mouse S28 455677 ATkAArksAPSTGGV Histone X 9713 +Mapk9 JNK2 Q9WTU6 mouse Jun 16476 P05627 Jun mouse S63 447686 kNsDLLtsPDVGLLK Jun X 5464; 9261; 2361; 97721; 91952 +Mapk9 JNK2 Q9WTU6 mouse p70S6K 6198 P23443 RPS6KB1 human S434 448356 sFEPKIRsPRRFIGs X +Mapk9 JNK2 Q9WTU6 mouse H2AX 15270 P27661 H2ax mouse S139 448841 GkKAsQAsQEy____ X X 2577; 9719; 9720; 9718; 4309; 5763; 5438; 93629; 80312; 20304; 85410; 97148; 60566; 59141 +Mapk9 JNK2 Q9WTU6 mouse Ets-2 23872 P15037 Ets2 mouse T72 447688 SCELPLLtPCSKAVM X +Mapk9 JNK2 Q9WTU6 mouse BMAL1 406 O00327 BMAL1 human T527 448633 sPLNITStPPPDASS X +Jak2 JAK2 Q62689 rat STAT5A 24918 Q62771 Stat5a rat Y694 447767 LAKAVDGyVKPQIKQ X 9365; 9356; 9359; 9351; 4322; 9314; 3939; 40284; 5387; 14603; 66740; 51879; 72712 +Jak2 JAK2 Q62689 rat GH receptor 25235 P16310 Ghr rat Y338 455508 DNyKPDFyNDDSWVE GHBP X +Jak2 JAK2 Q62689 rat STAT5B 25126 P52632 Stat5b rat Y699 448198 TAKAADGyVKPQIKQ X 9365; 9356; 9359; 9351; 4322; 9314; 3939; 40284; 5387; 14603; 66740; 51879; 72712 +Jak2 JAK2 Q62689 rat GH receptor 25235 P16310 Ghr rat Y333 455507 ILGIHDNyKPDFyND GHBP X +Eef2k EEF2K P70531 rat EEF2 29565 P05197 Eef2 rat T57 448040 RAGEtRFtDtRKDEQ GTP_EFTU X X 2331 +STK17A DRAK1 Q9UEE5 human p53 7157 P04637 TP53 human S20 447529 PLsQEtFsDLWkLLP P53_TAD X 9287 +Map3k1 MEKK1 P53349 mouse MEK1 170851 Q01986 Map2k1 rat S218 448514 VsGQLIDsMANsFVG Pkinase X 9121; 3958; 9154; 86128 +Map3k1 MEKK1 P53349 mouse MEKK1 26401 P53349 Map3k1 mouse T1393 448079 FQGQLLGtIAFMAPE Pkinase X +Map3k1 MEKK1 P53349 mouse MEKK1 26401 P53349 Map3k1 mouse T1381 448078 ARLASKGtGAGEFQG Pkinase X X +Map3k1 MEKK1 P53349 mouse STAT3 20848 P42227 Stat3 mouse S727 448191 NtIDLPMsPRTLDSL X X 9134; 9136; 34911; 94994; 49081; 58978; 87544; 71958; 50804 +Map3k1 MEKK1 P53349 mouse MEK1 170851 Q01986 Map2k1 rat S222 448513 LIDsMANsFVGTRSY Pkinase X 2338; 9121; 3958; 9154; 16211; 86128; 16780; 75262 +MAPK15 ERK7 Q8TD08 human ERK7 225689 Q8TD08 MAPK15 human T381 459223 DPQLPsRtPVQGPRP X +MAPK15 ERK7 Q8TD08 human ERK7 225689 Q8TD08 MAPK15 human Y177 459217 EDQAVtEyVATRWYR Pkinase X X +MAPK15 ERK7 Q8TD08 human ERK7 225689 Q8TD08 MAPK15 human S192 459218 APEVLLSsHRYTLGV Pkinase X +MAPK15 ERK7 Q8TD08 human ERK7 225689 Q8TD08 MAPK15 human S331 459219 AHEGVQLsVPEYRSR X +MAPK15 ERK7 Q8TD08 human ERK7 225689 Q8TD08 MAPK15 human S362 459221 EKGPEGVsPSQAHLH X +MAPK15 ERK7 Q8TD08 human IkB-alpha 4792 P25963 NFKBIA human S32 448203 LLDDRHDsGLDsMkD X X 5210; 2859; 9246; 5209 +MAPK15 ERK7 Q8TD08 human ERK7 225689 Q8TD08 MAPK15 human S379 459222 RADPQLPsRtPVQGP X +MAPK15 ERK7 Q8TD08 human IkB-alpha 4792 P25963 NFKBIA human S36 448204 RHDsGLDsMkDEEyE X X 5210; 9246 +MAPK15 ERK7 Q8TD08 human Jun 3725 P05412 JUN human S73 447943 VGLLkLAsPELERLI Jun X X 9164; 3270; 8752; 12714; 77955 +MAPK15 ERK7 Q8TD08 human Jun 3725 P05412 JUN human S63 447686 kNsDLLtsPDVGLLk Jun X X 5464; 9261; 2361; 97721; 91952 +MAPK15 ERK7 Q8TD08 human ERK7 225689 Q8TD08 MAPK15 human T175 459216 GPEDQAVtEyVATRW Pkinase X X +MAPK15 ERK7 Q8TD08 human ERK7 225689 Q8TD08 MAPK15 human T352 459220 ECGGSSGtSREKGPE X +Cdkl5 CDKL5 Q3UTQ8 mouse ARHGEF2 16800 Q60875 Arhgef2 mouse S122 4770069 TTRERPtsAIyPsDs X +Cdkl5 CDKL5 Q3UTQ8 mouse RP1 212307 Q8R001 Mapre2 mouse S222 476320 STPsRPssAKRASSS X X +Cdkl5 CDKL5 Q3UTQ8 mouse BPY2-IP1 270058 Q8C052 Map1s mouse S812 476391 GDRNRPLsARSEPAD X X +Cdkl5 CDKL5 Q3UTQ8 mouse BPY2-IP1 270058 Q8C052 Map1s mouse S786 27444827 KAPARPssAsAtPRA X X +Tyro3 Tyro3 P55144 mouse Tyro3 22174 P55144 Tyro3 mouse Y756 150180313 EEVYDLMyQCWSADP PK_Tyr_Ser-Thr X +Tyro3 Tyro3 P55144 mouse Tyro3 22174 P55144 Tyro3 mouse Y723 150180314 MTRGQTPyAGIENAE PK_Tyr_Ser-Thr X +AKT1 Akt1 P31749 human DIABLO 56616 Q9NR28 DIABLO human S67 29431803 AQkSEPHsLSSEALM Smac_DIABLO X X +AKT1 Akt1 P31749 human BEX1 501625 Q3MKQ2 Bex1 rat S105 14788300 KLRERQLsHSLRAVS BEX X X +AKT1 Akt1 P31749 human BIM 10018 O43521 BCL2L11 human S87 458219 FIFMRRSsLLSRSss X +AKT1 Akt1 P31749 human PKM 5315 P14618 PKM human S222 27110046 AVDLPAVsEkDIQDL PK X X +AKT1 Akt1 P31749 human TFEB 7942 P19484 TFEB human S467 4785142 KASsRRssFsMEEGD DUF3371 X X +AKT1 Akt1 P31749 human CTNND2 18163 O35927 Ctnnd2 mouse T454 480958 tGTFRtstAPssPGV X +AKT1 Akt1 P31749 human PLCG1 5335 P19174 PLCG1 human S1248 448665 HGrAREGsFEsRyQQ X 4510; 13349; 8713 +AKT1 Akt1 P31749 human CACNB2 116600 Q8VGC3 Cacnb2 rat S625 469619 KQRSRHKsKDRYCDK X +AKT1 Akt1 P31749 human MLK3 4296 Q16584 MAP3K11 human S674 448790 PGRERGEsPTtPPTP X X +AKT1 Akt1 P31749 human AS160 9882 O60343 TBC1D4 human S318 455925 EFRsRCssVtGVQRR PID X X 8619 +AKT1 Akt1 P31749 human RALGAPA2 57186 Q2PPJ7 RALGAPA2 human T715 460565 PMRFRsAttSGAPGV X +AKT1 Akt1 P31749 human SIK 150094 P57059 SIK1 human S435 7445611 VFRPRPVsPsSLLDT X X +AKT1 Akt1 P31749 human PHB 5245 P35232 PHB1 human T258 11139253 LSRSRNItyLPAGQs X +AKT1 Akt1 P31749 human PCK1 5105 P35558 PCK1 human S90 1868515110 RDVARIEsktVIVTQ PEPCK_N X X +AKT1 Akt1 P31749 human Nur77 79240 P22829 Nr4a1 rat S350 447942 GRRGRLPsKPKQPPD X X 5095 +AKT1 Akt1 P31749 human MST1 6789 Q13043 STK4 human T183 447925 DtMAkRNtVIGTPFW Pkinase X 3681; 49332 +AKT1 Akt1 P31749 human AMPKA1 5562 Q13131 PRKAA1 human S494 4717473 GtAtPQRsGsVsNyR AdenylateSensor X +AKT1 Akt1 P31749 human Merlin 4771 P35240 NF2 human S315 487469 MRRRKADsLEVQQMk FERM_C X +AKT1 Akt1 P31749 human acinus 305884 E9PST5 Acin1 rat S1180 456759 GPRSRSRsRDRRRKE RSB_motif X +AKT1 Akt1 P31749 human TOPBP1 11073 Q92547 TOPBP1 human S1159 472408 EERARLAsNLQWPSC X X +AKT1 Akt1 P31749 human TWIST1 7291 Q15672 TWIST1 human T121 38546302 NVRERQRtQsLNEAF HLH X X +AKT1 Akt1 P31749 human BACH2 12014 P97303 Bach2 mouse S520 470117 EtRTRtsssCssYsY X +AKT1 Akt1 P31749 human NFkB-p65 309165 Q7TQN4 Rela rat S535 447800 sGDEDFSsIADMDFS X 4887; 3036; 3031; 4886; 3033; 4025; 5733; 13346; 76778; 31553; 80477; 73992; 87672; 83962 +AKT1 Akt1 P31749 human NHE1 6548 P19634 SLC9A1 human S703 448347 MsRARIGsDPLAyEP X +AKT1 Akt1 P31749 human APS 114203 Q9Z200 Sh2b2 rat S588 456846 SARSRSNsTEHLLEA X X +AKT1 Akt1 P31749 human EGFR 1956 P00533 EGFR human S229 18944906 rCrGKSPsDCCHNQC Furin-like X X +AKT1 Akt1 P31749 human TBC1D1 57915 Q60949 Tbc1d1 mouse S700 2228807 KKLHssssVPNFLKF X 6929 +AKT1 Akt1 P31749 human CABLES1 91768 Q8TDN4 CABLES1 human T415 3207279 AFGARRNtIDstSsF X X +AKT1 Akt1 P31749 human p21Cip1 12575 P39689 Cdkn1a mouse T140 447837 QGRKRRQtsLTDFYH X +AKT1 Akt1 P31749 human p21Cip1 1026 P38936 CDKN1A human S146 447836 GRkRRQtsMTDFyHs X X +AKT1 Akt1 P31749 human Btk 695 Q06187 BTK human S51 28710300 FERGRRGsKKGsIDV PH X +AKT1 Akt1 P31749 human MITF 4286 O75030 MITF human S516 450265 KtssRRssMSMEETE DUF3371 X X +AKT1 Akt1 P31749 human IRAK1 3654 P51617 IRAK1 human T100 447720 LRARDIItAWHPPAP Death X +AKT1 Akt1 P31749 human PPP1CA 5499 P62136 PPP1CA human T320 448686 NPGGRPItPPRNsAK X 2581 +AKT1 Akt1 P31749 human PANK4 55229 Q9NVE7 PANK4 human T406 478688 AQRARsGtFDLLEMD X X +AKT1 Akt1 P31749 human CK1D 64462 Q06486 Csnk1d rat S370 483997 MERERKVsMRLHRGA X +AKT1 Akt1 P31749 human CSK 12988 P41241 Csk mouse S284 23096469 YLRSRGRsVLGGDCL PK_Tyr_Ser-Thr X +AKT1 Akt1 P31749 human SKI 6497 P12755 SKI human T458 11279400 QPRKRKLtVDTPGAP X X +AKT1 Akt1 P31749 human CARD11 84433 Q9BXL7 CARD11 human S652 457639 LERPFRPsVtsVGHV X 5189 +AKT1 Akt1 P31749 human TWIST1 7291 Q15672 TWIST1 human S42 14821304 GGRkRRSsRRsAGGG X X +AKT1 Akt1 P31749 human MST1 6789 Q13043 STK4 human T120 11496001 IIRLRNktLTEDEIA Pkinase X X +AKT1 Akt1 P31749 human FOXO4 4303 P98177 FOXO4 human S262 448517 TFRPRSssNAsSVsT X X +AKT1 Akt1 P31749 human RARA 5914 P10276 RARA human S96 465508 FVCQDKSsGYHYGVS zf-C4 X X +AKT1 Akt1 P31749 human PRPK 112858 Q96S44 TP53RK human S250 1981300 RLRGRKRsMVG____ X X +AKT1 Akt1 P31749 human K19 3880 P08727 KRT19 human S35 449970 GVAFrAPsIHGGsGG X X +AKT1 Akt1 P31749 human TBC1D1 57915 Q60949 Tbc1d1 mouse S231 2103609 RPMRKsFsQPGLRSL X +AKT1 Akt1 P31749 human 14-3-3 zeta 7534 P63104 YWHAZ human S58 449833 VVGARRssWRVVssI 14-3-3 X X 52631 +AKT1 Akt1 P31749 human CBY1 25776 Q9Y3M2 CBY1 human S20 2850009 TPPRKsAsLSNLHsL Chibby X +AKT1 Akt1 P31749 human CELF1 10658 Q92879 CELF1 human S28 3347300 GQVPrtWsEkDLREL RRM_1 X +AKT1 Akt1 P31749 human ER-beta 13983 O08537 Esr2 mouse S236 473056 VRRQRSAsEQVHCLN X +AKT1 Akt1 P31749 human PDCD4 27250 Q53EL6 PDCD4 human S67 458381 kRRLRKNssRDsGrG X X +AKT1 Akt1 P31749 human Sin1 227743 Q8BKH7 Mapkap1 mouse T86 3253548 GIRRRSNtAQRLERL SIN1 X 14716 +AKT1 Akt1 P31749 human p57Kip2 1028 P49918 CDKN1C human T310 450869 GVGsVEQtPRKRLR_ X X 2558 +AKT1 Akt1 P31749 human PHF20 51230 Q9BVI0 PHF20 human S265 15413296 RKRGRPPsIAPTAVD DUF3776 X +AKT1 Akt1 P31749 human eNOS 397557 Q7YSG7 NOS3 pig S1179 447884 TSRIRtQsFSLQERH X +AKT1 Akt1 P31749 human HSF1 3297 Q00613 HSF1 human S230 448072 PkYSRQFsLEHVHGS X X +AKT1 Akt1 P31749 human BMI1 648 P35226 BMI1 human S316 6150348 ANRPRKssVNGSSAT X X +AKT1 Akt1 P31749 human CLK2 1196 P49760 CLK2 human S34 15339201 HKRRRSRsWSSSSDR X X +AKT1 Akt1 P31749 human mTOR 2475 P42345 MTOR human S2448 447578 RsRtRtDsysAGQsV X X 2971; 2976; 5536; 54932 +AKT1 Akt1 P31749 human PYGO2 90780 Q9BRQ0 PYGO2 human S48 5965932 PEKKRRKsNtQGPAY X X +AKT1 Akt1 P31749 human FOXG1 15228 Q60987 Foxg1 mouse T271 482881 KLRRRSTtSRAKLAF X X +AKT1 Akt1 P31749 human ACLY 47 P53396 ACLY human S455 448631 PAPsRtAsFsEsRAD X 4331 +AKT1 Akt1 P31749 human PFKFB2 5208 O60825 PFKFB2 human S466 448460 PVRMRRNsFtPLssS X X +AKT1 Akt1 P31749 human FOXO1A 84482 G3V7R4 Foxo1 rat S313 449113 TFRPRTSsNAsTIsG X 2486 +AKT1 Akt1 P31749 human SHP-1 15170 P29351 Ptpn6 mouse T394 23144271 TAEYkLRtLQISPLD Y_phosphatase X +AKT1 Akt1 P31749 human NuaK1 9891 O60285 NUAK1 human S600 448726 PARQRIRsCVsAENF X X +AKT1 Akt1 P31749 human AurB 9212 Q96GD4 AURKB human T73 23085287 DILTRHFtIDDFEIG X X +AKT1 Akt1 P31749 human ADAR 103 P55265 ADAR human T1033 1868546602 RLGERLRtMSCSDKI A_deamin X X +AKT1 Akt1 P31749 human INVS 27130 Q9Y283 INVS human T866 55578723 ARRLEtstLSEDFQV X X +AKT1 Akt1 P31749 human HSF1 3297 Q00613 HSF1 human T527 1876167504 PPKAkDPtVS_____ Vert_HS_TF X +AKT1 Akt1 P31749 human DEPDC5 9681 O75140 DEPDC5 human S1530 3845300 QQRRRRNstSSTNQN DEPDC5_CTD X +AKT1 Akt1 P31749 human p27Kip1 1027 P46527 CDKN1B human T157 448645 GIRkrPAtDDSSTQN X X +AKT1 Akt1 P31749 human SFRS3 6428 P84103 SRSF3 human S128 6421243 FsRsRsRsLsRDRRR X +AKT1 Akt1 P31749 human MST2 6788 Q13188 STK3 human T384 3195191 GtMKRNAtsPQVQRP X X +AKT1 Akt1 P31749 human BRCA1 672 P38398 BRCA1 human S694 4787521 QTSKRHDsDTFPELk X X +AKT1 Akt1 P31749 human MLL4 iso3 8085 O14686-3 KMT2D human S1331 1217705 RGRARLKsTASSIET X +AKT1 Akt1 P31749 human PIKFYVE iso1 18711 Q9Z1T6-1 Pikfyve mouse S105 14881303 EELHRRSsVLENTLP X +AKT1 Akt1 P31749 human CLOCK 12753 O08785 Clock mouse S845 23094535 LPRHRtDsLTDPSKV X X +AKT1 Akt1 P31749 human SUMO1 7341 P63165 SUMO1 human T76 15178384 QrIADNHtPkELGME Rad60-SLD X X +AKT1 Akt1 P31749 human BRF1 677 Q07352 ZFP36L1 human S92 470147 RFRDRsFsEGGERLL Tis11B_N X X +AKT1 Akt1 P31749 human RNF11 26994 Q9Y3C5 RNF11 human T135 2893400 DWLMRSFtCPSCMEP zf-RING_2 X +AKT1 Akt1 P31749 human ULK1 22241 O70405 Ulk1 mouse S774 4699305 STRTRMFsVGsSSsL X +AKT1 Akt1 P31749 human SFRS3 6428 P84103 SRSF3 human S130 6421240 RsRsRsLsRDRRRER X +AKT1 Akt1 P31749 human FLNC 2318 Q14315 FLNC human S2233 467899 LGRERLGsFGsItRQ Filamin X +AKT1 Akt1 P31749 human CENTB1 9744 Q15027 ACAP1 human S554 458238 sIRPRPGsLRSkPEP X X +AKT1 Akt1 P31749 human PHF20 51230 Q9BVI0 PHF20 human S291 23303200 ELRRRKIsKGCEVPL X X +AKT1 Akt1 P31749 human USP4 7375 Q13107 USP4 human S445 5204831 NHRLRNDsVIVDTFH UCH X X +AKT1 Akt1 P31749 human PRSS15 9361 P36776 LONP1 human S181 1869121003 NESDVVEsLDEIyHT LON_substr_bdg X X +AKT1 Akt1 P31749 human NMDAR2C 24411 Q00961 Grin2c rat S1083 7979604 GPRPRHAsLPSSVAE X X +AKT1 Akt1 P31749 human SP1 6667 P08047 SP1 human S42 3180261 FsQARSSsTGsSSSt X X +AKT1 Akt1 P31749 human AML3 860 Q13950 RUNX2 human S196 27728401 GRSGRGKsFtLtITV Runt X +AKT1 Akt1 P31749 human p57Kip2 1028 P49918 CDKN1C human S282 9318134 FFAkRKRsAPEKSSG X X +AKT1 Akt1 P31749 human NQO1 1728 P15559 NQO1 human T128 1868914500 FIGEFAytyAAMyDk Flavodoxin_2 X X +AKT1 Akt1 P31749 human TSC2 24855 P49816 Tsc2 rat S1130 448499 GARDRVRsMsGGHGL X +AKT1 Akt1 P31749 human FOXO4 4303 P98177 FOXO4 human T32 455572 QsRPRsCtWPLPRPE X X 2599 +AKT1 Akt1 P31749 human eNOS 287024 P29473 NOS3 cow S617 448656 SYKIRFNsVSCSDPL Flavodoxin_1 X +AKT1 Akt1 P31749 human Mad1 4084 Q05195 MXD1 human S145 2807903 IERIRMDsIGSTVSS X X +AKT1 Akt1 P31749 human cytohesin 3 19159 O08967 Cyth3 mouse S155 25585001 ALRQFLWsFRLPGEA Sec7 X X +AKT1 Akt1 P31749 human beclin 1 8678 Q14457 BECN1 human S295 27156801 FRLGRLPsVPVEWNE APG6 X X +AKT1 Akt1 P31749 human RBM8A 9939 Q9Y5S9 RBM8A human S168 456535 GGRRRsRsPDRRRR_ X +AKT1 Akt1 P31749 human YB-1 4904 P67809 YBX1 human S102 455636 NPRKyLrsVGDGEtV CSD X X 2900 +AKT1 Akt1 P31749 human MDM2 4193 Q00987 MDM2 human S186 448131 RQRkRHksDsIsLsF X X +AKT1 Akt1 P31749 human SOX2 6657 P48431 SOX2 human T116 17490601 KYRPRRktktLMkKD SOXp X X +AKT1 Akt1 P31749 human AMPKA1 5562 Q13131 PRKAA1 human S496 450431 AtPQRsGsVsNyRSC AdenylateSensor X 4185; 4184; 2537 +AKT1 Akt1 P31749 human JARID1A 5927 P29375 KDM5A human S1255 56630502 CLTERAMsWQDRARQ X +AKT1 Akt1 P31749 human GATA2 2624 P23769 GATA2 human S401 455583 QTRNRKMsNKSKKSK X +AKT1 Akt1 P31749 human CCNF 899 P41002 CCNF human S577 234613503 TKRKRENsLQEDRGS X X +AKT1 Akt1 P31749 human FAK 5747 Q05397 PTK2 human S695 25291278 EERMRMEsRRQAtVs X X +AKT1 Akt1 P31749 human ADRB2 154 P07550 ADRB2 human S346 447911 LLCLRRssLKAyGNG X X +AKT1 Akt1 P31749 human acinus 305884 E9PST5 Acin1 rat S1329 456760 HSRSRsRsTPVRDRG X +AKT1 Akt1 P31749 human USP14 9097 P54578 USP14 human S432 31083558 THQGRSSsSGHyVSW UCH X X +AKT1 Akt1 P31749 human GR 2908 P04150 NR3C1 human S134 3178932 ANLNRstsVPENPkS GCR X X 85060 +AKT1 Akt1 P31749 human PKM 5315 P14618 PKM human S97 27110058 NVrtAtEsFAsDPIL PK X +AKT1 Akt1 P31749 human CTNNB1 12387 Q02248 Ctnnb1 mouse S552 472273 QDTQRRtsMGGtQQQ X X 9566; 5651 +AKT1 Akt1 P31749 human HES5 388585 Q5TA89 HES5 human S35 1867750500 RRDRINssIEQLKLL HLH X +AKT1 Akt1 P31749 human PDCD4 27250 Q53EL6 PDCD4 human S457 458382 RGRKRFVsEGDGGRL X X +AKT1 Akt1 P31749 human RPL13 6137 P26373 RPL13 human S106 480036 DPrRRNkstEsLQAN Ribosomal_L13e X +AKT1 Akt1 P31749 human VCP 7415 P55072 VCP human S352 457556 AAtNRPNsIDPALRR AAA X X +AKT1 Akt1 P31749 human CBP 1387 Q92793 CREBBP human T1871 474502 LMRRRMAtMNtRNVP X X +AKT1 Akt1 P31749 human AML3 860 Q13950 RUNX2 human T198 27728402 SGRGKsFtLtITVFT Runt X +AKT1 Akt1 P31749 human ZNF322A 79692 Q6U7Q0 ZNF322 human S224 114810402 EKSYRHRsAFIVHKR zf-C2H2 X X +AKT1 Akt1 P31749 human COPS6 10980 Q7L5N1 COPS6 human S60 27166600 DHWIRMRsQEGRPVQ JAB X X +AKT1 Akt1 P31749 human EDC3 80153 Q96F86 EDC3 human S161 1211074 sFRRRHNsWssssRH Edc3_linker X +AKT1 Akt1 P31749 human eNOS 24600 Q62600 Nos3 rat S1176 447884 TSRIRtQsFsLQERQ X 9570 +AKT1 Akt1 P31749 human AMPKA1 65248 P54645 Prkaa1 rat S496 450431 AtPQRSGsISNYRSC AdenylateSensor X 4185; 4184; 2537 +AKT1 Akt1 P31749 human DNAJC5 79130 P60905 Dnajc5 rat S10 448129 DQRQRsLsTsGEsLY X X +AKT1 Akt1 P31749 human PIK3R6 146850 Q5UE93 PIK3R6 human T607 10799542 SHRPREVtVsLRAtG PI3K_1B_p101 X +AKT1 Akt1 P31749 human GSK3A 606496 Q2NL51 Gsk3a mouse S21 448584 sGRARtssFAEPGGG X 9337; 9316; 9331; 9327; 8452; 8566 +AKT1 Akt1 P31749 human ITCH 83737 Q96J02 ITCH human S257 83110609 PsRPPRPsRPPPPTP X X +AKT1 Akt1 P31749 human PANK2 80025 Q9BZ23 PANK2 human S189 478697 TRRDRLGsysGPtsV X X +AKT1 Akt1 P31749 human TKT 7086 P29401 TKT human T382 34711200 GCATRNRtVPFCsTF Transket_pyr X +AKT1 Akt1 P31749 human FANCA 2175 O15360 FANCA human S1149 9802800 CLRSRDPsLMVDFIL X +AKT1 Akt1 P31749 human CDCA7 83879 Q9BWT1 CDCA7 human T163 4774845 SRRPRRRtFPGVASR X X +AKT1 Akt1 P31749 human HIST1H2BJ 8970 P06899 H2BC11 human S36 23113177 RKRSRkEsysIyVyk Histone X +AKT1 Akt1 P31749 human BAD 12015 Q61337 Bad mouse S112 447860 ETRsRHssyPAGtEE Bcl-2_BAD X 9291; 5284; 9296; 5193; 11865; 94223 +AKT1 Akt1 P31749 human TRF1 7013 P54274 TERF1 human T358 12115364 KKESRRAtESRIPVS X X +AKT1 Akt1 P31749 human p300 2033 Q09472 EP300 human S1834 447591 MLRRRMAsMQRTGVV X X +AKT1 Akt1 P31749 human THOC4 10189 Q86V81 ALYREF human T219 4614100 GGGtrRGtRGGARGR FoP_duplication X X +AKT1 Akt1 P31749 human BAP37 11331 Q99623 PHB2 human S91 22342307 RARPRkIssPTGSkD Band_7 X X +AKT1 Akt1 P31749 human METTL1 4234 Q9UBP6 METTL1 human S27 3627513 YYRQrAHsNPMADHT X X +AKT1 Akt1 P31749 human Bcl-10 8915 O95999 BCL10 human S231 469573 PLRsRtVsRQ_____ X +AKT1 Akt1 P31749 human CREB iso1 81646 P15337-1 Creb1 rat S133 448228 EILsRRPsYRkILND pKID X X 9187; 9196; 9198; 4095; 14228; 14001; 39561; 80120; 44864; 54960; 95995 +AKT1 Akt1 P31749 human GJA1 2697 P17302 GJA1 human S373 459209 RAssRAssRPRPDDL X X +AKT1 Akt1 P31749 human MDM2 17246 P23804 Mdm2 mouse S163 448130 SSRRRsIsEtEENTD X 3521 +AKT1 Akt1 P31749 human RAF1 5894 P04049 RAF1 human S259 447741 sQRQRststPNVHMV X 9421; 20011 +AKT1 Akt1 P31749 human lamin A/C 16905 P48678 Lmna mouse S404 478681 RsRGRAssHssQsQG X +AKT1 Akt1 P31749 human TSC2 7249 P49815 TSC2 human S981 454014 AFRCRSIsVSEHVVR X +AKT1 Akt1 P31749 human TSC2 24855 P49816 Tsc2 rat T1466 448546 GLRPRGYtISDSAPS X 3617; 3611 +AKT1 Akt1 P31749 human FOXO1A 2308 Q12778 FOXO1 human S256 448075 sPrRrAAsMDNNskF X X 9461; 84192 +AKT1 Akt1 P31749 human SSH1 54434 Q8WYL5 SSH1 human T826 35524905 AGLVRKHtKELERLK X X +AKT1 Akt1 P31749 human IKKA 1147 O15111 CHUK human T23 447780 EMRERLGtGGFGNVC Pkinase X X +AKT1 Akt1 P31749 human SH3RF1 59009 Q69ZI1 Sh3rf1 mouse S304 482847 KNTRKRHsFTSLTMA X +AKT1 Akt1 P31749 human CABLES1 91768 Q8TDN4 CABLES1 human T309 4270180 APLRRCRtLsGsPRP X X +AKT1 Akt1 P31749 human INVS 27130 Q9Y283 INVS human T864 55578722 SGARRLEtstLSEDF X X +AKT1 Akt1 P31749 human ephexin-1 25791 Q8N5V2 NGEF human S18 34499273 KTRRKsAsDQWNTDN X +AKT1 Akt1 P31749 human TRF1 7013 P54274 TERF1 human T273 6417401 sKRTRtItSQDKPSG X X +AKT1 Akt1 P31749 human GOLGA3 269682 P55937 Golga3 mouse S174 487482 VKRHRERsSQPAtKM X +AKT1 Akt1 P31749 human CENTG1 iso2 116986 Q99490-2 AGAP2 human S472 477808 RNLARALsTDCTPSG X X +AKT1 Akt1 P31749 human SIRT6 51548 Q8N6T7 SIRT6 human S338 7916000 PKRERPtsPAPHRPP X X +AKT1 Akt1 P31749 human GSK3B 56637 Q9WV60 Gsk3b mouse S9 449111 SGRPRttsFAEsCKP X X 9336; 9331; 9327; 9323; 9322; 9325; 5558; 8566; 79774; 8466; 25462; 14026; 14332; 14310; 14630 +AKT1 Akt1 P31749 human BAP37 11331 Q99623 PHB2 human S176 31828200 TERAKDFsLILDDVA Band_7 X X +AKT1 Akt1 P31749 human ACLY 47 P53396 ACLY human T447 455371 NAsGststPAPsRtA X +AKT1 Akt1 P31749 human MST1 6789 Q13043 STK4 human T387 450050 tMKRRDEtMQPAKPs X X +AKT1 Akt1 P31749 human AS160 9882 O60343 TBC1D4 human S570 455923 AKRsLtssLENIFsr X +AKT1 Akt1 P31749 human YAP1 10413 P46937 YAP1 human S127 448847 PQHVRAHssPAsLQL X X 4911; 13008; 92367; 57706 +AKT1 Akt1 P31749 human NBA1 29086 Q9NWV8 BABAM1 human S29 479974 EPRPRtRsNPEGAED X X 12110 +AKT1 Akt1 P31749 human RED1 104 P78563 ADARB1 human T553 31884906 LQGERLLtMSCSDKI A_deamin X X +AKT1 Akt1 P31749 human TBC1D1 23216 Q86TI0 TBC1D1 human T596 1247778 AFRRRANtLsHFPIE X +AKT1 Akt1 P31749 human VCP 7415 P55072 VCP human S746 457557 AMRFARRsVsDNDIr Vps4_C X X +AKT1 Akt1 P31749 human ACLY 47 P53396 ACLY human S451 455372 ststPAPsRtAsFsE X +AKT1 Akt1 P31749 human MKK4 6416 P45985 MAP2K4 human S80 447655 IERLRtHsIESSGkL X X 9155 +AKT1 Akt1 P31749 human p27Kip1 12576 P46414 Cdkn1b mouse S10 447874 NVRVsNGsPsLERMD X +AKT1 Akt1 P31749 human TIFA 92610 Q96CG3 TIFA human T9 50409900 tSFEDADtEEtVTCL X +AKT1 Akt1 P31749 human p21Cip1 114851 Q64315 Cdkn1a rat S146 447836 GRKRRQtsLTDFYHS X +AKT1 Akt1 P31749 human TERT 7015 O14746 TERT human S824 11418801 AVRIRGKsYVQCQGI RVT_1 X +AKT1 Akt1 P31749 human Merlin 4771 P35240 NF2 human S518 448282 DTDMKRLsMEIEKEK ERM_C X 9163; 13281 +AKT1 Akt1 P31749 human RARG iso2 19411 P18911-2 Rarg mouse S379 1869601000 ITDLRGIsTKGAERA Hormone_recep X +AKT1 Akt1 P31749 human TBC1D1 57915 Q60949 Tbc1d1 mouse S660 2228809 PRLNPSAssPNFFKY X 6928 +AKT1 Akt1 P31749 human EIF4B 75705 Q8BGD9 Eif4b mouse S422 451290 RERsRtGsEssQtGA X 3591 +AKT1 Akt1 P31749 human p21Cip1 12575 P39689 Cdkn1a mouse S141 447836 GRKRRQtsLTDFYHS X +AKT1 Akt1 P31749 human RARG 5916 P13631 RARG human S371 62884000 YARRRRPsQPYMFPR Hormone_recep X +AKT1 Akt1 P31749 human AR 367 P10275 AR human S215 448577 SGRAREAsGAPtsSK Androgen_recep X X +AKT1 Akt1 P31749 human DLC1 10395 Q96QB1 DLC1 human S766 458383 VTRTRsLsACNKRVG X X +AKT1 Akt1 P31749 human TBC1D1 57915 Q60949 Tbc1d1 mouse T590 1247778 AFRRRANtLsHFPVE X +AKT1 Akt1 P31749 human PFKFB3 5209 Q16875 PFKFB3 human S461 448801 NPLMRRNsVtPLAsP X X +AKT1 Akt1 P31749 human UBC9 7329 P63279 UBE2I human T35 18914511 PTKNPDGtMNLMNWE UQ_con X X +AKT1 Akt1 P31749 human p21Cip1 1026 P38936 CDKN1A human T145 447837 QGRkRRQtsMTDFyH X X +AKT1 Akt1 P31749 human EphA2 1969 P29317 EPHA2 human S897 1244153 RVsIRLPstsGsEGV X 16662; 6347 +AKT1 Akt1 P31749 human MDM2 4193 Q00987 MDM2 human S188 453413 RkRHksDsIsLsFDE X X +AKT1 Akt1 P31749 human FAK 5747 Q05397 PTK2 human T700 485788 MEsRRQAtVsWDsGG X X +AKT1 Akt1 P31749 human RPS3A 6189 P61247 RPS3A human T10 31828206 VGKNKRLtKGGKKGA X +AKT1 Akt1 P31749 human CFLAR 8837 O15519 CFLAR human S273 7590800 LLRDTFTsLGYEVQK Peptidase_C14 X +AKT1 Akt1 P31749 human H2B 3018 P33778 H2BC3 human S36 449903 RKRsRkEsysIyVyk Histone X +AKT1 Akt1 P31749 human FOXO1A 2308 Q12778 FOXO1 human T24 448560 LPRPRsCtWPLPRPE X X 2599; 9464 +AKT1 Akt1 P31749 human DNMT1 1786 P26358 DNMT1 human S143 3189394 RtPRRsksDGEAkPE X X +AKT1 Akt1 P31749 human nNOS 18125 Q9Z0J4 Nos1 mouse S1412 449830 TNRLRSEsIAFIEES X +AKT1 Akt1 P31749 human SCYL1 57410 Q96KG9 SCYL1 human T469 33402213 sTRHRVLtSAFSRAT X X +AKT1 Akt1 P31749 human cytohesin 2 9266 Q99418 CYTH2 human T276 30306600 LGGGRVKtWKRRWFI PH X +AKT1 Akt1 P31749 human EYA1 2138 Q99502 EYA1 human S299 41156500 SDRLRRGsDGKsRGR X +AKT1 Akt1 P31749 human TAL1 6886 P17542 TAL1 human T90 457536 EARHRVPttELCRPP X X +AKT1 Akt1 P31749 human BAD 572 Q92934 BAD human S99 447862 PFrGrsRsAPPNLWA Bcl-2_BAD X X 9295; 5286; 4366 +AKT1 Akt1 P31749 human PFKFB2 5208 O60825 PFKFB2 human S483 452046 IRRPRNysVGsRPLK X X 13064 +AKT1 Akt1 P31749 human NIBAN1 116496 Q9BZQ8 NIBAN1 human S602 467580 AsPARRAsAILPGVL X X +AKT1 Akt1 P31749 human CENTG1 iso2 116986 Q99490-2 AGAP2 human S629 4719772 THLSRVRsLDLDDWP ArfGap X X +AKT1 Akt1 P31749 human hnRNP A1 3178 P09651 HNRNPA1 human S199 451555 sQrGrsGsGNFGGGr X X +AKT1 Akt1 P31749 human CS 12974 Q9CZU6 Cs mouse S225 4774521 RNLYREGssIGAIDs Citrate_synt X +AKT1 Akt1 P31749 human SMAD3 4088 P84022 SMAD3 human T179 451177 PQSNIPEtPPPGYLS X +AKT1 Akt1 P31749 human PTP1B 5770 P18031 PTPN1 human S50 447811 RNRyRDVsPFDHsRI Y_phosphatase X X +AKT1 Akt1 P31749 human Akt1 207 P31749 AKT1 human S246 460649 LSRERVFsEDRARFY Pkinase X +AKT1 Akt1 P31749 human NCL 4691 P19338 NCL human T641 21697920 EIDGNkVtLDWAkPK RRM_1 X +AKT1 Akt1 P31749 human RPL7A 6130 P62424 RPL7A human T106 31828203 AHkYRPEtkQEKKQR X +AKT1 Akt1 P31749 human p47phox 653361 P14598 NCF1 human S304 449406 GAPPRRssIRNAHsI NECFESHC X +AKT1 Akt1 P31749 human TFEB 21425 Q9R210 Tfeb mouse S466 4785142 KAssRRssFsMEEGD DUF3371 X +AKT1 Akt1 P31749 human Nur77 3164 P22736 NR4A1 human S351 447942 GRRGRLPsKPKQPPD X X 5095 +AKT1 Akt1 P31749 human Huntingtin 3064 P42858 HTT human S419 448106 GGRsRsGsIVELIAG X X +AKT1 Akt1 P31749 human USP8 84092 Q80U87 Usp8 mouse T907 475072 TCRRRSRtFEAFMYL UCH X +AKT1 Akt1 P31749 human VCP 7415 P55072 VCP human S748 457558 RFARRsVsDNDIrky Vps4_C X X +AKT1 Akt1 P31749 human FBXW7 55294 Q969H0 FBXW7 human S227 17792400 QQRRRITsVQPPTGL X +AKT1 Akt1 P31749 human Ron 4486 Q04912 MST1R human S1394 450270 VRRPRPLsEPPRPT_ X X +AKT1 Akt1 P31749 human ENaC-alpha 25122 P37089 Scnn1a rat S621 454020 RFRsRYWsPGRGARG X +AKT1 Akt1 P31749 human VDAC2 7417 P45880 VDAC2 human S48 25316247 DVKtksCsGVEFSts Porin_3 X +AKT1 Akt1 P31749 human RAC1 5879 P63000 RAC1 human S71 447994 yDRLRPLsYPQTDVF Ras X 2461 +AKT1 Akt1 P31749 human GSK3A 2931 P49840 GSK3A human S21 448584 sGrARtssFAEPGGG X 9337; 9316; 9331; 5090; 9327; 8452; 8566 +AKT1 Akt1 P31749 human FOXO4 54601 Q9WVH3 Foxo4 mouse S197 448516 APRRRAAsMDSSSKL X 9471 +AKT1 Akt1 P31749 human WHSC1 7468 O96028 NSD2 human S172 478693 ARRNRKRsIKyDsLL X X +AKT1 Akt1 P31749 human HSP27 3315 P04792 HSPB1 human S82 448403 RALsRQLssGVsEIr X X 2406; 2401; 9709; 11892; 64293 +AKT1 Akt1 P31749 human NHE3 100009430 P26432 NHE-3 rabbit S515 31839901 NFDRRFLsKLLMRQs X X +AKT1 Akt1 P31749 human ATASE 5471 Q06203 PPAT human T397 1868225800 DSIVRGNtIsPIIkL Pribosyltran X +AKT1 Akt1 P31749 human USP35 57558 Q9P2H5 USP35 human S613 3214749 CRRRRLGsVMRPTED UCH X +AKT1 Akt1 P31749 human TTC3 7267 P53804 TTC3 human S378 12473003 AYTPRsLsAPIFTTS X X +AKT1 Akt1 P31749 human PLD2 5338 O14939 PLD2 human T175 1993000 NyLNRLLtMSFyRNY PX X +AKT1 Akt1 P31749 human BMI1 12151 P25916 Bmi1 mouse S314 6150348 ASRPRKssLNGSSAT X +AKT1 Akt1 P31749 human MDM4 4194 O15151 MDM4 human S367 457676 PDCRRtIsAPVVRPk X X +AKT1 Akt1 P31749 human CARD11 84433 Q9BXL7 CARD11 human S558 4737145 MQPPRsRssIMsITA X +AKT1 Akt1 P31749 human ARHGAP22 58504 Q7Z5H3 ARHGAP22 human S16 22262003 ARRARsKsLVMGEQS X +AKT1 Akt1 P31749 human NHE1 6548 P19634 SLC9A1 human S648 3880766 KTRQRLRsYNRHtLV NEXCaM_BD X +AKT1 Akt1 P31749 human PIKFYVE iso1 18711 Q9Z1T6-1 Pikfyve mouse S318 457532 PARNRsAsITNLSLD X +AKT1 Akt1 P31749 human Btk 695 Q06187 BTK human T495 28710301 EMRHRFQtQQLLEMC PK_Tyr_Ser-Thr X +AKT1 Akt1 P31749 human eNOS 4846 P29474 NOS3 human S615 448656 SYKIRFNsISCSDPL Flavodoxin_1 X +AKT1 Akt1 P31749 human HK2 3099 P52789 HK2 human T473 28704601 QHRARQktLEHLQLS Hexokinase_1 X +AKT1 Akt1 P31749 human THOC4 10189 Q86V81 ALYREF human S34 4614101 RGRGrAGsQGGrGGG X +AKT1 Akt1 P31749 human SKP2 6502 Q13309 SKP2 human S72 480507 PPRkRLkskGsDkDF X +AKT1 Akt1 P31749 human Akt1 207 P31749 AKT1 human T72 460648 tERPRPNtFIIRCLQ PH X +AKT1 Akt1 P31749 human JARID1A 5927 P29375 KDM5A human S287 56630503 RQRKGtLsVNFVDLY X +AKT1 Akt1 P31749 human TSC2 7249 P49815 TSC2 human T1462 448546 GLrPrGytISDsAPs X X 3617; 3611 +AKT1 Akt1 P31749 human TRBP 6895 Q15633 TARBP2 human S283 27457469 ILSLRsCsLGsLGAL X +AKT1 Akt1 P31749 human PKM 5315 P14618 PKM human S37 476070 MCRLDIDsPPItARN X +AKT1 Akt1 P31749 human lamin A/C 4000 P02545 LMNA human S404 478681 RsRGRAssHssQtQG X X +AKT1 Akt1 P31749 human BRCA1 672 P38398 BRCA1 human T509 448039 LKRKRRPtsGLHPED X X +AKT1 Akt1 P31749 human CASP9 842 P55211 CASP9 human S196 448454 kLRRRFssLHFMVEV Peptidase_C14 X X +AKT1 Akt1 P31749 human girdin 55704 Q3V6T2 CCDC88A human S1417 456477 INRERQksLtLtPTR X X +AKT1 Akt1 P31749 human mTOR 2475 P42345 MTOR human T2446 450853 NKRsRtRtDsysAGQ X +AKT1 Akt1 P31749 human ERR3 26381 P62509 Esrrg mouse S179 36400701 ITKRRRKsCQACRFM zf-C4 X +AKT1 Akt1 P31749 human FLI 2314 Q13045 FLII human S436 470489 RLRRRKDsAQDDQAK X +AKT1 Akt1 P31749 human NHE1 6548 P19634 SLC9A1 human S796 460570 QRIQRCLsDPGPHPE X +AKT1 Akt1 P31749 human ZRANB1 54764 Q9UGI0 ZRANB1 human S78 1105513501 SARPRVksSYSMENA X X +AKT1 Akt1 P31749 human ASK1 4217 Q99683 MAP3K5 human S83 447735 ATRGRGssVGGGSrR X X 3761 +AKT1 Akt1 P31749 human HTRA2 27429 O43464 HTRA2 human S212 477180 RVRVRLLsGDTYEAV Trypsin_2; Peptidase_M50 X X +AKT1 Akt1 P31749 human NDRG2 57447 Q9UN36 NDRG2 human T348 451009 GNRsRsRtLsQssEs X +AKT1 Akt1 P31749 human Bcl-10 8915 O95999 BCL10 human S218 469572 EEGTCANsSEMFLPL X +AKT1 Akt1 P31749 human USP33 23032 Q8TEY7 USP33 human T185 1883930900 ELRARGLtGLKNIGN X +AKT1 Akt1 P31749 human DTNBP1 94245 Q91WZ8 Dtnbp1 mouse S11 480124 TLRERLLsVQQDFTS X X +AKT1 Akt1 P31749 human DLC1 58834 Q63744 Dlc1 rat S330 458383 VTRTRSLsTCNKRVG X X +AKT1 Akt1 P31749 human PFKFB2 287019 P26285 PFKFB2 cow S484 452046 IRRPRNYsVGSRPLQ X +AKT1 Akt1 P31749 human METTL1 17299 Q9Z120 Mettl1 mouse S21 3627513 YYRQRAHsNPMADHT X +AKT1 Akt1 P31749 human eNOS 4846 P29474 NOS3 human S1177 447884 TSRIRtQsFsLQERQ X X 9571; 9570 +AKT1 Akt1 P31749 human CREB 1385 P16220 CREB1 human S119 448228 EILsRRPsyRkILND pKID X 9187; 9196; 9198; 4095; 14228; 14001; 39561; 80120; 44864; 54960; 95995 +AKT1 Akt1 P31749 human hnRNP E1 23983 P60335 Pcbp1 mouse S43 13258708 VKRIREEsGARINIs KH_1 X +AKT1 Akt1 P31749 human N-CoR1 9611 O75376 NCOR1 human S1450 1210494 tVRSRHtsVVsSGPs X X +AKT1 Akt1 P31749 human RAB3IP 117177 Q96QF0 RAB3IP human S165 472425 LSRLRsPsVLEVREK X X +AKT1 Akt1 P31749 human PCGF2 7703 P35227 PCGF2 human T334 34606690 TSRGRKMtVNGAPVP X X +AKT1 Akt1 P31749 human ITGB3 3690 P05106 ITGB3 human T779 470104 LyKEAtstFTNItyR Integrin_b_cyt X +AKT1 Akt1 P31749 human LBR G1N806 LBR turkey S82 14575430 RSRsRsRsRsPGRPA X +AKT1 Akt1 P31749 human FOXO3A 294515 D3ZBQ1 Foxo3 rat S252 449108 APRRRAVsMDNSNkY X 9466; 13129 +AKT1 Akt1 P31749 human WT1 iso7 7490 P19544-7 WT1 human S67 56653434 GRRsRGAsGsEPQQM X X +AKT1 Akt1 P31749 human XIAP 331 P98170 XIAP human S87 450336 VGRHRKVsPNCRFIN BIR X X +AKT1 Akt1 P31749 human TSC2 7249 P49815 TSC2 human S939 448501 sFRARstsLNERPKs X 3615 +AKT1 Akt1 P31749 human SP1 6667 P08047 SP1 human S698 5262507 CPkRFMRsDHLskHI zf-C2H2 X X +AKT1 Akt1 P31749 human MLK3 4296 Q16584 MAP3K11 human T477 36324901 HVRRRRGtFKRSKLR X X +AKT1 Akt1 P31749 human GSK3B 2932 P49841 GSK3B human S9 449111 SGRPRttsFAEsCkP X X 9336; 9331; 9327; 9323; 9322; 9325; 5558; 8566; 79774; 8466; 25462; 14026; 14332; 14310; 14630 +AKT1 Akt1 P31749 human RPS3 6188 P23396 RPS3 human T70 15113600 GrrIrELtAVVQkRF KH_2 X X +AKT1 Akt1 P31749 human Kaiso 10009 Q86T24 ZBTB33 human T606 34353150 yLSDRSStIPAMkDD X +AKT1 Akt1 P31749 human ZRANB1 54764 Q9UGI0 ZRANB1 human T117 1105513502 QRRTRsPtESPQSSG X X +AKT1 Akt1 P31749 human NDRG2 57447 Q9UN36 NDRG2 human S332 451010 LsRsRtAsLtsAAsV X +AKT1 Akt1 P31749 human RPS3A 6189 P61247 RPS3A human S112 31828205 LTRDkMCsMVKKWQT Ribosomal_S3Ae X +AKT1 Akt1 P31749 human RANBP3 8498 Q9H6Z4 RANBP3 human S126 460735 VKRERtssLtQFPPs X X 9380 +AKT1 Akt1 P31749 human AS160 9882 O60343 TBC1D4 human S751 455924 EGRKRtsstCsNEsL X +AKT1 Akt1 P31749 human Merlin 4771 P35240 NF2 human T230 487468 AIRNKKGtELLLGVD FERM_C X +AKT1 Akt1 P31749 human TBC1D1 57915 Q60949 Tbc1d1 mouse T499 2228808 NRAKRsLtEsLEsIL X +AKT1 Akt1 P31749 human EZH2 2146 Q15910 EZH2 human S21 457606 CWRKRVKsEyMRLRQ X X +AKT1 Akt1 P31749 human IGPR-1 126259 Q96BF3 TMIGD2 human S220 14160579 GKDQRGQsIyStSFP X X +AKT1 Akt1 P31749 human AR 367 P10275 AR human S792 448415 CVRMRHLsQEFGWLQ Hormone_recep X X +AKT1 Akt1 P31749 human ephexin-1 25791 Q8N5V2 NGEF human S16 34501054 LEKTRRKsAsDQWNT X +AKT1 Akt1 P31749 human MDM2 4193 Q00987 MDM2 human S166 448130 SsRRRAIsEtEENsD X X 3521 +AKT1 Akt1 P31749 human cytohesin 3 19159 O08967 Cyth3 mouse T280 25585002 KLGGRVKtWKRRWFI PH X X +AKT1 Akt1 P31749 human PRAS40 84335 Q96B36 AKT1S1 human T246 470067 LPRPRLNtsDFQkLK PRAS X X 2640; 2997; 32263; 13175; 60202 +AKT1 Akt1 P31749 human AML3 860 Q13950 RUNX2 human T200 27728400 RGKsFtLtITVFTNP Runt X +AKT1 Akt1 P31749 human FOXO4 54601 Q9WVH3 Foxo4 mouse T32 455572 QSRPRSCtWPLPRPD X +AKT1 Akt1 P31749 human ARHGAP19 84986 Q14CB8 ARHGAP19 human S422 3196670 QkRARsRsFsGLIkR X +AKT1 Akt1 P31749 human IWS1 55677 Q96ST2 IWS1 human T721 1851496 QRRRMNstGGQtPRR X +AKT1 Akt1 P31749 human SOX2 20674 P48432 Sox2 mouse T118 17490601 kYRPRRktkTLMkKD SOXp X X +AKT1 Akt1 P31749 human TIE1 21846 Q06806 Tie1 mouse T794 50596802 LHRRRTFtYQSGSGE X X +AKT1 Akt1 P31749 human FBXO31 79791 Q5XUX0 FBXO31 human S33 485583 AETAAADsEPDtDPE X +AKT1 Akt1 P31749 human SLC7A11 23657 Q9UPY5 SLC7A11 human S26 470841 NVNGRLPsLGNkEPP X X +AKT1 Akt1 P31749 human FOXO3A 2309 O43524 FOXO3 human T32 448602 QsRPRsCtWPLQRPE X X 2599; 9464 +AKT1 Akt1 P31749 human CYCS 54205 P99999 CYCS human Y47 3416311 ktGQAPGysytAANk Cytochrom_C X X +AKT1 Akt1 P31749 human beclin 1 8678 Q14457 BECN1 human S234 27156802 AQyQREysEFkRQQL APG6_N X +AKT1 Akt1 P31749 human BAX 581 Q07812 BAX human S184 451017 VAGVLTAsLtIWKKM TM X +AKT1 Akt1 P31749 human RENT1 5976 Q92900 UPF1 human T151 50788283 FCNGRGNtSGSHIVN UPF1_Zn_bind X X +AKT1 Akt1 P31749 human AS160 9882 O60343 TBC1D4 human S341 455922 QPRRRHAsAPsHVQP PID X +AKT1 Akt1 P31749 human p27Kip1 1027 P46527 CDKN1B human T198 448781 PGLRRRQt_______ X X +AKT1 Akt1 P31749 human MYST3 7994 Q92794 KAT6A human T369 19008950 RGRKRKItLSSQSAS X X +AKT1 Akt1 P31749 human JARID1A 5927 P29375 KDM5A human T285 56630501 QMRQRKGtLsVNFVD X +AKT1 Akt1 P31749 human ACOT4 122970 Q8N9L9 ACOT4 human S392 1871177703 GGEPRAHskAQEDAW BAAT_C X X +AKT1 Akt1 P31749 human SIK 150094 P57059 SIK1 human T182 456034 kSGEPLStWCGSPPY Pkinase X +AKT1 Akt1 P31749 human TSC2 24855 P49816 Tsc2 rat S939 448501 KFRARSTsLNERPKS X 3615 +AKT1 Akt1 P31749 human acinus 22985 Q9UKV3 ACIN1 human S1180 456759 GPRsRsRsRDRRRKE RSB_motif X +AKT1 Akt1 P31749 human YB-1 4904 P67809 YBX1 human S209 7998039 YGrrPQysNPPVQGE X +AKT1 Akt1 P31749 human p300 328572 B2RWS6 Ep300 mouse S1733 1295500 PGDSRRLsIQRCIQS X X +AKT1 Akt1 P31749 human PRSS15 9361 P36776 LONP1 human S173 1869121004 VFLKRDDsNESDVVE LON_substr_bdg X X +AKT1 Akt1 P31749 human FOXO4 4303 P98177 FOXO4 human S197 448516 APRRRAAsMDsSSKL X X 9471 +AKT1 Akt1 P31749 human lamin A/C 60374 P48679 Lmna rat S301 480106 QSRIRIDsLSAQLSQ Filament X +AKT1 Akt1 P31749 human ZNF322A 79692 Q6U7Q0 ZNF322 human T262 10990183 IVHQRVHtGEkPYKC X X +AKT1 Akt1 P31749 human MST2 6788 Q13188 STK3 human T117 12615900 IIRLRNktLIEDEIA Pkinase X X +AKT1 Akt1 P31749 human peripherin 19132 P15331 Prph mouse S66 483953 sssArLGsFRAPRAG Filament_head X X +AKT1 Akt1 P31749 human ER-alpha 2099 P03372 ESR1 human S167 448102 GGRERLAsTNDkGSM Oest_recep X X 64508; 42101 +AKT1 Akt1 P31749 human FOXO1A 2308 Q12778 FOXO1 human S319 449113 TFRPRtssNAstIsG X X 2486 +AKT1 Akt1 P31749 human GABRB2 25451 P63138 Gabrb2 rat S434 449329 SRLRRRAsQLKITIP Neur_chan_memb X X +AKT1 Akt1 P31749 human MASTL 84930 Q96GX5 MASTL human T299 1269647500 QsRKRLAtSSAsSQS X +AKT1 Akt1 P31749 human TXNIP 56338 Q8BG60 Txnip mouse S309 277409200 GLSSRTSsMASRTSS X X +AKT1 Akt1 P31749 human CDK2 1017 P24941 CDK2 human T39 2712201 LkKIRLDtETEGVPs Pkinase X X +AKT1 Akt1 P31749 human FOXG1 2290 P55316 FOXG1 human T279 482881 KLRRRsttsRAKLAF X +AKT1 Akt1 P31749 human TBC1D1 57915 Q60949 Tbc1d1 mouse S621 2228806 RKLMRYHsVstETPH X +AKT1 Akt1 P31749 human BRAF 673 P15056 BRAF human S365 450243 GQRDRsssAPNVHIN X +AKT1 Akt1 P31749 human CARHSP1 23589 Q9Y2V2 CARHSP1 human S52 453062 tRRtrtFsAtVRAsQ X X +AKT1 Akt1 P31749 human NHERF 9368 O14745 NHERF1 human T156 3864004 ELRPRLCtMKKGPsG PDZ X X +AKT1 Akt1 P31749 human arfaptin 2 23647 P53365 ARFIP2 human S260 455884 GTRGRLEsAQATFQA Arfaptin X X +AKT1 Akt1 P31749 human PAPD4 167153 Q6PIY7 TENT2 human S116 50785745 LsGERRYsMPPLFHT X +AKT1 Akt1 P31749 human TBC1D7 51256 Q9P0N9 TBC1D7 human S124 15415675 GkLPRsPsFPLEPDD X X +AKT1 Akt1 P31749 human S6 6194 P62753 RPS6 human S236 448093 AKRRRLssLRAstsK X 5006; 4856; 4857; 4858; 4851; 4803; 2211; 3945; 3985; 5316; 4854; 8520; 48319; 40643; 9865; 38573; 14733; 27036; 34411; 62016; 62788; 81736; 97935; 99457; 15448 +AKT1 Akt1 P31749 human Chk1 1111 O14757 CHEK1 human S280 447831 AKRPRVtsGGVsEsP X X 2347 +AKT1 Akt1 P31749 human LBR G1N806 LBR turkey S80 14575427 SRRSRsRsRsRsPGR X +AKT1 Akt1 P31749 human SH3BP4 23677 Q9P0V3 SH3BP4 human S246 3214461 FRsKRsYsLsELsVL X +AKT1 Akt1 P31749 human GAB2 9846 Q9UQC2 GAB2 human S159 448382 LLRERKSsAPSHsSQ X X 3884 +AKT1 Akt1 P31749 human DRP1 10059 O00429 DNM1L human S616 454690 PIPIMPAsPQKGHAV X 3455; 4494; 63940 +AKT1 Akt1 P31749 human BRF1 677 Q07352 ZFP36L1 human S203 470146 PRLQHsFsFAGFPSA X +AKT1 Akt1 P31749 human ataxin-1 6310 P54253 ATXN1 human S775 449110 AtRKRRWsAPESRKL X X +AKT1 Akt1 P31749 human LARP6 55323 Q9BRS8 LARP6 human S451 485240 QEKsPGtsPLLsRKM X X +AKT1 Akt1 P31749 human ATP1A1 24211 P06685 Atp1a1 rat S943 451649 ICKTRRNsVFQQGMK Cation_ATPase_C X +AKT1 Akt1 P31749 human GJA1 24392 P08050 Gja1 rat S369 459208 RPssRAssRAssRPR X +AKT1 Akt1 P31749 human ASK1 26408 O35099 Map3k5 mouse S90 447735 ATRGRGNsGSGGGRR X +AKT1 Akt1 P31749 human DENND1A 227801 Q8K382 Dennd1a mouse S536 484447 PYRtLKEsDsAEGDE X +AKT1 Akt1 P31749 human PKM 5315 P14618 PKM human S202 15721963 tEVENGGsLGskkGV PK X +AKT1 Akt1 P31749 human WNK1 65125 Q9H4A3 WNK1 human T60 450948 EYRRRRHtMDKDSrG X X 4946 +AKT1 Akt1 P31749 human LTB4R2 56413 Q9NPC1 LTB4R2 human T324 12267086 GGRSREGtMELRTTP TM X X +AKT1 Akt1 P31749 human RSK2 6197 P51812 RPS6KA3 human T115 1880515604 KVRDRVRtKMERDIL X X +AKT1 Akt1 P31749 human PDE3A 54611 Q9Z0X4 Pde3a mouse S291 471416 WKRRRRsssVVAGEM X +AKT1 Akt1 P31749 human FLNA 2316 P21333 FLNA human S2152 451357 tRRRRAPsVANVGsH Filamin X 4761 +AKT1 Akt1 P31749 human AS160 9882 O60343 TBC1D4 human T642 455921 QFRRRAHtFsHPPss X X 4288; 8881 +AKT1 Akt1 P31749 human INVS 27130 Q9Y283 INVS human S865 55578721 GARRLEtstLSEDFQ X X +AKT1 Akt1 P31749 human Wee1 7465 P30291 WEE1 human S642 455381 KKMNRSVsLtIy___ X 4910 +AKT1 Akt1 P31749 human BRAF 673 P15056 BRAF human S429 447803 PQRERKsssssEDRN X +AKT1 Akt1 P31749 human Merlin 4771 P35240 NF2 human S10 1720901 GAIASRMsFSsLkRK X X +AKT1 Akt1 P31749 human CCT2 10576 P78371 CCT2 human S260 472352 GsRVRVDstAkVAEI Cpn60_TCP1 X X +AKT1 Akt1 P31749 human Cot 1326 P41279 MAP3K8 human S400 447712 EDQPRCQsLDSALLE X 4491 +AKT1 Akt1 P31749 human DLC1 10395 Q96QB1 DLC1 human S735 15499997 MVRKRsVsNstQtSS X X +AKT1 Akt1 P31749 human JARID1A 5927 P29375 KDM5A human T1225 56630500 SRRPRLEtILSLLVS X +AKT1 Akt1 P31749 human DJ-1 11315 Q99497 PARK7 human T125 1869992402 GFGSKVTtHPLAkDk DJ-1_PfpI X +AKT1 Akt1 P31749 human SP1 6667 P08047 SP1 human T679 25312143 ELQRHKRtHtGEkkF zf-C2H2 X X +AKT1 Akt1 P31749 human Vimentin 7431 P08670 VIM human S39 451766 ttstrtysLGsALrP Filament_head X X 13614 +AKT1 Akt1 P31749 human CARD11 84433 Q9BXL7 CARD11 human S644 457638 NLMFRKFsLERPFRP X +AKT1 Akt1 P31749 human TSC2 24855 P49816 Tsc2 rat S1132 448500 RDRVRsMsGGHGLRV X +AKT1 Akt1 P31749 human PANK2 80025 Q9BZ23 PANK2 human S169 478728 PLRRRAssAsVPAVG X X +AKT1 Akt1 P31749 human UBE2S 27338 Q16763 UBE2S human T152 58109405 AARARLLtEIHGGAG UQ_con X X +AKT1 Akt1 P31749 human AS160 9882 O60343 TBC1D4 human T568 486326 NKAKRsLtssLENIF X +AKT1 Akt1 P31749 human p47phox 653361 P14598 NCF1 human S328 449404 QDAYRRNsVRFLQQR NECFESHC X +AKT1 Akt1 P31749 human SFRS3 6428 P84103 SRSF3 human S122 6421062 SPRRRsFsRsRsRsL X +AKT1 Akt1 P31749 human SSB 6741 P05455 SSB human T389 477729 VKRAREEtDkEEPAS X X +AKT1 Akt1 P31749 human ZNF322A 79692 Q6U7Q0 ZNF322 human T150 1869121002 LVHQRSHtGEKPYLC X X +AKT1 Akt1 P31749 human Bcl-3 602 P20749 BCL3 human S41 27444668 kRPLRAPsPEPAAPR X +AKT1 Akt1 P31749 human AS160 9882 O60343 TBC1D4 human S588 455920 RMRGRLGsVDsFERs X X 8730 +AKT1 Akt1 P31749 human HSP70 3303 P0DMV8 HSPA1B human S631 483567 AQGPkGGsGsGPtIE X X +AKT1 Akt1 P31749 human eNOS 287024 P29473 NOS3 cow S1179 447884 TSRIRtQsFsLQERH X X 9570 +AKT1 Akt1 P31749 human DENND1A 227801 Q8K382 Dennd1a mouse S538 484448 RtLKEsDsAEGDETE X +AKT1 Akt1 P31749 human E2A iso2 21423 P15806-2 Tcf3 mouse S527 483180 VPRtRtsstDEVLsL X +AKT1 Akt1 P31749 human p27Kip1 1027 P46527 CDKN1B human S10 447874 NVRVSNGsPsLErMD X X +AKT1 Akt1 P31749 human CCNF 899 P41002 CCNF human T31 234613504 RRRPRNLtILSLPED X X +AKT1 Akt1 P31749 human Sin1 79109 Q9BPZ7 MAPKAP1 human T86 3253548 GIRRRsNtAQRLERL SIN1 X 14716 +AKT1 Akt1 P31749 human MVD 4597 P53602 MVD human S96 476192 LARKRRNsRDGDPLP X +AKT1 Akt1 P31749 human SFRS3 6428 P84103 SRSF3 human S138 470451 RDRRRERsLsRERNH X +AKT1 Akt1 P31749 human CBX3 11335 Q13185 CBX3 human T89 31828201 AGkEkDGtKRksLsD X +AKT1 Akt1 P31749 human p21Cip1 114851 Q64315 Cdkn1a rat T145 447837 QGRKRRQtsLTDFYH X +AKT1 Akt1 P31749 human DLC1 10395 Q96QB1 DLC1 human S1004 34490415 RHRLRWHsFQSSHRP X X +AKT1 Akt1 P31749 human TKT 7086 P29401 TKT human S387 18503161 NRtVPFCsTFAAFFT Transket_pyr X +AKT1 Akt1 P31749 human JARID1A 5927 P29375 KDM5A human S225 36123496 TRRVkTQsESGDVSR X +AKT1 Akt1 P31749 human Zyxin 7791 Q15942 ZYX human S142 460644 PQPREKVssIDLEId X X 4863; 8467 +AKT1 Akt1 P31749 human FAF1 11124 Q9UNN5 FAF1 human S582 480070 kLRIRtPsGEFLERR UBX X X +AKT1 Akt1 P31749 human CBX3 11335 Q13185 CBX3 human T55 31828202 FLkWkGFtDADNtWE Chromo X +AKT1 Akt1 P31749 human RALGAPA2 57186 Q2PPJ7 RALGAPA2 human S486 485552 SsWGRTYsFtSAMsR X +AKT1 Akt1 P31749 human AS160 9882 O60343 TBC1D4 human S666 486327 GRAQGVRsPLLRQSS X +AKT1 Akt1 P31749 human RGC32 iso2 28984 Q9H4X1-2 RGCC human S45 6370305 ERMKRRSsAsVSDSS RGCC X +AKT1 Akt1 P31749 human Akt1 11651 P31750 Akt1 mouse S473 447855 RPHFPQFsysAsGtA Pkinase_C X 9271; 3787; 4060; 4051; 5102; 4058; 2336; 2337; 4075; 4070; 5012; 4071; 92982; 5315; 9563; 9018; 12694; 52240; 11962; 15116; 88106; 26580; 68035; 31957; 23430; 20235 +AKT1 Akt1 P31749 human TBC1D1 57915 Q60949 Tbc1d1 mouse T253 2228805 DASLRSStFssFDND X +AKT1 Akt1 P31749 human NPM1 4869 P06748 NPM1 human S48 14577038 QLsLrTVsLGAGAkD Nucleoplasmin X X +AKT1 Akt1 P31749 human KHSRP 8570 Q92945 KHSRP human S193 473552 GLPERsVsLtGAPEs KH_1 X +AKT1 Akt1 P31749 human PIP5K1C 23396 O60331 PIP5K1C human S555 1855423 RYRRRtQssGQDGRP X X +AKT1 Akt1 P31749 human CLK2 1196 P49760 CLK2 human T127 15339202 RRRRRSRtFSRSSSQ X X +AKT1 Akt1 P31749 human HES5 388585 Q5TA89 HES5 human S34 1867750501 MRRDRINssIEQLKL HLH X +AKT1 Akt1 P31749 human FOXO3A 294515 D3ZBQ1 Foxo3 rat T32 448602 QSRPRSCtWPLQRPE X 9464 +AKT1 Akt1 P31749 human NFAT90 3609 Q12906 ILF3 human S647 3496801 rGrGRGGsIRGRGRG X X +AKT1 Akt1 P31749 human SYTL1 84958 Q8IYJ3 SYTL1 human S241 456480 RMLsSSSsVSSLNSS X +AKT1 Akt1 P31749 human PGC-1 alpha 19017 O70343 Ppargc1a mouse S570 2045307 RMRSRsRsFsRHRSC X +AKT1 Akt1 P31749 human HuR 1994 Q15717 ELAVL1 human S100 474553 VSYARPSsEVIkDAN X X +AKT1 Akt1 P31749 human HSF1 3297 Q00613 HSF1 human S326 455484 ssVDtLLsPTALIDs Vert_HS_TF X X +AKT1 Akt1 P31749 human CTNNB1 1499 P35222 CTNNB1 human S552 472273 QDtQRRtsMGGtQQQ X X 9566; 5651 +AKT1 Akt1 P31749 human TWIST1 7291 Q15672 TWIST1 human S123 14821303 RERQRtQsLNEAFAA HLH X X +AKT1 Akt1 P31749 human PACS2 23241 Q86VP3 PACS2 human S437 480160 GRRGRStsLKERQAA X +AKT1 Akt1 P31749 human TSPYL5 85453 Q86VY4 TSPYL5 human T120 3245189 SERLAADtVFVGTAG X +AKT1 Akt1 P31749 human TERT 7015 O14746 TERT human S227 11418800 GARRRGGsASRSLPL X X +AKT1 Akt1 P31749 human GOLGA3 269682 P55937 Golga3 mouse S385 478659 EVRsRRDsICssVSM X +AKT1 Akt1 P31749 human EDG-1 1901 P21453 S1PR1 human T236 447691 RTRSRRLtFRKNISK 7tm_1 X X +AKT1 Akt1 P31749 human FOXO3A 56484 Q9WVH4 Foxo3 mouse T32 448602 QSRPRSCtWPLQRPE X 9464 +AKT1 Akt1 P31749 human NHEJ1 79840 Q9H9Q4 NHEJ1 human T181 35499302 LIRDRLktEPFEENS X X +AKT1 Akt1 P31749 human PDE3A 54611 Q9Z0X4 Pde3a mouse S292 471417 KRRRRsssVVAGEMS X +AKT1 Akt1 P31749 human HK2 15277 O08528 Hk2 mouse T473 28704601 QHRARQKtLESLKLS Hexokinase_1 X X +AKT1 Akt1 P31749 human lamin A/C 4000 P02545 LMNA human S301 480106 QsRIRIDsLsAQLsQ Filament X +AKT1 Akt1 P31749 human lamin A/C 60374 P48679 Lmna rat S404 478681 RSRGRAssHssQSQG X +AKT1 Akt1 P31749 human PIKFYVE 200576 Q9Y2I7 PIKFYVE human S318 3216759 LsLDRsGsPMVPSyE X +AKT1 Akt1 P31749 human ATG4B 23192 Q9Y4P1 ATG4B human S34 4750282 WILGRKYsIFTEkDE X +AKT1 Akt1 P31749 human SFRS3 6428 P84103 SRSF3 human S140 470452 RRRERsLsRERNHKP X +AKT1 Akt1 P31749 human RICTOR 253260 Q6R327 RICTOR human T1135 458276 NRRIRtLtEPsVDFN RICTOR_phospho X 3806 +AKT1 Akt1 P31749 human FOXA2 3170 Q9Y261 FOXA2 human T156 4911901 KTYRRSYtHAKPPYS Forkhead_N X +AKT1 Akt1 P31749 human PERK 13666 Q9Z2B5 Eif2ak3 mouse T799 11073906 YTRSREGtSSSIVFE X +AKT1 Akt1 P31749 human palladin 23022 Q8WX93 PALLD human S1118 468361 VRRPRsRsRDsGDEN X X +AKT1 Akt1 P31749 human PIKFYVE 200576 Q9Y2I7 PIKFYVE human S307 457532 PARNRsAsItNLsLD X X +AKT1 Akt1 P31749 human SH3RF1 57630 Q7Z6J0 SH3RF1 human S304 482847 KNTKKRHsFtsLtMA X +AKT1 Akt1 P31749 human HJURP 55355 Q8NCD3 HJURP human S486 482923 GLEtRRLsLPssKAK X +AKT1 Akt1 P31749 human ZNF322A 79692 Q6U7Q0 ZNF322 human T234 1246856 IVHKRVHtGEkPYKC X X +AKT1 Akt1 P31749 human PFKFB2 287019 P26285 PFKFB2 cow S467 448460 PVRMRRNsFTPLSSS X +AKT1 Akt1 P31749 human p300 328572 B2RWS6 Ep300 mouse S1833 447591 MLRRRMAsMQRTGVA X X +AKT1 Akt1 P31749 human AML3 860 Q13950 RUNX2 human S28 3053615 PSTsRRFsPPSssLQ X +AKT1 Akt1 P31749 human PAPD4 167153 Q6PIY7 TENT2 human S110 31880251 VNQIVPLsGERRYsM X +AKT1 Akt1 P31749 human IRS1 3667 P35568 IRS1 human S629 478346 VPsGRKGsGDyMPMs X X +AKT1 Akt1 P31749 human NCL 4691 P19338 NCL human T707 21697921 HKPQGKKtKFE____ X +AKT1 Akt1 P31749 human GJA1 24392 P08050 Gja1 rat S373 459209 RAssRAssRPRPDDL X +AKT1 Akt1 P31749 human Myt1 Q95YJ1 Pkmyt1 starfish S75 449752 ESRPRAVsFRQSEPS X X +AKT1 Akt1 P31749 human PDHK1 5163 Q15118 PDK1 human T346 13831355 APRPRVEtsRAVPLA HATPase_c X +AKT1 Akt1 P31749 human RPS3A 6189 P61247 RPS3A human T88 31828204 FRkFkLItEDVQGkN Ribosomal_S3Ae X +AKT1 Akt1 P31749 human HIST2H3A/C/D 126961 Q71DI3 H3C14 human T45 18465115 PHryrPGtVALrEIR Histone X +AKT1 Akt1 P31749 human BAD 12015 Q61337 Bad mouse S136 447862 PFRGRsRsAPPNLWA Bcl-2_BAD X X 9295; 5286; 4366 +AKT1 Akt1 P31749 human GATSL3 652968 Q8WTX7 CASTOR1 human S14 25293269 EHRVRVLsVARPGLW Castor1_N X X +AKT1 Akt1 P31749 human FOXO3A 2309 O43524 FOXO3 human S253 449108 APRRRAVsMDNSNkY X X 9466; 13129 +AKT1 Akt1 P31749 human PAR-4 64513 Q62627 Pawr rat S249 456965 SRHNRDTsAPANFAS ATG16; DUF724; DUF4164 X X +AKT1 Akt1 P31749 human SRPK2 6733 P78362 SRPK2 human T492 483237 PSHDRSRtVsAsstG X X +AKT1 Akt1 P31749 human NMDAR2C 14813 Q01098 Grin2c mouse S1084 7979604 GPRPRHAsLPSSVAE X +AKT1 Akt1 P31749 human GATA1 2623 P15976 GATA1 human S310 451231 QtRNRKAsGkGkkkR X X +AKT1 Akt1 P31749 human HSF1 3297 Q00613 HSF1 human T142 449066 DsVTKLLtDVQLMKG X +AKT1 Akt1 P31749 human H3 8350 P68431 H3C1 human T45 455679 PHryrPGtVALrEIR Histone X X +AKT1 Akt1 P31749 human SSB 20823 P32067 Ssb mouse T301 452110 LLRNKKVtWkVLEGH RRM_3 X +AKT1 Akt1 P31749 human PHB 18673 P67778 Phb1 mouse T258 11139253 LSRSRNItyLPAGQs X +AKT1 Akt1 P31749 human GSK3A 50686 P18265 Gsk3a rat S21 448584 SGRARtssFAEPGGG X 9337; 9316; 9331; 9327; 8452; 8566 +AKT1 Akt1 P31749 human NLRP3 114548 Q96P20 NLRP3 human S5 38492201 ___MKMAsTRCKLAR X +AKT1 Akt1 P31749 human Kv11.1 iso5 3757 Q12809_VAR_014388 KCNH2 human T897 4839200 SFRRRtDtDtEQPGE X +AKT1 Akt1 P31749 human ER-alpha 2099 P03372 ESR1 human S305 448805 IkRSkkNsLALSLtA X +AKT1 Akt1 P31749 human CK2A1 1457 P68400 CSNK2A1 human T13 31012808 PsRARVytDVNtHRP X X +AKT1 Akt1 P31749 human NQO1 1728 P15559 NQO1 human S40 23255660 kGWEVVEsDLyAMNF Flavodoxin_2 X +AKT1 Akt1 P31749 human DOCK6 57572 Q96HP0 DOCK6 human S1194 27806316 GQRsRLAsMLDSDTE X X +AKT1 Akt1 P31749 human Huntingtin 15194 P42859 Htt mouse S398 448106 RGRGRsGsIVELLAG X +AKT1 Akt1 P31749 human K8 3856 P05787 KRT8 human S432 448540 sAyGGLtsPGLsysL X +AKT1 Akt1 P31749 human IWS1 55677 Q96ST2 IWS1 human S720 477902 PQRRRMNstGGQtPR X +AKT1 Akt1 P31749 human NHE1 24782 P26431 Slc9a1 rat S652 3880766 KTRQRLRsYNRHTLV NEXCaM_BD X X +AKT1 Akt1 P31749 human EPRS 2058 P07814 EPRS1 human S999 9720900 NQGGGLsssGAGEGQ X X +AKT1 Akt1 P31749 human FLCN 201163 Q8NFG4 FLCN human S62 3206874 NSRMRAHsPAEGAsV X X +AKT1 Akt1 P31749 human H2B2F 440689 Q5QNW6 H2BC18 human S36 1210846 RKRsRkEsysVyVyk Histone X +AKT1 Akt1 P31749 human EMSY 56946 Q7Z589 EMSY human S209 453526 RKRRRtNsssssPVV X X +AKT1 Akt1 P31749 human IP3R1 25262 P29994 Itpr1 rat S2682 458310 FPRMRAMsLVSSDSE X X +AKT1 Akt1 P31749 human SH3BP4 98402 Q921I6 Sh3bp4 mouse S245 3214461 FRsKRsYsLSELsVL X X +AKT1 Akt1 P31749 human USP10 9100 Q14694 USP10 human T674 10801134 VEIsRRVtLEkLPPV UCH X X +AKT1 Akt1 P31749 human PEA-15 8682 Q15121 PEA15 human S116 450281 kDIIRQPsEEEIIKL X X +AKT1 Akt1 P31749 human RSK2 6197 P51812 RPS6KA3 human S19 7445513 KMAVEsPsDSAENGQ X X +AKT1 Akt1 P31749 human GATA1 14460 P17679 Gata1 mouse S310 451231 QTRNRkAsGkGKKkR X +AKT1 Akt1 P31749 human DBNL 28988 Q9UJU6 DBNL human S269 467729 KQKERAMsttsIssP X +AKT1 Akt1 P31749 human DBNL 28988 Q9UJU6 DBNL human T291 476604 PFLQkQLtQPEtHFG X +AKT1 Akt1 P31749 human cGAS 214763 Q8C6L5 Cgas mouse S291 36128853 VEKEKPGsPAVTLLI Mab-21 X X +AKT1 Akt1 P31749 human MAZ 4150 P56270 MAZ human T385 449095 kDRLRAHtVRHEEKV X X +AKT1 Akt1 P31749 human TFE3 209446 Q64092 Tfe3 mouse S565 455896 KAssRRssFsMEEES DUF3371 X X +AKT1 Akt1 P31749 human PLB 64672 P61016 Pln rat S16 448114 RSAIRRAstIEMPQQ Phospholamban X 8496 +AKT1 Akt1 P31749 human HMOX1 3162 P09601 HMOX1 human S188 2897404 LYRSRMNsLEMtPAV Heme_oxygenase X X +AKT1 Akt1 P31749 human RPS3 27050 P62908 Rps3 mouse T70 15113600 GRRIRELtAVVQkRF KH_2 X +AKT1 Akt1 P31749 human TIAM1 7074 Q13009 TIAM1 human S231 468938 sTCQRANsLGDLYAQ X X +AKT1 Akt1 P31749 human IRE1 78943 Q9EQY0 Ern1 mouse S724 7161100 KLAVGRHsFSRRsGV Pkinase X X +AKT1 Akt1 P31749 human PDE3A 54611 Q9Z0X4 Pde3a mouse S290 471415 GWKRRRRsssVVAGE X +RET Ret P07949 human Ret 5979 P07949 RET human Y981 450703 DNCSEEMyRLMLQCW PK_Tyr_Ser-Thr X X +RET Ret P07949 human FAK 5747 Q05397 PTK2 human Y925 447966 DRsNDkVyENVtGLV Focal_AT X 3284 +RET Ret P07949 human Ret 5979 P07949 RET human Y1090 450704 TNTGFPRyPNDSVyA X +RET Ret P07949 human ATF-4 468 P18848 ATF4 human T107 40420006 LGIDDLEtMPDDLLt X X +RET Ret P07949 human FAK 5747 Q05397 PTK2 human Y577 447890 yMEDstyyKAsKGKL PK_Tyr_Ser-Thr X X 3281 +RET Ret P07949 human ATF-4 468 P18848 ATF4 human T115 40420008 MPDDLLttLDDtCDL X X +RET Ret P07949 human JNK2 5601 P45984 MAPK9 human Y185 447652 tNFMMtPyVVtRYYR Pkinase X +RET Ret P07949 human Ret 5979 P07949 RET human Y1096 449891 RyPNDSVyANWMLSP X +RET Ret P07949 human JNK1 5599 P45983 MAPK8 human Y185 447645 tsFMMtPyVVtRYYR Pkinase X 5136; 4668; 4671; 9257; 9255; 9251; 4306; 5755; 16014; 58328 +RET Ret P07949 human PIK3R1 5295 P27986 PIK3R1 human Y203 25693200 PVIPAAVySEMIsLA RhoGAP X +RET Ret P07949 human Ret 5979 P07949 RET human Y826 449893 SRKVGPGyLGSGGSR PK_Tyr_Ser-Thr X +RET Ret P07949 human Ret 5979 P07949 RET human Y1015 449894 MMVKRRDyLDLAAST X +RET Ret P07949 human PDK1 5170 O15530 PDPK1 human Y9 447696 ARTTSQLyDAVPIQS X +RET Ret P07949 human ATF-4 468 P18848 ATF4 human T114 40420007 tMPDDLLttLDDtCD X X +RET Ret P07949 human DOK1 1796 Q99704 DOK1 human Y398 448369 ARVkEEGyELPyNPA X +RET Ret P07949 human Ret 5979 P07949 RET human Y809 450701 LIVEyAKyGSLRGFL PK_Tyr_Ser-Thr X +RET Ret P07949 human FAK 5747 Q05397 PTK2 human Y861 447965 PIGNQHIyQPVGKPD X +RET Ret P07949 human ATF-4 468 P18848 ATF4 human T119 40420009 LLttLDDtCDLFAPL X X +RET Ret P07949 human Ret 5979 P07949 RET human Y1029 449895 TPSDSLIyDDGLSEE X +RET Ret P07949 human Ret 5979 P07949 RET human Y687 449892 AQAFPVsysSSGARR X +RET Ret P07949 human PLCG1 5335 P19174 PLCG1 human Y783 447667 EGRNPGFyVEANPMP X 2821; 14461; 14008; 25678; 88717 +RET Ret P07949 human ERK1 5595 P27361 MAPK3 human T202 447542 HDHtGFLtEyVAtRW Pkinase X 9106; 4370; 4374; 9101; 4375; 4376; 4377; 3510; 5726; 88569; 13214; 13148; 70235; 9488; 89967; 8544; 14196; 14227; 14095; 14474; 75165; 98168; 33370; 54240; 15892; 45899; 55088; 9524; 69217; 48735 +RET Ret P07949 human AFAP1L2 84632 Q8N4X5 AFAP1L2 human Y54 462131 SSSsDEEyIyMNKVt X +RET Ret P07949 human Akt1 207 P31749 AKT1 human Y315 448519 tFCGtPEyLAPEVLE Pkinase X X +RET Ret P07949 human Ret 5979 P07949 RET human Y806 450700 PLLLIVEyAKyGSLR PK_Tyr_Ser-Thr X +RET Ret P07949 human Ret 5979 P07949 RET human Y900 450702 FGLSRDVyEEDsyVK PK_Tyr_Ser-Thr X +RET Ret P07949 human ERK2 5594 P28482 MAPK1 human Y187 447594 HtGFLtEyVAtRWyr Pkinase X 9106; 4370; 4374; 9101; 4375; 4376; 4377; 3510; 5726; 88569; 13214; 13148; 70235; 9488; 89967; 8544; 14196; 14227; 14095; 14474; 75165; 98168; 33370; 54240; 15892; 45899; 55088; 9524; 69217; 48735 +RET Ret P07949 human Ret 5979 P07949 RET human Y905 447627 DVyEEDsyVKRsQGR PK_Tyr_Ser-Thr X X 3221 +RET Ret P07949 human FAK 5747 Q05397 PTK2 human Y576 447889 RyMEDstyyKAsKGK PK_Tyr_Ser-Thr X X 3281 +RET Ret P07949 human ERK1 5595 P27361 MAPK3 human Y204 447543 HtGFLtEyVAtRWyr Pkinase X X 9106; 4370; 4374; 9101; 4375; 4376; 4377; 3510; 5726; 88569; 13214; 13148; 70235; 9488; 89967; 8544; 14196; 14227; 14095; 14474; 75165; 98168; 33370; 54240; 15892; 45899; 55088; 9524; 69217; 48735 +RET Ret P07949 human Ret 5979 P07949 RET human Y1062 447625 TWIENkLyGMsDPNW X X +RET Ret P07949 human P38A 1432 Q16539 MAPK14 human Y182 447971 tDDEMtGyVAtRWYR Pkinase X 9211; 9215; 4551; 9216; 4552; 4631; 4511; 4092; 9219; 24678; 8632; 6908; 41768; 51255; 14594; 14598; 62979 +Tesk1 TESK1 Q63572 rat Destrin 11034 P60981 DSTN human S3 449754 _____MAsGVQVADE X X +Tesk1 TESK1 Q63572 rat TESK1 29460 Q63572 Tesk1 rat S215 452045 EPLAVVGsPYWMAPE PK_Tyr_Ser-Thr X +Tesk1 TESK1 Q63572 rat Cofilin-1 12631 P18760 Cfl1 mouse S3 448444 _____MAsGVAVsDG X 3313; 3311 +Tesk1 TESK1 Q63572 rat Cofilin-1 1072 P23528 CFL1 human S3 448444 _____MAsGVAVsDG X X 3313; 3311 +HIPK4 HIPK4 Q8NE63 human RIMBP3 239731 Q3V0F0 Rimbp3 mouse S15 1879727000 PLGGGRAsPKKPSsP X +HIPK4 HIPK4 Q8NE63 human RIMBP3 239731 Q3V0F0 Rimbp3 mouse S21 36704995 AsPKKPSsPGPAAAV X +HIPK4 HIPK4 Q8NE63 human RIMBP3 239731 Q3V0F0 Rimbp3 mouse S263 17545556 NTGVRVHsPNDLLPT X +HIPK4 HIPK4 Q8NE63 human RIMBP3 239731 Q3V0F0 Rimbp3 mouse S347 599813228 PCEASTSsPPGLDYQ X +Prkcz PKCZ P09217 rat PKCZ 25522 P09217 Prkcz rat T560 447572 TSEPVQLtPDDEDVI Pkinase_C X +Prkcz PKCZ P09217 rat ATP1A1 24211 P06685 Atp1a1 rat S16 449086 KyEPAAVsEHGDkks X 4020 +Prkcz PKCZ P09217 rat ATP1A1 24211 P06685 Atp1a1 rat S23 449087 sEHGDkkskkAKKER X 4006 +Prkcz PKCZ P09217 rat IRS1 25467 P35570 Irs1 rat S318 451399 MVGGkPGsFRVRAss X X 5610 +Prkcz PKCZ P09217 rat Akt1 24185 P47196 Akt1 rat T34 455493 FLLKNDGtFIGYKER PH X +Prkcb PKCB iso2 P68403-2 rat RKIP 29542 P31044 Pebp1 rat S153 448755 RGkFkVEsFRKKYHL PBP X +Prkcb PKCB iso2 P68403-2 rat GABRB3 24922 P63079 Gabrb3 rat S433 450246 THLRRRssQLKIKIP Neur_chan_memb X +Prkcb PKCB iso2 P68403-2 rat GABRB3 24922 P63079 Gabrb3 rat S432 450245 KTHLRRRssQLKIKI Neur_chan_memb X +Prkcb PKCB iso2 P68403-2 rat GABRB1 25450 P15431 Gabrb1 rat S434 450244 GRIRRRAsQLKVKIP Neur_chan_memb X +CDK5 CDK5 Q02399 cow PPP1CA 5499 P62136 PPP1CA human T320 448686 NPGGRPItPPRNsAK X 2581 +CDK5 CDK5 Q02399 cow SYN1 281510 P17599 SYN1 cow S553 448377 TRPPAsPsPQRQAGP X +CDK5 CDK5 Q02399 cow PPP1R1A 5502 Q13522 PPP1R1A human S67 447758 LKSTLAMsPRQRKKM DARPP-32 X +LYN LYN P07948 human Syk 20963 P48025 Syk mouse Y317 447658 STVSFNPyEPtGGPW X X 2715 +LYN LYN P07948 human NMT1 4836 P30419 NMT1 human Y180 10336300 YTLLNENyVEDDDNM NMT X +LYN LYN P07948 human Abl 25 P00519 ABL1 human Y393 450298 RLMtGDtytAHAGAk PK_Tyr_Ser-Thr X 2865 +LYN LYN P07948 human YY1 7528 P25490 YY1 human Y8 41608701 MASGDTLyIATDGSE X +LYN LYN P07948 human AKAP8 10270 O43823 AKAP8 human Y53 40420004 TTGATySyGPASWEA X +LYN LYN P07948 human GCET2 257144 Q8N6F7 GCSAM human Y106 463673 sGNsAEEyyENVPCk HGAL X +LYN LYN P07948 human ACLY 47 P53396 ACLY human Y682 450360 sRtTDGVyEGVAIGG Ligase_CoA X X +LYN LYN P07948 human RGS16 6004 O15492 RGS16 human Y177 448653 RFLkSPAyRDLAAQA RGS X +LYN LYN P07948 human Ig-alpha 12518 P11911 Cd79a mouse Y182 473649 DyEDENLyEGLNLDD ITAM X 14948; 5173; 14732; 29742; 52821; 17749 +LYN LYN P07948 human CD163L1 338056 P30205 CD163L1 cow Y1326 470034 DALAEAVyEELDYLL X +LYN LYN P07948 human SLC4A1 6521 P02730 SLC4A1 human Y21 457533 ENLEQEEyEDPDIPE X +LYN LYN P07948 human SLC4A1 6521 P02730 SLC4A1 human Y8 451570 MEELQDDyEDMMEEN X +LYN LYN P07948 human SHP-1 5777 P29350 PTPN6 human Y564 448912 sKHkEDVyENLHTkN X 8849 +LYN LYN P07948 human FCGR2A 2212 P12318 FCGR2A human Y304 449552 tDDDKNIyLTLPPND X +LYN LYN P07948 human ACLY 47 P53396 ACLY human Y131 450359 YATREGDyVLFHHEG X X +LYN LYN P07948 human CSF2RB 1439 P32927 CSF2RB human Y882 2358800 KALKQQDyLSLPPWE X +LYN LYN P07948 human FAM82A2 55177 Q96TC7 RMDN3 human Y176 19009800 DAESEGGytTANAEs X +LYN LYN P07948 human CSF2RB 1439 P32927 CSF2RB human Y822 450124 VLQQVGDyCFLPGLG X +LYN LYN P07948 human TIF1B 10155 Q13263 TRIM28 human Y517 464439 PGsTtEDyNLIVIER X +LYN LYN P07948 human CASP8 841 Q14790 CASP8 human Y380 460647 tDsEEQPyLEMDLSs Peptidase_C14 X +LYN LYN P07948 human Syk 6850 P43405 SYK human Y323 447658 sTVsFNPyEPELAPW X 2715 +LYN LYN P07948 human CSF2RB 1439 P32927 CSF2RB human Y466 3141903 ALRFCGIyGyRLRRk X +LYN LYN P07948 human CASP8 841 Q14790 CASP8 human Y448 1032277 TILTEVNyEVSNKDD Peptidase_C14 X +LYN LYN P07948 human CD19 930 P15391 CD19 human Y500 447638 TSLGsQsyEDMRGIL X X +LYN LYN P07948 human IRF5 3663 Q13568 IRF5 human Y335 25742049 QLQGQDLyAIRLCQC IRF-3 X +LYN LYN P07948 human LY96 23643 Q9Y6Y9 LY96 human Y131 21400400 IKFSKGKyKCVVEAI E1_DerP2_DerF2 X +LYN LYN P07948 human YY1 7528 P25490 YY1 human Y383 41608702 IHtGDrPyVCPFDGC zf-C2H2 X X +LYN LYN P07948 human Btk 12229 P35991 Btk mouse Y551 447486 RYVLDDEyTsSVGSK PK_Tyr_Ser-Thr X 69360; 18805; 64137; 16803 +LYN LYN P07948 human SLC4A1 6521 P02730 SLC4A1 human Y359 455384 AKPDssFyKGLDLNG X X +LYN LYN P07948 human Abl 25 P00519 ABL1 human Y128 459259 SLEKHSWyHGPVSRN SH2 X +LYN LYN P07948 human AKAP8 10270 O43823 AKAP8 human Y154 476956 RPsySyDyEFDLGSD X +LYN LYN P07948 human BIM 12125 O54918 Bcl2l11 mouse Y161 810853200 GDEFNETyTRRVFAN Bclx_interact X +LYN LYN P07948 human p27Kip1 1027 P46527 CDKN1B human Y88 456818 kGsLPEFyyRPPRPP X +LYN LYN P07948 human FCGR2B 2213 P31994 FCGR2B human Y292 448507 GAENTITysLLMHPD X +LYN LYN P07948 human TIF1B 10155 Q13263 TRIM28 human Y449 3576406 PMEVQEGyGFGsGDD X +LYN LYN P07948 human AKAP8 10270 O43823 AKAP8 human Y539 40420000 IVkMLEkyLKGEDPF AKAP95 X +LYN LYN P07948 human PTEN 5728 P60484 PTEN human Y240 448316 RREDKFMyFEFPQPL PTEN_C2 X +LYN LYN P07948 human LAB 7462 Q9GZY6 LAT2 human Y95 455006 EDPASSRyQNFSkGs LAT2 X +LYN LYN P07948 human CBL 867 P22681 CBL human Y371 449753 TQEQyELyCEMGSTF X +LYN LYN P07948 human Abl 25 P00519 ABL1 human Y226 450303 KRNKPtVyGVsPNyD X 2868; 2861 +LYN LYN P07948 human LY96 23643 Q9Y6Y9 LY96 human Y22 21400401 FTEAQKQyWVCNSSD X +LYN LYN P07948 human Abl 25 P00519 ABL1 human Y115 450305 QGWVPsNyItPVNSL X +LYN LYN P07948 human GCET2 257144 Q8N6F7 GCSAM human Y128 463674 LGGTEtEySLLHMPS HGAL X X +LYN LYN P07948 human Syk 6850 P43405 SYK human Y348 447659 LPMDtEVyEsPyADP X +LYN LYN P07948 human PKCD 18753 P28867 Prkcd mouse Y565 447576 IRVDTPHyPRWITKE Pkinase X +LYN LYN P07948 human GCET2 257144 Q8N6F7 GCSAM human Y107 454098 GNsAEEyyENVPCkA HGAL X X +LYN LYN P07948 human IKKB 3551 O14920 IKBKB human Y188 449632 sFVGTLQyLAPELLE Pkinase X +LYN LYN P07948 human ACLY 47 P53396 ACLY human Y252 462909 EAyPEEAyIADLDAk Citrate_bind X X +LYN LYN P07948 human Abl 25 P00519 ABL1 human Y215 469589 GLITTLHyPAPKRNK X +LYN LYN P07948 human Abl 25 P00519 ABL1 human Y70 462900 PNLFVALyDFVAsGD SH3_1 X 3098 +LYN LYN P07948 human PEAK1 79834 Q9H792 PEAK1 human Y635 449709 IVINPNAyDNLAIyK X +LYN LYN P07948 human CDK4 1019 P11802 CDK4 human Y17 455500 AEIGVGAyGTVYkAR Pkinase X +LYN LYN P07948 human AKAP8 10270 O43823 AKAP8 human Y146 40420002 CLPEHNPyRPsySyD X +LYN LYN P07948 human AKAP8 10270 O43823 AKAP8 human Y170 15417596 NGsFGGQySECRDPA X +LYN LYN P07948 human Syk 6850 P43405 SYK human Y526 447662 LRADENyykAQtHGK PK_Tyr_Ser-Thr X 2711; 2710; 12967; 5514; 4349; 6485; 12081; 46994; 16859 +LYN LYN P07948 human SOCS1 8651 O15524 SOCS1 human Y80 1868450203 LLDACGFyWGPLSVH SH2 X +LYN LYN P07948 human LYN 4067 P07948 LYN human Y508 447624 ytAtEGQyQQQP___ X 2731 +LYN LYN P07948 human COX-2 5743 P35354 PTGS2 human Y120 34434400 PPTYNADyGYKSWEA X +LYN LYN P07948 human GLO1 2739 Q04760 GLO1 human Y136 463450 GIAVPDVysACkRFE Glyoxalase X +LYN LYN P07948 human LAB 7462 Q9GZY6 LAT2 human Y119 454710 DPIAMEyyNWGRFSk LAT2 X +LYN LYN P07948 human SLC4A1 6521 P02730 SLC4A1 human Y904 455304 EEEGRDEyDEVAMPV X X +LYN LYN P07948 human FCGR2C 9103 P31995 FCGR2C human Y310 449501 tDDDKNIyLTLPPND X +LYN LYN P07948 human Bcr 613 P11274 BCR human Y177 447792 ADAEKPFyVNVEFHH X 3901 +LYN LYN P07948 human ACLY 47 P53396 ACLY human Y659 55373280 yRPGsVAyVSRsGGM X X +LYN LYN P07948 human DBNL 13169 Q62418 Dbnl mouse Y340 450090 QTEEEPTyEVPPEQD X +LYN LYN P07948 human Btk 695 Q06187 BTK human Y223 447485 LKKVVALyDyMPMNA SH3_1 X 5082; 87141; 87457 +LYN LYN P07948 human AKAP8 10270 O43823 AKAP8 human Y51 40420005 SVTTGATySyGPASW X +LYN LYN P07948 human PKCD 18753 P28867 Prkcd mouse Y311 447573 TTEsVGIyQGFEKKP X 2055 +LYN LYN P07948 human IFITM3 66141 Q9CQW9 Ifitm3 mouse Y20 463584 SGGQPPNyERIkEEy X +LYN LYN P07948 human CD19 930 P15391 CD19 human Y531 447639 HEEDADsyENMDNPD X X 3571 +LYN LYN P07948 human Abl 25 P00519 ABL1 human Y139 456712 VSRNAAEyLLsSGIN SH2 X +LYN LYN P07948 human LAB 7462 Q9GZY6 LAT2 human Y110 454708 RHGsEEAyIDPIAME LAT2 X +LYN LYN P07948 human IRF5 3663 Q13568 IRF5 human Y313 57775901 PSDkQRFyTNQLLDV IRF-3 X +LYN LYN P07948 human LYN 4067 P07948 LYN human Y397 448695 RVIEDNEytAREGAk PK_Tyr_Ser-Thr X 2101; 6943; 59548; 70926; 78740; 94361; 17320 +LYN LYN P07948 human PKCD 18753 P28867 Prkcd mouse Y155 447575 IKQAKIHyIKNHEFI X +LYN LYN P07948 human AKAP8 10270 O43823 AKAP8 human Y152 7366805 PyRPsySyDyEFDLG X +LYN LYN P07948 human AKAP8 10270 O43823 AKAP8 human Y150 15407467 HNPyRPsySyDyEFD X +LYN LYN P07948 human Ig-beta 15985 P15530 Cd79b mouse Y195 459286 GMEEDHTyEGLNIDQ ITAM X +LYN LYN P07948 human GluR2 14800 P23819 Gria2 mouse Y876 452173 ykEGyNVyGIEsVKI X 4027; 3921 +LYN LYN P07948 human Syk 20963 P48025 Syk mouse Y519 447661 ALRADENyyKAQTHG PK_Tyr_Ser-Thr X 2711; 2710; 12967; 5514; 4349; 6485; 12081; 46994; 16859 +LYN LYN P07948 human AFAP1L1 106877 Q8BZI0 Afap1l1 mouse Y127 41691500 KPPPEDYyEEALPLG X +LYN LYN P07948 human SHP-1 5777 P29350 PTPN6 human Y536 448506 QkGQEsEyGNItyPP X X +LYN LYN P07948 human SLAM 6504 Q13291 SLAMF1 human Y327 447634 ETNSITVyASVTLPE X X +LYN LYN P07948 human GCET2 257144 Q8N6F7 GCSAM human Y86 449473 tysEELCytLINHRV HGAL X +LYN LYN P07948 human RGS16 6004 O15492 RGS16 human Y168 448652 TLMEKDSyPRFLkSP RGS X +LYN LYN P07948 human leupaxin 107321 Q99N69 Lpxn mouse Y72 449706 NIQEPNVysEVQEPK X +LYN LYN P07948 human SHP-1 15170 P29351 Ptpn6 mouse Y536 448506 QKGQEsEyGNItyPP X +LYN LYN P07948 human LYN 17096 P25911 Lyn mouse Y397 448695 RVIEDNEytAREGAK PK_Tyr_Ser-Thr X 2101; 6943; 59548; 70926; 78740; 94361; 17320 +LYN LYN P07948 human Abl 25 P00519 ABL1 human Y172 460505 LRyEGRVyHyRINTA SH2 X +LYN LYN P07948 human AKAP8 10270 O43823 AKAP8 human Y80 40420001 PAMHMASyGPEPCTD X +LYN LYN P07948 human LAB 7462 Q9GZY6 LAT2 human Y136 450963 EDDDANsyENVLICK LAT2 X +LYN LYN P07948 human PKCD 18753 P28867 Prkcd mouse Y52 447574 VQkKPTMyPEWKTTF X +LYN LYN P07948 human Syk 20963 P48025 Syk mouse Y520 447662 LRADENyyKAQTHGK PK_Tyr_Ser-Thr X 2711; 2710; 12967; 5514; 4349; 6485; 12081; 46994; 16859 +LYN LYN P07948 human LAB 7462 Q9GZY6 LAT2 human Y118 454709 IDPIAMEyyNWGRFS LAT2 X +LYN LYN P07948 human Syk 6850 P43405 SYK human Y352 447660 tEVyEsPyADPEEIR X 2701; 2717; 14791; 73382; 82975; 31754 +LYN LYN P07948 human BIM 12125 O54918 Bcl2l11 mouse Y92 56650528 LsRSSsGyFSFDTDR X X +LYN LYN P07948 human ACLY 47 P53396 ACLY human Y384 462910 VRrGGPNyQEGLrVM Citrate_bind X X +LYN LYN P07948 human ACLY 47 P53396 ACLY human Y227 1868989000 KVDATADyICkVkWG X X +LYN LYN P07948 human HS1 3059 P14317 HCLS1 human Y222 452057 MEAPttAykkTTPIE X +LYN LYN P07948 human Btk 695 Q06187 BTK human Y551 447486 RYVLDDEytsSVGSk PK_Tyr_Ser-Thr X 69360; 18805; 64137; 16803 +LYN LYN P07948 human DBNL 13169 Q62418 Dbnl mouse Y350 450091 PPEQDTLyEEPPLVQ X +LYN LYN P07948 human Abl 25 P00519 ABL1 human Y185 450304 TAsDGKLyVsSESRF SH2 X 3009 +LYN LYN P07948 human GCET2 257144 Q8N6F7 GCSAM human Y80 449472 QDNVDQtysEELCyt HGAL X +LYN LYN P07948 human Syk 6850 P43405 SYK human Y525 447661 ALRADENyykAQtHG PK_Tyr_Ser-Thr X 2711; 2710; 12967; 5514; 4349; 6485; 12081; 46994; 16859 +LYN LYN P07948 human IKKB 3551 O14920 IKBKB human Y199 449633 ELLEQQKyTVTVDYW Pkinase X +LYN LYN P07948 human CSF2RB 1439 P32927 CSF2RB human Y468 3141904 RFCGIyGyRLRRkWE X +LYN LYN P07948 human Lasp-1 3927 Q14847 LASP1 human Y171 451675 IPtsAPVyQQPQQQP X +LYN LYN P07948 human YY1 7528 P25490 YY1 human Y254 464367 sPPDySEyMTGkKLP X +LYN LYN P07948 human WASP 7454 P42768 WAS human Y291 447985 AEtsKLIyDFIEDQG PBD X +LYN LYN P07948 human Syk 20963 P48025 Syk mouse Y346 447660 TEVyESPyADPEEIR X 2701; 2717; 14791; 73382; 82975; 31754 +LYN LYN P07948 human SLCO1B1 10599 Q9Y6L6 SLCO1B1 human Y645 13831749 VLyIILIyAMKKKYQ TM X +LYN LYN P07948 human MCM7 4176 P33993 MCM7 human Y600 463418 WASkDAtyTSARtLL MCM_lid X X +LYN LYN P07948 human DAPP1 27071 Q9UN19 DAPP1 human Y139 448325 kVEEPsIyEsVRVHT X 13703 +LYN LYN P07948 human AFAP1L1 106877 Q8BZI0 Afap1l1 mouse Y557 462143 QWPEPRIyDEVPYEK X +LYN LYN P07948 human TIF1B 10155 Q13263 TRIM28 human Y458 454817 FGsGDDPyssAEPHV X +LYN LYN P07948 human AKAP8 10270 O43823 AKAP8 human Y311 3582467 KRkQFQLyEEPDTkL X +LYN LYN P07948 human AKAP8 10270 O43823 AKAP8 human Y436 40420003 TVEFLQEyIVNRNKK AKAP95 X +LYN LYN P07948 human NIPP-1 5511 Q12972 PPP1R8 human Y335 3101800 NEPKKKKyAKEAWPG X +LYN LYN P07948 human IKKG 8517 Q9Y6K9 IKBKG human Y374 473650 PLPPAPAyLssPLAL X +RPS6KA3 RSK2 P51812 human NFAT3 4776 Q14934 NFATC4 human S289 4777119 PALsRRGsLGEEGsE X X +RPS6KA3 RSK2 P51812 human KIBRA 23286 Q8IX03 WWC1 human S947 453630 CRLNRsDsDSSTLSK X X +RPS6KA3 RSK2 P51812 human NFAT3 4776 Q14934 NFATC4 human S281 13419502 SGTPSSAsPALsRRG X X +RPS6KA3 RSK2 P51812 human TH iso4 7054 P07101-4 TH human S44 448545 RFIGRRQsLIEDARK TOH_N X 2791 +RPS6KA3 RSK2 P51812 human RIOK2 55781 Q9BVS4 RIOK2 human S483 7446950 QYRTRtLsItssGsA X +RPS6KA3 RSK2 P51812 human Nur77 15370 P12813 Nr4a1 mouse S354 447942 GRRGRLPsKPKQPPD X 5095 +RPS6KA3 RSK2 P51812 human PKR 5610 P19525 EIF2AK2 human T451 448089 kRtRSKGtLRyMsPE Pkinase X +RPS6KA3 RSK2 P51812 human MASTL 67121 Q8C0P0 Mastl mouse T297 1269647500 QCRKRLGtSSTSSQS X +RPS6KA3 RSK2 P51812 human YB-1 4904 P67809 YBX1 human S102 455636 NPRKyLrsVGDGEtV CSD X X 2900 +RPS6KA3 RSK2 P51812 human TINF2 26277 Q9BSI4 TINF2 human S295 3245684 FPFRNLGsPtQVISk X X +RPS6KA3 RSK2 P51812 human H3 8350 P68431 H3C1 human S10 455676 tkQtArkstGGkAPr Histone X 9701; 9711; 9606; 3465; 3642; 3377; 3475; 3458; 5764; 47398; 8481; 8552; 53348; 29237; 66065; 43185; 64522; 52725 +RPS6KA3 RSK2 P51812 human TIF1A 54700 Q9NYV6 RRN3 human S649 448839 PVLYMQPsPL_____ X +RPS6KA3 RSK2 P51812 human S6 20104 P62754 Rps6 mouse S235 448092 IAKRRRLssLRAsts X 5006; 4856; 4857; 4858; 4851; 4803; 2211; 3945; 3985; 5316; 4854; 8520; 48319; 40643; 9865; 38573; 14733; 27036; 34411; 62016; 62788; 81736; 97935; 99457; 15448 +RPS6KA3 RSK2 P51812 human L-plastin 3936 P13796 LCP1 human S5 450852 ___MARGsVsDEEMM X +RPS6KA3 RSK2 P51812 human MRLC3 10627 P19105 MYL12A human S19 7382102 KRPQRAtsNVFAMFD X X +RPS6KA3 RSK2 P51812 human TBX21 30009 Q9UL17 TBX21 human S503 56676120 DSKRRRVsPYPsSGD X X +RPS6KA3 RSK2 P51812 human TBX21 30009 Q9UL17 TBX21 human S507 322212300 RRVsPYPsSGDSsSP X X +RPS6KA3 RSK2 P51812 human ASK1 4217 Q99683 MAP3K5 human T1109 27928508 DRKIIATtLSKLkLE HisK-N-like X X +RPS6KA3 RSK2 P51812 human DAPK1 1612 P53355 DAPK1 human S289 457379 QALSRKAsAVNMEkF X +RPS6KA3 RSK2 P51812 human CREB iso1 81646 P15337-1 Creb1 rat S133 448228 EILsRRPsYRkILND pKID X 9187; 9196; 9198; 4095; 14228; 14001; 39561; 80120; 44864; 54960; 95995 +RPS6KA3 RSK2 P51812 human STAT3 6774 P40763 STAT3 human S727 448191 NtIDLPMsPrTLDSL X 9134; 9136; 34911; 94994; 49081; 58978; 87544; 71958; 50804 +RPS6KA3 RSK2 P51812 human STMN1 3925 P16949 STMN1 human S16 448554 kELEKrAsGQAFELI Stathmin X X 3353 +RPS6KA3 RSK2 P51812 human EphA2 1969 P29317 EPHA2 human S897 1244153 RVsIRLPstsGsEGV X X 16662; 6347 +RPS6KA3 RSK2 P51812 human BAD 572 Q92934 BAD human S99 447862 PFrGrsRsAPPNLWA Bcl-2_BAD X 9295; 5286; 4366 +RPS6KA3 RSK2 P51812 human NFAT3 4776 Q14934 NFATC4 human S344 11163859 QAVALPRsEEPASCN X X +RPS6KA3 RSK2 P51812 human KIBRA 23286 Q8IX03 WWC1 human T929 3205626 stIIRsKtFsPGPQS X X +RPS6KA3 RSK2 P51812 human IkB-alpha 4792 P25963 NFKBIA human S32 448203 LLDDRHDsGLDsMkD X X 5210; 2859; 9246; 5209 +RPS6KA3 RSK2 P51812 human GSK3A 2931 P49840 GSK3A human S21 448584 sGrARtssFAEPGGG X 9337; 9316; 9331; 5090; 9327; 8452; 8566 +RPS6KA3 RSK2 P51812 human PPP1R3A 5506 Q16821 PPP1R3A human S65 449321 SSGTRRVsFADSFGF X +RPS6KA3 RSK2 P51812 human NFAT3 4776 Q14934 NFATC4 human S676 455348 SNGRRKRsPTQSFRF RHD_dimer X X +RPS6KA3 RSK2 P51812 human 5-HT(2A) 29595 P14842 Htr2a rat S314 6057801 AGRRTMQsISNEQKA 7tm_1 X X +RPS6KA3 RSK2 P51812 human NFAT3 4776 Q14934 NFATC4 human S285 13419501 SSAsPALsRRGsLGE X X +RPS6KA3 RSK2 P51812 human SPRED2 200734 Q7Z698 SPRED2 human S168 12738131 QPTRTIssPTSCEHR X X +RPS6KA3 RSK2 P51812 human ASK1 4217 Q99683 MAP3K5 human S83 447735 ATRGRGssVGGGSrR X X 3761 +RPS6KA3 RSK2 P51812 human BAD 572 Q92934 BAD human S75 447860 EIRsRHssyPAGtED Bcl-2_BAD X X 9291; 5284; 9296; 5193; 11865; 94223 +RPS6KA3 RSK2 P51812 human CASP8 841 Q14790 CASP8 human T263 21258500 SIRDRNGtHLDAGAL Peptidase_C14 X X +RPS6KA3 RSK2 P51812 human PFKFB2 287019 P26285 PFKFB2 cow S484 452046 IRRPRNYsVGSRPLQ X +RPS6KA3 RSK2 P51812 human CREB 1385 P16220 CREB1 human S119 448228 EILsRRPsyRkILND pKID X 9187; 9196; 9198; 4095; 14228; 14001; 39561; 80120; 44864; 54960; 95995 +RPS6KA3 RSK2 P51812 human GSK3B 2932 P49841 GSK3B human S9 449111 SGRPRttsFAEsCkP X X 9336; 9331; 9327; 9323; 9322; 9325; 5558; 8566; 79774; 8466; 25462; 14026; 14332; 14310; 14630 +RPS6KA3 RSK2 P51812 human RANBP3 8498 Q9H6Z4 RANBP3 human S126 460735 VKRERtssLtQFPPs X 9380 +RPS6KA3 RSK2 P51812 human GATA4 54254 P46152 Gata4 rat S261 450013 IKPQRRLsASRRVGL X +RPS6KA3 RSK2 P51812 human ER-alpha 2099 P03372 ESR1 human S167 448102 GGRERLAsTNDkGSM Oest_recep X 64508; 42101 +RPS6KA3 RSK2 P51812 human H2AX 3014 P16104 H2AX human S16 33703202 kARAkAksRSsrAGL Histone X X +RPS6KA3 RSK2 P51812 human S6 6194 P62753 RPS6 human S236 448093 AKRRRLssLRAstsK X 5006; 4856; 4857; 4858; 4851; 4803; 2211; 3945; 3985; 5316; 4854; 8520; 48319; 40643; 9865; 38573; 14733; 27036; 34411; 62016; 62788; 81736; 97935; 99457; 15448 +RPS6KA3 RSK2 P51812 human RSK2 6197 P51812 RPS6KA3 human S386 448065 HQLFRGFsFVAItsD Pkinase_C X 9341; 9335; 13575; 11989; 12032; 75266; 93317; 13397; 13588 +RPS6KA3 RSK2 P51812 human VGLL1 51442 Q99990 VGLL1 human S84 1870773106 PNQWRYSsPWTKPQP X +RPS6KA3 RSK2 P51812 human NFkB-p65 5970 Q04206 RELA human S276 447798 sMQLRRPsDRELsEP RHD_dimer X +RPS6KA3 RSK2 P51812 human TINF2 26277 Q9BSI4 TINF2 human S330 7322600 ASTGKSKsPCQTLGG X X +RPS6KA3 RSK2 P51812 human TH iso2 7054 P07101-2 TH human S67 448545 RFIGRRQsLIEDARK TOH_N X 2791 +RPS6KA3 RSK2 P51812 human ASK1 4217 Q99683 MAP3K5 human T1326 27928509 VNGADEDtISRFLAE X X +RPS6KA3 RSK2 P51812 human S6 29304 P62755 Rps6 rat S236 448093 AKRRRLssLRAstsK X 5006; 4856; 4857; 4858; 4851; 4803; 2211; 3945; 3985; 5316; 4854; 8520; 48319; 40643; 9865; 38573; 14733; 27036; 34411; 62016; 62788; 81736; 97935; 99457; 15448 +RPS6KA3 RSK2 P51812 human TH 7054 P07101 TH human S71 448545 RFIGRRQsLIEDARK TOH_N X 2791 +RPS6KA3 RSK2 P51812 human PPP1R3A 5506 Q16821 PPP1R3A human S46 449320 PQPSRRGsDssEDIY X +RPS6KA3 RSK2 P51812 human ATF-4 468 P18848 ATF4 human S245 451446 TrGSPNRsLPsPGVL X X +RPS6KA3 RSK2 P51812 human FOXN2 3344 P32314 FOXN2 human S369 799824600 LGDsGYAsQPCAKIS X +RPS6KA3 RSK2 P51812 human FOXN2 3344 P32314 FOXN2 human S365 799824601 EDDPLGDsGYAsQPC X +RPS6KA3 RSK2 P51812 human MYBPC3 295929 P56741 Mybpc3 rat S288 471080 AGTGRRtsDSHEDAG X +RPS6KA3 RSK2 P51812 human SPRED2 200734 Q7Z698 SPRED2 human S167 23147996 EQPTRTIssPTSCEH X X +RPS6KA3 RSK2 P51812 human H2B 3018 P33778 H2BC3 human S32 447801 DGKkRKRsRkEsysI Histone X X +RPS6KA3 RSK2 P51812 human PFKFB2 287019 P26285 PFKFB2 cow S467 448460 PVRMRRNsFTPLSSS X +RPS6KA3 RSK2 P51812 human FGFR1 2260 P11362 FGFR1 human S789 4703530 DTRSSTCsSGEDSVF X X +RPS6KA3 RSK2 P51812 human S6 6194 P62753 RPS6 human S235 448092 IAKRRRLssLRAsts X 5006; 4856; 4857; 4858; 4851; 4803; 2211; 3945; 3985; 5316; 4854; 8520; 48319; 40643; 9865; 38573; 14733; 27036; 34411; 62016; 62788; 81736; 97935; 99457; 15448 +RPS6KA3 RSK2 P51812 human NHE3 6550 P48764 SLC9A3 human S663 457469 TMRKRLEsFKSTKLG X +RPS6KA3 RSK2 P51812 human TH iso3 7054 P07101-3 TH human S40 448545 RFIGRRQsLIEDARK TOH_N X 2791 +RPS6KA3 RSK2 P51812 human capicua 23152 Q96RK0 CIC human S173 3209781 PGKRRtQsLsALPKE X +RPS6KA3 RSK2 P51812 human C/EBP-beta 24253 P21272 Cebpb rat S273 13373502 QKKVEQLsRELSTLR bZIP_2 X +RPS6KA3 RSK2 P51812 human eIF2-alpha 1965 P05198 EIF2S1 human S52 447635 MILLsELsRRRIRsI S1 X 3597; 9721; 3398; 5199; 53085; 95797 +RPS6KA3 RSK2 P51812 human S6 20104 P62754 Rps6 mouse S236 448093 AKRRRLssLRAstsK X 5006; 4856; 4857; 4858; 4851; 4803; 2211; 3945; 3985; 5316; 4854; 8520; 48319; 40643; 9865; 38573; 14733; 27036; 34411; 62016; 62788; 81736; 97935; 99457; 15448 +RPS6KA3 RSK2 P51812 human KCNK3 3777 O14649 KCNK3 human S393 2840504 GLMKRRssV______ X +TTBK2 TTBK2 Q6IQ55 human SV2A 9900 Q7L0J3 SV2A human S47 4779746 EysRRsYsRFEEEDD X +TTBK2 TTBK2 Q6IQ55 human SV2A 9900 Q7L0J3 SV2A human T84 4779764 GGAssDAtEGHDEDD X +TTBK2 TTBK2 Q6IQ55 human SV2A 9900 Q7L0J3 SV2A human S45 40245506 QDEysRRsYsRFEEE X +TTBK2 TTBK2 Q6IQ55 human CCDC41 51134 Q9Y592 CEP83 human S698 14571164 KQLEELGsSGE____ X X +TTBK2 TTBK2 Q6IQ55 human SV2A 9900 Q7L0J3 SV2A human S80 4779752 DEEEGGAssDAtEGH X +TTBK2 TTBK2 Q6IQ55 human SV2A 9900 Q7L0J3 SV2A human S81 4779758 EEEGGAssDAtEGHD X +TTBK2 TTBK2 Q6IQ55 human SV2A 9900 Q7L0J3 SV2A human S42 15415491 DRVQDEysRRsYsRF X +TTBK2 TTBK2 Q6IQ55 human KIF2A 3796 O00139 KIF2A human S135 4705535 SSAQQNGsVsDIsPV X X +Csnk1g2 CK1G2 Q8BVP5 mouse CK1G2 103236 Q8BVP5 Csnk1g2 mouse T215 1871246001 EHKsLTGtARYMSIN Pkinase X +Csnk1g2 CK1G2 Q8BVP5 mouse CK1G2 103236 Q8BVP5 Csnk1g2 mouse S211 1871246000 IPYREHKsLTGtARY Pkinase X +BTK Btk Q06187 human GTF2I iso2 2969 P78347-2 GTF2I human Y248 448250 EESEDPDyyQyNIQG X X +BTK Btk Q06187 human PLCG2 5336 P16885 PLCG2 human Y753 447940 ERDINSLyDVsRMyV X X +BTK Btk Q06187 human TIRAP 114609 P58753 TIRAP human Y106 463809 AAQDLVSyLEGSTAS TIR_2 X +BTK Btk Q06187 human Btk 12229 P35991 Btk mouse Y223 447485 LKKVVALyDyMPMNA SH3_1 X 5082; 87141; 87457 +BTK Btk Q06187 human Etk 660 P51813 BMX human Y216 449835 SSTSLAQyDSNSKKI X +BTK Btk Q06187 human Ikaros 10320 Q13422 IKZF1 human S214 28735108 GRSYKQRssLEEHkE zf-C2H2 X +BTK Btk Q06187 human CREB iso1 81646 P15337-1 Creb1 rat S133 448228 EILsRRPsYRkILND pKID X 9187; 9196; 9198; 4095; 14228; 14001; 39561; 80120; 44864; 54960; 95995 +BTK Btk Q06187 human PLCG2 29337 P24135 Plcg2 rat Y753 447940 ERDINSLyDVSRMyV X X +BTK Btk Q06187 human Ikaros 10320 Q13422 IKZF1 human S215 28735107 RSYKQRssLEEHkER zf-C2H2 X +BTK Btk Q06187 human TIRAP 114609 P58753 TIRAP human Y86 463808 SSRWSKDyDVCVCHS X +BTK Btk Q06187 human TEC 7006 P42680 TEC human Y206 449836 RLERGQEyLILEKND SH3_1 X +BTK Btk Q06187 human GTF2I iso2 2969 P78347-2 GTF2I human Y357 448251 QSHVEDLyVEGLPEG GTF2I X X +BTK Btk Q06187 human PLCG2 29337 P24135 Plcg2 rat Y1197 447938 LESEEELySSCRQLR X X +BTK Btk Q06187 human IkB-alpha 4792 P25963 NFKBIA human Y305 448799 FtEDELPyDDCVFGG X X +BTK Btk Q06187 human PLCG2 29337 P24135 Plcg2 rat Y1217 447939 LNNQLFLyDTHQNLR X X 3871 +BTK Btk Q06187 human Btk 695 Q06187 BTK human Y223 447485 LKKVVALyDyMPMNA SH3_1 X X 5082; 87141; 87457 +BTK Btk Q06187 human ITK 3702 Q08881 ITK human Y180 449834 ETVVIALyDyQtNDP SH3_1 X +BTK Btk Q06187 human TIRAP 114609 P58753 TIRAP human Y187 463810 SGLSRAAyPPELRFM TIR_2 X +BTK Btk Q06187 human PLCG2 5336 P16885 PLCG2 human Y759 447941 LyDVsRMyVDPsEIN X X 3874; 50535 +BTK Btk Q06187 human G3BP-1 10146 Q13283 G3BP1 human Y40 1877717200 FYGkNSSyVHGGLDs NTF2 X +BTK Btk Q06187 human STAT5A 20850 P42230 Stat5a mouse Y694 447767 LAKAVDGyVkPQIKQ X 9365; 9356; 9359; 9351; 4322; 9314; 3939; 40284; 5387; 14603; 66740; 51879; 72712 +BTK Btk Q06187 human IkB-alpha 4792 P25963 NFKBIA human Y289 1867984206 EsEDEEsyDtEsEFT X +BTK Btk Q06187 human DDX41 51428 Q9UJV9 DDX41 human Y414 40253300 DVIQEVEyVkEEAKM X X +BTK Btk Q06187 human GTF2I iso2 2969 P78347-2 GTF2I human Y462 448252 EAHPNDLyVEGLPEN GTF2I X X +BTK Btk Q06187 human Btk 695 Q06187 BTK human Y551 447486 RYVLDDEytsSVGSk PK_Tyr_Ser-Thr X X 69360; 18805; 64137; 16803 +BTK Btk Q06187 human p53 7157 P04637 TP53 human S15 447490 PsVEPPLsQEtFsDL P53_TAD X X 4030; 9235; 9284; 9286; 8695; 8514; 82530; 56979 +BTK Btk Q06187 human PLCG2 29337 P24135 Plcg2 rat Y759 447941 LyDVSRMyVDPSEIN X X 3874; 50535 +BTK Btk Q06187 human PLCG2 5336 P16885 PLCG2 human Y1217 447939 LNNQLFLyDtHQNLR X 3871 +Camk2g CAMK2G Q923T9 mouse STAT1 6772 P42224 STAT1 human S727 447753 TDNLLPMsPEEFDEV STAT1_TAZ2bind X 9177; 8826; 62390 +Camk2g CAMK2G Q923T9 mouse ANO1 101772 Q8BHY3 Ano1 mouse S673 288031701 YLKLRRQsPSDREEY Anoctamin X +IRAK4 IRAK4 Q9NWZ3 human PELI1 57162 Q96FA3 PELI1 human T80 7388010 DQHsIsYtLsRAQtV Pellino X +IRAK4 IRAK4 Q9NWZ3 human p47phox 653361 P14598 NCF1 human S348 451728 PGPQsPGsPLEEERQ X +IRAK4 IRAK4 Q9NWZ3 human IRAK4 51135 Q9NWZ3 IRAK4 human T345 2045325 kFAQtVMtsRIVGTt PK_Tyr_Ser-Thr X X 12914; 11927; 80738; 87995 +IRAK4 IRAK4 Q9NWZ3 human PELI1 57162 Q96FA3 PELI1 human T288 7388016 QCPVGFNtLAFPsMk Pellino X +IRAK4 IRAK4 Q9NWZ3 human PELI1 57162 Q96FA3 PELI1 human T127 7452903 GSQSNsDtQSVQSTI Pellino X +IRAK4 IRAK4 Q9NWZ3 human p47phox 653361 P14598 NCF1 human T356 474563 PLEEERQtQRsKPQP X X +IRAK4 IRAK4 Q9NWZ3 human p47phox 653361 P14598 NCF1 human S320 451726 QRsRKRLsQDAYRRN NECFESHC X X +IRAK4 IRAK4 Q9NWZ3 human IRAK1 3654 P51617 IRAK1 human S376 449756 GSsPsQssMVARtQT Pkinase X +IRAK4 IRAK4 Q9NWZ3 human IRAK4 51135 Q9NWZ3 IRAK4 human T209 2859006 KGYVNNttVAVKKLA PK_Tyr_Ser-Thr X +IRAK4 IRAK4 Q9NWZ3 human IRAK4 51135 Q9NWZ3 IRAK4 human S8 2859004 MNkPItPsTYVRCLN X +IRAK4 IRAK4 Q9NWZ3 human IRAK4 51135 Q9NWZ3 IRAK4 human S346 2045338 FAQtVMtsRIVGTtA PK_Tyr_Ser-Thr X X 12914; 11927; 80738; 87995 +IRAK4 IRAK4 Q9NWZ3 human p47phox 653361 P14598 NCF1 human S370 451730 PAVPPRPsADLILNR p47_phox_C X +IRAK4 IRAK4 Q9NWZ3 human PELI1 57162 Q96FA3 PELI1 human S82 7388012 HsIsYtLsRAQtVVV Pellino X +IRAK4 IRAK4 Q9NWZ3 human IRAK4 51135 Q9NWZ3 IRAK4 human T342 2045344 AsEkFAQtVMtsRIV PK_Tyr_Ser-Thr X X +IRAK4 IRAK4 Q9NWZ3 human IRAK4 51135 Q9NWZ3 IRAK4 human T352 31823504 tsRIVGTtAYMAPEA PK_Tyr_Ser-Thr X +IRAK4 IRAK4 Q9NWZ3 human PELI1 57162 Q96FA3 PELI1 human S70 7452902 PQAAKAIsNKDQHsI Pellino X +IRAK4 IRAK4 Q9NWZ3 human p47phox 653361 P14598 NCF1 human S288 474561 QKsGQDVsQAQRQIK NECFESHC X X +IRAK4 IRAK4 Q9NWZ3 human p47phox 653361 P14598 NCF1 human T153 474560 KSTATDItGPIILQT X +IRAK4 IRAK4 Q9NWZ3 human IRAK1 3654 P51617 IRAK1 human T387 447721 RtQTVRGtLAYLPEE Pkinase X +IRAK4 IRAK4 Q9NWZ3 human IRAK4 51135 Q9NWZ3 IRAK4 human T208 2859008 YKGYVNNttVAVKKL PK_Tyr_Ser-Thr X +IRAK4 IRAK4 Q9NWZ3 human PELI1 57162 Q96FA3 PELI1 human S78 7388013 NKDQHsIsYtLsRAQ Pellino X +IRAK4 IRAK4 Q9NWZ3 human PELI1 57162 Q96FA3 PELI1 human T86 7388011 YtLsRAQtVVVEYTH Pellino X +IRAK4 IRAK4 Q9NWZ3 human p47phox 653361 P14598 NCF1 human S345 451727 QARPGPQsPGsPLEE X X +IRAK4 IRAK4 Q9NWZ3 human p47phox 653361 P14598 NCF1 human T133 474558 KLPTDNQtKKPEtyL X X +IRAK4 IRAK4 Q9NWZ3 human p47phox 653361 P14598 NCF1 human T138 474559 NQtKKPEtyLMPKDG X +IRAK4 IRAK4 Q9NWZ3 human IRAK4 51135 Q9NWZ3 IRAK4 human T6 2859005 __MNkPItPsTYVRC X +IRAK4 IRAK4 Q9NWZ3 human IRAK4 51135 Q9NWZ3 IRAK4 human S151 2859001 SYMPPDsssPENKsL X +IRAK4 IRAK4 Q9NWZ3 human PELI1 57162 Q96FA3 PELI1 human S293 7388014 FNtLAFPsMkRkDVV Pellino X +IRAK4 IRAK4 Q9NWZ3 human IRAK4 51135 Q9NWZ3 IRAK4 human S152 2859003 YMPPDsssPENKsLE X +IRAK4 IRAK4 Q9NWZ3 human IRAK4 51135 Q9NWZ3 IRAK4 human S114 2859007 KTANTLPskEAITVQ X +IRAK4 IRAK4 Q9NWZ3 human PELI1 57162 Q96FA3 PELI1 human S76 7388015 IsNKDQHsIsYtLsR Pellino X +IRAK4 IRAK4 Q9NWZ3 human IRAK4 51135 Q9NWZ3 IRAK4 human S150 2859002 QSYMPPDsssPENKs X +IRAK4 IRAK4 Q9NWZ3 human p47phox 653361 P14598 NCF1 human S359 451729 EERQtQRsKPQPAVP p47_phox_C X +Mapk8 JNK1 Q91Y86 mouse JunB 3726 P17275 JUNB human T102 1814001 SNGVITTtPtPPGQy Jun X 8053 +Mapk8 JNK1 Q91Y86 mouse Jun 16476 P05627 Jun mouse S73 447943 VGLLKLAsPELERLI Jun X X 9164; 3270; 8752; 12714; 77955 +Mapk8 JNK1 Q91Y86 mouse EEF1A2 1917 Q05639 EEF1A2 human S358 27930803 GQISAGYsPVIDCHT GTP_EFTU_D3 X +Mapk8 JNK1 Q91Y86 mouse NET1 307098 A0A8I6AVA8 Net1 rat S106 3204291 TSLANLIsPVRNGAV X +Mapk8 JNK1 Q91Y86 mouse ATF-2 1386 P15336 ATF2 human T71 448225 IVADQtPtPtRFLkN X 9225; 9221; 5112; 94125; 13850; 40749; 15411; 24329; 61584; 27934; 92109; 20534; 35858 +Mapk8 JNK1 Q91Y86 mouse SIRT1 93759 Q923E4 Sirt1 mouse S46 452899 DGPGLGRsPGEPsAA X +Mapk8 JNK1 Q91Y86 mouse NRL 18185 P54846 Nrl mouse S50 478419 PYSSVPPsPTFSEPG X +Mapk8 JNK1 Q91Y86 mouse NFAT3 4776 Q14934 NFATC4 human S217 953803 GLGsPLPsPRAsPRP X +Mapk8 JNK1 Q91Y86 mouse SARM1 287545 D3ZUM2 Sarm1 rat S548 4739912 AAREMLHsPLPCTGG X +Mapk8 JNK1 Q91Y86 mouse DICER1 192119 Q8R418 Dicer1 mouse S1456 31084113 IDSMLMGsGAFVRkI Ribonuclease_3 X +Mapk8 JNK1 Q91Y86 mouse MLP 17357 P28667 Marcksl1 mouse T183 454301 PQAAEPstPsGPEsG MARCKS X +Mapk8 JNK1 Q91Y86 mouse BMAL1 406 O00327 BMAL1 human S592 25352000 DNDQGSSsPSNDEAA X +Mapk8 JNK1 Q91Y86 mouse RXRA 20181 P28700 Rxra mouse S265 450891 NMGLNPSsPNDPVTN Hormone_recep X +Mapk8 JNK1 Q91Y86 mouse BMAL1 406 O00327 BMAL1 human S520 25352001 SPSSCGSsPLNITSt X +Mapk8 JNK1 Q91Y86 mouse LISCH iso2 54135 Q99KG5-2 Lsr mouse S288 4771509 PGDFDRTsSVGGHSS X X +Mapk8 JNK1 Q91Y86 mouse STMN2 20257 P55821 Stmn2 mouse S62 450174 ELILKPPsPIsEAPR Stathmin X +Mapk8 JNK1 Q91Y86 mouse BAD 12015 Q61337 Bad mouse S112 447860 ETRsRHssyPAGtEE Bcl-2_BAD X X 9291; 5284; 9296; 5193; 11865; 94223 +Mapk8 JNK1 Q91Y86 mouse PPAR-gamma 19016 P37238 Pparg mouse S112 448062 AIkVEPAsPPYYSEK X +Mapk8 JNK1 Q91Y86 mouse Jun 16476 P05627 Jun mouse T93 450449 GHITTtPtPtQFLCP Jun X X 2993 +Mapk8 JNK1 Q91Y86 mouse RXRA 20181 P28700 Rxra mouse S61 453094 SPISTLSsPINGMGP Nuc_recep-AF1 X +Mapk8 JNK1 Q91Y86 mouse IRX3 16373 P81067 Irx3 mouse S389 1874748506 APPTLQLsPAAAAAA X +Mapk8 JNK1 Q91Y86 mouse STAT3 20848 P42227 Stat3 mouse S727 448191 NtIDLPMsPRTLDSL X 9134; 9136; 34911; 94994; 49081; 58978; 87544; 71958; 50804 +Mapk8 JNK1 Q91Y86 mouse ATF-2 11909 P16951 Atf2 mouse T51 448224 sVIVADQtPtPtRFL X X 9225; 94125; 40749; 61584; 44167 +Mapk8 JNK1 Q91Y86 mouse BAD 12015 Q61337 Bad mouse S128 447861 EGMEEELsPFRGRsR Bcl-2_BAD X +Mapk8 JNK1 Q91Y86 mouse BIM 12125 O54918 Bcl2l11 mouse S65 449330 GPLAPPAsPGPFATR X 4581; 4585 +Mapk8 JNK1 Q91Y86 mouse Jun 16476 P05627 Jun mouse T91 450448 sNGHITTtPtPtQFL Jun X X 2303 +Mapk8 JNK1 Q91Y86 mouse MLP 17357 P28667 Marcksl1 mouse S120 454291 GGDssAssPtEEEQE MARCKS X +Mapk8 JNK1 Q91Y86 mouse RXRA 20181 P28700 Rxra mouse S75 453095 PPFSVISsPMGPHSM Nuc_recep-AF1 X +Mapk8 JNK1 Q91Y86 mouse ELK3 13713 P41971 Elk3 mouse S359 450031 IHFWSSLsPVAPLsP X X +Mapk8 JNK1 Q91Y86 mouse JDP2 81703 P97875 Jdp2 mouse T148 448312 VRTDsVRtPEsEGNP X +Mapk8 JNK1 Q91Y86 mouse Doublecortin 13193 O88809 Dcx mouse S332 451363 StPKsKQsPIStPts X +Mapk8 JNK1 Q91Y86 mouse EEF1A2 1917 Q05639 EEF1A2 human S205 27930804 GDNMLEPsPNMPWFK GTP_EFTU X +Mapk8 JNK1 Q91Y86 mouse RXRA 20181 P28700 Rxra mouse T87 453096 HSMSVPTtPTLGFGT Nuc_recep-AF1 X +Mapk8 JNK1 Q91Y86 mouse BAD 12015 Q61337 Bad mouse T201 450485 NLGKGGStPSQ____ Bcl-2_BAD X X +Mapk8 JNK1 Q91Y86 mouse IRX3 16373 P81067 Irx3 mouse S361 1874748504 SLAETATsPDNPRRS X +Mapk8 JNK1 Q91Y86 mouse IRS1 16367 P35569 Irs1 mouse S307 447558 tEsITAtsPAsMVGG X 2381 +Mapk8 JNK1 Q91Y86 mouse NFAT3 4776 Q14934 NFATC4 human S213 953804 ASRFGLGsPLPsPRA X +Mapk8 JNK1 Q91Y86 mouse H3 iso3 15081 P84244 H3f3b mouse S28 455677 ATkAArksAPSTGGV Histone X 9713 +Mapk8 JNK1 Q91Y86 mouse STMN2 20257 P55821 Stmn2 mouse S73 450173 EAPRTLAsPKKKDLs Stathmin X +Mapk8 JNK1 Q91Y86 mouse Jun 16476 P05627 Jun mouse S63 447686 kNsDLLtsPDVGLLK Jun X X 5464; 9261; 2361; 97721; 91952 +Mapk8 JNK1 Q91Y86 mouse ATF-2 11909 P16951 Atf2 mouse T53 448225 IVADQtPtPtRFLKN X 9225; 9221; 5112; 94125; 13850; 40749; 15411; 24329; 61584; 27934; 92109; 20534; 35858 +Mapk8 JNK1 Q91Y86 mouse p70S6K 6198 P23443 RPS6KB1 human S434 448356 sFEPKIRsPRRFIGs X +Mapk8 JNK1 Q91Y86 mouse JunB 3726 P17275 JUNB human T104 1814000 GVITTtPtPPGQyFy Jun X 8053 +Mapk8 JNK1 Q91Y86 mouse PYCARD 66824 Q9EPB4 Pycard mouse Y144 465096 SVLTEGQyQAVRAET CARD X +Mapk8 JNK1 Q91Y86 mouse MLP 17357 P28667 Marcksl1 mouse T148 454299 QEGKAAAtPEsQEPQ MARCKS X +Mapk8 JNK1 Q91Y86 mouse H2AX 15270 P27661 H2ax mouse S139 448841 GkKAsQAsQEy____ X X 2577; 9719; 9720; 9718; 4309; 5763; 5438; 93629; 80312; 20304; 85410; 97148; 60566; 59141 +Mapk8 JNK1 Q91Y86 mouse BIM 12125 O54918 Bcl2l11 mouse T112 449071 sCDKStQtPsPPCQA X +Mapk8 JNK1 Q91Y86 mouse BMAL1 406 O00327 BMAL1 human T527 448633 sPLNITStPPPDASS X +Mapk8 JNK1 Q91Y86 mouse ELK3 13713 P41971 Elk3 mouse S365 450032 LsPVAPLsPARLQGP X X +Mapk8 JNK1 Q91Y86 mouse STAT1 20846 P42225 Stat1 mouse S727 447753 tDNLLPMsPEEFDEM STAT1_TAZ2bind X 9177; 8826; 62390 +RIOK1 RIOK1 Q9BRS2 human G3BP-2 9908 Q9UN86 G3BP2 human T226 3072179 EELEEKsttPPPAEP X +TNIK TNIK Q9UKE5 human SMAD1 4086 Q15797 SMAD1 human T322 25802105 sNVNRNStIENTRRH MH2 X X +TNIK TNIK Q9UKE5 human TCF7L2 6934 Q9NQB0 TCF7L2 human S177 14918200 QALkDARsPsPAHIV CTNNB1_binding X X +TNIK TNIK Q9UKE5 human Huntingtin 3064 P42858 HTT human S13 10206805 kLMkAFEsLksFQQQ X X +TNIK TNIK Q9UKE5 human Huntingtin 3064 P42858 HTT human T3 10206804 _____MAtLEkLMkA X X +GRK2 GRK2 P21146 cow PDGFRB 5159 P09619 PDGFRB human S1104 454229 PRAEAEDsFL_____ X +GRK2 GRK2 P21146 cow DOR-1 18386 P32300 Oprd1 mouse S363 448550 RVtACtPsDGPGGGA X +GRK2 GRK2 P21146 cow ADRA1B 101843941 P18841 ADRA1B hamster S404 451004 RSQsRKDsLDDsGsC X +GRK2 GRK2 P21146 cow NEDD4 17999 P46935 Nedd4 mouse T470 482846 PPGWEERtHTDGRVF WW X +GRK2 GRK2 P21146 cow ADRB2 154 P07550 ADRB2 human S355 458916 KAyGNGyssNGNtGE X X +GRK2 GRK2 P21146 cow ADRA1B 101843941 P18841 ADRA1B hamster S408 451005 RKDsLDDsGsCMSGS X +GRK2 GRK2 P21146 cow MC4R 4160 P32245 MC4R human S329 449102 LGGLCDLssRY____ X +GRK2 GRK2 P21146 cow MC4R 4160 P32245 MC4R human S330 449103 GGLCDLssRY_____ X +GRK2 GRK2 P21146 cow DOR-1 18386 P32300 Oprd1 mouse T358 449761 AttRERVtACtPsDG X +GRK2 GRK2 P21146 cow ADRB2 154 P07550 ADRB2 human S356 458917 AyGNGyssNGNtGEQ X X +GRK2 GRK2 P21146 cow ADRA1B 101843941 P18841 ADRA1B hamster S410 451006 DsLDDsGsCMSGSQR X +TTBK1 TTBK1 Q5TCY1 human Tau iso8 4137 P10636-8 MAPT human S199 447927 GDRsGyssPGsPGtP X X 29957 +TTBK1 TTBK1 Q5TCY1 human Tau 281296 P29172 MAPT cow S242 449080 VVRTPPKsPSAAKSR X 20473 +TTBK1 TTBK1 Q5TCY1 human Tau 281296 P29172 MAPT cow S403 449081 GAEIVYKsPVVSGDT X +TTBK1 TTBK1 Q5TCY1 human Tau iso8 4137 P10636-8 MAPT human S202 447928 sGyssPGsPGtPGsR X X 39357; 30505 +TTBK1 TTBK1 Q5TCY1 human Tau iso8 4137 P10636-8 MAPT human S198 449551 sGDRsGyssPGsPGt X X +TTBK1 TTBK1 Q5TCY1 human Tau 281296 P29172 MAPT cow S209 447928 sGYSSPGsPGtPGSR X 39357; 30505 +TTBK1 TTBK1 Q5TCY1 human Tau 281296 P29172 MAPT cow S202 450221 SGKSGDRsGYSSPGs X +TTBK1 TTBK1 Q5TCY1 human Tau iso8 4137 P10636-8 MAPT human T427 474503 VDsPQLAtLADEVsA X +TTBK1 TTBK1 Q5TCY1 human Tau iso8 4137 P10636-8 MAPT human Y197 464351 KsGDRsGyssPGsPG X +TTBK1 TTBK1 Q5TCY1 human Tau 281296 P29172 MAPT cow T212 447933 SSPGsPGtPGSRSRT X 25377; 43964; 53001; 49561; 20060; 33032; 30505; 20739; 98160 +TTBK1 TTBK1 Q5TCY1 human Tau 281296 P29172 MAPT cow S411 449082 PVVSGDTsPRHLSNV X 35834; 20194; 98523; 91600; 49562 +TTBK1 TTBK1 Q5TCY1 human Tau iso8 4137 P10636-8 MAPT human S422 449083 GsIDMVDsPQLAtLA X X +TTBK1 TTBK1 Q5TCY1 human Tau iso8 4137 P10636-8 MAPT human S416 454127 sNVsstGsIDMVDsP X 15013; 61160 +Slk SLK O54988 mouse PXN 19303 Q8VI36 Pxn mouse S250 3653284 SsPQRVTsSQQQTRI Paxillin X +Prkg2 PKG2 Q61410 mouse MRVI1 10335 Q9Y6F6 IRAG1 human S689 485352 NMPRRRVsVAVVPKF MRVI1 X +Prkg2 PKG2 Q61410 mouse PKG2 19092 Q61410 Prkg2 mouse S110 450474 LDVHRKtsGLVsLHs X +Prkg2 PKG2 Q61410 mouse PKG2 19092 Q61410 Prkg2 mouse T109 450478 PLDVHRKtsGLVsLH X +Prkg2 PKG2 Q61410 mouse PKG2 19092 Q61410 Prkg2 mouse S126 450477 RGAKAGVsAEPTTRT X +Prkg2 PKG2 Q61410 mouse PKG2 19092 Q61410 Prkg2 mouse S114 450475 RKtsGLVsLHsRRGA X +Prkg2 PKG2 Q61410 mouse PKG2 19092 Q61410 Prkg2 mouse S92 450472 VIHVQGGsPLQAsPD X +Prkg2 PKG2 Q61410 mouse PKG2 19092 Q61410 Prkg2 mouse S117 450473 sGLVsLHsRRGAKAG X +Prkg2 PKG2 Q61410 mouse PKG2 19092 Q61410 Prkg2 mouse S445 450476 KEKVARFsSTSPFQN X +Lyn LYN P25911 mouse Syk 20963 P48025 Syk mouse Y317 447658 STVSFNPyEPtGGPW X 2715 +Lyn LYN P25911 mouse FCGR2A 2212 P12318 FCGR2A human Y304 449552 tDDDKNIyLTLPPND X +Lyn LYN P25911 mouse EPOR 13857 P14753 Epor mouse Y488 457448 DGPySHPyENSLVPD X +Lyn LYN P25911 mouse ZDHHC5 228136 Q8VDZ4 Zdhhc5 mouse Y91 462809 DDFRAPLyKTVEIKG X +Lyn LYN P25911 mouse EPOR 13857 P14753 Epor mouse Y503 449885 SEPLHPGyVACS___ X +Lyn LYN P25911 mouse SHP-1 15170 P29351 Ptpn6 mouse Y564 448912 sKHKEEVyENVHsKS X 8849 +Lyn LYN P25911 mouse TRPV4 63873 Q9EPK8 Trpv4 mouse Y253 448752 IERRCKHyVELLVAQ Ank X X +Lyn LYN P25911 mouse PAG 64019 Q9JM80 Pag1 rat Y381 463949 GEEPEPDyEAIQTLN PAG X +Lyn LYN P25911 mouse DOK2 13449 O70469 Dok2 mouse Y276 452174 LPRPESPySRPHDSL X +Lyn LYN P25911 mouse STAT5A 6776 P42229 STAT5A human Y694 447767 LAkAVDGyVkPQIkQ X 9365; 9356; 9359; 9351; 4322; 9314; 3939; 40284; 5387; 14603; 66740; 51879; 72712 +Lyn LYN P25911 mouse FCER1G 14127 P20491 Fcer1g mouse Y65 451737 REkADAVytGLNTRs ITAM X +Lyn LYN P25911 mouse PKCD 18753 P28867 Prkcd mouse Y332 450077 ILDNNGTyGKIWEGS X +Lyn LYN P25911 mouse p27Kip1 1027 P46527 CDKN1B human Y88 456818 kGsLPEFyyRPPRPP X +Lyn LYN P25911 mouse Syk 20963 P48025 Syk mouse Y342 447659 LPMDTEVyESPyADP X +Lyn LYN P25911 mouse PAG 64019 Q9JM80 Pag1 rat Y409 448996 LVPKENDyESIGDLQ PAG X +Lyn LYN P25911 mouse PAG 64019 Q9JM80 Pag1 rat Y314 450659 EEEISAMysSVNKPG PAG X +Lyn LYN P25911 mouse PAG 94212 Q3U1F9 Pag1 mouse Y386 463949 sEEPEPDyEAIQTLN PAG X X +Lyn LYN P25911 mouse DOK2 13449 O70469 Dok2 mouse Y304 448880 PGAPEGEyAVPFDTV X +Lyn LYN P25911 mouse PHB 18673 P67778 Phb1 mouse Y259 6374000 SRSRNItyLPAGQsV X +Lyn LYN P25911 mouse FCGR2C 9103 P31995 FCGR2C human Y310 449501 tDDDKNIyLTLPPND X +Lyn LYN P25911 mouse FCER1G 14127 P20491 Fcer1g mouse Y76 454847 NTRsQETyEtLkHEk ITAM X +Lyn LYN P25911 mouse DOK2 13449 O70469 Dok2 mouse Y351 447615 APLPDHIyDEPEGVA X 3911 +Lyn LYN P25911 mouse PKCD 18753 P28867 Prkcd mouse Y311 447573 TTEsVGIyQGFEKKP X X 2055 +Lyn LYN P25911 mouse PPP2CA 19052 P63330 Ppp2ca mouse Y307 448571 VTRRtPDyFl_____ X +Lyn LYN P25911 mouse PHB 18673 P67778 Phb1 mouse Y114 6374001 YTsIGEDyDERVLPS Band_7 X +Lyn LYN P25911 mouse SHP-1 15170 P29351 Ptpn6 mouse Y536 448506 QKGQEsEyGNItyPP X +Lyn LYN P25911 mouse LYN 17096 P25911 Lyn mouse Y397 448695 RVIEDNEytAREGAK PK_Tyr_Ser-Thr X X 2101; 6943; 59548; 70926; 78740; 94361; 17320 +Lyn LYN P25911 mouse RAF1 110157 Q99N57 Raf1 mouse Y341 447750 GQRDssyyWEIEASE X +Lyn LYN P25911 mouse Cortactin 13043 Q60598 Cttn mouse Y466 447703 TyTSEPVyETTEAPG X +Lyn LYN P25911 mouse PAG 94212 Q3U1F9 Pag1 mouse Y414 448996 HVPKEsDyEsIGDLQ PAG X X +Lyn LYN P25911 mouse Syk 20963 P48025 Syk mouse Y346 447660 TEVyESPyADPEEIR X 2701; 2717; 14791; 73382; 82975; 31754 +Taok1 TAO1 O88664 rat MARK2 60328 O08679 Mark2 rat T208 449999 TFGNKLDtFCGsPPY Pkinase X X 4836 +MAP3K20 ZAK Q9NYL2 human H3 8350 P68431 H3C1 human S28 455677 ATkAArksAPATGGV Histone X X 9713 +MAP3K20 ZAK Q9NYL2 human ZAK 51776 Q9NYL2 MAP3K20 human T162 455378 sRFHNHttHMsLVGt PK_Tyr_Ser-Thr X X +MAP3K20 ZAK Q9NYL2 human ZAK 51776 Q9NYL2 MAP3K20 human S165 455379 HNHttHMsLVGtFPW PK_Tyr_Ser-Thr X X +MAP3K20 ZAK Q9NYL2 human Chk2 11200 O96017 CHEK2 human T68 447491 SsLEtVstQELYsIP X X 2197; 2661; 28130; 12812; 82263; 64180; 59068 +MAP3K20 ZAK Q9NYL2 human ZAK 51776 Q9NYL2 MAP3K20 human T161 455377 AsRFHNHttHMsLVG PK_Tyr_Ser-Thr X X +MAP3K4 MEKK4 Q9Y6R4 human HOXA10 3206 P31260 HOXA10 human T362 1880104200 FLFNMyLtRERRLEI X X +MAP3K4 MEKK4 Q9Y6R4 human MEKK4 4216 Q9Y6R4 MAP3K4 human T1494 479428 KLKNNAQtMPGEVNS Pkinase X +Prkca PKCA P20444 mouse Vimentin 22352 P20152 Vim mouse S26 451767 GTssRPssNRsYVTT Filament_head X +Prkca PKCA P20444 mouse CD34 12490 Q64314 Cd34 mouse S337 18707502 NGGGQGyssGPGAsP CD34_antigen X +Prkca PKCA P20444 mouse MYBPC1 iso2 109272 G0YZM8 Mybpc1 mouse S204 4738635 IRSAFKRsGEGQEDA X +Prkca PKCA P20444 mouse PRKD1 18760 Q62101 Prkd1 mouse S744 448589 ARIIGEksFRRsVVG Pkinase X 2054 +Prkca PKCA P20444 mouse lamin A/C 16905 P48678 Lmna mouse S5 465449 ___MEtPsQRRAtRs X +Prkca PKCA P20444 mouse CD34 12490 Q64314 Cd34 mouse S343 4733136 yssGPGAsPETQGkA CD34_antigen X +Prkca PKCA P20444 mouse GluR1 14799 P23818 Gria1 mouse S849 448565 FCLIPQQsINEAIRt X 75574 +Prkca PKCA P20444 mouse SHISA7 232813 Q8C3Q5 Shisa7 mouse S417 33636590 LGDGSRAsRYEFTLP X +Prkca PKCA P20444 mouse RAF1 5894 P04049 RAF1 human S497 3082308 AtVksRWsGsQQVEQ PK_Tyr_Ser-Thr X +Prkca PKCA P20444 mouse Ezrin 7430 P15311 EZR human T567 448104 QGRDkyKtLRQIRQG ERM_C X 3141; 3726; 32600 +Prkca PKCA P20444 mouse lamin A/C 16905 P48678 Lmna mouse T416 465451 sQGGGsVtkkRKLEs X +Prkca PKCA P20444 mouse SIK 17691 Q60670 Sik1 mouse S577 465992 FQEGRRAsDTSLTQG X +Prkca PKCA P20444 mouse G-gamma 12 286850 Q28024 GNG12 cow S3 447877 _____MSsKTASTNN X +Prkca PKCA P20444 mouse PLM 56188 Q9Z239 Fxyd1 mouse S88 451425 RssIRRLssRRR___ X +Prkca PKCA P20444 mouse GluR2 14800 P23819 Gria2 mouse S880 448351 yNVyGIEsVKI____ X +Prkca PKCA P20444 mouse HSP27 15507 P14602 Hspb1 mouse S15 448401 FsLLrsPsWEPFRDW X X +Prkca PKCA P20444 mouse KCC2 iso2 57138 Q91V14-2 Slc12a5 mouse S940 487533 ItDEsRGsIRRKNPA SLC12 X X +Prkca PKCA P20444 mouse EGFR 1956 P00533 EGFR human T678 448053 RHIVRKRtLRRLLQE X 14343 +Prkca PKCA P20444 mouse TfR 7037 P02786 TFRC human S24 451671 PLsytRFsLARQVDG X +Prkca PKCA P20444 mouse ER-alpha 13982 P19785 Esr1 mouse S216 12127402 CKAFFKRsIQGHNDY zf-C4 X +Prkca PKCA P20444 mouse TNNI3 21954 P48787 Tnni3 mouse T144 451483 RGKFKRPtLRRVRIs Troponin X +Prkca PKCA P20444 mouse lamin A/C 16905 P48678 Lmna mouse S525 465453 NTWGCGSsLRTALIN LTD X +Prkca PKCA P20444 mouse mGluR7 108073 Q68ED2 Grm7 mouse S862 2846504 NVQKRKRsFKAVVTA X +Prkca PKCA P20444 mouse CBP 12914 P45481 Crebbp mouse S436 447689 CLPLKNAsDKRNQQT X +Prkca PKCA P20444 mouse NRF2 18024 Q60795 Nfe2l2 mouse S40 450082 SREVFDFsQRQKDYE X X +Prkca PKCA P20444 mouse GABRB3 14402 P63080 Gabrb3 mouse S432 450245 KTHLRRRssQLKIKI Neur_chan_memb X +Prkca PKCA P20444 mouse PKCB 18751 P68404 Prkcb mouse T500 447896 WDGVttKtFCGtPDy Pkinase X 9379; 2060; 38938 +Prkca PKCA P20444 mouse Vimentin 22352 P20152 Vim mouse S7 455449 _MSTRsVssssYRRM Filament_head X +Prkca PKCA P20444 mouse Vimentin 22352 P20152 Vim mouse S21 455452 MFGGsGTssRPssNR Filament_head X +Prkca PKCA P20444 mouse lamin A/C 16905 P48678 Lmna mouse S652 465465 RsyLLGNssPRSQSS X +Prkca PKCA P20444 mouse PPP1R1A 58200 Q9ERT9 Ppp1r1a mouse S67 447758 LKSTLsMsPRQRKKM DARPP-32 X +Prkca PKCA P20444 mouse Vimentin 22352 P20152 Vim mouse S10 455451 TRsVssssYRRMFGG Filament_head X +Prkca PKCA P20444 mouse Vimentin 22352 P20152 Vim mouse S34 455454 NRsYVTTsTRTysLG Filament_head X +Prkca PKCA P20444 mouse TNNI3 21954 P48787 Tnni3 mouse S24 448424 APVRRRssANyRAYA Troponin-I_N X +Prkca PKCA P20444 mouse MYBPC1 iso2 109272 G0YZM8 Mybpc1 mouse T84 21560211 NANSQLstLFVEKPQ I-set X +Prkca PKCA P20444 mouse lamin A/C 16905 P48678 Lmna mouse T199 465450 DAENRLQtLkEELDF Filament X +Prkca PKCA P20444 mouse NR2C1 22025 Q505F1 Nr2c1 mouse S568 456552 IGNVRIDsVIPHILK X +Prkca PKCA P20444 mouse PITPNB 56305 P53811 Pitpnb mouse S262 451299 ETMRKKGsVRGTsAA X X +Prkca PKCA P20444 mouse AR 11835 P19091 Ar mouse S794 1875398900 MKALLLFsIIPVDGL Hormone_recep X +Prkca PKCA P20444 mouse Rhodopsin 212541 P15409 Rho mouse S338 448679 DDAsATAsKtEtsQV X +Prkca PKCA P20444 mouse Rhodopsin 212541 P15409 Rho mouse S334 448677 PLGDDDAsATAsKtE X +Prkca PKCA P20444 mouse PKCA 18750 P20444 Prkca mouse S657 448597 QsDFEGFsyVNPQFV Pkinase_C X 9371 +Prkca PKCA P20444 mouse JPH2 59091 Q9ET78 Jph2 mouse S165 4779179 PLRtsLSsLRSEHSN X +Prkca PKCA P20444 mouse GABRB3 14402 P63080 Gabrb3 mouse S433 450246 THLRRRssQLKIKIP Neur_chan_memb X +Prkca PKCA P20444 mouse AQP4 11829 P55088 Aqp4 mouse S180 467301 TIFASCDsKRTDVTG MIP X +Prkca PKCA P20444 mouse NHERF 26941 P70441 Nherf1 mouse S77 957200 ETHQQVVsRIRAALN PDZ X +Prkca PKCA P20444 mouse APPL 26060 Q9UKG1 APPL1 human S430 13204434 ARTSssGsLGSESTN X +Prkca PKCA P20444 mouse Vimentin 22352 P20152 Vim mouse S51 449416 LRPstsRsLysssPG Filament_head X +Prkca PKCA P20444 mouse HSP27 15507 P14602 Hspb1 mouse S86 448403 RALNRQLssGVsEIR X X 2406; 2401; 9709; 11892; 64293 +Prkca PKCA P20444 mouse fascin 14086 Q61553 Fscn1 mouse S39 450888 KVNASAssLkkKQIW Fascin X +Prkca PKCA P20444 mouse STX7 53331 O70439 Stx7 mouse S125 468880 FVARVRAssRVsGGF X +Prkca PKCA P20444 mouse GRK2 25238 P26817 Grk2 rat S29 447724 ATPAARAsKKILLPE X +Prkca PKCA P20444 mouse TNNI3 21954 P48787 Tnni3 mouse S45 450691 KKSKIsAsRKLQLkT X +Prkca PKCA P20444 mouse CD34 12490 Q64314 Cd34 mouse S338 15408590 GGGQGyssGPGAsPE CD34_antigen X +Prkca PKCA P20444 mouse PITPNB 56305 P53811 Pitpnb mouse S165 451298 EDPALFHsVKTKRGP IP_trans X +Prkca PKCA P20444 mouse Vimentin 22352 P20152 Vim mouse S42 451789 TRTysLGsALRPsts Filament_head X +Prkca PKCA P20444 mouse SHISA7 232813 Q8C3Q5 Shisa7 mouse S317 1872500601 STLSCSRsFHNLSHL X +Prkca PKCA P20444 mouse Vimentin 22352 P20152 Vim mouse S25 455453 sGTssRPssNRsYVT Filament_head X +Prkca PKCA P20444 mouse PPFIA3 140591 Q91Z79 Ppfia3 rat S760 1873117000 HKAPKRKsIKssIGR X X +Prkca PKCA P20444 mouse PKCA 18750 P20444 Prkca mouse T497 448598 MDGVttRtFCGtPDy Pkinase X 9379; 2060; 38938 +Prkca PKCA P20444 mouse GJA1 24392 P08050 Gja1 rat S368 447813 QRPssRAssRAssRP X 3511; 52559 +Prkca PKCA P20444 mouse Vimentin 22352 P20152 Vim mouse S39 451766 TTsTRTysLGsALRP Filament_head X 13614 +Prkca PKCA P20444 mouse KCNE1 25471 P15383 Kcne1 rat S103 10349700 FQARVLEsFRACYVI ISK_Channel X +Prkca PKCA P20444 mouse TMPO 21917 Q61029 Tmpo mouse S179 451480 RQNGsNDsDRysDND X +Prkca PKCA P20444 mouse NPHS1 54631 Q9QZS7 Nphs1 mouse T1139 18507017 QWtGDRDtRSSTVST X +Prkca PKCA P20444 mouse NPHS1 54631 Q9QZS7 Nphs1 mouse T1134 18507016 EYEESQWtGDRDtRS X +Prkca PKCA P20444 mouse CREM 12916 P27699 Crem mouse S133 448412 EILSRRPsYRKILNE pKID X 4095; 14228; 14001 +Prkca PKCA P20444 mouse SNAP-25 20614 P60879 Snap25 mouse S187 448668 RIMEkADsNkTRIDE X +Prkca PKCA P20444 mouse GluR1 14799 P23818 Gria1 mouse T858 3362100 NEAIRtstLPRNsGA X X +Prkca PKCA P20444 mouse TNNI3 21954 P48787 Tnni3 mouse S23 448423 PAPVRRRssANyRAY Troponin-I_N X +Prkca PKCA P20444 mouse AYTL1 270084 Q8BYI6 Lpcat2 mouse S34 15146101 PMVPRQAsFFPPPVP X +Prkca PKCA P20444 mouse DLX3 13393 Q64205 Dlx3 mouse S138 455813 KPRTIYSsYQLAALQ Homeodomain X +Prkca PKCA P20444 mouse Vimentin 22352 P20152 Vim mouse S66 451765 GAyVtRssAVRLRss Filament_head X +Prkca PKCA P20444 mouse Akt1 11651 P31750 Akt1 mouse S473 447855 RPHFPQFsysAsGtA Pkinase_C X 9271; 3787; 4060; 4051; 5102; 4058; 2336; 2337; 4075; 4070; 5012; 4071; 92982; 5315; 9563; 9018; 12694; 52240; 11962; 15116; 88106; 26580; 68035; 31957; 23430; 20235 +Prkca PKCA P20444 mouse RAF1 5894 P04049 RAF1 human S619 5822317 sLPKINRsAsEPsLH X +Prkca PKCA P20444 mouse lamin A/C 16905 P48678 Lmna mouse T480 465452 NGDDPLMtYRFPPKF LTD X +Prkca PKCA P20444 mouse PEA-15 18611 Q62048 Pea15 mouse S104 455750 TkLtRIPsAKKyKDI X X 2776 +Prkca PKCA P20444 mouse CD34 12490 Q64314 Cd34 mouse S371 18707501 ATSRNGHsARQHVVA CD34_antigen X +Prkca PKCA P20444 mouse MYBPC1 iso2 109272 G0YZM8 Mybpc1 mouse S83 21560212 QNANSQLstLFVEKP X +Prkca PKCA P20444 mouse NR2C1 22025 Q505F1 Nr2c1 mouse S461 456551 MSPERRKsLMEHIFK Hormone_recep X +Prkca PKCA P20444 mouse Vimentin 22352 P20152 Vim mouse S9 455450 STRsVssssYRRMFG Filament_head X +Prkca PKCA P20444 mouse TNNI3 21954 P48787 Tnni3 mouse S43 450690 AkKKSKIsAsRKLQL X +Prkca PKCA P20444 mouse IRS1 25467 P35570 Irs1 rat S24 455604 GYLRKPKsMHKRFFV PH X +Prkca PKCA P20444 mouse KLHL3 100503085 E0CZ16 Klhl3 mouse S433 36440206 PMNTRRSsVGVGVVE Kelch_1 X +Prkca PKCA P20444 mouse CD34 12490 Q64314 Cd34 mouse S313 18707500 YFLMNRRsWSPTGER CD34_antigen X +Prkca PKCA P20444 mouse TDG 21665 P56581 Tdg mouse S99 11509300 TSkksGksTKSKEKQ X X +Prkca PKCA P20444 mouse TDG 21665 P56581 Tdg mouse S96 11509301 KPATSkksGksTKSK X X +Prkca PKCA P20444 mouse RXRA 20181 P28700 Rxra mouse T167 1868546605 CKGFFKRtVRKDLTY zf-C4 X +Prkca PKCA P20444 mouse GluR2 29627 P19491 Gria2 rat S880 448351 yNVyGIEsVkI____ X +Stk39 STLK3 Q9Z1W9 mouse NCCT 20497 P59158 Slc12a3 mouse T58 469617 MRtFGYNtIDVVPAY AA_permease_N X +Stk39 STLK3 Q9Z1W9 mouse STLK3 53416 Q9Z1W9 Stk39 mouse T247 458885 VRKtFVGtPCWMAPE Pkinase X +Stk39 STLK3 Q9Z1W9 mouse STLK3 53416 Q9Z1W9 Stk39 mouse T243 456505 tRNKVRKtFVGtPCW Pkinase X +Ptk2 FAK P34152 mouse YAP1 10413 P46937 YAP1 human S397 3190672 tyHSRDEstDsGLsM X +Ptk2 FAK P34152 mouse FAK 14083 P34152 Ptk2 mouse Y397 447887 sVsEtDDyAEIIDEE X 3283; 8556 +Ptk2 FAK P34152 mouse TAK1 26409 Q62073 Map3k7 mouse S412 455196 NGQPRRRsIQDLtVT X 9339 +Ptk2 FAK P34152 mouse EphA2 13836 Q03145 Epha2 mouse Y773 450861 EDDPEAtyTtsGGKI PK_Tyr_Ser-Thr X 8244; 8862 +Ptk2 FAK P34152 mouse GSK3B 56637 Q9WV60 Gsk3b mouse Y216 448569 RGEPNVsyICsRYYR Pkinase X +Prkaca PKACA P05132 mouse MYBPC1 iso2 109272 G0YZM8 Mybpc1 mouse S204 4738635 IRSAFKRsGEGQEDA X +Prkaca PKACA P05132 mouse HSP20 243912 Q5EBG6 Hspb6 mouse S16 450706 PsWLRRAsAPLPGFS Crystallin X 36519 +Prkaca PKACA P05132 mouse FLNC 68794 Q8VHX6 Flnc mouse S2625 15403523 sSSsRGAsySSIPKF X +Prkaca PKACA P05132 mouse HSL 16890 P54310 Lipe mouse S557 448803 PtESMRRsVsEAALA X 4139 +Prkaca PKACA P05132 mouse MARCKS 17118 P26645 Marcks mouse S160 466360 FKKsFkLsGFsFKKs MARCKS X 8722 +Prkaca PKACA P05132 mouse Spinophilin 217124 Q6R891 Ppp1r9b mouse S94 448728 SDRGVRLsLPRAssL X +Prkaca PKACA P05132 mouse SHISA7 232813 Q8C3Q5 Shisa7 mouse T366 1872500602 QLEMPRGtLPLHALR X +Prkaca PKACA P05132 mouse GluR1 14799 P23818 Gria1 mouse S849 448565 FCLIPQQsINEAIRt X 75574 +Prkaca PKACA P05132 mouse SHISA7 232813 Q8C3Q5 Shisa7 mouse S417 33636590 LGDGSRAsRYEFTLP X +Prkaca PKACA P05132 mouse AMPKA1 105787 Q5EG47 Prkaa1 mouse S496 450431 AtPQRsGsIsNYRsC AdenylateSensor X 4185; 4184; 2537 +Prkaca PKACA P05132 mouse CRMP-2 12934 O08553 Dpysl2 mouse T555 448084 DNIPRRttQRIVAPP X +Prkaca PKACA P05132 mouse HSL 3991 Q05469 LIPE human S951 450195 GFHPRRssQGAtQMP Abhydrolase_3 X +Prkaca PKACA P05132 mouse nAChRA7 11441 P49582 Chrna7 mouse S365 451182 QHKPRRCsLASVELS Neur_chan_memb X +Prkaca PKACA P05132 mouse smMLCK 396445 P11799 MYLK chicken S140 41411900 KTPGGRLsVPPVEHR X +Prkaca PKACA P05132 mouse PTRF 19285 O54724 Cavin1 mouse S368 452129 tDLLRGssPDVHtLL X +Prkaca PKACA P05132 mouse IP3R1 16438 P11881 Itpr1 mouse S1588 450681 RNAARRDsVLAAsRD X +Prkaca PKACA P05132 mouse NFAT2 4772 O95644 NFATC1 human S245 448861 PSTsPRAsVTEEsWL X +Prkaca PKACA P05132 mouse LDB3 24131 Q9JKS4 Ldb3 mouse S265 10364530 DEWARRSsNLQSRSF DUF4749 X +Prkaca PKACA P05132 mouse perilipin 1 25629 P43884 Plin1 rat S277 450081 QVVSRRQsEVRVPWL Perilipin X +Prkaca PKACA P05132 mouse GJD2 14617 O54851 Gjd2 mouse S293 471387 GAQAKRKsVYEIRNK X +Prkaca PKACA P05132 mouse SIK 17691 Q60670 Sik1 mouse S577 465992 FQEGRRAsDTSLTQG X +Prkaca PKACA P05132 mouse MLPH 171531 Q91V27 Mlph mouse S498 7103618 sGKPRRKsGIPIFLP Rab_eff_C X +Prkaca PKACA P05132 mouse GluR1 14799 P23818 Gria1 mouse S863 448566 tstLPRNsGAGASGG X X 8084 +Prkaca PKACA P05132 mouse PLCL1 227120 Q3USB7 Plcl1 mouse T94 453436 KCGGRKKtVsFSSMP X +Prkaca PKACA P05132 mouse perilipin 1 25629 P43884 Plin1 rat S81 450079 EPVVRRLsTQFTAAN Perilipin X +Prkaca PKACA P05132 mouse SLC29A1 63959 Q9JIM1 Slc29a1 mouse S266 21326703 PKGRREEsGVPGPNs Nucleoside_tran X +Prkaca PKACA P05132 mouse CITED1 12705 P97769 Cited1 mouse S79 8112774 GsPTATPssKPPsFN CITED X +Prkaca PKACA P05132 mouse MARCKS 17118 P26645 Marcks mouse S163 451837 sFkLsGFsFKKsKKE MARCKS X 8722 +Prkaca PKACA P05132 mouse NMDAR2B 14812 Q01097 Grin2b mouse Y1472 448167 GSSNGHVyEKLSSIE NMDAR2_C X 4208 +Prkaca PKACA P05132 mouse NFAT2 4772 O95644 NFATC1 human S269 448862 PCNKRKYsLNGRQPP X +Prkaca PKACA P05132 mouse KIFAP3 16579 P70188 Kifap3 mouse S102 18260847 YLQNRRDsLPGKEKK KAP X +Prkaca PKACA P05132 mouse ABHD5 67469 Q9DBL9 Abhd5 mouse S239 36744500 PDFKRKYsSMFEDDT X +Prkaca PKACA P05132 mouse RAF1 110157 Q99N57 Raf1 mouse S233 448651 AsSQHRYstPHAFTF X +Prkaca PKACA P05132 mouse SLC29A1 63959 Q9JIM1 Slc29a1 mouse S281 21326706 PPtNRNQsIKAILKs Nucleoside_tran X +Prkaca PKACA P05132 mouse ARPP-21 74100 Q9DCB4 Arpp21 mouse S57 448050 QERRKsksGAGkGkL X X +Prkaca PKACA P05132 mouse perilipin 1 103968 Q8CGN5 Plin1 mouse S492 459628 EKPARRVsDsFFRPs X +Prkaca PKACA P05132 mouse SNAP-25 20614 P60879 Snap25 mouse T138 449875 GGFIRRVtNDARENE SNAP-25 X +Prkaca PKACA P05132 mouse CDC25B 12531 P30306 Cdc25b mouse S321 448409 QRLFRsPsMPCSVIR M-inducer_phosp X +Prkaca PKACA P05132 mouse HSP27 15507 P14602 Hspb1 mouse S15 448401 FsLLrsPsWEPFRDW X X +Prkaca PKACA P05132 mouse PPP2R5D 21770 Q7TNL5 Ppp2r5d mouse S68 457389 QLSKIKYsGGPQIVK X +Prkaca PKACA P05132 mouse SPTBN1 20742 Q62261 Sptbn1 mouse T346 451391 QQLQAFNtYRTVEKP Spectrin X +Prkaca PKACA P05132 mouse ARHGAP14 259302 Q812A2 Srgap3 mouse S858 3175109 MGRVRLRsDGAAIPR X +Prkaca PKACA P05132 mouse TIAM2 24001 Q6ZPF3 Tiam2 mouse S782 19003600 KGREKRAsITQMFDS X +Prkaca PKACA P05132 mouse RASGRF1 19417 P27671 Rasgrf1 mouse S822 450230 LSASRKHsSDVLKEE X +Prkaca PKACA P05132 mouse HDAC4 9759 P56524 HDAC4 human S265 4737971 QKVAERRssPLLRRK X +Prkaca PKACA P05132 mouse GABRA2 14395 P26048 Gabra2 mouse S359 1869636101 DKKKEKGsVMIQNNA X X +Prkaca PKACA P05132 mouse STMN1 3925 P16949 STMN1 human S63 448557 AAEERRksHEAEVLk Stathmin X +Prkaca PKACA P05132 mouse melanopsin 30044 Q9QXZ9 Opn4 mouse T186 26415701 GRGsKRRtALVLLGV 7tm_1 X +Prkaca PKACA P05132 mouse SHISA7 232813 Q8C3Q5 Shisa7 mouse S405 3989799 PNPRRVMsQEHLLGD X +Prkaca PKACA P05132 mouse HDAC4 9759 P56524 HDAC4 human S266 4737976 KVAERRssPLLRRKD X +Prkaca PKACA P05132 mouse COX4I1 12857 P19783 Cox4i1 mouse S58 479944 HVTMLsAsQkALKEk COX4 X +Prkaca PKACA P05132 mouse LDB3 24131 Q9JKS4 Ldb3 mouse S296 28850313 EEALRRSsTPIEHAP X +Prkaca PKACA P05132 mouse MYBPC3 17868 O70468 Mybpc3 mouse T65 30324203 AAEGkRHtLTVRDAs I-set X +Prkaca PKACA P05132 mouse SIRT1 93759 Q923E4 Sirt1 mouse S434 22568200 LLIVIGSsLKVRPVA SIR2 X +Prkaca PKACA P05132 mouse PTP-SL iso2 19279 Q62132-2 Ptprr mouse S231 31949800 GLQERRGsNVSLTLD X +Prkaca PKACA P05132 mouse SLC43A2 215113 Q8CGA3 Slc43a2 mouse S274 2508983 TTVGRRLsVGssMRt MFS_1 X +Prkaca PKACA P05132 mouse Fos 14281 P01101 Fos mouse S362 448481 AAAHRKGsSSNEPSS X +Prkaca PKACA P05132 mouse PPP2R5D 21770 Q7TNL5 Ppp2r5d mouse S566 457390 KVLLRRKsELPQDVy X +Prkaca PKACA P05132 mouse SHISA7 232813 Q8C3Q5 Shisa7 mouse S430 480319 LPRARLVsQEHLLLs X +Prkaca PKACA P05132 mouse MOS 17451 P00536 Mos mouse S25 448659 SVDSRSCsIPLVAPR X X +Prkaca PKACA P05132 mouse BAD 12015 Q61337 Bad mouse S112 447860 ETRsRHssyPAGtEE Bcl-2_BAD X X 9291; 5284; 9296; 5193; 11865; 94223 +Prkaca PKACA P05132 mouse PPP1R1A 58200 Q9ERT9 Ppp1r1a mouse T35 447759 QIRRRRPtPATLVLt DARPP-32 X +Prkaca PKACA P05132 mouse APOBEC3G 60489 Q9HC16 APOBEC3G human T218 21656100 WVRGRHEtyLCYEVE NAD2 X +Prkaca PKACA P05132 mouse RAF1 5894 P04049 RAF1 human S259 447741 sQRQRststPNVHMV X 9421; 20011 +Prkaca PKACA P05132 mouse CDK18 18557 Q04899 Cdk18 mouse S66 2192678 RQNQRRFsMEDLNKR X X +Prkaca PKACA P05132 mouse H1E 3008 P10412 H1-4 human S36 456059 GAAkRkAsGPPVsEL X +Prkaca PKACA P05132 mouse MYBPC3 17868 O70468 Mybpc3 mouse S47 4699355 VRWQRDGsDItANDK I-set X +Prkaca PKACA P05132 mouse NLRP3 114548 Q96P20 NLRP3 human S295 57761902 HKIVRKPsRILFLMD NACHT X +Prkaca PKACA P05132 mouse MYBPC1 iso2 109272 G0YZM8 Mybpc1 mouse S59 21560210 RALERKDsEWsLGES X +Prkaca PKACA P05132 mouse PKACA 18747 P05132 Prkaca mouse S339 449886 EEEEIRVsINEKCGK X +Prkaca PKACA P05132 mouse STEP 19259 P54830 Ptpn5 mouse S221 448294 GLQERRGsNVSLTLD X 5659 +Prkaca PKACA P05132 mouse Vimentin 22352 P20152 Vim mouse S7 455449 _MSTRsVssssYRRM Filament_head X +Prkaca PKACA P05132 mouse ASK1 26408 O35099 Map3k5 mouse S973 447736 NEYLRSIsLPVPVLV X 3764 +Prkaca PKACA P05132 mouse PLCL1 227120 Q3USB7 Plcl1 mouse S96 453437 GGRKKtVsFSSMPSE X +Prkaca PKACA P05132 mouse perilipin 1 103968 Q8CGN5 Plin1 mouse S517 471365 YsQLRKKs_______ X +Prkaca PKACA P05132 mouse CDC25B 12531 P30306 Cdc25b mouse S149 7998663 FTIKRFRsLPVRLLE M-inducer_phosp X +Prkaca PKACA P05132 mouse BANP 53325 Q8VBU8 Banp mouse S347 475059 SFSRRTPsSSSYSAS X +Prkaca PKACA P05132 mouse ATF-4 11911 Q06507 Atf4 mouse S218 448436 DTPSDNDsGICMSPE X +Prkaca PKACA P05132 mouse AurC 20871 O88445 Aurkc mouse T171 455456 TPSLRRKtMCGtLDY Pkinase X 2914; 13464; 8525 +Prkaca PKACA P05132 mouse PPP1R3A 100009140 Q00756 RG1 rabbit S48 449320 PQPSRRGsESSEEVY X +Prkaca PKACA P05132 mouse LKB1 20869 Q9WTK7 Stk11 mouse S431 448147 sNKIRRLsACKQQ__ X X 3482 +Prkaca PKACA P05132 mouse MYBPC3 295929 P56741 Mybpc3 rat S279 471079 RSAFRRTsLAGTGRR X X +Prkaca PKACA P05132 mouse MARCKS 17118 P26645 Marcks mouse S152 447786 kkKKKRFsFKKsFkL MARCKS X 2741; 11992 +Prkaca PKACA P05132 mouse ARX 11878 O35085 Arx mouse S266 1869973800 LKEPRRCsVATTGTV X +Prkaca PKACA P05132 mouse USP20 74270 Q8C6M1 Usp20 mouse S334 7323248 RMKDRKFsWGQQRTN X +Prkaca PKACA P05132 mouse PLB 18821 P61014 Pln mouse T17 448115 SAIRRAstIEMPQQA Phospholamban X 8496 +Prkaca PKACA P05132 mouse AKAP9 10142 Q99996 AKAP9 human S43 456204 QkKKRKTsSsKHDVS X +Prkaca PKACA P05132 mouse Kv4.2 16508 Q9Z0V2 Kcnd2 mouse S552 450462 VsGsHRGsVQELSTI X X +Prkaca PKACA P05132 mouse SLC29A1 63959 Q9JIM1 Slc29a1 mouse S288 21326707 sIKAILKsICVPALS Nucleoside_tran X +Prkaca PKACA P05132 mouse TNNI3 21954 P48787 Tnni3 mouse S24 448424 APVRRRssANyRAYA Troponin-I_N X X +Prkaca PKACA P05132 mouse TPH1 100009100 P17290 TPH1 rabbit S58 451575 RKSKRRNsEFEIFVD X +Prkaca PKACA P05132 mouse PLB 18821 P61014 Pln mouse S16 448114 RSAIRRAstIEMPQQ Phospholamban X 8496 +Prkaca PKACA P05132 mouse Lasp-1 16796 Q61792 Lasp1 mouse T156 454432 SSSYRRPtEQQQPQP X +Prkaca PKACA P05132 mouse WEE1B 381759 Q66JT0 Wee2 mouse S15 456697 QGLNKKLsFSFCEED X +Prkaca PKACA P05132 mouse GLUL 14645 P15105 Glul mouse S343 467948 yFEDRRPsANCDPYA X X +Prkaca PKACA P05132 mouse HSL 16890 P54310 Lipe mouse S559 448804 ESMRRsVsEAALAQP X 4137 +Prkaca PKACA P05132 mouse HNF4 alpha 15378 P49698 Hnf4a mouse S143 458369 RIStRRssYEDSsLP X +Prkaca PKACA P05132 mouse MOS 17451 P00536 Mos mouse S71 450039 CLMHRLGsGGFGSVY Pkinase X X +Prkaca PKACA P05132 mouse SHISA7 232813 Q8C3Q5 Shisa7 mouse S306 19014882 AMPPPsPsLHYSTLS X +Prkaca PKACA P05132 mouse RAF1 5894 P04049 RAF1 human S621 447746 PKINRsAsEPsLHRA X X +Prkaca PKACA P05132 mouse QIK 235344 Q8CFH6 Sik2 mouse S587 3212040 FREGRRAsDtsLTQG X +Prkaca PKACA P05132 mouse QSK 70661 Q6P4S6 Sik3 mouse S609 1868968411 QRYLANRsKRHTLAM X +Prkaca PKACA P05132 mouse BAD 12015 Q61337 Bad mouse S155 447863 GRELRRMsDEFEGsF Bcl-2_BAD X X 9297 +Prkaca PKACA P05132 mouse melanopsin 30044 Q9QXZ9 Opn4 mouse S287 26415700 RQWQRLQsEWKMAKV 7tm_1 X +Prkaca PKACA P05132 mouse perilipin 5 66968 Q8BVZ1 Plin5 mouse S155 8095494 AQRGRRWsGELRRsM Perilipin X X +Prkaca PKACA P05132 mouse NHERF 26941 P70441 Nherf1 mouse S77 957200 ETHQQVVsRIRAALN PDZ X +Prkaca PKACA P05132 mouse Vimentin 22352 P20152 Vim mouse S51 449416 LRPstsRsLysssPG Filament_head X +Prkaca PKACA P05132 mouse PKACA 18747 P05132 Prkaca mouse T198 448459 RVKGRtWtLCGtPEY Pkinase X 4781; 5661 +Prkaca PKACA P05132 mouse HSP27 15507 P14602 Hspb1 mouse S86 448403 RALNRQLssGVsEIR X X 2406; 2401; 9709; 11892; 64293 +Prkaca PKACA P05132 mouse RHOA 387 P61586 RHOA human S188 449035 ARRGKKKsGCLVL__ X X +Prkaca PKACA P05132 mouse Kv4.2 16508 Q9Z0V2 Kcnd2 mouse T38 450461 PRQERKRtQDALIVL X X +Prkaca PKACA P05132 mouse CACNA1C iso5 12288 Q0PCR6 Cacna1c mouse S1927 455278 ASLGRRAsFHLECLK CAC1F_C X +Prkaca PKACA P05132 mouse DARPP-32 19049 Q60829 Ppp1r1b mouse T34 448047 MIRRRRPtPAMLFRV DARPP-32 X X 12438 +Prkaca PKACA P05132 mouse CAMK1D iso2 227541 Q8BW96-2 Camk1d mouse S349 7101531 SFLLRRGsQESELRG X X +Prkaca PKACA P05132 mouse GJD2 14617 O54851 Gjd2 mouse S315 471389 PNFGRTQsSDSAYV_ X +Prkaca PKACA P05132 mouse AQP0 17339 P51180 Mip mouse S235 450116 KSVSERLsILKGARP X +Prkaca PKACA P05132 mouse NLGN1 192167 Q99K10 Nlgn1 mouse S839 1868546601 HPHPHSHsTTRV___ X X +Prkaca PKACA P05132 mouse CREB 1385 P16220 CREB1 human S119 448228 EILsRRPsyRkILND pKID X X 9187; 9196; 9198; 4095; 14228; 14001; 39561; 80120; 44864; 54960; 95995 +Prkaca PKACA P05132 mouse MOS 17451 P00536 Mos mouse S232 450040 DLRCRQAsPHHIGGT Pkinase X X +Prkaca PKACA P05132 mouse ADAM22 11496 Q9R1V6 Adam22 mouse S855 469109 RFRPRsNsTEtLsPA X +Prkaca PKACA P05132 mouse MYBPC3 17868 O70468 Mybpc3 mouse S282 471080 AGAGRRtsDsHEDAG X +Prkaca PKACA P05132 mouse KCNK18 332396 Q6VV64 Kcnk18 mouse S264 2712200 RPVERSNsCPELVLG X +Prkaca PKACA P05132 mouse TRPC6 22068 Q61143 Trpc6 mouse S28 22280200 AGTRRNEsQDYLLMD X +Prkaca PKACA P05132 mouse PKD1 18763 O08852 Pkd1 mouse S4159 457387 PSRSSRGsKSSPVVL X +Prkaca PKACA P05132 mouse RASGRF1 19417 P27671 Rasgrf1 mouse S745 450229 PsRRRKLsLNIPIIT RasGEF_N X +Prkaca PKACA P05132 mouse NFkB-p65 19697 Q04207 Rela mouse S276 447798 SMQLRRPsDRELSEP RHD_dimer X X +Prkaca PKACA P05132 mouse CHCHD3 66075 Q9CRB9 Chchd3 mouse T11 4038300 TASTRRVtFEADENE X +Prkaca PKACA P05132 mouse SHISA7 232813 Q8C3Q5 Shisa7 mouse S317 1872500601 STLSCSRsFHNLSHL X +Prkaca PKACA P05132 mouse ASK1 26408 O35099 Map3k5 mouse S993 7449405 SSEYGSVsPDTELKA X +Prkaca PKACA P05132 mouse GATA4 54254 P46152 Gata4 rat S261 450013 IKPQRRLsASRRVGL X +Prkaca PKACA P05132 mouse HSL 16890 P54310 Lipe mouse S651 450195 GFHPRRssQGVLHMP Abhydrolase_3 X 4126; 45804 +Prkaca PKACA P05132 mouse PGC-1 alpha 19017 O70343 Ppargc1a mouse S241 13861602 KCASKKKsHTQPQSQ X +Prkaca PKACA P05132 mouse NFM 18040 P08553 Nefm mouse S23 452024 RVTEtRSsFSrVsGs Filament_head X +Prkaca PKACA P05132 mouse PTRF 19285 O54724 Cavin1 mouse S171 485274 LPAkLsVsksLkEsE PTRF_SDPR X +Prkaca PKACA P05132 mouse CSF2RB 1439 P32927 CSF2RB human S601 448463 LGPPHSRsLPDILGQ X X +Prkaca PKACA P05132 mouse melanopsin 30044 Q9QXZ9 Opn4 mouse S182 26415702 LATIGRGsKRRtALV 7tm_1 X +Prkaca PKACA P05132 mouse smMLCK 396445 P11799 MYLK chicken S149 17555039 PPVEHRPsIWGESPP X +Prkaca PKACA P05132 mouse BNIP3 12176 O55003 Bnip3 mouse T181 41388500 IYIGRRLtTSTSTF_ BNIP3 X +Prkaca PKACA P05132 mouse RAF1 5894 P04049 RAF1 human S43 447744 FGyQRRAsDDGKLtD X +Prkaca PKACA P05132 mouse SNAPIN 20615 Q9Z266 Snapin mouse S50 448453 HVHAVREsQVELREQ Snapin_Pallidin X +Prkaca PKACA P05132 mouse MEF2D 17261 Q63943 Mef2d mouse S190 2246701 QPALQRNsVsPGLPQ X +Prkaca PKACA P05132 mouse AIDA 108909 Q8C4Q6 Aida mouse S161 15495718 TLLPRLPsEPGMtLL Aida_C2 X X +Prkaca PKACA P05132 mouse MYBPC3 17868 O70468 Mybpc3 mouse T290 4699397 DsHEDAGtPDFSsLL X +Prkaca PKACA P05132 mouse Vimentin 22352 P20152 Vim mouse S25 455453 sGTssRPssNRsYVT Filament_head X +Prkaca PKACA P05132 mouse PLCL1 5334 Q15111 PLCL1 human T246 467202 PRFMWLKtVFEAADV X +Prkaca PKACA P05132 mouse MYBPC1 iso2 109272 G0YZM8 Mybpc1 mouse S62 21560209 ERKDsEWsLGESPAG X +Prkaca PKACA P05132 mouse Kir6.2 16514 Q61743 Kcnj11 mouse T224 453090 MQVVRKTtSPEGEVV IRK_C X +Prkaca PKACA P05132 mouse TEAD1 21676 P30051 Tead1 mouse S102 450655 QVLARRKsRDFHSKL X X +Prkaca PKACA P05132 mouse Vimentin 22352 P20152 Vim mouse S39 451766 TTsTRTysLGsALRP Filament_head X 13614 +Prkaca PKACA P05132 mouse PPP1R3A 140491 Q99MR9 Ppp1r3a mouse S67 449321 TSASRRVsFADsLGF X +Prkaca PKACA P05132 mouse PPP2R5D 21770 Q7TNL5 Ppp2r5d mouse S53 457388 PssNKRPsNStPPPT X +Prkaca PKACA P05132 mouse CEACAM1 81613 P16573 Ceacam1 rat S449 22636602 ALAYFLYsRKTGGGS X +Prkaca PKACA P05132 mouse PHLPP2 244650 Q8BXA7 Phlpp2 mouse S1116 17546653 PRPERRCsLHPASsA X +Prkaca PKACA P05132 mouse CREM 12916 P27699 Crem mouse S133 448412 EILSRRPsYRKILNE pKID X 4095; 14228; 14001 +Prkaca PKACA P05132 mouse HSL 3991 Q05469 LIPE human S853 448803 IAEPMRRsVsEAALA X 4139 +Prkaca PKACA P05132 mouse GJD2 14617 O54851 Gjd2 mouse S306 471388 NKDLPRVsVPNFGRT X +Prkaca PKACA P05132 mouse SNAPIN 295217 P60192 Snapin rat S50 448453 HVHAVREsQVELREQ Snapin_Pallidin X +Prkaca PKACA P05132 mouse NF-E2 18022 Q07279 Nfe2 mouse S170 450012 MEAGRRRsEYVDMYP X X +Prkaca PKACA P05132 mouse MEF2D 17261 Q63943 Mef2d mouse S121 2246700 EDKYRRAsEELDGLF HJURP_C X +Prkaca PKACA P05132 mouse NFkB-p65 5970 Q04206 RELA human S276 447798 sMQLRRPsDRELsEP RHD_dimer X +Prkaca PKACA P05132 mouse FLNA 2316 P21333 FLNA human S2152 451357 tRRRRAPsVANVGsH Filamin X 4761 +Prkaca PKACA P05132 mouse RYR2 20191 E9Q401 Ryr2 mouse S2807 448848 YNRTRRIsQtsQVsI X +Prkaca PKACA P05132 mouse QSK 70661 Q6P4S6 Sik3 mouse S551 468543 GPLGRRAsDGGANIQ X +Prkaca PKACA P05132 mouse RARA 19401 P11416 Rara mouse S369 451381 YVRKRRPsRPHMFPK Hormone_recep X X +Prkaca PKACA P05132 mouse CDK18 18557 Q04899 Cdk18 mouse S12 2192675 KNFKRRLsLSVPRPE X X +Prkaca PKACA P05132 mouse TNNI3 21954 P48787 Tnni3 mouse S23 448423 PAPVRRRssANyRAY Troponin-I_N X X +Prkaca PKACA P05132 mouse MYBPC3 17868 O70468 Mybpc3 mouse S302 471081 sLLKKRDsFRRDskL X +Prkaca PKACA P05132 mouse Doublecortin 13193 O88809 Dcx mouse S47 451112 TRTLQALsNEKKAKK X X +Prkaca PKACA P05132 mouse MARCKS 17118 P26645 Marcks mouse S156 447787 KRFsFKKsFkLsGFs MARCKS X 2741; 11992 +Prkaca PKACA P05132 mouse ADAM22 11496 Q9R1V6 Adam22 mouse S832 469108 NGRPRsNsWQGNMGG X +Prkaca PKACA P05132 mouse Vimentin 22352 P20152 Vim mouse S66 451765 GAyVtRssAVRLRss Filament_head X +Prkaca PKACA P05132 mouse HSL 3991 Q05469 LIPE human S855 448804 EPMRRsVsEAALAQP X 4137 +Prkaca PKACA P05132 mouse CDK18 18557 Q04899 Cdk18 mouse S109 468386 TRMSRRAsLsDIGFG X X +Prkaca PKACA P05132 mouse SLC29A1 63959 Q9JIM1 Slc29a1 mouse S273 21326704 sGVPGPNsPPtNRNQ Nucleoside_tran X +Prkaca PKACA P05132 mouse HPK1 26411 P70218 Map4k1 mouse S171 455474 ATLARRLsFIGTPYW Pkinase X +Prkaca PKACA P05132 mouse Vimentin 22352 P20152 Vim mouse S47 455455 LGsALRPstsRsLys Filament_head X +Prkaca PKACA P05132 mouse PPM1H 319468 Q3UYC0 Ppm1h mouse S123 479930 RNsKRRssLPNGEGL X X +Prkaca PKACA P05132 mouse SLC23A2 54338 Q9EPR4 Slc23a2 mouse S640 483980 KSENSRSsDKDsQAt X X +Prkaca PKACA P05132 mouse SHISA7 232813 Q8C3Q5 Shisa7 mouse S340 1872500600 kSELNRYsSLKRLAE X +Prkaca PKACA P05132 mouse 5-LO 240 P09917 ALOX5 human S524 452140 GMRGRKSsGFPkSVK Lipoxygenase X X +Prkaca PKACA P05132 mouse MYBPC3 295929 P56741 Mybpc3 rat S307 471081 SSLLKKSsFRRDsKL X X +Prkaca PKACA P05132 mouse PTRF 19285 O54724 Cavin1 mouse T304 2566127 DKLRksFtPDHVVyA PTRF_SDPR X +Prkaca PKACA P05132 mouse TIAM2 24001 Q6ZPF3 Tiam2 mouse S1562 19003601 VAESRRDsKSTELEK X +Prkaca PKACA P05132 mouse Merlin 18016 P46662 Nf2 mouse S518 448282 DTDMKRLsMEIEKEK ERM_C X X 9163; 13281 +Prkaca PKACA P05132 mouse GABRB1 14400 P50571 Gabrb1 mouse S409 451812 IQyRKPLssREGFGR Neur_chan_memb X +Prkaca PKACA P05132 mouse MYBPC3 17868 O70468 Mybpc3 mouse S307 2846505 RDsFRRDskLEAPAE X +Prkaca PKACA P05132 mouse JMJD3 216850 Q5NCY0 Kdm6b mouse T1044 1867766700 GGVsKVKtPTAPAPP X X +Prkaca PKACA P05132 mouse MYBPC3 17868 O70468 Mybpc3 mouse S105 17660717 APPEkAEsEVAPGAP X +Prkaca PKACA P05132 mouse IP3R1 16438 P11881 Itpr1 mouse S1755 450682 RPSGRREsLtsFGNG X 3760; 8548 +Prkaca PKACA P05132 mouse TIAM2 24001 Q6ZPF3 Tiam2 mouse T749 15503728 DSTLRKRtLsLTQRG X X +Prkaca PKACA P05132 mouse NLRP3 216799 Q8R4B8 Nlrp3 mouse S291 57761902 CKILRKPsRILFLMD NACHT X +Prkaca PKACA P05132 mouse Restin 65201 Q9JK25 Clip1 rat S311 4769833 ASLKRsPsAssLSSM X +Prkaca PKACA P05132 mouse PTRF 19285 O54724 Cavin1 mouse S169 460680 VkLPAkLsVsksLkE PTRF_SDPR X +Prkaca PKACA P05132 mouse HSL 3991 Q05469 LIPE human S950 450194 EGFHPRRssQGAtQM Abhydrolase_3 X +Prkaca PKACA P05132 mouse Merlin 18016 P46662 Nf2 mouse S10 1720901 GAIASRMsFSsLKRK X X +Prkaca PKACA P05132 mouse BAD 12015 Q61337 Bad mouse S136 447862 PFRGRsRsAPPNLWA Bcl-2_BAD X X 9295; 5286; 4366 +Prkaca PKACA P05132 mouse PHLPP2 244650 Q8BXA7 Phlpp2 mouse S1207 4754865 FGIRRQNsVNsGILL X +Prkaca PKACA P05132 mouse NMDAR2B 14812 Q01097 Grin2b mouse S1303 450171 NKLRRQHsyDtFVDL NMDAR2_C X 20274; 71335 +Prkaca PKACA P05132 mouse PIP5K1B 18719 P70181 Pip5k1b mouse S214 455789 STYKRRAsRKEREKP PIP5K X X +Prkaca PKACA P05132 mouse DARPP-32 360616 Q6J4I0 Ppp1r1b rat T34 448047 MIRRRRPtPALLFRV DARPP-32 X 12438 +Prkaca PKACA P05132 mouse Stargazin 12300 O88602 Cacng2 mouse T321 451273 NTANRRTtPV_____ X +Prkaca PKACA P05132 mouse SLC29A1 63959 Q9JIM1 Slc29a1 mouse T276 21326705 PGPNsPPtNRNQsIK Nucleoside_tran X +Prkaca PKACA P05132 mouse GLUL 14645 P15105 Glul mouse T301 15501403 LDNARRLtGFHETSN X X +Prkaca PKACA P05132 mouse SIK 59329 Q9R1U5 Sik1 rat S577 465992 FQEGRRAsDTSLTQG X +Prkaca PKACA P05132 mouse perilipin 1 25629 P43884 Plin1 rat S223 450080 PSLLRRVstLANTLS Perilipin X +Prkaca PKACA P05132 mouse SLC23A2 54338 Q9EPR4 Slc23a2 mouse S403 483979 YYACARLsCAPPPPI Xan_ur_permease X X +Prkaca PKACA P05132 mouse MYBPC3 17868 O70468 Mybpc3 mouse S273 471079 RsAFRRtsLAGAGRR X +Prkaca PKACA P05132 mouse HSP20 126393 O14558 HSPB6 human S16 450706 PSWLRRAsAPLPGLS Crystallin X 36519 +Prkaca PKACA P05132 mouse GJD2 14617 O54851 Gjd2 mouse S110 471386 KQRERRYsTVFLALD Connexin X +Prkaca PKACA P05132 mouse DUSP9 75590 Q7TNL7 Dusp9 mouse S58 22694400 LRRLRRGsMSVRSLL Rhodanese X X +Prkaca PKACA P05132 mouse CACNA1C iso5 12288 Q0PCR6 Cacna1c mouse S1700 4714250 PEIRRAIsGDLtAEE CAC1F_C X +Prkaca PKACA P05132 mouse IRE1 78943 Q9EQY0 Ern1 mouse S724 7161100 KLAVGRHsFSRRsGV Pkinase X +NUAK1 NuaK1 O60285 human p21Cip1 1026 P38936 CDKN1A human S146 447836 GRkRRQtsMTDFyHs X +NUAK1 NuaK1 O60285 human MYPT1 4659 O14974 PPP1R12A human S472 452042 AGVTRsAssPRLsss X X +NUAK1 NuaK1 O60285 human Tau iso8 4137 P10636-8 MAPT human S262 447930 NVKskIGstENLkHQ Tubulin-binding X X +NUAK1 NuaK1 O60285 human CASP6 839 P55212 CASP6 human S257 452136 TLVNRKVsQRRVDFc Peptidase_C14 X +NUAK1 NuaK1 O60285 human p53 7157 P04637 TP53 human S392 447535 FktEGPDsD______ X 9281 +NUAK1 NuaK1 O60285 human MYPT1 4659 O14974 PPP1R12A human S910 1983104 sLLGRsGsysyLEER X X +NUAK1 NuaK1 O60285 human p21Cip1 12575 P39689 Cdkn1a mouse S141 447836 GRKRRQtsLTDFYHS X +NUAK1 NuaK1 O60285 human LATS1 9113 O95835 LATS1 human S464 451855 NIPVRsNsFNNPLGN X X +NUAK1 NuaK1 O60285 human p21Cip1 12575 P39689 Cdkn1a mouse S78 14577356 GLPKVyLsPGSRSRD X +NUAK1 NuaK1 O60285 human Tau iso8 4137 P10636-8 MAPT human S356 449104 rVQskIGsLDNItHV Tubulin-binding X X +NUAK1 NuaK1 O60285 human MYPT1 4659 O14974 PPP1R12A human S445 452077 LGLRktGsyGALAEI X X +NUAK1 NuaK1 O60285 human p53 7157 P04637 TP53 human S15 447490 PsVEPPLsQEtFsDL P53_TAD X 4030; 9235; 9284; 9286; 8695; 8514; 82530; 56979 +Mark2 MARK2 Q05512 mouse CAMSAP1 227634 A2AHC3 Camsap1 mouse S1464 1869962002 PIIHNAIsHCCLAGK CAMSAP_CKK X +Mark2 MARK2 Q05512 mouse KIFAP3 16579 P70188 Kifap3 mouse S60 4711034 QKIIRLKsLNANtDI KAP X +ULK2 ULK2 Q8IYT8 human STX17 55014 P56962 STX17 human S289 4774791 MMEKLtSsCPDLPSQ X +ULK2 ULK2 Q8IYT8 human STING 340061 Q86WV6 STING1 human S366 31064700 QEPELLIsGMEkPLP X 30495; 39887; 85735; 50907; 19781; 41622; 43499; 40818; 99309; 72650 +ULK2 ULK2 Q8IYT8 human beclin 1 8678 Q14457 BECN1 human S30 7446159 QPLkLDTsFkILDRV X 54101; 35955 +ULK2 ULK2 Q8IYT8 human Raptor 57521 Q8N122 RPTOR human S792 2314600 DKMRRAssYSsLNSL X 2083; 89146 +ULK2 ULK2 Q8IYT8 human DENND3 22898 A2RUS2 DENND3 human S490 23050193 ELAPRNSsLRLtDTA X +ULK2 ULK2 Q8IYT8 human Raptor 57521 Q8N122 RPTOR human S855 3205935 QRVLDtssLtQsAPA X +ULK2 ULK2 Q8IYT8 human Raptor 57521 Q8N122 RPTOR human S859 2024885 DtssLtQsAPAsPtN X +ULK2 ULK2 Q8IYT8 human SEC16A 9919 O15027 SEC16A human S846 55578720 LAQPINFsVSLSNSH X +ULK2 ULK2 Q8IYT8 human PIK3C3 5289 Q8NEB9 PIK3C3 human S249 35483209 ESsPILTsFELVKVP X 13857 +ULK2 ULK2 Q8IYT8 human DENND3 22898 A2RUS2 DENND3 human S472 7997148 THRRMVVsMPNLQDI X diff --git a/omniflow_project/_data/Regulatory_sites b/omniflow_project/_data/Regulatory_sites new file mode 100644 index 0000000..20b3aff --- /dev/null +++ b/omniflow_project/_data/Regulatory_sites @@ -0,0 +1,20194 @@ +GENE PROTEIN PROT_TYPE ACC_ID GENE_ID HU_CHR_LOC ORGANISM MOD_RSD SITE_GRP_ID SITE_+/-7_AA DOMAIN ON_FUNCTION ON_PROCESS ON_PROT_INTERACT ON_OTHER_INTERACT PMIDs LT_LIT MS_LIT MS_CST NOTES +AQP2 AQP2 Channel, misc.; Membrane protein, integral; Membrane protein, multi-pass; Transporter; Transporter, aquaporin family P41181 359 12q13.12 human K270-ub 999601 QSLPRGTkA______ protein degradation; intracellular localization; phosphorylation 19357255; 21209006 6 0 0 LIP5 binding to AQP2 is independent of AQP2 ubiquitination; stimulates phosphorylation of S261 +Pdpk1 PDK1 EC 2.7.11.1; KINASE; Kinase, protein; Nuclear receptor co-regulator; Protein kinase, AGC; Protein kinase, Ser/Thr (non-receptor) O55173 81745 10q12 rat Y379-p 447695 DEDCYGNyDNLLSQF enzymatic activity, induced translation, altered; cell adhesion, altered 18559349 8 1 0 Induces fibronectin expression and deposition and increases AngII mesangial cell hypertrophy +CD200R1 CD200R Membrane protein, integral; Receptor, misc. Q8TD46 131450 3q13.2 human Y325-p 458379 TEKNNPLyDTTNKVK molecular association, regulation DOK2(INDUCES) 19786546 2 2 11 recruitment of RasGAP by Dok2 +Gsk3b GSK3B EC 2.7.11.1; EC 2.7.11.26; KINASE; Kinase, protein; Protein kinase, CMGC; Protein kinase, Ser/Thr (non-receptor) P18266 84027 11q21 rat S9-p 449111 SGRPRTTsFAESCKP protein stabilization; molecular association, regulation; intracellular localization; enzymatic activity, inhibited; activity, inhibited; phosphorylation cell cycle regulation; apoptosis, altered; cell motility, induced; signaling pathway regulation; transcription, altered; autophagy, induced; cell growth, induced; apoptosis, inhibited; cytoskeletal reorganization; cell growth, altered 14-3-3 beta(INDUCES) 11018058; 11094086; 11533051; 15073173; 17200689; 19801631; 20841359; 21702924; 21736902; 22039465; 22046442; 22228770; 33518533; 33575839; 33864097; 34577062; 35216064; 8816781 570 46 227 +Sik2 QIK EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, CAMK; Protein kinase, Ser/Thr (non-receptor) Q3LRT3 315649 8q23 rat T484-p 478056 RSGQRRHtLSEVTNQ protein degradation 21220102 3 10 85 +PTEN PTEN Carbohydrate Metabolism - inositol phosphate; EC 3.1.3.16; EC 3.1.3.48; EC 3.1.3.67; Motility/polarity/chemotaxis; Nuclear receptor co-regulator; PHOSPHATASE; Phosphatase, lipid; Tumor suppressor P60484 5728 10q23.31 human S380-p 448313 EPDHYRYsDTTDSDP molecular association, regulation; protein stabilization; intracellular localization; enzymatic activity, inhibited; protein conformation; phosphorylation; enzymatic activity, altered cell cycle regulation; carcinogenesis, induced; signaling pathway regulation; transcription, altered; neural plasticity; cell differentiation, altered; chromatin organization, altered; cell motility, altered; apoptosis, inhibited PTEN(INDUCES); PTEN(DISRUPTS) DNA(INDUCES) 10866658; 11035045; 12077256; 17240336; 17565999; 22413754; 24706748; 24766807; 25823029; 33760042; 35884549; 36155262 40 0 0 regulates CHK1 phosphorylation and activation and H2AX phosphorylation +Psma2 PSMA2 EC 3.4.25.1; Protease; Proteasome complex P17220 29669 17q12.1 rat Y121-p 450235 VASVMQEyTQSGGVR Proteasome intracellular localization 8794741 1 0 0 +DDX5 DDX5 EC 3.6.4.13; Helicase; Nuclear receptor co-regulator; Nucleolus; RNA splicing; RNA-binding; Spliceosome P17844 1655 17q23.3 human T69-p 1875793000 HPDLARRtAQEVETY sumoylation; protein stabilization; molecular association, regulation; ubiquitination carcinogenesis, induced; cell motility, induced; cell growth, induced PIAS1(INDUCES); DROSHA(INDUCES); DGCR8(INDUCES) 34936874 1 0 0 inhibits ubiquitination +MAPT Tau iso8 ACETYLTRANSFERASE; Acetyltransferase; Cytoskeletal P10636-8 4137 17q21.31 human T231-p 449079 KKVAVVRtPPKSPSS molecular association, regulation; protein processing; intracellular localization; protein conformation; phosphorylation apoptosis, altered; cell growth, inhibited; autophagy, inhibited; cytoskeletal reorganization; signaling pathway regulation TUBA4A(DISRUPTS); Fyn(DISRUPTS); Tau iso8(INDUCES); TUBA1A(INDUCES); PIN1(INDUCES); BIN1(DISRUPTS) 12414518; 15190058; 15542598; 16024016; 16115884; 16687396; 17045592; 20375017; 20550628; 20663882; 21731772; 25573097; 29298849; 31065832; 33710538; 33967735 149 48 14 +DICER1 DICER1 Cell development/differentiation; EC 3.1.26.3; Helicase; RNA processing; RNA-binding; Ribonuclease Q9UPY3 23405 14q32.13 human S1016-p 3216312 GKALPLSsAEKRKAK PAZ intracellular localization carcinogenesis, induced; DNA repair, induced; cell growth, induced; RNA stability, altered 28642363; 35995401 2 8 0 +DNMT1 DNMT1 Amino Acid Metabolism - cysteine and methionine; Cell development/differentiation; EC 2.1.1.37; METHYLTRANSFERASE; Methyltransferase; Methyltransferase, DNA; Transcription regulation P26358 1786 19p13.2 human K961-ac 25171006 SPVKRPRkEPVDEDL BAH cell cycle regulation 21947282 1 1 0 +BUB3 BUB3 Cell cycle regulation O43684 9184 10q26.13 human S19-p 15180600 PPEDGISsVKFSPNT WD40 apoptosis, induced 20057499 1 1 0 caspase-independent mitotic death (CIMD) +EIF2S1 eIF2-alpha RNA-binding; Translation; Translation initiation P05198 1965 14q23.3 human K141-ac 11324636 TAWVFDDkYKRPGYG EIF_2_alpha apoptosis, induced 27911441 1 5 0 +BUD13 BUD13 RNA splicing; Spliceosome Q9BRD0 84811 11q23.3 human T159-p 470734 PRRARHDtPDPSPLR molecular association, regulation carcinogenesis, induced; cell growth, induced FBXW7(DISRUPTS) 37382881 1 56 44 +MRE11 MRE11A Cell cycle regulation; DNA repair, damage; DNA-binding; Deoxyribonuclease P49959 4361 11q21 human S382-p 11506403 PFSVLRFsQKFVDRV Mre11_DNA_bind molecular association, regulation DNA(DISRUPTS) 19709933 1 0 0 +CLASP2 CLASP2 Cytoskeletal; Motility/polarity/chemotaxis O75122 23122 3p22.3 human S1092-p 27434506 MKLTQEEsFSVWDEH cell cycle regulation 23045552 1 1 0 +Syk Syk EC 2.7.10.2; KINASE; Kinase, protein; Protein kinase, TK; Protein kinase, tyrosine (non-receptor) P48025 20963 13 A5|13 27.41 cM mouse Y317-p 447658 STVSFNPyEPTGGPW molecular association, regulation; enzymatic activity, inhibited; protein conformation; phosphorylation endocytosis, altered; transcription, altered; signaling pathway regulation CBL(INDUCES); PIK3R1(INDUCES) 12077122; 15536084; 15576379; 9820500 21 30 1019 +E2F1 E2F1 DNA-binding; Transcription factor Q01094 1869 20q11.22 human K120-ac 459018 RHPGKGVkSPGEKSR protein stabilization; molecular association, regulation apoptosis, induced; transcription, induced DNA(INDUCES) 10675335; 10753885; 22184068 3 0 0 etoposide-induced DNA damage, pRB-free form of E2F1, does not bind to pRB; both complexes act in parallel to induce transcription of proapoptotic genes +BRIP1 BRIP1 EC 3.6.4.13; Helicase; Oncoprotein Q9BX63 83990 17q23.2 human K1249-ac 15293613 KGMFPGFk_______ DNA repair, induced 22792074 1 1 1 FANCJ K1249R or BRIP1 K1249Q promotes pol H- or Rad54-dependent repair, respectively; promotes resection-associated events; promote an RPA response +FOXO4 FOXO4 DNA-binding; Oncoprotein; Transcription factor P98177 4303 Xq13.1 human S268-p 231166708 SSNASSVsTRLSPLR protein degradation; phosphorylation 28945225 1 0 0 26 S proteasome-mediated FOXO4 proteolysis in the nuclei of RAS mutant colon cancer cells +Cabp4 CABP4 Calcium-binding Q8VHC5 73660 19|19 A mouse S37-p 1315600 PALTRRRsKKESWHP activity, induced; molecular association, regulation CACNA1F(INDUCES) 18003854; 23341017 2 1 0 Ca2+ v1.3 channel activity induced; Ca(2+) current kinetics +NCOA3 SRC-3 ACETYLTRANSFERASE; Acetyltransferase; EC 2.3.1.48; Motility/polarity/chemotaxis; Nuclear receptor co-regulator; Transcription, coactivator/corepressor Q9Y6Q9 8202 20q13.12 human S857-p 453084 PPYNRAVsLDSPVSV molecular association, regulation carcinogenesis, induced; cell growth, induced; cell motility, induced; transcription, induced ER-alpha(DISRUPTS); ETV4(INDUCES) 15383283; 22505454; 23850489; 33542078; 36476868 11 48 5 +GNA11 G-alpha 11 G protein; G protein, heterotrimeric; G protein, heterotrimeric alpha G(q) P29992 2767 19p13.3 human S154-p 471084 RRREYQLsDSAKYYL G-alpha molecular association, regulation; receptor desensitization, altered 5-HT(2A)(DISRUPTS) 17056873; 17646429 2 0 0 +Il1rl1 IL1RL1 Membrane protein, integral; Receptor, cytokine P14719 17082 1 B|1 19.19 cM mouse K326-ub 25585003 HTIRLRRkQPIDHRS protein degradation apoptosis, inhibited 22660580 1 0 0 +POLE POLE DNA repair, damage; DNA replication; EC 2.7.7.7; Nucleotide Metabolism - purine; Nucleotide Metabolism - pyrimidine; Transferase Q07864 5426 12q24.33 human S1940-p 481837 IHCGLQDsQKAGGAE molecular association, regulation MMS19(INDUCES) 27235625 1 8 24 +CDC25C CDC25C EC 3.1.3.48; Motility/polarity/chemotaxis; PHOSPHATASE; Protein phosphatase, dual-specificity P30307 995 5q31.2 human S75-p 125104500 PKRCLDLsNLSSGEI cell cycle regulation 28591578 1 1 0 +ECE1 ECE1 iso3 Cell surface; EC 3.4.24.71; Membrane protein, integral; Protease; Vesicle P42892-3 1889 1p36.12 human S20-p 3053606 EDLVDSLsEGDAYPN protein stabilization; intracellular localization; phosphorylation cell cycle regulation; carcinogenesis, induced; cell growth, induced; cell motility, induced; apoptosis, inhibited; transcription, induced 26543229; 32850305 3 11 0 induces FAK phosphorylation; colon cancer cell invasion. +DCX Doublecortin Cytoskeletal; Motility/polarity/chemotaxis O43602 1641 Xq23 human S297-p 451111 PQKTSAKsPGPMRRS molecular association, regulation cytoskeletal reorganization TUBA1B(DISRUPTS); ACTA1(INDUCES) 15632197 8 1 4 +CD5 CD5 Cell surface; Membrane protein, integral P06127 921 11q12.2 human Y453-p 447774 ASHVDNEySQPPRNS activity, induced 11751967 6 10 292 phosphorylation of Y453 is essential for CD5 functions, including inhibition of the BCR-induced calcium response, inhibition of Akt translocation, inhibition of IL-2 production. +CHRM2 mAChR M2 GPCR, family 1; Membrane protein, integral; Membrane protein, multi-pass; Receptor, GPCR P08172 1129 7q33 human T423-p 487430 CIPNTVWtIGYWLCY 7tm_1 molecular association, regulation 17525129 1 0 0 +MFN2 MFN2 Cell cycle regulation; Cytoskeletal; EC 3.6.5.-; Hydrolase; Membrane protein, integral; Membrane protein, multi-pass; Mitochondrial O95140 9927 1p36.22 human S27-p 25594503 HMAEVNAsPLKHFVT protein degradation; ubiquitination apoptosis, induced HUWE1(INDUCES) 22748923 2 3 0 HUWE1 associates with Mfn2, and leads to Its ubiquitination and degradation. +PACS2 PACS2 Q86VP3 23241 14q32.33 human S207-p 1884003500 EEEYESFsSEQEASD intracellular localization 37523531 1 0 0 +KCNMA1 KCNMA1 Channel, potassium; Endoplasmic reticulum; Membrane protein, integral; Membrane protein, multi-pass Q12791 3778 10q22.3 human S992-p 469989 HGMLRQPsITTGVNI activity, induced 11078709 4 2 0 +Hcn1 HCN1 Membrane protein, integral; Membrane protein, multi-pass Q9JKB0 rat S791-p 1872043505 PKNEVHKsTQALHNT activity, inhibited 33571596 1 1 0 +Pycard PYCARD Adaptor/scaffold; Tumor suppressor Q9EPB4 66824 7|7 F3 mouse K55-ub 1881518205 DAIDLTDkLVSYYLE molecular association, regulation NLRP3(INDUCES); PYCARD(INDUCES) 34706239 1 0 0 PYCARD oigomerization, NLRP3 infammasome activation +CCNA2 CCNA2 Cell cycle regulation; Nuclear receptor co-regulator P20248 890 4q27 human K68-ac 7761213 LAQQQRPkTRRVAPL Cyclin_N2 protein degradation; molecular association, regulation cell cycle regulation CDK2(DISRUPTS) 19483727; 23760262 2 1 0 +ACTL6A BAF53A O96019 86 3q26.33 human S233-p 471130 KEAVREGsPANWKRK Actin molecular association, regulation apoptosis, induced; transcription, induced RASSF6(INDUCES) 34898277 1 37 10 +HDAC3 HDAC3 Apoptosis; Cell cycle regulation; DEACETYLASE; Deacetylase; EC 3.5.1.98; Nuclear receptor co-regulator; Transcription, coactivator/corepressor O15379 8841 5q31.3 human Y331-p 15228119 PYSEYFEyFAPDFTL activity, induced; intracellular localization; enzymatic activity, induced carcinogenesis, induced; cell growth, induced 30317579; 31430896 2 0 1 +CROCC CROCC iso2 Cytoskeletal Q5TZA2-2 9696 1p36.13 human S922-p 481961 TESELRAsQEKISKM protein stabilization; phosphorylation carcinogenesis, inhibited; cell growth, inhibited; transcription, induced 24240686 1 3 0 p38 phosphorylation; suppress ubiquitination/protein degradation +TBX21 TBX21 DNA-binding; Transcription factor Q9UL17 30009 17q21.32 human Y305-p 20583305 QFIAVTAyQNAEITQ T-box molecular association, regulation cell differentiation, altered; cell growth, induced; transcription, induced DNA(INDUCES) 21690296 1 0 0 +Ryr2 RYR2 Channel, ligand-gated; Membrane protein, integral; Membrane protein, multi-pass; Transporter; Transporter, ion channel E9Q401 20191 13 A1|13 4.38 cM mouse S2030-p 455603 TIRGRLLsLVEKVTY activity, induced; protein conformation; phosphorylation 17693412; 17967164; 30541771 14 4 1 inhibits phosphorylation at S2807 and S2813, increases calcium sensitivity +Rit1 RIT1 G protein; G protein, monomeric; G protein, monomeric, Ras P70426 19769 3|3 F1 mouse K135-ub 12382090 PVVLVGNkSDLKQLR Ras protein degradation; ubiquitination 30872527 1 3 2 ubiquitination occured only when TUBEs and LZTR1 were coexpressed, when RIT1 oncogenic mutations are present ubiquitination was decreased +ADD2 ADD2 Cytoskeletal; Motility/polarity/chemotaxis P35612 119 2p13.3 human S697-p 467408 GPMSPEGsPSKSPSK cell growth, induced; cytoskeletal reorganization 21606488 1 13 0 +LEPR LEPR Membrane protein, integral; Receptor, cytokine P48357 3953 1p31.3 human K879-ub 1872271904 WEDVPNPkNCSWAQG receptor internalization, induced endocytosis, induced 16482222 1 0 0 +MAD1L1 MAD1L1 Cell cycle regulation; Cytoskeletal Q9Y6D9 8379 7p22.3 human T680-p 5024706 SKMQLLEtEFSHTVG MAD activity, induced; intracellular localization cell cycle regulation 18922800 1 1 0 +TRPV1 TRPV1 Channel, cation; Membrane protein, integral; Membrane protein, multi-pass; Receptor, misc. Q8NER1 7442 17p13.2 human Y200-p 458384 ASYTDSYyKGQTALH Ank_2 receptor desensitization, altered; intracellular localization 16319926 2 0 0 +ATG13 ATG13 Autophagy; Vesicle O75143 9776 11p11.2 human T342-p 1869357206 DRTHCAAtPSSSEDT cell cycle regulation; autophagy, induced; cell growth, induced 32516310 1 1 0 +Map3k8 Cot EC 2.7.11.25; KINASE; Kinase, protein; Oncoprotein; Protein kinase, STE; Protein kinase, Ser/Thr (non-receptor) Q07174 26410 18 A1|18 2.73 cM mouse S400-p 447712 EDQPRCQsLDSALFE activity, induced; molecular association, regulation; phosphorylation signaling pathway regulation ERK2(INDUCES); 14-3-3 gamma(INDUCES) 17709378; 24912162 4 2 0 induces Cot signaling +Cd22 CD22 Cell surface; Membrane protein, integral P35329 12483 7 B1|7 19.26 cM mouse Y863-p 450944 QAKEDVDyVTLKH__ molecular association, regulation; activity, inhibited; phosphorylation Syk(INDUCES); PLCG1(INDUCES); SHP-1(INDUCES); PIK3R1(INDUCES) 10373493; 11551923; 18024433; 27276708 6 0 12 negatively regulate calcium signal +ITPR1 IP3R1 Channel, calcium; Channel, ligand-gated; Membrane protein, integral; Membrane protein, multi-pass Q14643 3708 3p26.1 human T800-p 450269 RDPQEQVtPVKYARL molecular association, regulation exocytosis, induced Other(INDUCES) 16237118 4 0 0 enhances IP3 binding to IP3R1, and calcium release +Pdgfrb PDGFRB EC 2.7.10.1; KINASE; Kinase, protein; Membrane protein, integral; Oncoprotein; Protein kinase, TK; Protein kinase, tyrosine (receptor) P05622 18596 18 E1|18 34.41 cM mouse Y580-p 447519 SDGHEYIyVDPVQLP molecular association, regulation PLCG1(INDUCES) 11281646 6 1 0 +Bckdha BCKDH E1-alpha Amino Acid Metabolism - valine, leucine and isoleucine degradation; EC 1.2.4.4; Lyase; Mitochondrial; Oxidoreductase P11960 25244 1q21 rat S333-p 449636 TYRIGHHsTSDDSSA E1_dh enzymatic activity, inhibited cell growth, induced 27472223; 3947057 10 60 24 inhibited catabolism of the branched-chain amino acids, decrease phosphorylation frogleg phenotype +Cdh1 CDH1 Cell adhesion; Membrane protein, integral; Motility/polarity/chemotaxis; UBIQUITIN LIGASE; Ubiquitin ligase P09803 12550 8 D3|8 53.18 cM mouse S840-p 465565 LVFDYEGsGSEAASL CADH_Y-type_LIR molecular association, regulation CTNNB1(INDUCES) 11348595 5 1 0 +VCP VCP Chaperone; DNA repair, damage; EC 3.6.4.6; Endoplasmic reticulum; Hydrolase P55072 7415 9p13.3 human T76-p 1876872800 CIVLSDDtCSDEKIR CDC48_N intracellular localization; protein conformation cell cycle regulation; carcinogenesis, induced; apoptosis, inhibited; cytoskeletal reorganization; transcription, altered 35430615 1 0 0 +MDC1 MDC1 Cell cycle regulation Q14676 9656 6p21.33 human S20-p 63083900 EEEETEQsSESLRCN intracellular localization cell cycle regulation 28193847 1 0 0 maintenance of chrosome stabiliy +SLC6A3 DAT Membrane protein, integral; Membrane protein, multi-pass; Transporter; Transporter, SLC family Q01959 6531 5p15.33 human T613-p 451142 RGEVRQFtLRHWLKV signaling pathway regulation 22514303 2 0 0 +H2ac4 H2A.1 DNA-binding C0HKE1 319172 13|13 A3.1 mouse K118-ub 3945247 IQAVLLPkKTESHHK Histone_H2A_C molecular association, regulation; ubiquitination cell cycle regulation; cell growth, induced; transcription, altered; transcription, inhibited FBXL10(INDUCES) DNA(INDUCES) 23256043; 23395003; 24025767; 24070375 12 14 157 +HIF1A HIF1A Autophagy; DNA-binding; Transcription factor Q16665 3091 14q23.2 human K10-ac 25126718 GAGGANDkKKISSER protein degradation transcription, inhibited 21917920; 28319066 2 0 0 +H3C1 H3 DNA-binding P68431 8350 6p22.2 human K27-m2 1308912 LATKAARkSAPATGG Histone carcinogenesis, induced; cell differentiation, induced; chromatin organization, altered; transcription, induced; transcription, inhibited 18628788; 20132554; 20864036; 31015297 42 21 7 +IL2RB IL2RB Membrane protein, integral; Receptor, cytokine P14784 3560 22q12.3 human Y418-p 450884 LSGEDDAyCTFPSRD molecular association, regulation apoptosis, inhibited; cell growth, altered SHB(INDUCES) 12200137 3 0 0 +IRF3 IRF3 DNA-binding; Transcription factor Q14653 3661 19q13.33 human T135-p 477901 GGGSTSDtQEDILDE protein stabilization; intracellular localization 11867762 2 24 7 +EEF2 EEF2 Translation; Translation elongation P13639 1938 19p13.3 human K594-m1 58123400 SNVLCLSkSPNKHNR molecular association, regulation L3MBTL iso4(INDUCES) 23583077 0 1 0 +YAP1 YAP1 Oncoprotein; Transcription, coactivator/corepressor P46937 10413 11q22.1 human S367-p 471290 GTQNPVSsPGMSQEL molecular association, regulation; intracellular localization cell cycle regulation; carcinogenesis, induced; cell motility, induced; apoptosis, inhibited; cytoskeletal reorganization TEAD4(DISRUPTS) 24101154; 24812269; 26933062 8 29 12 mitotic shift, important for proper mitosis and cytokinesis +PHB1 PHB Apoptosis; Cell cycle regulation; Chaperone; Mitochondrial; Motility/polarity/chemotaxis; Nuclear receptor co-regulator; Oncoprotein; Transcription, coactivator/corepressor P35232 5245 17q21.33 human T258-p 11139253 LSRSRNItYLPAGQS protein stabilization; molecular association, regulation; intracellular localization; phosphorylation carcinogenesis, induced; cell growth, induced; cell motility, induced; apoptosis, inhibited; transcription, inhibited; signaling pathway regulation ER-alpha(DISRUPTS); RAF1(INDUCES) DNA(DISRUPTS) 22410782; 25575814; 25719244; 32665357 6 0 1 induces ERK phosphorylation and modulates Ras phosphorylation; dephosphorylation induces binding to Axin1 promoter thus inhibiting Wnt/beta-catenin signaling through degradation of beta-catenin; PIP3 induced migration/invasion, colonization/ metastasis ; mitochondrial localization +NCOA3 SRC-3 ACETYLTRANSFERASE; Acetyltransferase; EC 2.3.1.48; Motility/polarity/chemotaxis; Nuclear receptor co-regulator; Transcription, coactivator/corepressor Q9Y6Q9 8202 20q13.12 human S102-p 4661900 VQKADVSsTGQGVID protein degradation; molecular association, regulation carcinogenesis, inhibited; cell growth, altered SPOP(INDUCES) 18922467; 21577200 2 0 0 +ATM ATM DNA repair, damage; EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, Ser/Thr (non-receptor); Protein kinase, atypical; Tumor suppressor Q13315 472 11q22.3 human T373-p 481860 ISQSYTTtQRESSDY enzymatic activity, inhibited; protein conformation cell cycle regulation; apoptosis, inhibited 27939942 1 1 0 +EGFR EGFR EC 2.7.10.1; KINASE; Kinase, protein; Membrane protein, integral; Oncoprotein; Protein kinase, TK; Protein kinase, tyrosine (receptor) P00533 1956 7p11.2 human K860-ub 1065315 ITDFGLAkLLGAEEK PK_Tyr_Ser-Thr protein degradation 17940017 1 6 1 +Polr2a POLR2A EC 2.7.7.48; EC 2.7.7.6; Nucleotide Metabolism - purine; Nucleotide Metabolism - pyrimidine; Transcription initiation complex; Transferase P08775 20020 11 B3|11 42.86 cM mouse S1616-p 450204 TPQSPSYsPTSPSYS RNA_pol_Rpb1_R molecular association, regulation; intracellular localization; enzymatic activity, inhibited; phosphorylation; enzymatic activity, induced RNA splicing, induced; transcription, induced; transcription, altered SETD1B(INDUCES); SETD2(INDUCES); U2AF2(INDUCES); SETD1A(INDUCES) 17535807; 21385826; 21639898; 27322654; 28423325; 28768201 81 4 0 recruitment of CDK9 to the Cxcl1 locus, repressed by Hes1 ; elongation, splicing optimization correlates with increasing S1616 phosphorylatio; deletion of MNAT reduces S1619 phosphorylation and defective capping and reduced S1616 phosphorylation and defect in Pol II transcription +Nr4a1 Nur77 Apoptosis; DNA-binding; Nuclear receptor P22829 79240 7q36 rat S350-p 447942 GRRGRLPsKPKQPPD molecular association, regulation apoptosis, inhibited 14-3-3 beta(INDUCES) DNA(INDUCES) 11438550; 16835233 11 4 0 +Aicda AID EC 3.5.4.38; Hydrolase Q9WVE0 11628 6|6 F1 mouse T27-p 471423 WAKGRHEtYLCYVVK APOBEC2 molecular association, regulation; enzymatic activity, induced chromatin organization, altered RPA1(INDUCES) 16251902; 17911613 5 2 0 promotes deamination of transcribed dsDNA substrates in B cells; Mutation of either site significantly decreases gene conversion (GCV) & somatic hypermutation (SHM) frequency. +PLCG1 PLCG1 Carbohydrate Metabolism - inositol phosphate; EC 3.1.4.11; Motility/polarity/chemotaxis; Phospholipase P19174 5335 20q12 human Y1253-p 448576 EGSFESRyQQPFEDF intracellular localization 22847294 12 19 85 nuclear localization +DVL2 DVL2 Adaptor/scaffold; Motility/polarity/chemotaxis O14641 1856 17p13.1 human Y18-p 12170303 VGETKVIyHLDEEET DIX transcription, induced 19920076 1 1 0 regulates Wnt3a/beta-catenin signaling +Agtr1a AT1 GPCR, family 1; Membrane protein, integral; Membrane protein, multi-pass; Receptor, GPCR P29754 11607 13 A3.2|13 13.19 cM mouse Y319-p 448745 YFLQLLKyIPPKAKS activity, induced 16902180 5 0 0 Transgenic mice with cardiac-specific overexpression of Y319F mutant AT1 have reduced EGFR activation, and do not develop cardiac hypertrophy, fibrosis or apoptosis +Lpp LPP Adaptor/scaffold; Cytoskeletal; Motility/polarity/chemotaxis Q8BFW7 210126 16|16 B1 mouse Y318-p 448947 RSEGDTAyGQQVQPN cell cycle regulation; cell motility, altered 18515860 1 16 256 +WDR62 WDR62 Adaptor/scaffold O43379 284403 19q13.12 human T1053-p 460021 PSSSLPQtPEQEKFL activity, induced; protein degradation; molecular association, regulation; ubiquitination; intracellular localization; protein conformation cell cycle regulation; cytoskeletal reorganization FBXW7(INDUCES) 25501809; 30566428; 34137789 3 10 21 +FOXO1 FOXO1A DNA-binding; Nuclear receptor co-regulator; Oncoprotein; Transcription factor Q12778 2308 13q14.11 human S212-p 4258803 SSAGWKNsIRHNLSL Forkhead molecular association, regulation DNA(DISRUPTS) 18786403 3 1 0 +TCF3 E2A Cell development/differentiation; DNA-binding; Oncoprotein; Transcription factor P15923 6929 19p13.3 human S379-p 3180968 AGAPGALsPSYDGGL activity, inhibited transcription, inhibited 19801649 1 35 15 +Acin1 acinus Apoptosis; RNA splicing; RNA-binding; Spliceosome E9PST5 305884 15p13 rat S1180-p 456759 GPRSRSRsRDRRRKE RSB_motif protein stabilization 16177823 4 2 0 S1180 phosphorylation prevents proteolytic degradation of acinus and blocks chromatin condensation in vivo and in vitro +DEPTOR DEPTOR Apoptosis Q8TB45 64798 8q24.12 human S244-p 4723808 SSQETHDsPFCLRKQ protein degradation; molecular association, regulation carcinogenesis, induced; apoptosis, inhibited; signaling pathway regulation mTOR(DISRUPTS) 19446321 2 17 9 PI3K-Akt signaling +REST REST C2H2-type zinc finger protein; Cell development/differentiation; DNA-binding; Transcription factor Q13127 5978 4q12 human S861-p 36320700 SVSTEDLsPPSPPLP protein degradation; molecular association, regulation; protein conformation cell differentiation, inhibited; transcription, induced BTRC(INDUCES); RCOR1(DISRUPTS); PIN1(INDUCES) 25197063; 30217818 2 2 0 +Sik2 QIK EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, CAMK; Protein kinase, Ser/Thr (non-receptor) Q8CFH6 235344 9|9 A5.3 mouse S358-p 487501 DGRQRRPsTIAEQTV enzymatic activity, induced 17805301 5 9 134 +SP1 SP1 C2H2-type zinc finger protein; DNA-binding; Transcription factor P08047 6667 12q13.13 human S612-gl 5262505 TCPYCKDsEGRGSGD transcription, induced 18513490 2 1 0 +Ripk1 RIPK1 EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, Ser/Thr (non-receptor); Protein kinase, TKL Q60855 19766 13 A3.3|13 14.01 cM mouse S25-p 27116402 LEKTDLDsGGFGKVS PK_Tyr_Ser-Thr enzymatic activity, inhibited; phosphorylation 36707047 3 4 0 inhibits phosphorylation of itself at S166 +TRADD TRADD Adaptor/scaffold; Apoptosis Q15628 8717 16q22.1 human S296-p 20831308 LEENELTsLAEDLLG Death molecular association, regulation transcription, induced FADD(INDUCES); TNF-R1(INDUCES); RIP(INDUCES) 21724995 1 0 0 +ELF4 ELF4 DNA-binding; Oncoprotein; Transcription factor Q99607 2000 Xq26.1 human T643-p 463813 SLLTRSPtPAPFSPF protein degradation 16581786; 25081543 2 6 2 +Blnk BLNK Adaptor/scaffold Q9QUN3 17060 19 C3|19 34.26 cM mouse K42-ub 23303202 KIKKLKVkGPPSVPR molecular association, regulation; ubiquitination 14-3-3 beta(INDUCES) 22334673 1 0 0 Thr-152 phosphorylation induces BLNK ubiquitination at K37, K38, K42. +Nfatc2 NFAT1 DNA-binding; Transcription factor Q60591 18019 2 H3|2 88.91 cM mouse K897-sm 12057402 LPTGVTVkQEQNLDQ intracellular localization transcription, induced 15117942 1 1 0 +APOBEC3G APOBEC3G EC 3.5.4.-; Hydrolase; RNA processing; RNA-binding Q9HC16 60489 22q13.1 human K297-ub 11956702 SCAQEMAkFISKNKH NAD2 protein degradation 19887642 1 0 0 +RAPH1 RAPH1 Adaptor/scaffold; Motility/polarity/chemotaxis Q70E73 65059 2q33.2 human Y426-p 465028 LLRASGIyYVPKGKA PH molecular association, regulation cell motility, induced 26996666 2 1 14 Lpd-Scar/WAVE interaction is positively regulated by c-Abl and c-Src, breast cancer cell invasion +CYCS CYCS Apoptosis; Mitochondrial; Oxidoreductase; PHOSPHATASE; Protein phosphatase, Ser/Thr (non-receptor) P00004 100053958 horse K73-ac 479678 MEYLENPkKYIPGTK Cytochrom_C enzymatic activity, induced 19645667 1 5 83 +NKAP NKAP Unknown function Q8N5F7 79576 Xq24 human Y352-p 34731681 ASFECSGyVMSGSRH Nkap_C molecular association, regulation apoptosis, inhibited HDAC3(INDUCES) 30804042 1 0 2 regulates hematopoietic stem cell maintenance and survival +TTK TTK Cancer Testis Antigen (CTA); EC 2.7.12.1; KINASE; Kinase, protein; Protein kinase, Other; Protein kinase, dual-specificity (non-receptor) P33981 7272 6q14.1 human T46-p 41389704 NKISADTtDNSGTVN intracellular localization; enzymatic activity, induced 26119734; 36395767 2 1 0 +KIF18A KIF18A Microtubule-binding; Motor Q8NI77 81930 11p14.1 human S684-p 3207072 KGQHTLKsPPSQSVQ molecular association, regulation; enzymatic activity, inhibited cell cycle regulation PPP2R2C(DISRUPTS); PPP2R3B(INDUCES); PPP2R5C(DISRUPTS); PPP2R3A(INDUCES) 32900880 0 8 0 +Pard3 PAR3-alpha Adaptor/scaffold; Motility/polarity/chemotaxis Q9Z340 81918 19q12 rat S852-p 1983958 VKTRKSKsMDLGIAD intracellular localization cytoskeletal reorganization 33093242 1 42 0 regulation of PAR3 oligomerization, regulation of tight junction formations and morphological changes in epithelial cell layer +Cacng2 Stargazin Channel, calcium; Membrane protein, integral; Membrane protein, multi-pass Q71RJ2 84347 7q34 rat S237-p 455314 RYRYQRRsRSSSRST molecular association, regulation neural plasticity PSD-95(INDUCES) 25843401 3 0 0 +PDE6G PDE6G EC 3.1.4.35; Nucleotide Metabolism - purine; Phosphodiesterase P04972 281977 cow T22-p 449334 RVMGGPVtPRKGPPK PDE6_gamma phosphorylation 19878658 5 1 5 mutation of this site attenuates basal PDE6G phosphorylation at T35 +NCAM1 NCAM1 iso1 Cell adhesion; Membrane protein, GPI anchor; Membrane protein, integral; Motility/polarity/chemotaxis P13591-1 4684 11q23.2 human S774-p 456432 AAFSKDEsKEPIVEV phosphorylation cell growth, induced 22419107 2 32 2 CREB phosphorylation and activation +RELA NFkB-p65 DNA-binding; Nuclear receptor co-regulator; Transcription factor Q04206 5970 11q13.1 human K315-m1 7493901 TFKSIMKkSPFSGPT protein degradation transcription, inhibited 19262565 2 1 0 +JUN Jun Oncoprotein; Transcription factor P05412 3725 1p32.1 human S249-p 455367 LSPIDMEsQERIKAE molecular association, regulation; activity, inhibited carcinogenesis, induced; cell growth, induced; apoptosis, inhibited; transcription, altered SP1(DISRUPTS) 1516134; 17215518; 34936696 4 1 1 +SMN1 SMN RNA processing; RNA-binding Q16637 6606 5q13.2 human S18-p 12668173 GVPEQEDsVLFRRGT molecular association, regulation; intracellular localization coilin(INDUCES) 24602413 1 4 0 +Stx16 STX16 Membrane protein, integral; Vesicle Q8BVI5 228960 2|2 H4 mouse T7-p 4754210 _MATRRLtDAFLLLR molecular association, regulation; intracellular localization VPS45A(DISRUPTS) 37520260 1 2 12 regulates GLUT4 localization +NUMB NUMB iso3 Cell development/differentiation P49757-3 8650 14q24.2-q24.3 human S7-p 487518 _MNKLRQsFRRKKDV molecular association, regulation; intracellular localization endocytosis, inhibited AP2A1(DISRUPTS); CDH1(DISRUPTS); CTNND1(DISRUPTS) 21775625 2 3 1 +Mapt Tau ACETYLTRANSFERASE; Acetyltransferase; Cytoskeletal P10637 17762 11 67.79 cM|11 E1 mouse S701-p 449132 DTSPRHLsNVSSTGS molecular association, regulation AKAP5(INDUCES); PKAR2B(INDUCES); PKACB(INDUCES) 10460255 13 10 5 +Cux1 CUTL1 DNA-binding; Membrane protein, integral; Transcription factor P53564 13047 5 G2|5 75.96 cM mouse S1170-p 487431 PKPWHKLsLKGREPF CUT transcription, inhibited 17682059 1 0 0 inhibits FIH-1 expression +YBX3 CSDA RNA-binding; Transcription factor P16989 8531 12p13.2 human S134-p 3181076 NPRKYLRsVGDGETV CSD cell growth, induced 21368869 1 30 1 +SP1 SP1 C2H2-type zinc finger protein; DNA-binding; Transcription factor P08047 6667 12q13.13 human T737-p 36897200 AGSEGSGtATPSALI protein stabilization; molecular association, regulation; intracellular localization cell cycle regulation RNF4(DISRUPTS) DNA(DISRUPTS) 25398907 1 0 0 +Oprd1 DOR-1 GPCR, family 1; Membrane protein, integral; Membrane protein, multi-pass; Receptor, GPCR P32300 18386 4 D2.3|4 64.78 cM mouse S363-p 448550 RVTACTPsDGPGGGA receptor internalization, induced; receptor desensitization, induced; receptor desensitization, altered; intracellular localization; receptor internalization, altered 10973976; 19014372; 21220103 12 1 0 +CTTN Cortactin Actin-binding; Cytoskeletal; Motility/polarity/chemotaxis Q14247 2017 11q13.3 human K87-ac 466100 ASHGYGGkFGVEQDR HS1_rep molecular association, regulation; intracellular localization cell motility, inhibited ACTB(DISRUPTS) 17643370 1 4 13 Acetylation prevents localization to membrane ruf?es. +NRF1 NRF1 DNA-binding; Transcription factor Q16656 4899 7q32.2 human S102-p 1868914505 HVFESNPsIRKRQQT Nrf1_DNA-bind molecular association, regulation cell cycle regulation; transcription, altered DNA(DISRUPTS) 31350280 1 1 0 meiotic regulation +TOP1 TOP1 EC 5.99.1.2; Isomerase; Nucleolus; Oncoprotein P11387 7150 20q12 human K391-sm 40724402 INCSKDAkVPSPPPG Topoisom_I_N molecular association, regulation; enzymatic activity, inhibited POLR2A(INDUCES) 25851487 1 0 0 recruitment of mRNA processing factors to transcriptionally active chromatin preventing R-loops +FUS hnRNP P2 DNA-binding; Nuclear receptor co-regulator; Oncoprotein; RNA splicing; RNA-binding; SUMO LIGASE P35637 2521 16p11.2 human S42-p 3306333 QQSYSGYsQSTDTSG molecular association, regulation; protein conformation 28942918; 29610493 6 2 0 strongly reduced the effects of DNA-PK treatment on both hydrogel binding and droplet formation; precise steric regulation of the rolled-sheet amyloid fibril architecture formed by hnRNP P2 RAC1 and its potential contribution to the assembly of hnRNP P2 in RNA granules +PGR PR DNA-binding; Nuclear receptor; Transcription factor P06401 5241 11q22.1 human K183-ac 30332700 SGTAAAHkVLPRGLS Prog_receptor molecular association, regulation; phosphorylation transcription, induced DNA(INDUCES) 24302725 1 1 0 FKBP5 transcription; associated with increased S294 phosphorylation +MDM2 MDM2 EC 6.3.2.-; EC 6.3.2.19; Inhibitor; Ligase; NEDDYLATION LIGASE; Neddylation Ligase; Nucleolus; Oncoprotein; UBIQUITIN LIGASE; Ubiquitin conjugating system; Ubiquitin ligase Q00987 4193 12q15 human S386-p 11956709 DDKITQAsQSQESED molecular association, regulation; ubiquitination; enzymatic activity, inhibited; protein conformation MDM2(DISRUPTS); p53(DISRUPTS) 19816404; 21986495 3 2 0 oligomerization inhibited; phospho-mimic mutant is defective for p53 poly-ubiquitination +PLK4 PLK4 EC 2.7.11.21; KINASE; Kinase, protein; Nucleolus; Protein kinase, Other; Protein kinase, Ser/Thr (non-receptor) O00444 10733 4q28.1 human T170-p 480636 MPHEKHYtLCGTPNY Pkinase molecular association, regulation; enzymatic activity, induced STIL(INDUCES) 26101219 2 1 1 +HCST HCST Adaptor/scaffold; Membrane protein, integral Q9UBK5 10870 19q13.12 human Y86-p 23112287 AQEDGKVyINMPGRG DAP10 intracellular localization 25002577 1 1 1 recruitment of PI3K, GRB2 & GRB7 +Map3k4 MEKK4 EC 2.7.11.25; KINASE; Kinase, protein; Protein kinase, STE; Protein kinase, Ser/Thr (non-receptor) O08648 26407 17 8.42 cM|17 A1 mouse S116-p 20804890 KMNTPSQsPHKDLGK MEKK4_N molecular association, regulation; enzymatic activity, induced GADD45A(INDUCES) 27358404 1 5 0 +Plk4 PLK4 EC 2.7.11.21; KINASE; Kinase, protein; Nucleolus; Protein kinase, Other; Protein kinase, Ser/Thr (non-receptor) Q64702 20873 3|3 B mouse S297-p 12654005 LSTTITAsSGTSLSG protein degradation; ubiquitination 20100909 2 1 0 +FOXO4 FOXO4 DNA-binding; Oncoprotein; Transcription factor P98177 4303 Xq13.1 human K189-ac 459043 PEGGKSGkAPRRRAA Forkhead activity, inhibited transcription, inhibited 12964026 2 1 0 +RBM17 RBM17 RNA splicing; RNA-binding; Spliceosome Q96I25 84991 10p15.1 human S288-p 27936103 DATEKDAsKKSDSNP molecular association, regulation; phosphorylation cell motility, induced RNA(DISRUPTS) 23519612 1 0 0 induced cell invasion, enhanced Cortactin phosphorylation at ERK-dependent sites +Stk11 LKB1 Autophagy; EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, CAMK; Protein kinase, Ser/Thr (non-receptor); Tumor suppressor Q9WTK7 20869 10|10 C1 mouse Y365-p 13258701 DIEDGIIyTQDFTVP molecular association, regulation; intracellular localization; phosphorylation cell differentiation, induced; signaling pathway regulation PLCG1(INDUCES); LAT(INDUCES); Fyn(INDUCES) 20142099; 21487392; 24586906 3 0 0 TCR signaling, recruitment of PLCG1 to the LAT signalosome; mutation of this site increses AMPK phosphorylation; LKB1 cytosolic localization, induced AMPK phosphorylation +MAPK7 ERK5 EC 2.7.11.24; KINASE; Kinase, protein; Protein kinase, CMGC; Protein kinase, Ser/Thr (non-receptor) Q13164 5598 17p11.2 human Y221-p 448206 HQYFMTEyVATRWYR Pkinase cell cycle regulation; carcinogenesis, induced; cell motility, induced; apoptosis, inhibited; transcription, induced 20138986; 31980741; 34655447 20 28 955 +Pax6 PAX6 DNA-binding; Motility/polarity/chemotaxis; Transcription factor P63015 18508 2 E3|2 55.31 cM mouse T281-p 458808 QRRQASNtPSHIPIS transcription, induced 16407227 1 0 0 +NR3C1 GR DNA-binding; Mitochondrial; Nuclear receptor; Transcription factor P04150 2908 5q31.3 human T556-p 1872513510 DSSVPDStWRIMTTL Hormone_recep molecular association, regulation 14-3-3 zeta(INDUCES) 33744286 1 0 0 +FPR1 FPR1 GPCR, family 1; Membrane protein, integral; Membrane protein, multi-pass; Motility/polarity/chemotaxis; Receptor, GPCR P21462 2357 19q13.41 human S342-p 450850 ATNSTLPsAEVELQA molecular association, regulation cell motility, induced GRK2(DISRUPTS) 22447027 1 0 0 +MYO9B MYO9B Actin-binding; GAP; GAP, Rac/Rho; Motility/polarity/chemotaxis; Motor Q13459 4650 19p13.11 human T1271-p 471989 APGSAPEtPEDKSKP cell differentiation, inhibited 30872405 1 45 59 +Ap2b1 AP2B1 Vesicle P62944 140670 10q26 rat Y888-p 462927 VEGQDMLyQSLKLTN B2-adapt-app_C molecular association, regulation endocytosis, altered ARRB1(DISRUPTS); LDLRAP1(DISRUPTS) 24798335 1 6 46 phosphomimetic Y888E mutation disrupts binding +NFE2L2 NRF2 DNA-binding; Transcription factor Q16236 4780 2q31.2 human S558-p 10292703 HLLKKQLsTLYLEVF bZIP_Maf protein stabilization; intracellular localization cell differentiation, inhibited; transcription, induced 19668370; 37126714 3 2 0 +WRN WRN Cell cycle regulation; DNA repair, damage; DNA-binding; EC 3.6.4.12; Helicase; Nucleolus Q14191 7486 8p12 human S440-p 3196118 DTSYVIEsDEDLEME intracellular localization DNA repair, induced 24429382 2 17 2 localization to nucleoli, protection of cells from DSBs produced by etoposide +PRKCQ PKCT EC 2.7.11.13; KINASE; Kinase, protein; Protein kinase, AGC; Protein kinase, Ser/Thr (non-receptor) Q04759 5588 10p15.1 human T219-p 457380 SAINSREtMFHKERF intracellular localization 16252004 2 1 0 phosphorylation of site may be important in antigen receptor-mediated signaling +PDE4D PDE4D iso2 EC 3.1.4.53; Nucleotide Metabolism - purine; Phosphodiesterase Q08499-2 5144 5q11.2-q12.1 human S13-p 2188800 NFPFRRHsWICFDVD molecular association, regulation NDEL1(DISRUPTS); AKAP6(INDUCES) 15182229; 18845247 5 3 0 +Hmga2 HMGA2 DNA-binding; Oncoprotein P52927 15364 10 D2|10 67.94 cM mouse S59-p 11452900 PKGSKNKsPSKAAQK molecular association, regulation; protein conformation DNA(DISRUPTS) 10636877 1 2 0 +MORC3 MORC3 Cell cycle regulation; RNA-binding Q14149 23515 21q22.12 human K650-sm 14988619 EVPSLVVkKEETVED molecular association, regulation PML(INDUCES) 20501696 1 3 0 +TCF7L2 TCF7L2 Apoptosis; Cell cycle regulation; Cell development/differentiation; DNA-binding; Motility/polarity/chemotaxis; Transcription factor Q9NQB0 6934 10q25.2-q25.3 human T212-p 11499002 TYSNEHFtPGNPPPH CTNNB1_binding molecular association, regulation DNA(DISRUPTS) 12556497 1 0 0 Beta-catenin-TCF7L2 complex DNA binding +CDCA5 CDCA5 Cell cycle regulation Q96FF9 113130 11q13.1 human S126-p 20727702 NPEAESSsKEGELDA Sororin activity, inhibited cell cycle regulation SCC-112(DISRUPTS) 23901111 1 2 0 +APEX1 APE1 DNA repair, damage; DNA-binding; Deoxyribonuclease; EC 4.2.99.18; Endoplasmic reticulum; Hydrolase; Lyase; Nuclear receptor co-regulator; Nucleolus; Transcription, coactivator/corepressor P27695 328 14q11.2 human R301-me 1877347600 ALCDSKIrSKALGSD Exo_endo_phos molecular association, regulation TOM20(INDUCES) 32679368 1 0 0 mitochondrial translocation +TCERG1 TCERG1 RNA-binding; Spliceosome; Transcription factor O14776 10915 5q32 human K503-sm 13258711 EEPIKEIkEEPKEEE transcription, inhibited 20215116 1 2 0 sumoylation negatively regulates TCERG transcriptional activity +Chmp5 CHMP5 Cell cycle regulation; Vesicle Q9D7S9 76959 4|4 A5 mouse S30-p 36130689 TVDSRAEsIDKKISR Snf7 protein stabilization USP8(INDUCES) 28553951 1 4 0 +SHC1 SHC1 iso2 Adaptor/scaffold; Apoptosis; Mitochondrial; Motility/polarity/chemotaxis P29353-2 6464 1q21.3 human Y239-p 448509 EEPPDHQyYNDFPGK activity, induced; molecular association, regulation; activity, inhibited; phosphorylation cell growth, induced; cell motility, altered; transcription, induced; cytoskeletal reorganization GRB2(INDUCES); SHIP(INDUCES); GRB2(DISRUPTS); ZAP70(INDUCES); VAV1(INDUCES) 10598576; 10891441; 17537990; 9121430; 9710204; 9813159 32 22 947 Y317F activates MAPK; f-actin cytoskeleton, chemotaxis. +Zfp36 TTP DNA-binding; RNA-binding P22893 22695 7 A3-B1|7 16.72 cM mouse S52-p 451150 RLTGRSTsLVEGRSC activity, induced; protein stabilization; molecular association, regulation; intracellular localization; activity, inhibited translation, altered; transcription, induced 14-3-3 beta(INDUCES); CAF-1A(DISRUPTS); CAF-1B(DISRUPTS) 15014438; 16508015; 20595389; 26002976; 26019272; 31527197; 36961408 11 16 0 +CERS5 LASS5 DNA-binding; EC 2.3.1.24; Membrane protein, integral; Membrane protein, multi-pass; Transferase Q8N5B7 91012 12q13.12 human S350-p 18260879 KVSKDDRsDVESSSE enzymatic activity, induced 26887952 1 6 0 +PRKD1 PRKD1 Autophagy; EC 2.7.11.13; KINASE; Kinase, protein; Motility/polarity/chemotaxis; Protein kinase, CAMK; Protein kinase, Ser/Thr (non-receptor) Q15139 5587 14q12 human S208-p 455754 RRRLSNVsLTGVSTI molecular association, regulation 14-3-3 beta(INDUCES) 15755722 2 23 13 +Lcp2 SLP76 Adaptor/scaffold Q60787 16822 11|11 A4 mouse Y128-p 448219 DGEDDGDyESPNEEE molecular association, regulation; phosphorylation cell differentiation, altered; apoptosis, altered; cytoskeletal reorganization; cell adhesion, altered; transcription, induced; signaling pathway regulation; transcription, altered VAV1(INDUCES) 11313406; 12640123; 16456002; 18342008; 18663126; 22291096; 9047237 25 1 0 mutation of this site impairs thrombus formation; required for intergrin activation +BRSK2 BRSK2 EC 2.7.11.1; EC 2.7.11.26; KINASE; Kinase, protein; Protein kinase, CAMK; Protein kinase, Ser/Thr (non-receptor) Q8IWQ3 9024 11p15.5 human T260-p 470033 VDAARRLtLEHIQKH Pkinase enzymatic activity, induced 16870137 2 0 0 +NABP2 OBFC2B Cell cycle regulation; DNA repair, damage Q9BQ15 79035 12q13.3 human K79-sm 1877008701 KGYASVFkGCLTLYT tRNA_anti-codon protein stabilization; molecular association, regulation apoptosis, induced NBS1(INDUCES) 32576812 1 0 0 recruitment of the MRN complex to DSB sites, sumoylation enhances the sensitivity of cancer cells to DNA damage agents +Ctnnb1 CTNNB1 Actin-binding; Cell adhesion; Motility/polarity/chemotaxis; Nuclear receptor co-regulator; Oncoprotein; Transcription factor Q9WU82 84353 8q32 rat S45-p 447488 GATTTAPsLSGKGNP protein degradation 14985333 57 7 0 +Hmgcs2 HMGCS2 Amino Acid Metabolism - valine, leucine and isoleucine degradation; Carbohydrate Metabolism - butanoate; EC 2.3.3.10; Lipid Metabolism - synthesis and degradation of ketone bodies; Mitochondrial; Secondary Metabolites Metabolism - terpenoid backbone biosynthesis; Transferase P54869 15360 3 F2.2|3 42.74 cM mouse K310-sc 33339742 PFCKMVQkSLARLMF HMG_CoA_synt_C enzymatic activity, inhibited 24315375 0 2 0 K83E or K310E mutants lose enzymatic activity +FOXK2 FOXK2 DNA-binding; Transcription factor Q01167 3607 17q25.3 human S373-p 3193955 SSRSAPAsPNHAGVL protein stabilization apoptosis, altered; transcription, altered 20810654 1 24 29 +JUNB JunB Motility/polarity/chemotaxis; Oncoprotein; Transcription factor P17275 3726 19p13.13 human S79-p 454237 QGSDTGAsLKLASSE Jun activity, induced transcription, altered p300(INDUCES) 15308641 2 0 0 +P2rx3 P2X3 Channel, ligand-gated; Membrane protein, integral; Membrane protein, multi-pass P49654 81739 3q24 rat T388-p 33402211 ATVEKQStDSGAYSI activity, induced; molecular association, regulation; intracellular localization caveolin-1(INDUCES) 24755854 1 0 0 induced receptor membrane insertion, enhanced P2X3 receptor response at cell membrane +STK11 LKB1 iso2 Autophagy; EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, CAMK; Protein kinase, Ser/Thr (non-receptor); Tumor suppressor Q15831-2 6794 19p13.3 human S399-p 27933602 DLSGEEAsRPAPQ__ intracellular localization; enzymatic activity, induced 23612973 1 0 0 S399 is required for metformin activation of AMPK.; translocation from nucleus to cytosol +Trim28 TIF1B EC 6.3.2.-; KINASE; Kinase, protein; Ligase; Nuclear receptor co-regulator; Protein kinase, atypical; SUMO LIGASE; SUMO ligase; Transcription, coactivator/corepressor; UBIQUITIN LIGASE; Ubiquitin conjugating system; Ubiquitin ligase Q62318 21849 7|7 A1 mouse K575-sm 3142605 APEGPETkPVLMPLT transcription, inhibited 17298944 2 4 0 +HRH1 H1R GPCR, family 1; Membrane protein, integral; Membrane protein, multi-pass; Receptor, GPCR P35367 3269 3p25.3 human S398-p 450937 WKRLRSHsRQYVSGL 7tm_1 receptor desensitization, altered; receptor internalization, altered 10101032; 15107581; 15328002 4 0 0 +Kcnj10 Kir4.1 Channel, ligand-gated; Channel, potassium; Membrane protein, integral; Membrane protein, multi-pass P49655 29718 13q24 rat S377-p 2243103 SALSVRIsNV_____ molecular association, regulation; intracellular localization MAGI1(DISRUPTS) 18303016 1 1 0 +Ctnnb1 CTNNB1 Actin-binding; Cell adhesion; Motility/polarity/chemotaxis; Nuclear receptor co-regulator; Oncoprotein; Transcription factor Q02248 12387 9 F4|9 72.19 cM mouse Y86-p 447584 VADIDGQyAMTRAQR intracellular localization transcription, induced 27572314 9 1 22 translocation to nucleus +ACTB ACTB Cytoskeletal; Motility/polarity/chemotaxis P60709 60 7p22.1 human K68-m3 1877292603 KRGILTLkYPIEHGI Actin cell motility, induced; cytoskeletal reorganization 33008892 2 1 0 +PPM1G PPM1G EC 3.1.3.16; Motility/polarity/chemotaxis; PHOSPHATASE; Protein phosphatase, Ser/Thr (non-receptor); Spliceosome O15355 5496 2p23.3 human S183-p 460849 GTGEEPGsQGLNGEA molecular association, regulation RNA(INDUCES) 26324325 1 12 67 +SIAH2 SIAH2 EC 6.3.2.-; EC 6.3.2.19; Ligase; Transcription, coactivator/corepressor; UBIQUITIN LIGASE; Ubiquitin conjugating system; Ubiquitin ligase O43255 6478 3q25.1 human T119-p 26371004 PTCRGALtPSIRNLA protein degradation; intracellular localization; enzymatic activity, induced cytoskeletal reorganization 22878263; 23044042; 26751770 3 3 0 +SOX2 SOX2 Cell development/differentiation; DNA-binding; Transcription factor P48431 6657 3q26.33 human S250-p 6738003 VVKSEASsSPPVVTS molecular association, regulation cell cycle regulation; cell differentiation, induced Oct4(INDUCES) RNA(INDUCES) 34497381 1 4 0 +Dab1 DAB1 iso2 Adaptor/scaffold P97318-2 13131 4 C6|4 47.79 cM mouse S481-p 479420 STTPSTNsPPTPAPR phosphorylation 16529723 1 0 0 inhibits tyrosine phosphorylation +Axin1 axin 1 Adaptor/scaffold; Tumor suppressor O70239 79257 10q12 rat S325-p 2226510 ANDSEQQsLSSDADT cytoskeletal reorganization 22933777 1 0 0 Phosphorylation regulates responsive to Sema3A induced growth cone collapse. +BRSK2 BRSK2 EC 2.7.11.1; EC 2.7.11.26; KINASE; Kinase, protein; Protein kinase, CAMK; Protein kinase, Ser/Thr (non-receptor) Q8IWQ3 9024 11p15.5 human T443-p 17551641 PRGSPLPtPKGTPVH enzymatic activity, inhibited 23629625 2 2 0 +STAT2 STAT2 DNA-binding; Transcription factor P52630 6773 12q13.3 human S393-p 1869778702 LTPEKGQsQGLIWDF STAT_bind protein degradation; molecular association, regulation; ubiquitination carcinogenesis, inhibited; cell growth, inhibited; signaling pathway regulation FBXW7(INDUCES) 31843895 1 0 0 by FBXW7 interaction; FBXW7-STAT2 interaction regulate melanoma cell and colony growth +SNAI2 Snail2 Apoptosis; C2H2-type zinc finger protein; Motility/polarity/chemotaxis; Transcription factor O43623 6591 8q11.21 human S54-p 31961400 ILSSGAYsPITVWTT protein degradation; ubiquitination cell cycle regulation 24662826 1 0 0 +Dusp8 DUSP8 EC 3.1.3.16; EC 3.1.3.48; Motility/polarity/chemotaxis; PHOSPHATASE; Protein phosphatase, dual-specificity O09112 18218 7 F5|7 87.59 cM mouse S515-p 22598803 GWVPPLDsPGTPSPD enzymatic activity, inhibited signaling pathway regulation 22100391 1 1 0 activates JNK pathway +PTPN7 HePTP EC 3.1.3.48; Motility/polarity/chemotaxis; PHOSPHATASE; Protein phosphatase, tyrosine (non-receptor) P35236 5778 1q32.1 human S246-p 460715 QYQEERRsVKHILFS Y_phosphatase intracellular localization; enzymatic activity, induced 16479000 1 0 0 inhibits TCR-induced gene activation +SLC6A3 DAT Membrane protein, integral; Membrane protein, multi-pass; Transporter; Transporter, SLC family Q01959 6531 5p15.33 human S13-p 451138 CSVGLMSsVVAPAKE activity, induced 16908408 4 0 0 stimulates DAT-mediated efflux of dopamine +RET Ret EC 2.7.10.1; KINASE; Kinase, protein; Membrane protein, integral; Oncoprotein; Protein kinase, TK; Protein kinase, tyrosine (receptor) P07949 5979 10q11.21 human S696-p 451267 SSGARRPsLDSMENQ molecular association, regulation; enzymatic activity, induced cytoskeletal reorganization 11886862; 20682772 5 7 0 regulation of Rac activation and GDNF induced lamellipodia formation.; inhibits interaction of SHP2 with Ret Y687 +Rnd3 RhoE G protein; G protein, monomeric; G protein, monomeric, Rho; Motility/polarity/chemotaxis P61588 74194 2|2 C1.1 mouse K235-ub 40212800 AVATDLRkDKAKSCT protein degradation cell cycle regulation 24045951 1 0 0 +BRD4 BRD4 KINASE; Kinase, protein; Protein kinase, Ser/Thr (non-receptor); Protein kinase, atypical O60885 23476 19p13.12 human R183-m1 57691848 AKGRGRGrKETGTAK carcinogenesis, induced; DNA repair, induced; cell growth, induced; transcription, induced 36475791 1 2 0 +Steap4 STEAP4 EC 1.16.1.-; Membrane protein, integral; Membrane protein, multi-pass; Oxidoreductase Q923B6 117167 5|5 A1 mouse K18-ub 27211122 LTTDSSEkQGVVCIF protein degradation 35747386 1 2 0 +DRD2 DRD2 GPCR, family 1; Membrane protein, integral; Membrane protein, multi-pass; Receptor, GPCR P14416 1813 11q23.2 human K258-ub 1877221609 KLCTVIMkSNGSFPV 7tm_1 protein degradation 32572597 1 0 0 +MEF2D MEF2D DNA-binding; Transcription factor Q14814 4209 1q22 human S98-p 470518 KGFNGCDsPEPDGED HJURP_C molecular association, regulation; ubiquitination SKP2(INDUCES) 25733682 2 24 5 +Sh3glb1 endophilin B1 Apoptosis; Autophagy; EC 2.3.1.-; Mitochondrial; Transferase Q9JK48 54673 3|3 H2 mouse T145-p 26318403 TSALNFLtPLRNFIE BAR molecular association, regulation; protein conformation autophagy, induced beclin 1(INDUCES); UVRAG(INDUCES) 21499257 2 0 0 dimerization; neuronal cell loss +Syngap1 SynGAP GAP; GAP, Ras F6SEU4 240057 17|17 A3.3 mouse S857-p 37045603 GPGGRLNsSSVSNLA DUF3498 activity, induced 25533468 1 1 0 phosphorylation of this site increases HRas GAP activity of S88A/T790A/S817A SunGAP mutant +PLCB1 PLCB1 Carbohydrate Metabolism - inositol phosphate; EC 3.1.4.11; Phospholipase Q9NQ66 23236 20p12.3 human S887-p 450172 HSQPAPGsVKAPAKT intracellular localization 21338571 3 1 0 +F2RL1 F2RL1 GPCR, family 1; Membrane protein, integral; Membrane protein, multi-pass; Receptor, GPCR P55085 2150 5q13.3 human S388-p 15409901 RKSSSYSsSSTTVKT receptor desensitization, induced; molecular association, regulation; phosphorylation signaling pathway regulation ARRB1(INDUCES); ARRB2(INDUCES) 33073187 1 0 3 inhibits ERK phosphorylation and signaling; regulates calcium signaling +RYR1 RYR1 Channel, calcium; Membrane protein, integral; Membrane protein, multi-pass; Transporter; Transporter, ion channel P11716 100009540 rabbit S2843-p 451818 KKKTRKIsQTAQTYD molecular association, regulation CAMK2B(INDUCES) 22913516 12 8 0 20% reduction in binding with S2843A mutant +H3C14 HIST2H3A/C/D DNA-binding Q71DI3 126961 1q21.2 human K9-ac 18465124 RTKQTARkSTGGKAP Histone chromatin organization, altered; transcription, induced 20075197 1 5 55 +OFD1 OFD1 Cell cycle regulation O75665 8481 Xp22.2 human S735-p 480374 GTSSRRLsSTPLPKA protein degradation; molecular association, regulation; ubiquitination transcription, induced; cytoskeletal reorganization; signaling pathway regulation WDR67(INDUCES) 33934390 1 13 12 induces SHH pathway +orf9b Accessory protein 9b P0DTD2 SARSCoV2 K4-ub 1883454306 ____MDPkISEMHPA protein degradation; ubiquitination 35638730 1 0 0 reduces ORF9b-mediated IFN and NF-kB inhibition +HAVCR1 TIM-1 Membrane protein, integral Q96D42 26762 5q33.3 human Y355-p 20842101 VQAEDNIyIENSLYA receptor internalization, altered; intracellular localization 29321304 2 0 7 receptor surface of 350A mutant, 350A mutant enhanced HCV infection +EPHA4 EphA4 EC 2.7.10.1; KINASE; Kinase, protein; Membrane protein, integral; Protein kinase, TK; Protein kinase, tyrosine (receptor) P54764 2043 2q36.1 human Y779-p 450858 EDDPEAAyTTRGGKI PK_Tyr_Ser-Thr enzymatic activity, induced 21439481 2 33 700 +Jak2 JAK2 EC 2.7.10.2; KINASE; Kinase, protein; Oncoprotein; Protein kinase, TK; Protein kinase, tyrosine (non-receptor) Q62120 16452 19 C1|19 23.73 cM mouse S523-p 465671 GISDVQIsPTLQRHN enzymatic activity, inhibited; phosphorylation 16705159; 16705160; 19364823 4 21 1 +Sdc4 syndecan-4 Cell adhesion; Membrane protein, integral; Motility/polarity/chemotaxis P34901 24771 3q42 rat S183-p 449863 MKKKDEGsYDLGKKP Syndecan protein conformation cell adhesion, induced; cell motility, inhibited 16310216; 22504297 11 1 0 decreased Rho A activation +IKZF1 Ikaros C2H2-type zinc finger protein; DNA-binding; Transcription factor Q13422 10320 7p12.2 human S364-p 4714822 GTPRSNHsAQDSAVE molecular association, regulation; intracellular localization cell differentiation, induced; transcription, induced DNA(INDUCES) 23071339 1 8 0 induces transcription of DNAJC6, EIF4e3, TNFAIP8L2; nuclear localization +RPL11 RPL11 Motility/polarity/chemotaxis; Nucleolus; Ribosomal; Translation P62913 6135 1p36.11 human K52-ne 12067604 GQTPVFSkARYTVRS Ribosomal_L5 protein stabilization; intracellular localization 19713960 1 0 0 +Jak2 JAK2 EC 2.7.10.2; KINASE; Kinase, protein; Oncoprotein; Protein kinase, TK; Protein kinase, tyrosine (non-receptor) Q62120 16452 19 C1|19 23.73 cM mouse Y1008-p 448408 LPQDKEYyKVKEPGE PK_Tyr_Ser-Thr ubiquitination; enzymatic activity, induced carcinogenesis, induced; cell growth, induced; signaling pathway regulation 16705159; 16705160; 18160720; 20304997; 21685897; 24614172; 33539470; 36356831; 36400972 77 2 16 +ZAP70 ZAP70 EC 2.7.10.2; KINASE; Kinase, protein; Protein kinase, TK; Protein kinase, tyrosine (non-receptor) P43403 7535 2q11.2 human Y474-p 455368 VLLVNRHyAKISDFG PK_Tyr_Ser-Thr activity, induced; molecular association, regulation SHC1(INDUCES) 9685404 1 0 3 +Kcnj4 HIR Channel, potassium; Membrane protein, integral; Membrane protein, multi-pass P52190 116649 7q34 rat S444-p 9819904 NISYRREsAI_____ molecular association, regulation TAX1BP3(DISRUPTS) 19635485 1 0 0 +TOPORS TOPORS Cell cycle regulation; EC 6.3.2.-; EC 6.3.2.19; Ligase; SUMO LIGASE; SUMO conjugating system; SUMO ligase; UBIQUITIN LIGASE; Ubiquitin conjugating system; Ubiquitin ligase Q9NS56 10210 9p21.1 human S718-p 5938002 KDRDGYEsSYRRRTL protein degradation; sumoylation; ubiquitination; enzymatic activity, altered cell cycle regulation 19473992; 19821153; 26872363 3 2 0 +PPARGC1A PGC-1 alpha Nuclear receptor co-regulator; Transcription, coactivator/corepressor Q9UBK2 10891 4p15.2 human K278-ac 63355301 KGSPFENkTIERTLS transcription, inhibited 28340340 0 1 0 +Foxo3 FOXO3A Autophagy; DNA-binding; Oncoprotein; Transcription factor Q9WVH4 56484 10 B2|10 22.79 cM mouse S208-p 464289 SSAGWKNsIRHNLSL Forkhead protein stabilization 24453252 4 0 0 +RIF1 RIF1 DNA repair, damage Q5UIP0 55183 2q23.3 human S2205-p 3201699 VNKVRRVsFADPIYQ molecular association, regulation; enzymatic activity, inhibited cell cycle regulation PPP2R2C(DISRUPTS); PPP2R3B(INDUCES); PPP2R5C(DISRUPTS); PPP2R3A(INDUCES) 31209037; 32900880 5 20 77 +PSEN1 PSEN1 Cell surface; EC 3.4.23.-; Membrane protein, integral; Membrane protein, multi-pass; Mitochondrial; Protease P49768 5663 14q24.2 human S366-p 3191056 AAVQELSsSILAGED Presenilin protein conformation 28132667 1 14 0 PS1 pathogenic conformational shift +Ephb2 EphB2 EC 2.7.10.1; KINASE; Kinase, protein; Membrane protein, integral; Protein kinase, TK; Protein kinase, tyrosine (receptor); Tumor suppressor P54763 13844 4 D3|4 69.0 cM mouse Y742-p 448330 KYLADMNyVHRDLAA PK_Tyr_Ser-Thr protein conformation 16977320 3 4 0 modulates conformation of the activation section of EphB2 (residues Y604-Y610) +Pparg PPAR-gamma iso2 DNA-binding; Nuclear receptor; Transcription factor P37238-2 19016 6 E3|6 53.41 cM mouse K365-sm 12004433 FGDFMEPkFEFAVKF Hormone_recep molecular association, regulation transcription, altered; transcription, inhibited HDAC3(INDUCES); N-CoR1(INDUCES) 16127449; 23826177 8 0 0 necessary for ligand-induced reduction of sumoylation +Nr0b2 NR0B2 Nuclear receptor; Nuclear receptor co-regulator; Transcription, coactivator/corepressor Q62227 23957 4 D2.3|4 66.25 cM mouse T58-p 28702400 RLCAPHRtCREALDV Hormone_recep molecular association, regulation; intracellular localization autophagy, induced; transcription, induced SREBP-2(INDUCES); AHR(INDUCES) DNA(INDUCES) 26634251; 35686465; 37348559 4 0 0 +PLCG2 PLCG2 Carbohydrate Metabolism - inositol phosphate; EC 3.1.4.11; Motility/polarity/chemotaxis; Phospholipase P16885 5336 16q23.3 human T1045-p 25692905 LQPESMRtEKYDPMP signaling pathway regulation 22759789 1 0 0 B cell receptor signaling +TOP2A TOP2A EC 5.99.1.3; Isomerase P11388 7153 17q21.2 human S1247-p 452238 KNENTEGsPQEDGVE sumoylation; intracellular localization cell cycle regulation 30871006 2 63 4 +CGAS cGAS EC 2.7.7.86 Q8N884 115004 6q13 human K414-ac 11322517 KDCLKLMkYLLEQLK Mab-21_C enzymatic activity, inhibited; protein conformation; activity, inhibited apoptosis, inhibited 30799039; 32345711; 33438687 3 3 0 +Camk2b CAMK2B EC 2.7.11.17; KINASE; Kinase, protein; Protein kinase, CAMK; Protein kinase, Ser/Thr (non-receptor) P08413 24245 14q21 rat T382-p 48915804 AALEPQTtVIHNPVD molecular association, regulation 26291163 1 2 0 inhibits interaction with F-actin, regulates synaptic plasticity +MDM2 MDM2 EC 6.3.2.-; EC 6.3.2.19; Inhibitor; Ligase; NEDDYLATION LIGASE; Neddylation Ligase; Nucleolus; Oncoprotein; UBIQUITIN LIGASE; Ubiquitin conjugating system; Ubiquitin ligase Q00987 4193 12q15 human S242-p 454921 WLDQDSVsDQFSVEF activity, induced 12167711 3 1 0 promotes p53 degradation +Sstr2 SSTR2 GPCR, family 1; Membrane protein, integral; Membrane protein, multi-pass; Receptor, GPCR P30680 rat T353-p 7652102 DKSRLNEtTETQRTL activity, induced; intracellular localization; receptor internalization, altered signaling pathway regulation 21493671; 21795688 9 0 1 Dephosphorylation is initiated directly after receptor activation at or near the plasma membrane; leads to disruption of the ?-arrestin- GPCR complex +H1-2 H1C DNA-binding P16403 3006 6p22.2 human T165-p 18910728 AKKPAAAtVTKKVAK cell growth, altered 24873882 1 3 0 +Dzip1 DZIP1 C2H2-type zinc finger protein Q8BMD2 66573 14|14 E4 mouse S714-p 21241900 DTDWTEGsEMDDSDF transcription, induced; signaling pathway regulation 21878643 1 1 0 involved in Gli1 nad Gli3 turnover pathway +TLN1 talin 1 Cytoskeletal; Motility/polarity/chemotaxis Q9Y490 7094 9p13.3 human K2454-me 1873284342 DQDSEAMkRLQAAGN I_LWEQ carcinogenesis, induced; cell growth, induced; cytoskeletal reorganization; cell adhesion, altered VAV1(INDUCES) 28967906 1 0 0 induces STAT3 activation and phosphorylation +RCHY1 RCHY1 EC 6.3.2.-; EC 6.3.2.19; Nuclear receptor co-regulator; UBIQUITIN LIGASE; Ubiquitin conjugating system; Ubiquitin ligase Q96PM5 25898 4q21.1 human T154-p 483981 ICLEDIHtSRVVAHV zf-RING_2 ubiquitination; intracellular localization; enzymatic activity, inhibited cell growth, altered p53(DISRUPTS) 17568776 1 1 0 cytoplasmic localization +Tbc1d1 TBC1D1 DEUBIQUITINASE; GAP; GAP, Rab; Ubiquitin-specific protease Q60949 57915 5 C3.1|5 32.8 cM mouse S501-p 3996102 AKRSLTEsLESILSR activity, inhibited 19740738 1 10 2 reduces inhibitory effect on TBC1D1 on GLUT4 translocation +STARD3 STARD3 Membrane protein, integral; Membrane protein, multi-pass Q14849 10948 17q12 human S213-p 12738030 QFYSPPEsFAGSDNE MENTAL molecular association, regulation VAPA(INDUCES) 35231443 1 3 0 +POLM POLM DNA repair, damage; EC 2.7.7.7; Transferase Q9NP87 27434 7p13 human S372-p 28758702 HQHSCCEsPTRLAQQ DNA_pol_B_palm molecular association, regulation; enzymatic activity, inhibited; protein conformation DNA(DISRUPTS) 23933132; 31138645 2 0 0 Increase the stability of Loop1 +BACE1 BACE EC 3.4.23.46; Membrane protein, integral; Protease P56817 23621 11q23.3 human K126-ac 478256 STYRDLRkGVYVPYT Asp protein stabilization; intracellular localization 17425515 1 1 1 regulates translocation through secretory pathway +PRPF3 PRPF3 RNA processing; RNA splicing; Spliceosome O43395 9129 1q21.2 human K559-sm 1872852110 SNPAKKFkIEANAGQ DUF1115 molecular association, regulation RNA splicing, induced EFTUD2(INDUCES); SF3A1(INDUCES); PRP4(INDUCES) 28379520 1 0 0 +HMGN1 HMGN1 DNA-binding; Nuclear receptor co-regulator P05114 3150 21q22.2 human K61-ac 458853 GKRGAKGkQAEVANQ HMG14_17 molecular association, regulation DNA(DISRUPTS) 10753971 1 2 0 +PGR PR DNA-binding; Nuclear receptor; Transcription factor P06401 5241 11q22.1 human S676-p 450154 LSQRFTFsPGQDIQL transcription, induced 8662865 2 2 0 +SRF SRF Motility/polarity/chemotaxis; Transcription factor P11831 6722 6p21.1 human S251-p 13203802 TDLTYQVsESDSSGE transcription, inhibited 8375385 1 0 0 +Snap25 SNAP-25 Vesicle P60881 25012 3q36 rat T138-p 449875 GGFIRRVtNDARENE SNAP-25 molecular association, regulation neural plasticity; exocytosis, inhibited; signaling pathway regulation STX1A(DISRUPTS) 26721188; 30728295 7 5 3 +DNAJB8 DNAJB8 Chaperone Q8NHS0 165721 3q21.3 human K216-ac 12615902 VEEDGQLkSVTVNGK activity, induced 20159555 1 1 0 +NRIP1 RIP140 Nuclear receptor co-regulator; Transcription, coactivator/corepressor P48552 8204 21q11.2-q21.1 human K756-sm 2798318 QILMVKIkSEPCDDL NRIP1_repr_3 intracellular localization transcription, inhibited 18211901 1 1 0 +CCDC6 CCDC6 Apoptosis; Cytoskeletal; Oncoprotein Q16204 8030 10q21.2 human K266-sm 27992503 MRHIRFLkNEVERLK DUF2046 intracellular localization transcription, induced; signaling pathway regulation 23145146 1 0 0 cyclic AMP activity +TGFB1I1 Hic-5 Motility/polarity/chemotaxis; Nuclear receptor co-regulator; Transcription, coactivator/corepressor O43294 7041 16p11.2 human Y60-p 450964 SGDKDHLySTVCKPR Paxillin molecular association, regulation; activity, inhibited transcription, altered SH2D1B(NOT_REPORTED); CSK(INDUCES); AR(DISRUPTS) 10838081; 11856738; 23322602 3 7 20 +CTDSP1 CTDSP1 EC 3.1.3.16; PHOSPHATASE; Protein phosphatase, Ser/Thr (non-receptor) Q9GZU7 58190 2q35 human S245-p 40684504 LPFFEQLsRVDDVYS NIF enzymatic activity, inhibited cell growth, inhibited 25893300 1 0 0 +Mark2 MARK2 EC 2.7.11.1; EC 2.7.11.26; KINASE; Kinase, protein; Protein kinase, CAMK; Protein kinase, Ser/Thr (non-receptor) O08679 60328 1q43 rat T539-p 453427 RGVSSRStFHAGQLR enzymatic activity, inhibited 16717194 5 19 1 +Pxn PXN Adaptor/scaffold; Cell adhesion; Cytoskeletal; Motility/polarity/chemotaxis Q8VI36 19303 5 F|5 56.1 cM mouse S126-p 450227 SFPNKQKsAEPSPTV Paxillin cell motility, altered; cytoskeletal reorganization 16537926 8 28 4 regulates cells spreading +KCNA5 Kv1.5 Channel, potassium; Membrane protein, integral; Membrane protein, multi-pass P22460 3741 12p13.32 human S592-p 1269647506 KCNVKAKsNVDLRRS activity, inhibited 30279167 1 0 0 mediates HPV +Ghr GH receptor Membrane protein, integral; Receptor, cytokine P16310 25235 2q16 rat Y487-p 450479 SLANIDFyAQVSDIT GHBP molecular association, regulation SHP-2(INDUCES) 10976913 2 0 0 Minor SHP-2 interacting phosphorylation site. +VCP VCP Chaperone; DNA repair, damage; EC 3.6.4.6; Endoplasmic reticulum; Hydrolase P55072 7415 9p13.3 human S664-p 7435526 LKANLRKsPVAKDVD molecular association, regulation; intracellular localization; phosphorylation cell cycle regulation OTUB1(INDUCES); CLN3(INDUCES) 29950310 1 2 0 Cdc48 in the stabilization of Cln3 in the nucleus, regulates G1-cyclin activity for cell cycle entry, enhanced pRB phosphorylation +FYB2 ARAP Adaptor/scaffold Q5VWT5 199920 1p32.2 human Y491-p 56614902 SSISEEIyDDVEYSR molecular association, regulation; intracellular localization signaling pathway regulation SLP76(INDUCES) 27335501 1 0 0 +Bid BID Apoptosis; Mitochondrial P70444 12122 6 F1|6 57.02 cM mouse S78-p 456957 RIEPDSEsQEEIIHN BID cell cycle regulation; apoptosis, induced; apoptosis, inhibited 16122425; 16122426; 24767991 6 6 0 +Erbb2 HER2 EC 2.7.10.1; KINASE; Kinase, protein; Membrane protein, integral; Oncoprotein; Protein kinase, TK; Protein kinase, tyrosine (receptor) P06494 24337 10q31 rat Y1250-p 447614 PTAENPEyLGLDVPV molecular association, regulation cell growth, altered EGFR(INDUCES); Chk1(INDUCES) 1354355; 15163624; 9461599 60 15 200 +CREM CREM DNA-binding; Transcription factor Q03060 1390 10p11.21 human S277-p 450066 ASPGSLHsPQQLAEE protein degradation; ubiquitination 11466319 4 12 1 +Elavl4 ELAVL4 RNA-binding O09032 432358 5q35 rat R248-me 478333 PLHHQAQrFRLDNLL cell growth, induced 16508003 1 0 0 +NRAS NRas G protein; G protein, monomeric; G protein, monomeric, Ras; Motility/polarity/chemotaxis; Oncoprotein P01111 4893 1p13.2 human Y32-p 15228782 QNHFVDEyDPTIEDS Ras molecular association, regulation; activity, inhibited RASA1(INDUCES); RALA(INDUCES) 25157176; 26617336 2 4 8 +Myb Myb DNA-binding; Oncoprotein; Transcription factor P06876 17863 10 A3|10 9.75 cM mouse S556-p 1308923 TQLFSQAsPVADAPN protein degradation 18006338 1 0 0 stress-induced degredation +EGLN2 EGLN2 EC 1.14.11.29; Oxidoreductase Q96KS0 112398 19q13.2 human S132-p 4213804 GGDAPSPsKRPWARQ enzymatic activity, inhibited 18710826 1 0 0 +CDC7 CDC7 EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, Other; Protein kinase, Ser/Thr (non-receptor) O00311 8317 1p22.2-p22.1 human T472-p 23092186 LRGMDSStPKLTSDI Pkinase protein degradation; ubiquitination 27611229 1 0 1 +SUMO1 SUMO1 Nuclear receptor co-regulator; Ubiquitin-like modifier P63165 7341 2q33.1 human T76-p 15178384 QRIADNHtPKELGME Rad60-SLD sumoylation; protein stabilization cell growth, induced; transcription, induced 25867063 1 2 0 induces global sumoylation +Arhgef7 ARHGEF7 GEF; GEF, Rac/Rho; Motility/polarity/chemotaxis O55043 114559 16q12.5 rat S71-p 3573357 KPSEKPVsPKSGTLK molecular association, regulation; protein conformation 14-3-3 beta(INDUCES); NEDD4 iso2(INDUCES) 31566435 1 31 0 Regulates ENaC activity +ITGB4 ITGB4 iso2 Cell adhesion; Membrane protein, integral; Motility/polarity/chemotaxis; Receptor, misc. P16144-2 3691 17q25.1 human Y1642-p 450143 GLSENVPyKFKVQAR fn3 molecular association, regulation cell adhesion, altered SHC1(INDUCES) 11044453 1 0 0 +FGF14 FGF14 Cell development/differentiation; Cytokine Q92915 2259 13q33.1 human S230-p 54201600 VTPSKSTsASAIMNG activity, induced; intracellular localization SCN2A(INDUCES); SCN8A(INDUCES) 26917740 1 1 0 axodendritic polarity, FGF14 modulation of Nav mediated currents +RND3 RhoE G protein; G protein, monomeric; G protein, monomeric, Rho; Motility/polarity/chemotaxis P61587 390 2q23.3 human S11-p 455489 RRASQKLsSKSIMDP protein stabilization; intracellular localization 15775972 1 0 0 +KLC2 KLC2 Microtubule-binding; Motor Q9H0B6 64837 11q13.2 human S582-p 452949 PRMKRASsLNFLNKS molecular association, regulation 14-3-3 beta(INDUCES) 21725060 2 75 63 mutation of this site prevents 14-3-3 binding (pan-14-3-3 antibody) +BAZ1B WSTF DNA replication; EC 2.7.10.2; KINASE; Kinase, protein; Nuclear receptor co-regulator; Protein kinase, Ser/Thr (non-receptor); Protein kinase, tyrosine (non-receptor) Q9UIG0 9031 7q11.23 human S158-p 3215310 KSDGACDsPSSDKEN molecular association, regulation; phosphorylation; enzymatic activity, induced carcinogenesis, induced; cell growth, induced; transcription, induced H2AX(INDUCES) 19776015; 32518374 3 14 5 promotes phosphorylation of WSTF at S158 +Ptpn6 SHP-1 EC 3.1.3.48; Motility/polarity/chemotaxis; PHOSPHATASE; Protein phosphatase, tyrosine (non-receptor) P29351 15170 6 F2|6 59.17 cM mouse Y564-p 448912 SKHKEEVyENVHSKS enzymatic activity, induced cell growth, altered 20858858 18 19 776 +TAOK1 TAO1 EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, STE; Protein kinase, Ser/Thr (non-receptor) Q7L7X3 57551 17q11.2 human S990-p 3627517 SRSTSVTsQISNGSH activity, induced cell cycle regulation 17396146 1 0 5 +MKNK1 Mnk1 EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, CAMK; Protein kinase, Ser/Thr (non-receptor); Translation Q9BUB5 8569 1p33 human T250-p 447621 NSCTPITtPELTTPC Pkinase enzymatic activity, induced apoptosis, inhibited; cell growth, altered 17130135; 17590453; 18299328 14 1 1 Disruption of Mnk1 Mnk2 enhances As2O4 inducedapoptosis. +KIT Kit EC 2.7.10.1; KINASE; Kinase, protein; Membrane protein, integral; Oncoprotein; Protein kinase, TK; Protein kinase, tyrosine (receptor) P10721 3815 4q12 human Y568-p 448014 EEINGNNyVYIDPTQ activity, induced; protein degradation; molecular association, regulation; receptor internalization, altered; enzymatic activity, induced; phosphorylation cell growth, altered CTK(INDUCES); Src(INDUCES); APS(INDUCES); SHP-2(INDUCES); CBL(INDUCES) 12444928; 12878163; 16780420; 20147452; 21887372; 9038210; 9528781 13 3 18 +BBC3 PUMA Apoptosis; Mitochondrial Q9BXH1 27113 19q13.32 human S96-p 18610001 RPDGPQPsLSLAEQH PUMA molecular association, regulation; intracellular localization MPC1(INDUCES) 30712844 2 0 0 PUMA interacts with MPC and distrupts the oligomerization of MPC1 and MPC2 +DES desmin Cytoskeletal; Motility/polarity/chemotaxis P17661 1674 2q35 human S60-p 449614 VYQVSRTsGGAGGLG Filament_head intracellular localization cytoskeletal reorganization 12686604 2 7 0 Mutated desmin sites showed failure of desmin filaments to segregate into daughter cells. ; Phosphorylated at the clevage furrow during cytokinesis. +ATG9A ATG9A Autophagy; Membrane protein, integral; Membrane protein, multi-pass; Vesicle Q7Z3C6 79065 2q35 human S14-p 3203970 EYQRLEAsYSDSPPG autophagy, induced 27934868 1 14 16 +Pdcd4 PDCD4 Apoptosis; Tumor suppressor Q61823 18569 19 D2|19 48.73 cM mouse S94-p 472106 SGVAVPTsPKGRLLD translation, inhibited 28644433 1 57 46 +MRNIP MRNIP Unknown function Q6NTE8 51149 5q35.3 human S100-p 57812704 NVKQQEKsQPSESRW MRNIP intracellular localization 27568553 1 0 0 +Ceacam1 CEACAM1 Cell adhesion; Immunoglobulin superfamily; Membrane protein, integral; Motility/polarity/chemotaxis P16573 81613 1q21 rat Y488-p 447777 NKVDDVSySVLNFNA activity, induced 7518458; 7626603 10 2 0 phosphorylation of this site may regulate the kinetics of bile acid efflux activity of CEACAM1; Phosphorylation of CEACAM1 induces Ca2+/Mg2+-dependent ecto ATPase activity. +BCAR1 P130Cas Adaptor/scaffold; Motility/polarity/chemotaxis P56945 9564 16q23.1 human Y165-p 448722 PSPATDLyQVPPGPG activity, induced carcinogenesis, induced; cell motility, induced; cell adhesion, induced; cytoskeletal reorganization 22084245; 34169835 13 1 0 +TTK TTK Cancer Testis Antigen (CTA); EC 2.7.12.1; KINASE; Kinase, protein; Protein kinase, Other; Protein kinase, dual-specificity (non-receptor) P33981 7272 6q14.1 human T458-p 15428764 CKTPSSNtLDDYMSC intracellular localization; enzymatic activity, induced 26119734 1 0 1 regulates spindle assembly checkpoint and recruitment of SAC proteins +OTC OTC Amino Acid Metabolism - arginine and proline; EC 2.1.3.3; Mitochondrial; Transferase P00480 5009 Xp11.4 human K88-ac 467097 SLGMIFEkRSTRTRL OTCace_N enzymatic activity, inhibited 19318352 1 7 30 +HABP4 HABP4 Transcription regulation Q5JVS0 22927 9q22.32 human K276-sm 1873147502 PEEESPAkVPELEVE HABP4_PAI-RBP1 molecular association, regulation 28695742 1 0 0 Presence of SUMO-1 strongly influences the interaction of HABP4 (Ki-1/57) with other cellular proteins.; Fewer PML-nuclear bodies when compared to non-SUMOylated triple mutants, but not when treated with As2O2 +COX5B COX5B EC 1.9.3.1; Energy Metabolism - oxidative phosphorylation; Mitochondrial; Oxidoreductase P00428 cow S33-p 25265505 SVVRSMAsGGGVPTD COX5B enzymatic activity, inhibited 22522801 0 1 0 +NR3C2 MCR DNA-binding; Nuclear receptor P08235 4306 4q31.23 human K953-sm 3144807 FRESHALkVEFPAML transcription, induced; transcription, inhibited 14500761; 17105732 3 0 0 Ubc9 can be a transcriptional mineralocorticoid receptor coactivator. +INSR INSR iso2 EC 2.7.10.1; KINASE; Kinase, protein; Membrane protein, integral; Protein kinase, TK; Protein kinase, tyrosine (receptor) P06213-2 3643 19p13.2 human Y1343-p 447683 SLGFKRSyEEHIPYT activity, inhibited cell cycle regulation 2026614 15 5 2 +NCF1 p47phox EC 1.-.-.-; Oxidoreductase P14598 653361 7q11.23 human S320-p 451726 QRSRKRLsQDAYRRN NECFESHC molecular association, regulation; enzymatic activity, induced signaling pathway regulation CYBA(INDUCES) 12056906; 31736979; 35108370 13 10 8 LPS-induced activation of p38MAPK and ERK1/2 signaling pathways +ACTN4 ACTN4 Cytoskeletal; Motility/polarity/chemotaxis O43707 81 19q13.2 human Y31-p 11498502 GGGSMGDyMAQEDDW molecular association, regulation; intracellular localization; protein conformation; phosphorylation apoptosis, induced; cell motility, inhibited; cytoskeletal reorganization; cell growth, altered ACTA1(DISRUPTS); ACTB(DISRUPTS) 19920151; 26012634; 31664084 5 1 0 +Nrip1 RIP140 Nuclear receptor co-regulator; Transcription, coactivator/corepressor Q8CBD1 268903 16|16 C3.1 mouse K932-ac 459041 RSWARESkSFNVLKQ NRIP1_repr_4 intracellular localization transcription, inhibited 15879431 0 2 0 +Gria4 GluR4 Channel, ligand-gated; Membrane protein, integral; Membrane protein, multi-pass P19493 29629 8q11 rat S862-p 448810 TRNKARLsITGSVGE receptor internalization, altered; intracellular localization 12536214 6 4 1 +MBD4 MBD4 Apoptosis; DNA repair, damage; Deoxyribonuclease; EC 3.2.2.- O95243 8930 3q21.3 human K215-sm 1877787601 TSTHLLLkEDEGVDD DNA repair, induced 31476572 1 1 0 +GLI3 GLI3 C2H2-type zinc finger protein; Transcription factor P10071 2737 7p14.1 human K779-ub 6097712 TKWMEHVkLERLKQV protein processing 16705181 1 0 0 +Grid2 GluR-delta2 Channel, calcium; Channel, ligand-gated; Membrane protein, integral; Membrane protein, multi-pass Q63226 79220 4q31 rat S945-p 3595502 QTLSRTLsAKAASGF molecular association, regulation AIP1(INDUCES) 12589829 3 0 0 +SOX10 SOX10 Cell development/differentiation; DNA-binding; Transcription factor P56693 6663 22q13.1 human S45-p 456247 GGSGLRAsPGPGELG Sox_N protein stabilization 29315345 2 6 0 +Xbp1 XBP1 iso2 DNA-binding; Transcription factor O35426-2 22433 mouse S348-p 1876695603 SPFSDMSsPLGTDHS intracellular localization 34421344 1 0 0 increased S348 phosphorylation increases sumoylation and inhibits nuclear localization +Pard3 PAR3-alpha Adaptor/scaffold; Motility/polarity/chemotaxis Q9Z340 81918 19q12 rat S144-p 455668 PLHVRRSsDPALTGL molecular association, regulation 14-3-3 zeta(INDUCES) 33093242 4 21 26 +SLC6A4 SERT Membrane protein, integral; Membrane protein, multi-pass; Transporter P31645 6532 17q11.2 human T616-p 7576402 IKSITPEtPTEIPCG molecular association, regulation; intracellular localization Vimentin(DISRUPTS) 19270731 2 1 0 +MARK2 MARK2 iso13 EC 2.7.11.1; EC 2.7.11.26; KINASE; Kinase, protein; Protein kinase, CAMK; Protein kinase, Ser/Thr (non-receptor) Q7KZI7-13 2011 11q13.1 human T324-p 4145507 RYNEVMAtYLLLGYK UBA intracellular localization cytoskeletal reorganization; cell growth, altered 18760999 1 0 0 +NOS3 eNOS Amino Acid Metabolism - arginine and proline; EC 1.14.13.39; Oxidoreductase P29473 287024 cow S116-p 448638 RKLQTRPsPGPPPAE molecular association, regulation; enzymatic activity, inhibited; phosphorylation Src(DISRUPTS); Akt1(DISRUPTS) 12050171; 12591925; 23727078 22 4 0 eNOS S115A mutation increases phosphorylation of S1178 by about 50%; dephosphorylation of this site facilitates phosphorylation of Y83 +UBE2R2 UBC3B EC 6.3.2.19; Ligase; UBIQUITIN LIGASE; Ubiquitin conjugating system; Ubiquitin ligase Q712K3 54926 9p13.3 human S233-p 449751 DCYDDDDsGNEES__ molecular association, regulation transcription, altered BRD8 iso2(INDUCES) 12037680 1 1 0 CK2-dependent phosphorylation of UCB3C leads to beta-catenin degredation and inhibition of beta-catenin transcription. +MYBPC3 MYBPC3 Myosin-binding Q14896 4607 11p11.2 human S304-p 471081 SLLKKRDsFRTPRDS cytoskeletal reorganization 20018870 28 6 0 regulation of cardiac myofilament function +RAB7A Rab7 G protein; G protein, monomeric; G protein, monomeric, Rab P51149 7879 3q21.3 human K175-sm 1881818301 TIARNALkQETEVEL protein degradation; molecular association, regulation; enzymatic activity, induced PLEKHM1(DISRUPTS); RILP(DISRUPTS) 30510112 1 1 0 SUMOylation prevents bacterial multiplication and SCV stability, increases its GTPase activity +PIP5K1C PIP5K1C Carbohydrate Metabolism - inositol phosphate; EC 2.7.1.68; Kinase, lipid; Motility/polarity/chemotaxis O60331 23396 19p13.3 human S448-p 17550224 NTVFRKNsSLKSSPS molecular association, regulation; enzymatic activity, inhibited carcinogenesis, altered; cell motility, altered; cell adhesion, induced talin 1(DISRUPTS) 27775029; 30555634 2 1 0 Phosphorylation of PIP5K1C serve as an indicator of aggressiveness of breast tumors +Hsf1 HSF1 DNA-binding; Transcription factor P38532 15499 15 D3|15 35.95 cM mouse S303-p 449045 RVKQEPPsPPHSPRV Vert_HS_TF activity, inhibited transcription, inhibited; transcription, altered 11162511; 28724629 23 59 5 low but significant expression of Hsps under physiological growth conditions and after a mild stress +HLA-DRA HLA-DRA Membrane protein, integral P01903 3122 6p21.32 human K244-ub 6140801 FIIKGLRkSNAAERR intracellular localization 19117940 1 0 0 +ATM ATM DNA repair, damage; EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, Ser/Thr (non-receptor); Protein kinase, atypical; Tumor suppressor Q13315 472 11q22.3 human S1403-p 22496700 CHKTKLKsILEILSK enzymatic activity, induced cell cycle regulation 22099307 1 0 0 phosphorylation of S1403 is required for mitotic activation of ATM; required for the spindle checkpoint activation +MYLK smMLCK EC 2.7.11.18; KINASE; Kinase, protein; Protein kinase, CAMK; Protein kinase, Ser/Thr (non-receptor) P29294 100009143 rabbit S1011-p 468782 SSTGSPTsPLTAERL intracellular localization 12176732 5 22 2 +PHF2 PHF2 DEMETHYLASE; Demethylase; EC 1.14.11.-; Nucleolus O75151 5253 9q22.31 human S1056-p 11138771 FLTQRRPsASSPNNN molecular association, regulation transcription, induced Mrf-2(INDUCES) DNA(INDUCES) 21532585 1 12 7 demethylation of Mrf-2 K336, complex is then targeted to promoters and removes repressive H3K9m2 +CFTR CFTR Channel, chloride; EC 3.6.3.49; Hydrolase; Membrane protein, integral; Membrane protein, multi-pass; Transporter; Transporter, ABC family P13569 1080 7q31.2 human S511-p 477193 ENIIFGVsYDEYRYR ABC_tran activity, induced 17289674 2 0 0 regulates CFTR channel gating +LATS2 LATS2 EC 2.7.11.1; KINASE; Kinase, protein; Nuclear receptor co-regulator; Protein kinase, AGC; Protein kinase, Ser/Thr (non-receptor); Tumor suppressor Q9NRM7 26524 13q12.11 human S408-p 17600400 PVPSRTNsFNSHQPR activity, induced cell cycle regulation; apoptosis, inhibited; signaling pathway regulation 21118956; 30800215 2 5 0 Hippo pathway; in SAS cell line +GPKOW GPKOW RNA-binding Q92917 27238 Xp11.23 human T316-p 21127301 GTASSRKtLWNQELY molecular association, regulation RNA(DISRUPTS) 21880142 1 0 0 regulates pre-mRNA processing +DRD1 DRD1 GPCR, family 1; Membrane protein, integral; Membrane protein, multi-pass; Receptor, GPCR P21728 1812 5q35.2 human T428-p 458339 SVILDYDtDVSLEKI molecular association, regulation signaling pathway regulation G-alpha(s)(INDUCES); ARR3(INDUCES) 32503917 2 0 0 ERK1/2 activation +SNX18 SNX18 Motility/polarity/chemotaxis; Vesicle Q96RF0 112574 5q11.2 human S233-p 7322488 SRNLNRFsTFVKSGG autophagy, inhibited 23878278 1 3 0 +SULT4A1 SULT4A1 EC 2.8.2.-; Transferase Q9BR01 25830 22q13.31 human T11-p 2048305 SEAETPStPGEFESK protein degradation; molecular association, regulation PIN1(INDUCES) 19439498; 20920535 2 4 0 +Lrp1 LRP1 Cell surface; Membrane protein, integral; Motility/polarity/chemotaxis; Receptor, misc. Q91ZX7 16971 10|10 D3 mouse Y4474-p 473712 VEIGNPTyKMYEGGE activity, induced; molecular association, regulation RAB8A(INDUCES) 30208326 4 3 2 +PJA2 PJA2 EC 6.3.2.-; EC 6.3.2.19; Ligase; UBIQUITIN LIGASE; Ubiquitin conjugating system; Ubiquitin ligase O43164 9867 5q21.3 human T389-p 18713701 RVITQREtENNQMTS ubiquitination; enzymatic activity, induced signaling pathway regulation 21423175 1 0 0 S342A/T389A mutant fails to ubiquitylate PKAR2A in vitro +STX17 STX17 Membrane protein, integral; Membrane protein, multi-pass; Vesicle P56962 55014 9q31.1 human S202-p 102898200 SQQEKIDsIADHVNS SNARE intracellular localization autophagy, induced ATG101(INDUCES); RB1CC1(INDUCES) 30827897 1 1 0 assembly of ULK1-ATG13-FIP200 complexes; Localizes to the Golgi; colocalization and association with LC3 +Pag1 PAG Adaptor/scaffold; Membrane protein, integral Q9JM80 64019 2q23 rat Y165-p 454745 GPGVEGPyEVLKDSS PAG cell growth, altered 18498747 1 23 136 +GLI1 GLI1 C2H2-type zinc finger protein; Oncoprotein; Transcription factor P08151 2735 12q13.3 human S243-p 27708601 DCRWDGCsQEFDSQE molecular association, regulation; intracellular localization cell growth, induced; transcription, induced; transcription, inhibited SUFU(INDUCES) DNA(INDUCES); DNA(DISRUPTS) 23446420; 29662197 2 0 0 localized in cytoplasm +G6PD G6PD Carbohydrate Metabolism - pentose phosphate pathway; Cell development/differentiation; EC 1.1.1.49; Other Amino Acids Metabolism - glutathione; Oxidoreductase P11413 2539 Xq28 human Y428-p 7705803 DLTYGNRyKNVKLPD G6PD_C cell motility, altered 19359662 2 1 0 modulates Akt activity +KRT8 K8 Cytoskeletal P05787 3856 12q13.13 human K101-ac 461563 QIKTLNNkFASFIDK Filament cytoskeletal reorganization 18203277 1 4 43 intermediate filament stabilization +KLF1 KLF1 C2H2-type zinc finger protein; DNA-binding; Transcription factor Q13351 10661 19p13.13 human K265-ac 460629 IAETAPSkRGRRSWA activity, induced transcription, induced 9707565 1 0 0 +CYLD CYLD DEUBIQUITINASE; EC 3.4.19.12; Protease; Tumor suppressor; Ubiquitin conjugating system; Ubiquitin-specific protease Q9NQC7 1540 16q12.1 human S436-p 12173907 TNGSIGHsPLSLSAQ CYLD_phos_site ubiquitination 15870263 1 0 0 induces ubiquitination of TRAF2 +LAT LAT iso2 Adaptor/scaffold; Membrane protein, integral O43561-2 27040 16p11.2 human Y171-p 448004 SMESIDDyVNVPESG LAT activity, induced; molecular association, regulation; phosphorylation cell differentiation, altered; cell motility, induced; cell growth, inhibited; cell adhesion, altered; signaling pathway regulation; transcription, altered GRB2(INDUCES); PLCG1(INDUCES); GADS(INDUCES); THEMIS(INDUCES); TSAd(INDUCES) 11395491; 12496416; 15029250; 15100278; 23460737; 27896837; 28699640; 30510001; 34161759; 35124007 24 1 17 induces Erk and calcium signaling; reduces contact times between T cells and dendritic cells +IRF3 IRF3 DNA-binding; Transcription factor Q14653 3661 19q13.33 human K105-ub 1877340003 KDPHDPHkIYEFVNS IRF transcription, induced DNA(INDUCES) 32075857 1 0 0 +FFAR1 FFAR1 GPCR, family 1; Membrane protein, integral; Membrane protein, multi-pass; Receptor, GPCR O14842 2864 19q13.12 human S298-p 25292282 ARTQGGKsQK_____ receptor internalization, induced; intracellular localization; phosphorylation signaling pathway regulation 35065200 1 1 1 induces ERK phosphorylation, induces FFA1 receptor signaling +TTK TTK Cancer Testis Antigen (CTA); EC 2.7.12.1; KINASE; Kinase, protein; Protein kinase, Other; Protein kinase, dual-specificity (non-receptor) P33981 7272 6q14.1 human T453-p 471487 DPKSICKtPSSNTLD protein stabilization; molecular association, regulation CDKN3(INDUCES) 26586430 2 4 9 recruiting Cdkn3 to centrosomes, interaction is required for maintaining the proper number of centrosomes +TNK2 Ack EC 2.7.10.2; EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, TK; Protein kinase, tyrosine (non-receptor) Q07912 10188 3q29 human Y284-p 450946 LPQNDDHyVMQEHRK PK_Tyr_Ser-Thr phosphorylation; enzymatic activity, induced cell cycle regulation; cell growth, induced; apoptosis, inhibited; transcription, induced 16472662; 25148682; 37330596 14 28 235 +Irs1 IRS1 Adaptor/scaffold; Motility/polarity/chemotaxis P35569 16367 1 C5|1 42.0 cM mouse S302-p 450190 TRRSRTEsITATSPA phosphorylation neural plasticity; signaling pathway regulation; cell growth, altered 14623899; 20332342; 32075735 56 12 1 +Syngap1 SynGAP GAP; GAP, Ras F6SEU4 240057 17|17 A3.3 mouse S817-p 33636339 RPPLARSsPAYCTSS DUF3498 activity, induced 25533468 1 1 2 S817D mutation increases Rap2 GAP , rap1 GAP and HRas GAP activities of SynGAP +PFN1 profilin 1 Actin-binding; Cytoskeletal; Motility/polarity/chemotaxis P07737 5216 17p13.2 human Y129-p 450514 GLINKKCyEMASHLR Profilin protein stabilization; molecular association, regulation carcinogenesis, induced; cell growth, induced; transcription, induced VHL(INDUCES) 24747440 4 25 658 prevents degradation of HIF-1a +TOP1 TOP1 EC 5.99.1.2; Isomerase; Nucleolus; Oncoprotein P11387 7150 20q12 human K117-sm 2793907 FSSPPQIkDEPEDDG molecular association, regulation; intracellular localization apoptosis, induced DNA(INDUCES) 12149243; 12439742 4 5 0 increase in CPT-induced apoptosis; enhances TOPO1-DNA cleavable complex formation induced by CPT +Myl12b MRLC2 Contractile Q3THE2 67938 17|17 E1.3 mouse S2-p 448593 ______MsSKKAKTK cytoskeletal reorganization; cell adhesion, altered 17928407 1 0 0 induced disassembly of stress fibers and decreased large focal adhesions +SLK SLK EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, STE; Protein kinase, Ser/Thr (non-receptor) Q9H2G2 9748 10q24.33-q25.1 human T183-p 1211366 VSAKNTRtIQRRDSF Pkinase molecular association, regulation; phosphorylation; enzymatic activity, induced apoptosis, induced SLK(INDUCES) 22203681; 28475647 2 13 27 induces phosphorylation of JNK and p38, homodimerization induces kinase activity +Mapk3 ERK1 EC 2.7.11.24; KINASE; Kinase, protein; Protein kinase, CMGC; Protein kinase, Ser/Thr (non-receptor) Q63844 26417 7 F3|7 69.25 cM mouse T203-p 447542 HDHTGFLtEYVATRW Pkinase intracellular localization; enzymatic activity, induced cell cycle regulation; carcinogenesis, induced; carcinogenesis, inhibited; apoptosis, induced; cell motility, induced; cell growth, inhibited; cell motility, inhibited; transcription, induced; signaling pathway regulation; transcription, altered; neural plasticity; cell growth, induced; apoptosis, inhibited; cytoskeletal reorganization; transcription, inhibited 10867029; 11934884; 12446705; 1518847; 15788406; 15975986; 19004831; 21562256; 21706057; 21813649; 21887248; 21917714; 25584415; 34118691; 34191798; 34520454; 34617326; 35085550; 35857631; 36070687; 36088505; 36310322; 36736425; 37160873; 37430253 1343 110 2017 +Nfat5 NFAT5 Transcription factor Q9WV30 54446 8 D3|8 53.93 cM mouse Y143-p 12127405 PKRHTVLyISPPPED molecular association, regulation transcription, inhibited TAZ(INDUCES) 23045390 5 1 0 Y316 TAZ negatively regulates SL6A12 and SLC5A3 gene expression; luciferase reporter +SEPTIN9 SEPT9 Cell cycle regulation; Cytoskeletal; Hydrolase Q9UHD8 10801 17q25.3 human S30-p 453398 SGPALKRsFEVEEVE apoptosis, induced; cell adhesion, induced 25944883 1 73 26 +KHDRBS1 KHDRBS1 RNA-binding Q07666 10657 1p35.2 human R310-m1 476771 GRGVGPPrGALVRGT intracellular localization 12529443 1 4 19 +EEF2 EEF2 Translation; Translation elongation P55823 rabbit T56-p 448040 RAGETRFtDTRKDEQ GTP_EFTU activity, inhibited 8386634 39 61 54 +MAVS MAVS Adaptor/scaffold; Membrane protein, integral Q7Z434 57506 20p13 human K10-ub 89115600 FAEDKTYkYICRNFS CARD_2 molecular association, regulation MAVS(INDUCES) 27992402 1 0 0 +FERMT1 kindlin-1 Cytoskeletal; Motility/polarity/chemotaxis Q9BQL6 55612 20p12.3 human S179-p 2508995 TASGSSVsPGLYSKT protein degradation cell cycle regulation; cell growth, induced; apoptosis, inhibited; cytoskeletal reorganization; cell adhesion, inhibited 35469017 1 6 0 +Sf1 SF1 RNA splicing; RNA-binding; Spliceosome; Transcription, coactivator/corepressor NP_001104263 117855 1q43 rat S20-p 449919 PSKKRKRsRWNQDTM SF1-HH molecular association, regulation RNA splicing, altered U2AF2(DISRUPTS) 10449420 2 3 0 +Fmr1 FMR1 Nucleolus; RNA-binding; Translation P35922 14265 X A7.1|X 34.83 cM mouse R538-me 4046003 RRRRGGGrGQGGRGR FXMRP1_C_core molecular association, regulation RNA(DISRUPTS) 20064924 2 0 0 methylation inhibits sc1 RNA binding; R533 and R538 determine association with polyribosomes; methylation doesnot inhibit AATYK mRNA association; different RNAs have distinct molecular requirements for binding to FMR1 +Grin1 NMDAR1 Channel, calcium; Channel, ligand-gated; Membrane protein, integral; Membrane protein, multi-pass P35439 24408 3p13 rat S897-p 448256 SFKRRRSsKDTSTGG receptor desensitization, inhibited; molecular association, regulation; receptor inactivation, inhibited Calmodulin(DISRUPTS) 24847051; 9252405 27 0 0 +Ulk1 ULK1 Autophagy; EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, Other; Protein kinase, Ser/Thr (non-receptor) O70405 22241 5|5 F mouse S467-p 483136 SAIRRSGsTTPLGFG autophagy, altered 21205641 3 21 4 +ROCK1 ROCK1 EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, AGC; Protein kinase, Ser/Thr (non-receptor) Q13464 6093 18q11.1 human T1337-p 18261228 RTLSTRStANQSFRK intracellular localization cytoskeletal reorganization 21685893 1 3 2 inhibits apical constriction +ADRA1D ADRA1D GPCR, family 1; Membrane protein, integral; Membrane protein, multi-pass; Receptor, GPCR P25100 146 20p13 human S332-p 1424270006 KGHTFRSsLSVRLLK 7tm_1 receptor internalization, altered signaling pathway regulation 29551601 1 1 0 regulates ERK signaling pathway, induces calcium signaling de-sensitization +TCF7L2 TCF7L2 Apoptosis; Cell cycle regulation; Cell development/differentiation; DNA-binding; Motility/polarity/chemotaxis; Transcription factor Q9NQB0 6934 10q25.2-q25.3 human S177-p 14918200 QALKDARsPSPAHIV CTNNB1_binding transcription, induced 20530691 1 9 0 +WWOX WWOX Apoptosis; EC 1.1.1.-; Oxidoreductase; Tumor suppressor Q9NZC7 51741 16q23.1-q23.2 human K274-ub 21188582 DINDSLGkLDFSRLS protein stabilization; molecular association, regulation cell cycle regulation; DNA repair, induced ATM(INDUCES) 26675548 1 3 0 G2/M phase checkpoint activation, maintains genomic stability +Lck Lck EC 2.7.10.2; KINASE; Kinase, protein; Oncoprotein; Protein kinase, TK; Protein kinase, tyrosine (non-receptor) P06240 16818 4 D2.2|4 63.26 cM mouse Y505-p 447823 FTATEGQyQPQP___ protein stabilization; intracellular localization; enzymatic activity, inhibited; phosphorylation cell differentiation, inhibited; cell cycle regulation; carcinogenesis, induced; apoptosis, altered; cell growth, inhibited; signaling pathway regulation 14749125; 15199125; 15699109; 17719247; 33420490; 33684096; 35638332; 36376335; 8413300 57 32 805 inhibits phosphorylation of PLCG1, LAT and ZAP70; inhibits phosphorylation of ZAP70, ERK, and translocation of NFATc2, inhibits ERK signaling +Kcnj12 KCNJ12 Membrane protein, integral; Membrane protein, multi-pass P52188 117052 10q22 rat S425-p 2150913 ERPYRREsEI_____ molecular association, regulation DLG1(DISRUPTS) 11181181 1 0 0 +Atoh1 ATOH1 Cell development/differentiation; DNA-binding; Transcription factor P48985 11921 6 C1|6 30.03 cM mouse S193-p 149314900 FNNDKKLsKYETLQM HLH cell motility, inhibited 28729444 1 0 0 193A mutant has a neuronal progenitor migration defect, motor coordination deficits and cerebellar foliation defects, mutant mice are deaf and lose inner ear hair cells +FH fumarase iso2 Carbohydrate Metabolism - citrate (TCA) cycle; EC 4.2.1.2; Lyase; Mitochondrial; Tumor suppressor P07954-2 2271 1q43 human S128-p 31878710 MLGGELGsKIPVHPN Lyase_1 intracellular localization; enzymatic activity, inhibited 33058874 1 2 0 +SIRT7 SIRT7 DEACETYLASE; Deacetylase; EC 3.5.1.-; Nucleolus Q9NRC8 51547 17q25.3 human T153-p 125108501 TLTHMSItRLHEQKL SIR2 activity, induced; protein degradation; molecular association, regulation; intracellular localization transcription, inhibited REG3G(INDUCES) 27511885; 28582407 2 0 0 inhibits rDNA transcription, saves energy to maintain cell survival +Rrad RRAD G protein; G protein, monomeric; G protein, monomeric, RGK NP_445790 83521 19p14 rat S272-p 457396 AGTRRREsLGKKAKR activity, induced 36215501 4 1 0 induces CaV1.2 activity +Rnf31 RNF31 EC 6.3.2.-; EC 6.3.2.19; Ligase; UBIQUITIN LIGASE; Ubiquitin conjugating system; Ubiquitin ligase Q924T7 268749 14|14 C3 mouse K1050-ub 21183662 YQARLLQkLREEVPL enzymatic activity, inhibited; protein conformation transcription, inhibited 26578682 1 5 0 negatively regulates NF-kB activation induced by bacterial LPS-mediated TLR4 stimulation +PTPN11 SHP-2 iso1 EC 3.1.3.48; Motility/polarity/chemotaxis; PHOSPHATASE; Protein phosphatase, tyrosine (non-receptor) Q06124-1 5781 12q24.13 human Y546-p 448492 SKRKGHEyTNIKYSL molecular association, regulation; enzymatic activity, induced GAB2(INDUCES) 23980151 38 25 442 +Smarca2 SMARCA2 EC 3.6.1.-; EC 3.6.4.-; Helicase; Nuclear receptor co-regulator; Transcription, coactivator/corepressor Q6DIC0 67155 19 C1|19 21.17 cM mouse K1551-ac 460624 RPNRGKAkPVVSDFD molecular association, regulation; protein conformation cell growth, induced; transcription, inhibited Rb(DISRUPTS) DNA(DISRUPTS) 14657023 1 0 0 +SNAI2 Snail2 Apoptosis; C2H2-type zinc finger protein; Motility/polarity/chemotaxis; Transcription factor O43623 6591 8q11.21 human K166-ac 59171804 FSCKYCDkEYVSLGA zf-C2H2 protein stabilization cell motility, induced 32737855 2 2 0 promotes breast cancer cell EMT and migration +Rb1 Rb Nuclear receptor co-regulator; Oncoprotein; Transcription, coactivator/corepressor; Tumor suppressor P13405 19645 14 38.73 cM|14 D3 mouse S804-p 448717 IYISPLKsPYKISEG Rb_C molecular association, regulation; protein conformation; phosphorylation cell cycle regulation; carcinogenesis, induced; transcription, induced; transcription, altered; chromatin organization, altered; cell growth, induced; apoptosis, inhibited; DNA repair, inhibited; transcription, inhibited; cell growth, altered E2F1(DISRUPTS); SUV420H1(DISRUPTS); SUV420H2(DISRUPTS) 10207050; 1565466; 19217427; 32086342; 33826903; 35023164; 35947949; 9671466 96 40 80 transcriptional downregulation of the E2F-1, E2F-2, dihydrofolate reductase, thymidine kinase, c-myc, proliferating-cell nuclear antigen, p107, and p21/Cip1 genes +GCM1 GCM1 DNA-binding; Transcription factor Q9NP62 8521 6p12.1 human S322-p 7979600 NYPFPLTsWPCSFSP protein degradation; acetylation; molecular association, regulation; ubiquitination transcription, inhibited FBXW2(INDUCES) 19416964; 20855292 2 0 0 inhibits acetylation +GLI3 GLI3 C2H2-type zinc finger protein; Transcription factor P10071 2737 7p14.1 human K595-m1 56418601 SNASDRAkHQNRTHS zf-C2H2 molecular association, regulation cell growth, induced DNA(INDUCES) 27146893 1 1 0 positively regulates tumorigenesis in NSCLCs +Yy1 YY1 C2H2-type zinc finger protein; Cell development/differentiation; Transcription factor Q8CHJ4 24919 6q32 rat S117-p 460025 EVVGGDDsDGLRAED molecular association, regulation cell growth, induced; transcription, altered ZKSCAN4(INDUCES) DNA(INDUCES) 34747636 3 34 0 +RET Ret EC 2.7.10.1; KINASE; Kinase, protein; Membrane protein, integral; Oncoprotein; Protein kinase, TK; Protein kinase, tyrosine (receptor) P07949 5979 10q11.21 human Y1096-p 449891 RYPNDSVyANWMLSP molecular association, regulation GRB2(INDUCES); PIK3R1(INDUCES) 10995764; 15677445 7 2 3 +Pin1 PIN1 EC 5.2.1.8; Isomerase; Nuclear receptor co-regulator Q9QUR7 23988 9 A3|9 7.6 cM mouse S73-p 18710000 HSQSRRPsSWRQEKI Rotamase enzymatic activity, inhibited; phosphorylation 35002518 6 1 0 induces Tau hyperphosphorylation +Vangl2 VANGL2 Adaptor/scaffold; Membrane protein, integral; Membrane protein, multi-pass Q91ZD4 93840 1 H3|1 79.54 cM mouse S464-p 18507000 AKQWTLVsEEPVTNG Strabismus protein stabilization 21316586 1 0 0 +Slc24a4 SLC24A4 Membrane protein, integral; Membrane protein, multi-pass; Transporter; Transporter, SLC family Q8CGQ8 238384 12|12 E mouse T331-p 29674703 AGLRIMItNKFGPRT activity, induced 24224486 1 0 0 T312A reduced the stimulatory effect of ATP by 50%. +Arnt ARNT DNA-binding; Motility/polarity/chemotaxis; Transcription factor P53762 11863 3 F2.1|3 40.74 cM mouse K245-sm 2293714 DLKTGTVkKEGQQSS PAS molecular association, regulation transcription, inhibited PML(DISRUPTS) 12354770 1 0 0 +RAD51 RAD51 DNA repair, damage; Mitochondrial Q06609 5888 15q15.1 human T13-p 23305002 QLEANADtSVEEESF molecular association, regulation; intracellular localization DNA repair, induced NBS1(INDUCES); BRCA2(INDUCES) 22325354; 24835992 2 1 0 involved in DNA damage recognition and homologous recombination (HR) repair +RBL2 Rb-like 2 Transcription, coactivator/corepressor; Tumor suppressor Q08999 5934 16q12.2 human S662-p 449728 GLGRSITsPTTLYDR molecular association, regulation cell cycle regulation E2F4(DISRUPTS) 11157749; 12006580 3 14 3 +Ciz1 CIZ1 Cell cycle regulation Q8VEH2 68379 2|2 B mouse T192-p 22648005 ARTPSSTtPNRKDSS molecular association, regulation; activity, inhibited cell cycle regulation CCNA1(DISRUPTS) 15585571; 25736292 2 0 0 phosphorylation of T293 and T192, T144 are required for interaction with the cyclinA-CDK2 complex and directing it to chromatin; DNA replication +Mpl MPL Membrane protein, integral; Receptor, cytokine Q08351 17480 4 D2.1|4 54.61 cM mouse Y616-p 450267 THIANHSyLPLSYWQ activity, induced; phosphorylation cell differentiation, altered; transcription, altered; cell growth, altered SHC1(INDUCES) 10803464; 14726379; 19996410; 8978680 11 1 1 TPO induced differentiation requires C-terminal, Y616-p. +BLM BLM DNA repair, damage; DNA replication; EC 3.6.4.12; Helicase P54132 641 15q26.1 human T99-p 450958 NAPAGQEtQRGGSKS BLM_N molecular association, regulation cell cycle regulation; apoptosis, inhibited H2AX(INDUCES); PML(DISRUPTS); TOP3A(DISRUPTS) 12034743; 14729972; 16199871 6 0 0 In cells expressing BLM T99A/T122A after HU release, entrance into G1 phase was delayed, with p-Chk-1 levels remaining elevated. ; radiosensitivity +Gata1 GATA1 DNA-binding; Transcription factor P17679 14460 X A1.1|X 3.59 cM mouse K312-ac 459079 RNRKASGkGKKKRGS protein degradation; acetylation; ubiquitination; phosphorylation cell differentiation, induced DNA(INDUCES) 10207073; 16858405 6 1 0 +SHC4 SHC4 Adaptor/scaffold Q6S5L8 399694 15q21.1 human Y413-p 63044905 IQCEKLCyLPGNSKC molecular association, regulation SHP-2(INDUCES) 28213521 1 1 0 +YWHAZ 14-3-3 zeta Adaptor/scaffold; Motility/polarity/chemotaxis P63104 7534 8q22.3 human T232-p 449846 LTLWTSDtQGDEAEA molecular association, regulation; protein conformation; activity, inhibited 14-3-3 zeta(DISRUPTS); RAF1(DISRUPTS); Tau iso3(DISRUPTS); HSP20(DISRUPTS) 14613942; 15119949; 18559254; 21081103; 9360956 7 12 26 +Srebf1 SREBP-1 iso1 DNA-binding; Membrane protein, integral; Membrane protein, multi-pass; Transcription factor P56720-1 78968 10q22 rat S73-p 14580856 KVTPAPLsPPPSAPT protein degradation; molecular association, regulation; ubiquitination transcription, inhibited SCAP(DISRUPTS) 26589965 1 10 0 +KRT8 K8 Cytoskeletal P05787 3856 12q13.13 human S74-p 448539 TVNQSLLsPLVLEVD Keratin_2_head protein stabilization; molecular association, regulation; ubiquitination; intracellular localization carcinogenesis, inhibited; cell growth, inhibited; apoptosis, induced; cell motility, altered; cell motility, inhibited; cytoskeletal reorganization JNK1(INDUCES); P38A(INDUCES) 10623656; 11781324; 11788583; 15368451; 15707998; 15972820; 17535969; 18617517; 19115206; 19246484; 22114688; 31427430; 32365802 29 8 9 induces solubility of keratin filaments and inhibits polymerization +FANCD2 FANCD2 DNA repair, damage Q9BXW9 2177 3p25.3 human T596-p 460935 RSESPSLtQERANLS FancD2 activity, induced; molecular association, regulation; ubiquitination; intracellular localization signaling pathway regulation DNA(INDUCES) 37392383 2 3 9 regulates the FA pathway +FGFR1 FGFR1 EC 2.7.10.1; KINASE; Kinase, protein; Membrane protein, integral; Oncoprotein; Protein kinase, TK; Protein kinase, tyrosine (receptor) P11362 2260 8p11.23 human S777-p 2721300 SMPLDQYsPSFPDTR intracellular localization cell growth, inhibited; cell motility, inhibited 18411303; 23405013 4 1 0 in DRG neurons axon length was increased in neurons overexpresing the S777A mutant. +P2rx1 P2X1 Channel, ligand-gated; Membrane protein, integral; Membrane protein, multi-pass P51576 18436 11 B4|11 45.09 cM mouse S387-p 26392105 ERDPAATsSTLGLQE carcinogenesis, induced; cell growth, induced 36418376 2 1 0 +SOX9 SOX9 DNA-binding; Transcription factor P48436 6662 17q24.3 human S64-p 451039 EPDLKKEsEEDKFPV Sox_N molecular association, regulation; intracellular localization KPNB1(INDUCES) 15889150 6 0 0 +Prkaa1 AMPKA1 Autophagy; EC 2.7.11.1; EC 2.7.11.26; EC 2.7.11.27; EC 2.7.11.31; KINASE; Kinase, protein; Protein kinase, CAMK; Protein kinase, Ser/Thr (non-receptor) P54645 65248 2q16 rat S496-p 450431 ATPQRSGsISNYRSC AdenylateSensor activity, induced; enzymatic activity, inhibited cell cycle regulation; transcription, induced; signaling pathway regulation 16340011; 17023420; 17032173; 35863470 19 46 55 regulates the AMPK-SIRT3 pathway +PML PML Nucleolus; Oncoprotein; SUMO LIGASE; SUMO conjugating system; SUMO ligase; Transcription factor; Tumor suppressor; Ubiquitin conjugating system P29590 5371 15q24.1 human K487-sm 2793912 SQTQCPRkVIKMESE DUF3583 intracellular localization transcription, induced 23542129; 9885291 2 0 0 +Tfeb TFEB DNA-binding; Transcription factor Q9R210 21425 17 C|17 23.99 cM mouse S462-p 4785132 PEASKASsRRSSFSM DUF3371 protein stabilization; intracellular localization autophagy, induced; transcription, induced 23599343; 35686465 2 3 0 +SHMT1 SHMT1 Amino Acid Metabolism - glycine, serine and threonine; Cofactor and Vitamin Metabolism - one carbon pool by folate; EC 2.1.2.1; Energy Metabolism - methane; Lyase; METHYLTRANSFERASE; Methyltransferase; Mitochondrial; Other Amino Acids Metabolism - cyanoamino acid P34896 6470 17p11.2 human K39-sm 12004407 EVYNIIKkESNRQRV SHMT intracellular localization 17446168 1 0 0 +Dyrk1a DYRK1A EC 2.7.12.2; KINASE; Kinase, protein; Protein kinase, CMGC; Protein kinase, dual-specificity (non-receptor) Q61214 13548 16 C4|16 55.3 cM mouse Y147-p 463250 YDDDNYDyIVKNGEK intracellular localization cell cycle regulation; cell differentiation, altered 21878370 1 2 18 +Il6st gp130 Membrane protein, integral; Receptor, cytokine Q00560 16195 13 D2.2|13 63.73 cM mouse Y757-p 448181 STASTVQySTVVHSG activity, induced; molecular association, regulation; phosphorylation signaling pathway regulation; transcription, altered SOCS3(INDUCES); SHP-2(INDUCES) 12070777; 12593670; 36947594 14 1 2 protection from bacterial infection, promotes increases in IFN-gamma levels; SHP-2 phosphorylation; regulates Src and MAPK/ERK signaling +Mapt Tau ACETYLTRANSFERASE; Acetyltransferase; Cytoskeletal P19332 29477 10q32.1 rat S727-p 454127 SNVSSTGsIDMVDSP neural plasticity 33768378; 33797746 8 13 0 +FERMT1 kindlin-1 Cytoskeletal; Motility/polarity/chemotaxis Q9BQL6 55612 20p12.3 human S176-p 31869918 SSPTASGsSVSPGLY protein degradation cell cycle regulation; cell growth, induced; apoptosis, inhibited; cytoskeletal reorganization; cell adhesion, inhibited 35469017 1 2 0 +WRN WRN Cell cycle regulation; DNA repair, damage; DNA-binding; EC 3.6.4.12; Helicase; Nucleolus Q14191 7486 8p12 human K1117-ac 14512101 YSYKPCDkISSGSNI protein stabilization; ubiquitination 20428248 1 1 0 inhibits ubiquitination +Cysltr1 CYSLTR1 GPCR, family 1; Membrane protein, integral; Membrane protein, multi-pass; Receptor, GPCR Q99JA4 58861 X|X D mouse T151-p 27717317 VQNINLVtQKKARFV 7tm_1 receptor desensitization, induced 23485744 1 0 0 +KCND2 Kv4.2 Channel, potassium; Membrane protein, integral; Membrane protein, multi-pass Q9NZV8 3751 7q31.31 human K579-sm 1879723001 SRSSLNAkMEECVKL endocytosis, inhibited 34795560 2 0 0 ~37?70% increase in channel surface expression and IA Gmax, 65 %reduction in ternary complexes internalization with KChIP2a and DPP10c +PROX1 PROX1 DNA-binding; Nuclear receptor co-regulator; Transcription factor Q92786 5629 1q32.3 human K556-sm 6124707 GLSLSLIkSECGDLQ molecular association, regulation; intracellular localization cell growth, induced; transcription, induced HDAC3(DISRUPTS) DNA(INDUCES) 18948102; 19706680 2 0 0 induces lymphangiogenesis; Sumoylation downregulates the corepressor activity of Prox1 and reduces its recruitment of HDAC3. +EGFR EGFR EC 2.7.10.1; KINASE; Kinase, protein; Membrane protein, integral; Oncoprotein; Protein kinase, TK; Protein kinase, tyrosine (receptor) P00533 1956 7p11.2 human T1041-p 3178896 LLSSLSAtSNNSTVA receptor internalization, induced; protein degradation 24797263 2 4 0 +CENPT CENPT DNA replication F1NPG5 chicken S88-p 27528600 IQNQPQVsPLALQTV CENP-T_N molecular association, regulation SPC25(INDUCES); SPBC24(INDUCES) 23334297 1 0 0 +INSIG1 INSIG1 Membrane protein, integral; Membrane protein, multi-pass O15503 3638 7q36.3 human K156-ub 486340 SHLGEPHkFKREWAS INSIG protein degradation 16399501; 16549805 2 0 0 INSIG1 is degraded more rapidly than INSIG2 which controlled by serine residues flanking the ubiquitination sites in both proteins. +Eif2b5 eIF2B-epsilon Translation; Translation initiation Q64350 192234 11q23 rat S535-p 449905 VDPEELDsRAGSPQL translation, altered; cytoskeletal reorganization; signaling pathway regulation; translation, inhibited; cell growth, altered 15001529; 22231169 10 3 0 +CREB1 CREB DNA-binding; Transcription factor P16220 1385 2q33.3 human S107-p 451811 SVDSVTDsQKRREIL pKID molecular association, regulation; activity, inhibited transcription, inhibited CBP(DISRUPTS) 15073328; 17209043 12 0 0 +JUN Jun Oncoprotein; Transcription factor P05412 3725 1p32.1 human T91-p 450448 SNGHITTtPTPTQFL Jun molecular association, regulation; activity, inhibited transcription, inhibited; transcription, altered MBD3(DISRUPTS); TCF4(DISRUPTS) DNA(DISRUPTS) 12853483; 36253406; 7744008 8 2 0 +STK4 MST1 Autophagy; EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, STE; Protein kinase, Ser/Thr (non-receptor) Q13043 6789 20q13.12 human K59-m2 63128907 TGQIVAIkQVPVESD Pkinase enzymatic activity, inhibited 28114269 1 1 0 +Tomm70a TOMM70A Membrane protein, integral; Mitochondrial; Receptor, protein translocating Q9CZW5 28185 16 C1.1|16 34.22 cM mouse S94-p 1983231 KTPEGRAsPALGSGH O-GlcNAc glycosylation; intracellular localization 33592173 1 89 2 inhibits MIC19 nuclear import +NFE2 NF-E2 Cytoskeletal; DNA-binding; Transcription factor Q16621 4778 12q13.13 human K137-ub 11489903 GLPAGPPkPQEDPES protein degradation; ubiquitination transcription, inhibited 19966288 1 0 0 +DNM1L DRP1 Apoptosis; EC 3.6.5.5; Endoplasmic reticulum; Hydrolase; Microtubule-binding; Mitochondrial; Motor O00429 10059 12p11.21 human K535-sm 9859921 VSRDKSSkVPSALAP activity, induced; intracellular localization 19638400 1 0 0 sumoylation is linked to its GTPase activity cycle, and influenced by DRP1 localization +Kcnb1 Kv2.1 Channel, cation; Channel, ligand-gated; Channel, potassium; Membrane protein, integral; Membrane protein, multi-pass Q03717 16500 2 H3|2 87.22 cM mouse Y690-p 22874701 LLPALGLyHDPLRNR apoptosis, induced 33333928 2 2 2 +GPBAR1 GPBAR1 GPCR, family 1; Membrane protein, integral; Membrane protein, multi-pass; Receptor, GPCR Q8TDU6 151306 2q35 human S323-p 1877729204 AYHPSSQsSVDLDLN molecular association, regulation cell growth, induced; apoptosis, inhibited ARRB1(INDUCES) 35858343 0 1 0 +PRMT1 PRMT1 EC 2.1.1.125; METHYLTRANSFERASE; Methyltransferase; Methyltransferase, protein arginine; Nuclear receptor co-regulator Q99873 3276 19q13.33 human Y309-p 454762 STSPESPyTHWKQTV molecular association, regulation; intracellular localization; enzymatic activity, induced carcinogenesis, induced; cell growth, induced; signaling pathway regulation hnRNP A3(DISRUPTS); hnRNP A1(DISRUPTS) 24358983; 36995937 2 15 126 induces mTOR signaling +TP53 p53 Activator; DNA-binding; Motility/polarity/chemotaxis; Nuclear receptor co-regulator; Transcription factor; Tumor suppressor P04637 7157 17p13.1 human K373-m2 13906423 SSHLKSKkGQSTSRH carcinogenesis, induced; apoptosis, inhibited 20118233 1 0 0 +Mlxipl ChREBP Transcription factor Q99MZ3 58805 5|5 G2 mouse S839-gl 89115102 RQLSTSTsILTDPSL molecular association, regulation; intracellular localization; protein conformation transcription, induced DNA(INDUCES) 28450420 1 0 0 assist translocation of ChREBP from nucleus to cytoplasm +MDM2 MDM2 EC 6.3.2.-; EC 6.3.2.19; Inhibitor; Ligase; NEDDYLATION LIGASE; Neddylation Ligase; Nucleolus; Oncoprotein; UBIQUITIN LIGASE; Ubiquitin conjugating system; Ubiquitin ligase Q00987 4193 12q15 human S425-p 11956708 ETQDKEEsVESSLPL molecular association, regulation; enzymatic activity, inhibited; protein conformation p53(DISRUPTS) 21986495 1 2 0 oligomerization inhibited +GOLGA2 GM130 Cytoskeletal Q08379 2801 9q34.11 human S37-p 454438 REYQQRNsPGVPTGA molecular association, regulation KPNA1(INDUCES); TAP(DISRUPTS) 26165940; 9753325 4 18 1 +NUP62 NUP62 Adaptor/scaffold; Nucleoporin P37198 23636 19q13.33 human S272-p 36440511 SGTSTTTsTAATATA protein degradation; phosphorylation signaling pathway regulation 30401435 1 0 0 induces phosphorylation of IRS1, regulates p38?/p62/mTORC1 pathway +CDK11A CDK11A iso10 Cell cycle regulation; EC 2.7.11.22; KINASE; Kinase, protein; Motility/polarity/chemotaxis; Protein kinase, CMGC; Protein kinase, Ser/Thr (non-receptor); RNA processing Q9UQ88-10 728642 1p36.33 human T370-p 35521302 KHEYFREtPLPIDPS enzymatic activity, induced carcinogenesis, inhibited; cell adhesion, altered; transcription, inhibited; signaling pathway regulation 25106495; 26470709 2 1 0 inhibited the VEGF promoter activity, inhibits angiogenesis; breast cancer metastasis inhibited, integrin B3 promoter activity inhibited, ERalpha protein levels repressed; inhibiting the invasion of breast cancer cells +MYC Myc DNA-binding; Nucleolus; Oncoprotein; Transcription factor P01106 4609 8q24.21 human T73-p 448496 KKFELLPtPPLSPSR Myc_N protein degradation; protein stabilization; molecular association, regulation; ubiquitination; intracellular localization; protein conformation; phosphorylation cell cycle regulation; carcinogenesis, induced; carcinogenesis, inhibited; cell growth, inhibited; apoptosis, induced; transcription, induced; transcription, altered; cell differentiation, altered; autophagy, induced; cell growth, induced; DNA repair, inhibited; transcription, inhibited; cell growth, altered FBXW7(INDUCES); SH2BP1(INDUCES); OTUD6A(INDUCES); CDC73(INDUCES); AurA(INDUCES); PIN1(INDUCES); TUBA4A(DISRUPTS); FBXW7(DISRUPTS) DNA(DISRUPTS) 10706881; 10713166; 10866684; 11018017; 11877389; 11904304; 14563837; 15103331; 15150404; 15673569; 16452238; 17634226; 18408012; 19028839; 19131971; 21441954; 21808024; 22025562; 23318434; 23716601; 24030976; 24998853; 25944903; 26687678; 27213815; 27239040; 27795300; 33461590; 33520979; 33541412; 33627622; 34504649; 35089787; 35217790; 35619182; 36012403; 36718632; 36719686; 37400551; 37495110; 37656618; 8386367 83 40 30 +SRF SRF Motility/polarity/chemotaxis; Transcription factor P11831 6722 6p21.1 human S103-p 447692 RGLKRSLsEMEIGMV molecular association, regulation transcription, altered DNA(INDUCES) 11859076; 1547771; 23548149; 8413226 14 3 5 +CDC37 CDC37 Chaperone Q16543 11140 19p13.2 human S13-p 450034 VWDHIEVsDDEDETH CDC37_N molecular association, regulation HSP90A(INDUCES); HRI(INDUCES) 12930845; 27105117 13 29 0 S13 phosphorylation does not impact recognition or affnity for BRAF. S13 affects chaperone cycle at a stage later than Cdc37 recognition. +Rasgrf1 RASGRF1 GEF; GEF, Ras P28818 192213 8q31 rat S760-p 18710206 LASLGCPsDGYTNIH protein degradation 21382555 1 1 0 +SRF SRF Motility/polarity/chemotaxis; Transcription factor P11831 6722 6p21.1 human K147-sm 2303901 TRGRVKIkMEFIDNK transcription, inhibited 12788062 1 0 0 +PGK1 PGK1 Carbohydrate Metabolism - glycolysis and gluconeogenesis; EC 2.7.2.3; KINASE; Kinase, other P00558 5230 Xq21.1 human S256-p 23131090 NNMEIGTsLFDEEGA PGK molecular association, regulation carcinogenesis, induced; cell growth, induced CDC7(INDUCES) 30392930 1 0 3 +RCOR1 RCOR1 Nuclear receptor co-regulator; Transcription, coactivator/corepressor Q9UKL0 23186 14q32.31-q32.32 human K297-sm 4645800 TETVPQVkKEKHSTQ transcription, inhibited 18854179 1 1 0 +Bad BAD Apoptosis Q61337 12015 19|19 A mouse S112-p 447860 ETRSRHSsYPAGTEE Bcl-2_BAD activity, induced; molecular association, regulation; intracellular localization apoptosis, altered; apoptosis, inhibited Bcl-xL(NOT_REPORTED); JNK1(DISRUPTS); 14-3-3 epsilon(INDUCES); PKACA(INDUCES); 14-3-3 beta(NOT_REPORTED); 14-3-3 beta(INDUCES); PPP2CA(INDUCES); Bcl-2(DISRUPTS); PKCA(INDUCES); Bcl-xL(DISRUPTS) 10230394; 10521512; 10574959; 10611223; 10777478; 10837486; 10887134; 10996800; 11583580; 11717309; 11983683; 12897128; 12944463; 12954615; 14670836; 15123689; 15280015; 15849194; 16009721; 16103085; 19217411; 19915011; 22103330; 23332762; 8929531 129 22 172 +RAD17 RAD17 Cell cycle regulation O75943 5884 5q13.2 human S678-p 1184590201 IIIEDYEsDGT____ molecular association, regulation; phosphorylation RAD1(INDUCES) 29902452; 31353086 2 0 0 induces phosphorylation of other sites +RUNX3 AML2 DNA-binding; Transcription factor Q13761 864 1p36.11 human T173-p 55571501 YHRAIKVtVDGPREP Runt molecular association, regulation cell cycle regulation; transcription, induced DNA(DISRUPTS) 27217562 1 0 0 regulating mitotic entry +ESR1 ER-alpha DNA-binding; Nuclear receptor; Transcription factor P03372 2099 6q25.1-q25.2 human K303-ac 459012 LMIKRSKkNSLALSL activity, induced; activity, inhibited; phosphorylation cell growth, inhibited; transcription, inhibited; transcription, altered 11279135; 15604293; 18471979; 19887647 4 1 0 K302/303A mutants are more active then wt protein at low concentration of E2 ; inhibits phosphorylation at S305; makes K302 a poorer substrate for methylation; suppresses ligand sensitivity +AQP2 AQP2 Channel, misc.; Membrane protein, integral; Membrane protein, multi-pass; Transporter; Transporter, aquaporin family P41181 359 12q13.12 human S264-p 2238600 VELHSPQsLPRGTKA intracellular localization exocytosis, induced 22778181; 32529500 20 8 0 +PTH1R PTHR GPCR, family 2; Membrane protein, integral; Membrane protein, multi-pass; Receptor, GPCR Q03431 5745 3p21.31 human T387-p 801662704 NIVRVLAtKLRETNA 7tm_2 molecular association, regulation; ubiquitination ARRB1(INDUCES) 29444827 1 1 0 abrogation of phosphorylation at positions T387and T392 dramatically decreased PTHR ubiquitination +AKT1 Akt1 EC 2.7.11.1; KINASE; Kinase, protein; Oncoprotein; Protein kinase, AGC; Protein kinase, Ser/Thr (non-receptor) P31749 207 14q32.33 human T450-p 447857 TAQMITItPPDQDDS Pkinase_C protein stabilization; molecular association, regulation; enzymatic activity, inhibited; phosphorylation; enzymatic activity, induced; activity, induced; ubiquitination; protein conformation carcinogenesis, induced; cell motility, induced; apoptosis, induced; signaling pathway regulation; transcription, altered; cell differentiation, altered; translation, altered; cell growth, induced PIN1(INDUCES) 15065872; 16306447; 17446865; 19448664; 20186153; 21045808; 21577208; 33941854; 34385319; 35625759; 9690513 30 5 1 +SLC12A3 NCCT Membrane protein, integral; Membrane protein, multi-pass; Transporter; Transporter, SLC family P55017 6559 16q13 human S73-p 469631 TYEHYANsTQPGEPR AA_permease_N activity, induced; molecular association, regulation; protein conformation ADD3(DISRUPTS) 21164023; 36792826 15 2 1 +EEF2 EEF2 Translation; Translation elongation P13639 1938 19p13.3 human K322-sm 32005105 LIEKLDIkLDSEDKD GTP_EFTU phosphorylation 24648518 1 0 0 induces tyrosine phosphorylation of itself +EEF2 EEF2 Translation; Translation elongation P13639 1938 19p13.3 human S595-p 27620701 NVLCLSKsPNKHNRL ADP-ribosylation; activity, induced; protein conformation; phosphorylation cell cycle regulation 23184662; 30218597 2 2 0 EEF2-T56 phosphorylation; phosphorylation of this site interferes with toxin-mediated ADP-ribosylation of EEF2 at H175 +Ppp1r1a PPP1R1A Inhibitor; Protein phosphatase, regulatory subunit Q9ERT9 58200 15|15 F3 mouse T35-p 447759 QIRRRRPtPATLVLT DARPP-32 molecular association, regulation PPA1(DISRUPTS) 24244723 14 4 0 +Notch1 Notch 1 Membrane protein, integral; Motility/polarity/chemotaxis; Oncoprotein; Receptor, misc.; Transcription factor Q01705 18128 2 A3|2 18.91 cM mouse R2361-m2 409457000 YQGLPNTrLATQPHL activity, induced; protein degradation; ubiquitination transcription, induced 25805888 1 1 0 +Bmp2k BIKE EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, Other; Protein kinase, Ser/Thr (non-receptor) Q91Z96 140780 5|5 E3 mouse S1010-p 467549 KKVGRRDsQSSNEFL BMP2K_C intracellular localization 36739695 1 35 0 +POLH POLH DNA repair, damage; EC 2.7.7.7; Transferase Q9Y253 5429 6p21.1 human K619-sm 1877365914 SVLEVTQkATPNPSL intracellular localization; enzymatic activity, inhibited 32350109 1 1 0 +HPSE HPSE EC 3.2.1.166; Extracellular matrix; Glycan Metabolism - glycosaminoglycan degradation; Hydrolase; Secreted; Secreted, signal peptide Q9Y251 10855 4q21.23 human Y156-p 3785036 QLLLREHyQKKFKNS Glyco_hydro_79n enzymatic activity, induced 21831044 1 0 0 regulates neuritogenesis +Card11 CARD11 Adaptor/scaffold Q8CIS0 108723 5|5 G2 mouse S620-p 5403700 RYSFGPPsIHSSSSS activity, inhibited 19917688 3 0 0 +Raf1 RAF1 EC 2.7.11.1; KINASE; Kinase, protein; Oncoprotein; Protein kinase, Ser/Thr (non-receptor); Protein kinase, TKL Q99N57 110157 6 E3|6 53.62 cM mouse Y340-p 447749 RGQRDSSyYWEIEAS phosphorylation; enzymatic activity, induced apoptosis, altered 11296227; 17535812 29 1 1 Bad Ser 112 + 136 phosphorylation +Adrb2 ADRB2 GPCR, family 1; Membrane protein, integral; Membrane protein, multi-pass; Receptor, GPCR P18762 11555 18 E1|18 35.1 cM mouse S355-p 458916 KTYGNGYsSNSNGRT receptor internalization, induced; receptor internalization, altered cell motility, induced; signaling pathway regulation 18056263; 25460042; 27541735; 31088898 27 2 0 IRS2 is required for ADRB2 internalization; B-arrestin mediated signaling; internalization and the contraction response +MYB Myb DNA-binding; Oncoprotein; Transcription factor P10242 4602 6q23.3 human K471-ac 458941 PRTPTPFkHALAAQE Cmyb_C molecular association, regulation transcription, induced DNA(INDUCES) 10656693 1 4 1 +LMNB1 Lamin B1 Cytoskeletal P20700 4001 5q23.2 human S395-p 448732 LKLSPSPsSRVTVSR cell cycle regulation 8663071 3 11 1 +SOD2 SOD2 EC 1.15.1.1; Mitochondrial; Oxidoreductase P04179 6648 6q25.3 human K68-ac 461133 NLNVTEEkYQEALAK Sod_Fe_N protein stabilization; intracellular localization; enzymatic activity, inhibited; activity, inhibited; protein conformation; enzymatic activity, altered cell differentiation, inhibited; cell cycle regulation; carcinogenesis, induced; cell growth, induced; cell differentiation, induced; transcription, induced 21566644; 25908444; 27540894; 27721400; 28369333; 28584055; 28687409; 31160585; 31189433; 31591207; 33680286; 33867840 23 13 8 dysregulated mitochondrial structure and localization, acetylation mimetic disrupts mitochondrial ultrastructure and metabolism. +UBXN2B UBXN2B Adaptor/scaffold; Endoplasmic reticulum Q14CS0 137886 8q12.1 human S56-p 3217941 PKATVFKsPRTPPQR molecular association, regulation; intracellular localization 20875789 1 6 4 important for Golgi disassembly at mitosis; inhibits p37 binding to Golgi membranes +H3F3C H3 DNA-binding P84229 427887 chicken K4-m2 459004 ____ARTkQTARKST Histone chromatin organization, altered; transcription, induced 17913747 108 10 0 +Nfatc2 NFAT1 DNA-binding; Transcription factor Q60591 18019 2 H3|2 88.91 cM mouse S177-p 447843 SPASSGSsASFISDT transcription, inhibited 11030334 0 1 0 +Rap1gap RAP1GAP iso2 GAP; GAP, Ras; Motility/polarity/chemotaxis A2ALS5-2 110351 4 D3|4 70.02 cM mouse S563-p 3190708 PFGSRRSsAIGIENI neural plasticity; signaling pathway regulation 33301817 4 25 25 A2aR-PKA-Rap1-MAPK signaling pathway +Nrip1 RIP140 Nuclear receptor co-regulator; Transcription, coactivator/corepressor Q8CBD1 268903 16|16 C3.1 mouse Y364-p 25234802 SSPKNTSyKNSLERN protein degradation; ubiquitination 22388040 1 0 0 regulates inflamatory responses and contributes to endotoxin tolerance +Was WASP Adaptor/scaffold; Motility/polarity/chemotaxis P70315 22376 X A1.1|X 3.65 cM mouse Y293-p 447985 AETSKLIyDFIEDQG PBD activity, induced; protein stabilization cell motility, altered; cytoskeletal reorganization; cell growth, altered 14707117; 19805221; 24223520 12 35 657 +MAP3K8 Cot EC 2.7.11.25; KINASE; Kinase, protein; Oncoprotein; Protein kinase, STE; Protein kinase, Ser/Thr (non-receptor) P41279 1326 10p11.23 human T290-p 455276 FPKDLRGtEIYMSPE Pkinase protein degradation; molecular association, regulation; phosphorylation; enzymatic activity, induced NFkB-p105(DISRUPTS) 15466476; 15699325; 16806191 6 0 0 required for phosphorylation of Cot Ser62 +Cebpb C/EBP-beta DNA-binding; Motility/polarity/chemotaxis; Transcription factor P28033 12608 2 H3|2 87.58 cM mouse S184-p 455886 LSTSSSSsPPGTPSP activity, induced; molecular association, regulation; protein conformation cell cycle regulation; cell differentiation, altered; cell differentiation, induced; transcription, induced; transcription, altered C/EBP-beta(INDUCES) DNA(INDUCES) 15985551; 17264204; 17601773; 19478079 8 9 9 +RBPJ RBPJ Cell development/differentiation; Transcription factor Q06330 3516 4p15.2 human K175-ub 41493905 SKKKQSLkNADLCIA LAG1-DNAbind chromatin organization, altered; transcription, induced 36129980 1 2 0 positively regulates Notch signaling +NACA NACA iso1 Motility/polarity/chemotaxis; Transcription, coactivator/corepressor Q13765 4666 12q13.3 human S151-p 4712206 KVQGEAVsNIQENTQ intracellular localization; activity, inhibited cell differentiation, inhibited; transcription, inhibited 30948508 1 5 0 +IGFBP1 IGFBP1 Secreted; Secreted, signal peptide P08833 3484 7p12.3 human S126-p 451658 GSPESPEsTEITEEE activity, induced; molecular association, regulation; activity, inhibited; phosphorylation signaling pathway regulation IGF1(INDUCES); CK2B(INDUCES) 18772238; 20143870; 23354097; 25957086; 32502935; 7683525 14 10 0 regulates mTOR and AAR signaling; inhibits IGF-1RB autophosphorylation and activity; S126A and S144A mutants inhibit IGF1R autophosphorylation +GAB1 GAB1 Adaptor/scaffold; Motility/polarity/chemotaxis Q13480 2549 4q31.21 human Y589-p 449792 SHDSEENyVPMNPNL molecular association, regulation SHP-2(INDUCES); PIK3R1(INDUCES) 10978177; 9658397 8 0 0 +RAD52 RAD52 DNA repair, damage P43351 5893 12p13.33 human K192-ac 971232905 EVDLTKAkRQDLEPS molecular association, regulation; intracellular localization DNA repair, induced RFA2(INDUCES); RPA3(INDUCES); RAD51(INDUCES); RPA1(INDUCES) 29590107 1 1 0 accumulation of RAD52 at DSB sites +Sox11 SOX11 DNA-binding; Transcription factor Q7M6Y2 20666 12|12 A2 mouse S30-p 56654271 EGEFMACsPVALDES intracellular localization transcription, induced 29973868 1 2 0 promotes nuclear vs. cytoplasmic localization but export to the cytoplasm may support the transcriptional inactivation of SOX11 +SMAD6 SMAD6 DNA-binding; Transcription factor O43541 4091 15q22.31 human K173-ub 31914118 LLLEQELkTVTYSLL MH1 molecular association, regulation; phosphorylation cell differentiation, induced; transcription, induced; signaling pathway regulation ALK2(DISRUPTS) 23455153 1 0 0 enhances Smad1 phosphorylation +GPLD1 GPLD1 EC 3.1.4.50; Glycan Metabolism - glycosylphosphatidylinositol (GPI)-anchor biosynthesis; Phospholipase; Secreted; Secreted, signal peptide P80109 287025 cow T309-p 457382 NGFHKNVtAALTKNI enzymatic activity, inhibited 10384965 1 0 0 +Map2 MAP2 iso3 Cytoskeletal; Motility/polarity/chemotaxis P15146-3 25595 9q32 rat K314-ac 62495503 LPDLKNVkSKIGSTD Tubulin-binding cytoskeletal reorganization 28002468 1 1 0 +Ppp2ca PPP2CA EC 3.1.3.16; Motility/polarity/chemotaxis; PHOSPHATASE; Protein phosphatase, Ser/Thr (non-receptor) P63331 24672 10q22 rat Y307-p 448571 VTRRTPDyFL_____ activity, induced; molecular association, regulation; enzymatic activity, inhibited; phosphorylation autophagy, inhibited; translation, induced PPP2CB(DISRUPTS) 17537547; 20542922; 22892311; 23796501; 25391447; 26378614 73 1 0 may contribute to SNCA accumulation +AKAP8 AKAP8 Adaptor/scaffold; Cell cycle regulation; Mitochondrial; RNA-binding O43823 10270 19p13.12 human Y539-p 40420000 IVKMLEKyLKGEDPF AKAP95 molecular association, regulation 25770215 1 0 0 Phenylalanine mutants inhibited dissociation from nuclear structures; structural chromatin changes +CASR CaR GPCR, family 3; Membrane protein, integral; Membrane protein, multi-pass; Motility/polarity/chemotaxis; Receptor, GPCR P41180 846 3q13.33-q21.1 human T888-p 449862 FKVAARAtLRRSNVS activity, induced; receptor desensitization, altered; activity, inhibited; phosphorylation signaling pathway regulation 12356761; 12409307; 15212956; 17376781; 21135065; 24336654; 31189667; 36818436; 9694886 10 1 0 regulates Ca2+ sensitivity +ACHE AChE EC 3.1.1.7; Hydrolase; Lipid Metabolism - glycerophospholipid; Membrane protein, GPI anchor P22303 43 7q22.1 human Y164-p 10799701 GASSLDVyDGRFLVQ COesterase enzymatic activity, induced 7836436 1 0 0 +MAP4K4 HGK EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, STE; Protein kinase, Ser/Thr (non-receptor) O95819 9448 2q11.2 human T191-p 7320315 RRNTFIGtPYWMAPE Pkinase activity, induced; enzymatic activity, inhibited; phosphorylation carcinogenesis, inhibited; cell growth, inhibited; cell adhesion, induced; signaling pathway regulation 12612079; 31792377 2 2 5 pLATS1 at T1079; mostly blocked invasive response; Hippo pathway +PRKCE PKCE EC 2.7.11.13; KINASE; Kinase, protein; Protein kinase, AGC; Protein kinase, Ser/Thr (non-receptor) Q02156 5581 2p21 human S346-p 2807904 SEEDRSKsAPTSPCD molecular association, regulation cell cycle regulation; transcription, altered 14-3-3 beta(INDUCES); 14-3-3 zeta(INDUCES) 18458086; 18604201; 34143863 3 11 0 +NCOA3 SRC-3 ACETYLTRANSFERASE; Acetyltransferase; EC 2.3.1.48; Motility/polarity/chemotaxis; Nuclear receptor co-regulator; Transcription, coactivator/corepressor Q9Y6Q9 8202 20q13.12 human K620-ac 460610 LESKGHKkLLQLLTC SRC-1 molecular association, regulation transcription, inhibited ER-alpha(DISRUPTS) 10490106 1 0 2 +H3c1 H3 DNA-binding P68433 360198 13|13 A3.1 mouse K27-m3 1308913 LATKAARkSAPATGG Histone molecular association, regulation; intracellular localization cell differentiation, inhibited; endocytosis, altered; transcription, altered; cell differentiation, altered; RNA splicing, altered; chromatin organization, altered; cell differentiation, induced; cell adhesion, altered; transcription, inhibited DNMT3A(INDUCES) DNA(INDUCES) 16717091; 17967893; 18039862; 19303854; 19434510; 19567879; 19915707; 20147304; 20395309; 20543957; 20574709; 20935159; 22237151; 23362347; 23375371; 24070375; 24162653; 26716510; 33195484; 33986537; 35035682; 35640597 195 24 3 JMJD3 inhibited H3K27me3 methylation levels which promoted BDNF transcription ; H2AK119ub1 was with other modications and worked with H3K27me3 to inhibit transcription.; axon guidance +ZBTB16 PLZF C2H2-type zinc finger protein; DNA-binding; Oncoprotein; Transcription, coactivator/corepressor Q05516 7704 11q23.2 human T282-p 2134716 RGKEGPGtPTRSSVI protein degradation cell cycle regulation; transcription, altered; cell growth, altered 18246121 1 3 4 +EAF2 EAF2 Transcription regulation Q96CJ1 55840 3q13.33 human K81-ub 55591502 TVFKGSKkPYLKECI EAF apoptosis, inhibited 27058417 1 0 0 +HINT1 HINT1 Cytoskeletal; EC 3.-.-.-; Hydrolase P49773 3094 5q23.3 human K21-ac 461229 GGDTIFGkIIRKEIP molecular association, regulation carcinogenesis, induced; cell growth, induced; transcription, induced CTNNB1(DISRUPTS); MITF(INDUCES) 28394346; 32636443 2 7 14 +SMN1 SMN RNA processing; RNA-binding Q16637 6606 5q13.2 human Y130-p 1025402 CVVVYTGyGNREEQN SMN molecular association, regulation; intracellular localization coilin(INDUCES) 24602413 1 2 0 +NEDD9 Cas-L Adaptor/scaffold; Motility/polarity/chemotaxis Q14511 4739 6p24.2 human T804-p 348338201 AALHYPStTALQEMV CAS_C molecular association, regulation; intracellular localization cell motility, induced PLK1(NOT_REPORTED) 29191835 1 1 0 localization of HEF1 to FAs +SIT1 SIT Adaptor/scaffold; Membrane protein, integral Q9Y3P8 27240 9p13.3 human Y169-p 448964 SGPEPELyASVCAQT activity, inhibited 11433379 1 2 146 SIT inhibition of T cell activation +ZNF622 ZNF622 Transcription factor Q969S3 90441 5p15.1 human S314-p 20765001 WCNEKGKsFYSTEAV zf-C2H2_2 phosphorylation apoptosis, induced; transcription, induced; signaling pathway regulation 21771788 1 0 0 increases phosphorylation of ASK1 substrates. Suppress PDK1 signaling +PML PML Nucleolus; Oncoprotein; SUMO LIGASE; SUMO conjugating system; SUMO ligase; Transcription factor; Tumor suppressor; Ubiquitin conjugating system P29590 5371 15q24.1 human K616-sm 56709103 PLVFFDLkIDNETQK molecular association, regulation PIAS1(INDUCES) 27099310 1 1 0 regulators of host immunity to virus infection of HSV1 +MAP3K7 TAK1 EC 2.7.11.25; KINASE; Kinase, protein; Protein kinase, Ser/Thr (non-receptor); Protein kinase, TKL O43318 6885 6q15 human T178-ac 1880881708 LKICDFGtACDIQTH phosphorylation signaling pathway regulation 36270986 1 1 0 induces TAK1-ADAM17 signaling; inhibits phosphorylation of itself at T184/T187 +Ola1 OLA1 EC 3.6.3.-; Hydrolase; Nucleolus Q9CZ30 67059 2|2 C3 mouse Y236-p 1880539204 VNLSEKDyIRKKNKW protein stabilization; molecular association, regulation; ubiquitination; intracellular localization IMPA1(INDUCES) 36481055 1 1 0 inhibits ubiquitination +SOX6 SOX6 DNA-binding P35712 55553 11p15.2 human K417-sm 2407405 TSPVTQVkDEAAAQP intracellular localization transcription, inhibited 16442531 1 0 0 +Opn4 melanopsin GPCR, family 1; Membrane protein, integral; Membrane protein, multi-pass; Receptor, GPCR Q8R456 192223 16p15 rat S398-p 36745801 SSQSSDLsWISGQKR activity, induced 25378407 1 0 0 increases Ca2+ response +ABL2 Arg EC 2.7.10.2; KINASE; Kinase, protein; Oncoprotein; Protein kinase, TK; Protein kinase, tyrosine (non-receptor) P42684 27 1q25.2 human Y310-p 456544 YVGVWKKySLTVAVK PK_Tyr_Ser-Thr enzymatic activity, induced 34144039 1 4 56 +IKBKB IKKB EC 2.7.11.10; KINASE; Kinase, protein; Protein kinase, Other; Protein kinase, Ser/Thr (non-receptor) O14920 3551 8p11.21 human K238-ub 1881186500 WHSKVRQkSEVDIVV molecular association, regulation; phosphorylation NFkB-p105(DISRUPTS) 33523871 1 1 0 ubiquitylation inhibits phosphorylation of p105 +Mecp2 MECP2 Transcription, coactivator/corepressor Q9Z2D6 17257 X A7.3|X 37.63 cM mouse K223-sm 31089522 SPGKLVVkMPFQASP molecular association, regulation neural plasticity; transcription, inhibited HDAC1(INDUCES); HDAC2(INDUCES) 24188180 1 0 0 +SLC7A5 SLC7A5 Membrane protein, integral; Membrane protein, multi-pass; Transporter; Transporter, SLC family Q01650 8140 16q24.2 human K25-ub 21185156 EKEEAREkMLAAKSA protein degradation endocytosis, induced 31728037 1 5 0 PMA-induced endocytosis +PRKCA PKCA EC 2.7.11.13; KINASE; Kinase, protein; Oncoprotein; Protein kinase, AGC; Protein kinase, Ser/Thr (non-receptor) P17252 5578 17q24.2 human Y658-p 455927 SDFEGFSyVNPQFVH Pkinase_C intracellular localization 16627824 5 0 0 +Nefm NFM Cytoskeletal P08553 18040 14|14 D1 mouse S506-p 448042 AEKSPVKsPEAKEEE cytoskeletal reorganization 19193875 3 5 6 slightly altered axoplasmic organization in 7S/A mice mutant +Clock CLOCK ACETYLTRANSFERASE; Acetyltransferase; DNA-binding; EC 2.3.1.48; Transcription factor O08785 12753 5 C3.3|5 40.63 cM mouse S42-p 7911902 KRVSRNKsEKKRRDQ HLH protein degradation; intracellular localization transcription, inhibited DNA(DISRUPTS) 19414601 1 1 0 inhibits transcription +Lpcat1 LPCAT1 ACETYLTRANSFERASE; Acetyltransferase; EC 2.3.1.23; EC 2.3.1.67; Endoplasmic reticulum; Membrane protein, integral Q3TFD2 210992 13|13 C1 mouse S182-p 17533101 VSRSDQDsRRKTVEE Acyltransferase protein degradation; ubiquitination 21068446 1 0 0 +Lima1 eplin Actin-binding; Cytoskeletal; Motility/polarity/chemotaxis Q9ERG0 65970 15 F1|15 56.13 cM mouse S692-p 460654 NHVHAQQsPLEPEAP molecular association, regulation cell motility, induced; cytoskeletal reorganization ACTB(DISRUPTS) 17875928 1 27 26 destabilization of stress fibres, membrane ruffle formation +L3MBTL2 L3MBTL2 Histone-binding Q969R5 83746 22q13.2 human K675-sm 31089506 EIIAVRVkEEHLDVA ubiquitination transcription, inhibited 24369422 2 2 0 induces Histone ubiquitination +RELA NFkB-p65 DNA-binding; Nuclear receptor co-regulator; Transcription factor Q04206 5970 11q13.1 human R174-m2 54221300 DPSGRPLrLPPVLSH RHD_DNA_bind transcription, induced DNA(INDUCES) 26901772 1 1 0 expression of CXCL11 +Irf1 IRF1 Transcription factor; Tumor suppressor P15314 16362 11 B1.3|11 32.0 cM mouse T181-p 1380568700 LDMERDItPALSPCV protein degradation; molecular association, regulation; ubiquitination cell growth, inhibited; transcription, induced FBXW7(INDUCES) 30854564 1 0 0 de-stabilization of chromatin-associated IRF1; induced expression of TRAIL, OAS3, PSMA6, and TBC1D32; RNA-Pol-II elongation; anti-proliferative activity in cancer cells +CCAR2 DBC-1 Apoptosis; Mitochondrial; Nuclear receptor co-regulator; RNA-binding; Tumor suppressor Q8N163 57805 8p21.3 human K112-ac 31068002 AVPWNAVkVQTLSNQ S1-like molecular association, regulation apoptosis, induced; transcription, inhibited SIRT1(DISRUPTS) 23892437; 24126058 2 2 0 +NUMA1 NuMA-1 Cell cycle regulation; Motility/polarity/chemotaxis Q14980 4926 11q13.4 human T1804-p 3196649 FLDSGRKtRSARRRT intracellular localization cell growth, induced; apoptosis, inhibited 23097092 1 3 1 cell proliferation increased +Cd22 CD22 Cell surface; Membrane protein, integral P35329 12483 7 B1|7 19.26 cM mouse Y817-p 459310 NNSDSVTySVIQKRP molecular association, regulation; phosphorylation SHP-1(INDUCES) 18024433 3 2 5 +Ret Ret EC 2.7.10.1; KINASE; Kinase, protein; Membrane protein, integral; Oncoprotein; Protein kinase, TK; Protein kinase, tyrosine (receptor) P35546 19713 6 F1|6 55.86 cM mouse Y1063-p 447625 TWIENKLyGMSDPNW molecular association, regulation; enzymatic activity, induced cell growth, induced; transcription, induced; cytoskeletal reorganization DOK4(INDUCES); DOK2(INDUCES); DOK1(INDUCES); DOK5(INDUCES) 11470823; 12087092; 25970250; 33561442 42 2 2 +SDC2 syndecan-2 Cell adhesion; Cell surface; Membrane protein, integral; Motility/polarity/chemotaxis P34741 6383 8q22.1 human Y179-p 448375 RKKDEGSyDLGERKP Syndecan molecular association, regulation RACK1(INDUCES) 16997272 2 2 6 +Cd5 CD5 Cell surface; Membrane protein, integral P13379 12507 19 A|19 7.16 cM mouse Y464-p 450105 RNSHLSAyPALEGAL molecular association, regulation PIK3R1(NOT_REPORTED) 9079809 4 1 22 +EHHADH EHHADH Amino Acid Metabolism - lysine degradation; Amino Acid Metabolism - tryptophan; Amino Acid Metabolism - valine, leucine and isoleucine degradation; Carbohydrate Metabolism - butanoate; Carbohydrate Metabolism - propanoate; EC 1.1.1.35; EC 4.2.1.17; EC 5.3.3.8; Isomerase; Lipid Metabolism - fatty acid; Lyase; Mitochondrial; Other Amino Acids Metabolism - beta-alanine; Oxidoreductase; Secondary Metabolites Metabolism - limonene and pinene degradation Q08426 1962 3q27.2 human K584-ac 461837 KGWYQYDkPLGRIHK enzymatic activity, induced 20167786 0 7 24 +SIK2 QIK EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, CAMK; Protein kinase, Ser/Thr (non-receptor) Q9H0K1 23235 11q23.1 human S587-p 3212040 FREGRRAsDTSLTQG enzymatic activity, inhibited 24841198 4 35 17 +Map3k5 ASK1 EC 2.7.11.25; KINASE; Kinase, protein; Protein kinase, STE; Protein kinase, Ser/Thr (non-receptor) O35099 26408 10|10 A3 mouse S973-p 447736 NEYLRSIsLPVPVLV enzymatic activity, inhibited; phosphorylation apoptosis, induced; transcription, altered 19920149; 36418313 17 4 1 inhibits JNK phosphorylation +MYBL2 B-Myb DNA-binding; Motility/polarity/chemotaxis; Transcription factor P10244 4605 20q13.12 human S577-p 450115 RKPGLRRsPIKKVRK Cmyb_C molecular association, regulation; protein conformation; phosphorylation cell cycle regulation; transcription, induced PIN1(INDUCES); B-Myb(DISRUPTS) DNA(DISRUPTS) 32979888 5 0 0 primes for phosphorylation at T487 +STIM1 STIM1 Calcium-binding; Endoplasmic reticulum; Membrane protein, integral Q13586 6786 11p15.4 human Y316-p 1870020002 NERSRQKyAEEELEQ molecular association, regulation; activity, inhibited ORAI1(INDUCES); TMEM66(DISRUPTS) 30975919 1 0 0 +IRF9 IRF9 DNA-binding; Transcription factor Q00978 10379 14q12 human S252-p 1881230100 AEPSGSEsSMEQVLF transcription, altered 36662450 1 1 0 +ITM2A ITM2A Membrane protein, integral O43736 9452 Xq21.1 human T35-p 1869192400 TVRTQILtGKELRVA enzymatic activity, induced carcinogenesis, inhibited; autophagy, induced 31438969 1 1 0 mTOR enzymatic activity induced +FLNB FLNB Actin-binding; Motility/polarity/chemotaxis O75369 2317 3p14.3 human K1147-ub 27583503 GPGLEHGkVGEAGLL Filamin molecular association, regulation; intracellular localization HDAC7(INDUCES) 23401860 1 0 0 PMA treatment enhances ubiquitination of FLNB and led to an increase in HDAC7 cytoplasmic accumulation. +BRCA1 BRCA1 EC 6.3.2.-; Nuclear receptor co-regulator; Transcription, coactivator/corepressor; Tumor suppressor; UBIQUITIN LIGASE; Ubiquitin conjugating system; Ubiquitin ligase P38398 672 17q21.31 human T1394-p 1874020208 SQSDILTtQQRDTMQ cell cycle regulation; carcinogenesis, altered; DNA repair, altered 34301763 1 1 0 +HSP90AA1 HSP90A Chaperone; Heat shock protein P07900 3320 14q32.31 human K292-ac 2884403 IDQEELNkTKPIWTR HSP90 molecular association, regulation TEBP(DISRUPTS); HSP70(DISRUPTS); HSP40(DISRUPTS) 18559531 1 6 2 +Ccne1 CCNE1 Activator; Cell cycle regulation; Nuclear receptor co-regulator Q61457 12447 7 B3|7 25.35 cM mouse T74-p 454411 DPCSFIPtPNKEEDN protein degradation; ubiquitination; methylation; activity, inhibited; phosphorylation cell cycle regulation; cell differentiation, altered; cell differentiation, induced; apoptosis, inhibited; DNA repair, altered; transcription, altered; cell growth, altered 18559482; 23873023; 24958101 8 1 0 using knock-in mutations impaired Fbw7-mediated degradation; T74A/T393A mutation causes increased Cdk2 kinase activity and stability and regulation by Fbw7. ; required for HSCs' multilineage reconstitution ability, and prevention of chromosome instability (CIN); regulation of oxidative metabolism and ROS production during terminal maturation; Phosphorylation at T74 and T393 causes dephosphorylation of Rb and demethylation of H3K9 +PTEN PTEN Carbohydrate Metabolism - inositol phosphate; EC 3.1.3.16; EC 3.1.3.48; EC 3.1.3.67; Motility/polarity/chemotaxis; Nuclear receptor co-regulator; PHOSPHATASE; Phosphatase, lipid; Tumor suppressor P60484 5728 10q23.31 human S370-p 448649 TSVTPDVsDNEPDHY molecular association, regulation; protein stabilization; intracellular localization; enzymatic activity, inhibited PTEN(DISRUPTS); RAD52(INDUCES) 11035045; 17565999; 24047694 12 7 0 facilitates translocation to chromatin and interaction with RAD52 +AMD1 AMD1 Amino Acid Metabolism - arginine and proline; Amino Acid Metabolism - cysteine and methionine; EC 4.1.1.50; Lyase P17707 262 6q21 human S298-p 3181139 KCRTVLAsPQKIEGF SAM_decarbox protein stabilization 28658205 1 6 0 +FDX1 adrenodoxin Mitochondrial P00257 281157 cow T129-p 455475 FEKLEAItDEENDML Fer2 molecular association, regulation CYP11A1(INDUCES) 15751958; 17358057 2 4 0 +Map2k1 MEK1 EC 2.7.12.2; KINASE; Kinase, protein; Protein kinase, STE; Protein kinase, dual-specificity (non-receptor) P31938 26395 9 C|9 34.55 cM mouse S222-p 448513 LIDSMANsFVGTRSY Pkinase enzymatic activity, induced cell growth, altered 10749122; 16103085; 7731726 117 20 203 +CGAS cGAS EC 2.7.7.86 Q8N884 115004 6q13 human K414-ub 12389582 KDCLKLMkYLLEQLK Mab-21_C protein degradation; molecular association, regulation autophagy, induced; signaling pathway regulation SQSTM1(INDUCES) 27666593 2 3 4 promotes type I-interferon signaling +Nlrp3 NLRP3 Inhibitor Q8R4B8 216799 11|11 B1.3 mouse K380-ub 1881493601 KRKEYFFkYFSNELQ NACHT protein degradation 33976226 1 0 0 +TGFB1 TGFB1 Motility/polarity/chemotaxis; Secreted; Secreted, signal peptide P01137 7040 19q13.2 human K315-ub 1881978301 WKWIHEPkGYHANFC TGF_beta protein degradation 35701426 1 1 0 p62-dependent autophagic degradation of TGFB1 +CDC25B CDC25B EC 3.1.3.48; Motility/polarity/chemotaxis; Nuclear receptor co-regulator; PHOSPHATASE; Protein phosphatase, dual-specificity P30305 994 20p13 human S375-p 455380 ARVLRSKsLCHDEIE M-inducer_phosp molecular association, regulation 14-3-3 beta(INDUCES) 11333986 4 24 2 +TGS1 PIMT EC 2.1.1.-; METHYLTRANSFERASE; Methyltransferase; Nuclear receptor co-regulator; RNA processing Q96RS0 96764 8q12.1 human S656-p 1881245402 AQRYRLFsRFDDGIK molecular association, regulation; phosphorylation transcription, altered; signaling pathway regulation p300(INDUCES) 36866247 1 0 0 induces PKA-PIMT-Ep300 signaling, regulates AKT phosphorylation +SHC4 SHC4 Adaptor/scaffold Q6S5L8 399694 15q21.1 human Y374-p 3654466 EEREDHEyYNEIPGK molecular association, regulation SHP-2(INDUCES) 28213521 1 2 4 +LMNA lamin A/C Cytoskeletal P02545 4000 1q22 human S390-p 452605 EEERLRLsPSPTSQR activity, induced; intracellular localization; phosphorylation chromatin organization, altered; DNA repair, inhibited 18815303; 37378334 5 119 129 induces H2AX phosphorylation; nuclear lamin disassemby +GRHL3 GRHL3 DNA-binding; Transcription factor Q8TE85 57822 1p36.11 human T454-p 1077816900 RPETDLEtPPVLFIP transcription, inhibited 29702134 1 1 0 +Ncam1 NCAM1 Cell adhesion; Membrane protein, GPI anchor; Membrane protein, integral; Motility/polarity/chemotaxis P13596 24586 8q23 rat S784-p 456432 AAFSKDEsKEPIVEV molecular association, regulation CRMP-2(INDUCES) 23377853 2 32 2 +MCM2 MCM2 DNA-binding; EC 3.6.4.12 P49736 4171 3q21.3 human S40-p 452311 RRTDALTsSPGRDLP molecular association, regulation; enzymatic activity, induced cell cycle regulation; carcinogenesis, induced; chromatin organization, altered; apoptosis, inhibited; cell growth, altered DNA(INDUCES) 16446360; 17062569; 25843623; 28273463; 31578521 12 29 18 loss of CDC7 induce senescence in liver cancer cells +PTK2 FAK EC 2.7.10.2; KINASE; Kinase, protein; Protein kinase, TK; Protein kinase, tyrosine (non-receptor) Q05397 5747 8q24.3 human S732-p 450196 SSEGFYPsPQHMVQT cell motility, altered; cell adhesion, altered 16760434 5 1 0 triggers the formation of the ventral focal adhesions +Wwtr1 TAZ Oncoprotein; Transcription, coactivator/corepressor Q9EPK5 97064 3|3 D mouse S89-p 457660 AQHVRSHsSPASLQL molecular association, regulation; intracellular localization transcription, inhibited 14-3-3 epsilon(INDUCES); 14-3-3 epsilon(DISRUPTS) 11118213; 25362852; 25961935; 35619099 31 20 79 +HIPK2 HIPK2 EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, CMGC; Protein kinase, Ser/Thr (non-receptor) Q9H2X6 28996 7q34 human Y367-p 1033356 TYLQSRYyRAPEIIL Pkinase protein stabilization; intracellular localization apoptosis, induced; transcription, induced 25944899 1 1 0 +PDGFRB PDGFRB EC 2.7.10.1; KINASE; Kinase, protein; Membrane protein, integral; Oncoprotein; Protein kinase, TK; Protein kinase, tyrosine (receptor) P09619 5159 5q32 human Y771-p 447517 ADIESSNyMAPYDNY PK_Tyr_Ser-Thr molecular association, regulation RASA1(INDUCES); Arg(INDUCES); SHC1(INDUCES) 11896619; 1314164; 1375321; 34144039; 7935391; 8195171 14 4 5 Y579 most important for Shc binding. Phosphorylation of Shc not dependent on individual PDGFRB sites. +BCR Bcr EC 2.7.11.1; GAP; GAP, Rac/Rho; GEF, Rac/Rho; KINASE; Kinase, protein; Oncoprotein; Protein kinase, Ser/Thr (non-receptor); Protein kinase, atypical P11274 613 22q11.23 human S354-p 447791 SGQSSRVsPSPTTYR molecular association, regulation apoptosis, induced Abl iso2(INDUCES) 11809685 3 13 60 +Bach2 BACH2 DNA-binding; Transcription factor P97303 12014 4|4 A5 mouse K201-sm 2798314 TAIPVAEkEEALLPE intracellular localization transcription, inhibited 15060166 2 0 0 formation of PML bodies +RB1 Rb Nuclear receptor co-regulator; Oncoprotein; Transcription, coactivator/corepressor; Tumor suppressor P06400 5925 13q14.2 human S788-p 450022 PIPHIPRsPYKFPSS Rb_C molecular association, regulation cell growth, altered E2F1(DISRUPTS); TFDP1(DISRUPTS) 16360038; 9315635 12 20 79 +IKBKB IKKB EC 2.7.11.10; KINASE; Kinase, protein; Protein kinase, Other; Protein kinase, Ser/Thr (non-receptor) O14920 3551 8p11.21 human Y188-p 449632 SFVGTLQyLAPELLE Pkinase activity, induced transcription, altered 12645577; 12707358 6 0 0 +Vim Vimentin Cytoskeletal; Motility/polarity/chemotaxis P20152 22352 2 A1|2 10.04 cM mouse S8-p 471087 MSTRSVSsSSYRRMF Filament_head molecular association, regulation endocytosis, induced JAG1(INDUCES) 28533359 3 3 1 transendocytosis +XRCC1 XRCC1 DNA repair, damage P18887 7515 19q13.31 human T284-p 5014905 APTRTPAtAPVPARA activity, induced; molecular association, regulation cell growth, altered MPG(INDUCES); CCNO(INDUCES) 18971944 1 1 0 promotes base excision repair +USP25 USP25 DEUBIQUITINASE; EC 3.4.19.12; Protease; Ubiquitin conjugating system; Ubiquitin-specific protease Q9UHP3 29761 21q21.1 human K141-sm 3084636 EASIAENkACLKRTP ubiquitination; enzymatic activity, inhibited 18538659 1 0 0 sumoylation inhibits ubiquitin chain hydrolysis and has reduced afinity to ubiquitin chains +SMAD4 SMAD4 DNA-binding; Nuclear receptor co-regulator; Transcription, coactivator/corepressor Q13485 4089 18q21.2 human K519-ub 7388009 DYPRQSIkETPCWIE MH2 protein degradation cell differentiation, induced; signaling pathway regulation 19135894; 28468752 2 3 0 TGF-beta signaling; inhibits Activin-BMP signaling +GALNT2 GALNT2 EC 2.4.1.41; Glycan Metabolism - O-glycan biosynthesis; Membrane protein, integral; Transferase Q10471 2590 1q42.13 human K103-ac 25336505 QDPYARNkFNQVESD enzymatic activity, inhibited; O-GalNAc glycosylation 21651894 0 1 0 inhibits glycosylation of mucin +PA2G4 Ebp1 Nuclear receptor co-regulator; Nucleolus; Transcription, coactivator/corepressor Q9UQ80 5036 12q13.2 human T261-p 2303906 QYGLKMKtSRAFFSE Peptidase_M24 activity, inhibited cell growth, induced; transcription, induced 18283314 2 0 0 +Map3k1 MEKK1 EC 2.7.11.25; KINASE; Kinase, protein; Ligase; Protein kinase, STE; Protein kinase, Ser/Thr (non-receptor); UBIQUITIN LIGASE; Ubiquitin conjugating system; Ubiquitin ligase P53349 26401 13 D2.2|13 63.36 cM mouse T1381-p 448078 ARLASKGtGAGEFQG Pkinase enzymatic activity, induced 25260751; 9078260 3 0 0 +Raf1 RAF1 EC 2.7.11.1; KINASE; Kinase, protein; Oncoprotein; Protein kinase, Ser/Thr (non-receptor); Protein kinase, TKL Q99N57 110157 6 E3|6 53.62 cM mouse S621-p 447746 PKINRSAsEPSLHRA protein stabilization; molecular association, regulation 14-3-3 beta(INDUCES); ROCK2(DISRUPTS); BRAF iso1(INDUCES) 11782426; 18922468; 28270557 24 70 10 +AR AR DNA-binding; Nuclear receptor; Transcription factor P10275 367 Xq12 human S215-p 448577 SGRAREAsGAPTSSK Androgen_recep activity, induced; protein degradation; molecular association, regulation; protein stabilization; ubiquitination; intracellular localization; activity, inhibited cell cycle regulation; carcinogenesis, induced; cell growth, induced; apoptosis, inhibited; transcription, induced; signaling pathway regulation; transcription, altered MDM2(INDUCES) 11404460; 17470458; 21601007; 22155408; 22584579; 29423094; 31429764 15 0 0 +NUMA1 NuMA-1 Cell cycle regulation; Motility/polarity/chemotaxis Q14980 4926 11q13.4 human S2087-p 28722901 TRSGTRRsPRIATTT cell growth, induced; apoptosis, inhibited 23097092 2 2 0 cell proliferation increased +Rasgrf1 RASGRF1 GEF; GEF, Ras P28818 192213 8q31 rat S898-p 448487 KEIYRRMsLANTGYS activity, induced; intracellular localization cytoskeletal reorganization; cell growth, altered 12538592 3 0 0 +PDE5A PDE5A EC 3.1.4.35; Nucleotide Metabolism - purine; Phosphodiesterase O76074 8654 4q26 human S104-p 36392501 PTRKISAsEFDRPLR enzymatic activity, inhibited; protein conformation 25247292 1 0 0 +GORASP2 GRASP55 Motility/polarity/chemotaxis; Vesicle Q9H8Y8 26003 2q31.1 human S189-p 31949801 SAWGGEGsLGCGIGY GRASP55_65 protein conformation 24505136 1 0 0 inhibits tethering +DSTN Destrin Actin-binding; Motility/polarity/chemotaxis P60981 11034 20p12.1 human S3-p 449754 _____MAsGVQVADE cytoskeletal reorganization; cell adhesion, altered 11171090 4 47 1 +ARAF ARAF EC 2.7.11.1; KINASE; Kinase, protein; Oncoprotein; Protein kinase, Ser/Thr (non-receptor); Protein kinase, TKL P10398 369 Xp11.3 human T442-p 3306325 IFLHEGLtVKIGDFG PK_Tyr_Ser-Thr enzymatic activity, induced 18662992 0 1 0 +WWOX WWOX Apoptosis; EC 1.1.1.-; Oxidoreductase; Tumor suppressor Q9NZC7 51741 16q23.1-q23.2 human Y33-p 449043 TTKDGWVyYANHTEE WW molecular association, regulation; intracellular localization; protein conformation; enzymatic activity, induced apoptosis, altered; carcinogenesis, inhibited; cell growth, inhibited; apoptosis, induced; transcription, induced; cell motility, inhibited; signaling pathway regulation; cell growth, induced HYAL2(INDUCES); TIAF1(INDUCES); p53(INDUCES); JNK1(DISRUPTS); p73(INDUCES); JNK1(INDUCES); p73(DISRUPTS) 12514174; 15070730; 15664696; 16115915; 16219768; 18371080; 19366691; 24899407; 26120275; 27845895; 31315632; 31752354; 32185845 21 1 0 in 4T1 cells; Erk/WWOX signaling +MS4A2 FcER1B Membrane protein, integral; Membrane protein, multi-pass; Receptor, misc. Q01362 2206 11q12.1 human Y219-p 454405 KVPEDRVyEELNIYS molecular association, regulation LYN(INDUCES) 15339926 2 1 0 +COL17A1 COL17A1 Extracellular matrix; Membrane protein, integral; Motility/polarity/chemotaxis Q9UMD9 1308 10q25.1 human S542-p 484006 LDKIGLHsDSQEELW cell adhesion, altered 17545155 1 0 0 regulates COL17A1 shedding of ectodomain +Cct2 CCT2 Chaperone P80314 12461 10|10 D2 mouse S260-p 472352 GSRVRVDsTAKVAEI Cpn60_TCP1 molecular association, regulation 21440620 3 19 249 chaperonin protein folding +MAP2K4 MKK4 EC 2.7.12.2; KINASE; Kinase, protein; Protein kinase, STE; Protein kinase, dual-specificity (non-receptor) P45985 6416 17p12 human K140-ub 11998604 IRSTVDEkEQKQLLM Pkinase protein degradation 19737936 1 0 0 +CALR Calreticulin ACETYLTRANSFERASE; Acetyltransferase; Calcium-binding; Motility/polarity/chemotaxis; Nuclear receptor co-regulator; Secreted; Secreted, signal peptide P27797 811 19p13.13 human K62-ac 4219815 KFYGDEEkDKGLQTS Calreticulin protein conformation 18795239 1 3 0 +Stk39 STLK3 EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, STE; Protein kinase, Ser/Thr (non-receptor) Q9Z1W9 53416 2|2 C1.3 mouse S383-p 456506 VRRVPGSsGHLHKTE intracellular localization; phosphorylation; enzymatic activity, induced 20463172; 23940364; 24808538; 25651563; 26108786 20 20 1 apical phosphorylation at the apical membrane of DCT segments that is absent in SPAK KO mice; Increased phosphorylation of T96 and T101 of NKCC2; Regulatory volume increase (RVI) induced. Activity of NKCC1 cotransporter induced +PPP1R2 PPP1R2 Inhibitor; Motility/polarity/chemotaxis; Protein phosphatase, regulatory subunit P41236 5504 3q29 human S72-p 3190237 LMKIDEPsTPYHSMM IPP-2 cell motility, altered 26590424 2 1 0 +CACNA1C CACNA1C Channel, calcium; Membrane protein, integral; Membrane protein, multi-pass BAA34185.2 guinea pig S1699-p 4714250 PEIRRAIsGDLTAEE CAC1F_C activity, induced; molecular association, regulation; protein conformation Calmodulin(DISRUPTS) 30042022 17 7 0 +MEF2C MEF2C DNA-binding; Transcription factor Q06413 4208 5q14.3 human K239-ac 12674407 LNKNMQAkSPPPMNL molecular association, regulation cell differentiation, induced; transcription, induced MRF(INDUCES) DNA(INDUCES) 15831463 1 0 0 +MUS81 MUS81 Deoxyribonuclease; EC 3.1.22.-; Nucleolus Q96NY9 80198 11q13.1 human K10-sm 1872852104 APVRLGRkRPLPACP cell cycle regulation; DNA repair, induced 28318385 1 0 0 regulates genomic stability and chromosome alignment +MAP3K5 ASK1 EC 2.7.11.25; KINASE; Kinase, protein; Protein kinase, STE; Protein kinase, Ser/Thr (non-receptor) Q99683 4217 6q23.3 human T825-p 34366326 LKISDFGtSKRLAGI Pkinase protein conformation; enzymatic activity, induced apoptosis, induced; transcription, induced 28888991 1 0 1 dimerization +VIM Vimentin Cytoskeletal; Motility/polarity/chemotaxis P08670 7431 10p13 human K120-ac 475919 RFANYIDkVRFLEQQ Filament carcinogenesis, induced; cell motility, induced 30659753; 30662803 2 8 3 EMT in HCC +Stk11 LKB1 Autophagy; EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, CAMK; Protein kinase, Ser/Thr (non-receptor); Tumor suppressor Q9WTK7 20869 10|10 C1 mouse S431-p 448147 SNKIRRLsACKQQ__ intracellular localization; phosphorylation; enzymatic activity, induced carcinogenesis, inhibited; autophagy, induced; cell differentiation, induced; apoptosis, inhibited; cytoskeletal reorganization; cell growth, altered BRSK1(INDUCES); AMPKA1(INDUCES); Tau(INDUCES) 11297520; 17482548; 17482549; 31930700; 34006524 33 2 3 +PHKB PHKB KINASE; Protein kinase, regulatory subunit P12798 100009137 rabbit S27-p 470138 ARTKRSGsVYEPLKS molecular association, regulation 17123541 2 26 6 Mutations of S12 and S27 increased Beta subunit self interactions. +KCNQ3 Kv7.3 Channel, potassium; Membrane protein, integral; Membrane protein, multi-pass O43525 3786 8q24.22 human T246-p 457688 RMDRRGGtWKLLGSA Ion_trans; TM activity, induced 16319223 1 1 0 +NFATC2 NFAT1 DNA-binding; Transcription factor Q13469 4773 20q13.2 human S79-p 628303302 YSPLASLsGEPPGRF molecular association, regulation; intracellular localization transcription, induced PPP3CA(INDUCES) 29357353 1 0 0 nuclear translocation, TCR-mediated IL-2 and TNF-alpha production +Sgo1 SGO1 Cell cycle regulation Q9CXH7 72415 17|17 C mouse S73-p 2535906 LALENEKsKVREAQD intracellular localization 18331714 1 0 0 S73A and T146A mutants do not localize to the spindle pole region +Mitf MITF iso8 DNA-binding; Oncoprotein; Transcription factor Q08874-8 17342 6 D3|6 45.05 cM mouse K316-sm 3590700 DLVNRIIkQEPVLEN DUF3371 molecular association, regulation transcription, inhibited hnRNP P2(DISRUPTS); SMARCA4(DISRUPTS) 24257758 3 1 0 +Tph1 TPH1 Amino Acid Metabolism - tryptophan; EC 1.14.16.4; Oxidoreductase P09810 rat S58-p 451575 RKSKRRNsEFEIFVD enzymatic activity, induced 9109552 4 1 0 +Tgif1 TGIF DNA-binding; Nuclear receptor co-regulator; Transcription, coactivator/corepressor P70284 21815 17|17 E1.3 mouse K259-ub 12159004 LLVDVALkRAAEMEL protein stabilization 20064471 1 0 0 +Dapk1 DAPK1 Apoptosis; Autophagy; EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, CAMK; Protein kinase, Ser/Thr (non-receptor) Q80YE7 69635 13 B2|13 32.53 cM mouse S308-p 448142 ARKKWKQsVRLISLC protein degradation; molecular association, regulation; enzymatic activity, inhibited apoptosis, altered; apoptosis, induced CHIP(DISRUPTS); NMDAR2B(DISRUPTS); MIB1(DISRUPTS); Calmodulin(DISRUPTS) 15729359; 17056602; 17324930; 18806755; 20141836; 28614711 11 4 0 +RAF1 RAF1 EC 2.7.11.1; KINASE; Kinase, protein; Oncoprotein; Protein kinase, Ser/Thr (non-receptor); Protein kinase, TKL P04049 5894 3p25.2 human S624-p 18014563 NRSASEPsLHRAAHT molecular association, regulation; phosphorylation BRAF(DISRUPTS); 14-3-3 beta(DISRUPTS) 37625591 1 4 0 inhibits phosphorylation of itself at S338 and also MEK phosphorylation +RICTOR RICTOR Adaptor/scaffold; Cell cycle regulation; Ubiquitin conjugating system Q6R327 253260 5p13.1 human K1116-ac 41692100 HRSSSDPkGGKLSSE RICTOR_phospho signaling pathway regulation 26170313 1 0 0 induces mTORC2 signaling +NEK2 NEK2 EC 2.7.11.1; KINASE; Kinase, protein; Nucleolus; Protein kinase, Other; Protein kinase, Ser/Thr (non-receptor) P51955 4751 1q32.3 human T170-p 4271902 ARILNHDtSFAKTFV Pkinase enzymatic activity, induced 17197699 1 1 0 +DCX Doublecortin iso2 Cytoskeletal; Motility/polarity/chemotaxis O43602-2 1641 Xq23 human S334-p 451359 SPISTPTsPGSLRKH intracellular localization cell motility, altered; cytoskeletal reorganization 14765123 4 5 17 affects doublecortin localization to growth cones, neurite outgrowth, and neuronal motility +GIT2 GIT2 GAP; GAP, ARF; Motility/polarity/chemotaxis Q9Y621 374035 chicken Y392-p 456754 QDNDQPDyDSVASDE molecular association, regulation; intracellular localization cell adhesion, altered PXN(INDUCES) 16000375 1 6 25 +RHOU RHOU G protein; G protein, monomeric; G protein, monomeric, Rho; Motility/polarity/chemotaxis Q7L0Q8 58480 1q42.13 human Y254-p 14918203 SKSWWKKyCCFV___ molecular association, regulation; intracellular localization; activity, inhibited cytoskeletal reorganization; cell growth, altered PAK1(DISRUPTS) 20547754 1 0 0 +HDAC1 HDAC1 DEACETYLASE; Deacetylase; EC 3.5.1.98; Hydrolase; Nuclear receptor co-regulator Q13547 3065 1p35.2-p35.1 human S423-p 447913 CEEEFSDsEEEGEGG molecular association, regulation; enzymatic activity, induced SIN3A(INDUCES) 11602581 1 69 39 +GYS1 GYS1 Carbohydrate Metabolism - starch and sucrose; EC 2.4.1.11; Transferase P13807 2997 19q13.33 human S8-p 449898 MPLNRTLsMSSLPGL enzymatic activity, inhibited 19339242; 35793618 16 1 0 +STAT3 STAT3 DNA-binding; Motility/polarity/chemotaxis; Nuclear receptor co-regulator; Transcription factor P40763 6774 17q21.2 human K685-ac 458927 PKEEAFGkYCRPESQ activity, induced; protein stabilization; molecular association, regulation; methylation; intracellular localization; phosphorylation cell differentiation, inhibited; cell cycle regulation; carcinogenesis, induced; cell motility, induced; transcription, induced; signaling pathway regulation; cell differentiation, induced; cell growth, induced; apoptosis, inhibited; transcription, inhibited DMAP1(INDUCES); STAT3(INDUCES); CD44(INDUCES); DNMT1(INDUCES); ER-alpha(INDUCES) DNA(INDUCES) 15649887; 17917251; 19506034; 21098725; 21701559; 22116549; 26675255; 27086926; 27582487; 28445726; 29137356; 31170499; 31409371; 32393833; 33446662; 33859766 27 2 0 Acetylated STAT3 upon HDAC inhibition was protected fom degradation and induced transcription of IGF2, developing resistance to HDI treatment.; downregulation of CAV1 activates AKT pathway inducing cellular transformation; translocation of acetylated STAT3 into mitochondria after glutamate stimulation; enhanced methylation of GATA6, HDAC1/2 inhibition on and VCAM-1 expression; transcriptional increase in IGF2 expression in vorinostat-resistant NSCLC cells; SIRT1 activation inhibitss Th17 cell differentiation through STAT3 deacetylation; ER-alpha mediates both phosphorylation and acetylation of STAT3 at 1 h upon IL-6 treatment, ER-alpha recruits p300 and mediates IL-6-induced STAT3 acetylation, ER-alpha-STAT3 complex binding to the MMP2 and MMP9 promoter, leading to transcription and breast cancer cell migration; interaction between acetylated STAT3 and the CAV1 promoter +NFATC1 NFAT2 DNA-binding; Transcription factor O95644 4772 18q23 human S335-p 1869090800 GDGVPVKsRKTTLEQ activity, induced carcinogenesis, induced; cell motility, induced; transcription, induced 31730483 1 1 0 multiple sites mutatnt +MCL1 MCL1 Apoptosis; Channel, misc.; Inhibitor; Membrane protein, integral; Mitochondrial Q07820 4170 1q21.2 human K136-ub 10843917 YEPEPLGkRPAVLPL protein degradation 28522751 2 2 10 +PRKCD PKCD EC 2.7.11.13; KINASE; Kinase, protein; Nuclear receptor co-regulator; Protein kinase, AGC; Protein kinase, Ser/Thr (non-receptor); Protein kinase, tyrosine (non-receptor); Tumor suppressor Q05655 5580 3p21.1 human T295-p 4272376 AEALNQVtQRASRRS enzymatic activity, induced 19366211 3 5 1 +TBC1D1 TBC1D1 DEUBIQUITINASE; GAP; GAP, Rab; Ubiquitin-specific protease Q86TI0 23216 4p14 human S237-p 2103609 RPMRKSFsQPGLRSL molecular association, regulation transcription, inhibited 14-3-3 sigma(INDUCES) 17995453; 35061665 10 43 97 destabilizes PPARG +Adcy6 ADCY6 Adenylyl cyclase; EC 4.6.1.1; Lyase; Membrane protein, integral; Membrane protein, multi-pass; Nucleotide Metabolism - purine; Transporter; Transporter, aquaporin family AAA40678 25289 7q36 rat S744-p 467272 PNALQRLsRSIVRSR enzymatic activity, induced 11327830; 15470083 2 0 0 increases potentiation +LATS2 LATS2 EC 2.7.11.1; KINASE; Kinase, protein; Nuclear receptor co-regulator; Protein kinase, AGC; Protein kinase, Ser/Thr (non-receptor); Tumor suppressor Q9NRM7 26524 13q12.11 human T168-gl 1869341905 GLMPTPVtRRPSFEG phosphorylation carcinogenesis, induced; cell growth, induced 32513743 1 1 0 inhibits phosphorylation at LATS2-S872 and T1041 +GARS1 GARS Aminoacyl-tRNA synthetase; EC 6.1.1.14; Ligase; Mitochondrial; Translation; Translation regulation P41250 2617 7p14.3 human S704-p 1352793601 AEISELPsIVQDLAN HGTP_anticodon molecular association, regulation; intracellular localization NFkB-p100(INDUCES) 30471104 1 0 0 +TP53BP1 53BP1 DNA repair, damage; Transcription, coactivator/corepressor Q12888 7158 15q15.3 human S25-p 450163 PCLIIEDsQPESQVL apoptosis, altered 19876065 3 0 0 +Sik1 SIK EC 2.7.11.1; KINASE; Kinase, protein; Motility/polarity/chemotaxis; Protein kinase, CAMK; Protein kinase, Ser/Thr (non-receptor); Tumor suppressor Q60670 17691 17 B1|17 17.25 cM mouse T182-p 456034 KPGEPLStWCGSPPY Pkinase enzymatic activity, induced 25918234 8 0 0 regulates CAMP levels and insulin secretion +ATP7B ATP7B EC 3.6.3.54; Hydrolase; Membrane protein, integral; Membrane protein, multi-pass; Transporter; Transporter, ion channel; Vesicle P35670 540 13q14.3 human S478-p 11267008 APDILAKsPQSTRAV protein stabilization; intracellular localization 21189263 1 4 0 protein trafficking +Nr2e3 NR2E3 Nuclear receptor Q9QXZ7 23958 9 B|9 32.35 cM mouse K322-sm 7324001 KPETRGLkDPEHVEA Hormone_recep transcription, inhibited 19186166 1 0 0 +HIPK2 HIPK2 EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, CMGC; Protein kinase, Ser/Thr (non-receptor) Q9H2X6 28996 7q34 human K805-ub 3059903 TTSSRKSkQHQSSVR protein degradation 18536714 1 0 0 +RAB8A RAB8A G protein; G protein, monomeric; G protein, monomeric, Rab; Motility/polarity/chemotaxis; Oncoprotein P61006 4218 19p13.11 human T72-p 4709152 AGQERFRtITTAYYR Ras receptor recycling, inhibited; molecular association, regulation; intracellular localization; activity, inhibited endocytosis, inhibited RAB3IP(DISRUPTS); RILPL2(INDUCES) 30709905; 32017888; 33887226; 34914695 13 5 6 +Vim Vimentin Cytoskeletal; Motility/polarity/chemotaxis P20152 22352 2 A1|2 10.04 cM mouse S10-p 455451 TRSVSSSsYRRMFGG Filament_head molecular association, regulation endocytosis, induced JAG1(INDUCES) 28533359 4 11 1 transendocytosis +MYC Myc DNA-binding; Nucleolus; Oncoprotein; Transcription factor P01106 4609 8q24.21 human K413-sm 40724406 PKVVILKkATAYILS HLH protein degradation; ubiquitination transcription, inhibited 25895136 1 2 0 +Irx3 IRX3 DNA-binding P81067 16373 8 C5|8 44.55 cM mouse S389-p 1874748506 APPTLQLsPAAAAAA molecular association, regulation; intracellular localization transcription, induced IRX3(INDUCES) 34556885 1 1 0 IRX3 dimerization, nuclear translocation +TRIM9 TRIM9 iso5 EC 6.3.2.-; UBIQUITIN LIGASE; Ubiquitin conjugating system; Ubiquitin ligase Q9C026-5 114088 14q22.1 human S80-p 1046182901 EADSGYGsYGGFASA protein stabilization 29669288 1 0 0 MKK6 enhances TRIM9s phosphorylation to inhibit Its ubiquitination +BCL11B Bcl-11B C2H2-type zinc finger protein; Nuclear receptor co-regulator; Transcription regulation Q9C0K0 64919 14q32.2 human S2-p 55578701 ______MsRRKQGNP molecular association, regulation transcription, induced MTA3(DISRUPTS); MTA1(DISRUPTS) 27161321 1 0 0 no effect on SUMOylation +NAT1 NAT1 ACETYLTRANSFERASE; Acetyltransferase; EC 2.3.1.5; Secondary Metabolites Metabolism - caffeine; Xenobiotic Metabolism - drug metabolism - other enzymes P18440 9 8p22 human K100-ac 1876800100 VYSTPAKkYSTGMIH Acetyltransf_2 molecular association, regulation; enzymatic activity, inhibited PPAT(DISRUPTS) 32487734 1 0 0 acetylation inhibited the allosteric effects of ATP on NAT1 +AXL AXL EC 2.7.10.1; KINASE; Kinase, protein; Membrane protein, integral; Oncoprotein; Protein kinase, TK; Protein kinase, tyrosine (receptor) P30530 558 19q13.2 human Y821-p 451491 QEPDEILyVNMDEGG molecular association, regulation; phosphorylation carcinogenesis, induced; cell growth, induced; signaling pathway regulation GRB2(INDUCES); PLCG1(INDUCES); PIK3R2(INDUCES); PIK3R1(INDUCES) 32439698; 9178760 2 1 0 induces phosphorylation and increases levels of c-Abl, regulates c-Abl signaling +REL REL Oncoprotein; Transcription factor Q04864 5966 2p16.1 human S523-p 1980801 SMNLENPsCNSVLDP activity, induced transcription, induced 16585559 1 0 0 Double mutant S491A S494 is not responsive to NIK-induced activation of transcription at the IL-2 promoter. The comparable site to S494 in mouse Rel is an alanine, so S491 may be the more important residue. +Irgm1 IRGM EC 3.6.5.-; Endoplasmic reticulum; Hydrolase Q60766 15944 11|11 B1.2 mouse K270-ub 15492001 TLYGTYEkIVGDKVA IIGP protein degradation 35197566 1 2 1 +KCNT1 KCNT1 Channel, potassium; Membrane protein, integral; Membrane protein, multi-pass Q5JUK3 57582 9q34.3 human S407-p 27259018 VLQIPLWsQRVIYLQ activity, induced; molecular association, regulation PHACTR1(INDUCES) 27545877 2 0 0 decreases KCNT1-associated mass at the plasma membrane +Slc12a2 NKCC1 Membrane protein, integral; Membrane protein, multi-pass; Transporter; Transporter, SLC family P55012 20496 18 D3|18 32.15 cM mouse T200-p 467236 YYDTHTNtYYLRTFG AA_permease_N activity, induced; enzymatic activity, induced 20463172; 26069258 12 1 0 Enzymatic activation by SLK3 requires two threonines separated by 4 amino acids. ; Ischemic cell death +OTUD5 OTUD5 DEUBIQUITINASE; EC 3.4.19.12; Protease; Ubiquitin-specific protease Q96G74 55593 Xp11.23 human S177-p 449291 EVGAGYNsEDEYEAA protein conformation; enzymatic activity, induced 22245969; 30232733; 32071088; 33417762 5 27 2 +NBN NBS1 Cell cycle regulation; DNA repair, damage O60934 4683 8q21.3 human K698-ac 487515 VTYPGAGkLPHIIGG Nbs1_C phosphorylation cell cycle regulation; apoptosis, induced 17612497 2 1 0 inhibits phosphorylation at S343 +Ets1 Ets-1 DNA-binding; Motility/polarity/chemotaxis; Oncoprotein; Transcription factor P27577 23871 9 A4|9 17.97 cM mouse K227-sm 3656300 QTDYFAIkQEVLTPD Ets1_N_flank transcription, inhibited 16729975; 16862185 2 0 0 +Cnr1 CNR1 GPCR, family 1; Membrane protein, integral; Membrane protein, multi-pass; Receptor, GPCR P20272 25248 5q21 rat T322-p 1871994101 QKSIIIHtSEDGKVQ 7tm_1 exocytosis, inhibited 33582301 1 0 0 +OSBP2 OSBP2 Q969R2 23762 22q12.2 human S766-p 15721694 VMHSSPSsPSSDGKQ Oxysterol_BP molecular association, regulation; protein conformation signaling pathway regulation Vimentin(INDUCES) 30925160 1 4 2 +Cilk1 ICK EC 2.7.11.22; KINASE; Kinase, protein; Protein kinase, CMGC; Protein kinase, Ser/Thr (non-receptor) Q9JKV2 56542 9|9 E1 mouse Y159-p 456052 SRPPYTDyVSTRWYR Pkinase enzymatic activity, induced 15988018 1 30 435 +YAP1 YAP1 iso2 Oncoprotein; Transcription, coactivator/corepressor P46937-2 10413 11q22.1 human S381-p 3190672 TYHSRDEsTDSGLSM protein degradation; ubiquitination; activity, inhibited; phosphorylation cell differentiation, induced; cell growth, inhibited; transcription, inhibited BTRC(INDUCES) 19141641; 20048001; 23027127; 23752589 32 13 5 +NFATC3 NFAT4 DNA-binding; Transcription factor Q12968 4775 16q22.1 human K384-sm 1881937804 LGSQYPLkKDSCGDQ molecular association, regulation; intracellular localization cell growth, inhibited; cell motility, inhibited GSK3B(INDUCES) 35484132 1 0 0 DeSUMOylation of NFATc3 by SENP3 promotes PDAC cell proliferation, migration, and invasion; NFATc3 K384 deSUMOylation by SENP3 increases nuclear translocation of NFATc3 by decreasing its interaction with GSK-3? +CCDC88A girdin Actin-binding Q3V6T2 55704 2p16.1 human Y1799-p 450762 QSKDSNPyATLPRAS molecular association, regulation; intracellular localization; phosphorylation cell differentiation, inhibited; carcinogenesis, induced; cell motility, induced; cytoskeletal reorganization PIK3R1(INDUCES) 21954290; 25707853; 26887938; 32307399 5 13 137 +BRCA1 BRCA1 EC 6.3.2.-; Nuclear receptor co-regulator; Transcription, coactivator/corepressor; Tumor suppressor; UBIQUITIN LIGASE; Ubiquitin conjugating system; Ubiquitin ligase P38398 672 17q21.31 human S1497-p 448730 EPGVERSsPSKCPSL molecular association, regulation; intracellular localization cell growth, induced ATM(INDUCES) 10550055; 19683496; 21706030 7 4 2 +TAF10 TAF10 Nuclear receptor co-regulator; Transcription initiation complex Q12962 6881 11p15.4 human K189-m3 57824500 GSSRSKSkDRKYTLT transcription, induced 25959397 1 0 0 oxidation inhibits transcription +VHL VHL Tumor suppressor; UBIQUITIN LIGASE; Ubiquitin ligase P40337 7428 3p25.3 human S38-p 15573200 EESGAEEsGPEESGP protein degradation transcription, altered 20637892; 26973240 2 0 0 VHL clevaage and subsequent degradation; regulates p53 activity and degradation of HIF1A +POU5F1 Oct4 DNA-binding; Transcription factor Q01860 5460 6p21.33 human K151-m1 57951804 KELEQFAkLLKQKRI Pou molecular association, regulation transcription, induced SOX2(INDUCES) 27369080 1 1 0 +Map2k1 MEK1 EC 2.7.12.2; KINASE; Kinase, protein; Protein kinase, STE; Protein kinase, dual-specificity (non-receptor) P31938 26395 9 C|9 34.55 cM mouse T292-p 448287 ETPPRPRtPGRPLSS Pkinase molecular association, regulation; enzymatic activity, inhibited; phosphorylation cell motility, induced; cell adhesion, altered; cell growth, altered ERK2(INDUCES) 12167697; 19219045 14 6 0 required to modulate phosphorylation of MEK1 and MEK2 heterodimer +HIC1 HIC1 C2H2-type zinc finger protein; Transcription factor; Tumor suppressor Q14526 3090 17p13.3 human S713-p 1872610000 DKAAEVLsQGAHLAA DNA repair, induced 33756345 1 1 0 +TRIM21 TRIM21 EC 6.3.2.-; Ligase; UBIQUITIN LIGASE; Ubiquitin conjugating system; Ubiquitin ligase P19474 6737 11p15.4 human K385-ac 1875282500 WTIWLWNkQKYEAGT SPRY molecular association, regulation TRIM21(DISRUPTS) 32796032 1 0 0 induces the antibody-dependent intracellular neutralization (ADIN) of the nonenveloped DNA virus adenovirus (AdV) type 5 ; Hyperacetylation of TRIM21 bLocks dimerization and ubiquitinalion +RIGI RIGI EC 3.6.4.13; Hydrolase O95786 23586 9p21.1 human K115-ub 62480701 KRLQPEFkTRIIPTD CARD_2 protein degradation transcription, inhibited 27506794 1 2 0 +SIRPA SHPS1 Cell adhesion; Cell surface; Membrane protein, integral; Motility/polarity/chemotaxis; Receptor, misc. P78324 140885 20p13 human Y470-p 451114 ASEDTLTyADLDMVH molecular association, regulation; phosphorylation cell motility, induced; cell growth, induced; signaling pathway regulation CTK(INDUCES); SHP-2(INDUCES); SHP-1(INDUCES) 10842184; 18233962; 21799000 5 8 18 regulation TLR3/4-dependent cytokine production pathway; Mutation of these 4 tyrosines does not affect JAK2 binding. However, overexpression of the WT SHPS1 but not the 4 tyrosine to phenylalanine mutation reduces tyrosine phosphorylation of Jak2, STAT5B, and STAT3 and activation of Erk1/2 in response to growth hormone. Does not affect STAT3 tyrosine phosphorylation in response to LIF agonist.; induces phosphorylation of itself at Y429 and Y453, and of MAPK, regulates SHPS1- signaling +IKBKG IKKG Adaptor/scaffold; Protein kinase, regulatory subunit Q9Y6K9 8517 Xq28 human S8-p 62382604 MNRHLWKsQLCEMVQ protein stabilization transcription, induced 27929056 1 0 0 +Scimp UNQ5783 Membrane protein, integral Q3UU41 327957 11|11 B3 mouse Y120-p 464680 STEPENDyDDVEIPA SCIMP molecular association, regulation transcription, induced GRB2(INDUCES); TLR4(INDUCES); CSK(INDUCES); Syk(INDUCES); TLR2(INDUCES); BLNK(INDUCES); TLR3(INDUCES); TLR1(INDUCES) 34496234; 35337798 2 2 6 +Rab10 RAB10 G protein; G protein, monomeric; G protein, monomeric, Rab P35281 50993 6q14 rat Y6-p 473923 __MAKKTyDLLFKLL molecular association, regulation MICAL3(INDUCES); MICAL1(INDUCES) 35227894 1 5 58 +CKAP4 CKAP4 Endoplasmic reticulum; Membrane protein, integral Q07065 10970 12q23.3 human S3-p 455353 _____MPsAKQRGSK molecular association, regulation; intracellular localization; palmitoylation neural plasticity; cell growth, inhibited; cytoskeletal reorganization; transcription, altered; signaling pathway regulation DNA(INDUCES) 15703217; 22265418; 22536245 3 0 0 +SAMD4B SAMD4B Unknown function Q5PRF9 55095 19q13.2 human S642-p 21688100 SSVQRTHsLPVHSSP molecular association, regulation 14-3-3 beta(INDUCES) 21725060 1 1 3 mutation of this site prevents 14-3-3 binding (pan-14-3-3 antibody) +HMGN2 HMGN2 DNA-binding P05204 3151 1p36.11 human K18-sm 33622401 KGDKAKVkDEPQRRS HMG14_17 protein stabilization; molecular association, regulation chromatin organization, altered; transcription, induced DNA(DISRUPTS) 24872413 1 0 0 +Ahrr AHRR Transcription factor Q3U1U7 11624 13|13 C1 mouse K542-sm 6423504 LSLDVPIkMENESGS molecular association, regulation transcription, inhibited ANKRA2(INDUCES); HDAC5(INDUCES); HDAC4(INDUCES) 19251700 1 0 0 +Pln PLB Inhibitor; Membrane protein, integral P61014 18821 10|10 B3 mouse S16-p 448114 RSAIRRAsTIEMPQQ Phospholamban activity, induced; protein degradation; molecular association, regulation PPP1R3A(DISRUPTS) 11861420; 24244723; 26966065 78 15 66 +DDIT3 DDIT3 Autophagy; DNA-binding; Oncoprotein; Transcription factor P35638 1649 12q13.3 human S82-p 448091 STSQSPHsPDSSQSS transcription, altered 8650547 1 1 0 CHOP-Gal-4 chimeric protein induced a reporter gene expression. +TUBA1A TUBA1A Cytoskeletal; Motility/polarity/chemotaxis Q71U36 7846 12q13.12 human S165-p 25757493 SVDYGKKsKLEFSIY Tubulin cell cycle regulation; carcinogenesis, inhibited; cell growth, inhibited; cytoskeletal reorganization; transcription, altered 30176291 1 0 1 S165D-high expression of N-cadherin while suppressing E-cadherin protein, whereas for 165N E-cadherin remains high, and N-cadherin is decreased +KRT6A K6a Cytoskeletal P02538 3853 12q13.13 human K180-ub 12292903 KFASFIDkVRFLEQQ Filament ubiquitination 29191848 1 6 7 +ESR2 ER-beta DNA-binding; Nuclear receptor Q92731 2100 14q23.2-q23.3 human Y36-p 34425602 SIYIPSSyVDSHHEY ERbeta_N molecular association, regulation; ubiquitination cell growth, inhibited; cell motility, inhibited; transcription, induced p300(INDUCES) 24960160; 27323858 2 0 0 +SNCA SNCA Adaptor/scaffold P37840 6622 4q22.1 human S87-p 449948 KTVEGAGsIAAATGF Synuclein molecular association, regulation apoptosis, induced SNCA(DISRUPTS); SNCA(INDUCES) 16959772; 28919642; 36690898 9 1 0 induces seeding of pathological a-Syn prepared from Lewy body disease (LBD) brains and inhibits seeding of pathological a-Syn prepared from multiple system atrophy brains ; reduces SNCA binding from the membrane ; promotes intracellular SNCA inclusion formation and increases cell's cytotoxicity +Trim28 TIF1B EC 6.3.2.-; KINASE; Kinase, protein; Ligase; Nuclear receptor co-regulator; Protein kinase, atypical; SUMO LIGASE; SUMO ligase; Transcription, coactivator/corepressor; UBIQUITIN LIGASE; Ubiquitin conjugating system; Ubiquitin ligase Q62318 21849 7|7 A1 mouse S473-p 452391 SGMKRSRsGEGEVSG molecular association, regulation; intracellular localization cell cycle regulation; transcription, induced; signaling pathway regulation; transcription, altered; DNA repair, induced; cell differentiation, induced; chromatin organization, altered; cell growth, induced; transcription, inhibited HDAC11(DISRUPTS); CBX1(DISRUPTS); EHMT2(DISRUPTS) 18590578; 22205726; 25737281; 33619215; 33657380 27 117 20 increase skeletal muscle size and regulates function through RSmTOR signaling; induce hypertrophy +CDKN1A p21Cip1 Cell cycle regulation; Inhibitor P38936 1026 6p21.2 human K161-ub 9897003 KRRLIFSkRKP____ protein degradation; ubiquitination cell cycle regulation; carcinogenesis, induced; cell growth, induced; apoptosis, inhibited 13678583; 17429006; 28446751; 35732617 5 0 0 +Snap23 SNAP23 Vesicle O70377 64630 3q35 rat S95-p 455262 NRTKNFEsGKNYKAT SNAP-25 molecular association, regulation; intracellular localization exocytosis, altered STX17(INDUCES); STX1A(INDUCES) 20967886; 33213278; 37057886 14 4 2 +UBE2N UBE2N DNA repair, damage; EC 6.3.2.19; Ligase; UBIQUITIN LIGASE; Ubiquitin conjugating system; Ubiquitin ligase P61088 7334 12q22 human K92-ub 3931511 RICLDILkDKWSPAL UQ_con protein conformation 32286321 1 9 156 ubiquitination is inhibited through competing with Ub to bind MavC +FOXO3 FOXO3A Autophagy; DNA-binding; Oncoprotein; Transcription factor O43524 2309 6q21 human S12-p 9318037 PASPAPLsPLEVELD transcription, induced 29445193 2 22 14 activate mitochondrial transcription in surviving cells, while the FoxO3A-S12A/S30A mutant contributed to apoptosis induction in metabolically stressed cancer cells. +MITF MITF DNA-binding; Oncoprotein; Transcription factor O75030 4286 3p13 human K308-ub 485779 SEARALAkERQKKDN protein degradation; molecular association, regulation autophagy, induced SQSTM1(INDUCES) 35092699 2 0 0 +Ar AR DNA-binding; Nuclear receptor; Transcription factor P19091 11835 X C3|X 42.82 cM mouse S794-p 1875398900 MKALLLFsIIPVDGL Hormone_recep molecular association, regulation; intracellular localization; activity, inhibited; phosphorylation carcinogenesis, altered; transcription, inhibited; transcription, altered; signaling pathway regulation AR(INDUCES) 34715066; 36470072 2 0 0 +MAPK4 ERK4 EC 2.7.11.24; KINASE; Kinase, protein; Protein kinase, CMGC; Protein kinase, Ser/Thr (non-receptor) P31152 5596 18q21.1-q21.2 human S186-p 2228602 YSHKGYLsEGLVTKW Pkinase molecular association, regulation MAPKAPK5(INDUCES) 18248330 1 14 2 +Nr2e3 NR2E3 Nuclear receptor Q9QXZ7 23958 9 B|9 32.35 cM mouse K178-sm 7324000 ITAETCAkLEPEDAE transcription, inhibited 19186166 1 0 0 +Rab13 RAB13 G protein; G protein, monomeric; G protein, monomeric, Rab Q9DD03 68328 3 F1|3 39.21 cM mouse K46-ub 1883494501 STIGIDFkIRTVDIE molecular association, regulation GDI1(DISRUPTS) 35343654 1 0 0 Promotes the Post-Golgi Tra?cking of TLR4 and TLR9 +LAT LAT Adaptor/scaffold; Membrane protein, integral O43561 27040 16p11.2 human Y220-p 448005 SLDGSREyVNVSQEL LAT activity, induced; molecular association, regulation cytoskeletal reorganization; transcription, induced; transcription, altered SLP76(INDUCES); GRB2(INDUCES); PLCG1(INDUCES); GADS(INDUCES) 10811803; 11046020; 20460647 40 4 54 NF-AT mediated transcription; Does not regulate integrin mediated adhesion.; association of LAT-rich vesicles with surface clusters of SLP76 +EGFR EGFR EC 2.7.10.1; KINASE; Kinase, protein; Membrane protein, integral; Oncoprotein; Protein kinase, TK; Protein kinase, tyrosine (receptor) P00533 1956 7p11.2 human K708-ub 1065311 QALLRILkETEFKKI protein degradation 17940017 1 4 0 +TERF2 TRF2 DNA repair, damage; DNA-binding Q15554 7014 16q22.1 human R67-me 10338214 RASRSSGrARRGRHE cell cycle regulation; cell growth, altered 19596784 1 0 0 +CTNNB1 CTNNB1 Actin-binding; Cell adhesion; Motility/polarity/chemotaxis; Nuclear receptor co-regulator; Oncoprotein; Transcription factor P35222 1499 3p22.1 human T472-p 3653236 ICALRHLtSRHQEAE Arm apoptosis, induced; transcription, inhibited 24117889 1 1 0 +CNR1 CNR1 GPCR, family 1; Membrane protein, integral; Membrane protein, multi-pass; Receptor, GPCR P21554 1268 6q15 human T467-p 22342301 TMSVSTDtSAEAL__ molecular association, regulation CRIP1(DISRUPTS); ARRB2(DISRUPTS) 27895162 2 0 0 +USP10 USP10 DEUBIQUITINASE; EC 3.4.19.12; Protease; RNA-binding; Ubiquitin conjugating system; Ubiquitin-specific protease Q14694 9100 16q24.1 human S337-p 12483200 ASGTLPVsQPKSWAS protein stabilization; ubiquitination; intracellular localization carcinogenesis, inhibited; cell growth, altered 20096447 1 0 0 regulates p53 homeostasis +GSK3A GSK3A EC 2.7.11.1; EC 2.7.11.26; KINASE; Kinase, protein; Protein kinase, CMGC; Protein kinase, Ser/Thr (non-receptor) P49840 2931 19q13.2 human S21-p 448584 SGRARTSsFAEPGGG protein degradation; ubiquitination; enzymatic activity, inhibited carcinogenesis, induced; cell growth, induced; apoptosis, induced; apoptosis, inhibited 11035810; 11520785; 11956225; 18701488; 21530327; 21868755; 24879152; 25714023; 37495110 156 24 277 +PARP1 PARP1 DNA repair, damage; EC 2.4.2.30; Nuclear envelope; Nuclear receptor co-regulator; Nucleolus; Transferase P09874 142 1q42.12 human K23-m1 1883588000 SGRASCKkCSESIPK DNA repair, induced 35847980 1 1 0 repair of stalled replication forks +PACSIN2 PACSIN2 Adaptor/scaffold; Motility/polarity/chemotaxis Q9UNF0 11252 22q13.2 human S372-p 3215997 EDEDDTGsTVSEKDD molecular association, regulation; receptor internalization, altered neural plasticity PICK1(DISRUPTS) 23918399 1 3 0 regulates AMPAR trafficking +DEK DEK DNA replication; DNA-binding; Histone-binding; Oncoprotein; RNA splicing P35659 7913 6p22.3 human S32-p 465616 MPGPREEsEEEEDED molecular association, regulation RNA splicing, altered U2AF1(INDUCES) 16809543 3 57 43 +Rho Rhodopsin GPCR, family 1; Membrane protein, integral; Membrane protein, multi-pass; Receptor, GPCR P15409 212541 6 E3|6 53.72 cM mouse S334-p 448677 PLGDDDAsATASKTE receptor inactivation, altered 11086991 8 6 0 Mutant rhodopsins had prolonged rate of recovery with increasing number of phosphorylation sites. +CTPS1 CTPS EC 6.3.4.2; Ligase; Motility/polarity/chemotaxis; Nucleotide Metabolism - pyrimidine P17812 1503 1p34.2 human S574-p 452258 YSDRSGSsSPDSEIT activity, inhibited 17681942 1 51 5 +CNOT7 CNOT7 EC 3.1.13.4; Transcription, coactivator/corepressor Q9UIV1 29883 8p22 human K206-ac 59117700 MKSCKNLkGGLQEVA CAF1 molecular association, regulation cell differentiation, inhibited; RNA stability, inhibited RNA(INDUCES) 27635759 1 1 0 +Syngap1 SynGAP GAP; GAP, Ras Q9QUH6 192117 20p12 rat S780-p 451015 MARGLNSsMDMARLP DUF3498 activity, induced 14970204 2 6 0 +ADAM17 TACE EC 3.4.24.86; Membrane protein, integral; Motility/polarity/chemotaxis; Protease P78536 6868 2p25.1 human S819-p 449039 QRQNRVDsKETEC__ enzymatic activity, induced 20188673 3 7 1 +Cdk5r1 CDK5R1 Protein kinase, regulatory subunit P61809 12569 11 B5|11 47.94 cM mouse S33-p 13421403 HYTAVQNsKNAKDKN protein processing 20200223 1 0 0 calpain-mediated cleavage +NCOA3 SRC-3 ACETYLTRANSFERASE; Acetyltransferase; EC 2.3.1.48; Motility/polarity/chemotaxis; Nuclear receptor co-regulator; Transcription, coactivator/corepressor Q9Y6Q9 8202 20q13.12 human S1062-p 4252805 DQLHTLLsNTDATGL Nuc_rec_co-act protein stabilization; molecular association, regulation carcinogenesis, induced; transcription, induced ATF-4(INDUCES); PSMA3(DISRUPTS) DNA(INDUCES) 18313384; 31975428 2 1 1 induces binding to promoters of genes in the purine pathway; some subset of these 8 residues +MYC Myc iso1 DNA-binding; Nucleolus; Oncoprotein; Transcription factor P01106-1 4609 8q24.21 human K323-ub 21179450 RKDYPAAkRVKLDSV Myc_N protein degradation carcinogenesis, inhibited; transcription, inhibited 35296795 1 1 0 +ITGB1BP1 ICAP1 Cell adhesion; Motility/polarity/chemotaxis O14713 9270 2p25.1 human S10-p 1872961000 RKGKKRHsSSSSQSS ICAP-1_inte_bdg intracellular localization 32005669 1 0 0 regulates localization of itself and of KRIT1 +Foxp2 FOXP2 C2H2-type zinc finger protein; DNA-binding P58463 114142 6|6 A1 mouse K673-sm 56423807 HIHSIHVkEEPVIAE intracellular localization cell growth, induced; cell differentiation, induced; transcription, inhibited 27009683 1 0 0 +BCL2 Bcl-2 Apoptosis; Autophagy; Membrane protein, integral; Oncoprotein P10415 596 18q21.33 human S87-p 448396 AAAGPALsPVPPVVH molecular association, regulation; protein stabilization; ubiquitination; protein conformation; activity, inhibited apoptosis, altered; apoptosis, induced; apoptosis, inhibited BAX(INDUCES); beclin 1(DISRUPTS); PIN1(INDUCES); p53(DISRUPTS) 10567572; 10669763; 11077443; 11495898; 12039864; 15703383; 16714293; 16738310; 17097560; 18570871; 19029119; 19336399; 23272207; 25826088; 34064109 22 1 0 +Eif2ak2 PKR EC 2.7.10.2; EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, Other; Protein kinase, Ser/Thr (non-receptor); Protein kinase, tyrosine (non-receptor); Translation Q03963 19106 17 E3|17 49.56 cM mouse T414-p 448089 SRTRRTGtLQYMSPE Pkinase apoptosis, induced; translation, inhibited 34647267 15 1 0 +ACE2 ACE2 EC 3.4.17.23; Membrane protein, integral; Protease Q9BYF1 59272 Xp22.2 human S787-p 1868161400 PYASIDIsKGENNPG transcription, induced 20484496 2 0 0 activation of ERK1/2 and upregulation of CCL2by SARS-CoV VLPs +EGFR EGFR EC 2.7.10.1; KINASE; Kinase, protein; Membrane protein, integral; Oncoprotein; Protein kinase, TK; Protein kinase, tyrosine (receptor) P00533 1956 7p11.2 human R224-m2 56856901 QQCSGRCrGKSPSDC Furin-like intracellular localization; protein conformation; enzymatic activity, induced cell growth, induced 26571401 1 1 0 +RBL1 Rb-like 1 Transcription, coactivator/corepressor; Tumor suppressor P28749 5933 20q11.23 human S640-p 451296 RRDMQPLsPISVHER cell growth, altered 11884610 3 24 10 +SLAMF7 SLAMF7 Immunoglobulin superfamily; Membrane protein, integral Q9NQ25 57823 1q23.3 human Y284-p 455053 HSGENTEyDTIPHTN intracellular localization; phosphorylation 25312647 1 2 14 Y284 is needed for tyrosine phosphorylation of SHIP-1 in response to SLAMF7 engagement +ITGB7 ITGB7 Cell adhesion; Membrane protein, integral; Motility/polarity/chemotaxis; Receptor, misc. P26010 3695 12q13.13 human T784-p 464648 LYKSAITtTINPRFQ Integrin_b_cyt molecular association, regulation FLNA(DISRUPTS) 16455489 1 0 0 based on glutamate mutant of threonine site +Eef2k EEF2K EC 2.7.11.20; KINASE; Kinase, protein; Protein kinase, Ser/Thr (non-receptor); Protein kinase, atypical; Translation P70531 25435 1q36 rat S499-p 455998 RLHLPRPsAVALEVQ phosphorylation; enzymatic activity, induced 11171059; 33191388 6 9 2 induces phosphorylation of EEf2 +SMAD1 SMAD1 DNA-binding; Transcription factor Q15797 4086 4q31.21 human S239-p 25546600 DPMTQDGsQPMDTNM activity, induced; molecular association, regulation DNA repair, induced; carcinogenesis, inhibited; apoptosis, induced; transcription, induced p53(INDUCES); PPPM1A(INDUCES) 22588298 1 0 0 +Med17 MED17 Nuclear receptor co-regulator; Transcription, coactivator/corepressor Q8VCD5 234959 9|9 A2 mouse S53-p 4765330 RIDFSQGsGSEEEEA activity, induced; intracellular localization transcription, induced 28223413 1 8 0 Induced FASN promoter activity, activation of lipogenic genes, MED17 recruitment to FASN promoter +CLOCK CLOCK ACETYLTRANSFERASE; Acetyltransferase; DNA-binding; EC 2.3.1.48; Transcription factor O15516 9575 4q12 human S106-p 1881001400 DWKPTFLsNEEFTQL molecular association, regulation; intracellular localization carcinogenesis, induced; cell growth, induced; apoptosis, inhibited; transcription, inhibited Exportin-1(INDUCES); PRPS1(INDUCES); PRPS2(INDUCES); BMAL1(DISRUPTS) 36646788 1 1 0 binding to PRPS1/2 inhibits HSC70 binding to PRPS1/2 +RAC1 RAC1 G protein; G protein, monomeric; G protein, monomeric, Rho; Motility/polarity/chemotaxis P63000 5879 7p22.1 human K166-ub 12108617 ALTQRGLkTVFDEAI Ras protein degradation cell motility, inhibited 23512198 1 9 2 +Des desmin Cytoskeletal; Motility/polarity/chemotaxis P31001 13346 1 C4|1 38.85 cM mouse S8-p 478271 MSQAYSSsQRVSSYR transcription, altered; cell growth, altered 17381546 1 0 0 important for cardiomyogenesis +Stat5a STAT5A DNA-binding; Motility/polarity/chemotaxis; Oncoprotein; Transcription factor P42230 20850 11 D|11 63.77 cM mouse S725-p 448749 TYMDQAPsPVVCPQP activity, induced; molecular association, regulation; activity, inhibited; phosphorylation carcinogenesis, altered; cell growth, induced DNA(DISRUPTS) 10744710; 12091337; 12529425; 20508164; 24263804 19 1 0 +VCL Vinculin iso2 Cell adhesion; Cytoskeletal; Motility/polarity/chemotaxis P18206-2 7414 10q22.2 human Y1065-p 454003 WVRKTPWyQ______ Vinculin activity, induced; molecular association, regulation; protein conformation cell adhesion, altered; cytoskeletal reorganization BSG(INDUCES); talin 1(INDUCES) 20678470; 24338477; 25033086 9 1 22 +Dnm2 DYN2 EC 3.6.5.5; Hydrolase; Microtubule-binding; Motility/polarity/chemotaxis; Vesicle P39054 13430 9 A3|9 7.79 cM mouse S764-p 3191449 LQNTSGHsPTPQRRP enzymatic activity, inhibited signaling pathway regulation 32510172 5 9 0 phosphorylation of this site inhibits Fc gamma R-mediated phagocytosis +MFF MFF Membrane protein, integral; Mitochondrial Q9GZY8 56947 2q36.3 human K302-ub 41529300 SLRRQIIkLNRRLQL Miff protein degradation 31112535 2 1 0 PARK2 mediated lysosomal degradation of MFF +LRP2 LRP2 Membrane protein, integral; Motility/polarity/chemotaxis; Receptor, misc. P98164 4036 2q31.1 human T4478-p 767906 SENGNGVtFRSGADL receptor internalization, altered; receptor recycling, altered 17555532 1 0 0 +MAFA MAFA DNA-binding; Oncoprotein; Transcription factor; Tumor suppressor Q8NHW3 389692 8q24.3 human T53-p 1320402 PPGSLSStPLSTPCS protein degradation; molecular association, regulation; ubiquitination carcinogenesis, induced; transcription, induced PCAF(INDUCES) 18042454 4 1 0 +CIITA CIITA DNA-binding; EC 2.7.11.1; KINASE; Protein kinase, Ser/Thr (non-receptor); Transcription, coactivator/corepressor P33076 4261 16p13.13 human S286-p 2902204 TSPDRPGsTSPFAPS intracellular localization transcription, altered 15210796 1 0 0 +PRKAA1 AMPKA1 Autophagy; EC 2.7.11.1; EC 2.7.11.26; EC 2.7.11.27; EC 2.7.11.31; KINASE; Kinase, protein; Protein kinase, CAMK; Protein kinase, Ser/Thr (non-receptor) Q13131 5562 5p13.1 human T490-p 3195170 EAKSGTAtPQRSGSV AdenylateSensor protein conformation; phosphorylation transcription, induced; autophagy, inhibited; translation, induced 23623684 1 32 56 induces phosphorylation of T482 and S486 and inhibits phosphorylation at T172 and of ACC and Raptor +PIP5K1C PIP5K1C Carbohydrate Metabolism - inositol phosphate; EC 2.7.1.68; Kinase, lipid; Motility/polarity/chemotaxis O60331 23396 19p13.3 human S453-p 15721933 KNSSLKSsPSKKGRG enzymatic activity, inhibited 30040488 1 3 0 induces cell invasion, decreases fibronectin secretion +SPP1 osteopontin Secreted; Secreted, signal peptide P10451 6696 4q22.1 human S123-p 455738 DSHQSDEsHHSDESD Osteopontin molecular association, regulation; activity, inhibited Other(INDUCES) 19775205 1 5 0 peptide with phosphorylated S117, S120, S123, S126 and S129 has increased binding to hydroxyapatite, and inhibits bone mineralization in vivo and in vitro +RANBP2 RANBP2 Adaptor/scaffold; EC 5.2.1.8; EC 6.3.2.-; Ligase; Nuclear export; Nucleoporin; SUMO LIGASE; SUMO conjugating system; SUMO ligase P49792 5903 2q13 human T2153-p 3191215 LLDIPLQtPHKLVDT molecular association, regulation; intracellular localization BICD2(INDUCES) 26051540 1 25 19 targets BicD2 to the NE of RGP cells to induce apical nuclear migration +PRKDC DNAPK DNA repair, damage; EC 2.7.11.1; KINASE; Kinase, protein; Nucleolus; Protein kinase, Ser/Thr (non-receptor); Protein kinase, atypical P78527 5591 8q11.21 human T2609-p 448710 LTPMFVEtQASQGTL DNAPKcs_CC5 molecular association, regulation; intracellular localization; protein conformation; enzymatic activity, induced cell cycle regulation; carcinogenesis, induced; DNA repair, induced; chromatin organization, altered; DNA repair, altered; cell growth, altered SLC25A5(DISRUPTS) DNA(DISRUPTS) 12231622; 17189255; 18037521; 19244120; 20406977; 24687855; 24844881; 31980741; 32868446; 34249431; 35974014; 36727301 36 8 22 +CRMP1 CRMP-1 Cell development/differentiation; Cytoskeletal; Hydrolase Q14194 1400 4p16.2 human T101-p 11539300 RAALVGGtTMIIDHV Amidohydro_1 cell cycle regulation 19799413 1 1 0 +HMGN1 HMGN1 DNA-binding; Nuclear receptor co-regulator P05114 3150 21q22.2 human S21-p 454111 KEEPKRRsARLSAKP HMG14_17 molecular association, regulation; intracellular localization transcription, altered 14-3-3 zeta(INDUCES); SRF(DISRUPTS) DNA(DISRUPTS) 10739259; 12215538; 17938209 4 9 14 +Map3k4 MEKK4 EC 2.7.11.25; KINASE; Kinase, protein; Protein kinase, STE; Protein kinase, Ser/Thr (non-receptor) O08648 26407 17 8.42 cM|17 A1 mouse S1241-p 4695872 RSLSRHSsPTEERDE MEKK4_N molecular association, regulation; enzymatic activity, induced GADD45A(INDUCES) 27358404 1 16 1 +NDRG1 NDRG1 Cell development/differentiation; Vesicle Q92597 10397 8q24.22 human T346-p 454245 GTRSRSHtSEGTRSR phosphorylation carcinogenesis, induced; carcinogenesis, inhibited; carcinogenesis, altered; cell differentiation, induced; cell growth, induced; apoptosis, inhibited; signaling pathway regulation 20416281; 21719465; 27451907; 33003561; 37298315 26 13 246 +MAPT Tau iso3 ACETYLTRANSFERASE; Acetyltransferase; Cytoskeletal P10636-3 4137 17q21.31 human S105-p 447927 GDRSGYSsPGSPGTP molecular association, regulation cytoskeletal reorganization 10747907 91 33 33 regulates association with membrane +PKP3 plakophilin 3 Cell adhesion Q9Y446 11187 11p15.5 human S285-p 4782043 APSVRSLsLSLADSG molecular association, regulation; intracellular localization cell adhesion, induced; cell motility, inhibited 14-3-3 sigma(INDUCES) 24124604; 29678907 2 8 0 strong plasma membrane association with or without 14-3-3 sigma overexpression in WT cells; Mutants unable to associate with 14-3-3 sigma, display decreased adhesion and increased motility. +LIFR LIFR Membrane protein, integral; Receptor, cytokine P42702 3977 5p13.1 human S887-p 4707125 KALQFQKsVCEGSSA protein conformation 28122243 1 6 2 ESC pluripotency in vivo +Htr2a 5-HT(2A) GPCR, family 1; Membrane protein, integral; Membrane protein, multi-pass; Receptor, GPCR P14842 29595 15q11 rat S314-p 6057801 AGRRTMQsISNEQKA 7tm_1 receptor desensitization, altered; activity, inhibited 19103592 1 0 0 +Myod1 MyoD DNA-binding; RNA splicing; Transcription factor P10085 17927 7 B3|7 30.03 cM mouse S237-p 3188104 YSEAAREsRPGKSAA Myf5 activity, induced transcription, altered 10838091 1 0 0 +PHLPP1 PHLPP EC 3.1.3.16; PHOSPHATASE; Protein phosphatase, Ser/Thr (non-receptor); Tumor suppressor O60346 23239 18q21.33 human S336-p 27454806 FVGGPVSsPRAPRPV cell cycle regulation 33397691 1 7 0 +POLI POLI DNA repair, damage; EC 2.7.7.7; Transferase Q9UNA4 11201 18q21.2 human K729-ub 50771309 KELLAEWkRAGSDFH protein degradation 26370087 1 2 0 +MUC1 MUC1 Actin-binding; Cell adhesion; Membrane protein, integral; Motility/polarity/chemotaxis; Nuclear receptor co-regulator; Tumor suppressor P15941 4582 1q22 human Y1243-p 454879 NGGSSLSyTNPAVAA molecular association, regulation; intracellular localization; receptor internalization, altered GRB2(INDUCES); Abl(INDUCES) 15471854; 16888623 3 5 79 MUC1 blocks binding of Abl to 14-3-3 proteins, Abl phosphorylates MUC1 on Y1243; Y1203 and Y1243 are both required for efficient mucin 1 endocytosis +Lcp2 SLP76 Adaptor/scaffold Q60787 16822 11|11 A4 mouse T341-p 15415128 LPSMSSNtFPSRSVQ molecular association, regulation 14-3-3 zeta(INDUCES) 35061003 0 3 18 +DAXX DAXX Apoptosis; Nuclear receptor co-regulator; Nucleolus; Transcription, coactivator/corepressor Q9UER7 1616 6p21.32 human S176-p 3214944 TNAENTAsQSPRTRG protein stabilization; ubiquitination apoptosis, induced 19789334; 19789335 2 0 0 required for TNF alpha -dependent accumulation of Daxx in cells ; phosphorylation induces K63-linked polyubiquitination of DAXX at K122 +Nufip2 82-FIP RNA processing; RNA-binding; Translation Q5F2E7 68564 11|11 B5 mouse S114-p 3204054 ISLKSLSsDEATNPI NUFIP2 carcinogenesis, induced; translation, induced 33972660 1 13 0 +H2BC3 H2B DNA-binding P33778 3018 6p22.2 human K5-ac 458955 ___PEPSkSAPAPKK Histone cell cycle regulation; carcinogenesis, induced; chromatin organization, altered; transcription, induced; transcription, altered 16283522; 19883641 7 7 115 +Id2 ID2 DNA-binding; Transcription, coactivator/corepressor P41136 15902 12 A1.3|12 8.57 cM mouse S5-p 451265 ___MKAFsPVRSVRK intracellular localization cell cycle regulation; apoptosis, altered; cell growth, altered 19609365 4 6 0 Phosphorylated Id2 is localized to the nucleus. +Nfe2l2 NRF2 DNA-binding; Transcription factor Q60795 18024 2 C3|2 44.75 cM mouse S550-p 10292703 HLLKRRLsTLYLEVF bZIP_Maf intracellular localization transcription, induced 27161318 3 2 0 nuclear accumulation +LRP6 LRP6 Membrane protein, integral; Receptor, misc. O75581 4040 12p13.2 human T1548-p 21009100 YAPSRRMtSVATAKG molecular association, regulation; intracellular localization G-alpha(s)(INDUCES) 21406690 1 0 0 mutation impairs G-alpha-s movement to plasma membrane +Hnf4a HNF4 alpha DNA-binding; Nuclear receptor; Transcription factor P22449 25735 3q42 rat S87-p 478421 CKGFFRRsVRKNHMY zf-C4 protein degradation; intracellular localization transcription, altered DNA(DISRUPTS) 17389749 1 0 0 S87D mutation impairs nuclear localization. +NABP2 OBFC2B Cell cycle regulation; DNA repair, damage Q9BQ15 79035 12q13.3 human K94-sm 1877008702 GRGGDLQkIGEFCMV tRNA_anti-codon protein stabilization; molecular association, regulation apoptosis, induced NBS1(INDUCES) 32576812 1 0 0 recruitment of the MRN complex to DSB sites, sumoylation enhances the sensitivity of cancer cells to DNA damage agents +IRAK1 IRAK1 EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, Ser/Thr (non-receptor); Protein kinase, TKL P51617 3654 Xq28 human T387-p 447721 RTQTVRGtLAYLPEE Pkinase molecular association, regulation; phosphorylation; enzymatic activity, induced signaling pathway regulation TRAF6(INDUCES) 14625308; 31511642 5 1 0 induces MAPK and NF-kB signaling pathways by inducing phosphorylation of JNK and ERK +KCNJ1 ROMK Channel, potassium; Membrane protein, integral; Membrane protein, multi-pass P48048 3758 11q24.3 human S44-p 449605 RQRARLVsKDGRCNI IRK protein processing; activity, inhibited 15987778; 18571730 9 0 0 +Tdg TDG DNA repair, damage; EC 3.2.2.29; Hydrolase; Nuclear receptor co-regulator P56581 21665 10 C1|10 39.72 cM mouse K70-ac 458993 EPAPEAPkRRKRKPR molecular association, regulation; acetylation DNA repair, induced; chromatin organization, altered; transcription, induced APE1(DISRUPTS) 11864601 1 0 0 histone acetylation +CENPQ CENPQ Q7L2Z9 55166 6p12.3 human S255-p 40245504 SSQMKSMsTFIEEAY CENP-Q molecular association, regulation; intracellular localization DNA(DISRUPTS) 25670858 1 1 0 CENPQ phosphorylation promotes the delocalization of the PBIP1-CENPQ complex from kinetochores +RAD52 RAD52 DNA repair, damage P43351 5893 12p13.33 human K133-ac 971232903 YGVSEGLkSKALSLE Rad52_Rad22 molecular association, regulation; intracellular localization DNA repair, induced RFA2(INDUCES); RPA3(INDUCES); RAD51(INDUCES); RPA1(INDUCES) 29590107 1 1 0 accumulation of RAD52 at DSB sites +Prkaa1 AMPKA1 Autophagy; EC 2.7.11.1; EC 2.7.11.26; EC 2.7.11.27; EC 2.7.11.31; KINASE; Kinase, protein; Protein kinase, CAMK; Protein kinase, Ser/Thr (non-receptor) Q5EG47 105787 15|15 A1 mouse S172-p 15407586 KIADFGLsNMMSDGE Pkinase enzymatic activity, induced 33400924 8 1 4 +Wasl N-WASP Adaptor/scaffold; Motility/polarity/chemotaxis O08816 682507 4q22 rat T202-p 23003803 LTKADIGtPSNFQHI PBD molecular association, regulation; protein conformation cytoskeletal reorganization 22250195 1 1 0 inhibits actin polymerization in vitro; inhibits the filopodia promoting activity of N-WASP +Kcnj3 GIRK1 Channel, potassium; Membrane protein, integral; Membrane protein, multi-pass P63251 50599 3q21 rat Y12-p 457610 RRKFGDDyQVVTTSS activity, inhibited 10833508 5 0 0 +Ehmt2 EHMT2 Amino Acid Metabolism - lysine degradation; EC 2.1.1.43; METHYLTRANSFERASE; Methyltransferase; Methyltransferase, protein lysine Q9Z148 110147 17 B1|17 18.45 cM mouse K167-m2 1458625 IVLGHATkSFPSSPS molecular association, regulation HP1 alpha(INDUCES); CBX3(INDUCES) 17707231 1 2 0 +TSC2 TSC2 Cell cycle regulation; GAP; GAP, misc.; Nuclear receptor co-regulator; Tumor suppressor P49815 7249 16p13.3 human T1462-p 448546 GLRPRGYtISDSAPS activity, inhibited; phosphorylation cell cycle regulation; carcinogenesis, induced; carcinogenesis, inhibited; apoptosis, induced; signaling pathway regulation; transcription, altered; autophagy, induced; cell growth, induced; apoptosis, inhibited 15342917; 16702951; 21893193; 23142783; 27451907; 33273660; 35154579; 35670018; 37160904 64 14 48 regulates mTOR and downstream signaling +JAK2 JAK2 EC 2.7.10.2; KINASE; Kinase, protein; Oncoprotein; Protein kinase, TK; Protein kinase, tyrosine (non-receptor) O60674 3717 9p24.1 human K970-ub 1873147100 GMEYLGTkRYIHRDL PK_Tyr_Ser-Thr phosphorylation; enzymatic activity, induced transcription, induced; signaling pathway regulation 28676638 1 0 0 JAK2/STAT5 signal axis +PKM PKM Carbohydrate Metabolism - glycolysis and gluconeogenesis; Carbohydrate Metabolism - pyruvate; EC 2.7.1.40; KINASE; Kinase, other; Mitochondrial; Nucleotide Metabolism - purine P14618 5315 15q23 human S37-p 476070 MCRLDIDsPPITARN activity, induced; molecular association, regulation; intracellular localization; enzymatic activity, altered; phosphorylation carcinogenesis, induced; cell motility, induced; cell growth, induced; apoptosis, inhibited; transcription, induced; transcription, altered; transcription, inhibited CTNNB1(DISRUPTS); PKM(INDUCES); ERK2(INDUCES); ERK1(INDUCES); PKM(DISRUPTS); PIN1(INDUCES); PPP1R26(INDUCES) Other(INDUCES) 23178880; 25446258; 27323830; 27485204; 29229835; 32078667; 32989054; 34185676; 34966685; 35292107; 35790734 17 62 6 +PYCARD PYCARD Adaptor/scaffold; Tumor suppressor Q9ULZ3 29108 16p11.2 human Y137-p 3920078 EWLLDALyGKVLTDE CARD activity, induced signaling pathway regulation 31333677 1 0 1 important for NLRP2 inflammasome complex formation and function +FOXO1 FOXO1A DNA-binding; Nuclear receptor co-regulator; Oncoprotein; Transcription factor Q12778 2308 13q14.11 human S394-p 12607401 LTVSTQSsPGTMMQQ intracellular localization transcription, altered 20061393 1 0 0 multiple site mutant (8A) +KCNMB4 KCNMB4 Channel, potassium; Membrane protein, integral; Membrane protein, multi-pass Q86W47 27345 12q15 human T11-p 451271 LRVAYEYtEAEDKSI CaKB activity, inhibited 11790768 1 0 0 regulates slowpoke K(+) channel kinetics +CLDN4 Claudin-4 Cytoskeletal; Membrane protein, integral; Membrane protein, multi-pass O14493 1364 7q11.23 human S194-p 4199301 PRTDKPYsAKYSAAR intracellular localization cytoskeletal reorganization 18786529 2 1 1 +KIF2A KIF2A Microtubule-binding; Motor O00139 3796 5q12.1 human T554-p 40240801 ANRVKELtVDPTAAG intracellular localization cytoskeletal reorganization 25660017 1 0 0 similar temporal and spatial localization; microtubule depolymerization, disassemble primary cilia +MAPT Tau iso8 ACETYLTRANSFERASE; Acetyltransferase; Cytoskeletal P10636-8 4137 17q21.31 human K281-ac 1873575602 KVQIINKkLDLSNVQ Tubulin-binding intracellular localization; phosphorylation cytoskeletal reorganization 27356871; 28855586 5 2 0 +CDC25C CDC25C EC 3.1.3.48; Motility/polarity/chemotaxis; PHOSPHATASE; Protein phosphatase, dual-specificity P30307 995 5q31.2 human S263-p 486328 LCLKKTVsLCDITIT M-inducer_phosp intracellular localization 17662724 1 7 3 negatively regulates translocation from cytoplasm to nucleus +FOS Fos DNA-binding; Motility/polarity/chemotaxis; Oncoprotein; Transcription factor P01100 2353 14q24.3 human S32-p 470080 DSLSYYHsPADSFSS protein stabilization; molecular association, regulation UBR1(DISRUPTS) 17018293 4 0 0 +NAT10 ALP ACETYLTRANSFERASE; Acetyltransferase; EC 2.3.1.-; Nucleolus Q9H0A0 55226 11p13 human K426-ac 466140 TGRSLSLkLIQQLRQ Helicase_RecD enzymatic activity, induced transcription, induced 27993683 1 6 18 +Dab1 DAB1 Adaptor/scaffold P97318 13131 4 C6|4 47.79 cM mouse Y198-p 447629 EDVEDPVyQYIVFEA molecular association, regulation; intracellular localization neural plasticity; cell differentiation, induced; cell motility, altered; cytoskeletal reorganization Src(INDUCES); SOCS1(INDUCES); PIK3R1(INDUCES) 14517291; 19796633; 22586277 11 1 0 alternatively spliced variants +Hnf4a HNF4 alpha DNA-binding; Nuclear receptor; Transcription factor P49698 15378 2 H3|2 84.32 cM mouse S313-p 449926 GKIKRLRsQVQVSLE Hormone_recep carcinogenesis, inhibited; cell differentiation, induced 34616001 5 3 0 +Golga2 GM130 Cytoskeletal Q62839 64528 3p12 rat S37-p 454438 REYQQKNsPGVPAGA cell cycle regulation 20699666 4 18 1 +KAT2B PCAF ACETYLTRANSFERASE; Acetyltransferase; EC 2.3.1.48; Nuclear receptor co-regulator Q92831 8850 3p24.3 human K428-ac 458985 LEANPGEkRKMTDSH enzymatic activity, induced 12888487 1 0 0 in vitro +Zc3hav1 ZAP RNA-binding; Transferase Q8K3Y6 252832 4q22 rat S262-p 1870336230 HNSLEFLsPVVSPLG activity, induced 22514281 1 0 0 +CIITA CIITA DNA-binding; EC 2.7.11.1; KINASE; Protein kinase, Ser/Thr (non-receptor); Transcription, coactivator/corepressor P33076 4261 16p13.13 human K144-ac 458926 EVGQKSQkRPFPEEL intracellular localization transcription, induced 11046145 1 0 0 nuclear localization +RHOA RHOA G protein; G protein, monomeric; G protein, monomeric, Rho; Motility/polarity/chemotaxis; Oncoprotein P61586 387 3p21.31 human S188-p 449035 ARRGKKKsGCLVL__ protein stabilization; molecular association, regulation; enzymatic activity, inhibited; intracellular localization; activity, inhibited; phosphorylation cell differentiation, induced; cell motility, induced; apoptosis, inhibited; cytoskeletal reorganization; endocytosis, inhibited KRas iso2(INDUCES); PKN1(INDUCES); RhoGDI alpha(INDUCES); ROCK1(DISRUPTS); Diaphanous-1(INDUCES) 11162591; 12654918; 15890975; 16109481; 20591975; 21572420; 34088899; 34497151; 34551282 17 0 0 induces AKT phosphorylation, inhibits MLC phosphorylation +ANAPC1 APC1 Cell cycle regulation; Ubiquitin conjugating system Q9H1A4 64682 2q13 human S373-p 455826 VQRFNISsHNQSPKR activity, induced 27120157 2 5 0 +Rorc RORC iso2 DNA-binding; Nuclear receptor; Transcription factor P51450-2 19885 3|3 F2.1 mouse S484-p 139835701 PLYKELFsTDVESPE cell differentiation, inhibited; transcription, inhibited 28667162 1 1 0 +MAP3K5 ASK1 EC 2.7.11.25; KINASE; Kinase, protein; Protein kinase, STE; Protein kinase, Ser/Thr (non-receptor) Q99683 4217 6q23.3 human S83-p 447735 ATRGRGSsVGGGSRR enzymatic activity, inhibited; enzymatic activity, induced; phosphorylation carcinogenesis, induced; apoptosis, altered; apoptosis, inhibited; signaling pathway regulation; transcription, altered 11154276; 12697749; 14500571; 15782121; 16532036; 18794113; 19749799; 23608533; 26912789; 30205811 16 2 6 regulates ASK1-MAPK pathway +COIL coilin Oxidoreductase P38432 8161 17q22 human S202-p 10336301 KKAKNPKsPKVQAVK Coilin_N intracellular localization 9013710 1 0 0 S202A mutant is localized to nucloplasmic coiled bodies, while S202D is localized to intranucleolar domains. Phosphorylation may regulate SnRNP-nucleolar interactions. +SRC Src EC 2.7.10.2; KINASE; Kinase, protein; Oncoprotein; Protein kinase, TK; Protein kinase, tyrosine (non-receptor) P00523 396442 chicken S12-p 448230 KSKPKDPsQRRRSLE molecular association, regulation; phosphorylation cell growth, altered PKCD(DISRUPTS) 2474754; 9148947 5 1 1 Mutation of S16 increases phosphorylation at S12 +BAD BAD Apoptosis Q92934 572 11q13.1 human S75-p 447860 EIRSRHSsYPAGTED Bcl-2_BAD activity, induced; molecular association, regulation; activity, inhibited carcinogenesis, induced; apoptosis, altered; apoptosis, induced; transcription, altered; apoptosis, inhibited; cell adhesion, altered; transcription, inhibited; cell growth, altered 14-3-3 beta(INDUCES); Bcl-2(DISRUPTS); Bcl-xL(DISRUPTS) 10558990; 10611223; 10976111; 11085518; 12897059; 12970779; 14678993; 15121878; 15226424; 15972258; 17670745; 18246127; 18794113; 19154409; 20566643; 21187157; 21419810; 22096607; 25681438; 26366732; 33755959; 34138895 129 22 172 +Cav3 caveolin-3 Cell development/differentiation; Dystrophin complex; Extracellular matrix; Motility/polarity/chemotaxis P51638 29161 4q41 rat K38-sm 25087000 NINEDIVkVDFEDVI Caveolin receptor desensitization, altered 21362625 1 0 0 +Lpin1 LPIN1 EC 3.1.3.4; Phosphatase, lipid Q91ZP3 14245 12 A1.1|12 7.9 cM mouse S483-p 471356 VGGSGIDsGVESTSD molecular association, regulation BTRC(INDUCES) 28049764 2 9 0 +HSP90AA1 HSP90A Chaperone; Heat shock protein P07900 3320 14q32.31 human Y38-p 15229603 SLIINTFySNKEIFL molecular association, regulation apoptosis, inhibited Src(INDUCES); AHSA1(INDUCES); RAF1(INDUCES); HER2(INDUCES) 20159553 1 0 33 interaction with HSP90A client proteins; Silencing of Wee1 sensitizes cells to apoptosis induced by HSP90A inhibitor. +SOX11 SOX11 DNA-binding; Transcription factor P35716 6664 2p25.2 human K91-sm 1881173700 GKRWKMLkDSEKIPF sumoylation cell growth, induced 33441400 1 0 0 in vitro and in vivo K91A mutant induces RGC (retinal ganglion cell) cell death and optic nerve regeneration +MYC Myc DNA-binding; Nucleolus; Oncoprotein; Transcription factor P01106 4609 8q24.21 human T415-p 450962 VVILKKAtAYILSVQ HLH molecular association, regulation carcinogenesis, inhibited; cell growth, inhibited; cell differentiation, induced; transcription, induced MAX(DISRUPTS) DNA(INDUCES); DNA(DISRUPTS) 22020439; 25326649; 26678338 6 0 0 repression of YAP/TAZ activity +NCOA1 SRC-1 ACETYLTRANSFERASE; Acetyltransferase; DNA-binding; EC 2.3.1.48; Nuclear receptor co-regulator; Oncoprotein; Transcription, coactivator/corepressor Q15788 8648 2p23.3 human K774-sm 2407404 SLDDVKVkVEKKEQM intracellular localization transcription, induced PR(INDUCES) 12529333 1 0 0 +SSBP3 SSBP3 Cell cycle regulation; DNA-binding; Transcription regulation Q9BWW4 23648 1p32.3 human Y25-p 1806901 EKLALYVyEYLLHVG activity, induced; intracellular localization transcription, induced 18080319 1 0 0 +MAPT Tau iso8 ACETYLTRANSFERASE; Acetyltransferase; Cytoskeletal P10636-8 4137 17q21.31 human K340-sm 3829800 GGGQVEVkSEKLDFK Tubulin-binding protein stabilization; ubiquitination; phosphorylation 25378699 2 0 0 induces phosphorylation of itself at multiple sites and inhibits its ubiquitination +GMNN Geminin Cell cycle regulation; Motility/polarity/chemotaxis O75496 51053 6p22.3 human T203-p 475945 EGTVSSStDAKPCI_ apoptosis, altered 17261582 1 0 0 regulates geminin cleavage by caspase-3 +PPARG PPAR-gamma DNA-binding; Nuclear receptor; Transcription factor P37231 5468 3p25.2 human K107-sm 3617602 QEYQSAIkVEPASPP PPARgamma_N protein degradation cell differentiation, inhibited; carcinogenesis, inhibited; cell growth, inhibited; transcription, induced; transcription, altered; transcription, inhibited 15229330; 15507114; 25409419; 26244663; 29137280 15 0 0 transcription of a subset of PPAR-gamma target genes involved in lipid metabolism +IGF1R IGF1R EC 2.7.10.1; KINASE; Kinase, protein; Membrane protein, integral; Protein kinase, TK; Protein kinase, tyrosine (receptor) P08069 3480 15q26.3 human Y980-p 448390 YASVNPEyFSAADVY activity, induced; phosphorylation cell cycle regulation; cell differentiation, altered; apoptosis, altered; cell growth, altered 10746631; 10786694; 7834637 8 0 7 +PALLD palladin Cytoskeletal; Motility/polarity/chemotaxis Q8WX93 23022 4q32.3 human S688-p 18013438 APRSAPPsPPFPPPP molecular association, regulation cell motility, inhibited Abl(DISRUPTS) 22216253 1 6 0 +H4-16 H4 DNA-binding NP_001139343 530773 cow K16-ac 458960 GLGKGGAkRHRKVLR methylation cell cycle regulation 18698155 106 26 531 complex relationship of acetylation and methylation of CpG dinucleotides on DNA, during development of gametogenesis and embryogenesis +MAP3K20 ZAK EC 2.7.11.25; KINASE; Kinase, protein; Protein kinase, Ser/Thr (non-receptor); Protein kinase, TKL Q9NYL2 51776 2q31.1 human T162-p 455378 SRFHNHTtHMSLVGT PK_Tyr_Ser-Thr enzymatic activity, induced 15342622 1 0 0 +NFATC4 NFAT3 DNA-binding; Transcription factor Q14934 4776 14q12 human S259-p 31859079 APGPTPAsPRPASPC cell growth, induced; transcription, induced 27893713 1 1 0 +TPPP TPPP Cytoskeletal O94811 11076 5p15.33 human S107-p 31094519 FSKIKGKsCRTITFE p25-alpha acetylation; phosphorylation transcription, induced 23727580 1 0 0 decreases B-Catennin phosphorylation and acetylation and induces its expression +SPDEF SPDEF DNA-binding; Motility/polarity/chemotaxis; Nuclear receptor co-regulator; Transcription factor O95238 25803 6p21.31 human S243-p 54165902 TDSEVDSsCSGQPIH protein degradation cell motility, induced 26885618 1 0 0 enhances migration and invasion of prostate cancer cells +Nfil3 E4BP4 DNA-binding; Transcription factor O08750 18030 13 B1|13 27.68 cM mouse S301-p 470506 VPKGPIHsPVELQRV Vert_IL3-reg_TF transcription, inhibited 29311361 1 29 13 NK cell production inhibited +TP53 p53 Activator; DNA-binding; Motility/polarity/chemotaxis; Nuclear receptor co-regulator; Transcription factor; Tumor suppressor P04637 7157 17p13.1 human K373-ne 12067101 SSHLKSKkGQSTSRH transcription, inhibited 15242646 1 0 0 +Crebbp CBP ACETYLTRANSFERASE; Acetyltransferase; DNA-binding; EC 2.3.1.48; Motility/polarity/chemotaxis; Nuclear receptor co-regulator; Transcription, coactivator/corepressor P45481 12914 16 A1|16 2.4 cM mouse K1596-ac 461371 KNNKKTNkNKSSISR HAT_KAT11 acetylation 28630323 1 6 255 autoacetylation of CBP K1596 (autoregulatory loop (AL) of CBP) has a negative regulatory effect on acetylation of H3K27 +NFE2L2 NRF2 DNA-binding; Transcription factor Q16236 4780 2q31.2 human K508-ac 7106327 IRRRGKNkVAAQNCR bZIP_Maf molecular association, regulation transcription, induced DNA(INDUCES) 19273602 1 1 0 +LGALS3 galectin-3 Cell surface; Extracellular matrix; Motility/polarity/chemotaxis P17931 3958 14q22.3 human S6-p 450131 __MADNFsLHDALSG molecular association, regulation; intracellular localization; protein conformation cell cycle regulation; apoptosis, inhibited MUC1(DISRUPTS); LAMA1(DISRUPTS) 10961987; 11724777; 15121858; 24269589; 26911284 8 2 0 Expression of S5 mutants of galectin-3 failed to protect cells from cisplatin-induced death and poly(ADP-ribose) polymerase from degradation when compared with wild type galectin-3.; may allosterically influence carbohydrate binding to the S-face; little effect on interactions between the NT and CRD F-face; Phosphorylation of S6 and S12 In N-terminal promotes association with carbohydrate recognition domain (CRD), while phosphorylation of Y107 and Y118 attenuates this interaction. +PCGF1 PCGF1 EC 6.3.2.-; Ubiquitin conjugating system Q9BSM1 84759 2p13.1 human Y109-p 2897401 RVMQDIVyKLVPGLQ transcription, inhibited 15620699 1 0 0 +STK38 NDR1 EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, AGC; Protein kinase, Ser/Thr (non-receptor) Q15208 11329 6p21.31 human S10-p 22553319 MTGSTPCsSMSNHTK enzymatic activity, inhibited; phosphorylation signaling pathway regulation 22142472 1 0 0 primes phosphorylation at S6 and T7, induces JNK phosphorylation, regulates cell death through JNK signaling +RAP1GAP RAP1GAP GAP; GAP, Ras; Motility/polarity/chemotaxis P47736 5909 1p36.12 human S525-p 450258 AGQKTPDsGHVSQEP protein degradation; molecular association, regulation; ubiquitination cell growth, induced BTRC(INDUCES) 14660640; 25329897 2 1 0 Rap1GAP degradation is required for cell proliferation. +Pebp1 RKIP Lipid-binding; Protein kinase, regulatory subunit P31044 29542 12q16 rat S52-p 3189664 QVMNRPSsISWDGLD PBP phosphorylation 35696587 2 35 11 inhibits phosphorylation at S51 +Csf3r GCSFR Membrane protein, integral; Receptor, cytokine P40223 12986 4 D2.2|4 59.77 cM mouse Y788-p 449311 PTPSPKSyENIWFHS activity, induced; phosphorylation 7489718; 9032244 5 0 0 JNK activation and SHC phosphorylation; Mutation of Y788 abolished the ability of the receptor to stimulate tyrosine phosphorylation of a cellular protein with an Mr of 54 kDa. +DPYSL2 CRMP-2 Microtubule-binding; Motility/polarity/chemotaxis Q16555 1808 8p21.2 human K374-sm 31094501 DKAVVTGkMDENQFV Amidohydro_1 receptor internalization, induced; intracellular localization 33478555 6 0 0 Numb, Nedd4-2 and Eps15 compex is necessary for non-SUMOylated CRMP2-mediated internalization of sodium channels in vivo +Rbl2 Rb-like 2 Transcription, coactivator/corepressor; Tumor suppressor Q64700 19651 8 C4|8 44.25 cM mouse K128-ac 15207810 SLIEFFNkMKKWEDM DUF3452 phosphorylation 23029429 2 1 0 enhances phosphorylation of Rb-like2 +EGFR EGFR EC 2.7.10.1; KINASE; Kinase, protein; Membrane protein, integral; Oncoprotein; Protein kinase, TK; Protein kinase, tyrosine (receptor) P00533 1956 7p11.2 human Y1016-p 448055 DVVDADEyLIPQQGF activity, induced; molecular association, regulation; receptor internalization, altered; intracellular localization; protein conformation; phosphorylation; enzymatic activity, induced endocytosis, altered; carcinogenesis, inhibited; cell motility, altered; cell adhesion, altered; signaling pathway regulation SOS1(INDUCES); RASA1(INDUCES); VAV2(INDUCES); SHP-2(INDUCES); GRB2(DISRUPTS) 10069801; 10653583; 12454019; 1314835; 14560030; 15592458; 15708852; 16729043; 17575160; 19002495; 21787862; 31197039; 7506413; 8408058; 9020117 45 7 12 +Zc3hav1 ZAP RNA-binding; Transferase Q8K3Y6 252832 4q22 rat S270-p 3203916 PVVSPLGsGPPSPDV activity, induced 22514281 1 20 0 +Add2 ADD2 Cytoskeletal; Motility/polarity/chemotaxis Q05764 24171 4q34 rat S712-p 449802 KKKFRTPsFLKKSKK intracellular localization cytoskeletal reorganization 9679146 8 58 159 +LHX3 LHX3 DNA-binding; Transcription factor Q9UBR4 8022 9q34.3 human S238-p 455299 MKRSRGGsKSDKDSV activity, induced transcription, induced 15517599 1 0 0 no change in binding to DNA or to certain proteins (NLI, PIT1, or MRG1) +Ppargc1b PGC-1 beta Nuclear receptor co-regulator; Transcription, coactivator/corepressor Q8VHJ7 170826 18|18 E1 mouse K933-ac 7761211 TRSKRGQkHGFITFR RRM_1 intracellular localization transcription, inhibited 19491097 1 1 0 +Chmp5 CHMP5 Cell cycle regulation; Vesicle Q9D7S9 76959 4|4 A5 mouse S26-p 87391001 DCIGTVDsRAESIDK Snf7 protein stabilization USP8(INDUCES) 28553951 1 1 0 +MRTFA MKL1 Oncoprotein; Transcription, coactivator/corepressor Q969V6 57591 22q13.1-q13.2 human S454-p 467355 TGSTPPVsPTPSERS intracellular localization transcription, altered 18694962; 22139079 3 44 15 stimulates MKL1 binding to G-actin and its nuclear export +JUNB JunB Motility/polarity/chemotaxis; Oncoprotein; Transcription factor P17275 3726 19p13.13 human T255-p 465822 EARSRDAtPPVSPIN Jun protein degradation FBXW7(INDUCES) 22710716 1 51 16 mitosis progression and chromatid cohesion +G6PD G6PD Carbohydrate Metabolism - pentose phosphate pathway; Cell development/differentiation; EC 1.1.1.49; Other Amino Acids Metabolism - glutathione; Oxidoreductase P11413 2539 Xq28 human Y507-p 451668 GFQYEGTyKWVNPHK G6PD_C cell motility, altered 19359662 2 28 773 modulates Akt activity +NFE2L2 NRF2 DNA-binding; Transcription factor Q16236 4780 2q31.2 human Y576-p 460703 RDEDGKPySPSEYSL protein degradation; ubiquitination; intracellular localization apoptosis, induced; transcription, inhibited 21097520; 21690096; 32295843 6 1 1 +Rps6kb1 p70S6K iso2 EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, AGC; Protein kinase, Ser/Thr (non-receptor); Translation P67999-2 83840 10q26 rat S17-p 450117 DQPEDAGsEDELEEG molecular association, regulation Exportin-1(INDUCES) 16895915 2 1 6 +SHOX SHOX DNA-binding; Transcription factor O15266 6473 X;Y human S106-p 457680 EKREDVKsEDEDGQT cell cycle regulation; transcription, induced 16325853 1 1 0 +ECE1 ECE1 iso3 Cell surface; EC 3.4.24.71; Membrane protein, integral; Protease; Vesicle P42892-3 1889 1p36.12 human K6-ub 1877956802 __MMSTYkRATLDEE protein degradation cell growth, inhibited 31788944 1 0 0 K6R mutant enhances stability, tumor growth and EMT invasiveness +CYTH2 cytohesin 2 GEF; GEF, ARF Q99418 9266 19q13.33 human S392-p 450661 AARKKRIsVKKKQEQ protein stabilization; molecular association, regulation; intracellular localization; protein conformation ATP6V0A2(DISRUPTS) 10531036; 20153292; 24083777 4 1 11 increases both the helicity and stability of the C-terminus, formation of salt bridges between p-S392 and Arg390,Lys395, and Lys396 +BBC3 PUMA Apoptosis; Mitochondrial Q9BXH1 27113 19q13.32 human Y152-p 29674707 ADDLNAQyERRRQEE PUMA protein degradation; intracellular localization cell growth, induced; apoptosis, inhibited 24236056 1 0 0 +HSP90AA1 HSP90A Chaperone; Heat shock protein P07900 3320 14q32.31 human K478-ac 2884404 GDEMVSLkDYCTRMK HSP90 molecular association, regulation CHIP(DISRUPTS); TEBP(DISRUPTS); HSP70(DISRUPTS); HSP40(DISRUPTS) 18559531 1 2 0 +EZH2 EZH2 EC 2.1.1.43; METHYLTRANSFERASE; Methyltransferase; Methyltransferase, protein lysine Q15910 2146 7q36.1 human Y244-p 59087901 AEELKEKyKELTEQQ PRC2_HTH_1 molecular association, regulation; protein conformation cell growth, induced; transcription, induced POLR2A(INDUCES); PRRC2C iso2(INDUCES) DNA(INDUCES) 27297789; 32631994 2 0 0 +DNAJB1 HSP40 Chaperone; Nucleolus P25685 3337 19p13.12 human S151-p 23099871 VNFGRSRsAQEPARK transcription, inhibited 24309468 1 1 1 +CREBBP CBP ACETYLTRANSFERASE; Acetyltransferase; DNA-binding; EC 2.3.1.48; Motility/polarity/chemotaxis; Nuclear receptor co-regulator; Transcription, coactivator/corepressor Q92793 1387 16p13.3 human R742-me 475951 PQAPMGPrAASPMNH molecular association, regulation; acetylation; enzymatic activity, induced transcription, induced; signaling pathway regulation RAC3(INDUCES); ER-alpha(INDUCES) DNA(INDUCES) 12374746; 21632823 2 0 0 steroid hormone signaling, GRIP1 and steroid hormone-induced transcription; induces CBP autoacetylation +LRRK1 LRRK1 EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, Ser/Thr (non-receptor); Protein kinase, TKL Q38SD2 79705 15q26.3 human T1427-p 41694202 GALGVEGtPGYQAPE Pkinase molecular association, regulation; enzymatic activity, induced; phosphorylation cytoskeletal reorganization WDR34(INDUCES); WDR60(INDUCES) 26192437; 36254578 2 0 0 +Abcc9 ABCC9 Channel, potassium; Membrane protein, integral; Membrane protein, multi-pass; Transporter; Transporter, ABC family Q63563 25560 4q44 rat S636-p 41608700 KKHTGVQsKPINRKQ activity, induced; protein stabilization; protein conformation 26198630 1 1 0 +ATF4 ATF-4 DNA-binding; Transcription factor P18848 468 22q13.1 human S219-p 448436 DTPSDNDsGICMSPE protein degradation; protein stabilization; molecular association, regulation transcription, altered BRD8 iso2(INDUCES); FBW1B(INDUCES) 11238952; 18052253; 21706477 4 0 0 +Gab1 GAB1 Adaptor/scaffold; Motility/polarity/chemotaxis Q9QYY0 14388 8|8 C2 mouse S552-p 454074 ELQAPVRsPITRSFA activity, induced; molecular association, regulation; intracellular localization; protein conformation GAB1(DISRUPTS) 19050043; 25460044; 28365441 3 9 0 +Pde4d PDE4D iso6 EC 3.1.4.53; Nucleotide Metabolism - purine; Phosphodiesterase P14270-6 24627 rat S585-p 451090 YQSTIPQsPSPAPDD cell cycle regulation 24815749 7 3 0 +Dab1 DAB1 iso2 Adaptor/scaffold P97318-2 13131 4 C6|4 47.79 cM mouse T476-p 479419 LTPVTSTtPSTNSPP phosphorylation 16529723 1 0 0 inhibits tyrosine phosphorylation +YAP1 YAP1 Oncoprotein; Transcription, coactivator/corepressor P46937 10413 11q22.1 human S164-p 471933 AQHLRQSsFEIPDDV cell growth, induced; cell growth, inhibited; apoptosis, induced; cell motility, altered; transcription, inhibited 24658687; 28416665 13 16 45 sensitivity to gemcitabine +MRTFA MKL1 Oncoprotein; Transcription, coactivator/corepressor Q969V6 57591 22q13.1-q13.2 human K499-sm 2407402 SPLQILVkEEGPRAG transcription, inhibited 16098147 1 1 0 +FOXM1 FOXM1 iso2 DNA-binding; Transcription factor Q08050-2 2305 12p13.33 human K463-sm 31898503 PHLARPIkVESPPLE protein degradation transcription, inhibited 25533473 2 0 0 +Cd79a Ig-alpha Immunoglobulin superfamily; Membrane protein, integral P11911 12518 7 A3|7 13.49 cM mouse Y204-p 447752 SRGLQGTyQDVGNLH activity, induced; molecular association, regulation; intracellular localization cell differentiation, altered; signaling pathway regulation; cell growth, altered GRB2(INDUCES); BLNK(INDUCES); VAV1(INDUCES) 11449366; 11859098; 11909947; 16860757; 17163454 6 5 30 Ca(2+) signaling; promotes B cell activation, proliferation and differentiation. +CSF3R GCSFR Membrane protein, integral; Receptor, cytokine Q99062 1441 1p34.3 human Y787-p 449311 LTPSPKSyENLWFQA activity, induced; molecular association, regulation; activity, inhibited; phosphorylation cell growth, altered SHIP(INDUCES); SHC1(INDUCES) 15470047; 8547634 5 0 0 SHIP and Shc phosphorylation +LASP1 Lasp-1 Actin-binding; Motility/polarity/chemotaxis O77506 100009568 rabbit S99-p 450464 KNKGRGFsVVADTPE intracellular localization cytoskeletal reorganization 12432067 1 6 1 +Cacna1c CACNA1C iso5 Channel, calcium; Membrane protein, integral; Membrane protein, multi-pass Q0PCR6 12288 6 F1|6 55.86 cM mouse T1704-p 17620920 RAISGDLtAEEELDK CAC1F_C activity, induced 24218620 9 1 0 increased channel current and contractility in response to beta-adrenergic stimulation, exercise capacity and cardiac function in vivo +FPR2 FPR2 GPCR, family 1; Membrane protein, integral; Membrane protein, multi-pass; Motility/polarity/chemotaxis; Receptor, GPCR P25090 2358 19q13.41 human S236-p 3176601 HKKGMIKsSRPLRVL 7tm_1 receptor desensitization, altered 11063592 1 0 0 downregulates PLA2 and PLD activation +ETV5 ERM DNA-binding; Transcription factor P41161 2119 3q27.2 human K468-sm 2887210 DNQRPFLkAESECHL transcription, inhibited 18243147 1 0 0 +Dll1 DLL1 Cell development/differentiation; Membrane protein, integral; Motility/polarity/chemotaxis Q61483 13388 17 A2|17 8.95 cM mouse T638-p 31012807 SFKVRYPtVDYNLVR transcription, induced 24449764 1 1 0 mutant shows increased stability +NONO NONO Nuclear receptor co-regulator; Nucleolus; RNA splicing; RNA-binding Q15233 4841 Xq13.1 human K371-ac 9263619 RRQQEGFkGTFPDAR transcription, induced 35843094 1 1 7 transcription of the IL-8 gene +EPM2A laforin EC 3.1.3.16; EC 3.1.3.48; Motility/polarity/chemotaxis; PHOSPHATASE; Protein phosphatase, dual-specificity O95278 7957 6q24.3 human S25-p 20583300 PELLVVGsRPELGRW CBM_20 protein stabilization; molecular association, regulation; enzymatic activity, induced laforin(INDUCES); NHLRC1(INDUCES); PPP1CA(INDUCES); AMPKA2(INDUCES) 21728993 1 1 0 +ZNF281 ZNF281 C2H2-type zinc finger protein; DNA-binding; Transcription factor Q9Y2X9 23528 1q32.1 human S807-p 460884 STGFQIPsQELASQI intracellular localization DNA repair, induced 31570788 1 3 4 +TRPS1 TRPS1 C2H2-type zinc finger protein; Transcription factor Q9UHF7 7227 8q23.3 human K1201-sm 3278911 EGPLNVVkTEKVDRS transcription, inhibited 17391059 2 4 0 +PTPN1 PTP1B EC 3.1.3.48; Motility/polarity/chemotaxis; PHOSPHATASE; Phosphatase; Protein phosphatase, tyrosine (non-receptor) P18031 5770 20q13.13 human S286-p 27528603 KFIMGDSsVQDQWKE enzymatic activity, induced apoptosis, induced 23348582 1 0 0 S286 phosphorylation promotes mitotic cell death. +MSH5 MSH5 Cell cycle regulation; DNA repair, damage; DNA replication O43196 4439 6p21.33 human Y742-p 29570701 GNDLVFFyQVCEGVA MutS_V molecular association, regulation DNA repair, induced DNA(INDUCES) 24023853 1 0 0 +Slc5a5 SLC5A5 Membrane protein, integral; Membrane protein, multi-pass; Transporter; Transporter, SLC family Q63008 114613 16p14 rat S43-p 990307 LARGGQRsADDFFTG activity, induced 17913707 1 1 1 +ERBB3 HER3 EC 2.7.10.1; KINASE; Kinase, protein; Membrane protein, integral; Oncoprotein; Protein kinase, TK; Protein kinase, tyrosine (receptor) P21860 2065 12q13.2 human Y1328-p 451650 SAFDNPDyWHSRLFP molecular association, regulation SHC1(INDUCES) 16729043 4 17 216 +EIF4E EIF4E Translation; Translation initiation P06730 1977 4q23 human K159-ub 486277 AVVNVRAkGDKIAIW IF4E protein degradation; molecular association, regulation; phosphorylation translation, altered eIF4G(DISRUPTS) 16720573 1 0 0 inhibits phosphorylation +SLC6A3 DAT Membrane protein, integral; Membrane protein, multi-pass; Transporter; Transporter, SLC family Q01959 6531 5p15.33 human T48-p 1385533601 QLTSSTLtNPRQSPV palmitoylation 30587577 1 1 0 Increased palmitoylation in dephosphomimetic mutant. +ZEB2 ZEB2 C2H2-type zinc finger protein; DNA-binding; Motility/polarity/chemotaxis; Transcription, coactivator/corepressor O60315 9839 2q22.3 human K866-sm 3726901 PLNLTFIkKEFSNSN molecular association, regulation transcription, induced CTBP1(DISRUPTS) 16061479 1 1 0 +SENP3 SENP3 DESUMOYLASE; EC 3.4.22.68; Nucleolus; Protease; Sumo-specific protease Q9H4L4 26168 17p13.1 human S26-p 4957737 GIPPAYSsPRRERLR molecular association, regulation; intracellular localization NPM1(INDUCES) 25288641 1 4 15 ribosome biogenesis-28S rRNA maturation +Cttn Cortactin Actin-binding; Cytoskeletal; Motility/polarity/chemotaxis Q60598 13043 7|7 F5 mouse K235-ac 461721 YVKGFGGkFGVQTDR HS1_rep molecular association, regulation; acetylation; intracellular localization DIP2A(INDUCES) 31600191 2 4 21 DIP2A regulates spine morphology and synaptic transmission through acetylation of cortactin; Interaction of DIP2A-cortactin is required for acetylated cortactin; acetylation mimetic cortactin rescues the repetitive behaviors in Dip2a KO mice; acetylation alleviated abnormal PSD95 clustering at the spine head in DIP2A KO neurons +GJA8 GJA8 Channel, misc.; Membrane protein, integral; Membrane protein, multi-pass P48165 2703 1q21.2 human S258-p 2574911 SLHSIAVsSIQKAKG protein stabilization; intracellular localization 35120923 1 2 0 +LMNB1 Lamin B1 Cytoskeletal P20700 4001 5q23.2 human T575-p 3177672 ELFHQQGtPRASNRS molecular association, regulation; intracellular localization Oct1(DISRUPTS) 28542436 1 32 57 +Npm1 NPM1 Nucleolus; Oncoprotein; RNA-binding; Translation Q61937 18148 11|11 A4 mouse S88-p 4169620 MSVQPTVsLGGFEIT Nucleoplasmin protein conformation 24616519 2 12 0 +MARK2 MARK2 EC 2.7.11.1; EC 2.7.11.26; KINASE; Kinase, protein; Protein kinase, CAMK; Protein kinase, Ser/Thr (non-receptor) Q7KZI7 2011 11q13.1 human S400-p 5635600 HKVQRSVsANPKQRR molecular association, regulation; intracellular localization 14-3-3 beta(INDUCES) 19011111 1 5 0 +Hnf4a HNF4 alpha DNA-binding; Nuclear receptor; Transcription factor P49698 15378 2 H3|2 84.32 cM mouse S318-p 20510201 LRSQVQVsLEDYIND Hormone_recep molecular association, regulation SSU72(INDUCES) 34616001 2 1 0 +KRT6A K6a Cytoskeletal P02538 3853 12q13.13 human K194-ub 15492068 QNKVLETkWTLLQEQ Filament ubiquitination 29191848 1 1 1 +CETN2 CETN2 Calcium-binding; Cell cycle regulation; DNA repair, damage P41208 1069 Xq28 human S170-p 448199 LRIMKKTsLY_____ molecular association, regulation; protein stabilization; protein conformation cell cycle regulation; cell growth, altered XPC(DISRUPTS) 11279195; 21731694; 31202846 4 0 0 centrosome amplification +Irak1bp1 IRAK1BP1 Transcription regulation Q9ESJ7 65099 9|9 E2 mouse T246-p 12524605 AASKVFItFEVKGKE SIMPL intracellular localization transcription, altered 17079333 1 0 1 nuclear localization +H2-Eb1 HLA-DRB1 Membrane protein, integral P18468 14969 17 B1|17 17.98 cM mouse K225-ub 3597309 QSTSAQNkMLSGVGG receptor recycling, inhibited; protein degradation endocytosis, altered 16785530; 17255932 3 0 0 +BCAR1 P130Cas Adaptor/scaffold; Motility/polarity/chemotaxis P56945 9564 16q23.1 human S437-p 8069100 SSTGSTRsSQSASSL intracellular localization cell motility, altered 19454314 1 1 0 +STARD10 STARD10 Q9Y365 10809 11q13.4 human S284-p 483984 GGAGGEGsDDDTSLT activity, inhibited 17561512 1 30 6 Inhibits lipid transfer activity in vitro +Prkcd PKCD EC 2.7.11.13; KINASE; Kinase, protein; Nuclear receptor co-regulator; Protein kinase, AGC; Protein kinase, Ser/Thr (non-receptor); Protein kinase, tyrosine (non-receptor); Tumor suppressor P28867 18753 14 B|14 18.82 cM mouse Y311-p 447573 TTESVGIyQGFEKKP intracellular localization; phosphorylation; enzymatic activity, induced apoptosis, induced 27531930; 33932405; 33995031 44 60 1707 +RBBP8 CtIP EC 3.1.-.-; Transcription, coactivator/corepressor Q99708 5932 18q11.2 human T731-p 1868101002 LEDMFDRtTHEEYES cell cycle regulation; DNA repair, inhibited 30202980 1 0 0 supress DSB end resection +MACF1 ACF7 Actin-binding; Cytoskeletal; Motility/polarity/chemotaxis Q9UPN3 23499 1p34.3 human S7230-p 18507014 KPSSRAAsPTRSSSS intracellular localization cell motility, induced; cytoskeletal reorganization 21295697 1 3 2 inhibits localization along microtubules, alters organization of microtubules, regulates skin wound repair, SC migration +ZFPM1 FOG1 C2H2-type zinc finger protein; Transcription regulation Q8IX07 161882 16q24.2 human K463-sm 14988612 PAAPRSIkVEAVEEP molecular association, regulation CTBP1(INDUCES) 20587419 1 0 0 +Tbc1d1 TBC1D1 DEUBIQUITINASE; GAP; GAP, Rab; Ubiquitin-specific protease Q60949 57915 5 C3.1|5 32.8 cM mouse T499-p 2228808 NRAKRSLtESLESIL activity, inhibited 19740738 2 7 2 reduces inhibitory effect on TBC1D1 on GLUT4 translocation +Gata4 GATA4 Motility/polarity/chemotaxis; Transcription factor P46152 54254 15p12 rat S261-p 450013 IKPQRRLsASRRVGL activity, induced; molecular association, regulation cell growth, induced; transcription, induced p300(INDUCES); NKX2-5(INDUCES) DNA(INDUCES) 12670947; 22227582 9 1 1 +FBXL2 FBXL2 UBIQUITIN LIGASE; Ubiquitin ligase Q9UKC9 25827 3p22.3 human T404-p 15278700 HAYFAPVtPPTAVAG molecular association, regulation; ubiquitination FBXO3(INDUCES) 23542741; 27010866 2 4 2 ApaG domain alone is necessary, but not sufficient for binding and degradation of FBxl2; induces ubiquitination of FBXL2-K201; T404 FBLX2 phosphorylated peptide does not bind FBxo3 ApaG domain in vitro +PDE3A PDE3A EC 3.1.4.17; Membrane protein, integral; Membrane protein, multi-pass; Nucleotide Metabolism - purine; Phosphodiesterase Q14432 5139 12p12.2 human S428-p 456821 IPKRLRRsLPPGLLR molecular association, regulation; enzymatic activity, induced cell growth, induced 14-3-3 beta(INDUCES); 14-3-3 sigma(INDUCES) 16153182; 19261611; 25961942 5 11 1 +IL6ST gp130 Membrane protein, integral; Receptor, cytokine P40189 3572 5q11.2 human Y915-p 448183 QTVRQGGyMPQ____ cell cycle regulation; transcription, altered 10623831 2 1 7 +RPS3 RPS3 Apoptosis; EC 4.2.99.18; RNA-binding; Ribosomal; Translation P23396 6188 11q13.4 human T42-p 455909 SGVEVRVtPTRTEII KH_2 intracellular localization 17560175 2 0 0 translocation to nucleus +UBXN7 UBXN7 Unknown function O94888 26043 3q29 human K99-ub 6778629 EPLFGAPkRRRPARS protein degradation; ubiquitination signaling pathway regulation 36096451 1 11 39 HBV X protein promotes K48-linked ubiquitination of UBXN7 protein at K99, UBXN7 up-regulated ubiquitination of IKKB and inhibits NF-kB signaling pathway by promoting the degradation of IKK-beta +CCDC88A girdin Actin-binding Q3V6T2 55704 2p16.1 human S1690-p 27811900 LQQFLEEsNKLTSVQ molecular association, regulation; phosphorylation cell growth, induced; cytoskeletal reorganization; cell motility, inhibited G-alpha(s)(INDUCES); G-alpha i3(DISRUPTS); G-alpha i1(DISRUPTS) 23509302; 27621449; 31363053 3 0 0 Akt phosphorylation inhibited +HK1 HK1 Carbohydrate Metabolism - amino sugar and nucleotide sugar; Carbohydrate Metabolism - fructose and mannose; Carbohydrate Metabolism - galactose; Carbohydrate Metabolism - glycolysis and gluconeogenesis; Carbohydrate Metabolism - starch and sucrose; EC 2.7.1.1; Kinase, other; Mitochondrial P19367 3098 10q22.1 human Y732-p 462391 YDRLVDEySLNAGKQ Hexokinase_2 protein conformation; enzymatic activity, induced cell motility, induced; cell growth, induced 28054552 1 2 35 promote cell migration and invasion; tumour incidence and metastasis +Prkab1 AMPKB1 Autophagy; KINASE; Protein kinase, regulatory subunit P80386 83803 12q16 rat S182-p 448110 DVSELSSsPPGPYHQ intracellular localization 11171104 4 17 1 +WWTR1 TAZ Oncoprotein; Transcription, coactivator/corepressor Q9GZV5 25937 3q25.1 human T326-p 41594201 GCYSVPTtPEDFLSN protein degradation; activity, inhibited carcinogenesis, inhibited; cell growth, inhibited; cell motility, inhibited; transcription, inhibited 26183396; 26375055 2 0 0 +CDC25C CDC25C EC 3.1.3.48; Motility/polarity/chemotaxis; PHOSPHATASE; Protein phosphatase, dual-specificity P30307 995 5q31.2 human T48-p 448419 VCPDVPRtPVGKFLG protein degradation; molecular association, regulation cell cycle regulation; cell adhesion, altered NEDD4(INDUCES); PIN1(INDUCES) 10037602; 24710276; 8119945 7 10 15 +CARD9 CARD9 Adaptor/scaffold Q9H257 64170 9q34.3 human K125-ub 50760800 LLMTEVMkLQKKVQD activity, induced transcription, induced; signaling pathway regulation 26488816 1 0 0 regulates anti-fungal innate immune signaling via C-type lectin receptor +Pdx1 PDX1 DNA-binding; Transcription factor P52947 29535 12p11 rat Y68-p 458821 SPPDISPyEVPPLAD activity, induced; molecular association, regulation transcription, induced p300(INDUCES) 15001545 1 0 0 +SMAD6 SMAD6 DNA-binding; Transcription factor O43541 4091 15q22.31 human R82-m2 1880719800 RGAQGAGrRRRAGGP molecular association, regulation; intracellular localization cell differentiation, inhibited SMAD1(INDUCES) 33667543 2 0 0 Disrupts SMAD1-SMAD4 complex formation,required for nuclear localization of SMAD1, promotes cell invasion, inhibits osteogenic differentiation +IRF5 IRF5 DNA-binding; Transcription factor Q13568 3663 7q32.1 human K411-ub 4666601 PDRKPREkKLITVQV IRF-3 molecular association, regulation; ubiquitination; intracellular localization transcription, induced; transcription, inhibited LYN(INDUCES) 18824541; 27521268 2 1 0 pro-inflammatory cytokine gene transcription; nuclear translocation; inhibition of IRF5 activation by Lyn requires their physical Interaction, Lyn inhibits IRF5 ubiquitination and phosphorylation by protecting IRF5 from each of PTM enzymes +Pdpk1 PDK1 EC 2.7.11.1; KINASE; Kinase, protein; Nuclear receptor co-regulator; Protein kinase, AGC; Protein kinase, Ser/Thr (non-receptor) Q9Z2A0 18607 17|17 A3.3 mouse S244-p 447693 SKQARANsFVGTAQY Pkinase enzymatic activity, induced cell growth, induced 11570885; 14623982; 35210408 63 95 264 +Irs1 IRS1 Adaptor/scaffold; Motility/polarity/chemotaxis P35569 16367 1 C5|1 42.0 cM mouse S307-p 447558 TESITATsPASMVGG phosphorylation neural plasticity; cell differentiation, inhibited; signaling pathway regulation 10722755; 21852229; 32075735; 34694913 77 14 0 +AKT1 Akt1 EC 2.7.11.1; KINASE; Kinase, protein; Oncoprotein; Protein kinase, AGC; Protein kinase, Ser/Thr (non-receptor) P31749 207 14q32.33 human S129-p 450019 SGSPSDNsGAEEMEV molecular association, regulation; phosphorylation; enzymatic activity, induced cell cycle regulation; carcinogenesis, induced; cell motility, induced; cell growth, induced; apoptosis, inhibited; transcription, induced; signaling pathway regulation palladin(INDUCES) 15818404; 21159648; 21735093; 24769357; 36243702 13 48 2 +DDX17 DDX17 iso3 EC 3.6.4.13; Helicase; Nuclear receptor co-regulator; Nucleolus; RNA processing; RNA-binding; Spliceosome; Transcription, coactivator/corepressor Q92841-3 10521 22q13.1 human K29-ac 15211507 GGGGLPPkKFGNPGE protein stabilization; molecular association, regulation cell cycle regulation; apoptosis, inhibited HDAC3(INDUCES); HDAC1(INDUCES) 20663877 1 1 0 +Trpv1 TRPV1 Channel, cation; Membrane protein, integral; Membrane protein, multi-pass; Receptor, misc. O35433 83810 10q24 rat T370-p 455383 RHLSRKFtEWAYGPV molecular association, regulation; receptor desensitization, altered ARRB2 iso2(INDUCES) 15691846; 23360390 4 0 0 +Frs2 FRS2 Adaptor/scaffold Q8C180 327826 10|10 D2 mouse Y196-p 448153 AEEQVHTyVNTTGVQ molecular association, regulation GRB2(INDUCES) 9182757 7 3 9 +G6pd2 G6PD-2 EC 1.1.1.49; Oxidoreductase P97324 14380 5 C3.1|5 31.99 cM mouse T10-p 1869062303 EQVTLSRtQVCGILR enzymatic activity, induced carcinogenesis, induced; cell growth, induced 32259365 1 0 0 +Yap1 YAP1 Oncoprotein; Transcription, coactivator/corepressor P46938 22601 9|9 A1 mouse Y392-p 473004 SGLSMSSySIPRTPD protein stabilization; molecular association, regulation; intracellular localization transcription, induced; signaling pathway regulation TEAD1(INDUCES); TEAD4(INDUCES); Src iso1(INDUCES); gp130(INDUCES) 23708000; 25731159; 31018132; 33474722 23 3 4 +LPO LPO EC 1.11.1.7; Oxidoreductase; Secreted; Secreted, signal peptide ABN41562 100860761 goat S315-p 1779806 LVYGSEPsLASRLRN An_peroxidase enzymatic activity, induced 18191143 2 0 0 facilitates calcium ion binding +Foxo1 FOXO1A DNA-binding; Nuclear receptor co-regulator; Oncoprotein; Transcription factor Q9R1E0 56458 3 C|3 23.19 cM mouse S253-p 448075 SPRRRAAsMDNNSKF protein degradation; molecular association, regulation; ubiquitination; intracellular localization; activity, inhibited; phosphorylation cell cycle regulation; apoptosis, induced; cell motility, inhibited; transcription, induced; signaling pathway regulation; cell growth, induced; apoptosis, inhibited; transcription, inhibited 10377430; 10698940; 11375271; 20921625; 22848439; 25119572; 26929406; 28559285; 33503413; 33530926; 33786575; 34556581; 35197460; 35878408; 36870057 98 8 48 +CDKN2A p16-INK4A Cell cycle regulation; Nucleolus; Tumor suppressor P42771 1029 9p21.3 human S8-p 448830 MEPAAGSsMEPSADW protein stabilization; activity, inhibited 20152798; 21270107 3 0 0 +CSF2RB CSF2RB Membrane protein, integral; Receptor, cytokine P32927 1439 22q12.3 human S601-p 448463 LGPPHSRsLPDILGQ activity, induced; molecular association, regulation; phosphorylation apoptosis, inhibited; transcription, altered 14-3-3 beta(INDUCES); PIK3R1(INDUCES) 10477722; 10949031; 12920017 6 1 0 S601 is important for NF-kB and Akt activation, and Bcl-2 expression. +Map2 MAP2 iso3 Cytoskeletal; Motility/polarity/chemotaxis P15146-3 25595 9q32 rat K107-ac 62495519 AEAVAVLkGEQEKEA cytoskeletal reorganization 28002468 1 1 0 +Rims1 RIMS1 Adaptor/scaffold; Vesicle Q9JIR4 84556 9q13 rat S241-p 455663 RLQERSRsQTPLSTA molecular association, regulation 14-3-3 beta(INDUCES); 14-3-3 gamma(INDUCES); 14-3-3 eta(INDUCES) 12871946 1 0 0 +CTTN Cortactin Actin-binding; Cytoskeletal; Motility/polarity/chemotaxis Q14247 2017 11q13.3 human S113-p 465664 SKLSKHCsQVDSVRG HS1_rep molecular association, regulation carcinogenesis, induced; cell motility, induced; cytoskeletal reorganization ARPC1B(INDUCES); ARPC2(INDUCES) 24859002; 30562756 3 16 17 destabilization of invadopodia structures through serine phosphorylation of cortactin; Arp2/3 complex binding; S113A mutant dissasembled invadopodia only 30% of the time +Fndc5 FNDC5 Membrane protein, integral Q8K4Z2 384061 4|4 D2.2 mouse K177-ac 1881215703 CRQYDIIkDNEPNNN ubiquitination 33754067 1 0 0 SIRT2-dependent deacetylation and deubiquitination increases stability +STK3 MST2 Autophagy; EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, STE; Protein kinase, Ser/Thr (non-receptor) Q13188 6788 8q22.2 human T336-p 3801535 TSVESVGtMRATSTM ubiquitination; intracellular localization; phosphorylation cell cycle regulation; carcinogenesis, induced 37739411 1 8 33 TRIM69 regulates centrosome dynamics and mitotic progression and centrosome amplification, regulates centrosome clustering, promotes triple-negative breast cancer; TRIM69A regulates MST2 ubiquitination and intracellular localization +Cers2 LASS2 DNA-binding; Membrane protein, integral; Membrane protein, multi-pass; Transferase Q924Z4 76893 3|3 F2.1 mouse T346-p 469769 ERSDREEtESSEGEE enzymatic activity, induced 26887952 1 42 217 +Flot2 FLOT2 Cell adhesion Q9Z2S9 83764 10q25 rat Y163-p 475941 DVYDKVDyLSSLGKT Band_7 molecular association, regulation; intracellular localization cell motility, altered; cytoskeletal reorganization FLOT1(INDUCES) 17213334; 19318123 4 3 36 +PTPN3 PTPN3 EC 3.1.3.48; Motility/polarity/chemotaxis; PHOSPHATASE; Protein phosphatase, tyrosine (non-receptor) P26045 5774 9q31.3 human S835-p 451192 VRSLRVDsEPVLVHC Y_phosphatase molecular association, regulation 14-3-3 beta(INDUCES) 9341175 1 0 1 +KRT12 K12 Cytoskeletal Q99456 3859 17q21.2 human K189-ub 52490402 LIEDLRNkIISASIG Filament protein degradation 26676607 0 1 0 +Mdm2 MDM2 EC 6.3.2.-; EC 6.3.2.19; Inhibitor; Ligase; NEDDYLATION LIGASE; Neddylation Ligase; Nucleolus; Oncoprotein; UBIQUITIN LIGASE; Ubiquitin conjugating system; Ubiquitin ligase P23804 17246 10 D2|10 66.32 cM mouse S183-p 448131 RHRKRRRsLSFDPSL carcinogenesis, induced; apoptosis, inhibited 20841468 14 9 2 coexpression of S163D/S183D with Neu results in faster tumor formation +STAT5B STAT5B DNA-binding; Oncoprotein; Transcription factor P51692 6777 17q21.2 human K705-ac 62484404 GYVKPQIkQVVPEFV phosphorylation transcription, induced 23980167 1 0 0 increases pSTAT5B at Y699 +SMAD4 SMAD4 DNA-binding; Nuclear receptor co-regulator; Transcription, coactivator/corepressor Q13485 4089 18q21.2 human T273-p 36694102 TTWTGSRtAPYTPNL protein degradation; molecular association, regulation; ubiquitination carcinogenesis, inhibited; transcription, inhibited; signaling pathway regulation BTRC(INDUCES) 25373906 1 0 0 +IRF7 IRF7 DNA-binding; Transcription factor Q92985 3665 11p15.5 human S471-p 1276102 GTQREGVsSLDSSSL transcription, inhibited 10893229 3 0 0 +FMNL2 FMNL2 iso3 Cytoskeletal Q96PY5-3 114793 2q23.3 human S1072-p 48891101 RADAVRRsVRRRFDD molecular association, regulation; intracellular localization endocytosis, induced; cell motility, induced ITGA5(INDUCES) 26256210 1 0 0 localization from the plasma membrane to endosomal membrane compartments, promoted cell invasion +CAT Catalase Amino Acid Metabolism - tryptophan; Apoptosis; EC 1.11.1.6; Endoplasmic reticulum; Energy Metabolism - methane; Hydrolase; Mitochondrial; Oxidoreductase P04040 847 11p13 human Y386-p 450445 YRARVANyQRDGPMC Catalase enzymatic activity, induced 12777400 2 0 0 +HSPB1 HSP27 Chaperone; Heat shock protein; Motility/polarity/chemotaxis; SUMO LIGASE; SUMO ligase P15991 hamster S90-p 448403 RALNRQLsSGVSEIR activity, induced; molecular association, regulation apoptosis, altered IKKA(INDUCES); HSP27(DISRUPTS) 10092617; 15033973; 15944157; 16840786 78 104 289 +Pex14 PEX14 Adaptor/scaffold Q642G4 64460 5q36 rat S247-p 1869992403 SWQIPVKsPSPSSPA molecular association, regulation; intracellular localization Catalase(DISRUPTS) 32831175 1 1 0 regulates peroxisomal catalase import +ALDOA ALDOA Carbohydrate Metabolism - fructose and mannose; Carbohydrate Metabolism - glycolysis and gluconeogenesis; Carbohydrate Metabolism - pentose phosphate pathway; EC 4.1.2.13; KINASE; Lyase; Mitochondrial P00883 100009055 rabbit H362-p 451798 ESLFISNhAY_____ Glycolytic enzymatic activity, inhibited 2275541 1 0 0 +SLC29A1 SLC29A1 Membrane protein, integral; Membrane protein, multi-pass; Transporter; Transporter, SLC family Q99808 2030 6p21.1 human S281-p 21326706 QPTNESHsIKAILKN Nucleoside_tran activity, induced 25725289 2 1 0 +RPS6KA3 RSK2 EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, AGC; Protein kinase, Ser/Thr (non-receptor) P51812 6197 Xp22.12 human S227-p 448063 DHEKKAYsFCGTVEY Pkinase activity, induced; enzymatic activity, induced carcinogenesis, induced; cell growth, induced; apoptosis, inhibited 10980595; 23012246; 23708659 14 43 151 upregulation of c-Myc, p21WAF1/CIP1, CCND2 and MCL1 +Fzd3 FZD3 GPCR, Fz/Smo family; Membrane protein, integral; Membrane protein, multi-pass; Receptor, GPCR Q61086 14365 14 D1|14 34.09 cM mouse S637-p 18507002 NEQSRHSsIRDLSNN receptor internalization, inhibited; phosphorylation endocytosis, inhibited 21316586 1 0 0 enhances PCP signaling, regulating c-Jun phosphorylation, and affecting growth cone guidance +TLN1 talin 1 Cytoskeletal; Motility/polarity/chemotaxis Q9Y490 7094 9p13.3 human S446-p 4704923 VGKVEHGsVALPAIM cell motility, altered; cell adhesion, inhibited 27698901 1 4 0 +Brsk2 BRSK2 EC 2.7.11.1; EC 2.7.11.26; KINASE; Kinase, protein; Protein kinase, CAMK; Protein kinase, Ser/Thr (non-receptor) Q69Z98 75770 7|7 F5 mouse T452-p 4734897 PKGTPVHtPKESPAG protein stabilization; enzymatic activity, inhibited; phosphorylation 23790753 1 1 0 inhibits axon branching (activated in BRSK2 18A mutant) +Tal1 TAL1 DNA-binding; Oncoprotein; Transcription factor P22091 21349 4 D1|4 52.73 cM mouse K221-ac 458991 IPTHPPDkKLSKNEI HLH molecular association, regulation cell differentiation, induced; transcription, induced SIN3A(DISRUPTS) DNA(INDUCES) 11118214 1 0 1 +EXO1 EXO1 EC 3.1.-.-; Hydrolase Q9UQ84 9156 1q43 human S746-p 1240803 PGLYKSSsADSLSTT molecular association, regulation; protein conformation chromatin organization, altered; signaling pathway regulation 14-3-3 beta(INDUCES); 14-3-3 sigma(INDUCES); 14-3-3 gamma(INDUCES); 14-3-3 eta(INDUCES) 22222486; 31053472 2 7 3 Ca2+- CAMKK2-AMPK-Exo1 signaling pathway +SMAD3 SMAD3 DNA-binding; Nuclear receptor co-regulator; Transcription factor P84022 4088 15q22.33 human K333-m3 1883845002 WHPATVCkIPPGCNL activity, induced; intracellular localization carcinogenesis, induced; cell motility, induced 35085106 1 1 0 targeting SMAD3 K53/K333 methylation inhibits cancer metastasis; membrane localization; promotes migration and invasion +DAP3 DAP3 Apoptosis; Mitochondrial; Nuclear receptor co-regulator P51398 7818 1q22 human T216-p 2226202 VWNKREStEKGSPLG DAP3 apoptosis, induced 18227431 1 1 0 +APEX1 APE1 DNA repair, damage; DNA-binding; Deoxyribonuclease; EC 4.2.99.18; Endoplasmic reticulum; Hydrolase; Lyase; Nuclear receptor co-regulator; Nucleolus; Transcription, coactivator/corepressor P27695 328 14q11.2 human K25-ub 6423509 RTEPEAKkSKTAAKK protein degradation; enzymatic activity, altered 19219073 1 0 0 +Igf1r IGF1R EC 2.7.10.1; KINASE; Kinase, protein; Membrane protein, integral; Protein kinase, TK; Protein kinase, tyrosine (receptor) Q60751 16001 7 C|7 37.27 cM mouse Y1168-p 448388 DIYETDYyRKGGKGL PK_Tyr_Ser-Thr intracellular localization; enzymatic activity, induced cell cycle regulation; cell growth, induced; cell differentiation, induced 23954591; 35320720; 8940173 16 15 107 +MAPT Tau iso8 ACETYLTRANSFERASE; Acetyltransferase; Cytoskeletal P10636-8 4137 17q21.31 human K353-ac 1877491202 FKDRVQSkIGSLDNI Tubulin-binding molecular association, regulation; protein conformation 34426645 2 1 0 acetylation mimetics are aggregation resistant, inhibit prion-like seeded P301L mutation aggregation, alter conformation of P301L/S320F aggregation; reduced tau microtuble interactions +NR4A1 Nur77 Apoptosis; DNA-binding; Nuclear receptor P22736 3164 12q13.13 human T366-p 1881000304 ASPANLLtSLVRAHL cell adhesion, induced; transcription, induced; signaling pathway regulation 36623453 1 1 0 induces the ?3 integrin/FAK signalling pathway +FEN1 FEN1 DNA repair, damage; DNA-binding; Deoxyribonuclease; EC 3.1.-.-; Nuclear receptor co-regulator; Nucleolus; Ribonuclease P39748 2237 11q12.2 human R192-me 15550800 FGSPVLMrHLTASEA XPG_I molecular association, regulation; methylation; intracellular localization; phosphorylation cell cycle regulation PCNA(INDUCES) 20729856; 32783654 2 1 0 R192 methylation inhibits succinylation +DLG4 PSD-95 Adaptor/scaffold P78352 1742 17p13.1 human S78-p 1875393400 GNSGLGFsIAGGTDN PDZ molecular association, regulation NMDAR2B(DISRUPTS); Stargazin(DISRUPTS) Other(DISRUPTS) 34761188 0 1 0 inhibits binding to AVLX-144 +Cap1 CAP1 Actin-binding; Cytoskeletal P40124 12331 4|4 D2.2 mouse S309-p 2525971 PKPQTSPsPKPATKK molecular association, regulation; intracellular localization cytoskeletal reorganization; cell motility, inhibited Cofilin-1(DISRUPTS); ACTA1(INDUCES) 25315833 5 47 6 +TAX1BP1 TAX1BP1 Apoptosis Q86VP1 8887 7p15.2 human S25-p 1336919201 IFQNVAKsYLPNAHL SKICH molecular association, regulation autophagy, altered NAP1L1(INDUCES) 30459273 1 0 0 +MSX2 MSX2 DNA-binding; Transcription, coactivator/corepressor P35548 4488 5q35.2 human T141-p 25554904 CTLRKHKtNRKPRTP protein stabilization cell differentiation, inhibited; transcription, inhibited 22633971 1 0 0 +Nolc1 NOLC1 Nucleolus; RNA-binding; Transcription, coactivator/corepressor P41777 64896 1q54 rat S628-p 455686 KGEKRASsPFRRVRE activity, induced transcription, altered 12167624 1 37 13 +DAB2IP DAB2IP iso2 GAP; GAP, Ras; Tumor suppressor Q5VWQ8-2 153090 9q33.2 human T531-p 1875342306 DVHTALStPGSGQLP DUF3498 ubiquitination; phosphorylation cell cycle regulation; carcinogenesis, inhibited; chromatin organization, altered; cytoskeletal reorganization PLK1(INDUCES) 34775484 1 0 0 inhibitrs CDC20 ubiquitination, induces PLK1, TTK phosphorylation +ITPR1 IP3R1 Channel, calcium; Channel, ligand-gated; Membrane protein, integral; Membrane protein, multi-pass Q14643 3708 3p26.1 human S1598-p 450681 RNAARRDsVLAASRD molecular association, regulation Calmodulin(DISRUPTS) 17696464 10 51 3 regulates calcium dependent binding +HIF1A HIF1A Autophagy; DNA-binding; Transcription factor Q16665 3091 14q23.2 human K477-sm 3656305 LNQEVALkLEPNPES protein stabilization transcription, induced; transcription, inhibited 15465032; 19680224 2 1 0 +Cdkn1c p57Kip2 iso2 Cell cycle regulation; Inhibitor; Nuclear receptor co-regulator; Tumor suppressor P49919-2 12577 7 F5|7 88.22 cM mouse T143-p 25525402 AEPTPPAtPAPASDL molecular association, regulation cell cycle regulation CDK2(INDUCES) 22569127 1 0 0 promotes cell survival upon osmostress +PPP1R12C PPP1R12C Protein phosphatase, regulatory subunit Q9BZL4 54776 19q13.42 human S452-p 472608 AGLQRSAsSSWLEGT molecular association, regulation 14-3-3 zeta(INDUCES) 22137581 2 28 41 mitotic progression +Rptor Raptor Adaptor/scaffold Q8K4Q0 74370 11|11 E2 mouse T706-p 11315002 ATEGGSLtPVRDSPC molecular association, regulation signaling pathway regulation PRAS40(INDUCES); p70S6K(INDUCES) 24239769 8 9 0 mechanical stress-induced mTOR signaling +RFC1 RFC1 DNA replication P35251 5981 4p14 human T76-p 26334306 SDSESEEtLQVKNAK enzymatic activity, induced 32907938 1 0 1 regulates ATPase activity of hRFC, it decreases in alanine mutation +Per1 PER1 Transcription factor O35973 18626 11|11 B3 mouse S714-p 465536 ALANKAEsVVSVTSQ phosphorylation 16750171 2 0 0 implicated in regulation of phosphorylation of other CK1epsilon sites +Gphn gephyrin Adaptor/scaffold; EC 2.10.1.1; EC 2.7.7.75 Q03555 64845 6q24 rat K756-sm 1876579504 EQYVELHkGEVVDVM MoeA_C molecular association, regulation gephyrin(DISRUPTS) 35307349 1 0 0 +BCAR1 P130Cas Adaptor/scaffold; Motility/polarity/chemotaxis P56945 9564 16q23.1 human Y12-p 4251353 NVLAKALyDNVAESP SH3_1 molecular association, regulation; intracellular localization; phosphorylation; enzymatic activity, induced carcinogenesis, induced; cell motility, induced; cell adhesion, inhibited PTP-PEST(DISRUPTS); FAK(DISRUPTS) 21937722 1 1 2 inhibits tyrosine phosphorylation, induces gelatinase activity +HIC1 HIC1 C2H2-type zinc finger protein; Transcription factor; Tumor suppressor Q14526 3090 17p13.3 human K333-sm 1910102 SLLYRWMkHEPGLGS molecular association, regulation DNA repair, induced; transcription, inhibited RBBP4(INDUCES); MTA1(INDUCES) 17283066; 20547755; 23417673 3 0 0 +PANX1 PANX1 Cell adhesion; Membrane protein, integral; Membrane protein, multi-pass Q96RD7 24145 11q21 human Y10-p 23129120 IAQLATEyVFSDFLL activity, induced carcinogenesis, induced; cell growth, induced 37056395 1 1 2 +NBN NBS1 Cell cycle regulation; DNA repair, damage O60934 4683 8q21.3 human K233-ac 487508 TFIFLNAkQHKKLSS NIBRIN_BRCT_II phosphorylation cell cycle regulation; apoptosis, induced; DNA repair, inhibited 17612497; 28869605 3 1 0 +HMGN1 HMGN1 DNA-binding; Nuclear receptor co-regulator P05114 3150 21q22.2 human S8-p 465531 MPKRKVSsAEGAAKE HMG14_17 intracellular localization 10739259 5 29 6 Phosphorylation facilitates localization to non-nuclear pools. +DROSHA DROSHA EC 3.1.26.3; Nucleolus; RNA processing; RNA-binding; Ribonuclease Q9NRR4 29102 5p13.3 human S355-p 30985044 LEIVNHRsPSREKKR molecular association, regulation DGCR8(DISRUPTS) 25699712 1 12 0 +DCK DCK EC 2.7.1.74; Kinase, other; Nucleotide Metabolism - purine; Nucleotide Metabolism - pyrimidine P27707 1633 4q13.3 human S74-p 456305 EFEELTMsQKNGGNV dNK activity, induced; molecular association, regulation; protein conformation; enzymatic activity, induced cell cycle regulation; DNA repair, induced; autophagy, induced; apoptosis, inhibited; signaling pathway regulation CDK1(INDUCES) 16361699; 17065079; 18258203; 20544527; 20637175; 21351740; 22490700; 22850745; 24462681; 25101980; 27879648; 29393406 16 28 92 IR induced autophagy +MECOM EVI1 C2H2-type zinc finger protein; Methyltransferase, protein lysine, predicted; Oncoprotein; Transcription regulation; Transcription, coactivator/corepressor Q03112 2122 3q26.2 human K752-ac 13362616 TTKRKDEkPLTPVPS molecular association, regulation DNA(INDUCES) 20363750 1 0 0 GATA-2 transcription induced +EZR Ezrin Cytoskeletal; Motility/polarity/chemotaxis P15311 7430 6q25.3 human S66-p 458400 LKLDKKVsAQEVRKE FERM_N molecular association, regulation; intracellular localization; protein conformation; phosphorylation exocytosis, induced; apoptosis, inhibited; cytoskeletal reorganization STX3(INDUCES); DDEFL1(INDUCES) 12840026; 16438931; 25301939; 26010871; 26405038; 28808054 8 1 0 important for cell secretion +METTL3 METTL3 EC 2.1.1.62; METHYLTRANSFERASE; Methyltransferase; RNA processing Q86U44 56339 14q11.2 human S50-p 3204585 SPTFRSDsPVPTAPT protein stabilization; molecular association, regulation; methylation carcinogenesis, induced; cell differentiation, induced USP5(DISRUPTS) 33217317 1 12 0 +WAS WASP Adaptor/scaffold; Motility/polarity/chemotaxis P42768 7454 Xp11.23 human Y102-p 60110900 LLWEQELySQLVYST WH1 protein degradation; molecular association, regulation carcinogenesis, induced; cell growth, induced WIPF1(DISRUPTS) 27694894 1 1 0 +Mapk8ip1 JIP1 Adaptor/scaffold Q9WVI9 19099 2|2 E1 mouse Y409-p 234613502 ESDSATVyDNCASAS molecular association, regulation Src iso1(INDUCES) 28930674 1 0 0 +Nrip1 RIP140 Nuclear receptor co-regulator; Transcription, coactivator/corepressor Q8CBD1 268903 16|16 C3.1 mouse K653-me 6742802 GEEQRPCkQLLSGNP NRIP1_repr_2 molecular association, regulation; methylation transcription, inhibited HDAC3(INDUCES) 19216533 1 1 0 inhibits arginine methylation +CPT2 CPT2 EC 2.3.1.21; Lipid Metabolism - fatty acid; Mitochondrial; Transferase P23786 1376 1p32.3 human K79-ac 1883486800 LNDGQFRkTEQFCKS acetylation 35728063 1 1 0 acetylation causes acylcarnitine accumulation cause mitochondrial damage in platelets and nucleated cells, blocking acylcarnitine generation with AMPK or CPT1 inhibitors, and SIRT3 agonists can induce platelet survival +AATF AATF Nucleolus; RNA-binding; Transcription factor Q9NY61 26574 17q12 human S321-p 460427 AGSEEISsEDDELVE AATF-Che1 acetylation chromatin organization, altered; cell growth, induced; transcription, induced H3(INDUCES) 34266450 1 53 7 induces histone acetylation +SKA3 SKA3 Cell cycle regulation Q8IX90 221150 13q12.11 human T217-p 3205641 MDDFECVtPKLEHFG molecular association, regulation; intracellular localization cell cycle regulation; chromatin organization, altered; cytoskeletal reorganization HEC1(INDUCES) 32491969 1 7 1 +Src Src iso1 EC 2.7.10.2; KINASE; Kinase, protein; Oncoprotein; Protein kinase, TK; Protein kinase, tyrosine (non-receptor) P05480-1 20779 2 H1|2 78.35 cM mouse Y535-p 448235 FTSTEPQyQPGENL_ molecular association, regulation; enzymatic activity, inhibited; enzymatic activity, induced transcription, inhibited; signaling pathway regulation; cell growth, altered Afadin(DISRUPTS); GRB2(INDUCES) 11713208; 17491594; 19147357; 21383697 153 24 968 transcription of miR-99a inhibited.; growth and transformation regulated through Cul5 +TACC3 TACC3 Cell cycle regulation F1NCL7 422899 chicken S569-p 41590808 GTSSFKEsALRKQSL intracellular localization 26134678 1 0 0 localization to the mitotic spindle +NPM/ALK NPM-ALK KINASE; Kinase, protein; Protein kinase, TK; Protein kinase, tyrosine (receptor) AAA58698 human Y156-p 27275109 MTDYNPNyCFAGKTS molecular association, regulation transcription, induced SNTB1(INDUCES); IRS1(INDUCES) 17086210; 17110082; 8633037 3 2 3 +TAB2 TAB2 Adaptor/scaffold Q9NYJ8 23118 6q25.1 human K329-sm 31089526 RKNQIEIkLEPPQRN molecular association, regulation signaling pathway regulation; transcription, inhibited 24096733; 33184450 2 0 0 inhibition of TRAF6/TAB2/TAK1 complex and downstream MAPK and NF-?B pathway +ARAF ARAF EC 2.7.11.1; KINASE; Kinase, protein; Oncoprotein; Protein kinase, Ser/Thr (non-receptor); Protein kinase, TKL P10398 369 Xp11.3 human T455-p 3306307 FGLATVKtRWSGAQP PK_Tyr_Ser-Thr enzymatic activity, induced 18662992 0 1 1 +H2BC3 H2B DNA-binding P33778 3018 6p22.2 human K120-ub 465519 EGTKAVTkYTSSK__ protein stabilization; molecular association, regulation; ubiquitination; intracellular localization; methylation; protein conformation carcinogenesis, induced; carcinogenesis, inhibited; cell growth, inhibited; transcription, induced; transcription, altered; DNA repair, induced; cell growth, induced; chromatin organization, altered; autophagy, inhibited; transcription, inhibited SMARCC1(INDUCES); USP44(DISRUPTS); SMARCA4(INDUCES); NBS1(INDUCES); SMARCB1(INDUCES); DOT1L(INDUCES); BRCA1(INDUCES) 16307923; 16713563; 21362548; 23933260; 26240340; 27132940; 32051583; 32076268; 32458023; 32934196; 35078192; 35172132; 35690146; 35739357; 36419136 35 21 138 Dot1L is recruited OGT to chromatin to enhance histone H2B S112 O-GlcNAc and increases H2B K120 ubiquitination; reduced ubiquitylation level indicated autophagy induction; polyubiquitylation at multiple sites including K120, and monoubiquitylation leads to activation of transcription, K11-linked and K11/K48-branched chains-active APC/C, accumulated at specific genes in mitotic hESCs co-occupied by WDR5 and TBP; p53 target genes including PPM1D, BTG2, PLK2, MDM2, p21Cip1 and PUMA, genes related to ERK/MAPK signalling; UBR7 monoubiquitinatesf histone H2BK120, which a?ects binding of H2BK120ub on Keap1 promoter inducing transcription; enrichment of H2Bk120 is associated with transcriptional elongation and gene expression levels following DNA damage; linc-RA1 stabilized the level of H2B K120 monoubiquitination, inhibiting the interaction of H2BK120 and USP44, which inhibits autophagy; inc-RA1 stabilizes the level of H2Bub1 by inhibiting the interaction between H2Bub1 and USP44, inhibiting autophagy; ubiquitin and nucleosome acidic patch binding by DOT1L are required for cell proliferation in a leukemia model +ETV5 ERM DNA-binding; Transcription factor P41161 2119 3q27.2 human K263-sm 2887208 PPPPQGFkQEYHDPL ETS_PEA3_N transcription, inhibited 15857832; 18243147 2 0 0 +GAREM2 FAM59B Unknown function Q75VX8 150946 2p23.3 human Y551-p 28850310 SPDTYSLyCYPCTWG molecular association, regulation cell differentiation, induced; signaling pathway regulation GRB2(INDUCES) 24003223 1 0 0 +Ripk3 RIPK3 EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, Ser/Thr (non-receptor); Protein kinase, TKL Q9QZL0 56532 14|14 C3 mouse T231-p 27928506 EAELVDKtSLIRETV Pkinase molecular association, regulation; intracellular localization; protein conformation; phosphorylation apoptosis, induced; apoptosis, inhibited MLKL(INDUCES) 23612963; 24902902; 25459880; 31511692; 35648750 13 2 0 +Ppargc1b PGC-1 beta Nuclear receptor co-regulator; Transcription, coactivator/corepressor Q8VHJ7 170826 18|18 E1 mouse K230-ac 7761205 VLPCPRVkACSPTPH intracellular localization transcription, inhibited 19491097 1 1 0 +PKM PKM Carbohydrate Metabolism - glycolysis and gluconeogenesis; Carbohydrate Metabolism - pyruvate; EC 2.7.1.40; KINASE; Kinase, other; Mitochondrial; Nucleotide Metabolism - purine P14618 5315 15q23 human S406-gl 394791403 RRLAPITsDPTEATA molecular association, regulation; intracellular localization; protein conformation; phosphorylation cell growth, induced ERK2(INDUCES); ERK1(INDUCES) 29229835 2 1 0 promotes Warburg effect and cell proliferation, tumor growth, disassociation of the PKM2 tetramer ; nuclear translocation +SLC30A2 SLC30A2 Membrane protein, integral; Membrane protein, multi-pass; Transporter; Transporter, SLC family Q9BRI3 7780 1p36.11 human S296-p 40413916 AVRDLLLsVEGVEAL intracellular localization 25808614 1 0 0 ZnT2 targeted to lysosome, lysosomal-mediated cell death (LCD) +SFTPC SFTPC Lipid-binding P11686 6440 8p21.3 human K6-ub 9381808 __MDVGSkEVLMESP SP_C-Propep protein processing endocytosis, induced 19423771 1 0 0 processing of proSFTPC to mature peptide +PRKCQ PKCT EC 2.7.11.13; KINASE; Kinase, protein; Protein kinase, AGC; Protein kinase, Ser/Thr (non-receptor) Q04759 5588 10p15.1 human T538-p 447907 LGDAKTNtFCGTPDY Pkinase enzymatic activity, induced carcinogenesis, inhibited; autophagy, induced; cell growth, inhibited; signaling pathway regulation; transcription, altered 11772397; 16252004; 21983831; 35403545 17 7 23 +Yap1 YAP1 Oncoprotein; Transcription, coactivator/corepressor P46938 22601 9|9 A1 mouse T48-p 484117 HVRGDSEtDLEALFN intracellular localization carcinogenesis, induced; cell differentiation, induced; transcription, induced 33574090 2 23 0 +Psen1 PSEN1 Cell surface; EC 3.4.23.-; Membrane protein, integral; Membrane protein, multi-pass; Mitochondrial; Protease P49769 19164 12 D1|12 38.84 cM mouse S367-p 454173 AVQELSGsILTSEDP Presenilin molecular association, regulation autophagy, induced ANXA2(INDUCES) 28533411 2 47 3 +CDC34 CDC34 EC 6.3.2.19; Ligase; UBIQUITIN LIGASE; Ubiquitin conjugating system; Ubiquitin ligase P49427 997 19p13.3 human T233-p 448689 DDEDDSGtEES____ intracellular localization 11546811 2 0 0 +Pik3r2 PIK3R2 Kinase, lipid; Motility/polarity/chemotaxis O08908 18709 8 B3.3|8 34.15 cM mouse Y458-p 449572 SREYDQLyEEYTRTS PI3K_P85_iSH2 carcinogenesis, induced; autophagy, induced; cell motility, induced; transcription, induced 22388104; 34706731 10 55 1664 +PSEN2 PSEN2 Cell surface; EC 3.4.23.-; Membrane protein, integral; Membrane protein, multi-pass; Protease P49810 5664 1q42.13 human S330-p 448567 MEEDSYDsFGEPSYP Presenilin; Presenilin protein stabilization apoptosis, inhibited 9990034 2 0 0 Phosphorylation of Presenilin 2 inhibits its cleavage by caspase-3. +ADRA2A ADRA2A GPCR, family 1; Membrane protein, integral; Membrane protein, multi-pass; Receptor, GPCR P08913 150 10q25.2 human S312-p 456350 ALDLEESsSSDHAER 7tm_1 activity, inhibited 7876239 1 2 0 +Lhcgr LHR GPCR, family 1; Membrane protein, integral; Membrane protein, multi-pass; Receptor, GPCR P16235 25477 6q12 rat S665-p 451063 KEFSAYTsNCKNGFP receptor internalization, altered 9660797 1 0 0 S665 is required for agonist-induced uncoupling and internalization. +ORC2 ORC2 DNA replication Q13416 4999 2q33.1 human T116-p 3195386 LASELAKtPQKSVSF molecular association, regulation cell cycle regulation DNA(DISRUPTS) 22334659; 24732362 3 17 15 +Tbxa2r TXA2-R GPCR, family 1; Membrane protein, integral; Membrane protein, multi-pass; Receptor, GPCR P30987 21390 10 C1|10 39.72 cM mouse T226-p 3061801 TLCRVYHtREATQRP 7tm_1 receptor desensitization, altered 12428680 1 0 0 GRK2 mediated but not PKC +BRAF BRAF EC 2.7.11.1; KINASE; Kinase, protein; Oncoprotein; Protein kinase, Ser/Thr (non-receptor); Protein kinase, TKL P15056 673 7q34 human S365-p 450243 GQRDRSSsAPNVHIN molecular association, regulation; enzymatic activity, inhibited transcription, induced; cell growth, altered 14-3-3 beta(INDUCES) 10869359; 11293329; 18451171; 37625591 9 27 30 +Akt1s1 PRAS40 Apoptosis D3ZH75 292887 1q22 rat T247-p 470067 LPRPRLNtSDFQKLK PRAS molecular association, regulation TORC1(DISRUPTS) 20484410 50 69 781 +GTF2F1 GTF2F1 EC 2.7.11.1; KINASE; Kinase, protein; Transcription initiation complex P35269 2962 19p13.3 human S385-p 483594 GGSSRGNsRPGTPSA TFIIF_alpha activity, inhibited transcription, inhibited 10428810 1 52 231 slows down RNA pol II elongation +MAPK14 P38A EC 2.7.11.24; KINASE; Kinase, protein; Protein kinase, CMGC; Protein kinase, Ser/Thr (non-receptor) Q16539 1432 6p21.31 human Y323-p 455799 DEPVADPyDQSFESR phosphorylation; enzymatic activity, induced 15735648 8 1 0 +Bcl2 Bcl-2 Apoptosis; Autophagy; Membrane protein, integral; Oncoprotein P10417 12043 1 E2.1|1 49.76 cM mouse S70-p 448395 RDMAARTsPLRPLVA protein stabilization; molecular association, regulation; phosphorylation cell cycle regulation; autophagy, induced; cell growth, induced; cell differentiation, induced; apoptosis, inhibited BAX(INDUCES); beclin 1(DISRUPTS) 10677502; 11323415; 14660795; 18463240; 32051584; 35183115; 35702893; 37179010; 9115213 49 1 0 +Axin1 axin 1 Adaptor/scaffold; Tumor suppressor O70239 79257 10q12 rat T480-p 451091 HVQRVMRtPGCQSPG Axin_b-cat_bind cytoskeletal reorganization 22933777 5 6 0 Phosphorylation regulates responsive to Sema3A induced growth cone collapse. +PTPN11 SHP-2 iso1 EC 3.1.3.48; Motility/polarity/chemotaxis; PHOSPHATASE; Protein phosphatase, tyrosine (non-receptor) Q06124-1 5781 12q24.13 human T73-p 40407604 YGGEKFAtLAELVQY SH2 molecular association, regulation; enzymatic activity, inhibited; phosphorylation GAB1(DISRUPTS); GAB2(DISRUPTS); PRKD1(DISRUPTS) 25802336 1 0 0 enhances phosphorylation of PKD1 +FURIN FURIN Cell surface; EC 3.4.21.75; Membrane protein, integral; Protease; Vesicle P09958 5045 15q26.1 human S775-p 469743 QEECPSDsEEDEGRG intracellular localization 8846780 2 9 0 retrieval to the trans-Golgi network +ATM ATM DNA repair, damage; EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, Ser/Thr (non-receptor); Protein kinase, atypical; Tumor suppressor Q13315 472 11q22.3 human Y370-p 38535268 SLEISQSyTTTQRES enzymatic activity, induced 25601159 1 1 0 facilitates its activation upon IR treatment +STK11 LKB1 Autophagy; EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, CAMK; Protein kinase, Ser/Thr (non-receptor); Tumor suppressor Q15831 6794 19p13.3 human T402-p 11454702 TEAAQLStKSRAEGR enzymatic activity, induced 12805220 1 0 0 STRAD increases LKB1 activation +Dzip1 DZIP1 C2H2-type zinc finger protein Q8BMD2 66573 14|14 E4 mouse S706-p 21241901 FGKSAVKsDTDWTEG transcription, induced; signaling pathway regulation 21878643 1 0 0 involved in Gli1 nad Gli3 turnover pathway +SLC2A1 GLUT1 Membrane protein, integral; Membrane protein, multi-pass; Transporter; Transporter, SLC family P11166 6513 1p34.2 human S490-p 477830 FHPLGADsQV_____ activity, induced; molecular association, regulation; intracellular localization carcinogenesis, induced; cell motility, induced; translation, induced; signaling pathway regulation GIPC1(INDUCES) 23776597; 30799198 2 16 49 Increased glucose and DHA transport, increased cell surface expression of GLUT1; induce PKM2 activation and glycolysis +Chuk IKKA EC 2.7.11.10; KINASE; Kinase, protein; Protein kinase, Other; Protein kinase, Ser/Thr (non-receptor) Q60680 12675 19 C3|19 36.71 cM mouse S180-p 447779 DQGSLCTsFVGTLQY Pkinase enzymatic activity, induced cell differentiation, inhibited; apoptosis, altered; apoptosis, induced; transcription, altered; cell growth, altered 15935065; 18497757; 35449211; 35637461 44 0 0 +ICAM3 ICAM3 Cell adhesion; Immunoglobulin superfamily; Membrane protein, integral P32942 3385 19p13.2 human S516-p 451212 VFREHQRsGSYHVRE intracellular localization 11784723 1 0 1 +TEK TIE2 EC 2.7.10.1; KINASE; Kinase, protein; Membrane protein, integral; Protein kinase, TK; Protein kinase, tyrosine (receptor) Q02763 7010 9p21.2 human Y1108-p 448372 TYVNTTLyEKFTYAG enzymatic activity, induced 20973951 4 0 1 +LILRB2 LILRB2 Membrane protein, integral; Receptor, misc. Q8N423 10288 19q13.42 human Y591-p 464930 PPAEPSIyATLAIH_ molecular association, regulation CSK(INDUCES); SHP-1(INDUCES) 11907092; 15474475 2 0 1 Mutation of Y533 prevented binding in vivo. +AQP4 AQP4 iso4 Channel, misc.; Membrane protein, integral; Membrane protein, multi-pass; Transporter; Transporter, aquaporin family A0A5F9ZHR4 361 18q11.2 human S331-p 1877492100 XLEDRTEsRQDSLEL intracellular localization 35625560 1 0 0 +ZBTB16 PLZF C2H2-type zinc finger protein; DNA-binding; Oncoprotein; Transcription, coactivator/corepressor Q05516 7704 11q23.2 human K242-sm 2303904 HPGVAEVkTEMMQVD protein stabilization; molecular association, regulation; ubiquitination; intracellular localization cell cycle regulation; cell growth, inhibited; apoptosis, inhibited; transcription, inhibited DNA(INDUCES) 14527952; 17498654; 18348865; 18396468 4 0 0 nuclear localization, inhibits ubiquitination; nuclear localization +PDP1 PDP1 EC 3.1.3.43; Mitochondrial; Motility/polarity/chemotaxis; PHOSPHATASE; Protein phosphatase, Ser/Thr (non-receptor) Q9P0J1 54704 8q22.1 human Y381-p 15422118 DQLNDNEyTKFIPPN PP2C molecular association, regulation SIRT3(DISRUPTS); ACAT1(INDUCES) 24486017 2 1 0 +SLC6A12 SLC6A12 Membrane protein, integral; Membrane protein, multi-pass; Transporter; Transporter, SLC family P27799 404013 dog T612-p 454881 LIVGEKEtHL_____ molecular association, regulation; phosphorylation LIN7C(DISRUPTS) 15591048 1 0 0 +MARK2 MARK2 EC 2.7.11.1; EC 2.7.11.26; KINASE; Kinase, protein; Protein kinase, CAMK; Protein kinase, Ser/Thr (non-receptor) Q7KZI7 2011 11q13.1 human S619-p 455400 PYGVTPAsPSGHSQG cell cycle regulation; carcinogenesis, induced; apoptosis, inhibited 35780183 1 34 102 +THEM4 CTMP EC 3.1.2.2; Mitochondrial Q5T1C6 117145 1q21.3 human S37-p 9721501 RPELRSFsSEEVILK intracellular localization 19604401 1 1 0 +MOK MOK EC 2.7.11.22; KINASE; Kinase, protein; Protein kinase, CMGC; Protein kinase, Ser/Thr (non-receptor) Q9UQ07 5891 14q32.31 human T159-p 450005 VYSKQPYtEYISTRW Pkinase activity, induced 10421840 1 1 0 While the authors did not prove that these sites were phosphorylated, mutation of both T159 and Y161, located in the activation loop, abolished the enzymatic activity of the kinase. +Nfatc4 NFAT3 DNA-binding; Transcription factor Q8K120 73181 14|14 C3 mouse S170-p 448860 GGAFFSPsPGSSSLS intracellular localization; activity, inhibited transcription, altered 18347059; 18691762; 27307045 7 0 1 +TBK1 TBK1 EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, Other; Protein kinase, Ser/Thr (non-receptor) Q9UHD2 29110 12q14.2 human K692-ac 1881543100 EMTLGMKkLKEEMEG molecular association, regulation TBK1(DISRUPTS) 32772249 1 1 0 dimerization- effect of K692A,D mutants +Traf6 TRAF6 EC 6.3.2.-; Ligase; UBIQUITIN LIGASE; Ubiquitin conjugating system; Ubiquitin ligase P70196 22034 2|2 E2 mouse T471-p 40240800 LLAFQRPtIPRNPKG ubiquitination; protein conformation transcription, inhibited 25642822 1 0 0 prevent its oligomerization and autoubiquitination, inhibits LPS-stimulated transcription of Tnf and Il6 +NME1 NME1 EC 2.7.4.6; KINASE; Kinase, nucleoside diphosphate; Kinase, other; Nucleotide Metabolism - purine; Nucleotide Metabolism - pyrimidine; Protein kinase, histidine; Tumor suppressor P15531 4830 17q21.33 human S44-p 450096 GLKFMQAsEDLLKEH NDK cell growth, altered 12859952 4 1 1 inhibits colony formation in soft agar +Hist1h2ail1 H3 DNA-binding Q6LED0 291159 17p11 rat S28-p 455677 ATKAARKsAPATGGV Histone transcription, induced 22025646 50 18 0 at c-Jun and PAI gene promoters +Amph amphiphysin Vesicle Q7TQF7 218038 13 A2|13 6.89 cM mouse T260-p 3147510 GPLRIAKtPSPPEEP endocytosis, altered 18761055 1 8 1 +NUMA1 NuMA-1 Cell cycle regulation; Motility/polarity/chemotaxis Q14980 4926 11q13.4 human S2047-p 4748253 KQADRRQsMAFSILN intracellular localization cell growth, induced; apoptosis, inhibited 23097092 3 26 2 cell proliferation increased +Mpl MPL Membrane protein, integral; Receptor, cytokine Q08351 17480 4 D2.1|4 54.61 cM mouse S568-p 3091405 ILPKSSEsTPLPLCP activity, induced; phosphorylation cell growth, altered 10918061 1 0 0 tyrosine phosphorylation of JAK2 +Ctnnd1 CTNND1 Actin-binding; Adaptor/scaffold; Cell adhesion; G protein regulator, misc.; Motility/polarity/chemotaxis P30999 12388 2 D|2 49.45 cM mouse S268-p 450453 PQVRVGGsSVDLHRF molecular association, regulation cell adhesion, inhibited 26175155; 26845024 12 73 56 310A and 268A mutants showed clumping, overall phosphorylation regulates activity; decreased homophilic binding affinity of E-cadherin +RCAN1 RCAN1 iso2 Inhibitor P53805-2 1827 21q22.12 human S93-p 25687504 AQTLHIGsSHLAPPN Calcipressin protein stabilization transcription, inhibited 25753203 3 2 0 enhances the inhibition of calcineurin activity +KCNA3 Kv1.3 Channel, potassium; Membrane protein, integral; Membrane protein, multi-pass P22001 3738 1p13.3 human S511-p 4703603 SCQHLSSsAEELRKA cell growth, induced 26655221 1 1 1 +CASQ2 calsequestrin 2 Calcium-binding P12637 483134 dog S401-p 451475 GNNSDEEsNDDSDDD intracellular localization 21431367 2 1 0 regulates intracellular trafficking of calsequestrin 2 +Gja4 GJA4 Cell adhesion; Membrane protein, integral; Membrane protein, multi-pass P28235 14612 4 D2.2|4 61.47 cM mouse S275-p 1867850300 PMGEGPSsPPCPTYN protein conformation apoptosis, induced; apoptosis, inhibited 30736283 1 0 0 intramolecular interaction between the mid- and the end-tail of GJA4; at low cells density; at high cells density +HDAC9 HDAC9 DEACETYLASE; Deacetylase; EC 3.5.1.98; Transcription, coactivator/corepressor Q9UKV0 9734 7p21.1 human S253-p 13204427 KDGNVVTsFKKRMFE intracellular localization 20188095 1 0 0 +NR3C2 MCR DNA-binding; Nuclear receptor P08235 4306 4q31.23 human S287-p 4767239 SVKSPVSsPNNVTLR protein degradation; ubiquitination transcription, inhibited 22798426 1 5 0 +GAB2 GAB2 Adaptor/scaffold Q9UQC2 9846 11q14.1 human S159-p 448382 LLRERKSsAPSHSSQ molecular association, regulation cell growth, altered HER2(DISRUPTS); SHC1(DISRUPTS) 11782427 3 1 0 Introduction of the S159A mutation markedly enhanced HRG-stimulated tyrosine phosphorylation of Gab2. A global amplification of HRG-induced tyrosine phosphorylation was observed in cells expressing S159A Gab2. +DGCR8 DGCR8 Nucleolus; RNA processing; RNA-binding Q8WYQ5 54487 22q11.21 human S280-p 14572439 HPSDGETsVQPMMTK protein stabilization 24239349 0 2 1 +NEDD4 NEDD4 EC 6.3.2.-; EC 6.3.2.19; Ligase; Nuclear receptor co-regulator; UBIQUITIN LIGASE; Ubiquitin conjugating system; Ubiquitin ligase P46934 4734 15q21.3 human K1279-ub 1877089302 EQWGTPEkLPRAHTC HECT protein stabilization; molecular association, regulation autophagy, induced USP13(INDUCES); PIK3C3(INDUCES) 32101753 1 0 0 autoregulated K29 linked ubiquitination required for interaction with USP13 and VPS34, deubiquitination and stabilization of VPS3, deubiquitination and stabilization of VPS34, promoting the formation of autophagosomes +ARHGAP18 ARHGAP18 GAP; GAP, Rac/Rho Q8N392 93663 6q22.33 human T158-p 4760950 RVETVSQtLRKKNKQ cytoskeletal reorganization 25456499 1 6 2 spine development +EGFR EGFR EC 2.7.10.1; KINASE; Kinase, protein; Membrane protein, integral; Oncoprotein; Protein kinase, TK; Protein kinase, tyrosine (receptor) P00533 1956 7p11.2 human Y1125-p 449795 APSRDPHyQDPHSTA molecular association, regulation GRB2(INDUCES) 16729043 5 1 40 +WWTR1 TAZ Oncoprotein; Transcription, coactivator/corepressor Q9GZV5 25937 3q25.1 human S90-p 4777166 QHVRSHSsPASLQLG protein degradation; activity, inhibited carcinogenesis, inhibited; cell growth, inhibited; cell motility, inhibited; transcription, inhibited 26183396; 26375055 2 6 14 +UVRAG UVRAG Autophagy Q9P2Y5 7405 11q13.5 human S550-p 4761506 KITSLSSsLDTSLDF enzymatic activity, induced 26139536 2 22 0 alters lysosomal morphology and lysosomal tubulation +EIF2AK2 PKR EC 2.7.10.2; EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, Other; Protein kinase, Ser/Thr (non-receptor); Protein kinase, tyrosine (non-receptor); Translation P19525 5610 2p22.2 human S456-p 3181637 KGTLRYMsPEQISSQ Pkinase carcinogenesis, induced; cell motility, induced; cell growth, induced; apoptosis, inhibited 34799660 1 5 0 +PTPN6 SHP-1 EC 3.1.3.48; Motility/polarity/chemotaxis; PHOSPHATASE; Protein phosphatase, tyrosine (non-receptor) P29350 5777 12p13.31 human Y536-p 448506 QKGQESEyGNITYPP molecular association, regulation; enzymatic activity, induced cell motility, induced; cell growth, induced; transcription, induced; cell adhesion, inhibited; transcription, inhibited; signaling pathway regulation GRB2(INDUCES) 12468540; 14551136; 14699166; 17675340; 18377662; 21900501; 28692056; 34010642 20 24 637 +CAPZA1 CAPZA1 Actin-binding; Motility/polarity/chemotaxis P52907 829 1p13.2 human S106-p 27445584 DHLRKEAsDPQPEEA F-actin_cap_A cell motility, induced; cell adhesion, induced; cytoskeletal reorganization 32771000 1 5 0 +Gnaq G-alpha(q) G protein; G protein, heterotrimeric; G protein, heterotrimeric alpha G(q) P21279 14682 19 A|19 11.01 cM mouse Y356-p 449722 LQLNLKEyNLV____ activity, induced mAChR m1(NOT_REPORTED) 9188537 2 0 2 +TCF4 TCF4 DNA-binding; Transcription factor P15884 6925 18q21.2 human S56-p 451216 NVEDRSSsGSWGNGG molecular association, regulation transcription, induced CTNNG(DISRUPTS) 11711551 1 0 0 +IL1RL1 IL1RL1 Membrane protein, integral; Receptor, cytokine Q01638 9173 2q12.1 human K511-ub 1883430200 MKVQGTIkWREDHIA protein stabilization; phosphorylation transcription, induced; signaling pathway regulation 35238669 1 0 0 Il-33?induced phosphorylation, induction of downstream inflammatory genes +PTEN PTEN Carbohydrate Metabolism - inositol phosphate; EC 3.1.3.16; EC 3.1.3.48; EC 3.1.3.67; Motility/polarity/chemotaxis; Nuclear receptor co-regulator; PHOSPHATASE; Phosphatase, lipid; Tumor suppressor P60484 5728 10q23.31 human K80-ub 27205464 ERHYDTAkFNCRVAQ ubiquitination 30631154 3 5 0 PTEN dephosphorylates master regulators of EMT in vivo; K27-linked polyubiquitination alters PTEN substrate binding; converted PTEN from a phosphoinositide/protein tyrosine phosphatase to a protein serine/threonine phosphatase +Bcl2l11 BIM Apoptosis O54918 12125 2|2 F1 mouse S105-p 471329 DRSPAPMsCDKSTQT protein degradation apoptosis, inhibited 17105963 1 0 0 +Kcnq2 Kv7.2 Channel, potassium; Membrane protein, integral; Membrane protein, multi-pass O88943 170848 3q43 rat S541-p 11082901 SKRKFKEsLRPYDVM KCNQ_channel activity, induced; molecular association, regulation Calmodulin(DISRUPTS) 12754513; 22643219 3 0 0 reduces the affinity with PIP2; Mutants showed reduced currents induced by acetylcholine. +BRD4 BRD4 KINASE; Kinase, protein; Protein kinase, Ser/Thr (non-receptor); Protein kinase, atypical O60885 23476 19p13.12 human K99-me 1881502504 LNLPDYYkIIKTPMD molecular association, regulation transcription, induced; transcription, inhibited; translation, inhibited E2F1(INDUCES) 34039605; 36300937 2 1 0 HPV transcriptional activation; inhibits the expression of genes involved in mRNA translation, translation?related target genes +Nkx2-1 NKX2-1 Cell development/differentiation; DNA-binding; Transcription factor P50220 21869 12 C1|12 24.42 cM mouse S23-p 21478902 ILSPLEEsYKKVGME molecular association, regulation carcinogenesis, induced; cell growth, induced; transcription, induced DNA(INDUCES) 36194647 2 1 0 +Grb10 GRB10 Adaptor/scaffold Q60760 14783 11 A1|11 7.15 cM mouse S455-p 455333 NAPMRSVsENSLVAM BPS molecular association, regulation 14-3-3 eta(INDUCES) 15722337 2 8 0 +NF1 NF1 iso2 GAP; GAP, Ras; Motility/polarity/chemotaxis; Nucleolus; Tumor suppressor P21359-2 4763 17q11.2 human S2576-p 456014 HPHLRKVsVSESNVL molecular association, regulation; activity, inhibited 14-3-3 beta(INDUCES) 14741381 1 18 10 +ITGB7 ITGB7 Cell adhesion; Membrane protein, integral; Motility/polarity/chemotaxis; Receptor, misc. P26010 3695 12q13.13 human T783-p 450186 PLYKSAItTTINPRF Integrin_b_cyt molecular association, regulation FLNA(DISRUPTS) 16455489 2 0 0 based on glutamate mutant of threonine site +EPHA4 EphA4 EC 2.7.10.1; KINASE; Kinase, protein; Membrane protein, integral; Protein kinase, TK; Protein kinase, tyrosine (receptor) P54764 2043 2q36.1 human Y596-p 450856 LNQGVRTyVDPFTYE EphA2_TM enzymatic activity, induced 21439481 5 14 75 +TBC1D4 AS160 GAP; GAP, Rab O60343 9882 13q22.2 human T642-p 455921 QFRRRAHtFSHPPSS molecular association, regulation endocytosis, induced; signaling pathway regulation 14-3-3 beta(INDUCES); 14-3-3 theta(INDUCES); 14-3-3 epsilon(INDUCES) 16880201; 17617058; 20410134; 26465605 45 21 134 albumin endocytosis; multiple sites (6P) mutant +TRIM65 TRIM65 Ubiquitin conjugating system Q6PJ69 201292 17q25.1 human S181-p 1871608302 CILASWVsGKFSSLL carcinogenesis, inhibited; signaling pathway regulation 31332286 1 1 0 dephosphorylated form (6A mutant) contributes to TRIM65 function in tumor progression +Prkcb PKCB EC 2.7.11.13; KINASE; Kinase, protein; Motility/polarity/chemotaxis; Protein kinase, AGC; Protein kinase, Ser/Thr (non-receptor) P68403 25023 1q36 rat T635-p 1869073012 SNFDKEFtRQPVELT Pkinase_C intracellular localization; enzymatic activity, induced transcription, altered 8327493 3 0 0 increases expression of c-Fos and c-Jun +Lpxn leupaxin Adaptor/scaffold; Cytoskeletal; Motility/polarity/chemotaxis Q99N69 107321 19|19 A mouse Y72-p 449706 NIQEPNVySEVQEPK activity, induced 17640867 2 2 48 important for laupaxin-mediated repression of BCR-induced IL-2 production +MAP3K2 MEKK2 EC 2.7.11.25; KINASE; Kinase, protein; Protein kinase, STE; Protein kinase, Ser/Thr (non-receptor) Q9Y2U5 10746 2q14.3 human T522-p 1904500 GTGMKSVtGTPYWMS Pkinase phosphorylation; enzymatic activity, induced transcription, altered 16362041 1 1 0 Mutation of S520A inhibits activation and is the key residue. Double mutation of T522A,T524A reduces activation effect. T522A seems to have the least effect of the three single mutations. The triple STT to AAA mutation is akin to kinase dead. Activation leads to Erk5 and JNKK2 phosphorylation/activation. +Mlf2 MLF2 Cell adhesion Q99KX1 30853 6|6 F2 mouse S28-p 13261776 AIHRQHMsRMLSGGF Mlf1IP activity, induced carcinogenesis, induced; cell growth, induced 31831854 1 2 0 +PTPN12 PTP-PEST EC 3.1.3.48; Motility/polarity/chemotaxis; PHOSPHATASE; Protein phosphatase, tyrosine (non-receptor) Q05209 5782 7q11.23 human S571-p 1983755 KTVSLTPsPTTQVET molecular association, regulation; phosphorylation carcinogenesis, induced; cell motility, induced; cell adhesion, inhibited FAK(INDUCES); PIN1(INDUCES) 21876001 1 13 3 induces dephosphorylation of FAK +Map3k11 MLK3 EC 2.7.11.25; KINASE; Kinase, protein; Protein kinase, Ser/Thr (non-receptor); Protein kinase, TKL Q80XI6 26403 19 A|19 4.34 cM mouse T278-p 448263 LAREWHKtTQMSAAG PK_Tyr_Ser-Thr enzymatic activity, induced 34324442 8 0 0 +AFF1 AF-4 Oncoprotein; Transcription factor P51825 4299 4q21.3-q22.1 human T220-p 3191677 PIHSNQQtLPRTQGS AF-4 protein degradation; molecular association, regulation; intracellular localization transcription, induced 14-3-3 theta(INDUCES); CDK9(INDUCES) 21574958 1 3 1 nuclear import-export +SATB2 SATB2 DNA-binding Q9UPW6 23314 2q33.1 human K233-sm 2894437 YKKYKKIkVERVERE CUTL molecular association, regulation; intracellular localization transcription, inhibited DNA(DISRUPTS) 14701874 1 0 0 +AGO2 AGO2 EC 3.1.26.n2; RNA processing; RNA-binding Q9UKV8 27161 8q24.3 human K402-sm 34823402 REFGIMVkDEMTDVT ArgoL2 protein degradation 25036361 1 0 0 +FGR FGR EC 2.7.10.2; KINASE; Kinase, protein; Mitochondrial; Oncoprotein; Protein kinase, TK; Protein kinase, tyrosine (non-receptor) P09769 2268 1p35.3 human Y412-p 448120 RLIKDDEyNPCQGSK PK_Tyr_Ser-Thr carcinogenesis, induced; DNA repair, induced 29989005 4 8 197 +STK4 MST1 Autophagy; EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, STE; Protein kinase, Ser/Thr (non-receptor) Q13043 6789 20q13.12 human T367-p 7445972 TLPSQLGtMVINAED molecular association, regulation MOB1A(INDUCES); MST1(DISRUPTS) 28373297; 28373298 2 3 0 fluorescence polarization +NDRG1 NDRG1 Cell development/differentiation; Vesicle Q92597 10397 8q24.22 human S330-p 452879 LMRSRTAsGSSVTSL protein degradation; molecular association, regulation; intracellular localization; phosphorylation carcinogenesis, induced; carcinogenesis, inhibited; carcinogenesis, altered; cell motility, induced; transcription, induced AR(DISRUPTS) 20416281; 21719465; 33398037 10 74 485 +MAPT Tau iso3 ACETYLTRANSFERASE; Acetyltransferase; Cytoskeletal P10636-3 4137 17q21.31 human S108-p 447928 SGYSSPGsPGTPGSR molecular association, regulation cytoskeletal reorganization 10747907 175 57 116 regulates association with membrane +NR5A1 STF-1 Nuclear receptor; Transcription, coactivator/corepressor Q13285 2516 9q33.3 human K119-sm 2798301 QIRANGFkLETGPPM molecular association, regulation; intracellular localization transcription, inhibited PITX1(DISRUPTS); RAD54L2(INDUCES) DNA(INDUCES) 15192092; 19692572; 19995909 7 0 0 +RET Ret EC 2.7.10.1; KINASE; Kinase, protein; Membrane protein, integral; Oncoprotein; Protein kinase, TK; Protein kinase, tyrosine (receptor) P07949 5979 10q11.21 human Y806-p 450700 PLLLIVEyAKYGSLR PK_Tyr_Ser-Thr enzymatic activity, induced cell growth, altered 14711813 1 0 0 +CD79B Ig-beta Membrane protein, integral; Receptor, misc. P40259 974 17q23.3 human Y196-p 459286 GMEEDHTyEGLDIDQ phosphorylation signaling pathway regulation 37467575 2 1 5 inhibits DOCK8 phosphorylation, regulates BCR signaling +ACBD4 ACBD4 Lipid-binding Q8NC06 79777 17q21.31 human S183-p 1876128604 DSEVFCDsLEQLEPE molecular association, regulation VAPB(DISRUPTS) 35019937 1 0 0 +ADD1 ADD1 Cytoskeletal; Motility/polarity/chemotaxis P35611 118 4p16.3 human S726-p 449829 KKKFRTPsFLKKSKK molecular association, regulation; intracellular localization cell cycle regulation; carcinogenesis, induced; endocytosis, induced; cell motility, induced; cytoskeletal reorganization TPX2(INDUCES) 15910744; 17341583; 21736685; 23349050; 29925526; 31548578; 9679146 24 57 158 +Mfn1 MFN1 EC 3.6.5.-; Hydrolase; Membrane protein, integral; Membrane protein, multi-pass; Mitochondrial Q8R4Z9 192647 2q24 rat S86-p 1498941800 AFFGRTSsGKSSVIN Dynamin_N enzymatic activity, inhibited apoptosis, induced 30659190 1 1 0 +MAF1 MAF1 Transcription regulation Q9H063 84232 8q24.3 human T64-p 3211923 EALSPPQtSGLSPSR Maf1 transcription, induced 20233713 1 4 1 +ANXA1 ANXA1 Calcium-binding; Lipid-binding P04083 301 9q21.13 human T24-p 452052 EEQEYVQtVKSSKGG molecular association, regulation ACTB(INDUCES) 27634935 2 0 0 +Mark1 MARK1 EC 2.7.11.1; EC 2.7.11.26; KINASE; Kinase, protein; Protein kinase, CAMK; Protein kinase, Ser/Thr (non-receptor) O08678 117016 13q26 rat T215-p 456037 TVGNKLDtFCGSPPY Pkinase enzymatic activity, induced 9108484 4 45 33 +Nono NONO Nuclear receptor co-regulator; Nucleolus; RNA splicing; RNA-binding Q99K48 53610 X|X D mouse T15-p 18013091 NLEKQNHtPRKHHQH molecular association, regulation RNA(DISRUPTS) 21819346 1 3 15 except G-rich RNA +ERRFI1 MIG-6 Inhibitor; Tumor suppressor Q9UJM3 54206 1p36.23 human S251-p 3215403 RRLRRSHsGPAGSFN activity, induced; phosphorylation signaling pathway regulation; cell growth, altered 22505024 3 41 39 EGF-signaling, EGFR autophosphorylation enhanced +HDAC1 HDAC1 DEACETYLASE; Deacetylase; EC 3.5.1.98; Hydrolase; Nuclear receptor co-regulator Q13547 3065 1p35.2-p35.1 human K220-ac 4219802 DIGAGKGkYYAVNYP Hist_deacetyl enzymatic activity, inhibited transcription, inhibited 16762839 1 2 5 +CHMP4C CHMP4C Vesicle Q96CF2 92421 8q21.13 human S215-p 1221009 RRSRAASsQRAEEED cell cycle regulation 22724069 2 1 22 mutations of site increase cytokinesis failure +Tpt1 TPT1 Calcium-binding; Microtubule-binding P63028 22070 14 D3|14 40.29 cM mouse S46-p 476067 TEGAIDDsLIGGNAS TCTP phosphorylation cell cycle regulation; apoptosis, altered; cytoskeletal reorganization 12167714 8 11 9 +GRK1 GRK1 EC 2.7.11.14; KINASE; Kinase, protein; Protein kinase, AGC; Protein kinase, Ser/Thr (non-receptor) Q15835 6011 13q34 human T492-p 2530400 QDVGAFStVKGVAFD molecular association, regulation Rhodopsin(INDUCES) 34262173 3 1 0 +MAP2K4 MKK4 EC 2.7.12.2; KINASE; Kinase, protein; Protein kinase, STE; Protein kinase, dual-specificity (non-receptor) P45985 6416 17p12 human Y269-p 1881548606 RDAGCRPyMAPERID enzymatic activity, inhibited carcinogenesis, inhibited; apoptosis, induced; transcription, inhibited 37020040 1 1 0 +EIF2AK2 PKR EC 2.7.10.2; EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, Other; Protein kinase, Ser/Thr (non-receptor); Protein kinase, tyrosine (non-receptor); Translation P19525 5610 2p22.2 human S97-p 1872824902 TNSSEGLsMGNYIGL molecular association, regulation; enzymatic activity, inhibited; protein conformation; phosphorylation apoptosis, inhibited PKR(INDUCES) RNA(INDUCES) 33911136 1 1 0 inhibits phosphorylation at other sites and of elF2 +Nanog NANOG Cell development/differentiation; DNA-binding; Transcription factor Q80Z64 71950 6|6 F1 mouse S130-p 1870790707 LQQMQELsSILNLSY Homeodomain molecular association, regulation; protein conformation DNA(DISRUPTS) 33107035 1 1 0 decreases self-renewal function of NANOG +Mpz myelin P0 Adaptor/scaffold; Membrane protein, integral P06907 24564 13q24 rat S233-p 458933 SRSTKAAsEKKSKGL Myelin-PO_C cell adhesion, altered 17502419 4 1 0 +Birc5 Survivin Apoptosis O70201 11799 11|11 E2 mouse T34-p 447705 FLEDCACtPERMAEA BIR protein stabilization; ubiquitination carcinogenesis, induced; apoptosis, inhibited; cell growth, altered 10949038; 18816410; 36450751 19 6 7 +AURKB AurB EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, Other; Protein kinase, Ser/Thr (non-receptor) Q96GD4 9212 17p13.1 human K85-sm 25087009 EIGRPLGkGKFGNVY Pkinase phosphorylation; enzymatic activity, induced 21554500 1 0 0 induces phosphorylation at T232 +PICK1 PICK1 Adaptor/scaffold; Cell development/differentiation; Ligand, receptor tyrosine kinase Q9NRD5 9463 22q13.1 human S411-p 50642304 GPLDKGGsWCDS___ molecular association, regulation GluR2(INDUCES) 26472923 1 2 0 S415 was essential for binding to GluA2 +EIF2AK2 PKR EC 2.7.10.2; EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, Other; Protein kinase, Ser/Thr (non-receptor); Protein kinase, tyrosine (non-receptor); Translation P19525 5610 2p22.2 human T88-p 3753308 AVSPLLLtTTNSSEG enzymatic activity, induced 11152499 1 0 0 +Map3k1 MEKK1 EC 2.7.11.25; KINASE; Kinase, protein; Ligase; Protein kinase, STE; Protein kinase, Ser/Thr (non-receptor); UBIQUITIN LIGASE; Ubiquitin conjugating system; Ubiquitin ligase P53349 26401 13 D2.2|13 63.36 cM mouse S71-p 3053616 RQLRKVRsVELDQLP enzymatic activity, induced 25260751 2 2 0 +PAPOLA PAP-alpha EC 2.7.7.19; RNA processing; RNA splicing; Transferase P51003 10914 14q32.2 human K662-sm 2586342 PHKEESPkKTKTEED protein stabilization; intracellular localization; enzymatic activity, inhibited 18281463 1 0 0 +Dppa4 DPPA4 Cell development/differentiation Q8CCG4 73693 16|16 B5 mouse K141-sm 1877126903 RLKTAHKkMKTEPGE transcription, inhibited 32937131 1 1 0 +Cdk7 CDK7 Cell cycle regulation; EC 2.7.11.22; EC 2.7.11.23; KINASE; Kinase, protein; Nuclear receptor co-regulator; Protein kinase, CMGC; Protein kinase, Ser/Thr (non-receptor) Q03147 12572 13 D1|13 53.23 cM mouse S164-p 450041 GLAKSFGsPNRAYTH Pkinase enzymatic activity, induced 7553872 4 52 21 +NOX5 NOX5 iso4 EC 1.6.3.-; Membrane protein, integral; Membrane protein, multi-pass; Oxidoreductase Q96PH1-4 79400 15q23 human S490-p 20612401 GRGSKRLsRSVTMRK FAD_binding_8 activity, induced; enzymatic activity, induced 24505490; 24992705 3 0 0 +CKAP2 CKAP2 Cell cycle regulation Q8WWK9 26586 13q14.3 human T623-p 460436 FKELKFLtPVRRSRR CKAP2_C protein degradation cell cycle regulation 19369249; 19641375 2 5 3 +GPSM2 GPSM2 G protein regulator, misc. P81274 29899 1p13.3 human S408-p 4766076 PKLGRRHsMENMELM molecular association, regulation; intracellular localization cell cycle regulation G-alpha i2(DISRUPTS) 20933426 2 21 9 stimulates binding to 14-3-3 +USP28 USP28 DEUBIQUITINASE; EC 3.4.19.12; Protease; Ubiquitin-specific protease Q96RU2 57646 11q23.2 human S714-p 467253 ESSTNSSsQDYSTSQ molecular association, regulation; ubiquitination; enzymatic activity, induced carcinogenesis, induced; DNA repair, induced; apoptosis, altered KLHL2(DISRUPTS) 16901786; 31938050; 34611298 4 4 0 induces substrate deubiquitination +ADD2 ADD2 Cytoskeletal; Motility/polarity/chemotaxis P35612 119 2p13.3 human S613-p 3147399 AKEAETKsPLVSPSK phosphorylation cell growth, induced; cytoskeletal reorganization 21606488 1 18 4 +Irf7 IRF7 DNA-binding; Transcription factor P70434 54123 7|7 F5 mouse K406-sm 3278901 EKTLILVkLEPWVCK IRF-3 transcription, inhibited 18635538 1 0 0 +Zc3h10 ZC3H10 DNA-binding Q8R205 103284 10|10 D3 mouse S126-p 36133857 VAAGLGLsPADLPNG molecular association, regulation transcription, induced DNA(INDUCES) 31775033 1 4 0 induces binding to UCP1 promoters +Scn8a SCN8A Channel, sodium; Membrane protein, integral; Membrane protein, multi-pass Q9WTU3 20273 15 56.39 cM|15 F1 mouse S553-p 456209 SLLSIPGsPFLSRHN Na_trans_cytopl molecular association, regulation; activity, inhibited NEDD4L(INDUCES) 20530479 2 0 1 +SSB SSB Transcription initiation complex P05455 6741 2q31.1 human T389-p 477729 VKRAREEtDKEEPAS carcinogenesis, induced; cell motility, induced; cell growth, induced; translation, induced 25520193; 33477794 2 5 153 Regulates cancer cell plasticity; CCND1 IRES-mediated translation (not Cap-dependent translation), inhibits RNA chaperon activity, regulates helix destabilization activity of La +NEDD1 NEDD1 Cell cycle regulation Q8NHV4 121441 12q23.1 human S568-p 25533011 AGVASSLsEKIADSI molecular association, regulation cytoskeletal reorganization TUBG1(INDUCES) 22595525 2 2 0 Promote NEDD1 activity; regulates spindle assembly in mitosis +RET Ret EC 2.7.10.1; KINASE; Kinase, protein; Membrane protein, integral; Oncoprotein; Protein kinase, TK; Protein kinase, tyrosine (receptor) P07949 5979 10q11.21 human Y900-p 450702 FGLSRDVyEEDSYVK PK_Tyr_Ser-Thr enzymatic activity, induced 14711813; 16928683; 28009299 2 4 23 +IL6ST gp130 Membrane protein, integral; Receptor, cytokine P40189 3572 5q11.2 human Y767-p 450053 STVVHSGyRHQVPSV cell cycle regulation; transcription, altered 10623831 2 1 5 +Grin2c NMDAR2C Channel, calcium; Channel, ligand-gated; Membrane protein, integral; Membrane protein, multi-pass Q00961 24411 10q32.1 rat S1231-p 463822 SCTWRRVsSLESEV_ activity, induced 16606616 1 1 0 regulates kinetics of ion channel +Tsc2 TSC2 iso2 Cell cycle regulation; GAP; GAP, misc.; Nuclear receptor co-regulator; Tumor suppressor P49816-2 24855 10q12 rat T1228-p 450211 PTLPRSNtVASFSSL phosphorylation 14651849 1 3 0 regulates p70S6K phosphorylation +SDC1 syndecan-1 Extracellular matrix; Membrane protein, integral; Motility/polarity/chemotaxis P18827 6382 2p24.1 human Y286-p 458494 KKKDEGSySLEEPKQ Syndecan endocytosis, induced 29109268 2 9 29 +MVP MVP RNA-binding Q14764 9961 16p11.2 human T52-p 28102700 FAPMRMVtVPPRHYC Vault_2 molecular association, regulation; activity, inhibited DNA repair, induced 14-3-3 epsilon(INDUCES) 23590642 1 0 0 14-3-3e negatively regulating the BLM resistance activity of MVP and induce DDR +Gabrg2 GABRG2 iso2 Channel, chloride; Channel, ligand-gated; Membrane protein, integral; Membrane protein, multi-pass; Transporter; Transporter, ion channel P22723-2 14406 11 A5|11 24.8 cM mouse Y405-p 455818 ERDEEYGyECLDGKD Neur_chan_memb receptor inactivation, induced; activity, induced; receptor internalization, inhibited neural plasticity 17442679; 23904608; 24068823 7 0 0 potentiated GABA currents; neurogenesis, reduces depressive like behaviors; knockout leads to increease in GABA mediated tonic current, in females only +VAV3 VAV3 Actin-binding; Adaptor/scaffold; GEF; GEF, Rac/Rho; Motility/polarity/chemotaxis; Nuclear receptor co-regulator Q9UKW4 10451 1p13.3 human Y173-p 455605 EDEGGEVyEDLMKAE activity, induced 11917103; 32561640 6 0 0 VAV3 signaling activity +H4C1 H4 DNA-binding P62805 8359 6p22.2 human R3-me 4145501 _____SGrGKGGKGL acetylation cell cycle regulation; chromatin organization, altered; transcription, induced; transcription, inhibited 11387442; 15345777; 19741270 6 0 0 regulates epigenetic regulation of chromation in a cell-cycle dependent manner +CYLD CYLD DEUBIQUITINASE; EC 3.4.19.12; Protease; Tumor suppressor; Ubiquitin conjugating system; Ubiquitin-specific protease Q9NQC7 1540 16q12.1 human S422-p 4745563 RFHSLPFsLTKMPNT CYLD_phos_site ubiquitination 15870263 1 14 4 induces ubiquitination of TRAF2 +XRCC6 Ku70 DNA repair, damage; DNA-binding; EC 3.6.4.-; EC 4.2.99.-; Helicase; Nuclear receptor co-regulator; RNA-binding P12956 2547 22q13.2 human S33-p 50247606 ASGDYKYsGRDSLIF molecular association, regulation; intracellular localization cell cycle regulation; DNA repair, induced; chromatin organization, altered; DNA repair, altered; apoptosis, inhibited UBE2M(DISRUPTS); UBE2A(INDUCES); RIF1(INDUCES); N4BP1(INDUCES); POLR2F(INDUCES); UBE2G2(INDUCES); TIF1G(INDUCES) DNA(DISRUPTS) 26337656; 34718776 2 1 0 +PELI1 PELI1 Adaptor/scaffold; EC 6.3.2.-; EC 6.3.2.19; Ligase; UBIQUITIN LIGASE; Ubiquitin conjugating system; Ubiquitin ligase Q96FA3 57162 2p14 human S39-p 1870773105 GDRGRRKsRFALFKR Pellino protein degradation; molecular association, regulation; ubiquitination RIPK1(DISRUPTS); TICAM1(DISRUPTS); ubiquitin(DISRUPTS) 33052227 1 0 0 +SEC16A SEC16A EC 3.1.3.36; Phosphatase (non-protein) O15027 9919 9q34.3 human S846-p 55578720 LAQPINFsVSLSNSH intracellular localization autophagy, induced 27203176 1 1 0 assembly of COPII components at ERESs and traf?cking of associated secretory cargos +CDKN1B p27Kip1 Cell cycle regulation; Inhibitor; Oncoprotein; Protein kinase, regulatory subunit P46527 1027 12p13.1 human S10-p 447874 NVRVSNGsPSLERMD protein degradation; molecular association, regulation; protein stabilization; intracellular localization; phosphorylation cell cycle regulation; carcinogenesis, induced; cell motility, induced; cell adhesion, induced; transcription, altered; cell growth, induced; apoptosis, inhibited; cytoskeletal reorganization CTNNB1(DISRUPTS); Exportin-1(INDUCES) 10831586; 11726503; 11889117; 12093740; 12119282; 12482975; 12529437; 12700233; 15579463; 16160006; 18272788; 19672859; 20851109; 21715331; 23230143; 25205104; 26223520; 26307683; 26528715; 27175940; 27197201; 33316141 47 36 1 migration and invasion, cytoplasmic localization; S-phase entry in E7 expressing cells +Pttg1 Securin Cell cycle regulation; Oncoprotein Q9CQJ7 30939 11|11 B1.1 mouse S162-p 452603 LLHLGPPsPLKTPFL Securin activity, induced; intracellular localization transcription, altered 10906323 2 50 2 +Prkar2b PKAR2B Mitochondrial; Protein kinase, regulatory subunit P12369 24679 6q16 rat T69-p 10941783 GAAAGGGtPSKGVNF protein conformation; phosphorylation neural plasticity 35835216 1 12 1 +Ctnnb1 CTNNB1 Actin-binding; Cell adhesion; Motility/polarity/chemotaxis; Nuclear receptor co-regulator; Oncoprotein; Transcription factor Q02248 12387 9 F4|9 72.19 cM mouse S29-p 3075000 VSHWQQQsYLDSGIH protein degradation; ubiquitination 9233789 3 2 4 +AFAP1 AFAP Adaptor/scaffold Q8N556 60312 4p16.1 human S277-p 2853100 AELEKKLsSERPSSD cytoskeletal reorganization 18577577 1 13 1 +Trp53 p53 iso2 Activator; DNA-binding; Motility/polarity/chemotaxis; Nuclear receptor co-regulator; Transcription factor; Tumor suppressor Q80ZA1 22059 11 B3|11 42.83 cM mouse K117-ac 474514 FLQSGTAkSVMCTYS P53 transcription, induced 27705786 44 8 0 +HSF1 HSF1 DNA-binding; Transcription factor Q00613 3297 8q24.3 human K80-ac 6741100 LNMYGFRkVVHIEQG HSF_DNA-bind protein degradation; molecular association, regulation; ubiquitination; intracellular localization apoptosis, induced; transcription, inhibited DNA(DISRUPTS) 19229036; 26503960; 28547133 5 2 0 +Glrb GLRB Channel, ligand-gated; Membrane protein, integral; Membrane protein, multi-pass; Transporter; Transporter, ion channel P48168 14658 3 E3|3 35.71 cM mouse S425-p 2048205 NDFSIVGsLPRDFEL Neur_chan_memb receptor internalization, induced; molecular association, regulation; intracellular localization neural plasticity; endocytosis, induced PACSIN1(INDUCES); gephyrin(DISRUPTS) 21829170; 35879097 2 3 0 +PPP1R16B PPP1R16B Motility/polarity/chemotaxis; Protein phosphatase, regulatory subunit Q96T49 26051 20q11.23 human S331-p 62459400 SQLRHKSsLSRRTSS molecular association, regulation; intracellular localization; activity, inhibited ERM(DISRUPTS) 27939168 1 0 0 membrane localization +MECOM EVI1 C2H2-type zinc finger protein; Methyltransferase, protein lysine, predicted; Oncoprotein; Transcription regulation; Transcription, coactivator/corepressor Q03112 2122 3q26.2 human S384-p 28704101 ICEVCHKsYTQFSNL zf-C2H2 molecular association, regulation transcription, inhibited DNA(DISRUPTS) 23776681 1 1 0 +EEA1 EEA1 C2H2-type zinc finger protein; Vesicle Q15075 8411 12q22 human T1392-p 456871 CSAKNALtPSSKKPV FYVE activity, induced; intracellular localization 16138080 1 0 0 Phosphorylation required for efficient binding to endosome membranes. Aspartate mutation can restore EEA1 fusion activity in the absence of p38a. +MYH10 MYH10 Motility/polarity/chemotaxis; Motor P35580 4628 17p13.1 human S1938-p 4730824 GGPISFSsSRSGRRQ cytoskeletal reorganization 25869664 1 10 3 poorly defined actomyosin bundles distributed throughout the cell +PDE4D PDE4D iso6 EC 3.1.4.53; Nucleotide Metabolism - purine; Phosphodiesterase Q08499-6 5144 5q11.2-q12.1 human S651-p 451090 YQSTIPQsPSPAPDD enzymatic activity, altered 31209056 7 3 0 +H2AX H2AX DNA repair, damage; DNA-binding; Helicase P16104 3014 11q23.3 human Y39-p 462307 RLLRKGHyAERVGAG Histone carcinogenesis, induced; carcinogenesis, inhibited; autophagy, induced; cell growth, induced; transcription, induced; transcription, altered 27813335; 30185813; 31736361 3 2 2 +VDR VDR DNA-binding; Nuclear receptor; Transcription factor P11473 7421 12q13.11 human S51-p 451285 CKGFFRRsMKRKALF zf-C4 transcription, induced 1656468 2 0 0 Mutation of S51 inhibited transcriptional activation by the vitamin D hormone, suggesting that phosphorylation of S51 could play a role in vitamin D dependent transcriptional activation. +CYLD CYLD DEUBIQUITINASE; EC 3.4.19.12; Protease; Tumor suppressor; Ubiquitin conjugating system; Ubiquitin-specific protease Q9NQC7 1540 16q12.1 human Y15-p 4157933 QEKVTSPyWEERIFY protein degradation; molecular association, regulation; ubiquitination Cbl-b(INDUCES) 28572092 1 3 3 degradation of EGFR +SGK1 SGK1 EC 2.7.11.1; KINASE; Kinase, protein; Motility/polarity/chemotaxis; Protein kinase, AGC; Protein kinase, Ser/Thr (non-receptor) O00141 6446 6q23.2 human T369-p 448432 DLINKKItPPFNPNV enzymatic activity, induced 11096081 2 0 0 +TGFBR1 TGFBR1 EC 2.7.11.30; KINASE; Kinase, protein; Membrane protein, integral; Protein kinase, Ser/Thr (receptor); Protein kinase, TKL; Receptor, misc. P36897 7046 9q22.33 human Y182-p 7791190 TTLKDLIyDMTTSGS TGF_beta_GS molecular association, regulation Src(INDUCES) 36378749 2 1 2 src autophosphorylation induced +Map3k7 TAK1 EC 2.7.11.25; KINASE; Kinase, protein; Protein kinase, Ser/Thr (non-receptor); Protein kinase, TKL P0C8E4 313121 5q21 rat T184-p 454876 GTACDIQtHMTNNKG PK_Tyr_Ser-Thr enzymatic activity, induced cell cycle regulation; autophagy, induced; cell motility, induced; cell growth, induced 35078016 20 0 0 +NCOA2 SRC-2 Motility/polarity/chemotaxis; Nuclear receptor co-regulator; Transcription, coactivator/corepressor Q15596 10499 8q13.3 human S493-p 468245 LSPRHRMsPGVAGSP NCOA_u2 transcription, induced 22158970 2 38 0 +TLR8 TLR8 Membrane protein, integral; Receptor, misc. Q9NR97 51311 Xp22.2 human Y880-p 953801 LSTSQTFyDAYISYD TIR activity, induced signaling pathway regulation 17868034 1 0 0 activates NF-kB activity +Ssh2 SSH2 Actin-binding; EC 3.1.3.16; EC 3.1.3.48; PHOSPHATASE; Protein phosphatase, dual-specificity Q5SW75 237860 11|11 B5 mouse S32-p 22775200 SGEEECRsQPRSISE enzymatic activity, inhibited cytoskeletal reorganization; cell motility, inhibited 22172670 1 0 0 +Cd28 CD28 Cell surface; Membrane protein, integral P31041 12487 1 C2|1 30.52 cM mouse Y189-p 450282 NRLLQSDyMNMTPRR molecular association, regulation; phosphorylation cell growth, induced; transcription, induced PIK3CB(INDUCES); PIK3CD(INDUCES); PIK3R1(INDUCES); PIK3CA(INDUCES) 21188463; 24048955; 9973466 10 7 317 induces phosphorylation of ERK and AKT and transcription of IL-2 +PARP1 PARP1 DNA repair, damage; EC 2.4.2.30; Nuclear envelope; Nuclear receptor co-regulator; Nucleolus; Transferase P09874 142 1q42.12 human S782-p 3180399 YSLLRGGsDDSSKDP PARP_reg intracellular localization; enzymatic activity, inhibited; enzymatic activity, induced 21922195; 25069723 2 34 1 Non-apoptotic cell death induced +IQCB1 IQCB1 Cell development/differentiation Q15051 9657 3q13.33|3q21.1 human K31-ub 95155301 NVPVILLkLKEIINI intracellular localization cell cycle regulation; cytoskeletal reorganization 28498859 1 2 0 regulation of cilia formation +Mybpc3 MYBPC3 Myosin-binding P56741 295929 3q24 rat S307-p 471081 SSLLKKSsFRRDSKL cytoskeletal reorganization 35288601 28 6 0 +Pdlim2 PDLIM2 Cell adhesion; UBIQUITIN LIGASE; Ubiquitin ligase Q8R1G6 213019 14|14 D2 mouse S137-p 4763817 PRPCSPFsTPPPTSP ubiquitination; enzymatic activity, induced 20889505 1 14 28 PDLIM2 is STAT1 ubiquitin E3 ligase +UBA2 SAE2 EC 6.3.2.-; EC 6.3.2.19; Ligase; Motility/polarity/chemotaxis; SUMO LIGASE; SUMO conjugating system; SUMO ligase; UBIQUITIN LIGASE; Ubiquitin conjugating system; Ubiquitin ligase Q9UBT2 10054 19q13.11 human K623-sm 10304919 EKENLSAkRSRIEQK UBA2_C intracellular localization 23095757 2 2 0 nuclear localization +Ddit3 DDIT3 Autophagy; DNA-binding; Oncoprotein; Transcription factor P35639 13198 10|10 D3 mouse S107-p 40509923 RTRKRKQsGQCPARP bZIP_2 intracellular localization 32673756 1 2 0 +DNMT1 DNMT1 Amino Acid Metabolism - cysteine and methionine; Cell development/differentiation; EC 2.1.1.37; METHYLTRANSFERASE; Methyltransferase; Methyltransferase, DNA; Transcription regulation P26358 1786 19p13.2 human K259-ac 25171012 PTPKQKLkEEPDREA cell cycle regulation 21947282 1 1 0 +HMGA1 HMGA1 iso2 DNA-binding P17096-2 3159 6p21.31 human K54-ac 458952 RGRPKGSkNKGAAKT AT_hook apoptosis, induced 11389094 4 3 0 +Cebpa C/EBP-alpha DNA-binding; Transcription factor P05554 24252 1q21 rat K302-ac 56394105 AVRKSRDkAKQRNVE bZIP_2 molecular association, regulation autophagy, induced beclin 1(INDUCES) 34217716 2 0 0 +DNMT1 DNMT1 Amino Acid Metabolism - cysteine and methionine; Cell development/differentiation; EC 2.1.1.37; METHYLTRANSFERASE; Methyltransferase; Methyltransferase, DNA; Transcription regulation P26358 1786 19p13.2 human K1609-sm 12726305 ESASAKIkEEEAAKD enzymatic activity, induced DNA(INDUCES) 19450230 1 1 0 +CAPZB CAPZB iso1 Actin-binding; Motility/polarity/chemotaxis P47756-1 832 1p36.13 human S192-p 23090287 GTMNLGGsLTRQMEK F_actin_cap_B cell motility, induced; cell adhesion, induced; cytoskeletal reorganization 32771000 1 1 1 +Rfc1 RFC1 DNA replication D3ZFT1 89809 14p11 rat S361-p 3136107 GSPTKREsVSPEDSE transcription, induced 10625661 1 11 0 +CAPN2 CAPN2 EC 3.4.22.53; Motility/polarity/chemotaxis; Protease P17655 824 1q41 human Y625-p 3413522 RSGTMNSyEMRKALE enzymatic activity, induced carcinogenesis, induced; cell growth, inhibited 35697802 1 0 1 +Ptk2 FAK EC 2.7.10.2; KINASE; Kinase, protein; Protein kinase, TK; Protein kinase, tyrosine (non-receptor) P34152 14083 15 D3|15 33.94 cM mouse Y925-p 447966 DRSNDKVyENVTGLV Focal_AT molecular association, regulation; phosphorylation cell motility, induced; cell adhesion, induced; cytoskeletal reorganization; transcription, altered; cell growth, altered GRB2(INDUCES) 16682956; 16818654; 33711252; 35325397; 7997267; 8816475; 9148935; 9566877 104 17 427 induces cofilin phosphorylation +Myocd myocardin Cell development/differentiation; Transcription factor Q8VIM5 214384 11|11 B3 mouse S632-p 3627509 TFLSPQCsPQHSPLG transcription, inhibited 16141410 1 0 0 +ADAR ADAR EC 3.5.4.37; Hydrolase; Nucleolus; RNA processing; RNA-binding P55265 103 1q21.3 human K574-ub 59149208 TILLEEAkAKDSGKS protein degradation 27729454 1 1 0 regulation of IFN-signaling induced anti-viral activity +ILF3 NFAT90 DNA-binding; Nucleolus; RNA-binding; Transcription factor Q12906 3609 19p13.2 human S382-p 456735 EEDGEEKsPSKKKKK intracellular localization cell cycle regulation; carcinogenesis, induced; cell growth, induced; RNA stability, induced 32123579 1 55 13 +COIL coilin Oxidoreductase P38432 8161 17q22 human S489-p 483597 LELTSSYsPDVSDYK protein degradation; molecular association, regulation; enzymatic activity, inhibited; intracellular localization; activity, inhibited cell cycle regulation; cell growth, inhibited; RNA stability, induced RNA(INDUCES) 21991343; 23616925 2 16 0 nucleolar accumulation; not observed during transient expression; Cajal body formation, phosphomutant cell lines show a significant reduction in CB formation compared to wild-type after endogenous coilin knockdown; inhibits coilin RNAse activity +LIME1 LIME1 Adaptor/scaffold; Membrane protein, integral Q9H400 54923 20q13.33 human Y200-p 454607 AAQVDVLySRVCKPK LIME1 molecular association, regulation CSK(INDUCES) 14610046 1 8 85 +SYTL1 SYTL1 Q8IYJ3 84958 1p36.11 human S241-p 456480 RMLSSSSsVSSLNSS intracellular localization RAB27A(NOT_REPORTED) 15998322 1 0 0 +CHCHD2 CHCHD2 Mitochondrial Q9Y6H1 51142 7p11.2 human Y99-p 62463400 PARPDITyQEPQGTQ transcription, inhibited 33257573 3 1 0 induces mitochondrial respiration +RXRA RXRA DNA-binding; Motility/polarity/chemotaxis; Nuclear receptor P19793 6256 9q34.2 human K108-sm 12004418 VSSSEDIkPPLGLNG Nuc_recep-AF1 transcription, inhibited 16912044; 23690070 2 1 0 +KCNMA1 KCNMA1 Channel, potassium; Endoplasmic reticulum; Membrane protein, integral; Membrane protein, multi-pass Q28204 282573 cow S1151-p 14364501 NRQNRPKsRESRDKQ activity, inhibited 20385812 1 0 0 +RUBCNL RUBCNL Q9H714 80183 13q14.13 human K483-ac 1875445903 LMMWDFKkYYVSNFS zf-RING_9 molecular association, regulation autophagy, induced VPS39(INDUCES); VPS41(INDUCES); STX17(INDUCES) 30704899 1 1 0 required for autophagosome maturation and cellular lipid metabolism +Dab1 DAB1 Adaptor/scaffold Q8CJH2 266729 5q33-q34 rat S400-p 479417 TNDSARSsPQSDKPR molecular association, regulation CD2AP(DISRUPTS); SH3KBP1(DISRUPTS) 18076569 3 0 0 +XKR5 XKR5 Membrane protein, integral; Membrane protein, multi-pass Q6UX68 389610 8p23.1 human Y487-p 1172732402 DPLETSSyVSFASDQ phosphorylation carcinogenesis, inhibited; cell growth, inhibited; signaling pathway regulation 29910466 1 1 0 inhibits phosphorylation of ERK, AKT and p38 +BCL2L11 BIM Apoptosis O43521 10018 2q13 human S93-p 8080215 SSLLSRSsSGYFSFD protein degradation; molecular association, regulation; ubiquitination BTRC(INDUCES) 23912711 1 0 0 +SPRY2 SPRY2 Adaptor/scaffold; Inhibitor; Motility/polarity/chemotaxis O43597 10253 13q31.1 human T75-p 4145505 KPAPRPStQHKHERL activity, inhibited 18678649 2 0 0 +Tom1l1 Srcasm Adaptor/scaffold Q923U0 71943 11 D|11 55.47 cM mouse Y392-p 451208 NLASSHTyDNFHSNS molecular association, regulation cell growth, altered GRB2(INDUCES) 11711534; 17046829 3 0 1 mutation of this site promotes hyperproliferative phenotype +TAX1BP1 TAX1BP1 iso2 Apoptosis Q86VP1-2 8887 7p15.2 human S624-p 468908 RPPVRVPsWGLEDNV molecular association, regulation; ubiquitination signaling pathway regulation TRAF2(INDUCES); TRAF6(INDUCES) 21765415 1 21 106 regulates NF-kB signaling; ; regulates interaction with A20 and Itch via TRAF2 and TRAF6 +Aicda AID EC 3.5.4.38; Hydrolase Q9WVE0 11628 6|6 F1 mouse T140-p 6835300 GVQIGIMtFKDYFYC APOBEC2 molecular association, regulation; intracellular localization DNA repair, inhibited RPA1(INDUCES) 21113164 3 0 0 interaction of RPA with Igh +UBA2 SAE2 EC 6.3.2.-; EC 6.3.2.19; Ligase; Motility/polarity/chemotaxis; SUMO LIGASE; SUMO conjugating system; SUMO ligase; UBIQUITIN LIGASE; Ubiquitin conjugating system; Ubiquitin ligase Q9UBT2 10054 19q13.11 human K613-sm 27851104 EERSRKRkLDEKENL UBA2_C intracellular localization 23095757 1 1 0 nuclear localization +FBXW7 FBXW7 Motility/polarity/chemotaxis; Nucleolus; UBIQUITIN LIGASE; Ubiquitin conjugating system; Ubiquitin ligase Q969H0 55294 4q31.3 human T205-p 25585000 GLVPCSAtPTTFGDL protein degradation; molecular association, regulation; ubiquitination carcinogenesis, induced; cell growth, induced; apoptosis, inhibited; transcription, induced PIN1(INDUCES) 22608923; 25753158; 31152129; 33271455 5 1 0 +PPP1CC PPP1CC EC 3.1.3.16; Motility/polarity/chemotaxis; Nucleolus; PHOSPHATASE; Protein phosphatase, Ser/Thr (non-receptor) P36873 5501 12q24.11 human T318-p 11379600 TPPRGMItKQAKK__ enzymatic activity, inhibited 10880350 1 1 0 in vitro +TAB1 TAB1 Activator; Motility/polarity/chemotaxis Q15750 10454 22q13.1 human S438-p 456224 TPTLTNQsPTLTLQS molecular association, regulation; enzymatic activity, induced; phosphorylation carcinogenesis, induced; autophagy, induced; signaling pathway regulation GFAT(INDUCES) 19393267; 24403530; 35945223 8 1 0 TCR-signaling by DUSP14; induces p38 activity; inhibits TAK1 T187 phosphorylation +NFE2L2 NRF2 DNA-binding; Transcription factor Q16236 4780 2q31.2 human K596-ac 23940022 GNVFLVPkSKKPDVK molecular association, regulation; intracellular localization transcription, induced DNA(INDUCES) 21196497 1 0 0 +RHOT1 RHOT1 EC 3.6.5.-; G protein; G protein, monomeric; G protein, monomeric, Rho; Hydrolase; Membrane protein, integral; Mitochondrial Q8IXI2 55288 17q11.2 human S156-p 21587701 AKNLKNIsELFYYAQ Ras protein degradation autophagy, induced 22078885; 35455950 4 1 0 induces mitophagy; arrest of mitochondrial motility +Zfp24 ZNF24 C2H2-type zinc finger protein; DNA-binding; Transcription factor Q91VN1 59057 18|18 A2 mouse T330-p 480061 INHQRIHtGEKPYEC molecular association, regulation cell differentiation, inhibited; transcription, inhibited DNA(DISRUPTS) 29786073; 29791837 2 7 49 regulates oligodendrocyte differentiation and CNS myelination; mediates the expression of Sox10 and Myrf; oligodendrocyte differentiation and myelination +GSTA4 GSTA4 EC 2.5.1.18; Other Amino Acids Metabolism - glutathione; Transferase; Xenobiotic Metabolism - drug metabolism - cytochrome P450; Xenobiotic Metabolism - metabolism by cytochrome P450 O15217 2941 6p12.2 human T193-p 455667 VKLSNIPtIKRFLEP GST_C_3 molecular association, regulation; intracellular localization HSP70(INDUCES) 12646569 1 0 0 +PML PML Nucleolus; Oncoprotein; SUMO LIGASE; SUMO conjugating system; SUMO ligase; Transcription factor; Tumor suppressor; Ubiquitin conjugating system P29590 5371 15q24.1 human T409-p 469197 ASPEAAStPRDPIDV DUF3583 carcinogenesis, altered 20832753 1 9 28 +AR AR DNA-binding; Nuclear receptor; Transcription factor P10275 367 Xq12 human Y535-p 470068 MDSYSGPyGDMRLET intracellular localization cell cycle regulation; cell growth, induced; transcription, induced; transcription, altered 17045208; 28055971 4 1 0 +RPS6KA5 MSK1 EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, AGC; Protein kinase, Ser/Thr (non-receptor) O75582 9252 14q32.11 human T581-p 448217 PDNQPLKtPCFTLHY Pkinase intracellular localization; enzymatic activity, induced cell growth, induced; transcription, induced; cytoskeletal reorganization 15568999; 15728587; 17429437; 19940164; 25958199 16 1 0 transcriptional activation of Fra-1 and c-Jun +Gucy1a1 GUCY1A1 EC 4.6.1.2; Guanylyl cyclase; Lyase; Nucleotide Metabolism - purine; Receptor, misc. P19686 497757 2q34 rat S108-p 450955 IKENRNSsEKEDLER enzymatic activity, induced 14630997 1 0 0 +Cftr CFTR Channel, chloride; EC 3.6.3.49; Hydrolase; Membrane protein, integral; Membrane protein, multi-pass; Transporter; Transporter, ABC family P26361 12638 6 A2|6 8.1 cM mouse S660-p 449979 FTEERRSsILTETLR CFTR_R protein conformation 19927121 9 8 0 in vitro +INSR INSR EC 2.7.10.1; KINASE; Kinase, protein; Membrane protein, integral; Protein kinase, TK; Protein kinase, tyrosine (receptor) P06213 3643 19p13.2 human Y1361-p 447684 SYEEHIPyTHMNGGK protein conformation; enzymatic activity, induced cell cycle regulation; cell growth, altered 10852715; 10940390; 1618780; 1654097 15 7 14 antibodies against Y1355 and Y1361 peptides stimulated cell proliferation. ; decreases ERK activation +IFITM2 IFITM2 Membrane protein, integral; Membrane protein, multi-pass Q01629 10581 11p15.5 human Y19-p 15230944 NSGQPPNyEMLKEEQ intracellular localization 26354436 1 2 3 Wild-type was localized in cytoplasm and perinuclear, while Y19A,Y20A was localized at plasma membrane. +Ndel1 NDEL1 Microtubule-binding; Protease Q9ERR1 83431 11|11 B3 mouse T219-p 468252 ASLSLPAtPVGKGTE NUDE_C activity, induced; intracellular localization cell motility, altered; cytoskeletal reorganization 18331715; 25698733 6 15 3 impaired transport of DISC1and PAFAH1B1 to neurite tips, inhibited microtuble elongation; Cdc42 activation +CBL CBL Adaptor/scaffold; EC 6.3.2.-; EC 6.3.2.19; Ligase; Motility/polarity/chemotaxis; Oncoprotein; UBIQUITIN LIGASE; Ubiquitin conjugating system; Ubiquitin ligase P22681 867 11q23.3 human S642-p 4704608 PRLGSTFsLDTSMSM molecular association, regulation 14-3-3 eta(INDUCES) 11024037 1 4 7 +GAK GAK Cell cycle regulation; EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, Other; Protein kinase, Ser/Thr (non-receptor) O14976 2580 4p16.3 human Y1149-p 23108884 CTQPRPNyASNFSVI intracellular localization; phosphorylation cell cycle regulation; cell growth, induced 28135906 1 0 3 regulation of MCM2 and timing of MCM3 S112 phosphorylation +ERBB2 HER2 EC 2.7.10.1; KINASE; Kinase, protein; Membrane protein, integral; Oncoprotein; Protein kinase, TK; Protein kinase, tyrosine (receptor) P04626 2064 17q12 human Y1248-p 447614 PTAENPEyLGLDVPV activity, induced; protein stabilization; molecular association, regulation; intracellular localization; phosphorylation cell cycle regulation; carcinogenesis, induced; cell motility, induced; transcription, induced; signaling pathway regulation; cell growth, induced; cell motility, altered; apoptosis, inhibited; cytoskeletal reorganization CPNE3(INDUCES); RACK1(INDUCES); SHC1(INDUCES) 11238891; 12354693; 12748185; 16729043; 18332126; 20010870; 21499301; 27345410; 31978707; 32029900; 37331014 60 15 200 +ESRRA ERR1 DNA-binding; Nuclear receptor; Transcription regulation P11474 2101 11q13.1 human K129-ac 15211513 EITKRRRkACQACRF zf-C4 molecular association, regulation transcription, inhibited DNA(DISRUPTS) 20484414 1 0 0 +SNAI2 Snail2 Apoptosis; C2H2-type zinc finger protein; Motility/polarity/chemotaxis; Transcription factor O43623 6591 8q11.21 human K211-ac 1876931101 IRTHTGEkPFSCPHC protein stabilization cell motility, induced 32737855 1 1 0 promotes breast cancer cell EMT and migration +CPSF3 CPSF3 EC 3.1.27.-; RNA processing; RNA splicing; RNA-binding; Ribonuclease Q9UKF6 51692 2p25.1 human K465-sm 2586338 FRGEKLAkVMGFLAD RNA splicing, altered; cell growth, induced 17923699 1 0 0 regulation of mRNA 3'-end processing- cleavage and polyadenylation +MEF2C MEF2C DNA-binding; Transcription factor Q06413 4208 5q14.3 human K391-sm 7533202 STQSLNIkSEPVSPP transcription, inhibited 16478538 1 0 0 +Ulk1 ULK1 Autophagy; EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, Other; Protein kinase, Ser/Thr (non-receptor) O70405 22241 5|5 F mouse T574-p 17741300 PKLPKPPtDPLGATF autophagy, altered 21205641 0 4 6 +SRC Src EC 2.7.10.2; KINASE; Kinase, protein; Oncoprotein; Protein kinase, TK; Protein kinase, tyrosine (non-receptor) P12931 6714 20q11.23 human S493-p 1871762502 CPPECPEsLHDLMCQ PK_Tyr_Ser-Thr enzymatic activity, inhibited; phosphorylation 33388549 1 0 0 inhibits phosphorylation at Y419 +UHRF1 UHRF1 DNA-binding; EC 6.3.2.-; EC 6.3.2.19; Ligase; Transcription factor; UBIQUITIN LIGASE; Ubiquitin conjugating system; Ubiquitin ligase Q96T88 29128 19p13.3 human S661-p 469962 GGPSRAGsPRRTSKK intracellular localization 22072796 3 12 0 essential for pre-gastrula development in zebrafish +Vcl Vinculin Cell adhesion; Cytoskeletal; Motility/polarity/chemotaxis Q64727 22330 14 A3|14 11.53 cM mouse Y100-p 454004 QMLQSDPySVPARDY Vinculin activity, induced; molecular association, regulation; protein conformation cell motility, induced; cell growth, induced; cell adhesion, induced; cytoskeletal reorganization 26240176; 36207442 4 3 53 +H4c2 H4 DNA-binding P62806 326620 13|13 A3.1 mouse K20-m3 2344825 GGAKRHRkVLRDNIQ CENP-T_C carcinogenesis, induced; chromatin organization, altered; transcription, inhibited; transcription, altered 18728284; 19434510; 20543957; 26304540 35 14 0 +Rps5 RPS5 RNA-binding; Ribosomal; Translation P97461 20103 7|7 A1 mouse T133-p 9819905 TRIGRAGtVRRQAVD Ribosomal_S7 intracellular localization; phosphorylation 19631221 1 1 0 triggers phosphorylation of S23 +HSPB1 HSP27 Chaperone; Heat shock protein; Motility/polarity/chemotaxis; SUMO LIGASE; SUMO ligase Q00649 chicken S81-p 452224 RALSELSsGISEIRQ protein conformation 12429504 3 21 23 Mutations mimicking phosphorylation of sites single (S15D) and in combination form high and low molecular oligomers and affect chaperone activity in vitro. +HDAC4 HDAC4 DEACETYLASE; Deacetylase; EC 3.5.1.98; Hydrolase; Nuclear receptor co-regulator; SUMO LIGASE P56524 9759 2q37.3 human S584-p 41452201 EPGQRQPsEQELLFR activity, induced transcription, inhibited 30661366 1 4 0 transcription of MEF2 target genes RhoB and Klf2 +MCM4 MCM4 DNA replication; EC 3.6.4.12 P33991 4173 8q11.21 human T19-p 448634 GSRRGRAtPAQTPRS activity, inhibited 12714602 3 21 16 +C5AR1 C5aR GPCR, family 1; Membrane protein, integral; Membrane protein, multi-pass; Receptor, GPCR P21730 728 19q13.32 human S317-p 450056 RLRKSLPsLLRNVLT molecular association, regulation ARRB1(INDUCES); ARRB2(INDUCES) 12464600 2 3 0 +IGF1R IGF1R EC 2.7.10.1; KINASE; Kinase, protein; Membrane protein, integral; Protein kinase, TK; Protein kinase, tyrosine (receptor) P08069 3480 15q26.3 human Y1166-p 448388 DIYETDYyRKGGKGL PK_Tyr_Ser-Thr protein conformation; enzymatic activity, induced; phosphorylation autophagy, induced; apoptosis, inhibited; cell growth, altered 11591350; 15334055; 16793764; 34921013; 7798258 16 15 107 +MAP3K14 Nik EC 2.7.11.25; KINASE; Kinase, protein; Protein kinase, STE; Protein kinase, Ser/Thr (non-receptor) Q99558 9020 17q21.31 human T559-p 455390 TGDYIPGtETHMAPE Pkinase enzymatic activity, induced transcription, altered 9742107 3 0 0 +ATG4B ATG4B Autophagy; EC 3.4.22.-; Protease; Ubiquitin conjugating system Q9Y4P1 23192 2q37.3 human S34-p 4750282 WILGRKYsIFTEKDE protein degradation; intracellular localization; enzymatic activity, induced autophagy, induced ATP5C(INDUCES) 29165041; 33607258 2 4 0 increased localization and import to mitochondria; inhibits the F1Fo-ATP synthase activity; promotes p62 degradation; promotes Warburg effect +INSR INSR iso2 EC 2.7.10.1; KINASE; Kinase, protein; Membrane protein, integral; Protein kinase, TK; Protein kinase, tyrosine (receptor) P06213-2 3643 19p13.2 human Y987-p 447685 YASSNPEyLSASDVF activity, induced 1656240 25 0 0 mutation of site impairs insulin stimulation of PI3K activity. +STK38L NDR2 EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, AGC; Protein kinase, Ser/Thr (non-receptor) Q9Y2H1 23012 12p11.23 human T75-p 460299 SQHARKEtEFLRLKR molecular association, regulation; enzymatic activity, induced cell growth, altered S100B(INDUCES) 15037617; 16488889 2 0 0 +FZR1 FZR1 UBIQUITIN LIGASE; Ubiquitin conjugating system Q9UM11 51343 19p13.3 human S42-gl 55596600 SSPVSSPsKHGDRFI activity, induced; molecular association, regulation CDC27(INDUCES) 27080259 1 1 0 promotes the interaction between FZR1 and APC/C subunits, enhances APC/C activity +LAMTOR5 HBXIP Apoptosis; DNA replication O43504 10542 1p13.3 human S26-p 482652 VGVLCTDsQGLNLGC LAMTOR5 molecular association, regulation; intracellular localization; phosphorylation carcinogenesis, induced; transcription, induced Fos(INDUCES) 23667255 1 3 3 phosphorylation of c-Fos +SLBP SLBP RNA-binding Q14493 7884 4p16.3 human S23-p 470508 DGDASPPsPARWSLG protein degradation; ubiquitination 22907757 1 35 28 +Insr INSR EC 2.7.10.1; KINASE; Kinase, protein; Membrane protein, integral; Protein kinase, TK; Protein kinase, tyrosine (receptor) P15208 16337 8 A1.1|8 1.82 cM mouse Y1001-p 449048 DVFPSSVyVPDEWEV signaling pathway regulation 20332342 5 0 2 Rictor/mTORC2 signaling in energy metabolism in fat cells +NFE2L2 NRF2 DNA-binding; Transcription factor Q16236 4780 2q31.2 human T439-p 40642202 VSPGHRKtPFTKDKH intracellular localization 25909891 1 0 0 nuclear translocation +MISP MISP Unknown function Q8IVT2 126353 19p13.3 human S395-p 3205359 GLRRALSsDSILSPA AKAP2_C cytoskeletal reorganization 34023777 1 19 31 +WWTR1 TAZ Oncoprotein; Transcription, coactivator/corepressor Q9GZV5 25937 3q25.1 human Y321-p 27138200 SGLGLGCySVPTTPE intracellular localization carcinogenesis, altered; transcription, induced; signaling pathway regulation 31825826 3 0 0 TAZ target genes transcription and drives lung cancer brain metastases +Chek1 Chk1 EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, CAMK; Protein kinase, Ser/Thr (non-receptor); Tumor suppressor O35280 12649 9|9 A4 mouse S317-p 447833 ETVKFSSsQPEPRTG intracellular localization cell cycle regulation 17242188 103 11 17 +DVL2 DVL2 Adaptor/scaffold; Motility/polarity/chemotaxis O14641 1856 17p13.1 human S435-p 1873559808 KAMAAPEsGLEVRDR molecular association, regulation; protein conformation transcription, induced; signaling pathway regulation DVL2(INDUCES) 34155117 1 1 0 regulates Wnt Signaling +TP53 p53 Activator; DNA-binding; Motility/polarity/chemotaxis; Nuclear receptor co-regulator; Transcription factor; Tumor suppressor P04637 7157 17p13.1 human K120-ub 486293 FLHSGTAkSVTCTYS P53 protein degradation; intracellular localization 17371868; 31492752 2 3 18 +NME1 NME1 EC 2.7.4.6; KINASE; Kinase, nucleoside diphosphate; Kinase, other; Nucleotide Metabolism - purine; Nucleotide Metabolism - pyrimidine; Protein kinase, histidine; Tumor suppressor P15531 4830 17q21.33 human S120-p 450098 GRNIIHGsDSVESAE NDK molecular association, regulation; protein conformation; enzymatic activity, induced cell growth, altered PRUNE(INDUCES) 10602478; 12859952; 17155928; 9038158 6 21 0 inhibits colony formation in soft agar +ARNT ARNT DNA-binding; Motility/polarity/chemotaxis; Transcription factor P27540 405 1q21.3 human S77-p 458309 DKERFARsDDEQSSA protein stabilization; molecular association, regulation; intracellular localization; activity, inhibited transcription, induced; signaling pathway regulation; transcription, inhibited ARNT(INDUCES) 16129408; 34912030; 35290121 3 28 5 +CMKLR1 CMKLR1 GPCR, family 1; Membrane protein, integral; Membrane protein, multi-pass; Receptor, GPCR Q99788 1240 12q23.3 human S345-p 4713121 LSEDTGHsSYPSHRS receptor internalization, induced 24658352 1 1 0 +NADK2 NADK2 EC 2.7.1.23 Q4G0N4 133686 5p13.2 human K304-ac 1195255 DGPWEKQkSSGLNLC enzymatic activity, induced 35868311 1 1 2 K76Q and K304Q mutants reduced proline production, K76Q and K304Q mutants and S116A showed reduced catalytic activity, phosphorylation, succinylation, or acetylation could generate a charge repulsion in the active site +TTK TTK Cancer Testis Antigen (CTA); EC 2.7.12.1; KINASE; Kinase, protein; Protein kinase, Other; Protein kinase, dual-specificity (non-receptor) P33981 7272 6q14.1 human T360-p 1737602 SITLKNKtESSLLAK intracellular localization cell cycle regulation 25265012 3 3 0 autophosphorylation of this site is required for release TTK from kinetochore; causes decreased kinetochore localization of BubR1 and Mad2. +DSP Desmoplakin Cell adhesion; Cytoskeletal; Motility/polarity/chemotaxis P15924 1832 6p24.3 human S2849-p 451165 RSGSRRGsFDATGNS molecular association, regulation cytoskeletal reorganization; cell adhesion, inhibited 25010392; 7525582 3 5 1 DP-S2849G-GFP decreased Dsg3 expression, keratin retraction, increases association of PKC with Rack1; Desmoplakin S2849 phosphorylation may negatively regulate its interaction with the networks of keratin intermediate filaments. +NCOA3 SRC-3 ACETYLTRANSFERASE; Acetyltransferase; EC 2.3.1.48; Motility/polarity/chemotaxis; Nuclear receptor co-regulator; Transcription, coactivator/corepressor Q9Y6Q9 8202 20q13.12 human S1048-p 4252803 PSNLEGQsDERALLD Nuc_rec_co-act protein stabilization; molecular association, regulation PSMA3(DISRUPTS) 18313384 1 0 0 some subset of these 8 residues +FOXA1 FOXA1 DNA-binding; Transcription factor P55317 3169 14q21.1 human K237-ac 11263052 KVARSPDkPGKGSYW Forkhead molecular association, regulation chromatin organization, altered DNA(DISRUPTS) 19897491 1 0 0 +Gabbr2 GABBR2 GPCR, family 3; Membrane protein, integral; Membrane protein, multi-pass; Receptor, GPCR O88871 83633 5q22 rat S883-p 456824 DPIEDINsPEHIQRR signaling pathway regulation 30411139 0 11 4 +STK3 MST2 Autophagy; EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, STE; Protein kinase, Ser/Thr (non-receptor) Q13188 6788 8q22.2 human S385-p 4274113 TMKRNATsPQVQRPS ubiquitination; intracellular localization; phosphorylation cell cycle regulation; carcinogenesis, induced; cell growth, induced 27566175; 37739411 2 27 8 TRIM69 regulates centrosome dynamics and mitotic progression and centrosome amplification, regulates centrosome clustering, promotes triple-negative breast cancer; TRIM69A regulates MST2 ubiquitination and intracellular localization +ATR ATR EC 2.7.11.1; KINASE; Kinase, protein; Membrane protein, integral; Protein kinase, Ser/Thr (non-receptor); Protein kinase, atypical Q13535 545 3q23 human S435-p 477846 SPKRRRLsSSLNPSK molecular association, regulation DNA repair, induced; chromatin organization, altered; signaling pathway regulation XPA(INDUCES); AKAP12(INDUCES) 24950377; 27683220 3 29 72 MC1R signaling enhances NER ; MC1R-cAMP-PKA pathway; suppress UV induced mutagenesis +Slc2a1 GLUT1 Membrane protein, integral; Membrane protein, multi-pass; Transporter; Transporter, SLC family P11167 24778 5q36 rat S226-p 10827359 NEENRAKsVLKKLRG Sugar_tr activity, induced 25982116 1 6 1 glucose uptake +OCLN occludin Cell adhesion; Membrane protein, integral; Membrane protein, multi-pass; Motility/polarity/chemotaxis Q16625 100506658 5q13.2 human S471-p 6094301 LDDYREEsEEYMAAA Occludin_ELL cell growth, induced 27185880 1 1 0 size reductive proliferation after cell contact and bicellular and tricellular tite junction (TJ) maturation, TJ assembly and barrier formation +ARAF ARAF EC 2.7.11.1; KINASE; Kinase, protein; Oncoprotein; Protein kinase, Ser/Thr (non-receptor); Protein kinase, TKL P10398 369 Xp11.3 human S582-p 481007 PKIERSAsEPSLHRT enzymatic activity, induced 18662992 1 69 9 +USP24 USP24 DEUBIQUITINASE; EC 3.4.19.12; Protease; Ubiquitin-specific protease Q9UPU5 23358 1p32.3 human S1616-p 22547101 NSHSPAGsAAISQQD protein degradation cell cycle regulation 27991932 1 2 0 +Cebpb C/EBP-beta DNA-binding; Motility/polarity/chemotaxis; Transcription factor P21272 24253 3q42 rat S105-p 448425 AKPSKKPsDYGYVSL molecular association, regulation cell cycle regulation; cell growth, altered CASP8(INDUCES); CASP1(INDUCES) 10635333; 11684016 5 0 0 +TBK1 TBK1 EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, Other; Protein kinase, Ser/Thr (non-receptor) Q9UHD2 29110 12q14.2 human S527-p 50318715 QDIDSRLsPGGSLAD TBK1_CCD1 protein degradation; ubiquitination transcription, inhibited NALP4(INDUCES) 26407194 1 0 0 inhibited the TBK1-mediated activation of the ISRE and the IFN promoter +Tnnc1 TNNC1 Calcium-binding; Motility/polarity/chemotaxis Q4PP99 rat S89-p 33406500 VRCMKDDsKGKSEEE protein conformation 24708997 1 0 0 T204E mutant blunts Ca2+ sensitivity, PKC phosphorylation of these residues can increase or decrease Ca2+ sensitivity and cardiac regulation +EEF1A1 EEF1A1 Nucleolus; Translation; Translation elongation P68104 1915 6q13 human K36-me 1067201 YKCGGIDkRTIEKFE GTP_EFTU translation, induced 28520920 2 2 0 +Mapt Tau ACETYLTRANSFERASE; Acetyltransferase; Cytoskeletal P19332 29477 10q32.1 rat S573-p 447930 NVRSKIGsTENLKHQ Tubulin-binding molecular association, regulation cytoskeletal reorganization 18245083; 28784767 118 25 2 +Arpp21 ARPP-21 Inhibitor Q9DCB4 74100 9 F3|9 62.46 cM mouse S55-p 1096600 QNQERRKsKSGAGKG molecular association, regulation signaling pathway regulation Calmodulin(INDUCES) 15499021 2 0 0 Regulates PP2B suppression and PKA activation of calcium currents. +TBL1XR1 TBL1XR1 Nuclear receptor co-regulator; Transcription, coactivator/corepressor Q9BZK7 79718 3q26.32 human S199-p 2509603 TARIWNLsENSTSGS transcription, induced 18374649 1 0 0 +Nfya NFYA DNA-binding; Transcription factor P23708 18044 17 C|17 23.99 cM mouse K296-ub 4664703 KIPKERRkYLHESRH CBFB_NFYA protein degradation cell growth, inhibited; transcription, inhibited 18815279 1 0 0 +BLNK BLNK Adaptor/scaffold Q8WV28 29760 10q24.1 human Y72-p 447718 SDDFDSDyENPDEHS molecular association, regulation transcription, altered PLCG1(INDUCES); PLCG2(INDUCES); Btk(INDUCES); NCK2(INDUCES); VAV1(INDUCES) 12456653; 9697839 3 1 0 +GAB2 GAB2 Adaptor/scaffold Q9UQC2 9846 11q14.1 human S623-p 454021 ALDFQPSsPSPHRKP molecular association, regulation SHP-2(DISRUPTS) 15356145 2 6 14 Phosphorylation of this site decreases Gab2 interaction with SHP-2, but leads to increased SHP-2 phosphorylation and activation; also increased phosphorylation of ERK, but decreased activation of STAT5. +TERT TERT iso3 DNA-binding; EC 2.7.7.49; Nucleolus; Transferase O14746-3 7015 5p15.33 human K236-ub 14561001 SRSLPLPkRPRRGAA protein degradation chromatin organization, altered; apoptosis, induced 20453884 1 0 0 +PFN1 profilin 1 Actin-binding; Cytoskeletal; Motility/polarity/chemotaxis P02584 513895 cow Y129-p 450514 GMINKKCyEMASHLR Profilin molecular association, regulation cell motility, induced ACTB(INDUCES) 23000962 4 25 658 promotes actin filament polymerization in vitro +MAPK13 P38D EC 2.7.11.24; KINASE; Kinase, protein; Protein kinase, CMGC; Protein kinase, Ser/Thr (non-receptor) O15264 5603 6p21.31 human Y182-p 454935 ADAEMTGyVVTRWYR Pkinase enzymatic activity, induced 10066767 4 22 997 +Scg5 7B2 Chaperone; Secreted; Secreted, signal peptide P27682 25719 3q35 rat T135-p 25728419 CLENAPDtAEFSREF Secretogranin_V enzymatic activity, induced 25811241 1 2 1 PCSK2 activation +MRE11 MRE11A Cell cycle regulation; DNA repair, damage; DNA-binding; Deoxyribonuclease P49959 4361 11q21 human S649-p 455765 EVIEVDEsDVEEDIF cell cycle regulation; DNA repair, inhibited 28512243 2 38 2 +CENPU CENPU Cell cycle regulation Q71F23 79682 4q35.1 human T98-p 460338 CGLSLSStPPGKEAK molecular association, regulation PLK1(INDUCES) 34551298 1 11 26 +TLX1 TLX1 DNA-binding; Oncoprotein P31314 3195 10q24.31 human T247-p 15660705 MTDAQVKtWFQNRRT Homeodomain molecular association, regulation cell cycle regulation; transcription, altered DNA(NOT_REPORTED) 20846384 1 0 0 +SLC40A1 SLC40A1 Membrane protein, integral; Membrane protein, multi-pass; Transporter; Transporter, SLC family Q9NP59 30061 2q32.2 human Y302-p 25589103 FRDGWVSyYNQPVFL FPN1; TM receptor internalization, inhibited 22682226 1 0 0 regulates internalization partially but not hepcidin mediated internalization +Creb1 CREB iso1 DNA-binding; Transcription factor P15337-1 81646 9q32 rat K136-ac 459099 SRRPSYRkILNDLSS pKID transcription, inhibited 12595525 4 0 0 modulating CREB-mediated gene expression +RPS6KA4 MSK2 EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, AGC; Protein kinase, Ser/Thr (non-receptor) O75676 8986 11q13.1 human T687-p 455803 RSSPPLRtPDVLESS enzymatic activity, induced 11035004 1 26 3 +Fmnl2 FMNL2 Cytoskeletal A2APV2 71409 2|2 C1.1 mouse T202-p 4689209 HSALRYNtLPSRRTL cytoskeletal reorganization 25456499 1 6 1 spine development +ELMO1 ELMO1 Cytoskeletal; Motility/polarity/chemotaxis Q92556 9844 7p14.2-p14.1 human Y511-p 455873 SKLQNLSyTEILKIR molecular association, regulation; intracellular localization cytoskeletal reorganization NCK1(INDUCES); RHOG(INDUCES) 15952790; 24928514 4 2 1 mutation of this site impairs cell migration and phagocytosis; Nck1 enhances ELMO1 and RhoG interaction and promotes Rac1 activity; localization of ELMO1 to the plasma membrane +SIRT2 SIRT2 DEACETYLASE; Deacetylase; EC 3.5.1.- Q8IXJ6 22933 19q13.2 human T101-p 31839907 PDFRSPStGLYDNLE SIR2 molecular association, regulation Akt1(INDUCES) 24446434 1 0 0 +Stx3 STX3 Cell adhesion; Membrane protein, integral; Vesicle Q64704 20908 19|19 A mouse T14-p 31960301 QLKAKQLtQDDDTDE exocytosis, induced 33192329 5 1 0 +PRNP PRNP Membrane protein, GPI anchor; Microtubule-binding P04156 5621 20p13 human S43-p 10273948 SRYPGQGsPGGNRYP protein conformation 25572400 2 2 0 exacerbate PRNP mutant conversion +NIFK NIFK Nucleolus; RNA-binding Q9BYG3 84365 2q14.3 human T234-p 449332 TVDSQGPtPVCTPTF hNIFK_binding molecular association, regulation KI-67(INDUCES) 11342549; 16244663 2 27 77 +Cacng2 Stargazin Channel, calcium; Membrane protein, integral; Membrane protein, multi-pass Q71RJ2 84347 7q34 rat S247-p 455319 SSRSTEPsHSRDASP molecular association, regulation neural plasticity PSD-95(INDUCES) 25843401 3 0 0 +GATA1 GATA1 DNA-binding; Transcription factor P15976 2623 Xp11.23 human K245-ac 466357 NRPLIRPkKRLIVSK molecular association, regulation transcription, altered DNA(INDUCES) 16888089 3 1 0 +PRKCZ PKCZ EC 2.7.11.13; KINASE; Kinase, protein; Protein kinase, AGC; Protein kinase, Ser/Thr (non-receptor) Q05513 5590 1p36.33 human T560-p 447572 TSEPVQLtPDDEDAI Pkinase_C protein conformation; phosphorylation carcinogenesis, induced; cytoskeletal reorganization; signaling pathway regulation TNNI1(INDUCES); desmin(INDUCES); TPM1(INDUCES); MYO1C(INDUCES); TNNT1(INDUCES) 17724026; 25002577; 32559461 13 8 0 regulates mTORC2-PKC?-cPLA2 signaling +IRF3 IRF3 DNA-binding; Transcription factor Q14653 3661 19q13.33 human S385-p 448696 MARVGGAsSLENTVD activity, induced; molecular association, regulation; intracellular localization; protein conformation; enzymatic activity, induced transcription, induced; transcription, altered CBP(DISRUPTS); IRF3(INDUCES); p300(INDUCES) 10920266; 14703513; 17526488; 18272581; 18440553; 31882361; 35948267; 9463386 12 3 0 +CDC25C CDC25C EC 3.1.3.48; Motility/polarity/chemotaxis; PHOSPHATASE; Protein phosphatase, dual-specificity P30307 995 5q31.2 human T236-p 451436 VEKFKDNtIPDKVKK M-inducer_phosp molecular association, regulation; intracellular localization KPNB3(DISRUPTS) 15064744 1 0 0 +MAFG MAFG Cell cycle regulation; DNA-binding O15525 4097 17q25.3 human K14-sm 12004419 GNKALKVkREPGENG transcription, inhibited 16738329 1 2 0 +GSTP1 GSTP1 EC 2.5.1.18; Other Amino Acids Metabolism - glutathione; Transferase; Xenobiotic Metabolism - drug metabolism - cytochrome P450; Xenobiotic Metabolism - metabolism by cytochrome P450 P09211 2950 11q13.2 human S185-p 455118 SAYVGRLsARPKLKA GST_C_3 activity, induced; molecular association, regulation; intracellular localization HMGB1(INDUCES) 15604283; 29520271 2 0 0 nuclear translocation +Nfkb1 NFkB-p105 DNA-binding; Transcription factor P25799 18033 3 G3|3 62.82 cM mouse S335-p 449967 FVQLRRKsDLETSEP RHD_dimer molecular association, regulation; protein conformation transcription, altered NFkB-p105(DISRUPTS) DNA(DISRUPTS) 29873020 5 1 0 +MAP2K1 MEK1 EC 2.7.12.2; KINASE; Kinase, protein; Protein kinase, STE; Protein kinase, dual-specificity (non-receptor) Q02750 5604 15q22.31 human T388-p 466978 LNQPSTPtHAAGV__ intracellular localization 18760948 2 1 15 nuclear translocation +ACSL4 ACSL4 EC 6.2.1.3; Ligase; Lipid Metabolism - fatty acid; Membrane protein, integral O60488 2182 Xq23 human K690-ub 21128156 GLVTDAFkLKRKELR protein degradation 37428466 1 2 0 inhibition of ACSL4-driven lipid peroxidation and ferroptosis is necessary for CDK1 to promote oxaliplatin resistance in CRC +G3BP1 G3BP-1 Adaptor/scaffold; EC 3.6.4.12; EC 3.6.4.13; Helicase; RNA-binding Q13283 10146 5q33.1 human S149-p 449041 VTEPQEEsEEEVEEP molecular association, regulation; intracellular localization; activity, inhibited; protein conformation carcinogenesis, induced; cell motility, induced; cell growth, induced; apoptosis, inhibited; cytoskeletal reorganization G3BP-1(DISRUPTS); CAPRIN1(DISRUPTS); USP10(INDUCES) RNA(DISRUPTS) 11604510; 12642610; 27022092; 27083003; 32302571; 32302572; 33065005; 36922679 12 87 53 induces ESM1 stabilization +Irs2 IRS2 Adaptor/scaffold; Motility/polarity/chemotaxis P81122 384783 8 A1.1|8 5.35 cM mouse S556-p 470895 GRPYRRVsGDGAQDL protein degradation cell cycle regulation 25830382 2 51 10 +AQP5 AQP5 Channel, misc.; Membrane protein, integral; Membrane protein, multi-pass; Transporter; Transporter, aquaporin family P55064 362 12q13.12 human S156-p 1233703 STDSRRTsPVGSPAL MIP activity, induced; intracellular localization; phosphorylation cell cycle regulation; cell motility, induced LYN(INDUCES); Src(INDUCES); GADS(INDUCES) 18478076; 18583321; 26569106 5 0 0 increases posphorylation of Rb at S780; S156 to glutamate (S156E) increased constitutive membrane expression of AQP5, increased membrane expression by PKA inhibitory peptide; affects cell proliferation; stimulates cells to undergo epithelial-mesenchymal transition (EMT) +MCM2 MCM2 DNA-binding; EC 3.6.4.12 P49736 4171 3q21.3 human S139-p 454180 RRGLLYDsDEEDEER MCM2_N activity, induced; molecular association, regulation cell cycle regulation; chromatin organization, altered SIRT1(INDUCES) DNA(NOT_REPORTED); DNA(INDUCES) 16446360; 16899510; 35524559 7 99 323 +STAT3 STAT3 DNA-binding; Motility/polarity/chemotaxis; Nuclear receptor co-regulator; Transcription factor P40763 6774 17q21.2 human K451-sm 56403902 EVYHQGLkIDLETHS STAT_bind molecular association, regulation; phosphorylation carcinogenesis, inhibited; transcription, inhibited PTPN2(INDUCES) 27181202 1 0 0 SENP deconjugates SUMO and inhibits STAT3 association with phosphatase PTPN2, enhancing phosphorylation at Y705 +TRPA1 TRPA1 Membrane protein, integral; Membrane protein, multi-pass O75762 8989 8q21.11 human S602-p 1871177701 VVLTIIRsKRWDECL Ank_2 protein conformation; activity, inhibited 33121177 1 0 0 inactivate human TRPA1 channel +MAF1 MAF1 Transcription regulation Q9H063 84232 8q24.3 human S75-p 477954 SPSRLSKsQGGEEEG Maf1 protein degradation; ubiquitination; activity, inhibited transcription, induced; transcription, altered 20233713; 20516213; 20543138; 31645432 4 33 54 regulates sensitivity of cells for doxorubicin +NFKBIA IkB-alpha DNA-binding; Inhibitor P25963 4792 14q13.2 human K22-ub 485774 GPRDGLKkERLLDDR activity, induced; protein degradation; ubiquitination; intracellular localization transcription, induced 7479976; 8550590; 8649784; 9724653; 9990853 9 0 0 +DYRK2 DYRK2 iso2 EC 2.7.12.1; KINASE; Kinase, protein; Protein kinase, CMGC; Protein kinase, dual-specificity (non-receptor) Q92630-2 8445 12q15 human S489-p 1874397816 ESTGAITsISKLPPP intracellular localization cell cycle regulation; apoptosis, induced 34363019 1 1 0 +SMN1 SMN RNA processing; RNA-binding Q16637 6606 5q13.2 human T68-p 23299103 ETSGKPKtTPKRKPA SMN molecular association, regulation; intracellular localization coilin(INDUCES) 24602413 1 1 1 +APP APP Apoptosis; Cell surface; Membrane protein, integral; Receptor, misc.; Transcription factor P05067 351 21q21.3 human K751-ub 3932067 PEERHLSkMQQNGYE APP_amyloid protein processing; intracellular localization 29021256 2 8 39 An APP mutant that lacks all C-terminal lysines increased PSEN2-mediated processing of an increased pool of APP on the endosomal membrane. +Arpp19 ARPP-19 Cell cycle regulation; Phosphatase, regulatory subunit P56212 59046 9|9 D mouse S62-p 465742 KGQKYFDsGDYNMAK Endosulfine enzymatic activity, inhibited 28167675 3 70 47 inhibits PP2A activity +CLOCK CLOCK ACETYLTRANSFERASE; Acetyltransferase; DNA-binding; EC 2.3.1.48; Transcription factor O15516 9575 4q12 human S431-p 11087834 FDHSPTPsASSRSSR protein degradation; phosphorylation transcription, altered 19946213 1 1 0 +NEU3 NEU3 EC 3.2.1.18; Glycan Metabolism - other glycan degradation; Hydrolase; Lipid Metabolism - sphingolipid Q9UQ49 10825 11q13.4 human Y346-p 450320 QRVDLGIyLNQTPLE BNR_2 molecular association, regulation; phosphorylation GRB2(INDUCES) 12730204 1 0 0 lowers IRS-1 phosphorylation +CTTN Cortactin Actin-binding; Cytoskeletal; Motility/polarity/chemotaxis Q14247 2017 11q13.3 human T401-p 449245 QARAKTQtPPVSPAP intracellular localization 27758765 2 95 117 +PRKCA PKCA EC 2.7.11.13; KINASE; Kinase, protein; Oncoprotein; Protein kinase, AGC; Protein kinase, Ser/Thr (non-receptor) P17252 5578 17q24.2 human S657-p 448597 QSDFEGFsYVNPQFV Pkinase_C intracellular localization; phosphorylation; enzymatic activity, induced carcinogenesis, induced; cell growth, induced; cytoskeletal reorganization; signaling pathway regulation 17504762; 22521536; 35132180 28 4 2 +Opn4 melanopsin GPCR, family 1; Membrane protein, integral; Membrane protein, multi-pass; Receptor, GPCR Q9QXZ9 30044 14|14 B mouse S379-p 1868515103 SGQRSHPsLSYRSTH protein conformation 32236094 1 1 0 +PRL prolactin Cytokine; Motility/polarity/chemotaxis; Secreted; Secreted, signal peptide P01236 5617 6p22.3 human S179-p 17790903 NEIYPVWsGLPSLQM Hormone_1 phosphorylation cell cycle regulation; apoptosis, induced; cell growth, inhibited; transcription, induced; cell motility, inhibited; transcription, inhibited; signaling pathway regulation 12970160; 16103106; 16601282; 16840547; 17911340; 20013077 9 0 0 upregulates p21; ; upregulates VDR and promotes its nuclear translocation +WRN WRN Cell cycle regulation; DNA repair, damage; DNA-binding; EC 3.6.4.12; Helicase; Nucleolus Q14191 7486 8p12 human K1413-ac 486391 RLPVWFAkGSDTSKK protein stabilization; ubiquitination 20428248 1 1 0 inhibits ubiquitination +ALDH1B1 ALDH1B1 Amino Acid Metabolism - arginine and proline; Amino Acid Metabolism - histidine; Amino Acid Metabolism - lysine degradation; Amino Acid Metabolism - tryptophan; Amino Acid Metabolism - valine, leucine and isoleucine degradation; Carbohydrate Metabolism - ascorbate and aldarate; Carbohydrate Metabolism - butanoate; Carbohydrate Metabolism - glycolysis and gluconeogenesis; Carbohydrate Metabolism - propanoate; Carbohydrate Metabolism - pyruvate; EC 1.2.1.3; Lipid Metabolism - fatty acid; Lipid Metabolism - glycerolipid; Mitochondrial; Other Amino Acids Metabolism - beta-alanine; Oxidoreductase; Secondary Metabolites Metabolism - limonene and pinene degradation P30837 219 9p13.1 human K511-ub 1881380902 EVKTVTIkVPQKNS_ molecular association, regulation transcription, inhibited ALDH1B1(DISRUPTS) 34769507 1 0 0 AMBRA1-mediated ubiquitylation of ALDH1B1 inhibitss the self-association of ALDH1B1 and the transcription of PTEN +TPX2 TPX2 Cell cycle regulation; Microtubule-binding Q9ULW0 22974 20q11.21 human T369-p 455432 KICRDPQtPVLQTKH TPX2_importin activity, induced; intracellular localization cell cycle regulation 27551054 2 25 129 recruitment to the anaphase spindle +AXIN1 axin 1 iso2 Adaptor/scaffold; Tumor suppressor O15169-2 8312 16p13.3 human K789-ub 40212803 GSYRYYFkKVSDEFD DIX molecular association, regulation signaling pathway regulation LRP5(DISRUPTS); LRP6(DISRUPTS) 23959799 1 0 0 regulates Wnt/beta-catenin signaling, inhibits LRP6 phosphorylation +IRF3 IRF3 DNA-binding; Transcription factor Q14653 3661 19q13.33 human K70-sm 25174502 AYVPGRDkPDLPTWK IRF protein stabilization; ubiquitination 22028379 1 0 0 deSUMOylation promotes ubiquitination and degradation at the same residues +NADK NADK Cofactor and Vitamin Metabolism - nicotinate and nicotinamide; EC 2.7.1.23; Kinase, other O95544 65220 1p36.33 human S46-p 1210510 RGRAKSRsLSASPAL phosphorylation; enzymatic activity, induced carcinogenesis, induced 34133937 1 22 8 primes for phosphorylation at S64 +ERBB4 HER4 EC 2.7.10.1; KINASE; Kinase, protein; Membrane protein, integral; Protein kinase, TK; Protein kinase, tyrosine (receptor) Q15303 2066 2q34 human Y1284-p 457470 IVAENPEyLSEFSLK molecular association, regulation; enzymatic activity, induced cell growth, induced; apoptosis, inhibited SHC1(INDUCES) 16729043; 19718025 6 2 7 +PLN PLB Inhibitor; Membrane protein, integral P61015 rabbit S16-p 448114 RSAIRRAsTIEMPQQ Phospholamban activity, induced 21555709 78 15 66 induces SERCA2 activity +YWHAE 14-3-3 epsilon Adaptor/scaffold P62258 7531 17p13.3 human K50-ac 11315836 NLLSVAYkNVIGARR 14-3-3 molecular association, regulation; intracellular localization SFRS6(DISRUPTS); PLEKHQ1(DISRUPTS); SFRS4(DISRUPTS); DOK3(DISRUPTS); TSC2(DISRUPTS); ARAF(DISRUPTS); LARP(DISRUPTS); SRm300(DISRUPTS); SF2(DISRUPTS); TSC22D1(DISRUPTS); YAP1(DISRUPTS); GAB2(DISRUPTS); RAF1(DISRUPTS); VASP(DISRUPTS); HDAC4(DISRUPTS); TRA2B(DISRUPTS); GBF1(DISRUPTS) 19608861; 36341908 1 4 13 +SNAP23 SNAP23 Vesicle O00161 8773 15q15.1-q15.2 human S95-p 455262 NRTKNFEsGKAYKTT SNAP-25 molecular association, regulation; intracellular localization; protein conformation autophagy, induced; exocytosis, induced; endocytosis, inhibited STX17(INDUCES) 28067230; 29771640; 32949647; 33213278 14 4 2 +Sdha SDHA Carbohydrate Metabolism - citrate (TCA) cycle; EC 1.3.5.1; Energy Metabolism - oxidative phosphorylation; Mitochondrial; Oxidoreductase; Tumor suppressor Q8K2B3 66945 13|13 C1 mouse Y604-p 1458603 YKVRVDEyDYSKPIQ Succ_DH_flav_C activity, induced 24856931 3 2 2 induce complex II activation +CEACAM1 CEACAM1 iso8 Cell adhesion; Immunoglobulin superfamily; Membrane protein, integral; Motility/polarity/chemotaxis P13688-8 634 19q13.2 human T457-p 3439801 CFLHFGKtGSSGPLQ phosphorylation cell differentiation, altered 17546042 5 1 0 FAK Y397 phosphorylation +ERF ERF DNA-binding; Transcription factor P50548 2077 19q13.2 human S246-p 456967 RGGPEPLsPFPVSPL intracellular localization cell cycle regulation 10330152; 14729966 2 1 0 +Nos1 nNOS Amino Acid Metabolism - arginine and proline; EC 1.14.13.39; Oxidoreductase P29476 24598 12q16 rat K754-ac 2459107 QAMAKRVkATILYAT activity, induced 18415985 1 1 0 +PKD1 PKD1 Cell adhesion; Membrane protein, integral; Membrane protein, multi-pass P98161 5310 16p13.3 human S4166-p 2859800 EPLPSRSsRGSKVSP cell differentiation, altered 17980165 1 0 0 +Stk11 LKB1 Autophagy; EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, CAMK; Protein kinase, Ser/Thr (non-receptor); Tumor suppressor Q9WTK7 20869 10|10 C1 mouse Y36-p 14575494 IDSTEVIyQPRRKRA molecular association, regulation; intracellular localization cell differentiation, induced; signaling pathway regulation PLCG1(INDUCES); LAT(INDUCES) 21487392 1 5 12 TCR signaling, recruitment of PLCG1 to the LAT signalosome +NQO1 NQO1 EC 1.6.5.2; Oxidoreductase P15559 1728 16q22.1 human S40-p 23255660 KGWEVVEsDLYAMNF Flavodoxin_2 protein degradation; protein conformation 36096178 2 0 1 +EZH2 EZH2 EC 2.1.1.43; METHYLTRANSFERASE; Methyltransferase; Methyltransferase, protein lysine Q15910 2146 7q36.1 human T345-p 4957354 LTAERIKtPPKRPGG protein degradation; molecular association, regulation; ubiquitination; protein conformation carcinogenesis, induced; carcinogenesis, altered; cell growth, induced; cell motility, altered; transcription, altered; cell growth, altered SUZ12(INDUCES); H3(INDUCES); AR(INDUCES) RNA(INDUCES) 20935635; 21659531; 25800736; 27716745; 34489572; 35682829 11 12 2 +STING1 STING Apoptosis; Endoplasmic reticulum; Membrane protein, integral; Membrane protein, multi-pass; Mitochondrial Q86WV6 340061 5q31.2 human S358-p 13201900 VPSTSTMsQEPELLI activity, induced; molecular association, regulation TBK1(INDUCES) 18818105; 22579474 4 1 0 with c-di-GMP, S358A shows weaker binding; activates IRF-E and enhances interaction between TBK1 and IRF3.; truncated STING (residues 139?344 only) showed additional binding sites +IRF2 IRF2 DNA-binding; Transcription factor P14316 3660 4q35.1 human K75-ac 459110 GVDKPDPkTWKANFR IRF cell growth, induced; transcription, induced 12738767 1 1 0 acetylated in a cell growth-dependent manner +Ocln occludin Cell adhesion; Membrane protein, integral; Membrane protein, multi-pass; Motility/polarity/chemotaxis Q61146 18260 13 D1|13 53.23 cM mouse S489-p 6094300 RLKQVKGsADYKSKR Occludin_ELL intracellular localization endocytosis, induced; cell motility, induced; cell growth, induced 27423695; 33883214 11 1 0 VEGF-induced tube formation, VEGF-induced tube formation, localizes to centrosomes, retinal neovascularization; regulates VEGF induced retinal permeability, BRB permeability and leukostasis induced by diabetes +LRP1 LRP1 Cell surface; Membrane protein, integral; Motility/polarity/chemotaxis; Receptor, misc. Q07954 4035 12q13.3 human Y4507-p 451245 TNFTNPVyATLYMGG molecular association, regulation; protein conformation SHC1(INDUCES); SHP-2(INDUCES); Fe65(INDUCES) 11854294; 18381291; 21650223 6 1 0 only binds when Fe65 is in complex with APP +SHC3 SHC3 iso2 Adaptor/scaffold; Motility/polarity/chemotaxis Q92529-2 53358 9q22.1 human Y283-p 451257 RQGSSDIySTPEGKL molecular association, regulation CRK(INDUCES); RAPGEF1(INDUCES) 11791173 1 3 27 +AGTR1 AT1 GPCR, family 1; Membrane protein, integral; Membrane protein, multi-pass; Receptor, GPCR P30556 185 3q24 human S335-p 467238 SNLSTKMsTLSYRPS activity, induced; molecular association, regulation; intracellular localization; receptor internalization, altered ARRB1(INDUCES); ARRB2(INDUCES) 11579203; 15177932 3 1 0 +CERK CERK EC 2.7.1.138; Kinase, lipid; Lipid Metabolism - sphingolipid Q8TCT0 64781 22q13.31 human S427-p 11485304 LILIRKCsRFNFLRF CERK_C enzymatic activity, induced 19899769 1 0 0 +DAB2 DAB2 Adaptor/scaffold; Tumor suppressor P98082 1601 5p13.1 human S393-p 483635 QNGFSVKsSPNPFVG molecular association, regulation CLTA(INDUCES) 21097498 1 5 0 +Crtc2 TORC2 Transcription, coactivator/corepressor Q3U182 74343 3|3 F1 mouse S275-p 3174300 PAMNTGGsLPDLTNL TORC_M molecular association, regulation; intracellular localization carcinogenesis, inhibited; transcription, inhibited; transcription, altered 14-3-3 beta(INDUCES) 18626018; 26342077; 29941929; 33127851 6 0 0 +HDAC6 HDAC6 DEACETYLASE; Deacetylase; EC 3.5.1.98; Nuclear receptor co-regulator; Ubiquitin conjugating system Q9UBN7 10013 Xp11.23 human S22-p 453006 RSRQNPQsPPQDSSV molecular association, regulation; acetylation; enzymatic activity, induced Tau(INDUCES); SNCA(INDUCES) 31363957; 32655357 5 35 18 +PCK2 PCK2 Carbohydrate Metabolism - citrate (TCA) cycle; Carbohydrate Metabolism - glycolysis and gluconeogenesis; Carbohydrate Metabolism - pyruvate; EC 4.1.1.32; Kinase, other; Lyase; Mitochondrial Q16822 5106 14q11.2-q12 human K491-ac 54531208 AAAEHKGkIIMHDPF PEPCK_GTP protein stabilization carcinogenesis, induced; signaling pathway regulation 34166767 1 2 0 Isoenzyme transition from PCK1 to PCK2; gluconeogenesis from glutamine and lactate enhanced tolerance to sorafenib; development of sorafenib-resistant liver cancer cell; nonacetylated form of PCK2 was degraded via lysosomes +Creb1 CREB DNA-binding; Transcription factor Q01147 12912 1 C2|1 32.74 cM mouse S119-p 448228 EILSRRPsYRKILND pKID activity, induced; acetylation; molecular association, regulation; protein conformation; phosphorylation carcinogenesis, induced; apoptosis, induced; transcription, induced; signaling pathway regulation; transcription, altered; neural plasticity; exocytosis, induced; autophagy, inhibited; transcription, inhibited; cell growth, altered; translation, inhibited CREM iso2(INDUCES); MyoD(INDUCES); SIRT1(INDUCES); p300(INDUCES); CREB(DISRUPTS); CBP(INDUCES) DNA(DISRUPTS) 10669737; 10722651; 12091337; 12665587; 15590637; 17196532; 17344422; 17616745; 18356083; 19041748; 20952540; 23241891; 26804914; 27095572; 32358047; 32776935; 32878981; 34171357; 34193609; 34348143; 34425033; 34607805; 34695513; 34750263; 36049536; 36090685; 36516759; 36736425; 36995368; 37028428; 8552098 311 5 61 in vitro and in vivo +EDNRA EDNRA GPCR, family 1; Membrane protein, integral; Membrane protein, multi-pass; Motility/polarity/chemotaxis; Receptor, GPCR P25101 1909 4q31.22-q31.23 human S420-p 2911706 NNHNTDRsSHKDSMN receptor desensitization, induced 24064210 1 1 0 Lack of S397, T403 and S404 influences desensitization to a greater extent compared than S391, S393, and T396 +DDR1 DDR1 EC 2.7.10.1; KINASE; Kinase, protein; Membrane protein, integral; Protein kinase, TK; Protein kinase, tyrosine (receptor) Q08345 780 6p21.33 human Y792-p 462055 FGMSRNLyAGDYYRV PK_Tyr_Ser-Thr activity, induced carcinogenesis, induced; cell adhesion, induced; signaling pathway regulation 24509848; 31979355 1 17 926 +Foxo3 FOXO3A Autophagy; DNA-binding; Oncoprotein; Transcription factor Q9WVH4 56484 10 B2|10 22.79 cM mouse S573-p 20799900 SAKHQQQsPASQSMQ activity, induced transcription, induced; signaling pathway regulation 33649241 5 2 0 upregulates miR-34b and miR-34c expression; inhibits PDGF pathway +Gria1 GluR1 Channel, calcium; Channel, ligand-gated; Membrane protein, integral; Membrane protein, multi-pass P23818 14799 11 B1.3|11 34.51 cM mouse S857-p 3362102 INEAIRTsTLPRNSG activity, induced 17689977 1 0 0 synaptic plasticity +Nbn NBS1 Cell cycle regulation; DNA repair, damage Q9R207 27354 4|4 A2 mouse T278-p 449968 VDVGITNtQLIISHS NIBRIN_BRCT_II DNA repair, induced 21664921 10 0 0 delayed phosphorylation of Chk2 and Smc1 +YBX1 YB-1 RNA processing; RNA splicing; RNA-binding; Transcription factor P67809 4904 1p34.2 human S165-p 469054 YQQNYQNsESGEKNE intracellular localization cell growth, induced; transcription, induced 26318844; 28077578 2 78 31 +EP300 p300 ACETYLTRANSFERASE; Acetyltransferase; EC 2.3.1.48; Motility/polarity/chemotaxis; Nuclear receptor co-regulator; Transcription, coactivator/corepressor Q09472 2033 22q13.2 human S1038-p 10941006 STSATQSsPAPGQSK protein degradation; acetylation cell cycle regulation; carcinogenesis, induced; chromatin organization, altered; cell motility, induced; cell growth, induced; transcription, inhibited 24530506 1 27 0 Decrease histone H3-acetylation +SMAD2 SMAD2 DNA-binding; Transcription factor Q15796 4087 18q21.1 human T220-p 448793 QSNYIPEtPPPGYIS activity, induced; protein stabilization; molecular association, regulation; intracellular localization carcinogenesis, induced; cell differentiation, induced; transcription, induced; signaling pathway regulation SETD2(INDUCES); SMAD4(INDUCES) RNA(INDUCES) 10197981; 12193595; 27153775; 31995604; 33051597 12 0 0 TGFB1 signaling +JUP CTNNG Cytoskeletal; Motility/polarity/chemotaxis P14923 3728 17q21.2 human Y550-p 456972 AAGTQQPyTDGVRME molecular association, regulation transcription, induced Desmoplakin(DISRUPTS); CTNNA1(INDUCES) 14517306 1 4 136 +TBK1 TBK1 EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, Other; Protein kinase, Ser/Thr (non-receptor) Q9UHD2 29110 12q14.2 human Y394-p 126839800 LNTIGLIyEKISLPK TBK1_ULD enzymatic activity, inhibited; protein conformation 28618271 2 1 0 suppress antiviral defenses +CD300LF IREM-1 Immunoglobulin superfamily; Membrane protein, integral; Receptor, misc. Q8TDQ1 146722 17q25.1 human Y284-p 474547 GPEEPTEySTISRP_ activity, induced; molecular association, regulation SHP-1(INDUCES) 17202342 2 0 0 mutation of site to Phe decreased the inhibitory activity of IREM-1 +NPHP1 NPHP1 Cell adhesion O15259 4867 2q13 human Y721-p 18449509 FDLSEQTyDFLGEMR molecular association, regulation; intracellular localization PACS-1(INDUCES) 21357692 1 0 0 +TPPP TPPP Cytoskeletal O94811 11076 5p15.33 human S32-p 456613 DRAAKRLsLESEGAG acetylation; phosphorylation transcription, induced 23727580 2 36 5 decreases B-Catennin phosphorylation and acetylation and induces its expression +NME1 NME1 EC 2.7.4.6; KINASE; Kinase, nucleoside diphosphate; Kinase, other; Nucleotide Metabolism - purine; Nucleotide Metabolism - pyrimidine; Protein kinase, histidine; Tumor suppressor P15531 4830 17q21.33 human K85-ub 15393712 WEGLNVVkTGRVMLG NDK protein degradation cell motility, induced 25582197 1 1 1 +Dcx Doublecortin iso3 Cytoskeletal; Motility/polarity/chemotaxis Q9CXL6 13193 X|X F2 mouse S327-p 451363 STPKSKQsPISTPTS cell motility, induced; cytoskeletal reorganization 25073924; 33405953 7 4 14 +ABI1 Abi-1 Adaptor/scaffold; Motility/polarity/chemotaxis Q8IZP0 10006 10p12.1 human K116-ac 1881343400 IGILTTNkNTSRTHK molecular association, regulation; phosphorylation N-WASP(INDUCES) 34369620 1 0 0 +Cacna1c CACNA1C iso5 Channel, calcium; Membrane protein, integral; Membrane protein, multi-pass Q0PCR6 12288 6 F1|6 55.86 cM mouse S1700-p 4714250 PEIRRAIsGDLTAEE CAC1F_C activity, induced 24218620; 25368181 17 7 0 increased channel current and contractility in response to beta-adrenergic stimulation, exercise capacity and cardiac function in vivo; channel activity, regulates fight-or-flight response, blocking induces cardiac hypertrophy +NCOA3 SRC-3 ACETYLTRANSFERASE; Acetyltransferase; EC 2.3.1.48; Motility/polarity/chemotaxis; Nuclear receptor co-regulator; Transcription, coactivator/corepressor Q9Y6Q9 8202 20q13.12 human K786-ub 1505897101 QEKDPKIkTETSEEG DUF4927 activity, induced; protein degradation; molecular association, regulation; ubiquitination transcription, induced; signaling pathway regulation ER-alpha(INDUCES) 17574025 1 0 0 +Tnnt2 TNNT2 Motility/polarity/chemotaxis; Motor P50752 21956 1 E4|1 59.32 cM mouse T297-p 451557 TRGKAKVtGRWK___ Troponin phosphorylation cytoskeletal reorganization 15774859 6 0 0 ROCK II induced desensitization to Ca++ and depression in maximal tension. +Cish CISH O70512 83681 8q32 rat K207-ub 37044802 VATAVHLkLVQPFVR protein degradation 25448846 1 0 0 +SNAI1 Snail1 C2H2-type zinc finger protein; Transcription factor O95863 6615 20q13.13 human K234-sm 1873356100 LQTHSDVkKYQCQAC molecular association, regulation; intracellular localization carcinogenesis, induced; cell motility, induced; transcription, induced Jun(INDUCES) 29228645 1 0 0 +HDAC4 HDAC4 DEACETYLASE; Deacetylase; EC 3.5.1.98; Hydrolase; Nuclear receptor co-regulator; SUMO LIGASE P56524 9759 2q37.3 human S298-p 1322400 ACSSAPGsGPSSPNN protein degradation; ubiquitination; intracellular localization cell motility, altered 18045992; 21118993 2 0 0 +Trpv1 TRPV1 Channel, cation; Membrane protein, integral; Membrane protein, multi-pass; Receptor, misc. Q704Y3 193034 11 B4|11 45.25 cM mouse T407-p 473576 IAYSSSEtPNRHDML activity, induced 23668392 5 0 0 potentiates Ca2+ influx +ACSS2 ACSS2 Carbohydrate Metabolism - glycolysis and gluconeogenesis; Carbohydrate Metabolism - propanoate; Carbohydrate Metabolism - pyruvate; EC 6.2.1.1; Ligase Q9NR19 55902 20q11.22 human S659-p 83970101 PGLPKTRsGKIMRRV AMP-binding_C molecular association, regulation; intracellular localization autophagy, induced; transcription, induced KPNA5(INDUCES) 28552616; 28820290 3 1 0 nuclear translocation +Tcf7 TCF7 DNA-binding; Transcription factor Q00417 21414 11 B1.3|11 31.86 cM mouse K99-ub 41496498 SQRLFPDkLPESLED CTNNB1_binding protein stabilization cell growth, induced 31488580 1 3 0 +DBNL DBNL Actin-binding; Motility/polarity/chemotaxis Q9UJU6 28988 7p13 human S269-p 467729 KQKERAMsTTSISSP molecular association, regulation signaling pathway regulation 14-3-3 beta(INDUCES); 14-3-3 theta(INDUCES); HPK1(INDUCES) 21725060; 36639542 2 65 464 inhibits the MAP4K1/JNK/GPX4 cell death pathway; mutation of this site prevents 14-3-3 binding (pan-14-3-3 antibody) +Kcnd2 Kv4.2 Channel, potassium; Membrane protein, integral; Membrane protein, multi-pass Q9Z0V2 16508 6 A2-A3.1|6 8.49 cM mouse K437-sm 1879723000 LARIRAAkSGSANAY intracellular localization 31213982 2 0 0 increase in Kv4.2 surface expression +DCP1A DCP1A EC 3.-.-.-; Hydrolase; RNA processing; Transcription, coactivator/corepressor Q9NPI6 55802 3p21.1 human S315-p 3213294 PTYTIPLsPVLSPTL intracellular localization RNA stability, induced; transcription, altered 21859862 4 29 10 +NAA10 NAA10 ACETYLTRANSFERASE; Acetyltransferase; Amino Acid Metabolism - phenylalanine; Amino Acid Metabolism - tyrosine; EC 2.3.1.88; Lipid Metabolism - glycerophospholipid; Secondary Metabolites Metabolism - limonene and pinene degradation P41227 8260 Xq28 human K136-ac 461869 QISEVEPkYYADGED enzymatic activity, induced carcinogenesis, induced; cell growth, induced; transcription, induced; signaling pathway regulation 20501853 2 4 11 regulates AP1 pathway activation mediated by ERK1/2 +Oxsr1 OSR1 EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, STE; Protein kinase, Ser/Thr (non-receptor) Q6P9R2 108737 9|9 F3 mouse T185-p 456503 TRNKVRKtFVGTPCW Pkinase enzymatic activity, induced cell motility, induced 21486947; 27400149 12 6 51 +GRB2 GRB2 Adaptor/scaffold; Cell development/differentiation; Motility/polarity/chemotaxis P62993 2885 17q25.1 human Y160-p 452038 QVPQQPTyVQALFDF molecular association, regulation; protein conformation cell growth, inhibited; cell growth, induced; signaling pathway regulation GRB2(DISRUPTS); EGFR(DISRUPTS) 26103942; 33795832; 35507881; 36163549 6 4 34 +DOCK2 DOCK2 Adaptor/scaffold; GAP; GAP, Rac/Rho; Motility/polarity/chemotaxis Q92608 1794 5q35.1 human Y1405-p 1876205002 VKNAPGQyIQCFTVQ DHR-2_Lobe_B molecular association, regulation; intracellular localization; enzymatic activity, induced transcription, induced; signaling pathway regulation RAC1(INDUCES) 35079145 1 1 0 induces RAC1 GTPase recruitment and activation further inducing CLR signaling +IRX2 IRX2 DNA-binding; Transcription factor Q9PU52 373975 chicken S326-p 452193 AALGGRAsPGPPTPA transcription, altered 15133517 1 1 0 +UIMC1 RAP80 Nuclear receptor co-regulator; Transcription, coactivator/corepressor Q96RL1 51720 5q35.2 human K112-ub 573781876 EEEELLRkAIAESLN RAP80_UIM intracellular localization; enzymatic activity, inhibited 35938958 1 3 0 +Cnr1 CNR1 GPCR, family 1; Membrane protein, integral; Membrane protein, multi-pass; Receptor, GPCR P47746 12801 4 A5|4 16.28 cM mouse S465-p 22342302 AKVTMSVsTDTSAEA receptor desensitization, induced 22014214 1 0 1 +H2az1 H2AZ DNA-binding P0C0S6 51788 3|3 G3 mouse K115-ub 486330 GVIPHIHkSLIGKKG Histone_H2A_C protein degradation 16687393 1 9 13 +Kcnma1 KCNMA1 iso2 Channel, potassium; Endoplasmic reticulum; Membrane protein, integral; Membrane protein, multi-pass Q08460-2 16531 14|14 A3 mouse S899-p 469989 HGMLRQPsITTGVNI activity, induced 15280542 4 2 0 activation requires phosphorylation of the S899 site on each of the four subunits of the tetramer +CD6 CD6 Cell surface; Membrane protein, integral P30203 923 11q12.2 human S560-p 28095006 GPQYHPRsNSESSTS phosphorylation signaling pathway regulation 23711376 1 0 1 ERK1/2 phosphorylation, MAPK pathway activation +KCNK3 KCNK3 Channel, potassium; Membrane protein, integral; Membrane protein, multi-pass O14649 3777 2p23.3 human S393-p 2840504 GLMKRRSsV______ activity, induced; intracellular localization; activity, inhibited 21357689; 21838752 3 0 0 +Pak4 PAK4 EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, STE; Protein kinase, Ser/Thr (non-receptor) Q8BTW9 70584 7|7 B1 mouse S476-p 448023 KEVPRRKsLVGTPYW Pkinase phosphorylation; enzymatic activity, induced cell differentiation, inhibited; cell growth, induced; transcription, inhibited; signaling pathway regulation 34431242 13 66 140 induces phosphorylation of PPAR-gamma and regulates PI3K?Akt signalling +DAGLA NSDDR EC 3.1.1.-; Hydrolase; Membrane protein, integral; Membrane protein, multi-pass Q9Y4D2 747 11q12.2 human S808-p 27807806 RSIRGSPsLHAVLER enzymatic activity, inhibited 23502535 1 1 0 +TLR5 TLR5 Membrane protein, integral; Receptor, misc. O60602 7100 1q41 human Y798-p 473546 VVGSLSQyQLMKHQS TIR activity, induced transcription, induced 17157808; 25020193 2 1 0 +GCM1 GCM1 DNA-binding; Transcription factor Q9NP62 8521 6p12.1 human K367-ac 460587 AGNLYEEkVHVDFNS protein stabilization; ubiquitination transcription, induced 16166624 1 0 0 inhibits ubiquitination +Mcm3 MCM3 DNA replication; EC 3.6.4.12 P25206 17215 1|1 A4 mouse S112-p 2840507 SFGSKHVsPRTLTSC MCM_OB molecular association, regulation cell cycle regulation MCM2(INDUCES); MCM7(INDUCES); MCM5(INDUCES) DNA(INDUCES) 18524952 3 0 0 +HTR3A 5-HT(3) Channel, cation; Channel, ligand-gated; Membrane protein, integral; Membrane protein, multi-pass; Transporter, ion channel P46098 3359 11q23.2 human T369-p 28712602 TSQRPPAtSQATKTD Neur_chan_memb receptor desensitization, inhibited 23740249 1 0 0 +Nr1h3 LXR-alpha DNA-binding; Motility/polarity/chemotaxis; Nuclear receptor Q9Z0Y9 22259 2 E1|2 50.52 cM mouse T290-p 479433 DQIALLKtSAIEVML Hormone_recep molecular association, regulation; activity, inhibited transcription, inhibited; signaling pathway regulation SRC-1(DISRUPTS); N-CoR1(INDUCES); RXRA(DISRUPTS) 17296605 1 0 0 DNA Binding Activity of LXR/ RXR heterodimer was decreased. +Prkab1 AMPKB1 Autophagy; KINASE; Protein kinase, regulatory subunit P80386 83803 12q16 rat S108-p 448522 SKLPLTRsQNNFVAI AMPK1_CBM enzymatic activity, inhibited 11171104 11 64 2 +Foxo3 FOXO3A Autophagy; DNA-binding; Oncoprotein; Transcription factor Q9WVH4 56484 10 B2|10 22.79 cM mouse S317-p 453423 SRTNSNAsTVSGRLS intracellular localization cell cycle regulation; transcription, inhibited 12857750; 33530926 11 0 1 +NR1H3 LXR-alpha DNA-binding; Motility/polarity/chemotaxis; Nuclear receptor Q13133 10062 11p11.2 human S198-p 469114 SLPPRASsPPQILPQ protein conformation cell motility, inhibited; transcription, inhibited; transcription, altered 18250151; 25825525 6 0 0 CCR7, MARCKS, repression of pro-inflammatory genes; inhibits CCL24 expression +Espl1 separase EC 3.4.22.49; Protease P60330 105988 15|15 F3 mouse T1341-p 447675 EEEGPPCtPKPPGRA molecular association, regulation cytoskeletal reorganization 23857768 3 3 0 S1120 T1341 AA mutant -fewer cold-stable kinetochore-microtubule attachments and lacks tension +Tfap2a AP-2 alpha DNA-binding; Transcription factor P34056 21418 13 A3.3|13 20.01 cM mouse S258-p 5024712 GVLRRAKsKNGGRSL TF_AP-2 molecular association, regulation transcription, inhibited DNA(INDUCES) 21345437 2 0 0 induces adiponectin DNA binding thus controlling its transcription +Myl12b MRLC2 Contractile P18666 50685 9q38 rat S20-p 448595 KRPQRATsNVFAMFD activity, induced; intracellular localization; protein conformation exocytosis, altered 18283106; 24414065; 9425160 62 64 295 +GTF2I GTF2I iso2 DNA-binding; Transcription, coactivator/corepressor P78347-2 2969 7q11.23 human S371-p 457074 GIPFRRPsTYGIPRL GTF2I molecular association, regulation transcription, altered SMAD3(INDUCES) 16055503 2 11 139 +Pln PLB Inhibitor; Membrane protein, integral P61016 64672 20q11 rat S16-p 448114 RSAIRRAsTIEMPQQ Phospholamban activity, induced; enzymatic activity, induced 21447388; 33624728; 33798601 78 15 66 induces SERCA activity; induced SERCA2a activity; induce calcium uptake +MISP MISP Unknown function Q8IVT2 126353 19p13.3 human S541-p 3205368 PALRLQKsQSSDLLE AKAP2_C molecular association, regulation ACTA1(DISRUPTS) 34023777 1 13 19 +FOXP3 FOXP3 C2H2-type zinc finger protein; Cell cycle regulation; DNA-binding; Transcription factor Q9BZS1 50943 Xp11.23 human S422-p 35517300 KKRSQRPsRCSNPTP molecular association, regulation transcription, inhibited DNA(DISRUPTS) 25096571 1 0 0 +PRKCE PKCE EC 2.7.11.13; KINASE; Kinase, protein; Protein kinase, AGC; Protein kinase, Ser/Thr (non-receptor) Q02156 5581 2p21 human T566-p 448787 LNGVTTTtFCGTPDY Pkinase molecular association, regulation; intracellular localization; enzymatic activity, induced cell growth, induced AKAP9(DISRUPTS) 10945988; 11964154; 21806543 6 2 0 +SCN5A SCN5A Channel, sodium; Membrane protein, integral; Membrane protein, multi-pass Q14524 6331 3p22.2 human S664-p 27281501 GARQRALsAVSVLTS Na_trans_cytopl activity, induced; protein conformation 33410863 4 6 0 +FGF2 FGF2 Activator; Motility/polarity/chemotaxis P09038 2247 4q28.1 human S250-p 3146601 NNYNTYRsRKYTSWY FGF molecular association, regulation cell differentiation, altered; cell growth, altered CK2B(INDUCES) 10657989 1 0 0 +Dppa2 DPPA2 Cancer Testis Antigen (CTA) Q9CWH0 73703 16|16 B5 mouse K31-sm 1877126901 ILTLVPFkEEEEPNT sumoylation transcription, inhibited 31226106; 32937131 2 2 0 +FGFR4 FGFR4 EC 2.7.10.1; KINASE; Kinase, protein; Membrane protein, integral; Protein kinase, TK; Protein kinase, tyrosine (receptor) P22455 2264 5q35.2 human Y390-p 52421900 LLLLAGLyRGQALHG TM molecular association, regulation STAT3(INDUCES) 26675719 1 1 0 +Th TH Amino Acid Metabolism - tyrosine; EC 1.14.16.2; Endoplasmic reticulum; Mitochondrial; Oxidoreductase; Vesicle P24529 21823 7 F5|7 88.06 cM mouse S31-p 448544 KQAEAVTsPRFIGRR TOH_N protein stabilization; enzymatic activity, induced neural plasticity 15471880; 32358047 43 8 0 IRL790-induced neurotransmission +Ulk1 ULK1 Autophagy; EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, Other; Protein kinase, Ser/Thr (non-receptor) O70405 22241 5|5 F mouse S757-p 483139 PVVFTVGsPPSGATP molecular association, regulation; enzymatic activity, inhibited autophagy, induced; autophagy, inhibited; transcription, altered ATG13(DISRUPTS); AMPKA1(DISRUPTS) 21258367; 25361081; 29196462; 32912901; 33528041; 34695513; 34749750; 35805144; 36099296 78 15 2 +Camk2a CAMK2A EC 2.7.11.17; KINASE; Kinase, protein; Protein kinase, CAMK; Protein kinase, Ser/Thr (non-receptor) P11275 25400 18q12.1 rat T286-p 447797 SCMHRQEtVDCLKKF molecular association, regulation; intracellular localization; protein conformation; phosphorylation; enzymatic activity, induced neural plasticity; cell growth, induced; cytoskeletal reorganization; signaling pathway regulation DRD3(INDUCES); RPT6(INDUCES); NMDAR2A(INDUCES); CAMK2A(INDUCES); NMDAR2B(INDUCES); CAMK2B(INDUCES); SYN1(INDUCES); Calmodulin(INDUCES); CAMK2A(DISRUPTS); MARCKS(INDUCES) 15383398; 15447676; 15788767; 16049173; 16095822; 17144902; 17156196; 17559813; 19217379; 20178748; 20660727; 21059908; 23467346; 23490331; 24407174; 9681448; 9774470 155 34 72 +WTAP WTAP Nucleolus; Spliceosome Q15007 9589 6q25.3 human S341-p 3196721 AGYESVDsPTGSENS protein stabilization carcinogenesis, induced; cell differentiation, induced 33217317; 34312368 2 6 0 +FOXA1 FOXA1 DNA-binding; Transcription factor P55317 3169 14q21.1 human K270-ac 11263049 QKRFKCEkQPGAGGG molecular association, regulation chromatin organization, altered DNA(DISRUPTS) 19897491 1 0 0 +GJA1 GJA1 Channel, misc.; Membrane protein, integral; Membrane protein, multi-pass; Motility/polarity/chemotaxis P17302 2697 6q22.31 human Y265-p 447815 KDCGSQKyAYFNGCS molecular association, regulation; intracellular localization; protein processing; activity, inhibited; protein conformation; phosphorylation signaling pathway regulation Src(INDUCES); ZO1(INDUCES); DBN1(DISRUPTS) 11035005; 23828237; 26033246; 30448479 26 3 11 inhibits pregnancy-adapted Ca2+ response; induces phosphorylation of Y313 and Y247 +RBL1 Rb-like 1 Transcription, coactivator/corepressor; Tumor suppressor P28749 5933 20q11.23 human T997-p 3903587 HKNGSGLtPRSALLY Rb_C molecular association, regulation E2F1(DISRUPTS) 28439018 1 4 16 +PRMT5 PRMT5 Cell cycle regulation; EC 2.1.1.125; METHYLTRANSFERASE; Methyltransferase; Methyltransferase, protein arginine; RNA processing O14744 10419 14q11.2 human S335-p 1869601001 EKDPIKYsQYQQAIY PRMT5 molecular association, regulation; methylation; intracellular localization; enzymatic activity, induced cell growth, induced; apoptosis, inhibited; signaling pathway regulation NDRG2(INDUCES) 31765670 1 1 0 +CIITA CIITA DNA-binding; EC 2.7.11.1; KINASE; Protein kinase, Ser/Thr (non-receptor); Transcription, coactivator/corepressor P33076 4261 16p13.13 human S1050-p 448442 AASLLRLsLYNNCIC LRR_6 transcription, altered 11416140 1 0 0 +CEP76 CEP76 Q8TAP6 79959 18p11.21 human K279-ac 14320646 ERQKTAEkERLFLVY activity, inhibited; phosphorylation 27065328 1 2 0 acetylation at K279 limits protein activity and S83 phosphorylation +Per2 PER2 Nuclear receptor co-regulator; Nucleolus; Transcription factor O54943 18627 1|1 D mouse S53-p 9439800 TGRDSQGsDCDDNGK protein degradation transcription, altered 19491384 1 0 0 ; S53A mutant of Per2 impairs circadian gene expression +Pax6 PAX6 DNA-binding; Motility/polarity/chemotaxis; Transcription factor P63015 18508 2 E3|2 55.31 cM mouse T373-p 458810 GRSYDTYtPPHMQTH transcription, induced 16407227 1 0 1 +Mef2d MEF2D DNA-binding; Transcription factor O89038 81518 2q34 rat S430-p 449407 SIKSEPVsPSRERSP protein degradation apoptosis, induced 12691662; 25417143 7 19 26 +Rem1 REM1 G protein; G protein, monomeric; G protein, monomeric, RGK O35929 19700 2|2 H1 mouse S288-p 1211203 RRALKARsKSCHNLA molecular association, regulation; intracellular localization 14-3-3 beta(DISRUPTS) 17605760 1 0 0 +RELA NFkB-p65 DNA-binding; Nuclear receptor co-regulator; Transcription factor Q04206 5970 11q13.1 human K315-ub 25087013 TFKSIMKkSPFSGPT transcription, inhibited 21706061 1 2 0 inhibits acetylation +Kcnma1 KCNMA1 iso5 Channel, potassium; Endoplasmic reticulum; Membrane protein, integral; Membrane protein, multi-pass Q08460-5 16531 14|14 A3 mouse S873-p 469989 HGMLRQPsITTGVNI activity, induced 23407708 4 2 0 regulates NO/cGMP signaling +EIF4ENIF1 4E-T Karyopherin; Nuclear import; Translation Q9NRA8 56478 22q12.2 human S513-p 3213594 NLESHLMsPAEIPGQ EIF4E-T molecular association, regulation 4E-T(INDUCES) 22966201 1 10 2 required for processing bodies (PBs or P bodies) assembly +Becn1 beclin 1 Adaptor/scaffold; Autophagy; Membrane protein, peripheral O88597 56208 11|11 D mouse S91-p 5473540 ARMMSTEsANSFTLI autophagy, induced 33779513 14 2 1 +MAPT Tau iso8 ACETYLTRANSFERASE; Acetyltransferase; Cytoskeletal P10636-8 4137 17q21.31 human K163-ac 56833100 GAAPPGQkGQANATR phosphorylation 28855586 2 0 0 inhibts Tau iso8 phosphorylation and microtubule binding, ameliorates amyloid-beta toxicity +RGS4 RGS4 GAP; GAP, RGS Q0R4E4 100009014 rabbit S103-p 31033000 EEYKKIKsPSKLSPK RGS molecular association, regulation G-alpha(q)(INDUCES) 24407588 1 1 0 +RUNX1/RUNX1T1 fusion AML1-ETO A0A7S8LV65 human K58-m1 1880752700 AGAALAGkLRSGDRS carcinogenesis, induced; cell growth, induced; transcription, inhibited 31699991 1 1 0 essential for leukemic cell expansion +Npr2 ANPB EC 4.6.1.2; Guanylyl cyclase; KINASE; Kinase, protein; Lyase; Membrane protein, integral; Nucleotide Metabolism - purine; Protein kinase, RGC; Protein kinase, dual-specificity (receptor); Receptor, misc. P16067 116564 5q22 rat S523-p 447761 TLSLRGSsYGSLMTA PK_Tyr_Ser-Thr activity, induced 9624142 3 3 0 +XPC XPC DNA repair, damage Q01831 7508 3p25.1 human K655-sm 2798303 ALKRHLLkYEAIYPE BHD_1 protein degradation DNA repair, induced 17693435 1 0 0 +NUB1 NYREN18 Ubiquitin conjugating system Q9Y5A7 51667 7q36.1 human K159-ub 12288848 KAMVLELkQSEEDAR Ubiquitin_5 neddylation 28099510 1 3 1 inhibits neddylation, modulates NYREN18 K159 ubiquitination +Net1 NET1 GEF; GEF, Rac/Rho; Motility/polarity/chemotaxis; Oncoprotein A0A8I6AVA8 307098 10p15.1 rat S106-p 3204291 TSLANLIsPVRNGAV intracellular localization cell motility, induced; cytoskeletal reorganization 29361525 2 11 0 relocalization to cytosol; increase in invadopodia number and degradation area +Jak2 JAK2 EC 2.7.10.2; KINASE; Kinase, protein; Oncoprotein; Protein kinase, TK; Protein kinase, tyrosine (non-receptor) Q62120 16452 19 C1|19 23.73 cM mouse Y972-p 470145 EYLGTKRyIHRDLAT PK_Tyr_Ser-Thr protein conformation; phosphorylation; enzymatic activity, induced 18636744; 20304997 3 1 0 +ITGB4 ITGB4 iso2 Cell adhesion; Membrane protein, integral; Motility/polarity/chemotaxis; Receptor, misc. P16144-2 3691 17q25.1 human Y1422-p 450140 SSTLTRDyNSLTRSE molecular association, regulation cell adhesion, altered PLCG1(INDUCES); SHC1(INDUCES) 11044453; 33883672 3 0 72 +FBP1 FBPase Carbohydrate Metabolism - fructose and mannose; Carbohydrate Metabolism - glycolysis and gluconeogenesis; Carbohydrate Metabolism - pentose phosphate pathway; EC 3.1.3.11; Mitochondrial; Phosphatase (non-protein) P09467 2203 9q22.32 human S88-p 55578725 LVMNMLKsSFATCVL FBPase enzymatic activity, inhibited 27153534 1 1 0 +PTH1R PTHR GPCR, family 2; Membrane protein, integral; Membrane protein, multi-pass; Receptor, GPCR Q03431 5745 3p21.31 human S504-p 2853101 GPMVSHTsVTNVGPR receptor internalization, induced; molecular association, regulation ARR3(INDUCES) 27623777 3 1 0 S503 AND T504 IN THE SECOND CLUSTER ARE RESPONSIBLE FOR 70% OF ARRESTIN3 RECRUITMENT +Irf3 IRF3 DNA-binding; Transcription factor P70671 54131 7|7 B3 mouse K359-ac 1880015200 VKRLVMVkVVPTCLK intracellular localization transcription, inhibited 30842237 1 1 0 KAT8 impaired recruitment of IRF3 to Ifn gene promoters +CCNE2 CCNE2 Activator; Cell cycle regulation O96020 9134 8q22.1 human T392-p 452067 VCNGGIMtPPKSTEK protein degradation; ubiquitination 19084516; 9840943 2 8 6 +LMO7 LMO7 iso3 Adaptor/scaffold Q8WWI1-3 4008 13q22.2 human S417-p 4687531 KWKDRRKsYTSDLQK DUF4757 molecular association, regulation; phosphorylation carcinogenesis, inhibited; cell growth, inhibited; transcription, induced; signaling pathway regulation STING(INDUCES) 33767426 2 16 14 binding to STING induces STING-TBK1 binding and TBK1 autophosphorylation, regulates STING?IFN-? pathway +Sqstm1 SQSTM1 Autophagy; Nuclear receptor co-regulator; Ubiquitin conjugating system O08623 113894 10q22 rat S402-p 22264800 ESLSQMLsMGFSDEG UBA_5 molecular association, regulation autophagy, induced; autophagy, altered LRRK2(INDUCES) 27631370; 34026282 30 7 0 +PIK3R2 PIK3R2 Kinase, lipid; Motility/polarity/chemotaxis O00459 5296 19p13.11 human Y464-p 449572 SREYDQLyEEYTRTS PI3K_P85_iSH2 activity, induced; molecular association, regulation; intracellular localization; phosphorylation cell cycle regulation; carcinogenesis, induced; carcinogenesis, inhibited; cell growth, induced; cell motility, induced; transcription, altered; signaling pathway regulation KPNA1(INDUCES) 24634221; 26411363; 34380633; 34785213; 36857183 10 55 1664 +Pacsin2 PACSIN2 Adaptor/scaffold; Motility/polarity/chemotaxis Q9WVE8 23970 15|15 E1 mouse S313-p 4786393 ADLNRTLsRREKKKA intracellular localization 26092940 3 7 20 membrane binding affinity and tubulation decreased +Trhr TRHR GPCR, family 1; Membrane protein, integral; Membrane protein, multi-pass; Receptor, GPCR Q01717 25570 7q31 rat S364-p 1229700 IKESDRFsTELDDIT receptor internalization, altered 17989235; 20345371 3 0 0 +Gpm6a GPM6A Cell surface; Channel, calcium; Membrane protein, integral; Membrane protein, multi-pass Q812E9 306439 16p11 rat T10-p 11488702 ENMEEGQtQKGCFEC activity, induced 12359212 1 0 0 +KIT Kit EC 2.7.10.1; KINASE; Kinase, protein; Membrane protein, integral; Oncoprotein; Protein kinase, TK; Protein kinase, tyrosine (receptor) P10721 3815 4q12 human Y553-p 13876401 KYLQKPMyEVQWKVV enzymatic activity, induced 20147452 1 1 0 +CDCP1 CDCP1 Cell surface; Membrane protein, integral Q9H5V8 64866 3p21.31 human Y806-p 454988 PESESEPyTFSHPNN carcinogenesis, induced; cell growth, induced 25728678 2 6 93 Tyr734 is a key precursor phosphorylation event allowing Tyr707 and Tyr806 phosphorylation +LZTS2 LZTS2 Nuclear export Q9BRK4 84445 10q24.31 human S224-p 1871717502 LSDSGRNsLSSLPTY protein degradation; molecular association, regulation; ubiquitination; phosphorylation carcinogenesis, induced; cell motility, induced; cell growth, induced; signaling pathway regulation BTRC(INDUCES) 33420362 1 0 0 induces phosphorylation of downstream targets thus inducing the PI3K/AKT signaling pathway +UHRF1 UHRF1 iso2 DNA-binding; EC 6.3.2.-; EC 6.3.2.19; Ligase; Transcription factor; UBIQUITIN LIGASE; Ubiquitin conjugating system; Ubiquitin ligase Q96T88-2 29128 19p13.3 human S311-p 2902206 DNPMRRKsGPSCKHC protein degradation 28394343 3 1 0 +Gab2 GAB2 Adaptor/scaffold Q9Z1S8 14389 7|7 E1 mouse T388-p 448383 ATIPRRNtLPAMDNS signaling pathway regulation 26060331 2 23 54 enhances insulin-induced Akt signaling; suppresses EGF-induced Akt signaling +Cdk8 CDK8 Cell cycle regulation; EC 2.7.11.22; EC 2.7.11.23; KINASE; Kinase, protein; Protein kinase, CMGC; Protein kinase, Ser/Thr (non-receptor) Q8R3L8 264064 5|5 G3 mouse S62-p 1876860402 EGTGISMsACREIAL Pkinase phosphorylation cell growth, inhibited; transcription, induced 35394840 1 1 0 +YAP1 YAP1 Oncoprotein; Transcription, coactivator/corepressor P46937 10413 11q22.1 human S397-p 3190672 TYHSRDEsTDSGLSM protein degradation; ubiquitination; intracellular localization cell differentiation, inhibited; carcinogenesis, induced; carcinogenesis, inhibited; cell growth, inhibited; apoptosis, induced; transcription, induced; cell growth, induced; cell motility, altered; transcription, inhibited 24658687; 26039999; 27593935; 31239271; 33536280; 34052254 32 13 5 +CHN2 ARHGAP3 GAP; GAP, Rac/Rho P52757 1124 7p14.3 human Y21-p 482808 VSSDAEEyQPPIWKS activity, inhibited cell motility, altered 17560670 1 0 0 negatively controls Rac-GAP activity +XRCC5 Ku80 DNA-binding; EC 3.6.1.-; EC 3.6.4.-; Helicase; Nuclear receptor co-regulator; Nucleolus; RNA-binding P13010 7520 2q35 human K439-ub 15391484 QYMFSSLkNSKKYAP Ku molecular association, regulation DNA repair, induced DNA(DISRUPTS) 27895153 1 2 1 +Pip4p1 TMEM55B EC 3.1.3.78; Hydrolase; Membrane protein, integral; Membrane protein, multi-pass Q3TWL2 219024 14|14 C1 mouse S169-p 3204510 PVHPGPLsPEPQPMG Tmemb_55A intracellular localization 31329883 1 27 13 +MAML1 MAML1 Transcription, coactivator/corepressor Q92585 9794 5q35.3 human K299-sm 13310801 LAQDINIkTEFSPAA molecular association, regulation transcription, inhibited HDAC7(INDUCES) 20203086 1 1 0 +SUFU SUFU Adaptor/scaffold; Transcription, coactivator/corepressor; Tumor suppressor Q9UMX1 51684 10q24.32 human S342-p 4786843 LAHDRAPsRKDSLES SUFU_C molecular association, regulation; protein stabilization; intracellular localization FBXL17(DISRUPTS) 21317289; 27234298 4 13 0 +Agtr1 AT1 GPCR, family 1; Membrane protein, integral; Membrane protein, multi-pass; Receptor, GPCR P25095 24180 17p12 rat S331-p 452091 AKSHSSLsTKMSTLS activity, induced 16831865 2 1 0 +KLF11 TIEG2 C2H2-type zinc finger protein; DNA-binding; Transcription factor O14901 8462 2p25.1 human S124-p 456010 PSTRTPVsPQVTDSK molecular association, regulation SIN3A(DISRUPTS) 12006497 1 5 22 +Npas4 NPAS4 DNA-binding Q8BGD7 225872 19|19 A mouse S580-p 1871095702 KLPPSPSsPGNGDCT molecular association, regulation neural plasticity; transcription, induced CBP(INDUCES) 31801086 1 1 0 +TH TH iso2 Amino Acid Metabolism - tyrosine; EC 1.14.16.2; Endoplasmic reticulum; Mitochondrial; Oxidoreductase; Vesicle P07101-2 7054 11p15.5 human S58-p 448544 SYTPTPRsPRFIGRR TOH_N enzymatic activity, induced 7901013 43 8 0 +NR3C2 MCR DNA-binding; Nuclear receptor P08235 4306 4q31.23 human S843-p 29669801 NEEKMHQsAMYELCQ Hormone_recep intracellular localization transcription, induced; transcription, inhibited 24206662; 30021155 3 2 0 pendrin expression; nuclear (WT and S843A) vs cytoplasmic (S843E) localization +Mybl2 B-Myb DNA-binding; Motility/polarity/chemotaxis; Transcription factor P48972 17865 2 H2|2 84.0 cM mouse T524-p 450112 DNTPHTPtPFKNALE Cmyb_C activity, induced transcription, induced 10095772 3 1 9 +BMI1 BMI1 EC 6.3.2.-; Ligase; Motility/polarity/chemotaxis; Oncoprotein; UBIQUITIN LIGASE; Ubiquitin conjugating system; Ubiquitin ligase P35226 648 10p12.2 human S110-p 56654163 SADAANGsNEDRGEV protein degradation cell growth, induced 28270146 1 2 0 +Hck Hck EC 2.7.10.2; KINASE; Kinase, protein; Oncoprotein; Protein kinase, TK; Protein kinase, tyrosine (non-receptor) P08103 15162 2 H1|2 75.41 cM mouse Y520-p 448322 YTATESQyQQQP___ enzymatic activity, inhibited 10934191 3 8 326 Y519 phosphorylation keeps the kinase in an inactive state and does not permit autophosphorylation at Y49 and Y408. +LDB1 LDB1 iso2 Transcription, coactivator/corepressor Q86U70-2 8861 10q24.32 human K134-ub 14512104 SMVTQHGkPMFTQVC LIM_bind protein degradation 32229578 2 0 0 +YBX1 YB-1 RNA processing; RNA splicing; RNA-binding; Transcription factor P67809 4904 1p34.2 human Y281-p 29656300 QQPPQRRyRRNFNYR intracellular localization 24103640 1 0 0 Y281 phosphorylation nuclear localization, unphosphorylated cytoplasmic localization +Eif4ebp1 4E-BP1 Translation; Translation initiation Q60876 13685 8 A2|8 15.95 cM mouse S64-p 447527 FLMECRNsPVAKTPP eIF_4EBP transcription, induced; translation, induced 34664403; 34704268 104 60 6 +Rasgrp2 RASGRP2 GEF; GEF, Ras Q9QUG9 19395 19|19 A mouse S117-p 468585 EGNRRHSsLIDIESV activity, induced; molecular association, regulation 14-3-3 beta(INDUCES) 26804993 2 14 12 +TPD52 TPD52 Calcium-binding; Endoplasmic reticulum P55327 7163 8q21.13 human S176-p 465974 KNSPTFKsFEEKVEN TPD52 activity, induced; molecular association, regulation; intracellular localization cell cycle regulation; exocytosis, induced LAMP1(INDUCES) 20032513; 20946871; 23868405 4 56 31 +TGFBR1 TGFBR1 EC 2.7.11.30; KINASE; Kinase, protein; Membrane protein, integral; Protein kinase, Ser/Thr (receptor); Protein kinase, TKL; Receptor, misc. P36897 7046 9q22.33 human T176-p 4331007 PFISEGTtLKDLIYD TGF_beta_GS cell growth, altered 8576253 1 0 0 +Tsc2 TSC2 Cell cycle regulation; GAP; GAP, misc.; Nuclear receptor co-regulator; Tumor suppressor P49816 24855 10q12 rat S1385-p 450216 FQPSQPLsKSSSSPE activity, inhibited; phosphorylation translation, altered; apoptosis, inhibited 16959574 2 1 1 inhibits mTOR signaling. required for Wnt-3a to stimulation phosphorylation of S6K and 4EBP1 and increase protein levels of cyclin D1 and VEGF (cyclin D1 through translation not transcription). +Kif21a KIF21A Microtubule-binding; Motor Q9QXL2 16564 15 E3|15 45.86 cM mouse T1159-p 487343 KNKARRRtTTQMELL molecular association, regulation ANKRD15(DISRUPTS) 29158259 1 1 10 +Nsmf NSMF Adaptor/scaffold Q9EPI6 117536 3p13 rat S180-p 27713502 AKLVPGPsPRAFGLE activity, induced; molecular association, regulation; intracellular localization; phosphorylation apoptosis, inhibited; transcription, induced LMO4(DISRUPTS) 23452857; 27559307; 36594364 3 1 0 +PRKCA PKCA EC 2.7.11.13; KINASE; Kinase, protein; Oncoprotein; Protein kinase, AGC; Protein kinase, Ser/Thr (non-receptor) P17252 5578 17q24.2 human T638-p 448685 TRGQPVLtPPDQLVI Pkinase_C molecular association, regulation; intracellular localization; phosphorylation; enzymatic activity, induced cell cycle regulation CD82(INDUCES) 17504762; 17942932 22 15 2 phosphorylation of PKCA induces phosphorylation of EGFR; Requires dual phosphorylation to locate to pericentrion. +Srpk2 SRPK2 EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, CMGC; Protein kinase, Ser/Thr (non-receptor) NP_001100045 296753 4q11 rat T485-p 483237 PSRDRSRtVSASSTG apoptosis, altered 19592491 3 6 0 +PAPOLA PAP-alpha EC 2.7.7.19; RNA processing; RNA splicing; Transferase P51003 10914 14q32.2 human K444-sm 2586344 WVIGLVFkKTENSEN protein stabilization; enzymatic activity, inhibited 18281463 1 0 0 +KLF13 KLF13 C2H2-type zinc finger protein; DNA-binding Q9Y2Y9 51621 15q13.3 human S119-p 40721820 GAAAAPPsPAWSEPE protein degradation; ubiquitination 37029927 1 1 0 +FAF1 FAF1 Apoptosis; Nuclear receptor co-regulator Q9UNN5 11124 1p32.3 human S289-p 450286 ITDVHMVsDSDGDDF intracellular localization cell cycle regulation 12832043; 18790738; 27662363 3 2 0 mediates the proteasome-dependent degradation of AurA; nuclear localization; induces G2/M arrest +SLC9A1 NHE1 Membrane protein, integral; Membrane protein, multi-pass; Motility/polarity/chemotaxis; Transporter; Transporter, SLC family P19634 6548 1p36.11 human S703-p 448347 MSRARIGsDPLAYEP activity, induced cell growth, induced; cell motility, induced; cytoskeletal reorganization; transcription, altered; cell growth, altered 10400637; 25578862; 27049728 9 73 199 stress fiber formation, in S703A and T653A mutants proliferation was substantially higher; migration, invasion, spheroid growth, anchorage-dependent and soft agar colony formation +Vim Vimentin Cytoskeletal; Motility/polarity/chemotaxis P20152 22352 2 A1|2 10.04 cM mouse S73-p 449025 SAVRLRSsVPGVRLL Filament_head intracellular localization cytoskeletal reorganization 12458200; 35656400 14 53 32 +Hrh1 H1R GPCR, family 1; Membrane protein, integral; Membrane protein, multi-pass; Receptor, GPCR P70174 15465 6 E3|6 53.05 cM mouse S399-p 450937 WKRLRSHsRQYVSGL 7tm_1 receptor desensitization, induced; activity, inhibited 24709960 4 0 0 greater Mn2+ influx, reduced production of intracellular DAG +PRDX2 PRDX2 EC 1.11.1.15; Oxidoreductase P32119 7001 19p13.13 human Y193-p 448985 NVDDSKEyFSKHN__ 1-cysPrx_C intracellular localization; protein conformation; enzymatic activity, induced 33535382 1 8 119 +EGFR EGFR EC 2.7.10.1; KINASE; Kinase, protein; Membrane protein, integral; Oncoprotein; Protein kinase, TK; Protein kinase, tyrosine (receptor) P00533 1956 7p11.2 human S229-p 18944906 RCRGKSPsDCCHNQC Furin-like intracellular localization transcription, induced 21487020 1 1 0 develop gefitinib resistance; regulates expression of BCRP/ABCG2 +KNL1 CASC5 iso2 Cancer Testis Antigen (CTA); Cell cycle regulation Q8NG31-2 57082 15q15.1 human T875-p 40560200 DKNDMDItKSYTIEI MELT molecular association, regulation; intracellular localization cell cycle regulation BUB3(INDUCES) 24363448; 26119734 2 0 0 induces localization of BUB1 and BUBR1 ; recruitment of SAC proteins +Cd79a Ig-alpha Immunoglobulin superfamily; Membrane protein, integral P11911 12518 7 A3|7 13.49 cM mouse Y182-p 473649 DYEDENLyEGLNLDD ITAM activity, induced; molecular association, regulation; phosphorylation cell differentiation, altered; signaling pathway regulation Syk(INDUCES) 11859098; 11909947; 17163454; 9531288 8 1 13 Ca(2+) signaling +Ptk2 FAK EC 2.7.10.2; KINASE; Kinase, protein; Protein kinase, TK; Protein kinase, tyrosine (non-receptor) P34152 14083 15 D3|15 33.94 cM mouse Y576-p 447889 RYMEDSTyYKASKGK PK_Tyr_Ser-Thr activity, induced; molecular association, regulation carcinogenesis, induced; cell growth, induced; cell adhesion, altered; transcription, altered; signaling pathway regulation P130Cas(INDUCES) 10672902; 36209205; 7529876; 9038154 95 65 2523 +TBC1D3 TBC1D3 GAP; GAP, Rab; Oncoprotein Q8IZP1 729873 17q12 human Y163-p 64210900 HIFFRDRyGTKQREL RabGAP-TBC molecular association, regulation Calmodulin(NOT_REPORTED) 28422741 1 0 0 +BCL10 Bcl-10 Apoptosis; Transcription, coactivator/corepressor; Tumor suppressor O95999 8915 1p22.3 human K63-ub 2134712 SCRTSSRkRAGKLLD CARD activity, induced; protein degradation; molecular association, regulation; intracellular localization carcinogenesis, induced; transcription, induced; signaling pathway regulation IKKG(INDUCES) 18287044; 27070702; 27777308 3 0 0 promote NF-kB activation, cIAP1/2-mediated polyubiquitination is necessary for the recruitment of LUBAC to the CBM complex; TCR-mediated NF-?B activation +STK38 NDR1 EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, AGC; Protein kinase, Ser/Thr (non-receptor) Q15208 11329 6p21.31 human T407-p 41425401 EIKSIDDtSNFDEFP Pkinase_C molecular association, regulation; intracellular localization; enzymatic activity, inhibited; protein conformation cell cycle regulation; cytoskeletal reorganization MOB1A(DISRUPTS); HCCA2(INDUCES) 26057687 1 0 0 regulation of spindle orientation, cortical localization of LGN-NuMA +DNM1L DRP1 Apoptosis; EC 3.6.5.5; Endoplasmic reticulum; Hydrolase; Microtubule-binding; Mitochondrial; Motor O00429 10059 12p11.21 human S40-p 31872528 TQSSGKSsVLESLVG Dynamin_N intracellular localization; enzymatic activity, induced apoptosis, induced 25192600 2 1 0 mitochondrial localization, increased GTPase activity, mitochondrial fragmentation +Sod2 SOD2 EC 1.15.1.1; Mitochondrial; Oxidoreductase P09671 20656 17 A1|17 8.75 cM mouse K114-ac 480880 PKGGGEPkGELLEAI Sod_Fe_C enzymatic activity, altered 28433661 0 5 8 +STT3A Chk1 EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, CAMK; Protein kinase, Ser/Thr (non-receptor); Tumor suppressor Q8AYC9 374260 chicken S286-p 465527 SSGGVTEsPGALPKH enzymatic activity, induced cell cycle regulation 21765472 5 12 14 +MITF MITF iso9 DNA-binding; Oncoprotein; Transcription factor O75030-9 4286 3p13 human S73-p 450264 PGSSAPNsPMAMLTL MITF_TFEB_C_3_N activity, induced; protein degradation; ubiquitination cell cycle regulation; transcription, induced; transcription, altered 10673502; 16162175; 20701798; 21749389 16 1 0 enhances cell survival +GFAP GFAP Cytoskeletal P14136 2670 17q21.31 human S38-p 449621 LGPGTRLsLARMPPP Filament_head protein stabilization 12177195 6 3 0 +Gorasp1 GRASP65 Vesicle O35254 56082 8q32 rat S376-p 467957 FEISFPDsPGSQAQV intracellular localization cell cycle regulation 23259055 1 13 9 Regulation of mitotic golgi disassembly and reassembly; inactivation of T220/T224, and eventually S277partial dephosphorylation +CD163L1 CD163L1 Membrane protein, integral; Receptor, misc. P30205 338056 cow Y1326-p 470034 DALAEAVyEELDYLL intracellular localization endocytosis, altered 16997376; 19130552 3 0 0 +IGF2BP1 IGF2BP1 RNA-binding; Translation Q9NZI8 10642 17q21.32 human K190-ub 15390840 VAAGAPAkQQQVDIP carcinogenesis, induced; cell growth, induced 34779401 1 5 9 hepatocarcinogenesis +SMAD3 SMAD3 DNA-binding; Nuclear receptor co-regulator; Transcription factor P84022 4088 15q22.33 human K53-m3 1883845003 GQLDELEkAITTQNV activity, induced; intracellular localization carcinogenesis, induced; cell motility, induced 35085106 1 1 0 targeting SMAD3 K53/K333 methylation inhibits cancer metastasis; membrane localization; promotes migration and invasion +CIB1 CIB1 Cell adhesion; Motility/polarity/chemotaxis Q99828 10519 15q26.1 human K65-ub 15386514 ILSLPELkANPFKER protein degradation cell motility, inhibited 33082516 1 6 3 +CDC20 CDC20 Cell cycle regulation; Ubiquitin conjugating system Q12834 991 1p34.2 human S170-p 23092094 KTCRYIPsLPDRILD protein degradation; molecular association, regulation; ubiquitination CDC27(INDUCES); CDH1(INDUCES) 23643811 1 0 1 +SHC1 SHC1 Adaptor/scaffold; Apoptosis; Mitochondrial; Motility/polarity/chemotaxis P29353 6464 1q21.3 human S54-p 457345 PPLPGDDsPTTLCSF protein stabilization apoptosis, induced 16251354 1 0 0 Phosphorylation necessary to promote activated-Rac1-induced oxidative stress (ROS-induced apoptosis). +Rps6ka3 RSK2 EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, AGC; Protein kinase, Ser/Thr (non-receptor) P18654 110651 X F4|X 73.27 cM mouse S369-p 448064 TAKTPKDsPGIPPSA Pkinase_C enzymatic activity, induced 10480933; 10856237 10 51 20 +Shc1 SHC1 Adaptor/scaffold; Apoptosis; Mitochondrial; Motility/polarity/chemotaxis P98083 20416 3 F1|3 39.11 cM mouse Y349-p 448509 EEPPDHQyYNDFPGK activity, induced; molecular association, regulation; phosphorylation cell differentiation, altered; cell growth, induced GRB2(INDUCES) 11713219; 12101399; 14576154; 15930121; 24837366 32 22 947 Shc3F breast tumor growth was significantly delayed, and display a significant increase in VEGF protein +Nfatc2 NFAT1 DNA-binding; Transcription factor Q60591 18019 2 H3|2 88.91 cM mouse S53-p 455325 PIAHKAIsSPSGLAY transcription, induced 11030334 0 7 2 +RET Ret EC 2.7.10.1; KINASE; Kinase, protein; Membrane protein, integral; Oncoprotein; Protein kinase, TK; Protein kinase, tyrosine (receptor) P07949 5979 10q11.21 human Y952-p 447628 VTLGGNPyPGIPPER PK_Tyr_Ser-Thr enzymatic activity, induced cell growth, altered 11956105; 8637703 2 0 0 +Csnk1d CK1D EC 2.7.11.1; EC 2.7.11.26; KINASE; Kinase, protein; Protein kinase, CK1; Protein kinase, Ser/Thr (non-receptor) Q06486 64462 10q32.3 rat S370-p 483997 MERERKVsMRLHRGA intracellular localization; enzymatic activity, inhibited 17594292; 23861943; 26803658 3 1 0 +TOP2A TOP2A EC 5.99.1.3; Isomerase P11388 7153 17q21.2 human T1343-p 448763 FSDFDEKtDDEDFVP intracellular localization 11699638 4 13 9 +MYLK smMLCK EC 2.7.11.18; KINASE; Kinase, protein; Protein kinase, CAMK; Protein kinase, Ser/Thr (non-receptor) P11799 396445 chicken S140-p 41411900 KTPGGRLsVPPVEHR molecular association, regulation ACTB(DISRUPTS) 26567572 2 1 0 in vitro the single S149D mutation reduced N27-157 association with F-actin +Oprk1 KOR-1 GPCR, family 1; Membrane protein, integral; Membrane protein, multi-pass; Receptor, GPCR P34975 29335 5q12 rat Y157-p 3082309 TMMSVDRyIAVCHPV 7tm_1 activity, induced 10995763 1 0 0 potentiation for KIR3 activation +USP2 USP2 DEUBIQUITINASE; EC 3.4.19.12; Protease; Ubiquitin-specific protease O75604 9099 11q23.3 human S2-p 1880716202 ______MsQLSSTLK molecular association, regulation DNA repair, induced RECQL4(INDUCES) DNA(INDUCES) 36436562 1 0 0 +BSG BSG iso2 Immunoglobulin superfamily; Membrane protein, integral P35613-2 682 19p13.3 human S252-p 476131 GSAPLKSsGQHQNDK molecular association, regulation; activity, inhibited; phosphorylation carcinogenesis, inhibited; cell growth, inhibited; cell growth, induced; cell motility, inhibited; transcription, induced; signaling pathway regulation SMAD4(INDUCES) 28684116; 31016558 2 11 0 inhibits Akt phosphorylation; decrease/inhibits STAT3 and Akt signaling +IL5RA IL5RA Membrane protein, integral; Receptor, cytokine Q01344 3568 3p26.2 human K379-ub 1883407601 FPPIPAPkSNIKDLF protein degradation cell differentiation, inhibited 35982175 1 0 0 translocation to and degradation in lysosomes, March2/3 negatively regulates eosinophil maturation, March2/3 de?ciency promotes eosinophilic airway in?ammation +PRKRA PACT Activator; RNA processing; RNA-binding O75569 8575 2q31.2 human S287-p 470038 PITVCHGsGISCGNA molecular association, regulation; enzymatic activity, induced apoptosis, altered; apoptosis, induced PACT(INDUCES); TRBP(DISRUPTS) 16982605; 21526770; 22473766; 26231208 4 0 0 PKR enzymatic activity induced; activates PKR +TTK TTK Cancer Testis Antigen (CTA); EC 2.7.12.1; KINASE; Kinase, protein; Protein kinase, Other; Protein kinase, dual-specificity (non-receptor) P33981 7272 6q14.1 human T33-p 2846502 KFKNEDLtDELSLNK enzymatic activity, inhibited; intracellular localization; enzymatic activity, induced cell cycle regulation 25265012; 26119734; 29502948; 36395767 9 24 12 autophosphorylation of this site is required for release TTK from kinetochore; causes decreased kinetochore localization of BubR1 and Mad2. +RBM17 RBM17 RNA splicing; RNA-binding; Spliceosome Q96I25 84991 10p15.1 human S222-p 3209223 EEQDRPRsPTGPSNS molecular association, regulation; phosphorylation RNA splicing, inhibited; RNA splicing, induced; cell motility, induced; cell growth, inhibited; transcription, inhibited; cell adhesion, inhibited RNA(DISRUPTS) 22615491; 23519612 2 41 0 induced cell invasion, enhanced Cortactin phosphorylation at ERK-dependent sites +ISX ISX DNA-binding Q2M1V0 91464 22q12.3 human S183-p 1874101900 RRLAPPTsCCPSAQD intracellular localization carcinogenesis, induced; cell motility, induced; cell growth, induced; transcription, induced 34265398 1 1 0 +SPRY2 SPRY2 Adaptor/scaffold; Inhibitor; Motility/polarity/chemotaxis O43597 10253 13q31.1 human Y269-p 3978701 FLPCLWCyLPAKGCL Sprouty activity, inhibited; phosphorylation transcription, altered 15637081 1 0 0 +Irf7 IRF7 DNA-binding; Transcription factor P70434 54123 7|7 F5 mouse S438-p 486438 SLGLCLSsTNSLYED transcription, induced DNA(INDUCES) 15743772; 33976210 2 0 0 +ITGB2 ITGB2 Cell adhesion; Cell surface; Membrane protein, integral; Motility/polarity/chemotaxis; Receptor, misc. P05107 3689 21q22.3 human T759-p 448535 PLFKSATtTVMNPKF Integrin_b_cyt molecular association, regulation kindlin-3(INDUCES) 23823319 2 0 0 +NEDD1 NEDD1 Cell cycle regulation Q8NHV4 121441 12q23.1 human S637-p 9379000 HSLLERYsVNEGLVA molecular association, regulation cell cycle regulation 19509060 2 1 0 important for binding of NEDD1 with gamma-tubulin +CDC25A CDC25A EC 3.1.3.48; Motility/polarity/chemotaxis; PHOSPHATASE; Protein phosphatase, dual-specificity P30304 993 3p21.31 human Y59-p 57761916 LQGLGSDyEQPLEVK molecular association, regulation PKM(INDUCES) 27485204 1 0 0 +Traf3ip2 TRAF3IP2 Apoptosis; UBIQUITIN LIGASE; Ubiquitin conjugating system; Ubiquitin ligase Q8N7N6 103213 10|10 B1 mouse S222-p 25687505 DLPGPLRsRELPPQF molecular association, regulation transcription, inhibited TRAF6(DISRUPTS) 22851696 1 0 0 +DDAH2 DDAH2 Apoptosis; EC 3.5.3.18; Hydrolase O95865 23564 6p21.33 human Y207-p 60179303 AVLTDHPyASLTLPD enzymatic activity, inhibited 27838434 1 0 0 +CASP9 CASP9 Apoptosis; EC 3.4.22.62; Protease P55211 842 1p36.21 human T125-p 449563 PEVLRPEtPRPVDIG activity, inhibited apoptosis, altered; apoptosis, induced 16287866; 17466630 7 4 10 inhibits apoptosis during mitosis +H3F3C H3 DNA-binding P84229 427887 chicken S28-p 455677 ATKAARKsAPATGGV Histone molecular association, regulation chromatin organization, altered; transcription, induced DNA(DISRUPTS) 17913747 50 18 0 +DUSP6 DUSP6 EC 3.1.3.16; EC 3.1.3.48; Motility/polarity/chemotaxis; PHOSPHATASE; Protein phosphatase, dual-specificity Q16828 1848 12q21.33 human S159-p 455265 DGSCSSSsPPLPVLG protein degradation 15632084 4 0 0 +TP53 p53 Activator; DNA-binding; Motility/polarity/chemotaxis; Nuclear receptor co-regulator; Transcription factor; Tumor suppressor P04637 7157 17p13.1 human K372-m1 2363903 HSSHLKSkKGQSTSR molecular association, regulation; protein stabilization; methylation; intracellular localization; protein conformation carcinogenesis, inhibited; cell growth, inhibited; apoptosis, induced; transcription, induced; transcription, altered DNA(INDUCES) 15525938; 17108971; 27270439; 27694900; 30881498; 31069954 7 0 0 +Prkch PKCH EC 2.7.11.13; KINASE; Kinase, protein; Protein kinase, AGC; Protein kinase, Ser/Thr (non-receptor) P23298 18755 12|12 C3 mouse S28-p 3074801 GLQPTRWsLRHSLFK C2 molecular association, regulation; intracellular localization cell growth, inhibited CTLA-4(INDUCES) 24705298 2 3 14 +Cdk6 CDK6 Cell cycle regulation; EC 2.7.11.22; KINASE; Kinase, protein; Protein kinase, CMGC; Protein kinase, Ser/Thr (non-receptor) Q64261 12571 5 A1|5 2.04 cM mouse D224-p 10359104 PLFRGSSdVDQLGKI Pkinase intracellular localization 19667758 1 0 0 +GCM1 GCM1 DNA-binding; Transcription factor Q9NP62 8521 6p12.1 human K156-sm 12004402 KGEHDHPkPETKLEA GCM molecular association, regulation transcription, inhibited DNA(DISRUPTS) 17646165 2 0 0 +UBA52-RPS27A-UBB-UBC ubiquitin Ubiquitin-like modifier P62988 2p16 human S20-p 14582508 ITLEVEPsDTIENVK ubiquitin enzymatic activity, induced 27425610 1 7 0 +DEF6 DEF6 GEF; GEF, Rac/Rho Q9H4E7 50619 6p21.31 human S597-p 4756642 SQGNRTPsPNSNEQQ activity, induced; molecular association, regulation transcription, induced IP3R1(INDUCES) 28993769 1 11 43 TCR stimulation-induced activation of NFAT, IL2, and IFNG, FasLG, CTLA4 and CD25 transcription +TK1 TK EC 2.7.1.21; KINASE; Kinase, other; Nucleotide Metabolism - pyrimidine; Xenobiotic Metabolism - drug metabolism - other enzymes P04183 7083 17q25.3 human S13-p 448816 LPTVLPGsPSKTRGQ protein degradation; molecular association, regulation; enzymatic activity, inhibited; enzymatic activity, induced TK(DISRUPTS) 12435275; 14697231; 25003822 4 15 1 TK phosphorylation-modulated [18F]FLT cellular retention; decreases tetramerization (increases dimer proportion) +APP APP Apoptosis; Cell surface; Membrane protein, integral; Receptor, misc.; Transcription factor P05067 351 21q21.3 human K724-ne 12124802 VITLVMLkKKQYTSI APP_amyloid transcription, inhibited Fe65(DISRUPTS) 18096514 1 0 0 +Myb Myb DNA-binding; Oncoprotein; Transcription factor P06876 17863 10 A3|10 9.75 cM mouse K441-ac 459083 DQTVKTQkENSIFRT Cmyb_C molecular association, regulation transcription, induced CBP(INDUCES) 11073948 1 2 0 +DGCR8 DGCR8 Nucleolus; RNA processing; RNA-binding Q8WYQ5 54487 22q11.21 human S397-p 25735891 FPLDEPDsMGADPGP protein stabilization 24239349 0 1 1 +Epor EPOR Membrane protein, integral; Receptor, cytokine P14753 13857 9 A3|9 7.93 cM mouse Y488-p 457448 DGPYSHPyENSLVPD carcinogenesis, induced; cell growth, induced 27998978 4 0 0 STAT5 acivation +HRAS HRas G protein; G protein, monomeric; G protein, monomeric, Ras; Motility/polarity/chemotaxis; Oncoprotein P01112 3265 11p15.5 human Y137-p 41198101 AQDLARSyGIPYIET Ras molecular association, regulation RASA1(INDUCES); RAF1(INDUCES) 25999467 2 1 0 +HDAC4 HDAC4 DEACETYLASE; Deacetylase; EC 3.5.1.98; Hydrolase; Nuclear receptor co-regulator; SUMO LIGASE P56524 9759 2q37.3 human S302-p 17797200 APGSGPSsPNNSSGS protein degradation; ubiquitination; intracellular localization cell motility, altered 21118993 1 0 0 +PARP1 PARP1 DNA repair, damage; EC 2.4.2.30; Nuclear envelope; Nuclear receptor co-regulator; Nucleolus; Transferase P09874 142 1q42.12 human S465-p 34729900 FLQDVSAsTKSLQEL enzymatic activity, induced 25069723 1 1 0 Non-apoptotic cell death induced +MYLK smMLCK EC 2.7.11.18; KINASE; Kinase, protein; Protein kinase, CAMK; Protein kinase, Ser/Thr (non-receptor) Q15746 4638 3q21.1 human T978-p 15423395 VPPPKPAtPDFRSVL molecular association, regulation; intracellular localization ACTN1(INDUCES) 34302892 1 3 2 +H2AX H2AX DNA repair, damage; DNA-binding; Helicase P16104 3014 11q23.3 human T136-p 455687 PSGGKKAtQASQEY_ molecular association, regulation; intracellular localization cell differentiation, inhibited; transcription, altered H1B(DISRUPTS) 16377563; 20356835; 33691101 6 14 11 +Cbx1 CBX1 Transcription factor P83917 12412 11 D|11 60.11 cM mouse S89-p 2906737 GGKRKADsDSEDKGE molecular association, regulation chromatin organization, altered; cell growth, induced; cell differentiation, induced; transcription, altered KRTAP1-1(INDUCES) 34214177 1 43 9 +POLI POLI DNA repair, damage; EC 2.7.7.7; Transferase Q9UNA4 11201 18q21.2 human K273-ub 22249762 GIGYKTAkCLEALGI protein degradation 26370087 1 5 0 +WNK1 WNK1 EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, Other; Protein kinase, Ser/Thr (non-receptor) Q9H4A3 65125 12p13.33 human S382-p 454105 KRASFAKsVIGTPEF Pkinase enzymatic activity, induced 17190791; 18270262; 22032326 9 10 3 +MALT1 MALT1 Adaptor/scaffold; Apoptosis; EC 3.4.22.-; Ligase; Nuclear export; Protease; UBIQUITIN LIGASE; Ubiquitin conjugating system Q9UDY8 10892 18q21.32 human S573-p 1869465811 GTEYSAEsLVRNLQW Peptidase_C14 carcinogenesis, induced; cell growth, induced; transcription, induced; signaling pathway regulation 31644910 1 1 0 activates transcription of NF-kB +PELI1 PELI1 Adaptor/scaffold; EC 6.3.2.-; EC 6.3.2.19; Ligase; UBIQUITIN LIGASE; Ubiquitin conjugating system; Ubiquitin ligase Q96FA3 57162 2p14 human T264-p 1881000300 EGLSHTPtVKHLEAL ubiquitination; enzymatic activity, induced carcinogenesis, induced; cell motility, induced 36841821 1 1 0 +ANXA2 ANXA2 Calcium-binding; Lipid-binding; Motility/polarity/chemotaxis P07355 302 15q22.2 human S26-p 450879 TPPSAYGsVKAYTNF molecular association, regulation; intracellular localization cell cycle regulation; cell motility, altered S100A10(DISRUPTS) 11106498; 12962548; 18412141; 21115493; 34331392 14 29 100 +GPR35 GPR35 GPCR, family 1; Membrane protein, integral; Membrane protein, multi-pass; Receptor, GPCR Q9HC97 2859 2q37.3 human S300-p 1876282808 PSAKAHKsQDSLCVT receptor internalization, induced; molecular association, regulation; intracellular localization ARR3(INDUCES) 35101446 1 1 0 +MYC Myc DNA-binding; Nucleolus; Oncoprotein; Transcription factor P01106 4609 8q24.21 human K66-sm 56403909 APSEDIWkKFELLPT Myc_N molecular association, regulation carcinogenesis, induced; cell growth, induced; transcription, induced JNK1(INDUCES) 27239040 1 0 0 +PDCD5 PDCD5 Apoptosis O14737 9141 19q13.11 human K20-ub 12246092 RLAELQAkHGDPGDA dsDNA_bind protein degradation; ubiquitination signaling pathway regulation 36578176 1 7 11 LNPPS suppresses the degradation of PDCD5 by masking its K20 site ubiquitination +PARP1 PARP1 DNA repair, damage; EC 2.4.2.30; Nuclear envelope; Nuclear receptor co-regulator; Nucleolus; Transferase P09874 142 1q42.12 human K521-ac 459007 EGINKSEkRMKLTLK molecular association, regulation transcription, induced NFkB-p105(INDUCES) 16204234 1 1 27 +BCAR1 P130Cas Adaptor/scaffold; Motility/polarity/chemotaxis P56945 9564 16q23.1 human Y267-p 451537 SQYGQEVyDTPPMAV cell growth, induced 26867768 3 21 285 metastases +RSC1A1 RSC1A1 Vesicle Q29106 pig S370-p 10433802 LHELLVIsSKPALEN intracellular localization 19765263 1 1 0 increases nuclear export +Htr1b 5-HT(1B) GPCR, family 1; Membrane protein, integral; Membrane protein, multi-pass; Receptor, GPCR P28334 15551 9 E1|9 44.61 cM mouse S154-p 10897604 ITDAVEYsAKRTPKR 7tm_1 activity, induced; receptor internalization, altered 19741007 1 0 0 +Cspg4 NG2 Cell adhesion; Membrane protein, integral Q00657 81651 8q24 rat T2314-p 483998 ELLQFCRtPNPALRN intracellular localization cell growth, altered 17591920 1 0 1 +MAP2K7 MKK7 EC 2.7.12.2; KINASE; Kinase, protein; Protein kinase, STE; Protein kinase, dual-specificity (non-receptor) O14733 5609 19p13.2 human T275-p 447698 LVDSKAKtRSAGCAA Pkinase enzymatic activity, induced transcription, altered 9312068 2 0 1 +Axin1 axin 1 Adaptor/scaffold; Tumor suppressor O35625 12005 17 A3.3|17 13.07 cM mouse T160-p 3072727 NGIVSRQtKPATKSF RGS molecular association, regulation signaling pathway regulation CTNNB1(DISRUPTS); APC(DISRUPTS); BTRC(DISRUPTS) 25735981 1 2 0 activates Wnt/beta-catenin signaling +SENP3 SENP3 DESUMOYLASE; EC 3.4.22.68; Nucleolus; Protease; Sumo-specific protease Q9H4L4 26168 17p13.1 human T145-p 36438202 YSKSTSLtFHWKLWG molecular association, regulation; intracellular localization NPM1(INDUCES) 25288641 1 1 0 ribosome biogenesis-28S rRNA maturation +SLC6A2 SLC6A2 Membrane protein, integral; Membrane protein, multi-pass; Transporter; Transporter, SLC family P23975 6530 16q12.2 human T258-p 465613 SLWKGVKtSGKVVWI SNF receptor internalization, induced; intracellular localization; activity, inhibited 16740633; 23979140 2 0 0 Raft-rich membrane domains serve as transit cargos for transporter internalization.; effect observed in T258, S259 double mutant +REPS1 REPS1 Vesicle Q96D71 85021 6q24.1 human S709-p 478670 PVRRRLKsEDELRPE receptor recycling, induced 33407999 1 62 511 +Jak2 JAK2 EC 2.7.10.2; KINASE; Kinase, protein; Oncoprotein; Protein kinase, TK; Protein kinase, tyrosine (non-receptor) Q62120 16452 19 C1|19 23.73 cM mouse Y372-p 7603504 FVSLIDGyYRLTADA Jak1_Phl protein stabilization; molecular association, regulation; phosphorylation; enzymatic activity, induced transcription, induced; signaling pathway regulation JAK2(INDUCES); STAT1(INDUCES) 21726629 2 2 0 dimerization; induces autophosphorylation at Y1007; regulates JAK-STAT signaling, stabilization in active conformation +NR4A1 Nur77 Apoptosis; DNA-binding; Nuclear receptor P22736 3164 12q13.13 human K577-sm 1873041100 LQRIFYLkLEDLVPP Hormone_recep protein degradation; ubiquitination transcription, inhibited 28622293 1 0 0 inhibits TNF-alpha and IL-1beta-induced NF-kB activity +Itpka ITPKA Carbohydrate Metabolism - inositol phosphate; EC 2.7.1.127; Kinase, lipid; Motility/polarity/chemotaxis Q8R071 228550 2|2 E5 mouse S119-p 4763186 LQQPRRLsTSSLSST molecular association, regulation neural plasticity; cytoskeletal reorganization 22389500 2 0 0 Phosphorylation at S119 inhibits the ITPKA and microtubule binding +CMKLR1 CMKLR1 GPCR, family 1; Membrane protein, integral; Membrane protein, multi-pass; Receptor, GPCR Q99788 1240 12q23.3 human S349-p 4713136 TGHSSYPsHRSFTKM receptor internalization, induced 24658352 1 7 0 +RAF1 RAF1 EC 2.7.11.1; KINASE; Kinase, protein; Oncoprotein; Protein kinase, Ser/Thr (non-receptor); Protein kinase, TKL P04049 5894 3p25.2 human S29-p 455310 FDGSSCIsPTIVQQF molecular association, regulation; intracellular localization; enzymatic activity, inhibited HRas(DISRUPTS) 15664191 3 13 2 +CTNNB1 CTNNB1 Actin-binding; Cell adhesion; Motility/polarity/chemotaxis; Nuclear receptor co-regulator; Oncoprotein; Transcription factor P35222 1499 3p22.1 human S675-p 457120 QDYKKRLsVELTSSL activity, induced; molecular association, regulation; protein stabilization; intracellular localization carcinogenesis, induced; cell motility, induced; cell growth, induced; transcription, induced; transcription, altered; signaling pathway regulation TCF4(INDUCES); HDAC1(DISRUPTS); p300(INDUCES); CDH1(INDUCES); BTRC(DISRUPTS) 16199882; 16476742; 20419129; 21822311; 22173096; 27162341; 27484798; 33815677; 33832512; 33914026; 34262144; 34799729; 35131384; 36000549; 36626902 40 55 17 +FPR1 FPR1 GPCR, family 1; Membrane protein, integral; Membrane protein, multi-pass; Motility/polarity/chemotaxis; Receptor, GPCR P21462 2357 19q13.41 human T339-p 450846 SDTATNStLPSAEVE receptor desensitization, altered; receptor internalization, altered 10514456 1 0 0 +Nfkbia IkB-alpha DNA-binding; Inhibitor Q63746 25493 6q23 rat Y42-p 448737 DSMKDEDyEQMVKEL activity, induced cell growth, altered 15935065 15 1 28 +H2AX H2AX DNA repair, damage; DNA-binding; Helicase P16104 3014 11q23.3 human K15-ub 55610204 GKARAKAkSRSSRAG Histone intracellular localization DNA repair, induced; carcinogenesis, inhibited; cell growth, inhibited; DNA repair, altered 22980979; 27345151; 32213544; 35598681 5 0 0 +MCM2 MCM2 DNA-binding; EC 3.6.4.12 P49736 4171 3q21.3 human S41-p 452312 RTDALTSsPGRDLPP activity, induced; molecular association, regulation cell cycle regulation; chromatin organization, altered DNA(NOT_REPORTED); DNA(INDUCES) 16446360; 16899510 8 60 23 MMCM2 phosphorylated forms are differentially bound to chromatin. ; regulates ATPase activity in vitro +MAVS MAVS Adaptor/scaffold; Membrane protein, integral Q7Z434 57506 20p13 human R43-me 1883504203 ARDQDRLrATCTLSG activity, inhibited 36028484 1 1 0 PRMT9-mediated MAVS methylation inhibits MAVS aggregation and activation. +CRY2 CRY2 DNA-binding; Lyase Q49AN0 1408 11p11.2 human T300-p 40584904 KKVKRNStPPLSLFG protein degradation; molecular association, regulation; ubiquitination FBXW7(INDUCES) 25855785 1 0 0 faster turnover rate in the presence of FBXW7 +CTNNB1 CTNNB1 Actin-binding; Cell adhesion; Motility/polarity/chemotaxis; Nuclear receptor co-regulator; Oncoprotein; Transcription factor P35222 1499 3p22.1 human S311-p 1881000308 LAYGNQEsKLIILAS protein stabilization; molecular association, regulation; intracellular localization carcinogenesis, induced; cell motility, induced; cell growth, induced; transcription, altered; signaling pathway regulation TCF4(NOT_REPORTED) 36793862 1 1 0 induces ?-catenin/AP-1/PLK1 signaling +FER Fer EC 2.7.10.2; KINASE; Kinase, protein; Oncoprotein; Protein kinase, TK; Protein kinase, tyrosine (non-receptor) P16591 2241 5q21.3 human Y402-p 457934 EPPPVVNyEEDARSV cell motility, inhibited 37196766 2 39 613 +MDC1 MDC1 Cell cycle regulation Q14676 9656 6p21.33 human T220-p 4213801 AFNLNSDtDVEEGQQ molecular association, regulation cell cycle regulation NBS1(INDUCES) 18678890 1 1 5 MDC1-NBS1 interaction regulates intra-S-phase checkpoint activation +FOS Fos DNA-binding; Motility/polarity/chemotaxis; Oncoprotein; Transcription factor P01100 2353 14q24.3 human T232-p 448491 GGLPEVAtPESEEAF activity, induced; intracellular localization; phosphorylation carcinogenesis, induced; cell motility, induced; transcription, induced; transcription, altered 16055710; 17018293; 23667255; 27014871; 7816602 6 0 0 +PDHA1 PDHA1 Amino Acid Metabolism - valine, leucine and isoleucine biosynthesis; Carbohydrate Metabolism - butanoate; Carbohydrate Metabolism - citrate (TCA) cycle; Carbohydrate Metabolism - glycolysis and gluconeogenesis; Carbohydrate Metabolism - pyruvate; EC 1.2.4.1; Mitochondrial; Oxidoreductase P08559 5160 Xp22.12 human S300-p 448259 SMSDPGVsYRTREEI E1_dh activity, induced; protein degradation; molecular association, regulation; ubiquitination; enzymatic activity, inhibited carcinogenesis, induced; cell growth, induced; apoptosis, inhibited emerin(INDUCES) 11092882; 17065338; 22289032; 25243911; 25404640; 27357730; 28122247; 30697423; 30797950; 32993545; 34667275; 36071546; 7782287 53 76 476 +SSTR2 SSTR2 GPCR, family 1; Membrane protein, integral; Membrane protein, multi-pass; Receptor, GPCR P30874 6752 17q25.1 human S341-p 7652103 GTDDGERsDSKQDKS receptor desensitization, induced; receptor internalization, induced; receptor recycling, induced; receptor internalization, altered 21330405; 21343287; 22538189; 24565897; 24637622; 25012983 10 0 0 +TP53 p53 Activator; DNA-binding; Motility/polarity/chemotaxis; Nuclear receptor co-regulator; Transcription factor; Tumor suppressor P04637 7157 17p13.1 human S9-p 447538 EEPQSDPsVEPPLSQ P53_TAD molecular association, regulation; acetylation; intracellular localization; protein conformation; phosphorylation cell cycle regulation; apoptosis, altered; carcinogenesis, inhibited; apoptosis, induced; transcription, induced; transcription, altered 11875057; 12860987; 14665630; 15322239; 18769132; 18794113; 34282274; 36007676 39 3 1 CRp53 +Ctnnb1 CTNNB1 Actin-binding; Cell adhesion; Motility/polarity/chemotaxis; Nuclear receptor co-regulator; Oncoprotein; Transcription factor Q02248 12387 9 F4|9 72.19 cM mouse K233-sm 1883364802 EGLLAIFkSGGIPAL intracellular localization 36306558 1 0 0 epithelial barrier dysfunction in asthma +Cacna1a CACNA1A Channel, calcium; Membrane protein, integral; Membrane protein, multi-pass P97445 12286 8 C2|8 40.95 cM mouse S2363-p 4713052 AHDAYSEsEDDWC__ activity, induced 32630015 1 3 0 regulates Ca2+ entry and insulin secretion in pancreatic-beta cells +Dicer1 DICER1 Cell development/differentiation; EC 3.1.26.3; Helicase; RNA processing; RNA-binding; Ribonuclease Q8R418 192119 12 E|12 54.83 cM mouse S1456-p 31084113 IDSMLMGsGAFVRKI Ribonuclease_3 protein degradation 29907159 1 3 0 inflammatory response +Stxbp5 STXBP5 Vesicle Q9WU70 81022 1p13 rat K298-sm 31957310 EPCKPILkVEFKTTR LLGL molecular association, regulation exocytosis, inhibited STX1A(INDUCES) 28325894 2 0 0 +Rb1 Rb Nuclear receptor co-regulator; Oncoprotein; Transcription, coactivator/corepressor; Tumor suppressor P33568 24708 15q11 rat S780-p 450022 PIPHIPRsPYKFSSS Rb_C molecular association, regulation HDAC1(INDUCES) 19081374 12 20 79 +TRIM28 TIF1B EC 6.3.2.-; KINASE; Kinase, protein; Ligase; Nuclear receptor co-regulator; Protein kinase, atypical; SUMO LIGASE; SUMO ligase; Transcription, coactivator/corepressor; UBIQUITIN LIGASE; Ubiquitin conjugating system; Ubiquitin ligase Q13263 10155 19q13.43 human Y517-p 464439 PGSTTEDyNLIVIER molecular association, regulation; phosphorylation DNA repair, induced HP1 alpha(INDUCES) DNA(NOT_REPORTED) 23645696 1 6 131 stimulates phosphorylation of TIF1B S473 and TIF1B S824 in DNA damage response; involved in DNA damage response; inhibits association of HP1alpha with chromatin +Traf2 TRAF2 Autophagy; EC 6.3.2.-; Ligase; UBIQUITIN LIGASE; Ubiquitin conjugating system; Ubiquitin ligase P39429 22030 2|2 A3 mouse K38-ub 486267 KYLCSACkNILRRPF zf-C3HC4 protein degradation 11909853 1 0 0 +Rb1cc1 RB1CC1 Autophagy; DNA-binding; Transcription factor; Tumor suppressor Q9ESK9 12421 1|1 A1 mouse S536-p 470654 AEKSKREsFGKLFRK ATG17_like intracellular localization carcinogenesis, inhibited 35220675 1 1 0 +ATF1 ATF-1 Transcription factor P18846 466 12q13.12 human S36-p 465558 AQQVSSLsESEESQD molecular association, regulation; phosphorylation CBP(DISRUPTS) 20730097 4 1 0 primes for S47/S50/S51 phosphorylation +PTGER4 PTGER4 GPCR, family 1; Membrane protein, integral; Membrane protein, multi-pass; Receptor, GPCR P35408 5734 5p13.1 human S382-p 450698 GHSRSFIsRELKEIS molecular association, regulation ARRB1(INDUCES) 14709160 1 0 0 +RAPH1 RAPH1 Adaptor/scaffold; Motility/polarity/chemotaxis Q70E73 65059 2q33.2 human Y456-p 26348502 NVYYGQDyRNKYKAP PH molecular association, regulation cell motility, induced 26996666 2 0 0 Lpd-Scar/WAVE interaction is positively regulated by c-Abl and c-Src, breast cancer cell invasion +DVL3 DVL3 Motility/polarity/chemotaxis Q92997 1857 3q27.1 human S639-p 34668134 HSHRSHHsLASSLRS Dsh_C intracellular localization 24993822 1 1 0 +SMAD3 SMAD3 DNA-binding; Nuclear receptor co-regulator; Transcription factor P84022 4088 15q22.33 human S425-p 448336 SIRCSSVs_______ activity, induced; intracellular localization; protein conformation carcinogenesis, induced; cell differentiation, induced; cell motility, altered; transcription, induced; transcription, altered; signaling pathway regulation 19115199; 21148321; 25140527; 31995604; 34003249; 35075279; 36461015; 9380693 41 0 5 The triple mutants(S422/423/425A and S422/423/425D) were used in these experiments +PPP1R14D GBPI-1 Inhibitor; Protein phosphatase, regulatory subunit Q9NXH3 54866 15q15.1 human T58-p 450935 SRRPSRLtVKYDRGQ PP1_inhibitor phosphorylation 12974676 1 0 0 Phosphorylated GBPI-1 inhibits PP1 activity. Point mutant does not. +RBM7 RBM7 RNA-binding Q9Y580 10179 11q23.2 human S136-p 453069 QIIQRSFsSPENFQR molecular association, regulation 14-3-3 beta(INDUCES); GADD45A(DISRUPTS) 25189701 2 50 103 14-3-3 protein binding +Tln1 talin 1 Cytoskeletal; Motility/polarity/chemotaxis P26039 21894 4|4 A5 mouse S425-p 1984203 TMLEDSVsPKKSTVL cell motility, induced; cell growth, induced 36207442 7 44 2 +Ncor1 N-CoR1 Nuclear receptor co-regulator; Transcription, coactivator/corepressor Q60974 20185 11|11 B2 mouse K1117-sm 3755601 AAPLTYIkQEEFSPR transcription, inhibited 16421255 1 4 0 +Gjb3 GJB3 Channel, misc.; Membrane protein, integral; Membrane protein, multi-pass P28231 14620 4 D2.2|4 61.48 cM mouse S263-p 2907501 ASEKLQAsAPSLTPI activity, induced; protein stabilization 15023533 1 2 0 +Fxyd1 PLM Cell surface; Channel, misc.; Membrane protein, integral Q9Z239 56188 7|7 B1 mouse S88-p 451425 RSSIRRLsSRRR___ activity, induced; intracellular localization 16371442; 21957166 27 3 74 Na K pump activity; After stimulation with phorbol ester. +FFAR4 GPR120 iso1 GPCR, family 1; Lipid-binding; Membrane protein, integral; Membrane protein, multi-pass; Receptor, GPCR Q5NUL3-1 338557 10q23.33 human T365-p 33638004 KGAILTDtSVKRNDL receptor internalization, induced; molecular association, regulation ARR3(INDUCES) 24817122 2 1 0 +IRF4 IRF4 DNA-binding; Oncoprotein; Transcription factor Q15306 3662 6p25.3 human Y62-p 28700300 KHAGKQDyNREEDAA IRF activity, induced transcription, induced 23804646 1 0 0 +Rps6 S6 Translation P62755 29304 5q32 rat S235-p 448092 IAKRRRLsSLRASTS signaling pathway regulation 21949366 246 60 972 +ATM ATM DNA repair, damage; EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, Ser/Thr (non-receptor); Protein kinase, atypical; Tumor suppressor Q13315 472 11q22.3 human S367-p 467198 DTRSLEIsQSYTTTQ enzymatic activity, induced 21149446 3 9 2 +KIF20A KIF20A Microtubule-binding; Motor O95235 10112 5q31.2 human S878-p 4712595 RILRSRRsPLLKSGP molecular association, regulation; intracellular localization; protein conformation cell cycle regulation; cytoskeletal reorganization AurB(DISRUPTS); INCENP(DISRUPTS) 24656812; 27939310 2 9 0 favours solubility, inhibits microtubule binding; inhibits abscission +SNAI2 Snail2 Apoptosis; C2H2-type zinc finger protein; Motility/polarity/chemotaxis; Transcription factor O43623 6591 8q11.21 human T208-p 25311911 QGHIRTHtGEKPFSC protein stabilization carcinogenesis, induced; cell motility, induced 35859006 1 0 1 +PXN PXN Adaptor/scaffold; Cell adhesion; Cytoskeletal; Motility/polarity/chemotaxis P49023 5829 12q24.23 human Y118-p 448604 VGEEEHVySFPNKQK Paxillin molecular association, regulation; intracellular localization; phosphorylation cell differentiation, inhibited; carcinogenesis, induced; cell motility, induced; cell adhesion, induced; signaling pathway regulation; cell adhesion, inhibited; autophagy, induced; cell growth, induced; cytoskeletal reorganization TACE(INDUCES); ERK2(INDUCES); ERK1(INDUCES); DRP1(INDUCES); CBL(INDUCES); LC3A(INDUCES) 23317503; 26091349; 26697169; 28415719; 33823745; 34226698; 34335982; 34475475; 35297710 83 79 2519 +DAPP1 DAPP1 Adaptor/scaffold Q9UN19 27071 4q23 human S141-p 14510068 EEPSIYEsVRVHTAM molecular association, regulation; phosphorylation; enzymatic activity, induced signaling pathway regulation PLCG1(INDUCES) 22981863 1 1 4 +IGF1R IGF1R EC 2.7.10.1; KINASE; Kinase, protein; Membrane protein, integral; Protein kinase, TK; Protein kinase, tyrosine (receptor) P08069 3480 15q26.3 human S1312-p 2091901 LDPSASSsSLPLPDR activity, induced; phosphorylation cell differentiation, altered; apoptosis, altered; cell growth, altered 10746631; 10786694 2 1 0 observed in Y980F + S1310-1313A; ERK phosphorylation +TARDBP TDP-43 RNA-binding Q13148 23435 1p36.22 human S48-p 18914091 LRYRNPVsQCMRGVR TDP43_N molecular association, regulation; protein conformation TDP-43(DISRUPTS) 29438978; 35040651 2 1 1 +CTPS1 CTPS EC 6.3.4.2; Ligase; Motility/polarity/chemotaxis; Nucleotide Metabolism - pyrimidine P17812 1503 1p34.2 human S575-p 449144 SDRSGSSsPDSEITE molecular association, regulation; activity, inhibited; phosphorylation PIN1(INDUCES) 17681942; 18600551 2 73 11 +Cdh5 CDH5 Cell adhesion; Membrane protein, integral; Motility/polarity/chemotaxis P55284 12562 8 D3|8 53.04 cM mouse Y658-p 456048 GEMDTTSyDVSVLNS activity, induced; molecular association, regulation; receptor recycling, induced GPSM2(INDUCES); CTNND1(DISRUPTS) 20530207; 28712573; 32327488 13 0 0 induces VE-cadherin trafficking to adherent junctions +ESR1 ER-alpha DNA-binding; Nuclear receptor; Transcription factor P03372 2099 6q25.1-q25.2 human K268-sm 3617605 GGRMLKHkRQRDDGE molecular association, regulation transcription, induced DNA(INDUCES) 15961505 1 0 0 +DDIT3 DDIT3 Autophagy; DNA-binding; Oncoprotein; Transcription factor P35638 1649 12q13.3 human S14-p 455501 PFSFGTLsSWELEAW activity, inhibited transcription, inhibited 12876286 1 0 0 +IL2RB IL2RB Membrane protein, integral; Receptor, cytokine P14784 3560 22q12.3 human Y364-p 455360 SCFTNQGyFFFHLPD molecular association, regulation transcription, induced SHC1(INDUCES) 10602027; 18348982; 7499411; 8643566 5 0 0 mediated by PI3K pathway through Y364 +Ybx1 YB-1 RNA processing; RNA splicing; RNA-binding; Transcription factor P62960 22608 4|4 D2.1 mouse Y70-p 3797338 WFNVRNGyGFINRND CSD carcinogenesis, induced; translation, induced 36044842 1 0 24 +MYL9 MRLC1 Contractile; Motility/polarity/chemotaxis P24844 10398 20q11.23 human T19-p 1863501 KKRPQRAtSNVFAMF activity, induced; molecular association, regulation; intracellular localization cell adhesion, induced; cytoskeletal reorganization; signaling pathway regulation 22136066; 26169356; 31834925; 37064875 28 53 281 +DGCR8 DGCR8 Nucleolus; RNA processing; RNA-binding Q8WYQ5 54487 22q11.21 human S271-p 3208077 EEKYGGDsDHPSDGE protein stabilization 24239349 1 33 3 +Eef1a1 EEF1A1 Nucleolus; Translation; Translation elongation P10126 13627 9|9 E1 mouse K165-m1 8113920 TEPPYSQkRYEEIVK GTP_EFTU molecular association, regulation translation, altered EEF1D(DISRUPTS); eEF1B(DISRUPTS); EEF1G(DISRUPTS) 28108655 2 8 46 +Smarca2 SMARCA2 EC 3.6.1.-; EC 3.6.4.-; Helicase; Nuclear receptor co-regulator; Transcription, coactivator/corepressor Q6DIC0 67155 19 C1|19 21.17 cM mouse K1540-ac 460621 EKGRDTGkGKKRPNR molecular association, regulation; protein conformation cell growth, induced; transcription, inhibited Rb(DISRUPTS) DNA(DISRUPTS) 14657023 1 1 67 +P2RX3 P2X3 Channel, ligand-gated; Membrane protein, integral; Membrane protein, multi-pass P56373 5024 11q12.1 human T134-p 458895 LPGGGILtGRCVNYS P2X_receptor receptor desensitization, altered 16226373 1 0 0 +PRKCE PKCE EC 2.7.11.13; KINASE; Kinase, protein; Protein kinase, AGC; Protein kinase, Ser/Thr (non-receptor) Q02156 5581 2p21 human Y573-p 764200 TFCGTPDyIAPEILQ Pkinase molecular association, regulation PLCG1(INDUCES) 17561374 1 0 0 +KDR VEGFR2 EC 2.7.10.1; KINASE; Kinase, protein; Membrane protein, integral; Protein kinase, TK; Protein kinase, tyrosine (receptor) P35968 3791 4q12 human Y801-p 450277 GGELKTGyLSIVMDP activity, induced; molecular association, regulation; phosphorylation PIK3R1(INDUCES) 14532277; 17303569 4 1 2 PIK3R1, eNOS, and AKT phosphorylation; necessary for TNF but not VEGF activation of AKT; stimulates NO2 release +RIGI RIGI EC 3.6.4.13; Hydrolase O95786 23586 9p21.1 human K193-ub 486288 WIVEKGIkDVETEDL protein degradation 31881323 3 3 0 +ERBB4 HER4 EC 2.7.10.1; KINASE; Kinase, protein; Membrane protein, integral; Protein kinase, TK; Protein kinase, tyrosine (receptor) Q15303 2066 2q34 human Y1242-p 451502 KAFDNPDyWNHSLPP molecular association, regulation GRB2(INDUCES); Arg(INDUCES); SHC1(INDUCES) 16729043; 18721752; 8617750 2 2 3 +Kcnk18 KCNK18 Channel, ligand-gated; Channel, potassium; Membrane protein, integral; Membrane protein, multi-pass Q6VV64 332396 19|19 D3 mouse S279-p 13383301 RLSCSILsNLDEVGQ activity, inhibited 20215114; 22145024 3 0 0 K+ channel activity inhibited +Sdc1 syndecan-1 Extracellular matrix; Membrane protein, integral; Motility/polarity/chemotaxis P18828 20969 12 A1.1|12 3.94 cM mouse S286-p 469564 MKKKDEGsYSLEEPK Syndecan intracellular localization 16807246 1 8 1 +Kit Kit EC 2.7.10.1; KINASE; Kinase, protein; Membrane protein, integral; Oncoprotein; Protein kinase, TK; Protein kinase, tyrosine (receptor) P05532 16590 5 C3.3|5 39.55 cM mouse Y573-p 448015 INGNNYVyIDPTQLP cell growth, inhibited 28923937 9 3 12 +SNRPB snRNP B1 RNA processing; RNA splicing; RNA-binding; Spliceosome P14678 6628 20p13 human R112-m2 476754 GIGRAAGrGIPAGVP molecular association, regulation SMN(INDUCES) 11720283 1 7 26 +Becn1 beclin 1 Adaptor/scaffold; Autophagy; Membrane protein, peripheral O88597 56208 11|11 D mouse S14-p 25268704 SSSTMQVsFVCQRCS carcinogenesis, induced; autophagy, induced; cell growth, induced 23685627; 35246531 11 1 0 +TP53BP1 53BP1 DNA repair, damage; Transcription, coactivator/corepressor Q12888 7158 15q15.3 human R1396-me 2344821 GKAPVTPrGRGRRGR molecular association, regulation DNA(INDUCES) 16294045 2 0 0 +IGF2BP2 IGF2BP2 RNA-binding; Translation Q9Y6M1 10644 3q27.2 human K505-sm 1881342901 EENFFNPkEEVKLEA protein stabilization cell growth, induced 34345216 1 0 0 promotes vasculogenic mimicry (VM) formation in glioma cells +Cd22 CD22 Cell surface; Membrane protein, integral P35329 12483 7 B1|7 19.26 cM mouse Y783-p 458398 AMDDTVSyAILRFPE molecular association, regulation; activity, inhibited; phosphorylation SHP-1(INDUCES) 18024433; 27276708 5 0 1 negatively regulate calcium signal +Grin2c NMDAR2C Channel, calcium; Channel, ligand-gated; Membrane protein, integral; Membrane protein, multi-pass Q00961 24411 10q32.1 rat S1083-p 7979604 GPRPRHAsLPSSVAE molecular association, regulation; intracellular localization 14-3-3 beta(INDUCES); 14-3-3 theta(INDUCES); 14-3-3 zeta(INDUCES); 14-3-3 epsilon(INDUCES); 14-3-3 gamma(INDUCES); 14-3-3 eta(INDUCES) 19477150; 26229101 2 0 0 regulates GluN2C-containing NMDAR receptor trafficking +KCNB1 Kv2.1 Channel, cation; Channel, ligand-gated; Channel, potassium; Membrane protein, integral; Membrane protein, multi-pass Q14721 3745 20q13.13 human K474-sm 25087004 KNGENMGkKDKVQDN Kv2channel exocytosis, inhibited 31085831 2 1 0 controlled the occurrence of membrane fusion +SP1 SP1 C2H2-type zinc finger protein; DNA-binding; Transcription factor P08047 6667 12q13.13 human S42-p 3180261 FSQARSSsTGSSSST protein stabilization; molecular association, regulation carcinogenesis, induced; cell motility, induced; transcription, induced; signaling pathway regulation DNA(INDUCES) 22718198 1 1 0 AKT/SP1/CCR7 pathway +HSP90AA1 HSP90A Chaperone; Heat shock protein P07900 3320 14q32.31 human R386-me 1871626200 PEYLNFIrGVVDSED HSP90 molecular association, regulation apoptosis, inhibited AHSA1(INDUCES) 31765670 1 1 0 +EIF2AK4 GCN2 EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, Other; Protein kinase, Ser/Thr (non-receptor); Translation Q9P2K8 440275 15q15.1 human T899-p 455461 SDPSGHLtGMVGTAL Pkinase protein stabilization; molecular association, regulation apoptosis, induced; translation, induced ARRB1(DISRUPTS); ARRB2(DISRUPTS) 25589675; 36898579 5 0 0 +Xrcc6 Ku70 DNA repair, damage; DNA-binding; EC 3.6.4.-; EC 4.2.99.-; Helicase; Nuclear receptor co-regulator; RNA-binding P23475 14375 15 E1|15 38.33 cM mouse S49-p 10211800 ASRAMFEsQGEDELT Ku_N molecular association, regulation BAX(DISRUPTS) 19664609 2 0 0 kainate treatment increases interaction of Ku70 with Bax +FBXL20 FBXL20 UBIQUITIN LIGASE; Ubiquitin ligase Q96IG2 84961 17q12 human S255-p 1875005606 KLQSLCAsGCSNITD protein degradation; molecular association, regulation carcinogenesis, inhibited; cell growth, inhibited; apoptosis, induced FBXO31(INDUCES) 34587475 1 0 0 +Gja1 GJA1 Channel, misc.; Membrane protein, integral; Membrane protein, multi-pass; Motility/polarity/chemotaxis P23242 14609 10 B4|10 28.64 cM mouse S364-p 450183 AIVDQRPsSRASSRA intracellular localization; protein conformation 17714073 6 8 0 S363, S364 phosphorylation prevent an antibody to the Cx43 C-terminus. +KCNK3 KCNK3 Channel, potassium; Membrane protein, integral; Membrane protein, multi-pass O14649 3777 2p23.3 human S336-p 21336507 IPRDLSTsDTCVEQS activity, inhibited 21838752 1 1 1 +LTF LTF EC 3.4.21.-; Protease; Secreted; Secreted, signal peptide P02788 4057 3p21.31 human K352-sm 41400402 TAIQNLRkSEEEVAA Transferrin transcription, inhibited 26090800 1 0 0 +CNTROB LIP8 Cell cycle regulation Q8N137 116840 17p13.1 human S41-p 27565613 VTSQLYAsLRLSRQA cell motility, inhibited 23291182 1 0 0 +Maf MAF Cell development/differentiation; DNA-binding; Oncoprotein; Transcription factor; Tumor suppressor P54843 17132 8 E1|8 62.61 cM mouse K33-sm 8474100 DLMKFEVkKEPVETD molecular association, regulation; intracellular localization transcription, inhibited DNA(DISRUPTS) 19553542; 20127678 2 0 0 recruitment of MAF to the IL-4 gene +MAPT Tau iso8 ACETYLTRANSFERASE; Acetyltransferase; Cytoskeletal P10636-8 4137 17q21.31 human S404-p 449082 PVVSGDTsPRHLSNV O-GlcNAc glycosylation; molecular association, regulation; protein processing; intracellular localization; protein conformation; phosphorylation apoptosis, induced; cytoskeletal reorganization TUBA1A(DISRUPTS); TUBA4A(DISRUPTS); Tau iso8(INDUCES); TUBB(DISRUPTS) 10818091; 11034902; 12414518; 14761950; 15190058; 15542598; 16478768; 16687396; 18052981; 18725412; 19451179; 34220449; 35298090; 36079767 145 54 69 +RPL11 RPL11 Motility/polarity/chemotaxis; Nucleolus; Ribosomal; Translation P62913 6135 1p36.11 human K96-ne 12067614 VREYELRkNNFSDTG Ribosomal_L5_C protein stabilization; intracellular localization 19713960 1 0 0 +FHIT FHIT DNA replication; EC 3.6.1.29; Hydrolase; Motility/polarity/chemotaxis; Nucleotide Metabolism - purine; Tumor suppressor P49789 2272 3p14.2 human Y114-p 447802 FHRNDSIyEELQKHD protein degradation; intracellular localization; enzymatic activity, inhibited; activity, inhibited cell cycle regulation; apoptosis, altered; apoptosis, induced; cell growth, altered HSP60(INDUCES); FDXR(INDUCES) 15835917; 16407838; 17142325; 19004824 4 1 0 localization to the mitochondria; Overepression of wt FHIT promotes apoptosis but not the Y113A or Y113F mutation. +IL6ST gp130 Membrane protein, integral; Receptor, cytokine P40189 3572 5q11.2 human T890-p 455688 GQVERFEtVGMEAAT molecular association, regulation 12361954 1 0 1 +Tagln TAGLN Actin-binding; Motility/polarity/chemotaxis; Nuclear receptor co-regulator P31232 25123 8q22 rat S181-p 469978 VIGLQMGsNRGASQA Calponin protein degradation; molecular association, regulation; ubiquitination; phosphorylation cytoskeletal reorganization; signaling pathway regulation PKCD(DISRUPTS) 22798525 3 15 14 p47phox phosphorylation, PKCD-p47phox signaling, ROS production induced with vascular remodelling +PRLR PRLR Membrane protein, integral; Receptor, cytokine P16471 5618 5p13.2 human T415-p 449611 AGGSKCStWPLPQPS molecular association, regulation; phosphorylation transcription, altered 14-3-3 zeta(INDUCES); 14-3-3 gamma(INDUCES) 12819209 1 0 0 phosphorylation reduces tyrosine phosphorylation after prolactin stimulation as well as activation of ERK and AKT +MLXIP MLXIP Q9HAP2 22877 12q24.31 human Y222-p 40556408 IEIVIREyHKWRTYF molecular association, regulation; intracellular localization carcinogenesis, induced; cell growth, induced; apoptosis, inhibited; transcription, inhibited 14-3-3 beta(INDUCES) DNA(DISRUPTS) 36398713 1 1 0 +LPIN1 LPIN1 EC 3.1.3.4; Phosphatase, lipid Q14693 23175 2p25.1 human Y795-p 1871177712 FPNTEPFyAAFGNRP LNS2 enzymatic activity, induced carcinogenesis, induced; cell growth, induced 33203880 1 1 0 Activity of PAP, increase glycolipid synthesis +Snap23 SNAP23 Vesicle O70377 64630 3q35 rat S160-p 4148814 ENLTQVGsILGNLKN exocytosis, altered 20967886 2 18 14 +Dab1 DAB1 iso3 Adaptor/scaffold P97318-3 13131 4 C6|4 47.79 cM mouse S246-p 479425 PVSSLVQsPAAERAE protein degradation; phosphorylation 16529723 1 0 0 enhances tyrosine phosphorylation and protein degradation +Ets1 Ets-1 DNA-binding; Motility/polarity/chemotaxis; Oncoprotein; Transcription factor P27577 23871 9 A4|9 17.97 cM mouse S282-p 449317 NSLQRVPsYDSFDYE Ets1_N_flank molecular association, regulation; acetylation; intracellular localization transcription, inhibited DNA(DISRUPTS) 30865889 7 10 87 induce acetylation of FOXO1 and suppress gluconeogenesis +Tbc1d4 AS160 GAP; GAP, Rab Q8BYJ6 210789 14|14 E2.3 mouse S758-p 455924 EGRKRTSsTCSNESL phosphorylation 19923418 10 10 48 TBC1D4 S318/S588/T642/S751A mutation decreases phosphorylation of S711 +GRK7 GRK7 EC 2.7.11.14; EC 2.7.11.16; KINASE; Kinase, protein; Protein kinase, AGC; Protein kinase, Ser/Thr (non-receptor) Q8WTQ7 131890 3q23 human S36-p 456355 ELQRRRRsLALPGLQ enzymatic activity, inhibited 15946941 2 0 0 reaction in vitro +CDK9 CDK9 Cell cycle regulation; EC 2.7.11.22; EC 2.7.11.23; KINASE; Kinase, protein; Nuclear receptor co-regulator; Protein kinase, CMGC; Protein kinase, Ser/Thr (non-receptor) P50750 1025 9q34.11 human S90-p 41625400 EICRTKAsPYNRCKG Pkinase transcription, induced 23140174 2 0 0 Tat-induced HIV-1 transcription +USP9X USP9X DEUBIQUITINASE; EC 3.4.19.12; Protease; Ubiquitin conjugating system; Ubiquitin-specific protease Q93008 8239 Xp11.4 human S2547-p 483796 YEGSEEVsPPQTKDQ molecular association, regulation; enzymatic activity, induced WIT1(INDUCES) 32152317 1 28 1 +EZH2 EZH2 EC 2.1.1.43; METHYLTRANSFERASE; Methyltransferase; Methyltransferase, protein lysine Q15910 2146 7q36.1 human Y641-p 31825502 KNEFISEyCGEIISQ SET protein stabilization; molecular association, regulation; ubiquitination BTRC(INDUCES) 24469040 1 0 0 +Epha8 EphA8 EC 2.7.10.1; KINASE; Kinase, protein; Membrane protein, integral; Protein kinase, TK; Protein kinase, tyrosine (receptor) O09127 13842 4|4 D3 mouse Y838-p 448559 LAYGERPyWNMTNQD PK_Tyr_Ser-Thr enzymatic activity, induced cell adhesion, altered 10498895 1 0 0 Y383 phosphorylation is required for efficient phosphorylation of Y615 and other major sites. +ATM ATM DNA repair, damage; EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, Ser/Thr (non-receptor); Protein kinase, atypical; Tumor suppressor Q13315 472 11q22.3 human S2996-p 7433302 QECKRNLsDIDQSFN enzymatic activity, induced carcinogenesis, induced; DNA repair, induced 21149446; 33568520 4 12 0 +POLH POLH DNA repair, damage; EC 2.7.7.7; Transferase Q9Y253 5429 6p21.1 human K494-sm 1877365909 AAERQKVkEASLSSL intracellular localization; enzymatic activity, inhibited 32350109 1 1 0 +GPS2 GPS2 Cell cycle regulation; G protein regulator, misc.; Inhibitor; Nuclear receptor co-regulator; Transcription, coactivator/corepressor Q13227 2874 17p13.1 human R323-m1 11263012 IQHSQNPrFYHK___ molecular association, regulation HLAA(INDUCES) 19917673 1 1 0 there were no differences in binding of unmethylated, mono-methylated, or di-methylated peptides +LDLRAP1 LDLRAP1 Q5SW96 26119 1p36.11 human S14-p 3198716 AGRALIRsPSLAKQS cell cycle regulation 21778424 1 24 6 +Elk4 ELK4 DNA-binding; Transcription, coactivator/corepressor P41158 13714 1|1 E4 mouse S386-p 4317601 LSPFAPLsPARLQGA cell growth, altered 18356083 3 0 0 pro-B cell expansion +CTNNB1 CTNNB1 Actin-binding; Cell adhesion; Motility/polarity/chemotaxis; Nuclear receptor co-regulator; Oncoprotein; Transcription factor P35222 1499 3p22.1 human S45-p 447488 GATTTAPsLSGKGNP protein degradation; protein stabilization; molecular association, regulation; activity, inhibited; phosphorylation; ubiquitination; intracellular localization; neddylation cell cycle regulation; carcinogenesis, induced; carcinogenesis, altered; carcinogenesis, inhibited; cell growth, inhibited; transcription, induced; signaling pathway regulation; cell differentiation, induced; cell motility, altered; cell adhesion, altered; transcription, inhibited CBLL1(INDUCES); axin 1(INDUCES); TRAF2(DISRUPTS); CDH1(INDUCES); RNF4(INDUCES) 11955436; 12000790; 16618120; 18356165; 19244247; 20419129; 25660024; 27653698; 31462704; 31933784; 32021251; 32041324; 32046730; 33832512; 34117362; 34657130; 35108540; 35320710; 35358275; 35879396; 36808719 57 7 0 +Slc1a2 GLT1 Membrane protein, integral; Membrane protein, multi-pass; Transporter; Transporter, SLC family P31596 29482 3q32 rat K573-ub 1873542800 EEPWKREk_______ receptor internalization, induced; protein degradation 18805448 1 0 0 +E2F1 E2F1 DNA-binding; Transcription factor Q01094 1869 20q11.22 human S364-p 449403 PLLSRMGsLRAPVDE activity, induced; protein degradation; molecular association, regulation; protein stabilization; intracellular localization; enzymatic activity, induced cell cycle regulation; carcinogenesis, induced; cell growth, inhibited; apoptosis, induced; autophagy, inhibited; transcription, induced; signaling pathway regulation Rb(INDUCES) 12717439; 22184068; 33110360; 33174204; 35301407 8 2 0 +CEBPD C/EBP-delta DNA-binding; Motility/polarity/chemotaxis P49716 1052 8q11.21 human S57-p 40263800 PAMYDDEsAIDFSAY enzymatic activity, induced transcription, induced 25680545 1 0 0 activates PPARgamma2 promoter +Stk3 MST2 Autophagy; EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, STE; Protein kinase, Ser/Thr (non-receptor) Q9JI10 56274 15|15 B3.1 mouse Y81-p 25528501 MQQCDSPyVVKYYGS Pkinase molecular association, regulation apoptosis, induced MST2(INDUCES); RAF1(DISRUPTS) 22590567 1 1 0 +CERS4 LASS4 DNA-binding; Membrane protein, integral; Membrane protein, multi-pass Q9HA82 79603 19p13.2 human S349-p 7102761 SDVEESDsSEEAAAA enzymatic activity, induced 26887952 1 7 0 +DEPTOR DEPTOR Apoptosis Q8TB45 64798 8q24.12 human T241-p 4723803 KSPSSQEtHDSPFCL protein degradation; molecular association, regulation carcinogenesis, induced; apoptosis, inhibited; signaling pathway regulation mTOR(DISRUPTS) 19446321 1 4 2 PI3K-Akt signaling +AXIN1 axin 1 Adaptor/scaffold; Tumor suppressor O15169 8312 16p13.3 human S77-p 3174926 YEPEGSAsPTPPYLK AXIN1_TNKS_BD transcription, inhibited GSK3B(INDUCES) 17318175 1 13 9 +CLCN1 CLCN1 Channel, chloride; Membrane protein, integral; Membrane protein, multi-pass; Transporter; Transporter, ion channel P35523 1180 7q34 human T893-p 14645301 SFRNTTStRKSTGAP activity, induced 20511714 1 0 1 +TRAF3 TRAF3 UBIQUITIN LIGASE; Ubiquitin conjugating system; Ubiquitin ligase Q13114 7187 14q32.32 human K168-ub 56836807 DLRDHVEkACKYREA zf-TRAF molecular association, regulation exocytosis, induced RALGDS(INDUCES) 27438768 1 0 0 K33 polyubiquitination of TRAF3 Is necessary for RALGDS binding; exocytosis of bacteria via TLR4-mediated innate immune signaling +Pxn PXN Adaptor/scaffold; Cell adhesion; Cytoskeletal; Motility/polarity/chemotaxis Q8VI36 19303 5 F|5 56.1 cM mouse S83-p 451113 YAHQQPPsPLPVYSS Paxillin activity, induced; molecular association, regulation cell differentiation, altered; cell motility, altered; cytoskeletal reorganization ERK1(INDUCES); FAK iso2(INDUCES) 15494312 7 40 44 +Plcg1 PLCG1 Carbohydrate Metabolism - inositol phosphate; EC 3.1.4.11; Motility/polarity/chemotaxis; Phospholipase P10686 25738 3q42 rat Y509-p 464036 NHEWYPHyFVLTSSK enzymatic activity, inhibited; phosphorylation 20164676 3 0 8 Y509A/F510A mutant PLCG1 has enhanced phosphorylation of Y783, but no longer requires Y783 phosphorylation for enzymatic activation +MAPK11 P38B EC 2.7.11.24; KINASE; Kinase, protein; Protein kinase, CMGC; Protein kinase, Ser/Thr (non-receptor) Q15759 5600 22q13.33 human S261-p 54390601 HARTYIQsLPPMPQK Pkinase enzymatic activity, inhibited 26976637 1 1 0 +NUP98 NUP98 iso2 Motility/polarity/chemotaxis; Nucleoporin P52948-2 4928 11p15.4 human S591-p 470431 VLKNLNNsNLFSPVN intracellular localization 21335236 1 35 2 as multiple sites (13PM) mutant +EEF1D EEF1D Translation; Translation elongation P29692 1936 8q24.3 human S133-p 455672 APQTQHVsPMRQVEP phosphorylation 12551973 2 108 49 +FOXO3 FOXO3A Autophagy; DNA-binding; Oncoprotein; Transcription factor O43524 2309 6q21 human S294-p 472326 QLSKWPGsPTSRSSD protein degradation; molecular association, regulation; activity, inhibited cell growth, altered MDM2(INDUCES) 18204439 5 19 63 promotes tumorigenicity +Med1 MED1 Nuclear receptor co-regulator; Transcription, coactivator/corepressor Q925J9 19014 11 D|11 61.75 cM mouse T1032-p 458308 SSSNRPFtPPTSTGG transcription, induced 18339625 4 8 2 +NEDD8 NEDD8 Ubiquitin-like modifier Q15843 4738 14q12 human K48-ac 461330 QRLIYSGkQMNDEKT ubiquitin molecular association, regulation PARP1(INDUCES) 30804002 1 6 3 +SKP2 SKP2 Cell cycle regulation; UBIQUITIN LIGASE; Ubiquitin conjugating system; Ubiquitin ligase Q13309 6502 5p13.2 human K68-ac 25673101 HPESPPRkRLKSKGS protein stabilization; intracellular localization carcinogenesis, induced; cell motility, induced SKP2(INDUCES) 22770219; 23230084 2 1 0 +Ppara PPAR-alpha DNA-binding; Nuclear receptor; UBIQUITIN LIGASE P37230 25747 7q34 rat S163-p 22342300 CRFHKCLsVGMSHNA zf-C4 intracellular localization transcription, induced 22091731 1 0 0 +Foxo1 FOXO1A DNA-binding; Nuclear receptor co-regulator; Oncoprotein; Transcription factor Q9R1E0 56458 3 C|3 23.19 cM mouse S415-p 478369 NTSLNSPsPNYSKYT molecular association, regulation; intracellular localization transcription, inhibited DUSP6(INDUCES) 22503562; 22848439 4 1 0 +CASQ2 calsequestrin 2 Calcium-binding P12637 483134 dog S397-p 451464 DDDDGNNsDEESNDD intracellular localization 21431367 2 3 0 regulates intracellular trafficking of calsequestrin 2 +Aqp2 AQP2 Channel, misc.; Membrane protein, integral; Membrane protein, multi-pass; Transporter; Transporter, aquaporin family P34080 25386 7q36 rat S269-p 3339002 PQSLPRGsKA_____ intracellular localization endocytosis, inhibited 18843259; 20089674; 22403603; 23559583; 26147297; 30488437; 32113684 37 5 0 +PRKCA PKCA EC 2.7.11.13; KINASE; Kinase, protein; Oncoprotein; Protein kinase, AGC; Protein kinase, Ser/Thr (non-receptor) P17252 5578 17q24.2 human T228-p 3875546 PQWNESFtFKLKPSD C2 molecular association, regulation; enzymatic activity, induced RhoGDI beta(INDUCES) 26414765 1 5 13 +KEAP1 KEAP1 Endoplasmic reticulum; Motility/polarity/chemotaxis; Transcription regulation; UBIQUITIN LIGASE; Ubiquitin conjugating system Q14145 9817 19p13.2 human S599-p 29606702 SEVTRMTsGRSGVGV molecular association, regulation carcinogenesis, inhibited; apoptosis, inhibited NRF2(INDUCES) 24127568 1 1 0 +UNG UNG EC 3.2.2.27; Hydrolase P13051 7374 12q24.11 human S23-p 2018600 ARKRHAPsPEPAVQG activity, induced; molecular association, regulation; enzymatic activity, induced RPA1(INDUCES) DNA(INDUCES) 18079698 1 34 1 +Nr2c1 NR2C1 DNA-binding; Nuclear receptor Q505F1 22025 10 C2|10 48.81 cM mouse S185-p 457682 IEVSREKsSNCAAST molecular association, regulation PCAF(INDUCES) 16317770 1 0 0 this interaction is enhanced by S170 phosphorylation +MITF MITF iso9 DNA-binding; Oncoprotein; Transcription factor O75030-9 4286 3p13 human K316-sm 3590700 DLVNRIIkQEPVLEN DUF3371 transcription, inhibited 15507434 3 1 0 +PLCG2 PLCG2 Carbohydrate Metabolism - inositol phosphate; EC 3.1.4.11; Motility/polarity/chemotaxis; Phospholipase P16885 5336 16q23.3 human Y1197-p 447938 LESEEELySSCRQLR enzymatic activity, induced 30344948 4 1 87 intramolecular tyrosine-phosphorylation and Rac mediated activation +Panx1 PANX1 Cell adhesion; Membrane protein, integral; Membrane protein, multi-pass Q9JIP4 55991 9|9 A2 mouse S205-p 1874115103 YLKTKKNsSHLIMKY Innexin activity, induced 34283971 1 0 0 +SNCA SNCA Adaptor/scaffold P37840 6622 4q22.1 human K21-ub 466355 GVVAAAEkTKQGVAE Synuclein ubiquitination; phosphorylation 16847063 1 1 0 SNCA is phosphorylated, truncated, and then deposited to Lewy bodies.and then ubiquitinated which occurs at K12, K21. and K23 +Glra3 GLRA3 Membrane protein, integral; Membrane protein, multi-pass; Transporter; Transporter, ion channel Q91XP5 110304 8 B2|8 29.69 cM mouse S379-p 1848000 TDDEVREsRFSFTAY Neur_chan_memb receptor desensitization, altered; activity, inhibited 17997221 2 0 0 +RPAP3 RPAP3 Unknown function Q9H6T3 79657 12q13.11 human S119-p 1279822 HESLSQEsESEEDGI molecular association, regulation 35129352 1 26 9 inhibits binding to ribosomal proteins and biogenesis factors associated with small (40S) and large (60S) subunits of the ribosome +H3C14 HIST2H3A/C/D DNA-binding Q71DI3 126961 1q21.2 human S10-p 18465104 TKQTARKsTGGKAPR Histone chromatin organization, altered; transcription, induced 20075197 1 2 0 +AKT1 Akt1 EC 2.7.11.1; KINASE; Kinase, protein; Oncoprotein; Protein kinase, AGC; Protein kinase, Ser/Thr (non-receptor) P31749 207 14q32.33 human K284-ub 964497186 LENLMLDkDGHIKIT Pkinase protein degradation; molecular association, regulation autophagy, induced GRP78(INDUCES) 32164484 2 1 0 HSPA5 arginylation, modulated by ATE1 +FOXL2 FOXL2 DNA-binding; Transcription factor P58012 668 3q22.3 human K25-sm 10304922 PETGRTVkEPEGPPP transcription, inhibited 19744555 1 0 0 +NDUFS2 NDUFS2 EC 1.6.5.3; EC 1.6.99.3; Energy Metabolism - oxidative phosphorylation; Mitochondrial; Oxidoreductase O75306 4720 1q23.3 human S364-p 33402201 KVDDAKVsPPKRAEM Complex1_49kDa activity, induced cell cycle regulation 24746669 1 1 0 increases mitochondrial respiration for G/2M transition +Ppp1r12a MYPT1 Motility/polarity/chemotaxis; PHOSPHATASE; Protein phosphatase, regulatory subunit Q9DBR7 17931 10 D1|10 56.33 cM mouse S909-p 1983104 SLLGRSAsYSYLEDR molecular association, regulation 14-3-3 zeta(INDUCES) 26702834 3 43 60 +Esrra ERR1 DNA-binding; Nuclear receptor; Transcription regulation O08580 26379 19 A|19 5.08 cM mouse K402-sm 487494 LAHFYGVkLEGKVPM Hormone_recep transcription, inhibited 18063693 2 1 0 +PRKDC DNAPK DNA repair, damage; EC 2.7.11.1; KINASE; Kinase, protein; Nucleolus; Protein kinase, Ser/Thr (non-receptor); Protein kinase, atypical P78527 5591 8q11.21 human T2620-p 473574 QGTLQTRtQEGSLSA DNAPKcs_CC5 molecular association, regulation; protein conformation DNA repair, induced DNA(DISRUPTS) 24687855 2 4 17 cell survival induced, induces removal of cisplatin adducts from DNA, induces end processing +ERBB4 HER4 EC 2.7.10.1; KINASE; Kinase, protein; Membrane protein, integral; Protein kinase, TK; Protein kinase, tyrosine (receptor) Q15303 2066 2q34 human Y1081-p 4825103 EQGVSVPyRAPTSTI molecular association, regulation Arg(INDUCES); CRK(INDUCES) 18721752 0 1 0 +Bcl11b Bcl-11B C2H2-type zinc finger protein; Nuclear receptor co-regulator; Transcription regulation Q99PV8 58208 12 F1|12 59.1 cM mouse T260-p 3828640 GPASTSLtPRLTIPP molecular association, regulation SENP1(INDUCES) 22700985 0 6 52 +TWIST1 TWIST1 Cell development/differentiation; DNA-binding; Inhibitor; Transcription regulation Q15672 7291 7p21.1 human K33-me 1883454506 RQQPPSGkRGGRKRR cell motility, induced; transcription, inhibited; cell adhesion, inhibited 35694846 1 1 0 methylation of TWIST1 at K33 represses the expression of LINC-PINT by increasing H3K27me3 repressive mark at the LINC-PINT locus +SNCA SNCA Adaptor/scaffold P37840 6622 4q22.1 human K58-ub 1877722302 GVATVAEkTKEQVTN Synuclein protein degradation; ubiquitination 31167929 1 1 0 ubiquitination and degradation of internalized SNCA fibrils +ZNF322 ZNF322A C2H2-type zinc finger protein; Transcription factor Q6U7Q0 79692 6p22.2 human S224-p 114810402 EKSYRHRsAFIVHKR zf-C2H2 activity, induced; molecular association, regulation carcinogenesis, induced; chromatin organization, altered; cell motility, induced; cell growth, induced; transcription, induced DNA(INDUCES) 31399647 2 1 0 chromatin binding; increases recruitment to ADD1 and CCND1 promoters +NEDD1 NEDD1 Cell cycle regulation Q8NHV4 121441 12q23.1 human S558-p 25533010 PNPKIASsVTAGVAS molecular association, regulation cytoskeletal reorganization TUBG1(INDUCES) 22595525 1 1 0 regulates spindle assembly in mitosis; Negative effect on NEDD1 function +ARID5B Mrf-2 Q14865 84159 10q21.2 human K336-m2 20936502 YKYMKERkTPIERIP ARID molecular association, regulation transcription, induced Mrf-2(INDUCES) DNA(INDUCES) 21532585 1 0 0 demethylation of Mrf-2 K336, complex is then targeted to promoters and removes repressive H3K9m2 +RPS6KA6 RSK4 EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, AGC; Protein kinase, Ser/Thr (non-receptor) Q9UK32 27330 Xq21.1 human S232-p 457600 DQEKKAYsFCGTVEY Pkinase protein conformation; enzymatic activity, induced carcinogenesis, induced; cell motility, induced 15632195; 34261798 2 40 151 +STX17 STX17 Membrane protein, integral; Membrane protein, multi-pass; Vesicle P56962 55014 9q31.1 human S2-p 50800659 ______MsEDEEKVK molecular association, regulation autophagy, inhibited; signaling pathway regulation VPS33A(INDUCES); VAMP7(DISRUPTS); SNAP29(DISRUPTS) 30655294 1 1 0 +KIF2C KIF2C Cancer Testis Antigen (CTA); Microtubule-binding; Motility/polarity/chemotaxis; Motor Q99661 11004 1p34.1 human S115-p 2132104 RSRSTRMsTVSELRI intracellular localization; activity, inhibited cytoskeletal reorganization 14960279 1 8 8 +Ctnnb1 CTNNB1 Actin-binding; Cell adhesion; Motility/polarity/chemotaxis; Nuclear receptor co-regulator; Oncoprotein; Transcription factor Q02248 12387 9 F4|9 72.19 cM mouse Y654-p 447585 RNEGVATyAAAVLFR activity, induced; molecular association, regulation; intracellular localization carcinogenesis, induced; cell motility, altered; transcription, induced; cell adhesion, altered; cytoskeletal reorganization; transcription, altered TCF4(INDUCES); TBP(INDUCES); CDH2(DISRUPTS); CDH1(DISRUPTS); SMAD2(INDUCES) 10593980; 11279024; 19104148; 19336574; 22203675; 28821617; 33929542; 37029299 32 2 20 +CCNY CBCP1 Cell cycle regulation Q8ND76 219771 10p11.21 human S73-p 3850500 STIFLSKsQTDVREK protein degradation; ubiquitination 24794231 1 19 49 +Gab2 GAB2 Adaptor/scaffold Q9Z1S8 14389 7|7 E1 mouse S620-p 15410336 PSPHRKPsTSSVTSD molecular association, regulation; phosphorylation cell motility, inhibited; signaling pathway regulation SHP-2(DISRUPTS) 23401857 1 1 2 inhibits ERK1/2 phosphorylation, modulates Ras/MAPK signaling pathway +ARHGEF7 ARHGEF7 iso1 GEF; GEF, Rac/Rho; Motility/polarity/chemotaxis Q14155-1 8874 13q34 human S340-p 454356 LSASPRMsGFIYQGK PH activity, induced; molecular association, regulation RAC1(INDUCES) 24792722 2 102 7 O2 production increased, Nox1 activity upregulated +HMGB1 HMGB1 DNA repair, damage; Nuclear receptor co-regulator P09429 3146 13q12.3 human S39-p 7320388 PDASVNFsEFSKKCS HMG_box_2 intracellular localization cell motility, altered 19506549; 22750245; 23782844 4 5 2 increases tumor cell invasiveness +Rps6kb1 p70S6K EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, AGC; Protein kinase, Ser/Thr (non-receptor); Translation Q8BSK8 72508 11|11 C mouse T412-p 448607 NQVFLGFtYVAPSVL Pkinase_C molecular association, regulation; ubiquitination; enzymatic activity, induced cell cycle regulation; carcinogenesis, induced; carcinogenesis, inhibited; apoptosis, induced; translation, induced; signaling pathway regulation DEDD(INDUCES) 17562705; 18851840; 19106089; 20657550; 25119572; 25680463; 33567340; 33826903; 33876772; 34531315; 34664403; 36012713 476 9 1 +SCN5A SCN5A Channel, sodium; Membrane protein, integral; Membrane protein, multi-pass Q14524 6331 3p22.2 human S571-p 27281507 PWPLRRTsAQGQPSP Na_trans_cytopl activity, induced; intracellular localization; enzymatic activity, induced 30385719; 31622781 10 4 0 Induce and regulate Atrial fibrillation, increase calcium mediated arrhythmia and regulates atrial myocyte late Na current and membrane excitability; triggered Ca2+ waves +LCK Lck EC 2.7.10.2; KINASE; Kinase, protein; Oncoprotein; Protein kinase, TK; Protein kinase, tyrosine (non-receptor) P06239 3932 1p35.2 human S59-p 447820 EGSNPPAsPLQDNLV molecular association, regulation; enzymatic activity, inhibited cell adhesion, inhibited SQSTM1(INDUCES) 27941787; 7597029; 8618896 10 2 7 +MALT1 MALT1 Adaptor/scaffold; Apoptosis; EC 3.4.22.-; Ligase; Nuclear export; Protease; UBIQUITIN LIGASE; Ubiquitin conjugating system Q9UDY8 10892 18q21.32 human K702-ub 2134709 LEDTVEDkQEVNVGK MALT1_Ig protein degradation; molecular association, regulation IKKA(INDUCES) 17948050 1 0 0 activation of NF-kB pathway and IL-2 induction +Fos Fos DNA-binding; Motility/polarity/chemotaxis; Oncoprotein; Transcription factor P01101 14281 12 D2|12 39.7 cM mouse S362-p 448481 AAAHRKGsSSNEPSS activity, induced; molecular association, regulation; protein stabilization carcinogenesis, induced; transcription, altered; signaling pathway regulation ER-beta(INDUCES) 15719069; 21119595; 21565615 10 3 1 c-FOS transcription inhibited +IKBKG IKKG Adaptor/scaffold; Protein kinase, regulatory subunit Q9Y6K9 8517 Xq28 human K285-ub 486356 QEVIDKLkEEAEQHK CC2-LZ activity, induced; ubiquitination apoptosis, inhibited; transcription, induced; signaling pathway regulation 15620648; 17728323; 19136968; 20932475; 21811235; 23453807; 23871670 7 7 12 regulates NF-kB ignaling and mitochondrial integrity; Loss of LUBAC impaired TNF mediated NF-kB activation, HOIL-1 deficiency (ubiquitylation) enhances apoptosis; activation of TAK1 IKK and NF-kB after genotoxic stress; K-R mutants cause embryonic lethality, complemented by TNFR1 loss, regulates NF-kB activation and NOD2 signaling in response to innate immune agonists +TRDMT1 TRDMT1 Amino Acid Metabolism - cysteine and methionine; EC 2.1.1.204; METHYLTRANSFERASE; Methyltransferase; Methyltransferase, tRNA O14717 1787 10p13 human K251-ub 1881202800 QDSDLSVkMLKDFLE DNA repair, inhibited 33778494 1 1 0 role in removing TRDMT1 from DNA damage sites after completion of repair +Gsk3a GSK3A EC 2.7.11.1; EC 2.7.11.26; KINASE; Kinase, protein; Protein kinase, CMGC; Protein kinase, Ser/Thr (non-receptor) Q2NL51 606496 7|7 A3 mouse S21-p 448584 SGRARTSsFAEPGGG protein degradation; enzymatic activity, inhibited; phosphorylation cell motility, induced; apoptosis, induced; cell adhesion, inhibited; transcription, altered; signaling pathway regulation; cytoskeletal reorganization; cell growth, altered; endocytosis, inhibited 15033922; 15791206; 18851840; 19106302; 22172670; 34638997; 36445308 156 24 277 inhibits DYN2 phosphorylation; regulate platelet activation +Srebf1 SREBP-1 iso1 DNA-binding; Membrane protein, integral; Membrane protein, multi-pass; Transcription factor P56720-1 78968 10q22 rat S308-p 458357 IEKRYRSsINDKIVE HLH sumoylation; protein degradation; ubiquitination transcription, inhibited 24379443; 24853806 4 1 0 +Enah Mena iso4 Adaptor/scaffold; Motility/polarity/chemotaxis Q03173-4 13800 1 H5|1 84.93 cM mouse S236-p 451465 WERERRMsNAAPSSD cell motility, altered; cytoskeletal reorganization; cell growth, altered 12134088; 15066263 3 2 15 +TTK TTK Cancer Testis Antigen (CTA); EC 2.7.12.1; KINASE; Kinase, protein; Protein kinase, Other; Protein kinase, dual-specificity (non-receptor) P33981 7272 6q14.1 human K367-sm 52485002 TESSLLAkLEETKEY molecular association, regulation cell cycle regulation BUB1B(DISRUPTS) 26675261 1 1 0 +WASF3 WASF3 Actin-binding; Motility/polarity/chemotaxis Q9UPY6 10810 13q12.13 human Y151-p 486448 KKDGLKFyTDPSYFF cell motility, induced; cytoskeletal reorganization 17623672 1 0 0 induces lamellipodia formation +Akt1 Akt1 EC 2.7.11.1; KINASE; Kinase, protein; Oncoprotein; Protein kinase, AGC; Protein kinase, Ser/Thr (non-receptor) P47196 24185 6q32 rat S473-p 447855 RPHFPQFsYSASGTA Pkinase_C activity, induced; molecular association, regulation; intracellular localization; protein conformation; phosphorylation; enzymatic activity, induced cell cycle regulation; cell differentiation, altered; autophagy, induced; cell growth, induced; cell adhesion, induced; apoptosis, inhibited; signaling pathway regulation RAF1(INDUCES) 11027222; 11042116; 11443134; 11517188; 14627993; 15665834; 15853465; 16829026; 17079231; 18838385; 19757038; 20096547; 21736902; 21949366; 22031698; 22046442; 22228770; 33864097; 34057658; 34221817; 34335915; 34475824; 34577062; 35562960; 37237886 1956 25 44 +App APP Apoptosis; Cell surface; Membrane protein, integral; Receptor, misc.; Transcription factor P08592 54226 11q11 rat T743-p 448523 VEVDAAVtPEERHLS APP_amyloid protein degradation 14557249 39 5 3 T743 phosphorylation directly impacts on APP cleavage +OTUD6A OTUD6A DEUBIQUITINASE; EC 3.4.19.12; Ubiquitin-specific protease Q7L8S5 139562 Xq13.1 human S71-p 40512705 EKFQDDSsIESVVED molecular association, regulation; intracellular localization cell cycle regulation; carcinogenesis, induced TOPBP1(DISRUPTS) 35768646 1 3 0 +DYNLL1 LC8 Microtubule-binding; Motility/polarity/chemotaxis; Motor P63167 8655 12q24.31 human S88-p 454241 VAILLFKsG______ Dynein_light molecular association, regulation; protein conformation; phosphorylation cell cycle regulation; cell differentiation, altered; apoptosis, altered; apoptosis, inhibited; cell growth, altered LC8(DISRUPTS); PAK1(DISRUPTS); MRE11A(INDUCES); 53BP1(DISRUPTS); BLM(INDUCES); NBS1(INDUCES); DNA2(INDUCES); RAD50(INDUCES); BIM(DISRUPTS) 15193260; 18084006; 18650427; 19289209; 19863079; 21062069; 23038268; 30464262 9 0 0 +RPS3 RPS3 Apoptosis; EC 4.2.99.18; RNA-binding; Ribosomal; Translation P23396 6188 11q13.4 human K230-sm 25218901 ISEQKGGkPEPPAMP protein stabilization 21968017 1 3 0 +PUM3 PUM3 Endoplasmic reticulum; Nucleolus; RNA-binding Q15397 9933 9p24.2 human Y259-p 463700 SAIVEYAyNDKAILE protein stabilization; ubiquitination; intracellular localization carcinogenesis, induced; cell growth, induced 34407138 1 5 70 inhibits ubiquitination +CGAS cGAS EC 2.7.7.86 Q8N884 115004 6q13 human K384-ac 14366387 LSFSHIEkEILNNHG Mab-21 enzymatic activity, inhibited; protein conformation; activity, inhibited apoptosis, inhibited 30799039; 32345711; 33438687 3 3 0 +JAK1 JAK1 EC 2.7.10.2; KINASE; Kinase, protein; Protein kinase, TK; Protein kinase, tyrosine (non-receptor) P23458 3716 1p31.3 human Y1034-p 448451 AIETDKEyYTVKDDR PK_Tyr_Ser-Thr enzymatic activity, induced carcinogenesis, induced; cell motility, induced 32029900; 34380633; 36166512 33 12 178 +FXYD1 PLM Cell surface; Channel, misc.; Membrane protein, integral P56513 476487 dog S88-p 451425 RSSIRRLsTRRR___ activity, induced 15653756; 17991751 27 3 74 increases Na(+) affinity of ATP1A1/B1; regulation of cardiac contractility +H1-4 H1E DNA-binding P10412 3008 6p22.2 human K26-m3 6742809 PVKKKARkSAGAAKR cell cycle regulation 24873882 2 1 0 +LMNB1 Lamin B1 Cytoskeletal P20700 4001 5q23.2 human K134-ac 33363078 DLNGAQIkLREYEAA Filament protein stabilization cell cycle regulation; DNA repair, inhibited 33533922 1 3 0 K134 acetylation may stabilize LMNB1, maintaining nuclear periphery integrity during viral infections, impacts G1 to S phase cell cycle transition, reduces laminar association with chromatin, delays recruitment of cNHEJ repair factor 53BP1 to DNA repair foci +AIP AIP Nuclear receptor co-regulator; Transcription, coactivator/corepressor O00170 9049 11q13.2 human S53-p 10888703 EGTVLDDsRARGKPM FKBP_C intracellular localization 12361709 1 0 0 +SHC1 SHC1 Adaptor/scaffold; Apoptosis; Mitochondrial; Motility/polarity/chemotaxis P29353 6464 1q21.3 human Y349-p 448509 EEPPDHQyYNDFPGK molecular association, regulation apoptosis, altered; apoptosis, inhibited GRB2(INDUCES) 15688026; 8939605; 8947042 32 22 947 +CYLD CYLD DEUBIQUITINASE; EC 3.4.19.12; Protease; Tumor suppressor; Ubiquitin conjugating system; Ubiquitin-specific protease Q9NQC7 1540 16q12.1 human S362-p 31957307 FYTLNGSsVDSQPQS CYLD_phos_site enzymatic activity, induced 24614225 1 1 0 +PRRG4 PRRG4 Membrane protein, integral Q9BZD6 79056 11p13 human Y207-p 1870790706 SVSPPPPyPGHTKGF molecular association, regulation; phosphorylation carcinogenesis, induced; cell motility, induced Src(INDUCES); NEDD4(INDUCES) 33037408 1 0 0 FAK phosphorylation +RRAD RRAD G protein; G protein, monomeric; G protein, monomeric, RGK P55042 6236 16q22.1 human S290-p 457397 GRIVARNsRKMAFRA molecular association, regulation Calmodulin(INDUCES) 9677319 1 1 0 +CALD1 Caldesmon Actin-binding P12957 373965 chicken S602-p 457430 CFSPKGSsLKIEERA Caldesmon molecular association, regulation ACTB(NOT_REPORTED) 8182108 2 9 0 +CDX2 CDX2 DNA-binding; Transcription factor Q99626 1045 13q12.2 human S283-p 456208 RSVPEPLsPVSSLQA protein degradation 16027724 1 1 0 +MRE11 MRE11A Cell cycle regulation; DNA repair, damage; DNA-binding; Deoxyribonuclease P49959 4361 11q21 human R577-me 2344808 RGRGRGRrGGRGQNS intracellular localization 15970667 1 0 0 localizes in nucleus and associates with nuclear bodies and sites of DNA damage +CDK1 CDK1 Cell cycle regulation; EC 2.7.11.22; EC 2.7.11.23; KINASE; Kinase, protein; Motility/polarity/chemotaxis; Protein kinase, CMGC; Protein kinase, Ser/Thr (non-receptor) P06493 983 10q21.2 human T161-p 447609 GIPIRVYtHEVVTLW Pkinase molecular association, regulation; intracellular localization; enzymatic activity, induced cell cycle regulation; carcinogenesis, induced; apoptosis, induced; cell growth, induced; cell growth, altered CCNB1(INDUCES); CCNA2(INDUCES) 12663041; 1532335; 1833185; 21900495; 25849598; 31429764; 33574676; 34064109; 34370741; 35392228; 36163549; 36967563; 8441405 44 43 83 +Stx3 STX3 Cell adhesion; Membrane protein, integral; Vesicle Q08849 81802 1q43 rat T14-p 31960301 QLKAKQLtQDDDTDE molecular association, regulation; protein conformation exocytosis, inhibited STXBP2(DISRUPTS) 26936588 5 1 0 degranulation decreased +PRKCD PKCD EC 2.7.11.13; KINASE; Kinase, protein; Nuclear receptor co-regulator; Protein kinase, AGC; Protein kinase, Ser/Thr (non-receptor); Protein kinase, tyrosine (non-receptor); Tumor suppressor Q05655 5580 3p21.1 human Y52-p 447574 VQKKPTMyPEWKSTF activity, inhibited apoptosis, altered 11927579 4 0 0 +Msn Moesin Cytoskeletal; Motility/polarity/chemotaxis P26041 17698 X|X C3 mouse T558-p 447706 LGRDKYKtLRQIRQG ERM_C molecular association, regulation; intracellular localization cell motility, altered; cytoskeletal reorganization Moesin(INDUCES) 19255442; 19890007; 24250818; 9456324; 9856983 40 8 29 iincreased filopodia with phosphorylated ERM proteins +Abl2 Arg EC 2.7.10.2; KINASE; Kinase, protein; Oncoprotein; Protein kinase, TK; Protein kinase, tyrosine (non-receptor) Q4JIM5 11352 1 G3|1 67.71 cM mouse Y272-p 456540 KCNKPTVyGVSPIHD enzymatic activity, induced 12748290 3 5 3 +GIT1 GIT1 iso3 GAP; GAP, ARF; Motility/polarity/chemotaxis Q9Y2X7-3 28964 17q11.2 human T765-p 1868139202 KQLVTITtREKKQ__ GIT1_C molecular association, regulation liprin alpha 1(DISRUPTS); PXN(INDUCES) 30737283 1 0 0 +SCN5A SCN5A Channel, sodium; Membrane protein, integral; Membrane protein, multi-pass Q14524 6331 3p22.2 human T486-p 7835300 RKRMSSGtEECGEDR protein conformation 33410863 2 4 2 +CHEK2 Chk2 EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, CAMK; Protein kinase, Ser/Thr (non-receptor); Tumor suppressor O96017 11200 22q12.1 human S19-p 447546 SHGSSACsQPHGSVT molecular association, regulation; enzymatic activity, induced cell cycle regulation Chk2(INDUCES) 16940182 12 1 0 S19A mutant shows impaired dimerization and does not promote Hdmx degradation +MAPT Tau iso8 ACETYLTRANSFERASE; Acetyltransferase; Cytoskeletal P10636-8 4137 17q21.31 human K321-ac 490850600 DLSKVTSkCGSLGNI Tubulin-binding molecular association, regulation; acetylation; protein conformation cytoskeletal reorganization 28760828; 34426645 2 1 0 impedes tau filament assembly ; acetylation mimetics are aggregation resistant, inhibit prion-like seeded P301L mutation aggregation, alter conformation of P301L/S320F aggregation; reduced tau microtuble interactions +ALYREF THOC4 Chaperone; RNA-binding; Spliceosome; Transcription, coactivator/corepressor Q86V81 10189 17q25.3 human T219-p 4614100 GGGTRRGtRGGARGR FoP_duplication activity, induced cell growth, altered 18562279 1 1 0 required for THOC4 mRNA export activity +ADORA2A ADORA2A GPCR, family 1; Membrane protein, integral; Membrane protein, multi-pass; Receptor, GPCR P11617 403960 dog T298-p 451126 RIREFRQtFRKIIRS receptor desensitization, altered 9020781 1 0 0 The integrity of T298 is essential for short-term but not long-term desensitization of A2aAR function. +CYSLTR1 CYSLTR1 GPCR, family 1; Membrane protein, integral; Membrane protein, multi-pass; Receptor, GPCR Q9Y271 10800 Xq21.1 human S313-p 11143517 LSTFRKHsLSSVTYV receptor desensitization, induced transcription, induced 22230957 1 3 3 +Smad1 SMAD1 DNA-binding; Transcription factor P97588 25671 19q11 rat S466-p 448362 SPHNPISsVS_____ cell growth, induced; signaling pathway regulation 21445358 12 13 58 Src/SMAD1 signaling pathway +Ctnnb1 CTNNB1 Actin-binding; Cell adhesion; Motility/polarity/chemotaxis; Nuclear receptor co-regulator; Oncoprotein; Transcription factor Q9WU82 84353 8q32 rat Y142-p 449044 AVVNLINyQDDAELA intracellular localization 33660049 16 2 0 regulates dissociation of adherent junctions +HSD17B10 HADH2 Amino Acid Metabolism - valine, leucine and isoleucine degradation; EC 1.1.1.178; EC 1.1.1.35; EC 1.1.1.51; Mitochondrial; Oxidoreductase Q99714 3028 Xp11.22 human K79-ac 33345847 QTALALAkGKFGRVD adh_short enzymatic activity, inhibited cell growth, inhibited RG9MTD1(DISRUPTS) 32703935; 32956445 2 3 0 formation of mt-tRNA splicing complex, regulated mitochondrial function, les cell resistance to stress and cell growth ; mt-tRNA splicing complex +RB1 Rb Nuclear receptor co-regulator; Oncoprotein; Transcription, coactivator/corepressor; Tumor suppressor P06400 5925 13q14.2 human S795-p 447979 SPYKFPSsPLRIPGG Rb_C molecular association, regulation; activity, inhibited cell cycle regulation; carcinogenesis, induced; cell growth, induced; cell growth, altered ARF1(DISRUPTS); E2F1(DISRUPTS); TFDP1(DISRUPTS) 14676836; 15028555; 15619620; 16007177; 16360038; 21478909; 33931028; 9190208; 9315635 52 17 94 +Sirt7 SIRT7 DEACETYLASE; Deacetylase; EC 3.5.1.-; Nucleolus Q8BKJ9 209011 11|11 E2 mouse T256-p 1874512902 PLNWEAAtEAASKAD SIR2 protein stabilization; molecular association, regulation; ubiquitination; phosphorylation carcinogenesis, inhibited; cell motility, inhibited; transcription, inhibited; signaling pathway regulation UBR5(DISRUPTS); SKP2(INDUCES) 34433808 1 0 0 inhibits ubiquitination of itself, inhibits AKT phosphorylation and PI3K/AKT pathway +CAMK2A CAMK2A iso2 EC 2.7.11.17; KINASE; Kinase, protein; Protein kinase, CAMK; Protein kinase, Ser/Thr (non-receptor) Q9UQM7-2 815 5q32 human S332-p 3143902 DGVKKRKsSSSVQLM intracellular localization 9677407 3 1 0 blocks nuclear localization +H3-3A H3F3A DNA-binding P84243 3020 1q42.12 human S28-p 18545302 ATKAARKsAPSTGGV Histone phosphorylation 16185088 4 12 0 detecting S10 phosphorylation with phospho-antibody was disrupted in dual modified peptides with K9ac and K9 monomethyl as was S28 with K27ac +DNER DNER Membrane protein, integral; Receptor, misc. Q8NFT8 92737 2q36.3 human Y677-p 473321 QGSSRPAyEEFYNCR DNER_C intracellular localization 18474614 1 1 4 +Ptpro PTPRO EC 3.1.3.48; Membrane protein, integral; Motility/polarity/chemotaxis; PHOSPHATASE; Receptor protein phosphatase, tyrosine E9Q612 19277 6|6 G1 mouse Y1220-p 14312604 FCISDVIyENVSKS_ molecular association, regulation; phosphorylation cytoskeletal reorganization; signaling pathway regulation GRB2(INDUCES); Fyn(INDUCES) 20398064; 30622194 2 2 2 ; Y399F mutation reduces PRPRO ability to dephosphorylate Src Y527 +HAUS8 HAUS8 Cell cycle regulation Q9BT25 93323 19p13.11 human S19-p 20583302 PATGPTNsSSAKKKD molecular association, regulation; intracellular localization cell cycle regulation; cytoskeletal reorganization 21705324 2 1 0 disrupts microtubule binding +NFKBIA IkB-alpha DNA-binding; Inhibitor P25963 4792 14q13.2 human T291-p 451526 EDEESYDtESEFTEF protein degradation; intracellular localization carcinogenesis, induced 37377974; 8657113 5 0 0 regulates p65 nuclear translocation; S283/T291/T299A triple mutant showed increased IkB-alpha stability. +RAB7A Rab7 G protein; G protein, monomeric; G protein, monomeric, Rab P51149 7879 3q21.3 human S72-p 468547 AGQERFQsLGVAFYR Ras molecular association, regulation; intracellular localization; phosphorylation; enzymatic activity, induced autophagy, induced; endocytosis, inhibited CCZ1(DISRUPTS); GDI1(DISRUPTS) 26869029; 36344490; 36408770 7 50 21 induces mitophagy; induces ERK1/2 and P38 phosphorylation and activation, inhibits EGFR degradation +NLRP3 NLRP3 Inhibitor Q96P20 114548 1q44 human S198-p 230295300 GKTKTCEsPVSPIKM FISNA activity, induced; molecular association, regulation; ubiquitination; protein conformation ASCC1(INDUCES) 28943315 5 2 0 deubiquitination; assembly of NLRP3 oligomers; inflammasome activation +IGFBP1 IGFBP1 Secreted; Secreted, signal peptide P08833 3484 7p12.3 human S123-p 4668105 AEAGSPEsPESTEIT molecular association, regulation; activity, inhibited signaling pathway regulation IGF1(INDUCES); CK2B(INDUCES) 20143870; 32502935 7 8 0 regulates mTOR and AAR signaling +Gjb3 GJB3 Channel, misc.; Membrane protein, integral; Membrane protein, multi-pass P28231 14620 4 D2.2|4 61.48 cM mouse S266-p 2907500 KLQASAPsLTPI___ activity, induced; protein stabilization 15023533 1 1 0 +Lmna lamin A/C Cytoskeletal P48678 16905 3 F1|3 38.84 cM mouse S404-p 478681 RSRGRASsHSSQSQG protein degradation; intracellular localization cell differentiation, induced; cytoskeletal reorganization 33462407 8 49 106 +SRC Src EC 2.7.10.2; KINASE; Kinase, protein; Oncoprotein; Protein kinase, TK; Protein kinase, tyrosine (non-receptor) P12931 6714 20q11.23 human S43-p 31885161 QTPSKPAsADGHRGP phosphorylation; enzymatic activity, induced 33388549 2 1 0 induces phosphorylation at Y419 +IRF4 IRF4 DNA-binding; Oncoprotein; Transcription factor Q15306 3662 6p25.3 human K103-ac 6215734 RLRCALNkSNDFEEL IRF intracellular localization apoptosis, induced; transcription, inhibited 34793338 1 1 1 impaired IRF4 nuclear localization +Foxo1 FOXO1A DNA-binding; Nuclear receptor co-regulator; Oncoprotein; Transcription factor G3V7R4 84482 2q26 rat S250-p 448075 SPRRRAAsMDNNSKF protein degradation; ubiquitination; intracellular localization apoptosis, induced; signaling pathway regulation 34057658 98 8 48 regulates PHLPP1/FoxO1?Mdm2 pathway +NRL NRL DNA-binding; Transcription factor P54845 4901 14q11.2-q12 human S50-p 478419 PYSSVPPsPTFSEPG activity, inhibited transcription, altered 17335001 2 0 1 +SSH1 SSH1 EC 3.1.3.16; EC 3.1.3.48; PHOSPHATASE; Protein phosphatase, dual-specificity Q8WYL5 54434 12q24.11 human T826-p 35524905 AGLVRKHtKELERLK phosphorylation 25100728 1 0 0 induce coflin dephosphorylation +CHEK2 Chk2 EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, CAMK; Protein kinase, Ser/Thr (non-receptor); Tumor suppressor O96017 11200 22q12.1 human T205-p 12473001 VFVFFDLtVDDQSVY enzymatic activity, inhibited cell cycle regulation 20126263 1 1 0 mutation of this site impairs checkpoint recovery +ARL4D ARL4D G protein; G protein, monomeric; G protein, monomeric, ARF; Nucleolus P49703 379 17q21.31 human S144-p 23083814 QDQPGALsAAEVEKR Arf protein stabilization; molecular association, regulation; ubiquitination; intracellular localization cell motility, induced HYPK(INDUCES) 35857868 1 1 1 inhibits ubiquitination +PDCD1 PD-1 Apoptosis; Membrane protein, integral Q15116 5133 2q37.3 human S261-p 1881448300 PSGMGTSsPARRGSA protein degradation; ubiquitination; intracellular localization carcinogenesis, inhibited; cell growth, inhibited; apoptosis, induced FBXW7(INDUCES); KPNA2(INDUCES) 36104103 1 0 0 +AR AR DNA-binding; Nuclear receptor; Transcription factor P10275 367 Xq12 human S651-p 448414 GEASSTTsPTEETTQ intracellular localization transcription, altered 16282370; 30644418; 7565807 11 4 0 +PIN1 PIN1 EC 5.2.1.8; Isomerase; Nuclear receptor co-regulator Q13526 5300 19p13.2 human S16-p 447772 PGWEKRMsRSSGRVY WW protein degradation; molecular association, regulation; ubiquitination; intracellular localization; phosphorylation cell cycle regulation BORA(DISRUPTS); PPP1R2(INDUCES) 11723108; 18062707; 22158035; 23090969; 23970419 12 2 0 +TET2 TET2 EC 1.14.11.n2; Oxidoreductase; Tumor suppressor Q6N021 54790 4q24 human S99-p 3202572 GGIKRTVsEPSLSGL molecular association, regulation; protein stabilization carcinogenesis, inhibited; signaling pathway regulation 14-3-3 beta(INDUCES); 14-3-3 theta(INDUCES); 14-3-3 zeta(INDUCES); 14-3-3 epsilon(INDUCES); 14-3-3 eta(INDUCES) 30022161; 31901078 3 17 5 Glucose-AMPK-TET2-5hmc pathway +CSF1R CSFR EC 2.7.10.1; KINASE; Kinase, protein; Membrane protein, integral; Oncoprotein; Protein kinase, TK; Protein kinase, tyrosine (receptor) P07333 1436 5q32 human Y546-p 2866400 KYKQKPKyQVRWKII molecular association, regulation 8798707 4 0 0 binds to an unidentfied 55 KD phosphorylated protein in vitro. +H2AC11 H2A.1 DNA-binding P0C0S8 8329 6p22.1 human R29-m2 22267604 GLQFPVGrVHRLLRK Histone transcription, inhibited 21774791 1 1 0 +Card11 CARD11 Adaptor/scaffold Q8CIS0 108723 5|5 G2 mouse S577-p 457641 AEPPGNDsIVRRCKE enzymatic activity, induced signaling pathway regulation 31391255 3 1 0 antigen receptor signaling +EZR Ezrin Cytoskeletal; Motility/polarity/chemotaxis P15311 7430 6q25.3 human Y191-p 1783300 KDNAMLEyLKIAQDL FERM_M molecular association, regulation; phosphorylation Src(INDUCES) 15647376 2 2 2 +Arhgef6 ARHGEF6 GEF; GEF, Rac/Rho; Motility/polarity/chemotaxis Q8K4I3 73341 X|X A6 mouse S13-p 50175132 RLVTWLIsLGVLESP CH molecular association, regulation; enzymatic activity, induced cell cycle regulation; carcinogenesis, induced; cell motility, induced; cell growth, induced; signaling pathway regulation kindlin-2(INDUCES) 34321603 1 1 0 induces Rac 1 activity and MAPK signaling +Zc3h12a MCPIP1 EC 3.1.-.-; Hydrolase Q5D1E7 230738 4|4 D2.2 mouse S513-p 34505699 YPSREYWsEPYPLPP protein degradation; protein stabilization; molecular association, regulation; intracellular localization RNA stability, induced 14-3-3 beta(INDUCES); MCPIP1(DISRUPTS) RNA(DISRUPTS) 31072819; 34636324 2 4 0 +Pde6g PDE6G EC 3.1.4.35; Nucleotide Metabolism - purine; Phosphodiesterase P09174 18588 11 E2|11 84.14 cM mouse T22-p 449334 RVIGGPVtPRKGPPK PDE6_gamma enzymatic activity, induced; phosphorylation 12624098; 17138607 5 1 5 decreases phospho-ERK; regulates rod light response +Ctbp1 CTBP1 Cell cycle regulation; EC 1.1.1.-; Nuclear receptor co-regulator; Oxidoreductase; Transcription, coactivator/corepressor O88712 13016 5 B1|5 17.52 cM mouse S158-p 455351 REGTRVQsVEQIREV 2-Hacid_dh; 2-Hacid_dh_C protein degradation; intracellular localization transcription, induced 26416879 7 2 0 Unphosphorylated is stabilized in cytoplasm and nucleus. +NOX4 NOX4 Cell cycle regulation; EC 1.6.3.-; Membrane protein, integral; Membrane protein, multi-pass; Nucleolus; Oxidoreductase Q9NPH5 50507 11q14.3 human Y566-p 57848101 LSNQNNSyGTRFEYN molecular association, regulation; enzymatic activity, inhibited CYBA(DISRUPTS) 27525436 1 1 0 +Dnm2 DYN2 EC 3.6.5.5; Hydrolase; Microtubule-binding; Motility/polarity/chemotaxis; Vesicle P39052 25751 8q13 rat Y597-p 451200 NTEQRNVyKDLRQIE PH molecular association, regulation; intracellular localization carcinogenesis, induced; cell motility, induced; cell growth, induced; exocytosis, induced; cytoskeletal reorganization caveolin-1(INDUCES) 15007081; 20231454; 21841817 5 1 2 DYN2 Y597 is required for endocytosis and albumin transport. ; Golgi integrity and vesiculation during the secretory process; Wild-type showed increased motility and increase of large distal tumors, compared to Y231/597F mutant. +LIME1 LIME1 Adaptor/scaffold; Membrane protein, integral Q9H400 54923 20q13.33 human Y167-p 463652 ASPVVAEyARVQKRK LIME1 molecular association, regulation CSK(INDUCES) 14610046 1 1 11 +VDR VDR DNA-binding; Nuclear receptor; Transcription factor P11473 7421 12q13.11 human S182-p 454433 TPSFSGDsSSSCSDH molecular association, regulation transcription, inhibited RXRA(DISRUPTS) 15474498 1 0 0 +ALOX5 5-LO EC 1.13.11.34; Lipid Metabolism - arachidonic acid; Lipid Metabolism - linoleic acid; Nuclear envelope; Oxidoreductase P09917 240 10q11.21 human S272-p 450169 CSLERQLsLEQEVQQ Lipoxygenase intracellular localization; enzymatic activity, induced 11844797; 12670876; 16165096; 18978352; 26173130; 28257804 9 1 2 +MAPT Tau iso8 ACETYLTRANSFERASE; Acetyltransferase; Cytoskeletal P10636-8 4137 17q21.31 human K369-ac 461556 HVPGGGNkKIETHKL phosphorylation 28855586 4 2 27 inhibts Tau iso8 phosphorylation and microtubule binding, ameliorates amyloid-beta toxicity +Aqp4 AQP4 Channel, misc.; Membrane protein, integral; Membrane protein, multi-pass; Transporter; Transporter, aquaporin family P47863 25293 18p13 rat S180-p 467301 TIFASCDsKRTDVTG MIP molecular association, regulation; protein conformation AQP4(INDUCES) 23651078 4 0 0 phosphosite of monomer D is involved in an ionic interaction with monomer B and C +ATG7 ATG7 Autophagy; Ubiquitin conjugating system O95352 10533 3p25.3 human K413-ub 1881880200 CLGGGKPkALAAADR ubiquitination autophagy, induced 35316220 1 1 0 L. monocytogenes infection induced autophagosome accumulation +DAB2 DAB2 Adaptor/scaffold; Tumor suppressor P98082 1601 5p13.1 human S394-p 483636 NGFSVKSsPNPFVGS molecular association, regulation CLTA(INDUCES) 21097498 2 12 0 +MAPT Tau iso8 ACETYLTRANSFERASE; Acetyltransferase; Cytoskeletal P10636-8 4137 17q21.31 human K254-ub 486344 PVPMPDLkNVKSKIG Tubulin-binding protein stabilization 16443603 2 4 0 +CYP17A1 CYP17A1 EC 1.14.99.9; EC 4.1.2.30; Lipid Metabolism - C21-steroid hormone; Oxidoreductase P05093 1586 10q24.32 human S258-p 464643 KEKFRSDsITNMLDT p450 enzymatic activity, inhibited; enzymatic activity, induced 16616104; 20160131 2 0 0 in vitro; S258 mutants were impaired in both 17alpha-hydroxylase and C(17-20) lyase activities +MECP2 MECP2 Transcription, coactivator/corepressor P51608 4204 Xq28 human Y120-p 37042901 SGRSAGKyDVYLINP MBD molecular association, regulation; intracellular localization; protein conformation cell cycle regulation; cell motility, inhibited DNA(DISRUPTS) 25527496; 29428602 2 0 0 localized to the centrosome, colocalized with gamma-tubuliin and pericentrin +FOXP3 FOXP3 C2H2-type zinc finger protein; Cell cycle regulation; DNA-binding; Transcription factor Q9BZS1 50943 Xp11.23 human K252-ac 31914103 QLVLEKEkLSAMQAH FOXP-CC protein stabilization 23644046 1 0 0 +Celf1 CELF1 Cell development/differentiation; RNA processing; RNA-binding P28659 13046 2 E1|2 50.44 cM mouse S302-p 3347301 TSSGSSPsSSSSNSV protein stabilization translation, inhibited 28559429 6 1 0 +KDR VEGFR2 EC 2.7.10.1; KINASE; Kinase, protein; Membrane protein, integral; Protein kinase, TK; Protein kinase, tyrosine (receptor) P35968 3791 4q12 human Y1054-p 447899 FGLARDIyKDPDYVR PK_Tyr_Ser-Thr molecular association, regulation; receptor internalization, altered; enzymatic activity, induced PLCG1(INDUCES); CBL(INDUCES) 10102632; 17372230 14 3 105 +Fndc5 FNDC5 Membrane protein, integral Q8K4Z2 384061 4|4 D2.2 mouse K187-ac 1881215702 EPNNNKEkTKSASET ubiquitination 33754067 1 0 0 SIRT2-dependent deacetylation and deubiquitination increases stability +YAP1 YAP1 Oncoprotein; Transcription, coactivator/corepressor P46937 10413 11q22.1 human T83-p 27460703 KTANVPQtVPMRLRK molecular association, regulation; intracellular localization carcinogenesis, inhibited; transcription, inhibited KPNA1(DISRUPTS); KPNA7(DISRUPTS) 32271880 1 2 0 +NKX3-1 NKX3-1 DNA-binding; Transcription factor; Tumor suppressor Q99801 4824 8p21.2 human S196-p 4825100 GDLEKHSsLPALKEE protein degradation; ubiquitination 18757402 2 1 0 +NR3C1 GR DNA-binding; Mitochondrial; Nuclear receptor; Transcription factor P04150 2908 5q31.3 human T524-p 1872513504 NKTIVPAtLPQLTPT molecular association, regulation 14-3-3 zeta(INDUCES) 33744286 1 1 0 +Myocd myocardin Cell development/differentiation; Transcription factor Q8VIM5 214384 11|11 B3 mouse S812-p 10791200 EVLLNSHsPIGKVSD molecular association, regulation transcription, inhibited CBP(DISRUPTS) 19776005 1 0 0 +FOXP3 FOXP3 C2H2-type zinc finger protein; Cell cycle regulation; DNA-binding; Transcription factor Q9BZS1 50943 Xp11.23 human S274-p 34370255 TKASSVAsSDKGSCC protein degradation; ubiquitination 27432879 1 1 1 +SLC4A4 SLC4A4 Membrane protein, integral; Membrane protein, multi-pass; Transporter; Transporter, SLC family Q9Y6R1 8671 4q13.3 human S1026-p 469803 KKKKKKGsLDSDNDD activity, induced; molecular association, regulation CA2(INDUCES) 12411514; 12730338 3 10 2 S1026 phosphorylation alters stoichiometry shift, while T49 mediates increase in membrane conductance. +Kcnb1 Kv2.1 Channel, cation; Channel, ligand-gated; Channel, potassium; Membrane protein, integral; Membrane protein, multi-pass P15387 25736 3q42 rat S771-p 473561 QLLYSVDsSPPKSLH activity, inhibited 16917065 1 0 0 +TUBA1A TUBA1A Cytoskeletal; Motility/polarity/chemotaxis P81947 404053 cow K40-ac 460619 DGQMPSDkTIGGGDD Tubulin molecular association, regulation; acetylation; protein conformation cytoskeletal reorganization 19118000; 23110214 71 7 11 +NOTCH1 Notch 1 Membrane protein, integral; Motility/polarity/chemotaxis; Oncoprotein; Receptor, misc.; Transcription factor P46531 4851 9q34.3 human S2524-p 467290 PDQWSSSsPHSNVSD protein degradation; receptor inactivation, altered 16880534 1 0 0 Alanine mutation of 4 serines (S2522/S2523/S2524/S2525) causes increased protein stability. +FGFR3 FGFR3 EC 2.7.10.1; KINASE; Kinase, protein; Membrane protein, integral; Protein kinase, TK; Protein kinase, tyrosine (receptor) P22607 2261 4p16.3 human Y577-p 463335 RRPPGLDySFDTCKP PK_Tyr_Ser-Thr cell growth, altered 11294897 1 1 8 +DYRK2 DYRK2 iso2 EC 2.7.12.1; KINASE; Kinase, protein; Protein kinase, CMGC; Protein kinase, dual-specificity (non-receptor) Q92630-2 8445 12q15 human S498-p 1874397820 SKLPPPSsSASKLRT enzymatic activity, induced cell cycle regulation; apoptosis, induced 34363019 1 1 0 +TNNI3 TNNI3 Actin-binding; Motility/polarity/chemotaxis; Motor P19429 7137 19q13.42 human S44-p 450691 KKSKISAsRKLQLKT molecular association, regulation; activity, inhibited TNNC1(DISRUPTS) 15134451; 24116014 22 3 0 reduced maximal force generation +UVRAG UVRAG Autophagy Q9P2Y5 7405 11q13.5 human K517-ub 1871613604 ENERLQYkTPPPSYN autophagy, induced 30686098 1 0 0 +Skp2 SKP2 Cell cycle regulation; UBIQUITIN LIGASE; Ubiquitin conjugating system; Ubiquitin ligase Q9Z0Z3 27401 15|15 A1 mouse S256-p 1296362400 ATLLSSCsRLDELNL molecular association, regulation; ubiquitination; phosphorylation carcinogenesis, induced; cell motility, induced; transcription, induced; signaling pathway regulation CUL1(INDUCES) 30413706 3 1 0 induces ubiquitination and phosphorylation of AKT, GLUT1 transcription, induces AKT signaling +MDM2 MDM2 EC 6.3.2.-; EC 6.3.2.19; Inhibitor; Ligase; NEDDYLATION LIGASE; Neddylation Ligase; Nucleolus; Oncoprotein; UBIQUITIN LIGASE; Ubiquitin conjugating system; Ubiquitin ligase Q00987 4193 12q15 human S395-p 447898 SQESEDYsQPSTSSS protein degradation; protein stabilization; molecular association, regulation; ubiquitination; intracellular localization; enzymatic activity, inhibited; protein conformation cell cycle regulation; carcinogenesis, inhibited; cell growth, inhibited; signaling pathway regulation; translation, induced Rb(INDUCES); p53(DISRUPTS) RNA(INDUCES) 12383858; 17936559; 21986495; 24813712; 27215386; 31163228; 31652301; 32453417; 33400740; 33683975; 35674210 15 2 0 prevents E2F1 mRNA interaction; induces TP53 stabilization; induces binding to p53 mRNA; induces MDM2 p53 pathway; induce its RNA binding conformation, but also to govern MDM4 binding to p53 mRNA +IQGAP1 IQGAP1 GAP; GAP, Ras; Motility/polarity/chemotaxis P46940 8826 15q26.1 human S1441-p 455635 TPDKMKKsKSVKEDS molecular association, regulation cytoskeletal reorganization; cell adhesion, inhibited RAC1(DISRUPTS) 15695813; 28739799 4 3 2 +TP53 p53 Activator; DNA-binding; Motility/polarity/chemotaxis; Nuclear receptor co-regulator; Transcription factor; Tumor suppressor P04637 7157 17p13.1 human K373-ub 464659 SSHLKSKkGQSTSRH protein degradation; molecular association, regulation; intracellular localization transcription, inhibited ING1(DISRUPTS) 11046142; 17371868; 19927155; 21731648 9 0 0 K370/372/373/381/382/386/R mutant shows 613-fold activation of p53; binds unmodified or six multimonoubiquitinated forms of wild-type p53 +CNN1 calponin 1 Actin-binding; Contractile; Motility/polarity/chemotaxis; Myosin-binding P26932 396522 chicken T184-p 469595 QGMTAYGtRRHLYDP Calponin molecular association, regulation ACTA1(DISRUPTS) 10873572 1 0 1 f-actin (rabbit skeletal muscle) shown by co-sedimentation +Cdkn1a p21Cip1 Cell cycle regulation; Inhibitor Q64315 114851 rat S146-p 447836 GRKRRQTsLTDFYHS cell cycle regulation; carcinogenesis, induced 34569407 10 1 0 +P2rx2 P2X2 Channel, cation; Channel, ligand-gated; Membrane protein, integral; Membrane protein, multi-pass P49653 114115 12q16 rat T18-p 450951 SAFWDYEtPKVIVVR P2X_receptor receptor desensitization, altered 10744703 1 0 0 +H2AZ1 H2AZ DNA-binding P0C0S5 3015 4q23 human K101-m2 62489900 EELDSLIkATIAGGG Histone_H2A_C protein stabilization; molecular association, regulation cell cycle regulation; carcinogenesis, induced; chromatin organization, altered; cell growth, induced; transcription, induced LANP-L(DISRUPTS) 27569210 1 0 0 decreases histone displacement on chromatin +ENPP2 ENPP2 EC 3.1.4.39; Lipid Metabolism - ether lipid; Motility/polarity/chemotaxis; Phosphodiesterase; Secreted; Secreted, signal peptide Q13822 5168 8q24.12 human T210-p 451183 RPVYPTKtFPNLYTL Phosphodiest molecular association, regulation; protein conformation 27268273 2 0 0 ENPP2 follows the associative two-step in-line displacement mechanism +ITGB4 ITGB4 iso2 Cell adhesion; Membrane protein, integral; Motility/polarity/chemotaxis; Receptor, misc. P16144-2 3691 17q25.1 human Y1494-p 456323 LQGYSVEyQLLNGGE fn3 activity, induced; molecular association, regulation; intracellular localization cell motility, altered; autophagy, inhibited ANXA7(INDUCES); SHP-2(INDUCES) 20855525; 24007983; 26918348 6 0 1 +Zfp809 ZFP809 Transcription factor G3X9G7 235047 9|9 A3 mouse K391-ub 63108400 YGIMDFVkAWSRCII protein degradation 28115710 1 0 0 +AP2B1 AP2B1 Vesicle P63010 163 17q12 human Y277-p 462925 LPKDSDYyNMLLKKL Adaptin_N molecular association, regulation; intracellular localization DNA(DISRUPTS) 31492751 1 1 7 +EIF4B EIF4B RNA-binding; Translation; Translation initiation P23588 1975 12q13.13 human S504-p 452271 SSDTEQQsPTSGGGK neural plasticity; translation, induced 21635931 2 55 22 +ADRA1D ADRA1D GPCR, family 1; Membrane protein, integral; Membrane protein, multi-pass; Receptor, GPCR P25100 146 20p13 human T507-p 1346843002 LGPFRRPtTQLRAKV receptor internalization, induced; molecular association, regulation; intracellular localization; receptor internalization, altered signaling pathway regulation ARRB1(INDUCES) 29551601; 30419287 2 1 0 triggers the calcium signaling pathway; regulates ERK signaling pathway, induces calcium signaling de-sensitization +PML PML Nucleolus; Oncoprotein; SUMO LIGASE; SUMO conjugating system; SUMO ligase; Transcription factor; Tumor suppressor; Ubiquitin conjugating system P29590 5371 15q24.1 human K401-ub 2885407 KDAAVSKkASPEAAS DUF3583 protein degradation cell differentiation, induced 18408733 1 4 4 +SMAD2 SMAD2 DNA-binding; Transcription factor Q15796 4087 18q21.1 human S417-p 447569 RMCTIRMsFVKGWGA MH2 molecular association, regulation transcription, inhibited; signaling pathway regulation SMAD4(DISRUPTS); TGFBR1(DISRUPTS) 22393057 1 1 0 TGFB signaling +ABL2 Arg EC 2.7.10.2; KINASE; Kinase, protein; Oncoprotein; Protein kinase, TK; Protein kinase, tyrosine (non-receptor) P42684 27 1q25.2 human Y161-p 449482 QGWVPSNyITPVNSL enzymatic activity, induced 34144039 2 5 215 +SIK2 QIK EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, CAMK; Protein kinase, Ser/Thr (non-receptor) Q9H0K1 23235 11q23.1 human T175-p 456035 KSGELLAtWCGSPPY Pkinase enzymatic activity, induced 24841198; 27478041 6 1 0 +BRCA1 BRCA1 EC 6.3.2.-; Nuclear receptor co-regulator; Transcription, coactivator/corepressor; Tumor suppressor; UBIQUITIN LIGASE; Ubiquitin conjugating system; Ubiquitin ligase P38398 672 17q21.31 human S1423-p 448036 AVLEQHGsQPSNSYP molecular association, regulation; phosphorylation cell cycle regulation; DNA repair, altered ATM(INDUCES) 10550055; 11313470; 12183412; 15159397; 25939603; 26320175; 34301763 14 1 1 +FGFR2 FGFR2 EC 2.7.10.1; KINASE; Kinase, protein; Membrane protein, integral; Oncoprotein; Protein kinase, TK; Protein kinase, tyrosine (receptor) P21802 2263 10q26.13 human Y656-p 472824 RDINNIDyYKKTTNG PK_Tyr_Ser-Thr carcinogenesis, induced; cell growth, induced 35428876 2 8 66 +CHAT CHAT iso3 ACETYLTRANSFERASE; Acetyltransferase; EC 2.3.1.6; Lipid Metabolism - glycerophospholipid P28329-3 1103 10q11.23 human T255-p 454038 TVLVKDStNRDSLDM Carn_acyltransf enzymatic activity, induced 15381704 1 0 0 +Dnm1l DRP1 Apoptosis; EC 3.6.5.5; Endoplasmic reticulum; Hydrolase; Microtubule-binding; Mitochondrial; Motor O35303 114114 11q23 rat S656-p 483971 VPVARKLsAREQRDC molecular association, regulation; intracellular localization autophagy, induced; apoptosis, inhibited; autophagy, inhibited; cytoskeletal reorganization FIS1(INDUCES) 17721437; 18695047; 21637291; 29313986; 33624140; 35562960; 36805606 103 3 0 +Foxo1 FOXO1A DNA-binding; Nuclear receptor co-regulator; Oncoprotein; Transcription factor Q9R1E0 56458 3 C|3 23.19 cM mouse T24-p 448560 LPRQRSCtWPLPRPE intracellular localization transcription, inhibited 10377430; 10698940; 22848439 62 6 39 enhances hypoglycemic effect +PKM PKM Carbohydrate Metabolism - glycolysis and gluconeogenesis; Carbohydrate Metabolism - pyruvate; EC 2.7.1.40; KINASE; Kinase, other; Mitochondrial; Nucleotide Metabolism - purine P14618 5315 15q23 human K206-ub 12412148 NGGSLGSkKGVNLPG PK enzymatic activity, inhibited carcinogenesis, inhibited; cell growth, inhibited 26975375 1 3 10 +Nr5a2 NR5A2 DNA-binding; Nuclear receptor; Transcription factor P45448 26424 1 59.98 cM|1 E4 mouse K173-sm 6124700 KCIDVGMkLEAVRAD zf-C4 intracellular localization transcription, inhibited 19125815 1 0 0 +Bmal1 BMAL1 DNA-binding; Transcription factor Q9WTL8 11865 7 F1|7 59.17 cM mouse S522-p 1878257206 IRGSSPSsCGSSPLN activity, induced transcription, induced 35902736 1 1 0 +Banp BANP Tumor suppressor Q8VBU8 53325 8 E1|8 70.82 cM mouse S347-p 475059 SFSRRTPsSSSYSAS intracellular localization cell cycle regulation; cell growth, inhibited 17229733; 20006573 2 0 0 translocation from nucleus to cytoplasm; anti-tumorigenic activity, P44 peptide could efficiently activate p53 +OCLN occludin Cell adhesion; Membrane protein, integral; Membrane protein, multi-pass; Motility/polarity/chemotaxis Q16625 100506658 5q13.2 human Y398-p 5393504 KRTEQDHyETDYTTG molecular association, regulation; intracellular localization ZO1(INDUCES) 19017651 1 3 1 +KAT2B PCAF ACETYLTRANSFERASE; Acetyltransferase; EC 2.3.1.48; Nuclear receptor co-regulator Q92831 8850 3p24.3 human K89-m1 7482014 LRSAPRAkKLEKLGV PCAF_N intracellular localization 19351588 1 0 0 +Cycs CYCS Apoptosis; Mitochondrial; Oxidoreductase; PHOSPHATASE; Protein phosphatase, Ser/Thr (non-receptor) P62897 13063 6 B2.3|6 24.32 cM mouse T29-p 4710693 EKGGKHKtGPNLHGL Cytochrom_C protein stabilization; enzymatic activity, inhibited 27758862 1 12 0 +STX3 STX3 Cell adhesion; Membrane protein, integral; Vesicle Q13277 6809 11q12.1 human T14-p 31960301 QLKAKQLtQDDDTDA molecular association, regulation; protein conformation VAMP2(INDUCES); STXBP1(DISRUPTS); SNAP-25(INDUCES) 35661757 5 1 0 +FZR1 FZR1 UBIQUITIN LIGASE; Ubiquitin conjugating system Q9UM11 51343 19p13.3 human T121-p 3827860 DRRLQPStPEKKGLF protein stabilization; activity, inhibited apoptosis, induced 18818692; 30498084 3 1 16 inhibits cyclin B1 degradation; AURKA stabilization +PGK1 PGK1 Carbohydrate Metabolism - glycolysis and gluconeogenesis; EC 2.7.2.3; KINASE; Kinase, other P00558 5230 Xq21.1 human Y76-p 463986 GVPMPDKySLEPVAV PGK molecular association, regulation cell growth, altered RNA(DISRUPTS) 19784757 1 4 102 binds to uPAR mRNA and regulates the uPAR expression induced by uPA treatment +Mst1r Ron EC 2.7.10.1; KINASE; Kinase, protein; Membrane protein, integral; Protein kinase, TK; Protein kinase, tyrosine (receptor) Q62190 19882 9 59.07 cM|9 F1 mouse Y1265-p 456483 LTRGAPPyPHIDPFD PK_Tyr_Ser-Thr enzymatic activity, induced Src(NOT_REPORTED) 16103119 1 0 0 this site is responsible for constitutive activation of the MAP kinase pathway +Ccdc88a girdin Actin-binding Q5SNZ0 108686 11|11 A3.3 mouse S233-p 4725929 HASSSAQsPCGSPGM molecular association, regulation SLC3A2(INDUCES) 29538402 1 16 7 negatively regulates amino acid signaling +MLLT1 MLLT1 Oncoprotein; Transcription regulation Q03111 4298 19p13.3 human S398-p 40666502 FEPSQNHsQGPLRSM molecular association, regulation transcription, inhibited BMI1(INDUCES) 25921070 1 0 0 +UBE2I UBC9 EC 6.3.2.-; EC 6.3.2.19; Ligase; Nuclear receptor co-regulator; SUMO LIGASE; SUMO conjugating system; SUMO ligase; UBIQUITIN LIGASE; Ubiquitin conjugating system; Ubiquitin ligase P63279 7329 16p13.3 human T35-p 18914511 PTKNPDGtMNLMNWE UQ_con sumoylation cell growth, induced; transcription, induced 25867063 1 1 0 induces global sumoylation +LSR LISCH Membrane protein, integral; Receptor, misc. Q86X29 51599 19q13.12 human S493-p 468133 ARRPRARsVDALDDL molecular association, regulation 14-3-3 beta(INDUCES) 19648646 1 38 49 yeast 14-3-3 used for binding assay +CAMK4 CAMK4 EC 2.7.11.17; KINASE; Kinase, protein; Protein kinase, CAMK; Protein kinase, Ser/Thr (non-receptor) Q16566 814 5q22.1 human S12-p 2135600 TVPSCSAsSCSSVTA transcription, altered 8702940 1 0 1 +ATR ATR EC 2.7.11.1; KINASE; Kinase, protein; Membrane protein, integral; Protein kinase, Ser/Thr (non-receptor); Protein kinase, atypical Q13535 545 3q23 human T1566-p 22561301 DDQHTINtQDIASDL cell cycle regulation; cell growth, induced 21908846 1 1 0 +Cycs CYCS Apoptosis; Mitochondrial; Oxidoreductase; PHOSPHATASE; Protein phosphatase, Ser/Thr (non-receptor) P62898 25309 4q24 rat Y49-p 473243 GQAAGFSyTDANKNK Cytochrom_C molecular association, regulation; activity, inhibited apoptosis, altered 20586425 4 4 4 Y48E mutation decreases CYCS redox potential; decreases affinity to cardiolipin +STK11 LKB1 Autophagy; EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, CAMK; Protein kinase, Ser/Thr (non-receptor); Tumor suppressor Q15831 6794 19p13.3 human T363-p 448151 IEDDIIYtQDFTVPG enzymatic activity, induced 12805220 6 0 0 STRAD increases LKB1 activation +MPLKIP TTDN1 Cell cycle regulation Q8TAP9 136647 7p14.1 human T120-p 478367 QGSPRTStPFGSGRV MPLKIP molecular association, regulation PLK1(INDUCES) 17310276 1 8 16 +PEAK1 PEAK1 EC 2.7.10.2; KINASE; Kinase, protein; Protein kinase, Other; Protein kinase, Ser/Thr (non-receptor) Q9H792 79834 15q24.3 human Y635-p 449709 IVINPNAyDNLAIYK molecular association, regulation cell motility, induced; cell growth, induced; cytoskeletal reorganization GRB2(INDUCES); SHC1(INDUCES); tensin 3(INDUCES) 23378338; 35687021 2 43 1179 +Kcnb1 Kv2.1 Channel, cation; Channel, ligand-gated; Channel, potassium; Membrane protein, integral; Membrane protein, multi-pass P15387 25736 3q42 rat Y814-p 22874700 FLRPNCVySSEGLTG intracellular localization 22106938 2 1 1 regulates intracellular trafficking of Kv2.1 +ANKRD28 ANKRD28 Protein phosphatase, regulatory subunit O15084 23243 3p25.1 human S1011-p 459225 TNTSKTVsFEALPIM intracellular localization transcription, inhibited PPP1CA(DISRUPTS) 16564677; 17023142 2 25 0 +Ano1 ANO1 Membrane protein, integral; Membrane protein, multi-pass; Transporter; Transporter, ion channel Q8BHY3 101772 7|7 F5 mouse S673-p 288031701 YLKLRRQsPSDREEY Anoctamin activity, induced; protein conformation; activity, inhibited cell cycle regulation; cell growth, induced 29081444; 33199590 2 0 0 regulating ANO1 Cl- currents +KEAP1 KEAP1 Endoplasmic reticulum; Motility/polarity/chemotaxis; Transcription regulation; UBIQUITIN LIGASE; Ubiquitin conjugating system Q14145 9817 19p13.2 human K323-ub 1883516303 VMPCRAPkVGRLIYT protein degradation 36163178 1 0 0 +PLCG1 PLCG1 Carbohydrate Metabolism - inositol phosphate; EC 3.1.4.11; Motility/polarity/chemotaxis; Phospholipase P08487 281987 cow Y783-p 447667 EGRNPGFyVEANPMP enzymatic activity, induced transcription, altered 15879121 92 42 558 Mutation of Y775 or Y783 reduced PLCG1-mediated calcium mobilization and transcriptional activation +E2F4 E2F4 DNA-binding Q16254 1874 16q22.1 human S384-p 4763386 FAPLLRLsPPPGDHD intracellular localization cell cycle regulation; transcription, induced 23919615 2 5 0 +Camk2b CAMK2B EC 2.7.11.17; KINASE; Kinase, protein; Protein kinase, CAMK; Protein kinase, Ser/Thr (non-receptor) P08413 24245 14q21 rat S343-p 7446037 GLVEQAKsLLNKKAD molecular association, regulation 26291163 1 10 1 inhibits interaction with F-actin, regulates synaptic plasticity +DNMT1 DNMT1 Amino Acid Metabolism - cysteine and methionine; Cell development/differentiation; EC 2.1.1.37; METHYLTRANSFERASE; Methyltransferase; Methyltransferase, DNA; Transcription regulation P26358 1786 19p13.2 human S143-p 3189394 RTPRRSKsDGEAKPE molecular association, regulation; protein stabilization; enzymatic activity, inhibited; methylation carcinogenesis, induced 14-3-3 beta(INDUCES); 14-3-3 gamma(INDUCES); 14-3-3 eta(INDUCES) 21151116; 26553800 3 28 6 inhibits K142 methylation; 14-3-3 overexpression results in genome hypomethylation with and cell invasion +FBXW7 FBXW7 Motility/polarity/chemotaxis; Nucleolus; UBIQUITIN LIGASE; Ubiquitin conjugating system; Ubiquitin ligase Q969H0 55294 4q31.3 human K404-ub 1881459300 GSDDNTLkVWSAVTG protein degradation; molecular association, regulation TRIP12(INDUCES) 33824312 1 1 0 +TFEB TFEB DNA-binding; Transcription factor P19484 7942 6p21.1 human S3-p 54467500 _____MAsRIGLRMQ molecular association, regulation; phosphorylation autophagy, induced mTOR(INDUCES) 29507340 1 0 0 +BRAF BRAF EC 2.7.11.1; KINASE; Kinase, protein; Oncoprotein; Protein kinase, Ser/Thr (non-receptor); Protein kinase, TKL P15056 673 7q34 human K601-ac 1876128200 DFGLATVkSRWSGSH PK_Tyr_Ser-Thr molecular association, regulation; enzymatic activity, induced carcinogenesis, induced BRAF(INDUCES); KSR(INDUCES); RAF1(INDUCES); RKIP(DISRUPTS) 35045286 1 1 0 facilitates melanoma tumorigenesis,dimerization +SREBF1 SREBP-1 DNA-binding; Membrane protein, integral; Membrane protein, multi-pass; Transcription factor P36956 6720 17p11.2 human K418-sm 2793924 DVLMEGVkTEVEDTL transcription, inhibited 12615929 1 0 0 +Usp20 USP20 DEUBIQUITINASE; EC 3.4.19.12; Protease; Ubiquitin conjugating system; Ubiquitin-specific protease Q8C6M1 74270 2|2 B mouse S334-p 7323248 RMKDRKFsWGQQRTN molecular association, regulation; ubiquitination; intracellular localization; phosphorylation apoptosis, altered; cell motility, induced; cell growth, induced; signaling pathway regulation TRAF6(DISRUPTS); ADRB1(INDUCES) 30538132; 37311534 3 13 18 regulates NFKB signaling; deubiquitinates ?1AR and inhibits ?1AR trafficking to lysosomes +MAF MAF Cell development/differentiation; DNA-binding; Oncoprotein; Transcription factor; Tumor suppressor O75444 4094 16q23.2 human K85-ub 37043501 PGSGSEQkAHLEDYY protein degradation; protein stabilization cell growth, inhibited; transcription, induced 25448412; 26825710 2 0 0 +FOXO1 FOXO1A DNA-binding; Nuclear receptor co-regulator; Oncoprotein; Transcription factor Q12778 2308 13q14.11 human S322-p 449112 PRTSSNAsTISGRLS intracellular localization 11980723; 14664696 6 1 0 +HCN2 HCN2 Channel, cation; Membrane protein, integral; Membrane protein, multi-pass Q9UL51 610 19p13.3 human T576-p 15785721 DYIIREGtIGKKMYF cNMP_binding activity, inhibited apoptosis, inhibited 21037554 1 0 0 +DAG1 DAG1 Cytoskeletal; Membrane protein, integral; Motility/polarity/chemotaxis Q14118 1605 3p21.31 human Y892-p 449630 PYRSPPPyVPP____ DAG1 molecular association, regulation; intracellular localization utrophin(DISRUPTS) 10769203; 20512930 8 2 19 +PROM1 CD133 Cell surface; Membrane protein, integral; Membrane protein, multi-pass O43490 8842 4p15.32 human Y828-p 462569 RMDSEDVyDDVETIP molecular association, regulation ARL13B(INDUCES) 32201384 4 2 20 regulates ciliary length +MOB1A MOB1A Protein kinase, regulatory subunit Q9H8S9 55233 2p13.1 human T74-p 2506801 QINMLYGtITEFCTE Mob1_phocein molecular association, regulation NDR1(INDUCES); MST2(INDUCES) 18362890 1 0 0 a tripartite complex +Kcnb1 Kv2.1 Channel, cation; Channel, ligand-gated; Channel, potassium; Membrane protein, integral; Membrane protein, multi-pass Q03717 16500 2 H3|2 87.22 cM mouse S607-p 473555 EATRFSHsPLASLSG Kv2channel activity, induced 24962901 7 6 0 +PFKFB2 PFKFB2 Carbohydrate Metabolism - fructose and mannose; EC 2.7.1.105; EC 3.1.3.46; Kinase, other; Motility/polarity/chemotaxis; Phosphatase (non-protein) O60825 5208 1q32.1 human S483-p 452046 IRRPRNYsVGSRPLK molecular association, regulation 14-3-3 beta(INDUCES) 12853467 8 36 101 +PHB2 BAP37 Mitochondrial; Nuclear receptor co-regulator; Transcription, coactivator/corepressor Q99623 11331 12p13.31 human K200-ub 15385266 YTAAVEAkQVAQQEA Band_7 molecular association, regulation; ubiquitination autophagy, induced LC3B(INDUCES) 36379251 1 4 2 BAP37 promotes ef?cient mitophagy +FOXK2 FOXK2 DNA-binding; Transcription factor Q01167 3607 17q25.3 human S428-p 3193961 FAQSAPGsPLSSQPV protein stabilization apoptosis, altered; transcription, altered 20810654 1 43 5 +Kcnd2 Kv4.2 Channel, potassium; Membrane protein, integral; Membrane protein, multi-pass Q9Z0V2 16508 6 A2-A3.1|6 8.49 cM mouse S616-p 457613 EGDDRPEsPEYSGGN activity, induced; activity, inhibited neural plasticity 16600858; 18045912; 29790931; 32209671 8 0 0 +En2 En-2 DNA-binding; Transcription factor P09066 13799 5 B1|5 13.94 cM mouse S267-p 452011 LTEQRRQsLAQELSL Homeodomain transcription, altered 15196920 1 1 0 +NR1I2 PXR DNA-binding; Nuclear receptor O75469 8856 3q13.33 human T422-p 27839402 QDIHPFAtPLMQELF molecular association, regulation transcription, inhibited DNA(DISRUPTS) 22976785 1 0 0 +CDC25C CDC25C EC 3.1.3.48; Motility/polarity/chemotaxis; PHOSPHATASE; Protein phosphatase, dual-specificity P30307 995 5q31.2 human S216-p 448418 SGLYRSPsMPENLNR M-inducer_phosp molecular association, regulation; enzymatic activity, inhibited; intracellular localization cell cycle regulation 14-3-3 beta(INDUCES); 14-3-3 epsilon(INDUCES) 10681541; 11333986; 12766774; 15629715; 15735676; 15975956; 17409144; 20637859; 25809478; 34168048; 7982962; 9278512; 9543386 63 14 49 +Rb1 Rb Nuclear receptor co-regulator; Oncoprotein; Transcription, coactivator/corepressor; Tumor suppressor P13405 19645 14 38.73 cM|14 D3 mouse K713-sm 3817003 KVKNIDLkFKIIVTA RB_B protein stabilization; molecular association, regulation cell growth, induced lamin A/C(INDUCES) 27270425 2 0 0 +Brsk2 BRSK2 EC 2.7.11.1; EC 2.7.11.26; KINASE; Kinase, protein; Protein kinase, CAMK; Protein kinase, Ser/Thr (non-receptor) Q69Z98 75770 7|7 F5 mouse S514-p 3572419 SNLTPESsPELAKKS protein stabilization; enzymatic activity, inhibited; phosphorylation 23790753 1 9 6 inhibits axon branching (activated in BRSK2 18A mutant) +ERBB2 HER2 EC 2.7.10.1; KINASE; Kinase, protein; Membrane protein, integral; Oncoprotein; Protein kinase, TK; Protein kinase, tyrosine (receptor) P04626 2064 17q12 human Y1023-p 448682 DLVDAEEyLVPQQGF molecular association, regulation; activity, inhibited cell adhesion, altered; cell growth, altered SHP-2(INDUCES) 16729043; 18332126 7 4 36 +PITPNM1 PITPNM1 Cell surface O00562 9600 11q13.2 human S382-p 451453 DFIDAFAsPVEAEGT molecular association, regulation PLK1(INDUCES) 15125835 1 1 0 +TPI1 TPI1 iso3 Carbohydrate Metabolism - fructose and mannose; Carbohydrate Metabolism - glycolysis and gluconeogenesis; Carbohydrate Metabolism - inositol phosphate; EC 5.3.1.1; Isomerase P60174-3 7167 12p13.31 human S58-p 465652 KMNGRKQsLGELIGT TIM enzymatic activity, induced carcinogenesis, induced; cell motility, induced; cell growth, induced 34936872 3 67 124 +MTA1 MTA1 Motility/polarity/chemotaxis; Nuclear receptor co-regulator; Transcription, coactivator/corepressor Q13330 9112 14q32.33 human K532-m1 27583500 VLKQAVRkPLEAVLR MTA_R1 molecular association, regulation chromatin organization, altered; transcription, inhibited MBD3(INDUCES); CtIP(INDUCES); H3(INDUCES); FALZ(DISRUPTS); HDAC2(INDUCES); CHD-4(INDUCES) 23352453 1 0 0 induces H3Me2K9 loss from chromatin, induces interaction with H3MeK9, H3MeK4, H3AcK9 +RBBP8 CtIP EC 3.1.-.-; Transcription, coactivator/corepressor Q99708 5932 18q11.2 human T126-p 1275585105 ELMNERNtLQEENKK CtIP_N activity, induced DNA repair, induced 30297868 1 1 0 +SLC6A3 DAT Membrane protein, integral; Membrane protein, multi-pass; Transporter; Transporter, SLC family Q01959 6531 5p15.33 human S4-p 454428 ____MSKsKCSVGLM activity, induced 16908408 3 0 0 stimulates DAT-mediated efflux of dopamine +Neurod1 NEUROD1 DNA-binding; Transcription factor Q60867 18012 2 C3|2 47.58 cM mouse S259-p 465678 ALEPFFEsPLTDCTS Neuro_bHLH transcription, induced 12810726 1 0 0 +BNIP3 BNIP3 Membrane protein, integral; Mitochondrial Q12983 664 10q26.3 human S17-p 27421704 QEESLQGsWVELHFS BNIP3 protein stabilization; molecular association, regulation; intracellular localization autophagy, induced; cell growth, inhibited LC3B(INDUCES); GABARAPL2(INDUCES) 23209295; 34654847 2 0 0 modulates mitophagy; S82 is required for binding and S89 positively regulates the affinity for LC3B and GABARAPL2. Mitochondrial degradation. +Srpk2 SRPK2 EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, CMGC; Protein kinase, Ser/Thr (non-receptor) O54781 20817 5 A3|5 10.36 cM mouse T485-p 483237 PSHDRSRtVSASSTG intracellular localization; phosphorylation; enzymatic activity, induced transcription, altered 30373880 3 6 0 increases its nuclear translocation as well as kinase activity, phosphorylates Tau protein S214, regulates mRNA splicing +Trpc6 TRPC6 iso2 Channel, cation; Membrane protein, integral; Membrane protein, multi-pass Q99N77 89823 8q11 rat S714-p 455910 VPFNLVPsPKSLLYL molecular association, regulation Calmodulin(INDUCES); FKBP12(INDUCES); PPP3CA(INDUCES) 15994335 1 0 0 +Nrip1 RIP140 Nuclear receptor co-regulator; Transcription, coactivator/corepressor Q8CBD1 268903 16|16 C3.1 mouse K311-ac 459037 RLQENGQkDVGSSQL NRIP1_repr_1 intracellular localization transcription, inhibited 15879431 1 2 0 +CTNNB1 CTNNB1 Actin-binding; Cell adhesion; Motility/polarity/chemotaxis; Nuclear receptor co-regulator; Oncoprotein; Transcription factor P35222 1499 3p22.1 human T556-p 486193 RRTSMGGtQQQFVEG intracellular localization transcription, inhibited; signaling pathway regulation 31801859 1 26 1 inhibits cGAS/STING mediated DNA-sensing signaling pathway +SYK Syk EC 2.7.10.2; KINASE; Kinase, protein; Protein kinase, TK; Protein kinase, tyrosine (non-receptor) P43405 6850 9q22.2 human Y526-p 447662 LRADENYyKAQTHGK PK_Tyr_Ser-Thr enzymatic activity, induced carcinogenesis, induced; carcinogenesis, inhibited; cell growth, induced ITGAM(INDUCES) 11380624; 18818202; 30923129; 34132782; 37330581; 8657103 50 9 72 +Ikbkb IKKB EC 2.7.11.10; KINASE; Kinase, protein; Protein kinase, Other; Protein kinase, Ser/Thr (non-receptor) O88351 16150 8|8 A2 mouse S177-p 447492 AKELDQGsLCTSFVG Pkinase activity, induced; intracellular localization; phosphorylation; enzymatic activity, induced cell differentiation, induced; transcription, induced 20534585; 23332762; 36896602; 36914767 43 1 0 induces NFKB phosphorylation; induces IkBa degradation; constituvely active IKKE (EE mutant) phosphorylates S26 BAD; osteoclast differentiation +EGFR EGFR EC 2.7.10.1; KINASE; Kinase, protein; Membrane protein, integral; Oncoprotein; Protein kinase, TK; Protein kinase, tyrosine (receptor) P00533 1956 7p11.2 human K737-ub 1065304 LWIPEGEkVKIPVAI PK_Tyr_Ser-Thr receptor internalization, induced; receptor recycling, inhibited; protein degradation 16543144; 17940017 2 7 0 +PTPN18 BDP1 EC 3.1.3.48; Motility/polarity/chemotaxis; PHOSPHATASE; Protein phosphatase, tyrosine (non-receptor) Q99952 26469 2q21.1 human Y303-p 450260 LQNASPHyQNIKENC molecular association, regulation TEC(INDUCES) 14679216 1 0 0 +Sp4 SP4 C2H2-type zinc finger protein; DNA-binding; Transcription factor Q63158 25162 rat S769-p 17548374 VAAISQDsNPATPNV cell differentiation, inhibited 24475768 3 5 0 impairs CG neuron maturation +ACADVL ACADVL EC 1.3.8.9; Lipid Metabolism - fatty acid; Mitochondrial; Oxidoreductase P49748 37 17p13.1 human K299-ac 3811946 THGPPEKkMGIKASN Acyl-CoA_dh_M molecular association, regulation; enzymatic activity, induced CRLS1(INDUCES) 25811481 1 0 1 both SIRT3 and SIRT5 KO show reduced afinity for CRLS1 +STAP2 STAP2 Adaptor/scaffold Q9UGK3 55620 19p13.3 human Y22-p 11500606 GVLPSHYyESFLEKK PH transcription, altered 12540842 1 0 0 +GMFB GMF-beta Actin-binding; Inhibitor; Motility/polarity/chemotaxis P60983 2764 14q22.2 human S83-p 451485 QHDDGRVsYPLCFIF Cofilin_ADF signaling pathway regulation 32123210 2 0 0 p38MAPK pathway +MYH7 MYH7 Motility/polarity/chemotaxis; Motor P12883 4625 14q11.2 human K951-ac 15292422 EDECSELkRDIDDLE Myosin_tail_1 protein conformation 35502901 0 1 58 +CAV1 caveolin-1 Adaptor/scaffold; Motility/polarity/chemotaxis; Nuclear receptor co-regulator Q03135 857 7q31.2 human K30-ub 486850 NIYKPNNkAMADELS molecular association, regulation; intracellular localization UBXN6(INDUCES); VCP(INDUCES) 23335559 1 6 6 CAV1 ubiquitylation and binding to the VCP-UBXD1 complex and sorting into lysosomes +GAPDH GAPDH Carbohydrate Metabolism - glycolysis and gluconeogenesis; EC 1.2.1.12; Oxidoreductase P04406 2597 12p13.31 human T237-p 4658322 GMAFRVPtANVSVVD Gp_dh_C intracellular localization apoptosis, inhibited 21979951 2 4 32 increases cell survival +CDK16 CDK16 Cell cycle regulation; EC 2.7.11.22; KINASE; Kinase, protein; Motility/polarity/chemotaxis; Protein kinase, CMGC; Protein kinase, Ser/Thr (non-receptor) Q00536 5127 Xp11.3 human S153-p 453451 SRRLRRVsLSEIGFG molecular association, regulation; intracellular localization; enzymatic activity, inhibited cytoskeletal reorganization CBCP1(DISRUPTS) 12154078; 22184064 3 58 166 +Mkln1 MKLN1 Cell adhesion; Motility/polarity/chemotaxis O89050 27418 6|6 A3.3 mouse S324-p 474504 TEKENGPsARSCHKM Kelch_3 molecular association, regulation MKLN1(INDUCES) 17049906 1 0 0 mutation inhibited MKLN1 self-association +AFDN Afadin Cell adhesion; Motility/polarity/chemotaxis; Oncoprotein P55196 4301 6q27 human T909-p 6208300 VVTVAENtADELARS molecular association, regulation HRas(INDUCES) 12808105 1 0 0 phosphorylation by Bcr induces formation of a complex with Ras +Slc12a1 NKCC2 Membrane protein, integral; Membrane protein, multi-pass; Transporter; Transporter, SLC family P55016 25065 3q36 rat T96-p 458227 TNTYYLQtFGHNTMD AA_permease_N activity, induced; molecular association, regulation; intracellular localization ANXA2(DISRUPTS) 16275913; 18550832; 24526686 15 2 0 Low chloride hypotonic stress enhances raft association of NKCC2 and AnxA2; observed in triple mutant T96/111/101A +TRPC1 TRPC1 Channel, calcium; Membrane protein, integral; Membrane protein, multi-pass P48995 7220 3q23 human S206-p 35542201 SAKNKKDsLRHSRFR TRP_2 signaling pathway regulation 25139746 1 0 0 inhibits 11,12-EET-induced smooth muscle hyperpolarization and relaxation +CAMKK2 CAMKK2 Autophagy; EC 2.7.11.17; KINASE; Kinase, protein; Protein kinase, Other; Protein kinase, Ser/Thr (non-receptor) Q96RR4 10645 12q24.31 human S100-p 4755871 HLSGRKLsLQERSQG molecular association, regulation; enzymatic activity, inhibited; phosphorylation 14-3-3 beta(INDUCES) 32913128 1 27 0 inhibits dephosphorylation at S495 +PAX6 PAX6 iso2 DNA-binding; Motility/polarity/chemotaxis; Transcription factor P26367-2 5080 11p13 human K53-sm 1877427001 LQTHADAkVQVLDNQ PAX protein degradation 32826860 1 0 0 SENP1-mediated de-SUMOylation improves the stability of PAX6 and has protective effects of PAX6 on corneal endothelial injuries +KCNB1 Kv2.1 Channel, cation; Channel, ligand-gated; Channel, potassium; Membrane protein, integral; Membrane protein, multi-pass Q14721 3745 20q13.13 human Y128-p 449085 YWGIDEIyLESCCQA BTB_2 activity, induced; phosphorylation apoptosis, altered; apoptosis, induced 19622611; 26115091 7 0 0 induces phosphorylation of Kv2.1 at S800 +Cd79b Ig-beta Membrane protein, integral; Receptor, misc. P15530 15985 11 E1|11 68.89 cM mouse Y206-p 459287 NIDQTATyEDIVTLR ITAM phosphorylation 9531288 1 1 11 +Stub1 CHIP Adaptor/scaffold; EC 6.3.2.-; EC 6.3.2.19; Ligase; UBIQUITIN LIGASE; Ubiquitin conjugating system; Ubiquitin ligase D4A4T0 287155 10q12 rat S20-p 453857 LGTGGGGsPDKSPSA protein stabilization; molecular association, regulation HSC70(INDUCES) 33082318 3 98 9 +CEP83 CCDC41 Cytoskeletal Q9Y592 51134 12q22 human S698-p 14571164 KQLEELGsSGE____ intracellular localization cytoskeletal reorganization 31455668 1 6 0 affects recruitment of TCTN2 and NPHP1, thus regulating ciliogenesis +ATM ATM DNA repair, damage; EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, Ser/Thr (non-receptor); Protein kinase, atypical; Tumor suppressor Q13315 472 11q22.3 human K3016-ac 1968604 VLMRLQEkLKGVEEG enzymatic activity, induced 17923702 1 0 0 +Zbp1 ZBP1 DNA-binding; Motility/polarity/chemotaxis Q9QY24 58203 2|2 H3 mouse K43-ub 1873076608 KKCQVPKkTLNQVLY z-alpha apoptosis, induced 28634194 1 1 0 induces apoptosis due to influenza A virus infection +Phb1 PHB Apoptosis; Cell cycle regulation; Chaperone; Mitochondrial; Motility/polarity/chemotaxis; Nuclear receptor co-regulator; Oncoprotein; Transcription, coactivator/corepressor P67778 18673 11 59.01 cM|11 D mouse Y259-p 6374000 SRSRNITyLPAGQSV molecular association, regulation; intracellular localization signaling pathway regulation FCER1G(INDUCES) 24023254 5 2 0 FCER1G and Syk-mediated signaling, increases antigen-induced mast cell degranulation +Ikzf1 Ikaros C2H2-type zinc finger protein; DNA-binding; Transcription factor Q03267 22778 11 A1|11 7.02 cM mouse S63-p 451348 NVKVETQsDEENGRA activity, inhibited cell cycle regulation DNA(DISRUPTS) 15024069 2 10 4 +Pitpnb PITPNB Lipid-binding P53811 56305 5|5 F mouse S262-p 451299 ETMRKKGsVRGTSAA activity, induced; intracellular localization apoptosis, induced; cell growth, altered 11953429; 15164762; 17683809 5 17 22 +KCNH2 Kv11.1 Channel, potassium; Membrane protein, integral; Membrane protein, multi-pass; Motility/polarity/chemotaxis Q12809 3757 7q36.1 human Y611-p 3496803 GPSIKDKyVTALYFT Ion_trans activity, induced 18617000 1 1 0 +PTTG1 Securin Cell cycle regulation; Oncoprotein O95997 9232 5q33.3 human T66-p 33663901 ATRKALGtVNRATEK Securin protein degradation; ubiquitination; enzymatic activity, induced chromatin organization, altered 24781523 1 1 0 1) Phosphorylation of securing leads to premature activation of separase. 2) Prevention of securin phosphorylation leads to impaired chromosome segregation and thereby leads to DNA damage. +Mpl MPL Membrane protein, integral; Receptor, cytokine Q08351 17480 4 D2.1|4 54.61 cM mouse S543-p 3091407 DTAALSPsKATVTDS activity, induced; phosphorylation cell growth, altered 10918061 1 0 0 tyrosine phosphorylation of JAK2 +Rorc RORC DNA-binding; Nuclear receptor; Transcription factor P51450 19885 3|3 F2.1 mouse S337-p 25308318 VEFAKRLsGFMELCQ Hormone_recep protein degradation; molecular association, regulation; ubiquitination transcription, inhibited ITCH(INDUCES) 36103814 1 0 1 +MVB12A FAM125A Adaptor/scaffold Q96EY5 93343 19p13.11 human S163-p 3950650 VPKPRGLsRDMQGLS DUF2464 protein processing 18005716 1 6 7 inhibition of HIV-1 release and infectivity +Psma3 PSMA3 EC 3.4.25.1; Protease; Proteasome complex P18422 29670 6q24 rat S243-p 451184 AEKYAKEsLKEEDES protein stabilization 14583091 2 19 0 +RORA RORA DNA-binding; Nuclear receptor P35398 6095 15q22.2 human S100-p 1212279800 CKGFFRRsQQSNATY zf-C4 molecular association, regulation; intracellular localization transcription, induced DNA(INDUCES) 30025153; 32686824; 34157297 4 1 0 +Neurod1 NEUROD1 DNA-binding; Transcription factor Q60867 18012 2 C3|2 47.58 cM mouse S266-p 465679 SPLTDCTsPSFDGPL Neuro_bHLH transcription, induced 12810726 1 0 0 +TYMS TYMS Cofactor and Vitamin Metabolism - one carbon pool by folate; DNA repair, damage; EC 2.1.1.45; METHYLTRANSFERASE; Methyltransferase; Mitochondrial; Nucleotide Metabolism - pyrimidine P04818 7298 18p11.32 human T170-p 1875342300 RVIDTIKtNPDDRRI Thymidylat_synt phosphorylation 34845374 1 1 0 reciprocal phosphorylation/O-GlcNAcylation with T306 O-GlcAc site +APP APP iso4 Apoptosis; Cell surface; Membrane protein, integral; Receptor, misc.; Transcription factor P05067-4 351 21q21.3 human S198-p 450331 EESDNVDsADAEEDD intracellular localization 8999878 1 2 0 APP was phosphorylated within the post Golgi as well as on the cell surface. +RCAN1 RCAN1 Inhibitor P53805 1827 21q22.12 human S167-p 456023 FLISPPAsPPVGWKQ Calcipressin activity, induced; protein degradation transcription, altered 12809556; 16126726 7 38 6 increases calcineurin-inhibiting activity of DSCR1; Phosphorylation of MCIP at S108/S112 by MEKK3 is required for activation of calcineurin/NFAT signaling. +Dpysl2 CRMP-2 Microtubule-binding; Motility/polarity/chemotaxis O08553 12934 14 D1|14 34.6 cM mouse S522-p 448082 PASSAKTsPAKQQAP molecular association, regulation transcription, altered DRP1(DISRUPTS); RHOT2(DISRUPTS) 33318403; 34685760 31 49 84 +ADRA2A ADRA2A GPCR, family 1; Membrane protein, integral; Membrane protein, multi-pass; Receptor, GPCR P08913 150 10q25.2 human S375-p 467300 RVGAAKAsRWRGRQN 7tm_1; TM receptor desensitization, altered 11864637 1 0 0 +Rrad RRAD G protein; G protein, monomeric; G protein, monomeric, RGK O88667 56437 8|8 D3 mouse S301-p 4700229 AFRAKSKsCHDLSVL activity, induced; molecular association, regulation CACNA1C(DISRUPTS) 31969708 3 17 0 induces Cav1.2 currents +GRK5 GRK5 EC 2.7.11.16; KINASE; Kinase, protein; Protein kinase, AGC; Protein kinase, Ser/Thr (non-receptor) P34947 2869 10q26.11 human T10-p 50780063 LENIVANtVLLKARE enzymatic activity, inhibited 31786308 1 2 0 +STAT3 STAT3 DNA-binding; Motility/polarity/chemotaxis; Nuclear receptor co-regulator; Transcription factor P40763 6774 17q21.2 human T714-p 3190177 KTKFICVtPTTCSNT transcription, induced 24615012 1 13 11 dual T714/S727 phosphorylation +STAT2 STAT2 DNA-binding; Transcription factor P52630 6773 12q13.3 human T385-p 1869778701 ILTSNQKtLTPEKGQ STAT_bind protein degradation; molecular association, regulation; ubiquitination carcinogenesis, inhibited; cell growth, inhibited; signaling pathway regulation FBXW7(INDUCES) 31843895 1 0 0 by FBXW7 interaction; FBXW7-STAT2 interaction regulate melanoma cell and colony growth +ALDH1A1 ALDH1A1 Apoptosis; Cofactor and Vitamin Metabolism - retinol; EC 1.2.1.36; GAP; GAP, Ras; Oxidoreductase P00352 216 9q21.13 human T267-p 14567868 KSNLKRVtLELGGKS Aldedh protein stabilization; ubiquitination; intracellular localization; protein conformation; enzymatic activity, induced carcinogenesis, induced; cell motility, induced; cell growth, induced; transcription, induced ALDH1A1(DISRUPTS) 28193222 1 10 1 inhibits ubiquitination, induces drug resistance, T267 site ALDHA1A1 increases enzymatic activity, oligomers dissociate to the monomeric form +Pik3ap1 BCAP Adaptor/scaffold Q9EQ32 83490 19|19 C3 mouse Y460-p 449909 PAATEDLyVEMLQAS molecular association, regulation cell differentiation, altered PIK3R1(INDUCES) 18025150 2 0 0 regulate Akt activation and B-cell differentiation through binding to PI3KR1 +CDC25B CDC25B EC 3.1.3.48; Motility/polarity/chemotaxis; Nuclear receptor co-regulator; PHOSPHATASE; Protein phosphatase, dual-specificity P30305 994 20p13 human S230-p 470115 AFAQRPSsAPDLMCL M-inducer_phosp protein degradation; molecular association, regulation; enzymatic activity, inhibited 14-3-3 sigma(INDUCES) 17003105; 21558810; 23840880 5 4 0 protects against proteosome degradation of centrosomal centrin +Arrb2 ARRB2 Adaptor/scaffold Q91YI4 216869 11 B3|11 42.99 cM mouse T383-p 455373 EFDTNYAtDDDIVFE molecular association, regulation; receptor internalization, altered CLTC(DISRUPTS) 12186555 5 3 2 decreases beta2-adrenergic receptor internalization +Hsf2 HSF2 DNA-binding P38533 15500 10|10 B4 mouse K82-sm 2535908 HIESGIIkQERDGPV HSF_DNA-bind molecular association, regulation DNA(INDUCES) 11278381 3 2 0 +SPAG5 SPAG5 Cell cycle regulation Q96R06 10615 17q11.2 human T111-p 460413 PIPQISStPKTSEEA intracellular localization 18055457 1 4 4 required for SPAG5 localization to the spindle apparatus during mitosis +TEX14 TEX14 Cancer Testis Antigen (CTA); KINASE; Kinase, protein; Protein kinase, Other; Protein kinase, Ser/Thr (non-receptor) Q8IWB6 56155 17q22 human S437-p 25158900 QKAATVKsDIYSFSM PK_Tyr_Ser-Thr protein degradation; intracellular localization cell cycle regulation 22405274 1 0 0 +PXN PXN Adaptor/scaffold; Cell adhesion; Cytoskeletal; Motility/polarity/chemotaxis P49023 5829 12q24.23 human S126-p 450227 SFPNKQKsAEPSPTV Paxillin receptor internalization, induced; intracellular localization cell motility, induced; transcription, induced; cytoskeletal reorganization 23549785; 27941878; 35293964 8 28 4 +Wasf1 WAVE1 Cytoskeletal; Motility/polarity/chemotaxis Q8R5H6 83767 10 B1|10 22.07 cM mouse S441-p 7979602 PPGIRPSsPVAVAAL activity, inhibited 20403076 4 0 0 +TNK1 TNK1 EC 2.7.10.2; KINASE; Kinase, protein; Protein kinase, TK; Protein kinase, tyrosine (non-receptor) Q13470 8711 17p13.1 human S502-p 483166 RMKGISRsLESVLSL molecular association, regulation; intracellular localization; enzymatic activity, inhibited; phosphorylation cell growth, inhibited 14-3-3 sigma(INDUCES); 14-3-3 beta(INDUCES); 14-3-3 theta(INDUCES); 14-3-3 zeta(INDUCES); 14-3-3 epsilon(INDUCES); 14-3-3 gamma(INDUCES) 34504101; 36402225 3 27 1 inhibits substrate phosphorylation +SRC Src EC 2.7.10.2; KINASE; Kinase, protein; Oncoprotein; Protein kinase, TK; Protein kinase, tyrosine (non-receptor) P12931 6714 20q11.23 human Y93-p 4251105 VTTFVALyDYESRTE SH3_1 molecular association, regulation; intracellular localization; protein conformation; phosphorylation; enzymatic activity, induced carcinogenesis, induced; cell growth, induced; signaling pathway regulation PXN(DISRUPTS); FAK(DISRUPTS); P130Cas(DISRUPTS); STAT3(DISRUPTS) 37428018 2 3 0 induces phosphorylation at Y419, induces Ras/MAPK, PI3K/Akt, and Stat3 signaling +ATM ATM DNA repair, damage; EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, Ser/Thr (non-receptor); Protein kinase, atypical; Tumor suppressor Q13315 472 11q22.3 human S1891-p 14735942 TTPANLDsESEHFFR carcinogenesis, inhibited 21765463 4 6 0 +TCF21 TCF21 DEACETYLASE; DNA-binding; Deacetylase; Motility/polarity/chemotaxis; Nuclear receptor co-regulator O43680 6943 6q23.2 human K24-sm 56394107 MLECDGLkMDSNKEF protein stabilization; molecular association, regulation; ubiquitination cell cycle regulation; carcinogenesis, inhibited; cell growth, inhibited; transcription, inhibited HDAC1(INDUCES); HDAC2(INDUCES) 27028856 1 0 0 inhibits ubiquitination, induces HDAC1/2 recruitment to promoter through binding to HDAC1/2 +MAPT Tau iso8 ACETYLTRANSFERASE; Acetyltransferase; Cytoskeletal P10636-8 4137 17q21.31 human Y18-p 454024 MEDHAGTyGLGDRKD protein stabilization; molecular association, regulation 28251926 9 1 0 continued kinesin-1 mediated cargo transport, reduces 3RS-Tau?s inhibition of kinesin-1 motility +Smc3 SMC3 Cell cycle regulation; DNA repair, damage Q9CW03 13006 19|19 D2 mouse K113-ac 41420258 KDQYFLDkKMVTKND SMC_N cell cycle regulation 21139566 1 0 1 +Fosl1 FRA1 DNA-binding; Transcription factor P10158 25445 1q43 rat T231-p 50205700 LMTTPSLtPFTPSLV activity, induced transcription, induced 11756554 2 0 0 +Hnrnpk hnRNP K iso2 RNA splicing; RNA-binding; Spliceosome P61979-2 15387 13|13 B1 mouse S116-p 452369 EEGLQLPsPTATSQL intracellular localization 20960454 4 38 22 +CD300LB CD300LB Membrane protein, integral; Receptor, misc. A8K4G0 124599 17q25.1 human Y188-p 975498 EPGEQPIyMNFSEPL activity, induced transcription, altered GRB2(INDUCES) 16920917; 17928527 2 1 0 cytokine production; Interaction with Grb2 required Fyn. +PIK3AP1 BCAP Adaptor/scaffold Q9DDT2 374268 chicken Y423-p 450044 GEEDESVyESMAHLS molecular association, regulation PIK3R1(INDUCES) 11163197 2 0 9 +ARID4A RbBP1 Adaptor/scaffold P29374 5926 14q23.1 human K444-sm 12004424 EMPLTEVkSEPEENI cell cycle regulation; cell growth, inhibited; transcription, inhibited 16479010 1 0 0 +Flna FLNA Actin-binding; Motility/polarity/chemotaxis; Nuclear receptor co-regulator Q8BTM8 192176 X A7.3|X 37.89 cM mouse S2152-p 451357 TRRRRAPsVANIGSH Filamin activity, induced cell motility, induced; cell differentiation, induced; cytoskeletal reorganization 22698694; 34150753 19 80 999 +Lcp1 L-plastin Actin-binding; Motility/polarity/chemotaxis Q61233 18826 14 D3|14 39.63 cM mouse S7-p 455966 _MARGSVsDEEMMEL cytoskeletal reorganization 30248139 1 19 6 sealing ring formation (nascent sealing zone) in osteoclasts, bone resorption +ABI3 ABI3 Adaptor/scaffold Q9P2A4 51225 17q21.32 human S342-p 4755297 ICVTRRYsDGWCEGV SH3_9 molecular association, regulation WAVE2(DISRUPTS); CYFIP1(DISRUPTS) 28978070 1 7 1 +PRMT6 PRMT6 EC 2.1.1.125; METHYLTRANSFERASE; Methyltransferase; Methyltransferase, protein arginine Q96LA8 55170 1p13.3 human R35-m1 41554252 EREAALErPRRTKRE protein stabilization 23866860 1 2 1 automethylated PRTM6 inhibits HIV1 replication +LRRK2 LRRK2 EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, Ser/Thr (non-receptor); Protein kinase, TKL Q5S007 120892 12q12 human T1410-p 10426324 STHPHFMtQRALYLA Roc molecular association, regulation; enzymatic activity, induced LRRK2(INDUCES) 21060682 6 4 0 T1410A mutation has a small effect on protein's dimerization, it reduces GTPase activity of LRRK2 +ARHGAP35 GRF-1 GAP; GAP, Rac/Rho; Motility/polarity/chemotaxis; Transcription factor; Tumor suppressor Q9NRY4 2909 19q13.32 human S1221-p 10406116 RRRNILRsLRRNTKK RhoGAP_pG1_pG2 molecular association, regulation cytoskeletal reorganization 19673492 1 1 1 prevents the association of the protein with acidic phospholipids and modulate the GTPase substrate preference +Gli2 GLI2 C2H2-type zinc finger protein; Oncoprotein; Transcription factor Q0VGT2 14633 1 E2.3|1 52.17 cM mouse S230-p 2677401 LSRKRALsISPLSDA protein stabilization 25825734 3 7 0 +Ddr2 DDR2 EC 2.7.10.1; KINASE; Kinase, protein; Membrane protein, integral; Protein kinase, TK; Protein kinase, tyrosine (receptor) Q62371 18214 1 H3|1 76.84 cM mouse Y739-p 456862 RNLYSGDyYRIQGRA PK_Tyr_Ser-Thr cell differentiation, induced 37245640 2 9 366 +BECN1 beclin 1 Adaptor/scaffold; Autophagy; Membrane protein, peripheral Q14457 8678 17q21.31 human K430-ac 63237402 EQWTKALkFMLTNLK APG6 protein stabilization; molecular association, regulation; acetylation carcinogenesis, inhibited; autophagy, induced; cell growth, induced; apoptosis, inhibited; autophagy, inhibited rubicon(INDUCES) 26008601; 29088823 2 2 0 CK1 phosphorylation primes for Beclin 1 acetylation; aspirin treatment +BAIAP2L1 IRTKS Adaptor/scaffold; Cytoskeletal Q9UHR4 55971 7q21.3-q22.1 human Y274-p 456190 SNVVRKDyDTLSKCS cell motility, induced 21840312 1 9 231 +Prm1 PRM1 Cancer Testis Antigen (CTA); DNA-binding P02319 19118 16 A1|16 5.87 cM mouse S9-p 451410 ARYRCCRsKSRSRCR Protamine_P1 molecular association, regulation; intracellular localization chromatin organization, altered NPM2(INDUCES); HIRA(INDUCES) DNA(DISRUPTS) 32169215 2 1 0 induces protamine-to-histone exchange on DNA +L1CAM NCAM-L1 Cell adhesion; Membrane protein, integral P32004 3897 Xq28 human Y1151-p 466002 KRSKGGKySVKDKED Bravo_FIGEY protein conformation; phosphorylation 19720049 2 0 0 mutation of this site promotes phosphorylation of N-CAML1 Y1176, Y1211, Y1229 and T1172 +Nfatc2 NFAT1 DNA-binding; Transcription factor Q60591 18019 2 H3|2 88.91 cM mouse S215-p 447845 QNIPAHYsPRTSPIM protein stabilization; ubiquitination carcinogenesis, induced; cell growth, induced; transcription, induced; transcription, inhibited 11030334; 21628454 1 1 4 inhibits ubiquitination of NFAT1 residues K684 and K897 +CREB1 CREB DNA-binding; Transcription factor P16220 1385 2q33.3 human S103-p 451810 DSQESVDsVTDSQKR pKID phosphorylation 17209043 5 0 0 mutation to alanine decreases S121 phosphorylation in cells treated with ionizing radiation +PELP1 PELP1 Nuclear receptor co-regulator; Transcription, coactivator/corepressor Q8IZL8 27043 17p13.2 human S477-p 470174 ADALKLRsPRGSPDG NUC202 cell cycle regulation; carcinogenesis, altered; transcription, altered 20807815 1 25 18 +PXN PXN Adaptor/scaffold; Cell adhesion; Cytoskeletal; Motility/polarity/chemotaxis P49023 5829 12q24.23 human S85-p 451054 HQQPQSSsPVYGSSA Paxillin molecular association, regulation; intracellular localization cell motility, induced; cytoskeletal reorganization; cell adhesion, altered talin 1(INDUCES) 14970194; 22761432 2 50 613 haptotactic cell migration induced, induced focal adhesion formation and formation of invasive protrusions +YAP1 YAP1 iso2 Oncoprotein; Transcription, coactivator/corepressor P46937-2 10413 11q22.1 human S128-p 485035 QHVRAHSsPASLQLG molecular association, regulation apoptosis, inhibited; transcription, induced TEAD1(INDUCES) 22308035 8 12 77 YAP phosphorylation is required for anti-apoptotic activity of YAP in cells which are deficient in p73 alpha/beta expression. +TP53 p53 Activator; DNA-binding; Motility/polarity/chemotaxis; Nuclear receptor co-regulator; Transcription factor; Tumor suppressor P04637 7157 17p13.1 human S366-p 455223 PGGSRAHsSHLKSKK activity, induced; protein stabilization; molecular association, regulation carcinogenesis, inhibited; cell growth, inhibited; transcription, inhibited; transcription, altered S100B(DISRUPTS); p53(INDUCES); 14-3-3 epsilon(INDUCES); 14-3-3 gamma(INDUCES); S100A2(DISRUPTS) DNA(INDUCES) 15659650; 18812399; 19819244; 19933256; 21317290; 35902728 5 1 0 +PPARD PPAR-delta DNA-binding; Nuclear receptor A9XAM2 pig K18-ub 62484402 VREEEKKkEVAEAEG transcription, induced 24058710 1 0 0 +Set SET iso2 Apoptosis; DNA replication; DNA-binding; Inhibitor; Nuclear receptor co-regulator; Oncoprotein; Protein phosphatase, regulatory subunit Q9EQU5-2 56086 2|2 B mouse S9-p 6308300 SAPTAKAsKKELNSN intracellular localization 29760653 6 3 0 Tau pathology; translocation from the nucleus to the cytoplasm, cognitive deficits +Gja1 GJA1 Channel, misc.; Membrane protein, integral; Membrane protein, multi-pass; Motility/polarity/chemotaxis P23242 14609 10 B4|10 28.64 cM mouse S328-p 449993 GQAGSTIsNSHAQPF Connexin43 molecular association, regulation; intracellular localization cytoskeletal reorganization; signaling pathway regulation; endocytosis, inhibited TUBB(INDUCES) 16882687; 21527737; 31189653; 36206047 10 13 0 +HK2 HK2 Carbohydrate Metabolism - amino sugar and nucleotide sugar; Carbohydrate Metabolism - fructose and mannose; Carbohydrate Metabolism - galactose; Carbohydrate Metabolism - glycolysis and gluconeogenesis; Carbohydrate Metabolism - starch and sucrose; EC 2.7.1.1; Kinase, other; Mitochondrial P52789 3099 2p12 human T473-p 28704601 QHRARQKtLEHLQLS Hexokinase_1 protein stabilization; intracellular localization; enzymatic activity, induced carcinogenesis, induced; autophagy, induced; cell motility, induced; cell growth, induced; apoptosis, inhibited 29985480; 31435020 6 0 0 +FLT3 FLT3 EC 2.7.10.1; KINASE; Kinase, protein; Membrane protein, integral; Oncoprotein; Protein kinase, TK; Protein kinase, tyrosine (receptor) P36888 2322 13q12.2 human R972-m2 1879733100 CPHTYQNrRPFSREM molecular association, regulation carcinogenesis, induced; cell growth, induced; apoptosis, inhibited GRB2(INDUCES); Btk(NOT_REPORTED); SHP-2(INDUCES) 31217189; 31395602 2 2 0 +HSPA1A HSP70 Chaperone; Heat shock protein; Motility/polarity/chemotaxis P0DMV8 3303 6p21.33 human S418-p 15403914 TALIKRNsTIPTKQT HSP70 apoptosis, inhibited 25900241 1 2 1 +RAF1 RAF1 EC 2.7.11.1; KINASE; Kinase, protein; Oncoprotein; Protein kinase, Ser/Thr (non-receptor); Protein kinase, TKL P04049 5894 3p25.2 human T491-p 447748 IGDFGLAtVKSRWSG PK_Tyr_Ser-Thr enzymatic activity, induced 11447113; 12551923; 12865432 5 0 0 +RIGI RIGI EC 3.6.4.13; Hydrolase O95786 23586 9p21.1 human K164-ub 7761220 ECLLRSDkENWPKTL CARD_2 activity, induced transcription, induced; signaling pathway regulation 19484123; 28948228 2 1 0 regulates RIG-I activation and RIG-I-mediated IFN-B induction and antiviral capacity; induces DDX58-mediated innate antiviral activity +MDH1 MDH1 Carbohydrate Metabolism - citrate (TCA) cycle; Carbohydrate Metabolism - glyoxylate and dicarboxylate; Carbohydrate Metabolism - pyruvate; EC 1.1.1.37; EC 1.1.1.96; Oxidoreductase P11708 396894 pig R230-m1 29429248 FITTVQQrGAAVIKA Ldh_1_C molecular association, regulation; enzymatic activity, inhibited carcinogenesis, inhibited; cell growth, inhibited MDH1(DISRUPTS) 27840030 1 2 2 disrupts dimerization +Lpp LPP Adaptor/scaffold; Cytoskeletal; Motility/polarity/chemotaxis Q8BFW7 210126 16|16 B1 mouse Y245-p 449712 GPSSGQIyGPGPRGY cell cycle regulation; cell motility, altered 18515860 2 13 114 +KCNK3 KCNK3 Channel, potassium; Membrane protein, integral; Membrane protein, multi-pass O14649 3777 2p23.3 human T383-p 2840502 TGLHSLStFRGLMKR activity, inhibited 23229553 3 1 0 peri-operative atrial fibrillation; TASK1 current inhibition +SH3KBP1 SH3KBP1 Adaptor/scaffold; Apoptosis; Motility/polarity/chemotaxis Q96B97 30011 Xp22.12 human S587-p 457025 TAGHRANsPSLFGTE molecular association, regulation DAB1(DISRUPTS) 23178720 1 54 9 +Pin1 PIN1 EC 5.2.1.8; Isomerase; Nuclear receptor co-regulator Q9QUR7 23988 9 A3|9 7.6 cM mouse S113-p 911089201 ESLASQFsDCSSAKA Rotamase enzymatic activity, induced cytoskeletal reorganization 29559586 1 0 0 supports spine numbers and complexity +RBBP8 CtIP EC 3.1.-.-; Transcription, coactivator/corepressor Q99708 5932 18q11.2 human K513-ac 33625702 SQGSETSkNKFRQVT enzymatic activity, induced 24837676 1 1 0 +TRPV1 TRPV1 Channel, cation; Membrane protein, integral; Membrane protein, multi-pass; Receptor, misc. Q8NER1 7442 17p13.2 human S801-p 450017 VPLLREAsARDRQSA receptor desensitization, altered 18701070 21 0 0 +SECISBP2L SECISBP2L Unknown function Q93073 9728 15q21.1 human T573-p 1868832803 IAKLKRPtALKKVIL molecular association, regulation; intracellular localization cell cycle regulation RHOA(DISRUPTS); KIF23(INDUCES) 31314582 1 0 0 +USP28 USP28 DEUBIQUITINASE; EC 3.4.19.12; Protease; Ubiquitin-specific protease Q96RU2 57646 11q23.2 human S495-p 11952927 STSTESSsQDVESTF UCH molecular association, regulation KLHL2(DISRUPTS) 31938050 2 2 1 ATM mediated phosphorylation disrupts inteaction, destabilizing UCK1 +CACNB2 CACNB2 iso2 Channel, calcium Q08289-2 783 10p12.33-p12.31 human T499-p 470081 RGLSRQEtFDSETQE activity, induced apoptosis, induced 20194790 5 8 30 +DVL3 DVL3 Motility/polarity/chemotaxis Q92997 1857 3q27.1 human S311-p 25736748 EINFENMsNDDAVRV PDZ intracellular localization; activity, inhibited transcription, induced 24993822 1 1 1 +Bub1 BUB1 Cell cycle regulation; EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, Other; Protein kinase, Ser/Thr (non-receptor) O08901 12235 2 F1|2 62.1 cM mouse S447-p 20727507 TPCKVQPsPTVHTKE phosphorylation 34013668 2 9 0 CDK1 phosphorylation at S447 primes TTK phosphorylation at T449 +TTN Titin EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, CAMK; Protein kinase, Ser/Thr (non-receptor) Q8WZ42 7273 2q31.2 human K9564-ub 52490400 ERSERDEkEFEELVS protein degradation 26676607 0 1 0 +RAF1 RAF1 EC 2.7.11.1; KINASE; Kinase, protein; Oncoprotein; Protein kinase, Ser/Thr (non-receptor); Protein kinase, TKL P04049 5894 3p25.2 human S289-p 455311 RSHSESAsPSALSSS activity, induced; molecular association, regulation; intracellular localization; enzymatic activity, inhibited; enzymatic activity, induced cell cycle regulation HRas(DISRUPTS) 15664191; 16407412; 9933647 5 10 55 +PTPN11 SHP-2 iso1 EC 3.1.3.48; Motility/polarity/chemotaxis; PHOSPHATASE; Protein phosphatase, tyrosine (non-receptor) Q06124-1 5781 12q24.13 human S189-p 27458516 GGGERFDsLTDLVEH SH2 molecular association, regulation; enzymatic activity, inhibited; phosphorylation GAB1(DISRUPTS); GAB2(DISRUPTS); PRKD1(DISRUPTS) 25802336 1 1 0 enhances phosphorylation of PKD1 +Cited1 CITED1 Nuclear receptor co-regulator P97769 12705 X D|X 45.25 cM mouse S67-p 27937110 VPTSSSGsTSPIGSP CITED intracellular localization cell differentiation, induced 23529225 1 0 0 S63/64/65/67/69/73/79/80/84A mutation in CITED1 inhibits its translocation into the nucleus and osteoblasts differentiation +MYOD1 MyoD DNA-binding; RNA splicing; Transcription factor P15172 4654 11p15.1 human T115-p 452044 ADRRKAAtMRERRRL HLH activity, inhibited 9751114 2 0 0 +MYL9 MRLC1 Contractile; Motility/polarity/chemotaxis P24844 10398 20q11.23 human T10-p 4964102 SKRAKAKtTKKRPQR intracellular localization cytoskeletal reorganization 22136066 5 0 4 +NFIL3 E4BP4 DNA-binding; Transcription factor Q90Z72 395326 chicken S182-p 452016 CISVIKHsPQSSMSD Vert_IL3-reg_TF protein degradation 15182670 1 0 0 +SLC6A4 SERT Membrane protein, integral; Membrane protein, multi-pass; Transporter P31645 6532 17q11.2 human Y142-p 21697922 MELALGQyHRNGCIS SNF activity, induced; protein stabilization 21992875 1 0 0 increases 5-HT uptake +Def6 DEF6 GEF; GEF, Rac/Rho Q8C2K1 23853 17|17 A3.3 mouse Y144-p 479006 MVPDEVEyLLKKLLG activity, induced; intracellular localization cell differentiation, altered; transcription, altered 18976935 1 0 1 +Cttn Cortactin Actin-binding; Cytoskeletal; Motility/polarity/chemotaxis Q60598 13043 7|7 F5 mouse K314-ac 1880005102 GGKYGVQkDRMDKNA HS1_rep molecular association, regulation; acetylation; intracellular localization DIP2A(INDUCES) 31600191 1 0 0 DIP2A regulates spine morphology and synaptic transmission through acetylation of cortactin; Interaction of DIP2A-cortactin is required for acetylated cortactin; acetylation mimetic cortactin rescues the repetitive behaviors in Dip2a KO mice; acetylation alleviated abnormal PSD95 clustering at the spine head in DIP2A KO neurons +ELK1 ELK1 DNA-binding; Transcription factor P19419 2002 Xp11.23 human K35-ub 1878066501 SRDGGEFkLVDAEEV molecular association, regulation transcription, inhibited DNA(DISRUPTS) 30854565 1 1 0 +KDM5A JARID1A DEMETHYLASE; Demethylase; EC 1.14.11.-; Nuclear receptor co-regulator; Nucleolus; Oxidoreductase; Transcription factor P29375 5927 12p13.33 human S287-p 56630503 RQRKGTLsVNFVDLY intracellular localization 27292631 1 0 0 JARID1A recruitment to the promoters of AKT-regulated genes +Gpr35 GPR35 GPCR, family 1; Membrane protein, integral; Membrane protein, multi-pass; Receptor, GPCR Q9ES90 64095 1|1 D mouse S301-p 1876282806 TPHKSQDsQILSLT_ molecular association, regulation; intracellular localization ARR3(INDUCES) 35101446 1 1 0 +Trpc5 TRPC5 Channel, cation; Membrane protein, integral; Membrane protein, multi-pass Q9QX29 22067 X F2|X 65.49 cM mouse T972-p 455597 DGQEEQVtTRL____ receptor desensitization, induced; molecular association, regulation; receptor desensitization, altered Other(DISRUPTS) 15843439; 33933453 2 0 0 required for desensitization after stimulation by carbachol; disrupts interaction with Phosphatidylinositol 4,5-bisphosphate +HSD17B10 HADH2 Amino Acid Metabolism - valine, leucine and isoleucine degradation; EC 1.1.1.178; EC 1.1.1.35; EC 1.1.1.51; Mitochondrial; Oxidoreductase Q99714 3028 Xp11.22 human K105-ac 1877232022 SKTYNLKkGQTHTLE adh_short enzymatic activity, inhibited cell growth, inhibited RG9MTD1(DISRUPTS) 32703935; 32956445 2 0 0 formation of mt-tRNA splicing complex, regulated mitochondrial function, les cell resistance to stress and cell growth ; mt-tRNA splicing complex +EZH2 EZH2 EC 2.1.1.43; METHYLTRANSFERASE; Methyltransferase; Methyltransferase, protein lysine Q15910 2146 7q36.1 human K307-m2 1878271704 HATPNTYkRKNTETA protein stabilization transcription, inhibited 31693890 1 0 0 EZH2 and SMYD2 collectively modulate the invasion of breast cancer cells +HDAC7 HDAC7 DEACETYLASE; Deacetylase; EC 3.5.1.98; Hydrolase Q8WUI4 51564 12q13.11 human S155-p 455620 FPLRKTVsEPNLKLR intracellular localization; phosphorylation cell motility, altered; cytoskeletal reorganization; transcription, altered; cell growth, altered 15623513; 16980613; 18509061; 18617643 9 34 53 important for VEGF-induced aorta ring angiogenesis; nucleo-cytoplasmic shuttling +RIOK2 RIOK2 EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, Ser/Thr (non-receptor); Protein kinase, atypical Q9BVS4 55781 5q15 human S335-p 471042 TKEGSEFsFSDGEVA cell cycle regulation 21880710 1 28 12 +Prkn PARK2 EC 6.3.2.-; EC 6.3.2.19; Ligase; Translation; Translation regulation; UBIQUITIN LIGASE; Ubiquitin conjugating system; Ubiquitin ligase Q9WVS6 50873 17 A1|17 7.8 cM mouse S65-p 25538008 NCDLEQQsIVHIVQR ubiquitin activity, induced autophagy, induced; cell growth, induced 35145192; 35265609; 36217155 34 10 0 induces mitophagy +Dnm1 DYN1 EC 3.6.5.5; Hydrolase; Microtubule-binding; Motility/polarity/chemotaxis; Motor; Vesicle P21575 140694 3p12 rat Y354-p 450400 SGDQIDTyELSGGAR Dynamin_M molecular association, regulation; protein conformation 12011079 1 1 23 Tyrosine phosphorylation promotes DYN1 self assembly. +MAPT Tau iso8 ACETYLTRANSFERASE; Acetyltransferase; Cytoskeletal P10636-8 4137 17q21.31 human K317-me 1883526400 YKPVDLSkVTSKCGS molecular association, regulation cell growth, inhibited; cell differentiation, induced; cytoskeletal reorganization Tau iso8(INDUCES) 35231567 1 0 0 K317 methylation increases tau self-interactions and promotes tau dimerization, favors the maturation of neuronal cells possibly by facilitating the elongation of processes, facilitates axonal elongation, small yet significant decrease in proliferation of HeLa cells but not Neuro-2a cells +DVL3 DVL3 Motility/polarity/chemotaxis Q92997 1857 3q27.1 human T15-p 34668103 YHLDGQEtPYLVKLP DIX intracellular localization 27486244 2 3 0 centrosomal signal for pS697 accumulated throughout the cell cycle, pS280 only in mitotic spindle and not in the interphase centrosome +MRE11 MRE11A Cell cycle regulation; DNA repair, damage; DNA-binding; Deoxyribonuclease P49959 4361 11q21 human S688-p 449207 SKGVDFEsSEDDDDD protein stabilization; molecular association, regulation cell cycle regulation; DNA repair, inhibited PIH1D1(INDUCES) 28436950; 28512243 2 57 7 +Prkaa1 AMPKA1 Autophagy; EC 2.7.11.1; EC 2.7.11.26; EC 2.7.11.27; EC 2.7.11.31; KINASE; Kinase, protein; Protein kinase, CAMK; Protein kinase, Ser/Thr (non-receptor) Q5EG47 105787 15|15 A1 mouse S494-p 4717473 GTATPQRsGSISNYR AdenylateSensor enzymatic activity, inhibited 26797128 3 2 15 +MDC1 MDC1 Cell cycle regulation Q14676 9656 6p21.33 human K45-m2 40190204 SGAHGPEkDFPLHLG molecular association, regulation; ubiquitination DNA repair, altered RNF8(DISRUPTS) 24240613 2 1 0 demethylation promotes ubiquitination +ITGA4 ITGA4 Cell adhesion; Membrane protein, integral; Motility/polarity/chemotaxis; Receptor, misc. P13612 3676 2q31.3 human S1011-p 7705801 FFKRQYKsILQEENR molecular association, regulation 14-3-3 zeta(INDUCES) 19401330 1 2 0 +MAP2K3 MKK3 EC 2.7.12.2; KINASE; Kinase, protein; Protein kinase, STE; Protein kinase, dual-specificity (non-receptor) P46734 5606 17p11.2 human S218-p 448276 ISGYLVDsVAKTMDA Pkinase enzymatic activity, induced transcription, induced; signaling pathway regulation 21878628; 8622669; 9162092 17 21 65 +NFE2 NF-E2 Cytoskeletal; DNA-binding; Transcription factor Q16621 4778 12q13.13 human K368-sm 2293701 FLVPRGTkMEATD__ molecular association, regulation transcription, induced DNA(INDUCES) 16287851 1 0 0 +Runx1 AML1 DNA-binding; Oncoprotein; Transcription factor Q03347 12394 16 C4|16 53.7 cM mouse S276-p 454401 VHPATPIsPGRASGM protein degradation; ubiquitination 24771859 13 11 70 +PRKN PARK2 EC 6.3.2.-; EC 6.3.2.19; Ligase; Translation; Translation regulation; UBIQUITIN LIGASE; Ubiquitin conjugating system; Ubiquitin ligase O60260 5071 6q26 human S9-p 11096954 IVFVRFNsSHGFPVE ubiquitin molecular association, regulation; ubiquitination; intracellular localization; phosphorylation carcinogenesis, inhibited; signaling pathway regulation RIPK3(INDUCES) 23256036; 31358971 3 1 1 binds to RIPK3 disrupting RIPK3-RIPK1 binding, induces RIPK3 ubiquitination, inhibits RIPK3 and MLKL phosphorylation, regulates RIPK3 localization, induces Parkin-RIPK3 pathway; S9, S10, S101 might be priming phosphorylation sites for S65 phosphorylarion +NRF1 NRF1 DNA-binding; Transcription factor Q16656 4899 7q32.2 human S136-p 23255800 QAIVLCIsPSKPNPV Nrf1_DNA-bind molecular association, regulation cell cycle regulation; transcription, altered DNA(DISRUPTS) 31350280 1 13 1 meiotic regulation +JAK2 JAK2 EC 2.7.10.2; KINASE; Kinase, protein; Oncoprotein; Protein kinase, TK; Protein kinase, tyrosine (non-receptor) O60674 3717 9p24.1 human Y1008-p 448408 LPQDKEYyKVKEPGE PK_Tyr_Ser-Thr activity, induced carcinogenesis, induced; cell motility, induced; cell growth, induced; cell adhesion, induced; apoptosis, inhibited; transcription, induced; signaling pathway regulation 22177802; 22508938; 34118143; 34162728; 34380633; 34642304; 34900727; 35296317; 36516775 77 2 16 +Stim1 STIM1 Calcium-binding; Endoplasmic reticulum; Membrane protein, integral P70302 20866 7 E2-E3|7 54.71 cM mouse S575-p 468876 LVEKLPDsPALAKKT molecular association, regulation; protein conformation ORAI1(INDUCES); EB1(INDUCES) 20736304; 23687376 9 69 13 calcium mobilization and EB1-dependent STIM1 multimerization ; regulate store operated calcium entry (SOCE) +EML3 EML3 Q32P44 256364 11q12.3 human T881-p 483690 GAGPAPAtPSRTPSL molecular association, regulation cell cycle regulation; chromatin organization, altered; cytoskeletal reorganization TUBG1(INDUCES); HAUS6(INDUCES); HAUS8(INDUCES) 30723163 1 23 14 important for EML3 interaction with Augmin and gamma-TuRC complexes and leads to microtubule nucleation and mitotic spindle assembly +Actr2 ARP2 Actin-binding; Cytoskeletal; Motility/polarity/chemotaxis P61161 66713 11 A3.1|11 12.88 cM mouse T237-p 36440502 EQKLALEtTVLVESY Actin intracellular localization 28947541 5 0 0 colocalization with F-actin (decreased in aging macrophages) +TNNI3 TNNI3 Actin-binding; Motility/polarity/chemotaxis; Motor P19429 7137 19q13.42 human S199-p 4707844 RKNIDALsGMEGRKK protein stabilization; molecular association, regulation; activity, inhibited ACTA1(DISRUPTS); TPM1(DISRUPTS) 24116014; 25771144 2 5 0 reduced maximal force generation; any alteration on S199 affect the sensitivity of TNNI3 to proteolysis +WASF2 WAVE2 Actin-binding; Motility/polarity/chemotaxis Q9Y6W5 10163 1p36.11 human S497-p 6377639 EFDEDDWsD______ activity, inhibited cytoskeletal reorganization 19012317 1 2 1 +UBA52-RPS27A-UBB-UBC ubiquitin Ubiquitin-like modifier P62988 2p16 human K48-ub 486303 QRLIFAGkQLEDGRT ubiquitin protein degradation; protein stabilization; molecular association, regulation; ubiquitination; intracellular localization; protein conformation cell cycle regulation; carcinogenesis, induced; carcinogenesis, inhibited; cell growth, inhibited; cell motility, inhibited; transcription, induced; transcription, altered; signaling pathway regulation; autophagy, induced; cell differentiation, induced; cell growth, induced; apoptosis, inhibited; cytoskeletal reorganization; transcription, inhibited; cell growth, altered ALDH2(INDUCES); Cezanne(INDUCES); ZO1(INDUCES); ubiquitin(INDUCES); occludin(INDUCES); nsp3-pp1a-pp1ab(INDUCES); TAB2(INDUCES); NPL4(INDUCES); ADRM1(INDUCES); GRP78(INDUCES); PSMD5(INDUCES) 18326498; 18613717; 18724939; 19858201; 19935683; 2174883; 26471729; 29378950; 30647455; 30714168; 30867293; 31042464; 31076633; 31167788; 31346036; 31366726; 31413110; 31451788; 31534008; 31548378; 31796886; 31802035; 31900278; 31937588; 32076268; 32160516; 32164484; 32366851; 32575755; 32845033; 33082516; 33196940; 33565245; 33568778; 34220184; 35064336; 35110531; 35354308; 35474067; 35638730; 35732617; 35770730; 35843886; 35858925; 36115849; 36261549; 36291162; 8576261 109 50 157 +Aqp2 AQP2 Channel, misc.; Membrane protein, integral; Membrane protein, multi-pass; Transporter; Transporter, aquaporin family P56402 11827 15 F1|15 56.13 cM mouse S256-p 449854 REVRRRQsVELHSPQ activity, induced; protein stabilization; molecular association, regulation; intracellular localization; receptor internalization, inhibited; phosphorylation exocytosis, altered; endocytosis, altered 14-3-3 theta(INDUCES); 14-3-3 zeta(INDUCES); ANXA2(DISRUPTS); HSC70(DISRUPTS); ACTG1(DISRUPTS) 16641094; 18606813; 19144687; 19966308; 24876223; 26645691 78 9 0 +HNRNPD hnRNP D0 RNA splicing; RNA-binding Q14103 3184 4q21.22 human K218-m1 58123002 IELPMDNkTNKRRGF RRM_1 molecular association, regulation L3MBTL iso4(INDUCES) 23583077 0 1 0 +EZR Ezrin Cytoskeletal; Motility/polarity/chemotaxis P15311 7430 6q25.3 human Y478-p 454875 PPPPPPVyEPVSYHV molecular association, regulation; intracellular localization; phosphorylation carcinogenesis, induced; cell motility, induced; cell motility, inhibited; cell adhesion, inhibited; signaling pathway regulation; cell growth, induced; cell motility, altered; cytoskeletal reorganization WWOX(INDUCES); Fes(INDUCES); KCTD15(INDUCES) 15623525; 16438931; 18046454; 21666723; 25231728; 27435765; 34375550 10 4 137 +Trpc6 TRPC6 Channel, cation; Membrane protein, integral; Membrane protein, multi-pass Q61143 22068 9 A1|9 2.46 cM mouse T69-p 470868 RLTHRRQtILREKGR activity, inhibited cell motility, inhibited 18617565; 20177073; 20448219; 23814119; 24740790; 36068079 11 2 6 +Rad52 RAD52 DNA repair, damage P43352 19365 6 F1|6 56.86 cM mouse Y105-p 449061 DLNNGKFyVGVCAFV Rad52_Rad22 molecular association, regulation DNA repair, inhibited RAD52(DISRUPTS) 33440161 4 0 0 +PRKD1 PRKD1 Autophagy; EC 2.7.11.13; KINASE; Kinase, protein; Motility/polarity/chemotaxis; Protein kinase, CAMK; Protein kinase, Ser/Thr (non-receptor) Q15139 5587 14q12 human Y95-p 764000 KFPECGFyGMYDKIL molecular association, regulation; enzymatic activity, induced PKCD(INDUCES) 17804414 3 0 0 +H2bc15 H2B DNA-binding P10853 319187 13|13 A3.1 mouse S36-p 449903 RKRSRKEsYSVYVYK Histone transcription, induced 20647423 7 13 47 S37 phosphorylation essential for cell survival in response to metabolic stress. +RAD17 RAD17 Cell cycle regulation O75943 5884 5q13.2 human T633-p 31894301 EESLGEPtQATVPET molecular association, regulation; phosphorylation carcinogenesis, induced; DNA repair, induced; signaling pathway regulation NBS1(INDUCES) 24534091 1 0 0 Phosphorylated RAD17 at T633 but not the T633A mutant, restores phosphorylation of ATM, CHK2 and NBS1. +SLC8B1 SLC24A6 Calcium-binding; Endoplasmic reticulum; Membrane protein, integral; Membrane protein, multi-pass; Transporter; Transporter, SLC family Q6J4K2 80024 12q24.13 human S258-p 50596805 YQRQRRGsLFCPMPV activity, induced 36476859 2 1 0 +DEK DEK DNA replication; DNA-binding; Histone-binding; Oncoprotein; RNA splicing P35659 7913 6p22.3 human T15-p 36122127 AEGEGTPtQPASEKE protein degradation; molecular association, regulation RNA splicing, induced FBXW7(INDUCES) 21282377 1 3 0 regulates tropomyosin alternative splicing +ESR1 ER-alpha DNA-binding; Nuclear receptor; Transcription factor P03372 2099 6q25.1-q25.2 human Y52-p 12620701 DSSKPAVyNYPEGAA Oest_recep protein stabilization carcinogenesis, induced; cell growth, induced; transcription, induced 20101225 1 0 0 +PLAG1 PLAG1 C2H2-type zinc finger protein; DNA-binding; Oncoprotein; Transcription factor Q6DJT9 5324 8q12.1 human K353-sm 3568002 PEKEQPLkGEIESYL intracellular localization cell growth, induced; transcription, inhibited 16207715 1 0 0 +ALDOB ALDOB Carbohydrate Metabolism - fructose and mannose; Carbohydrate Metabolism - glycolysis and gluconeogenesis; Carbohydrate Metabolism - pentose phosphate pathway; EC 4.1.2.13; KINASE; Lyase P79226 100328925 rabbit Y362-p 451309 QSLFTASyTY_____ Glycolytic enzymatic activity, inhibited 2275541 1 0 1 +MBD4 MBD4 Apoptosis; DNA repair, damage; Deoxyribonuclease; EC 3.2.2.- O95243 8930 3q21.3 human S262-p 22730000 SGFVQSDsKRESVCN enzymatic activity, induced DNA repair, induced 19829383 1 0 0 +CKMT2 CKMT2 Amino Acid Metabolism - arginine and proline; EC 2.7.3.2; Kinase, other; Mitochondrial P17540 1160 5q14.1 human Y368-p 478453 TAAVADVyDISNIDR ATP-gua_Ptrans enzymatic activity, induced transcription, induced; signaling pathway regulation 34095014 1 5 96 induces PGC-1a/estrogen-related receptor-a pathway +Dbnl DBNL Actin-binding; Motility/polarity/chemotaxis Q62418 13169 11 A1|11 3.87 cM mouse Y340-p 450090 QTEEEPTyEVPPEQD cell motility, induced; cytoskeletal reorganization; cell motility, inhibited 22303001; 30504273 4 1 27 cell migration to CP; extracellular matrix degradation, inhibits invasive cell migration +FOXO3 FOXO3A Autophagy; DNA-binding; Oncoprotein; Transcription factor O43524 2309 6q21 human K259-ac 460594 VSMDNSNkYTKSRGR protein stabilization; molecular association, regulation; ubiquitination apoptosis, induced; transcription, induced JNK1(INDUCES); SKP2(DISRUPTS) 21841822; 27669435 5 1 0 +MLYCD MLYCD Carbohydrate Metabolism - propanoate; EC 4.1.1.9; Lyase; Other Amino Acids Metabolism - beta-alanine O95822 23417 16q23.3 human Y405-p 41196501 LMRLCAWyLYGEKHR MCD protein conformation; enzymatic activity, induced 26004805 1 0 0 +SLC12A2 NKCC1 Membrane protein, integral; Membrane protein, multi-pass; Transporter; Transporter, SLC family P55011 6558 5q23.3 human T203-p 467235 HQHYYYDtHTNTYYL AA_permease_N activity, induced; enzymatic activity, induced 16669787; 22032326 11 1 0 +CASP8 CASP8 Apoptosis; EC 3.4.22.61; Protease Q14790 841 2q33.1 human T263-p 21258500 SIRDRNGtHLDAGAL Peptidase_C14 protein degradation; ubiquitination apoptosis, inhibited 21183680 2 1 0 +Smad3 SMAD3 DNA-binding; Nuclear receptor co-regulator; Transcription factor Q8BUN5 17127 9|9 C mouse S423-p 448335 SPSIRCSsVS_____ molecular association, regulation; intracellular localization carcinogenesis, induced; cell growth, induced; cell motility, induced; cell growth, inhibited; cell differentiation, induced; transcription, induced SMAD4(INDUCES) DNA(INDUCES) 30042129; 32122971; 34799661; 37350664 39 0 5 +CIP2A CIP2A Membrane protein, integral Q8TCG1 57650 3q13.13 human S904-p 482834 NPETVNLsI______ molecular association, regulation; intracellular localization cell cycle regulation; cytoskeletal reorganization 14-3-3 eta(INDUCES) 28935709; 36255265 2 11 0 MTOC localization +ESR1 ER-alpha DNA-binding; Nuclear receptor; Transcription factor P03372 2099 6q25.1-q25.2 human S118-p 448101 LHPPPQLsPFLQPHG Oest_recep activity, induced; protein degradation; acetylation; molecular association, regulation; phosphorylation carcinogenesis, induced; carcinogenesis, altered; cell growth, induced; transcription, induced; signaling pathway regulation; transcription, altered; cell growth, altered Src(INDUCES); SRC-2(INDUCES); TCF20(INDUCES); CBP(INDUCES); ERK2(INDUCES); SRC-3(INDUCES); PPP5C(INDUCES); SF3A1(INDUCES); P38A(INDUCES) DNA(INDUCES) 11108261; 11139588; 12093745; 12714702; 14764652; 15059947; 15461668; 15528270; 15778291; 15808510; 15831449; 15879307; 15919818; 16076840; 16113102; 16452229; 17068199; 17615152; 18372406; 19169277; 19339517; 19887647; 19940281; 23390529; 23850489; 23861392; 25531331; 27748765; 28423697; 31120927; 33542078; 34711683; 34810200; 36516775; 36915147; 37285115 93 2 0 +Mcl1 MCL1 Apoptosis; Channel, misc.; Inhibitor; Membrane protein, integral; Mitochondrial P97287 17210 3 F2.1|3 40.74 cM mouse K117-ub 10843917 CEPEAIGkRPAVLPL protein degradation; molecular association, regulation; ubiquitination autophagy, induced beclin 1(DISRUPTS) 28053206 2 2 10 +HAUS8 HAUS8 Cell cycle regulation Q9BT25 93323 19p13.11 human S131-p 20609207 SKKPESTsFSAPRKK intracellular localization cell cycle regulation; apoptosis, inhibited 21690413 1 3 0 localization to the spindle +Pou5f1 Oct4 DNA-binding; Transcription factor P20263 18999 17 B1|17 18.69 cM mouse K137-ub 15496419 QDMKALQkELEQFAK Pou protein degradation 32895487 1 0 1 +Nfe2l2 NRF2 DNA-binding; Transcription factor O54968 83619 3q23 rat S40-p 450082 SREVFDFsQRQKDYE activity, induced; molecular association, regulation; intracellular localization transcription, induced; transcription, altered KEAP1(DISRUPTS); p21Cip1(INDUCES) 12198130; 35842499 33 0 0 +Mark2 MARK2 EC 2.7.11.1; EC 2.7.11.26; KINASE; Kinase, protein; Protein kinase, CAMK; Protein kinase, Ser/Thr (non-receptor) O08679 60328 1q43 rat T208-p 449999 TFGNKLDtFCGSPPY Pkinase enzymatic activity, induced 14517247; 9108484 11 48 47 +NOTCH1 Notch 1 Membrane protein, integral; Motility/polarity/chemotaxis; Oncoprotein; Receptor, misc.; Transcription factor P46531 4851 9q34.3 human S2513-p 35483201 EHPFLTPsPESPDQW protein degradation; molecular association, regulation; ubiquitination carcinogenesis, inhibited FBXW7(INDUCES) 25344755 1 1 0 +ADRB2 ADRB2 GPCR, family 1; Membrane protein, integral; Membrane protein, multi-pass; Receptor, GPCR P07550 154 5q32 human S411-p 457444 RNCSTNDsLL_____ molecular association, regulation; protein conformation NHERF(DISRUPTS) 10499588; 21868357 5 1 0 +ANAPC1 APC1 Cell cycle regulation; Ubiquitin conjugating system Q9H1A4 64682 2q13 human S372-p 483446 GVQRFNIsSHNQSPK activity, induced 27120157 1 11 0 +RCHY1 RCHY1 EC 6.3.2.-; EC 6.3.2.19; Nuclear receptor co-regulator; UBIQUITIN LIGASE; Ubiquitin conjugating system; Ubiquitin ligase Q96PM5 25898 4q21.1 human T217-p 27971903 PSEYQNMtVDILCND zinc_ribbon_6 ubiquitination; activity, inhibited transcription, inhibited 23603988 1 0 0 self-ubiquitination, may contribute to p53-inhibition of transcriptional elongation of HIV-LTR +Map2 MAP2 iso3 Cytoskeletal; Motility/polarity/chemotaxis P15146-3 25595 9q32 rat K316-ac 62495512 DLKNVKSkIGSTDNI Tubulin-binding cytoskeletal reorganization 28002468 1 1 0 +PLK1 PLK1 EC 2.7.11.21; KINASE; Kinase, protein; Protein kinase, Other; Protein kinase, Ser/Thr (non-receptor) P53350 5347 16p12.2 human K413-me 1877571001 IPIFWVSkWVDYSDK enzymatic activity, inhibited cell cycle regulation; cell growth, inhibited 30622182 1 1 0 +CTNNA1 CTNNA1 Actin-binding; Motility/polarity/chemotaxis P35221 1495 5q31.2 human Y177-p 457896 EQDLGIQyKALKPEV Vinculin activity, induced; molecular association, regulation APC(DISRUPTS) 24240237 1 14 576 enhances B-catenin transactivation +BCL2L1 Bcl-xL Apoptosis; Autophagy; Membrane protein, integral; Mitochondrial Q07817 598 20q11.21 human T47-p 448163 GTESEMEtPSAINGN cell cycle regulation; apoptosis, altered; apoptosis, induced CDK1(DISRUPTS) 10617621; 17369848 4 0 0 A peptide surrounding T47 and S62 phosphorylation sites impeded inhibition of CDK1. apoptotoc function of bcl-xl was not affected. +CEACAM1 CEACAM1 iso8 Cell adhesion; Immunoglobulin superfamily; Membrane protein, integral; Motility/polarity/chemotaxis P13688-8 634 19q13.2 human S459-p 3439800 LHFGKTGsSGPLQ__ phosphorylation cell differentiation, altered 17546042 3 1 0 FAK Y397 phosphorylation +DDX21 DDX21 EC 3.6.4.13; Helicase; Nucleolus; RNA processing; RNA-binding Q9NR30 9188 10q22.1 human K137-ac 41518316 PKKMKKEkEMNGETR enzymatic activity, inhibited transcription, inhibited 28790157 1 1 0 Inhibits DDX21 helicase activity, impairs genomic stability, R-loop mediated stalling of RNA polymerase +Ahcyl1 AHCYL1 Amino Acid Metabolism - cysteine and methionine; EC 3.3.1.1; Hydrolase; Other Amino Acids Metabolism - selenoamino acid Q80SW1 229709 3 F2.3|3 46.83 cM mouse T72-p 467248 RSISQSStDSYSSAA molecular association, regulation IP3R1(INDUCES) 16793548 1 0 1 binding to IP3R1 supresses its binding to IP3 and inhibits IP3-induced calcium release +Crem CREM DNA-binding; Transcription factor P27699 12916 18|18 A1 mouse S284-p 450065 QGVVMAAsPGSLHSP activity, inhibited transcription, altered 8114763 3 14 2 +Gata1 GATA1 DNA-binding; Transcription factor P17679 14460 X A1.1|X 3.59 cM mouse S49-p 451233 DAASSSTsPNAATAA protein degradation; acetylation; ubiquitination; phosphorylation DNA(INDUCES) 16858405 2 0 0 Phosphorylation and acetylation cause the degradation of acetylated GATA-1; DNA binding is required for MAPK-dependent phosphorylation +kif2c KIF2C Cancer Testis Antigen (CTA); Microtubule-binding; Motility/polarity/chemotaxis; Motor Q91636 380006 frog S719-p 3545002 LQVEEQAsKQISKKK intracellular localization cytoskeletal reorganization 18434591 2 0 0 facilitates bipolar spindle formation +MYC Myc DNA-binding; Nucleolus; Oncoprotein; Transcription factor P01106 4609 8q24.21 human K341-ub 40850501 YPAAKRVkLDSVRVL Myc_N protein degradation; ubiquitination 25944903 1 1 0 degradation induced by FBXO32 +DLX3 DLX3 DNA-binding; Transcription factor O60479 1747 17q21.33 human K112-sm 25344508 AQDPVSVkEEPEAEV transcription, induced 21268066 1 0 0 +ESR1 ER-alpha DNA-binding; Nuclear receptor; Transcription factor P03372 2099 6q25.1-q25.2 human S106-p 448100 PLNSVSPsPLMLLHP Oest_recep activity, induced; molecular association, regulation carcinogenesis, induced; cell motility, induced; cell growth, induced; transcription, induced; transcription, altered Src(INDUCES); SRC-2(INDUCES); SRC-3(INDUCES); CBP(INDUCES) DNA(INDUCES) 11108261; 12714702; 16076840; 18372406; 23861392; 25531331; 26522726; 33542078 25 1 0 +KRAS KRas G protein; G protein, monomeric; G protein, monomeric, Ras; Motility/polarity/chemotaxis; Oncoprotein P01116 3845 12p12.1 human Y32-p 15228779 QNHFVDEyDPTIEDS Ras molecular association, regulation; protein conformation; activity, inhibited; phosphorylation signaling pathway regulation BRAF(DISRUPTS) 30644389; 34725361 2 5 8 regulates MAPK signaling +RIGI RIGI EC 3.6.4.13; Hydrolase O95786 23586 9p21.1 human T770-p 17484200 DSILRLQtWDEAVFR molecular association, regulation; enzymatic activity, inhibited RIGI(DISRUPTS) 21068236 2 2 0 dephosphorylation of T770, S855, S854 stimulates multimer formation; +VIM Vimentin Cytoskeletal; Motility/polarity/chemotaxis P08670 7431 10p13 human S412-p 451764 EGEESRIsLPLPNFS protein stabilization 36393840 3 35 11 +Atf1 ATF-1 Transcription factor P81269 11908 15|15 F1 mouse S41-p 15725600 SLSESEEsQDSSDSI molecular association, regulation cell growth, induced; transcription, induced HSF1(INDUCES) 25312646 2 0 0 HSP70 expression, increases cell survival +RBBP8 CtIP EC 3.1.-.-; Transcription, coactivator/corepressor Q99708 5932 18q11.2 human T315-p 4766297 FSDSTSKtPPQEELP protein degradation; molecular association, regulation; ubiquitination; enzymatic activity, induced; phosphorylation DNA repair, altered PIN1(INDUCES) 23623683; 24837676 2 13 1 inhibits phosphorylation of RPA2 +Lpcat1 LPCAT1 ACETYLTRANSFERASE; Acetyltransferase; EC 2.3.1.23; EC 2.3.1.67; Endoplasmic reticulum; Membrane protein, integral Q3TFD2 210992 13|13 C1 mouse S178-p 17533100 RPVFVSRsDQDSRRK Acyltransferase protein degradation; ubiquitination 21068446 1 0 0 +Git1 GIT1 GAP; GAP, ARF; Motility/polarity/chemotaxis Q68FF6 216963 11|11 B5 mouse Y330-p 15702200 FLPVNPEySATRNQG molecular association, regulation transcription, induced; signaling pathway regulation ERK2(INDUCES); ERK1(INDUCES) 22797318 4 0 0 VEGF expression and fracture healing +RPS6 S6 Translation P62753 6194 9p22.1 human S244-p 448095 LRASTSKsESSQK__ carcinogenesis, induced; carcinogenesis, inhibited; apoptosis, induced; apoptosis, inhibited; autophagy, inhibited; signaling pathway regulation 34762647; 36149602; 36715448; 37624695 108 34 561 +AGO2 AGO2 EC 3.1.26.n2; RNA processing; RNA-binding Q9UKV8 27161 8q24.3 human S387-p 472450 SKLMRSAsFNTDPYV ArgoL2 molecular association, regulation; enzymatic activity, inhibited; intracellular localization exocytosis, inhibited; RNA stability, inhibited; translation, inhibited TNRC6A(INDUCES); LIMD1(INDUCES) 18476811; 23603119; 27117408; 28683311; 30154469; 34117353 8 22 20 miRNA-mediated repression, downregulating cleavage of endogenous miRNA-targeted mRNAs, P body localization of Ago2; recruitmentof miR-4312 and competes HuR to bind to IL-8 transcrip; inhibits Ago2 association with multivesicular endosomes (MVEs), and diminishes secretion into exosomes +ANPEP CD13 EC 3.4.11.2; Membrane protein, integral; Other Amino Acids Metabolism - glutathione; Protease; Receptor, misc. P15144 290 15q26.1 human S43-p 1870824600 EKNKNANsSPVASTT molecular association, regulation 14-3-3 sigma(INDUCES) 33109610 1 0 0 +HAUS8 HAUS8 Cell cycle regulation Q9BT25 93323 19p13.11 human T130-p 7322606 ISKKPEStSFSAPRK intracellular localization cell cycle regulation; apoptosis, inhibited 21690413 1 1 0 localization to the spindle +GAPDH GAPDH Carbohydrate Metabolism - glycolysis and gluconeogenesis; EC 1.2.1.12; Oxidoreductase P04406 2597 12p13.31 human K117-ac 474648 AHLQGGAkRVIISAP intracellular localization 20601085 1 0 127 nuclear translocation +NCF1 p47phox EC 1.-.-.-; Oxidoreductase P14598 653361 7q11.23 human S345-p 451727 QARPGPQsPGSPLEE activity, induced; molecular association, regulation; intracellular localization; enzymatic activity, induced; phosphorylation cell growth, induced; signaling pathway regulation ROCK2(INDUCES) 16778989; 22460559; 31736979; 31811262; 33388549 23 7 0 +LTB4R LTB4R GPCR, family 1; Membrane protein, integral; Membrane protein, multi-pass; Receptor, GPCR Q15722 1241 14q12 human T315-p 4700736 TGSEASStRRGGSLG receptor internalization, induced; phosphorylation signaling pathway regulation 22707565; 30131369 2 2 0 phosphorylation of LTB4R basal phosphorylation site; enhanced ligand-induced internalization ; chemotaxis, B-hexisaminidase release, regulates LTB4R function +Irf3 IRF3 DNA-binding; Transcription factor P70671 54131 7|7 B3 mouse K152-sm 3278900 GLILGPLkDEGSSDL transcription, inhibited 18635538 2 0 0 +MYC Myc DNA-binding; Nucleolus; Oncoprotein; Transcription factor P01106 4609 8q24.21 human S96-p 28850303 YVAVTPFsLRGDNDG Myc_N carcinogenesis, inhibited; transcription, inhibited 24030976 1 2 0 +Sik1 SIK EC 2.7.11.1; KINASE; Kinase, protein; Motility/polarity/chemotaxis; Protein kinase, CAMK; Protein kinase, Ser/Thr (non-receptor); Tumor suppressor Q9R1U5 59329 20p12 rat S186-p 2560900 PLSTWCGsPPYAAPE Pkinase molecular association, regulation; enzymatic activity, induced 14-3-3 beta(INDUCES) 18348280 2 0 0 important for TORC2 phosphorylation and activation +PIK3C2A PIK3C2A Autophagy; Carbohydrate Metabolism - inositol phosphate; EC 2.7.1.154; KINASE; Kinase, lipid; Motility/polarity/chemotaxis O00443 5286 11p15.1 human S259-p 449059 KVSNLQVsPKSEDIS protein degradation; protein conformation 12719431 1 44 3 +TRIM32 TRIM32 EC 6.3.2.-; EC 6.3.2.19; Ligase; UBIQUITIN LIGASE; Ubiquitin conjugating system; Ubiquitin ligase Q13049 22954 9q33.1 human K247-ac 1873117010 DYFLAKIkQADVALL protein degradation; intracellular localization autophagy, induced 33999923 1 0 0 +HIPK2 HIPK2 EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, CMGC; Protein kinase, Ser/Thr (non-receptor) Q9H2X6 28996 7q34 human T119-p 28847903 HNLMRRStVSLLDTY protein stabilization; molecular association, regulation; phosphorylation; enzymatic activity, induced PPM1D(DISRUPTS) 23871434 1 0 0 increase protein stabilization and reduce phosphorylation of WIP1 +KCNMA1 KCNMA1 Channel, potassium; Endoplasmic reticulum; Membrane protein, integral; Membrane protein, multi-pass Q12791 3778 10q22.3 human S978-p 456598 PPGMDRSsPDNSPVH activity, induced 11078709 1 4 0 +Cd19 CD19 Cell surface; Membrane protein, integral P25918 12478 7 F3|7 69.01 cM mouse Y522-p 447639 HEEDADSyENMDKSD activity, induced; molecular association, regulation cell differentiation, altered PIK3R1(INDUCES) 12387743; 18025150 8 3 18 regulate Akt activation and B-cell differentiation through binding to PI3KR1 +GSK3B GSK3B EC 2.7.11.1; EC 2.7.11.26; KINASE; Kinase, protein; Protein kinase, CMGC; Protein kinase, Ser/Thr (non-receptor) P49841 2932 3q13.33 human T390-p 452320 RIQAAAStPTNATAA enzymatic activity, induced signaling pathway regulation 18451303; 21303975 6 15 13 epithelial to mesenchymal transition (EMT) +PPP1R12A MYPT1 Motility/polarity/chemotaxis; PHOSPHATASE; Protein phosphatase, regulatory subunit O14974 4659 12q21.2-q21.31 human T577-gl 1868585004 TTSTPTVtSAAGLQK molecular association, regulation; phosphorylation cell cycle regulation PLK1(DISRUPTS) 32295844 1 1 0 inhibits CDK1-dependent phosphorylation at MYPT1 S473, regulates mitotic progression and centrosome integrity +XRCC2 XRCC2 O43543 7516 7q36.1 human S247-p 482708 FFSKQDDsQSSNQFS Rad51 DNA repair, altered 30566856 1 1 0 XRCC2 phosphorylation is involved in regulation of fork progression (slowing) during dNTP alterations +Kat5 Tip60 ACETYLTRANSFERASE; Acetyltransferase; EC 2.3.1.48; Nuclear receptor co-regulator; Nucleolus Q8CHK4 81601 19|19 A mouse S86-p 448826 TKNGLPGsRPGSPER apoptosis, induced 25858503 7 31 5 +FUS hnRNP P2 DNA-binding; Nuclear receptor co-regulator; Oncoprotein; RNA splicing; RNA-binding; SUMO LIGASE P35637 2521 16p11.2 human S462-p 18801758 PGGGPGGsHMGGNYG molecular association, regulation hnRNP P2(DISRUPTS) 35753345 1 7 1 +PEBP1 RKIP Lipid-binding; Protein kinase, regulatory subunit P30086 5037 12q24.23 human S153-p 448755 RGKFKVAsFRKKYEL PBP molecular association, regulation; receptor desensitization, altered; intracellular localization; receptor internalization, altered; phosphorylation RAF1(DISRUPTS); GRK2(INDUCES) 14654844; 17170028; 36805338 9 16 1 +MITF MITF iso9 DNA-binding; Oncoprotein; Transcription factor O75030-9 4286 3p13 human K182-sm 3590701 PANLPNIkRELTACI transcription, inhibited 15507434 3 1 0 +SLX4 SLX4 DNA repair, damage; Deoxyribonuclease Q8IY92 84464 16p13.3 human T1544-p 1880104206 QKPEGLEtPKGANRK molecular association, regulation; protein conformation MUS81(INDUCES) 36288699 1 1 0 +TP53BP2 53BP2 Transcription, coactivator/corepressor Q13625 7159 1q41 human S827-p 30995203 NSDMPAPsPGLDYEP intracellular localization apoptosis, induced; transcription, induced 24312625 1 1 0 necessary for Ras-induced translocation to the cytosol and nucleus, p53 mediated transcription and pro-apoptotic activity +GRIN2A NMDAR2A Channel, ligand-gated; Membrane protein, integral; Membrane protein, multi-pass Q12879 2903 16p13.2 human Y1292-p 4109565 RISRQHSyDNIVDKP NMDAR2_C activity, induced 33037073 3 1 16 leptin-induced beta-cell membrane potentiation +FPR1 FPR1 GPCR, family 1; Membrane protein, integral; Membrane protein, multi-pass; Motility/polarity/chemotaxis; Receptor, GPCR P21462 2357 19q13.41 human S328-p 450847 ERALTEDsTQTSDTA molecular association, regulation; receptor desensitization, altered; receptor internalization, altered ARRB2(INDUCES) 10514456; 16622009 3 2 0 +ABL2 Arg EC 2.7.10.2; KINASE; Kinase, protein; Oncoprotein; Protein kinase, TK; Protein kinase, tyrosine (non-receptor) P42684 27 1q25.2 human Y272-p 456540 KCNKPTVyGVSPIHD enzymatic activity, induced 34144039 3 5 3 +Rb1 Rb Nuclear receptor co-regulator; Oncoprotein; Transcription, coactivator/corepressor; Tumor suppressor P13405 19645 14 38.73 cM|14 D3 mouse S786-p 17551329 PRSPYKFsSSPLRIP Rb_C cell cycle regulation; transcription, inhibited 9671466 1 1 0 transcriptional downregulation of the E2F-1, E2F-2, dihydrofolate reductase, thymidine kinase, c-myc, proliferating-cell nuclear antigen, p107, and p21/Cip1 genes +XPO1 Exportin-1 Karyopherin; Nuclear export; Nuclear import; Nucleolus O14980 7514 2p15 human S1055-p 453528 EKHKRQMsVPGIFNP activity, induced; intracellular localization autophagy, induced; signaling pathway regulation 31544310 1 8 69 Hippo signaling pathway; regulates subcellular localization (nuclear exit) of NDR1 (aka STK38), Beclin1 and YAP1 +ABI2 Abi-2 Adaptor/scaffold; Motility/polarity/chemotaxis Q9NYB9 10152 2q33.2 human S183-p 4710620 PPTQKPPsPPMSGKG protein stabilization carcinogenesis, induced; cell motility, induced; cytoskeletal reorganization 37042842 1 31 4 +DGCR8 DGCR8 Nucleolus; RNA processing; RNA-binding Q8WYQ5 54487 22q11.21 human S123-p 36129171 KDVKISVsFTESCRS protein stabilization 24239349 0 2 0 +NEK2 NEK2 EC 2.7.11.1; KINASE; Kinase, protein; Nucleolus; Protein kinase, Other; Protein kinase, Ser/Thr (non-receptor) P51955 4751 1q32.3 human T175-p 12574603 HDTSFAKtFVGTPYY Pkinase enzymatic activity, induced 17197699 1 2 0 +PTPRA PTPRA iso6 EC 3.1.3.48; Membrane protein, integral; Motility/polarity/chemotaxis; PHOSPHATASE; Receptor protein phosphatase, tyrosine P18433-2 5786 20p13 human S204-p 447612 PLLARSPsTNRKYPP molecular association, regulation; phosphorylation; enzymatic activity, induced cell growth, altered PIK3CB(INDUCES); Src(INDUCES); PKCD(INDUCES); GRB2(DISRUPTS) 11676480; 11923305; 23532252 6 3 1 promotes PTPRA tyrosine phosphorylation +RGS5 RGS5 GAP; GAP, RGS O15539 8490 1q23.3 human S166-p 482845 HALMEKDsLPRFVRS RGS activity, induced; molecular association, regulation G-alpha 13(DISRUPTS) 17540411 1 0 0 increase intracellular Ca2+; GTPase activating function +Cttn Cortactin Actin-binding; Cytoskeletal; Motility/polarity/chemotaxis Q60598 13043 7|7 F5 mouse S418-p 447701 IEDRPPSsPIYEDAA cell cycle regulation; cell motility, altered 18515860 15 90 197 +DCBLD2 DCBLD2 Cell adhesion; Membrane protein, integral Q96PD2 131566 3q12.1|3 human Y621-p 454599 LQADSAEyAQPLVGG molecular association, regulation CRKL(INDUCES) 23770091 2 17 87 +CCDC6 CCDC6 Apoptosis; Cytoskeletal; Oncoprotein Q16204 8030 10q21.2 human T427-p 4790792 PDKFKRPtPPPSPNT protein degradation; molecular association, regulation; phosphorylation cell cycle regulation; DNA repair, inhibited FBXW7(INDUCES) 23108047; 25885523; 35964058 3 1 1 inhibits H2AX phosphorylation +SET SET iso2 Apoptosis; DNA replication; DNA-binding; Inhibitor; Nuclear receptor co-regulator; Oncoprotein; Protein phosphatase, regulatory subunit Q01105-2 6418 9q34.11 human S93-p 19009801 FVNHPQVsALLGEED NAP receptor desensitization, induced; molecular association, regulation; phosphorylation signaling pathway regulation PPP2CA(INDUCES) 21419339 2 1 0 beta-2AR phosphorylation and signaling +PKD2L1 PKD2L1 Channel, cation; Membrane protein, integral; Membrane protein, multi-pass; Motility/polarity/chemotaxis Q9P0L9 9033 10q24.31 human T39-p 59032202 HGTLRVCtISSTGPL activity, inhibited 27754867 1 0 0 channel activity regulated independently of palmitoylation +PSIP1 LEDGF Motility/polarity/chemotaxis; Transcription, coactivator/corepressor O75475 11168 9p22.3 human K254-sm 13875715 EPDKKEGkKEVESKR protein degradation transcription, inhibited 20382164 1 0 0 +SLC12A5 KCC2 Membrane protein, integral; Membrane protein, multi-pass; Transporter; Transporter, SLC family Q9H2X9 57468 20q13.12 human T929-p 10045603 SAYTYEKtLVMEQRS SLC12 activity, inhibited 19665974 7 4 0 +FOXM1 FOXM1 DNA-binding; Transcription factor Q08050 2305 12p13.33 human S638-p 10897610 KVGGLDFsPVQTSQG protein stabilization transcription, induced 22094256 2 6 0 +RBM39 RNPC2 Nuclear receptor co-regulator; RNA-binding; Spliceosome Q14498 9584 20q11.22 human Y95-p 3196190 DRRFRGRyRSPYSGP transcription, induced 27018250 1 15 12 expression of ER (or PR) responsive genes +Oprm1 MOR-1 GPCR, family 1; Membrane protein, integral; Membrane protein, multi-pass; Receptor, GPCR P33535 25601 1q11 rat T370-p 447785 STRVRQNtREHPSTA molecular association, regulation; receptor desensitization, altered; receptor internalization, altered; phosphorylation ARR3(INDUCES); ARRB2(INDUCES) 11278523; 12860981; 18558479; 23106126 19 5 0 +KRT18 K18 Cytoskeletal; Nucleolus P05783 3875 12q13.13 human S30-gl 6778602 SYGARPVsSAASVYA phosphorylation apoptosis, inhibited 20729838 3 0 0 K18?Gly? mutation alters protein kinase phosphorylation and promotes apoptosis in response to STZ treatment; Akt1 Thr 308 phosphorylation increased 12 h after STZ treatment in livers of mice expressing wild-type K18, but in K18?Gly? inhibits Akt1 Thr 308 phosphorylation; glycosylation promotes th the phosphorylation and activation of cell-survival kinases +IWS1 IWS1 Transcription factor Q96ST2 55677 2q14.3 human T721-p 1851496 QRRRMNStGGQTPRR molecular association, regulation; intracellular localization carcinogenesis, induced; RNA splicing, induced; cell motility, induced THOC4(DISRUPTS); SPT6(DISRUPTS) 24462114 1 4 79 recruitment of SetD2 to RNA Pol II elongation complex, regulates alternative splicing +Sox2 SOX2 Cell development/differentiation; DNA-binding; Transcription factor P48432 20674 3 A3|3 16.93 cM mouse T118-p 17490601 KYRPRRKtKTLMKKD SOXp activity, induced; protein stabilization transcription, induced 20945330 2 0 0 plays a crucial role in somatic cell reprogramming +CHEK2 Chk2 EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, CAMK; Protein kinase, Ser/Thr (non-receptor); Tumor suppressor O96017 11200 22q12.1 human T378-gl 1872610001 HSKILGEtSLMRTLC Pkinase protein stabilization carcinogenesis, induced; cell growth, induced 33690219 1 0 0 +RAB29 RAB29 G protein; G protein, monomeric; G protein, monomeric, Rab O14966 8934 1q32.1 human S72-p 396518800 AGQERFTsMTRLYYR Ras activity, inhibited 29212815 2 0 0 Rab29 phosphorylation may decrease its ability to activate LRRK2 +AFAP1 AFAP Adaptor/scaffold Q8N556 60312 4p16.1 human Y94-p 3891001 SSLPEGYyEEAVPLS molecular association, regulation Src(INDUCES) 9655255 1 2 4 Src Y529F Src mutant +SUPT5H SPT5 RNA-binding; Transcription, coactivator/corepressor O00267 6829 19q13.2 human T806-p 458819 TPHYGSQtPLHDGSR transcription, altered 16427012 2 12 68 required for c-fos induction and activation in vivo +FBXO31 FBXO31 Cell cycle regulation; UBIQUITIN LIGASE; Ubiquitin conjugating system; Ubiquitin ligase Q5XUX0 79791 16q24.2 human S33-p 485583 AETAAADsEPDTDPE protein degradation; ubiquitination 29343641 1 11 4 +MDC1 MDC1 Cell cycle regulation Q14676 9656 6p21.33 human T847-p 30996100 PERQTDVtGEEELTK molecular association, regulation cell cycle regulation TOP2A(DISRUPTS) 24349352 1 0 0 +Fxyd1 PLM Cell surface; Channel, misc.; Membrane protein, integral O08589 58971 1q21 rat S88-p 451425 RSSIRRLsTRRR___ activity, induced; molecular association, regulation; activity, inhibited ZDHHC5(INDUCES) 16434394; 17283221; 19339511; 21849407; 25422474 27 3 74 +Dnm1 DYN1 EC 3.6.5.5; Hydrolase; Microtubule-binding; Motility/polarity/chemotaxis; Motor; Vesicle P21575 140694 3p12 rat Y231-p 447605 LLPLRRGyIGVVNRS Dynamin_M molecular association, regulation; receptor internalization, altered; activity, inhibited; protein conformation 12011079; 9880482 2 2 0 Y231/597F mutant Inhibits B2-AR internalization, and inhibited the isoproterenol mediated activation of ERK2.; Tyrosine phosphorylation promotes DYN1 self assembly. +Rora RORA DNA-binding; Nuclear receptor P51448 19883 9 C|9 37.45 cM mouse S100-p 1212279800 CKGFFRRsQQSNATY zf-C4 molecular association, regulation transcription, induced HNF4 alpha(INDUCES); CaR(INDUCES) DNA(INDUCES) 31924695 4 1 0 +MAPT Tau iso8 ACETYLTRANSFERASE; Acetyltransferase; Cytoskeletal P10636-8 4137 17q21.31 human S356-p 449104 RVQSKIGsLDNITHV Tubulin-binding molecular association, regulation; intracellular localization; protein conformation cytoskeletal reorganization 10090741; 17725643; 21204788; 34936879; 36004506 35 24 0 +RUNX1 AML1 iso8 DNA-binding; Oncoprotein; Transcription factor Q01196-8 861 21q22.12 human S462-p 454402 AEGSHSNsPTNMAPS RunxI cell differentiation, induced 22531928 3 2 0 +IKZF1 Ikaros C2H2-type zinc finger protein; DNA-binding; Transcription factor Q13422 10320 7p12.2 human K241-sm 3609103 GTLYPVIkEETNHSE carcinogenesis, induced; cell growth, induced 27315244 2 0 0 +MAPT Tau iso8 ACETYLTRANSFERASE; Acetyltransferase; Cytoskeletal P10636-8 4137 17q21.31 human S285-p 487455 INKKLDLsNVQSKCG Tubulin-binding molecular association, regulation; protein conformation Tau(INDUCES) 36003083 2 3 0 +Akt2 Akt2 EC 2.7.11.1; KINASE; Kinase, protein; Oncoprotein; Protein kinase, AGC; Protein kinase, Ser/Thr (non-receptor) Q60823 11652 7 A3|7 15.94 cM mouse S474-p 448520 RTHFPQFsYSASIRE Pkinase_C transcription, induced 34704268 37 9 55 +CD79B Ig-beta Membrane protein, integral; Receptor, misc. P40259 974 17q23.3 human K219-ub 12312067 TLRTGEVkWSVGEHP intracellular localization 32127472 1 1 11 in cytoplasm +TUFT1 TUFT1 Q9NNX1 7286 1q21.3 human K79-sm 1883375202 DGHEEIIkVYLKGRS carcinogenesis, induced; cell motility, induced; cell growth, induced 36380570 1 0 0 +CERS3 LASS3 DNA-binding; EC 2.3.1.24; Membrane protein, integral; Membrane protein, multi-pass Q8IU89 204219 15q26.3 human S340-p 17545395 KSIQDVRsDDEDYEE enzymatic activity, induced 26887952 1 2 1 +H3F3C H3 DNA-binding P84229 427887 chicken S10-p 455676 TKQTARKsTGGKAPR Histone molecular association, regulation chromatin organization, altered; transcription, induced DNA(INDUCES) 17913747 241 15 1 +BAX BAX Apoptosis; Membrane protein, integral; Mitochondrial; Tumor suppressor Q07812 581 19q13.33 human S184-p 451017 VAGVLTAsLTIWKKM TM activity, induced; protein degradation; molecular association, regulation; intracellular localization; activity, inhibited carcinogenesis, induced; cell growth, induced; apoptosis, inhibited FBXL20(INDUCES) 15642728; 17911107; 34587475; 35250564; 37324940 9 0 0 +FTO FTO DEMETHYLASE; Demethylase; EC 1.14.11.- Q9C0B1 79068 16q12.2 human K216-ub 22244732 PQKMPYLkEEPYFGM FTO_NTD protein degradation carcinogenesis, induced 34218271 1 6 0 hypoxic tumor microenvironment promotes hypoxic tumor microenvironment promotes CRC metastasis; FTO exerts a tumor suppressive effect +Star STAR Carrier; Lipid-binding; Mitochondrial P70114 101844174 hamster S194-p 450442 RCAKRRGsTCVLAGI START enzymatic activity, induced 15336703 9 1 0 +PTH1R PTHR GPCR, family 2; Membrane protein, integral; Membrane protein, multi-pass; Receptor, GPCR Q03431 5745 3p21.31 human T503-p 58924701 YGPMVSHtSVTNVGP receptor internalization, induced; molecular association, regulation ARR3(INDUCES) 27623777 1 1 0 S503 AND T504 IN THE SECOND CLUSTER ARE RESPONSIBLE FOR 70% OF ARRESTIN3 RECRUITMENT +Ilk ILK EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, Ser/Thr (non-receptor); Protein kinase, TKL O55222 16202 7|7 E3 mouse S343-p 448495 SMADVKFsFQCPGRM PK_Tyr_Ser-Thr enzymatic activity, induced 25098415 4 0 1 +MAP2K6 MKK6 EC 2.7.12.2; KINASE; Kinase, protein; Protein kinase, STE; Protein kinase, dual-specificity (non-receptor) P52564 5608 17q24.3 human T211-p 448195 LVDSVAKtIDAGCKP Pkinase enzymatic activity, induced; phosphorylation transcription, induced; signaling pathway regulation 11460167; 8622669 4 2 2 +PRMT5 PRMT5 Cell cycle regulation; EC 2.1.1.125; METHYLTRANSFERASE; Methyltransferase; Methyltransferase, protein arginine; RNA processing O14744 10419 14q11.2 human S15-p 1868989002 GAGGSRVsSGRDLNC molecular association, regulation; enzymatic activity, induced carcinogenesis, induced; cell motility, induced; cell growth, induced; transcription, induced NFkB-p65(INDUCES) 32456215 1 0 0 Regulation of NFkB activation and methyltransferase activity +Npr2 ANPB EC 4.6.1.2; Guanylyl cyclase; KINASE; Kinase, protein; Lyase; Membrane protein, integral; Nucleotide Metabolism - purine; Protein kinase, RGC; Protein kinase, dual-specificity (receptor); Receptor, misc. P16067 116564 5q22 rat T516-p 450026 KGAGSRLtLSLRGSS activity, induced 9624142 2 1 0 +PPP1R1B DARPP-32 Motility/polarity/chemotaxis; Protein phosphatase, regulatory subunit Q9UD71 84152 17q12 human T34-p 448047 MIRRRRPtPAMLFRL DARPP-32 carcinogenesis, induced; cell motility, altered; cytoskeletal reorganization; signaling pathway regulation 19651774; 36966223 67 6 44 induces ERK signaling +EGR1 EGR1 C2H2-type zinc finger protein; DNA-binding; Transcription factor P18146 1958 5q31.2 human T148-p 11423703 PAPNSGNtLWPEPLF DUF3446 transcription, altered DNA(DISRUPTS) 8662759 1 0 0 +CHEK2 Chk2 EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, CAMK; Protein kinase, Ser/Thr (non-receptor); Tumor suppressor O96017 11200 22q12.1 human S516-p 448840 PQVLAQPsTSRKRPR enzymatic activity, induced cell cycle regulation; apoptosis, induced; transcription, induced 12805407; 12855706; 26391395; 30573684; 36007676 16 4 0 CRp53 +CYSLTR1 CYSLTR1 GPCR, family 1; Membrane protein, integral; Membrane protein, multi-pass; Receptor, GPCR Q9Y271 10800 Xq21.1 human S316-p 11146368 FRKHSLSsVTYVPRK receptor desensitization, induced transcription, induced 22230957 1 3 0 +Slco1a1 SLCO1A1 Membrane protein, integral; Transporter P46720 50572 4q44 rat S634-p 460719 QFPGDIDsSATDHTE molecular association, regulation; intracellular localization PDZK1(INDUCES) 21183661 1 1 0 plasma membrane distribution of SLCO1A1 requires interaction of its unphosphorylated form with PDZK1 +Kcnj1 ROMK iso2 Channel, potassium; Membrane protein, integral; Membrane protein, multi-pass P35560-2 rat S294-p 2461200 ATCQVRTsYVPEEVL IRK_C activity, induced 8621594 5 0 0 phosphorylation of at least two serines necessary for channel activity +USP37 USP37 DEUBIQUITINASE; EC 3.4.19.12; Protease; Ubiquitin conjugating system; Ubiquitin-specific protease Q86T82 57695 2q35 human S628-p 469345 MVNSCITsPSTPSKK UCH protein stabilization; ubiquitination cell cycle regulation 21596315 2 3 14 induces deubiquitination +RPA2 RFA2 DNA replication P15927 6118 1p35.3 human S12-p 1854602 GFESYGSsSYGGAGG molecular association, regulation; intracellular localization DNA repair, induced; cell growth, altered WRN(INDUCES) 17035231; 21107010 3 1 0 upon replication blockage, WRN and RPA functionally interact ; 7xAlanine mutant has defect in down regulating DNA synthesis following UV treatment. 7xAspartate mutant did not localize to S-phase foci. +FOXC2 FOXC2 Apoptosis; Cell development/differentiation; DNA-binding; Transcription factor Q99958 2303 16q24.1 human S240-p 3210585 PESALQGsPRSAAST molecular association, regulation transcription, altered DNA(INDUCES) 23878394 1 23 0 implicated in vascular remodeling in vivo +MLLT1 MLLT1 Oncoprotein; Transcription regulation Q03111 4298 19p13.3 human K469-ac 1881852003 KPPPPNSkVSGRRSP cell growth, induced 35108652 1 0 0 Sirt2 deletion AML cells showed significantly increased proliferation +Lmna lamin A/C Cytoskeletal P48679 60374 2q34 rat S301-p 480106 QSRIRIDsLSAQLSQ Filament protein degradation cell differentiation, induced 26045045 3 24 137 reduced nuclear size +Wnk4 WNK4 EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, Other; Protein kinase, Ser/Thr (non-receptor) Q80UE6 69847 11|11 D mouse K183-ub 40323313 EIGRGSFkTVYRGLD Pkinase protein degradation 23576762 1 1 0 regulates electrolyte homeostasis and involved in Pseudohypoaldosteronism type II (PHAII) pathogenesis +Pdc phosducin G protein regulator, misc. P20942 25343 13q21 rat S73-p 451205 ERMSRKMsIQEYELI Phosducin protein stabilization; molecular association, regulation; protein conformation G-gamma 2(DISRUPTS); 14-3-3 zeta(INDUCES); G-beta 1(DISRUPTS) 10360181; 11331285; 23199924; 25971962; 28402877 7 3 0 slows down the dephosphorylation of pS54 and pS73 +MYC Myc DNA-binding; Nucleolus; Oncoprotein; Transcription factor P01106 4609 8q24.21 human K172-ac 458890 ASYQAARkDSGSPNP Myc_N molecular association, regulation ZBTB17(INDUCES) 16126174 3 2 0 induces association with ZBTB17 on specific target promoters +G6PC1 G6PC1 Carbohydrate Metabolism - galactose; Carbohydrate Metabolism - glycolysis and gluconeogenesis; Carbohydrate Metabolism - starch and sucrose; EC 3.1.3.9; Endoplasmic reticulum; Membrane protein, integral; Membrane protein, multi-pass; Phosphatase (non-protein); Transporter; Transporter, SLC family P35575 2538 17q21.31 human H119-p 27988900 GPGSPSGhAMGTAGV PAP2; TM enzymatic activity, induced 7744838 1 0 0 Likely that H119 is the phosphate acceptor in G6PC. +GATA6 GATA6 iso2 Motility/polarity/chemotaxis; Transcription factor Q92908-2 2627 18q11.2 human S290-p 18009944 KPQKRVPsSRRLGLS protein stabilization; molecular association, regulation cell growth, inhibited; transcription, induced DNA(INDUCES) 25969542 1 2 0 +Etv4 ETV4 DNA-binding P28322 18612 11 D|11 65.48 cM mouse K227-sm 3144819 PYPQQNFkQEYHDPL ETS_PEA3_N protein degradation; ubiquitination transcription, induced; transcription, inhibited 18447755; 19307308 4 1 0 +Camk2b CAMK2B EC 2.7.11.17; KINASE; Kinase, protein; Protein kinase, CAMK; Protein kinase, Ser/Thr (non-receptor) P28652 12323 11 A1|11 3.89 cM mouse S26-p 455245 DIGKGAFsVVRRCVK Pkinase enzymatic activity, inhibited 36194579 1 4 0 +CAV1 caveolin-1 Adaptor/scaffold; Motility/polarity/chemotaxis; Nuclear receptor co-regulator Q03135 857 7q31.2 human K57-ub 21170998 DLVNRDPkHLNDDVV Caveolin molecular association, regulation; intracellular localization UBXN6(INDUCES); VCP(INDUCES) 23335559 1 5 0 CAV1 ubiquitylation and binding to the VCP-UBXD1 complex and sorting into lysosomes +ARHGAP25 ARHGAP25 GAP; GAP, Rac/Rho P42331 9938 2p13.3 human S362-p 12738768 KSKDIPLsPPAQKND activity, inhibited endocytosis, induced 36190314 1 17 0 +Lima1 eplin Actin-binding; Cytoskeletal; Motility/polarity/chemotaxis Q9ERG0 65970 15 F1|15 56.13 cM mouse S602-p 459750 FRTSSIKsPKASSPS molecular association, regulation; intracellular localization cell motility, induced; cytoskeletal reorganization ACTB(DISRUPTS) 17875928 3 29 16 destabilization of stress fibres, membrane ruffle formation +TAB1 TAB1 Activator; Motility/polarity/chemotaxis Q15750 10454 22q13.1 human S457-p 22869800 TQSSSSSsDGGLFRS intracellular localization; phosphorylation; enzymatic activity, induced transcription, inhibited 22216226 1 0 0 TAB1 induce p38 MAPK phosphorylation and mRNA destabilization, induces p38 MAPK activation. TAB1 and p38MAPK mutually control eachother's phosphorylation status, activity and intracellular localization. +TARDBP TDP-43 RNA-binding Q13148 23435 1p36.22 human S375-p 6855909 GSGNNSYsGSNSGAA molecular association, regulation cell cycle regulation; cell growth, induced; apoptosis, inhibited; transcription, altered TDP-43(DISRUPTS) 35835219 2 0 0 +SFRP4 SFRP4 Secreted; Secreted, signal peptide Q6FHJ7 6424 7p14.1 human T186-p 50799489 KCKKVKPtLATYLSK molecular association, regulation carcinogenesis, induced; transcription, induced; signaling pathway regulation CTNNB1(INDUCES) 31390565 1 1 0 induces B-catenin transcriptional activity and CD133 expression, regulates Wnt/B-catenin signaling pathway +Eps8 EPS8 Adaptor/scaffold Q08509 13860 6 G1|6 66.78 cM mouse S624-p 7101206 ADTPSAPsPPPTPAP intracellular localization cytoskeletal reorganization 19564905 1 11 0 +Dpysl2 CRMP-2 Microtubule-binding; Motility/polarity/chemotaxis O08553 12934 14 D1|14 34.6 cM mouse T514-p 454386 SVTPKTVtPASSAKT molecular association, regulation neural plasticity; cell motility, induced; cytoskeletal reorganization; cell growth, altered DRP1(DISRUPTS); RHOT2(DISRUPTS) 20961402; 25073924; 34685760; 36293516 33 36 35 +BCR Bcr EC 2.7.11.1; GAP; GAP, Rac/Rho; GEF, Rac/Rho; KINASE; Kinase, protein; Oncoprotein; Protein kinase, Ser/Thr (non-receptor); Protein kinase, atypical P11274 613 22q11.23 human Y328-p 447795 FEDCGGGyTPDCSSN enzymatic activity, induced 9467953 2 0 0 +TPPP TPPP Cytoskeletal O94811 11076 5p15.33 human S159-p 487537 SGVTKAIsSPTVSRL p25-alpha acetylation; phosphorylation transcription, induced 23727580 2 5 1 decreases B-Catennin phosphorylation and acetylation and induces its expression +Gorasp1 GRASP65 Vesicle O35254 56082 8q32 rat T224-p 4768154 SPGTPAKtPQPNAFP intracellular localization cell cycle regulation 23259055 1 0 0 Regulation of mitotic golgi disassembly and reassembly; inactivation of T220/T224, and eventually S277partial dephosphorylation +Pld1 PLD1 EC 3.1.4.4; Lipid Metabolism - ether lipid; Lipid Metabolism - glycerophospholipid; Motility/polarity/chemotaxis; Phospholipase P70496 25096 2q24 rat T147-p 448573 PIPTKRHtFRRQNVK PX intracellular localization; enzymatic activity, induced exocytosis, altered 12429840; 18550821 5 0 0 Phosphorylation occurs in caveolin-enriched membrane fraction and is localized to the plasma membrane in cells.; T147-p is required for PLD1 mediated PA production and exocytosis. +AGAP2 CENTG1 iso2 GAP; GAP, ARF; Motility/polarity/chemotaxis; Tumor suppressor Q99490-2 116986 12q14.1 human S279-p 478561 YSSSLPSsPNVGHRE molecular association, regulation; enzymatic activity, induced cell motility, altered Akt1(DISRUPTS) 18487454 1 2 20 +WT1 WT1 iso7 C2H2-type zinc finger protein; DNA-binding; Nucleolus; Transcription factor; Tumor suppressor P19544-7 7490 11p13 human S63-p 1871128700 ERLQGRRsRGASGSE protein degradation; molecular association, regulation; ubiquitination carcinogenesis, inhibited; cell growth, inhibited; transcription, inhibited FBXW8(INDUCES) 33184107 1 1 0 +ITGB1 ITGB1 Cell adhesion; Cell surface; Membrane protein, integral; Motility/polarity/chemotaxis; Receptor, misc. P05556 3688 10p11.22 human Y795-p 447711 TTVVNPKyEGK____ Integrin_b_cyt molecular association, regulation; intracellular localization kindlin-2(DISRUPTS); tensin 1 iso1(INDUCES) 17473008; 20702409 7 13 211 +DNM1L DRP1 Apoptosis; EC 3.6.5.5; Endoplasmic reticulum; Hydrolase; Microtubule-binding; Mitochondrial; Motor O00429 10059 12p11.21 human K532-sm 9859919 PSAVSRDkSSKVPSA activity, induced; intracellular localization 19638400 1 0 0 sumoylation is linked to its GTPase activity cycle, and influenced by DRP1 localization +Dennd3 DENND3 GEF; GEF, Rab A2RT67 105841 15|15 D3 mouse Y940-p 15568930 HAASKLAyFDNMKKK molecular association, regulation; protein conformation DENND3(DISRUPTS) 28249939 1 0 1 +RUNX1 AML1 DNA-binding; Oncoprotein; Transcription factor Q01196 861 21q22.12 human K24-ac 459071 STALSPGkMSEALPL molecular association, regulation cell growth, induced; transcription, induced DNA(INDUCES) 14752096 1 4 15 transformation increased +PINK1 PINK1 EC 2.7.11.1; KINASE; Kinase, protein; Membrane protein, integral; Mitochondrial; Protein kinase, Other; Protein kinase, Ser/Thr (non-receptor) Q9BXM7 65018 1p36.12 human S228-p 25792200 MWNISAGsSSEAILN ubiquitination; intracellular localization; phosphorylation; enzymatic activity, induced 22910362; 23754282; 25527497 8 2 0 T313A and S402A mutants interfere with PINK1 phosphorylation; regulate substrate phosphorylation, Parkin and Ubiquitin; promotes mitochondrial localization of parkin; induce Ubiquitin-oxyester formation +FOXG1 FOXG1 DNA-binding; Nuclear receptor co-regulator; Transcription factor P55316 2290 14q12 human T279-p 482881 KLRRRSTtSRAKLAF intracellular localization 17435750 3 0 0 +Frs2 FRS2 Adaptor/scaffold Q8C180 327826 10|10 D2 mouse Y392-p 449785 NLDPMHNyVNTENVT molecular association, regulation GRB2(INDUCES) 9182757 3 2 26 +WWC1 KIBRA Adaptor/scaffold Q8IX03 23286 5q34 human T1006-p 54400801 RTWHSQLtQEISVLK DNA repair, induced; cell growth, induced 26929199 1 0 0 required for optimal DNA double-strand break repair in cancer cells +COX2 COX2 EC 1.9.3.1; Energy Metabolism - oxidative phosphorylation; Membrane protein, integral; Membrane protein, multi-pass; Mitochondrial; Oxidoreductase P68530 3283880 cow S126-p 25265503 DSYMIPTsELKPGEL COX2 signaling pathway regulation 21771582 0 2 0 regualtion of electron transport chain +KLHL3 KLHL3 Actin-binding; Cytoskeletal Q9UH77 26249 5q31.2 human S433-p 36440206 PMNTRRSsVGVGVVE Kelch_1 protein stabilization; molecular association, regulation; ubiquitination; protein conformation signaling pathway regulation WNK4(DISRUPTS) 25313067; 26435498; 27727489; 27942049; 30718414 6 2 0 +H3c1 H3 DNA-binding P68433 360198 13|13 A3.1 mouse K36-m3 1458608 APATGGVkKPHRYRP Histone cell differentiation, induced; chromatin organization, altered; transcription, induced; transcription, inhibited 19434510; 23428873; 26370508; 33743353 65 11 4 Setd2 knockout embryos suffer from anemia, Setd2 de?ciency impairs terminal differentiation, Increased nucleated erythrocytes; repressive effect on noncoding RNA (ncRNA) Xist promoter +EIF4ENIF1 4E-T Karyopherin; Nuclear import; Translation Q9NRA8 56478 22q12.2 human S587-p 454357 YLRPRIPsPIGFTPG EIF4E-T molecular association, regulation 4E-T(INDUCES) 22966201 1 30 113 required for processing bodies (PBs or P bodies) assembly +FERMT3 kindlin-3 Cell adhesion Q86UX7 83706 11q13.1 human T482-p 15406839 AFLSLQRtGSGGPGN FERM_M activity, induced cell motility, induced; cell adhesion, induced 25609252 1 1 0 integrin activation, adhesion and spreading +NPFFR2 NPFFR2 GPCR, family 1; Membrane protein, integral; Membrane protein, multi-pass; Receptor, GPCR Q9Y5X5 10886 4q13.3 human T516-p 36533408 VMEELKEtTNSSEI_ receptor desensitization, induced 25326382 1 1 0 +HJURP HJURP Histone-binding; Nucleolus Q8NCD3 55355 2q37.1 human S448-p 3206595 LHREYCLsPRNQPRR HJURP_C molecular association, regulation; intracellular localization cell cycle regulation OIP5(DISRUPTS) 24519934 2 9 6 Mis18 binds with HJURP and specifies the centromere localization +Lrp4 LRP4 Cell surface; Membrane protein, integral; Receptor, misc. Q9QYP1 83469 3q24 rat S1900-p 465667 WKHERKLsSESQV__ molecular association, regulation DLG1(DISRUPTS); PSD-95(DISRUPTS) 16819975 1 2 4 +PAK6 PAK6 EC 2.7.11.1; KINASE; Kinase, protein; Nuclear receptor co-regulator; Protein kinase, STE; Protein kinase, Ser/Thr (non-receptor) Q9NQU5 56924 15q15.1 human S165-p 454427 MPWPEPQsPRVLPNG enzymatic activity, induced 15550393 1 2 0 +MRE11 MRE11A Cell cycle regulation; DNA repair, damage; DNA-binding; Deoxyribonuclease P49959 4361 11q21 human S264-p 486366 EQQLFYIsQPGSSVV molecular association, regulation DNA(DISRUPTS) 19709933 2 0 0 +TOB2 TOB2 Q14106 10766 22q13.2 human S155-p 22999101 SSLSNSPsPSFGQSP cell growth, inhibited 22252318 1 0 0 promote mRNA deadenylaion and decay and the ability to suppress proliferation +PSEN1 PSEN1 Cell surface; EC 3.4.23.-; Membrane protein, integral; Membrane protein, multi-pass; Mitochondrial; Protease P49768 5663 14q24.2 human S313-p 62906105 QRRVSKNsKYNAEST Presenilin protein conformation 28132667 1 1 0 PS1 pathogenic conformational shift +Pfkfb1 PFKFB1 Carbohydrate Metabolism - fructose and mannose; EC 2.7.1.105; EC 3.1.3.46; Kinase, other; Motility/polarity/chemotaxis; Phosphatase (non-protein) P07953 24638 Xq13 rat S33-p 456206 VLQRRRGsSIPQFTN 6PF2K molecular association, regulation; intracellular localization; enzymatic activity, inhibited; enzymatic activity, induced PFKFB1(INDUCES) DNA(DISRUPTS) 10749675; 15983194; 22668829; 7619045 6 3 0 decreases the PFK activity, increases the FBPase activity +SYT6 SYT6 Membrane protein, integral; Vesicle Q5T7P8 148281 1p13.2 human T418-p 456499 RLKKKKTtIKKNTLN C2 activity, induced 16111671 1 0 0 +Ceacam1 CEACAM1 Cell adhesion; Immunoglobulin superfamily; Membrane protein, integral; Motility/polarity/chemotaxis P16573 81613 1q21 rat S449-p 22636602 ALAYFLYsRKTGGGS molecular association, regulation Calmodulin(DISRUPTS) 9541029 1 0 0 +MARS1 MARS Aminoacyl-tRNA synthetase; EC 6.1.1.10; Ligase; Other Amino Acids Metabolism - selenoamino acid; Translation; Translation regulation P56192 4141 12q13.3 human S662-p 22496701 NRAGMFVsKFFGGYV molecular association, regulation; enzymatic activity, inhibited; protein conformation translation, inhibited EEF1E1(DISRUPTS) 22106287 1 1 0 +Clip1 Restin Cytoskeletal Q9JK25 65201 12q16 rat S313-p 4769839 LKRSPSAsSLSSMSS molecular association, regulation TUBA1C(DISRUPTS) 20519438 1 3 0 +Adam17 TACE EC 3.4.24.86; Membrane protein, integral; Motility/polarity/chemotaxis; Protease Q9Z1K9 57027 6q16 rat Y702-p 28706300 DKKLDKQyESLSLFH activity, induced; phosphorylation; enzymatic activity, induced 23868980; 25371038 3 0 0 p38 is phosphorylated and activated due to TACE phosphorylation.; myogenesis activation, p38MAPK activation (phosphorylation), TNF-a release +FOXO3 FOXO3A Autophagy; DNA-binding; Oncoprotein; Transcription factor O43524 2309 6q21 human K245-ac 50771300 PDGGKSGkAPRRRAV Forkhead activity, induced; intracellular localization; phosphorylation 26376801 1 0 0 K245 and K242 acetylation is associated with JNK activation, nuclear localization, and S7 phosphorylation +PPP2CA PPP2CA EC 3.1.3.16; Motility/polarity/chemotaxis; PHOSPHATASE; Protein phosphatase, Ser/Thr (non-receptor) P67775 5515 5q31.1 human L309-me 3627520 RRTPDYFl_______ molecular association, regulation; enzymatic activity, induced; phosphorylation carcinogenesis, inhibited; cell growth, inhibited; apoptosis, induced; signaling pathway regulation 24253382; 32315619; 8206937 10 0 0 inhibits ERK and AKT phosphorylation and signaling +PHLPP1 PHLPP EC 3.1.3.16; PHOSPHATASE; Protein phosphatase, Ser/Thr (non-receptor); Tumor suppressor O60346 23239 18q21.33 human S425-p 23131538 KAPRAIDsPGGAVRE cell cycle regulation 33397691 1 9 1 +TP53 p53 Activator; DNA-binding; Motility/polarity/chemotaxis; Nuclear receptor co-regulator; Transcription factor; Tumor suppressor P04637 7157 17p13.1 human K382-m1 4061501 QSTSRHKkLMFKTEG activity, inhibited cell cycle regulation; carcinogenesis, inhibited; apoptosis, inhibited; transcription, inhibited 17707234; 27535933 2 1 0 +Ctnnd2 CTNND2 Actin-binding; Motility/polarity/chemotaxis NP_001258431 114028 2q22 rat S444-p 480954 RTSTAPSsPGVDSVP cytoskeletal reorganization 19054758 1 9 1 mutation of site to alanine increases dendrite branching +Brsk2 BRSK2 EC 2.7.11.1; EC 2.7.11.26; KINASE; Kinase, protein; Protein kinase, CAMK; Protein kinase, Ser/Thr (non-receptor) Q69Z98 75770 7|7 F5 mouse T510-p 3572413 PEEMSNLtPESSPEL protein stabilization; enzymatic activity, inhibited; phosphorylation 23790753 1 11 10 inhibits axon branching (activated in BRSK2 18A mutant) +PSMA7 PSMA7 EC 3.4.25.1; Protease; Proteasome complex O14818 5688 20q13.33 human Y153-p 456317 QTDPSGTyHAWKANA Proteasome enzymatic activity, inhibited cell cycle regulation 16678104 2 5 65 +XRCC5 Ku80 DNA-binding; EC 3.6.1.-; EC 3.6.4.-; Helicase; Nuclear receptor co-regulator; Nucleolus; RNA-binding P13010 7520 2q35 human K469-ub 12398997 SLAKKDEkTDTLEDL molecular association, regulation DNA repair, induced DNA(DISRUPTS) 27895153 1 2 4 +Grik2 GluR6 Channel, calcium; Channel, ligand-gated; Membrane protein, integral; Membrane protein, multi-pass P42260 54257 20q13 rat S846-p 11496000 VGEFLYKsKKNAQLE receptor recycling, inhibited; molecular association, regulation exocytosis, inhibited 14-3-3 theta(INDUCES) 23861400; 28636947 5 0 0 recycled more ef?ciently to the cell surface +PIK3R2 PIK3R2 Kinase, lipid; Motility/polarity/chemotaxis O00459 5296 19p13.11 human Y655-p 25749689 ESSQRGCyACSVVVD SH2 protein stabilization; molecular association, regulation carcinogenesis, inhibited; autophagy, induced; signaling pathway regulation FBXL2(DISRUPTS) 23604317; 28915558 2 0 1 +Sirt1 SIRT1 Apoptosis; DEACETYLASE; Deacetylase; EC 3.5.1.-; Nuclear receptor co-regulator Q923E4 93759 10|10 B4 mouse S154-p 6006902 NGFHSCEsDDDDRTS enzymatic activity, induced apoptosis, inhibited; transcription, induced 19680552; 27470296 2 5 0 ERb expression, reduced S154 phosphorylation in aging mouse leads to reduced ERB expression ; deacetylates p53 K382 and NFkB-p65 +RANGAP1 RANGAP1 GAP; GAP, Ras P46060 5905 22q13.2 human K524-sm 2251700 LVHMGLLkSEDKVKA RanGAP1_C sumoylation; intracellular localization; protein conformation 15355965; 34110283 11 12 0 change in resonances from residues 519 to 534 ; WT RANGAP1 rescues nuclear import of NF-ATc1, NF-kB, AP-1 in RanGAP1 (KD), required in various nuclear transport pathways +Rit1 RIT1 G protein; G protein, monomeric; G protein, monomeric, Ras P70426 19769 3|3 F1 mouse K187-ub 964541202 REIRKKEkELVLAME protein degradation; ubiquitination 30872527 1 2 0 ubiquitination occured only when TUBEs and LZTR1 were coexpressed, when RIT1 oncogenic mutations are present ubiquitination was decreased +IKZF1 Ikaros C2H2-type zinc finger protein; DNA-binding; Transcription factor Q13422 10320 7p12.2 human K429-sm 56819000 ARNGLSLkEEHRAYD carcinogenesis, induced; cell growth, induced 27315244 1 0 0 +RSAD2 RSAD2 Q8WXG1 91543 2p25.2 human K206-ub 12402572 NHVENLQkLRRWCRD Radical_SAM protein degradation 31812350 1 1 1 +PIK3C3 PIK3C3 Autophagy; Carbohydrate Metabolism - inositol phosphate; EC 2.7.1.137; Kinase, lipid; Motility/polarity/chemotaxis Q8NEB9 5289 18q12.3 human K840-sm 31077507 LEPDKTVkKVQDKFR enzymatic activity, induced autophagy, induced 23569248 2 0 0 +DYRK1A DYRK1A EC 2.7.12.2; KINASE; Kinase, protein; Protein kinase, CMGC; Protein kinase, dual-specificity (non-receptor) Q13627 1859 21q22.13 human Y147-p 463250 YDDDNYDyIVKNGEK intracellular localization cell cycle regulation; cell differentiation, altered 21878370 1 2 18 +NPHS1 NPHS1 Cell adhesion; Immunoglobulin superfamily; Membrane protein, integral O60500 4868 19q13.12 human Y1217-p 469566 YQDPRGIyDQVAGDL protein degradation; intracellular localization endocytosis, induced; exocytosis, induced; cell adhesion, induced; cytoskeletal reorganization; translation, inhibited 19882202; 22718751; 25404734 10 0 0 +Rb1 Rb Nuclear receptor co-regulator; Oncoprotein; Transcription, coactivator/corepressor; Tumor suppressor P13405 19645 14 38.73 cM|14 D3 mouse S773-p 447978 STRPPTLsPIPHIPR Rb_C molecular association, regulation; phosphorylation cell cycle regulation; cell growth, induced; DNA repair, inhibited E2F1(DISRUPTS) 10207050; 35023164 98 17 128 +Myc Myc DNA-binding; Nucleolus; Oncoprotein; Transcription factor P01108 17869 15 D1|15 26.19 cM mouse S388-p 450961 RRNELKRsFFALRDQ HLH molecular association, regulation; activity, inhibited cell cycle regulation; apoptosis, inhibited; transcription, altered; transcription, inhibited; cell growth, altered MAX(DISRUPTS) 14749374; 20043278 8 0 0 mutation of this site enhances epidermal differentiation +Nr5a1 STF-1 Nuclear receptor; Transcription, coactivator/corepressor P33242 26423 2 B|2 24.42 cM mouse S203-p 447603 EYPEPYAsPPQQPGP activity, induced; molecular association, regulation; protein conformation transcription, induced; transcription, altered SMRT(INDUCES); GRIP1(INDUCES) 10230405; 12242296; 12920232; 19015234; 24232453 11 0 0 +CRK CRK Adaptor/scaffold; Motility/polarity/chemotaxis; Oncoprotein P46108 1398 17p13.3 human Y251-p 456549 QKRVPNAyDKTALAL SH3_2 molecular association, regulation; enzymatic activity, induced cell motility, induced; cell adhesion, inhibited Arg(INDUCES); STAP1(INDUCES); Abl(INDUCES); Abi-1(INDUCES); SHIP-2(INDUCES); SHC2(INDUCES) 21602891; 25381819; 26473374 3 11 308 +ZNF746 PARIS C2H2-type zinc finger protein; Transcription regulation Q6NUN9 155061 7q36.1 human Y137-p 13831906 ETLVSLDyAISKPEV activity, induced; molecular association, regulation; acetylation; intracellular localization; phosphorylation; enzymatic activity, induced apoptosis, induced; transcription, inhibited; signaling pathway regulation TIF1B(INDUCES) 34581802 1 1 0 induces p53 phosphorylation and activation and c-Abl activation, inhibits histone acetylation, regulates MDM4-p53/PGC-1-NRF1 pathway +CLASP2 CLASP2 Cytoskeletal; Motility/polarity/chemotaxis O75122 23122 3p22.3 human S533-p 22349885 QGCSREAsRESSRDT molecular association, regulation; intracellular localization cytoskeletal reorganization EB1(DISRUPTS); IQGAP1(DISRUPTS) 19638411 1 4 0 inhibits binding with microtubules +NR4A1 Nur77 Apoptosis; DNA-binding; Nuclear receptor P22736 3164 12q13.13 human K536-ub 1869841400 NRIASCLkEHVAAVA Hormone_recep protein degradation 33087562 2 0 0 +Sik1 SIK EC 2.7.11.1; KINASE; Kinase, protein; Motility/polarity/chemotaxis; Protein kinase, CAMK; Protein kinase, Ser/Thr (non-receptor); Tumor suppressor Q9R1U5 59329 20p12 rat T322-p 990311 LGIDRQRtVESLQNS enzymatic activity, induced 17939993 1 0 0 +KCNJ13 KCNJ13 Channel, potassium; Membrane protein, integral; Membrane protein, multi-pass O60928 3769 2q37.1 human S201-p 6039502 TRPSPLTsVRVSAVL IRK_C activity, inhibited 18976636 1 0 0 +Gja1 GJA1 Channel, misc.; Membrane protein, integral; Membrane protein, multi-pass; Motility/polarity/chemotaxis P08050 24392 20q11 rat S369-p 459208 RPSSRASsRASSRPR activity, induced; intracellular localization; protein conformation 12417300; 12697837; 16709897 15 8 2 BIM treatment in Rin43 cells and NRK-CT cells reduced multiple open states. In ischemic hearts Cx43 was uniformly distributed around each myocyte. ; altered intracellular localization during cell cycle; gap junction/intercellular communication +SHC1 SHC1 Adaptor/scaffold; Apoptosis; Mitochondrial; Motility/polarity/chemotaxis P29353 6464 1q21.3 human S139-p 448791 EEWTRHGsFVNKPTR apoptosis, induced 27624939 4 35 16 +AURKA AurA EC 2.7.11.1; KINASE; Kinase, protein; Oncoprotein; Protein kinase, Other; Protein kinase, Ser/Thr (non-receptor) A5GFW1 574063 pig S283-p 3339003 GWSVHAPsSRRTTLC Pkinase cell cycle regulation 18614302 1 0 0 +PRKCD PKCD EC 2.7.11.13; KINASE; Kinase, protein; Nuclear receptor co-regulator; Protein kinase, AGC; Protein kinase, Ser/Thr (non-receptor); Protein kinase, tyrosine (non-receptor); Tumor suppressor Q05655 5580 3p21.1 human Y64-p 447581 STFDAHIyEGRVIQI activity, inhibited; phosphorylation apoptosis, altered; apoptosis, induced 11927579; 18434324 7 3 31 ERK phosphorylation/activation +Ppp1r2 PPP1R2 Inhibitor; Motility/polarity/chemotaxis; Protein phosphatase, regulatory subunit P50411 192361 11q22 rat S44-p 2231000 EEELSKKsQKWDEMN enzymatic activity, induced neural plasticity 23825423 2 0 0 +Rbl2 Rb-like 2 Transcription, coactivator/corepressor; Tumor suppressor Q64700 19651 8 C4|8 44.25 cM mouse K130-ac 15207811 IEFFNKMkKWEDMAN DUF3452 phosphorylation 23029429 2 1 0 enhances phosphorylation of Rb-like2 +Th TH Amino Acid Metabolism - tyrosine; EC 1.14.16.2; Endoplasmic reticulum; Mitochondrial; Oxidoreductase; Vesicle P04177 25085 1q41 rat S40-p 448545 RFIGRRQsLIEDARK TOH_N protein stabilization; molecular association, regulation; protein conformation; enzymatic activity, induced 10820208; 11502746; 12124439; 12692140; 1347949; 15228599; 15639226; 17507557; 21302933; 33078695; 9751201 62 11 11 +Ptpn1 PTP1B EC 3.1.3.48; Motility/polarity/chemotaxis; PHOSPHATASE; Phosphatase; Protein phosphatase, tyrosine (non-receptor) P35821 19246 2|2 H3 mouse S205-p 36133122 VRESGSLsLEHGPIV Y_phosphatase phosphorylation; enzymatic activity, induced carcinogenesis, induced; apoptosis, inhibited 37000627 1 2 0 dephosphorylates CD3Z +MVB12A FAM125A Adaptor/scaffold Q96EY5 93343 19p13.11 human S207-p 13211303 NDSIYEAsSLYGISA DUF2464 protein processing 18005716 1 2 10 inhibition of HIV-1 release and infectivity +BRSK1 BRSK1 EC 2.7.11.1; EC 2.7.11.26; KINASE; Kinase, protein; Protein kinase, CAMK; Protein kinase, Ser/Thr (non-receptor) Q8TDC3 84446 19q13.42 human T189-p 456027 VGDSLLEtSCGSPHY Pkinase cytoskeletal reorganization 34936879 8 1 0 +Gsc GSC DNA-binding; Transcription factor Q02591 14836 12 E|12 54.32 cM mouse K196-sm 2887201 TREQLARkVHLREEK Homeodomain transcription, inhibited 18336814 1 0 0 SUMO modification inhibition is promoter specific +GCSAM GCET2 Unknown function Q8N6F7 257144 3q13.2 human Y86-p 449473 TYSEELCyTLINHRV HGAL activity, induced signaling pathway regulation 31362927 1 1 85 regulates B cell receptor signaling +LGALS3 galectin-3 Cell surface; Extracellular matrix; Motility/polarity/chemotaxis P17931 3958 14q22.3 human Y118-p 13213700 AGPLIVPyNLPLPGG Gal-bind_lectin protein stabilization; protein conformation carcinogenesis, induced; apoptosis, altered 20150913; 24269589 3 1 0 +Dhx33 DHX33 EC 3.6.4.13; Helicase; Nucleolus Q80VY9 216877 11|11 B4 mouse K94-ub 21172930 IGETGSGkTTQIPQY DEAD protein degradation 36403931 1 2 0 +PARL PSARL Apoptosis; EC 3.4.21.105; Membrane protein, integral; Membrane protein, multi-pass; Mitochondrial; Protease Q9H300 55486 3q27.1 human S70-p 471332 RRSDPGTsGEAYKRS protein processing 17116872 1 1 0 involved in mitochondrial fragmentation +Irf2 IRF2 DNA-binding; Transcription factor P23906 16363 8|8 B1.1 mouse Y109-p 478391 GNNAFRVyRMLPLSE IRF molecular association, regulation transcription, induced IRF8(INDUCES); PU.1(INDUCES); IRF2(INDUCES) 17200120 1 0 0 +VHL VHL Tumor suppressor; UBIQUITIN LIGASE; Ubiquitin ligase P40337 7428 3p25.3 human S43-p 15573202 EESGPEEsGPEELGA protein degradation transcription, altered 20637892; 26973240 2 0 0 VHL clevaage and subsequent degradation; regulates p53 activity and degradation of HIF1A +Rara RARA DNA-binding; Nuclear receptor; Oncoprotein; Transcription factor P11416 19401 11 D|11 62.76 cM mouse S369-p 451381 YVRKRRPsRPHMFPK Hormone_recep activity, induced; protein degradation 19029980; 7476969 8 0 0 Mutation of S369 to alanine slightly decreased both DNA binding and the ability of PKA to enhance RA-induced transcriptional activation through RAR-alpha. +NEUROG3 neurogenin 3 Cell development/differentiation; DNA-binding; Transcription factor Q9Y4Z2 50674 10q22.1 human S174-p 64303300 GDWGSLYsPVSQAGS transcription, inhibited 28441528 1 0 0 +MAP4 MAP4 Cytoskeletal; Motility/polarity/chemotaxis P27816 4134 3p21.31 human T927-p 10422252 LSRLATNtSAPDLKN Tubulin-binding protein degradation; molecular association, regulation cell cycle regulation; cytoskeletal reorganization; signaling pathway regulation E7(DISRUPTS) 31253867 1 3 8 +Pdzd11 PDZD11 Adaptor/scaffold Q9CZG9 72621 X|X C3 mouse Y7-p 462550 _MDNRIPyDDYPVVF molecular association, regulation SERCA2(INDUCES); DECR1(INDUCES); S100A4(INDUCES); MYH3(INDUCES); MRLC2(INDUCES) 18268350 0 4 40 +MYOD1 MyoD DNA-binding; RNA splicing; Transcription factor P15172 4654 11p15.1 human K102-ac 458969 LWACKACkRKTTNAD Basic molecular association, regulation; protein conformation cell differentiation, induced; transcription, induced p300(INDUCES) DNA(INDUCES) 10619020; 18222173 3 1 1 +Grik2 GluR6 Channel, calcium; Channel, ligand-gated; Membrane protein, integral; Membrane protein, multi-pass P42260 54257 20q13 rat S715-p 451343 FMSSRRQsVLVKSNE Lig_chan activity, induced 8094892 1 0 0 PKA-mediated phosphorylation increases the potentiation of the glutamate response. +CDC34 CDC34 EC 6.3.2.19; Ligase; UBIQUITIN LIGASE; Ubiquitin conjugating system; Ubiquitin ligase P49427 997 19p13.3 human S231-p 448654 FGDDEDDsGTEES__ intracellular localization 11546811 2 0 0 +Foxp3 FOXP3 C2H2-type zinc finger protein; Cell cycle regulation; DNA-binding; Transcription factor Q99JB6 20371 X A1.1|X 3.41 cM mouse K262-ac 25614400 MQAHLAGkMALAKAP protein stabilization; ubiquitination; intracellular localization cell differentiation, induced; transcription, altered 22312127; 30886050 3 1 0 inhibits ubiquitination; suppress production of the proinflammatory cytokines IFN-c and IL-17 by T cells, Treg gene expression and function +CYTH1 cytohesin 1 GEF; GEF, ARF; Motility/polarity/chemotaxis Q15438 9267 17q25.3 human S394-p 1319401 ARKKKVSsTKRH___ activity, induced 18042453 1 0 0 increase in exchange activity, GRP1 autoinhibition reversed +TWIST1 TWIST1 Cell development/differentiation; DNA-binding; Inhibitor; Transcription regulation Q15672 7291 7p21.1 human S18-p 18899301 SPADDSLsNSEEEPD protein stabilization carcinogenesis, altered; cell motility, altered 21559372 1 0 0 +LPAR1 LPAR1 GPCR, family 1; Membrane protein, integral; Membrane protein, multi-pass; Receptor, GPCR Q92633 1902 9q31.3 human T236-p 2764301 FGYVRQRtMRMSRHS 7tm_1 activity, inhibited 18501205 1 0 0 +EGFR EGFR EC 2.7.10.1; KINASE; Kinase, protein; Membrane protein, integral; Oncoprotein; Protein kinase, TK; Protein kinase, tyrosine (receptor) P00533 1956 7p11.2 human K913-ub 1065317 ELMTFGSkPYDGIPA PK_Tyr_Ser-Thr protein degradation 17940017 1 1 0 +GGA1 GGA1 Adaptor/scaffold; Vesicle Q9UJY5 26088 22q13.1 human S268-p 1245522 PTLFRLAsDTEDNDE GAT intracellular localization 14690499 1 5 38 +WDR62 WDR62 Adaptor/scaffold O43379 284403 19q13.12 human S897-p 291887111 KPESLENsILDSLEP cell cycle regulation; cytoskeletal reorganization 28973348 1 0 0 assembles astral microtubules to control spindle orientation +TTK TTK Cancer Testis Antigen (CTA); EC 2.7.12.1; KINASE; Kinase, protein; Protein kinase, Other; Protein kinase, dual-specificity (non-receptor) P33981 7272 6q14.1 human T564-p 4145511 LEEADNQtLDSYRNE Pkinase intracellular localization; enzymatic activity, induced 26119734 2 0 0 regulates spindle assembly checkpoint and recruitment of SAC proteins +Cyba CYBA EC 1.-.-.-; Membrane protein, integral; Oxidoreductase Q61462 13057 8|8 E1 mouse T147-p 7103047 ERPQVGGtIKQPPTN Cytochrom_B558a molecular association, regulation NOX4(INDUCES) 35051590 3 13 5 +BRMS1 BRMS1 Tumor suppressor Q9HCU9 25855 11q13.2 human S237-p 18007342 KKARAAVsPQKRKSD molecular association, regulation carcinogenesis, inhibited; cell motility, inhibited; transcription, inhibited SDS3(INDUCES); HDAC1(INDUCES); SIN3A(INDUCES) 34788285 1 10 1 +PDCD1 PD-1 Apoptosis; Membrane protein, integral Q15116 5133 2q37.3 human K210-ub 1877141201 RRTGQPLkEDPSAVP protein degradation 33109719 1 0 0 +BCL3 Bcl-3 Apoptosis; Nuclear receptor co-regulator; Oncoprotein; Transcription regulation P20749 602 19q13.32 human K21-ub 3627524 VDLRTRPkAAGLPGA protein degradation transcription, altered 15469820 1 1 0 +KCNQ1 Kv7.1 Channel, potassium; Membrane protein, integral; Membrane protein, multi-pass P51787 3784 11p15.5-p15.4 human T470-p 2999202 SSVRKSPtLLEVSMP activity, induced 12835205 1 1 0 +Ceacam1 CEACAM1 Cell adhesion; Immunoglobulin superfamily; Membrane protein, integral; Motility/polarity/chemotaxis P31809 26365 7 A3|7 13.84 cM mouse Y488-p 447777 NKVDDVAyTVLNFNS molecular association, regulation; intracellular localization cell growth, altered SHC1(INDUCES); SHP-2(INDUCES) 11694516; 14970258; 9867848 10 2 0 +PRMT5 PRMT5 Cell cycle regulation; EC 2.1.1.125; METHYLTRANSFERASE; Methyltransferase; Methyltransferase, protein arginine; RNA processing O14744 10419 14q11.2 human Y297-p 18545702 NRPPPNAyELFAKGY PRMT5 molecular association, regulation; enzymatic activity, inhibited carcinogenesis, altered; cell growth, altered PRMT5(DISRUPTS) 21316606 1 0 0 contributes to the mutant Jak2 V617F -induced myeloproliferative phenotype; negatively regulates hematopoietic stem/progenitor cell expansion and erythroid differentiation +NF1 NF1 iso2 GAP; GAP, Ras; Motility/polarity/chemotaxis; Nucleolus; Tumor suppressor P21359-2 4763 17q11.2 human S2578-p 456016 HLRKVSVsESNVLLD molecular association, regulation; activity, inhibited 14-3-3 beta(INDUCES) 14741381 1 1 2 +UBA52-RPS27A-UBB-UBC ubiquitin Ubiquitin-like modifier P62991 mouse S65-p 9765472 DYNIQKEsTLHLVLR ubiquitin molecular association, regulation; intracellular localization; enzymatic activity, induced autophagy, induced PARK2(INDUCES) 25474007; 33931895; 34030589 27 17 0 mitochondrial translocation and anchoring, mitophagy induced, mitochodrial degeneration ; Mitophagy induced; regulates mitochondrial homeostasis and pluripotency +RPS6KB1 p70S6K EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, AGC; Protein kinase, Ser/Thr (non-receptor); Translation P23443 6198 17q23.1 human T444-p 448358 RFIGSPRtPVSPVKF activity, induced; molecular association, regulation; enzymatic activity, induced cell cycle regulation; carcinogenesis, induced; cell growth, induced; cell adhesion, altered; signaling pathway regulation Tau iso8(NOT_REPORTED) 12759354; 15028555; 15051500; 15304500; 16364302; 21893193; 35077510; 7545671 106 37 109 PI3K/mTOR/p70S6K pathway +DNM1L DRP1 Apoptosis; EC 3.6.5.5; Endoplasmic reticulum; Hydrolase; Microtubule-binding; Mitochondrial; Motor O00429 10059 12p11.21 human Y449-p 297110001 IIQHCSNySTQELLR Dynamin_M activity, induced 29022905 1 0 0 oxidative stress-induced cell death in primary cortical neuron; increased GTPase activity +HSPA9 HSPA9B Chaperone; Heat shock protein; Nucleolus P38646 3313 5q31.2 human S65-p 483968 IDLGTTNsCVAVMEG HSP70 protein stabilization 17573779 1 0 0 ; phosphorylation of this site stabilizes HSPA9B, activates TTK and promotes centrosome re-duplication +Gap43 GAP43 Cell surface P06837 14432 16 B4|16 28.37 cM mouse S96-p 449105 TDAAPATsPKAEEPS Neuromodulin intracellular localization cell growth, induced; cytoskeletal reorganization 30240740 4 12 4 induces axon regeneration +CEP250 CEP250 Cell cycle regulation Q9BV73 11190 20q11.22 human S2392-p 4728455 AGLHHSLsHSLLAVA cell cycle regulation 20708153 1 2 0 +KDM1A LSD1 DEMETHYLASE; Demethylase; EC 1.-.-.-; Nuclear receptor co-regulator; Oxidoreductase; Transcription factor O60341 23028 1p36.12 human R838-m2 1879738504 GAMYTLPrQATPGVP protein stabilization; molecular association, regulation cell motility, induced USP7(INDUCES) 31833203 1 1 0 USP1 deubiquitinates and stabilizes LSD1, cell migration and invasion, CARM1 and USP7 regulate E-cadherin and vimentin expression +RAB7A Rab7 G protein; G protein, monomeric; G protein, monomeric, Rab P51149 7879 3q21.3 human Y183-p 449657 QETEVELyNEFPEPI molecular association, regulation; intracellular localization; phosphorylation cell motility, induced CCZ1(DISRUPTS); Vimentin(INDUCES) 26869029; 34066419 2 24 237 induces phosphorylation of AKT and PAK1, regulates NF-kB localization; Dephosphorylated Rab7 shows endosomal membrane localization. +MAP3K4 MEKK4 EC 2.7.11.25; KINASE; Kinase, protein; Protein kinase, STE; Protein kinase, Ser/Thr (non-receptor) Q9Y6R4 4216 6q26 human T1494-p 479428 KLKNNAQtMPGEVNS Pkinase enzymatic activity, induced 17242196 2 2 1 +CSF1R CSFR EC 2.7.10.1; KINASE; Kinase, protein; Membrane protein, integral; Oncoprotein; Protein kinase, TK; Protein kinase, tyrosine (receptor) P07333 1436 5q32 human Y561-p 450118 ESYEGNSyTFIDPTQ activity, induced; molecular association, regulation 11513742; 15297464; 7730365 10 1 6 +PLSCR1 PLSCR1 Calcium-binding; Membrane protein, integral O15162 5359 3q24 human Y74-p 464050 PVYNQPVyNQPVGAA molecular association, regulation; intracellular localization carcinogenesis, induced; cell growth, induced; transcription, induced SHC1(INDUCES); STAT3(INDUCES) DNA(INDUCES) 12871937; 32292520 3 0 1 induces binding to STAT1 promoter and STAT1 expression +Aurkc AurC EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, Other; Protein kinase, Ser/Thr (non-receptor) O88445 20871 7 A1|7 4.06 cM mouse T175-p 469107 RRKTMCGtLDYLPPE Pkinase enzymatic activity, inhibited 11879579 3 6 15 complex effects on enzymatic activity: mutation of T171 or T175 to alanine increases kinase activity, while double mutant is inactive. +Map2k1 MEK1 EC 2.7.12.2; KINASE; Kinase, protein; Protein kinase, STE; Protein kinase, dual-specificity (non-receptor) P31938 26395 9 C|9 34.55 cM mouse S298-p 448284 RTPGRPLsSYGMDSR Pkinase molecular association, regulation cell adhesion, altered; cell growth, altered ERK2(INDUCES) 12167697 25 4 1 +BPGM BPGM Carbohydrate Metabolism - glycolysis and gluconeogenesis; EC 3.1.3.13; EC 5.4.2.11; EC 5.4.2.4; Isomerase; Phosphatase (non-protein) P07738 669 7q33 human H11-p 27939400 YKLIMLRhGEGAWNK His_Phos_1 protein conformation 17052986 1 0 0 The enzyme conformation continuously changed during phosphoryl transfer process. +CHRM2 mAChR M2 GPCR, family 1; Membrane protein, integral; Membrane protein, multi-pass; Receptor, GPCR P08172 1129 7q33 human S286-p 459101 EKESSNDsTSVSAVA 7tm_1 receptor internalization, altered 9162044 3 0 0 Mutation of S286 T287 S288 S290 to A caused a faster rate and a greater extent of receptor internalization after agonist stimulation (transients only, not observed in stables). Mutation of all 8 sites prevented internalization (in both transients and stables). +Gucy1a1 GUCY1A1 EC 4.6.1.2; Guanylyl cyclase; Lyase; Nucleotide Metabolism - purine; Receptor, misc. P19686 497757 2q34 rat S64-p 3647001 SHPQRKTsRNRVYLH enzymatic activity, inhibited; phosphorylation 18635821 1 0 0 downregulates phosphorylation of VASP S239 +KRAS KRas G protein; G protein, monomeric; G protein, monomeric, Ras; Motility/polarity/chemotaxis; Oncoprotein P01116 3845 12p12.1 human Y64-p 5840743 DTAGQEEySAMRDQY Ras molecular association, regulation; protein conformation; activity, inhibited; phosphorylation cell growth, induced; signaling pathway regulation AGO2(INDUCES); BRAF(DISRUPTS) 26854235; 30644389; 34725361 3 5 3 regulates MAPK signaling +KCNH2 Kv11.1 Channel, potassium; Membrane protein, integral; Membrane protein, multi-pass; Motility/polarity/chemotaxis Q12809 3757 7q36.1 human S284-p 4696786 ASVRRASsADDIEAM activity, inhibited 29949809 1 9 0 reduces Kv11.1 mediated currents +MAD1L1 MAD1L1 Cell cycle regulation; Cytoskeletal Q9Y6D9 8379 7p22.3 human S546-p 1868914507 RTKVLHMsLNPTSVA MAD molecular association, regulation; intracellular localization cell cycle regulation; carcinogenesis, induced; chromatin organization, altered; cell growth, induced ZWILCH(INDUCES); ZW10(INDUCES); ROD1(INDUCES) 31291454 1 0 0 RZZ (Rod1-ZW10-ZWILCH) complex +BRAF BRAF EC 2.7.11.1; KINASE; Kinase, protein; Oncoprotein; Protein kinase, Ser/Thr (non-receptor); Protein kinase, TKL P15056 673 7q34 human S446-p 447804 KTLGRRDsSDDWEIP molecular association, regulation; protein conformation; enzymatic activity, induced carcinogenesis, induced; cell growth, induced HRas(INDUCES); BRAF(NOT_REPORTED) 15710605; 16803888; 19050761; 35173310 15 44 87 +Cish CISH O70512 83681 8q32 rat K120-ub 37044803 YLFTLSVkTTRGPTN SH2 protein degradation 25448846 1 0 0 +Irs2 IRS2 Adaptor/scaffold; Motility/polarity/chemotaxis P81122 384783 8 A1.1|8 5.35 cM mouse S1138-p 453435 GGRRRHSsETFSSTT protein stabilization; molecular association, regulation transcription, induced 14-3-3 gamma(INDUCES) 23615913 4 10 61 +NOS3 eNOS Amino Acid Metabolism - arginine and proline; EC 1.14.13.39; Oxidoreductase P29473 287024 cow S1179-p 447884 TSRIRTQsFSLQERH activity, induced; acetylation; molecular association, regulation; protein conformation; phosphorylation; enzymatic activity, induced apoptosis, inhibited; cell motility, altered Calmodulin(INDUCES); HSP90A(INDUCES) 10376602; 10514497; 10692402; 11278407; 11292821; 11988492; 12501214; 12591925; 12952971; 15319357; 16257964; 19251696; 20479254; 26560496; 26987903; 27613870; 33592314; 34474112 217 18 7 +TUBG1 TUBG1 Cytoskeletal; Motility/polarity/chemotaxis P23258 7283 17q21.2 human K344-ub 486350 LQRIRERkLANFIPW Tubulin_C intracellular localization cell cycle regulation; cytoskeletal reorganization 16166645 2 2 7 +PRKCZ PKCZ EC 2.7.11.13; KINASE; Kinase, protein; Protein kinase, AGC; Protein kinase, Ser/Thr (non-receptor) Q05513 5590 1p36.33 human Y417-p 14305100 TFCGTPNyIAPEILR Pkinase enzymatic activity, induced 20407013 1 0 0 +GNMT GNMT Amino Acid Metabolism - glycine, serine and threonine; EC 2.1.1.20; METHYLTRANSFERASE; Methyltransferase Q14749 27232 6p21.1 human S10-p 460706 DSVYRTRsLGVAAEG intracellular localization 30987732 2 7 0 +MITF MITF iso9 DNA-binding; Oncoprotein; Transcription factor O75030-9 4286 3p13 human S397-p 11126131 DPLLSSVsPGASKTS DUF3371 protein degradation 25605940 1 5 6 +PIK3R2 PIK3R2 Kinase, lipid; Motility/polarity/chemotaxis O00459 5296 19p13.11 human Y467-p 450387 YDQLYEEyTRTSQEL PI3K_P85_iSH2 carcinogenesis, induced; apoptosis, inhibited 35154579 1 13 165 +LIPE HSL EC 3.1.1.79; Lipase Q05469 3991 19q13.2 human S855-p 448804 EPMRRSVsEAALAQP molecular association, regulation; enzymatic activity, induced FABP4(INDUCES) 17785468; 19018281 27 28 1 +NFATC1 NFAT2 DNA-binding; Transcription factor O95644 4772 18q23 human S172-p 465577 YRDPSCLsPASSLSS intracellular localization transcription, inhibited 10652349; 24863062 2 0 0 +Ackr3 CMKOR1 GPCR, family 1; Membrane protein, integral; Membrane protein, multi-pass; Receptor, GPCR P56485 12778 1 D|1 45.28 cM mouse T352-p 4709314 DASRVSEtEYSALEQ protein degradation endocytosis, induced 30726732 2 3 0 promotes endocytosis and scavenging of CXCL12 and induced degradation of CXCR4 +Slc12a2 NKCC1 Membrane protein, integral; Membrane protein, multi-pass; Transporter; Transporter, SLC family P55012 20496 18 D3|18 32.15 cM mouse T205-p 455545 TNTYYLRtFGHNTMD AA_permease_N activity, induced; enzymatic activity, induced 17595523; 20463172; 26069258 20 15 13 Enzymatic activation by SLK3 requires two threonines separated by 4 amino acids. ; Ischemic cell death +KNL1 CASC5 Cancer Testis Antigen (CTA); Cell cycle regulation Q8NG31 57082 15q15.1 human T943-p 37046600 RQDDMEItRSHTTAL MELT phosphorylation 25402682 2 0 0 A mutants increased BUB1B S670 +Hdac2 HDAC2 DEACETYLASE; Deacetylase; EC 3.5.1.98; Nuclear receptor co-regulator; Transcription, coactivator/corepressor P70288 15182 10 19.44 cM|10 B1 mouse S394-p 449930 EDAVHEDsGDEDGED enzymatic activity, induced 21576649 6 87 52 +PRKN PARK2 EC 6.3.2.-; EC 6.3.2.19; Ligase; Translation; Translation regulation; UBIQUITIN LIGASE; Ubiquitin conjugating system; Ubiquitin ligase O60260 5071 6q26 human Y143-p 15624700 SPAGRSIyNSFYVYC ubiquitination; enzymatic activity, inhibited 20823226 1 1 0 inhibits PARK2 autoubiquitination +NFKB2 NFkB-p100 DNA-binding; Oncoprotein; Transcription factor Q00653 4791 10q24.32 human K863-sm 3055610 LPSTAEVkEDSAYGS protein processing; phosphorylation signaling pathway regulation 18617892 1 0 0 activation of alternative NF-kB pathway +EEF2K EEF2K EC 2.7.11.20; KINASE; Kinase, protein; Protein kinase, Ser/Thr (non-receptor); Protein kinase, atypical; Translation O00418 29904 16p12.2 human S70-p 7320074 LTKSERYsSSGSPAN enzymatic activity, inhibited carcinogenesis, induced; cell growth, induced; translation, induced 35513296 1 4 0 +Ptpra PTPRA EC 3.1.3.48; Membrane protein, integral; Motility/polarity/chemotaxis; PHOSPHATASE; Receptor protein phosphatase, tyrosine P18052 19262 2 F1|2 63.23 cM mouse S180-p 447611 QAGSHSNsFRLSNGR enzymatic activity, induced cytoskeletal reorganization 18809727 6 17 0 neurite outgrowth +DLGAP1 SAPAP1 Cytoskeletal O14490 9229 18p11.31 human S406-p 456941 KLQIRSHsYLRAVSE molecular association, regulation PSD-95(INDUCES) 22117215 2 1 1 Fluorescence Polarization +MAX MAX DNA-binding; Transcription factor P61244 4149 14q23.3 human S2-p 449307 ______MsDNDDIEV molecular association, regulation; activity, inhibited transcription, altered DNA(DISRUPTS) 37642402; 8018564 5 35 0 phosphorylation-deficient mutant inhibits transcription more efficiently +FADD FADD Adaptor/scaffold; Apoptosis Q13158 8772 11q13.3 human S200-p 40510683 MSPMSWNsDASTSEA intracellular localization 26253696 1 2 0 S200 is important for nuclear retention of FADD +Stap2 STAP2 Adaptor/scaffold Q8R0L1 106766 17|17 D mouse Y250-p 478353 PFLLDEDyEKVLGFV activity, induced 17368569 4 3 29 involved in the activation of STAT3 +STK38L NDR2 EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, AGC; Protein kinase, Ser/Thr (non-receptor) Q9Y2H1 23012 12p11.23 human T442-p 451133 DWVFLNYtYKRFEGL Pkinase_C molecular association, regulation; phosphorylation; enzymatic activity, induced cell growth, altered MST1(INDUCES); MOB1A(INDUCES); CCND1(INDUCES) 15037617; 16314523; 16488889; 23897809 4 2 8 +Grin2b NMDAR2B Channel, calcium; Channel, ligand-gated; Membrane protein, integral; Membrane protein, multi-pass Q00960 24410 4q43 rat S1480-p 454415 EKLSSIEsDV_____ NMDAR2_C molecular association, regulation; receptor internalization, altered cell growth, induced; apoptosis, inhibited DLG3(DISRUPTS); PSD-95(DISRUPTS) 15537897; 35928572 4 1 0 +HIF1A HIF1A Autophagy; DNA-binding; Transcription factor Q16665 3091 14q23.2 human K709-ac 28108000 PEEELNPkILALQNA activity, induced; molecular association, regulation; protein stabilization; ubiquitination carcinogenesis, induced; cell growth, induced; transcription, induced EGLN1(DISRUPTS) 22908229; 24681946 2 2 0 inhibits ubiquitination; regulates expression of hypoxic response target genes, inhibits HIF1A hydroxylation +CD247 CD3Z Membrane protein, integral; Receptor, misc. P20963 919 1q24.2 human Y153-p 455204 STATKDTyDALHMQA ITAM molecular association, regulation PI4K2A(INDUCES) 16337488 3 10 258 +Grik2 GluR6 Channel, calcium; Channel, ligand-gated; Membrane protein, integral; Membrane protein, multi-pass P42260 54257 20q13 rat K886-sm 12004405 PQAPVIVkTEEVINM neural plasticity; endocytosis, induced 17486098 4 0 0 +Foxo3 FOXO3A Autophagy; DNA-binding; Oncoprotein; Transcription factor Q9WVH4 56484 10 B2|10 22.79 cM mouse S252-p 449108 APRRRAVsMDNSNKY protein degradation; intracellular localization carcinogenesis, induced; cell growth, induced; apoptosis, inhibited; transcription, inhibited; translation, inhibited 21804606; 33795838; 34556581 37 19 76 +ADRA1D ADRA1D GPCR, family 1; Membrane protein, integral; Membrane protein, multi-pass; Receptor, GPCR P25100 146 20p13 human S516-p 1346843003 QLRAKVSsLSHKIRA receptor internalization, induced; molecular association, regulation; intracellular localization; receptor internalization, altered signaling pathway regulation ARRB1(INDUCES) 29551601; 30419287 2 1 0 triggers the calcium signaling pathway; regulates ERK signaling pathway, induces calcium signaling de-sensitization +LIMA1 eplin Actin-binding; Cytoskeletal; Motility/polarity/chemotaxis Q9UHB6 51474 12q13.12 human S362-p 455424 PVHPKPLsPDSRASS protein degradation; ubiquitination carcinogenesis, induced; cell adhesion, induced; cytoskeletal reorganization; cell motility, inhibited 23188829; 28465438 3 69 83 E-cadherin down regulation, EMT; formation of large plasma membrane ruffles that are characterized by highly dynamic actin rearrangements in their lamellipodia +RAD9A RAD9A Apoptosis; Cell cycle regulation; DNA replication; Deoxyribonuclease; EC 3.1.11.2 Q99638 5883 11q13.2 human Y28-p 447825 SRIGDELyLEPLEDG Rad9 molecular association, regulation apoptosis, induced Bcl-xL(INDUCES) 11971963 1 0 0 +BRCA1 BRCA1 EC 6.3.2.-; Nuclear receptor co-regulator; Transcription, coactivator/corepressor; Tumor suppressor; UBIQUITIN LIGASE; Ubiquitin conjugating system; Ubiquitin ligase P38398 672 17q21.31 human S1191-p 10272402 GELSRSPsPFTHTHL protein stabilization; molecular association, regulation; intracellular localization cell growth, induced; DNA repair, inhibited PIN1(INDUCES) 19683496; 21706030; 32193285 4 13 3 +Mknk1 Mnk1 EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, CAMK; Protein kinase, Ser/Thr (non-receptor); Translation O08605 17346 4|4 D1 mouse S396-p 11507614 GLCSMKLsPPSKSRL molecular association, regulation ERK1(INDUCES) 16162500 1 3 0 +LMNA lamin A/C Cytoskeletal P02545 4000 1q22 human S525-p 465453 NTWGCGNsLRTALIN LTD cytoskeletal reorganization 7925482 2 2 0 affects perinuclear assembly, dissasembly of lamin +PTTG1IP PTTG1IP Membrane protein, integral P53801 754 21q22.3 human Y174-p 454097 LFKEENPyARFENN_ molecular association, regulation; intracellular localization SLC5A5(INDUCES) 23678037 1 39 1992 +Cav1 caveolin-1 Adaptor/scaffold; Motility/polarity/chemotaxis; Nuclear receptor co-regulator P41350 25404 4q21 rat Y14-p 448422 VDSEGHLyTVPIREQ activity, induced; molecular association, regulation; intracellular localization endocytosis, altered RHOA(INDUCES) 10585286; 17121865; 19543529 55 45 830 activates fibronectin secretion; insulin receptor was endocytosed with Y14 phosphorylated caveolin-1 +SNAI1 Snail1 C2H2-type zinc finger protein; Transcription factor O95863 6615 20q13.13 human K187-ac 63359900 CVCGTCGkAFSRPWL zf-C2H2 protein degradation; molecular association, regulation; ubiquitination carcinogenesis, induced; transcription, induced BTRC(INDUCES); FBXL14(INDUCES); BRD4(INDUCES) 28296173; 31311807 2 0 0 BRD4 interacts with acetylated Snail to suppress its ubiquitination and degradation by competing with FBXL14 and BRD8 for binding to Snail1 ; regulates epithelial to mesenchymal transition (EMT) in lung cancer cells +TARDBP TDP-43 RNA-binding Q13148 23435 1p36.22 human K192-ac 38520207 DEPLRSRkVFVGRCT molecular association, regulation; phosphorylation transcription, inhibited RNA(DISRUPTS) 25556531; 32409664 2 1 0 enhances TDP-43 phosphorylation, enhances accumulation of TDP-43 aggregates; TDP-43-induced cell toxicity +STXBP1 STXBP1 Vesicle P61764 6812 9q34.11 human Y145-p 456431 LPYESQVySLDSADS Sec1 molecular association, regulation STX1A(INDUCES) 23962429 1 1 0 +NR4A1 Nur77 Apoptosis; DNA-binding; Nuclear receptor P22736 3164 12q13.13 human S431-p 21697917 IPGFAELsPADQDLL Hormone_recep molecular association, regulation cell cycle regulation; transcription, induced PIN1(INDUCES) 22002310 1 0 0 +PKM PKM Carbohydrate Metabolism - glycolysis and gluconeogenesis; Carbohydrate Metabolism - pyruvate; EC 2.7.1.40; KINASE; Kinase, other; Mitochondrial; Nucleotide Metabolism - purine P14618 5315 15q23 human S100-p 4708572 TATESFAsDPILYRP PK intracellular localization 34244606 1 13 25 +DDX41 DDX41 EC 3.6.4.13; Helicase; RNA splicing; RNA-binding; Spliceosome Q9UJV9 51428 5q35.3 human Y414-p 40253300 DVIQEVEyVKEEAKM molecular association, regulation STING(INDUCES) DNA(INDUCES) 25704810 2 2 0 +MTHFD2 MTHFD2 Carbohydrate Metabolism - glyoxylate and dicarboxylate; Cofactor and Vitamin Metabolism - one carbon pool by folate; EC 1.5.1.15; EC 3.5.4.9; Hydrolase; Mitochondrial; Oxidoreductase P13995 10797 2p13.1 human K88-ac 1876877400 SHSYVLNkTRAAAVV THF_DHG_CYH enzymatic activity, inhibited 32811824 1 1 0 +RIPK3 RIPK3 EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, Ser/Thr (non-receptor); Protein kinase, TKL Q9Y572 11035 14q12 human K501-ub 1881250302 VGSQEGPkDPEAWSR protein degradation 33953350 1 0 0 TNF-induced necrosis +Ppp2r5b PPP2R5B Motility/polarity/chemotaxis; Protein phosphatase, regulatory subunit Q6PD28 225849 19|19 A mouse S47-p 10405468 RPRRSHSsSQFRYQS molecular association, regulation; phosphorylation PPP2CA(INDUCES); PPP2R5B(INDUCES) 21329884 1 4 7 PPP2R2R5B phosphorylation by CLK2 is required for the PPP2CA-AKT complex; induces AKT dephosphorylation +H1-2 H1C DNA-binding P16403 3006 6p22.2 human K46-ub 486641 PVSELITkAVAASKE Linker_histone carcinogenesis, induced 30517763 1 12 105 +Llgl1 LLGL1 Cell adhesion; Cytoskeletal; Motility/polarity/chemotaxis Q80Y17 16897 11 B2|11 37.81 cM mouse S662-p 449917 LKKSLRQsFRRIRKS intracellular localization 11809830 3 16 8 +RELA NFkB-p65 DNA-binding; Nuclear receptor co-regulator; Transcription factor Q04206 5970 11q13.1 human T322-gl 5148300 KSPFSGPtDPRPPPR molecular association, regulation transcription, induced DNA(INDUCES) 25915426 3 1 0 +MAT1A MAT1A Amino Acid Metabolism - cysteine and methionine; EC 2.5.1.6; Other Amino Acids Metabolism - selenoamino acid; Transferase Q00266 4143 10q22.3 human T202-p 1874404504 VIPVRIHtIVISVQH S-AdoMet_synt_M protein degradation; molecular association, regulation; intracellular localization carcinogenesis, induced; cell motility, induced; cell growth, induced; transcription, induced 14-3-3 zeta(INDUCES) 34349244 1 0 0 +SCN9A SCN9A iso3 Channel, sodium; Membrane protein, integral; Membrane protein, multi-pass Q15858-3 6335 2q24.3 human I848-p 1871432202 LNMLIKIiGNSVGAL Ion_trans activity, induced; protein conformation 33361158 1 0 0 +ADRB1 ADRB1 GPCR, family 1; Membrane protein, integral; Membrane protein, multi-pass; Receptor, GPCR P08588 153 10q25.3 human S312-p 469625 RAGKRRPsRLVALRE 7tm_1 receptor internalization, induced; molecular association, regulation; receptor desensitization, altered; receptor recycling, induced; intracellular localization; receptor recycling, altered DLG1(INDUCES) 14990580; 16940053; 17170109; 24121510; 24324269; 27816670 7 2 0 ADRB1 sorting from endosomes to the plasma membrane +AQP2 AQP2 Channel, misc.; Membrane protein, integral; Membrane protein, multi-pass; Transporter; Transporter, aquaporin family P41181 359 12q13.12 human S261-p 464644 RQSVELHsPQSLPRG molecular association, regulation; intracellular localization exocytosis, induced HSP70(DISRUPTS); VTA1(DISRUPTS) 22778181; 28710278; 29145196; 32529500 38 9 0 +STK11 LKB1 Autophagy; EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, CAMK; Protein kinase, Ser/Thr (non-receptor); Tumor suppressor Q15831 6794 19p13.3 human K64-ac 56714902 EGSYGKVkEVLDSET Pkinase protein degradation; molecular association, regulation; ubiquitination; intracellular localization cell cycle regulation; apoptosis, induced; transcription, induced; cell growth, altered SIRT1(INDUCES); STRAD(DISRUPTS); HERC2(INDUCES) DNA(INDUCES) 27259994 1 0 0 +YAP1 YAP1 Oncoprotein; Transcription, coactivator/corepressor P46937 10413 11q22.1 human K97-sm 6094306 KLPDSFFkPPEPKSH protein stabilization; ubiquitination apoptosis, induced; transcription, induced 19111660 1 0 0 inhibits ubiquitination +ARHGEF2 ARHGEF2 GEF; GEF, Rac/Rho; Motility/polarity/chemotaxis Q92974 9181 1q22 human S151-p 1211018 LSLAKSVsTTNIAGH activity, induced; molecular association, regulation; intracellular localization cell adhesion, induced; cytoskeletal reorganization 14-3-3 zeta(INDUCES); DYNLT1(DISRUPTS) 29089450 1 42 19 +SCFD1 SCFD1 Vesicle Q8WVM8 23256 14q12 human S316-p 27461658 PKRKNKKsYDLTPVD Sec1 molecular association, regulation autophagy, induced PCAF(DISRUPTS) 35465820 1 6 0 SCFD1 phosphorylation promotes its deacetylation +PRKAA1 AMPKA1 Autophagy; EC 2.7.11.1; EC 2.7.11.26; EC 2.7.11.27; EC 2.7.11.31; KINASE; Kinase, protein; Protein kinase, CAMK; Protein kinase, Ser/Thr (non-receptor) Q13131 5562 5p13.1 human K396-ub 21128822 LDELNPQkSKHQGVR enzymatic activity, inhibited 31996460 1 4 0 +Id2 ID2 DNA-binding; Transcription, coactivator/corepressor P41136 15902 12 A1.3|12 8.57 cM mouse T27-p 4706880 LGISRSKtPVDDPMS molecular association, regulation cell growth, inhibited VHL(DISRUPTS) 26735018 3 2 0 +Cdk1 CDK1 Cell cycle regulation; EC 2.7.11.22; EC 2.7.11.23; KINASE; Kinase, protein; Motility/polarity/chemotaxis; Protein kinase, CMGC; Protein kinase, Ser/Thr (non-receptor) P11440 12534 10 B5.3|10 36.07 cM mouse Y15-p 447610 EKIGEGTyGVVYKGR Pkinase enzymatic activity, inhibited cell cycle regulation; carcinogenesis, induced; carcinogenesis, inhibited; carcinogenesis, altered; cell growth, inhibited; cell growth, induced; cell growth, altered 11500387; 1655417; 17554083; 19917613; 32209571; 33761914; 35508654; 36116740; 36223752; 36959566 201 145 3902 +RARG RARG DNA-binding; Nuclear receptor P13631 5916 12q13.13 human S79-p 455544 EMVPSSPsPPPPPRV activity, induced transcription, induced 10748061 3 0 0 Transactivation of mRARb2 promoter +PPP1R12A MYPT1 Motility/polarity/chemotaxis; PHOSPHATASE; Protein phosphatase, regulatory subunit O14974 4659 12q21.2-q21.31 human S585-gl 1868585003 SAAGLQKsLLSSTST molecular association, regulation; phosphorylation cell cycle regulation PLK1(DISRUPTS) 32295844 1 1 0 inhibits CDK1-dependent phosphorylation at MYPT1 S473, regulates mitotic progression and centrosome integrity +Ctnnb1 CTNNB1 Actin-binding; Cell adhesion; Motility/polarity/chemotaxis; Nuclear receptor co-regulator; Oncoprotein; Transcription factor Q02248 12387 9 F4|9 72.19 cM mouse Y670-p 469563 SEDKPQDyKKRLSVE activity, induced carcinogenesis, induced; transcription, induced 37029299 3 1 15 +AKT1 Akt1 EC 2.7.11.1; KINASE; Kinase, protein; Oncoprotein; Protein kinase, AGC; Protein kinase, Ser/Thr (non-receptor) P31749 207 14q32.33 human T305-gl 25538002 EGIKDGAtMKTFCGT Pkinase enzymatic activity, inhibited; phosphorylation 22629392 1 1 0 suppresses Akt phosphorylation at T308 by disrupting its interaction with PDK1 +Lpin1 LPIN1 EC 3.1.3.4; Phosphatase, lipid Q91ZP3 14245 12 A1.1|12 7.9 cM mouse S287-p 471347 PSTPKSDsELVSKSA molecular association, regulation; intracellular localization 14-3-3 beta(INDUCES) 30617183 2 6 0 +ACTR2 ARP2 Actin-binding; Cytoskeletal; Motility/polarity/chemotaxis P61160 10097 2p14 human T237-p 36440502 EQKLALEtTVLVESY Actin intracellular localization carcinogenesis, induced; cell motility, induced; cytoskeletal reorganization 25601402; 27872092; 33755220 5 0 0 +MFF MFF Membrane protein, integral; Mitochondrial Q9GZY8 56947 2q36.3 human S157-p 470754 LKRERSMsENAVRQN Miff molecular association, regulation 14-3-3 beta(INDUCES) 21725060 2 51 55 mutation of this site prevents 14-3-3 binding (pan-14-3-3 antibody) +Syk Syk EC 2.7.10.2; KINASE; Kinase, protein; Protein kinase, TK; Protein kinase, tyrosine (non-receptor) Q64725 25155 17p14 rat Y342-p 447659 LPMDTEVyESPYADP enzymatic activity, induced 12417718 15 12 112 +Pde4d PDE4D EC 3.1.4.53; Nucleotide Metabolism - purine; Phosphodiesterase Q01063 238871 13 D2.1|13 59.69 cM mouse S136-p 483644 SFLYRSDsDYDLSPK phosphorylation; enzymatic activity, induced 25918234 3 24 3 regulates CAMP concentration and insulin secretion, regulates phosphorylation of CRTCs +Axin1 axin 1 Adaptor/scaffold; Tumor suppressor O35625 12005 17 A3.3|17 13.07 cM mouse K861-sm 2407409 KIIGKVEkVD_____ protein stabilization; enzymatic activity, induced 12223491; 18632848 2 0 0 induces JNK activity; prevents ubiquitination +Tbx21 TBX21 DNA-binding; Transcription factor Q9JKD8 57765 11|11 D mouse Y76-p 64227001 RFLGSFAyPPRAQVA transcription, induced 28424242 1 1 0 induce IFN-gamma expression +YAP1 YAP1 Oncoprotein; Transcription, coactivator/corepressor P46937 10413 11q22.1 human K90-ub 964556214 TVPMRLRkLPDSFFK protein degradation carcinogenesis, altered 36271031 2 1 0 +Mlxipl ChREBP Transcription factor Q8VIP2 171078 12q12 rat S627-p 458375 SGSERRPsGDLNSIQ transcription, altered 11698644 2 12 0 inhibits the DNA-binding activity of ChREBP +IGF2BP1 IGF2BP1 RNA-binding; Translation Q9NZI8 10642 17q21.32 human K450-ub 15390813 PPETPDSkVRMVIIT KH_1 carcinogenesis, induced; cell growth, induced 34779401 1 8 14 hepatocarcinogenesis +DLG4 PSD-95 Adaptor/scaffold P78352 1742 17p13.1 human Y397-p 473889 AQYKPEEySRFEAKI molecular association, regulation; protein conformation Stargazin(INDUCES) 24587199; 28692247 3 1 6 regulates binding affinity; phosphorylation at Y397 induced a signi?cant increase in a?nity +GORASP2 GRASP55 Motility/polarity/chemotaxis; Vesicle Q9H8Y8 26003 2q31.1 human K50-ac 33349525 INGSRLNkDNDTLKD molecular association, regulation GRASP55(DISRUPTS) 31604796 1 2 0 Golgi fragmentation, K50 deacetylation is required for post-mitotic Golgi structure formation, GRASP55 deacetylation facilitates self-interaction +RPS6KB1 p70S6K iso2 EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, AGC; Protein kinase, Ser/Thr (non-receptor); Translation P23443-2 6198 17q23.1 human S424-p 448357 GSPRTPVsPVKFSPG protein conformation 30612880 102 54 247 +Rhoa RHOA G protein; G protein, monomeric; G protein, monomeric, Rho; Motility/polarity/chemotaxis; Oncoprotein Q9QUI0 11848 9|9 F1-F2 mouse Y42-p 150180312 VPTVFENyVADIEVD Ras molecular association, regulation cell growth, induced VAV2(INDUCES); RhoGDI alpha(DISRUPTS); IKKG(INDUCES) 28712859 7 0 0 may be involved in tumorigenesis +Plk1 PLK1 EC 2.7.11.21; KINASE; Kinase, protein; Protein kinase, Other; Protein kinase, Ser/Thr (non-receptor) Q07832 18817 7 F2|7 65.52 cM mouse T210-p 448139 YEGERKKtLCGTPNY Pkinase intracellular localization; enzymatic activity, induced cell cycle regulation 25658810; 26755576; 33901174 59 31 45 +SNCAIP SNCAIP Vesicle Q9Y6H5 9627 5q23.2 human S215-p 2873901 CVLSPVKsPHLRKAS molecular association, regulation PIN1(INDUCES) 16365047 1 0 0 +FRS2 FRS2 Adaptor/scaffold Q8WU20 10818 12q15 human Y392-p 449785 NLDPMHNyVNTENVT molecular association, regulation cell differentiation, induced SOS1(INDUCES); GRB2(INDUCES) 11278583 3 2 26 +Kcnk18 KCNK18 Channel, ligand-gated; Channel, potassium; Membrane protein, integral; Membrane protein, multi-pass Q6VV64 332396 19|19 D3 mouse S274-p 13383300 ELVLGRLsCSILSNL activity, inhibited 20215114; 22145024 4 0 0 K+ channel activity inhibited +Map2 MAP2 iso3 Cytoskeletal; Motility/polarity/chemotaxis P15146-3 25595 9q32 rat T262-p 450182 RTPGTPGtPSYPRTP cytoskeletal reorganization 10826493 3 19 17 caused decrease in microtubule bundles +CDK12 CDK12 Cell cycle regulation; EC 2.7.11.22; EC 2.7.11.23; KINASE; Kinase, protein; Motility/polarity/chemotaxis; Protein kinase, CMGC; Protein kinase, Ser/Thr (non-receptor); RNA splicing; Spliceosome Q9NYV4 51755 17q12 human T893-p 472551 SEESRPYtNKVITLW Pkinase protein conformation; enzymatic activity, induced 24662513 1 55 27 +CCNA2 CCNA2 Cell cycle regulation; Nuclear receptor co-regulator P20248 890 4q27 human K95-ac 7761216 PPWKANSkQPAFTIH Cyclin_N2 protein degradation; molecular association, regulation cell cycle regulation CDK2(DISRUPTS) 19483727; 23760262 2 1 0 +Map4 MAP4 Cytoskeletal; Motility/polarity/chemotaxis P27546 17758 9 F2|9 59.83 cM mouse S1046-p 470381 KAQAKVGsLDNVGHL Tubulin-binding molecular association, regulation cytoskeletal reorganization MAP4(INDUCES) 34040253 3 88 1 regulates microtubule detyrosination +Ceacam20 CEACAM20 Immunoglobulin superfamily; Membrane protein, integral Q9D2Z1 71601 7|7 A3 mouse Y559-p 41604100 GRNEESNyEKLLNSN transcription, induced 26195794 1 1 0 increase in IL-8 production +NHERF1 NHERF Adaptor/scaffold; Motility/polarity/chemotaxis O14745 9368 17q25.1 human S302-p 468296 EELNSQDsPPKQDST EBP50_C molecular association, regulation; protein conformation cell cycle regulation; cell growth, inhibited; apoptosis, induced; cytoskeletal reorganization; cell adhesion, inhibited ACTB(INDUCES) 23775624; 30326259 4 36 45 increased cell invasion, regulates invadopodial activity, cell proliferation inhibited, development of VM network, regulates metastatic potency and organotropism +SMN1 SMN RNA processing; RNA-binding Q16637 6606 5q13.2 human S28-p 454315 FRRGTGQsDDSDIWD SMN activity, induced; molecular association, regulation; intracellular localization coilin(INDUCES); SMN(INDUCES) 15592453; 20878088; 24602413 3 78 27 +F2RL1 F2RL1 GPCR, family 1; Membrane protein, integral; Membrane protein, multi-pass; Receptor, GPCR P55085 2150 5q13.3 human S389-p 34607194 KSSSYSSsSTTVKTS receptor desensitization, induced; molecular association, regulation; phosphorylation signaling pathway regulation ARRB1(INDUCES); ARRB2(INDUCES) 33073187 1 0 1 inhibits ERK phosphorylation and signaling; regulates calcium signaling +PRDX6 PRDX6 Amino Acid Metabolism - phenylalanine; EC 1.11.1.15; EC 1.11.1.9; Energy Metabolism - methane; Oxidoreductase; Phospholipase P30041 9588 1q25.1 human K122-sm 62925700 GMLDPAEkDEKGMPV AhpC-TSA sumoylation; protein degradation 28055018 1 0 0 +Creb1 CREB DNA-binding; Transcription factor Q01147 12912 1 C2|1 32.74 cM mouse S129-p 448548 KILNDLSsDAPGVPR pKID neural plasticity; transcription, induced 34607805 5 1 0 +CCND2 CCND2 Cell cycle regulation; Motility/polarity/chemotaxis P30279 894 12p13.32 human T280-p 469202 DELDQAStPTDVRDI Cyclin_C protein degradation cell cycle regulation; cell growth, inhibited 17486076; 24705253; 27843138 4 3 11 phosphodeficient mutants show increased proliferation; CCND2 T280A significantly increased cell growth +IRF1 IRF1 Transcription factor; Tumor suppressor P10914 3659 5q31.1 human K39-ub 31914112 MIFQIPWkHAAKHGW IRF protein degradation; molecular association, regulation DNA(DISRUPTS) 23134341 1 2 0 +DHCR24 Diminuto EC 1.3.1.72; Lipid Metabolism - steroid biosynthesis; Membrane protein, integral; Oxidoreductase Q15392 1718 1p32.3 human T110-p 476314 RVGKYKKtHKNIMIN FAD_binding_4 enzymatic activity, induced 24363437 1 1 1 +RB1 Rb Nuclear receptor co-regulator; Oncoprotein; Transcription, coactivator/corepressor; Tumor suppressor P06400 5925 13q14.2 human S608-p 447976 TAADMYLsPVRSPKK molecular association, regulation; protein conformation cell cycle regulation; cell growth, induced; apoptosis, inhibited E2F1(DISRUPTS); RAF1(INDUCES) 20223825; 22279936; 27331409; 9315635 13 10 30 +LIMD1 LIMD1 Motility/polarity/chemotaxis; Tumor suppressor Q9UGP4 8994 3p21.31 human S424-p 3214995 VLLDSPSsPRVRLPC cell cycle regulation; carcinogenesis, inhibited; cell growth, inhibited; cell motility, inhibited 30600590 1 12 3 mitotic phosphorylation required for mitotic progression +PRPS2 PRPS2 Carbohydrate Metabolism - pentose phosphate pathway; EC 2.7.6.1; Kinase, other; Nucleotide Metabolism - purine P11908 5634 Xp22.2 human T285-p 1874748502 EDKMKHCtKIQVIDI Pribosyl_synth protein degradation; molecular association, regulation; ubiquitination carcinogenesis, inhibited; cell growth, inhibited TRAF2(INDUCES) 34465890 1 1 0 +CSF3R GCSFR Membrane protein, integral; Receptor, cytokine Q99062 1441 1p34.3 human Y767-p 451835 TSPGPGHyLRCDSTQ molecular association, regulation; activity, inhibited SHIP(INDUCES); SHC1(INDUCES); STAT3(INDUCES); CISH(INDUCES) 15470047; 16493051 5 0 0 +Syn1 SYN1 Vesicle P09951 24949 Xq11 rat T337-p 486180 SVSGNWKtNTGSAML Synapsin_C molecular association, regulation; intracellular localization neural plasticity; signaling pathway regulation SYP(DISRUPTS) 31148170 1 2 0 regulating glutamate release +BACH2 BACH2 DNA-binding; Transcription factor Q9BYV9 60468 6q15 human K421-sm 2798316 PGLEALCkQEGELDR intracellular localization 18201693 2 0 0 mobility of nuclear domains +ATAT1 ATAT1 ACETYLTRANSFERASE; Acetyltransferase; EC 2.3.1.108 Q5SQI0 79969 6p21.33 human S237-p 1095631200 GDIKPYSsSDREFLK acetylation; enzymatic activity, induced cell growth, inhibited 29703898 1 0 0 +ESR1 ER-alpha DNA-binding; Nuclear receptor; Transcription factor P03372 2099 6q25.1-q25.2 human K299-sm 27992516 WPSPLMIkRSKKNSL transcription, inhibited 22826433 1 1 0 ER-alpha SUMOylation suppresses ER transcriptional activation by full antiestrogens (AEs) in the absence of induced ER degradation +HDAC2 HDAC2 DEACETYLASE; Deacetylase; EC 3.5.1.98; Nuclear receptor co-regulator; Transcription, coactivator/corepressor Q92769 3066 6q21 human K75-ac 11320706 YHSDEYIkFLRSIRP Hist_deacetyl molecular association, regulation; phosphorylation; enzymatic activity, induced transcription, induced lamin A/C(INDUCES); CK2A1(INDUCES) 24526703; 32698523 2 2 0 Lamin A/C binds PCAF and HDAC2 in committed C2C12 ; induces hypertrophic phenotypes in cardiomyocytes, induces phosphorylation at HDAC2- S394 +Mlxipl ChREBP Transcription factor Q99MZ3 58805 5|5 G2 mouse S514-p 4772264 SPGGQKAsPPTLASA transcription, induced 28450420 1 3 0 S514 phosphorylation could enhance ChREBP O-GlcNAcylation +SIRT1 SIRT1 Apoptosis; DEACETYLASE; Deacetylase; EC 3.5.1.-; Nuclear receptor co-regulator Q96EB6 23411 10q21.3 human K499-ub 15397645 RLGGEYAkLCCNPVK protein degradation carcinogenesis, inhibited; cell growth, inhibited; cell motility, inhibited 32361710 1 4 1 +CDCA5 CDCA5 Cell cycle regulation Q96FF9 113130 11q13.1 human T115-p 469416 VPATPTStPVPNPEA Sororin molecular association, regulation; activity, inhibited cell cycle regulation SCC-112(DISRUPTS); H2A.1(DISRUPTS); SMC3(DISRUPTS) 21878504; 23901111 2 6 15 +ASAP1 DDEF1 GAP; GAP, ARF; Motility/polarity/chemotaxis Q9ULH1 50807 8q24.21-q24.22 human Y767-p 450438 RDKQRLSyGAFTNQI cell motility, induced 25682866 5 0 0 +Lrrk2 LRRK2 EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, Ser/Thr (non-receptor); Protein kinase, TKL Q5S006 66725 15|15 E3 mouse S1292-p 13204416 PNEMGKLsKIWDLPL LRR_4 autophagy, induced; apoptosis, induced; signaling pathway regulation 37269951 15 3 0 regulates the LRRK2-RAB10-NLRP3 pathway +Tgfbr1 TGFBR1 EC 2.7.11.30; KINASE; Kinase, protein; Membrane protein, integral; Protein kinase, Ser/Thr (receptor); Protein kinase, TKL; Receptor, misc. Q64729 21812 4 B1|4 26.02 cM mouse S165-p 448244 VPNEEDPsLDRPFIS apoptosis, induced; cell growth, altered 8947046 3 4 0 +HSF1 HSF1 DNA-binding; Transcription factor Q00613 3297 8q24.3 human S216-p 4668102 IPLMLNDsGSAHSMP protein degradation; molecular association, regulation; ubiquitination; intracellular localization cell cycle regulation CDC20(INDUCES) 18794143; 19934326 4 3 1 binding between HSF1 and Cdc20 increases in p53 -/- cells; interaction of Cdc20 with HSF1 weakenes its interaction with Mad2 in the three-protein complex +KIN KIN C2H2-type zinc finger protein; DNA replication O60870 22944 10p14 human K135-m1 27278513 CKVDETPkGWYIQYI Kin17_mid molecular association, regulation; intracellular localization DNA(DISRUPTS) 24140279 1 2 2 relocalization from chromatin to cytosol +HDAC5 HDAC5 DEACETYLASE; Deacetylase; EC 3.5.1.98; Hydrolase Q9UQL6 10014 17q21.31 human S259-p 447995 FPLRKTAsEPNLKVR activity, induced; molecular association, regulation; enzymatic activity, inhibited; intracellular localization cell cycle regulation; apoptosis, induced; transcription, induced; transcription, altered; cell differentiation, altered; chromatin organization, altered; cell growth, induced; cell motility, altered HDAC3(DISRUPTS); 14-3-3 epsilon(INDUCES); TBL1X(DISRUPTS); TBL1XR1(DISRUPTS); GPS2(DISRUPTS); 14-3-3 beta(DISRUPTS); 14-3-3 beta(INDUCES); PRKD3(DISRUPTS); SMRT(DISRUPTS); N-CoR1(INDUCES); PRKD1(DISRUPTS); PRKD2(DISRUPTS) 11081517; 16980613; 18184930; 18332134; 18951085; 21081666; 22243750; 24120667; 24207022; 24841198; 25012661; 28343149; 32485181 25 23 25 +Th TH Amino Acid Metabolism - tyrosine; EC 1.14.16.2; Endoplasmic reticulum; Mitochondrial; Oxidoreductase; Vesicle P04177 25085 1q41 rat S31-p 448544 KQAEAVTsPRFIGRR TOH_N protein stabilization; enzymatic activity, induced 12124439; 1347949; 15228599; 15639226 43 8 0 Phosphorylation of S8 S19 and S31 (more stable) may stabilize TH already phosphorylated at S40 (least stable). +NCOA3 SRC-3 ACETYLTRANSFERASE; Acetyltransferase; EC 2.3.1.48; Motility/polarity/chemotaxis; Nuclear receptor co-regulator; Transcription, coactivator/corepressor Q9Y6Q9 8202 20q13.12 human T1067-p 4252800 LLSNTDAtGLEEIDR Nuc_rec_co-act protein stabilization; molecular association, regulation carcinogenesis, induced; transcription, induced ATF-4(INDUCES); PSMA3(DISRUPTS) DNA(INDUCES) 18313384; 31975428 2 1 0 induces binding to promoters of genes in the purine pathway; some subset of these 8 residues +PTEN PTEN Carbohydrate Metabolism - inositol phosphate; EC 3.1.3.16; EC 3.1.3.48; EC 3.1.3.67; Motility/polarity/chemotaxis; Nuclear receptor co-regulator; PHOSPHATASE; Phosphatase, lipid; Tumor suppressor P60484 5728 10q23.31 human T383-p 448315 HYRYSDTtDSDPENE molecular association, regulation; protein stabilization; intracellular localization; enzymatic activity, inhibited; protein conformation; phosphorylation; enzymatic activity, altered cell cycle regulation; neural plasticity; cell differentiation, altered; carcinogenesis, inhibited; chromatin organization, altered; cell motility, altered; transcription, altered PTEN(INDUCES); PTEN(DISRUPTS); AIP1(DISRUPTS) DNA(INDUCES) 10866658; 11035045; 11431330; 14976311; 17240336; 17565999; 22413754; 24766807; 25823029; 35240162; 36155262 23 3 0 induces EGFR degradation; regulates CHK1 phosphorylation and activation and H2AX phosphorylation +TLR4 TLR4 Membrane protein, integral; Receptor, misc. O00206 7099 9q33.1 human Y674-p 478360 YGRGENIyDAFVIYS TIR molecular association, regulation; phosphorylation transcription, induced IRAK1(DISRUPTS); MYD88(DISRUPTS) 17392283 3 1 0 IRAK1 short form +DRD1 DRD1 GPCR, family 1; Membrane protein, integral; Membrane protein, multi-pass; Receptor, GPCR P21728 1812 5q35.2 human S259-p 455303 ECSQPESsFKMSFKR 7tm_1 molecular association, regulation signaling pathway regulation G-alpha(s)(DISRUPTS); ARR3(INDUCES) 32503917 2 0 0 ERK1/2 activation +Grk2 GRK2 EC 2.7.11.15; KINASE; Kinase, protein; Protein kinase, AGC; Protein kinase, Ser/Thr (non-receptor) Q99MK8 110355 19 A|19 3.98 cM mouse S670-p 447725 KMKNKPRsPVVELSK molecular association, regulation cell motility, altered GIT1(DISRUPTS) 18369319 5 40 18 activates ERK signaling in response to S1P and fibronectin +CDK9 CDK9 Cell cycle regulation; EC 2.7.11.22; EC 2.7.11.23; KINASE; Kinase, protein; Nuclear receptor co-regulator; Protein kinase, CMGC; Protein kinase, Ser/Thr (non-receptor) P50750 1025 9q34.11 human S347-p 3681502 APPRRKGsQITQQST molecular association, regulation RNA(INDUCES) 10958691 3 24 90 HIV-1 TAR RNA +TRIO TRIO Apoptosis; EC 2.7.11.1; GEF; GEF, misc.; KINASE; Kinase, protein; Protein kinase, CAMK; Protein kinase, Ser/Thr (non-receptor) O75962 7204 5p15.2 human S2631-p 4715630 GTLKKSTsWHTALRL cytoskeletal reorganization 35290799 0 10 0 +PELI1 PELI1 Adaptor/scaffold; EC 6.3.2.-; EC 6.3.2.19; Ligase; UBIQUITIN LIGASE; Ubiquitin conjugating system; Ubiquitin ligase Q96FA3 57162 2p14 human S76-p 7388015 ISNKDQHsISYTLSR Pellino ubiquitination; enzymatic activity, induced 19264966 2 1 2 +MEF2C MEF2C DNA-binding; Transcription factor Q06413 4208 5q14.3 human S396-p 456980 NIKSEPVsPPRDRTT sumoylation; protein processing transcription, induced 15340086; 16478538 3 9 0 +Gata4 GATA4 Motility/polarity/chemotaxis; Transcription factor Q08369 14463 14 D1|14 33.24 cM mouse S105-p 449604 AYTPPPVsPRFSFPG GATA-N activity, induced; protein stabilization; molecular association, regulation; protein processing apoptosis, inhibited; transcription, induced; signaling pathway regulation DNA(INDUCES) 11585926; 21746915; 22674427; 23811561; 30793514 16 0 0 signaling pathway related to ECM genes; protein level and cell viability increased; protein ubiquitination decreased; induce testosterone production in male mouse; EPO-ERK signaling +PLK1 PLK1 EC 2.7.11.21; KINASE; Kinase, protein; Protein kinase, Other; Protein kinase, Ser/Thr (non-receptor) P53350 5347 16p12.2 human K492-sm 334535808 YMSEHLLkAGANITP protein stabilization; molecular association, regulation; intracellular localization cell cycle regulation CDH1(DISRUPTS) 29166606 1 0 0 blocking the SUMO acceptor site K492 led to numerous mitotic defects, including misaligned and/or mis-segregated chromosomes; nuclear import +YAP1 YAP1 Oncoprotein; Transcription, coactivator/corepressor P46937 10413 11q22.1 human S131-p 3190651 RAHSSPAsLQLGAVS cell growth, induced; transcription, inhibited 28416665 2 14 59 sensitivity to gemcitabine +SIK2 QIK EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, CAMK; Protein kinase, Ser/Thr (non-receptor) Q9H0K1 23235 11q23.1 human S358-p 487501 DGRQRRPsTIAEQTV molecular association, regulation; intracellular localization carcinogenesis, induced; cell motility, induced; cytoskeletal reorganization 14-3-3 beta(INDUCES) 22462548; 35278271 5 9 134 +PML PML iso4 Nucleolus; Oncoprotein; SUMO LIGASE; SUMO conjugating system; SUMO ligase; Transcription factor; Tumor suppressor; Ubiquitin conjugating system P29590-4 5371 15q24.1 human S40-p 451471 RQPSPSPsPTERAPA protein stabilization apoptosis, altered 15093545 1 10 0 Phosphorylation of PML is associated with enhanced sumoylation and apoptosis induced by As2O3. +GCK GK Carbohydrate Metabolism - amino sugar and nucleotide sugar; Carbohydrate Metabolism - galactose; Carbohydrate Metabolism - glycolysis and gluconeogenesis; Carbohydrate Metabolism - starch and sucrose; EC 2.7.1.2; Kinase, other; Mitochondrial P35557 2645 7p13 human K458-sm 27581517 LVSAVACkKACMLGQ protein stabilization; enzymatic activity, induced 23297408 1 1 0 +DNM1L DRP1 Apoptosis; EC 3.6.5.5; Endoplasmic reticulum; Hydrolase; Microtubule-binding; Mitochondrial; Motor O00429 10059 12p11.21 human K606-sm 9859922 EELLAEEkSKPIPIM activity, induced; intracellular localization 19638400 1 0 0 sumoylation is linked to its GTPase activity cycle, and influenced by DRP1 localization +PRKN PARK2 EC 6.3.2.-; EC 6.3.2.19; Ligase; Translation; Translation regulation; UBIQUITIN LIGASE; Ubiquitin conjugating system; Ubiquitin ligase O60260 5071 6q26 human S101-p 454420 GCEREPQsLTRVDLS phosphorylation 23256036 3 2 0 S9, S10, S101 might be priming phosphorylation sites for S65 phosphorylarion +CACNA1C CACNA1C iso4 Channel, calcium; Membrane protein, integral; Membrane protein, multi-pass P15381-4 rabbit S1570-p 467228 VACKRLVsMNMPLNS GPHH activity, induced 16820363 4 0 0 +MSX1 MSX1 DNA-binding; Motility/polarity/chemotaxis P28360 4487 4p16.2 human K15-sm 12004422 TSLPLGVkVEDSAFG cell differentiation, inhibited; transcription, inhibited 16600910 2 1 0 PIAS1 binding to MSX1 is required for inhibiting cell differentiation and transcriptional repression, but sumoylation is not required +CLASP2 CLASP2 Cytoskeletal; Motility/polarity/chemotaxis O75122 23122 3p22.3 human S1034-p 7990150 SISPFNKsALKEAMF cell cycle regulation 23045552 1 5 0 +Sox2 SOX2 Cell development/differentiation; DNA-binding; Transcription factor P48432 20674 3 A3|3 16.93 cM mouse K247-sm 12004415 GSMGSVVkSEASSSP sumoylation; molecular association, regulation transcription, inhibited DNA(DISRUPTS) 17097055; 19900357 3 0 0 +KCNK2 TREK-1 Channel, potassium; Membrane protein, integral; Membrane protein, multi-pass O95069 3776 1q41 human S348-p 456161 KETRRRLsVEIYDKF activity, inhibited 19622790; 22726831 8 5 0 current reduced by phosphorylation; lidocaine- treated cells +TRPM2 TRPM2 Channel, calcium; EC 3.6.1.13; Hydrolase; Membrane protein, integral; Membrane protein, multi-pass; Transporter O94759 7226 21q22.3 human K1216-ub 1881559700 VPTLASQkAAEEPDA apoptosis, induced 34903714 1 0 0 lncTRPM2-AS blocks the ubiquitylation of TRPM2 and inhibits autophagy induced apoptosis +Prkd2 PRKD2 EC 2.7.11.13; KINASE; Kinase, protein; Motility/polarity/chemotaxis; Protein kinase, CAMK; Protein kinase, Ser/Thr (non-receptor) Q8BZ03 101540 7|7 A2 mouse S711-p 449865 GEKSFRRsVVGTPAY Pkinase exocytosis, induced 21527521 5 28 63 in dense granules, platelet aggregation and thrombus formation +Met Met EC 2.7.10.1; KINASE; Kinase, protein; Membrane protein, integral; Oncoprotein; Protein kinase, TK; Protein kinase, tyrosine (receptor) P16056 17295 6 A2|6 7.83 cM mouse Y1232-p 448470 RDMYDKEyYSVHNKT PK_Tyr_Ser-Thr ubiquitination; enzymatic activity, induced carcinogenesis, induced; cell differentiation, induced; cell motility, induced; cell growth, induced 12244174; 19595710; 34580063; 37175792; 7708691 57 36 740 +STAT1 STAT1 DNA-binding; Transcription factor P42224 6772 2q32.2 human R31-m2 1668800 DSFPMEIrQYLAQWL STAT_int transcription, altered 11257227 1 0 0 +TP53 p53 Activator; DNA-binding; Motility/polarity/chemotaxis; Nuclear receptor co-regulator; Transcription factor; Tumor suppressor P04637 7157 17p13.1 human Y126-p 34824802 AKSVTCTySPALNKM P53 protein degradation; molecular association, regulation; activity, inhibited carcinogenesis, induced; DNA repair, inhibited HERC5(INDUCES) 25071020 1 0 0 promotes ISGylation +FUS hnRNP P2 DNA-binding; Nuclear receptor co-regulator; Oncoprotein; RNA splicing; RNA-binding; SUMO LIGASE P35637 2521 16p11.2 human S164-p 1878186702 QQNQYNSsSGGGGGG molecular association, regulation hnRNP P2(DISRUPTS) 35753345 1 1 0 +Scn5a SCN5A Channel, sodium; Membrane protein, integral; Membrane protein, multi-pass Q9JJV9 20271 9 F3|9 71.33 cM mouse S1937-p 1869500702 FRQQAGSsGLSDEDA activity, induced; molecular association, regulation FGF13(DISRUPTS); Calmodulin(DISRUPTS) 28882890 1 1 0 impairs FGF13-dependent regulation of NaV1.5 channel inactivation +CTNNB1 CTNNB1 Actin-binding; Cell adhesion; Motility/polarity/chemotaxis; Nuclear receptor co-regulator; Oncoprotein; Transcription factor P35222 1499 3p22.1 human K49-ub 486322 TAPSLSGkGNPEEED protein degradation carcinogenesis, inhibited; cell growth, inhibited; transcription, inhibited 16849322 1 0 0 K19 is primary site of ubquitination ; when both sites are mutated induces TCF transcription and transformation +CEBPD C/EBP-delta DNA-binding; Motility/polarity/chemotaxis P49716 1052 8q11.21 human S167-p 28852500 SPEPPRSsPRQTPAP cell motility, induced; transcription, induced 23993701 1 0 0 +SNAPIN SNAPIN Vesicle O95295 23557 1q21.3 human T117-p 28761202 NHSVAKEtARRRAML molecular association, regulation exocytosis, inhibited SNAP-25(DISRUPTS) 23949442 1 0 0 +CCP110 CP110 Cell cycle regulation O43303 9738 16p12.3 human S98-p 126835300 VRKAPNAsDFDQWEM CaM_bind cell cycle regulation 28562169 1 0 0 centrosome duplication +ETS1 Ets-1 DNA-binding; Motility/polarity/chemotaxis; Oncoprotein; Transcription factor P14921 2113 11q24.3 human T265-p 31087093 YDSCDRLtQSWSSQS Ets1_N_flank activity, induced; protein stabilization; molecular association, regulation carcinogenesis, induced; cell motility, induced; transcription, induced; signaling pathway regulation p300(INDUCES) DNA(INDUCES) 34023818 1 2 0 transcriptional activation of matrix metalloproteinase (MMP)-9; inhibits ubiquitination, regulates GSK3?/ETS1/MMP-9 signaling +Eif2s1 eIF2-alpha RNA-binding; Translation; Translation initiation Q6ZWX6 13665 12|12 C3 mouse S52-p 447635 MILLSELsRRRIRSI S1 activity, induced; activity, inhibited apoptosis, induced; transcription, induced; transcription, altered; autophagy, induced; translation, altered; apoptosis, inhibited; cytoskeletal reorganization; translation, induced; cell growth, altered; translation, inhibited 11430820; 12176355; 15184376; 17325203; 18063576; 19181853; 20559319; 20660158; 20924113; 23624402; 26549106; 27409837; 33567340; 34092754; 34560245; 34647267; 35466425; 35501370; 35758650 132 2 0 +Tp53 p53 Activator; DNA-binding; Motility/polarity/chemotaxis; Nuclear receptor co-regulator; Transcription factor; Tumor suppressor P02340 22059 11 B3|11 42.83 cM mouse K369-ub 464660 HSSYLKTkKGQSTSR transcription, altered 15964796 9 0 0 p53K6R (K378/383/369/379/367/370/R) mutant is still ubiquitinated and shows normal stability of p53 before and after DNA damage +Rph3a rabphilin 3A Vesicle P47708 19894 5|5 F mouse S234-p 455904 GPPTRRAsEARMSTA intracellular localization cytoskeletal reorganization 11466418; 28636945 5 0 2 polarization +GYS1 GYS1 Carbohydrate Metabolism - starch and sucrose; EC 2.4.1.11; Transferase P13807 2997 19q13.33 human S645-p 448238 RPASVPPsPSLSRHS Glycogen_syn enzymatic activity, inhibited; activity, inhibited signaling pathway regulation 19339242; 21668450; 22510711; 29541418 21 32 7 regulation of glycogen synthesis via R3F-PP1 signaling in astrocytoma cells +ILK ILK EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, Ser/Thr (non-receptor); Protein kinase, TKL Q13418 3611 11p15.4 human T173-p 479406 DTFWKGTtRTRPRNG intracellular localization cell motility, altered; signaling pathway regulation 17420447; 22521536 7 1 1 PKCA-ILK signaling pathway for growth cone collapse, RGC axon guidance, repulsive axon turning induced by Shh +NFATC1 NFAT2 DNA-binding; Transcription factor O95644 4772 18q23 human S294-p 448863 PHGSPRVsVTDDSWL intracellular localization; activity, inhibited 12351631 1 0 0 +NRBF2 NRBF2 Autophagy; Nuclear receptor co-regulator; Transcription, coactivator/corepressor Q96F24 29982 10q21.3 human S113-p 7446822 AEDAEGQsPLSQKYS NRBF2 molecular association, regulation; enzymatic activity, inhibited autophagy, induced ULK1(DISRUPTS); beclin 1(DISRUPTS); ATG13(DISRUPTS); ATG14(DISRUPTS); PIK3R4(INDUCES); PIK3C3(INDUCES); RB1CC1(DISRUPTS) 28059666 1 11 0 controls ULK1 complex association and PtdIns3K complex assembly, decreases PtdIns3K lipid kinase activity +Kif5b KIF5B Microtubule-binding; Motor Q61768 16573 18 A1|18 4.46 cM mouse S175-p 29603400 CTERFVCsPDEVMDT Kinesin activity, inhibited 24072715 2 1 0 autoinhibition is stabilized, reduces the stall force, tunes the direction of two-motor transport +SP1 SP1 C2H2-type zinc finger protein; DNA-binding; Transcription factor P08047 6667 12q13.13 human S641-p 470040 GKVYGKTsHLRAHLR zf-C2H2 activity, induced; molecular association, regulation transcription, induced; transcription, altered Rb-like 1(DISRUPTS) 16943418; 19464346 3 1 0 +HMGN1 HMGN1 DNA-binding; Nuclear receptor co-regulator P05114 3150 21q22.2 human K55-ac 458851 KKVQTKGkRGAKGKQ HMG14_17 molecular association, regulation DNA(DISRUPTS) 10753971 1 0 0 +BUB1B BUB1B EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, Other; Protein kinase, Ser/Thr (non-receptor); Tumor suppressor O60566 701 15q15.1 human S676-p 767909 LSPIIEDsREATHSS molecular association, regulation; phosphorylation cell cycle regulation; cytoskeletal reorganization PPP2R5A(INDUCES); PPP2CA(INDUCES) 17785528; 20016069; 23079597; 23345399; 27568981; 33207204 9 4 0 T680 is independent of attachment status and may correlate with lack of interkinetochore tension.; regulates KNL1 phosphorylation; regulates chromosome congression; kinetochore-microtubule stability and lack of tension ; chromosome segregation during mitosis and mitotic progression; spindle activation checkpoint (SAC); kinetochore-microtubule attachment +RAPH1 RAPH1 Adaptor/scaffold; Motility/polarity/chemotaxis Q70E73 65059 2q33.2 human Y481-p 54363503 QIQKKSQyIKYLCCD PH molecular association, regulation cell motility, induced 26996666 1 0 0 Lpd-Scar/WAVE interaction is positively regulated by c-Abl and c-Src, breast cancer cell invasion +Rbm20 RBM20 E9PT37 309544 1q55 rat S640-p 31086439 PERPRSRsPMSRSLS RNA splicing, altered 36140694 2 3 0 +Syt7 SYT7 Membrane protein, integral Q62747 59267 1q43 rat S103-p 4758666 RRTEPRSsVSDLVNS exocytosis, induced 26216970 1 1 0 glucose-stimulated insulin secretion, insulin-granule exocytosis +MAP2 MAP2 Cytoskeletal; Motility/polarity/chemotaxis P11137 4133 2q34 human Y67-p 454429 EHGSQGTySNTKENG molecular association, regulation GRB2(INDUCES) 15536091 2 0 1 +PDE4B PDE4B iso2 EC 3.1.4.53; Nucleotide Metabolism - purine; Phosphodiesterase Q07343-2 5142 1p31.3 human S487-p 471380 YQSMIPQsPSPPLDE enzymatic activity, induced 11030732 1 5 0 decreases levels of cAMP +FOXO4 FOXO4 DNA-binding; Oncoprotein; Transcription factor P98177 4303 Xq13.1 human S230-p 471960 PEGATPTsPVGHFAK carcinogenesis, altered; transcription, altered 20959475 1 9 5 +GLE1 GLE1 Karyopherin; Nuclear export Q53GS7 2733 9q34.11 human S92-p 50831365 VPKSPDAsSAFSPAS molecular association, regulation GLE1(INDUCES) 30429220 1 2 0 self-association stress granules' assembly and disassembly, DDX3-ATPase activity inhibited +tao2 TAO2 iso2 Apoptosis; EC 2.7.11.1; KINASE; Kinase, protein; Membrane protein, integral; Membrane protein, multi-pass; Protein kinase, STE; Protein kinase, Ser/Thr (non-receptor) Q9JLS3-2 64666 1q36-q37 rat S1038-p 1308925 AAVPGPLsRSTSVAS intracellular localization endocytosis, altered 17988630 1 0 0 +ATRIP ATRIP Cell cycle regulation; DNA repair, damage; DNA-binding Q8WXE1 84126 3p21.31 human S72-p 454389 TLASQALsQCPAAAR intracellular localization 15451423 1 0 0 +Arhgdia RhoGDI alpha Apoptosis; Cell adhesion; Cell development/differentiation; G protein regulator, misc.; Motility/polarity/chemotaxis Q99PT1 192662 11|11 E2 mouse S96-p 486318 DLTGDLEsFKKQSFV Rho_GDI activity, induced; molecular association, regulation RHOG(DISRUPTS); GIPC1(DISRUPTS) 19581409 3 0 0 ternary complex with syndecan 4 +DDX17 DDX17 iso3 EC 3.6.4.13; Helicase; Nuclear receptor co-regulator; Nucleolus; RNA processing; RNA-binding; Spliceosome; Transcription, coactivator/corepressor Q92841-3 10521 22q13.1 human K50-sm 12726300 WDLSELPkFEKNFYV protein stabilization; molecular association, regulation transcription, inhibited HDAC1(INDUCES) 19995069 1 2 0 estrogen receptor and p53 transcription +HNRNPK hnRNP K RNA splicing; RNA-binding; Spliceosome P61978 3190 9q21.32 human Y72-p 455999 IKALRTDyNASVSVP KH_1 translation, altered 12052863 3 6 0 based on Y72/225/230/234/236/380A mutant +Etv4 ETV4 DNA-binding P28322 18612 11 D|11 65.48 cM mouse K302-ac 26373305 VMGYGYEkSLRPFPD ETS_PEA3_N sumoylation transcription, induced 21543453 1 1 0 acetylated sites inhibits sumoylation reciprocally +Elavl1 HuR RNA-binding P70372 15568 8 A1.1|8 2.0 cM mouse S221-p 478357 QAQRFRFsPMGVDHM molecular association, regulation; intracellular localization transcription, induced Exportin-1(INDUCES); TNFSF13(INDUCES); ANP32A(INDUCES) RNA(INDUCES) 30016500 11 0 0 +STAT2 STAT2 DNA-binding; Transcription factor P52630 6773 12q13.3 human T404-p 1869973803 IWDFGYLtLVEQRSG STAT_bind protein stabilization; molecular association, regulation; intracellular localization; protein conformation; phosphorylation carcinogenesis, induced; transcription, induced; transcription, inhibited; signaling pathway regulation IRF9(INDUCES); STAT1(DISRUPTS); STING(INDUCES) 32759968; 37036972 2 1 0 inhibits phosphorylation of STING and IRF3, inhibits nuclear translocation of IRF3, thus inhibiting the STING?IRF3 pathway; regulation of antiviral defense mechanism; IFN-1 signaling +ZC3HC1 NIPA Cell cycle regulation; Ubiquitin conjugating system Q86WB0 51530 7q32.2 human T387-p 3204981 RSMGTGDtPGLEVPS molecular association, regulation; intracellular localization cell growth, induced NPM-ALK(DISRUPTS) 31434245 1 18 5 +PNKD PNKD iso2 EC 3.-.-.-; Hydrolase Q8N490-2 25953 2q35 human S46-p 35486502 RALQSHSsPEGKEEP molecular association, regulation carcinogenesis, induced ERK1(INDUCES); MEK1(INDUCES) 25066297 1 1 0 activation of MEK/ERK signaling pathway +SLC39A4 SLC39A4 Membrane protein, integral; Membrane protein, multi-pass; Transporter; Transporter, SLC family Q6P5W5 55630 8q24.3 human K463-ub 1877047302 PSELRQPkPPHEGSR Zip protein degradation 32348750 1 0 0 zinc-induced degradation, but not zinc-dependent endocytosis +Ppp1ca PPP1CA EC 3.1.3.16; Nucleolus; PHOSPHATASE; Protein phosphatase, Ser/Thr (non-receptor) P62138 24668 1q43 rat T320-p 448686 NPGGRPItPPRNSAK enzymatic activity, inhibited 24189275 24 43 98 LTD (long-term depression) induction +SQSTM1 SQSTM1 Autophagy; Nuclear receptor co-regulator; Ubiquitin conjugating system Q13501 8878 5q35.3 human S272-p 454787 RSRLTPVsPESSSTE protein degradation; molecular association, regulation; ubiquitination; intracellular localization cell cycle regulation; carcinogenesis, induced; carcinogenesis, altered; autophagy, inhibited; signaling pathway regulation mTOR(INDUCES); LC3B(DISRUPTS); Raptor(INDUCES); TRAF6(INDUCES) 20974803; 26279575; 35840557 9 80 278 +Csf1r CSFR EC 2.7.10.1; KINASE; Kinase, protein; Membrane protein, integral; Oncoprotein; Protein kinase, TK; Protein kinase, tyrosine (receptor) P09581 12978 18 E1|18 34.41 cM mouse Y921-p 455145 LERRDQDyANLPSSG molecular association, regulation cytoskeletal reorganization; cell growth, altered GRB2(INDUCES) 9380408 3 1 1 +Stat3 STAT3 DNA-binding; Motility/polarity/chemotaxis; Nuclear receptor co-regulator; Transcription factor P42227 20848 11 D|11 63.82 cM mouse K383-ac 36313373 AALRGSRkFNILGTN STAT_bind molecular association, regulation transcription, induced; signaling pathway regulation NFkB-p65(INDUCES) 28637784 1 1 2 signaling to improve mitochondrial fusion and function; K383 may induce stronger binding, enhanced OPA1 expression +CSNK1E CK1E EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, CK1; Protein kinase, Ser/Thr (non-receptor) P49674 1454 22q13.1 human T44-p 14694702 IKLECVKtKHPQLHI Pkinase enzymatic activity, induced 20507565 1 0 0 +GCK GK Carbohydrate Metabolism - amino sugar and nucleotide sugar; Carbohydrate Metabolism - galactose; Carbohydrate Metabolism - glycolysis and gluconeogenesis; Carbohydrate Metabolism - starch and sucrose; EC 2.7.1.2; Kinase, other; Mitochondrial P35557 2645 7p13 human K346-sm 27581515 ESDTGDRkQIYNILS Hexokinase_2 protein stabilization; enzymatic activity, induced 23297408 1 1 0 +Ppp1r12a MYPT1 Motility/polarity/chemotaxis; PHOSPHATASE; Protein phosphatase, regulatory subunit Q9DBR7 17931 10 D1|10 56.33 cM mouse T852-p 452075 PREKRRStGVSFWTQ enzymatic activity, inhibited 30377223 44 2 17 +MVB12A FAM125A Adaptor/scaffold Q96EY5 93343 19p13.11 human S232-p 483399 RFEGKSCsPLAFSAF DUF2464 protein processing 18005716 1 8 0 inhibition of HIV-1 release and infectivity +PPARD PPAR-delta DNA-binding; Nuclear receptor Q03181 5467 6p21.31 human Y108-p 1868968410 TIRMKLEyEKCERSC zf-C4 molecular association, regulation carcinogenesis, induced; cell growth, induced; autophagy, inhibited LC3B(INDUCES) 32439863 1 1 0 +SEC63 SEC63 Endoplasmic reticulum; Membrane protein, integral; Membrane protein, multi-pass Q9UGP8 11231 6q21 human S576-p 27440600 VSDKGSDsEEEETNR molecular association, regulation SEC62(INDUCES) 23287549 1 1 0 +Mavs MAVS Adaptor/scaffold; Membrane protein, integral Q8VCF0 228607 2|2 F1 mouse S328-p 143281202 TAPSKLPsNSVYAGT transcription, induced 28725479 1 1 0 +Klhl3 KLHL3 Actin-binding; Cytoskeletal E0CZ16 100503085 13|13 B1 mouse S433-p 36440206 PMNTRRSsVGVGVVE Kelch_1 activity, induced; protein stabilization; phosphorylation 30914436 6 2 0 induces WNK stability, SPAK/OSR1 phosphorylation subsequently increasing NCC phosphorylation and activity +CREB1 CREB DNA-binding; Transcription factor P16220 1385 2q33.3 human S94-p 451807 QISTIAEsEDSQESV molecular association, regulation; phosphorylation CBP(INDUCES) 17209043 8 2 1 mutation to alanine decreases S121 phosphorylation in cells treated with ionizing radiation +LCP2 SLP76 Adaptor/scaffold Q13094 3937 5q35.1 human Y113-p 448218 SSFEEDDyESPNDDQ molecular association, regulation; phosphorylation cytoskeletal reorganization; transcription, induced; signaling pathway regulation NCK1(INDUCES); ITK(INDUCES); PIK3R1(INDUCES); VAV1(INDUCES) 11046020; 12817019; 15388330; 17148460; 21725281; 22534133; 22786724; 23901140 17 0 0 transcriptional activity of NFAT and AP-1; regulates NK cell activation +JAM3 JAM3 Cell adhesion; Membrane protein, integral Q9BX67 83700 11q25 human S281-p 15404111 NNKQDGEsYKNPGKP intracellular localization 28196865 1 0 19 cell-cell contact region, S-palmitoylation of JAM3 is independent of JAM3 phosphorylation on Ser281 +CDT1 CDT1 DNA replication; DNA-binding; Motility/polarity/chemotaxis; Oncoprotein Q9H211 81620 16q24.3 human T406-p 21440503 LPATPPAtPPAASPS protein stabilization; molecular association, regulation; activity, inhibited; phosphorylation RAMP(DISRUPTS); MCM2(DISRUPTS) 21930785; 32841231 2 1 1 inhibits Chk1 phosphorylation +Fhl1 FHL1 iso2 Cell development/differentiation P97447-2 14199 X|X A6 mouse K171-sm 3278910 KCNKGLVkAPVWWPM transcription, induced; signaling pathway regulation 17509614 1 0 0 induces Notch signaling pathway +ESR1 ER-alpha DNA-binding; Nuclear receptor; Transcription factor P03372 2099 6q25.1-q25.2 human S305-p 448805 IKRSKKNsLALSLTA activity, induced; protein stabilization; molecular association, regulation; acetylation; intracellular localization; protein conformation; phosphorylation carcinogenesis, induced; carcinogenesis, altered; cell growth, induced; transcription, induced; transcription, altered; cell growth, altered AKAP13(INDUCES); NRIF3(INDUCES); ER-alpha(INDUCES) 12374744; 15193262; 15604293; 16452229; 17068199; 17627277; 18521086; 20101208; 20179234; 24166501; 24449872; 26272591; 26554417 16 0 0 ER-alpha-dependent transcription +NR1I2 PXR DNA-binding; Nuclear receptor O75469 8856 3q13.33 human S8-p 9730705 MEVRPKEsWNHADFV molecular association, regulation transcription, altered RXRA(DISRUPTS) 19617467 1 0 0 inhibits transcription +EGFR EGFR EC 2.7.10.1; KINASE; Kinase, protein; Membrane protein, integral; Oncoprotein; Protein kinase, TK; Protein kinase, tyrosine (receptor) P00533 1956 7p11.2 human S991-p 455701 DERMHLPsPTDSNFY molecular association, regulation; receptor internalization, altered; phosphorylation ubiquitin(INDUCES); CBL(INDUCES) 19531499 2 34 8 +DDR1 DDR1 EC 2.7.10.1; KINASE; Kinase, protein; Membrane protein, integral; Protein kinase, TK; Protein kinase, tyrosine (receptor) Q08345 780 6p21.33 human Y740-p 458377 AQGPTISyPMLLHVA PK_Tyr_Ser-Thr molecular association, regulation SHP-2(INDUCES); NCK2(INDUCES) 16337946 1 0 0 +SRC Src EC 2.7.10.2; KINASE; Kinase, protein; Oncoprotein; Protein kinase, TK; Protein kinase, tyrosine (non-receptor) P12931 6714 20q11.23 human S70-p 2192576 LFGGFNSsDTVTSPQ receptor internalization, induced; enzymatic activity, induced transcription, induced 27169346 1 2 0 ISO induced EGFR internalization, ADRB2 mediated EGFR transactivation +NCAPG NCAPG Cell cycle regulation Q9BPX3 64151 4p15.31 human T332-p 5014904 LIPVETLtPEIALYW molecular association, regulation; intracellular localization DNA(INDUCES) 18977199 1 0 0 regulates NCAPG localization with chromosomal DNA in mitotic cells +INSR INSR iso2 EC 2.7.10.1; KINASE; Kinase, protein; Membrane protein, integral; Protein kinase, TK; Protein kinase, tyrosine (receptor) P06213-2 3643 19p13.2 human S989-p 449888 SSNPEYLsASDVFPC activity, induced 1656240 1 0 0 mutation of site impairs insulin stimulation of PI3K activity. +PPARG PPAR-gamma iso2 DNA-binding; Nuclear receptor; Transcription factor P37231-2 5468 3p25.2 human Y74-p 9256871 YDLKLQEyQSAIKVE PPARgamma_N protein degradation; molecular association, regulation; ubiquitination carcinogenesis, induced; cell growth, induced; apoptosis, inhibited; signaling pathway regulation MDM2(INDUCES) 26718225 2 0 1 Y74 mutant inhibits EGFR/NFkB signaling-mediated gene expression +ADRB2 ADRB2 GPCR, family 1; Membrane protein, integral; Membrane protein, multi-pass; Receptor, GPCR P07550 154 5q32 human Y326-p 451497 SGFNPLIyCRSPDFR 7tm_1; TM receptor internalization, induced 9145918 3 0 0 sequestration +DGCR8 DGCR8 Nucleolus; RNA processing; RNA-binding Q8WYQ5 54487 22q11.21 human S434-p 27447299 VEVCKDEsVDLEEFR protein stabilization 24239349 1 5 0 +F2R PAR1 Cell development/differentiation; GPCR, family 1; Membrane protein, integral; Membrane protein, multi-pass; Receptor, GPCR P25116 2149 5q13.3 human S391-p 3627501 SILCCKEsSDPSSYN receptor desensitization, altered 10413505 1 0 0 receptor shutoff (not internalization) +STAT1 STAT1 DNA-binding; Transcription factor P42224 6772 2q32.2 human K511-ub 12109287 WQFSSVTkRGLNVDQ ubiquitination IFNAR2(DISRUPTS) 32123171 1 2 4 linear ubiquitination of K511 and K652 and inhibits interaction with INFAR2, INF-I stimulation removes STAT1 linear ubiquitination, viruses upregulate HOIP and STAT1 linear ubiquitination +Slc14a2 SLC14A2 Membrane protein, integral; Membrane protein, multi-pass; Transporter; Transporter, SLC family Q62668 54302 18q12.3 rat S499-p 2813500 WSSIRRRsKVFGKSE activity, induced; molecular association, regulation; intracellular localization SNAPIN(INDUCES) 18495802; 20457831; 25377918 6 0 0 apical plasma membrane accumulation +RIPK3 RIPK3 EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, Ser/Thr (non-receptor); Protein kinase, TKL Q9Y572 11035 14q12 human T224-p 50788489 GREVELPtEPSLVYE Pkinase molecular association, regulation MLKL(INDUCES) 35739084 1 3 0 +PFKFB2 PFKFB2 Carbohydrate Metabolism - fructose and mannose; EC 2.7.1.105; EC 3.1.3.46; Kinase, other; Motility/polarity/chemotaxis; Phosphatase (non-protein) O60825 5208 1q32.1 human S32-p 23003811 EKKCSWAsYMTNSPT 6PF2K molecular association, regulation; enzymatic activity, inhibited; intracellular localization transcription, altered FBPase 2(INDUCES) 22214556; 24566088; 24634222 3 0 0 +PTK2B Pyk2 EC 2.7.10.2; KINASE; Kinase, protein; Nuclear receptor co-regulator; Protein kinase, TK; Protein kinase, tyrosine (non-receptor) Q14289 2185 8p21.2 human Y881-p 447958 DRTDDLVyLNVMELV Focal_AT molecular association, regulation GRB2(INDUCES) 23612968 17 0 1 Grb2 recruitment to SHPS1 +Mecp2 MECP2 Transcription, coactivator/corepressor Q9Z2D6 17257 X A7.3|X 37.63 cM mouse S164-p 481659 FTVTGRGsPSRREQK molecular association, regulation; intracellular localization cell differentiation, altered DNA(DISRUPTS) 27323888 1 2 0 accumulation at heterochromatic foci, P-S164 MeCP2 shows altered nucleosome binding, neuronal dendritic branching and nuclear size +Scn10a SCN10A Channel, sodium; Membrane protein, integral; Membrane protein, multi-pass Q62968 rat S551-p 2482300 QTGPLPRsPLPQSPN activity, induced 18354022 1 0 0 increases SCN10A sodium channel current density +Hoxa9 HOXA9 DNA-binding; Oncoprotein P09631 15405 6 B3|6 25.4 cM mouse S204-p 2906100 ANWLHARsTRKKRCP molecular association, regulation cell differentiation, altered DNA(DISRUPTS) 15082777 1 0 0 +HMCN1 HMCN1 Cell adhesion; Extracellular matrix; Secreted; Secreted, signal peptide Q96RW7 83872 1q25.3-q31.1 human K266-ub 52485008 EIRNPLGkLIKKGFG protein degradation 26676607 0 1 0 +Gabrg2 GABRG2 Channel, chloride; Channel, ligand-gated; Membrane protein, integral; Membrane protein, multi-pass; Transporter; Transporter, ion channel Q6PW52 29709 10q21 rat Y413-p 455818 ERDEEYGyECLDGKD Neur_chan_memb molecular association, regulation; receptor internalization, inhibited neural plasticity; endocytosis, inhibited Src(INDUCES); AP-2 alpha(DISRUPTS) 11640929; 18305175 7 0 0 +Vim Vimentin Cytoskeletal; Motility/polarity/chemotaxis P20152 22352 2 A1|2 10.04 cM mouse S459-p 470128 GQVINETsQHHDDLE cytoskeletal reorganization; endocytosis, inhibited 24196446 5 52 37 required for the inhibition of endocytotic vesicle fusion in mitosis, integrin trafficing toward the clevage furrow +ADD1 ADD1 Cytoskeletal; Motility/polarity/chemotaxis P35611 118 4p16.3 human S355-p 456832 KYKAKSRsPGSPVGE molecular association, regulation cytoskeletal reorganization MYO10(INDUCES) 24379415 2 32 4 association with mitotic spindles +Slc9a1 NHE1 Membrane protein, integral; Membrane protein, multi-pass; Motility/polarity/chemotaxis; Transporter; Transporter, SLC family P26431 24782 5q36 rat S652-p 3880766 KTRQRLRsYNRHTLV NEXCaM_BD activity, induced cytoskeletal reorganization; cell growth, altered 19622752 4 2 6 +CDKN1A p21Cip1 Cell cycle regulation; Inhibitor P38936 1026 6p21.2 human T57-p 451222 NFDFVTEtPLEGDFA CDI protein degradation; molecular association, regulation; protein stabilization; ubiquitination; intracellular localization; phosphorylation cell cycle regulation; apoptosis, induced CDK4(DISRUPTS) 11779850; 19364816; 19822666; 23737759; 23745637 8 0 0 +PKD2L1 PKD2L1 Channel, cation; Membrane protein, integral; Membrane protein, multi-pass; Motility/polarity/chemotaxis Q9P0L9 9033 10q24.31 human S686-p 394791407 LGRSIVSsPQGKSGP activity, induced 29230552 1 0 0 regulates the channel activity +CDC25A CDC25A EC 3.1.3.48; Motility/polarity/chemotaxis; PHOSPHATASE; Protein phosphatase, dual-specificity P30304 993 3p21.31 human S293-p 449128 GSTKRRKsMSGASPK M-inducer_phosp protein degradation 12676583 2 1 1 +Pdha1 PDHA1 Amino Acid Metabolism - valine, leucine and isoleucine biosynthesis; Carbohydrate Metabolism - butanoate; Carbohydrate Metabolism - citrate (TCA) cycle; Carbohydrate Metabolism - glycolysis and gluconeogenesis; Carbohydrate Metabolism - pyruvate; EC 1.2.4.1; Mitochondrial; Oxidoreductase P35486 18597 X F4|X 73.95 cM mouse S232-p 448257 NRYGMGTsVERAAAS E1_dh enzymatic activity, inhibited cell cycle regulation; signaling pathway regulation 21775648; 28632902; 30726738; 34988082; 36211560 45 79 7 +AR AR DNA-binding; Nuclear receptor; Transcription factor P10275 367 Xq12 human R407-p 23303205 AAAAAQCrYGDLASL Androgen_recep molecular association, regulation; protein conformation transcription, inhibited 22334658 1 0 0 AR N/C interaction-dependent transcriptional activity +CPEB3 CPEB3 RNA-binding Q8NE35 22849 10q23.32 human K46-sm 1877467600 PLSSETPkPEENSAV molecular association, regulation ACTB(DISRUPTS) 32848053 1 0 0 SUMOylation of CPEB3 is a potential inhibitor for the CPEB3/F-actin interaction +PSMC3 RPT5 Nuclear receptor co-regulator; Proteasome complex; Transcription, coactivator/corepressor P17980 5702 11p11.2 human Y381-p 55371058 NVSPDVNyEELARCT AAA_lid_3 protein stabilization 28435470 1 2 0 +RRN3 TIF1A Nucleolus; Transcription initiation complex Q9NYV6 54700 16p13.11 human S172-p 470002 GDVDVSDsDDEDDNL RRN3 activity, induced; protein stabilization; molecular association, regulation; intracellular localization cell cycle regulation; chromatin organization, altered; transcription, induced POLM(DISRUPTS); TWISTNB(DISRUPTS) DNA(INDUCES) 18559419; 24297901; 27257073 3 24 2 rDNA transcription; rRNA synthesis induced +Dlg4 PSD-95 Adaptor/scaffold Q62108 13385 11|11 B3 mouse K558-ub 3933139 LLSEFPDkFGSCVPH Guanylate_kin molecular association, regulation neural plasticity; cytoskeletal reorganization GKAP1(INDUCES); AKAP1(INDUCES); SPAAR(INDUCES) 28973854 1 1 13 K63-polyUb regulates these interactions, regulate postsynaptic scaffolding and synapse organization +TTK TTK Cancer Testis Antigen (CTA); EC 2.7.12.1; KINASE; Kinase, protein; Protein kinase, Other; Protein kinase, dual-specificity (non-receptor) P33981 7272 6q14.1 human S15-p 13194900 GRELTIDsIMNKVRD intracellular localization 18923149; 36395767 5 1 2 +KNSTRN TRAF4AF1 Q9Y448 90417 15q15.1 human T294-p 1876350206 VRFLEQQtLCNNQVN cell cycle regulation; carcinogenesis, induced; cell motility, induced; transcription, altered 35201967 1 0 0 +EIF2S1 eIF2-alpha RNA-binding; Translation; Translation initiation P05198 1965 14q23.3 human S52-p 447635 MILLSELsRRRIRSI S1 activity, induced; molecular association, regulation; activity, inhibited carcinogenesis, induced; carcinogenesis, inhibited; cell growth, inhibited; apoptosis, induced; transcription, induced; translation, altered; autophagy, induced; RNA splicing, induced; cell growth, induced; apoptosis, inhibited; translation, induced; cell growth, altered; translation, inhibited eIF2-beta(INDUCES); PERK(INDUCES); CELF1(INDUCES) 11432733; 12370288; 16288713; 16717090; 16952278; 17553788; 17998206; 19934253; 20660158; 25660019; 25759478; 26100016; 27409837; 28683312; 32054729; 33705388; 34244887; 34380029; 34426706; 34615996; 35035775; 35331268; 35354045; 35378132; 36226539; 36460969; 36480552; 36898579; 7641700 132 2 0 +BCHE BCHE EC 3.1.1.8; Hydrolase; Nuclear envelope; Secreted; Secreted, signal peptide P06276 590 3q26.1 human S226-p 25157201 SVTLFGEsAGAASVS COesterase enzymatic activity, inhibited 22444575 0 1 0 +RACK1 RACK1 Adaptor/scaffold; G protein; G protein, heterotrimeric; G protein, heterotrimeric beta; Motility/polarity/chemotaxis; Nuclear receptor co-regulator P63244 10399 5q35.3 human T39-p 56567301 LSASRDKtIIMWKLT WD40 molecular association, regulation autophagy, induced ATG5(INDUCES) 27325703 1 1 0 +Vav1 VAV1 GEF; GEF, Rac/Rho; Motility/polarity/chemotaxis; Oncoprotein P27870 22324 17 D|17 29.76 cM mouse Y174-p 447866 EAEGDEIyEDLMRLE activity, induced; protein conformation; activity, inhibited cytoskeletal reorganization; transcription, altered; cell growth, altered 10669745; 20141838; 34617326 22 2 0 +THOC5 FMIP Cell development/differentiation; RNA splicing; Spliceosome Q13769 8563 22q12.2 human S6-p 453433 __MSSESsKKRKPKV intracellular localization 15221008 1 0 0 +Rb1 Rb Nuclear receptor co-regulator; Oncoprotein; Transcription, coactivator/corepressor; Tumor suppressor P13405 19645 14 38.73 cM|14 D3 mouse S800-p 447980 PGGNIYIsPLKSPYK Rb_C molecular association, regulation; protein conformation; phosphorylation cell cycle regulation; carcinogenesis, induced; transcription, induced; transcription, altered; cell growth, induced; chromatin organization, altered; apoptosis, inhibited; DNA repair, inhibited; transcription, inhibited E2F1(DISRUPTS); SUV420H1(DISRUPTS); SUV420H2(DISRUPTS) 10207050; 1565466; 32086342; 33826903; 35023164; 35947949; 9671466 102 45 112 transcriptional downregulation of the E2F-1, E2F-2, dihydrofolate reductase, thymidine kinase, c-myc, proliferating-cell nuclear antigen, p107, and p21/Cip1 genes +Notch1 Notch 1 Membrane protein, integral; Motility/polarity/chemotaxis; Oncoprotein; Receptor, misc.; Transcription factor Q01705 18128 2 A3|2 18.91 cM mouse K2147-ac 18899504 KSATQGKkARKPSTK protein stabilization; ubiquitination 21499261 2 1 0 +Ksr1 KSR KINASE; Kinase, protein; Protein kinase, Ser/Thr (non-receptor); Protein kinase, TKL Q61097 16706 11 B5|11 46.74 cM mouse S392-p 449297 ARLRRTEsVPSDINN protein degradation; molecular association, regulation; intracellular localization cell cycle regulation; cell growth, altered 14-3-3 beta(INDUCES); 14-3-3 gamma(INDUCES) 11741534; 11741955; 12105213; 15371409; 28003362; 9858547 8 48 75 +Eif2ak3 PERK EC 2.7.11.1; KINASE; Kinase, protein; Membrane protein, integral; Protein kinase, Other; Protein kinase, Ser/Thr (non-receptor); Translation Q9Z2B5 13666 6|6 C1 mouse Y615-p 1256400 NKVDDCNyAIKRIRL Pkinase enzymatic activity, induced translation, altered 17998206 4 1 0 regulates translation through the phosphorylation of eIF2A at S51 +HSF1 HSF1 DNA-binding; Transcription factor Q00613 3297 8q24.3 human T323-p 4169776 GRPSSVDtLLSPTAL Vert_HS_TF transcription, inhibited 25963659 2 8 1 under non-stressed conditions, upon heat shock S to A mutant showed 60% higher luciferase activity +HDAC1 HDAC1 DEACETYLASE; Deacetylase; EC 3.5.1.98; Hydrolase; Nuclear receptor co-regulator Q13547 3065 1p35.2-p35.1 human K441-ac 4219804 SSNFKKAkRVKTEDE enzymatic activity, inhibited transcription, inhibited 16762839 1 0 0 +Crtc2 TORC2 Transcription, coactivator/corepressor Q3U182 74343 3|3 F1 mouse S307-p 454633 PSLSGGNsTTNLTHT TORC_M intracellular localization transcription, induced 20551288; 33127851 2 1 0 +HMGB1 HMGB1 DNA repair, damage; Nuclear receptor co-regulator P09429 3146 13q12.3 human S42-p 9484300 SVNFSEFsKKCSERW HMG_box_2 intracellular localization cell motility, altered 19506549; 23782844 3 0 2 increases tumor cell invasiveness +Hspa1a HSP70 Chaperone; Heat shock protein; Motility/polarity/chemotaxis Q61696 193740 17 B1|17 18.51 cM mouse R447-me 1877047300 IQVYEGErAMTRDNN HSP70 protein stabilization carcinogenesis, induced; cell growth, induced; apoptosis, inhibited RNA(INDUCES) 32699135 1 1 0 binding and stabilization of BCL2 mRNA +AQP4 AQP4 Channel, misc.; Membrane protein, integral; Membrane protein, multi-pass; Transporter; Transporter, aquaporin family P55087 361 18q11.2 human S276-p 465556 AAQQTKGsYMEVEDN intracellular localization 26013827 2 6 0 translocation to cell surface +ABCC8 ABCC8 Membrane protein, integral; Membrane protein, multi-pass; Transporter; Transporter, ABC family Q09427 hamster S1447-p 22634903 LDPEKKCsDSTLWEA ABC_tran activity, induced 12198249 1 0 0 channel closure +ETS2 Ets-2 DNA-binding; Oncoprotein; Transcription factor P15036 2114 21q22.2 human S225-p 30320501 LDSMCPAsTPSVLSS protein degradation 24218572; 26871468 2 1 0 CDK10 mediated degradation +NR3C1 GR DNA-binding; Mitochondrial; Nuclear receptor; Transcription factor P04150 2908 5q31.3 human S211-p 447968 PGKETNEsPWRSDLL GCR activity, induced; molecular association, regulation; protein stabilization; intracellular localization; protein conformation; activity, inhibited cell cycle regulation; apoptosis, induced; transcription, induced; transcription, altered; transcription, inhibited GRIP1(INDUCES) 15817653; 17440046; 19841061; 20047289; 21829454; 24024586; 25847991; 28582465; 33235235; 35409338; 36103837 51 5 0 +Tp53 p53 Activator; DNA-binding; Motility/polarity/chemotaxis; Nuclear receptor co-regulator; Transcription factor; Tumor suppressor P02340 22059 11 B3|11 42.83 cM mouse K117-ac 474514 FLQSGTAkSVMCTYS P53 cell cycle regulation; carcinogenesis, inhibited; cell growth, inhibited; apoptosis, induced; transcription, induced 25858503; 31004086; 33303641; 33789902; 35534985 44 8 0 HDAC6 ablation induces senescence p21 expression and inhibits cell growth, HDAC6 ablation inhibits HC proliferation after two-thirds partial hepatectomy (PHx); recruit p300, CBP, and TIP60 onto PD-1 promoter, p53-mediated PD-1 transcription; increase in C-terminal methylation (K370, K372 dimethylation) and K117 acetylation leads to induction of pro-apoptotic p53 target genes Bax, Puma, Noxa TrailR2 in response to IR ; senescence, ferroptosis, failed to develop early-onset tumors +Hnf4a HNF4 alpha DNA-binding; Nuclear receptor; Transcription factor P49698 15378 2 H3|2 84.32 cM mouse S262-p 63076100 CPELAEMsRVSIRIL Hormone_recep molecular association, regulation SSU72(INDUCES) 34616001 2 1 0 +FBXO46 FBX46 UBIQUITIN LIGASE; Ubiquitin conjugating system; Ubiquitin ligase Q6PJ61 23403 19q13.32 human S21-p 1261736702 PRPFGTYsQNQPRPP protein degradation 30171069 1 0 0 +KLF2 KLF2 C2H2-type zinc finger protein; DNA-binding Q9Y5W3 10365 19p13.11 human T173-p 4728135 RPPPPPDtPPLSPDG protein degradation; ubiquitination carcinogenesis, induced; cell motility, induced; cell growth, induced 33758320 2 8 21 +Ctnnd1 CTNND1 Actin-binding; Adaptor/scaffold; Cell adhesion; G protein regulator, misc.; Motility/polarity/chemotaxis P30999 12388 2 D|2 49.45 cM mouse T310-p 450457 GTARRTGtPSDPRRR molecular association, regulation cell adhesion, inhibited 26175155; 26845024 10 7 28 310A and 268A mutants showed clumping, overall phosphorylation regulates activity; decreased homophilic binding affinity of E-cadherin +Cgas cGAS EC 2.7.7.86 Q8C6L5 214763 9|9 E1 mouse K372-sm 62952702 LSFSHTEkYILNNHG Mab-21 enzymatic activity, inhibited transcription, inhibited; signaling pathway regulation DNA(DISRUPTS) 28095500 1 0 0 regulation of STING signaling pathway +COIL coilin Oxidoreductase P38432 8161 17q22 human T122-p 459728 QLEEGEEtEPDCKYS Coilin_N cell growth, inhibited 21991343 1 54 61 Cajal body formation, phosphomutant cell lines show a significant reduction in CB formation compared to wild-type after endogenous coilin knockdown +Crtc2 TORC2 Transcription, coactivator/corepressor Q3U182 74343 3|3 F1 mouse S171-gl 10902816 SALNRTSsDSALHTS TORC_M activity, induced; molecular association, regulation; intracellular localization; phosphorylation 14-3-3 beta(DISRUPTS) 18323454 1 1 0 inhibits phosphorylation of its own site +PSTPIP2 PSTPIP2 Actin-binding Q9H939 9050 18q21.1|tdb7990 human Y333-p 449699 VDDYSLLyQ______ molecular association, regulation SHIP(INDUCES) 26304991 1 1 2 +WDHD1 WDHD1 DNA-binding O75717 11169 14q22.2-q22.3 human T826-p 458395 KAAELTAtQVEEEEE molecular association, regulation; intracellular localization; protein conformation; phosphorylation; enzymatic activity, induced carcinogenesis, induced; DNA repair, induced FANCM(INDUCES); FAAP24(INDUCES); claspin(INDUCES) DNA(INDUCES) 26082189; 35867033 2 8 28 +MET Met EC 2.7.10.1; KINASE; Kinase, protein; Membrane protein, integral; Oncoprotein; Protein kinase, TK; Protein kinase, tyrosine (receptor) P08581 4233 7q31.2 human S985-p 450188 PHLDRLVsARSVSPT enzymatic activity, inhibited; intracellular localization cell motility, induced; signaling pathway regulation 23618918; 24634221; 27147579; 8294430 7 1 0 increased intracellular localization, and decreased cell membrane localization ; signaling to induce lamellipodia formation and ROS generation in lung cells; in vitro; Ser985 phosphorylation blocks Tyr1234 phosphorylation of c-Met +NADK2 NADK2 EC 2.7.1.23 Q4G0N4 133686 5p13.2 human S289-p 25746483 ESLSSRAsYYEISVD enzymatic activity, inhibited 26577408 1 0 1 +Ppfia1 liprin alpha 1 Cell adhesion; Motility/polarity/chemotaxis D3ZZ81 293645 1q42 rat T700-p 31873705 PPGSGRStPRRVPHS molecular association, regulation; intracellular localization PSD-95(DISRUPTS) 28760951 1 1 0 regulates synaptic plasticity +E2F1 E2F1 DNA-binding; Transcription factor Q01094 1869 20q11.22 human S235-p 1870773100 TTQLRLLsEDTDSQR E2F_CC-MB protein degradation; enzymatic activity, induced cell cycle regulation; cell growth, inhibited; apoptosis, induced 33110360 1 0 0 induces ?-galactosidase activity +FMR1 FMR1 Nucleolus; RNA-binding; Translation Q06787 2332 Xq27.3 human R544-me 4046000 GGRGQGGrGRGGGFK RNA splicing, altered 16922515 4 0 0 S500 phosphorylation has no affect on methylation; alternatively spliced variant of FMR1 exon 15, reduced methylation by more than 85% +Cask CASK Adaptor/scaffold; EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, CAMK; Protein kinase, Ser/Thr (non-receptor) Q62915 29647 Xq12 rat T724-p 12568401 LPAFKRKtLVLLGAH Guanylate_kin molecular association, regulation transcription, altered TBR1(INDUCES) 20067577 1 0 2 CASK-Tbr1 complex regulates expression of NMDAR2b +Arrb2 ARRB2 Adaptor/scaffold Q91YI4 216869 11 B3|11 42.99 cM mouse K18-ub 6140806 KKSSPNCkLTVYLGK molecular association, regulation mAChR M2(INDUCES); mAChR m1(INDUCES) 19055777 1 0 0 +Slc17a7 SLC17A7 Membrane protein, integral; Membrane protein, multi-pass; Transporter; Transporter, SLC family; Vesicle Q62634 116638 1q22 rat S522-p 4717549 QLAGSDEsEMEDEVE molecular association, regulation AP2A2(INDUCES) 25334008 1 1 0 +CAT Catalase Amino Acid Metabolism - tryptophan; Apoptosis; EC 1.11.1.6; Endoplasmic reticulum; Energy Metabolism - methane; Hydrolase; Mitochondrial; Oxidoreductase P04040 847 11p13 human S167-p 30259808 LFPSFIHsQKRNPQT Catalase protein conformation; enzymatic activity, induced 24211614 1 1 0 phosphorylation necessary for tetramerization +AR AR DNA-binding; Nuclear receptor; Transcription factor P10275 367 Xq12 human S516-p 452166 VSRVPYPsPTCVKSE protein degradation; ubiquitination; intracellular localization cell cycle regulation; cell growth, induced; transcription, induced; transcription, altered 18511414; 21157430; 23321516; 28638477; 29423094 10 3 0 +HSPA5 GRP78 Chaperone; Heat shock protein; KINASE P11021 3309 9q33.3 human K154-ac 13362600 AMVLTKMkETAEAYL HSP70 molecular association, regulation; phosphorylation apoptosis, induced; signaling pathway regulation PERK(DISRUPTS) 20371724 1 2 0 induces phosphorylation of elf2a and activation of eIf2a-ATF4-CHOP pathway +PKN2 PKN2 EC 2.7.11.13; KINASE; Kinase, protein; Protein kinase, AGC; Protein kinase, Ser/Thr (non-receptor) Q16513 5586 1p22.2 human T816-p 447838 GYGDRTStFCGTPEF Pkinase enzymatic activity, induced 10753910; 19723632 4 7 290 +Ep300 p300 ACETYLTRANSFERASE; Acetyltransferase; EC 2.3.1.48; Motility/polarity/chemotaxis; Nuclear receptor co-regulator; Transcription, coactivator/corepressor B2RWS6 328572 15|15 E1 mouse S2312-p 486263 RSPQPVPsPRPQSQP phosphorylation transcription, induced 21498542 2 10 1 induces NFAT phosphorylation +XRCC6 Ku70 DNA repair, damage; DNA-binding; EC 3.6.4.-; EC 4.2.99.-; Helicase; Nuclear receptor co-regulator; RNA-binding P12956 2547 22q13.2 human K282-ac 483055 NLVQKALkPPPIKLY Ku molecular association, regulation DNA repair, inhibited DNA(DISRUPTS) 17545612 1 1 0 +SMURF2 SMURF2 EC 6.3.2.-; EC 6.3.2.19; Ligase; UBIQUITIN LIGASE; Ubiquitin conjugating system; Ubiquitin ligase Q9HAU4 64750 17q23.3-q24.1 human K119-ub 1877715600 YQRLDLCkLGPNDND protein degradation; ubiquitination cell differentiation, induced 31076633 1 1 0 +HMOX1 HMOX1 Cofactor and Vitamin Metabolism - porphyrin and chlorophyll; EC 1.14.99.3; Oxidoreductase P09601 3162 22q12.3 human S188-p 2897404 LYRSRMNsLEMTPAV Heme_oxygenase molecular association, regulation; enzymatic activity, induced BVR(INDUCES); POR(INDUCES) 15581622 1 1 3 +EXOC7 EXOC7 Cytoskeletal Q9UPT5 23265 17q25.1 human S250-p 483909 SSSGVPYsPAIPNKR molecular association, regulation exocytosis, induced; cell motility, induced; cytoskeletal reorganization EXOC4(INDUCES); EXOC8(INDUCES) 22595671 1 25 6 +FLRT1 FLRT1 Cell adhesion; Membrane protein, integral; Motility/polarity/chemotaxis Q9NZU1 23769 11q13.1 human Y671-p 14150101 GGIPDIDySYT____ intracellular localization cell growth, altered 20421966 1 0 0 regulates ERK1/2 activation +GLUL GLUL Amino Acid Metabolism - alanine, aspartate and glutamate; Amino Acid Metabolism - arginine and proline; EC 4.1.1.15; EC 6.3.1.2; Energy Metabolism - nitrogen; Ligase P15104 2752 1q25.3 human K14-ac 33351284 SHLNKGIkQVYMSLP protein degradation; molecular association, regulation; ubiquitination CRBN(INDUCES) 26990986 1 3 0 +Tnfaip1 TNFAIP1 DNA replication; Ubiquitin conjugating system O70479 21927 11 B5|11 46.74 cM mouse S280-p 3195881 SRSQASPsEDEDTFE intracellular localization 33159672 2 11 0 +SREBF2 SREBP-2 DNA-binding; Membrane protein, integral; Membrane protein, multi-pass; Transcription factor Q12772 6721 22q13.2 human K464-sm 2715400 LLDDAKVkDEPDSPP molecular association, regulation transcription, inhibited HDAC3(INDUCES) 12615929; 18403372 2 0 0 +HELLS HELLS Apoptosis; EC 3.6.1.-; EC 3.6.4.-; Helicase Q9NRZ9 3070 10q23.33 human S503-p 9764950 EKETIELsPTGRPKR SNF2-rel_dom molecular association, regulation; methylation carcinogenesis, induced PRMT5(DISRUPTS) 32994405 1 20 0 downregulates methylation of HELLS at R309, promotes stem cell-like properties +DDIT3 DDIT3 Autophagy; DNA-binding; Oncoprotein; Transcription factor P35638 1649 12q13.3 human S31-p 455504 DLQEVLSsDENGGTY activity, inhibited transcription, inhibited 12876286 1 0 0 +MAP2 MAP2 Cytoskeletal; Motility/polarity/chemotaxis P11137 4133 2q34 human S1679-p 456808 NVKSKIGsTDNIKYQ Tubulin-binding molecular association, regulation; intracellular localization cytoskeletal reorganization TUBA1A(INDUCES); ACTB(INDUCES) 11029056 2 7 1 +RBL2 Rb-like 2 Transcription, coactivator/corepressor; Tumor suppressor Q08999 5934 16q12.2 human S639-p 449726 DEICIAGsPLTPRRV molecular association, regulation cell cycle regulation E2F4(DISRUPTS) 11157749; 12006580 4 24 31 +MAD1L1 MAD1L1 Cell cycle regulation; Cytoskeletal Q9Y6D9 8379 7p22.3 human Y634-p 1019903 QEFRKACyTLTGYQI MAD cell cycle regulation 29162720 1 0 0 +KHSRP KHSRP RNA-binding Q92945 8570 19p13.3 human S670-p 482098 GPGAPPGsQPDYSAA DUF1897 activity, induced; molecular association, regulation 21329876 1 1 2 binds to and functions in pri-miRNA processing +P2RY1 P2RY1 GPCR, family 1; Membrane protein, integral; Membrane protein, multi-pass; Receptor, GPCR P47900 5028 3q25.2 human S352-p 1983719 RSEANLQsKSEDMTL receptor internalization, altered 19741005; 21108629 2 2 0 +Klf5 KLF5 C2H2-type zinc finger protein; DNA-binding; Transcription factor Q9Z0Z7 12224 14|14 E2.2 mouse K151-sm 4645802 RPCVTQIkTEPVTIF intracellular localization carcinogenesis, induced; cell growth, induced 18782761 2 0 0 +Syt4 SYT4 Calcium-binding; Membrane protein, integral; Vesicle P50232 64440 18p12 rat S135-p 4706863 ETEKEAVsPESLKSS molecular association, regulation neural plasticity KIF1A(DISRUPTS) 29166604 2 5 0 reduces vesicle mobility after synapse formation; decreased mobility of S135E vesicles is due to decreased binding of phosphorylated Syt4 to Kif1A; actin is specifcally involved in a Syt4 S135 phosphorylation-dependent mechanism of vesicle capture at synapses,increased neuronal activity increases p-JNK at synapses, which captures Syt4 vesicles +Smpd3 SMPD3 EC 3.1.4.12; Lipid Metabolism - sphingolipid; Membrane protein, integral; Phospholipase Q9JJY3 58994 8|8 D3 mouse S289-p 4780074 QRDGDSGsLGSPSAS protein stabilization; enzymatic activity, induced 22074919 1 12 2 +POLB POLB DNA repair, damage; DNA replication; EC 2.7.7.7; Lyase; Transferase P06746 5423 8p11.21 human K72-ac 460603 VGTKIAEkIDEFLAT HHH_8 DNA repair, inhibited 12453427 1 3 0 +ITCH ITCH EC 6.3.2.-; EC 6.3.2.19; Ligase; UBIQUITIN LIGASE; Ubiquitin conjugating system; Ubiquitin ligase Q96J02 83737 20q11.22 human Y420-p 454077 QFNQRFIyGNQDLFA molecular association, regulation JunB(DISRUPTS) 16387660 1 2 108 +RBBP8 CtIP EC 3.1.-.-; Transcription, coactivator/corepressor Q99708 5932 18q11.2 human T859-p 27427901 WEVGFPStQTCMERG SAE2 molecular association, regulation DNA repair, induced; cell growth, induced DNA(INDUCES) 23273981; 31097467 6 1 0 +CAMKK2 CAMKK2 Autophagy; EC 2.7.11.17; KINASE; Kinase, protein; Protein kinase, Other; Protein kinase, Ser/Thr (non-receptor) Q96RR4 10645 12q24.31 human S495-p 469882 KTMIRKRsFGNPFEG molecular association, regulation; enzymatic activity, inhibited Calmodulin(DISRUPTS) 32913128 3 42 35 +Sos1 SOS1 Adaptor/scaffold; GEF; GEF, Ras; Motility/polarity/chemotaxis Q62245 20662 17 E3|17 50.67 cM mouse Y1182-p 34550593 SKAYSPRySISDRTS cell motility, induced; cytoskeletal reorganization 28819285 1 1 3 SOS1 RAC1 GEF activity +TARDBP TDP-43 RNA-binding Q13148 23435 1p36.22 human S379-p 3084615 NSYSGSNsGAAIGWG molecular association, regulation; intracellular localization; phosphorylation RNA splicing, inhibited; RNA stability, inhibited TDP-43(DISRUPTS) 34107054; 35112738 6 2 0 primes phosphorylation at other sites; promotes cytoplasmic aggregation +IRS2 IRS2 Adaptor/scaffold; Motility/polarity/chemotaxis Q9Y4H2 8660 13q34 human Y978-p 463371 QRSPLSDyMNLDFSS molecular association, regulation PIK3C2A(INDUCES) 30459283 1 6 21 +ARRB2 ARRB2 iso2 Adaptor/scaffold P32120-2 281638 cow K295-sm 25350103 LALDGKLkHEDTNLA Arrestin_C molecular association, regulation AP-2 beta(INDUCES) 21118812 2 0 0 GPCR endocytosis induced +KLF5 KLF5 C2H2-type zinc finger protein; DNA-binding; Transcription factor Q13887 688 13q22.1 human R57-m2 1881305500 ELKHAHHrPQAQPAP protein stabilization cell growth, induced 33972717 1 0 0 cell growth and stemness +SMAD4 SMAD4 DNA-binding; Nuclear receptor co-regulator; Transcription, coactivator/corepressor Q13485 4089 18q21.2 human Y301-p 1881244702 MPPHPGHyWPVHNEL molecular association, regulation cell cycle regulation; carcinogenesis, induced; cell growth, induced; transcription, inhibited p300(DISRUPTS); CBP(DISRUPTS); H3(DISRUPTS) 36959211 1 1 0 binding to p300 promotes p300 binding to DNA +NCL NCL DNA-binding; Helicase; Nuclear receptor co-regulator; Nucleolus; RNA-binding P19338 4691 2q37.1 human S28-p 452262 PKEVEEDsEDEEMSE intracellular localization cell cycle regulation; cell growth, induced 25313645 2 45 9 +Kcnc3 Kv3.3 Membrane protein, integral; Membrane protein, multi-pass Q63959 16504 7 B3|7 28.85 cM mouse S3-p 2840509 _____MLsSVCVWSF Potassium_chann activity, inhibited 18539595 1 0 0 +Diaph3 Diaphanous-3 Motility/polarity/chemotaxis Q9Z207 56419 14|14 E1 mouse S1070-p 14572460 KLKDIRQsLSPMSQR activity, induced; molecular association, regulation; intracellular localization; protein conformation transcription, induced; cytoskeletal reorganization Diaphanous-3(DISRUPTS) 21699497 1 14 0 +Top2b TOP2B Cell development/differentiation; DNA-binding; EC 5.99.1.3; Motility/polarity/chemotaxis; Nucleolus; Topoisomerase Q64511 21974 14|14 A2 mouse S1509-p 452750 KIVETINsDSDSEFG DTHCT transcription, inhibited 36206766 1 81 11 +XRCC1 XRCC1 DNA repair, damage P18887 7515 19q13.31 human S421-p 3181474 EASHSGGsGDEAPKL molecular association, regulation PARP1(DISRUPTS) 25477519 1 4 0 +RBM10 RBM10 C2H2-type zinc finger protein; RNA splicing; RNA-binding P98175 8241 Xp11.3 human S89-p 4033099 RRRRHRHsPTGPPGF molecular association, regulation carcinogenesis, induced; RNA splicing, altered; cell growth, induced; RNA stability, induced RNA(INDUCES) 37334492 1 47 31 +NF2 Merlin Cytoskeletal; Motility/polarity/chemotaxis; Tumor suppressor P35240 4771 22q12.2 human K159-ub 21178798 DYDPSVHkRGFLAQE FERM_M molecular association, regulation; intracellular localization LATS1(DISRUPTS) 30918126 1 4 0 K63 kinked +VCL Vinculin Cell adhesion; Cytoskeletal; Motility/polarity/chemotaxis P12003 396422 chicken Y100-p 454004 QMLQADPySVPARDY Vinculin protein conformation cell adhesion, altered 15229287 4 3 53 phosphorylation of this site positively regulates cell spreading +ERRFI1 MIG-6 Inhibitor; Tumor suppressor Q9UJM3 54206 1p36.23 human S256-p 17547330 SHSGPAGsFNKPAIR activity, inhibited 29196224 1 3 0 ine?cient ubiquitination and increased stability of EGFR +MYC Myc DNA-binding; Nucleolus; Oncoprotein; Transcription factor P01106 4609 8q24.21 human K172-sm 40724410 ASYQAARkDSGSPNP Myc_N protein degradation; ubiquitination transcription, inhibited 25895136 1 1 0 +MARCKS MARCKS Actin-binding; Motility/polarity/chemotaxis P12624 613548 cow S162-p 447787 KRFSFKKsFKLSGFS MARCKS exocytosis, induced 22013076 24 30 7 Calcium mobilization, degranulation induced and dissociation of MARCK5 from plasma membrane. +Gabbr1 GABBR1 GPCR, family 3; Membrane protein, integral; Membrane protein, multi-pass; Receptor, GPCR Q9Z0U4 81657 20p12 rat K698-ub 59175200 FTKKEEKkEWRKTLE 7tm_3 receptor recycling, inhibited; protein degradation; intracellular localization 27573246 1 0 0 +NOL3 ARC Apoptosis; Nucleolus O60936 8996 16q22.1 human T149-p 448618 SEAVQSGtPEEPEPE intracellular localization apoptosis, inhibited 26172393 5 6 0 inhibits DOX-induced apoptosis +Ngfr NGFR Membrane protein, integral; Receptor, misc. P07174 24596 10q26 rat Y337-p 454435 LKGDGNLySSLPLTK protein degradation; molecular association, regulation CBL(INDUCES) 15337528 1 1 3 +MAPT Tau iso8 ACETYLTRANSFERASE; Acetyltransferase; Cytoskeletal P10636-8 4137 17q21.31 human S352-p 487459 DFKDRVQsKIGSLDN Tubulin-binding molecular association, regulation 21204788 2 1 0 in vitro microtubule binding +TERF2IP TERF2IP DNA replication Q9NYB0 54386 16q23.1 human S205-p 471278 GDAPVSPsSQKLKRK intracellular localization apoptosis, induced; transcription, induced; transcription, inhibited; signaling pathway regulation 31045573; 31476350 2 6 2 important for NFkB activation by TNF-alpha; endothelial cell senescence and activation; promotes the nuclear export of the TERF2IP-TRF2 complex +ECE1 ECE1 iso3 Cell surface; EC 3.4.24.71; Membrane protein, integral; Protease; Vesicle P42892-3 1889 1p36.12 human S18-p 3053605 DEEDLVDsLSEGDAY protein stabilization; intracellular localization; phosphorylation cell cycle regulation; carcinogenesis, induced; cell growth, induced; cell motility, induced; apoptosis, inhibited; transcription, induced 26543229; 32850305 3 12 1 induces FAK phosphorylation; colon cancer cell invasion. +FH fumarase Carbohydrate Metabolism - citrate (TCA) cycle; EC 4.2.1.2; Lyase; Mitochondrial; Tumor suppressor P07954 2271 1q43 human S75-p 116533304 YGAQTVRsTMNFKIG Lyase_1 molecular association, regulation cell growth, induced; transcription, induced ATF-2(INDUCES) 28628081 1 1 0 +Rps6kb1 p70S6K EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, AGC; Protein kinase, Ser/Thr (non-receptor); Translation Q8BSK8 72508 11|11 C mouse S434-p 448356 SFEPKIRsPRRFIGS molecular association, regulation DEDD(INDUCES) 19106089 28 1 0 Association with DEDD in vitro and in vivo prevents inhibitory phosphorylation by Cdk1 at S434, T444, and S447. +MEF2C MEF2C DNA-binding; Transcription factor Q06413 4208 5q14.3 human K252-ac 12674410 NLGMNNRkPDLRVLI molecular association, regulation cell differentiation, induced; transcription, induced MRF(INDUCES) DNA(INDUCES) 15831463 1 0 0 +Acadl ACADL EC 1.3.8.8; Lipid Metabolism - fatty acid; Mitochondrial; Oxidoreductase P51174 11363 1 C3|1 33.64 cM mouse K42-ac 1194111 RLETPSAkKLTDVGI enzymatic activity, inhibited 20203611 2 3 13 regulation of fatty-acid oxidation +MORC2 MORC2 DNA-binding Q9Y6X9 22880 22q12.2 human K767-ac 11324199 KRGRFVVkEEKKDSN molecular association, regulation cell cycle regulation; DNA repair, induced; transcription, inhibited H3(INDUCES) 32112098 1 2 0 Acetylated MORC2 at K767 binds to H3T11P, downregulation of H3T11P and transcriptional repression of CDK1 and Cyclin B1 +Trim28 TIF1B EC 6.3.2.-; KINASE; Kinase, protein; Ligase; Nuclear receptor co-regulator; Protein kinase, atypical; SUMO LIGASE; SUMO ligase; Transcription, coactivator/corepressor; UBIQUITIN LIGASE; Ubiquitin conjugating system; Ubiquitin ligase Q62318 21849 7|7 A1 mouse K554-sm 2798310 LPGMAIVkEEETEAA transcription, inhibited 17298944 5 2 0 +Cebpb C/EBP-beta DNA-binding; Motility/polarity/chemotaxis; Transcription factor P28033 12608 2 H3|2 87.58 cM mouse T179-p 455887 GSSGSLStSSSSSPP activity, induced; molecular association, regulation; protein conformation cell cycle regulation; cell differentiation, altered; cell differentiation, induced; transcription, induced; transcription, inhibited; signaling pathway regulation; transcription, altered C/EBP-beta(INDUCES) DNA(INDUCES) 15985551; 17264204; 17601773; 19244213; 19478079 6 3 0 +Septin4 SEPT4 Apoptosis; Cell development/differentiation; Cytoskeletal; Hydrolase P28661 18952 11|11 C mouse S100-p 4705460 FSAPAPLsPSSRPRS cell motility, altered 26590424 1 2 1 +DACT1 DACT1 Adaptor/scaffold Q9NYF0 51339 14q23.1 human S827-p 18159800 KKILRFRsGSLKLMT Dapper molecular association, regulation carcinogenesis, altered; cell growth, altered 14-3-3 beta(INDUCES) 21262972 1 1 0 ; modulates Wnt signaling +FOXO3 FOXO3A Autophagy; DNA-binding; Oncoprotein; Transcription factor O43524 2309 6q21 human S574-p 20799900 SAKHQQQsPVSQSMQ intracellular localization apoptosis, induced; transcription, induced; transcription, inhibited 23857333; 26470730; 27669435 5 2 0 +EGFR EGFR EC 2.7.10.1; KINASE; Kinase, protein; Membrane protein, integral; Oncoprotein; Protein kinase, TK; Protein kinase, tyrosine (receptor) P00533 1956 7p11.2 human Y1138-p 457950 TAVGNPEyLNTVQPT molecular association, regulation GRB2(INDUCES); SHC1(INDUCES) 16729043 1 12 58 +PDGFRA PDGFRA EC 2.7.10.1; KINASE; Kinase, protein; Membrane protein, integral; Oncoprotein; Protein kinase, TK; Protein kinase, tyrosine (receptor) P16234 5156 4q12 human Y1018-p 448647 RLSADSGyIIPLPDI molecular association, regulation PLCG1(INDUCES) 11818394; 7535778 5 11 93 +AKAP8 AKAP8 Adaptor/scaffold; Cell cycle regulation; Mitochondrial; RNA-binding O43823 10270 19p13.12 human Y53-p 40420004 TTGATYSyGPASWEA molecular association, regulation 25770215 1 0 0 Phenylalanine mutants inhibited dissociation from nuclear structures; structural chromatin changes +Slc9a3 NHE3 Membrane protein, integral; Membrane protein, multi-pass; Transporter; Transporter, SLC family P26433 24784 1p11 rat S552-p 450899 AEGERRGsLAFIRSP molecular association, regulation; intracellular localization; activity, inhibited SYT1(INDUCES) 11937500; 15687252; 19926819; 20630932; 21593184; 23235337; 24666699; 25656367; 33476711; 33868007; 9933588 27 5 4 +Cebpa C/EBP-alpha DNA-binding; Transcription factor P53566 12606 7 B2|7 21.02 cM mouse S193-p 1868113505 PPPHPHAsPAHLAAP activity, induced; protein degradation; molecular association, regulation; ubiquitination; intracellular localization cell cycle regulation; carcinogenesis, inhibited; carcinogenesis, altered; apoptosis, induced; cell growth, inhibited; transcription, induced; transcription, altered; cell differentiation, induced; cell growth, induced; translation, induced; transcription, inhibited; cell growth, altered CDK2(INDUCES); HDAC1(DISRUPTS); SMARCA2(INDUCES); E2F4(INDUCES); HDAC1(INDUCES); BRMS1L(INDUCES); CDK4(INDUCES); Rb(DISRUPTS); PSMD10(INDUCES); HP1 alpha(INDUCES); p300(INDUCES); C/EBP-beta(INDUCES) DNA(INDUCES) 15107404; 15684384; 16537903; 17290224; 20516642; 20698834; 24273171; 26487680; 27373160; 29159818; 30089269; 34245919 15 0 0 +Gja1 GJA1 Channel, misc.; Membrane protein, integral; Membrane protein, multi-pass; Motility/polarity/chemotaxis P23242 14609 10 B4|10 28.64 cM mouse S282-p 448854 TAPLSPMsPPGYKLV activity, induced; receptor internalization, induced; protein degradation; ubiquitination; intracellular localization cell growth, induced; apoptosis, inhibited 22729691; 25952543; 29959233; 30770876; 30872361 42 7 1 cardiomyocyte homeostasis +Plcb3 PLCB3 Carbohydrate Metabolism - inositol phosphate; EC 3.1.4.11; Phospholipase P51432 18797 19 A|19 5.1 cM mouse S537-p 448450 TSLEPQKsLGEESLS phosphorylation cell motility, induced; signaling pathway regulation 21868363 6 36 7 FAK-Y397 phosphorylation, Tpl2-induced cell migration pathway +YAP1 YAP1 Oncoprotein; Transcription, coactivator/corepressor P46937 10413 11q22.1 human K204-ub 1883364800 TTWQDPRkAMLSQMN protein degradation; ubiquitination carcinogenesis, inhibited; apoptosis, induced; cell motility, inhibited 36280829 1 0 0 +Cux1 CUTL1 DNA-binding; Membrane protein, integral; Transcription factor P53564 13047 5 G2|5 75.96 cM mouse S972-p 457410 VLGLSQGsVSDMLSR CUT molecular association, regulation transcription, altered DNA(DISRUPTS) 9446557 1 0 0 +F2RL1 F2RL1 GPCR, family 1; Membrane protein, integral; Membrane protein, multi-pass; Receptor, GPCR P55085 2150 5q13.3 human T392-p 1870757304 SYSSSSTtVKTSY__ receptor desensitization, induced; molecular association, regulation; phosphorylation signaling pathway regulation ARRB1(INDUCES); ARRB2(INDUCES) 33073187 1 0 0 inhibits ERK phosphorylation and signaling; regulates calcium signaling +CARD11 CARD11 Adaptor/scaffold Q9BXL7 84433 7p22.2 human S893-p 1876333500 SPRLSRAsFLFGQLL molecular association, regulation; enzymatic activity, inhibited; phosphorylation transcription, inhibited; signaling pathway regulation Bcl-10(DISRUPTS); TRAF2(DISRUPTS); cIAP1(DISRUPTS); MALT1(DISRUPTS) 35230873 1 1 0 inhibits JNK phosphorylation and IKB alpha phosphorylation and degradation, inhibits MALT1 activity, thus inhibiting TCR signaling +Fyn Fyn EC 2.7.10.2; KINASE; Kinase, protein; Oncoprotein; Protein kinase, TK; Protein kinase, tyrosine (non-receptor) P39688 14360 10 B1|10 20.51 cM mouse Y28-p 447879 SLNQSSGyRYGTDPT enzymatic activity, inhibited 8144681 2 4 11 Y527F mutation converted Fyn into a dominant oncoprotein, capable of full transformation of rodent fibroblasts. +Sgo1 SGO1 Cell cycle regulation Q9CXH7 72415 17|17 C mouse T146-p 2535905 QQIAVEEtDCPYQTT intracellular localization 18331714 1 0 0 S73A and T146A mutants do not localize to the spindle pole region +MYO3A MYO3A Actin-binding; EC 2.7.11.1; KINASE; Kinase, protein; Motor; Protein kinase, STE; Protein kinase, Ser/Thr (non-receptor) Q8NEV4 53904 10p12.1 human T184-p 29674700 STRHRRNtSVGTPFW Pkinase intracellular localization; enzymatic activity, induced cytoskeletal reorganization 24214986; 25402663 3 3 0 T184A enhances filopodia elongation whereas T184E reduces filopodia elongation. +TWIST1 TWIST1 Cell development/differentiation; DNA-binding; Inhibitor; Transcription regulation Q15672 7291 7p21.1 human T121-p 38546302 NVRERQRtQSLNEAF HLH protein degradation; molecular association, regulation TWIST1(INDUCES) 26759241; 32179550 4 0 0 induces EMT; bimolecular fluorescence complementation (BiFC) assay +YAP1 YAP1 Oncoprotein; Transcription, coactivator/corepressor P46937 10413 11q22.1 human Y444-p 54390605 QQNRFPDyLEAIPGT protein degradation; molecular association, regulation; ubiquitination carcinogenesis, inhibited SIAH1(INDUCES) 35723276 2 0 0 +MEOX2 MEOX2 DNA-binding P50222 4223 7p21.2 human S155-p 36702792 DYGRQALsPAEAEKR intracellular localization; phosphorylation carcinogenesis, induced; cell growth, induced; transcription, induced 35468210 1 6 0 +KIR2DL1 KIR2DL1 Membrane protein, integral; Receptor, misc. P43626 3802 19q13.42 human Y332-p 18500400 PPTDIIVyTELPNAE molecular association, regulation signaling pathway regulation supervillin(INDUCES) 21070852 1 0 0 supervillin is required for KIR2DL1-mediated inhibition of Vav1 and Erk phosphorylation +APP APP Apoptosis; Cell surface; Membrane protein, integral; Receptor, misc.; Transcription factor P05067 351 21q21.3 human C186-pa 62489908 FRGVEFVcCPLAEES APP_Cu_bd molecular association, regulation APP(INDUCES) 27875558 1 0 0 palAPP dimerizes ~4.5 times more efficiently +Dync1i2 DYNC1I2 iso3 Microtubule-binding; Motility/polarity/chemotaxis; Motor Q62871-3 116659 rat S84-p 4033130 PPPMSPSsKSVSTPS molecular association, regulation; protein conformation dynactin 1(DISRUPTS) 28162951 3 11 2 +Pdgfrb PDGFRB EC 2.7.10.1; KINASE; Kinase, protein; Membrane protein, integral; Oncoprotein; Protein kinase, TK; Protein kinase, tyrosine (receptor) Q05030 rat Y578-p 447521 VSSDGHEyIYVDPVQ enzymatic activity, induced cell cycle regulation; cell growth, induced; signaling pathway regulation 23776396 11 1 0 downstream signaling pathway phosphorylation of STAT3, ERK1/2, Akt, and PLCG1 was determined in PDGF-stimulated VSMCs +Axin1 axin 1 Adaptor/scaffold; Tumor suppressor O35625 12005 17 A3.3|17 13.07 cM mouse K858-sm 2407408 FEEKIIGkVEKVD__ DIX protein stabilization; enzymatic activity, induced 12223491; 18632848 2 0 0 induces JNK activity; prevents ubiquitination +CERT1 COL4A3BP EC 2.7.11.9; KINASE; Kinase, protein; Lipid-binding; Protein kinase, Ser/Thr (non-receptor); Protein kinase, atypical Q9Y5P4 10087 5q13.3 human T146-p 125104503 GASGYSAtSTSSFKK molecular association, regulation; activity, inhibited 28652409 0 1 0 reduced PtdIns(4)P binding affinity as well as low ceramide transfer activity, E494R/N495K/P535R/E537K mutations, recovery of both PtdIns(4)P binding and ceramide transfer activity. +Psma1 PSMA1 EC 3.4.25.1; Protease; Proteasome complex Q9R1P4 26440 7 F1|7 59.32 cM mouse K30-ac 31910303 EYAMEAVkQGSATVG Proteasome protein degradation 24037710 0 1 0 +DAPK1 DAPK1 Apoptosis; Autophagy; EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, CAMK; Protein kinase, Ser/Thr (non-receptor) P53355 1612 9q21.33 human Y490-p 487483 HCAAWHGyYSVAKAL Ank_2 enzymatic activity, inhibited; protein conformation carcinogenesis, induced; cell motility, induced; cell adhesion, induced; apoptosis, inhibited 17803936 1 0 0 +Rorc RORC iso2 DNA-binding; Nuclear receptor; Transcription factor P51450-2 19885 3|3 F2.1 mouse K446-ub 56836805 LLAKLPPkGKLRSLC Hormone_recep molecular association, regulation cell differentiation, inhibited; transcription, inhibited SRC-1(DISRUPTS) 27430721 1 1 0 +KCNH2 Kv11.1 Channel, potassium; Membrane protein, integral; Membrane protein, multi-pass; Motility/polarity/chemotaxis Q12809 3757 7q36.1 human S1137-p 4696829 EGPTRRLsLPGQLGA activity, induced; molecular association, regulation; activity, inhibited signaling pathway regulation 14-3-3 eta(INDUCES) 10488078; 10837251; 11953308 3 14 6 +Drgx DRGX DNA-binding Q8BYH0 107751 14|14 B mouse S119-p 18321103 PPVRNINsPPPGDQT activity, induced; protein conformation transcription, altered; transcription, inhibited 24564673; 28049756 2 3 0 +ARHGAP24 ARHGAP24 GAP; GAP, Rac/Rho; Motility/polarity/chemotaxis Q8N264 83478 4q21.23-q21.3 human S391-p 484901 RSSMNNGsPTALSGS activity, induced cytoskeletal reorganization 16862148 1 12 0 membrane blebbing +VCL Vinculin Cell adhesion; Cytoskeletal; Motility/polarity/chemotaxis P12003 396422 chicken Y822-p 450873 KSFLDSGyRILGAVA Vinculin molecular association, regulation; phosphorylation cell growth, inhibited; cell motility, inhibited; cell adhesion, inhibited PXN(DISRUPTS); talin 1(DISRUPTS) 37248996 5 45 1609 inhibits MLC phosphorylation +IRF4 IRF4 DNA-binding; Oncoprotein; Transcription factor Q15306 3662 6p25.3 human Y122-p 473657 QLDISDPyKVYRIVP IRF activity, induced transcription, induced 23804646 2 1 3 +LEF1 LEF-1 DNA-binding; Transcription factor Q9UJU2 51176 4q25 human S166-p 11499000 TYSDEHFsPGSHPSH CTNNB1_binding activity, induced; molecular association, regulation transcription, induced; signaling pathway regulation; transcription, inhibited HDAC1(DISRUPTS) 12556497; 22373574 2 0 1 Wnt/beta-catenin signalling pathway +ZAP70 ZAP70 EC 2.7.10.2; KINASE; Kinase, protein; Protein kinase, TK; Protein kinase, tyrosine (non-receptor) P43403 7535 2q11.2 human Y315-p 448867 MPMDTSVyESPYSDP activity, induced; molecular association, regulation; protein conformation; enzymatic activity, induced; phosphorylation cell differentiation, altered; cell adhesion, altered; signaling pathway regulation CD3G(DISRUPTS); CRK(INDUCES); VAV1(INDUCES) 11514605; 15100278; 16339550; 26237552; 30992398 12 4 265 +MDM2 MDM2 EC 6.3.2.-; EC 6.3.2.19; Inhibitor; Ligase; NEDDYLATION LIGASE; Neddylation Ligase; Nucleolus; Oncoprotein; UBIQUITIN LIGASE; Ubiquitin conjugating system; Ubiquitin ligase Q00987 4193 12q15 human T351-p 17342607 KAKLENStQAEEGFD intracellular localization 27264869 2 1 0 phosphorylation inhibits MDM2 recruitment to chromatin +Ppp2r1a PPP2R1A Motility/polarity/chemotaxis; PHOSPHATASE; Protein phosphatase, regulatory subunit Q5XI34 117281 1q12 rat S303-p 31006104 AEVRAAAsHKVKEFC HEAT molecular association, regulation; protein conformation PPP2CA(DISRUPTS) 24465463 1 1 0 defect in holoenzyme assembly +GABARAPL2 GABARAPL2 Adaptor/scaffold; Autophagy; Microtubule-binding; Ubiquitin-like modifier; Vesicle P60520 11345 16q23.1 human S87-p 1869546303 VDKTVPQsSLTMGQL ATG8 molecular association, regulation apoptosis, induced ATG4B(DISRUPTS) 31709703 1 1 0 ; including ATG4A, ATG4C, ATG4D +DCBLD2 DCBLD2 Cell adhesion; Membrane protein, integral Q96PD2 131566 3q12.1|3 human Y565-p 458665 KKKTEGTyDLPYWDR molecular association, regulation CRKL(INDUCES) 23770091 2 11 52 +WASF2 WAVE2 Actin-binding; Motility/polarity/chemotaxis Q9Y6W5 10163 1p36.11 human S343-p 18715501 PPPVGFGsPGTPPPP molecular association, regulation cell motility, altered; cytoskeletal reorganization 21419341 1 0 0 regulates WRC (WAVE2 regulatory complex) interaction with Arp2/3 and lamellipodial protrusion +TP53BP1 53BP1 DNA repair, damage; Transcription, coactivator/corepressor Q12888 7158 15q15.3 human S625-p 481851 DLTCDSGsQAVPSPA molecular association, regulation DNA repair, induced RIF1(INDUCES) 31390554 1 1 0 regulates Rif1 localization +CDC73 CDC73 Cell cycle regulation; Tumor suppressor Q6P1J9 79577 1q31.2 human Y315-p 15402684 KIDTMGTyHGMTLKS molecular association, regulation; protein conformation transcription, inhibited; signaling pathway regulation CTNNB1(DISRUPTS) 21726809 1 1 1 inhibits Wnt signaling pathway +DLC1 DLC1 GAP; GAP, Rac/Rho; Tumor suppressor Q96QB1 10395 8p22 human S1244-p 17538201 NTLKRENsSPRVMQR activity, inhibited cell growth, altered 21087603 1 2 0 +PHOX2A PHOX2A DNA-binding; Transcription factor O14813 401 11q13.4 human S153-p 9400302 RKQERAAsAKGAAGA molecular association, regulation; activity, inhibited transcription, inhibited DNA(DISRUPTS) 19564421 1 1 1 inhibits neuronal differentiation; dominant-negative effect on PHOX2A activity +MDC1 MDC1 Cell cycle regulation Q14676 9656 6p21.33 human S402-p 3196337 QASMVINsDTDDEEE molecular association, regulation cell cycle regulation NBS1(INDUCES) 18678890 1 27 8 MDC1-NBS1 interaction regulates intra-S-phase checkpoint activation +Dyrk1a DYRK1A EC 2.7.12.2; KINASE; Kinase, protein; Protein kinase, CMGC; Protein kinase, dual-specificity (non-receptor) Q63470 25255 11q11 rat Y319-p 457973 CQLGQRIyQYIQSRF Pkinase enzymatic activity, induced 8631952 1 15 177 +SHC1 SHC1 iso3 Adaptor/scaffold; Apoptosis; Mitochondrial; Motility/polarity/chemotaxis P29353-3 6464 1q21.3 human Y272-p 448511 ELFDDPSyVNVQNLD phosphorylation 9566877 42 91 1971 Either FAK Y925 or Shc1 Y317 need to be phosphorylated after fibronectin to bind Grb2 to effficiently activate ERKs. +NFE2L2 NRF2 DNA-binding; Transcription factor Q16236 4780 2q31.2 human S351-p 18258503 SGISLNTsPSVASPE protein degradation; molecular association, regulation BTRC(DISRUPTS) 22751928; 32295843 3 1 0 +Mavs MAVS Adaptor/scaffold; Membrane protein, integral Q8VCF0 228607 2|2 F1 mouse K7-sc 33344549 _MTFAEDkTYKYIRD CARD_2 activity, induced 32301534 1 2 0 cellular antiviral response +Prkaca PKACA EC 2.7.11.11; KINASE; Kinase, protein; Protein kinase, AGC; Protein kinase, Ser/Thr (non-receptor) P05132 18747 8|8 C2 mouse T196-p 454125 AKRVKGRtWTLCGTP Pkinase phosphorylation cell motility, induced; cytoskeletal reorganization; signaling pathway regulation 31387938 1 26 77 induces activity towards p38 thereby increasing its, regulates PKA signaling +ATF4 ATF-4 DNA-binding; Transcription factor P18848 468 22q13.1 human S215-p 27833501 IKEEDTPsDNDSGIC protein degradation transcription, induced; signaling pathway regulation 23123191 2 1 0 ER-stress signaling pathway +Mapkapk2 MAPKAPK2 EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, CAMK; Protein kinase, Ser/Thr (non-receptor) P49138 17164 1|1 E4 mouse T208-p 448269 TSHNSLTtPCYTPYY Pkinase enzymatic activity, induced 7592979 14 3 42 +NRIP1 RIP140 Nuclear receptor co-regulator; Transcription, coactivator/corepressor P48552 8204 21q11.2-q21.1 human R649-m1 2363401 SMSVEEQrPSKQLLT NRIP1_repr_2 molecular association, regulation; intracellular localization transcription, induced Exportin-1(INDUCES) DNA(DISRUPTS) 17053781 2 2 0 +PTOV1 PTOV1 Q86YD1 53635 19q13.33 human S53-p 4767655 PPRIRARsAPPMEGA protein stabilization; molecular association, regulation; intracellular localization 14-3-3 zeta(INDUCES); HUWE1(DISRUPTS) 34654719 1 24 11 +NPR2 ANPB EC 4.6.1.2; Guanylyl cyclase; KINASE; Kinase, protein; Lyase; Membrane protein, integral; Nucleotide Metabolism - purine; Protein kinase, RGC; Protein kinase, dual-specificity (receptor); Receptor, misc. P20594 4882 9p13.3 human Y808-p 27930810 LLLRMEQyANNLEKL enzymatic activity, altered 23586811 1 0 0 +GRK2 GRK2 EC 2.7.11.15; KINASE; Kinase, protein; Protein kinase, AGC; Protein kinase, Ser/Thr (non-receptor) P21146 282682 cow Y92-p 456873 FYEEIKKyEKLETEE RGS enzymatic activity, induced 18463167 5 0 0 +Rbl2 Rb-like 2 Transcription, coactivator/corepressor; Tumor suppressor Q64700 19651 8 C4|8 44.25 cM mouse S1076-p 449741 IFYYFSNsPSKRLRE transcription, induced 35385527 5 10 0 +YAP1 YAP1 iso2 Oncoprotein; Transcription, coactivator/corepressor P46937-2 10413 11q22.1 human S351-p 471290 GTQNPVSsPGMSQEL apoptosis, inhibited; transcription, induced 22308035 8 29 12 YAP phosphorylation is required for anti-apoptotic activity of YAP in cells which are deficient in p73 alpha/beta expression. +Cebpa C/EBP-alpha DNA-binding; Transcription factor P53566 12606 7 B2|7 21.02 cM mouse T222-p 449824 HLQPGHPtPPPTPVP transcription, induced; transcription, inhibited 10567568; 17290224 8 0 0 +Wnk4 WNK4 EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, Other; Protein kinase, Ser/Thr (non-receptor) Q80UE6 69847 11|11 D mouse S332-p 456207 KRASFAKsVIGTPEF Pkinase phosphorylation; enzymatic activity, induced 28096417; 29921588; 34289367 5 11 3 +KIF20A KIF20A Microtubule-binding; Motor O95235 10112 5q31.2 human S867-p 459835 CQSSTDCsPYARILR molecular association, regulation; intracellular localization; protein conformation cell cycle regulation AurB(DISRUPTS); INCENP(DISRUPTS) 24656812 1 12 17 favours solubility, inhibits microtubule binding +MYH7 MYH7 Motility/polarity/chemotaxis; Motor P12883 4625 14q11.2 human T215-p 17551501 DQSPGKGtLEDQIIQ Myosin_head protein conformation 35502901 0 3 0 +PRKAA2 AMPKA2 Autophagy; EC 2.7.11.1; EC 2.7.11.27; EC 2.7.11.31; KINASE; Kinase, protein; Protein kinase, CAMK; Protein kinase, Ser/Thr (non-receptor) P54646 5563 1p32.2 human S491-p 450432 STPQRSCsAAGLHRP AdenylateSensor cell growth, induced; autophagy, altered 27390127; 35595099 13 12 2 +ADRB2 ADRB2 GPCR, family 1; Membrane protein, integral; Membrane protein, multi-pass; Receptor, GPCR P07550 154 5q32 human S345-p 447910 ELLCLRRsSLKAYGN receptor desensitization, inhibited; receptor recycling, inhibited; receptor desensitization, altered; intracellular localization cytoskeletal reorganization 11146000; 24003153; 27646272; 9461522 11 2 0 +FZR1 FZR1 UBIQUITIN LIGASE; Ubiquitin conjugating system Q9UM11 51343 19p13.3 human T32-p 3215934 TEMRRTLtPASSPVS protein stabilization 30498084 1 6 2 AURKA stabilization +UBA2 SAE2 EC 6.3.2.-; EC 6.3.2.19; Ligase; Motility/polarity/chemotaxis; SUMO LIGASE; SUMO conjugating system; SUMO ligase; UBIQUITIN LIGASE; Ubiquitin conjugating system; Ubiquitin ligase Q9UBT2 10054 19q13.11 human K630-sm 10304921 KRSRIEQkEELDDVI UBA2_C intracellular localization 23095757 2 3 0 nuclear localization +ELAVL1 HuR RNA-binding Q15717 1994 19p13.2 human R217-me 477190 PVHHQAQrFRFSPMG RNA stability, altered 23837869 2 0 0 represses replicative senescence, differential regulation of mRNA stability +FAM83A FAM83A Unknown function Q86UY5 84985 8q24.13 human Y138-p 463316 EKSSATVyFQTVKHN FAM83 ubiquitination; intracellular localization carcinogenesis, induced; cell growth, induced; transcription, induced; signaling pathway regulation 36797256 1 3 164 regulates ?-catenin nuclear translocation, ubiquitination and stability, enhances Wnt/?-catenin signaling +PDHA1 PDHA1 Amino Acid Metabolism - valine, leucine and isoleucine biosynthesis; Carbohydrate Metabolism - butanoate; Carbohydrate Metabolism - citrate (TCA) cycle; Carbohydrate Metabolism - glycolysis and gluconeogenesis; Carbohydrate Metabolism - pyruvate; EC 1.2.4.1; Mitochondrial; Oxidoreductase P08559 5160 Xp22.12 human K83-ac 1196409 LKADQLYkQKIIRGF E1_dh enzymatic activity, inhibited 33327751 1 3 8 IL-1? production, NLRP3 in?ammasome activation, lactate accumulation +Ager RAGE Cell cycle regulation; Membrane protein, integral; Motility/polarity/chemotaxis; Receptor, misc. Q62151 11596 17|17 B1 mouse S376-p 4731271 EERKAPEsQEDEEER intracellular localization DNA repair, induced; carcinogenesis, induced; signaling pathway regulation 23318458; 28977635 2 2 0 +TP73 p73 DNA-binding; Transcription factor; Tumor suppressor O15350 7161 1p36.32 human T86-p 449047 AASASPYtPEHAASV protein degradation; intracellular localization; activity, inhibited carcinogenesis, induced; cell growth, induced; apoptosis, induced; chromatin organization, altered; apoptosis, inhibited; transcription, inhibited p73(DISRUPTS) 12676926; 15985436; 22002055; 36721000 4 0 0 +Pdpk1 PDK1 EC 2.7.11.1; KINASE; Kinase, protein; Nuclear receptor co-regulator; Protein kinase, AGC; Protein kinase, Ser/Thr (non-receptor) Q9Z2A0 18607 17|17 A3.3 mouse S163-p 465670 EKLYFGLsYAKNGEL Pkinase protein conformation; enzymatic activity, induced 16751192 1 1 0 +MALT1 MALT1 Adaptor/scaffold; Apoptosis; EC 3.4.22.-; Ligase; Nuclear export; Protease; UBIQUITIN LIGASE; Ubiquitin conjugating system Q9UDY8 10892 18q21.32 human K714-ub 2134707 VGKPLIAkLDMHRGL MALT1_Ig protein degradation; molecular association, regulation IKKA(INDUCES) 17948050 1 1 0 activation of NF-kB pathway and IL-2 induction +GFAP GFAP Cytoskeletal P14136 2670 17q21.31 human Y242-p 462302 LKEIRTQyEAMASSN Filament cytoskeletal reorganization 24003221 1 1 2 +YWHAZ 14-3-3 zeta Adaptor/scaffold; Motility/polarity/chemotaxis P63104 7534 8q22.3 human S58-p 449833 VVGARRSsWRVVSSI 14-3-3 protein degradation; molecular association, regulation; intracellular localization apoptosis, altered 14-3-3 zeta(DISRUPTS); 14-3-3 zeta(INDUCES); ASK1(DISRUPTS); Tau iso3(DISRUPTS); 14-3-3 epsilon(DISRUPTS); p53(DISRUPTS); HSP20(DISRUPTS) 11956222; 16376338; 18559254; 19451227; 21081103; 35321476 15 1 5 +ATP4A ATP4A EC 3.6.3.10; Energy Metabolism - oxidative phosphorylation; Hydrolase; Membrane protein, integral; Membrane protein, multi-pass; Transporter; Transporter, ion channel P20648 495 19q13.12 human Y7-p 484289 _MGKAENyELYSVEL H-K_ATPase_N protein conformation 12480547 3 0 10 Structure indicates tyrosine sequential phosphorylation at Y10 and subsequent Y7 which may induce activation of ATP4A. +SMC3 SMC3 Cell cycle regulation; DNA repair, damage Q9UQE7 9126 10q25.2 human S1067-p 453059 GDVEGSQsQDEGEGS SMC_N phosphorylation cell cycle regulation 18442975 2 59 45 facilitates phosphorylation of S1083; required for intra-S phase checkpoint +NFKBIA IkB-alpha DNA-binding; Inhibitor P25963 4792 14q13.2 human S283-p 451523 NLQMLPEsEDEESYD protein degradation 8657113 3 1 0 S283/T291/T299A triple mutant showed increased IkB-alpha stability. +MAF MAF Cell development/differentiation; DNA-binding; Oncoprotein; Transcription factor; Tumor suppressor O75444 4094 16q23.2 human S70-p 487503 PCSSVPPsPSFSAPS transcription, altered 17897790 1 0 0 sites behave in a dramatic cell type-specific manner +DIAPH2 Diaphanous-2 iso4 Cytoskeletal; Motility/polarity/chemotaxis Q17R91 1730 Xq21.33 human S820-p 18707505 HINNIKPsIIAVTLA FH2 cell cycle regulation; chromatin organization, altered; cytoskeletal reorganization 21397845 1 0 0 mutation of this site disrupts metaphase chromosome alignment +TET1 TET1 DNA-binding; EC 1.14.11.n2; Oxidoreductase Q8NFU7 80312 10q21.3 human S1976-p 1881549504 PPSDEPLsDDPLSPA protein stabilization carcinogenesis, induced; cell growth, induced; apoptosis, inhibited; transcription, induced 36989375 1 0 0 +Hsf1 HSF1 DNA-binding; Transcription factor P38532 15499 15 D3|15 35.95 cM mouse T142-p 449066 DSVTRLLtDVQLMKG molecular association, regulation; protein conformation apoptosis, inhibited; transcription, induced 24312621 4 1 0 critical oxidative stress-responsive circadian transcriptome; BMAL1-HSF1 dimerization +SNAI1 Snail1 C2H2-type zinc finger protein; Transcription factor O95863 6615 20q13.13 human K146-ac 1877752103 LAQLSEAkDLQARKA protein degradation; molecular association, regulation; ubiquitination carcinogenesis, induced BTRC(INDUCES); FBXL14(INDUCES); BRD4(INDUCES) 31311807 1 0 0 BRD4 interacts with acetylated Snail to suppress its ubiquitination and degradation by competing with FBXL14 and BRD8 for binding to Snail1 +TUBB4A TUBB4 Cytoskeletal; Motility/polarity/chemotaxis P04350 10382 19p13.3 human K19-m1 58123406 CGNQIGAkFWEVISD Tubulin molecular association, regulation L3MBTL iso4(INDUCES) 23583077 0 1 0 +Nrl NRL DNA-binding; Transcription factor P54846 18185 14 C3|14 28.19 cM mouse S50-p 478419 PYSSVPPsPTFSEPG molecular association, regulation chromatin organization, altered; transcription, induced Tip60(INDUCES) DNA(INDUCES) 22354990 2 0 1 +KDM1A LSD1 DEMETHYLASE; Demethylase; EC 1.-.-.-; Nuclear receptor co-regulator; Oxidoreductase; Transcription factor O60341 23028 1p36.12 human S111-p 3828907 TPEGRRTsRRKRAKV cell motility, induced; cell growth, induced DNA(INDUCES) 27572339 4 1 10 epithelial-mesenchymal transition (EMT), facilitated the H3K4me demethylation +CASP8 CASP8 iso4 Apoptosis; EC 3.4.22.61; Protease Q14790-4 841 2q33.1 human K215-ub 573769294 NDYEEFSkGEELCGV ubiquitination apoptosis, inhibited 30807646 1 3 0 CUL7 ubiquitination inhibits Caspase-8 cleavage and apoptosis +Clic4 CLIC4 Membrane protein, integral Q9QYB1 29876 4|4 D3 mouse S108-p 4782152 PPKYLKLsPKHPESN protein stabilization apoptosis, induced 30237421 1 4 0 +Cbx3 CBX3 DNA-binding P23198 12417 6 B3|6 24.89 cM mouse S93-p 457001 KDGTKRKsLSDSESD intracellular localization transcription, induced 26021315 5 57 61 P-Ser83-HP1 colocalized with Centrin-2 in sperm mid-piece, early embryonic genome activation, regulation of mitosis-associated gene expression networks +Ppp1r1b DARPP-32 Motility/polarity/chemotaxis; Protein phosphatase, regulatory subunit Q60829 19049 11|11 D mouse S97-p 457675 NLSENQAsEEEDELG DARPP-32 molecular association, regulation; intracellular localization; phosphorylation signaling pathway regulation PPP1CA(INDUCES) 18496528; 36055413 8 13 23 inhibits GluR1 dephosphorylation, thus inducing DARPP-32-PP1-GRIA1 signaling +H3C1 H3 DNA-binding P68431 8350 6p22.2 human K115-ac 3652257 NLCAIHAkRVTIMPK Histone molecular association, regulation chromatin organization, altered polybromo 1(INDUCES) DNA(DISRUPTS) 19520870; 20368734 2 1 42 acetylation facilitates nucleosome repositioning; varying site specificity binding for each bromodomain 1-6 +PHLDA1 PHLDA1 Apoptosis; Nucleolus Q8WV24 22822 12q21.2 human S95-p 22459800 PLCLLRVsLLCALRA protein degradation; intracellular localization carcinogenesis, induced; cell motility, induced; apoptosis, induced 21807936 1 0 0 ; S95A mutant promotes Aurora A degradation and ubiquitylation +IQCB1 IQCB1 Cell development/differentiation Q15051 9657 3q13.33|3q21.1 human K528-ub 95155300 LMKAPSLkEAEGKEP intracellular localization cell cycle regulation; cytoskeletal reorganization 28498859 1 2 0 regulation of cilia formation +SUPT5H SPT5 RNA-binding; Transcription, coactivator/corepressor O00267 6829 19q13.2 human T784-p 458816 MYGSGSRtPMYGSQT transcription, induced; transcription, altered 10757782; 16427012 2 2 12 required for c-fos induction and activation in vivo +Rab3il1 RAB3IL1 GEF; GEF, Rab Q8VDV3 74760 19|19 A mouse S169-p 467058 VITSTPAsPNRELHP Sec2p exocytosis, induced; cell differentiation, induced 28096466 2 21 35 required for myogenesis and promotes IL-6 secretion in skeletal muscle +ANTXR2 ANTXR2 Membrane protein, integral; Receptor, misc. P58335 118429 4q21.21 human Y380-p 3781577 WPTVDASyYGGRGVG ubiquitination 20080640 1 10 110 +Card11 CARD11 Adaptor/scaffold Q8CIS0 108723 5|5 G2 mouse S564-p 457637 QPHRSRSsIMSITAE activity, induced; molecular association, regulation; enzymatic activity, induced signaling pathway regulation Bcl-10(INDUCES) 16356855; 19917688; 31391255 7 1 0 antigen receptor signaling +GLI3 GLI3 C2H2-type zinc finger protein; Transcription factor P10071 2737 7p14.1 human K773-ub 6097711 RRNPAGTkWMEHVKL protein processing 16705181 1 0 0 +Hnrnpa1 hnRNP A1 Nuclear export; RNA splicing; RNA-binding; Spliceosome P04256 29578 7q36 rat S95-p 476057 RAVSREDsQRPGAHL activity, inhibited 7727389 1 16 23 +ERG ERG DNA-binding; Oncoprotein; Transcription factor P11308 2078 21q22.2 human S38-p 50259802 TEMTASSsSDYGQTS protein degradation; molecular association, regulation cell motility, inhibited SPOP(INDUCES) 26344095 1 1 0 +CDC25B CDC25B EC 3.1.3.48; Motility/polarity/chemotaxis; Nuclear receptor co-regulator; PHOSPHATASE; Protein phosphatase, dual-specificity P30305 994 20p13 human T355-p 3189697 NKRRRSVtPPEEQQE M-inducer_phosp cell cycle regulation 23708659 1 2 5 +CHMP7 CHMP7 Q8WUX9 91782 8p21.3 human S441-p 4763991 GLVPSSKsPKRQLEP Snf7 molecular association, regulation cell cycle regulation CHMP7(DISRUPTS); LEMD2(DISRUPTS) 34286694 1 8 0 +FOXP3 FOXP3 C2H2-type zinc finger protein; Cell cycle regulation; DNA-binding; Transcription factor Q9BZS1 50943 Xp11.23 human S270-p 56786300 KMALTKAsSVASSDK protein degradation; ubiquitination 27432879 1 1 0 +PTPN6 SHP-1 EC 3.1.3.48; Motility/polarity/chemotaxis; PHOSPHATASE; Protein phosphatase, tyrosine (non-receptor) P29350 5777 12p13.31 human S557-p 11086952 AKASRTSsKHKEDVY enzymatic activity, induced cell adhesion, induced; signaling pathway regulation 21177494 1 6 68 Src activation via SHP-1 and SHP-2, and then ERK activation +Xrcc6 Ku70 DNA repair, damage; DNA-binding; EC 3.6.4.-; EC 4.2.99.-; Helicase; Nuclear receptor co-regulator; RNA-binding P23475 14375 15 E1|15 38.33 cM mouse K568-m3 1883494505 ELKAHFRkGTLGKLT intracellular localization apoptosis, inhibited 35545041 1 0 0 enriched in cytoplasm, the methylation of KU70-K570 is a prerequisite for the acetylation of KU70 +Traf6 TRAF6 EC 6.3.2.-; Ligase; UBIQUITIN LIGASE; Ubiquitin conjugating system; Ubiquitin ligase P70196 22034 2|2 E2 mouse T330-p 60176100 ELTAKMEtQSMYVGE intracellular localization 27818144 1 0 0 nuclear localization +Ntsr2 NTSR2 GPCR, family 1; Membrane protein, integral; Membrane protein, multi-pass; Receptor, GPCR P70310 18217 12 A1.1|12 7.98 cM mouse Y237-p 3129400 VNHLVALySQVPSAS 7tm_1; TM receptor recycling, altered 11801734 1 0 0 NT stimulation led to large intracellular vesicles under the plasma membrane in the Y238A mutant. +NR3C2 MCR DNA-binding; Nuclear receptor P08235 4306 4q31.23 human S196-p 25692901 EKSPSVCsPLNMTSS protein degradation; ubiquitination transcription, inhibited 22798426 1 0 0 +ACTN1 ACTN1 Cytoskeletal; Motility/polarity/chemotaxis P12814 87 14q24.1|14q22-q24 human Y12-p 450200 DSQQTNDyMQPEEDW molecular association, regulation; phosphorylation cell motility, altered; cytoskeletal reorganization Src(INDUCES); ITGA2B(INDUCES) 16291744; 20940419; 23454549 4 2 3 required for dorsal stress fiber establishment, transverse arc maintenance, and focal adhesion maturation; inhibits PAR1-induced ITGA2b activation in CMK; Phosphorylation of ACTN1 Y12 is required for PTP 1B to dephosphorylate FAK Y397. Y12F mutation or no expression of ACTN1 significantly decreases the FAK Y397 dephosphorylation by PTP 1B. Src's binding to phospho-Y12 ACTN1 competes with Src's binding to FAK. +CENPQ CENPQ Q7L2Z9 55166 6p12.3 human S138-p 18007846 MEDLTNVsSLLNMER CENP-Q molecular association, regulation; intracellular localization DNA(DISRUPTS) 25670858 1 5 0 CENPQ phosphorylation promotes the delocalization of the PBIP1-CENPQ complex from kinetochores +Clec7a dectin-1 Membrane protein, integral Q6QLQ4 56644 6|6 F3 mouse Y15-p 36396303 ENLDEDGyTQLDFST molecular association, regulation endocytosis, induced; transcription, induced; signaling pathway regulation Syk(INDUCES); SHIP(INDUCES); Cbl-b(DISRUPTS) 25246527; 26416276; 27428899 3 1 0 +CD247 CD3Z Membrane protein, integral; Receptor, misc. P20963 919 1q24.2 human Y123-p 448934 KDKMAEAySEIGMKG ITAM intracellular localization; phosphorylation 16919488; 18760640 3 13 314 +STAM2 STAM2 Adaptor/scaffold; Motility/polarity/chemotaxis O75886 10254 2q23.3 human Y371-p 449670 LVNEAPVySVYSKLH molecular association, regulation UBE2D2(DISRUPTS) 18626516 1 26 440 +EEF2K EEF2K EC 2.7.11.20; KINASE; Kinase, protein; Protein kinase, Ser/Thr (non-receptor); Protein kinase, atypical; Translation O00418 29904 16p12.2 human S398-p 450686 DSLPSSPsSATPHSQ autophagy, induced; apoptosis, inhibited 23182879 3 2 2 +Tnni3 TNNI3 Actin-binding; Motility/polarity/chemotaxis; Motor P23693 29248 1q12 rat S151-p 451822 TLRRVRIsADAMMQA Troponin molecular association, regulation; protein conformation TNNC1(INDUCES) 20540949 9 4 0 sensitizes structural changes to Ca2+ +DAP DAP Autophagy P51397 1611 5p15.2 human S51-p 471098 DQEWESPsPPKPTVF DAP activity, inhibited autophagy, altered 20537536 1 54 1 dephosphorylated form of DAP acts as an active suppressor of autophagy +Ksr1 KSR KINASE; Kinase, protein; Protein kinase, Ser/Thr (non-receptor); Protein kinase, TKL Q61097 16706 11 B5|11 46.74 cM mouse T274-p 449299 AKLKPPRtPPPPSRK protein degradation; intracellular localization cell cycle regulation; cell growth, altered 11741955; 15371409 4 6 1 +PRL prolactin Cytokine; Motility/polarity/chemotaxis; Secreted; Secreted, signal peptide P01236 5617 6p22.3 human S207-p 451732 LHCLRRDsHKIDNYL Hormone_1 protein conformation 19555049 3 1 0 phosphorylated form of prolactin has a higher affinity for heparin +PPP2R5A PPP2R5A Motility/polarity/chemotaxis; Protein phosphatase, regulatory subunit Q15172 5525 1q32.3 human S41-p 3196904 RQKRSQGsSQFRSQG enzymatic activity, inhibited 24225947 1 33 38 increases Ca++ release +SH3BP2 SH3BP2 Adaptor/scaffold P78314 6452 4p16.3 human Y183-p 449092 HDDEDDSyLEPDSPE molecular association, regulation transcription, altered VAV1(INDUCES) 15751964 4 0 0 +HNRNPK hnRNP K RNA splicing; RNA-binding; Spliceosome P61978 3190 9q21.32 human K139-m1 58123401 CLNYQHYkGSDFDCE molecular association, regulation L3MBTL iso4(INDUCES) 23583077 0 1 0 +GRB2 GRB2 Adaptor/scaffold; Cell development/differentiation; Motility/polarity/chemotaxis P62993 2885 17q25.1 human Y209-p 448512 TGMFPRNyVTPVNRN molecular association, regulation cell growth, induced; cell growth, altered SOS1(DISRUPTS) 11726515; 19273609; 36163549 4 4 216 +Cry1 CRY1 DNA-binding; Lyase; Transcription, coactivator/corepressor P97784 12952 10 C1|10 41.63 cM mouse S588-p 11952906 LSSGKRPsQEEDAQS protein stabilization 24158435 2 9 0 lengthened circadian periods +Eif4ebp1 4E-BP1 Translation; Translation initiation Q60876 13685 8 A2|8 15.95 cM mouse T45-p 447496 GGTLFSTtPGGTRII eIF_4EBP molecular association, regulation transcription, induced; translation, induced; signaling pathway regulation EIF4E(DISRUPTS); EIF4E(INDUCES) 11875068; 17510058; 18851840; 33567340; 34704268 156 36 91 +Plcg1 PLCG1 Carbohydrate Metabolism - inositol phosphate; EC 3.1.4.11; Motility/polarity/chemotaxis; Phospholipase P10686 25738 3q42 rat Y771-p 448575 IGTAEPDyGALYEGR enzymatic activity, induced 1708307 16 41 552 Y1253F inhibited full activation. ; Y771F mutation completely blocked activation, while Y774F enhanced activation +CDK11B CDK11B Apoptosis; Cell cycle regulation; EC 2.7.11.22; KINASE; Kinase, protein; Motility/polarity/chemotaxis; Protein kinase, CMGC; Protein kinase, Ser/Thr (non-receptor) P21127 984 1p36.33 human S115-p 455902 KRRHRSHsAEGGKHA molecular association, regulation 14-3-3 beta(INDUCES); 14-3-3 theta(INDUCES); 14-3-3 epsilon(INDUCES); 14-3-3 gamma(INDUCES) 15883043 1 6 5 +Coro1a coronin 1A Cytoskeletal; Motility/polarity/chemotaxis O89053 12721 7 69.25 cM|7 F3 mouse S426-p 31905585 PEPSGTPsSDTVSRL Trimer_CC molecular association, regulation; enzymatic activity, induced PPM1D(INDUCES) 37386173 1 5 0 induces PLC activity +TH TH iso4 Amino Acid Metabolism - tyrosine; EC 1.14.16.2; Endoplasmic reticulum; Mitochondrial; Oxidoreductase; Vesicle P07101-4 7054 11p15.5 human S44-p 448545 RFIGRRQsLIEDARK TOH_N enzymatic activity, induced 7901013 62 11 11 +MAPK7 ERK5 EC 2.7.11.24; KINASE; Kinase, protein; Protein kinase, CMGC; Protein kinase, Ser/Thr (non-receptor) Q13164 5598 17p11.2 human K22-sm 2887212 AEPPGPVkAEPAHTA molecular association, regulation; intracellular localization cell growth, induced; transcription, induced HSP90A(DISRUPTS) 32209980 4 0 0 nuclear translocation; Hsp90 dissociation from the ERK5-Cdc37 complex +ADAR ADAR EC 3.5.4.37; Hydrolase; Nucleolus; RNA processing; RNA-binding P55265 103 1q21.3 human T1033-p 1868546602 RLGERLRtMSCSDKI A_deamin enzymatic activity, inhibited 31095429 1 0 0 +BACE1 BACE EC 3.4.23.46; Membrane protein, integral; Protease P56817 23621 11q23.3 human K300-ac 478254 TNLRLPKkVFEAAVK Asp protein stabilization; intracellular localization 17425515 1 1 0 regulates translocation through secretory pathway +Grin1 NMDAR1 Channel, calcium; Channel, ligand-gated; Membrane protein, integral; Membrane protein, multi-pass P35439 24408 3p13 rat S584-p 1871177708 LYLLDRFsPFGRFKV Lig_chan intracellular localization; activity, inhibited cell cycle regulation 33184446 1 0 0 +Pip5k1c PIP5K1C Carbohydrate Metabolism - inositol phosphate; EC 2.7.1.68; Kinase, lipid; Motility/polarity/chemotaxis O70161 18717 10|10 C1 mouse Y644-p 450241 TDERSWVySPLHYSA molecular association, regulation; intracellular localization; enzymatic activity, induced cytoskeletal reorganization talin 1(INDUCES) 14691141; 15623515 6 0 0 +SIRT1 SIRT1 Apoptosis; DEACETYLASE; Deacetylase; EC 3.5.1.-; Nuclear receptor co-regulator Q96EB6 23411 10q21.3 human K622-me 58128900 SVAGTVRkCWPNRVA molecular association, regulation L3MBTL iso4(INDUCES) 23583077 1 1 0 +FCRL3 FCRL3 Adaptor/scaffold; Membrane protein, integral Q96P31 115352 1q23.1 human Y662-p 469981 PGDSNPIySQIWSIQ molecular association, regulation ZAP70(INDUCES) 12051764 1 0 0 +CTBP2 CTBP2 Nuclear receptor co-regulator; Transcription, coactivator/corepressor P56545 1488 10q26.13 human K10-ac 461009 LVDKHKVkRQRLDRI intracellular localization transcription, induced 16356938 1 0 0 reduction of acetylation represses transcription +GALNT2 GALNT2 EC 2.4.1.41; Glycan Metabolism - O-glycan biosynthesis; Membrane protein, integral; Transferase Q10471 2590 1q42.13 human S529-ac 25336510 WEQIEGNsKLRHVGS Ricin_B_lectin molecular association, regulation; protein conformation Other(INDUCES) 21651894 0 1 0 induces binding to glycan +Rasgrf1 RASGRF1 GEF; GEF, Ras P28818 192213 8q31 rat S575-p 18710202 QEKAAWTsDIIQCVD PH protein degradation 21382555 1 1 0 +CENPQ CENPQ Q7L2Z9 55166 6p12.3 human T256-p 40245502 SQMKSMStFIEEAYK CENP-Q molecular association, regulation; intracellular localization DNA(DISRUPTS) 25670858 1 1 0 CENPQ phosphorylation promotes the delocalization of the PBIP1-CENPQ complex from kinetochores +NR3C1 GR DNA-binding; Mitochondrial; Nuclear receptor; Transcription factor P04150 2908 5q31.3 human K480-ac 6741601 CPACRYRkCLQAGMN zf-C4 molecular association, regulation transcription, inhibited DNA(DISRUPTS) 19141540 1 0 0 +NFATC1 NFAT2 DNA-binding; Transcription factor O95644 4772 18q23 human S269-p 448862 PCNKRKYsLNGRQPP activity, induced; intracellular localization; activity, inhibited; phosphorylation carcinogenesis, induced; cell motility, induced; transcription, induced 12351631; 31730483; 9072970 3 6 1 phosphorylation creates predicted overlapping GSK3B phosphorylation sites; multiple sites mutatnt +MOB1A MOB1A Protein kinase, regulatory subunit Q9H8S9 55233 2p13.1 human T35-p 3212769 LLKHAEAtLGSGNLR Mob1_phocein activity, induced; molecular association, regulation; protein conformation; phosphorylation cell cycle regulation; carcinogenesis, inhibited; cell growth, inhibited; apoptosis, induced; signaling pathway regulation NDR1(INDUCES); MST2(INDUCES); LATS1(INDUCES); MST1(DISRUPTS) 26108669; 28373297; 32513747; 36622276; 37319316; 37392812 13 45 34 +ING1 ING1 iso2 Tumor suppressor Q9UK53-2 3621 13q34 human K193-sm 34483100 KKKRSKAkAEREASP protein degradation; molecular association, regulation cell differentiation, induced; transcription, altered HIF1A(DISRUPTS) DNA(DISRUPTS) 24903338; 25611387 2 0 0 induces HIF1 degradation +Fyn Fyn EC 2.7.10.2; KINASE; Kinase, protein; Oncoprotein; Protein kinase, TK; Protein kinase, tyrosine (non-receptor) P39688 14360 10 B1|10 20.51 cM mouse Y420-p 447882 RLIEDNEyTARQGAK PK_Tyr_Ser-Thr enzymatic activity, induced 12545173; 16339530; 23602477 31 94 3048 +Apbb1 Fe65 Adaptor/scaffold; Apoptosis; Transcription regulation P46933 29722 1q32 rat S611-p 2035401 ECRVRFLsFLAVGRD PID intracellular localization 18304449 2 0 0 +H2AX H2AX DNA repair, damage; DNA-binding; Helicase P16104 3014 11q23.3 human K119-ub 3945267 QAVLLPKkTSATVGP Histone_H2A_C protein degradation; molecular association, regulation; intracellular localization; phosphorylation cell cycle regulation; DNA repair, induced ATM(INDUCES); UBE2T(INDUCES) 19305155; 21676867; 21690091; 31533041; 33087136 7 13 156 ATM recruitment, H2AX S139 phosphorylation ; CHK1 phosphorylation and activation, cell cycle arrest, the DNA damage response and radioresistance +MAVS MAVS Adaptor/scaffold; Membrane protein, integral Q7Z434 57506 20p13 human S233-p 3204105 SFQPLARsTPRASRL molecular association, regulation PLK1(INDUCES) 19546225 1 4 0 +Tfcp2l1 TFCP2L1 DNA-binding Q3UNW5 81879 1|1 E2.3 mouse T177-p 38489957 HCISTEFtPRKHGGE CP2 molecular association, regulation cell cycle regulation; carcinogenesis, induced; cell growth, inhibited; cell differentiation, induced; transcription, altered DNA(INDUCES) 31709755 1 1 1 induces binding to target genes, inhibits cell death +TRIM71 TRIM71 UBIQUITIN LIGASE; Ubiquitin conjugating system; Ubiquitin ligase Q2Q1W2 131405 3p22.3 human S3-p 18914372 _____MAsFPETDFQ protein stabilization; molecular association, regulation; ubiquitination carcinogenesis, inhibited UBE1(DISRUPTS); UBE2D3(DISRUPTS); ubiquitin(DISRUPTS) 31160797 1 2 0 inhibits ubiquitination +BRCA1 BRCA1 EC 6.3.2.-; Nuclear receptor co-regulator; Transcription, coactivator/corepressor; Tumor suppressor; UBIQUITIN LIGASE; Ubiquitin conjugating system; Ubiquitin ligase P38398 672 17q21.31 human S1164-p 36135579 GEIKEDTsFAENDIK intracellular localization DNA repair, induced 26745677 2 2 0 important for foci formation following DSB +LMO2 LMO2 Adaptor/scaffold; Oncoprotein P25791 4005 11p13 human K78-ac 1879723003 LYYKLGRkLCRRDYL molecular association, regulation; activity, inhibited cell differentiation, inhibited; cell growth, inhibited; apoptosis, induced; transcription, inhibited LDB1(DISRUPTS) 31366618 1 0 0 inactivation of TAL-1 complex, LMO2 is deacetylated by PBEF/SIRT2 during the early stages of hematopoietic differentiation +Tbx21 TBX21 DNA-binding; Transcription factor Q9JKD8 57765 11|11 D mouse Y525-p 458297 KETEGQFyNYFPN__ molecular association, regulation transcription, altered GATA3(INDUCES) 15662016 1 0 0 +DEPTOR DEPTOR Apoptosis Q8TB45 64798 8q24.12 human Y289-p 1875073002 SSCGSSGyFSSSPTL protein stabilization; molecular association, regulation; ubiquitination; phosphorylation cytoskeletal reorganization mTOR(DISRUPTS) 34634301 1 0 0 inhibits ubiquitination, induces AKT phosphorylation, decrease mTOR inhibitory activity +HIPK2 HIPK2 EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, CMGC; Protein kinase, Ser/Thr (non-receptor) Q9H2X6 28996 7q34 human K1191-ub 3059901 GYPLSPAkVNQYPYI protein degradation; ubiquitination 17349959; 18536714 2 0 0 +Tiam1 TIAM1 GEF; GEF, Rac/Rho; Motility/polarity/chemotaxis; Oncoprotein Q60610 21844 16 C3.3|16 51.5 cM mouse S60-p 11485305 EVSTRSSsTPSIPQS protein degradation; molecular association, regulation 14-3-3 zeta(INDUCES) 19899799 2 1 0 +POU5F1 Oct4 DNA-binding; Transcription factor Q01860 5460 6p21.33 human K156-m1 57951801 FAKLLKQkRITLGYT Pou protein stabilization; molecular association, regulation transcription, induced SOX2(INDUCES) 27369080 1 1 0 +RIN1 Rin1 GEF; GEF, Rab Q13671 9610 11q13.2 human S291-p 1244499 CQLLRREsSVGYRVP molecular association, regulation cell motility, inhibited HRas(INDUCES) 27137893 1 4 19 +Prkaa1 AMPKA1 Autophagy; EC 2.7.11.1; EC 2.7.11.26; EC 2.7.11.27; EC 2.7.11.31; KINASE; Kinase, protein; Protein kinase, CAMK; Protein kinase, Ser/Thr (non-receptor) P54645 65248 2q16 rat T183-p 448786 SDGEFLRtSCGSPNY Pkinase protein stabilization; molecular association, regulation; enzymatic activity, induced 14-3-3 beta(INDUCES); 14-3-3 sigma(INDUCES); 14-3-3 theta(INDUCES); 14-3-3 zeta(INDUCES); 14-3-3 epsilon(INDUCES); 14-3-3 gamma(INDUCES); 14-3-3 eta(INDUCES) 10642499; 12456889; 12764152; 17032173; 17082196; 17147517; 17253964; 20146253; 9305909 228 16 33 +Adcy6 ADCY6 Adenylyl cyclase; EC 4.6.1.1; Lyase; Membrane protein, integral; Membrane protein, multi-pass; Nucleotide Metabolism - purine; Transporter; Transporter, aquaporin family AAA40678 25289 7q36 rat S608-p 467271 AFSRTKDsKAFRQMG Adcy_cons_dom enzymatic activity, induced 11327830 1 0 0 +ACBD5 ACBD5 iso2 Lipid-binding; Membrane protein, integral Q5T8D3-2 91452 10p12.1 human S261-p 1876128610 IQHLTSDsDSEVYCD molecular association, regulation; phosphorylation VAPB(INDUCES) 35019937 1 1 0 induces phosphorylation at S269 +Cebpa C/EBP-alpha DNA-binding; Transcription factor P53566 12606 7 B2|7 21.02 cM mouse S21-p 448308 PMSSHLQsPPHAPSN activity, induced transcription, altered 18408001 10 1 0 impaired glucose uptake and Glut 4 expression +GTF2I GTF2I DNA-binding; Transcription, coactivator/corepressor P78347 2969 7q11.23 human S784-p 457075 GVPFRRPsTFGIPRL GTF2I transcription, induced 12082086 2 14 266 +JUN Jun Oncoprotein; Transcription factor P05412 3725 1p32.1 human T286-p 17737605 RLEEKVKtLKAQNSE bZIP_1 carcinogenesis, altered; cell growth, altered 21177766 1 0 1 +Scnn1g ENaC-gamma Channel, sodium; Membrane protein, integral; Membrane protein, multi-pass; Transporter, ion channel P37091 24768 1q36 rat K8-ub 486251 MAPGEKIkAKIKKNL receptor recycling, inhibited; protein degradation; intracellular localization 9351815 1 0 0 +Syngap1 SynGAP iso3 GAP; GAP, Ras Q9QUH6-3 192117 20p12 rat S326-p 4792707 GSGGGGGsGGGSGGK molecular association, regulation; intracellular localization HRas(INDUCES) 21382555 1 1 0 +RPS6KA1 p90RSK EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, AGC; Protein kinase, Ser/Thr (non-receptor); Translation Q15418 6195 1p36.11 human S363-p 447989 TSRTPKDsPGIPPSA Pkinase_C enzymatic activity, induced 23708659 42 47 4 +GCM1 GCM1 DNA-binding; Transcription factor Q9NP62 8521 6p12.1 human K409-ac 460589 SLPSKSSkWDFEEEM protein stabilization; ubiquitination transcription, induced 16166624 1 0 0 inhibits ubiquitination +EIF5A EIF5A Translation; Translation initiation P63241 1984 17p13.1 human K47-ac 458947 IVEMSTSkTGKHGHA intracellular localization 7578077 2 7 6 excluded from nucleus and localized in cytoplasm, reduces the rate of hypucine synthesis +BRCA1 BRCA1 EC 6.3.2.-; Nuclear receptor co-regulator; Transcription, coactivator/corepressor; Tumor suppressor; UBIQUITIN LIGASE; Ubiquitin conjugating system; Ubiquitin ligase P38398 672 17q21.31 human S694-p 4787521 QTSKRHDsDTFPELK protein stabilization 20085797 1 19 3 +KLF13 KLF13 C2H2-type zinc finger protein; DNA-binding Q9Y2Y9 51621 15q13.3 human K166-ac 460598 DLESPQRkHKCHYAG molecular association, regulation DNA(DISRUPTS) 12758070 1 0 0 +Exoc8 EXOC8 Vesicle O54924 245709 19q12 rat S31-p 40510667 VKQLSQQsDGDRDLQ Vps51 molecular association, regulation exocytosis, inhibited Sec5(DISRUPTS); EXOC8(DISRUPTS) 28325821 1 2 1 +NT5C2 NT5C2 Cofactor and Vitamin Metabolism - nicotinate and nicotinamide; EC 3.1.3.5; Hydrolase; Nucleotide Metabolism - purine; Nucleotide Metabolism - pyrimidine P49902 22978 10q24.32-q24.33 human S502-p 3191299 VDINEMEsPLATRNR protein conformation; enzymatic activity, induced carcinogenesis, induced 35984649 1 8 0 +ADRA1B ADRA1B GPCR, family 1; Membrane protein, integral; Membrane protein, multi-pass; Receptor, GPCR P18841 101843941 hamster S404-p 451004 RSQSRKDsLDDSGSC receptor desensitization, altered 9353340 1 4 3 +NANOG NANOG Cell development/differentiation; DNA-binding; Transcription factor Q9H9S0 79923 12p13.31 human S79-p 28070708 PKGKQPTsAEKSVAK transcription, induced 23708658 1 2 0 +Ptpn6 SHP-1 EC 3.1.3.48; Motility/polarity/chemotaxis; PHOSPHATASE; Protein phosphatase, tyrosine (non-receptor) P29351 15170 6 F2|6 59.17 cM mouse S591-p 454019 DKEKNKGsLKRK___ protein processing; intracellular localization; enzymatic activity, inhibited 17575265; 18617527; 20351292; 28811476 9 2 15 +ITGB1 ITGB1 Cell adhesion; Cell surface; Membrane protein, integral; Motility/polarity/chemotaxis; Receptor, misc. P05556 3688 10p11.22 human S785-p 452040 GENPIYKsAVTTVVN Integrin_b_cyt cytoskeletal reorganization 20926684 5 11 17 +Nlgn2 NLGN2 Membrane protein, integral Q62888 117096 10q24 rat S714-p 487169 ELRCRRLsPPGGSGS receptor internalization, induced; intracellular localization; activity, inhibited neural plasticity 27805570; 35727864 3 9 0 +Mafa MAFA DNA-binding; Oncoprotein; Transcription factor; Tumor suppressor Q8CF90 378435 15|15 D3 mouse S65-p 5403102 PCSSVPSsPSFCAPS protein degradation; molecular association, regulation; ubiquitination; phosphorylation transcription, induced; transcription, inhibited MAFA(INDUCES); PSME3(INDUCES) DNA(NOT_REPORTED) 19004825; 20208071; 21646385; 34644565 9 0 0 +H3-3A H3 DNA-binding Q71LE2 396970 pig K27-m3 1308913 LATKAARkSAPSTGG Histone cell differentiation, inhibited; transcription, inhibited 19536841; 32893712; 34943981 195 24 3 mesenchymal stem/stroma cells of obese pigs had suppressed transcription compared to lean pigs; tributyrin treatment: positive regulators of cell proliferation were enriched for H3K27me3 ; low levels of trimethylated H3K27 detected +MKNK1 Mnk1 iso2 EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, CAMK; Protein kinase, Ser/Thr (non-receptor); Translation Q9BUB5-2 8569 1p33 human T214-p 447622 ITTPELTtPCGSAEY Pkinase intracellular localization; enzymatic activity, induced 17590453 13 1 0 Leaves nucleus to cytoplasm upon phosphorylation. +ZFP36L1 BRF1 Transcription factor Q07352 677 14q24.1 human S92-p 470147 RFRDRSFsEGGERLL Tis11B_N protein stabilization; molecular association, regulation; intracellular localization cell growth, inhibited; transcription, altered; RNA stability, altered 14-3-3 beta(INDUCES) 15538381; 17030608; 18326031; 26280535 4 20 1 for its physiological effect phosphorylation of this site cooperates with phosphorylation of S90 and S203; inhibits BRF1-dependent AMD ( ARE-mediated mRNA decay); senescence-associated secretory phenotype (SASP) +Mapt Tau ACETYLTRANSFERASE; Acetyltransferase; Cytoskeletal P10637 17762 11 67.79 cM|11 E1 mouse T523-p 449079 KKVAVVRtPPKSPSA receptor internalization, induced; intracellular localization; phosphorylation neural plasticity; transcription, induced 24653715; 27834631; 33428131; 34158075; 34551296; 36186135 149 48 14 +HOXA11 HOXA11 DNA-binding; Transcription factor P31270 3207 7p15.2 human T119-p 55571506 ANVYHHPtPAVSSNF DUF3528 molecular association, regulation transcription, induced CBP(INDUCES) 27239043 1 1 0 +Idh2 IDH2 Carbohydrate Metabolism - citrate (TCA) cycle; EC 1.1.1.42; Mitochondrial; Other Amino Acids Metabolism - glutathione; Oxidoreductase P54071 269951 7 D2|7 45.43 cM mouse K413-ac 1204122 VESGAMTkDLAGCIH Iso_dh enzymatic activity, inhibited 36654268 6 3 5 +HRAS HRas G protein; G protein, monomeric; G protein, monomeric, Ras; Motility/polarity/chemotaxis; Oncoprotein P01112 3265 11p15.5 human K117-ub 31914117 PMVLVGNkCDLAART Ras enzymatic activity, induced 24247240 1 1 0 +YWHAE 14-3-3 epsilon Adaptor/scaffold P62258 7531 17p13.3 human K123-ac 11315832 ESKVFYYkMKGDYHR 14-3-3 molecular association, regulation SFRS6(DISRUPTS); PLEKHQ1(DISRUPTS); SFRS4(DISRUPTS); DOK3(DISRUPTS); TSC2(DISRUPTS); ARAF(DISRUPTS); LARP(DISRUPTS); SRm300(DISRUPTS); SF2(DISRUPTS); TSC22D1(DISRUPTS); GAB2(DISRUPTS); RAF1(DISRUPTS); VASP(DISRUPTS); HDAC4(DISRUPTS); TRA2B(DISRUPTS); GBF1(DISRUPTS) 19608861 0 2 5 +Ptk2 FAK iso2 EC 2.7.10.2; KINASE; Kinase, protein; Protein kinase, TK; Protein kinase, tyrosine (non-receptor) P34152-2 14083 15 D3|15 33.94 cM mouse S763-p 450196 SSEGFYPsPQHMVQT molecular association, regulation cell cycle regulation; cell differentiation, altered; carcinogenesis, induced; cell growth, altered DNAI1(INDUCES) 19201755 5 1 0 S770 FAK phosphorylation regulates centrosomes during mitosis, proliferation, tublogenesis, and tumor angiogenesis. +Cttn Cortactin Actin-binding; Cytoskeletal; Motility/polarity/chemotaxis Q60598 13043 7|7 F5 mouse Y421-p 447702 RPPSSPIyEDAAPFK molecular association, regulation; intracellular localization cell cycle regulation; cell motility, induced; cell motility, altered; cytoskeletal reorganization MTUS2(DISRUPTS); Arg(INDUCES); VAV2(INDUCES); Abl(INDUCES); FAK(DISRUPTS); smMLCK(INDUCES); N-WASP(INDUCES) 12408982; 15169891; 17343955; 18515860; 22078467; 22952866; 24891505; 27340123; 27451391; 28885660; 34439396 47 62 745 Tyr to Phe mutation of this site prevents FAK-mediated FA turnover +NINL Nlp Cell cycle regulation; Microtubule-binding Q9Y2I6 22981 20p11.21 human K495-ub 486278 EKLTLALkENSRLQK protein degradation 17403670 1 0 0 +KHDRBS1 KHDRBS1 RNA-binding Q07666 10657 1p35.2 human R45-m2 476768 PPLPHRSrGGGGGSR intracellular localization 12529443 1 3 0 +XRCC6 Ku70 DNA repair, damage; DNA-binding; EC 3.6.4.-; EC 4.2.99.-; Helicase; Nuclear receptor co-regulator; RNA-binding P12956 2547 22q13.2 human S155-p 21691607 WVCANLFsDVQFKMS Ku_N molecular association, regulation; phosphorylation cell cycle regulation; apoptosis, induced AurB(INDUCES); TRIP12(INDUCES) 22037767; 27849008; 37108203 3 0 0 +P2RY2 P2Y2 GPCR, family 1; Membrane protein, integral; Membrane protein, multi-pass; Receptor, GPCR; Receptor, misc. P41231 5029 11q13.4 human S243-p 2909200 LPRAKRKsVRTIAVV 7tm_1 receptor desensitization, altered; intracellular localization 16311903 2 0 0 +MAP3K5 ASK1 EC 2.7.11.25; KINASE; Kinase, protein; Protein kinase, STE; Protein kinase, Ser/Thr (non-receptor) Q99683 4217 6q23.3 human R89-me 54227301 SSVGGGSrRTTVAYV molecular association, regulation; phosphorylation Akt1(INDUCES) 26912789 1 1 0 methylation of ASK1 at Arg89 promotes the phosphorylation of ASK1 at S83 +PIK3R1 PIK3R1 KINASE; Kinase, lipid; Motility/polarity/chemotaxis P27986 5295 5q13.1 human S154-p 7445250 STLYRTQsSSNLAEL RhoGAP activity, induced; molecular association, regulation; intracellular localization cell motility, inhibited PTEN(INDUCES) 23129748 3 8 0 neutrophil migration regulation +Snap25 SNAP-25 Vesicle P60879 20614 2 F3|2 67.56 cM mouse T138-p 449875 GGFIRRVtNDARENE SNAP-25 molecular association, regulation exocytosis, inhibited STX1A(DISRUPTS) 28486561 7 5 3 +TRIM65 TRIM65 Ubiquitin conjugating system Q6PJ69 201292 17q25.1 human S172-p 1871608300 QSSQIQNsACILASW carcinogenesis, inhibited; signaling pathway regulation 31332286 1 1 0 dephosphorylated form (6A mutant) contributes to TRIM65 function in tumor progression +Nefm NFM Cytoskeletal P08553 18040 14|14 D1 mouse S605-p 451836 EKPEKAKsPMPKSPV cytoskeletal reorganization 19193875 4 20 19 slightly altered axoplasmic organization in 7S/A mice mutant +AMOTL2 AMOTL2 Cell adhesion Q9Y2J4 51421 3q22.2 human Y107-p 15561222 KGEELPTyEEAKAHS molecular association, regulation signaling pathway regulation Src(INDUCES) 21937427 1 1 0 activation of Ras/Raf/Erk pathway +BDKRB2 BKR2 GPCR, family 1; Membrane protein, integral; Membrane protein, multi-pass; Receptor, GPCR P30411 624 14q32.2 human Y177-p 457134 GVRWAKLySLVIWGC 7tm_1; TM activity, induced; phosphorylation 16226010 1 0 1 this increases ERK activation when stimulated with EGF+isoproterenol+bradykinin as compared to the WT BKR2.; Mutation of both tyrosines to phenylalanines prevents Gi protein-mediated cAMP accumulation induced by bradykinin +CTTN Cortactin Actin-binding; Cytoskeletal; Motility/polarity/chemotaxis Q14247 2017 11q13.3 human Y470-p 447703 AYATEAVyESAEAPG molecular association, regulation; receptor recycling, induced cell motility, induced; cell adhesion, altered; cytoskeletal reorganization N-WASP(INDUCES) 15056655; 24188565; 25077552; 29133485; 9748248 32 3 10 invadopodia formation; Tyrosine phosphorylation is necessary for enhanced S1P barrier enhancement. ; ECM invasion as well as transwell and 2D migration; Previous work by the authors showed that src attenuates the actin cross-linking activity of cortactin. These studies show that transfection with a cortactin mutant (F421/F470/F486) impairs the motility of endothelial cells. +MAPKAP1 Sin1 Adaptor/scaffold Q9BPZ7 79109 9q33.3 human S128-p 3830292 KSLFEKKsLKEKPPI SIN1 intracellular localization signaling pathway regulation 30837283 1 0 22 +BAK1 BAK1 Apoptosis; Endoplasmic reticulum; Membrane protein, integral; Mitochondrial Q16611 578 6p21.31 human Y108-p 15794303 QPTAENAyEYFTKIA Bcl-2 protein conformation; activity, inhibited apoptosis, altered; apoptosis, inhibited 20959805; 25649765 3 1 0 +PAPOLA PAP-alpha EC 2.7.7.19; RNA processing; RNA splicing; Transferase P51003 10914 14q32.2 human K740-ac 483064 PVIKNSIkLRLNR__ protein stabilization; molecular association, regulation; enzymatic activity, inhibited; intracellular localization CPSF6(DISRUPTS); CFIM25(DISRUPTS) 17172643; 18281463 2 1 0 +TRIP10 TRIP10 iso3 Adaptor/scaffold; Motility/polarity/chemotaxis; Nuclear receptor co-regulator Q15642-3 9322 19p13.3 human Y471-p 480709 ESQDTPIyTEFDEDF intracellular localization carcinogenesis, altered; cytoskeletal reorganization 21525036 1 0 2 alters TRIP10 invadopodia-suppressive activity +TP63 p63 DNA-binding; Transcription factor Q9H3D4 8626 3q28 human K676-sm 3617601 RNKQQRIkEEGE___ protein degradation transcription, inhibited 15611636 2 0 0 +STAT6 STAT6 DNA-binding; Transcription factor P42226 6778 12q13.3 human S407-p 21561700 PIQLQALsLPLVVIV STAT_bind molecular association, regulation; intracellular localization; phosphorylation transcription, induced; signaling pathway regulation STAT6(INDUCES) 22000020 1 0 0 induces phosphorylation of Y641 and regulates cytokine signaling +UHRF1 UHRF1 DNA-binding; EC 6.3.2.-; EC 6.3.2.19; Ligase; Transcription factor; UBIQUITIN LIGASE; Ubiquitin conjugating system; Ubiquitin ligase Q96T88 29128 19p13.3 human S298-p 2902206 DNPMRRKsGPSCKHC molecular association, regulation; protein conformation cell cycle regulation ATRX(INDUCES); UHRF1(DISRUPTS) 32428527 3 1 0 interaction with apo-TTD and the linker domain disrupted +MAPK3 ERK1 EC 2.7.11.24; KINASE; Kinase, protein; Protein kinase, CMGC; Protein kinase, Ser/Thr (non-receptor) P27361 5595 16p11.2 human T207-p 3949243 FLTEYVAtRWYRAPE Pkinase enzymatic activity, inhibited 26823016 2 13 31 +TTK TTK Cancer Testis Antigen (CTA); EC 2.7.12.1; KINASE; Kinase, protein; Protein kinase, Other; Protein kinase, dual-specificity (non-receptor) P33981 7272 6q14.1 human T12-p 13194901 DLSGRELtIDSIMNK intracellular localization; enzymatic activity, induced cell cycle regulation 18923149; 25265012; 26119734; 36395767 6 2 1 autophosphorylation of this site is required for release TTK from kinetochore; causes decreased kinetochore localization of BubR1 and Mad2. +TERF2 TRF2 DNA repair, damage; DNA-binding Q15554 7014 16q22.1 human R59-me 10338216 GSGRAAGrRASRSSG cell cycle regulation; cell growth, altered 19596784 1 0 0 +EPHA3 EphA3 EC 2.7.10.1; KINASE; Kinase, protein; Membrane protein, integral; Protein kinase, TK; Protein kinase, tyrosine (receptor) P29320 2042 3p11.1 human Y602-p 449913 TYVDPHTyEDPTQAV EphA2_TM molecular association, regulation; enzymatic activity, induced cytoskeletal reorganization; cell adhesion, altered CRK(INDUCES) 11870224; 18547520 3 6 31 +CAB2 CACNB2 Channel, calcium P54288 100009277 rabbit S522-p 486359 SGTSRGLsRQETFDS activity, inhibited 17626895; 20937253 3 2 5 +RUNX2 AML3 DNA-binding; Transcription factor Q13950 860 6p21.1 human S196-p 27728401 GRSGRGKsFTLTITV Runt molecular association, regulation transcription, induced DNA(INDUCES) 23389849 1 0 0 induction of MMP3 and MMP9 transcription, invasion of breast cancer cells +LRRK2 LRRK2 EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, Ser/Thr (non-receptor); Protein kinase, TKL Q5S007 120892 12q12 human T1491-p 10426326 DYHFVNAtEESDALA molecular association, regulation TUBB(DISRUPTS) 24275654 10 5 0 +CRMP1 CRMP-1 Cell development/differentiation; Cytoskeletal; Hydrolase Q14194 1400 4p16.2 human T509-p 454314 PVYEVPAtPKYATPA cytoskeletal reorganization 18003833 6 18 7 Phosphorylation induces increased density of synaptic clusters and neurite projection. +IRF7 IRF7 DNA-binding; Transcription factor Q92985 3665 11p15.5 human K92-ac 458962 TAERAGWkTNFRCAL IRF molecular association, regulation DNA(DISRUPTS) 12374802 1 0 0 +Mcm3 MCM3 DNA replication; EC 3.6.4.12 P25206 17215 1|1 A4 mouse S725-p 475061 HTPKTDDsQEKTDDS intracellular localization 17244605 1 4 0 Preferentially localized to the soluble nucleoplasmic fraction. +Notch1 Notch 1 Membrane protein, integral; Motility/polarity/chemotaxis; Oncoprotein; Receptor, misc.; Transcription factor Q01705 18128 2 A3|2 18.91 cM mouse R2303-m2 56852200 GQCEWLPrLQNGMVP activity, induced; protein degradation; ubiquitination transcription, induced 25805888 1 1 0 +Tardbp TDP-43 RNA-binding Q921F2 230908 4|4 E2 mouse S409-p 3084616 GSSMDSKsSGWGM__ ubiquitination apoptosis, induced DROSHA(DISRUPTS); hnRNP P2(DISRUPTS) 23840565; 26102026 54 4 0 Phosphorylated, ubiqitinated protein forms insoluble aggregates.; disrupts interaction between Drosha and FUS +TFEB TFEB DNA-binding; Transcription factor P19484 7942 6p21.1 human S211-p 25529700 LVGVTSSsCPADLTQ activity, induced; molecular association, regulation; intracellular localization; activity, inhibited; phosphorylation carcinogenesis, induced; exocytosis, induced; cell motility, induced; apoptosis, inhibited; autophagy, inhibited; transcription, inhibited; cell growth, altered 14-3-3 beta(INDUCES); mTOR(INDUCES); 14-3-3 theta(INDUCES); 14-3-3 zeta(INDUCES); 14-3-3 epsilon(INDUCES); 14-3-3 gamma(INDUCES); CHIP(INDUCES) 22576015; 22692423; 25561726; 26813791; 28055300; 28754656; 29507340; 29945972; 34405859; 35020443; 36436593; 36970883 22 3 0 +Dmd dystrophin Cytoskeletal; Motility/polarity/chemotaxis P11531 13405 X C1|X 38.38 cM mouse S3059-p 35542205 GPWERAIsPNKVPYY WW molecular association, regulation DAG1(INDUCES) 33729835 2 1 0 regulates protection against inflammation-induced muscle wasting +ARHGDIB RhoGDI beta Cell adhesion; G protein regulator, misc.; Motility/polarity/chemotaxis P52566 397 12p12.3 human S31-p 4933709 YKPPPQKsLKELQEM Rho_GDI molecular association, regulation; activity, inhibited CDC42(DISRUPTS); RAC1(DISRUPTS) 22469974; 31075185 2 2 34 +Gsk3b GSK3B EC 2.7.11.1; EC 2.7.11.26; KINASE; Kinase, protein; Protein kinase, CMGC; Protein kinase, Ser/Thr (non-receptor) P18266 84027 11q21 rat K205-ac 27738300 LCDFGSAkQLVRGEP Pkinase transcription, induced 23292070 2 0 0 +Nlrp3 NLRP3 Inhibitor Q8R4B8 216799 11|11 B1.3 mouse S803-p 1877558200 KLVELDLsDNALGDF LRR_6 molecular association, regulation NEK7(DISRUPTS); PYCARD(DISRUPTS) 34615873 1 1 0 +FUS hnRNP P2 DNA-binding; Nuclear receptor co-regulator; Oncoprotein; RNA splicing; RNA-binding; SUMO LIGASE P35637 2521 16p11.2 human K510-ac 36293641 RGGFGPGkMDSRGEH molecular association, regulation; intracellular localization KPNB2(DISRUPTS) 32691043 1 2 2 formation of stress granule-like inclusions +YAP1 YAP1 Oncoprotein; Transcription, coactivator/corepressor P46937 10413 11q22.1 human K494-ub 1880099301 ESVLAATkLDKESFL protein degradation carcinogenesis, altered 36271031 1 0 0 +Irs1 IRS1 Adaptor/scaffold; Motility/polarity/chemotaxis P35570 25467 9q34 rat S635-p 447507 YMPMSPKsVSAPQQI molecular association, regulation PIK3R1(DISRUPTS) 16354680 35 4 0 +BCL2L11 BIM Apoptosis O43521 10018 2q13 human S69-p 449330 GPLAPPAsPGPFATR protein degradation; molecular association, regulation apoptosis, altered; apoptosis, inhibited; cell adhesion, altered; transcription, altered Bcl-xL(DISRUPTS); MCL1(DISRUPTS) 14555991; 15486195; 17525735; 18246127; 25915848 23 1 1 tyrosine kinase inhibitor resistance +RPS6KA5 MSK1 EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, AGC; Protein kinase, Ser/Thr (non-receptor) O75582 9252 14q32.11 human S212-p 448214 DETERAYsFCGTIEY Pkinase enzymatic activity, induced 15568999 2 6 9 +AMPH amphiphysin Vesicle P49418 273 7p14.1 human T350-p 469996 PEVKKEEtLLDLDFD molecular association, regulation CLTC(DISRUPTS) 16945112 1 0 0 +Panx3 PANX3 Cell adhesion; Membrane protein, integral; Membrane protein, multi-pass Q8CEG0 208098 9|9 A4 mouse S68-p 1869686803 GSPISCFsPSNFSVR Innexin activity, induced; intracellular localization; protein conformation cell differentiation, induced; signaling pathway regulation 31822768 1 0 0 osteoblast differentiation +Rag1 RAG1 DNA-binding; EC 3.1.-.-; EC 6.3.2.-; EC 6.3.2.19; Ligase; UBIQUITIN LIGASE; Ubiquitin conjugating system; Ubiquitin ligase P15919 19373 2 E2|2 53.88 cM mouse S528-p 28076402 PPLKNVSsRTDVGII RAG1 activity, induced 23716691 1 0 0 Phosphorylation at S528 activates V(D)J recombination. +Wasl N-WASP Adaptor/scaffold; Motility/polarity/chemotaxis Q91YD9 73178 6|6 A3.1 mouse Y253-p 450253 RETSKVIyDFIEKTG PBD activity, induced; molecular association, regulation; intracellular localization cytoskeletal reorganization KPNA1(DISRUPTS) 14676198; 24223520 9 65 1373 +Hspb1 HSP27 Chaperone; Heat shock protein; Motility/polarity/chemotaxis; SUMO LIGASE; SUMO ligase P42930 24471 12q12 rat S86-p 448403 RALNRQLsSGVSEIR intracellular localization; enzymatic activity, induced cytoskeletal reorganization 24914207; 33557752; 36260112 78 104 289 Actin polymerization induced +URI1 RMP Transcription, coactivator/corepressor O94763 8725 19q12 human S372-p 1028301 AKRKRKNsTGSGHSA O-GlcNAc glycosylation; molecular association, regulation; phosphorylation carcinogenesis, inhibited; cell growth, inhibited; apoptosis, induced; apoptosis, inhibited; signaling pathway regulation PPP1CC(DISRUPTS) 17936702; 21397856; 27505673 3 23 16 increased S372 phosphorylation induces disruption of complexes ; inhibits S6K1 and BAD phosphorylation, regulates S6K1/BAD signaling pathway; S372 phosphorylation inversely correlated with O-GlcNAcylation +DRD3 DRD3 GPCR, family 1; Membrane protein, integral; Membrane protein, multi-pass; Receptor, GPCR P35462 1814 3q13.31 human T142-p 1184590200 PVHYQHGtGQSSCRR 7tm_1 protein degradation; molecular association, regulation endocytosis, induced GRK2(DISRUPTS) 29885323 1 0 0 inhibits receptor signaling +PRKCD PKCD EC 2.7.11.13; KINASE; Kinase, protein; Nuclear receptor co-regulator; Protein kinase, AGC; Protein kinase, Ser/Thr (non-receptor); Protein kinase, tyrosine (non-receptor); Tumor suppressor Q05655 5580 3p21.1 human Y334-p 450077 MQDNSGTyGKIWEGS molecular association, regulation; enzymatic activity, induced apoptosis, induced Src(INDUCES) 17658731; 28784722 13 25 532 Y334 phosphorylation increases clevage of PKCD into active catalytic domain. ; DKD-507A activity activity is rescued by Src-dependent Y334 phosphorylation +FNIP1 FNIP1 Q8TF40 96459 5q31.1 human S946-p 4734332 SDSALGDsESEDTGH protein stabilization; molecular association, regulation signaling pathway regulation HSP90A(INDUCES) DNA(INDUCES) 30699359 1 10 0 +RECQL4 RECQL4 EC 3.6.4.12; Helicase O94761 9401 8q24.3 human T139-p 1869193203 RASSKAStPKPPGTG molecular association, regulation WDHD1(INDUCES); GINS4(INDUCES) 31519754 1 0 0 induces activation of replication origin +NOX5 NOX5 EC 1.6.3.-; Membrane protein, integral; Membrane protein, multi-pass; Oxidoreductase Q96PH1 79400 15q23 human Y476-p 1869973807 FHYRPGDyLYLNIPT FAD_binding_8 signaling pathway regulation 32792487 1 0 0 activation of Src, Pyk2-mediated phosphorylation of Nox5 +PCNT PCNT Cell cycle regulation O95613 5116 21q22.3 human S1235-p 25617500 MSSVAEIsSHMRESF cytoskeletal reorganization 22184200; 24466316 2 0 0 important for spindle formation and centrosomal microtubule nucleation and the recruitment of the PCM proteins for centrosome maturation in mitosis; centrosome maturation and bipolar spindle formation during mitosis +TRPV5 TRPV5 Channel, cation; Membrane protein, integral; Membrane protein, multi-pass; Motility/polarity/chemotaxis Q9NQA5 56302 7q34 human S144-p 27115700 LTRRASVsARATGTA Ank_2 activity, inhibited 23024298 1 0 0 S144 phosphorylation is necessary for plasmin inhibition of channel Ca++ currents. +RIPK3 RIPK3 EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, Ser/Thr (non-receptor); Protein kinase, TKL Q9Y572 11035 14q12 human S227-p 23003800 VELPTEPsLVYEAVC Pkinase molecular association, regulation; phosphorylation signaling pathway regulation MLKL(INDUCES) 22265413; 29883609; 35256774; 35739084 25 7 0 induces necrosis through the necrosis pathway +tpx2.L TPX2 Cell cycle regulation; Microtubule-binding Q6NUF4 398174 frog S291-p 31890658 KRKHEEAsDYVSTAE intracellular localization KPNB1(INDUCES) 29276125 1 1 0 accumulation of TPX2 at the prophase centrosome +MCL1 MCL1 Apoptosis; Channel, misc.; Inhibitor; Membrane protein, integral; Mitochondrial Q07820 4170 1q21.2 human K194-ub 10837355 REQATGAkDTKPMGR protein degradation 28522751 4 5 33 +PPP1R15A GADD34 Apoptosis; Cell cycle regulation; DNA repair, damage; Protein phosphatase, regulatory subunit; Translation initiation O75807 23645 19q13.33 human Y262-p 478288 SDPRSWEyRSGEASE protein degradation; phosphorylation apoptosis, induced; signaling pathway regulation 24092754 1 1 0 modulates endoplasmic reticulum stress signaling; inhibits EIF2 dephosphorylation +CASP7 CASP7 Apoptosis; EC 3.4.22.60; Endoplasmic reticulum; Mitochondrial; Protease P55210 840 10q25.3 human S239-p 20473607 WRSPGRGsWFVQALC Peptidase_C14 enzymatic activity, inhibited; activity, inhibited cell growth, induced; apoptosis, inhibited 21555521; 27889207 2 0 0 +CENPQ CENPQ Q7L2Z9 55166 6p12.3 human S249-p 3850352 LDILHNSsQMKSMST CENP-Q molecular association, regulation; intracellular localization DNA(DISRUPTS) 25670858 1 7 5 CENPQ phosphorylation promotes the delocalization of the PBIP1-CENPQ complex from kinetochores +KNL1 CASC5 Cancer Testis Antigen (CTA); Cell cycle regulation Q8NG31 57082 15q15.1 human S24-p 3829218 RPVRRRHsSILKPPR phosphorylation cell cycle regulation 25402682 4 3 7 +PCSK9 PCSK9 Cell development/differentiation; EC 3.4.21.-; Protease; Secreted; Secreted, signal peptide Q8NBP7 255738 1p32.3 human S47-p 2811403 ELVLALRsEEDGLAE activity, induced; protein degradation; protein processing exocytosis, induced 18498363; 31553664 2 5 0 stabilizes against cleavage of propeptide; LDL-receptor activity induced, LDLR degradation +Btg2 BTG2 Transcription factor Q04211 12227 1 E4|1 58.1 cM mouse S147-p 455911 QMMLGRSsPSKNYVM molecular association, regulation PIN1(INDUCES) 15788397 1 0 0 +MAVS MAVS Adaptor/scaffold; Membrane protein, integral Q7Z434 57506 20p13 human S330-gl 1872691000 PSKLPTSsKPPGAVP phosphorylation 31461653 1 1 0 positively regulates phosphorylation of S442 (data from MAVS 7A mutant) +SENP2 SENP2 DESUMOYLASE; EC 3.4.22.68; Protease; Sumo-specific protease Q9HC62 59343 3q27.2 human K447-sm 1878219601 TFFYPKLkSGGYQAV ubiquitination; activity, inhibited 31266997 1 0 0 LMP1 inhibited the ubiquitination of SENP2 +Klc1 KLC1 Microtubule-binding; Motor O88447 16593 12 F1|12 61.13 cM mouse T465-p 4948487 DSPTVTTtLKNLGAL TPR_10 molecular association, regulation JIP1(DISRUPTS) 29093025 1 2 0 regulates the velocity of transport of APP by kinesin-1 by modulating its interaction with JIP1 +PCNA PCNA Cell cycle regulation; DNA replication P12004 5111 20p12.3 human K248-me 1872852100 IADMGHLkYYLAPKI PCNA_C protein stabilization; molecular association, regulation; ubiquitination cell cycle regulation; carcinogenesis, induced; DNA repair, induced; cell growth, induced FEN1(INDUCES) 22556262 1 0 0 inhibits ubiquitination, regulates DNA replication +KAT5 Tip60 ACETYLTRANSFERASE; Acetyltransferase; EC 2.3.1.48; Nuclear receptor co-regulator; Nucleolus Q92993 10524 11q13.1 human K451-sm 1968601 ISEITSIkKEDVIST MOZ_SAS intracellular localization; enzymatic activity, induced DNA repair, induced 17704809 1 0 0 +BRIP1 BRIP1 EC 3.6.4.13; Helicase; Oncoprotein Q9BX63 83990 17q23.2 human T1133-p 5831623 EDESIYFtPELYDPE molecular association, regulation cell cycle regulation TOPBP1(INDUCES) 20159562 1 0 1 +NUMA1 NuMA-1 Cell cycle regulation; Motility/polarity/chemotaxis Q14980 4926 11q13.4 human S1883-p 31033004 YRPTTRSsARRSQAG cell growth, induced; apoptosis, inhibited 23097092 1 1 0 cell proliferation increased +DYRK4 DYRK4 EC 2.7.12.1; KINASE; Kinase, protein; Protein kinase, CMGC; Protein kinase, dual-specificity (non-receptor) Q9NR20 8798 12p13.32 human Y264-p 454665 EHQKVYTyIQSRFYR Pkinase phosphorylation; enzymatic activity, induced 21127067 1 40 1593 Peptide 285 phosphorylation +RAD52 RAD52 DNA repair, damage P43351 5893 12p13.33 human K412-sm 13258712 RKSQDMKkRKYDPS_ intracellular localization 20190268 1 1 0 +CDC6 CDC6 Cell cycle regulation Q99741 990 17q21.2 human K109-ac 8539500 LTIKSPSkRELAKVH intracellular localization cell cycle regulation 19343071 1 0 0 +NDEL1 NDEL1 Microtubule-binding; Protease Q9GZM8 81565 17p13.1 human S242-p 3685801 IPNGFGTsPLTPSAR NUDE_C molecular association, regulation; intracellular localization PAFAH1B1(INDUCES); DYNC1I1(INDUCES) 12556484; 37086789 3 4 1 +BRCA1 BRCA1 EC 6.3.2.-; Nuclear receptor co-regulator; Transcription, coactivator/corepressor; Tumor suppressor; UBIQUITIN LIGASE; Ubiquitin conjugating system; Ubiquitin ligase P38398 672 17q21.31 human S1387-p 455495 EDCSGLSsQSDILTT cell cycle regulation; DNA repair, altered 12183412; 25939603; 26320175; 34301763 9 0 0 +Nfatc2 NFAT1 DNA-binding; Transcription factor Q60591 18019 2 H3|2 88.91 cM mouse S270-p 447849 VAPLPAAsPQRSRSP transcription, inhibited 11030334 0 12 0 +MAP3K5 ASK1 EC 2.7.11.25; KINASE; Kinase, protein; Protein kinase, STE; Protein kinase, Ser/Thr (non-receptor) Q99683 4217 6q23.3 human K535-sm 12004432 TTEQPVAkQELVDFW MAP3K_TRAF_bd molecular association, regulation apoptosis, inhibited ASK1(DISRUPTS); SUMO1(INDUCES) 16142216 1 0 0 ASK1 is not sumoylated but SUMO1 interaction inhibits the oligomerization of ASK1 +GPR15 GPR15 GPCR, family 1; Membrane protein, integral; Membrane protein, multi-pass; Receptor, GPCR P49685 2838 3q11.2 human S359-p 17737600 RRRKRSVsL______ molecular association, regulation; protein processing; intracellular localization 14-3-3 beta(INDUCES); COPB1(DISRUPTS) 21189250 2 0 0 +Plin1 perilipin 1 Lipid-binding Q8CGN5 103968 7|7 D2 mouse S276-p 450081 QVVSRRQsEVRVPWL Perilipin molecular association, regulation HSL(INDUCES) 19717842 2 1 0 +Ctnnb1 CTNNB1 Actin-binding; Cell adhesion; Motility/polarity/chemotaxis; Nuclear receptor co-regulator; Oncoprotein; Transcription factor Q9WU82 84353 8q32 rat Y654-p 447585 RNEGVATyAAAVLFR intracellular localization 12123611; 33660049 32 2 20 regulates dissociation of adherent junctions +EGR1 EGR1 C2H2-type zinc finger protein; DNA-binding; Transcription factor P18146 1958 5q31.2 human S378-p 11421601 RICMRNFsRSDHLTT zf-C2H2 transcription, altered DNA(DISRUPTS) 8662759 1 0 0 +XRCC1 XRCC1 DNA repair, damage P18887 7515 19q13.31 human K260-ac 466090 EEKKTPSkPPAQLSP protein degradation 31043584 1 1 2 +CDKN1A p21Cip1 Cell cycle regulation; Inhibitor P38936 1026 6p21.2 human S153-p 456134 SMTDFYHsKRRLIFS molecular association, regulation; intracellular localization Calmodulin(DISRUPTS) 15851482; 16055744 2 1 0 S152 D mutation inhibts binding of CaM to p21. S152D disrupted stress fibers. Phosphorylation at S152 did not affect p21 binding to PCNA. ; Mutation GFP S152D showed an increase in cytoplasmic localization. S152D mutation showed decreased nuclear localization in both COS and NIH 3T3 cells in comparison to wild-type. +GATA1 GATA1 DNA-binding; Transcription factor P17678 396450 chicken K214-ac 459195 GIQTRNRkVSSKGKK molecular association, regulation; protein conformation cell differentiation, induced; transcription, induced DNA(INDUCES) 9859997 2 1 0 +MAD1L1 MAD1L1 Cell cycle regulation; Cytoskeletal Q9Y6D9 8379 7p22.3 human S610-p 334535801 ELKKQVEsAELKNQR MAD molecular association, regulation cell cycle regulation Mad2(INDUCES) 29162720 1 0 0 +GOLPH3 GOLPH3 Mitochondrial Q9H4A6 64083 5p13.3 human T148-p 31834910 KETQPPEtVQNWIEL GPP34 activity, induced; molecular association, regulation DNA repair, induced; signaling pathway regulation MYO18A(INDUCES) 24485452 1 1 0 DNA-PK/GOLPH3/MYO18A pathway, Increased phosphorylation leads to DNA-damage-induced Golgi dispersion +Pik3ap1 BCAP Adaptor/scaffold Q9EQ32 83490 19|19 C3 mouse Y445-p 448184 PGCDDELyESMAAFA molecular association, regulation cell differentiation, altered PIK3R1(INDUCES) 18025150 2 0 0 regulate Akt activation and B-cell differentiation through binding to PI3KR1 +MTOR mTOR Autophagy; EC 2.7.11.1; KINASE; Kinase, protein; Motility/polarity/chemotaxis; Protein kinase, Ser/Thr (non-receptor); Protein kinase, atypical P42345 2475 1p36.22 human S1415-p 25745815 PTPAILEsLISINNK molecular association, regulation; phosphorylation; enzymatic activity, induced carcinogenesis, induced; cell growth, induced Raptor(DISRUPTS) 24990947 1 1 1 Induce phosphorylation of S6K +ARID4B ARID4B DNA-binding Q4LE39 51742 1q42.3 human K429-sm 12004427 NVKEIKVkEENETEI cell cycle regulation; cell growth, inhibited; transcription, inhibited 16479010 1 2 0 +PIP4K2A PIP4K2A Carbohydrate Metabolism - inositol phosphate; EC 2.7.1.149; Kinase, lipid; Motility/polarity/chemotaxis P48426 5305 10p12.2 human S304-p 450664 DGEEEGEsDGTHPVG PIP5K intracellular localization 10508590 1 0 0 +MEF2B MEF2B iso2 DNA-binding; Transcription factor Q02080-2 100271849 19p13.11 human K319-sm 29649501 PTPPVSIkSERLSPA transcription, inhibited 23974956 1 0 0 Phosphorylation-dependent sumoylation inhibited transcription. +RPTOR Raptor Adaptor/scaffold Q8N122 57521 17q25.3 human S877-p 3205938 HIHQAGGsPPASSTS enzymatic activity, inhibited cell cycle regulation 21900751; 31530866 8 54 0 +Dpysl5 CRMP-5 Q9EQF6 65254 5|5 B1 mouse S534-p 478229 DLHESSFsLSGSQID phosphorylation 29758318 1 6 2 S522A KI mice +Hcn2 HCN2 Channel, cation; Membrane protein, integral; Membrane protein, multi-pass O88703 15166 10|10 C1 mouse Y476-p 457528 FRQKIHDyYEHRYQG activity, induced 16079136 1 1 0 Y476F mutation in Hcn2 and Y554F mutation in Hcn4, abolishes the effect of PP2 on activation. +PDCD4 PDCD4 Apoptosis; Tumor suppressor Q53EL6 27250 10q25.2 human S457-p 458382 RGRKRFVsEGDGGRL protein degradation; molecular association, regulation; ubiquitination; intracellular localization cell motility, induced; cell growth, induced 14-3-3 beta(INDUCES) 16357133; 20661426; 25002506; 27028868 8 74 46 +N Nucleocapsid Protein P59595 1489678 SARSCoV1 S207-p 1868174933 PGSSRGNsPARMASG CoV_nucleocap molecular association, regulation Nucleocapsid Protein(INDUCES) 23717688 4 5 0 di-domain self-association +Ptprr PTP-SL iso2 EC 3.1.3.48; Membrane protein, integral; Motility/polarity/chemotaxis; PHOSPHATASE; Receptor protein phosphatase, tyrosine Q62132-2 19279 10|10 D2 mouse S231-p 31949800 GLQERRGsNVSLTLD intracellular localization; enzymatic activity, inhibited transcription, induced; signaling pathway regulation 24497609 1 0 0 phosphorylation of PTP-SL at S231 induces nuclear localization of MAPK. +PKP2 plakophilin 2 Cell adhesion; Membrane protein, integral; Motility/polarity/chemotaxis Q99959 5318 12p11.21 human S82-p 468460 GNLHRTSsVPEYVYN molecular association, regulation; intracellular localization 14-3-3 beta(INDUCES) 12941695 1 23 109 +DVL2 DVL2 Adaptor/scaffold; Motility/polarity/chemotaxis O14641 1856 17p13.1 human Y275-p 12170305 VTLNMEKyNFLGISI PDZ transcription, induced 19920076 1 2 1 regulates Wnt3a/beta-catenin signaling +ATF2 ATF-2 ACETYLTRANSFERASE; C2H2-type zinc finger protein; EC 2.3.1.48; Transcription factor P15336 1386 2q31.1 human S490-p 455782 QSTEPALsQIVMAPS intracellular localization 15916964 1 0 0 S472/480 are important for ionizing radiation-induced S phase checkpoint control +CGAS cGAS EC 2.7.7.86 Q8N884 115004 6q13 human K479-sm 59117702 LQCLRTEkLENYFIP Mab-21_C activity, induced; protein stabilization 27637147 1 0 0 regulates the stability of activated cGas +SUPT16H SPT16 Transcription initiation complex Q9Y5B9 11198 14q11.2 human K674-ub 22252789 IRPNIAQkRMQGSLE SPT16 molecular association, regulation cell cycle regulation; chromatin organization, altered H3(DISRUPTS); H4(DISRUPTS) 35320725 1 3 0 K674 ubiquitylation of SPT16 regulates DNA replication-coupled histone incorporation into chromatin +PI4KB PIK4CB iso2 Carbohydrate Metabolism - inositol phosphate; EC 2.7.1.67; Kinase, lipid; Motility/polarity/chemotaxis Q9UBF8-2 5298 1q21.3 human S294-p 457621 SNLKRTAsNPKVENE molecular association, regulation; intracellular localization; enzymatic activity, induced 14-3-3 theta(INDUCES); 14-3-3 zeta(INDUCES); 14-3-3 gamma(INDUCES) 16100512; 16606619; 16912074 7 38 9 S294 phosphorylated PIK4CB localizes in Golgi structures; interaction with 14-3-3 protects PIK4CB against dephosphorylation +Dcx Doublecortin iso3 Cytoskeletal; Motility/polarity/chemotaxis Q9CXL6 13193 X|X F2 mouse S47-p 451112 TRTLQALsNEKKAKK cytoskeletal reorganization 33405953 5 0 0 +MCAM MCAM Cell adhesion; Membrane protein, integral NP_001004768 448832 chicken S594-p 1243502 KNVVEVKsDKLSEEA cytoskeletal reorganization 17982057 1 8 0 +AKTIP AKTIP Apoptosis; Membrane protein, peripheral; Vesicle Q9H8T0 64400 16q12.2 human T22-p 1876861200 RSEGEEKtLTGDVKT phosphorylation carcinogenesis, induced; cell growth, induced 35366279 1 1 0 +Tp63 p63 DNA-binding; Transcription factor O88898 22061 16 B1|16 17.37 cM mouse T522-p 20506702 DMNGLSPtQALPPPL activity, induced 21325887 1 0 0 +FEN1 FEN1 DNA repair, damage; DNA-binding; Deoxyribonuclease; EC 3.1.-.-; Nuclear receptor co-regulator; Nucleolus; Ribonuclease P39748 2237 11q12.2 human K354-ac 458855 TGSLSSAkRKEPEPK molecular association, regulation; enzymatic activity, inhibited DNA(DISRUPTS) 11430825 1 2 0 +Bcl11b Bcl-11B C2H2-type zinc finger protein; Nuclear receptor co-regulator; Transcription regulation Q99PV8 58208 12 F1|12 59.1 cM mouse S664-p 14159422 RKPAPLPsPGLGGPA molecular association, regulation SENP1(INDUCES) 22700985 0 7 0 +Irs2 IRS2 Adaptor/scaffold; Motility/polarity/chemotaxis P81122 384783 8 A1.1|8 5.35 cM mouse Y628-p 457098 YNPYPEDyGDIEIGS molecular association, regulation INSR(DISRUPTS) 9195949 2 13 40 +Slc24a2 SLC24A2 Membrane protein, integral; Membrane protein, multi-pass; Transporter; Transporter, SLC family O54701 84550 5q32 rat Y365-p 3721716 LAEELGSyGKLKYYD molecular association, regulation endocytosis, inhibited AP2M1(INDUCES) 23431067 1 0 0 +Eef2 EEF2 Translation; Translation elongation P05197 29565 7q11 rat T57-p 448040 RAGETRFtDTRKDEQ GTP_EFTU activity, inhibited 12194824 39 61 54 Phosphorylation of T56 correlates with inhibition of protein synthesis. +Nfatc2 NFAT1 DNA-binding; Transcription factor Q60591 18019 2 H3|2 88.91 cM mouse S136-p 449623 RGRDAGLsPEQPALA transcription, inhibited 11030334 0 13 0 +Nfkbib IkB-beta Inhibitor Q9JIA3 81525 1q21 rat Y161-p 457691 PRDASDTyLTQSQDH molecular association, regulation apoptosis, induced NFkB-p65(INDUCES) 16286457 1 1 1 +STIL STIL Cell cycle regulation; Cell development/differentiation; Oncoprotein Q15468 6491 1p33 human S428-p 1868450205 QPSVPELsLVLDGNF STIL_N molecular association, regulation; intracellular localization cell cycle regulation; cytoskeletal reorganization CENPJ(INDUCES) 31115335 1 1 0 +MLKL MLKL KINASE; Kinase, protein; Protein kinase, Ser/Thr (non-receptor); Protein kinase, TKL Q8NB16 197259 16q23.1 human T357-p 5891858 FELRKTQtSMSLGTT PK_Tyr_Ser-Thr molecular association, regulation; intracellular localization; protein conformation apoptosis, induced; signaling pathway regulation MLKL(INDUCES) 22265413; 24703947; 26184911; 28758999 7 1 1 induces through the necrosis pathway; oligomer formation during necrosis, binds membrane lipids +ULK1 ULK1 Autophagy; EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, Other; Protein kinase, Ser/Thr (non-receptor) O75385 8408 12q24.33 human S638-p 3176158 FDFPKTPsSQNLLAL enzymatic activity, inhibited; enzymatic activity, induced; phosphorylation autophagy, induced; carcinogenesis, inhibited; autophagy, inhibited; autophagy, altered 21383122; 30093610; 35670018 4 35 41 +RELA NFkB-p65 DNA-binding; Nuclear receptor co-regulator; Transcription factor Q04206 5970 11q13.1 human S205-p 1295501 RVNRNSGsCLGGDEI RHD_dimer molecular association, regulation; intracellular localization transcription, induced; transcription, altered DNA(INDUCES) 15516339; 17991436; 18025230; 23100252 4 1 0 +Myrf MRF DNA-binding; Membrane protein, integral Q3UR85 225908 19|19 A mouse S142-p 20804936 LPDSPPDsGSEAYSP protein degradation; ubiquitination 29472293 1 1 0 +RICTOR RICTOR Adaptor/scaffold; Cell cycle regulation; Ubiquitin conjugating system Q6R327 253260 5p13.1 human T1695-p 40638601 EAEAVLAtPPKQPIV protein degradation; ubiquitination 25897075 1 0 0 +JAM3 JAM3 Cell adhesion; Membrane protein, integral Q9BX67 83700 11q25 human K283-ub 22246354 KQDGESYkNPGKPDG protein degradation; receptor recycling, altered cell motility, induced 31790392 1 3 0 +NEDD9 Cas-L Adaptor/scaffold; Motility/polarity/chemotaxis Q14511 4739 6p24.2 human S296-p 4696722 PVARRHQsLSPNHPP molecular association, regulation AurA(DISRUPTS) 16184168 2 1 3 +Dusp6 DUSP6 EC 3.1.3.16; EC 3.1.3.48; Motility/polarity/chemotaxis; PHOSPHATASE; Protein phosphatase, dual-specificity Q64346 116663 7q13 rat S197-p 455266 SATDSDGsPLSNSQP protein degradation transcription, induced 29375309 5 0 0 +Fmr1 FMR1 Nucleolus; RNA-binding; Translation P35922 14265 X A7.1|X 34.83 cM mouse R545-me 4046001 RGQGGRGrGGGFKGN FXMRP1_C_core molecular association, regulation RNA(DISRUPTS) 20064924 5 0 0 methylation inhibits sc1 RNA binding; R533 and R538 determine association with polyribosomes; methylation doesnot inhibit AATYK mRNA association; different RNAs have distinct molecular requirements for binding to FMR1 +POU4F1 POU4F1 Cell development/differentiation; DNA-binding; Transcription factor Q01851 5457 13q31.1 human S122-p 6311910 DLLDHISsPSLALMA activity, induced cell differentiation, altered; cell differentiation, induced; transcription, induced 16126301; 19135033 2 0 0 activation of galanin promoter induced by retinoic acid +ARHGDIA RhoGDI alpha Apoptosis; Cell adhesion; Cell development/differentiation; G protein regulator, misc.; Motility/polarity/chemotaxis P52565 396 17q25.3 human S174-p 452196 KGMLARGsYSIKSRF Rho_GDI activity, induced; molecular association, regulation; enzymatic activity, induced exocytosis, induced; transcription, altered CDC42(DISRUPTS); RHOA(DISRUPTS); RAC1(DISRUPTS); CDC42 iso1(DISRUPTS) 18768928; 20028975; 29873699; 32003021 7 1 0 RhoA activation; RhoGTPase activation, induces insulin secretion +Nos3 eNOS Amino Acid Metabolism - arginine and proline; EC 1.14.13.39; Oxidoreductase Q62600 24600 4q11 rat S1176-p 447884 TSRIRTQsFSLQERQ activity, induced; enzymatic activity, induced signaling pathway regulation 10025949; 20096547; 25402275; 33772737; 35954193; 36345832 217 18 7 quercetin and myricetin-induced cardioprtection signaling; NO/cGMP signaling +SCARA3 CSR Membrane protein, integral; Receptor, misc. Q6AZY7 51435 8p21.1 human K582-sm 1883988602 QRGAMGPkGEPGIQG sumoylation; protein degradation 29705808 1 1 0 +Cdk1 CDK1 Cell cycle regulation; EC 2.7.11.22; EC 2.7.11.23; KINASE; Kinase, protein; Motility/polarity/chemotaxis; Protein kinase, CMGC; Protein kinase, Ser/Thr (non-receptor) P39951 54237 20p11 rat Y15-p 447610 EKIGEGTyGVVYKGR Pkinase cell cycle regulation 36125973 201 145 3902 +DDX5 DDX5 EC 3.6.4.13; Helicase; Nuclear receptor co-regulator; Nucleolus; RNA splicing; RNA-binding; Spliceosome P17844 1655 17q23.3 human R482-m2 1877752101 VEDRGSGrSRGRGGM molecular association, regulation XRN2(INDUCES) 31267554 1 1 0 represses R-loops +PSEN1 PSEN1 Cell surface; EC 3.4.23.-; Membrane protein, integral; Membrane protein, multi-pass; Mitochondrial; Protease P49768 5663 14q24.2 human S367-p 454173 AVQELSSsILAGEDP Presenilin protein conformation 28132667 2 47 3 PS1 pathogenic conformational shift +RAD9A RAD9A Apoptosis; Cell cycle regulation; DNA replication; Deoxyribonuclease; EC 3.1.11.2 Q99638 5883 11q13.2 human S387-p 449815 SPVLAEDsEGEG___ molecular association, regulation; intracellular localization; phosphorylation cell cycle regulation TOPBP1(INDUCES) 12734188; 20545769; 20724438; 20858457; 25091155; 25454945; 26088138 11 34 1 +GEM GEM G protein; G protein, monomeric; G protein, monomeric, RGK P55040 2669 8q22.1 human S287-p 1211200 NMAFKLKsKSCHDLS molecular association, regulation KPNA5(DISRUPTS) 17605761 2 2 0 interaction abolished in triple phosphomimetic mutant S261/287/289D +CCKBR CCKBR GPCR, family 1; Membrane protein, integral; Membrane protein, multi-pass; Receptor, GPCR P32239 887 11p15.4 human Y438-p 471082 ASLSRLSyTTISTLG molecular association, regulation; phosphorylation SHP-2(INDUCES) 16963136 1 0 0 Mutation of Y438F abrogates AKT phosphorylation on Ser473 and SHP-2 on Y584, but still promotes equivalent amounts of Erk1/2 activation (phospho-Erk epitope). +Snai1 Snail1 C2H2-type zinc finger protein; Transcription factor Q02085 20613 2 H3|2 87.33 cM mouse K137-ub 1872271901 PGLGQLPkQLARLSV protein stabilization; molecular association, regulation carcinogenesis, inhibited; transcription, inhibited GSK3B(INDUCES) 16096638 2 0 0 induces EMT +Esr2 ER-beta DNA-binding; Nuclear receptor O08537 13983 12 C3|12 33.52 cM mouse S61-p 452089 MNYSVPSsTGNLEGG ERbeta_N protein degradation; protein stabilization; protein conformation transcription, altered 11150304; 16984883 2 1 0 phosphorylation results in accelerated degradation, while O-Glycosylation would be predicted to result in stabilization, both localized in nucleus +PIAS1 PIAS1 EC 6.3.2.-; Nuclear receptor co-regulator; SUMO LIGASE; SUMO conjugating system; SUMO ligase; Transcription, coactivator/corepressor O75925 8554 15q23 human S468-p 4700794 DLTIDSSsDEEEEEP molecular association, regulation transcription, inhibited SUMO2(INDUCES); SUMO1(INDUCES); UBC9(INDUCES) 19217413; 24174529 2 9 0 +Limk2 LIMK2 EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, Ser/Thr (non-receptor); Protein kinase, TKL P53670 29524 14q21 rat T505-p 448683 SDRKKRYtVVGNPYW PK_Tyr_Ser-Thr activity, induced 11018042 17 1 1 T505 phosphorylation is also essential for the induction of actin cytoskeletal changes. +CTNND1 CTNND1 Actin-binding; Adaptor/scaffold; Cell adhesion; G protein regulator, misc.; Motility/polarity/chemotaxis O60716 1500 11q12.1 human S312-p 450458 ARRTGTPsDPRRRLR carcinogenesis, induced; cell motility, induced; cell adhesion, inhibited 32589661 4 3 2 +P2rx2 P2X2 Channel, cation; Channel, ligand-gated; Membrane protein, integral; Membrane protein, multi-pass P49653 114115 12q16 rat T372-p 183815300 KKFDKVRtPKHPSSR receptor desensitization, inhibited 28809765 1 0 0 +Trp53 p53 iso2 Activator; DNA-binding; Motility/polarity/chemotaxis; Nuclear receptor co-regulator; Transcription factor; Tumor suppressor Q80ZA1 22059 11 B3|11 42.83 cM mouse K162-ac 59149205 RAMAIYKkSQHMTEV P53 transcription, induced 27705786 2 0 0 +Cdkn1b p27Kip1 Cell cycle regulation; Inhibitor; Oncoprotein; Protein kinase, regulatory subunit P46414 12576 6 G1|6 65.77 cM mouse S178-p 450208 EENVSDGsPNAGTVE cell cycle regulation; cell growth, altered 12856081 5 13 1 +NOP58 NOP5 Cell development/differentiation; Nucleolus; RNA-binding Q9Y2X3 51602 2q33.1 human S502-p 459895 HIKEEPLsEEEPCTS sumoylation 20797634 1 93 22 required for sumoylation of K497 +CTDP1 CTDP1 EC 3.1.3.16; Motility/polarity/chemotaxis; PHOSPHATASE; Protein phosphatase, Ser/Thr (non-receptor); Transcription initiation complex Q9Y5B0 9150 18q23 human S575-p 11276300 AGESLDQsMEEEEEE molecular association, regulation; enzymatic activity, induced transcription, induced GTF2F2(INDUCES) 12591939 1 1 0 +NFKBIA IkB-alpha DNA-binding; Inhibitor P25963 4792 14q13.2 human S262-p 1873119302 QLTWGRPsTRIQQQL phosphorylation carcinogenesis, induced; cell growth, induced; apoptosis, inhibited; transcription, induced 34030642 1 1 0 induce p65 trancsription activity; inhibits phosphorylation of RIP3 and MLKL +Brsk2 BRSK2 EC 2.7.11.1; EC 2.7.11.26; KINASE; Kinase, protein; Protein kinase, CAMK; Protein kinase, Ser/Thr (non-receptor) Q69Z98 75770 7|7 F5 mouse S513-p 3572416 MSNLTPEsSPELAKK protein stabilization; enzymatic activity, inhibited; phosphorylation 23790753 1 7 6 inhibits axon branching (activated in BRSK2 18A mutant) +Alyref2 Refbp2 DNA-binding; RNA-binding Q9JJW6 56009 1|1 H3 mouse R32-m1 13906414 GGGPRRNrPAIARGG molecular association, regulation RNA(DISRUPTS) 20129943 1 1 0 +HSPA1A HSP70 Chaperone; Heat shock protein; Motility/polarity/chemotaxis P0DMV8 3303 6p21.33 human Y525-p 450945 MVQEAEKyKAEDEVQ HSP70 intracellular localization 10843914 1 3 22 Phosphorylation at Y525 facilitates nuclear acumulation of HSP70 following heat stress. +Stxbp1 STXBP1 Vesicle O08599 20910 2 B|2 22.09 cM mouse S241-p 36440508 DRGFDPSsPVLHELT Sec1 protein degradation; ubiquitination 27056679 1 0 0 endocannabinoid-induced depression of glutamate release +Scn4a SCN4A Channel, sodium; Membrane protein, integral; Membrane protein, multi-pass P15390 rat S56-p 50659300 EPERKPRsDLEAGKN activity, induced 26485043 1 0 0 augments SCN4A current +MBD4 MBD4 Apoptosis; DNA repair, damage; Deoxyribonuclease; EC 3.2.2.- O95243 8930 3q21.3 human K377-sm 1877787602 HLHTDILkRGSEMDN DNA repair, induced 31476572 1 1 0 +CALR Calreticulin ACETYLTRANSFERASE; Acetyltransferase; Calcium-binding; Motility/polarity/chemotaxis; Nuclear receptor co-regulator; Secreted; Secreted, signal peptide P27797 811 19p13.13 human K207-ac 4219813 WDFLPPKkIKDPDAS Calreticulin protein conformation; enzymatic activity, induced 18795239; 33585151 2 1 0 K207 of P-domain is the active site residue controlling TAase activity. +ATRX ATRX DNA repair, damage; EC 3.6.4.12; Helicase; Ubiquitin conjugating system P46100 546 Xq21.1 human S2487-p 23052326 RSKNPGPsQGKSM__ cell cycle regulation 25803170 0 3 3 inability of cells to undergo geroconversion following CDK4 inhibition +BRD7 BRD7 Cell cycle regulation; Histone-binding; Transcription regulation; Tumor suppressor Q9NPI1 29117 16q12.1 human K173-ub 1877241401 PGYSMIIkHPMDFST Bromodomain protein degradation cell motility, induced; cell growth, inhibited USP24(INDUCES) 33257797 1 0 0 +MC2R MC2R GPCR, family 1; Membrane protein, integral; Membrane protein, multi-pass; Receptor, GPCR Q01718 4158 18p11.21 human S280-p 456325 PFIYAFRsPELRDAF receptor desensitization, altered; activity, inhibited 12456795 1 0 0 +IKBKG IKKG Adaptor/scaffold; Protein kinase, regulatory subunit Q9Y6K9 8517 Xq28 human S68-p 1226900 LRDAIRQsNQILRER NEMO molecular association, regulation IKKG(DISRUPTS); IKKB(DISRUPTS) 17977820 1 0 0 phosphorylation attenuates amino-terminal protein dimerization; decreases TNF-alpha-induced NF-kB and IKKalpha activity. +UBASH3A STS2 PHOSPHATASE; Protein phosphatase, tyrosine (non-receptor) P57075 53347 21q22.3 human K240-ub 486271 LHLTLAHkFYPHHQR receptor internalization, induced; protein degradation; molecular association, regulation; ubiquitination endocytosis, inhibited EGFR(DISRUPTS) 16429130 2 4 2 Monoubiquitination of Sts1?2 and Hrs affect regulation of cargo sorting +PGR PR DNA-binding; Nuclear receptor; Transcription factor P06401 5241 11q22.1 human S400-p 449842 GAEASARsPRSYLVA Prog_receptor protein degradation; intracellular localization cell growth, induced; transcription, induced 15572662; 25514083 8 3 0 +NR3C2 MCR DNA-binding; Nuclear receptor P08235 4306 4q31.23 human S263-p 18503884 NVGSPLSsPLSSMKS protein degradation; ubiquitination transcription, inhibited 22798426 1 1 0 +PREX1 PREX1 GEF; GEF, Rac/Rho Q8TCU6 57580 20q13.13 human S1169-p 18704703 DTMSYRDsYSECNSN activity, induced cell growth, induced 21042280; 23899556; 27788493 3 0 0 increased Rac activity +MAP3K3 MEKK3 EC 2.7.11.25; KINASE; Kinase, protein; Protein kinase, STE; Protein kinase, Ser/Thr (non-receptor) Q99759 4215 17q23.3 human S526-p 458796 MSGTGMRsVTGTPYW Pkinase enzymatic activity, induced transcription, altered 16362041; 18308725 4 2 0 necessary for MEKK3 T294 phosphorylation and its interaction with 14-3-3beta; S526 functions in LPS-induced IL6 transcription. +Gata4 GATA4 Motility/polarity/chemotaxis; Transcription factor Q08369 14463 14 D1|14 33.24 cM mouse K318-ac 18380903 KEGIQTRkRKPKNLN cell growth, induced; transcription, induced 20833366 1 0 0 +Nos3 eNOS Amino Acid Metabolism - arginine and proline; EC 1.14.13.39; Oxidoreductase P70313 18127 5 A3|5 11.32 cM mouse Y656-p 2811400 FGLGSRAyPHFCAFA Flavodoxin_1 molecular association, regulation HSP90A(DISRUPTS); PKM(DISRUPTS); Calmodulin(DISRUPTS) 31328803 6 1 0 preserves Nitric Oxide bioavailability, inhibits s-nitrosation of PKM2 +ZBTB16 PLZF C2H2-type zinc finger protein; DNA-binding; Oncoprotein; Transcription, coactivator/corepressor Q05516 7704 11q23.2 human K653-ac 50455005 QKHMKGHkPEEIPPD molecular association, regulation; acetylation; intracellular localization chromatin organization, altered; transcription, inhibited DNA(INDUCES) 26405459 1 0 0 induces histone acetylation and DNA hypermethylation +Gria1 GluR1 Channel, calcium; Channel, ligand-gated; Membrane protein, integral; Membrane protein, multi-pass P19490 50592 10q22 rat S849-p 448565 FCLIPQQsINEAIRT activity, induced; protein processing; intracellular localization; receptor internalization, inhibited neural plasticity GluR2(INDUCES) 15630695; 17428797; 17472959; 26626486; 34251729; 35053838; 35625355; 8663994 94 4 3 +SMAD2 SMAD2 DNA-binding; Transcription factor Q15796 4087 18q21.1 human S250-p 448795 TGSPAELsPTTLSPV activity, induced; protein degradation; protein stabilization; molecular association, regulation; intracellular localization; protein conformation; phosphorylation cell growth, induced; cell differentiation, induced; cell motility, altered; cell motility, inhibited; transcription, induced; transcription, inhibited; signaling pathway regulation SETD2(INDUCES); SMAD4(INDUCES) RNA(INDUCES) 10197981; 12193595; 19115199; 27153775; 31995604; 33676893; 34504019 11 1 0 inhibits C-terminal phosphorylation and hence TGF-B signaling +MARCKS MARCKS Actin-binding; Motility/polarity/chemotaxis P29966 4082 6q21 human S163-p 447787 KRFSFKKsFKLSGFS MARCKS exocytosis, inhibited 21762971 24 30 7 induce MUC5AC secretion by cold +Drd1 DRD1 GPCR, family 1; Membrane protein, integral; Membrane protein, multi-pass; Receptor, GPCR P18901 24316 17p14 rat T268-p 3078003 KMSFKREtKVLKTLS 7tm_1 intracellular localization 11901220 1 0 0 +CNN1 calponin 1 Actin-binding; Contractile; Motility/polarity/chemotaxis; Myosin-binding P26932 396522 chicken S175-p 450890 MGTNKFAsQQGMTAY Calponin molecular association, regulation ACTA1(DISRUPTS) 10873572 3 2 0 f-actin (rabbit skeletal muscle) shown by co-sedimentation +CDC25C CDC25C EC 3.1.3.48; Motility/polarity/chemotaxis; PHOSPHATASE; Protein phosphatase, dual-specificity P30307 995 5q31.2 human T130-p 449911 PAQLLCStPNGLDRG cell cycle regulation; cell adhesion, altered 20668692; 8119945 4 0 7 +Nos3 eNOS Amino Acid Metabolism - arginine and proline; EC 1.14.13.39; Oxidoreductase Q62600 24600 4q11 rat S1178-p 467802 RIRTQSFsLQERQLR enzymatic activity, induced 17376767 11 8 1 +NR4A2 NR4A2 DNA-binding; Nuclear receptor P43354 4929 2q24.1 human S125-p 487428 GSVYYKPsSPPTPTT transcription, induced 17890097 1 0 0 S125C mutation attenuated NR4A2 -induced transcriptional activity. +NPHP1 NPHP1 Cell adhesion O15259 4867 2q13 human S121-p 26395106 PTEEEEEsESEDSED molecular association, regulation; intracellular localization PACS-1(INDUCES) 16308564 1 0 0 +Rps6ka1 p90RSK EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, AGC; Protein kinase, Ser/Thr (non-receptor); Translation Q63531 81771 5q36 rat S363-p 447989 TSRTPRDsPGIPPSA Pkinase_C activity, induced 9430688 42 47 4 +RUNX2 AML3 DNA-binding; Transcription factor Q13950 860 6p21.1 human S43-p 10892805 PGKMSDVsPVVAAQQ molecular association, regulation osterix(INDUCES) 25122769 2 1 0 +Ikzf1 Ikaros C2H2-type zinc finger protein; DNA-binding; Transcription factor Q03267 22778 11 A1|11 7.02 cM mouse S388-p 451351 REASPSNsCQDSTDT activity, inhibited cell cycle regulation DNA(DISRUPTS) 15024069 2 1 3 +NFATC4 NFAT3 DNA-binding; Transcription factor Q14934 4776 14q12 human S170-p 448860 GGAFFSPsPGSSSLS intracellular localization; activity, inhibited cell differentiation, altered; transcription, altered; cell growth, altered 11997522; 17213202 7 0 1 +PCYT1A PCYT1A EC 2.7.7.15; Lipid Metabolism - glycerophospholipid; Transferase P49585 5130 3q29 human S319-p 451322 QAISPKQsPSSSPTR intracellular localization 32186954 4 46 10 +CBX4 CBX4 EC 6.3.2.-; SUMO LIGASE; SUMO conjugating system; SUMO ligase; Transcription, coactivator/corepressor O00257 8535 17q25.3 human T497-p 470079 SLQVKPEtPASAAVA sumoylation; molecular association, regulation; intracellular localization; enzymatic activity, induced cell cycle regulation; transcription, inhibited RING1(INDUCES) 17018294; 30317550 2 0 0 +Stxbp3 STXBP3 Vesicle Q60770 20912 3|3 F3 mouse Y219-p 463816 EKKLEDYyKIDEKGL Sec1 molecular association, regulation; intracellular localization exocytosis, induced STX4(DISRUPTS); DOC2B(INDUCES) 16638745; 18541526; 21444687; 23937695 4 0 0 GLUT4 vesicle exocytosis induced; Munc18c dissociation from syntaxin 4; 2-deoxy-glucose uptake in adipocytes +Ntrk1 TrkA EC 2.7.10.1; KINASE; Kinase, protein; Membrane protein, integral; Oncoprotein; Protein kinase, TK; Protein kinase, tyrosine (receptor) P35739 59109 2q34 rat Y683-p 447763 RDIYSTDyYRVGGRT PK_Tyr_Ser-Thr molecular association, regulation; enzymatic activity, induced cell cycle regulation; cytoskeletal reorganization; cell growth, altered DNAJA3(INDUCES) 10656690; 14647472; 15753086 14 3 10 +AKAP12 AKAP12 Adaptor/scaffold Q02952 9590 6q25.1 human S696-p 480148 KKRARRGsSSDEEGG receptor desensitization, inhibited; molecular association, regulation ADRB2(INDUCES) 14657015 1 25 159 +Mip AQP0 Channel, misc.; Membrane protein, integral; Membrane protein, multi-pass; Transporter, aquaporin family P09011 25480 7q11 rat S229-p 453399 FPRLKSVsERLSILK molecular association, regulation 22194645 2 2 0 No differences in the interaction with filensin between the AQP0 COOH-terminal peptide and its pseudophosphorylated proteins +GRIN2A NMDAR2A Channel, ligand-gated; Membrane protein, integral; Membrane protein, multi-pass Q12879 2903 16p13.2 human Y1267-p 461052 PATGEQVyQQDWAQN NMDAR2_C activity, induced 10195142 4 1 25 potentiation of receptor currents mediated by Src +Stk17b DRAK2 EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, CAMK; Protein kinase, Ser/Thr (non-receptor) Q91XS8 170904 9q31 rat S350-p 1735800 PEDDSLLsKRFRFDD intracellular localization 18084041 2 1 0 regulates the activity of the NLS +AKAP13 AKAP13 Adaptor/scaffold; GEF; GEF, Rac/Rho; Nuclear export; Nuclear receptor co-regulator; Oncoprotein Q12802 11214 15q25.3 human S1565-p 452184 LSPFRRHsWGPGKNA molecular association, regulation; activity, inhibited; phosphorylation 14-3-3 beta(INDUCES); 14-3-3 sigma(INDUCES); 14-3-3 gamma(INDUCES) 15229649; 15324660; 36402225 3 27 11 regulates phosphorylation at T2467 +Add1 ADD1 Cytoskeletal; Motility/polarity/chemotaxis Q63028 24170 14q21 rat S724-p 449829 KKKFRTPsFLKKSKK intracellular localization cytoskeletal reorganization 9607561; 9679146 24 57 158 +Osbpl3 OSBPL3 iso3 Endoplasmic reticulum D3Z194 71720 6|6 B2.3 mouse S250-p 3212427 DVLHRTYsAPAINAI apoptosis, inhibited 31509750 1 32 11 inhibits insulin secretion +Rps6ka1 p90RSK EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, AGC; Protein kinase, Ser/Thr (non-receptor); Translation Q63531 81771 5q36 rat S154-p 10355000 GDLFTRLsKEVMFTE Pkinase molecular association, regulation; intracellular localization; enzymatic activity, induced 14-3-3 beta(INDUCES) 12618428 2 0 0 !4-3-3 binding inhibits S363 andd S380 phosphorylation and enzyme activity.; 14-3-3B binding in vitro and in vivo +YAP1 YAP1 Oncoprotein; Transcription, coactivator/corepressor P46937 10413 11q22.1 human S419-p 31884052 TPDDFLNsVDEMDTG protein degradation 28481329 1 4 0 +Mff MFF Membrane protein, integral; Mitochondrial Q6PCP5 75734 1|1 C5 mouse S129-p 470753 GRLKRERsMSENAVR Miff molecular association, regulation signaling pathway regulation DRP1(INDUCES) 31693892 4 43 91 +DDX3X DDX3 Cell cycle regulation; EC 3.6.4.13; Helicase; RNA-binding; Spliceosome; Translation initiation O00571 1654 Xp11.4 human S102-p 11183059 RFDDRGRsDYDGIGS molecular association, regulation; phosphorylation IRF3(INDUCES) 23478265 1 9 68 102A (mutant) increased autophosphorylation of IRF3 +SOCS3 SOCS3 Inhibitor O14543 9021 17q25.3 human Y221-p 450447 IREFLDQyDAPL___ protein degradation; molecular association, regulation transcription, altered NCK1(INDUCES); CRK(INDUCES); TCEB1(DISRUPTS) 12783885; 15173187; 16352613 4 0 0 +Plcb4 PLCB4 Carbohydrate Metabolism - inositol phosphate; EC 3.1.4.11; Phospholipase Q91UZ1 18798 2 F3|2 66.64 cM mouse T886-p 468465 NPAKANVtPQSSSEL activity, induced signaling pathway regulation 33970189 1 25 0 T cell activation; induces TCR signaling +SNAI1 Snail1 C2H2-type zinc finger protein; Transcription factor O95863 6615 20q13.13 human S92-p 452602 VAELTSLsDEDSGKG protein degradation; molecular association, regulation; activity, inhibited carcinogenesis, inhibited; transcription, inhibited; transcription, altered SAP30(INDUCES) 19923321; 22562247 2 5 0 reqired for cell survival ; maintenance of epithelial phenotype, prevents EMT +Rrad RRAD G protein; G protein, monomeric; G protein, monomeric, RGK O88667 56437 8|8 D3 mouse S39-p 4700224 APPLHRRsMPVDERD activity, induced; molecular association, regulation CACNA1C(DISRUPTS) 31969708 2 16 0 induces Cav1.2 currents +SNAI1 Snail1 C2H2-type zinc finger protein; Transcription factor O95863 6615 20q13.13 human K235-ub 231166704 QTHSDVKkYQCQACA protein stabilization 28892081 1 0 0 metastasis +TAOK1 TAO1 EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, STE; Protein kinase, Ser/Thr (non-receptor) Q7L7X3 57551 17q11.2 human T440-p 23150854 RNREHFAtIRTASLV molecular association, regulation cytoskeletal reorganization MYL5(INDUCES); DBN1(INDUCES) Other(INDUCES) 25456499; 36595571 2 2 1 induces binding to membrane phosphoinositides; spine development +GRIK1 GluR5 iso2 Channel, ligand-gated; Membrane protein, integral; Membrane protein, multi-pass P39086-2 2897 21q21.3 human S879-p 457626 QKKIKKKsRTKGKSS receptor desensitization, altered; receptor internalization, altered 17898803 2 0 0 induced by phorbol ester +CDC25A CDC25A EC 3.1.3.48; Motility/polarity/chemotaxis; PHOSPHATASE; Protein phosphatase, dual-specificity P30304 993 3p21.31 human S82-p 450248 GSSESTDsGFCLDSP protein degradation; molecular association, regulation; ubiquitination; phosphorylation cell cycle regulation BTRC(INDUCES); FBW1B(INDUCES) 14603323; 14681206; 14752276; 15798217; 19734889; 20348946 6 0 0 +ELAVL1 HuR RNA-binding Q15717 1994 19p13.2 human S304-p 27156803 EAAMAIAsLNGYRLG RRM_1 protein degradation; molecular association, regulation; intracellular localization BTRC(INDUCES) 23115237 1 0 0 +SNCA SNCA Adaptor/scaffold P37840 6622 4q22.1 human Y125-p 448279 VDPDNEAyEMPSEEG Synuclein molecular association, regulation; protein stabilization; activity, inhibited SNCA(DISRUPTS) 11821392; 24412932; 36690898 9 1 0 +H3c1 H3 DNA-binding P68433 360198 13|13 A3.1 mouse K4-me 1668802 ____ARTkQTARKST Histone transcription, induced 21703230 29 1 0 +HSP90AA1 HSP90A Chaperone; Heat shock protein P07900 3320 14q32.31 human K615-me 1873645100 ANMERIMkAQALRDN HSP90 molecular association, regulation cytoskeletal reorganization Titin(INDUCES) 22241783 1 1 0 +FANCA FANCA DNA repair, damage O15360 2175 16q24.3 human S1449-p 460787 AAPDADLsQEPHLF_ molecular association, regulation; ubiquitination chromatin organization, altered DNA(INDUCES) 19109555 1 5 33 level of monoubiquitinated FANCD2 was decreased in FANCA S1449A mutant +TP53 p53 Activator; DNA-binding; Motility/polarity/chemotaxis; Nuclear receptor co-regulator; Transcription factor; Tumor suppressor P04637 7157 17p13.1 human K382-ac 458977 QSTSRHKkLMFKTEG protein degradation; molecular association, regulation; acetylation; protein stabilization; activity, induced; ubiquitination; intracellular localization; protein conformation cell cycle regulation; apoptosis, altered; carcinogenesis, induced; apoptosis, induced; cell motility, inhibited; signaling pathway regulation; cell growth, induced; transcription, inhibited; carcinogenesis, inhibited; cell growth, inhibited; transcription, induced; transcription, altered; DNA repair, induced; autophagy, induced; cell differentiation, induced; apoptosis, inhibited CBFB(DISRUPTS); polybromo 1(INDUCES); TAF1(INDUCES); S100B(DISRUPTS); S100A2(DISRUPTS); CBP(INDUCES); BCL2L2(INDUCES); MDC1(INDUCES); POLA2(INDUCES); ING4(INDUCES); ING5(INDUCES); BANP(INDUCES); BRMS1L(INDUCES); p53(DISRUPTS); GTF2H1(INDUCES); MYH11(DISRUPTS); PC4(INDUCES); p21Cip1(DISRUPTS); MDM2(INDUCES) DNA(INDUCES); DNA(DISRUPTS) 10910364; 11094089; 11099047; 11250899; 11672523; 11740489; 11971195; 12006491; 12093737; 12421820; 12750254; 14522900; 14665630; 14759370; 14976551; 14982997; 15141169; 15361854; 15520174; 15746940; 16107876; 16291740; 16322229; 16426974; 16537920; 16540636; 16618797; 17047066; 17121856; 17272277; 17403783; 17668048; 17977830; 17996705; 18056437; 18243116; 18419600; 18485870; 18523266; 18769132; 19085961; 19265193; 19339993; 19377469; 19731376; 19819244; 19828042; 20024960; 20075864; 20157519; 20171273; 20935676; 21297583; 21465263; 21565980; 21586571; 21654327; 21857907; 22081073; 22249259; 22285752; 22576474; 22731250; 22815158; 23148227; 23184057; 23297003; 23329847; 23384296; 23416275; 23431171; 23576563; 23678107; 23982736; 24038750; 24077923; 24194938; 25426556; 25521755; 25605253; 26363315; 26387755; 26578795; 26629991; 26784898; 27208501; 27345396; 27402830; 27423454; 28182012; 28410205; 28601088; 28655792; 30710424; 31296660; 31634504; 31680191; 31863007; 32093281; 32224984; 32831651; 33097607; 33982878; 34188177; 34798143; 34947995; 35872650; 36007676; 36257192; 36575468; 9288740; 9744860 216 10 0 +P2RY1 P2RY1 GPCR, family 1; Membrane protein, integral; Membrane protein, multi-pass; Receptor, GPCR P47900 5028 3q25.2 human S252-p 60152501 IYKDLDNsPLRRKSI 7tm_1 protein stabilization; molecular association, regulation PIN1(INDUCES) 27863418 1 0 0 +SKIL SKIL Cell development/differentiation; Transcription, coactivator/corepressor P12757 6498 3q26.2 human K383-sm 3144803 QSWYPVIkQEGDHVS carcinogenesis, inhibited; cell growth, inhibited; transcription, inhibited 16966324; 28493978 3 0 0 +Cgas cGAS EC 2.7.7.86 Q8C6L5 214763 9|9 E1 mouse K491-m1 1883544404 KSKEFLSkKIEYERN molecular association, regulation DNA repair, inhibited CCDC101(INDUCES); PARP1(DISRUPTS) 35210392 1 0 0 +Abca1 ABCA1 Membrane protein, integral; Membrane protein, multi-pass; Transporter; Transporter, ABC family; Vesicle P41233 11303 4 B2|4 28.57 cM mouse T1305-p 450309 IDPESREtDLLSGMD protein degradation; protein processing 12869555 1 0 0 Mutants showed increase of cell surface protein levels. ; T1286A and T1305A mutants are not degraded by calpain or stabilized by apoA-1. +Gja1 GJA1 Channel, misc.; Membrane protein, integral; Membrane protein, multi-pass; Motility/polarity/chemotaxis P08050 24392 20q11 rat S365-p 459207 IVDQRPSsRASSRAS activity, induced; protein conformation 12417300; 18086922; 29021339 15 15 2 channel open, (S373 dephosphorylated) +MDC1 MDC1 Cell cycle regulation Q14676 9656 6p21.33 human T98-p 20583303 DCGSLNGtQILRPPK FHA molecular association, regulation; protein conformation cell cycle regulation; DNA repair, induced; signaling pathway regulation MDC1(INDUCES); BRCA1(INDUCES); 53BP1(INDUCES) 21705321; 22234877 2 1 0 T98A mutation disrupts MDC1 dimerization ; ATM signaling following DNA damage; important for the structural stability of MDC1 +VIM Vimentin Cytoskeletal; Motility/polarity/chemotaxis P08670 7431 10p13 human S66-p 451765 GVYATRSsAVRLRSS Filament_head molecular association, regulation cytoskeletal reorganization Vimentin(DISRUPTS) 11895474 5 11 20 +Musk MUSK EC 2.7.10.1; KINASE; Kinase, protein; Membrane protein, integral; Protein kinase, TK; Protein kinase, tyrosine (receptor) Q61006 18198 4 B3|4 31.87 cM mouse Y553-p 2848304 RLHPNPMyQRMPLLL molecular association, regulation; intracellular localization DOK7(INDUCES); CRK(INDUCES) 34163073 2 3 0 peptide pull-down assay, recruitment of CRK +Tnnt2 TNNT2 iso2 Motility/polarity/chemotaxis; Motor P50753-2 24837 13q13 rat T204-p 451556 RKSGKRQtEREKKKK Troponin protein conformation 24708997 7 0 0 T204E mutant blunts Ca2+ sensitivity, PKC phosphorylation of these residues can increase or decrease Ca2+ sensitivity and cardiac regulation +TP53 p53 Activator; DNA-binding; Motility/polarity/chemotaxis; Nuclear receptor co-regulator; Transcription factor; Tumor suppressor P04637 7157 17p13.1 human K386-ac 486382 RHKKLMFkTEGPDSD protein stabilization; molecular association, regulation; intracellular localization apoptosis, induced; transcription, induced; transcription, altered S100B(DISRUPTS); S100A2(DISRUPTS) 18485870; 19339993; 19377469; 19819244; 21297583; 31680191 12 2 1 20, 164, 305, 320, 370/372/373, 381/382/386 K-R mutants diminsished transactivation, and selective regulation of target genes expression through distinct mechanisms; ZNF420 (Apak) represses p53 activity by attenuating its acetylation +APP APP Apoptosis; Cell surface; Membrane protein, integral; Receptor, misc.; Transcription factor P05067 351 21q21.3 human S679-p 480465 DAEFRHDsGYEVHHQ Beta-APP molecular association, regulation; protein stabilization; protein conformation cytoskeletal reorganization APP(INDUCES); APP(DISRUPTS) 21527912; 22267728; 25023775; 27252381; 28031462; 30210271; 31097588 9 2 0 modify the morphologies of amyloid fibrils +RB1 Rb Nuclear receptor co-regulator; Oncoprotein; Transcription, coactivator/corepressor; Tumor suppressor P06400 5925 13q14.2 human T252-p 449821 PINGSPRtPRRGQNR activity, induced; protein degradation; acetylation; molecular association, regulation; ubiquitination; activity, inhibited; phosphorylation cell cycle regulation; carcinogenesis, induced; cell growth, inhibited; transcription, induced; transcription, altered; signaling pathway regulation; cell growth, induced; apoptosis, inhibited; transcription, inhibited BRD4(DISRUPTS); E2F1(INDUCES); EID1(DISRUPTS); HDAC5(DISRUPTS) 17599043; 17996702; 22279936; 27642049; 33419772; 36274096; 36637424 21 23 68 +Mtor mTOR Autophagy; EC 2.7.11.1; KINASE; Kinase, protein; Motility/polarity/chemotaxis; Protein kinase, Ser/Thr (non-receptor); Protein kinase, atypical Q9JLN9 56717 4 E2|4 78.76 cM mouse S2448-p 447578 RSRTRTDsYSAGQSV intracellular localization cell cycle regulation; carcinogenesis, induced; cell motility, induced; transcription, induced; signaling pathway regulation; neural plasticity; autophagy, induced; cell growth, induced; cell differentiation, induced; apoptosis, inhibited; autophagy, inhibited; translation, induced 14559816; 18851840; 21550972; 32071086; 33637094; 34695513; 35210408; 35696363; 35857844; 36012713; 36310322 218 18 106 +STK39 STLK3 EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, STE; Protein kinase, Ser/Thr (non-receptor) Q9UEW8 27347 2q24.3 human S323-p 450932 LCLQKDPsKRPTAAE Pkinase enzymatic activity, induced 14988727 1 0 0 +Ulk1 ULK1 Autophagy; EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, Other; Protein kinase, Ser/Thr (non-receptor) O70405 22241 5|5 F mouse K162-ac 27850502 NPSNIRVkIADFGFA Pkinase enzymatic activity, induced autophagy, induced 22717509 2 1 0 +AGAP2 CENTG1 iso2 GAP; GAP, ARF; Motility/polarity/chemotaxis; Tumor suppressor Q99490-2 116986 12q14.1 human S472-p 477808 RNLARALsTDCTPSG protein degradation; molecular association, regulation; phosphorylation apoptosis, inhibited; transcription, inhibited; signaling pathway regulation UNC5B(INDUCES) 21460185 1 12 102 regulates p53 stability and transcription, induces Akt and Akt-p53 pathway +Ndufs4 NDUFS4 EC 1.6.5.3; EC 1.6.99.3; Energy Metabolism - oxidative phosphorylation; Mitochondrial; Oxidoreductase Q9CXZ1 17993 13|13 D2.2 mouse S173-p 2103602 WNKRTRVsTK_____ protein stabilization signaling pathway regulation 32641832 3 1 0 Regulates HIF1 pathway +LYN LYN EC 2.7.10.2; KINASE; Kinase, protein; Oncoprotein; Protein kinase, TK; Protein kinase, tyrosine (non-receptor) P07948 4067 8q12.1 human S13-p 1983291 SKGKDSLsDDGVDLK intracellular localization 33004926 1 43 1 +UBTF UBF DNA-binding; Nucleolus; Transcription factor P17480 7343 17q21.31 human K352-ac 25344501 KKCDQKKkDYEVELL HMG_box_2 molecular association, regulation transcription, induced DNA(INDUCES) 21546905 1 1 0 +PRKAA2 AMPKA2 Autophagy; EC 2.7.11.1; EC 2.7.11.27; EC 2.7.11.31; KINASE; Kinase, protein; Protein kinase, CAMK; Protein kinase, Ser/Thr (non-receptor) P54646 5563 1p32.2 human K391-ub 964497646 LDALNTTkPKSLAVK enzymatic activity, inhibited 31996460 1 1 0 +Sox9 SOX9 DNA-binding; Transcription factor Q04887 20682 11 E2|11 77.27 cM mouse R179-me 10338207 YKYQPRRrKSVKNGQ molecular association, regulation cell cycle regulation; cell growth, induced; transcription, induced CTNNB1(DISRUPTS) 19725955 1 0 0 promotes cyclin D1 expression, regulates endochondral ossification, chondrocyte/cartilage development during embryogenesis +RPS6KA1 p90RSK EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, AGC; Protein kinase, Ser/Thr (non-receptor); Translation Q15418 6195 1p36.11 human K110-sm 1881518209 VRDRVRTkMERDILA molecular association, regulation; phosphorylation EIF4B(INDUCES) 34871326 1 0 0 SUMO-SIM interaction contributes to RSK1-eIF4B association; sites incudinge IF4B (Ser 422 and Ser 425, 29.91 fold), SETD1A (Ser 915 and Ser 916, 25.76 fold), LMNA (Ser 404 and Ser 406, 16.42 fold), ZNF 217 (Ser 975, 13.27 fold); SUMOylation is required for is required for replication and virus production of KSHV; affect eIF4B phosphorylation by RSK1 in vitro; SUMOylation affects the phosphorylation levels of its substrates +Sh3pxd2a Tks5 Adaptor/scaffold O89032 14218 19|19 C3 mouse Y619-p 3736027 ALEEETIyENEGFRP cell cycle regulation; cell motility, altered 18515860 1 1 1 +HAVCR2 TIM-3 Membrane protein, integral; Receptor, misc. Q8TDQ0 84868 5q33.3 human Y265-p 470136 IRSEENIyTIEENVY receptor inactivation, induced; molecular association, regulation; intracellular localization signaling pathway regulation; transcription, inhibited STAT1(INDUCES); Fyn(INDUCES); P38A(INDUCES); PIK3R1(INDUCES) 26492563; 27757304; 31848194 5 0 0 suppresses TCR-mediated activation of the NF-kB/NFAT reporter activity; PI3K-Akt-mTOR pathway for NK cells in liver; Galectin-9 increased the binding between Tim-3- and STAT1, nuclear localization of STAT1 is linhibited, enhanced SOCS1 expression +DDX5 DDX5 EC 3.6.4.13; Helicase; Nuclear receptor co-regulator; Nucleolus; RNA splicing; RNA-binding; Spliceosome P17844 1655 17q23.3 human R502-m1 6008922 DRYSAGKrGGFNTFR P68HR molecular association, regulation XRN2(INDUCES) 31267554 1 7 53 represses R-loops +CTNNB1 CTNNB1 Actin-binding; Cell adhesion; Motility/polarity/chemotaxis; Nuclear receptor co-regulator; Oncoprotein; Transcription factor P35222 1499 3p22.1 human T102-p 3075002 RAAMFPEtLDEGMQI protein degradation cell motility, altered CTNNA1(INDUCES) 12432063 2 0 0 +IRS2 IRS2 Adaptor/scaffold; Motility/polarity/chemotaxis Q9Y4H2 8660 13q34 human S1100-p 453065 PEAARVAsPTSGVKR cell growth, inhibited 25297629 2 43 0 induces immunogenicity, phospho-peptidesfor T-cell recognition showed some control of tumor growth in vivo +Dab1 DAB1 iso2 Adaptor/scaffold P97318-2 13131 4 C6|4 47.79 cM mouse T385-p 479416 AMFQGPLtPLATVPG phosphorylation 16529723 1 0 0 inhibits tyrosine phosphorylation +Tbx21 TBX21 DNA-binding; Transcription factor Q9JKD8 57765 11|11 D mouse S502-p 322212300 RRISPYPsSGDSSSP cell growth, inhibited; transcription, induced 29133416 1 0 0 IFN? transcription, attenuates colon cancer metastasis in RSK2 KO mice +Dvl1 DVL1 Inhibitor P51141 13542 4 E2|4 87.61 cM mouse S142-p 470074 TGTESMVsHRRERAR Dishevelled activity, induced cell differentiation, altered 16965538 1 0 0 contributes to B-catenin-dependent Wnt signaling; mutation of this site inhibits double axis formation in Xenopus embryos +IRF7 IRF7 DNA-binding; Transcription factor Q92985 3665 11p15.5 human S479-p 2868600 SLDSSSLsLCLSSAN activity, induced; molecular association, regulation; intracellular localization; protein conformation transcription, induced H4(DISRUPTS) 10893229; 25225665 4 0 0 +PRKG1 PKG1 EC 2.7.11.12; KINASE; Kinase, protein; Protein kinase, AGC; Protein kinase, Ser/Thr (non-receptor) Q13976 5592 10q11.23-q21.1 human S65-p 51573802 TTRAQGIsAEPQTYR ubiquitination; enzymatic activity, induced 12080049; 19168131 3 0 0 +SIRT6 SIRT6 DEACETYLASE; DEUBIQUITINASE; Deacetylase; EC 2.4.2.31; EC 3.5.1.-; Transferase Q8N6T7 51548 19p13.3 human K33-ac 1876885600 PPEELERkVWELARL chromatin organization, altered; cell growth, inhibited; DNA repair, inhibited 32538779 1 0 0 +Cdk2 CDK2 Cell cycle regulation; EC 2.7.11.22; KINASE; Kinase, protein; Protein kinase, CMGC; Protein kinase, Ser/Thr (non-receptor) P97377 12566 10|10 D3 mouse T160-p 447739 GVPVRTYtHEVVTLW Pkinase enzymatic activity, induced 11509654 40 35 237 +NR1H4 NR1H4 iso2 DNA-binding; Nuclear receptor Q96RI1-2 9971 12q23.1 human S154-p 4245800 CKGFFRRsITKNAVY zf-C4 activity, induced; protein degradation; molecular association, regulation transcription, induced; transcription, inhibited PGC-1 alpha(INDUCES) 18755856; 27571290 2 0 0 +HSPB1 HSP27 Chaperone; Heat shock protein; Motility/polarity/chemotaxis; SUMO LIGASE; SUMO ligase P04792 3315 7q11.23 human S15-p 448401 FSLLRGPsWDPFRDW protein degradation; sumoylation; protein stabilization; molecular association, regulation; intracellular localization; protein conformation; phosphorylation carcinogenesis, induced; apoptosis, altered; signaling pathway regulation; transcription, altered; autophagy, induced; apoptosis, inhibited; cytoskeletal reorganization; transcription, inhibited; cell growth, altered p53(INDUCES); HSF1(DISRUPTS); hnRNP D0(DISRUPTS); HSP27(DISRUPTS) 11383510; 12367505; 15581903; 18477563; 19597476; 21245386; 21989268; 23950959; 32570757; 34477462; 34516752; 34851698; 36701233 52 78 30 induces lysophagy +MAPRE1 EB1 Cytoskeletal; Motility/polarity/chemotaxis Q15691 22919 20q11.21 human S40-p 59049801 TKIEQLCsGAAYCQF CH molecular association, regulation; protein conformation cytoskeletal reorganization Restin(INDUCES); dynactin 1(INDUCES); TUBB(INDUCES) 27721984; 28039481 2 1 0 astral microtubule stability ; regulating astral microtubule stability and spindle orientation/positioning +PFKFB3 PFKFB3 Carbohydrate Metabolism - fructose and mannose; EC 2.7.1.105; EC 3.1.3.46; KINASE; Kinase, other; Motility/polarity/chemotaxis; PHOSPHATASE; Phosphatase (non-protein) Q16875 5209 10p15.1 human S269-p 58109402 QGRIGGDsGLSSRGK His_Phos_1 protein degradation; enzymatic activity, inhibited 27585591 1 1 0 +IGF2BP1 IGF2BP1 RNA-binding; Translation O42254 395953 chicken Y396-p 458348 SVSGAAPySSFMPPE molecular association, regulation; activity, inhibited cell motility, inhibited RNA(DISRUPTS) 16306994; 26317350 6 0 0 IMP-1 Y396 phosphorylation interferes with its binding to beta-actin mRNA, thereby promoting beta-actin translation.; Y396F enhanced CNC emigration +ACLY ACLY Carbohydrate Metabolism - citrate (TCA) cycle; EC 2.3.3.8; Lyase; Transferase P53396 47 17q21.2 human K17-ac 40662704 TGKELLYkFICTTSA protein degradation; molecular association, regulation cell growth, altered ARHGEF3(INDUCES) 36241648 1 1 4 +STAT1 STAT1 DNA-binding; Transcription factor P42224 6772 2q32.2 human K413-ac 459199 HLQLKEQkNAGTRTN STAT_bind molecular association, regulation; intracellular localization; phosphorylation cell growth, inhibited; apoptosis, induced; transcription, induced; signaling pathway regulation; transcription, inhibited PPAR-gamma(INDUCES); NFkB-p65(INDUCES) DNA(INDUCES); DNA(DISRUPTS) 16481475; 19171783; 21576370; 26504087 4 0 1 induces dephosphorylation STAT1, regulates STAT1-associated cytokine signaling; CD36 expression; association with NFkB inhibits NFkB-DNA binding ; inhibition of transcription and nuclear import is a result of its disruption of DNA binding, and nuclear import signal. and not acetylation +SUMO1 SUMO1 Nuclear receptor co-regulator; Ubiquitin-like modifier P63165 7341 2q33.1 human K39-sm 2358309 SEIHFKVkMTTHLKK Rad60-SLD molecular association, regulation DAXX(INDUCES) 21474068 2 1 0 +NUP98 NUP98 iso2 Motility/polarity/chemotaxis; Nucleoporin P52948-2 4928 11p15.4 human T536-p 3801389 TPTHYKLtPRPATRV intracellular localization 21335236 1 11 15 as multiple sites (13PM) mutant +Nos1 nNOS Amino Acid Metabolism - arginine and proline; EC 1.14.13.39; Oxidoreductase P29476 24598 12q16 rat S1412-p 449830 TNRLRSEsIAFIEES activity, induced; enzymatic activity, induced 11038355; 33470757 14 0 0 decreased production of peroxynitrite, MMP-9 and NLRP3; S1412D mutant displayed faster electron transfer out of the reductase domain and intrincis NO synthesis, but slower steady-state NO synthesis. +GRK1 GRK1 EC 2.7.11.14; KINASE; Kinase, protein; Protein kinase, AGC; Protein kinase, Ser/Thr (non-receptor) P28327 281457 cow T8-p 2528800 MDFGSLEtVVANSAF enzymatic activity, induced 18339619 1 0 0 in vitro +Drgx DRGX DNA-binding Q8BYH0 107751 14|14 B mouse S251-p 34371736 EGSQDKTsPTKEQSE transcription, altered 28049756 1 1 1 +PTPN7 HePTP EC 3.1.3.48; Motility/polarity/chemotaxis; PHOSPHATASE; Protein phosphatase, tyrosine (non-receptor) P35236 5778 1q32.1 human S44-p 448309 RLQERRGsNVALMLD molecular association, regulation ERK2(DISRUPTS) 10559944 3 14 31 +MAVS MAVS Adaptor/scaffold; Membrane protein, integral Q7Z434 57506 20p13 human S347-gl 1872691007 ALTNPAPsKLPINST phosphorylation 31461653 1 1 0 positively regulates phosphorylation of S442 (data from MAVS 7A mutant) +CDKN2D CDKN2D Cell cycle regulation; Inhibitor; Tumor suppressor P55273 1032 19p13.2 human S66-p 6046000 ELLKQGAsPNVQDTS Ank_2 protein degradation; molecular association, regulation; ubiquitination; protein conformation cell cycle regulation CDK6(DISRUPTS) 19063602; 29531090; 32874495 2 2 0 +MAPKAP1 Sin1 Adaptor/scaffold Q9BPZ7 79109 9q33.3 human S367-p 56676494 DGVFEEDsQIDIATV molecular association, regulation; phosphorylation apoptosis, inhibited ECT2(INDUCES) 34982576 1 2 0 induces AKT phosphorylation +BRD4 BRD4 KINASE; Kinase, protein; Protein kinase, Ser/Thr (non-receptor); Protein kinase, atypical O60885 23476 19p13.12 human R181-m1 57691844 VQAKGRGrGRKETGT carcinogenesis, induced; DNA repair, induced; cell growth, induced; transcription, induced 36475791 1 2 0 +Cdk7 CDK7 Cell cycle regulation; EC 2.7.11.22; EC 2.7.11.23; KINASE; Kinase, protein; Nuclear receptor co-regulator; Protein kinase, CMGC; Protein kinase, Ser/Thr (non-receptor) Q03147 12572 13 D1|13 53.23 cM mouse T170-p 448306 GSPNRAYtHQVVTRW Pkinase molecular association, regulation; enzymatic activity, induced CCNH(INDUCES) 7553872 5 71 91 +Lime1 LIME1 Adaptor/scaffold; Membrane protein, integral Q9EQR5 72699 2|2 H4 mouse Y261-p 463811 QGPLENVyESIKEMG LIME1 activity, induced; molecular association, regulation LYN(INDUCES); Lck(INDUCES) 14610044; 16249387 3 3 13 +EIF3F eIF3-epsilon EC 3.4.19.12; Translation; Translation initiation O00303 8665 11p15.4 human T119-p 7098400 GAARVIGtLLGTVDK JAB molecular association, regulation translation, altered; apoptosis, induced eIF3-eta(INDUCES) 19245811 1 1 0 +Pxn PXN Adaptor/scaffold; Cell adhesion; Cytoskeletal; Motility/polarity/chemotaxis Q66H76 360820 12q16 rat S126-p 450227 SFPNKQKsAEPSPTV Paxillin intracellular localization 16537926 8 28 4 necessary for formation of NGF-induced neurite extensions +Cryaa CRYA1 Chaperone; Heat shock protein P24623 24273 20p12 rat S59-p 7106328 LFRTVLDsGISELMT apoptosis, inhibited 21615407 1 3 0 induces cytoprotection against C2-ceramide and staurosporine induced cell death +ARAP3 ARAP3 GAP; GAP, ARF; Motility/polarity/chemotaxis Q8WWN8 64411 5q31.3 human Y1403-p 454957 EELEEPVyEEPVYEE molecular association, regulation carcinogenesis, altered; cell motility, altered; cell adhesion, altered SLP76(INDUCES); VAV2(INDUCES) 21076469; 22750419 3 0 0 suppresses peritoneal dissemination of scirrhous gastric carcinoma cells +SMAD1 SMAD1 DNA-binding; Transcription factor Q15797 4086 4q31.21 human K118-ub 1051005 FPFGSKQkEVCINPY MH1 protein degradation 17963781 1 2 0 +GAB1 GAB1 Adaptor/scaffold; Motility/polarity/chemotaxis Q13480 2549 4q31.21 human Y317-p 449581 PPTPGNTyQIPRTFP molecular association, regulation RASA1(INDUCES); CDK6(INDUCES) 15574420; 19881549 2 7 180 promotes HGF-induced DNA synthesis +Khdrbs1 KHDRBS1 RNA-binding Q60749 20218 4|4 D2.2 mouse T71-p 449877 PPLLPPStPGPDATV activity, induced translation, altered 12478298 1 0 0 regulates splicing +BARD1 BARD1 EC 6.3.2.-; EC 6.3.2.19; Ligase; UBIQUITIN LIGASE; Ubiquitin conjugating system; Ubiquitin ligase Q99728 580 2q35 human S148-p 455770 NSIKMWFsPRSKKVR cell cycle regulation 15855157 3 9 0 resistance to genotoxic stress (mitomycin C) +C3AR1 C3aR GPCR, family 1; Membrane protein, integral; Membrane protein, multi-pass; Receptor, GPCR Q16581 719 12p13.31 human S470-p 27145807 TRSTHCPsNNVISER receptor desensitization, induced; molecular association, regulation transcription, inhibited ARRB2(INDUCES) 23077507 1 3 0 +Slc1a2 GLT1 Membrane protein, integral; Membrane protein, multi-pass; Transporter; Transporter, SLC family P31596 29482 3q32 rat K526-ub 3884553 QSVYDDTkNHRESNS receptor internalization, induced; protein degradation 18805448 1 1 3 +CDK5 CDK5 Cell cycle regulation; EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, CMGC; Protein kinase, Ser/Thr (non-receptor) Q00535 1020 7q36.1 human S47-p 1255792403 DDEGVPSsALREICL Pkinase molecular association, regulation; enzymatic activity, inhibited cell growth, induced; cell motility, inhibited CDK5R1(DISRUPTS) 30217452 1 1 0 +NCF1 p47phox EC 1.-.-.-; Oxidoreductase P14598 653361 7q11.23 human S370-p 451730 PAVPPRPsADLILNR p47_phox_C activity, induced; molecular association, regulation; intracellular localization; enzymatic activity, induced; phosphorylation signaling pathway regulation CYBA(INDUCES) 12056906; 22460559; 9857051 11 0 0 regulates ERK1/2 phosphorylation in cells treated with TNF-alpha +MYC Myc DNA-binding; Nucleolus; Oncoprotein; Transcription factor P01106 4609 8q24.21 human S308-p 10852562 GHSKPPHsPLVLKRC Myc_N protein stabilization 25006129 1 15 6 +Cdkn1a p21Cip1 Cell cycle regulation; Inhibitor P39689 12575 17 A3.3|17 15.12 cM mouse S141-p 447836 GRKRRQTsLTDFYHS protein stabilization; intracellular localization; activity, inhibited 21791608; 24848107 10 1 0 localized to cytoplasm +IKBKB IKKB EC 2.7.11.10; KINASE; Kinase, protein; Protein kinase, Other; Protein kinase, Ser/Thr (non-receptor) O14920 3551 8p11.21 human K147-ub 37036401 RIIHRDLkPENIVLQ Pkinase activity, induced; phosphorylation signaling pathway regulation 25486864 2 2 0 increases STAT3 phosphorylation, activation and signaling +DGKD DGKD EC 2.7.1.107; Kinase, lipid; Lipid Metabolism - glycerolipid; Lipid Metabolism - glycerophospholipid; Motility/polarity/chemotaxis Q16760 8527 2q37.1 human S66-p 452137 MLTKQNNsFQRSKRR PH intracellular localization 15228384 1 0 0 Phosphorylation appears to disrupt translocation of DAGK to the plasma membrane. +NPHS1 NPHS1 Cell adhesion; Immunoglobulin superfamily; Membrane protein, integral O60500 4868 19q13.12 human T1125-p 18507017 QWTGERDtQSSTVST molecular association, regulation ARRB2(INDUCES) 21321125 2 0 0 PICK1 and PKCa are also in this complex +TP63 p63 iso2 DNA-binding; Transcription factor Q9H3D4-2 8626 3q28 human S66-p 451600 SSTFDALsPSPAIPS protein degradation cell growth, inhibited 23166821; 30301786 6 2 0 Anti-clonogenic effects of TGFB require S66,68 phosphorylation. +Cdc25b CDC25B EC 3.1.3.48; Motility/polarity/chemotaxis; Nuclear receptor co-regulator; PHOSPHATASE; Protein phosphatase, dual-specificity P30306 12531 2 F1|2 63.29 cM mouse S149-p 7998663 FTIKRFRsLPVRLLE M-inducer_phosp intracellular localization cell cycle regulation 21212267; 22348958 3 13 26 +MDM2 MDM2 EC 6.3.2.-; EC 6.3.2.19; Inhibitor; Ligase; NEDDYLATION LIGASE; Neddylation Ligase; Nucleolus; Oncoprotein; UBIQUITIN LIGASE; Ubiquitin conjugating system; Ubiquitin ligase Q00987 4193 12q15 human Y302-p 38546303 PEISLADyWKCTSCN zf-RanBP protein stabilization transcription, inhibited UBE2M(INDUCES) 25624478 2 0 0 stabilization of p53 levels, neddylated-P53, represses p53-mediated maspin gene expression +TRIM33 TIF1G EC 6.3.2.-; EC 6.3.2.19; KINASE; Kinase, protein; Ligase; Protein kinase, atypical; Transcription, coactivator/corepressor; UBIQUITIN LIGASE; Ubiquitin conjugating system; Ubiquitin ligase Q9UPN9 51592 1p13.2 human Y1048-p 15406627 MMKVVQVyADTQEIN Bromodomain molecular association, regulation; intracellular localization transcription, induced; signaling pathway regulation SMAD3(DISRUPTS) 30177833 1 1 1 regulates TGFB-SMAD2/3 signaling and epithelial to mesenchymal transition +DAXX DAXX Apoptosis; Nuclear receptor co-regulator; Nucleolus; Transcription, coactivator/corepressor Q9UER7 1616 6p21.32 human S178-p 1189200 AENTASQsPRTRGSR protein degradation; molecular association, regulation apoptosis, inhibited PIN1(INDUCES) 17938171 1 11 2 +FZR1 FZR1 UBIQUITIN LIGASE; Ubiquitin conjugating system Q9UM11 51343 19p13.3 human K135-ac 1881330700 FTYSLSTkRSSPDDG protein stabilization 34244565 1 1 0 SIRT6 deacetylates and promotes degradation of FZR1 by ubiquitylation. +NCOA2 SRC-2 Motility/polarity/chemotaxis; Nuclear receptor co-regulator; Transcription, coactivator/corepressor Q15596 10499 8q13.3 human K731-sm 2793922 PGSEVTIkQEPVSPK DUF4927 molecular association, regulation; intracellular localization transcription, induced AR(INDUCES) 12060666 1 2 0 AR-dependent transcription +THRA TR-alpha DNA-binding; Nuclear receptor; Transcription factor NP_990644 396251 chicken K281-sm 27490404 LSGEMAVkREQLKNG Hormone_recep molecular association, regulation transcription, altered Src(INDUCES); N-CoR1(INDUCES) DNA(DISRUPTS) 27843805 4 0 0 +RB1 Rb Nuclear receptor co-regulator; Oncoprotein; Transcription, coactivator/corepressor; Tumor suppressor P06400 5925 13q14.2 human R787-m2 36533405 SPIPHIPrSPYKFPS Rb_C phosphorylation cell cycle regulation; transcription, inhibited 25348716 1 0 0 +PPARG PPAR-gamma DNA-binding; Nuclear receptor; Transcription factor P37231 5468 3p25.2 human Y78-p 36692605 SSISTPHyEDIPFTR PPARgamma_N protein stabilization; ubiquitination cell differentiation, induced; transcription, induced PGC-1 alpha(INDUCES) 25368164 2 1 0 inhibits ubiquitination +CACNA1C CACNA1C iso4 Channel, calcium; Membrane protein, integral; Membrane protein, multi-pass P15381-4 rabbit S1512-p 460572 DYLTRDWsILGPHHL Ion_trans activity, induced 16820363 5 1 0 +Gckr GCKR Inhibitor; Mitochondrial Q91X44 231103 5 B1|5 17.27 cM mouse S481-p 1873175600 QKFQRELsTKWVLNT molecular association, regulation HK1(INDUCES) 34001623 1 0 0 iinteraction with HK1 inhibits HK1 activity and glycolysis +BIRC5 Survivin Apoptosis O15392 332 17q25.3 human T48-p 18451300 AGFIHCPtENEPDLA BIR molecular association, regulation; intracellular localization cell cycle regulation; apoptosis, altered Borealin(DISRUPTS) 21252625 1 0 0 +Etv1 ETV1 DNA-binding; Oncoprotein; Transcription factor P41164 14009 12 A3|12 17.99 cM mouse S94-p 3059606 KIKKEPHsPCSELGS ETS_PEA3_N activity, induced transcription, induced; signaling pathway regulation 22586091 2 0 0 +MRE11 MRE11A Cell cycle regulation; DNA repair, damage; DNA-binding; Deoxyribonuclease P49959 4361 11q21 human R576-m2 62978402 GRGRGRGrRGGRGQN DNA repair, altered 15741314 0 1 0 +Thrb TR-beta1 DNA-binding; Nuclear receptor P37242 21834 14|14 A2 mouse K146-sm 27490403 LHPSYSCkYEGKCII zf-C4 molecular association, regulation; intracellular localization transcription, altered 34237030 3 0 0 recruitment of transcription factors; thyroid hormone content; normal TSH feedback regulation and TH synthesis +Eef1a1 EEF1A1 Nucleolus; Translation; Translation elongation P62630 171361 8q31 rat K165-m1 8113920 TEPPYSQkRYEEIVK GTP_EFTU molecular association, regulation translation, altered EEF1D(DISRUPTS); eEF1B(DISRUPTS); EEF1G(DISRUPTS) 28108655 2 8 46 +Brsk2 BRSK2 EC 2.7.11.1; EC 2.7.11.26; KINASE; Kinase, protein; Protein kinase, CAMK; Protein kinase, Ser/Thr (non-receptor) Q69Z98 75770 7|7 F5 mouse S468-p 4734921 PNPTPPSsPSVGGVP protein stabilization; enzymatic activity, inhibited; phosphorylation 23790753 1 1 1 inhibits axon branching (activated in BRSK2 18A mutant) +CAV1 caveolin-1 Adaptor/scaffold; Motility/polarity/chemotaxis; Nuclear receptor co-regulator P33724 403980 dog Y14-p 448422 VDSEGHLyTVPIREQ molecular association, regulation cell motility, induced; cell adhesion, induced 27259249 55 45 830 persistency and directionality, cell spreading, metastasis, specific ECM-integrin (beta1) interactions and Y14 phosphorylation are necessary +FOXA2 FOXA2 DNA-binding; Transcription factor Q9Y261 3170 20p11.21 human S111-p 22825101 PHLSPSLsPLGGQAA Forkhead_N carcinogenesis, induced; cell growth, induced; transcription, inhibited; signaling pathway regulation 22196886 1 1 0 +IRF3 IRF3 DNA-binding; Transcription factor Q14653 3661 19q13.33 human S97-p 51637401 LRLAEDRsKDPHDPH IRF molecular association, regulation; intracellular localization transcription, inhibited KPNA2(DISRUPTS) 32130408; 34804040; 35948267 4 2 0 +Grm1 mGluR1 GPCR, family 3; Membrane protein, integral; Membrane protein, multi-pass; Receptor, GPCR P23385 24414 1p13 rat T871-p 4713375 KLPCRSNtFLNIFRR receptor desensitization, induced; molecular association, regulation CAMK2A(INDUCES) 23426668 1 2 3 +TH TH iso3 Amino Acid Metabolism - tyrosine; EC 1.14.16.2; Endoplasmic reticulum; Mitochondrial; Oxidoreductase; Vesicle P07101-3 7054 11p15.5 human S31-p 448544 KQAEAIMsPRFIGRR TOH_N molecular association, regulation; intracellular localization; enzymatic activity, induced; phosphorylation SLC18A2(INDUCES); SNCA(INDUCES) 19833152; 28637871; 7901013; 9920892 43 8 0 absence of S31 and S40 in an alternative spliced variant lacking exon 3 that has reduced enzymatic activity in vitro +PELP1 PELP1 Nuclear receptor co-regulator; Transcription, coactivator/corepressor Q8IZL8 27043 17p13.2 human S1033-p 472322 LAPEALPsQGEVERE DNA repair, induced; apoptosis, inhibited; transcription, induced; transcription, inhibited 24786831; 25788226 2 14 29 modulate levels of E2F1 +HTATSF1 TAT-SF1 Spliceosome; Transcription, coactivator/corepressor O43719 27336 Xq26.3 human S748-p 18016601 GSSFILSsDDDDDDI molecular association, regulation carcinogenesis, induced; DNA repair, induced TOPBP1(INDUCES) 35597237 1 3 0 +H2BC3 H2B DNA-binding P33778 3018 6p22.2 human S36-p 449903 RKRSRKEsYSIYVYK Histone methylation cell differentiation, induced; transcription, inhibited 27151441 7 13 47 enriched presence of EZH2 and H3K27me3 at Wnt gene promoters, suppresses the expression of Wnt genes +CDC6 CDC6 Cell cycle regulation Q99741 990 17q21.2 human S74-p 450915 TPHLPPCsPPKQGKK protein stabilization; molecular association, regulation; intracellular localization cell cycle regulation CDH1(DISRUPTS) 10339564; 16153703; 22179839; 23129444; 24216307; 27246979; 9889196 7 11 1 +TEX14 TEX14 Cancer Testis Antigen (CTA); KINASE; Kinase, protein; Protein kinase, Other; Protein kinase, Ser/Thr (non-receptor) Q8IWB6 56155 17q22 human T728-p 25158901 NLNNMSTtEEYLISK molecular association, regulation; intracellular localization PLK1(INDUCES) 22405274 1 0 0 +Camk2b CAMK2B EC 2.7.11.17; KINASE; Kinase, protein; Protein kinase, CAMK; Protein kinase, Ser/Thr (non-receptor) P08413 24245 14q21 rat T320-p 48915800 NFSVGRQtTAPATMS molecular association, regulation 26291163 1 1 0 inhibits interaction with F-actin, regulates synaptic plasticity +PER2 PER2 Nuclear receptor co-regulator; Nucleolus; Transcription factor O15055 8864 2q37.3 human S696-p 468399 EMVEDAAsGPESLDC carcinogenesis, induced; cell growth, induced 30746467 2 6 0 +USO1 TAP Motility/polarity/chemotaxis; Vesicle O60763 8615 4q21.1 human S942-p 450465 EEEDELEsGDQEDED Uso1_p115_C intracellular localization 9478999 3 69 42 regulates association with Golgi membrane +SGO1 SGO1 Cell cycle regulation Q5FBB7 151648 3p24.3 human S507-p 486242 TDLCFLNsPIFKQKK chromatin organization, altered 17621308 1 12 5 required for proper association between the kinetochore and spindle microtubules +Ace2 ACE2 EC 3.4.17.23; Membrane protein, integral; Protease Q8R0I0 70008 X F5|X 76.12 cM mouse S680-p 1868162500 SDLKPRVsFYFFVTS Collectrin protein stabilization 29570986; 32755395 3 0 0 +LIG1 LIG1 DNA repair, damage; EC 6.5.1.1; Ligase P18858 3978 19q13.33 human S76-p 449246 EEEDEALsPAKGQKP molecular association, regulation; intracellular localization cell growth, altered RFC1(INDUCES); RAD17(DISRUPTS) 12851383; 19223468 6 54 7 regulates DNA replication and repair +AHSA1 AHSA1 Chaperone O95433 10598 14q24.3 human Y223-p 3914778 LTSPEELyRVFTTQE AHSA1 protein degradation; molecular association, regulation; ubiquitination HSP90A(INDUCES) 26235616; 29127155 3 3 6 displaces Tsc1 from Hsp90; increases chaperone activity and reduces expression of CFTR +Ripk3 RIPK3 EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, Ser/Thr (non-receptor); Protein kinase, TKL Q9QZL0 56532 14|14 C3 mouse K469-ub 1883588008 TTASSSAkYDQAQFG activity, induced; ubiquitination apoptosis, inhibited 35800780 1 1 0 Loss of RIPK3-K359 ubiquitin modification prevents increased RIPK3-K469R killing activity, RIPK3-K469ub can restrict cell death by preventing upstream ubiquitylation on K359; activated RIPK3 transitions into a TX-100-insoluble compartmemt, RIPK3 K469 ubiquitylation to limit its cell death-inducing activity, Ripk3 K469R/K469R mice display a moderately reduced capacity to clear Salmonella infection +ACLY ACLY Carbohydrate Metabolism - citrate (TCA) cycle; EC 2.3.3.8; Lyase; Transferase P53396 47 17q21.2 human Y1006-p 1868989001 PATPLLDyALEVEKI Citrate_synt acetylation; enzymatic activity, induced carcinogenesis, induced 32420483 1 0 0 +HASPIN Haspin EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, Other; Protein kinase, Ser/Thr (non-receptor) Q8TF76 83903 17p13.2 human T128-p 3952695 RPPQKCStPCGPLRL molecular association, regulation; phosphorylation cell cycle regulation PLK1(INDUCES) 24413556 1 1 7 Haspin phosphorylation at PLK1 sites +ABI1 Abi-1 Adaptor/scaffold; Motility/polarity/chemotaxis Q8IZP0 10006 10p12.1 human S225-p 1983922 ARLGSQHsPGRTASL molecular association, regulation cell motility, induced; cell motility, altered; cytoskeletal reorganization 21419341; 35293964 2 51 103 +MAP2K4 MKK4 EC 2.7.12.2; KINASE; Kinase, protein; Protein kinase, STE; Protein kinase, dual-specificity (non-receptor) P45985 6416 17p12 human S257-p 447654 ISGQLVDsIAKTRDA Pkinase enzymatic activity, induced 9162092 14 16 45 +PTPRE PTPRE EC 3.1.3.48; Membrane protein, integral; Motility/polarity/chemotaxis; PHOSPHATASE; Receptor protein phosphatase, tyrosine P23469 5791 10q26.2 human N30-ng 1871141701 NETTADSnETTTTSG phosphorylation 31722979 1 0 0 mutants decrease phosphorylation +Ikzf1 Ikaros C2H2-type zinc finger protein; DNA-binding; Transcription factor Q03267 22778 11 A1|11 7.02 cM mouse S167-p 451355 LRHIKLHsGEKPFKC intracellular localization 12464629 2 3 0 +Foxo3 FOXO3A Autophagy; DNA-binding; Oncoprotein; Transcription factor Q9WVH4 56484 10 B2|10 22.79 cM mouse S293-p 472326 QLSKWPGsPTSRSSD transcription, inhibited 27875304 5 19 63 +MAPK7 ERK5 EC 2.7.11.24; KINASE; Kinase, protein; Protein kinase, CMGC; Protein kinase, Ser/Thr (non-receptor) Q13164 5598 17p11.2 human S754-p 21560206 LEEFLNQsFDMGVAD intracellular localization transcription, induced 29483645 1 1 0 oncogenic BRAF induced nuclear localization and transcription +LRRK2 LRRK2 EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, Ser/Thr (non-receptor); Protein kinase, TKL Q5S007 120892 12q12 human T2524-p 15785717 LAEKMRRtSVE____ molecular association, regulation 14-3-3 beta(INDUCES); 14-3-3 sigma(INDUCES); 14-3-3 theta(INDUCES); 14-3-3 zeta(INDUCES); 14-3-3 epsilon(INDUCES); 14-3-3 gamma(INDUCES); 14-3-3 eta(INDUCES) 32317922 2 1 0 +POLD3 POLD3 DNA replication; Nucleotide Metabolism - purine; Nucleotide Metabolism - pyrimidine Q15054 10714 11q13.4 human S458-p 3196808 GKANRQVsITGFFQR CDC27 molecular association, regulation; enzymatic activity, altered PCNA(DISRUPTS) 22148433 1 21 27 S458D mutation results in a loss of POLD3 (aka p68) processivity +TBK1 TBK1 EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, Other; Protein kinase, Ser/Thr (non-receptor) Q9UHD2 29110 12q14.2 human Y354-p 3437786 SSNQELIyEGRRLVL TBK1_ULD enzymatic activity, inhibited; protein conformation 28618271 1 2 1 suppress antiviral defenses +MISP MISP Unknown function Q8IVT2 126353 19p13.3 human S400-p 3205362 LSSDSILsPAPDARA AKAP2_C cytoskeletal reorganization 34023777 1 22 22 +DIAPH2 Diaphanous-2 iso4 Cytoskeletal; Motility/polarity/chemotaxis Q17R91 1730 Xq21.33 human T882-p 18707507 KSADQKTtLLHFIAD FH2 cell cycle regulation; chromatin organization, altered; cytoskeletal reorganization 21397845 1 1 0 mutation of this site disrupts metaphase chromosome alignment +NR1I2 PXR DNA-binding; Nuclear receptor O75469 8856 3q13.33 human S208-p 9730703 QVRKDLCsLKVSLQL molecular association, regulation transcription, altered N-CoR1(INDUCES); FGR(DISRUPTS); RXRA(DISRUPTS) 19617467 1 0 0 inhibits transcription +Kcnj11 Kir6.2 Channel, potassium; Membrane protein, integral; Membrane protein, multi-pass Q61743 16514 7 B3|7 29.66 cM mouse T341-p 2103600 GNTIKVPtPLCTARQ IRK_C activity, induced; protein conformation 18280666 1 0 0 +App APP iso2 Apoptosis; Cell surface; Membrane protein, integral; Receptor, misc.; Transcription factor P12023-2 11820 16 C3.3|16 46.92 cM mouse Y682-p 448202 SKMQQNGyENPTYKF APP_amyloid molecular association, regulation GRB2(INDUCES); SHC1(INDUCES) 15054097; 27325702 14 20 864 +HNRNPC hnRNP C1/C2 RNA splicing; RNA-binding; Spliceosome P07910 3183 14q11.2 human S260-p 448833 SEGGADDsAEEGDLL molecular association, regulation RNA(NOT_REPORTED) 15687492 2 75 87 +PLIN2 perilipin 2 Endoplasmic reticulum Q99541 123 9p22.1 human Y232-p 1873650100 TKLHSRAyQQALSRV Perilipin protein degradation; molecular association, regulation autophagy, induced; cell growth, induced; apoptosis, inhibited HSC70(INDUCES) 34077757 1 1 0 +SREBF1 SREBP-1 DNA-binding; Membrane protein, integral; Membrane protein, multi-pass; Transcription factor P36956 6720 17p11.2 human T426-p 467200 TEVEDTLtPPPSDAG protein degradation; molecular association, regulation; ubiquitination; phosphorylation transcription, induced FBXW7(INDUCES) 16825193; 19126544; 22384276; 26759235 6 3 0 +PRKD1 PRKD1 Autophagy; EC 2.7.11.13; KINASE; Kinase, protein; Motility/polarity/chemotaxis; Protein kinase, CAMK; Protein kinase, Ser/Thr (non-receptor) Q15139 5587 14q12 human S219-p 455755 VSTIRTSsAELSTSA molecular association, regulation 14-3-3 beta(INDUCES) 15755722 1 3 0 +SMAD3 SMAD3 DNA-binding; Nuclear receptor co-regulator; Transcription factor P84022 4088 15q22.33 human T179-p 451177 PQSNIPEtPPPGYLS molecular association, regulation; intracellular localization; activity, inhibited cell cycle regulation; carcinogenesis, induced; cell motility, induced; transcription, induced; signaling pathway regulation; transcription, altered; transcription, inhibited; cell growth, altered NEDD4L(INDUCES); PIN1(INDUCES) 10197981; 15241418; 16156666; 19914168; 19917253; 19920136; 20736297; 26297431; 33051597 15 0 0 TGF-beta induced epithelial-to-mesenchymal transition (EMT) ; TGFB1 signaling +MYH7 MYH7 Motility/polarity/chemotaxis; Motor P12883 4625 14q11.2 human K34-ac 15292419 QTRPFDLkKDVFVPD Myosin_N protein conformation 35502901 0 1 56 +Vasp VASP Cytoskeletal; Motility/polarity/chemotaxis P70460 22323 7|7 A3 mouse S153-p 448379 EHMERRVsNAGGPPA molecular association, regulation cytoskeletal reorganization ACTB(DISRUPTS); Abl iso4(INDUCES) 12087107; 21795685 55 4 0 Abolishes actin polymerization +Dlc1 DLC1 GAP; GAP, Rac/Rho; Tumor suppressor Q9R0Z9 50768 8 A4|8 23.05 cM mouse S432-p 15500000 KELKRRNsSSSLSSR activity, induced; molecular association, regulation; activity, inhibited carcinogenesis, inhibited; cell growth, inhibited; cytoskeletal reorganization; cell motility, inhibited tensin 2(INDUCES); DLC1(INDUCES) 23511482 2 5 2 Increased GAP activity further inhibiting RhoA activity +CALD1 Caldesmon Actin-binding P12957 373965 chicken S631-p 15668100 AHTTAVVsKIDSRLE Caldesmon molecular association, regulation Caldesmon(DISRUPTS) 20858431 0 3 0 enhances effect of S672 and S702 phosphorylation to weaken interaction +Ncf1 p47phox EC 1.-.-.-; Oxidoreductase Q09014 17969 5 G2|5 74.47 cM mouse S329-p 449404 QDTYRRNsVRFLQQR NECFESHC intracellular localization; enzymatic activity, induced 30483268 22 0 0 NADPH oxidase activation and superoxide production induced further aggravating liver I/R injury +Neurod1 NEUROD1 DNA-binding; Transcription factor Q60867 18012 2 C3|2 47.58 cM mouse S274-p 465680 PSFDGPLsPPLSING Neuro_bHLH molecular association, regulation transcription, induced E2A iso2(INDUCES) 12810726 3 0 0 +Drgx DRGX DNA-binding Q8BYH0 107751 14|14 B mouse T110-p 62925706 KEPMAEVtPPPVRNI protein conformation transcription, altered 28049756 1 1 0 +Git1 GIT1 GAP; GAP, ARF; Motility/polarity/chemotaxis Q9Z272 83709 10q24 rat Y293-p 15702201 EELAMDVyDEVDRRE GIT_SHD molecular association, regulation eNOS(INDUCES) 24764294 4 1 0 +GPKOW GPKOW RNA-binding Q92917 27238 Xp11.23 human S27-p 10405008 SFGFTRTsARRRLAD molecular association, regulation RNA(DISRUPTS) 21880142 1 2 1 regulates pre-mRNA processing +HDAC2 HDAC2 DEACETYLASE; Deacetylase; EC 3.5.1.98; Nuclear receptor co-regulator; Transcription, coactivator/corepressor Q92769 3066 6q21 human S411-p 13373500 KRISIRAsDKRIACD molecular association, regulation; acetylation; enzymatic activity, inhibited p53(INDUCES); HDAC1(INDUCES) 20388487 3 3 0 +BMAL1 BMAL1 DNA-binding; Transcription factor Q9I8T7 374115 chicken T534-p 448633 SPLNITStPPPDTSS activity, inhibited transcription, inhibited 11687575 2 0 0 +CSRP2 CSRP2 Cell development/differentiation Q16527 1466 12q21.2 human Y62-p 470027 EIYCKSCyGKKYGPK LIM intracellular localization transcription, altered 12771930 1 0 0 Nuclear translocation. +Syn1 SYN1 Vesicle P09951 24949 Xq11 rat S603-p 450236 AGPIRQAsQAGPGPR intracellular localization 19896987 21 10 11 +CAMK2D CAMK2D EC 2.7.11.17; KINASE; Kinase, protein; Protein kinase, CAMK; Protein kinase, Ser/Thr (non-receptor) Q13557 817 4q26 human T337-p 484561 STESSNTtIEDEDVK enzymatic activity, altered 34391760 1 37 5 +Naca NACA iso2 Motility/polarity/chemotaxis; Transcription, coactivator/corepressor Q60817 17938 10|10 D3 mouse K127-sm 31014809 YIVFGEAkIEDLSQQ NAC molecular association, regulation transcription, inhibited TXLNG(INDUCES); HDAC2(INDUCES) 24375853 1 0 0 +BCAR1 P130Cas Adaptor/scaffold; Motility/polarity/chemotaxis P56945 9564 16q23.1 human Y410-p 448720 GVVDSGVyAVPPPAE carcinogenesis, induced; cell motility, inhibited 35081345 18 23 126 +ATXN3 ataxin-3 DEUBIQUITINASE; DNA repair, damage; EC 3.4.19.12; Protease; Transcription regulation; Ubiquitin-specific protease P54252 4287 14q32.12 human S12-p 53998806 FHEKQEGsLCAQHCL Josephin enzymatic activity, inhibited 26880203 1 1 0 phosphorylation protects against toxicity of pathogenic pathways mediated by polyglutamine-expanded ataxin-3 +Stat3 STAT3 DNA-binding; Motility/polarity/chemotaxis; Nuclear receptor co-regulator; Transcription factor P42227 20848 11 D|11 63.82 cM mouse S727-p 448191 NTIDLPMsPRTLDSL activity, induced; molecular association, regulation; intracellular localization; phosphorylation carcinogenesis, induced; cell motility, induced; transcription, induced; signaling pathway regulation; transcription, altered; neural plasticity; cell growth, induced; cell differentiation, induced; apoptosis, inhibited; cytoskeletal reorganization; transcription, inhibited; cell growth, altered PDGFRA(INDUCES); GRIM-19(INDUCES); ANXA1(INDUCES); PIN1(INDUCES) DNA(INDUCES); DNA(DISRUPTS) 11278353; 12049654; 12684046; 14673173; 15096606; 15705584; 16205632; 16247467; 16418226; 17563747; 21575863; 21738764; 25584415; 26479789; 26573296; 27050520; 28356390; 33788814; 34124936; 34380027; 34507993; 35732128; 35806005; 35986103; 36688918; 37440406 227 57 67 regulates IFN signaling +FOXO4 FOXO4 DNA-binding; Oncoprotein; Transcription factor P98177 4303 Xq13.1 human S265-p 231166707 PRSSSNAsSVSTRLS protein degradation; phosphorylation 28945225 1 0 0 26 S proteasome-mediated FOXO4 proteolysis in the nuclei of RAS mutant colon cancer cells +CDC25A CDC25A EC 3.1.3.48; Motility/polarity/chemotaxis; PHOSPHATASE; Protein phosphatase, dual-specificity P30304 993 3p21.31 human S279-p 449129 VLKRPERsQEESPPG M-inducer_phosp protein degradation 12676583 1 0 0 +SIAH2 SIAH2 EC 6.3.2.-; EC 6.3.2.19; Ligase; Transcription, coactivator/corepressor; UBIQUITIN LIGASE; Ubiquitin conjugating system; Ubiquitin ligase O43255 6478 3q25.1 human T279-p 1872043500 RRLTWEAtPRSIHDG Sina protein stabilization carcinogenesis, induced; cell motility, induced; cell growth, induced 33536006 1 0 0 +PTK2 FAK EC 2.7.10.2; KINASE; Kinase, protein; Protein kinase, TK; Protein kinase, tyrosine (non-receptor) Q00944 396416 chicken S722-p 447962 PSRPGYPsPRSSEGF molecular association, regulation; enzymatic activity, inhibited cell motility, altered PPP1CA(INDUCES); P130Cas(DISRUPTS) 11160818; 15975092 9 18 0 +HRH1 H1R GPCR, family 1; Membrane protein, integral; Membrane protein, multi-pass; Receptor, GPCR P35367 3269 3p25.3 human S396-p 453404 FTWKRLRsHSRQYVS 7tm_1 receptor desensitization, altered; activity, inhibited 15107581; 15328002 2 0 0 S396 phosphorylation had an inhibitory effect on S398-mediated receptor downregulation. +GAD2 GAD2 Amino Acid Metabolism - alanine, aspartate and glutamate; Carbohydrate Metabolism - butanoate; EC 4.1.1.15; Lyase; Other Amino Acids Metabolism - beta-alanine; Other Amino Acids Metabolism - taurine and hypotaurine Q05329 2572 10p12.1 human S6-p 12523303 __MASPGsGFWSFGS enzymatic activity, induced transcription, induced 31182548 2 1 0 +Gli2 GLI2 C2H2-type zinc finger protein; Oncoprotein; Transcription factor Q0VGT2 14633 1 E2.3|1 52.17 cM mouse K716-sm 25352003 VHRFEQLkREKLKSL molecular association, regulation transcription, inhibited HDAC5(INDUCES) 22549777 1 0 0 +Ikbkg IKKG Adaptor/scaffold; Protein kinase, regulatory subunit O88522 16151 X|X A7.3 mouse S369-p 448798 LPAPAHHsFHLALSN activity, inhibited transcription, induced; transcription, altered 11971901; 36309088 5 2 6 +H3c1 H3 DNA-binding P68433 360198 13|13 A3.1 mouse K27-me 467241 LATKAARkSAPATGG Histone transcription, inhibited 19233846 11 3 0 p16 Ink4a/ p19Arf locus +MYBPC3 MYBPC3 Myosin-binding Q14896 4607 11p11.2 human S275-p 471079 LSAFRRTsLAGGGRR cytoskeletal reorganization 20018870 25 9 14 regulation of cardiac myofilament function +APP APP Apoptosis; Cell surface; Membrane protein, integral; Receptor, misc.; Transcription factor P05067 351 21q21.3 human K687-ne 12124805 GYEVHHQkLVFFAED Beta-APP transcription, inhibited Fe65(DISRUPTS) 18096514 1 0 0 +FOSL1 FRA1 DNA-binding; Transcription factor P15407 8061 11q13.1 human K116-ac 40663031 RVRRERNkLAAAKCR bZIP_1 molecular association, regulation cell growth, inhibited; transcription, inhibited DNA(DISRUPTS) 30804456 1 0 5 NANOG is a key downstream effector of IL-6/STAT3/FRA1 +Pfkfb2 PFKFB2 Carbohydrate Metabolism - fructose and mannose; EC 2.7.1.105; EC 3.1.3.46; Kinase, other; Motility/polarity/chemotaxis; Phosphatase (non-protein) Q9JJH5 24640 13q13 rat S469-p 448460 PVRMRRNsFTPLSSS enzymatic activity, induced 11069105 10 60 333 +Kcnj11 Kir6.2 Channel, potassium; Membrane protein, integral; Membrane protein, multi-pass Q61743 16514 7 B3|7 29.66 cM mouse S372-p 22874702 RGPLRKRsVAVAKAK receptor internalization, induced 22207763 1 2 0 Kir6.2\SUR2B channels activity inhibited +PLEK pleckstrin Lipid-binding P08567 5341 2p14 human S117-p 451306 ARKSTRRsIRLPETI activity, induced 7559487 2 13 146 +SMARCC2 SMARCC2 DNA-binding; Transcription, coactivator/corepressor Q8TAQ2 6601 12q13.2 human S969-p 15707400 PPALPPGsQPIPPTG molecular association, regulation chromatin organization, altered MCPH1(INDUCES) 19525936 1 0 0 interaction enhanced after DNA damage with ionizing radiation +Trhr TRHR GPCR, family 1; Membrane protein, integral; Membrane protein, multi-pass; Receptor, GPCR Q01717 25570 7q31 rat T371-p 465593 STELDDItVTDTYVS receptor internalization, altered 11278484 3 0 0 S383, T365, T371 are important for the receptor internalization +LYN LYN EC 2.7.10.2; KINASE; Kinase, protein; Oncoprotein; Protein kinase, TK; Protein kinase, tyrosine (non-receptor) P07948 4067 8q12.1 human Y508-p 447624 YTATEGQyQQQP___ molecular association, regulation; enzymatic activity, inhibited; enzymatic activity, induced carcinogenesis, induced; cell growth, induced; apoptosis, inhibited STAT3(INDUCES); PAG(INDUCES) 15626731; 18070987 27 48 1560 +Braf BRAF EC 2.7.11.1; KINASE; Kinase, protein; Oncoprotein; Protein kinase, Ser/Thr (non-receptor); Protein kinase, TKL F1M9C3 114486 4q22 rat S463-p 447803 PQRERKSsSSSSSTE enzymatic activity, inhibited; enzymatic activity, induced cell differentiation, altered 17074813 7 1 32 activates the B3-Raf9b isoform ; inhibits activity of the B2-Raf8b isoform +FYN Fyn EC 2.7.10.2; KINASE; Kinase, protein; Oncoprotein; Protein kinase, TK; Protein kinase, tyrosine (non-receptor) P06241 2534 6q21 human Y420-p 447882 RLIEDNEyTARQGAK PK_Tyr_Ser-Thr molecular association, regulation carcinogenesis, induced; DNA repair, induced STEP(INDUCES) 11983687; 29989005 31 94 3048 +IFNAR1 IFNAR1 Membrane protein, integral; Receptor, cytokine P17181 3454 21q22.11 human Y466-p 450029 VFLRCINyVFFPSLK protein stabilization; molecular association, regulation; receptor internalization, inhibited; phosphorylation transcription, induced STAT2(INDUCES); STAT1(INDUCES) 12220192; 23129613; 8605876; 9121453 5 0 0 virally induced and negatively regulated by PTP1B dephosphorylatyion of human Y466 +CLOCK CLOCK ACETYLTRANSFERASE; Acetyltransferase; DNA-binding; EC 2.3.1.48; Transcription factor O15516 9575 4q12 human K842-sm 27992506 DSLPDPSkVQPQ___ molecular association, regulation cell cycle regulation; cell growth, induced; transcription, induced; signaling pathway regulation ER-alpha(INDUCES) 23160374 1 0 0 induces ER-alpha signaling +IRF3 IRF3 DNA-binding; Transcription factor Q14653 3661 19q13.33 human S123-p 4712212 DFSQPDTsPDTNGGG molecular association, regulation transcription, inhibited IRF7(INDUCES) 23685991; 24275658 2 11 0 Formation of IRF3:IRF7 dimers +Plcg2 PLCG2 Carbohydrate Metabolism - inositol phosphate; EC 3.1.4.11; Motility/polarity/chemotaxis; Phospholipase P24135 29337 19q12 rat Y1197-p 447938 LESEEELySSCRQLR enzymatic activity, induced 11507089 4 1 87 +PYGM PYGM Carbohydrate Metabolism - starch and sucrose; EC 2.4.1.1; Endoplasmic reticulum; Phosphorylase; Transferase P00489 100008972 rabbit S15-p 449838 QEKRKQIsVRGLAGV enzymatic activity, induced 270711; 5442160 5 7 1 +EHD3 EHD3 Q9NZN3 30845 2p23.1 human K315-sm 49176400 AYIISSLkKEMPSVF DUF5600 receptor recycling, induced; intracellular localization endocytosis, altered 26226295 1 0 0 tubulation of the endocytic recycling compartment (ERC) membranes and efficient recycling +Insr INSR EC 2.7.10.1; KINASE; Kinase, protein; Membrane protein, integral; Protein kinase, TK; Protein kinase, tyrosine (receptor) P15127 24954 12p12 rat T1188-p 14574883 MTRDIYEtDYYRKGG PK_Tyr_Ser-Thr enzymatic activity, inhibited; phosphorylation signaling pathway regulation 33411692 1 4 52 inhibits PDE3B activity, induces PKA activity, induces phosphorylation of perilipin, HSL, and ATGL, leads to insulin resistance +RASSF1 RASSF1 iso2 Tumor suppressor Q9NS23-2 11186 3p21.31 human T202-p 483999 GTSVRRRtSFYLPKD RA protein degradation; molecular association, regulation; ubiquitination cell cycle regulation TUBA1A(DISRUPTS) 17563743; 21874044 2 3 1 APC/C-dependent ubiquitination of RASSF1 +EIF2S2 eIF2-beta Translation; Translation initiation P20042 8894 20q11.22 human S67-p 450072 DTRKKDAsDDLDDLN translation, altered; cell growth, altered 16225457 3 38 0 +DBN1 DBN1 iso3 Actin-binding; Cytoskeletal; Motility/polarity/chemotaxis Q16643-3 1627 5q35.3 human S342-p 485840 SSSSSSSsPPRTPFP intracellular localization cytoskeletal reorganization 24637538 1 9 0 Phospho-drebrin was localized at the distal part of total drebrin in the growth cone. +MARK3 MARK3 EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, CAMK; Protein kinase, Ser/Thr (non-receptor) P27448 4140 14q32.32-q32.33 human T211-p 450314 TVGGKLDtFCGSPPY Pkinase enzymatic activity, induced 12879020 3 46 34 +TCF7L2 TCF7L2 Apoptosis; Cell cycle regulation; Cell development/differentiation; DNA-binding; Motility/polarity/chemotaxis; Transcription factor Q9NQB0 6934 10q25.2-q25.3 human T201-p 11499003 PHHVHPLtPLITYSN CTNNB1_binding molecular association, regulation DNA(DISRUPTS) 12556497 1 0 0 Beta-catenin-TCF7L2 complex DNA binding +Ybx1 YB-1 RNA processing; RNA splicing; RNA-binding; Transcription factor P62961 500538 5q36 rat S100-p 455636 NPRKYLRsVGDGETV CSD intracellular localization transcription, induced 27080258 23 33 2 nuclear localization, Phospho-YB-1(Ser100) is necessary for expression of select FSH target genes +WWTR1 TAZ Oncoprotein; Transcription, coactivator/corepressor Q9GZV5 25937 3q25.1 human S105-p 3211881 TGAGAAGsPAQQHAH protein degradation; activity, inhibited carcinogenesis, inhibited; cell growth, inhibited; cell motility, inhibited; transcription, inhibited 26183396; 26375055 2 6 13 +Sox2 SOX2 Cell development/differentiation; DNA-binding; Transcription factor P48432 20674 3 A3|3 16.93 cM mouse K75-ac 8537503 MHNSEISkRLGAEWK HMG_box protein degradation; molecular association, regulation; ubiquitination; intracellular localization transcription, altered Exportin-1(INDUCES) 19591226 1 1 1 promotes nuclear export +Stat2 STAT2 DNA-binding; Transcription factor Q9WVL2 20847 10 D3|10 76.5 cM mouse T403-p 1869973803 IWDFGFLtLVEQRAV STAT_bind signaling pathway regulation 32759968 2 1 0 IFN-1 signaling; regulates antiviral defense +Lime1 LIME1 Adaptor/scaffold; Membrane protein, integral Q9EQR5 72699 2|2 H4 mouse Y242-p 454608 PLGSDVEyEAINLRG LIME1 activity, induced; molecular association, regulation LYN(INDUCES); Lck(INDUCES) 14610044; 16249387 3 1 17 +Dapk2 DAPK2 EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, CAMK; Protein kinase, Ser/Thr (non-receptor) Q8VDF3 13143 9 C|9 35.75 cM mouse T369-p 487231 HPRRRSStS______ molecular association, regulation 14-3-3 epsilon(INDUCES); 14-3-3 gamma(INDUCES) 26047703 2 1 1 +Epha4 EphA4 EC 2.7.10.1; KINASE; Kinase, protein; Membrane protein, integral; Protein kinase, TK; Protein kinase, tyrosine (receptor) Q03137 13838 1 C4|1 39.55 cM mouse Y779-p 450858 EDDPEAAyTTRGGKI PK_Tyr_Ser-Thr enzymatic activity, induced cell cycle regulation; cell motility, altered 10848605; 18515860 2 33 700 +MAVS MAVS Adaptor/scaffold; Membrane protein, integral Q7Z434 57506 20p13 human K311-ub 89115601 PVNTVALkVPANPAS protein degradation; molecular association, regulation autophagy, induced MAVS(INDUCES) 27992402; 31304625 2 1 0 RNF34-induced K63-K27 ubiquitination transition promoting autophagic degradation of MAVS aggregates +MDM4 MDM4 EC 6.3.2.-; Ligase; UBIQUITIN LIGASE; Ubiquitin conjugating system; Ubiquitin ligase O15151 4194 1q32.1 human S367-p 457676 PDCRRTIsAPVVRPK protein degradation; protein stabilization; molecular association, regulation; ubiquitination; intracellular localization; phosphorylation transcription, induced; transcription, inhibited; cell growth, altered 14-3-3 zeta(INDUCES); 14-3-3 epsilon(INDUCES); p53(DISRUPTS); MDM2(DISRUPTS); USP7(DISRUPTS); 14-3-3 beta(INDUCES); 14-3-3 theta(INDUCES); 14-3-3 gamma(INDUCES); MDM2(INDUCES); CK1A(DISRUPTS) 15788536; 16163388; 16227609; 16511560; 16511572; 16943424; 18356162; 19432880; 19808970; 22120712; 23028042; 23277204; 24190973; 27114532 21 11 2 +SKAP1 SKAP55 Adaptor/scaffold; Motility/polarity/chemotaxis Q86WV1 8631 17q21.32 human Y298-p 460297 KGVDYASyYQGLWDC molecular association, regulation cell adhesion, altered SLP76(DISRUPTS) 16461356 1 0 0 +Pdx1 PDX1 DNA-binding; Transcription factor P52946 18609 5 G3|5 86.84 cM mouse S61-p 458401 LGSLEQGsPPDISPY protein degradation 16407209 3 1 0 +Mag MAG Cell adhesion; Membrane protein, integral P07722 29409 1q21 rat Y620-p 451280 LTEELAEyAEIRVK_ molecular association, regulation PLCG1(INDUCES); Fyn(INDUCES) 7525550 1 0 0 L-MAG but not S-MAG expressed in fibroblasts was capable of binding PLCgamma SH2 domains. +RAP1B RAP1B G protein; G protein, monomeric; G protein, monomeric, Ras P61224 5908 12q15 human S179-p 451799 PGKARKKsSCQLL__ activity, induced; molecular association, regulation; protein conformation RAP1GDS1(DISRUPTS) 19651783; 27760305 8 1 0 inhibits the prenylation of Rap1B +MAP2K1 MEK1 EC 2.7.12.2; KINASE; Kinase, protein; Protein kinase, STE; Protein kinase, dual-specificity (non-receptor) P29678 100009316 rabbit S218-p 448514 VSGQLIDsMANSFVG Pkinase enzymatic activity, induced 7873542 124 13 83 in vitro +MYLK smMLCK EC 2.7.11.18; KINASE; Kinase, protein; Protein kinase, CAMK; Protein kinase, Ser/Thr (non-receptor) P29294 100009143 rabbit S1005-p 455821 GLSGRKSsTGSPTSP activity, induced; intracellular localization 11346659; 12176732 7 17 8 +KAT5 Tip60 ACETYLTRANSFERASE; Acetyltransferase; EC 2.3.1.48; Nuclear receptor co-regulator; Nucleolus Q92993 10524 11q13.1 human K189-ac 52498001 AQPGRKRkSNCLGTD protein degradation; intracellular localization apoptosis, altered 25301942 1 0 0 HDAC3 increased the TIP60 half-life, and the ubiquitination level of TIP60, nuclear localization, cytoplasm and nucleus with HDAC3 expressed, TIP60 deacetylation increases its resistance to apoptosis +CAV2 caveolin-2 Adaptor/scaffold; Motility/polarity/chemotaxis P51636 858 7q31.2 human S36-p 469561 DPEKFADsDQDRDPH Caveolin activity, induced 12743374 3 7 4 formation of caveolae +CFTR CFTR Channel, chloride; EC 3.6.3.49; Hydrolase; Membrane protein, integral; Membrane protein, multi-pass; Transporter; Transporter, ABC family P13569 1080 7q31.2 human T1471-p 21440502 IAALKEEtEEEVQDT protein degradation; intracellular localization; activity, inhibited 21930781 2 1 0 Regulates CFTR trafficking +Bach2 BACH2 DNA-binding; Transcription factor P97303 12014 4|4 A5 mouse K275-sm 2798317 GLPMGQIkSEPPSEE intracellular localization transcription, inhibited 15060166 2 0 0 formation of PML bodies +FLNA FLNA Actin-binding; Motility/polarity/chemotaxis; Nuclear receptor co-regulator P21333 2316 Xq28 human S1533-p 478649 GDEEVPRsPFKVKVL Filamin cell motility, induced; cytoskeletal reorganization 25445790 2 17 9 cell separation following mitosis, AAA mutant has defects in cell motility +PDCD4 PDCD4 Apoptosis; Tumor suppressor Q53EL6 27250 10q25.2 human R110-me 1873375608 RSRSGKGrGLPKKGG enzymatic activity, induced carcinogenesis, induced; cell growth, induced 21700716 1 0 0 Coexpression with PRMT5 with PDCD4-R110 and catalytic activity of both, are necessary for enhanced tumor growth. +FHIP2B FHIP2B Q86V87 64760 8p21.3 human S325-p 40642200 GISWRLPsAPSDEAS RAI16-like molecular association, regulation 14-3-3 theta(INDUCES) 25900241 1 0 0 +WASL N-WASP Adaptor/scaffold; Motility/polarity/chemotaxis Q95107 cow Y256-p 450253 RETSKVIyDFIEKTG PBD cytoskeletal reorganization 16199863 9 65 1373 required for formation of Shigella-induced actin comet tails +HMGA1 HMGA1 DNA-binding P17096 3159 6p21.31 human K71-ac 458953 SKNKGAAkTRKTTTT molecular association, regulation; acetylation transcription, induced NFkB-p105(INDUCES); ATF-2(INDUCES); NFkB-p65(INDUCES) 11498590; 9809067 4 2 0 optimum activation of transcription without effect on postinduction turnoff ; enhanceosome assembly, inhibits acetylation at K65 +MACF1 ACF7 Actin-binding; Cytoskeletal; Motility/polarity/chemotaxis Q9UPN3 23499 1p34.3 human S7330-p 468158 RASSRRGsDASDFDL intracellular localization cell motility, induced; cytoskeletal reorganization 21295697 1 24 5 inhibits localization along microtubules, alters organization of microtubules, regulates skin wound repair, SC migration +NFKB2 NFkB-p100 DNA-binding; Oncoprotein; Transcription factor Q00653 4791 10q24.32 human S711-p 25234803 PLPSPPTsDSDSDSE protein degradation; ubiquitination carcinogenesis, induced; cell growth, induced; apoptosis, inhibited; transcription, induced FBXW7(INDUCES) 22388891; 22864569 2 0 0 +CGAS cGAS EC 2.7.7.86 Q8N884 115004 6q13 human K394-sm 62952701 LNNHGKSkTCCENKE enzymatic activity, inhibited transcription, inhibited; signaling pathway regulation DNA(DISRUPTS) 28095500 1 0 0 regulation of STING signaling pathway +NFATC4 NFAT3 DNA-binding; Transcription factor Q14934 4776 14q12 human S285-p 13419501 SSASPALsRRGSLGE transcription, altered 17213202 1 1 0 +SLCO1B1 SLCO1B1 Membrane protein, integral; Membrane protein, multi-pass; Transporter; Transporter, SLC family Q9Y6L6 10599 12p12.1 human Y640-p 1872500200 RVSSLVLyIILIYAM activity, induced 33664059 1 1 0 +OCLN occludin Cell adhesion; Membrane protein, integral; Membrane protein, multi-pass; Motility/polarity/chemotaxis Q16625 100506658 5q13.2 human Y474-p 3666920 YREESEEyMAAADEY Occludin_ELL molecular association, regulation cell motility, altered PIK3R1(INDUCES) 20152177 1 0 2 +ERF ERF DNA-binding; Transcription factor P50548 2077 19q13.2 human T526-p 448321 GEAGGPLtPRRVSSD intracellular localization cell cycle regulation; transcription, induced 10330152; 14729966; 7588608 4 33 136 +Ksr2 KSR2 EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, Ser/Thr (non-receptor); Protein kinase, TKL Q3UVC0 333050 5|5 F mouse S475-p 4721669 ARLVRTEsVPCDINN molecular association, regulation; intracellular localization 14-3-3 beta(INDUCES) 19560418 1 7 3 +Cacna1e CACNA1E Channel, calcium; Membrane protein, integral; Membrane protein, multi-pass Q07652 54234 13q21 rat S369-p 455593 RRATIKRsRTEAMTR activity, induced 15840578 1 0 0 potentiation of Ca(2+) currents +CTNNB1 CTNNB1 Actin-binding; Cell adhesion; Motility/polarity/chemotaxis; Nuclear receptor co-regulator; Oncoprotein; Transcription factor P35222 1499 3p22.1 human S179-p 23096710 AVMVHQLsKKEASRH molecular association, regulation CEACAM1(INDUCES) 34656562 1 6 1 +KCNN4 KCNN4 Channel, potassium; Membrane protein, integral; Membrane protein, multi-pass O15554 3783 19q13.31 human T329-p 452144 AWMFYKHtRRKESHA CaMBD activity, inhibited 12029379 2 0 0 inhibition during prolonged PMA treatment (not short-term) +Foxo1 FOXO1A DNA-binding; Nuclear receptor co-regulator; Oncoprotein; Transcription factor Q9R1E0 56458 3 C|3 23.19 cM mouse S499-p 4911902 NVMMGPNsVMPAYGS FOXO_KIX_bdg transcription, inhibited 12724332 1 0 0 +Acaca ACC1 Carbohydrate Metabolism - propanoate; Carbohydrate Metabolism - pyruvate; EC 6.3.4.14; EC 6.4.1.2; Ligase; Lipid Metabolism - fatty acid biosynthesis P11497 60581 10q26 rat S1200-p 448290 IPTLNRMsFASNLNH ACC_central enzymatic activity, inhibited 7915280 3 4 2 +HSP90AB1 HSP90B Chaperone; Heat shock protein P08238 3326 6p21.1 human T89-p 18495101 RTLTLVDtGIGMTKA HATPase_c molecular association, regulation; intracellular localization cell growth, induced; transcription, induced AR(DISRUPTS) 30992362 2 2 1 +ESR1 ER-alpha DNA-binding; Nuclear receptor; Transcription factor P03372 2099 6q25.1-q25.2 human S282-p 6048401 EGRGEVGsAGDMRAA activity, inhibited transcription, altered 20043841 4 1 0 inhibits ligand-independent activation of ER-alpha +PARP1 PARP1 DNA repair, damage; EC 2.4.2.30; Nuclear envelope; Nuclear receptor co-regulator; Nucleolus; Transferase P09874 142 1q42.12 human Y907-p 53332701 MVSKSANyCHTSQGD PARP molecular association, regulation; enzymatic activity, induced DNA repair, induced; carcinogenesis, induced PARP2(DISRUPTS) 26779812; 33520371 3 0 0 +CAB2 CACNB2 Channel, calcium P54288 100009277 rabbit S322-p 2024725 ERSNTRSsLAEVQSE Guanylate_kin molecular association, regulation AHNAK(INDUCES) 22497893 1 1 0 +Atat1 ATAT1 iso2 ACETYLTRANSFERASE; Acetyltransferase; EC 2.3.1.108 Q8K341-2 73242 17|17 B1 mouse K221-ac 27581503 SSDREFLkVAVEPPW enzymatic activity, induced 23275437 1 1 0 +EIF4B EIF4B RNA-binding; Translation; Translation initiation P23588 1975 12q13.13 human S406-p 470374 RPRERHPsWRSEETQ molecular association, regulation cell cycle regulation; apoptosis, inhibited; translation, induced eIF3-alpha(INDUCES) 27528663 8 50 670 regulates protein synthesis during mitosis +SNCAIP SNCAIP Vesicle Q9Y6H5 9627 5q23.2 human S211-p 2873902 MAPFCVLsPVKSPHL molecular association, regulation PIN1(INDUCES) 16365047 1 0 0 +GNB1 G-beta 1 G protein; G protein, heterotrimeric; G protein, heterotrimeric beta P62873 2782 1p36.33 human K23-ub 7250962 NQIRDARkACADATL phosphorylation signaling pathway regulation 34342229 1 6 54 KCTD2/KCTD5-CUL3-RING E3 ligase promotes cAMP signaling in cancer-derived cell lines +POLH POLH DNA repair, damage; EC 2.7.7.7; Transferase Q9Y253 5429 6p21.1 human K224-sm 1877365904 SHNKVLAkLACGLNK IMS intracellular localization; enzymatic activity, inhibited 32350109 1 1 0 +Gja4 GJA4 Cell adhesion; Membrane protein, integral; Membrane protein, multi-pass P28235 14612 4 D2.2|4 61.47 cM mouse S325-p 1870939902 KSPSRPNsSASKKQY cell cycle regulation; apoptosis, induced 30736283 0 1 0 +PAK2 PAK2 EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, STE; Protein kinase, Ser/Thr (non-receptor) Q13177 5062 3q29 human T402-p 448300 PEQSKRStMVGTPYW Pkinase activity, induced; protein conformation; enzymatic activity, induced cell cycle regulation 20209159; 21098037; 25466889; 26078008 15 2 11 +Apex1 APE1 DNA repair, damage; DNA-binding; Deoxyribonuclease; EC 4.2.99.18; Endoplasmic reticulum; Hydrolase; Lyase; Nuclear receptor co-regulator; Nucleolus; Transcription, coactivator/corepressor P28352 11792 14 C1|14 26.3 cM mouse T232-p 14645304 NKKNAGFtPQERQGF Exo_endo_phos enzymatic activity, inhibited apoptosis, altered 20473298 2 0 0 in vitro and in MPP-treated neurons +GAP43 GAP43 Cell surface P06836 281777 cow S41-p 448719 AATKIQAsFRGHITR IQ protein processing 16212546; 17326767 14 9 5 inhibits cleavage by m-calpain; blocks proteolytic cleavage by m-calpain +Syne1 SYNE1 Actin-binding; Membrane protein, integral; RNA-binding Q6ZWR6 64009 10|10 A1 mouse S1389-p 30310302 EFSKRTEsIATQAEN receptor internalization, induced; molecular association, regulation; intracellular localization cytoskeletal reorganization ACTB(INDUCES) 24191017 1 1 0 localization to dendritic spines, GluA2 internalization +MAPK7 ERK5 EC 2.7.11.24; KINASE; Kinase, protein; Protein kinase, CMGC; Protein kinase, Ser/Thr (non-receptor) Q13164 5598 17p11.2 human S496-p 455518 SRLRDGPsAPLEAPE activity, inhibited; enzymatic activity, induced apoptosis, induced; transcription, inhibited 22267842; 30586719; 34619528 10 2 0 inhibits CHIP-Ubiquitin ligase activity; endothelial inflammation; induces PARP activity +Slc9a3 NHE3 Membrane protein, integral; Membrane protein, multi-pass; Transporter; Transporter, SLC family P26433 24784 1p11 rat S605-p 450900 SLEQRRRsIRDTEDM molecular association, regulation; intracellular localization; activity, inhibited SYT1(INDUCES) 11937500; 19926819; 21593184; 9933588 13 1 0 +KDELR1 KDELR1 Endoplasmic reticulum; Membrane protein, integral; Membrane protein, multi-pass P24390 10945 19q13.33 human S209-p 455669 VLKGKKLsLPA____ intracellular localization 14517323 1 0 0 +P2rx2 P2X2 Channel, cation; Channel, ligand-gated; Membrane protein, integral; Membrane protein, multi-pass P49653 114115 12q16 rat S363-p 1050143100 MNKNKLYsHKKFDKV P2X_receptor receptor desensitization, inhibited 29641486 1 0 0 constitutive phosphorylation blocks intracellular calcium-dependent facilitation of receptor desensitization +SAMHD1 SAMHD1 EC 3.1.4.- Q9Y3Z3 25939 20q11.23 human K622-ub 1878023500 KSRVQLFkDDPM___ protein degradation 31797533 1 1 0 +PTTG1 Securin Cell cycle regulation; Oncoprotein O95997 9232 5q33.3 human S31-p 30977068 LKLGSGPsIKALDGR Securin protein degradation; ubiquitination; enzymatic activity, induced chromatin organization, altered 24781523 1 6 0 1) Phosphorylation of securing leads to premature activation of separase. 2) Prevention of securin phosphorylation leads to impaired chromosome segregation and thereby leads to DNA damage. +OPTN optineurin Inhibitor Q96CV9 10133 10p13 human S177-p 4762451 SSGSSEDsFVEIRMA protein stabilization; molecular association, regulation; intracellular localization cell cycle regulation; autophagy, induced; apoptosis, induced SPTLC3(INDUCES); RAB8A(DISRUPTS) 21617041; 22365832; 26376340; 27035970; 27247382; 34099552 10 30 1 induces mitophagy; mitophagy, formation of autophagosomes around depolarized mitochondria +TFAM TFAM DNA-binding; Transcription regulation Q00059 7019 10q21.1 human K197-ac 1876567510 KNLSDSEkELYIQHA HMG_box_2 transcription, induced 35278431 0 1 0 +CD274 PD-L1 Membrane protein, integral Q9NZQ7 29126 9p24.1 human S283-p 14735979 DTNSKKQsDTHLEET protein degradation; molecular association, regulation; ubiquitination carcinogenesis, inhibited CMTM4(DISRUPTS); ARIH1(INDUCES) 33879767; 33909988 2 7 0 +Myc Myc DNA-binding; Nucleolus; Oncoprotein; Transcription factor P01108 17869 15 D1|15 26.19 cM mouse S344-p 2750300 AKRAKLDsGRVLKQI Myc_N protein stabilization transcription, induced; cell growth, altered 18438430 2 1 0 enhances the oncogenic transforming activity of c-Myc +SMAD2 SMAD2 DNA-binding; Transcription factor Q15796 4087 18q21.1 human S260-p 450146 TLSPVNHsLDLQPVT molecular association, regulation; intracellular localization SMAD3(INDUCES) 11027280 1 0 0 +SLC9A1 NHE1 Membrane protein, integral; Membrane protein, multi-pass; Motility/polarity/chemotaxis; Transporter; Transporter, SLC family P19634 6548 1p36.11 human S796-p 460570 QRIQRCLsDPGPHPE molecular association, regulation CA2(NOT_REPORTED) 16475831 3 29 41 +EEF2K EEF2K EC 2.7.11.20; KINASE; Kinase, protein; Protein kinase, Ser/Thr (non-receptor); Protein kinase, atypical; Translation O00418 29904 16p12.2 human S72-p 3150896 KSERYSSsGSPANSF enzymatic activity, inhibited carcinogenesis, induced; cell growth, induced; translation, induced 35513296 0 12 1 +AURKA AurA EC 2.7.11.1; KINASE; Kinase, protein; Oncoprotein; Protein kinase, Other; Protein kinase, Ser/Thr (non-receptor) O14965 6790 20q13.2 human Y148-p 457653 KGKFGNVyLAREKQS Pkinase intracellular localization cell cycle regulation 27242098 2 5 7 centrosomal recruitment +APEX1 APE1 DNA repair, damage; DNA-binding; Deoxyribonuclease; EC 4.2.99.18; Endoplasmic reticulum; Hydrolase; Lyase; Nuclear receptor co-regulator; Nucleolus; Transcription, coactivator/corepressor P27695 328 14q11.2 human K27-ub 6423507 EPEAKKSkTAAKKND protein degradation; enzymatic activity, altered 19219073 1 0 0 +PDPK1 PDK1 EC 2.7.11.1; KINASE; Kinase, protein; Nuclear receptor co-regulator; Protein kinase, AGC; Protein kinase, Ser/Thr (non-receptor) O15530 5170 16p13.3 human S241-p 447693 SKQARANsFVGTAQY Pkinase molecular association, regulation; phosphorylation; enzymatic activity, induced carcinogenesis, induced; cell growth, induced; apoptosis, inhibited; autophagy, inhibited; signaling pathway regulation 14-3-3 theta(INDUCES); 14-3-3 eta(INDUCES) 10455013; 12177059; 14623982; 16780920; 21118801; 21308747; 22080480; 25384981; 27002159; 33755959; 35564180; 35884549; 36418288 63 95 264 induces Akt/mTOR signalling +PDGFRB PDGFRB EC 2.7.10.1; KINASE; Kinase, protein; Membrane protein, integral; Oncoprotein; Protein kinase, TK; Protein kinase, tyrosine (receptor) P09619 5159 5q32 human Y1021-p 447523 PNEGDNDyIIPLPDP activity, induced; molecular association, regulation; phosphorylation PLCG1(INDUCES) 11884598; 1396585; 7678051; 7876130; 9673410 21 0 0 Y1009 and Y1021 phosphorylation mediates PDGFBB and thrombin induced calcium signaling. ; Specificity of binding of SH2 domains can be tailored by change of residues in the +1 to +5 positions, flanking the phosphotyrosine. +PLD2 PLD2 EC 3.1.4.4; Lipid Metabolism - ether lipid; Lipid Metabolism - glycerophospholipid; Motility/polarity/chemotaxis; Phospholipase O14939 5338 17p13.2 human Y415-p 10036101 ALGINSGySKRALML molecular association, regulation; enzymatic activity, induced carcinogenesis, induced; cell motility, induced JAK2(INDUCES) 19715678; 20176813; 21414324; 23378025; 26124282 5 1 0 activates lipase activity and inhibits GEF activity +ESR1 ER-alpha DNA-binding; Nuclear receptor; Transcription factor P03372 2099 6q25.1-q25.2 human S102-p 449799 GGFPPLNsVSPSPLM Oest_recep activity, induced transcription, induced 16076840 3 1 0 +POLH POLH DNA repair, damage; EC 2.7.7.7; Transferase Q9Y253 5429 6p21.1 human K70-sm 1877365916 MWADDAKkLCPDLLL IMS intracellular localization; enzymatic activity, inhibited 32350109 1 1 0 +CD1D CD1D Apoptosis; Cell surface; Lipid-binding; Membrane protein, integral P15813 912 1q23.1 human S323-p 23091771 LLIVGFTsRFKRQTS protein degradation; intracellular localization 23710894 1 0 1 inhibits cell surface expression and antigen presentation +Npm1 NPM1 Nucleolus; Oncoprotein; RNA-binding; Translation Q61937 18148 11|11 A4 mouse K54-ac 15291352 VSLGAGAkDELHIVE Nucleoplasmin molecular association, regulation; intracellular localization MDM2(DISRUPTS) 33495326 1 5 1 Deacetylation of NPM1 at K27 and K54 leads to release of NPM from nucleoli and its association with HDM2. As a result HDM2-mediated proteasomal degradation of p53 is inhibited +SYK Syk EC 2.7.10.2; KINASE; Kinase, protein; Protein kinase, TK; Protein kinase, tyrosine (non-receptor) P43405 6850 9q22.2 human Y630-p 459326 ELRLRNYyYDVVN__ enzymatic activity, altered transcription, altered 9624129 3 2 5 +Plk4 PLK4 EC 2.7.11.21; KINASE; Kinase, protein; Nucleolus; Protein kinase, Other; Protein kinase, Ser/Thr (non-receptor) Q64702 20873 3|3 B mouse S303-p 12654008 ASSGTSLsGSLLDRR protein degradation; ubiquitination 20100909 2 1 0 +SF3B2 SF3B2 RNA processing; RNA splicing; RNA-binding; Spliceosome Q13435 10992 11q13.1 human S289-p 477883 SRQEEMNsQQEEEEM DNA repair, induced 29705135 1 18 0 accumulate CtIP at sites of DNA breaks +Agtr1 AT1 GPCR, family 1; Membrane protein, integral; Membrane protein, multi-pass; Receptor, GPCR P25095 24180 17p12 rat T336-p 467237 SLSTKMStLSYRPSD molecular association, regulation ARRB2(INDUCES) 29146594 3 0 0 BRET +AR AR DNA-binding; Nuclear receptor; Transcription factor P10275 367 Xq12 human S220-p 1875072200 EASGAPTsSKDNYLG Androgen_recep molecular association, regulation transcription, induced 14-3-3 zeta(INDUCES) DNA(INDUCES) 34697370 1 0 0 +RPRD1B RPRD1B Motility/polarity/chemotaxis Q9NQG5 58490 20q11.23 human S145-p 10404515 KATEEKKsLKRTFQQ molecular association, regulation cell cycle regulation; carcinogenesis, induced; cell growth, induced; transcription, induced; cytoskeletal reorganization AurB(INDUCES) 30518842 1 1 2 regulate the expression of cyclin B1 in gastric cancer +Tnni3 TNNI3 Actin-binding; Motility/polarity/chemotaxis; Motor P48787 21954 7 A1|7 2.61 cM mouse S45-p 450691 KKSKISAsRKLQLKT activity, induced; activity, inhibited; protein conformation cell motility, altered; cytoskeletal reorganization 12003851; 12181153; 12923217; 14726296; 17010989; 17872964; 19426736; 20083117 22 3 0 slows rate of contraction and relaxation +MET Met EC 2.7.10.1; KINASE; Kinase, protein; Membrane protein, integral; Oncoprotein; Protein kinase, TK; Protein kinase, tyrosine (receptor) P08581 4233 7q31.2 human Y1356-p 448473 YVHVNATyVNVKCVA activity, induced; molecular association, regulation; enzymatic activity, induced carcinogenesis, induced; cell motility, induced; cell growth, induced; cell motility, altered; signaling pathway regulation; cell growth, altered PIK3C2A(INDUCES); GRB2(INDUCES); Src(INDUCES); PLCG1(INDUCES); Ron(INDUCES); SOS1(INDUCES); GAB1(INDUCES); Met(INDUCES); SHC1(INDUCES); FAK(INDUCES); PIK3R1(INDUCES) 10490849; 10506185; 10871856; 12766170; 16782899; 21777671; 7513258; 7687741; 7731718; 7838524; 7961992; 8547236; 8906793; 9242692; 9391119; 9444958 23 4 122 binding of Gab1 is dependent on Grb2; Double mutant Y1349F/Y1356F inhibits both metastasis and transformation. N1358H is also critical for malignant transformation as it affects Grb2 binding and activation of the Ras pathway (mutantGRB-). H1352N which makes an high affinity GRB2 was highly transforming, but not metastatic (mutant 2X Grb2). Expression of the recombinant oncogene TPR-SEA, was comaparable to 2X GRB2 mutant phenotype. A GRB2/2X GRB2 mutant was rescued by complementation in trans and resumed the ability to invade an in vitro reconstituted basement membrane. ; promotes cell transformation in Tpr-Met expressing cells +NDEL1 NDEL1 Microtubule-binding; Protease Q9GZM8 81565 17p13.1 human S231-p 474507 GTENTFPsPKAIPNG NUDE_C molecular association, regulation; intracellular localization PAFAH1B1(INDUCES); DYNC1I1(INDUCES) 12556484; 37086789 5 18 0 +Eif4ebp1 4E-BP1 Translation; Translation initiation Q60876 13685 8 A2|8 15.95 cM mouse T36-p 447497 PPGDYSTtPGGTLFS eIF_4EBP molecular association, regulation carcinogenesis, induced; apoptosis, inhibited; transcription, induced; translation, induced; signaling pathway regulation EIF4E(DISRUPTS); EIF4E(INDUCES) 11875068; 17510058; 18851840; 33567340; 34704268; 36012713; 37264081 159 44 88 +Arrb1 ARRB1 Adaptor/scaffold P29066 25387 1q32 rat S412-p 447493 EEDDGTGsPHLNNR_ intracellular localization 9388255 8 46 1 Cytoplasmic beta-arrestin 1 is constitutively phosphorylated. It is recruited to the plasma membrane by agonist binding to receptor where is rapidly dephosphorylated. Dephosphorylation is required for clathrin binding and receptor endocytosis. +HSPA5 GRP78 Chaperone; Heat shock protein; KINASE P11021 3309 9q33.3 human K138-ac 13362606 DIGGGQTkTFAPEEI HSP70 molecular association, regulation; phosphorylation apoptosis, induced; signaling pathway regulation PERK(DISRUPTS) 20371724 1 1 0 induces phosphorylation of elf2a and activation of eIf2a-ATF4-CHOP pathway +Myo1c MYO1C iso3 Actin-binding; Contractile; Lipid-binding; Motility/polarity/chemotaxis; Motor; Nucleolus Q9WTI7-3 17913 11 B5|11 45.92 cM mouse S1020-p 34404301 DGIIDFTsGSELLIT Myosin_TH1 protein stabilization; molecular association, regulation cell cycle regulation; transcription, induced DNA(INDUCES) 24901984 1 1 0 +HSPD1 HSP60 Chaperone; Mitochondrial P10809 3329 2q33.1 human S70-p 468008 IIEQSWGsPKVTKDG Cpn60_TCP1 protein conformation 34557266 1 66 0 regulates folding of ALDH2 and ACADS +ITK ITK EC 2.7.10.2; KINASE; Kinase, protein; Protein kinase, TK; Protein kinase, tyrosine (non-receptor) Q08881 3702 5q33.3 human Y180-p 449834 ETVVIALyDYQTNDP SH3_1 phosphorylation; enzymatic activity, induced signaling pathway regulation 31196981 3 0 80 autophosphorylation at Y180 +Psma1 PSMA1 EC 3.4.25.1; Protease; Proteasome complex Q9R1P4 26440 7 F1|7 59.32 cM mouse K115-ac 31910304 LVSLIGSkTQIPTQR Proteasome protein degradation 24037710 0 1 0 +OGG1 OGG1 DNA repair, damage; Deoxyribonuclease; EC 4.2.99.18; Lyase O15527 4968 3p25.3 human K338-ac 40320204 EPPAKRRkGSKGPEG DNA repair, induced; apoptosis, inhibited 25660075 1 0 0 +BCL10 Bcl-10 Apoptosis; Transcription, coactivator/corepressor; Tumor suppressor O95999 8915 1p22.3 human K17-ub 59171801 EEDLTEVkKDALENL molecular association, regulation carcinogenesis, induced; transcription, induced; signaling pathway regulation IKKG(INDUCES) 27777308 1 0 0 TCR-mediated NF-?B activation +Crtc2 TORC2 Transcription, coactivator/corepressor Q3U182 74343 3|3 F1 mouse S136-p 454632 PYSPAYLsPPPESGW molecular association, regulation; intracellular localization transcription, induced SEC31A(DISRUPTS) 33434948 3 16 43 binding to SEC31A inhibits SEC31A binding to SEC23A +Cyp2e1 CYP2E1 EC 1.14.13.n7; Endoplasmic reticulum; Lipid Metabolism - arachidonic acid; Lipid Metabolism - linoleic acid; Mitochondrial; Oxidoreductase; Xenobiotic Metabolism - drug metabolism - cytochrome P450; Xenobiotic Metabolism - metabolism by cytochrome P450 Q05421 13106 7 F4|7 85.94 cM mouse R379-me 1878196104 ATRDTVFrGYVIPKG protein degradation 31077594 1 1 0 me-CYP2E1 is reduced in Mat1a KO liver mitochondria; down-regulation of CYP2E1 protein level requires R379 methylation +YWHAB 14-3-3 beta iso2 Adaptor/scaffold P31946-2 7529 20q13.12 human K49-ac 474927 NLLSVAYkNVVGARR 14-3-3 intracellular localization; activity, inhibited cell differentiation, induced 34379822 2 5 15 osteogenesis +MAPRE1 EB1 Cytoskeletal; Motility/polarity/chemotaxis Q15691 22919 20q11.21 human Y247-p 59026901 QRIVDILyATDEGFV EB1 molecular association, regulation; intracellular localization; protein conformation; phosphorylation cell cycle regulation; cell motility, induced; transcription, induced; cytoskeletal reorganization; cell adhesion, altered; signaling pathway regulation KIF2C(DISRUPTS); APC(DISRUPTS) 27698945; 31505167; 32469452 3 1 0 Regulates astral microtubule stability and spindle misorientation; regulates TCR signaling; increases levels of CD25 and CD69; phosphorylation of EB1 at Y247 occurs primarily at the centrosome, increases the rate of microtuble catastrophe; induces phosphorylation of ZAP-70, LAT and ERK; increase NFAT1 nuclear translocation +IRF3 IRF3 DNA-binding; Transcription factor Q14653 3661 19q13.33 human K87-sm 25174503 FRSALNRkEGLRLAE IRF protein stabilization; ubiquitination 22028379 1 0 0 deSUMOylation promotes ubiquitination and degradation at the same residues +DDX5 DDX5 EC 3.6.4.13; Helicase; Nuclear receptor co-regulator; Nucleolus; RNA splicing; RNA-binding; Spliceosome P17844 1655 17q23.3 human K45-ac 15211500 GEKLVKKkWNLDELP protein stabilization; molecular association, regulation carcinogenesis, induced; transcription, induced HDAC1(INDUCES); HDAC2(INDUCES) 20663877 1 1 0 +Shtn1 SHOT1 Unknown function Q8K2Q9 71653 19|19 D2-D3 mouse S249-p 485709 QNKLKRQsHLLLQSS molecular association, regulation neural plasticity; cell adhesion, induced; cytoskeletal reorganization CDH2(INDUCES); Cortactin(INDUCES); NCAM-L1(INDUCES) 34010643 4 19 4 +Sod2 SOD2 EC 1.15.1.1; Mitochondrial; Oxidoreductase P09671 20656 17 A1|17 8.75 cM mouse R197-m2 1872904404 YLQYKNVrPDYLKAI Sod_Fe_C cell cycle regulation 22710435 1 1 0 quiescent fibroblasts are dimethylated at K122, and R197 and are also dimethylated in proliferating cells +Ccnd1 CCND1 Activator; Cell cycle regulation; Nuclear receptor co-regulator; Oncoprotein P25322 12443 7 F5|7 88.92 cM mouse T288-p 451435 AGLACTPtDVRDVDI protein degradation cell cycle regulation 15075324; 19542220 5 0 0 +Pdha1 PDHA1 Amino Acid Metabolism - valine, leucine and isoleucine biosynthesis; Carbohydrate Metabolism - butanoate; Carbohydrate Metabolism - citrate (TCA) cycle; Carbohydrate Metabolism - glycolysis and gluconeogenesis; Carbohydrate Metabolism - pyruvate; EC 1.2.4.1; Mitochondrial; Oxidoreductase P35486 18597 X F4|X 73.95 cM mouse K385-ac 1204112 RGANQWIkFKSVS__ enzymatic activity, inhibited 34518519 1 3 1 metabolic reprogramming associated with renal ?brosis +Vrk1 VRK1 EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, CK1; Protein kinase, Ser/Thr (non-receptor) Q80X41 22367 12|12 E-F1 mouse S355-p 483969 SVKTRPAsKKRKKEA enzymatic activity, inhibited cell cycle regulation; apoptosis, altered 21346188 3 0 0 +Wnk1 WNK1 EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, Other; Protein kinase, Ser/Thr (non-receptor) Q9JIH7 116477 4q42 rat S382-p 454105 KRASFAKsVIGTPEF Pkinase enzymatic activity, induced 12374799 9 10 3 +PPP1R2 PPP1R2 Inhibitor; Motility/polarity/chemotaxis; Protein phosphatase, regulatory subunit P41236 5504 3q29 human S121-p 449052 YRIQEQEsSGEEDSD IPP-2 intracellular localization 9405437 3 72 29 Phosphorylation is required for nuclear localization during S phase. +TET2 TET2 EC 1.14.11.n2; Oxidoreductase; Tumor suppressor Q6N021 54790 4q24 human Y1902-p 1870773107 TRISLVFyQHKSMNE Tet_JBP protein degradation; ubiquitination cell cycle regulation; carcinogenesis, induced; cell growth, induced; apoptosis, inhibited; transcription, inhibited 33097695 1 1 0 +Themis THEMIS Cell development/differentiation Q8BGW0 210757 10|10 A4 mouse Y543-p 27806310 EITEEQYyMMRRYES cell differentiation, induced 23460737 1 1 0 thymocyte development +Sh2d1b SH2D1B Adaptor/scaffold O35324 26904 1|1 H3 mouse Y127-p 4140135 YENTDEEyVDVLP__ molecular association, regulation exocytosis, induced; cytoskeletal reorganization PLCG1(INDUCES) 24687958 2 0 8 activating function of CD244 required the C-terminal tyrosine Y127, SH2D18 promoted MTOC and granule polarization and exocytosis +IL7R IL7R Membrane protein, integral; Receptor, cytokine P16871 3575 5p13.2 human Y449-p 451291 GSNQEEAyVTMSSFY molecular association, regulation PIK3R1(INDUCES) 7522165 7 0 0 +TARBP2 TRBP Motility/polarity/chemotaxis; RNA processing; RNA-binding; Translation Q15633 6895 12q13.13 human K52-sm 52477001 TPVYDLLkAEGQAHQ dsrm protein stabilization; molecular association, regulation; ubiquitination carcinogenesis, inhibited; cell motility, inhibited; RNA stability, inhibited AGO2(INDUCES) RNA(INDUCES) 26582366 1 0 0 inhibits ubiquitination +KIF2A KIF2A Microtubule-binding; Motor O00139 3796 5q12.1 human S100-p 23119257 KNRRTVAsIKNDPPS activity, induced; molecular association, regulation; intracellular localization cell cycle regulation DVL1(INDUCES); DVL3(INDUCES); DVL2(INDUCES) 34417301 1 10 2 +H1-2 H1C DNA-binding P16403 3006 6p22.2 human T146-p 9765189 KKAAGGAtPKKSAKK molecular association, regulation cell cycle regulation; carcinogenesis, inhibited; cell growth, inhibited; apoptosis, induced; cell motility, inhibited; transcription, induced; transcription, altered p53(DISRUPTS) 22249259; 24601643; 28392790; 31032946 4 17 8 +Camk2a CAMK2A EC 2.7.11.17; KINASE; Kinase, protein; Protein kinase, CAMK; Protein kinase, Ser/Thr (non-receptor) P11275 25400 18q12.1 rat T305-p 448802 KLKGAILtTMLATRN molecular association, regulation; enzymatic activity, inhibited cytoskeletal reorganization Calmodulin(DISRUPTS) 1324926; 20660727; 2162839 24 5 1 regulate synaptic strength +WT1 WT1 iso7 C2H2-type zinc finger protein; DNA-binding; Nucleolus; Transcription factor; Tumor suppressor P19544-7 7490 11p13 human S67-p 56653434 GRRSRGAsGSEPQQM protein stabilization carcinogenesis, induced; cell growth, induced 29040381 2 3 0 +HNRNPD hnRNP D0 RNA splicing; RNA-binding Q14103 3184 4q21.22 human S83-p 449336 DEGHSNSsPRHSEAA phosphorylation transcription, inhibited; RNA stability, altered RNA(INDUCES) 11903055; 12819194; 36041631 4 74 16 +Ripk3 RIPK3 EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, Ser/Thr (non-receptor); Protein kinase, TKL Q9QZL0 56532 14|14 C3 mouse S369-p 27928505 ERQAQDTsVGPATPA protein stabilization; molecular association, regulation apoptosis, induced FADD(INDUCES) 33870135 2 2 0 prevents ripoptosome-mediated cleavage of RIPK3 +Snai1 Snail1 C2H2-type zinc finger protein; Transcription factor Q02085 20613 2 H3|2 87.33 cM mouse S165-p 1876128600 YCNKEYLsLGALKMH zf-C2H2_6 protein stabilization; molecular association, regulation; ubiquitination carcinogenesis, induced; cell motility, induced; transcription, altered BTRC(DISRUPTS) 35066576 1 1 0 inhibits ubiquitination +MARCKS MARCKS Actin-binding; Motility/polarity/chemotaxis P29966 4082 6q21 human S167-p 466360 FKKSFKLsGFSFKKN MARCKS exocytosis, inhibited 21762971 7 44 11 induce MUC5AC secretion by cold +ESR2 ER-beta DNA-binding; Nuclear receptor Q92731 2100 14q23.2-q23.3 human Y488-p 450057 CKNVVPVyDLLLEML activity, induced; molecular association, regulation; protein conformation SRC-2(INDUCES); PGC-1 alpha(INDUCES); NR0B1(INDUCES); RIP140(INDUCES); SRC-1(INDUCES) 25386784 3 1 0 based on in-vitro binding affinities of phosphorylated ER-beta to corresponding coregulator peptides +Stk4 MST1 Autophagy; EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, STE; Protein kinase, Ser/Thr (non-receptor) Q9JI11 58231 2|2 H3 mouse S327-p 447924 SEEDEMDsGTMVRAA enzymatic activity, induced cell adhesion, altered 12223493 2 1 1 +ARAF ARAF EC 2.7.11.1; KINASE; Kinase, protein; Oncoprotein; Protein kinase, Ser/Thr (non-receptor); Protein kinase, TKL P10398 369 Xp11.3 human S432-p 3306310 IIHRDLKsNNIFLHE PK_Tyr_Ser-Thr enzymatic activity, induced 18662992 1 1 0 +CDH1 CDH1 Cell adhesion; Membrane protein, integral; Motility/polarity/chemotaxis; UBIQUITIN LIGASE; Ubiquitin ligase P12830 999 16q22.1 human S844-p 478354 GSGSEAAsLSSLNSS CADH_Y-type_LIR protein stabilization; molecular association, regulation; intracellular localization carcinogenesis, altered; cell motility, inhibited; cell adhesion, altered CTNNB1(DISRUPTS) 17353278; 35115926 4 0 0 +Tcap Telethonin Motility/polarity/chemotaxis O70548 21393 11|11 D mouse S161-p 3893741 RTLSRSMsQEAQRG_ Telethonin protein stabilization; ubiquitination 34566695 3 8 3 inhibits ubiquitination +KDM3A JMJD1A DEMETHYLASE; Demethylase; EC 1.14.11.-; Nuclear receptor co-regulator; Oxidoreductase Q9Y4C1 55818 2p11.2 human K421-ac 1877323800 PKECLPTkASSKAEL protein stabilization; intracellular localization carcinogenesis, induced; cell growth, induced CHIP(DISRUPTS); BRD4(INDUCES) 32522824 1 1 0 K421 acetylation promotes JMJD1A recruitment to AR via BRD4 and prostate cancer cell growth +CDKN1B p27Kip1 Cell cycle regulation; Inhibitor; Oncoprotein; Protein kinase, regulatory subunit P46527 1027 12p13.1 human S140-p 481797 PKTDPSDsQTGLAEQ protein stabilization cell cycle regulation; cell growth, inhibited 27611996; 31959038 3 4 1 +Cish CISH O70512 83681 8q32 rat K58-ub 37044804 VQSENEPkVLDPEGD protein degradation 25448846 1 0 0 +Khdc3 KHDC3L Cell cycle regulation Q9CWU5 66991 9|9 D mouse S349-p 41159605 REAATQLsPVEATDT intracellular localization DNA repair, induced 25936915 1 0 0 required for KHD3CL function in DNA repair and nuclear localization +DDAH2 DDAH2 Apoptosis; EC 3.5.3.18; Hydrolase O95865 23564 6p21.33 human T203-p 1872776102 VRAMAVLtDHPYASL intracellular localization; phosphorylation; enzymatic activity, induced signaling pathway regulation 33850055 1 1 0 regulates RLR signaling, regulates DRP1 anf IRF3 phosphorylation +KDM4B JMJD2B DEMETHYLASE; Demethylase; EC 1.14.11.-; Oxidoreductase O94953 23030 19p13.3 human T1065-p 479896 AKRPRVGtPLATEDS protein stabilization; ubiquitination 28945223 1 11 92 +IL24 IL24 Motility/polarity/chemotaxis; Secreted; Secreted, signal peptide Q13007 11009 1q32.1 human T133-p 41122602 NRTVEVRtLKSFSTL activity, induced; intracellular localization cell cycle regulation; carcinogenesis, inhibited; cell growth, inhibited; cell motility, inhibited; signaling pathway regulation 26009991 1 0 0 IL24 maturation and secretion; activates Caspase-9, PARP, and JNK; inhibits the AKT signaling pathway +PIK3C3 PIK3C3 Autophagy; Carbohydrate Metabolism - inositol phosphate; EC 2.7.1.137; Kinase, lipid; Motility/polarity/chemotaxis Q8NEB9 5289 18q12.3 human K781-ac 280006401 PPPMKLNkEMVEGMG PI3_PI4_kinase enzymatic activity, inhibited autophagy, inhibited 28844862 1 1 0 nutrient starvation-induced autophagy +LRRK1 LRRK1 EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, Ser/Thr (non-receptor); Protein kinase, TKL Q38SD2 79705 15q26.3 human S1074-p 1879806802 GNQRNRCsTFRVKRN phosphorylation; enzymatic activity, induced 36040231 1 1 0 induces Rab7 phosphorylation +Nr1h3 LXR-alpha DNA-binding; Motility/polarity/chemotaxis; Nuclear receptor Q9Z0Y9 22259 2 E1|2 50.52 cM mouse S195-p 479432 TSVSPRVsSPPQVLP molecular association, regulation; activity, inhibited cell growth, induced; apoptosis, induced; transcription, altered; transcription, inhibited; signaling pathway regulation SRC-1(DISRUPTS); N-CoR1(INDUCES); RXRA(DISRUPTS) 17296605; 33772096 2 0 0 regulates inflammatory signaling; DNA Binding Activity of LXR/ RXR heterodimer was decreased. +PCNA PCNA Cell cycle regulation; DNA replication P12004 5111 20p12.3 human Y211-p 471414 QLTFALRyLNFFTKA PCNA_C molecular association, regulation; protein stabilization; ubiquitination carcinogenesis, induced; cell growth, induced; DNA repair, inhibited CUL4A(DISRUPTS) 17115032; 22692198; 25825764; 28102297 7 2 2 +ID1 ID1 DNA-binding; Transcription, coactivator/corepressor P41134 3397 20q11.21 human S36-p 15411040 GEVVRCLsEQSVAIS molecular association, regulation; ubiquitination TRAF6(INDUCES) 29079782 1 2 4 +PDE4D PDE4D iso6 EC 3.1.4.53; Nucleotide Metabolism - purine; Phosphodiesterase Q08499-6 5144 5q11.2-q12.1 human K140-ub 7388020 SDYDLSPkSMSRNSS molecular association, regulation; ubiquitination RACK1(DISRUPTS); ARRB1(INDUCES) 19372219 1 0 0 primes ubiquitination at other sites +EHMT2 EHMT2 Amino Acid Metabolism - lysine degradation; EC 2.1.1.43; METHYLTRANSFERASE; Methyltransferase; Methyltransferase, protein lysine Q96KQ7 10919 6p21.33 human S569-p 456315 APAPPPLsQDVPGRA intracellular localization DNA repair, induced 29192276 1 7 22 recruitment to DNA breaks +PACSIN2 PACSIN2 Adaptor/scaffold; Motility/polarity/chemotaxis Q9UNF0 11252 22q13.2 human S375-p 4786399 DDTGSTVsEKDDTKA molecular association, regulation; receptor internalization, altered neural plasticity PICK1(DISRUPTS) 23918399 1 9 0 regulates AMPAR trafficking +COP1 COP1 EC 6.3.2.-; EC 6.3.2.19; Ligase; UBIQUITIN LIGASE; Ubiquitin conjugating system; Ubiquitin ligase Q8NHY2 64326 1q25.1-q25.2 human S387-p 467307 SDDSRTAsQLDEFQE protein degradation; molecular association, regulation; ubiquitination; intracellular localization 14-3-3 sigma(INDUCES); p27Kip1(DISRUPTS); p53(DISRUPTS) 16931761; 20843328; 25957415 3 0 1 +Becn1 beclin 1 Adaptor/scaffold; Autophagy; Membrane protein, peripheral Q91XJ1 rat T117-p 6406000 LSRRLKVtGDLFDIM BH3 autophagy, induced 35263212 4 0 0 +FSCN1 fascin Actin-binding; Cytoskeletal; Motility/polarity/chemotaxis Q16658 6624 7p22.1 human S39-p 450888 KVNASASsLKKKQIW Fascin molecular association, regulation; intracellular localization; protein conformation cell growth, inhibited; cell motility, inhibited; cytoskeletal reorganization FMNL2(DISRUPTS); ACTA1(DISRUPTS); ACTA1(INDUCES) 20137952; 27554857; 28251354; 30664308; 32294157; 8999969 13 12 0 +ARAF ARAF EC 2.7.11.1; KINASE; Kinase, protein; Oncoprotein; Protein kinase, Ser/Thr (non-receptor); Protein kinase, TKL P10398 369 Xp11.3 human S264-p 3306300 SPSPASVsSGRKSPH enzymatic activity, induced 18662992 1 1 0 +INSIG2 INSIG2 Endoplasmic reticulum; Membrane protein, integral; Membrane protein, multi-pass; Transcription, coactivator/corepressor Q9Y5U4 51141 2q14.1-q14.2 human K102-ub 486342 LGEPHKFkREWSSVM INSIG protein degradation 16549805 1 0 0 INSIG1 is degraded more rapidly than INSIG2 which controlled by serine residues flanking the ubiquitination sites in both proteins. +PARP1 PARP1 DNA repair, damage; EC 2.4.2.30; Nuclear envelope; Nuclear receptor co-regulator; Nucleolus; Transferase P09874 142 1q42.12 human S177-p 18013484 LGFRPEYsASQLKGF zf-PARP molecular association, regulation cell adhesion, induced; transcription, altered; signaling pathway regulation DNA(DISRUPTS) 23382195 2 4 0 induces transcription of itself and inhibits transcription of VCAM-1, MCP-1, and MCP-3, regulates AMPK-PARP-1-Bcl-6 pathway +CDC25A CDC25A EC 3.1.3.48; Motility/polarity/chemotaxis; PHOSPHATASE; Protein phosphatase, dual-specificity P30304 993 3p21.31 human S124-p 449127 PALKRSHsDSLDHDI M-inducer_phosp protein degradation 11298456; 12676583 7 1 0 +PROM1 CD133 iso2 Cell surface; Membrane protein, integral; Membrane protein, multi-pass O43490-2 8842 4p15.32 human Y819-p 462569 RMDSEDVyDDVETIP molecular association, regulation ARL13B(INDUCES) 32201384 4 2 20 regulates ciliary length +TACSTD2 TACSTD2 Membrane protein, integral; Receptor, misc. P09758 4070 1p32.1 human S322-p 470219 GELRKEPsL______ protein degradation; molecular association, regulation; intracellular localization; phosphorylation carcinogenesis, induced; cell growth, induced; cell motility, induced; cytoskeletal reorganization; transcription, altered; signaling pathway regulation Claudin-7(DISRUPTS) 31177095; 35132180; 37380081 3 8 0 induces STAT3 phosphorylation, regulates ?-catenin signaling +Ppargc1b PGC-1 beta Nuclear receptor co-regulator; Transcription, coactivator/corepressor Q8VHJ7 170826 18|18 E1 mouse K218-ac 7761208 RPCTELHkHLTSVLP intracellular localization transcription, inhibited 19491097 1 1 0 +Cd83 CD83 Membrane protein, integral O88324 12522 13 A4|13 21.6 cM mouse K183-ub 9381802 LPVTSPSkHLGPVTL protein degradation 19542455 1 3 0 +POLB POLB DNA repair, damage; DNA replication; EC 2.7.7.7; Lyase; Transferase P06746 5423 8p11.21 human S44-p 41521700 NAYRKAAsVIAKYPH HHH_8 enzymatic activity, inhibited; protein conformation 29223917; 30138833; 37240334 4 1 0 +KDM1A LSD1 DEMETHYLASE; Demethylase; EC 1.-.-.-; Nuclear receptor co-regulator; Oxidoreductase; Transcription factor O60341 23028 1p36.12 human S683-p 57786402 NLFGHVGsTTASRGE Amino_oxidase protein stabilization; molecular association, regulation; intracellular localization; phosphorylation cell growth, induced USP22(INDUCES) 27501329 1 0 0 S687 phosphorylation by CK1 primes for GSK3B phosphorylation S683 deubiquitylation, maintaining the stemness of GSCs +TK1 TK EC 2.7.1.21; KINASE; Kinase, other; Nucleotide Metabolism - pyrimidine; Xenobiotic Metabolism - drug metabolism - other enzymes P04183 7083 17q25.3 human S231-p 483564 PQQILQCsPAN____ enzymatic activity, induced 25003822 1 21 5 TK phosphorylation-modulated [18F]FLT cellular retention +JUN Jun Oncoprotein; Transcription factor P05412 3725 1p32.1 human Y170-p 447687 LHSEPPVyANLSNFN Jun molecular association, regulation Abl iso2(INDUCES) 10637231 2 1 0 +AKT1 Akt1 EC 2.7.11.1; KINASE; Kinase, protein; Oncoprotein; Protein kinase, AGC; Protein kinase, Ser/Thr (non-receptor) P31749 207 14q32.33 human R391-m2 1883833702 LKKDPKQrLGGGSED intracellular localization; enzymatic activity, induced carcinogenesis, induced; cell growth, induced 34103528 1 1 0 AKT1 membrane translocation and subsequent activation by PDK1 and mTORC2; PI3K signaling enhances AKT1-R391 dimethylation +STAT1 STAT1 DNA-binding; Transcription factor P42224 6772 2q32.2 human S708-p 7723201 YIKTELIsVSEVHPS transcription, induced 24882218 2 2 0 +MC4R MC4R GPCR, family 1; Membrane protein, integral; Membrane protein, multi-pass; Receptor, GPCR P32245 4160 18q21.32 human S329-p 449102 LGGLCDLsSRY____ receptor recycling, inhibited; intracellular localization; receptor internalization, altered; activity, inhibited 12639913; 22544740 2 0 0 retains MC4R in the endosomal compartment +Ptpra PTPRA EC 3.1.3.48; Membrane protein, integral; Motility/polarity/chemotaxis; PHOSPHATASE; Receptor protein phosphatase, tyrosine P18052 19262 2 F1|2 63.23 cM mouse S204-p 447612 PLLARSPsTNRKYPP molecular association, regulation; enzymatic activity, induced cytoskeletal reorganization Src iso1(DISRUPTS) 18809727; 20385765 6 3 1 neurite outgrowth +Ttll4 TTLL4 EC 6.-.-.-; Ligase Q80UG8 67534 1|1 C4 mouse Y815-p 1873647202 VNKKNTEyQANADET TTL enzymatic activity, induced 34084286 1 1 0 +POLB POLB DNA repair, damage; DNA replication; EC 2.7.7.7; Lyase; Transferase P06746 5423 8p11.21 human R152-m1 2363901 DFEKRIPrEEMLQMQ DNA_pol_B_palm DNA repair, induced 16600869 1 0 0 +Tsc2 TSC2 Cell cycle regulation; GAP; GAP, misc.; Nuclear receptor co-regulator; Tumor suppressor P49816 24855 10q12 rat S1381-p 450215 VDLSFQPsQPLSKSS activity, inhibited; phosphorylation translation, altered; apoptosis, inhibited 16959574 2 0 1 inhibits mTOR signaling. required for Wnt-3a to stimulation phosphorylation of S6K and 4EBP1 and increase protein levels of cyclin D1 and VEGF (cyclin D1 through translation not transcription). +Mcu MCU Membrane protein, integral; Membrane protein, multi-pass; Mitochondrial Q3UMR5 215999 10|10 B4 mouse S91-p 27259017 VISVRLPsRRERCQF apoptosis, induced 23051746 4 0 0 increase CCDC109A current and myocardial cell death +HNRNPK hnRNP K RNA splicing; RNA-binding; Spliceosome P61978 3190 9q21.32 human Y380-p 456004 YAGGRGSyGDLGGPI translation, altered 12052863 2 23 20 based on Y72/225/230/234/236/380A mutant +TP53 p53 Activator; DNA-binding; Motility/polarity/chemotaxis; Nuclear receptor co-regulator; Transcription factor; Tumor suppressor P04637 7157 17p13.1 human T304-p 50310600 HELPPGStKRALPNN intracellular localization apoptosis, induced; transcription, induced; translation, induced 26384650; 27914807 2 0 0 nuclear accumulation, p21 transcription, cleaved PARP and cytotoxicity ; T304/377D p53 induces TNF-alpha mRNA, secretion of pro-in?ammatory cytokine TNF-alpha, and apoptosis +Dppa2 DPPA2 Cancer Testis Antigen (CTA) Q9CWH0 73703 16|16 B5 mouse K108-sm 1877735401 NLSTDGKkVEVYLRL sumoylation transcription, inhibited 31226106 1 1 0 impairs early embryo development +PSMD1 PSMD1 Protease; Proteasome complex Q99460 5707 2q37.1 human Y950-p 23135657 EPPEPFEyIDD____ molecular association, regulation ADRM1(INDUCES) 31064842 1 0 1 +CENPA CENPA DNA-binding P49450 1058 2p23.3 human K49-ub 1876695602 RRRQGWLkEIRKLQK Histone protein degradation; intracellular localization cell cycle regulation 34758320 1 1 0 Ser68 facilitates degradation +SKIL SKIL Cell development/differentiation; Transcription, coactivator/corepressor P12757 6498 3q26.2 human K50-sm 3144802 INKVPTVkKEHLDDY cell differentiation, inhibited; carcinogenesis, inhibited; cell growth, inhibited; transcription, inhibited 16966324; 17202138; 28493978 3 0 0 +CTNND1 CTNND1 Actin-binding; Adaptor/scaffold; Cell adhesion; G protein regulator, misc.; Motility/polarity/chemotaxis O60716 1500 11q12.1 human T308-p 3651652 DYGTARRtGTPSDPR molecular association, regulation SMURF1(INDUCES) 32010791 1 3 4 +Akt1 Akt1 EC 2.7.11.1; KINASE; Kinase, protein; Oncoprotein; Protein kinase, AGC; Protein kinase, Ser/Thr (non-receptor) P31750 11651 12 F1|12 61.2 cM mouse Y176-p 14515900 EKATGRYyAMKILKK Pkinase intracellular localization; enzymatic activity, induced cell cycle regulation; transcription, altered 20333297 3 1 0 membrane localization +Foxp3 FOXP3 C2H2-type zinc finger protein; Cell cycle regulation; DNA-binding; Transcription factor Q99JB6 20371 X A1.1|X 3.41 cM mouse K262-ub 1875395602 MQAHLAGkMALAKAP intracellular localization 30886105 3 0 0 K262 is important for Treg function and stability +IRF3 IRF3 DNA-binding; Transcription factor Q14653 3661 19q13.33 human K193-ub 21177062 GPSENPLkRLLVPGE intracellular localization apoptosis, induced 27178468 1 4 0 +EMD emerin Cytoskeletal; Membrane protein, integral P50402 2010 Xq28 human Y34-p 10897602 VGSTRRLyEKKIFEY LEM molecular association, regulation BAF(INDUCES) 19789182 1 1 0 +CBL CBL Adaptor/scaffold; EC 6.3.2.-; EC 6.3.2.19; Ligase; Motility/polarity/chemotaxis; Oncoprotein; UBIQUITIN LIGASE; Ubiquitin conjugating system; Ubiquitin ligase P22681 867 11q23.3 human Y674-p 448874 SSSANAIySLAARPL cell motility, altered 15922744 2 34 715 Cbl mutant Y674/700/731/735/774F was used in this experiment +Rb1 Rb Nuclear receptor co-regulator; Oncoprotein; Transcription, coactivator/corepressor; Tumor suppressor P13405 19645 14 38.73 cM|14 D3 mouse S224-p 450020 VDYFIKFsPPALLRE molecular association, regulation E2F1(DISRUPTS) 10207050 3 0 0 +Src Src EC 2.7.10.2; KINASE; Kinase, protein; Oncoprotein; Protein kinase, TK; Protein kinase, tyrosine (non-receptor) Q9WUD9 83805 3q42 rat S17-p 448231 DASQRRRsLEPAENV enzymatic activity, induced cell growth, altered 15546918 10 46 12 +NR5A1 STF-1 Nuclear receptor; Transcription, coactivator/corepressor Q13285 2516 9q33.3 human K38-ac 458973 ESCKGFFkRTVQNNK zf-C4 protein stabilization; intracellular localization transcription, induced 11479297 1 1 0 localization to the cytoplasm +MAP4 MAP4 Cytoskeletal; Motility/polarity/chemotaxis P27816 4134 3p21.31 human K1034-ac 3284649 NKKVDISkVSSKCGS Tubulin-binding cytoskeletal reorganization 28002468 1 2 2 +Nfe2l2 NRF2 DNA-binding; Transcription factor Q60795 18024 2 C3|2 44.75 cM mouse S355-p 18258504 PEHSVESsIYGDPPP protein degradation; molecular association, regulation BTRC(INDUCES) 21245377 1 0 0 +NGEF ephexin-1 GEF; GEF, Rac/Rho Q5I1Y9 424744 chicken Y17-p 455579 IEHIGLLyQEYRDKS activity, induced cell motility, altered; cytoskeletal reorganization 15848799 4 0 2 +XRCC1 XRCC1 DNA repair, damage P18887 7515 19q13.31 human S578-p 40274402 GELEDYMsDRVQFVI BRCT_2 molecular association, regulation PARP1(DISRUPTS) 25477519 1 1 0 +RCAN1 RCAN1 Inhibitor P53805 1827 21q22.12 human T247-p 21511701 QTRRPEYtPIHLS__ protein stabilization transcription, inhibited PPP3CA(DISRUPTS) 21965663 2 0 0 inhibits calcineurin phosphatase activity and NFAT-dependent transcription +CD84 CD84 Cell surface; Immunoglobulin superfamily; Membrane protein, integral; Motility/polarity/chemotaxis Q9UIB8 8832 1q23.3 human Y296-p 454840 QPAESRIyDEILQSK molecular association, regulation SH2D1B(NOT_REPORTED); Arg(NOT_REPORTED) 23322602 0 14 200 +TAF5 TAF5 Q15542 6877 10q24.33 human K14-sm 12004437 EQTEVAVkLEPEGPP molecular association, regulation DNA(DISRUPTS) 15637059 1 0 0 +RPS3 RPS3 Apoptosis; EC 4.2.99.18; RNA-binding; Ribosomal; Translation P23396 6188 11q13.4 human R65-m2 9184302 VLGEKGRrIRELTAV KH_2 intracellular localization 19460357 1 0 0 regulates ribosome assembly +FEN1 FEN1 DNA repair, damage; DNA-binding; Deoxyribonuclease; EC 3.1.-.-; Nuclear receptor co-regulator; Nucleolus; Ribonuclease P39748 2237 11q12.2 human S187-p 2708400 MDCLTFGsPVLMRHL XPG_I sumoylation; protein degradation; protein stabilization; molecular association, regulation; intracellular localization; enzymatic activity, inhibited; enzymatic activity, induced cell cycle regulation; DNA repair, induced PCNA(DISRUPTS) 12853968; 18443037; 20729856; 22749529; 33770148 5 2 0 Interaction with early protein (IE1) of HCMV AD169 virus increases FEN1 phosphorylation and enhances its stability +Pld2 PLD2 EC 3.1.4.4; Lipid Metabolism - ether lipid; Lipid Metabolism - glycerophospholipid; Motility/polarity/chemotaxis; Phospholipase P97813 18806 11 B3|11 42.99 cM mouse Y14-p 453410 NLFPYGDyLNSSQLH intracellular localization 15282299 1 0 0 Y14 F and YallF showed altered location in cytoplasm rather than at the plasmamembrane. +Pxn PXN Adaptor/scaffold; Cell adhesion; Cytoskeletal; Motility/polarity/chemotaxis Q8VI36 19303 5 F|5 56.1 cM mouse S130-p 450228 KQKSAEPsPTVMSSS Paxillin cell motility, altered; cytoskeletal reorganization 16537926 5 25 4 regulates cells spreading +FFAR4 GPR120 GPCR, family 1; Lipid-binding; Membrane protein, integral; Membrane protein, multi-pass; Receptor, GPCR Q5NUL3 338557 10q23.33 human T347-p 31014807 PEKGAILtDTSVKRN activity, induced 27852822 5 1 0 +Olig2 OLIG2 Oncoprotein; Transcription factor Q9EQW6 50913 16 C3.3|16 52.6 cM mouse S14-p 18357901 LVSSRPSsPEPDDLF cell cycle regulation; cell differentiation, altered; carcinogenesis, altered; cell growth, induced; apoptosis, inhibited; transcription, induced; cell motility, inhibited 21382551; 27396340; 32483381 4 2 0 +ATF4 ATF-4 DNA-binding; Transcription factor P18848 468 22q13.1 human T119-p 40420009 LLTTLDDtCDLFAPL protein degradation transcription, inhibited 25795775 1 1 0 +AQP9 AQP9 Channel, misc.; Membrane protein, integral; Membrane protein, multi-pass; Transporter; Transporter, aquaporin family O43315 366 15q21.3 human S11-p 477183 EGAEKGKsFKQRLVL intracellular localization cell motility, induced; cytoskeletal reorganization 17346701; 21873454 2 0 0 +Nfe2l2 NRF2 DNA-binding; Transcription factor Q60795 18024 2 C3|2 44.75 cM mouse S338-p 18258501 NDSDSGIsLNTSPSR protein degradation; molecular association, regulation; activity, inhibited carcinogenesis, induced BTRC(INDUCES) 21245377; 22751928; 22964642; 24892215 4 1 0 +H3c1 H3 DNA-binding P68433 360198 13|13 A3.1 mouse K79-m1 459011 REIAQDFkTDLRFQS Histone endocytosis, altered; chromatin organization, altered; cell adhesion, altered 19434510; 33195484 16 21 41 regulation of senescence-related epigenetics modification; axon guidance +IL17RA IL17RA Membrane protein, integral; Receptor, cytokine Q96F46 23765 22q11.1 human T780-p 41452470 MVLTDPHtPYEEEQR protein degradation; ubiquitination 26871944 1 2 0 +MYL12B MRLC2 Contractile O14950 103910 18p11.31 human S20-p 448595 KRPQRATsNVFAMFD intracellular localization cell motility, altered; cytoskeletal reorganization 11781833; 12429016; 12571246; 16038801; 18984162 62 64 295 +Mip AQP0 Channel, misc.; Membrane protein, integral; Membrane protein, multi-pass; Transporter, aquaporin family P09011 25480 7q11 rat S227-p 453400 LLFPRLKsVSERLSI molecular association, regulation 22194645 3 3 0 No differences in the interaction with filensin between the AQP0 COOH-terminal peptide and its pseudophosphorylated proteins +CDC25C CDC25C EC 3.1.3.48; Motility/polarity/chemotaxis; PHOSPHATASE; Protein phosphatase, dual-specificity P30307 995 5q31.2 human S198-p 448636 SDELMEFsLKDQEAK M-inducer_phosp intracellular localization 11897663 4 1 1 +RBBP8 CtIP EC 3.1.-.-; Transcription, coactivator/corepressor Q99708 5932 18q11.2 human T847-p 7113805 FRYIPPNtPENFWEV SAE2 cell cycle regulation; DNA repair, induced; cell growth, induced; chromatin organization, altered 19202191; 31097467 7 1 1 +Mapk9 JNK2 EC 2.7.11.24; KINASE; Kinase, protein; Protein kinase, CMGC; Protein kinase, Ser/Thr (non-receptor) Q9WTU6 26420 11|11 B1.2-B1.3 mouse S129-p 456485 ELDHERMsYLLYQML Pkinase enzymatic activity, induced 16061178 1 0 0 +GORASP1 GRASP65 Vesicle Q9BQQ3 64689 3p22.2 human S189-p 25247500 AAWGGEGsLGCGIGY GRASP55_65 molecular association, regulation; protein conformation GRASP65(DISRUPTS) 22523075 1 0 0 dimer formation inhibited- substitution of two residues Glu145 and S189 rescued dimer formation, membrane tethering inhibited +H3c1 H3 DNA-binding P68433 360198 13|13 A3.1 mouse K64-m3 10338221 STELLIRkLPFQRLV Histone chromatin organization, altered; transcription, inhibited 19561610 2 0 0 +Ripk3 RIPK3 EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, Ser/Thr (non-receptor); Protein kinase, TKL Q9QZL0 56532 14|14 C3 mouse K5-ub 41259005 ___MSSVkLWPTGAS molecular association, regulation RIPK1(INDUCES) 25939025 1 2 0 induces necroptosis-mediated cell death +NEDD1 NEDD1 Cell cycle regulation Q8NHV4 121441 12q23.1 human S405-p 4706050 FDDTGKSsLGDMFSP intracellular localization cell cycle regulation; chromatin organization, altered; cytoskeletal reorganization 23273898; 31028180 3 6 1 microtubule nucleation at the central spindle during Anaphase; microtubule nucleation (vicinity of chromosomes) & spindle assembly, functional K-fibre formation, RANGTP aster formation +Vim Vimentin Cytoskeletal; Motility/polarity/chemotaxis P20152 22352 2 A1|2 10.04 cM mouse S25-p 455453 SGTSSRPsSNRSYVT Filament_head cytoskeletal reorganization 12458200 2 20 1 +DLC1 DLC1 GAP; GAP, Rac/Rho; Tumor suppressor Q96QB1 10395 8p22 human S859-p 37038505 RRENSSDsPKELKRR activity, induced; intracellular localization; protein conformation carcinogenesis, inhibited; cell growth, inhibited; cell motility, inhibited talin 1(INDUCES); tensin 1 iso1(INDUCES) 25452387 1 1 0 localize to focal adhesions; activates Rho-GAP activity +EIF4EBP1 4E-BP1 Translation; Translation initiation Q13541 1978 8p11.23 human T70-p 447528 RNSPVTKtPPRDLPT eIF_4EBP molecular association, regulation; protein conformation; activity, inhibited; phosphorylation cell cycle regulation; carcinogenesis, induced; cell motility, induced; transcription, altered; translation, altered; cell growth, induced; autophagy, inhibited; translation, induced; translation, inhibited 4E-BP1(DISRUPTS); EIF4E(DISRUPTS) 11410517; 11553333; 12588975; 15051500; 24247720; 25702871; 26170285; 27065332; 33658337; 35626002 55 57 9 +PRKCE PKCE EC 2.7.11.13; KINASE; Kinase, protein; Protein kinase, AGC; Protein kinase, Ser/Thr (non-receptor) Q02156 5581 2p21 human S729-p 448789 QEEFKGFsYFGEDLM Pkinase_C sumoylation; molecular association, regulation; intracellular localization; enzymatic activity, induced cell growth, induced AKAP9(DISRUPTS) 10945988; 11964154; 21806543; 33027667 20 17 7 +TRPC6 TRPC6 Channel, cation; Membrane protein, integral; Membrane protein, multi-pass Q9Y210 7225 11q22.1 human S14-p 4959823 FGPRRGSsPRGAAGA intracellular localization 28877958 2 2 2 plasma membrane expression +Ywhaz 14-3-3 zeta Adaptor/scaffold; Motility/polarity/chemotaxis P63101 22631 15|15 B3.1 mouse S58-p 449833 VVGARRSsWRVVSSI 14-3-3 molecular association, regulation; intracellular localization apoptosis, induced 14-3-3 zeta(DISRUPTS) 12865427; 20813501; 21189996 15 1 5 +GATA1 GATA1 DNA-binding; Transcription factor P17678 396450 chicken K220-ac 459194 RKVSSKGkKRRPPGG molecular association, regulation; protein conformation cell differentiation, induced; transcription, induced DNA(INDUCES) 9859997 3 1 0 +TP63 p63 DNA-binding; Transcription factor Q9H3D4 8626 3q28 human K232-ac 41259001 IRAMPVYkKAEHVTE P53 protein stabilization transcription, induced 25911675 1 0 0 +CDK5 CDK5 Cell cycle regulation; EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, CMGC; Protein kinase, Ser/Thr (non-receptor) Q00535 1020 7q36.1 human S159-p 448021 GIPVRCYsAEVVTLW Pkinase enzymatic activity, induced 10500146 6 0 0 Cdk5 is activated after phosphorylation by CK1 in vitro. +JUN Jun Oncoprotein; Transcription factor P05412 3725 1p32.1 human S73-p 447943 VGLLKLAsPELERLI Jun activity, induced; acetylation; protein stabilization; molecular association, regulation; enzymatic activity, induced cell cycle regulation; carcinogenesis, induced; cell motility, induced; cell growth, induced; transcription, induced; transcription, altered; cell growth, altered TCF4(INDUCES); HDAC3(DISRUPTS); JNK1(DISRUPTS); MBD3(DISRUPTS); PIN1(INDUCES); NFkB-p65(INDUCES) DNA(INDUCES); DNA(DISRUPTS) 11313929; 11432833; 11739718; 12040039; 12853483; 1496019; 15378002; 18443042; 19118012; 1922387; 20395206; 23720779; 26745678; 26755651; 33767435; 34703881; 36253406; 7737130; 7744008; 8072547; 8224842; 9022811 84 65 16 +SAMHD1 SAMHD1 EC 3.1.4.- Q9Y3Z3 25939 20q11.23 human K354-ac 1883981500 LRICARDkEVGNLYD acetylation; intracellular localization DNA repair, inhibited 36344525 1 1 0 deacetylation promotes genome stability; K354 deacetylation facilitates SAMHD1 localization to DSBs and SAMHD1 residues 300?465; K354 deacetylation by SIRT1 promotes HR and DNA end resection +NCOA3 SRC-3 ACETYLTRANSFERASE; Acetyltransferase; EC 2.3.1.48; Motility/polarity/chemotaxis; Nuclear receptor co-regulator; Transcription, coactivator/corepressor Q9Y6Q9 8202 20q13.12 human S509-p 482840 GVHSPMAsSGNTGNH NCOA_u2 activity, induced; protein degradation; molecular association, regulation; ubiquitination; phosphorylation transcription, induced; signaling pathway regulation ER-alpha(INDUCES) 17574025 1 0 0 induces ubiquitination, degradation of SRC-3, and its interaction with ER. +JUNB JunB Motility/polarity/chemotaxis; Oncoprotein; Transcription factor P17275 3726 19p13.13 human S251-p 465702 QTVPEARsRDATPPV Jun protein degradation FBXW7(INDUCES) 22710716 1 37 7 mitosis progression and chromatid cohesion +RG1 PPP1R3A Membrane protein, integral; Protein phosphatase, regulatory subunit Q00756 100009140 rabbit S67-p 449321 SSGGRRVsFADNFGF molecular association, regulation PPP1CA(DISRUPTS) 10657242 6 1 0 +RRAGC RRAGC Q9HB90 64121 1p34.3 human T394-p 6732849 KALTHNGtPRNAI__ molecular association, regulation; phosphorylation cell growth, induced; autophagy, inhibited Raptor(INDUCES); mTOR(DISRUPTS) 30552228 1 13 18 induces Ulk1 and p70S6K phosphorylation, regulates mTORC1 raptor complex stability +LASP1 Lasp-1 Actin-binding; Motility/polarity/chemotaxis Q14847 3927 17q12 human S146-p 448836 MEPERRDsQDGSSYR molecular association, regulation; intracellular localization; protein conformation; phosphorylation carcinogenesis, induced Zyxin(DISRUPTS); LPP(INDUCES); AGO2(DISRUPTS); CXCR4(INDUCES); Akt1(INDUCES) 12571245; 22665060; 32075106; 32872485 6 33 135 inhibits phosphorylation at Y171 +EXO5 DEM1 EC 3.1.11.- Q9H790 64789 1p34.2 human T88-p 1874115104 LYVTDLAtQNWCELQ Exo5 molecular association, regulation; enzymatic activity, inhibited DNA repair, induced BLM(INDUCES) DNA(DISRUPTS) 34197737 1 0 0 +H4C1 H4 DNA-binding P62805 8359 6p22.2 human Y72-p 475134 VIRDAVTyTEHAKRK CENP-T_C molecular association, regulation; methylation DNA repair, induced SUV420H1(INDUCES); SETD8(INDUCES); EGFR(DISRUPTS) 25073158 1 7 145 disruption of interaction with EGFR and reduced tumor mass in mice treated with the Y72 peptide +CSNK1D CK1D EC 2.7.11.1; EC 2.7.11.26; KINASE; Kinase, protein; Protein kinase, CK1; Protein kinase, Ser/Thr (non-receptor) P48730 1453 17q25.3 human T347-p 3190852 VAPPTPLtPTSHTAN enzymatic activity, induced 28545154 1 15 7 +Pdgfrb PDGFRB EC 2.7.10.1; KINASE; Kinase, protein; Membrane protein, integral; Oncoprotein; Protein kinase, TK; Protein kinase, tyrosine (receptor) P05622 18596 18 E1|18 34.41 cM mouse Y578-p 447521 VSSDGHEyIYVDPVQ molecular association, regulation PLCG1(INDUCES) 11281646 11 1 0 +MEFV pyrin Actin-binding O15553 4210 16p13.3 human S209-p 455898 RLRRNASsAGRLQGL molecular association, regulation; intracellular localization 14-3-3 theta(INDUCES) 15934090 2 0 0 +NCL NCL DNA-binding; Helicase; Nuclear receptor co-regulator; Nucleolus; RNA-binding P19338 4691 2q37.1 human T76-p 483581 TKKVAVAtPAKKAAV molecular association, regulation cell cycle regulation; cell motility, induced; cell growth, induced DDX31(INDUCES) 29440146; 30320343; 37276927 5 33 23 +CTCF CTCF C2H2-type zinc finger protein; Transcription factor; Tumor suppressor P49711 10664 16q22.1 human K74-sm 6124703 DPTLLQMkTEVMEGT transcription, induced 22354964 2 1 0 +Creb1 CREB iso1 DNA-binding; Transcription factor P15337-1 81646 9q32 rat S129-p 450092 QKRREILsRRPSYRK pKID transcription, induced 11796524; 12162494; 7798217 10 0 2 Ser to Ala substitution of residue 129 impairs cAMP-induced transcriptional response +DOC2B DOC2B Lipid-binding Q14184 8447 17p13.3 human Y301-p 5466714 AAMDANGySDPYVKT C2 molecular association, regulation KLC1(INDUCES) 30707251 1 0 1 increase GLUT4 translocation, important for Glucose uptake and protect cells against InsRes stimuli +Ppargc1a PGC-1 alpha Nuclear receptor co-regulator; Transcription, coactivator/corepressor O70343 19017 5|5 C1 mouse T256-p 13861600 HAQAKPTtLSLPLTP intracellular localization transcription, induced 20351112 1 0 0 +Asf1a ASF1A DNA repair, damage; Histone-binding Q9CQE6 66403 10|10 B3 mouse S166-p 3245981 KLEDAESsNPNLQSL cell differentiation, induced 28708136 2 11 2 +Apba1 APBA1 Adaptor/scaffold B2RUJ5 319924 19|19 B mouse Y202-p 23082644 GGLQEHVyEEIGDAP intracellular localization 26865271 1 1 6 neuronal trafficking of amyloid precursor protein (APP) +PJA2 PJA2 EC 6.3.2.-; EC 6.3.2.19; Ligase; UBIQUITIN LIGASE; Ubiquitin conjugating system; Ubiquitin ligase O43164 9867 5q21.3 human S342-p 18713700 RHEAKQRsVQRWREA ubiquitination; enzymatic activity, induced signaling pathway regulation 21423175 1 0 0 S342A/T389A mutant fails to ubiquitylate PKAR2A in vitro +SP1 SP1 C2H2-type zinc finger protein; DNA-binding; Transcription factor P08047 6667 12q13.13 human S732-p 2535903 PLDSGAGsEGSGTAT protein degradation; molecular association, regulation; ubiquitination cell growth, inhibited; apoptosis, induced; signaling pathway regulation; transcription, inhibited BTRC(INDUCES) 18239466; 19372209; 30181396 3 0 0 also inhibits stabilization of B-Catennin thus regulating Wnt signaling +Esr2 ER-beta DNA-binding; Nuclear receptor O08537 13983 12 C3|12 33.52 cM mouse S61-gl 5148302 MNYSVPSsTGNLEGG ERbeta_N protein degradation; protein stabilization; protein conformation transcription, altered 11150304; 16984883 2 1 0 phosphorylation results in accelerated degradation, while O-Glycosylation would be predicted to result in stabilization, both localized in nucleus +SGK1 SGK1 EC 2.7.11.1; KINASE; Kinase, protein; Motility/polarity/chemotaxis; Protein kinase, AGC; Protein kinase, Ser/Thr (non-receptor) O00141 6446 6q23.2 human S422-p 448429 AEAFLGFsYAPPTDS Pkinase_C molecular association, regulation; intracellular localization; phosphorylation; enzymatic activity, induced cell cycle regulation; cell growth, inhibited; apoptosis, inhibited; transcription, inhibited; signaling pathway regulation 10191262; 11096081; 11832334; 11956329; 18456663; 19232516; 25384981; 30837283; 33890983; 34679726; 35588785 30 0 0 induces NDRG1 phosphorylation +Msx1 MSX1 DNA-binding; Motility/polarity/chemotaxis P13297 17701 5 B3|5 20.21 cM mouse K133-sm 12004421 LPEDALVkAESPEKL cell differentiation, inhibited; transcription, inhibited 16600910 2 0 0 PIAS1 binding to MSX1 is required for inhibiting cell differentiation and transcriptional repression, but sumoylation is not required +NHERF1 NHERF Adaptor/scaffold; Motility/polarity/chemotaxis O14745 9368 17q25.1 human S77-p 957200 ETHQQVVsRIRAALN PDZ molecular association, regulation; intracellular localization SLC34A1(DISRUPTS); ADRA2B(DISRUPTS) 17895247; 20571032 4 0 0 +Gabrb2 GABRB2 Channel, chloride; Channel, ligand-gated; Membrane protein, integral; Membrane protein, multi-pass; Transporter; Transporter, ion channel P63138 25451 10q21 rat S434-p 449329 SRLRRRAsQLKITIP Neur_chan_memb intracellular localization 12818177 1 0 1 +SP3 SP3 C2H2-type zinc finger protein; DNA-binding Q02447 6670 2q31.1 human K120-sm 3681500 SATPTTIkDEAGNLV intracellular localization; activity, inhibited transcription, inhibited 12419227 1 1 0 +ZFP36 TTP DNA-binding; RNA-binding P26651 7538 19q13.2 human S186-p 451151 PVLRQSIsFSGLPSG protein degradation; molecular association, regulation; ubiquitination carcinogenesis, induced; RNA stability, induced RNA(INDUCES) 28548957; 37210725 13 25 11 +MAPK14 P38A EC 2.7.11.24; KINASE; Kinase, protein; Protein kinase, CMGC; Protein kinase, Ser/Thr (non-receptor) Q16539 1432 6p21.31 human T180-p 447970 RHTDDEMtGYVATRW Pkinase activity, induced; molecular association, regulation; phosphorylation; enzymatic activity, induced cell cycle regulation; carcinogenesis, induced; apoptosis, altered; apoptosis, induced; signaling pathway regulation; cell growth, induced; cell motility, altered; transcription, inhibited; carcinogenesis, inhibited; cell growth, inhibited; transcription, induced; autophagy, induced; cell differentiation, induced; cytoskeletal reorganization; cell adhesion, altered; autophagy, inhibited PPP2CA(NOT_REPORTED); NCK1(INDUCES); MEK1(NOT_REPORTED); Fyn(INDUCES); P38A(INDUCES) 10201954; 10867021; 11994493; 15944157; 15972258; 16966330; 17438131; 17548358; 18047584; 18560558; 19336399; 21177868; 21878628; 22039048; 33685990; 34048499; 34209868; 34995286; 35189144; 35569509; 35849202; 36219392; 36289618; 8622669 401 73 1542 autoamplifcation of NFAT-c1, which promotes osteoclast differentiation, suppressed by MLN4924 +API5 API5 Apoptosis; RNA-binding Q9BZZ5 8539 11p12 human K251-ac 11322946 QAVPLFSkNVHSTRF API5 protein stabilization; intracellular localization cell cycle regulation 34385547 1 1 0 nuclear localization +Notch1 Notch 1 Membrane protein, integral; Motility/polarity/chemotaxis; Oncoprotein; Receptor, misc.; Transcription factor Q01705 18128 2 A3|2 18.91 cM mouse S2152-p 3252805 GKKARKPsTKGLACG intracellular localization cell motility, induced; cell growth, induced 27281612 1 2 3 nuclear localization +OCLN occludin Cell adhesion; Membrane protein, integral; Membrane protein, multi-pass; Motility/polarity/chemotaxis Q16625 100506658 5q13.2 human T424-p 19083406 IREYPPItSDQQRQL Occludin_ELL intracellular localization 21545357 1 0 0 facilitates assembly of occludin into tight junction +CHUK IKKA EC 2.7.11.10; KINASE; Kinase, protein; Protein kinase, Other; Protein kinase, Ser/Thr (non-receptor) O15111 1147 10q24.31 human S473-p 487499 KNTLISAsQQLKAKL IKBKB_SDD protein stabilization 17700524 1 0 0 +KCNC4 Kv3.4 Channel, potassium; Membrane protein, integral; Membrane protein, multi-pass Q03721 3749 1p13.3 human S15-p 451077 SSYRGRKsGNKPPSK Potassium_chann receptor inactivation, altered; protein conformation; activity, inhibited 7993631; 9649584 2 0 0 +DBF4 DBF4 Cell cycle regulation; Protein kinase, regulatory subunit Q9UBU7 10926 7q21.12 human T449-p 23010416 DDIRQNFtQLPLHKN cell cycle regulation 22123827 1 0 0 DBF4 phosphorylaion is important for supressing DNA replication. +TERF1 TRF1 DNA-binding P54274 7013 8q21.11 human T344-p 3793900 KKERRVGtPQSTKKK phosphorylation 18625707 2 1 0 stimulates phosphorylation of residue S435 +Acly ACLY Carbohydrate Metabolism - citrate (TCA) cycle; EC 2.3.3.8; Lyase; Transferase Q91V92 104112 11|11 D mouse S455-p 448631 PAPSRTAsFSESRAD transcription, inhibited 33865855 10 83 122 +BAP1 BAP1 DEUBIQUITINASE; EC 3.4.19.12; Protease; Tumor suppressor; Ubiquitin conjugating system; Ubiquitin-specific protease Q92560 8314 3p21.1 human S583-p 482082 TEGGKGSsPSIRPIQ intracellular localization DNA repair, induced 24347639 1 8 3 +Kirrel1 KIRREL Cell adhesion; Membrane protein, integral Q80W68 170643 3|3 F1 mouse Y638-p 463752 KDPTNGYyNVRAHED molecular association, regulation cytoskeletal reorganization GRB2(INDUCES) 17923684; 34391780 3 5 49 induce podocyte repair +H3-3A H3F3A DNA-binding P84243 3020 1q42.12 human K27-ac 18545312 LATKAARkSAPSTGG Histone phosphorylation 16185088 1 3 21 detecting S10 phosphorylation with phospho-antibody was disrupted in dual modified peptides with K9ac and K9 monomethyl as was S28 with K27ac +Odf1 ODFP1 Cancer Testis Antigen (CTA) P21769 24610 7q22 rat S193-p 2859801 SPCYPCTsPCNPCNP molecular association, regulation RNF38(INDUCES) 17762160 1 0 0 +TSC1 TSC1 Motility/polarity/chemotaxis; Tumor suppressor Q92574 7248 9q34.13 human S468-p 36132604 GFLGDLAsEEDSIEK Hamartin intracellular localization cell cycle regulation; cell growth, altered 29559472 1 2 0 decreased lysosomal localization of the TSC complex +EPHB2 EphB2 EC 2.7.10.1; KINASE; Kinase, protein; Membrane protein, integral; Protein kinase, TK; Protein kinase, tyrosine (receptor); Tumor suppressor P29323 2048 1p36.12 human Y504-p 139835700 GLKAGAIyVFQVRAR fn3 molecular association, regulation; intracellular localization NMDAR1(INDUCES) 28719605 1 1 0 cell surface,retain NMDARs to spine synapse, pathological pain, mechanical hypersensitivity +IQGAP1 IQGAP1 GAP; GAP, Ras; Motility/polarity/chemotaxis P46940 8826 15q26.1 human S1443-p 454416 DKMKKSKsVKEDSNL molecular association, regulation; protein conformation; phosphorylation cytoskeletal reorganization; cell adhesion, inhibited; endocytosis, inhibited RAC1(DISRUPTS); CDC42 iso1(DISRUPTS); CDC42(INDUCES); RAC1(INDUCES); RAB27A(DISRUPTS) 15355962; 15695813; 21349850; 27815503; 28739799; 31474712 5 17 3 glucose-induced endocytosis +HDAC6 HDAC6 DEACETYLASE; Deacetylase; EC 3.5.1.98; Nuclear receptor co-regulator; Ubiquitin conjugating system Q9UBN7 10013 Xp11.23 human Y570-p 12127406 SSNFDSIyICPSTFA Hist_deacetyl enzymatic activity, inhibited 20029029 1 0 1 +Nr1h3 LXR-alpha DNA-binding; Motility/polarity/chemotaxis; Nuclear receptor Q9Z0Y9 22259 2 E1|2 50.52 cM mouse K326-sm 12004412 YNREDFAkAGLQVEF Hormone_recep protein degradation; ubiquitination 33125792 2 0 0 Sumoylation of LXR-alpha is necessary for polyubiquitylation and interaction with pSTAT1 and PIAS1 for degradation induced by IFN-gamma. May inhibit cholesterol effux mediated by ABCG1 from macrophages. +Nkx3-2 NKX3-2 Cell development/differentiation; DNA-binding; Transcription factor P97503 12020 5 B3|5 22.58 cM mouse S168-p 20473602 RGEDDSVsPGGARVP molecular association, regulation; ubiquitination apoptosis, inhibited BTRC(INDUCES) 21606193 1 1 0 phosphorylation of S148/S168 causes ubiquitination of IkB-alpha. +INSR INSR EC 2.7.10.1; KINASE; Kinase, protein; Membrane protein, integral; Protein kinase, TK; Protein kinase, tyrosine (receptor) P06213 3643 19p13.2 human S1333-p 451591 NVPLDRSsHCQREEA enzymatic activity, inhibited 8454604 2 0 0 +ELAVL1 HuR RNA-binding Q15717 1994 19p13.2 human S158-p 478356 FIRFDKRsEAEEAIT RRM_1 molecular association, regulation; intracellular localization; phosphorylation translation, altered; RNA stability, altered PKCA(INDUCES) RNA(INDUCES) 17392515; 23978401 3 0 0 ELAV1 is exported from the nucleus after phosphorylation by PKCA. ; increased binding to U-rich RNA but not AU-rich sequences +Mapk7 ERK5 EC 2.7.11.24; KINASE; Kinase, protein; Protein kinase, CMGC; Protein kinase, Ser/Thr (non-receptor) Q9WVS8 23939 11|11 B2 mouse K6-sm 2887213 __MAEPLkEEDGEDG molecular association, regulation apoptosis, induced; transcription, inhibited; signaling pathway regulation SRC-1(DISRUPTS) 18218985; 18467627 4 0 0 +ARFIP2 arfaptin 2 GAP; GAP, Rac/Rho; Motility/polarity/chemotaxis P53365 23647 11p15.4 human S260-p 455884 GTRGRLEsAQATFQA Arfaptin intracellular localization 15809304 1 3 4 phosphorylation of site by Akt1 has a neuroprotective effect in Huntington's disease. +TENT2 PAPD4 EC 2.7.7.19; RNA processing; Transferase Q6PIY7 167153 5q14.1 human S116-p 50785745 LSGERRYsMPPLFHT molecular association, regulation; enzymatic activity, inhibited; enzymatic activity, altered RNA stability, altered RNA(DISRUPTS) 31057087; 34288801 2 2 0 +CD300LF IREM-1 Immunoglobulin superfamily; Membrane protein, integral; Receptor, misc. Q8TDQ1 146722 17q25.1 human Y263-p 474549 AEDQEPTyCNMGHLS activity, induced; molecular association, regulation PIK3R1(INDUCES) 17202342 2 0 0 involved in rat basophilic leukemia cell degranulation +JUNB JunB Motility/polarity/chemotaxis; Oncoprotein; Transcription factor P17275 3726 19p13.13 human Y188-p 41655505 VYTNLSSySPASASS Jun transcription, induced 26217035 1 1 0 p21 promoter activity upon Adriamycin stimulation +Pdx1 PDX1 DNA-binding; Transcription factor P52946 18609 5 G3|5 86.84 cM mouse S269-p 11279404 LPSGLSVsPQPSSIA protein stabilization; intracellular localization 20637728; 23331010 3 4 0 +SPRR2B SPRR2B P35325 6701 1q21.3 human Y67-p 5233872 SPPCQPKyPPKSK__ SPRR2 molecular association, regulation cell cycle regulation USP7(INDUCES) 29581288 1 0 1 facilitated complex formation with USP7 and p53 degradation in response to TGF-beta1/H2O2 +Map2 MAP2 iso3 Cytoskeletal; Motility/polarity/chemotaxis P15146-3 25595 9q32 rat K347-ac 62495516 DLSHVTSkCGSLKNI Tubulin-binding cytoskeletal reorganization 28002468 1 1 0 +Mcl1 MCL1 Apoptosis; Channel, misc.; Inhibitor; Membrane protein, integral; Mitochondrial P97287 17210 3 F2.1|3 40.74 cM mouse S140-p 460683 KSSGADGsLPSTPPP protein degradation; molecular association, regulation; ubiquitination autophagy, induced beclin 1(DISRUPTS) 26822034; 28053206 17 7 2 dissasociates after phosphorylation and ubiquitylation of MCL1 at K117, K175, K178 +Tln1 talin 1 Cytoskeletal; Motility/polarity/chemotaxis P26039 21894 4|4 A5 mouse S1589-p 27533485 SSVPAQIsPEGRAAM molecular association, regulation; protein conformation ANKRD15(DISRUPTS) 34118235 1 7 0 +CTBP1 CTBP1 Cell cycle regulation; EC 1.1.1.-; Nuclear receptor co-regulator; Oxidoreductase; Transcription, coactivator/corepressor Q13363 1487 4p16.3 human S100-p 2089801 RIIVRIGsGFDNIDI 2-Hacid_dh molecular association, regulation SF1(INDUCES) 18184656 1 1 0 +SUPT5H SPT5 RNA-binding; Transcription, coactivator/corepressor O00267 6829 19q13.2 human T799-p 458818 PLQDGSRtPHYGSQT transcription, altered 16427012 1 9 40 required for c-fos induction and activation in vivo +CENPU CENPU Cell cycle regulation Q71F23 79682 4q35.1 human T78-p 471408 FDPPLHStAIYADEE protein degradation; molecular association, regulation; intracellular localization cell cycle regulation; carcinogenesis, induced; cell motility, induced; cell growth, induced; signaling pathway regulation; cell growth, altered CENPQ(INDUCES); PLK1(INDUCES) 17081991; 21454580; 34094674; 34551298 4 1 0 COX-2/HIF-1a/VEGFA signaling pathway; PLK1 phosphorylates CENPU T78 and then is recruited to form a ternary complex with CENPU and CENPQ, then PLK1 phosphorylates CENPQ which dissasociates the complex.; p-T78 peptides precipitated with Pl1K. Kinase activity of Plk1 is necessary for the in vivo interaction. The S77- T78 dependent interaction is sufficient to target Plk1 to the kinetochores. P-T78 dependent PBIP1 function is required for chromosome segregation, and is important for activation of spindle assembly checkpoint.; induces PLK1 recruitment +Pparg PPAR-gamma DNA-binding; Nuclear receptor; Transcription factor P37238 19016 6 E3|6 53.41 cM mouse K268-ub 1877844704 ARAILTGkTTDKSPF protein degradation; ubiquitination cell differentiation, inhibited 31653699 1 1 0 +IKZF1 Ikaros C2H2-type zinc finger protein; DNA-binding; Transcription factor Q13422 10320 7p12.2 human S391-p 451350 SEREASPsNSCQDST cell cycle regulation; cell growth, induced 27026320 2 1 2 +SOX2 SOX2 Cell development/differentiation; DNA-binding; Transcription factor P48431 6657 3q26.33 human K115-ub 1878299900 YKYRPRRkTKTLMKK protein degradation 30894683 1 0 0 AKT1 phosphorylation at T116 blocks UBR5-induced ubiquitination at K115 of SOX2 +Gabrg2 GABRG2 Channel, chloride; Channel, ligand-gated; Membrane protein, integral; Membrane protein, multi-pass; Transporter; Transporter, ion channel Q6PW52 29709 10q21 rat Y411-p 455817 LQERDEEyGYECLDG Neur_chan_memb molecular association, regulation; receptor internalization, inhibited neural plasticity; endocytosis, inhibited Src(INDUCES); AP-2 alpha(DISRUPTS) 11640929; 18305175 7 0 0 +PDP1 PDP1 EC 3.1.3.43; Mitochondrial; Motility/polarity/chemotaxis; PHOSPHATASE; Protein phosphatase, Ser/Thr (non-receptor) Q9P0J1 54704 8q22.1 human K202-ac 11323780 HPNDYFSkEASKLYF PP2C molecular association, regulation cell growth, induced PDHA1(INDUCES) 24486017 2 2 0 glycolysis, cancer cell proliferation +HNRNPA1 hnRNP A1 Nuclear export; RNA splicing; RNA-binding; Spliceosome P09651 3178 12q13.13 human S4-p 468002 ____MSKsESPKEPE sumoylation; molecular association, regulation; intracellular localization apoptosis, inhibited; translation, induced 14-3-3 sigma(INDUCES); 14-3-3 theta(INDUCES) RNA(INDUCES) 25324306 2 48 2 interaction with BCL-XL and XIAP mRNA and regulation of their translation; nuclear import/export +Sort1 SORT1 Membrane protein, integral; Receptor, misc. Q6PHU5 20661 3|3 F2.3-F3 mouse S791-p 3823097 RFLVHRYsVLQQHAE protein degradation 24986865 3 8 0 +ACD ACD Adaptor/scaffold Q96AP0 65057 16q22.1 human S25-p 3208632 LGSETPSsPRAGQLL TPP1 molecular association, regulation; enzymatic activity, inhibited cell cycle regulation TERT(INDUCES) 23509301 1 19 1 shortened telomere length +Hes1 HES1 Cell development/differentiation; Motility/polarity/chemotaxis; Transcription factor Q04666 29577 11q22 rat S263-p 23298200 SVGPNAVsPSSGSSL protein stabilization 22302822 1 0 0 decreases AMPA-evoked calcium influx; supresses GluR1 expression at the synaptic membrane +Gria2 GluR2 Channel, calcium; Channel, ligand-gated; Membrane protein, integral; Membrane protein, multi-pass P23819 14800 3 E3|3 35.5 cM mouse Y876-p 452173 YKEGYNVyGIESVKI molecular association, regulation neural plasticity IQSEC1(DISRUPTS) 15240807; 20547133; 32071234 9 5 109 +Slc6a5 SLC6A5 Membrane protein, integral; Membrane protein, multi-pass; Transporter; Transporter, SLC family P58295 171148 1q22 rat K787-ub 27209761 GTSSLGLkLPVKDLE protein degradation; ubiquitination; intracellular localization endocytosis, induced; transcription, altered 23484054; 31628376 2 1 0 LNX2 mediated degradation was slower and seen after 48 hours, PKC regulation of SLC6A5 activity, modulation in the glycine transport activity of SLC6A5 +Sirt1 SIRT1 Apoptosis; DEACETYLASE; Deacetylase; EC 3.5.1.-; Nuclear receptor co-regulator Q923E4 93759 10|10 B4 mouse S651-p 6855924 GAEVYSDsEDDVLSS enzymatic activity, induced apoptosis, inhibited 19680552 2 0 0 deacetylates p53 K382 and NFkB-p65 +Kcnn4 KCNN4 Channel, potassium; Membrane protein, integral; Membrane protein, multi-pass Q9QYW1 65206 1q21 rat T348-p 452146 KMLAAIHtFRQVRLK CaMBD activity, inhibited 15243742 1 0 0 +RARA RARA DNA-binding; Nuclear receptor; Oncoprotein; Transcription factor P10276 5914 17q21.2 human K171-sm 10902801 KKKKEVPkPECSESY transcription, induced 19850744 1 0 0 +TLR3 TLR3 Membrane protein, integral; Receptor, cytokine O15455 7098 4q35.1 human Y858-p 25680401 FLEEIPDyKLNHALC TIR molecular association, regulation signaling pathway regulation TICAM1(INDUCES) 22810896 1 0 0 antiviral TLR3 signaling +Mapk14 P38A EC 2.7.11.24; KINASE; Kinase, protein; Protein kinase, CMGC; Protein kinase, Ser/Thr (non-receptor) P47811 26416 17 A3.3|17 14.85 cM mouse Y182-p 447971 TDDEMTGyVATRWYR Pkinase molecular association, regulation; protein conformation; phosphorylation; enzymatic activity, induced cell cycle regulation; carcinogenesis, inhibited; cell growth, inhibited; apoptosis, induced; cell motility, inhibited; transcription, induced; signaling pathway regulation; transcription, altered; cell growth, induced; cell differentiation, induced PKCZ(INDUCES) 10867029; 12032135; 15665819; 15975986; 16648139; 18669639; 21847090; 25098293; 26517532; 33798451; 34560245; 35112724; 35637461; 36310322; 36642184 410 123 3683 +G6PD G6PD Carbohydrate Metabolism - pentose phosphate pathway; Cell development/differentiation; EC 1.1.1.49; Other Amino Acids Metabolism - glutathione; Oxidoreductase P11413 2539 Xq28 human Y112-p 455132 NSYVAGQyDDAASYQ G6PD_N enzymatic activity, induced carcinogenesis, induced; cell growth, induced 33686238 1 12 344 +MRE11 MRE11A Cell cycle regulation; DNA repair, damage; DNA-binding; Deoxyribonuclease P49959 4361 11q21 human T597-p 4333497 SQRGRADtGLETSTR protein degradation 28967905 1 3 23 +Afap1l1 AFAP1L1 Unknown function Q8BZI0 106877 18|18 E1 mouse Y127-p 41691500 KPPPEDYyEEALPLG molecular association, regulation cell motility, induced; cytoskeletal reorganization VAV2(INDUCES) 26212012 1 0 0 +Cyld CYLD DEUBIQUITINASE; EC 3.4.19.12; Protease; Tumor suppressor; Ubiquitin conjugating system; Ubiquitin-specific protease Q80TQ2 74256 8|8 C3 mouse S414-p 4745557 SSENRFHsLPFSLTK CYLD_phos_site enzymatic activity, inhibited cell growth, induced; apoptosis, inhibited 19481526; 34887354 5 31 22 +ITGB3BP NRIF3 Cell adhesion; Motility/polarity/chemotaxis; Nuclear receptor co-regulator; Transcription, coactivator/corepressor Q13352 23421 1p31.3 human S28-p 2840505 SKITRKKsVITYSPT CENP-R activity, induced; molecular association, regulation apoptosis, induced; transcription, induced; cell growth, altered ER-alpha(INDUCES) 18521086; 25409762 2 2 0 +DNM1L DRP1 Apoptosis; EC 3.6.5.5; Endoplasmic reticulum; Hydrolase; Microtubule-binding; Mitochondrial; Motor O00429 10059 12p11.21 human Y368-p 15569023 CGGARICyIFHETFG Dynamin_M activity, induced 29022905 1 0 2 oxidative stress-induced cell death in primary cortical neuron; increased GTPase activity +Junb JunB Motility/polarity/chemotaxis; Oncoprotein; Transcription factor P24898 24517 19q11 rat S23-p 1814002 AAAGYGRsPGSLSLH Jun protein degradation cell cycle regulation; transcription, altered 10790372 1 7 0 Phosphorylation promoted degradation during the G2-M transition. JunB inhibition of cyclin D1 transcription is relieved by JunB protein degradation. +CAD CAD Amino Acid Metabolism - alanine, aspartate and glutamate; EC 2.1.3.2; EC 3.5.2.3; EC 6.3.5.5; Hydrolase; KINASE; Ligase; Nucleotide Metabolism - pyrimidine; Transferase P27708 790 2p23.3 human S1859-p 451247 PPRIHRAsDPGLPAE enzymatic activity, induced carcinogenesis, induced; cell growth, induced 23429703; 31391321; 35046532 11 88 86 +KCTD12 KCTD12 Unknown function Q96CX2 115207 13q22.3 human S243-p 18011104 ITVCGKTsLAKEVFG molecular association, regulation cell growth, induced CDK1(INDUCES) 28869606 1 2 0 +DAPK3 DAPK3 EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, CAMK; Protein kinase, Ser/Thr (non-receptor); Tumor suppressor O43293 1613 19p13.3 human T180-p 454890 EFKNIFGtPEFVAPE Pkinase enzymatic activity, induced 15611134 1 0 0 +FUS hnRNP P2 DNA-binding; Nuclear receptor co-regulator; Oncoprotein; RNA splicing; RNA-binding; SUMO LIGASE P35637 2521 16p11.2 human S61-p 3306334 SYSSYGQsQNTGYGT molecular association, regulation; protein conformation hnRNP P2(DISRUPTS) 28942918; 31805282 6 1 0 strongly reduced the effects of DNA-PK treatment on both hydrogel binding and droplet formation; inhibits amyloid segment aggregation, fibrillization and seeding processes; disrupt the intra and intermolecular interactions to inhibit the aggregation of R2 +Hnf4a HNF4 alpha DNA-binding; Nuclear receptor; Transcription factor P49698 15378 2 H3|2 84.32 cM mouse K458-ac 25336501 GAITTIVkPPSAIPQ protein degradation 33636024 2 2 0 SIRT2 interacts with HNF4-alpha and suppresses its degradation. Deacetylation is required for HNF-alpha stability. +Srsf1 SF2 RNA splicing; RNA-binding; Spliceosome NP_001103022 689890 10q26 rat S227-p 2303915 NSRSRSYsPRRSRGS intracellular localization 18658135 3 20 2 inhibits tau exon 10 inclusion, and increases 3R-tau production +Stmn1 STMN1 Cytoskeletal P13668 29332 5q36 rat S25-p 448555 QAFELILsPRSKESV Stathmin apoptosis, inhibited; cytoskeletal reorganization 25285524; 31933182 52 122 91 increase microtubule depolymerization +TRIM25 TRIM25 EC 6.3.2.19; EC 6.3.2.n3; Ligase; Nuclear receptor co-regulator; Transcription factor; UBIQUITIN LIGASE; Ubiquitin conjugating system; Ubiquitin ligase Q14258 7706 17q22 human Y278-p 450585 NSKFDTIyQILLKKK ubiquitination; enzymatic activity, induced transcription, induced; signaling pathway regulation 30100205 1 23 278 induces K63-linked polyubiquitination of RIG-I +Pik3r1 PIK3R1 KINASE; Kinase, lipid; Motility/polarity/chemotaxis P26450 18708 13 D1|13 53.92 cM mouse Y467-p 451144 SREYDRLyEEYTRTS PI3K_P85_iSH2 cell cycle regulation; carcinogenesis, induced; cell motility, induced; cell growth, induced; apoptosis, inhibited 36310322 14 52 2216 +ADRB1 ADRB1 GPCR, family 1; Membrane protein, integral; Membrane protein, multi-pass; Receptor, GPCR P08588 153 10q25.3 human S462-p 89117904 AAADSDSsLDEPCRP receptor internalization, induced; molecular association, regulation; intracellular localization ARRB1(INDUCES) 28472170 2 3 0 beta-arrestin recruitment to the ADRB1 +Eif3f eIF3-epsilon EC 3.4.19.12; Translation; Translation initiation Q9DCH4 66085 7|7 E3 mouse K321-ub 7388007 SLVNQVPkIVPDDFE MitMem_reg protein degradation 19073596 1 0 0 regulates skeletal muscle atrophy +TFE3 TFE3 DNA-binding; Oncoprotein; Transcription factor P19532 7030 Xp11.23 human S246-p 56653430 PTGSAPNsPMALLTI MITF_TFEB_C_3_N intracellular localization 32662822 1 2 0 +Psma3 PSMA3 EC 3.4.25.1; Protease; Proteasome complex P18422 29670 6q24 rat S250-p 451185 SLKEEDEsDDDNM__ protein stabilization 14583091 2 105 818 +ARFGEF1 ARFGEF1 GEF; GEF, ARF; Nucleolus Q9Y6D6 10565 8q13.2 human S883-p 459627 EIAGKKIsMKETKEL intracellular localization 16467138 1 0 0 +ECT2 ECT2 iso2 GEF; GEF, Rac/Rho; Motility/polarity/chemotaxis Q9H8V3-2 1894 3q26.31 human T790-p 1412327900 NTKDMDStLSRASRA intracellular localization 30542068 1 0 0 correlates with cytoplasmic localization +DDX5 DDX5 EC 3.6.4.13; Helicase; Nuclear receptor co-regulator; Nucleolus; RNA splicing; RNA-binding; Spliceosome P17844 1655 17q23.3 human S198-p 27807802 CRACRLKsTCIYGGA DEAD molecular association, regulation; intracellular localization cell growth, inhibited DROSHA(INDUCES) 23482664 1 1 0 micro-RNA processing, c-Myc abundance reduced +RAF1 RAF1 EC 2.7.11.1; KINASE; Kinase, protein; Oncoprotein; Protein kinase, Ser/Thr (non-receptor); Protein kinase, TKL P04049 5894 3p25.2 human Y340-p 447749 RGQRDSSyYWEIEAS molecular association, regulation; enzymatic activity, inhibited; phosphorylation; enzymatic activity, induced RAF1(DISRUPTS) 10998357; 11259591; 11274179; 12551923; 17998336; 18775988; 19595761; 7692235; 9689060 29 1 1 +NFATC3 NFAT4 DNA-binding; Transcription factor Q12968 4775 16q22.1 human S215-p 11507604 PLTSPGGsPGGCPGE intracellular localization 9630228 1 0 0 cytoplasmic localization (inhibition of nuclear localization) +CASP8 CASP8 Apoptosis; EC 3.4.22.61; Protease Q14790 841 2q33.1 human T273-p 56640300 DAGALTTtFEELHFE Peptidase_C14 enzymatic activity, induced 27325299 4 0 0 +TAB1 TAB1 Activator; Motility/polarity/chemotaxis Q15750 10454 22q13.1 human K335-ub 1881312005 QAVVDRVkRIHSDTF signaling pathway regulation 34017102 1 0 0 TRIM26 enhances TLRs-induced NF-kB and MAPK signaling. +Idh2 IDH2 Carbohydrate Metabolism - citrate (TCA) cycle; EC 1.1.1.42; Mitochondrial; Other Amino Acids Metabolism - glutathione; Oxidoreductase P54071 269951 7 D2|7 45.43 cM mouse K256-ac 11320276 STKNTILkAYDGRFK Iso_dh protein stabilization; enzymatic activity, inhibited; protein conformation 28852116 1 4 0 K256Q mutant had lower activity than WT-pocket size decreased +CCNT1 CCNT1 Cell cycle regulation; Transcription initiation complex O60563 904 12q13.11-q13.12 human K390-ac 11322420 PSAKVSLkEYRAKHA molecular association, regulation; enzymatic activity, induced transcription, induced BCDIN3(DISRUPTS); HEXIM1(DISRUPTS); BRD4(INDUCES) RNA(DISRUPTS) 19387490; 19828451; 22084242 3 2 0 enhances CDK9/cyclin T1 transcriptional activity, disrupting HEXIM1 and BCDIN3 association; Interaction with BRD4 disrupts interaction with HEXIM1 and 7SK snRNA +CCNA2 CCNA2 Cell cycle regulation; Nuclear receptor co-regulator P20248 890 4q27 human K91-ub 1878249906 HVTVPPWkANSKQPA protein degradation cell cycle regulation 31413110 1 0 0 +Eif2b5 eIF2B-epsilon Translation; Translation initiation Q64350 192234 11q23 rat S713-p 449908 REAEEESsDDD____ W2 molecular association, regulation eIF2-alpha(INDUCES) 11500362 3 9 2 +Dynlt1 DYNLT1 Microtubule-binding; Motility/polarity/chemotaxis; Motor Q9Z336 83462 1q11 rat T94-p 456225 SSTDGSCtVRWENKT Tctex-1 molecular association, regulation 15992542 7 0 0 +F2RL1 F2RL1 GPCR, family 1; Membrane protein, integral; Membrane protein, multi-pass; Receptor, GPCR P55085 2150 5q13.3 human S387-p 15426050 SRKSSSYsSSSTTVK receptor desensitization, induced; molecular association, regulation; phosphorylation signaling pathway regulation ARRB1(INDUCES); ARRB2(INDUCES) 33073187 1 2 1 inhibits ERK phosphorylation and signaling; regulates calcium signaling +Gprc5b GPRC5B GPCR, family 3; Membrane protein, integral; Membrane protein, multi-pass; Receptor, GPCR Q923Z0 64297 7|7 F2 mouse Y330-p 3972629 EMHLPRAyMENKAFS molecular association, regulation Fyn(INDUCES) 23169819 1 2 1 induces phosphorylation of Cav1 and inflammatory signaling in adipose tissue +SMN1 SMN RNA processing; RNA-binding Q16637 6606 5q13.2 human T85-p 20503415 NKSQKKNtAASLQQW SMN molecular association, regulation; intracellular localization SIP1(DISRUPTS); coilin(INDUCES); GEMIN8(DISRUPTS) 21609790; 24602413 2 5 0 +Tdg TDG DNA repair, damage; EC 3.2.2.29; Hydrolase; Nuclear receptor co-regulator P56581 21665 10 C1|10 39.72 cM mouse K95-ac 458995 KKPATSKkSGKSTKS molecular association, regulation; acetylation; phosphorylation DNA repair, induced; chromatin organization, altered; DNA repair, inhibited; transcription, induced APE1(DISRUPTS) DNA(DISRUPTS) 11864601; 19966277 2 1 1 inhibits phosphorylation at other sites; histone acetylation +Ets1 Ets-1 DNA-binding; Motility/polarity/chemotaxis; Oncoprotein; Transcription factor P27577 23871 9 A4|9 17.97 cM mouse T38-p 447950 CADVPLLtPSSKEMM protein conformation transcription, induced CBP(INDUCES) 11948414; 20534573; 28716922 14 4 5 +MAFA MAFA DNA-binding; Oncoprotein; Transcription factor; Tumor suppressor Q8NHW3 389692 8q24.3 human T134-p 456029 NPEALNLtPEDAVEA Maf_N protein degradation signaling pathway regulation 19407223; 23660596 4 2 0 Ubiquitin proteosomal pathway +PDGFRA PDGFRA EC 2.7.10.1; KINASE; Kinase, protein; Membrane protein, integral; Oncoprotein; Protein kinase, TK; Protein kinase, tyrosine (receptor) P16234 5156 4q12 human Y762-p 448440 SDIQRSLyDRPASYK PK_Tyr_Ser-Thr molecular association, regulation; phosphorylation; enzymatic activity, induced signaling pathway regulation CRKL(INDUCES); CDK6(INDUCES) 33626330; 9546424 4 13 321 induces AKT phosphorylation and signaling +MACF1 ACF7 Actin-binding; Cytoskeletal; Motility/polarity/chemotaxis Q9UPN3 23499 1p34.3 human S7326-p 18507011 RAGSRASsRRGSDAS intracellular localization cell motility, induced; cytoskeletal reorganization 21295697 1 2 3 inhibits localization along microtubules, alters organization of microtubules, regulates skin wound repair, SC migration +Akt1 Akt1 EC 2.7.11.1; KINASE; Kinase, protein; Oncoprotein; Protein kinase, AGC; Protein kinase, Ser/Thr (non-receptor) P31750 11651 12 F1|12 61.2 cM mouse T450-p 447857 TAQMITItPPDQDDS Pkinase_C ubiquitination translation, altered 21045808 30 5 1 prevents cotranslational Akt ubiquitination +Ctnnd1 CTNND1 Actin-binding; Adaptor/scaffold; Cell adhesion; G protein regulator, misc.; Motility/polarity/chemotaxis D3ZZZ9 311163 3q24 rat T310-p 450457 GTARRTGtPSDPRRR intracellular localization; activity, inhibited cell motility, induced CDH2(DISRUPTS) 24929360 10 7 28 +BCAR1 P130Cas Adaptor/scaffold; Motility/polarity/chemotaxis P56945 9564 16q23.1 human Y306-p 448779 PSNHHAVyDVPPSVS cell growth, induced 26867768 3 15 191 metastases +H3c1 H3 DNA-binding P68433 360198 13|13 A3.1 mouse K18-ac 465520 TGGKAPRkQLATKAA Histone methylation endocytosis, altered; cell adhesion, altered 17882261; 33195484 57 27 381 axon guidance; K18 enhances methylation at H3R17me2 +Ptpn11 SHP-2 EC 3.1.3.48; Motility/polarity/chemotaxis; PHOSPHATASE; Protein phosphatase, tyrosine (non-receptor) P35235 19247 5|5 F mouse Y63-p 455054 IQNTGDYyDLYGGEK SH2 enzymatic activity, inhibited; phosphorylation cell growth, altered 18827006 1 13 72 +NUTM1 NUTM1 Unknown function Q86Y26 256646 15q14 human S1029-p 13165102 YLLASKLsLSPREHP NUT intracellular localization 17934517 1 0 0 nuclear-cytoplasmic shuttling +Axin1 axin 1 Adaptor/scaffold; Tumor suppressor O70239 79257 10q12 rat S492-p 451104 SPGPGHRsPDSGHVA Axin_b-cat_bind cytoskeletal reorganization 22933777 2 12 6 Phosphorylation regulates responsive to Sema3A induced growth cone collapse. +TSPYL2 TSPYL2 DNA replication; Transcription regulation Q9H2G4 64061 Xp11.22 human S20-p 3212187 RRLSSSEsPQRDPPP cell growth, altered 11395479 1 6 7 +TRAIP TRAIP EC 6.3.2.-; Ligase; Nucleolus; UBIQUITIN LIGASE; Ubiquitin conjugating system; Ubiquitin ligase Q9BWF2 10293 3p21.31 human K205-sm 53529103 AVYCVSLkKEYENLK protein degradation; molecular association, regulation; protein stabilization; ubiquitination; intracellular localization cell cycle regulation 26820530; 30619364 2 0 0 interacts with nsp1-alpha of PRRSV (porcine reproductive and respiratory syndrome virus) K48 ubiquitination and degradation of serine/threonine-protein kinase (TBK1); inhibits ubiquitination +ATXN3 ataxin-3 DEUBIQUITINASE; DNA repair, damage; EC 3.4.19.12; Protease; Transcription regulation; Ubiquitin-specific protease P54252 4287 14q32.12 human K117-ub 10835606 RSFICNYkEHWFTVR Josephin enzymatic activity, induced 25988170 3 12 90 induces deubiquitinase activity of the enzyme +Ezr Ezrin Cytoskeletal; Motility/polarity/chemotaxis P26040 22350 17|17 A1 mouse Y354-p 448105 LMLRLQDyEQKTKRA ERM_helical intracellular localization apoptosis, inhibited; cell growth, altered 18182570; 24385580 14 5 259 +SNAP29 SNAP29 Vesicle O95721 9342 22q11.21 human S105-p 56651951 MDQDLKIsQKHINSI V-SNARE_C intracellular localization; receptor recycling, altered cell adhesion, induced 29454964 1 1 0 focal adhesion structure formation; membrane localization and for membrane fusion dependent processes +PRKDC DNAPK DNA repair, damage; EC 2.7.11.1; KINASE; Kinase, protein; Nucleolus; Protein kinase, Ser/Thr (non-receptor); Protein kinase, atypical P78527 5591 8q11.21 human S2053-p 23099445 STGVQSYsYSSQDPR DNAPKcs_CC3 molecular association, regulation DNA repair, inhibited DNA(INDUCES) 24687855 1 0 2 induces c-NHEJ, restricts end processing +SARS1 SARS Aminoacyl-tRNA synthetase; EC 6.1.1.11; Ligase; RNA processing; Translation; Translation regulation P49591 6301 1p13.3 human K323-ac 11317592 FRVHQFEkIEQFVYS tRNA-synt_2b intracellular localization carcinogenesis, inhibited; cell growth, inhibited 34400610 1 2 0 nuclear translocation, enhances adipose deposition in mice, inhibits progression of breast cancer, and the growth of breast cancer xenografts in mice +HSPA5 GRP78 Chaperone; Heat shock protein; KINASE P11021 3309 9q33.3 human K585-ac 466070 DKEKLGGkLSSEDKE HSP70 molecular association, regulation PERK(DISRUPTS) 20072656 1 2 5 participates verinostat-induced cytotoxicity leading to its antitumor activity +KLRF1 KLRF1 Membrane protein, integral; Receptor, misc. Q9NZS2 51348 12p13.31 human Y7-p 17831300 _MQDEERyMTLNVQS molecular association, regulation Syk(INDUCES); Lck(INDUCES); ZAP70(INDUCES) 21149606 1 0 0 required for KLRF1-mediated cytotoxicity +ZNF322 ZNF322A C2H2-type zinc finger protein; Transcription factor Q6U7Q0 79692 6p22.2 human T150-p 1869121002 LVHQRSHtGEKPYLC activity, induced; molecular association, regulation carcinogenesis, induced; chromatin organization, altered; cell motility, induced; cell growth, induced; transcription, induced DNA(INDUCES) 31399647 1 1 0 chromatin binding; increases recruitment to ADD1 and CCND1 promoters +BATF BATF DNA-binding; Transcription factor Q16520 10538 14q24.3 human S43-p 450321 NRIAAQKsRQRQTQK bZIP_1 transcription, inhibited 12809553 1 0 0 +CYP3A4 CYP3A4 Cell surface; Cofactor and Vitamin Metabolism - retinol; EC 1.14.14.1; Lipid Metabolism - linoleic acid; Membrane protein, integral; Oxidoreductase; Xenobiotic Metabolism - drug metabolism - cytochrome P450; Xenobiotic Metabolism - drug metabolism - other enzymes; Xenobiotic Metabolism - metabolism by cytochrome P450 P08684 1576 7q22.1 human S420-p 5938007 KFLPERFsKKNKDNI p450 protein degradation; ubiquitination 19095658; 22101235; 25451919 3 2 0 +PCBP2 hnRNP E2 RNA splicing; RNA-binding Q15366 5094 12q13.13 human S173-p 482916 MLETLSQsPPKGVTI protein stabilization; molecular association, regulation cell differentiation, inhibited; translation, inhibited RNA(INDUCES) 17475908 1 19 2 +FBXW5 FBXW5 UBIQUITIN LIGASE; Ubiquitin conjugating system; Ubiquitin ligase Q969U6 54461 9q34.3 human S151-p 20831310 SQFNKDDsLLLASGV protein degradation; ubiquitination cell cycle regulation 21725316 1 0 0 Induces degradation of HsSAS-6 and inhibits its ubiquitination. Induces centrosome duplication +PRKCA PKCA EC 2.7.11.13; KINASE; Kinase, protein; Oncoprotein; Protein kinase, AGC; Protein kinase, Ser/Thr (non-receptor) P04409 282001 cow T495-p 449890 HMMDGVTtRTFCGTP Pkinase enzymatic activity, induced 8349635 2 1 11 +Rgs14 RGS14 GAP; GAP, RGS O08773 114705 17p14 rat S218-p 4713256 PKLKPGKsLPLGVEE molecular association, regulation 14-3-3 gamma(INDUCES); G-alpha i1(DISRUPTS) 30093406 1 18 1 Protein 14-3-3- gamma decreased binding G-alpha-i1:AlF binding with RGS14 in RGS domain +E2F6 E2F6 DNA-binding; Transcription factor O75461 1876 2p25.1 human S12-p 27532759 RPARKLPsLLLDPTE molecular association, regulation transcription, induced DNA(DISRUPTS) 23954429 1 5 0 response to DNA replication stress +Hsf1 HSF1 DNA-binding; Transcription factor P38532 15499 15 D3|15 35.95 cM mouse S230-p 448072 PKYGRQYsLEHVHGP transcription, induced 23055521 16 2 4 +SNRPB snRNP B1 RNA processing; RNA splicing; RNA-binding; Spliceosome P14678 6628 20p13 human R172-m2 476757 PTQYPPGrGGPPPPM molecular association, regulation SMN(INDUCES) 11720283 1 1 4 +Ncl NCL DNA-binding; Helicase; Nuclear receptor co-regulator; Nucleolus; RNA-binding P09405 17975 1 C5|1 43.94 cM mouse S40-p 468243 MSEDEDDsSGEEEVV molecular association, regulation carcinogenesis, induced; cell growth, induced; transcription, induced RNA(INDUCES) 37039106 1 18 2 +Fbp1 FBPase Carbohydrate Metabolism - fructose and mannose; Carbohydrate Metabolism - glycolysis and gluconeogenesis; Carbohydrate Metabolism - pentose phosphate pathway; EC 3.1.3.11; Mitochondrial; Phosphatase (non-protein) Q9QXD6 14121 13|13 B3 mouse S144-p 15501075 FGIYRKKsTDEPSEK FBPase molecular association, regulation carcinogenesis, induced; cell motility, induced; cell growth, induced; transcription, induced; signaling pathway regulation CHIP(DISRUPTS); NFkB-p65(DISRUPTS) 32754266 1 4 3 induces NFKB binding to DNA, regulates NFKB pathway +NR0B2 NR0B2 Nuclear receptor; Nuclear receptor co-regulator; Transcription, coactivator/corepressor Q15466 8431 1p36.11 human T55-p 28702400 QLCAPHRtCREALDV Hormone_recep molecular association, regulation; methylation; intracellular localization chromatin organization, altered; transcription, inhibited; signaling pathway regulation HNF4 alpha(INDUCES); PGC-1 alpha(INDUCES); PRMT5(INDUCES); NR5A2(NOT_REPORTED); BRME1(INDUCES) DNA(INDUCES) 23824184 4 0 0 increases methylation NR0B2 at R57 +Irs1 IRS1 Adaptor/scaffold; Motility/polarity/chemotaxis P35570 25467 9q34 rat Y608-p 447555 NLHTDDGyMPMSPGV molecular association, regulation PIK3R1(INDUCES) 7504175; 7588273 33 12 294 +Polr2a POLR2A EC 2.7.7.48; EC 2.7.7.6; Nucleotide Metabolism - purine; Nucleotide Metabolism - pyrimidine; Transcription initiation complex; Transferase P08775 20020 11 B3|11 42.86 cM mouse K1922-ub 2134719 TYSPTSPkYSPTSPT RNA_pol_Rpb1_R protein degradation 17526739 1 1 0 +MVD MVD EC 4.1.1.33; Lyase; Secondary Metabolites Metabolism - terpenoid backbone biosynthesis P53602 4597 16q24.2 human S96-p 476192 LARKRRNsRDGDPLP activity, induced apoptosis, inhibited 25378391 1 21 8 Rac1 activation/geranylgeranylation, disruption of the mevalonate pathway induces macrophage apoptosis. +SORBS2 ArgBP2 Adaptor/scaffold; Motility/polarity/chemotaxis O94875 8470 4q35.1 human S259-p 467482 DFRKRRKsEPAVGPP molecular association, regulation; intracellular localization cytoskeletal reorganization 14-3-3 zeta(INDUCES); ACTN1(DISRUPTS) 25429109 1 38 24 ArgBP2 is down-regulated in some aggressively metastatic cancers +AHR AHR DNA-binding; Transcription factor P35869 196 7p21.1 human S68-p 451013 INKLDKLsVLRLSVS HLH intracellular localization 14985336 1 0 0 +MPL MPL Membrane protein, integral; Receptor, cytokine P40238 4352 1p34.2 human K573-ub 11956705 SLLEILPkSSERTPL protein degradation cell growth, inhibited 19880496 1 0 0 +FH fumarase Carbohydrate Metabolism - citrate (TCA) cycle; EC 4.2.1.2; Lyase; Mitochondrial; Tumor suppressor P07954 2271 1q43 human S46-p 36132325 PNAARMAsQNSFRIE molecular association, regulation; intracellular localization carcinogenesis, induced; cell growth, induced; signaling pathway regulation RBPJ(DISRUPTS); 14-3-3 zeta(INDUCES) 30683654 1 5 0 +Csnk1g2 CK1G2 EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, CK1; Protein kinase, Ser/Thr (non-receptor) Q8BVP5 103236 10|10 C1 mouse S211-p 1871246000 IPYREHKsLTGTARY Pkinase molecular association, regulation; phosphorylation RIPK3(INDUCES) 33206046 1 1 0 inhibits phosphorylation of MLKL, binding to RIPK3 inhibits RIPK3 binding to RIPK1 +Megf10 MEGF10 Membrane protein, integral Q6DIB5 70417 18|18 D3 mouse Y1061-p 478426 PARRDSPyAEINNST cell cycle regulation; cell motility, altered 18515860 1 3 7 +APH1A APH1A Apoptosis; Endoplasmic reticulum; Membrane protein, integral; Membrane protein, multi-pass Q96BI3 51107 1q21.2 human S257-p 15229310 DSRVMVYsALRIPPE molecular association, regulation; enzymatic activity, altered ARRB2(INDUCES) 35858570 1 5 16 +Wwtr1 TAZ Oncoprotein; Transcription, coactivator/corepressor Q9EPK5 97064 3|3 D mouse Y316-p 27138200 SGLGLGCySVPTTPE molecular association, regulation; intracellular localization cell growth, induced; transcription, induced; transcription, inhibited TAZ(INDUCES) 23045390; 28939028 3 0 0 nuclear localization; Y316 TAZ negatively regulates SL6A12 and SLC5A3 gene expression; luciferase reporter +PITPNM1 PITPNM1 Cell surface O00562 9600 11q13.2 human T59-p 3597300 PGGSGQYtHKVYHVG IP_trans intracellular localization 12225667 1 0 0 +Pcyt1a PCYT1A EC 2.7.7.15; Lipid Metabolism - glycerophospholipid; Transferase P19836 140544 11q22 rat S315-p 451321 GRMLQAIsPKQSPSS enzymatic activity, inhibited 15788406 4 67 13 +Mybl2 B-Myb DNA-binding; Motility/polarity/chemotaxis; Transcription factor P48972 17865 2 H2|2 84.0 cM mouse T497-p 450109 TPLHRDKtPLHQKYP Cmyb_C activity, induced 9840932 4 0 12 +Mpl MPL Membrane protein, integral; Receptor, cytokine Q08351 17480 4 D2.1|4 54.61 cM mouse S565-p 3091404 LLEILPKsSESTPLP activity, induced; phosphorylation cell growth, altered 10918061 1 0 0 tyrosine phosphorylation of JAK2 +TIGIT TIGIT Cell surface; Membrane protein, integral Q495A1 201633 3q13.31 human Y225-p 27266400 DCAELHDyFNVLSYR molecular association, regulation signaling pathway regulation GRB2(INDUCES); SHIP(INDUCES) 23154388 2 0 0 Grb2 enhances SHIP1 binding to TIGIT; inhibits NK cell activity by suppressing PI3K and MAPK signaling +Grb10 GRB10 Adaptor/scaffold Q60760 14783 11 A1|11 7.15 cM mouse S503-p 455870 MNILSSQsPLHPSTL molecular association, regulation; protein stabilization cell growth, inhibited; transcription, induced; signaling pathway regulation INSR(DISRUPTS); Raptor(INDUCES) 21659605; 24746805; 26000738 7 16 17 reduced soft agar colony formation ; thermogenic and lipolytic gene expression induced +Ppp1r12a MYPT1 Motility/polarity/chemotaxis; PHOSPHATASE; Protein phosphatase, regulatory subunit Q10728 116670 7q21 rat T697-p 448587 ARQSRRStQGVTLTD enzymatic activity, inhibited; activity, inhibited; phosphorylation 12359219; 19095646; 33972751 66 42 226 inhibits MLCP activity +Klf4 KLF4 C2H2-type zinc finger protein; DNA-binding; Transcription factor Q923V7 114505 5q24 rat K224-ac 1880848202 PGGGLMGkFVLKASL transcription, induced 35046941 2 0 0 IL-6 transcription +LYN LYN EC 2.7.10.2; KINASE; Kinase, protein; Oncoprotein; Protein kinase, TK; Protein kinase, tyrosine (non-receptor) P07948 4067 8q12.1 human Y32-p 454717 RNTERTIyVRDPTSN phosphorylation carcinogenesis, induced; cell growth, induced 23764002 1 12 105 induces phosphorylation at Y397 MCM7 phosphorylation +IL6ST gp130 Membrane protein, integral; Receptor, cytokine P40189 3572 5q11.2 human Y759-p 448181 NTSSTVQySTVVHSG activity, induced; molecular association, regulation; activity, inhibited; phosphorylation cell differentiation, altered; signaling pathway regulation; transcription, altered SOCS3(INDUCES); SHP-2(INDUCES) 10661409; 10764798; 10777583; 10800945; 10829066; 10946280; 16459330; 25078695; 9632795 14 1 2 induces ERK phosphorylation and signaling; Mutation of gp130 Y759F removes transcriptional inhibition (through removing SOCS3 binding site). SOCS3's effect through OSMR is tyrosine phosphorylation-independent. +ATP1A1 ATP1A1 EC 3.6.3.9; Hydrolase; Membrane protein, integral; Membrane protein, multi-pass; Transporter; Transporter, ion channel P05023 476 1p13.1 human Y260-p 454981 TARGIVVyTGDRTVM E1-E2_ATPase molecular association, regulation; phosphorylation carcinogenesis, inhibited; transcription, inhibited; signaling pathway regulation Src(INDUCES) 30120256 2 44 1345 regulates phosphorylation of ERK, Src, Akt, EGFR, controls aerobic glycolysis +Pea15 PEA-15 Apoptosis; Motility/polarity/chemotaxis Q9Z297 100736554 hamster S104-p 455750 TKLTRIPsAKKYKDI molecular association, regulation ERK1(DISRUPTS); ERK2(DISRUPTS) 15916534 13 27 322 +PTK2B Pyk2 EC 2.7.10.2; KINASE; Kinase, protein; Nuclear receptor co-regulator; Protein kinase, TK; Protein kinase, tyrosine (non-receptor) Q14289 2185 8p21.2 human S778-p 2192705 HNVFKRHsMREEDFI intracellular localization 22802128 1 10 2 +Traf6 TRAF6 EC 6.3.2.-; Ligase; UBIQUITIN LIGASE; Ubiquitin conjugating system; Ubiquitin ligase P70196 22034 2|2 E2 mouse S46-p 1040254704 SASTGNLsSSFMEEI ubiquitination 29563609 1 0 0 colon epithelia in?ammation +CXADR CXADR Cell adhesion; Membrane protein, integral; Receptor, misc. P78310 1525 21q21.1 human S293-p 3193535 SRTSTARsYIGSNHS molecular association, regulation; intracellular localization KIF22(INDUCES) 29382784 1 5 2 translocation within cell junctions in response to EGF +KCNJ2 KCNJ2 Channel, potassium; Membrane protein, integral; Membrane protein, multi-pass P63252 3759 17q24.3 human Y242-p 2097300 RITSEGEyIPLDQID IRK_C activity, induced; activity, inhibited cell differentiation, altered 18216177; 21570948 3 0 0 inactivates KCNJ2 current +Marcksl1 MLP Cell cycle regulation P28667 17357 4 D2.2|4 63.26 cM mouse T148-p 454299 QEGKAAAtPESQEPQ MARCKS protein conformation cytoskeletal reorganization; cell motility, inhibited 22751924 1 44 53 Increases actin stability and regulation of dendritic filopodium generation in neurons +GJA1 GJA1 Channel, misc.; Membrane protein, integral; Membrane protein, multi-pass; Motility/polarity/chemotaxis P17302 2697 6q22.31 human S282-p 448854 TAPLSPMsPPGYKLV protein degradation; protein stabilization; molecular association, regulation; ubiquitination; intracellular localization; activity, inhibited; protein conformation endocytosis, induced; carcinogenesis, inhibited; apoptosis, induced; cytoskeletal reorganization; signaling pathway regulation CLTA(INDUCES) 15958277; 18047584; 23828237; 24399133; 24492000; 24742583; 26033246; 33255329 42 7 1 gap junction regulation; inhibits pregnancy-adapted Ca2+ response +TH TH Amino Acid Metabolism - tyrosine; EC 1.14.16.2; Endoplasmic reticulum; Mitochondrial; Oxidoreductase; Vesicle P07101 7054 11p15.5 human S71-p 448545 RFIGRRQsLIEDARK TOH_N enzymatic activity, induced 7901013 62 11 11 +ENG ENG Membrane protein, integral; Motility/polarity/chemotaxis; Receptor, misc. P17813 2022 9q34.11 human Y614-p 34729907 TAALWYIySHTRSPS receptor internalization, induced; protein degradation; intracellular localization cell motility, induced; cell growth, induced 25070888 1 0 0 1)ALK1, TBRII, ENG degradation 2) induces endothelial capillary sprouting and stability, EC functions during angiogenesis +Sln sarcolipin Endoplasmic reticulum; Membrane protein, integral Q6SLE7 rat T5-p 459214 ___MERStQELFINF Sarcolipin activity, induced 19631655 6 0 0 regulates myocyte calcium transient and contractility +Cldn4 Claudin-4 Cytoskeletal; Membrane protein, integral; Membrane protein, multi-pass Q5XIT8 304407 rat S199-p 15425616 KPYSAKYsAARSVPA molecular association, regulation; intracellular localization occludin(INDUCES) 25503106 1 1 2 increased paracellular peremability and saliva secretion, crucial component of tight juction barrier +MFN2 MFN2 Cell cycle regulation; Cytoskeletal; EC 3.6.5.-; Hydrolase; Membrane protein, integral; Membrane protein, multi-pass; Mitochondrial O95140 9927 1p36.22 human T111-p 17402150 RTSNGKStVINAMLW Dynamin_N intracellular localization autophagy, induced 35646911 3 1 0 regulates Parkin recruitmeent to mitochondria; miophagy +NOP53 GLTSCR2 Nucleolus Q9NZM5 29997 19q13.33 human T289-p 60120300 PATEQAAtQESTFQE Nop53 protein degradation; molecular association, regulation; intracellular localization apoptosis, induced RPL11(DISRUPTS) 27829214 1 0 0 +Cryab CRYAB Chaperone; Heat shock protein P23927 12955 9 A5.3|9 27.75 cM mouse S59-p 448783 PSFLRAPsWIDTGLS protein degradation; molecular association, regulation; intracellular localization apoptosis, inhibited; cytoskeletal reorganization; signaling pathway regulation 10816593; 16979163; 19252088; 28196893; 29088822 46 22 0 stabilizes actin filaments; phosphorylation of this site stimulates interaction with multiple proteins and activates multiple pathways; induces reactive astrogliosis +VPS13D VPS13D Vesicle Q5THJ4 55187 1p36.22-p36.21 human T770-p 1872786900 FSDDEYKtPLATPPN VPS13_mid_rpt molecular association, regulation; intracellular localization VAPB(INDUCES) 33891013 1 0 0 +CCNB1 CCNB1 Activator; Cell cycle regulation P14635 891 5q13.2 human S128-p 448815 LVDTASPsPMETSGC intracellular localization DNA(INDUCES) 20117088; 22726437 5 1 0 enhances nuclear import +MEF2C MEF2C DNA-binding; Transcription factor Q06413 4208 5q14.3 human T80-p 19083402 NEPHESRtNSDIVET molecular association, regulation cell differentiation, induced p300(INDUCES) 21556048 1 1 0 skeletal, but not cardiac, myogenesis, induces recruitment of p300 to muscle-specific promoters for histone acetylation +Tnni3 TNNI3 Actin-binding; Motility/polarity/chemotaxis; Motor P23693 29248 1q12 rat S24-p 448424 APVRRRSsANYRAYA Troponin-I_N protein conformation; activity, inhibited cell motility, altered; cytoskeletal reorganization 16236710; 16936010; 18550549; 28587770 64 12 16 heart contractility and relaxation; regulates cardiac contractile function +UBA52-RPS27A-UBB-UBC ubiquitin Ubiquitin-like modifier P62991 mouse K11-ub 486301 FVKTLTGkTITLEVE ubiquitin protein degradation; molecular association, regulation GDI1(DISRUPTS) 33976225; 35343654 25 22 155 Promotes the Post-Golgi Tra?cking of TLR4 and TLR9; inhibit the post-ER tra?cking of TLRs; forms an electrostatic interaction with D129, loss of K133 ubiquitylation or the K133:D129 salt bridge stabilizes IL-1B +CEACAM1 CEACAM1 Cell adhesion; Immunoglobulin superfamily; Membrane protein, integral; Motility/polarity/chemotaxis P13688 634 19q13.2 human S494-p 473039 KMNEVTYsTLNFEAQ apoptosis, altered; cytoskeletal reorganization 17192268 1 0 0 plays a role in cell polarization and lumen formation +NPM1 NPM1 Nucleolus; Oncoprotein; RNA-binding; Translation P06748 4869 5q35.1 human S48-p 14577038 QLSLRTVsLGAGAKD Nucleoplasmin protein degradation; molecular association, regulation; intracellular localization; enzymatic activity, inhibited; protein conformation signaling pathway regulation NPM1(NOT_REPORTED) 25071014 2 3 0 regulates NPM1 oligomerization; induces cellular resistance to IR; inhibits MDM2 activity; induces p53 stability; regulates ARF localization and stability +KHSRP KHSRP RNA-binding Q92945 8570 19p13.3 human S193-p 473552 GLPERSVsLTGAPES KH_1 molecular association, regulation; intracellular localization; protein conformation transcription, altered 14-3-3 sigma(INDUCES); 14-3-3 zeta(INDUCES) 17177604; 19198587 2 10 7 controls beta-catenin gene expression by controlling its mRNA stability; phosphorylation of this site inhibits interaction with the exosome +ARHGEF7 ARHGEF7 iso1 GEF; GEF, Rac/Rho; Motility/polarity/chemotaxis Q14155-1 8874 13q34 human T526-p 455216 EFASRKStAALEEDA RhoGEF67_u2 activity, induced; molecular association, regulation cell motility, altered; cytoskeletal reorganization ARHGAP13(DISRUPTS) 14557270; 25150978 7 6 1 +RAD17 RAD17 Cell cycle regulation O75943 5884 5q13.2 human S656-p 447756 SASELPAsQPQPFSA protein stabilization; molecular association, regulation; phosphorylation cell cycle regulation; cell growth, altered RAD1(INDUCES); claspin(INDUCES) 11418864; 11687627; 16885023; 24876101; 26960975 13 0 0 +LIFR LIFR Membrane protein, integral; Receptor, cytokine P42702 3977 5p13.1 human K620-ac 1883810405 VGSSPPSkIASMEIP molecular association, regulation; phosphorylation carcinogenesis, induced; cell growth, induced LIFR(INDUCES) 35172032 1 1 0 necessary for homodimerization and subsequent S1044 phosphorylation, and consequent AKT activation, and PCa progression, promoted the growth and metastasis of PCa cells +ZFPM1 FOG1 C2H2-type zinc finger protein; Transcription regulation Q8IX07 161882 16q24.2 human K501-sm 14988611 SPAPARVkAELSSPT molecular association, regulation CTBP1(INDUCES) 20587419 1 0 0 +VIM Vimentin Cytoskeletal; Motility/polarity/chemotaxis P08670 7431 10p13 human S339-p 14582709 ALKGTNEsLERQMRE Filament molecular association, regulation; intracellular localization carcinogenesis, induced; cell motility, induced; cell growth, induced; transcription, induced SMAD2(INDUCES); SMAD3(INDUCES) 33963314 1 20 0 +Pld1 PLD1 iso2 EC 3.1.4.4; Lipid Metabolism - ether lipid; Lipid Metabolism - glycerophospholipid; Motility/polarity/chemotaxis; Phospholipase P70496-2 25096 2q24 rat T147-p 448573 PIPTKRHtFRRQNVK PX enzymatic activity, induced 10441128; 10788479 5 0 0 +Ncoa3 SRC-3 ACETYLTRANSFERASE; Acetyltransferase; EC 2.3.1.48; Motility/polarity/chemotaxis; Nuclear receptor co-regulator; Transcription, coactivator/corepressor O09000 17979 2|2 H3 mouse R1184-m2 2363403 LRMQLQQrLQGQQFL protein degradation transcription, inhibited CBP(INDUCES) 17043108 1 1 21 +TIAM1 TIAM1 GEF; GEF, Rac/Rho; Motility/polarity/chemotaxis; Oncoprotein Q13009 7074 21q22.11 human S1466-p 4727743 SDAVSASsPEKESQQ phosphorylation cell cycle regulation 26078008 1 8 0 induces phosphorylation and centrosomal activation of PAK1/2 in mitosis; regulates centrosome separation +Tab2 TAB2 Adaptor/scaffold Q99K90 68652 10|10 A1 mouse K329-sm 31089526 RKNQIEIkLEPPQRN molecular association, regulation transcription, inhibited; signaling pathway regulation 33184450 2 0 0 inhibition of TRAF6/TAB2/TAK1 complex and downstream MAPK and NF-?B pathway +H4C1 H4 DNA-binding P62805 8359 6p22.2 human K16-ac 458960 GLGKGGAkRHRKVLR protein stabilization; acetylation; molecular association, regulation; intracellular localization; methylation cell cycle regulation; carcinogenesis, induced; carcinogenesis, inhibited; cell growth, inhibited; apoptosis, induced; transcription, induced; signaling pathway regulation; transcription, altered; DNA repair, induced; chromatin organization, altered; cell growth, induced; cell differentiation, induced; DNA repair, altered; cytoskeletal reorganization TBN(INDUCES); polybromo 1(INDUCES); 14-3-3 zeta(INDUCES); 14-3-3 epsilon(INDUCES); CGI-09(INDUCES); 53BP1(DISRUPTS); MYST1(INDUCES); BRD4(INDUCES); BRDT(INDUCES); BRD7(INDUCES); H2AZ(INDUCES); BRD4(NOT_REPORTED); H2AFV(INDUCES); PUS1(INDUCES); THOC4(INDUCES); TAF4(INDUCES) DNA(DISRUPTS) 12208845; 15456746; 16227571; 16469925; 16648462; 17498659; 17530637; 18179771; 18628788; 18701507; 19766566; 19828451; 19854137; 19917601; 20003410; 20043883; 20118981; 20368734; 20439491; 20479123; 20547755; 20657587; 20720004; 21047799; 21726812; 23287868; 23318425; 23329852; 23394073; 23970329; 31071955; 31794431; 31881804; 35409160 106 26 531 expression of genes in clusters 8 and 9 by cooperating with H4K16ac, H3K4me2, and H3K4me3 at the transcription start sites (TSSs); HDACi panobinostat induced apoptosis in K562 and K562-IR cells +SERPINF1 PEDF Inhibitor; Secreted; Secreted, signal peptide P36955 5176 17p13.3 human S24-p 455231 SSCQNPAsPPEEGSP molecular association, regulation apoptosis, altered; carcinogenesis, altered; cell motility, altered LEPR(INDUCES) 21059648 2 0 0 +SNAI1 Snail1 C2H2-type zinc finger protein; Transcription factor O95863 6615 20q13.13 human S115-p 6097707 PAPSSFSsTSVSSLE intracellular localization cell motility, altered; transcription, altered 15448698; 19004823 2 0 0 Localization mediated by S107, S111, S115 and S119. +NOS2 iNOS Amino Acid Metabolism - arginine and proline; EC 1.14.13.39; Oxidoreductase P35228 4843 17q11.2 human S745-p 763800 KSRQNLQsPTSSRAT FAD_binding_1 enzymatic activity, induced 17804409 1 1 0 +Slc12a5 KCC2 iso2 Membrane protein, integral; Membrane protein, multi-pass; Transporter; Transporter, SLC family Q63633-2 171373 3q42 rat T1007-p 10045602 DPEKVHLtWTKDKSA SLC12 activity, inhibited 24849604; 26126716 9 5 1 +CASP8 CASP8 iso9 Apoptosis; EC 3.4.22.61; Protease Q14790-9 841 2q33.1 human K215-ub 40190202 RVILGEGkLDILKRV DED carcinogenesis, induced; apoptosis, inhibited 24287696 1 2 0 +FOXN2 FOXN2 DNA-binding P32314 3344 2p16.3 human S365-p 799824601 EDDPLGDsGYASQPC protein degradation; ubiquitination BTRC(INDUCES) 29396548 1 0 0 +AGTR1 AT1 GPCR, family 1; Membrane protein, integral; Membrane protein, multi-pass; Receptor, GPCR P30556 185 3q24 human Y319-p 448745 YFLQLLKyIPPKAKS molecular association, regulation PLCG1(INDUCES) 9516477 5 0 0 +STAT3 STAT3 DNA-binding; Motility/polarity/chemotaxis; Nuclear receptor co-regulator; Transcription factor P40763 6774 17q21.2 human Y640-p 386186603 QIQSVEPyTKQQLNN SH2 molecular association, regulation; protein conformation; phosphorylation carcinogenesis, inhibited; cell growth, inhibited; apoptosis, induced; transcription, induced; transcription, altered; transcription, inhibited DNA(DISRUPTS) 29162862; 30910759; 32231398; 34818414; 36630607 5 0 0 inhibits phosphorylation at Y705; STAT3 hyper activity decrease cell death; inhibits phosphorylation of other sites; inhibits phosphorylation; Y640E mutant showed strongly impaired LIF-dependent reporter transcription, comparable to the Y705F mutant +H3c1 H3 DNA-binding P68433 360198 13|13 A3.1 mouse S57-p 481136 EIRRYQKsTELLIRK Histone molecular association, regulation chromatin organization, altered; transcription, inhibited DNA(DISRUPTS) 26199864 2 19 9 +Atf1 ATF-1 Transcription factor P81269 11908 15|15 F1 mouse S36-p 465558 VHQVSSLsESEESQD molecular association, regulation cell growth, induced; transcription, induced HSF1(INDUCES) 25312646 4 1 0 HSP70 expression, increases cell survival +UHRF1 UHRF1 iso2 DNA-binding; EC 6.3.2.-; EC 6.3.2.19; Ligase; Transcription factor; UBIQUITIN LIGASE; Ubiquitin conjugating system; Ubiquitin ligase Q96T88-2 29128 19p13.3 human S674-p 469962 GGPSRAGsPRRTSKK molecular association, regulation; ubiquitination BRCA1(INDUCES) 26727879 3 12 0 accumulation at DSB sites +Ptgir PTGIR GPCR, family 1; Membrane protein, integral; Membrane protein, multi-pass; Receptor, GPCR P43252 19222 7 A2|7 9.15 cM mouse S355-p 450985 APLSRPAsGRRDPPA molecular association, regulation G-alpha(q)(INDUCES); G-alpha i2(INDUCES) 11443126 3 0 0 +MAPK8IP1 JIP1 Adaptor/scaffold Q9UQF2 9479 11p11.2 human T103-p 449924 LIDATGDtPGAEDDE molecular association, regulation DLK(DISRUPTS) 12756254 2 1 1 +POU2F1 Oct1 DNA-binding; Transcription factor P14859 5451 1q24.2 human S385-p 456220 RRRKKRTsIETNIRV Homeodomain molecular association, regulation; activity, inhibited DNA(DISRUPTS) 1684878 1 14 0 +KDM1A LSD1 DEMETHYLASE; Demethylase; EC 1.-.-.-; Nuclear receptor co-regulator; Oxidoreductase; Transcription factor O60341 23028 1p36.12 human K322-m3 41692103 GRVATFRkGNYVADL Amino_oxidase protein stabilization; molecular association, regulation cell growth, induced; transcription, altered RCOR1(INDUCES) 26183527 1 1 0 lower CDKN1A expression and higher SOX2 expression +CD44 CD44 Cell adhesion; Membrane protein, integral; Motility/polarity/chemotaxis; Receptor, misc. P16070 960 11p13 human S704-p 465561 SGLNGEAsKSQEMVH molecular association, regulation; intracellular localization cell motility, altered MMP9(DISRUPTS) 1281449; 19582779 3 10 10 +GFAP GFAP Cytoskeletal F1RR02 396562 pig S13-p 449619 VTSAARRsYVSSLET Filament_head neural plasticity; cell cycle regulation; cytoskeletal reorganization 1379174; 22528834 11 5 0 +Foxo1 FOXO1A DNA-binding; Nuclear receptor co-regulator; Oncoprotein; Transcription factor Q9R1E0 56458 3 C|3 23.19 cM mouse S246-p 471071 EGGKSGKsPRRRAAS molecular association, regulation; intracellular localization apoptosis, induced; apoptosis, inhibited; transcription, induced; transcription, inhibited DUSP6(INDUCES) 22503562; 22848439; 25673854; 32075913 13 2 2 +Pdgfrb PDGFRB EC 2.7.10.1; KINASE; Kinase, protein; Membrane protein, integral; Oncoprotein; Protein kinase, TK; Protein kinase, tyrosine (receptor) P05622 18596 18 E1|18 34.41 cM mouse Y1008-p 447522 LDTSSVLyTAVQPNE molecular association, regulation; enzymatic activity, induced; phosphorylation cell growth, inhibited; cell differentiation, induced; signaling pathway regulation SHP-2(INDUCES) 11940581; 17018529; 31914388 17 0 0 MEK/ERK1/1 pathway +ULK1 ULK1 Autophagy; EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, Other; Protein kinase, Ser/Thr (non-receptor) O75385 8408 12q24.33 human S556-p 3176155 GLGCRLHsAPNLSDL phosphorylation; enzymatic activity, induced cell cycle regulation; carcinogenesis, induced; cell growth, inhibited; apoptosis, induced; transcription, induced; autophagy, induced; cell growth, induced; apoptosis, inhibited 27864418; 33531625; 34224814; 34421918; 34654847; 34759263; 35316314; 35368866; 35670018; 35740063; 35977966; 36799863; 36927870 61 26 48 induces mitophagy +ACO2 ACO2 Carbohydrate Metabolism - citrate (TCA) cycle; Carbohydrate Metabolism - glyoxylate and dicarboxylate; EC 4.2.1.3; Lyase; Mitochondrial Q99798 50 22q13.2 human K258-ac 1875261900 VAGILTVkGGTGAIV Aconitase enzymatic activity, induced transcription, inhibited 33115805 1 1 0 K258 acetylation of ACO2 is important for its optimal enzyme activity and function in prostate cancer cells: AR and its coregulator SRC-2 repress SIRT3 expression and maintain high levels of acetylated K258. +STAT1 STAT1 DNA-binding; Transcription factor P42224 6772 2q32.2 human K703-sm 3278913 PKGTGYIkTELISVS molecular association, regulation; phosphorylation transcription, inhibited DNA(DISRUPTS) 12855578; 15761017; 17277783; 19174562; 23043228 9 3 0 selective transcription of IFN-gamma mediated genes +Irgm1 IRGM EC 3.6.5.-; Endoplasmic reticulum; Hydrolase Q60766 15944 11|11 B1.2 mouse K398-ub 27194825 DTKNILEkILRDSIF IIGP protein degradation 35197566 1 2 0 +UBTF UBF DNA-binding; Nucleolus; Transcription factor P17480 7343 17q21.31 human K254-m3 31094521 HKALEQRkEYEEIMR HMG_box molecular association, regulation chromatin organization, altered; transcription, inhibited 24234436 1 1 0 +NR1H2 LXR-beta Nuclear receptor P55055 7376 19q13.33 human S426-p 18502600 RMLMKLVsLRTLSSV Hormone_recep molecular association, regulation transcription, induced coronin 2A(DISRUPTS); SENP3(INDUCES) 21331046 1 0 1 +RELA NFkB-p65 DNA-binding; Nuclear receptor co-regulator; Transcription factor Q04206 5970 11q13.1 human K314-m1 7493900 ETFKSIMkKSPFSGP protein degradation transcription, inhibited 19262565 2 1 0 +SHC3 SHC3 Adaptor/scaffold; Motility/polarity/chemotaxis Q92529 53358 9q22.1 human Y424-p 451259 PTGEAPTyVNTQQIP apoptosis, inhibited 12242309 3 0 1 +NEDD1 NEDD1 Cell cycle regulation Q8NHV4 121441 12q23.1 human T550-p 6225645 PPINGSStPNPKIAS molecular association, regulation; phosphorylation cell cycle regulation PLK1(INDUCES) 19509060; 21690413 3 2 6 +PLD2 PLD2 EC 3.1.4.4; Lipid Metabolism - ether lipid; Lipid Metabolism - glycerophospholipid; Motility/polarity/chemotaxis; Phospholipase O14939 5338 17p13.2 human Y169-p 458806 KQKYLENyLNRLLTM PX molecular association, regulation; enzymatic activity, induced cell motility, altered; cell growth, altered GRB2(INDUCES) 16407827; 20647543 2 0 0 +Slc12a3 NCCT Membrane protein, integral; Membrane protein, multi-pass; Transporter; Transporter, SLC family P59158 20497 8 C5|8 46.46 cM mouse T53-p 469616 GSTLYMRtFGYNTID AA_permease_N activity, induced; ubiquitination 22846565; 25472608 25 3 0 +IFNGR1 IFNGR1 Membrane protein, integral; Receptor, cytokine P15260 3459 6q23.3 human Y457-p 451253 KAPTSFGyDKPHVLV molecular association, regulation cell cycle regulation; transcription, altered STAT1(INDUCES) 11390994; 8156998 4 4 34 Induced with serum and IFN-gamma +Npr2 ANPB EC 4.6.1.2; Guanylyl cyclase; KINASE; Kinase, protein; Lyase; Membrane protein, integral; Nucleotide Metabolism - purine; Protein kinase, RGC; Protein kinase, dual-specificity (receptor); Receptor, misc. P16067 116564 5q22 rat S526-p 450024 LRGSSYGsLMTAHGK PK_Tyr_Ser-Thr activity, induced 9624142 2 4 0 +DGCR8 DGCR8 Nucleolus; RNA processing; RNA-binding Q8WYQ5 54487 22q11.21 human Y267-p 479394 KRRTEEKyGGDSDHP molecular association, regulation; protein stabilization RNA(DISRUPTS) 24239349; 26126715 1 11 3 stimulates pri-miR-34c processing +Hmgb1 HMGB1 DNA repair, damage; Nuclear receptor co-regulator P63159 25459 19q12 rat K3-ac 459196 _____MGkGDPKKPR intracellular localization; phosphorylation 19166815; 21257610; 22740141 8 1 0 acetylated residues inhibit it's phosphorylation; induces phosphorylation at S181; inhibits phosphorylation +CSNK1D CK1D EC 2.7.11.1; EC 2.7.11.26; KINASE; Kinase, protein; Protein kinase, CK1; Protein kinase, Ser/Thr (non-receptor) P48730 1453 17q25.3 human T176-p 1868926302 ENKNLTGtARYASIN Pkinase enzymatic activity, induced 31096047 1 1 0 +Frs2 FRS2 Adaptor/scaffold Q8C180 327826 10|10 D2 mouse Y471-p 473102 PTRRTELyAVIDIER molecular association, regulation SHP-2(NOT_REPORTED) 9632781 2 2 15 +HSPB1 HSP27 Chaperone; Heat shock protein; Motility/polarity/chemotaxis; SUMO LIGASE; SUMO ligase P15991 hamster S15-p 448401 FSLLRSPsWEPFRDW activity, induced; molecular association, regulation; protein conformation apoptosis, altered IKKA(INDUCES); HSP27(DISRUPTS) 15033973; 15944157; 16840786; 31441240 52 78 30 +Yy1 YY1 C2H2-type zinc finger protein; Cell development/differentiation; Transcription factor Q00899 22632 12 F1|12 59.58 cM mouse T30-p 25236712 LHEIEVEtIPVETIE molecular association, regulation; phosphorylation transcription, induced; signaling pathway regulation CBX4(DISRUPTS) 22482732 1 0 0 +APP APP iso4 Apoptosis; Cell surface; Membrane protein, integral; Receptor, misc.; Transcription factor P05067-4 351 21q21.3 human Y687-p 450343 NGYENPTyKFFEQMQ APP_amyloid protein stabilization; protein processing; intracellular localization 17596701; 17873282 4 12 238 +H3C1 H3 DNA-binding P68431 8350 6p22.2 human K122-ub 10834888 KRVTIMPkDIQLARR Histone molecular association, regulation SMARCC2(DISRUPTS) 32188943 0 10 31 cryo-EM; Rsc4 in yeast +NPM1 NPM1 Nucleolus; Oncoprotein; RNA-binding; Translation P06748 4869 5q35.1 human T219-p 449023 KDSKPSStPRSKGQE molecular association, regulation RNA(DISRUPTS) 12058066 1 20 24 +HNRNPD hnRNP D0 RNA splicing; RNA-binding Q14103 3184 4q21.22 human S87-p 449337 SNSSPRHsEAATAQR phosphorylation transcription, induced; RNA stability, altered RNA(INDUCES) 11903055; 12819194; 36041631 4 14 0 +NOLC1 NOLC1 Nucleolus; RNA-binding; Transcription, coactivator/corepressor Q14978 9221 10q24.32 human S563-p 470282 NGKAAKNsEEEEEEK molecular association, regulation CK2A1(INDUCES) 24218616 1 59 38 +RGS10 RGS10 iso1 GAP; GAP, RGS O43665-1 6001 10q26.11 human S168-p 455907 QTAAKRAsRIYNT__ intracellular localization apoptosis, inhibited; signaling pathway regulation 11443111; 22564151 3 3 7 PKA-CREB-Bcl2 anti-apoptotic pathway +Map2 MAP2 iso3 Cytoskeletal; Motility/polarity/chemotaxis P15146-3 25595 9q32 rat K364-ac 62495513 RPGGGRVkIESVKLD Tubulin-binding cytoskeletal reorganization 28002468 1 1 0 +Rela NFkB-p65 DNA-binding; Nuclear receptor co-regulator; Transcription factor Q04207 19697 19 A|19 4.34 cM mouse S534-p 447800 SGDEDFSsIADMDFS activity, induced; protein degradation; molecular association, regulation; intracellular localization; protein processing; phosphorylation cell differentiation, inhibited; carcinogenesis, induced; cell motility, induced; apoptosis, induced; transcription, induced; signaling pathway regulation; transcription, altered; chromatin organization, altered; cell growth, induced; transcription, inhibited p300(INDUCES); p90RSK(INDUCES) DNA(DISRUPTS) 15858576; 16135789; 16498455; 18056447; 19609947; 19965984; 20710027; 27555662; 31932498; 32161168; 32473126; 33537817; 33684929; 33930463; 34082382; 34161773; 34380537; 34496234; 35051616; 35210557; 35449211; 35637461; 35641033; 36081816; 36223242; 36309088; 36416450; 36938407; 37311534; 37392853 254 4 0 +Klc1 KLC1 Microtubule-binding; Motor O88447 16593 12 F1|12 61.13 cM mouse S459-p 477826 YKACKVDsPTVTTTL molecular association, regulation CLSTN1(DISRUPTS) 21385839 3 41 3 +Scn8a SCN8A Channel, sodium; Membrane protein, integral; Membrane protein, multi-pass Q9WTU3 20273 15 56.39 cM|15 F1 mouse Y1945-p 14828400 STASLPSyDSVTKPD molecular association, regulation; activity, inhibited NEDD4L(INDUCES) 20530479 1 0 0 +Nr3c1 GR DNA-binding; Mitochondrial; Nuclear receptor; Transcription factor P06536 24413 18p11 rat K313-sm 2532300 LCTPGVIkQEKLGPV GCR transcription, inhibited 14663148 7 3 0 +Abl1 Abl EC 2.7.10.2; KINASE; Kinase, protein; Oncoprotein; Protein kinase, TK; Protein kinase, tyrosine (non-receptor) P00520 11350 2 21.86 cM|2 B mouse T547-p 450294 EQKDAPDtPELLHTK enzymatic activity, induced cytoskeletal reorganization 15632178 2 0 0 +HSP90AA1 HSP90A Chaperone; Heat shock protein P07900 3320 14q32.31 human T90-p 476047 NKQDRTLtIVDTGIG HATPase_c molecular association, regulation exocytosis, altered; cell growth, altered HSP70(DISRUPTS); CHIP(INDUCES); PKCG(DISRUPTS); STI1(DISRUPTS); Src(DISRUPTS); PPP5C(INDUCES); TEBP(INDUCES); CDC37(DISRUPTS); AHSA1(INDUCES); Akt1(DISRUPTS) 19965370; 21919888 2 2 1 HSP90 secretion leading to proinvasiveness; T90 phosphorylation regulates the HSP90A co-chaperone machinery and binding affinity with client proteins. +ACO1 IREB1 Carbohydrate Metabolism - citrate (TCA) cycle; Carbohydrate Metabolism - glyoxylate and dicarboxylate; EC 4.2.1.3; Endoplasmic reticulum; Lyase; RNA-binding; Translation P21399 48 9p21.1 human S138-p 451387 DFNRRADsLQKNQDL Aconitase protein degradation; molecular association, regulation; enzymatic activity, inhibited cell growth, induced RNA(INDUCES) 12972614; 16424901; 19269970; 28768766 6 0 1 maintain cell viability +MAP4 MAP4 Cytoskeletal; Motility/polarity/chemotaxis P27816 4134 3p21.31 human K871-ac 62495525 TSTSSMKkTTTLSGT cytoskeletal reorganization 28002468 1 1 0 +CCDC50 CCDC50 Inhibitor Q8IVM0 152137 3q28 human Y217-p 6377637 MAEEKKAyKKAKERE phosphorylation apoptosis, inhibited; cell growth, altered 19059208 1 0 0 ; inhibits NF-kB activity; inhibits phosphorylation of IKKbeta through TNFalpha +CDC14A CDC14A EC 3.1.3.16; EC 3.1.3.48; Motility/polarity/chemotaxis; PHOSPHATASE; Protein phosphatase, dual-specificity Q9UNH5 8556 1p21.2 human S549-p 1216243800 SNGGNLNsPPGPHSA molecular association, regulation 30089874 1 1 0 interaction with putative unknown substrates or regulators +MAP3K11 MLK3 EC 2.7.11.25; KINASE; Kinase, protein; Protein kinase, Ser/Thr (non-receptor); Protein kinase, TKL Q16584 4296 11q13.1 human S770-p 448612 LISRPRPsPLRSRID phosphorylation; enzymatic activity, induced cell cycle regulation; carcinogenesis, induced; cell growth, induced 35843311 2 4 0 +Ptpn5 STEP EC 3.1.3.48; Membrane protein, multi-pass; Motility/polarity/chemotaxis; PHOSPHATASE; Protein phosphatase, tyrosine (non-receptor) P35234 29644 1q22 rat S49-p 448294 GLQERRGsNVSLTLD ubiquitination; enzymatic activity, inhibited 20427654 9 0 0 +Ptpn12 PTP-PEST EC 3.1.3.48; Motility/polarity/chemotaxis; PHOSPHATASE; Protein phosphatase, tyrosine (non-receptor) P35831 19248 5|5 A3 mouse S39-p 451311 FMRLRRLsTKYRTEK molecular association, regulation; intracellular localization; enzymatic activity, inhibited cell motility, induced; cell adhesion, induced SKAP2(DISRUPTS) 19919952; 23897807; 36250939 5 0 15 +Pi4k2a PI4K2A EC 2.7.1.67; Kinase, lipid; Motility/polarity/chemotaxis Q2TBE6 84095 19 C3|19 35.74 cM mouse S47-p 468434 AAAGSGPsPPCSPGH protein degradation; molecular association, regulation; intracellular localization LAMP1(INDUCES); AP3D1(INDUCES) 25083612 2 73 6 Regulates the lysosomal degradation +Stxbp1 STXBP1 Vesicle O08599 20910 2 B|2 22.09 cM mouse Y473-p 450386 ERISEQTyQLSRWTP Sec1 protein conformation exocytosis, inhibited 29150433 1 4 212 prevents SNARE assembly, inhibits SNARE-dependent membrane fusion, inhibition of synaptic transmission in neurons +GNB2 G-beta 2 G protein; G protein, heterotrimeric; G protein, heterotrimeric beta P62879 2783 7q22.1 human K23-ub 8100707 NQIRDARkACGDSTL phosphorylation signaling pathway regulation 34342229 1 9 27 KCTD2/KCTD5-CUL3-RING E3 ligase promotes cAMP signaling in cancer-derived cell lines +FANCD2 FANCD2 DNA repair, damage Q9BXW9 2177 3p25.3 human S882-p 1871613600 DGSKTSSsDTLSEEK FancD2 molecular association, regulation; ubiquitination; intracellular localization; activity, inhibited cell cycle regulation; DNA repair, inhibited; signaling pathway regulation DNA(DISRUPTS) 31167143 1 1 0 inhibits Fanconi anemia pathway leading to inhibition of DNA repair; 882-898 cluster +PSEN2 PSEN2 Cell surface; EC 3.4.23.-; Membrane protein, integral; Membrane protein, multi-pass; Protease P49810 5664 1q42.13 human S327-p 448564 DPEMEEDsYDSFGEP Presenilin; Presenilin protein stabilization apoptosis, inhibited 9990034 2 0 0 Phosphorylation of Presenilin 2 inhibits its cleavage by caspase-3. +FOXO4 FOXO4 DNA-binding; Oncoprotein; Transcription factor P98177 4303 Xq13.1 human T455-p 448570 ALGTPVLtPPTEAAS intracellular localization cell cycle regulation; transcription, induced 11689711; 15538382 3 3 0 +MAP3K5 ASK1 EC 2.7.11.25; KINASE; Kinase, protein; Protein kinase, STE; Protein kinase, Ser/Thr (non-receptor) Q99683 4217 6q23.3 human T813-p 990312 GDNVLINtYSGVLKI Pkinase transcription, altered 17937911 1 0 0 +PDK1 PDHK1 EC 2.7.11.2; KINASE; Kinase, protein; Mitochondrial; Protein kinase, Ser/Thr (non-receptor); Protein kinase, atypical Q15118 5163 2q31.1 human T346-p 13831355 APRPRVEtSRAVPLA HATPase_c enzymatic activity, induced cell growth, induced 27505672 1 3 0 mitochondrial Akt-PDK1 signaling in maintaining tumor cell proliferation in hypoxia +Cttn Cortactin Actin-binding; Cytoskeletal; Motility/polarity/chemotaxis Q60598 13043 7|7 F5 mouse K181-ac 3807125 VGFDYQGkTEKHESQ HS1_rep molecular association, regulation; acetylation; intracellular localization DIP2A(INDUCES) 31600191 1 2 4 DIP2A regulates spine morphology and synaptic transmission through acetylation of cortactin; Interaction of DIP2A-cortactin is required for acetylated cortactin; acetylation mimetic cortactin rescues the repetitive behaviors in Dip2a KO mice; acetylation alleviated abnormal PSD95 clustering at the spine head in DIP2A KO neurons +THOC5 FMIP Cell development/differentiation; RNA splicing; Spliceosome Q13769 8563 22q12.2 human S5-p 453432 ___MSSEsSKKRKPK intracellular localization 15221008 1 0 0 +RAF1 RAF1 EC 2.7.11.1; KINASE; Kinase, protein; Oncoprotein; Protein kinase, Ser/Thr (non-receptor); Protein kinase, TKL P04049 5894 3p25.2 human S338-p 447742 RPRGQRDsSYYWEIE activity, induced; molecular association, regulation; intracellular localization; protein conformation; phosphorylation; enzymatic activity, induced cell cycle regulation; carcinogenesis, induced; cell growth, inhibited; cell growth, induced; apoptosis, inhibited; signaling pathway regulation Bcl-2(INDUCES); RAF1(DISRUPTS); PLK1(INDUCES); MEK1(INDUCES); 14-3-3 beta(DISRUPTS) 10712905; 10998357; 11274179; 11447113; 12077328; 12244094; 12446733; 12551923; 12719581; 12865432; 15470067; 15849194; 16129686; 16585161; 18775988; 19282665; 19595761; 22081024; 22169110; 31213532; 35417664; 35697074; 9234708; 9823899 92 2 7 +Stmn1 STMN1 Cytoskeletal P13668 29332 5q36 rat S16-p 448554 KELEKRAsGQAFELI Stathmin apoptosis, inhibited; cytoskeletal reorganization TUBA1B(DISRUPTS); TUBB(DISRUPTS) 16982419; 25285524; 31933182 38 98 61 increase microtubule depolymerization +TP53 p53 Activator; DNA-binding; Motility/polarity/chemotaxis; Nuclear receptor co-regulator; Transcription factor; Tumor suppressor P04637 7157 17p13.1 human K320-ne 486297 SSSPQPKkKPLDGEY P53_tetramer activity, inhibited transcription, inhibited 17098746 1 0 0 +ATG16L1 ATG16L1 Adaptor/scaffold; Autophagy; Membrane protein, peripheral Q676U5 55054 2q37.1 human K151-m1 1079821901 ECLDLRTkLCDLERA ATG16 apoptosis, induced; autophagy, inhibited 29634390 1 1 0 methylation at K151 inhibits phosphorylation of ATG16L1 at S139 +FERMT2 kindlin-2 Cytoskeletal; Motility/polarity/chemotaxis Q96AC1 10979 14q22.1 human S180-p 3208611 PGSGSIYsSPGLYSK protein degradation; molecular association, regulation; ubiquitination cell cycle regulation; cell growth, induced; apoptosis, inhibited; cytoskeletal reorganization; cell adhesion, inhibited CUL9(INDUCES) 35469017 1 4 2 +Nr4a2 NR4A2 DNA-binding; Nuclear receptor Q06219 18227 2 C1.1|2 31.66 cM mouse S126-p 487424 SVYYKPSsPPTPSTP intracellular localization 25752609 3 0 0 cytoplasmic translocation, required for H2O2-induced necrosis +FLT1 VEGFR1 EC 2.7.10.1; KINASE; Kinase, protein; Membrane protein, integral; Protein kinase, TK; Protein kinase, tyrosine (receptor) P17948 2321 13q12.3 human Y794-p 455807 SSEIKTDyLSIIMDP phosphorylation cell cycle regulation; cell differentiation, altered 11350975; 16946136 2 0 1 angiogenesis +FYN Fyn EC 2.7.10.2; KINASE; Kinase, protein; Oncoprotein; Protein kinase, TK; Protein kinase, tyrosine (non-receptor) P06241 2534 6q21 human Y531-p 447883 FTATEPQyQPGENL_ activity, induced; intracellular localization; enzymatic activity, inhibited; protein conformation; phosphorylation cell growth, altered 1533589; 15713745; 17389760; 1985196 19 15 1040 Localization of Fyn is modulated by PDEF in cells expressing wild-FES (WT6-8 cells) , but not in cells with inactive FES (KE5-15). +Xrcc6 Ku70 DNA repair, damage; DNA-binding; EC 3.6.4.-; EC 4.2.99.-; Helicase; Nuclear receptor co-regulator; RNA-binding P23475 14375 15 E1|15 38.33 cM mouse S6-p 452070 __MSEWEsYYKTEGE molecular association, regulation BAX(DISRUPTS) 19664609 3 7 0 kainate treatment increases interaction of Ku70 with Bax +CASTOR1 GATSL3 Q8WTX7 652968 22q12.2 human S14-p 25293269 EHRVRVLsVARPGLW Castor1_N protein degradation; molecular association, regulation; ubiquitination; protein conformation; enzymatic activity, induced cell cycle regulation; carcinogenesis, induced; cell growth, induced RNF167(INDUCES); WDR59(DISRUPTS); MIOS(DISRUPTS); WDR24(DISRUPTS) 33594058; 37083230 2 0 1 induces mTORC1 activity +ZNF746 PARIS C2H2-type zinc finger protein; Transcription regulation Q6NUN9 155061 7q36.1 human K286-sm 55465778 EDVKIVIkTEVQEEE transcription, inhibited 33077496 2 2 0 +NDFIP2 NDFIP2 Adaptor/scaffold; Membrane protein, integral; Membrane protein, multi-pass Q9NV92 54602 13q31.1 human Y171-p 15229530 TEVYGEFyPVPPPYS DUF2370 molecular association, regulation; phosphorylation LYN(INDUCES) 20534535 1 0 1 Y167, Y177 and Y186 phosphorylation are dependent on Y171 phosphorylation +Rps6ka3 RSK2 EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, AGC; Protein kinase, Ser/Thr (non-receptor) P18654 110651 X F4|X 73.27 cM mouse S386-p 448065 HQLFRGFsFVAITSD Pkinase_C molecular association, regulation; phosphorylation; enzymatic activity, induced PDK1(INDUCES) 10480933; 10856237 14 19 59 +Nr4a2 NR4A2 DNA-binding; Nuclear receptor Q07917 54278 3q21 rat K91-sm 2407417 SGQQSSIkVEDIQMH transcription, inhibited 14559918; 23358114 2 0 0 +CDCA8 Borealin Cell cycle regulation; Nucleolus Q53HL2 55143 1p34.3 human S275-p 482836 RLAQICSsIRTHK__ Borealin cell growth, altered 17483322 1 1 0 +Bub1 BUB1 Cell cycle regulation; EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, Other; Protein kinase, Ser/Thr (non-receptor) O08901 12235 2 F1|2 62.1 cM mouse T449-p 4275007 CKVQPSPtVHTKEAL molecular association, regulation; protein conformation Mad1(INDUCES) 34013668 2 1 0 +ELK1 ELK1 DNA-binding; Transcription factor P19419 2002 Xp11.23 human K249-sm 3982500 RALPPEVkVEGPKEE sumoylation; intracellular localization cell differentiation, inhibited; transcription, induced; transcription, inhibited 14992729; 15210726; 17036045; 30789974 6 1 0 Both ELK1 and ELK-3R promote transcription, K230R, K249R, K254R does not prevent ELK1 SUMOylation, ELK1 and ELK1-3R show same intracellular localization +YAP1 YAP1 Oncoprotein; Transcription, coactivator/corepressor P46937 10413 11q22.1 human K252-ub 1881250301 EIYYINHkNKTTSWL protein degradation; ubiquitination cell motility, inhibited 33939216 2 0 0 TNBC cell migration and invasion +Naca NACA iso2 Motility/polarity/chemotaxis; Transcription, coactivator/corepressor Q60817 17938 10|10 D3 mouse S99-p 31834914 TRVTIRKsKNILFVI NAC intracellular localization transcription, induced 24550008; 35055125 2 1 0 +PRKG1 PKG1 EC 2.7.11.12; KINASE; Kinase, protein; Protein kinase, AGC; Protein kinase, Ser/Thr (non-receptor) P00516 282004 cow T517-p 452153 GFGKKTWtFCGTPEY Pkinase enzymatic activity, induced 29602907 3 4 13 activation loop of the catalytic domain +GYS1 GYS1 Carbohydrate Metabolism - starch and sucrose; EC 2.4.1.11; Transferase P13807 2997 19q13.33 human T278-p 1875332700 KRKPDIVtPNGLNVK Glycogen_syn phosphorylation 34758018 1 1 0 primes phopshorylation at S641 +EZH2 EZH2 EC 2.1.1.43; METHYLTRANSFERASE; Methyltransferase; Methyltransferase, protein lysine Q15910 2146 7q36.1 human S76-gl 31823503 HILTSVSsLRGTREC protein stabilization; methylation carcinogenesis, induced 24474760 1 1 0 increases H3K27me3 +Mafa MAFA DNA-binding; Oncoprotein; Transcription factor; Tumor suppressor Q8CF90 378435 15|15 D3 mouse K32-sm 6124705 DLMKFEVkKEPPEAE cell growth, inhibited; transcription, inhibited 20718938 2 0 0 +H3C1 H3 DNA-binding P68431 8350 6p22.2 human T45-p 455679 PHRYRPGtVALREIR Histone molecular association, regulation apoptosis, induced; transcription, altered DNA(INDUCES) 19363025; 22158034 5 7 3 repression of E-cadherin expression, upregulation of fibronectin expression +MAP3K7 TAK1 EC 2.7.11.25; KINASE; Kinase, protein; Protein kinase, Ser/Thr (non-receptor); Protein kinase, TKL O43318 6885 6q15 human T178-p 3303400 LKICDFGtACDIQTH PK_Tyr_Ser-Thr phosphorylation; enzymatic activity, induced 18617512; 20538596 3 0 0 facilitates autophosphorylation of T184 and T187 +NPM1 NPM1 Nucleolus; Oncoprotein; RNA-binding; Translation P06748 4869 5q35.1 human T237-p 449560 KQEKTPKtPKGPSSV molecular association, regulation; intracellular localization cell cycle regulation; cell motility, induced; cell growth, induced; cytoskeletal reorganization ROCK2(INDUCES) RNA(DISRUPTS) 12058066; 14670079; 26536659; 26993766; 30453269 7 26 21 stress fiber formation was enhanced, invasion and migration of HCC cells +Btk Btk EC 2.7.10.2; KINASE; Kinase, protein; Protein kinase, TK; Protein kinase, tyrosine (non-receptor) P35991 12229 X E3|X 56.18 cM mouse S115-p 463807 EGPLYVFsPTEELRK PH molecular association, regulation PIN1(INDUCES) 16644721 1 0 0 Interaction with Pin1 negatively regulates Btk expression. +Wnk4 WNK4 EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, Other; Protein kinase, Ser/Thr (non-receptor) Q80UE6 69847 11|11 D mouse K1123-ub 40323304 ELQNLRQkHLSEVEA protein degradation 23576762 1 1 0 regulates electrolyte homeostasis and involved in Pseudohypoaldosteronism type II (PHAII) pathogenesis +PPP1R1C PPP1R1C Motility/polarity/chemotaxis; Protein phosphatase, regulatory subunit Q8WVI7 151242 2q31.3-q32.1 human T34-p 2807902 QIRKRRPtPASLVIL DARPP-32 activity, induced cell cycle regulation; cell growth, altered 18310074 1 0 0 activates inhibition of PP1, and increases cell growth +PRKCD PKCD EC 2.7.11.13; KINASE; Kinase, protein; Nuclear receptor co-regulator; Protein kinase, AGC; Protein kinase, Ser/Thr (non-receptor); Protein kinase, tyrosine (non-receptor); Tumor suppressor Q05655 5580 3p21.1 human T507-p 447511 FGESRAStFCGTPDY Pkinase sumoylation; intracellular localization; phosphorylation; enzymatic activity, induced apoptosis, altered; signaling pathway regulation 12393602; 16505477; 18652571; 21730054; 24632950; 28784722; 31511386; 34089566 51 21 108 PKCD T507A mutant caused apoptosis in transfected HEK293T cells, similar to the wild-type. ; phosphorylation induces sumoylation which reciprocally induces phosphorylation; Histamine/PMA-induced PKCD/ERK/PARP1 signaling pathway for H1R gene regulation; 507A disrupts DKD activity; induces phosphorylation of lamin A/C +XRCC1 XRCC1 DNA repair, damage P18887 7515 19q13.31 human K431-ac 1878191201 EAPKLPQkQPQTKTK protein degradation 31043584 1 1 0 +KIR3DL1 KIR3DL1 Membrane protein, integral; Receptor, misc. P43629 3811 19q13.42 human S385-p 990304 AGNRTANsEDSDEQD activity, induced; receptor internalization, altered 17911614 1 0 0 +AKT1 Akt1 EC 2.7.11.1; KINASE; Kinase, protein; Oncoprotein; Protein kinase, AGC; Protein kinase, Ser/Thr (non-receptor) P31749 207 14q32.33 human K8-ub 12723503 MSDVAIVkEGWLHKR PH intracellular localization; phosphorylation; enzymatic activity, induced 19713527 2 3 0 promotes Akt membrane recruitment and phosphorylation, resulting in activation +Eps8 EPS8 Adaptor/scaffold Q08509 13860 6 G1|6 66.78 cM mouse T628-p 9467900 SAPSPPPtPAPVPVP intracellular localization cytoskeletal reorganization 19564905 1 1 1 +PLK4 PLK4 EC 2.7.11.21; KINASE; Kinase, protein; Nucleolus; Protein kinase, Other; Protein kinase, Ser/Thr (non-receptor) O00444 10733 4q28.1 human K46-ac 62518202 AIKMIDKkAMYKAGM Pkinase enzymatic activity, inhibited; protein conformation; phosphorylation cell cycle regulation 27796307 1 1 0 inhibits phosphorylation of its kinase domain, prevents centrosome amplification +Ankrd54 ANKRD54 Cell cycle regulation Q91WK7 223690 15 E1|15 37.7 cM mouse S19-p 239773906 SRSGRSSsDGECAVA molecular association, regulation; intracellular localization LYN(INDUCES) 28924458 1 1 0 nuclear export, cytoplasmic accumulation +Grin2b NMDAR2B Channel, calcium; Channel, ligand-gated; Membrane protein, integral; Membrane protein, multi-pass Q01097 14812 6 G1|6 66.38 cM mouse Y1070-p 461055 ISTHTVTyGNIEGNA NMDAR2_C molecular association, regulation; phosphorylation neural plasticity; signaling pathway regulation Fyn(INDUCES) 26229100; 34433031 3 2 136 induces phosphorylation at Y1472, regulates mTOR signaling; regulated by synaptic activity +BMX Etk EC 2.7.10.2; KINASE; Kinase, protein; Protein kinase, TK; Protein kinase, tyrosine (non-receptor) P51813 660 Xp22.2 human Y566-p 448067 RYVLDDQyVSSVGTK PK_Tyr_Ser-Thr protein stabilization; molecular association, regulation apoptosis, induced; cell growth, altered STAT3(INDUCES); PIK3R1(INDUCES) 10688651; 14532277; 27601470 3 1 4 +Ctnnd1 CTNND1 Actin-binding; Adaptor/scaffold; Cell adhesion; G protein regulator, misc.; Motility/polarity/chemotaxis P30999 12388 2 D|2 49.45 cM mouse Y257-p 450397 APSRQDVyGPQPQVR cell cycle regulation; cell motility, altered 18515860 2 27 754 +PPARGC1A PGC-1 alpha Nuclear receptor co-regulator; Transcription, coactivator/corepressor Q9UBK2 10891 4p15.2 human S266-p 448008 SLPLTPEsPNDPKGS protein stabilization 11741533 3 3 0 +POLDIP3 SKAR RNA-binding Q9BY77 84271 22q13.2 human S383-p 454010 ELPRRVNsASSSNPP activity, induced ERH(NOT_REPORTED) 15341740; 16984396 2 5 8 phosphorylation of this site is involved in the control of cell growth +DEPTOR DEPTOR Apoptosis Q8TB45 64798 8q24.12 human S291-p 4723858 CGSSGYFsSSPTLSS protein degradation; molecular association, regulation; ubiquitination BTRC(INDUCES); FBW1B(INDUCES) 22017876; 22017877 2 1 0 +BORA BORA Activator Q6PGQ7 79866 13q21.33 human T501-p 2512943 QMDSGYNtQNCGSNI protein degradation; molecular association, regulation; ubiquitination cell cycle regulation BTRC(INDUCES); BRD8(INDUCES) 18378770; 18521620; 23592782; 34759346 5 0 0 +FGFR2 FGFR2 iso18 EC 2.7.10.1; KINASE; Kinase, protein; Membrane protein, integral; Oncoprotein; Protein kinase, TK; Protein kinase, tyrosine (receptor) P21802-18 2263 10q26.13 human Y656-p 472825 DINNIDYyKKTTNGR PK_Tyr_Ser-Thr molecular association, regulation; intracellular localization CD44(INDUCES) 27107424 2 6 36 colocalization with CD44 +HJURP HJURP Histone-binding; Nucleolus Q8NCD3 55355 2q37.1 human S412-p 453537 RTLKWLIsPVKIVSR HJURP_C molecular association, regulation; intracellular localization cell cycle regulation OIP5(DISRUPTS) 24519934; 28017591 2 25 8 prevents premature CENP-A assembly; Mis18 binds with HJURP and specifies the centromere localization +Prkcd PKCD EC 2.7.11.13; KINASE; Kinase, protein; Nuclear receptor co-regulator; Protein kinase, AGC; Protein kinase, Ser/Thr (non-receptor); Protein kinase, tyrosine (non-receptor); Tumor suppressor P28867 18753 14 B|14 18.82 cM mouse Y64-p 447581 TTFDAHIyEGRVIQI molecular association, regulation; intracellular localization; enzymatic activity, inhibited carcinogenesis, inhibited; apoptosis, induced KPNA2(INDUCES) 11739733; 11812791; 18059334; 21865164 7 3 31 PKCD-induced apoptosis +Camkk1 CAMKK1 EC 2.7.11.17; KINASE; Kinase, protein; Protein kinase, Other; Protein kinase, Ser/Thr (non-receptor) P97756 60341 10q24 rat S458-p 486077 KSMLRKRsFGNPFEP molecular association, regulation; enzymatic activity, inhibited Calmodulin(DISRUPTS) 9195898 5 25 21 +Asic1 ASIC1 Channel, cation; Membrane protein, integral; Membrane protein, multi-pass; Transporter; Transporter, ion channel P55926 79123 7q36 rat S476-p 458230 CQKEAKRsSADKGVA activity, inhibited apoptosis, altered 16301179 1 0 0 +RBM25 RBM25 RNA splicing; RNA-binding; Spliceosome P49756 58517 14q24.2 human K77-m1 58123403 DHPGLKAkENDENCG molecular association, regulation L3MBTL iso4(INDUCES) 23583077 0 1 0 +PTPN5 STEP EC 3.1.3.48; Membrane protein, multi-pass; Motility/polarity/chemotaxis; PHOSPHATASE; Protein phosphatase, tyrosine (non-receptor) P54829 84867 11p15.1 human T255-p 20745210 SLTLDMCtPGCNEEG protein stabilization 21777200 1 0 0 +Lck Lck EC 2.7.10.2; KINASE; Kinase, protein; Oncoprotein; Protein kinase, TK; Protein kinase, tyrosine (non-receptor) P06240 16818 4 D2.2|4 63.26 cM mouse Y394-p 447822 RLIEDNEyTAREGAK PK_Tyr_Ser-Thr molecular association, regulation; intracellular localization; phosphorylation; enzymatic activity, induced carcinogenesis, induced; carcinogenesis, inhibited; cell motility, induced; transcription, induced; signaling pathway regulation; cell differentiation, induced; cell growth, induced; cell motility, altered BAT3(INDUCES) 12121665; 14699120; 17719247; 2250907; 22863785; 27271569; 33420490; 33684096; 35150959; 35638332; 36376335 62 96 2957 induces phosphorylation of PLCG1, LAT and ZAP70 +VAMP8 VAMP8 Membrane protein, integral; Vesicle Q9BV40 8673 2p11.2 human S55-p 12738929 TEDLEATsEHFKTTS Synaptobrevin activity, inhibited 27402227 1 10 0 abolish function in SNARE complex during mast cell secretion, reduces in vitro ensemble vesicle fusion +NPM1 NPM1 Nucleolus; Oncoprotein; RNA-binding; Translation P06748 4869 5q35.1 human Y67-p 3179290 VEAEAMNyEGSPIKV Nucleoplasmin protein conformation NPM1(DISRUPTS) 25490769 1 18 6 destabilizes oligomers +Smurf1 SMURF1 EC 6.3.2.-; EC 6.3.2.19; Ligase; UBIQUITIN LIGASE; Ubiquitin conjugating system; Ubiquitin ligase Q9CUN6 75788 5|5 G2 mouse T306-p 18156100 VDHNNRTtQFTDPRL WW intracellular localization cell growth, altered 21262463 2 0 0 alters SMURF1 substrate affinity and preference; contributes to neuronal polarization by promoting axon formation +Sik1 SIK EC 2.7.11.1; KINASE; Kinase, protein; Motility/polarity/chemotaxis; Protein kinase, CAMK; Protein kinase, Ser/Thr (non-receptor); Tumor suppressor Q9R1U5 59329 20p12 rat S577-p 465992 FQEGRRAsDTSLTQG intracellular localization transcription, induced; transcription, altered 12530628; 15511237; 23349925 10 21 4 Wild-type and S577A mutant induce MEF2 transcriptional activity and are nuclear localized.; S577 may be involved in nuclear export from the nucleus. +BCL10 Bcl-10 Apoptosis; Transcription, coactivator/corepressor; Tumor suppressor O95999 8915 1p22.3 human S134-p 467254 DGATNNLsRSNSDES activity, induced; molecular association, regulation MALT1(DISRUPTS) 16818229; 21199863 3 8 3 +RTN1 RTN1 Cell development/differentiation; Endoplasmic reticulum; Membrane protein, integral; Membrane protein, multi-pass Q16799 6252 14q23.1 human K772-ac 12167600 QAKIPGAkRHAE___ molecular association, regulation; acetylation apoptosis, induced DNA(DISRUPTS) 19668229 1 0 0 Inhibits histone acetylation +Csf1r CSFR EC 2.7.10.1; KINASE; Kinase, protein; Membrane protein, integral; Oncoprotein; Protein kinase, TK; Protein kinase, tyrosine (receptor) P09581 12978 18 E1|18 34.41 cM mouse Y559-p 450118 ERYEGNSyTFIDPTQ activity, induced; protein degradation; molecular association, regulation; enzymatic activity, induced; phosphorylation cell cycle regulation; transcription, induced; transcription, altered; cell differentiation, altered; apoptosis, inhibited; cell motility, altered; cytoskeletal reorganization; cell growth, altered GRB2(INDUCES); Src iso1(INDUCES); GAB2(INDUCES); CBL(INDUCES); PIK3R1(INDUCES) 10727433; 11287610; 17420255; 17420256; 18519746; 21041311 10 1 6 +SMURF2 SMURF2 EC 6.3.2.-; EC 6.3.2.19; Ligase; UBIQUITIN LIGASE; Ubiquitin conjugating system; Ubiquitin ligase Q9HAU4 64750 17q23.3-q24.1 human R234-m2 56854400 RLAERRVrSQRHRNY protein degradation 26126536 1 0 0 +WDR77 WDR77 Adaptor/scaffold; Nuclear receptor co-regulator; Transcription, coactivator/corepressor Q9BQA1 79084 1p13.2 human T5-p 471217 ___MRKEtPPPLVPP carcinogenesis, altered 20951943 1 80 72 in CCND1 T286A mutant +Rbl2 Rb-like 2 Transcription, coactivator/corepressor; Tumor suppressor Q64700 19651 8 C4|8 44.25 cM mouse K1079-ac 15207808 YFSNSPSkRLREINS intracellular localization; phosphorylation cell cycle regulation 20676144; 23029429; 35385527 3 1 0 enhances phosphorylation of Rb-like2; primes phosphorylation of itself +Cdh13 CDH13 Cell adhesion; Membrane protein, GPI anchor Q9WTR5 12554 8 E1|8 65.97 cM mouse Y327-p 486281 ETLENPKyELIIEAQ Cadherin protein degradation 17631504 1 0 0 S327F mutant is resistant to proteosomal degradataion +MYC Myc DNA-binding; Nucleolus; Oncoprotein; Transcription factor P01106 4609 8q24.21 human S363-p 466011 KCTSPRSsDTEENVK carcinogenesis, inhibited; transcription, inhibited 24030976 3 7 0 +SLBP SLBP RNA-binding Q14493 7884 4p16.3 human K156-ub 41495287 IAYDRYIkEVPRHLR SLBP_RNA_bind cell cycle regulation; RNA splicing, induced; chromatin organization, altered; cell growth, induced 27203182 1 4 0 regulation of histone mRNA processing, DNA replication during S-phase +MAGEA11 MAGE-A11 Cancer Testis Antigen (CTA); Transcription, coactivator/corepressor P43364 4110 Xq28 human K245-ub 2028409 RVKGLITkAEMLGSV MAGE protein degradation; molecular association, regulation; ubiquitination transcription, induced MAGE-A6(DISRUPTS) 23853093; 28542476 3 0 0 induce activation of E2F1; MageA6 interaction with MageA11 prevents MageA11 ubiquitination +Nfkbia IkB-alpha DNA-binding; Inhibitor Q63746 25493 6q23 rat S36-p 448204 RHDSGLDsMKDEDYE activity, induced apoptosis, altered; transcription, altered 16316997; 16407217 99 2 6 A S32A,S36A double mutant of IkBA inhibits the NFkB/p65-induced increase in dor (delta opiod receptor) promoter transcription; Cells expressing IKBa S32A S36A are more susceptible to apoptosis while in suspension than cells expressing wt IKBa. +SIAH2 SIAH2 EC 6.3.2.-; EC 6.3.2.19; Ligase; Transcription, coactivator/corepressor; UBIQUITIN LIGASE; Ubiquitin conjugating system; Ubiquitin ligase O43255 6478 3q25.1 human S28-p 471339 PQPQHTPsPAAPPAA protein degradation; molecular association, regulation; intracellular localization; enzymatic activity, induced cytoskeletal reorganization HIPK2(DISRUPTS) 19043406; 22878263; 23044042; 26751770 6 2 0 +PIK3C3 PIK3C3 Autophagy; Carbohydrate Metabolism - inositol phosphate; EC 2.7.1.137; Kinase, lipid; Motility/polarity/chemotaxis Q8NEB9 5289 18q12.3 human S249-p 35483209 ESSPILTsFELVKVP carcinogenesis, induced; autophagy, induced; cell growth, induced; apoptosis, inhibited 26118643; 33531625 2 1 0 +H3c1 H3 DNA-binding P68433 360198 13|13 A3.1 mouse K27-ac 465521 LATKAARkSAPATGG Histone phosphorylation cell cycle regulation; cell differentiation, altered; transcription, induced; transcription, altered 20561915; 25772242; 32341358; 35810562 74 18 13 transcription maintained at normal levels; MYST3 inhibits cellular senescence; DYRK1A inhibition decreases KAT6A and WDR82 phosphorylation and induces H3K27ac and H3K4me3 modi?cation, pharmacological inhibition or genetic deletion of DYRK1A promotes cardiomyocyte cell cycle activation and cardiac repair; modulated during differentiation and epigenitic reprograming +Etv4 ETV4 DNA-binding P28322 18612 11 D|11 65.48 cM mouse K138-ac 26373307 SPRQIAIkSPAPGAP ETS_PEA3_N sumoylation transcription, induced 21543453 1 1 0 acetylated sites inhibits sumoylation reciprocally +INTS11 INTS11 EC 3.1.27.-; RNA processing; Ribonuclease Q5TA45 54973 1p36.33 human K462-sm 1883375204 GISLGLLkREMAQGL molecular association, regulation; intracellular localization 36454007 1 0 0 regulates Integrator subcellular localization and interaction with integrator subunits +FANCI FANCI Cell cycle regulation; DNA repair, damage Q9NVI1 55215 15q26.1 human S556-p 11952934 VLGSLSSsQCSQSLS FANCI_HD2 molecular association, regulation; ubiquitination DNA repair, induced; cell growth, inhibited FANCD2(INDUCES); MCM5(DISRUPTS) DNA(INDUCES) 25843623; 32117957 4 2 0 prevents deubiquitination of FANCD2; inhibits dormant origin firing +Map3k7 TAK1 EC 2.7.11.25; KINASE; Kinase, protein; Protein kinase, Ser/Thr (non-receptor); Protein kinase, TKL Q62073 26409 4|4 A5 mouse S427-gl 59087900 GTEPGQVsSRSSSPS phosphorylation; enzymatic activity, induced apoptosis, inhibited; cytoskeletal reorganization 27542620 1 1 0 O-GlcNAc modi?cation TAK1 autophosphorylation ; macrophage polarization, NF-?B activation and cytokine release +CEBPB C/EBP-beta DNA-binding; Motility/polarity/chemotaxis; Transcription factor P17676 1051 20q13.13 human T235-p 447878 SSSSPPGtPSPADAK activity, induced; sumoylation; molecular association, regulation; phosphorylation cell differentiation, altered; transcription, induced; transcription, altered EHMT2 iso4(DISRUPTS); p300(INDUCES) 12213825; 16009338; 17540774; 18647749; 19723873; 21980398; 23782693; 33762327 33 11 14 +NEK6 NEK6 EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, Other; Protein kinase, Ser/Thr (non-receptor) Q9HC98 10783 9q33.3 human S206-p 448024 SETTAAHsLVGTPYY Pkinase activity, induced; enzymatic activity, induced cell growth, induced 12840024; 20595392 3 15 60 +UBQLN4 UBQLN4 Q9NRR5 56893 1q22 human S318-p 482228 GNSDSSSsQPLRTEN molecular association, regulation cell cycle regulation; DNA repair, induced MRE11A(INDUCES) 30612738 1 3 0 interaction with ubiquitinated MRE11A +SSRP1 SSRP1 Nucleolus; RNA-binding; Transcription initiation complex; Transcription, coactivator/corepressor Q08945 6749 11q12.1 human S657-p 456295 KSSSRQLsESFKSKE activity, inhibited transcription, altered 15659405 1 12 2 +CACB CACNA1C Channel, calcium; Membrane protein, integral; Membrane protein, multi-pass P15381 100101555 rabbit S1517-p 460572 DYLTRDWsILGPHHL Ion_trans activity, induced 16537462; 16820363 5 1 0 +FCRL4 FCRL4 Membrane protein, integral Q96PJ5 83417 1q23.1 human Y463-p 22730004 PKKGDLVySEIQTTQ molecular association, regulation signaling pathway regulation Ig-alpha(INDUCES) 21908428; 25972488 2 0 0 all 3 sites (Y451, Y463, Y493) inhibits BCR signaling and enhances TLR9 signaling +Cers2 LASS2 DNA-binding; Membrane protein, integral; Membrane protein, multi-pass; Transferase Q924Z4 76893 3|3 F2.1 mouse S348-p 469770 SDREETEsSEGEETA enzymatic activity, induced 26887952 1 41 179 +NFE2L2 NRF2 DNA-binding; Transcription factor Q16236 4780 2q31.2 human K518-ac 7106319 AQNCRKRkLENIVEL bZIP_Maf molecular association, regulation transcription, induced DNA(INDUCES) 19273602 1 1 0 +FZR1 FZR1 UBIQUITIN LIGASE; Ubiquitin conjugating system Q9UM11 51343 19p13.3 human S151-p 467929 DVSPYSLsPVSNKSQ protein stabilization; molecular association, regulation; activity, inhibited cell cycle regulation APC1(DISRUPTS); CDC23(DISRUPTS) 26083744; 29084198; 30498084 3 13 1 +CD81 CD81 Membrane protein, integral; Membrane protein, multi-pass P60033 975 11p15.5 human K11-ub 4666603 EGCTKCIkYLLFVFN Tetraspanin protein degradation 18713730 1 0 0 cell surface downregulation of tetraspanins +Insr INSR EC 2.7.10.1; KINASE; Kinase, protein; Membrane protein, integral; Protein kinase, TK; Protein kinase, tyrosine (receptor) P15208 16337 8 A1.1|8 1.82 cM mouse Y1179-p 447681 RDIYETDyYRKGGKG PK_Tyr_Ser-Thr cell cycle regulation; cell motility, altered 18515860 52 36 707 +Afap1l1 AFAP1L1 Unknown function Q8BZI0 106877 18|18 E1 mouse Y557-p 462143 QWPEPRIyDEVPYEK molecular association, regulation cell motility, induced; cytoskeletal reorganization NCK2(INDUCES) 26212012 1 2 4 +KLF5 KLF5 C2H2-type zinc finger protein; DNA-binding; Transcription factor Q13887 688 13q22.1 human K369-ac 458937 RSNPDLEkRRIHYCD protein degradation; protein stabilization; ubiquitination cell growth, inhibited; cell differentiation, induced; cell growth, induced; transcription, induced; transcription, inhibited; transcription, altered BAP1(DISRUPTS) 14612398; 26372456; 32685011; 35342356; 36509121 5 1 1 inhibited Basal-like breast cancer (BLBC) cell growth, and decreased KLF5 protein levels; increased KLF5 protein levels, enhanced cisplatin chemoresistance in TNBC, Inhibiting p27 transcription +XRCC4 XRCC4 DNA repair, damage Q13426 7518 5q14.2 human K296-ub 53332702 QENQLQEkENSRPDS XRCC4 ubiquitination; intracellular localization DNA repair, induced DNA(INDUCES) 26774286 1 0 0 recruitment to DNA damage sites +PKM PKM Carbohydrate Metabolism - glycolysis and gluconeogenesis; Carbohydrate Metabolism - pyruvate; EC 2.7.1.40; KINASE; Kinase, other; Mitochondrial; Nucleotide Metabolism - purine P14618 5315 15q23 human T45-p 476071 PPITARNtGIICTIG PK molecular association, regulation; enzymatic activity, inhibited; intracellular localization; phosphorylation cell cycle regulation; carcinogenesis, induced; cell growth, induced PKM iso2(DISRUPTS); MRLC2V(INDUCES) 25412762; 36198360 2 6 1 +NCL NCL DNA-binding; Helicase; Nuclear receptor co-regulator; Nucleolus; RNA-binding P19338 4691 2q37.1 human S145-p 449269 KNAKKEDsDEEEDDD intracellular localization cell cycle regulation; cell growth, induced 25313645 1 68 84 +Tbc1d4 AS160 GAP; GAP, Rab Q8BYJ6 210789 14|14 E2.3 mouse S348-p 455922 QPRRRHAsAPSHVQP PID phosphorylation 33872597 9 57 335 affects phosphorylation of other sites by AKT +Runx2 AML3 iso5 DNA-binding; Transcription factor Q08775-5 12393 17 B3|17 21.33 cM mouse S319-p 10892802 SYLSQMTsPSIHSTT activity, induced; acetylation; intracellular localization carcinogenesis, induced; cell differentiation, induced; cell motility, induced; chromatin organization, altered; transcription, induced 20484411; 22072425; 22337141; 25867060; 26206105; 27341689 11 1 0 +CDCA5 CDCA5 Cell cycle regulation Q96FF9 113130 11q13.1 human S79-p 470691 AVQSPRRsPRISFFL molecular association, regulation; activity, inhibited cell cycle regulation SCC-112(DISRUPTS); H2A.1(DISRUPTS); SMC3(DISRUPTS) 21878504; 23901111 3 18 2 +CHMP4C CHMP4C Vesicle Q96CF2 92421 8q21.13 human S214-p 1247825 ARRSRAAsSQRAEEE cell cycle regulation 22724069 2 4 8 mutations of site increase cytokinesis failure +H2ax H2AX DNA repair, damage; DNA-binding; Helicase P27661 15270 9 A5.2|9 24.84 cM mouse Y142-p 3397700 ASQASQEy_______ cell cycle regulation; DNA repair, induced; chromatin organization, altered; apoptosis, induced; apoptosis, inhibited 31902729; 34330317 10 2 2 +Trex1 TREX1 Cell cycle regulation; DNA repair, damage; DNA-binding; Deoxyribonuclease; EC 3.1.11.2 Q91XB0 22040 9|9 F2 mouse S261-p 2579810 PLATANGsPSNGRSR transcription, altered RPN1(DISRUPTS) 28297665 1 7 0 +RSF1 HBXAP Transcription, coactivator/corepressor Q96T23 51773 11q14.1 human S1359-p 3072999 ENVGKVGsPLDYSLV cell cycle regulation 26259146 1 46 6 plays a role in PLK1 recruitment and deposition on mitotic kinetochores +AKTIP AKTIP Apoptosis; Membrane protein, peripheral; Vesicle Q9H8T0 64400 16q12.2 human T190-p 20797700 RVFYKIDtASPLNPE UQ_con receptor internalization, induced; intracellular localization; phosphorylation endocytosis, induced 21777610 1 0 0 enhanced phosphorylation of JNK, p38 and EGFR +Ptpn11 SHP-2 EC 3.1.3.48; Motility/polarity/chemotaxis; PHOSPHATASE; Protein phosphatase, tyrosine (non-receptor) P35235 19247 5|5 F mouse Y580-p 448493 REDSARVyENVGLMQ molecular association, regulation; phosphorylation; enzymatic activity, induced GRB2(INDUCES) 11779868; 18827006 18 60 1189 ERK phosphorylation/activation +ERG ERG DNA-binding; Oncoprotein; Transcription factor P11308 2078 21q22.2 human K92-ac 56394101 CSVAKGGkMVGSPDT molecular association, regulation carcinogenesis, induced; transcription, induced BRD4(INDUCES) 27223260 3 1 0 +CERS2 LASS2 DNA-binding; Membrane protein, integral; Membrane protein, multi-pass; Transferase Q96G23 29956 1q21.3 human S348-p 469770 SDREETEsSEGEEAA enzymatic activity, induced 26887952 1 41 179 +MT-CO1 COX1 EC 1.9.3.1; Energy Metabolism - oxidative phosphorylation; Membrane protein, integral; Membrane protein, multi-pass; Mitochondrial; Oxidoreductase P00395 4512 - human K319-ac 1879877104 IAIPTGVkVFSWLAT apoptosis, induced 31647884 1 0 0 mutant sites were found to significantly suppressed the AAPH-evoked increase in both ROS level and apoptosis +HMOX1 HMOX1 Cofactor and Vitamin Metabolism - porphyrin and chlorophyll; EC 1.14.99.3; Oxidoreductase P09601 3162 22q12.3 human K256-ac 206219704 PVETPRGkPPLNTRS molecular association, regulation carcinogenesis, induced; cell motility, induced; cell growth, induced JunD(INDUCES) 28846111 1 1 0 Interaction leads to AP-1 transcriptional activation +NEK9 NEK9 Autophagy; EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, Other; Protein kinase, Ser/Thr (non-receptor) Q8TD19 91754 14q24.3 human T210-p 451116 SEYSMAEtLVGTPYY Pkinase enzymatic activity, induced cell cycle regulation 14660563; 16079175; 21642957 4 0 0 +GCSAM GCET2 Unknown function Q8N6F7 257144 3q13.2 human Y148-p 463675 ARSPEDEyELLMPHR HGAL activity, induced cell motility, altered; signaling pathway regulation MYO3A(INDUCES); MYO5B(INDUCES) 17823310; 31362927 2 6 179 regulates B cell receptor signaling +ABL1 Abl EC 2.7.10.2; KINASE; Kinase, protein; Oncoprotein; Protein kinase, TK; Protein kinase, tyrosine (non-receptor) P00519 25 9q34.12 human Y232-p 450302 VYGVSPNyDKWEMER intracellular localization; protein conformation 21347248 3 6 255 +BORA BORA Activator Q6PGQ7 79866 13q21.33 human S274-p 9318308 TSPSPISsPTFSPIE protein degradation; molecular association, regulation cell cycle regulation PIN1(INDUCES) 23442801; 23970419 2 2 0 required for mitotic entry +EIF2AK2 PKR EC 2.7.10.2; EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, Other; Protein kinase, Ser/Thr (non-receptor); Protein kinase, tyrosine (non-receptor); Translation P19525 5610 2p22.2 human Y101-p 458271 EGLSMGNyIGLINRI dsrm enzymatic activity, induced translation, altered; cell growth, altered 16373505 1 1 0 +EGFR EGFR EC 2.7.10.1; KINASE; Kinase, protein; Membrane protein, integral; Oncoprotein; Protein kinase, TK; Protein kinase, tyrosine (receptor) P00533 1956 7p11.2 human K1188-ac 14991105 AKPNGIFkGSTAENA receptor internalization, induced; phosphorylation endocytosis, induced; signaling pathway regulation 20513767 1 1 0 induces AKT phosphorylation and hence ERK1/2 signaling +ORC2 ORC2 DNA replication Q13416 4999 2q33.1 human S188-p 21507302 SEYSASNsEDDEGVA cell cycle regulation; carcinogenesis, induced; apoptosis, inhibited; transcription, induced 21947279; 23188630 2 0 0 +KCNQ1 Kv7.1 Channel, potassium; Membrane protein, integral; Membrane protein, multi-pass P51787 3784 11p15.5-p15.4 human S27-p 2999203 LPGARRGsAGLAKKC activity, induced; molecular association, regulation; protein conformation KCNE1(INDUCES) 12835205; 22095730; 25037568 4 2 0 cAMP-mediated upregulation of channel IKS K+ current +GRIA1 GluR1 Channel, calcium; Channel, ligand-gated; Membrane protein, integral; Membrane protein, multi-pass P42261 2890 5q33.2 human S849-p 448565 FCLIPQQsINEAIRT activity, induced 18305116 94 4 3 enhanced GluR1 currents +TACC3 TACC3 Cell cycle regulation Q9Y6A5 10460 4p16.3 human S558-p 474537 ESALRKQsLYLKFDP molecular association, regulation; intracellular localization cell cycle regulation; carcinogenesis, induced; autophagy, induced; cell growth, induced; cytoskeletal reorganization CLTC(INDUCES); CLTA(INDUCES) 17545617; 21297582; 31932847; 33805672; 36221072 12 15 43 +MYC Myc DNA-binding; Nucleolus; Oncoprotein; Transcription factor P01106 4609 8q24.21 human K290-ac 458886 EKRQAPGkRSESGSP Myc_N molecular association, regulation ZBTB17(INDUCES) 16126174 2 2 0 induces association with ZBTB17 on specific target promoters +RACK1 RACK1 Adaptor/scaffold; G protein; G protein, heterotrimeric; G protein, heterotrimeric beta; Motility/polarity/chemotaxis; Nuclear receptor co-regulator P63244 10399 5q35.3 human S63-p 56567300 QRALRGHsHFVSDVV WD40 molecular association, regulation autophagy, induced ATG5(INDUCES) 27325703 1 1 0 +P2RY1 P2RY1 GPCR, family 1; Membrane protein, integral; Membrane protein, multi-pass; Receptor, GPCR P47900 5028 3q25.2 human S354-p 1985600 EANLQSKsEDMTLNI receptor internalization, altered 21108629 1 2 0 +Sh2b2 APS Adaptor/scaffold Q9Z200 114203 12q12 rat Y618-p 448842 ARAVENQySFY____ molecular association, regulation Cbl-c(INDUCES) 11997497 2 3 5 +ANGPTL8 EG624219 Secreted; Secreted, signal peptide Q6UXH0 55908 19p13.2 human S94-p 1869062301 AAQELRAsLLETQME phosphorylation 32344005 1 0 0 enhances Akt phosphorylation, regulates signaling pathway AKT-GSK3 ?/-FoxO1 through Akt phosphorylation +KIF23 KIF23 iso2 Microtubule-binding; Motility/polarity/chemotaxis; Motor Q02241-2 9493 15q23 human S710-p 470674 LRHRRSRsAGDRWVD MKLP1_Arf_bdg molecular association, regulation cell cycle regulation 14-3-3 zeta(INDUCES); 14-3-3 gamma(INDUCES) 20451386 5 7 0 +Mok MOK EC 2.7.11.22; KINASE; Kinase, protein; Protein kinase, CMGC; Protein kinase, Ser/Thr (non-receptor) Q9WVS4 26448 12|12 F1 mouse T159-p 450005 VYSKQPYtEYISTRW Pkinase activity, induced 10421840 1 1 0 While the authors did not prove that these sites were phosphorylated, mutation of both T159 and Y161, located in the activation loop, abolished the enzymatic activity of the kinase. +NCOA2 SRC-2 Motility/polarity/chemotaxis; Nuclear receptor co-regulator; Transcription, coactivator/corepressor Q15596 10499 8q13.3 human S469-p 4728825 NYALKMNsPSQSSPG NCOA_u2 transcription, induced 22158970 2 6 3 +PML PML Nucleolus; Oncoprotein; SUMO LIGASE; SUMO conjugating system; SUMO ligase; Transcription factor; Tumor suppressor; Ubiquitin conjugating system P29590 5371 15q24.1 human S562-p 6835502 RVVVISSsEDSDAEN DUF3583 molecular association, regulation SUMO2(INDUCES); SUMO1(INDUCES); SUMO3(INDUCES) 19217413; 19380586 2 6 0 PML interaction with SUMO-modified protein partners and PML nuclear bodies maturation +EIF2AK2 PKR EC 2.7.10.2; EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, Other; Protein kinase, Ser/Thr (non-receptor); Protein kinase, tyrosine (non-receptor); Translation P19525 5610 2p22.2 human T258-p 448087 DMKETKYtVDKRFGM enzymatic activity, induced 11152499; 9528799 2 0 0 +PAK6 PAK6 EC 2.7.11.1; KINASE; Kinase, protein; Nuclear receptor co-regulator; Protein kinase, STE; Protein kinase, Ser/Thr (non-receptor) Q9NQU5 56924 15q15.1 human T354-p 29666303 SPAGSPRtWHAQIST molecular association, regulation; enzymatic activity, induced carcinogenesis, induced; cell motility, induced AR(INDUCES) 24130878 1 1 0 promotion of cell motility and invasion +MEF2C MEF2C iso3 DNA-binding; Transcription factor Q06413-3 4208 5q14.3 human T293-p 448000 QSAQSLAtPVVSVAT activity, induced transcription, altered 9069290 2 0 0 +Ern1 IRE1 Apoptosis; Chaperone; EC 2.7.11.1; Endoplasmic reticulum; KINASE; Kinase, protein; Membrane protein, integral; Protein kinase, Other; Protein kinase, Ser/Thr (non-receptor); Ribonuclease Q9EQY0 78943 11|11 E1 mouse S724-p 7161100 KLAVGRHsFSRRSGV Pkinase phosphorylation; enzymatic activity, induced RNA splicing, induced; RNA splicing, altered; apoptosis, induced; transcription, induced; transcription, altered 21911379; 26306048; 33610548; 35500653; 35863429 18 2 0 +PRKACA PKACA EC 2.7.11.11; KINASE; Kinase, protein; Protein kinase, AGC; Protein kinase, Ser/Thr (non-receptor) P17612 5566 19p13.12 human Y70-p 1269647501 HKETGNHyAMKILDK Pkinase molecular association, regulation; intracellular localization; enzymatic activity, induced cytoskeletal reorganization LARP2(INDUCES); AKAP9(INDUCES); AKAP5(DISRUPTS); CDK5RAP2(INDUCES); PDE4DIP(INDUCES); LARP(INDUCES); ANXA1(INDUCES) 30274258 1 1 0 +Pde3a PDE3A EC 3.1.4.17; Membrane protein, integral; Membrane protein, multi-pass; Nucleotide Metabolism - purine; Phosphodiesterase Q9Z0X4 54611 6|6 G2 mouse S290-p 471415 GWKRRRRsSSVVAGE enzymatic activity, induced 17124499 2 2 9 activated during oocytes maturation in mouse treated with hCG ; required for insulin-dependent Xenopus oocyte maturation +HSF1 HSF1 DNA-binding; Transcription factor Q00613 3297 8q24.3 human S319-p 455483 EASPGRPsSVDTLLS Vert_HS_TF transcription, inhibited 25963659 2 8 0 under non-stressed conditions, upon heat shock S to A mutant showed 60% higher luciferase activity +H4C1 H4 DNA-binding P62805 8359 6p22.2 human K20-m3 2344825 GGAKRHRkVLRDNIQ CENP-T_C molecular association, regulation; acetylation cell cycle regulation; carcinogenesis, induced; chromatin organization, altered; transcription, altered; transcription, inhibited JMJD2A(INDUCES) 17237781; 17967882; 18470998; 18794842; 19706462; 19935671; 20053926 35 14 0 +WRN WRN Cell cycle regulation; DNA repair, damage; DNA-binding; EC 3.6.4.12; Helicase; Nucleolus Q14191 7486 8p12 human K496-sm 12004439 PTHSKCLkMERNLGL intracellular localization 15355988 1 1 0 +CCNT1 CCNT1 Cell cycle regulation; Transcription initiation complex O60563 904 12q13.11-q13.12 human S564-p 28735106 KTYSLSSsFSSSSST enzymatic activity, inhibited transcription, inhibited 23977272 1 4 0 inhibits the kinase activity of cyclin T1/Cdk9 complex +Stmn2 STMN2 Cytoskeletal P21818 84510 2q23 rat S62-p 450174 ELILKPPsPISEAPR Stathmin cytoskeletal reorganization 9525956 9 11 0 +DIABLO DIABLO Apoptosis; Mitochondrial Q9NR28 56616 12q24.31 human S67-p 29431803 AQKSEPHsLSSEALM Smac_DIABLO molecular association, regulation apoptosis, induced XIAP(INDUCES) 24038446 1 2 0 +FBXL2 FBXL2 UBIQUITIN LIGASE; Ubiquitin ligase Q9UKC9 25827 3p22.3 human K201-ub 28058800 QLEDEALkHIQNYCH protein degradation 23542741 1 0 0 +Eps8 EPS8 Adaptor/scaffold Q08509 13860 6 G1|6 66.78 cM mouse Y524-p 457963 NHQVDRNyDAVKTQP phosphorylation carcinogenesis, induced; cell motility, induced; cell growth, induced; cell adhesion, induced 28214294 3 20 399 enhanced phosphorylation of ERK and FAK, increased cell adhesion and anchorage-dependent colony formation +SLC9A1 NHE1 Membrane protein, integral; Membrane protein, multi-pass; Motility/polarity/chemotaxis; Transporter; Transporter, SLC family P19634 6548 1p36.11 human S726-p 2509107 IDPASPQsPESVDLV activity, induced apoptosis, induced 18701649 4 11 3 regulates the apoptotic alkalinizing activity of NHE1 +CCP110 CP110 Cell cycle regulation O43303 9738 16p12.3 human S45-p 35546003 FHGVAILsPLLNIEK CaM_bind intracellular localization cell cycle regulation 12361598 1 4 0 +NHE-3 NHE3 Membrane protein, integral; Membrane protein, multi-pass; Transporter; Transporter, SLC family P26432 100009430 rabbit S663-p 457469 TMRKRLEsFKSAKLG activity, induced; intracellular localization; activity, inhibited 15888551; 25480791 4 1 2 decreased surface expression of NHE3, phosphorylation of this site with other 2 sites are together necessary for activity inhibition; Dexamthasone increases NHE-3 on the membrane surface in wild-type but not in S663A mutant. ; dexamethasone stimulates activity +MCAM MCAM Cell adhesion; Membrane protein, integral P43121 4162 11q23.3 human Y641-p 458525 PGDQGEKyIDLRH__ molecular association, regulation; phosphorylation cell growth, induced; apoptosis, inhibited; signaling pathway regulation RICTOR(INDUCES) 31665642 1 5 79 complex formation inhibits ubiquitination, induces AKT phosphorylation, induces mTORC2 signaling +DGCR8 DGCR8 Nucleolus; RNA processing; RNA-binding Q8WYQ5 54487 22q11.21 human K259-sm 57676500 EEGLCAPkKRRTEEK intracellular localization carcinogenesis, inhibited; cell growth, inhibited 27436753 1 0 0 +Creb1 CREB iso1 DNA-binding; Transcription factor P15337-1 81646 9q32 rat S111-p 451808 TIAESEDsQESVDSV transcription, altered 9931297 9 3 3 +Oprm1 MOR-1 GPCR, family 1; Membrane protein, integral; Membrane protein, multi-pass; Receptor, GPCR P42866 18390 10 A1|10 1.85 cM mouse T394-p 448128 LENLEAEtAPLP___ receptor internalization, induced; receptor desensitization, induced 27707973 5 0 0 tolerance in both opioid analgesia and opioid reward +YAP1 YAP1 Oncoprotein; Transcription, coactivator/corepressor P46937 10413 11q22.1 human Y407-p 473004 SGLSMSSySVPRTPD protein degradation; molecular association, regulation; protein stabilization; ubiquitination; intracellular localization; activity, inhibited carcinogenesis, induced; carcinogenesis, inhibited; cell motility, induced; cell growth, inhibited; apoptosis, induced; transcription, induced; cell motility, inhibited; cell growth, induced; apoptosis, inhibited; transcription, inhibited SIAH1(INDUCES); p73(INDUCES) DNA(DISRUPTS) 18280240; 18701449; 25361080; 26549256; 32205868; 35041461; 35713503; 35723276; 35999654 23 3 4 +PRKCD PKCD EC 2.7.11.13; KINASE; Kinase, protein; Nuclear receptor co-regulator; Protein kinase, AGC; Protein kinase, Ser/Thr (non-receptor); Protein kinase, tyrosine (non-receptor); Tumor suppressor Q05655 5580 3p21.1 human Y374-p 464424 ELKGRGEyFAIKALK Pkinase protein stabilization; receptor recycling, induced; intracellular localization; enzymatic activity, induced carcinogenesis, induced; cell growth, induced; signaling pathway regulation 33411917 3 18 531 prevents EGFR degradation and induces its recycling, induces EGFR signaling, induces RTK activation +MAP9 MAP9 Cell cycle regulation Q49MG5 79884 4q32.1 human S289-p 15105800 SDENKENsFSADHVT cell cycle regulation 20615875 1 2 0 required for centrosome integrity during mitosis +RRN3 TIF1A Nucleolus; Transcription initiation complex Q9NYV6 54700 16p13.11 human S44-p 470000 LENDFFNsPPRKTVR activity, induced transcription, altered 15004009 2 25 9 +NEDD4L NEDD4L EC 6.3.2.-; EC 6.3.2.19; Ligase; UBIQUITIN LIGASE; Ubiquitin conjugating system; Ubiquitin ligase Q96PU5 23327 18q21.31 human T903-p 125971701 IRLLQFVtGTSRVPM HECT ubiquitination endocytosis, induced 28588583 1 0 0 +MCM3 MCM3 DNA replication; EC 3.6.4.12 P25205 4172 6p12.2 human T722-p 449197 EEMPQVHtPKTADSQ molecular association, regulation cell cycle regulation DNA(INDUCES) 21965652 2 65 62 T722 phosphorylation affects MCM3 loading onto chromatin, and MCM3 overexpression blocks S phase entry. +L1cam NCAM-L1 Cell adhesion; Membrane protein, integral Q05695 50687 Xq37 rat Y1153-p 466002 KRSKGGKySVKDKED Bravo_FIGEY molecular association, regulation; intracellular localization Ezrin(DISRUPTS) 18478542 2 0 0 +ANXA1 ANXA1 Calcium-binding; Lipid-binding P04083 301 9q21.13 human S28-p 452053 YVQTVKSsKGGPGSA intracellular localization 19428336 2 0 0 +CARD9 CARD9 Adaptor/scaffold Q9H257 64170 9q34.3 human T231-p 23017301 CKVERKHtLKLRHAM molecular association, regulation; phosphorylation signaling pathway regulation Bcl-10(INDUCES) 22265677 1 0 0 induces TAK1 phosphorylation and Dectin1 signaling +PRC1 PRC1 Cell cycle regulation; Cytoskeletal; Microtubule-binding; Motility/polarity/chemotaxis O43663 9055 15q26.1 human T616-p 7444691 TSGILNStNIQS___ molecular association, regulation cell cycle regulation; chromatin organization, altered; cytoskeletal reorganization PLK1(INDUCES) 17351640; 22621898; 23940115; 24120663 4 5 0 Dephosphorylation at T481 and phosphorylation at T616 lead to mitotic exit +NOTCH1 Notch 1 Membrane protein, integral; Motility/polarity/chemotaxis; Oncoprotein; Receptor, misc.; Transcription factor P46531 4851 9q34.3 human K2164-ac 18899513 KVRKPSSkGLACGSK intracellular localization cell growth, induced; apoptosis, inhibited 28377411 2 1 0 +GSTP1 GSTP1 EC 2.5.1.18; Other Amino Acids Metabolism - glutathione; Transferase; Xenobiotic Metabolism - drug metabolism - cytochrome P450; Xenobiotic Metabolism - metabolism by cytochrome P450 P09211 2950 11q13.2 human Y8-p 459294 MPPYTVVyFPVRGRC GST_N protein conformation; enzymatic activity, induced 19254954 2 18 233 +OPRL1 KOR-3 GPCR, family 1; Membrane protein, integral; Membrane protein, multi-pass; Receptor, GPCR P41146 4987 20q13.33 human S346-p 1868135700 LRRDVQVsDRVRSIA receptor internalization, induced; receptor desensitization, induced signaling pathway regulation 30914485 1 0 0 +KIF2C KIF2C Cancer Testis Antigen (CTA); Microtubule-binding; Motility/polarity/chemotaxis; Motor Q99661 11004 1p34.1 human S715-p 3545002 MQLEEQAsRQISSKK molecular association, regulation; enzymatic activity, induced 26206521 2 0 0 improves its MT-binding affinity, stimulates its MT depolymerization activity, accurate chromosome segregation +CHEK1 Chk1 EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, CAMK; Protein kinase, Ser/Thr (non-receptor); Tumor suppressor O14757 1111 11q24.2 human S286-p 465527 TSGGVSEsPSGFSKH intracellular localization cell cycle regulation 18983824; 21907702 5 12 14 +Wasl N-WASP Adaptor/scaffold; Motility/polarity/chemotaxis O08816 682507 4q22 rat S481-p 3149547 RSKAIHSsDEDEDDD endocytosis, induced; cytoskeletal reorganization 21610097 3 19 1 Phosphorylation induces CK2-A1 and N-WASP complex formation and regulate cell surface EGFR levels by endocytosis. Phosphorylation reduces actin polymerization. +Add1 ADD1 Cytoskeletal; Motility/polarity/chemotaxis Q9QYC0 11518 5 B2|5 17.9 cM mouse S436-p 451595 TCSPLRHsFQKQQRE intracellular localization 25344630 2 21 9 colocalized with astrocyte protein GFAP in the spinal cord +Ncoa2 SRC-2 Motility/polarity/chemotaxis; Nuclear receptor co-regulator; Transcription, coactivator/corepressor Q61026 17978 1 A3|1 4.12 cM mouse S736-p 465446 TVKQEPAsPKKKENA DUF4927 transcription, induced 16410316 4 20 10 stimulates ER-mediated transcription and proliferation +VAMP8 VAMP8 Membrane protein, integral; Vesicle Q9BV40 8673 2p11.2 human T54-p 5434062 KTEDLEAtSEHFKTT Synaptobrevin activity, inhibited 27402227 1 16 16 abolish function in SNARE complex during mast cell secretion, reduces in vitro ensemble vesicle fusion +IRS1 IRS1 Adaptor/scaffold; Motility/polarity/chemotaxis P35568 3667 2q36.3 human S636-p 447506 SGDYMPMsPKSVSAP intracellular localization carcinogenesis, induced; cell motility, induced 16914728; 27014871 41 26 1 +Nkx3-1 NKX3-1 DNA-binding; Transcription factor; Tumor suppressor P97436 18095 14 D2|14 36.02 cM mouse S186-p 4825101 KTKRKQLsEDLGVLE protein degradation carcinogenesis, induced; cell growth, induced; DNA repair, inhibited 32943441 5 3 0 +H4c2 H4 DNA-binding P62806 326620 13|13 A3.1 mouse K5-ac 458958 ___SGRGkGGKGLGK transcription, induced 17344422 72 22 516 +MCC MCC Cell cycle regulation; Tumor suppressor P23508 4163 5q22.2 human S120-p 3624826 LRSELSQsQHEVNED activity, induced cell cycle regulation 21779472 1 9 2 +PRKCI PKCI Cell adhesion; Cell development/differentiation; EC 2.7.11.13; KINASE; Kinase, protein; Motility/polarity/chemotaxis; Oncoprotein; Protein kinase, AGC; Protein kinase, Ser/Thr (non-receptor); Tumor suppressor P41743 5584 3q26.2 human T564-p 2839109 TNEPVQLtPDDDDIV Pkinase_C signaling pathway regulation 23511975 7 24 6 signaling for synaptic incorporation of AMPAR at activated synapses during LTP expression +RPS3 RPS3 Apoptosis; EC 4.2.99.18; RNA-binding; Ribosomal; Translation P23396 6188 11q13.4 human K214-sm 25218900 HVSIVEPkDEILPTT protein stabilization 21968017 1 1 0 +FANCD2 FANCD2 DNA repair, damage Q9BXW9 2177 3p25.3 human S222-p 447816 LPEILGDsQHADVGK FancD2 cell cycle regulation 12086603 3 2 0 Phosphorylation of FANCD2 on S222 is required for the IR-inducible S phase checkpoint but not the G1/S or G2/M checkpoints +Smad4 SMAD4 DNA-binding; Nuclear receptor co-regulator; Transcription, coactivator/corepressor P97471 17128 18 E2|18 49.51 cM mouse K158-sm 2793925 NAPSMLVkDEYVHDF neural plasticity; transcription, induced 29183317 8 1 0 induces spatial learning and memory +LOXL3 LOXL3 EC 1.4.3.-; Oxidoreductase; Secreted; Secreted, signal peptide P58215 84695 2p13.1 human S704-p 1881957100 PNFEVAEsDFTNNAM molecular association, regulation; enzymatic activity, induced carcinogenesis, induced; signaling pathway regulation DHODH(INDUCES) 37253718 1 1 0 prevents DHODH ubiquitination, regulates the AK2?LOXL3?DHODH pathway +MKNK2 Mnk2 EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, CAMK; Protein kinase, Ser/Thr (non-receptor); Translation Q9HBH9 2872 19p13.3 human S74-p 456328 KRGRATDsFSGRFED molecular association, regulation; enzymatic activity, inhibited carcinogenesis, inhibited ELF4(DISRUPTS) 32170339 1 11 3 +Pcdhga3 PCDHGA3 Cell adhesion; Membrane protein, integral Q91XY5 93711 18|18 B3 mouse S922-p 41590812 GNGNKKKsGKKEKK_ Cadherin_tail cytoskeletal reorganization 26139604 1 0 0 S922 phosphorylation decreases dendrite arborization. +TRIOBP Tara iso5 Actin-binding; Cytoskeletal; Motility/polarity/chemotaxis Q9H2D6-5 11078 22q13.1 human T221-p 33365503 RRKWFEAtDSRTPEV molecular association, regulation; intracellular localization TRF1(DISRUPTS) 24692559 1 1 0 required for dissociation of telomeric TRF1 at prophase or early prometaphase +EEF1A2 EEF1A2 Translation; Translation elongation Q05639 1917 20q13.33 human K55-m1 8106722 EMGKGSFkYAWVLDK GTP_EFTU molecular association, regulation L3MBTL iso4(INDUCES) 23583077 0 3 46 +AHR AHR DNA-binding; Transcription factor P35869 196 7p21.1 human S440-p 1874101918 NGTSGKDsATTSTLS protein degradation; ubiquitination autophagy, induced; transcription, induced 34198826 1 0 0 +FGFR2 FGFR2 EC 2.7.10.1; KINASE; Kinase, protein; Membrane protein, integral; Oncoprotein; Protein kinase, TK; Protein kinase, tyrosine (receptor) P21802 2263 10q26.13 human S780-p 34500854 SQPLEQYsPSYPDTR phosphorylation carcinogenesis, inhibited; cell motility, inhibited; signaling pathway regulation 31146385 1 1 0 inhibits tyrosine phosphorylation of FGFR2 and phosphorylatin of ERK1/2 and PLC, inhibits the Ras/MAPK pathway +VGLL4 VGLL4 iso4 Transcription, coactivator/corepressor Q14135-4 9686 3p25.3-p25.2 human T159-p 3195944 AGLSPTLtPGERQQN VGLL4 cell cycle regulation; cell growth, induced 28739871 1 6 1 Mitotic phosphorylation +DDIT3 DDIT3 Autophagy; DNA-binding; Oncoprotein; Transcription factor P35638 1649 12q13.3 human S79-p 448090 EVTSTSQsPHSPDSS transcription, altered 8650547 1 1 0 CHOP-Gal-4 chimeric protein induced a reporter gene expression. +H2BC3 H2B DNA-binding P33778 3018 6p22.2 human K12-ac 458956 KSAPAPKkGSKKAIT Histone transcription, altered 16283522 7 12 467 +DYNLT1 DYNLT1 Microtubule-binding; Motility/polarity/chemotaxis; Motor P63172 6993 6q25.3 human T94-p 456225 SSTDGSCtVRWENKT Tctex-1 activity, induced; molecular association, regulation; intracellular localization cell cycle regulation; cell differentiation, induced; cell growth, induced; cytoskeletal reorganization TIM-1(DISRUPTS) 21394082; 23954591; 29693725 7 0 0 T94 phosphorylation promotes proliferation of neural progenitors through modulation of ciliary resorption and G1 length. +DAXX DAXX Apoptosis; Nuclear receptor co-regulator; Nucleolus; Transcription, coactivator/corepressor Q9UER7 1616 6p21.32 human S668-p 448623 KKICTLPsPPSPLAS activity, induced; molecular association, regulation; intracellular localization; phosphorylation transcription, induced; signaling pathway regulation Exportin-1(INDUCES) 12968034; 15128734; 22199361; 23260419 4 15 0 activates c-Jun phosphorylation, increases SF1 activity, increases CYP11A1 expression in steroidogenesis; necrotic cell death induced +tpx2.L TPX2 Cell cycle regulation; Microtubule-binding Q6NUF4 398174 frog S281-p 460756 VPKPFNLsKGKRKHE intracellular localization KPNB1(INDUCES) 29276125 1 9 23 accumulation of TPX2 at the prophase centrosome +ARHGDIA RhoGDI alpha Apoptosis; Cell adhesion; Cell development/differentiation; G protein regulator, misc.; Motility/polarity/chemotaxis P52565 396 17q25.3 human S34-p 467490 YKPPAQKsIQEIQEL Rho_GDI molecular association, regulation cell adhesion, altered RHOA(DISRUPTS) 20472934; 34133221 5 28 0 +IKBKE IKKE EC 2.7.11.10; Inhibitor; KINASE; Kinase, protein; Protein kinase, Other; Protein kinase, Ser/Thr (non-receptor) Q14164 9641 1q32.1 human K231-sm 13258715 FGGPRRNkEIMYRIT Pkinase intracellular localization; phosphorylation apoptosis, inhibited; transcription, induced 20188669 1 0 0 induces NF-kB phosphorylation +Gria2 GluR2 Channel, calcium; Channel, ligand-gated; Membrane protein, integral; Membrane protein, multi-pass P19491 29627 2q33 rat Y869-p 476831 NSQNFATyKEGYNVY receptor internalization, induced 14976558 3 1 4 long-term depression of AMPA receptor-mediated excitatory postsynaptic currents +OTUB1 OTUB1 DEUBIQUITINASE; EC 3.4.19.12; Protease; Ubiquitin conjugating system; Ubiquitin-specific protease Q96FW1 55611 11q13.1 human S16-p 3208998 QKQEPLGsDSEGVNC ubiquitination; intracellular localization DNA repair, induced; carcinogenesis, inhibited; apoptosis, induced; transcription, induced 25872870; 34785775 3 14 0 nuclear localization, S16A mutant cytoplasmic localzation and impaired foci formation after IR; induces p53 deubiquitination and stabilization +CTBP1 CTBP1 iso2 Cell cycle regulation; EC 1.1.1.-; Nuclear receptor co-regulator; Oxidoreductase; Transcription, coactivator/corepressor Q13363-2 1487 4p16.3 human S147-p 455351 REGTRVQsVEQIREV 2-Hacid_dh; 2-Hacid_dh_C intracellular localization endocytosis, induced 18323776 7 2 0 facilitates infectious entry of Ad3 (virus), cytoplasmic localization +CDC25A CDC25A EC 3.1.3.48; Motility/polarity/chemotaxis; PHOSPHATASE; Protein phosphatase, dual-specificity P30304 993 3p21.31 human S40-p 63080405 ASAAGGLsPVTNLTV protein degradation cell cycle regulation 28192398 1 1 0 +Gria1 GluR1 Channel, calcium; Channel, ligand-gated; Membrane protein, integral; Membrane protein, multi-pass P19490 50592 10q22 rat K886-ac 206219720 VVSQDFPkSMQSIPC protein stabilization; ubiquitination; receptor internalization, inhibited neural plasticity 28793258 1 0 0 inhibits ubiquitination; impaired learning and memory +WBP2 WBP2 Cell development/differentiation; Nuclear receptor co-regulator Q969T9 23558 17q25.1 human K222-ub 58948901 STPAAEAkAAEAAAS protein degradation carcinogenesis, inhibited; cell growth, inhibited; transcription, inhibited 27578003 2 2 0 in vitro transformation inhibited +Tgif1 TGIF DNA-binding; Nuclear receptor co-regulator; Transcription, coactivator/corepressor P70284 21815 17|17 E1.3 mouse T235-p 1868546604 PQSGLFNtPPPTPPD molecular association, regulation carcinogenesis, induced; cell growth, induced; transcription, induced; signaling pathway regulation TWIST1(INDUCES); TWIST1(DISRUPTS) 31152009; 31268604 2 0 0 TGIF T239D/T235D mutant does not inhibit TWIST1 expression; in Kras active mutant cells; TGIF T239D/T235D mutant stimulates proliferation of Capan-2 cells +SCN1A SCN1A Channel, sodium; Membrane protein, integral; Membrane protein, multi-pass P35498 6323 2q24.3 human T1934-p 1239966003 RRHLLKRtVKQASFT molecular association, regulation Calmodulin(INDUCES) 30142967 1 0 0 +CD40 CD40 Membrane protein, integral; Receptor, cytokine P25942 958 20q13.12 human T254-p 451275 TAAPVQEtLHGCQPV activity, induced; molecular association, regulation TRAF2(INDUCES) 12133933; 1696597 2 0 0 T254 phosphorylation results in growth inhibition of M12/CD40+ cells. +PTPRA PTPRA iso6 EC 3.1.3.48; Membrane protein, integral; Motility/polarity/chemotaxis; PHOSPHATASE; Receptor protein phosphatase, tyrosine P18433-2 5786 20p13 human S180-p 447611 QAGSHSNsFRLSNGR molecular association, regulation; phosphorylation; enzymatic activity, induced cell growth, altered PIK3CB(INDUCES); Src(INDUCES); PKCD(INDUCES); GRB2(DISRUPTS) 11676480; 11923305; 23532252 6 17 0 promotes PTPRA tyrosine phosphorylation +Rps6ka3 RSK2 EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, AGC; Protein kinase, Ser/Thr (non-receptor) P18654 110651 X F4|X 73.27 cM mouse T365-p 450151 DPEFTAKtPKDSPGI Pkinase_C enzymatic activity, induced 10856237 6 36 14 +PIAS1 PIAS1 EC 6.3.2.-; Nuclear receptor co-regulator; SUMO LIGASE; SUMO conjugating system; SUMO ligase; Transcription, coactivator/corepressor O75925 8554 15q23 human S17-p 53747701 MVMSLRVsELQVLLG protein degradation; molecular association, regulation translation, inhibited HECTD2(INDUCES) 26157031 1 0 0 +KIF14 KIF14 Microtubule-binding; Motor Q15058 9928 1q32.1 human S1220-p 114810404 NLHSSHSsGLMDKSS intracellular localization 28630147 1 0 0 spindle localization of Kif14 in anaphase +Gja1 GJA1 Channel, misc.; Membrane protein, integral; Membrane protein, multi-pass; Motility/polarity/chemotaxis P23242 14609 10 B4|10 28.64 cM mouse S330-p 449994 AGSTISNsHAQPFDF Connexin43 molecular association, regulation; intracellular localization cytoskeletal reorganization; signaling pathway regulation; endocytosis, inhibited ERK1(DISRUPTS); TUBB(INDUCES) 16882687; 21527737; 31189653; 36206047 10 14 0 +CXCR2 IL8RB GPCR, family 1; Membrane protein, integral; Membrane protein, multi-pass; Receptor, GPCR; Receptor, cytokine P25025 3579 2q35 human S353-p 451049 PSFVGSSsGHTSTTL protein degradation; receptor desensitization, altered; receptor internalization, altered 9079638 1 0 0 +Cidec CIDEC Apoptosis P56198 14311 6|6 E3 mouse K224-ub 12718506 TEEEQPAkAKPSSLL protein degradation 20089860 1 0 0 +MAPK15 ERK7 EC 2.7.11.24; KINASE; Kinase, protein; Protein kinase, CMGC; Protein kinase, Ser/Thr (non-receptor) Q8TD08 225689 8q24.3 human Y177-p 459217 EDQAVTEyVATRWYR Pkinase enzymatic activity, induced apoptosis, induced 16336213; 16484222; 28467781 3 5 23 +Bach2 BACH2 DNA-binding; Transcription factor P97303 12014 4|4 A5 mouse S520-p 470117 ETRTRTSsSCSSYSY activity, induced; intracellular localization translation, induced 27158840 2 1 0 nuclear exclusion +Mapt Tau ACETYLTRANSFERASE; Acetyltransferase; Cytoskeletal P10637 17762 11 67.79 cM|11 E1 mouse K613-ac 490850600 DLSKVTSkCGSLGNI Tubulin-binding acetylation cytoskeletal reorganization 28760828 2 1 0 impedes tau filament assembly +FOXM1 FOXM1 DNA-binding; Transcription factor Q08050 2305 12p13.33 human K440-ac 57807003 LSSAGPGkEEKLLFG activity, induced; protein stabilization; molecular association, regulation; phosphorylation carcinogenesis, induced; cell growth, induced; transcription, induced DNA(NOT_REPORTED) 27542221 1 1 0 +Tp53 p53 Activator; DNA-binding; Motility/polarity/chemotaxis; Nuclear receptor co-regulator; Transcription factor; Tumor suppressor P02340 22059 11 B3|11 42.83 cM mouse K369-me 2344805 HSSYLKTkKGQSTSR acetylation 18280244 5 0 0 increases p53 acetylation at multiple sites +RRAD RRAD G protein; G protein, monomeric; G protein, monomeric, RGK P55042 6236 16q22.1 human S257-p 457395 QIRLRRDsKEANARR molecular association, regulation Calmodulin(INDUCES) 9677319 1 0 0 +MASTL MASTL EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, AGC; Protein kinase, Ser/Thr (non-receptor) Q96GX5 84930 10p12.1 human S875-p 3209091 TAQHLTVsGFSL___ protein conformation; phosphorylation; enzymatic activity, induced cell cycle regulation RSK2(INDUCES) 21444715; 27563826 3 9 0 phosphorylation induces intramolecular interaction, which inhibits dephosphorylation at the same phospho site. +H3C1 H3 DNA-binding P68431 8350 6p22.2 human K4-m3 1458621 ____ARTkQTARKST Histone molecular association, regulation; acetylation; ubiquitination; methylation; intracellular localization cell cycle regulation; carcinogenesis, induced; carcinogenesis, inhibited; cell motility, induced; apoptosis, induced; cell growth, inhibited; transcription, induced; transcription, altered; signaling pathway regulation; DNA repair, induced; cell differentiation, induced; chromatin organization, altered; cell growth, induced; transcription, inhibited UHRF1(INDUCES); requiem(DISRUPTS); CDC45L(DISRUPTS); TAF140(INDUCES); ING2(INDUCES); RBBP4(DISRUPTS); TBP(INDUCES); FALZ(INDUCES); STAT1(INDUCES); ING4(INDUCES); GATAD1(INDUCES); GADD45A(INDUCES); RCOR1(INDUCES); C17orf49(INDUCES); MLL(INDUCES); RAG2(INDUCES); H2AZ(INDUCES); GCN5(INDUCES); FOXA2(INDUCES); H2AFV(INDUCES); CCDC101(INDUCES); PHF8(INDUCES); DPF3(DISRUPTS); FALZ iso4(INDUCES); JMJD2A(INDUCES); ING1(INDUCES); HCFC1(INDUCES); TRRAP(INDUCES) DNA(INDUCES) 16728974; 16728976; 16878130; 17305432; 17310985; 17351631; 17363312; 17567990; 18234970; 18701507; 18787082; 19021773; 19187765; 19229332; 19473514; 19503595; 19523850; 19524534; 19546172; 19734945; 19805358; 19885928; 19935671; 20003410; 20033197; 20043883; 20046871; 20053357; 20053926; 20080105; 20093418; 20190764; 20346720; 20404096; 20421419; 20452361; 20484083; 20548336; 20613843; 20818375; 20850016; 20953165; 20959362; 21059703; 21489993; 21565979; 22978410; 23159437; 23285160; 23353889; 23388825; 23408432; 23423141; 23518351; 25591470; 25656485; 26301496; 26783963; 31685992; 34155378; 35322029; 35346195; 35409160; 36060800 178 10 0 +SMAD1 SMAD1 DNA-binding; Transcription factor Q15797 4086 4q31.21 human S187-p 451173 NSHPFPHsPNSSYPN intracellular localization 9335504 4 0 0 Erk-mediated phosphorylation inhibits the nuclear accumulation of Smad1. +Men1 MEN1 Transcription, coactivator/corepressor Q9WVR8 29417 1q43 rat S487-p 18012114 RRGPRREsKPEEPPP Menin molecular association, regulation cell growth, induced; transcription, induced MYH9(INDUCES); ACTB(INDUCES) 30792230 2 13 1 induce insulin mRNA level and loss of its ability to repress cell proliferation. attenuation of SUV39H1and HDAC1 mediated repression +Acaca ACC1 Carbohydrate Metabolism - propanoate; Carbohydrate Metabolism - pyruvate; EC 6.3.4.14; EC 6.4.1.2; Ligase; Lipid Metabolism - fatty acid biosynthesis P11497 60581 10q26 rat S1215-p 449868 YGMTHVAsVSDVLLD ACC_central enzymatic activity, inhibited 7915280 3 7 2 +STK26 MST4 EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, STE; Protein kinase, Ser/Thr (non-receptor) Q9P289 51765 Xq26.2 human T178-p 4274125 DTQIKRNtFVGTPFW Pkinase intracellular localization cytoskeletal reorganization 19386264 3 19 63 +Git1 GIT1 GAP; GAP, ARF; Motility/polarity/chemotaxis Q9Z272 83709 10q24 rat Y330-p 15702200 FLPVNPEySATRNQG cell growth, induced 30355914 4 0 0 +DRD2 DRD2 GPCR, family 1; Membrane protein, integral; Membrane protein, multi-pass; Receptor, GPCR P14416 1813 11q23.2 human S321-p 31010702 GLHSTPDsPAKPEKN 7tm_1 receptor internalization, induced; receptor desensitization, inhibited signaling pathway regulation 24391960 1 1 0 decreased inhibition of the cAMP pathway +TSC2 TSC2 Cell cycle regulation; GAP; GAP, misc.; Nuclear receptor co-regulator; Tumor suppressor P49815 7249 16p13.3 human S664-p 455575 KKTSGPLsPPTGPPG Tuberin activity, induced; molecular association, regulation; enzymatic activity, induced TSC1(DISRUPTS) 15851026; 20008839 9 9 1 eIF4E activation through the AKT pathway leads to progression in NSCLC +GAB2 GAB2 Adaptor/scaffold Q9UQC2 9846 11q14.1 human Y293-p 449528 ETDNEDVyTFKTPSN molecular association, regulation CRKL(INDUCES) 11334882 1 14 172 +TP53 p53 Activator; DNA-binding; Motility/polarity/chemotaxis; Nuclear receptor co-regulator; Transcription factor; Tumor suppressor P04637 7157 17p13.1 human S37-p 447532 NVLSPLPsQAMDDLM TAD2 protein degradation; acetylation; protein stabilization; molecular association, regulation; phosphorylation; activity, induced; ubiquitination; protein conformation cell cycle regulation; carcinogenesis, induced; apoptosis, altered; cell growth, inhibited; apoptosis, induced; transcription, induced; transcription, altered; DNA repair, induced; cell growth, induced; apoptosis, inhibited; transcription, inhibited FBXW7(INDUCES); S100B(INDUCES); S100A1(INDUCES); S100A4(INDUCES); CBP(INDUCES); RPA1(INDUCES); PPP2CA(INDUCES); MDM2(DISRUPTS); S100A6(INDUCES); MDM2(INDUCES); S100A2(INDUCES) 10656682; 11042698; 11314044; 14665630; 14712210; 15471885; 16501611; 17891183; 19819244; 20024960; 20962272; 22797063; 27753536; 31296660; 31940492; 35951367; 9363941; 9744860 67 2 0 +OPTN optineurin Inhibitor Q96CV9 10133 10p13 human S473-p 9511914 AQMEVYCsDFHAERA CC2-LZ ubiquitination; intracellular localization 26365381; 27035970 3 2 0 +Ilf3 NFAT90 DNA-binding; Nucleolus; RNA-binding; Transcription factor Q9Z1X4 16201 9 A3|9 7.78 cM mouse T188-p 17734001 EKVLAGEtLSVNDPP DZF molecular association, regulation; intracellular localization translation, altered ILF2(DISRUPTS) 21123651 3 1 0 +NBR1 NBR1 Ubiquitin conjugating system Q14596 4077 17q21.31 human T586-p 33602700 HNTPVDVtPCMSPLP protein stabilization; molecular association, regulation; activity, inhibited SQSTM1(DISRUPTS) 24879152 1 1 0 inhibits function as a cargo adaptor protein, inhibits protein aggregation; phosphorylation slightly reduces its interaction with SQSTM1 +DDR2 DDR2 EC 2.7.10.1; KINASE; Kinase, protein; Membrane protein, integral; Protein kinase, TK; Protein kinase, tyrosine (receptor) Q16832 4921 1q23.3 human Y736-p 456861 FGMSRNLySGDYYRI PK_Tyr_Ser-Thr phosphorylation 16186108 1 9 409 Stimulates autophosphorylation. Autophosphorylation induces Shc binding (site not determined). +RUNX2 AML3 iso2 DNA-binding; Transcription factor Q13950-2 860 6p21.1 human S451-p 460684 MVPGGDRsPSRMLPP RunxI transcription, inhibited 32009983 5 0 0 decreased PDK4 levels, induces cell viability +Epas1 HIF2A DNA-binding; Transcription factor P97481 13819 17|17 E4 mouse T844-p 451301 PYLLPELtRYDCEVN HIF-1a_CTAD transcription, induced 11983697 1 0 0 +ASL ASL Amino Acid Metabolism - alanine, aspartate and glutamate; Amino Acid Metabolism - arginine and proline; EC 4.3.2.1; Endoplasmic reticulum; Lyase; Mitochondrial P04424 435 7q11.21 human S417-p 1880040200 LQELQTIsPLFSGDV molecular association, regulation; methylation; intracellular localization carcinogenesis, induced; chromatin organization, altered; transcription, induced GABPA(INDUCES) DNA(INDUCES) 36270249 1 0 0 induces H3K4 methylation +Rps6kb1 p70S6K EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, AGC; Protein kinase, Ser/Thr (non-receptor); Translation P67999 83840 10q26 rat S447-p 448357 GSPRTPVsPVKFSPG enzymatic activity, induced 11705993; 15774499 102 54 247 +MST1R Ron EC 2.7.10.1; KINASE; Kinase, protein; Membrane protein, integral; Protein kinase, TK; Protein kinase, tyrosine (receptor) Q04912 4486 3p21.31 human Y1353-p 456487 SALLGDHyVQLPATY molecular association, regulation; phosphorylation cell growth, altered Met(INDUCES) 10871856; 11064459 5 0 0 +SQSTM1 SQSTM1 Autophagy; Nuclear receptor co-regulator; Ubiquitin conjugating system Q13501 8878 5q35.3 human K435-ac 1879848303 LDTIQYSkHPPPL__ molecular association, regulation ubiquitin(INDUCES); SQSTM1(DISRUPTS) 31857589 1 1 0 enhances p62 body formation, clearance of poly-Ub proteins +RELA NFkB-p65 DNA-binding; Nuclear receptor co-regulator; Transcription factor Q04206 5970 11q13.1 human K221-ac 459094 LLCDKVQkEDIEVYF RHD_dimer molecular association, regulation; intracellular localization carcinogenesis, induced; apoptosis, inhibited; transcription, induced IkB-alpha(DISRUPTS) DNA(INDUCES) 12456660; 17268554; 18223231; 19345327; 21940946; 27007123 12 0 0 induces JCV activation +MAP4 MAP4 Cytoskeletal; Motility/polarity/chemotaxis P27816 4134 3p21.31 human K933-ac 36293768 NTSAPDLkNVRSKVG Tubulin-binding cytoskeletal reorganization 28002468 1 2 0 +Pax7 PAX7 DNA-binding; Oncoprotein; Transcription factor P47239 18509 4 D3|4 70.83 cM mouse S201-p 50592106 GNRLDEGsDVESEPD protein stabilization 26372956; 27144531 2 4 0 early commitment to terminal differentiation.; phosphorylation blocks caspase cleavage site, restricts differentiation and increase stem cell self-renewal +ROCK2 ROCK2 EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, AGC; Protein kinase, Ser/Thr (non-receptor) Q28021 282041 cow S1133-p 1732200 LHIGLDSsSIGSGPG enzymatic activity, induced cell cycle regulation 17446864 1 3 0 alanine mutation of all 4 sites +Cacna1b CACNA1B Channel, calcium; Membrane protein, integral; Membrane protein, multi-pass Q02294 257648 3p13 rat S2108-p 465549 RKQERGRsQERRQPS activity, induced 16704976; 19167461 2 0 0 +FFAR4 GPR120 GPCR, family 1; Lipid-binding; Membrane protein, integral; Membrane protein, multi-pass; Receptor, GPCR Q5NUL3 338557 10q23.33 human S350-p 31014808 GAILTDTsVKRNDLS activity, induced 27852822 5 1 0 +EFNB2 EFNB2 Ligand, receptor tyrosine kinase; Membrane protein, integral P52799 1948 13q33.3 human Y311-p 447829 YEKVSGDyGHPVYIV protein stabilization; protein conformation 12606549 2 10 126 +Cdh2 CDH2 Cell adhesion; Membrane protein, integral; Motility/polarity/chemotaxis P15116 12558 18 A1|18 10.1 cM mouse Y884-p 450693 SSGGDQDyDYLNDWG CADH_Y-type_LIR molecular association, regulation SHC1(INDUCES) 10502299 2 0 0 +APP APP Apoptosis; Cell surface; Membrane protein, integral; Receptor, misc.; Transcription factor P05067 351 21q21.3 human K763-ub 15384677 GYENPTYkFFEQMQN APP_amyloid protein processing; intracellular localization 29021256 2 7 1 An APP mutant that lacks all C-terminal lysines increased PSEN2-mediated processing of an increased pool of APP on the endosomal membrane. +CDC25A CDC25A EC 3.1.3.48; Motility/polarity/chemotaxis; PHOSPHATASE; Protein phosphatase, dual-specificity P30304 993 3p21.31 human S283-p 58934700 PERSQEEsPPGSTKR M-inducer_phosp protein degradation; ubiquitination; enzymatic activity, induced cell cycle regulation; apoptosis, inhibited 27580187; 34363019 2 2 0 +Drd1 DRD1 GPCR, family 1; Membrane protein, integral; Membrane protein, multi-pass; Receptor, GPCR P18901 24316 17p14 rat S258-p 455302 VECAQSEsSFKMSFK 7tm_1 receptor desensitization, altered 14660631 2 0 0 +IKBKE IKKE EC 2.7.11.10; Inhibitor; KINASE; Kinase, protein; Protein kinase, Other; Protein kinase, Ser/Thr (non-receptor) Q14164 9641 1q32.1 human K30-ub 40323317 VYKARNKkSGELVAV Pkinase molecular association, regulation; phosphorylation; enzymatic activity, induced carcinogenesis, induced; cell growth, induced; transcription, induced IKKB(INDUCES); IKKG(INDUCES) 23453969 1 1 0 regulates NF-kB pathway activation- TLR signaling, enhanced CYLD phosphorylation +PGR PR DNA-binding; Nuclear receptor; Transcription factor P06401 5241 11q22.1 human K7-sm 2890600 _MTELKAkGPRAPHV Prog_receptor sumoylation; protein stabilization; intracellular localization; protein conformation transcription, inhibited 17020914 1 0 0 induces sumoylation at other sites +SVIL supervillin Actin-binding; Contractile; Motility/polarity/chemotaxis; Nuclear receptor co-regulator O95425 6840 10p11.23 human S245-p 468887 SFTEVPRsPKHAHSS phosphorylation cell cycle regulation 36576983 1 64 13 induces RLC phosphorylation +PAK1 PAK1 EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, STE; Protein kinase, Ser/Thr (non-receptor) Q13153 5058 11q13.5-q14.1 human Y285-p 487520 QGASGTVyTAMDVAT Pkinase protein stabilization; molecular association, regulation; intracellular localization; enzymatic activity, induced carcinogenesis, induced; apoptosis, altered; cell motility, induced; transcription, induced; signaling pathway regulation; cell growth, induced; cell motility, altered; cytoskeletal reorganization GIT1(INDUCES); PXN(INDUCES); ARHGEF7(INDUCES); Snail1(INDUCES) 17726028; 21566085; 21719533; 23340249; 25125660; 25466889; 26944939; 27003261; 27542844 9 1 1 PAK1 phosphorylation stimulates PRL-induced tumor metastasis +EEF2 EEF2 Translation; Translation elongation P13639 1938 19p13.3 human T57-p 448040 RAGETRFtDTRKDEQ GTP_EFTU activity, inhibited; phosphorylation cell cycle regulation; carcinogenesis, inhibited; translation, altered; cell growth, inhibited; translation, induced; translation, inhibited 19036825; 21112387; 23184662; 30218597; 30786936; 35513296; 35841486 39 61 54 +MYH10 MYH10 Motility/polarity/chemotaxis; Motor P35580 4628 17p13.1 human S1952-p 465599 QLHLEGAsLELSDDD cytoskeletal reorganization 25869664 2 44 1 poorly defined actomyosin bundles distributed throughout the cell +CARD11 CARD11 Adaptor/scaffold Q9BXL7 84433 7p22.2 human S652-p 457639 LERPFRPsVTSVGHV activity, induced transcription, induced 24548923 6 0 0 NF-kB activation, IL-2 production +Yaf2 YAF2 Transcription, coactivator/corepressor Q99LW6 67057 15|15 E3 mouse S166-p 3205731 RGVSRSSsPRGEASS cell differentiation, inhibited; transcription, inhibited 29959227 2 24 2 regulation of H2AK119ub1 at specific promoters +Bmal1 BMAL1 DNA-binding; Transcription factor Q9WTL8 11865 7 F1|7 59.17 cM mouse S519-p 1878257202 IHRIRGSsPSSCGSS activity, induced transcription, induced 35902736 1 1 0 +Tp53 p53 Activator; DNA-binding; Motility/polarity/chemotaxis; Nuclear receptor co-regulator; Transcription factor; Tumor suppressor P02340 22059 11 B3|11 42.83 cM mouse K370-ac 458980 SSYLKTKkGQSTSRH activity, induced; molecular association, regulation cell growth, inhibited; apoptosis, induced; transcription, induced DNA(INDUCES) 21057544; 25758227; 33323382; 35534985 95 4 0 HDAC6 ablation induces senescence p21 expression and inhibits cell growth, HDAC6 ablation inhibits HC proliferation after two-thirds partial hepatectomy (PHx); P53K Q/- mice died prematurely due to anemia, loss of hematopoiesis stem cells, Loss of stem cells in the testis, activation in p53 KQ/- mice without robust p53 stabilization,p53-KQ/- mutant leads to effective suppression of tumor development in a pancreatic ductal adenocarcinoma mouse model, mutant proteins extended the life-span of a PDAC mouse model +P4HB PDIA1 EC 5.3.4.1; Endoplasmic reticulum; Isomerase; Nuclear receptor co-regulator; Oxidoreductase P07237 5034 17q25.3 human S357-p 56652490 KIKPHLMsQELPEDW molecular association, regulation; protein conformation; enzymatic activity, altered apoptosis, inhibited IRE1(INDUCES) 32149426 1 2 0 +MAP2K2 MEK2 EC 2.7.12.2; KINASE; Kinase, protein; Protein kinase, STE; Protein kinase, dual-specificity (non-receptor) P36507 5605 19p13.3 human S306-p 3295100 RPPGRPVsGHGMDSR Pkinase molecular association, regulation; protein conformation carcinogenesis, induced; cell motility, induced; cell adhesion, induced Akt1(INDUCES) 28225038 2 11 0 Interaction with AKT induces FOXO1 phosphorylation; metastasis in nude mice +MOB1B MOB1B Activator; Protein kinase, regulatory subunit Q7L9L4 92597 4q13.3 human T74-p 11555108 QINMLYGtITDFCTE Mob1_phocein molecular association, regulation NDR1(INDUCES); LATS2(INDUCES) 19919647 1 0 0 +RUNX1 AML1 DNA-binding; Oncoprotein; Transcription factor Q01196 861 21q22.12 human R210-me 2363102 QLRRTAMrVSPHHPA molecular association, regulation cell differentiation, altered; transcription, induced SIN3A(DISRUPTS) DNA(DISRUPTS) 18316480 2 1 0 +Klf4 KLF4 C2H2-type zinc finger protein; DNA-binding; Transcription factor Q923V7 114505 5q24 rat S469-p 22996306 QKCDRAFsRSDHLAL zf-C2H2 molecular association, regulation transcription, inhibited PPAR-gamma(INDUCES) 22282354 1 0 0 +IGFBP1 IGFBP1 Secreted; Secreted, signal peptide P08833 3484 7p12.3 human S144-p 451659 NFHLMAPsEEDHSIL activity, induced; molecular association, regulation; activity, inhibited; phosphorylation signaling pathway regulation IGF1(INDUCES); CK2B(INDUCES) 18772238; 19193607; 23354097; 25957086; 32502935 14 11 0 regulates mTOR and AAR signaling; inhibits IGF-1RB autophosphorylation and activity; S126A and S144A mutants inhibit IGF1R autophosphorylation +Gata4 GATA4 Motility/polarity/chemotaxis; Transcription factor Q08369 14463 14 D1|14 33.24 cM mouse K322-ac 18380900 QTRKRKPkNLNKSKT cell growth, induced; transcription, induced 20833366 1 0 0 +Tie1 TIE1 EC 2.7.10.1; KINASE; Kinase, protein; Membrane protein, integral; Protein kinase, TK; Protein kinase, tyrosine (receptor) Q06806 21846 4 D2.1|4 54.67 cM mouse Y1113-p 451279 MLEARKAyVNMSLFE molecular association, regulation transcription, altered PIK3R1(INDUCES) 11865050 1 0 0 +MAPT Tau iso8 ACETYLTRANSFERASE; Acetyltransferase; Cytoskeletal P10636-8 4137 17q21.31 human K353-ub 486346 FKDRVQSkIGSLDNI Tubulin-binding protein stabilization cytoskeletal reorganization 16443603; 32575755 1 3 0 di-ubiquitin chain at position K353, moderately but signi?cantly inhibits microtubule polymerization, di-ubiquitination retards ?lament formation +H3-3A H3 DNA-binding Q71LE2 396970 pig K4-m3 1458621 ____ARTkQTARKST Histone transcription, inhibited 32893712 178 10 0 mesenchymal stem/stroma cells of obese pigs had suppressed transcription compared to lean pigs +Akt3 Akt3 EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, AGC; Protein kinase, Ser/Thr (non-receptor) Q63484 29414 13q25 rat S34-p 484936 FLLKTDGsFIGYKEK PH enzymatic activity, inhibited 17308302 1 9 0 +Syn1 SYN1 Vesicle P09951 24949 Xq11 rat Y301-p 478277 VVALTKTyATAEPFI Synapsin_C molecular association, regulation Src(INDUCES); Fyn(INDUCES) 17400547; 20530578 2 0 2 increases interaction with synaptic vesicles and actin filaments +CELF1 CELF1 Cell development/differentiation; RNA processing; RNA-binding Q92879 10658 11p11.2 human S28-p 3347300 GQVPRTWsEKDLREL RRM_1 molecular association, regulation RNA splicing, altered; translation, altered RNA(INDUCES) 18570922; 24151077 3 9 1 splicing regulation in diabetes; increases CUGBP1 binding to cyclin D1 mRNA +YY1 YY1 C2H2-type zinc finger protein; Cell development/differentiation; Transcription factor P25490 7528 14q32.2 human K288-sm 3142604 RMKPRKIkEDDAPRT transcription, inhibited 17353273 1 2 0 +Gpsm1 GPSM1 GEF; GEF, misc. Q9R080 246254 3p13 rat T625-p 1345849601 DVLPRGPtMPDEDFF intracellular localization 30404823 1 0 0 regulation distribution of GPSM1 cellular puncta by T625 phosphorylation, cell stress and G-protein signaling +ATP7A ATP7A Apoptosis; Cell development/differentiation; Chaperone; EC 3.6.3.54; Hydrolase; Membrane protein, integral; Membrane protein, multi-pass; Transporter; Transporter, ion channel; Vesicle Q04656 538 Xq21.1 human T327-p 478062 KYNASSVtPESLRKA HMA protein conformation 21258844 2 8 26 S339 alters the dynamics of domain by increasing the flexibility whereas T327 decreasing the flexibility in Cu bound MBD3 +Tpm1 TPM1 Actin-binding; Motility/polarity/chemotaxis; Motor P58771 22003 9 C|9 36.27 cM mouse S283-p 451804 HALNDMTsI______ Tropomyosin enzymatic activity, induced; phosphorylation cytoskeletal reorganization; transcription, inhibited; signaling pathway regulation 23148217; 23232082; 23960072; 30567734 11 15 94 slows the Ca2+ regulation of myofilament; S283A mutant increases phosphorylation of PLB S16; regulation of muscle contraction and relaxation; phosphorylation of TPM1 at S283 causes a decrease in phosphorylation of PLB at S16 and T17.; modulates development of cardiac hypertrophy; Impairs diastolic function, regulates ERK pathway +Gabbr1 GABBR1 GPCR, family 3; Membrane protein, integral; Membrane protein, multi-pass; Receptor, GPCR Q9WV18 54393 17 B1|17 19.16 cM mouse S867-p 15167000 ITRGEWQsEAQDTMK receptor internalization, altered endocytosis, altered 20643921 3 0 1 +BIK BIK Apoptosis; Membrane protein, integral; Mitochondrial Q13323 638 22q13.2 human K160-ub 1877656600 GGLHLLLk_______ protein degradation; ubiquitination apoptosis, inhibited 31387940 1 0 0 IRE1alpha?XBP1 axis prevents premature apoptosis allows time for cell adaptation to ER stress +EGFR EGFR EC 2.7.10.1; KINASE; Kinase, protein; Membrane protein, integral; Oncoprotein; Protein kinase, TK; Protein kinase, tyrosine (receptor) P00533 1956 7p11.2 human R222-m2 56856900 CAQQCSGrCRGKSPS Furin-like intracellular localization; protein conformation; enzymatic activity, induced cell growth, induced 26571401 1 1 0 +KEAP1 KEAP1 Endoplasmic reticulum; Motility/polarity/chemotaxis; Transcription regulation; UBIQUITIN LIGASE; Ubiquitin conjugating system Q14145 9817 19p13.2 human S104-ga 1873356118 KVVLASSsPVFKAMF BTB protein degradation; ubiquitination transcription, inhibited CUL3(INDUCES) 28663241 1 0 0 NRF2 ubiquitination and degradation +Mapk1 ERK2 EC 2.7.11.24; KINASE; Kinase, protein; Protein kinase, CMGC; Protein kinase, Ser/Thr (non-receptor) P63085 26413 16 A3|16 10.53 cM mouse Y185-p 447594 HTGFLTEyVATRWYR Pkinase intracellular localization; enzymatic activity, induced carcinogenesis, induced; carcinogenesis, inhibited; cell growth, inhibited; transcription, induced; signaling pathway regulation; transcription, altered; neural plasticity; cell growth, induced; apoptosis, inhibited; cytoskeletal reorganization GAB1(INDUCES) 10593929; 10608864; 10867029; 11934884; 1319055; 15788406; 15975986; 16103085; 19004831; 21562256; 21706057; 21813649; 21887248; 21917714; 25584415; 34107247; 34191798; 37160873; 7504457; 8444886 1163 158 4003 +CENPJ CENPJ Cell cycle regulation; Microtubule-binding; Transcription, coactivator/corepressor Q9HC77 55835 13q12.12-q12.13 human S595-p 14918201 ISFSSNSsFVLKILE cell cycle regulation 20531387 1 0 0 required for centriole elongation +Irf4 IRF4 DNA-binding; Oncoprotein; Transcription factor Q64287 16364 13|13 A3.2 mouse K349-sm 56836800 LCSDRPNkLERDQTC IRF-3 protein stabilization cell cycle regulation; cell motility, induced; cell growth, induced; cell differentiation, induced; transcription, altered 27425617 1 0 0 +Casp4 CASP4 Apoptosis; EC 3.4.22.64; Protease P70343 12363 9 A1|9 2.46 cM mouse K62-ub 1877676800 WVFVDAMkKKHSKVG CARD protein degradation 30816303 1 0 0 +Atp6v1a ATP6V1A EC 3.6.3.14; Energy Metabolism - oxidative phosphorylation; Hydrolase P50516 11964 16|16 B4 mouse S384-p 485978 YLGARLAsFYERAGR ATP-synt_ab intracellular localization 23863464 1 12 0 apical plasma membrane localization in kidney 549 intercalated cells +LEMD3 MAN1 Membrane protein, integral; Membrane protein, multi-pass; Nuclear envelope Q9Y2U8 23592 12q14.3 human S402-p 3216873 GGAFSVDsPRIYSNS molecular association, regulation BAF(INDUCES) 19166343 1 18 0 +FGFR1 FGFR1 EC 2.7.10.1; KINASE; Kinase, protein; Membrane protein, integral; Oncoprotein; Protein kinase, TK; Protein kinase, tyrosine (receptor) P11362 2260 8p11.23 human Y653-p 447918 RDIHHIDyYKKTTNG PK_Tyr_Ser-Thr phosphorylation; enzymatic activity, induced cell differentiation, altered; cell motility, altered; cell growth, altered 16507368; 8622701 16 25 316 Double Y->F mutant has less neurite outgrowth in PC12 cells (differentiation), and less cell proliferation in L-6 cells.; Data collected by isolating phosphorylated species in vitro and confirming their phosphorylation states by mass spec. Y->F mutations were also done but unpublished. +TLN1 talin 1 Cytoskeletal; Motility/polarity/chemotaxis Q9Y490 7094 9p13.3 human T150-p 9764162 GTLRKDKtLLRDEKK cell motility, altered; cell adhesion, induced 27698901 1 5 1 +Trpv2 TRPV2 Channel, cation; Membrane protein, integral; Membrane protein, multi-pass Q9WUD2 29465 10q23 rat Y335-p 1877505000 RKFTEWCyGPVRVSL activity, induced; protein stabilization endocytosis, induced 35686730 1 1 0 +NR1I3 NR1I3 DNA-binding; Nuclear receptor Q14994 9970 1q23.3 human S192-p 458347 LPIEDQIsLLKGAAV Hormone_recep intracellular localization 16377764 1 0 1 +Dynll1 LC8 Microtubule-binding; Motility/polarity/chemotaxis; Motor P63168 56455 5|5 F mouse S88-p 454241 VAILLFKsG______ Dynein_light cytoskeletal reorganization 15504720 9 0 0 +SCN5A SCN5A Channel, sodium; Membrane protein, integral; Membrane protein, multi-pass Q14524 6331 3p22.2 human S525-p 451568 TSMKPRSsRGSIFTF Na_trans_cytopl activity, induced 12242273 6 6 1 +ZFHX3 ATBF1 C2H2-type zinc finger protein; Cell development/differentiation; DNA-binding; Mitochondrial; Transcription factor Q15911 463 16q22.2-q22.3 human K2806-sm 610813726 LLSPSSIkVEGIEDF protein stabilization carcinogenesis, induced; cell growth, induced 32249212 1 1 0 +HNF4A HNF4 alpha DNA-binding; Nuclear receptor; Transcription factor P41235 3172 20q13.12 human K126-ac 460633 KCFRAGMkKEAVQNE zf-C4 molecular association, regulation; intracellular localization; protein conformation transcription, induced Exportin-1(DISRUPTS); CBP(INDUCES) DNA(INDUCES) 10882110 1 0 0 +NEDD1 NEDD1 Cell cycle regulation Q8NHV4 121441 12q23.1 human S574-p 25533015 LSEKIADsIGNNRQN molecular association, regulation cytoskeletal reorganization TUBG1(INDUCES) 22595525 1 3 0 Promote NEDD1 activity; regulates spindle assembly in mitosis +GTF2I GTF2I iso2 DNA-binding; Transcription, coactivator/corepressor P78347-2 2969 7q11.23 human Y249-p 459606 ESEDPDYyQYNIQGS cell cycle regulation; transcription, altered 16314517 5 1 1 +MAFA MAFA DNA-binding; Oncoprotein; Transcription factor; Tumor suppressor Q8NHW3 389692 8q24.3 human S14-p 1713900 MGAELPSsPLAIEYV activity, induced cell differentiation, altered; transcription, induced 11416124 2 2 0 activation of crystallin and NQO1 expression +SMURF1 SMURF1 EC 6.3.2.-; EC 6.3.2.19; Ligase; UBIQUITIN LIGASE; Ubiquitin conjugating system; Ubiquitin ligase Q9HCE7 57154 7q22.1 human T223-p 1877492900 DVRGSLQtPQNRPHG molecular association, regulation carcinogenesis, induced; cell motility, induced; cytoskeletal reorganization RHOA(INDUCES) 35654587 1 1 0 induces RhoA polyubiquitination +Ace2 ACE2 EC 3.4.17.23; Membrane protein, integral; Protease Q8R0I0 70008 X F5|X 76.12 cM mouse K788-ub 1869999601 YDSMDIGkGESNAGF protein degradation 32755395 1 0 0 +PLAGL2 PLAGL2 C2H2-type zinc finger protein; DNA-binding Q9UPG8 5326 20q11.21 human K356-ac 483052 YLPDKLPkVEVDSFL sumoylation transcription, induced 17551969 1 0 0 acetylation abolishes sumoylation on the same three residues, promoter-specific transcription +BMI1 BMI1 EC 6.3.2.-; Ligase; Motility/polarity/chemotaxis; Oncoprotein; UBIQUITIN LIGASE; Ubiquitin conjugating system; Ubiquitin ligase P35226 648 10p12.2 human S316-p 6150348 ANRPRKSsVNGSSAT molecular association, regulation carcinogenesis, inhibited; cell growth, inhibited DNA(DISRUPTS) 23092893 2 1 50 inhibits self-renewal of hematopoietic progenitor cells +ELP3 ELP3 ACETYLTRANSFERASE; Acetyltransferase; EC 2.3.1.48 Q9H9T3 55140 8p21.1 human Y202-p 450611 GHTSNNIyEAVKYSE Radical_SAM carcinogenesis, induced; cell growth, induced; transcription, induced 31341009 1 12 345 +AICDA AID EC 3.5.4.38; Hydrolase Q9GZX7 57379 12p13.31 human S38-p 457604 YVVKRRDsATSFSLD APOBEC2 enzymatic activity, induced 16387847 12 3 0 +AGO2 AGO2 EC 3.1.26.n2; RNA processing; RNA-binding Q9UKV8 27161 8q24.3 human S831-p 7104887 SAEGSHTsGQSNGRD molecular association, regulation; activity, inhibited; phosphorylation transcription, inhibited RNA(DISRUPTS) 28114302 3 5 0 induces phosphorylation at S834; regulates miRNA silencing +CDK6 CDK6 Cell cycle regulation; EC 2.7.11.22; KINASE; Kinase, protein; Protein kinase, CMGC; Protein kinase, Ser/Thr (non-receptor) Q00534 1021 7q21.2 human Y24-p 448903 AEIGEGAyGKVFKAR Pkinase molecular association, regulation; enzymatic activity, inhibited; activity, inhibited cell cycle regulation CCND3(DISRUPTS); CCND1(DISRUPTS) 23429262 1 4 248 +CHEK1 Chk1 EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, CAMK; Protein kinase, Ser/Thr (non-receptor); Tumor suppressor O14757 1111 11q24.2 human S317-p 447833 ENVKYSSsQPEPRTG protein stabilization; molecular association, regulation; enzymatic activity, inhibited; phosphorylation; enzymatic activity, induced cell cycle regulation; DNA repair, induced; carcinogenesis, induced; apoptosis, inhibited; signaling pathway regulation claspin(INDUCES) DNA(INDUCES) 11390642; 12588868; 15707391; 16963448; 18272544; 19091954; 21907702; 23454898; 24240236; 24632611; 24876101; 26082189; 26658951; 31591366; 32076484; 32357935; 33503415; 34385259; 35740300; 36781846 103 11 17 +BAK1 BAK1 Apoptosis; Endoplasmic reticulum; Membrane protein, integral; Mitochondrial Q16611 578 6p21.31 human Y110-p 15794304 TAENAYEyFTKIATS Bcl-2 activity, induced; molecular association, regulation; protein conformation apoptosis, inhibited BAK1(DISRUPTS); BID(INDUCES) 23782464 2 1 0 +MTOR mTOR Autophagy; EC 2.7.11.1; KINASE; Kinase, protein; Motility/polarity/chemotaxis; Protein kinase, Ser/Thr (non-receptor); Protein kinase, atypical P42345 2475 1p36.22 human S2448-p 447578 RSRTRTDsYSAGQSV intracellular localization; phosphorylation; enzymatic activity, induced cell cycle regulation; carcinogenesis, induced; apoptosis, induced; cell motility, induced; transcription, induced; transcription, altered; signaling pathway regulation; cell growth, induced; apoptosis, inhibited; autophagy, inhibited; translation, induced 12807916; 19079619; 21602892; 21893193; 24590173; 25020061; 31802035; 33658337; 33755959; 33835469; 33845796; 33967735; 34194551; 34604061; 34820368; 35253622; 35279705; 35368866; 35443161; 35841593; 35907820; 36008391; 36139911; 36149602; 36357572; 36413544; 36418288; 36471885; 36635496 218 18 106 +RAD51 RAD51 DNA repair, damage; Mitochondrial Q06609 5888 15q15.1 human T309-p 455229 LRKGRGEtRICKIYD Rad51 activity, induced cell cycle regulation; DNA repair, induced; carcinogenesis, altered; DNA repair, altered 15665856; 34197606; 36692427 3 0 0 +YY1 YY1 C2H2-type zinc finger protein; Cell development/differentiation; Transcription factor P25490 7528 14q32.2 human T348-p 3189352 KRHQLVHtGEKPFQC molecular association, regulation; intracellular localization DNA(DISRUPTS) 19793915 1 11 6 in mitotic cells +RGS13 RGS13 GAP; GAP, RGS O14921 6003 1q31.2 human T41-p 15785722 SFENLMAtKYGPVVY RGS protein stabilization 20974683 1 1 0 +FOXM1 FOXM1 DNA-binding; Transcription factor Q08050 2305 12p13.33 human S331-p 3194567 FKPLDPGsPQLPEHL activity, induced; molecular association, regulation cell growth, induced PIN1(INDUCES) 26279295 2 5 0 +MDC1 MDC1 Cell cycle regulation Q14676 9656 6p21.33 human S329-p 453669 QPFGFIDsDTDAEEE molecular association, regulation cell cycle regulation NBS1(INDUCES) 18678890 1 33 23 MDC1-NBS1 interaction regulates intra-S-phase checkpoint activation +NDC80 HEC1 Cell cycle regulation O14777 10403 18p11.32 human S7-p 1881198900 _MKRSSVsSGGAGRL cell cycle regulation 36897279 1 1 0 +Gja1 GJA1 Channel, misc.; Membrane protein, integral; Membrane protein, multi-pass; Motility/polarity/chemotaxis P08050 24392 20q11 rat Y265-p 447815 KDCGSPKyAYFNGCS activity, induced; molecular association, regulation; intracellular localization; activity, inhibited carcinogenesis, altered; cytoskeletal reorganization; cell adhesion, altered; cell growth, altered CTNNB1(DISRUPTS); Src(INDUCES); PTPN2(INDUCES); DBN1(INDUCES) 11124251; 14681032; 16916748; 20676131; 24849651; 27280719; 27391443; 29882937; 32956670 26 3 11 allows anchorage-independent growth; inhibits Src activity; disrupts gap junction communication; regulation of gap junction intercellular communication +TSC1 TSC1 Motility/polarity/chemotaxis; Tumor suppressor Q92574 7248 9q34.13 human S487-p 5277800 AAISRELsEITTAEA Hamartin protein degradation; molecular association, regulation; ubiquitination; phosphorylation carcinogenesis, induced; cell growth, induced; signaling pathway regulation TSC2(DISRUPTS) 17693255 2 6 3 induces S6K1 phosphorylation, activates mTOR pathway +Cryaa CRYA1 Chaperone; Heat shock protein P24622 12954 17 B1|17 17.09 cM mouse S171-p 452108 FSGPKVQsGLDAGHS HSP20 apoptosis, inhibited 29467334 5 5 0 attenuation of ER stress; regulates neuroprotective function +CDH1 CDH1 Cell adhesion; Membrane protein, integral; Motility/polarity/chemotaxis; UBIQUITIN LIGASE; Ubiquitin ligase P12830 999 16q22.1 human Y754-p 456025 DTRDNVYyYDEEGGG molecular association, regulation endocytosis, induced CBLL1(INDUCES) 22252131; 29311227 3 2 44 +TNFRSF1A TNF-R1 Membrane protein, integral; Receptor, cytokine P19438 7132 12p13.31 human S381-p 20831307 FVRRLGLsDHEIDRL Death molecular association, regulation cell motility, induced; transcription, induced TRADD(INDUCES) 21724995 1 0 0 +SIT1 SIT Adaptor/scaffold; Membrane protein, integral Q9Y3P8 27240 9p13.3 human Y90-p 448963 SVEEVPLyGNLHYLQ SIT molecular association, regulation GRB2(INDUCES) 11433379 1 10 337 Y90 is major binding site. +Atp1a1 ATP1A1 EC 3.6.3.9; Hydrolase; Membrane protein, integral; Membrane protein, multi-pass; Transporter; Transporter, ion channel P06685 24211 2q34 rat S16-p 449086 KYEPAAVsEHGDKKS protein degradation; molecular association, regulation; enzymatic activity, inhibited; intracellular localization; protein conformation; enzymatic activity, induced AP2A1(INDUCES); AP-2 alpha(INDUCES) 10716725; 10933807; 12466249; 12759348; 14976217; 16338965; 16949583; 27605582 13 25 0 +MAPK14 P38A EC 2.7.11.24; KINASE; Kinase, protein; Protein kinase, CMGC; Protein kinase, Ser/Thr (non-receptor) Q16539 1432 6p21.31 human K152-sm 1881371307 DIIHRDLkPSNLAVN protein stabilization; intracellular localization 34686655 1 0 0 nuclear translocation, metastasis, OS response +Rb1 Rb Nuclear receptor co-regulator; Oncoprotein; Transcription, coactivator/corepressor; Tumor suppressor P13405 19645 14 38.73 cM|14 D3 mouse T819-p 447984 LPTPTKMtPRSRILV Rb_C molecular association, regulation; phosphorylation cell cycle regulation; chromatin organization, altered; cell growth, induced; DNA repair, inhibited E2F1(DISRUPTS); SUV420H1(DISRUPTS); SUV420H2(DISRUPTS) 10207050; 35023164 20 37 56 +Sufu SUFU Adaptor/scaffold; Transcription, coactivator/corepressor; Tumor suppressor Q9Z0P7 24069 19 C3|19 38.85 cM mouse S346-p 4786848 RAPSRKDsLGSDSST SUFU_C intracellular localization Exportin-1(DISRUPTS) 27849569 4 30 3 nuclear localization +REM1 REM1 G protein; G protein, monomeric; G protein, monomeric, RGK O75628 28954 20q11.21 human S18-p 4697668 TPLHRRAsTPLPLSP activity, induced; molecular association, regulation 14-3-3 beta(INDUCES); CACNA1C(DISRUPTS) 22076634 1 8 5 +Pak1 PAK1 EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, STE; Protein kinase, Ser/Thr (non-receptor) O88643 18479 7 E1|7 53.57 cM mouse T423-p 448177 PEQSKRStMVGTPYW Pkinase enzymatic activity, induced 12719581 39 4 11 +Rbpms RBPMS Motility/polarity/chemotaxis Q9WVB0 19663 8|8 A4 mouse T113-p 3208557 AKNKLVGtPNPSTPL molecular association, regulation; activity, inhibited RBPMS(DISRUPTS) RNA(DISRUPTS) 36408906 1 8 1 +TSC2 TSC2 Cell cycle regulation; GAP; GAP, misc.; Nuclear receptor co-regulator; Tumor suppressor P49815 7249 16p13.3 human S1452-p 3191272 LPSSSPRsPSGLRPR activity, inhibited; phosphorylation cell cycle regulation; cell growth, induced; translation, induced 32294430 2 14 0 induces S6K phosphorylation +CDC25B CDC25B EC 3.1.3.48; Motility/polarity/chemotaxis; Nuclear receptor co-regulator; PHOSPHATASE; Protein phosphatase, dual-specificity P30305 994 20p13 human S321-p 459625 KCQRLFRsPSMPCSV M-inducer_phosp molecular association, regulation; intracellular localization; phosphorylation; enzymatic activity, induced 14-3-3 beta(DISRUPTS); 14-3-3 epsilon(DISRUPTS) 20801879 2 2 3 S321 phosphorylation disrupts binding of S323 to 14-3-3, resulting in S323 dephosphorylation +MDM2 MDM2 EC 6.3.2.-; EC 6.3.2.19; Inhibitor; Ligase; NEDDYLATION LIGASE; Neddylation Ligase; Nucleolus; Oncoprotein; UBIQUITIN LIGASE; Ubiquitin conjugating system; Ubiquitin ligase Q00987 4193 12q15 human S17-p 9184307 TDGAVTTsQIPASEQ protein degradation; molecular association, regulation; protein conformation; enzymatic activity, induced p53(INDUCES); p53(DISRUPTS) 19568783; 21191186; 22815859; 25543083 4 0 0 S17 phosphorylation gives rise to the 'closed' form of truncated lid.; increases thermostability of the isolated N-terminal domain +Ppp1r9b Spinophilin Adaptor/scaffold; Protein phosphatase, regulatory subunit Q6R891 217124 11|11 D mouse Y398-p 22879101 DLVDVSAySGLGEDS molecular association, regulation SHP-1(INDUCES) 22210881 1 0 0 +ELAVL1 HuR RNA-binding Q15717 1994 19p13.2 human K182-ub 7761225 SSEPITVkFAANPNQ protein degradation; molecular association, regulation RNA(DISRUPTS) 19322201; 26434587; 36968077 3 2 0 degradation under heat shock +FLNC FLNC Cytoskeletal; Motility/polarity/chemotaxis Q14315 2318 7q32.1 human S2623-p 27449343 KSSSSRGsSYSSIPK protein stabilization 28028127 1 3 0 +IGF1R IGF1R EC 2.7.10.1; KINASE; Kinase, protein; Membrane protein, integral; Protein kinase, TK; Protein kinase, tyrosine (receptor) P08069 3480 15q26.3 human K1055-sm 12723518 LNEASVMkEFNCHHV PK_Tyr_Ser-Thr intracellular localization cell growth, induced; transcription, induced DNA(INDUCES) 20145208; 25448401 2 0 0 +PPP1R1A PPP1R1A Inhibitor; Protein phosphatase, regulatory subunit Q13522 5502 12q13.2 human T35-p 447759 QIRRRRPtPATLVLT DARPP-32 molecular association, regulation; enzymatic activity, inhibited; enzymatic activity, induced PPP1CA(INDUCES) 10811908; 29311589 14 4 0 PKA-thiophosphorylated form of inhibitor-1 displays a different affnity to native and recombinant enzyme +Rin1 Rin1 GEF; GEF, Rab Q921Q7 225870 19|19 A mouse Y35-p 450778 KPSTDPLyDTPDTRG molecular association, regulation Arg(INDUCES) 15886098 1 39 1026 +NPR1 ANPA EC 4.6.1.2; Guanylyl cyclase; KINASE; Kinase, protein; Lyase; Membrane protein, integral; Nucleotide Metabolism - purine; Protein kinase, RGC; Protein kinase, dual-specificity (receptor); Receptor, misc. P16066 4881 1q21.3 human S534-p 447514 AGSRLTLsGRGSNYG activity, induced; enzymatic activity, induced 28416574; 9528788 3 2 1 +Nr4a1 Nur77 Apoptosis; DNA-binding; Nuclear receptor P12813 15370 15|15 F1 mouse S354-p 447942 GRRGRLPsKPKQPPD activity, inhibited transcription, altered 16223362; 9322922 11 4 0 +TP63 p63 DNA-binding; Transcription factor Q9H3D4 8626 3q28 human S160-p 451600 SSTFDALsPSPAIPS protein stabilization; intracellular localization 23420876 6 2 0 nuclear stabilization of phosphorylated p63 in response to paclitaxel, partially relocates to the mitochondria +LIMD1 LIMD1 Motility/polarity/chemotaxis; Tumor suppressor Q9UGP4 8994 3p21.31 human S272-p 451974 TASSQRVsPGLPSPN cell cycle regulation; carcinogenesis, inhibited; cell growth, inhibited; cell motility, inhibited 30600590 1 19 2 mitotic phosphorylation required for mitotic progression +EGLN2 EGLN2 EC 1.14.11.29; Oxidoreductase Q96KS0 112398 19q13.2 human S130-p 31088285 EDGGDAPsPSKRPWA molecular association, regulation cell cycle regulation HIF1A(DISRUPTS) 26644182 1 5 0 +DVL3 DVL3 Motility/polarity/chemotaxis Q92997 1857 3q27.1 human S633-p 34668137 GPAASEHsHRSHHSL Dsh_C intracellular localization 24993822 1 1 0 +Dok1 DOK1 Adaptor/scaffold; Motility/polarity/chemotaxis P97465 13448 6 C3|6 35.94 cM mouse Y295-p 448366 LGSPPALyAEPLDSL molecular association, regulation cell growth, inhibited RASA1(INDUCES) 25043303 4 14 166 +Axin1 axin 1 Adaptor/scaffold; Tumor suppressor O70239 79257 10q12 rat S317-p 2226504 YALAPATsANDSEQQ cytoskeletal reorganization 22933777 1 0 0 Phosphorylation regulates responsive to Sema3A induced growth cone collapse. +OTUD6A OTUD6A DEUBIQUITINASE; EC 3.4.19.12; Ubiquitin-specific protease Q7L8S5 139562 Xq13.1 human S70-p 40512702 LEKFQDDsSIESVVE molecular association, regulation; intracellular localization cell cycle regulation; carcinogenesis, induced TOPBP1(DISRUPTS) 35768646 1 2 0 +RNF4 RNF4 EC 6.3.2.-; Ligase; Nuclear receptor co-regulator; Transcription factor; UBIQUITIN LIGASE; Ubiquitin conjugating system; Ubiquitin ligase P78317 6047 4p16.3 human T112-p 3801490 DVYVTTHtPRNARDE enzymatic activity, induced 25948581 1 2 6 regulates homologous recombination repair during S-phase +PAK6 PAK6 EC 2.7.11.1; KINASE; Kinase, protein; Nuclear receptor co-regulator; Protein kinase, STE; Protein kinase, Ser/Thr (non-receptor) Q9NQU5 56924 15q15.1 human S560-p 450316 KDVPKRKsLVGTPYW Pkinase enzymatic activity, induced 15550393 2 15 42 +Dnm2 DYN2 EC 3.6.5.5; Hydrolase; Microtubule-binding; Motility/polarity/chemotaxis; Vesicle P39054 13430 9 A3|9 7.79 cM mouse Y231-p 451199 LLPLRRGyIGVVNRS Dynamin_M cytoskeletal reorganization 21411625 4 1 0 promotes focal adhesion turnover +ATP2A2 SERCA2 Cell adhesion; EC 3.6.3.8; Endoplasmic reticulum; Hydrolase; Membrane protein, integral; Membrane protein, multi-pass; Transporter; Transporter, ion channel P16615 488 12q24.11 human K480-sm 25092201 SVIKQLMkKEFTLEF Cation_ATPase protein stabilization; molecular association, regulation; ubiquitination; enzymatic activity, induced Other(INDUCES) 21900893 2 0 0 induces ATP binding, inhibits ubiquitination +Kcnj3 GIRK1 Channel, potassium; Membrane protein, integral; Membrane protein, multi-pass P63251 50599 3q21 rat T407-p 10769101 PSKLQKItGREDFPK activity, induced 19765080 2 0 0 +PPP1R12A MYPT1 Motility/polarity/chemotaxis; PHOSPHATASE; Protein phosphatase, regulatory subunit O14974 4659 12q21.2-q21.31 human S472-p 452042 AGVTRSAsSPRLSSS molecular association, regulation cell adhesion, altered 14-3-3 beta(INDUCES) 20354225 2 12 40 +Yap1 YAP1 Oncoprotein; Transcription, coactivator/corepressor P46938 22601 9|9 A1 mouse S382-p 3190672 TYHSRDEsTDSGLSM protein degradation; intracellular localization; activity, inhibited carcinogenesis, inhibited; carcinogenesis, altered; cell motility, induced; cell growth, inhibited; transcription, inhibited 34608264; 34678143; 35619099; 36170819; 36374802 32 13 5 +HDAC2 HDAC2 DEACETYLASE; Deacetylase; EC 3.5.1.98; Nuclear receptor co-regulator; Transcription, coactivator/corepressor Q92769 3066 6q21 human K462-sm 27490400 EDKKTDVkEEDKSKD molecular association, regulation apoptosis, inhibited p53(INDUCES) 22493095 2 1 0 +Elk1 ELK1 DNA-binding; Transcription factor A4GTP4 314436 Xq11 rat K253-sm 3982501 EVKVEGPkEELEVTE apoptosis, inhibited; transcription, inhibited 30849179 3 1 0 GADD45A expression; APP/PS1 rats +Tal1 TAL1 DNA-binding; Oncoprotein; Transcription factor P22091 21349 4 D1|4 52.73 cM mouse S172-p 4704529 NRVKRRPsPYEMEIS molecular association, regulation DNA(DISRUPTS) 9111058 2 2 1 +WASL N-WASP Adaptor/scaffold; Motility/polarity/chemotaxis O00401 8976 7q31.32 human S484-p 3149548 KRSKAIHsSDEDEDE activity, induced; molecular association, regulation; intracellular localization; phosphorylation cell motility, induced; cytoskeletal reorganization PAK4(INDUCES) 21097841; 21898535; 29100370 4 19 2 +CACYBP CACYBP Adaptor/scaffold; Ubiquitin conjugating system Q9HB71 27101 1q25.1 human K14-ub 22241672 QKDLEEVkVLLEKAT Siah-Interact_N apoptosis, induced; autophagy, inhibited 31213539 1 4 0 on DNA damage +KIF20A KIF20A Microtubule-binding; Motor O95235 10112 5q31.2 human S532-p 459833 KEHSLQVsPSLEKGA molecular association, regulation; intracellular localization; protein conformation cell cycle regulation AurB(DISRUPTS); INCENP(DISRUPTS) 24656812 1 30 0 favours solubility, inhibits microtubule binding +SKA3 SKA3 Cell cycle regulation Q8IX90 221150 13q12.11 human T358-p 459962 SYENLLRtPTPPEVT molecular association, regulation; intracellular localization cell cycle regulation; chromatin organization, altered; cytoskeletal reorganization HEC1(INDUCES) 28479321; 32491969 2 6 6 +YWHAZ 14-3-3 zeta Adaptor/scaffold; Motility/polarity/chemotaxis P63104 7534 8q22.3 human K49-ac 474726 NLLSVAYkNVVGARR 14-3-3 molecular association, regulation apoptosis, induced KIF11(DISRUPTS); ATG9A(DISRUPTS); AS160(DISRUPTS); BAD(DISRUPTS) 25770209 1 6 15 +Atxn1 ataxin-1 Nuclear export; RNA-binding P54254 20238 13 A5|13 21.98 cM mouse S751-p 449110 ATRKRRWsAPETRKL protein stabilization; molecular association, regulation; intracellular localization; phosphorylation apoptosis, altered; transcription, altered 14-3-3 epsilon(INDUCES) 20869591; 21835928; 29860311; 33554954 19 28 3 +PLAGL2 PLAGL2 C2H2-type zinc finger protein; DNA-binding Q9UPG8 5326 20q11.21 human K269-ac 483053 CSSTVSVkEELSPVL sumoylation transcription, induced 17551969 1 0 0 acetylation abolishes sumoylation on the same three residues, promoter-specific transcription +Aurkb AurB EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, Other; Protein kinase, Ser/Thr (non-receptor) O70126 20877 11 B3|11 42.32 cM mouse K207-ub 21129738 KVIHRDIkPENLLLG Pkinase protein degradation cell cycle regulation; carcinogenesis, inhibited; apoptosis, induced 23928698 2 4 0 +GATA3 GATA3 Transcription factor P23771 2625 10p14 human K292-ac 460636 NACGLYHkMNGQNRP GATA intracellular localization cell growth, inhibited; transcription, induced 10970860 1 0 0 regulated survival after activation, regulates T-cell trafficking to secondary +Gria2 GluR2 Channel, calcium; Channel, ligand-gated; Membrane protein, integral; Membrane protein, multi-pass P23819 14800 3 E3|3 35.5 cM mouse S880-p 448351 YNVYGIEsVKI____ receptor internalization, induced; receptor internalization, altered neural plasticity; endocytosis, induced 19279258; 31969804; 32071234; 35710984; 37626185 30 1 0 +CAMK2A CAMK2A iso2 EC 2.7.11.17; KINASE; Kinase, protein; Protein kinase, CAMK; Protein kinase, Ser/Thr (non-receptor) Q9UQM7-2 815 5q32 human T305-p 448802 KLKGAILtTMLATRN molecular association, regulation; intracellular localization; enzymatic activity, inhibited; phosphorylation NMDAR2B(DISRUPTS) 28636948 24 5 1 inhibits phosphorylation at T286, regulates LTP, fear memory, spatial learning +AATF AATF Nucleolus; RNA-binding; Transcription factor Q9NY61 26574 17q12 human S320-p 460426 NAGSEEIsSEDDELV AATF-Che1 acetylation chromatin organization, altered; cell growth, induced; transcription, induced H3(INDUCES) 34266450 1 53 7 induces histone acetylation +DRD1 DRD1 GPCR, family 1; Membrane protein, integral; Membrane protein, multi-pass; Receptor, GPCR P21728 1812 5q35.2 human S258-p 455302 VECSQPEsSFKMSFK 7tm_1 molecular association, regulation signaling pathway regulation G-alpha(s)(DISRUPTS); ARR3(INDUCES) 32503917 2 0 0 ERK1/2 activation +RPS6KB1 p70S6K EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, AGC; Protein kinase, Ser/Thr (non-receptor); Translation P23443 6198 17q23.1 human T412-p 448607 NQVFLGFtYVAPSVL Pkinase_C activity, induced; molecular association, regulation; intracellular localization; phosphorylation; enzymatic activity, induced cell cycle regulation; carcinogenesis, induced; carcinogenesis, inhibited; cell motility, induced; cell growth, inhibited; transcription, induced; signaling pathway regulation; translation, altered; autophagy, induced; cell growth, induced; apoptosis, inhibited; autophagy, inhibited; cell adhesion, altered; translation, induced; translation, inhibited ELF4(DISRUPTS); ELF3(INDUCES) 11684675; 12036952; 12609989; 12807916; 12970779; 14660640; 15028555; 15304500; 17347671; 17446865; 17936702; 19079619; 20599721; 21394080; 21602892; 21734039; 21986499; 24396066; 24954509; 25738361; 31802035; 33658337; 34336098; 34518212; 34546793; 34673774; 34737445; 35015571; 35077510; 35288456; 36357572; 36787291; 37507012; 7489717; 7545671; 9218810 476 9 1 +CENPC CENPC1 Q03188 1060 4q13.2 human T734-p 14571365 KLVLPSNtPNVRRTK molecular association, regulation; intracellular localization cell cycle regulation CENPT(INDUCES); CENPA(INDUCES) 31676716 1 20 7 +SMN1 SMN RNA processing; RNA-binding Q16637 6606 5q13.2 human S49-p 1873529903 AYDKAVAsFKHALKN SMN molecular association, regulation; protein conformation cell growth, induced SMN(INDUCES) 34161763 1 1 0 +ELK4 ELK4 DNA-binding; Transcription, coactivator/corepressor P28324 2005 1q32.1 human K167-sm 25352009 VKLFKLIkTENPAEK transcription, inhibited 20637912 1 1 0 +TP53 p53 Activator; DNA-binding; Motility/polarity/chemotaxis; Nuclear receptor co-regulator; Transcription factor; Tumor suppressor P04637 7157 17p13.1 human K370-m1 2574935 RAHSSHLkSKKGQST molecular association, regulation; protein conformation; activity, inhibited carcinogenesis, inhibited; transcription, induced; transcription, inhibited JMJD2A(INDUCES); 53BP1(INDUCES) DNA(DISRUPTS) 17108971; 17805299; 19334741; 27535933; 31069954 5 3 0 +SFRP4 SFRP4 Secreted; Secreted, signal peptide Q6FHJ7 6424 7p14.1 human T189-p 50799492 KVKPTLAtYLSKNYS NTR molecular association, regulation carcinogenesis, induced; transcription, induced; signaling pathway regulation CTNNB1(INDUCES) 31390565 1 1 0 induces B-catenin transcriptional activity and CD133 expression, regulates Wnt/B-catenin signaling pathway +RNF187 RNF187 EC 6.3.2.-; EC 6.3.2.19; UBIQUITIN LIGASE; Ubiquitin conjugating system; Ubiquitin ligase Q5TA31 149603 1q42.13 human R98-me 347475300 AALQLLCrADAGPLC protein stabilization; molecular association, regulation; protein conformation transcription, induced Jun(INDUCES) 23624934 1 1 0 dimerisation, expression of Jun target genes +HSP90AB1 HSP90B Chaperone; Heat shock protein P08238 3326 6p21.1 human Y301-p 462282 DDITQEEyGEFYKSL HSP90 molecular association, regulation; protein conformation eNOS(INDUCES) 17855507; 23867252 2 3 11 phosphorylation induces altered conformation and governs drug specificity.; promotes NO(2-) release +L1CAM NCAM-L1 Cell adhesion; Membrane protein, integral P32004 3897 Xq28 human Y1229-p 10272401 DGSFIGQySGKKEKE Bravo_FIGEY activity, induced; molecular association, regulation; protein conformation; phosphorylation cytoskeletal reorganization; signaling pathway regulation ANK3(DISRUPTS) 19720049; 31640849 5 0 4 +PKP1 plakophilin 1 Cell adhesion; Motility/polarity/chemotaxis Q13835 5317 1q32.1 human T180-p 27717309 GSKGQKTtQNRYSFY activity, induced; protein stabilization cell motility, induced; cell growth, induced; translation, induced; cell adhesion, inhibited 23444369 1 1 0 +SIRT1 SIRT1 Apoptosis; DEACETYLASE; Deacetylase; EC 3.5.1.-; Nuclear receptor co-regulator Q96EB6 23411 10q21.3 human S682-p 41401500 SDSGTCQsPSLEEPM intracellular localization apoptosis, induced; transcription, induced 26113041 1 0 0 localized to PML-NBs, facilitates efficient p53 acetylation, potentiates apoptotic p53 target gene expression +THRB TR-beta1 DNA-binding; Nuclear receptor P10828 7068 3p24.2 human K50-sm 27490401 SERRSTLkNEQSSPH molecular association, regulation; intracellular localization cell growth, induced; cell differentiation, induced; transcription, induced; signaling pathway regulation; transcription, altered CBP(DISRUPTS); Src(INDUCES); N-CoR1(INDUCES) DNA(INDUCES); DNA(DISRUPTS) 22930759; 25572392; 27843805 4 0 0 +Wasf1 WAVE1 Cytoskeletal; Motility/polarity/chemotaxis Q5BJU7 rat S397-p 7979603 APPLVQPsPPVARAA intracellular localization cytoskeletal reorganization 19460862 4 2 0 +Nfya NFYA DNA-binding; Transcription factor P23708 18044 17 C|17 23.99 cM mouse K289-ac 4659501 AKLEAEGkIPKERRK CBFB_NFYA cell growth, induced; transcription, induced 18815279 1 1 0 +TCF3 E2A Cell development/differentiation; DNA-binding; Oncoprotein; Transcription factor P15923 6929 19p13.3 human T355-p 455166 NFSSSPStPVGSPQG activity, inhibited transcription, inhibited 19801649 3 4 25 +NDC80 HEC1 Cell cycle regulation O14777 10403 18p11.32 human S15-p 474511 SGGAGRLsMQELRSQ cell cycle regulation; cytoskeletal reorganization 17129782; 35878017; 36897279 3 5 0 +SLAMF1 SLAM Membrane protein, integral; Receptor, misc. Q13291 6504 1q23.3 human Y281-p 447633 EKKSLTIyAQVQKPG molecular association, regulation SHP-2(INDUCES); APCS(INDUCES) 11806999 2 9 741 +UHRF1 UHRF1 iso2 DNA-binding; EC 6.3.2.-; EC 6.3.2.19; Ligase; Transcription factor; UBIQUITIN LIGASE; Ubiquitin conjugating system; Ubiquitin ligase Q96T88-2 29128 19p13.3 human S652-p 471011 QQEGGFAsPRTGKGK molecular association, regulation 26299963 3 20 1 S652 phosphorylation showed only a modest (2-fold) reduction of binding affinity, but no direct interaction between S652 and USP7 +NRBF2 NRBF2 Autophagy; Nuclear receptor co-regulator; Transcription, coactivator/corepressor Q96F24 29982 10q21.3 human S120-p 476484 SPLSQKYsPSTEKCL NRBF2 molecular association, regulation; enzymatic activity, inhibited autophagy, induced ULK1(DISRUPTS); beclin 1(DISRUPTS); ATG13(DISRUPTS); ATG14(DISRUPTS); PIK3R4(INDUCES); PIK3C3(INDUCES); RB1CC1(DISRUPTS) 28059666 1 5 0 controls ULK1 complex association and PtdIns3K complex assembly, decreases PtdIns3K lipid kinase activity +UBA52-RPS27A-UBB-UBC ubiquitin Ubiquitin-like modifier P62988 2p16 human K27-ub 3931595 SDTIENVkAKIQDKE ubiquitin protein degradation; protein stabilization; molecular association, regulation; enzymatic activity, induced; phosphorylation; activity, induced; ubiquitination; intracellular localization; protein conformation cell differentiation, inhibited; cell cycle regulation; carcinogenesis, inhibited; cell growth, inhibited; transcription, induced; signaling pathway regulation; DNA repair, induced; autophagy, induced; transcription, inhibited CALCOCO2(INDUCES); SHP-1(DISRUPTS) 15466860; 30631154; 30741923; 31127032; 31304625; 31862882; 32476569; 34362877; 35238669; 35918322; 35982175; 36343628; 36563124 30 23 142 MRE11A promotes its exonuclease activity +SOX2 SOX2 Cell development/differentiation; DNA-binding; Transcription factor P48431 6657 3q26.33 human S251-p 6738002 VKSEASSsPPVVTSS protein stabilization; molecular association, regulation; ubiquitination cell differentiation, inhibited; carcinogenesis, induced; cell growth, induced; apoptosis, inhibited WWP2(DISRUPTS); CUL4A(DISRUPTS) 34193614; 37349645 4 13 0 inhibits ubiquitination +IBTK IBTK Protein kinase, regulatory subunit Q9P2D0 25998 6q14.1 human S1200-p 21358401 ASSLHSVsSKSFRDF activity, induced; molecular association, regulation; intracellular localization; enzymatic activity, induced Btk(DISRUPTS) 21482705 1 1 0 regulation of the Btk:IBTK complex, induce calcium mobilization and NFkB activation +GTF2A1 GTF2A1 Transcription, coactivator/corepressor P52655 2957 14q31.1 human S316-p 448629 VEEEPLNsEDDVSDE TFIIA transcription, induced 11278496 1 6 0 +DUSP6 DUSP6 EC 3.1.3.16; EC 3.1.3.48; Motility/polarity/chemotaxis; PHOSPHATASE; Protein phosphatase, dual-specificity Q16828 1848 12q21.33 human S197-p 455266 SATDSDGsPLSNSQP protein degradation 15632084 5 0 0 +Cacng2 Stargazin Channel, calcium; Membrane protein, integral; Membrane protein, multi-pass O88602 12300 15 E1|15 36.92 cM mouse S239-p 455315 RYQRRSRsSSRSTEP activity, induced; intracellular localization neural plasticity 15664178; 20670832; 24882000 7 0 0 AMPAR immobilization in synaptic membrane; enhances AMPA receptor responses and is required for long-term potentiation; regulates synaptic scaling +KIF11 KIF11 Microtubule-binding; Motor P52732 3832 10q23.33 human Y231-p 14567513 AATLMNAySSRSHSV Kinesin cytoskeletal reorganization 28646493 1 2 1 spindle morphology +MRE11 MRE11A Cell cycle regulation; DNA repair, damage; DNA-binding; Deoxyribonuclease P49959 4361 11q21 human S678-p 460789 SSKIMSQsQVSKGVD protein degradation; molecular association, regulation DNA repair, induced; chromatin organization, altered C1QBP(DISRUPTS); NBS1(INDUCES) DNA(INDUCES); DNA(DISRUPTS) 19709933; 26240375; 31353207 3 6 10 +CD4 CD4 Cell surface; Membrane protein, integral P01730 920 12p13.31 human S440-p 469618 SQIKRLLsEKKTCQC Tcell_CD4_C intracellular localization 15494497 1 0 0 +SUV39H1 SUV39H1 Amino Acid Metabolism - lysine degradation; EC 2.1.1.43; METHYLTRANSFERASE; Methyltransferase; Methyltransferase, protein lysine O43463 6839 Xp11.23 human S391-p 469894 GLAGLPGsPKKRVRI molecular association, regulation cell cycle regulation DNA(DISRUPTS) 24728993 1 40 20 disassociation of SUV39H, leading to H3K9m3 reduction, and heterochromatin replication during cell cycle progression +Runx1 AML1 DNA-binding; Oncoprotein; Transcription factor Q03347 12394 16 C4|16 53.7 cM mouse Y260-p 51211403 SYDQSYQyLGSITSS activity, induced; protein stabilization transcription, induced HDAC1(DISRUPTS) DNA(INDUCES) 26598521 1 0 0 +NINL Nlp Cell cycle regulation; Microtubule-binding Q9Y2I6 22981 20p11.21 human S589-p 17490600 NRHSPSWsPDGRRRQ protein degradation; ubiquitination; intracellular localization 20890132 1 0 0 +GCM1 GCM1 DNA-binding; Transcription factor Q9NP62 8521 6p12.1 human S326-p 7979601 PLTSWPCsFSPSQNS protein degradation; molecular association, regulation; ubiquitination FBXW2(INDUCES) 19416964 1 0 0 +SKI SKI Cell cycle regulation; Oncoprotein; Transcription, coactivator/corepressor; Ubiquitin conjugating system P12755 6497 1p36.33-p36.32 human S326-p 41656200 RRVPRVSsEPPASIR protein degradation cell cycle regulation; carcinogenesis, induced 26138431 1 1 0 plays a role in chromosomal segregation +SLC6A1 SLC6A1 Membrane protein, integral; Membrane protein, multi-pass; Transporter; Transporter, SLC family P30531 6529 3p25.3 human Y317-p 11382800 NSFHNNVyRDSIIVC SNF activity, induced; receptor internalization, altered; intracellular localization 11555659 1 0 0 +CCNT1 CCNT1 Cell cycle regulation; Transcription initiation complex O60563 904 12q13.11-q13.12 human K386-ac 25174700 SKSVPSAkVSLKEYR molecular association, regulation; enzymatic activity, induced transcription, induced BCDIN3(DISRUPTS); HEXIM1(DISRUPTS); BRD4(INDUCES) RNA(DISRUPTS) 19387490; 22084242 3 1 0 Interaction with BRD4 disrupts interaction with HEXIM1 and 7SK snRNA; enhances CDK9/cyclin T1 transcriptional activity, disrupting HEXIM1 and BCDIN3 association +Dok2 DOK2 Adaptor/scaffold O70469 13449 14 D2|14 36.71 cM mouse Y402-p 455779 DWPQATEyDNVILKK molecular association, regulation apoptosis, induced CSK(INDUCES) 15831486 1 0 44 Dok2 constitutively interacts with Src. Induced binding of Csk to Dok2 allows Csk to act on Src. +NOTCH1 Notch 1 Membrane protein, integral; Motility/polarity/chemotaxis; Oncoprotein; Receptor, misc.; Transcription factor P46531 4851 9q34.3 human S2522-p 467288 ESPDQWSsSSPHSNV protein degradation; receptor inactivation, altered 16880534 1 0 0 Alanine mutation of 4 serines (S2522/S2523/S2524/S2525) causes increased protein stability. +ID3 ID3 DNA-binding; Transcription, coactivator/corepressor Q02535 3399 1p36.12 human S5-p 451011 ___MKALsPVRGCYE protein stabilization cell cycle regulation; transcription, altered 25090023; 9372912 2 7 9 Cdk-dependent phosphorylation inactivates the G1-to-S cell cycle regulatory function of Id3 protein.; regulates vascular EC survival and growth of microvascular lesions +SORT1 SORT1 Membrane protein, integral; Receptor, misc. Q99523 6272 1p13.3|1p21.3-p13.1 human S793-p 3823097 RFLVHRYsVLQQHAE molecular association, regulation; intracellular localization AP1AR(DISRUPTS) 31767632 3 8 0 +EPHA3 EphA3 EC 2.7.10.1; KINASE; Kinase, protein; Membrane protein, integral; Protein kinase, TK; Protein kinase, tyrosine (receptor) P29320 2042 3p11.1 human Y596-p 449912 KLPGLRTyVDPHTYE EphA2_TM molecular association, regulation; protein conformation; enzymatic activity, induced cytoskeletal reorganization; cell adhesion, altered CRK(INDUCES) 11870224; 18547520 3 6 26 +AXIN1 axin 1 Adaptor/scaffold; Tumor suppressor O15169 8312 16p13.3 human S469-p 25802104 AHEENPEsILDEHVQ Axin_b-cat_bind transcription, inhibited GSK3B(INDUCES) 17318175 1 3 0 +Rela NFkB-p65 DNA-binding; Nuclear receptor co-regulator; Transcription factor Q04207 19697 19 A|19 4.34 cM mouse T504-p 455490 EAITRLVtGSQRPPD cell motility, inhibited 26853469 4 0 0 higher levels of cell proliferation with T505A mutant mouse +LATS2 LATS2 EC 2.7.11.1; KINASE; Kinase, protein; Nuclear receptor co-regulator; Protein kinase, AGC; Protein kinase, Ser/Thr (non-receptor); Tumor suppressor Q9NRM7 26524 13q12.11 human T436-gl 1869341904 PNTVTAVtAAHILHP molecular association, regulation; enzymatic activity, inhibited; phosphorylation carcinogenesis, induced; cell growth, induced; signaling pathway regulation MOB1B(DISRUPTS) 32513743 1 1 0 inhibits phosphorylation at LATS2-S872 and T1041; disrupts the hippo-pathway +IRF5 IRF5 DNA-binding; Transcription factor Q13568 3663 7q32.1 human Y335-p 25742049 QLQGQDLyAIRLCQC IRF-3 molecular association, regulation; ubiquitination transcription, inhibited LYN(INDUCES) 27521268 1 1 2 inhibition of IRF5 activation by Lyn requires their physical Interaction, Lyn inhibits IRF5 ubiquitination and phosphorylation by protecting IRF5 from each of PTM enzymes +POU3F2 Oct7 DNA-binding; Motility/polarity/chemotaxis; Transcription factor P20265 5454 6q16.1 human S96-p 1868139201 DGSPWSTsPLGQPDI DNA repair, altered; signaling pathway regulation DNA(INDUCES) 30804224 1 0 0 +Traf3 TRAF3 UBIQUITIN LIGASE; Ubiquitin conjugating system; Ubiquitin ligase Q60803 22031 12 F1|12 60.94 cM mouse S29-p 23154950 QPDRGAGsVLVPEQG cell growth, induced; apoptosis, inhibited; transcription, induced; signaling pathway regulation 34255829 1 2 2 induces NIK stabilization and NF-kB signaling +CALU CALU iso15 Calcium-binding; Secreted; Secreted, signal peptide O43852-15 813 7q32.1 human T73-p 29606705 MYSHDGNtDEPEWVK intracellular localization transcription, induced; cytoskeletal reorganization 24136234 1 0 0 nuclear localization, facilitates filopodia formation +VPS4A VPS4A EC 3.6.4.6; Vesicle Q9UN37 27183 16q22.1 human K23-ub 1881849300 ATEEDKAkNYEEALR molecular association, regulation; ubiquitination; enzymatic activity, induced CHMP1B(INDUCES) 35044214 1 0 0 interaction after HCV infection, enhances VPS4A ATPase activity, release of HCV particles +AQP4 AQP4 Channel, misc.; Membrane protein, integral; Membrane protein, multi-pass; Transporter; Transporter, aquaporin family P55087 361 18q11.2 human S180-p 467301 TIFASCDsKRTDVTG MIP activity, inhibited cell motility, altered 19761816 4 0 0 mutation of this site (S180A) increases invasion of tumor cells; reduces water permeability +APLNR APLNR GPCR, family 1; Membrane protein, integral; Membrane protein, multi-pass; Receptor, GPCR P35414 187 11q12.1 human S339-p 1870435803 AGTSHSSsGEKSASY activity, induced; receptor internalization, induced; molecular association, regulation GRK2(DISRUPTS) 32863206 0 1 0 ERK1/2 activation +LIN28A LIN28A Nucleolus; RNA-binding; Translation Q9H9Z2 79727 1p36.11 human K15-sm 1877427002 QFAGGCAkAAEEAPE molecular association, regulation carcinogenesis, induced; cell motility, induced; cell growth, induced 32333719 1 0 0 binding affinity to pre-let-7, suppresses let-7 miRNA biogenesis +TP73 p73 DNA-binding; Transcription factor; Tumor suppressor O15350 7161 1p36.32 human S235-p 23481800 DPVTGRQsVVVPYEP P53 molecular association, regulation; intracellular localization cell cycle regulation; cell growth, induced; apoptosis, inhibited; transcription, inhibited CDC20(DISRUPTS); HSPA9B(INDUCES) DNA(DISRUPTS) 22340593 1 0 0 +PRNP PRNP Membrane protein, GPI anchor; Microtubule-binding P04156 5621 20p13 human Y145-p 38520206 IIHFGSDyEDRYYRE Prion protein conformation 25572400 1 0 0 exacerbate PRNP mutant conversion +CYP2E1 CYP2E1 EC 1.14.13.n7; Endoplasmic reticulum; Lipid Metabolism - arachidonic acid; Lipid Metabolism - linoleic acid; Mitochondrial; Oxidoreductase; Xenobiotic Metabolism - drug metabolism - cytochrome P450; Xenobiotic Metabolism - metabolism by cytochrome P450 P05181 1571 10q26.3 human R379-me 1878196104 ATRDTIFrGYLIPKG protein degradation 31077594 1 1 0 me-CYP2E1 is reduced in Mat1a KO liver mitochondria; down-regulation of CYP2E1 protein level requires R379 methylation +Rb1 Rb Nuclear receptor co-regulator; Oncoprotein; Transcription, coactivator/corepressor; Tumor suppressor P33568 24708 15q11 rat S787-p 447979 SPYKFSSsPLRIPGG Rb_C molecular association, regulation transcription, inhibited HDAC1(INDUCES) 19081374 52 17 94 +LLGL1 LLGL1 Cell adhesion; Cytoskeletal; Motility/polarity/chemotaxis Q15334 3996 17p11.2 human S655-p 449915 GPLSRVKsLKKSLRQ intracellular localization 34717957 2 1 4 +EMD emerin Cytoskeletal; Membrane protein, integral P50402 2010 Xq28 human Y161-p 449652 MYGRDSAyQSITHYR molecular association, regulation BAF(INDUCES) 19789182 1 12 257 +APOBEC3B APOBEC3B EC 3.5.4.-; Hydrolase; RNA-binding Q9UH17 9582 22q13.1 human T214-p 1869951800 LVLRRRQtYLCYEVE NAD2 enzymatic activity, inhibited carcinogenesis, altered DNA(DISRUPTS) 31165764 1 0 0 regulates anti-retroviral and anti-retrotransposition activity +MELK MELK EC 2.7.10.2; EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, CAMK; Protein kinase, Ser/Thr (non-receptor); Protein kinase, tyrosine (non-receptor); RNA splicing Q14680 9833 9p13.2 human T167-p 456039 NKDYHLQtCCGSLAY Pkinase enzymatic activity, induced 16216881 3 1 0 +IRF1 IRF1 Transcription factor; Tumor suppressor P10914 3659 5q31.1 human K78-ub 31914114 EPDPKTWkANFRCAM IRF protein degradation; molecular association, regulation DNA(DISRUPTS) 23134341 1 3 0 +CDK11B CDK11B iso12 Apoptosis; Cell cycle regulation; EC 2.7.11.22; KINASE; Kinase, protein; Motility/polarity/chemotaxis; Protein kinase, CMGC; Protein kinase, Ser/Thr (non-receptor) P21127-12 984 1p36.33 human T370-p 17671300 KHEYFREtPLPIDPS molecular association, regulation; enzymatic activity, induced apoptosis, altered CDK11A iso10(INDUCES) 21078675 1 1 0 T370A mutant fails to repress the transactivation of androgen receptor and to enhance the cell apoptosis +PSMC5 RPT6 Nuclear receptor co-regulator; Proteasome complex; Ubiquitin conjugating system P62195 5705 17q23.3 human S120-p 483970 RVALRNDsYTLHKIL Prot_ATP_ID_OB activity, induced; molecular association, regulation 17565987; 23275441 11 7 0 proteosome activity enhanced,delays formation HTT aggregates; S120A mutation blocks proteasome function in vivo +Rela NFkB-p65 DNA-binding; Nuclear receptor co-regulator; Transcription factor Q7TQN4 309165 1q43 rat S276-p 447798 SMQLRRPsDRELSEP RHD_dimer cell differentiation, altered; apoptosis, inhibited; transcription, induced 18385332; 21550382 90 0 0 induces cell survival; nerve myelination +PRKCD PKCD EC 2.7.11.13; KINASE; Kinase, protein; Nuclear receptor co-regulator; Protein kinase, AGC; Protein kinase, Ser/Thr (non-receptor); Protein kinase, tyrosine (non-receptor); Tumor suppressor Q05655 5580 3p21.1 human Y313-p 447573 SSEPVGIyQGFEKKT sumoylation; molecular association, regulation; protein conformation; enzymatic activity, altered; phosphorylation carcinogenesis, induced; apoptosis, altered; cell motility, induced; cell growth, induced; signaling pathway regulation; transcription, inhibited 16982614; 17126298; 21730054; 24260357; 25755284; 26876198; 34089566; 36862682 44 60 1707 +CDK5R1 CDK5R1 Protein kinase, regulatory subunit Q15078 8851 17q11.2 human S91-p 12607404 ENLKKSLsCANLSTF CDK5_activator protein degradation; molecular association, regulation; ubiquitination PJA2(INDUCES) 24561619 4 0 0 regulates calcium entry in the Beta-cell and insulin secretion +AR AR DNA-binding; Nuclear receptor; Transcription factor P10275 367 Xq12 human Y269-p 478250 QLRGDCMyAPLLGVP Androgen_recep acetylation; molecular association, regulation; intracellular localization carcinogenesis, induced; cell growth, induced; transcription, induced; cell growth, altered p300(INDUCES) DNA(INDUCES) 17494760; 20623637; 25950519; 28055971; 35704598 7 2 0 primes acetylation at K610 +PDGFRB PDGFRB EC 2.7.10.1; KINASE; Kinase, protein; Membrane protein, integral; Oncoprotein; Protein kinase, TK; Protein kinase, tyrosine (receptor) P09619 5159 5q32 human Y740-p 447520 TGESDGGyMDMSKDE PK_Tyr_Ser-Thr activity, induced; molecular association, regulation; enzymatic activity, induced cell cycle regulation PIK3C2A(INDUCES); SHC1(INDUCES); SHP-1(INDUCES); PIK3R1(INDUCES); PIK3CA(INDUCES) 1314164; 1375321; 17403678; 7774014; 7935391; 8195171; 8290276; 9452499 11 2 7 +RPS6KA4 MSK2 EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, AGC; Protein kinase, Ser/Thr (non-receptor) O75676 8986 11q13.1 human T568-p 450047 SPGVPMQtPCFTLQY Pkinase enzymatic activity, induced 10806207 1 0 0 +RBBP8 CtIP EC 3.1.-.-; Transcription, coactivator/corepressor Q99708 5932 18q11.2 human S327-p 452473 ELPTRVSsPVFGATS molecular association, regulation; phosphorylation cell cycle regulation BRCA1(DISRUPTS); PLK1(INDUCES); BRCA1(INDUCES) 15485915; 16101277; 30202980 6 22 1 stimulates binding of CtIP to PBD domain of PLK1 and its further phosphorylation by PLK1 at S723; Phosphorylation required for G2/M transition checkpoint. +SERPINF1 PEDF Inhibitor; Secreted; Secreted, signal peptide P36955 5176 17p13.3 human S227-p 455233 KFDSRKTsLEDFYLD Serpin molecular association, regulation apoptosis, altered; carcinogenesis, altered; cell motility, altered LEPR(INDUCES) 21059648 3 1 0 +CEBPB C/EBP-beta DNA-binding; Motility/polarity/chemotaxis; Transcription factor P17676 1051 20q13.13 human K264-ac 458939 SQVKSKAkKTVDKHS molecular association, regulation transcription, inhibited DNA(DISRUPTS) 12574125 4 0 0 +Nfatc2 NFAT1 DNA-binding; Transcription factor Q60591 18019 2 H3|2 88.91 cM mouse S99-p 447854 IGFQNFLsPVKPAGA transcription, inhibited 11030334 0 3 1 +EIF4G3 EIF4G3 RNA-binding; Translation; Translation initiation O43432 8672 1p36.12 human S1156-p 2915400 NTFMRGGsSKDLLDN molecular association, regulation translation, induced EIF4E(INDUCES) 22514323 2 13 0 +MAP2K1 MEK1 EC 2.7.12.2; KINASE; Kinase, protein; Protein kinase, STE; Protein kinase, dual-specificity (non-receptor) Q02750 5604 15q22.31 human S222-p 448513 LIDSMANsFVGTRSY Pkinase intracellular localization; protein conformation; phosphorylation; enzymatic activity, induced cell cycle regulation; carcinogenesis, induced; cell growth, induced; transcription, induced; signaling pathway regulation; cell growth, altered 12466969; 12506122; 12609989; 16585161; 17667937; 19106095; 21893193; 24681949; 27323830; 32076487; 33789117; 33808483; 34470822; 34642304; 7731726; 8621729 117 20 203 +FLOT1 FLOT1 Adaptor/scaffold O75955 10211 6p21.33 human Y160-p 462262 DIHDDQDyLHSLGKA Band_7 endocytosis, altered 19258392 1 3 48 regulates FLOT1 internalization +Shisa7 SHISA7 Membrane protein, integral Q8C3Q5 232813 7|7 A1 mouse S405-p 3989799 PNPRRVMsQEHLLGD intracellular localization neural plasticity; exocytosis, induced 33761345; 35534528 2 1 5 +ERBB3 HER3 EC 2.7.10.1; KINASE; Kinase, protein; Membrane protein, integral; Oncoprotein; Protein kinase, TK; Protein kinase, tyrosine (receptor) P21860 2065 12q13.2 human Y1276-p 449857 GGGPGGDyAAMGACP molecular association, regulation carcinogenesis, induced; cell motility, induced PIK3R2(INDUCES); PIK3R1(INDUCES) 16729043; 21725367 3 6 57 chemotaxis and invasion +PPARA PPAR-alpha DNA-binding; Nuclear receptor; UBIQUITIN LIGASE Q07869 5465 22q13.31 human S6-p 1789804 __MVDTEsPLCPLSP transcription, inhibited 18079279; 21224484 2 0 0 +HRH1 H1R GPCR, family 1; Membrane protein, integral; Membrane protein, multi-pass; Receptor, GPCR P35367 3269 3p25.3 human T140-p 453406 LRYLKYRtKTRASAT 7tm_1 receptor desensitization, altered; receptor internalization, altered 15107581; 15328002 2 0 0 +Nos1 nNOS Amino Acid Metabolism - arginine and proline; EC 1.14.13.39; Oxidoreductase P29476 24598 12q16 rat S293-p 56689901 QSPTKNGsPSRCPRF protein conformation 27296112 1 0 0 may disrupt the formation of nNOS dimers +IRF1 IRF1 Transcription factor; Tumor suppressor P10914 3659 5q31.1 human S215-p 31839602 DLYNFQVsPMPSTSE molecular association, regulation; activity, inhibited transcription, inhibited NFkB-p65(DISRUPTS) 24396068 1 0 0 Phosphorylation impairs iNFkB-p65 interaction and PCAF mediated acetylation K310 -suppression of IFN-beta production +PKM PKM Carbohydrate Metabolism - glycolysis and gluconeogenesis; Carbohydrate Metabolism - pyruvate; EC 2.7.1.40; KINASE; Kinase, other; Mitochondrial; Nucleotide Metabolism - purine P14618 5315 15q23 human S362-gl 1879953200 GADCIMLsGETAKGD enzymatic activity, inhibited cell growth, induced PKM(DISRUPTS) 31501520 1 0 0 O-GlcNAcylation of PKM inhibits its catalytic activity and tetramerization +Srpk1 SRPK1 EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, CMGC; Protein kinase, Ser/Thr (non-receptor) O70551 20815 17|17 A3.3 mouse S51-p 456012 QEEEILGsDDDEQED chromatin organization, altered 36765089 2 49 23 +NCOA2 SRC-2 Motility/polarity/chemotaxis; Nuclear receptor co-regulator; Transcription, coactivator/corepressor Q15596 10499 8q13.3 human K780-ac 466316 TDPASNTkLIAMKTE DUF4927 activity, inhibited transcription, inhibited; signaling pathway regulation 31851938 1 7 41 PPAR-gamma inhibition +USP14 USP14 DEUBIQUITINASE; EC 3.4.19.12; Protease; Ubiquitin conjugating system; Ubiquitin-specific protease P54578 9097 18p11.32 human S432-p 31083558 THQGRSSsSGHYVSW UCH protein degradation; ubiquitination 26523394 1 1 0 regulate the UPS in a ubiquitin-dependent manner, regulate global 273 protein degradation +Wnk4 WNK4 EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, Other; Protein kinase, Ser/Thr (non-receptor) Q80UE6 69847 11|11 D mouse K154-ub 40323309 RRREQEEkEDTETQA protein degradation 23576762 1 1 0 regulates electrolyte homeostasis and involved in Pseudohypoaldosteronism type II (PHAII) pathogenesis +NR1H2 LXR-beta Nuclear receptor P55055 7376 19q13.33 human K409-sm 12004410 LLSYTRIkRPQDQLR Hormone_recep molecular association, regulation transcription, inhibited coronin 2A(INDUCES) DNA(INDUCES) 17218271; 21331046 2 0 0 +PRKAA1 AMPKA1 Autophagy; EC 2.7.11.1; EC 2.7.11.26; EC 2.7.11.27; EC 2.7.11.31; KINASE; Kinase, protein; Protein kinase, CAMK; Protein kinase, Ser/Thr (non-receptor) Q13131 5562 5p13.1 human T183-p 448786 SDGEFLRtSCGSPNY Pkinase intracellular localization; phosphorylation; enzymatic activity, induced cell differentiation, inhibited; cell cycle regulation; carcinogenesis, induced; cell growth, inhibited; apoptosis, induced; transcription, induced; signaling pathway regulation; autophagy, induced; apoptosis, inhibited 12391032; 14511394; 14614828; 14985505; 15980064; 17082196; 19414597; 19884317; 21918180; 22039048; 26771234; 27864418; 28778925; 30022161; 30309849; 30413706; 34807950; 35413286; 35670018 228 16 33 +MCL1 MCL1 Apoptosis; Channel, misc.; Inhibitor; Membrane protein, integral; Mitochondrial Q07820 4170 1q21.2 human K40-ac 1875365200 GRLLATEkEASARRE protein stabilization; molecular association, regulation; ubiquitination carcinogenesis, induced; cell growth, induced; apoptosis, inhibited USP9X(INDUCES) 34758305 1 1 0 acetylation decreases ubiquitination; phosphorylation impairs interaction with USPX and increases poly ubiquitination +Syn1 SYN1 Vesicle O88935 20964 X A1.3|X 16.37 cM mouse S551-p 451574 PAARPPAsPSPQRQA cytoskeletal reorganization; signaling pathway regulation 25463523; 30016727 10 18 10 protects against ischemic injury and cell death; OGD induces morphological damage of neurites in cortical neurons; multiple signaling pathways converge onto SynI and regulated by phosphorylation, hippocampal-dependent learning de?cits +TPPP TPPP Cytoskeletal O94811 11076 5p15.33 human S18-p 456612 ANRTPPKsPGDPSKD cytoskeletal reorganization 17693641 1 25 9 ERK2 phosphorylation of TPPP induces formation of tubulin assemblies. +RAD9A RAD9A Apoptosis; Cell cycle regulation; DNA replication; Deoxyribonuclease; EC 3.1.11.2 Q99638 5883 11q13.2 human S341-p 449817 PKSPGPHsEEEDEAE molecular association, regulation; intracellular localization TOPBP1(INDUCES) 20545769; 25091155; 26088138 5 7 7 +NCOA3 SRC-3 ACETYLTRANSFERASE; Acetyltransferase; EC 2.3.1.48; Motility/polarity/chemotaxis; Nuclear receptor co-regulator; Transcription, coactivator/corepressor Q9Y6Q9 8202 20q13.12 human T1064-p 4252807 LHTLLSNtDATGLEE Nuc_rec_co-act protein stabilization; molecular association, regulation PSMA3(DISRUPTS) 18313384 1 0 0 some subset of these 8 residues +SSTR5 SSTR5 Cell cycle regulation; GPCR, family 1; Membrane protein, integral; Membrane protein, multi-pass; Receptor, GPCR P35346 6755 16p13.3 human S242-p 1779801 VGCVRRRsERKVTRM 7tm_1 activity, induced; molecular association, regulation; receptor internalization, altered ARRB2(INDUCES) 18096696 1 0 0 +PAK1 PAK1 EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, STE; Protein kinase, Ser/Thr (non-receptor) Q13153 5058 11q13.5-q14.1 human S204-p 448173 TKSVYTRsVIEPLPV molecular association, regulation; intracellular localization; protein conformation; phosphorylation; enzymatic activity, induced carcinogenesis, induced; cell motility, induced; cell growth, induced; cell motility, altered; cell adhesion, altered; signaling pathway regulation PXN(DISRUPTS) 19574218; 30664689; 31660987 18 16 0 phosphorylation of NFkB (activation); Inhibitors decreased the tumor growth by inhibiting the phosphorylation; recruitment to the plasma membrane +MDM2 MDM2 EC 6.3.2.-; EC 6.3.2.19; Inhibitor; Ligase; NEDDYLATION LIGASE; Neddylation Ligase; Nucleolus; Oncoprotein; UBIQUITIN LIGASE; Ubiquitin conjugating system; Ubiquitin ligase Q00987 4193 12q15 human S246-p 454925 DSVSDQFsVEFEVES activity, induced 12167711 3 0 0 promotes p53 degradation +Nedd4l NEDD4L EC 6.3.2.-; EC 6.3.2.19; Ligase; UBIQUITIN LIGASE; Ubiquitin conjugating system; Ubiquitin ligase Q8CFI0 83814 18|18 E1 mouse S477-p 453440 IRRPRSLsSPTVTLS protein stabilization; molecular association, regulation; ubiquitination; intracellular localization 14-3-3 beta(INDUCES); 14-3-3 epsilon(INDUCES); CFTR(DISRUPTS) 16613846; 21900244; 25384981 16 64 53 regulates intracellular localization, prevents ubiquitination and degradation of CFTR +Stat5b STAT5B DNA-binding; Oncoprotein; Transcription factor P42232 20851 11 D|11 63.63 cM mouse Y699-p 448198 TAKAADGyVKPQIKQ activity, induced carcinogenesis, induced; transcription, induced; transcription, altered; cell growth, altered 10706883; 12091337; 34535769 45 45 2242 +Homer3 HOMER3 Adaptor/scaffold Q99JP6 26558 8|8 B3.3 mouse S159-p 477736 EKLFRSQsADTPGPT molecular association, regulation GluR5(DISRUPTS) 26670047 1 31 42 circuit hyperexcitability in fragile X syndrome +Tbk1 TBK1 EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, Other; Protein kinase, Ser/Thr (non-receptor) Q9WUN2 56480 10|10 D2 mouse K30-ub 31033007 VFRGRHKkTGDLYAV Pkinase autophagy, induced 33164878 3 1 0 Parkin mediated mitophagy +Cnr1 CNR1 GPCR, family 1; Membrane protein, integral; Membrane protein, multi-pass; Receptor, GPCR P47746 12801 4 A5|4 16.28 cM mouse T466-p 22342306 KVTMSVStDTSAEAL receptor desensitization, induced 22014214 1 0 1 +Stat3 STAT3 DNA-binding; Motility/polarity/chemotaxis; Nuclear receptor co-regulator; Transcription factor P42227 20848 11 D|11 63.82 cM mouse R31-me 15343402 DSFPMELrQFLAPWI STAT_int phosphorylation signaling pathway regulation 20798359 1 0 0 decrease in STAT3 phosphorylation, regulates Leptin signaling and energy homeostasis +SMAD3 SMAD3 DNA-binding; Nuclear receptor co-regulator; Transcription factor P84022 4088 15q22.33 human K333-ac 1876739200 WHPATVCkIPPGCNL MH2 transcription, induced 32305562 2 0 0 +APP APP iso4 Apoptosis; Cell surface; Membrane protein, integral; Receptor, misc.; Transcription factor P05067-4 351 21q21.3 human S675-p 1869465803 TPEERHLsKMQQNGY APP_amyloid protein processing 31604820 1 0 0 +DNMT1 DNMT1 Amino Acid Metabolism - cysteine and methionine; Cell development/differentiation; EC 2.1.1.37; METHYLTRANSFERASE; Methyltransferase; Methyltransferase, DNA; Transcription regulation P26358 1786 19p13.2 human K749-ac 25171013 GKKSYYKkVCIDAET cell cycle regulation 21947282 1 1 0 +Ncf1 p47phox EC 1.-.-.-; Oxidoreductase F1M707 114553 12q12 rat S316-p 451725 AQSIHQRsRKRLSQD NECFESHC neural plasticity 30181899 14 0 0 phosphorylation is required for LTD synaptic plasticity +IRS4 IRS4 Adaptor/scaffold O14654 8471 Xq22.3 human Y828-p 456293 GQNDNSEyVPMLPGK cell cycle regulation; carcinogenesis, induced; cell growth, induced 35550247 1 4 24 +DSP Desmoplakin Cell adhesion; Cytoskeletal; Motility/polarity/chemotaxis P15924 1832 6p24.3 human R2834-me 34833301 SGSRSGSrSGSRSGS molecular association, regulation cell adhesion, induced 25733715 1 1 0 recruitment into desmosomes, R2834H mutant impaired recruitment and ablated phosphorylation of six serine residues within the GSK3 cascades. facilitates GSK3 interactions with Desmoplakin +TBK1 TBK1 EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, Other; Protein kinase, Ser/Thr (non-receptor) Q9UHD2 29110 12q14.2 human K401-ub 31033006 YEKISLPkVHPRYDL TBK1_CCD1 ubiquitination; intracellular localization; phosphorylation; enzymatic activity, induced transcription, induced; signaling pathway regulation 23453972; 27538435 3 1 0 ubquitination of one of these sites is required for S172 phosphorylation ; TBK1 trans-autophosphorylation phosphorylation at S172, enhances TBK1-induced phosphorylation of IRF3, regulation of downstream-signaling in innate immunity after RNA virus infection +RGS2 RGS2 GAP; GAP, RGS P41220 5997 1q31.2 human S46-p 10772900 KDWKTRLsYFLQNSS activity, induced; molecular association, regulation; intracellular localization G-alpha i3(INDUCES) 14608379; 24777815 2 0 0 RGS2 phosphorylation increases G-alpha GTPase activity, and association with membrane fraction. ; inhibits CPA-induced hydrolysis +Prkce PKCE EC 2.7.11.13; KINASE; Kinase, protein; Protein kinase, AGC; Protein kinase, Ser/Thr (non-receptor) P09216 29340 6q12 rat S729-p 448789 QEEFKGFsYFGEDLM Pkinase_C intracellular localization; enzymatic activity, induced 15886222 20 17 7 +TRIM32 TRIM32 EC 6.3.2.-; EC 6.3.2.19; Ligase; UBIQUITIN LIGASE; Ubiquitin conjugating system; Ubiquitin ligase Q13049 22954 9q33.1 human Y528-p 1876282804 CDAEGTVyFTQGLGL molecular association, regulation carcinogenesis, induced; cell growth, induced; transcription, induced STAT3(INDUCES) 35091679 1 0 0 binding to STAT3 inhibits STAT3-TC45 binding thus inducing STAT3 phosphorylation +FUS hnRNP P2 DNA-binding; Nuclear receptor co-regulator; Oncoprotein; RNA splicing; RNA-binding; SUMO LIGASE P35637 2521 16p11.2 human T68-p 179463704 SQNTGYGtQSTPQGY molecular association, regulation 28942918 2 1 0 strongly reduced the effects of DNA-PK treatment on both hydrogel binding and droplet formation +Cacng2 Stargazin Channel, calcium; Membrane protein, integral; Membrane protein, multi-pass O88602 12300 15 E1|15 36.92 cM mouse Y229-p 11025597 AITRIPSyRYRYQRR molecular association, regulation ARC(DISRUPTS) 25864631 1 0 1 +PAX3/FOXO1 PAX3-FOXO1 AAC50053 2308 13q14.11 human S503-p 37038800 PRTSSNAsTISGRLS protein stabilization cell growth, induced 25398439 1 1 0 +H3C1 H3 DNA-binding P68431 8350 6p22.2 human K122-ac 3652700 KRVTIMPkDIQLARR Histone molecular association, regulation chromatin organization, altered polybromo 1(INDUCES); SMAD4(INDUCES); SMAD2(INDUCES); SMAD3(INDUCES) DNA(DISRUPTS) 19520870; 20368734; 31815277 4 7 3 acetylation facilitates nucleosome repositioning; varying site specificity binding for each bromodomain 1-6 +Ikzf1 Ikaros C2H2-type zinc finger protein; DNA-binding; Transcription factor Q03267 22778 11 A1|11 7.02 cM mouse K58-sm 3609102 RGMGSNVkVETQSDE molecular association, regulation transcription, induced SIN3A(DISRUPTS); SIN3B(DISRUPTS); CHD-4(DISRUPTS); CTBP1(DISRUPTS) 15767674 2 0 0 +DAZAP1 DAZAP1 Motility/polarity/chemotaxis; RNA-binding Q96EP5 26528 19p13.3 human K150-ac 25171021 VMIYDAEkQRPRGFG RRM_1 intracellular localization 22001406 1 0 0 +LMNA lamin A/C Cytoskeletal P02545 4000 1q22 human Y45-p 55369404 LNDRLAVyIDRVRSL Filament molecular association, regulation; intracellular localization chromatin organization, altered; cell motility, induced; DNA repair, inhibited lamin A/C(DISRUPTS) 34385357 1 3 0 +CSNK2A1 CK2A1 EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, Other; Protein kinase, Ser/Thr (non-receptor) P68400 1457 20p13 human S362-p 449986 ISSVPTPsPLGPLAG molecular association, regulation; enzymatic activity, induced CK2A1(INDUCES); PGK1(INDUCES) 19941816; 30392930; 36646788 5 1 0 +Ssb SSB Transcription initiation complex P32067 20823 2 C2|2 40.95 cM mouse S199-p 2862901 KNEERKQsKVEAKLK molecular association, regulation RNA(INDUCES) 18257391 1 0 0 +PSEN1 PSEN1 Cell surface; EC 3.4.23.-; Membrane protein, integral; Membrane protein, multi-pass; Mitochondrial; Protease P49768 5663 14q24.2 human T74-p 62906104 EEEDEELtLKYGAKH protein conformation 28132667 1 0 0 PS1 pathogenic conformational shift +Rem1 REM1 G protein; G protein, monomeric; G protein, monomeric, RGK O35929 19700 2|2 H1 mouse S262-p 1211201 PSPRRRAsLGQRARR intracellular localization 17605760 1 0 0 +STMN1 STMN1 Cytoskeletal P16949 3925 1p36.11 human S25-p 448555 QAFELILsPRSKESV Stathmin protein stabilization; molecular association, regulation; activity, inhibited; phosphorylation cell cycle regulation; carcinogenesis, inhibited; cell growth, inhibited; apoptosis, induced; cell motility, induced; cell motility, inhibited; signaling pathway regulation; cell growth, induced; cytoskeletal reorganization TUBA1A(DISRUPTS); TUBB(DISRUPTS); TUBA1A(INDUCES); RNF12(DISRUPTS); GRP78(INDUCES) 11015208; 20110360; 23230143; 27130664; 30628717; 30786936; 31546234; 35581193; 7775478; 9271428; 9712920 52 122 91 Stathmin hyperphosphorylation leads to microtubule stability. +Gorasp2 GRASP55 Motility/polarity/chemotaxis; Vesicle Q9R064 113961 3q22 rat T225-p 470123 QMTGTPItPLKDGFT molecular association, regulation cell cycle regulation; cytoskeletal reorganization GRASP55(DISRUPTS) 18385516; 20083603 4 33 6 inhibits Golgi stack formation in interphase cells and enhances Golgi fragmentation in mitotic cells +Mcm3ap GANP ACETYLTRANSFERASE; Acetyltransferase; Karyopherin Q9WUU9 54387 10|10 C1 mouse S502-p 448619 FWHKKKIsPSKKLFP enzymatic activity, induced 11526238 1 4 0 Phosphorylation of this site appears to correlate with higher DNA-primase activity +Cd19 CD19 Cell surface; Membrane protein, integral P25918 12478 7 F3|7 69.01 cM mouse Y493-p 447638 SSLGSQSyEDMRGIL activity, induced; molecular association, regulation cell differentiation, altered PIK3R1(INDUCES) 12387743; 18025150 6 4 15 regulate Akt activation and B-cell differentiation through binding to PI3KR1 +ALK ALK EC 2.7.10.1; KINASE; Kinase, protein; Membrane protein, integral; Oncoprotein; Protein kinase, TK; Protein kinase, tyrosine (receptor) Q9UM73 238 2p23.2-p23.1 human K1610-me 206219700 HYEDTILkSKNSMNQ phosphorylation carcinogenesis, induced; cell growth, induced; signaling pathway regulation 28370702 1 1 0 induces AKT phosphorylation and phosphorylation of itself on other sites, regulates the EML4-ALK pathway +RHO Rhodopsin GPCR, family 1; Membrane protein, integral; Membrane protein, multi-pass; Receptor, GPCR P02699 509933 cow T340-p 448681 ASTTVSKtETSQVAP molecular association, regulation; protein conformation SAG(INDUCES) 15041682 3 2 0 Computational and in vitro data. S343 may be a weaker interaction. +DNMT1 DNMT1 Amino Acid Metabolism - cysteine and methionine; Cell development/differentiation; EC 2.1.1.37; METHYLTRANSFERASE; Methyltransferase; Methyltransferase, DNA; Transcription regulation P26358 1786 19p13.2 human S878-p 27447600 QDYARFEsPPKTQPT BAH protein stabilization; molecular association, regulation; enzymatic activity, induced transcription, induced HDAC1(INDUCES); GATA1(INDUCES); HDAC2(INDUCES); Bcl-11A(INDUCES) DNA(INDUCES) 33227819 1 4 0 +DCK DCK EC 2.7.1.74; Kinase, other; Nucleotide Metabolism - purine; Nucleotide Metabolism - pyrimidine P27707 1633 4q13.3 human S11-p 460585 PPKRSCPsFSASSEG phosphorylation 20544527 4 29 6 regulates phosphorylation of S74 +GJA1 GJA1 Channel, misc.; Membrane protein, integral; Membrane protein, multi-pass; Motility/polarity/chemotaxis P17302 2697 6q22.31 human S325-p 449992 NRMGQAGsTISNSHA Connexin43 protein conformation 23828237 10 14 0 +SIK3 QSK EC 2.7.11.1; KINASE; Kinase, protein; Motility/polarity/chemotaxis; Protein kinase, CAMK; Protein kinase, Ser/Thr (non-receptor) Q9Y2K2 23387 11q23.3 human S551-p 468543 GPLGRRAsDGGANIQ molecular association, regulation transcription, induced 14-3-3 beta(INDUCES) 22588126; 26048985 7 48 120 +AR AR DNA-binding; Nuclear receptor; Transcription factor P10275 367 Xq12 human T851-p 5204777 ACKRKNPtSCSRRFY Hormone_recep activity, induced; protein stabilization; molecular association, regulation; ubiquitination; intracellular localization carcinogenesis, induced; cell growth, induced; transcription, induced Src(INDUCES); RNF6(INDUCES); AR(INDUCES) Other(INDUCES) 22584579; 35163481 2 0 1 induces binding to a "62SLQFLLDT68" co-activator peptide +MAPK14 P38A EC 2.7.11.24; KINASE; Kinase, protein; Protein kinase, CMGC; Protein kinase, Ser/Thr (non-receptor) Q16539 1432 6p21.31 human R70-me 1878212801 IHAKRTYrELRLLKH enzymatic activity, induced cell differentiation, induced; transcription, induced 31243342 1 0 0 MyoD-mediated myogenic differentiation and transcription +Arap3 ARAP3 GAP; GAP, ARF; Motility/polarity/chemotaxis Q8R5G7 106952 18|18 B3 mouse Y1404-p 454958 PVYEEPVyEEVGAFP cell motility, altered; cytoskeletal reorganization 15546919 3 1 3 +TUBA1A TUBA1A Cytoskeletal; Motility/polarity/chemotaxis Q71U36 7846 12q13.12 human K40-ac 460619 DGQMPSDkTIGGGDD Tubulin acetylation; protein stabilization; molecular association, regulation; intracellular localization; phosphorylation cell cycle regulation; carcinogenesis, induced; cell motility, induced; transcription, induced; cell motility, inhibited; signaling pathway regulation; cell adhesion, inhibited; DNA repair, induced; autophagy, induced; cell growth, induced; cell differentiation, induced; cell motility, altered; apoptosis, inhibited; cytoskeletal reorganization KIF5B(INDUCES); NFAT1(DISRUPTS); LRRK2(DISRUPTS) 12024216; 12606581; 17084703; 19185337; 19896110; 20308065; 20484055; 20978170; 21278340; 22193721; 22658602; 23580651; 24275654; 26382850; 26763233; 26870991; 27311481; 27311773; 27430620; 27454931; 27721410; 27836544; 28394342; 31919191; 32514048; 32788234; 32846968; 32885602; 32908309; 34503512; 35504282; 35884497 71 7 11 staining for trimethylation of H3K9 increased early in infection; acetylation of tubulin enables microtubules from this center to rotate the nucleus to maximizing virus replication; TMIGD1/moesin pathway may regulate tubulin acetylation, affecting cytoskeletal organization and cell motility; Runx2 silencing is accompanied by reduced microtubule stability +PPP1R3C PPP1R3C Motility/polarity/chemotaxis; Protein phosphatase, regulatory subunit Q9UQK1 5507 10q23.32 human S33-p 6423500 MRLCLAHsPPVKSFL protein degradation; ubiquitination; enzymatic activity, inhibited 19171932 1 7 1 +Pak1 PAK1 EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, STE; Protein kinase, Ser/Thr (non-receptor) P35465 29431 1q32 rat T84-p 450680 LPSDFEHtIHVGFDA PBD enzymatic activity, inhibited 14707132 1 0 0 prevents activation by Cdc42 +Oprk1 KOR-1 GPCR, family 1; Membrane protein, integral; Membrane protein, multi-pass; Receptor, GPCR P33534 18387 1 A1|1 1.89 cM mouse S356-p 52467200 KMRMERQsTNRVRNT receptor internalization, induced; intracellular localization 26635353; 28893975 2 1 0 +FLOT1 FLOT1 Adaptor/scaffold O75955 10211 6p21.33 human Y56-p 35494100 NVKSEKVyTRHGVPI Band_7 molecular association, regulation SDHB(INDUCES) 24983503 1 0 0 decreased ROS productioned compared to Y56F and Y149F mutants +VIM Vimentin Cytoskeletal; Motility/polarity/chemotaxis P08670 7431 10p13 human S8-p 471087 MSTRSVSsSSYRRMF Filament_head cell motility, altered 19291697 3 3 1 +Ulk1 ULK1 Autophagy; EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, Other; Protein kinase, Ser/Thr (non-receptor) O70405 22241 5|5 F mouse S224-p 10428802 GKAPFQAsSPQDLRL Pkinase cell cycle regulation; autophagy, induced; cell growth, induced 32516310 1 1 0 +MDM2 MDM2 EC 6.3.2.-; EC 6.3.2.19; Inhibitor; Ligase; NEDDYLATION LIGASE; Neddylation Ligase; Nucleolus; Oncoprotein; UBIQUITIN LIGASE; Ubiquitin conjugating system; Ubiquitin ligase Q00987 4193 12q15 human Y281-p 4251185 EVYQVTVyQAGESDT protein stabilization transcription, inhibited UBE2M(INDUCES) 25624478 2 1 0 stabilization of p53 levels, neddylated-P53, represses p53-mediated maspin gene expression +Unc5c UNC5C Membrane protein, integral; Receptor, misc. O08747 22253 3 H1|3 65.57 cM mouse Y568-p 12563302 QGRVYEMyVTVHRKE ZU5 molecular association, regulation PLCG1(INDUCES); SHP-2(INDUCES) 11533026 1 1 0 SHP-2 and UNC5C bind in vitro and in vivo +Cebpb C/EBP-beta DNA-binding; Motility/polarity/chemotaxis; Transcription factor P21272 24253 3q42 rat K134-sm 6140810 PPPPAALkAEPGFEP protein degradation 35002525 3 2 0 C/EBP-beta PARylation inhibits its SUMOylation at K174 +RHOT1 RHOT1 EC 3.6.5.-; G protein; G protein, monomeric; G protein, monomeric, Rho; Hydrolase; Membrane protein, integral; Mitochondrial Q8IXI2 55288 17q11.2 human K153-ub 22250894 ECSAKNLkNISELFY Ras protein degradation; intracellular localization autophagy, induced 34152608 2 2 0 induces mitophagy by recruiting Parkin to mitochondria +PDE4D PDE4D iso2 EC 3.1.4.53; Nucleotide Metabolism - purine; Phosphodiesterase Q08499-2 5144 5q11.2-q12.1 human S579-p 451090 YQSTIPQsPSPAPDD enzymatic activity, inhibited 10022832; 10828059; 16973330 7 3 0 +CTDP1 CTDP1 EC 3.1.3.16; Motility/polarity/chemotaxis; PHOSPHATASE; Protein phosphatase, Ser/Thr (non-receptor); Transcription initiation complex Q9Y5B0 9150 18q23 human T584-p 455468 EEEEEEDtDEDDHLI molecular association, regulation; enzymatic activity, induced transcription, altered GTF2F1(INDUCES) 15723518; 19215094 2 0 0 +EIF6 EIF6 Nucleolus; Translation; Translation initiation P56537 3692 20q11.22 human S175-p 17535703 EDQDELSsLLQVPLV eIF-6 intracellular localization 21084295 1 2 0 required for the nuclear export of eIF6 +MYB Myb DNA-binding; Oncoprotein; Transcription factor P10242 4602 6q23.3 human S11-p 448186 RPRHSIYsSDEDDED molecular association, regulation transcription, altered DNA(DISRUPTS) 7735324 5 1 1 +BUB3 BUB3 Cell cycle regulation O43684 9184 10q26.13 human Y207-p 463080 EGRVAVEyLDPSPEV molecular association, regulation; intracellular localization cell cycle regulation; carcinogenesis, induced; cell growth, induced; apoptosis, inhibited; cytoskeletal reorganization CASC5(INDUCES) 24316223 1 3 2 +DRD2 DRD2 GPCR, family 1; Membrane protein, integral; Membrane protein, multi-pass; Receptor, GPCR P14416 1813 11q23.2 human S354-p 467255 PNGKTRTsLKTMSRR 7tm_1 molecular association, regulation; intracellular localization; activity, inhibited FLNA(DISRUPTS) 10692483 2 0 0 inhibits D2 receptor clustering on the cell surface +CIITA CIITA DNA-binding; EC 2.7.11.1; KINASE; Protein kinase, Ser/Thr (non-receptor); Transcription, coactivator/corepressor P33076 4261 16p13.13 human K141-ac 458928 MPAEVGQkSQKRPFP intracellular localization transcription, induced 11046145 1 0 0 nuclear localization +AKT1 Akt1 EC 2.7.11.1; KINASE; Kinase, protein; Oncoprotein; Protein kinase, AGC; Protein kinase, Ser/Thr (non-receptor) P31749 207 14q32.33 human K64-ub 1872904200 VAQCQLMkTERPRPN PH phosphorylation apoptosis, inhibited 28412322 1 0 0 enhaces Akt phosphorylation +MARCKS MARCKS Actin-binding; Motility/polarity/chemotaxis P16527 396473 chicken S26-p 455959 PGEAVAAsPSKANGQ MARCKS molecular association, regulation; intracellular localization cell cycle regulation; cell motility, induced; cell differentiation, induced ACTA1(INDUCES) 19366616; 23470634; 23634231 5 50 8 +Gja4 GJA4 Cell adhesion; Membrane protein, integral; Membrane protein, multi-pass P28235 14612 4 D2.2|4 61.47 cM mouse S321-p 1867850301 QGGRKSPsRPNSSAS protein conformation cell cycle regulation; apoptosis, induced 30736283 1 0 0 +THBS1 THBS1 Inhibitor; Motility/polarity/chemotaxis P07996 7057 15q14 human K472-ub 52490405 PSPQMNGkPCEGEAR TSP_1 protein degradation 26676607 0 1 0 +Sik2 QIK EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, CAMK; Protein kinase, Ser/Thr (non-receptor) Q8CFH6 235344 9|9 A5.3 mouse S343-p 2150903 RLKSHRSsFPVEQRL enzymatic activity, inhibited transcription, induced 23241891 3 6 4 +ELK1 ELK1 DNA-binding; Transcription factor P19419 2002 Xp11.23 human T417-p 452139 ISVDGLStPVVLSPG apoptosis, induced 34572320 8 0 1 +MRE11 MRE11A Cell cycle regulation; DNA repair, damage; DNA-binding; Deoxyribonuclease P49959 4361 11q21 human R580-m2 62978406 GRGRRGGrGQNSASR DNA repair, altered 15741314 0 1 0 +CDCA5 CDCA5 Cell cycle regulation Q96FF9 113130 11q13.1 human S181-p 20727382 AEDLSGVsPVVCSKL Sororin molecular association, regulation; activity, inhibited cell cycle regulation SCC-112(DISRUPTS); H2A.1(DISRUPTS); SMC3(DISRUPTS) 21878504; 23901111 2 7 0 +ADD1 ADD1 Cytoskeletal; Motility/polarity/chemotaxis P35611 118 4p16.3 human T724-p 5246050 KKKKKFRtPSFLKKS activity, induced; molecular association, regulation carcinogenesis, induced; cell motility, induced; transcription, induced; cytoskeletal reorganization ACTN1(DISRUPTS) 31548578 1 15 15 Increase lamellapodia formation and cell invasion +Stxbp1 STXBP1 Vesicle P61765 25558 3p11 rat S306-p 448743 VSQEVTRsLKDFSSS Sec1 exocytosis, altered 16997485 3 0 0 regulates protein secretion by increasing vesicle pools replenishment after stimulation +SLK SLK EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, STE; Protein kinase, Ser/Thr (non-receptor) Q9H2G2 9748 10q24.33-q25.1 human S347-p 466943 SSDLSIAsSEEDKLS enzymatic activity, inhibited 16837460 1 34 2 site is critical for v-src dependent modulation of SLK kinase activity +CDCA7 CDCA7 Cell cycle regulation Q9BWT1 83879 2q31.1 human T163-p 4774845 SRRPRRRtFPGVASR molecular association, regulation; intracellular localization 14-3-3 beta(INDUCES); Myc(DISRUPTS) 23166294 1 5 8 14-3-3 competes with MYC for binding to CDCA7 ; localization to cytoplasm after binding of 14-3-3 +MAF MAF Cell development/differentiation; DNA-binding; Oncoprotein; Transcription factor; Tumor suppressor O75444 4094 16q23.2 human Y131-p 25673103 LQGGFDGyARGAQQL activity, induced; molecular association, regulation transcription, induced DNA(INDUCES) 22798672 2 0 0 Interacts with IL-4 promoter and transactivates IL-4 +Ctnna1 CTNNA1 Actin-binding; Motility/polarity/chemotaxis P26231 12385 18 B1|18 18.89 cM mouse T654-p 467709 DFDVRSRtSVQTEDD Vinculin intracellular localization CDH1(DISRUPTS) 25970250 1 27 8 +MPIG6B G6B Immunoglobulin superfamily; Membrane protein, integral; Receptor, misc. O95866 80739 6p21.33 human S226-p 1983255 LSRPRRLsTADPADA G6B molecular association, regulation SH2D1B(NOT_REPORTED); Arg(NOT_REPORTED) 23322602 0 2 0 +HMGA2 HMGA2 DNA-binding; Oncoprotein P52926 8091 12q14.3 human K26-ac 474713 PAAPAPQkRGRGRPR AT_hook protein stabilization; molecular association, regulation DNA(INDUCES) 32313942 1 0 27 +TRPM4 TRPM4 Membrane protein, integral; Membrane protein, multi-pass Q8TD43 54795 19q13.33 human S1152-p 12559512 SERLKRTsQKVDLAL activity, induced 15590641 1 0 0 +TERF1 TRF1 DNA-binding P54274 7013 8q21.11 human T358-p 12115364 KKESRRAtESRIPVS protein stabilization; molecular association, regulation; phosphorylation carcinogenesis, induced; chromatin organization, altered; cell growth, induced; transcription, inhibited DNA(INDUCES) 33690611 1 0 1 binds telomeric DNA, inhibits CHK phosphorylation +CCR7 CCR7 GPCR, family 1; Membrane protein, integral; Membrane protein, multi-pass; Motility/polarity/chemotaxis; Receptor, GPCR P32248 1236 17q21.2 human S377-p 455292 AETTTTFsP______ phosphorylation 15054093 1 0 0 ERK1/2 phosphorylation +NABP2 OBFC2B Cell cycle regulation; DNA repair, damage Q9BQ15 79035 12q13.3 human S134-p 25302960 NDSNPSAsQPTTGPS DNA repair, induced 28448822 1 1 1 +TTK TTK Cancer Testis Antigen (CTA); EC 2.7.12.1; KINASE; Kinase, protein; Protein kinase, Other; Protein kinase, dual-specificity (non-receptor) P33981 7272 6q14.1 human K86-ub 12109968 LSDALLNkLIGRYSQ protein degradation cell cycle regulation 34586601 1 5 2 +Amot AMOT Q8VHG2 27494 X|X F2 mouse S176-p 28699604 QGHVRSLsERLMQMS protein stabilization; molecular association, regulation; intracellular localization signaling pathway regulation ACTB(DISRUPTS); LATS2(INDUCES) 23791731; 28947533 8 0 0 diffused cytoplasmic distribution of Amot vs colocalization of Amot and F-actin; Hippo pathway activation +Neurog1 neurogenin 1 Cell development/differentiation; DNA-binding; Transcription factor P70595 29410 17p14 rat S208-p 7590802 SPLSDPSsPSASEDF transcription, induced; cell growth, altered 19365559 1 0 0 +MDM2 MDM2 EC 6.3.2.-; EC 6.3.2.19; Inhibitor; Ligase; NEDDYLATION LIGASE; Neddylation Ligase; Nucleolus; Oncoprotein; UBIQUITIN LIGASE; Ubiquitin conjugating system; Ubiquitin ligase Q00987 4193 12q15 human T218-p 450150 SSSESTGtPSNPDLD molecular association, regulation; intracellular localization ARF1(INDUCES) 25915850 4 0 0 Arf-dependent nucleolus localization +MAP3K15 MAP3K15 EC 2.7.11.25; KINASE; Kinase, protein; Protein kinase, STE; Protein kinase, Ser/Thr (non-receptor) Q6ZN16 389840 Xp22.12 human T808-p 904653402 GVNPCTEtFTGTLQY Pkinase molecular association, regulation PPP6C(INDUCES) 29539411 1 0 0 required for interaction +AFDN Afadin iso3 Cell adhesion; Motility/polarity/chemotaxis; Oncoprotein P55196-3 4301 6q27 human S1718-p 481813 KERQRLFsQGQDVSN signaling pathway regulation 30670780 2 47 300 PI3K/Akt signaling +DHPS DHPS Cell cycle regulation; EC 2.5.1.46; Transferase P49366 1725 19p13.13 human S233-p 1870426002 KNHIPVFsPALTDGS DS enzymatic activity, induced cell growth, induced 32989218 1 0 0 +USF1 USF1 DNA-binding; Transcription factor P22415 7391 1q23.3 human T153-p 463815 EALLGQAtPPGTGQF activity, induced; acetylation transcription, induced; transcription, inhibited 11532965; 16622840; 19389701; 21873430 4 1 0 +FOXA1 FOXA1 DNA-binding; Transcription factor P55317 3169 14q21.1 human Y429-p 60189900 QALQYSPyGSTLPAS HNF_C transcription, induced 27883218 1 0 0 +Xbp1 XBP1 DNA-binding; Transcription factor O35426 22433 11 A1|11 3.61 cM mouse S61-p 21688102 RQRLTHLsPEEKALR bZIP_1 intracellular localization apoptosis, induced; transcription, induced 21892182; 28717189; 34030589 4 7 0 +KAT2B PCAF ACETYLTRANSFERASE; Acetyltransferase; EC 2.3.1.48; Nuclear receptor co-regulator Q92831 8850 3p24.3 human K442-ac 458988 HVLEEAKkPRVMGDI enzymatic activity, induced 12888487 1 0 0 in vitro +Synj1 SYNJ1 Carbohydrate Metabolism - inositol phosphate; EC 3.1.3.36; Motility/polarity/chemotaxis; Phosphatase, lipid; Vesicle Q62910 85238 11q11 rat S1160-p 450679 REMEAPKsPGTARKD molecular association, regulation endophilin A1(DISRUPTS) 14704270 1 2 2 +RORA RORA DNA-binding; Nuclear receptor P35398 6095 15q22.2 human K441-ub 1883509401 SWLQEKVkIEKLQQK Hormone_recep protein degradation 36114756 1 0 0 PRMT5 is involved in RORa degradation by regulating ITCH binding R37A (mutant) +MIF MIF Amino Acid Metabolism - phenylalanine; Amino Acid Metabolism - tyrosine; Apoptosis; Cell development/differentiation; Cytokine; EC 5.3.2.1; EC 5.3.3.12; Isomerase P14174 4282 22q11.23 human S112-gl 48990005 ANVGWNNsTFA____ MIF molecular association, regulation carcinogenesis, inhibited; cell growth, inhibited; cell motility, inhibited EGFR(INDUCES) 26280537 1 1 0 binds to EGFR and blocks EGF binding to EGFR +MSH6 MSH6 DNA-binding P52701 2956 2p16.3 human K1126-m1 58123204 EEEQENGkAYCVLVT molecular association, regulation L3MBTL iso4(INDUCES) 23583077 0 1 0 +CREM CREM DNA-binding; Transcription factor Q03060 1390 10p11.21 human S271-p 450065 QGVVMAAsPGSLHSP ubiquitination; intracellular localization transcription, induced 21767532 3 14 2 +MAP2K6 MKK6 iso2 EC 2.7.12.2; KINASE; Kinase, protein; Protein kinase, STE; Protein kinase, dual-specificity (non-receptor) P52564-2 5608 17q24.3 human S151-p 448194 ISGYLVDsVAKTIDA Pkinase enzymatic activity, induced 8621675 13 20 65 +PSEN1 PSEN1 Cell surface; EC 3.4.23.-; Membrane protein, integral; Membrane protein, multi-pass; Mitochondrial; Protease P49768 5663 14q24.2 human S319-p 3397301 NSKYNAEsTERESQD Presenilin protein stabilization; enzymatic activity, induced 18667537 1 0 0 +TP53 p53 Activator; DNA-binding; Motility/polarity/chemotaxis; Nuclear receptor co-regulator; Transcription factor; Tumor suppressor P04637 7157 17p13.1 human S106-p 27300200 SQKTYQGsYGFRLGF P53 protein stabilization MDM2(DISRUPTS) 23201157 1 1 0 +H2BC3 H2B DNA-binding P33778 3018 6p22.2 human K24-ac 482539 AITKAQKkDGKKRKR Histone molecular association, regulation polybromo 1(INDUCES) 20368734 1 1 7 varying site specificity binding for each bromodomain 1-6 +CARM1 CARM1 EC 2.1.1.125; METHYLTRANSFERASE; Methyltransferase; Methyltransferase, protein arginine; Nuclear receptor co-regulator Q86X55 10498 19p13.2 human S447-p 25268707 LIANKRQsYDISIVA molecular association, regulation transcription, induced; signaling pathway regulation ER-alpha(INDUCES) 20360387 1 0 0 +UIMC1 RAP80 Nuclear receptor co-regulator; Transcription, coactivator/corepressor Q96RL1 51720 5q35.2 human S46-p 470701 AFIVISDsDGEEPKE molecular association, regulation SUMO2(INDUCES) 26719330 1 28 3 +TSC2 TSC2 Cell cycle regulation; GAP; GAP, misc.; Nuclear receptor co-regulator; Tumor suppressor P49815 7249 16p13.3 human S981-p 454014 AFRCRSIsVSEHVVR molecular association, regulation; intracellular localization; activity, inhibited carcinogenesis, inhibited; cell growth, inhibited; autophagy, inhibited; signaling pathway regulation 14-3-3 zeta(INDUCES); 14-3-3 epsilon(INDUCES) 16636147; 27451907; 32308763 7 30 14 cell survival induced; TSC2/RHEB/mTOR signaling pathway +POU6F1 POU6F1 DNA-binding; Transcription factor Q14863 5463 12q13.13 human S197-p 1869383200 KLDITPKsAQKLKPV Pou molecular association, regulation cell differentiation, induced; cytoskeletal reorganization DNA(DISRUPTS) 31665313 1 1 0 role in skeletal muscle differentiation and skeletal myogenesis +PHLPP1 PHLPP EC 3.1.3.16; PHOSPHATASE; Protein phosphatase, Ser/Thr (non-receptor); Tumor suppressor O60346 23239 18q21.33 human S412-p 30988996 PLPQTASsPQPQQKA cell cycle regulation 33397691 1 2 0 +TCF3 E2A iso2 Cell development/differentiation; DNA-binding; Oncoprotein; Transcription factor P15923-2 6929 19p13.3 human S359-p 465682 SPSTPVGsPQGLAGT molecular association, regulation transcription, induced NEUROD1(INDUCES) 12810726 2 7 31 +AGTR1 AT1 GPCR, family 1; Membrane protein, integral; Membrane protein, multi-pass; Receptor, GPCR P30556 185 3q24 human S338-p 452092 STKMSTLsYRPSDNV activity, induced; molecular association, regulation; intracellular localization; receptor internalization, altered ARRB1(INDUCES); ARRB2(INDUCES) 11579203; 15177932 5 0 0 +LZTS2 LZTS2 Nuclear export Q9BRK4 84445 10q24.31 human S220-p 1871717501 PSGTLSDsGRNSLSS protein degradation; molecular association, regulation; ubiquitination; phosphorylation carcinogenesis, induced; cell motility, induced; cell growth, induced; signaling pathway regulation BTRC(INDUCES) 33420362 1 0 0 induces phosphorylation of downstream targets thus inducing the PI3K/AKT signaling pathway +MAML1 MAML1 Transcription, coactivator/corepressor Q92585 9794 5q35.3 human K188-ac 11319879 LGLDSLNkKRLADSS molecular association, regulation Notch 1(INDUCES) 28625977 1 2 0 +PHB2 BAP37 Mitochondrial; Nuclear receptor co-regulator; Transcription, coactivator/corepressor Q99623 11331 12p13.31 human S39-p 1868188300 VAYGVREsVFTVEGG molecular association, regulation autophagy, induced LC3A(INDUCES) 33820826 2 0 0 induces mitophagy +CTNNB1 CTNNB1 Actin-binding; Cell adhesion; Motility/polarity/chemotaxis; Nuclear receptor co-regulator; Oncoprotein; Transcription factor P35222 1499 3p22.1 human T393-p 449562 RNLSDAAtKQEGMEG activity, induced; molecular association, regulation; protein stabilization; phosphorylation transcription, induced; transcription, altered axin 1(DISRUPTS) 12700239; 19565571 2 0 0 +NFATC3 NFAT4 DNA-binding; Transcription factor Q12968 4775 16q22.1 human S163-p 448857 SYRESSLsPSPASSI intracellular localization transcription, inhibited 9374467 1 3 0 +Rarg RARG iso2 DNA-binding; Nuclear receptor P18911-2 19411 15 F3|15 57.4 cM mouse S68-p 455544 EMVPSSPsPPPPPRV activity, induced; protein degradation transcription, altered 12032135 3 0 0 +SPEN SHARP Nuclear receptor co-regulator; RNA-binding; Spliceosome; Transcription factor Q96T58 23013 1p36.21-p36.13 human T3568-p 455622 EGVARRMtVETDYCL SPOC transcription, altered 15824732 1 0 0 +NCOA3 SRC-3 ACETYLTRANSFERASE; Acetyltransferase; EC 2.3.1.48; Motility/polarity/chemotaxis; Nuclear receptor co-regulator; Transcription, coactivator/corepressor Q9Y6Q9 8202 20q13.12 human S543-p 454108 SLLSTLSsPGPKLDN NCOA_u2 molecular association, regulation carcinogenesis, induced; cell growth, induced; transcription, induced ER-alpha(DISRUPTS) 15383283; 16760465; 23850489; 33542078 7 0 0 +Atg13 ATG13 Autophagy; Vesicle Q91YI1 51897 2|2 E1 mouse S224-p 53377101 DRPYPSSsPMHPCNY autophagy, inhibited 26801615 2 2 0 +CORO7 coronin 7 Vesicle P57737 79585 16p13.3 human Y758-p 2853108 GDTRVFLyELLPESP phosphorylation signaling pathway regulation 33162394 2 0 0 inhibits phosphorylation of YAP7 and hence the Hippo signaling pathway +Pak1 PAK1 EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, STE; Protein kinase, Ser/Thr (non-receptor) P35465 29431 1q32 rat S149-p 448171 YMSFTDKsAEDYNSS enzymatic activity, induced 11278486 1 2 31 +YAP1 YAP1 Oncoprotein; Transcription, coactivator/corepressor P46937 10413 11q22.1 human S403-p 3190675 ESTDSGLsMSSYSVP protein degradation; ubiquitination carcinogenesis, inhibited; cell motility, inhibited 36828627 2 3 0 +RBM17 RBM17 RNA splicing; RNA-binding; Spliceosome Q96I25 84991 10p15.1 human S62-p 27936100 IDLKRGGsSDDRQIV molecular association, regulation; phosphorylation cell motility, induced RNA(DISRUPTS) 23519612 1 2 0 induced cell invasion, enhanced Cortactin phosphorylation at ERK-dependent sites +Cry1 CRY1 DNA-binding; Lyase; Transcription, coactivator/corepressor P97784 12952 10 C1|10 41.63 cM mouse K107-ub 27766300 YDSEPFGkERDAAIK DNA_photolyase protein stabilization; molecular association, regulation 23452856 1 2 0 +CREBBP CBP ACETYLTRANSFERASE; Acetyltransferase; DNA-binding; EC 2.3.1.48; Motility/polarity/chemotaxis; Nuclear receptor co-regulator; Transcription, coactivator/corepressor Q92793 1387 16p13.3 human R768-me 475952 GMAISPSrMPQPPNM molecular association, regulation; acetylation; enzymatic activity, induced transcription, induced; signaling pathway regulation RAC3(INDUCES); ER-alpha(INDUCES) DNA(INDUCES) 12374746; 21632823 2 0 0 steroid hormone signaling, GRIP1 and steroid hormone-induced transcription; induces CBP autoacetylation +Lck Lck EC 2.7.10.2; KINASE; Kinase, protein; Oncoprotein; Protein kinase, TK; Protein kinase, tyrosine (non-receptor) P06240 16818 4 D2.2|4 63.26 cM mouse S59-p 447820 EGSLPPAsPLQDNLV enzymatic activity, inhibited cell growth, inhibited 25535246; 8077654 10 2 7 +KAT5 Tip60 ACETYLTRANSFERASE; Acetyltransferase; EC 2.3.1.48; Nuclear receptor co-regulator; Nucleolus Q92993 10524 11q13.1 human K282-ac 1872267901 CLQRHLTkCDLRHPP zf-MYST protein degradation apoptosis, inhibited 16001085 1 0 0 Tip60 targeting by HIV Tat +MITF MITF DNA-binding; Oncoprotein; Transcription factor O75030 4286 3p13 human K372-ub 964527258 QREQQRAkELENRQK protein degradation; molecular association, regulation autophagy, induced SQSTM1(INDUCES) 35092699 1 1 0 +AFG3L2 AFG3L2 Cell development/differentiation; Chaperone; EC 3.4.24.-; Membrane protein, integral; Membrane protein, multi-pass; Mitochondrial; Protease Q9Y4W6 10939 18p11.21 human Y179-p 462232 WKDFVNNyLSKGVVD FtsH_ext protein processing 24767997 1 0 18 prevents SPG7 processing, regulates mitochondrial bioenergetics and mROS production +STMN1 STMN1 Cytoskeletal P16949 3925 1p36.11 human S38-p 448556 SVPEFPLsPPKKKDL Stathmin protein degradation; protein stabilization; molecular association, regulation; activity, inhibited; phosphorylation cell cycle regulation; carcinogenesis, inhibited; cell growth, inhibited; apoptosis, induced; cell motility, induced; cell motility, inhibited; signaling pathway regulation; cytoskeletal reorganization; cell growth, altered TUBA1A(DISRUPTS); TUBB(DISRUPTS); GRP78(INDUCES) 11015208; 19033656; 19162178; 20110360; 23230143; 27130664; 31546234; 7775478; 8144611; 9271428; 9712920 49 114 166 Stathmin hyperphosphorylation leads to microtubule stability. +CTLA4 CTLA-4 Immunoglobulin superfamily; Membrane protein, integral P16410 1493 2q33.2 human Y218-p 450898 CEKQFQPyFIPIN__ molecular association, regulation; intracellular localization SHP-1(INDUCES) 10604992; 11970985 3 0 0 +PRKRA PACT Activator; RNA processing; RNA-binding O75569 8575 2q31.2 human S246-p 470037 TDYIQLLsEIAKEQG molecular association, regulation; enzymatic activity, induced apoptosis, altered; apoptosis, induced PACT(INDUCES) 16982605; 21526770; 22473766 4 0 1 PKR enzymatic activity induced; activates PKR +MAP3K5 ASK1 EC 2.7.11.25; KINASE; Kinase, protein; Protein kinase, STE; Protein kinase, Ser/Thr (non-receptor) Q99683 4217 6q23.3 human S1033-p 451423 EDHSAPPsPEEKDSG enzymatic activity, inhibited; phosphorylation apoptosis, altered 15094778; 35438255 2 32 0 +CSF2RB CSF2RB Membrane protein, integral; Receptor, cytokine P32927 1439 22q12.3 human Y593-p 450103 SFDFNGPyLGPPHSR activity, induced; molecular association, regulation; receptor internalization, altered; phosphorylation apoptosis, altered; cell motility, altered; transcription, altered; cell growth, altered GRB2(INDUCES); Fos(NOT_REPORTED); SHC1(INDUCES); SHP-2(INDUCES) 10329850; 10672044; 10704825; 10760518; 17638849; 8631792; 8752899; 9209304; 9257712 12 0 0 Y593 may be required for phosphorylation of Shc.; Y593 phosphorylation is essential for Shc phosphorylation and activation of Shc and the c-fos promoter. ; Y593-p is important for activation of the Fos promoter. ; Phosphorylation of Y628, Y711, or Y766 is necessary and sufficient for STAT activation by IL-5. +GBF1 GBF1 GEF; GEF, ARF Q92538 8729 10q24.32 human Y877-p 1875829500 QDILEDMyHAIKNEE Sec7 molecular association, regulation; intracellular localization; protein conformation ARF1(INDUCES) 34870592 1 1 0 induces GALNT relocation +Gsk3b GSK3B EC 2.7.11.1; EC 2.7.11.26; KINASE; Kinase, protein; Protein kinase, CMGC; Protein kinase, Ser/Thr (non-receptor) Q9WV60 56637 16|16 B3 mouse S9-p 449111 SGRPRTTsFAESCKP activity, induced; molecular association, regulation; protein stabilization; intracellular localization; enzymatic activity, inhibited; activity, inhibited; phosphorylation cell cycle regulation; carcinogenesis, induced; cell motility, induced; cell adhesion, induced; signaling pathway regulation; cell growth, induced; transcription, inhibited; cell growth, altered; cell differentiation, inhibited; cell growth, inhibited; transcription, induced; transcription, altered; neural plasticity; cell differentiation, induced; apoptosis, inhibited; cytoskeletal reorganization; autophagy, inhibited 14-3-3 zeta(INDUCES) 11035810; 12095987; 14522959; 15791206; 15845746; 16055726; 17178402; 18851840; 19106302; 20111716; 20332342; 20592205; 20724593; 21821713; 21998135; 22172670; 24614172; 28562582; 31672472; 32209671; 33804171; 33829789; 33863923; 34140410; 34203583; 34453977; 34638997; 34642308; 34710087; 34778891; 34794022; 34930892; 34949833; 35145222; 35358489; 35950912; 36027949; 36065437; 36090685; 36103829; 36209826; 36293516; 37033243; 37370133; 37392853 570 46 227 regulatws the NFAT signaling pathway; inhibits HIF1A degradation +HVCN1 HVCN1 iso4 Channel, cation; Membrane protein, integral; Membrane protein, multi-pass Q96D96-4 84329 12q24.11 human T9-p 472529 SKFLRHFtVVGDDYH activity, induced; receptor internalization, induced carcinogenesis, induced 25425665 2 0 3 HVCN1s channel currents turn on more rapidly and current amplitude is increased than HVCN1-L channels Receptor-internalization more in HVCN1-L than HVCN1s +Ncor1 N-CoR1 Nuclear receptor co-regulator; Transcription, coactivator/corepressor Q60974 20185 11|11 B2 mouse S2348-p 2888301 NKSNSRKsKSPIPGQ molecular association, regulation 14-3-3 beta(INDUCES) 17630505 1 5 1 +KDM1A LSD1 DEMETHYLASE; Demethylase; EC 1.-.-.-; Nuclear receptor co-regulator; Oxidoreductase; Transcription factor O60341 23028 1p36.12 human S126-p 3175618 EYREMDEsLANLSED cell cycle regulation 28344766 1 12 0 S126 phosphorylation promotes LSD1 release from chromatin during mitosis +ECHS1 ECHS1 Amino Acid Metabolism - lysine degradation; Amino Acid Metabolism - tryptophan; Amino Acid Metabolism - valine, leucine and isoleucine degradation; Carbohydrate Metabolism - butanoate; Carbohydrate Metabolism - propanoate; EC 4.2.1.17; Lipid Metabolism - fatty acid; Lipid Metabolism - fatty acid elongation in mitochondria; Lyase; Mitochondrial; Other Amino Acids Metabolism - beta-alanine; Secondary Metabolites Metabolism - limonene and pinene degradation P30084 1892 10q26.3 human K101-ac 467120 FAAGADIkEMQNLSF ECH_1 protein degradation; ubiquitination; intracellular localization; enzymatic activity, inhibited carcinogenesis, induced; signaling pathway regulation 28878358 1 7 16 activates mTOR signaling +TYK2 Tyk2 EC 2.7.10.2; KINASE; Kinase, protein; Protein kinase, TK; Protein kinase, tyrosine (non-receptor) P29597 7297 19p13.2 human Y1055-p 447503 VPEGHEYyRVREDGD PK_Tyr_Ser-Thr enzymatic activity, induced signaling pathway regulation 31341059; 8702790 8 2 5 +BUB3 BUB3 Cell cycle regulation O43684 9184 10q26.13 human S211-p 452546 AVEYLDPsPEVQKKK molecular association, regulation carcinogenesis, inhibited; apoptosis, induced; transcription, inhibited DMAP1(INDUCES) DNA(INDUCES) 30553276 1 14 0 Blocks mitotic arrest +NPM/ALK NPM-ALK KINASE; Kinase, protein; Protein kinase, TK; Protein kinase, tyrosine (receptor) AAA58698 human Y342-p 27275106 RDIYRASyYRKGGCA PK_Tyr_Ser-Thr enzymatic activity, induced 19887368 3 2 3 +Myb Myb DNA-binding; Oncoprotein; Transcription factor P06876 17863 10 A3|10 9.75 cM mouse K523-sm 486352 PPLLKKIkQEVESPT Cmyb_C sumoylation; protein stabilization; intracellular localization; protein conformation transcription, inhibited 11779867; 16162816; 17077080 4 1 0 slight increase in conjugation of two and three molecules of SUMO-2 with S528A phospho-mutant under stress +TFAM TFAM DNA-binding; Transcription regulation Q00059 7019 10q21.1 human K154-ac 1876567506 KELTLLGkPKRPRSA HMG_box_2 transcription, induced 35278431 0 1 0 +DDX21 DDX21 EC 3.6.4.13; Helicase; Nucleolus; RNA processing; RNA-binding Q9NR30 9188 10q22.1 human K18-ac 461852 LESDTAMkKGETLRK enzymatic activity, inhibited transcription, inhibited 28790157 1 0 28 Inhibits DDX21 helicase activity, impairs genomic stability, R-loop mediated stalling of RNA polymerase +ADRB2 ADRB2 GPCR, family 1; Membrane protein, integral; Membrane protein, multi-pass; Receptor, GPCR P07550 154 5q32 human T68-p 4047201 FERLQTVtNYFITSL 7tm_1 activity, induced 17925438 1 0 0 G-protein activation +Lat LAT Adaptor/scaffold; Membrane protein, integral O54957 16797 7|7 F3 mouse Y175-p 448004 SVESCEDyVNVPESE LAT intracellular localization; phosphorylation cell adhesion, altered Fyn(INDUCES) 15470052; 17579183 24 1 17 Localization of recruited PLCG2 to the membrane/cytoskeleton; Fyn may be involved in LAT phosphorylation.; regulates exocytosis and cytokine secretion +GIT1 GIT1 GAP; GAP, ARF; Motility/polarity/chemotaxis Q9Y2X7 28964 17q11.2 human S700-p 465672 PALEPVRsSLRLLNA GIT1_C molecular association, regulation cytoskeletal reorganization PXN iso2(INDUCES) 16797488 1 2 0 +RPAP3 RPAP3 Unknown function Q9H6T3 79657 12q13.11 human S116-p 472436 DSTHESLsQESESEE molecular association, regulation 35129352 1 14 8 inhibits binding to ribosomal proteins and biogenesis factors associated with small (40S) and large (60S) subunits of the ribosome +Dlg2 PSD-93 Adaptor/scaffold Q91XM9 23859 7 E1|7 51.07 cM mouse Y348-p 450885 TRPPEPVySTVNKLC molecular association, regulation CSK(INDUCES) 13129934 1 3 147 +ADARB1 RED1 EC 3.5.4.37; Hydrolase; Nucleolus; RNA-binding P78563 104 21q22.3 human T553-p 31884906 LQGERLLtMSCSDKI A_deamin enzymatic activity, inhibited 31095429 1 1 0 +GHR GH receptor Membrane protein, integral; Receptor, cytokine P10912 2690 5p13.1-p12 human Y595-p 450480 SEMPVPDyTSIHIVQ GHBP molecular association, regulation SOCS2(INDUCES) 25505247 3 1 0 The following proteins have been pulled-down by GHR_Y595 beads: CRL5-SOCS2 E3 ligase complex (SOCS2, EloB, EloC, Cul5, Rbx2) , and Cul1, FBXO31, Rbx1, Skp1, CISH, CSK and NEDD8 +Vav1 VAV1 GEF; GEF, Rac/Rho; Motility/polarity/chemotaxis; Oncoprotein P27870 22324 17 D|17 29.76 cM mouse Y541-p 3744041 MLLRGTFyQGYRCYR C1_1 activity, induced 24736456 1 1 3 based on a lower activity of Y->F mutant in Jurkat cells stimulated by anti-CD3 antibody +Ola1 OLA1 EC 3.6.3.-; Hydrolase; Nucleolus Q9CZ30 67059 2|2 C3 mouse T325-p 1880539200 AWTIRKGtKAPQAAG protein stabilization; molecular association, regulation; ubiquitination; enzymatic activity, altered transcription, induced DNA(INDUCES) 36481055 1 1 0 inhibits ubiquitination +Stat1 STAT1 DNA-binding; Transcription factor P42225 20846 1 C1.1|1 26.81 cM mouse Y701-p 447754 DDPKRTGyIKTELIS protein degradation; sumoylation; molecular association, regulation; ubiquitination; intracellular localization; activity, inhibited; phosphorylation carcinogenesis, inhibited; apoptosis, induced; autophagy, inhibited; transcription, induced; transcription, inhibited; cell growth, altered DNA(INDUCES) 11226159; 12640464; 17255531; 17346795; 18574148; 18941537; 21636857; 31896593; 32209571; 33125792; 33504618; 33574087; 33941660; 34303919; 34753772 204 7 64 +CSNK1A1 CK1A EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, CK1; Protein kinase, Ser/Thr (non-receptor) P48729 1452 5q32 human K62-ub 12112130 PQLLYESkLYKILQG Pkinase protein degradation 26909574 1 7 8 +Dzip1 DZIP1 C2H2-type zinc finger protein Q8BMD2 66573 14|14 E4 mouse S210-p 62403301 QRRHTEDsHLEYNTK molecular association, regulation PCM-1(DISRUPTS) 27979967 1 1 0 dissociation of the BBSome from PCM1 and the removal of the BBSome and Dzip1 from the CS at the G2 phase +HSP90AA1 HSP90A Chaperone; Heat shock protein P07900 3320 14q32.31 human K294-ac 486377 QEELNKTkPIWTRNP HSP90 activity, induced; molecular association, regulation cell growth, induced HSP70(DISRUPTS); HER2(DISRUPTS); HOPX(DISRUPTS); FKBP4(DISRUPTS); AR(DISRUPTS); AHSA1(DISRUPTS); CHIP(DISRUPTS); Src(DISRUPTS); CDC37(DISRUPTS); Chk1(DISRUPTS) 17218278 4 3 0 +TP53BP1 53BP1 DNA repair, damage; Transcription, coactivator/corepressor Q12888 7158 15q15.3 human R1403-me 2344818 RGRGRRGrPPSRTTG molecular association, regulation DNA(INDUCES) 16294045 2 0 0 +Npas4 NPAS4 DNA-binding Q8BGD7 225872 19|19 A mouse T423-p 1871095704 LSKDLVCtPPYTPHQ molecular association, regulation neural plasticity; transcription, induced CBP(INDUCES) 31801086 1 1 0 +TP73 p73 DNA-binding; Transcription factor; Tumor suppressor O15350 7161 1p36.32 human T27-p 2063601 SSLEPDStYFDLPQS molecular association, regulation; activity, inhibited transcription, induced; transcription, inhibited DNA(DISRUPTS) 18418051; 25379016 3 0 0 induced-spheroid formation, clonogenicty and side population of CSC genes +PI4KB PIK4CB iso2 Carbohydrate Metabolism - inositol phosphate; EC 2.7.1.67; Kinase, lipid; Motility/polarity/chemotaxis Q9UBF8-2 5298 1q21.3 human T504-p 457624 EQLAHTPtAFKRDPE intracellular localization 16606619 1 2 0 T504-phosphorylated PIK4CB localizes in the nucleus +TSC1 TSC1 Motility/polarity/chemotaxis; Tumor suppressor Q92574 7248 9q34.13 human S579-p 911089200 CQTSLETsIFTPSPC Hamartin intracellular localization cell cycle regulation; cell growth, altered 29559472 1 0 0 decreased lysosomal localization of the TSC complex +GFAP GFAP Cytoskeletal P14136 2670 17q21.31 human S13-p 449619 ITSAARRsYVSSGEM Filament_head molecular association, regulation; protein stabilization; protein processing; intracellular localization fascin(INDUCES) 12177195; 19170683; 31682229 11 5 0 GFAP aggregation induced; promotes GFAP cleavage by caspase-6 +RUVBL1 RUVBL1 EC 3.6.4.12; Helicase; Motility/polarity/chemotaxis Q9Y265 8607 3q21.3 human T239-p 41608704 KEIIQDVtLHDLDVA TIP49 cell cycle regulation 26201077 1 0 0 +PCBP2 hnRNP E2 RNA splicing; RNA-binding Q15366 5094 12q13.13 human T213-p 482919 SASFPHTtPSMCLNP protein stabilization; molecular association, regulation cell differentiation, inhibited; translation, inhibited RNA(INDUCES) 17475908 1 0 0 +PIGR PIGR Immunoglobulin superfamily; Membrane protein, integral; Receptor, misc. P01832 100328593 rabbit S682-p 451431 RRNVDRVsIGSYRTD intracellular localization 8343953 1 8 2 S682 phosphorylation is required for transcytosis of poly-Ig receptor in the absence digA. +GLS glutaminase Amino Acid Metabolism - alanine, aspartate and glutamate; Amino Acid Metabolism - arginine and proline; EC 3.5.1.2; Energy Metabolism - nitrogen; Hydrolase; Mitochondrial; Other Amino Acids Metabolism - D-Glutamine and D-glutamate O94925 2744 2q32.2 human K311-sc 33359373 YVHRYVGkEPSGLRF Glutaminase protein conformation; enzymatic activity, induced carcinogenesis, induced; cell growth, induced GLS2(INDUCES) 33991485 1 2 0 succinylation results in conformational changes, enhanced oligomerization, apoptosis induced by antioxidative stress +ADD1 ADD1 Cytoskeletal; Motility/polarity/chemotaxis P35611 118 4p16.3 human S12-p 481591 SRAAVVTsPPPTTAP molecular association, regulation cytoskeletal reorganization MYO10(INDUCES) 24379415 2 49 0 association with mitotic spindles +Chpt1 CHPT1 EC 2.7.8.2; Lipid Metabolism - ether lipid; Lipid Metabolism - glycerophospholipid; Membrane protein, integral; Membrane protein, multi-pass; Transferase Q8C025 212862 10|10 C1 mouse K307-ub 12718512 MFGCVFAkVAQKLVI TM protein degradation; enzymatic activity, inhibited 20018880 1 0 0 +CALCA CALCA Secreted; Secreted, signal peptide P01258 796 11p15.2 human T105-p 25285789 QDFNKFHtFPQTAIG Calc_CGRP_IAPP protein conformation 33220304 0 1 1 Delay peptide fibril formation +Per2 PER2 Nuclear receptor co-regulator; Nucleolus; Transcription factor Q9Z301 63840 9q36 rat S662-p 470017 GKAESVVsLTSQCSY intracellular localization 35227001 3 1 1 +LATS1 LATS1 EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, AGC; Protein kinase, Ser/Thr (non-receptor); Tumor suppressor O95835 9113 6q25.1 human T1079-p 457595 EHAFYEFtFRRFFDD activity, induced; protein degradation; intracellular localization; enzymatic activity, inhibited; phosphorylation; enzymatic activity, induced cell cycle regulation; carcinogenesis, inhibited; apoptosis, induced; cell growth, inhibited; cell motility, inhibited; transcription, inhibited; signaling pathway regulation 15688006; 24362629; 27847303; 30800215; 31239271; 31792377; 33630828; 34465890; 35307353; 35804016; 37319316 34 1 0 +MORC2 MORC2 DNA-binding Q9Y6X9 22880 22q12.2 human T733-p 3217920 PIKLSPAtPSRKRSV protein degradation; molecular association, regulation cell cycle regulation; carcinogenesis, inhibited; autophagy, induced; cell growth, inhibited; apoptosis, induced LAMP2(INDUCES); HSC70(INDUCES) 36967563 1 10 8 +TAOK1 TAO1 EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, STE; Protein kinase, Ser/Thr (non-receptor) Q7L7X3 57551 17q11.2 human S554-p 3627515 ELNSFLEsQKREYKL cell cycle regulation 17396146 1 0 1 +ULK1 ULK1 Autophagy; EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, Other; Protein kinase, Ser/Thr (non-receptor) O75385 8408 12q24.33 human S317-p 35495300 SHLASPPsLGEMQQL autophagy, induced; cell growth, inhibited; transcription, altered 34604061; 34759263; 34820368 20 1 0 +BIRC5 Survivin Apoptosis O15392 332 17q25.3 human K90-ub 40439805 GCAFLSVkKQFEELT protein degradation 25778398 1 1 0 impairs mitochondrial function +Cgas cGAS EC 2.7.7.86 Q8C6L5 214763 9|9 E1 mouse S420-p 1869388601 QELDAFCsYHVKTAI Mab-21_C molecular association, regulation; protein conformation; enzymatic activity, induced transcription, induced DNA(INDUCES) 32474700 2 0 0 enhances GTP binding +RARG RARG DNA-binding; Nuclear receptor P13631 5916 12q13.13 human S371-p 62884000 YARRRRPsQPYMFPR Hormone_recep activity, induced 31740618 2 0 0 +Rps6kb2 P70S6KB EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, AGC; Protein kinase, Ser/Thr (non-receptor); Translation Q9Z1M4 58988 19|19 A mouse S410-p 455989 SFQPKLRsPRRLNSS phosphorylation 17980619 2 0 3 +H4c2 H4 DNA-binding P62804 295277 rat K12-ac 459013 KGGKGLGkGGAKRHR transcription, induced 19909801 93 25 531 +ARHGEF2 ARHGEF2 GEF; GEF, Rac/Rho; Motility/polarity/chemotaxis Q92974 9181 1q22 human Y198-p 1869121005 IDEAEVIySELMSDF intracellular localization; protein conformation; enzymatic activity, induced cell motility, induced; cytoskeletal reorganization 31420453 1 0 0 induces Rho activation +Atf4 ATF-4 DNA-binding; Transcription factor Q06507 11911 15 E1|15 37.85 cM mouse S218-p 448436 DTPSDNDsGICMSPE protein degradation neural plasticity 33198401 4 0 0 +TSC1 TSC1 Motility/polarity/chemotaxis; Tumor suppressor Q92574 7248 9q34.13 human S511-p 3208191 DSPFYRDsLPGSQRK Hamartin protein degradation; molecular association, regulation; ubiquitination; phosphorylation carcinogenesis, induced; cell growth, induced; signaling pathway regulation TSC2(DISRUPTS) 17693255 4 6 11 induces S6K1 phosphorylation, activates mTOR pathway +Kif3a KIF3A Microtubule-binding; Motor P28741 16568 11 B1.3|11 31.97 cM mouse T694-p 31906433 KRSAKPEtVIDSLLQ activity, induced; molecular association, regulation CDH2(INDUCES) 26335646 1 4 0 enhances N-cadhedrin transport and affects synapse formation +Hist3h2ba H2B DNA-binding D3ZNZ9 303175 10q22 rat S14-p 449904 TPAPKKGsKKAITKA Histone chromatin organization, altered; apoptosis, induced 20057502 10 1 0 +Pde3b PDE3B EC 3.1.4.17; Membrane protein, integral; Membrane protein, multi-pass; Nucleotide Metabolism - purine; Phosphodiesterase Q63085 29516 1q34 rat S279-p 447699 VIRPRRRsSCVSLGE molecular association, regulation 14-3-3 beta(INDUCES) 12453887 4 7 78 +PPP2CA PPP2CA EC 3.1.3.16; Motility/polarity/chemotaxis; PHOSPHATASE; Protein phosphatase, Ser/Thr (non-receptor) P67776 pig Y307-p 448571 VTRRTPDyFL_____ signaling pathway regulation 23799098 73 1 0 simvastatin-induced signaling for the closure of K-ATP channel +CDC25C CDC25C EC 3.1.3.48; Motility/polarity/chemotaxis; PHOSPHATASE; Protein phosphatase, dual-specificity P30307 995 5q31.2 human S191-p 450979 EDQAEEIsDELMEFS M-inducer_phosp intracellular localization 14968113 1 1 1 +Ctnnd1 CTNND1 Actin-binding; Adaptor/scaffold; Cell adhesion; G protein regulator, misc.; Motility/polarity/chemotaxis P30999 12388 2 D|2 49.45 cM mouse K622-ac 3689228 AASCFGAkKGKDEWF cytoskeletal reorganization 16916647 0 1 24 +ITGB2 ITGB2 Cell adhesion; Cell surface; Membrane protein, integral; Motility/polarity/chemotaxis; Receptor, misc. P05107 3689 21q22.3 human T760-p 450185 LFKSATTtVMNPKFA Integrin_b_cyt molecular association, regulation kindlin-3(INDUCES) 23823319 3 0 0 +Gabrb3 GABRB3 Channel, chloride; Channel, ligand-gated; Membrane protein, integral; Membrane protein, multi-pass; Transporter; Transporter, ion channel NP_058761 24922 1q22 rat S384-p 20503435 EMNEVAGsVGDTRNS Neur_chan_memb receptor internalization, induced signaling pathway regulation 30820888 2 1 0 Ca2+/CaMKII-mediated signaling pathway +AP2M1 AP2M1 Adaptor/scaffold; Vesicle Q96CW1 1173 3q27.1 human T156-p 448782 SQITSQVtGQIGWRR activity, induced; molecular association, regulation; intracellular localization endocytosis, induced ATP1A1(NOT_REPORTED) 11877457; 16498080; 33137362; 34315807 9 33 29 +RACK1 RACK1 Adaptor/scaffold; G protein; G protein, heterotrimeric; G protein, heterotrimeric beta; Motility/polarity/chemotaxis; Nuclear receptor co-regulator P63244 10399 5q35.3 human K271-m2 63354300 KIIVDELkQEVISTS molecular association, regulation; ubiquitination HIF1A(DISRUPTS) 28279976 1 1 0 suppresses HIF-1alpha ubiquitination and oxygen-independent degradation, leading to accumulation of HIF-1a +Cad CAD Amino Acid Metabolism - alanine, aspartate and glutamate; EC 2.1.3.2; EC 3.5.2.3; EC 6.3.5.5; Hydrolase; KINASE; Ligase; Nucleotide Metabolism - pyrimidine; Transferase B2RQC6 69719 5|5 B1 mouse S1859-p 451247 PPRIHRAsDPGLPAE carcinogenesis, induced; cell motility, induced; cell growth, induced; apoptosis, inhibited 36122209 11 88 86 +STIM1 STIM1 Calcium-binding; Endoplasmic reticulum; Membrane protein, integral Q13586 6786 11p15.4 human S621-p 3635048 SRSHSPSsPDPDTPS molecular association, regulation; intracellular localization; activity, inhibited; protein conformation; phosphorylation cell motility, induced EB1(DISRUPTS); ORAI1(INDUCES) 25447552; 25562429; 28935720; 33023909 8 11 1 GPER activation to inhibit SOCE; accelerates cell migration in wound-healing assays; NFAT translocation to the nucleus, multimerization; phosphorylation of STIM1 at S621may increase SOCE activity +Usp9x USP9X DEUBIQUITINASE; EC 3.4.19.12; Protease; Ubiquitin conjugating system; Ubiquitin-specific protease P70398 22284 X A1.1|X 7.95 cM mouse S1600-p 467832 SDVDDDMsGDEKQDN UCH enzymatic activity, induced 26936881 1 46 2 +Ubtf UBF DNA-binding; Nucleolus; Transcription factor P25976 21429 11|11 D mouse S484-p 450180 DRGKLPEsPKRAEEI HMG_box_5 transcription, induced 10202152 3 34 60 +RAF1 RAF1 EC 2.7.11.1; KINASE; Kinase, protein; Oncoprotein; Protein kinase, Ser/Thr (non-receptor); Protein kinase, TKL P04049 5894 3p25.2 human S642-p 455309 NACTLTTsPRLPVF_ molecular association, regulation; intracellular localization; enzymatic activity, inhibited HRas(DISRUPTS) 15664191 1 27 23 +HMGN1 HMGN1 DNA-binding; Nuclear receptor co-regulator P05114 3150 21q22.2 human K18-ac 458844 GAAKEEPkRRSARLS HMG14_17 molecular association, regulation DNA(DISRUPTS) 10753971 1 0 6 +AP2B1 AP2B1 Vesicle P63010 163 17q12 human S258-p 178605774 ANSAVVLsAVKVLMK Adaptin_N intracellular localization 31492751 1 1 0 suppresses its nuclear accumulation +CFLAR CFLAR Apoptosis O15519 8837 2q33.1 human S273-p 7590800 LLRDTFTsLGYEVQK Peptidase_C14 protein degradation 19339247 1 0 0 +BLM BLM DNA repair, damage; DNA replication; EC 3.6.4.12; Helicase P54132 641 15q26.1 human K259-ub 28132102 AQESDSLkTHLEDER BLM_N molecular association, regulation; intracellular localization DNA repair, inhibited RAP80(INDUCES) 23708797 1 0 0 +TRPV3 TRPV3 Channel, cation; Membrane protein, integral; Membrane protein, multi-pass Q8NET8 162514 17p13.2 human T264-p 334535805 EGFYFGEtPLALAAC Ank activity, induced 29084846 1 0 0 modulation of TRPV3 channel activity +GPSM3 GPSM3 G protein regulator, misc. Q9Y4H4 63940 6p21.32 human S35-p 4717965 STTRPWRsAPPSPPP protein stabilization; molecular association, regulation; intracellular localization 14-3-3 beta(INDUCES) 22843681 1 24 7 +MAPT Tau iso8 ACETYLTRANSFERASE; Acetyltransferase; Cytoskeletal P10636-8 4137 17q21.31 human S293-p 449327 NVQSKCGsKDNIKHV Tubulin-binding molecular association, regulation 21204788 5 1 0 in vitro microtubule binding +Cebpb C/EBP-beta DNA-binding; Motility/polarity/chemotaxis; Transcription factor P28033 12608 2 H3|2 87.58 cM mouse S181-gl 7789201 SGSLSTSsSSSPPGT molecular association, regulation; phosphorylation cell differentiation, inhibited; transcription, inhibited DNA(DISRUPTS) 19478079 1 1 0 prevents phosphorylation of T179, S184, T188 +SOS1 SOS1 Adaptor/scaffold; GEF; GEF, Ras; Motility/polarity/chemotaxis Q07889 6654 2p22.1 human S1178-p 451315 IMSKHLDsPPAIPPR molecular association, regulation GRB2(DISRUPTS) 8816480 1 18 0 +DDX5 DDX5 EC 3.6.4.13; Helicase; Nuclear receptor co-regulator; Nucleolus; RNA splicing; RNA-binding; Spliceosome P17844 1655 17q23.3 human T564-p 27156800 SFRTGNPtGTYQNGY P68HR apoptosis, induced 23110695 1 0 0 +MCM7 MCM7 DNA replication; EC 3.6.4.12; Motility/polarity/chemotaxis P33993 4176 7q22.1 human S365-p 10027300 LVGGVDQsPRGMKIR MCM cell cycle regulation 23720738 2 6 1 +Traf2 TRAF2 Autophagy; EC 6.3.2.-; Ligase; UBIQUITIN LIGASE; Ubiquitin conjugating system; Ubiquitin ligase P39429 22030 2|2 A3 mouse K21-ub 486265 LLQPGFSkTLLGTRL protein degradation 11909853 1 0 0 +TFAM TFAM DNA-binding; Transcription regulation Q00059 7019 10q21.1 human K76-ac 1883522700 KAQNPDAkTTELIRR molecular association, regulation TOMM70A(DISRUPTS) 36474281 1 0 0 mitochondrial biogenesis impairment +MTA2 MTA2 DEACETYLASE; DNA-binding; Deacetylase; Motility/polarity/chemotaxis; Nuclear receptor co-regulator; Transcription factor O94776 9219 11q12.3 human K32-ub 12363625 RRIEELNkTANGNVE BAH protein degradation 26676607 0 8 5 +Crtc1 TORC1 Transcription factor Q157S1 684527 16p14 rat S215-p 60885604 KAGSRPKsCEVPGIN TORC_M transcription, induced 27903866 1 0 0 neuroprotection against 6-OHDA cytotoxicity +IRF3 IRF3 DNA-binding; Transcription factor Q14653 3661 19q13.33 human S175-p 14567912 PQPLRSPsLDNPTPF molecular association, regulation transcription, inhibited IRF7(INDUCES) 24275658 3 9 0 Formation of IRF3:IRF7 dimers +EYA1 EYA1 Apoptosis; Cell development/differentiation; DNA repair, damage; EC 3.1.3.16; EC 3.1.3.48; Motility/polarity/chemotaxis; PHOSPHATASE; Protein phosphatase, tyrosine (non-receptor) Q99502 2138 8q13.3 human S299-p 41156500 SDRLRRGsDGKSRGR sumoylation cell motility, induced; transcription, induced 24954506 1 0 0 reduces sumoylation +RIC8A RIC8A GEF; GEF, misc. Q9NPQ8 60626 11p15.5 human S502-p 3213318 VIQPMGMsPRGHLTS Ric8 ubiquitination; protein conformation cell cycle regulation 24466196 2 37 2 +HEXIM1 HEXIM1 Motility/polarity/chemotaxis; Transcription factor O94992 10614 17q21.31 human Y271-p 2835700 QRDFSETyERYHTES HEXIM molecular association, regulation; intracellular localization transcription, inhibited; transcription, altered CCNT1(DISRUPTS); CDK9(DISRUPTS); CDK9(INDUCES); LARP7(DISRUPTS) 15965233; 25900325 3 1 0 nuclear localization, inhibits proviral gene expression, inhibition of 7SK snRNP complex aassembly +TP53BP1 53BP1 DNA repair, damage; Transcription, coactivator/corepressor Q12888 7158 15q15.3 human S1219-p 481849 DDTESLHsQGEEEFD cell cycle regulation 18996087 3 19 42 +Scarb1 SCARB1 Membrane protein, integral; Membrane protein, multi-pass; Receptor, misc. P97943 25073 12q15 rat K500-ub 12395920 SLMSPAAkGTVLQEA protein degradation 28669731 1 4 1 +LAMP2 LAMP2 Membrane protein, integral P13473 3920 Xq24 human T213-p 386186606 PSPTTTPtPKEKPEA protein degradation; intracellular localization; protein conformation carcinogenesis, induced; autophagy, induced; cell growth, induced 29176575; 33685990 2 0 0 +FOXC2 FOXC2 Apoptosis; Cell development/differentiation; DNA-binding; Transcription factor Q99958 2303 16q24.1 human T247-p 7322584 SPRSAAStPAGSPDG molecular association, regulation transcription, altered DNA(INDUCES) 23878394 1 1 0 implicated in vascular remodeling in vivo +Arrb2 ARRB2 Adaptor/scaffold Q91YI4 216869 11 B3|11 42.99 cM mouse K107-ub 6140805 RLQDRLLkKLGQHAH Arrestin_N molecular association, regulation mAChR M2(INDUCES); mAChR m1(INDUCES) 19055777 1 0 0 +CEBPB C/EBP-beta DNA-binding; Motility/polarity/chemotaxis; Transcription factor P17676 1051 20q13.13 human S325-p 11180067 EQLSRELsTLRNLFK transcription, induced 1314426 1 0 0 +TOP2A TOP2A EC 5.99.1.3; Isomerase P11388 7153 17q21.2 human T1244-p 3180474 KKIKNENtEGSPQED sumoylation cell cycle regulation 30871006 1 13 0 influences sumoylation of K1240 +Ctnnb1 CTNNB1 Actin-binding; Cell adhesion; Motility/polarity/chemotaxis; Nuclear receptor co-regulator; Oncoprotein; Transcription factor Q02248 12387 9 F4|9 72.19 cM mouse T41-p 447583 GIHSGATtTAPSLSG protein degradation; ubiquitination cell differentiation, inhibited; carcinogenesis, inhibited; cell growth, inhibited; cell motility, inhibited 34642308; 35013220; 9233789 102 3 0 +PTGER4 PTGER4 GPCR, family 1; Membrane protein, integral; Membrane protein, multi-pass; Receptor, GPCR P35408 5734 5p13.1 human S377-p 450696 SSAMSGHsRSFISRE molecular association, regulation ARRB1(INDUCES) 14709160 1 0 0 +H3C1 H3 DNA-binding P68431 8350 6p22.2 human K79-m3 1458614 REIAQDFkTDLRFQS Histone cell cycle regulation; carcinogenesis, induced; cell growth, induced; chromatin organization, altered; cytoskeletal reorganization; transcription, inhibited 19805358; 22190683; 23227340 17 4 0 indicator of mitosis and tumor cell proliferation; regulates chromosome seggregation and cell senescence; regulates nucleosome dynamics +ETS1 Ets-1 DNA-binding; Motility/polarity/chemotaxis; Oncoprotein; Transcription factor P13474 396235 chicken S285-p 449318 QRVPSYDsFDSEDYP Ets1_N_flank activity, inhibited 7961750 6 10 56 The in vitro interaction of Ets-1 with a high-affinity Ets binding site was assayed with EMSA. +Cttn Cortactin Actin-binding; Cytoskeletal; Motility/polarity/chemotaxis Q60598 13043 7|7 F5 mouse Y475-p 3973973 TTEAPGHyQAEDDTY molecular association, regulation cell motility, induced FAK(DISRUPTS) 22078467 1 1 1 +N Nucleocapsid Protein P59595 1489678 SARSCoV1 S203-p 1868174954 RNSTPGSsRGNSPAR CoV_nucleocap molecular association, regulation Nucleocapsid Protein(INDUCES) 23717688 3 3 0 di-domain self-association +Mapk9 JNK2 EC 2.7.11.24; KINASE; Kinase, protein; Protein kinase, CMGC; Protein kinase, Ser/Thr (non-receptor) Q9WTU6 26420 11|11 B1.2-B1.3 mouse T183-p 447649 ACTNFMMtPYVVTRY Pkinase enzymatic activity, induced apoptosis, induced; cell motility, induced; transcription, inhibited 16061178; 18032450; 26306048 72 21 435 GTS sequence motif within the activation loop offers a higher phosphorylation efficiency and therefore functional activation of JNK1 over JNK2.; Fyn and thapsigargin-induced cell death; transcription leading to gene expression, epithelial cell migration and eyelid closure. +SMAD3 SMAD3 DNA-binding; Nuclear receptor co-regulator; Transcription factor P84022 4088 15q22.33 human K117-ac 1881518200 EFAFNMKkDEVCVNP carcinogenesis, induced; transcription, induced 34392614 1 0 0 upregulates immune response-related cytokines, recruits myeloid-derived suppressor cells and promotion of metastasis +NIN NIN Cytoskeletal; Microtubule-binding Q8N4C6 51199 14q22.1 human K1641-sm 12004428 EQEKFNLkEELERCK intracellular localization 16154161 1 0 0 +SCFD1 SCFD1 Vesicle Q8WVM8 23256 14q12 human S303-p 3207654 ESSGVENsPAGARPK Sec1 molecular association, regulation autophagy, induced PCAF(DISRUPTS) 35465820 1 67 17 SCFD1 phosphorylation promotes its deacetylation +AGAP2 CENTG1 iso2 GAP; GAP, ARF; Motility/polarity/chemotaxis; Tumor suppressor Q99490-2 116986 12q14.1 human Y774-p 467225 QGRTALFyARQAGSQ Ank_2 molecular association, regulation; protein stabilization apoptosis, altered; cell growth, induced AMPKA2(INDUCES) 16841086; 26001218 2 0 0 +ABL1 Abl iso2 EC 2.7.10.2; KINASE; Kinase, protein; Oncoprotein; Protein kinase, TK; Protein kinase, tyrosine (non-receptor) P00519-2 25 9q34.12 human Y488-p 450295 EGCPEKVyELMRACW PK_Tyr_Ser-Thr molecular association, regulation; phosphorylation apoptosis, inhibited MIG-6(DISRUPTS) 22975324 2 4 287 inhibits Mig6-dependent proapoptotic activation, inhibits Abl phosphorylation +AGAP2 CENTG1 iso2 GAP; GAP, ARF; Motility/polarity/chemotaxis; Tumor suppressor Q99490-2 116986 12q14.1 human S629-p 4719772 THLSRVRsLDLDDWP ArfGap molecular association, regulation; enzymatic activity, induced cell growth, altered NFkB-p105(INDUCES) 19176382 1 3 0 enhances proliferation , foci formation, and tumor progression in prostate cancer cells +Brsk2 BRSK2 EC 2.7.11.1; EC 2.7.11.26; KINASE; Kinase, protein; Protein kinase, CAMK; Protein kinase, Ser/Thr (non-receptor) Q69Z98 75770 7|7 F5 mouse T432-p 17551645 PLSSPRVtPHPSPRG protein stabilization; enzymatic activity, inhibited; phosphorylation 23790753 1 3 0 inhibits axon branching (activated in BRSK2 18A mutant) +PTTG1 Securin Cell cycle regulation; Oncoprotein O95997 9232 5q33.3 human K48-ub 12718508 VSTPRFGkTFDAPPA Securin protein degradation 20080579 1 3 0 +Dpysl3 CRMP-4 Hydrolase Q62952 25418 18p11-q11 rat T509-p 454328 PVFDLTTtPKGGTPA molecular association, regulation TUBB3(DISRUPTS); SLC25A5(DISRUPTS); CRMP-2(DISRUPTS); CRMP-1(DISRUPTS); PIN1(INDUCES); SLC25A4(DISRUPTS); DYRK1A(DISRUPTS) 18220421 3 50 16 +SOX9 SOX9 DNA-binding; Transcription factor P48436 6662 17q24.3 human S181-p 456981 YQPRRRKsVKNGQAE activity, induced; molecular association, regulation; intracellular localization carcinogenesis, induced; cell motility, induced; cell differentiation, induced; transcription, induced; cytoskeletal reorganization; signaling pathway regulation KPNB1(INDUCES) 10805756; 15889150; 19470758; 20039424; 21818404; 32277958 12 2 0 ADCK5-SOX9-PTTG1 pathway; increased migration of cancer cells +SMARCAL1 SMARCAL1 EC 3.6.1.-; EC 3.6.4.-; Helicase Q9NZC9 50485 2q35 human S123-p 29606711 QMALTGIsPPLAQSP protein degradation 30996091 1 9 0 +ADRB2 ADRB2 GPCR, family 1; Membrane protein, integral; Membrane protein, multi-pass; Receptor, GPCR P07550 154 5q32 human Y132-p 449831 CVIAVDRyFAITSPF 7tm_1 activity, induced 17925438 3 0 0 G-protein activation +TTI1 TTI1 DNA repair, damage O43156 9675 20q11.23 human S828-p 9765114 DVADGNVsDFDNEEE protein degradation; molecular association, regulation; ubiquitination; enzymatic activity, induced; phosphorylation cell growth, induced; signaling pathway regulation; translation, inhibited DNAPK(INDUCES); ATM(INDUCES); FBXO9(INDUCES) 23263282; 24657168 2 12 1 mutation of site S828 increase phosphorylation of S6K1 and S6, mediates mTORC1 signaling +Xiap XIAP Apoptosis; EC 6.3.2.-; Ligase; UBIQUITIN LIGASE; Ubiquitin conjugating system; Ubiquitin ligase Q60989 11798 X|X A4 mouse S87-p 450336 VGRHRRIsPNCRFIN BIR protein stabilization cell growth, induced 25686839 10 0 0 +CREBBP CBP ACETYLTRANSFERASE; Acetyltransferase; DNA-binding; EC 2.3.1.48; Motility/polarity/chemotaxis; Nuclear receptor co-regulator; Transcription, coactivator/corepressor Q92793 1387 16p13.3 human Y1125-p 55377870 QLLGIPDyFDIVKNP Bromodomain cell differentiation, induced; signaling pathway regulation 30573679 1 2 0 regulates T-cell responses to infection, cytokine signaling pathway +NFE2L2 NRF2 DNA-binding; Transcription factor Q16236 4780 2q31.2 human S433-p 27461383 PEKELPVsPGHRKTP activity, induced; protein degradation; protein stabilization; molecular association, regulation; ubiquitination; intracellular localization transcription, induced; transcription, inhibited; signaling pathway regulation BTRC(INDUCES); FBW1B(INDUCES) 25909891; 31805502; 37627580 3 6 0 +Prkca PKCA EC 2.7.11.13; KINASE; Kinase, protein; Oncoprotein; Protein kinase, AGC; Protein kinase, Ser/Thr (non-receptor) P05696 24680 10q32.1 rat T497-p 448598 MDGVTTRtFCGTPDY Pkinase activity, induced 25477822 7 48 62 +KHDRBS1 KHDRBS1 RNA-binding Q07666 10657 1p35.2 human T328-p 1884166700 GAITRGAtVTRGVPP neural plasticity; RNA splicing, induced 37595869 1 0 0 +Pex14 PEX14 Adaptor/scaffold Q642G4 64460 5q36 rat S232-p 455420 NRRQFPPsPSAPKIP molecular association, regulation; intracellular localization; protein conformation PEX13(INDUCES); Catalase(DISRUPTS); PEX14(INDUCES) 32831175; 32854114 2 20 86 +FAS FAS Apoptosis; Cell surface; Membrane protein, integral; Receptor, cytokine P25445 355 10q23.31 human Y232-p 455221 SDVDLSKyITTIAGV Death molecular association, regulation; intracellular localization apoptosis, altered FAS(INDUCES); FADD(INDUCES); CASP8(INDUCES) 15660394; 17195092 2 0 0 Y232 or Y291 is required for Fas oligomerization +APOBEC3G APOBEC3G EC 3.5.4.-; Hydrolase; RNA processing; RNA-binding Q9HC16 60489 22q13.1 human T32-p 5044101 PILSRRNtVWLCYEV NAD2 activity, induced; molecular association, regulation; protein conformation 18836454 2 1 0 promotes APOBEC3G anti-viral activity, by inhibiting binding to HIV-1 viral infectivity factor and its subsequent ubiquitination and degradation +SCN5A SCN5A Channel, sodium; Membrane protein, integral; Membrane protein, multi-pass Q14524 6331 3p22.2 human K442-sm 1877008700 QEAMEMLkKEHEALT activity, induced 32075761 0 1 0 action potential prolongation +RARG RARG DNA-binding; Nuclear receptor P13631 5916 12q13.13 human S77-p 455543 SEEMVPSsPSPPPPP activity, induced transcription, induced 10748061 2 0 0 Transactivation of mRARb2 promoter +TRAIP TRAIP EC 6.3.2.-; Ligase; Nucleolus; UBIQUITIN LIGASE; Ubiquitin conjugating system; Ubiquitin ligase Q9BWF2 10293 3p21.31 human K462-sm 53529102 VPSLFQAkLDTFLWS protein stabilization; ubiquitination; intracellular localization 26820530 1 0 0 inhibits ubiquitination +OCLN occludin Cell adhesion; Membrane protein, integral; Membrane protein, multi-pass; Motility/polarity/chemotaxis Q16625 100506658 5q13.2 human S408-p 2906719 DYTTGGEsCDELEED molecular association, regulation; intracellular localization ZO1(DISRUPTS); occludin(DISRUPTS); occludin(INDUCES); Claudin-1(DISRUPTS); ZO2(DISRUPTS); Claudin-2(DISRUPTS) 21536752; 23758859 3 10 6 homo dimerization of occludin; . Phosphorylation affects occludin solubility and regulates assembly/disassembly of TJ proteins +EIF4EBP2 4E-BP2 Translation; Translation initiation Q13542 1979 10q22.1 human T46-p 449410 GGTLFSTtPGGTRII eIF_4EBP molecular association, regulation; protein conformation 4E-BP1(DISRUPTS) 25533957 4 25 70 +RBL2 Rb-like 2 Transcription, coactivator/corepressor; Tumor suppressor Q08999 5934 16q12.2 human S1035-p 449738 NMDAPPLsPYPFVRT molecular association, regulation cell cycle regulation; transcription, induced E2F4(DISRUPTS) 11157749; 12006580; 28289097 4 8 27 +H3C1 H3 DNA-binding P68431 8350 6p22.2 human K27-m3 1308913 LATKAARkSAPATGG Histone molecular association, regulation; ubiquitination; methylation; intracellular localization cell cycle regulation; carcinogenesis, induced; apoptosis, induced; cell motility, induced; cell adhesion, inhibited; signaling pathway regulation; cell growth, induced; transcription, inhibited; cell differentiation, inhibited; carcinogenesis, inhibited; cell growth, inhibited; transcription, induced; transcription, altered; DNA repair, induced; cell differentiation, induced; chromatin organization, altered; cytoskeletal reorganization H2AFV(INDUCES); CDYL2(INDUCES); RCOR1(DISRUPTS); CDYL(INDUCES); H2AZ(INDUCES) 15525528; 17589499; 18628788; 18931660; 19473514; 19477956; 19503595; 19523850; 19717977; 19883641; 20003410; 20033197; 20053926; 20152814; 20159609; 20385584; 20473313; 20543557; 20546607; 20547755; 20850016; 21059703; 21282660; 22897849; 22899583; 23238014; 23273982; 23328481; 23423141; 23772023; 23826380; 23893242; 24474760; 25605023; 25955299; 26263556; 27151441; 28751304; 28754676; 29371934; 31015297; 35184652; 35322029; 35694846; 36060800; 36165173; 36220978; 36461911 195 24 3 +ESR1 ER-alpha DNA-binding; Nuclear receptor; Transcription factor P03372 2099 6q25.1-q25.2 human K303-ub 1873286918 LMIKRSKkNSLALSL protein stabilization 29100376 1 0 0 +SMAD3 SMAD3 DNA-binding; Nuclear receptor co-regulator; Transcription factor P84022 4088 15q22.33 human S213-p 451180 NLSPNPMsPAHNNLD intracellular localization cell cycle regulation; signaling pathway regulation; transcription, inhibited; transcription, altered; cell growth, altered 10197981; 15241418; 20736297; 34360888 13 0 0 inhibits TGF-B signaling +PHB1 PHB Apoptosis; Cell cycle regulation; Chaperone; Mitochondrial; Motility/polarity/chemotaxis; Nuclear receptor co-regulator; Oncoprotein; Transcription, coactivator/corepressor P35232 5245 17q21.33 human Y259-p 6374000 SRSRNITyLPAGQSV O-GlcNAc glycosylation; protein stabilization; molecular association, regulation; intracellular localization; phosphorylation carcinogenesis, induced; cell motility, induced; transcription, induced; signaling pathway regulation NOTCH3(INDUCES); RAF1(INDUCES) 19238206; 22410782; 25575814; 32169072 5 2 0 induces phosphorylation at T258, NOTCH3 stabilization, PBX1 and ABCG2 transcription, induces NOTCH3/PBX1 and B-catenin/ABCG2 signaling pathway; induces ERK phosphorylation and modulates Ras phosphorylation; PIP3 induced migration/invasion, colonization/ metastasis +Sln sarcolipin Endoplasmic reticulum; Membrane protein, integral Q9CQD6 66402 9|9 A5.3 mouse T5-p 459214 ___MERStQELFINF Sarcolipin molecular association, regulation; enzymatic activity, altered SERCA2(INDUCES) 16461894; 25671318 6 0 0 sarcolipin T5A mutant results in abnormal Ca2+ handling and subsequent cardiac remodeling and dysfunction +RAF1 RAF1 EC 2.7.11.1; KINASE; Kinase, protein; Oncoprotein; Protein kinase, Ser/Thr (non-receptor); Protein kinase, TKL P05625 396245 chicken S339-p 447743 PRGQRDSsYYWEIEA intracellular localization apoptosis, inhibited 12843393 9 1 1 +NKX3-1 NKX3-1 DNA-binding; Transcription factor; Tumor suppressor Q99801 4824 8p21.2 human T93-p 464288 EAETLAEtEPERHLG protein stabilization 16581776 2 0 0 +CSNK1E CK1E EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, CK1; Protein kinase, Ser/Thr (non-receptor) P49674 1454 22q13.1 human T337-p 453419 PGPPTGAtANRLRSA enzymatic activity, inhibited 10542239; 12223474 2 0 0 some subset of these 8 sites +Tppp TPPP Cytoskeletal Q7TQD2 72948 13|13 C1 mouse T161-p 10273222 TKAVSSPtVSRLTDT p25-alpha cytoskeletal reorganization 25456499 1 3 0 spine development +Jak2 JAK2 EC 2.7.10.2; KINASE; Kinase, protein; Oncoprotein; Protein kinase, TK; Protein kinase, tyrosine (non-receptor) Q62120 16452 19 C1|19 23.73 cM mouse Y868-p 470141 GSVEMCRyDPLQDNT PK_Tyr_Ser-Thr enzymatic activity, induced 20304997 4 2 0 +Trpm8 TRPM8 Channel, cation; Membrane protein, integral; Membrane protein, multi-pass Q8R4D5 171382 1|1 D mouse S29-p 1874485104 RTLYSSVsRSTDVSY intracellular localization; activity, inhibited 34446569 1 1 0 +MALT1 MALT1 Adaptor/scaffold; Apoptosis; EC 3.4.22.-; Ligase; Nuclear export; Protease; UBIQUITIN LIGASE; Ubiquitin conjugating system Q9UDY8 10892 18q21.32 human K665-ub 2134703 LVSKDLPkHCLYTRL MALT1_Ig protein degradation; molecular association, regulation IKKA(INDUCES) 17948050 1 1 0 activation of NF-kB pathway and IL-2 induction +GRK1 GRK1 EC 2.7.11.14; KINASE; Kinase, protein; Protein kinase, AGC; Protein kinase, Ser/Thr (non-receptor) Q15835 6011 13q34 human S21-p 456353 AFIAARGsFDGSSSQ enzymatic activity, inhibited 15946941 4 1 1 reaction in vitro +Trpm7 ChaK1 Channel, cation; EC 2.7.11.1; KINASE; Kinase, protein; Membrane protein, integral; Membrane protein, multi-pass; Protein kinase, Ser/Thr (non-receptor); Protein kinase, atypical Q923J1 58800 2|2 F1 mouse S1511-p 455463 EDSPEVDsKAALLPD molecular association, regulation RHOA(INDUCES) 31844251 4 4 1 +BRCA1 BRCA1 EC 6.3.2.-; Nuclear receptor co-regulator; Transcription, coactivator/corepressor; Tumor suppressor; UBIQUITIN LIGASE; Ubiquitin conjugating system; Ubiquitin ligase P38398 672 17q21.31 human S1143-p 767900 PMGSSHAsQVCSETP intracellular localization 17531442 2 0 0 S1143 and S1280 phosphorylation contributes to BRCA1 recruitment to MMTS-induced foci. +Slc12a3 NCCT Membrane protein, integral; Membrane protein, multi-pass; Transporter; Transporter, SLC family P55018 54300 19p13-p12 rat T58-p 469617 LRTFGYNtIDVVPAY AA_permease_N activity, induced; ubiquitination; intracellular localization; receptor internalization, inhibited 20445498; 22415098; 22966159; 24668812 25 3 0 ubiquitination reduced +Myo3b MYO3B Actin-binding; EC 2.7.11.1; KINASE; Kinase, protein; Motor; Protein kinase, STE; Protein kinase, Ser/Thr (non-receptor) Q1EG27 329421 2|2 C2 mouse T918-p 36841908 TTNMKRQtMASYFRY Myosin_head enzymatic activity, induced 21895655 1 1 0 +Nfkbie IkB-epsilon DNA-binding; Inhibitor O54910 18037 17|17 B3 mouse S22-p 455581 QCDSGIEsLRSLRSL protein degradation 10497169 2 0 0 +Lpin1 LPIN1 EC 3.1.3.4; Phosphatase, lipid Q91ZP3 14245 12 A1.1|12 7.9 cM mouse K629-sm 10902805 LGLATRIkHESSSSD intracellular localization transcription, induced 19753306 1 0 0 +PSEN1 PSEN1 Cell surface; EC 3.4.23.-; Membrane protein, integral; Membrane protein, multi-pass; Mitochondrial; Protease P49768 5663 14q24.2 human S357-p 448563 PHRSTPEsRAAVQEL Presenilin molecular association, regulation; intracellular localization; protein conformation cell growth, altered CTNNB1(DISRUPTS); CDH2(DISRUPTS); CTNNB1(INDUCES) 11104755; 17360711; 17389597 3 1 10 GSK3beta activation downregulates PI3K/Akt signaling probably by reducing the interaction of PSEN1 with N-cadherin (CDH2)/ beta catenin (CTNNB1); reduced interaction was observed in the constitutively active GSK3beta (S9A) mutant; stabilizes beta catenin by reducing its ubiquitination and turn-over +GTF2I GTF2I DNA-binding; Transcription, coactivator/corepressor P78347 2969 7q11.23 human K221-sm 40724403 SCGPIKVkTEPTEDS molecular association, regulation carcinogenesis, induced; cell growth, induced HDAC3(DISRUPTS) 25869096 1 3 0 +TAOK2 TAO2 Apoptosis; EC 2.7.11.1; KINASE; Kinase, protein; Membrane protein, integral; Membrane protein, multi-pass; Protein kinase, STE; Protein kinase, Ser/Thr (non-receptor) Q9UL54 9344 16p11.2 human S181-p 7447419 SIMAPANsFVGTPYW Pkinase intracellular localization apoptosis, induced 17158878 1 2 1 +FNIP1 FNIP1 Q8TF40 96459 5q31.1 human S941-p 4734327 PRNESSDsALGDSES protein stabilization; molecular association, regulation signaling pathway regulation HSP90A(INDUCES) DNA(INDUCES) 30699359 1 2 0 +Ptk2 FAK EC 2.7.10.2; KINASE; Kinase, protein; Protein kinase, TK; Protein kinase, tyrosine (non-receptor) O35346 25614 7q34 rat K152-sm 2793927 NFFYQQVkSDYMLEI FERM_M phosphorylation 14500712 2 0 0 FAK autophosphorylation +MEF2C MEF2C DNA-binding; Transcription factor Q06413 4208 5q14.3 human K119-ac 12674412 ESEDKYRkINEDIDL HJURP_C molecular association, regulation cell differentiation, induced; transcription, induced MRF(INDUCES) DNA(INDUCES) 15831463 1 0 0 +RIT1 RIT1 G protein; G protein, monomeric; G protein, monomeric, Ras Q92963 6016 1q22 human S209-p 6424741 SVWKRLKsPFRKKKD molecular association, regulation; intracellular localization P311(DISRUPTS); Mad2(DISRUPTS) 34237269 1 4 1 regulates MAD2 dimerization by binding to MAD2 +DGCR8 DGCR8 Nucleolus; RNA processing; RNA-binding Q8WYQ5 54487 22q11.21 human S95-p 3208089 DPNCSGHsPRTARHA protein stabilization 24239349 1 31 2 +Glra1 GLRA1 Membrane protein, integral; Membrane protein, multi-pass; Transporter; Transporter, ion channel Q64018 14654 11 B1.3|11 33.12 cM mouse S408-p 1869137000 PPPAPSKsPEEMRKL molecular association, regulation; ubiquitination neural plasticity; endocytosis, induced EPS15(INDUCES) 31433808 2 1 0 +YAP1 YAP1 iso3 Oncoprotein; Transcription, coactivator/corepressor P46937-3 10413 11q22.1 human Y394-p 54390605 QQNRFPDyLEAIPGT activity, induced; molecular association, regulation; intracellular localization carcinogenesis, induced; cell growth, induced; transcription, induced TEAD1(INDUCES) 27013234 2 0 0 +PHLPP1 PHLPP EC 3.1.3.16; PHOSPHATASE; Protein phosphatase, Ser/Thr (non-receptor); Tumor suppressor O60346 23239 18q21.33 human S324-p 31871709 SPAPSDSsPGEPFVG cell cycle regulation 33397691 1 2 0 +CLASP2 CLASP2 Cytoskeletal; Motility/polarity/chemotaxis O75122 23122 3p22.3 human S1027-p 7320226 NPYNYSDsISPFNKS cell cycle regulation 23045552 1 5 2 +RAB11FIP1 RAB11FIP1 iso3 Vesicle Q6WKZ4-3 80223 8p11.23 human S234-p 4691719 QKTPLSQsMSVLPTS intracellular localization cytoskeletal reorganization 28396819 1 23 1 +SRSF10 SRSF10 RNA splicing; RNA-binding O75494 10772 1p36.11 human S133-p 453583 RRRSRSRsFDYNYRR molecular association, regulation hnRNP K(INDUCES); hnRNP F(INDUCES) 27851963 1 83 29 +LSM4 LSM4 RNA-binding; Spliceosome Q9Y4Z0 25804 19p13.11 human R90-m2 15381290 VVAKGRGrGGLQQQK molecular association, regulation SMN(INDUCES) 11720283 1 2 1 +JAK3 JAK3 EC 2.7.10.2; KINASE; Kinase, protein; Protein kinase, TK; Protein kinase, tyrosine (non-receptor) P52333 3718 19p13.11 human Y939-p 2197000 QICKGMEyLGSRRCV PK_Tyr_Ser-Thr molecular association, regulation; phosphorylation; enzymatic activity, induced STAT5A(INDUCES) 18250158 1 0 0 possible docking site for kinase substrates; required for STAT5A Y694 phosphorylation and its further transcriptional activation +SLC4A4 SLC4A4 Membrane protein, integral; Membrane protein, multi-pass; Transporter; Transporter, SLC family Q9Y6R1 8671 4q13.3 human T49-p 13194700 RRRHKRKtGHKEKKE activity, induced 12730338 2 0 0 S1026 phosphorylation alters stoichiometry shift, while T49 mediates increase in membrane conductance. +Pip4p1 TMEM55B EC 3.1.3.78; Hydrolase; Membrane protein, integral; Membrane protein, multi-pass Q3TWL2 219024 14|14 C1 mouse S76-p 4717517 GEDPPPYsPLTSPDS Tmemb_55A intracellular localization 31329883 1 1 0 +GRIN2B NMDAR2B Channel, calcium; Channel, ligand-gated; Membrane protein, integral; Membrane protein, multi-pass Q13224 2904 12p13.1 human S1303-p 450171 NKLRRQHsYDTFVDL NMDAR2_C activity, induced; receptor desensitization, inhibited; molecular association, regulation; phosphorylation CAMK2A(INDUCES); CAMK2A(DISRUPTS); DAPK1(INDUCES) 19453375; 21423658; 21768120; 25434386; 27998718; 28614711 48 14 31 +BLVRA BVR Cofactor and Vitamin Metabolism - porphyrin and chlorophyll; EC 1.3.1.24; KINASE; Kinase, protein; Oxidoreductase; Protein kinase, Ser/Thr (non-receptor) P53004 644 7p13 human Y198-p 455758 EERKEDQyMKMTVCL Biliv-reduc_cat enzymatic activity, induced 15870194 1 0 1 phosphorylation enhances BVR's antagonism of insulin-stimulated glucose uptake. +PTPRT PTPRT iso1 EC 3.1.3.48; Membrane protein, integral; Motility/polarity/chemotaxis; PHOSPHATASE; Receptor protein phosphatase, tyrosine O14522-1 11122 20q12-q13.11 human Y915-p 11315001 GYGFKEEyEALPEGQ molecular association, regulation; enzymatic activity, inhibited cell growth, altered PTPRT iso1(INDUCES); NLGN1(DISRUPTS) 19816407 1 0 0 attenuates synapse formation +RUNX3 AML2 DNA-binding; Transcription factor Q13761 864 1p36.11 human K171-ac 57676501 ATYHRAIkVTVDGPR Runt molecular association, regulation apoptosis, induced; transcription, induced; signaling pathway regulation BRD2(INDUCES) 24229708 1 0 0 induces p14-p53 pathway +DEF6 DEF6 GEF; GEF, Rac/Rho Q9H4E7 50619 6p21.31 human Y210-p 25687500 SMAIHEVyQELIQDV molecular association, regulation; intracellular localization; protein conformation DCP1A(INDUCES) 22829599 1 0 0 cytoplasmic granule formation +CCNB1 CCNB1 Activator; Cell cycle regulation P14635 891 5q13.2 human S147-p 448446 EDLCQAFsDVILAVN intracellular localization DNA(INDUCES) 11242082; 20117088; 22726437 7 1 0 The phosphorylation of S133 and S147 is necessary for the nuclear translocation of cyclin B1 during G2/M phase.; enhances nuclear import +Celf2 CELF2 iso3 RNA-binding Q792H5-3 29428 17q12.3 rat Y39-p 1870336227 LKELFEPyGAVYQIN RRM_1 molecular association, regulation RNA(INDUCES) 17855367 1 0 0 +IFNAR2 IFNAR2 Membrane protein, integral; Receptor, cytokine P48551 3455 21q22.11 human Y337-p 3063305 PRTSGGGyTMHGLTV activity, induced; molecular association, regulation; phosphorylation transcription, induced; signaling pathway regulation; transcription, altered STAT2(DISRUPTS) 11682488; 12105218; 20038197; 34813358 5 0 0 STAT phosphorylation and activation; lack of STAT1, 2, 3 phosphorylation in IFNAR2 Y337/512F mutant; induces STAT phosphorylation and signaling; IFN induced STAT activation and induced transcription +SCAMP3 SCAMP3 Membrane protein, integral; Membrane protein, multi-pass; Vesicle O14828 10067 1q22 human Y35-p 451850 QHRPSRQyATLDVYN molecular association, regulation EGFR(INDUCES) 33850265 1 12 206 +Nsf NSF Adaptor/scaffold; Autophagy; EC 3.6.4.6; Protease; Vesicle P46460 18195 11 E1|11 67.54 cM mouse S460-p 15794301 MNRHIKAsTKVEVDM AAA_lid_3 intracellular localization; enzymatic activity, induced 20962217 1 0 0 +PAPOLA PAP-alpha EC 2.7.7.19; RNA processing; RNA splicing; Transferase P51003 10914 14q32.2 human K663-sm 2586343 HKEESPKkTKTEEDE protein stabilization; intracellular localization; enzymatic activity, inhibited 18281463 1 0 0 +JAK1 JAK1 EC 2.7.10.2; KINASE; Kinase, protein; Protein kinase, TK; Protein kinase, tyrosine (non-receptor) P23458 3716 1p31.3 human S515-p 62372200 SLHGSDRsFPSLGDL molecular association, regulation 27919027 1 0 0 +SP1 SP1 C2H2-type zinc finger protein; DNA-binding; Transcription factor P08047 6667 12q13.13 human T640-gl 5262501 CGKVYGKtSHLRAHL zf-C2H2 transcription, induced 18513490 2 1 0 +XIAP XIAP Apoptosis; EC 6.3.2.-; Ligase; UBIQUITIN LIGASE; Ubiquitin conjugating system; Ubiquitin ligase P98170 331 Xq25 human T180-p 3801500 WPDYAHLtPRELASA BIR ubiquitination; enzymatic activity, induced TLE3(INDUCES) 29678905 1 3 1 required for the full activity of XIAP in the Wnt pathway, but not in the apoptotic pathway +Hnf4a HNF4 alpha DNA-binding; Nuclear receptor; Transcription factor P49698 15378 2 H3|2 84.32 cM mouse S143-p 458369 RISTRRSsYEDSSLP molecular association, regulation DNA(DISRUPTS) 28039934 4 3 12 bile acid biosynthesis +RPS20 RPS20 Ribosomal; Translation P60866 6224 8q12.1 human K8-ub 486915 MAFKDTGkTPVEPEV translation, altered 32324387 1 13 143 translational read-through of poly(A) mRNA sequence (KAAA) 20, ZNF598 plays a role in this process +STARD3 STARD3 Membrane protein, integral; Membrane protein, multi-pass Q14849 10948 17q12 human S209-p 12738027 LSEGQFYsPPESFAG MENTAL activity, induced; molecular association, regulation VAPA(INDUCES); VAPB(INDUCES); MOSPD2(INDUCES) 33124732; 35231443 2 4 0 +SLC6A3 DAT Membrane protein, integral; Membrane protein, multi-pass; Transporter; Transporter, SLC family Q01959 6531 5p15.33 human S2-p 451135 ______MsKSKCSVG activity, induced 16908408 2 0 0 stimulates DAT-mediated efflux of dopamine +ADRA1D ADRA1D GPCR, family 1; Membrane protein, integral; Membrane protein, multi-pass; Receptor, GPCR P25100 146 20p13 human S300-p 1424270001 KRERGKAsEVVLRIH 7tm_1 receptor internalization, altered signaling pathway regulation 29551601 1 1 0 regulates ERK signaling pathway, induces calcium signaling de-sensitization +IKBKG IKKG Adaptor/scaffold; Protein kinase, regulatory subunit Q9Y6K9 8517 Xq28 human K309-sm 2255103 KAQADIYkADFQAER CC2-LZ molecular association, regulation; intracellular localization apoptosis, inhibited; transcription, induced ATM(INDUCES) 14651848; 16906147; 18583959; 20065354 5 0 0 +Sod1 SOD1 Apoptosis; EC 1.15.1.1; Mitochondrial; Nuclear receptor co-regulator; Oxidoreductase P08228 20655 16 C3.3|16 51.56 cM mouse K123-ac 11317132 RTMVVHEkQDDLGKG Sod_Cu intracellular localization 28066183 2 8 2 +FAS FAS Apoptosis; Cell surface; Membrane protein, integral; Receptor, cytokine P25445 355 10q23.31 human Y91-p 473547 PCQEGKEyTDKAHFS TNFR_c6 intracellular localization apoptosis, altered 17195092 2 0 0 +PGK1 PGK1 Carbohydrate Metabolism - glycolysis and gluconeogenesis; EC 2.7.2.3; KINASE; Kinase, other P00558 5230 Xq21.1 human T243-p 2525475 IGGGMAFtFLKVLNN PGK molecular association, regulation; enzymatic activity, altered carcinogenesis, induced; cell growth, induced PDK1(INDUCES) 30029001 2 1 0 interaction increased by IL-6, and conditioned medium (CM) of THP-1 cells or M2 macrophages +PPARG PPAR-gamma DNA-binding; Nuclear receptor; Transcription factor P37231 5468 3p25.2 human Y102-p 9256871 YDLKLQEyQSAIKVE PPARgamma_N protein stabilization; ubiquitination cell differentiation, induced; transcription, induced PGC-1 alpha(INDUCES) 25368164 2 0 1 inhibits ubiquitination +Stat1 STAT1 DNA-binding; Transcription factor P42225 20846 1 C1.1|1 26.81 cM mouse R31-m1 476759 DSFPMEIrQYLAQWL STAT_int molecular association, regulation transcription, induced PIAS1(DISRUPTS); PTPN2(INDUCES) 12171910 2 0 0 modulates the duration of STAT1 Y701 phosphorylation +SGK3 SGK3 EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, AGC; Protein kinase, Ser/Thr (non-receptor) Q96BR1 23678 8q13.1 human S486-p 448196 DDAFVGFsYAPPSED Pkinase_C molecular association, regulation; enzymatic activity, induced ITCH(INDUCES); PDK1(INDUCES) 14604990; 16888620 5 0 0 CISK interaction with ITCH inhibits CXCR4 degradation. +XRCC5 Ku80 DNA-binding; EC 3.6.1.-; EC 3.6.4.-; Helicase; Nuclear receptor co-regulator; Nucleolus; RNA-binding P13010 7520 2q35 human K334-ub 12398993 DEEQMKYkSEGKCFS Ku molecular association, regulation DNA repair, induced DNA(DISRUPTS) 27895153 1 0 1 +Nr2c1 NR2C1 DNA-binding; Nuclear receptor Q505F1 22025 10 C2|10 48.81 cM mouse K238-sm 4258801 NIHPSGIkTEPAMLM activity, inhibited transcription, altered 18682553 2 0 0 +POLR2A POLR2A EC 2.7.7.48; EC 2.7.7.6; Nucleotide Metabolism - purine; Nucleotide Metabolism - pyrimidine; Transcription initiation complex; Transferase P24928 5430 17p13.1 human K1268-ub 21181946 IMNSDENkMQEEEEV RNA_pol_Rpb1_5; RNA_pol_Rpb1_7 intracellular localization DNA repair, induced; transcription, induced 32142649; 34108663; 34526721 3 8 0 ATPase activity to push Pol II backward and enable DNA repair, Pol II may resume transcription after DNA repair +FIRRM FIRRM Q9NSG2 55732 1q24.2 human S744-p 50774549 ETKNKVVsFLEKTGF molecular association, regulation PPP1CC(DISRUPTS) 34260926 1 3 0 +IRS4 IRS4 Adaptor/scaffold O14654 8471 Xq22.3 human S859-p 36276295 KDAASKPsGEGSFSK protein degradation; molecular association, regulation; ubiquitination carcinogenesis, altered; cell growth, inhibited; signaling pathway regulation CHIP(INDUCES) 30026872 1 1 0 +UBA52 UBA52 Ribosomal; Translation P62987 7311 19p13.11 human S65-p 9765474 DYNIQKEsTLHLVLR ubiquitin molecular association, regulation; protein conformation autophagy, induced UBA52(DISRUPTS) 36205098; 36469690 3 10 0 induces mitophagy +SKP1 SKP1A Cell cycle regulation; Ubiquitin conjugating system P63208 6500 5q31.1 human T131-p 4785800 ANMIKGKtPEEIRKT Skp1 protein degradation; molecular association, regulation; ubiquitination; intracellular localization 14-3-3 sigma(INDUCES) 30728155 1 32 2 14-3-3 sigma compete with FBW7 for binding with SKP1A; effect of protein function is interaction dependent +SLC9A1 NHE1 Membrane protein, integral; Membrane protein, multi-pass; Motility/polarity/chemotaxis; Transporter; Transporter, SLC family P19634 6548 1p36.11 human T779-p 3914103 PGTDDVFtPAPSDSP activity, induced 23678047 2 5 2 +NR1I2 PXR DNA-binding; Nuclear receptor O75469 8856 3q13.33 human S114-p 30259801 MKKEMIMsDEAVEER molecular association, regulation transcription, inhibited DNA(DISRUPTS) 24184507 1 1 0 +IRS4 IRS4 Adaptor/scaffold O14654 8471 Xq22.3 human Y847-p 1877150802 GLDKEVSyNWDPKDA molecular association, regulation cell cycle regulation; carcinogenesis, induced; cell growth, induced EBNA1BP2(INDUCES) 35550247 1 1 0 +RETREG1 FAM134B Membrane protein, integral; Membrane protein, multi-pass Q9H6L5 54463 5p15.1 human S151-p 2509195 AQLWRSLsESWEVIN Reticulon molecular association, regulation autophagy, induced; apoptosis, induced FAM134B(INDUCES) 31930741; 37043189 2 6 0 +Arhgap12 ARHGAP12 GAP; GAP, Rac/Rho Q8C0D4 75415 18|18 A1 mouse T229-p 451930 TEQMRATtPPNQGRP SH3-WW_linker cell cycle regulation; cell motility, altered 18515860 0 37 43 +Htt Huntingtin Cytoskeletal P42859 15194 5 B2|5 17.92 cM mouse S13-p 10206805 KLMKAFEsLKSFQQQ protein degradation autophagy, induced; transcription, induced 31088970 19 3 0 +TGFBR3 TGFBR3 Membrane protein, integral Q03167 7049 1p22.1 human S831-p 23940713 SPPASENsSAAHSIG molecular association, regulation TRAF6(INDUCES) 22427868 1 0 0 +Nfatc2 NFAT1 DNA-binding; Transcription factor Q60591 18019 2 H3|2 88.91 cM mouse K897-ub 1852795100 LPTGVTVkQEQNLDQ protein degradation 21628454 1 0 0 in NFAT1 S215/219/223A triple mutant or when phosphorylation of those sites is inhibited by zoledronic acid +TTK TTK Cancer Testis Antigen (CTA); EC 2.7.12.1; KINASE; Kinase, protein; Protein kinase, Other; Protein kinase, dual-specificity (non-receptor) P33981 7272 6q14.1 human S7-p 4272730 _MESEDLsGRELTID intracellular localization cell cycle regulation 25265012; 36395767 2 6 0 autophosphorylation of this site is required for release TTK from kinetochore; causes decreased kinetochore localization of BubR1 and Mad2. +APBA2 APBA2 Adaptor/scaffold Q99767 321 15q13.1 human S238-p 7151800 AEIKMSLsMTSITSA molecular association, regulation APP(INDUCES) 19222704 1 1 0 +GAB2 GAB2 Adaptor/scaffold Q9UQC2 9846 11q14.1 human Y584-p 448385 SGDSEENyVPMQNPV molecular association, regulation PIK3R1(INDUCES) 11334882 1 0 0 +RAF1 RAF1 EC 2.7.11.1; KINASE; Kinase, protein; Oncoprotein; Protein kinase, Ser/Thr (non-receptor); Protein kinase, TKL P04049 5894 3p25.2 human S621-p 447746 PKINRSAsEPSLHRA molecular association, regulation; enzymatic activity, inhibited; protein conformation; phosphorylation; enzymatic activity, induced cell growth, altered 14-3-3 beta(INDUCES); 14-3-3 zeta(INDUCES) 10801873; 10998357; 18775988; 19595761; 19933846; 8816453 24 70 10 +PHGDH PHGDH Amino Acid Metabolism - glycine, serine and threonine; Cell development/differentiation; EC 1.1.1.95; Oxidoreductase O43175 26227 1p12 human K310-ub 1883421300 FVDMVKGkSLTGVVN protein degradation 35788583 1 0 0 +DOK1 DOK1 Adaptor/scaffold; Motility/polarity/chemotaxis Q99704 1796 2p13.1 human S446-p 454884 SGIKSHNsALYSQVQ cell motility, induced; cell growth, inhibited 15574499 1 2 24 +Cftr CFTR Channel, chloride; EC 3.6.3.49; Hydrolase; Membrane protein, integral; Membrane protein, multi-pass; Transporter; Transporter, ABC family P26361 12638 6 A2|6 8.1 cM mouse S670-p 3333405 TETLRRFsVDDSSAP CFTR_R protein conformation 19927121 1 3 0 in vitro +Camk2b CAMK2B EC 2.7.11.17; KINASE; Kinase, protein; Protein kinase, CAMK; Protein kinase, Ser/Thr (non-receptor) P28652 12323 11 A1|11 3.89 cM mouse S315-p 451707 MLATRNFsVGRQTTA cytoskeletal reorganization 28607044 4 17 4 interferes with its F-actin bundling and suppresses the excess spine formation and elongation in Purkinje cells +Trpv2 TRPV2 Channel, cation; Membrane protein, integral; Membrane protein, multi-pass Q9WUD2 29465 10q23 rat S37-p 8110156 QEPPPMEsPFQREDR cell growth, induced 26416880 1 3 3 neurite outgrowth +PLXNB1 PLXNB1 Membrane protein, integral; Motility/polarity/chemotaxis; Receptor, misc. O43157 5364 3p21.31 human Y1708-p 3413438 DSVGEPLyMLFRGIK Plexin_cytopl molecular association, regulation cell motility, altered GRB2(INDUCES); PLCG1(INDUCES); PLCG2(INDUCES) 19805522 1 1 1 +Eif3f eIF3-epsilon EC 3.4.19.12; Translation; Translation initiation Q9DCH4 66085 7|7 E3 mouse K357-ub 7388004 SQIALNEkLVNL___ MitMem_reg protein degradation 19073596 1 0 0 regulates skeletal muscle atrophy +Sting1 STING Apoptosis; Endoplasmic reticulum; Membrane protein, integral; Membrane protein, multi-pass; Mitochondrial Q3TBT3 72512 18 B2|18 mouse S365-p 31064700 QEPRLLIsGMDQPLP transcription, induced; transcription, inhibited; transcription, altered; signaling pathway regulation 30135079; 33785602; 34901991; 35613599 35 3 0 +FOXL2 FOXL2 DNA-binding; Transcription factor P58012 668 3q22.3 human S33-p 21697903 EPEGPPPsPGKGGGG sumoylation; protein degradation; protein stabilization; molecular association, regulation; ubiquitination; intracellular localization carcinogenesis, induced; apoptosis, inhibited; transcription, inhibited UBC9(DISRUPTS); MDM2(INDUCES) 22022399; 24390485 3 9 1 sumoylation and protein stability is induced in FOXL2 wt cells; in patients carrying FOXL2 C134 mutantion +LRP2 LRP2 Membrane protein, integral; Motility/polarity/chemotaxis; Receptor, misc. P98164 4036 2q31.1 human S4627-p 767903 PAKPKPPsRRDPTPT receptor internalization, altered; receptor recycling, altered 17555532 1 1 0 +Myo3a MYO3A Actin-binding; EC 2.7.11.1; KINASE; Kinase, protein; Motor; Protein kinase, STE; Protein kinase, Ser/Thr (non-receptor) Q8K3H5 667663 2|2 A3 mouse T184-p 29674700 STRHRLNtSVGTPFW Pkinase enzymatic activity, induced 21895655 3 3 0 +NOX5 NOX5 iso4 EC 1.6.3.-; Membrane protein, integral; Membrane protein, multi-pass; Oxidoreductase Q96PH1-4 79400 15q23 human S498-p 472626 RSVTMRKsQRSSKGS FAD_binding_8 activity, induced; enzymatic activity, induced 17164239; 21297032; 24505490; 24992705 5 0 0 +AKT1 Akt1 EC 2.7.11.1; KINASE; Kinase, protein; Oncoprotein; Protein kinase, AGC; Protein kinase, Ser/Thr (non-receptor) P31749 207 14q32.33 human K214-ub 1877462100 HPFLTALkYSFQTHD Pkinase protein degradation; molecular association, regulation autophagy, induced GRP78(INDUCES) 32164484 1 0 0 HSPA5 arginylation, modulated by ATE1 +Calm1 Calmodulin Calcium-binding; Protein phosphatase, regulatory subunit P0DP29 24242 6q32 rat S102-p 448706 KDGNGYIsAAELRHV EF-hand_7 molecular association, regulation; activity, inhibited KCNQ4(INDUCES) 24627475; 8206911 7 27 40 T80 site is key to binding. CAM phosphorylation regulates channel trafficking and stabilizes activity-thereby regulating neuronal excitability.; Calmodulin phosphorylated by CKII in vitro showed reduced activation of erythrocyte plasma membrane Ca2+ pump. +Scnn1g ENaC-gamma Channel, sodium; Membrane protein, integral; Membrane protein, multi-pass; Transporter, ion channel P37091 24768 1q36 rat K13-ub 486254 KIKAKIKkNLPVRGP receptor recycling, inhibited; protein degradation; intracellular localization 9351815 1 0 0 +NR4A1 Nur77 Apoptosis; DNA-binding; Nuclear receptor P22736 3164 12q13.13 human T143-p 15068600 CSAPSPStPSFQPPQ sumoylation; protein stabilization; intracellular localization autophagy, induced 22234305; 32210435 3 0 0 +PRDX1 PRDX1 EC 1.11.1.15; Nuclear receptor co-regulator; Oxidoreductase Q06830 5052 1p34.1 human T90-p 455554 CHLAWVNtPKKQGGL AhpC-TSA molecular association, regulation; enzymatic activity, inhibited; protein conformation PRDX1(INDUCES) 11986303; 16376335; 23386615 4 2 0 +BNIP3L BNIP3L Apoptosis; Endoplasmic reticulum; Membrane protein, integral; Mitochondrial; Nuclear envelope O60238 665 8p21.2 human S34-p 65958200 PPPAGLNsSWVELPM BNIP3 molecular association, regulation autophagy, induced LC3B(INDUCES) 28442745 1 0 0 +TCOF1 treacle Nucleolus; RNA-binding; Transcription, coactivator/corepressor Q13428 6949 5q32-q33.1 human T210-p 35530406 TSSSSDEtDVEGKPS molecular association, regulation NBS1(INDUCES) 25064736 1 1 0 downregulation of rRNA transcription due to the interaction with NBS1 in response to DNA damage. +SORBS2 ArgBP2 iso2 Adaptor/scaffold; Motility/polarity/chemotaxis O94875-2 8470 4q35.1 human Y573-p 11057708 NTKGAEDyPDPPIPH protein conformation 24475245 1 0 2 reduced self-interaction +GJA1 GJA1 Channel, misc.; Membrane protein, integral; Membrane protein, multi-pass; Motility/polarity/chemotaxis P17302 2697 6q22.31 human S365-p 459207 IVDQRPSsRASSRAS protein conformation 23828237 15 15 2 +MCM2 MCM2 DNA-binding; EC 3.6.4.12 P49736 4171 3q21.3 human S5-p 2201405 ___MAESsESFTMAS intracellular localization 19647517 2 12 0 promotes Mcm2 loading onto chromatin +DYRK3 DYRK3 EC 2.7.12.1; KINASE; Kinase, protein; Protein kinase, CMGC; Protein kinase, dual-specificity (non-receptor) O43781 8444 1q32.1 human S350-p 23101265 LKHHGRSsTKVIDFG Pkinase protein stabilization; enzymatic activity, induced 29634919 1 1 1 +Pde4b PDE4B EC 3.1.4.53; Nucleotide Metabolism - purine; Phosphodiesterase Q8VBU5 18578 4 C6|4 46.99 cM mouse S304-p 4765135 KKLMHSSsLNNTSIS enzymatic activity, induced 26952277 1 9 13 +DUSP12 DUSP12 EC 3.1.3.16; EC 3.1.3.48; Motility/polarity/chemotaxis; PHOSPHATASE; Protein phosphatase, dual-specificity Q9UNI6 11266 1q23.3 human S335-p 3851464 KILPVLGsQTGKI__ intracellular localization cell cycle regulation 21521943 1 2 5 +Th TH Amino Acid Metabolism - tyrosine; EC 1.14.16.2; Endoplasmic reticulum; Mitochondrial; Oxidoreductase; Vesicle P04177 25085 1q41 rat S19-p 448542 KGFRRAVsEQDAKQA TOH_N protein stabilization; molecular association, regulation; protein conformation; enzymatic activity, induced 14-3-3 theta(INDUCES) 10820208; 11502746; 14675149; 15228599; 15639226; 9751201 46 9 4 +XRCC5 Ku80 DNA-binding; EC 3.6.1.-; EC 3.6.4.-; Helicase; Nuclear receptor co-regulator; Nucleolus; RNA-binding P13010 7520 2q35 human K202-ub 15391490 KGITEQQkEGLEIVK Ku_N molecular association, regulation DNA repair, induced DNA(DISRUPTS) 27895153 1 6 1 +EGLN1 EGLN1 EC 1.14.11.29; Oxidoreductase Q9GZT9 54583 1q42.2 human K297-m1 1883819300 YKINGRTkAMVACYP enzymatic activity, inhibited cell growth, induced; signaling pathway regulation 35452683 1 1 0 K297 methylation attenuates its effect on HIF1a-mediated hypoxia signaling; the prolyl hydroxylase activity of EGLN1 is inhibited +FOXM1 FOXM1 iso2 DNA-binding; Transcription factor Q08050-2 2305 12p13.33 human K218-sm 31898504 HLEQRQVkVEEPSRP protein degradation transcription, inhibited 25533473 2 0 0 +MYC Myc DNA-binding; Nucleolus; Oncoprotein; Transcription factor P01106 4609 8q24.21 human S86-p 449991 SRRSGLCsPSYVAVT Myc_N protein stabilization; phosphorylation apoptosis, altered; carcinogenesis, inhibited; cell growth, induced; apoptosis, induced; apoptosis, inhibited; transcription, induced; transcription, inhibited 10551811; 11243879; 24030976; 25109329; 33461590 7 12 0 inhibits phosphorylation at T58 +ATG13 ATG13 Autophagy; Vesicle O75143 9776 11p11.2 human S224-p 53377101 DRPYPSSsPMHPCNY cell cycle regulation; autophagy, induced; cell growth, induced 32516310 2 2 0 +CACNA1C CACNA1C Channel, calcium; Membrane protein, integral; Membrane protein, multi-pass Q13936 775 12p13.33 human Y1920-p 1043300 ETSQDETyEVKMNHD activity, induced 17942635 2 0 1 Ca(2+) currents +Foxp3 FOXP3 C2H2-type zinc finger protein; Cell cycle regulation; DNA-binding; Transcription factor Q99JB6 20371 X A1.1|X 3.41 cM mouse K31-ac 25614402 PSWKTAPkGSELLGT protein stabilization; ubiquitination cell differentiation, induced 22312127 2 1 0 inhibits ubiquitination +MAZ MAZ C2H2-type zinc finger protein; RNA-binding; Transcription factor P56270 4150 16p11.2 human T72-p 451250 AAPAPPPtPQAPAAE activity, induced transcription, induced 11809795 1 0 0 +FKBP1A FKBP12 EC 5.2.1.8; Isomerase P62942 2280 20p13 human K35-ub 3931455 TGMLEDGkKFDSSRD FKBP_C protein conformation 31375563 1 3 19 Partially unfolded but not aggregated drives FKBP12 ubiquitylation at the proteasome +Notch1 Notch 1 Membrane protein, integral; Motility/polarity/chemotaxis; Oncoprotein; Receptor, misc.; Transcription factor Q01705 18128 2 A3|2 18.91 cM mouse R2317-m2 56852201 PSQYNPLrPGVTPGT activity, induced; protein degradation; ubiquitination transcription, induced 25805888 1 1 0 +Syp SYP Membrane protein, integral; Membrane protein, multi-pass; Vesicle P07825 24804 Xq12 rat Y273-p 10769104 QGGYQPDyGQPASGG molecular association, regulation LYN(INDUCES); Src(INDUCES) 23103755 1 1 0 +Tlr3 TLR3 Membrane protein, integral; Receptor, cytokine Q99MB1 142980 8|8 B1.1 mouse Y760-p 450187 EQFEYTAyIIHAHKD TIR cell growth, induced; transcription, induced 24526685 4 0 0 +Rlim RNF12 EC 6.3.2.-; Ligase; Transcription, coactivator/corepressor; UBIQUITIN LIGASE; Ubiquitin conjugating system; Ubiquitin ligase Q9WTV7 19820 X 46.42 cM|X D mouse S214-p 18014966 QRRARSRsPEHRRTR intracellular localization cell motility, induced; apoptosis, inhibited 23904271 1 0 0 phosphorylated S214 (human) or S215 (murine) RNF12 is localized in nucleus; shuttling of RNF12 is important for promoting cell motility and alveolar cell survival +CASP9 CASP9 Apoptosis; EC 3.4.22.62; Protease P55211 842 1p36.21 human S196-p 448454 KLRRRFSsLHFMVEV Peptidase_C14 activity, inhibited apoptosis, induced; apoptosis, inhibited 34705620; 9812896 4 1 0 +Glp1r GLP1R GPCR, family 2; Membrane protein, integral; Membrane protein, multi-pass; Receptor, GPCR P32301 25051 20p12 rat S444-p 451382 KCPTSSVsSGATVGS receptor desensitization, altered 8702711 1 0 0 +CALR Calreticulin ACETYLTRANSFERASE; Acetyltransferase; Calcium-binding; Motility/polarity/chemotaxis; Nuclear receptor co-regulator; Secreted; Secreted, signal peptide P27797 811 19p13.13 human K48-ac 4219810 KHKSDFGkFVLSSGK Calreticulin protein conformation 18795239 1 4 1 +TTK TTK Cancer Testis Antigen (CTA); EC 2.7.12.1; KINASE; Kinase, protein; Protein kinase, Other; Protein kinase, dual-specificity (non-receptor) P33981 7272 6q14.1 human T45-p 1880463702 LNKISADtTDNSGTV intracellular localization 36395767 1 0 0 +Chpt1 CHPT1 EC 2.7.8.2; Lipid Metabolism - ether lipid; Lipid Metabolism - glycerophospholipid; Membrane protein, integral; Membrane protein, multi-pass; Transferase Q8C025 212862 10|10 C1 mouse K254-ub 12718513 ILHGGVGkNGSTIAG protein degradation; enzymatic activity, inhibited 20018880 1 0 0 +LALBA LALBA Apoptosis; Secreted; Secreted, signal peptide; Transferase P00711 281894 cow T48-p 1875112303 SLPEWVCtTFHTSGY Lys molecular association, regulation; protein conformation IGE(DISRUPTS); IgG(DISRUPTS) 34655828 0 1 0 +OPRM1 MOR-1 GPCR, family 1; Membrane protein, integral; Membrane protein, multi-pass; Receptor, GPCR P35372 4988 6q25.2 human T372-p 447785 STRIRQNtRDHPSTA receptor internalization, altered 18463167 19 5 0 +NR5A1 STF-1 Nuclear receptor; Transcription, coactivator/corepressor Q13285 2516 9q33.3 human K34-ac 458972 LLTCESCkGFFKRTV zf-C4 protein stabilization; intracellular localization transcription, induced 11479297 1 0 0 localization to the cytoplasm +CYCS CYCS Apoptosis; Mitochondrial; Oxidoreductase; PHOSPHATASE; Protein phosphatase, Ser/Thr (non-receptor) P99999 54205 7p15.3 human K8-ac 1968624 MGDVEKGkKIFIMKC Cytochrom_C molecular association, regulation; protein conformation 34455704 1 1 0 loss of positive potential at the surface areas around the mutated residue, thermal stability of Cc species is slightly changed, local structural changes, and increased binding afinity for the Cc1-Cc complex for the K8 mutants +RUNX1 AML1 DNA-binding; Oncoprotein; Transcription factor Q01196 861 21q22.12 human K125-ub 15384401 RNATAAMkNQVARFN Runt protein degradation; intracellular localization carcinogenesis, inhibited; cell growth, inhibited; transcription, inhibited 28536267 1 4 2 +Trpm7 ChaK1 Channel, cation; EC 2.7.11.1; KINASE; Kinase, protein; Membrane protein, integral; Membrane protein, multi-pass; Protein kinase, Ser/Thr (non-receptor); Protein kinase, atypical Q923J1 58800 2|2 F1 mouse S1360-p 31909861 ALFPSAVsPPELRQR protein stabilization; intracellular localization 29866880 1 4 0 regulates proteosome-mediated turnover +CDKN1A p21Cip1 Cell cycle regulation; Inhibitor P38936 1026 6p21.2 human S130-p 455618 SGEQAEGsPGGPGDS protein degradation; molecular association, regulation; protein stabilization; ubiquitination; intracellular localization; phosphorylation cell cycle regulation CDK4(DISRUPTS); CDK2(DISRUPTS); CCND1(DISRUPTS) 12058028; 15964852; 16508017; 19364816; 22227330; 23737759; 27384476 11 11 7 +NHE-3 NHE3 Membrane protein, integral; Membrane protein, multi-pass; Transporter; Transporter, SLC family P26432 100009430 rabbit S526-p 31839902 MRQSAQKsRDRILNV activity, induced; molecular association, regulation; intracellular localization; phosphorylation Ezrin(INDUCES) 24398676 1 0 0 stimulates Akt to phosphorylate S515 +CENPA CENPA DNA-binding P49450 1058 2p23.3 human S17-p 485047 PEAPRRRsPSPTPTP Histone protein conformation cell cycle regulation 23818633 2 30 7 chromosome segregation +PIAS1 PIAS1 EC 6.3.2.-; Nuclear receptor co-regulator; SUMO LIGASE; SUMO conjugating system; SUMO ligase; Transcription, coactivator/corepressor O75925 8554 15q23 human K137-sm 55435676 HPVHPDIkLQKLPFY PINIT intracellular localization 32047143 1 3 0 +TP53 p53 Activator; DNA-binding; Motility/polarity/chemotaxis; Nuclear receptor co-regulator; Transcription factor; Tumor suppressor P13481 green monkey S15-p 447490 PSIEPPLsQETFSDL P53_TAD molecular association, regulation BLM(INDUCES); ATRX(INDUCES); MRE11A(INDUCES); RAD51(INDUCES) 15806145 480 12 0 +Cacnb2 CACNB2 Channel, calcium Q8VGC3 116600 17q12.3 rat S529-p 1868239900 KKSQHRSsSATHQNH activity, induced 10567342 4 0 0 +SMAD2 SMAD2 DNA-binding; Transcription factor Q15796 4087 18q21.1 human S465-p 447494 SPSVRCSsMS_____ activity, induced; molecular association, regulation; intracellular localization carcinogenesis, induced; cell differentiation, induced; transcription, induced; transcription, altered TGFBR1(DISRUPTS); SMAD4(INDUCES) 11043574; 21996745; 31995604; 33963314; 35075279; 36461015; 8980228; 9346908; 9346966 57 1 5 S464 not likely phosphorylated but is required for efficient phosphorylation of COOH terminus. +Gabrg2 GABRG2 Channel, chloride; Channel, ligand-gated; Membrane protein, integral; Membrane protein, multi-pass; Transporter; Transporter, ion channel P22723 14406 11 A5|11 24.8 cM mouse K363-ub 11956712 HYFVSNRkPSKDKDK Neur_chan_memb protein degradation; receptor internalization, altered 19815531 1 0 0 regulation of the late endosomal/lysosomal trafficking of GABA receptors, regulation of synaptic transmission +Zdhhc3 ZDHHC3 EC 2.3.1.225; Membrane protein, integral; Membrane protein, multi-pass; Transferase Q8R173 69035 9|9 F4 mouse Y295-p 464577 DQGKADPyQYVV___ enzymatic activity, inhibited cytoskeletal reorganization 27247265 1 0 31 neurite outgrowth; palmitoylation +RYR2 RYR2 Channel, ligand-gated; Membrane protein, integral; Membrane protein, multi-pass; Transporter; Transporter, ion channel P30957 rabbit S2815-p 458801 ISQTSQVsVDAAHGY activity, inhibited 21555709 63 8 5 inhibits SERCA2 activity +NCAPH NCAPH Cell cycle regulation Q15003 23397 2q11.2 human S570-p 470129 PGLQAADsDDEDLDD Cnd2 phosphorylation chromatin organization, altered 17066080 1 1 3 The phosphorylation of this site was half as strong in mitosis as compared to interphase NCAPH. This CK2 mediated site was dephosphorylated efficiently only on mitotic chromosomes.Dephosphorylation also occured using purified human condensin with Xenopus egg extract. Dephosphorylation of CK2 specific sites greatly increases supercoiling activity of NCAPH. Chromosome length in CK2 supplemented extracts was two-fold longer than in control extracts. +Incenp INCENP Cell cycle regulation; EC 2.7.11.1 Q9WU62 16319 19 A|19 6.1 cM mouse T388-p 458333 ATKIAIStPTSKPAA molecular association, regulation cell cycle regulation PLK1(INDUCES) 16378098 1 0 1 phosphorylation plays important role in recruitment of Plk1 to kinetochores and progression of cell cycle +KCNA2 Kv1.2 Channel, potassium; Membrane protein, integral; Membrane protein, multi-pass P16389 3737 1p13.3 human Y415-p 455552 VIVSNFNyFYHRETE Ion_trans molecular association, regulation Cortactin(DISRUPTS) 12151401 1 0 1 +CRTC1 TORC1 iso2 Transcription factor Q6UUV9-2 23373 19p13.11 human S346-p 15412157 QQASPTLsPLSPITQ protein degradation transcription, inhibited 29408765 1 0 3 +Grk2 GRK2 EC 2.7.11.15; KINASE; Kinase, protein; Protein kinase, AGC; Protein kinase, Ser/Thr (non-receptor) P26817 25238 1q43 rat S29-p 447724 ATPAARAsKKILLPE intracellular localization; enzymatic activity, induced 20194499 2 0 0 +Srrm2 SRm300 RNA splicing; RNA-binding; Spliceosome Q8BTI8 75956 17|17 A3.3 mouse S1068-p 453278 GSLSRSSsPVTELTA protein degradation; molecular association, regulation; intracellular localization CCTA(DISRUPTS) 30283027 1 82 18 changes the subcellular localization of SRm300 from the nucleus to the cytoplasm +Cbx1 CBX1 Transcription factor P83917 12412 11 D|11 60.11 cM mouse T51-p 2753801 GFSDEDNtWEPEENL Chromo molecular association, regulation; intracellular localization DNA(DISRUPTS) 19657222 2 0 0 +TERF1 TRF1 DNA-binding P54274 7013 8q21.11 human S114-p 63083903 AIIHGLSsLTACQLR TRF protein stabilization; molecular association, regulation TINF2(INDUCES); FBXO4(DISRUPTS) 28216227 1 1 0 Increased Interaction with Tin2, Increased cell survival and telomere protection +ULK1 ULK1 Autophagy; EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, Other; Protein kinase, Ser/Thr (non-receptor) O75385 8408 12q24.33 human T1046-p 10428800 RRLSALLtGICA___ DUF3543 protein degradation; molecular association, regulation autophagy, inhibited KLHL20(INDUCES) 26687681 2 2 0 +CENATAC CENATAC Q86UT8 338657 11q23.3 human K31-ac 27584361 RKHQRQLkEALERLL CCDC84 molecular association, regulation 31722219 1 2 0 acetylated CCDC84 promotes HsSAS-6 ubiquitination by enhancing the binding af?nity of HsSAS-6 for Cdh1; regulates centrosome number +NKX3-1 NKX3-1 DNA-binding; Transcription factor; Tumor suppressor Q99801 4824 8p21.2 human T134-p 28750701 SRAAFSHtQVIELER Homeodomain protein degradation; ubiquitination 23890999 1 0 0 +Klf4 KLF4 C2H2-type zinc finger protein; DNA-binding; Transcription factor Q60793 16600 4 B3|4 29.76 cM mouse S132-p 24976100 ASASSSSsPASSGPA protein degradation; molecular association, regulation; ubiquitination; intracellular localization cell differentiation, induced; transcription, inhibited Exportin-1(INDUCES); ERK2(INDUCES); FBW1B(INDUCES) 22307056; 29526737; 31221664 3 0 0 nuclear export; dephosphorylation causes nuclear localization and hence stability; Nanog and Klf4 transcription inhibited +Syngap1 SynGAP iso3 GAP; GAP, Ras Q9QUH6-3 192117 20p12 rat S783-p 18710212 LSVNKSVsMLDLQGD DUF3498 molecular association, regulation; intracellular localization HRas(INDUCES) 21382555 1 2 1 +MAPK11 P38B EC 2.7.11.24; KINASE; Kinase, protein; Protein kinase, CMGC; Protein kinase, Ser/Thr (non-receptor) Q15759 5600 22q13.33 human T241-p 54390600 RIMEVVGtPSPEVLA Pkinase cell differentiation, induced 26976637 1 1 0 +OXSR1 OSR1 EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, STE; Protein kinase, Ser/Thr (non-receptor) O95747 9943 3p22.2 human S325-p 456504 VRRVPGSsGRLHKTE activity, induced; enzymatic activity, induced 18270262; 29581290 14 12 0 2.5-fold increase in Kir2.1 channel activity when cotransfected compared to Kir2.1 alone +NDC80 HEC1 Cell cycle regulation O14777 10403 18p11.32 human S76-p 459765 SQLGIFSsSEKIKDP Ndc80_HEC cytoskeletal reorganization 35878017 1 2 0 +FOXA1 FOXA1 DNA-binding; Transcription factor P55317 3169 14q21.1 human K270-me 1877309700 QKRFKCEkQPGAGGG protein degradation chromatin organization, altered DNA(DISRUPTS) 32868907 1 1 0 AR chromatin recruitment is impaired +Dcx Doublecortin Cytoskeletal; Motility/polarity/chemotaxis O88809 13193 X|X F2 mouse S332-p 451363 STPKSKQsPISTPTS intracellular localization cell motility, altered; cell growth, altered TUBB(DISRUPTS) 20715151 7 4 14 +NANOG NANOG Cell development/differentiation; DNA-binding; Transcription factor Q9H9S0 79923 12p13.31 human S68-p 1394461701 LIQDSPDsSTSPKGK protein stabilization; molecular association, regulation cell growth, induced; transcription, induced SPOP(DISRUPTS) 30595535 1 0 0 +EZH2 EZH2 EC 2.1.1.43; METHYLTRANSFERASE; Methyltransferase; Methyltransferase, protein lysine Q15910 2146 7q36.1 human K421-m1 1883327700 CQTPIKMkPNIEPPE protein degradation cell growth, inhibited; cell motility, inhibited 36127410 1 0 0 promotes M2 macrophage polarization +KCNJ1 ROMK Channel, potassium; Membrane protein, integral; Membrane protein, multi-pass P48048 3758 11q24.3 human S219-p 2461201 RVANLRKsLLIGSHI IRK_C activity, induced; protein conformation; activity, inhibited 18547545; 18571730; 18620882 5 0 0 +MAPK3 ERK1 EC 2.7.11.24; KINASE; Kinase, protein; Protein kinase, CMGC; Protein kinase, Ser/Thr (non-receptor) P27361 5595 16p11.2 human K72-ac 1873356102 KTRVAIKkISPFEHQ Pkinase enzymatic activity, inhibited; protein conformation; phosphorylation transcription, inhibited 29259132 1 1 0 Inhibits phosphorylation +VAV1 VAV1 GEF; GEF, Rac/Rho; Motility/polarity/chemotaxis; Oncoprotein P15498 7409 19p13.3 human Y160-p 447865 VEEDEDLyDCVENEE molecular association, regulation; activity, inhibited cell motility, induced; cytoskeletal reorganization; cell adhesion, altered ITGB3(INDUCES); PLCG1(INDUCES); Lck(INDUCES); PIK3R1(INDUCES) 15699036; 17050525; 29058761 9 2 0 regulates Cdc42 activation. ; neutrophil crawling behavior +ANXA1 ANXA1 Calcium-binding; Lipid-binding P04083 301 9q21.13 human S27-p 447972 EYVQTVKsSKGGPGS molecular association, regulation; intracellular localization carcinogenesis, induced; exocytosis, altered; exocytosis, induced; cytoskeletal reorganization FPR2(INDUCES) 11482905; 19625660; 27634935; 32133417; 34944403 8 0 0 +TRAF4 TRAF4 Adaptor/scaffold; DNA-binding; UBIQUITIN LIGASE; Ubiquitin conjugating system; Ubiquitin ligase Q9BUZ4 9618 17q11.2 human S426-p 3211032 KPGTWRGsLDESSLG protein stabilization signaling pathway regulation 22547678 1 30 9 negative regulator of an innate immune signaling pathway +GRK2 GRK2 EC 2.7.11.15; KINASE; Kinase, protein; Protein kinase, AGC; Protein kinase, Ser/Thr (non-receptor) P21146 282682 cow S670-p 447725 KMKNKPRsPVVELSK activity, inhibited 10574913 5 40 18 +IKBKB IKKB EC 2.7.11.10; KINASE; Kinase, protein; Protein kinase, Other; Protein kinase, Ser/Thr (non-receptor) O14920 3551 8p11.21 human S740-p 5014909 SFTALDWsWLQTEEE IKKbetaNEMObind molecular association, regulation IKKG(DISRUPTS) 18957422 1 1 0 +HDAC2 HDAC2 DEACETYLASE; Deacetylase; EC 3.5.1.98; Nuclear receptor co-regulator; Transcription, coactivator/corepressor Q92769 3066 6q21 human S422-p 467979 IACDEEFsDSEDEGE molecular association, regulation; acetylation; enzymatic activity, inhibited p53(INDUCES); HDAC1(INDUCES) 20388487 3 77 49 +ATF2 ATF-2 ACETYLTRANSFERASE; C2H2-type zinc finger protein; EC 2.3.1.48; Transcription factor P15336 1386 2q31.1 human S121-p 6406001 LATPIIRsKIEEPSV intracellular localization transcription, induced 19176525 1 0 0 plays a role in the regulation of both TPA- and c-Jun-dependent transcription +SRC Src EC 2.7.10.2; KINASE; Kinase, protein; Oncoprotein; Protein kinase, TK; Protein kinase, tyrosine (non-receptor) P12931 6714 20q11.23 human Y530-p 448235 FTSTEPQyQPGENL_ protein degradation; molecular association, regulation; enzymatic activity, inhibited; protein processing; enzymatic activity, induced; phosphorylation; activity, induced; intracellular localization; protein conformation carcinogenesis, induced; carcinogenesis, inhibited; cell growth, inhibited; cell motility, induced; cell motility, inhibited; signaling pathway regulation; cell adhesion, inhibited; cell growth, induced Src(INDUCES); TM4SF5(INDUCES); FBXL7(DISRUPTS) 11035005; 12052863; 14506284; 16790421; 18454177; 20615878; 21399647; 21442427; 21873224; 23453597; 23471971; 23532252; 24300854; 24931162; 25386896; 32839549; 33761359; 34335982; 34385357; 34606417; 35293964; 35697802; 36765146; 37428018; 9655255 153 24 968 inhibits phosphorylation of FAK, p130Cas, and paxillin +Nlgn1 NLGN1 Membrane protein, integral Q99K10 192167 3|3 A3 mouse Y782-p 1008111 RTACPPDyTLAMRRS molecular association, regulation; intracellular localization neural plasticity; cell differentiation, induced gephyrin(DISRUPTS); PSD-95(DISRUPTS) 30266896; 32324534 3 1 0 regulates AMPAR recruitment; long-term potentiation (LTP), dendritic spine formation +APPL1 APPL Adaptor/scaffold; Nuclear receptor co-regulator Q9UKG1 26060 3p14.3 human S410-p 25802100 SFQQRHEsLRPAAGQ molecular association, regulation; receptor recycling, induced; receptor recycling, altered endocytosis, inhibited OCRL(DISRUPTS) 17765681; 29212031 2 3 0 +SNRNP70 snRNP 70 RNA splicing; RNA-binding; Spliceosome P08621 6625 19q13.33 human S140-p 2103618 HMVYSKRsGKPRGYA RRM_1 molecular association, regulation; intracellular localization apoptosis, induced; cell growth, altered HLA-DQB1(INDUCES) 12548559; 18202700 2 0 1 present in apoptotic bodies; Phosphorylated peptide S140-P induced CD4+ Tcell proliferation and IL-2 secretion in MLR/lpr mice. +NOTCH1 Notch 1 Membrane protein, integral; Motility/polarity/chemotaxis; Oncoprotein; Receptor, misc.; Transcription factor P46531 4851 9q34.3 human T2511-p 483083 VPEHPFLtPSPESPD protein degradation; molecular association, regulation; ubiquitination; activity, inhibited carcinogenesis, altered; carcinogenesis, inhibited; cell growth, inhibited; cell motility, altered; cell motility, inhibited; transcription, inhibited; signaling pathway regulation FBXW7(INDUCES) 25344755; 27335110; 27806347; 31605148 5 1 0 triggers degradation by FBXW7; Notch1 signaling pathway regulation +Prkci PKCI Cell adhesion; Cell development/differentiation; EC 2.7.11.13; KINASE; Kinase, protein; Motility/polarity/chemotaxis; Oncoprotein; Protein kinase, AGC; Protein kinase, Ser/Thr (non-receptor); Tumor suppressor F1M7Y5 84006 2q24 rat Y334-p 450074 RLFFVIEyVNGGDLM Pkinase activity, induced 11713277 1 0 0 +Map3k12 DLK EC 2.7.11.25; KINASE; Kinase, protein; Protein kinase, Ser/Thr (non-receptor); Protein kinase, TKL Q60700 26404 15|15 F3 mouse S584-p 40416401 KTRHRKAsAKGSCGD enzymatic activity, inhibited cell growth, induced 25802931 1 1 0 S584A T659A mutants have inhibited growth and increased kinase activity +PELI1 PELI1 Adaptor/scaffold; EC 6.3.2.-; EC 6.3.2.19; Ligase; UBIQUITIN LIGASE; Ubiquitin conjugating system; Ubiquitin ligase Q96FA3 57162 2p14 human S78-p 7388013 NKDQHSIsYTLSRAQ Pellino ubiquitination; enzymatic activity, induced 19264966 2 0 0 +IRF3 IRF3 DNA-binding; Transcription factor Q14653 3661 19q13.33 human T75-p 55458201 RDKPDLPtWKRNFRS IRF molecular association, regulation; protein conformation transcription, inhibited DNA(DISRUPTS) 27125670 1 0 0 +Camkk2 CAMKK2 Autophagy; EC 2.7.11.17; KINASE; Kinase, protein; Protein kinase, Other; Protein kinase, Ser/Thr (non-receptor) O88831 83506 12q16 rat T144-p 15425433 PRMPRRPtVESHHVS activity, induced; enzymatic activity, inhibited; enzymatic activity, induced signaling pathway regulation 28974582; 30660766; 32085894 3 3 5 autonomous activity of CAMKK2 reversible to the phosphorylation by PKA +DNMT1 DNMT1 Amino Acid Metabolism - cysteine and methionine; Cell development/differentiation; EC 2.1.1.37; METHYLTRANSFERASE; Methyltransferase; Methyltransferase, DNA; Transcription regulation P26358 1786 19p13.2 human K148-sm 12726304 SKSDGEAkPEPSPSP enzymatic activity, induced DNA(INDUCES) 19450230 1 0 0 +DTNB DTNB Calcium-binding; Motility/polarity/chemotaxis O60941 1838 2p23.3 human T11-p 27100600 ESGNKRKtMAEKRQL molecular association, regulation KIF1A(INDUCES) 22978324 1 1 0 +Ncoa3 SRC-3 ACETYLTRANSFERASE; Acetyltransferase; EC 2.3.1.48; Motility/polarity/chemotaxis; Nuclear receptor co-regulator; Transcription, coactivator/corepressor O09000 17979 2|2 H3 mouse S847-p 453084 PPYNRAVsLDSPVSV methylation; phosphorylation carcinogenesis, inhibited; cell growth, inhibited; cell differentiation, induced; transcription, inhibited; signaling pathway regulation 17043108; 20534466 11 48 5 inhibits insulin/IGF1 signaling; S847 phosphorylation antagonizes Src-3 methylation +Cebpb C/EBP-beta DNA-binding; Motility/polarity/chemotaxis; Transcription factor P21272 24253 3q42 rat T189-p 447878 SSSSPPGtPSPADAK transcription, altered; cell growth, altered DNA(INDUCES) 15314150; 16055922 33 11 14 +HCLS1 HS1 Adaptor/scaffold; Motility/polarity/chemotaxis P14317 3059 3q13.33 human Y378-p 451635 EPEPENDyEDVEEMD activity, induced; molecular association, regulation; intracellular localization apoptosis, altered; cell motility, induced; cell motility, altered; cytoskeletal reorganization; transcription, altered ARPC2(INDUCES); VAV1(INDUCES) 16782030; 18587398; 22679023; 25723543; 9104825 8 2 37 +PAK1 PAK1 EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, STE; Protein kinase, Ser/Thr (non-receptor) Q13153 5058 11q13.5-q14.1 human K29-ub 56714906 TMIGAGSkDAGTLNH protein degradation 27302166 1 0 0 +NPR1 ANPA EC 4.6.1.2; Guanylyl cyclase; KINASE; Kinase, protein; Lyase; Membrane protein, integral; Nucleotide Metabolism - purine; Protein kinase, RGC; Protein kinase, dual-specificity (receptor); Receptor, misc. P16066 4881 1q21.3 human S542-p 448229 GRGSNYGsLLTTEGQ activity, induced; enzymatic activity, induced 28416574; 9528788 3 2 3 +Map1lc3a LC3A Autophagy; Microtubule-binding; Ubiquitin-like modifier; Vesicle Q91VR7 66734 2|2 H1 mouse S12-p 15116600 RPFKQRRsFADRCKE intracellular localization autophagy, altered 20713600 2 1 0 +BACH2 BACH2 DNA-binding; Transcription factor Q9BYV9 60468 6q15 human K202-sm 2798314 AAIPVAEkEEALLPE intracellular localization 18201693 2 0 0 mobility of nuclear domains +MAP3K11 MLK3 EC 2.7.11.25; KINASE; Kinase, protein; Protein kinase, Ser/Thr (non-receptor); Protein kinase, TKL Q16584 4296 11q13.1 human T477-p 36324901 HVRRRRGtFKRSKLR protein degradation; molecular association, regulation; ubiquitination; intracellular localization carcinogenesis, inhibited; apoptosis, inhibited 14-3-3 zeta(INDUCES) 25204656; 33875576 2 0 0 +RUBCNL RUBCNL Q9H714 80183 13q14.13 human K573-ac 1875445902 EDLVRIKkGLLAPLL zf-RING_9 molecular association, regulation autophagy, induced VPS39(INDUCES); VPS41(INDUCES); STX17(INDUCES) 30704899 1 1 0 required for autophagosome maturation and cellular lipid metabolism +HSF1 HSF1 DNA-binding; Transcription factor Q00613 3297 8q24.3 human S368-p 469242 PPSPPPTsTPEKCLS Vert_HS_TF transcription, inhibited 25963659 2 5 7 under non-stressed conditions, upon heat shock S to A mutant showed 60% higher luciferase activity +SMAD2 SMAD2 DNA-binding; Transcription factor Q15796 4087 18q21.1 human K54-ac 1876755703 SLVKKLKkTGRLDEL MH1 intracellular localization; phosphorylation transcription, induced 32535965 1 0 0 +LILRB2 LILRB2 Membrane protein, integral; Receptor, misc. Q8N423 10288 19q13.42 human Y561-p 2091907 EAPQDVTyAQLHSLT molecular association, regulation CSK(INDUCES); SHP-1(INDUCES) 11907092; 15474475 2 0 1 Mutation of Y533 prevented binding in vivo. +Atg3 ATG3 Autophagy; EC 6.3.2.-; Ubiquitin conjugating system Q9CPX6 67841 16|16 B5 mouse Y203-p 62940500 QTRTYDLyITYDKYY Autophagy_act_C protein degradation; molecular association, regulation; ubiquitination cell growth, induced BAG3(INDUCES) 28103122 1 1 0 mitotic catastrophe +Sqstm1 SQSTM1 Autophagy; Nuclear receptor co-regulator; Ubiquitin conjugating system Q64337 18412 11|11 B1.3 mouse S351-p 14580829 SSKEVDPsTGELQSL activity, induced; protein stabilization; molecular association, regulation; intracellular localization; phosphorylation; enzymatic activity, induced carcinogenesis, induced; carcinogenesis, inhibited; transcription, induced; transcription, altered; signaling pathway regulation; autophagy, induced; cell growth, induced; transcription, inhibited KEAP1(INDUCES) 24011591; 24492006; 25049227; 27215388; 27245349; 28055010; 28673615; 29225212; 31035006; 31362587; 33395605; 33875681; 34087234; 34531248; 35648750; 37306101 48 0 1 regulates the KEAP1-NRF2 pathway. +PPP1R12A MYPT1 Motility/polarity/chemotaxis; PHOSPHATASE; Protein phosphatase, regulatory subunit Q90623 396020 chicken T695-p 448587 ARQSRRStQGVTLTD enzymatic activity, inhibited 12030846 66 42 226 +WTAP WTAP Nucleolus; Spliceosome Q15007 9589 6q25.3 human T148-p 36131377 ELSAWKFtPDSQTGK Wtap cell differentiation, induced 33217317 1 1 0 +ALK ALK EC 2.7.10.1; KINASE; Kinase, protein; Membrane protein, integral; Oncoprotein; Protein kinase, TK; Protein kinase, tyrosine (receptor) Q9UM73 238 2p23.2-p23.1 human Y1096-p 450375 MTDYNPNyCFAGKTS molecular association, regulation IRS2(INDUCES) 30459283 2 6 97 +IRS2 IRS2 Adaptor/scaffold; Motility/polarity/chemotaxis Q9Y4H2 8660 13q34 human S679-p 472256 SDDYMPMsPASVSAP activity, inhibited 34731634 2 22 5 +NUMA1 NuMA-1 Cell cycle regulation; Motility/polarity/chemotaxis Q14980 4926 11q13.4 human K1766-sm 15511955 ISQRLPPkVESLESL cell cycle regulation; cytoskeletal reorganization 24309115 1 3 0 maintenance of mitotic spindle in mitosis +PARN PARN EC 3.1.13.4; Nucleolus; RNA-binding; Ribonuclease O95453 5073 16p13.12 human K566-ac 466276 TAPSTVGkRNLSPSQ enzymatic activity, inhibited 32457045 1 0 23 K566 regulates levels of adenylated hTR +RNF157 RNF157 UBIQUITIN LIGASE; Ubiquitin conjugating system; Ubiquitin ligase Q96PX1 114804 17q25.1 human S663-p 5202129 RRRLSSSsLEDSETR protein degradation; molecular association, regulation; ubiquitination CDH1(INDUCES) 28655764 1 2 3 +MAP3K8 Cot EC 2.7.11.25; KINASE; Kinase, protein; Oncoprotein; Protein kinase, STE; Protein kinase, Ser/Thr (non-receptor) P41279 1326 10p11.23 human S62-p 2868603 QNDERSKsLLLSGQE enzymatic activity, induced 16806191 2 2 0 +PSIP1 LEDGF Motility/polarity/chemotaxis; Transcription, coactivator/corepressor O75475 11168 9p22.3 human K75-sm 13875713 YGKPNKRkGFNEGLW PWWP protein degradation transcription, inhibited 20382164 1 1 0 +ZNF420 ZNF420 C2H2-type zinc finger protein; Transcription factor Q8TAQ5 147923 19q13.12 human S68-p 7669300 NTYETELsQWEMSDR molecular association, regulation p53(DISRUPTS) 19377469 1 0 0 in response to DNA damage, ZNF420 (Apak) dissociates from p53 and activates p53-mediated apoptosis +RELB RELB Transcription factor Q01201 5971 19q13.32 human S472-p 36392502 DFFSGTVsLPGLEPP RelB_transactiv molecular association, regulation cell motility, induced; transcription, induced IkB-alpha(DISRUPTS) 25267645 2 0 0 MMP3 transcription +SRC Src EC 2.7.10.2; KINASE; Kinase, protein; Oncoprotein; Protein kinase, TK; Protein kinase, tyrosine (non-receptor) P12931 6714 20q11.23 human S12-p 448230 KSKPKDAsQRRRSLE molecular association, regulation; enzymatic activity, induced PPP2R2C(INDUCES) 18069897 5 1 1 interferes with PPP2R2C abitity to inhibit JNK phosphorylation following exposure to UV; in cells treated with UV +ARHGAP8 ARHGAP8 GAP; GAP, Rac/Rho; Motility/polarity/chemotaxis P85298 23779 22q13.31 human S455-p 3635677 TKPTLPPsPLMAARR activity, induced; molecular association, regulation; protein conformation cell growth, induced LAMTOR3(INDUCES); MEK1(INDUCES) 28092672 1 5 3 LAMTOR3-mediated nuclear accumulation of phospho-ERK1/2 +ERBB2 HER2 EC 2.7.10.1; KINASE; Kinase, protein; Membrane protein, integral; Oncoprotein; Protein kinase, TK; Protein kinase, tyrosine (receptor) P04626 2064 17q12 human Y877-p 448694 LDIDETEyHADGGKV PK_Tyr_Ser-Thr protein conformation; enzymatic activity, induced carcinogenesis, induced; cell differentiation, induced; apoptosis, inhibited; cell growth, altered 17030621; 19704002; 23376850; 34107301; 37324940; 37331014 25 14 111 +Dlc1 DLC1 GAP; GAP, Rac/Rho; Tumor suppressor Q9R0Z9 50768 8 A4|8 23.05 cM mouse Y702-p 1869008601 SAEDNVNyEGQSAYD RhoGAP enzymatic activity, inhibited carcinogenesis, induced; cell growth, induced; apoptosis, inhibited 31308216 1 1 0 Rho-GAP activity +ESR1 ER-alpha DNA-binding; Nuclear receptor; Transcription factor P03372 2099 6q25.1-q25.2 human S294-p 451560 RAANLWPsPLMIKRS activity, induced; protein degradation; molecular association, regulation; ubiquitination; protein conformation cell cycle regulation; transcription, induced; transcription, inhibited; transcription, altered SKP2(INDUCES); UBE3A(INDUCES); PIN1(INDUCES) DNA(DISRUPTS) 20043841; 22431515; 23390529; 23770852; 27765908; 34711683 11 4 0 +HSPB8 HSPB8 Heat shock protein Q9UJY1 26353 12q24.23 human S57-p 2201401 DWALPRLsSAWPGTL protein degradation; protein conformation 18298377 1 5 0 in vitro; decreases oligomerization and chaperone-like activity of H11 +PTK2 FAK EC 2.7.10.2; KINASE; Kinase, protein; Protein kinase, TK; Protein kinase, tyrosine (non-receptor) Q05397 5747 8q24.3 human Y397-p 447887 SVSETDDyAEIIDEE activity, induced; protein degradation; molecular association, regulation; intracellular localization; enzymatic activity, induced; phosphorylation carcinogenesis, induced; apoptosis, altered; cell motility, induced; cell adhesion, induced; cell motility, inhibited; signaling pathway regulation; cell adhesion, inhibited; cell differentiation, altered; cell growth, induced; cell motility, altered; cell growth, altered; cell differentiation, inhibited; endocytosis, altered; carcinogenesis, inhibited; transcription, induced; transcription, altered; cell differentiation, induced; apoptosis, inhibited; cell adhesion, altered; cytoskeletal reorganization RASA1(INDUCES); Src(INDUCES); SRC-1(INDUCES); PIK3R2(DISRUPTS); Src(DISRUPTS); Vimentin(INDUCES); FAK(INDUCES); PIK3R1(INDUCES) 10821872; 11035755; 11331870; 11839732; 11857088; 12084011; 12408869; 12639965; 12659633; 15077193; 15371459; 15561106; 15707572; 15944157; 16652148; 17096371; 18032789; 18437915; 18676832; 19423701; 20129247; 20160475; 20180147; 20802513; 21768358; 21876001; 23264741; 24858039; 26068982; 26530902; 26710849; 28692661; 28759036; 32049010; 32205868; 32612176; 33532186; 33674746; 33715263; 33761359; 33952697; 33981002; 33999101; 34052254; 34226698; 34240802; 34335982; 34383763; 34619327; 34858503; 35124008; 35125823; 35131384; 35201437; 35257717; 35307378; 35471457; 35594862; 35773413; 35850179; 35962191; 36797281; 36804546; 37083591; 37443754; 8824286 371 31 474 in vitro and in vivo +C5AR1 C5aR GPCR, family 1; Membrane protein, integral; Membrane protein, multi-pass; Receptor, GPCR P21730 728 19q13.32 human S338-p 448820 ESKSFTRsTVDTMAQ molecular association, regulation; receptor desensitization, altered ARRB1(INDUCES); ARRB2(INDUCES) 10636859; 12464600; 17145764 4 0 1 induces translocation of beta-arrestin into the plasma membrane +IRF3 IRF3 DNA-binding; Transcription factor Q14653 3661 19q13.33 human Y292-p 1867930600 RLGHCHTyWAVSEEL IRF-3 activity, induced transcription, induced 30842273 1 1 0 IFN-beta expression +EGFR EGFR EC 2.7.10.1; KINASE; Kinase, protein; Membrane protein, integral; Oncoprotein; Protein kinase, TK; Protein kinase, tyrosine (receptor) P00533 1956 7p11.2 human S1071-p 448052 SFLQRYSsDPTGALT receptor desensitization, altered; receptor internalization, altered 1309762; 7505275 17 2 8 +FERMT1 kindlin-1 Cytoskeletal; Motility/polarity/chemotaxis Q9BQL6 55612 20p12.3 human S174-p 3210720 LESSPTAsGSSVSPG protein degradation cell cycle regulation; cell growth, induced; apoptosis, inhibited; cytoskeletal reorganization; cell adhesion, inhibited 35469017 1 3 0 +Agtr1 AT1 GPCR, family 1; Membrane protein, integral; Membrane protein, multi-pass; Receptor, GPCR P25095 24180 17p12 rat S338-p 452092 STKMSTLsYRPSDNM activity, induced; molecular association, regulation ARRB2(INDUCES) 16831865; 29146594 5 0 0 BRET +EGFR EGFR EC 2.7.10.1; KINASE; Kinase, protein; Membrane protein, integral; Oncoprotein; Protein kinase, TK; Protein kinase, tyrosine (receptor) P00533 1956 7p11.2 human Y869-p 448061 LGAEEKEyHAEGGKV PK_Tyr_Ser-Thr activity, induced; molecular association, regulation; enzymatic activity, induced cell cycle regulation; carcinogenesis, induced; carcinogenesis, inhibited; cell motility, induced; transcription, induced; signaling pathway regulation; apoptosis, inhibited; cell motility, altered; cell adhesion, altered; cell growth, altered PKCZ(INDUCES); PKCE(INDUCES); COX2(INDUCES) 11983694; 12842895; 15282306; 15592458; 16037379; 16849545; 16862179; 17561374; 19305428; 20407013; 21787862; 28102297; 33657368; 33706413; 34088769 97 20 171 +Notch1 Notch 1 Membrane protein, integral; Motility/polarity/chemotaxis; Oncoprotein; Receptor, misc.; Transcription factor Q01705 18128 2 A3|2 18.91 cM mouse K2050-ac 18899506 NKDMQNNkEETPLFL Ank_2 protein stabilization; ubiquitination 21499261 1 1 0 +TJP1 ZO1 Adaptor/scaffold; Motility/polarity/chemotaxis Q07157 7082 15q13.1 human T770-p 30306604 KNNHHLFtTTINLNS Guanylate_kin molecular association, regulation cell adhesion, inhibited occludin(DISRUPTS) 24338688 1 0 0 15(S)-HETE or 12(S)-HETE (high fat diet) -induced endothelial tight junction (TJ) disruption +CD19 CD19 Cell surface; Membrane protein, integral P15391 930 16p11.2 human Y531-p 447639 HEEDADSyENMDNPD molecular association, regulation LYN(INDUCES); PIK3CA(INDUCES); VAV1(INDUCES) 10933394 8 3 18 +PLCG1 PLCG1 Carbohydrate Metabolism - inositol phosphate; EC 3.1.4.11; Motility/polarity/chemotaxis; Phospholipase P08487 281987 cow Y509-p 464036 NHEWYPHyFVLTSSK enzymatic activity, induced cell motility, altered; cytoskeletal reorganization; cell growth, altered PLCG1(INDUCES) 17116690 3 0 8 PLCG1 with a nonfunctional domain is constitutively active. ELISA assay showed SH2N and SH2C bound to Y132 phospho-peptide. Binding was mediated by SH2N domain. sPH blocks binding of SH2 domain to target proteins. Y509F /506F did not affect binding to pY132 LAT, but Y509A/F510A did show sigification binding. Y509A/F510A mutation showed increased NF-AT transcription, as compared to wild-type. +PKM PKM Carbohydrate Metabolism - glycolysis and gluconeogenesis; Carbohydrate Metabolism - pyruvate; EC 2.7.1.40; KINASE; Kinase, other; Mitochondrial; Nucleotide Metabolism - purine P14618 5315 15q23 human Y390-p 450529 REAEAAIyHLQLFEE PK enzymatic activity, inhibited carcinogenesis, induced; cell growth, induced 23814019 2 12 129 +SLC3A2 SLC3A2 Membrane protein, integral; Transporter P08195 6520 11q12.3 human S527-p 6003505 LSLFRRLsDQRSKER cell adhesion, altered 19065266 1 0 0 enhances cell- cell interactions +AKT1S1 PRAS40 Apoptosis Q96B36 84335 19q13.33 human T246-p 470067 LPRPRLNtSDFQKLK PRAS activity, induced; molecular association, regulation; activity, inhibited; phosphorylation cell cycle regulation; carcinogenesis, induced; cell motility, induced; signaling pathway regulation; cell growth, induced; apoptosis, inhibited; autophagy, inhibited; translation, induced 14-3-3 beta(INDUCES); Raptor(DISRUPTS); 14-3-3 eta(INDUCES); 14-3-3 beta(DISRUPTS) 12524439; 17277771; 17386266; 18215133; 18372248; 21750219; 21914810; 26009991; 34523696; 34762647; 34948236; 35058442; 35279705 50 69 781 +CBX4 CBX4 EC 6.3.2.-; SUMO LIGASE; SUMO conjugating system; SUMO ligase; Transcription, coactivator/corepressor O00257 8535 17q25.3 human T437-p 7315202 ARSISTPtCLGGSPA protein degradation; molecular association, regulation; ubiquitination carcinogenesis, inhibited; cell motility, inhibited CHIP(INDUCES) 32111827 1 1 0 increases ubiquitylation at CBX4-K178, K280 +TP63 p63 DNA-binding; Transcription factor Q9H3D4 8626 3q28 human Y171-p 10359107 AIPSNTDyPGPHSFD P53 protein stabilization 19783996 1 0 0 +E2f7 E2F7 Cell cycle regulation; DNA-binding; Transcription factor Q6S7F2 52679 10 D1|10 57.74 cM mouse S411-p 3208641 ERLVRYGsFNTVHTS molecular association, regulation cell cycle regulation; apoptosis, inhibited; transcription, induced 14-3-3 zeta(INDUCES) 29363506 1 20 14 +USF2 USF2 DNA-binding; Transcription factor Q15853 7392 19q13.12 human T230-p 3801550 PKIDGTRtPRDERRR protein stabilization; molecular association, regulation; protein conformation cell motility, induced; transcription, induced DNA(INDUCES) 25238393 1 1 3 target gene transcription of HO-1, PAI-1, and FAS +L1cam NCAM-L1 Cell adhesion; Membrane protein, integral P11627 16728 X A7.3|X 37.43 cM mouse K1172-sm 31089525 DSEARPMkDETFGEY Bravo_FIGEY cell motility, induced 24118054 1 0 0 cathepsin E-mediated genertion of a sumoylated 30 kDa L1 fragment that induces Schwann cell migration and myelination +Nfatc2 NFAT1 DNA-binding; Transcription factor Q60591 18019 2 H3|2 88.91 cM mouse S176-p 447842 LSPASSGsSASFISD transcription, inhibited 11030334 0 1 0 +Map2k1 MEK1 EC 2.7.12.2; KINASE; Kinase, protein; Protein kinase, STE; Protein kinase, dual-specificity (non-receptor) Q01986 170851 8q24 rat S222-p 448513 LIDSMANsFVGTRSY Pkinase enzymatic activity, induced 8034665; 8157000 117 20 203 +OCLN occludin Cell adhesion; Membrane protein, integral; Membrane protein, multi-pass; Motility/polarity/chemotaxis Q16625 100506658 5q13.2 human S490-p 6094300 RLKQVKGsADYKSKK Occludin_ELL protein degradation; molecular association, regulation; ubiquitination; intracellular localization cell cycle regulation; endocytosis, altered; cell growth, induced; cytoskeletal reorganization ZO1(DISRUPTS); Hrs(INDUCES); ITCH(INDUCES); epsin 1(INDUCES); EPS15(INDUCES) 19125584; 19478092; 21757728; 22438576; 31073629; 31553086 11 1 0 alters ZO-1 distribution/ degradation of tight juction protein in a p75NTR-dependent manner +Kif7 KIF7 Microtubule-binding; Motor B7ZNG0 16576 7|7 D2 mouse S1337-p 4170004 RWEPRRTsPGMIDVR intracellular localization transcription, altered; signaling pathway regulation 25492966 1 5 0 1) Localization of Gli proteins to cilicary tip 2) Hedghog pathway activation 3) Gli-mediated transcriptional output +MET Met EC 2.7.10.1; KINASE; Kinase, protein; Membrane protein, integral; Oncoprotein; Protein kinase, TK; Protein kinase, tyrosine (receptor) P08581 4233 7q31.2 human Y1313-p 450189 EYCPDPLyEVMLKCW PK_Tyr_Ser-Thr activity, induced cell motility, induced; cell growth, induced; signaling pathway regulation 21777671; 24634221 6 1 4 signaling to induce lamellipodia formation and ROS generation in lung cells; Ras/MAPK signaling pathway +MORC2 MORC2 DNA-binding Q9Y6X9 22880 22q12.2 human S739-p 3217905 ATPSRKRsVAVSDEE intracellular localization; enzymatic activity, induced cell cycle regulation; carcinogenesis, induced; DNA repair, induced; cell growth, induced; chromatin organization, altered; signaling pathway regulation 23260667; 25888627 2 37 8 proliferation of gastric cancer cells; ATM-PAK1-MORC2 pathway +PRL prolactin Cytokine; Motility/polarity/chemotaxis; Secreted; Secreted, signal peptide P01240 sheep S181-p 17790903 TEPYPVWsGLPSLQT Hormone_1 activity, induced 15684343 9 0 0 improved thermoregulation and UCP1 function +HNRNPK hnRNP K RNA splicing; RNA-binding; Spliceosome P61978 3190 9q21.32 human R299-m1 8092824 PPPGRGGrGGSRARN molecular association, regulation; phosphorylation apoptosis, inhibited PKCD(DISRUPTS) 25104022 1 4 20 methylation of R296 and R299 suppress S302 phosphorylation, R296/R299 methylation reduces apoptosis in U2OS-K- 2RK cells after DNA damage +STIM1 STIM1 Calcium-binding; Endoplasmic reticulum; Membrane protein, integral Q13586 6786 11p15.4 human S521-p 468874 RDLTHSDsESSLHMS signaling pathway regulation 31381180 1 34 7 +SATB1 SATB1 DNA-binding; Transcription factor Q01826 6304 3p24.3 human S185-p 464645 DLPPEQWsHTTVRNA CUTL molecular association, regulation; acetylation transcription, inhibited HDAC1(INDUCES); PCAF(INDUCES) DNA(INDUCES) 16630892 2 0 0 Downregulates gene expression +Rcan1 RCAN1 Inhibitor Q6IN33 266766 11q11 rat S93-p 25687504 AQTLHIGsSHLAPPN Calcipressin enzymatic activity, inhibited neural plasticity 32084406 3 2 0 inhibits calcineurin activity further causing LTP +FHL1 FHL1 iso1 Cell development/differentiation Q13642-1 2273 Xq26.3 human Y272-p 1015543 VFHQEQVyCPDCAKK LIM intracellular localization cell growth, induced BCLAF1(INDUCES) 29434030 1 1 21 translocate to the nucleus +Met Met EC 2.7.10.1; KINASE; Kinase, protein; Membrane protein, integral; Oncoprotein; Protein kinase, TK; Protein kinase, tyrosine (receptor) P16056 17295 6 A2|6 7.83 cM mouse Y1363-p 448474 NVKCVAPyPSLLPSQ molecular association, regulation cell motility, altered; cytoskeletal reorganization GRB2(INDUCES); PIK3C2A(INDUCES); GAB1(INDUCES); SHC1(INDUCES) 10069803; 7708691 8 5 116 activates cell mobility +GRB2 GRB2 Adaptor/scaffold; Cell development/differentiation; Motility/polarity/chemotaxis P62993 2885 17q25.1 human Y7-p 478849 _MEAIAKyDFKATAD SH3_1 cell growth, altered 19273609 1 0 2 regulates cell proliferation +NPM1 NPM1 Nucleolus; Oncoprotein; RNA-binding; Translation P06748 4869 5q35.1 human S4-p 452023 ____MEDsMDMDMSP intracellular localization cell cycle regulation; cytoskeletal reorganization 15190079; 20352051; 30453269 6 30 1 +ATP2A1 ATP2A1 EC 3.6.3.8; Endoplasmic reticulum; Hydrolase; Membrane protein, integral; Membrane protein, multi-pass; Transporter; Transporter, ion channel O14983 487 16p11.2 human S186-p 4764562 ILTGESVsVIKHTEP E1-E2_ATPase molecular association, regulation; enzymatic activity, induced ATP2A1(INDUCES) 19628462 1 3 0 +Aatk Lmr1 EC 2.7.11.1; KINASE; Kinase, protein; Membrane protein, integral; Protein kinase, Ser/Thr (non-receptor); Protein kinase, TK; Protein kinase, tyrosine (receptor) Q80YE4 11302 11|11 E2 mouse S614-p 456515 PCPSRSPsPGTPMLP apoptosis, induced 16100393 1 0 0 +YBX1 YB-1 RNA processing; RNA splicing; RNA-binding; Transcription factor P67809 4904 1p34.2 human T89-p 36130583 EDVFVHQtAIKKNNP CSD activity, induced; molecular association, regulation; ubiquitination; intracellular localization carcinogenesis, induced; DNA repair, induced; cell growth, induced; transcription, induced; signaling pathway regulation DNA(INDUCES) 36475703; 37328464 2 2 0 induces the TOPK/YB1/eEF1A1 signal pathway +VIL1 Villin Actin-binding; Motility/polarity/chemotaxis P09327 7429 2q35 human Y81-p 454006 EQGAAAIyTTQMDDF Gelsolin molecular association, regulation; intracellular localization cytoskeletal reorganization ACTB(INDUCES) 12269817; 15342783 3 0 0 +CD4 CD4 Cell surface; Membrane protein, integral P01730 920 12p13.31 human S433-p 451188 RRQAERMsQIKRLLS Tcell_CD4_C protein degradation; receptor internalization, altered; intracellular localization 15494497; 1674746 3 0 3 +CREBBP CBP ACETYLTRANSFERASE; Acetyltransferase; DNA-binding; EC 2.3.1.48; Motility/polarity/chemotaxis; Nuclear receptor co-regulator; Transcription, coactivator/corepressor Q92793 1387 16p13.3 human K1595-ac 461371 KNNKKTNkNKSSISR HAT_KAT11 acetylation 28630323 1 6 255 autoacetylation of CBP K1596 (autoregulatory loop (AL) of CBP) has a negative regulatory effect on acetylation of H3K27 +CD6 CD6 Cell surface; Membrane protein, integral P30203 923 11q12.2 human S482-p 28095003 PEDSDSGsDSDYEHY phosphorylation signaling pathway regulation 23711376 1 0 0 ERK1/2 phosphorylation, MAPK pathway activation +GHSR GHSR GPCR, family 1; Membrane protein, integral; Membrane protein, multi-pass; Receptor, GPCR Q92847 2693 3q26.31 human S252-p 1877127904 GDAVVGAsLRDQNHK 7tm_1 molecular association, regulation ARRB2(INDUCES) 35605660 1 0 0 +TBXA2R TXA2-R GPCR, family 1; Membrane protein, integral; Membrane protein, multi-pass; Receptor, GPCR P21731 6915 19p13.3 human S145-p 469630 FSRPAVAsQRRAWAT 7tm_1 receptor desensitization, induced signaling pathway regulation 17466390 2 0 0 +CDC26 CDC26 Q8NHZ8 246184 9q32 human T7-p 10815632 _MLRRKPtRLELKLD ANAPC_CDC26 molecular association, regulation; ubiquitination APC4(DISRUPTS); CDC16(DISRUPTS) 25723520 1 0 7 Ubiquitination of PLK1; affects APC/C assembly +SLC7A11 SLC7A11 Membrane protein, integral; Membrane protein, multi-pass; Transporter; Transporter, SLC family Q9UPY5 23657 4q28.3 human S26-p 470841 NVNGRLPsLGNKEPP intracellular localization; activity, inhibited autophagy, inhibited 28648777; 33531365 3 28 9 +MRE11 MRE11A Cell cycle regulation; DNA repair, damage; DNA-binding; Deoxyribonuclease P49959 4361 11q21 human R574-me 2344814 NKGRGRGrGRRGGRG intracellular localization 15970667 1 0 0 localizes in nucleus and associates with nuclear bodies and sites of DNA damage +PRKN PARK2 EC 6.3.2.-; EC 6.3.2.19; Ligase; Translation; Translation regulation; UBIQUITIN LIGASE; Ubiquitin conjugating system; Ubiquitin ligase O60260 5071 6q26 human S108-p 17550101 SLTRVDLsSSVLPGD ubiquitination; intracellular localization; phosphorylation; enzymatic activity, induced cell cycle regulation; autophagy, induced; autophagy, inhibited 33827825; 35642724 2 2 1 +Tbx21 TBX21 DNA-binding; Transcription factor Q9JKD8 57765 11|11 D mouse K313-ub 27930806 NAEITQLkIDNNPFA T-box protein stabilization; molecular association, regulation; phosphorylation NFAT1(INDUCES) 23616576 1 1 0 crucial for T302 phosphorylation +FOS Fos DNA-binding; Motility/polarity/chemotaxis; Oncoprotein; Transcription factor P01100 2353 14q24.3 human Y30-p 473044 AGDSLSYyHSPADSF intracellular localization cell cycle regulation; cell growth, inhibited 17160021; 22105363 2 0 0 critical for association of Fos with endoplasmic reticulum membranes and phospholipid synthesis activation; inhibits phospholipid synthesis +Crk CRK Adaptor/scaffold; Motility/polarity/chemotaxis; Oncoprotein Q64010 12928 11 B5|11 45.92 cM mouse Y221-p 447951 GGPEPGPyAQPSVNT molecular association, regulation; enzymatic activity, inhibited Abl iso4(INDUCES); CBL(INDUCES); CRK(INDUCES) 11380621; 20697350; 7700361 25 14 1168 +Erbb2 HER2 EC 2.7.10.1; KINASE; Kinase, protein; Membrane protein, integral; Oncoprotein; Protein kinase, TK; Protein kinase, tyrosine (receptor) P06494 24337 10q31 rat Y1224-p 448675 PAFDNLYyWDQNSSE molecular association, regulation apoptosis, altered SHC1(DISRUPTS); SHC1(INDUCES) 11500516; 19826412 36 1 8 inhibits apoptosis; This site can mediate transforming signals. +Adam17 TACE EC 3.4.24.86; Membrane protein, integral; Motility/polarity/chemotaxis; Protease Q9Z1K9 57027 6q16 rat T735-p 449804 KPFPAPQtPGRLQAL enzymatic activity, induced signaling pathway regulation 21411748 18 15 6 required for NGF-induced p75NTR cleavage; important for cell survival +Mef2d MEF2D DNA-binding; Transcription factor Q63943 17261 3 F1|3 38.78 cM mouse S190-p 2246701 QPALQRNsVSPGLPQ protein stabilization; molecular association, regulation; protein conformation; activity, inhibited cell differentiation, altered; transcription, inhibited HDAC9(INDUCES); ASH2L(DISRUPTS); HDAC4(INDUCES) 18299387; 23723416 2 2 0 +SHB SHB Adaptor/scaffold Q15464 6461 9p13.1 human Y297-p 458102 QHKGIQLyDTPYEPE molecular association, regulation cell motility, induced; signaling pathway regulation NCK1(INDUCES); NCK2(INDUCES) 32060095 1 9 103 regulates EphB2 signaling +YAP1 YAP1 Oncoprotein; Transcription, coactivator/corepressor P46937 10413 11q22.1 human K254-ub 964556210 YYINHKNkTTSWLDP WW protein degradation; ubiquitination cell motility, inhibited 33939216 1 1 0 TNBC cell migration and invasion +RBM15 RBM15 Oncoprotein; RNA-binding; Spliceosome Q96T37 64783 1p13.3 human R578-m2 35483228 LLYRDRDrDLYPDSD protein degradation; ubiquitination cell differentiation, inhibited; RNA splicing, inhibited 26575292 1 1 0 megakaryocyte (MK) and B cell differentiation, methylation controls the RBM15 dosage thereby controling alternative RNA splicing +PLEKHG2 PLEKHG2 GEF; GEF, misc.; Tumor suppressor Q9H7P9 64857 19q13.2 human T680-p 31836500 AIPSVPNtPSLSSTP transcription, induced; cytoskeletal reorganization 24554703 1 0 0 neurite outgrowth +Cdkn1a p21Cip1 Cell cycle regulation; Inhibitor P39689 12575 17 A3.3|17 15.12 cM mouse Y76-p 26400605 SLGLPKVyLSPGSRS carcinogenesis, induced; cell growth, induced 23007395 1 0 0 +UPF1 RENT1 C2H2-type zinc finger protein; EC 3.6.1.-; EC 3.6.4.-; Hydrolase; RNA-binding Q92900 5976 19p13.11 human T151-p 50788283 FCNGRGNtSGSHIVN UPF1_Zn_bind molecular association, regulation; protein conformation; enzymatic activity, induced RNA stability, inhibited ELF4(DISRUPTS); UPF2(DISRUPTS); UPF3B(DISRUPTS); CTIF(DISRUPTS) 35675814 1 2 0 +CTTN Cortactin Actin-binding; Cytoskeletal; Motility/polarity/chemotaxis Q14247 2017 11q13.3 human Y421-p 447702 RLPSSPVyEDAASFK molecular association, regulation carcinogenesis, induced; cell motility, induced; cell adhesion, altered; cytoskeletal reorganization N-WASP(INDUCES) 15056655; 21696810; 24188565; 25682866; 29133485; 32005974; 34088320; 36258022; 9748248 47 62 745 +Cbx7 CBX7 Transcription regulation Q8VDS3 52609 15 E1|15 37.85 cM mouse T119-p 29669800 TNGPPPWtPTLPSSE CBX7_C molecular association, regulation transcription, inhibited PCGF2(INDUCES); RNF2(INDUCES); BMI1(INDUCES) 24194518 1 1 0 enhances p16 repression +SP1 SP1 C2H2-type zinc finger protein; DNA-binding; Transcription factor P08047 6667 12q13.13 human S491-gl 4283200 LAPMQGVsLGQTSSS molecular association, regulation transcription, induced SP1(DISRUPTS) 9343410 3 1 0 +HIF1A HIF1A Autophagy; DNA-binding; Transcription factor Q16665 3091 14q23.2 human T455-p 31887953 LAMSPLPtAETPKPL protein stabilization; molecular association, regulation; ubiquitination carcinogenesis, induced; cell growth, induced; transcription, induced EGLN1(DISRUPTS) 34211090 3 4 0 inhibits ubiquitination +UBA52-RPS27A-UBB-UBC ubiquitin Ubiquitin-like modifier P62988 2p16 human S57-p 448541 LEDGRTLsDYNIQKE ubiquitin enzymatic activity, induced 27425610 1 30 0 modest effects on UBE3C ligase activity +NFYA NFYA DNA-binding; Transcription factor P23511 4800 6p21.1 human S320-p 23254175 GEGGRFFsPKEKDSP molecular association, regulation; intracellular localization cell cycle regulation; transcription, induced DNA(DISRUPTS) 30589568 1 2 1 +SH2B1 SH2-B-beta Adaptor/scaffold Q9NRF2 25970 16p11.2 human S161-p 21336502 SLRSVGRsVRGSVRG intracellular localization cell motility, induced; cell adhesion, altered 21878491 2 0 2 regulates focal adhesion size and number +Ndel1 NDEL1 Microtubule-binding; Protease Q9ERR1 83431 11|11 B3 mouse S251-p 474509 LTPSARIsALNIVGD NUDE_C intracellular localization cytoskeletal reorganization 17060449; 25698733 2 1 0 impaired transport of DISC1and PAFAH1B1 to neurite tips, inhibited microtuble elongation; important for centrosome separation during mitosis +EPOR EPOR Membrane protein, integral; Receptor, cytokine P19235 2057 19p13.2 human Y368-p 449883 SEHAQDTyLVLDKWL activity, induced; molecular association, regulation; phosphorylation cell cycle regulation; apoptosis, inhibited; transcription, altered; signaling pathway regulation; cell growth, altered STAT5A(INDUCES); SOCS3(INDUCES) 10455108; 11290583; 12027890; 12506011; 14662339; 15878737; 19187767; 8657137 17 0 0 promotes STAT5 and JAK2 phosphorylation; activates Stat5 +RIGI RIGI EC 3.6.4.13; Hydrolase O95786 23586 9p21.1 human S8-p 12613701 MTTEQRRsLQAFQDY CARD_2 molecular association, regulation; ubiquitination; enzymatic activity, inhibited; intracellular localization; activity, inhibited transcription, induced; transcription, inhibited TRIM25(DISRUPTS); MAVS(DISRUPTS) RNA(INDUCES) 20406818; 22114345; 23264040; 23499489; 24371060; 28250012; 34935440; 36113429 9 6 0 +NDE1 NUDE1 iso1 Cell cycle regulation; Cytoskeletal; Microtubule-binding Q9NXR1-1 54820 16p13.11 human T191-p 20722719 QKQEKPRtPMPSSVE NUDE_C protein degradation; molecular association, regulation; intracellular localization FBXW7(INDUCES); ZNF365(DISRUPTS) 16682949; 26206584 2 4 0 colocalization at centrosome, regulation of ciliary length +BRAF BRAF EC 2.7.11.1; KINASE; Kinase, protein; Oncoprotein; Protein kinase, Ser/Thr (non-receptor); Protein kinase, TKL P15056 673 7q34 human S614-p 14159399 SHQFEQLsGSILWMA PK_Tyr_Ser-Thr molecular association, regulation; enzymatic activity, inhibited MEK1(DISRUPTS) 27345148 2 2 0 +MST1R Ron EC 2.7.10.1; KINASE; Kinase, protein; Membrane protein, integral; Protein kinase, TK; Protein kinase, tyrosine (receptor) Q04912 4486 3p21.31 human Y1198-p 456482 QVARGMEyLAEQKFV PK_Tyr_Ser-Thr enzymatic activity, induced transcription, induced 24739671 2 0 0 relieves inhibition on Ron activation imposed by the JM-C region +ETV4 ETV4 DNA-binding P43268 2118 17q21.31 human K96-sm 3144816 HSPTTRIkKEPQSPR ETS_PEA3_N transcription, inhibited 17585876 4 1 0 +HIPK2 HIPK2 EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, CMGC; Protein kinase, Ser/Thr (non-receptor) Q9H2X6 28996 7q34 human K32-sm 1727700 FCSVKKLkIEPSSNW protein degradation; molecular association, regulation; intracellular localization; phosphorylation; enzymatic activity, induced transcription, induced; transcription, inhibited TLE1(DISRUPTS) 15766567; 15896780; 17018294 3 1 0 K32A (aka K25A) mutant increases phosphorylation of CBX4 +L1CAM NCAM-L1 Cell adhesion; Membrane protein, integral P32004 3897 Xq28 human S1248-p 472277 NDSSGATsPINPAVA molecular association, regulation cytoskeletal reorganization; cell adhesion, inhibited ANK3(INDUCES) 17151951; 21080252; 23431142; 29109170 5 12 0 L1 sensitivity to ethanol; S1248 phosphorylation is necessary for ethanol inhibition of adhesion. +CTNNB1 CTNNB1 Actin-binding; Cell adhesion; Motility/polarity/chemotaxis; Nuclear receptor co-regulator; Oncoprotein; Transcription factor P35222 1499 3p22.1 human S605-p 3545003 LFVQLLYsPIENIQR Arm molecular association, regulation; protein stabilization; intracellular localization; protein conformation cell growth, induced; transcription, induced PIN1(INDUCES) 25961922; 26740630 3 0 0 nuclear retention +Adcy2 ADCY2 Adenylyl cyclase; EC 4.6.1.1; Lyase; Membrane protein, integral; Membrane protein, multi-pass; Nucleotide Metabolism - purine; Transporter; Transporter, aquaporin family P26769 81636 1p11 rat S543-p 25795202 NRTLRTKsQKKRFEE Adcy_cons_dom activity, induced 22906005 1 1 0 cAMP release +Runx2 AML3 DNA-binding; Transcription factor Q08775 12393 17 B3|17 21.33 cM mouse S326-p 460575 KLDDSKPsLFSDRLS activity, induced transcription, induced 16421932 1 0 0 +FUS hnRNP P2 DNA-binding; Nuclear receptor co-regulator; Oncoprotein; RNA splicing; RNA-binding; SUMO LIGASE P35637 2521 16p11.2 human S84-p 3306336 STGGYGSsQSSQSSY molecular association, regulation 28942918 5 1 0 strongly reduced the effects of DNA-PK treatment on both hydrogel binding and droplet formation +Pxn PXN Adaptor/scaffold; Cell adhesion; Cytoskeletal; Motility/polarity/chemotaxis Q8VI36 19303 5 F|5 56.1 cM mouse Y31-p 448785 FLSEEPPySYPTGNH activity, induced; molecular association, regulation; phosphorylation apoptosis, altered; apoptosis, inhibited; cell adhesion, induced; cell motility, altered; cytoskeletal reorganization; cell adhesion, altered RASA1(INDUCES); Vinculin(INDUCES) 12446743; 15107421; 15138291; 20308429; 30604146 49 8 64 +CCR5 CCR5 GPCR, family 1; Membrane protein, integral; Membrane protein, multi-pass; Motility/polarity/chemotaxis; Receptor, GPCR; Receptor, cytokine P51681 1234 3p21.31 human S342-p 449902 ASSVYTRsTGEQEIS molecular association, regulation; receptor desensitization, altered; receptor internalization, altered ARRB1(INDUCES); ARRB2(INDUCES) 10085131; 11782464; 12065593 3 0 0 +BAIAP2L1 IRTKS Adaptor/scaffold; Cytoskeletal Q9UHR4 55971 7q21.3-q22.1 human Y293-p 472861 PAPSGRAyTSPLIDM cell motility, induced 21840312 1 0 21 +SRSF1 SF2 RNA splicing; RNA-binding; Spliceosome Q07955 6426 17q22 human S119-p 27106000 YGPPSRRsENRVVVS molecular association, regulation; activity, inhibited RNA splicing, inhibited RNA(INDUCES) 22393468 1 3 0 +USF1 USF1 DNA-binding; Transcription factor P22415 7391 1q23.3 human S309-p 40515061 EVVIKNDsN______ molecular association, regulation transcription, inhibited DNA(DISRUPTS) 36534975 1 5 0 +CDCA8 Borealin Cell cycle regulation; Nucleolus Q53HL2 55143 1p34.3 human T169-p 4203202 KRSSRANtVTPAVGR Borealin cell cycle regulation; cytoskeletal reorganization 18243099 2 1 0 chromosome alignment in mitosis +EIF4G1 eIF4G RNA-binding; Translation; Translation initiation Q04637 1981 3q27.1 human S1185-p 482920 RTPATKRsFSKEVEE molecular association, regulation; enzymatic activity, induced signaling pathway regulation Mnk1(INDUCES) 21576361 3 51 136 PKC-Ras-Erk pathway +Slc1a2 GLT1 Membrane protein, integral; Membrane protein, multi-pass; Transporter; Transporter, SLC family P31596 29482 3q32 rat K558-ub 4667701 VTLAANGkSADCSVE receptor internalization, induced; protein degradation 18805448 1 1 0 +ARRB2 ARRB2 Adaptor/scaffold P32121 409 17p13.2 human Y64-p 1883582900 TLTCAFRyGREDLDV Arrestin_N activity, induced; molecular association, regulation; protein conformation carcinogenesis, induced RKHD4(INDUCES); IGF1R(INDUCES) 37521868 1 0 0 +RUNX1 AML1 DNA-binding; Oncoprotein; Transcription factor Q01196 861 21q22.12 human T273-p 454403 SPSVHPAtPISPGRA molecular association, regulation; phosphorylation CBFB(INDUCES) 18695000 6 1 8 promotes AML1 and p300 phosphorylation +Sorbs1 SORBS1 iso5 Cell adhesion; Cytoskeletal; Motility/polarity/chemotaxis Q62417-5 20411 19 C3|19 34.25 cM mouse Y326-p 460519 RAEPKSIyEYQPGKS cell motility, altered 19891780 1 6 250 mutation of this site inhibits cell spreading +TRPV4 TRPV4 Channel, cation; Membrane protein, integral; Membrane protein, multi-pass Q9HBA0 59341 12q24.11 human T175-p 10272405 GLLPFLLtHKKRLTD activity, induced 19661060 1 0 0 +SLC1A2 GLT1 Membrane protein, integral; Membrane protein, multi-pass; Transporter; Transporter, SLC family P43004 6506 11p13 human K571-sm 12004400 SVEEEPWkREK____ molecular association, regulation; intracellular localization PML(INDUCES) 17823119 1 0 0 +Slc18a3 SLC18A3 Membrane protein, integral; Membrane protein, multi-pass; Transporter; Transporter, SLC family Q62666 60422 16p16 rat S480-p 450965 GLLTRSRsERDVLLD intracellular localization 10748073; 10769030 2 2 2 S480 phosphorylation increases the targeting of VAChT to large dense core vesicles. +AKAP8 AKAP8 Adaptor/scaffold; Cell cycle regulation; Mitochondrial; RNA-binding O43823 10270 19p13.12 human Y152-p 7366805 PYRPSYSyDYEFDLG molecular association, regulation 25770215 2 0 0 Phenylalanine mutants inhibited dissociation from nuclear structures; structural chromatin changes +FOXA2 FOXA2 DNA-binding; Transcription factor Q9Y261 3170 20p11.21 human K259-ac 27583504 QKRFKCEkQLALKEA protein stabilization; intracellular localization transcription, induced 23416070; 24875183 2 2 0 +Usp20 USP20 DEUBIQUITINASE; EC 3.4.19.12; Protease; Ubiquitin conjugating system; Ubiquitin-specific protease Q8C6M1 74270 2|2 B mouse S132-p 469013 AVADEGEsESEDDDL protein stabilization; molecular association, regulation; ubiquitination signaling pathway regulation AMFR(INDUCES) 33177714 2 53 2 inhibits ubiquitination of HMGCR thus stabilizing it, regulates the mTORC1?USP20?HMGCR pathway +G3BP2 G3BP-2 Adaptor/scaffold; Motility/polarity/chemotaxis; RNA-binding Q9UN86 9908 4q21.1 human T226-p 3072179 EELEEKStTPPPAEP ubiquitination carcinogenesis, induced; apoptosis, inhibited 35589951 1 10 0 induces p53 ubiquitination and degradation +PLK1 PLK1 EC 2.7.11.21; KINASE; Kinase, protein; Protein kinase, Other; Protein kinase, Ser/Thr (non-receptor) P53350 5347 16p12.2 human Y425-p 62370600 SDKYGLGyQLCDNSV POLO_box protein stabilization; molecular association, regulation cell cycle regulation AurA(INDUCES) 27899378 1 1 0 Y425 phosphorylation inhibits ubiquitination and degradation +Ppp2ca PPP2CA EC 3.1.3.16; Motility/polarity/chemotaxis; PHOSPHATASE; Protein phosphatase, Ser/Thr (non-receptor) P63330 19052 11|11 B1.3 mouse L309-me 3627520 RRTPDYFl_______ enzymatic activity, inhibited cytoskeletal reorganization; cell motility, inhibited 22729898 10 0 0 astrocyte migration (motility) inhibited; AB accumulation ; activation of P38 MAPK abolishes astrocyte migration; PP2A activity inhibited +TFAM TFAM DNA-binding; Transcription regulation Q00059 7019 10q21.1 human S55-p 18016712 SCPKKPVsSYLRFSK HMG_box protein degradation; intracellular localization transcription, inhibited DNA(DISRUPTS) 23201127 1 2 0 localized to mitochondria, Lon-mediated degradation +HSP90AA1 HSP90A Chaperone; Heat shock protein P07900 3320 14q32.31 human T725-p 3180216 PLEGDDDtSRMEEVD protein stabilization; molecular association, regulation carcinogenesis, induced; cell growth, induced HOPX(INDUCES); CHIP(DISRUPTS) 22824801 1 1 0 cell proliferation increased +CEP55 CEP55 Cancer Testis Antigen (CTA); Cell cycle regulation Q53EZ4 55165 10q23.33 human S425-p 457628 NREKVAAsPKSPTAA activity, induced; molecular association, regulation cell cycle regulation PLK1(INDUCES) 16198290 1 23 8 +FLT1 VEGFR1 EC 2.7.10.1; KINASE; Kinase, protein; Membrane protein, integral; Protein kinase, TK; Protein kinase, tyrosine (receptor) P17948 2321 13q12.3 human Y1169-p 448208 VQQDGKDyIPINAIL molecular association, regulation PLCG1(INDUCES) 9299537 1 0 6 +Fyn Fyn EC 2.7.10.2; KINASE; Kinase, protein; Oncoprotein; Protein kinase, TK; Protein kinase, tyrosine (non-receptor) P39688 14360 10 B1|10 20.51 cM mouse Y531-p 447883 FTATEPQyQPGENL_ enzymatic activity, inhibited endocytosis, induced; signaling pathway regulation 16339530; 35500650 19 15 1040 induces JNK signaling +JAK3 JAK3 EC 2.7.10.2; KINASE; Kinase, protein; Protein kinase, TK; Protein kinase, tyrosine (non-receptor) P52333 3718 19p13.11 human Y841-p 1881548602 GSVELCRyDPLGDNT molecular association, regulation; protein conformation; enzymatic activity, induced Other(DISRUPTS) 37109511 2 0 0 +KCNQ1 Kv7.1 Channel, potassium; Membrane protein, integral; Membrane protein, multi-pass P51787 3784 11p15.5-p15.4 human S577-p 456165 PSLFISVsEKSKDRG KCNQ_channel activity, induced 12879210 1 0 0 +BCL3 Bcl-3 Apoptosis; Nuclear receptor co-regulator; Oncoprotein; Transcription regulation P20749 602 19q13.32 human S406-p 3627522 PSSSPSQsPPRDPPG protein degradation; molecular association, regulation; ubiquitination transcription, altered; cell growth, altered HDAC6(INDUCES); HDAC3(INDUCES); HDAC1(INDUCES) 15469820 1 0 0 +Pik3r1 PIK3R1 KINASE; Kinase, lipid; Motility/polarity/chemotaxis P26450 18708 13 D1|13 53.92 cM mouse S361-p 20831300 TFLVRDAsTKMHGDY SH2 molecular association, regulation signaling pathway regulation 21825134 1 1 0 impairs PI3K pathway activation; inhibits binding to to phospho-Tyr peptides +RELA NFkB-p65 DNA-binding; Nuclear receptor co-regulator; Transcription factor Q04206 5970 11q13.1 human S281-p 456219 RPSDRELsEPMEFQY RHD_dimer protein degradation; molecular association, regulation; ubiquitination; intracellular localization transcription, induced; transcription, altered FBXW2(INDUCES) Other(INDUCES); DNA(INDUCES) 17991436; 18025230; 23100252; 34465889; 35164343 7 0 0 induces binding to Globospiramine and roscovitine +JUN Jun Oncoprotein; Transcription factor P05412 3725 1p32.1 human K254-sm 3289001 MESQERIkAERKRMR bZIP_1 intracellular localization transcription, inhibited 16055710 2 0 0 intranuclear distribution +Sik2 QIK EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, CAMK; Protein kinase, Ser/Thr (non-receptor) Q3LRT3 315649 8q23 rat S586-p 3212040 FREGRRAsDTPLTQG apoptosis, altered 21220102 4 35 17 overexpression of S587A increases cell death +MALT1 MALT1 Adaptor/scaffold; Apoptosis; EC 3.4.22.-; Ligase; Nuclear export; Protease; UBIQUITIN LIGASE; Ubiquitin conjugating system Q9UDY8 10892 18q21.32 human S816-p 1870751200 DEIPFSFsDRLRISE carcinogenesis, induced; cell growth, induced; transcription, induced; signaling pathway regulation 31644910 0 1 0 activates transcription of NF-kB +EZH2 EZH2 EC 2.1.1.43; METHYLTRANSFERASE; Methyltransferase; Methyltransferase, protein lysine Q15910 2146 7q36.1 human T261-p 63280110 GALPPECtPNIDGPN protein degradation cell motility, inhibited; transcription, inhibited 28242758 1 0 0 +LAT LAT Adaptor/scaffold; Membrane protein, integral O43561 27040 16p11.2 human K52-ub 31914109 YPRGIQFkRPHTVAP LAT signaling pathway regulation 23514740 2 1 0 TCR signaling +AGTR1 AT1 GPCR, family 1; Membrane protein, integral; Membrane protein, multi-pass; Receptor, GPCR P30556 185 3q24 human T336-p 467237 NLSTKMStLSYRPSD activity, induced; molecular association, regulation; intracellular localization; receptor internalization, altered ARRB1(INDUCES); ARRB2(INDUCES) 11579203; 15177932 3 0 0 +ITGB5 ITGB5 Cell adhesion; Membrane protein, integral; Motility/polarity/chemotaxis P18084 3693 3q21.2 human S759-p 14694704 REFAKFQsERSRARY Integrin_b_cyt cell motility, altered 20507994 1 0 0 +Lepr LEPR Membrane protein, integral; Receptor, cytokine P48356 16847 4 C6|4 46.96 cM mouse Y1077-p 451292 HREKSVCyLGVTSVN activity, induced; molecular association, regulation; phosphorylation transcription, altered SOCS3(INDUCES) 11108838; 15634336; 20059770 7 0 0 attenuation of STAT3 phosphorylation +NFE2L2 NRF2 DNA-binding; Transcription factor Q16236 4780 2q31.2 human K536-ac 7106310 LDHLKDEkEKLLKEK bZIP_Maf molecular association, regulation transcription, induced DNA(INDUCES) 19273602 1 1 0 +RAPGEF1 RAPGEF1 GEF; GEF, Ras; Motility/polarity/chemotaxis Q13905 2889 9q34.13 human Y554-p 1870440700 KNKHMLAyMQLLEDY molecular association, regulation; enzymatic activity, induced CDC25A(INDUCES) 32873726 1 0 0 induces Rap1, LFA1 and IL3 activation +H2AX H2AX DNA repair, damage; DNA-binding; Helicase P16104 3014 11q23.3 human S16-p 33703202 KARAKAKsRSSRAGL Histone protein stabilization; ubiquitination carcinogenesis, inhibited; cell growth, inhibited; transcription, induced; cell motility, inhibited 21224359; 33574926 2 0 0 +PLAG1 PLAG1 C2H2-type zinc finger protein; DNA-binding; Oncoprotein; Transcription factor Q6DJT9 5324 8q12.1 human K244-sm 3568000 NQELLKVkTEPVDFL intracellular localization cell growth, induced; transcription, inhibited 15208321; 16207715 2 0 0 +FCGR2A FCGR2A Cell surface; Membrane protein, integral; Receptor, misc. P12318 2212 1q23.3 human Y240-p 2906102 AAVVALIyCRKKRIS TM receptor internalization, altered 15075346 1 0 0 +CDK11B CDK11B Apoptosis; Cell cycle regulation; EC 2.7.11.22; KINASE; Kinase, protein; Motility/polarity/chemotaxis; Protein kinase, CMGC; Protein kinase, Ser/Thr (non-receptor) P21127 984 1p36.33 human S752-p 468448 QRVKRGTsPRPPEGG molecular association, regulation RNA splicing, induced CDK11B(INDUCES) 23178491 1 50 8 promotes pre-mRNA splicing +TBC1D7 TBC1D7 GAP; GAP, Rab Q9P0N9 51256 6p24.1 human S124-p 15415675 GKLPRSPsFPLEPDD protein stabilization; molecular association, regulation signaling pathway regulation 14-3-3 zeta(INDUCES) 30143532 1 1 1 Binding of 14-3-3 to S124 phosphorylated TBC1D7 prevents binding of Beta-TrCP2 consequently ubiquitination of TBC1D7. +CTTN Cortactin Actin-binding; Cytoskeletal; Motility/polarity/chemotaxis Q14247 2017 11q13.3 human K319-ac 482877 VQKDRMDkNASTFED HS1_rep molecular association, regulation; intracellular localization cell motility, inhibited ACTB(DISRUPTS) 17643370 1 1 0 Acetylation prevents localization to membrane ruf?es. +AKAP1 AKAP1 Adaptor/scaffold; Membrane protein, integral; Mitochondrial; RNA-binding Q92667 8165 17q22 human S159-p 465541 PKGVLFSsKSAEVCK molecular association, regulation PPP1CA(DISRUPTS) 16669629 1 0 2 +Csf2rb CSF2RB Membrane protein, integral; Receptor, cytokine P26955 12983 15 E1|15 37.36 cM mouse S603-p 448463 LGPPQSHsLPDLPDQ molecular association, regulation cell growth, altered 14-3-3 zeta(INDUCES); PIK3R1(INDUCES) 16437163 6 1 0 Phosphorylation of Y595 and S603 are exclusive. S603 phosphorylation induces binding to 14-3-3 and prevents binding to Shc. +NOS3 eNOS Amino Acid Metabolism - arginine and proline; EC 1.14.13.39; Oxidoreductase P29473 287024 cow S1181-p 467802 RIRTQSFsLQERHLR molecular association, regulation; enzymatic activity, induced HSP90A(INDUCES) 28654706 11 8 1 enhanced eNOS affinity to all eNOS cofactors, including L-arginine, NADPH, CaM/ Ca2+and BH4. +Tp53 p53 Activator; DNA-binding; Motility/polarity/chemotaxis; Nuclear receptor co-regulator; Transcription factor; Tumor suppressor P02340 22059 11 B3|11 42.83 cM mouse K379-ub 464658 QSTSRHKkTMVKKVG transcription, altered 15964796 10 0 0 p53K6R (K378/383/369/379/367/370/R) mutant is still ubiquitinated and shows normal stability of p53 before and after DNA damage +PAK3 PAK3 EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, STE; Protein kinase, Ser/Thr (non-receptor) O75914 5063 Xq23 human S50-p 448125 NKKARLRsIFPGGGD cytoskeletal reorganization 17077177 2 1 0 Mutation of any of the 4 serines/threonines to alanine reduced the AILIM/ICOS-induced elongation ratio in activated T cells. Three sites are believed to be autophosphorylation sites, and one is believed to be an Akt1 site. Treatment with Akt inhibitor shows a reduction in this elongation ratio. +Ppp1r9b Spinophilin Adaptor/scaffold; Protein phosphatase, regulatory subunit O35274 84686 10q26 rat S177-p 448727 LLRQERAsLQDRKLD molecular association, regulation; intracellular localization endocytosis, induced ADRA2A(DISRUPTS) 12417592; 18367453; 23965992 3 1 0 +Crebbp CBP ACETYLTRANSFERASE; Acetyltransferase; DNA-binding; EC 2.3.1.48; Motility/polarity/chemotaxis; Nuclear receptor co-regulator; Transcription, coactivator/corepressor P45481 12914 16 A1|16 2.4 cM mouse T1872-p 474502 LMRRRMAtMNTRNVP transcription, induced 17166829 3 0 0 +PCNA PCNA Cell cycle regulation; DNA replication P12004 5111 20p12.3 human K164-sm 1316800 AVVISCAkDGVKFSA PCNA_C DNA repair, altered 16957771 3 2 0 promote DNA-damage independent spontaneous mutagenesis during replication-defects +ERBB4 HER4 EC 2.7.10.1; KINASE; Kinase, protein; Membrane protein, integral; Protein kinase, TK; Protein kinase, tyrosine (receptor) Q15303 2066 2q34 human Y733-p 457838 SGAFGTVyKGIWVPE PK_Tyr_Ser-Thr molecular association, regulation SHC1(INDUCES) 16729043 1 14 149 +SMARCAL1 SMARCAL1 EC 3.6.1.-; EC 3.6.4.-; Helicase Q9NZC9 50485 2q35 human S652-p 23146560 RLKSDVLsQLPAKQR SNF2-rel_dom intracellular localization; enzymatic activity, inhibited 23873943 1 2 1 induce DNA replication and regulates Genome integrity; prevent aberrant fork processing +PDE3A PDE3A EC 3.1.4.17; Membrane protein, integral; Membrane protein, multi-pass; Nucleotide Metabolism - purine; Phosphodiesterase Q14432 5139 12p12.2 human S312-p 456900 SKSHRRTsLPCIPRE enzymatic activity, induced 19261611 4 22 1 +Srebf1 SREBP-1 iso4 DNA-binding; Membrane protein, integral; Membrane protein, multi-pass; Transcription factor Q9WTN3-4 20787 11|11 B2 mouse S329-p 7996201 KSLKDLVsACGSGGG molecular association, regulation; activity, inhibited transcription, altered DNA(DISRUPTS) 19244231 1 0 0 regulates hepatic lipogenesis +Mapt Tau ACETYLTRANSFERASE; Acetyltransferase; Cytoskeletal P10637 17762 11 67.79 cM|11 E1 mouse T497-p 447933 SSPGSPGtPGSRSRT molecular association, regulation; protein conformation neural plasticity Tau(INDUCES) 33428131; 34220446; 34453977; 36186135 142 27 26 +Ntrk2 TrkB EC 2.7.10.1; KINASE; Kinase, protein; Membrane protein, integral; Protein kinase, TK; Protein kinase, tyrosine (receptor) Q63604 25054 17p14 rat K811-ub 2885000 TLLQNLAkASPVYLD phosphorylation signaling pathway regulation 18457658 1 0 0 NGF induced MAPK and Akt activation +MYB Myb DNA-binding; Oncoprotein; Transcription factor P01103 396244 chicken S116-p 448757 KYGPKRWsVIAKHLK Myb_DNA-binding molecular association, regulation transcription, inhibited DNA(DISRUPTS) 12456674 1 0 0 +Cttn Cortactin Actin-binding; Cytoskeletal; Motility/polarity/chemotaxis NP_001385572 60465 1q41-q42 rat Y421-p 447702 RPPSSPIyEDAAPLK carcinogenesis, induced; cell motility, induced; cell motility, altered; cell adhesion, altered; signaling pathway regulation 15383621; 16905744; 21725361 47 62 745 +PINX1 PINX1 Inhibitor; Nucleolus; Tumor suppressor Q96BK5 54984 8p23.1 human S117-p 14823407 SFSLEEKsKISKNRV protein degradation; ubiquitination 20573420 1 1 0 +ELK4 ELK4 DNA-binding; Transcription, coactivator/corepressor P28324 2005 1q32.1 human K125-ac 1875199900 KDVENGGkDKPPQPG molecular association, regulation transcription, induced BRD2(INDUCES) 32398865 1 1 0 +Cnr1 CNR1 GPCR, family 1; Membrane protein, integral; Membrane protein, multi-pass; Receptor, GPCR P20272 25248 5q21 rat S317-p 450999 IQRGTQKsIIIHTSE 7tm_1 activity, inhibited 9526000 1 5 2 Phosphorylation of CB1 at S317 suppressed modulation of ion channels by this receptor. +FZD2 FZD2 GPCR, Fz/Smo family; Membrane protein, integral; Membrane protein, multi-pass; Motility/polarity/chemotaxis; Receptor, GPCR Q14332 2535 17q21.31 human Y552-p 36744501 LHSWRKFyTRLTNSR Frizzled molecular association, regulation carcinogenesis, induced; cell motility, induced Fyn(INDUCES) 25417160 1 0 0 +Jund JunD Motility/polarity/chemotaxis; Transcription factor P52909 24518 16p14 rat S100-p 456168 LGLLKLAsPELERLI Jun transcription, induced 11719525; 17133482 5 63 12 +Slc6a3 DAT Membrane protein, integral; Membrane protein, multi-pass; Transporter; Transporter, SLC family P23977 24898 1p11 rat C580-pa 50592107 IYATYKFcSLPGSFR SNF intracellular localization 26424792 1 0 0 Ser7 phosphorylation and increased transport correlates with Cys580 palmitoylation, differentially modulate DA transport Vmax, presence of phosphorylation and palmitoylation on cell surface transporters +Pdc phosducin G protein regulator, misc. P20942 25343 13q21 rat S6-p 10431700 __MEEAAsQSLEEDF Phosducin molecular association, regulation G-gamma 2(DISRUPTS); G-beta 1(DISRUPTS) 11331285 1 0 0 +SH3BP4 SH3BP4 Cell cycle regulation; Vesicle Q9P0V3 23677 2q37.2 human S246-p 3214461 FRSKRSYsLSELSVL molecular association, regulation; intracellular localization cytoskeletal reorganization; signaling pathway regulation; endocytosis, inhibited 14-3-3 beta(INDUCES); EPS15(DISRUPTS); 14-3-3 epsilon(INDUCES); GIPC1(DISRUPTS) 33761321 2 39 0 binding to GPC1 regulates GPC1-NRP1 binding, regulates semaphorin signaling +LBR LBR DNA-binding; Membrane protein, integral; Membrane protein, multi-pass G1N806 turkey S80-p 14575427 SRRSRSRsRSRSPGR molecular association, regulation; protein conformation H3(INDUCES) 22056509 2 11 4 +IKBKB IKKB EC 2.7.11.10; KINASE; Kinase, protein; Protein kinase, Other; Protein kinase, Ser/Thr (non-receptor) O14920 3551 8p11.21 human K163-ub 486348 GEQRLIHkIIDLGYA Pkinase activity, induced; phosphorylation signaling pathway regulation 16267042 1 0 0 induces phosphorylation and activation of IKKB and it's substrates, regulation of signaling from cell surface TNF-R1 +RBM28 RBM28 Nucleolus; RNA splicing; RNA-binding Q9NW13 55131 7q32.1 human S122-p 3245387 RLIIRNLsFKCSEDD RRM_1 intracellular localization 34953860 1 4 0 +Dlg4 PSD-95 Adaptor/scaffold P31016 29495 10q24 rat S415-p 456446 REQLMNSsLGSGTAS protein conformation CRIPT(DISRUPTS) 21965656 1 10 0 Y397E mutant showed dissociation, triple mutant Y397E/S415E/S418E showed stronger dissociation +ABCA4 ABCA4 Membrane protein, integral; Membrane protein, multi-pass; Transporter; Transporter, ABC family P78363 24 1p22.1 human S1185-p 20940702 SCSSKGFsTTCPAHV enzymatic activity, induced 21721517 1 1 0 +Syk Syk EC 2.7.10.2; KINASE; Kinase, protein; Protein kinase, TK; Protein kinase, tyrosine (non-receptor) P48025 20963 13 A5|13 27.41 cM mouse Y519-p 447661 ALRADENyYKAQTHG PK_Tyr_Ser-Thr enzymatic activity, inhibited; phosphorylation; enzymatic activity, induced transcription, induced 27609517; 33761438; 35196496; 36166754 50 8 76 +Jak2 JAK2 EC 2.7.10.2; KINASE; Kinase, protein; Oncoprotein; Protein kinase, TK; Protein kinase, tyrosine (non-receptor) Q62120 16452 19 C1|19 23.73 cM mouse Y637-p 470140 KFGSLDTyLKKNKNS PK_Tyr_Ser-Thr enzymatic activity, induced 19364823 3 1 1 +Trp53 p53 iso2 Activator; DNA-binding; Motility/polarity/chemotaxis; Nuclear receptor co-regulator; Transcription factor; Tumor suppressor Q80ZA1 22059 11 B3|11 42.83 cM mouse S18-p 447490 ISLELPLsQETFSGL P53_TAD carcinogenesis, altered; cell motility, altered 21980358 480 12 0 decrease in the growth of p53S18A MEFs with the loss of Atm, lymphomas in 100% Atm-/-, p53 S18A/S18A mice +HSPA1A HSP70 Chaperone; Heat shock protein; Motility/polarity/chemotaxis P0DMV8 3303 6p21.33 human K126-ac 31089501 ISSMVLTkMKEIAEA HSP70 sumoylation autophagy, induced 23569248 1 1 0 acetylation induces sumoylation of PIK3C3 +IL22RA1 IL22RA1 Membrane protein, integral Q8N6P7 58985 1p36.11 human Y301-p 3579176 SLAQPVQySQIRVSG molecular association, regulation SHP-2(INDUCES) 20671117 1 1 5 necessary for IL22RA1 to mediate the IL-22-stimulated MAP kinases and STAT3 activation +VIM Vimentin Cytoskeletal; Motility/polarity/chemotaxis P08670 7431 10p13 human K97-ub 12306336 DAINTEFkNTRTNEK Filament_head protein degradation carcinogenesis, inhibited 31862882 1 5 25 RNF208 targets Ser39 phosphorylation inducing polyubiquitination-mediated degradation, and suppressing metastasis. +Dbn1 DBN1 Actin-binding; Cytoskeletal; Motility/polarity/chemotaxis Q07266 81653 17p14 rat S142-p 452446 NGLARLSsPVLHRLR cell motility, altered; cytoskeletal reorganization 25945928 6 87 28 phospho-dephospho cycle required for proper neuroblast orientation during polarized migration along the rostral migratory stream (RMS). +Atp1a1 ATP1A1 EC 3.6.3.9; Hydrolase; Membrane protein, integral; Membrane protein, multi-pass; Transporter; Transporter, ion channel P06685 24211 2q34 rat S943-p 451649 ICKTRRNsVFQQGMK Cation_ATPase_C activity, induced; molecular association, regulation; activity, inhibited 27013656; 36377055; 9435504 9 2 0 +STAP2 STAP2 Adaptor/scaffold Q9UGK3 55620 19p13.3 human Y310-p 6155352 LPNQEENyVTPIGDG transcription, altered 12540842 1 0 2 +RASSF1 RASSF1 iso2 Tumor suppressor Q9NS23-2 11186 3p21.31 human S131-p 486364 EWETPDLsQAEIEQK activity, induced; molecular association, regulation; intracellular localization carcinogenesis, altered; signaling pathway regulation; cell growth, altered XPA(INDUCES); RASSF1 iso2(INDUCES); MST2(INDUCES) 19962312; 22389451; 25368379 6 0 0 +Gria1 GluR1 Channel, calcium; Channel, ligand-gated; Membrane protein, integral; Membrane protein, multi-pass P23818 14799 11 B1.3|11 34.51 cM mouse T858-p 3362100 NEAIRTStLPRNSGA activity, induced; activity, inhibited; phosphorylation 17689977; 24706758 5 1 0 inhibits S863 phosphorylation; inhibits channel activity; synaptic plasticity +PSMD11 PSMD11 Protease; Proteasome complex O00231 5717 17q11.2 human S14-p 468525 VEFQRAQsLLSTDRE RPN6_N activity, induced; enzymatic activity, induced 26669444; 30782827 3 47 30 Increases proteosome activity +Notch1 Notch 1 Membrane protein, integral; Motility/polarity/chemotaxis; Oncoprotein; Receptor, misc.; Transcription factor Q01705 18128 2 A3|2 18.91 cM mouse K2154-ac 18899513 KARKPSTkGLACGSK protein stabilization; ubiquitination 21499261 2 1 0 +RIGI RIGI EC 3.6.4.13; Hydrolase O95786 23586 9p21.1 human K181-ub 486286 ALEKERNkFSELWIV CARD_2 protein degradation 26471729 3 2 0 +SLC12A6 KCC3 Membrane protein, integral; Membrane protein, multi-pass; Transporter; Transporter, SLC family Q9UHW9 9990 15q14 human S96-p 10787161 IEDLSQNsITGEHSQ activity, inhibited 24043619 2 5 2 Regulates the cotransporter activity +RPS10 RPS10 Nucleolus; RNA-binding; Ribosomal; Translation P46783 6204 6p21.31 human K138-ub 486965 AVPPGADkKAEAGAG translation, altered 32324387 2 11 139 translational read-through of poly(A) mRNA sequence (KAAA) 20, ZNF598 plays a role in this process +CPEB3 CPEB3 RNA-binding Q8NE35 22849 10q23.32 human K294-sm 1877467601 NPISPLKkPFSSNVI molecular association, regulation ACTB(DISRUPTS) 32848053 1 0 0 SUMOylation of CPEB3 is a potential inhibitor for the CPEB3/F-actin interaction +Sqstm1 SQSTM1 Autophagy; Nuclear receptor co-regulator; Ubiquitin conjugating system Q64337 18412 11|11 B1.3 mouse S409-p 40253303 QMLSMGFsDEGGWLT UBA_5 protein degradation; ubiquitination autophagy, induced 25723488 3 2 0 autophagic degradation of polyQ-Huntington mutant proteins +NFAT5 NFAT5 iso2 Transcription factor O94916-2 10725 16q22.1 human K282-ac 49199203 GRNTTPCkEVDIEGT RHD_DNA_bind molecular association, regulation transcription, inhibited DNA(DISRUPTS) 26297866 1 0 0 +P2RY4 P2RY4 GPCR, family 1; Membrane protein, integral; Membrane protein, multi-pass; Receptor, GPCR P51582 5030 Xq13.1 human S333-p 10349702 PQPRTAAsSLALVSL receptor desensitization, altered; receptor internalization, altered 11114308 1 0 0 +Vcl Vinculin Cell adhesion; Cytoskeletal; Motility/polarity/chemotaxis Q64727 22330 14 A3|14 11.53 cM mouse Y822-p 450873 KSFLDSGyRILGAVA Vinculin phosphorylation apoptosis, altered; cell motility, altered 15138291 5 45 1609 regulates ERK, PXN, and FAK phosphorylation +Jak2 JAK2 EC 2.7.10.2; KINASE; Kinase, protein; Oncoprotein; Protein kinase, TK; Protein kinase, tyrosine (non-receptor) Q62120 16452 19 C1|19 23.73 cM mouse Y317-p 7603503 TEQDVQLyCDFPDII Jak1_Phl enzymatic activity, inhibited 19364823 1 1 0 +CDKN1B p27Kip1 Cell cycle regulation; Inhibitor; Oncoprotein; Protein kinase, regulatory subunit P46527 1027 12p13.1 human S83-p 451426 WQEVEKGsLPEFYYR protein conformation 15034923 2 0 0 +MYL9 MRLC1 Contractile; Motility/polarity/chemotaxis P24844 10398 20q11.23 human S20-p 1863500 KRPQRATsNVFAMFD activity, induced; molecular association, regulation; intracellular localization carcinogenesis, induced; cell motility, induced; cell adhesion, induced; cell motility, altered; cytoskeletal reorganization; cell adhesion, altered; signaling pathway regulation 10092231; 12081505; 18854160; 21336303; 22136066; 26169356; 31834925; 34532864; 35594862; 37064875 49 65 294 +RPS6KA4 MSK2 EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, AGC; Protein kinase, Ser/Thr (non-receptor) O75676 8986 11q13.1 human S360-p 447953 PRIFQGYsFVAPSIL Pkinase_C enzymatic activity, induced 10806207 1 2 11 +AKT1 Akt1 EC 2.7.11.1; KINASE; Kinase, protein; Oncoprotein; Protein kinase, AGC; Protein kinase, Ser/Thr (non-receptor) P31749 207 14q32.33 human Y315-p 448519 TFCGTPEyLAPEVLE Pkinase enzymatic activity, induced transcription, altered 15994200; 20606012 5 2 13 +RGS16 RGS16 GAP; GAP, RGS O15492 6004 1q25.3 human Y168-p 448652 TLMEKDSyPRFLKSP RGS activity, induced; protein stabilization 11602604; 12588871 2 0 0 +LSM4 LSM4 RNA-binding; Spliceosome Q9Y4Z0 25804 19p13.11 human R117-m2 12190483 GVFGGRGrGGIPGTG molecular association, regulation SMN(INDUCES) 11720283 1 1 2 +KCNA5 Kv1.5 Channel, potassium; Membrane protein, integral; Membrane protein, multi-pass P22460 3741 12p13.32 human S559-p 1269647505 VQRKVSGsRGSFCKA activity, inhibited 30279167 1 0 0 mediates HPV +CCNE1 CCNE1 Activator; Cell cycle regulation; Nuclear receptor co-regulator P24864 898 19q12 human T395-p 447676 PLPSGLLtPPQSGKK protein degradation; molecular association, regulation; ubiquitination cell cycle regulation FBXW7(INDUCES); SKP2(INDUCES) 10500095; 10652300; 11237742; 15364936; 17434132; 19561641; 8861947 15 11 0 association in vitro and in vivo; T380 of cyclin E is necessary for for ubiquination and targeting to the proteosome. +RB1 Rb Nuclear receptor co-regulator; Oncoprotein; Transcription, coactivator/corepressor; Tumor suppressor P06400 5925 13q14.2 human T821-p 447983 KISEGLPtPTKMTPR Rb_C activity, induced; acetylation; molecular association, regulation cell cycle regulation; cell growth, induced; apoptosis, inhibited; transcription, induced; cell growth, altered Elf-1(DISRUPTS); E2F1(DISRUPTS); SP1(INDUCES); Rb(INDUCES); TFDP1(DISRUPTS); HDAC5(DISRUPTS) DNA(DISRUPTS) 16360038; 21880723; 22895174; 33419772; 34158578; 36047562; 8626527; 9315635 26 40 64 +Itgb1 ITGB1 Cell adhesion; Cell surface; Membrane protein, integral; Motility/polarity/chemotaxis; Receptor, misc. P09055 16412 8|8 E2 mouse T789-p 447709 IYKSAVTtVVNPKYE Integrin_b_cyt molecular association, regulation; activity, inhibited exocytosis, induced; cell growth, induced; cell differentiation, induced; cytoskeletal reorganization; cell adhesion, altered; transcription, altered; cell adhesion, inhibited FN1(DISRUPTS); kindlin-2(DISRUPTS); SNX17(DISRUPTS) 19555977; 24719112; 34996844; 35090553; 9512507 14 3 1 The TT788-9AA mutant is defective in mediating cell attachment and does not contribute to fibronectin fibril formation. +Tjp1 ZO1 Adaptor/scaffold; Motility/polarity/chemotaxis P39447 21872 7 C|7 35.02 cM mouse Y1164-p 450401 EEQPAPAyEVHNRYR cell cycle regulation; cell motility, altered 18515860 1 13 137 +HDAC5 HDAC5 DEACETYLASE; Deacetylase; EC 3.5.1.98; Hydrolase Q9UQL6 10014 17q21.31 human S611-p 14574360 VKDEEGEsGAEEGPD molecular association, regulation; intracellular localization MEF2D(DISRUPTS); GPS2(INDUCES); HDAC3(DISRUPTS); SMRT(INDUCES); N-CoR1(INDUCES); TBL1X(INDUCES); TBL1XR1(INDUCES) 24920159 2 20 0 interactions have been defined by quantitative mass spectrometry +Hmgcr HMGCR EC 1.1.1.34; Endoplasmic reticulum; Membrane protein, integral; Membrane protein, multi-pass; Motility/polarity/chemotaxis; Oxidoreductase; Secondary Metabolites Metabolism - terpenoid backbone biosynthesis P51639 25675 2q12 rat S871-p 448568 SHMVHNRsKINLQDL enzymatic activity, inhibited 2369897 5 11 0 +NFATC1 NFAT2 DNA-binding; Transcription factor O95644 4772 18q23 human S261-p 15412721 ARSSRPAsPCNKRKY protein stabilization 28235034 2 7 16 +EPAS1 HIF2A DNA-binding; Transcription factor Q99814 2034 2p21 human K385-ac 7761201 GKGAVSEkSNFLFTK transcription, inhibited 19498162 2 1 0 +KCNJ4 HIR Channel, potassium; Membrane protein, integral; Membrane protein, multi-pass P48050 3761 22q13.1 human T53-p 450871 IFTTCVDtRWRYMLM IRK activity, inhibited 10206975 1 0 0 Phosphorylation dramatically inhibits channel activity. +AHR AHR DNA-binding; Transcription factor P35869 196 7p21.1 human S12-p 451412 SANITYAsRKRRKPV intracellular localization transcription, altered 15063792 1 0 0 Dephosphorylated AhR enters the nucleus. +NUP62 NUP62 Adaptor/scaffold; Nucleoporin P37198 23636 19q13.33 human K432-ac 1883343300 HADEEREkTYKLAEN intracellular localization cell cycle regulation; cytoskeletal reorganization 36190325 1 0 0 Acetylation-elicited remodeling of nucleoporin complex regulates Nup62 on the mitotic spindle and proper spindle orientation and segregation, and the cortical localization of LGN?NuMA +KCNH2 Kv11.1 Channel, potassium; Membrane protein, integral; Membrane protein, multi-pass; Motility/polarity/chemotaxis Q12809 3757 7q36.1 human Y475-p 3496802 LINFRTTyVNANEEV Ion_trans activity, induced 18617000 1 0 0 +HNRNPK hnRNP K RNA splicing; RNA-binding; Spliceosome P61978 3190 9q21.32 human R299-m2 476714 PPPGRGGrGGSRARN protein stabilization; phosphorylation cell motility, induced 17191129; 31110205 3 6 11 +RAMAC RAMAC RNA processing Q9BTL3 83640 15q25.2 human S36-p 3210933 YLKRPPEsPPIVEEW RAM protein degradation; ubiquitination 27452456 1 44 1 +CFLAR CFLAR Apoptosis O15519 8837 2q33.1 human S193-p 7590803 LQAAIQKsLKDPSNN ubiquitination 19343040 1 2 0 +Crtc1 TORC1 Transcription factor Q157S1 684527 16p14 rat S167-p 18255800 MTPTQAEsFTGGPQD TORC_M intracellular localization; activity, inhibited apoptosis, altered; transcription, inhibited 21220102 2 0 0 +CDT1 CDT1 DNA replication; DNA-binding; Motility/polarity/chemotaxis; Oncoprotein Q9H211 81620 16q24.3 human S491-p 21440505 GSCCTIMsPGEMEKH CDT1_C protein stabilization; molecular association, regulation; activity, inhibited RAMP(DISRUPTS) 21930785 1 2 0 +Tlr3 TLR3 Membrane protein, integral; Receptor, cytokine Q99MB1 142980 8|8 B1.1 mouse K766-ub 1877292606 AYIIHAHkDRDWVWE TIR protein degradation; ubiquitination transcription, inhibited 31076723 1 1 0 K48 linked polyubiquitylation +Ripor2 FAM65B Cytoskeletal Q80U16 193385 13|13 A3.1 mouse S46-p 4746003 NGIIRSQsFAGFSGL PL48 activity, induced autophagy, inhibited 30349076 1 30 88 inhibits cell death +GSDME DFNA5 Tumor suppressor O60443 1687 7p15.3 human T6-p 50777052 __MFAKAtRNFLREV Gasdermin protein stabilization; molecular association, regulation; intracellular localization; protein conformation; activity, inhibited apoptosis, inhibited; signaling pathway regulation DFNA5(DISRUPTS); CASP3(DISRUPTS) 30976076; 37460805 2 2 0 +GPR84 GPR84 GPCR, family 1; Membrane protein, integral; Membrane protein, multi-pass; Motility/polarity/chemotaxis; Receptor, GPCR Q9NQS5 53831 12q13.13 human T263-p 1876864002 SEPVSAAtTQTLEGD 7tm_1 receptor internalization, induced; molecular association, regulation ARR3(INDUCES); ARRB2(INDUCES) 35427647 1 1 0 +SP4 SP4 C2H2-type zinc finger protein; DNA-binding; Transcription factor Q02446 6671 7p15.3 human S770-p 17548374 VAAISQDsNPATPNV protein degradation 26049820 3 5 0 S770 phosphorylation may regulate degradation, but may be other mechanism. +Grik5 GluR KA2 Channel, ligand-gated; Membrane protein, integral; Membrane protein, multi-pass Q63273 24407 1q21 rat T976-p 27535801 PTGPRELtEHE____ molecular association, regulation PSD-95(DISRUPTS) 23288040 1 0 0 necessary for KAR-LTD; increases expression of KARs at the plasma membrane; reduced at dendritic spines; increases lateral mobility of KARs +Ptpn11 SHP-2 EC 3.1.3.48; Motility/polarity/chemotaxis; PHOSPHATASE; Protein phosphatase, tyrosine (non-receptor) P35235 19247 5|5 F mouse Y304-p 451495 PNEPVSDyINANIIM Y_phosphatase molecular association, regulation GRB2(INDUCES) 8995399 2 2 56 +EZR Ezrin Cytoskeletal; Motility/polarity/chemotaxis P15311 7430 6q25.3 human Y354-p 448105 LMLRLQDyEEKTKKA ERM_helical activity, induced; molecular association, regulation; intracellular localization cell motility, altered; cytoskeletal reorganization PIK3R1(INDUCES) 10377409; 16873375; 24385580; 9230083 14 5 259 +GLS glutaminase Amino Acid Metabolism - alanine, aspartate and glutamate; Amino Acid Metabolism - arginine and proline; EC 3.5.1.2; Energy Metabolism - nitrogen; Hydrolase; Mitochondrial; Other Amino Acids Metabolism - D-Glutamine and D-glutamate O94925 2744 2q32.2 human K158-sc 1878180001 QEKIPVHkFITALKS protein stabilization autophagy, induced 30910998 1 0 0 suppresses its Lys48-linked ubiquitination +Gata4 GATA4 Motility/polarity/chemotaxis; Transcription factor Q08369 14463 14 D1|14 33.24 cM mouse S261-p 450013 IKPQRRLsASRRVGL protein stabilization; molecular association, regulation; acetylation p300(INDUCES) 22674427 9 1 1 +NFE2L2 NRF2 DNA-binding; Transcription factor Q16236 4780 2q31.2 human K516-ac 7106317 VAAQNCRkRKLENIV bZIP_Maf molecular association, regulation transcription, induced DNA(INDUCES) 19273602 1 1 0 +Adam22 ADAM22 Cell adhesion; Membrane protein, integral; Motility/polarity/chemotaxis Q9R1V6 11496 5 A1|5 3.39 cM mouse S832-p 469108 NGRPRSNsWQGNMGG protein stabilization; molecular association, regulation endocytosis, inhibited 14-3-3 epsilon(INDUCES); AP2M1 iso2(DISRUPTS) 34910912 2 24 97 +PKD2 PKD2 Channel, cation; Membrane protein, integral; Membrane protein, multi-pass Q13563 5311 4q22.1 human S829-p 4696848 HSSRRRGsISSGVSY activity, induced cell cycle regulation; cell growth, induced; transcription, induced 23390129; 26269590 3 5 0 +HNF4A HNF4 alpha DNA-binding; Nuclear receptor; Transcription factor P41235 3172 20q13.12 human S167-p 458371 VLSRQITsPVSGING molecular association, regulation transcription, induced PC4(INDUCES) 16351573 4 5 28 +NFKB1 NFkB-p105 DNA-binding; Transcription factor P19838 4790 4q24 human K440-ub 5018600 GTMDTESkKDPEGCD molecular association, regulation; protein processing DNA(INDUCES) 10207090 1 0 0 +RGS3 RGS3 GAP; GAP, RGS P49796 5998 9q32 human S943-p 469926 SLRRRTHsEGSLLQE molecular association, regulation transcription, altered 14-3-3 zeta(INDUCES); G-alpha(q)(DISRUPTS) 11985497 1 34 54 +USP25 USP25 DEUBIQUITINASE; EC 3.4.19.12; Protease; Ubiquitin conjugating system; Ubiquitin-specific protease Q9UHP3 29761 21q21.1 human T727-p 40407603 QKLRESEtSVTTAQA ubiquitination; enzymatic activity, inhibited 25755282 1 0 0 in vitro deubiquitination assays +Jak2 JAK2 EC 2.7.10.2; KINASE; Kinase, protein; Oncoprotein; Protein kinase, TK; Protein kinase, tyrosine (non-receptor) Q62120 16452 19 C1|19 23.73 cM mouse Y813-p 451492 NSLFTPDyELLTEND molecular association, regulation SH2-B-beta(INDUCES) 15121872; 28912580 8 3 2 +PDCL PhLP G protein regulator, misc. Q13371 5082 9q33.2 human S19-p 448824 KLQYYYSsSEDEDSD molecular association, regulation G-gamma 2(INDUCES); CCTA(INDUCES) 15889144; 16717095 4 3 3 PhLP phosphorylation at S18-S20 induces association of G-gamma(2) with a G-beta(1)/PhLP complex. These PhLP phosphorylations are also required for normal G-beta/G-gamma dimer assembly.; facilitates dimerization of subunits beta and gamma of G-protein +POLI POLI DNA repair, damage; EC 2.7.7.7; Transferase Q9UNA4 11201 18q21.2 human K335-ub 50771304 SEEDSFKkCSSEVEA IMS_C protein degradation 26370087 1 1 0 +OPRK1 KOR-1 GPCR, family 1; Membrane protein, integral; Membrane protein, multi-pass; Receptor, GPCR P41145 4986 8q11.23 human S358-p 1975303 RMERQSTsRVRNTVQ ubiquitination; enzymatic activity, induced signaling pathway regulation 18212250; 23086943 2 0 1 S358 phosphorylation enhances KOR-1 ubiquitination; KOR-agonist-induced signaling for p38 MAPK/ERK1/2 activation +PPP2R5A PPP2R5A Motility/polarity/chemotaxis; Protein phosphatase, regulatory subunit Q15172 5525 1q32.3 human S28-p 459127 VDGFTRKsVRKAQRQ activity, induced; intracellular localization apoptosis, altered 18957415 2 0 8 increases mitochondrial PP2A activity +POLR2A POLR2A EC 2.7.7.48; EC 2.7.7.6; Nucleotide Metabolism - purine; Nucleotide Metabolism - pyrimidine; Transcription initiation complex; Transferase P24928 5430 17p13.1 human S1621-p 3439802 SYSPTSPsYSPTSPS RNA_pol_Rpb1_R molecular association, regulation; phosphorylation transcription, induced; transcription, altered INTS11(INDUCES); POLR1B(INDUCES) 18079403; 18079404; 19901026; 20457598; 22137580 13 2 0 transcription of small nuclear RNA genes; snRNA expression and processing, decrease in S1616 phosphorylation; phosphorylation correlated with transcription +HDAC1 HDAC1 DEACETYLASE; Deacetylase; EC 3.5.1.98; Hydrolase; Nuclear receptor co-regulator Q13547 3065 1p35.2-p35.1 human K218-ac 4219805 LRDIGAGkGKYYAVN Hist_deacetyl enzymatic activity, inhibited transcription, inhibited 16762839 1 0 0 +EIF5 EIF5 Translation; Translation initiation P55010 1983 14q32.32 human S389-p 448029 LKEAEEEsSGGEEED W2 molecular association, regulation cell cycle regulation; translation, altered eIF2-alpha(INDUCES) 16227438; 18649047 3 52 44 +Grik5 GluR KA2 Channel, ligand-gated; Membrane protein, integral; Membrane protein, multi-pass Q63273 24407 1q21 rat S892-p 19014315 LSNGKLYsAGAGGDA molecular association, regulation PSD-95(DISRUPTS) 23288040 2 1 0 necessary for KAR-LTD; increases expression of KARs at the plasma membrane; reduced at dendritic spines; increases lateral mobility of KARs +TP53 p53 Activator; DNA-binding; Motility/polarity/chemotaxis; Nuclear receptor co-regulator; Transcription factor; Tumor suppressor P04637 7157 17p13.1 human S378-p 447534 SKKGQSTsRHKKLMF activity, induced; molecular association, regulation; intracellular localization cell cycle regulation; chromatin organization, altered; transcription, induced S100B(DISRUPTS); p53(INDUCES); 14-3-3 zeta(INDUCES); 14-3-3 epsilon(INDUCES); BLM(DISRUPTS); S100A2(DISRUPTS); 14-3-3 gamma(INDUCES); WRN(DISRUPTS) DNA(INDUCES) 11585729; 12080066; 17898864; 18812399; 19819244; 19933256; 9315650; 9620776 15 2 0 S376/3787 phosphorylated peptides inhibited helicase activityin vitro. S15 phosphorylated p53 colocalized with BLM in vivo. +DNMT1 DNMT1 Amino Acid Metabolism - cysteine and methionine; Cell development/differentiation; EC 2.1.1.37; METHYLTRANSFERASE; Methyltransferase; Methyltransferase, DNA; Transcription regulation P26358 1786 19p13.2 human K739-sm 12726302 SWVGEAVkTDGKKSY enzymatic activity, induced DNA(INDUCES) 19450230 1 0 0 +EGR1 EGR1 C2H2-type zinc finger protein; DNA-binding; Transcription factor P18146 1958 5q31.2 human K272-sm 1872377900 GLGTPDQkPFQGLES phosphorylation carcinogenesis, inhibited; cell growth, inhibited; transcription, induced 19057511 1 0 0 Phosphorylation of EGR1 is necessary for EGR1 sumoylation, PTEN transcription +Rps6ka1 p90RSK EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, AGC; Protein kinase, Ser/Thr (non-receptor); Translation P18653 20111 4|4 D2.3 mouse S352-p 447989 TSRTPRDsPGIPPSA Pkinase_C enzymatic activity, induced 14726002 42 47 4 +BAP1 BAP1 DEUBIQUITINASE; EC 3.4.19.12; Protease; Tumor suppressor; Ubiquitin conjugating system; Ubiquitin-specific protease Q92560 8314 3p21.1 human S592-p 477921 SIRPIQGsQGSSSPV intracellular localization DNA repair, induced 24211834; 24347639 2 5 7 +PTPRE PTPRE EC 3.1.3.48; Membrane protein, integral; Motility/polarity/chemotaxis; PHOSPHATASE; Receptor protein phosphatase, tyrosine P23469 5791 10q26.2 human N23-ng 1871141700 LARALRGnETTADSN phosphorylation 31722979 1 0 0 mutants decrease phosphorylation +Dennd1a DENND1A GEF; GEF, Rab; Vesicle Q8K382 227801 2|2 B mouse S538-p 484448 RTLKESDsAEGDETE molecular association, regulation 14-3-3 epsilon(INDUCES) 26055712 1 10 1 +Wnk4 WNK4 EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, Other; Protein kinase, Ser/Thr (non-receptor) Q80UE6 69847 11|11 D mouse S1196-p 5879855 PGIMRRNsLSGSSTG enzymatic activity, induced 28096417 5 11 9 +MDM4 MDM4 EC 6.3.2.-; Ligase; UBIQUITIN LIGASE; Ubiquitin conjugating system; Ubiquitin ligase O15151 4194 1q32.1 human S314-p 62381100 TECKKFNsPSKRYCF zf-RanBP protein stabilization; molecular association, regulation; intracellular localization MDM2(INDUCES) 27927748 1 1 0 nuclear localization +DPYSL2 CRMP-2 Microtubule-binding; Motility/polarity/chemotaxis Q16555 1808 8p21.2 human S522-p 448082 PASSAKTsPAKQQAP molecular association, regulation; intracellular localization; phosphorylation carcinogenesis, inhibited; apoptosis, induced; cell differentiation, induced; cell motility, altered; cytoskeletal reorganization DRP1(DISRUPTS); RHOT2(DISRUPTS); RECK(DISRUPTS); TUBB3(INDUCES); MFN2(DISRUPTS) 16611631; 32019603; 32778769; 33401710; 34831395; 37174687 31 49 84 +RIPK3 RIPK3 EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, Ser/Thr (non-receptor); Protein kinase, TKL Q9Y572 11035 14q12 human T182-p 1174709701 GSGEPGGtLGYLAPE Pkinase molecular association, regulation; enzymatic activity, induced apoptosis, induced PELI1(INDUCES); MLKL(INDUCES) 29883609 1 1 0 pT182 leads to induced necroptosis. interaction of pT182 with PELI1 leads to RIPK3 ubiquitination and degradation. +NFKBIA IkB-alpha DNA-binding; Inhibitor P25963 4792 14q13.2 human Y289-p 1867984206 ESEDEESyDTESEFT signaling pathway regulation 30887112 1 0 0 NF-kB activation in BCR signaling +ECPAS ECM29 Vesicle Q5VYK3 23392 9q31.3 human S1414-p 51146701 SGLTDRNsVIQKSCA molecular association, regulation DYNC1I1(INDUCES) 26609957 1 0 0 increased retrograde transport of proteasomes in growing axons +PLAGL2 PLAGL2 C2H2-type zinc finger protein; DNA-binding Q9UPG8 5326 20q11.21 human K250-sm 483049 SQELLKIkTEPVDML intracellular localization cell growth, induced; transcription, inhibited 16207715 3 0 0 +Smc1a Smc1 DNA replication; RNA splicing Q9CU62 24061 X|X F3 mouse S957-p 448697 ISQEEGSsQGEESVS SMC_N DNA repair, induced; cell growth, induced; apoptosis, inhibited; transcription, inhibited 33524014 19 20 68 +PDCL PhLP G protein regulator, misc. Q13371 5082 9q33.2 human S18-p 448823 EKLQYYYsSSEDEDS molecular association, regulation G-gamma 2(INDUCES); CCTA(INDUCES) 15889144; 16717095 4 4 2 PhLP phosphorylation at S18-S20 induces association of G-gamma(2) with a G-beta(1)/PhLP complex. These PhLP phosphorylations are also required for normal G-beta/G-gamma dimer assembly.; facilitates dimerization of subunits beta and gamma of G-protein +NR1I2 PXR DNA-binding; Nuclear receptor O75469 8856 3q13.33 human K109-ac 54468600 CLESGMKkEMIMSDE zf-C4 molecular association, regulation; protein conformation transcription, inhibited RXRA(DISRUPTS) DNA(DISRUPTS) 26855179 1 1 0 inhibits dimerization +HIPK2 HIPK2 EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, CMGC; Protein kinase, Ser/Thr (non-receptor) Q9H2X6 28996 7q34 human S882-p 29668001 IVIPDTPsPTVSVIT protein stabilization; molecular association, regulation; protein conformation; phosphorylation; enzymatic activity, induced apoptosis, induced PIN1(INDUCES) 24145406 1 0 0 +FOXO3 FOXO3A Autophagy; DNA-binding; Oncoprotein; Transcription factor O43524 2309 6q21 human S30-p 478738 EPQSRPRsCTWPLQR transcription, induced 29445193 1 3 3 activate mitochondrial transcription in surviving cells, while the FoxO3A-S12A/S30A mutant contributed to apoptosis induction in metabolically stressed cancer cells. +KLF10 KLF10 C2H2-type zinc finger protein; DNA-binding; Transcription factor Q13118 7071 8q22.3 human S206-p 7320931 NIPCAAVsPNRSKCE protein stabilization cell cycle regulation; cell growth, inhibited SIAH1(DISRUPTS) 25728284 1 13 1 +FOXC2 FOXC2 Apoptosis; Cell development/differentiation; DNA-binding; Transcription factor Q99958 2303 16q24.1 human S281-p 3210588 NIMTLRTsPPGGELS molecular association, regulation transcription, altered DNA(INDUCES) 23878394 1 8 0 implicated in vascular remodeling in vivo +XIAP XIAP Apoptosis; EC 6.3.2.-; Ligase; UBIQUITIN LIGASE; Ubiquitin conjugating system; Ubiquitin ligase P98170 331 Xq25 human S430-p 22547400 QDESSQTsLQKEIST molecular association, regulation apoptosis, induced IRF3(INDUCES) 22072751 1 2 0 +Gsk3b GSK3B EC 2.7.11.1; EC 2.7.11.26; KINASE; Kinase, protein; Protein kinase, CMGC; Protein kinase, Ser/Thr (non-receptor) Q9WV60 56637 16|16 B3 mouse Y216-p 448569 RGEPNVSyICSRYYR Pkinase activity, induced; protein degradation; molecular association, regulation; phosphorylation; enzymatic activity, induced cell differentiation, inhibited; neural plasticity; cell growth, induced; cell differentiation, induced; transcription, inhibited; signaling pathway regulation SNCA(INDUCES) 17403689; 21445308; 21998135; 32209671; 33655459; 33829789; 36103829; 36293516 98 128 4206 +CHRNA7 nAChRA7 Channel, cation; Channel, ligand-gated; Membrane protein, integral; Membrane protein, multi-pass P36544 1139 15q13.3 human Y442-p 457467 KILEEVRyIANRFRC Neur_chan_memb activity, inhibited 16251431 1 0 1 +Sirt2 SIRT2 DEACETYLASE; Deacetylase; EC 3.5.1.- Q8VDQ8 64383 7|7 B1 mouse S372-p 482810 TTISPGKsPPPAKEA intracellular localization transcription, altered 35443760 2 21 1 +CIRBP CIRBP RNA-binding; Spliceosome; Translation Q14011 1153 19p13.3 human T43-p 801662700 VVVKDREtQRSRGFG RRM_1 intracellular localization 29432179 1 0 0 may be cause of its exclusion from the DNA-damaged regions +MAT1A MAT1A Amino Acid Metabolism - cysteine and methionine; EC 2.5.1.6; Other Amino Acids Metabolism - selenoamino acid; Transferase Q00266 4143 10q22.3 human S114-p 27996470 LVALEQQsPDIAQCV S-AdoMet_synt_N protein degradation; molecular association, regulation; intracellular localization PIN1(INDUCES) 35091576 1 3 0 +Nrf1 NRF1 DNA-binding; Transcription factor Q9WU00 18181 6 A3.3|6 12.47 cM mouse S384-p 1883500602 EATQAVAsLAEAAVA molecular association, regulation transcription, induced DNA(DISRUPTS) 37409632 1 0 0 +PTEN PTEN Carbohydrate Metabolism - inositol phosphate; EC 3.1.3.16; EC 3.1.3.48; EC 3.1.3.67; Motility/polarity/chemotaxis; Nuclear receptor co-regulator; PHOSPHATASE; Phosphatase, lipid; Tumor suppressor P60484 5728 10q23.31 human K289-ub 27490408 GPEETSEkVENGSLC PTEN_C2 intracellular localization 22103913 6 0 0 nuclear import +SLC6A4 SERT Membrane protein, integral; Membrane protein, multi-pass; Transporter P31645 6532 17q11.2 human T276-p 456508 SIWKGVKtSGKVVWV SNF activity, induced; protein conformation 16112691; 17310063; 17913921; 35258286 7 1 0 +PGR PR DNA-binding; Nuclear receptor; Transcription factor P06401 5241 11q22.1 human S162-p 450156 PATQRVLsPLMSRSG Prog_receptor transcription, induced 8662865 5 6 0 +SP7 osterix C2H2-type zinc finger protein; DNA-binding; Transcription factor Q8TDD2 121340 12q13.13 human S76-p 15334100 TSTNGLLsPAGSPPA molecular association, regulation transcription, induced AML3(INDUCES) 25122769; 27498006 4 0 0 transcriptional activity on the Cx43 promoter +TSC2 TSC2 Cell cycle regulation; GAP; GAP, misc.; Nuclear receptor co-regulator; Tumor suppressor P49815 7249 16p13.3 human S1132-p 448500 RDRVRSMsGGHGLRV activity, inhibited 27451907 5 40 20 cell survival induced +Sirt1 SIRT1 Apoptosis; DEACETYLASE; Deacetylase; EC 3.5.1.-; Nuclear receptor co-regulator Q923E4 93759 10|10 B4 mouse T522-p 6006905 HLSELPPtPLHISED molecular association, regulation; acetylation; enzymatic activity, induced cell differentiation, inhibited; apoptosis, altered p53(DISRUPTS) 20167603; 28364022 7 3 40 promotes cell survival; hepatic fatty acid oxidation +H2ax H2AX DNA repair, damage; DNA-binding; Helicase P27661 15270 9 A5.2|9 24.84 cM mouse S139-p 448841 GKKASQAsQEY____ activity, induced; molecular association, regulation DNA repair, induced; chromatin organization, altered; apoptosis, induced; transcription, induced; DNA repair, inhibited MDC1(INDUCES) 11571274; 16818236; 18158901; 31488723; 33594057; 33961949; 35393561 289 32 29 +CELF1 CELF1 Cell development/differentiation; RNA processing; RNA-binding Q92879 10658 11p11.2 human S178-p 29668006 AQTMEGCsSPMVVKF RRM_1 RNA splicing, altered 24151077 1 1 0 splicing regulation in diabetes +Gabrg2 GABRG2 Channel, chloride; Channel, ligand-gated; Membrane protein, integral; Membrane protein, multi-pass; Transporter; Transporter, ion channel P22723 14406 11 A5|11 24.8 cM mouse Y411-p 455817 LQERDEEyGYECLDG Neur_chan_memb activity, induced; receptor internalization, altered 19903874 7 0 0 spatial object recognition in mice +FSCN1 fascin Actin-binding; Cytoskeletal; Motility/polarity/chemotaxis Q16658 6624 7p22.1 human K247-ub 15388565 LKAGKATkVGKDELF Fascin cytoskeletal reorganization 27879315 1 2 1 fascin bundling activity +NLRP7 NLRP7 Apoptosis Q8WX94 199713 19q13.42 human K379-ub 1881209001 TLKLQMEkGEDPVPT protein degradation; ubiquitination 33838681 1 0 0 +Hcn1 HCN1 Membrane protein, integral; Membrane protein, multi-pass O88704 15165 13 D2.3|13 66.34 cM mouse S867-p 23112242 VTLFRQMsSGAIPPN molecular association, regulation 14-3-3 zeta(INDUCES) 35679272 2 1 3 +MDM4 MDM4 EC 6.3.2.-; Ligase; UBIQUITIN LIGASE; Ubiquitin conjugating system; Ubiquitin ligase O15151 4194 1q32.1 human S403-p 474540 DLAHSSEsQETISSM protein degradation; molecular association, regulation; ubiquitination; intracellular localization; protein conformation translation, induced USP7(DISRUPTS); MDM2(DISRUPTS); MDM2(INDUCES); p53(DISRUPTS) 15788536; 16163388; 19432880; 19808970; 22120712; 24813712; 27215386 13 2 0 interaction MDM4 with MDM2 ; lower level of MDM4 ubiquitination were observed on the triple mutant S342/367/403/A; MDM4342/A367A/403A mutant is resistant to MDM2 degradation after DNA damage, but is degradated after ARF expression. ; formation of HDMX-HDM2 heterodimer +MRPS23 MRPS23 Mitochondrial; Ribosomal; Translation Q9Y3D9 51649 17q22 human R21-m1 8093824 SRTRDLVrAGVLKEK MRP-S23 protein degradation; ubiquitination carcinogenesis, induced; cell motility, induced 33927350 1 2 2 promote degradation to a low level; promotes breast cancer metastasis, OXPHOS inhibition, mtROS production, +SUPT5H SPT5 RNA-binding; Transcription, coactivator/corepressor O00267 6829 19q13.2 human R696-m2 475965 GGSGGMSrGRGRRDN transcription, inhibited 12718890 1 1 0 inhibition of in vitro transcription assays and HIV-1 gene expression +IDH2 IDH2 Carbohydrate Metabolism - citrate (TCA) cycle; EC 1.1.1.42; Mitochondrial; Other Amino Acids Metabolism - glutathione; Oxidoreductase P48735 3418 15q26.1 human K166-ac 1194129 RLVPGWTkPITIGRH Iso_dh enzymatic activity, inhibited 32457458 2 8 12 oncometabolite 2-hydroxyglutarate (2HG) production +Eef2k EEF2K EC 2.7.11.20; KINASE; Kinase, protein; Protein kinase, Ser/Thr (non-receptor); Protein kinase, atypical; Translation P70531 25435 1q36 rat S358-p 447826 GTEEKCGsPRIRTLS enzymatic activity, inhibited 25182533 6 3 6 +SNPH syntaphilin iso2 Membrane protein, integral; Vesicle O15079-2 9751 20p13 human S56-p 23150247 LPGSRRTsAGSRRRT cell growth, induced 34087103 1 1 1 +FGF14 FGF14 Cell development/differentiation; Cytokine Q92915 2259 13q33.1 human Y153-p 1875395600 KESVFENyYVIYSSM FGF molecular association, regulation neural plasticity SCN2A(INDUCES) 34831326 1 0 0 +Ryr2 RYR2 Channel, ligand-gated; Membrane protein, integral; Membrane protein, multi-pass; Transporter; Transporter, ion channel E9Q401 20191 13 A1|13 4.38 cM mouse S2813-p 458801 ISQTSQVsIDAAHGY activity, induced; molecular association, regulation; protein conformation apoptosis, induced; signaling pathway regulation PDCD8(DISRUPTS); Calmodulin(DISRUPTS); IDH3B(DISRUPTS) 21098440; 21888910; 24498331; 24949568; 27318036; 28105734; 33755308; 33941260; 34200203 63 8 5 +CTCF CTCF C2H2-type zinc finger protein; Transcription factor; Tumor suppressor Q08705 396274 chicken S610-p 448304 RSKKEDSsDSEENAE transcription, altered; cell growth, altered 11238955 1 8 1 +Fmr1 FMR1 Nucleolus; RNA-binding; Translation P35922 14265 X A7.1|X 34.83 cM mouse S499-p 469583 NSEASNAsETESDHR FXMRP1_C_core molecular association, regulation; ubiquitination; phosphorylation neural plasticity; translation, altered; translation, induced; translation, inhibited CDH1(DISRUPTS); RCAN1(INDUCES) 14570712; 18160642; 18474609; 22099464; 22863780; 25913861; 27957526; 31118285 21 6 0 +GNAS G-alpha(s) G protein; G protein, heterotrimeric; G protein, heterotrimeric alpha G(s); Membrane protein, peripheral; Oncoprotein; Vesicle P63092 2778 20q13.32 human K28-ac 1883454301 EANKKIEkQLQKDKQ molecular association, regulation; intracellular localization carcinogenesis, induced STAT3(INDUCES) 35344606 1 1 0 mediates its cytoplasm translocation +ACTB ACTB Cytoskeletal; Motility/polarity/chemotaxis P60709 60 7p22.1 human K61-ac 461692 VGDEAQSkRGILTLK Actin molecular association, regulation CAP2(INDUCES); INF2(INDUCES) 31871199 2 7 264 acetyl-mimetic actin mutants inhibit INF2-mediated actin polimerization, CAP/Ac-actin binds INF2-DAD +Nfil3 E4BP4 DNA-binding; Transcription factor O08750 18030 13 B1|13 27.68 cM mouse S353-p 7321245 EGMQKLSsPADAIAK Vert_IL3-reg_TF transcription, inhibited 29311361 1 16 0 NK cell production inhibited +CASP2 CASP2 Apoptosis; EC 3.4.22.55; Protease P42575 835 7q34 human S164-p 241497501 STDTVEHsLDNKDGP molecular association, regulation 14-3-3 zeta(INDUCES) 28943433 1 2 0 +ILF3 NFAT90 DNA-binding; Nucleolus; RNA-binding; Transcription factor Q12906 3609 19p13.2 human S647-p 3496801 RGRGRGGsIRGRGRG intracellular localization translation, altered; transcription, altered 18097023; 20870937 2 0 0 regulates IL-2 production in T cells; required for NFAT90 export; stabilizes IL-2 mRNA +Raf1 RAF1 EC 2.7.11.1; KINASE; Kinase, protein; Oncoprotein; Protein kinase, Ser/Thr (non-receptor); Protein kinase, TKL Q99N57 110157 6 E3|6 53.62 cM mouse S43-p 447744 FGYQRRAsDDGKLTD enzymatic activity, inhibited cell growth, altered 11997508 17 23 5 +MT-CO1 COX1 EC 1.9.3.1; Energy Metabolism - oxidative phosphorylation; Membrane protein, integral; Membrane protein, multi-pass; Mitochondrial; Oxidoreductase P00395 4512 - human K481-ac 1879877106 EAFASKRkVLMVEEP apoptosis, induced 31647884 1 0 0 mutant sites were found to significantly suppressed the AAPH-evoked increase in both ROS level and apoptosis +KCNN4 KCNN4 Channel, potassium; Membrane protein, integral; Membrane protein, multi-pass O15554 3783 19q13.31 human H358-p 474525 FRQVRLKhRKLREQV CaMBD activity, induced 17157250; 18796614 3 1 0 +CSF1R CSFR EC 2.7.10.1; KINASE; Kinase, protein; Membrane protein, integral; Oncoprotein; Protein kinase, TK; Protein kinase, tyrosine (receptor) P07333 1436 5q32 human Y699-p 451527 DPEGGVDyKNIHLEK PK_Tyr_Ser-Thr molecular association, regulation PIK3CB(INDUCES) 1708091 14 6 32 +CAMK4 CAMK4 EC 2.7.11.17; KINASE; Kinase, protein; Protein kinase, CAMK; Protein kinase, Ser/Thr (non-receptor) Q16566 814 5q22.1 human S13-p 2135601 VPSCSASsCSSVTAS transcription, altered 8702940 1 0 0 +Pi4k2a PI4K2A EC 2.7.1.67; Kinase, lipid; Motility/polarity/chemotaxis Q2TBE6 84095 19 C3|19 35.74 cM mouse S9-p 2022757 DETSPLVsPERAQPP phosphorylation 25083612 2 16 0 +SLA SLAP Adaptor/scaffold Q13239 6503 8q24.22 human Y258-p 1018109 KKSISLMyGGSKRKS activity, inhibited 24284075 1 1 1 oncogenic c-Kit bypasses the normal cellular negative feedback control +DIAPH2 Diaphanous-2 iso4 Cytoskeletal; Motility/polarity/chemotaxis Q17R91 1730 Xq21.33 human S196-p 18707506 CLESLRVsLTSNPVS Drf_GBD cell cycle regulation; chromatin organization, altered; cytoskeletal reorganization 21397845 1 1 0 mutation of this site disrupts metaphase chromosome alignment +MAX MAX iso2 DNA-binding; Transcription factor P61244-2 4149 14q23.3 human S11-p 449308 NDDIEVEsDADKRAH activity, inhibited transcription, altered 8018564 5 28 0 phosphorylation-deficient mutant inhibits transcription more efficiently +SSH1 SSH1 EC 3.1.3.16; EC 3.1.3.48; PHOSPHATASE; Protein phosphatase, dual-specificity Q8WYL5 54434 12q24.11 human S402-p 10989184 MGVSRSAsTVIAYAM DSPc molecular association, regulation; enzymatic activity, inhibited cell motility, altered 21525957 2 1 7 +Grm1 mGluR1 GPCR, family 3; Membrane protein, integral; Membrane protein, multi-pass; Receptor, GPCR P23385 24414 1p13 rat T695-p 453089 GSKKKICtRKPRFMS 7tm_3 receptor desensitization, altered 10823959 1 0 0 Rapid desensitization of mGluR1 is dependent on T695 phosphorylation. +Ncor2 SMRT Nuclear receptor co-regulator; Transcription, coactivator/corepressor Q9WU42 20602 5|5 G1.1 mouse K668-sm 14988614 ILQQHKLkMEKERNA transcription, induced 20555024 1 0 0 +CDKN1B p27Kip1 Cell cycle regulation; Inhibitor; Oncoprotein; Protein kinase, regulatory subunit P46527 1027 12p13.1 human K73-sm 1873284320 NHKPLEGkYEWQEVE CDI intracellular localization carcinogenesis, induced; cell growth, induced 28882106 1 0 0 +STK4 MST1 Autophagy; EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, STE; Protein kinase, Ser/Thr (non-receptor) Q13043 6789 20q13.12 human Y433-p 463558 KIPQDGDyEFLKSWT Mst1_SARAH protein stabilization; molecular association, regulation; enzymatic activity, inhibited; phosphorylation; enzymatic activity, induced apoptosis, induced FOXO3A(INDUCES) 21715626; 30903103 3 13 110 +GSTP1 GSTP1 EC 2.5.1.18; Other Amino Acids Metabolism - glutathione; Transferase; Xenobiotic Metabolism - drug metabolism - cytochrome P450; Xenobiotic Metabolism - metabolism by cytochrome P450 P09211 2950 11q13.2 human Y199-p 463460 AFLASPEyVNLPING protein conformation; enzymatic activity, induced apoptosis, inhibited JNK1(INDUCES) 19254954; 26429914 3 2 24 +CTNNB1 CTNNB1 Actin-binding; Cell adhesion; Motility/polarity/chemotaxis; Nuclear receptor co-regulator; Oncoprotein; Transcription factor P35222 1499 3p22.1 human S552-p 472273 QDTQRRTsMGGTQQQ activity, induced; molecular association, regulation; protein stabilization; ubiquitination; intracellular localization; activity, inhibited carcinogenesis, induced; carcinogenesis, altered; cell motility, induced; apoptosis, induced; transcription, induced; transcription, altered; signaling pathway regulation; cell growth, induced; apoptosis, inhibited; cell motility, altered; cytoskeletal reorganization; transcription, inhibited 14-3-3 zeta(INDUCES); CEACAM1(INDUCES) 17287208; 20419129; 22094462; 24117889; 32195176; 33605402; 33832512; 34656562; 34657130; 34749529; 35059735; 35697802; 35715860; 35986102; 36008464; 36114575; 36181792; 36348350; 36435833; 36928362 44 64 9 +DYNLT1 DYNLT1 Microtubule-binding; Motility/polarity/chemotaxis; Motor P63172 6993 6q25.3 human S82-p 470041 AGLHTASsCFWDSST Tctex-1 molecular association, regulation cytoskeletal reorganization Rhodopsin(INDUCES); DNCLI1(DISRUPTS) 16956385; 24170091 2 0 1 S82E mutant showed significant microtubule breakage, compared to hypoxia control, release of cytochrome c agravated, ATP synthesis was lower in S82E mutant ; S82E mutant TCTEL1 is excluded, while S82A mutant protein is impaired in release, from dynein complexes; S82E and S82A mutants cause relocalization of rhodopsin +MYC Myc DNA-binding; Nucleolus; Oncoprotein; Transcription factor P01106 4609 8q24.21 human K341-sm 37036406 YPAAKRVkLDSVRVL Myc_N protein degradation; ubiquitination transcription, inhibited 25895136 2 3 0 +IRS2 IRS2 Adaptor/scaffold; Motility/polarity/chemotaxis Q9Y4H2 8660 13q34 human S577-p 483923 GLRKRTYsLTTPARQ intracellular localization 34253290 2 40 11 disassociation of IRS2 from plasma membrane to cytosol; limits PM-associated PI3K and PIP3 synthesis +CCDC6 CCDC6 Apoptosis; Cytoskeletal; Oncoprotein Q16204 8030 10q21.2 human S359-p 3197330 SPIPYTPsPSSSRPI protein degradation; molecular association, regulation cell cycle regulation FBXW7(INDUCES) 23108047; 25885523 2 7 24 +CNR1 CNR1 GPCR, family 1; Membrane protein, integral; Membrane protein, multi-pass; Receptor, GPCR P21554 1268 6q15 human S425-p 999609 TAQPLDNsMGDSDCL molecular association, regulation; protein conformation ARRB2(INDUCES) 17910957 3 4 0 +TWIST1 TWIST1 Cell development/differentiation; DNA-binding; Inhibitor; Transcription regulation Q15672 7291 7p21.1 human S123-p 14821303 RERQRTQsLNEAFAA HLH protein degradation; molecular association, regulation TWIST1(INDUCES); TCF12(DISRUPTS) 26759241; 32179550 5 1 0 induces EMT; bimolecular fluorescence complementation (BiFC) assay +TICRR TICRR Cell cycle regulation; DNA replication Q7Z2Z1 90381 15q26.1 human T969-p 20798601 LTKSVAEtPVHKQIS Treslin_N molecular association, regulation cell cycle regulation TOPBP1(INDUCES) 21700459; 25737283; 35231445 3 3 11 DNA replication induced; shortens S phase, increases replication initiation +PRKD2 PRKD2 EC 2.7.11.13; KINASE; Kinase, protein; Motility/polarity/chemotaxis; Protein kinase, CAMK; Protein kinase, Ser/Thr (non-receptor) Q9BZL6 25865 19q13.32 human S876-p 448800 QGLAERIsVL_____ enzymatic activity, induced 11062248; 12058027 5 10 1 +MAPKAPK2 MAPKAPK2 EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, CAMK; Protein kinase, Ser/Thr (non-receptor) P49137 9261 1q32.1 human T334-p 448273 QSTKVPQtPLHTSRV activity, induced; phosphorylation; enzymatic activity, induced transcription, inhibited 16278218; 23740979; 35189144; 8846784 31 14 38 +GSR GSR EC 1.8.1.7; Other Amino Acids Metabolism - glutathione; Oxidoreductase P00390 2936 8p12 human T507-p 23111522 TKADFDNtVAIHPTS Pyr_redox_dim enzymatic activity, induced carcinogenesis, induced; apoptosis, inhibited 31530934 1 1 1 ROS level maintenance +DLG4 PSD-95 Adaptor/scaffold P78352 1742 17p13.1 human T19-p 3609101 YRYQDEDtPPLEHSP protein stabilization; molecular association, regulation; protein conformation; palmitoylation neural plasticity Calmodulin(INDUCES); PIN1(INDUCES) 29118000; 32231520; 32256312 8 0 0 +Ptk2 FAK EC 2.7.10.2; KINASE; Kinase, protein; Protein kinase, TK; Protein kinase, tyrosine (non-receptor) O35346 25614 7q34 rat Y397-p 447887 SVSETDDyAEIIDEE activity, induced; molecular association, regulation; intracellular localization; enzymatic activity, induced; phosphorylation apoptosis, altered; apoptosis, inhibited; cytoskeletal reorganization; cell adhesion, altered; signaling pathway regulation; transcription, altered LYN(INDUCES); NMDAR2A(INDUCES); NMDAR2B(INDUCES) 10794722; 10848597; 12732587; 12764094; 12805241; 14627993; 15923313; 16407217; 16690621; 21357465; 21660950; 34194565 371 31 474 induces ERK signaling; focal adhesion inhibition/dissociation; integrin Rac1-NADPH oxidase signaling +Ncor1 N-CoR1 Nuclear receptor co-regulator; Transcription, coactivator/corepressor Q60974 20185 11|11 B2 mouse S2345-p 2888300 KLINKSNsRKSKSPI molecular association, regulation 14-3-3 beta(INDUCES) 17630505 1 0 0 +BRMS1 BRMS1 Tumor suppressor Q9HCU9 25855 11q13.2 human S30-p 25284673 MNGEEEEsEEERSGS protein degradation; molecular association, regulation; intracellular localization 14-3-3 epsilon(INDUCES) 26980766 1 1 1 nuclear export to cytoplasm, degradation and metastases +Add2 ADD2 Cytoskeletal; Motility/polarity/chemotaxis Q05764 24171 4q34 rat S725-p 449803 KKKEKVEs_______ intracellular localization cytoskeletal reorganization 9679146 2 0 0 +MDM4 MDM4 EC 6.3.2.-; Ligase; UBIQUITIN LIGASE; Ubiquitin conjugating system; Ubiquitin ligase O15151 4194 1q32.1 human S342-p 470031 SKLTHSLsTSDITAI protein degradation; molecular association, regulation; ubiquitination; intracellular localization USP7(DISRUPTS); MDM2(DISRUPTS); 14-3-3 theta(INDUCES); 14-3-3 gamma(INDUCES); MDM2(INDUCES); p53(DISRUPTS) 15788536; 16163388; 16943424; 19432880; 19808970; 22120712; 24190973 12 7 3 +LATS1 LATS1 EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, AGC; Protein kinase, Ser/Thr (non-receptor); Tumor suppressor O95835 9113 6q25.1 human K860-ub 1875093000 FRWTHDSkYYQSGDH Pkinase protein degradation; intracellular localization carcinogenesis, induced; cell motility, induced; cell growth, induced; transcription, induced 34593639 1 0 0 PRAMEF2-induced nuclear localization of YAP which resulted in induction of genes involved in key cancer-associated pathways. +NLRP3 NLRP3 Inhibitor Q96P20 114548 1q44 human Y861-p 59041400 SHSLTRLyVGENALG activity, inhibited 27043286 1 0 0 reduced IL-1B secretion, regulates inflammasome activation +NEK7 NEK7 EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, Other; Protein kinase, Ser/Thr (non-receptor) Q8TDX7 140609 1q31.3 human S204-p 3207291 VGTPYYMsPERIHEN Pkinase molecular association, regulation NLRP3(DISRUPTS) 31762063 1 6 1 +MPL MPL Membrane protein, integral; Receptor, cytokine P40238 4352 1p34.2 human Y591-p 454722 SSQAQMDyRRLQPSC molecular association, regulation; phosphorylation carcinogenesis, induced; cell differentiation, induced; signaling pathway regulation Syk(INDUCES); SHP-1(INDUCES) 24607955; 33384332; 36229456 5 3 15 regulates TPO mediated signaling; regulates TPO-R signaling; induces phosphorylation of Syk, ERK1/2. MAPK pathway regulation +SLC30A2 SLC30A2 Membrane protein, integral; Membrane protein, multi-pass; Transporter; Transporter, SLC family Q9BRI3 7780 1p36.11 human K4-ub 34666302 ____MEAkEKQHLLD protein degradation; ubiquitination 25016022 1 0 0 zinc accumulation and secretion +Pparg PPAR-gamma iso2 DNA-binding; Nuclear receptor; Transcription factor P37238-2 19016 6 E3|6 53.41 cM mouse S82-p 448062 AIKVEPAsPPYYSEK intracellular localization cell growth, induced; transcription, induced 21690289; 27769068 33 7 0 promoter of PFKFB4 +RPA2 RFA2 DNA replication P15927 6118 1p35.3 human S11-p 1854600 SGFESYGsSSYGGAG molecular association, regulation; intracellular localization DNA repair, induced; cell growth, altered WRN(INDUCES) 17035231; 21107010 3 0 0 upon replication blockage, WRN and RPA functionally interact ; 7xAlanine mutant has defect in down regulating DNA synthesis following UV treatment. 7xAspartate mutant did not localize to S-phase foci. +Gab1 GAB1 Adaptor/scaffold; Motility/polarity/chemotaxis Q9QYY0 14388 8|8 C2 mouse Y307-p 447944 MRHVSISyDIPPTPG molecular association, regulation; enzymatic activity, induced cell differentiation, altered; cell motility, induced; apoptosis, inhibited; signaling pathway regulation; cell growth, altered PLCG1(INDUCES) 10734310; 33786575 6 1 41 FoxO1-GAB1-pAKT signaling +CABP1 CABP1 Adaptor/scaffold; Calcium-binding; Inhibitor Q9NZU7 9478 12q24.31 human S323-p 12521706 TNGDGEIsTSELREA EF-hand_7 activity, induced 14685260 1 0 0 +ERRFI1 MIG-6 Inhibitor; Tumor suppressor Q9UJM3 54206 1p36.23 human Y395-p 454989 KVSSTHYyLLPERPP molecular association, regulation EGFR(INDUCES) 26967626; 32574989 4 9 140 +FLT3 FLT3 EC 2.7.10.1; KINASE; Kinase, protein; Membrane protein, integral; Oncoprotein; Protein kinase, TK; Protein kinase, tyrosine (receptor) P36888 2322 13q12.2 human Y599-p 448643 VDFREYEyDLKWEFP molecular association, regulation; enzymatic activity, induced; phosphorylation Src(INDUCES); SHP-2(INDUCES); Fyn(INDUCES) 11971190; 16684964; 26848862 7 0 2 +TRIP10 TRIP10 Adaptor/scaffold; Motility/polarity/chemotaxis; Nuclear receptor co-regulator Q15642 9322 19p13.3 human T225-p 1868832804 DMDERRAtRLGAGYG molecular association, regulation; intracellular localization endocytosis, induced; carcinogenesis, induced; cell motility, induced; cytoskeletal reorganization CDC42(INDUCES) 31319138 1 0 0 +SALL4 SALL4 iso3 C2H2-type zinc finger protein; Cancer Testis Antigen (CTA); DNA-binding Q9UJQ4-2 57167 20q13.2 human K316-sm 31089510 GLAPFTLkPDGTRVL protein stabilization; molecular association, regulation; intracellular localization transcription, induced Oct4(DISRUPTS) 23012367 1 0 0 +Sstr3 SSTR3 GPCR, family 1; Membrane protein, integral; Membrane protein, multi-pass; Receptor, GPCR P30936 171044 7q34 rat T357-p 456711 GSGPPEKtEEEEDEE receptor internalization, altered 9295322 2 0 0 +PPP1R3F PPP1R3F Membrane protein, integral; Protein phosphatase, regulatory subunit Q6ZSY5 89801 Xp11.23 human S18-p 22497900 LRHSAPPsPAAGEPR signaling pathway regulation 21668450 1 5 0 regulation of glycogen synthesis via R3F-PP1 signaling in astrocytoma cells +PKN1 PKN1 EC 2.7.11.13; KINASE; Kinase, protein; Protein kinase, AGC; Protein kinase, Ser/Thr (non-receptor) Q16512 5585 19p13.12 human S533-p 483281 ATGTGTFsPGASPGS enzymatic activity, induced carcinogenesis, induced; cell motility, induced; cell growth, induced 31981797 1 29 3 induces anchorage-independent cell growth +BRD4 BRD4 KINASE; Kinase, protein; Protein kinase, Ser/Thr (non-receptor); Protein kinase, atypical O60885 23476 19p13.12 human S494-p 27806303 DSSSDSSsDSDSSTD molecular association, regulation p53(INDUCES) 23317504 1 1 0 +Klf1 KLF1 C2H2-type zinc finger protein; DNA-binding; Transcription factor P46099 16596 8 41.3 cM|8 C3 mouse T23-p 457383 TLGQFLDtQEDFLKW EKLF_TAD1 activity, induced transcription, altered 9722526 1 0 0 +AATF AATF Nucleolus; RNA-binding; Transcription factor Q9NY61 26574 17q12 human T366-p 27136800 FTVYRNRtLQKWHDK AATF-Che1 molecular association, regulation; intracellular localization apoptosis, inhibited MRLC3(DISRUPTS) 22909821 1 1 0 nuclear translocation +EHMT2 EHMT2 Amino Acid Metabolism - lysine degradation; EC 2.1.1.43; METHYLTRANSFERASE; Methyltransferase; Methyltransferase, protein lysine Q96KQ7 10919 6p21.33 human S211-p 18009234 EIQHFRMsDDVHSLG molecular association, regulation; intracellular localization DNA repair, induced H3(INDUCES); RPA1(INDUCES) 28698370 1 3 0 recruitment to chromatin +INPP5D SHIP EC 3.1.3.86; Motility/polarity/chemotaxis; Phosphatase, lipid Q92835 3635 2q37.1 human S33-p 1869876001 GSFLVRAsESISRAY SH2 protein stabilization carcinogenesis, induced; cell growth, induced 31377397 1 0 0 +WASF1 WAVE1 Cytoskeletal; Motility/polarity/chemotaxis Q92558 8936 6q21 human Y125-p 457673 PIPLQETyDVCEQPP molecular association, regulation cytoskeletal reorganization Arp3(INDUCES) 16317717 1 0 0 +AKAP1 AKAP1 Adaptor/scaffold; Membrane protein, integral; Mitochondrial; RNA-binding Q92667 8165 17q22 human S151-p 465540 PLECPLSsPKGVLFS molecular association, regulation PPP1CA(DISRUPTS) 16669629 1 13 0 +ARHGEF2 ARHGEF2 GEF; GEF, Rac/Rho; Motility/polarity/chemotaxis Q92974 9181 1q22 human S172-p 460815 LGLRRILsQSTDSLN molecular association, regulation; intracellular localization cytoskeletal reorganization TUBB2B(DISRUPTS) 21513698 2 17 71 inhibits microtubule binding and stabilization, acetylation, regulates cell polarization +Nr4a2 NR4A2 DNA-binding; Nuclear receptor Q07917 54278 3q21 rat K577-sm 2407418 LQRIFYLkLEDLVPP Hormone_recep transcription, inhibited 14559918 2 0 0 +RAN RAN Cell cycle regulation; G protein; G protein, monomeric; G protein, monomeric, Ran; Motility/polarity/chemotaxis; Nuclear export; Nuclear receptor co-regulator P62826 5901 12q24.33 human S135-p 469112 DRKVKAKsIVFHRKK Ras molecular association, regulation; intracellular localization cell cycle regulation RANGAP1(DISRUPTS); RCC1(DISRUPTS) 16930555; 20805321 2 19 4 +Fzd3 FZD3 GPCR, Fz/Smo family; Membrane protein, integral; Membrane protein, multi-pass; Receptor, GPCR Q61086 14365 14 D1|14 34.09 cM mouse S577-p 18507003 DQRSKAGsVHSKVSS receptor internalization, inhibited; phosphorylation endocytosis, inhibited 21316586 1 0 0 enhances PCP signaling, regulating c-Jun phosphorylation, and affecting growth cone guidance +FPR1 FPR1 GPCR, family 1; Membrane protein, integral; Membrane protein, multi-pass; Motility/polarity/chemotaxis; Receptor, GPCR P21462 2357 19q13.41 human S332-p 450851 TEDSTQTsDTATNST molecular association, regulation; receptor desensitization, altered; receptor internalization, altered ARRB2(INDUCES) 10514456; 16622009 3 1 0 +Ubtf UBF DNA-binding; Nucleolus; Transcription factor P25977 25574 10q32.1 rat T201-p 448505 DIPEKPKtPQQLWYT HMG_box transcription, inhibited 11741541 1 11 3 +Mfn2 MFN2 Cell cycle regulation; Cytoskeletal; EC 3.6.5.-; Hydrolase; Membrane protein, integral; Membrane protein, multi-pass; Mitochondrial Q80U63 170731 4|4 E2 mouse S442-p 4746700 AEEIRRLsVLVDEYQ cell differentiation, inhibited; autophagy, induced 32165499 6 2 0 induces mitophagy +DEPTOR DEPTOR Apoptosis Q8TB45 64798 8q24.12 human S263-p 7101486 RKSTSFMsVSPSKEI protein degradation; molecular association, regulation carcinogenesis, induced; apoptosis, inhibited; signaling pathway regulation mTOR(DISRUPTS) 19446321 2 3 0 PI3K-Akt signaling +Sox11 SOX11 DNA-binding; Transcription factor Q7M6Y2 20666 12|12 A2 mouse S289-p 50800237 PPAPPALsPASSRCV protein degradation cell differentiation, induced 34431536 2 3 0 +IKBKE IKKE EC 2.7.11.10; Inhibitor; KINASE; Kinase, protein; Protein kinase, Other; Protein kinase, Ser/Thr (non-receptor) Q14164 9641 1q32.1 human Y179-p 23115344 SVYGTEEyLHPDMYE Pkinase enzymatic activity, induced cell motility, induced 27287717 1 1 4 +HCLS1 HS1 Adaptor/scaffold; Motility/polarity/chemotaxis P14317 3059 3q13.33 human Y222-p 452057 MEAPTTAyKKTTPIE activity, induced; molecular association, regulation cell motility, induced ARPC2(INDUCES) 22679023 4 4 155 HS1 phosphorylation mediates neutrophil chemotaxis and induce Rac activation +KRAS KRas iso2 G protein; G protein, monomeric; G protein, monomeric, Ras; Motility/polarity/chemotaxis; Oncoprotein P01116-2 3845 12p12.1 human K104-ac 35480405 REQIKRVkDSEDVPM Ras protein conformation; enzymatic activity, altered signaling pathway regulation; cell growth, altered 28154176 6 3 0 KRas K104Q mutant, KRas downstream signaling +RHOT1 RHOT1 EC 3.6.5.-; G protein; G protein, monomeric; G protein, monomeric, Rho; Hydrolase; Membrane protein, integral; Mitochondrial Q8IXI2 55288 17q11.2 human K194-ub 27206526 KALTRIFkISDQDND protein degradation; intracellular localization autophagy, induced 34152608 1 2 0 induces mitophagy by recruiting Parkin to mitochondria +Cxcr4 CXCR4 GPCR, family 1; Membrane protein, integral; Membrane protein, multi-pass; Receptor, GPCR P70658 12767 1 E3|1 56.43 cM mouse S353-p 7997136 SVSTESEsSSFHSS_ receptor internalization, induced; receptor desensitization, inhibited; phosphorylation 23734232 1 3 0 +Cited1 CITED1 Nuclear receptor co-regulator P97769 12705 X D|X 45.25 cM mouse S65-p 27937113 NGVPTSSsGSTSPIG CITED intracellular localization cell differentiation, induced 23529225 1 0 0 S63/64/65/67/69/73/79/80/84A mutation in CITED1 inhibits its translocation into the nucleus and osteoblasts differentiation +CDK1 CDK1 Cell cycle regulation; EC 2.7.11.22; EC 2.7.11.23; KINASE; Kinase, protein; Motility/polarity/chemotaxis; Protein kinase, CMGC; Protein kinase, Ser/Thr (non-receptor) P06493 983 10q21.2 human Y15-p 447610 EKIGEGTyGVVYKGR Pkinase molecular association, regulation; intracellular localization; enzymatic activity, inhibited; activity, inhibited; phosphorylation; enzymatic activity, altered cell cycle regulation; carcinogenesis, induced; carcinogenesis, inhibited; cell growth, inhibited; transcription, induced; cell growth, induced; apoptosis, inhibited; cytoskeletal reorganization PKM iso2(INDUCES); CDC25C(DISRUPTS) 10504341; 10770932; 11782384; 12049736; 12912980; 14767478; 14987992; 15141014; 1532335; 15735676; 15975956; 17976513; 1850698; 19276355; 19917613; 19933706; 20347419; 20360007; 21389100; 21602434; 21900495; 22850745; 24240236; 24391510; 24798733; 24910099; 25744022; 25849598; 30626720; 33796458; 33971703; 34168048; 34370741; 34570813; 34676045; 34773074; 34799355; 35056723; 35081344; 35348191; 35392228; 35738066; 36163549; 36967563; 8441405; 9268380 201 145 3902 +Hspa8 HSC70 Chaperone; Heat shock protein; Nucleolus; RNA-binding P63017 15481 9 A5.1|9 21.55 cM mouse K561-m3 3898513 EDEKLQGkINDEDKQ HSP70 protein stabilization autophagy, induced 31346037 3 5 5 stabilization of HSC70 enhances the function in chaperone-mediated autophagy, the degradation of client proteins such as transcription factors myocyte enhancer factor 2A (Mef2A) and Mef2D +BUB1B BUB1B EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, Other; Protein kinase, Ser/Thr (non-receptor); Tumor suppressor O60566 701 15q15.1 human T680-p 484623 IEDSREAtHSSGFSG molecular association, regulation cell cycle regulation PPP2R5A(INDUCES) 23079597 5 0 0 T680 is independent of attachment status and may correlate with lack of interkinetochore tension.; kinetochore-microtubule attachment +CNR1 CNR1 GPCR, family 1; Membrane protein, integral; Membrane protein, multi-pass; Receptor, GPCR P21554 1268 6q15 human S429-p 999608 LDNSMGDsDCLHKHA molecular association, regulation; protein conformation ARRB2(INDUCES) 17910957 3 3 0 +IDH2 IDH2 Carbohydrate Metabolism - citrate (TCA) cycle; EC 1.1.1.42; Mitochondrial; Other Amino Acids Metabolism - glutathione; Oxidoreductase P48735 3418 15q26.1 human K106-ac 461227 DSALATQkYSVAVKC Iso_dh enzymatic activity, inhibited 32457458 2 8 39 oncometabolite 2-hydroxyglutarate (2HG) production +PIKFYVE PIKFYVE Carbohydrate Metabolism - inositol phosphate; EC 2.7.1.150; KINASE; Kinase, lipid; Motility/polarity/chemotaxis; Protein kinase, Ser/Thr (non-receptor) Q9Y2I7 200576 2q34 human S307-p 457532 PARNRSAsITNLSLD enzymatic activity, induced 15546921 3 55 145 +MAP2K2 MEK2 EC 2.7.12.2; KINASE; Kinase, protein; Protein kinase, STE; Protein kinase, dual-specificity (non-receptor) P36507 5605 19p13.3 human S226-p 448074 LIDSMANsFVGTRSY Pkinase enzymatic activity, induced signaling pathway regulation 19106095; 21893193 56 19 201 PI3K/mTOR/p70S6K pathway +MDM2 MDM2 EC 6.3.2.-; EC 6.3.2.19; Inhibitor; Ligase; NEDDYLATION LIGASE; Neddylation Ligase; Nucleolus; Oncoprotein; UBIQUITIN LIGASE; Ubiquitin conjugating system; Ubiquitin ligase Q00987 4193 12q15 human S253-p 2132107 SVEFEVEsLDSEDYS activity, induced 12167711 2 1 0 promotes p53 degradation +FGD5 FGD5 GEF; GEF, Rac/Rho Q6ZNL6 152273 3p25.1 human Y820-p 464904 TANENDGyVDMSSFN activity, induced; enzymatic activity, induced cytoskeletal reorganization 31088862; 31267715 2 4 16 induces its activity as a GEF for Cdc42; responsible for Cdc42 activation and inhibition of thrombin-induced permeability; not necessary for recruitment of FGD5 to endothelial junctions +NUP98 NUP98 iso2 Motility/polarity/chemotaxis; Nucleoporin P52948-2 4928 11p15.4 human T653-p 478067 IAKPIPQtPESAGNK intracellular localization 21335236 1 32 18 as multiple sites (13PM) mutant +TP53 p53 Activator; DNA-binding; Motility/polarity/chemotaxis; Nuclear receptor co-regulator; Transcription factor; Tumor suppressor P04637 7157 17p13.1 human S15-p 447490 PSVEPPLsQETFSDL P53_TAD protein degradation; acetylation; protein stabilization; molecular association, regulation; activity, inhibited; phosphorylation; activity, induced; ubiquitination; intracellular localization; protein conformation cell cycle regulation; carcinogenesis, induced; apoptosis, altered; carcinogenesis, inhibited; cell growth, inhibited; apoptosis, induced; transcription, induced; signaling pathway regulation; transcription, altered; autophagy, induced; cell growth, induced; chromatin organization, altered; transcription, inhibited; cell growth, altered PKHF1(INDUCES); MDM4(DISRUPTS); BLM(DISRUPTS); S100A1(INDUCES); UBE4B(INDUCES); CBP(INDUCES); MDM2(DISRUPTS); S100A6(INDUCES); MDC1(DISRUPTS); PPP2R5C(INDUCES); TRIM24(INDUCES); NFkB-p65(INDUCES); S100B(INDUCES); DACH1(INDUCES); S100A4(INDUCES); NFkB-p100(DISRUPTS); MDM2(INDUCES); WRN(DISRUPTS); S100A2(INDUCES) DNA(INDUCES) 10606744; 10656682; 10734067; 10958792; 11030628; 11258706; 11314044; 11397945; 11707453; 11861384; 11865061; 11875057; 12071847; 12080066; 12324477; 12393500; 12427754; 12518062; 12771937; 12860987; 12955074; 14665630; 14712210; 15155458; 15159397; 15181149; 15471885; 15489892; 15775976; 16322229; 16501611; 16651424; 16714289; 16731759; 17535811; 17668048; 17891183; 17967874; 17976513; 17977830; 18056442; 18272544; 18769132; 18778462; 18794113; 19203586; 19819244; 20024960; 20353948; 20372057; 20696760; 20962272; 21317932; 21383696; 21465263; 21765463; 22030623; 22975381; 23798621; 24657168; 24820418; 25202122; 26104798; 26588988; 26673821; 26742101; 27208501; 27630139; 28153791; 31296660; 31968249; 32001619; 32061892; 32083004; 33097607; 33687951; 33745968; 33755959; 33761896; 33982778; 34103468; 34103685; 34282274; 34496248; 34523970; 34711610; 35301407; 35393546; 36007676; 36214635; 36225643; 36243702; 36541910; 36575468; 36611139; 9363941 480 12 0 +AMOTL2 AMOTL2 Cell adhesion Q9Y2J4 51421 3q22.2 human K408-ub 21128806 ANRRLASkTQEAQAG molecular association, regulation; phosphorylation cell growth, inhibited; cell motility, inhibited; transcription, inhibited YAP1(INDUCES); LATS2(INDUCES) 26598551 1 2 0 +CCNE1 CCNE1 Activator; Cell cycle regulation; Nuclear receptor co-regulator P24864 898 19q12 human S399-p 454414 GLLTPPQsGKKQSSG activity, induced; protein degradation; molecular association, regulation; intracellular localization cell cycle regulation FBXW7(INDUCES) 14536078; 15364936; 17434132; 28137908 5 2 1 decreased CCNE1 stabilization (abundance) +Ikzf1 Ikaros C2H2-type zinc finger protein; DNA-binding; Transcription factor Q03267 22778 11 A1|11 7.02 cM mouse S392-p 451352 PSNSCQDsTDTESNA activity, inhibited cell cycle regulation DNA(DISRUPTS) 15024069 1 0 2 +RIGI RIGI EC 3.6.4.13; Hydrolase O95786 23586 9p21.1 human K203-ub 1879755400 ETEDLEDkMETSDIQ protein degradation 31881323 1 0 0 +ATF3 ATF-3 Transcription factor P18847 467 1q32.3 human K42-sm 31094511 ANLTPFVkEELRFAI carcinogenesis, induced; cell growth, induced; transcription, induced; transcription, inhibited 22991139; 23591848 3 1 0 +KDM3A JMJD1A DEMETHYLASE; Demethylase; EC 1.14.11.-; Nuclear receptor co-regulator; Oxidoreductase Q9Y4C1 55818 2p11.2 human Y1114-p 35527104 ITPEDRKyGTTNLHL enzymatic activity, inhibited transcription, induced 25148682 1 0 0 +Nefh NFH Cytoskeletal P16884 24587 14q21 rat S493-p 455548 GEEAATTsPPAEEAA protein degradation; protein conformation 28882840 3 7 3 S493A aperikaryal NF aggregates; S493D NFH accumulation within axonal NFs, transport of NFH into and along axons +RUNX3 AML2 DNA-binding; Transcription factor Q13761 864 1p36.11 human K171-m2 1877292605 ATYHRAIkVTVDGPR Runt molecular association, regulation cell cycle regulation; carcinogenesis, induced; cell growth, induced; transcription, inhibited CBFB(DISRUPTS); p300(DISRUPTS) 33116296 1 1 0 +NUAK1 NuaK1 EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, CAMK; Protein kinase, Ser/Thr (non-receptor) O60285 9891 12q23.3 human S476-p 33406502 KKTQQREsGYYSSPE molecular association, regulation cell cycle regulation BRD8(INDUCES) 24785407 1 1 0 +PPP1R16B PPP1R16B Motility/polarity/chemotaxis; Protein phosphatase, regulatory subunit Q96T49 26051 20q11.23 human S69-p 17549547 KKVSFEAsVALLEAS intracellular localization cell motility, induced 34343028 1 2 3 +Mapk11 P38B EC 2.7.11.24; KINASE; Kinase, protein; Protein kinase, CMGC; Protein kinase, Ser/Thr (non-receptor) Q9WUI1 19094 15|15 E3 mouse Y323-p 477552 DEPEAEPyDESVEAK activity, induced cell growth, induced; signaling pathway regulation 21715315 1 0 0 p38 pathway activation, Induce T cell proliferation and Th Skewing, reduce autoimmunity and inflammation +MRTFA MKL1 Oncoprotein; Transcription, coactivator/corepressor Q969V6 57591 22q13.1-q13.2 human K576-sm 2407401 APLGTPVkQENSFSS transcription, inhibited 16098147 1 2 0 +GLI1 GLI1 C2H2-type zinc finger protein; Oncoprotein; Transcription factor P08151 2735 12q13.3 human S102-p 41595602 LQTVIRTsPSSLVAF activity, induced; protein degradation; molecular association, regulation; ubiquitination; intracellular localization; activity, inhibited carcinogenesis, inhibited; cell growth, inhibited; transcription, induced SUFU(DISRUPTS); BTRC(INDUCES) 26190112; 28562331; 35831023 3 1 0 +BAX BAX Apoptosis; Membrane protein, integral; Mitochondrial; Tumor suppressor Q07812 581 19q13.33 human T174-p 28847907 TPTWQTVtIFVAGVL TM intracellular localization apoptosis, induced 23907458 1 0 0 +CETN2 CETN2 Calcium-binding; Cell cycle regulation; DNA repair, damage P41208 1069 Xq28 human T118-p 28735101 KLFDDDEtGKISFKN EF-hand_7 intracellular localization 23844208 1 0 0 localization to the centrosome, capacity to form linear structures +TOB1 TOB1 Adaptor/scaffold; Cell cycle regulation P50616 10140 17q21.33 human S320-p 1869290801 YGGLNEKsFVDGLNF carcinogenesis, induced; cell motility, induced; cell growth, induced 31497236 1 1 0 +FFAR4 GPR120 iso1 GPCR, family 1; Lipid-binding; Membrane protein, integral; Membrane protein, multi-pass; Receptor, GPCR Q5NUL3-1 338557 10q23.33 human S373-p 31014806 SVKRNDLsIISG___ receptor internalization, induced; molecular association, regulation ARR3(INDUCES); ARRB1(INDUCES) 24412271; 24817122 3 1 0 +CEBPA C/EBP-alpha DNA-binding; Transcription factor P49715 1050 19q13.11 human K326-ac 56394106 SDNDRLRkRVEQLSR bZIP_2 cell differentiation, inhibited 27005833 2 0 0 +Ncoa3 SRC-3 ACETYLTRANSFERASE; Acetyltransferase; EC 2.3.1.48; Motility/polarity/chemotaxis; Nuclear receptor co-regulator; Transcription, coactivator/corepressor O09000 17979 2|2 H3 mouse S536-p 454108 SLLSTLSsPGPKLDN NCOA_u2 carcinogenesis, inhibited; cell growth, inhibited; cell differentiation, induced; transcription, inhibited; signaling pathway regulation 20534466 7 0 0 inhibits insulin/IGF1 signaling +WNK1 WNK1 EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, Other; Protein kinase, Ser/Thr (non-receptor) Q9H4A3 65125 12p13.33 human S1261-p 483845 AGRRFIVsPVPESRL molecular association, regulation; enzymatic activity, induced OSR1(DISRUPTS); STLK3(DISRUPTS) 17190791; 22032326 1 20 3 +Ctnnd1 CTNND1 Actin-binding; Adaptor/scaffold; Cell adhesion; G protein regulator, misc.; Motility/polarity/chemotaxis P30999 12388 2 D|2 49.45 cM mouse S252-p 450456 MEGYRAPsRQDVYGP molecular association, regulation cell adhesion, inhibited 26175155 6 54 205 decreased homophilic binding affinity of E-cadherin +HIF1A HIF1A Autophagy; DNA-binding; Transcription factor Q16665 3091 14q23.2 human K547-ub 12723509 FAEDTEAkNPFSTQD protein degradation 16862177 2 1 0 +MTOR mTOR Autophagy; EC 2.7.11.1; KINASE; Kinase, protein; Motility/polarity/chemotaxis; Protein kinase, Ser/Thr (non-receptor); Protein kinase, atypical P42345 2475 1p36.22 human S1261-p 458285 PMKKLHVsTINLQKA phosphorylation cell growth, induced; apoptosis, inhibited; signaling pathway regulation 19487463; 21576368; 34418433 5 29 5 +Bcl11b Bcl-11B C2H2-type zinc finger protein; Nuclear receptor co-regulator; Transcription regulation Q99PV8 58208 12 F1|12 59.1 cM mouse S318-p 4772870 PGTPPLFsPPPRHHL molecular association, regulation SENP1(INDUCES) 22700985 0 6 27 +KDM1A LSD1 DEMETHYLASE; Demethylase; EC 1.-.-.-; Nuclear receptor co-regulator; Oxidoreductase; Transcription factor O60341 23028 1p36.12 human S131-p 453104 DESLANLsEDEYYSE molecular association, regulation; ubiquitination; intracellular localization cell growth, induced RNF168(INDUCES) 25999347 1 50 262 recruited to sites of DNA damage, promotes the interaction between 53BP1 and RNF168 in chromatin, RNF168-dependent 53BP1 ubiquitination +Tigit TIGIT Cell surface; Membrane protein, integral P86176 100043314 16|16 B4 mouse Y236-p 33668513 EYFNVLSyRSLESFI molecular association, regulation SHIP(DISRUPTS) 24817116 1 0 0 +SSH1 SSH1 EC 3.1.3.16; EC 3.1.3.48; PHOSPHATASE; Protein phosphatase, dual-specificity Q8WYL5 54434 12q24.11 human S937-p 455274 SNLTRSSsSDSIHSV molecular association, regulation; intracellular localization; activity, inhibited cell motility, altered 14-3-3 beta(INDUCES) 15159416; 19567672; 21525957 3 25 13 +NDUFS4 NDUFS4 EC 1.6.5.3; EC 1.6.99.3; Energy Metabolism - oxidative phosphorylation; Mitochondrial; Oxidoreductase O43181 4724 5q11.2 human S173-p 2103602 WNKRTRVsTK_____ intracellular localization 18291624 3 1 0 +SPAG5 SPAG5 Cell cycle regulation Q96R06 10615 17q11.2 human T937-p 460416 ADEEPEStPVPLLGS intracellular localization 18055457 1 1 0 required for SPAG5 localization to the spindle apparatus during mitosis +Nos1 nNOS Amino Acid Metabolism - arginine and proline; EC 1.14.13.39; Oxidoreductase P29476 24598 12q16 rat K24-ac 2459103 SVRLFKRkVGGLGFL PDZ activity, induced 18415985 1 1 0 +Mef2d MEF2D DNA-binding; Transcription factor O89038 81518 2q34 rat S149-p 10359103 MPVTVPVsNQSSMQF HJURP_C activity, inhibited apoptosis, altered; transcription, inhibited 19801631 1 0 0 +PTS PTS Cofactor and Vitamin Metabolism - folate biosynthesis; EC 4.2.3.12; Lyase; Mitochondrial Q03393 5805 11q23.1 human S19-p 450662 AQVSRRIsFSASHRL PTPS enzymatic activity, induced 10531334 1 19 1 +NCOA2 SRC-2 Motility/polarity/chemotaxis; Nuclear receptor co-regulator; Transcription, coactivator/corepressor Q15596 10499 8q13.3 human S499-p 4728850 MSPGVAGsPRIPPSQ NCOA_u2 transcription, induced 22158970 2 19 0 +NDC80 HEC1 Cell cycle regulation O14777 10403 18p11.32 human S165-p 449867 LGYPFALsKSSMYTV Ndc80_HEC molecular association, regulation cell cycle regulation; cell growth, induced NEK2(INDUCES) 12386167; 18297113; 21832156; 24662830 6 0 0 +CAMK2B CAMK2B EC 2.7.11.17; KINASE; Kinase, protein; Protein kinase, CAMK; Protein kinase, Ser/Thr (non-receptor) Q13554 816 7p13 human T287-p 450048 SMMHRQEtVECLKKF cell motility, induced; cell adhesion, induced; cytoskeletal reorganization 35396220 32 17 109 +Myc Myc DNA-binding; Nucleolus; Oncoprotein; Transcription factor P01108 17869 15 D1|15 26.19 cM mouse T415-p 450962 VVILKKAtAYILSIQ HLH molecular association, regulation; activity, inhibited cell cycle regulation; apoptosis, inhibited; transcription, altered; transcription, inhibited; cell growth, altered MAX(DISRUPTS) 14749374; 20043278 6 0 0 mutation of this site enhances epidermal differentiation +CDK5 CDK5 Cell cycle regulation; EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, CMGC; Protein kinase, Ser/Thr (non-receptor) Q00535 1020 7q36.1 human Y15-p 448022 EKIGEGTyGTVFKAK Pkinase phosphorylation 20516069 17 47 894 induces phosphorylation of its substrate STAT3 +Kif15 KIF15 Microtubule-binding; Motor Q7TSP2 353302 8q32 rat T1142-p 9299850 EYPQSPKtPPHFQTH molecular association, regulation cell motility, inhibited MYO3B(INDUCES) 27170353 1 11 13 +DSN1 DSN1 Cell cycle regulation Q9H410 79980 20q11.23 human S77-p 3212370 QERLQSKsLHLSPQE intracellular localization 25660545 1 9 1 localization to G1 and G2 kinetochores +Glp1r GLP1R GPCR, family 2; Membrane protein, integral; Membrane protein, multi-pass; Receptor, GPCR P32301 25051 20p12 rat S431-p 451366 RLNIQRDsSMKPLKC receptor desensitization, altered 8702711 1 0 0 +HNRNPA1 hnRNP A1 Nuclear export; RNA splicing; RNA-binding; Spliceosome P09651 3178 12q13.13 human K113-sm 2894418 KIFVGGIkEDTEEHH RRM_1 sumoylation; molecular association, regulation carcinogenesis, induced LRSAM1(INDUCES) 33661764; 35579947 3 4 0 SUMOylation induced extracellular vesicle-packaged-hnRNPA1 promoting lymphangiogenesis and LN metastasis; ELNAT1 was packaged into BCa cell?secreted EVs by UBC9-induced sumoylation, EV-mediated ELNAT1?induced LN metastasis +Cpt1a CPT1A EC 2.3.1.21; Lipid Metabolism - fatty acid; Membrane protein, integral; Membrane protein, multi-pass; Mitochondrial; Transferase P32198 25757 1q42 rat S741-p 479870 FHISSKFsSPETDSH Carn_acyltransf enzymatic activity, induced 15247243 1 1 0 in vitro +PTPN11 SHP-2 EC 3.1.3.48; Motility/polarity/chemotaxis; PHOSPHATASE; Protein phosphatase, tyrosine (non-receptor) Q06124 5781 12q24.13 human Y542-p 448492 SKRKGHEyTNIKYSL molecular association, regulation; enzymatic activity, induced carcinogenesis, induced; carcinogenesis, inhibited; cell adhesion, induced; transcription, induced; transcription, altered; cell growth, induced; cell motility, altered; apoptosis, inhibited; cell adhesion, altered; cytoskeletal reorganization GRB2(NOT_REPORTED); GRB2(INDUCES); SHP-2(INDUCES) 11684012; 12531430; 16250012; 17483340; 20855525; 32076487; 34301842; 34657149; 34692535; 37330581; 8041791 38 25 442 +BUB3 BUB3 Cell cycle regulation O43684 9184 10q26.13 human S135-p 1876205008 PCNAGTFsQPEKVYT molecular association, regulation; ubiquitination; phosphorylation; enzymatic activity, induced cell cycle regulation; DNA repair, induced; carcinogenesis, inhibited; chromatin organization, altered; transcription, altered DNAPK(INDUCES); ZNF207(DISRUPTS); CDC20(INDUCES); APC(INDUCES); BUB1(INDUCES); Ku80(INDUCES); Ku70(INDUCES) 35085551 1 0 0 inhibits cyclin B1 ubiquitination, induces H2A phosphorylation +EEF1A1 EEF1A1 Nucleolus; Translation; Translation elongation P68104 1915 6q13 human K165-m2 3898709 TEPPYSQkRYEEIVK GTP_EFTU molecular association, regulation translation, altered L3MBTL iso4(INDUCES); EEF1D(DISRUPTS); eEF1B(DISRUPTS); EEF1G(DISRUPTS) 23583077; 28108655 1 7 12 +PRKD1 PRKD1 Autophagy; EC 2.7.11.13; KINASE; Kinase, protein; Motility/polarity/chemotaxis; Protein kinase, CAMK; Protein kinase, Ser/Thr (non-receptor) Q15139 5587 14q12 human S742-p 448590 GEKSFRRsVVGTPAY Pkinase molecular association, regulation; ubiquitination; enzymatic activity, inhibited; enzymatic activity, induced cell cycle regulation; cell differentiation, altered; cell growth, induced; cell motility, altered; signaling pathway regulation; transcription, altered ASK1(INDUCES); IKKB(INDUCES); PKCD(INDUCES); JNK1(INDUCES) 11948398; 15024053; 15226414; 15755722; 16891660; 18337243; 19029298; 21285358; 34010649 56 49 53 inhibits ubiquitination and induces stability of Cyclin B1; PKD-MFF signaling +Pak1 PAK1 EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, STE; Protein kinase, Ser/Thr (non-receptor) P35465 29431 1q32 rat S144-p 448170 SNSQKYMsFTDKSAE enzymatic activity, induced 11278486 24 28 138 +Tbx21 TBX21 DNA-binding; Transcription factor Q9JKD8 57765 11|11 D mouse S224-p 64227003 RLYVHPDsPNTGAHW T-box transcription, induced 28424242 1 1 0 induce IFN-gamma expression +MLH1 MLH1 Cell cycle regulation; DNA repair, damage; Tumor suppressor P40692 4292 3p22.2 human K241-ub 1878089100 EDKTLAFkMNGYISN molecular association, regulation MSH2(INDUCES); MSH6(INDUCES) 30770470 1 1 0 +Tp53 p53 Activator; DNA-binding; Motility/polarity/chemotaxis; Nuclear receptor co-regulator; Transcription factor; Tumor suppressor P02340 22059 11 B3|11 42.83 cM mouse S23-p 447529 PLSQETFsGLWKLLP P53_TAD activity, induced; molecular association, regulation; protein stabilization cell cycle regulation; apoptosis, altered; transcription, inhibited; cell growth, altered MDM2(DISRUPTS) 12356735; 15343266; 16757976; 20818388 127 2 0 +MAPT Tau iso8 ACETYLTRANSFERASE; Acetyltransferase; Cytoskeletal P10636-8 4137 17q21.31 human T205-p 447933 SSPGSPGtPGSRSRT O-GlcNAc glycosylation; molecular association, regulation; intracellular localization; protein conformation; phosphorylation cytoskeletal reorganization ubiquitin(INDUCES); Tau iso8(INDUCES) 12414518; 14761950; 15190058; 15364924; 18725412; 19451179; 20550628; 26161867; 31543505; 33952699; 35298090; 35610289; 35857446; 37488165 142 27 26 +HSF1 HSF1 DNA-binding; Transcription factor Q00613 3297 8q24.3 human T142-p 449066 DSVTKLLtDVQLMKG activity, induced; molecular association, regulation transcription, altered HSF1(INDUCES) 12659875; 35080342 4 1 0 +TBK1 TBK1 EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, Other; Protein kinase, Ser/Thr (non-receptor) Q9UHD2 29110 12q14.2 human K241-ac 56403910 MYKIITGkPSGAISG Pkinase molecular association, regulation; intracellular localization; enzymatic activity, inhibited IRF3(INDUCES) 32772249 2 2 0 recruitment of IRF3 to TBK1 +Ranbp2 RANBP2 Adaptor/scaffold; EC 5.2.1.8; EC 6.3.2.-; Ligase; Nuclear export; Nucleoporin; SUMO LIGASE; SUMO conjugating system; SUMO ligase Q9ERU9 19386 10 B4|10 29.34 cM mouse S3036-p 12667488 RKIESFGsPKGSVSR Pro_isomerase enzymatic activity, inhibited 24403063 1 27 1 +SYK Syk EC 2.7.10.2; KINASE; Kinase, protein; Protein kinase, TK; Protein kinase, tyrosine (non-receptor) P43405 6850 9q22.2 human S295-p 7445408 GIISRIKsYSFPKPG protein degradation; ubiquitination cell cycle regulation; carcinogenesis, induced 22585575 2 4 12 +UBE3A UBE3A iso2 EC 6.3.2.-; EC 6.3.2.19; Ligase; Nuclear receptor co-regulator; Transcription, coactivator/corepressor; UBIQUITIN LIGASE; Ubiquitin conjugating system; Ubiquitin ligase Q05086-2 7337 15q11.2 human Y636-p 50838700 GDSHPVLyQSLKDLL HECT protein stabilization; enzymatic activity, inhibited; protein conformation 23581475 1 1 0 oligomerization of UBE3A, Abl protects p53 from HPV-E6?E6AP complex-mediated degradation by phosphorylating E6AP +EZR Ezrin Cytoskeletal; Motility/polarity/chemotaxis P15311 7430 6q25.3 human Y146-p 448758 KEVHKSGyLSSERLI FERM_M molecular association, regulation; intracellular localization; phosphorylation carcinogenesis, induced; cell motility, induced; cell motility, altered; cytoskeletal reorganization; cell adhesion, altered; cell growth, altered EGFR(INDUCES) 15647376; 24385580; 26936397; 37328063; 9230083 16 2 2 +Etv5 ERM DNA-binding; Transcription factor Q9CXC9 104156 16|16 B1 mouse S367-p 451201 PPYQRRGsLQLWQFL transcription, induced 33219327 2 0 0 induced Cxcl5 and Cxcl12 transcription +MYOCD myocardin Cell development/differentiation; Transcription factor Q8IZQ8 93649 17p12 human K571-sm 3144811 PFLAASIkQEEAVSS transcription, induced 17101795 1 0 0 +ID2 ID2 DNA-binding; Transcription, coactivator/corepressor Q02363 3398 2p25.1 human S14-p 4706868 VRSVRKNsLSDHSLG protein stabilization cell growth, inhibited 26756672 3 16 0 +KAT7 MYST2 ACETYLTRANSFERASE; Acetyltransferase; EC 2.3.1.48; Nuclear receptor co-regulator; Transcription, coactivator/corepressor O95251 11143 17q21.33 human K338-ub 22248096 TEGSNMIkTIAFGRY zf-MYST protein degradation; acetylation cell growth, inhibited 23319590 1 1 0 H3K14 acetylation is reduced +PLD2 PLD2 EC 3.1.4.4; Lipid Metabolism - ether lipid; Lipid Metabolism - glycerophospholipid; Motility/polarity/chemotaxis; Phospholipase O14939 5338 17p13.2 human S243-p 456497 RWLVVKDsFLLYMCL enzymatic activity, induced 15979581 1 1 0 +RAB34 RAB34 G protein, monomeric; G protein, monomeric, Rab; Nucleolus Q9BZG1 83871 17q11.2 human Y247-p 455172 NSDDSNLyLTASKKK endocytosis, induced; cell motility, induced; cell adhesion, induced 29622794 1 15 107 enhances integrin beta-3 endocytosis and recycling; cell migration and invasion +DCLRE1C Artemis DNA repair, damage; Deoxyribonuclease; EC 3.1.-.- Q96SD1 64421 10p13 human S647-p 38410204 STNADSQsSSDFEVP molecular association, regulation; intracellular localization DNA repair, induced PAXIP1(INDUCES) 25512557 1 1 0 Artemis prevents end resection and promotes non-homologous end joining +SREBF1 SREBP-1 iso3 DNA-binding; Membrane protein, integral; Membrane protein, multi-pass; Transcription factor P36956-3 6720 17p11.2 human T402-p 467200 TEVEDTLtPPPSDAG transcription, induced 25353341 6 3 0 mRNA expression of central SREBP-1 target genes; Phosphorylation interferes with lipid metabolism and the secretory activity of liver cells. +NFATC2IP NFATC2IP Transcription, coactivator/corepressor Q8NCF5 84901 16p11.2 human S204-p 3206613 NSPLSPPsPRTKSRT activity, induced; molecular association, regulation carcinogenesis, induced; cell motility, induced; transcription, induced NFAT1(INDUCES) 34265397 1 41 1 +GATA3 GATA3 Transcription factor P23771 2625 10p14 human K346-ac 460637 NACGLYYkLHNINRP GATA intracellular localization cell growth, inhibited; transcription, induced 10970860 1 0 0 regulated survival after activation, regulates T-cell trafficking to secondary +TRAF3 TRAF3 UBIQUITIN LIGASE; Ubiquitin conjugating system; Ubiquitin ligase Q13114 7187 14q32.32 human K429-ub 1877126904 IRDYKRRkQEAVMGK molecular association, regulation; intracellular localization transcription, altered MAVS(INDUCES); TBK1(INDUCES) 32324863 1 1 0 TRIM24-mediated antiviral immunity, VSV-induced interaction of TRAF3 with MAVS and TBK1 +LLGL2 LLGL2 Cell cycle regulation Q6P1M3 3993 17q25.1 human S653-p 13197200 LKKSLRQsFRRMRRS intracellular localization 12725730 1 16 2 localization to cell periiphery and regulation of cell polarization +NEDD1 NEDD1 Cell cycle regulation Q8NHV4 121441 12q23.1 human S557-p 25533019 TPNPKIAsSVTAGVA molecular association, regulation cytoskeletal reorganization TUBG1(INDUCES) 22595525 1 1 0 regulates spindle assembly in mitosis; Negative effect on NEDD1 function +F11r JAM-A Cell adhesion; Membrane protein, integral O88792 16456 1 H3|1 79.43 cM mouse S285-p 467829 KVIYSQPsTRSEGEF activity, induced; protein stabilization; intracellular localization cytoskeletal reorganization 22371556; 28062807; 30723104 5 51 19 required for formation of functional tight junctions; Induce Trans-epithelial electrical resistance (TER) increase and regulates biliary epithelial barrier function +Nyap2 NYAP2 Cell development/differentiation Q8BM65 241134 1|1 C5 mouse Y277-p 455101 PEEEEPVyIEMVGNI NYAP_N molecular association, regulation PIK3R1(INDUCES) 21946561 1 1 48 localization to the neuronal plasma membrane, interaction with WAVE complex +EXO1 EXO1 EC 3.1.-.-; Hydrolase Q9UQ84 9156 1q43 human S714-p 482301 CNIKLLDsQSDQTSK protein degradation 18048416 2 4 3 +XBP1 XBP1 DNA-binding; Transcription factor P17861 7494 22q12.1|22q12 human S181-p 27523600 QQVQAQLsPLQNISP protein degradation; molecular association, regulation; intracellular localization FOXO1A(INDUCES) 23277279 1 0 0 +TCF3 E2A iso2 Cell development/differentiation; DNA-binding; Oncoprotein; Transcription factor P15923-2 6929 19p13.3 human T355-p 455166 NFSSSPStPVGSPQG molecular association, regulation transcription, induced NEUROD1(INDUCES) 12810726 3 4 25 +PML PML Nucleolus; Oncoprotein; SUMO LIGASE; SUMO conjugating system; SUMO ligase; Transcription factor; Tumor suppressor; Ubiquitin conjugating system P29590 5371 15q24.1 human S38-p 451470 EGRQPSPsPSPTERA sumoylation apoptosis, altered 19015637 2 11 0 induces sumoylation +Spred1 SPRED1 Inhibitor Q924S8 114715 2|2 E5 mouse Y420-p 18899302 IVPCMCCyVPLRMCH Sprouty cell differentiation, altered; signaling pathway regulation 21531714 1 0 0 inhibits the Ras/ERK pathway +Map3k12 DLK EC 2.7.11.25; KINASE; Kinase, protein; Protein kinase, Ser/Thr (non-receptor); Protein kinase, TKL Q60700 26404 15|15 F3 mouse K271-ub 1881852000 KIIHRDLkSPNMLIT protein degradation; enzymatic activity, inhibited 35101451 1 0 0 Fkbp8 delayed axon degeneration in mouse sciatic nerves, competition between ubiquitination and SUMOylation +LMO2 LMO2 Adaptor/scaffold; Oncoprotein P25791 4005 11p13 human K74-ac 1875199600 VGRRLYYkLGRKLCR LIM molecular association, regulation; activity, inhibited cell differentiation, inhibited; cell growth, inhibited; apoptosis, induced; transcription, inhibited LDB1(DISRUPTS) 31366618 1 0 0 inactivation of TAL-1 complex, LMO2 is deacetylated by PBEF/SIRT2 during the early stages of hematopoietic differentiation +TP53 p53 Activator; DNA-binding; Motility/polarity/chemotaxis; Nuclear receptor co-regulator; Transcription factor; Tumor suppressor P04637 7157 17p13.1 human T211-p 25535400 EYLDDRNtFRHSVVV P53 protein degradation; ubiquitination cell cycle regulation; carcinogenesis, induced; apoptosis, inhibited; transcription, inhibited 22611192 1 0 0 +TNFRSF1A TNF-R1 Membrane protein, integral; Receptor, cytokine P19438 7132 12p13.31 human Y401-p 455157 RCLREAQySMLATWR Death transcription, induced 21724995 1 0 6 +JUN Jun Oncoprotein; Transcription factor P05412 3725 1p32.1 human T95-p 1988300 ITTTPTPtQFLCPKN Jun activity, induced apoptosis, altered; transcription, altered 17920329 1 2 0 required for c-Jun mediated cell death; regulates transcription by controlling T91/T93 phosphorylation +Cacng2 Stargazin Channel, calcium; Membrane protein, integral; Membrane protein, multi-pass O88602 12300 15 E1|15 36.92 cM mouse T321-p 451273 NTANRRTtPV_____ molecular association, regulation PSD-93(DISRUPTS) 11805122 3 0 0 +RELA NFkB-p65 DNA-binding; Nuclear receptor co-regulator; Transcription factor Q04206 5970 11q13.1 human K221-me 31094533 LLCDKVQkEDIEVYF RHD_dimer molecular association, regulation transcription, induced DNA(INDUCES) 23904479 1 0 0 +PNCK CAMK1B EC 2.7.11.17; KINASE; Kinase, protein; Protein kinase, CAMK; Protein kinase, Ser/Thr (non-receptor) Q6P2M8 139728 Xq28 human T171-p 18637400 QAGNMLGtACGTPGY Pkinase enzymatic activity, inhibited; enzymatic activity, induced signaling pathway regulation 21325639; 24552815 2 0 1 ERK1/2, MAPK activity inhibited +KCNH2 Kv11.1 iso5 Channel, potassium; Membrane protein, integral; Membrane protein, multi-pass; Motility/polarity/chemotaxis Q12809_VAR_014388 3757 7q36.1 human T897-p 4839200 SFRRRTDtDTEQPGE activity, inhibited 18791070 1 1 2 reduces basal channel current amplitude +CHEK2 Chk2 EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, CAMK; Protein kinase, Ser/Thr (non-receptor); Tumor suppressor O96017 11200 22q12.1 human T378-p 981402 HSKILGEtSLMRTLC Pkinase intracellular localization 20713355 2 3 1 chromatin targeting of S372, S379, T389, singly and T383/389, T378/S379 +JAK2 JAK2 EC 2.7.10.2; KINASE; Kinase, protein; Oncoprotein; Protein kinase, TK; Protein kinase, tyrosine (non-receptor) O60674 3717 9p24.1 human K630-sm 31899103 ILVQEFVkFGSLDTY PK_Tyr_Ser-Thr molecular association, regulation; intracellular localization GH receptor(DISRUPTS) 23581279 1 0 0 translocation into the nucleus +Rem2 REM2 G protein; G protein, monomeric; G protein, monomeric, RGK Q8VEL9 140743 14|14 C2 mouse S332-p 1211204 AKFFKQRsRSCHDLS molecular association, regulation; intracellular localization 14-3-3 beta(DISRUPTS) 17605760 1 0 0 +MZF1 MZF-1 C2H2-type zinc finger protein; DNA-binding; Transcription factor P28698 7593 19q13.43 human S453-p 1868832802 GQSFRQRsNLLQHQR zf-C2H2 carcinogenesis, altered 31301870 1 0 0 alters cancer cell stemness +STING1 STING Apoptosis; Endoplasmic reticulum; Membrane protein, integral; Membrane protein, multi-pass; Mitochondrial Q86WV6 340061 5q31.2 human K338-ub 964547960 RHLRQEEkEEVTVGS protein degradation 35871231 1 1 0 UFL1 reduces STING ubiquitination +PPP1R13L PPP1R13L Apoptosis; Phosphatase, regulatory subunit; Transcription, coactivator/corepressor Q8WUF5 10848 19q13.32 human S84-p 5197296 EPFGSRGsPRKAATD molecular association, regulation; intracellular localization; protein conformation cell growth, inhibited p53(INDUCES); PPP1R13L(DISRUPTS) 23623661; 30105797 2 6 2 miR-129 inhibits phosphorylation, blocks nuclear localization and inhibits cell proliferation, p53 and TAp63 levels increased, inhibiting proliferation of Burkitt lymphoma cells; prevents N- and C-terminal self interaction, enhances binding to p53 +Vangl2 VANGL2 Adaptor/scaffold; Membrane protein, integral; Membrane protein, multi-pass Q91ZD4 93840 1 H3|1 79.54 cM mouse S82-p 18460400 VTGTSEHsISHDDLT Strabismus activity, induced; protein stabilization 21316585 1 1 0 +RRN3 TIF1A Nucleolus; Transcription initiation complex Q9NYV6 54700 16p13.11 human T200-p 455599 IARYVPStPWFLMPI RRN3 molecular association, regulation; intracellular localization; activity, inhibited transcription, inhibited TAF1B(DISRUPTS); POLR1B(DISRUPTS) 15805466 1 0 0 +Clock CLOCK ACETYLTRANSFERASE; Acetyltransferase; DNA-binding; EC 2.3.1.48; Transcription factor O08785 12753 5 C3.3|5 40.63 cM mouse S38-p 3927522 KDKAKRVsRNKSEKK HLH protein degradation; intracellular localization transcription, inhibited DNA(DISRUPTS) 19414601 1 1 0 inhibits transcription +RUNX1 AML1 DNA-binding; Oncoprotein; Transcription factor Q01196 861 21q22.12 human K167-ub 95155311 ATYHRAIkITVDGPR Runt protein degradation; intracellular localization carcinogenesis, inhibited; cell growth, inhibited; transcription, inhibited 28536267 1 1 0 +ZNF282 ZNF282 C2H2-type zinc finger protein Q9UDV7 8427 7q36.1 human K369-sm 31094512 HDILSWIkQEEQPYP molecular association, regulation carcinogenesis, induced; transcription, induced CALCOCO1(INDUCES); ER-alpha(INDUCES) 22986521 1 1 0 +RRM2 RRM2 EC 1.17.4.1; Nucleotide Metabolism - purine; Nucleotide Metabolism - pyrimidine; Other Amino Acids Metabolism - glutathione; Oxidoreductase P31350 6241 2p25.1 human K95-ac 1878237800 HDIWQMYkKAEASFW molecular association, regulation cell cycle regulation; cell growth, inhibited RRM2(INDUCES) 31324785 1 1 0 K95 disrupts its homodimerization, RRM2 is deacetylated following DNA damage +MCM4 MCM4 DNA replication; EC 3.6.4.12 P33991 4173 8q11.21 human K216-m1 58123003 NVNCEHIkSFDKNLY MCM_N molecular association, regulation L3MBTL iso4(INDUCES) 23583077 0 1 0 +CTNND1 CTNND1 Actin-binding; Adaptor/scaffold; Cell adhesion; G protein regulator, misc.; Motility/polarity/chemotaxis O60716 1500 11q12.1 human S268-p 450453 PQVRVGGsSVDLHRF activity, induced; protein stabilization; molecular association, regulation carcinogenesis, induced; endocytosis, induced; cell motility, induced; transcription, induced; cell adhesion, inhibited CDH2(DISRUPTS); LRP5(DISRUPTS); LRP6(DISRUPTS) 24412065; 32589661 12 73 56 +GCK GK Carbohydrate Metabolism - amino sugar and nucleotide sugar; Carbohydrate Metabolism - galactose; Carbohydrate Metabolism - glycolysis and gluconeogenesis; Carbohydrate Metabolism - starch and sucrose; EC 2.7.1.2; Kinase, other; Mitochondrial P35557 2645 7p13 human K414-sm 27581520 GVDGSVYkLHPSFKE Hexokinase_2 protein stabilization; enzymatic activity, induced 23297408 1 1 0 +CERS5 LASS5 DNA-binding; EC 2.3.1.24; Membrane protein, integral; Membrane protein, multi-pass; Transferase Q8N5B7 91012 12q13.12 human S355-p 18260885 DRSDVESsSEEEDVT enzymatic activity, induced 26887952 1 6 0 +Csf3r GCSFR Membrane protein, integral; Receptor, cytokine P40223 12986 4 D2.2|4 59.77 cM mouse Y728-p 451101 LPALVQAyVLQGDPR activity, induced; molecular association, regulation cell differentiation, altered; transcription, induced; signaling pathway regulation 29572350; 30679703; 7489718 4 0 0 Receptors mutant for Y728 or Y753 could neither transduce growth-inhibitory signals nor induce the neutrophil-specific myeloperoxidase (MPO) gene. A Y728 mutant did not induce morphological changes in cells.; STAT3 activation; regulates ERK1/2 pathway +TRAF3 TRAF3 UBIQUITIN LIGASE; Ubiquitin conjugating system; Ubiquitin ligase Q13114 7187 14q32.32 human S9-p 5274284 ESSKKMDsPGALQTN cell growth, induced; apoptosis, inhibited; transcription, induced; signaling pathway regulation 34255829 0 9 1 induces NIK stabilization and NF-kB signaling +TRPM8 TRPM8 Channel, cation; Membrane protein, integral; Membrane protein, multi-pass Q7Z2W7 79054 2q37.1 human K423-ub 1881122800 FSTSEQDkDNWNGQL ubiquitination; intracellular localization 33037615 1 0 0 reduces TRPM8 on cell surface, and reduces channel currents +SLCO1B1 SLCO1B1 Membrane protein, integral; Membrane protein, multi-pass; Transporter; Transporter, SLC family Q9Y6L6 10599 12p12.1 human Y645-p 13831749 VLYIILIyAMKKKYQ TM activity, induced 33664059 1 2 0 +VIL1 Villin Actin-binding; Motility/polarity/chemotaxis P09327 7429 2q35 human Y46-p 469582 SFFDGDCyIILAIHK Gelsolin cytoskeletal reorganization 12269817 2 0 1 +SSB SSB Transcription initiation complex P05455 6741 2q31.1 human K200-sm 55544702 NEERKQNkVEAKLRA molecular association, regulation RNA(INDUCES) 27224031 1 0 0 No difference in CK2-dependent SSB phosphorylation at S366 in K41R/200R mutant and WT +ADRB2 ADRB2 GPCR, family 1; Membrane protein, integral; Membrane protein, multi-pass; Receptor, GPCR P07550 154 5q32 human Y308-p 33638000 NLIRKEVyILLNWIG 7tm_1; TM signaling pathway regulation 24831005 1 0 0 induces Gs-protein-biased signaling of ADRB2 adreoceptor +kif2c KIF2C Cancer Testis Antigen (CTA); Microtubule-binding; Motility/polarity/chemotaxis; Motor Q91636 380006 frog T95-p 451107 SQNHKRKtISKIPAP molecular association, regulation; intracellular localization cytoskeletal reorganization DNA(DISRUPTS) 17567953 5 4 3 +GRIN2B NMDAR2B Channel, calcium; Channel, ligand-gated; Membrane protein, integral; Membrane protein, multi-pass Q13224 2904 12p13.1 human Y1474-p 448167 GSSNGHVyEKLSSIE NMDAR2_C carcinogenesis, induced; cell motility, induced 36139568 42 1 104 +Ahcyl1 AHCYL1 Amino Acid Metabolism - cysteine and methionine; EC 3.3.1.1; Hydrolase; Other Amino Acids Metabolism - selenoamino acid Q80SW1 229709 3 F2.3|3 46.83 cM mouse S84-p 456615 SAASYTDsSDDEVSP molecular association, regulation PIP5K1A(INDUCES) 26509711 1 3 4 +BDKRB2 BKR2 GPCR, family 1; Membrane protein, integral; Membrane protein, multi-pass; Receptor, GPCR P30411 624 14q32.2 human S373-p 447664 SMGTLRTsISVERQI receptor desensitization, altered 11517230 2 2 0 +HSPA5 GRP78 Chaperone; Heat shock protein; KINASE P11021 3309 9q33.3 human K122-ac 3692107 LPFKVVEkKTKPYIQ HSP70 molecular association, regulation; phosphorylation apoptosis, induced; signaling pathway regulation PERK(DISRUPTS) 20371724 1 2 1 induces phosphorylation of elf2a and activation of eIf2a-ATF4-CHOP pathway +MYBL2 B-Myb DNA-binding; Motility/polarity/chemotaxis; Transcription factor P10244 4605 20q13.12 human T515-p 450110 QKYSMDNtPHTPTPF Cmyb_C molecular association, regulation; protein conformation transcription, induced DNA(INDUCES) 35926712 2 1 0 +Blk BLK EC 2.7.10.2; KINASE; Kinase, protein; Protein kinase, TK; Protein kinase, tyrosine (non-receptor) P16277 12143 14 D1|14 33.25 cM mouse Y495-p 447607 YTATEGQyELQP___ protein stabilization; enzymatic activity, inhibited cell growth, altered 10449731; 9636152 2 1 19 Constitutively active mutant developed lymphomas. Tyrosine phosphorylated proteins such as PLC-gamma and PI3K, were seen in tumors. +TRIM24 TRIM24 EC 2.3.2.27; KINASE; Kinase, protein; Nuclear receptor co-regulator; Protein kinase, atypical; Transcription, coactivator/corepressor; Tumor suppressor; UBIQUITIN LIGASE; Ubiquitin conjugating system; Ubiquitin ligase O15164 8805 7q33-q34 human S808-p 3174917 KSEWLDPsQKSPLHV molecular association, regulation; phosphorylation DNA repair, induced MRE11A(INDUCES) DNA(INDUCES) 36550358 1 14 0 induces H2AX phosphorylation +RCC1 RCC1 Cell cycle regulation; GEF; GEF, Ras P18754 1104 1p35.3 human S20-p 2850003 PADAIPKsKKVKVSH molecular association, regulation KPNA4(DISRUPTS) 18568422 1 1 0 +CLASP2 CLASP2 Cytoskeletal; Motility/polarity/chemotaxis O75122 23122 3p22.3 human S541-p 24976300 RESSRDTsPVRSFQP cytoskeletal reorganization 22467876 2 5 0 +MOB1B MOB1B Activator; Protein kinase, regulatory subunit Q7L9L4 92597 4q13.3 human T12-p 3545000 FGSRSSKtFKPKKNI molecular association, regulation; phosphorylation cell cycle regulation; cell growth, altered NDR1(INDUCES); NDR2(INDUCES); LATS1(INDUCES); LATS2(INDUCES) 18328708; 19919647 3 1 3 +NR4A1 Nur77 Apoptosis; DNA-binding; Nuclear receptor P22736 3164 12q13.13 human T55-p 41583609 TALPSFStFMDGYTG cell motility, induced; cell growth, induced; cytoskeletal reorganization 26155943 1 0 0 required for increase in cell growth, cell motility, monolayer permeability, and formation of actin stress fibers. +LHX3 LHX3 DNA-binding; Transcription factor Q9UBR4 8022 9q34.3 human T63-p 455294 LKCSDCHtPLAERCF LIM activity, induced transcription, induced 15517599 1 0 0 no change in binding to DNA or to certain proteins (NLI, PIT1, or MRG1) +RPS6KB1 p70S6K EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, AGC; Protein kinase, Ser/Thr (non-receptor); Translation P23443 6198 17q23.1 human S427-p 450014 ESVKEKFsFEPKIRS enzymatic activity, induced 7489717; 7545671 5 13 0 +Msi1 Musashi-1 RNA-binding Q61474 17690 5|5 F mouse S337-p 40638600 SSYISAAsPAPSTGF cell differentiation, induced; translation, induced 25888190 1 0 0 +Ikbkb IKKB EC 2.7.11.10; KINASE; Kinase, protein; Protein kinase, Other; Protein kinase, Ser/Thr (non-receptor) O88351 16150 8|8 A2 mouse S692-p 5735033 GQLMSQPsSACDSLP molecular association, regulation; phosphorylation PPP2R3C(INDUCES) 20925653 1 0 0 interaction with PPP2R3C (aka G4-1) downregulates IKK-beta activity; S181 phosphorylation increased in S679/682/689/692/697/701/705A mutant +Notch1 Notch 1 Membrane protein, integral; Motility/polarity/chemotaxis; Oncoprotein; Receptor, misc.; Transcription factor Q01705 18128 2 A3|2 18.91 cM mouse K2150-ac 18899502 TQGKKARkPSTKGLA protein stabilization; ubiquitination 21499261 2 1 0 +Bcar1 P130Cas Adaptor/scaffold; Motility/polarity/chemotaxis Q63767 25414 19q12 rat Y764-p 448400 GWMEDYDyVHLQGKE CAS_C molecular association, regulation Fyn(INDUCES) 9360983 2 3 23 +Bag3 BAG3 Apoptosis; Chaperone Q9JLV1 29810 7|7 F3 mouse S297-p 467532 GTPVHCPsPIRVHTV protein degradation neural plasticity 31955914 2 40 27 +POU2AF1 POU2AF1 Oncoprotein; Transcription, coactivator/corepressor Q16633 5450 11q23.1 human S184-p 10239701 FPWPQPLsTLPTSTL PD-C2-AF1 transcription, induced 9211847 1 0 0 +Mtss1 MTSS1 Adaptor/scaffold; Motility/polarity/chemotaxis; Tumor suppressor Q8R1S4 211401 15|15 D1 mouse Y398-p 473757 LPDYAHYyTIGPGMF cytoskeletal reorganization 17224454 1 0 3 +Bik BIK Apoptosis; Membrane protein, integral; Mitochondrial O70337 12124 15|15 E1 mouse K33-ub 25171000 ASETPSMkEPVRDVD bcl-2I13 protein degradation 22388352 1 0 0 +TP53 p53 Activator; DNA-binding; Motility/polarity/chemotaxis; Nuclear receptor co-regulator; Transcription factor; Tumor suppressor P04637 7157 17p13.1 human K292-ub 3931323 EEENLRKkGEPHHEL protein degradation; molecular association, regulation cell cycle regulation; cell growth, induced; apoptosis, inhibited; transcription, altered DNA(INDUCES) 19536131; 28362432; 33568778 3 2 5 differential transcription-activation or inhibition at specific promoters +RALBP1 RALBP1 GAP; GAP, Rac/Rho Q15311 10928 18p11.22 human T297-p 3136101 ACGRTTEtEKVQEFQ RhoGAP activity, induced; protein conformation 16087181 1 0 0 +DUSP1 DUSP1 EC 3.1.3.16; EC 3.1.3.48; Motility/polarity/chemotaxis; PHOSPHATASE; Protein phosphatase, dual-specificity P28562 1843 5q35.1 human S296-p 457717 KQRRSIIsPNFSFMG DSPc protein degradation; molecular association, regulation SKP2(INDUCES) 16286470 1 0 0 MKP-1 is a substrate for Skp2 ligase +RYR2 RYR2 Channel, ligand-gated; Membrane protein, integral; Membrane protein, multi-pass; Transporter; Transporter, ion channel Q92736 6262 1q43 human S2808-p 448848 YNRTRRIsQTSQVSV activity, induced 30571258; 35885069 57 5 3 +DBNL DBNL Actin-binding; Motility/polarity/chemotaxis Q9UJU6 28988 7p13 human T291-p 476604 PFLQKQLtQPETHFG molecular association, regulation signaling pathway regulation 14-3-3 beta(INDUCES); 14-3-3 theta(INDUCES); HPK1(INDUCES) 21725060; 36639542 2 43 58 inhibits the MAP4K1/JNK/GPX4 cell death pathway; mutation of this site prevents 14-3-3 binding (pan-14-3-3 antibody) +IFI16 IFI16 Transcription factor Q16666 3428 1q23.1 human K99-ac 35700306 PALSRKRkKEVDATS intracellular localization 22691496 1 1 0 +CDK5R1 CDK5R1 Protein kinase, regulatory subunit Q15078 8851 17q11.2 human Y234-p 900975701 LTCLYLSySYMGNEI CDK5_activator cell adhesion, inhibited PKCD(INDUCES) 29511352 1 0 0 +MAGEA11 MAGE-A11 Cancer Testis Antigen (CTA); Transcription, coactivator/corepressor P43364 4110 Xq28 human S174-p 2028416 ESPSPPQsPQEESFS MAGE_N molecular association, regulation transcription, induced AR(INDUCES) 19828458 2 0 0 stimulates MAGE-A11 interaction with AR and increases its transcriptional activity +Stat3 STAT3 DNA-binding; Motility/polarity/chemotaxis; Nuclear receptor co-regulator; Transcription factor P52631 25125 10q31 rat S727-p 448191 NTIDLPMsPRTLDSL activity, induced; molecular association, regulation; intracellular localization cell differentiation, altered; apoptosis, altered; transcription, induced; transcription, altered SP1(INDUCES) DNA(NOT_REPORTED) 11922392; 15860735; 16048438; 16611639; 19109898; 19427337 227 57 67 +MYL12A MRLC3 Contractile P19105 10627 18p11.31 human T18-p 7382101 KKRPQRAtSNVFAMF protein conformation; enzymatic activity, induced cell cycle regulation; exocytosis, induced; cytoskeletal reorganization 10944522; 15069078; 15753305; 8530442 10 48 239 +TFAP2A AP-2 alpha DNA-binding; Transcription factor P05549 7020 6p24.3 human S429-p 20797701 TDNNAKSsDKEEKHR protein stabilization transcription, induced 21777522 1 0 0 induces AP-2 alpha transcription +BARD1 BARD1 EC 6.3.2.-; EC 6.3.2.19; Ligase; UBIQUITIN LIGASE; Ubiquitin conjugating system; Ubiquitin ligase Q99728 580 2q35 human T734-p 465471 DSDQRFCtQYIIYED RNA stability, altered 16651405 1 0 1 inhibits mRNA processing +MAP3K5 ASK1 EC 2.7.11.25; KINASE; Kinase, protein; Protein kinase, STE; Protein kinase, Ser/Thr (non-receptor) Q99683 4217 6q23.3 human S966-p 447736 NEYLRSIsLPVPVLV molecular association, regulation; enzymatic activity, inhibited; activity, inhibited apoptosis, altered; apoptosis, induced; apoptosis, inhibited; signaling pathway regulation; transcription, altered 14-3-3 beta(INDUCES); 14-3-3 zeta(INDUCES); TXN(INDUCES); 14-3-3 gamma(INDUCES); AIP1(DISRUPTS) 10411906; 14688258; 15094778; 17671211; 18794113; 19004820; 19920149; 24985705; 27514745 17 4 1 +MAN1A1 MAN1A1 Calcium-binding; EC 3.2.1.113; Endoplasmic reticulum; Glycan Metabolism - N-glycan biosynthesis; Hydrolase; Membrane protein, integral P33908 4121 6q22.31 human S12-p 15411997 GLLPLFSsPAGGVLG O-GlcNAc glycosylation; molecular association, regulation; enzymatic activity, inhibited MGAT1(DISRUPTS) 36417860 1 3 1 inhibits glycosylation +ZBTB7B ZBTB7B C2H2-type zinc finger protein O15156 51043 1q21.3 human K360-ac 31077503 KIIHGAGkLPRHMRT protein stabilization transcription, inhibited 23609452 1 0 0 increased production of IFN-gamma +IFNLR1 IL28RA Membrane protein, integral Q8IU57 163702 1p36.11 human K319-ub 1883375201 ATQQTRWkKDLAEDE protein degradation 36379255 1 0 0 +SMARCA4 SMARCA4 Cell cycle regulation; EC 3.6.1.-; EC 3.6.4.-; Helicase; Nuclear receptor co-regulator; Transcription, coactivator/corepressor; Tumor suppressor P51532 6597 19p13.2 human K1029-ac 1878219603 SEKDKKGkGGTKTLM DNA repair, induced; chromatin organization, altered 31291457 1 1 0 recruitment of SIRT1 is required for clearing nucleosomes and promoting HR at DNA DSB sites +GRIN2B NMDAR2B Channel, calcium; Channel, ligand-gated; Membrane protein, integral; Membrane protein, multi-pass Q13224 2904 12p13.1 human Y1252-p 448165 CKKAGNLyDISEDNS NMDAR2_C carcinogenesis, induced; cell motility, induced 36139568 3 0 7 +Gsc GSC DNA-binding; Transcription factor Q02591 14836 12 E|12 54.32 cM mouse K214-sm 2887206 WFKNRRAkWRRQKRS Homeodomain transcription, inhibited 18336814 1 0 0 SUMO modification inhibition is promoter specific +MST1R Ron EC 2.7.10.1; KINASE; Kinase, protein; Membrane protein, integral; Protein kinase, TK; Protein kinase, tyrosine (receptor) Q04912 4486 3p21.31 human Y1239-p 457984 DILDREYySVQQHRH PK_Tyr_Ser-Thr phosphorylation; enzymatic activity, induced cell cycle regulation; carcinogenesis, inhibited; cell growth, inhibited 24739671; 35569509 8 6 121 +TIAM1 TIAM1 GEF; GEF, Rac/Rho; Motility/polarity/chemotaxis; Oncoprotein Q13009 7074 21q22.11 human S231-p 468938 STCQRANsLGDLYAQ protein stabilization; molecular association, regulation 14-3-3 beta(INDUCES) 25746002 2 43 6 +BLVRA BVR Cofactor and Vitamin Metabolism - porphyrin and chlorophyll; EC 1.3.1.24; KINASE; Kinase, protein; Oxidoreductase; Protein kinase, Ser/Thr (non-receptor) P53004 644 7p13 human S21-p 25526801 VGVGRAGsVRMRDLR GFO_IDH_MocA enzymatic activity, induced 22584576 1 1 0 +Camkv VACAMKL KINASE; Kinase, protein; Protein kinase, CAMK; Protein kinase, Ser/Thr (non-receptor) Q3UHL1 235604 9|9 F1 mouse T345-p 60179300 QSASDAAtPGAAGGA activity, inhibited 27796283 1 1 0 dendritic spine maintenance +Lcp1 L-plastin Actin-binding; Motility/polarity/chemotaxis Q61233 18826 14 D3|14 39.63 cM mouse T89-p 3851696 KSTEVAKtFRKAINK intracellular localization cell motility, induced; cytoskeletal reorganization 27465533 1 0 12 lamellipodial formation +SLC12A2 NKCC1 Membrane protein, integral; Membrane protein, multi-pass; Transporter; Transporter, SLC family P55011 6558 5q23.3 human T217-p 455546 LRTFGHNtMDAVPRI AA_permease_N activity, induced 12145304; 12145305 9 22 33 +H3C1 H3 DNA-binding P68431 8350 6p22.2 human R17-me 2584300 STGGKAPrKQLATKA Histone transcription, induced 11747826; 15345777; 16497732 5 0 0 +NDE1 NUDE1 iso1 Cell cycle regulation; Cytoskeletal; Microtubule-binding Q9NXR1-1 54820 16p13.11 human S282-p 469633 RNLVYDQsPNRTGGP NUDE_C molecular association, regulation; intracellular localization ZNF365(DISRUPTS) 16682949 1 32 8 +Ksr1 KSR KINASE; Kinase, protein; Protein kinase, Ser/Thr (non-receptor); Protein kinase, TKL Q61097 16706 11 B5|11 46.74 cM mouse S550-p 4729130 SRKASQTsVYLQEWD phosphorylation 23993095 1 0 0 induces phosphorylation of ERK +KAT8 MYST1 ACETYLTRANSFERASE; Acetyltransferase; EC 2.3.1.48 Q9H7Z6 84148 16p11.2 human K274-ac 479461 AKLFLDHkTLYFDVE MOZ_SAS protein stabilization; molecular association, regulation; acetylation; protein conformation; enzymatic activity, induced transcription, inhibited DNA(DISRUPTS) 21502975; 22020126; 27382063 4 1 9 inhibits H4 acetylation +RACGAP1 MgcRacGAP GAP; GAP, Rac/Rho Q9H0H5 29127 12q13.12 human S387-p 449096 ETGLYRIsGCDRTVK RhoGAP activity, induced cell cycle regulation; cell growth, altered 12689593; 19555392 2 0 0 regulates cytokinesis; overexpression of the S387D mutant enhances the colony-forming ability of the v-Src-transformed cells +GGA1 GGA1 Adaptor/scaffold; Vesicle Q9UJY5 26088 22q13.1 human T270-p 2907511 LFRLASDtEDNDEAL GAT intracellular localization 14690499 1 3 12 +SHCBP1 SHCBP1 Adaptor/scaffold Q8NEM2 79801 16q11.2 human S634-p 3206817 QIKKKRLsELGITQA molecular association, regulation; intracellular localization cell cycle regulation MgcRacGAP(DISRUPTS) 23704356 1 9 0 inactivation of Rac1 byMgcRacGap to induce cytokinetic furrow ingression +SLC12A2 NKCC1 Membrane protein, integral; Membrane protein, multi-pass; Transporter; Transporter, SLC family P55011 6558 5q23.3 human T207-p 467236 YYDTHTNtYYLRTFG AA_permease_N activity, induced; enzymatic activity, induced 16669787; 20442269; 22032326 12 1 0 +Jun Jun Oncoprotein; Transcription factor P05627 16476 4 C5|4 43.34 cM mouse S73-p 447943 VGLLKLAsPELERLI Jun activity, induced; sumoylation; molecular association, regulation; acetylation cell growth, induced; apoptosis, induced; cell motility, altered; transcription, induced; transcription, altered; cell growth, altered HDAC3(DISRUPTS); NFkB-p65(INDUCES) DNA(INDUCES) 10788439; 10851065; 12730213; 15122339; 16061693; 16964287; 18443042; 36070687 84 65 16 +FBXO25 FBXO25 UBIQUITIN LIGASE; Ubiquitin conjugating system; Ubiquitin ligase Q8TCJ0 26260 8p23.3 human S178-p 37043701 DLLQDLSsTLCILIR protein degradation; intracellular localization apoptosis, induced 25419709 1 0 0 protein degradation of HAX1 +FEN1 FEN1 DNA repair, damage; DNA-binding; Deoxyribonuclease; EC 3.1.-.-; Nuclear receptor co-regulator; Nucleolus; Ribonuclease P39748 2237 11q12.2 human K377-ac 458857 TGAAGKFkRGK____ molecular association, regulation; enzymatic activity, inhibited DNA(DISRUPTS) 11430825 1 1 0 +Atg5 ATG5 Apoptosis; Autophagy; Ubiquitin conjugating system Q99J83 11793 10 B2|10 23.24 cM mouse T75-p 27138202 IWFEYEGtPLKWHYP autophagy, inhibited 23059785 2 0 0 +TGFBR2 TGFBR2 EC 2.7.11.30; KINASE; Kinase, protein; Membrane protein, integral; Oncoprotein; Protein kinase, Ser/Thr (receptor); Protein kinase, TKL P37173 7048 3p24.1 human S31-gl 1873645300 IPPHVQKsVNNDMIV molecular association, regulation; protein conformation signaling pathway regulation TGFBR1(DISRUPTS) 33234595 1 1 0 downstream TGF-? signaling +Tbxa2r TXA2-R GPCR, family 1; Membrane protein, integral; Membrane protein, multi-pass; Receptor, GPCR P30987 21390 10 C1|10 39.72 cM mouse T230-p 3061800 VYHTREAtQRPRDCE 7tm_1 receptor desensitization, altered 12428680 1 0 0 GRK2 mediated but not PKC +SSTR2 SSTR2 GPCR, family 1; Membrane protein, integral; Membrane protein, multi-pass; Receptor, GPCR P30874 6752 17q25.1 human Y71-p 469597 VIYVILRyAKMKTIT 7tm_1 molecular association, regulation apoptosis, induced PIK3R1(INDUCES) 16917505 1 0 0 complex with PIK3R1 dissociates in the presence of somatostatin +Pten PTEN Carbohydrate Metabolism - inositol phosphate; EC 3.1.3.16; EC 3.1.3.48; EC 3.1.3.67; Motility/polarity/chemotaxis; Nuclear receptor co-regulator; PHOSPHATASE; Phosphatase, lipid; Tumor suppressor O08586 19211 19 C1|19 28.14 cM mouse T383-p 448315 HYRYSDTtDSDPENE enzymatic activity, inhibited 24367090 23 3 0 +FLI1 FLI1 DNA-binding; Oncoprotein; Transcription factor Q01543 2313 11q24.3 human K397-ac 28108003 SYHAHQQkVNFVPPH transcription, induced 22973553 1 0 0 +MAP4 MAP4 Cytoskeletal; Motility/polarity/chemotaxis P27816 4134 3p21.31 human K1060-ac 62495521 DVKIESQkLNFKEKA Tubulin-binding cytoskeletal reorganization 28002468 1 1 0 +GP1BA GPIbA Cell adhesion; Cell surface; Membrane protein, integral P07359 2811 17p13.2 human S651-p 450660 SIRYSGHsL______ molecular association, regulation 14-3-3 sigma(INDUCES); 14-3-3 zeta(INDUCES) 10559231; 18299448; 19874472 4 5 0 +Cd22 CD22 Cell surface; Membrane protein, integral P35329 12483 7 B1|7 19.26 cM mouse Y828-p 450943 QKRPMGDyENVNPSC molecular association, regulation; activity, inhibited GRB2(INDUCES); PMCA1(INDUCES) 11551923; 27276708 6 0 1 negatively regulate calcium signal +KIF11 KIF11 Microtubule-binding; Motor P52732 3832 10q23.33 human Y211-p 463258 VHNKDEVyQILEKGA Kinesin cytoskeletal reorganization 28646493 1 1 3 spindle morphology +Pou2af1 POU2AF1 Oncoprotein; Transcription, coactivator/corepressor Q64693 18985 9|9 A5.3 mouse Y245-p 29570702 EEEESNTyELNHTLS PD-C2-AF1 protein stabilization 24061476 1 0 0 +TP53 p53 Activator; DNA-binding; Motility/polarity/chemotaxis; Nuclear receptor co-regulator; Transcription factor; Tumor suppressor P04637 7157 17p13.1 human K164-ub 486296 VRAMAIYkQSQHMTE P53 protein degradation; molecular association, regulation; intracellular localization transcription, altered DNA(INDUCES) 17371868; 28362432 2 2 0 differential transcription-activation or inhibition at specific promoters +DISC1 DISC1 Cell development/differentiation; Motility/polarity/chemotaxis Q9NRI5 27185 1q42.2 human K643-sm 62504401 VKKLGSVkEDYNRLR intracellular localization cell growth, induced 27525255 1 0 0 +Cttn Cortactin Actin-binding; Cytoskeletal; Motility/polarity/chemotaxis Q60598 13043 7|7 F5 mouse S113-p 465664 SKLSKHCsQVDSVRG HS1_rep molecular association, regulation ACTA1(DISRUPTS) 16854367 3 16 17 co-sedimentation assays with f-actin +STAT1 STAT1 DNA-binding; Transcription factor P42224 6772 2q32.2 human S727-p 447753 TDNLLPMsPEEFDEV STAT1_TAZ2bind activity, induced; sumoylation; molecular association, regulation; intracellular localization cell cycle regulation; carcinogenesis, induced; cell growth, inhibited; cell motility, induced; apoptosis, induced; transcription, induced; signaling pathway regulation; transcription, altered; cell growth, induced; apoptosis, inhibited; cell growth, altered PIAS1(INDUCES); BRCA1(INDUCES) DNA(INDUCES) 10792030; 11438544; 11777927; 11884587; 12637327; 12807916; 14962955; 15051500; 15322115; 15994321; 16799645; 17897103; 21303487; 21398617; 21878628; 31988137; 33727660; 33747209; 34626802; 35196494; 36113429; 36154299; 36342456; 37272165; 7543024 118 32 90 +EPB41 EPB41 iso2 Cytoskeletal P11171-2 2035 1p35.3 human T60-p 467259 LKASNGDtPTHEDLT molecular association, regulation; intracellular localization cell cycle regulation NuMA-1(INDUCES); TUBA4A(INDUCES) 15525677 1 10 1 Also associates with tubulin and NuMA in vivo. Mutant EPB41 T60A-S679A abolishes localization to the mitotic spindle. +RPS3 RPS3 Apoptosis; EC 4.2.99.18; RNA-binding; Ribosomal; Translation P23396 6188 11q13.4 human K18-sm 25218902 FVADGIFkAELNEFL protein stabilization 21968017 1 2 0 +Ncl NCL DNA-binding; Helicase; Nuclear receptor co-regulator; Nucleolus; RNA-binding P09405 17975 1 C5|1 43.94 cM mouse S28-p 452262 PKEVEEDsEDEEMSE molecular association, regulation carcinogenesis, induced; cell growth, induced; transcription, induced RNA(INDUCES) 37039106 2 45 9 +GATA4 GATA4 Motility/polarity/chemotaxis; Transcription factor P43694 2626 8p23.1 human S262-p 450013 IKPQRRLsASRRVGL activity, induced; molecular association, regulation transcription, induced DNA(INDUCES) 16109788; 26946174 9 1 1 +PFKL PFKL Carbohydrate Metabolism - fructose and mannose; Carbohydrate Metabolism - galactose; Carbohydrate Metabolism - glycolysis and gluconeogenesis; Carbohydrate Metabolism - pentose phosphate pathway; EC 2.7.1.11; Kinase, other P17858 5211 21q22.3 human S775-p 468408 HVTRRTLsMDKGF__ enzymatic activity, induced 25131207 1 53 16 +TRPV6 TRPV6 Channel, calcium; Membrane protein, integral; Membrane protein, multi-pass Q9H1D0 55503 7q34 human S732-p 1868023605 SRSTSRSsANWERLR activity, induced carcinogenesis, induced 32186440 1 0 0 +CTTN Cortactin Actin-binding; Cytoskeletal; Motility/polarity/chemotaxis Q14247 2017 11q13.3 human K235-ac 461721 YVKGFGGkFGVQTDR HS1_rep molecular association, regulation; intracellular localization cell motility, inhibited ACTB(DISRUPTS) 17643370 2 4 21 Acetylation prevents localization to membrane ruf?es. +Rptor Raptor Adaptor/scaffold Q8K4Q0 74370 11|11 E2 mouse S722-p 2314601 PRLRSVSsYGNIRAV phosphorylation transcription, altered; signaling pathway regulation; translation, inhibited 32912901 9 52 7 inhibits S6 and ULK1 phosphorylation through inhibiting mTORC1 signaling +EIF5A2 EIF5A2 Q9GZV4 56648 3q26.2 human K47-ac 18546316 IVEMSTSkTGKHGHA intracellular localization 23132580 1 5 0 acetylated was localized to the nucleus while hypoacetylated was cytoplasmic +MYC Myc DNA-binding; Nucleolus; Oncoprotein; Transcription factor P01106 4609 8q24.21 human K338-ac 458888 RKDYPAAkRVKLDSV Myc_N protein degradation; acetylation; molecular association, regulation cell growth, inhibited; apoptosis, induced; transcription, induced ZBTB17(INDUCES) 16126174; 27358484; 30866966 7 4 5 induces CCA cell apoptosis by decreasing cMYC; induces association with ZBTB17 on specific target promoters; HDACi-mediated TRAIL induction +RBL2 Rb-like 2 Transcription, coactivator/corepressor; Tumor suppressor Q08999 5934 16q12.2 human T401-p 449723 SKALRIStPLTGVRY molecular association, regulation cell cycle regulation; transcription, induced E2F4(DISRUPTS) 11157749; 12006580; 28289097 3 12 32 +GATA1 GATA1 DNA-binding; Transcription factor P15976 2623 Xp11.23 human K137-sm 3819000 TSFLETLkTERLSPD molecular association, regulation; intracellular localization cell growth, inhibited; transcription, inhibited; transcription, altered DNA(INDUCES) 20064464; 27821551; 35342335 4 0 0 decreased expression of CSN5 and ZEB1 +Otud5 OTUD5 DEUBIQUITINASE; EC 3.4.19.12; Protease; Ubiquitin-specific protease Q3U2S4 54644 X A1.1|X 3.54 cM mouse S323-p 1870773108 EDEPIRVsYHRNIHY OTU protein degradation; protein stabilization; molecular association, regulation; ubiquitination; phosphorylation; enzymatic activity, induced cell cycle regulation; cell growth, induced; autophagy, inhibited; transcription, altered; signaling pathway regulation BTRC(DISRUPTS) 33110214 1 1 0 inhibits ubiquitination and induces stabilization of OTUD5 and BTRCP1 further causing DEPTOR degradation, regulates phosphorylation of mTOR targets, promotes OTUD5-?TrCP1-DEPTOR pathway +BLVRA BVR Cofactor and Vitamin Metabolism - porphyrin and chlorophyll; EC 1.3.1.24; KINASE; Kinase, protein; Oxidoreductase; Protein kinase, Ser/Thr (non-receptor) P53004 644 7p13 human S230-p 478716 LKRNRYLsFHFKSGS Biliv-reduc_cat intracellular localization; enzymatic activity, induced; phosphorylation transcription, induced 17639074; 22584576 3 26 66 induces autophosphorylation of the protein and phosphorylation of PKCZ +Pdc phosducin G protein regulator, misc. P20942 25343 13q21 rat S36-p 10431702 WRKFKLEsEDGDSIP Phosducin molecular association, regulation G-gamma 2(DISRUPTS); G-beta 1(DISRUPTS) 11331285 1 0 1 +Pdgfrb PDGFRB EC 2.7.10.1; KINASE; Kinase, protein; Membrane protein, integral; Oncoprotein; Protein kinase, TK; Protein kinase, tyrosine (receptor) Q05030 rat Y856-p 447509 DIMRDSNyISKGSTF PK_Tyr_Ser-Thr cell motility, induced; cell growth, induced 34858182 17 2 3 +KEAP1 KEAP1 Endoplasmic reticulum; Motility/polarity/chemotaxis; Transcription regulation; UBIQUITIN LIGASE; Ubiquitin conjugating system Q14145 9817 19p13.2 human S602-p 29606703 TRMTSGRsGVGVAVT protein stabilization; molecular association, regulation carcinogenesis, inhibited; apoptosis, inhibited NRF2(INDUCES) 24127568 1 1 0 +CALR Calreticulin ACETYLTRANSFERASE; Acetyltransferase; Calcium-binding; Motility/polarity/chemotaxis; Nuclear receptor co-regulator; Secreted; Secreted, signal peptide P27797 811 19p13.13 human K209-ac 4219811 FLPPKKIkDPDASKP Calreticulin protein conformation 18795239 1 6 0 +SIAH2 SIAH2 EC 6.3.2.-; EC 6.3.2.19; Ligase; Transcription, coactivator/corepressor; UBIQUITIN LIGASE; Ubiquitin conjugating system; Ubiquitin ligase O43255 6478 3q25.1 human S68-p 5393502 GGGAGPVsPQHHELT protein degradation; molecular association, regulation; intracellular localization; enzymatic activity, induced cytoskeletal reorganization HIPK2(DISRUPTS) 19043406; 22878263; 23044042; 26751770 5 2 0 +FGFR2 FGFR2 EC 2.7.10.1; KINASE; Kinase, protein; Membrane protein, integral; Oncoprotein; Protein kinase, TK; Protein kinase, tyrosine (receptor) P21802 2263 10q26.13 human Y769-p 448113 TLTTNEEyLDLSQPL molecular association, regulation; enzymatic activity, induced cell growth, altered FRS2(INDUCES); PLCG1(INDUCES) 15629145 5 1 0 +GTF2I GTF2I DNA-binding; Transcription, coactivator/corepressor P78347 2969 7q11.23 human Y248-p 448250 EESEDPDyYQYNIQA activity, induced; intracellular localization transcription, induced; transcription, altered 15664986; 16738337; 20568114; 9837922 8 2 9 +HMGA1 HMGA1 DNA-binding P17096 3159 6p21.31 human T78-p 451516 KTRKTTTtPGRKPRG molecular association, regulation DNA(INDUCES) 17960875 3 7 2 Cdc2 phosphorylated HMGA1 has lower binding affinity than HIPK2 phosphorylated HMGA1. +TBL1XR1 TBL1XR1 Nuclear receptor co-regulator; Transcription, coactivator/corepressor Q9BZK7 79718 3q26.32 human K497-sm 20745209 CWNAAGDkVGASASD acetylation; molecular association, regulation carcinogenesis, induced; cell growth, induced; transcription, induced; signaling pathway regulation TCF4(INDUCES); SMRT(DISRUPTS); N-CoR1(DISRUPTS); HDAC3(DISRUPTS); CTNNB1(INDUCES) DNA(INDUCES) 21777810; 27129164 2 0 0 TCF4 was bound to TBL1X but not TBL1XR1, sumoylation enhances the recruitment to Wnt target gene promoters, activates Wnt signaling pathway ; induces histone acetylation +Prkcd PKCD EC 2.7.11.13; KINASE; Kinase, protein; Nuclear receptor co-regulator; Protein kinase, AGC; Protein kinase, Ser/Thr (non-receptor); Protein kinase, tyrosine (non-receptor); Tumor suppressor P09215 170538 16p16 rat Y311-p 447573 TPETVGIyQGFEKKT protein degradation; enzymatic activity, induced apoptosis, induced 10319993; 11381116; 14715667; 15961393; 18550549; 19161989 44 60 1707 +TRAIP TRAIP EC 6.3.2.-; Ligase; Nucleolus; UBIQUITIN LIGASE; Ubiquitin conjugating system; Ubiquitin ligase Q9BWF2 10293 3p21.31 human K247-sm 53529100 YSELDQAkLELKSAQ protein stabilization; ubiquitination; intracellular localization 26820530 2 0 0 inhibits ubiquitination +FANCI FANCI Cell cycle regulation; DNA repair, damage Q9NVI1 55215 15q26.1 human K523-ub 486579 CLILVLRkAMFANQL FANCI_S2 intracellular localization DNA repair, induced; DNA repair, inhibited 17460694; 20971953; 21896657; 22855611 8 10 93 +KPNA2 KPNA2 Karyopherin; Nuclear import; Nucleoporin P52292 3838 17q24.2 human K22-ac 458963 HRFKNKGkDSTEMRR IBB activity, induced; molecular association, regulation; intracellular localization HuR(INDUCES) 10801418; 15342649; 17919121 4 0 0 regulates HuR nuclear import through S105 phosphorylation and K22 acetylation ; promotes the nuclear localization of HuR; increases interaction with importin-beta in vitro +CERS4 LASS4 DNA-binding; Membrane protein, integral; Membrane protein, multi-pass Q9HA82 79603 19p13.2 human S342-p 7102766 QMEKDIRsDVEESDS enzymatic activity, induced 26887952 1 9 0 +POLI POLI DNA repair, damage; EC 2.7.7.7; Transferase Q9UNA4 11201 18q21.2 human K112-ub 50771303 NVRDAKEkCPQLVLV IMS protein degradation 26370087 1 3 0 +HIPK2 HIPK2 EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, CMGC; Protein kinase, Ser/Thr (non-receptor) Q9H2X6 28996 7q34 human S121-p 28847902 LMRRSTVsLLDTYQK protein stabilization; molecular association, regulation; phosphorylation; enzymatic activity, induced PPM1D(DISRUPTS) 23871434 1 0 0 increase protein stabilization and reduce phosphorylation of WIP1 +GAPDH GAPDH Carbohydrate Metabolism - glycolysis and gluconeogenesis; EC 1.2.1.12; Oxidoreductase P04406 2597 12p13.31 human T99-p 23109029 AEYVVEStGVFTTME Gp_dh_N enzymatic activity, induced 26629320 1 2 1 +Slc1a2 GLT1 Membrane protein, integral; Membrane protein, multi-pass; Transporter; Transporter, SLC family P31596 29482 3q32 rat S113-p 450073 SGLDAKAsGRLGTRA SDF activity, induced 7903307 1 0 0 +PLN PLB Inhibitor; Membrane protein, integral P26678 5350 6q22.31 human S16-p 448114 RSAIRRAsTIEMPQQ Phospholamban activity, induced; molecular association, regulation; activity, inhibited; protein conformation; enzymatic activity, induced SERCA2(DISRUPTS); ATP2A1(DISRUPTS) 11854448; 12134142; 18708665; 33897445; 35605666; 35805951 78 15 66 +FOXO1 FOXO1A DNA-binding; Nuclear receptor co-regulator; Oncoprotein; Transcription factor Q12778 2308 13q14.11 human K245-ac 459030 MLNPEGGkSGKSPRR Forkhead molecular association, regulation; intracellular localization; activity, inhibited; phosphorylation carcinogenesis, inhibited; apoptosis, induced; transcription, inhibited DNA(DISRUPTS) 15220471; 16076959; 18786403; 20519497; 27132507 9 1 0 +Mpl MPL Membrane protein, integral; Receptor, cytokine Q08351 17480 4 D2.1|4 54.61 cM mouse S522-p 3091402 LRHALWPsLPDLHRV activity, induced; phosphorylation cell growth, altered 10918061 1 0 0 tyrosine phosphorylation of JAK2 +CENPQ CENPQ Q7L2Z9 55166 6p12.3 human T123-p 40245503 RLLQQCEtLKVPPKK CENP-Q molecular association, regulation; intracellular localization DNA(DISRUPTS) 25670858 1 1 0 CENPQ phosphorylation promotes the delocalization of the PBIP1-CENPQ complex from kinetochores +Mob1b MOB1B Activator; Protein kinase, regulatory subunit Q8BPB0 68473 5|5 E1 mouse T12-p 3545000 FGSRSSKtFKPKKNI activity, induced; molecular association, regulation; protein conformation LATS1(INDUCES) 27335147 3 1 3 +FAAP20 FAAP20 iso2 Q6NZ36 199990 1p36.33 human S113-p 27445146 GAGGHLEsPARSLPQ FANCA_interact protein degradation; ubiquitination FBXW7(INDUCES) 27232758 2 10 0 +PPP1R13L PPP1R13L Apoptosis; Phosphatase, regulatory subunit; Transcription, coactivator/corepressor Q8WUF5 10848 19q13.32 human S113-p 465657 LHPYSPLsPKGRPSS molecular association, regulation; intracellular localization; protein conformation cell growth, inhibited p53(INDUCES); PPP1R13L(DISRUPTS) 23623661; 30105797 2 29 9 miR-129 inhibits phosphorylation, blocks nuclear localization and inhibits cell proliferation, p53 and TAp63 levels increased, inhibiting proliferation of Burkitt lymphoma cells; prevents N- and C-terminal self interaction, enhances binding to p53 +Ezh2 EZH2 EC 2.1.1.43; METHYLTRANSFERASE; Methyltransferase; Methyltransferase, protein lysine Q61188 14056 6 B2.3|6 22.92 cM mouse T345-p 4957354 LTAERIKtPPKRPGG protein degradation; molecular association, regulation RNA(INDUCES) 21123648; 30305391 11 12 2 +DEPTOR DEPTOR Apoptosis Q8TB45 64798 8q24.12 human S297-p 4723868 FSSSPTLsSSPPVLC protein degradation; molecular association, regulation carcinogenesis, induced; apoptosis, inhibited; signaling pathway regulation mTOR(DISRUPTS) 19446321 3 3 0 PI3K-Akt signaling +TAGAP TAGAP GAP; GAP, Rac/Rho Q8N103 117289 6q25.3 human Y310-p 6154570 TLQNDSAyDSNDPDV molecular association, regulation; intracellular localization; phosphorylation signaling pathway regulation CARD9(INDUCES) 32312989 1 1 1 induces phosphorylation of ERK and p38, regulates anti-fungal signaling pathway +EGFR EGFR EC 2.7.10.1; KINASE; Kinase, protein; Membrane protein, integral; Oncoprotein; Protein kinase, TK; Protein kinase, tyrosine (receptor) P00533 1956 7p11.2 human K1061-ac 49182100 GLQSCPIkEDSFLQR carcinogenesis, inhibited; cell motility, inhibited; signaling pathway regulation 26290602 1 1 0 inhibits EGFR-MAPK signaling +H3C1 H3 DNA-binding P68431 8350 6p22.2 human R17-m2 1968602 STGGKAPrKQLATKA Histone cell differentiation, inhibited; autophagy, induced; transcription, induced 15471871; 20022955; 23301034; 27309807 9 0 0 +STK38 NDR1 EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, AGC; Protein kinase, Ser/Thr (non-receptor) Q15208 11329 6p21.31 human T7-p 22553317 _MAMTGStPCSSMSN molecular association, regulation; intracellular localization; enzymatic activity, inhibited; protein conformation; phosphorylation cell cycle regulation; cytoskeletal reorganization; signaling pathway regulation MOB1A(DISRUPTS); HCCA2(INDUCES) 22142472; 26057687 2 1 0 induces JNK phosphorylation, regulates cell death through JNK signaling; regulation of spindle orientation, cortical localization of LGN-NuMA +TP53 p53 Activator; DNA-binding; Motility/polarity/chemotaxis; Nuclear receptor co-regulator; Transcription factor; Tumor suppressor P04637 7157 17p13.1 human K370-ne 12067102 RAHSSHLkSKKGQST transcription, inhibited 15242646 1 0 0 +Elk1 ELK1 DNA-binding; Transcription factor P41969 13712 X A1.3|X 16.45 cM mouse T354-p 22725900 QAPGPALtPSLLPTH molecular association, regulation transcription, induced MED16(INDUCES); MED23(INDUCES); Trap100(INDUCES) 27738173 2 0 0 +ADRB2 ADRB2 GPCR, family 1; Membrane protein, integral; Membrane protein, multi-pass; Receptor, GPCR P07550 154 5q32 human S396-p 457440 GHQGTVPsDNIDSQG protein conformation 21868357 4 1 0 +RELA NFkB-p65 DNA-binding; Nuclear receptor co-regulator; Transcription factor Q04206 5970 11q13.1 human K310-ub 25087015 KRTYETFkSIMKKSP transcription, inhibited 21706061 1 2 0 inhibits acetylation +SNIP1 SNIP1 Inhibitor Q8TAD8 79753 1p34.3 human S35-p 470652 VVKQERLsPEVAPPA sumoylation 27703003 1 66 5 S35 phosphorylation induces SNIP1 SUMOylation +FLNA FLNA Actin-binding; Motility/polarity/chemotaxis; Nuclear receptor co-regulator P21333 2316 Xq28 human S2523-p 448843 VTGPRLVsNHSLHET intracellular localization cytoskeletal reorganization 11290523 2 4 0 +ALDOA ALDOA Carbohydrate Metabolism - fructose and mannose; Carbohydrate Metabolism - glycolysis and gluconeogenesis; Carbohydrate Metabolism - pentose phosphate pathway; EC 4.1.2.13; KINASE; Lyase; Mitochondrial P04075 226 16p11.2 human S36-p 455261 GILAADEsTGSIAKR Glycolytic carcinogenesis, induced; cell growth, induced 31585088 1 43 2 +PARP3 PARP3 DNA repair, damage; EC 2.4.2.30; Transferase Q9Y6F1 10039 3p21.2 human S461-p 40682500 TDNPSLKsPPPGFDS PARP DNA repair, induced 25886813 1 1 0 +SSRP1 SSRP1 Nucleolus; RNA-binding; Transcription initiation complex; Transcription, coactivator/corepressor Q08945 6749 11q12.1 human S688-p 456296 KRRRSEDsEEEELAS activity, inhibited transcription, altered 15659405 1 0 0 +PARP1 PARP1 DNA repair, damage; EC 2.4.2.30; Nuclear envelope; Nuclear receptor co-regulator; Nucleolus; Transferase P09874 142 1q42.12 human S372-p 463804 VAATPPPsTASAPAA enzymatic activity, induced transcription, induced 16627622; 23597856 2 2 1 +Pias2 PIAS2 EC 6.3.2.-; Nuclear receptor co-regulator; SUMO LIGASE; SUMO conjugating system; SUMO ligase; Transcription, coactivator/corepressor Q6AZ28 83422 18q12.3 rat S116-p 464654 IAPHSPSsPVASVLL transcription, altered 16713578 1 0 0 important for Elk1-mediated transcriptional activation +Nr4a1 Nur77 Apoptosis; DNA-binding; Nuclear receptor P12813 15370 15|15 F1 mouse S142-p 2591500 GSPCSAPsPSTPNFQ intracellular localization transcription, altered 10878809 3 0 0 +EP300 p300 ACETYLTRANSFERASE; Acetyltransferase; EC 2.3.1.48; Motility/polarity/chemotaxis; Nuclear receptor co-regulator; Transcription, coactivator/corepressor Q09472 2033 22q13.2 human K1020-ac 458944 EERSTELkTEIKEEE activity, inhibited transcription, inhibited 15632193 2 1 0 +NFE2L2 NRF2 DNA-binding; Transcription factor Q16236 4780 2q31.2 human K472-ac 7106321 HIPFPVEkIINLPVV bZIP_Maf molecular association, regulation transcription, induced DNA(INDUCES) 19273602 1 1 0 +DHCR24 Diminuto EC 1.3.1.72; Lipid Metabolism - steroid biosynthesis; Membrane protein, integral; Oxidoreductase Q15392 1718 1p32.3 human Y507-p 449497 QDAFPEVyDKICKAA enzymatic activity, induced 24363437 1 1 14 +OPRK1 KOR-1 GPCR, family 1; Membrane protein, integral; Membrane protein, multi-pass; Receptor, GPCR P41145 4986 8q11.23 human K349-ub 1975301 RDFCFPLkMRMERQS receptor internalization, induced; protein degradation 18212250 1 0 0 ubiquitination regulates but is not required for receptor downregulation +Chrna7 nAChRA7 Channel, cation; Channel, ligand-gated; Membrane protein, integral; Membrane protein, multi-pass P49582 11441 7 C|7 34.47 cM mouse S365-p 451182 QHKPRRCsLASVELS Neur_chan_memb intracellular localization; activity, inhibited 25990637 2 0 0 +Dusp8 DUSP8 EC 3.1.3.16; EC 3.1.3.48; Motility/polarity/chemotaxis; PHOSPHATASE; Protein phosphatase, dual-specificity O09112 18218 7 F5|7 87.59 cM mouse S520-p 22598804 LDSPGTPsPDGPWCF enzymatic activity, inhibited signaling pathway regulation 22100391 1 1 0 activates JNK pathway +Stk39 STLK3 EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, STE; Protein kinase, Ser/Thr (non-receptor) Q9Z1W9 53416 2|2 C1.3 mouse T247-p 458885 VRKTFVGtPCWMAPE Pkinase enzymatic activity, induced 16382158 1 1 25 +TRIM25 TRIM25 EC 6.3.2.19; EC 6.3.2.n3; Ligase; Nuclear receptor co-regulator; Transcription factor; UBIQUITIN LIGASE; Ubiquitin conjugating system; Ubiquitin ligase Q14258 7706 17q22 human K439-ub 12332222 NSTSLKAkVLETFLA protein degradation; protein stabilization; intracellular localization 35079021 1 8 18 USP44 recruits and stabilizes TRIM25 and inhibits its ubiquitylation and promotes the ubiquitiylation and degradation of Ku80. USP44 increases the radiosensitivity of NPC nasopharyngeal carcinoma cells (NPC) in vivo. +MAP3K7 TAK1 EC 2.7.11.25; KINASE; Kinase, protein; Protein kinase, Ser/Thr (non-receptor); Protein kinase, TKL O43318 6885 6q15 human T538-p 971232900 QEYMKVQtEIALLLQ molecular association, regulation IKKG(INDUCES) 29511289 1 1 0 +Trpm7 ChaK1 Channel, cation; EC 2.7.11.1; KINASE; Kinase, protein; Membrane protein, integral; Membrane protein, multi-pass; Protein kinase, Ser/Thr (non-receptor); Protein kinase, atypical Q923J1 58800 2|2 F1 mouse S1567-p 455464 NLMRLSQsIPFVPVP molecular association, regulation; intracellular localization 14-3-3 theta(INDUCES) 29866880 3 9 0 S1403 is a stronger interaction site +Dnm1l DRP1 Apoptosis; EC 3.6.5.5; Endoplasmic reticulum; Hydrolase; Microtubule-binding; Mitochondrial; Motor Q8K1M6 74006 16|16 A2 mouse S622-p 454690 PIPIMPAsPQKGHAV activity, induced; intracellular localization carcinogenesis, induced; apoptosis, altered; carcinogenesis, inhibited; cell growth, inhibited; apoptosis, induced; cell motility, inhibited; transcription, altered; signaling pathway regulation; autophagy, induced; cell growth, induced; cytoskeletal reorganization; transcription, inhibited 25658204; 27739424; 30511961; 33485986; 33516941; 33539906; 33913175; 34535949; 34562609; 34631868; 34940790; 35165418; 35412849; 35791786; 35860026; 35865967; 36078152; 36327794; 36813093; 37232152 132 78 114 induces mitophagy; inhibits the cGMP-AMP synthase (cGAS) pathway +Cat Catalase Amino Acid Metabolism - tryptophan; Apoptosis; EC 1.11.1.6; Endoplasmic reticulum; Energy Metabolism - methane; Hydrolase; Mitochondrial; Oxidoreductase P24270 12359 2 E2|2 54.43 cM mouse Y386-p 450445 YRARVANyQRDGPMC Catalase protein degradation; enzymatic activity, induced 12950161 2 0 0 +JAK1 JAK1 EC 2.7.10.2; KINASE; Kinase, protein; Protein kinase, TK; Protein kinase, tyrosine (non-receptor) P23458 3716 1p31.3 human S518-p 62372201 GSDRSFPsLGDLMSH molecular association, regulation 27919027 1 0 0 +Lrp1 LRP1 Cell surface; Membrane protein, integral; Motility/polarity/chemotaxis; Receptor, misc. G3V928 299858 7q22 rat Y4474-p 473712 VEIGNPTyKMYEGGE molecular association, regulation GRB2(INDUCES); CSK(INDUCES); PLCB1(INDUCES); SNX17(DISRUPTS); PIK3R1(INDUCES) 19771558 4 3 2 +PHLPP1 PHLPP EC 3.1.3.16; PHOSPHATASE; Protein phosphatase, Ser/Thr (non-receptor); Tumor suppressor O60346 23239 18q21.33 human S411-p 1871700802 LPLPQTAsSPQPQQK cell cycle regulation 33397691 1 1 0 +Ikbkb IKKB EC 2.7.11.10; KINASE; Kinase, protein; Protein kinase, Other; Protein kinase, Ser/Thr (non-receptor) O88351 16150 8|8 A2 mouse S701-p 17934904 ACDSLPEsDKKSEEL molecular association, regulation; phosphorylation PPP2R3C(INDUCES) 20925653 1 0 0 interaction with PPP2R3C (aka G4-1) downregulates IKK-beta activity; S181 phosphorylation increased in S679/682/689/692/697/701/705A mutant +SPP1 osteopontin Secreted; Secreted, signal peptide P10451 6696 4q22.1 human S126-p 455739 QSDESHHsDESDELV Osteopontin molecular association, regulation; activity, inhibited Other(INDUCES) 19775205 1 5 0 peptide with phosphorylated S117, S120, S123, S126 and S129 has increased binding to hydroxyapatite, and inhibits bone mineralization in vivo and in vitro +EIF2AK2 PKR EC 2.7.10.2; EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, Other; Protein kinase, Ser/Thr (non-receptor); Protein kinase, tyrosine (non-receptor); Translation P19525 5610 2p22.2 human S242-p 448085 NQRKAKRsLAPRFDL enzymatic activity, induced 11152499 2 2 0 +BCL2 Bcl-2 Apoptosis; Autophagy; Membrane protein, integral; Oncoprotein P10415 596 18q21.33 human K22-ub 52477000 VMKYIHYkLSQRGYE BH4 protein degradation apoptosis, induced 26556865 1 1 0 increased cancer cell chemotherapy sensitivity +TOP2A TOP2A EC 5.99.1.3; Isomerase P11388 7153 17q21.2 human S1525-p 448764 PIKYLEEsDEDDLF_ molecular association, regulation; intracellular localization; enzymatic activity, induced cell cycle regulation; chromatin organization, altered; apoptosis, induced MDC1(INDUCES) 18171681; 19098900; 27407105 5 38 9 required for the decatenation checkpoint; required for normal sister chromatid segregationi late mitosis +SMAD7 SMAD7 DNA-binding; Transcription factor O15105 4092 18q21.1 human T96-p 15613800 EADLKALtHSVLKKL MH1 molecular association, regulation signaling pathway regulation TGFBR1(DISRUPTS) 20659902 2 0 0 regulates TGFB1 signaling +DDR1 DDR1 EC 2.7.10.1; KINASE; Kinase, protein; Membrane protein, integral; Protein kinase, TK; Protein kinase, tyrosine (receptor) Q08345 780 6p21.33 human Y484-p 1016886 GPREPPPyQEPRPRG activity, induced 24509848 0 5 46 phosphorylated in the N211QDDR1 mutant +USP1 USP1 DEUBIQUITINASE; EC 3.4.19.12; Protease; Ubiquitin conjugating system; Ubiquitin-specific protease O94782 7398 1p31.3 human S313-p 3177796 ATSDTLEsPPKIIPK UCH enzymatic activity, induced WDR48(INDUCES) 23116119 1 16 6 +FOXO1 FOXO1A DNA-binding; Nuclear receptor co-regulator; Oncoprotein; Transcription factor Q12778 2308 13q14.11 human T402-p 12607400 PGTMMQQtPCYSFAP intracellular localization transcription, altered 20061393 1 0 0 multiple site mutant (8A) +Tbc1d1 TBC1D1 DEUBIQUITINASE; GAP; GAP, Rab; Ubiquitin-specific protease Q60949 57915 5 C3.1|5 32.8 cM mouse S231-p 2103609 RPMRKSFsQPGLRSL transcription, inhibited 35061665 10 43 97 destabilizes PPARG +Crtc2 TORC2 Transcription, coactivator/corepressor Q3U182 74343 3|3 F1 mouse K628-ub 487505 DSSPGFSkEIAAALA TORC_C protein degradation 17805301 1 0 0 +FOS Fos DNA-binding; Motility/polarity/chemotaxis; Oncoprotein; Transcription factor P01100 2353 14q24.3 human S308-p 7388000 ADWEPLHsGSLGMGP protein stabilization 19285436 1 0 0 +Ywhab 14-3-3 beta Adaptor/scaffold P35213 56011 3q42 rat S65-p 467269 RSSWRVIsSIEQKTE 14-3-3 intracellular localization transcription, altered 12619878 1 2 0 Double mutant inhibited a MEF2 reporter and promotes nuclear localization of HDAC4/GFP. +GSK3A GSK3A EC 2.7.11.1; EC 2.7.11.26; KINASE; Kinase, protein; Protein kinase, CMGC; Protein kinase, Ser/Thr (non-receptor) P49840 2931 19q13.2 human Y279-p 447723 RGEPNVSyICSRYYR Pkinase enzymatic activity, induced apoptosis, altered 18701488 17 126 4206 +PRKCZ PKCZ EC 2.7.11.13; KINASE; Kinase, protein; Protein kinase, AGC; Protein kinase, Ser/Thr (non-receptor) Q05513 5590 1p36.33 human T410-p 447510 GPGDTTStFCGTPNY Pkinase molecular association, regulation; protein conformation; enzymatic activity, induced cytoskeletal reorganization TNNI1(INDUCES); desmin(INDUCES); TPM1(INDUCES); MYO1C(INDUCES); TNNT1(INDUCES) 10075713; 12887331; 12970779; 15314172; 16129678; 17335005; 17724026; 18258854; 20407013; 21281788 45 3 10 +SSB SSB Transcription initiation complex P05455 6741 2q31.1 human S366-p 449301 GKKTKFAsDDEHDEH activity, induced; activity, inhibited transcription, induced; transcription, inhibited 10983981; 18257391; 23231081; 9054510 10 68 130 inhibits recycling of RNA pol III complexes; S366A mutant had reduced viral gene expression. +Irs2 IRS2 Adaptor/scaffold; Motility/polarity/chemotaxis P81122 384783 8 A1.1|8 5.35 cM mouse S573-p 483923 GLRKRTYsLTTPARQ molecular association, regulation 14-3-3 beta(INDUCES) 22912850 2 40 11 +SMARCA4 SMARCA4 Cell cycle regulation; EC 3.6.1.-; EC 3.6.4.-; Helicase; Nuclear receptor co-regulator; Transcription, coactivator/corepressor; Tumor suppressor P51532 6597 19p13.2 human S35-p 1261736701 LGPSPGPsPGSAHSM protein degradation; molecular association, regulation; ubiquitination FBXW7(INDUCES) 30177679 1 0 0 +ALDOA ALDOA Carbohydrate Metabolism - fructose and mannose; Carbohydrate Metabolism - glycolysis and gluconeogenesis; Carbohydrate Metabolism - pentose phosphate pathway; EC 4.1.2.13; KINASE; Lyase; Mitochondrial P04075 226 16p11.2 human K13-ac 466408 PALTPEQkKELSDIA intracellular localization; enzymatic activity, induced carcinogenesis, induced; cell growth, induced 36209516 1 3 113 increased glycolysis which leading to tumor development and metastasis +FKBP1A FKBP12 EC 5.2.1.8; Isomerase P62942 2280 20p13 human K48-ub 22244556 RDRNKPFkFMLGKQE FKBP_C protein conformation 31375563 1 6 0 Partially unfolded but not aggregated drives FKBP12 ubiquitylation at the proteasome +Hnf4a HNF4 alpha DNA-binding; Nuclear receptor; Transcription factor P49698 15378 2 H3|2 84.32 cM mouse S303-p 20510205 DPDAKGLsDPGKIKR Hormone_recep molecular association, regulation SSU72(INDUCES) 34616001 2 1 0 +NR3C2 MCR DNA-binding; Nuclear receptor P08235 4306 4q31.23 human S459-p 386186600 FMDGSYFsFMDDKDY molecular association, regulation transcription, induced DNA(INDUCES) 29127314 1 0 0 ELISA-based transcription factor DNA binding assay (Tf-ELISA) +XRCC1 XRCC1 DNA repair, damage P18887 7515 19q13.31 human S408-p 3181459 YLMAGPGsSSEEDEA molecular association, regulation PARP1(DISRUPTS) 25477519 2 5 0 +HIF1A HIF1A Autophagy; DNA-binding; Transcription factor Q16665 3091 14q23.2 human K32-me 1883300100 AARSRRSkESEVFYE intracellular localization transcription, inhibited 35859119 1 1 0 Set7 upregulates HIF-1a target protein expression +HSPA1A HSP70 Chaperone; Heat shock protein; Motility/polarity/chemotaxis P0DMV8 3303 6p21.33 human S633-p 18010650 GPKGGSGsGPTIEEV intracellular localization apoptosis, induced 24623308 1 12 0 spindle elongation +Pax8 PAX8 Transcription factor Q00288 18510 2 A3|2 16.43 cM mouse K309-sm 5009200 PHSPFAIkQETPELS protein stabilization 18974227 1 0 0 +Esr2 ER-beta DNA-binding; Nuclear receptor O08537 13983 12 C3|12 33.52 cM mouse S236-p 473056 VRRQRSAsEQVHCLN protein degradation; molecular association, regulation; intracellular localization MDM2(INDUCES) 17166829; 22349818 2 0 0 +PLCG1 PLCG1 Carbohydrate Metabolism - inositol phosphate; EC 3.1.4.11; Motility/polarity/chemotaxis; Phospholipase P08487 281987 cow Y775-p 448907 EPDYGALyEGRNPGF enzymatic activity, induced transcription, altered 15879121 2 17 368 Mutation of Y775 or Y783 reduced PLCG1-mediated calcium mobilization and transcriptional activation +Clk2 CLK2 EC 2.7.12.1; KINASE; Kinase, protein; Protein kinase, CMGC; Protein kinase, dual-specificity (non-receptor) O35491 12748 3|3 F1 mouse T343-p 26375903 HHSTIVStRHYRAPE Pkinase enzymatic activity, induced 20074525 1 0 0 +AQP2 AQP2 Channel, misc.; Membrane protein, integral; Membrane protein, multi-pass; Transporter; Transporter, aquaporin family P41181 359 12q13.12 human T269-p 3339002 PQSLPRGtKA_____ molecular association, regulation; intracellular localization endocytosis, inhibited VTA1(DISRUPTS) 22778181; 28710278; 32486031; 32529500 37 5 0 +LBR LBR DNA-binding; Membrane protein, integral; Membrane protein, multi-pass G1N806 turkey S84-p 14575424 RSRSRSRsPGRPAKG molecular association, regulation; protein conformation H3(INDUCES) 22056509 2 5 0 +MCPH1 MCPH1 Cell cycle regulation Q8NEM0 79648 8p23.1 human S322-p 36125335 QKQAAGMsQETFEEK Microcephalin molecular association, regulation; phosphorylation signaling pathway regulation TOPBP1(INDUCES) 25301947 1 1 0 induces phosphrylation of RFA2, induce ATR signaling +TRIM28 TIF1B EC 6.3.2.-; KINASE; Kinase, protein; Ligase; Nuclear receptor co-regulator; Protein kinase, atypical; SUMO LIGASE; SUMO ligase; Transcription, coactivator/corepressor; UBIQUITIN LIGASE; Ubiquitin conjugating system; Ubiquitin ligase Q13263 10155 19q13.43 human K676-sm 3142607 CHVLPDLkEEDGSLS transcription, inhibited 31391303 2 2 0 loss of TF1B sumoylation induces dsRNA-activated IFN-mediated defenses that rely on RIG-I, MAVS, TBK1, and JAK1 transcription, SUMOylated TIF1B Is required to support efficient virus replication +Rb1 Rb Nuclear receptor co-regulator; Oncoprotein; Transcription, coactivator/corepressor; Tumor suppressor P13405 19645 14 38.73 cM|14 D3 mouse S781-p 450022 PIPHIPRsPYKFSSS Rb_C molecular association, regulation cell cycle regulation; transcription, inhibited E2F1(DISRUPTS) 10207050; 9671466 12 20 79 transcriptional downregulation of the E2F-1, E2F-2, dihydrofolate reductase, thymidine kinase, c-myc, proliferating-cell nuclear antigen, p107, and p21/Cip1 genes +PTTG1 Securin Cell cycle regulation; Oncoprotein O95997 9232 5q33.3 human S184-p 20764100 NLLQSPSsILSTLDV Securin protein degradation cell cycle regulation 21757741 2 0 0 +TAF1C TAF1C Transcription initiation complex Q15572 9013 16q24.1 human T852-p 31864668 ATRSQQHtPVLSSSQ cell cycle regulation; transcription, inhibited 26023773 1 3 0 +ARHGAP25 ARHGAP25 GAP; GAP, Rac/Rho P42331 9938 2p13.3 human S379-p 14822408 KAPVARSsVGWDATE endocytosis, induced; cytoskeletal reorganization 36190314 1 5 2 +ACADVL ACADVL EC 1.3.8.9; Lipid Metabolism - fatty acid; Mitochondrial; Oxidoreductase P49748 37 17p13.1 human K507-sc 40477504 LLLGEAGkQLRRRAG molecular association, regulation CRLS1(INDUCES) 25811481 1 0 0 both SIRT3 and SIRT5 KO show reduced afinity for CRLS1 +NEUROG3 neurogenin 3 Cell development/differentiation; DNA-binding; Transcription factor Q9Y4Z2 50674 10q22.1 human S183-p 35527103 VSQAGSLsPAASLEE transcription, inhibited 28441528 2 0 0 +CTCF CTCF C2H2-type zinc finger protein; Transcription factor; Tumor suppressor P49711 10664 16q22.1 human K689-sm 6124704 ENIIVEVkKEPDAEP transcription, induced 22354964 2 3 0 +CDKN1C p57Kip2 Cell cycle regulation; Inhibitor; Nuclear receptor co-regulator; Tumor suppressor P49918 1028 11p15.4 human T310-p 450869 GVGSVEQtPRKRLR_ protein degradation; molecular association, regulation SKP2(INDUCES) 12925736; 23421998 3 1 2 DN-Akt stabilized p57 +RGS19 RGS19 GAP; GAP, RGS P49795 10287 20q13.33 human S151-p 447873 EDYVSILsPKEVSLD RGS activity, induced 10993892; 15488168 2 1 0 +RUNX3 AML2 DNA-binding; Transcription factor Q13761 864 1p36.11 human K148-ub 11998601 VGRSGRGkSFTLTIT Runt protein degradation; intracellular localization transcription, inhibited 19808967 1 0 0 nuclear export +SCN8A SCN8A Channel, sodium; Membrane protein, integral; Membrane protein, multi-pass Q9UQD0 6334 12q13.13 human S561-p 1869659200 PFLSRHNsKSSIFSF Na_trans_cytopl activity, induced neural plasticity 32611770 1 1 0 Regulates voltage-gated sodium channel Nav1.6 activity and neuronal excitability +CYP3A4 CYP3A4 Cell surface; Cofactor and Vitamin Metabolism - retinol; EC 1.14.14.1; Lipid Metabolism - linoleic acid; Membrane protein, integral; Oxidoreductase; Xenobiotic Metabolism - drug metabolism - cytochrome P450; Xenobiotic Metabolism - drug metabolism - other enzymes; Xenobiotic Metabolism - metabolism by cytochrome P450 P08684 1576 7q22.1 human T264-p 5938005 KESRLEDtQKHRVDF p450 protein degradation; ubiquitination 19095658; 22101235; 25451919 3 2 0 +NFE2L2 NRF2 DNA-binding; Transcription factor Q16236 4780 2q31.2 human S408-p 10292700 GDMVQPLsPSQGQST activity, induced; protein degradation; protein stabilization; molecular association, regulation; ubiquitination; intracellular localization transcription, induced; transcription, inhibited; signaling pathway regulation BTRC(INDUCES); PIN1(INDUCES); FBW1B(INDUCES) 19668370; 31805502; 34918396; 37627580 4 5 0 +Cnr1 CNR1 GPCR, family 1; Membrane protein, integral; Membrane protein, multi-pass; Receptor, GPCR P47746 12801 4 A5|4 16.28 cM mouse S426-p 999609 TAQPLDNsMGDSDCL receptor desensitization, induced 24719095 3 4 0 +ANKRD55 ANKRD55 Unknown function Q3KP44 79722 5q11.2 human S436-p 1869465809 LPPIRTQsLPPITLG molecular association, regulation 14-3-3 beta(INDUCES) 31620119 0 1 0 +SENP3 SENP3 DESUMOYLASE; EC 3.4.22.68; Nucleolus; Protease; Sumo-specific protease Q9H4L4 26168 17p13.1 human S143-p 36438203 LLYSKSTsLTFHWKL molecular association, regulation; intracellular localization NPM1(INDUCES) 25288641 1 1 0 ribosome biogenesis-28S rRNA maturation +ARHGAP35 GRF-1 GAP; GAP, Rac/Rho; Motility/polarity/chemotaxis; Transcription factor; Tumor suppressor Q9NRY4 2909 19q13.32 human S296-p 14574213 NENWLSVsRKMQASP RhoGAP-FF1 molecular association, regulation eIF3-theta(INDUCES) 28007963 1 1 0 +CD151 CD151 Membrane protein, integral; Membrane protein, multi-pass P48509 977 11p15.5 human K8-ub 4666606 MGEFNEKkTTCGTVC protein degradation 18713730 1 2 0 cell surface downregulation of tetraspanins +PDGFRB PDGFRB EC 2.7.10.1; KINASE; Kinase, protein; Membrane protein, integral; Oncoprotein; Protein kinase, TK; Protein kinase, tyrosine (receptor) P09619 5159 5q32 human Y970-p 4833940 GEGYKKKyQQVDEEF enzymatic activity, induced cell motility, altered 19275932 1 2 0 in vitro +Pten PTEN Carbohydrate Metabolism - inositol phosphate; EC 3.1.3.16; EC 3.1.3.48; EC 3.1.3.67; Motility/polarity/chemotaxis; Nuclear receptor co-regulator; PHOSPHATASE; Phosphatase, lipid; Tumor suppressor O08586 19211 19 C1|19 28.14 cM mouse T366-p 449634 ASSSTSVtPDVSDNE protein stabilization cell growth, inhibited 20940307; 35603900 7 4 0 +G0s2 G0S2 Apoptosis; Mitochondrial Q61585 14373 1 H6|1 97.69 cM mouse K25-ub 56709106 KPRGKLVkLYVLGSV G0-G1_switch_2 protein degradation 27248498 1 0 0 +H4C1 H4 DNA-binding P62805 8359 6p22.2 human K91-ub 12106858 MDVVYALkRQGRTLY CENP-T_C DNA repair, induced; carcinogenesis, inhibited 19818714; 25605023 2 9 12 +Cdx2 CDX2 DNA-binding; Transcription factor P43241 12591 5 G3|5 86.86 cM mouse S60-p 460651 ANLDSAQsPGPSWPT Caudal_act transcription, inhibited 11729123; 21737780 3 0 0 regulates cell differentiation +UBB UBB Apoptosis; Cell cycle regulation; Cell development/differentiation; Motility/polarity/chemotaxis; Transcription regulation; Ubiquitin-like modifier P0CG47 7314 17p11.2 human T12-p 13302272 VKTLTGKtITLEVEP ubiquitin ubiquitination; intracellular localization cell growth, inhibited; DNA repair, inhibited 33022275 1 3 0 induces histone deubiquitination and inhibits p53 localization to chromatin further inhibiting NHEJ +EEF2 EEF2 Translation; Translation elongation P13639 1938 19p13.3 human Y265-p 457573 KKLWGDRyFDPANGK GTP_EFTU sumoylation 24648518 1 1 5 induces sumoylation at K322 and K529 +PPARGC1A PGC-1 alpha Nuclear receptor co-regulator; Transcription, coactivator/corepressor Q9UBK2 10891 4p15.2 human T299-p 448009 AGLTPPTtPPHKANQ protein stabilization 11741533 2 1 1 +Nolc1 NOLC1 Nucleolus; RNA-binding; Transcription, coactivator/corepressor P41777 64896 1q54 rat S113-p 455684 AAPAKRAsLPQHAGK activity, induced transcription, altered 12167624 1 5 0 +CAMK2A CAMK2A EC 2.7.11.17; KINASE; Kinase, protein; Protein kinase, CAMK; Protein kinase, Ser/Thr (non-receptor) Q9UQM7 815 5q32 human T306-p 449596 LKGAILTtMLATRNF molecular association, regulation; enzymatic activity, inhibited; intracellular localization NMDAR2B(DISRUPTS) 16436603; 21768120; 34391760 18 10 2 +Cited1 CITED1 Nuclear receptor co-regulator P97769 12705 X D|X 45.25 cM mouse S79-p 8112774 GSPTATPsSKPPSFN CITED intracellular localization cell differentiation, altered; cell differentiation, induced; transcription, altered 23529225; 25049079 2 0 0 nuclear translocation ALP2, RUNX2 and Osteocalcin gene expression altered; S63/64/65/67/69/73/79/80/84A mutation in CITED1 inhibits its translocation into the nucleus and osteoblasts differentiation +Eif4ebp1 4E-BP1 Translation; Translation initiation Q62622 116636 16q12.3 rat S111-p 447526 KRAGGEEsQFEMDI_ eIF_4EBP molecular association, regulation EIF4E(DISRUPTS) 11146653 5 15 28 +RAD51 RAD51 DNA repair, damage; Mitochondrial Q06609 5888 15q15.1 human K57-sm 1879760604 EAVAYAPkKELINIK molecular association, regulation DNA repair, induced BRCA2(INDUCES) 35061896 1 0 0 RAD51 SUMOylation is required for HR-mediated DSB repair, GFP-TOPORS-WT restored the interaction between RAD51 and BRCA2, but the T515A mutant restored to a lesser degree +Exoc8 EXOC8 Vesicle O54924 245709 19q12 rat S92-p 182950100 HLLTEQKsSLESIPL Vps51 molecular association, regulation exocytosis, inhibited Sec5(DISRUPTS); EXOC8(DISRUPTS) 28325821 1 1 0 +Irs2 IRS2 Adaptor/scaffold; Motility/polarity/chemotaxis P81122 384783 8 A1.1|8 5.35 cM mouse S1098-p 3217320 TSGLKRLsLMDQVSG protein degradation cell cycle regulation 25830382 1 7 0 +DRD2 DRD2 iso2 GPCR, family 1; Membrane protein, integral; Membrane protein, multi-pass; Receptor, GPCR P14416-2 1813 11q23.2 human S229-p 487433 RVNTKRSsRAFRAHL 7tm_1 receptor desensitization, induced; receptor recycling, induced 23082996 2 0 0 PKC mediated receptor desensitization and internalization +L1cam NCAM-L1 Cell adhesion; Membrane protein, integral Q05695 50687 Xq37 rat S1183-p 465573 GEYRSLEsDNEEKAF Bravo_FIGEY neural plasticity 33500315 6 23 5 +Cttn Cortactin Actin-binding; Cytoskeletal; Motility/polarity/chemotaxis Q60598 13043 7|7 F5 mouse Y334-p 450862 VVQVPSAyQKTVPIE cell cycle regulation; cell motility, altered 18515860 2 21 318 +PPP5C PPP5C EC 3.1.3.16; PHOSPHATASE; Protein phosphatase, Ser/Thr (non-receptor) P53041 5536 19q13.32 human K199-ub 41493185 KELMQWYkDQKKLHR PPP5 protein degradation; ubiquitination 29141220 1 4 0 +NFKB1 NFkB-p105 DNA-binding; Transcription factor P19838 4790 4q24 human K440-ac 465126 GTMDTESkKDPEGCD molecular association, regulation; intracellular localization DNA(INDUCES) 11739381 1 2 0 nuclear translocation +YAP1 YAP1 Oncoprotein; Transcription, coactivator/corepressor P46937 10413 11q22.1 human K280-sm 6094307 ISQSAPVkQPPPLAP protein stabilization; ubiquitination apoptosis, induced; transcription, induced 19111660 1 0 0 inhibits ubiquitination +Prkd1 PRKD1 Autophagy; EC 2.7.11.13; KINASE; Kinase, protein; Motility/polarity/chemotaxis; Protein kinase, CAMK; Protein kinase, Ser/Thr (non-receptor) Q62101 18760 12|12 B3 mouse S427-p 4960330 KHTKRRSsTVMKEGW intracellular localization; enzymatic activity, inhibited cell growth, inhibited; transcription, inhibited; signaling pathway regulation 24643961 2 1 3 +Dok3 DOK3 Adaptor/scaffold Q9QZK7 27261 13|13 B1 mouse Y343-p 454686 TGTAEHLyENVCMLE molecular association, regulation SHIP(INDUCES) 14993273 1 4 76 +Cnp CNP Cell development/differentiation; EC 3.1.4.37; Phosphodiesterase P13233 25275 10q31 rat K385-ac 4132177 RWMLSLAkKMEVKAI CNPase enzymatic activity, inhibited; protein conformation 34330062 1 1 1 +Sh3pxd2a Tks5 Adaptor/scaffold O89032 14218 19|19 C3 mouse S566-p 3199157 VPAFGFDsEPEMNEE cell cycle regulation; cell motility, altered 18515860 0 14 15 +HNRNPK hnRNP K RNA splicing; RNA-binding; Spliceosome P61978 3190 9q21.32 human K422-sm 2894422 HESGASIkIDEPLEG KH_1 protein stabilization; molecular association, regulation; ubiquitination; intracellular localization cell cycle regulation; transcription, induced MDM2(DISRUPTS); p53(INDUCES) DNA(INDUCES) 23092970 2 5 0 prevents ubiquitination +PLAU uPA EC 3.4.21.73; Motility/polarity/chemotaxis; Protease; Secreted; Secreted, signal peptide P00749 5328 10q22.2 human S323-p 451053 TGFGKENsTDYLYPE Trypsin molecular association, regulation; intracellular localization cell motility, altered; cell adhesion, altered; cytoskeletal reorganization ITGA5(INDUCES); ITGB5(INDUCES) 18844213; 9151681 3 0 0 reduces ITGB5/ITGA5 activation and its interaction with vitronectin and talin; ligand-dependent uPA redistribution severely impaired in a S158/323E mutant +NCL NCL DNA-binding; Helicase; Nuclear receptor co-regulator; Nucleolus; RNA-binding P19338 4691 2q37.1 human T84-p 9765542 PAKKAAVtPGKKAAA molecular association, regulation cell cycle regulation; cell growth, induced DDX31(INDUCES) 29440146; 37276927 2 14 6 +LRP1 LRP1 Cell surface; Membrane protein, integral; Motility/polarity/chemotaxis; Receptor, misc. Q07954 4035 12q13.3 human S4523-p 7103863 GSRHSLAsTDEKREL molecular association, regulation; receptor internalization, altered GULP1(INDUCES); DAB1(INDUCES); SHC1(INDUCES) 15272003 1 20 0 +PI4K2A PI4K2A EC 2.7.1.67; Kinase, lipid; Motility/polarity/chemotaxis Q9BTU6 55361 10q24.2 human S9-p 2022757 DETSPLVsPERAQPP endocytosis, inhibited 37314927 2 16 0 +ADD2 ADD2 Cytoskeletal; Motility/polarity/chemotaxis P35612 119 2p13.3 human S726-p 449803 KKKEKVEs_______ protein degradation; intracellular localization cytoskeletal reorganization 16116087; 9679146 2 0 0 +Id2 ID2 DNA-binding; Transcription, coactivator/corepressor P41137 25587 6q16 rat S5-p 451265 ___MKAFsPVRSVRK intracellular localization cell cycle regulation; transcription, altered; cell growth, altered 11706002 4 6 0 +WDR77 WDR77 Adaptor/scaffold; Nuclear receptor co-regulator; Transcription, coactivator/corepressor Q9BQA1 79084 1p13.2 human S264-p 17797201 CVTGLVFsPHSVPFL carcinogenesis, altered 20951943 1 1 0 in CCND1 T286A mutant +IRF8 IRF8 DNA-binding; Transcription factor Q02556 3394 16q24.1 human Y107-p 2299204 QLDISEPyKVYRIVP IRF transcription, inhibited 18195016 2 0 0 represses PTPN13 promoter activity +Dyrk1a DYRK1A EC 2.7.12.2; KINASE; Kinase, protein; Protein kinase, CMGC; Protein kinase, dual-specificity (non-receptor) Q63470 25255 11q11 rat Y321-p 448553 LGQRIYQyIQSRFYR Pkinase enzymatic activity, induced 11672423; 12604362; 8631952 5 145 3685 +GLIS2 GLIS2 C2H2-type zinc finger protein Q9BZE0 84662 16p13.3 human S245-p 17790902 PTCSKSFsRLENLKI zf-C2H2 molecular association, regulation; activity, inhibited transcription, inhibited DNA(DISRUPTS) 21127075 1 1 0 +Mastl MASTL EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, AGC; Protein kinase, Ser/Thr (non-receptor) Q8C0P0 67121 2|2 A3 mouse T297-p 1269647500 QCRKRLGtSSTSSQS activity, induced cell cycle regulation; signaling pathway regulation 30293837 2 0 0 inhibits pronuclei onset (PN onset) +MAP1LC3A LC3A Autophagy; Microtubule-binding; Ubiquitin-like modifier; Vesicle Q9H492 84557 20q11.22 human K49-ac 38557704 KQLPVLDkTKFLVPD ATG8 molecular association, regulation; intracellular localization autophagy, inhibited DOR-1(DISRUPTS); ATG7(DISRUPTS) 25601754 1 0 0 +Mapk14 P38A EC 2.7.11.24; KINASE; Kinase, protein; Protein kinase, CMGC; Protein kinase, Ser/Thr (non-receptor) P47811 26416 17 A3.3|17 14.85 cM mouse Y323-p 455799 DEPVADPyDQSFESR activity, induced; protein conformation; enzymatic activity, induced cell cycle regulation; cell growth, induced; signaling pathway regulation 19011223; 19324872; 21715315; 26517532 8 1 0 decreased IFN-gamma production in TCR-activated p38-alpha Y322F cells; ; in vitro; proliferation of p38-alpha Y322F T cells stimulated with anti-CD3/CD28, but not with PMA and ionomycin is delayed; dopaminergic neuronal cell death; p38 pathway activation, Induce T cell proliferation and Th Skewing, reduce autoimmunity and inflammation +TP53BP1 53BP1 DNA repair, damage; Transcription, coactivator/corepressor Q12888 7158 15q15.3 human R1401-me 2344817 TPRGRGRrGRPPSRT molecular association, regulation DNA(INDUCES) 16294045 2 0 0 +CENPT CENPT DNA replication Q96BT3 80152 16q22.1 human T195-p 459758 SLNLTFAtPLQPQSV CENP-T_N molecular association, regulation; intracellular localization cell cycle regulation 21529714; 25660545 2 2 1 localization of Ndc80/Hec1, controls kinetochore assembly, increases cell viability; KMN network recruitment +CSNK1A1 CK1A EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, CK1; Protein kinase, Ser/Thr (non-receptor) P48729 1452 5q32 human K8-ub 41484588 MASSSGSkAEFIVGG protein degradation 26909574 1 4 0 +Bcl10 Bcl-10 Apoptosis; Transcription, coactivator/corepressor; Tumor suppressor Q9Z0H7 12042 3|3 H2 mouse S138-p 470125 NNLSRCNsDESNLSE activity, induced; protein degradation 17502353 7 30 18 +KIF2C KIF2C Cancer Testis Antigen (CTA); Microtubule-binding; Motility/polarity/chemotaxis; Motor Q99661 11004 1p34.1 human S95-p 451107 IQKQKRRsVNSKIPA molecular association, regulation; intracellular localization; activity, inhibited cytoskeletal reorganization EB1(DISRUPTS) 14960279; 19632184 5 4 3 involved in microtubule tip tracking +Rhoq RHOQ G protein; G protein, monomeric; G protein, monomeric, Rho; Motility/polarity/chemotaxis Q8R527 104215 17 E4|17 56.9 cM mouse T189-p 5996401 ILTPKKHtVKKRIGS intracellular localization cytoskeletal reorganization 18948252 1 0 0 +HSP90AA1 HSP90A Chaperone; Heat shock protein P07900 3320 14q32.31 human R345-m1 57739897 RALLFVPrRAPFDLF HSP90 molecular association, regulation apoptosis, inhibited AHSA1(INDUCES) 31765670 1 2 0 +ERBB4 HER4 EC 2.7.10.1; KINASE; Kinase, protein; Membrane protein, integral; Protein kinase, TK; Protein kinase, tyrosine (receptor) Q15303 2066 2q34 human Y1202-p 4825105 PPKAEDEyVNEPLYL molecular association, regulation GRB2(INDUCES); Syk(INDUCES) 16729043; 18721752 1 1 1 +Csf1r CSFR EC 2.7.10.1; KINASE; Kinase, protein; Membrane protein, integral; Oncoprotein; Protein kinase, TK; Protein kinase, tyrosine (receptor) P09581 12978 18 E1|18 34.41 cM mouse Y544-p 2866400 KYKQKPKyQVRWKII enzymatic activity, induced cell differentiation, altered; cell growth, altered 18519746 4 0 0 +NUB1 NYREN18 Ubiquitin conjugating system Q9Y5A7 51667 7q36.1 human S46-p 1868140201 KDLAKQYsDRLECCE molecular association, regulation; activity, inhibited SNCA(INDUCES) 31006160 1 0 0 +OGG1 OGG1 DNA repair, damage; Deoxyribonuclease; EC 4.2.99.18; Lyase O15527 4968 3p25.3 human K341-ub 1877126900 AKRRKGSkGPEG___ enzymatic activity, inhibited DNA repair, induced 33282879 1 0 0 reduced cell survival in response to IR +MICAL1 MICAL1 Adaptor/scaffold; EC 1.14.13.-; Motility/polarity/chemotaxis Q8TDZ2 64780 6q21 human S817-p 5434440 SPERQRLsSLNLTPD molecular association, regulation cytoskeletal reorganization 14-3-3 epsilon(INDUCES); Rab7(INDUCES); RAB10(INDUCES) 36198272 1 3 27 +Cacna1b CACNA1B Channel, calcium; Membrane protein, integral; Membrane protein, multi-pass Q02294 257648 3p13 rat S896-p 455283 ERARPRRsHSKEAPG activity, inhibited 11312277 2 0 0 Phosphorylation by PKC prevents effects of syntaxin 1A on voltage dependent inactivation of N-type calcium channels. +CDK1 CDK1 Cell cycle regulation; EC 2.7.11.22; EC 2.7.11.23; KINASE; Kinase, protein; Motility/polarity/chemotaxis; Protein kinase, CMGC; Protein kinase, Ser/Thr (non-receptor) P06493 983 10q21.2 human Y4-p 473276 ____MEDyTKIEKIG Pkinase protein degradation; ubiquitination cell cycle regulation 20395957 1 2 4 +PRKAR2A PKAR2A Protein kinase, regulatory subunit P13861 5576 3p21.31 human S78-p 4702645 VADAKGDsESEEDED carcinogenesis, induced 36114575 3 59 47 +ASF1A ASF1A DNA repair, damage; Histone-binding Q9Y294 25842 6q22.31 human S166-p 3245981 KLEDAESsNPNLQSL molecular association, regulation; ubiquitination; intracellular localization; phosphorylation cell cycle regulation; DNA repair, induced; signaling pathway regulation MDC1(INDUCES) 33503415 2 11 2 induces H2AX, ATM, MDC1 phosphorylation, thus regulating H2A/X-ATM-MDC1-RNF8 signaling, resulting in 53BP1 localization and histone ubiquitination +EIF2AK3 PERK EC 2.7.11.1; KINASE; Kinase, protein; Membrane protein, integral; Protein kinase, Other; Protein kinase, Ser/Thr (non-receptor); Translation Q9NZJ5 9451 2p11.2 human T982-p 447936 MPAYARHtGQVGTKL Pkinase enzymatic activity, induced cell cycle regulation; carcinogenesis, inhibited; apoptosis, induced 14676213; 31906029; 34615996; 35331268 26 0 0 +Rhoa RHOA G protein; G protein, monomeric; G protein, monomeric, Rho; Motility/polarity/chemotaxis; Oncoprotein Q9QUI0 11848 9|9 F1-F2 mouse S188-p 449035 ARRGKKKsGCLIL__ activity, inhibited transcription, altered; transcription, inhibited 15102857; 19737918 17 0 0 +YAP1 YAP1 Oncoprotein; Transcription, coactivator/corepressor P46937 10413 11q22.1 human Y188-p 56813400 KTSSGQRyFLNHIDQ WW activity, induced; molecular association, regulation; intracellular localization carcinogenesis, induced; cell motility, induced; cell growth, induced LATS1(DISRUPTS); PTPN14(DISRUPTS) 27428284 1 1 0 +Pld2 PLD2 EC 3.1.4.4; Lipid Metabolism - ether lipid; Lipid Metabolism - glycerophospholipid; Motility/polarity/chemotaxis; Phospholipase P97813 18806 11 B3|11 42.99 cM mouse Y165-p 453411 HTASKQKyLENYLNR PX intracellular localization; phosphorylation; enzymatic activity, induced 15282299 1 0 0 +Rps6kb1 p70S6K EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, AGC; Protein kinase, Ser/Thr (non-receptor); Translation P67999 83840 10q26 rat T412-p 448607 NQVFLGFtYVAPSVL Pkinase_C enzymatic activity, induced 11516946; 11705993; 11861821; 15774499; 17220300; 36224569; 9632736 476 9 1 +PML PML iso3 Nucleolus; Oncoprotein; SUMO LIGASE; SUMO conjugating system; SUMO ligase; Transcription factor; Tumor suppressor; Ubiquitin conjugating system P29590-3 5371 15q24.1 human S117-p 455494 ESLQRRLsVYRQIVD apoptosis, induced 12402044 1 0 0 +FZR1 FZR1 UBIQUITIN LIGASE; Ubiquitin conjugating system Q9UM11 51343 19p13.3 human S40-gl 55596602 PASSPVSsPSKHGDR activity, induced; molecular association, regulation CDC27(INDUCES) 27080259 1 1 0 promotes the interaction between FZR1 and APC/C subunits, enhances APC/C activity +LTF LTF EC 3.4.21.-; Protease; Secreted; Secreted, signal peptide P02788 4057 3p21.31 human S54-gl 13421408 KVRGPPVsCIKRDSP Transferrin protein stabilization transcription, inhibited 20404350 1 0 0 blocking ubiquitin dependent proteolysis +Mapt Tau ACETYLTRANSFERASE; Acetyltransferase; Cytoskeletal P10637 17762 11 67.79 cM|11 E1 mouse K466-ac 55529800 NATRIPAkTTPSPKT protein stabilization; intracellular localization transcription, induced; translation, induced 33910019 5 1 0 increases protein synthesis, K174ac nuclear accumulation, induces rDNA relaxation, nucleolar expansion +DOK2 DOK2 Adaptor/scaffold O60496 9046 8p21.3 human Y139-p 449649 CMEENELySSAVTVG molecular association, regulation DOK2(INDUCES); DOK1(INDUCES) 16177091 2 5 107 Dok1/Dok2 oligomerization required for ERK1/2 and NFAT activation +Per2 PER2 Nuclear receptor co-regulator; Nucleolus; Transcription factor O54943 18627 1|1 D mouse S659-p 449331 TLPGKAEsVVSLTSQ protein degradation; protein stabilization; intracellular localization 16983144; 26431025 8 1 1 two competing phosphorylation sites determine whether PER2 has a fast or slow degradation rate, regulated by temperature +Smtnl1 SMTNL1 Q99LM3 68678 2|2 D mouse S301-p 2755200 RAPERRVsAPSRPRG molecular association, regulation; activity, inhibited TPM1(INDUCES); Calmodulin(DISRUPTS) 18310078; 28320308 3 1 0 +ALDH1B1 ALDH1B1 Amino Acid Metabolism - arginine and proline; Amino Acid Metabolism - histidine; Amino Acid Metabolism - lysine degradation; Amino Acid Metabolism - tryptophan; Amino Acid Metabolism - valine, leucine and isoleucine degradation; Carbohydrate Metabolism - ascorbate and aldarate; Carbohydrate Metabolism - butanoate; Carbohydrate Metabolism - glycolysis and gluconeogenesis; Carbohydrate Metabolism - propanoate; Carbohydrate Metabolism - pyruvate; EC 1.2.1.3; Lipid Metabolism - fatty acid; Lipid Metabolism - glycerolipid; Mitochondrial; Other Amino Acids Metabolism - beta-alanine; Oxidoreductase; Secondary Metabolites Metabolism - limonene and pinene degradation P30837 219 9p13.1 human K506-ub 1881380901 LKAYTEVkTVTIKVP molecular association, regulation transcription, inhibited ALDH1B1(DISRUPTS) 34769507 1 0 0 AMBRA1-mediated ubiquitylation of ALDH1B1 inhibitss the self-association of ALDH1B1 and the transcription of PTEN +SIAH1 SIAH1 Apoptosis; Cell development/differentiation; EC 6.3.2.-; EC 6.3.2.19; Ligase; Motility/polarity/chemotaxis; UBIQUITIN LIGASE; Ubiquitin conjugating system; Ubiquitin ligase Q8IUQ4 6477 16q12.1 human T239-p 36694105 RRLTWEAtPRSIHEG Sina molecular association, regulation; acetylation; intracellular localization signaling pathway regulation GAPDH(INDUCES) 25391652 1 0 0 augments p300 acetylation; nuclear translocation +H3C1 H3 DNA-binding P68431 8350 6p22.2 human T3-p 455678 _____ARtKQTARKS Histone molecular association, regulation; enzymatic activity, inhibited; intracellular localization cell cycle regulation; chromatin organization, altered; cytoskeletal reorganization; transcription, inhibited; signaling pathway regulation TAF140(DISRUPTS); PHF21A(DISRUPTS); JMJD2A(DISRUPTS); ING2(DISRUPTS); RAG2(DISRUPTS); Survivin(INDUCES); AIRE(DISRUPTS) 15846065; 17084365; 17938195; 19187761; 20190764; 20705812; 20929775; 20953165; 21658950; 21820363 23 2 0 +Pou5f1 Oct4 DNA-binding; Transcription factor P20263 18999 17 B1|17 18.69 cM mouse K133-ub 15395132 PEESQDMkALQKELE protein degradation 32895487 1 0 1 +CD19 CD19 Cell surface; Membrane protein, integral P15391 930 16p11.2 human Y500-p 447638 TSLGSQSyEDMRGIL molecular association, regulation LYN(INDUCES); PIK3CA(INDUCES); VAV1(INDUCES) 10933394 6 4 15 +WWTR1 TAZ Oncoprotein; Transcription, coactivator/corepressor Q9GZV5 25937 3q25.1 human T346-p 41594202 TGENAGQtPMNINPQ protein degradation; activity, inhibited carcinogenesis, inhibited; cell growth, inhibited; cell motility, inhibited; transcription, inhibited 26183396; 26375055 2 0 0 +H3c1 H3 DNA-binding P68433 360198 13|13 A3.1 mouse K4-m2 459004 ____ARTkQTARKST Histone methylation cell differentiation, induced; chromatin organization, altered; transcription, induced; transcription, inhibited 16682010; 17488778; 17493269; 17967893; 18039862; 18927235; 19707598; 20067909; 20393567; 20395309; 20574709; 23362347; 29370269 108 10 0 +FLT3 FLT3 EC 2.7.10.1; KINASE; Kinase, protein; Membrane protein, integral; Oncoprotein; Protein kinase, TK; Protein kinase, tyrosine (receptor) P36888 2322 13q12.2 human R973-m2 1879733101 PHTYQNRrPFSREMD molecular association, regulation carcinogenesis, induced; cell growth, induced; apoptosis, inhibited GRB2(INDUCES); Btk(NOT_REPORTED); SHP-2(INDUCES) 31217189; 31395602 2 2 0 +Per2 PER2 Nuclear receptor co-regulator; Nucleolus; Transcription factor O54943 18627 1|1 D mouse S662-p 470017 GKAESVVsLTSQCSY phosphorylation 29784789 3 1 1 induces phosphorylation of S662 and further regulating the circadian clock +CDC25A CDC25A EC 3.1.3.48; Motility/polarity/chemotaxis; PHOSPHATASE; Protein phosphatase, dual-specificity P30304 993 3p21.31 human S107-p 31086927 NPMRRIHsLPQKLLG M-inducer_phosp protein degradation; ubiquitination cell cycle regulation; apoptosis, inhibited 34363019 1 3 0 +Hoxb9 HOXB9 DNA-binding P20615 15417 11 D|11 59.81 cM mouse T133-p 31087958 GELLKQGtPEYSLET Hox9_act protein degradation; ubiquitination carcinogenesis, inhibited; cell motility, inhibited; transcription, inhibited; signaling pathway regulation 36001969 1 2 0 regulates the AMPK-HOXB9-KRAS pathway +Slc12a5 KCC2 iso2 Membrane protein, integral; Membrane protein, multi-pass; Transporter; Transporter, SLC family Q91V14-2 57138 2|2 H3 mouse S940-p 487533 ITDESRGsIRRKNPA SLC12 activity, induced; protein stabilization neural plasticity; endocytosis, inhibited 21532577; 22171026; 25546454; 25733865; 31396048; 31806759; 32427585 23 5 2 +DGCR8 DGCR8 Nucleolus; RNA processing; RNA-binding Q8WYQ5 54487 22q11.21 human S377-p 3208083 LTPSGDVsPVKPLSR protein stabilization 24239349 1 43 4 +CLOCK CLOCK ACETYLTRANSFERASE; Acetyltransferase; DNA-binding; EC 2.3.1.48; Transcription factor O15516 9575 4q12 human S434-p 12059703 SPTPSASsRSSRKSS protein degradation 19946213 1 0 0 +IL16 IL16 Cytokine; DNA-binding; Motility/polarity/chemotaxis Q14005 3603 15q25.1 human T757-p 11280303 TQGHPDGtPPKLDTA intracellular localization cell cycle regulation 12450396 1 0 0 regulate nuclear localization +SLC6A4 SERT Membrane protein, integral; Membrane protein, multi-pass; Transporter P31645 6532 17q11.2 human Y47-p 21697923 SGQISNGySAVPSPG 5HT_transport_N activity, induced; protein stabilization 21992875 1 0 1 increases 5-HT uptake +FOXO4 FOXO4 DNA-binding; Oncoprotein; Transcription factor P98177 4303 Xq13.1 human T32-p 455572 QSRPRSCtWPLPRPE intracellular localization transcription, inhibited 16272144 6 8 34 +CD79A Ig-alpha Immunoglobulin superfamily; Membrane protein, integral P11912 973 19q13.2 human Y210-p 447752 SRGLQGTyQDVGSLN molecular association, regulation NCK1(INDUCES) 23913047 6 5 30 Akt activation +TPD52 TPD52 Calcium-binding; Endoplasmic reticulum P55327 7163 8q21.13 human S40-p 17555377 GNSSPPGsPTLQKFG protein stabilization; molecular association, regulation carcinogenesis, induced; cell motility, induced; cell growth, induced SPOP(DISRUPTS) 35194188 1 3 0 inhibits ubiquitination +NLRP3 NLRP3 Inhibitor Q96P20 114548 1q44 human S806-p 1877558200 KLVELDLsDNALGDF LRR_6 molecular association, regulation NEK7(DISRUPTS); BRCC3(DISRUPTS) 34615873 1 1 0 induces deubiquitination +SCNN1B ENaC-beta Channel, sodium; Membrane protein, integral; Membrane protein, multi-pass; Transporter, ion channel P51168 6338 16p12.2 human T615-p 451219 QALPIPGtPPPNYDS ubiquitination endocytosis, induced 28588583 6 1 0 +NCAPH2 NCAPH2 Cell cycle regulation; Endoplasmic reticulum; Membrane protein, integral Q6IBW4 29781 22q13.33 human S288-p 36136891 ESRSPQQsAALPRRY cell cycle regulation 28717250 1 1 0 required for mitotic chromosome segregation +NFE2L2 NRF2 DNA-binding; Transcription factor Q16236 4780 2q31.2 human K445-ac 7106316 KTPFTKDkHSSRLEA molecular association, regulation transcription, induced DNA(INDUCES) 19273602 1 1 0 +CDKN2A p16-INK4A Cell cycle regulation; Nucleolus; Tumor suppressor P42771 1029 9p21.3 human S7-p 448829 _MEPAAGsSMEPSAD protein stabilization 21270107 3 0 0 +Dpysl2 CRMP-2 Microtubule-binding; Motility/polarity/chemotaxis P47942 25416 15p12 rat K374-sm 31094501 DKAVVTGkMDENQFV Amidohydro_1 sumoylation endocytosis, induced 27940916 6 0 0 +RACK1 RACK1 Adaptor/scaffold; G protein; G protein, heterotrimeric; G protein, heterotrimeric beta; Motility/polarity/chemotaxis; Nuclear receptor co-regulator P63244 10399 5q35.3 human S146-p 999602 KYTVQDEsHSEWVSC WD40 protein conformation 17965024 1 0 0 S146 phosphoirylation promotes dimerization of RACK1 and degredation of HIF-1 alpha. +PDGFRA PDGFRA EC 2.7.10.1; KINASE; Kinase, protein; Membrane protein, integral; Oncoprotein; Protein kinase, TK; Protein kinase, tyrosine (receptor) P16234 5156 4q12 human Y572-p 448437 ISPDGHEyIYVDPMQ molecular association, regulation Src(INDUCES) 9454734 2 6 16 +SHC3 SHC3 Adaptor/scaffold; Motility/polarity/chemotaxis Q92529 53358 9q22.1 human Y341-p 451254 GDGSDHPyYNSIPSK apoptosis, inhibited 12242309 3 1 3 +PCBP2 hnRNP E2 RNA splicing; RNA-binding Q15366 5094 12q13.13 human S272-p 482918 FSGIESSsPEVKGYW protein stabilization; molecular association, regulation cell differentiation, inhibited; translation, inhibited RNA(INDUCES) 17475908 1 19 8 +LATS1 LATS1 EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, AGC; Protein kinase, Ser/Thr (non-receptor); Tumor suppressor O95835 9113 6q25.1 human S909-p 457594 HQRCLAHsLVGTPNY Pkinase protein degradation; intracellular localization; phosphorylation; enzymatic activity, induced cell cycle regulation; carcinogenesis, induced; carcinogenesis, inhibited; apoptosis, induced; cell growth, inhibited; signaling pathway regulation; cell growth, induced; transcription, inhibited 15688006; 29934311; 31239271; 35307353; 35731019; 35882980; 36115593; 36622276; 37319316 32 5 15 +XBP1 XBP1 DNA-binding; Transcription factor P17861 7494 22q12.1|22q12 human K60-ub 1878023502 GGLPQARkRQRLTHL protein degradation; ubiquitination; intracellular localization transcription, inhibited 31837300 1 0 0 K60/77R enhances the nuclear localization, enhances insulin sensitivity in the hepatocyte and in db/db mice, maintains glucose homeostasis in DIO mice, alleviates ER stress in DIO mice, increases its protein abundance, transcriptional activity +FLT1 VEGFR1 EC 2.7.10.1; KINASE; Kinase, protein; Membrane protein, integral; Protein kinase, TK; Protein kinase, tyrosine (receptor) P17948 2321 13q12.3 human K831-me 4061500 RERLKLGkSLGRGAF PK_Tyr_Ser-Thr phosphorylation; enzymatic activity, induced 18006819 1 0 0 enhances VEGFR1 autophosphorylation +TFAM TFAM DNA-binding; Transcription regulation Q00059 7019 10q21.1 human K52-ac 1876567508 VLASCPKkPVSSYLR HMG_box transcription, induced 35278431 0 1 0 +SPIN1 SPIN1 DNA-binding; Nucleolus Q9Y657 10927 9q22.1 human T120-p 471338 VLPDRVAtSRISDAH protein stabilization; protein conformation cell cycle regulation 17082182 1 0 0 +Syn1 SYN1 Vesicle P09951 24949 Xq11 rat S62-p 451572 STAAPVAsPAAPSPG neural plasticity; signaling pathway regulation 31493733; 33519375; 35723394 20 9 0 +Sstr2 SSTR2 GPCR, family 1; Membrane protein, integral; Membrane protein, multi-pass; Receptor, GPCR P30875 20606 11 E2|11 79.05 cM mouse Y312-p 450820 SCANPILyAFLSDNF 7tm_1 molecular association, regulation SHP-2(INDUCES) 12972574 1 0 0 +ELAVL1 HuR RNA-binding Q15717 1994 19p13.2 human K326-ub 31006100 FKTNKSHk_______ molecular association, regulation RNA stability, inhibited ETEA(INDUCES) RNA(DISRUPTS) 23618873 1 0 0 +FOXO3 FOXO3A Autophagy; DNA-binding; Oncoprotein; Transcription factor O43524 2309 6q21 human S7-p 9318032 _MAEAPAsPAPLSPL activity, induced; intracellular localization; phosphorylation cell cycle regulation 22128155; 26376801 2 22 19 +CAMKK1 CAMKK1 EC 2.7.11.17; KINASE; Kinase, protein; Protein kinase, Other; Protein kinase, Ser/Thr (non-receptor) Q8N5S9 84254 17p13.2 human S74-p 452115 SLSARKLsLQERPAG molecular association, regulation; enzymatic activity, inhibited; enzymatic activity, induced 14-3-3 eta(INDUCES) 11574071; 18242179 4 19 8 14-3-3 inhibits CAMKK1 activity. ; activity toward PKIV peptide; replacement of S74 to A or D caused an increase in the enzyme activity +FLT1 VEGFR1 EC 2.7.10.1; KINASE; Kinase, protein; Membrane protein, integral; Protein kinase, TK; Protein kinase, tyrosine (receptor) P17948 2321 13q12.3 human Y1213-p 448209 GSSDDVRyVNAFKFM molecular association, regulation; enzymatic activity, induced GRB2(INDUCES); PLCG1(INDUCES); SHP-2(INDUCES) 11583921; 9722576 4 0 7 +Bcar1 P130Cas Adaptor/scaffold; Motility/polarity/chemotaxis Q63767 25414 19q12 rat Y347-p 448721 APGSQDIyDVPPVRG cell motility, altered 12972425 14 44 723 +KLF11 TIEG2 C2H2-type zinc finger protein; DNA-binding; Transcription factor O14901 8462 2p25.1 human S111-p 456009 LCITPPQsPDLVEPS molecular association, regulation SIN3A(DISRUPTS) 12006497 1 1 0 +MCL1 MCL1 Apoptosis; Channel, misc.; Inhibitor; Membrane protein, integral; Mitochondrial Q07820 4170 1q21.2 human K197-ub 10837359 ATGAKDTkPMGRSGA protein degradation 28522751 4 5 27 +SLC25A5 SLC25A5 Membrane protein, integral; Membrane protein, multi-pass; Mitochondrial; Transporter; Transporter, SLC family P05141 292 Xq24 human K105-ac 461136 IFLGGVDkRTQFWLY protein degradation; phosphorylation 32194820 1 9 107 reciprocal regulation of T107, K105 +Fzd3 FZD3 GPCR, Fz/Smo family; Membrane protein, integral; Membrane protein, multi-pass; Receptor, GPCR Q61086 14365 14 D1|14 34.09 cM mouse T563-p 18507001 TSTHASStQLAMVDD receptor internalization, inhibited; phosphorylation endocytosis, inhibited 21316586 1 0 0 enhances PCP signaling, regulating c-Jun phosphorylation, and affecting growth cone guidance +EIF2B5 eIF2B-epsilon Translation; Translation initiation Q13144 8893 3q27.1 human S540-p 449905 MDSEEPDsRGGSPQM signaling pathway regulation; translation, inhibited 22231169 10 3 0 +CCNF CCNF Cell cycle regulation P41002 899 16p13.3 human S577-p 234613503 TKRKRENsLQEDRGS protein stabilization cell cycle regulation 28954236 2 2 0 cell-cycle progression +UCK1 UCK1 EC 2.7.1.48; Kinase, other; Nucleotide Metabolism - pyrimidine; Xenobiotic Metabolism - drug metabolism - other enzymes Q9HA47 83549 9q34.13 human K81-ub 27213910 EQKAKALkGQYNFDH PRK protein degradation 31938050 1 5 0 +HSP90AB1 HSP90B Chaperone; Heat shock protein P08238 3326 6p21.1 human K286-ac 36304638 QEELNKTkPIWTRNP HSP90 molecular association, regulation; intracellular localization; activity, inhibited transcription, induced; signaling pathway regulation HIF1A(DISRUPTS); HIF2A(DISRUPTS) 28915577 1 1 0 HIF signaling +PPP2R2B PPP2R2B iso2 Apoptosis; Mitochondrial; Motility/polarity/chemotaxis; Protein phosphatase, regulatory subunit Q00005-2 5521 5q32 human S20-p 25554903 RPPNTILsSSCHTEA intracellular localization; phosphorylation apoptosis, inhibited 22583914 1 0 0 induces phosphorylation of Drp1 and regulates mitochondrial fragmentation and OMM translocation of beta B2 +PRKG1 PKG1 EC 2.7.11.12; KINASE; Kinase, protein; Protein kinase, AGC; Protein kinase, Ser/Thr (non-receptor) Q13976 5592 10q11.23-q21.1 human T59-p 1870119330 THIGPRTtRAQGISA enzymatic activity, induced 12609995 1 0 0 +POLG POLG DNA repair, damage; DNA replication; EC 2.7.7.7; Mitochondrial; Transferase P54098 5428 15q26.1 human K1060-ub 21181880 TESEMFNkLESIATS DNA_pol_A protein degradation; molecular association, regulation; intracellular localization; enzymatic activity, inhibited TOM20(DISRUPTS) 33657094 1 2 0 ubiquitylated POLG cannot enter mitochondria +TPT1 TPT1 Calcium-binding; Microtubule-binding P13693 7178 13q14.13 human K19-ac 33348800 EMFSDIYkIREIADG TCTP protein degradation HSC70(INDUCES) 28110910 1 2 0 +GRK2 GRK2 EC 2.7.11.15; KINASE; Kinase, protein; Protein kinase, AGC; Protein kinase, Ser/Thr (non-receptor) P25098 156 11q13.2 human S670-p 447725 KMKNKPRsPVVELSK protein degradation; acetylation; molecular association, regulation; ubiquitination; phosphorylation cell cycle regulation; chromatin organization, altered; cell motility, induced; cell adhesion, induced; cytoskeletal reorganization; cell growth, altered PIN1(INDUCES) 20080565; 22193721; 33806062 5 40 18 induces deacetylation of TUBA1A at K40 via HDAC6 phosphorylation; induces MST2 phosphorylation +Eef1a1 EEF1A1 Nucleolus; Translation; Translation elongation P62630 171361 8q31 rat K165-m2 3898709 TEPPYSQkRYEEIVK GTP_EFTU molecular association, regulation translation, altered EEF1D(DISRUPTS); eEF1B(DISRUPTS); EEF1G(DISRUPTS) 28108655 1 7 12 +WIPF1 WIPF1 Actin-binding; Motility/polarity/chemotaxis O43516 7456 2q31.1 human T398-p 14582886 TSRALPAtPQLPSRS cell growth, induced 28166194 1 12 7 +IRF3 IRF3 DNA-binding; Transcription factor Q14653 3661 19q13.33 human K366-m1 1873286920 TKRLVMVkVVPTCLR IRF-3 molecular association, regulation; phosphorylation transcription, induced PPP1CC(DISRUPTS) 29101251 1 1 0 induces antiviral innate immune response +STK38 NDR1 EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, AGC; Protein kinase, Ser/Thr (non-receptor) Q15208 11329 6p21.31 human S11-p 22553320 TGSTPCSsMSNHTKE enzymatic activity, inhibited; phosphorylation signaling pathway regulation 22142472 1 0 0 primes phosphorylation at S6 and T7, induces JNK phosphorylation, regulates cell death through JNK signaling +Ptpn2 PTPN2 EC 3.1.3.48; Motility/polarity/chemotaxis; PHOSPHATASE; Protein phosphatase, tyrosine (non-receptor) Q06180 19255 18|18 E1 mouse T179-p 397383601 ISHFHYTtWPDFGVP Y_phosphatase molecular association, regulation; intracellular localization apoptosis, induced STAT3(INDUCES) 29207596 1 1 0 nuclear translocation +Ahcyl1 AHCYL1 Amino Acid Metabolism - cysteine and methionine; EC 3.3.1.1; Hydrolase; Other Amino Acids Metabolism - selenoamino acid Q80SW1 229709 3 F2.3|3 46.83 cM mouse S70-p 467247 LSRSISQsSTDSYSS molecular association, regulation PIP5K1A(INDUCES); IP3R1(INDUCES) 16793548; 26509711 2 0 0 +Camsap1 CAMSAP1 Unknown function A2AHC3 227634 2|2 A3 mouse S1464-p 1869962002 PIIHNAIsHCCLAGK CAMSAP_CKK cell differentiation, induced; cytoskeletal reorganization 32839317 1 1 0 +Neurod1 NEUROD1 DNA-binding; Transcription factor Q60867 18012 2 C3|2 47.58 cM mouse S162-p 465677 EILRSGKsPDLVSFV Neuro_bHLH transcription, induced 12810726 1 0 0 +TUT1 RBM21 EC 2.7.7.19; EC 2.7.7.52; Nucleolus; Transferase Q9H6E5 64852 11q12.3 human S6-p 31080908 __MAAVDsDVESLPR molecular association, regulation transcription, induced; translation, induced RBM21(INDUCES) RNA(INDUCES) 26138484; 29203642 2 6 0 CDH1, CDH13, KISS1R, NME1, WIF1 wound healing +HTT Huntingtin Cytoskeletal P42858 3064 4p16.3 human S429-p 2020877 ELIAGGGsSCSPVLS protein degradation 22623107 2 9 2 increased cell viability and reduced protein accumulation in S429A mutant +TCF3 E2A Cell development/differentiation; DNA-binding; Oncoprotein; Transcription factor P15923 6929 19p13.3 human K34-ac 25218500 PLPVTNGkGRPASLA molecular association, regulation transcription, induced p300(INDUCES); CBP(INDUCES) 22207202 1 0 0 +TP53 p53 Activator; DNA-binding; Motility/polarity/chemotaxis; Nuclear receptor co-regulator; Transcription factor; Tumor suppressor P04637 7157 17p13.1 human R333-me 5009203 EYFTLQIrGRERFEM P53_tetramer cell cycle regulation; apoptosis, inhibited; transcription, altered 53BP1(INDUCES) 19011621 1 1 0 PRMT5 enhanced p53-dependent cell-cycle arrest; after treatment with PRMT5 theere was a reduction in dimer and tetramer formation; arginine methylation affects the promoter specificity of p53 +LAIR1 LAIR-1 Membrane protein, integral; Receptor, misc. Q6GTX8 3903 19q13.42 human Y281-p 449313 PMAESITyAAVARH_ molecular association, regulation SHP-1(INDUCES) 10764762 2 6 332 +Maf MAF Cell development/differentiation; DNA-binding; Oncoprotein; Transcription factor; Tumor suppressor P54843 17132 8 E1|8 62.61 cM mouse Y131-p 25673103 LQGGFDGyARGAQQL molecular association, regulation transcription, induced DNA(INDUCES) 25993510 2 0 0 IL-4 and IL-21 induction +NR3C1 GR DNA-binding; Mitochondrial; Nuclear receptor; Transcription factor P04150 2908 5q31.3 human K293-sm 2532300 LCTPGVIkQEKLGTV GCR protein degradation transcription, induced; transcription, inhibited 12144530; 12193561; 26712006 7 3 0 +Slc12a5 KCC2 iso2 Membrane protein, integral; Membrane protein, multi-pass; Transporter; Transporter, SLC family Q63633-2 171373 3q42 rat T934-p 33623802 EREIQSItDESRGSI SLC12 activity, induced; protein conformation 24849604 3 0 0 increase transport kinetics of KCC2 +Ankrd54 ANKRD54 Cell cycle regulation Q91WK7 223690 15 E1|15 37.7 cM mouse S14-p 239773904 GADDESRsGRSSSDG molecular association, regulation; intracellular localization LYN(INDUCES) 28924458 1 1 0 nuclear export, cytoplasmic accumulation +Cacna1c CACNA1C Channel, calcium; Membrane protein, integral; Membrane protein, multi-pass P22002 24239 4q42 rat Y2148-p 450658 PEDESCVyALGRGRS activity, induced; molecular association, regulation ITGB1(INDUCES) 10939336; 16554304; 21178109 3 0 0 +SP1 SP1 C2H2-type zinc finger protein; DNA-binding; Transcription factor P08047 6667 12q13.13 human K703-ac 12718501 MRSDHLSkHIKTHQN zf-C2H2 molecular association, regulation; acetylation transcription, inhibited p300(DISRUPTS) 16478997 3 0 0 inhibits acetylation of histone 3 by inhibiting recruitiment of p300 to the promoter +GHR GH receptor Membrane protein, integral; Receptor, cytokine P19941 100009325 rabbit Y595-p 450480 SEMPVPDyTSIHLVQ GHBP molecular association, regulation SOCS2(INDUCES); CISH(INDUCES) 17666591 3 1 0 +Kmt2a MLL Cell cycle regulation; EC 2.1.1.43; METHYLTRANSFERASE; Methyltransferase; Methyltransferase, protein lysine; Oncoprotein; Transcription factor P55200 214162 9 A5.2|9 24.84 cM mouse K1130-ac 40493901 APPIKPIkPVTRNKA transcription, induced 25751424 1 0 0 +Lipe HSL EC 3.1.1.79; Lipase P15304 25330 1q21 rat S863-p 448803 LTESMRRsVSEAALA enzymatic activity, induced transcription, induced 28716938; 9636039 41 11 2 regulation of steroidogenesis +Tnni3 TNNI3 Actin-binding; Motility/polarity/chemotaxis; Motor P48787 21954 7 A1|7 2.61 cM mouse T144-p 451483 RGKFKRPtLRRVRIS Troponin activity, induced; activity, inhibited; protein conformation; phosphorylation cytoskeletal reorganization; signaling pathway regulation 12923217; 15774859; 17010989; 19426736; 22527640; 24772522 29 2 1 regulates contractibility of cardiac myocytes; ROCK II induced desensitization to Ca++ and depression in maximal tension. +MZF1 MZF-1 C2H2-type zinc finger protein; DNA-binding; Transcription factor P28698 7593 19q13.43 human S27-p 50784428 VMVKLEDsEEEGEAA activity, induced; molecular association, regulation carcinogenesis, induced; transcription, induced; signaling pathway regulation CTCF(DISRUPTS) 30622337 1 3 0 +Mcm4 MCM4 DNA replication; EC 3.6.4.12 P49717 17217 16 A2|16 10.09 cM mouse T19-p 448634 SSRRGRVtPTQSLRS activity, inhibited 11454864 3 21 16 Phosphorylation of T19 correlates with lowered level of DNA helicase activity of the purified Mcm4,6,7 complex. +RIGI RIGI EC 3.6.4.13; Hydrolase O95786 23586 9p21.1 human T170-p 12613700 DKENWPKtLKLALEK CARD_2 molecular association, regulation; ubiquitination; protein conformation transcription, induced; transcription, inhibited NPL4(DISRUPTS); TRIM25(DISRUPTS); MAVS(DISRUPTS) 20071582; 22114345; 23063562; 23264040; 26471729; 28250012 9 1 0 +P2RX3 P2X3 Channel, ligand-gated; Membrane protein, integral; Membrane protein, multi-pass P56373 5024 11q12.1 human S269-p 458894 FTRLDSVsEKSSVSP P2X_receptor receptor desensitization, altered 16226373 1 0 0 +AKAP12 AKAP12 Adaptor/scaffold Q02952 9590 6q25.1 human S698-p 455890 RARRGSSsDEEGGPK receptor desensitization, inhibited; molecular association, regulation ADRB2(INDUCES) 14657015 1 20 35 +Cacnb2 CACNB2 Channel, calcium Q8VGC3 116600 17q12.3 rat T549-p 470081 RGLSRQEtFDSETQE activity, induced 16949361 5 8 30 increases the probability of channel being open (facilitation) +Gabbr2 GABBR2 GPCR, family 3; Membrane protein, integral; Membrane protein, multi-pass; Receptor, GPCR Q80T41 242425 4|4 B1 mouse S892-p 450809 EHIQRRLsLQLPILH receptor desensitization, inhibited; molecular association, regulation; protein conformation; phosphorylation KCTD12(INDUCES) 25065880 6 1 0 Binding of KCTD12 to GABBR2 increases S892 phosphorylation. +Pklr PKLR iso2 Carbohydrate Metabolism - glycolysis and gluconeogenesis; Carbohydrate Metabolism - pyruvate; EC 2.7.1.40; Kinase, other; Nucleotide Metabolism - purine P12928-2 24651 2q34 rat S113-p 31084572 ATESFATsPLSYRPV PK intracellular localization 31825824 1 2 0 suppresses glucose production +TNNI3 TNNI3 Actin-binding; Motility/polarity/chemotaxis; Motor P19429 7137 19q13.42 human T143-p 451483 RGKFKRPtLRRVRIS Troponin activity, induced; molecular association, regulation; activity, inhibited; protein conformation TNNC1(DISRUPTS); C16orf82(INDUCES); TNC(INDUCES) 12044157; 18986304; 24116014; 24585778 29 2 1 reduced maximal force generation; induces Ca2+ sensitivity myofilaments without affecting LDA +KATNA1 KATNA1 EC 3.6.4.3; Hydrolase; Motility/polarity/chemotaxis O75449 11104 6q25.1 human T133-p 26401201 HGNRPSTtVRVHRSS ubiquitination cell cycle regulation 19287380 1 0 0 +Mapk7 ERK5 EC 2.7.11.24; KINASE; Kinase, protein; Protein kinase, CMGC; Protein kinase, Ser/Thr (non-receptor) Q9WVS8 23939 11|11 B2 mouse S486-p 450251 LKAALLKsLRSRLRD molecular association, regulation; enzymatic activity, inhibited 14-3-3 beta(INDUCES) 14679215 2 4 0 +HSPA5 GRP78 Chaperone; Heat shock protein; KINASE P11021 3309 9q33.3 human K352-ac 3284874 VLEDSDLkKSDIDEI HSP70 molecular association, regulation; phosphorylation apoptosis, induced; signaling pathway regulation PERK(DISRUPTS) 20371724 1 1 3 induces phosphorylation of elf2a and activation of eIf2a-ATF4-CHOP pathway +Rela NFkB-p65 DNA-binding; Nuclear receptor co-regulator; Transcription factor Q04207 19697 19 A|19 4.34 cM mouse K122-ac 458970 NLGIQCVkKRDLEQA RHD_DNA_bind activity, induced; intracellular localization; phosphorylation cell differentiation, induced; transcription, induced; transcription, inhibited; transcription, altered; signaling pathway regulation 25672970; 26391411; 27381458 6 2 24 +PDGFRB PDGFRB EC 2.7.10.1; KINASE; Kinase, protein; Membrane protein, integral; Oncoprotein; Protein kinase, TK; Protein kinase, tyrosine (receptor) P09619 5159 5q32 human Y763-p 448850 DMKGDVKyADIESSN PK_Tyr_Ser-Thr molecular association, regulation SHP-2(INDUCES) 10391677; 11896619; 17403678 6 1 2 +HK2 HK2 Carbohydrate Metabolism - amino sugar and nucleotide sugar; Carbohydrate Metabolism - fructose and mannose; Carbohydrate Metabolism - galactose; Carbohydrate Metabolism - glycolysis and gluconeogenesis; Carbohydrate Metabolism - starch and sucrose; EC 2.7.1.1; Kinase, other; Mitochondrial P52789 3099 2p12 human Y686-p 62906106 GTGSNACyMEEMRNV Hexokinase_2 cell motility, induced 28054552 1 1 0 promote cell migration and invasion +Etv1 ETV1 DNA-binding; Oncoprotein; Transcription factor P41164 14009 12 A3|12 17.99 cM mouse T143-p 3059604 NPPTPSStPVSPLHH ETS_PEA3_N activity, induced transcription, induced; signaling pathway regulation 22586091 2 0 0 +LRP6 LRP6 Membrane protein, integral; Receptor, misc. O75581 4040 12p13.2 human S1490-p 456289 AILNPPPsPATERSH activity, induced; molecular association, regulation; phosphorylation cell cycle regulation; carcinogenesis, induced; cell growth, induced; transcription, induced; signaling pathway regulation; transcription, altered axin 1(INDUCES); caveolin-1(INDUCES) 14731402; 16341017; 16890161; 21887268; 22558232; 25500543; 25735981; 27821587; 34615853; 35277657; 35487243; 35637196 32 13 55 induces WNT signaling; Wnt signaling; induces the Wnt/?-catenin signalling pathway; induces Wnt/?-catenin signaling pathway +Arhgef7 ARHGEF7 GEF; GEF, Rac/Rho; Motility/polarity/chemotaxis Q9ES28 54126 8|8 A1.1 mouse Y755-p 1443172900 DLSEDSEyDSIWTAH activity, induced; molecular association, regulation neural plasticity; cytoskeletal reorganization GluR2(INDUCES) 30683798 1 0 0 +SUPT5H SPT5 RNA-binding; Transcription, coactivator/corepressor O00267 6829 19q13.2 human T768-p 458814 MTSTYGRtPMYGSQT transcription, altered 16427012 1 0 13 required for c-fos induction and activation in vivo +GP1BA GPIbA Cell adhesion; Cell surface; Membrane protein, integral P07359 2811 17p13.2 human S632-p 1983279 GRRPSALsQGRGQDL molecular association, regulation cytoskeletal reorganization 14-3-3 sigma(INDUCES); 14-3-3 zeta(INDUCES); PIK3R1(INDUCES) 15054037; 18299448; 19874472 3 10 19 cell spreading (not adhering efficiency) +ISL1 ISL1 Cell development/differentiation; DNA-binding; Motility/polarity/chemotaxis; Nuclear receptor co-regulator; Transcription factor P61371 3670 5q11.1 human S269-p 515814094 GTPMVAAsPERHDGG protein stabilization; molecular association, regulation; ubiquitination cell cycle regulation; carcinogenesis, induced; cell differentiation, induced; cell growth, induced; transcription, induced DNA(INDUCES) 33962568; 34329593 2 1 0 inhibits ubiquitination +Ntrk2 TrkB EC 2.7.10.1; KINASE; Kinase, protein; Membrane protein, integral; Protein kinase, TK; Protein kinase, tyrosine (receptor) P15209 18212 13 B1|13 31.2 cM mouse Y816-p 451754 LAKASPVyLDILG__ receptor internalization, induced; molecular association, regulation; intracellular localization; phosphorylation; enzymatic activity, induced neural plasticity; apoptosis, inhibited; transcription, induced; signaling pathway regulation PLCG1(INDUCES); AP2M1(INDUCES) 21543608; 27680698; 31004063; 32358047; 32427585; 34343610; 36682419 20 0 0 +Bach2 BACH2 DNA-binding; Transcription factor P97303 12014 4|4 A5 mouse S535-p 25731482 AEDGSGGsPCSLPLC protein degradation; intracellular localization; activity, inhibited transcription, induced 26620562; 28993481 2 1 2 cytoplasmic localization; increased repressor activity of Bach2 S509A and Bach2 S535A mutants was observed +NFYA NFYA DNA-binding; Transcription factor P23511 4800 6p21.1 human S326-p 3182071 FSPKEKDsPHMQDPN intracellular localization cell cycle regulation; transcription, induced 30589568 1 32 2 +FUS hnRNP P2 DNA-binding; Nuclear receptor co-regulator; Oncoprotein; RNA splicing; RNA-binding; SUMO LIGASE P35637 2521 16p11.2 human R522-me 1873375606 GEHRQDRrERPY___ intracellular localization KPNB2(DISRUPTS) 22968170 1 0 0 Arginines in the RGG3 domain are required for nuclear import of mutant hnRNP, and arginine methylation in this domain reduces KPNB2 binding. +DRD2 DRD2 GPCR, family 1; Membrane protein, integral; Membrane protein, multi-pass; Receptor, GPCR P14416 1813 11q23.2 human T225-p 13270200 RRRKRVNtKRSSRAF 7tm_1 receptor internalization, altered 20160122 2 0 0 +Aqp4 AQP4 Channel, misc.; Membrane protein, integral; Membrane protein, multi-pass; Transporter; Transporter, aquaporin family P47863 25293 18p13 rat S276-p 465556 AAQQTKGsYMEVEDN protein degradation; molecular association, regulation; intracellular localization AP3M1(INDUCES) 11742978 2 6 0 +Mapt Tau ACETYLTRANSFERASE; Acetyltransferase; Cytoskeletal P19332 29477 10q32.1 rat S667-p 449104 RVQSKIGsLDNITHV Tubulin-binding cytoskeletal reorganization 18245083 35 24 0 +Raf1 RAF1 EC 2.7.11.1; KINASE; Kinase, protein; Oncoprotein; Protein kinase, Ser/Thr (non-receptor); Protein kinase, TKL Q99N57 110157 6 E3|6 53.62 cM mouse S338-p 447742 RPRGQRDsSYYWEIE activity, induced; molecular association, regulation; phosphorylation; enzymatic activity, induced carcinogenesis, induced; cell motility, induced; cell growth, induced; apoptosis, inhibited; signaling pathway regulation RAF1(DISRUPTS); RASA1(DISRUPTS); ROCK2(INDUCES) 10205168; 15026317; 15899852; 22169110; 22388104; 23993095; 28270557; 31312020 92 2 7 +CHUK IKKA EC 2.7.11.10; KINASE; Kinase, protein; Protein kinase, Other; Protein kinase, Ser/Thr (non-receptor) O15111 1147 10q24.31 human S176-p 447778 AKDVDQGsLCTSFVG Pkinase enzymatic activity, induced transcription, induced; signaling pathway regulation 33883226; 34017102; 9520446 34 1 0 TRIM26 enhances TLRs-induced NF-kB and MAPK signaling. +DRD2 DRD2 GPCR, family 1; Membrane protein, integral; Membrane protein, multi-pass; Receptor, GPCR P14416 1813 11q23.2 human K221-ub 1877221606 IVLRRRRkRVNTKRS 7tm_1 protein degradation 32572597 1 0 0 +RBL2 Rb-like 2 Transcription, coactivator/corepressor; Tumor suppressor Q08999 5934 16q12.2 human S1068-p 449740 HKNETMLsPREKIFY molecular association, regulation cell cycle regulation E2F4(DISRUPTS) 11157749 2 13 11 +FOXO3 FOXO3A Autophagy; DNA-binding; Oncoprotein; Transcription factor O43524 2309 6q21 human S318-p 453423 SRTNSNAsTVSGRLS activity, induced; intracellular localization cell cycle regulation; transcription, inhibited SMAD4(INDUCES); SMAD3(INDUCES) 21532621; 33828192; 35077510 11 0 1 +HDAC1 HDAC1 DEACETYLASE; Deacetylase; EC 3.5.1.98; Hydrolase; Nuclear receptor co-regulator Q13547 3065 1p35.2-p35.1 human K74-ub 15389913 YHSDDYIkFLRSIRP Hist_deacetyl protein degradation 26832969 2 8 3 enhances vascular calcification +PABIR1 FAM122A Unknown function Q96E09 116224 9q21.11 human S37-p 3208890 GGLRRSNsAPLIHGL protein stabilization; molecular association, regulation; ubiquitination; intracellular localization; activity, inhibited; phosphorylation cell cycle regulation; carcinogenesis, induced; signaling pathway regulation 14-3-3 beta(INDUCES); PPP2CA(DISRUPTS) 33108758 2 35 124 induces WEE1 dephosphorylation and stabilization by inhibiting its ubiquitination, regulates the ATR-CHK1-WEE1 pathway +AKT1 Akt1 EC 2.7.11.1; KINASE; Kinase, protein; Oncoprotein; Protein kinase, AGC; Protein kinase, Ser/Thr (non-receptor) P31749 207 14q32.33 human S477-p 8086735 PQFSYSAsGTA____ molecular association, regulation; phosphorylation; enzymatic activity, induced cell cycle regulation; carcinogenesis, induced; cell growth, induced; apoptosis, inhibited Sin1(INDUCES) 24670654 2 5 2 primed for phosphorylation of S473 +Ppp2r5d PPP2R5D Motility/polarity/chemotaxis; PHOSPHATASE; Protein phosphatase, regulatory subunit Q7TNL5 21770 17 22.9 cM|17 C mouse S566-p 457390 KVLLRRKsELPQDVY enzymatic activity, induced 17301223; 20106966 7 53 347 +RAF1 RAF1 EC 2.7.11.1; KINASE; Kinase, protein; Oncoprotein; Protein kinase, Ser/Thr (non-receptor); Protein kinase, TKL P04049 5894 3p25.2 human S359-p 28070702 STRIGSGsFGTVYKG PK_Tyr_Ser-Thr enzymatic activity, inhibited 23680146 1 0 0 +Nfkbia IkB-alpha DNA-binding; Inhibitor Q9Z1E3 18035 12|12 C1 mouse K21-sm 2535907 EGPRDGLkKERLVDD protein stabilization 14613580 6 0 0 +Nr1i2 PXR DNA-binding; Nuclear receptor O54915 18171 16|16 B3 mouse S347-p 4668103 MQAISLFsPDRPGVV Hormone_recep molecular association, regulation apoptosis, inhibited; transcription, altered DNA(INDUCES) 32798464; 35609418 9 0 0 +INSR INSR EC 2.7.10.1; KINASE; Kinase, protein; Membrane protein, integral; Protein kinase, TK; Protein kinase, tyrosine (receptor) P06213 3643 19p13.2 human Y999-p 447685 YASSNPEyLSASDVF activity, induced; molecular association, regulation; receptor internalization, altered; phosphorylation; enzymatic activity, induced cell cycle regulation SOCS3(INDUCES) 10340378; 10821852; 10852715; 11325969; 1647198; 1658004; 7508445 25 0 0 IRS-1 and p52Shc phosphorylation, Ras activation; phosphorylation of pp185, activation of glycogen synthesis +RET Ret EC 2.7.10.1; KINASE; Kinase, protein; Membrane protein, integral; Oncoprotein; Protein kinase, TK; Protein kinase, tyrosine (receptor) P07949 5979 10q11.21 human S909-p 62373700 EDSYVKRsQGRIPVK PK_Tyr_Ser-Thr enzymatic activity, induced 28009299 1 0 0 Dual-speci?city kinase activity +CACNA1B CACNA1B Channel, calcium; Membrane protein, integral; Membrane protein, multi-pass Q00975 774 9q34.3 human T421-p 465546 DVLKRAAtKKSRNDL activity, inhibited 11053424 4 0 0 +POLH POLH DNA repair, damage; EC 2.7.7.7; Transferase Q9Y253 5429 6p21.1 human S687-p 4931282 QGKRNPKsPLACTNK protein stabilization; molecular association, regulation cell cycle regulation; DNA repair, altered PCNA(DISRUPTS) 26988343; 28934491 3 5 9 cell survival +Sqstm1 SQSTM1 Autophagy; Nuclear receptor co-regulator; Ubiquitin conjugating system Q64337 18412 11|11 B1.3 mouse T272-p 454787 RSRLTPTtPESSSTG cell cycle regulation; carcinogenesis, altered; transcription, induced; signaling pathway regulation 20974803; 33395605 9 80 278 Keap1-Nrf2 signaling; in Ras-transformed embryonic fibroblasts +Uhrf1 UHRF1 DNA-binding; EC 6.3.2.-; EC 6.3.2.19; Ligase; Transcription factor; UBIQUITIN LIGASE; Ubiquitin conjugating system; Ubiquitin ligase Q8VDF2 18140 17|17 D mouse S656-p 469962 STGPTLSsPRASKKS protein degradation; ubiquitination; intracellular localization cell differentiation, induced; transcription, induced 31515281 3 12 0 +SMAD1 SMAD1 DNA-binding; Transcription factor Q15797 4086 4q31.21 human S206-p 451175 SSSTYPHsPTSSDPG protein degradation; molecular association, regulation; ubiquitination; intracellular localization transcription, altered YAP1(INDUCES) 17289590; 19914168; 9335504 3 0 0 +ATP2A2 SERCA2 Cell adhesion; EC 3.6.3.8; Endoplasmic reticulum; Hydrolase; Membrane protein, integral; Membrane protein, multi-pass; Transporter; Transporter, ion channel P16615 488 12q24.11 human K460-ub 12336210 NVFDTELkGLSKIER Cation_ATPase protein degradation 35611810 1 6 13 SIGMAR1 interacts with Q615 site and mediates SERCA2 degradation +LHX3 LHX3 DNA-binding; Transcription factor Q9UBR4 8022 9q34.3 human Y227-p 455296 GRQRWGQyFRNMKRS activity, induced transcription, induced 15517599 1 0 0 no change in binding to DNA or to certain proteins (NLI, PIT1, or MRG1) +Mitf MITF iso8 DNA-binding; Oncoprotein; Transcription factor Q08874-8 17342 6 D3|6 45.05 cM mouse S173-p 467214 PGLTISNsCPANLPN molecular association, regulation; intracellular localization transcription, altered 14-3-3 zeta(INDUCES) 16822840 1 0 0 +HADHA HADHA ACETYLTRANSFERASE; Acetyltransferase; Amino Acid Metabolism - lysine degradation; Amino Acid Metabolism - tryptophan; Amino Acid Metabolism - valine, leucine and isoleucine degradation; Carbohydrate Metabolism - butanoate; Carbohydrate Metabolism - propanoate; EC 1.1.1.211; EC 4.2.1.17; Lipid Metabolism - fatty acid; Lipid Metabolism - fatty acid elongation in mitochondria; Lipid Metabolism - unsaturated fatty acid biosynthesis; Lyase; Mitochondrial; Other Amino Acids Metabolism - beta-alanine; Oxidoreductase; Secondary Metabolites Metabolism - limonene and pinene degradation P40939 3030 2p23.3 human Y271-p 1883585000 LVEKLTAyAMTIPFV intracellular localization 37424790 1 1 0 +RPL11 RPL11 Motility/polarity/chemotaxis; Nucleolus; Ribosomal; Translation P62913 6135 1p36.11 human K159-ne 12067608 GAKHRISkEEAMRWF Ribosomal_L5_C protein stabilization; intracellular localization 19713960 1 0 0 +Rangap1 RANGAP1 GAP; GAP, Ras P46061 19387 15 E1|15 38.21 cM mouse K526-sm 2251700 LIHMGLLkSEDKIKA RanGAP1_C sumoylation; intracellular localization 15931224; 9442102 11 12 0 +HDAC2 HDAC2 DEACETYLASE; Deacetylase; EC 3.5.1.98; Nuclear receptor co-regulator; Transcription, coactivator/corepressor Q92769 3066 6q21 human K51-sm 1877676805 LNYGLYRkMEIYRPH Hist_deacetyl acetylation; enzymatic activity, induced 30873037 1 0 0 inhibited IL-8 acetylation +EXOSC9 EXOSC9 EC 3.1.13.-; Nucleolus; RNA processing; Ribonuclease Q06265 5393 4q27 human S392-p 3194465 QDAPIILsDSEEEEM molecular association, regulation SUMO2(INDUCES); SUMO1(INDUCES) 19217413 1 18 1 +STK4 MST1 Autophagy; EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, STE; Protein kinase, Ser/Thr (non-receptor) Q13043 6789 20q13.12 human K35-ac 3847599 EVFDVLEkLGEGSYG Pkinase protein stabilization; molecular association, regulation carcinogenesis, inhibited HSC70(DISRUPTS) 26657153 1 0 1 +Pth1r PTHR GPCR, family 2; Membrane protein, integral; Membrane protein, multi-pass; Receptor, GPCR P25961 56813 8q32 rat S501-p 2853104 YSYGPMVsHTSVTNV receptor internalization, altered; activity, inhibited 11773434; 18577695 2 0 0 +Cacna1c CACNA1C Channel, calcium; Membrane protein, integral; Membrane protein, multi-pass Q01815 12288 6 F1|6 55.86 cM mouse S1670-p 4714250 PEIRRAIsGDLTAEE CAC1F_C phosphorylation 27103070 17 7 0 ISO-triggered dissociation of the CACNAIC prevents subsequent phosphorylation +Zbed3 ZBED3 DNA-binding Q9D0L1 72114 13|13 D1 mouse T113-p 6738703 CPPPPSPtMAAEGDW molecular association, regulation axin 1(INDUCES) 19141611 1 0 0 interaction beween ZBED3 and axin is important for ZBED3 to inhibit beta catenin (CTNNB1) phosphorylation by GSK3 beta ; activates Wnt signaling +Tbc1d17 TBC1D17 GAP; GAP, Rab Q8BYH7 233204 7|7 B3 mouse S168-p 1873559800 RALLRVLsRYLLLAS PH_RBD intracellular localization; protein conformation; activity, inhibited 34045668 1 0 0 induces GLUT5 translocation +JAK2 JAK2 EC 2.7.10.2; KINASE; Kinase, protein; Oncoprotein; Protein kinase, TK; Protein kinase, tyrosine (non-receptor) O60674 3717 9p24.1 human S518-p 56527201 VFRTNGVsDVPTSPT enzymatic activity, induced transcription, induced 27368100 1 1 0 STAT3 activity induced +BCAM Lu Membrane protein, integral; Receptor, misc. P50895 4059 19q13.32 human S621-p 455912 SGGARGGsGGFGDEC molecular association, regulation cell motility, induced; cell adhesion, induced; cell adhesion, altered Lu(INDUCES) 15975931; 31413112 2 6 0 Dimerization of Lu, induce cell migration on Lamnin 521. +RAF1 RAF1 EC 2.7.11.1; KINASE; Kinase, protein; Oncoprotein; Protein kinase, Ser/Thr (non-receptor); Protein kinase, TKL P05625 396245 chicken Y341-p 447750 GQRDSSYyWEIEASE enzymatic activity, induced apoptosis, inhibited 12843393; 12952943 35 1 1 +Cdh2 CDH2 Cell adhesion; Membrane protein, integral; Motility/polarity/chemotaxis Q9Z1Y3 83501 18p13 rat S872-p 382737702 STAGSLSsLNSSSSG CADH_Y-type_LIR intracellular localization cytoskeletal reorganization CTNNB1(INDUCES) 29133434 1 0 0 PKD1 colocalizes with N-cadherin at dendritic spines mainly in the postsynaptic compartment, long-term potentiation (LTP) induction and regulates synaptic plasticity +Bdkrb2 BKR2 GPCR, family 1; Membrane protein, integral; Membrane protein, multi-pass; Receptor, GPCR P25023 25245 6q32 rat Y352-p 452100 RKKSREVyQAICRKG activity, induced; receptor desensitization, altered 9837936 3 2 0 +PHB2 BAP37 Mitochondrial; Nuclear receptor co-regulator; Transcription, coactivator/corepressor Q99623 11331 12p13.31 human S91-p 22342307 RARPRKIsSPTGSKD Band_7 apoptosis, inhibited; transcription, induced 21689744; 24522204 2 9 1 +Ctbp1 CTBP1 Cell cycle regulation; EC 1.1.1.-; Nuclear receptor co-regulator; Oxidoreductase; Transcription, coactivator/corepressor Q9Z2F5 rat S147-p 455351 REGTRVQsVEQIREV 2-Hacid_dh; 2-Hacid_dh_C molecular association, regulation; intracellular localization neural plasticity; endocytosis, induced PLD1(INDUCES); 14-3-3 gamma(INDUCES); BSN(DISRUPTS) 22366688; 32075774 7 2 0 +MAP4 MAP4 Cytoskeletal; Motility/polarity/chemotaxis P27816 4134 3p21.31 human S928-p 468166 SRLATNTsAPDLKNV Tubulin-binding protein degradation; molecular association, regulation cell cycle regulation; cytoskeletal reorganization; signaling pathway regulation E7(DISRUPTS) 31253867 1 53 122 +NFE2L2 NRF2 DNA-binding; Transcription factor Q16236 4780 2q31.2 human T395-p 40642203 VKQNGPKtPVHSSGD intracellular localization 25909891 1 0 0 nuclear translocation +ADRA2A ADRA2A GPCR, family 1; Membrane protein, integral; Membrane protein, multi-pass; Receptor, GPCR P08913 150 10q25.2 human S314-p 456352 DLEESSSsDHAERPP 7tm_1 activity, inhibited 7876239 1 3 0 +Tubb5 TUBB Cytoskeletal; Motility/polarity/chemotaxis P99024 22154 17|17 B1 mouse S172-p 460692 NTFSVVPsPKVSDTV Tubulin molecular association, regulation TUBB(DISRUPTS) 16371510 1 27 1 inhibits tubulin polymerization in vivo and in vitro +Trpv6 TRPV6 Channel, calcium; Membrane protein, integral; Membrane protein, multi-pass Q9R186 114246 4q23 rat Y201-p 473577 YRPHNLIyYGEHPLS activity, induced 17197020 1 0 0 regulates calcium influx +Gabrg2 GABRG2 Channel, chloride; Channel, ligand-gated; Membrane protein, integral; Membrane protein, multi-pass; Transporter; Transporter, ion channel P22723 14406 11 A5|11 24.8 cM mouse K370-ub 14694705 KPSKDKDkKKKNPLL Neur_chan_memb protein degradation; receptor internalization, altered 19815531 1 0 0 regulation of the late endosomal/lysosomal trafficking of GABA receptors, regulation of synaptic transmission +Mdm2 MDM2 EC 6.3.2.-; EC 6.3.2.19; Inhibitor; Ligase; NEDDYLATION LIGASE; Neddylation Ligase; Nucleolus; Oncoprotein; UBIQUITIN LIGASE; Ubiquitin conjugating system; Ubiquitin ligase P23804 17246 10 D2|10 66.32 cM mouse S163-p 448130 SSRRRSIsETEENTD intracellular localization carcinogenesis, induced; apoptosis, inhibited 20657550; 20841468; 34298892 50 19 5 +GHR GH receptor Membrane protein, integral; Receptor, cytokine P19941 100009325 rabbit Y566-p 486257 SFNQEDIyITTESLT GHBP molecular association, regulation STAT5A(INDUCES); STAT5B(INDUCES) 17666591 3 0 0 +HNRNPK hnRNP K RNA splicing; RNA-binding; Spliceosome P61978 3190 9q21.32 human R296-m1 8092821 PPPPPPGrGGRGGSR molecular association, regulation; phosphorylation apoptosis, inhibited PKCD(DISRUPTS) 25104022 1 3 19 methylation of R296 and R299 suppress S302 phosphorylation, R296/R299 methylation reduces apoptosis in U2OS-K- 2RK cells after DNA damage +CERT1 COL4A3BP EC 2.7.11.9; KINASE; Kinase, protein; Lipid-binding; Protein kinase, Ser/Thr (non-receptor); Protein kinase, atypical Q9Y5P4 10087 5q13.3 human T148-p 4777484 SGYSATStSSFKKGH molecular association, regulation; activity, inhibited 28652409 0 2 0 reduced PtdIns(4)P binding affinity as well as low ceramide transfer activity, E494R/N495K/P535R/E537K mutations, recovery of both PtdIns(4)P binding and ceramide transfer activity. +Tbx2 TBX2 DNA-binding; Transcription factor Q60707 21385 11 C|11 51.34 cM mouse S336-p 1308918 PAREPPPsPSAAPSP TBX activity, induced; protein stabilization; intracellular localization transcription, inhibited 18025091 1 3 0 relocalizes into nuclei after UV radiation +TP53 p53 Activator; DNA-binding; Motility/polarity/chemotaxis; Nuclear receptor co-regulator; Transcription factor; Tumor suppressor P04637 7157 17p13.1 human K305-ac 458979 ELPPGSTkRALPNNT intracellular localization; phosphorylation transcription, induced 12724314; 19339993; 21297583; 31680191 7 3 13 20, 164, 305, 320, 370/372/373, 381/382/386 K-R mutants diminsished transactivation, and selective regulation of target genes expression through distinct mechanisms +CCNH CCNH Cell cycle regulation P51946 902 5q14.3 human S304-p 12521707 YEDDDYVsKKSKHEE transcription, altered; cell growth, altered 10993082 1 0 1 +Vav3 VAV3 Actin-binding; Adaptor/scaffold; GEF; GEF, Rac/Rho; Motility/polarity/chemotaxis; Nuclear receptor co-regulator Q9R0C8 57257 3|3 F3 mouse Y173-p 455605 EDEGGEVyEDLMKAE activity, induced 35650206 6 0 0 +Srebf1 SREBP-1 DNA-binding; Membrane protein, integral; Membrane protein, multi-pass; Transcription factor P56720 78968 10q22 rat S332-p 458357 IEKRYRSsINDKIVE HLH transcription, inhibited 24853806 4 1 0 +ERCC3 XPB DNA repair, damage; EC 3.6.4.12; Helicase; Transcription factor P19447 2071 2q14.3 human S90-p 1867858202 HIFLEAFsPVYKYAQ Helicase_C_3 protein degradation; ubiquitination 30762924 1 0 0 polyubiquitination by SCF E3 ligase +Ptprr PTP-SL iso2 EC 3.1.3.48; Membrane protein, integral; Motility/polarity/chemotaxis; PHOSPHATASE; Receptor protein phosphatase, tyrosine Q62132-2 19279 10|10 D2 mouse T253-p 450119 EPFVAVStPREKVAM molecular association, regulation 9857190 2 0 1 +Atp2a2 SERCA2 Cell adhesion; EC 3.6.3.8; Endoplasmic reticulum; Hydrolase; Membrane protein, integral; Membrane protein, multi-pass; Transporter; Transporter, ion channel O55143 11938 5 62.38 cM|5 F mouse S663-p 452253 EFDELSPsAQRDACL enzymatic activity, inhibited cell growth, inhibited 37291092 1 69 3 ,regulates Ca2+ homeostasis +Marcks MARCKS Actin-binding; Motility/polarity/chemotaxis P26645 17118 10 B1|10 19.49 cM mouse S46-p 454165 VKVNGDAsPAAAEPG MARCKS protein conformation 31980612 3 41 0 +Ksr1 KSR KINASE; Kinase, protein; Protein kinase, Ser/Thr (non-receptor); Protein kinase, TKL Q61097 16706 11 B5|11 46.74 cM mouse T549-p 4956353 ISRKASQtSVYLQEW phosphorylation 23993095 1 0 2 induces phosphorylation of ERK +NGEF ephexin-1 GEF; GEF, Rac/Rho Q8N5V2 25791 2q37.1 human S18-p 34499273 KTRRKSAsDQWNTDN molecular association, regulation; phosphorylation carcinogenesis, induced; cell growth, induced; signaling pathway regulation KRas(INDUCES) 34711817 1 2 0 induces C-Raf phosphorylation, induces Ras/MAPK signaling pathway +Gria2 GluR2 Channel, calcium; Channel, ligand-gated; Membrane protein, integral; Membrane protein, multi-pass P19491 29627 2q33 rat K882-ub 7253603 VYGIESVkI______ protein degradation; intracellular localization 25660027 2 0 1 +NOX5 NOX5 EC 1.6.3.-; Membrane protein, integral; Membrane protein, multi-pass; Oxidoreductase Q96PH1 79400 15q23 human Y478-p 1869973808 YRPGDYLyLNIPTIA FAD_binding_8 signaling pathway regulation 32792487 1 0 0 activation of Src, Pyk2-mediated phosphorylation of Nox5 +ARFIP1 arfaptin 1 iso2 G protein regulator, misc. P53367-2 27236 4q31.3 human S100-p 3191827 LELVRKWsLNTYKCT Arfaptin molecular association, regulation; intracellular localization arfaptin 2(DISRUPTS) 23695357 3 32 43 dissociation from trans-Golgi network; inhibits intracellular localization of TGN +Map3k3 MEKK3 EC 2.7.11.25; KINASE; Kinase, protein; Protein kinase, STE; Protein kinase, Ser/Thr (non-receptor) Q61084 26406 11|11 E1 mouse S166-p 3188100 EPRSRHLsVSSQNPG enzymatic activity, inhibited 12761204 2 32 42 +MAVS MAVS Adaptor/scaffold; Membrane protein, integral Q7Z434 57506 20p13 human K461-ub 14991109 GPEENEYkSEGTFGI protein degradation; molecular association, regulation MAVS(INDUCES) 20483786; 27992402; 31270229 3 0 0 +F11R JAM-A Cell adhesion; Membrane protein, integral Q9Y624 50848 1q23.3 human Y280-p 458767 TSSKKVIySQPSARS molecular association, regulation cell motility, induced CSK(INDUCES) 24300854; 35293964 3 27 902 +HTT Huntingtin Cytoskeletal P42858 3064 4p16.3 human S2114-p 1870026105 QCWTRSDsALLEGAE activity, induced; molecular association, regulation; protein conformation PRRC2C(DISRUPTS) 32668197 1 1 0 +USP8 USP8 DEUBIQUITINASE; EC 3.4.19.12; Protease; Ubiquitin conjugating system; Ubiquitin-specific protease P40818 9101 15q21.2 human Y810-p 23071951 DYFNRNCyQDDINRS UCH cell cycle regulation 29472535 1 1 2 trichoplein-mediated inhibition of ciliogenesis +AKT3 Akt3 EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, AGC; Protein kinase, Ser/Thr (non-receptor) Q9Y243 10000 1q43-q44 human T305-p 448521 TDAATMKtFCGTPEY Pkinase phosphorylation carcinogenesis, induced; cell growth, induced 36476861 9 5 11 induces TSC2 phosphorylation +ITPKB ITPKB Carbohydrate Metabolism - inositol phosphate; EC 2.7.1.127; Kinase, lipid; Motility/polarity/chemotaxis P27987 3707 1q42.12 human S174-p 3189511 PRLGRARsPSPCPFR molecular association, regulation; enzymatic activity, induced carcinogenesis, induced Calmodulin(INDUCES) 35039634 1 26 8 +FYN Fyn EC 2.7.10.2; KINASE; Kinase, protein; Oncoprotein; Protein kinase, TK; Protein kinase, tyrosine (non-receptor) P06241 2534 6q21 human Y214-p 455043 KLDNGGYyITTRAQF SH2 activity, induced; molecular association, regulation; protein conformation; enzymatic activity, induced 17389760; 27001024 2 22 656 autophosphorylation reduces its ability to bind to ESDN/DCBLD2; hyper-active conformation of Fyn ; reduces SH2-dependent binding interactions +Git1 GIT1 GAP; GAP, ARF; Motility/polarity/chemotaxis Q9Z272 83709 10q24 rat Y554-p 448965 ELEDDAIySVHVPAG molecular association, regulation cell motility, induced eNOS(INDUCES); PXN(DISRUPTS); Hic-5(DISRUPTS) 24764294; 25742295 4 39 737 phosphorylation-dephosphorylation required for coordinated cell movement, Y545-p was essential for Git1-mediated protrusion activity. +SATB1 SATB1 DNA-binding; Transcription factor Q01826 6304 3p24.3 human T188-p 13906400 PEQWSHTtVRNALKD CUTL sumoylation; molecular association, regulation; intracellular localization PIAS1(DISRUPTS) 20351170 1 0 0 +TTK TTK Cancer Testis Antigen (CTA); EC 2.7.12.1; KINASE; Kinase, protein; Protein kinase, Other; Protein kinase, dual-specificity (non-receptor) P33981 7272 6q14.1 human T676-p 487540 NQMQPDTtSVVKDSQ Pkinase activity, induced; molecular association, regulation; intracellular localization; enzymatic activity, induced cell cycle regulation; carcinogenesis, inhibited; chromatin organization, altered; cytoskeletal reorganization TTK(NOT_REPORTED) 17728254; 18083840; 18545697; 18680479; 26119734; 31511308; 34775484 15 5 0 +CTNNA2 CTNNA2 Cancer Testis Antigen (CTA); Cytoskeletal; Motility/polarity/chemotaxis P26232 1496 2p12 human K696-ub 52485009 IFHQEKSkLDAEVAK Vinculin protein degradation 26676607 0 1 0 +PIP5K1C PIP5K1C Carbohydrate Metabolism - inositol phosphate; EC 2.7.1.68; Kinase, lipid; Motility/polarity/chemotaxis O60331 23396 19p13.3 human S650-p 457599 DERSWVYsPLHYSAQ molecular association, regulation; intracellular localization; phosphorylation cytoskeletal reorganization; cell adhesion, altered talin 1(DISRUPTS) 15738269 2 1 0 inhibits phosphorylation at PIP5KG at Y649 +NR3C2 MCR DNA-binding; Nuclear receptor P08235 4306 4q31.23 human K428-sm 3287300 SSFSVPIkQESTKHS transcription, inhibited 14500761 2 3 0 +Sod2 SOD2 EC 1.15.1.1; Mitochondrial; Oxidoreductase P09671 20656 17 A1|17 8.75 cM mouse K89-ac 33350066 VALQPALkFNGGGHI Sod_Fe_N protein conformation; enzymatic activity, altered 28433661 0 3 0 +SOX8 SOX8 DNA-binding P57073 30812 16p13.3 human S327-p 4715062 SAPSASAsPTETGPP intracellular localization carcinogenesis, induced; apoptosis, inhibited; transcription, altered; signaling pathway regulation 32550913 1 2 0 AurA/SOXB/FOXK1 signaling pathway +DUSP12 DUSP12 EC 3.1.3.16; EC 3.1.3.48; Motility/polarity/chemotaxis; PHOSPHATASE; Protein phosphatase, dual-specificity Q9UNI6 11266 1q23.3 human Y179-p 1880475700 VDTSSAIyKQYRLQK intracellular localization 36370849 1 1 0 +Flt3 FLT3 EC 2.7.10.1; KINASE; Kinase, protein; Membrane protein, integral; Oncoprotein; Protein kinase, TK; Protein kinase, tyrosine (receptor) Q00342 14255 5 86.88 cM|5 G3 mouse Y845-p 454872 DILSDSSyVVRGNAR PK_Tyr_Ser-Thr protein stabilization; enzymatic activity, induced 16091740 5 2 76 +VCP VCP Chaperone; DNA repair, damage; EC 3.6.4.6; Endoplasmic reticulum; Hydrolase P55072 7415 9p13.3 human S746-p 457557 AMRFARRsVSDNDIR Vps4_C apoptosis, inhibited 16551632 2 5 1 +GAPDH GAPDH Carbohydrate Metabolism - glycolysis and gluconeogenesis; EC 1.2.1.12; Oxidoreductase P04406 2597 12p13.31 human R248-m2 1878232000 SVVDLTCrLEKPAKY enzymatic activity, induced GAPDH(INDUCES) 31324208 1 1 0 enhances GAPDH activity by promoting the assembly of an active tetramer, promotes glycolysis and mitochondrial respiration, PRMT3 increases the sensitivity of pancreatic cancer cells to GAPDH blockage +CDT1 CDT1 DNA replication; DNA-binding; Motility/polarity/chemotaxis; Oncoprotein Q9H211 81620 16q24.3 human S411-p 21440504 PATPPAAsPSALKGV protein stabilization; molecular association, regulation; activity, inhibited; phosphorylation RAMP(DISRUPTS); MCM2(DISRUPTS) 21930785; 32841231 2 0 1 inhibits Chk1 phosphorylation +Prkcb PKCB iso2 EC 2.7.11.13; KINASE; Kinase, protein; Motility/polarity/chemotaxis; Protein kinase, AGC; Protein kinase, Ser/Thr (non-receptor) P68404-2 18751 7 F2|7 65.75 cM mouse T641-p 1869073010 TRHPPVLtPPDQEVI Pkinase_C molecular association, regulation; protein conformation; phosphorylation; enzymatic activity, induced PKCB iso2(DISRUPTS) 33850054 9 41 44 induces phosphorylation at S660 +NFATC1 NFAT2 DNA-binding; Transcription factor O95644 4772 18q23 human S153-p 1869090803 PSSKRSPsTATLSLP activity, induced carcinogenesis, induced; cell motility, induced; transcription, induced 31730483 1 1 0 multiple sites mutatnt +SGK1 SGK1 EC 2.7.11.1; KINASE; Kinase, protein; Motility/polarity/chemotaxis; Protein kinase, AGC; Protein kinase, Ser/Thr (non-receptor) O00141 6446 6q23.2 human T256-p 448431 EHNSTTStFCGTPEY Pkinase molecular association, regulation; phosphorylation; enzymatic activity, induced apoptosis, inhibited; transcription, induced; signaling pathway regulation 10191262; 11096081; 11956329; 18456663; 22042038; 25384981; 33890983 15 0 0 induces phosphorylation of NEDD4L and CFTR; regulates aldosterone-stimulated SGK1-NFkB pathway for glomerular fibrosis and inflammation; HSP90 is required for SGK kinase activity.; IkB phosphorylation increased; phosphorylates Tau at S214; adhesion dependent activation +Etv4 ETV4 DNA-binding P28322 18612 11 D|11 65.48 cM mouse K112-ac 26373302 PALSCSRkPPLPYHH ETS_PEA3_N sumoylation transcription, induced 21543453 1 1 0 acetylated sites inhibits sumoylation reciprocally +Lin28a LIN28A Nucleolus; RNA-binding; Translation Q8K3Y3 83557 4|4 D3 mouse S200-p 7231811 EEEEEIHsPALLPEA activity, inhibited cell growth, inhibited; cell differentiation, induced 28179426 1 5 0 increase in let7a and let7g miRNA and decrease in cyclin D1 levels +SH3PXD2B SH3PXD2B Lipid-binding A1X283 285590 5q35.1 human Y508-p 17303901 DMSASAGyEEISDPD molecular association, regulation carcinogenesis, altered; cytoskeletal reorganization NOXA1(INDUCES) 20943948 1 0 0 +WNK4 WNK4 EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, Other; Protein kinase, Ser/Thr (non-receptor) Q96J92 65266 17q21.2 human Y1113-p 40407606 PSPVWMNySYSSLCL activity, inhibited 25805816 1 1 0 WNK4 inhibition of ROMK channels +TTK TTK Cancer Testis Antigen (CTA); EC 2.7.12.1; KINASE; Kinase, protein; Protein kinase, Other; Protein kinase, dual-specificity (non-receptor) P33981 7272 6q14.1 human S281-p 1737603 VPVNLLNsPDCDVKT protein stabilization; ubiquitination; intracellular localization cell cycle regulation; carcinogenesis, induced; cytoskeletal reorganization; signaling pathway regulation CDC27(DISRUPTS) 22430208; 30674582 2 29 1 accumulation at centrosomes, aneuploidy, correlated with p-ERK, in human metastatic melanoma; MAD1 checkpoint signaling; centrosome reduplication +Stat5a STAT5A DNA-binding; Motility/polarity/chemotaxis; Oncoprotein; Transcription factor P42230 20850 11 D|11 63.77 cM mouse S779-p 448750 DSLDARLsPPAGLFT activity, induced; molecular association, regulation; intracellular localization carcinogenesis, altered; cell growth, induced; transcription, induced HER4(INDUCES) 12732616; 15863494; 20508164; 24263804 12 25 0 +PDPK1 PDK1 EC 2.7.11.1; KINASE; Kinase, protein; Nuclear receptor co-regulator; Protein kinase, AGC; Protein kinase, Ser/Thr (non-receptor) O15530 5170 16p13.3 human T354-p 25256100 WENLHQQtPPKLTAY molecular association, regulation; enzymatic activity, inhibited apoptosis, altered; cell growth, inhibited; signaling pathway regulation 14-3-3 beta(INDUCES); STRAP(DISRUPTS) 22544756 2 0 0 alleviates PDK1-mediated supression of apoptosis +IGF1R IGF1R EC 2.7.10.1; KINASE; Kinase, protein; Membrane protein, integral; Protein kinase, TK; Protein kinase, tyrosine (receptor) P08069 3480 15q26.3 human S1278-p 4271095 EPGFREVsFYYSEEN protein stabilization; molecular association, regulation; phosphorylation signaling pathway regulation ARRB1(INDUCES) 22509025 1 0 1 S1278 induces transient association, while S1321 induces more stable association; Akt phosphorylation, regulates ERK/Akt signaling pathway +Nhej1 NHEJ1 DNA repair, damage Q3KNJ2 75570 1|1 C4 mouse S245-p 4084901 TQASSSTsPRGTDNQ activity, induced; molecular association, regulation RFC4(INDUCES); RFC1(INDUCES) 31123184 2 5 0 induce replication fork stability +MC1R MC1R GPCR, family 1; Membrane protein, integral; Membrane protein, multi-pass; Receptor, GPCR Q01726 4157 16q24.3 human T308-p 471419 HSQELRRtLKEVLTC receptor internalization, altered 17130136 1 0 0 T308 and S316 phosphorylation regulate MC1R internalization and desensitization. +Kcna1 Kv1.1 Channel, potassium; Membrane protein, integral; Membrane protein, multi-pass P10499 24520 4q42 rat S446-p 451079 SDLSRRSsSTISKSE activity, induced 9497384 2 0 0 Reduces the extent of inactivation of the channel +SOX9 SOX9 DNA-binding; Transcription factor P48436 6662 17q24.3 human S211-p 450957 FKALQADsPHSSSGM protein stabilization transcription, induced 27929080 2 1 0 PAPSS2 mRNA expression +STK38 NDR1 EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, AGC; Protein kinase, Ser/Thr (non-receptor) Q15208 11329 6p21.31 human T183-p 41425402 TLLMKKDtLTEEETQ Pkinase molecular association, regulation; intracellular localization; enzymatic activity, inhibited; protein conformation cell cycle regulation; cytoskeletal reorganization MOB1A(DISRUPTS); HCCA2(INDUCES) 26057687 1 0 0 regulation of spindle orientation, cortical localization of LGN-NuMA +PPP2CA PPP2CA EC 3.1.3.16; Motility/polarity/chemotaxis; PHOSPHATASE; Protein phosphatase, Ser/Thr (non-receptor) P67775 5515 5q31.1 human T304-p 450083 EPHVTRRtPDYFL__ molecular association, regulation; methylation; enzymatic activity, inhibited; enzymatic activity, induced cell cycle regulation; cytoskeletal reorganization; cell growth, altered PPP2R2B(DISRUPTS); PPP2R5A(DISRUPTS); PPP2R2C(DISRUPTS); PPP2R3B(INDUCES); PPP2R5D(INDUCES); PPP2R5C(DISRUPTS); PPP2R2A(NOT_REPORTED); PPP2R3A(INDUCES) 10978272; 17394530; 17635907; 32900880; 37437018 7 11 2 +DRD1 DRD1 GPCR, family 1; Membrane protein, integral; Membrane protein, multi-pass; Receptor, GPCR P21728 1812 5q35.2 human S254-p 1869357202 NGKPVECsQPESSFK 7tm_1 molecular association, regulation ARR3(INDUCES) 32503917 1 0 0 +Hnrnpm hnRNP M Nucleolus; RNA splicing; RNA-binding; Receptor, misc.; Spliceosome Q9D0E1 76936 17|17 B1 mouse S574-p 3191716 LERMGANsLERMGLE molecular association, regulation RNA splicing, induced DNA(DISRUPTS) 31693898 1 42 4 inhibits binding at the IL-6 locus +STAT1 STAT1 DNA-binding; Transcription factor P42224 6772 2q32.2 human K525-m1 1873284300 QLNMLGEkLLGPNAS activity, induced; molecular association, regulation; phosphorylation transcription, induced DNA(INDUCES) 28753426 1 1 0 induces interferon antiviral activity +Prkcd PKCD EC 2.7.11.13; KINASE; Kinase, protein; Nuclear receptor co-regulator; Protein kinase, AGC; Protein kinase, Ser/Thr (non-receptor); Protein kinase, tyrosine (non-receptor); Tumor suppressor P28867 18753 14 B|14 18.82 cM mouse Y565-p 447576 IRVDTPHyPRWITKE Pkinase enzymatic activity, inhibited carcinogenesis, inhibited 11812791 5 0 0 +IRF1 IRF1 Transcription factor; Tumor suppressor P10914 3659 5q31.1 human K50-ub 31914111 KHGWDINkDACLFRS IRF protein degradation; molecular association, regulation DNA(DISRUPTS) 23134341 1 2 0 +POLH POLH DNA repair, damage; EC 2.7.7.7; Transferase Q9Y253 5429 6p21.1 human K462-sm 1877365905 PVTSSEAkTQGSGPA intracellular localization; enzymatic activity, inhibited 32350109 1 1 0 +SLC12A3 NCCT Membrane protein, integral; Membrane protein, multi-pass; Transporter; Transporter, SLC family P55017 6559 16q13 human K828-ub 27200754 IFQSEQGkKTIDIYW SLC12 protein degradation; ubiquitination; activity, inhibited; phosphorylation endocytosis, induced 29021560 1 2 0 NCC transport activity decreased. phosphorylation inhibited +ETAA1 ETAA16 Cell surface Q9NY74 54465 2p14 human S111-p 1869465806 DIFWDQNsPLTKQLG ETAA1 cell cycle regulation; signaling pathway regulation 31615875 1 0 0 critical for chromosome stability +SH3BP2 SH3BP2 Adaptor/scaffold P78314 6452 4p16.3 human S278-p 455470 PATPRRMsDPPLSTM molecular association, regulation 14-3-3 theta(INDUCES) 12501243 1 11 1 +CTNNB1 CTNNB1 Actin-binding; Cell adhesion; Motility/polarity/chemotaxis; Nuclear receptor co-regulator; Oncoprotein; Transcription factor P35222 1499 3p22.1 human S646-p 41656202 PLTELLHsRNEGVAT intracellular localization 26187068 1 0 0 +RPS6KB1 p70S6K iso2 EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, AGC; Protein kinase, Ser/Thr (non-receptor); Translation P23443-2 6198 17q23.1 human T229-p 448606 HDGTVTHtFCGTIEY Pkinase enzymatic activity, induced 18326039 36 2 17 +ABCA4 ABCA4 Membrane protein, integral; Membrane protein, multi-pass; Transporter; Transporter, ABC family P78363 24 1p22.1 human T1313-p 20940700 PREKAGQtPQDSNVC enzymatic activity, induced 21721517 1 1 0 +Asic3 ASIC3 Channel, cation; Membrane protein, integral; Membrane protein, multi-pass; Transporter; Transporter, ion channel O35240 286920 4q11 rat T40-p 12518704 IFGPGGLtLRRGLWA TM; ASC activity, induced 14976185 1 0 0 channel activation +Nr1h3 LXR-alpha DNA-binding; Motility/polarity/chemotaxis; Nuclear receptor Q9Z0Y9 22259 2 E1|2 50.52 cM mouse S196-p 469114 SVSPRVSsPPQVLPQ molecular association, regulation; activity, inhibited chromatin organization, altered; cell growth, inhibited; transcription, altered; transcription, inhibited; signaling pathway regulation SRC-1(DISRUPTS); N-CoR1(INDUCES); RXRA(DISRUPTS) DNA(DISRUPTS) 17296605; 29950315; 30673619 6 0 0 +TARDBP TDP-43 RNA-binding Q13148 23435 1p36.22 human K145-ac 38520208 DLKTGHSkGFGFVRF RRM_1 molecular association, regulation; phosphorylation transcription, inhibited RNA(DISRUPTS) 25556531; 32409664 2 1 0 enhances TDP-43 phosphorylation, enhances accumulation of TDP-43 aggregates; TDP-43-induced cell toxicity +Cacng2 Stargazin Channel, calcium; Membrane protein, integral; Membrane protein, multi-pass O88602 12300 15 E1|15 36.92 cM mouse S249-p 455320 RSTEPSHsRDASPVG activity, induced; intracellular localization 15664178; 20670832 3 1 1 AMPAR immobilization in synaptic membrane; enhances AMPA receptor responses and is required for long-term potentiation +Vamp2 VAMP2 Membrane protein, integral; Motility/polarity/chemotaxis; Vesicle P63045 24803 10q24 rat S75-p 481819 DALQAGAsQFETSAA Synaptobrevin exocytosis, altered; endocytosis, altered 33582301 1 14 39 +Erg ERG DNA-binding; Oncoprotein; Transcription factor P81270 13876 16 C4|16 56.04 cM mouse S103-p 4712353 KGGKMVGsPDTVGMS methylation carcinogenesis, induced; cell motility, induced; cell growth, induced; transcription, induced 34314419 4 5 0 inhibits H3 methylation +NEDD8 NEDD8 Ubiquitin-like modifier Q15843 4738 14q12 human K22-ac 36299402 IDIEPTDkVERIKER ubiquitin molecular association, regulation PARP1(INDUCES) 30804002 1 2 0 +Notch1 Notch 1 Membrane protein, integral; Motility/polarity/chemotaxis; Oncoprotein; Receptor, misc.; Transcription factor Q01705 18128 2 A3|2 18.91 cM mouse K1935-ac 18899511 YSRSDAAkRLLEASA Ank_2 protein stabilization; ubiquitination 21499261 1 1 0 +NR1I2 PXR DNA-binding; Nuclear receptor O75469 8856 3q13.33 human T135-p 30259804 KKSERTGtQPLGVQG molecular association, regulation RXRA(DISRUPTS) DNA(DISRUPTS) 24184507; 32205367 2 2 0 +PSRC1 PSRC1 Q6PGN9 84722 1p13.3 human S65-p 12667967 APQGVRLsLGPLSPE GTSE1_N cytoskeletal reorganization 21473853 1 11 0 +KCNA3 Kv1.3 Channel, potassium; Membrane protein, integral; Membrane protein, multi-pass P22001 3738 1p13.3 human Y529-p 52427503 STLSKSEyMVIEEGG cell growth, induced 26655221 1 0 0 +Ppif PPIF Cyclophilin; EC 5.2.1.8; Isomerase; Mitochondrial Q99KR7 105675 14|14 A3 mouse S42-p 1241945800 ARGANSSsGNPLVYL molecular association, regulation ATP5A1(INDUCES) 30165576 1 1 0 S42D increased interaction and cell death compared to S42A mutant +EGFR EGFR EC 2.7.10.1; KINASE; Kinase, protein; Membrane protein, integral; Oncoprotein; Protein kinase, TK; Protein kinase, tyrosine (receptor) P00533 1956 7p11.2 human Y1110-p 448058 GSVQNPVyHNQPLNP molecular association, regulation; ubiquitination; receptor internalization, altered; intracellular localization; protein conformation; phosphorylation; enzymatic activity, induced DNA repair, induced; carcinogenesis, induced; cell motility, induced; transcription, altered; signaling pathway regulation RASA1(INDUCES); GRB2(INDUCES); Src(INDUCES); DOK2(INDUCES); DOK1(INDUCES); SHC1(INDUCES); STAT3(INDUCES); CBL(INDUCES) DNA(INDUCES) 10069801; 10508618; 12631709; 12873986; 1314835; 15476828; 16729043; 23644655; 24430869; 26290602; 29989005; 34367939; 35000271; 7741752; 8408058 45 38 457 EGFR autophosphorylation sites modulate STAT activation. +Kdm1a LSD1 DEMETHYLASE; Demethylase; EC 1.-.-.-; Nuclear receptor co-regulator; Oxidoreductase; Transcription factor Q6ZQ88 99982 4 D3|4 68.8 cM mouse S112-p 3828907 TPEGRRTsRRKRAKV molecular association, regulation; intracellular localization; enzymatic activity, induced transcription, induced; transcription, inhibited DNA(INDUCES) 24582500; 34078525 4 1 10 +EXO5 DEM1 EC 3.1.11.- Q9H790 64789 1p34.2 human Y221-p 1874115105 DCFQVSLyKYIFDAM molecular association, regulation; enzymatic activity, induced DNA repair, induced DNA(INDUCES) 34197737 1 0 0 +NFE2L2 NRF2 DNA-binding; Transcription factor Q16236 4780 2q31.2 human S347-p 18258501 NDSDSGIsLNTSPSV protein degradation; molecular association, regulation; ubiquitination transcription, inhibited BTRC(INDUCES) 22751928; 32295843 4 1 0 +YAP1 YAP1 Oncoprotein; Transcription, coactivator/corepressor P46937 10413 11q22.1 human S128-p 485035 QHVRAHSsPASLQLG activity, induced; molecular association, regulation; intracellular localization cell cycle regulation; cell differentiation, induced; cell motility, induced; cell growth, induced; apoptosis, inhibited; transcription, induced; transcription, inhibited TEAD1(INDUCES); TEAD4(DISRUPTS); 14-3-3 beta(DISRUPTS) 24812269; 27979971; 27979972; 28416665; 36640330; 37100374 8 12 77 +Panx1 PANX1 Cell adhesion; Membrane protein, integral; Membrane protein, multi-pass P60570 315435 8q12 rat S328-p 1871464503 SEGYNDLsLYNLFLE activity, inhibited 33276429 1 0 0 inhibits mechanical stretch induced activation of Panx1 channels +HTT Huntingtin Cytoskeletal P42858 3064 4p16.3 human K6-ac 10206806 __MATLEkLMKAFES protein stabilization; protein conformation 28334491 2 1 0 reverses inhibitory effect of T3 phosphorylation on aggregation +MLXIPL ChREBP Transcription factor Q9NP71 51085 7q11.23 human S196-p 451393 KKRLRKPsREDDLLA molecular association, regulation; intracellular localization 14-3-3 beta(INDUCES); KPNA2(DISRUPTS) 23918932 5 8 1 regulates lipogenesis +Raet1e RAET1E Membrane protein, integral Q9CZQ6 379043 10|10 A3 mouse K87-ac 1877559400 KMANATGkCLTQPLN MHC_I_2 protein stabilization 33279621 1 0 0 protects RAET1E from shedding; induces antitumor immunity +ROCK1 ROCK1 EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, AGC; Protein kinase, Ser/Thr (non-receptor) Q13464 6093 18q11.1 human T1024-p 20609219 IDRKKANtQDLRKKE intracellular localization cytoskeletal reorganization 21685893 1 1 0 inhibits apical constriction +EGFR EGFR EC 2.7.10.1; KINASE; Kinase, protein; Membrane protein, integral; Oncoprotein; Protein kinase, TK; Protein kinase, tyrosine (receptor) P00533 1956 7p11.2 human S1042-p 3178887 LSSLSATsNNSTVAC receptor internalization, induced; protein degradation 24797263 2 9 2 +Lrp1 LRP1 Cell surface; Membrane protein, integral; Motility/polarity/chemotaxis; Receptor, misc. Q91ZX7 16971 10|10 D3 mouse Y4508-p 451245 TNFTNPVyATLYMGG activity, induced; receptor internalization, induced; molecular association, regulation cell cycle regulation; signaling pathway regulation CSK(INDUCES); RAB8A(INDUCES) 20724593; 30208326 6 1 0 regulates Akt/mTOR in inflammation +Bsn BSN Cytoskeletal O88737 12217 9 F1|9 59.07 cM mouse S2860-p 456576 KTLQRSLsDPKPLSP molecular association, regulation neural plasticity 14-3-3 eta(INDUCES) 23516560 2 18 1 +CDKN1A p21Cip1 Cell cycle regulation; Inhibitor P38936 1026 6p21.2 human T145-p 447837 QGRKRRQtSMTDFYH protein degradation; protein stabilization; molecular association, regulation; intracellular localization; phosphorylation cell cycle regulation; carcinogenesis, induced; cell motility, induced; cell growth, induced; cell growth, inhibited CDK4(DISRUPTS); Akt2(DISRUPTS); CDK2(DISRUPTS); PCNA(DISRUPTS) 11231573; 11463845; 11756412; 15001356; 15173090; 16982699; 17855660; 20307683; 21159648; 26436589; 34069970 20 0 0 +RIOK1 RIOK1 EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, Ser/Thr (non-receptor); Protein kinase, atypical Q9BRS2 83732 6p24.3 human K411-m1 877067500 EIASQRTkEERSSQD protein degradation; ubiquitination cell growth, inhibited 29384474 1 1 0 RIOK1 methylation reduces the tumor growth and metastasis in mice model +Dab1 DAB1 iso2 Adaptor/scaffold P97318-2 13131 4 C6|4 47.79 cM mouse S515-p 479423 IFEEGFEsPSKSEEQ phosphorylation 16529723 1 0 0 inhibits tyrosine phosphorylation +POLI POLI DNA repair, damage; EC 2.7.7.7; Transferase Q9UNA4 11201 18q21.2 human K547-ub 22249753 QEEILSGkSREKFQG protein degradation 26370087 1 4 0 +H3C1 H3 DNA-binding P68431 8350 6p22.2 human K23-ac 458999 PRKQLATkAARKSAP Histone molecular association, regulation cell cycle regulation; DNA repair, induced; apoptosis, induced; chromatin organization, altered; transcription, induced; transcription, inhibited TIF1G(INDUCES) DNA(DISRUPTS) 20720004; 21726812; 23653357; 35222362; 36060800 32 28 422 +TRPV1 TRPV1 Channel, cation; Membrane protein, integral; Membrane protein, multi-pass; Receptor, misc. Q8NER1 7442 17p13.2 human S502-p 450016 YFLQRRPsMKTLFVD Ion_trans receptor desensitization, altered; intracellular localization 18701070; 31563651 19 0 0 +SMAD7 SMAD7 DNA-binding; Transcription factor O15105 4092 18q21.1 human K70-m1 59102100 GKAVRGAkGHHHPHP protein degradation; acetylation; ubiquitination transcription, inhibited; signaling pathway regulation RNF111(INDUCES) 27292644 1 1 0 TGF-beta signaling- regulates TGF-beta mediated activation of extracellular matrix genes, prevents acetylation, induces lung fibrosis +Rps6 S6 Translation P62754 20104 4|4 C4 mouse S240-p 448094 RLSSLRAsTSKSESS carcinogenesis, induced; carcinogenesis, inhibited 23361300; 33826903 111 69 847 +SREBF1 SREBP-1 DNA-binding; Membrane protein, integral; Membrane protein, multi-pass; Transcription factor P36956 6720 17p11.2 human S63-p 23940711 AGGTDPAsPDTSSPG transcription, induced 22384276 2 1 0 +PIK3CD PIK3CD Carbohydrate Metabolism - inositol phosphate; EC 2.7.1.153; KINASE; Kinase, lipid; Motility/polarity/chemotaxis O00329 5293 1p36.22 human S1039-p 466429 NWLAHNVsKDNRQ__ enzymatic activity, inhibited carcinogenesis, induced; cell growth, induced; apoptosis, inhibited 10064595; 24213578 2 9 0 +Shank3 SHANK3 Adaptor/scaffold Q9JLU4 59312 7q34 rat S781-p 471376 KGIPRTKsVGEDEKL neural plasticity 33568460 1 10 0 +AKAP12 AKAP12 Adaptor/scaffold Q02952 9590 6q25.1 human S627-p 476343 KKRVRRPsESDKEDE WSK receptor desensitization, inhibited; molecular association, regulation ADRB2(INDUCES) 14657015 2 50 245 +PRMT5 PRMT5 Cell cycle regulation; EC 2.1.1.125; METHYLTRANSFERASE; Methyltransferase; Methyltransferase, protein arginine; RNA processing O14744 10419 14q11.2 human Y304-p 18545701 YELFAKGyEDYLQSP PRMT5 molecular association, regulation; enzymatic activity, inhibited carcinogenesis, altered; cell growth, altered PRMT5(DISRUPTS) 21316606 1 0 0 contributes to the mutant Jak2 V617F -induced myeloproliferative phenotype; negatively regulates hematopoietic stem/progenitor cell expansion and erythroid differentiation +SRPK2 SRPK2 EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, CMGC; Protein kinase, Ser/Thr (non-receptor) P78362 6733 7q22.3 human S497-p 483632 SRTVSASsTGDLPKA intracellular localization; phosphorylation transcription, induced 29153836 1 47 1 transcription of genes involved in de novo lipid synthesis; nuclear translocation; S494 phosphorylation by S6K1 primes S497 phosphorylation by CK1 +PIDD1 PIDD Q9HB75 55367 11p15.5 human T788-p 25680403 DAETGFLtQSNLLSV molecular association, regulation cell cycle regulation; apoptosis, induced; apoptosis, inhibited; signaling pathway regulation CRADD(INDUCES); RIPK1(DISRUPTS) 22854598; 25301067 2 0 0 Caspase-2 activation, Mdm2 cleavage, increased p53 levels and drug resistance +MYLK smMLCK EC 2.7.11.18; KINASE; Kinase, protein; Protein kinase, CAMK; Protein kinase, Ser/Thr (non-receptor) Q15746 4638 3q21.1 human S343-p 468783 PVLQKTSsSITLQAA 23ISL carcinogenesis, induced; cell motility, induced; cytoskeletal reorganization 35278271 1 10 1 +EGFR EGFR EC 2.7.10.1; KINASE; Kinase, protein; Membrane protein, integral; Oncoprotein; Protein kinase, TK; Protein kinase, tyrosine (receptor) P00533 1956 7p11.2 human K745-ub 27187821 VKIPVAIkELREATS PK_Tyr_Ser-Thr protein stabilization 32669362 1 3 0 SMURF2-UBE2D1 protein?protein interaction affects mutant EGFR levels +CHEK1 Chk1 EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, CAMK; Protein kinase, Ser/Thr (non-receptor); Tumor suppressor O14757 1111 11q24.2 human S345-p 447834 LVQGISFsQPTCPDH protein degradation; protein stabilization; molecular association, regulation; phosphorylation; enzymatic activity, induced; activity, induced; ubiquitination; intracellular localization cell cycle regulation; carcinogenesis, induced; apoptosis, altered; carcinogenesis, inhibited; apoptosis, induced; cell growth, inhibited; transcription, induced; transcription, altered; signaling pathway regulation; DNA repair, induced; cell growth, induced; apoptosis, inhibited; DNA repair, inhibited 14-3-3 sigma(INDUCES); p53(INDUCES); claspin(INDUCES); p21Cip1(INDUCES) DNA(INDUCES) 10859164; 11390642; 11896572; 12588868; 14729972; 15707391; 15870257; 16137618; 17940005; 19091954; 20609246; 21907702; 23684611; 24240236; 24639502; 24876101; 26082189; 27753536; 30001349; 30573684; 31209037; 31597105; 31928997; 32093423; 32357935; 32989256; 33503415; 33692124; 33820915; 33851958; 33857133; 33863777; 34508175; 34509474; 34676045; 34711990; 35348191; 35413091; 35768646; 35951367; 36563124; 36781846 212 5 12 +RB1 Rb Nuclear receptor co-regulator; Oncoprotein; Transcription, coactivator/corepressor; Tumor suppressor P06400 5925 13q14.2 human S249-p 447975 AVIPINGsPRTPRRG activity, induced; protein degradation; acetylation; molecular association, regulation; ubiquitination; activity, inhibited; phosphorylation cell cycle regulation; carcinogenesis, induced; cell growth, inhibited; transcription, induced; transcription, altered; signaling pathway regulation; cell growth, induced; apoptosis, inhibited; transcription, inhibited BRD4(DISRUPTS); E2F1(DISRUPTS); E2F1(INDUCES); EID1(DISRUPTS); HDAC5(DISRUPTS) 17599043; 17996702; 22279936; 27642049; 33419772; 35023164; 36274096; 36637424 19 45 86 +GLI2 GLI2 C2H2-type zinc finger protein; Oncoprotein; Transcription factor P10070 2736 2q14.2 human T1546-p 1874115100 QNSSRLTtPRNSLTL protein stabilization carcinogenesis, induced; cell growth, induced; transcription, induced 34267186 1 1 0 inhibits ubiquitination +HNRNPK hnRNP K RNA splicing; RNA-binding; Spliceosome P61978 3190 9q21.32 human S379-p 483629 SYAGGRGsYGDLGGP cell cycle regulation; cell motility, inhibited 31110205 2 48 4 downregulates Twist, upregulates MMP12, upregulates and stabilizes beta catenin +Tp53 p53 Activator; DNA-binding; Motility/polarity/chemotaxis; Nuclear receptor co-regulator; Transcription factor; Tumor suppressor P02340 22059 11 B3|11 42.83 cM mouse S37-p 1869726220 PPEDILPsPHCMDDL phosphorylation 15794754 4 1 0 S37A mutant abrogates the constitutive phosphorylation at S18 (S15 in human) in the BVE system, but not in the mamalian in vitro expression system +AMOTL2 AMOTL2 Cell adhesion Q9Y2J4 51421 3q22.2 human S759-p 477928 SSSQRAAsLDSVATS molecular association, regulation cell motility, induced; cell growth, induced; transcription, induced YAP1(DISRUPTS) 25998128 1 21 2 +TKT TKT Carbohydrate Metabolism - pentose phosphate pathway; EC 2.2.1.1; Transferase P29401 7086 3p21.1 human T287-p 452283 SKKKILAtPPQEDAP molecular association, regulation; ubiquitination; enzymatic activity, induced carcinogenesis, induced; cell motility, induced; cell growth, induced; transcription, induced; signaling pathway regulation FBXL6(INDUCES) 37653031 1 31 3 regulates the FBXL6-TKT-ROS-mTOR pathway +KDR VEGFR2 EC 2.7.10.1; KINASE; Kinase, protein; Membrane protein, integral; Protein kinase, TK; Protein kinase, tyrosine (receptor) P35968 3791 4q12 human Y1214-p 447902 VCDPKFHyDNTAGIS molecular association, regulation; enzymatic activity, induced carcinogenesis, induced; cell motility, altered; cell motility, inhibited; cytoskeletal reorganization NCK1(INDUCES); Fyn(INDUCES) 14724572; 16966330; 20176926; 35081345 17 4 58 +DNM1L DRP1 Apoptosis; EC 3.6.5.5; Endoplasmic reticulum; Hydrolase; Microtubule-binding; Mitochondrial; Motor O00429 10059 12p11.21 human Y266-p 297110000 TDSIRDEyAFLQKKY Dynamin_M activity, induced 29022905 1 0 0 oxidative stress-induced cell death in primary cortical neuron; increased GTPase activity +GATA3 GATA3 Transcription factor P23771 2625 10p14 human R261-m2 56834500 KARSSTGrECVNCGA molecular association, regulation transcription, inhibited HSP60(INDUCES) 25861992 1 1 0 induce Il-5 transcription +PAX7 PAX7 DNA-binding; Oncoprotein; Transcription factor O42349 395942 chicken K85-sm 27850500 VSHGCVSkILCRYQE PAX cell differentiation, induced; transcription, induced 23247248 1 0 0 regulation of neural crest and muscle development +CAPZA1 CAPZA1 Actin-binding; Motility/polarity/chemotaxis P52907 829 1p13.2 human S9-p 457555 ADFDDRVsDEEKVRI molecular association, regulation; phosphorylation cytoskeletal reorganization PLEKHO1(INDUCES) 15831458 1 23 0 +TLN1 talin 1 Cytoskeletal; Motility/polarity/chemotaxis Q9Y490 7094 9p13.3 human S425-p 1984203 TMLEDSVsPKKSTVL protein stabilization; molecular association, regulation; ubiquitination cell motility, induced; cell adhesion, induced; cell motility, altered; cell adhesion, altered SMURF1(DISRUPTS) 19363486; 24793790 7 44 2 ?1 integrin activation in metastatic PCa cells +ETS2 Ets-2 DNA-binding; Oncoprotein; Transcription factor P15036 2114 21q22.2 human S220-p 30320500 PKGGLLDsMCPASTP protein degradation 24218572; 26871468 2 1 0 CDK10 mediated degradation +CD151 CD151 Membrane protein, integral; Membrane protein, multi-pass P48509 977 11p15.5 human K17-ub 4666604 TCGTVCLkYLLFTYN Tetraspanin protein degradation 18713730 1 0 0 cell surface downregulation of tetraspanins +Nfe2l2 NRF2 DNA-binding; Transcription factor Q60795 18024 2 C3|2 44.75 cM mouse S351-p 18258500 SRASPEHsVESSIYG protein degradation; molecular association, regulation BTRC(INDUCES) 21245377 1 0 0 +HSD17B10 HADH2 Amino Acid Metabolism - valine, leucine and isoleucine degradation; EC 1.1.1.178; EC 1.1.1.35; EC 1.1.1.51; Mitochondrial; Oxidoreductase Q99714 3028 Xp11.22 human K99-ac 1877232021 AGIAVASkTYNLKKG adh_short enzymatic activity, inhibited cell growth, inhibited RG9MTD1(DISRUPTS) 32703935; 32956445 2 0 0 formation of mt-tRNA splicing complex, regulated mitochondrial function, les cell resistance to stress and cell growth ; mt-tRNA splicing complex +Flot2 FLOT2 Cell adhesion Q9Z2S9 83764 10q25 rat Y124-p 1270904 TLTVEQIyQDRDQFA Band_7 cell motility, altered; cytoskeletal reorganization 17213334 1 1 0 +MAFA MAFA DNA-binding; Oncoprotein; Transcription factor; Tumor suppressor O57342 quail T113-p 456029 NPEALNLtPEDAVEA Maf_N cell differentiation, altered; transcription, altered 15963504 4 2 0 +TAX1BP1 TAX1BP1 iso2 Apoptosis Q86VP1-2 8887 7p15.2 human S593-p 12738639 NYKELKRsLENPAER molecular association, regulation; ubiquitination signaling pathway regulation TRAF2(INDUCES); TRAF6(INDUCES) 21765415 1 6 0 regulates NF-kB signaling; ; regulates interaction with A20 and Itch via TRAF2 and TRAF6 +MICAL2 MICAL2 Adaptor/scaffold; EC 1.14.13.- O94851 9645 11p15.3 human Y463-p 1875329208 INKNFEQyTLDPGTR carcinogenesis, induced; cell motility, induced; cell growth, induced; cytoskeletal reorganization 34750518 1 1 0 +Sirt1 SIRT1 Apoptosis; DEACETYLASE; Deacetylase; EC 3.5.1.-; Nuclear receptor co-regulator Q923E4 93759 10|10 B4 mouse S683-p 9993600 EEPLEDEsEIEEFYN enzymatic activity, induced apoptosis, inhibited 19680552 1 0 0 deacetylates p53 K382 and NFkB-p65 +EP300 p300 ACETYLTRANSFERASE; Acetyltransferase; EC 2.3.1.48; Motility/polarity/chemotaxis; Nuclear receptor co-regulator; Transcription, coactivator/corepressor Q09472 2033 22q13.2 human R754-m1 1872472300 PPMGYGPrMQQPSNQ molecular association, regulation cell cycle regulation; DNA repair, induced; transcription, induced BRCA1(INDUCES) 21245169 1 0 0 +Tnni3 TNNI3 Actin-binding; Motility/polarity/chemotaxis; Motor P48787 21954 7 A1|7 2.61 cM mouse S24-p 448424 APVRRRSsANYRAYA Troponin-I_N activity, induced; activity, inhibited; protein conformation; phosphorylation cytoskeletal reorganization 12923217; 15507454; 15774859; 17010989; 17615373; 20083117; 22527640; 8530519 64 12 16 TNNI3 transgenic and gene transfer of S22/23D showed faster relaxation times. ; ROCK II induced desensitization to Ca++ and depression in maximal tension. +Nr0b2 NR0B2 Nuclear receptor; Nuclear receptor co-regulator; Transcription, coactivator/corepressor Q62227 23957 4 D2.3|4 66.25 cM mouse K122-ub 7596701 APVPSILkKILLEEA Hormone_recep protein degradation 19390091 1 0 0 +FOXO1 FOXO1A DNA-binding; Nuclear receptor co-regulator; Oncoprotein; Transcription factor Q12778 2308 13q14.11 human S287-p 478910 GQEGAGDsPGSQFSK intracellular localization transcription, altered 20061393 4 26 1 multiple site mutant (8A) +Egfr EGFR EC 2.7.10.1; KINASE; Kinase, protein; Membrane protein, integral; Oncoprotein; Protein kinase, TK; Protein kinase, tyrosine (receptor) Q01279 13649 11 A2|11 9.41 cM mouse Y1092-p 448057 AFLPVPEyVNQSVPK activity, induced; molecular association, regulation; enzymatic activity, induced; phosphorylation carcinogenesis, induced; carcinogenesis, altered; cell motility, induced; transcription, altered; signaling pathway regulation; cell growth, induced; cell differentiation, induced; apoptosis, inhibited; transcription, inhibited MUC4(INDUCES) 16123117; 21857648; 32197276; 34520454; 34610301; 34620174; 36323264; 36385375; 36624189 177 30 352 +WASF2 WAVE2 Actin-binding; Motility/polarity/chemotaxis Q9Y6W5 10163 1p36.11 human S489-p 6377640 SDSEDDSsEFDEDDW activity, inhibited cytoskeletal reorganization 19012317 1 0 1 +PIK3R1 PIK3R1 KINASE; Kinase, lipid; Motility/polarity/chemotaxis P27986 5295 5q13.1 human Y556-p 459303 LKKQAAEyREIDKRM PI3K_P85_iSH2 molecular association, regulation; enzymatic activity, induced cell motility, altered SHP-2(INDUCES); IRS1(INDUCES) 16306077 1 6 33 +FOXO3 FOXO3A Autophagy; DNA-binding; Oncoprotein; Transcription factor O43524 2309 6q21 human S321-p 453424 NSNASTVsGRLSPIM cell cycle regulation; transcription, inhibited SMAD4(INDUCES); SMAD3(INDUCES) 21532621; 33828192 9 0 0 Regulate cellular senescence in HaCaT cells +SNAI1 Snail1 C2H2-type zinc finger protein; Transcription factor O95863 6615 20q13.13 human T203-p 21400402 QGHVRTHtGEKPFSC activity, induced; protein stabilization; intracellular localization cell cycle regulation; carcinogenesis, induced; cell motility, induced; cell growth, induced; cell motility, altered; transcription, induced; transcription, altered 21952048; 30800215; 34335956 3 0 1 +RBL2 Rb-like 2 Transcription, coactivator/corepressor; Tumor suppressor Q08999 5934 16q12.2 human T694-p 449730 DSPSDGGtPGRMPPQ molecular association, regulation cell cycle regulation E2F4(DISRUPTS) 11157749 3 5 1 +Tfeb TFEB DNA-binding; Transcription factor Q9R210 21425 17 C|17 23.99 cM mouse S466-p 4785142 KASSRRSsFSMEEGD DUF3371 protein stabilization; intracellular localization autophagy, inhibited; transcription, induced 23599343; 28165011 4 20 2 Cellular clearance inhibited +NR4A1 Nur77 Apoptosis; DNA-binding; Nuclear receptor P22736 3164 12q13.13 human S351-p 447942 GRRGRLPsKPKQPPD activity, inhibited; phosphorylation cell motility, induced; cell growth, induced; apoptosis, induced; cytoskeletal reorganization; transcription, inhibited 11274386; 16434970; 26155943 11 4 0 Akt inhibits MEKK1-mediated nuclear export of Nur77 by phosphorylating S351. ; dephosphorylation of S351 is required for increase cell growth, cell motility, monolayer permeability and formation of actin stress fibers. +GAB2 GAB2 Adaptor/scaffold Q9UQC2 9846 11q14.1 human Y476-p 450051 GDNSQSVyIPMSPGA molecular association, regulation PIK3R1(INDUCES) 11334882 1 3 193 +NEK2 NEK2 EC 2.7.11.1; KINASE; Kinase, protein; Nucleolus; Protein kinase, Other; Protein kinase, Ser/Thr (non-receptor) P51955 4751 1q32.3 human S171-p 12574604 RILNHDTsFAKTFVG Pkinase enzymatic activity, induced 17197699 1 5 0 +HNRNPK hnRNP K RNA splicing; RNA-binding; Spliceosome P61978 3190 9q21.32 human R256-m2 6742804 RPVGFPMrGRGGFDR molecular association, regulation translation, inhibited RPS19(INDUCES) 33660773 2 4 1 suppression of ALOX15 mRNA translation initiation +H3C1 H3 DNA-binding P68431 8350 6p22.2 human K9-me 1668801 RTKQTARkSTGGKAP Histone molecular association, regulation; acetylation; intracellular localization; methylation; phosphorylation chromatin organization, altered; transcription, altered; transcription, inhibited DNA(INDUCES); DNA(DISRUPTS) 10949293; 11779497; 12208844; 12482974; 16774942; 17646159; 19010785; 32528962 27 1 0 +MAF MAF Cell development/differentiation; DNA-binding; Oncoprotein; Transcription factor; Tumor suppressor O75444 4094 16q23.2 human K297-ub 56473800 KQKRRTLkNRGYAQS bZIP_Maf protein degradation cell growth, inhibited 26825710 1 0 0 +GYS1 GYS1 Carbohydrate Metabolism - starch and sucrose; EC 2.4.1.11; Transferase P13834 100008660 rabbit S653-p 448240 PSLSRHSsPHQSEDE Glycogen_syn enzymatic activity, inhibited 10909964 13 24 4 +Rasgrf2 RASGRF2 GEF; GEF, Ras P70392 19418 13 C3|13 47.43 cM mouse S737-p 2902208 LAVSRTSsPVRARKL RasGEF_N activity, induced; intracellular localization; phosphorylation 15128856 1 0 0 regulates phosphorylation of MEK and ERK +KCNJ3 GIRK1 Channel, potassium; Membrane protein, integral; Membrane protein, multi-pass P48549 3760 2q24.1 human S385-p 4706226 NSKERHNsVECLDGL activity, induced 19151997 3 4 1 +DTD1 DTD1 DNA replication; EC 3.1.-.-; Hydrolase Q8TEA8 92675 20p11.23 human S179-p 23112003 KTRAKGPsESSKERN molecular association, regulation cell cycle regulation; cell growth, induced MCM7(INDUCES); MCM3(DISRUPTS) 25258324 1 1 1 decreases DTD1 incorporation into HMW, supports DNA replication initiation +NTRK3 TrkC EC 2.7.10.1; KINASE; Kinase, protein; Membrane protein, integral; Protein kinase, TK; Protein kinase, tyrosine (receptor) Q16288 4916 15q25.3 human Y705-p 464876 FGMSRDVySTDYYRL PK_Tyr_Ser-Thr carcinogenesis, induced; cell growth, induced; signaling pathway regulation 10702799 1 2 46 +RELA NFkB-p65 DNA-binding; Nuclear receptor co-regulator; Transcription factor Q04206 5970 11q13.1 human S311-p 449966 RTYETFKsIMKKSPF acetylation; molecular association, regulation; methylation carcinogenesis, induced; carcinogenesis, inhibited; transcription, induced; signaling pathway regulation SETD6(INDUCES); HDAC5(DISRUPTS) DNA(INDUCES) 21515635; 22205033; 23100252; 26729520; 32416562; 33864076; 34230209; 35265200 17 2 1 inhibits deacetylation of itself +Ptprn PTPRN Membrane protein, integral; Motility/polarity/chemotaxis; Receptor protein phosphatase, tyrosine Q60673 19275 1 C4|1 38.64 cM mouse K754-sm 12004423 DHARIKLkVESSPSR Y_phosphatase molecular association, regulation transcription, inhibited STAT5A(DISRUPTS) 16622421 1 0 0 binding to STAT5 prevents STAT5 dephosphorylation +Unc93b1 UNC93B1 Cell surface; Membrane protein, integral; Membrane protein, multi-pass Q8VCW4 54445 19|19 A mouse S547-p 3212115 RYLEEDNsDESDMEG molecular association, regulation signaling pathway regulation syntenin(INDUCES) 31546246 1 25 4 inhibits TLR7 signaling +TAB2 TAB2 Adaptor/scaffold Q9NYJ8 23118 6q25.1 human K562-sm 1877015600 KKKLDKLkSEVNEME molecular association, regulation transcription, inhibited; signaling pathway regulation 33184450 1 0 0 inhibition of TRAF6/TAB2/TAK1 complex and downstream MAPK and NF-?B pathway +CDCA5 CDCA5 Cell cycle regulation Q96FF9 113130 11q13.1 human S139-p 20727378 DARDLEMsKKVRRSY Sororin activity, inhibited cell cycle regulation SCC-112(DISRUPTS) 23901111 1 1 0 +OVAL ovalbumin P01012 396058 chicken S345-p 22689701 AGREVVGsAEAGVDA Serpin protein stabilization 23316083 2 0 0 +KHSRP KHSRP RNA-binding Q92945 8570 19p13.3 human T692-p 458387 QAAYYGQtPGPGGPQ RNA stability, altered 16364914 1 0 0 inhibits degradation of myogenic transcripts during myoblast differentiation +GABBR1 GABBR1 GPCR, family 3; Membrane protein, integral; Membrane protein, multi-pass; Receptor, GPCR Q9UBS5 2550 6p22.1 human K905-ub 54191600 LEKIIAEkEERVSEL protein degradation; ubiquitination 26817839 1 0 0 +CTNNB1 CTNNB1 Actin-binding; Cell adhesion; Motility/polarity/chemotaxis; Nuclear receptor co-regulator; Oncoprotein; Transcription factor P35222 1499 3p22.1 human Y670-p 469563 SEDKPQDyKKRLSVE activity, induced; molecular association, regulation; intracellular localization cell growth, induced; transcription, induced; cell growth, altered LEF-1(DISRUPTS); Met(DISRUPTS); CDH1(DISRUPTS) 16952352; 21423209 3 1 15 +KEAP1 KEAP1 Endoplasmic reticulum; Motility/polarity/chemotaxis; Transcription regulation; UBIQUITIN LIGASE; Ubiquitin conjugating system Q14145 9817 19p13.2 human S104-p 1875847402 KVVLASSsPVFKAMF BTB molecular association, regulation PIN1(INDUCES) 34918396 1 0 0 +FZD6 FZD6 GPCR, Fz/Smo family; Membrane protein, integral; Membrane protein, multi-pass; Receptor, GPCR O60353 8323 8q22.3 human S648-p 1275585104 SVSESARsEGRISPK intracellular localization 30309985 1 1 0 localized in the plasma membrane +CDK9 CDK9 Cell cycle regulation; EC 2.7.11.22; EC 2.7.11.23; KINASE; Kinase, protein; Nuclear receptor co-regulator; Protein kinase, CMGC; Protein kinase, Ser/Thr (non-receptor) P50750 1025 9q34.11 human K44-ac 478252 RHRKTGQkVALKKVL Pkinase molecular association, regulation; intracellular localization; enzymatic activity, inhibited; phosphorylation transcription, induced; transcription, inhibited Other(INDUCES) 17452463; 18250157 3 1 0 induces ATP binding, inhibits phosphorylation of RNA POL II; induces phosphorylation of POLII +CAVIN1 PTRF Transcription initiation complex Q6NZI2 284119 17q21.2 human K296-ac 1873356108 KLKTSRDkLRKSFTP PTRF_SDPR molecular association, regulation; intracellular localization HSL(INDUCES) 28559430 1 1 0 induces lipolysis +CYP19A1 CYP19A1 EC 1.14.14.14; Lipid Metabolism - androgen and estrogen; Oxidoreductase P11511 1588 15q21.2 human Y361-p 10433800 KVMENFIyESMRYQP p450 protein degradation; enzymatic activity, induced 19556341; 31652308 2 1 0 +IRF3 IRF3 DNA-binding; Transcription factor Q14653 3661 19q13.33 human K313-ub 56403901 GPDGEVPkDKEGGVF IRF-3 protein degradation; ubiquitination; intracellular localization autophagy, induced; apoptosis, induced CALCOCO2(INDUCES) 27178468; 32476569; 33513265 3 0 0 +Scn2a SCN2A Channel, sodium; Membrane protein, integral; Membrane protein, multi-pass P04775 24766 3q21 rat Y1893-p 1046201 SNPSKVSyEPITTTL molecular association, regulation; activity, inhibited Fyn(INDUCES) 17959797 1 1 1 +OGG1 OGG1 DNA repair, damage; Deoxyribonuclease; EC 4.2.99.18; Lyase O15527 4968 3p25.3 human S280-p 10036105 HIAQRDYsWHPTTSQ HhH-GPD enzymatic activity, inhibited 19674107 1 0 0 +IBTK IBTK Protein kinase, regulatory subunit Q9P2D0 25998 6q14.1 human S1203-p 15483703 LHSVSSKsFRDFLLE activity, induced; molecular association, regulation; intracellular localization; enzymatic activity, induced Btk(DISRUPTS) 21482705 1 6 0 regulation of the Btk:IBTK complex, induce calcium mobilization and NFkB activation +CMAS CMAS Carbohydrate Metabolism - amino sugar and nucleotide sugar; EC 2.7.7.43; Transferase Q8NFW8 55907 12p12.1 human K399-m1 58123201 DACSTAQkAVGYICK molecular association, regulation L3MBTL iso4(INDUCES) 23583077 0 1 0 +Pxn PXN Adaptor/scaffold; Cell adhesion; Cytoskeletal; Motility/polarity/chemotaxis Q8VI36 19303 5 F|5 56.1 cM mouse Y118-p 448604 AGEEEHVySFPNKQK Paxillin activity, induced; molecular association, regulation; phosphorylation carcinogenesis, induced; apoptosis, altered; cell motility, induced; cell adhesion, induced; cell growth, induced; cell motility, altered; apoptosis, inhibited; cell adhesion, altered; cytoskeletal reorganization RASA1(INDUCES); Vinculin(INDUCES) 12446743; 15107421; 15138291; 20308429; 30604146; 33711252; 36207442; 36997926 83 79 2519 +MYCN N-Myc DNA-binding; Oncoprotein; Transcription factor P04198 4613 2p24.3 human T58-p 448223 KKFELLPtPPLSPSR Myc_N protein degradation; molecular association, regulation; ubiquitination; intracellular localization TRIM32(INDUCES); AurA(INDUCES) 19111882; 25100564; 25175806 7 22 17 Phosphorylation is required and MG-132 protects N-Myc from degradation +Prkca PKCA EC 2.7.11.13; KINASE; Kinase, protein; Oncoprotein; Protein kinase, AGC; Protein kinase, Ser/Thr (non-receptor) P20444 18750 11 E1|11 70.8 cM mouse S657-p 448597 QSDFEGFsYVNPQFV Pkinase_C molecular association, regulation cytoskeletal reorganization; signaling pathway regulation fascin(INDUCES) 18851840; 30683702 28 4 2 +SLC12A2 NKCC1 Membrane protein, integral; Membrane protein, multi-pass; Transporter; Transporter, SLC family P55011 6558 5q23.3 human T212-p 455545 TNTYYLRtFGHNTMD AA_permease_N activity, induced; enzymatic activity, induced 12145304; 12145305; 16669787; 22032326 20 15 13 +Slc2a2 GLUT2 Membrane protein, integral; Membrane protein, multi-pass; Transporter; Transporter, SLC family P12336 25351 2q24 rat S489-p 451344 VPETKGKsFDEIAAE Sugar_tr activity, inhibited 8626492 1 0 0 Phosphorylation reduces the initial rate of 3-O-methyl glucose uptake. +Hdac7 HDAC7 DEACETYLASE; Deacetylase; EC 3.5.1.98; Hydrolase Q8C2B3 56233 15|15 F1 mouse S178-p 455620 FPLRKTVsEPNLKLR molecular association, regulation; intracellular localization 14-3-3 epsilon(DISRUPTS) 16956611; 21399638 9 34 53 phosphorylation excludes HDAC7 from nucleus +SUGT1 SUGT1 Cell cycle regulation; Ubiquitin conjugating system Q9Y2Z0 10910 13q14.3 human S281-p 486562 KNLYPSSsPYTRNWD protein stabilization; molecular association, regulation; intracellular localization cell cycle regulation RNF41(INDUCES) 21864708; 28696259 2 4 9 +XRCC5 Ku80 DNA-binding; EC 3.6.1.-; EC 3.6.4.-; Helicase; Nuclear receptor co-regulator; Nucleolus; RNA-binding P13010 7520 2q35 human K155-ub 15391493 DIIIHSLkKCDISLQ Ku_N molecular association, regulation DNA repair, induced DNA(DISRUPTS) 27895153 1 2 1 +ARHGEF6 ARHGEF6 GEF; GEF, Rac/Rho; Motility/polarity/chemotaxis Q15052 9459 Xq26.3 human S488-p 452424 LSASPRMsGFIYQGK PH activity, induced cell motility, induced; cell growth, induced 25694429 1 80 5 GEF +Gsk3b GSK3B EC 2.7.11.1; EC 2.7.11.26; KINASE; Kinase, protein; Protein kinase, CMGC; Protein kinase, Ser/Thr (non-receptor) Q9WV60 56637 16|16 B3 mouse S21-p 456055 CKPVQQPsAFGSMKV cell differentiation, induced; transcription, induced 34140410 7 1 9 inhibits degradation of ?-catenin +WWOX WWOX Apoptosis; EC 1.1.1.-; Oxidoreductase; Tumor suppressor Q9NZC7 51741 16q23.1-q23.2 human S14-p 454203 AGLDDTDsEDELPPG phosphorylation carcinogenesis, induced; cell motility, induced; cell growth, induced; apoptosis, inhibited; signaling pathway regulation 31752354 2 26 6 pS14-WWOX7-21 peptide treatment increased phosphorylation of Erk1, cell growth (4T1 cells & mice) and metastasis (in mice) +TTC3 TTC3 Cell development/differentiation; EC 6.3.2.-; EC 6.3.2.19; Ligase; UBIQUITIN LIGASE; Ubiquitin conjugating system; Ubiquitin ligase P53804 7267 21q22.13 human S378-p 12473003 AYTPRSLsAPIFTTS ubiquitination; enzymatic activity, induced cell cycle regulation 20059950 1 2 0 facilitates proteasomal degradation of Akt1 +CHEK2 Chk2 EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, CAMK; Protein kinase, Ser/Thr (non-receptor); Tumor suppressor O96017 11200 22q12.1 human S372-p 17534900 KITDFGHsKILGETS Pkinase intracellular localization 20713355 1 1 0 chromatin targeting of S372, S379, T389, singly and T383/389, T378/S379 +Podxl PODXL Cell adhesion; Membrane protein, integral; Motility/polarity/chemotaxis Q9WTQ2 192181 4q22 rat S415-p 21514209 GCCHQRIsQRKDQQR CD34_antigen molecular association, regulation; intracellular localization; enzymatic activity, inhibited; activity, inhibited cytoskeletal reorganization Ezrin(DISRUPTS) 21945805 1 1 0 prevents RhoA and Ezrin activation, alters actin cytoskeleton +Pias2 PIAS2 EC 6.3.2.-; Nuclear receptor co-regulator; SUMO LIGASE; SUMO conjugating system; SUMO ligase; Transcription, coactivator/corepressor Q6AZ28 83422 18q12.3 rat S113-p 464653 STSIAPHsPSSPVAS transcription, altered 16713578 1 0 0 important for Elk1-mediated transcriptional activation +STX17 STX17 Membrane protein, integral; Membrane protein, multi-pass; Vesicle P56962 55014 9q31.1 human Y157-p 479165 SQSLTQIyALPEIPQ molecular association, regulation COPB1(DISRUPTS) 23006999 1 0 1 regulates STX17 dependent membrane trafficking +H1-4 H1E DNA-binding P10412 3008 6p22.2 human K26-m2 6742808 PVKKKARkSAGAAKR molecular association, regulation L3MBTL iso4(INDUCES); CBX3(INDUCES) 19144645 1 1 0 +Lsr LISCH iso2 Membrane protein, integral; Receptor, misc. Q99KG5-2 54135 7|7 B1 mouse Y237-p 463761 CCCPEALyAAGKAAT intracellular localization 31574128 1 5 33 inhibits epithelial barrier function +Mapk3 ERK1 EC 2.7.11.24; KINASE; Kinase, protein; Protein kinase, CMGC; Protein kinase, Ser/Thr (non-receptor) P21708 50689 1q36 rat T208-p 3949243 FLTEYVAtRWYRAPE Pkinase enzymatic activity, induced 26658610 2 13 31 +Prkd1 PRKD1 Autophagy; EC 2.7.11.13; KINASE; Kinase, protein; Motility/polarity/chemotaxis; Protein kinase, CAMK; Protein kinase, Ser/Thr (non-receptor) Q62101 18760 12|12 B3 mouse S748-p 448590 GEKSFRRsVVGTPAY Pkinase activity, induced; enzymatic activity, induced 10473617; 10867018; 12407104; 15084589; 15590638; 15623513; 34478715 56 49 53 +GMNN Geminin Cell cycle regulation; Motility/polarity/chemotaxis O75496 51053 6p22.3 human Y150-p 33402208 EVAEHVQyMAELIER Geminin protein stabilization carcinogenesis, induced; cell growth, induced; apoptosis, inhibited 24789045 1 0 0 induces aneuploidy, promotes transformation +Myb Myb DNA-binding; Oncoprotein; Transcription factor P06876 17863 10 A3|10 9.75 cM mouse K499-sm 486351 EDLQDVIkQESDESG Cmyb_C protein stabilization; intracellular localization transcription, inhibited 11779867; 16162816; 17077080 5 0 0 slight increase in conjugation of two and three molecules of SUMO-2 with S528A phospho-mutant under stress +Kcnb1 Kv2.1 Channel, cation; Channel, ligand-gated; Channel, potassium; Membrane protein, integral; Membrane protein, multi-pass P15387 25736 3q42 rat S804-p 473562 ESSPLPTsPKFLRPN activity, induced; molecular association, regulation; intracellular localization apoptosis, induced; signaling pathway regulation CAMK2A(INDUCES); STX1B(INDUCES) 17360683; 23918396 8 8 0 +BANF1 BAF DNA-binding O75531 8815 11q13.1 human T3-p 7105313 _____MTtSQKHRDF BAF molecular association, regulation; intracellular localization; protein conformation DNA(INDUCES); DNA(DISRUPTS) 16495336; 24600006; 24945635; 33744941; 36402223 6 9 0 +PEAK3 PEAK3 Q6ZS72 374872 19p13.3 human Y24-p 1876371802 TWSTQPTySNLGQIR molecular association, regulation carcinogenesis, induced; cell motility, induced; cell growth, induced; signaling pathway regulation GRB2(INDUCES); CDK6(INDUCES) 35192416 1 1 0 regulates cell invasion through the PEAK3/Grb2/ASAP1 signaling axis +Ppp1ca PPP1CA EC 3.1.3.16; Nucleolus; PHOSPHATASE; Protein phosphatase, Ser/Thr (non-receptor) P62137 19045 19|19 A mouse T320-p 448686 NPGGRPItPPRNSAK intracellular localization 9122166 24 43 98 +SNCA SNCA Adaptor/scaffold P37840 6622 4q22.1 human Y39-p 3546424 KTKEGVLyVGSKTKE Synuclein protein stabilization; molecular association, regulation; phosphorylation apoptosis, altered HSP90B(DISRUPTS); SKP1A(DISRUPTS); SNCA(DISRUPTS); DRBP1(INDUCES); HSC70(DISRUPTS) 18238775; 24412932; 28636593; 31802003; 36690898 9 4 11 decreases phosphorylation of S129 SNCA +SCRIB Scribble Cell adhesion; Motility/polarity/chemotaxis Q14160 23513 8q24.3 human S1508-p 480131 WRAARMKsLEQDALR intracellular localization cell motility, induced; cell adhesion, induced 33583073 2 49 80 +Ceacam1 CEACAM1 Cell adhesion; Immunoglobulin superfamily; Membrane protein, integral; Motility/polarity/chemotaxis P16573 81613 1q21 rat S503-p 448536 QQSKRPTsASSSPTE activity, induced; receptor internalization, altered; intracellular localization 10581007; 11850617; 7518458; 7626603 11 2 0 site directed mutagenesis of this site and T502 nearly abrogates the bile acid efflux activity of CEACAM1; increases insulin receptor internalization and insulin clearance from blood; Phosphorylation of CEACAM1 induces Ca2+/Mg2+-dependent ecto ATPase activity. +Csf2rb CSF2RB Membrane protein, integral; Receptor, cytokine P26955 12983 15 E1|15 37.36 cM mouse Y595-p 450103 SFDFNGPyLGPPQSH molecular association, regulation cell growth, altered SHC1(INDUCES); PIK3R1(INDUCES) 16437163 12 0 0 Phosphorylation of Y595 and S603 are exclusive. Y595 phosphorylation induces binding to Shc and prevents binding to 14-3-3. +PPP1R2 PPP1R2 Inhibitor; Motility/polarity/chemotaxis; Protein phosphatase, regulatory subunit P41236 5504 3q29 human S87-p 449054 GDDEDACsDTEATEA IPP-2 intracellular localization 9405437 4 15 4 Phosphorylation is required for nuclear localization during S phase. +ZC3HC1 NIPA Cell cycle regulation; Ubiquitin conjugating system Q86WB0 51530 7q32.2 human S370-p 483745 RPEPEAAsPTTRTRP molecular association, regulation; intracellular localization cell growth, induced NPM-ALK(DISRUPTS) 31434245 2 37 18 +CLDN2 Claudin-2 Cytoskeletal; Membrane protein, integral; Membrane protein, multi-pass P57739 9075 Xq22.3 human S208-p 21690001 QPLATRSsPRPGQPP intracellular localization 24907662 2 4 0 decreased nuclear and increased cytoplasmic localization +P2ry2 P2Y2 GPCR, family 1; Membrane protein, integral; Membrane protein, multi-pass; Receptor, GPCR; Receptor, misc. P41232 29597 1q32 rat S354-p 2909202 RKDLSISsDDSRRTE receptor internalization, induced 31289122 2 0 0 Regulates ATP induced calcium response +TTK TTK Cancer Testis Antigen (CTA); EC 2.7.12.1; KINASE; Kinase, protein; Protein kinase, Other; Protein kinase, dual-specificity (non-receptor) P33981 7272 6q14.1 human T210-p 41389703 LSASTVLtAQESFSG intracellular localization; enzymatic activity, induced 26119734 1 1 0 regulates spindle assembly checkpoint and recruitment of SAC proteins +MARCKS MARCKS Actin-binding; Motility/polarity/chemotaxis P29966 4082 6q21 human S159-p 447786 KKKKKRFsFKKSFKL MARCKS exocytosis, inhibited 21762971 26 15 10 induce MUC5AC secretion by cold +AHR AHR DNA-binding; Transcription factor P35869 196 7p21.1 human S727-p 1874101930 PMGSFEPsPYPTTSS protein degradation; ubiquitination autophagy, induced; transcription, induced 34198826 1 0 0 +SMAD3 SMAD3 DNA-binding; Nuclear receptor co-regulator; Transcription factor P84022 4088 15q22.33 human K20-ac 1881518201 KRLLGWKkGEQNGQE carcinogenesis, induced; transcription, induced 34392614 1 0 0 upregulates immune response-related cytokines, recruits myeloid-derived suppressor cells and promotion of metastasis +DGCR8 DGCR8 Nucleolus; RNA processing; RNA-binding Q8WYQ5 54487 22q11.21 human T125-p 59186600 VKISVSFtESCRSKD protein stabilization 24239349 0 1 0 +BECN1 beclin 1 Adaptor/scaffold; Autophagy; Membrane protein, peripheral Q14457 8678 17q21.31 human T108-p 29606706 GEASDGGtMENLSRR BH3 molecular association, regulation; intracellular localization apoptosis, induced; autophagy, inhibited Bcl-2(INDUCES); beclin 1(INDUCES); Bcl-xL(INDUCES) 24141421 1 1 0 +DNM1 DYN1 EC 3.6.5.5; Hydrolase; Microtubule-binding; Motility/polarity/chemotaxis; Motor; Vesicle Q05193 1759 9q34.11 human S774-p 450205 SVPAGRRsPTSSPTP activity, induced; activity, inhibited endocytosis, induced; endocytosis, inhibited 26139537; 29695509 14 34 21 +CALD1 Caldesmon Actin-binding P12957 373965 chicken S702-p 456707 GLKVGVSsRINEWLT Caldesmon molecular association, regulation Calmodulin(DISRUPTS) 20858431 5 1 0 +Grin2a NMDAR2A Channel, ligand-gated; Membrane protein, integral; Membrane protein, multi-pass Q00959 24409 10q11 rat S1416-p 455790 ASYCSRDsRGHSDVY NMDAR2_C molecular association, regulation CAMK2A(DISRUPTS) 11104776 1 0 0 +CEP250 CEP250 Cell cycle regulation Q9BV73 11190 20q11.22 human S2064-p 1869636100 REQLLEKsLAQRVQE cytoskeletal reorganization 32606248 1 0 0 regulates centrosome-seperation +OPRD1 DOR-1 GPCR, family 1; Membrane protein, integral; Membrane protein, multi-pass; Receptor, GPCR P41143 4985 1p35.3 human S363-p 448550 RVTACTPsDGPGGGA receptor inactivation, induced; receptor internalization, induced; receptor desensitization, altered; receptor internalization, altered 10893226; 17322005; 32444688 12 1 0 +Sting1 STING Apoptosis; Endoplasmic reticulum; Membrane protein, integral; Membrane protein, multi-pass; Mitochondrial Q3TBT3 72512 18 B2|18 mouse K337-sm 59117705 RHIRQEEkEEVTMNA activity, induced; protein stabilization STING(INDUCES) 27637147 1 0 0 regulates the stability of activated cGas; K337 of Sting promotes its stability, activation, oligomerization, and Irf3 recruitment. +UGT2B7 UGT2B7 Carbohydrate Metabolism - ascorbate and aldarate; Carbohydrate Metabolism - pentose and glucuronate interconversions; Carbohydrate Metabolism - starch and sucrose; Cofactor and Vitamin Metabolism - porphyrin and chlorophyll; Cofactor and Vitamin Metabolism - retinol; EC 2.4.1.17; Lipid Metabolism - androgen and estrogen; Membrane protein, integral; Transferase; Xenobiotic Metabolism - drug metabolism - cytochrome P450; Xenobiotic Metabolism - drug metabolism - other enzymes; Xenobiotic Metabolism - metabolism by cytochrome P450 P16662 7364 4q13.2 human Y236-p 7378200 MKKWDQFySEVLGRP UDPGT enzymatic activity, induced 19289110 2 0 0 +CANX Calnexin Calcium-binding; Endoplasmic reticulum; Membrane protein, integral; Motility/polarity/chemotaxis P24643 dog S555-p 456359 KLEEKQKsDAEEDGG molecular association, regulation; intracellular localization PACS2(DISRUPTS) 18417615 3 88 73 +PAK4 PAK4 EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, STE; Protein kinase, Ser/Thr (non-receptor) O96013 10298 19q13.2 human S291-p 2192537 PGPPGPRsPQREPQR carcinogenesis, induced; cell growth, induced; signaling pathway regulation 34262144 1 29 5 ?-catenin/c-Myc, MEK/ERK signaling pathway +Mrtfa MKL1 Oncoprotein; Transcription, coactivator/corepressor Q8K4J6 223701 15|15 E1 mouse T488-p 469405 KFGSTGStPPVSPTP transcription, induced 33171330 1 43 24 regulates the expression of IL-6; regulates re-endothelialization +Egfr EGFR EC 2.7.10.1; KINASE; Kinase, protein; Membrane protein, integral; Oncoprotein; Protein kinase, TK; Protein kinase, tyrosine (receptor) Q01279 13649 11 A2|11 9.41 cM mouse Y1197-p 448060 PTAENAEyLRVAPPS carcinogenesis, induced; cell motility, induced; cell growth, induced; apoptosis, inhibited; transcription, inhibited; signaling pathway regulation 16123117; 23652203; 34620174; 36323264; 36385375 106 59 1028 +KPNA2 KPNA2 Karyopherin; Nuclear import; Nucleoporin P52292 3838 17q24.2 human T9-p 11536044 STNENANtPAARLHR molecular association, regulation; intracellular localization cell cycle regulation; chromatin organization, altered NuMA-1(DISRUPTS); TPX2(DISRUPTS); KPNB1(DISRUPTS); KIFC1(DISRUPTS) 31434716 1 9 0 +CYCS CYCS Apoptosis; Mitochondrial; Oxidoreductase; PHOSPHATASE; Protein phosphatase, Ser/Thr (non-receptor) P00004 100053958 horse K87-ac 1186609 KMIFAGIkKKTERED Cytochrom_C enzymatic activity, induced 19645667 1 3 20 +ERBB4 HER4 EC 2.7.10.1; KINASE; Kinase, protein; Membrane protein, integral; Protein kinase, TK; Protein kinase, tyrosine (receptor) Q15303 2066 2q34 human Y1128-p 461025 EDSSTQRySADPTVF molecular association, regulation Src(INDUCES); STAT1(INDUCES) 18721752 0 1 1 +H2AC11 H2A.1 DNA-binding P0C0S8 8329 6p22.1 human K15-ac 55610201 GKARAKAkTRSSRAG Histone intracellular localization cell cycle regulation; DNA repair, induced 27153538 3 0 0 +RET Ret EC 2.7.10.1; KINASE; Kinase, protein; Membrane protein, integral; Oncoprotein; Protein kinase, TK; Protein kinase, tyrosine (receptor) P07949 5979 10q11.21 human Y1015-p 449894 MMVKRRDyLDLAAST transcription, altered; cell growth, altered 12444552; 14981541 12 0 0 +Irak1 IRAK1 EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, Ser/Thr (non-receptor); Protein kinase, TKL Q62406 16179 X A7.3|X 37.61 cM mouse K134-ub 2134713 AGDWSPRkLQSSAST protein degradation signaling pathway regulation 29038250 3 0 0 activation of TLR9 ligand-induced inflammatory signaling +Ifi204 IFI16 iso6 Transcription factor P0DOV2_VAR_I158S 15951 1 H3|1 80.63 cM mouse S158-p 1848001 STAQKRKsMREEETG intracellular localization 18165224 1 1 0 +USP22 USP22 Cell cycle regulation; DEUBIQUITINASE; EC 3.4.19.12; Nuclear receptor co-regulator; Protease; Transcription, coactivator/corepressor; Ubiquitin conjugating system; Ubiquitin-specific protease Q9UPT9 23326 17p11.2 human K129-ac 11316055 KDMEIIAkEEQRKAW molecular association, regulation; enzymatic activity, induced ataxin-7L3(INDUCES); GCN5(INDUCES) 23382074 1 1 0 +Abl1 Abl EC 2.7.10.2; KINASE; Kinase, protein; Oncoprotein; Protein kinase, TK; Protein kinase, tyrosine (non-receptor) P00520 11350 2 21.86 cM|2 B mouse Y226-p 450303 KRNKPTIyGVSPNYD phosphorylation; enzymatic activity, induced carcinogenesis, induced; translation, induced 10964922; 11847100; 12748290; 36044842 28 12 304 induces YB1 phosphorylation +Notch1 Notch 1 Membrane protein, integral; Motility/polarity/chemotaxis; Oncoprotein; Receptor, misc.; Transcription factor Q01705 18128 2 A3|2 18.91 cM mouse K1772-ac 18899503 VSEASKKkRREPLGE protein stabilization; ubiquitination 21499261 1 1 0 +SMAD3 SMAD3 DNA-binding; Nuclear receptor co-regulator; Transcription factor P84022 4088 15q22.33 human S423-p 448335 SPSIRCSsVS_____ activity, induced; intracellular localization; protein conformation carcinogenesis, induced; cell differentiation, induced; cell motility, altered; transcription, induced; transcription, altered; signaling pathway regulation 19115199; 21148321; 31995604; 34003249; 35075279; 36461015; 9380693 39 0 5 The triple mutants(S422/423/425A and S422/423/425D) were used in these experiments +DEF6 DEF6 GEF; GEF, Rac/Rho Q9H4E7 50619 6p21.31 human T595-p 5750922 WGSQGNRtPSPNSNE activity, induced; molecular association, regulation transcription, induced IP3R1(INDUCES) 28993769 1 5 30 TCR stimulation-induced activation of NFAT, IL2, and IFNG, FasLG, CTLA4 and CD25 transcription +RND3 RhoE G protein; G protein, monomeric; G protein, monomeric, Rho; Motility/polarity/chemotaxis P61587 390 2q23.3 human S240-p 27933601 LRKDKAKsCTVM___ molecular association, regulation; intracellular localization cell cycle regulation; cytoskeletal reorganization 14-3-3 beta(INDUCES); 14-3-3 zeta(INDUCES) 23622247; 32041905 2 1 0 +RBBP8 CtIP EC 3.1.-.-; Transcription, coactivator/corepressor Q99708 5932 18q11.2 human S723-p 4766312 EERKMNDsLEDMFDR cell cycle regulation; DNA repair, inhibited 30202980 1 13 0 supress DSB end resection +SUZ12 SUZ12 C2H2-type zinc finger protein; Oncoprotein; Transcription factor Q15022 23512 17q11.2 human S541-p 3208749 KRTKASMsEFLESED molecular association, regulation; ubiquitination EZH2(DISRUPTS) 25855382 1 8 0 +MRE11 MRE11A Cell cycle regulation; DNA repair, damage; DNA-binding; Deoxyribonuclease P49959 4361 11q21 human R587-m2 62978400 RGQNSASrGGSQRGR DNA repair, altered 15741314 1 1 0 +ERBB2 HER2 EC 2.7.10.1; KINASE; Kinase, protein; Membrane protein, integral; Oncoprotein; Protein kinase, TK; Protein kinase, tyrosine (receptor) P04626 2064 17q12 human T686-p 451817 QQKIRKYtMRRLLQE receptor internalization, altered; intracellular localization; enzymatic activity, inhibited; phosphorylation AP2A1(NOT_REPORTED); SHP-2(NOT_REPORTED) 18799465; 26676300; 9855018 6 1 0 +RRM1 RRM1 DNA replication; EC 1.17.4.1; Nucleotide Metabolism - purine; Nucleotide Metabolism - pyrimidine; Other Amino Acids Metabolism - glutathione; Oxidoreductase P23921 6240 11p15.4 human S559-p 31890671 PYETYEGsPVSKGIL Ribonuc_red_lgC activity, induced; molecular association, regulation; enzymatic activity, induced cell cycle regulation; carcinogenesis, altered RFA2(DISRUPTS) 32712628 1 1 0 regulation of DNA replication, dNTP levels and genomic stability; induce RNR activity +Cpt1a CPT1A EC 2.3.1.21; Lipid Metabolism - fatty acid; Membrane protein, integral; Membrane protein, multi-pass; Mitochondrial; Transferase P32198 25757 1q42 rat S747-p 479871 FSSPETDsHRFGKHL Carn_acyltransf enzymatic activity, induced 15247243 1 1 0 in vitro +NRIP1 RIP140 Nuclear receptor co-regulator; Transcription, coactivator/corepressor P48552 8204 21q11.2-q21.1 human K1154-sm 2798319 LGSVLTIkKESE___ NRIP1_repr_4 intracellular localization transcription, inhibited 18211901 1 0 0 +CHKA CHKA EC 2.7.1.32; EC 2.7.1.82; Kinase, other; Lipid Metabolism - glycerophospholipid P35790 1119 11q13.2 human Y197-p 21041606 RSLGPKLyGIFPQGR Choline_kinase molecular association, regulation; enzymatic activity, induced carcinogenesis, induced; cell growth, induced; transcription, induced; translation, induced EGFR(INDUCES) 21822308 1 1 0 increases CHKA protein levels +Bsn BSN Cytoskeletal O88778 29138 8q32 rat S2845-p 456576 KTLQRSLsDPKPLSP molecular association, regulation neural plasticity 14-3-3 eta(INDUCES) 23516560 2 18 1 +Arhgdia RhoGDI alpha Apoptosis; Cell adhesion; Cell development/differentiation; G protein regulator, misc.; Motility/polarity/chemotaxis Q5XI73 360678 10q32.3 rat S34-p 467490 YKPPAQKsIQEIQEL Rho_GDI molecular association, regulation cell growth, altered RAC1(DISRUPTS); CDC42 iso1(DISRUPTS) 19103160 5 28 0 in response to bFGF stimulation +NBN NBS1 Cell cycle regulation; DNA repair, damage O60934 4683 8q21.3 human K544-ac 487512 SKSHAAEkLRSNKKR phosphorylation cell cycle regulation; apoptosis, induced 17612497 2 3 19 inhibits phosphorylation at S343 +SHC1 SHC1 iso2 Adaptor/scaffold; Apoptosis; Mitochondrial; Motility/polarity/chemotaxis P29353-2 6464 1q21.3 human Y317-p 448511 ELFDDPSyVNVQNLD activity, induced; molecular association, regulation; phosphorylation cell differentiation, altered; cell growth, induced; cell motility, altered; apoptosis, inhibited; cytoskeletal reorganization; signaling pathway regulation; cell growth, altered SOS1(INDUCES); GRB2(INDUCES); SHIP(INDUCES); ZAP70(INDUCES); PIK3R1(INDUCES); VAV1(INDUCES) 10598576; 10891441; 12237775; 17537990; 9121430; 9566877; 9741627; 9813159 42 91 1971 Y317F Shc did not activate MAPK; ERK phosphorylation; f-actin cytoskeleton, chemotaxis.; activation of Ras/MAPK pathway +Dctn1 dynactin 1 Microtubule-binding; Motility/polarity/chemotaxis; Motor P28023 29167 4q34 rat S19-p 455515 TPSGSRMsTEASARP cytoskeletal reorganization 12119357 2 1 0 +STAT2 STAT2 DNA-binding; Transcription factor P52630 6773 12q13.3 human S381-p 1869778700 RKFNILTsNQKTLTP STAT_bind protein degradation; molecular association, regulation; ubiquitination carcinogenesis, inhibited; cell growth, inhibited; signaling pathway regulation FBXW7(INDUCES) 31843895 1 0 0 by FBXW7 interaction; FBXW7-STAT2 interaction regulate melanoma cell and colony growth +HDAC7 HDAC7 DEACETYLASE; Deacetylase; EC 3.5.1.98; Hydrolase Q8WUI4 51564 12q13.11 human S181-p 470131 NPLLRKEsAPPSLRR intracellular localization transcription, induced 17962809 2 24 18 +MCL1 MCL1 Apoptosis; Channel, misc.; Inhibitor; Membrane protein, integral; Mitochondrial Q07820 4170 1q21.2 human T156-p 59032200 ESGNNTStDGSLPST protein stabilization 27738316 1 0 0 +HNRNPK hnRNP K RNA splicing; RNA-binding; Spliceosome P61978 3190 9q21.32 human Y458-p 465997 LQNSVKQySGKFF__ molecular association, regulation RNA(DISRUPTS) 24642125 2 1 31 UCP2 mRNA +DVL2 DVL2 Adaptor/scaffold; Motility/polarity/chemotaxis O14641 1856 17p13.1 human S143-p 7320089 FHPNVSSsHENLEPE Dishevelled molecular association, regulation; intracellular localization cell cycle regulation; carcinogenesis, induced; apoptosis, inhibited; cytoskeletal reorganization; signaling pathway regulation PLK1(INDUCES) 22609948; 29426949; 31579410 4 3 1 Wnt/?-catenin signaling; 1) Ciliogenesis 2) Association with centrosome and basal bodies of cilia 3) Control homeostasis of DVL2 phosphorylation during ciliogenesis.; important for cilia resorption +PDHA1 PDHA1 Amino Acid Metabolism - valine, leucine and isoleucine biosynthesis; Carbohydrate Metabolism - butanoate; Carbohydrate Metabolism - citrate (TCA) cycle; Carbohydrate Metabolism - glycolysis and gluconeogenesis; Carbohydrate Metabolism - pyruvate; EC 1.2.4.1; Mitochondrial; Oxidoreductase P08559 5160 Xp22.12 human S293-p 448258 TYRYHGHsMSDPGVS E1_dh activity, induced; molecular association, regulation; acetylation; intracellular localization; enzymatic activity, inhibited; activity, inhibited carcinogenesis, induced; cell motility, induced; cell growth, induced; apoptosis, inhibited emerin(INDUCES) 11092882; 17065338; 17474719; 22289032; 25237928; 25243911; 25404640; 27357730; 27498883; 30700909; 30745576; 30797950; 30842661; 31088833; 32737469; 34667275; 35656815; 36071546; 7782287 96 108 675 +HNRNPUL1 E1B-AP5 RNA splicing; RNA-binding Q9BUJ2 11100 19q13.2 human R661-m1 15493497 NYRGGFNrSGGGGYS molecular association, regulation; intracellular localization NBS1(INDUCES) 26020839 1 4 18 ecruitment at sites of damage +KLF13 KLF13 C2H2-type zinc finger protein; DNA-binding Q9Y2Y9 51621 15q13.3 human K180-ac 460600 GCEKVYGkSSHLKAH zf-C2H2 molecular association, regulation DNA(DISRUPTS) 12758070 1 0 0 +TPR TPR Membrane protein, peripheral; Nuclear envelope; Nucleoporin; Oncoprotein P12270 7175 1q31.1 human S2073-p 468981 QAPRAPQsPRRPPHP molecular association, regulation; intracellular localization cell cycle regulation Mad1(INDUCES) 24938596 1 40 3 colocalization with chromatin during telophase +STING1 STING Apoptosis; Endoplasmic reticulum; Membrane protein, integral; Membrane protein, multi-pass; Mitochondrial Q86WV6 340061 5q31.2 human Y245-p 1869808400 RVYSNSIyELLENGQ TMEM173 molecular association, regulation; protein stabilization; intracellular localization; phosphorylation autophagy, inhibited; transcription, induced; signaling pathway regulation IRF3(INDUCES) 31527250; 32926474; 34933455 4 2 0 +Prkcd PKCD EC 2.7.11.13; KINASE; Kinase, protein; Nuclear receptor co-regulator; Protein kinase, AGC; Protein kinase, Ser/Thr (non-receptor); Protein kinase, tyrosine (non-receptor); Tumor suppressor P28867 18753 14 B|14 18.82 cM mouse Y523-p 450231 EILQGLKySFSVDWW Pkinase intracellular localization; phosphorylation; enzymatic activity, induced 27531930 4 0 0 phosphorylation of PKCG, localization of PKCD and PKCG +Ubtf UBF DNA-binding; Nucleolus; Transcription factor P25977 25574 10q32.1 rat S389-p 450170 INKKQTTsPASKKPS molecular association, regulation transcription, induced; transcription, altered POLR1A(INDUCES); TIF1B(INDUCES); p14ARF(DISRUPTS) 17182730; 20943765 4 3 1 +RAP1A RAP1A G protein; G protein, monomeric; G protein, monomeric, Ras; Motility/polarity/chemotaxis; Tumor suppressor P62834 5906 1p13.2 human S11-p 13310084 YKLVVLGsGGVGKSA Ras molecular association, regulation; protein conformation signaling pathway regulation RAF1(INDUCES) 30154518 1 6 1 affects MAPK pathway +RAP1B RAP1B G protein; G protein, monomeric; G protein, monomeric, Ras P61224 5908 12q15 human S180-p 22689703 GKARKKSsCQLL___ molecular association, regulation RAP1GDS1(DISRUPTS) 27760305 4 0 0 inhibits the prenylation of Rap1B +RAPGEF2 RAPGEF2 GEF; GEF, Ras; Motility/polarity/chemotaxis Q9Y4G8 9693 4q32.1 human S1248-p 30995200 AADSGRGsWTSCSSG protein degradation; molecular association, regulation; ubiquitination; enzymatic activity, inhibited carcinogenesis, induced; cell motility, induced BTRC(INDUCES) 24290981 1 0 0 inhibits Rap1 activity +PIP4K2B PIP4K2B Carbohydrate Metabolism - inositol phosphate; EC 2.7.1.149; Kinase, lipid; Motility/polarity/chemotaxis P78356 8396 17q12 human S326-p 470107 SYGTPPDsPGNLLSF PIP5K enzymatic activity, inhibited 16949365 1 11 13 +RUNX2 AML3 DNA-binding; Transcription factor Q13950 860 6p21.1 human S378-p 1867984202 SDPRQFPsISSLTES cell differentiation, inhibited; transcription, inhibited 30910359 1 1 0 in C2C12 cells +Akap12 AKAP12 Adaptor/scaffold Q5QD51 83425 1q11 rat S515-p 469988 SSGLKKLsGKKQKGK molecular association, regulation cell cycle regulation CCNE1(DISRUPTS); CCND1(DISRUPTS) 10982843; 11820772 2 1 0 shown with PKC phosphorylated and nonphosphorylated AKAP12; in vivo permeable peptide/phosphopeptide experiments +GABRB3 GABRB3 Channel, chloride; Channel, ligand-gated; Membrane protein, integral; Membrane protein, multi-pass; Transporter; Transporter, ion channel P28472 2562 15q12 human S433-p 450246 THLRRRSsQLKIKIP Neur_chan_memb receptor internalization, inhibited apoptosis, inhibited 24513087 13 0 3 +TET3 TET3 EC 1.14.11.n2; Oxidoreductase O43151 200424 2p13.1 human K994-ub 38497601 SMYFNGCkYARSKTP Tet_JBP intracellular localization; enzymatic activity, induced 25557551 1 0 0 +BCR Bcr EC 2.7.11.1; GAP; GAP, Rac/Rho; GEF, Rac/Rho; KINASE; Kinase, protein; Oncoprotein; Protein kinase, Ser/Thr (non-receptor); Protein kinase, atypical P11274 613 22q11.23 human Y177-p 447792 ADAEKPFyVNVEFHH molecular association, regulation; phosphorylation carcinogenesis, induced; cell growth, induced; cell motility, altered; apoptosis, inhibited; cell growth, altered GPR89A(INDUCES); GRB2(INDUCES); Hck(DISRUPTS); ECSIT(INDUCES); PLCG1(INDUCES); SHP-2(INDUCES); USP15(INDUCES); SOS1(INDUCES); GAB1(INDUCES); GAB2(INDUCES) 12124177; 35574218; 8112292; 8955135; 9178913; 9407116; 9747873 14 30 1018 regulates phosphorylation of downstream proteins; Grb2 binding site regulates tyrosine phosphorylation of Gab2. +MDC1 MDC1 Cell cycle regulation Q14676 9656 6p21.33 human S218-p 4213800 PFAFNLNsDTDVEEG molecular association, regulation cell cycle regulation NBS1(INDUCES) 18678890 1 1 6 MDC1-NBS1 interaction regulates intra-S-phase checkpoint activation +VIM Vimentin Cytoskeletal; Motility/polarity/chemotaxis P08670 7431 10p13 human S34-p 455454 SRSYVTTsTRTYSLG Filament_head activity, induced carcinogenesis, induced; cell motility, induced; cytoskeletal reorganization; transcription, altered 33525953 3 10 0 Regulates VIF dynamics +HDAC1 HDAC1 DEACETYLASE; Deacetylase; EC 3.5.1.98; Hydrolase; Nuclear receptor co-regulator P56517 373961 chicken S410-p 3195752 KRISIRNsDKRISCD protein stabilization; molecular association, regulation transcription, induced MBD3(DISRUPTS); HDAC2(INDUCES); MTA1(DISRUPTS) 33596269 1 6 0 no effect on homodimerization +Rab3ip RAB3IP GEF; GEF, Rab Q62739 29885 7q22 rat S19-p 37039803 VNLASPTsPDLLGVC activity, induced; molecular association, regulation; protein conformation; enzymatic activity, induced exocytosis, induced RAB11A(DISRUPTS); RAB8A(INDUCES) 25535387 1 0 0 induces GEF activity of RAB3IP, induces RAB8 activity +PTPN6 SHP-1 EC 3.1.3.48; Motility/polarity/chemotaxis; PHOSPHATASE; Protein phosphatase, tyrosine (non-receptor) P29350 5777 12p13.31 human S556-p 15406102 HAKASRTsSKHKEDV enzymatic activity, induced cell adhesion, induced; signaling pathway regulation 21177494 1 2 5 Src activation via SHP-1 and SHP-2, and then ERK activation +Sirt2 SIRT2 iso2 DEACETYLASE; Deacetylase; EC 3.5.1.- Q8VDQ8-2 64383 7|7 B1 mouse S332-p 482809 PNPSTTIsPGKSPPP signaling pathway regulation 24013120 7 31 0 suppresses cell death and in?ammation and neurotoxicity in microglia +DHCR24 Diminuto EC 1.3.1.72; Lipid Metabolism - steroid biosynthesis; Membrane protein, integral; Oxidoreductase Q15392 1718 1p32.3 human Y299-p 473187 KLNSIGNyYKPWFFK protein stabilization; enzymatic activity, induced 24363437 1 0 1 +FANCI FANCI Cell cycle regulation; DNA repair, damage Q9NVI1 55215 15q26.1 human S565-p 114809700 CSQSLSVsQVHVDVH FANCI_HD2 molecular association, regulation; ubiquitination DNA(INDUCES) 28636932; 32117957 2 1 0 prevents deubiquitination of FANCD2 +SH3GLB1 endophilin B1 Apoptosis; Autophagy; EC 2.3.1.-; Mitochondrial; Transferase Q9Y371 51100 1p22.3 human Y80-p 465105 ARIEEFVyEKLDRKA BAR molecular association, regulation apoptosis, inhibited BAX(DISRUPTS) 18474606 1 9 267 +MAPT Tau iso8 ACETYLTRANSFERASE; Acetyltransferase; Cytoskeletal P10636-8 4137 17q21.31 human S258-p 487453 PDLKNVKsKIGSTEN Tubulin-binding molecular association, regulation 21204788 2 1 0 in vitro microtubule binding +COIL coilin Oxidoreductase P38432 8161 17q22 human S271-p 3190114 VTLEARNsSEKLPTE cell growth, inhibited 21991343 1 21 0 Cajal body formation, phosphomutant cell lines show a significant reduction in CB formation compared to wild-type after endogenous coilin knockdown +CALM1 Calmodulin Calcium-binding; Protein phosphatase, regulatory subunit P0DP23 801 14q32.11 human S102-p 448706 KDGNGYIsAAELRHV EF-hand_7 protein conformation 26675311 7 27 40 +PTTG1 Securin Cell cycle regulation; Oncoprotein O95997 9232 5q33.3 human K9-ub 486269 ATLIYVDkENGEPGT Securin protein degradation 11179223 1 1 0 required for sister chromatid separation +CD33 CD33 Cell adhesion; Membrane protein, integral P20138 945 19q13.41 human Y340-p 450952 EMDEELHyASLNFHG molecular association, regulation SHP-2(INDUCES); SHP-1(INDUCES) 10206955; 10887109 2 0 0 While tyrosine phosphorylation of CD33 was shown to induce its interaction in cells with SHP-1 and SHP-2, the specific contribution of Y340 phosphorylation to these interactions was based on in vitro binding experiments. +PPP5C PPP5C EC 3.1.3.16; PHOSPHATASE; Protein phosphatase, Ser/Thr (non-receptor) P53041 5536 19q13.32 human T362-p 344893200 LFSEDGVtLDDIRKI Metallophos enzymatic activity, induced cell growth, induced; apoptosis, inhibited 29141220 1 1 0 +Smad3 SMAD3 DNA-binding; Nuclear receptor co-regulator; Transcription factor Q8BUN5 17127 9|9 C mouse S425-p 448336 SIRCSSVs_______ molecular association, regulation; intracellular localization carcinogenesis, induced; cell growth, induced; cell motility, induced; cell growth, inhibited; cell differentiation, induced; transcription, induced SMAD4(INDUCES) DNA(INDUCES) 30042129; 32122971; 34799661; 37350664 41 0 5 +Nfkbia IkB-alpha DNA-binding; Inhibitor Q9Z1E3 18035 12|12 C1 mouse S36-p 448204 RHDSGLDsMKDEEYE protein degradation 10497169; 22633953 99 2 6 +NPHP1 NPHP1 Cell adhesion O15259 4867 2q13 human Y349-p 18449510 GNQFRANyFLQPELM molecular association, regulation; intracellular localization PACS-1(INDUCES) 21357692 1 0 0 +Axin1 axin 1 Adaptor/scaffold; Tumor suppressor O70239 79257 10q12 rat S321-p 2226507 PATSANDsEQQSLSS cytoskeletal reorganization 22933777 1 0 0 Phosphorylation regulates responsive to Sema3A induced growth cone collapse. +FYB1 SLAP-130 Adaptor/scaffold O15117 2533 5p13.1 human Y559-p 15149800 GRTARGSyGYIKTTA SH3_2 cell motility, altered; cell adhesion, altered 20661443 3 2 13 promotes adhesion to fibronectin; promotes cell migration +TNNI3 TNNI3 Actin-binding; Motility/polarity/chemotaxis; Motor P19429 7137 19q13.42 human S39-p 3146608 EPHAKKKsKISASRK molecular association, regulation TNNC1(DISRUPTS) 11121119 1 0 0 +NUPR1 NUPR1 Apoptosis; Cell cycle regulation; Cell development/differentiation O60356 26471 16p11.2 human K65-ac 465461 SPGGHERkLVTKLQN Phospho_p8 intracellular localization 16294328 1 0 0 regulates nuclear transport +KCNB1 Kv2.1 Channel, cation; Channel, ligand-gated; Channel, potassium; Membrane protein, integral; Membrane protein, multi-pass Q14721 3745 20q13.13 human S800-p 473567 EKNHFESsPLPTSPK activity, induced; intracellular localization; phosphorylation apoptosis, induced 19622611; 23857585; 26115091 5 3 0 induces phosphorylation at Y128 and membrane insertion of the channel; increased channel activity +MAPK11 P38B EC 2.7.11.24; KINASE; Kinase, protein; Protein kinase, CMGC; Protein kinase, Ser/Thr (non-receptor) Q15759 5600 22q13.33 human T180-p 15405068 RQADEEMtGYVATRW Pkinase enzymatic activity, induced 26976637 2 2 57 +NHERF1 NHERF Adaptor/scaffold; Motility/polarity/chemotaxis O14745 9368 17q25.1 human S162-p 450312 CTMKKGPsGYGFNLH PDZ molecular association, regulation CFTR(DISRUPTS) 12881487 3 9 1 +ABL1 Abl EC 2.7.10.2; KINASE; Kinase, protein; Oncoprotein; Protein kinase, TK; Protein kinase, tyrosine (non-receptor) P00519 25 9q34.12 human S446-p 450296 PYPGIDLsQVYELLE PK_Tyr_Ser-Thr enzymatic activity, induced 9168116 2 0 0 +Stxbp3 STXBP3 Vesicle Q60770 20912 3|3 F3 mouse Y218-p 463817 VEKKLEDyYKIDEKG Sec1 molecular association, regulation STX4(DISRUPTS) 23937695 2 0 0 2-deoxy-glucose uptake in adipocytes +RPS6KA1 p90RSK EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, AGC; Protein kinase, Ser/Thr (non-receptor); Translation Q15418 6195 1p36.11 human K421-sm 1881518210 FSDGYVVkETIGVGS molecular association, regulation; phosphorylation EIF4B(INDUCES) 34871326 1 0 0 SUMO-SIM interaction contributes to RSK1-eIF4B association; sites incudinge IF4B (Ser 422 and Ser 425, 29.91 fold), SETD1A (Ser 915 and Ser 916, 25.76 fold), LMNA (Ser 404 and Ser 406, 16.42 fold), ZNF 217 (Ser 975, 13.27 fold); SUMOylation is required for is required for replication and virus production of KSHV; affect eIF4B phosphorylation by RSK1 in vitro; SUMOylation affects the phosphorylation levels of its substrates +PRKAA2 AMPKA2 Autophagy; EC 2.7.11.1; EC 2.7.11.27; EC 2.7.11.31; KINASE; Kinase, protein; Protein kinase, CAMK; Protein kinase, Ser/Thr (non-receptor) P54646 5563 1p32.2 human K470-ub 15489433 RSYLLDFkSIDDEVV AdenylateSensor enzymatic activity, inhibited 31996460 1 1 1 +NR4A2 NR4A2 DNA-binding; Nuclear receptor P43354 4929 2q24.1 human T132-p 487426 SSPPTPTtPGFQVQH transcription, induced 17681692 2 0 0 +DNMT1 DNMT1 Amino Acid Metabolism - cysteine and methionine; Cell development/differentiation; EC 2.1.1.37; METHYLTRANSFERASE; Methyltransferase; Methyltransferase, DNA; Transcription regulation P26358 1786 19p13.2 human K957-ac 25171005 IKLSSPVkRPRKEPV BAH cell cycle regulation 21947282 1 1 0 +Myod1 MyoD DNA-binding; RNA splicing; Transcription factor P10085 17927 7 B3|7 30.03 cM mouse K99-ac 458968 RCLLWACkACKRKTT Basic activity, induced transcription, induced 10944526 3 1 0 +PGAM1 PGAM1 Carbohydrate Metabolism - glycolysis and gluconeogenesis; EC 3.1.3.13; EC 5.4.2.11; EC 5.4.2.4; Isomerase; Phosphatase (non-protein) P18669 5223 10q24.1 human S23-p 455496 WNLENRFsGWYDADL His_Phos_1 enzymatic activity, inhibited 12189148 1 17 14 +Bckdha BCKDH E1-alpha Amino Acid Metabolism - valine, leucine and isoleucine degradation; EC 1.2.4.4; Lyase; Mitochondrial; Oxidoreductase P11960 25244 1q21 rat S343-p 451657 DDSSAYRsVDEVNYW E1_dh enzymatic activity, inhibited 3947057 3 70 31 +Lats1 LATS1 EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, AGC; Protein kinase, Ser/Thr (non-receptor); Tumor suppressor F1M2K4 308265 1p13 rat T1079-p 457595 EHAFYEFtFRRFFDD phosphorylation 33568044 34 1 0 +FBXW7 FBXW7 Motility/polarity/chemotaxis; Nucleolus; UBIQUITIN LIGASE; Ubiquitin conjugating system; Ubiquitin ligase Q969H0 55294 4q31.3 human K412-ub 573780018 VWSAVTGkCLRTLVG WD40 protein degradation; molecular association, regulation TRIP12(INDUCES) 31186535; 33824312 2 2 0 +FLOT1 FLOT1 Adaptor/scaffold O75955 10211 6p21.33 human Y149-p 35494101 MGISVVSyTLKDIHD Band_7 molecular association, regulation SDHB(INDUCES) 24983503 1 0 0 decreased ROS productioned compared to Y56F and Y149F mutants +DAZAP1 DAZAP1 Motility/polarity/chemotaxis; RNA-binding Q96EP5 26528 19p13.3 human T315-p 467205 GVPPPPAtPGAAPLA molecular association, regulation DAZ1(DISRUPTS) 16848763 1 0 0 +CREB1 CREB DNA-binding; Transcription factor P16220 1385 2q33.3 human S119-p 448228 EILSRRPsYRKILND pKID activity, induced; molecular association, regulation; phosphorylation cell cycle regulation; carcinogenesis, induced; cell motility, induced; signaling pathway regulation; cell differentiation, altered; cell growth, induced; cell motility, altered; transcription, inhibited; cell differentiation, inhibited; carcinogenesis, inhibited; cell growth, inhibited; transcription, induced; transcription, altered; neural plasticity; DNA repair, induced; cell differentiation, induced; apoptosis, inhibited; translation, inhibited Myb(INDUCES); Nur77(INDUCES); CBP(INDUCES); MEIS1(INDUCES); p300(INDUCES); RGS13(INDUCES); TORC2(NOT_REPORTED); SOX9(INDUCES) DNA(INDUCES) 10558990; 12196545; 12660819; 14536081; 15033181; 15073328; 15073527; 15319449; 15454081; 15753290; 16301994; 16684769; 17389598; 17426037; 17429437; 18070920; 18775326; 19113914; 19651774; 20089855; 20541704; 20573984; 21422248; 23461423; 25404345; 27095572; 27191986; 29989005; 33846571; 34342229; 34411141; 34437633; 35378127; 35615594; 35901086; 36272644; 36459375; 36646789; 36773293; 7876182; 8552098; 8887554 311 5 61 +Mapkapk5 MAPKAPK5 EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, CAMK; Protein kinase, Ser/Thr (non-receptor); Tumor suppressor O54992 17165 5|5 F mouse T182-p 450093 VDQGDLMtPQFTPYY Pkinase acetylation; intracellular localization; phosphorylation; enzymatic activity, induced 12242275; 21336308; 23685072 6 10 94 increases acetylation MAPKAPK5-K364; induces phosphorylation of RHEB +IRF3 IRF3 DNA-binding; Transcription factor Q14653 3661 19q13.33 human T390-p 14665000 GASSLENtVDLHISN molecular association, regulation; phosphorylation CBP(INDUCES) 20511230 1 1 0 stimulates phosphorylation of S396 +PLCG1 PLCG1 Carbohydrate Metabolism - inositol phosphate; EC 3.1.4.11; Motility/polarity/chemotaxis; Phospholipase P19174 5335 20q12 human Y771-p 448575 IGTAEPDyGALYEGR activity, inhibited signaling pathway regulation 12652307 16 41 552 +NFE2 NF-E2 Cytoskeletal; DNA-binding; Transcription factor Q16621 4778 12q13.13 human K241-ub 11489906 KIPFPTDkIVNLPVD bZIP_Maf protein degradation; ubiquitination transcription, inhibited 19966288 1 0 1 +Sipa1l1 SIPA1L1 GAP; GAP, Ras O35412 246212 6q24 rat S1344-p 26348503 LQGTSADsGIDTASY protein degradation; molecular association, regulation; ubiquitination BTRC(INDUCES) 18723513 1 1 0 +PRKAA2 AMPKA2 Autophagy; EC 2.7.11.1; EC 2.7.11.27; EC 2.7.11.31; KINASE; Kinase, protein; Protein kinase, CAMK; Protein kinase, Ser/Thr (non-receptor) Q28948 397504 pig T172-p 448026 SDGEFLRtSCGSPNY Pkinase signaling pathway regulation 23799098 220 13 33 simvastatin-induced signaling for the closure of K-ATP channel +SEPTIN7 SEPT7 Cell cycle regulation; Cytoskeletal; Hydrolase Q16181 989 7p14.2 human T198-p 56658862 PLIAKADtLTPEECQ Septin molecular association, regulation cytoskeletal reorganization SEPT7(DISRUPTS) 33572403 1 2 0 inhibits ciliogenesis and septin filament formation +YBX1 YB-1 RNA processing; RNA splicing; RNA-binding; Transcription factor P67809 4904 1p34.2 human K81-ac 11322087 FINRNDTkEDVFVHQ CSD translation, inhibited 31668005 1 4 0 MS275 inhibits translation, and inhibits sarcoma metastasis in vivo, but mutant K81A rescues metastatic phenotype, blocks YB- 1-mediated pro-metastatic activity in sarcoma cells +PKP1 plakophilin 1 Cell adhesion; Motility/polarity/chemotaxis Q13835 5317 1q32.1 human S185-p 15405312 KTTQNRYsFYSTCSG activity, induced; protein stabilization cell motility, induced; cell growth, induced; translation, induced; cell adhesion, inhibited 23444369 1 4 76 +Tgs1 PIMT EC 2.1.1.-; METHYLTRANSFERASE; Methyltransferase; Nuclear receptor co-regulator; RNA processing P85107 312947 5q12 rat S295-p 3636737 DGTTLSSsPNTAEDE transcription, induced; transcription, inhibited 26468734 2 3 2 HDAC5 expression; inhibition of glucose uptake, attenuates GLUT4 and MEF2A expression +PTH1R PTHR GPCR, family 2; Membrane protein, integral; Membrane protein, multi-pass; Receptor, GPCR Q03431 5745 3p21.31 human T392-p 801662703 LATKLREtNAGRCDT 7tm_2 molecular association, regulation; ubiquitination ARRB1(INDUCES) 29444827 1 1 0 abrogation of phosphorylation at positions T387and T392 dramatically decreased PTHR ubiquitination +MORC3 MORC3 Cell cycle regulation; RNA-binding Q14149 23515 21q22.12 human K597-sm 14988616 VDHDIDMkSEQSHVE molecular association, regulation PML(INDUCES) 20501696 1 2 0 +DNMT1 DNMT1 Amino Acid Metabolism - cysteine and methionine; Cell development/differentiation; EC 2.1.1.37; METHYLTRANSFERASE; Methyltransferase; Methyltransferase, DNA; Transcription regulation P26358 1786 19p13.2 human K1111-ac 466385 RSPGNKGkGKGKGKG cell cycle regulation; transcription, inhibited 21947282 1 4 0 +Pdha1 PDHA1 Amino Acid Metabolism - valine, leucine and isoleucine biosynthesis; Carbohydrate Metabolism - butanoate; Carbohydrate Metabolism - citrate (TCA) cycle; Carbohydrate Metabolism - glycolysis and gluconeogenesis; Carbohydrate Metabolism - pyruvate; EC 1.2.4.1; Mitochondrial; Oxidoreductase P35486 18597 X F4|X 73.95 cM mouse K336-ac 11324468 LASVEELkEIDVEVR E1_dh enzymatic activity, inhibited; phosphorylation 23835326 1 4 2 +Nyap2 NYAP2 Cell development/differentiation Q8BM65 241134 1|1 C5 mouse Y300-p 455105 DDQSEAVyEEMKYPI NYAP_N molecular association, regulation PIK3R1(INDUCES) 21946561 1 5 21 localization to the neuronal plasma membrane, interaction with WAVE complex +ACOX1 ACOX1 EC 1.3.3.6; Lipid Metabolism - alpha-linolenic acid; Lipid Metabolism - fatty acid; Lipid Metabolism - unsaturated fatty acid biosynthesis; Oxidoreductase Q15067 51 17q25.1 human S26-p 3196823 LTHILDGsPEKTRRR Acyl-CoA_ox_N protein stabilization; ubiquitination; phosphorylation; palmitoylation carcinogenesis, inhibited; cell growth, inhibited; transcription, altered 36878899 1 21 0 induces CTNNB1 palmitoylation, regulates phosphorylation of downstream proteins and the DUSP14-ACOX1-PA-?-catenin signaling pathway +MDM2 MDM2 EC 6.3.2.-; EC 6.3.2.19; Inhibitor; Ligase; NEDDYLATION LIGASE; Neddylation Ligase; Nucleolus; Oncoprotein; UBIQUITIN LIGASE; Ubiquitin conjugating system; Ubiquitin ligase Q00987 4193 12q15 human S262-p 454944 DSEDYSLsEEGQELS activity, induced 12167711 3 1 0 promotes p53 degradation +Cttn Cortactin Actin-binding; Cytoskeletal; Motility/polarity/chemotaxis Q60598 13043 7|7 F5 mouse T401-p 449245 QARAKKQtPPASPSP cell cycle regulation; cell motility, altered 18515860 2 95 117 +Olig2 OLIG2 Oncoprotein; Transcription factor Q9EQW6 50913 16 C3.3|16 52.6 cM mouse K112-sm 1869334001 ELQQLRLkINSRERK HLH molecular association, regulation cell cycle regulation; carcinogenesis, induced; apoptosis, inhibited; DNA repair, inhibited; transcription, inhibited HDAC1(INDUCES) DNA(INDUCES) 32483381 1 1 0 +BAP1 BAP1 DEUBIQUITINASE; EC 3.4.19.12; Protease; Tumor suppressor; Ubiquitin conjugating system; Ubiquitin-specific protease Q92560 8314 3p21.1 human T273-p 31012813 TQPELIQtHKSQESQ intracellular localization DNA repair, induced 24347639 1 1 0 +SMAD3 SMAD3 DNA-binding; Nuclear receptor co-regulator; Transcription factor P84022 4088 15q22.33 human K378-ac 466353 TIRMSFVkGWGAEYR MH2 activity, induced transcription, induced 16862174; 32305562 3 4 0 +SOS1 SOS1 Adaptor/scaffold; GEF; GEF, Ras; Motility/polarity/chemotaxis Q07889 6654 2p22.1 human S1193-p 451316 QPTSKAYsPRYSISD molecular association, regulation GRB2(DISRUPTS) 8816480 1 1 0 +MAPRE1 EB1 Cytoskeletal; Motility/polarity/chemotaxis Q15691 22919 20q11.21 human K220-ac 11319860 ERDFYFGkLRNIELI EB1 molecular association, regulation; protein conformation cell cycle regulation; cytoskeletal reorganization MTUS2(DISRUPTS); KIF2C(DISRUPTS) 23001180 1 2 0 intramoleclar interaction, negatively regulates EB1 binding with SxIP motif of cargo proteins +CBLC Cbl-c EC 6.3.2.-; Ligase; NEDDYLATION LIGASE; Neddylation Ligase; UBIQUITIN LIGASE; Ubiquitin conjugating system; Ubiquitin ligase Q9ULV8 23624 19q13.32 human Y341-p 14913506 SEEQLQLyWAMDSTF protein degradation; molecular association, regulation; phosphorylation; enzymatic activity, induced UBE2D2(DISRUPTS) 20525694; 24425877 2 0 0 Y341 phosphorylation increases Ret ubquitylation; in vitro +Pax3 PAX3 DNA-binding; Oncoprotein; Transcription factor P24610 18505 1 C4|1 39.79 cM mouse S201-p 18744500 ERASAPQsDEGSDID cell growth, induced; transcription, inhibited 27588498 4 2 0 +MAF1 MAF1 Transcription regulation Q9H063 84232 8q24.3 human K35-sm 31094506 RIESYSCkMAGDDKH Maf1 molecular association, regulation cell growth, inhibited; transcription, inhibited POLR3A(INDUCES) 23673667 1 0 0 +MYH9 MYH9 Actin-binding; Motility/polarity/chemotaxis; Motor P35579 4627 22q12.3 human S1803-p 2482303 EMEGTVKsKYKASIT Myosin_tail_1 intracellular localization cytoskeletal reorganization 18394644 1 1 1 +NFE2L2 NRF2 DNA-binding; Transcription factor Q16236 4780 2q31.2 human S374-p 35497700 GDTLLGLsDSEVEEL activity, induced; protein degradation; protein stabilization; molecular association, regulation; ubiquitination transcription, induced; transcription, inhibited; signaling pathway regulation BTRC(INDUCES); FBW1B(INDUCES) 31805502; 37627580 2 2 0 +Mefv pyrin Actin-binding Q9JJ26 54483 16 A1|16 2.18 cM mouse S205-p 455897 AQLRRNVsSAGRLQG molecular association, regulation; activity, inhibited 14-3-3 epsilon(INDUCES) 27482109 8 1 2 dephosphorylation triggers 14-3-3 dissociation, activation, formation of an oligomeric Pyrin inflammasome complex +PGR PR DNA-binding; Nuclear receptor; Transcription factor P06401 5241 11q22.1 human K388-sm 486289 QPPALKIkEEEEGAE Prog_receptor sumoylation; protein stabilization; intracellular localization; protein conformation; activity, inhibited cell differentiation, inhibited; transcription, induced; transcription, inhibited; cell growth, altered 12114521; 12529333; 17020914; 17053081; 17717077; 19211567; 19706513; 22439847 11 0 0 represses basal proliferation of breast cancer cells; SENP1 and SENP2 strongly enhanced the transcription of WT liganded PR. +EGFR EGFR EC 2.7.10.1; KINASE; Kinase, protein; Membrane protein, integral; Oncoprotein; Protein kinase, TK; Protein kinase, tyrosine (receptor) P00533 1956 7p11.2 human K960-ub 1065310 IDADSRPkFRELIIE PK_Tyr_Ser-Thr protein degradation 17940017 1 1 0 +CREB1 CREB DNA-binding; Transcription factor P16220 1385 2q33.3 human S97-p 451808 TIAESEDsQESVDSV molecular association, regulation; activity, inhibited; phosphorylation transcription, inhibited CBP(INDUCES) 15073328; 17209043 9 3 3 +Tnnt2 TNNT2 iso2 Motility/polarity/chemotaxis; Motor P50753-2 24837 13q13 rat T195-p 449038 GYIQKAQtERKSGKR Troponin protein conformation 24708997 6 0 0 T204E mutant blunts Ca2+ sensitivity, PKC phosphorylation of these residues can increase or decrease Ca2+ sensitivity and cardiac regulation +BRCA1 BRCA1 EC 6.3.2.-; Nuclear receptor co-regulator; Transcription, coactivator/corepressor; Tumor suppressor; UBIQUITIN LIGASE; Ubiquitin conjugating system; Ubiquitin ligase P38398 672 17q21.31 human S1457-p 450008 SEKAVLTsQKSSEYP molecular association, regulation cell cycle regulation; DNA repair, altered ATM(INDUCES) 10550055; 26320175 7 4 1 prolong mitosis and induce mitotic aberrations +N Nucleocapsid Protein P59595 1489678 SARSCoV1 S202-p 1868174951 SRNSTPGsSRGNSPA CoV_nucleocap molecular association, regulation Nucleocapsid Protein(INDUCES) 23717688 2 3 0 di-domain self-association +AURKA AurA EC 2.7.11.1; KINASE; Kinase, protein; Oncoprotein; Protein kinase, Other; Protein kinase, Ser/Thr (non-receptor) O14965 6790 20q13.2 human K143-ub 21129736 GRPLGKGkFGNVYLA Pkinase protein degradation; enzymatic activity, inhibited carcinogenesis, inhibited; cell growth, inhibited 34758762 1 6 0 +GRK7 GRK7 EC 2.7.11.14; EC 2.7.11.16; KINASE; Kinase, protein; Protein kinase, AGC; Protein kinase, Ser/Thr (non-receptor) Q8WTQ7 131890 3q23 human S23-p 456354 YLQARKPsDCDSKEL enzymatic activity, inhibited 15946941 1 0 0 reaction in vitro +Ctnnd2 CTNND2 Actin-binding; Motility/polarity/chemotaxis O35927 18163 15|15 B2 mouse T1078-p 2020381 RPYSSSRtPSISPVR protein degradation; ubiquitination 19706605 1 4 0 +FXYD1 PLM Cell surface; Channel, misc.; Membrane protein, integral O00168 5348 19q13.12 human S88-p 451425 RSSIRRLsTRRR___ activity, induced; molecular association, regulation; protein conformation; enzymatic activity, induced ATP1A1(DISRUPTS); PLM(INDUCES) 21220422; 21653224; 24105627; 26429909; 33635930 27 3 74 induces NKA activity; reverse PLM bindiing inhibition of Na,K-ATPase activity +Acaca ACC1 Carbohydrate Metabolism - propanoate; Carbohydrate Metabolism - pyruvate; EC 6.3.4.14; EC 6.4.1.2; Ligase; Lipid Metabolism - fatty acid biosynthesis P11497 60581 10q26 rat S29-p 448771 GSVSEDNsEDEISNL enzymatic activity, inhibited 2900140 1 77 3 +Apbb1ip RIAM Adaptor/scaffold; Motility/polarity/chemotaxis Q8R5A3 54519 2|2 A3 mouse Y267-p 1871479100 FLEKEERyAVFKNPQ activity, induced; intracellular localization cell adhesion, induced; signaling pathway regulation 33275877 1 0 0 induces integrin activation/ integrin signaling pathway +Hdac7 HDAC7 DEACETYLASE; Deacetylase; EC 3.5.1.98; Hydrolase Q8C2B3 56233 15|15 F1 mouse S479-p 452459 RPLSRTQsSPAAPVS molecular association, regulation 14-3-3 epsilon(DISRUPTS) 16956611 7 31 66 +EPHA2 EphA2 EC 2.7.10.1; KINASE; Kinase, protein; Membrane protein, integral; Protein kinase, TK; Protein kinase, tyrosine (receptor) P29317 1969 1p36.13 human Y960-p 461994 GHQKRIAySLLGLKD SAM_1 molecular association, regulation SHIP-2(INDUCES) 24825902 2 12 57 +PA2G4 Ebp1 Nuclear receptor co-regulator; Nucleolus; Transcription, coactivator/corepressor Q9UQ80 5036 12q13.2 human S360-p 478276 ELKALLQsSASRKTQ protein stabilization; molecular association, regulation; intracellular localization apoptosis, inhibited; transcription, induced; cell growth, altered TIF1A(INDUCES); NPM1(INDUCES); Akt1(INDUCES) 16642037; 17316401; 17951246; 25691158 5 2 1 enhanced rRNA synthesis; in cells stimulated with EGF; sumoylation of NPM K263 and K230 is required for the association between NPM and PA2G4 and distribution of PA2G4 in cells; detected in mitotic cells, but not in interphase cells; phosphorylation of this site protects PA2G4 (aka Ebp1) from apoptotic degradation and promotes cell survival +GTF2I GTF2I iso2 DNA-binding; Transcription, coactivator/corepressor P78347-2 2969 7q11.23 human Y611-p 448253 KPELVISyLPPGMAS cell cycle regulation; transcription, induced; transcription, altered 11934902; 16314517 2 0 0 +TRPC3 TRPC3 Channel, cation; Membrane protein, integral; Membrane protein, multi-pass Q13507 7222 4q27 human T646-p 20612407 LQISLGRtVKDIFKF Ion_trans molecular association, regulation transcription, induced; signaling pathway regulation PPP3CA(INDUCES) 21653882 1 0 0 phosphorylation of TPRC3 converts it into a transcriptionally active mode and dephosphorylation converts it into trancriptionally silent mode. +Slc1a2 GLT1 Membrane protein, integral; Membrane protein, multi-pass; Transporter; Transporter, SLC family P31596 29482 3q32 rat K550-ub 4667700 SVVIDECkVTLAANG receptor internalization, induced; protein degradation 18805448 2 0 0 +CTNNB1 CTNNB1 Actin-binding; Cell adhesion; Motility/polarity/chemotaxis; Nuclear receptor co-regulator; Oncoprotein; Transcription factor P35222 1499 3p22.1 human K19-ac 5013900 MAMEPDRkAAVSHWQ protein stabilization; intracellular localization carcinogenesis, inhibited; cell motility, induced; transcription, induced 18987336 3 0 0 +Grin2b NMDAR2B Channel, calcium; Channel, ligand-gated; Membrane protein, integral; Membrane protein, multi-pass Q01097 14812 6 G1|6 66.38 cM mouse S1116-p 3984496 YRRRPPRsPDHKRYF NMDAR2_C receptor internalization, induced CDK5(INDUCES) 24607229 1 2 2 disruption of interaction facilitates synaptic transmission and ehancement of fear memory +PCNA PCNA Cell cycle regulation; DNA replication P12004 5111 20p12.3 human Y133-p 231166700 LGIPEQEySCVVKMP PCNA_C ubiquitination cell cycle regulation 28924044 1 1 0 +ABL1 Abl iso2 EC 2.7.10.2; KINASE; Kinase, protein; Oncoprotein; Protein kinase, TK; Protein kinase, tyrosine (non-receptor) P00519-2 25 9q34.12 human T197-p 12121095 VYHYRINtASDGKLY SH2 enzymatic activity, inhibited apoptosis, inhibited 23852372 1 0 0 +NFKB1 NFkB-p105 DNA-binding; Transcription factor P19838 4790 4q24 human S20-p 18751700 QMFHLDPsLTHTIFN molecular association, regulation DNA(INDUCES) 20966071 1 0 0 +MAPT Tau iso8 ACETYLTRANSFERASE; Acetyltransferase; Cytoskeletal P10636-8 4137 17q21.31 human T217-p 449078 SRTPSLPtPPTREPK O-GlcNAc glycosylation; molecular association, regulation; intracellular localization cytoskeletal reorganization Tau iso8(INDUCES) 15190058; 16987243; 19451179; 20550628 41 34 6 hyperphosphorylation of this site decreases O-GlcNAcylation of tau ; polymerized into filaments when 4?6 mol of phosphate per mol of tau were incorporated; decreases rate of microtubule assembly; Phosphotylated sites found in the somato-dendritic campartment but not in the axon, where tau was not phosphorylated (T205 and T217), or not simultaneously phosphorylated (T231 and 235). +Pard3 PAR3-alpha Adaptor/scaffold; Motility/polarity/chemotaxis Q9Z340 81918 19q12 rat S889-p 455653 LGLKKSSsLESLQTA molecular association, regulation; intracellular localization cytoskeletal reorganization 14-3-3 zeta(INDUCES) 33093242 4 1 0 regulation of PAR3 oligomerization, regulation of tight junction formations and morphological changes in epithelial cell layer +Znf622 ZNF622 Transcription factor Q91VY9 52521 15 B1|15 9.71 cM mouse T251-p 63052801 PLGAIPItDCLFCSH zf-C2H2_2 protein stabilization; molecular association, regulation; enzymatic activity, induced apoptosis, induced; transcription, induced; signaling pathway regulation 28195154 1 0 0 +SMARCAL1 SMARCAL1 EC 3.6.1.-; EC 3.6.4.-; Helicase Q9NZC9 50485 2q35 human S129-p 29606710 ISPPLAQsPPEVPKQ protein degradation 30996091 1 12 0 +AR AR DNA-binding; Nuclear receptor; Transcription factor P10275 367 Xq12 human S579-p 4275600 YGALTCGsCKVFFKR zf-C4 activity, induced; protein degradation; molecular association, regulation; ubiquitination; intracellular localization carcinogenesis, inhibited; transcription, induced Ku70(DISRUPTS); Ku80(DISRUPTS); MDM2(INDUCES) 18511414; 23132866; 27902483 3 0 0 nuclear translocation inhibited +PIGL PIGL DEACETYLASE; Deacetylase; EC 3.5.1.89; Glycan Metabolism - glycosylphosphatidylinositol (GPI)-anchor biosynthesis; Membrane protein, integral Q9Y2B2 9487 17p11.2 human Y81-p 1881980200 LCFSAGNyYNQGETR molecular association, regulation; intracellular localization carcinogenesis, induced KPNB1(DISRUPTS); Myc(DISRUPTS); KPNA2(DISRUPTS) 37280393 1 0 0 +Htt Huntingtin Cytoskeletal P42859 15194 5 B2|5 17.92 cM mouse S1179-p 465620 EQASTPMsPKKVGEA intracellular localization cell differentiation, inhibited; exocytosis, inhibited; cell growth, inhibited; apoptosis, inhibited; transcription, inhibited 17611284; 23678106; 32640230 4 29 2 +EZH2 EZH2 EC 2.1.1.43; METHYLTRANSFERASE; Methyltransferase; Methyltransferase, protein lysine Q15910 2146 7q36.1 human S21-p 457606 CWRKRVKsEYMRLRQ molecular association, regulation; intracellular localization; enzymatic activity, inhibited; enzymatic activity, induced carcinogenesis, induced; DNA repair, induced; cell growth, induced; apoptosis, inhibited; transcription, induced H3(DISRUPTS); NFAT2(INDUCES) 16224021; 26517694; 34230470; 34943970; 35031563 9 1 1 +Map3k8 Cot EC 2.7.11.25; KINASE; Kinase, protein; Oncoprotein; Protein kinase, STE; Protein kinase, Ser/Thr (non-receptor) Q07174 26410 18 A1|18 2.73 cM mouse T290-p 455276 LPKDLRGtEIYMSPE Pkinase intracellular localization; phosphorylation; enzymatic activity, induced transcription, induced; signaling pathway regulation 15778223; 33488582 6 0 0 ; induces phosphorylation of IRF3, thus inducing IRF3/IFN-beta signaling +LAT LAT Adaptor/scaffold; Membrane protein, integral O43561 27040 16p11.2 human Y200-p 448004 SMESIDDyVNVPESG LAT activity, induced; molecular association, regulation cytoskeletal reorganization; transcription, induced; transcription, altered SLP76(INDUCES); GRB2(INDUCES); PLCG1(INDUCES); GADS(INDUCES) 10811803; 11046020; 20460647; 33929486 24 1 17 NF-AT mediated transcription; Does not regulate integrin mediated adhesion.; association of LAT-rich vesicles with surface clusters of SLP76 +BCL2 Bcl-2 Apoptosis; Autophagy; Membrane protein, integral; Oncoprotein P10415 596 18q21.33 human S70-p 448395 RDPVARTsPLQTPAA molecular association, regulation; intracellular localization; activity, inhibited cell cycle regulation; carcinogenesis, induced; apoptosis, altered; autophagy, induced; apoptosis, induced; apoptosis, inhibited; cell growth, altered BAX(INDUCES); beclin 1(DISRUPTS); BAX(DISRUPTS); p53(DISRUPTS) 10567572; 11077443; 12101183; 12421819; 15210690; 15703383; 16738310; 17097560; 17377139; 18570871; 18794113; 19029119; 21726807; 21778226; 28237688; 31959066; 34280220; 35013120; 36455198 49 1 0 +Gata1 GATA1 DNA-binding; Transcription factor P17679 14460 X A1.1|X 3.59 cM mouse K308-ac 459195 GIQTRNRkASGKGKK protein degradation; acetylation; ubiquitination; phosphorylation DNA(INDUCES) 16858405 2 1 0 Phosphorylation and acetylation cause the degradation of acetylated GATA-1; acetylation of GATA-1 causes ubiquitination; DNA binding is required for MAPK-dependent phosphorylation +FOXO1 FOXO1A DNA-binding; Nuclear receptor co-regulator; Oncoprotein; Transcription factor Q12778 2308 13q14.11 human S234-p 4258804 QNEGTGKsSWWMLNP Forkhead molecular association, regulation DNA(DISRUPTS) 18786403 1 1 0 +NCOA3 SRC-3 ACETYLTRANSFERASE; Acetyltransferase; EC 2.3.1.48; Motility/polarity/chemotaxis; Nuclear receptor co-regulator; Transcription, coactivator/corepressor Q9Y6Q9 8202 20q13.12 human S867-p 454107 SPVSVGSsPPVKNIS molecular association, regulation carcinogenesis, induced; cell growth, induced; transcription, induced ER-alpha(DISRUPTS) 15383283; 16760465; 33542078 5 12 0 +RUNX3 AML2 DNA-binding; Transcription factor Q13761 864 1p36.11 human K94-ub 11998600 KTLPVAFkVVALGDV Runt protein degradation; intracellular localization transcription, inhibited 19808967 1 0 0 nuclear export +Ahcyl1 AHCYL1 Amino Acid Metabolism - cysteine and methionine; EC 3.3.1.1; Hydrolase; Other Amino Acids Metabolism - selenoamino acid Q80SW1 229709 3 F2.3|3 46.83 cM mouse S80-p 25729419 DSYSSAAsYTDSSDD molecular association, regulation PIP5K1A(INDUCES) 26509711 1 0 3 +Rps6ka5 MSK1 EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, AGC; Protein kinase, Ser/Thr (non-receptor) Q8C050 73086 12|12 E mouse T764-p 471413 LSSNPLMtPDILGSS phosphorylation; enzymatic activity, induced 17117922 1 4 16 T645 phosphorylation +TELO2 TELO2 Adaptor/scaffold Q9Y4R8 9894 16p13.3 human S491-p 15668106 GSDSDLDsDDEFVPY molecular association, regulation; intracellular localization; enzymatic activity, induced DNAPK(INDUCES); ATM(INDUCES); PIH1D1(INDUCES) 20864032; 24656813; 24657168 3 2 0 increase stablization of DNA-PKs, ATM and PIKKs; this interaction (as a part of R2TP/prefoldin-like complex) is important for mTor and Smg1 stability; Phosphopeptide binding activity of PIH1D1 is important for the function of R2TP complex. +SF3B1 SF3B1 RNA splicing; RNA-binding; Spliceosome O75533 23451 2q33.1 human T244-p 455541 GRAKGSEtPGATPGS molecular association, regulation NIPP-1(INDUCES) 12105215 1 36 6 +Atr ATR EC 2.7.11.1; KINASE; Kinase, protein; Membrane protein, integral; Protein kinase, Ser/Thr (non-receptor); Protein kinase, atypical Q9JKK8 245000 9|9 E3.3 mouse S431-p 456320 SGNNDEVsPKRRKLS enzymatic activity, induced 18606816 25 13 1 +MPV17 MPV17 Membrane protein, integral; Membrane protein, multi-pass; Mitochondrial P39210 4358 2p23.3 human T80-p 40586901 LDRFIPGtTKVDALK protein conformation 25861990 1 0 0 may influence channel voltage-dependant gating under oxidizing/reducing conditions +Dab1 DAB1 iso2 Adaptor/scaffold P97318-2 13131 4 C6|4 47.79 cM mouse S550-p 479424 EPSGDNIsPQDGS__ phosphorylation 16529723 1 0 0 inhibits tyrosine phosphorylation +Itgb2 ITGB2 Cell adhesion; Cell surface; Membrane protein, integral; Motility/polarity/chemotaxis; Receptor, misc. P11835 16414 10 C1|10 39.72 cM mouse T760-p 448533 NPLFKSAtTTVMNPK Integrin_b_cyt cell motility, induced; cell adhesion, induced 23823319 8 2 3 T-cell homing to lymphocytes +STAT1 STAT1 DNA-binding; Transcription factor P42224 6772 2q32.2 human K410-ac 459198 EFRHLQLkEQKNAGT STAT_bind molecular association, regulation; intracellular localization; phosphorylation cell growth, inhibited; apoptosis, induced; transcription, induced; signaling pathway regulation; transcription, inhibited PPAR-gamma(INDUCES); NFkB-p65(INDUCES) DNA(INDUCES); DNA(DISRUPTS) 16481475; 19171783; 21576370; 26504087 4 1 1 induces dephosphorylation STAT1, regulates STAT1-associated cytokine signaling; CD36 expression; association with NFkB inhibits NFkB-DNA binding ; inhibition of transcription and nuclear import is a result of its disruption of DNA binding, and nuclear import signal. and not acetylation +PLD2 PLD2 EC 3.1.4.4; Lipid Metabolism - ether lipid; Lipid Metabolism - glycerophospholipid; Motility/polarity/chemotaxis; Phospholipase O14939 5338 17p13.2 human S134-p 456492 ARFAVAYsPARDAGN PX enzymatic activity, induced 18625302 2 6 0 stimulates EGF-dependent insulin secretion in pancreatic beta-cells +JUN Jun Oncoprotein; Transcription factor P05412 3725 1p32.1 human K271-ac 458867 IAASKCRkRKLERIA bZIP_1 molecular association, regulation carcinogenesis, induced; transcription, induced; signaling pathway regulation; transcription, inhibited DNA(INDUCES) 11689449; 16214953; 27956703; 36010303 5 0 0 increases the transcriptional activity of targeted genes, acetylated high expression significantly increased MMP-9 mRNA levels; AP-1 signaling pathway +ILK ILK EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, Ser/Thr (non-receptor); Protein kinase, TKL Q13418 3611 11p15.4 human S343-p 448495 SMADVKFsFQCPGRM PK_Tyr_Ser-Thr molecular association, regulation Akt1(INDUCES) 11313365 4 0 1 +TFAP2C AP-2 gamma DNA-binding; Motility/polarity/chemotaxis; Transcription factor Q92754 7022 20q13.31 human K10-sm 2407420 WKITDNVkYEEDCED transcription, inhibited 12072434 1 0 0 +NEK3 NEK3 EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, Other; Protein kinase, Ser/Thr (non-receptor) P51956 4752 13q14.3 human T165-p 57829902 FACTYVGtPYYVPPE Pkinase enzymatic activity, induced cell motility, induced; cell adhesion, altered 27489110 1 0 0 focal adhesion maturation +ATP2A2 SERCA2 Cell adhesion; EC 3.6.3.8; Endoplasmic reticulum; Hydrolase; Membrane protein, integral; Membrane protein, multi-pass; Transporter; Transporter, ion channel P16615 488 12q24.11 human K541-ub 486899 VPMTSGVkQKIMSVI protein degradation 35611810 1 3 2 SIGMAR1 interacts with Q615 site and mediates SERCA2 degradation +NOVA2 NOVA2 Q9UNW9 4858 19q13.32 human S194-p 1869341903 EQVHKAVsAIVQKVQ KH_1 intracellular localization 32492405 1 1 0 Phosphorylated NOVA2 translocates to cytosol leading to reduced E29 inclusion in BK channel and thereby inhibiting BK channel activity. +MAPKAPK2 MAPKAPK2 EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, CAMK; Protein kinase, Ser/Thr (non-receptor) P49137 9261 1q32.1 human T222-p 448269 TSHNSLTtPCYTPYY Pkinase activity, induced; phosphorylation 23740979; 8846784 14 3 42 +FAAP20 FAAP20 iso2 Q6NZ36 199990 1p36.33 human K152-ub 41486807 RSCPMCQkEFAPRLT UBZ_FAAP20 protein degradation; ubiquitination FBXW7(INDUCES) 27232758 1 2 0 +YAP1 YAP1 iso2 Oncoprotein; Transcription, coactivator/corepressor P46937-2 10413 11q22.1 human S387-p 3190675 ESTDSGLsMSSYSVP ubiquitination BTRC(INDUCES) 20048001 2 3 0 +Carm1 CARM1 EC 2.1.1.125; METHYLTRANSFERASE; Methyltransferase; Methyltransferase, protein arginine; Nuclear receptor co-regulator Q9WVG6 59035 9|9 A3 mouse K228-ub 22241798 QHAEVLVkSNNLTDR PrmA protein degradation 34480022 1 3 0 Targeting CARM1 attenuates severity of cellular injury in an experimental mouse lung in?ammation model. +Ppp2ca PPP2CA EC 3.1.3.16; Motility/polarity/chemotaxis; PHOSPHATASE; Protein phosphatase, Ser/Thr (non-receptor) P63330 19052 11|11 B1.3 mouse Y307-p 448571 VTRRTPDyFL_____ enzymatic activity, inhibited; activity, inhibited; phosphorylation; enzymatic activity, induced cytoskeletal reorganization; cell motility, inhibited 18208556; 22729898; 23579329; 23590304; 23630944; 25002528; 25394676; 27183589; 35331293 73 1 0 astrocyte migration (motility) inhibited; induces eNOS dephosphorylation; AB accumulation ; activation of P38 MAPK abolishes astrocyte migration; PP2A activity inhibited +DDX3X DDX3 Cell cycle regulation; EC 3.6.4.13; Helicase; RNA-binding; Spliceosome; Translation initiation O00571 1654 Xp11.4 human K55-ub 22243166 ATKGFYDkDSSGWSS transcription, induced 34445801 1 6 0 RIG-I-mediated IFNB1 gene induction; in?uenza A virus non-structural protein 1 (NS1) disrupts the TRIM25-DDX3X interaction +PELP1 PELP1 Nuclear receptor co-regulator; Transcription, coactivator/corepressor Q8IZL8 27043 17p13.2 human S991-p 15334104 PALPPPEsPPKVQPE cell cycle regulation; carcinogenesis, altered; transcription, altered 20807815 1 1 0 +CHEK2 Chk2 EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, CAMK; Protein kinase, Ser/Thr (non-receptor); Tumor suppressor O96017 11200 22q12.1 human S140-p 6339800 TDKYRTYsKKHFRIF FHA protein conformation; enzymatic activity, induced PLK1(INDUCES) 18948271 1 0 0 dimerization and activation of of Chk2 +EEF2K EEF2K EC 2.7.11.20; KINASE; Kinase, protein; Protein kinase, Ser/Thr (non-receptor); Protein kinase, atypical; Translation O00418 29904 16p12.2 human T348-p 3150902 KLLQSAKtILRGTEE protein degradation; protein conformation; phosphorylation; enzymatic activity, induced 22216903; 24732796; 25012662; 25670349; 27956550; 29800565; 33890716 10 20 6 +PRC1 PRC1 Cell cycle regulation; Cytoskeletal; Microtubule-binding; Motility/polarity/chemotaxis O43663 9055 15q26.1 human Y464-p 474466 QTETEMLyGSAPRTP MAP65_ASE1 intracellular localization 33510346 1 8 47 +PDE8A PDE8A EC 3.1.4.53; Nucleotide Metabolism - purine; Phosphodiesterase O60658 5151 15q25.3 human S359-p 18261095 HKDRRKGsLDVKAVA enzymatic activity, induced 22673573 1 4 0 +TICRR TICRR Cell cycle regulation; DNA replication Q7Z2Z1 90381 15q26.1 human S1001-p 4752817 DIGVVEEsPEKGDEI Treslin_N molecular association, regulation; phosphorylation cell cycle regulation; signaling pathway regulation TOPBP1(INDUCES) 21646402; 21700459; 23696651; 25454945; 25737283; 35231445 6 16 0 It stimulates CHK1 phosphorylation by ATR in vitro and in vivo. It is involved in ATR-mediated checkpoint signaling.; DNA replication induced; shortens S phase, increases replication initiation +ZEB1 TCF8 C2H2-type zinc finger protein; DNA-binding; Motility/polarity/chemotaxis; Transcription, coactivator/corepressor P37275 6935 10p11.22 human K1108-ub 964549554 QASSLGQkVGESSEQ protein degradation 35342335 1 1 0 +SLX4 SLX4 DNA repair, damage; Deoxyribonuclease Q8IY92 84464 16p13.3 human T1571-p 1880104210 PQYSIMEtPVLKKEL molecular association, regulation; protein conformation MUS81(INDUCES) 36288699 1 1 0 +CDC25A CDC25A EC 3.1.3.48; Motility/polarity/chemotaxis; PHOSPHATASE; Protein phosphatase, dual-specificity P30304 993 3p21.31 human S320-p 1874397804 HQSLSLAsSPKGTIE M-inducer_phosp protein degradation; ubiquitination cell cycle regulation; apoptosis, inhibited 34363019 1 1 0 +RPL11 RPL11 Motility/polarity/chemotaxis; Nucleolus; Ribosomal; Translation P62913 6135 1p36.11 human K78-ne 12067610 HCTVRGAkAEEILEK Ribosomal_L5_C protein stabilization; intracellular localization 19713960 1 0 0 +MIP AQP0 Channel, misc.; Membrane protein, integral; Membrane protein, multi-pass; Transporter, aquaporin family P30301 4284 12q13.3 human S231-p 453399 FPRLKSIsERLSVLK molecular association, regulation Calmodulin(DISRUPTS) 18081321 2 2 0 +CAPZB CAPZB iso1 Actin-binding; Motility/polarity/chemotaxis P47756-1 832 1p36.13 human T186-p 14571038 TNKSGSGtMNLGGSL F_actin_cap_B cell motility, induced; cell adhesion, induced; cytoskeletal reorganization 32771000 1 3 1 +MRE11 MRE11A Cell cycle regulation; DNA repair, damage; DNA-binding; Deoxyribonuclease P49959 4361 11q21 human K339-ub 964527898 IQSFCLEkIEEMLEN Mre11_DNA_bind activity, induced; ubiquitination DNA repair, induced 36563124 1 2 0 MRE11A promotes its exonuclease activity +H4C1 H4 DNA-binding P62805 8359 6p22.2 human K91-ac 480248 MDVVYALkRQGRTLY CENP-T_C DNA repair, induced; transcription, induced 18985155; 23653357 4 5 253 +RIPK1 RIPK1 EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, Ser/Thr (non-receptor); Protein kinase, TKL Q13546 8737 6p25.2 human K377-ub 486338 NEPSLQSkLQDEANY protein degradation; molecular association, regulation; protein processing; enzymatic activity, inhibited; phosphorylation; enzymatic activity, induced carcinogenesis, induced; cell growth, induced; apoptosis, inhibited; transcription, induced; transcription, inhibited; signaling pathway regulation IKKB(INDUCES); TAK1(INDUCES); TAB2(INDUCES); FADD(INDUCES); IKKG(INDUCES) 16543241; 16603398; 21419663; 21613257; 23770847; 27270888 11 0 0 induces IKK-enzymatic activity and NF-kB-target gene transcription; promotes recruitment of RIPK downstream signaling components to the TNFR1 complex in lipid rafts leading to NFkB activation, In RIPK- cells apoptosis is induced. ; inhibits TLR3-induced NF-kB signaling ; promotes API2-MALT1-dependent lymphomagenesis via TNFR and antigen receptor-associated NF-kB signaling; induces RIPK1 cleavage by caspase-8; regulates antiapoptotic function of FAIM3 +Actn4 ACTN4 Cytoskeletal; Motility/polarity/chemotaxis P57780 60595 7|7 B1 mouse Y4-p 11498501 ____MVDyHAANQAY cytoskeletal reorganization 33532643 5 0 0 decreased binding to actin filaments has been observed after phosphorylation of this site +PYHIN1 PYHIN1 Tumor suppressor Q6K0P9 149628 1q23.1 human K110-ac 1881258604 PSKKTKQkEVYPATP intracellular localization 34156286 1 1 0 induces partial cytoplasmic localization +Atf3 ATF-3 Transcription factor Q60765 11910 1 H6|1 96.28 cM mouse K42-sm 31094511 ANLTPFVkEELRFAI protein stabilization; ubiquitination transcription, induced 26850942 3 1 0 inhibits ubiquitination +SMARCD3 SMARCD3 Nuclear receptor co-regulator; Transcription, coactivator/corepressor Q6STE5 6604 7q36.1 human S247-p 27422800 VKRPGDLsVRCTLLL molecular association, regulation; intracellular localization chromatin organization, altered; transcription, induced USF1(INDUCES) 23219531 1 1 0 +ELF4 ELF4 DNA-binding; Oncoprotein; Transcription factor Q99607 2000 Xq26.1 human S641-p 463812 SGSLLTRsPTPAPFS protein degradation transcription, induced; signaling pathway regulation 16581786; 21465527; 25081543 3 7 1 regulates MKK4/JNK pathway +Nr4a2 NR4A2 DNA-binding; Nuclear receptor Q06219 18227 2 C1.1|2 31.66 cM mouse T129-p 487425 YKPSSPPtPSTPSFQ intracellular localization 25752609 2 0 0 cytoplasmic translocation, required for H2O2-induced necrosis +YY1 YY1 C2H2-type zinc finger protein; Cell development/differentiation; Transcription factor P25490 7528 14q32.2 human S180-p 27276103 KKGGGKKsGKKSYLS molecular association, regulation DNA(INDUCES) 23226345 1 0 0 +CCND1 CCND1 Activator; Cell cycle regulation; Nuclear receptor co-regulator; Oncoprotein P24385 595 11q13.3 human T288-p 451435 VDLACTPtDVRDVDI protein degradation; intracellular localization 10766840; 17046823 5 0 0 +KEAP1 KEAP1 Endoplasmic reticulum; Motility/polarity/chemotaxis; Transcription regulation; UBIQUITIN LIGASE; Ubiquitin conjugating system Q14145 9817 19p13.2 human T277-p 15404187 AVRCHSLtPNFLQMQ BACK molecular association, regulation PIN1(INDUCES) 34918396 1 0 2 +ERBB4 HER4 EC 2.7.10.1; KINASE; Kinase, protein; Membrane protein, integral; Protein kinase, TK; Protein kinase, tyrosine (receptor) Q15303 2066 2q34 human K714-sm 1873286906 QAQLRILkETELKRV molecular association, regulation; intracellular localization; phosphorylation cell differentiation, induced; signaling pathway regulation Exportin-1(INDUCES) 28974580 1 0 0 nuclear accumulation regulated by Exportin-1-dependent nuclear export, increases autophosphorylation, required for the RIP-mediated nuclear signaling of ErbB4 ICD in mammary epithelial cells +PLCL1 PLCL1 Phospholipase Q15111 5334 2q33.1 human T246-p 467202 PRFMWLKtVFEAADV molecular association, regulation PPP1CA(INDUCES) 16854455 1 0 0 +Srsf1 SF2 RNA splicing; RNA-binding; Spliceosome NP_001103022 689890 10q26 rat S238-p 468705 SRGSPRYsPRHSRSR intracellular localization 18658135 1 39 17 inhibits tau exon 10 inclusion, and increases 3R-tau production +PDK1 PDHK1 EC 2.7.11.2; KINASE; Kinase, protein; Mitochondrial; Protein kinase, Ser/Thr (non-receptor); Protein kinase, atypical Q15118 5163 2q31.1 human T338-p 54390604 LFNYMYStAPRPRVE HATPase_c enzymatic activity, induced carcinogenesis, induced; cell growth, induced 26942675; 31578148 4 1 0 +Lat LAT Adaptor/scaffold; Membrane protein, integral O54957 16797 7|7 F3 mouse Y195-p 448005 SLDGSREyVNVSPEQ LAT molecular association, regulation; intracellular localization; phosphorylation cell adhesion, altered USP9X(INDUCES); Fyn(INDUCES) 15470052; 15699109; 17579183; 26936881 40 4 54 Localization of recruited PLCG2 to the membrane/cytoskeleton; proximity with TCR-associated ZAP70; Fyn may be involved in LAT phosphorylation. +CENPQ CENPQ Q7L2Z9 55166 6p12.3 human S50-p 18007851 KNHLKDLsSEGQTKH intracellular localization cell cycle regulation 25395579 1 8 0 regulation of chromosome congression mechanism +ITGB1 ITGB1 Cell adhesion; Cell surface; Membrane protein, integral; Motility/polarity/chemotaxis; Receptor, misc. P05556 3688 10p11.22 human K794-ac 11320212 VTTVVNPkYEGK___ Integrin_b_cyt acetylation cell adhesion, induced 32182705 1 4 0 acetylation promotes FN matrix assembly, integrin activation +ECD SGT1 Transcription, coactivator/corepressor O95905 11319 10q22.2 human S503-p 3178821 LGPRPNEsDSDDLDD SGT1 cell cycle regulation 26711270 1 7 0 +ETFB ETFB Mitochondrial; Oxidoreductase P38117 2109 19q13.41 human K203-m2 36974101 PNIMKAKkKKIEVIK ETF enzymatic activity, inhibited 25416781 1 1 0 inhibitory effect on the transfer of electrons +Thra TR-alpha iso2 DNA-binding; Nuclear receptor; Transcription factor P63059-2 81812 rat K283-sm 27490404 LSGEMAVkREQLKNG Hormone_recep transcription, altered 22930759 4 0 0 +H2AZ1 H2AZ DNA-binding P0C0S5 3015 4q23 human K4-ac 458911 ____AGGkAGKDSGK Histone transcription, induced 18985155 4 14 250 Myc-induced transcriptional activation +Crebbp CBP ACETYLTRANSFERASE; Acetyltransferase; DNA-binding; EC 2.3.1.48; Motility/polarity/chemotaxis; Nuclear receptor co-regulator; Transcription, coactivator/corepressor P45481 12914 16 A1|16 2.4 cM mouse K999-sm 3726905 DVPMLEMkTEVQTDD molecular association, regulation transcription, inhibited DAXX(INDUCES); HDAC2(INDUCES) 16287980 1 0 0 +LMNA lamin A/C Cytoskeletal P02545 4000 1q22 human K201-sm 8545502 ENRLQTMkEELDFQK Filament intracellular localization 18606848 1 0 0 increased cell death +MSH3 MSH3 DNA repair, damage P20585 4437 5q14.1 human K98-ac 9925423 LENDGPVkKKVKKVQ intracellular localization 32900932 1 0 1 +PTK2 FAK EC 2.7.10.2; KINASE; Kinase, protein; Protein kinase, TK; Protein kinase, tyrosine (non-receptor) Q00944 396416 chicken Y863-p 447965 PAGNQHIyQPVGKPD activity, induced; phosphorylation; enzymatic activity, induced 12370821; 9790958 75 21 307 +Cgas cGAS EC 2.7.7.86 Q8C6L5 214763 9|9 E1 mouse K217-sm 59117703 NEFDVMFkLEVPRIE Mab-21 protein stabilization 27637147 1 0 0 +PRMT5 PRMT5 Cell cycle regulation; EC 2.1.1.125; METHYLTRANSFERASE; Methyltransferase; Methyltransferase, protein arginine; RNA processing O14744 10419 14q11.2 human T144-p 1267669104 VLTNHIHtGHHSSMF PRMT5_TIM enzymatic activity, induced 30289978 1 0 0 +SMAD3 SMAD3 DNA-binding; Nuclear receptor co-regulator; Transcription factor P84022 4088 15q22.33 human S204-p 451178 NHSMDAGsPNLSPNP molecular association, regulation; intracellular localization; activity, inhibited transcription, induced; transcription, inhibited; signaling pathway regulation; transcription, altered; cell growth, altered TGFBR1(INDUCES) 10197981; 15520018; 16156666; 20659902; 20736297; 34003249; 34360888; 34504019 17 0 0 inhibits TGF-B signaling +CDKN1A p21Cip1 Cell cycle regulation; Inhibitor P38936 1026 6p21.2 human K161-ac 12615906 KRRLIFSkRKP____ protein stabilization; molecular association, regulation cell cycle regulation; carcinogenesis, inhibited; cell growth, inhibited C8A(DISRUPTS) 20154723; 23238566 2 1 0 induces senescence and DNA-damage-induced cell cycle arrest +ERGIC3 SDBCAG84 Membrane protein, integral; Membrane protein, multi-pass; Motility/polarity/chemotaxis; Vesicle Q9Y282 51614 20q11.22 human K6-ub 63727764 __MEALGkLKQFDAY protein degradation 31142615 1 4 0 trafficking and secretion of alpha1-antitrypsin and haptoglobin +MDM2 MDM2 EC 6.3.2.-; EC 6.3.2.19; Inhibitor; Ligase; NEDDYLATION LIGASE; Neddylation Ligase; Nucleolus; Oncoprotein; UBIQUITIN LIGASE; Ubiquitin conjugating system; Ubiquitin ligase Q00987 4193 12q15 human T419-p 448132 KEFEREEtQDKEESV molecular association, regulation; enzymatic activity, inhibited; protein conformation p53(DISRUPTS) 21986495 2 2 0 oligomerization inhibited +Shc1 SHC1 iso2 Adaptor/scaffold; Apoptosis; Mitochondrial; Motility/polarity/chemotaxis P98083-2 20416 3 F1|3 39.11 cM mouse Y313-p 448511 ELFDDPSyVNIQNLD molecular association, regulation; phosphorylation cell motility, induced; cell motility, altered; apoptosis, inhibited GRB2(INDUCES) 18273058; 23277357 42 91 1971 required for ErbB2- and TGFB mediated tumor metastasis to the lungs.; metastatic spread of tumors; required for migration and invasion of ERB2-expressing cells +STK4 MST1 Autophagy; EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, STE; Protein kinase, Ser/Thr (non-receptor) Q13043 6789 20q13.12 human S82-p 12057400 SIMQQCDsPHVVKYY Pkinase molecular association, regulation; intracellular localization; enzymatic activity, induced apoptosis, altered MST1(INDUCES) 20028971 1 0 0 +Ikzf1 Ikaros C2H2-type zinc finger protein; DNA-binding; Transcription factor Q03267 22778 11 A1|11 7.02 cM mouse S293-p 15404028 LSDMPYDsANYEKED molecular association, regulation; intracellular localization DNA(DISRUPTS) 18223295 1 1 1 +PITPNC1 PITPNC1 Lipid-binding Q9UKF7 26207 17q24.2 human S299-p 478664 KDRPRKKsAPETLTL activity, induced; protein stabilization; molecular association, regulation 14-3-3 beta(INDUCES); 14-3-3 epsilon(INDUCES) 21728994; 26977884 2 19 78 +STK3 MST2 Autophagy; EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, STE; Protein kinase, Ser/Thr (non-receptor) Q13188 6788 8q22.2 human T117-p 12615900 IIRLRNKtLIEDEIA Pkinase molecular association, regulation; intracellular localization; enzymatic activity, inhibited; phosphorylation carcinogenesis, induced; apoptosis, altered; signaling pathway regulation; cell growth, altered MST2(DISRUPTS); RASSF1(DISRUPTS); RAF1(INDUCES) 20086174; 20231902 2 0 1 inhibits MST2 T180 autophosphorylation +TTN Titin EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, CAMK; Protein kinase, Ser/Thr (non-receptor) Q8WZ42 7273 2q31.2 human Y32341-p 448692 LFTAPEYyAPEVHQH Pkinase enzymatic activity, induced 9804419 1 0 0 +Gli2 GLI2 C2H2-type zinc finger protein; Oncoprotein; Transcription factor Q0VGT2 14633 1 E2.3|1 52.17 cM mouse S662-p 57786400 GSAPNNDsGMEMPGT protein degradation transcription, inhibited; translation, inhibited 27484899 1 1 0 overexpression of GLI2 S662A stabilized and increased during mES cell differentiation enhances transcript expression +TET1 TET1 DNA-binding; EC 1.14.11.n2; Oxidoreductase Q8NFU7 80312 10q21.3 human T1164-p 1881549500 DRRKKKPtVVSYQEN protein stabilization carcinogenesis, induced; cell growth, induced; apoptosis, inhibited; transcription, induced 36989375 1 0 0 +Plekhg5 PLEKHG5 Q66T02 269608 4|4 E2 mouse S806-p 27434500 PTILRKSsNSLDSEH molecular association, regulation; intracellular localization MPDZ(DISRUPTS) 23253477 1 0 0 inhibits EC recruitment to cell junction +TRPC3 TRPC3 Channel, cation; Membrane protein, integral; Membrane protein, multi-pass Q13507 7222 4q27 human S785-p 454431 PPFSLVPsPKSFVYF activity, inhibited 15533987; 16331690 2 0 0 +GRK1 GRK1 EC 2.7.11.14; KINASE; Kinase, protein; Protein kinase, AGC; Protein kinase, Ser/Thr (non-receptor) P28327 281457 cow S488-p 2530401 IQDVGAFsTVKGVAF molecular association, regulation; enzymatic activity, inhibited PTN(DISRUPTS) 7797516 3 1 0 +DDAH2 DDAH2 Apoptosis; EC 3.5.3.18; Hydrolase O95865 23564 6p21.33 human S245-p 1872776106 GGGDLPNsQEALQKL intracellular localization; phosphorylation; enzymatic activity, induced signaling pathway regulation 33850055 1 1 0 regulates RLR signaling, regulates DRP1 anf IRF3 phosphorylation +APBA3 APBA3 Motility/polarity/chemotaxis O96018 9546 19p13.3 human S7-p 29668009 _MDFPTIsRSPSGPP molecular association, regulation cell growth, induced HIF1AN(INDUCES) 24164895 1 1 0 +H3c1 H3 DNA-binding P68433 360198 13|13 A3.1 mouse K9-m1 1458609 RTKQTARkSTGGKAP Histone endocytosis, altered; chromatin organization, altered; apoptosis, induced; cell adhesion, altered; transcription, inhibited 19910458; 33195484 34 19 14 regulates spermatogenesis, spermatid elongation-chromatin condensation in spermatids and germ cell apoptosis; axon guidance +HCK Hck EC 2.7.10.2; KINASE; Kinase, protein; Oncoprotein; Protein kinase, TK; Protein kinase, tyrosine (non-receptor) P08631 3055 20q11.21 human Y411-p 448168 RVIEDNEyTAREGAK PK_Tyr_Ser-Thr carcinogenesis, induced 34132782 13 70 2093 +NR5A2 NR5A2 DNA-binding; Nuclear receptor; Transcription factor O00482 2494 1q32.1 human S510-p 456465 LPEIRAIsMQAEEYL Hormone_recep activity, induced; intracellular localization transcription, induced 16109788; 37285077 2 0 0 +IRF9 IRF9 DNA-binding; Transcription factor Q00978 10379 14q12 human S253-p 1881230102 EPSGSESsMEQVLFP transcription, altered 36662450 1 1 0 +NR3C2 MCR DNA-binding; Nuclear receptor P08235 4306 4q31.23 human K89-sm 3144808 GILTSDIkTELESKE transcription, induced; transcription, inhibited 14500761; 17105732 3 0 0 Ubc9 can be a transcriptional mineralocorticoid receptor coactivator. +TARDBP TDP-43 RNA-binding Q13148 23435 1p36.22 human S404-p 3084635 FNGGFGSsMDSKSSG molecular association, regulation; intracellular localization; phosphorylation RNA splicing, inhibited; RNA stability, inhibited TDP-43(DISRUPTS) 22198567; 24466128; 34107054; 35112738 14 2 0 primes phosphorylation at other sites; promotes cytoplasmic aggregation +GLS glutaminase iso3 Amino Acid Metabolism - alanine, aspartate and glutamate; Amino Acid Metabolism - arginine and proline; EC 3.5.1.2; Energy Metabolism - nitrogen; Hydrolase; Mitochondrial; Other Amino Acids Metabolism - D-Glutamine and D-glutamate O94925-3 2744 2q32.2 human S314-p 937769500 RYVGKEPsGLRFNKL Glutaminase enzymatic activity, induced cell differentiation, inhibited; cell growth, induced 29515166 1 0 0 +MASTL MASTL EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, AGC; Protein kinase, Ser/Thr (non-receptor) Q96GX5 84930 10p12.1 human T299-p 1269647500 QSRKRLAtSSASSQS protein degradation; enzymatic activity, induced cell cycle regulation; carcinogenesis, induced 32123010 2 0 0 +RUNX3 AML2 DNA-binding; Transcription factor Q13761 864 1p36.11 human T212-p 3952612 RMRVTPStPSPRGSL protein degradation; molecular association, regulation; ubiquitination; activity, inhibited carcinogenesis, induced PIN1(INDUCES) 22580604 1 1 4 The downstream effects occur in the presence of PIN1 +SMAD3 SMAD3 DNA-binding; Nuclear receptor co-regulator; Transcription factor P84022 4088 15q22.33 human T388-p 1243500 GAEYRRQtVTSTPCW MH2 molecular association, regulation transcription, induced; transcription, inhibited CDK8(INDUCES); SMAD4(INDUCES); TUBB2B(INDUCES) 21868450; 24485922 3 1 0 ACTA2, collagen I, and fibronectin gene transcription ; cGMP-induced inhibition of SERPINE1 transcriptional activity +PKN3 PKN3 EC 2.7.11.13; KINASE; Kinase, protein; Protein kinase, AGC; Protein kinase, Ser/Thr (non-receptor) Q6P5Z2 29941 9q34.11 human T718-p 448346 GFGDRTStFCGTPEF Pkinase enzymatic activity, induced 15282551 2 4 62 +ARHGDIB RhoGDI beta Cell adhesion; G protein regulator, misc.; Motility/polarity/chemotaxis P52566 397 12p12.3 human Y24-p 448978 ELDSKLNyKPPPQKS Rho_GDI molecular association, regulation; intracellular localization carcinogenesis, induced; cell motility, induced CDC42(DISRUPTS); RHOA(DISRUPTS); RAC1(DISRUPTS); RHOC(DISRUPTS) 19321744; 31075185; 32903764 4 7 342 +GRM7 mGluR7 GPCR, family 3; Membrane protein, integral; Membrane protein, multi-pass; Receptor, GPCR Q14831 2917 3p26.1 human K889-sm 25042302 DRPNGEAkTELCENV sumoylation endocytosis, altered 26631532 2 0 0 +RB1 Rb Nuclear receptor co-regulator; Oncoprotein; Transcription, coactivator/corepressor; Tumor suppressor P06400 5925 13q14.2 human K810-m1 34823403 NIYISPLkSPYKISE Rb_C molecular association, regulation; protein conformation; phosphorylation cell cycle regulation; DNA repair, induced; carcinogenesis, inhibited; cell growth, inhibited; transcription, induced; transcription, inhibited PHF20L1(INDUCES); MYST1(INDUCES); 53BP1(INDUCES) 21119616; 25049398; 28841214 4 2 0 PHF20L1 shows more specificity for RbK810me1 +Stat3 STAT3 DNA-binding; Motility/polarity/chemotaxis; Nuclear receptor co-regulator; Transcription factor P42227 20848 11 D|11 63.82 cM mouse K685-ac 458927 PKEEAFGkYCRPESQ acetylation; intracellular localization; phosphorylation cell differentiation, induced; transcription, inhibited SIRT1(INDUCES) 19295512; 26923837; 28445726 27 2 0 nuclear localization; SIRT1 activation inhibitss Th17 cell differentiation through STAT3 deacetylation; SIRT1 downregulates phosphorylation at STAT3-Y705 and transactivation, deacetylation of STAT3 +RAB11FIP3 RAB11FIP3 O75154 9727 16p13.3 human S102-p 25126702 GPRGQLAsPDAPGPG intracellular localization 22401586 1 6 0 Phosphorylation at S102 leads to increase in number of binucleate cells and defective cytokinesis +POLR1E POLR1E Nucleolus; Nucleotide Metabolism - purine; Nucleotide Metabolism - pyrimidine Q9GZS1 64425 9p13.2 human K373-ac 11325050 KRMMEIAkAMRLKIS RNA_pol_I_A49 molecular association, regulation transcription, inhibited DNA(DISRUPTS) 24207024 1 1 0 hypoacetylation promotes Pol I transcription +SNAI2 Snail2 Apoptosis; C2H2-type zinc finger protein; Motility/polarity/chemotaxis; Transcription factor O43623 6591 8q11.21 human S100-p 25603907 DTSSKDHsGSESPIS protein degradation; intracellular localization cell motility, inhibited; transcription, induced CHIP(INDUCES) 22727060; 23851495 2 1 0 transcriptional activity of E-cadherin; Snail2 luciferase construct, may affect lung metastasis in NSCLC.; WT localized in nucleus and cytoplasm, mutants localize in nucleus; mutants enhance epithelial-mesenchymal transition (EMT) +PRKCZ PKCZ EC 2.7.11.13; KINASE; Kinase, protein; Protein kinase, AGC; Protein kinase, Ser/Thr (non-receptor) Q05513 5590 1p36.33 human Y428-p 482866 EILRGEEyGFSVDWW Pkinase protein conformation 17335005 1 0 0 +Epor EPOR Membrane protein, integral; Receptor, cytokine P14753 13857 9 A3|9 7.93 cM mouse Y484-p 3103701 GDSSDGPySHPYENS carcinogenesis, induced; cell growth, induced 27998978 3 0 0 STAT5 acivation +Igf2bp1 IGF2BP1 RNA-binding; Translation Q8CGX0 303477 10q26 rat S181-p 453893 RGQPRQGsPVAAGAP molecular association, regulation; intracellular localization KIF5A(DISRUPTS) RNA(INDUCES) 28500298 3 59 12 IGF2BP1 mobility +Grm5 mGluR5 GPCR, family 3; Membrane protein, integral; Membrane protein, multi-pass; Receptor, GPCR P31424 24418 1q32 rat T840-p 450487 RSAFTTStVVRMHVG receptor inactivation, altered; activity, inhibited 12681368; 14561742 2 4 2 +CLDN4 Claudin-4 Cytoskeletal; Membrane protein, integral; Membrane protein, multi-pass O14493 1364 7q11.23 human Y208-p 451666 RSAAASNyV______ molecular association, regulation cell adhesion, altered ZO1(DISRUPTS) 16236711 2 6 79 Phosphorylation of site increases paracellular permeability through tight junctions. +SIK2 QIK EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, CAMK; Protein kinase, Ser/Thr (non-receptor) Q9H0K1 23235 11q23.1 human S90-p 25120404 YQVMETKsMLYLVTE Pkinase enzymatic activity, induced 27478041 2 1 0 +PPARG PPAR-gamma iso2 DNA-binding; Nuclear receptor; Transcription factor P37231-2 5468 3p25.2 human K79-sm 3617602 QEYQSAIkVEPASPP PPARgamma_N carcinogenesis, inhibited; cell growth, inhibited; transcription, altered 26244663 15 0 0 +ADAM10 ADAM10 Cell adhesion; Cell surface; EC 3.4.24.81; Membrane protein, integral; Motility/polarity/chemotaxis; Protease; Vesicle O14672 102 15q21.3 human S436-p 4697183 NNKFSLCsIRNISQV Reprolysin_2 enzymatic activity, inhibited carcinogenesis, induced; cell motility, induced; cell adhesion, induced 36922678 1 2 0 induces N-cadherin stabilization +ITGB4 ITGB4 iso2 Cell adhesion; Membrane protein, integral; Motility/polarity/chemotaxis; Receptor, misc. P16144-2 3691 17q25.1 human Y1440-p 450141 STTLPRDySTLTSVS activity, induced; molecular association, regulation cell motility, altered; cell adhesion, altered PLCG1(INDUCES); SHC1(INDUCES) 11044453; 20855525; 33883672 6 11 166 promote SFK (Fyn) activation and tumor cell invasion +ZNRF2 ZNRF2 EC 6.3.2.-; EC 6.3.2.19; Ligase; UBIQUITIN LIGASE; Ubiquitin conjugating system; Ubiquitin ligase Q8NHG8 223082 7p14.3 human S19-p 3206973 NGRTRAYsGSDLPSS molecular association, regulation 14-3-3 beta(INDUCES) 19648646 1 32 9 yeast 14-3-3 used for binding assay +GMFG GMF-gamma Actin-binding O60234 9535 19q13.2 human Y104-p 33670301 KPEQQMMyAGSKNRL Cofilin_ADF molecular association, regulation; intracellular localization cell motility, induced; cytoskeletal reorganization ARPC3(DISRUPTS); ARP2(DISRUPTS) 24818551; 30811945 2 0 0 smooth muscle cell migration, regulates lamellipodial and focal adhesions; Actin polymerization and smooth muscle contraction regulation +RACGAP1 MgcRacGAP GAP; GAP, Rac/Rho Q9H0H5 29127 12q13.12 human T249-p 478691 WTRSRRKtGTLQPWN molecular association, regulation cell motility, induced IQGAP1(INDUCES) 24019536 2 5 58 drives pseudopod extension and invasive migration, suppression of Rac activity and concomitant activation of RhoA +Dnm2 DYN2 EC 3.6.5.5; Hydrolase; Microtubule-binding; Motility/polarity/chemotaxis; Vesicle P39054 13430 9 A3|9 7.79 cM mouse S848-p 3059607 GIPPGVPsRRAPAAP receptor internalization, induced; molecular association, regulation endocytosis, induced BIN1(DISRUPTS) 36445308 2 1 0 +ACBD5 ACBD5 iso2 Lipid-binding; Membrane protein, integral Q5T8D3-2 91452 10p12.1 human S263-p 1876128612 HLTSDSDsEVYCDSM molecular association, regulation; phosphorylation VAPB(INDUCES) 35019937 1 1 0 induces phosphorylation at S269 +HDAC7 HDAC7 DEACETYLASE; Deacetylase; EC 3.5.1.98; Hydrolase Q8WUI4 51564 12q13.11 human S358-p 455621 WPLSRTRsEPLPPSA intracellular localization cell motility, altered; cytoskeletal reorganization; transcription, altered; cell growth, altered 15623513; 18509061; 18617643 5 16 18 important for VEGF-induced aorta ring angiogenesis; nucleo-cytoplasmic shuttling +DVL1 DVL1 Inhibitor O14640 1855 1p36.33 human K69-ac 1880010900 EIFDDNAkLPCFNGR intracellular localization transcription, inhibited 31700102 1 1 0 nuclear localization +Syn1 SYN1 Vesicle P09951 24949 Xq11 rat T339-p 2020533 SGNWKTNtGSAMLEQ Synapsin_C molecular association, regulation; intracellular localization neural plasticity; signaling pathway regulation SYP(DISRUPTS) 31148170 1 2 0 regulating glutamate release +INSR INSR iso2 EC 2.7.10.1; KINASE; Kinase, protein; Membrane protein, integral; Protein kinase, TK; Protein kinase, tyrosine (receptor) P06213-2 3643 19p13.2 human Y1349-p 447684 SYEEHIPyTHMNGGK activity, inhibited cell cycle regulation 2026614 15 7 14 +AKT1 Akt1 EC 2.7.11.1; KINASE; Kinase, protein; Oncoprotein; Protein kinase, AGC; Protein kinase, Ser/Thr (non-receptor) P31749 207 14q32.33 human Y326-p 447858 EVLEDNDyGRAVDWW Pkinase enzymatic activity, induced 20606012 3 2 26 Brk induces Akt activation by phosphorylation on Y315,Y326. +TRIM33 TIF1G EC 6.3.2.-; EC 6.3.2.19; KINASE; Kinase, protein; Ligase; Protein kinase, atypical; Transcription, coactivator/corepressor; UBIQUITIN LIGASE; Ubiquitin conjugating system; Ubiquitin ligase Q9UPN9 51592 1p13.2 human Y524-p 15416086 QHMQQQVyAQKHQQL molecular association, regulation; intracellular localization transcription, induced; signaling pathway regulation SMAD3(DISRUPTS) 30177833 1 1 21 regulates TGFB-SMAD2/3 signaling and epithelial to mesenchymal transition +OGT OGT EC 2.4.1.255; Glycan Metabolism - O-glycan biosynthesis; O-GlcNAc TRANSFERASE; Transferase O15294 8473 Xq13.1 human S20-p 3174941 EPTKRMLsFQGLAEL protein stabilization; intracellular localization 29021254 3 15 7 OGT(S20A) attenuates vimentin O-GlcNAcylation and phosphorylation +STAT3 STAT3 DNA-binding; Motility/polarity/chemotaxis; Nuclear receptor co-regulator; Transcription factor P40763 6774 17q21.2 human K49-m2 40439803 DWAYAASkESHATLV STAT_int transcription, induced 25767098 1 1 0 +MLH1 MLH1 Cell cycle regulation; DNA repair, damage; Tumor suppressor P40692 4292 3p22.2 human K377-ub 573763756 STSGSSDkVYAHQMV molecular association, regulation MSH2(INDUCES); MSH6(INDUCES) 30770470 1 3 0 +NCOA3 SRC-3 ACETYLTRANSFERASE; Acetyltransferase; EC 2.3.1.48; Motility/polarity/chemotaxis; Nuclear receptor co-regulator; Transcription, coactivator/corepressor Q9Y6Q9 8202 20q13.12 human S728-p 3217881 VVKQEQLsPKKKENN DUF4927 intracellular localization 22163316 1 18 2 regulates SRC-3 access to condensed chromatin +BLM BLM DNA repair, damage; DNA replication; EC 3.6.4.12; Helicase P54132 641 15q26.1 human S175-p 23086547 SFVTPPQsHFVRVST BLM_N protein degradation; molecular association, regulation; ubiquitination FBXW7(INDUCES) 26028025 1 0 1 +TPH2 TPH2 Amino Acid Metabolism - tryptophan; EC 1.14.16.4; Oxidoreductase Q8IWU9 121278 12q21.1 human S104-p 1033700 RKSRRRSsEVEIFVD molecular association, regulation 14-3-3 epsilon(INDUCES); 14-3-3 gamma(INDUCES) 17973628 1 3 1 +PICK1 PICK1 Adaptor/scaffold; Cell development/differentiation; Ligand, receptor tyrosine kinase Q9NRD5 9463 22q13.1 human S415-p 50642302 KGGSWCDs_______ molecular association, regulation GluR2(INDUCES) 26472923 1 3 0 S415 was essential for binding to GluA2 +CTNNB1 CTNNB1 Actin-binding; Cell adhesion; Motility/polarity/chemotaxis; Nuclear receptor co-regulator; Oncoprotein; Transcription factor P35222 1499 3p22.1 human S29-p 3075000 VSHWQQQsYLDSGIH protein degradation cell motility, altered CTNNA1(INDUCES) 12432063 3 2 4 +IRF2 IRF2 DNA-binding; Transcription factor P14316 3660 4q35.1 human K137-sm 3173816 EDKVKHIkQEPVESS transcription, inhibited 18514056 1 2 0 +LARP6 LARP6 Q9BRS8 55323 15q23 human S451-p 485240 QEKSPGTsPLLSRKM protein degradation 26932461 1 20 0 collagen synthesis +IRAK1 IRAK1 EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, Ser/Thr (non-receptor); Protein kinase, TKL P51617 3654 Xq28 human S144-p 21041600 SSASTFLsPAFPGSQ molecular association, regulation; enzymatic activity, induced transcription, induced PIN1(INDUCES) 21743479; 27790836 2 1 0 +Slc22a1 SLC22A1 Membrane protein, integral; Membrane protein, multi-pass; Transporter; Transporter, SLC family Q63089 24904 1q11 rat S286-p 455610 YYWFVPEsPRWLLSQ Sugar_tr activity, induced 15829703 1 0 0 stimulates ASP+ uptake +RANBP9 RANBP9 Adaptor/scaffold; GAP; GAP, Ras; Nuclear receptor co-regulator Q96S59 10048 6p23 human S181-p 54363506 KFSYIGLsQNNLRVH intracellular localization 26943034 1 0 0 nuclear accumulation +Plcd1 PLCD1 Carbohydrate Metabolism - inositol phosphate; EC 3.1.4.11; Phospholipase P10688 rat S35-p 9993602 LLKVKSSsWRRERFY PH_12 enzymatic activity, induced 19681039 1 0 0 in vitro +RAC1 RAC1 G protein; G protein, monomeric; G protein, monomeric, Rho; Motility/polarity/chemotaxis P63000 5879 7p22.1 human T108-p 27458396 VRHHCPNtPIILVGT Ras molecular association, regulation; intracellular localization; enzymatic activity, inhibited RNA splicing, induced SFRS2(INDUCES); hnRNP A1(INDUCES); PLCG1(DISRUPTS); snRNP A'(INDUCES) 24043306; 33417283 4 1 0 +Syn1 SYN1 Vesicle P09951 24949 Xq11 rat T562-gl 5505102 QAGPPQAtRQASISG phosphorylation 10386995 1 1 0 in the presnce of two GlcNAcs CaM Kinase II activity had a 66% increase in KM with no effect on Vmax or Kcat +KRAS KRas iso2 G protein; G protein, monomeric; G protein, monomeric, Ras; Motility/polarity/chemotaxis; Oncoprotein P01116-2 3845 12p12.1 human S181-p 459210 GKKKKKKsKTKCVIM activity, induced; molecular association, regulation; intracellular localization; protein conformation; phosphorylation cell differentiation, inhibited; apoptosis, altered; carcinogenesis, altered; cell motility, induced; cell growth, induced; cell adhesion, altered; transcription, altered RAF1(DISRUPTS); PDE6D(DISRUPTS); RHOA(INDUCES); Calmodulin(DISRUPTS) 16483930; 18182391; 18458061; 20802526; 25713064; 27791178; 34333552; 34551282 10 0 0 regulates a-E-catenin localization +H2AC11 H2A.1 DNA-binding P0C0S8 8329 6p22.1 human T120-p 482914 AVLLPKKtESHHKAK Histone_H2A_C molecular association, regulation; intracellular localization cell cycle regulation; carcinogenesis, induced; cell growth, induced; chromatin organization, altered; transcription, induced; transcription, inhibited SGO1(INDUCES) DNA(INDUCES) 20929775; 24055156; 26190260; 26399325; 27716482; 30112853; 34312968; 34925867 15 8 0 +Ncor1 N-CoR1 Nuclear receptor co-regulator; Transcription, coactivator/corepressor Q60974 20185 11|11 B2 mouse K1330-sm 3755602 LKYPKQIkRESPPIR transcription, inhibited 16421255 1 0 0 +ETV4 ETV4 DNA-binding P43268 2118 17q21.31 human S73-p 68524600 AEAQVPDsDEQFVPD ETS_PEA3_N protein stabilization; molecular association, regulation COP1(DISRUPTS) 28373072 1 0 0 +CDC7 CDC7 EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, Other; Protein kinase, Ser/Thr (non-receptor) O00311 8317 1p22.2-p22.1 human T376-p 2864203 QVAPRAGtPGFRAPE Pkinase protein degradation; ubiquitination; enzymatic activity, induced 10846177; 27611229 3 1 12 +DDR1 DDR1 EC 2.7.10.1; KINASE; Kinase, protein; Membrane protein, integral; Protein kinase, TK; Protein kinase, tyrosine (receptor) Q08345 780 6p21.33 human Y796-p 457957 RNLYAGDyYRVQGRA PK_Tyr_Ser-Thr activity, induced; molecular association, regulation SHP-2(INDUCES) 16611743; 24509848 2 16 939 phosphorylated in the N211QDDR1 mutant; required for the DDR1-mediated suppression of tyrosine phosphorylation of Stat1 and Stat3, cell migration, branching tubulogenesis +WDR5 WDR5 Adaptor/scaffold P61964 11091 9q34.2 human S49-p 25758598 AGHTKAVsSVKFSPN WD40 cell differentiation, induced; transcription, induced 31072927 1 0 1 myogenesis indeced +Nfatc2 NFAT1 DNA-binding; Transcription factor Q60591 18019 2 H3|2 88.91 cM mouse S182-p 449625 GSSASFIsDTFSPYT transcription, inhibited 11030334 0 1 0 +CDCA5 CDCA5 Cell cycle regulation Q96FF9 113130 11q13.1 human S83-p 3208977 PRRSPRIsFFLEKEN activity, inhibited cell cycle regulation SCC-112(DISRUPTS) 23901111 2 14 0 +CHN2 ARHGAP3 GAP; GAP, Rac/Rho P52757 1124 7p14.3 human S171-p 13790300 EKVSRRLsRSKNEPR molecular association, regulation; intracellular localization; activity, inhibited cell motility, altered RAC1(NOT_REPORTED) 20335173 1 1 0 +CORO1C coronin 1C Actin-binding; Motility/polarity/chemotaxis Q9ULV4 23603 12q24.11 human S463-p 22996300 CNQDERIsKLEQQMA cell growth, inhibited; cell adhesion, induced; cytoskeletal reorganization; cell motility, inhibited 22355754; 23410663 2 0 0 decreased matrix degradation and invasion, increased invadopodia-like extensions in vitro +Wwox WWOX Apoptosis; EC 1.1.1.-; Oxidoreductase; Tumor suppressor Q91WL8 80707 8|8 E1 mouse Y33-p 449043 TTKDGWVyYANHTEE WW molecular association, regulation apoptosis, induced ERK2(INDUCES); ERK1(INDUCES); ZFRA(INDUCES); IkB-alpha(INDUCES) 17567906; 27339895 21 1 0 +Map2 MAP2 iso3 Cytoskeletal; Motility/polarity/chemotaxis P15146-3 25595 9q32 rat K283-ac 62495510 ILVPSEKkVAIIRTP cytoskeletal reorganization 28002468 1 1 0 +ATM ATM DNA repair, damage; EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, Ser/Thr (non-receptor); Protein kinase, atypical; Tumor suppressor Q13315 472 11q22.3 human T1985-p 481859 EEGSQSTtISSLSEK enzymatic activity, inhibited; protein conformation cell cycle regulation; apoptosis, inhibited 27939942 1 1 0 +Tesk1 TESK1 EC 2.7.12.1; KINASE; Kinase, protein; Protein kinase, Ser/Thr (non-receptor); Protein kinase, TKL; Protein kinase, dual-specificity (non-receptor) Q63572 29460 5q22 rat S215-p 452045 EPLAVVGsPYWMAPE PK_Tyr_Ser-Thr enzymatic activity, induced 10207045 1 0 0 in vitro assay +CFTR CFTR Channel, chloride; EC 3.6.3.49; Hydrolase; Membrane protein, integral; Membrane protein, multi-pass; Transporter; Transporter, ABC family P13569 1080 7q31.2 human S686-p 449980 WTETKKQsFKQTGEF CFTR_R activity, induced; protein conformation 12588899; 14695900; 32123855 5 0 0 +KMT5A SETD8 Amino Acid Metabolism - lysine degradation; EC 2.1.1.43; METHYLTRANSFERASE; Methyltransferase; Methyltransferase, protein lysine Q9NQR1 387893 12q24.31 human K172-sm 25090302 LVPFPNQkSEAAEPP transcription, inhibited 21829513 1 0 0 +ELAVL1 HuR RNA-binding Q15717 1994 19p13.2 human S202-p 3197192 LLSQLYHsPARRFGG molecular association, regulation; intracellular localization cell cycle regulation; apoptosis, induced; RNA stability, inhibited; translation, inhibited 14-3-3 theta(INDUCES) RNA(DISRUPTS) 18593881; 22829587; 25088200; 27303922; 30154469; 32047552 9 57 61 recruitmentof miR-4312 and competes HuR to bind to IL-8 transcrip; regulates centrosome function, Cyclin A translation inhibited +FANCA FANCA DNA repair, damage O15360 2175 16q24.3 human S347-p 56793101 VQMQREWsFARTHPL Fanconi_A_N ubiquitination 27449087 1 0 0 +CCT2 CCT2 Chaperone P78371 10576 12q15 human S260-p 472352 GSRVRVDsTAKVAEI Cpn60_TCP1 cell growth, altered 19332537 3 19 249 regulates cell proliferation +MAP3K8 Cot EC 2.7.11.25; KINASE; Kinase, protein; Oncoprotein; Protein kinase, STE; Protein kinase, Ser/Thr (non-receptor) P41279 1326 10p11.23 human S400-p 447712 EDQPRCQsLDSALLE transcription, altered 12138205 4 2 0 +RALA RALA G protein; G protein, monomeric; G protein, monomeric, Ras; Motility/polarity/chemotaxis P11233 5898 7p14.1 human S183-p 483988 RARKMEDsKEKNGKK enzymatic activity, induced carcinogenesis, induced; cell growth, induced 17540176 2 1 0 +HSF1 HSF1 DNA-binding; Transcription factor Q00613 3297 8q24.3 human S303-p 449045 RVKEEPPsPPQSPRV Vert_HS_TF sumoylation; molecular association, regulation; intracellular localization; protein processing; activity, inhibited transcription, inhibited; transcription, altered 14-3-3 epsilon(INDUCES); SUMO1(INDUCES) 12665592; 12917326; 16371476; 25963659; 33493517; 8940068 23 59 5 +RAB5A RAB5A G protein; G protein, monomeric; G protein, monomeric, Rab; Motility/polarity/chemotaxis P20339 5868 3p24.3 human T7-p 33622402 _MASRGAtRPNGPNT intracellular localization cell motility, induced; cytoskeletal reorganization 24872409 1 0 0 +TRAF6 TRAF6 EC 6.3.2.-; Ligase; UBIQUITIN LIGASE; Ubiquitin conjugating system; Ubiquitin ligase Q9Y4K3 7189 11p12 human T266-p 1867864101 ARHLQENtQSHMRML protein degradation; protein stabilization; ubiquitination carcinogenesis, induced; cell motility, induced; autophagy, inhibited 30806153 1 1 0 stabilises CTNNB1 +PIK3R2 PIK3R2 Kinase, lipid; Motility/polarity/chemotaxis O00459 5296 19p13.11 human K598-sm 56709101 INEWLGIkNETEDQY phosphorylation carcinogenesis, inhibited; signaling pathway regulation 26411363 1 0 0 sumolation inhibits PI3KR2 phosphorylation, regulates PI3K pathway activation +Bmal1 BMAL1 DNA-binding; Transcription factor Q9WTL8 11865 7 F1|7 59.17 cM mouse S418-gl 27583502 KFKIKDGsFITLRSR PAS_11 protein stabilization; ubiquitination 23395176 1 0 0 inhibits ubiquitination +CPLX2 CPLX2 Vesicle P84088 281711 cow S115-p 474556 EEEEEEEsILDTVLK Synaphin molecular association, regulation STX1A(INDUCES) 17266930 1 1 0 SNARE complex summarized by Syntaxin binding. +KDM5A JARID1A DEMETHYLASE; Demethylase; EC 1.14.11.-; Nuclear receptor co-regulator; Nucleolus; Oxidoreductase; Transcription factor P29375 5927 12p13.33 human T1225-p 56630500 SRRPRLEtILSLLVS intracellular localization 27292631 1 0 0 JARID1A recruitment to the promoters of AKT-regulated genes +Shc1 SHC1 Adaptor/scaffold; Apoptosis; Mitochondrial; Motility/polarity/chemotaxis P98083 20416 3 F1|3 39.11 cM mouse S36-p 448508 TPPEELPsPSASSLG intracellular localization; phosphorylation apoptosis, altered; apoptosis, induced; transcription, inhibited; transcription, altered 15930121; 16487929; 17077388; 18174162; 19060130; 20547441 20 1 0 induced by cisplatin +HMGN1 HMGN1 DNA-binding; Nuclear receptor co-regulator P05114 3150 21q22.2 human K53-ac 458850 SDKKVQTkGKRGAKG HMG14_17 molecular association, regulation DNA(DISRUPTS) 10753971 1 0 0 +NR3C2 MCR DNA-binding; Nuclear receptor P08235 4306 4q31.23 human S238-p 25692902 QGTPLTCsPNVENRG protein degradation; ubiquitination transcription, inhibited 22798426 1 0 0 +RAF1 RAF1 EC 2.7.11.1; KINASE; Kinase, protein; Oncoprotein; Protein kinase, Ser/Thr (non-receptor); Protein kinase, TKL P05625 396245 chicken S338-p 447742 RPRGQRDsSYYWEIE intracellular localization; enzymatic activity, induced apoptosis, inhibited 12843393; 12952943 92 2 7 +ETV5 ERM DNA-binding; Transcription factor P41161 2119 3q27.2 human K89-sm 2887207 APPPTKIkRELHSPS ETS_PEA3_N transcription, inhibited 15857832; 18243147 2 0 0 +SLC12A3 NCCT Membrane protein, integral; Membrane protein, multi-pass; Transporter; Transporter, SLC family P55017 6559 16q13 human K909-ub 27200746 NPRAEHTkRFEDMIA SLC12 protein degradation; ubiquitination; activity, inhibited; phosphorylation endocytosis, induced 29021560 1 1 0 NCC transport activity decreased. phosphorylation inhibited +Mapkapk5 MAPKAPK5 EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, CAMK; Protein kinase, Ser/Thr (non-receptor); Tumor suppressor O54992 17165 5|5 F mouse K364-ac 28070703 NPILRKRkLLGTKPK enzymatic activity, induced carcinogenesis, inhibited; cell growth, inhibited 23685072 1 0 0 oncogene-induced senescence +NEDD9 Cas-L Adaptor/scaffold; Motility/polarity/chemotaxis Q14511 4739 6p24.2 human S780-p 348338200 RNKVMNSsNQLCEQL CAS_C molecular association, regulation; intracellular localization cell motility, induced PLK1(NOT_REPORTED) 29191835 1 1 0 localization of HEF1 to FAs +Nfat5 NFAT5 Transcription factor Q9WV30 54446 8 D3|8 53.93 cM mouse S155-p 2715402 PEDLLDNsRMSCQDE intracellular localization 22992674 3 4 2 regulates nuclear localization +NCOR2 SMRT Nuclear receptor co-regulator; Transcription, coactivator/corepressor Q9Y618 9612 12q24.31 human S2407-p 454664 AKVSGRPsSRKAKSP protein degradation; intracellular localization transcription, induced 15494311 1 0 0 +DAP DAP Autophagy P51397 1611 5p15.2 human S3-p 14572132 _____MSsPPEGKLE activity, inhibited autophagy, altered 20537536 1 15 0 dephosphorylated form of DAP acts as an active suppressor of autophagy +Wwox WWOX Apoptosis; EC 1.1.1.-; Oxidoreductase; Tumor suppressor Q91WL8 80707 8|8 E1 mouse S14-p 454203 AGLDDTDsEDELPPG protein degradation 27339895 2 26 6 IkB-alpha degradation +ARHGDIA RhoGDI alpha Apoptosis; Cell adhesion; Cell development/differentiation; G protein regulator, misc.; Motility/polarity/chemotaxis P52565 396 17q25.3 human K138-sm 31089519 HTYRKGVkIDKTDYM Rho_GDI phosphorylation cell cycle regulation; carcinogenesis, inhibited; cell growth, inhibited; transcription, inhibited; signaling pathway regulation 24342356 2 2 0 downregulation of Cyclin D1 expression, and MEK1/2/Erk inhibition of C-Jun/AP1, repression of cyclin D1 transcription +NPM1 NPM1 Nucleolus; Oncoprotein; RNA-binding; Translation P06748 4869 5q35.1 human K215-ac 8537512 NQNGKDSkPSSTPRS molecular association, regulation; intracellular localization transcription, altered H3(INDUCES) 19581289 1 5 0 K212/215/229/230/257/267/292R mutant +Kif3a KIF3A Microtubule-binding; Motor P28741 16568 11 B1.3|11 31.97 cM mouse T674-p 33668514 MKLERPRtSKGKARP autophagy, inhibited; signaling pathway regulation 32935890 3 0 0 mildly affects cilia length, Hedgehog signaling and autophagy +MRPL10 MRPL10 Mitochondrial; Ribosomal; Translation Q3MHY7 515014 cow K169-ac 12674402 KEMVRILkSVPFLPL Ribosomal_L10 translation, induced 20042612 1 1 0 downregulates protein synthesis +Irak1 IRAK1 EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, Ser/Thr (non-receptor); Protein kinase, TKL B2RYH5 363520 Xq37 rat K355-ub 7452908 LDERLMPkLGDFGLA Pkinase protein degradation 21708940 2 4 0 +Map2 MAP2 iso3 Cytoskeletal; Motility/polarity/chemotaxis P15146-3 25595 9q32 rat K338-ac 62495504 QVQIVTKkIDLSHVT Tubulin-binding cytoskeletal reorganization 28002468 1 1 0 +Rag2 RAG2 Cell development/differentiation; Histone-binding; Lipid-binding P21784 19374 2 E2|2 53.87 cM mouse T490-p 455560 QIARALQtPKRNPPL RAG2_PHD protein degradation; molecular association, regulation; intracellular localization Other(DISRUPTS) 12205088; 31075127 4 0 0 T490A mutation reduces RAG2 rate of diffusion in the nucleus; T490A mutation increases RAG2 colocalization with H3K4me3 +AKAP8 AKAP8 Adaptor/scaffold; Cell cycle regulation; Mitochondrial; RNA-binding O43823 10270 19p13.12 human Y80-p 40420001 PAMHMASyGPEPCTD molecular association, regulation 25770215 1 0 0 Phenylalanine mutants inhibited dissociation from nuclear structures; structural chromatin changes +Map2 MAP2 iso3 Cytoskeletal; Motility/polarity/chemotaxis P15146-3 25595 9q32 rat K298-ac 62495517 PKSPATPkQLRLINQ cytoskeletal reorganization 28002468 1 1 0 +GARS1 GARS Aminoacyl-tRNA synthetase; EC 6.1.1.14; Ligase; Mitochondrial; Translation; Translation regulation P41250 2617 7p14.3 human K553-ub 10839688 GKTFQLTkDMINVKR tRNA-synt_2b protein degradation 26676607 0 3 1 +ANAPC1 APC1 Cell cycle regulation; Ubiquitin conjugating system Q9H1A4 64682 2q13 human S355-p 455825 AALSRAHsPALGVHS activity, induced; activity, inhibited cell cycle regulation 14657031; 29084198 2 39 2 +HNRNPK hnRNP K iso2 RNA splicing; RNA-binding; Spliceosome P61978-2 3190 9q21.32 human S116-p 452369 EEGLQLPsPTATSQL intracellular localization 20960454 4 38 22 +Ccnt1 CCNT1 Cell cycle regulation; Transcription initiation complex Q9QWV9 12455 15|15 F1 mouse K390-ac 11322420 PSAKVSLkEYRAKHA molecular association, regulation; enzymatic activity, induced transcription, induced BCDIN3(DISRUPTS); HEXIM1(DISRUPTS) 19387490 3 2 0 enhances CDK9/cyclin T1 transcriptional activity, disrupting HEXIM1 and BCDIN3 association +APAF1 APAF Apoptosis O14727 317 12q23.1 human S357-p 23003807 FKRIRKSsSYDYEAL NB-ARC molecular association, regulation CYC1(INDUCES) 22246185 1 0 0 +ADRB2 ADRB2 GPCR, family 1; Membrane protein, integral; Membrane protein, multi-pass; Receptor, GPCR P07550 154 5q32 human S356-p 458917 AYGNGYSsNGNTGEQ receptor internalization, induced; protein degradation; molecular association, regulation; receptor desensitization, altered; intracellular localization; receptor internalization, altered; protein conformation cell motility, induced; signaling pathway regulation ARR3(INDUCES); ARRB2(INDUCES) 11040066; 16407241; 16980556; 18801735; 20193676; 20345371; 21868357; 22275358; 25395624; 31088898 27 2 0 B-arrestin recruitment; B-arrestin mediated signaling +RAD50 RAD50 Adaptor/scaffold; DNA repair, damage; EC 3.6.-.-; Hydrolase Q92878 10111 5q31.1 human S635-p 453831 KLFDVCGsQDFESDL intracellular localization cell cycle regulation 21757780 3 20 11 sites of DNA damage, mediates DNA repair +BAX BAX Apoptosis; Membrane protein, integral; Mitochondrial; Tumor suppressor Q07812 581 19q13.33 human T186-p 28847909 GVLTASLtIWKKMG_ TM intracellular localization apoptosis, induced 23907458 1 0 0 +AKT2 Akt2 EC 2.7.11.1; KINASE; Kinase, protein; Oncoprotein; Protein kinase, AGC; Protein kinase, Ser/Thr (non-receptor) P31751 208 19q13.2 human S474-p 448520 RTHFPQFsYSASIRE Pkinase_C intracellular localization; enzymatic activity, induced signaling pathway regulation 11507039; 19277985; 26711268; 9374542 37 9 55 involved in SH2B1/PSM regulated insulin signaling pathway +KNG1 KNG1 Cell adhesion; Contractile; Inhibitor; Motility/polarity/chemotaxis; Secreted; Secreted, signal peptide P01042 3827 3q27.3 human S391-p 5024713 GFSPFRSsRIGEIKE protein processing 18844446 1 0 0 inhibits cleavage by kallikrein in vitro +CDC25A CDC25A EC 3.1.3.48; Motility/polarity/chemotaxis; PHOSPHATASE; Protein phosphatase, dual-specificity P30304 993 3p21.31 human S519-p 26342101 KSKREMYsRLKKL__ protein degradation cell cycle regulation 21376736 1 1 0 proteasome mediated degradation +Bcar1 P130Cas iso2 Adaptor/scaffold; Motility/polarity/chemotaxis Q63767-2 25414 19q12 rat Y253-p 448721 APGSQDIyDVPPVRG cell motility, altered 12972425 14 44 723 +Taok2 TAO2 Apoptosis; EC 2.7.11.1; KINASE; Kinase, protein; Membrane protein, integral; Membrane protein, multi-pass; Protein kinase, STE; Protein kinase, Ser/Thr (non-receptor) Q6ZQ29 381921 7|7 F3 mouse T475-p 23150863 RNRDHFAtIRTASLV molecular association, regulation cytoskeletal reorganization MYL5(INDUCES); DBN1(INDUCES) 25456499 1 1 1 spine development +STK11 LKB1 Autophagy; EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, CAMK; Protein kinase, Ser/Thr (non-receptor); Tumor suppressor Q15831 6794 19p13.3 human T336-p 448150 KDRWRSMtVVPYLED enzymatic activity, induced 12805220 2 0 0 STRAD increases LKB1 activation +DDX21 DDX21 EC 3.6.4.13; Helicase; Nucleolus; RNA processing; RNA-binding Q9NR30 9188 10q22.1 human K600-ac 36296739 HFKQSAEkLIEEKGA enzymatic activity, inhibited transcription, inhibited 28790157 1 0 0 Inhibits DDX21 helicase activity, impairs genomic stability, R-loop mediated stalling of RNA polymerase +TRIM50 TRIM50 EC 6.3.2.-; Ligase; UBIQUITIN LIGASE; Ubiquitin conjugating system; Ubiquitin ligase Q86XT4 135892 7q11.23 human K373-ac 31914104 IKGTASRkGKLNRSP SPRY ubiquitination; intracellular localization 24308962 1 0 0 inhibits ubiquitination +PCYT1A PCYT1A EC 2.7.7.15; Lipid Metabolism - glycerophospholipid; Transferase P49585 5130 3q29 human Y359-p 463968 SRHKAAAyDISEDEE intracellular localization 32186954 2 2 35 +SPRY2 SPRY2 Adaptor/scaffold; Inhibitor; Motility/polarity/chemotaxis O43597 10253 13q31.1 human S112-p 465675 APLSRSIsTVSSGSR protein degradation; molecular association, regulation; protein stabilization; ubiquitination BRAF(DISRUPTS); NEDD4 iso4(INDUCES) 16479008; 19690147; 19864419; 37045830 5 2 1 +GATA1 GATA1 DNA-binding; Transcription factor P15976 2623 Xp11.23 human K312-ac 459079 RNRKASGkGKKKRGS molecular association, regulation transcription, altered DNA(INDUCES) 16888089 6 1 0 +FUNDC1 FUNDC1 Membrane protein, multi-pass; Mitochondrial Q8IVP5 139341 Xp11.3 human Y18-p 11086746 YESDDDSyEVLDLTE molecular association, regulation; protein conformation autophagy, induced; autophagy, inhibited LC3B(DISRUPTS) 24746696; 27653272; 27757847 6 3 0 mitophagy inhibited, weakens the binding affinity due to electrostatic repulsion; Y18A mutation abolishes mitophagic activity +Nefm NFM Cytoskeletal P08553 18040 14|14 D1 mouse S669-p 448045 ADKKKAEsPVKEKAV cytoskeletal reorganization 19193875 4 23 1 slightly altered axoplasmic organization in 7S/A mice mutant +DYNLRB1 DYNLRB1 Motility/polarity/chemotaxis Q9NP97 83658 20q11.22 human S73-p 27523608 LTFLRIRsKKNEIMV Robl_LC7 molecular association, regulation transcription, induced DNCLI1(INDUCES) 23333499 1 0 0 +ATR ATR EC 2.7.11.1; KINASE; Kinase, protein; Membrane protein, integral; Protein kinase, Ser/Thr (non-receptor); Protein kinase, atypical Q13535 545 3q23 human T1989-p 2226546 LCFPENEtPPEGKNM FAT molecular association, regulation; phosphorylation; enzymatic activity, induced cell cycle regulation; carcinogenesis, induced; cell growth, induced; chromatin organization, altered; apoptosis, inhibited TOPBP1(INDUCES) 21705319; 21777809; 24876101; 28592488; 33848395; 34676045; 35798878 20 16 36 +AGO2 AGO2 EC 3.1.26.n2; RNA processing; RNA-binding Q9UKV8 27161 8q24.3 human S828-p 31082605 EHDSAEGsHTSGQSN molecular association, regulation; activity, inhibited; phosphorylation transcription, inhibited RNA(DISRUPTS) 28114302 3 4 0 regulates miRNA silencing; induces phosphorylation at S831 +Hcn4 HCN4 Channel, cation; Membrane protein, integral; Membrane protein, multi-pass O70507 330953 9|9 B mouse Y554-p 1240810 TRQRIHDyYEHRYQG activity, induced 16079136 2 0 0 Y476F mutation in Hcn2 and Y554F mutation in Hcn4, abolishes the effect of PP2 on activation. +ACLY ACLY Carbohydrate Metabolism - citrate (TCA) cycle; EC 2.3.3.8; Lyase; Transferase P53396 47 17q21.2 human K540-ub 59144800 FTGDHKQkFYWGHKE CoA_binding protein degradation carcinogenesis, inhibited; cell growth, inhibited 27664236 1 0 0 +CFL1 Cofilin-1 Cytoskeletal; Motility/polarity/chemotaxis; Nuclear receptor co-regulator P23528 1072 11q13.1 human Y68-p 449642 GQTVDDPyATFVKML Cofilin_ADF protein degradation; ubiquitination cell motility, altered; cytoskeletal reorganization 19802004 1 19 480 inhibits cofilin activity to reduce F-actin contents +H3C1 H3 DNA-binding P68431 8350 6p22.2 human K14-ac 458954 ARKSTGGkAPRKQLA Histone activity, induced; molecular association, regulation; intracellular localization; protein conformation; enzymatic activity, induced cell cycle regulation; carcinogenesis, induced; carcinogenesis, inhibited; apoptosis, induced; cell growth, inhibited; transcription, induced; transcription, altered; neural plasticity; DNA repair, induced; chromatin organization, altered; cell differentiation, induced; cell growth, induced; transcription, inhibited polybromo 1(INDUCES); SMARCA2(INDUCES); SMARCC2(INDUCES); 14-3-3 zeta(INDUCES); BRD7(INDUCES); MLL(INDUCES); SMARCA4(INDUCES); requiem(INDUCES); DPF3(INDUCES); BRD4(INDUCES); TIF1G(INDUCES) DNA(INDUCES); DNA(DISRUPTS) 12039950; 16354694; 17305432; 17409387; 17498659; 17560255; 17567990; 18179771; 18234970; 18418070; 18418385; 18985155; 19229332; 19828451; 19889207; 20043883; 20068219; 20080105; 20094059; 20159609; 20224553; 20368734; 20613843; 20720004; 20829218; 21097519; 21196933; 21726812; 21791614; 22144178; 22408259; 23287868; 23653357; 23844048; 26967163; 28167529; 28716899; 31822509; 32188943; 32623337; 32733069; 33408182; 35222362; 36060800; 36165173 162 31 355 p53 regulates histone H3K27me3 and H3K9/K14ac in the miR-1246 promoter dependent on recruited JMJD3/EP300/CBP. +KIF2B KIF2B Microtubule-binding; Motor Q8N4N8 84643 17q22 human S200-p 25247531 EYRRHLDsSKISVLE intracellular localization cell cycle regulation 22535524 1 1 0 +RBL2 Rb-like 2 Transcription, coactivator/corepressor; Tumor suppressor Q08999 5934 16q12.2 human S1044-p 449739 YPFVRTGsPRRIQLS molecular association, regulation cell cycle regulation E2F4(DISRUPTS) 11157749; 12006580 2 1 9 +EPAS1 HIF2A DNA-binding; Transcription factor Q99814 2034 2p21 human S435-p 1874020200 GKAILPPsQPWATEL protein stabilization; molecular association, regulation; ubiquitination carcinogenesis, induced; cell growth, induced; transcription, induced EGLN1(DISRUPTS) 34211090 1 1 0 inhibits ubiquitination +EIF4ENIF1 4E-T Karyopherin; Nuclear import; Translation Q9NRA8 56478 22q12.2 human S374-p 7322864 GLEQAILsPGQNSGN EIF4E-T molecular association, regulation 4E-T(INDUCES) 22966201 1 15 24 required for processing bodies (PBs or P bodies) assembly +Nos1 nNOS Amino Acid Metabolism - arginine and proline; EC 1.14.13.39; Oxidoreductase P29476 24598 12q16 rat K33-ac 2459104 GGLGFLVkERVSKPP PDZ activity, induced 18415985 2 1 0 +CLASP2 CLASP2 Cytoskeletal; Motility/polarity/chemotaxis O75122 23122 3p22.3 human S1013-p 4753159 HSMPTHSsPRSRDYN molecular association, regulation; phosphorylation cell cycle regulation; cytoskeletal reorganization PLK1(INDUCES) 23045552 1 15 2 primes for phosphorylation at other sites +SLC4A4 SLC4A4 Membrane protein, integral; Membrane protein, multi-pass; Transporter; Transporter, SLC family Q9Y6R1 8671 4q13.3 human S235-p 4699765 GKTVSSAsRMFTNPD Band_3_cyto protein conformation; activity, inhibited 30377224 1 8 0 +GALNT2 GALNT2 EC 2.4.1.41; Glycan Metabolism - O-glycan biosynthesis; Membrane protein, integral; Transferase Q10471 2590 1q42.13 human K363-ac 25336506 RVGHVFRkQHPYTFP enzymatic activity, inhibited; O-GalNAc glycosylation 21651894 0 1 0 inhibits glycosylation of mucin +Nfatc2 NFAT1 DNA-binding; Transcription factor Q60591 18019 2 H3|2 88.91 cM mouse S179-p 447844 ASSGSSAsFISDTFS transcription, inhibited 11030334 0 1 0 +Mapk13 P38D EC 2.7.11.24; KINASE; Kinase, protein; Protein kinase, CMGC; Protein kinase, Ser/Thr (non-receptor) Q9Z1B7 26415 17|17 A3.3 mouse T180-p 4787496 RHTDTEMtGYVVTRW Pkinase enzymatic activity, induced 10066767; 9374491 4 7 382 +SIRT1 SIRT1 Apoptosis; DEACETYLASE; Deacetylase; EC 3.5.1.-; Nuclear receptor co-regulator Q96EB6 23411 10q21.3 human T530-p 6006905 YLSELPPtPLHVSED molecular association, regulation; acetylation; intracellular localization; enzymatic activity, induced cell cycle regulation; autophagy, induced; cytoskeletal reorganization ATG7(INDUCES); PABP 1(INDUCES); REG3G(DISRUPTS) 19107194; 20027304; 24011073; 28756945; 30517871 7 3 40 suppress centriole duplication +PTPN5 STEP EC 3.1.3.48; Membrane protein, multi-pass; Motility/polarity/chemotaxis; PHOSPHATASE; Protein phosphatase, tyrosine (non-receptor) P54829 84867 11p15.1 human S245-p 448294 GLQERRGsNVSLTLD protein stabilization; molecular association, regulation; enzymatic activity, inhibited ERK1(DISRUPTS); ERK2(DISRUPTS) 20427654; 21777200; 26574547 9 0 0 +Sox6 SOX6 DNA-binding P40645 20679 7 F1|7 61.29 cM mouse T119-p 4706790 MNSVTFGtPERRKGS apoptosis, induced 24662752 1 4 0 CDK5 post-translational regulation of Sox6 expression, CDK5 hyperactivity leading to neuronal apoptosis +Neurog2 neurogenin 2 Transcription factor P70447 11924 3|3 G2 mouse Y241-p 457462 SPGSDVDyWQPPPPE cell motility, altered 16202708 1 0 0 Phosphorylation required for cortical neuron migration and cell body translocation. Phenotypes partially rescued by expression of dominant negative RhoA. +MAPKAPK5 MAPKAPK5 EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, CAMK; Protein kinase, Ser/Thr (non-receptor); Tumor suppressor Q8IW41 8550 12q24.12-q24.13 human S386-p 1876193502 HENGAEDsNVALEKL enzymatic activity, induced 35064619 1 1 0 +TRIM28 TIF1B EC 6.3.2.-; KINASE; Kinase, protein; Ligase; Nuclear receptor co-regulator; Protein kinase, atypical; SUMO LIGASE; SUMO ligase; Transcription, coactivator/corepressor; UBIQUITIN LIGASE; Ubiquitin conjugating system; Ubiquitin ligase Q13263 10155 19q13.43 human S473-p 452391 SGVKRSRsGEGEVSG activity, induced; molecular association, regulation; intracellular localization cell cycle regulation; carcinogenesis, induced; carcinogenesis, inhibited; transcription, induced; signaling pathway regulation; DNA repair, induced; chromatin organization, altered; cell growth, induced NFkB-p65(DISRUPTS); SUV39H1(INDUCES); HP1 alpha(DISRUPTS); MCM3(INDUCES); PCNA(INDUCES); CTIF(INDUCES); MCM6(INDUCES); TRIM24(DISRUPTS) DNA(DISRUPTS) 22205726; 22491012; 22715096; 23645696; 23740979; 24711418; 26158765; 28864417; 29955894; 30323812; 33783327; 34419074; 34518220; 34689152; 35533307 27 117 20 +GJA8 GJA8 Channel, misc.; Membrane protein, integral; Membrane protein, multi-pass P48165 2703 1q21.2 human S259-p 2574909 LHSIAVSsIQKAKGY protein stabilization; intracellular localization 35120923 1 2 0 +Irf1 IRF1 Transcription factor; Tumor suppressor P15314 16362 11 B1.3|11 32.0 cM mouse S185-p 1380568701 RDITPALsPCVVSSS protein degradation; molecular association, regulation; ubiquitination cell growth, inhibited; transcription, induced FBXW7(INDUCES) 30854564 1 0 0 de-stabilization of chromatin-associated IRF1; induced expression of TRAIL, OAS3, PSMA6, and TBC1D32; RNA-Pol-II elongation; anti-proliferative activity in cancer cells +RUFY1 RUFY1 Ubiquitin conjugating system Q96T51 80230 5q35.3 human Y389-p 451277 TKVELETyKQTRQGL intracellular localization 11877430 1 0 2 +G6PD G6PD iso3 Carbohydrate Metabolism - pentose phosphate pathway; Cell development/differentiation; EC 1.1.1.49; Other Amino Acids Metabolism - glutathione; Oxidoreductase P11413-3 2539 Xq28 human S210-p 15207801 FGRDLQSsDRLSNHI G6PD_N enzymatic activity, induced 20649491 1 0 0 +Ptpn11 SHP-2 EC 3.1.3.48; Motility/polarity/chemotaxis; PHOSPHATASE; Protein phosphatase, tyrosine (non-receptor) P41499 25622 12q16 rat Y542-p 448492 SKRKGHEyTNIKYSL molecular association, regulation; intracellular localization; enzymatic activity, induced; phosphorylation neural plasticity caveolin-1(INDUCES) 25672415; 28768764; 35439551 38 25 442 +Pparg PPAR-gamma iso2 DNA-binding; Nuclear receptor; Transcription factor P37238-2 19016 6 E3|6 53.41 cM mouse K77-sm 3617602 QEYQSAIkVEPASPP PPARgamma_N molecular association, regulation; activity, inhibited transcription, inhibited HDAC3(INDUCES); N-CoR1(INDUCES) 16127449; 23826177 15 0 0 +ERBB2 HER2 EC 2.7.10.1; KINASE; Kinase, protein; Membrane protein, integral; Oncoprotein; Protein kinase, TK; Protein kinase, tyrosine (receptor) P04626 2064 17q12 human Y1221-p 449744 SPAFDNLyYWDQDPP enzymatic activity, induced carcinogenesis, induced; apoptosis, inhibited; cell motility, altered; cell growth, altered 18332126; 19525980; 20498373; 35864174; 37324940 34 1 14 +Cryab CRYAB Chaperone; Heat shock protein P23928 25420 8q23 rat T170-gl 5281706 REEKPAVtAAPKK__ protein degradation; molecular association, regulation; intracellular localization; phosphorylation HSP27(INDUCES) 23543138; 8639509 4 4 0 +Ybx1 YB-1 RNA processing; RNA splicing; RNA-binding; Transcription factor P62960 22608 4|4 D2.1 mouse S100-p 455636 NPRKYLRsVGDGETV CSD protein degradation; molecular association, regulation; ubiquitination OTUB1(DISRUPTS) 35490780 23 33 2 +Il6st gp130 Membrane protein, integral; Receptor, cytokine Q00560 16195 13 D2.2|13 63.73 cM mouse Y904-p 448182 DEEIPKSyLPQTVRQ transcription, altered; signaling pathway regulation 36947594 3 4 16 regulates Src and MAPK/ERK signaling +Smurf2 SMURF2 EC 6.3.2.-; EC 6.3.2.19; Ligase; UBIQUITIN LIGASE; Ubiquitin conjugating system; Ubiquitin ligase A2A5Z6 66313 11|11 E1 mouse T249-p 27457334 MSRTHLHtPPDLPEG enzymatic activity, induced cell differentiation, inhibited; transcription, inhibited; signaling pathway regulation 35304894 2 2 0 inhibits Smad1/5/8-dependent signaling +Nrip1 RIP140 Nuclear receptor co-regulator; Transcription, coactivator/corepressor Q8CBD1 268903 16|16 C3.1 mouse R240-m1 2363402 EPLSCAArLQAVASM NRIP1_repr_1 transcription, induced 19216533 2 2 0 +AKAP12 AKAP12 Adaptor/scaffold Q02952 9590 6q25.1 human K531-ac 1883516301 GLKKLSGkKQKGKRG protein degradation; ubiquitination 36122629 1 1 0 deacetylation K531 by HDAC6 facilitates its ubiquitination and degradation +MALT1 MALT1 Adaptor/scaffold; Apoptosis; EC 3.4.22.-; Ligase; Nuclear export; Protease; UBIQUITIN LIGASE; Ubiquitin conjugating system Q9UDY8 10892 18q21.32 human K824-ub 2134710 DRLRISEk_______ protein degradation; molecular association, regulation IKKA(INDUCES) 17948050 1 0 0 activation of NF-kB pathway and IL-2 induction +NEDD4L NEDD4L EC 6.3.2.-; EC 6.3.2.19; Ligase; UBIQUITIN LIGASE; Ubiquitin conjugating system; Ubiquitin ligase Q96PU5 23327 18q21.31 human S428-p 487434 AEDGASGsATNSNNH activity, inhibited 17715136 1 0 0 Phosphorylation of S342 and S428 (more important site) inhibits Nedd4L which regulates ENaC activity. +TP53 p53 Activator; DNA-binding; Motility/polarity/chemotaxis; Nuclear receptor co-regulator; Transcription factor; Tumor suppressor P04637 7157 17p13.1 human T155-p 455908 DSTPPPGtRVRAMAI P53 protein degradation; molecular association, regulation; ubiquitination cell cycle regulation; carcinogenesis, induced; cell growth, induced; cell growth, inhibited; apoptosis, induced; transcription, induced MDM2(INDUCES); FBXO42(INDUCES) 11285227; 12628923; 16964247; 21127074; 33745968 5 0 1 +NUMA1 NuMA-1 Cell cycle regulation; Motility/polarity/chemotaxis Q14980 4926 11q13.4 human T2084-p 31033005 SPNTRSGtRRSPRIA cell growth, induced; apoptosis, inhibited 23097092 1 1 0 cell proliferation increased +PRMT3 PRMT3 C2H2-type zinc finger protein; EC 2.1.1.-; METHYLTRANSFERASE; Methyltransferase; Methyltransferase, protein arginine O60678 10196 11p15.1 human Y87-p 17489700 HKHGLEFyGYIKLIN molecular association, regulation; enzymatic activity, inhibited RPS2(INDUCES) 21059412 1 0 0 +CHAT CHAT iso3 ACETYLTRANSFERASE; Acetyltransferase; EC 2.3.1.6; Lipid Metabolism - glycerophospholipid P28329-3 1103 10q11.23 human S346-p 454035 LLKHVTQsSRKLIRA Carn_acyltransf enzymatic activity, induced 15381704 1 0 0 +SRARP C1orf64 Q8NEQ6 149563 1p36.13 human T152-p 125108504 VRSSTWGtVKDSLKA C1ORF64 molecular association, regulation 14-3-3 beta(INDUCES); 14-3-3 zeta(INDUCES) 28571002; 28915724 2 0 0 +PIP5K1C PIP5K1C Carbohydrate Metabolism - inositol phosphate; EC 2.7.1.68; Kinase, lipid; Motility/polarity/chemotaxis O60331 23396 19p13.3 human S555-p 1855423 RYRRRTQsSGQDGRP protein degradation; molecular association, regulation; intracellular localization cell motility, induced; cell adhesion, induced; cytoskeletal reorganization talin 1(DISRUPTS) 26149501; 27780861 2 15 22 localizing to focal adhesions, indispensable for breast cancer cell invasion; downregulates formations of stress fibers, promotes FA turnover rates +MDC1 MDC1 Cell cycle regulation Q14676 9656 6p21.33 human S376-p 477758 LQESQAGsDTDVEEG molecular association, regulation cell cycle regulation NBS1(INDUCES) 18678890 1 26 27 MDC1-NBS1 interaction regulates intra-S-phase checkpoint activation +GFI1 GFI1 C2H2-type zinc finger protein; Cell cycle regulation; Cell development/differentiation; Transcription factor Q99684 2672 1p22.1 human S98-p 1868711303 RPPSPSAsPASEKSM protein degradation; molecular association, regulation; ubiquitination carcinogenesis, altered; signaling pathway regulation FBXW7(INDUCES) 31289136 1 1 0 +CFTR CFTR Channel, chloride; EC 3.6.3.49; Hydrolase; Membrane protein, integral; Membrane protein, multi-pass; Transporter; Transporter, ABC family P13569 1080 7q31.2 human S795-p 449982 TASTRKVsLAPQANL CFTR_R activity, induced; molecular association, regulation; enzymatic activity, inhibited; protein conformation; phosphorylation 14-3-3 beta(INDUCES); CFTR(INDUCES) 14602047; 1716180; 26888287; 32102849; 36695813 10 7 0 primes phosphorylation at S813 +APC APC Motility/polarity/chemotaxis; Tumor suppressor P25054 324 5q22.2 human S2054-p 454101 MPKKKKPsRLKGDNE intracellular localization 11050185; 11689703 2 0 0 +ATF4 ATF-4 DNA-binding; Transcription factor P18848 468 22q13.1 human S245-p 451446 TRGSPNRsLPSPGVL activity, induced carcinogenesis, induced; cell growth, altered 15109498; 22052162 3 1 0 +Smad2 SMAD2 DNA-binding; Transcription factor Q62432 17126 18 E3|18 51.42 cM mouse S245-p 448794 NQSMDTGsPAELSPT protein stabilization; molecular association, regulation; enzymatic activity, induced apoptosis, induced; transcription, induced; signaling pathway regulation 29700281 12 0 0 increase MELK stability and activity; regulate ASK1/TGF-beta/p53 signaling pathways +Efnb3 EFNB3 Cell development/differentiation; Ligand, receptor tyrosine kinase; Membrane protein, integral G3V7D4-1 360546 10q24 rat S332-p 27722391 VQDGPPQsPPNIYYK protein stabilization; molecular association, regulation; intracellular localization PSD-95(DISRUPTS) 26479588 1 1 0 reduces synaptic localization +Acadl ACADL EC 1.3.8.8; Lipid Metabolism - fatty acid; Mitochondrial; Oxidoreductase P51174 11363 1 C3|1 33.64 cM mouse K318-ac 1204118 RNYVKQRkAFGKTVA Acyl-CoA_dh_1 protein conformation; enzymatic activity, induced 24121500 1 2 1 +SIAH2 SIAH2 EC 6.3.2.-; EC 6.3.2.19; Ligase; Transcription, coactivator/corepressor; UBIQUITIN LIGASE; Ubiquitin conjugating system; Ubiquitin ligase O43255 6478 3q25.1 human S16-p 26371003 PSANKPCsKQPPPQP protein degradation; intracellular localization; enzymatic activity, induced cytoskeletal reorganization 22878263; 23044042 2 2 0 +SWAP70 SWAP-70 GEF; GEF, Rac/Rho Q9UH65 23075 11p15.4 human Y426-p 23149858 VRELEDMyLKLQEAL molecular association, regulation; intracellular localization cytoskeletal reorganization ACTN1 iso2(DISRUPTS); SWAP-70(DISRUPTS) 31932501 1 0 1 +FSCN1 fascin Actin-binding; Cytoskeletal; Motility/polarity/chemotaxis Q16658 6624 7p22.1 human K399-ub 8104831 HGFIGCRkVTGTLDA Fascin cytoskeletal reorganization 27879315 1 4 5 fascin bundling activity +BCL10 Bcl-10 Apoptosis; Transcription, coactivator/corepressor; Tumor suppressor O95999 8915 1p22.3 human S141-p 4786673 SRSNSDEsNFSEKLR activity, induced 21199863 1 2 2 +PTK2B Pyk2 EC 2.7.10.2; KINASE; Kinase, protein; Nuclear receptor co-regulator; Protein kinase, TK; Protein kinase, tyrosine (non-receptor) Q14289 2185 8p21.2 human Y402-p 447955 CSIESDIyAEIPDET protein degradation; molecular association, regulation; ubiquitination; intracellular localization; phosphorylation; enzymatic activity, induced cell cycle regulation; cell motility, altered; signaling pathway regulation RASA1(INDUCES); SOCS2(INDUCES); Src(INDUCES); HER2(INDUCES) 10713673; 10867021; 15070849; 15105428; 15778498; 16760434; 19919693; 20543098; 22802128; 25090023; 29133485; 32792487 86 2 22 activation of Src, Pyk2-mediated phosphorylation of Nox5 +ERBB3 HER3 EC 2.7.10.1; KINASE; Kinase, protein; Membrane protein, integral; Oncoprotein; Protein kinase, TK; Protein kinase, tyrosine (receptor) P21860 2065 12q13.2 human Y1054-p 449859 LLSPSSGyMPMNQGN molecular association, regulation carcinogenesis, induced; cell motility, induced PIK3R2(INDUCES); PIK3R1(INDUCES) 16729043; 21725367 3 2 20 chemotaxis and invasion +Dzip1 DZIP1 C2H2-type zinc finger protein Q8BMD2 66573 14|14 E4 mouse S664-p 13907508 STKTPPFsSEEEPDE transcription, induced; signaling pathway regulation 21878643 1 0 0 involved in Gli1 nad Gli3 turnover pathway +TRPC3 TRPC3 Channel, cation; Membrane protein, integral; Membrane protein, multi-pass Q13507 7222 4q27 human S336-p 458336 KNDYRKLsMQCKDFV activity, inhibited 14983059; 16331690 2 0 0 +Styk1 STYK1 EC 2.7.10.2; KINASE; Kinase, protein; Membrane protein, integral; Oncoprotein; Protein kinase, TK; Protein kinase, tyrosine (non-receptor); Protein kinase, tyrosine (receptor) Q6J9G1 243659 6|6 F3 mouse Y363-p 458345 SSCSHAMyNIMKCCW PK_Tyr_Ser-Thr apoptosis, inhibited; cell growth, altered 16322230 1 0 0 mutation of this site promotes cellular apoptosis +Myo3a MYO3A Actin-binding; EC 2.7.11.1; KINASE; Kinase, protein; Motor; Protein kinase, STE; Protein kinase, Ser/Thr (non-receptor) Q8K3H5 667663 2|2 A3 mouse S313-p 36841904 DIHQCLGsTEKARHE enzymatic activity, induced 21895655 1 1 0 +Crem CREM DNA-binding; Transcription factor P27699 12916 18|18 A1 mouse S156-p 450064 PKIEEEKsEEEGTPP activity, inhibited transcription, altered 8114763 2 0 0 +KIR2DL1 KIR2DL1 Membrane protein, integral; Receptor, misc. P43626 3802 19q13.42 human Y302-p 462345 QDPQEVTyTQLNHCV molecular association, regulation signaling pathway regulation supervillin(INDUCES) 21070852 1 2 1 supervillin is required for KIR2DL1-mediated inhibition of Vav1 and Erk phosphorylation +ETV5 ERM DNA-binding; Transcription factor P41161 2119 3q27.2 human K350-sm 2887211 ERLEGKVkQEPTMYR ETS_PEA3_N transcription, inhibited 15857832; 18243147 2 1 0 +BIRC5 Survivin Apoptosis O15392 332 17q25.3 human K91-ub 40439804 CAFLSVKkQFEELTL protein degradation 25778398 1 2 0 impairs mitochondrial function +ESR2 ER-beta DNA-binding; Nuclear receptor Q92731 2100 14q23.2-q23.3 human S105-p 447914 LYAEPQKsPWCEARS ERbeta_N activity, induced; intracellular localization 15862947; 20696772 5 1 0 expressed in nucleus and as nuclear speckles +PKN2 PKN2 EC 2.7.11.13; KINASE; Kinase, protein; Protein kinase, AGC; Protein kinase, Ser/Thr (non-receptor) Q16513 5586 1p22.2 human S815-p 4754738 MGYGDRTsTFCGTPE Pkinase enzymatic activity, induced 19723632 1 3 37 +Was WASP Adaptor/scaffold; Motility/polarity/chemotaxis P70315 22376 X A1.1|X 3.65 cM mouse S502-p 449295 RSRVIHSsDEGEDQT activity, induced cytoskeletal reorganization 24223520 2 11 0 +Tfeb TFEB DNA-binding; Transcription factor Q9R210 21425 17 C|17 23.99 cM mouse S400-p 1880515602 LDFSHGLsFGGGGDE intracellular localization cell differentiation, induced; transcription, induced 36507874 1 0 0 +Mybpc3 MYBPC3 Myosin-binding P56741 295929 3q24 rat S288-p 471080 AGTGRRTsDSHEDAG molecular association, regulation cytoskeletal reorganization TNNI3(DISRUPTS) 35288601; 36470422 35 8 28 +Rptor Raptor Adaptor/scaffold Q8K4Q0 74370 11|11 E2 mouse S877-p 3205938 HMHQVGGsPPASSTS enzymatic activity, inhibited 31530866 8 54 0 suppresses mTORC1 activity +E2F1 E2F1 DNA-binding; Transcription factor Q01094 1869 20q11.22 human S337-p 447869 IVSPPPSsPPSSLTT molecular association, regulation; intracellular localization; protein conformation cell cycle regulation; transcription, induced; transcription, altered; cell growth, altered PRB1(INDUCES); Rb(DISRUPTS); E4(INDUCES) DNA(INDUCES) 20616879; 26724859; 27935805; 29264472; 35678423; 8087847 9 1 0 +CLDN6 Claudin-6 Cell adhesion; Membrane protein, integral; Membrane protein, multi-pass P56747 9074 16p13.3 human Y200-p 7792487 PSHYMARySTSAPAI cell adhesion, altered; signaling pathway regulation 31740618 1 2 17 +PPP1R3F PPP1R3F Membrane protein, integral; Protein phosphatase, regulatory subunit Q6ZSY5 89801 Xp11.23 human S401-p 22650303 EGDVPRSsPPVAFTE signaling pathway regulation 21668450 0 1 0 regulation of glycogen synthesis via R3F-PP1 signaling in astrocytoma cells +Vamp4 VAMP4 Membrane protein, integral; Vesicle O70480 53330 1 H2.1|1 70.29 cM mouse S30-p 454285 RNLLEDDsDEEEDFF molecular association, regulation; intracellular localization PACS-1(INDUCES) 14608369 1 75 10 +ATF7 ATF7 C2H2-type zinc finger protein; DNA-binding; Transcription factor P17544 11016 12q13.13 human K107-sm 4617200 STPDIKIkEEEPVEV intracellular localization transcription, inhibited 17264123; 18950637 2 0 0 +Trpv2 TRPV2 Channel, cation; Membrane protein, integral; Membrane protein, multi-pass Q9WUD2 29465 10q23 rat S760-p 7103644 LPLQVLQsP______ cell growth, induced 26416880 1 6 0 neurite outgrowth +Aatf AATF Nucleolus; RNA-binding; Transcription factor Q9JKX4 56321 11|11 C mouse S316-p 1868281680 LEMEDYPsFMAKRFA AATF-Che1 acetylation chromatin organization, altered; cell growth, induced; transcription, induced H3(INDUCES) 34266450 1 2 0 induces histone acetylation +RHO Rhodopsin GPCR, family 1; Membrane protein, integral; Membrane protein, multi-pass; Receptor, GPCR P02699 509933 cow S338-p 448679 DEASTTVsKTETSQV molecular association, regulation; protein conformation SAG(INDUCES) 15041682 8 7 0 Computational and in vitro data. S343 may be a weaker interaction. +GATA2 GATA2 Transcription factor P23769 2624 3q21.3 human T176-p 40245500 HLFGFPPtPPKEVSP protein degradation; molecular association, regulation FBXW7(INDUCES) 25670854 1 1 0 +Hk2 HK2 Carbohydrate Metabolism - amino sugar and nucleotide sugar; Carbohydrate Metabolism - fructose and mannose; Carbohydrate Metabolism - galactose; Carbohydrate Metabolism - glycolysis and gluconeogenesis; Carbohydrate Metabolism - starch and sucrose; EC 2.7.1.1; Kinase, other; Mitochondrial O08528 15277 6 C3|6 35.94 cM mouse T473-p 28704601 QHRARQKtLESLKLS Hexokinase_1 intracellular localization; enzymatic activity, induced carcinogenesis, induced; cell motility, induced; chromatin organization, altered; apoptosis, inhibited 23836898; 23852728; 30877036 6 0 0 mitochondria-associated ER membrane integrity; increase lactic acid production; regulate NF-kB/HIF1a/MMP2/MMP9 expressions; protects against oxidative stress increasing cell viability +Pde3a PDE3A EC 3.1.4.17; Membrane protein, integral; Membrane protein, multi-pass; Nucleotide Metabolism - purine; Phosphodiesterase Q9Z0X4 54611 6|6 G2 mouse S292-p 471417 KRRRRSSsVVAGEMS enzymatic activity, induced 17124499 1 2 10 activated during oocytes maturation in mouse treated with hCG ; required for insulin-dependent Xenopus oocyte maturation +PSIP1 LEDGF Motility/polarity/chemotaxis; Transcription, coactivator/corepressor O75475 11168 9p22.3 human S206-p 7231784 MVKQPCPsESDIITE phosphorylation 19864417 1 12 0 stimulates phosphorylation of MCM2 at S53 +PIKFYVE PIKFYVE Carbohydrate Metabolism - inositol phosphate; EC 2.7.1.150; KINASE; Kinase, lipid; Motility/polarity/chemotaxis; Protein kinase, Ser/Thr (non-receptor) Q9Y2I7 200576 2q34 human S318-p 3216759 LSLDRSGsPMVPSYE activity, induced; enzymatic activity, induced carcinogenesis, inhibited; cell motility, inhibited; signaling pathway regulation 19232516; 23188060; 23757022; 30445978 4 3 7 Increased Kir2.1 mediated current; induce activation of chloride channel CLCN2; dephosphorylation of PIKFYVE leads to activated EGFR signaling; induces EGFR degradation and regulates EGFR phosphorylation +AR AR DNA-binding; Nuclear receptor; Transcription factor P10275 367 Xq12 human T282-p 15605002 VPPAVRPtPCAPLAE Androgen_recep activity, induced; molecular association, regulation transcription, altered; cell growth, altered DNA(NOT_REPORTED) 20713353 1 0 0 +KEAP1 KEAP1 Endoplasmic reticulum; Motility/polarity/chemotaxis; Transcription regulation; UBIQUITIN LIGASE; Ubiquitin conjugating system Q14145 9817 19p13.2 human K312-ac 1883300103 FEELTLHkPTQVMPC protein stabilization; molecular association, regulation transcription, inhibited Tau(INDUCES) 35917404 1 0 0 hP301S mutant Tau, decreases the transcription of synaptic genes in the presence of P301S mutant, synapse loss and cognitive dysfunction +SQSTM1 SQSTM1 Autophagy; Nuclear receptor co-regulator; Ubiquitin conjugating system Q13501 8878 5q35.3 human K295-ac 1881279900 SCCSDPSkPGGNVEG protein degradation carcinogenesis, inhibited 33854041 1 1 0 Sirt1 stabilizes SQSTM1 by inhibiting its acetylation, suppressing its ubiquitylation. +Flt3 FLT3 EC 2.7.10.1; KINASE; Kinase, protein; Membrane protein, integral; Oncoprotein; Protein kinase, TK; Protein kinase, tyrosine (receptor) Q00342 14255 5 86.88 cM|5 G3 mouse Y892-p 456469 FSLGVNPyPGIPVDA PK_Tyr_Ser-Thr protein stabilization; enzymatic activity, induced 16091740 1 0 0 +Tagln TAGLN Actin-binding; Motility/polarity/chemotaxis; Nuclear receptor co-regulator P31232 25123 8q22 rat K21-ub 49199201 VQSKIEKkYDEELEE molecular association, regulation G6PD(INDUCES) 26291555 1 0 0 +ERBB2 HER2 EC 2.7.10.1; KINASE; Kinase, protein; Membrane protein, integral; Oncoprotein; Protein kinase, TK; Protein kinase, tyrosine (receptor) P04626 2064 17q12 human Y1139-p 448678 TCSPQPEyVNQPDVR molecular association, regulation cell motility, altered; cell adhesion, altered; transcription, induced; signaling pathway regulation; cell growth, altered GRB2(INDUCES); Src(INDUCES); GRB7(INDUCES); JAK2(NOT_REPORTED) 11238891; 11940572; 12551896; 16729043; 18332126; 9516479 11 5 46 +HDAC2 HDAC2 DEACETYLASE; Deacetylase; EC 3.5.1.98; Nuclear receptor co-regulator; Transcription, coactivator/corepressor Q92769 3066 6q21 human Y222-p 464957 IGAGKGKyYAVNFPM Hist_deacetyl protein stabilization; ubiquitination transcription, inhibited 25219501 1 0 2 inhibits polyubiquitination +MRE11 MRE11A Cell cycle regulation; DNA repair, damage; DNA-binding; Deoxyribonuclease P49959 4361 11q21 human R594-m2 62978407 RGGSQRGrADTGLET DNA repair, altered 15741314 0 1 0 +CHEK2 Chk2 EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, CAMK; Protein kinase, Ser/Thr (non-receptor); Tumor suppressor O96017 11200 22q12.1 human T26-p 447547 SQPHGSVtQSQGSSS phosphorylation; enzymatic activity, induced 12024051 3 1 0 +MYLK smMLCK EC 2.7.11.18; KINASE; Kinase, protein; Protein kinase, CAMK; Protein kinase, Ser/Thr (non-receptor) Q15746 4638 3q21.1 human Y471-p 451415 YEDAGSHyLCLLKAR I-set molecular association, regulation; enzymatic activity, induced Cortactin(INDUCES) 11113114; 12408982 2 1 5 +Trim28 TIF1B EC 6.3.2.-; KINASE; Kinase, protein; Ligase; Nuclear receptor co-regulator; Protein kinase, atypical; SUMO LIGASE; SUMO ligase; Transcription, coactivator/corepressor; UBIQUITIN LIGASE; Ubiquitin conjugating system; Ubiquitin ligase Q62318 21849 7|7 A1 mouse K779-sm 2798309 FNKLTEDkADVQSII transcription, inhibited 17298944 6 8 0 +ARAF ARAF EC 2.7.11.1; KINASE; Kinase, protein; Oncoprotein; Protein kinase, Ser/Thr (non-receptor); Protein kinase, TKL P10398 369 Xp11.3 human Y301-p 455521 LGYRDSGyYWEVPPS activity, induced 9020159 1 2 9 +Itpr1 IP3R1 Channel, calcium; Channel, ligand-gated; Membrane protein, integral; Membrane protein, multi-pass P11881 16438 6 E1|6 49.74 cM mouse S1755-p 450682 RPSGRREsLTSFGNG activity, induced; phosphorylation transcription, induced; signaling pathway regulation 17257671; 22495310; 34905386 13 24 15 induces phosphorylation of CAMK2 and downstream targets; induce calcineurin activation, CRTC2 dephosphorylation and activation IP3R1 and gluconeogenesis.; Ca(2+) mobilization +JUND JunD Motility/polarity/chemotaxis; Transcription factor P17535 3727 19p13.11 human T71-p 23117102 PAAAPPPtPLRADGA Jun molecular association, regulation carcinogenesis, induced; transcription, induced PPP1R13B(DISRUPTS) 36261000 1 1 1 +ROBO1 ROBO1 Cell adhesion; Membrane protein, integral; Motility/polarity/chemotaxis Q9Y6N7 6091 3p12.3 human Y1073-p 465118 PSGQPTPyATTQLIQ activity, inhibited 10892742 1 3 5 +Plcg2 PLCG2 Carbohydrate Metabolism - inositol phosphate; EC 3.1.4.11; Motility/polarity/chemotaxis; Phospholipase P24135 29337 19q12 rat Y759-p 447941 LYDVSRMyVDPSEIN enzymatic activity, induced 11507089 21 13 227 +TEAD4 TEAD4 DNA-binding; Transcription factor Q15561 7004 12p13.33 human S322-p 451164 GVSSQYEsPENMIIT YBD activity, induced 10764782 1 0 0 Mutation of S315 to alanine reduced alpha1-adrenergic activation of TEF-3. +JUN Jun Oncoprotein; Transcription factor P05412 3725 1p32.1 human T89-p 17737602 QSSNGHItTTPTPTQ Jun carcinogenesis, altered; cell growth, altered 21177766 1 0 0 +CREB3L3 CREB3L3 Membrane protein, integral; Transcription factor Q68CJ9 84699 19p13.3 human K294-ac 15293936 RKVLHLEkQNLSLLE bZIP_1 activity, induced; molecular association, regulation; protein processing transcription, induced PPAR-alpha(INDUCES) 26438600; 28461393 3 0 1 hepatic glycogenolysis and gluconeogenesis; PCK1 and PYGL transcription. Maintains glucose homeostasis +NDC80 HEC1 Cell cycle regulation O14777 10403 18p11.32 human S69-p 474513 SGHGSRNsQLGIFSS Ndc80_HEC cell cycle regulation; cytoskeletal reorganization 17129782; 29187526; 35878017; 36897279 6 17 17 +ESR1 ER-alpha DNA-binding; Nuclear receptor; Transcription factor P03372 2099 6q25.1-q25.2 human R260-m2 34490425 GGIRKDRrGGRMLKH molecular association, regulation cell cycle regulation Src(INDUCES); PIK3R1(INDUCES) 18657504 1 0 0 occurring in the cytoplasm of normal and tumor epithelial breast cells in humans +RUNX2 AML3 DNA-binding; Transcription factor Q13950 860 6p21.1 human S28-p 3053615 PSTSRRFsPPSSSLQ transcription, altered 19264160 8 14 1 +Hnrnpa1 hnRNP A1 Nuclear export; RNA splicing; RNA-binding; Spliceosome P04256 29578 7q36 rat S192-p 456539 EMASASSsQRGRSGS activity, inhibited 7727389 2 0 0 +CDH1 CDH1 Cell adhesion; Membrane protein, integral; Motility/polarity/chemotaxis; UBIQUITIN LIGASE; Ubiquitin ligase P12830 999 16q22.1 human S847-p 465568 SEAASLSsLNSSESD CADH_Y-type_LIR protein stabilization carcinogenesis, altered; cell motility, inhibited 35115926 4 0 0 +Yy1 YY1 C2H2-type zinc finger protein; Cell development/differentiation; Transcription factor Q00899 22632 12 F1|12 59.58 cM mouse S184-p 476106 GKKSGKKsYLGGGAG molecular association, regulation RNA(DISRUPTS) 28834756 2 3 1 +OCLN occludin Cell adhesion; Membrane protein, integral; Membrane protein, multi-pass; Motility/polarity/chemotaxis Q16625 100506658 5q13.2 human T403-p 471471 DHYETDYtTGGESCD intracellular localization 19114660 2 2 4 +Pak5 PAK5 EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, STE; Protein kinase, Ser/Thr (non-receptor) Q8C015 241656 2|2 F3 mouse S602-p 447773 KEVPKRKsLVGTPYW Pkinase cell growth, induced 34087103 3 13 42 +PANX1 PANX1 Cell adhesion; Membrane protein, integral; Membrane protein, multi-pass Q96RD7 24145 11q21 human Y150-p 4113671 MEELDKVyNRAIKAA Innexin intracellular localization 33405952 1 1 1 +Irs1 IRS1 Adaptor/scaffold; Motility/polarity/chemotaxis P35570 25467 9q34 rat S307-p 447558 TESITATsPASMVGG molecular association, regulation; phosphorylation signaling pathway regulation INSR(DISRUPTS) 11160134; 11606564; 25978724 77 14 0 +MDM2 MDM2 EC 6.3.2.-; EC 6.3.2.19; Inhibitor; Ligase; NEDDYLATION LIGASE; Neddylation Ligase; Nucleolus; Oncoprotein; UBIQUITIN LIGASE; Ubiquitin conjugating system; Ubiquitin ligase Q00987 4193 12q15 human Y276-p 465467 SDEDDEVyQVTVYQA molecular association, regulation; intracellular localization p14ARF(INDUCES) 16702947 1 1 0 contributes to Hdm2-mediated turnover of p53 +IRS1 IRS1 Adaptor/scaffold; Motility/polarity/chemotaxis P35568 3667 2q36.3 human S629-p 478346 VPSGRKGsGDYMPMS molecular association, regulation PIK3R1(INDUCES) 17640984 2 15 38 +PRKCE PKCE EC 2.7.11.13; KINASE; Kinase, protein; Protein kinase, AGC; Protein kinase, Ser/Thr (non-receptor) Q02156 5581 2p21 human S368-p 2085101 NNIRKALsFDNRGEE molecular association, regulation cell cycle regulation; transcription, altered 14-3-3 beta(INDUCES) 18458086; 18604201 3 17 0 +Stat1 STAT1 DNA-binding; Transcription factor Q9QXK0 25124 9q22 rat S727-p 447753 TENLLPMsPEEFDEM STAT1_TAZ2bind activity, induced apoptosis, induced; apoptosis, inhibited; transcription, altered 11309387; 14984365 118 32 90 +ATF2 ATF-2 ACETYLTRANSFERASE; C2H2-type zinc finger protein; EC 2.3.1.48; Transcription factor P15336 1386 2q31.1 human T52-p 23305000 HKHKHEMtLKFGPAR intracellular localization carcinogenesis, induced; cell motility, induced; cell growth, induced; apoptosis, inhibited; transcription, induced; transcription, inhibited; cell adhesion, inhibited 22304920; 26645581 2 0 1 T52 phosphorylation negatively regulates ATF-2 mitochondrial localization and basal transcriptional activity of ATF-2.; decreased FUK expression, decreased cellular protein fucosylation +HMGB1 HMGB1 DNA repair, damage; Nuclear receptor co-regulator P09429 3146 13q12.3 human K82-ac 460592 MKTYIPPkGETKKKF chromatin organization, altered 15005629 5 4 0 +FOSL1 FRA1 DNA-binding; Transcription factor P15407 8061 11q13.1 human T230-p 27259000 TPSLTPFtPSLVFTY protein stabilization 22286759 1 0 0 +Scimp UNQ5783 Membrane protein, integral Q3UU41 327957 11|11 B3 mouse Y96-p 464681 PRQPSAWySSVKKVR SCIMP molecular association, regulation transcription, induced GRB2(INDUCES); TLR4(INDUCES); CSK(INDUCES); Syk(INDUCES); TLR2(INDUCES); BLNK(INDUCES); TLR3(INDUCES); TLR1(INDUCES) 34496234; 35337798 2 0 9 +FMR1 FMR1 iso3 Nucleolus; RNA-binding; Translation Q06787-3 2332 Xq27.3 human S499-p 14323700 SDHRDELsDWSLAPT FXMRP1_C_core molecular association, regulation; intracellular localization TDP-43(DISRUPTS) 30630951 4 1 0 +MARK3 MARK3 iso3 EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, CAMK; Protein kinase, Ser/Thr (non-receptor) P27448-3 4140 14q32.32-q32.33 human S96-p 3597304 KTQLNPTsLQKLFRE Pkinase enzymatic activity, inhibited 15319445 1 0 0 +Ephb2 EphB2 EC 2.7.10.1; KINASE; Kinase, protein; Membrane protein, integral; Protein kinase, TK; Protein kinase, tyrosine (receptor); Tumor suppressor P54763 13844 4 D3|4 69.0 cM mouse Y596-p 448326 MTPGMKIyIDPFTYE EphA2_TM molecular association, regulation; enzymatic activity, induced cytoskeletal reorganization; cell adhesion, altered NMDAR1(INDUCES); RASA1(INDUCES); Src iso1(INDUCES) 10644995; 10848605; 11136979; 16977320 6 18 117 in vitro +Pfn1 profilin 1 Actin-binding; Cytoskeletal; Motility/polarity/chemotaxis P62962 18643 11 B3|11 43.21 cM mouse Y129-p 450514 GLINKKCyEMASHLR Profilin activity, induced cytoskeletal reorganization 28743718 4 25 658 higher activity of profilin-1 in Twf2a-/- platelets +Nf2 Merlin Cytoskeletal; Motility/polarity/chemotaxis; Tumor suppressor P46662 18016 11 A1|11 3.0 cM mouse S10-p 1720901 GAIASRMsFSSLKRK protein degradation; protein stabilization cytoskeletal reorganization 33414453 5 10 0 induces MDM2 stabilization and PSD95 degradation +PARP1 PARP1 DNA repair, damage; EC 2.4.2.30; Nuclear envelope; Nuclear receptor co-regulator; Nucleolus; Transferase P09874 142 1q42.12 human K486-sm 9859928 SPWGAEVkAEPVEVV ADP-ribosylation; protein degradation; molecular association, regulation; acetylation; ubiquitination transcription, induced; transcription, inhibited p300(DISRUPTS); RNF4(INDUCES) 19622798; 19779455; 20228053 3 6 0 +ILK ILK EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, Ser/Thr (non-receptor); Protein kinase, TKL Q13418 3611 11p15.4 human T181-p 6191018 RTRPRNGtLNKHSGI signaling pathway regulation 22521536 1 16 18 PKCA-ILK signaling pathway for growth cone collapse, RGC axon guidance, repulsive axon turning induced by Shh +GPI G6PI Apoptosis; Carbohydrate Metabolism - amino sugar and nucleotide sugar; Carbohydrate Metabolism - glycolysis and gluconeogenesis; Carbohydrate Metabolism - pentose phosphate pathway; Carbohydrate Metabolism - starch and sucrose; Cytokine; EC 5.3.1.9; Isomerase P06744 2821 19q13.11 human S185-p 455279 GPRVWYVsNIDGTHI PGI molecular association, regulation; enzymatic activity, inhibited cell growth, altered G6PI(INDUCES) 15637053 2 0 0 +Tuba1a TUBA1A Cytoskeletal; Motility/polarity/chemotaxis P68369 22142 15 F1|15 55.29 cM mouse K40-ac 460619 DGQMPSDkTIGGGDD Tubulin protein stabilization; acetylation; intracellular localization cell cycle regulation; autophagy, induced; cell motility, induced; cell motility, inhibited; cytoskeletal reorganization 22972992; 31018989; 31498540; 32697819; 32885602; 33195286; 35486479 71 7 11 knockdown of RASSF1A impairs spindle organization and chromosome alignment +FLNA FLNA Actin-binding; Motility/polarity/chemotaxis; Nuclear receptor co-regulator P21333 2316 Xq28 human S1459-p 452266 KCSGPGLsPGMVRAN Filamin molecular association, regulation cell motility, induced; cell motility, altered; cytoskeletal reorganization CCND1(DISRUPTS) 20179208; 25445790 2 71 16 cell separation following mitosis, AAA mutant has defects in cell motility +RNF20 RNF20 EC 6.3.2.-; EC 6.3.2.19; Ligase; UBIQUITIN LIGASE; Ubiquitin conjugating system; Ubiquitin ligase Q5VTR2 56254 9q31.1 human S172-p 18710200 SSSEEMEsQLQERVE ubiquitination DNA repair, induced 21362549 1 0 0 induces H2B-K125 ubiquitylation +Scn2a SCN2A Channel, sodium; Membrane protein, integral; Membrane protein, multi-pass P04775 24766 3q21 rat Y730-p 1152200 QKCPPCWyKFANMCL activity, inhibited 17959797 1 0 0 +GRB7 GRB7 Adaptor/scaffold; Motility/polarity/chemotaxis Q14451 2886 17q12 human Y188-p 7965100 FRKNFAKyELFKSSP phosphorylation cell cycle regulation; cell motility, altered 19473962 1 0 1 double mutation Grb7 Y188, 338F inhibits phosphorylation of FAK Y397 (Y428 in mouse), Y861 (Y899 in mouse) and PXN Y118; involed in tumorigenesis process +APP APP Apoptosis; Cell surface; Membrane protein, integral; Receptor, misc.; Transcription factor P05067 351 21q21.3 human K763-ne 12124801 GYENPTYkFFEQMQN APP_amyloid transcription, inhibited Fe65(DISRUPTS) 18096514 1 0 0 +DAPK1 DAPK1 Apoptosis; Autophagy; EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, CAMK; Protein kinase, Ser/Thr (non-receptor) P53355 1612 9q21.33 human S734-p 454887 NSSRFPPsPLASKPT enzymatic activity, induced apoptosis, altered; apoptosis, induced; cell adhesion, inhibited 15616583; 26769850 2 0 7 anoikis function of DAPK +MCM2 MCM2 DNA-binding; EC 3.6.4.12 P49736 4171 3q21.3 human S53-p 473058 LPPFEDEsEGLLGTE MCM2_N molecular association, regulation; enzymatic activity, induced cell cycle regulation; carcinogenesis, induced; chromatin organization, altered; apoptosis, inhibited; cell growth, altered DNA(INDUCES) 16446360; 17062569; 25412417; 25843623; 26921250; 28273463; 31578521 16 9 16 loss of CDC7 induce senescence in liver cancer cells +Erbb2 HER2 EC 2.7.10.1; KINASE; Kinase, protein; Membrane protein, integral; Oncoprotein; Protein kinase, TK; Protein kinase, tyrosine (receptor) P06494 24337 10q31 rat Y1141-p 448678 ACSPQPEyVNQSEVQ molecular association, regulation GRB2(INDUCES) 11500516 11 5 46 This site can mediate transforming signals. +Tuba1a TUBA1A Cytoskeletal; Motility/polarity/chemotaxis P68370 64158 7q36 rat K40-ac 460619 DGQMPSDkTIGGGDD Tubulin acetylation; protein stabilization; intracellular localization 34548475; 35486479 71 7 11 K40 acetylation decreases GLUT4 vesicles translocation to the plasma membrane; K40 acetylation level affects glucose transport +Prkaa1 AMPKA1 Autophagy; EC 2.7.11.1; EC 2.7.11.26; EC 2.7.11.27; EC 2.7.11.31; KINASE; Kinase, protein; Protein kinase, CAMK; Protein kinase, Ser/Thr (non-receptor) Q5EG47 105787 15|15 A1 mouse S508-p 4274314 RSCQRSDsDAEAQGK enzymatic activity, inhibited; phosphorylation 24928508 2 11 17 induces phosphorylation at S496 and inhibits phosphorylation at T183 further enhancing glucose production +TGFBR1 TGFBR1 EC 2.7.11.30; KINASE; Kinase, protein; Membrane protein, integral; Protein kinase, Ser/Thr (receptor); Protein kinase, TKL; Receptor, misc. P36897 7046 9q22.33 human T204-p 4325703 VQRTIARtIVLQESI activity, induced; phosphorylation; enzymatic activity, induced cell growth, induced; transcription, induced 18625725; 29467918; 33051597; 7774578 4 0 0 Induce transcription of SBE4; Induce phosphorylation of SMAD2/3; constitutively active mutant T204D +MYH10 MYH10 Motility/polarity/chemotaxis; Motor P35580 4628 17p13.1 human S1975-p 465603 NETQPPQsE______ cytoskeletal reorganization 30087119 2 21 0 downregulates filament assembly +HSPA1A HSP70 Chaperone; Heat shock protein; Motility/polarity/chemotaxis P0DMV8 3303 6p21.33 human T66-p 31882985 VALNPQNtVFDAKRL HSP70 intracellular localization; protein conformation cell cycle regulation 30108182 2 4 0 +CD5 CD5 Cell surface; Membrane protein, integral P06127 921 11q12.2 human T436-p 450130 FHRNHTAtVRSHAEN activity, induced; receptor internalization, altered 11123317 1 0 44 +ITGAM ITGAM iso100 Cell adhesion; Membrane protein, integral; Motility/polarity/chemotaxis P11215_VAR_P1146S 3684 16p11.2 human S1146-p 60885603 DMMSEGGsPGAEPQ_ molecular association, regulation 27974454 1 0 0 PS1146 substitution generates a binding site for 14-3-3-zeta, but does not require S1146 phosphorylation. +H2AC11 H2A.1 DNA-binding P0C0S8 8329 6p22.1 human K118-ub 3945247 IQAVLLPkKTESHHK Histone_H2A_C methylation; enzymatic activity, inhibited cell cycle regulation; carcinogenesis, induced; carcinogenesis, inhibited; cell growth, inhibited; DNA repair, induced; cell growth, induced; chromatin organization, altered; transcription, inhibited 20543557; 23238014; 24019522; 24292684; 25578731; 32427989 12 14 157 Overexpressed H2A rescuing DNA replication in Mdm4-depleted WT cells, but not in K118,119R mutant cells +Gata4 GATA4 Motility/polarity/chemotaxis; Transcription factor Q08369 14463 14 D1|14 33.24 cM mouse K366-sm 3982503 SEEMRPIkTEPGLSS intracellular localization cell differentiation, altered; transcription, induced 15337742 1 0 0 +ATP7A ATP7A Apoptosis; Cell development/differentiation; Chaperone; EC 3.6.3.54; Hydrolase; Membrane protein, integral; Membrane protein, multi-pass; Transporter; Transporter, ion channel; Vesicle Q04656 538 Xq21.1 human S339-p 9768104 RKAIEAVsPGLYRVS HMA protein conformation 21258844 2 7 0 S339 alters the dynamics of domain by increasing the flexibility whereas T327 decreasing the flexibility in Cu bound MBD3 +AKT1 Akt1 EC 2.7.11.1; KINASE; Kinase, protein; Oncoprotein; Protein kinase, AGC; Protein kinase, Ser/Thr (non-receptor) P31749 207 14q32.33 human K14-ub 12723502 VKEGWLHkRGEYIKT PH ubiquitination; intracellular localization; phosphorylation; enzymatic activity, induced 19713527; 31182807 2 3 0 promotes Akt membrane recruitment and phosphorylation, resulting in activation; IL-15-stimulated phosphorylation as well as in ubiquitination with K63ub as an acceptor for polyubiquitin chain formation and AKT activation. +HRAS HRas G protein; G protein, monomeric; G protein, monomeric, Ras; Motility/polarity/chemotaxis; Oncoprotein P01112 3265 11p15.5 human Y32-p 15228776 QNHFVDEyDPTIEDS Ras activity, inhibited carcinogenesis, inhibited; signaling pathway regulation 33413561 3 4 8 inhibits MAPK signaling +Trarg1 TUSC5 Membrane protein, integral; Membrane protein, multi-pass Q8C838 237858 11|11 B5 mouse S80-p 3842521 GSPSRVSsRRASSVI intracellular localization 35594055 1 4 0 regulates GLUT4 translocation +Rbck1 RBCK1 EC 6.3.2.-; Ligase; UBIQUITIN LIGASE; Ubiquitin conjugating system; Ubiquitin ligase Q62921 rat T207-p 2103605 CTFINKPtRPGCEMC protein stabilization 18303026 2 0 0 inhibits self-ubiquitination of RBCK1 in vitro +Sirpa SHPS1 Cell adhesion; Cell surface; Membrane protein, integral; Motility/polarity/chemotaxis; Receptor, misc. P97710 25528 3q36 rat Y477-p 451114 RPEDTLTyADLDMVH molecular association, regulation SHP-2(INDUCES) 9535915 5 8 18 +EPHB4 EphB4 EC 2.7.10.1; KINASE; Kinase, protein; Membrane protein, integral; Protein kinase, TK; Protein kinase, tyrosine (receptor) P54760 2050 7q22.1 human Y596-p 450855 VYIDPFTyEDPNEAV EphA2_TM molecular association, regulation; enzymatic activity, induced cell motility, induced; cell growth, induced; cytoskeletal reorganization RASA1(INDUCES) 11929761; 16950769; 37507023 3 26 198 +CRK CRK Adaptor/scaffold; Motility/polarity/chemotaxis; Oncoprotein Q04929 417553 chicken Y240-p 450357 NLQNGPFyARVIQKR SH3_2 molecular association, regulation; protein conformation Abl(DISRUPTS) 17289588 2 5 268 +RPTOR Raptor Adaptor/scaffold Q8N122 57521 17q25.3 human T908-p 23940710 LPSGRPGtTGPAGAQ activity, induced 22356909 1 1 0 leading to mTORC1 activation +UGDH UGDH Carbohydrate Metabolism - amino sugar and nucleotide sugar; Carbohydrate Metabolism - ascorbate and aldarate; Carbohydrate Metabolism - pentose and glucuronate interconversions; Carbohydrate Metabolism - starch and sucrose; EC 1.1.1.22; Motility/polarity/chemotaxis; Oxidoreductase O60701 7358 4p14 human Y473-p 4699451 VSSKRIPyAPSGEIP molecular association, regulation carcinogenesis, induced; cell motility, induced; RNA stability, induced; transcription, induced HuR(INDUCES) Other(INDUCES); Other(DISRUPTS) 31243371; 36896759 3 4 4 induces binding to UDP-Glc and hence disrupting interaction of HUR with UDP-Glc, facilitates easy release of UDP-GlcUA +PVRIG PVRIG Membrane protein, integral; Membrane protein, multi-pass Q6DKI7 79037 7q22.1 human Y233-p 53991100 QAALHVPyATINTSC molecular association, regulation SHP-2(INDUCES); SHP-1(INDUCES) 26755705 1 0 0 +SIAH1 SIAH1 Apoptosis; Cell development/differentiation; EC 6.3.2.-; EC 6.3.2.19; Ligase; Motility/polarity/chemotaxis; UBIQUITIN LIGASE; Ubiquitin conjugating system; Ubiquitin ligase Q8IUQ4 6477 16q12.1 human S19-p 2840508 GTSKCPPsQRVPALT molecular association, regulation; ubiquitination; activity, inhibited HIPK2(DISRUPTS) 18536714 1 0 0 facilitates HIPK2 polyubiquitination +HSPA1A HSP70 Chaperone; Heat shock protein; Motility/polarity/chemotaxis P0DMV8 3303 6p21.33 human K77-ac 40663225 AKRLIGRkFGDPVVQ HSP70 protein stabilization; molecular association, regulation; ubiquitination; enzymatic activity, induced apoptosis, inhibited CHIP(DISRUPTS); HIP(INDUCES); HSP40(DISRUPTS) Other(INDUCES) 27708256 2 1 2 induces binding to ATP and ATPase activity, inhibits ubiquitination +GRB14 GRB14 Adaptor/scaffold Q14449 2888 2q24.3 human S366-p 29576856 GCSSQSIsPMRSISE molecular association, regulation; phosphorylation INSR(DISRUPTS) 24535599; 28130417 2 5 0 +CYCS CYCS Apoptosis; Mitochondrial; Oxidoreductase; PHOSPHATASE; Protein phosphatase, Ser/Thr (non-receptor) P99999 54205 7p15.3 human Y49-p 473243 GQAPGYSyTAANKNK Cytochrom_C molecular association, regulation; protein conformation; enzymatic activity, induced apoptosis, inhibited COX4I1(DISRUPTS) 21706253; 28348229 4 4 4 donate electrons to complex IV +DDX5 DDX5 EC 3.6.4.13; Helicase; Nuclear receptor co-regulator; Nucleolus; RNA splicing; RNA-binding; Spliceosome P17844 1655 17q23.3 human R478-m2 1877752102 LLQLVEDrGSGRSRG molecular association, regulation XRN2(INDUCES) 31267554 1 1 0 represses R-loops +BORA BORA Activator Q6PGQ7 79866 13q21.33 human S112-p 27444813 TKDVIVPsPWTDHEG BORA_N molecular association, regulation; phosphorylation cell cycle regulation PLK1(INDUCES); AurA(INDUCES) 27068477; 33771996 3 3 0 +TTK TTK Cancer Testis Antigen (CTA); EC 2.7.12.1; KINASE; Kinase, protein; Protein kinase, Other; Protein kinase, dual-specificity (non-receptor) P33981 7272 6q14.1 human K472-sm 52485004 CFRTPVVkNDFPPAC molecular association, regulation cell cycle regulation BUB1B(DISRUPTS) 26675261 1 0 0 +UVSSA UVSSA Q2YD98 57654 4p16.3 human K414-ub 964554502 DFVEVPEkEGYEPHI intracellular localization 32142649 1 2 0 +AURKA AurA EC 2.7.11.1; KINASE; Kinase, protein; Oncoprotein; Protein kinase, Other; Protein kinase, Ser/Thr (non-receptor) A5GFW1 574063 pig S284-p 2370900 WSVHAPSsRRTTLCG Pkinase cell cycle regulation 18614302 2 0 0 +MAF1 MAF1 Transcription regulation Q9H063 84232 8q24.3 human S68-p 3211920 PPQTSGLsPSRLSKS Maf1 activity, inhibited transcription, induced 20233713; 20516213 2 15 0 +EEF1A1 EEF1A1 Nucleolus; Translation; Translation elongation P68104 1915 6q13 human S396-p 31884110 DGPKFLKsGDAAIVD GTP_EFTU_D3 translation, inhibited 33354788 1 7 0 +RRAGA RRAGA G protein regulator, misc. Q7L523 10670 9p22.1 human K244-ub 15397113 QFKLSCSkLAASFQS molecular association, regulation; phosphorylation autophagy, induced; signaling pathway regulation NPRL3(INDUCES); Raptor(DISRUPTS); DEPDC5(INDUCES); NPRL2(INDUCES) 25936802 1 3 2 interaction with GATOR1 complex, regulates mTORC1 signaling, regulates p70S6K phosphorylation +Mfn1 MFN1 EC 3.6.5.-; Hydrolase; Membrane protein, integral; Membrane protein, multi-pass; Mitochondrial Q811U4 67414 3 A3|3 15.75 cM mouse S86-p 1498941800 AFFGRTSsGKSSVIN Dynamin_N enzymatic activity, inhibited apoptosis, induced 30659190 1 1 0 +Trpm7 ChaK1 Channel, cation; EC 2.7.11.1; KINASE; Kinase, protein; Membrane protein, integral; Membrane protein, multi-pass; Protein kinase, Ser/Thr (non-receptor); Protein kinase, atypical Q923J1 58800 2|2 F1 mouse S1269-p 15499490 NEITRELsISKHLAQ activity, induced 30615643 1 7 1 cAMP dependent Ca2+ influx +ABHD5 ABHD5 EC 2.3.1.51; Lipase; Transferase Q8WTS1 51099 3p21.33 human S237-p 36744500 PDFKRKYsSMFEDDT Abhydrolase_1 protein stabilization; molecular association, regulation; protein conformation ABHD5(DISRUPTS) 35474805 2 1 0 +NF2 Merlin Cytoskeletal; Motility/polarity/chemotaxis; Tumor suppressor P35240 4771 22q12.2 human K449-ub 573763466 EESERRAkEADQLKQ ERM_helical molecular association, regulation; intracellular localization LATS1(DISRUPTS) 30918126 1 2 0 K63 kinked +Csf1r CSFR EC 2.7.10.1; KINASE; Kinase, protein; Membrane protein, integral; Oncoprotein; Protein kinase, TK; Protein kinase, tyrosine (receptor) P09581 12978 18 E1|18 34.41 cM mouse Y706-p 451528 NIHLEKKyVRRDSGF PK_Tyr_Ser-Thr activity, induced; enzymatic activity, induced cytoskeletal reorganization 1652061; 18519746; 7545432; 9000134 12 0 0 +Bad BAD Apoptosis O35147 64639 1q43 rat S113-p 447860 ETRSRHSsYPAGTEE Bcl-2_BAD molecular association, regulation apoptosis, altered 14-3-3 beta(INDUCES); Bcl-xL(DISRUPTS) 15994315; 19344769 129 22 172 +KLF8 KLF8 C2H2-type zinc finger protein; DNA-binding; Transcription factor O95600 11279 Xp11.21 human K93-ac 25344505 PVDLSFHkPKAPLQP sumoylation; molecular association, regulation cell cycle regulation; transcription, inhibited CTBP1(DISRUPTS) 21416054 1 1 0 inhibits sumoylation at KLF8-K67 +Ntrk2 TrkB EC 2.7.10.1; KINASE; Kinase, protein; Membrane protein, integral; Protein kinase, TK; Protein kinase, tyrosine (receptor) P15209 18212 13 B1|13 31.2 cM mouse S478-p 478364 SNDDDSAsPLHHISN molecular association, regulation cytoskeletal reorganization TIAM1(INDUCES) 17341134; 23064382 2 1 0 impaired hippocampal LTP, and impaired memory in water maize and novel object recognition ; dendritic spine density in response to BDNF; dendritic growth +ARHGEF9 ARHGEF9 GAP; GAP, Rac/Rho O43307 23229 Xq11.1 human K515-ub 1873595602 FSRLTPFkK______ protein degradation 29069083 1 0 0 regulates gephyrin clustering and dendritic arborization +EIF2B5 eIF2B-epsilon Translation; Translation initiation Q13144 8893 3q27.1 human S525-p 470490 KINMEEEsESESEQS activity, induced translation, altered 18160716 1 1 0 eIF2B-epsilon [S525A] mutation abolished regulation of protein synthesis by amino acids +Bcl2l11 BIM Apoptosis O54918 12125 2|2 F1 mouse T112-p 449071 SCDKSTQtPSPPCQA protein stabilization; molecular association, regulation apoptosis, altered; apoptosis, induced Bcl-2(INDUCES); Bcl-xL(INDUCES) 18498746; 19841067; 23832115 10 1 0 +NPR1 ANPA EC 4.6.1.2; Guanylyl cyclase; KINASE; Kinase, protein; Lyase; Membrane protein, integral; Nucleotide Metabolism - purine; Protein kinase, RGC; Protein kinase, dual-specificity (receptor); Receptor, misc. P16066 4881 1q21.3 human S529-p 447512 RHLRSAGsRLTLSGR activity, induced; enzymatic activity, induced 28416574; 9528788 3 3 0 +Aurkb AurB EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, Other; Protein kinase, Ser/Thr (non-receptor) O70126 20877 11 B3|11 42.32 cM mouse K102-ub 40212805 NVYLAREkKSRFIVA Pkinase protein degradation cell cycle regulation; carcinogenesis, inhibited; apoptosis, induced 23928698 1 0 0 +MCM2 MCM2 DNA-binding; EC 3.6.4.12 P49736 4171 3q21.3 human S27-p 452310 GNDPLTSsPGRSSRR activity, induced; molecular association, regulation cell cycle regulation; chromatin organization, altered DNA(NOT_REPORTED); DNA(INDUCES) 16446360; 16899510 4 97 63 MMCM2 phosphorylated forms are differentially bound to chromatin. ; regulates ATPase activity in vitro +Mapk1 ERK2 EC 2.7.11.24; KINASE; Kinase, protein; Protein kinase, CMGC; Protein kinase, Ser/Thr (non-receptor) P63085 26413 16 A3|16 10.53 cM mouse T188-p 3949250 FLTEYVAtRWYRAPE Pkinase intracellular localization cytoskeletal reorganization; cell growth, altered 19060905 4 17 17 T 188 phosphorylation induces ERK nuclear localization and cardiac hypertrophy. +PPIA PPIA Cyclophilin; EC 5.2.1.8; Isomerase; RNA-binding P62937 5478 7p13 human K82-ac 461597 GKSIYGEkFEDENFI Pro_isomerase exocytosis, induced; cell adhesion, induced; signaling pathway regulation 24293519 2 8 45 secretion in VSMC, regulates VSMC activation pathway +USF2 USF2 DNA-binding; Transcription factor Q15853 7392 19q13.12 human S155-p 36392500 NPFSNGGsPAAEAVS protein stabilization; molecular association, regulation; protein conformation carcinogenesis, induced; cell growth, induced; cell motility, induced; transcription, induced DNA(INDUCES) 25238393; 31013770 2 3 0 target gene transcription of HO-1, PAI-1, and FAS; Increase in USF2 mRNA expresssion was observed in MDA-MB-231 CDK5 knockout cells +Pou3f2 Oct7 DNA-binding; Motility/polarity/chemotaxis; Transcription factor P31360 18992 4 A3|4 9.73 cM mouse T361-p 22996304 GRKRKKRtSIEVSVK Homeodomain cell cycle regulation; cell motility, induced; transcription, induced 22290434 1 0 0 mutation of this site inhibits PAX3 transcription, but not MITF-M transcription +HTT Huntingtin Cytoskeletal P42858 3064 4p16.3 human S2548-p 40422837 TRFGRKLsIIRGIVE protein degradation 35908190 2 3 0 +STAT4 STAT4 DNA-binding; Transcription factor Q14765 6775 2q32.2-q32.3 human Y693-p 447790 TERGDKGyVPSVFIP molecular association, regulation; intracellular localization cell differentiation, inhibited STAT4(INDUCES); LIFR(INDUCES); STAT3(INDUCES) 30770344 10 5 8 +ARHGAP31 CdGAP GAP; GAP, Rac/Rho Q2M1Z3 57514 3q13.32-q13.33 human S1178-p 484822 ALTGRRNsAPVSVSA molecular association, regulation; intracellular localization transcription, induced; cytoskeletal reorganization; cell motility, inhibited 14-3-3 beta(INDUCES); 14-3-3 sigma(INDUCES) 29545927 1 28 2 14-3-3? inhibits the ability of CdGAP to repress the E-cadherin promoter and to induce cell migration; 14-3-3? sequesters CdGAP into the cytoplasm and inhibits its ability to induce cell rounding +MLH1 MLH1 Cell cycle regulation; DNA repair, damage; Tumor suppressor P40692 4292 3p22.2 human S406-p 12217082 PLSKPLSsQPQAIVT protein stabilization 21864706 1 2 0 +CDKN1A p21Cip1 Cell cycle regulation; Inhibitor P38936 1026 6p21.2 human K154-ub 9897005 MTDFYHSkRRLIFSK protein degradation; ubiquitination cell cycle regulation; carcinogenesis, induced; cell growth, induced 13678583; 17429006; 28446751 5 1 0 +Set SET Apoptosis; DNA replication; DNA-binding; Inhibitor; Nuclear receptor co-regulator; Oncoprotein; Protein phosphatase, regulatory subunit Q9EQU5 56086 2|2 B mouse S7-p 455972 _MAPKRQsAILPQPK protein degradation 30052687 2 39 0 SET protein down regulation through proteosome pathway +RAPH1 RAPH1 Adaptor/scaffold; Motility/polarity/chemotaxis Q70E73 65059 2q33.2 human Y513-p 477344 GKQLYMNyQEALKRT molecular association, regulation cell motility, induced 26996666 2 0 1 Lpd-Scar/WAVE interaction is positively regulated by c-Abl and c-Src, breast cancer cell invasion +BARD1 BARD1 EC 6.3.2.-; EC 6.3.2.19; Ligase; UBIQUITIN LIGASE; Ubiquitin conjugating system; Ubiquitin ligase Q99728 580 2q35 human T394-p 455773 FISLSPGtPPSTLSS cell cycle regulation 15855157 1 10 1 resistance to genotoxic stress (mitomycin C) +Ikbkb IKKB EC 2.7.11.10; KINASE; Kinase, protein; Protein kinase, Other; Protein kinase, Ser/Thr (non-receptor) O88351 16150 8|8 A2 mouse K238-ub 1881186500 WHSKVRQkSEVDIVV molecular association, regulation; phosphorylation NFkB-p105(DISRUPTS) 33523871 1 1 0 ubiquitylation inhibits phosphorylation of p105 +TOP2A TOP2A EC 5.99.1.3; Isomerase P11388 7153 17q21.2 human S1213-p 452237 QMAEVLPsPRGQRVI intracellular localization cell cycle regulation 11699638; 27407105; 30871006 6 65 5 +Spag9 JIP4 iso2 Adaptor/scaffold; Cancer Testis Antigen (CTA) Q58A65-2 70834 11|11 D mouse T351-p 3952367 SGYKGSStPTKGIEN molecular association, regulation FOXK2(INDUCES); PLK1(INDUCES); FOXK1(INDUCES) 26468278 1 6 12 +HDAC1 HDAC1 DEACETYLASE; Deacetylase; EC 3.5.1.98; Hydrolase; Nuclear receptor co-regulator P56517 373961 chicken S406-p 3195746 EDPEKRIsIRNSDKR protein stabilization; molecular association, regulation transcription, induced MBD3(DISRUPTS); HDAC2(INDUCES); MTA1(DISRUPTS) 33596269 2 11 0 no effect on homodimerization +Kcnj1 ROMK Channel, potassium; Membrane protein, integral; Membrane protein, multi-pass P35560 24521 8q21 rat S44-p 449605 RQRARLVsKEGRCNI IRK activity, induced; intracellular localization; protein conformation 12878206; 16118216; 18311184; 29115510 9 0 0 translocates to the plasma membrane +COFILIN Cofilin-1 Cytoskeletal; Motility/polarity/chemotaxis; Nuclear receptor co-regulator P10668 445532 pig S3-p 448444 _____MAsGVAVSDG molecular association, regulation cytoskeletal reorganization ACTB(DISRUPTS) 9078368 97 69 3 S3D mutant disrupts colocalization with actin. S3D mutant fails to rescue cof-1-defective mutant of budding yeast. +Dcp1a DCP1A EC 3.-.-.-; Hydrolase; RNA processing; Transcription, coactivator/corepressor Q91YD3 75901 14 B|14 18.75 cM mouse S335-p 3213294 PSYTLPLsPVLSPTL molecular association, regulation DCP2(INDUCES) 23637887 4 29 10 +OTUB1 OTUB1 DEUBIQUITINASE; EC 3.4.19.12; Protease; Ubiquitin conjugating system; Ubiquitin-specific protease Q96FW1 55611 11q13.1 human Y26-p 14821305 EGVNCLAyDEAIMAQ molecular association, regulation; enzymatic activity, induced carcinogenesis, induced; cell growth, induced; apoptosis, inhibited UBE2D1(INDUCES); Raptor(INDUCES); YpkA(INDUCES); UBE2W(NOT_REPORTED); UBE2N(INDUCES) 20553488; 35927303; 37330581 3 2 0 +Kif21a KIF21A Microtubule-binding; Motor Q9QXL2 16564 15 E3|15 45.86 cM mouse T1161-p 487251 KARRRTTtQMELLYA molecular association, regulation ANKRD15(DISRUPTS) 29158259 1 0 1 +ADD2 ADD2 Cytoskeletal; Motility/polarity/chemotaxis P35612 119 2p13.3 human Y489-p 449419 PNQFVPLyTDPQEVL intracellular localization 16765915 2 4 141 +Foxo1 FOXO1A DNA-binding; Nuclear receptor co-regulator; Oncoprotein; Transcription factor G3V7R4 84482 2q26 rat S206-p 4258803 SSAGWKNsIRHNLSL Forkhead molecular association, regulation; intracellular localization apoptosis, induced 14-3-3 beta(DISRUPTS) 19221179 3 1 0 total 14-3-3 proteins +IFI16 IFI16 Transcription factor Q16666 3428 1q23.1 human K3-ub 1877844700 _____MGkKYKNIVL protein degradation signaling pathway regulation STING(INDUCES) 31665637 1 1 0 IFI16 degradation inhibits viral DNA-induced IFN-I production +GRB10 GRB10 Adaptor/scaffold Q13322 2887 7p12.1 human T155-p 22312200 PGSPPVLtPGSLPPS protein stabilization 21659604 1 0 0 +Gphn gephyrin Adaptor/scaffold; EC 2.10.1.1; EC 2.7.7.75 Q03555 64845 6q24 rat S283-p 2020113 LSTTPSEsPRAQATS protein stabilization; protein conformation neural plasticity; signaling pathway regulation 23408424; 25093719; 31835170 10 23 2 GABA-R signaling-regulates GABA-R diffusion and binding at synapses +SORBS3 vinexin iso2 Adaptor/scaffold; Cell adhesion; Motility/polarity/chemotaxis; Nuclear receptor co-regulator O60504-2 10174 8p21.3 human S188-p 452554 DGPQLPTsPRLTAAA cell growth, induced; cell motility, inhibited; cell adhesion, inhibited 17486060 3 46 40 +Sh3bp4 SH3BP4 Cell cycle regulation; Vesicle Q921I6 98402 1|1 D mouse S245-p 3214461 FRSKRSYsLSELSVL molecular association, regulation 14-3-3 beta(INDUCES) 19122209 2 39 0 +EEF1D EEF1D iso2 Translation; Translation elongation P29692-2 1936 8q24.3 human S499-p 455672 APQTQHVsPMRQVEP transcription, inhibited 33521052 2 108 49 +Ripk1 RIPK1 EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, Ser/Thr (non-receptor); Protein kinase, TKL Q60855 19766 13 A3.3|13 14.01 cM mouse S332-p 4728172 DCVPLPPsRSNSEQP molecular association, regulation; enzymatic activity, induced RIPK3(INDUCES) 28842570 1 3 2 necroptosis +CD300LF IREM-1 Immunoglobulin superfamily; Membrane protein, integral; Receptor, misc. Q8TDQ1 146722 17q25.1 human Y236-p 474548 VDQVEVEyVTMASLP SIT activity, induced; molecular association, regulation; enzymatic activity, induced PIK3R1(INDUCES) 17202342; 32152116 3 0 0 activation of PLC gamma which leads to the activation of PKC; involved in rat basophilic leukemia cell degranulation +Map3k7 TAK1 EC 2.7.11.25; KINASE; Kinase, protein; Protein kinase, Ser/Thr (non-receptor); Protein kinase, TKL Q62073 26409 4|4 A5 mouse S192-p 448289 HMTNNKGsAAWMAPE PK_Tyr_Ser-Thr phosphorylation; enzymatic activity, induced TAB1(INDUCES) 10702308; 27542620 5 1 0 O-GlcNAc modi?cation TAK1 autophosphorylation +IGF1R IGF1R EC 2.7.10.1; KINASE; Kinase, protein; Membrane protein, integral; Protein kinase, TK; Protein kinase, tyrosine (receptor) P08069 3480 15q26.3 human Y1346-p 448389 SFDERQPyAHMNGGR molecular association, regulation; enzymatic activity, induced cell differentiation, altered; cell growth, altered Src(INDUCES) 10786694; 16037379 3 7 28 observed in quadruple mutant Y980/1280/1281/1346F +Scnn1a ENaC-alpha Channel, sodium; Membrane protein, integral; Membrane protein, multi-pass; Transporter, ion channel P37089 25122 4q42 rat S617-p 1877164902 MLLRRFRsRYWSPGR activity, inhibited 35525869 1 0 0 +CHEK2 Chk2 EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, CAMK; Protein kinase, Ser/Thr (non-receptor); Tumor suppressor O96017 11200 22q12.1 human S210-p 12473000 DLTVDDQsVYPKALR enzymatic activity, inhibited cell cycle regulation 20126263 1 1 0 mutation of this site impairs checkpoint recovery +VIM Vimentin Cytoskeletal; Motility/polarity/chemotaxis P08670 7431 10p13 human S26-p 451767 GTASRPSsSRSYVTT Filament_head molecular association, regulation cytoskeletal reorganization Vimentin(DISRUPTS) 11895474 4 15 0 +NPM1 NPM1 Nucleolus; Oncoprotein; RNA-binding; Translation P06748 4869 5q35.1 human S10-p 7105368 DSMDMDMsPLRPQNY molecular association, regulation; intracellular localization; phosphorylation cell cycle regulation CDC25C(INDUCES) 19933706 3 30 0 mutation of S10/S70 to alanine increases CDK1 Y15 phosphorylation; mutation of S10/70 to glutamate decreases Cdc25C S216 phosphorylation +TRPM8 TRPM8 Channel, cation; Membrane protein, integral; Membrane protein, multi-pass Q7Z2W7 79054 2q37.1 human T17-p 12570902 MRNRRNDtLDSTRTL activity, induced 20110357 1 0 0 +RPS6KA1 p90RSK EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, AGC; Protein kinase, Ser/Thr (non-receptor); Translation Q15418 6195 1p36.11 human T359-p 447992 DTEFTSRtPKDSPGI Pkinase_C enzymatic activity, induced 23708659 41 28 2 +MBD4 MBD4 Apoptosis; DNA repair, damage; Deoxyribonuclease; EC 3.2.2.- O95243 8930 3q21.3 human K137-sm 1877787600 KNGETSLkPEDFDFT MBD DNA repair, induced 31476572 1 1 0 +Snca SNCA Adaptor/scaffold O55042 20617 6 B3|6 29.15 cM mouse K10-ac 63341501 VFMKGLSkAKEGVVA Synuclein molecular association, regulation; intracellular localization autophagy, induced; cytoskeletal reorganization SNCA(DISRUPTS) Other(DISRUPTS) 28257421 1 1 0 inhibits binding to lipid membranes +PLCG2 PLCG2 Carbohydrate Metabolism - inositol phosphate; EC 3.1.4.11; Motility/polarity/chemotaxis; Phospholipase P16885 5336 16q23.3 human Y1217-p 447939 LNNQLFLyDTHQNLR enzymatic activity, induced signaling pathway regulation 30344948; 35639855 19 15 346 regulates B cell receptor (BCR) signaling; intramolecular tyrosine-phosphorylation and Rac mediated activation +Pparg PPAR-gamma DNA-binding; Nuclear receptor; Transcription factor P37238 19016 6 E3|6 53.41 cM mouse K107-sm 3617602 QEYQSAIkVEPASPP PPARgamma_N molecular association, regulation; activity, inhibited cell differentiation, inhibited; cell motility, induced; cell growth, induced; apoptosis, inhibited; transcription, altered; transcription, inhibited DNA(DISRUPTS) 16534556; 18832723; 19339015; 20950277; 34249943 15 0 0 SENP3 desumoylated PPAR-gamma and enhanced its activity to promote-the expression of adipogenic marker genes such as C/EBPa, adiponectin and FABP4 +ETV6 Tel DNA-binding; Motility/polarity/chemotaxis; Oncoprotein; Transcription factor P41212 2120 12p13.2 human K11-sm 2798320 TPAQCSIkQERISYT protein degradation; molecular association, regulation transcription, induced DNA(DISRUPTS) 18212042 1 3 0 Tel monomer sumoylation induces degradation +NR3C1 GR DNA-binding; Mitochondrial; Nuclear receptor; Transcription factor P04150 2908 5q31.3 human T594-p 1872513509 LHLDDQMtLLQYSWM Hormone_recep molecular association, regulation 14-3-3 zeta(INDUCES) 33744286 1 0 0 +CAST calpastatin Inhibitor P20810 831 5q15 human S133-p 7320476 DKKKEKKsLTPAVPV Calpain_inhib enzymatic activity, inhibited 36984009 1 14 2 inhibits calpain activity +Pex14 PEX14 Adaptor/scaffold Q642G4 64460 5q36 rat S252-p 27996231 VKSPSPSsPAAVNHH molecular association, regulation; intracellular localization Catalase(DISRUPTS) 32831175 1 9 0 regulates peroxisomal catalase import +H2AFZ H2AZ DNA-binding Q5ZMD6 426361 chicken K7-ac 458910 _AGGKAGkDSGKTKT Histone chromatin organization, altered 19385636 4 14 419 K4, K7, and K11 acetylation destabilizes the nucleosome core particle (NCP) +ACSL4 ACSL4 EC 6.2.1.3; Ligase; Lipid Metabolism - fatty acid; Membrane protein, integral O60488 2182 Xq23 human K498-ub 15383881 PLICCEIkLKDWQEG AMP-binding protein degradation 37428466 1 3 2 inhibition of ACSL4-driven lipid peroxidation and ferroptosis is necessary for CDK1 to promote oxaliplatin resistance in CRC +Rasgrf1 RASGRF1 GEF; GEF, Ras P28818 192213 8q31 rat S781-p 18710205 GKTTLDTsKLCVASS protein degradation 21382555 1 1 0 +MAZ MAZ C2H2-type zinc finger protein; RNA-binding; Transcription factor P56270 4150 16p11.2 human T385-p 449095 KDRLRAHtVRHEEKV transcription, induced DNA(DISRUPTS) 26902421 2 0 0 p53 expression +EIF4G1 eIF4G iso8 RNA-binding; Translation; Translation initiation Q04637-8 1981 3q27.1 human S1239-p 18910225 SPLKAALsEEELEKK molecular association, regulation; phosphorylation Mnk1(INDUCES); eIF3-alpha(DISRUPTS); EIF4B(DISRUPTS); EIF4A1(DISRUPTS) 23263986 1 19 4 induces phosphorylation at S1232; controls formation of translation initiation complex +GYS1 GYS1 Carbohydrate Metabolism - starch and sucrose; EC 2.4.1.11; Transferase P13834 100008660 rabbit S8-p 449898 MPLSRTLsVSSLPGL enzymatic activity, inhibited 10909964; 7929255 16 1 0 simultaneous mutation of both NH2- and COOH-terminal sites was necessary to cause substantial increases in the activity ratio. +CEP131 CEP131 Calcium-binding Q9UPN4 22994 17q25.3 human S21-p 41451326 SPAGVDLsLTGLPPP molecular association, regulation; intracellular localization carcinogenesis, induced; cytoskeletal reorganization; signaling pathway regulation STIL(INDUCES) 31358734 1 3 0 interaction with STIL promotes STIL relocation to the centrioles +CAMK1 CAMK1A EC 2.7.11.17; KINASE; Kinase, protein; Protein kinase, CAMK; Protein kinase, Ser/Thr (non-receptor) Q14012 8536 3p25.3 human T177-p 448527 DPGSVLStACGTPGY Pkinase enzymatic activity, induced 24841198 10 6 7 +MEFV pyrin Actin-binding O15553 4210 16p13.3 human S242-p 455899 SGKMRPRsLEVTIST molecular association, regulation; intracellular localization; activity, inhibited 14-3-3 beta(INDUCES); 14-3-3 theta(INDUCES); 14-3-3 epsilon(INDUCES) 15934090; 27030597; 27270401; 36342970; 36384121 8 7 0 +FYB1 SLAP-130 Adaptor/scaffold O15117 2533 5p13.1 human Y780-p 459246 DIADGCIyDND____ hSH3 cell adhesion, altered 20661443 2 2 17 promotes adhesion to ICAM-1 +GRM7 mGluR7 GPCR, family 3; Membrane protein, integral; Membrane protein, multi-pass; Receptor, GPCR Q14831 2917 3p26.1 human S862-p 2846504 NVQKRKRsFKAVVTA sumoylation 26631532 4 0 0 Ser862 phosphorylation promotes SUMOylation of mGluR7 +AKAP12 AKAP12 Adaptor/scaffold Q02952 9590 6q25.1 human T767-p 3801512 ESFKRLVtPRKKSKS WSK molecular association, regulation; intracellular localization cell cycle regulation; cell growth, induced PLK1(INDUCES) 23063527 2 2 2 +Rb1 Rb Nuclear receptor co-regulator; Oncoprotein; Transcription, coactivator/corepressor; Tumor suppressor P13405 19645 14 38.73 cM|14 D3 mouse S787-p 466966 RSPYKFSsSPLRIPG Rb_C cell cycle regulation; transcription, inhibited 9671466 1 5 70 transcriptional downregulation of the E2F-1, E2F-2, dihydrofolate reductase, thymidine kinase, c-myc, proliferating-cell nuclear antigen, p107, and p21/Cip1 genes +Chek1 Chk1 EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, CAMK; Protein kinase, Ser/Thr (non-receptor); Tumor suppressor O35280 12649 9|9 A4 mouse S301-p 465528 IHSNLDFsPVNNGSS intracellular localization 19837665 5 22 5 +CCNB1 CCNB1 Activator; Cell cycle regulation P14635 891 5q13.2 human S116-p 13256100 PVKEEKLsPEPILVD intracellular localization DNA(INDUCES) 20117088; 22726437 2 1 0 enhances nuclear import +APP APP iso8 Apoptosis; Cell surface; Membrane protein, integral; Receptor, misc.; Transcription factor P05067-8 351 21q21.3 human Y743-p 450343 NGYENPTyKFFEQMQ APP_amyloid protein processing 8132561 4 12 238 +MDM4 MDM4 EC 6.3.2.-; Ligase; UBIQUITIN LIGASE; Ubiquitin conjugating system; Ubiquitin ligase O15151 4194 1q32.1 human S96-p 455615 SFSVKDPsPLYDMLR intracellular localization 15735705 1 0 0 +SIAH1 SIAH1 Apoptosis; Cell development/differentiation; EC 6.3.2.-; EC 6.3.2.19; Ligase; Motility/polarity/chemotaxis; UBIQUITIN LIGASE; Ubiquitin conjugating system; Ubiquitin ligase Q8IUQ4 6477 16q12.1 human Y100-p 457101 SVLFPCKyASSGCEI Sina protein stabilization apoptosis, altered 16230351 1 0 0 +GNAI1 G-alpha i1 G protein; G protein, heterotrimeric; G protein, heterotrimeric alpha G((i/o/t/z)) P63096 2770 7q21.11 human Y320-p 22641096 RKDTKEIyTHFTCAT G-alpha enzymatic activity, induced carcinogenesis, induced; signaling pathway regulation 33139573 1 1 2 +OGG1 OGG1 DNA repair, damage; Deoxyribonuclease; EC 4.2.99.18; Lyase O15527 4968 3p25.3 human K341-ac 40320203 AKRRKGSkGPEG___ DNA repair, induced; apoptosis, inhibited 25660075 1 0 0 +BCL2L11 BIM Apoptosis O43521 10018 2q13 human S87-p 458219 FIFMRRSsLLSRSSS apoptosis, altered; signaling pathway regulation 16282323; 30923040 2 10 1 upregulation of Hedgehog signaling in CLL cells +TTK TTK Cancer Testis Antigen (CTA); EC 2.7.12.1; KINASE; Kinase, protein; Protein kinase, Other; Protein kinase, dual-specificity (non-receptor) P33981 7272 6q14.1 human K71-sm 52485005 DWLSLLLkLEKNSVP molecular association, regulation cell cycle regulation BUB1B(DISRUPTS) 26675261 1 0 0 +STK38 NDR1 EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, AGC; Protein kinase, Ser/Thr (non-receptor) Q15208 11329 6p21.31 human T74-p 460658 SAHARKEtEFLRLKR molecular association, regulation; phosphorylation cytoskeletal reorganization MOB1A(INDUCES); S100B(INDUCES); MOB1B(NOT_REPORTED) 12493777; 19836237 3 0 0 NDR1 Y31A and Y74A mutants showed highly decreased T444 phosphorylation and centrosome amplification. +LALBA LALBA Apoptosis; Secreted; Secreted, signal peptide; Transferase P00711 281894 cow S89-p 1875112302 DDQNPHSsNICNISC Lys molecular association, regulation; protein conformation IGE(DISRUPTS); IgG(DISRUPTS) 34655828 0 1 0 +KRT18 K18 Cytoskeletal; Nucleolus P05783 3875 12q13.13 human S34-p 447733 RPVSSAAsVYAGAGG molecular association, regulation; intracellular localization; phosphorylation cell motility, induced; apoptosis, induced; cytoskeletal reorganization 14-3-3 beta(INDUCES); 14-3-3 zeta(INDUCES) 10623656; 11917136; 14694114; 15368451; 19246484; 27059955 14 27 13 O-GlcNAcylation at S31 determines the occurrence of phosphorylation at S34, maintaining the normal filament organization of keratin 18 +SIRT1 SIRT1 Apoptosis; DEACETYLASE; Deacetylase; EC 3.5.1.-; Nuclear receptor co-regulator Q96EB6 23411 10q21.3 human K519-ub 1877148900 EKPPRTQkELAYLSE protein degradation carcinogenesis, inhibited; cell growth, inhibited; cell motility, inhibited 32361710 1 1 0 +PINX1 PINX1 Inhibitor; Nucleolus; Tumor suppressor Q96BK5 54984 8p23.1 human S226-p 14823405 ATGKDVEsYLQPKAK protein degradation; ubiquitination 20573420 1 1 0 +Stmn1 STMN1 Cytoskeletal P13668 29332 5q36 rat S38-p 448556 SVPEFPLsPPKKKDL Stathmin apoptosis, inhibited; cytoskeletal reorganization 24302736; 25285524; 31933182 49 114 166 increase microtubule depolymerization +Mlkl MLKL KINASE; Kinase, protein; Protein kinase, Ser/Thr (non-receptor); Protein kinase, TKL Q9D2Y4 74568 8|8 E1 mouse T349-p 8148779 TQNSISRtAKSTKAE PK_Tyr_Ser-Thr protein conformation 26024392 2 1 1 +MAP2K1 MEK1 EC 2.7.12.2; KINASE; Kinase, protein; Protein kinase, STE; Protein kinase, dual-specificity (non-receptor) Q02750 5604 15q22.31 human K175-ac 35480411 KVSIAVIkGLTYLRE Pkinase enzymatic activity, induced cell growth, induced; transcription, induced; signaling pathway regulation 24681949; 34965411 2 0 0 activation of dynamin-related protein 1 (DRP1), metabolic reprogramming, glycolytic switching +Rps6kb1 p70S6K EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, AGC; Protein kinase, Ser/Thr (non-receptor); Translation Q8BSK8 72508 11|11 C mouse T444-p 448358 RFIGSPRtPVSPVKF molecular association, regulation; enzymatic activity, induced cell differentiation, altered DEDD(INDUCES) 10846175; 19106089 106 37 109 +FXR1 FXR1 RNA-binding; Translation P51114 8087 3q26.33 human S420-p 467926 SERKDELsDWSLAGE FXMRP1_C_core intracellular localization 20417602 1 28 26 +AKT1 Akt1 EC 2.7.11.1; KINASE; Kinase, protein; Oncoprotein; Protein kinase, AGC; Protein kinase, Ser/Thr (non-receptor) P31749 207 14q32.33 human K301-sm 31089527 GLCKEGIkDGATMKT Pkinase cell cycle regulation; RNA splicing, induced 24013425 1 0 0 +DPYSL2 CRMP-2 Microtubule-binding; Motility/polarity/chemotaxis Q16555 1808 8p21.2 human Y499-p 463170 RGVPRGLyDGPVCEV molecular association, regulation cytoskeletal reorganization 29396402 1 9 327 signi?cantly impair the microtubule bundling activity of CRMP2, impaired binding to microtubules +KHDC3L KHDC3L Cell cycle regulation Q587J8 154288 6q13 human T156-p 25285513 VEVREAGtQRSVEVQ activity, induced; molecular association, regulation DNA repair, induced; cell growth, induced PARP1(INDUCES) 31609975 1 0 1 +PSEN1 PSEN1 Cell surface; EC 3.4.23.-; Membrane protein, integral; Membrane protein, multi-pass; Mitochondrial; Protease P49768 5663 14q24.2 human S353-p 448562 SHLGPHRsTPESRAA Presenilin molecular association, regulation; intracellular localization; protein conformation cell growth, altered CTNNB1(DISRUPTS); CDH2(DISRUPTS); CTNNB1(INDUCES) 11104755; 17360711; 17389597 3 0 9 GSK3beta activation downregulates PI3K/Akt signaling probably by reducing the interaction of PSEN1 with N-cadherin (CDH2)/ beta catenin (CTNNB1); reduced interaction was observed in the constitutively active GSK3beta (S9A) mutant; stabilizes beta catenin by reducing its ubiquitination and turn-over +Slc12a1 NKCC2 Membrane protein, integral; Membrane protein, multi-pass; Transporter; Transporter, SLC family P55014 20495 2 F1|2 61.23 cM mouse T101-p 458228 LQTFGHNtMDAVPKI AA_permease_N activity, induced 12732642; 24808538 14 2 0 +TP53 p53 Activator; DNA-binding; Motility/polarity/chemotaxis; Nuclear receptor co-regulator; Transcription factor; Tumor suppressor P04637 7157 17p13.1 human K372-ac 458982 HSSHLKSkKGQSTSR protein degradation; molecular association, regulation; protein stabilization; ubiquitination; intracellular localization cell growth, induced; cell growth, inhibited; apoptosis, induced; transcription, induced; transcription, altered polybromo 1(INDUCES); BCL2L2(INDUCES); p21Cip1(DISRUPTS) DNA(INDUCES) 11094089; 11099047; 11250899; 11971195; 12421820; 14982997; 16291740; 18485870; 19339993; 19377469; 21297583; 31680191; 31863007; 36257192; 9288740 25 3 0 promoting the C-terminal acetylation of p53 and may facilitate p53-dependent gene expression ; PBRM1 is a reader for p53 acetylation on lysine 382 (K382Ac); 20, 164, 305, 320, 370/372/373, 381/382/386 K-R mutants diminsished transactivation, and selective regulation of target genes expression through distinct mechanisms; ZNF420 (Apak) represses p53 activity by attenuating its acetylation +Lhcgr LHR GPCR, family 1; Membrane protein, integral; Membrane protein, multi-pass; Receptor, GPCR P16235 25477 6q12 rat S675-p 451064 KNGFPGAsKPSQATL receptor internalization, altered 9660797 1 0 0 S675 is essential for agonist-induced internalization but not for agonist-induced uncoupling. +EPAS1 HIF2A DNA-binding; Transcription factor Q99814 2034 2p21 human T528-p 59087902 FNELDLEtLAPYIPM HIF-1 intracellular localization transcription, induced 27686097 2 1 0 EPO secretion, inhibits CRM1-dependent nuclear export of HIF2A +KCNK2 TREK-1 iso2 Channel, potassium; Membrane protein, integral; Membrane protein, multi-pass O95069-2 3776 1q41 human S333-p 456161 KETRRRLsVEIYDKF activity, inhibited neural plasticity 33006141 8 5 0 +STAT5B STAT5B DNA-binding; Oncoprotein; Transcription factor P51692 6777 17q21.2 human Y743-p 448736 PQAHYNMyPQNPDSV activity, inhibited transcription, altered; transcription, inhibited 16772534; 17822672 4 0 0 transcriptional activation of STAT5B Y740/743 mutant requires phosphorylation of S731 and Y699 +HADHA HADHA ACETYLTRANSFERASE; Acetyltransferase; Amino Acid Metabolism - lysine degradation; Amino Acid Metabolism - tryptophan; Amino Acid Metabolism - valine, leucine and isoleucine degradation; Carbohydrate Metabolism - butanoate; Carbohydrate Metabolism - propanoate; EC 1.1.1.211; EC 4.2.1.17; Lipid Metabolism - fatty acid; Lipid Metabolism - fatty acid elongation in mitochondria; Lipid Metabolism - unsaturated fatty acid biosynthesis; Lyase; Mitochondrial; Other Amino Acids Metabolism - beta-alanine; Oxidoreductase; Secondary Metabolites Metabolism - limonene and pinene degradation P40939 3030 2p23.3 human K406-ac 461764 RGQQQVFkGLNDKVK 3HCDH_N protein stabilization 27457618 2 9 23 3 sites can be acetylated or ubiquitylated, acetylation blocks ubiquitylation +TP53 p53 Activator; DNA-binding; Motility/polarity/chemotaxis; Nuclear receptor co-regulator; Transcription factor; Tumor suppressor P04637 7157 17p13.1 human K320-ac 458976 SSSPQPKkKPLDGEY P53_tetramer activity, induced; protein stabilization; molecular association, regulation; intracellular localization carcinogenesis, inhibited; cell growth, inhibited; apoptosis, induced; transcription, induced; neural plasticity; cell growth, induced; apoptosis, inhibited; transcription, inhibited p53(INDUCES); SIN3A(INDUCES); PCAF(INDUCES) DNA(INDUCES) 10891493; 11250899; 12501250; 12716906; 15141169; 16540664; 16717128; 16946709; 17403783; 17977830; 18419600; 18574470; 19265193; 19339993; 20094059; 21297583; 23329847; 24330748; 27208501; 31196136; 31296660; 31634504; 31680191; 35534985; 9744860; 9891054 56 2 0 +RXRA RXRA DNA-binding; Motility/polarity/chemotaxis; Nuclear receptor P19793 6256 9q34.2 human S49-p 333674901 GSPGQLHsPISTLSS Nuc_recep-AF1 ubiquitination carcinogenesis, induced; transcription, induced; signaling pathway regulation 29137318; 30518934 2 0 0 PI3K/AKT signaling ; PIK3CA transcription; negatively regulated beta-catenin expression by ubiquitination of ?-catenin in CRC +Flnc FLNC Cytoskeletal; Motility/polarity/chemotaxis Q8VHX6 68794 6 A3.3|6 12.36 cM mouse S2625-p 15403523 SSSSRGAsYSSIPKF protein stabilization 28028127 1 15 0 +MEF2D MEF2D DNA-binding; Transcription factor Q14814 4209 1q22 human K267-m2 31094531 QLGAPSRkPDLRVIT molecular association, regulation cell differentiation, inhibited; transcription, inhibited DNA(DISRUPTS) 24078251 1 1 0 +POU5F1 Oct4 DNA-binding; Transcription factor Q01860 5460 6p21.33 human S93-p 25236708 PQGGLETsQPEGEAG transcription, induced 33565603 2 1 0 +MAP2K6 MKK6 EC 2.7.12.2; KINASE; Kinase, protein; Protein kinase, STE; Protein kinase, dual-specificity (non-receptor) P52564 5608 17q24.3 human T211-ac 4325702 LVDSVAKtIDAGCKP Pkinase enzymatic activity, inhibited; phosphorylation 16728640 2 0 0 yopJ inhibits MKK6 phosphorylation and its enzymatic activation in vitro +Tp53 p53 Activator; DNA-binding; Motility/polarity/chemotaxis; Nuclear receptor co-regulator; Transcription factor; Tumor suppressor P02340 22059 11 B3|11 42.83 cM mouse S58-p 2624500 EEFFEGPsEALRVSG apoptosis, inhibited; transcription, induced 16729035; 19118006 2 0 0 crucial for induction of transcription of p21, SESN2, Bbc3, and Bax; HIPK2 induced apoptosis is p53 dependent. +RRAGC RRAGC Q9HB90 64121 1p34.3 human S21-p 14579528 GSYGAADsFPKDFGY molecular association, regulation; phosphorylation cell growth, induced; autophagy, inhibited Raptor(INDUCES); mTOR(DISRUPTS) 30552228 1 7 0 induces Ulk1 and p70S6K phosphorylation, regulates mTORC1 raptor complex stability +RPS6KA3 RSK2 EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, AGC; Protein kinase, Ser/Thr (non-receptor) P51812 6197 Xp22.12 human S369-p 448064 TAKTPKDsPGIPPSA Pkinase_C protein conformation; enzymatic activity, induced transcription, induced 15657420; 17446865 10 51 20 +ABL1 Abl EC 2.7.10.2; KINASE; Kinase, protein; Oncoprotein; Protein kinase, TK; Protein kinase, tyrosine (non-receptor) P00519 25 9q34.12 human Y393-p 450298 RLMTGDTyTAHAGAK PK_Tyr_Ser-Thr enzymatic activity, induced cell cycle regulation; carcinogenesis, inhibited; apoptosis, induced; cell growth, inhibited; cell growth, altered 35569509; 36079767; 8441409 24 49 1642 +SPAG5 SPAG5 Cell cycle regulation Q96R06 10615 17q11.2 human S115-p 34824800 ISSTPKTsEEAVDPL activity, induced; molecular association, regulation cell cycle regulation; cell growth, altered Securin(INDUCES); CLASP1(INDUCES); SKAP55(INDUCES) 25009111 1 0 0 progression of mitosis; Separase activation +ERBB4 HER4 EC 2.7.10.1; KINASE; Kinase, protein; Membrane protein, integral; Protein kinase, TK; Protein kinase, tyrosine (receptor) Q15303 2066 2q34 human Y1022-p 36100601 DMMDAEEyLVPQAFN molecular association, regulation cell motility, induced CSK(INDUCES); VAV3(INDUCES); CRK(INDUCES) 16729043; 32561640 2 0 0 +Tp53 p53 Activator; DNA-binding; Motility/polarity/chemotaxis; Nuclear receptor co-regulator; Transcription factor; Tumor suppressor P02340 22059 11 B3|11 42.83 cM mouse K136-ac 1877365921 KLFCQLAkTCPVQLW P53 carcinogenesis, inhibited 33303641 1 0 0 +Prdx1 PRDX1 EC 1.11.1.15; Nuclear receptor co-regulator; Oxidoreductase P35700 18477 4 D1|4 53.28 cM mouse Y194-p 448924 DVNKSKEyFSKQK__ 1-cysPrx_C molecular association, regulation; enzymatic activity, inhibited carcinogenesis, induced LOX(DISRUPTS) 34389806 2 8 138 +IFITM3 IFITM3 Cell surface; Membrane protein, integral Q01628 10410 11p15.5 human Y20-p 463584 NSGQPPNyEMLKEEH activity, induced; ubiquitination; intracellular localization endocytosis, inhibited 23055554; 24627473; 26354436; 29263263 5 10 18 ubiquitination, decreased +PGR PR DNA-binding; Nuclear receptor; Transcription factor P06401 5241 11q22.1 human S345-p 450157 AFAPPRSsPCASSTP Prog_receptor molecular association, regulation transcription, induced SP1(INDUCES) 18202149; 8662865 6 1 0 +LDHA LDH-A Amino Acid Metabolism - cysteine and methionine; Apoptosis; Carbohydrate Metabolism - glycolysis and gluconeogenesis; Carbohydrate Metabolism - propanoate; Carbohydrate Metabolism - pyruvate; EC 1.1.1.27; Oxidoreductase P00338 3939 11p15.1 human S161-p 31882218 PKNRVIGsGCNLDSA protein stabilization; molecular association, regulation 14-3-3 epsilon(INDUCES) 36239424 1 4 0 inhibits nuclear ubiquitination/ polyubiquitination +DNAJC6 DNAJC6 Chaperone; EC 3.1.3.48; Motility/polarity/chemotaxis; PHOSPHATASE; Protein phosphatase, tyrosine (non-receptor) O75061 9829 1p31.3 human S570-p 2518108 SATSTSAsPTLRVGE molecular association, regulation CLTC(DISRUPTS) 29735704 2 15 6 +Tpt1 TPT1 Calcium-binding; Microtubule-binding P63029 116646 15q11 rat S9-p 40584901 IIYRDLIsHDELFSD TCTP intracellular localization 25854427 1 1 0 +BECN1 beclin 1 Adaptor/scaffold; Autophagy; Membrane protein, peripheral Q14457 8678 17q21.31 human K437-ub 41159602 KFMLTNLkWGLAWVS APG6 molecular association, regulation autophagy, induced PIK3C3(INDUCES) 23974797 1 0 0 +TIRAP TIRAP Adaptor/scaffold P58753 114609 11q24.2 human Y106-p 463809 AAQDLVSyLEGSTAS TIR_2 activity, induced; molecular association, regulation; phosphorylation transcription, induced; signaling pathway regulation TLR4(DISRUPTS); MYD88(DISRUPTS); Btk(INDUCES); P38A(INDUCES) 16439361; 18070880; 24840642; 35379857 4 0 1 TLR2/TLR4 signaling +SATB1 SATB1 DNA-binding; Transcription factor Q01826 6304 3p24.3 human K136-ac 464646 KGLIQVGkWNPVPLS ULD molecular association, regulation transcription, induced DNA(DISRUPTS) 16630892 1 0 0 Upregulates gene expression +CAV1 caveolin-1 Adaptor/scaffold; Motility/polarity/chemotaxis; Nuclear receptor co-regulator Q03135 857 7q31.2 human K26-ub 486921 REQGNIYkPNNKAMA molecular association, regulation; intracellular localization UBXN6(INDUCES); VCP(INDUCES) 23335559 1 8 6 CAV1 ubiquitylation and binding to the VCP-UBXD1 complex and sorting into lysosomes +FGF23 FGF23 Cytokine; Secreted; Secreted, signal peptide Q9GZV9 8074 12p13.32 human S180-p 33365504 IPRRHTRsAEDDSER protein degradation; O-GalNAc glycosylation 24706917 2 2 0 S180 phosphorylation inhibits T178 O-GalNAc glycosylation, promotes FGF23 cleavage +Lipe HSL EC 3.1.1.79; Lipase P54310 16890 7 A3|7 13.78 cM mouse S557-p 448803 PTESMRRsVSEAALA enzymatic activity, induced; phosphorylation signaling pathway regulation 19942859; 20332342; 30126894 41 11 2 Phosphorylation of HSL leads to lipolysis and browning of adipose tissue; inhibits phosphorylation at S559; Rictor/mTORC2 signaling in energy metabolism in fat cells +STK38 NDR1 EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, AGC; Protein kinase, Ser/Thr (non-receptor) Q15208 11329 6p21.31 human Y31-p 2526142 KVTLENFySNLIAQH molecular association, regulation; phosphorylation cytoskeletal reorganization MOB1A(INDUCES); MOB1B(NOT_REPORTED) 19836237 1 0 8 NDR1 Y31A and Y74A mutants showed highly decreased T444 phosphorylation and centrosome amplification. +FCRL4 FCRL4 Membrane protein, integral Q96PJ5 83417 1q23.1 human Y451-p 22730002 QVELQSLyVDVHPKK molecular association, regulation signaling pathway regulation Ig-alpha(INDUCES) 21908428; 25972488 2 0 0 all 3 sites (Y451, Y463, Y493) inhibits BCR signaling and enhances TLR9 signaling +NCF1 p47phox EC 1.-.-.-; Oxidoreductase P14598 653361 7q11.23 human S348-p 451728 PGPQSPGsPLEEERQ intracellular localization; enzymatic activity, induced carcinogenesis, induced; cell growth, induced 24632950 9 7 0 induces NOX1 activation and ROS generation +SLC6A2 SLC6A2 Membrane protein, integral; Membrane protein, multi-pass; Transporter; Transporter, SLC family P23975 6530 16q12.2 human T30-p 4957152 QPLRARKtAELLVVK intracellular localization endocytosis, inhibited 21498515; 28017803 2 0 0 transport, surface trafficking; reduced surface expression in T30A mutatnt +SIRPA SHPS1 Cell adhesion; Cell surface; Membrane protein, integral; Motility/polarity/chemotaxis; Receptor, misc. P78324 140885 20p13 human Y453-p 1861200 EPNNHTEyASIQTSP molecular association, regulation; phosphorylation cell motility, induced; cell growth, induced; signaling pathway regulation SHP-2(INDUCES); SHP-1(INDUCES) 10842184; 18233962; 21799000 4 2 5 regulation TLR3/4-dependent cytokine production pathway; induces phosphorylation of MAPK, regulates SHPS-1 signaling; Mutation of these 4 tyrosines does not affect JAK2 binding. However, overexpression of the WT SHPS1 but not the 4 tyrosine to phenylalanine mutation reduces tyrosine phosphorylation of Jak2, STAT5B, and STAT3 and activation of Erk1/2 in response to growth hormone. Does not affect STAT3 tyrosine phosphorylation in response to LIF agonist. +Ric8a RIC8A GEF; GEF, misc. NP_001093990 293614 1q41 rat S435-p 468627 GRPEGQYsEDEDTDT Ric8 activity, induced; protein stabilization; molecular association, regulation; protein conformation G-alpha i1(INDUCES) 29844055; 31155309; 31300652 2 58 64 G-alpha subunit guanine nucleotide exchange; G-alpha subunit folding; Phosphorylation at S435 and T440 augment stabilization of intramolecular electrostatic interactions in RIC8A; induces GEF activity +Mpl MPL Membrane protein, integral; Receptor, cytokine Q08351 17480 4 D2.1|4 54.61 cM mouse T569-p 3091408 LPKSSEStPLPLCPS activity, induced; phosphorylation cell growth, altered 10918061 1 0 0 tyrosine phosphorylation of JAK2 +APBB1 Fe65 Adaptor/scaffold; Apoptosis; Transcription regulation O00213 322 11p15.4 human T579-p 288031700 SSSREQWtPSHVSVA PID molecular association, regulation; intracellular localization; protein conformation APP(INDUCES) 28963516 1 0 0 promotes the amyloidogenic processing of APP; suppresses FE65-PTB2 dimerization; gamma-secretase cleavage of APP; cytoplasmic retention by enhancing FE65/APP interaction +AHR AHR DNA-binding; Transcription factor P35869 196 7p21.1 human T697-p 1874101926 EMDSMPYtQNFISCN protein degradation; ubiquitination autophagy, induced; transcription, induced 34198826 1 0 0 +IRF7 IRF7 DNA-binding; Transcription factor Q92985 3665 11p15.5 human K444-ub 4666607 DLSAGRPkEKSLVLV IRF-3 transcription, induced 18710948 1 0 0 +STX17 STX17 Membrane protein, integral; Membrane protein, multi-pass; Vesicle P56962 55014 9q31.1 human S289-p 4774791 MMEKLTSsCPDLPSQ molecular association, regulation; intracellular localization autophagy, induced FLNA(INDUCES) 37389864 1 16 5 +FERMT2 kindlin-2 Cytoskeletal; Motility/polarity/chemotaxis Q96AC1 10979 14q22.1 human K153-ub 1875153101 DPTKKKKkKLDDQSE protein degradation cell adhesion, inhibited 28408404 1 0 0 +APH1A APH1A Apoptosis; Endoplasmic reticulum; Membrane protein, integral; Membrane protein, multi-pass Q96BI3 51107 1q21.2 human S103-p 1877641902 KADEGLAsLSEDGRS Aph-1 molecular association, regulation; enzymatic activity, altered ARRB2(INDUCES) 35858570 1 1 0 +Yap1 YAP1 Oncoprotein; Transcription, coactivator/corepressor P46938 22601 9|9 A1 mouse S46-p 484116 VVHVRGDsETDLEAL intracellular localization carcinogenesis, induced; cell differentiation, induced; transcription, induced 33574090 13 47 1 +Mark1 MARK1 EC 2.7.11.1; EC 2.7.11.26; KINASE; Kinase, protein; Protein kinase, CAMK; Protein kinase, Ser/Thr (non-receptor) O08678 117016 13q26 rat S219-p 456805 KLDTFCGsPPYAAPE Pkinase enzymatic activity, induced 9108484 1 10 11 +Smo SMO Cell development/differentiation; GPCR, Fz/Smo family; Membrane protein, integral; Membrane protein, multi-pass; Oncoprotein; Receptor, GPCR P56726 319757 6 A3.3|6 12.36 cM mouse T597-p 1872776116 ELSFSMHtVSHDGPV molecular association, regulation transcription, induced PKACA(INDUCES) 33886552 1 1 0 +PARVA PARVA Adaptor/scaffold; Motility/polarity/chemotaxis Q9NVD7 55742 11p15.3 human S4-p 4270096 ____MATsPQKSPSV molecular association, regulation; enzymatic activity, induced cell motility, induced; cell adhesion, induced ARHGEF7(INDUCES); PAK1(INDUCES) 15353548; 22955285 2 7 0 Matrix degradation, Src and MMP2 activity +Smad7 SMAD7 DNA-binding; Transcription factor O35253 17131 18|18 E3 mouse S249-p 12559510 APGGLSDsQLLLEPG transcription, induced; transcription, inhibited 11278814 1 0 0 Smad7 activates or inhibits transcription depending on promoter context. S249 phosphorylation is important for both activation and inhibition. +MAPK14 P38A EC 2.7.11.24; KINASE; Kinase, protein; Protein kinase, CMGC; Protein kinase, Ser/Thr (non-receptor) Q16539 1432 6p21.31 human R149-me 1877038903 HSADIIHrDLKPSNL Pkinase molecular association, regulation; phosphorylation; enzymatic activity, induced cell differentiation, induced MAPKAPK2(INDUCES); MKK3(INDUCES) 32429593 1 1 0 augments phosphorylation by MKK3 and enhances the activation of p38-alpha +IRF3 IRF3 DNA-binding; Transcription factor Q14653 3661 19q13.33 human K98-ub 1877340002 RLAEDRSkDPHDPHK IRF transcription, induced DNA(INDUCES) 32075857 1 0 0 +NFKB1 NFkB-p105 DNA-binding; Transcription factor P19838 4790 4q24 human S923-p 447769 DELRDSDsVCDSGVE protein degradation 10469655 2 2 2 +ERBB2 HER2 EC 2.7.10.1; KINASE; Kinase, protein; Membrane protein, integral; Oncoprotein; Protein kinase, TK; Protein kinase, tyrosine (receptor) P04626 2064 17q12 human Y1005-p 458003 SPLDSTFyRSLLEDD molecular association, regulation SHC1(INDUCES) 16729043 1 5 75 +PAPOLA PAP-alpha EC 2.7.7.19; RNA processing; RNA splicing; Transferase P51003 10914 14q32.2 human K641-ac 483062 TSGNAATkIPTPIVG molecular association, regulation; intracellular localization CPSF6(DISRUPTS); CFIM25(DISRUPTS) 17172643 1 1 0 cytoplasmic localization +Anxa2 ANXA2 Calcium-binding; Lipid-binding; Motility/polarity/chemotaxis P07356 12306 9 C|9 38.58 cM mouse Y24-p 449483 HSTPPSAyGSVKPYT molecular association, regulation; intracellular localization; activity, inhibited cell adhesion, induced; cytoskeletal reorganization; endocytosis, inhibited NKCC2(INDUCES); OMP(INDUCES) 21737841; 24526686; 24742684; 25775977; 32442363; 34684255 29 64 2613 +Gria1 GluR1 Channel, calcium; Channel, ligand-gated; Membrane protein, integral; Membrane protein, multi-pass P23818 14799 11 B1.3|11 34.51 cM mouse S849-p 448565 FCLIPQQsINEAIRT activity, induced; molecular association, regulation; receptor desensitization, altered; intracellular localization; receptor internalization, altered; receptor recycling, altered; phosphorylation neural plasticity; signaling pathway regulation NMDAR1(INDUCES) 12628184; 17360685; 17689977; 17880895; 17923095; 18455244; 21483826; 21516102; 24038144; 33526688 94 4 3 +Ppargc1b PGC-1 beta Nuclear receptor co-regulator; Transcription, coactivator/corepressor Q8VHJ7 170826 18|18 E1 mouse K726-ac 7761204 APLPTETkAPRREAN intracellular localization transcription, inhibited 19491097 1 1 0 +DNM2 DYN2 EC 3.6.5.5; Hydrolase; Microtubule-binding; Motility/polarity/chemotaxis; Vesicle P50570 1785 19p13.2 human S764-p 3191449 LQSASSHsPTPQRRP molecular association, regulation; intracellular localization cell cycle regulation 20889493; 21195118 5 9 0 important for cytokinesis; reduces microtubule-binding activity of DYN2 +SP1 SP1 C2H2-type zinc finger protein; DNA-binding; Transcription factor P08047 6667 12q13.13 human T278-p 1988302 SVSAATLtPSSQAVT molecular association, regulation; protein stabilization cell differentiation, inhibited; cell cycle regulation; cell growth, induced; transcription, induced; transcription, inhibited DNA(DISRUPTS) 18199680; 19245816; 32205409 4 0 0 regulates cell proliferation; protects from ubiquitin-dependent degradation during mitosis; during mitosis; reduces binding to FBXL2 promoter +SKAP1 SKAP55 Adaptor/scaffold; Motility/polarity/chemotaxis Q86WV1 8631 17q21.32 human Y232-p 451308 EEEKEETyDDIDGFD molecular association, regulation; intracellular localization; phosphorylation transcription, induced CD45(INDUCES) 11909961 1 0 1 +WWC1 KIBRA Adaptor/scaffold Q8IX03 23286 5q34 human S947-p 453630 CRLNRSDsDSSTLSK cell motility, induced; cell growth, induced 24269383 1 18 46 +VGLL4 VGLL4 iso4 Transcription, coactivator/corepressor Q14135-4 9686 3p25.3-p25.2 human S280-p 458220 SRRGQPAsPSAHMVS cell cycle regulation; cell growth, induced 28739871 1 14 53 Mitotic phosphorylation +MAP3K3 MEKK3 EC 2.7.11.25; KINASE; Kinase, protein; Protein kinase, STE; Protein kinase, Ser/Thr (non-receptor) Q99759 4215 17q23.3 human T516-p 12607405 GASKRLQtICMSGTG Pkinase enzymatic activity, induced 20068038 2 0 0 essential for MEKK3-mediated IKK-beta/NFkB activation +Aatk Lmr1 iso2 EC 2.7.11.1; KINASE; Kinase, protein; Membrane protein, integral; Protein kinase, Ser/Thr (non-receptor); Protein kinase, TK; Protein kinase, tyrosine (receptor) Q80YE4-2 11302 11|11 E2 mouse S34-p 14364500 ADFSEQGsPAAAAQT molecular association, regulation; intracellular localization; phosphorylation cell growth, inhibited; cytoskeletal reorganization RAB11A(DISRUPTS) 20422042; 20553326; 22573681; 24672056 4 0 0 Regulates RAB11A activity; influences transferrin uptake and recycling; inhibits tyrosine phosphorylation of Lmr1; decreased dendritic arborization +RASAL2 RASAL2 iso2 GAP; GAP, Ras Q9UJF2-2 9462 1q25.2 human S237-p 468582 PKLKESRsHESLLSP carcinogenesis, induced 31759919 1 14 0 +IL16 IL16 Cytokine; DNA-binding; Motility/polarity/chemotaxis Q14005 3603 15q25.1 human S743-p 11280302 MPLQPNAsLNEEEGT intracellular localization cell cycle regulation 12450396 1 1 0 regulate nuclear localization +Cdk1 CDK1 Cell cycle regulation; EC 2.7.11.22; EC 2.7.11.23; KINASE; Kinase, protein; Motility/polarity/chemotaxis; Protein kinase, CMGC; Protein kinase, Ser/Thr (non-receptor) P11440 12534 10 B5.3|10 36.07 cM mouse T161-p 447609 GIPIRVYtHEVVTLW Pkinase phosphorylation; enzymatic activity, induced cell cycle regulation; carcinogenesis, induced; carcinogenesis, altered; apoptosis, inhibited; cell growth, altered 33761914; 35508654; 35694267 44 43 83 induces Rb phosphorylation +Cdkn1c p57Kip2 Cell cycle regulation; Inhibitor; Nuclear receptor co-regulator; Tumor suppressor P49919 12577 7 F5|7 88.22 cM mouse S19-p 22354700 TAMERLAsSDTFPVI protein degradation; ubiquitination cell cycle regulation; apoptosis, inhibited; transcription, inhibited 21791608 1 1 0 +CTNNB1 CTNNB1 Actin-binding; Cell adhesion; Motility/polarity/chemotaxis; Nuclear receptor co-regulator; Oncoprotein; Transcription factor P35222 1499 3p22.1 human K49-ac 458938 TAPSLSGkGNPEEED acetylation; molecular association, regulation; protein stabilization; ubiquitination; intracellular localization; phosphorylation carcinogenesis, induced; carcinogenesis, inhibited; cell motility, induced; transcription, induced; cell differentiation, induced; cell growth, induced; apoptosis, inhibited; transcription, inhibited LEF-1(INDUCES); HDAC7(INDUCES); Bcl-3(INDUCES) 18356165; 18987336; 21952047; 23727580; 25546293; 26477307; 28329675; 30691485; 31930681; 32355204; 32581357; 35277183; 35494070 17 0 0 higher intracellular pH leads to activation of mesodermal transcriptional WNT targets; HDAC7 expresssion promotes ?-catenin nuclear import, Wnt pathway target gene protein expression were downregulated; CK1d/CK1?/beta-catenin/Tip60 complexes are in colon cancer cells, treatment with CK1 or Tip60 inhibitors downregulate the level of beta-catenin acetylation and inhibit viability and proliferation of colon cancer cells, transcription of Wnt target genes ; high level of Ac-K49 beta-catenin to promote Wnt/?-catenin activity; promotes nuclear translocation, inhibits phosphorylation and ubiquitination +RELA NFkB-p65 DNA-binding; Nuclear receptor co-regulator; Transcription factor Q04206 5970 11q13.1 human T435-p 451422 PTQAGEGtLSEALLQ transcription, inhibited 20001970 2 0 0 +GATA6 GATA6 Motility/polarity/chemotaxis; Transcription factor Q92908 2627 18q11.2 human S37-p 15419868 REPSTPPsPISSSSS protein degradation transcription, induced 27273097 1 4 5 alleviates GATA6 repression of transcription +DGCR8 DGCR8 Nucleolus; RNA processing; RNA-binding Q8WYQ5 54487 22q11.21 human S383-p 31864184 VSPVKPLsRSAELEF protein stabilization 24239349 0 3 0 +NFATC1 NFAT2 DNA-binding; Transcription factor O95644 4772 18q23 human S187-p 465578 RSCNSEAsSYESNYS intracellular localization 10652349 1 0 1 cooperates with S172 to induce nuclear localization of NFAT2 +Ptk2 FAK EC 2.7.10.2; KINASE; Kinase, protein; Protein kinase, TK; Protein kinase, tyrosine (non-receptor) O35346 25614 7q34 rat S913-p 447964 RLQPQEIsPPPTANL molecular association, regulation; intracellular localization 12732587; 16373587 20 48 0 +VASP VASP Cytoskeletal; Motility/polarity/chemotaxis P50552 7408 19q13.32 human T278-p 448381 LARRRKAtQVGEKTP carcinogenesis, altered; cell motility, altered; cytoskeletal reorganization; transcription, inhibited 14679200; 17082196; 18637808; 21423205 11 3 19 +IRS1 IRS1 Adaptor/scaffold; Motility/polarity/chemotaxis P35568 3667 2q36.3 human Y612-p 447555 TLHTDDGyMPMSPGV activity, induced; molecular association, regulation cell differentiation, induced; transcription, induced PIK3R1(INDUCES) 11416002; 12525499; 22081023 33 12 294 +Oprm1 MOR-1 GPCR, family 1; Membrane protein, integral; Membrane protein, multi-pass; Receptor, GPCR P33535 25601 1q11 rat T394-p 448128 LENLEAEtAPLP___ receptor desensitization, altered; receptor internalization, altered 10820022; 12860981; 9312100 5 0 0 +PTHLH PTHrP Secreted; Secreted, signal peptide P12272 5744 12p11.22 human T121-p 449879 YKEQPLKtPGKKKKG Parathyroid molecular association, regulation; intracellular localization KPNB1(DISRUPTS) 10373465; 12504010 2 0 0 decreases nuclear accumulation; T121E mutation was localized in the cytoplasm, while a T121A mutation showed nuclear localization. +SKI SKI Cell cycle regulation; Oncoprotein; Transcription, coactivator/corepressor; Ubiquitin conjugating system P12755 6497 1p36.33-p36.32 human S383-p 11145003 LSAFRPWsPAVSASE protein degradation cell cycle regulation; carcinogenesis, induced 26138431 3 10 7 plays a role in chromosomal segregation +Ikbkg IKKG Adaptor/scaffold; Protein kinase, regulatory subunit O88522 16151 X|X A7.3 mouse S375-p 449755 HSFHLALsNQRRSPP activity, inhibited transcription, altered 11971901 1 0 0 NFKB reporter assays +MAP4K1 HPK1 EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, STE; Protein kinase, Ser/Thr (non-receptor) Q92918 11184 19q13.2 human T355-p 23113939 ETRPPANtARLQPPR ubiquitination 24362026 1 0 6 +EHMT2 EHMT2 Amino Acid Metabolism - lysine degradation; EC 2.1.1.43; METHYLTRANSFERASE; Methyltransferase; Methyltransferase, protein lysine Q96KQ7 10919 6p21.33 human K288-sm 1878097301 ERVDSDSkSEVEALT molecular association, regulation; intracellular localization cell cycle regulation; cell growth, induced; transcription, induced PCAF(INDUCES) 30867409 1 0 0 SUMOylated G9a is recruited to E2F1 target gene promoters, EHMT2 is an activator of proliferation and E2F1-target gene expression +TRPC5 TRPC5 Channel, cation; Membrane protein, integral; Membrane protein, multi-pass Q9UL62 7224 Xq23 human S794-p 20834807 SGGARAKsKSVSFNL intracellular localization; activity, inhibited signaling pathway regulation 21734191 1 0 0 +MYH7 MYH7 Motility/polarity/chemotaxis; Motor P12883 4625 14q11.2 human K1195-ac 36314472 TAAALRKkHADSVAE Myosin_tail_1 protein conformation 35502901 0 2 0 +RPS3 RPS3 Apoptosis; EC 4.2.99.18; RNA-binding; Ribosomal; Translation P23396 6188 11q13.4 human S6-p 8046503 __MAVQIsKKRKFVA activity, induced; intracellular localization translation, altered 19059439 2 0 0 important for a cell survival in the stress condition +SNAI1 Snail1 C2H2-type zinc finger protein; Transcription factor O95863 6615 20q13.13 human S112-gl 18416103 PPSPAPSsFSSTSVS protein stabilization; phosphorylation cell motility, induced; transcription, inhibited 20959806 1 1 0 transcriptional suppression of E-cadherin; inhibits O-phosphorylation; induces cell migration and in vivo invasion +TTK TTK Cancer Testis Antigen (CTA); EC 2.7.12.1; KINASE; Kinase, protein; Protein kinase, Other; Protein kinase, dual-specificity (non-receptor) P33981 7272 6q14.1 human T288-p 6370307 SPDCDVKtDDSVVPC protein stabilization; intracellular localization; phosphorylation cell cycle regulation HEC1(INDUCES) 19151762; 24764296; 24798733 4 1 0 +ATG13 ATG13 Autophagy; Vesicle O75143 9776 11p11.2 human S355-p 21127300 DTETVSNsSEGRASP intracellular localization carcinogenesis, altered; autophagy, induced; autophagy, inhibited; signaling pathway regulation 21855797; 24590173; 27259258; 34586834 18 5 0 +Ddx1 DDX1 EC 3.6.4.13; Helicase; RNA-binding Q641Y8 84474 6q15 rat S295-p 1275585100 KALIVEPsRELAEQT DEAD molecular association, regulation RNA(INDUCES) 30295850 1 1 0 insulin translation inhibited +AATF AATF Nucleolus; RNA-binding; Transcription factor Q9NY61 26574 17q12 human S510-p 3753302 KKVDRKAsKGRKLRF TRAUB protein stabilization; molecular association, regulation apoptosis, inhibited; transcription, altered NFkB-p65(INDUCES) DNA(INDUCES) 17157788 1 0 0 +Fus hnRNP P2 DNA-binding; Nuclear receptor co-regulator; Oncoprotein; RNA splicing; RNA-binding; SUMO LIGASE P56959 233908 7|7 F3 mouse Y518-p 50318713 QDRRERPy_______ intracellular localization 37071594 2 0 0 +Ikbkb IKKB EC 2.7.11.10; KINASE; Kinase, protein; Protein kinase, Other; Protein kinase, Ser/Thr (non-receptor) O88351 16150 8|8 A2 mouse S181-p 447489 DQGSLCTsFVGTLQY Pkinase activity, induced; molecular association, regulation; intracellular localization; phosphorylation; enzymatic activity, induced apoptosis, altered; cell differentiation, induced; transcription, induced PPP2R3C(INDUCES) 18497757; 20534585; 20925653; 23332762; 36309088; 36896602; 36914767 76 2 0 induces NFKB phosphorylation; induces IkBa degradation +Trhr TRHR GPCR, family 1; Membrane protein, integral; Membrane protein, multi-pass; Receptor, GPCR Q01717 25570 7q31 rat S360-p 1229701 NYSVIKEsDRFSTEL receptor internalization, altered 17989235; 20345371 3 0 0 +Hmgcr HMGCR EC 1.1.1.34; Endoplasmic reticulum; Membrane protein, integral; Membrane protein, multi-pass; Motility/polarity/chemotaxis; Oxidoreductase; Secondary Metabolites Metabolism - terpenoid backbone biosynthesis Q01237 15357 13 D1|13 50.65 cM mouse K89-ub 55607400 NLRQLGSkYILGIAG Sterol-sensing protein degradation 27129778 2 0 0 +Pacsin1 PACSIN1 Adaptor/scaffold Q61644 23969 17|17 A3.3 mouse S76-p 23940709 EKGPQYGsLERAWGA FCH protein conformation 22355135 1 2 0 +PARP10 PARP10 EC 2.4.2.30; Nucleolus; Transferase Q53GL7 84875 8q24.3 human T101-p 12526705 QGLPPGTtPQRLEQH molecular association, regulation; intracellular localization transcription, altered; cell growth, altered POLR2A(INDUCES) 16455663 1 0 0 PARP10 T101 phosphorylation is associated with actively growing cells. +IGFBP3 IGFBP3 Cell development/differentiation; Secreted; Secreted, signal peptide P17936 3486 7p12.3 human S183-p 471397 KKGHAKDsQRYKVDY intracellular localization apoptosis, altered; cell growth, induced; apoptosis, inhibited 17108124; 23557743 2 0 0 +UBE2I UBC9 EC 6.3.2.-; EC 6.3.2.19; Ligase; Nuclear receptor co-regulator; SUMO LIGASE; SUMO conjugating system; SUMO ligase; UBIQUITIN LIGASE; Ubiquitin conjugating system; Ubiquitin ligase P63279 7329 16p13.3 human S71-p 3803343 FKDDYPSsPPKCKFE UQ_con molecular association, regulation; protein stabilization; enzymatic activity, induced PLK1(INDUCES) 22407595; 22509284; 29166606 4 6 8 +FLOT1 FLOT1 Adaptor/scaffold O75955 10211 6p21.33 human S315-p 18750500 QAEAEAAsVRMRGEA intracellular localization; protein conformation endocytosis, induced; cell motility, inhibited 21399631; 31753918 2 0 0 decrease angiogenesis +Prkcd PKCD EC 2.7.11.13; KINASE; Kinase, protein; Nuclear receptor co-regulator; Protein kinase, AGC; Protein kinase, Ser/Thr (non-receptor); Protein kinase, tyrosine (non-receptor); Tumor suppressor P09215 170538 16p16 rat Y64-p 447581 STFDAHIyEGRVIQI intracellular localization apoptosis, induced 24569990 7 3 31 +STK4 MST1 Autophagy; EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, STE; Protein kinase, Ser/Thr (non-receptor) Q13043 6789 20q13.12 human T120-p 11496001 IIRLRNKtLTEDEIA Pkinase molecular association, regulation; intracellular localization; enzymatic activity, inhibited; phosphorylation carcinogenesis, induced; apoptosis, altered; cell growth, induced; transcription, induced; signaling pathway regulation AR(DISRUPTS) 19940129; 22619175 3 0 0 regulates autophosphorylation of MST1 T183; Hippo signaling pathway +Pth1r PTHR GPCR, family 2; Membrane protein, integral; Membrane protein, multi-pass; Receptor, GPCR P25961 56813 8q32 rat S493-p 2853105 KARSGSSsYSYGPMV receptor internalization, altered; activity, inhibited 11773434; 18577695 4 2 0 +SLC14A2 SLC14A2 Membrane protein, integral; Membrane protein, multi-pass; Transporter; Transporter, SLC family Q15849 8170 18q12.3 human S490-p 2813500 WSSIRRRsKVFGKGE ubiquitination 24133116 6 0 0 mutant reduces forskolin induced SLC14AZ ubiquitination +CDC7 CDC7 EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, Other; Protein kinase, Ser/Thr (non-receptor) O00311 8317 1p22.2-p22.1 human T503-p 23092189 KASCLVQtPPGQYSG protein degradation; ubiquitination 27611229 1 7 2 +NUP98 NUP98 iso2 Motility/polarity/chemotaxis; Nucleoporin P52948-2 4928 11p15.4 human S568-p 18330802 GLDDDEPsLANGAFM intracellular localization 21335236 1 1 0 as multiple sites (13PM) mutant +MDC1 MDC1 Cell cycle regulation Q14676 9656 6p21.33 human K1977-ub 25091200 VTDPEQEkNFGFSLQ molecular association, regulation; intracellular localization DNA repair, induced RAP80(INDUCES) 21857162 1 0 0 focus formation of RAP80-BRCA1 complex to DSBs for repair +ENSA ENSA Inhibitor; Protein phosphatase, regulatory subunit O43768 2029 1q21.3 human S67-p 455934 KGQKYFDsGDYNMAK Endosulfine molecular association, regulation; enzymatic activity, inhibited cell cycle regulation PPP2CA(INDUCES) 24391510; 27889260; 32085646 5 68 47 +TBXA2R TXA2-R iso2 GPCR, family 1; Membrane protein, integral; Membrane protein, multi-pass; Receptor, GPCR P21731-2 6915 19p13.3 human T332-p 18790000 TRPRRSLtLWPSLEY receptor desensitization, altered 14530262 1 0 0 +RHOA RHOA G protein; G protein, monomeric; G protein, monomeric, Rho; Motility/polarity/chemotaxis; Oncoprotein P61586 387 3p21.31 human S88-p 53332703 LMCFSIDsPDSLENI Ras activity, induced; intracellular localization cytoskeletal reorganization ROCK1(INDUCES) 26816343 1 0 0 enhanced actin stress fiber formation, distributed in the cytoplasm with or without EGF stimulation +KAT5 Tip60 ACETYLTRANSFERASE; Acetyltransferase; EC 2.3.1.48; Nuclear receptor co-regulator; Nucleolus Q92993 10524 11q13.1 human S86-p 448826 TKNGLPGsRPGSPER activity, induced; acetylation; protein stabilization DNA repair, induced; apoptosis, induced; transcription, induced; transcription, altered 16103124; 21658600; 30297459; 30704899 7 31 5 +STIM1 STIM1 Calcium-binding; Endoplasmic reticulum; Membrane protein, integral Q13586 6786 11p15.4 human S575-p 468876 LVEKLPDsPALAKKA molecular association, regulation; intracellular localization; activity, inhibited; protein conformation cell motility, induced EB1(DISRUPTS); CDON(INDUCES) 22298426; 25447552; 25562429; 28935720 9 69 13 GPER activation to inhibit SOCE; promotes myoblast differentiation; accelerates cell migration in wound-healing assays; NFAT translocation to the nucleus, multimerization +FCER1G FCER1G Membrane protein, integral; Receptor, misc. P30273 2207 1q23.3 human Y65-p 451737 YEKSDGVyTGLSTRN ITAM phosphorylation 27630214 4 15 593 S69 phosphorylation inhibits Y65 phosphorylation +TRPC6 TRPC6 Channel, cation; Membrane protein, integral; Membrane protein, multi-pass Q9Y210 7225 11q22.1 human T70-p 470868 RLAHRRQtVLREKGR activity, inhibited cell motility, inhibited 19961855; 23814119; 24740790 11 2 6 +POLH POLH DNA repair, damage; EC 2.7.7.7; Transferase Q9Y253 5429 6p21.1 human T617-p 5024700 SKSVLEVtQKATPNP intracellular localization DNA repair, induced; cell growth, altered 18946034; 35339488 2 0 0 +JUND JunD Motility/polarity/chemotaxis; Transcription factor P17535 3727 19p13.11 human S100-p 456168 LGLLKLAsPELERLI Jun molecular association, regulation transcription, induced MEN1(DISRUPTS) 22327296 5 63 12 +RGS18 RGS18 GAP; GAP, RGS Q9NS28 64407 1q31.2 human S216-p 4772683 PTNLRRRsRSFTCNE molecular association, regulation signaling pathway regulation 14-3-3 gamma(DISRUPTS) 22234696; 24244663 2 4 0 inhibits RGS18 binding to 14-3-3 gamma via S49; Ca 2+ signaling; constitutive binding to 14-3-3 gamma; followed by dephosphorylation of S49 and S218 +Tnfaip3 TNFAIP3 Apoptosis; DEUBIQUITINASE; EC 3.4.19.12; Protease; UBIQUITIN LIGASE; Ubiquitin conjugating system; Ubiquitin ligase Q60769 21929 10 A3|10 8.08 cM mouse S381-p 487535 EPSTPQLsLMDIKCE molecular association, regulation; intracellular localization TNIP1(INDUCES) 29203883 5 10 0 recruitment into TNF-RSC +MLYCD MLYCD Carbohydrate Metabolism - propanoate; EC 4.1.1.9; Lyase; Other Amino Acids Metabolism - beta-alanine O95822 23417 16q23.3 human S204-p 41196500 LERVTWHsPCEVLQK MCD protein conformation; enzymatic activity, induced 26004805 1 0 0 +MAST1 MAST1 EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, AGC; Protein kinase, Ser/Thr (non-receptor) Q9Y2H9 22983 19p13.13 human K317-ub 964526012 AKEGHLVkTDIPRYI DUF1908 protein degradation 31449053 1 2 0 proteasomal degradation sensitizes cisplatin-resistant cells to cisplatin +FOXA2 FOXA2 DNA-binding; Transcription factor Q9Y261 3170 20p11.21 human S107-p 22825100 AGMGPHLsPSLSPLG Forkhead_N carcinogenesis, induced; cell growth, induced; transcription, inhibited; signaling pathway regulation 22196886 1 1 0 +FLT3 FLT3 EC 2.7.10.1; KINASE; Kinase, protein; Membrane protein, integral; Oncoprotein; Protein kinase, TK; Protein kinase, tyrosine (receptor) P36888 2322 13q12.2 human Y591-p 448190 SSDNEYFyVDFREYE molecular association, regulation; enzymatic activity, induced; phosphorylation cell growth, altered Fyn(INDUCES) 11971190; 16103085; 16627759; 26848862 14 0 0 The double mutation Y589/591F has a slower growth rate (this is in the ligand-independent, constitutive active allele). +Mc2r MC2R GPCR, family 1; Membrane protein, integral; Membrane protein, multi-pass; Receptor, GPCR Q64326 17200 18 E2|18 41.89 cM mouse S208-p 456021 RSHARKIsTLPRTNM 7tm_1 receptor desensitization, altered 12456795 1 0 0 +UBE2I UBC9 EC 6.3.2.-; EC 6.3.2.19; Ligase; Nuclear receptor co-regulator; SUMO LIGASE; SUMO conjugating system; SUMO ligase; UBIQUITIN LIGASE; Ubiquitin conjugating system; Ubiquitin ligase P63279 7329 16p13.3 human K65-ac 11316163 FKLRMLFkDDYPSSP UQ_con sumoylation; molecular association, regulation; protein conformation CAPN2(DISRUPTS); CBP(DISRUPTS); ELK1(DISRUPTS) 23395904; 29234076 2 5 0 disruption of the binding affinity of Ubc9 to NDSM residues, such as in Calpain2, Elk1, and CBP, but not with non-NDSM +Glp1r GLP1R GPCR, family 2; Membrane protein, integral; Membrane protein, multi-pass; Receptor, GPCR P32301 25051 20p12 rat S432-p 451367 LNIQRDSsMKPLKCP receptor desensitization, altered 8702711 1 0 0 +LEO1 LEO1 Transcription regulation Q8WVC0 123169 15q21.2 human S88-p 83111281 SERSDNRsEASERSD molecular association, regulation; intracellular localization carcinogenesis, inhibited; cell growth, inhibited; apoptosis, induced; transcription, inhibited; signaling pathway regulation CTNNB1(DISRUPTS) 30305722 1 2 0 +Cdkn1b p27Kip1 Cell cycle regulation; Inhibitor; Oncoprotein; Protein kinase, regulatory subunit P46414 12576 6 G1|6 65.77 cM mouse T183-p 23128659 DGSPNAGtVEQTPKK intracellular localization carcinogenesis, induced; cell growth, induced 23602409 1 1 1 +Homer2 HOMER2 Actin-binding; Adaptor/scaffold Q9QWW1 26557 7|7 D3 mouse S117-p 3893303 ARLARDKsQEKTETS molecular association, regulation mGluR5(DISRUPTS) 36973011 1 0 6 +MAPRE3 EB3 Microtubule-binding Q9UPY8 22924 2p23.3 human S162-p 2023813 TAVPQRTsPTGPKNM molecular association, regulation; protein conformation cell adhesion, induced; cytoskeletal reorganization PPP3CA(DISRUPTS) 23159740 1 24 1 inhibits persistent microtubule growth and supports adherens junctions integrity; destabilizes EB3 dimers +Relb RELB Transcription factor Q04863 19698 7 A3|7 9.93 cM mouse K308-ub 3055602 LLCDKVQkEDISVVF RHD_dimer transcription, induced 18620544 1 0 0 +Dcc DCC Immunoglobulin superfamily; Membrane protein, integral; Receptor, misc.; Tumor suppressor Q63155 25311 18q12.1 rat Y1418-p 454409 TEDPASVyEQDDLSE Neogenin_C cell growth, altered 15557120; 18253061 5 0 0 +Gjd2 GJD2 Cell adhesion; Channel, misc.; Membrane protein, integral; Membrane protein, multi-pass O54851 14617 2|2 E4 mouse S293-p 471387 GAQAKRKsVYEIRNK activity, induced; activity, inhibited neural plasticity 16956882; 32547367 4 3 0 adaptation to ambient light conditions; induces coupling through gap junctions; regulating gap junction communication +NCOA1 SRC-1 ACETYLTRANSFERASE; Acetyltransferase; DNA-binding; EC 2.3.1.48; Nuclear receptor co-regulator; Oncoprotein; Transcription, coactivator/corepressor Q15788 8648 2p23.3 human T1426-p 18958502 KPTSGPQtPQAQQKS transcription, induced 21550420 1 0 0 +ZNF281 ZNF281 C2H2-type zinc finger protein; DNA-binding; Transcription factor Q9Y2X9 23528 1q32.1 human S638-p 31881319 PRVDLHTsGEHSELV protein degradation; ubiquitination FBW1B(INDUCES) 29179460 1 1 0 +NHE-3 NHE3 Membrane protein, integral; Membrane protein, multi-pass; Transporter; Transporter, SLC family P26432 100009430 rabbit S719-p 3496800 KERELELsDPEEAPD activity, induced; molecular association, regulation; intracellular localization; activity, inhibited SNX27(INDUCES) 18614797; 28495796 3 3 0 +Nr3c1 GR DNA-binding; Mitochondrial; Nuclear receptor; Transcription factor P06536 24413 18p11 rat S246-p 451796 LIDENLLsPLAGEDD GCR activity, induced; activity, inhibited transcription, induced; transcription, altered 11139390; 15292225; 18304804; 18337589; 9482836 39 9 1 modulates sumoylation at K297 and K313; Inhibitory of GR mediated transcription by JNK was weak consistent with earlier data that the inhibitory effect of JNK is atributable to S246 phosphorylation, which is not present in the GR525-795 construct. ; induces hormone-dependent recruitment of GR to promoters (of tat, sult and gliz genes) +NIN NIN Cytoskeletal; Microtubule-binding Q8N4C6 51199 14q22.1 human K1680-sm 12004429 QQENHLLkDELEKMK intracellular localization 16154161 1 0 0 +TP63 p63 DNA-binding; Transcription factor Q9H3D4 8626 3q28 human S43-p 27937107 YRSTMSQsTQTNEFL molecular association, regulation transcription, inhibited p300(DISRUPTS) 23589370 1 1 0 +SUV39H1 SUV39H1 Amino Acid Metabolism - lysine degradation; EC 2.1.1.43; METHYLTRANSFERASE; Methyltransferase; Methyltransferase, protein lysine O43463 6839 Xp11.23 human K266-ac 1876066700 RTLEKIRkNSFVMEY SET enzymatic activity, inhibited transcription, inhibited 18004385 1 0 0 +HOXA10 HOXA10 DNA-binding; Transcription factor P31260 3206 7p15.2 human K339-ac 31094515 TAKSGRKkRCPYTKH Homeodomain protein degradation transcription, inhibited; cell adhesion, inhibited 24037888 1 0 0 +FLT3 FLT3 EC 2.7.10.1; KINASE; Kinase, protein; Membrane protein, integral; Oncoprotein; Protein kinase, TK; Protein kinase, tyrosine (receptor) P36888 2322 13q12.2 human Y793-p 7996202 EDLLCFAyQVAKGME PK_Tyr_Ser-Thr molecular association, regulation GRB10(INDUCES) 23246379 2 0 1 +Aurka AurA EC 2.7.11.1; KINASE; Kinase, protein; Oncoprotein; Protein kinase, Other; Protein kinase, Ser/Thr (non-receptor) P97477 20878 2 H3|2 94.84 cM mouse T279-p 448784 APSSRRTtMCGTLDY Pkinase intracellular localization; phosphorylation; enzymatic activity, induced neural plasticity; carcinogenesis, induced; chromatin organization, altered; transcription, induced; signaling pathway regulation 18677115; 33439240; 34031150; 34772938; 35771632 66 12 7 +Gap43 GAP43 Cell surface P06837 14432 16 B4|16 28.37 cM mouse T172-p 449106 VTDAAATtPAAEDAA Neuromodulin cell growth, induced; cytoskeletal reorganization 33832520 2 16 3 +Gphn gephyrin Adaptor/scaffold; EC 2.10.1.1; EC 2.7.7.75 Q8BUV3 268566 12|12 C3 mouse S194-p 478375 PSPPPPLsPPPTTSP molecular association, regulation PIN1(INDUCES) 17347650 3 45 0 +Polr2a POLR2A EC 2.7.7.48; EC 2.7.7.6; Nucleotide Metabolism - purine; Nucleotide Metabolism - pyrimidine; Transcription initiation complex; Transferase P08775 20020 11 B3|11 42.86 cM mouse K1887-ub 2134722 TYSPTTPkYSPTSPT protein degradation 17526739 1 1 0 +Foxg1 FOXG1 DNA-binding; Nuclear receptor co-regulator; Transcription factor Q60987 15228 12 B3|12 21.78 cM mouse T271-p 482881 KLRRRSTtSRAKLAF intracellular localization apoptosis, inhibited; transcription, induced 21228151; 26523971 3 0 0 +ING1 ING1 iso2 Tumor suppressor Q9UK53-2 3621 13q34 human S199-p 18010889 AKAEREAsPADLPID sumoylation 24903338 1 2 0 S199-p promotes SUMOylation of K193 +RUNX3 AML2 DNA-binding; Transcription factor Q13761 864 1p36.11 human T155-p 6097703 KSFTLTItVFTNPTQ Runt protein stabilization; intracellular localization cell cycle regulation; transcription, altered 18767071 1 1 0 +Kcnb2 Kv2.2 Channel, potassium; Membrane protein, integral; Membrane protein, multi-pass Q63099 117105 5q11 rat S481-p 15720997 ESANIKDsVDDNHLS Kv2channel activity, inhibited neural plasticity 34542799 1 2 0 +PDGFRB PDGFRB EC 2.7.10.1; KINASE; Kinase, protein; Membrane protein, integral; Oncoprotein; Protein kinase, TK; Protein kinase, tyrosine (receptor) P09619 5159 5q32 human S712-p 23130549 SDKRRPPsAELYSNA PK_Tyr_Ser-Thr enzymatic activity, inhibited; phosphorylation signaling pathway regulation 29935031 1 1 2 regulates MEK/ERK and PI3K/AKT mediated pathways, inhibits phosphorylation of Y751 +RCC1 RCC1 Cell cycle regulation; GEF; GEF, Ras P18754 1104 1p35.3 human S29-p 2850004 KVKVSHRsHSTEPGL molecular association, regulation KPNA4(DISRUPTS) 18568422 1 0 0 +Foxo1 FOXO1A DNA-binding; Nuclear receptor co-regulator; Oncoprotein; Transcription factor G3V7R4 84482 2q26 rat S313-p 449113 TFRPRTSsNASTISG molecular association, regulation; acetylation; intracellular localization transcription, induced DNA(DISRUPTS) 33560565 29 5 27 H4 acetylation +PPP1R2 PPP1R2 Inhibitor; Motility/polarity/chemotaxis; Protein phosphatase, regulatory subunit P41236 5504 3q29 human S44-p 2231000 DEELSKKsQKWDEMN cell cycle regulation PPP1CA(DISRUPTS) 18250156 2 0 0 in response to IR-induced DNA damage +TNK2 Ack EC 2.7.10.2; EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, TK; Protein kinase, tyrosine (non-receptor) Q07912 10188 3q29 human Y860-p 448884 KVSSTHYyLLPERPS protein conformation; phosphorylation; enzymatic activity, induced 36178070 3 19 222 +CFTR CFTR Channel, chloride; EC 3.6.3.49; Hydrolase; Membrane protein, integral; Membrane protein, multi-pass; Transporter; Transporter, ABC family P13569 1080 7q31.2 human T682-p 2907505 APVSWTEtKKQSFKQ CFTR_R activity, induced; protein conformation; activity, inhibited 12588899; 14695900; 32123855 3 0 0 +Chpt1 CHPT1 EC 2.7.8.2; Lipid Metabolism - ether lipid; Lipid Metabolism - glycerophospholipid; Membrane protein, integral; Membrane protein, multi-pass; Transferase Q8C025 212862 10|10 C1 mouse K283-ub 12718510 ILAIMIYkKSATNMF protein degradation; enzymatic activity, inhibited 20018880 1 0 0 +SLC6A9 GlyT1 iso3 Membrane protein, integral; Membrane protein, multi-pass; Transporter, SLC family P48067-3 6536 1p34.1 human K633-ub 7761221 VQPLHPDkAQIPIVG receptor internalization, induced; protein degradation endocytosis, induced 19473961 1 5 1 +HOXA10 HOXA10 DNA-binding; Transcription factor P31260 3206 7p15.2 human K338-ac 31094516 LTAKSGRkKRCPYTK Homeodomain protein degradation transcription, inhibited; cell adhesion, inhibited 24037888 1 0 0 +IRF6 IRF6 DNA-binding; Transcription factor O14896 3664 1q32.2 human S424-p 27451041 GSVRLQIsTPDIKDN activity, induced; protein conformation transcription, induced 24872416; 25246526 3 9 0 +PDX1 PDX1 DNA-binding; Transcription factor P52945 3651 13q12.2 human S66-p 458402 QGSPPDIsPYEVPPL transcription, induced 12810726 3 0 0 +ABI3 ABI3 Adaptor/scaffold Q9P2A4 51225 17q21.32 human S216-p 4755287 FSLASAGsAEGVGGA protein stabilization; molecular association, regulation carcinogenesis, induced; cell motility, induced FAT10(INDUCES) 36926204 1 4 0 +PRPF19 PRPF19 EC 6.3.2.-; EC 6.3.2.19; Ligase; RNA splicing; Spliceosome; UBIQUITIN LIGASE; Ubiquitin conjugating system; Ubiquitin ligase Q9UMS4 27339 11q12.2 human S149-p 25247501 VPQAVPSsQPSVVGA DNA repair, induced; apoptosis, inhibited 22529335 1 1 0 cell life span extension +SMN1 SMN RNA processing; RNA-binding Q16637 6606 5q13.2 human Y127-p 1022804 RETCVVVyTGYGNRE SMN molecular association, regulation; intracellular localization coilin(INDUCES) 24602413 1 2 0 +Shtn1 SHOT1 Unknown function A0MZ67 292139 1q55 rat S101-p 4761847 NKTLKRIsMLYMAKL molecular association, regulation; intracellular localization cell motility, induced; cytoskeletal reorganization Cortactin(INDUCES) 23453953; 26261183 4 5 0 SHOT1 phosphorylation increases binding affinity with F-Actin and induces axonal outgrowth; signal?force transduction in axon outgrowth +PFKFB3 PFKFB3 Carbohydrate Metabolism - fructose and mannose; EC 2.7.1.105; EC 3.1.3.46; KINASE; Kinase, other; Motility/polarity/chemotaxis; PHOSPHATASE; Phosphatase (non-protein) Q16875 5209 10p15.1 human S478-p 9318263 TKKPRINsFEEHVAS protein stabilization; ubiquitination; enzymatic activity, induced carcinogenesis, induced; cell motility, induced; cell growth, induced 33931981 2 6 5 promotes glycolysis and Paclitaxel resistance; inhibits ubiquitination +EIF4ENIF1 4E-T Karyopherin; Nuclear import; Translation Q9NRA8 56478 22q12.2 human S693-p 3213600 ASITSMLsPSFTPTS EIF4E-T molecular association, regulation 4E-T(INDUCES) 22966201 1 6 0 required for processing bodies (PBs or P bodies) assembly +PLSCR1 PLSCR1 Calcium-binding; Membrane protein, integral O15162 5359 3q24 human Y69-p 2915403 PVPNQPVyNQPVYNQ molecular association, regulation; intracellular localization carcinogenesis, induced; cell growth, induced; transcription, induced SHC1(INDUCES); STAT3(INDUCES) DNA(INDUCES) 12871937; 32292520 3 0 0 induces binding to STAT1 promoter and STAT1 expression +SPHK2 SPHK2 EC 2.7.1.91; Kinase, lipid; Lipid Metabolism - sphingolipid Q9NRA0 56848 19q13.33 human S421-p 486447 SPLHRSVsDLPLPLP intracellular localization 17635916 1 0 0 regulation of nuclear shuttling +DEPDC5 DEPDC5 Unknown function O75140 9681 22q12.2-q12.3 human S1530-p 3845300 QQRRRRNsTSSTNQN DEPDC5_CTD phosphorylation carcinogenesis, induced; cell growth, induced 31548394 1 8 19 induces phosphorylation of mTORC1 substrates +Pdc phosducin G protein regulator, misc. P20942 25343 13q21 rat S106-p 10431701 QDMHQKLsFGPRYGF Phosducin molecular association, regulation G-gamma 2(DISRUPTS); G-beta 1(DISRUPTS) 11331285 1 0 0 +APP APP iso4 Apoptosis; Cell surface; Membrane protein, integral; Receptor, misc.; Transcription factor P05067-4 351 21q21.3 human Y682-p 448202 SKMQQNGyENPTYKF APP_amyloid molecular association, regulation; intracellular localization signaling pathway regulation Fe65(DISRUPTS); Abl iso4(NOT_REPORTED) 11279131; 24086696 14 20 864 APP both phosphorylated and not phosphorylated at Y682 interacts with Abl; diminished nuclear signaling +Dync1i1 DYNC1I1 Microtubule-binding; Motility/polarity/chemotaxis; Motor Q63100 29564 4q13 rat S100-p 6006907 PTPMSPSsKSVSTPS molecular association, regulation cytoskeletal reorganization dynactin 1(DISRUPTS) 11340075; 19061245 3 1 0 +GAPDH GAPDH Carbohydrate Metabolism - glycolysis and gluconeogenesis; EC 1.2.1.12; Oxidoreductase P04406 2597 12p13.31 human K254-ac 474649 CRLEKPAkYDDIKKV Gp_dh_C enzymatic activity, induced carcinogenesis, induced; cell growth, induced 24362262 2 8 10 +Mfn2 MFN2 Cell cycle regulation; Cytoskeletal; EC 3.6.5.-; Hydrolase; Membrane protein, integral; Membrane protein, multi-pass; Mitochondrial Q8R500 64476 5q36 rat S442-p 4746700 AEEIRRLsVLVDEYQ cell cycle regulation; autophagy, induced; apoptosis, inhibited; cell growth, altered 20303493; 36682578 6 2 0 induces mitophagy +TCF3 E2A Cell development/differentiation; DNA-binding; Oncoprotein; Transcription factor P15923 6929 19p13.3 human S245-p 455906 PMLGGGSsPLPLPPG cell growth, altered 11114297 1 0 0 +ID3 ID3 DNA-binding; Transcription, coactivator/corepressor Q02535 3399 1p36.12 human Y48-p 35524904 LDDMNHCySRLRELV HLH protein stabilization 25090023 1 1 0 regulates vascular EC survival and growth of microvascular lesions +Cryab CRYAB Chaperone; Heat shock protein P23927 12955 9 A5.3|9 27.75 cM mouse S19-p 447728 RPFFPFHsPSRLFDQ Crystallin protein degradation 29088822 26 16 2 +VIPR1 VIPR1 GPCR, family 2; Membrane protein, integral; Membrane protein, multi-pass; Motility/polarity/chemotaxis; Receptor, GPCR P32241 7433 3p22.1 human T429-p 455876 SGGSNGAtCSTQVSM receptor desensitization, altered 16554109 2 0 0 +BCL2L1 Bcl-xL Apoptosis; Autophagy; Membrane protein, integral; Mitochondrial Q07817 598 20q11.21 human T115-p 448162 LTSQLHItPGTAYQS Bcl-2 apoptosis, induced 10617621 2 0 0 +CDKN1B p27Kip1 Cell cycle regulation; Inhibitor; Oncoprotein; Protein kinase, regulatory subunit P46527 1027 12p13.1 human T157-p 448645 GIRKRPAtDDSSTQN protein degradation; molecular association, regulation; intracellular localization; phosphorylation cell cycle regulation; cell motility, induced; apoptosis, inhibited; transcription, induced; cytoskeletal reorganization; cell growth, altered KPNA1(DISRUPTS); 14-3-3 epsilon(INDUCES); CCND1(INDUCES); CDK4(INDUCES); JAK2(INDUCES); 14-3-3 beta(INDUCES); 14-3-3 theta(INDUCES); KPNA5(INDUCES); 14-3-3 gamma(INDUCES) 12244301; 12244302; 12244303; 15057270; 15579463; 15743786; 16790529; 18519679; 18570873; 18593906; 18710949; 19118035; 22139837; 23707388; 25684140; 26684356; 26701207 25 0 1 +CDK5R1 CDK5R1 Protein kinase, regulatory subunit Q15078 8851 17q11.2 human T138-p 471393 PAVTSAGtPKRVIVQ CDK5_activator protein degradation; molecular association, regulation; protein stabilization; protein conformation; activity, inhibited cytoskeletal reorganization; cell growth, altered 17121855; 18326489; 20976519; 26631721 8 1 0 augments its F-actin bundling activity, disrupts microtubule binding; regulates microtubule-polymerizing and binding activities +Syk Syk EC 2.7.10.2; KINASE; Kinase, protein; Protein kinase, TK; Protein kinase, tyrosine (non-receptor) Q64725 25155 17p14 rat Y317-p 447658 STVSFNPyEPTGGAW enzymatic activity, inhibited 10605028; 20828828 21 30 1019 +STK3 MST2 Autophagy; EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, STE; Protein kinase, Ser/Thr (non-receptor) Q13188 6788 8q22.2 human T384-p 3195191 GTMKRNAtSPQVQRP molecular association, regulation; ubiquitination; intracellular localization; enzymatic activity, inhibited; phosphorylation cell cycle regulation; carcinogenesis, induced; apoptosis, altered; signaling pathway regulation MST2(DISRUPTS); RASSF1(DISRUPTS); RAF1(INDUCES) 20086174; 37739411 2 8 36 TRIM69 regulates centrosome dynamics and mitotic progression and centrosome amplification, regulates centrosome clustering, promotes triple-negative breast cancer; TRIM69A regulates MST2 ubiquitination and intracellular localization +Sort1 SORT1 Membrane protein, integral; Receptor, misc. Q6PHU5 20661 3|3 F2.3-F3 mouse K812-ub 34666300 LDSTSHAkSGYHDDS protein degradation 24986865 1 0 0 +Syt12 SYT12 Membrane protein, integral; Vesicle Q920N7 171180 19|19 A mouse S97-p 473040 GPPSRKGsLSIEDTF neural plasticity 23739973 2 2 0 induction of hippocampal mossy-fiber LTP +Lig4 LIG4 EC 6.5.1.1; Ligase Q8BTF7 319583 8|8 A1.1 mouse S650-p 454069 HLKAPNLsNVNKVSN protein stabilization 15194694 1 0 0 +RRAD RRAD G protein; G protein, monomeric; G protein, monomeric, RGK P55042 6236 16q22.1 human S214-p 457394 LVRSREVsVDEGRAC Ras molecular association, regulation Calmodulin(INDUCES) 9677319 1 0 0 +KRT8 K8 Cytoskeletal P05787 3856 12q13.13 human K393-ac 1983600 IEIATYRkLLEGEES Filament cytoskeletal reorganization 18203277 1 5 15 intermediate filament stabilization +TRPV6 TRPV6 Channel, calcium; Membrane protein, integral; Membrane protein, multi-pass Q9H1D0 55503 7q34 human T742-p 11381600 WERLRQGtLRRDLRG activity, induced; molecular association, regulation; activity, inhibited carcinogenesis, induced Calmodulin(INDUCES) 11248124; 32186440 2 0 0 +ORAI1 ORAI1 Channel, calcium; Membrane protein, integral; Membrane protein, multi-pass Q96D31 84876 12q24.31 human S34-p 48990000 SRRSRRRsGDGEPPG activity, inhibited cell growth, inhibited; cell motility, inhibited 31036819; 31652779 3 0 0 +IQGAP1 IQGAP1 GAP; GAP, Ras; Motility/polarity/chemotaxis P46940 8826 15q26.1 human K556-ub 15390899 LDEGDAQkTLQALQI molecular association, regulation CDC42(DISRUPTS); RAC1(DISRUPTS); CDC42(INDUCES); RAC1(INDUCES) 32094223 1 4 6 K556KR compared to WT; 6KR mutant compared to WT +CASP8 CASP8 Apoptosis; EC 3.4.22.61; Protease Q14790 841 2q33.1 human Y380-p 460647 TDSEEQPyLEMDLSS Peptidase_C14 molecular association, regulation; intracellular localization; protein processing; enzymatic activity, inhibited; phosphorylation carcinogenesis, induced; apoptosis, altered; cell motility, induced; apoptosis, induced; transcription, induced; cell growth, induced; apoptosis, inhibited; cell motility, altered; cell adhesion, altered IKKA(INDUCES); IKKB(INDUCES); Src(INDUCES); PIK3R1(NOT_REPORTED); IkB-alpha(INDUCES); NFkB-p65(INDUCES); PIK3R1(INDUCES) 16619028; 18086677; 18089778; 18216014; 18974049; 19851329; 27109099; 34367939; 36460775 10 3 35 induces NFKB phosphorylation; enhances Src phosphorylation; ; phosphorylation of this site in pro-caspase-8 form supresses protein autocleavage and apoptosis; localized to lamella in adherent cells leading to enhanced migration; impeding native CD95 DISC function +HLA-B HLAB Immunoglobulin superfamily; Membrane protein, integral P01889 3106 6p21.33 human K340-ub 2793002 RRKSSGGkGGSYSQA MHC_I_C receptor internalization, induced; protein degradation 18083706 1 3 26 MHC-I down-regulation of HLAB from the cell surface in cancer cells +Ctnnb1 CTNNB1 Actin-binding; Cell adhesion; Motility/polarity/chemotaxis; Nuclear receptor co-regulator; Oncoprotein; Transcription factor Q9WU82 84353 8q32 rat K49-ac 458938 TAPSLSGkGNPEEED protein degradation; activity, inhibited transcription, induced 36470978 17 0 0 Sirt3 mainly mediated ?-catenin K49 deacetylation and induced ubiquitin-dependent degradation, supressing pro?brotic downstream target gene expression +LZTS2 LZTS2 Nuclear export Q9BRK4 84445 10q24.31 human S273-p 25299402 TGPSHSDsGRSSSSK protein degradation; molecular association, regulation; ubiquitination; phosphorylation carcinogenesis, induced; cell motility, induced; cell growth, induced; signaling pathway regulation BTRC(INDUCES) 33420362 1 0 1 induces phosphorylation of downstream targets thus inducing the PI3K/AKT signaling pathway +ANAPC1 APC1 Cell cycle regulation; Ubiquitin conjugating system Q9H1A4 64682 2q13 human S364-p 3212076 ALGVHSFsGVQRFNI activity, induced 27120157 1 5 0 +TAOK1 TAO1 EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, STE; Protein kinase, Ser/Thr (non-receptor) Q7L7X3 57551 17q11.2 human T643-p 3627518 EELNKRQtQKDLEHA activity, induced cell cycle regulation 17396146 1 0 0 +PRPS2 PRPS2 Carbohydrate Metabolism - pentose phosphate pathway; EC 2.7.6.1; Kinase, other; Nucleotide Metabolism - purine P11908 5634 Xp22.2 human S180-p 18014264 GGAKRVTsIADRLNV protein conformation; activity, inhibited cell growth, inhibited 29074724 1 5 0 tumor cell growth inhibited; converts PRPS1/2 hexamers to monomers +NOTCH1 Notch 1 Membrane protein, integral; Motility/polarity/chemotaxis; Oncoprotein; Receptor, misc.; Transcription factor P46531 4851 9q34.3 human S1900-p 20831302 GGLETGNsEEEEDAP Ank_2 molecular association, regulation; activity, inhibited; phosphorylation transcription, induced; transcription, inhibited RBPJ(INDUCES) DNA(DISRUPTS) 21685388; 24220241 2 0 0 +IFNAR1 IFNAR1 Membrane protein, integral; Receptor, cytokine P17181 3454 21q22.11 human S535-p 454418 SSQTSQDsGNYSNED protein degradation; molecular association, regulation; ubiquitination signaling pathway regulation BTRC(NOT_REPORTED) 15337770; 16551269; 21695243; 21865166; 26676772 8 0 0 regulation of PERK1 pathway; attenuation of INF alpha/beta signaling +APEX1 APE1 DNA repair, damage; DNA-binding; Deoxyribonuclease; EC 4.2.99.18; Endoplasmic reticulum; Hydrolase; Lyase; Nuclear receptor co-regulator; Nucleolus; Transcription, coactivator/corepressor P27695 328 14q11.2 human K31-ac 15207804 KKSKTAAkKNDKEAA acetylation; molecular association, regulation; intracellular localization; protein conformation; enzymatic activity, induced DNA repair, induced; cell growth, induced; cell growth, inhibited NPM1(DISRUPTS); XRCC1(INDUCES) RNA(DISRUPTS) 20699270; 22918947; 27994014 4 2 0 +FBXW7 FBXW7 Motility/polarity/chemotaxis; Nucleolus; UBIQUITIN LIGASE; Ubiquitin conjugating system; Ubiquitin ligase Q969H0 55294 4q31.3 human S349-p 25126711 IKPGFIHsPWKSAYI protein degradation cytoskeletal reorganization 22399798 1 1 0 Phosphorylation prevents ubiquitin-dependent degradation of cyclin E and subsequent centriole duplication. +FBXL20 FBXL20 UBIQUITIN LIGASE; Ubiquitin ligase Q96IG2 84961 17q12 human S251-p 1875005604 RGCHKLQsLCASGCS protein degradation; molecular association, regulation carcinogenesis, inhibited; cell growth, inhibited; apoptosis, induced FBXO31(INDUCES) 34587475 1 0 0 +GLI2 GLI2 C2H2-type zinc finger protein; Oncoprotein; Transcription factor P10070 2736 2q14.2 human K757-ac 31077500 TPHTRNTkLPPLPGS protein degradation; ubiquitination; activity, inhibited transcription, inhibited 23762415; 31576013 2 0 0 +POLI POLI DNA repair, damage; EC 2.7.7.7; Transferase Q9UNA4 11201 18q21.2 human K551-ub 50771308 LSGKSREkFQGKGSV protein degradation 26370087 1 1 0 +FBXO5 FBX5 UBIQUITIN LIGASE; Ubiquitin conjugating system; Ubiquitin ligase Q9UKT4 26271 6q25.2 human Y142-p 15339200 ALETSRLyEDSGYSS protein stabilization 20717963 1 0 0 +ARHGEF2 ARHGEF2 GEF; GEF, Rac/Rho; Motility/polarity/chemotaxis Q92974 9181 1q22 human S186-p 1220712 NMRNRTLsVESLIDE molecular association, regulation; intracellular localization cytoskeletal reorganization TUBB2B(DISRUPTS) 21513698 1 1 1 inhibits microtubule binding and stabilization, acetylation, regulates cell polarization +GCK GK Carbohydrate Metabolism - amino sugar and nucleotide sugar; Carbohydrate Metabolism - galactose; Carbohydrate Metabolism - glycolysis and gluconeogenesis; Carbohydrate Metabolism - starch and sucrose; EC 2.7.1.2; Kinase, other; Mitochondrial P35557 2645 7p13 human S411-p 15426313 ITVGVDGsVYKLHPS Hexokinase_2 enzymatic activity, inhibited; protein conformation 21420961 0 1 1 +YWHAH 14-3-3 eta Adaptor/scaffold; Nuclear receptor co-regulator Q04917 7533 22q12.3 human S25-p 14159200 ERYDDMAsAMKAVTE 14-3-3 molecular association, regulation carcinogenesis, induced; cell motility, induced; cytoskeletal reorganization; transcription, inhibited; signaling pathway regulation Snail2(INDUCES) 33116123 1 4 0 after binding Snali2, induces Snail2 binding to CDH1 promoter, thus inducing cancer invasion through the KHK-A-YWHAH-SLUG-CDH1 pathway +XRCC5 Ku80 DNA-binding; EC 3.6.1.-; EC 3.6.4.-; Helicase; Nuclear receptor co-regulator; Nucleolus; RNA-binding P13010 7520 2q35 human K156-ub 15391472 IIIHSLKkCDISLQF Ku_N molecular association, regulation DNA repair, induced DNA(DISRUPTS) 27895153 1 1 11 +TP53 p53 Activator; DNA-binding; Motility/polarity/chemotaxis; Nuclear receptor co-regulator; Transcription factor; Tumor suppressor P04637 7157 17p13.1 human T18-p 447541 EPPLSQEtFSDLWKL P53_TAD protein degradation; protein stabilization; acetylation; molecular association, regulation; protein conformation cell cycle regulation; carcinogenesis, induced; apoptosis, altered; cell growth, induced; transcription, induced; transcription, altered S100B(INDUCES); S100A1(INDUCES); S100A4(INDUCES); CBP(INDUCES); MDM2(DISRUPTS); S100A6(INDUCES); p300(INDUCES); S100A2(INDUCES) DNA(INDUCES) 10734067; 11258706; 11875057; 12860987; 15542844; 18794113; 19819244; 20962272; 22112863; 25584963; 26742101; 33745968; 34168813 35 0 0 +Pebp1 RKIP Lipid-binding; Protein kinase, regulatory subunit P31044 29542 12q16 rat S153-p 448755 RGKFKVEsFRKKYHL PBP molecular association, regulation; enzymatic activity, inhibited; activity, inhibited; enzymatic activity, induced signaling pathway regulation RAF1(DISRUPTS) 12551925; 27568556; 35696587 9 16 1 regulates ?-AR signaling through inhibition of GRK2 activity,; BK-induced functional DOR competence in sensory neurons; RKIP inhibits MAP kinase activation in response to growth factors or PKC activators, and PKC can regulate Raf-1 signaling through phosphorylation of RKIP. Classical and atypical PKCs phosphorylate RKIP on Ser-153, which results in the displacement of RKIP from Raf-1, freeing Raf-1 to activate downstream targets.. ; enhances PKA activity +CD79A Ig-alpha Immunoglobulin superfamily; Membrane protein, integral P11912 973 19q13.2 human K225-ub 12113956 IGDVQLEkP______ intracellular localization 32127472 1 3 3 in cytoplasm +DLGAP5 DLG7 Cell cycle regulation; Microtubule-binding Q15398 9787 14q22.3 human S627-p 456345 VKLFSGLsVSSEGPS molecular association, regulation; intracellular localization KIF5B(INDUCES); KPNB1(INDUCES) 37484914 2 7 0 +UBE2K UBE2K EC 6.3.2.19; Ligase; UBIQUITIN LIGASE; Ubiquitin conjugating system; Ubiquitin ligase P61086 3093 4p14 human K14-sm 12004435 QRIKREFkEVLKSEE UQ_con molecular association, regulation; ubiquitination; protein conformation UBE1(DISRUPTS) 15723079 2 2 0 inhibits ubiquitination +RUNX1 AML1 iso8 DNA-binding; Oncoprotein; Transcription factor Q01196-8 861 21q22.12 human T300-p 454403 SPSVHPAtPISPGRA protein degradation cell differentiation, induced 16046550; 17015473; 22531928 6 1 8 +KAT7 MYST2 ACETYLTRANSFERASE; Acetyltransferase; EC 2.3.1.48; Nuclear receptor co-regulator; Transcription, coactivator/corepressor O95251 11143 17q21.33 human T97-p 3178404 KKYPLRQtRSSGSET protein stabilization; acetylation; ubiquitination cell growth, induced 33014433; 34535630 2 6 0 inhibits ubiquitination mediated degradation; induces H4 acetylation +Pde4b PDE4B EC 3.1.4.53; Nucleotide Metabolism - purine; Phosphodiesterase Q8VBU5 18578 4 C6|4 46.99 cM mouse S118-p 449097 GHSQRREsFLYRSDS enzymatic activity, induced 26192746 4 22 1 +MAPT Tau iso8 ACETYLTRANSFERASE; Acetyltransferase; Cytoskeletal P10636-8 4137 17q21.31 human S396-p 449081 GAEIVYKsPVVSGDT O-GlcNAc glycosylation; molecular association, regulation; protein processing; intracellular localization; protein conformation; phosphorylation cell differentiation, inhibited; apoptosis, induced; cell growth, inhibited; autophagy, inhibited; cytoskeletal reorganization TUBA1A(DISRUPTS); TUBA4A(DISRUPTS); Tau iso8(INDUCES); TUBB(DISRUPTS) 10818091; 11034902; 12414518; 14761950; 15190058; 15542598; 16687396; 18052981; 18725412; 19451179; 24312574; 33710538; 33895139; 33967735; 34220449; 34560101; 8318230 192 49 90 +RAP1GAP2 RAP1GAP2 GAP; GAP, Ras Q684P5 23108 17p13.3 human S7-p 455267 _MFGRKRsVSFGGFG molecular association, regulation cell adhesion, induced 14-3-3 zeta(DISRUPTS); 14-3-3 beta(DISRUPTS) 18039662 3 3 10 +BRD4 BRD4 KINASE; Kinase, protein; Protein kinase, Ser/Thr (non-receptor); Protein kinase, atypical O60885 23476 19p13.12 human S492-p 27806305 SSDSSSDsSSDSDSS molecular association, regulation BID(INDUCES) 23317504 1 0 0 +KCNMB4 KCNMB4 Channel, potassium; Membrane protein, integral; Membrane protein, multi-pass Q86W47 27345 12q15 human S210-p 451270 AMKKRKFs_______ activity, inhibited 11790768 1 0 0 regulates slowpoke K(+) channel kinetics +PIN4 PIN4 EC 5.2.1.8; Isomerase; Mitochondrial; Nucleolus Q9Y237 5303 Xq13.1 human Y122-p 456175 PVKTKFGyHIIMVEG Rotamase_3 cell growth, induced 29323298 1 18 150 mitochondrial respiration and tumour growth, expression of F3?T3 fusion induces peroxisome biogenesis through phosphorylation of PIN4 Y122 +CASP8 CASP8 Apoptosis; EC 3.4.22.61; Protease Q14790 841 2q33.1 human Y448-p 1032277 TILTEVNyEVSNKDD Peptidase_C14 enzymatic activity, inhibited apoptosis, altered 18086677 2 2 0 +PKD2L1 PKD2L1 Channel, cation; Membrane protein, integral; Membrane protein, multi-pass; Motility/polarity/chemotaxis Q9P0L9 9033 10q24.31 human C38-pa 59032203 PHGTLRVcTISSTGP activity, induced 27754867 1 0 0 channel activity regulated independently of phosphorylation +Elk1 ELK1 DNA-binding; Transcription factor A4GTP4 314436 Xq11 rat S159-p 2028400 YMRSGLYsTFTIQSL activity, inhibited transcription, inhibited SRF(DISRUPTS) 18088355 1 0 1 +Pikfyve PIKFYVE Carbohydrate Metabolism - inositol phosphate; EC 2.7.1.150; KINASE; Kinase, lipid; Motility/polarity/chemotaxis; Protein kinase, Ser/Thr (non-receptor) Q9Z1T6 18711 1|1 C2 mouse S307-p 457532 PARNRSAsITNLSLD intracellular localization 23905686 3 55 145 recruitment to vesicles to catalyse PtdIns(3,5)P2 production +Tp53 p53 Activator; DNA-binding; Motility/polarity/chemotaxis; Nuclear receptor co-regulator; Transcription factor; Tumor suppressor P02340 22059 11 B3|11 42.83 cM mouse S389-p 447535 VKKVGPDsD______ activity, induced cell cycle regulation; apoptosis, altered; apoptosis, induced; transcription, induced; transcription, altered; cell growth, altered DNA(INDUCES) 15361844; 15456863; 15867355; 18195040; 18606816; 8910602 118 15 0 induced by cyclin E oveerexpression in high density cells; in response to pX +IRAK1 IRAK1 EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, Ser/Thr (non-receptor); Protein kinase, TKL P51617 3654 Xq28 human T66-p 447722 CERSGQRtASVLWPW Death molecular association, regulation; protein conformation; phosphorylation transcription, altered; signaling pathway regulation TRAF6(DISRUPTS); IRAK1(INDUCES); ACP1(DISRUPTS) 12138165; 18524972 3 0 0 dimerization +Stxbp1 STXBP1 Vesicle O08599 20910 2 B|2 22.09 cM mouse T479-p 25698802 TYQLSRWtPIIKDIM Sec1 molecular association, regulation; protein processing neural plasticity; apoptosis, inhibited APBA1(INDUCES); STX1A(INDUCES) 22765017; 32081899 2 0 0 induced synaptic recovery; regulates APP processing and synaptic vesicle trafficking; cell viability increased +Rara RARA DNA-binding; Nuclear receptor; Oncoprotein; Transcription factor P11416 19401 11 D|11 62.76 cM mouse S77-p 455459 EIVPSPPsPPPLPRI activity, induced transcription, altered 9230306 11 2 0 +PFN1 profilin 1 Actin-binding; Cytoskeletal; Motility/polarity/chemotaxis P07737 5216 17p13.2 human S138-p 2850008 MASHLRRsQY_____ Profilin molecular association, regulation; intracellular localization; activity, inhibited cell cycle regulation; carcinogenesis, induced; cell growth, inhibited; cell motility, induced; cell growth, induced; apoptosis, inhibited ACTA1(DISRUPTS); Huntingtin(DISRUPTS); VASP(DISRUPTS) 18573880; 25084196; 25681442; 30814249 9 0 0 migration and invasion ; inhibits cell migration; inhibits anitumor activity of profilin-1 in the nucleus +NCOA1 SRC-1 ACETYLTRANSFERASE; Acetyltransferase; DNA-binding; EC 2.3.1.48; Nuclear receptor co-regulator; Oncoprotein; Transcription, coactivator/corepressor Q15788 8648 2p23.3 human S1185-p 449064 GTPPASTsPFSQLAA DUF1518 transcription, altered 11073973; 12163482 4 0 0 +Gabra2 GABRA2 Membrane protein, integral; Membrane protein, multi-pass; Transporter; Transporter, ion channel P26048 14395 5 C3.1|5 37.59 cM mouse S359-p 1869636101 DKKKEKGsVMIQNNA molecular association, regulation; intracellular localization neural plasticity ARHGEF9(DISRUPTS); gephyrin(DISRUPTS) 32620552 1 1 0 +ACLY ACLY Carbohydrate Metabolism - citrate (TCA) cycle; EC 2.3.3.8; Lyase; Transferase P53396 47 17q21.2 human K554-ac 4131806 EILIPVFkNMADAMR CoA_binding protein stabilization; molecular association, regulation; ubiquitination carcinogenesis, induced; cell growth, induced UBR4(INDUCES) 23932781; 31197036 2 5 1 inhibits ubiquitination, high glucose decreases interaction +Calm1 Calmodulin Calcium-binding; Protein phosphatase, regulatory subunit P0DP29 24242 6q32 rat Y139-p 448708 DGDGQVNyEEFVQMM EF-hand_7 activity, induced; protein stabilization 25830911 4 5 18 +Fmr1 FMR1 Nucleolus; RNA-binding; Translation Q80WE1 24948 Xq37 rat S478-p 469583 NSEASNAsETESDHR FXMRP1_C_core translation, inhibited 22539853 21 6 0 Phosphorylated FMR1 suppresses translation of Arc; Dephosphorylation by PPP2CA is necessary for mGluR-triggered dendritic Arc expression. +PML PML Nucleolus; Oncoprotein; SUMO LIGASE; SUMO conjugating system; SUMO ligase; Transcription factor; Tumor suppressor; Ubiquitin conjugating system P29590 5371 15q24.1 human S8-p 470923 MEPAPARsPRPQQDP sumoylation apoptosis, altered 19015637 1 32 1 induces sumoylation +ANLN anillin iso2 Actin-binding; Motility/polarity/chemotaxis Q9NQW6-2 54443 7p14.2 human Y634-p 450421 SEDRDLLySIDAYRS intracellular localization cell cycle regulation 28081137 1 7 38 anillin recruitment to the equatorial cortex at anaphase +Xbp1 XBP1 iso2 DNA-binding; Transcription factor O35426-2 22433 mouse K257-ac 1879877100 RFDHVYTkPLVLEIP protein degradation apoptosis, induced 31541078 1 1 0 K257 and 297 mediates hepatic steatosis, apoptosis, and insulin resistance +Ahcyl1 AHCYL1 Amino Acid Metabolism - cysteine and methionine; EC 3.3.1.1; Hydrolase; Other Amino Acids Metabolism - selenoamino acid Q80SW1 229709 3 F2.3|3 46.83 cM mouse T82-p 456617 YSSAASYtDSSDDEV molecular association, regulation PIP5K1A(INDUCES) 26509711 1 3 3 +DYRK2 DYRK2 iso2 EC 2.7.12.1; KINASE; Kinase, protein; Protein kinase, CMGC; Protein kinase, dual-specificity (non-receptor) Q92630-2 8445 12q15 human S483-p 1874397810 SVKRITEsTGAITSI cell cycle regulation; apoptosis, induced 34363019 1 1 0 +HK2 HK2 Carbohydrate Metabolism - amino sugar and nucleotide sugar; Carbohydrate Metabolism - fructose and mannose; Carbohydrate Metabolism - galactose; Carbohydrate Metabolism - glycolysis and gluconeogenesis; Carbohydrate Metabolism - starch and sucrose; EC 2.7.1.1; Kinase, other; Mitochondrial P52789 3099 2p12 human K315-sm 1881215706 LILVKMAkEELLFGG carcinogenesis, inhibited; cell growth, inhibited 33753739 1 0 0 SUMO-defective HK2 contributes to prostate cancer cell proliferation and tumorigenesis +Cd22 CD22 Cell surface; Membrane protein, integral P35329 12483 7 B1|7 19.26 cM mouse Y843-p 456699 PEDESIHySELVQFG molecular association, regulation; activity, inhibited; phosphorylation SHP-1(INDUCES) 11551923; 18024433; 27276708 6 0 5 negatively regulate calcium signal +UBE2I UBC9 EC 6.3.2.-; EC 6.3.2.19; Ligase; Nuclear receptor co-regulator; SUMO LIGASE; SUMO conjugating system; SUMO ligase; UBIQUITIN LIGASE; Ubiquitin conjugating system; Ubiquitin ligase P63279 7329 16p13.3 human K154-sm 60338001 RVRAQAKkFAPS___ signaling pathway regulation 27501389 1 1 0 TTR specifically modulates general protein SUMOylation +KCNC4 Kv3.4 Channel, potassium; Membrane protein, integral; Membrane protein, multi-pass Q03721 3749 1p13.3 human S21-p 451078 KSGNKPPsKTCLKEE Potassium_chann receptor inactivation, altered; protein conformation; activity, inhibited 7993631; 9649584 2 1 0 +BSG BSG iso2 Immunoglobulin superfamily; Membrane protein, integral P35613-2 682 19p13.3 human Y140-p 1868502601 PVTDWAWyKITDSED Ig_3 molecular association, regulation carcinogenesis, induced; cell motility, induced MGAT5(INDUCES) 32291412 1 1 0 induce MMP-9 expression +PIAS4 PIAS4 EC 6.3.2.-; Nuclear receptor co-regulator; SUMO LIGASE; SUMO conjugating system; SUMO ligase; Transcription, coactivator/corepressor Q8N2W9 51588 19p13.3 human S18-p 56589715 MVMSFRVsDLQMLLG protein degradation; molecular association, regulation AREL1 iso2(INDUCES) 27162139 1 0 0 +SOX9 SOX9 DNA-binding; Transcription factor P48436 6662 17q24.3 human T236-p 40722389 GQSQGPPtPPTTPKT protein degradation; molecular association, regulation; ubiquitination apoptosis, induced; transcription, altered FBXW7(INDUCES) 27566146; 27625374 2 3 0 +FUNDC1 FUNDC1 Membrane protein, multi-pass; Mitochondrial Q8IVP5 139341 Xp11.3 human K119-ub 15388938 QIKKRANkAAPEINN FUN14 protein degradation autophagy, inhibited 28104734 1 2 11 +Npy1r NPY1R GPCR, family 1; Membrane protein, integral; Membrane protein, multi-pass; Receptor, GPCR P21555 29358 16p14 rat S362-p 2815303 HTDVSKTsLKQASPV receptor internalization, altered 15576634 1 0 0 may be an artifact of the truncation mutants +RHEB RHEB G protein; G protein, monomeric; G protein, monomeric, Rheb Q15382 6009 7q36.1 human S130-p 18157800 LHMERVIsYEEGKAL Ras activity, inhibited; phosphorylation Other(DISRUPTS) 21336308 1 1 0 reduce mTORC1 activity(S6K1 phosphorylation), disrupted Guanine nucleotide binding activity +EPHB3 EphB3 EC 2.7.10.1; KINASE; Kinase, protein; Membrane protein, integral; Protein kinase, TK; Protein kinase, tyrosine (receptor) P54753 2049 3q27.1 human Y614-p 448275 VYIDPFTyEDPNEAV EphA2_TM molecular association, regulation RASA1(INDUCES); Fyn(INDUCES); CRK(INDUCES) 9674711 1 25 200 +PIN1 PIN1 EC 5.2.1.8; Isomerase; Nuclear receptor co-regulator Q13526 5300 19p13.2 human S138-p 25519816 QKPFEDAsFALRTGE Rotamase intracellular localization cell cycle regulation; transcription, induced 22566623; 34052323 3 2 0 +XPC XPC DNA repair, damage Q01831 7508 3p25.1 human S94-p 3194024 VIKDEALsDGDDLRD ubiquitination DNA repair, induced 29660033 1 45 2 UVB-induced DNA damage repair; recruitment of NER factors to the chromatin post-UVB irradiation +Star STAR Carrier; Lipid-binding; Mitochondrial P51557 20845 8 A2|8 14.17 cM mouse S232-p 2089100 VLHPLAGsPSKTKLT START activity, induced; intracellular localization; enzymatic activity, induced 19007846; 24945345 3 0 0 retention of StAR at OMM, mitochondrial association, regulation of cholesterol transport; promotes progesterone production +Src Src iso1 EC 2.7.10.2; KINASE; Kinase, protein; Oncoprotein; Protein kinase, TK; Protein kinase, tyrosine (non-receptor) P05480-1 20779 2 H1|2 78.35 cM mouse Y527-p 7445100 LQAFLEDyFTSTEPQ enzymatic activity, inhibited 30622194 8 0 0 +Bcar1 P130Cas Adaptor/scaffold; Motility/polarity/chemotaxis Q61140 12927 8|8 E1 mouse Y271-p 451537 NQYGQEVyDTPPMAV carcinogenesis, induced; cell motility, induced 21963850 3 21 285 migration, invasion, metastasis +CDC25B CDC25B iso2 EC 3.1.3.48; Motility/polarity/chemotaxis; Nuclear receptor co-regulator; PHOSPHATASE; Protein phosphatase, dual-specificity P30305-2 994 20p13 human S146-p 465509 PVRLLGHsPVLRNIT M-inducer_phosp intracellular localization cell cycle regulation 12107172 1 8 10 +Nphs1 NPHS1 Cell adhesion; Immunoglobulin superfamily; Membrane protein, integral Q9QZS7 54631 7|7 B1 mouse Y1191-p 2299202 MAFPGHLyDEVERVY molecular association, regulation cytoskeletal reorganization NCK1(INDUCES) 18212058; 34391780 8 0 0 induce podocyte repair +ZC3HC1 NIPA Cell cycle regulation; Ubiquitin conjugating system Q86WB0 51530 7q32.2 human S359-p 483339 TRSWDSSsPVDRPEP molecular association, regulation cell cycle regulation SKP1A(DISRUPTS) 17389604 2 24 11 +RRN3 TIF1A Nucleolus; Transcription initiation complex Q9NYV6 54700 16p13.11 human S649-p 448839 PVLYMQPsPL_____ activity, induced; molecular association, regulation cell cycle regulation; cell growth, induced; transcription, induced POLR2F(INDUCES); POLR1B(INDUCES) 12620228; 15558034; 18498750; 21098478 4 5 1 +DCLRE1C Artemis DNA repair, damage; Deoxyribonuclease; EC 3.1.-.- Q96SD1 64421 10p13 human T656-p 38410200 SDFEVPStPEAELPK molecular association, regulation; intracellular localization DNA repair, induced PAXIP1(INDUCES) 25512557 1 1 0 Artemis prevents end resection and promotes non-homologous end joining +Hsp90aa1 HSP90A Chaperone; Heat shock protein P07901 15519 12 F1|12 60.75 cM mouse K295-ac 486377 QEELNKTkPIWTRNP HSP90 molecular association, regulation; intracellular localization FKBP5(INDUCES); FKBP4(DISRUPTS) 25442004 4 3 0 inhibits GR nuclear translocation +TRPV5 TRPV5 Channel, cation; Membrane protein, integral; Membrane protein, multi-pass; Motility/polarity/chemotaxis Q9NQA5 56302 7q34 human T708-p 4710939 WEILRQNtLGHLNLG activity, induced; molecular association, regulation Calmodulin(DISRUPTS) 21576356; 24828496 3 1 0 channel activation, Ca2+ uptake +STK11 LKB1 Autophagy; EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, CAMK; Protein kinase, Ser/Thr (non-receptor); Tumor suppressor Q15831 6794 19p13.3 human S334-p 448146 DTKDRWRsMTVVPYL carcinogenesis, induced; cell growth, inhibited 34193159 3 0 0 +Vps35 VPS35 Vesicle Q9EQH3 65114 8 C3|8 41.61 cM mouse S7-p 486029 _MPTTQQsPQDEQEK molecular association, regulation signaling pathway regulation Other(DISRUPTS) 24240093 1 18 1 Mutation of S7 to alanine inhibited the insulin-stimulated dissociation of VPS35 from low-density microsomal membranes, and inhibited the insulin-stimulated decrease in GLUT4 expression +ADRB2 ADRB2 GPCR, family 1; Membrane protein, integral; Membrane protein, multi-pass; Receptor, GPCR P07550 154 5q32 human T360-p 5403100 GYSSNGNtGEQSGYH molecular association, regulation; receptor internalization, altered ARRB2(INDUCES) 18801735 3 0 0 PD-N mutant (residues 355-364) failed to recruit ARRB2 to the plasma membrane +NR3C1 GR DNA-binding; Mitochondrial; Nuclear receptor; Transcription factor P04150 2908 5q31.3 human S134-p 3178932 ANLNRSTsVPENPKS GCR molecular association, regulation; intracellular localization transcription, induced; transcription, inhibited; transcription, altered PELP1(INDUCES); 14-3-3 zeta(INDUCES) DNA(DISRUPTS) 21930780; 24291004; 26825173 12 11 6 recruitment of ligand-bound GR to the Brk promoter; inhibits interaction with IGFBP1 promoter; impairs dexamethasone-induced glucocorticoid receptor nuclear translocation +FOXM1 FOXM1 iso2 DNA-binding; Transcription factor Q08050-2 2305 12p13.33 human S724-p 18009877 SKILLDIsFPGLDED sumoylation; intracellular localization cell cycle regulation; transcription, induced 25533473 3 1 0 inhibits FOXM1iso2 sumoylation, induces nuclear localization +Btk Btk EC 2.7.10.2; KINASE; Kinase, protein; Protein kinase, TK; Protein kinase, tyrosine (non-receptor) P35991 12229 X E3|X 56.18 cM mouse Y551-p 447486 RYVLDDEyTSSVGSK PK_Tyr_Ser-Thr enzymatic activity, induced cell growth, altered GTF2I(NOT_REPORTED) 7565679; 9012831; 9391111 34 14 136 PI 3-kinase is required for BTK activation and transformation. +H2BC3 H2B DNA-binding P33778 3018 6p22.2 human S14-p 449904 APAPKKGsKKAITKA Histone intracellular localization cell cycle regulation 28740074 10 1 0 cytokinesis, HIPK2/H2B activities at the midbod +FZR1 FZR1 UBIQUITIN LIGASE; Ubiquitin conjugating system Q9UM11 51343 19p13.3 human S163-p 4661904 KSQKLLRsPRKPTRK protein stabilization; molecular association, regulation; activity, inhibited apoptosis, induced APC1(DISRUPTS); CDC23(DISRUPTS) 18818692; 26083744; 30498084 3 0 0 inhibits cyclin B1 degradation; AURKA stabilization +RGS2 RGS2 GAP; GAP, RGS P41220 5997 1q31.2 human S3-p 1870773103 _____MQsAMFLAVQ protein stabilization; molecular association, regulation FBXO44(DISRUPTS) 33008920 1 0 0 +PRKAA2 AMPKA2 Autophagy; EC 2.7.11.1; EC 2.7.11.27; EC 2.7.11.31; KINASE; Kinase, protein; Protein kinase, CAMK; Protein kinase, Ser/Thr (non-receptor) P54646 5563 1p32.2 human Y179-p 11150878 TSCGSPNyAAPEVIS Pkinase enzymatic activity, inhibited; phosphorylation apoptosis, induced; autophagy, inhibited; signaling pathway regulation 34673141 1 1 2 inhibits phosphorylation at T172, regulates ULK1 signaling +CAMKK1 CAMKK1 EC 2.7.11.17; KINASE; Kinase, protein; Protein kinase, Other; Protein kinase, Ser/Thr (non-receptor) Q8N5S9 84254 17p13.2 human S475-p 486103 RREERSMsAPGNLLV molecular association, regulation; enzymatic activity, inhibited 14-3-3 eta(INDUCES) 18242179 2 14 7 14-3-3 inhibits CAMKK1 activity. +PHLPP1 PHLPP EC 3.1.3.16; PHOSPHATASE; Protein phosphatase, Ser/Thr (non-receptor); Tumor suppressor O60346 23239 18q21.33 human S345-p 1871700801 RAPRPVVsDTESFSL cell cycle regulation 33397691 1 1 0 +MAVS MAVS Adaptor/scaffold; Membrane protein, integral Q7Z434 57506 20p13 human K500-ub 7761223 PRPQADRkFQEREVP protein degradation; molecular association, regulation transcription, inhibited; signaling pathway regulation IKKE(INDUCES) 19380491; 26246171 3 0 0 regulates IFN signaling ; inhibits RLR-mediated antiviral signaling +WBP2 WBP2 Cell development/differentiation; Nuclear receptor co-regulator Q969T9 23558 17q25.1 human Y192-p 20612405 MMDGAMGyVQPPPPP molecular association, regulation; intracellular localization carcinogenesis, induced; cell growth, induced; transcription, induced ER-alpha(INDUCES) 21642474 1 0 1 epithelial-mesenchymal transition induced +FXYD1 PLM Cell surface; Channel, misc.; Membrane protein, integral P56513 476487 dog S83-p 451424 EEGTFRSsIRRLSTR activity, induced 17991751 22 20 60 increases Na(+) affinity of ATP1A1/B1 +SMAD1 SMAD1 DNA-binding; Transcription factor Q15797 4086 4q31.21 human S465-p 448363 HNPISSVs_______ activity, induced; molecular association, regulation; intracellular localization transcription, altered SMAD4(INDUCES) 9136927; 9335504 12 20 59 +NEDD4 NEDD4 iso4 EC 6.3.2.-; EC 6.3.2.19; Ligase; Nuclear receptor co-regulator; UBIQUITIN LIGASE; Ubiquitin conjugating system; Ubiquitin ligase P46934-4 4734 15q21.3 human Y43-p 458526 ILGASDPyVRVTLYD C2 protein conformation; enzymatic activity, induced endocytosis, induced; cell growth, induced; signaling pathway regulation 25292214 1 1 1 +HSPA5 GRP78 Chaperone; Heat shock protein; KINASE P11021 3309 9q33.3 human K152-ac 13362603 ISAMVLTkMKETAEA HSP70 molecular association, regulation; phosphorylation apoptosis, induced; signaling pathway regulation PERK(DISRUPTS) 20371724 1 1 0 induces phosphorylation of elf2a and activation of eIf2a-ATF4-CHOP pathway +Blnk BLNK Adaptor/scaffold Q9QUN3 17060 19 C3|19 34.26 cM mouse T152-p 23303201 AKARLAStLPAPNSL molecular association, regulation; ubiquitination 14-3-3 beta(INDUCES) 22334673 2 0 0 Thr-152 phosphorylation induces BLNK ubiquitination at K37, K38, K42. +NFE2L2 NRF2 DNA-binding; Transcription factor Q16236 4780 2q31.2 human K487-ac 7106323 DFNEMMSkEQFNEAQ bZIP_Maf molecular association, regulation transcription, induced DNA(INDUCES) 19273602 1 1 0 +Sh2b3 LNK Adaptor/scaffold O09039 16923 5 F|5 61.99 cM mouse Y536-p 476934 LRAIDNQyTPLSQLC activity, induced; molecular association, regulation cell motility, altered; cell growth, altered LNK(INDUCES) 18753636 2 4 10 +FOSL2 FRA2 DNA-binding; Transcription factor P15408 2355 2p23.2 human T322-p 14573760 SDSLNSPtLLAL___ methylation cell differentiation, induced; transcription, induced 25547114 2 5 0 +Notch1 Notch 1 Membrane protein, integral; Motility/polarity/chemotaxis; Oncoprotein; Receptor, misc.; Transcription factor Q01705 18128 2 A3|2 18.91 cM mouse K1764-ac 18899501 LWFPEGFkVSEASKK protein stabilization; ubiquitination 21499261 1 1 0 +Drd2 DRD2 GPCR, family 1; Membrane protein, integral; Membrane protein, multi-pass; Receptor, GPCR P61169 24318 8q23 rat K241-ub 4793400 ANLKTPLkGNCTHPE 7tm_1 protein degradation; intracellular localization 18946766 2 0 0 +NUPR1 NUPR1 Apoptosis; Cell cycle regulation; Cell development/differentiation O60356 26471 16p11.2 human K76-ac 465463 KLQNSERkKRGARR_ Phospho_p8 intracellular localization 16294328 1 0 0 regulates nuclear transport +Myocd myocardin Cell development/differentiation; Transcription factor Q8VIM5 214384 11|11 B3 mouse S454-p 3627508 TGFYHFGsTSSSPPI transcription, inhibited 16141410 1 0 0 +Pias1 PIAS1 EC 6.3.2.-; Nuclear receptor co-regulator; SUMO LIGASE; SUMO conjugating system; SUMO ligase; Transcription, coactivator/corepressor A9UK05 300772 8q24 rat S503-p 3177703 LSLPHQAsPVSRTPS enzymatic activity, induced transcription, inhibited 30849179 1 51 11 GADD45A expression +Map3k2 MEKK2 EC 2.7.11.25; KINASE; Kinase, protein; Protein kinase, STE; Protein kinase, Ser/Thr (non-receptor) Q61083 26405 18|18 B1 mouse T283-p 28761201 EYNDGRKtFPRARRT molecular association, regulation; enzymatic activity, inhibited; protein conformation cell growth, induced; transcription, inhibited 14-3-3 epsilon(INDUCES) 23963453 1 2 3 dimerization, transcription of GAL4-c-Jun was increased in T283A mutant +Pkd2 PKD2 Channel, cation; Membrane protein, integral; Membrane protein, multi-pass O35245 18764 5 E5|5 50.68 cM mouse T719-p 25690300 KLKLKRNtVDAISES activity, inhibited 22518003 1 0 0 Negative regulation of flow-induced Ca2+ entry +Cidec CIDEC Apoptosis P56198 14311 6|6 E3 mouse K226-ub 12718507 EEQPAKAkPSSLLPA protein degradation 20089860 1 0 0 +SRSF1 SF2 RNA splicing; RNA-binding; Spliceosome Q07955 6426 17q22 human S207-p 2303910 PSYGRSRsRSRSRSR protein conformation 24449914 2 0 1 RS domain adopts an extended conformation +CALM1 Calmodulin Calcium-binding; Protein phosphatase, regulatory subunit P0DP23 801 14q32.11 human T80-p 448704 MARKMKDtDSEEEIR activity, induced signaling pathway regulation 25108821; 36273583 11 6 0 induces CaV1.2 activity; CaM phosphorylation promotes greater SK channel inhibition through hMR1 mediated PIP2 hydrolysis. +Mitf MITF iso8 DNA-binding; Oncoprotein; Transcription factor Q08874-8 17342 6 D3|6 45.05 cM mouse S307-p 451221 IPSTGLCsPDLVNRI DUF3371 activity, induced; molecular association, regulation transcription, induced SMARCA4(INDUCES); hnRNP P2(INDUCES) 11792706; 24257758 2 22 5 +CRK CRK Adaptor/scaffold; Motility/polarity/chemotaxis; Oncoprotein P46108 1398 17p13.3 human Y239-p 450357 NLQNGPIyARVIQKR SH3_2 molecular association, regulation CSK(INDUCES) 25381819 2 5 268 +Abcc9 ABCC9 Channel, potassium; Membrane protein, integral; Membrane protein, multi-pass; Transporter; Transporter, ABC family Q63563 25560 4q44 rat T632-p 483974 FESCKKHtGVQSKPI activity, induced; protein stabilization; protein conformation 26198630 3 1 0 +GEM GEM G protein; G protein, monomeric; G protein, monomeric, RGK P55040 2669 8q22.1 human S289-p 450648 AFKLKSKsCHDLSVL protein stabilization; molecular association, regulation cytoskeletal reorganization 14-3-3 beta(INDUCES); KPNA5(DISRUPTS) 14701738; 17605761 2 17 0 interaction abolished in triple phosphomimetic mutant S261/287/289D; Cell flattening and neurite extension; Mutation of either S23 or S289 inhibits binding to 14-3-3 +Vav1 VAV1 GEF; GEF, Rac/Rho; Motility/polarity/chemotaxis; Oncoprotein P27870 22324 17 D|17 29.76 cM mouse Y160-p 447865 AEEDEDLyDCVENEE molecular association, regulation; protein conformation; activity, inhibited; phosphorylation cytoskeletal reorganization; transcription, altered; cell growth, altered VAV1(INDUCES) 10669745; 20141838 9 2 0 +Ptk2 FAK iso2 EC 2.7.10.2; KINASE; Kinase, protein; Protein kinase, TK; Protein kinase, tyrosine (non-receptor) P34152-2 14083 15 D3|15 33.94 cM mouse Y428-p 447887 SGDETDDyAEIIDEE activity, induced; molecular association, regulation; enzymatic activity, induced carcinogenesis, induced; cell motility, induced; cell adhesion, induced; signaling pathway regulation; transcription, altered; cell growth, induced; cell motility, altered; cell adhesion, altered; cytoskeletal reorganization PLCG1(INDUCES); Src iso1(INDUCES) 10430888; 15252114; 17438336; 18031698; 19297531; 19553453; 20442405; 20493699; 21900245; 22138575; 22388104; 28759036 371 31 474 +PML PML iso4 Nucleolus; Oncoprotein; SUMO LIGASE; SUMO conjugating system; SUMO ligase; Transcription factor; Tumor suppressor; Ubiquitin conjugating system P29590-4 5371 15q24.1 human S527-p 451472 PHLDGPPsPRSPVIG DUF3583 protein stabilization apoptosis, altered 15093545 2 46 23 Phosphorylation of PML is associated with enhanced sumoylation and apoptosis induced by As2O3. +Grm7 mGluR7 GPCR, family 3; Membrane protein, integral; Membrane protein, multi-pass; Receptor, GPCR Q68ED2 108073 6|6 E3 mouse S862-p 2846504 NVQKRKRsFKAVVTA molecular association, regulation; receptor internalization, altered PICK1(INDUCES); Calmodulin(DISRUPTS) 18549785 4 0 0 +SASH1 SASH1 Tumor suppressor O94885 23328 6q24.3-q25.1 human S90-p 460917 ELRKRRVsQDLEVEK molecular association, regulation 14-3-3 beta(INDUCES) 19648646 1 44 13 yeast 14-3-3 used for binding assay +Casp2 CASP2 Apoptosis; EC 3.4.22.55; Protease P29594 12366 6 B2.1|6 20.54 cM mouse S384-p 1869992407 MRNTKRGsWYIEALT Peptidase_C14 enzymatic activity, inhibited cell cycle regulation; apoptosis, inhibited 32811973 1 1 0 +Nefm NFM Cytoskeletal P08553 18040 14|14 D1 mouse S537-p 448043 EEDEGVKsDQAEEGG cytoskeletal reorganization 19193875 3 6 0 slightly altered axoplasmic organization in 7S/A mice mutant +CLDN16 Claudin-16 Cell adhesion; Membrane protein, integral; Membrane protein, multi-pass Q9Y5I7 10686 3q28 human T233-p 11555106 AKMYAVDtRV_____ molecular association, regulation; intracellular localization ZO1(DISRUPTS); TRPV5(INDUCES) 31488724 2 0 0 Induce Ca2+permeation; increased the Trpv5 channel conductance and cell surface abundance levels +Ahcyl2 AHCYL2 Amino Acid Metabolism - cysteine and methionine; EC 3.3.1.1; Hydrolase; Motility/polarity/chemotaxis; Other Amino Acids Metabolism - selenoamino acid Q68FL4 74340 6|6 A3.3 mouse S157-p 7172002 ISQSSTDsYSSAASY molecular association, regulation SLC4A4(INDUCES) 27382360 2 0 0 S149 and T172 are also involved in activation of SLCA4 +JUNB JunB Motility/polarity/chemotaxis; Oncoprotein; Transcription factor P17275 3726 19p13.13 human Y182-p 41655504 GPEPPPVyTNLSSYS Jun transcription, induced 26217035 1 1 0 p21 promoter activity upon Adriamycin stimulation +Eif4g1 eIF4G RNA-binding; Translation; Translation initiation D3ZU13 287986 11q23 rat S1147-p 449800 VVQRSSLsRERGEKA activity, induced; molecular association, regulation ELF4(INDUCES); EIF4E(INDUCES) 16263769; 35163752 17 33 1 +CDH1 CDH1 Cell adhesion; Membrane protein, integral; Motility/polarity/chemotaxis; UBIQUITIN LIGASE; Ubiquitin ligase P12830 999 16q22.1 human Y797-p 6158370 TLMSVPRyLPRPANP protein degradation; ubiquitination carcinogenesis, induced 31286874 1 4 46 induces EMT phenotype +PXN PXN Adaptor/scaffold; Cell adhesion; Cytoskeletal; Motility/polarity/chemotaxis P49024 395832 chicken T403-p 448766 VVTALDRtWHPEHFF LIM intracellular localization cell adhesion, altered 9658172 1 1 0 +DTD1 DTD1 DNA replication; EC 3.1.-.-; Hydrolase Q8TEA8 92675 20p11.23 human T187-p 36396302 ESSKERNtPRKEDRS molecular association, regulation cell cycle regulation; cell growth, induced MCM7(INDUCES); MCM3(DISRUPTS) 25258324 1 0 8 decreases DTD1 incorporation into HMW, supports DNA replication initiation +Camk2b CAMK2B EC 2.7.11.17; KINASE; Kinase, protein; Protein kinase, CAMK; Protein kinase, Ser/Thr (non-receptor) P08413 24245 14q21 rat T334-p 48915802 STAASGTtMGLVEQA molecular association, regulation 26291163 1 1 0 inhibits interaction with F-actin, regulates synaptic plasticity +Ldha LDH-A Amino Acid Metabolism - cysteine and methionine; Apoptosis; Carbohydrate Metabolism - glycolysis and gluconeogenesis; Carbohydrate Metabolism - propanoate; Carbohydrate Metabolism - pyruvate; EC 1.1.1.27; Oxidoreductase P06151 16828 7 B3|7 30.6 cM mouse S196-p 1881982200 VLGEHGDsSVPVWSG enzymatic activity, induced 37267363 1 1 0 inhibits p62 degradation +SERINC5 SERINC5 Membrane protein, integral; Membrane protein, multi-pass Q86VE9 256987 5q14.1 human S360-p 1874340202 ARCCFCFsPGGEDTE Serinc protein degradation; molecular association, regulation endocytosis, induced 34380030 1 1 0 induces interaction with HIV-1 Nef protein +Srebf1 SREBP-1 iso1 DNA-binding; Membrane protein, integral; Membrane protein, multi-pass; Transcription factor P56720-1 78968 10q22 rat S418-p 1869370300 SLGSRGSsSGGSDSE protein stabilization; molecular association, regulation; intracellular localization transcription, induced SCAP(INDUCES) 31541353 1 0 0 activates genes involved in de novo lipogenesis +HTR1A 5-HT(1A) GPCR, family 1; Membrane protein, integral; Membrane protein, multi-pass; Receptor, GPCR P08908 3350 5q12.3 human T314-p 1867735500 LPSEAGPtPCAPASF 7tm_1 protein degradation; intracellular localization signaling pathway regulation 30712943 1 0 0 5-HT signaling +MAPKAP1 Sin1 Adaptor/scaffold Q9BPZ7 79109 9q33.3 human S260-p 28758701 PIHKFGFsTLALVEK CRIM protein stabilization cell growth, induced 23928304 1 0 0 high abundance of mTORC2 +CDCA2 CDCA2 Q69YH5 157313 8p21.2 human T412-p 3202359 DESLPANtPLRKGGT PP1_bind molecular association, regulation; intracellular localization; phosphorylation cell cycle regulation; chromatin organization, altered PPP1CC(DISRUPTS); NUP153(DISRUPTS); KPNB1(DISRUPTS) 21820363 1 8 0 +Fosb FosB DNA-binding; Transcription factor P13346 14282 7 A3|7 9.56 cM mouse T149-p 35530404 PRRPREEtLTPEEEE transcription, induced 25143625 1 1 0 +SP7 osterix C2H2-type zinc finger protein; DNA-binding; Transcription factor Q8TDD2 121340 12q13.13 human K312-ac 56714901 YGKASHLkAHLRWHT zf-C2H2 protein stabilization; molecular association, regulation cell differentiation, induced; transcription, induced DNA(INDUCES) 27250035 1 0 0 +NFKBIB IkB-beta Inhibitor Q15653 4793 19q13.2 human S313-p 452013 EKSGPCSsSSDSDSG activity, induced; intracellular localization transcription, inhibited; transcription, altered CCDC32(INDUCES) 12732617; 8887627; 9278383 4 0 0 Phosphorylation blocks NF-kB-directed transcription.; and in vivo, NFkB/Rel activation +TP53 p53 Activator; DNA-binding; Motility/polarity/chemotaxis; Nuclear receptor co-regulator; Transcription factor; Tumor suppressor P04637 7157 17p13.1 human K319-ub 11489913 TSSSPQPkKKPLDGE P53_tetramer protein degradation; molecular association, regulation; intracellular localization KPNA4(DISRUPTS) 19927155 2 2 0 +ITGB1BP1 ICAP1 Cell adhesion; Motility/polarity/chemotaxis O14713 9270 2p25.1 human S25-p 14574783 EISTKSKsVDSSLGG ICAP-1_inte_bdg intracellular localization 32005669 1 8 0 regulates localization of itself and of KRIT1 +ETS1 Ets-1 DNA-binding; Motility/polarity/chemotaxis; Oncoprotein; Transcription factor P14921 2113 11q24.3 human S285-p 449318 QRVPSYDsFDSEDYP Ets1_N_flank molecular association, regulation; activity, inhibited transcription, inhibited DNA(DISRUPTS) 12475968; 25024220 6 10 56 induces autoinhibition +NACA NACA iso1 Motility/polarity/chemotaxis; Transcription, coactivator/corepressor Q13765 4666 12q13.3 human T89-p 18012689 KLGLRQVtGVTRVTI NAC intracellular localization; activity, inhibited cell differentiation, inhibited; transcription, inhibited 30948508 1 2 1 +F2R PAR1 Cell development/differentiation; GPCR, family 1; Membrane protein, integral; Membrane protein, multi-pass; Receptor, GPCR P25116 2149 5q13.3 human S400-p 3627504 DPSSYNSsGQLMASK receptor desensitization, altered 10413505 1 1 0 receptor shutoff (not internalization) +CAMKK1 CAMKK1 EC 2.7.11.17; KINASE; Kinase, protein; Protein kinase, Other; Protein kinase, Ser/Thr (non-receptor) Q8N5S9 84254 17p13.2 human S458-p 486077 KSMLRKRsFGNPFEP enzymatic activity, inhibited 11574071 5 25 21 activity toward PKIV peptide +Gch1 GCH1 Cofactor and Vitamin Metabolism - folate biosynthesis; EC 3.5.4.16; Hydrolase P22288 29244 15p14 rat S51-p 469750 WKAGRPRsEEDNELN enzymatic activity, induced 21163945 3 15 1 possibly in vivo as in vitro closely resembled wild-type +STK4 MST1 Autophagy; EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, STE; Protein kinase, Ser/Thr (non-receptor) Q13043 6789 20q13.12 human T353-p 64227000 TMTDGANtMIEHDDT molecular association, regulation MOB1A(INDUCES); MST1(DISRUPTS) 28373297; 28373298 2 2 0 fluorescence polarization +Dusp8 DUSP8 EC 3.1.3.16; EC 3.1.3.48; Motility/polarity/chemotaxis; PHOSPHATASE; Protein phosphatase, dual-specificity O09112 18218 7 F5|7 87.59 cM mouse T518-p 22598802 PPLDSPGtPSPDGPW enzymatic activity, inhibited signaling pathway regulation 22100391 1 1 0 activates JNK pathway +RANBP1 RANBP1 Cell cycle regulation; G protein regulator, misc.; Microtubule-binding P43487 5902 22q11.21 human S60-p 456058 AKLFRFAsENDLPEW Ran_BP1 intracellular localization carcinogenesis, induced; cell growth, induced; apoptosis, inhibited 30747223 1 56 172 +PYGL PYGL Carbohydrate Metabolism - starch and sucrose; EC 2.4.1.1; Transferase P06737 5836 14q22.1 human S430-gl 1876695600 VDRLRRMsLIEEEGS Phosphorylase phosphorylation; enzymatic activity, induced 34939084 1 1 0 Ser-430 O-GlcNAcylation promotes S15 phosphorylation +Lcp2 SLP76 Adaptor/scaffold Q60787 16822 11|11 A4 mouse Y145-p 448220 LVDDAADyEPPPSNN molecular association, regulation; phosphorylation cell differentiation, altered; apoptosis, altered; cytoskeletal reorganization; cell adhesion, altered; transcription, induced; transcription, altered Btk(INDUCES) 11313406; 12640123; 16456002; 18342008; 18663126 21 1 0 mutation of this site impairs thrombus formation +PXN PXN Adaptor/scaffold; Cell adhesion; Cytoskeletal; Motility/polarity/chemotaxis P49023 5829 12q24.23 human Y31-p 448785 FLSEETPySYPTGNH molecular association, regulation; intracellular localization; phosphorylation carcinogenesis, induced; cell motility, induced; cell growth, induced; cytoskeletal reorganization ERK2(INDUCES); ERK1(INDUCES); DRP1(INDUCES) 26697169; 34475475; 35297710 49 8 64 +H3-3A H3F3A DNA-binding P84243 3020 1q42.12 human S10-p 18545301 TKQTARKsTGGKAPR Histone phosphorylation cell cycle regulation 14583461; 16185088 12 4 0 +Mapk14 P38A EC 2.7.11.24; KINASE; Kinase, protein; Protein kinase, CMGC; Protein kinase, Ser/Thr (non-receptor) P70618 81649 20p12 rat T180-p 447970 RHTDDEMtGYVATRW Pkinase activity, induced; enzymatic activity, induced apoptosis, induced; cell growth, altered 10473611; 25371038; 28039298 401 73 1542 +MVB12B FAM125B Vesicle Q9H7P6 89853 9q33.3 human K290-ub 15167003 KSLAEIEkEYEYSFR DUF2464 intracellular localization 20654576 1 4 0 +CXCR4 CXCR4 GPCR, family 1; Membrane protein, integral; Membrane protein, multi-pass; Receptor, GPCR P61073 7852 2q22.1 human K327-ub 6198957 VSRGSSLkILSKGKR protein degradation 24489825 1 5 1 +MARS1 MARS Aminoacyl-tRNA synthetase; EC 6.1.1.10; Ligase; Other Amino Acids Metabolism - selenoamino acid; Translation; Translation regulation P56192 4141 12q13.3 human S209-p 27452641 LQKQPQPsPAEGRAV methylation; enzymatic activity, induced cell growth, induced; transcription, induced; translation, induced 25097229 1 4 0 induces Met-misacylation; reduce intracellular ROS level +CHRM2 mAChR M2 GPCR, family 1; Membrane protein, integral; Membrane protein, multi-pass; Receptor, GPCR P08172 1129 7q33 human S290-p 459105 SNDSTSVsAVASNMR 7tm_1 receptor internalization, altered 9162044 3 0 0 Mutation of S286 T287 S288 S290 to A caused a faster rate and a greater extent of receptor internalization after agonist stimulation (transients only, not observed in stables). Mutation of all 8 sites prevented internalization (in both transients and stables). +APP APP Apoptosis; Cell surface; Membrane protein, integral; Receptor, misc.; Transcription factor P05067 351 21q21.3 human S679-me 1881129801 DAEFRHDsGYEVHHQ molecular association, regulation APP(NOT_REPORTED) 33328587 1 1 0 formaldehyde (FA) cross-linked with K699 residue in the ?-turn of A? monomer to form A? dimers, and then accelerated A? oligomerization +Fbxl21 FBXL21 UBIQUITIN LIGASE; Ubiquitin ligase Q8BFZ4 213311 13|13 B1 mouse T33-p 1870414702 LCSSLRQtHALSVLL enzymatic activity, induced cell differentiation, induced 36574402 2 0 0 induces MYOZ1 degradation +Syngap1 SynGAP GAP; GAP, Ras F6SEU4 240057 17|17 A3.3 mouse S743-p 27720871 RQSERTRsQPMVLRG DUF3498 activity, induced 25533468 1 2 0 phosphorylation of this site increases HRas GAP activity of S88A/T790A/S817A SunGAP mutant +HDAC3 HDAC3 Apoptosis; Cell cycle regulation; DEACETYLASE; Deacetylase; EC 3.5.1.98; Nuclear receptor co-regulator; Transcription, coactivator/corepressor O15379 8841 5q31.3 human S424-p 455624 DHDNDKEsDVEI___ molecular association, regulation; acetylation; enzymatic activity, induced cell cycle regulation KPNA2(INDUCES); PKG1(INDUCES) 15805470; 26356530; 26663086; 27798112; 32772249 6 21 15 +Nfe2l2 NRF2 DNA-binding; Transcription factor Q60795 18024 2 C3|2 44.75 cM mouse S40-p 450082 SREVFDFsQRQKDYE activity, induced; protein stabilization; molecular association, regulation; ubiquitination; intracellular localization carcinogenesis, induced; transcription, induced KEAP1(DISRUPTS) 12947090; 19920073; 33532181; 35165418 33 0 0 +Nphs1 NPHS1 Cell adhesion; Immunoglobulin superfamily; Membrane protein, integral Q9R044 64563 1q21 rat Y1228-p 469566 CEDPRGIyDQVAADM molecular association, regulation cytoskeletal reorganization NCK1(NOT_REPORTED) 16934223; 18256598; 22013520 10 0 0 +ATP7A ATP7A Apoptosis; Cell development/differentiation; Chaperone; EC 3.6.3.54; Hydrolase; Membrane protein, integral; Membrane protein, multi-pass; Transporter; Transporter, ion channel; Vesicle Q04656 538 Xq21.1 human S1466-p 4733428 YSRASINsLLSDKRS protein stabilization; intracellular localization 29301787 2 17 2 translocation to membrane +HIVEP3 HIVEP3 C2H2-type zinc finger protein; Transcription, coactivator/corepressor Q5T1R4 59269 1p34.2 human S542-p 41452307 VPLLRSHsMPSAACT molecular association, regulation 14-3-3 beta(INDUCES); 14-3-3 sigma(INDUCES); 14-3-3 theta(INDUCES); 14-3-3 zeta(INDUCES); 14-3-3 epsilon(INDUCES); 14-3-3 gamma(INDUCES); 14-3-3 eta(INDUCES) 34341191 1 1 0 +MARK2 MARK2 EC 2.7.11.1; EC 2.7.11.26; KINASE; Kinase, protein; Protein kinase, CAMK; Protein kinase, Ser/Thr (non-receptor) Q7KZI7 2011 11q13.1 human S456-p 453135 STAKVPAsPLPGLER cell cycle regulation; carcinogenesis, induced; apoptosis, inhibited 35780183 1 70 15 +FANCA FANCA DNA repair, damage O15360 2175 16q24.3 human S1149-p 9802800 CLRSRDPsLMVDFIL molecular association, regulation 11855836 1 0 0 Complementation assays showed similar results for WT-FANCA and S1149A mutant. +SNAP23 SNAP23 Vesicle O00161 8773 15q15.1-q15.2 human T24-p 11486600 TDESLEStRRILGLA molecular association, regulation STX4(INDUCES) 12930825 1 2 1 +Th TH Amino Acid Metabolism - tyrosine; EC 1.14.16.2; Endoplasmic reticulum; Mitochondrial; Oxidoreductase; Vesicle P24529 21823 7 F5|7 88.06 cM mouse S40-p 448545 RFIGRRQsLIEDARK TOH_N enzymatic activity, induced neural plasticity 17507557; 18674600; 32358047; 33769619 62 11 11 IRL790-induced neurotransmission +Nr3c1 GR DNA-binding; Mitochondrial; Nuclear receptor; Transcription factor P06536 24413 18p11 rat K297-sm 2532301 SVALPQVkTEKDDFI GCR transcription, inhibited 14663148 5 3 0 +Sox4 SOX4 DNA-binding; Transcription factor Q06831 20677 13 A3.1|13 12.87 cM mouse S315-p 50800249 SGRSSAAsSPAASRS protein degradation cell differentiation, induced 34431536 1 1 0 +PREX1 PREX1 GEF; GEF, Rac/Rho Q8TCU6 57580 20q13.13 human S319-p 4735252 KSTKRTKsINGSLYI activity, induced; activity, inhibited 21042280; 27788493 2 8 0 dephosphorylation of serines 313 and 319 negatively regulate GEF activity +Cav1 caveolin-1 Adaptor/scaffold; Motility/polarity/chemotaxis; Nuclear receptor co-regulator P49817 12389 6|6 A2 mouse K176-ub 15489877 NIRISTQkEI_____ molecular association, regulation carcinogenesis, inhibited ABCB1B(INDUCES); caveolin-1(INDUCES) 26843476 1 1 1 Caveolin1 oligomerization induced +Ksr1 KSR KINASE; Kinase, protein; Protein kinase, Ser/Thr (non-receptor); Protein kinase, TKL Q61097 16706 11 B5|11 46.74 cM mouse S297-p 449296 PTLTRSKsHESQLGN molecular association, regulation 14-3-3 beta(INDUCES); 14-3-3 gamma(INDUCES) 28003362; 9858547 3 25 4 +MCC MCC Cell cycle regulation; Tumor suppressor P23508 4163 5q22.2 human S828-p 25126713 RPHTNETsL______ molecular association, regulation; intracellular localization cytoskeletal reorganization Scribble(INDUCES) 22480440 1 4 0 reduced lamellipodia formation, modified MyosinII-B localization +Ccnd2 CCND2 Cell cycle regulation; Motility/polarity/chemotaxis P30280 12444 6 F3|6 61.92 cM mouse T280-p 469202 EDPDQATtPTDVRDV Cyclin_C protein degradation; intracellular localization 17452458 4 3 11 degradation of itself and p27Kip1 +Scn10a SCN10A Channel, sodium; Membrane protein, integral; Membrane protein, multi-pass Q62968 rat S556-p 2482301 PRSPLPQsPNPGRRH activity, induced 18354022 1 0 0 increases SCN10A sodium channel current density +PML PML Nucleolus; Oncoprotein; SUMO LIGASE; SUMO conjugating system; SUMO ligase; Transcription factor; Tumor suppressor; Ubiquitin conjugating system P29590 5371 15q24.1 human S505-p 468479 EARLARSsPEQPRPS DUF3583 molecular association, regulation C/EBP-epsilon(INDUCES) 17989716 1 41 20 +PAK6 PAK6 EC 2.7.11.1; KINASE; Kinase, protein; Nuclear receptor co-regulator; Protein kinase, STE; Protein kinase, Ser/Thr (non-receptor) Q9NQU5 56924 15q15.1 human S308-p 29666302 SLVAKAQsLPSDQPV molecular association, regulation; enzymatic activity, induced carcinogenesis, induced; cell motility, induced AR(INDUCES) 24130878 1 1 0 promotion of cell motility and invasion +HDAC5 HDAC5 DEACETYLASE; Deacetylase; EC 3.5.1.98; Hydrolase Q9UQL6 10014 17q21.31 human S661-p 7237900 QALGRTQsSPAAPGG intracellular localization 14-3-3 beta(INDUCES) 18951085 2 16 24 14-3-3-dependent nuclear export +FOXO3 FOXO3A Autophagy; DNA-binding; Oncoprotein; Transcription factor O43524 2309 6q21 human S209-p 464289 SSAGWKNsIRHNLSL Forkhead molecular association, regulation; intracellular localization 14-3-3 beta(DISRUPTS) 16751106 4 0 0 +BRAF BRAF EC 2.7.11.1; KINASE; Kinase, protein; Oncoprotein; Protein kinase, Ser/Thr (non-receptor); Protein kinase, TKL P15056 673 7q34 human T440-p 447806 EDRNRMKtLGRRDSS enzymatic activity, inhibited 10869359; 11293329 2 2 5 +ATP7B ATP7B EC 3.6.3.54; Hydrolase; Membrane protein, integral; Membrane protein, multi-pass; Transporter; Transporter, ion channel; Vesicle P35670 540 13q14.3 human S481-p 11267006 ILAKSPQsTRAVAPQ protein stabilization; intracellular localization 21189263 1 4 0 protein trafficking +SAV1 SAV1 Adaptor/scaffold Q9H4B6 60485 14q22.1 human T26-p 4270990 GKYVKKEtSPLLRNL protein conformation apoptosis, induced 21944251 1 3 0 self-dimerization; increase in protein level +MAP2K1 MEK1 EC 2.7.12.2; KINASE; Kinase, protein; Protein kinase, STE; Protein kinase, dual-specificity (non-receptor) Q02750 5604 15q22.31 human S218-p 448514 VSGQLIDsMANSFVG Pkinase intracellular localization; protein conformation; phosphorylation; enzymatic activity, induced cell cycle regulation; carcinogenesis, induced; cell growth, induced; transcription, induced; signaling pathway regulation; cell growth, altered 12466969; 12506122; 12609989; 16585161; 17667937; 19106095; 21893193; 24681949; 27323830; 32076487; 33789117; 33808483; 34262144; 34470822; 35173310; 7731726; 8621729 124 13 83 +Stx1b STX1B Membrane protein, integral; Vesicle P61265 24923 1q37 rat S14-p 450122 ELRSAKDsDDEEEVV molecular association, regulation SNAP-25(INDUCES) 10844023 2 19 5 +Cebpb C/EBP-beta DNA-binding; Motility/polarity/chemotaxis; Transcription factor P28033 12608 2 H3|2 87.58 cM mouse S222-p 408589401 KKTVDKLsDEYKMRR bZIP_2 transcription, induced DNA(INDUCES) 29259016 1 1 0 L-6, IL-1a, Cxcl1, Cxcl2, and Ccr1 +NOX5 NOX5 iso4 EC 1.6.3.-; Membrane protein, integral; Membrane protein, multi-pass; Oxidoreductase Q96PH1-4 79400 15q23 human S475-p 20612400 WTNRLYEsFKASDPL FAD_binding_8 enzymatic activity, induced 21642394 1 1 0 ROS production +PTPN1 PTP1B EC 3.1.3.48; Motility/polarity/chemotaxis; PHOSPHATASE; Phosphatase; Protein phosphatase, tyrosine (non-receptor) O13016 395688 chicken Y152-p 449312 ISEDIKSyYTVRQLE Y_phosphatase molecular association, regulation CDH2(INDUCES) 11106648 5 0 1 +CEBPE C/EBP-epsilon DNA-binding; Motility/polarity/chemotaxis; Transcription factor Q15744 1053 14q11.2 human K121-ac 38557701 DPRAVAVkEEPRGPE molecular association, regulation cell differentiation, induced; transcription, induced DNA(INDUCES) 25568349; 31256937 2 1 0 deletion of R247 or S248 was sufficient for the loss of C/EBPe transcriptional activity, TSA treatment may be able restore the transcriptional activity +FUS hnRNP P2 DNA-binding; Nuclear receptor co-regulator; Oncoprotein; RNA splicing; RNA-binding; SUMO LIGASE P35637 2521 16p11.2 human S182-p 1878186704 GNYGQDQsSMSSGGG molecular association, regulation hnRNP P2(DISRUPTS) 35753345 1 1 0 +Ppargc1b PGC-1 beta Nuclear receptor co-regulator; Transcription, coactivator/corepressor Q8VHJ7 170826 18|18 E1 mouse K994-ac 7761207 ESLPSSGkSKYEAMD intracellular localization transcription, inhibited 19491097 1 1 0 +NOXA1 NOXA1 Activator Q86UR1 10811 9q34.3 human Y110-p 17303900 RGHAAIDyTQLGLRF activity, induced; molecular association, regulation carcinogenesis, altered; cytoskeletal reorganization SH3PXD2B(INDUCES) 20943948 1 0 0 +KDM4C JMJD2C DEMETHYLASE; Demethylase; EC 1.14.11.-; Oxidoreductase Q9H3R0 23081 9p24.1 human S918-p 1869778705 MFDDGSFsRDTFPED protein degradation; molecular association, regulation; ubiquitination signaling pathway regulation BTRC(INDUCES) 31888886 1 0 0 +BCL10 Bcl-10 Apoptosis; Transcription, coactivator/corepressor; Tumor suppressor O95999 8915 1p22.3 human S231-p 469573 PLRSRTVsRQ_____ molecular association, regulation; intracellular localization Bcl-3(INDUCES) 16280327 1 0 1 +UHRF1 UHRF1 DNA-binding; EC 6.3.2.-; EC 6.3.2.19; Ligase; Transcription factor; UBIQUITIN LIGASE; Ubiquitin conjugating system; Ubiquitin ligase Q96T88 29128 19p13.3 human S95-p 3210060 SELSDTDsGCCLGQS protein degradation; molecular association, regulation BTRC(INDUCES) 23297342 1 10 5 +MAP3K2 MEKK2 EC 2.7.11.25; KINASE; Kinase, protein; Protein kinase, STE; Protein kinase, Ser/Thr (non-receptor) Q9Y2U5 10746 2q14.3 human S520-p 1869000 LSGTGMKsVTGTPYW Pkinase phosphorylation; enzymatic activity, induced transcription, altered 16362041 2 3 0 Mutation of S520A inhibits activation and is the key residue. Double mutation of T522A,T524A reduces activation effect. T522A seems to have the least effect of the three single mutations. The triple STT to AAA mutation is akin to kinase dead. Activation leads to Erk5 and JNKK2 phosphorylation/activation. +TRIM28 TIF1B EC 6.3.2.-; KINASE; Kinase, protein; Ligase; Nuclear receptor co-regulator; Protein kinase, atypical; SUMO LIGASE; SUMO ligase; Transcription, coactivator/corepressor; UBIQUITIN LIGASE; Ubiquitin conjugating system; Ubiquitin ligase Q13263 10155 19q13.43 human Y449-p 3576406 PMEVQEGyGFGSGDD molecular association, regulation; phosphorylation DNA repair, induced HP1 alpha(INDUCES) DNA(NOT_REPORTED) 23645696 1 2 2 stimulates phosphorylation of TIF1B S473 and TIF1B S824 in DNA damage response; involved in DNA damage response; inhibits association of HP1alpha with chromatin +Dok1 DOK1 Adaptor/scaffold; Motility/polarity/chemotaxis P97465 13448 6 C3|6 35.94 cM mouse Y146-p 455786 EMLENSLySPTWEGS molecular association, regulation cell cycle regulation; cell motility, altered; cell growth, altered DOK1(INDUCES) 11042170; 18515860 2 1 2 +ERBB3 HER3 EC 2.7.10.1; KINASE; Kinase, protein; Membrane protein, integral; Oncoprotein; Protein kinase, TK; Protein kinase, tyrosine (receptor) P21860 2065 12q13.2 human Y1222-p 448639 SSLEELGyEYMDVGS molecular association, regulation; enzymatic activity, induced carcinogenesis, induced; cell growth, induced; cell motility, induced; apoptosis, inhibited; signaling pathway regulation PIK3R2(INDUCES); PIK3R1(INDUCES) 16729043; 21725367; 34320350 5 0 1 induces ERBB3/PI3K/mTOR pathway; chemotaxis and invasion +Jund JunD Motility/polarity/chemotaxis; Transcription factor P15066 16478 8 B3.3|8 34.15 cM mouse T117-p 473545 SNGLVTTtPTSTQFL Jun transcription, altered 14676207 1 2 4 +CEP192 CEP192 Cell cycle regulation; Microtubule-binding Q8TEP8 55125 18p11.21 human S995-p 41159606 TSPLSHSsPSEISGT molecular association, regulation cell cycle regulation; cytoskeletal reorganization PLK1(INDUCES) 26012549 1 0 0 required for proper spindle formation and mitotic progression +Ppp1r1b DARPP-32 Motility/polarity/chemotaxis; Protein phosphatase, regulatory subunit Q60829 19049 11|11 D mouse S130-p 448046 EEDEEEDsQAEVLKG DARPP-32 activity, induced 11572969 13 4 15 +Nlgn2 NLGN2 Membrane protein, integral Q62888 117096 10q24 rat Y770-p 7294539 RPACPPDyTLALRRA activity, inhibited 27805570 1 0 2 enhancement of inhibitory currents +Ipo13 IPO13 Karyopherin; Nuclear export; Nuclear import Q9JM04 116458 5q36 rat S193-p 15420334 RKGLVRAsLAVECGA Xpo1 molecular association, regulation; intracellular localization; protein conformation ARX(INDUCES); PAX6(INDUCES) 30045875 1 0 1 increases cytoplasmic localization of IPO13 and inhibits its nuclear import +NOXO1 NOXO1 iso3 Adaptor/scaffold Q8NFA2-3 124056 16p13.3 human T341-p 28758706 AIQSRCCtVTRRALE molecular association, regulation NOXA1(INDUCES) 23957209 1 1 0 +JUNB JunB Motility/polarity/chemotaxis; Oncoprotein; Transcription factor P17275 3726 19p13.13 human Y173-p 41655503 PAGPGGVyAGPEPPP Jun transcription, induced 26217035 1 1 0 p21 promoter activity upon Adriamycin stimulation +Itga4 ITGA4 Cell adhesion; Membrane protein, integral; Motility/polarity/chemotaxis; Receptor, misc. Q00651 16401 2 C3|2 47.38 cM mouse R471-me 1883354000 SAVLLRTrPVVIVEA transcription, inhibited 36191854 1 1 0 R471 methylation suppresses pro?brotic gene expression +WEE1 Wee1 EC 2.7.10.2; KINASE; Kinase, protein; Protein kinase, Other; Protein kinase, Ser/Thr (non-receptor); Protein kinase, tyrosine (non-receptor) P30291 7465 11p15.4 human S53-p 451131 GHSTGEDsAFQEPDS protein degradation; molecular association, regulation cell cycle regulation BTRC(INDUCES); FBW1B(INDUCES) 15070733; 15350223; 16085715 4 0 1 +GRK2 GRK2 EC 2.7.11.15; KINASE; Kinase, protein; Protein kinase, AGC; Protein kinase, Ser/Thr (non-receptor) P25098 156 11q13.2 human K21-ub 1872283502 LMAMEKSkATPAARA protein degradation 17006543 1 0 0 +Map3k4 MEKK4 EC 2.7.11.25; KINASE; Kinase, protein; Protein kinase, STE; Protein kinase, Ser/Thr (non-receptor) O08648 26407 17 8.42 cM|17 A1 mouse T1483-p 479428 KLKNNAQtMPGEVNS Pkinase molecular association, regulation; enzymatic activity, induced GADD45A(INDUCES) 27358404 2 2 1 +TP53 p53 Activator; DNA-binding; Motility/polarity/chemotaxis; Nuclear receptor co-regulator; Transcription factor; Tumor suppressor P04637 7157 17p13.1 human S183-p 18675301 CPHHERCsDSDGLAP P53 protein degradation; molecular association, regulation; ubiquitination cell cycle regulation; carcinogenesis, induced; apoptosis, inhibited; transcription, inhibited DNA(DISRUPTS) 22611192; 32873634 3 1 0 +Rb1 Rb Nuclear receptor co-regulator; Oncoprotein; Transcription, coactivator/corepressor; Tumor suppressor P13405 19645 14 38.73 cM|14 D3 mouse S788-p 447979 SPYKFSSsPLRIPGG Rb_C molecular association, regulation E2F1(DISRUPTS) 10207050 52 17 94 +AURKAIP1 AKIP Cell cycle regulation Q9NWT8 54998 1p36.33 human S70-p 999611 MLVPRKMsVSPLESW protein stabilization 17957726 1 1 0 +VAV1 VAV1 GEF; GEF, Rac/Rho; Motility/polarity/chemotaxis; Oncoprotein P15498 7409 19p13.3 human Y745-p 13209302 LTELVEFyQQNSLKD SH2 cell differentiation, altered; cell motility, altered 20028078 2 1 0 +UTRN utrophin Dystrophin complex; Motility/polarity/chemotaxis P46939 7402 6q24.2 human S1258-p 2525745 TLEERMKsTEVLPEK molecular association, regulation DAG1(INDUCES) 19945424 1 3 0 +FHL1 FHL1 iso1 Cell development/differentiation Q13642-1 2273 Xq26.3 human Y149-p 15410160 FPKGEDFyCVTCHET LIM intracellular localization cell growth, induced BCLAF1(INDUCES) 29434030 1 0 2 translocate to the nucleus +EPHB1 EphB1 EC 2.7.10.1; KINASE; Kinase, protein; Membrane protein, integral; Protein kinase, TK; Protein kinase, tyrosine (receptor) P54762 2047 3q22.2 human Y600-p 450470 IYIDPFTyEDPNEAV EphA2_TM molecular association, regulation SHC1(NOT_REPORTED); Src(NOT_REPORTED) 12925710 1 17 120 +NCAPG NCAPG Cell cycle regulation Q9BPX3 64151 4p15.31 human T308-p 5014903 LNALFSItPLSELVG molecular association, regulation; intracellular localization DNA(INDUCES) 18977199 1 0 0 regulates NCAPG localization with chromosomal DNA in mitotic cells +SLC9A5 NHE5 Membrane protein, integral; Membrane protein, multi-pass; Transporter; Transporter, SLC family Q14940 6553 16q22.1 human S577-p 34424902 NLLRESGsGACLDLQ activity, induced 24936055 1 0 0 metabolic stress-induced activation +AURKC AurC EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, Other; Protein kinase, Ser/Thr (non-receptor) Q9UQB9 6795 19q13.43 human T202-p 469107 RRKTMCGtLDYLPPE Pkinase enzymatic activity, induced 27332895 3 6 15 +Hist1h2ail1 H3 DNA-binding Q6LED0 291159 17p11 rat K27-ac 465521 LATKAARkSAPATGG Histone molecular association, regulation DNA(INDUCES) 23382250 74 18 13 +Notch1 Notch 1 Membrane protein, integral; Motility/polarity/chemotaxis; Oncoprotein; Receptor, misc.; Transcription factor Q01705 18128 2 A3|2 18.91 cM mouse K2146-ac 18899508 LKSATQGkKARKPST protein stabilization; ubiquitination 21499261 1 1 0 +SNIP1 SNIP1 Inhibitor Q8TAD8 79753 1p34.3 human K30-sm 15513209 LPAGVVVkQERLSPE molecular association, regulation cell motility, induced; transcription, induced 27703003 1 4 0 SUMOylation decreases the inhibitory effect of SNIP1 on TGF-beta-induced formation of the Smad2/4 and Smad3/4 complexes +MSH3 MSH3 DNA repair, damage P20585 4437 5q14.1 human K123-ac 9930501 SGNSEPKkCLRTRNV intracellular localization 32900932 1 0 1 +CALR Calreticulin ACETYLTRANSFERASE; Acetyltransferase; Calcium-binding; Motility/polarity/chemotaxis; Nuclear receptor co-regulator; Secreted; Secreted, signal peptide P27797 811 19p13.13 human K159-ac 4219807 GKNVLINkDIRCKDD Calreticulin protein conformation 18795239 1 5 2 +RPL11 RPL11 Motility/polarity/chemotaxis; Nucleolus; Ribosomal; Translation P62913 6135 1p36.11 human K19-ne 12067600 MRELRIRkLCLNICV Ribosomal_L5 protein stabilization; intracellular localization 19713960 1 0 0 +HSF1 HSF1 DNA-binding; Transcription factor Q00613 3297 8q24.3 human S292-p 455481 DERPLSSsPLVRVKE Vert_HS_TF transcription, inhibited 25963659 3 5 1 under non-stressed conditions, upon heat shock S to A mutant showed 60% higher luciferase activity +NFE4 NF-E4 Q86UQ8 58160 7q22.1 human K43-ub 486332 DLPLRPRkQATAAGQ protein stabilization; molecular association, regulation; ubiquitination transcription, induced HDAC1(DISRUPTS) 15273251 1 0 0 inhibits NF-E4 ubiquitination +GRIN2A NMDAR2A Channel, ligand-gated; Membrane protein, integral; Membrane protein, multi-pass Q12879 2903 16p13.2 human Y1387-p 455471 GRCPSDPyKHSLPSQ NMDAR2_C activity, induced 10195142; 33037073 6 1 13 potentiation of receptor currents mediated by Src; leptin-induced beta-cell membrane potentiation +CEBPB C/EBP-beta DNA-binding; Motility/polarity/chemotaxis; Transcription factor P17676 1051 20q13.13 human T266-p 448447 VKSKAKKtVDKHSDE molecular association, regulation DNA(INDUCES) 15738002 4 0 0 +LRP1 LRP1 Cell surface; Membrane protein, integral; Motility/polarity/chemotaxis; Receptor, misc. Q07954 4035 12q13.3 human T4460-p 12526700 GFQHQRMtNGAMNVE molecular association, regulation; receptor internalization, altered GULP1(INDUCES); DAB1(INDUCES); SHC1(INDUCES) 15272003 1 4 1 +MVB12A FAM125A Adaptor/scaffold Q96EY5 93343 19p13.11 human Y204-p 469592 LRRNDSIyEASSLYG DUF2464 molecular association, regulation; intracellular localization cytoskeletal reorganization SH3KBP1(INDUCES); CD2AP(INDUCES) 16895919 1 10 58 important for ligand-mediated EGFR internalization and downregulation +CDKN1B p27Kip1 Cell cycle regulation; Inhibitor; Oncoprotein; Protein kinase, regulatory subunit P46527 1027 12p13.1 human Y74-p 475060 HKPLEGKyEWQEVEK CDI protein degradation; molecular association, regulation; phosphorylation cell cycle regulation CDK4(DISRUPTS); CCND1(INDUCES); CDK2(DISRUPTS); CDK4(INDUCES); CCNE1(DISRUPTS) 17254967; 18710949; 21423803; 22276948 10 0 0 +FOXO3 FOXO3A Autophagy; DNA-binding; Oncoprotein; Transcription factor O43524 2309 6q21 human S425-p 2058400 TKGSGLGsPTSSFNS protein degradation; molecular association, regulation; activity, inhibited cell growth, altered MDM2(INDUCES) 18204439 4 10 0 promotes tumorigenicity +Myl9 MRLC1 Contractile; Motility/polarity/chemotaxis Q64122 296313 3q42 rat T19-p 1863501 KKRPQSAtSNVFAMF cytoskeletal reorganization 21887379 28 53 281 T19, S20 di-phosphorylation is recquired for dendritic spine maturation; mono phosphorylation inhibits spine maturation. +G6PD G6PD Carbohydrate Metabolism - pentose phosphate pathway; Cell development/differentiation; EC 1.1.1.49; Other Amino Acids Metabolism - glutathione; Oxidoreductase P11413 2539 Xq28 human K171-ac 3648857 WNRIIVEkPFGRDLQ G6PD_N enzymatic activity, inhibited; enzymatic activity, altered carcinogenesis, inhibited; cell growth, inhibited 33630390; 37798264 2 7 3 K171Q mutant reduces tumor growth when expressed in nude mice. +WAS WASP Adaptor/scaffold; Motility/polarity/chemotaxis P42768 7454 Xp11.23 human K76-sm 52504001 CGAVCFVkDNPQKSY WH1 molecular association, regulation; acetylation transcription, altered; signaling pathway regulation COMMD1(DISRUPTS); HDAC6(DISRUPTS) 26261240 1 0 0 induces hypoacetylation at H3K14, regulates NF-kB signaling +PLA2G4A PLA2G4A EC 3.1.1.4; EC 3.1.1.5; Lipid Metabolism - alpha-linolenic acid; Lipid Metabolism - arachidonic acid; Lipid Metabolism - ether lipid; Lipid Metabolism - glycerophospholipid; Lipid Metabolism - linoleic acid; Phospholipase P47712 5321 1q31.1 human S505-p 447597 LNTSYPLsPLSDFAT PLA2_B activity, induced; intracellular localization; protein conformation; enzymatic activity, induced carcinogenesis, induced; cytoskeletal reorganization; signaling pathway regulation; cell growth, altered KSR(INDUCES) 12885780; 14530366; 18280113; 18632668; 18775330; 19176526; 32559461; 35408744; 36351818; 7766652 25 6 8 required for formation of lipid droplets; regulates mTORC2-PKC?-cPLA2 signaling; PLA2 binding to KSR1 is mediated by ERK . +MLKL MLKL KINASE; Kinase, protein; Protein kinase, Ser/Thr (non-receptor); Protein kinase, TKL Q8NB16 197259 16q23.1 human S358-p 22996309 ELRKTQTsMSLGTTR PK_Tyr_Ser-Thr molecular association, regulation; intracellular localization; protein conformation carcinogenesis, inhibited; apoptosis, induced; transcription, induced; cell motility, inhibited; signaling pathway regulation MLKL(INDUCES) 22265413; 24703947; 26184911; 28758999; 30029665; 34155344 36 3 0 triggers necroptosis in TNBC cells; induces through the necrosis pathway; oligomer formation during necrosis, binds membrane lipids; necroptosis induced +CEBPE C/EBP-epsilon DNA-binding; Motility/polarity/chemotaxis; Transcription factor Q15744 1053 14q11.2 human K121-sm 12004436 DPRAVAVkEEPRGPE activity, induced transcription, induced 12161447; 15661739 2 0 0 +TBC1D1 TBC1D1 DEUBIQUITINASE; GAP; GAP, Rab; Ubiquitin-specific protease Q86TI0 23216 4p14 human T596-p 1247778 AFRRRANtLSHFPIE molecular association, regulation 14-3-3 sigma(INDUCES) 17995453 11 13 137 +C5AR1 C5aR GPCR, family 1; Membrane protein, integral; Membrane protein, multi-pass; Receptor, GPCR P21730 728 19q13.32 human S332-p 448822 EESVVREsKSFTRST molecular association, regulation; receptor desensitization, altered ARRB1(INDUCES); ARRB2(INDUCES) 10636859; 12464600; 17145764 4 8 0 induces translocation of beta-arrestin into the plasma membrane +ATG4B ATG4B Autophagy; EC 3.4.22.-; Protease; Ubiquitin conjugating system Q9Y4P1 23192 2q37.3 human S316-p 2527072 SIAELDPsIAVGFFC Peptidase_C54 molecular association, regulation LC3B(DISRUPTS) 28821708 1 1 0 +KAT2A GCN5 ACETYLTRANSFERASE; Acetyltransferase; EC 2.3.1.48 Q92830 2648 17q21.2 human T272-p 33703200 LNYWKLEtPAQFRQR PCAF_N acetylation; enzymatic activity, induced 24870244 1 0 0 enhanced acetyltransferase acivity, PGC-1a acetylation, suppresses gluconeogenesis +ERBB4 HER4 EC 2.7.10.1; KINASE; Kinase, protein; Membrane protein, integral; Protein kinase, TK; Protein kinase, tyrosine (receptor) Q15303 2066 2q34 human Y1150-p 458100 GELDEEGyMTPMRDK molecular association, regulation Arg(INDUCES); Syk(INDUCES); CRK(INDUCES) 18721752 0 2 4 +Syngap1 SynGAP GAP; GAP, Ras Q9QUH6 192117 20p12 rat S1108-p 8098868 PARPRQQsLSKEGSI DUF3498 molecular association, regulation; intracellular localization PSD-95(DISRUPTS) 25569349 2 2 1 SynGAP dispersion from dendritic spines, Ras activity and GluA1 tafficking during LTP +EGFR EGFR EC 2.7.10.1; KINASE; Kinase, protein; Membrane protein, integral; Oncoprotein; Protein kinase, TK; Protein kinase, tyrosine (receptor) P00533 1956 7p11.2 human K1179-ac 14991103 YQQDFFPkEAKPNGI receptor internalization, induced; phosphorylation endocytosis, induced; signaling pathway regulation 20513767 1 1 0 induces AKT phosphorylation and hence ERK1/2 signaling +JAK2 JAK2 EC 2.7.10.2; KINASE; Kinase, protein; Oncoprotein; Protein kinase, TK; Protein kinase, tyrosine (non-receptor) O60674 3717 9p24.1 human K167-sm 31899102 DFVHGWIkVPVTHET FERM_F2 molecular association, regulation; intracellular localization GH receptor(DISRUPTS) 23581279 1 0 0 translocation into the nucleus +PPP2CA PPP2CA EC 3.1.3.16; Motility/polarity/chemotaxis; PHOSPHATASE; Protein phosphatase, Ser/Thr (non-receptor) P67775 5515 5q31.1 human K136-ac 50286947 FYDECLRkYGNANVW Metallophos enzymatic activity, induced 34740611 1 0 1 +Ptk2b Pyk2 EC 2.7.10.2; KINASE; Kinase, protein; Nuclear receptor co-regulator; Protein kinase, TK; Protein kinase, tyrosine (non-receptor) P70600 50646 15p12 rat Y579-p 447956 RYIEDEDyYKASVTR PK_Tyr_Ser-Thr enzymatic activity, induced 11337490 7 28 947 +SMAD2 SMAD2 DNA-binding; Transcription factor Q15796 4087 18q21.1 human S467-p 447495 SVRCSSMs_______ activity, induced; molecular association, regulation; intracellular localization carcinogenesis, induced; cell differentiation, induced; transcription, induced; transcription, altered TGFBR1(DISRUPTS); SMAD4(INDUCES) 11043574; 21996745; 31995604; 33963314; 35075279; 36461015; 8980228; 9346908; 9346966 57 1 5 S464 not likely phosphorylated but is required for efficient phosphorylation of COOH terminus. +Dab1 DAB1 Adaptor/scaffold Q8CJH2 266729 5q33-q34 rat S491-p 479422 TPAPRQSsPSKSSAS molecular association, regulation CD2AP(DISRUPTS); SH3KBP1(DISRUPTS) 18076569 7 0 0 +Kcna4 Kv1.4 Channel, potassium; Membrane protein, integral; Membrane protein, multi-pass P15385 25469 3q33 rat S229-p 457537 FFDRNRPsFDAILYY BTB_2 intracellular localization 16000151 1 0 1 Kv1.4 with wild-type S229 or S229A had significant difference in current density but not in membrane potential or current shape authors suggest that S229 is important to prevent Kv1.4 from trafficing to the membrane. +TIFA TIFA Q96CG3 92610 4q25 human T9-p 50409900 TSFEDADtEETVTCL activity, induced; molecular association, regulation; ubiquitination; intracellular localization; protein conformation; phosphorylation signaling pathway regulation TIFA(INDUCES); TRAF2(INDUCES); CASP1(INDUCES); TRAF6(INDUCES) 26389808; 27965388; 28069801; 28514661; 28877472; 29581234; 30111836; 36098982 9 1 0 induces IKK and JNK phosphorylation; oligomerization; TIFA oligomerization; activates TRAF6-dependent NF-kB signalling; pThr9 for TIFA oligomerization around DNA damage sites could enhance the efficiency of NEMO ubiquitination upon genotoxic stress.; aggregation; TIFA oligomerization, promote the assembly of NLRP3 inflammasome; p65 translocation and TIFAsome formation; regulates ADP-heptose signaling +SP1 SP1 C2H2-type zinc finger protein; DNA-binding; Transcription factor P08047 6667 12q13.13 human T739-p 448227 SEGSGTAtPSALITT protein degradation; molecular association, regulation; protein stabilization; ubiquitination; intracellular localization; phosphorylation cell differentiation, inhibited; cell cycle regulation; cell growth, inhibited; apoptosis, induced; transcription, induced; transcription, altered; cell growth, induced; transcription, inhibited MYO3A(INDUCES); RNF4(DISRUPTS); ACTB(INDUCES); PIN1(INDUCES) DNA(DISRUPTS) 11904305; 14593115; 14744793; 18199680; 19245816; 19372209; 20150555; 21983342; 22266860; 25398907; 32205409 17 1 0 inhibits transcription of p16, p21 and SDH5; induces phosphorylation at other sites on the protein; reduces binding to FBXL2 promoter +MALT1 MALT1 Adaptor/scaffold; Apoptosis; EC 3.4.22.-; Ligase; Nuclear export; Protease; UBIQUITIN LIGASE; Ubiquitin conjugating system Q9UDY8 10892 18q21.32 human S570-p 1870751202 PIQGTEYsAESLVRN Peptidase_C14 carcinogenesis, induced; cell growth, induced; transcription, induced; signaling pathway regulation 31644910 0 1 0 activates transcription of NF-kB +Kalrn kalirin EC 2.7.11.1; GEF; GEF, Rac/Rho; KINASE; Kinase, protein; Protein kinase, CAMK; Protein kinase, Ser/Thr (non-receptor) P97924 84009 11q22 rat T1572-p 3363402 EPIQLPKtPAKLRNN cell growth, altered 18628310 1 0 1 T1590D mutation increases Trad solubility +Parva PARVA Adaptor/scaffold; Motility/polarity/chemotaxis Q9HB97 57341 1q33 rat S8-p 4270099 MATSPQKsPSVPKSP intracellular localization 30515554 4 33 0 cell morphology changes-found near nucleus dependent on decidualisation +Itpr1 IP3R1 Channel, calcium; Channel, ligand-gated; Membrane protein, integral; Membrane protein, multi-pass P29994 25262 4q41 rat S1756-p 450682 RPSGRREsLTSFGNG activity, induced; receptor inactivation, altered 12167631; 15308649 13 24 15 Mutation of site to Glu enhanced, while mutation to Ala inhibited, calcium release through IP3R1.; increases the open probability of the IP3R receptor Ca(2+) channel +SLC9A5 NHE5 Membrane protein, integral; Membrane protein, multi-pass; Transporter; Transporter, SLC family Q14940 6553 16q22.1 human T714-p 20832302 EESDSSEtEKEDDEG molecular association, regulation; activity, inhibited endocytosis, induced ARRB1(INDUCES) 21296876 1 0 0 +Chuk IKKA EC 2.7.11.10; KINASE; Kinase, protein; Protein kinase, Other; Protein kinase, Ser/Thr (non-receptor) Q60680 12675 19 C3|19 36.71 cM mouse S176-p 447778 AKDVDQGsLCTSFVG Pkinase cell differentiation, inhibited; apoptosis, induced; transcription, induced; transcription, altered 35449211; 35637461; 36309088 34 1 0 +HNRNPA1 hnRNP A1 Nuclear export; RNA splicing; RNA-binding; Spliceosome P09651 3178 12q13.13 human R218-m2 4153100 GGNDNFGrGGNFSGR molecular association, regulation Ebp1(INDUCES); CCND1(INDUCES) 31473880 2 5 18 +RAC1 RAC1 G protein; G protein, monomeric; G protein, monomeric, Rho; Motility/polarity/chemotaxis P63000 5879 7p22.1 human K147-ub 2142500 PQGLAMAkEIGAVKY Ras protein degradation; enzymatic activity, inhibited cell motility, inhibited 18093184; 22614015 3 12 26 +DROSHA DROSHA EC 3.1.26.3; Nucleolus; RNA processing; RNA-binding; Ribonuclease Q9NRR4 29102 5p13.3 human T274-p 25289827 SDYDRGRtPSRHRSY molecular association, regulation DGCR8(DISRUPTS) 25699712 1 1 1 +NCOA6 NCOA6 Nuclear receptor co-regulator; Transcription, coactivator/corepressor Q14686 23054 20q11.22 human S884-p 470103 NKDVTLTsPLLVNLL molecular association, regulation transcription, altered ER-alpha(DISRUPTS); ER-beta(INDUCES) 11773444 1 2 0 S884Y mutation had significant increase in binding to TRB,RXR, and ER-beta, but decreased binding to ER-alpha. Transcriptional activity of S884Y is associated with its receptor binding affinity. S884 may interact with E380 of ER-alpha demonstrated by molecular modeling. +Zc3hav1 ZAP RNA-binding; Transferase Q8K3Y6 252832 4q22 rat S257-p 469059 RDRFLHNsLEFLSPV activity, induced 22514281 1 23 39 +YAP1 YAP1 iso2 Oncoprotein; Transcription, coactivator/corepressor P46937-2 10413 11q22.1 human S127-p 448847 PQHVRAHsSPASLQL activity, induced; protein degradation; molecular association, regulation; intracellular localization; activity, inhibited carcinogenesis, inhibited; cell differentiation, induced; cell growth, inhibited; transcription, inhibited 14-3-3 beta(INDUCES) 19141641; 20048001; 21909427; 23027127; 23752589 207 33 180 +MYL12A MRLC3 Contractile P19105 10627 18p11.31 human Y142-p 11102602 DEEVDELyREAPIDK EF-hand_11 intracellular localization 32502416 1 3 1 +L3MBTL2 L3MBTL2 Histone-binding Q969R5 83746 22q13.2 human K700-sm 31089507 PVSVENIkQETDD__ ubiquitination transcription, inhibited 24369422 2 4 0 induces Histone ubiquitination +MARK2 MARK2 EC 2.7.11.1; EC 2.7.11.26; KINASE; Kinase, protein; Protein kinase, CAMK; Protein kinase, Ser/Thr (non-receptor) Q7KZI7 2011 11q13.1 human T208-p 449999 TFGNKLDtFCGSPPY Pkinase molecular association, regulation; protein conformation; enzymatic activity, induced CBP(DISRUPTS) 22238344; 28711359; 35469920 11 48 47 +AHR AHR DNA-binding; Transcription factor P35869 196 7p21.1 human Y322-p 455230 LCTRGSGyQFIHAAD PAS_3 activity, induced transcription, induced 21703235 2 0 0 Induce AHR activation +PLEKHG1 PLEKHG1 GEF; GEF, Rac/Rho Q9ULL1 57480 6q25.1 human Y661-p 15502837 IDDIDHVyDNISYED activity, induced; molecular association, regulation; intracellular localization cytoskeletal reorganization Fyn(INDUCES) 35031323 1 0 1 +CTNND1 CTNND1 iso3 Actin-binding; Adaptor/scaffold; Cell adhesion; G protein regulator, misc.; Motility/polarity/chemotaxis O60716-3 1500 11q12.1 human S268-p 450453 PQVRVGGsSVDLHRF molecular association, regulation signaling pathway regulation Kaiso(INDUCES); CDH1(DISRUPTS) 21670201 12 73 56 prevents Kaiso binding to Tcf-4 and B-catenin, induces Kaiso binding to CDKN2A promoter, inhibiting CDKN2A gene expression +Tyrobp TYROBP Cell surface; Membrane protein, integral O54885 22177 7 B1|7 17.45 cM mouse Y92-p 451788 IAETESPyQELQGQR molecular association, regulation DOK3(INDUCES) 23962980 1 9 251 +YAP1 YAP1 Oncoprotein; Transcription, coactivator/corepressor P46937 10413 11q22.1 human S109-p 452305 KSHSRQAsTDAGTAG protein degradation; intracellular localization carcinogenesis, altered; cell growth, inhibited; apoptosis, induced; transcription, altered; signaling pathway regulation; cell growth, induced; cell motility, altered; transcription, inhibited; cell growth, altered 24658687; 25660024; 28416665; 33630828; 36588499 23 63 341 regulates AR signaling +PPARG PPAR-gamma iso2 DNA-binding; Nuclear receptor; Transcription factor P37231-2 5468 3p25.2 human S245-p 15175800 TGKTTDKsPFVIYDM protein conformation 25954810 26 2 0 +FEN1 FEN1 DNA repair, damage; DNA-binding; Deoxyribonuclease; EC 3.1.-.-; Nuclear receptor co-regulator; Nucleolus; Ribonuclease P39748 2237 11q12.2 human K168-sm 25724402 ASCAALVkAGKVYAA XPG_I protein degradation; ubiquitination 22749529 1 1 0 +BCL10 Bcl-10 Apoptosis; Transcription, coactivator/corepressor; Tumor suppressor O95999 8915 1p22.3 human S144-p 15408027 NSDESNFsEKLRAST activity, induced 21199863 1 2 1 +DLC1 DLC1 GAP; GAP, Rac/Rho; Tumor suppressor Q96QB1 10395 8p22 human S946-p 37038502 SVSPCPSsPKQIHLD activity, induced; intracellular localization; protein conformation carcinogenesis, inhibited; cell growth, inhibited; cell motility, inhibited talin 1(INDUCES); tensin 1 iso1(INDUCES) 25452387 1 1 0 localize to focal adhesions; activates Rho-GAP activity +Kif3a KIF3A Microtubule-binding; Motor P28741 16568 11 B1.3|11 31.97 cM mouse S698-p 50247605 KPETVIDsLLQ____ activity, induced; molecular association, regulation CDH2(INDUCES) 26335646 1 1 0 enhances N-cadhedrin transport and affects synapse formation +Trim25 TRIM25 EC 6.3.2.19; EC 6.3.2.n3; Ligase; Nuclear receptor co-regulator; Transcription factor; UBIQUITIN LIGASE; Ubiquitin conjugating system; Ubiquitin ligase Q61510 217069 11|11 C mouse S12-p 1868624700 NPLAEELsCSVCLEL protein stabilization carcinogenesis, inhibited 32576271 2 0 0 +HTT Huntingtin Cytoskeletal P42858 3064 4p16.3 human S16-p 12056100 KAFESLKsFQQQQQQ receptor internalization, induced; molecular association, regulation; intracellular localization; protein conformation apoptosis, inhibited; cytoskeletal reorganization HMGB1(INDUCES); Huntingtin(INDUCES); Huntingtin(DISRUPTS); Exportin-1(DISRUPTS) 21623356; 23297360; 24334607; 24505464; 28698602; 30185623; 30538129; 33256402 18 2 0 +Kdr VEGFR2 EC 2.7.10.1; KINASE; Kinase, protein; Membrane protein, integral; Protein kinase, TK; Protein kinase, tyrosine (receptor) P35918 16542 5 C3.3|5 40.23 cM mouse S1191-p 18755301 MEEDSGLsLPTSPVS protein degradation; molecular association, regulation; ubiquitination BTRC(INDUCES) 21402774 1 0 0 +ARRB2 ARRB2 Adaptor/scaffold P32121 409 17p13.2 human Y250-p 1883582902 CLFSTAQyKCPVAQL Arrestin_C activity, induced; molecular association, regulation; protein conformation carcinogenesis, induced RKHD4(INDUCES); IGF1R(INDUCES) 37521868 1 0 0 +RAB1A RAB1A G protein; G protein, monomeric; G protein, monomeric, Rab P62820 5861 2p14 human T75-p 1247157 AGQERFRtITSSYYR Ras activity, induced; molecular association, regulation; intracellular localization GDI1(DISRUPTS) 27482120 1 10 20 membrane localization, ER to Golgi vesicle transport and in maintaining proper Golgi structure +Kcnd2 Kv4.2 Channel, potassium; Membrane protein, integral; Membrane protein, multi-pass Q63881 rat K437-sm 1879723000 LARIRAAkSGSANAY intracellular localization 31213982 2 0 0 increase in Kv4.2 surface expression +Cad CAD Amino Acid Metabolism - alanine, aspartate and glutamate; EC 2.1.3.2; EC 3.5.2.3; EC 6.3.5.5; Hydrolase; KINASE; Ligase; Nucleotide Metabolism - pyrimidine; Transferase B2RQC6 69719 5|5 B1 mouse S1406-p 451249 GAGGRRLsSFVTKGY MGS carcinogenesis, induced; cell motility, induced; cell growth, induced; apoptosis, inhibited 36122209 4 35 5 +GYS1 GYS1 Carbohydrate Metabolism - starch and sucrose; EC 2.4.1.11; Transferase P13807 2997 19q13.33 human S657-p 449790 RHSSPHQsEDEEDPR Glycogen_syn activity, inhibited 22510711 14 31 20 +NTRK2 TrkB EC 2.7.10.1; KINASE; Kinase, protein; Membrane protein, integral; Protein kinase, TK; Protein kinase, tyrosine (receptor) Q16620 4915 9q21.33 human Y707-p 448812 DVYSTDYyRVGGHTM PK_Tyr_Ser-Thr molecular association, regulation signaling pathway regulation PTP1B(INDUCES) 25288805 13 0 28 +MCM3 MCM3 DNA replication; EC 3.6.4.12 P25205 4172 6p12.2 human K230-ub 58948909 DDLVDKAkPGDRVQV MCM_OB cell cycle regulation 27621311 1 1 0 KEAP1-MCM3 associates with chromatin in a cell cycle-dependent manner +Ccdc141 CCDC141 Unknown function E9Q8Q6 545428 2|2 C3 mouse T91-p 1874043200 LLREADRtAEANKAQ protein degradation cell motility, induced 34298015 1 0 0 +Nde1 NUDE1 Cell cycle regulation; Cytoskeletal; Microtubule-binding Q9CZA6 67203 16|16 A1 mouse Y90-p 912008302 EMQHSEGyRQISALE molecular association, regulation PAFAH1B1(DISRUPTS) 29562183 1 1 0 +PRKN PARK2 EC 6.3.2.-; EC 6.3.2.19; Ligase; Translation; Translation regulation; UBIQUITIN LIGASE; Ubiquitin conjugating system; Ubiquitin ligase O60260 5071 6q26 human S65-p 25538008 NCDLDQQsIVHIVQR ubiquitin protein degradation; molecular association, regulation; ubiquitination; intracellular localization; protein conformation; enzymatic activity, induced carcinogenesis, inhibited; autophagy, induced; cell growth, inhibited; autophagy, inhibited ubiquitin(INDUCES); PARK2(INDUCES) 22724072; 23256036; 23754282; 23953109; 24660806; 24671417; 24751536; 24784582; 25375667; 25474007; 26161729; 26254305; 26631732; 31112535; 33730565; 34166935; 36480196 34 10 0 induces mitophagy; induced mitophagy; S65A mutation inhibits PARK2 mitochondrial translocation; PINK1-mediated activation via phosphorylation of of PARK2 at S65 ; induces FAT10ylation of itself and mitofusin2 thus inducing their ubiquitylation and degradation; interaction between the R1 domain and the UBL domain, localized to mitochondria; phosphorylation of PARK2 disrupts the Ubl RING1 interaction, p-ubiquitin S65 binds to a patch on PARK2 RING1 domain +Alyref2 Refbp2 DNA-binding; RNA-binding Q9JJW6 56009 1|1 H3 mouse R188-m2 13906408 RGSQGRGrGTGRNSK FoP_duplication molecular association, regulation RNA(DISRUPTS) 20129943 1 1 0 +SOD2 SOD2 EC 1.15.1.1; Mitochondrial; Oxidoreductase P04179 6648 6q25.3 human K122-me 1872904400 GELLEAIkRDFGSFD Sod_Fe_C cell cycle regulation 22710435 1 1 0 quiescent fibroblasts are dimethylated at K122, and R197 and are also dimethylated in proliferating cells +IQCB1 IQCB1 Cell development/differentiation Q15051 9657 3q13.33|3q21.1 human K19-ub 95155302 SIAAEVAkSPEQNVP intracellular localization cell cycle regulation; cytoskeletal reorganization 28498859 1 3 0 regulation of cilia formation +KIF22 KIF22 Microtubule-binding; Motor Q14807 3835 16p11.2 human T134-p 30993022 GPTGAGKtHTMLGSP Kinesin intracellular localization 35730929 1 2 0 +CYCS CYCS Apoptosis; Mitochondrial; Oxidoreductase; PHOSPHATASE; Protein phosphatase, Ser/Thr (non-receptor) P99999 54205 7p15.3 human Y98-p 469603 ERADLIAyLKKATNE Cytochrom_C protein degradation; molecular association, regulation; enzymatic activity, induced apoptosis, inhibited COX1(INDUCES); HIGD1A(DISRUPTS) 21706253; 30018060 2 8 73 regulates electron donating rate of CYCS, induces activity of COX1, decreases ROS production inducing neuronal survival under ischemia damage +Ppara PPAR-alpha DNA-binding; Nuclear receptor; UBIQUITIN LIGASE P37230 25747 7q34 rat S110-p 457547 RICGDKAsGYHYGVH zf-C4 activity, induced transcription, altered 16042408 1 0 0 +Pparg PPAR-gamma iso2 DNA-binding; Nuclear receptor; Transcription factor P37238-2 19016 6 E3|6 53.41 cM mouse K432-ub 40190210 ESSQLFAkVLQKMTD Hormone_recep protein degradation transcription, inhibited 24072712 1 0 0 +UBA2 SAE2 EC 6.3.2.-; EC 6.3.2.19; Ligase; Motility/polarity/chemotaxis; SUMO LIGASE; SUMO conjugating system; SUMO ligase; UBIQUITIN LIGASE; Ubiquitin conjugating system; Ubiquitin ligase Q9UBT2 10054 19q13.11 human K617-sm 27851105 RKRKLDEkENLSAKR UBA2_C intracellular localization 23095757 1 2 0 nuclear localization +KNL1 CASC5 Cancer Testis Antigen (CTA); Cell cycle regulation Q8NG31 57082 15q15.1 human S60-p 459643 KKNSRRVsFADTIKV phosphorylation cell cycle regulation 25402682 3 31 6 +GIT1 GIT1 GAP; GAP, ARF; Motility/polarity/chemotaxis Q9Y2X7 28964 17q11.2 human S46-p 25784901 RSLGRHIsIVKHLRH ArfGap intracellular localization cell motility, induced; cell adhesion, induced 22893698 1 1 0 +RACK1 RACK1 Adaptor/scaffold; G protein; G protein, heterotrimeric; G protein, heterotrimeric beta; Motility/polarity/chemotaxis; Nuclear receptor co-regulator P63244 10399 5q35.3 human K172-ub 12337352 IVSCGWDkLVKVWNL WD40 protein degradation carcinogenesis, induced 33323973 1 6 17 +Ctnnd2 CTNND2 Actin-binding; Motility/polarity/chemotaxis O35927 18163 15|15 B2 mouse Y1073-p 31014801 ERDRQRPySSSRTPS protein stabilization; molecular association, regulation GSK3B(DISRUPTS) 24412473 1 0 0 increased ability of CTNND2 to enhance the nuclear distribution of B-catenin via E-cadherin +Cdk16 CDK16 Cell cycle regulation; EC 2.7.11.22; KINASE; Kinase, protein; Motility/polarity/chemotaxis; Protein kinase, CMGC; Protein kinase, Ser/Thr (non-receptor) Q04735 18555 X A1.3|X 16.18 cM mouse S78-p 4272751 HEDMKMGsDGESDQA molecular association, regulation CCNYL1(DISRUPTS) 26305884 2 17 1 +SCYL1 SCYL1 KINASE; Kinase, protein; Protein kinase, Other; Protein kinase, Ser/Thr (non-receptor) Q96KG9 57410 11q13.1 human T469-p 33402213 STRHRVLtSAFSRAT intracellular localization carcinogenesis, induced; carcinogenesis, altered 24769208 1 0 0 1) Increase in centrosomal loading of SCYL1 leads to displacement of C-NAP1. 2) Increased centrosomal expression of SCYL1 lead to centrosome splitting and amplification. +ACP1 ACP1 Cofactor and Vitamin Metabolism - riboflavin; EC 3.1.3.2; EC 3.1.3.48; Motility/polarity/chemotaxis; PHOSPHATASE; Phosphatase (non-protein); Protein phosphatase, tyrosine (non-receptor) Q3SZ94 280977 cow Y132-p 450718 QLIIEDPyYGNDADF LMWPc enzymatic activity, induced 10452533 5 15 194 +FZR1 FZR1 UBIQUITIN LIGASE; Ubiquitin conjugating system Q9UM11 51343 19p13.3 human S36-p 3215928 RTLTPASsPVSSPSK protein stabilization 30498084 1 14 2 AURKA stabilization +Hspb6 HSP20 Chaperone; Heat shock protein P97541 192245 1q21 rat S16-p 450706 PSWLRRAsAPLPGFS Crystallin molecular association, regulation apoptosis, inhibited; cytoskeletal reorganization PDE4D(INDUCES) 12663991; 15105294; 21334344 21 31 2 +Fli1 FLI1 DNA-binding; Oncoprotein; Transcription factor P26323 14247 9 A4|9 17.74 cM mouse T312-p 6406002 TNGEFKMtDPDEVAR Ets protein degradation transcription, inhibited 25707716 6 0 0 inhibited transcription of CDH5, PECAM1, PDGFB and MMP9 genes, impaired leaky vessels +MYO6 MYO6 Actin-binding; Motility/polarity/chemotaxis; Motor Q29122 397085 pig T406-p 449089 TAGGAKGtVIKVPLK Myosin_head cytoskeletal reorganization 16917816 4 14 1 T406E mutant clusters vesicles and alters F-actin (increase of filaments and bundled). Motor moves laterally in cell instead of inward. No change in velocity. +UBA52-RPS27A-UBB-UBC ubiquitin Ubiquitin-like modifier P62988 2p16 human K63-ub 486304 LSDYNIQkESTLHLV ubiquitin receptor internalization, induced; protein degradation; protein stabilization; molecular association, regulation; enzymatic activity, inhibited; phosphorylation; enzymatic activity, induced; activity, induced; ubiquitination; intracellular localization cell cycle regulation; carcinogenesis, induced; cell motility, induced; cell adhesion, induced; cell motility, inhibited; signaling pathway regulation; cell growth, induced; DNA repair, inhibited; transcription, inhibited; cell growth, altered; carcinogenesis, inhibited; cell growth, inhibited; transcription, induced; transcription, altered; DNA repair, induced; endocytosis, induced; autophagy, induced; cell differentiation, induced; apoptosis, inhibited CTNNB1(DISRUPTS); Cezanne(INDUCES); TAK1(INDUCES); NPL4(DISRUPTS); LATS1(DISRUPTS); IKKG(INDUCES); TRIM21(INDUCES); CALCOCO2(INDUCES); LC3A(DISRUPTS); PYGO1(DISRUPTS); TAB2(INDUCES); TRAF2(INDUCES); UBL4A(INDUCES) DNA(DISRUPTS) 11460167; 18212250; 18326498; 18613717; 19854138; 19854139; 19858201; 19935683; 21102657; 26471729; 28458162; 29378950; 30918126; 30929559; 30931944; 31042464; 31070797; 31073027; 31127032; 31182807; 31269432; 31451677; 31619538; 31902824; 31937588; 31999304; 32051553; 32453758; 32679077; 33067265; 33196940; 33710666; 35064336; 35100065; 35110531; 35316220; 35503863; 35792897; 35853811; 35856559; 35864951; 35918322; 35938958; 36088509; 36115849; 36289618; 36473924; 37027301; 37330913; 37450367 121 39 155 K139 ubiquitylation promotes cell proliferation and motility-migration and metastasis; GPR108 interacts with Smurf1, followed by the recruitment of IRF3 during viral infection; TRIM21 affected the expression of the target genes of NF-kB R but not in PPDPF knockdown cells ; GPR108 and Smurf1 mediated degradation requires NDP52; K139 is critical for its binding to TRAF2 and activation of the NF-kB pathways leading to proliferation and migration; NDP52-dependent autophagic degradation of phosphorylated IRF3; autoamplifcation of NFAT-c1, which promotes osteoclast differentiation, suppressed by MLN4924; formation of CPC complex, required for proper mitotic progression, critical site for cell survival +Cry2 CRY2 DNA-binding; Lyase Q9R194 12953 2|2 E1 mouse K503-ub 27717312 RLNIERMkQIYQQLS FAD_binding_7 protein degradation; intracellular localization 23452856 1 3 0 +Syn1 SYN1 Vesicle P09951 24949 Xq11 rat S67-p 451573 VASPAAPsPGSSGGG neural plasticity 33519375; 35723394 16 11 1 +SCN5A SCN5A Channel, sodium; Membrane protein, integral; Membrane protein, multi-pass Q14524 6331 3p22.2 human S667-p 25752820 QRALSAVsVLTSALE Na_trans_cytopl activity, induced; protein conformation 33410863 3 5 1 +Trpm7 ChaK1 Channel, cation; EC 2.7.11.1; KINASE; Kinase, protein; Membrane protein, integral; Membrane protein, multi-pass; Protein kinase, Ser/Thr (non-receptor); Protein kinase, atypical Q923J1 58800 2|2 F1 mouse D1510-ca 57858700 TEDSPEVdSKAALLP activity, induced apoptosis, induced 22698280 1 0 0 increase channel current +Clcn3 CLCN3 iso2 Channel, chloride; Membrane protein, integral; Membrane protein, multi-pass; Transporter; Transporter, ion channel; Vesicle P51792-2 84360 rat T532-p 51381106 LGGVTRMtVSLVVIV Voltage_CLC cell motility, induced 26562480 1 0 0 AngII-induced Cl- current and VSMC migration, AngII-induced hypertensive vascular remodeling +HK1 HK1 Carbohydrate Metabolism - amino sugar and nucleotide sugar; Carbohydrate Metabolism - fructose and mannose; Carbohydrate Metabolism - galactose; Carbohydrate Metabolism - glycolysis and gluconeogenesis; Carbohydrate Metabolism - starch and sucrose; EC 2.7.1.1; Kinase, other; Mitochondrial P19367 3098 10q22.1 human S124-p 55569800 NIVHGSGsQLFDHVA Hexokinase_1 enzymatic activity, induced 27153534 1 1 0 +CDCP1 CDCP1 Cell surface; Membrane protein, integral Q9H5V8 64866 3p21.31 human Y762-p 455577 LQPEVDTyRPFQGTM molecular association, regulation cell growth, induced PKCD(INDUCES) 15851033; 23300860 3 1 2 +CELF1 CELF1 Cell development/differentiation; RNA processing; RNA-binding Q92879 10658 11p11.2 human S300-p 29668005 VLTSSGSsPSSSSSN RNA splicing, altered 24151077 1 1 0 splicing regulation in diabetes +CASP6 CASP6 Apoptosis; EC 3.4.22.59; Protease P55212 839 4q25 human C277-pa 60885601 IGKKQVPcFASMLTK Peptidase_C14 molecular association, regulation; enzymatic activity, inhibited; protein conformation 27911442 1 0 0 Palmitoylation inhibits CASP6 activity by blocking substrate binding site and dimerization. +HDAC2 HDAC2 DEACETYLASE; Deacetylase; EC 3.5.1.98; Nuclear receptor co-regulator; Transcription, coactivator/corepressor Q92769 3066 6q21 human S424-p 467980 CDEEFSDsEDEGEGG acetylation; molecular association, regulation; enzymatic activity, inhibited p53(INDUCES); HDAC1(INDUCES); KLF4(DISRUPTS) 19486889; 20388487 4 73 49 +Cs CS Carbohydrate Metabolism - citrate (TCA) cycle; Carbohydrate Metabolism - glyoxylate and dicarboxylate; EC 2.3.3.1; Mitochondrial; Transferase Q9CZU6 12974 10|10 D3 mouse S225-p 4774521 RNLYREGsSIGAIDS Citrate_synt enzymatic activity, inhibited 31628154 1 3 2 +Kcnd2 Kv4.2 Channel, potassium; Membrane protein, integral; Membrane protein, multi-pass Q9Z0V2 16508 6 A2-A3.1|6 8.49 cM mouse S552-p 450462 VSGSHRGsVQELSTI activity, induced 31311860 6 8 0 +CCNO CCNO Cell cycle regulation; DNA repair, damage; EC 3.2.2.-; Hydrolase P22674 10309 5q11.2 human S81-p 7445148 PSAARGGsPLPGPAQ enzymatic activity, induced 25364462 1 11 0 stimulates CDK2 kinase activity +HNRNPA1 hnRNP A1 Nuclear export; RNA splicing; RNA-binding; Spliceosome P09651 3178 12q13.13 human S199-p 451555 SQRGRSGsGNFGGGR molecular association, regulation; activity, inhibited cell cycle regulation; carcinogenesis, inhibited; cell differentiation, induced; cell growth, inhibited; translation, inhibited CHIP(INDUCES); FOXP3(INDUCES) 18562319; 21454539; 34080184 6 9 8 +RCJMB04_5k17 CARD11 Adaptor/scaffold Q5F3W0 416476 chicken S578-p 457640 NRNDSIMsTTPEPPG activity, induced; molecular association, regulation Bcl-10(INDUCES); MALT1(INDUCES) 18086859; 24833394 5 0 0 switchlike activation of NF-kB +MYC Myc DNA-binding; Nucleolus; Oncoprotein; Transcription factor P01106 4609 8q24.21 human S362-p 466010 RKCTSPRsSDTEENV carcinogenesis, inhibited; transcription, inhibited 24030976 3 1 0 +MFF MFF Membrane protein, integral; Mitochondrial Q9GZY8 56947 2q36.3 human S172-p 484865 GQLVRNDsLWHRSDS Miff ubiquitination cell cycle regulation; carcinogenesis, inhibited; autophagy, induced; cell growth, inhibited; cell growth, induced 34010649; 36481655 6 54 13 +PLK2 PLK2 EC 2.7.11.21; KINASE; Kinase, protein; Protein kinase, Other; Protein kinase, Ser/Thr (non-receptor); Tumor suppressor Q9NYY3 10769 5q11.2 human S358-p 1883594400 VPDFHLSsPAKNFFK protein stabilization; phosphorylation; enzymatic activity, induced carcinogenesis, induced; cell motility, induced; cell growth, induced 37387444 1 0 0 induces SNCA phosphorylation +NRL NRL DNA-binding; Transcription factor P54845 4901 14q11.2-q12 human S117-p 1880112600 PHGYYPGsPEETGAQ transcription, inhibited 36226585 1 0 0 +RFX1 RFX1 DNA-binding P22670 5989 19p13.12 human S120-p 452650 SETVSEAsPGSTASQ transcription, inhibited 26041775 1 3 0 +STK26 MST4 EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, STE; Protein kinase, Ser/Thr (non-receptor) Q9P289 51765 Xq26.2 human T327-p 4270933 THPEWSFtTVRKKPD molecular association, regulation carcinogenesis, induced; cell motility, induced MOB1A(INDUCES) 30072378 1 4 8 +EIF4EBP1 4E-BP1 Translation; Translation initiation Q13541 1978 8p11.23 human T50-p 3195728 FSTTPGGtRIIYDRK eIF_4EBP phosphorylation cell growth, induced; translation, induced EIF4E(DISRUPTS) 23584478; 24247720 2 20 38 T41 and T50 act as priming sites for T37/46; T41A and T50A mutants inhibited tumor growth and showed more cap-binding. +MAF MAF Cell development/differentiation; DNA-binding; Oncoprotein; Transcription factor; Tumor suppressor O75444 4094 16q23.2 human S15-p 487502 SNSDLPTsPLAMEYV transcription, altered 17897790 1 0 0 sites behave in a dramatic cell type-specific manner +Pygl PYGL Carbohydrate Metabolism - starch and sucrose; EC 2.4.1.1; Transferase Q9ET01 110095 12 C2|12 29.01 cM mouse K796-ac 23003809 SQLYMNQkAWNTMVL Phosphorylase enzymatic activity, inhibited; phosphorylation PPP1CA(INDUCES) 22225877 1 0 0 acetylation enhances its interaction with the PPP1CA substrate-targeting PL, promoting PYGL dephosphorylation +Cftr CFTR Channel, chloride; EC 3.6.3.49; Hydrolase; Membrane protein, integral; Membrane protein, multi-pass; Transporter; Transporter, ABC family P26361 12638 6 A2|6 8.1 cM mouse T1467-p 21440502 ITALKEEtEEEVQET protein degradation 24058532 2 1 0 protein destabilization +SIRT1 SIRT1 Apoptosis; DEACETYLASE; Deacetylase; EC 3.5.1.-; Nuclear receptor co-regulator Q96EB6 23411 10q21.3 human S27-p 452898 ADREAASsPAGEPLR activity, induced; acetylation; protein stabilization; ubiquitination; intracellular localization; enzymatic activity, induced carcinogenesis, induced; cell motility, induced; cell growth, induced; transcription, induced; signaling pathway regulation 20027304; 23754392; 34826187 5 19 1 inhibits ubiquitination of itself, induces deacetylation of Snail to increase the production of IL-6/IL8; expression and regulation of SIRT1 target antioxidative and anti-inflammatory genes increased +HMGB1 HMGB1 DNA repair, damage; Nuclear receptor co-regulator P09429 3146 13q12.3 human S35-p 476055 KKKHPDAsVNFSEFS HMG_box_2 intracellular localization cell motility, altered 19506549; 23782844 3 23 3 increases tumor cell invasiveness +HSPA5 GRP78 Chaperone; Heat shock protein; KINASE P11021 3309 9q33.3 human T69-p 55370298 TPSYVAFtPEGERLI HSP70 protein stabilization; molecular association, regulation carcinogenesis, induced; cell growth, induced; apoptosis, inhibited TRIM21(DISRUPTS) 36042349 1 2 0 inhibits ubiquitination +Traf6 TRAF6 EC 6.3.2.-; Ligase; UBIQUITIN LIGASE; Ubiquitin conjugating system; Ubiquitin ligase P70196 22034 2|2 E2 mouse T494-p 34362608 LEALRQGtFIKDDTL ubiquitination; protein conformation transcription, inhibited 25642822 1 0 1 prevent its oligomerization and autoubiquitination, inhibits LPS-stimulated transcription of Tnf and Il6 +AKT1 Akt1 EC 2.7.11.1; KINASE; Kinase, protein; Oncoprotein; Protein kinase, AGC; Protein kinase, Ser/Thr (non-receptor) P31749 207 14q32.33 human K142-m3 1879848301 EVSLAKPkHRVTMNE enzymatic activity, induced carcinogenesis, induced; cell motility, induced JMJD2B(INDUCES); JMJD2A(INDUCES); PDK1(INDUCES); TRAF6(INDUCES) 30692625 1 1 0 interaction of Akt1 with TRAF6, and subsequent Akt ubiquitination ; promotes cell growth and glycolysis +Crkl CRKL Adaptor/scaffold; Motility/polarity/chemotaxis P47941 12929 16|16 A3 mouse Y207-p 447954 IPEPAHAyAQPQTTT carcinogenesis, induced; cell growth, induced; apoptosis, inhibited; signaling pathway regulation 22169110 15 20 1215 RAF-MEK-ERK pathway +WWTR1 TAZ Oncoprotein; Transcription, coactivator/corepressor Q9GZV5 25937 3q25.1 human S93-p 3211887 RSHSSPAsLQLGTGA molecular association, regulation; intracellular localization 14-3-3 beta(DISRUPTS) 33086783 1 7 9 +IKBKG IKKG Adaptor/scaffold; Protein kinase, regulatory subunit Q9Y6K9 8517 Xq28 human S377-p 3217806 PAPAYLSsPLALPSQ enzymatic activity, inhibited; phosphorylation signaling pathway regulation 23131831 1 5 53 modulates IFKB phosphorylation; regulation of TCR mediated calcium (Ca2+) influx; NF-kB pathway +RXRA RXRA DNA-binding; Motility/polarity/chemotaxis; Nuclear receptor P19793 6256 9q34.2 human S32-p 456811 RGSMAAPsLHPSLGP Nuc_recep-AF1 molecular association, regulation; activity, inhibited transcription, inhibited SRC-1(DISRUPTS) 16184197; 20432439 2 0 0 +ECT2 ECT2 GEF; GEF, Rac/Rho; Motility/polarity/chemotaxis Q9H8V3 1894 3q26.31 human T444-p 457522 TKSSKSStPVPSKQS activity, induced; molecular association, regulation transcription, altered PLK1(INDUCES) 16247472 2 3 11 phosphorylation important for RhoA activation +FANCD2 FANCD2 DNA repair, damage Q9BXW9 2177 3p25.3 human T896-p 27448950 KNSECDPtPSHRGQL FancD2 molecular association, regulation; ubiquitination; intracellular localization; activity, inhibited cell cycle regulation; DNA repair, inhibited; signaling pathway regulation DNA(DISRUPTS) 31167143 1 4 0 inhibits Fanconi anemia pathway leading to inhibition of DNA repair; 882-898 cluster +RPS10 RPS10 Nucleolus; RNA-binding; Ribosomal; Translation P46783 6204 6p21.31 human R160-me 13906403 RGGFGRGrGQPPQ__ protein stabilization; molecular association, regulation; intracellular localization NPM1(INDUCES) 20159986 1 0 0 localization in the granular component (GC) region of the nucleolus; efficient assembly of RPS10 into ribosomes and protein synthesis +Lrrk2 LRRK2 EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, Ser/Thr (non-receptor); Protein kinase, TKL Q5S006 66725 15|15 E3 mouse S973-p 4725913 SHMRQSDsSSSLASE enzymatic activity, inhibited autophagy, induced 37454104 14 13 0 +NCF1 p47phox EC 1.-.-.-; Oxidoreductase P14598 653361 7q11.23 human S304-p 449406 GAPPRRSsIRNAHSI NECFESHC activity, induced; molecular association, regulation; intracellular localization; enzymatic activity, induced cell growth, induced; signaling pathway regulation CYBA(INDUCES) 10559253; 12056906; 20920494; 31736979; 33139577; 35108370 17 0 0 induces ROS production; LPS-induced activation of p38MAPK and ERK1/2 signaling pathways +MAP4K1 HPK1 EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, STE; Protein kinase, Ser/Thr (non-receptor) Q92918 11184 19q13.2 human T175-p 4198300 RRLSFIGtPYWMAPE Pkinase protein degradation; enzymatic activity, induced transcription, altered 15743830; 24362026 2 1 3 +AQP1 AQP1 Membrane protein, integral; Membrane protein, multi-pass; Transporter; Transporter, aquaporin family P29972 358 7p14.3 human T239-p 482807 APRSSDLtDRVKVWT activity, induced; intracellular localization 17522053; 22334691 2 0 0 T157A/T239A double mutation inhibits AQP1 translocation to the plasma membrane following hypotonic exposure; phosphorylation by PKC increases ion currents and water permability of AQP1. +NOTCH1 Notch 1 Membrane protein, integral; Motility/polarity/chemotaxis; Oncoprotein; Receptor, misc.; Transcription factor P46531 4851 9q34.3 human T1897-p 20831303 CSGGGLEtGNSEEEE molecular association, regulation; activity, inhibited transcription, induced; transcription, inhibited RBPJ(INDUCES) DNA(DISRUPTS) 21685388; 24220241 2 0 0 +NFKB1 NFkB-p105 DNA-binding; Transcription factor P19838 4790 4q24 human S328-p 22771100 INITKPAsVFVQLRR RHD_dimer molecular association, regulation transcription, inhibited DNA(DISRUPTS) 22152481; 23180782 4 1 0 +FOXO1 FOXO1A DNA-binding; Nuclear receptor co-regulator; Oncoprotein; Transcription factor Q12778 2308 13q14.11 human S418-p 478369 NTSLNSPsPNYQKYT intracellular localization transcription, altered 20061393 4 1 0 multiple site mutant (8A) +KCNK9 KCNK9 Membrane protein, integral; Membrane protein, multi-pass Q9NPC2 51305 8q24.3 human S373-p 18609100 RLMKRRKsV______ activity, induced; intracellular localization 21357689 1 0 0 +XIAP XIAP Apoptosis; EC 6.3.2.-; Ligase; UBIQUITIN LIGASE; Ubiquitin conjugating system; Ubiquitin ligase P98170 331 Xq25 human K322-ub 22547401 DPWEQHAkWYPGCKY BIR protein degradation 22072751 1 1 0 +CSF3R GCSFR Membrane protein, integral; Receptor, cytokine Q99062 1441 1p34.3 human K704-ub 9381806 TVLEEDEkKPVPWES receptor internalization, induced; protein degradation; intracellular localization; phosphorylation carcinogenesis, inhibited; cell growth, inhibited; signaling pathway regulation 19453968; 28439110 2 0 0 regulates production of neutrophilic granulocytes, regulates STAT5 activation; inhibited STAT5 activation +SPRY1 SPRY1 Adaptor/scaffold; Inhibitor; Motility/polarity/chemotaxis O43609 10252 4q28.1 human Y53-p 454589 AIRGSNEyTEGPSVV molecular association, regulation; phosphorylation carcinogenesis, inhibited; signaling pathway regulation GRB2(INDUCES) 32188694 3 18 234 inhibits Ras-mediated ERK1/2 and AKT phosphorylation and pathways +Jun Jun Oncoprotein; Transcription factor P17325 24516 5q33 rat S63-p 447686 KNSDLLTsPDVGLLK Jun activity, induced; protein stabilization transcription, altered; cell growth, altered 12169099; 1749429 133 43 4 +SOD1 SOD1 Apoptosis; EC 1.15.1.1; Mitochondrial; Nuclear receptor co-regulator; Oxidoreductase P00441 6647 21q22.11 human K123-ac 11317132 RTLVVHEkADDLGKG Sod_Cu intracellular localization 28739857 2 8 2 mitochondrial localization, inihibits SOD1-mediated suppression of mitochondrial respiration +Irf4 IRF4 DNA-binding; Oncoprotein; Transcription factor Q64287 16364 13|13 A3.2 mouse S447-p 12265165 HRSLRHSsIQE____ cell differentiation, induced; transcription, induced DNA(INDUCES) 20697158 1 1 0 production of IL-17 and IL-21 +LRRK1 LRRK1 EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, Ser/Thr (non-receptor); Protein kinase, TKL Q38SD2 79705 15q26.3 human S1064-p 15411924 NRKVTIYsFTGNQRN phosphorylation; enzymatic activity, induced 36040231 1 1 1 induces Rab7 phosphorylation +DVL3 DVL3 Motility/polarity/chemotaxis Q92997 1857 3q27.1 human S697-p 4729017 VPPELTAsRQSFRMA Dsh_C intracellular localization 27486244 2 4 0 centrosomal signal for pS697 accumulated throughout the cell cycle, pS280 only in mitotic spindle and not in the interphase centrosome +TP63 p63 iso2 DNA-binding; Transcription factor Q9H3D4-2 8626 3q28 human S368-p 34504455 SPSSYGNsSPPLNKM molecular association, regulation DNA(INDUCES) 34761935 0 2 0 +FBXW7 FBXW7 Motility/polarity/chemotaxis; Nucleolus; UBIQUITIN LIGASE; Ubiquitin conjugating system; Ubiquitin ligase Q969H0 55294 4q31.3 human S227-p 17792400 QQRRRITsVQPPTGL protein degradation; protein stabilization; ubiquitination apoptosis, induced; transcription, altered 21620836 2 0 0 +Nrip1 RIP140 Nuclear receptor co-regulator; Transcription, coactivator/corepressor Q8CBD1 268903 16|16 C3.1 mouse K778-me 6742803 LPLNHDAkSAPFLGV NRIP1_repr_3 molecular association, regulation; methylation transcription, inhibited HDAC3(INDUCES) 19216533 1 1 0 inhibits arginine methylation +YAP1 YAP1 Oncoprotein; Transcription, coactivator/corepressor P46937 10413 11q22.1 human K321-ub 603486522 EKERLRLkQQELLRQ activity, induced; protein degradation; ubiquitination; intracellular localization carcinogenesis, inhibited; apoptosis, induced; cell motility, inhibited 29891922; 33939216; 36280829 3 2 0 +BECN1 beclin 1 Adaptor/scaffold; Autophagy; Membrane protein, peripheral Q14457 8678 17q21.31 human S90-p 472001 IPPARMMsTESANSF molecular association, regulation; ubiquitination carcinogenesis, induced; carcinogenesis, inhibited; autophagy, induced; cell differentiation, induced; cell growth, inhibited; apoptosis, induced; signaling pathway regulation Bcl-2(DISRUPTS); SLC7A11(INDUCES); PIK3C3(NOT_REPORTED) 23878393; 25693418; 26994142; 29079782; 30057310; 31220095; 31696776; 32187724; 34851698 10 4 10 +KRT20 K20 Cytoskeletal P35900 54474 17q21.2 human S13-p 463823 RSFHRSLsSSLQAPV apoptosis, induced 16608857 3 7 0 promotes keratin filaments disassembly +Tlr4 TLR4 Membrane protein, integral; Receptor, misc. Q9QUK6 21898 4 C1|4 34.66 cM mouse Y672-p 478360 YSRGESIyDAFVIYS TIR phosphorylation transcription, induced; signaling pathway regulation 37058370 3 1 0 +INPP5D SHIP iso2 EC 3.1.3.86; Motility/polarity/chemotaxis; Phosphatase, lipid Q92835-2 3635 2q37.1 human S933-p 4778416 LHVKQTLsPDQQPTA intracellular localization 29852247 2 9 0 nucleocytoplasmic shuttling (A mutant reduced accumulation in nucleus) +EPHB2 EphB2 EC 2.7.10.1; KINASE; Kinase, protein; Membrane protein, integral; Protein kinase, TK; Protein kinase, tyrosine (receptor); Tumor suppressor P29323 2048 1p36.12 human K891-ub 1881446405 IRNPNSLkAMAPLSS molecular association, regulation autophagy, induced MAP1LC3B2(INDUCES) 33280498 1 1 0 +Gapvd1 GAPVD1 GAP; GAP, Ras; GEF; GEF, Rab; Vesicle Q6PAR5 66691 2|2 B mouse S902-p 468085 ERLVRSRsSDIVSSV endocytosis, inhibited 30772465 1 67 87 phosphorylation of this site reduces endocytosis of LDL +Scnn1a ENaC-alpha Channel, sodium; Membrane protein, integral; Membrane protein, multi-pass; Transporter, ion channel P37089 25122 4q42 rat S621-p 454020 RFRSRYWsPGRGARG activity, induced; intracellular localization; phosphorylation 15234985; 21220922; 35525869 4 0 0 primes phosphorylation at S617 +PYGB PYGB Carbohydrate Metabolism - starch and sucrose; EC 2.4.1.1; Kinase, other; Phosphorylase; Transferase P11216 5834 20p11.21 human S15-p 456885 SEKRKQIsVRGLAGL signaling pathway regulation 21668450 4 17 1 regulation of glycogen synthesis via R3F-PP1 signaling in astrocytoma cells +PPP1R12A MYPT1 Motility/polarity/chemotaxis; PHOSPHATASE; Protein phosphatase, regulatory subunit O14974 4659 12q21.2-q21.31 human S589-gl 1868585002 LQKSLLSsTSTTTKI molecular association, regulation; phosphorylation cell cycle regulation PLK1(DISRUPTS) 32295844 1 1 0 inhibits CDK1-dependent phosphorylation at MYPT1 S473, regulates mitotic progression and centrosome integrity +RAC1 RAC1 G protein; G protein, monomeric; G protein, monomeric, Rho; Motility/polarity/chemotaxis P63000 5879 7p22.1 human S71-p 447994 YDRLRPLsYPQTDVF Ras protein degradation; activity, inhibited 10617634; 23512198 6 3 6 Akt induces Rac1 degradation via S71 phosphorylation; Phosphorylation of this site inhibits GTP binding activity of Rac1 without affecting its GTPase activity. +Kcnk2 TREK-1 Channel, potassium; Membrane protein, integral; Membrane protein, multi-pass P97438 16526 1|1 H6 mouse S348-p 456161 KETRRRLsVEIYDKF activity, induced; activity, inhibited cytoskeletal reorganization 10835347; 11319556; 15976821; 16006563; 17916432 8 5 0 +CLIP1 Restin iso3 Cytoskeletal P30622-2 6249 12q24.31 human S195-p 468616 LTKTASEsISNLSEA protein stabilization; intracellular localization cell cycle regulation; carcinogenesis, induced; apoptosis, inhibited; transcription, altered 23661607 2 56 33 induce AR stabilization and nuclear translocation/accumulation +kif2c KIF2C Cancer Testis Antigen (CTA); Microtubule-binding; Motility/polarity/chemotaxis; Motor Q91636 380006 frog S196-p 2132102 NNQGRRKsNIVKEME molecular association, regulation; intracellular localization; protein conformation; activity, inhibited cytoskeletal reorganization TUBB1(DISRUPTS) DNA(DISRUPTS) 17567953; 18434591; 24291095 5 2 25 +DGCR8 DGCR8 Nucleolus; RNA processing; RNA-binding Q8WYQ5 54487 22q11.21 human S677-p 1874101914 RVGKQLAsQKILQLL dsrm protein stabilization; molecular association, regulation; ubiquitination; intracellular localization DNA repair, induced USP51(INDUCES) 34188037 1 1 0 induces deubiquitination of itself and promotes histone ubiquitination +RPS6KB2 P70S6KB EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, AGC; Protein kinase, Ser/Thr (non-receptor); Translation Q9UBS0 6199 11q13.2 human S423-p 455991 SSPRAPVsPLKFSPF enzymatic activity, induced 11108720 2 18 44 +RPS6KA4 MSK2 EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, AGC; Protein kinase, Ser/Thr (non-receptor) O75676 8986 11q13.1 human S343-p 450045 TRLEPVYsPPGSPPP Pkinase_C enzymatic activity, induced 10806207 1 34 5 +Canx Calnexin Calcium-binding; Endoplasmic reticulum; Membrane protein, integral; Motility/polarity/chemotaxis P35564 12330 11 B1.3|11 30.46 cM mouse S563-p 456360 EEDGVTGsQDEEDSK molecular association, regulation; intracellular localization TrkB(DISRUPTS) 37506696 7 85 48 regulates TRKB transport to the cell membrane +PKM PKM Carbohydrate Metabolism - glycolysis and gluconeogenesis; Carbohydrate Metabolism - pyruvate; EC 2.7.1.40; KINASE; Kinase, other; Mitochondrial; Nucleotide Metabolism - purine P14618 5315 15q23 human T405-gl 394791402 LRRLAPItSDPTEAT molecular association, regulation; intracellular localization; protein conformation; phosphorylation cell growth, induced ERK2(INDUCES); ERK1(INDUCES) 29229835 2 1 0 promotes Warburg effect and cell proliferation, tumor growth, disassociation of the PKM2 tetramer ; nuclear translocation +Srf SRF Motility/polarity/chemotaxis; Transcription factor Q9JM73 20807 17|17 C mouse S99-p 447692 RGLKRSLsEMELGVV transcription, induced 21109534 14 3 5 +APP APP Apoptosis; Cell surface; Membrane protein, integral; Receptor, misc.; Transcription factor P05067 351 21q21.3 human K699-ne 12124806 AEDVGSNkGAIIGLM Beta-APP transcription, inhibited Fe65(DISRUPTS) 18096514 1 0 0 +DYRK2 DYRK2 iso2 EC 2.7.12.1; KINASE; Kinase, protein; Protein kinase, CMGC; Protein kinase, dual-specificity (non-receptor) Q92630-2 8445 12q15 human S499-p 1874397822 KLPPPSSsASKLRTN enzymatic activity, induced cell cycle regulation; apoptosis, induced 34363019 1 1 0 +Crmp1 CRMP-1 Cell development/differentiation; Cytoskeletal; Hydrolase P97427 12933 5 B3|5 19.96 cM mouse S524-p 4712824 PSAKSSPsKHQPPPI phosphorylation 29758318 1 5 1 S522A KI mice +YAP1 YAP1 Oncoprotein; Transcription, coactivator/corepressor P46937 10413 11q22.1 human T77-p 126835301 NAVMNPKtANVPQTV molecular association, regulation apoptosis, induced; transcription, altered TEAD1(DISRUPTS); p73(INDUCES) 28171658 2 2 0 P73 transcription induced, TEAD1 inhibited +ARHGEF6 ARHGEF6 GEF; GEF, Rac/Rho; Motility/polarity/chemotaxis Q15052 9459 Xq26.3 human S225-p 456738 KSSERPLsPKAVKGF activity, induced cell motility, induced; cell growth, induced 25694429 1 25 0 GEF +GIT1 GIT1 GAP; GAP, ARF; Motility/polarity/chemotaxis Q9Y2X7 28964 17q11.2 human Y383-p 481671 DLDDQHDyDSVASDE intracellular localization cell motility, altered; cytoskeletal reorganization 20689073 4 12 180 important for podosome formation and PLC gamma activation +UNC5B UNC5B Membrane protein, integral; Receptor, misc. Q8IZJ1 219699 10q22.1 human T428-p 1870414700 FHPVNFKtARPSNPQ apoptosis, induced; transcription, inhibited 32929029 1 0 0 +PPP1R3A PPP1R3A Membrane protein, integral; Protein phosphatase, regulatory subunit Q16821 5506 7q31.1 human S65-p 449321 SSGTRRVsFADSFGF molecular association, regulation PPP1CA(DISRUPTS) 10748124 6 1 0 Association transiently lost after insulin treatment. +HOXA10 HOXA10 DNA-binding; Transcription factor P31260 3206 7p15.2 human T362-p 1880104200 FLFNMYLtRERRLEI protein stabilization transcription, induced; signaling pathway regulation 36216824 1 1 0 induces ITGB3 signaling pathway +Ulk1 ULK1 Autophagy; EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, Other; Protein kinase, Ser/Thr (non-receptor) O70405 22241 5|5 F mouse R170-me 1876620100 IADFGFArYLQSNMM Pkinase phosphorylation carcinogenesis, induced; autophagy, induced; cell growth, induced 35246531 1 1 0 induces autophosphorylation at T180 +TEK TIE2 EC 2.7.10.1; KINASE; Kinase, protein; Membrane protein, integral; Protein kinase, TK; Protein kinase, tyrosine (receptor) Q02763 7010 9p21.2 human Y1102-p 450256 MLEERKTyVNTTLYE molecular association, regulation; enzymatic activity, induced cell adhesion, altered SHC1(NOT_REPORTED) 14665640; 20973951 5 0 0 +AGO2 AGO2 EC 3.1.26.n2; RNA processing; RNA-binding Q9UKV8 27161 8q24.3 human Y393-p 17533102 ASFNTDPyVREFGIM ArgoL2 sumoylation; molecular association, regulation; protein conformation cell cycle regulation; carcinogenesis, induced; cell growth, inhibited; apoptosis, inhibited; RNA stability, altered KRas(DISRUPTS); NRas(DISRUPTS); DICER1(DISRUPTS); HRas(DISRUPTS); TRBP(DISRUPTS) 23636329; 25036361; 25175024; 31981897; 35923912 8 2 0 +USP35 USP35 DEUBIQUITINASE; EC 3.4.19.12; Protease; Ubiquitin conjugating system; Ubiquitin-specific protease Q9P2H5 57558 11q14.1 human S613-p 3214749 CRRRRLGsVMRPTED UCH intracellular localization carcinogenesis, induced; cell growth, induced; transcription, induced 34131114 1 10 0 +MELK MELK EC 2.7.10.2; EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, CAMK; Protein kinase, Ser/Thr (non-receptor); Protein kinase, tyrosine (non-receptor); RNA splicing Q14680 9833 9p13.2 human T478-p 451160 RNQCLKEtPIKIPVN molecular association, regulation translation, altered NIPP-1(INDUCES) 14699119 1 8 4 regulates translation = spliceosome assembly +MYC Myc DNA-binding; Nucleolus; Oncoprotein; Transcription factor P01106 4609 8q24.21 human K158-ac 458891 SGFSAAAkLVSEKLA Myc_N molecular association, regulation ZBTB17(INDUCES) 16126174 2 2 0 induces association with ZBTB17 on specific target promoters +Pard3 PAR3-alpha Adaptor/scaffold; Motility/polarity/chemotaxis Q9Z340 81918 19q12 rat S827-p 467266 REGFGRQsMSEKRTK molecular association, regulation cytoskeletal reorganization PKCZ(DISRUPTS) 12390250 7 11 0 cell polarity +Prkce PKCE EC 2.7.11.13; KINASE; Kinase, protein; Protein kinase, AGC; Protein kinase, Ser/Thr (non-receptor) P16054 18754 17|17 E4 mouse S350-p 486055 RSKSAPTsPCDQELK cell cycle regulation 18604201 2 10 0 +EGFR EGFR EC 2.7.10.1; KINASE; Kinase, protein; Membrane protein, integral; Oncoprotein; Protein kinase, TK; Protein kinase, tyrosine (receptor) P00533 1956 7p11.2 human K929-ub 1065302 EISSILEkGERLPQP PK_Tyr_Ser-Thr receptor recycling, inhibited; protein degradation 16543144; 17940017 2 4 0 +HAUS8 HAUS8 Cell cycle regulation Q9BT25 93323 19p13.11 human S129-p 20609206 TISKKPEsTSFSAPR intracellular localization cell cycle regulation; apoptosis, inhibited 21690413 1 0 0 localization to the spindle +ECT2 ECT2 GEF; GEF, Rac/Rho; Motility/polarity/chemotaxis Q9H8V3 1894 3q26.31 human T359-p 483847 YLYEKANtPELKKSV molecular association, regulation; intracellular localization carcinogenesis, altered; cell growth, altered 21189248 2 18 8 regulates association with PKCI-Par6 complex; activates Rac1 +RBM17 RBM17 RNA splicing; RNA-binding; Spliceosome Q96I25 84991 10p15.1 human T71-p 470694 DDRQIVDtPPHVAAG RNA splicing, induced; cell growth, inhibited; transcription, inhibited; cell adhesion, inhibited 22615491 1 24 5 upregulates EDA inclusion +Nos1 nNOS Amino Acid Metabolism - arginine and proline; EC 1.14.13.39; Oxidoreductase P29476 24598 12q16 rat K131-ac 2459108 QPLGPPTkAVDLSHQ activity, induced 18415985 1 1 0 +LCP2 SLP76 Adaptor/scaffold Q13094 3937 5q35.1 human Y128-p 448219 DGEDDGDyESPNEEE molecular association, regulation; phosphorylation cytoskeletal reorganization; transcription, induced; signaling pathway regulation NCK1(INDUCES); ITK(INDUCES); PIK3R1(INDUCES); VAV1(INDUCES) 11046020; 12817019; 15388330; 17148460; 21725281; 22534133; 22786724; 23901140; 33482200 25 1 0 transcriptional activity of NFAT and AP-1; regulates NK cell activation; regulates TCR signaling +Bad BAD Apoptosis Q61337 12015 19|19 A mouse S128-p 447861 EGMEEELsPFRGRSR Bcl-2_BAD molecular association, regulation apoptosis, induced 14-3-3 zeta(DISRUPTS) 12189144; 15901741 7 10 36 +Ntrk2 TrkB EC 2.7.10.1; KINASE; Kinase, protein; Membrane protein, integral; Protein kinase, TK; Protein kinase, tyrosine (receptor) Q63604 25054 17p14 rat Y705-p 448811 RDVYSTDyYRVGGHT PK_Tyr_Ser-Thr molecular association, regulation; enzymatic activity, induced translation, altered; transcription, altered; signaling pathway regulation PLCG1(INDUCES); SHC1(INDUCES); SH2D1A(INDUCES) 10533983; 16223723; 22563458; 9582017 15 0 49 +DYRK1B DYRK1B EC 2.7.12.1; KINASE; Kinase, protein; Protein kinase, CMGC; Protein kinase, dual-specificity (non-receptor) Q9Y463 9149 19q13.2 human Y273-p 449567 LGQRIYQyIQSRFYR Pkinase enzymatic activity, induced 10910078; 16257974 3 135 3521 +Nfkb1 NFkB-p105 DNA-binding; Transcription factor P25799 18033 3 G3|3 62.82 cM mouse S246-p 1170753400 DSKAPNAsNLKIVRM molecular association, regulation; protein conformation transcription, altered DNA(DISRUPTS) 29873020 1 1 0 +GRB14 GRB14 Adaptor/scaffold Q14449 2888 2q24.3 human S372-p 7611001 ISPMRSIsENSLVAM BPS molecular association, regulation cell cycle regulation; cell growth, altered INSR(INDUCES) 19359342 1 13 0 modulates the Grb14 inhibitory effect on insulin signaling +SYT6 SYT6 Membrane protein, integral; Vesicle Q5T7P8 148281 1p13.2 human T283-p 456501 DRKCKLQtRVHRKTL C2 activity, induced 16111671 1 0 0 +PLSCR1 PLSCR1 Calcium-binding; Membrane protein, integral O15162 5359 3q24 human T161-p 11380906 CGPSRPFtLRIIDNM Scramblase activity, induced 10770950 1 0 0 +ELAVL1 HuR RNA-binding Q15717 1994 19p13.2 human K313-ub 12357891 NGYRLGDkILQVSFK RRM_1 molecular association, regulation RNA stability, inhibited ETEA(INDUCES) RNA(DISRUPTS) 23618873 1 4 7 +Mecp2 MECP2 Transcription, coactivator/corepressor Q00566 29386 Xq37 rat S80-p 452713 AVPEASAsPKQRRSI activity, induced; molecular association, regulation; acetylation; protein conformation cell growth, inhibited; transcription, inhibited HDAC2(INDUCES); DGCR8(INDUCES) DNA(INDUCES) 24441681; 24636259 12 68 1 represses miR-134 processing, promotes upregulation of CREB level; amyloid suppressed NLGN1 expression, and decreased acetylation of histone +CBL CBL Adaptor/scaffold; EC 6.3.2.-; EC 6.3.2.19; Ligase; Motility/polarity/chemotaxis; Oncoprotein; UBIQUITIN LIGASE; Ubiquitin conjugating system; Ubiquitin ligase P22681 867 11q23.3 human T640-p 23090718 DVPRLGStFSLDTSM protein stabilization; phosphorylation; neddylation cell cycle regulation; DNA repair, induced; cell growth, inhibited; signaling pathway regulation 31315051 1 1 1 enhances TBRII neddylation, stabilization and signaling, induces SMAD2/3 phosphorylation +CNTROB LIP8 Cell cycle regulation Q8N137 116840 17p13.1 human T35-p 27565612 NQVSSEVtSQLYASL cell motility, inhibited 23291182 1 0 0 +Yap1 YAP1 Oncoprotein; Transcription, coactivator/corepressor P46938 22601 9|9 A1 mouse S274-p 3190663 PPPLAPQsPQGGVLG intracellular localization cell cycle regulation; cytoskeletal reorganization; signaling pathway regulation 33046882 4 24 1 Hippo pathway +WEE1 Wee1 EC 2.7.10.2; KINASE; Kinase, protein; Protein kinase, Other; Protein kinase, Ser/Thr (non-receptor); Protein kinase, tyrosine (non-receptor) P30291 7465 11p15.4 human S123-p 451132 EEGFGSSsPVKSPAA protein degradation; molecular association, regulation; phosphorylation cell cycle regulation BTRC(INDUCES); PLK1(INDUCES); FBW1B(INDUCES) 15070733; 16085715; 23051732 3 0 0 primes PLK1 phosphorylation +BTK Btk EC 2.7.10.2; KINASE; Kinase, protein; Protein kinase, TK; Protein kinase, tyrosine (non-receptor) Q06187 695 Xq22.1 human T495-p 28710301 EMRHRFQtQQLLEMC PK_Tyr_Ser-Thr protein degradation; molecular association, regulation; ubiquitination; intracellular localization; phosphorylation signaling pathway regulation 14-3-3 zeta(INDUCES) 23754751 1 0 0 induces tyrosine phosphorylation and BCR signaling +Mlxipl ChREBP Transcription factor Q8VIP2 171078 12q12 rat T666-p 458376 KMENRRItHISAEQK HLH intracellular localization transcription, altered 11698644 2 0 0 inhibits the DNA-binding activity of ChREBP +ERBB2 HER2 EC 2.7.10.1; KINASE; Kinase, protein; Membrane protein, integral; Oncoprotein; Protein kinase, TK; Protein kinase, tyrosine (receptor) P04626 2064 17q12 human T701-p 472481 TELVEPLtPSGAMPN molecular association, regulation; receptor internalization, inhibited; protein conformation EGFR(DISRUPTS) 28632938 4 10 27 Suppression of HER2 Thr701 phosphorylation by MEK inhibitors increases HER2/EGFR heterodimerization +Skp2 SKP2 Cell cycle regulation; UBIQUITIN LIGASE; Ubiquitin conjugating system; Ubiquitin ligase Q9Z0Z3 27401 15|15 A1 mouse K68-ac 25673101 HPQSPPRkRVKGKGS protein stabilization; intracellular localization carcinogenesis, induced; cell motility, induced 22770219 2 1 0 Skp2 cytoplasmic localization +CLIP1 Restin iso3 Cytoskeletal P30622-2 6249 12q24.31 human T1384-p 36744502 EMFGHWAtNCNDDET CLIP1_ZNF molecular association, regulation; intracellular localization DYNC1I1(INDUCES); dynactin 1(INDUCES) 25413345 1 1 0 interaction with dynein?dynactin complexes; regulates localization of p150 to microtubule plus ends, and transport of EGFR containing endosomes +TPH1 TPH1 Amino Acid Metabolism - tryptophan; EC 1.14.16.4; Oxidoreductase P17752 7166 11p15.1 human S58-p 451575 RKSKRRNsEFEIFVD molecular association, regulation 14-3-3 beta(INDUCES) 9334190 4 1 0 Interaction with 14-3-3 leads to increase in enzymatic activity of TPH1 and its stabilization. The interaction also inhibits dephosphorylation of TPH1. +GSK3B GSK3B EC 2.7.11.1; EC 2.7.11.26; KINASE; Kinase, protein; Protein kinase, CMGC; Protein kinase, Ser/Thr (non-receptor) P49841 2932 3q13.33 human K197-ub 573764864 DPDTAVLkLCDFGSA Pkinase activity, inhibited 30711629 0 2 0 +PAGE4 PAGE4 Cancer Testis Antigen (CTA) O60829 9506 Xp11.23 human T94-p 63280105 PNPKHAKtKEAGDGQ GAGE protein conformation 28289210 1 1 0 +SEC14L2 SEC14L2 Lipid-binding O76054 23541 22q12.2 human S289-p 455526 VQISRGSsHQVEYEI activity, induced 15680919 1 0 0 +Dlg1 DLG1 Adaptor/scaffold; Motility/polarity/chemotaxis Q62696 25252 11q22 rat T209-p 35547401 VNTDSLEtPTYVNGT MAGUK_N_PEST molecular association, regulation; intracellular localization cytoskeletal reorganization GKAP1(DISRUPTS) 15729360 1 1 0 +Cd247 CD3Z Membrane protein, integral; Receptor, misc. P24161 12503 1 H2.3|1 73.14 cM mouse Y142-p 448932 GKGHDGLyQGLSTAT ITAM carcinogenesis, inhibited; apoptosis, induced; signaling pathway regulation 31285342; 37000627 15 24 410 induces TCR signaling; TCR signaling +WDR62 WDR62 Adaptor/scaffold O43379 284403 19q13.12 human S49-p 3175148 LRRRTRLsTASEETV cell cycle regulation 25501809; 26713495 2 23 202 WDR62 regulation of the mitotic spindle; S49/T50 is critical for spindle alignment and mitotic integrity; microtubule association +NFAT5 NFAT5 Transcription factor O94916 10725 16q22.1 human K668-m3 1884021300 KQQQIQPkAYNPETL activity, induced; protein stabilization; molecular association, regulation; intracellular localization transcription, induced TRAF6(DISRUPTS); STAM1(INDUCES); KPNB1(INDUCES) 37429858 1 1 0 enhanced MGMT transcription; nuclear localizationn; positively correlated with p-EGFR Y1068 and p-EZH2 S21 expression; methylation protects NFAT5 from ubiquitin-mediated lysosome degradation +AR AR DNA-binding; Nuclear receptor; Transcription factor P10275 367 Xq12 human S426-p 449807 AAGPGSGsPSAAASS Androgen_recep transcription, altered 15684382 3 1 0 +CFTR CFTR Channel, chloride; EC 3.6.3.49; Hydrolase; Membrane protein, integral; Membrane protein, multi-pass; Transporter; Transporter, ABC family P13569 1080 7q31.2 human T604-p 2907506 NKTRILVtSKMEHLK activity, induced 12588899; 14695900 2 0 1 +Kcnn2 KCNN2 Channel, potassium; Membrane protein, integral; Membrane protein, multi-pass P70604 54262 18q11 rat S465-p 460687 QAIHQLRsVKMEQRK CaMBD activity, induced 30771223 2 0 0 Alleviates voltage-dependent inhibition of SK channels by Ca2+. +Stmn1 STMN1 Cytoskeletal P54227 16765 4 D3|4 66.76 cM mouse S63-p 448557 AAEERRKsHEAEVLK Stathmin protein stabilization carcinogenesis, induced; cell motility, induced; cell growth, induced 36484700 26 56 32 +Smpd3 SMPD3 EC 3.1.4.12; Lipid Metabolism - sphingolipid; Membrane protein, integral; Phospholipase Q9JJY3 58994 8|8 D3 mouse S173-p 17547983 QIKIYIDsPTNTSIS enzymatic activity, induced 22074919 1 2 0 +RAD9A RAD9A Apoptosis; Cell cycle regulation; DNA replication; Deoxyribonuclease; EC 3.1.11.2 Q99638 5883 11q13.2 human S277-p 449811 SHSQDLGsPERHQPV phosphorylation cell cycle regulation 12734188; 20305300 4 22 4 +Sik2 QIK EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, CAMK; Protein kinase, Ser/Thr (non-receptor) Q8CFH6 235344 9|9 A5.3 mouse S587-p 3212040 FREGRRAsDTSLTQG molecular association, regulation signaling pathway regulation 14-3-3 beta(INDUCES) 32457359 4 35 17 PKA-SIK signaling for the regulation of sleep need +CDT1 CDT1 DNA replication; DNA-binding; Motility/polarity/chemotaxis; Oncoprotein Q9H211 81620 16q24.3 human T29-p 455584 PPKLACRtPSPARPA molecular association, regulation cell cycle regulation; transcription, inhibited SKP2(INDUCES) 15855168; 21856198 3 11 1 Cdt1 protein is degraded in S phase even in T29A mutant (even though it no longer co-IPs with Skp2). Overexpression of WT Cdt1 induced rereplication (DNA content >4N) and this was even greater in the T29A mutant.; T29 phosphorylation impairs HBO1 binding at replication origins in response to stress, inhibiting transcription. +Dusp6 DUSP6 EC 3.1.3.16; EC 3.1.3.48; Motility/polarity/chemotaxis; PHOSPHATASE; Protein phosphatase, dual-specificity Q9DBB1 67603 10|10 D1 mouse S159-p 455265 DGSCSSSsPPLPVLG protein degradation signaling pathway regulation 22521266 4 0 0 represses expression of gluconeogenic genes and glucose output +ITGB4 ITGB4 Cell adhesion; Membrane protein, integral; Motility/polarity/chemotaxis; Receptor, misc. P16144 3691 17q25.1 human S1360-p 451654 VLRSPSGsQRPSVSD molecular association, regulation Plectin-1(DISRUPTS) 17615294 4 0 5 +MSH3 MSH3 DNA repair, damage P20585 4437 5q14.1 human K103-ac 14367131 PVKKKVKkVQQKEGG intracellular localization 32900932 1 1 0 +Sik3 QSK EC 2.7.11.1; KINASE; Kinase, protein; Motility/polarity/chemotaxis; Protein kinase, CAMK; Protein kinase, Ser/Thr (non-receptor) Q6P4S6 70661 9|9 A5.2 mouse S609-p 1868968411 QRYLANRsKRHTLAM molecular association, regulation signaling pathway regulation 14-3-3 beta(INDUCES) 32457359 1 0 0 PKA-SIK signaling for the regulation of sleep need +ACTR2 ARP2 Actin-binding; Cytoskeletal; Motility/polarity/chemotaxis P61160 10097 2p14 human T238-p 36440501 QKLALETtVLVESYT Actin intracellular localization carcinogenesis, induced; cell motility, induced; cytoskeletal reorganization 25601402; 27872092; 33755220 4 0 0 +GRK2 GRK2 EC 2.7.11.15; KINASE; Kinase, protein; Protein kinase, AGC; Protein kinase, Ser/Thr (non-receptor) P25098 156 11q13.2 human Y13-p 456872 AVLADVSyLMAMEKS protein degradation; molecular association, regulation G-alpha(q)(INDUCES) 11566877; 16725308 5 0 0 +Dpysl2 CRMP-2 Microtubule-binding; Motility/polarity/chemotaxis P47942 25416 15p12 rat S522-p 448082 PASSAKTsPAKQQAP sumoylation; molecular association, regulation; intracellular localization endocytosis, induced; cell growth, altered ROCK2(DISRUPTS) 15483118; 24036111; 27940916 31 49 84 +AURKA AurA EC 2.7.11.1; KINASE; Kinase, protein; Oncoprotein; Protein kinase, Other; Protein kinase, Ser/Thr (non-receptor) O14965 6790 20q13.2 human T287-p 457654 HAPSSRRtTLCGTLD Pkinase enzymatic activity, inhibited; enzymatic activity, induced 15173575; 23924325 5 6 2 +TAOK1 TAO1 EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, STE; Protein kinase, Ser/Thr (non-receptor) Q7L7X3 57551 17q11.2 human T443-p 1880716204 EHFATIRtASLVTRQ molecular association, regulation Other(INDUCES) 36595571 1 1 0 induces binding to membrane phosphoinositides +HSPA1A HSP70 Chaperone; Heat shock protein; Motility/polarity/chemotaxis P0DMV8 3303 6p21.33 human R416-me 1877047301 VMTALIKrNSTIPTK HSP70 protein stabilization carcinogenesis, induced; cell growth, induced; apoptosis, inhibited RNA(INDUCES) 32699135 1 1 0 binding and stabilization of BCL2 mRNA +RNF187 RNF187 EC 6.3.2.-; EC 6.3.2.19; UBIQUITIN LIGASE; Ubiquitin conjugating system; Ubiquitin ligase Q5TA31 149603 1q42.13 human R109-me 347475301 GPLCAACrMAAGPEP protein stabilization; molecular association, regulation; protein conformation transcription, induced Jun(INDUCES) 23624934 1 1 0 dimerisation, expression of Jun target genes +STK39 STLK3 EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, STE; Protein kinase, Ser/Thr (non-receptor) Q9UEW8 27347 2q24.3 human T354-p 483899 IEKLLTRtPDIAQRA signaling pathway regulation 21733846 0 18 6 +Stat3 STAT3 DNA-binding; Motility/polarity/chemotaxis; Nuclear receptor co-regulator; Transcription factor P42227 20848 11 D|11 63.82 cM mouse K707-ac 475839 GSAAPYLkTKFICVT acetylation; phosphorylation transcription, inhibited SIRT1(INDUCES) 19295512 1 1 0 SIRT1 downregulates phosphorylation at STAT3-Y705 and transactivation, deacetylation of STAT3 +PPP1CC PPP1CC EC 3.1.3.16; Motility/polarity/chemotaxis; Nucleolus; PHOSPHATASE; Protein phosphatase, Ser/Thr (non-receptor) P36873 5501 12q24.11 human T307-p 3190033 EKKKPNAtRPVTPPR enzymatic activity, inhibited 10880350 1 4 4 in vitro +DDX5 DDX5 EC 3.6.4.13; Helicase; Nuclear receptor co-regulator; Nucleolus; RNA splicing; RNA-binding; Spliceosome P17844 1655 17q23.3 human R502-m2 476729 DRYSAGKrGGFNTFR P68HR molecular association, regulation XRN2(INDUCES) 31267554 1 5 9 represses R-loops +H3-3A H3F3A DNA-binding P84243 3020 1q42.12 human K79-m1 18545328 REIAQDFkTDLRFQS Histone molecular association, regulation L3MBTL iso4(INDUCES) 23583077 0 5 15 +ITCH ITCH iso2 EC 6.3.2.-; EC 6.3.2.19; Ligase; UBIQUITIN LIGASE; Ubiquitin conjugating system; Ubiquitin ligase Q96J02-2 83737 20q11.22 human S161-p 33522000 TTCSESAsQNDDGSR molecular association, regulation; enzymatic activity, induced HECTD1(DISRUPTS) 23435430 1 0 0 ubiquitination and degradation of c-FLIP and c-JUN +SLC12A2 NKCC1 Membrane protein, integral; Membrane protein, multi-pass; Transporter; Transporter, SLC family P55011 6558 5q23.3 human T230-p 459123 RIDHYRHtAAQLGEK AA_permease_N activity, induced 12145304 3 7 3 +PRPS1 PRPS1 Carbohydrate Metabolism - pentose phosphate pathway; EC 2.7.6.1; Kinase, other; Nucleotide Metabolism - purine P60891 5631 Xq22.3 human T228-p 34551795 DMADTCGtICHAADK Pribosyl_synth molecular association, regulation; enzymatic activity, induced DNA repair, induced; cell growth, induced Other(NOT_REPORTED) 34343500 1 1 1 inhibits ADP binding +UBR5 UBR5 EC 6.3.2.-; EC 6.3.2.19; Ligase; Nuclear receptor co-regulator; UBIQUITIN LIGASE; Ubiquitin conjugating system; Ubiquitin ligase O95071 51366 8q22.3 human S2483-p 480595 ENRKRHGsSRSVVDM translation, inhibited 28559278 1 9 9 translational repression of TRAF3 mRNA +Krt8 K8 Cytoskeletal Q10758 25626 7q36 rat S432-p 448540 SSYGGLTsPGFSYGM cytoskeletal reorganization 18708634 27 8 23 +DLG4 PSD-95 Adaptor/scaffold P78352 1742 17p13.1 human S25-p 3609100 DTPPLEHsPAHLPNQ protein stabilization; molecular association, regulation; protein conformation; palmitoylation neural plasticity PIN1(INDUCES) 32231520; 32256312 4 0 0 +METTL3 METTL3 EC 2.1.1.62; METHYLTRANSFERASE; Methyltransferase; RNA processing Q86U44 56339 14q11.2 human S43-p 483736 RNPEAALsPTFRSDS protein stabilization; molecular association, regulation; methylation carcinogenesis, induced; DNA repair, induced; cell differentiation, induced POLR2A(INDUCES); USP5(DISRUPTS) 32615088; 33217317 2 28 0 +OPN3 encephalopsin GPCR, family 1; Membrane protein, integral; Membrane protein, multi-pass; Receptor, GPCR Q9H1Y3 23596 1q43 human S380-p 25303237 FIITSDEsLSVDDSD carcinogenesis, induced 35180853 1 0 1 +PXN PXN iso2 Adaptor/scaffold; Cell adhesion; Cytoskeletal; Motility/polarity/chemotaxis P49023-2 5829 12q24.23 human S130-p 450228 KQKSAEPsPTVMSTS Paxillin cell cycle regulation; carcinogenesis, altered; transcription, altered 20628053 5 25 4 regulates Erk1/2-induced cell proliferation and transcription +Cd247 CD3Z Membrane protein, integral; Receptor, misc. P24161 12503 1 H2.3|1 73.14 cM mouse K54-ub 18381100 TALYLRAkFSRSAET TCR_zetazeta molecular association, regulation signaling pathway regulation ZAP70(DISRUPTS) 20637659 1 1 0 +EP300 p300 ACETYLTRANSFERASE; Acetyltransferase; EC 2.3.1.48; Motility/polarity/chemotaxis; Nuclear receptor co-regulator; Transcription, coactivator/corepressor Q09472 2033 22q13.2 human S2315-p 486263 RSPQPVPsPRPQSQP molecular association, regulation; enzymatic activity, induced transcription, altered SP1(NOT_REPORTED) 17623675 2 10 1 controls EGF-induced keratin 16 promoter activity ; regulates HAT activity of p300 +RAF1 RAF1 EC 2.7.11.1; KINASE; Kinase, protein; Oncoprotein; Protein kinase, Ser/Thr (non-receptor); Protein kinase, TKL P04049 5894 3p25.2 human S339-p 447743 PRGQRDSsYYWEIEA molecular association, regulation; intracellular localization; enzymatic activity, induced Bcl-2(INDUCES); MEK1(INDUCES) 10998357; 11274179; 12244094; 15849194; 9234708 9 1 1 +Prkaca PKACA EC 2.7.11.11; KINASE; Kinase, protein; Protein kinase, AGC; Protein kinase, Ser/Thr (non-receptor) P05132 18747 8|8 C2 mouse T198-p 448459 RVKGRTWtLCGTPEY Pkinase protein stabilization; protein conformation; enzymatic activity, induced; phosphorylation transcription, induced; signaling pathway regulation 15618230; 19965870; 22334660; 30753874; 36995368; 8395513; 9488457 34 48 277 +H3C1 H3 DNA-binding P68431 8350 6p22.2 human Y41-p 10897613 GVKKPHRyRPGTVAL Histone molecular association, regulation chromatin organization, altered; apoptosis, inhibited; transcription, induced; transcription, altered SMARCA4(INDUCES); HP1 alpha(DISRUPTS) 19783980; 21156283; 25553095; 27275536; 27799566; 32232334 7 3 4 +DAPK1 DAPK1 Apoptosis; Autophagy; EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, CAMK; Protein kinase, Ser/Thr (non-receptor) P53355 1612 9q21.33 human S308-p 448142 ARKKWKQsVRLISLC protein degradation; molecular association, regulation; enzymatic activity, inhibited; phosphorylation apoptosis, altered; cytoskeletal reorganization; cell adhesion, altered; cell growth, altered CHIP(DISRUPTS); NMDAR2B(DISRUPTS); MIB1(DISRUPTS); CAMK2A(INDUCES); Calmodulin(DISRUPTS) 11579085; 17324930; 20220139; 28614711; 32977471 11 4 0 inhibits phosphorylation of TPM3 +CAV1 caveolin-1 Adaptor/scaffold; Motility/polarity/chemotaxis; Nuclear receptor co-regulator Q03135 857 7q31.2 human Y14-p 448422 VDSEGHLyTVPIREQ activity, induced; molecular association, regulation; intracellular localization; enzymatic activity, altered; phosphorylation cell cycle regulation; carcinogenesis, induced; cell motility, induced; apoptosis, induced; cell adhesion, induced; cell adhesion, inhibited; signaling pathway regulation; cell growth, induced; cell motility, altered; cell growth, altered; endocytosis, inhibited; transcription, altered; endocytosis, induced; cell adhesion, altered; cytoskeletal reorganization; autophagy, inhibited CSK(INDUCES); GRB7(INDUCES); SHP-2(INDUCES); CDC42(INDUCES); MMP9(INDUCES); MFN2(INDUCES); RCV1(DISRUPTS); CTNNB1(INDUCES); DRP1(INDUCES); TRAF2(INDUCES) 11075810; 11805080; 12135605; 12925753; 15466865; 15692085; 16332692; 17190831; 18347068; 18922892; 20228056; 21705803; 24427291; 24632723; 29371975; 33928090; 34321069; 35413643; 35954304; 36421712 55 45 830 +HLA-DRB1 HLA-DRB1 Membrane protein, integral P01911 3123 6p21.32 human K254-ub 6140802 FIYFRNQkGHSGLQP intracellular localization 19117940 1 0 1 +STK24 MST3 EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, STE; Protein kinase, Ser/Thr (non-receptor) Q9Y6E0 8428 13q32.2 human T190-p 468211 DTQIKRNtFVGTPFW Pkinase enzymatic activity, induced cell motility, altered 17046825; 35413286 5 34 138 +RBBP5 RBBP5 Transcription, coactivator/corepressor Q15291 5929 1q32.1 human S350-p 6747300 VEYEEREsEFDIEDE molecular association, regulation ASH2L(INDUCES) 25593305 1 13 0 increases the catalytic activity of MLL3 +Ptpn2 PTPN2 EC 3.1.3.48; Motility/polarity/chemotaxis; PHOSPHATASE; Protein phosphatase, tyrosine (non-receptor) Q06180 19255 18|18 E1 mouse S298-p 3181136 ELSKEDLsPICDHSQ phosphorylation; enzymatic activity, induced carcinogenesis, induced; apoptosis, inhibited 37000627 1 29 17 dephosphorylates CD3Z +Tp53 p53 Activator; DNA-binding; Motility/polarity/chemotaxis; Nuclear receptor co-regulator; Transcription factor; Tumor suppressor P02340 22059 11 B3|11 42.83 cM mouse K370-ub 464659 SSYLKTKkGQSTSRH transcription, altered 15964796 9 0 0 p53K6R (K378/383/369/379/367/370/R) mutant is still ubiquitinated and shows normal stability of p53 before and after DNA damage +RBM4 RBM4 Nuclear receptor co-regulator; Nucleolus; RNA splicing; RNA-binding Q9BWF3 5936 11q13.2 human S309-p 476783 SYYGRDRsPLRRATA molecular association, regulation; intracellular localization translation, induced AGO2(DISRUPTS); EIF4A1(INDUCES) 17284590; 23897118 2 11 1 +Bdkrb2 BKR2 GPCR, family 1; Membrane protein, integral; Membrane protein, multi-pass; Receptor, GPCR P25023 25245 6q32 rat T167-p 457435 RYLALVKtMSMGRMR 7tm_1 receptor desensitization, altered; receptor internalization, altered; activity, inhibited 11807751; 9837936 2 0 0 +Casp9 CASP9 Apoptosis; EC 3.4.22.62; Protease Q8C3Q9 12371 4|4 E1 mouse T163-p 449563 PEVLRPEtPRPVDIG enzymatic activity, inhibited apoptosis, altered 19081073 7 4 10 +Sh3bp2 SH3BP2 Adaptor/scaffold Q06649 24055 5|5 B2 mouse Y183-p 449092 HEDEDDSyLEPDSPG molecular association, regulation PLCG2(INDUCES); VAV1(INDUCES) 19833725 4 0 0 positively regulates 3BP2-mediated transcriptional activation of NFAT +CBX4 CBX4 EC 6.3.2.-; SUMO LIGASE; SUMO conjugating system; SUMO ligase; Transcription, coactivator/corepressor O00257 8535 17q25.3 human K178-ub 573756664 LQYQGGHkEAPSPTC protein degradation 32111827 1 1 0 +Plekhf1 PKHF1 Q3TB82 72287 7|7 B3 mouse Y208-p 1868624702 LRVCSLCyRELAAQK FYVE molecular association, regulation endocytosis, induced; signaling pathway regulation caveolin-1(INDUCES) 31189603 1 0 0 endocytosis of bacteria +Nfatc2 NFAT1 DNA-binding; Transcription factor Q60591 18019 2 H3|2 88.91 cM mouse S54-p 455326 IAHKAISsPSGLAYP transcription, induced 11030334 0 1 0 +TLK1 TLK1 EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, Other; Protein kinase, Ser/Thr (non-receptor) Q9UKI8 9874 2q31.1 human S743-p 449050 PHMRRSNsSGNLHMA enzymatic activity, inhibited 12660173 3 0 0 +ACD ACD Adaptor/scaffold Q96AP0 65057 16q22.1 human K147-ub 25218502 QDLDVQKkLYDCLEE protein stabilization; molecular association, regulation; intracellular localization DNA repair, altered POT1(INDUCES) 22101936 1 0 0 induces telomere shortening and chromosome fusions via alternative NHEJ pathway +PNKP Pnk1 DNA-binding; EC 2.7.1.78; EC 3.1.3.32; Kinase, other; Phosphatase (non-protein) Q96T60 11284 19q13.33 human S126-p 460833 PPGTPLVsQDEKRDA molecular association, regulation; enzymatic activity, inhibited; intracellular localization; enzymatic activity, induced DNA repair, induced DNA(INDUCES) 21637298; 21824916 2 4 19 +KCNK1 KCNK1 Membrane protein, integral; Membrane protein, multi-pass O00180 3775 1q42.2 human K274-sm 3142603 FCELHELkKFRKMFY activity, inhibited 15820677; 20498050 3 1 0 +FGFR1 FGFR1 EC 2.7.10.1; KINASE; Kinase, protein; Membrane protein, integral; Oncoprotein; Protein kinase, TK; Protein kinase, tyrosine (receptor) P11362 2260 8p11.23 human Y654-p 447919 DIHHIDYyKKTTNGR PK_Tyr_Ser-Thr phosphorylation; enzymatic activity, induced cell differentiation, altered; cell motility, altered; cell growth, altered 16507368; 8622701 17 18 172 Double Y->F mutant has less neurite outgrowth in PC12 cells (differentiation), and less cell proliferation in L-6 cells.; Data collected by isolating phosphorylated species in vitro and confirming their phosphorylation states by mass spec. Y->F mutations were also done but unpublished. +Myb Myb DNA-binding; Oncoprotein; Transcription factor P06876 17863 10 A3|10 9.75 cM mouse T354-p 1308924 CLGEHHAtPSLPADP protein degradation 18006338 1 0 0 stress-induced degredation +RAD17 RAD17 Cell cycle regulation O75943 5884 5q13.2 human Y676-p 1868913301 ENIIIEDyESDGT__ molecular association, regulation; phosphorylation RAD1(INDUCES) 31353086 1 0 0 induces phosphorylation of other sites +APP APP Apoptosis; Cell surface; Membrane protein, integral; Receptor, misc.; Transcription factor P05067 351 21q21.3 human K726-ne 12124804 TLVMLKKkQYTSIHH APP_amyloid transcription, inhibited Fe65(DISRUPTS) 18096514 1 0 0 +PTTG1 Securin Cell cycle regulation; Oncoprotein O95997 9232 5q33.3 human S165-p 452603 LFQLGPPsPVKMPSP Securin protein stabilization; molecular association, regulation; phosphorylation carcinogenesis, altered; transcription, induced; signaling pathway regulation CTNNB1(INDUCES) 37400529 2 50 2 induces GSK3B dephosphorylation, regulates Wnt/?-catenin signaling +Arrb2 ARRB2 Adaptor/scaffold Q91YI4 216869 11 B3|11 42.99 cM mouse K296-ub 6140809 LALDGQLkHEDTNLA Arrestin_C molecular association, regulation mAChR M2(INDUCES); mAChR m1(INDUCES) 19055777 1 1 0 +PTK6 Brk EC 2.7.10.2; KINASE; Kinase, protein; Protein kinase, TK; Protein kinase, tyrosine (non-receptor) Q13882 5753 20q13.33 human Y447-p 450276 RLSSFTSyENPT___ molecular association, regulation; enzymatic activity, inhibited Akt1(DISRUPTS) 12121988; 14676834; 15539407 6 16 367 +Wnk4 WNK4 EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, Other; Protein kinase, Ser/Thr (non-receptor) Q80UE6 69847 11|11 D mouse S64-p 15504094 SRPSRRSsVDLGLLS enzymatic activity, induced 28096417 1 1 1 +Syk Syk EC 2.7.10.2; KINASE; Kinase, protein; Protein kinase, TK; Protein kinase, tyrosine (non-receptor) Q64725 25155 17p14 rat Y624-p 459326 ELRLRNYyYDVVN__ molecular association, regulation; phosphorylation; enzymatic activity, induced FCER1G(INDUCES) 20554527 3 2 5 mutation of this site stimulates phosphorylation of Y317, Y519 and Y520; required for activation of ERK1/2 and p38MAP kinases; required for activation of NFAT and NFkB +SMAD4 SMAD4 DNA-binding; Nuclear receptor co-regulator; Transcription, coactivator/corepressor Q13485 4089 18q21.2 human K113-sm 2793926 KNELKHVkYCQYAFD MH1 protein stabilization; intracellular localization transcription, induced; transcription, inhibited; signaling pathway regulation 12621041; 12740389; 14750902; 15028714 5 1 0 +STING1 STING Apoptosis; Endoplasmic reticulum; Membrane protein, integral; Membrane protein, multi-pass; Mitochondrial Q86WV6 340061 5q31.2 human K347-ub 1883300101 EVTVGSLkTSAVPST protein degradation 35871231 1 0 0 UFL1 reduces STING ubiquitination +Smad7 SMAD7 DNA-binding; Transcription factor O35253 17131 18|18 E3 mouse K70-ac 458990 GKAVRGAkGHHHPHP protein stabilization; ubiquitination apoptosis, induced 12408818; 17098745 2 1 0 inhibits ubiquitination further inducing protein stabilization; inhibits ubiquitination +APEX1 APE1 DNA repair, damage; DNA-binding; Deoxyribonuclease; EC 4.2.99.18; Endoplasmic reticulum; Hydrolase; Lyase; Nuclear receptor co-regulator; Nucleolus; Transcription, coactivator/corepressor P27695 328 14q11.2 human K7-ac 459076 _MPKRGKkGAVAEDG molecular association, regulation; enzymatic activity, inhibited; enzymatic activity, induced DNA repair, induced; cell growth, induced; DNA repair, inhibited; transcription, inhibited XRCC1(INDUCES); XRCC1(DISRUPTS) DNA(INDUCES) 14633989; 19934257; 27655688; 27994014 5 2 0 +PTPN12 PTP-PEST EC 3.1.3.48; Motility/polarity/chemotaxis; PHOSPHATASE; Protein phosphatase, tyrosine (non-receptor) Q05209 5782 7q11.23 human S19-p 18014400 QRVQAMKsPDHNGED enzymatic activity, inhibited cell motility, induced 28842430 2 11 2 selectively decreased its activity toward the human epidermal growth factor receptor (HER)-2 pY(1196) site +Mapk8 JNK1 EC 2.7.11.24; KINASE; Kinase, protein; Protein kinase, CMGC; Protein kinase, Ser/Thr (non-receptor) Q91Y86 26419 14|14 B mouse T183-p 447643 AGTSFMMtPYVVTRY Pkinase protein degradation; acetylation; molecular association, regulation; enzymatic activity, induced cell cycle regulation; carcinogenesis, induced; carcinogenesis, inhibited; cell growth, inhibited; apoptosis, induced; cell motility, induced; cell motility, inhibited; transcription, induced; signaling pathway regulation; transcription, altered; cell growth, induced; apoptosis, inhibited; transcription, inhibited p300(INDUCES); GSK3B(INDUCES); CTNNB1(INDUCES); PCAF(INDUCES) 18032450; 18952597; 21887248; 26306048; 34914791; 34962918; 35370650; 35637461; 36070687; 36310322 275 33 392 +AFAP1 AFAP Adaptor/scaffold Q8N556 60312 4p16.1 human Y453-p 3891002 PEALHYDyIDVEMSA molecular association, regulation Src(INDUCES) 9655255 1 0 0 Src Y529F Src mutant +USP31 USP31 DEUBIQUITINASE; EC 3.4.19.12; Protease; Ubiquitin-specific protease Q70CQ4 57478 16p12.2 human K1264-ac 1881321504 SSVKSVCkNTGDDEA enzymatic activity, inhibited carcinogenesis, induced; apoptosis, inhibited 34184746 1 1 0 acetylation of USP31 is beneficial for cancer cell growth +Gab2 GAB2 Adaptor/scaffold Q9Z1S8 14389 7|7 E1 mouse S160-p 448382 LLRERKSsAPSHSSQ molecular association, regulation; phosphorylation cell motility, inhibited; signaling pathway regulation SHP-2(DISRUPTS) 23401857 3 1 0 inhibits ERK1/2 phosphorylation, modulates Ras/MAPK signaling pathway +MAP2 MAP2 Cytoskeletal; Motility/polarity/chemotaxis P11137 4133 2q34 human S1710-p 456809 HVTSKCGsLKNIRHR Tubulin-binding molecular association, regulation; intracellular localization cytoskeletal reorganization TUBA1A(INDUCES); ACTB(INDUCES) 11029056 2 1 0 +NFATC3 NFAT4 DNA-binding; Transcription factor Q12968 4775 16q22.1 human S211-p 11507600 TLGSPLTsPGGSPGG intracellular localization 9630228 1 1 1 cytoplasmic localization (inhibition of nuclear localization) +NADK NADK Cofactor and Vitamin Metabolism - nicotinate and nicotinamide; EC 2.7.1.23; Kinase, other O95544 65220 1p36.33 human S64-p 467326 KEFRRTRsLHGPCPV enzymatic activity, induced carcinogenesis, induced 34133937 1 33 11 +CTNND1 CTNND1 iso3 Actin-binding; Adaptor/scaffold; Cell adhesion; G protein regulator, misc.; Motility/polarity/chemotaxis O60716-3 1500 11q12.1 human S269-p 470326 QVRVGGSsVDLHRFH molecular association, regulation signaling pathway regulation Kaiso(INDUCES); CDH1(DISRUPTS) 21670201 2 54 8 prevents Kaiso binding to Tcf-4 and B-catenin, induces Kaiso binding to CDKN2A promoter, inhibiting CDKN2A gene expression +PHF8 PHF8 DEMETHYLASE; Demethylase; EC 1.14.11.27; Nucleolus Q9UPP1 23133 Xp11.22 human S120-p 453946 GKPVKTGsPTFVREL cell growth, inhibited; cell differentiation, induced; transcription, induced 23518351 2 16 0 +SORBS2 ArgBP2 iso2 Adaptor/scaffold; Motility/polarity/chemotaxis O94875-2 8470 4q35.1 human Y175-p 7783536 YTYNAGLyNPPYSAQ protein conformation 24475245 1 0 1 reduced self-interaction +IDH2 IDH2 Carbohydrate Metabolism - citrate (TCA) cycle; EC 1.1.1.42; Mitochondrial; Other Amino Acids Metabolism - glutathione; Oxidoreductase P48735 3418 15q26.1 human Y107-p 1914598 SALATQKySVAVKCA Iso_dh intracellular localization 34289383 1 0 6 enhances ACAT1 recruitment +ECT2 ECT2 GEF; GEF, Rac/Rho; Motility/polarity/chemotaxis Q9H8V3 1894 3q26.31 human T846-p 457521 RAFSFSKtPKRALRR intracellular localization cell cycle regulation 22172673 2 5 4 +POU5F1 Oct4 DNA-binding; Transcription factor Q01860 5460 6p21.33 human K123-sm 486291 TVTPGAVkLEKEKLE protein degradation; protein stabilization; molecular association, regulation cell differentiation, inhibited; carcinogenesis, induced; transcription, induced DNA(INDUCES) 17525163; 23002208 4 0 0 +ABL2 Arg EC 2.7.10.2; KINASE; Kinase, protein; Oncoprotein; Protein kinase, TK; Protein kinase, tyrosine (non-receptor) P42684 27 1q25.2 human Y261-p 455657 GLVTTLHyPAPKCNK protein stabilization; ubiquitination 15735735 1 0 0 +BCR Bcr EC 2.7.11.1; GAP; GAP, Rac/Rho; GEF, Rac/Rho; KINASE; Kinase, protein; Oncoprotein; Protein kinase, Ser/Thr (non-receptor); Protein kinase, atypical P11274 613 22q11.23 human Y360-p 447796 VSPSPTTyRMFRDKS phosphorylation; enzymatic activity, induced 8622703; 9467953 4 1 29 +GPHN gephyrin Adaptor/scaffold; EC 2.10.1.1; EC 2.7.7.75 Q9NQX3 10243 14q23.3-q24.1 human S270-p 2020113 LSTTPSEsPRAQATS intracellular localization cytoskeletal reorganization 33796945 10 23 2 +THEM4 CTMP EC 3.1.2.2; Mitochondrial Q5T1C6 117145 1q21.3 human S38-p 9721502 PELRSFSsEEVILKD intracellular localization 19604401 1 1 0 +Kcnma1 KCNMA1 iso5 Channel, potassium; Endoplasmic reticulum; Membrane protein, integral; Membrane protein, multi-pass Q08460-5 16531 14|14 A3 mouse S1112-p 466425 QSSSKKSsSVHSIPS activity, induced 23407708 2 0 0 regulates NO/cGMP signaling +FKBP5 FKBP5 Chaperone; EC 5.2.1.8; Isomerase Q13451 2289 6p21.31 human K155-ac 63115302 IIRRTKRkGEGYSNP molecular association, regulation carcinogenesis, altered; apoptosis, induced PHLPP(DISRUPTS); Akt1(DISRUPTS) 28147277 1 1 0 induces Akt phosphorylation at S473 and enzymatic activation, regulates cancer cell sensitivity to genotoxic agents +Rims1 RIMS1 Adaptor/scaffold; Vesicle Q99NE5 116837 1|1 A5 mouse S413-p 4725270 TWHSRETsPISSHPV molecular association, regulation neural plasticity 14-3-3 eta(INDUCES) 15543142 1 3 0 Long-term potentiation +HNRNPU hnRNP U DNA-binding; Nuclear receptor co-regulator; RNA splicing; RNA-binding; Spliceosome Q00839 3192 1q44 human S14-p 18010531 NVKKLKVsELKEELK SAP molecular association, regulation; intracellular localization cell cycle regulation; chromatin organization, altered DNA(DISRUPTS) 33053167 1 5 0 +Nefl NFL Cytoskeletal P08551 18039 14|14 D1 mouse S63-p 2020617 SYSSSSGsLMPSLEN Filament_head molecular association, regulation; intracellular localization 14-3-3 gamma(INDUCES) 23230147 2 0 0 regulates NF-L dynamic exchange rate and neurofilament disassembly +UFD1 UFD1L DEUBIQUITINASE; Ubiquitin conjugating system; Ubiquitin-specific protease Q92890 7353 22q11.21 human S229-p 15428799 ELGFRAFsGSGNRLD protein stabilization; molecular association, regulation VCP(DISRUPTS) 31477623 1 7 1 phosphorylation of this site inhibits ER-associated degradation (ERAD) +Cacna1c CACNA1C Channel, calcium; Membrane protein, integral; Membrane protein, multi-pass Q01815 12288 6 F1|6 55.86 cM mouse S783-p 457631 KKLARTAsPEKKQEV activity, inhibited STX1A(DISRUPTS); SNAP-25(DISRUPTS) 16155576 1 0 0 +GBP1 GBP1 Cell adhesion; Hydrolase; Vesicle P32455 2633 1p22.2 human K51-ub 1879987800 VGLYRTGkSYLMNKL apoptosis, induced 31268602 1 0 0 required for IFN-gamma-enhanced cell death upon Toxoplasma infection +Pparg PPAR-gamma iso2 DNA-binding; Nuclear receptor; Transcription factor P37238-2 19016 6 E3|6 53.41 cM mouse S21-p 12170301 GISSVDLsVMEDHSH PPARgamma_N intracellular localization transcription, altered 20026644 1 0 0 +Ncf1 p47phox EC 1.-.-.-; Oxidoreductase Q09014 17969 5 G2|5 74.47 cM mouse S208-p 465580 KRGWVPAsYLEPLDS molecular association, regulation; phosphorylation CYBA(DISRUPTS) 33910977 2 0 0 inhibits AKT phosphorylation +PIP5K1C PIP5K1C Carbohydrate Metabolism - inositol phosphate; EC 2.7.1.68; Kinase, lipid; Motility/polarity/chemotaxis O60331 23396 19p13.3 human K97-ub 486880 TVGHLSSkPERDVLM protein degradation; molecular association, regulation carcinogenesis, induced; cell motility, induced; cell adhesion, induced; cytoskeletal reorganization talin 1(DISRUPTS) 23572508 1 8 97 invasion and metastasis +GFAP GFAP Cytoskeletal P14136 2670 17q21.31 human T7-p 449617 _MERRRItSAARRSY Filament_head protein stabilization 12177195 6 0 0 +AKT2 Akt2 EC 2.7.11.1; KINASE; Kinase, protein; Oncoprotein; Protein kinase, AGC; Protein kinase, Ser/Thr (non-receptor) P31751 208 19q13.2 human T309-p 448537 SDGATMKtFCGTPEY Pkinase intracellular localization; enzymatic activity, induced 9374542 16 5 23 +PHGDH PHGDH Amino Acid Metabolism - glycine, serine and threonine; Cell development/differentiation; EC 1.1.1.95; Oxidoreductase O43175 26227 1p12 human K330-ub 15394648 SAFSPHTkPWIGLAE PGDH_inter protein degradation carcinogenesis, inhibited; cell growth, inhibited 32478681; 35788583 2 1 1 +Kcnd3 Kv4.3 Channel, potassium; Membrane protein, integral; Membrane protein, multi-pass Q62897 65195 2q34 rat S569-p 455338 LPATRLRsMQELSTI activity, inhibited 18599872 2 1 2 +FOSL1 FRA1 DNA-binding; Transcription factor P15407 8061 11q13.1 human T227-p 50205700 LMTTPSLtPFTPSLV cell motility, induced; transcription, induced 27816489 2 0 0 +DDIT4 DDIT4 Q9NX09 54541 10q22.1 human K129-ub 4106211 QLVSQVGkELLRLAY RTP801_C molecular association, regulation HSC70(INDUCES) 36170669 1 11 60 +TP53 p53 Activator; DNA-binding; Motility/polarity/chemotaxis; Nuclear receptor co-regulator; Transcription factor; Tumor suppressor P04637 7157 17p13.1 human K372-ub 464660 HSSHLKSkKGQSTSR protein degradation; molecular association, regulation; intracellular localization transcription, inhibited ING1(DISRUPTS) 11046142; 17371868; 19927155; 21731648 9 0 0 K370/372/373/381/382/386/R mutant shows 613-fold activation of p53; binds unmodified or six multimonoubiquitinated forms of wild-type p53 +NUP98 NUP98 iso2 Motility/polarity/chemotaxis; Nucleoporin P52948-2 4928 11p15.4 human T529-p 3149520 AAQKALTtPTHYKLT intracellular localization 21335236 1 13 9 as multiple sites (13PM) mutant +Camk2b CAMK2B EC 2.7.11.17; KINASE; Kinase, protein; Protein kinase, CAMK; Protein kinase, Ser/Thr (non-receptor) P08413 24245 14q21 rat T325-p 48915805 RQTTAPAtMSTAASG molecular association, regulation 26291163 1 1 0 inhibits interaction with F-actin, regulates synaptic plasticity +IGF1R IGF1R EC 2.7.10.1; KINASE; Kinase, protein; Membrane protein, integral; Protein kinase, TK; Protein kinase, tyrosine (receptor) NP_999337 397350 pig Y1161-p 448386 FGMTRDIyETDYYRK PK_Tyr_Ser-Thr activity, induced 14976148 22 31 455 +EGFR EGFR EC 2.7.10.1; KINASE; Kinase, protein; Membrane protein, integral; Oncoprotein; Protein kinase, TK; Protein kinase, tyrosine (receptor) P00533 1956 7p11.2 human K739-ub 1065312 IPEGEKVkIPVAIKE PK_Tyr_Ser-Thr protein degradation 17940017 1 3 0 +TLR4 TLR4 Membrane protein, integral; Receptor, misc. O00206 7099 9q33.1 human R812-m2 1881518206 HIFWRRLrKALLDGK transcription, induced 34583098 1 0 0 IFN-? production in TLR4-/-BMDM cells +CIITA CIITA DNA-binding; EC 2.7.11.1; KINASE; Protein kinase, Ser/Thr (non-receptor); Transcription, coactivator/corepressor P33076 4261 16p13.13 human S834-p 448443 QELPGRLsFLGTRLT transcription, altered 11416140 1 1 0 +FBP1 FBPase Carbohydrate Metabolism - fructose and mannose; Carbohydrate Metabolism - glycolysis and gluconeogenesis; Carbohydrate Metabolism - pentose phosphate pathway; EC 3.1.3.11; Mitochondrial; Phosphatase (non-protein) P09467 2203 9q22.32 human S63-p 55578726 HLYGIAGsTNVTGDQ FBPase enzymatic activity, inhibited 27153534 1 1 0 +MERTK Mer EC 2.7.10.1; KINASE; Kinase, protein; Membrane protein, integral; Oncoprotein; Protein kinase, TK; Protein kinase, tyrosine (receptor) Q12866 10461 2q13 human Y749-p 449988 FGLSKKIySGDYYRQ PK_Tyr_Ser-Thr enzymatic activity, induced 8702477 1 13 435 +Dok2 DOK2 Adaptor/scaffold O70469 13449 14 D2|14 36.71 cM mouse Y351-p 447615 APLPDHIyDEPEGVA molecular association, regulation cell differentiation, altered; cell growth, altered NCK1(NOT_REPORTED); NCK1(INDUCES) 10428862; 10508618; 11689432; 12093790; 9764820 6 0 25 +H2AX H2AX DNA repair, damage; DNA-binding; Helicase P16104 3014 11q23.3 human K118-ub 3945263 IQAVLLPkKTSATVG Histone_H2A_C molecular association, regulation; intracellular localization; phosphorylation cell cycle regulation; DNA repair, induced UBE2T(INDUCES) 21690091; 33087136 6 15 167 ATM recruitment, H2AX S139 phosphorylation ; CHK1 phosphorylation and activation, cell cycle arrest, the DNA damage response and radioresistance +Mybpc3 MYBPC3 Myosin-binding O70468 17868 2|2 E1 mouse S282-p 471080 AGAGRRTsDSHEDAG activity, induced; molecular association, regulation; intracellular localization; protein conformation; phosphorylation apoptosis, altered; cytoskeletal reorganization MYH1(DISRUPTS); MYBPC1(DISRUPTS) 17075052; 21597010; 21978630; 22752314; 24001940; 24951619; 25740838; 26908877; 28167762; 31142654; 31796859 35 8 28 primes phosphorylation at other sites +RBM17 RBM17 RNA splicing; RNA-binding; Spliceosome Q96I25 84991 10p15.1 human S202-p 27936104 EEDSRPRsQSSKAAI molecular association, regulation; phosphorylation cell motility, induced; RNA stability, induced RNA(DISRUPTS) 23519612 1 0 0 induced cell invasion, enhanced Cortactin phosphorylation at ERK-dependent sites +Cacna1d CACNA1D Channel, calcium; Membrane protein, integral; Membrane protein, multi-pass P27732 29716 16p16 rat S1964-p 4771088 PPSHRRSsFNFECLR CAC1F_C activity, induced 18690020 2 1 0 enhancement of the current +Tfcp2l1 TFCP2L1 DNA-binding Q3UNW5 81879 1|1 E2.3 mouse S393-p 1875342302 LPQKQDDsGDNSLCV protein degradation; molecular association, regulation; ubiquitination; intracellular localization cell differentiation, induced BTRC(INDUCES) 34731635 1 0 0 +Slc40a1 SLC40A1 Membrane protein, integral; Membrane protein, multi-pass; Transporter; Transporter, SLC family Q9JHI9 53945 1|1 C1.1 mouse K253-ub 1872325200 LKQLTSPkDTEPKPL FPN1 receptor internalization, induced; protein degradation 17541408 1 0 0 SLC401A K253 internalization; regulation of iron transport (promotes aceruloplasminemia-an iron overload disease) +FANCL FANCL EC 6.3.2.-; EC 6.3.2.19; Ligase; UBIQUITIN LIGASE; Ubiquitin conjugating system; Ubiquitin ligase Q9NW38 55120 2p16.1 human T178-p 63128909 VPFCASWtPQSSLIS FANCL_d2 protein stabilization 23783032 1 0 0 +PXN PXN Adaptor/scaffold; Cell adhesion; Cytoskeletal; Motility/polarity/chemotaxis P49023 5829 12q24.23 human S272-p 465466 ELDELMAsLSDFKIQ molecular association, regulation cell adhesion, induced; cytoskeletal reorganization; transcription, inhibited TACE(INDUCES) 23317503; 32139877; 32155329 12 12 0 +PARD3 PAR3-alpha Adaptor/scaffold; Motility/polarity/chemotaxis Q8TEW0 56288 10p11.22-p11.21 human S873-p 3207429 VDDQKAGsPSRDVGP molecular association, regulation GAB1(DISRUPTS) 22883624 1 32 2 +NR1I2 PXR DNA-binding; Nuclear receptor O75469 8856 3q13.33 human K170-ac 1873076600 DTTFSHFkNFRLPGV intracellular localization cell motility, induced; cell adhesion, induced 28623334 1 0 0 TIP60-PXR complex +SMURF2 SMURF2 EC 6.3.2.-; EC 6.3.2.19; Ligase; UBIQUITIN LIGASE; Ubiquitin conjugating system; Ubiquitin ligase Q9HAU4 64750 17q23.3-q24.1 human K26-sm 52415801 LCAKNLVkKDFFRLP C2 signaling pathway regulation 26679521 2 0 0 regulation of TGF-beta induced epithelial-mesenchymal transition +LMNA lamin A/C Cytoskeletal P02545 4000 1q22 human S12-p 469170 SQRRATRsGAQASST molecular association, regulation lamin A/C(DISRUPTS) 35839855 1 38 17 +CDC25C CDC25C EC 3.1.3.48; Motility/polarity/chemotaxis; PHOSPHATASE; Protein phosphatase, dual-specificity P30307 995 5q31.2 human S214-p 448417 SRSGLYRsPSMPENL M-inducer_phosp molecular association, regulation; enzymatic activity, induced cell cycle regulation; cell adhesion, altered 14-3-3 beta(DISRUPTS) 12766774; 20530684; 8119945 4 6 10 +SF3B1 SF3B1 RNA splicing; RNA-binding; Spliceosome O75533 23451 2q33.1 human T248-p 455542 GSETPGAtPGSKIWD molecular association, regulation NIPP-1(INDUCES) 12105215 1 31 6 +MCM3 MCM3 DNA replication; EC 3.6.4.12 P25205 4172 6p12.2 human K270-ub 58948906 CNVKQMSkDAQPSFS cell cycle regulation 27621311 1 2 0 KEAP1-MCM3 associates with chromatin in a cell cycle-dependent manner +ELAVL1 HuR RNA-binding Q15717 1994 19p13.2 human S221-p 478357 QAQRFRFsPMGVDHM molecular association, regulation; intracellular localization; phosphorylation translation, altered; apoptosis, induced; RNA stability, induced; cell motility, altered; RNA stability, altered 14-3-3 theta(INDUCES); PKCA(INDUCES) RNA(INDUCES) 17392515; 18285462; 20086103; 23978401; 24492650; 28383062; 34406862; 34863979 11 0 0 +TBC1D4 AS160 GAP; GAP, Rab O60343 9882 13q22.2 human S751-p 455924 EGRKRTSsTCSNESL molecular association, regulation 14-3-3 epsilon(INDUCES) 20410134 10 10 48 multiple sites (6P) mutant +KCNK18 KCNK18 Channel, ligand-gated; Channel, potassium; Membrane protein, integral; Membrane protein, multi-pass Q7Z418 338567 10q25.3 human S262-p 13383300 ELVLGRLsYSIISNL intracellular localization; activity, inhibited transcription, inhibited 25202008; 30327410 4 0 0 +MARK3 MARK3 EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, CAMK; Protein kinase, Ser/Thr (non-receptor) P27448 4140 14q32.32-q32.33 human S215-p 450315 KLDTFCGsPPYAAPE Pkinase enzymatic activity, induced 12879020 2 11 12 +MAP1S BPY2-IP1 Apoptosis; Microtubule-binding Q66K74 55201 19p13.11 human K520-ac 1872903200 RKTEKEAkTPRELKK protein stabilization autophagy, induced 28386016 1 0 0 +XIAP XIAP Apoptosis; EC 6.3.2.-; Ligase; UBIQUITIN LIGASE; Ubiquitin conjugating system; Ubiquitin ligase P98170 331 Xq25 human S40-p 31884865 FANFPSGsPVSASTL BIR molecular association, regulation apoptosis, induced CASP3(DISRUPTS); CASP7(DISRUPTS) 27927753 1 1 0 +NR4A1 Nur77 Apoptosis; DNA-binding; Nuclear receptor P22736 3164 12q13.13 human T48-p 41583605 EAAPAAPtALPSFST cell motility, induced; cell growth, induced; cytoskeletal reorganization 26155943 1 0 0 required for increase in cell growth, cell motility, monolayer permeability, and formation of actin stress fibers. +MKNK1 Mnk1 EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, CAMK; Protein kinase, Ser/Thr (non-receptor); Translation Q9BUB5 8569 1p33 human T255-p 447622 ITTPELTtPCGSAEY Pkinase enzymatic activity, induced apoptosis, inhibited; cell growth, altered 17130135; 17590453; 18299328 13 1 0 Disruption of Mnk1 Mnk2 enhances As2O4 inducedapoptosis. +PLD1 PLD1 iso2 EC 3.1.4.4; Lipid Metabolism - ether lipid; Lipid Metabolism - glycerophospholipid; Motility/polarity/chemotaxis; Phospholipase Q13393-2 5337 3q26.31 human T147-p 448573 PIPTRRHtFRRQNVR PX intracellular localization; enzymatic activity, induced 16978840 5 0 0 +Ppara PPAR-alpha DNA-binding; Nuclear receptor; UBIQUITIN LIGASE P23204 19013 15 E2|15 40.42 cM mouse S12-p 1789802 ESPICPLsPLEADDL activity, induced 33214136 3 0 0 +Grik5 GluR KA2 Channel, ligand-gated; Membrane protein, integral; Membrane protein, multi-pass Q63273 24407 1q21 rat S840-p 31033001 SAESEEVsVCQEMLQ activity, induced 23066089 1 0 0 GluR KA2 mediated potentiation of heteromeric KARs +ERCC4 ERCC4 DNA repair, damage; Deoxyribonuclease; EC 3.1.-.- Q92889 2072 16p13.12 human K911-ac 1877232000 SFAEVVSkGKGKK__ molecular association, regulation DNA repair, induced ERCC1(INDUCES) 32034146 1 1 0 +RAF1 RAF1 EC 2.7.11.1; KINASE; Kinase, protein; Oncoprotein; Protein kinase, Ser/Thr (non-receptor); Protein kinase, TKL P04049 5894 3p25.2 human S499-p 450237 VKSRWSGsQQVEQPT PK_Tyr_Ser-Thr phosphorylation; enzymatic activity, induced 10998357; 8321321 2 0 0 may be required for S259 autophosphorylation +PRDX6 PRDX6 Amino Acid Metabolism - phenylalanine; EC 1.11.1.15; EC 1.11.1.9; Energy Metabolism - methane; Oxidoreductase; Phospholipase P30041 9588 1q25.1 human K142-sm 62925701 FVFGPDKkLKLSILY AhpC-TSA sumoylation; protein degradation 28055018 1 0 0 +DLC1 DLC1 GAP; GAP, Rac/Rho; Tumor suppressor Q96QB1 10395 8p22 human S745-p 37037500 TQTSSSSsQSETSSA activity, induced; molecular association, regulation; phosphorylation cell motility, inhibited 25525271 1 0 0 Phosphorylation at T738 and S745 is essential for DLC1-PP2A binding and dephosphorylation +Hmga1 HMGA1 DNA-binding Q8K585 117062 20p12 rat T78-p 451516 KTRKVTTtPGRKPRG molecular association, regulation DNA(DISRUPTS) 10617144 3 7 2 +MMP14 MMP14 EC 3.4.24.80; Membrane protein, integral; Motility/polarity/chemotaxis; Protease P50281 4323 14q11.2 human K581-ub 23299300 CQRSLLDkV______ DUF3377 intracellular localization 22315223 1 0 0 modulates trafficking and cell surface recycling of the protease, degradation of and invasion through type-I collagen +Ret Ret EC 2.7.10.1; KINASE; Kinase, protein; Membrane protein, integral; Oncoprotein; Protein kinase, TK; Protein kinase, tyrosine (receptor) P35546 19713 6 F1|6 55.86 cM mouse S697-p 451267 SSGTRRPsLDSTENQ activity, induced; phosphorylation cell motility, altered; cytoskeletal reorganization 17050626 5 7 0 S697A mice show aganglionosis in the distal colon due to an impaired migration of ENCCs. ENCCs lack chemoattraction to GDNF in culture, fewer GDNF-induced lamellipodia, and JNK activation. +HOXA10 HOXA10 DNA-binding; Transcription factor P31260 3206 7p15.2 human Y343-p 455550 GRKKRCPyTKHQTLE Homeodomain molecular association, regulation; activity, inhibited transcription, induced HOXA10(INDUCES) 12145285 1 0 0 phosphorylation decreases Hox-A10 DNA binding affinity and transcriptional repression activity. +RIPK1 RIPK1 EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, Ser/Thr (non-receptor); Protein kinase, TKL Q13546 8737 6p25.2 human D324-ca 31845900 RMQSLQLdCVAVPSS activity, inhibited apoptosis, induced 10521396 1 0 0 blockage of TNF-induced NF-kB activation +PECAM1 PECAM-1 Cell adhesion; Cell development/differentiation; Membrane protein, integral; Motility/polarity/chemotaxis P16284 5175 17q23.3 human Y713-p 448760 KKDTETVySEVRKAV activity, induced; molecular association, regulation; intracellular localization endocytosis, induced; cell motility, altered; cytoskeletal reorganization; cell adhesion, altered STAT5A(INDUCES); SH2D1B(NOT_REPORTED); SHP-2(INDUCES); Arg(NOT_REPORTED) 10704309; 11254359; 11927609; 12207897; 12535670; 15201144; 18182571; 23322602; 9298995; 9312087 14 20 786 internalization, stimulate actin stress fiber formation; induces switch from heterophilic to homophilic cell-cell aggregation +Trpm2 TRPM2 Channel, calcium; EC 3.6.1.13; Hydrolase; Membrane protein, integral; Membrane protein, multi-pass; Transporter Q91YD4 28240 10 C1|10 39.72 cM mouse T738-p 1879806400 GGIQAFLtKVWWGQL activity, induced 36042566 1 0 0 increases temperature threshold for activation +CTTN Cortactin Actin-binding; Cytoskeletal; Motility/polarity/chemotaxis Q14247 2017 11q13.3 human Y486-p 447704 YPAEDSTyDEYENDL molecular association, regulation cell motility, induced; cell adhesion, altered; cytoskeletal reorganization N-WASP(INDUCES) 15056655; 24188565; 29133485; 9748248 25 1 3 invadopodia formation; Tyrosine phosphorylation is necessary for enhanced S1P barrier enhancement. ; ECM invasion as well as transwell and 2D migration; Regulates membrane ruffling; required for maximal invasion of host cells by C.jejuni; Previous work by the authors showed that src attenuates the actin cross-linking activity of cortactin. These studies show that transfection with a cortactin mutant (F421/F470/F486) impairs the motility of endothelial cells. +Klf1 KLF1 C2H2-type zinc finger protein; DNA-binding; Transcription factor P46099 16596 8 41.3 cM|8 C3 mouse S50-p 31953300 PPNPTGPsLHVSLKS sumoylation; molecular association, regulation; intracellular localization KPNB1(INDUCES) 24576425 1 1 0 nuclear import of KLF1 by sumoylation at K56 +H3c1 H3 DNA-binding P68433 360198 13|13 A3.1 mouse K4-m1 1458622 ____ARTkQTARKST Histone endocytosis, altered; cell differentiation, induced; chromatin organization, altered; cell adhesion, altered; transcription, induced; transcription, altered 20543957; 29370269; 33195484 44 10 9 axon guidance +FSCN1 fascin Actin-binding; Cytoskeletal; Motility/polarity/chemotaxis Q16658 6624 7p22.1 human K471-ac 11324304 KVGGRYLkGDHAGVL Fascin cytoskeletal reorganization; cell motility, inhibited 34555274 1 4 0 inhibited cancer cell migration and tumor metastasis, modulating its bundling to F-actin +DUSP1 DUSP1 EC 3.1.3.16; EC 3.1.3.48; Motility/polarity/chemotaxis; PHOSPHATASE; Protein phosphatase, dual-specificity P28562 1843 5q35.1 human S364-p 448661 LQSPITTsPSC____ protein stabilization 10617468; 25204653 2 0 0 +ARHGEF2 ARHGEF2 iso2 GEF; GEF, Rac/Rho; Motility/polarity/chemotaxis Q92974-2 9181 1q22 human S959-p 467500 SRLSPPHsPRDFTRM activity, inhibited carcinogenesis, induced; cell motility, induced; cytoskeletal reorganization 22072711; 24043311 3 46 13 +Csnk1g2 CK1G2 EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, CK1; Protein kinase, Ser/Thr (non-receptor) Q8BVP5 103236 10|10 C1 mouse T215-p 1871246001 EHKSLTGtARYMSIN Pkinase molecular association, regulation; phosphorylation RIPK3(INDUCES) 33206046 1 1 0 inhibits phosphorylation of MLKL, binding to RIPK3 inhibits RIPK3 binding to RIPK1 +BECN1 beclin 1 Adaptor/scaffold; Autophagy; Membrane protein, peripheral Q14457 8678 17q21.31 human K402-ub 21129894 RMDVEKGkIEDTGGS APG6 protein degradation autophagy, inhibited 28445460 1 4 0 caused by mutant polyQ proteins +Crebbp CBP ACETYLTRANSFERASE; Acetyltransferase; DNA-binding; EC 2.3.1.48; Motility/polarity/chemotaxis; Nuclear receptor co-regulator; Transcription, coactivator/corepressor P45481 12914 16 A1|16 2.4 cM mouse Y1126-p 55377870 QLLGIPDyFDIVKNP Bromodomain cell differentiation, induced; signaling pathway regulation 30573679 1 2 0 regulates T-cell responses to infection, cytokine signaling pathway +ETS1 Ets-1 DNA-binding; Motility/polarity/chemotaxis; Oncoprotein; Transcription factor P13474 396235 chicken S282-p 449317 QSLQRVPsYDSFDSE Ets1_N_flank activity, inhibited 7961750 7 10 87 The in vitro interaction of Ets-1 with a high-affinity Ets binding site was assayed with EMSA. +SLC12A5 KCC2 Membrane protein, integral; Membrane protein, multi-pass; Transporter; Transporter, SLC family Q9H2X9 57468 20q13.12 human Y1110-p 3087801 NRNGDENyMEFLEVL SLC12 activity, inhibited 10942735 3 0 0 +LAT LAT iso2 Adaptor/scaffold; Membrane protein, integral O43561-2 27040 16p11.2 human Y191-p 448005 SLDGSREyVNVSQEL LAT activity, induced; molecular association, regulation; phosphorylation cell differentiation, altered; cell adhesion, altered; signaling pathway regulation; transcription, altered GRB2(INDUCES); PLCG1(INDUCES); GADS(INDUCES); THEMIS(INDUCES); TSAd(INDUCES) 11395491; 12496416; 15029250; 15100278; 23460737; 24412752; 27896837; 30510001; 34161759 40 4 54 induces Erk and calcium signaling +Pxn PXN Adaptor/scaffold; Cell adhesion; Cytoskeletal; Motility/polarity/chemotaxis Q8VI36 19303 5 F|5 56.1 cM mouse S250-p 3653284 SSPQRVTsSQQQTRI Paxillin intracellular localization cell motility, induced 23128389 2 3 17 requred for adhesion turnover +GJA1 GJA1 Channel, misc.; Membrane protein, integral; Membrane protein, multi-pass; Motility/polarity/chemotaxis P17302 2697 6q22.31 human S364-p 450183 AIVDQRPsSRASSRA protein conformation 23828237 6 8 0 +TWIST2 TWIST2 Q8WVJ9 117581 2q37.3 human K129-sm 1881202801 QSDEMDNkMTSCSYV protein stabilization cell motility, induced 33791162 1 0 0 ZNF451 promotes EMT, decreases the ubiquitination level of K129 +Cnr1 CNR1 GPCR, family 1; Membrane protein, integral; Membrane protein, multi-pass; Receptor, GPCR P47746 12801 4 A5|4 16.28 cM mouse T461-p 22342304 TVKIAKVtMSVSTDT receptor desensitization, induced 22014214 1 0 1 +GIT1 GIT1 GAP; GAP, ARF; Motility/polarity/chemotaxis Q9Y2X7 28964 17q11.2 human Y246-p 12243296 PDHKNGHyIIPQMAD molecular association, regulation; protein conformation; activity, inhibited cell motility, induced PXN(INDUCES) 24699139 1 1 0 +DEPTOR DEPTOR Apoptosis Q8TB45 64798 8q24.12 human T259-p 9764733 SHDNRKStSFMSVSP protein degradation; molecular association, regulation carcinogenesis, induced; apoptosis, inhibited; signaling pathway regulation mTOR(DISRUPTS) 19446321 2 2 0 PI3K-Akt signaling +APC2 APCL Membrane protein, peripheral O95996 10297 19p13.3 human S1164-p 23082768 LVLSRCSsVSSLGSF APC_r protein degradation; molecular association, regulation transcription, inhibited axin 1(INDUCES) 24722208 1 0 1 +EIF2AK2 PKR EC 2.7.10.2; EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, Other; Protein kinase, Ser/Thr (non-receptor); Protein kinase, tyrosine (non-receptor); Translation P19525 5610 2p22.2 human S542-p 15413409 TLTVWKKsPEKNERH phosphorylation carcinogenesis, induced; carcinogenesis, inhibited; cell motility, induced; cell growth, induced; apoptosis, induced; apoptosis, inhibited 32812257; 34799660 2 7 2 +NSD2 WHSC1 Amino Acid Metabolism - lysine degradation; EC 2.1.1.43; METHYLTRANSFERASE; Methyltransferase; Methyltransferase, protein lysine; Oncoprotein; Ubiquitin conjugating system O96028 7468 4p16.3 human S102-p 481737 DAKLRFEsQEMKGIG molecular association, regulation; methylation; intracellular localization MDC1(INDUCES); AGO2(INDUCES) 21293379; 26822153 2 6 1 +Foxo4 FOXO4 DNA-binding; Oncoprotein; Transcription factor Q9WVH3 54601 X D|X 43.89 cM mouse K189-ac 459043 PDGGKGGkAPRRRAA transcription, inhibited 16012755 2 1 0 +HIF1A HIF1A Autophagy; DNA-binding; Transcription factor Q16665 3091 14q23.2 human K19-ac 25126719 KISSERRkEKSRDAA protein degradation transcription, inhibited 21917920; 28319066 2 0 0 +Traf4 TRAF4 Adaptor/scaffold; DNA-binding; UBIQUITIN LIGASE; Ubiquitin conjugating system; Ubiquitin ligase Q61382 22032 11|11 B5 mouse K190-ub 40323300 HATSECPkRTQPCAY intracellular localization; enzymatic activity, induced carcinogenesis, induced; cell motility, induced 23760265 1 1 0 +Slc1a2 GLT1 Membrane protein, integral; Membrane protein, multi-pass; Transporter; Transporter, SLC family P31596 29482 3q32 rat K497-ub 4667702 GIVYHLSkSELDTID receptor internalization, induced; protein degradation 18805448 1 1 1 +RACGAP1 MgcRacGAP GAP; GAP, Rac/Rho Q9H0H5 29127 12q13.12 human S149-p 3211986 RLSTIDEsGSILSDI enzymatic activity, induced cell cycle regulation 35477750 1 3 0 induces Rho GTPase activity +Camk2b CAMK2B EC 2.7.11.17; KINASE; Kinase, protein; Protein kinase, CAMK; Protein kinase, Ser/Thr (non-receptor) P08413 24245 14q21 rat T328-p 34358436 TAPATMStAASGTTM molecular association, regulation 26291163 1 1 1 inhibits interaction with F-actin, regulates synaptic plasticity +Pln PLB Inhibitor; Membrane protein, integral P61016 64672 20q11 rat S16-gl 14738100 RSAIRRAsTIEMPQQ Phospholamban molecular association, regulation SERCA2(INDUCES) 20484118 1 0 0 PUGNAc tereatment +ARHGEF7 ARHGEF7 GEF; GEF, Rac/Rho; Motility/polarity/chemotaxis Q14155 8874 13q34 human S518-p 454356 LSASPRMsGFIYQGK PH exocytosis, induced 25009260 2 102 7 dopamine release +RELA NFkB-p65 DNA-binding; Nuclear receptor co-regulator; Transcription factor Q04206 5970 11q13.1 human S316-p 31880654 FKSIMKKsPFSGPTD activity, induced; intracellular localization transcription, induced 26082493 1 3 0 nuclear translocation +KAT5 Tip60 ACETYLTRANSFERASE; Acetyltransferase; EC 2.3.1.48; Nuclear receptor co-regulator; Nucleolus Q92993 10524 11q13.1 human K104-ac 33362432 ASAQASGkTLPIPVQ protein degradation; intracellular localization apoptosis, altered 25301942 1 3 0 HDAC3 increased the TIP60 half-life, and the ubiquitination level of TIP60, nuclear localization, cytoplasm and nucleus with HDAC3 expressed, TIP60 deacetylation increases its resistance to apoptosis +RIGI RIGI EC 3.6.4.13; Hydrolase O95786 23586 9p21.1 human S855-p 17484201 PKPKQFSsFEKRAKI RIG-I_C-RD molecular association, regulation; enzymatic activity, inhibited RIGI(DISRUPTS) 21068236 2 3 0 dephosphorylation of T770, S855, S854 stimulates multimer formation; +PARK7 DJ-1 EC 3.4.-.-; Nuclear receptor co-regulator; Transcription regulation; Tumor suppressor Q99497 11315 1p36.23 human T154-p 2566111 EKDGLILtSRGPGTS DJ-1_PfpI protein stabilization; molecular association, regulation; intracellular localization DJ-1(INDUCES) 31353306 2 3 0 +HHEX HHEX DNA-binding; Transcription factor Q03014 3087 10q23.33 human S177-p 7430501 LAKMLQLsERQVKTW Homeodomain molecular association, regulation transcription, induced DNA(INDUCES) 19324893 2 0 0 +Atoh1 ATOH1 Cell development/differentiation; DNA-binding; Transcription factor P48985 11921 6 C1|6 30.03 cM mouse Y78-p 386186604 CTARAAQyLLHSPEL protein stabilization cell growth, induced; transcription, induced 29168692 1 1 0 +GTF2A1 GTF2A1 Transcription, coactivator/corepressor P52655 2957 14q31.1 human S281-p 449823 DGTGDTSsEEDEDEE TFIIA transcription, induced 11278496 1 0 0 +TSC2 TSC2 Cell cycle regulation; GAP; GAP, misc.; Nuclear receptor co-regulator; Tumor suppressor P49815 7249 16p13.3 human S1798-p 454016 GQRKRLIsSVEDFTE activity, inhibited 15342917; 27451907 5 16 74 cell survival induced +Musk MUSK EC 2.7.10.1; KINASE; Kinase, protein; Membrane protein, integral; Protein kinase, TK; Protein kinase, tyrosine (receptor) Q62838 rat Y755-p 2848300 NIYSADYyKADGNDA PK_Tyr_Ser-Thr phosphorylation; enzymatic activity, induced 10619845 1 2 0 promotes MuSK phosphorylation; promotes AChRb clustering and phosphorylation +MPL MPL Membrane protein, integral; Receptor, cytokine P40238 4352 1p34.2 human Y631-p 450266 HSYLPLSyWQQP___ molecular association, regulation carcinogenesis, induced; cell differentiation, induced; signaling pathway regulation tensin 2(INDUCES) 21527831; 33384332; 36229456 8 0 0 regulates TPO mediated signaling; regulates TPO-R signaling +Kcnj11 Kir6.2 Channel, potassium; Membrane protein, integral; Membrane protein, multi-pass Q61743 16514 7 B3|7 29.66 cM mouse T224-p 453090 MQVVRKTtSPEGEVV IRK_C activity, induced 10698936 3 0 0 +ATF2 ATF-2 ACETYLTRANSFERASE; C2H2-type zinc finger protein; EC 2.3.1.48; Transcription factor P15336 1386 2q31.1 human S62-p 451440 FGPARNDsVIVADQT activity, induced; protein stabilization transcription, induced 15105425 2 9 29 +ABCF1 ABCF1 RNA-binding; Translation Q8NE71 23 6p21.33 human S109-p 453457 KKLSVPTsDEEDEVP molecular association, regulation 17894550 1 105 8 S109 aqnd S140 phosphorylation may affect ABCF1-eIF2 binding to 60S 80S subunits and small polysomes. +PTPN11 SHP-2 EC 3.1.3.48; Motility/polarity/chemotaxis; PHOSPHATASE; Protein phosphatase, tyrosine (non-receptor) Q06124 5781 12q24.13 human Y62-p 449573 KIQNTGDyYDLYGGE SH2 molecular association, regulation; protein conformation; phosphorylation; enzymatic activity, induced carcinogenesis, inhibited; signaling pathway regulation Other(DISRUPTS) 33727228; 35311954 1 70 2048 inhibits binding to SHP099, regulates ERK phosphorylation; inhibits PI3K/AKT pathway and induces activation of the RAS/MAPK signaling +SREBF1 SREBP-1 iso3 DNA-binding; Membrane protein, integral; Membrane protein, multi-pass; Transcription factor P36956-3 6720 17p11.2 human S93-p 469986 YPSMPAFsPGPGIKE transcription, induced 25353341 5 6 0 mRNA expression of central SREBP-1 target genes; Phosphorylation interferes with lipid metabolism and the secretory activity of liver cells. +ACIN1 acinus Apoptosis; RNA splicing; RNA-binding; Spliceosome Q9UKV3 22985 14q11.2 human S1180-p 456759 GPRSRSRsRDRRRKE RSB_motif intracellular localization transcription, induced 18559500 4 2 0 +FGFR1 FGFR1 EC 2.7.10.1; KINASE; Kinase, protein; Membrane protein, integral; Oncoprotein; Protein kinase, TK; Protein kinase, tyrosine (receptor) P11362 2260 8p11.23 human Y463-p 448641 MLAGVSEyELPEDPR molecular association, regulation cell cycle regulation; transcription, altered; cell growth, altered CRK(INDUCES) 10464310; 9880324 6 4 8 Phosphorylation of either Y463 or Y730, dispensable for mitogenic signaling, represents an absolute requirement for FGF2-mediated uPA induction +CCR7 CCR7 GPCR, family 1; Membrane protein, integral; Membrane protein, multi-pass; Motility/polarity/chemotaxis; Receptor, GPCR P32248 1236 17q21.2 human T373-p 455288 MSVEAETtTTFSP__ phosphorylation 15054093 1 0 0 ERK1/2 phosphorylation +SSB SSB Transcription initiation complex P05455 6741 2q31.1 human K41-sm 12004401 KFLKEQIkLDEGWVP La molecular association, regulation; intracellular localization DNAH1(INDUCES); KIF5B(DISRUPTS) RNA(INDUCES) 17646655; 27224031 2 0 0 No difference in CK2-dependent SSB phosphorylation at S366 in K41R/200R mutant and WT; induces retrograde transport +SLC12A1 NKCC2 Membrane protein, integral; Membrane protein, multi-pass; Transporter; Transporter, SLC family P55015 100328575 rabbit T99-p 458227 TNTYYLQtFGHNTMD AA_permease_N activity, induced 16077079 15 2 0 +PAX3 PAX3 DNA-binding; Oncoprotein; Transcription factor P23760 5077 2q36.1 human K475-ac 25042101 YGQYGQSkPWTF___ molecular association, regulation cell growth, inhibited; cell differentiation, induced; transcription, altered DNA(INDUCES) 21169561 1 0 0 K437 decreases Hes1 transcription, K437 and K475 increase transcription of Neurog2 +MAP3K6 MEKK6 EC 2.7.11.25; KINASE; Kinase, protein; Protein kinase, STE; Protein kinase, Ser/Thr (non-receptor) O95382 9064 1p36.11 human S964-p 4270162 SPPKRCLsYGGTSQL molecular association, regulation 14-3-3 gamma(INDUCES) 19935702 1 6 0 regulation of ASK1 function through the interaction +ESPL1 separase EC 3.4.22.49; Protease Q14674 9700 12q13.13 human T1363-p 1211205 AGPHVPFtVFEEVCP enzymatic activity, inhibited CDK1(INDUCES) 17974570 1 1 0 phosphorylation of S1399 is a key residue in CDK1-dependent inhibition of separase +PGAM1 PGAM1 Carbohydrate Metabolism - glycolysis and gluconeogenesis; EC 3.1.3.13; EC 5.4.2.11; EC 5.4.2.4; Isomerase; Phosphatase (non-protein) P18669 5223 10q24.1 human Y92-p 454756 WRLNERHyGGLTGLN His_Phos_1 enzymatic activity, induced 27991922 3 59 2247 +KIF20A KIF20A Microtubule-binding; Motor O95235 10112 5q31.2 human T857-p 471862 LRNLLPRtPTCQSST molecular association, regulation; intracellular localization; protein conformation cell cycle regulation AurB(DISRUPTS); INCENP(DISRUPTS) 24656812 1 10 35 favours solubility, inhibits microtubule binding +HELLS HELLS Apoptosis; EC 3.6.1.-; EC 3.6.4.-; Helicase Q9NRZ9 3070 10q23.33 human R309-me 1870757300 YHGTQEErQKLVRNI SNF2-rel_dom carcinogenesis, inhibited 32994405 1 1 0 +EIF2AK2 PKR EC 2.7.10.2; EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, Other; Protein kinase, Ser/Thr (non-receptor); Protein kinase, tyrosine (non-receptor); Translation P19525 5610 2p22.2 human T89-p 3753307 VSPLLLTtTNSSEGL enzymatic activity, induced 11152499 1 1 0 +Fndc5 FNDC5 Membrane protein, integral Q8K4Z2 384061 4|4 D2.2 mouse K185-ac 1881215701 DNEPNNNkEKTKSAS ubiquitination 33754067 1 0 0 SIRT2-dependent deacetylation and deubiquitination increases stability +HBP1 HBP1 DNA-binding; Transcription factor O60381 26959 7q22.3 human S380-p 3252925 MARQRRAsLSCGGPG activity, induced; protein stabilization cell growth, inhibited; apoptosis, induced; transcription, altered DNA(INDUCES) 28348080 1 10 53 HBP1-mediated DNMT1 repression and p16 activation +RAB11FIP5 RAB11FIP5 Cytoskeletal Q9BXF6 26056 2p13.2 human T276-p 32674000 GPGAELLtRSPSRSS molecular association, regulation; intracellular localization cell cycle regulation SNX18(DISRUPTS) 24591568 1 0 0 regulates apical lumen formation +SKP2 SKP2 Cell cycle regulation; UBIQUITIN LIGASE; Ubiquitin conjugating system; Ubiquitin ligase Q13309 6502 5p13.2 human K71-ac 25673100 SPPRKRLkSKGSDKD protein stabilization; intracellular localization carcinogenesis, induced; cell motility, induced SKP2(INDUCES) 22770219; 23230084 2 0 0 +KMT2E MLL5 Cell cycle regulation; EC 2.1.1.43; METHYLTRANSFERASE; Methyltransferase; Methyltransferase, protein lysine; Transcription, coactivator/corepressor Q8IZD2 55904 7q22.3 human T440-gl 7482007 IHSIPKGtEITIAFD SET methylation; enzymatic activity, induced cell differentiation, induced; transcription, induced 19377461 1 0 0 increases methylation at H3K4, induces retinoic acid-induced granulopoiesis +CTH CTH Amino Acid Metabolism - cysteine and methionine; Amino Acid Metabolism - glycine, serine and threonine; Cell cycle regulation; EC 4.4.1.1; Energy Metabolism - nitrogen; Lyase; Other Amino Acids Metabolism - selenoamino acid P32929 1491 1p31.1 human K73-ac 19011380 PTRNCLEkAVAALDG Cys_Met_Meta_PP protein stabilization 32755037 1 1 0 K70R mutant is resistant to both acetylation and ubiquitination and is more stable than WT +PLCB3 PLCB3 Carbohydrate Metabolism - inositol phosphate; EC 3.1.4.11; Phospholipase Q01970 5331 11q13.1 human S537-p 448450 PSLEPQKsLGDEGLN cell motility, induced 35884879 6 36 7 +MAX MAX DNA-binding; Transcription factor P61244 4149 14q23.3 human K153-ac 474515 PEEPQSRkKLRMEAS molecular association, regulation; intracellular localization transcription, induced B-Myc(INDUCES) DNA(DISRUPTS) 17217336 1 1 0 +CTTN Cortactin Actin-binding; Cytoskeletal; Motility/polarity/chemotaxis Q14247 2017 11q13.3 human K124-ac 461719 SVRGFGGkFGVQMDR HS1_rep molecular association, regulation; intracellular localization cell motility, inhibited ACTB(DISRUPTS) 17643370 1 3 10 Acetylation prevents localization to membrane ruf?es. +EHMT2 EHMT2 Amino Acid Metabolism - lysine degradation; EC 2.1.1.43; METHYLTRANSFERASE; Methyltransferase; Methyltransferase, protein lysine Q96KQ7 10919 6p21.33 human K465-sm 1878097303 GCNAAILkRETMRPS molecular association, regulation; intracellular localization cell cycle regulation; cell growth, induced; transcription, induced PCAF(INDUCES) 30867409 1 0 0 SUMOylated G9a is recruited to E2F1 target gene promoters, EHMT2 is an activator of proliferation and E2F1-target gene expression +ADRA1D ADRA1D GPCR, family 1; Membrane protein, integral; Membrane protein, multi-pass; Receptor, GPCR P25100 146 20p13 human S515-p 1346843001 TQLRAKVsSLSHKIR receptor internalization, induced; molecular association, regulation; intracellular localization; receptor internalization, altered signaling pathway regulation ARRB1(INDUCES) 29551601; 30419287 2 1 0 triggers the calcium signaling pathway; regulates ERK signaling pathway, induces calcium signaling de-sensitization +RPA2 RFA2 DNA replication P15927 6118 1p35.3 human S33-p 448339 GFGSPAPsQAEKKSR molecular association, regulation; intracellular localization; phosphorylation cell cycle regulation; DNA repair, induced; apoptosis, altered; cell growth, induced; DNA repair, inhibited; cell growth, altered WRN(INDUCES); CDC5L(INDUCES) 17035231; 19704001; 19843584; 21107010; 21664290; 23684611; 24332808; 24639502; 24876101; 26237679; 28046023; 33870196; 34385259 45 2 0 +Gabra4 GABRA4 Channel, chloride; Channel, ligand-gated; Membrane protein, integral; Membrane protein, multi-pass; Transporter; Transporter, ion channel Q9D6F4 14397 5|5 C3.1-C3.2 mouse S472-p 17390700 PASLGSAsTRPAFGS Neur_chan_memb protein stabilization; intracellular localization 20940303 2 1 0 increases receptor cell surface expression +PRKN PARK2 EC 6.3.2.-; EC 6.3.2.19; Ligase; Translation; Translation regulation; UBIQUITIN LIGASE; Ubiquitin conjugating system; Ubiquitin ligase O60260 5071 6q26 human S110-p 1872827402 TRVDLSSsVLPGDSV ubiquitination; intracellular localization; phosphorylation; enzymatic activity, induced autophagy, induced 33827825 1 1 0 induces phosphorylation at S65 and ubiquitination of substrates +CDK5 CDK5 Cell cycle regulation; EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, CMGC; Protein kinase, Ser/Thr (non-receptor) Q00535 1020 7q36.1 human T77-p 900975700 LHSDKKLtLVFEFCD Pkinase enzymatic activity, inhibited 29511352 1 0 0 +ERBB4 HER4 EC 2.7.10.1; KINASE; Kinase, protein; Membrane protein, integral; Protein kinase, TK; Protein kinase, tyrosine (receptor) Q15303 2066 2q34 human Y1188-p 451501 QALDNPEyHNASNGP molecular association, regulation GRB2(INDUCES); Arg(INDUCES); SHC1(INDUCES) 16729043; 18721752; 8617750 2 1 0 +L1cam NCAM-L1 Cell adhesion; Membrane protein, integral P11627 16728 X A7.3|X 37.43 cM mouse Y1232-p 10272401 DGSFIGQySGKKEKE Bravo_FIGEY molecular association, regulation cell growth, inhibited ANK1(DISRUPTS) 22579729 5 0 4 +Pdpk1 PDK1 EC 2.7.11.1; KINASE; Kinase, protein; Nuclear receptor co-regulator; Protein kinase, AGC; Protein kinase, Ser/Thr (non-receptor) O55173 81745 10q12 rat Y376-p 447694 SEDDEDCyGNYDNLL enzymatic activity, induced translation, altered; cell adhesion, altered 18559349 9 1 0 Induces fibronectin expression and deposition and increases AngII mesangial cell hypertrophy +RELA NFkB-p65 DNA-binding; Nuclear receptor co-regulator; Transcription factor Q04206 5970 11q13.1 human K123-ub 25087012 LGIQCVKkRDLEQAI RHD_DNA_bind transcription, inhibited 21706061 1 2 0 inhibits acetylation +CDC73 CDC73 Cell cycle regulation; Tumor suppressor Q6P1J9 79577 1q31.2 human Y290-p 3449102 KQPIPAAyNRYDQER CDC73_N molecular association, regulation; protein conformation transcription, inhibited; signaling pathway regulation CTNNB1(DISRUPTS) 21726809 1 0 1 inhibits Wnt signaling pathway +Bcar1 P130Cas Adaptor/scaffold; Motility/polarity/chemotaxis Q61140 12927 8|8 E1 mouse Y253-p 448721 APGPQDIyDVPPVRG carcinogenesis, induced; cell motility, induced; cell motility, altered 20430882; 21963850 14 44 723 SH3 and CCH domains are required for P130Cas tyrosine phosphorylation and promoting cell migration. ; migration, invasion, metastasis +ALK ALK EC 2.7.10.1; KINASE; Kinase, protein; Membrane protein, integral; Oncoprotein; Protein kinase, TK; Protein kinase, tyrosine (receptor) Q9UM73 238 2p23.2-p23.1 human Y1359-p 1016332 KNCPGPVyRIMTQCW PK_Tyr_Ser-Thr molecular association, regulation cell growth, altered Src(INDUCES) 14563642 2 3 5 +CHEK2 Chk2 EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, CAMK; Protein kinase, Ser/Thr (non-receptor); Tumor suppressor O96017 11200 22q12.1 human K249-ac 1878180000 TCKKVAIkIISKRKF enzymatic activity, induced 30902968 1 0 0 DDR-mediated cell death in oxidative stress +Gdpd5 GDPD5 EC 3.1.-.-; Membrane protein, integral; Membrane protein, multi-pass; Phosphodiesterase Q640M6 233552 7|7 E1 mouse T587-p 27930802 ANANSTAtPVGPRNA enzymatic activity, induced 23589856 1 1 0 +TP53 p53 Activator; DNA-binding; Motility/polarity/chemotaxis; Nuclear receptor co-regulator; Transcription factor; Tumor suppressor P04637 7157 17p13.1 human S20-p 447529 PLSQETFsDLWKLLP P53_TAD activity, induced; protein degradation; protein stabilization; molecular association, regulation; intracellular localization; protein conformation; phosphorylation cell cycle regulation; carcinogenesis, induced; apoptosis, altered; cell growth, inhibited; apoptosis, induced; transcription, induced; transcription, altered; cell growth, induced; cell growth, altered S100B(INDUCES); DACH1(INDUCES); S100A1(INDUCES); S100A4(INDUCES); CBP(INDUCES); MDM2(DISRUPTS); S100A6(INDUCES); MED17(INDUCES); p300(INDUCES); Chk2(INDUCES); S100A2(INDUCES) DNA(INDUCES) 10570149; 10673500; 11030628; 11258706; 11397945; 11551930; 11861384; 11896587; 12810724; 12860987; 14665630; 15471885; 15671037; 16651424; 17121812; 17339337; 18778462; 19819244; 20024960; 20962272; 21454683; 23798621; 25584963; 26742101; 27753536; 33514736; 35951367; 36007676 127 2 0 CRp53 +GPBAR1 GPBAR1 GPCR, family 1; Membrane protein, integral; Membrane protein, multi-pass; Receptor, GPCR Q8TDU6 151306 2q35 human S310-p 1877729200 WGRASRDsPGPSIAY molecular association, regulation cell growth, induced; apoptosis, inhibited ARRB1(INDUCES) 35858343 0 1 0 +PRKAA2 AMPKA2 Autophagy; EC 2.7.11.1; EC 2.7.11.27; EC 2.7.11.31; KINASE; Kinase, protein; Protein kinase, CAMK; Protein kinase, Ser/Thr (non-receptor) P54646 5563 1p32.2 human Y436-p 58109404 EWKVVNAyHLRVRRK AdenylateSensor enzymatic activity, inhibited autophagy, inhibited 27626315 1 0 0 TNF induced inhibition of autophagy +Arhgef2 ARHGEF2 GEF; GEF, Rac/Rho; Motility/polarity/chemotaxis Q60875 16800 3|3 F1 mouse S885-p 451365 PLDPRRRsLPAGDAL activity, induced; molecular association, regulation; activity, inhibited cytoskeletal reorganization 14-3-3 beta(INDUCES); DYNLT1(DISRUPTS); 14-3-3 eta(INDUCES) 19667072; 22405273; 24270516; 33740666 12 47 145 +Sstr2 SSTR2 GPCR, family 1; Membrane protein, integral; Membrane protein, multi-pass; Receptor, GPCR P30680 rat T354-p 7652101 KSRLNETtETQRTLL activity, induced; intracellular localization; receptor internalization, altered signaling pathway regulation 21493671; 21795688 9 0 1 Dephosphorylation is initiated directly after receptor activation at or near the plasma membrane; leads to disruption of the ?-arrestin- GPCR complex +CDCA5 CDCA5 Cell cycle regulation Q96FF9 113130 11q13.1 human T48-p 472119 LPEIWPKtPSAAAVR molecular association, regulation cell cycle regulation H2A.1(DISRUPTS); SMC3(DISRUPTS) 21878504 1 3 4 +Psmb4 PSMB4 Cell cycle regulation; Cytoskeletal; EC 3.4.25.1; Protease; Proteasome complex P99026 19172 3 F2.1|3 40.74 cM mouse K201-ac 31910305 LLREVLEkQPVLSQT Proteasome protein degradation 24037710 0 3 0 +MACF1 ACF7 Actin-binding; Cytoskeletal; Motility/polarity/chemotaxis Q9UPN3 23499 1p34.3 human S7234-p 18507013 RAASPTRsSSSASQS intracellular localization cell motility, induced; cytoskeletal reorganization 21295697 1 2 1 inhibits localization along microtubules, alters organization of microtubules, regulates skin wound repair, SC migration +RAB12 RAB12 G protein; G protein, monomeric; G protein, monomeric, Rab Q6IQ22 201475 18p11.22 human S106-p 487152 AGQERFNsITSAYYR Ras autophagy, inhibited 34515301 6 19 13 +DVL3 DVL3 Motility/polarity/chemotaxis Q92997 1857 3q27.1 human S642-p 34668133 RSHHSLAsSLRSHHT Dsh_C intracellular localization 24993822 1 2 0 +POLR2A POLR2A EC 2.7.7.48; EC 2.7.7.6; Nucleotide Metabolism - purine; Nucleotide Metabolism - pyrimidine; Transcription initiation complex; Transferase P24928 5430 17p13.1 human R1810-m2 21329100 SYSPSSPrYTPQSPT RNA_pol_Rpb1_R molecular association, regulation transcription, induced; transcription, inhibited SMN(INDUCES); TDRD3(INDUCES) 21454787; 26700805 2 0 0 +INSR INSR EC 2.7.10.1; KINASE; Kinase, protein; Membrane protein, integral; Protein kinase, TK; Protein kinase, tyrosine (receptor) P06213 3643 19p13.2 human S1354-p 447679 SSLGFKRsYEEHIPY phosphorylation 7615833 2 4 0 No difference between non diabetic normal controls and NIDDM patients InsR phosphorylation at S1354 and T1375 +APEX1 APE1 DNA repair, damage; DNA-binding; Deoxyribonuclease; EC 4.2.99.18; Endoplasmic reticulum; Hydrolase; Lyase; Nuclear receptor co-regulator; Nucleolus; Transcription, coactivator/corepressor P27695 328 14q11.2 human K6-ac 459075 __MPKRGkKGAVAED molecular association, regulation; enzymatic activity, inhibited; enzymatic activity, induced DNA repair, induced; cell growth, induced; DNA repair, inhibited; transcription, inhibited XRCC1(INDUCES); XRCC1(DISRUPTS); LIG3(INDUCES) DNA(INDUCES) 14633989; 19934257; 27655688; 27994014 5 2 0 +Itpka ITPKA Carbohydrate Metabolism - inositol phosphate; EC 2.7.1.127; Kinase, lipid; Motility/polarity/chemotaxis P17105 81677 3q35 rat S119-p 4763186 LQQPRRLsTSSLSST molecular association, regulation neural plasticity; cytoskeletal reorganization EB3(DISRUPTS) 30466786 2 0 0 +STRAP STRAP Adaptor/scaffold; RNA splicing; UBIQUITIN LIGASE; Ubiquitin ligase Q9Y3F4 11171 12p12.3 human S179-p 11267003 ATMTEVKsLNFNMSV phosphorylation apoptosis, altered 19880523 2 0 0 negatively regulates ASK1 phosphorylation and ASK1-mediated signaling +ACBD4 ACBD4 Lipid-binding Q8NC06 79777 17q21.31 human S166-p 13206355 PKEPAPPsPESHSPR molecular association, regulation VAPB(INDUCES) 35019937 1 12 0 +SHC1 SHC1 iso2 Adaptor/scaffold; Apoptosis; Mitochondrial; Motility/polarity/chemotaxis P29353-2 6464 1q21.3 human S29-p 448791 EEWTRHGsFVNKPTR intracellular localization 16963224 4 35 16 after treatment with H2O2, the protein co-localizes with PKCD and co-translocates to the plasma membrane +NPAT NPAT Cell cycle regulation; Transcription regulation Q14207 4863 11q22.3 human T1270-p 2286400 SDLPVPRtPGSGAGE NPAT_C transcription, induced 10995387 1 2 1 multiple sites deletion mutant +Syk Syk EC 2.7.10.2; KINASE; Kinase, protein; Protein kinase, TK; Protein kinase, tyrosine (non-receptor) P48025 20963 13 A5|13 27.41 cM mouse Y130-p 447657 KENLIREyVKQTWNL molecular association, regulation; protein conformation FCER1G(DISRUPTS); ITGAM(DISRUPTS); Bcr(DISRUPTS) 18689684; 30051939; 31216232 7 3 0 +SRCIN1 SNIP Cytoskeletal Q9C0H9 80725 17q12 human Y264-p 456703 IYRKEPLyAAFPGSH AIP3 molecular association, regulation CSK(INDUCES) 23383002 1 5 97 +ATF7 ATF7 C2H2-type zinc finger protein; DNA-binding; Transcription factor P17544 11016 12q13.13 human T53-p 467516 IIADQTPtPTRFLKN protein degradation; molecular association, regulation; ubiquitination; phosphorylation transcription, induced; signaling pathway regulation TAF12(INDUCES) 18950637; 21858082 2 50 27 +NFE2L2 NRF2 DNA-binding; Transcription factor Q16236 4780 2q31.2 human S215-p 10292704 VETTMVPsPEAKLTE protein stabilization; molecular association, regulation; intracellular localization transcription, induced PIN1(INDUCES) 19668370; 34918396 2 7 0 inhibits ubiquitination; moderate effects observed only in NFE2L2-5A mutant +IRS2 IRS2 Adaptor/scaffold; Motility/polarity/chemotaxis Q9Y4H2 8660 13q34 human S306-p 3217341 EFRPRSKsQSSGSSA intracellular localization 34253290 3 39 26 disassociation of IRS2 from plasma membrane to cytosol; limits PM-associated PI3K and PIP3 synthesis +PPARA PPAR-alpha DNA-binding; Nuclear receptor; UBIQUITIN LIGASE Q07869 5465 22q13.31 human K185-sm 11539303 RSEKAKLkAEILTCE molecular association, regulation transcription, inhibited N-CoR1(INDUCES) 19955185 1 0 0 mammalian one-hybrid used for interaction +Mlkl MLKL KINASE; Kinase, protein; Protein kinase, Ser/Thr (non-receptor); Protein kinase, TKL Q9D2Y4 74568 8|8 E1 mouse S347-p 29611200 SKTQNSIsRTAKSTK PK_Tyr_Ser-Thr protein conformation 26024392 3 1 0 +Gabrg2 GABRG2 Channel, chloride; Channel, ligand-gated; Membrane protein, integral; Membrane protein, multi-pass; Transporter; Transporter, ion channel P22723 14406 11 A5|11 24.8 cM mouse K372-ub 11956711 SKDKDKKkKNPLLRM Neur_chan_memb protein degradation; receptor internalization, altered 19815531 1 0 0 regulation of the late endosomal/lysosomal trafficking of GABA receptors, regulation of synaptic transmission +Syn1 SYN1 Vesicle P09951 24949 Xq11 rat S551-p 448377 ARPPASPsPQRQAGP intracellular localization neural plasticity; exocytosis, inhibited; exocytosis, induced 19896987; 24743689; 24849359; 35723394 8 22 10 +SRSF11 SRSF11 RNA processing; RNA splicing; Spliceosome Q05519 9295 1p31.1 human S287-p 470248 KSRSRRRsKSPRRRR protein stabilization; ubiquitination; intracellular localization carcinogenesis, induced; RNA splicing, induced; cell motility, induced 36394206 1 1 0 +ERBB3 HER3 EC 2.7.10.1; KINASE; Kinase, protein; Membrane protein, integral; Oncoprotein; Protein kinase, TK; Protein kinase, tyrosine (receptor) P21860 2065 12q13.2 human Y1199-p 458099 DEDEEYEyMNRRRRH molecular association, regulation GRB2(INDUCES) 16729043 2 2 7 +HLA-B HLAB Immunoglobulin superfamily; Membrane protein, integral P01889 3106 6p21.33 human K335-ub 2793001 AAVMCRRkSSGGKGG receptor internalization, induced; protein degradation 18083706 1 0 0 MHC-I down-regulation of HLAB from the cell surface in cancer cells +MAP3K14 Nik EC 2.7.11.25; KINASE; Kinase, protein; Protein kinase, STE; Protein kinase, Ser/Thr (non-receptor) Q99558 9020 17q21.31 human S817-p 27259013 EKNPSKAsQSSRDTL protein degradation 20501937 2 1 0 IKKA-dependent destabilization of Nik +Rrad RRAD G protein; G protein, monomeric; G protein, monomeric, RGK NP_445790 83521 19p14 rat S25-p 4700219 ERDRRRGsTPWGPAP activity, induced 36215501 2 6 1 induces CaV1.2 activity +MAPT Tau iso8 ACETYLTRANSFERASE; Acetyltransferase; Cytoskeletal P10636-8 4137 17q21.31 human T181-p 447932 KTPPAPKtPPSSGEP molecular association, regulation; intracellular localization; phosphorylation cell growth, inhibited; autophagy, inhibited; cytoskeletal reorganization Tau iso8(INDUCES) 12414518; 15190058; 15664690; 33710538; 33967735; 35857446 107 36 23 +CORO1B coronin 1B Actin-binding; Motility/polarity/chemotaxis Q9BR76 57175 11q13.2 human S2-p 456131 ______MsFRKVVRQ molecular association, regulation cell motility, induced; cytoskeletal reorganization SMTNL2(INDUCES); SSH1(INDUCES); ARPC4(DISRUPTS); ARPC2(DISRUPTS); FKBPL(INDUCES); ARPC2(INDUCES) 16027158; 22619279; 25800056; 27592029; 33275893 7 0 0 +PTEN PTEN Carbohydrate Metabolism - inositol phosphate; EC 3.1.3.16; EC 3.1.3.48; EC 3.1.3.67; Motility/polarity/chemotaxis; Nuclear receptor co-regulator; PHOSPHATASE; Phosphatase, lipid; Tumor suppressor P60484 5728 10q23.31 human K402-ac 5041900 DQHTQITkV______ molecular association, regulation AIP1(INDUCES); DLG1(INDUCES) 18757404 1 0 0 +Ltk LTK EC 2.7.10.1; KINASE; Kinase, protein; Membrane protein, integral; Protein kinase, TK; Protein kinase, tyrosine (receptor) P08923 17005 2 E5|2 59.97 cM mouse Y672-p 472877 RDIYQASyYRKGGRT PK_Tyr_Ser-Thr carcinogenesis, induced; cell growth, induced; apoptosis, inhibited; signaling pathway regulation 34819663 1 3 16 induces AKT/ERK signaling pathway +Homer3 HOMER3 Adaptor/scaffold Q99JP6 26558 8|8 B3.3 mouse S120-p 3879113 ARLAREKsQDGGEFT molecular association, regulation GluR5(DISRUPTS) 26670047 2 6 24 circuit hyperexcitability in fragile X syndrome +HMGN1 HMGN1 DNA-binding; Nuclear receptor co-regulator P05114 3150 21q22.2 human K42-ac 458848 KPKKAAAkDKSSDKK HMG14_17 molecular association, regulation DNA(DISRUPTS) 10753971 1 0 0 +Brsk2 BRSK2 EC 2.7.11.1; EC 2.7.11.26; KINASE; Kinase, protein; Protein kinase, CAMK; Protein kinase, Ser/Thr (non-receptor) Q69Z98 75770 7|7 F5 mouse T464-p 4734913 PAGTPNPtPPSSPSV protein stabilization; enzymatic activity, inhibited; phosphorylation 23790753 1 6 5 inhibits axon branching (activated in BRSK2 18A mutant) +PIAS1 PIAS1 EC 6.3.2.-; Nuclear receptor co-regulator; SUMO LIGASE; SUMO conjugating system; SUMO ligase; Transcription, coactivator/corepressor O75925 8554 15q23 human S510-p 14160798 SPVSRTPsLPAVDTS sumoylation; enzymatic activity, induced 27256105 1 5 0 AMPK activation-induced ML3 SUMOylation +Oprd1 DOR-1 GPCR, family 1; Membrane protein, integral; Membrane protein, multi-pass; Receptor, GPCR P32300 18386 4 D2.3|4 64.78 cM mouse T358-p 449761 ATTRERVtACTPSDG receptor desensitization, altered; intracellular localization; receptor internalization, altered 10973976; 21220103 4 0 0 +Scg5 7B2 Chaperone; Secreted; Secreted, signal peptide P27682 25719 3q35 rat S139-p 457719 APDTAEFsREFQLDQ Secretogranin_V molecular association, regulation; activity, inhibited PCSK2(INDUCES) 16286464 1 5 0 +ARHGDIB RhoGDI beta Cell adhesion; G protein regulator, misc.; Motility/polarity/chemotaxis P52566 397 12p12.3 human Y153-p 7386101 YGPRPEEyEFLTPVE Rho_GDI molecular association, regulation; intracellular localization carcinogenesis, induced; cell motility, induced CDC42(DISRUPTS); RHOA(DISRUPTS); RAC1(DISRUPTS); SELPLG(INDUCES); RHOC(DISRUPTS); VAV1(INDUCES) 19321744; 24055812; 31075185; 32903764 4 1 23 +EGFR EGFR EC 2.7.10.1; KINASE; Kinase, protein; Membrane protein, integral; Oncoprotein; Protein kinase, TK; Protein kinase, tyrosine (receptor) P00533 1956 7p11.2 human T693-p 448054 RELVEPLtPSGEAPN receptor internalization, induced; molecular association, regulation; receptor recycling, induced; receptor internalization, altered; activity, inhibited; phosphorylation cell cycle regulation; signaling pathway regulation EGF(INDUCES) 16785992; 2115882; 2543683; 31395339; 34086370; 36184515; 7505275 19 53 30 regulates phosphorylation of downstream proteins and recycling of FGFR2 +Slc1a1 SLC1A1 Membrane protein, integral; Membrane protein, multi-pass; Transporter; Transporter, SLC family P51907 25550 1q52 rat S465-p 471076 TGIVEKLsKKELEQV activity, induced; intracellular localization 17062570; 19922365 2 0 0 +SLC9A3 NHE3 Membrane protein, integral; Membrane protein, multi-pass; Transporter; Transporter, SLC family P48764 6550 5p15.33 human S555-p 450899 AEGERRGsLAFIRSP receptor internalization, induced; activity, inhibited endocytosis, induced; signaling pathway regulation 23275470 27 5 4 Decrease cell surface expression; Gastrin-CCKBR signal transduction pathway +RB1 Rb Nuclear receptor co-regulator; Oncoprotein; Transcription, coactivator/corepressor; Tumor suppressor P06400 5925 13q14.2 human S838-p 14160962 ILVSIGEsFGTSEKF Rb_C molecular association, regulation cell cycle regulation; chromatin organization, altered; signaling pathway regulation E2F2(INDUCES); E2F1(INDUCES) DNA(DISRUPTS) 33219128 1 3 0 TCR signaling +ATF1 ATF-1 Transcription factor P18846 466 12q13.12 human S63-p 449762 GILARRPsYRKILKD pKID activity, induced; molecular association, regulation; protein conformation transcription, induced; transcription, altered; cell growth, altered PIN1(INDUCES) 12414794; 18794154; 28032861; 9687510 20 2 29 +CDKN1A p21Cip1 Cell cycle regulation; Inhibitor P38936 1026 6p21.2 human K16-ub 9897001 RQNPCGSkACRRLFG protein degradation; ubiquitination cell cycle regulation; carcinogenesis, induced; cell growth, induced 13678583; 17429006; 28446751 5 0 0 +LLGL1 LLGL1 Cell adhesion; Cytoskeletal; Motility/polarity/chemotaxis Q15334 3996 17p11.2 human S659-p 449916 RVKSLKKsLRQSFRR intracellular localization 34717957 2 10 7 +PIAS1 PIAS1 EC 6.3.2.-; Nuclear receptor co-regulator; SUMO LIGASE; SUMO conjugating system; SUMO ligase; Transcription, coactivator/corepressor O75925 8554 15q23 human K315-sm 55435688 SRALIKEkLTADPDS intracellular localization 32047143 1 3 0 +DMAP1 DMAP1 Transcription, coactivator/corepressor Q9NPF5 55929 1p34.1 human Y246-p 998916 EQVAEEEyLLQELRK DMAP1 methylation carcinogenesis, induced; apoptosis, inhibited; transcription, induced BUB3(DISRUPTS) DNA(DISRUPTS) 30553276 1 2 2 methylation inhibited/ blocked +HMGA1 HMGA1 DNA-binding P17096 3159 6p21.31 human T53-p 451515 KEPSEVPtPKRPRGR molecular association, regulation DNA(INDUCES) 17960875 4 55 35 Cdc2 phosphorylated HMGA1 has lower binding affinity than HIPK2 phosphorylated HMGA1. +RPL29 RPL29 Ribosomal; Translation P47914 6159 3p21.2 human K5-m2 35483238 ___MAKSkNHTTHNQ Ribosomal_L29e intracellular localization 29959229 1 1 0 Rpl29K5 methylation as a specific cellular biomarker for SetD7 activity; nuclear localization +WNK1 WNK1 EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, Other; Protein kinase, Ser/Thr (non-receptor) Q9H4A3 65125 12p13.33 human T60-p 450948 EYRRRRHtMDKDSRG activity, induced carcinogenesis, induced; cell growth, induced 16081417; 33744230 8 3 208 +SIRT6 SIRT6 DEACETYLASE; DEUBIQUITINASE; Deacetylase; EC 2.4.2.31; EC 3.5.1.-; Transferase Q8N6T7 51548 19p13.3 human S10-p 23144710 VNYAAGLsPYADKGK DNA repair, induced 27568560 2 8 1 +Actb ACTB Cytoskeletal; Motility/polarity/chemotaxis P60711 81822 12p11 rat S199-p 477773 ILTERGYsFTTTAER Actin intracellular localization cytoskeletal reorganization 31566433 1 9 19 +HIPK2 HIPK2 EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, CMGC; Protein kinase, Ser/Thr (non-receptor) Q9H2X6 28996 7q34 human S441-p 27732203 FFNRDTDsPYPLWRL Pkinase protein conformation 31519758 1 1 0 +Slc9a1 NHE1 Membrane protein, integral; Membrane protein, multi-pass; Motility/polarity/chemotaxis; Transporter; Transporter, SLC family P26431 24782 5q36 rat S776-p 475074 IRSKEPSsPGTDDVF activity, induced 19542484 7 4 0 +GLI1 GLI1 C2H2-type zinc finger protein; Oncoprotein; Transcription factor P08151 2735 12q13.3 human T394-p 1873647704 HGPDAHVtKRHRGDG protein stabilization; molecular association, regulation; intracellular localization carcinogenesis, induced; cell growth, induced; transcription, induced SUFU(DISRUPTS) 34052323 1 1 0 +HMGN1 HMGN1 DNA-binding; Nuclear receptor co-regulator P05114 3150 21q22.2 human S7-p 447788 _MPKRKVsSAEGAAK HMG14_17 intracellular localization 10739259 3 14 18 Phosphorylation facilitates localization to non-nuclear pools. +POLH POLH DNA repair, damage; EC 2.7.7.7; Transferase Q9Y253 5429 6p21.1 human K583-sm 1877365903 PVCEGVSkLEESSKA intracellular localization; enzymatic activity, inhibited 32350109 1 1 0 +CCKBR CCKBR GPCR, family 1; Membrane protein, integral; Membrane protein, multi-pass; Receptor, GPCR P32239 887 11p15.4 human T443-p 17825904 LSYTTIStLGPG___ molecular association, regulation ARRB1(INDUCES) 21156802 1 0 0 +Per1 PER1 Transcription factor O35973 18626 11|11 B3 mouse S661-p 451683 SSSYTASsASDDDKQ intracellular localization 15148313 1 0 0 +Cyp19a1 CYP19A1 EC 1.14.14.14; Lipid Metabolism - androgen and estrogen; Oxidoreductase P28649 13075 9 A5.3|9 29.49 cM mouse S118-p 4661903 HYISRFGsKRGLQCI p450 enzymatic activity, inhibited 18822378 1 0 0 +FLOT1 FLOT1 Adaptor/scaffold O75955 10211 6p21.33 human K195-ub 12252072 GIREAKAkQEKVSAQ protein stabilization; intracellular localization carcinogenesis, induced Snail1(INDUCES) 30631151 1 0 1 translocation of Flot-1 to the nucleus, suppresses proteasomal degradation, promotes epithelial-to-mesenchymal transition (EMT) high metastatic potential +VAMP7 VAMP7 Membrane protein, integral P51809 6845 Xq28 and Yq12 human Y45-p 27806317 SENNKLTySHGNYLF Longin molecular association, regulation; intracellular localization; protein conformation exocytosis, induced; cell growth, induced; cytoskeletal reorganization; signaling pathway regulation RAB3IP(INDUCES); RAB8A(INDUCES); Rhodopsin(INDUCES); SNAP-25(INDUCES); RAB11A(INDUCES); STX1A(INDUCES) 23471971; 30404838 2 1 0 SRc and insulin/IGF-1 dependent signaling pathway. Increase axonal growth in hippocampal neurons +ELAVL1 HuR RNA-binding Q15717 1994 19p13.2 human S242-p 5594500 NVPGNASsGWCIFIY molecular association, regulation; intracellular localization cell cycle regulation; cell growth, altered RNA(DISRUPTS) 18948743 2 0 0 ELAVL1 S242A mutation promotes interaction of the protein with cyclin A2 and cyclin B1 mRNA and cell proliferation +WEE1 Wee1 EC 2.7.10.2; KINASE; Kinase, protein; Protein kinase, Other; Protein kinase, Ser/Thr (non-receptor); Protein kinase, tyrosine (non-receptor) P30291 7465 11p15.4 human S642-p 455381 KKMNRSVsLTIY___ intracellular localization; enzymatic activity, inhibited; enzymatic activity, induced cell cycle regulation; cell growth, induced 14-3-3 theta(INDUCES) 15964826; 33796458; 34168048; 34570813 12 1 1 +MEF2D MEF2D DNA-binding; Transcription factor Q14814 4209 1q22 human S444-p 449407 SIKSEPVsPSRERSP sumoylation; molecular association, regulation; acetylation; intracellular localization; activity, inhibited neural plasticity; transcription, inhibited p300(DISRUPTS); HDAC5(INDUCES) DNA(DISRUPTS) 16356933; 30523159; 30699340; 37458356 7 19 26 +Ptpn6 SHP-1 EC 3.1.3.48; Motility/polarity/chemotaxis; PHOSPHATASE; Protein phosphatase, tyrosine (non-receptor) P29351 15170 6 F2|6 59.17 cM mouse Y536-p 448506 QKGQESEyGNITYPP molecular association, regulation; enzymatic activity, induced STAT5A(INDUCES) 17575265; 20858858; 22210881; 28811476 20 24 637 +PHB1 PHB Apoptosis; Cell cycle regulation; Chaperone; Mitochondrial; Motility/polarity/chemotaxis; Nuclear receptor co-regulator; Oncoprotein; Transcription, coactivator/corepressor P35232 5245 17q21.33 human Y114-p 6374001 FTSIGEDyDERVLPS Band_7 O-GlcNAc glycosylation; molecular association, regulation; phosphorylation cell differentiation, induced; transcription, altered SHP-1(INDUCES) 19238206; 19497338; 22124450 6 1 0 regulation of MAPK/ERK and PI3K/AKT signaling during adipogenesis, regulates phosphorylation of ERK, AKT and CREB; attenuates phosphorylation of Akt T308 and S473 +Map3k7 TAK1 iso3 EC 2.7.11.25; KINASE; Kinase, protein; Protein kinase, Ser/Thr (non-receptor); Protein kinase, TKL Q923A8 26409 4|4 A5 mouse T184-p 454876 GTACDIQtHMTNNKG PK_Tyr_Ser-Thr activity, induced; molecular association, regulation apoptosis, induced; signaling pathway regulation TAB2(INDUCES); TRAF6(INDUCES) 30626936 20 0 0 Phosphorylation of JNK, p38 and IkB (subsequent degradation) +Dync1i2 DYNC1I2 Microtubule-binding; Motility/polarity/chemotaxis; Motor Q62871 116659 3q22 rat S90-p 4033130 PPPMSPSsKSVSTPS molecular association, regulation; intracellular localization endocytosis, induced; cell motility, induced PXN(DISRUPTS); FAK(DISRUPTS); dynactin 1(DISRUPTS) 22553211 3 11 2 regulates focal adhesion turnover and stability; interaction between paxillin and DYNC1I2 facilitates endocytosis +RAB11A RAB11A G protein; G protein, monomeric; G protein, monomeric, Rab; Motility/polarity/chemotaxis P62491 8766 15q22.31 human S177-p 22826101 TEIYRIVsQKQMSDR activity, inhibited endocytosis, inhibited 22188018; 28696251 2 1 0 transient BK current AUC through Rab11A S177; S177D mutant led to retained transferrin in the endocytic recycling compartment +PRKDC DNAPK DNA repair, damage; EC 2.7.11.1; KINASE; Kinase, protein; Nucleolus; Protein kinase, Ser/Thr (non-receptor); Protein kinase, atypical P78527 5591 8q11.21 human S2624-p 473575 QTRTQEGsLSARWPV DNAPKcs_CC5 molecular association, regulation; protein conformation DNA repair, induced DNA(DISRUPTS) 24687855 2 6 0 cell survival induced, induces removal of cisplatin adducts from DNA, induces end processing +CTNNB1 CTNNB1 Actin-binding; Cell adhesion; Motility/polarity/chemotaxis; Nuclear receptor co-regulator; Oncoprotein; Transcription factor P35222 1499 3p22.1 human Y654-p 447585 RNEGVATyAAAVLFR activity, induced; protein stabilization; molecular association, regulation; intracellular localization cell growth, induced; transcription, induced; cytoskeletal reorganization; signaling pathway regulation; transcription, altered; cell growth, altered LEF-1(DISRUPTS); TBN(INDUCES); Src(INDUCES); CDH1(DISRUPTS); SMAD2(INDUCES); HIF1A(INDUCES); axin 1(DISRUPTS); CDH5(DISRUPTS); TCF4(INDUCES); Met(DISRUPTS) 12740122; 16952352; 17318191; 19104148; 20840866; 21423209; 23246962; 29311227; 34227224; 36064958; 37496925 32 2 20 +Snca SNCA Adaptor/scaffold O55042 20617 6 B3|6 29.15 cM mouse K6-ac 36294465 __MDVFMkGLSKAKE Synuclein molecular association, regulation; intracellular localization autophagy, induced; cytoskeletal reorganization SNCA(DISRUPTS) Other(DISRUPTS) 28257421 1 2 0 inhibits binding to lipid membranes +ERBB4 HER4 EC 2.7.10.1; KINASE; Kinase, protein; Membrane protein, integral; Protein kinase, TK; Protein kinase, tyrosine (receptor) Q15303 2066 2q34 human Y1162-p 2045347 RDKPKQEyLNPVEEN molecular association, regulation; enzymatic activity, induced cell motility, induced; cell growth, induced; apoptosis, inhibited GRB2(INDUCES); Arg(INDUCES); VAV2(INDUCES); VAV3(INDUCES) 16729043; 18721752; 19718025; 32561640 3 1 1 +GPHN gephyrin Adaptor/scaffold; EC 2.10.1.1; EC 2.7.7.75 Q9NQX3 10243 14q23.3-q24.1 human C212-pa 34668143 TEDKGVQcEEEEEEK molecular association, regulation; intracellular localization 25025157 1 1 0 clustering in neurons +Zfpm2 FOG2 C2H2-type zinc finger protein; Nuclear receptor co-regulator Q8CCH7 22762 15 B3.1|15 15.74 cM mouse K955-sm 1873213007 AAQLIATkEENKHLF molecular association, regulation transcription, induced GATA4(DISRUPTS) 23226341 1 0 0 desumoylation induces repression +Adcy6 ADCY6 Adenylyl cyclase; EC 4.6.1.1; Lyase; Membrane protein, integral; Membrane protein, multi-pass; Nucleotide Metabolism - purine; Transporter; Transporter, aquaporin family AAA40678 25289 7q36 rat S603-p 467270 WVPDRAFsRTKDSKA Adcy_cons_dom enzymatic activity, induced 11327830 1 0 0 +VDAC1 VDAC1 Channel, misc.; Membrane protein, integral; Mitochondrial P21796 7416 5q31.1 human S193-p 6406004 DGTEFGGsIYQKVNK Porin_3; TM protein conformation apoptosis, inhibited 19158487; 25545271 3 0 0 N-terminus conformation affected; S192A mutation results in cell death +CSF2RB CSF2RB Membrane protein, integral; Receptor, cytokine P32927 1439 22q12.3 human K477-ub 57676505 LRRKWEEkIPNPSKS protein degradation 24086733 1 0 0 +NANOG NANOG Cell development/differentiation; DNA-binding; Transcription factor Q9H9S0 79923 12p13.31 human T280-p 28070709 GLNVIQQtTRYFSTP protein stabilization; molecular association, regulation carcinogenesis, induced; cell motility, induced; cell growth, induced; transcription, induced p300(INDUCES); NANOG(INDUCES) DNA(INDUCES) 23708658 1 1 0 +FANCG FANCG DNA repair, damage O15287 2189 9p13.3 human S383-p 454239 DSSEPRFsPPPSPPG activity, induced 15367677 2 0 0 +OSBP2 OSBP2 Q969R2 23762 22q12.2 human S768-p 15721697 HSSPSSPsSDGKQKT Oxysterol_BP molecular association, regulation; protein conformation signaling pathway regulation Vimentin(INDUCES) 30925160 1 2 1 +NDUFV2 NDUFV2 EC 1.6.5.3; EC 1.6.99.3; Energy Metabolism - oxidative phosphorylation; Mitochondrial; Oxidoreductase P19404 4729 18p11.22 human Y193-p 25682900 VQINDNYyEDLTAKD 2Fe-2S_thioredx enzymatic activity, induced apoptosis, inhibited 22823520 1 0 0 +FPR1 FPR1 GPCR, family 1; Membrane protein, integral; Membrane protein, multi-pass; Motility/polarity/chemotaxis; Receptor, GPCR P21462 2357 19q13.41 human S338-p 450845 TSDTATNsTLPSAEV molecular association, regulation; receptor desensitization, altered; receptor internalization, altered ARRB2(INDUCES) 10514456; 16622009 2 0 0 +HELB helicase B DNA replication; EC 3.6.4.12; Helicase Q8NG08 92797 12q14.3|12q human S967-p 451682 APPADFPsPRKSSGD intracellular localization 15146062 1 27 13 +PHACTR3 PHACTR3 Protein phosphatase, regulatory subunit Q96KR7 116154 20q13.32-q13.33 human S318-p 18944907 QGRESKGsPKKRLDV intracellular localization neural plasticity; cytoskeletal reorganization 21487013 1 0 0 supports axonal elongation +NFE2 NF-E2 Cytoskeletal; DNA-binding; Transcription factor Q16621 4778 12q13.13 human K108-ub 11489908 NMAIPVSkPLSLSGL protein degradation; ubiquitination transcription, inhibited 19966288 1 0 0 +HAS2 HAS2 EC 2.4.1.212; Membrane protein, integral; Membrane protein, multi-pass; Motility/polarity/chemotaxis; Transferase Q92819 3037 8q24.13 human T110-p 18122801 LQSVKRLtYPGIKVV enzymatic activity, inhibited cell motility, altered; cell adhesion, altered 21228273 2 0 1 +SEPTIN7 SEPT7 Cell cycle regulation; Cytoskeletal; Hydrolase Q16181 989 7p14.2 human Y319-p 450712 RKLAAVTyNGVDNNK Septin molecular association, regulation SEPT11(DISRUPTS); SEPT8(INDUCES); SEPT9(DISRUPTS); SEPT6(DISRUPTS) 21767235 1 16 461 +Ghr GH receptor Membrane protein, integral; Receptor, cytokine P16310 25235 2q16 rat Y333-p 455507 ILGIHDNyKPDFYND GHBP molecular association, regulation; phosphorylation transcription, altered SOCS3(INDUCES) 10585430; 12766799 3 0 0 JAK2 phosphorylation +ZNF322 ZNF322A C2H2-type zinc finger protein; Transcription factor Q6U7Q0 79692 6p22.2 human S391-p 31086030 SEKGLELsPPHASEA protein degradation; ubiquitination transcription, inhibited 28581525 1 1 0 +NCOA3 SRC-3 ACETYLTRANSFERASE; Acetyltransferase; EC 2.3.1.48; Motility/polarity/chemotaxis; Nuclear receptor co-regulator; Transcription, coactivator/corepressor Q9Y6Q9 8202 20q13.12 human T1114-p 4252804 KAGLYGQtYPAQGPP protein stabilization; molecular association, regulation PSMA3(DISRUPTS) 18313384 1 0 0 some subset of these 8 residues +RACK1 RACK1 Adaptor/scaffold; G protein; G protein, heterotrimeric; G protein, heterotrimeric beta; Motility/polarity/chemotaxis; Nuclear receptor co-regulator P63244 10399 5q35.3 human K225-ub 12407451 LWDLNEGkHLYTLDG WD40 protein degradation carcinogenesis, induced 33323973 1 1 3 +PIM1 Pim1 iso2 EC 2.7.11.1; KINASE; Kinase, protein; Oncoprotein; Protein kinase, CAMK; Protein kinase, Ser/Thr (non-receptor) P11309-2 5292 6p21.2 human S65-p 1190526800 HSHSPRHsLRHSPGS protein stabilization; enzymatic activity, induced cell growth, induced; apoptosis, inhibited 30017192 1 0 0 +APTX APTX C2H2-type zinc finger protein; DNA repair, damage; EC 3.-.-.-; Nucleolus; Phosphatase (non-protein); RNA-binding Q7Z2E3 54840 9p21.1 human T125-p 9397200 AKNPGLEtHRKRKRS molecular association, regulation; intracellular localization apoptosis, altered KPNA1(DISRUPTS) 19561170 1 0 0 +Scnn1g ENaC-gamma Channel, sodium; Membrane protein, integral; Membrane protein, multi-pass; Transporter, ion channel P37091 24768 1q36 rat K10-ub 486252 PGEKIKAkIKKNLPV receptor recycling, inhibited; protein degradation; intracellular localization 9351815 1 0 0 +ACTR2 ARP2 Actin-binding; Cytoskeletal; Motility/polarity/chemotaxis P61160 10097 2p14 human Y202-p 38546300 KLLLLRGyAFNHSAD Actin cytoskeletal reorganization 25601402 1 0 0 EGF-increased actin filament assembly membrane protrusion, actin nucleation activity +HOXA10 HOXA10 DNA-binding; Transcription factor P31260 3206 7p15.2 human K164-sm 1873286912 CSFAQNIkEESSYCL protein degradation; molecular association, regulation; acetylation transcription, inhibited; cell adhesion, inhibited DNA(DISRUPTS) 29018572 1 0 0 Inhibits acetylation +SHC1 SHC1 Adaptor/scaffold; Apoptosis; Mitochondrial; Motility/polarity/chemotaxis P29353 6464 1q21.3 human S36-p 448508 TPPEELPsPSASSLG molecular association, regulation; intracellular localization; phosphorylation carcinogenesis, induced; apoptosis, induced MIA(DISRUPTS) 14749389; 15837797; 16794602; 17431427; 31941526 20 1 0 induces breast cancer cell survival, inhibits AMPK, SFK, AKT phosphorylation +TTK TTK Cancer Testis Antigen (CTA); EC 2.7.12.1; KINASE; Kinase, protein; Protein kinase, Other; Protein kinase, dual-specificity (non-receptor) P33981 7272 6q14.1 human S37-p 2846500 EDLTDELsLNKISAD intracellular localization; enzymatic activity, induced cell cycle regulation 25265012; 26119734; 36395767 8 9 0 autophosphorylation of this site is required for release TTK from kinetochore; causes decreased kinetochore localization of BubR1 and Mad2. +ABL1 Abl EC 2.7.10.2; KINASE; Kinase, protein; Oncoprotein; Protein kinase, TK; Protein kinase, tyrosine (non-receptor) P00519 25 9q34.12 human K711-ac 461004 EGGGSSSkRFLRSCS intracellular localization cell differentiation, induced 16648821 1 0 0 +PARP10 PARP10 EC 2.4.2.30; Nucleolus; Transferase Q53GL7 84875 8q24.3 human T601-p 31905435 EVRELLAtLEGLDLD enzymatic activity, inhibited carcinogenesis, induced; cell growth, induced 32060423 1 1 0 Induce HCC cell proliferation +XRCC4 XRCC4 DNA repair, damage Q13426 7518 5q14.2 human S328-p 3195419 LETLRNSsPEDLFDE XRCC4 ubiquitination; intracellular localization DNA repair, induced; DNA repair, inhibited DNA(INDUCES) 25166505; 26774286 3 10 1 recruitment to DNA damage sites; prevents Anaphase bridge formation, prevents chromosome instability +CSF2RB CSF2RB Membrane protein, integral; Receptor, cytokine P32927 1439 22q12.3 human K483-ub 57676504 EKIPNPSkSHLFQNG protein degradation 24086733 1 0 0 +Dusp1 DUSP1 EC 3.1.3.16; EC 3.1.3.48; Motility/polarity/chemotaxis; PHOSPHATASE; Protein phosphatase, dual-specificity P28563 19252 17 A3.3|17 13.28 cM mouse K57-ac 2884406 TIVRRRAkGAMGLEH Rhodanese molecular association, regulation signaling pathway regulation P38A(INDUCES) 18504304 1 0 0 inhibits phosphorylation of p38 and MAPK signaling +ETV1 ETV1 DNA-binding; Oncoprotein; Transcription factor P50549 2115 7p21.2 human S334-p 3059601 PTYQRRGsLQLWQFL molecular association, regulation transcription, induced DNA(DISRUPTS) 12213813; 25866208 2 1 0 +Cbx5 HP1 alpha Transcription, coactivator/corepressor Q61686 12419 15|15 F3 mouse S13-p 476164 KRTADSSsSEDEEEY molecular association, regulation H3(INDUCES) DNA(INDUCES) 21245376 1 34 2 important for chromosomal stability +HSP90AA1 HSP90A Chaperone; Heat shock protein P07900 3320 14q32.31 human Y313-p 465173 NEEYGEFyKSLTNDW HSP90 molecular association, regulation AHSA1(INDUCES) 22727666 1 2 8 +DPYSL3 CRMP-4 Hydrolase Q14195 1809 5q32 human S522-p 458800 PAGSARGsPTRPNPP cell motility, altered 16611631 5 52 7 increases axon length +Itpr2 IP3R2 Channel, calcium; Channel, ligand-gated; Membrane protein, integral; Membrane protein, multi-pass Q9Z329 16439 6 G3|6 77.7 cM mouse S937-p 468039 QMVLSRGsIFPVSVP activity, induced 19608738 1 7 0 +GTF2B GTF2B ACETYLTRANSFERASE; Acetyltransferase; Nuclear receptor co-regulator; Transcription factor Q00403 2959 1p22.2 human S65-p 13823200 DKATKDPsRVGDSQN molecular association, regulation transcription, induced CSTF2(INDUCES) 20226668 1 0 1 +Mef2c MEF2C DNA-binding; Transcription factor Q8CFN5 17260 13 C3|13 43.68 cM mouse S240-p 456976 NKNIQAKsPPPMNLG molecular association, regulation PIN1(INDUCES) 20801874 1 19 0 Pin1 binding decreases MEF2C stability and its transcriptional activity +CCR5 CCR5 GPCR, family 1; Membrane protein, integral; Membrane protein, multi-pass; Motility/polarity/chemotaxis; Receptor, GPCR; Receptor, cytokine P51681 1234 3p21.31 human S336-p 449901 QEAPERAsSVYTRST molecular association, regulation; receptor desensitization, altered; receptor internalization, altered; activity, inhibited ARRB1(INDUCES); ARRB2(INDUCES) 10085131; 11782464; 12065593 4 0 0 +Foxk2 FOXK2 DNA-binding; Transcription factor Q3UCQ1 68837 11|11 E2 mouse S190-p 36124957 HLISPLPsPTGTISA intracellular localization carcinogenesis, induced; transcription, altered 35412849 1 3 0 +NFATC1 NFAT2 DNA-binding; Transcription factor O95644 4772 18q23 human S257-p 40512526 SWLGARSsRPASPCN activity, induced carcinogenesis, induced; cell motility, induced; transcription, induced 31730483 5 3 0 multiple sites mutatnt +Spry4 SPRY4 Adaptor/scaffold; Inhibitor D3ZJA3 291610 18p11 rat Y53-p 454877 TSHVENDyIDNPSLA phosphorylation cell growth, inhibited; signaling pathway regulation 36818650 2 16 139 inhibits ERK phosphorylation, regulates Trk to Erk1/2 signaling pathway +PGK1 PGK1 Carbohydrate Metabolism - glycolysis and gluconeogenesis; EC 2.7.2.3; KINASE; Kinase, other P00558 5230 Xq21.1 human S203-p 468410 YFAKALEsPERPFLA PGK intracellular localization; protein conformation carcinogenesis, induced 26942675; 31578148 3 83 11 +NCOA3 SRC-3 ACETYLTRANSFERASE; Acetyltransferase; EC 2.3.1.48; Motility/polarity/chemotaxis; Nuclear receptor co-regulator; Transcription, coactivator/corepressor Q9Y6Q9 8202 20q13.12 human K786-sm 3817002 QEKDPKIkTETSEEG DUF4927 transcription, inhibited 16760465 1 1 0 +Gucy1b1 GUCY1B1 EC 4.6.1.2; Guanylyl cyclase; Lyase; Nucleotide Metabolism - purine; Receptor, misc. O54865 54195 3|3 E3 mouse Y192-p 469612 ESKEEDFyEDLDRFE molecular association, regulation; intracellular localization Fyn(INDUCES) 23602477 3 0 0 +HDAC1 HDAC1 DEACETYLASE; Deacetylase; EC 3.5.1.98; Hydrolase; Nuclear receptor co-regulator Q13547 3065 1p35.2-p35.1 human K444-sm 2407421 FKKAKRVkTEDEKEK cell cycle regulation; transcription, inhibited 11960997 3 1 0 +RELA NFkB-p65 DNA-binding; Nuclear receptor co-regulator; Transcription factor Q04206 5970 11q13.1 human K37-m1 12486801 RGMRFRYkCEGRSAG RHD_DNA_bind molecular association, regulation transcription, induced DNA(INDUCES) 19864627 1 0 0 +Esrp2 RBM35B RNA-binding Q8K0G8 77411 8|8 D3 mouse K534-ub 52473103 RCHKKMMkERYVEVV RRM_1 carcinogenesis, inhibited; RNA splicing, induced; cell growth, inhibited 26522722 1 0 0 +MED1 MED1 Nuclear receptor co-regulator; Transcription, coactivator/corepressor Q15648 5469 17q12 human T1032-p 458308 SSSNRPFtPPTSTGG activity, induced; molecular association, regulation; protein stabilization; receptor recycling, induced; intracellular localization carcinogenesis, induced; cell growth, induced; transcription, induced MED31(INDUCES) DNA(INDUCES) 16314496; 23850489; 35394046 4 8 2 +LAMTOR4 LAMTOR4 Q0VGL1 389541 7q22.1 human S67-p 1868827201 NVPFKRLsVVFGEHT molecular association, regulation LAMTOR1(DISRUPTS) 31314152 1 1 0 when in complex with HBXIP - dimer HBXIP-LAMTOR4 +AFP AFP Secreted; Secreted, signal peptide P02771 174 4q13.3 human K211-ac 1879738501 TKAATVTkELRESSL ubiquitination carcinogenesis, induced; cell motility, induced; cell growth, induced; apoptosis, inhibited 31811908 1 1 0 inhibits ubiquitination, promotes the migration and invasion +MAPKAP1 Sin1 Adaptor/scaffold Q9BPZ7 79109 9q33.3 human T86-p 3253548 GIRRRSNtAQRLERL SIN1 activity, induced 26235620 3 4 10 +Rab7a Rab7 G protein; G protein, monomeric; G protein, monomeric, Rab P51150 19349 6 D1|6 39.13 cM mouse S72-p 468547 AGQERFQsLGVAFYR Ras molecular association, regulation; intracellular localization CHML(DISRUPTS); CHM(DISRUPTS); RILP(DISRUPTS) 26038114 7 50 21 endo-lysosomal localization S72A mutant, S72D or S72E mutant were diffusely localized +UBR5 UBR5 EC 6.3.2.-; EC 6.3.2.19; Ligase; Nuclear receptor co-regulator; UBIQUITIN LIGASE; Ubiquitin conjugating system; Ubiquitin ligase O95071 51366 8q22.3 human S1227-p 21214703 DCKLKRTsPTAYCDC translation, inhibited 28559278 1 4 0 translational repression of TRAF3 mRNA +H4C1 H4 DNA-binding P62805 8359 6p22.2 human K12-ac 459013 KGGKGLGkGGAKRHR molecular association, regulation; methylation cell cycle regulation; carcinogenesis, induced; cell growth, inhibited; apoptosis, induced; transcription, induced; transcription, altered; DNA repair, induced; chromatin organization, altered; cell differentiation, induced TBN(INDUCES); polybromo 1(INDUCES); BRDT(INDUCES); CGI-09(INDUCES); BRD7(INDUCES); PUS1(INDUCES); THOC4(INDUCES); SETD8(DISRUPTS); TAF4(INDUCES); BRD2(INDUCES) DNA(INDUCES); DNA(DISRUPTS) 11387442; 15456746; 17498659; 17530637; 17560255; 18179771; 18418072; 18628788; 18985155; 20043883; 20048151; 20368734; 20709061; 20720004; 21047799; 21726812; 23287868; 23653357; 23970329; 25788266; 25806092; 36961817 93 25 531 estrogen induced transcription; decline of histone marks was more notable in H4K5ac and H4K12ac; aberrant histone acetylation and chromatin compaction in sperm of subfertile men +Ksr1 KSR KINASE; Kinase, protein; Protein kinase, Ser/Thr (non-receptor); Protein kinase, TKL Q61097 16706 11 B5|11 46.74 cM mouse Y552-p 22639616 KASQTSVyLQEWDIP phosphorylation 23993095 1 0 0 induces phosphorylation of ERK +NACA NACA Motility/polarity/chemotaxis; Transcription, coactivator/corepressor E9PAV3 4666 12q13.3 human S1906-p 454238 PELEEQDsTQATTQQ activity, induced; intracellular localization transcription, induced 15299025 2 1 0 +Shc1 SHC1 Adaptor/scaffold; Apoptosis; Mitochondrial; Motility/polarity/chemotaxis P98083 20416 3 F1|3 39.11 cM mouse S139-p 448791 EEWTRHGsFVNKPTR molecular association, regulation PTP-PEST(INDUCES) 12052829 4 35 16 binding to PTPN12 down-regulates insulin-induced ERK activation +OPA1 OPA1 Apoptosis; EC 3.6.5.5; Hydrolase; Membrane protein, integral; Mitochondrial O60313 4976 3q29 human K931-ac 31068001 KIKLLTGkRVQLAED OPA1_C enzymatic activity, inhibited; activity, inhibited 24344202; 33857259 2 2 0 acetyl-mimic at K931, which inhibits OPA1 functionK931, which inhibits OPA1 function, allows for mitochondrial fragmentation and virus production.; regulation of mitochondrial dynamics, morphology and function +Cdkn1a p21Cip1 Cell cycle regulation; Inhibitor Q64315 114851 rat T145-p 447837 QGRKRRQtSLTDFYH cell cycle regulation; carcinogenesis, induced 34569407 20 0 0 +Kcnj3 GIRK1 Channel, potassium; Membrane protein, integral; Membrane protein, multi-pass P63251 50599 3q21 rat S185-p 450683 GCMFIKMsQPKKRAE IRK activity, inhibited 14732702 1 0 0 inhibition of channel open-state probability +Ppargc1a PGC-1 alpha Nuclear receptor co-regulator; Transcription, coactivator/corepressor O70343 19017 5|5 C1 mouse S572-p 6421246 RSRSRSFsRHRSCSR molecular association, regulation; activity, inhibited transcription, inhibited; signaling pathway regulation HNF4 alpha(DISRUPTS) 21646374 1 0 0 Gluconeogenic pathway; Regulation of gluconeogenesis +PRKACA PKACA EC 2.7.11.11; KINASE; Kinase, protein; Protein kinase, AGC; Protein kinase, Ser/Thr (non-receptor) P17612 5566 19p13.12 human S339-p 449886 EEEEIRVsINEKCGK protein stabilization; protein processing; protein conformation; phosphorylation; enzymatic activity, induced 15481030; 22154087; 22493239 13 36 28 optimal enzymatic activity; solublity of C-sub unit, phosphorylation of T198 site +Tp53 p53 Activator; DNA-binding; Motility/polarity/chemotaxis; Nuclear receptor co-regulator; Transcription factor; Tumor suppressor P10361 24842 10q24 rat S390-p 447535 IKKVGPDsD______ apoptosis, induced 35917315 118 15 0 +CDC25B CDC25B EC 3.1.3.48; Motility/polarity/chemotaxis; Nuclear receptor co-regulator; PHOSPHATASE; Protein phosphatase, dual-specificity P30305 994 20p13 human S50-p 20503402 PVRAAASsPVTTLTQ phosphorylation 21640712 1 3 0 induces phosphorylation at other sites by PLK1 +Aqp2 AQP2 Channel, misc.; Membrane protein, integral; Membrane protein, multi-pass; Transporter; Transporter, aquaporin family P56402 11827 15 F1|15 56.13 cM mouse S261-p 464644 RQSVELHsPQSLPRG ubiquitination; intracellular localization 19966308; 29212817 38 9 0 +Nlrp3 NLRP3 Inhibitor Q8R4B8 216799 11|11 B1.3 mouse S330-p 409465602 RGDILLSsLIRKKLL NACHT phosphorylation transcription, induced; signaling pathway regulation 33087357 2 1 0 regulation of AKT-STAT1 phosphorylation and AKT-STAT1-PRDX1-NF-kB signaling during inflammation +MAVS MAVS Adaptor/scaffold; Membrane protein, integral Q7Z434 57506 20p13 human R41-me 1883504204 LTARDQDrLRATCTL activity, inhibited 36028484 1 1 0 PRMT9-mediated MAVS methylation inhibits MAVS aggregation and activation. +ELK4 ELK4 DNA-binding; Transcription, coactivator/corepressor P28324 2005 1q32.1 human T194-p 41290001 SVIKFVTtPSKKPPV cell growth, induced; transcription, induced 26028036 1 1 0 +ESCO2 ESCO2 ACETYLTRANSFERASE; Acetyltransferase; DNA replication; EC 2.3.1.- Q56NI9 157570 8p21.1 human T233-p 1881957104 NEPSLGRtQKSKSEV molecular association, regulation; intracellular localization carcinogenesis, induced; DNA repair, induced MDC1(INDUCES) 37377435 1 0 0 +TPX2 TPX2 Cell cycle regulation; Microtubule-binding Q9ULW0 22974 20q11.21 human S121-p 459996 PAQPQRRsLRLSAQK molecular association, regulation cell cycle regulation CLASP1(INDUCES) 26240182 3 17 33 required for normal spindle length +IL9R IL9R Membrane protein, integral; Receptor, cytokine Q01113 3581 Xq28 and Yq12 human Y407-p 10306403 WRVQTLAyLPQEDWA apoptosis, inhibited; cell growth, altered DNA(INDUCES) 8756628 1 0 0 required for IL9-induced binding to GRR oligonucleotide complex containing activated STAT1-alpha, STAT3 and STAT5. +Csf1r CSFR EC 2.7.10.1; KINASE; Kinase, protein; Membrane protein, integral; Oncoprotein; Protein kinase, TK; Protein kinase, tyrosine (receptor) P09581 12978 18 E1|18 34.41 cM mouse Y807-p 448365 DIMNDSNyVVKGNAR PK_Tyr_Ser-Thr molecular association, regulation; enzymatic activity, induced cell cycle regulation; apoptosis, altered; cell differentiation, altered; apoptosis, inhibited; transcription, induced; transcription, altered; cell growth, altered PLCG1(INDUCES) 10727433; 11739737; 1652061; 17420255; 18519746; 7545432; 8981370; 9312046 21 2 12 +TAB1 TAB1 Activator; Motility/polarity/chemotaxis Q15750 10454 22q13.1 human S453-p 22869803 TNTHTQSsSSSSDGG intracellular localization; phosphorylation; enzymatic activity, induced transcription, inhibited 22216226 1 0 0 TAB1 induce p38 MAPK phosphorylation and mRNA destabilization, induces p38 MAPK activation. TAB1 and p38MAPK mutually control eachother's phosphorylation status, activity and intracellular localization. +MALT1 MALT1 Adaptor/scaffold; Apoptosis; EC 3.4.22.-; Ligase; Nuclear export; Protease; UBIQUITIN LIGASE; Ubiquitin conjugating system Q9UDY8 10892 18q21.32 human K644-ub 2134705 LDLDIDPkDANKGTP MALT1_Ig protein degradation; protein stabilization; molecular association, regulation; protein processing; protein conformation; enzymatic activity, induced carcinogenesis, induced; cell growth, induced; transcription, induced IKKA(INDUCES); MALT1(INDUCES) 17948050; 23416615; 28052131; 31980531 4 1 0 MALT1 auto-cleavage at R149, MALT1 oligomerization; conformational changes in the loop connecting K644 to Y657 and the active site; size exclusion chromatography, induces NF-kB, IL-2 activation; activation of NF-kB pathway and IL-2 induction; monomeric ubiquitin binds to the Ig3 domain, transcription and secretion of IL-2 +PML PML Nucleolus; Oncoprotein; SUMO LIGASE; SUMO conjugating system; SUMO ligase; Transcription factor; Tumor suppressor; Ubiquitin conjugating system P29590 5371 15q24.1 human S518-p 465867 PSTSKAVsPPHLDGP DUF3583 protein degradation; molecular association, regulation; ubiquitination; phosphorylation carcinogenesis, induced; carcinogenesis, inhibited; cell growth, induced; cell motility, induced; apoptosis, inhibited; transcription, induced; signaling pathway regulation C/EBP-epsilon(INDUCES); PIN1(INDUCES); KLHL20(INDUCES) 17989716; 21840486; 25293974 3 61 25 induces S6K phosphorylation and hence mTOR/HIF signaling pathway; induces GLUT1 expression, induces HIF1 signaling and tumor hypoxia +G6PC1 G6PC1 Carbohydrate Metabolism - galactose; Carbohydrate Metabolism - glycolysis and gluconeogenesis; Carbohydrate Metabolism - starch and sucrose; EC 3.1.3.9; Endoplasmic reticulum; Membrane protein, integral; Membrane protein, multi-pass; Phosphatase (non-protein); Transporter; Transporter, SLC family P35575 2538 17q21.31 human H176-p 10296600 SRIYLAAhFPHQVVA PAP2 intracellular localization; enzymatic activity, induced 14718531; 9497333 3 0 0 phosphate acceptor in Glc-6-Pase-Beta, phosphoryl enzyme intermediate during Glc-6-P hydrolysis; phosphoryl acceptor, essential for G6Pase activity +TARDBP TDP-43 RNA-binding Q13148 23435 1p36.22 human K136-ac 9912116 EVLMVQVkKDLKTGH RRM_1 molecular association, regulation; intracellular localization RNA splicing, induced 35264561 1 0 1 K136 shows a nuclear droplet-like localization and reduced solubility and aggregation, and induces ubiquitylation and pathological phosphorylation, K136 mutant looses RNA binding and splicing activity. +MAX MAX DNA-binding; Transcription factor P61244 4149 14q23.3 human K66-ac 474517 SRAQILDkATEYIQY HLH molecular association, regulation; intracellular localization transcription, induced B-Myc(INDUCES) DNA(DISRUPTS) 17217336 1 2 0 +GFAP GFAP Cytoskeletal F1RR02 396562 pig T7-p 449617 _MERRRVtSAARRSY Filament_head cell cycle regulation 1379174 6 0 0 +SUV39H1 SUV39H1 Amino Acid Metabolism - lysine degradation; EC 2.1.1.43; METHYLTRANSFERASE; Methyltransferase; Methyltransferase, protein lysine O43463 6839 Xp11.23 human Y308-p 1871199002 LDYVEDVyTVDAAYY SET methylation; enzymatic activity, induced signaling pathway regulation 30833073 1 0 0 NRG-1/ErbB4 signaling +SEC63 SEC63 Endoplasmic reticulum; Membrane protein, integral; Membrane protein, multi-pass Q9UGP8 11231 6q21 human S574-p 27440601 EEVSDKGsDSEEEET molecular association, regulation SEC62(INDUCES) 23287549 1 1 0 +DLG1 DLG1 Adaptor/scaffold; Motility/polarity/chemotaxis Q12959 1739 3q29 human T657-p 22496705 KERARLKtVKFNSKT cell motility, induced 22027822 1 0 0 +GLI1 GLI1 C2H2-type zinc finger protein; Oncoprotein; Transcription factor P08151 2735 12q13.3 human S130-p 1877717204 HLSIGTMsPSLGFPA activity, induced; molecular association, regulation transcription, induced SUFU(DISRUPTS) 35831023 1 0 0 +INPPL1 SHIP-2 Carbohydrate Metabolism - inositol phosphate; EC 3.1.3.86; Motility/polarity/chemotaxis; Phosphatase, lipid O15357 3636 11q13.4 human K315-ub 12718515 PVQAFEVkLDVTLGD intracellular localization; enzymatic activity, induced 19880507 1 1 0 +CAD CAD Amino Acid Metabolism - alanine, aspartate and glutamate; EC 2.1.3.2; EC 3.5.2.3; EC 6.3.5.5; Hydrolase; KINASE; Ligase; Nucleotide Metabolism - pyrimidine; Transferase P27708 790 2p23.3 human T456-p 451248 KVYFLPItPHYVTQV activity, induced; intracellular localization; enzymatic activity, induced carcinogenesis, inhibited; cell growth, induced 15890648; 25472841; 31391321; 33771897 10 1 0 +ATXN3 ataxin-3 DEUBIQUITINASE; DNA repair, damage; EC 3.4.19.12; Protease; Transcription regulation; Ubiquitin-specific protease P54252 4287 14q32.12 human S256-p 479405 LRRAIQLsMQGSSRN UIM molecular association, regulation 17434145 2 1 0 ; phosphorylation of this site prevents protein aggregation; excessive aggregation of mutant S256A is inhibited by Hsp70 +BAIAP2 IRSp53 Actin-binding; Motility/polarity/chemotaxis Q9UQB8 10458 17q25.3 human S366-p 468035 KTLPRSSsMAAGLER molecular association, regulation cytoskeletal reorganization 14-3-3 theta(INDUCES) 21282462 2 44 26 regulates cell spreading +Irak2 IRAK2 KINASE; Kinase, protein; Protein kinase, Ser/Thr (non-receptor); Protein kinase, TKL Q8CFA1 108960 6 E3|6 52.82 cM mouse S136-p 18262493 VRPVKPRsLLDTGPI molecular association, regulation; intracellular localization signaling pathway regulation PHB(INDUCES); OPA1(INDUCES); TIMM50(INDUCES) 32778760 1 2 0 IL-1R?MyD88?IRAK2?PHB/OPA1 signaling pathway +EZH2 EZH2 EC 2.1.1.43; METHYLTRANSFERASE; Methyltransferase; Methyltransferase, protein lysine Q15910 2146 7q36.1 human S363-p 466986 GRLPNNSsRPSTPTI cell growth, inhibited; cell motility, inhibited 27494834 1 11 30 decreases H3K27 trimethylation +Gem GEM G protein; G protein, monomeric; G protein, monomeric, RGK P55041 14579 4 A1|4 5.34 cM mouse S286-p 1211200 NMAFKLKsKSCHDLS molecular association, regulation; intracellular localization 14-3-3 beta(DISRUPTS) 17605760 2 2 0 +PREX1 PREX1 GEF; GEF, Rac/Rho Q8TCU6 57580 20q13.13 human S436-p 2526571 KDRRRKLsTVPKCFL DEP molecular association, regulation; protein conformation; activity, inhibited 26797121; 32661198 2 4 2 regulates PREX1 binding to negatively charged phospholipids; inhibits GEF activity +Etv4 ETV4 DNA-binding P28322 18612 11 D|11 65.48 cM mouse K261-sm 3144815 PGAGVVIkQERTDFA ETS_PEA3_N protein degradation; ubiquitination transcription, induced; transcription, inhibited 18447755; 19307308 4 1 0 +APP APP Apoptosis; Cell surface; Membrane protein, integral; Receptor, misc.; Transcription factor P05067 351 21q21.3 human K687-ac 1876853302 GYEVHHQkLVFFAED Beta-APP molecular association, regulation 32207962 1 0 0 K887 Ac peptide reduces fibrillization of APP affects toxicity. It aggregates with the KKAc and shows higher toxicity than WT or K699 +PLD2 PLD2 EC 3.1.4.4; Lipid Metabolism - ether lipid; Lipid Metabolism - glycerophospholipid; Motility/polarity/chemotaxis; Phospholipase O14939 5338 17p13.2 human T566-p 15343400 FIQRWNFtKTTKAKY intracellular localization cytoskeletal reorganization 20733000 1 0 0 required for integrin-mediated cell spreading +Stx1a STX1A Membrane protein, integral; Vesicle P32851 116470 12q12 rat T21-p 451260 SDDDDDVtVTVDRDR endocytosis, altered; exocytosis, induced 33582301 2 1 0 +Mapt Tau ACETYLTRANSFERASE; Acetyltransferase; Cytoskeletal P10637 17762 11 67.79 cM|11 E1 mouse S491-p 447927 GERSGYSsPGSPGTP intracellular localization neural plasticity 24653715; 34453977 91 33 33 +MUS81 MUS81 Deoxyribonuclease; EC 3.1.22.-; Nucleolus Q96NY9 80198 11q13.1 human S87-p 31880574 RLQRHRTsGGDHAPD molecular association, regulation cell cycle regulation; DNA repair, altered SLX4(INDUCES) 29850896; 31114910; 37254810 3 1 0 +DEPTOR DEPTOR Apoptosis Q8TB45 64798 8q24.12 human S282-p 4723838 AVRRSSMsSCGSSGY protein degradation; molecular association, regulation carcinogenesis, induced; apoptosis, inhibited; signaling pathway regulation mTOR(DISRUPTS) 19446321 1 3 2 PI3K-Akt signaling +HSF1 HSF1 DNA-binding; Transcription factor Q00613 3297 8q24.3 human S326-p 455484 SSVDTLLsPTALIDS Vert_HS_TF activity, induced; molecular association, regulation; protein stabilization; intracellular localization; protein conformation; enzymatic activity, induced; phosphorylation cell cycle regulation; carcinogenesis, induced; carcinogenesis, altered; cell motility, induced; transcription, induced; signaling pathway regulation; transcription, altered; translation, altered; cell differentiation, induced; cell growth, induced; apoptosis, inhibited; cytoskeletal reorganization; translation, induced; transcription, inhibited CDK9(INDUCES); GTF2B(INDUCES); PIN1(INDUCES); SGOL2(INDUCES) RNA(INDUCES) 15760475; 22496356; 22768106; 24126052; 24469056; 24516381; 24746225; 24954509; 25679764; 25752395; 25963659; 26010766; 27354066; 27791982; 28415561; 28618124; 29088759; 30138434; 31614463; 31657478; 32959058; 33268814; 33407730; 33461973; 34922589; 35080342; 35201262; 35959699 48 25 13 +ARHGAP33 SNX26 GAP; GAP, Rac/Rho; Vesicle O14559 115703 19q13.12 human Y1169-p 476790 PTPPEPLyVNLALGP molecular association, regulation; phosphorylation cell growth, induced; cell differentiation, induced; transcription, induced; signaling pathway regulation SHP-2(INDUCES) 17664338 1 3 69 ERK5 MAP kinase pathway regulation,Cdc42/PAK signaling pathway, regulates phosphorylation of ERK5 and PAK +Brsk2 BRSK2 EC 2.7.11.1; EC 2.7.11.26; KINASE; Kinase, protein; Protein kinase, CAMK; Protein kinase, Ser/Thr (non-receptor) Q69Z98 75770 7|7 F5 mouse S440-p 4734885 PHPSPRGsPLPTPKG protein stabilization; enzymatic activity, inhibited; phosphorylation 23790753 1 4 1 inhibits axon branching (activated in BRSK2 18A mutant) +Hist1h2ail1 H3 DNA-binding Q6LED0 291159 17p11 rat K9-m2 459006 RTKQTARkSTGGKAP Histone transcription, inhibited 19476549 119 21 0 +ANKRD2 ANKRD2 Contractile Q9GZV1 26287 10q24.2 human S99-p 480101 QERVRKTsLDLRREI intracellular localization 28615162 2 6 8 91% of the pANKRD2 Ser99 was found in the Cyt fraction +CAV2 caveolin-2 Adaptor/scaffold; Motility/polarity/chemotaxis P51636 858 7q31.2 human S23-p 460671 DDSYSHHsGLEYADP Caveolin activity, induced 12743374 4 26 84 formation of caveolae +CEBPB C/EBP-beta DNA-binding; Motility/polarity/chemotaxis; Transcription factor P17676 1051 20q13.13 human K265-ac 458940 QVKSKAKkTVDKHSD molecular association, regulation transcription, inhibited DNA(DISRUPTS) 12574125 4 1 0 +MCL1 MCL1 Apoptosis; Channel, misc.; Inhibitor; Membrane protein, integral; Mitochondrial Q07820 4170 1q21.2 human T70-p 31857746 ASPPSTLtPDSRRVA protein degradation; protein stabilization; ubiquitination apoptosis, induced 27166195; 27738316 2 0 0 +STK39 STLK3 EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, STE; Protein kinase, Ser/Thr (non-receptor) Q9UEW8 27347 2q24.3 human S371-p 456506 VRRVPGSsGHLHKTE enzymatic activity, induced signaling pathway regulation 18270262; 21733846 20 20 1 +PTPRA PTPRA iso6 EC 3.1.3.48; Membrane protein, integral; Motility/polarity/chemotaxis; PHOSPHATASE; Receptor protein phosphatase, tyrosine P18433-2 5786 20p13 human Y789-p 447613 YIDAFSDyANFK___ molecular association, regulation; enzymatic activity, induced GRB2(INDUCES); Src(INDUCES) 10698938; 11689444; 8670803 17 85 2339 +Sipa1l1 SIPA1L1 GAP; GAP, Ras Q8C0T5 217692 12|12 D1 mouse S1328-p 3595500 SLGASTSsPRSGPGK protein degradation; molecular association, regulation PLK2(INDUCES) 18498738 1 2 0 +MAP3K2 MEKK2 EC 2.7.11.25; KINASE; Kinase, protein; Protein kinase, STE; Protein kinase, Ser/Thr (non-receptor) Q9Y2U5 10746 2q14.3 human K260-me 35480417 PIFEKFGkGGTYPRR molecular association, regulation; phosphorylation carcinogenesis, induced; cell growth, induced; signaling pathway regulation PPP2R2A(DISRUPTS) 24847881 1 0 0 induces MEK/ERK phosphorylation, Ras/Raf/MEK/ERK signaling pathway +Gabrb3 GABRB3 Channel, chloride; Channel, ligand-gated; Membrane protein, integral; Membrane protein, multi-pass; Transporter; Transporter, ion channel P63080 14402 7 B5|7 33.53 cM mouse S406-p 486453 GIQYRKQsMPKEGHG Neur_chan_memb activity, induced 17442679; 22531784 3 1 0 potentiated GABA currents; rapid insertion of GABA receptors at the cell surface and enhanced tonic current +Themis2 THEMIS2 Adaptor/scaffold; Cell adhesion; Motility/polarity/chemotaxis Q91YX0 230787 4|4 D2.3 mouse Y660-p 9415036 PDMDDHDyEEI____ molecular association, regulation LYN(INDUCES); GRB2(INDUCES) 20644716 1 2 21 promotes LPS-induced TNF production +Clec7a dectin-1 Membrane protein, integral Q6QLQ4 56644 6|6 F3 mouse Y3-p 50346900 _____MKyHSHIENL molecular association, regulation SHIP(INDUCES) 26416276 1 1 0 +Dll1 DLL1 Cell development/differentiation; Membrane protein, integral; Motility/polarity/chemotaxis Q61483 13388 17 A2|17 8.95 cM mouse S696-p 31012805 KRPESVYsTSKDTKY transcription, induced 24449764 1 1 0 mutant shows increased stability +APP APP Apoptosis; Cell surface; Membrane protein, integral; Receptor, misc.; Transcription factor P05067 351 21q21.3 human S697-p 54165901 FFAEDVGsNKGAIIG Beta-APP protein conformation 26898910 2 0 0 forms oligomers without fibril formation, intraneuronal deposition, increased toxicity in human neurons +NUMB NUMB Cell development/differentiation P49757 8650 14q24.2-q24.3 human T102-p 3333403 LRVVDEKtKDLIVDQ PID activity, induced; intracellular localization endocytosis, altered 18657069 1 0 0 +Opn4 melanopsin GPCR, family 1; Membrane protein, integral; Membrane protein, multi-pass; Receptor, GPCR Q9QXZ9 30044 14|14 B mouse S381-p 36745800 QRSHPSLsYRSTHRS protein conformation; activity, inhibited 27181062; 32236094 3 1 0 +Wnk4 WNK4 EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, Other; Protein kinase, Ser/Thr (non-receptor) Q80UE6 69847 11|11 D mouse K1136-ub 40323314 EALQTLQkKEIEDLY protein degradation 23576762 1 1 0 regulates electrolyte homeostasis and involved in Pseudohypoaldosteronism type II (PHAII) pathogenesis +CUX1 CUTL1 DNA-binding; Membrane protein, integral; Transcription factor P39880 1523 7q22.1 human S1237-p 456479 TEYSQGAsPQPQHQL transcription, inhibited 16574653 2 8 4 +DNM1L DRP1 Apoptosis; EC 3.6.5.5; Endoplasmic reticulum; Hydrolase; Microtubule-binding; Mitochondrial; Motor O00429 10059 12p11.21 human S693-p 27276100 LVGQLYKsSLLDDLL GED enzymatic activity, inhibited apoptosis, inhibited 23185298 1 0 0 mitochondrial elongation +CRHR1 CRF-R1 iso2 GPCR, family 2; Membrane protein, integral; Membrane protein, multi-pass; Receptor, GPCR P34998-2 1394 17q21.31 human T399-p 454252 ARAMSIPtSPTRVSF receptor desensitization, altered 15498832 1 0 0 +TP53 p53 Activator; DNA-binding; Motility/polarity/chemotaxis; Nuclear receptor co-regulator; Transcription factor; Tumor suppressor P04637 7157 17p13.1 human K370-m3 2574936 RAHSSHLkSKKGQST molecular association, regulation JMJD2A(INDUCES) 19334741 1 1 0 strongest interaction with K370me3 +Fos Fos DNA-binding; Motility/polarity/chemotaxis; Oncoprotein; Transcription factor P01101 14281 12 D2|12 39.7 cM mouse S374-p 448482 PSSDSLSsPTLLAL_ carcinogenesis, induced; cell differentiation, induced; signaling pathway regulation 21119595 12 3 0 +Drgx DRGX DNA-binding Q8BYH0 107751 14|14 B mouse S231-p 62925705 ANLLPSTsSSPGPAS transcription, altered 28049756 1 1 0 +Cacna1b CACNA1B Channel, calcium; Membrane protein, integral; Membrane protein, multi-pass Q02294 257648 3p13 rat T422-p 465546 AVLKRAAtKKSRNDL activity, induced 16704976; 17294162; 19167461 4 0 0 +FLT1 VEGFR1 EC 2.7.10.1; KINASE; Kinase, protein; Membrane protein, integral; Protein kinase, TK; Protein kinase, tyrosine (receptor) P17948 2321 13q12.3 human Y1333-p 448212 DYNSVVLySTPPI__ protein degradation; molecular association, regulation; receptor internalization, altered cell cycle regulation; signaling pathway regulation; cell growth, altered PLCG1(INDUCES); NCK1(INDUCES); CBL(INDUCES); CRK(INDUCES) 11583921; 15001553; 25119572; 9722576 4 0 0 +Kcnb1 Kv2.1 Channel, cation; Channel, ligand-gated; Channel, potassium; Membrane protein, integral; Membrane protein, multi-pass P15387 25736 3q42 rat Y128-p 449085 YWGIDEIyLESCCQA BTB_2 activity, induced; molecular association, regulation; intracellular localization apoptosis, induced; signaling pathway regulation CAMK2A(INDUCES); STX1B(INDUCES); PTPRE(INDUCES) 12615930; 22106938; 23918396 7 0 0 +MRE11 MRE11A Cell cycle regulation; DNA repair, damage; DNA-binding; Deoxyribonuclease P49959 4361 11q21 human R572-me 2344809 ATNKGRGrGRGRRGG intracellular localization 15970667 1 0 0 localizes in nucleus and associates with nuclear bodies and sites of DNA damage +S1PR1 EDG-1 GPCR, family 1; Membrane protein, integral; Membrane protein, multi-pass; Receptor, GPCR P21453 1901 1p21.2 human T236-p 447691 RTRSRRLtFRKNISK 7tm_1 cell motility, altered; cytoskeletal reorganization 11583630 2 1 0 Cortical actin assembly, chemotaxis, and angiogenesis +CTBP1 CTBP1 Cell cycle regulation; EC 1.1.1.-; Nuclear receptor co-regulator; Oxidoreductase; Transcription, coactivator/corepressor Q13363 1487 4p16.3 human K428-sm 2407413 PSPGQTVkPEADRDH molecular association, regulation; intracellular localization transcription, inhibited nNOS(DISRUPTS) 12769861 2 0 0 +DNAJB1 HSP40 Chaperone; Nucleolus P25685 3337 19p13.12 human S149-p 30306601 TNVNFGRsRSAQEPA transcription, inhibited 24309468 1 0 0 +ETV4 ETV4 DNA-binding P43268 2118 17q21.31 human K226-sm 3144819 PYPQQSFkQEYHDPL ETS_PEA3_N transcription, inhibited 17585876 4 1 0 +Bcr Bcr EC 2.7.11.1; GAP; GAP, Rac/Rho; GEF, Rac/Rho; KINASE; Kinase, protein; Oncoprotein; Protein kinase, Ser/Thr (non-receptor); Protein kinase, atypical Q6PAJ1 110279 10 C1|10 38.49 cM mouse Y362-p 447796 VSPSPTTyRMFRDKS enzymatic activity, inhibited cell growth, altered 17934518 4 1 29 +IKBKB IKKB EC 2.7.11.10; KINASE; Kinase, protein; Protein kinase, Other; Protein kinase, Ser/Thr (non-receptor) O14920 3551 8p11.21 human S177-p 447492 AKELDQGsLCTSFVG Pkinase molecular association, regulation; ubiquitination; intracellular localization; phosphorylation; enzymatic activity, induced carcinogenesis, induced; cell growth, induced; transcription, induced; transcription, inhibited; signaling pathway regulation IKKA(INDUCES) 10195894; 11325957; 11460167; 16267042; 18930133; 23123196; 24833394; 34017102; 35173553; 35339487; 35525271; 9346484 43 1 0 TRIM26 enhances TLRs-induced NF-kB and MAPK signaling.; induces IKB phosphorylation; regulates NFkB signaling; induces induces nuclear localization of p65, thus inducing the TNFa/NF-kB signaling pathway; PKM2 expression +EDNRA EDNRA GPCR, family 1; Membrane protein, integral; Membrane protein, multi-pass; Motility/polarity/chemotaxis; Receptor, GPCR P25101 1909 4q31.22-q31.23 human S404-p 2911711 SVPMNGTsIQWKNHD receptor desensitization, induced 24064210 1 2 0 Lack of S397, T403 and S404 influences desensitization to a greater extent compared than S391, S393, and T396 +BLVRA BVR Cofactor and Vitamin Metabolism - porphyrin and chlorophyll; EC 1.3.1.24; KINASE; Kinase, protein; Oxidoreductase; Protein kinase, Ser/Thr (non-receptor) P53004 644 7p13 human S149-p 486325 GKDLLKGsLLFTAGP Biliv-reduc_cat phosphorylation transcription, induced 17639074 1 3 0 induces phosphorylation of PKCZ +WDR62 WDR62 Adaptor/scaffold O43379 284403 19q13.12 human S32-p 10989988 VPARRGQsSPPPAPP cell cycle regulation 25501809; 26713495 2 11 8 WDR62 regulation of the mitotic spindle; microtubule association +GATA1 GATA1 DNA-binding; Transcription factor P15976 2623 Xp11.23 human S187-p 451237 LNSAAYSsPKLRGTL molecular association, regulation carcinogenesis, induced; cell motility, induced HDAC3(INDUCES); HDAC4(INDUCES) 25726523 3 0 0 GATA1-HDAC3/4 complex induces EMT of breast cancer cells, inhibits E-cadherin and promotes fibronectin expression +Setdb1 SETDB1 Amino Acid Metabolism - lysine degradation; EC 2.1.1.43; METHYLTRANSFERASE; Methyltransferase; Methyltransferase, protein lysine O88974 84505 3|3 F2.1 mouse K884-ub 56394103 IESVENFkEGYESDV SET intracellular localization; enzymatic activity, induced cell differentiation, inhibited 33971063 3 3 0 K885A mutant of SETDB1 inhibits enzyme activity but not its localization to target genes, mutant represses some adipogenic genes and inhibits adipocyte differentiation as does WT, but others arenot repressed and don't may not require its enzymatic activity and other H3K9 methyltransferases may be able to compensate. +CGAS cGAS EC 2.7.7.86 Q8N884 115004 6q13 human K411-ub 1881951902 CCRKDCLkLMKYLLE molecular association, regulation; enzymatic activity, inhibited DNA(DISRUPTS) 35503863 1 0 0 impairs cGAMP increased antiviral synthesis +Nos1 nNOS Amino Acid Metabolism - arginine and proline; EC 1.14.13.39; Oxidoreductase P29476 24598 12q16 rat K229-ac 2459102 GPAKAEMkDTGIQVD activity, induced 18415985 1 1 0 +MACROH2A2 H2AFY2 DNA-binding Q9P0M6 55506 10q22.1 human K12-ub 1877384701 SGKKKMSkLSRSARA Histone intracellular localization DNA repair, induced 32424115 1 0 0 recruiting downstream DNA repair proteins to DNA breaks +PRC1 PRC1 Cell cycle regulation; Cytoskeletal; Microtubule-binding; Motility/polarity/chemotaxis O43663 9055 15q26.1 human S577-p 26331401 FSINSVAsTYSEFAK phosphorylation 17351640 1 0 0 Docking site phosphorylation at T616 is regulated T578 phosphorylation. +LIPE HSL iso2 EC 3.1.1.79; Lipase Q05469-2 3991 19q13.2 human S552-p 448803 IAEPMRRsVSEAALA intracellular localization signaling pathway regulation 22493722 41 11 2 induces lipolysis +SCN5A SCN5A Channel, sodium; Membrane protein, integral; Membrane protein, multi-pass Q14524 6331 3p22.2 human R513-m1 37043705 MNHLSLTrGLSRTSM Na_trans_cytopl phosphorylation 25501501 1 1 0 inhibits SCN5A S516 phosphorylation +PTK2 FAK EC 2.7.10.2; KINASE; Kinase, protein; Protein kinase, TK; Protein kinase, tyrosine (non-receptor) Q05397 5747 8q24.3 human Y576-p 447889 RYMEDSTyYKASKGK PK_Tyr_Ser-Thr activity, induced; intracellular localization; phosphorylation; enzymatic activity, induced carcinogenesis, induced; cell differentiation, altered; cell growth, induced; cell motility, induced; cell adhesion, altered; cytoskeletal reorganization; transcription, altered 12482769; 15561106; 15707572; 15735019; 17088251; 18437915; 23716717; 35999654 95 65 2523 +MST1R Ron EC 2.7.10.1; KINASE; Kinase, protein; Membrane protein, integral; Protein kinase, TK; Protein kinase, tyrosine (receptor) Q04912 4486 3p21.31 human Y1317-p 456484 EYCPDSLyQVMQQCW PK_Tyr_Ser-Thr cell growth, altered 11064459 2 0 0 +MYL12B MRLC2 Contractile O14950 103910 18p11.31 human T19-p 448596 KKRPQRAtSNVFAMF cell motility, altered; cytoskeletal reorganization 11781833; 12429016; 18984162 36 50 282 +Jak1 JAK1 EC 2.7.10.2; KINASE; Kinase, protein; Protein kinase, TK; Protein kinase, tyrosine (non-receptor) P52332 16451 4 C6|4 46.19 cM mouse Y939-p 3345201 YHENIVKyKGICMED PK_Tyr_Ser-Thr enzymatic activity, inhibited 18682290 1 0 0 mutation Y939F increases activity of Jak1 in vitro +Slc9a1 NHE1 Membrane protein, integral; Membrane protein, multi-pass; Motility/polarity/chemotaxis; Transporter; Transporter, SLC family P26431 24782 5q36 rat S707-p 448347 MSRARIGsDPLAYEP apoptosis, induced 16717153 9 73 199 +LCK Lck EC 2.7.10.2; KINASE; Kinase, protein; Oncoprotein; Protein kinase, TK; Protein kinase, tyrosine (non-receptor) P06239 3932 1p35.2 human Y192-p 447821 NLDNGGFyISPRITF SH2 molecular association, regulation; enzymatic activity, inhibited; activity, inhibited; phosphorylation signaling pathway regulation ZAP70(DISRUPTS); LAT(DISRUPTS); PLCG1(DISRUPTS) 34321230; 8798764 5 29 1070 leads to lower ERK activation and less protein binding (pTyr proteins in lysates and pTyr peptides in vitro through Lck's SH2 domain); regulates phosphorylation of itself and inhibits ZAP70 and CD3Z phosphorylation, thus inhibiting TCR signaling +MYO9B MYO9B Actin-binding; GAP; GAP, Rac/Rho; Motility/polarity/chemotaxis; Motor Q13459 4650 19p13.11 human S1290-p 1983797 RVQEKPDsPGGSTQI cell differentiation, inhibited 30872405 1 71 3 +FOS Fos DNA-binding; Motility/polarity/chemotaxis; Oncoprotein; Transcription factor P01100 2353 14q24.3 human T325-p 448483 TELEPLCtPVVTCTP carcinogenesis, induced; transcription, induced 23667255 5 0 1 nuclear import of HBXIP +FGFR3 FGFR3 EC 2.7.10.1; KINASE; Kinase, protein; Membrane protein, integral; Protein kinase, TK; Protein kinase, tyrosine (receptor) P22607 2261 4p16.3 human Y760-p 448117 TVTSTDEyLDLSAPF molecular association, regulation; enzymatic activity, induced cell growth, altered SH2-B-beta(INDUCES) 11294897; 11827956 2 0 0 +Nefm NFM Cytoskeletal P08553 18040 14|14 D1 mouse S502-p 448041 EEPEAEKsPVKSPEA cytoskeletal reorganization 19193875 3 11 6 slightly altered axoplasmic organization in 7S/A mice mutant +CDCA5 CDCA5 Cell cycle regulation Q96FF9 113130 11q13.1 human S75-p 470993 VEVPAVQsPRRSPRI molecular association, regulation cell cycle regulation H2A.1(DISRUPTS); SMC3(DISRUPTS) 21878504 2 34 6 +Foxo1 FOXO1A DNA-binding; Nuclear receptor co-regulator; Oncoprotein; Transcription factor Q9R1E0 56458 3 C|3 23.19 cM mouse S273-p 1253812002 RAAKKKAsLQSGQEG apoptosis, induced; transcription, induced 33408127; 37263346 4 1 0 +PELI3 PELI3 Adaptor/scaffold; EC 6.3.2.-; EC 6.3.2.19; Ligase; UBIQUITIN LIGASE; Ubiquitin conjugating system; Ubiquitin ligase Q8N2H9 246330 11q13.2 human K316-ub 37043502 LLRAPTLkQLEAQRQ Pellino protein degradation autophagy, induced; transcription, inhibited 25483963 1 2 0 autophagy-dependent degradation +NUP98 NUP98 iso2 Motility/polarity/chemotaxis; Nucleoporin P52948-2 4928 11p15.4 human S595-p 470432 LNNSNLFsPVNRDSE intracellular localization 21335236 2 57 5 as multiple sites (13PM) mutant +Dbnl DBNL Actin-binding; Motility/polarity/chemotaxis Q62418 13169 11 A1|11 3.87 cM mouse Y350-p 450091 PPEQDTLyEEPPLVQ cell motility, induced; cytoskeletal reorganization; cell motility, inhibited 22303001; 30504273 4 1 22 cell migration to CP; extracellular matrix degradation, inhibits invasive cell migration +FTO FTO DEMETHYLASE; Demethylase; EC 1.14.11.- Q9C0B1 79068 16q12.2 human T150-p 23108331 NDYLQIEtIQALEEL FTO_NTD intracellular localization cell cycle regulation; cell growth, inhibited; RNA stability, inhibited 32268083 1 0 1 +Slc12a1 NKCC2 Membrane protein, integral; Membrane protein, multi-pass; Transporter; Transporter, SLC family P55016 25065 3q36 rat T101-p 458228 LQTFGHNtMDAVPKI AA_permease_N activity, induced; molecular association, regulation; intracellular localization ANXA2(DISRUPTS) 16275913; 18550832; 24526686 14 2 0 Low chloride hypotonic stress enhances raft association of NKCC2 and AnxA2; observed in triple mutant T96/111/101A +Strap STRAP Adaptor/scaffold; RNA splicing; UBIQUITIN LIGASE; Ubiquitin ligase Q9Z1Z2 20901 6|6 G1 mouse S188-p 38410205 NFNMSVSsMEYIPEG activity, induced apoptosis, induced; transcription, induced; signaling pathway regulation 25485581 1 0 0 induces apoptosis through Ask1, TGF-beta, p53 and PI3K/PDK1 signaling pathways +PPP1R3F PPP1R3F Membrane protein, integral; Protein phosphatase, regulatory subunit Q6ZSY5 89801 Xp11.23 human S421-p 22650301 AIRIPPSsPLCGLGG signaling pathway regulation 21668450 0 2 0 regulation of glycogen synthesis via R3F-PP1 signaling in astrocytoma cells +XRCC6 Ku70 DNA repair, damage; DNA-binding; EC 3.6.4.-; EC 4.2.99.-; Helicase; Nuclear receptor co-regulator; RNA-binding P12956 2547 22q13.2 human S78-p 1875071708 YISKIISsDRDLLAV Ku_N molecular association, regulation; acetylation; intracellular localization DNA repair, inhibited; transcription, inhibited 14-3-3 beta(INDUCES); SIRT1(DISRUPTS) DNA(DISRUPTS) 34635772 1 1 0 +TAGLN2 TAGLN2 Cytoskeletal; Motility/polarity/chemotaxis P37802 8407 1q23.2 human S163-p 468770 KENPRNFsDNQLQEG molecular association, regulation carcinogenesis, induced; cell motility, induced; cytoskeletal reorganization ACTB(DISRUPTS) 21577206 1 63 34 +RIGI RIGI EC 3.6.4.13; Hydrolase O95786 23586 9p21.1 human K146-ub 62480702 ILQICSTkGMMAGAE CARD_2 protein degradation transcription, inhibited 27506794 1 0 0 +CFTR CFTR Channel, chloride; EC 3.6.3.49; Hydrolase; Membrane protein, integral; Membrane protein, multi-pass; Transporter; Transporter, ABC family P13569 1080 7q31.2 human S790-p 2907510 IHRKTTAsTRKVSLA CFTR_R activity, induced 12588899 2 0 0 +Eif4b EIF4B RNA-binding; Translation; Translation initiation Q5RKG9 300253 7q36 rat S504-p 452271 SSDTEQPsPTSGGGK intracellular localization translation, induced 28874824 2 55 22 increased in Bassoon-positive synaptic areas, up-regulation of PKM? +Akt1 Akt1 EC 2.7.11.1; KINASE; Kinase, protein; Oncoprotein; Protein kinase, AGC; Protein kinase, Ser/Thr (non-receptor) P47196 24185 6q32 rat T308-p 447856 KDGATMKtFCGTPEY Pkinase molecular association, regulation; protein conformation; phosphorylation cell cycle regulation; carcinogenesis, induced; cell growth, induced; cell adhesion, induced; apoptosis, inhibited; signaling pathway regulation BAD(INDUCES) 11027222; 21736902; 22031698; 33864097; 34221817; 34335915; 34475824; 34569407 802 14 18 +PTPN6 SHP-1 EC 3.1.3.48; Motility/polarity/chemotaxis; PHOSPHATASE; Protein phosphatase, tyrosine (non-receptor) P29350 5777 12p13.31 human S553-p 15415001 KNAHAKAsRTSSKHK enzymatic activity, induced cell adhesion, induced; signaling pathway regulation 21177494 1 0 2 Src activation via SHP-1 and SHP-2, and then ERK activation +MARS1 MARS Aminoacyl-tRNA synthetase; EC 6.1.1.10; Ligase; Other Amino Acids Metabolism - selenoamino acid; Translation; Translation regulation P56192 4141 12q13.3 human S825-p 3193240 GGGQAKTsPKPAVVE methylation; enzymatic activity, induced cell growth, induced; transcription, induced; translation, induced 25097229 1 32 7 induces Met-misacylation; reduce intracellular ROS level +RTCB RTCB EC 6.5.1.3 Q9Y3I0 51493 22q12.3 human Y306-p 55380503 ASPEGQDyLKGMAAA RtcB molecular association, regulation RNA splicing, inhibited; apoptosis, inhibited; signaling pathway regulation IRE1(DISRUPTS) 35193953 1 2 0 regulates IRE1-XBP1/RIDD signaling +CETN2 CETN2 Calcium-binding; Cell cycle regulation; DNA repair, damage P41208 1069 Xq28 human S158-p 34405001 RDGDGEVsEQEFLRI EF-hand_7 molecular association, regulation XPC(DISRUPTS) 24918055 1 0 0 +ATP7B ATP7B EC 3.6.3.54; Hydrolase; Membrane protein, integral; Membrane protein, multi-pass; Transporter; Transporter, ion channel; Vesicle P35670 540 13q14.3 human S341-p 25786201 SGTDHRSsSSHSPGS intracellular localization; protein conformation 22898812 1 0 0 mutant does not return to TGN in response to copper depletion; S340/341A mutant shifts ATP7B from trans-Golgi Network (TGN) to vesicles +CD3G CD3G Membrane protein, integral; Receptor, misc. P09693 917 11q23.3 human S148-p 451430 GVRQSRAsDKQTLLP receptor internalization, altered; activity, inhibited 8187769; 8626701 5 1 3 +Pik3ap1 BCAP Adaptor/scaffold Q9EQ32 83490 19|19 C3 mouse Y420-p 450044 GEEADDVyESMAHLS molecular association, regulation cell differentiation, altered PIK3R1(INDUCES) 18025150 2 0 9 regulate Akt activation and B-cell differentiation through binding to PI3KR1 +SMARCA4 SMARCA4 Cell cycle regulation; EC 3.6.1.-; EC 3.6.4.-; Helicase; Nuclear receptor co-regulator; Transcription, coactivator/corepressor; Tumor suppressor P51532 6597 19p13.2 human S721-p 481804 VDDEYGVsQALARGL molecular association, regulation DNA repair, induced H3(INDUCES) 24413084 1 1 4 enhances binding to gamma-H2AX nucleosomes and acetylated H3 peptides +MAD2L1 MAD2L1 Cell cycle regulation Q13257 4085 4q27 human S195-p 468160 TTIHKVNsMVAYKIP HORMA molecular association, regulation; protein conformation; activity, inhibited cell cycle regulation Mad1(DISRUPTS); CDC20(DISRUPTS) 12574116; 21041666 2 14 20 MAD2L1 S195D mutant bound to Mad1 with lower affinity in vitro but higher in vivo, as compared to MAD2L1-wt +Hdgf HDGF Cytokine; Transcription regulation Q8VHK7 114499 2q34 rat S103-p 18944905 KASGYQSsQKKSCAE activity, induced cell cycle regulation; cell growth, induced 21489262 1 3 0 +Gphn gephyrin Adaptor/scaffold; EC 2.10.1.1; EC 2.7.7.75 Q03555 64845 6q24 rat T289-p 31878238 ESPRAQAtSRLSTAS molecular association, regulation gephyrin(INDUCES) 22778260 1 2 0 oligomerization +BNIP3 BNIP3 Membrane protein, integral; Mitochondrial Q12983 664 10q26.3 human S24-p 27421703 SWVELHFsNNGNGGS BNIP3 molecular association, regulation; intracellular localization autophagy, induced LC3B(INDUCES); GABARAPL2(INDUCES) 23209295 1 0 0 S82 is required for binding and S89 positively regulates the affinity for LC3B and GABARAPL2. Mitochondrial degradation. +Nfil3 E4BP4 DNA-binding; Transcription factor O08750 18030 13 B1|13 27.68 cM mouse K219-sm 55429871 ENKFPVIkQEPVELE Vert_IL3-reg_TF transcription, inhibited 29311361 1 4 0 NK cell production inhibited +Slc11a2 SLC11A2 Membrane protein, integral; Membrane protein, multi-pass; Transporter; Transporter, SLC family P49282 18174 15 F1|15 56.29 cM mouse S43-p 59087904 LPHSTGDsEEPFTTY activity, induced 27681840 1 0 0 iron uptake +TTK TTK Cancer Testis Antigen (CTA); EC 2.7.12.1; KINASE; Kinase, protein; Protein kinase, Other; Protein kinase, dual-specificity (non-receptor) P33981 7272 6q14.1 human S436-p 950200 VFSVSKQsPPISTSK cytoskeletal reorganization 22430208 3 22 3 centrosome reduplication +ERN1 IRE1 Apoptosis; Chaperone; EC 2.7.11.1; Endoplasmic reticulum; KINASE; Kinase, protein; Membrane protein, integral; Protein kinase, Other; Protein kinase, Ser/Thr (non-receptor); Ribonuclease O75460 2081 17q23.3 human Y628-p 41192601 EHPNVIRyFCTEKDR Pkinase protein conformation 25968568 1 0 0 The apo-hIRE1 dimer is twisted compared to the phos-yIRE1 dimer, and the RNase domains are further apart. +PAK1 PAK1 EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, STE; Protein kinase, Ser/Thr (non-receptor) Q13153 5058 11q13.5-q14.1 human S144-p 448170 SNSQKYMsFTDKSAE intracellular localization; enzymatic activity, induced carcinogenesis, induced; cell growth, induced; cell adhesion, induced; apoptosis, inhibited; cytoskeletal reorganization; signaling pathway regulation 15333633; 21177766; 31660987; 36319849 24 28 138 induces the MAPK pathway; Inhibitors decreased the tumor growth by inhibiting the phosphorylation; PAK activation induces PAK translocation, increased membrane permeability and MRLC1 phosphorylation. +HDAC6 HDAC6 DEACETYLASE; Deacetylase; EC 3.5.1.98; Nuclear receptor co-regulator; Ubiquitin conjugating system Q9UBN7 10013 Xp11.23 human S412-p 56668621 DPCPMLEsPGAPCRS molecular association, regulation cell motility, induced PIN1(INDUCES) 30443180 1 2 0 nteraction of HDAC6 with Pin1 mediates cell motility +Rb1 Rb Nuclear receptor co-regulator; Oncoprotein; Transcription, coactivator/corepressor; Tumor suppressor P13405 19645 14 38.73 cM|14 D3 mouse S605-p 447977 MYLSPLRsPKKRTST molecular association, regulation cell cycle regulation; cell growth, induced; transcription, inhibited E2F1(DISRUPTS) 10207050; 35023164; 9671466 13 18 33 transcriptional downregulation of the E2F-1, E2F-2, dihydrofolate reductase, thymidine kinase, c-myc, proliferating-cell nuclear antigen, p107, and p21/Cip1 genes +SYK Syk EC 2.7.10.2; KINASE; Kinase, protein; Protein kinase, TK; Protein kinase, tyrosine (non-receptor) P43405 6850 9q22.2 human Y525-p 447661 ALRADENyYKAQTHG PK_Tyr_Ser-Thr enzymatic activity, induced carcinogenesis, induced; carcinogenesis, inhibited; cell growth, induced ITGAM(INDUCES) 11380624; 18818202; 30923129; 34132782; 37330581; 8657103 50 8 76 +IKBKB IKKB EC 2.7.11.10; KINASE; Kinase, protein; Protein kinase, Other; Protein kinase, Ser/Thr (non-receptor) O14920 3551 8p11.21 human Y199-p 449633 ELLEQQKyTVTVDYW Pkinase activity, induced; molecular association, regulation transcription, altered 12645577; 12707358; 26353931 6 1 0 +RB1 Rb Nuclear receptor co-regulator; Oncoprotein; Transcription, coactivator/corepressor; Tumor suppressor P06400 5925 13q14.2 human K874-ac 459027 NPPKPLKkLRFDIEG Rb_C molecular association, regulation; intracellular localization; phosphorylation cell cycle regulation; cell differentiation, induced; transcription, induced E2F1(DISRUPTS); MDM2(INDUCES) 11433299; 15044952; 16374512 4 1 0 +TFAP2A AP-2 alpha DNA-binding; Transcription factor P05549 7020 6p24.3 human S219-p 25581601 CSVPGRLsLLSSTSK TF_AP-2 activity, induced; molecular association, regulation transcription, induced DNA(INDUCES) 22561688; 27391154 3 0 0 IkB-alpha expression +LARP6 LARP6 Q9BRS8 55323 15q23 human S348-p 54436202 DPESNPTsPMAGRRH molecular association, regulation; intracellular localization translation, induced STRAP(INDUCES) 28112218 2 1 0 regulates collagen production, contributes to LARP6 nuclear distribution, asssociation of LARP6 with ER membrane. +RPS6 S6 Translation P62753 6194 9p22.1 human S235-p 448092 IAKRRRLsSLRASTS activity, induced; molecular association, regulation; enzymatic activity, induced cell cycle regulation; carcinogenesis, induced; carcinogenesis, inhibited; apoptosis, induced; cell motility, induced; signaling pathway regulation; cell growth, induced; apoptosis, inhibited RNA(INDUCES) 17360704; 20008839; 21601007; 21750219; 25738361; 34273354; 34523696; 34737445; 35596155; 35998013; 36216931; 36409827; 36635496; 36715448 246 60 972 +POU3F2 Oct7 DNA-binding; Motility/polarity/chemotaxis; Transcription factor P20265 5454 6q16.1 human S91-p 1868139200 GGGGGDGsPWSTSPL DNA repair, altered; signaling pathway regulation DNA(INDUCES) 30804224 1 0 0 +TUBA1A TUBA1A Cytoskeletal; Motility/polarity/chemotaxis Q71U36 7846 12q13.12 human K166-sm 1881132900 VDYGKKSkLEFSIYP sumoylation cytoskeletal reorganization 33394042 1 0 0 promotes microtubule catastrophe, attenuates MT polymerization, facilitates neurite extension +Cidec CIDEC Apoptosis P56198 14311 6|6 E3 mouse K236-ub 12718505 SLLPACLkMLQ____ protein degradation 20089860 1 0 0 +NFYB NFYB DNA-binding; Transcription factor P25208 4801 12q23.3 human K140-ub 22248373 PLKLYLQkFREAMKG molecular association, regulation; ubiquitination; methylation transcription, induced DNA(INDUCES) 23332751 1 1 0 +MAP4K1 HPK1 EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, STE; Protein kinase, Ser/Thr (non-receptor) Q92918 11184 19q13.2 human T165-p 455473 ISAQIGAtLARRLSF Pkinase protein degradation; enzymatic activity, induced transcription, altered 15743830; 24362026 2 0 0 +CYLD CYLD DEUBIQUITINASE; EC 3.4.19.12; Protease; Tumor suppressor; Ubiquitin conjugating system; Ubiquitin-specific protease Q9NQC7 1540 16q12.1 human S418-p 4745557 TTENRFHsLPFSLTK CYLD_phos_site ubiquitination; enzymatic activity, induced signaling pathway regulation 15870263; 24614225; 34610306 5 31 22 induces RIPK2 deubiquitination, and NOD2 signaling +Mark2 MARK2 EC 2.7.11.1; EC 2.7.11.26; KINASE; Kinase, protein; Protein kinase, CAMK; Protein kinase, Ser/Thr (non-receptor) O08679 60328 1q43 rat S91-p 26573803 IDKTQLNsSSLQKLF Pkinase cytoskeletal reorganization 17442826 1 0 0 neurite outgrowth +PARL PSARL Apoptosis; EC 3.4.21.105; Membrane protein, integral; Membrane protein, multi-pass; Mitochondrial; Protease Q9H300 55486 3q27.1 human T69-p 471331 PRRSDPGtSGEAYKR protein processing 17116872 1 1 0 involved in mitochondrial fragmentation +DDR2 DDR2 EC 2.7.10.1; KINASE; Kinase, protein; Membrane protein, integral; Protein kinase, TK; Protein kinase, tyrosine (receptor) Q16832 4921 1q23.3 human Y741-p 456863 NLYSGDYyRIQGRAV PK_Tyr_Ser-Thr phosphorylation 16186108 1 5 22 Stimulates autophosphorylation. Autophosphorylation induces Shc binding (site not determined). +MRE11 MRE11A Cell cycle regulation; DNA repair, damage; DNA-binding; Deoxyribonuclease P49959 4361 11q21 human S689-p 452321 KGVDFESsEDDDDDP protein stabilization; molecular association, regulation PIH1D1(INDUCES) 28436950 1 37 7 +RUNX1 AML1 iso8 DNA-binding; Oncoprotein; Transcription factor Q01196-8 861 21q22.12 human S293-p 454400 QYLGSIAsPSVHPAT protein degradation cell differentiation, induced 16046550; 17015473; 22531928 7 3 28 +RIPK3 RIPK3 EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, Ser/Thr (non-receptor); Protein kinase, TKL Q9Y572 11035 14q12 human K518-ub 1877365902 GWYNHSGk_______ phosphorylation 33369872 1 1 0 TBZ-induced necroptosis, necroptotic cell death, necroptosis-induced RIPK3 phosphorylation +SNAI1 Snail1 C2H2-type zinc finger protein; Transcription factor O95863 6615 20q13.13 human S11-p 11493500 SFLVRKPsDPNRKPN activity, induced; protein degradation; acetylation; protein stabilization; molecular association, regulation; intracellular localization; activity, inhibited carcinogenesis, induced; carcinogenesis, altered; cell growth, induced; transcription, induced; transcription, altered 14-3-3 sigma(INDUCES); JUB(DISRUPTS); HDAC1(INDUCES); LOXL3(INDUCES); SAP30(INDUCES); HDAC2(INDUCES) 19923321; 20940406; 22276203; 22791710 5 0 0 induces deacetylation and HDAC activity induced; blocks EMT +PAK1 PAK1 EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, STE; Protein kinase, Ser/Thr (non-receptor) Q13153 5058 11q13.5-q14.1 human T423-p 448177 PEQSKRStMVGTPYW Pkinase activity, induced; molecular association, regulation; enzymatic activity, inhibited; protein conformation; phosphorylation; enzymatic activity, induced carcinogenesis, induced; cell growth, induced; cell motility, induced; apoptosis, induced; cell adhesion, induced; cytoskeletal reorganization; signaling pathway regulation CDC42 iso1(INDUCES); PAK1(INDUCES) 10551809; 15893667; 17254971; 19574218; 25174975; 25466889; 27003261; 28842430; 29058761; 31660987; 33657382; 34799729; 36198272 39 4 11 +MAML1 MAML1 Transcription, coactivator/corepressor Q92585 9794 5q35.3 human K217-sm 13310802 LSLNKELkQEPVEDL molecular association, regulation transcription, inhibited HDAC7(INDUCES) 20203086 1 0 0 +RET Ret EC 2.7.10.1; KINASE; Kinase, protein; Membrane protein, integral; Oncoprotein; Protein kinase, TK; Protein kinase, tyrosine (receptor) P07949 5979 10q11.21 human Y1062-p 447625 TWIENKLyGMSDPNW molecular association, regulation; enzymatic activity, induced; phosphorylation apoptosis, induced; apoptosis, inhibited; cytoskeletal reorganization; transcription, altered; cell growth, altered SHP-2(INDUCES); IRS1(INDUCES); RAPGEF1(INDUCES); SHC1(NOT_REPORTED); FRS2(INDUCES); DOK6(INDUCES); GAB1(INDUCES); SHC3(INDUCES); SHC1(INDUCES); PKCA(INDUCES); CRK(INDUCES); PIK3R1(INDUCES) 10445857; 10919641; 10995764; 11002419; 11061555; 11313948; 11360177; 11713247; 11886862; 11956105; 12242309; 12444552; 12527893; 12771945; 14981541; 15286081; 15677445; 17210721; 20682772; 8663426 42 2 2 +WASF2 WAVE2 Actin-binding; Motility/polarity/chemotaxis Q9Y6W5 10163 1p36.11 human T346-p 18715502 VGFGSPGtPPPPSPP molecular association, regulation cell motility, altered; cytoskeletal reorganization 21419341 1 0 0 regulates WRC (WAVE2 regulatory complex) interaction with Arp2/3 and lamellipodial protrusion +Otud5 OTUD5 DEUBIQUITINASE; EC 3.4.19.12; Protease; Ubiquitin-specific protease Q3U2S4 54644 X A1.1|X 3.54 cM mouse S503-p 483402 AGGDRATsPLVSLYP protein degradation; protein stabilization; molecular association, regulation; ubiquitination; phosphorylation; enzymatic activity, induced cell cycle regulation; cell growth, induced; autophagy, inhibited; transcription, altered; signaling pathway regulation BTRC(DISRUPTS) 33110214 1 21 1 inhibits ubiquitination and induces stabilization of OTUD5 and BTRCP1 further causing DEPTOR degradation, regulates phosphorylation of mTOR targets, promotes OTUD5-?TrCP1-DEPTOR pathway +PRKCD PKCD EC 2.7.11.13; KINASE; Kinase, protein; Nuclear receptor co-regulator; Protein kinase, AGC; Protein kinase, Ser/Thr (non-receptor); Protein kinase, tyrosine (non-receptor); Tumor suppressor Q05655 5580 3p21.1 human S359-p 6319238 HKVLGKGsFGKVLLG Pkinase enzymatic activity, altered 25755284 3 2 0 Y313 indirectly decreases phosphorylation in the kinase domain ATP-positioning loop at Ser359 +Kirrel2 KIRREL2 Cell adhesion; Membrane protein, integral Q7TSU7 243911 7|7 B1 mouse Y595-p 23119553 TKDPTNGyYRVRGVS protein processing; intracellular localization 26324709 1 2 1 +MARCKS MARCKS Actin-binding; Motility/polarity/chemotaxis P12624 613548 cow S158-p 447786 KKKKKRFsFKKSFKL MARCKS exocytosis, induced 22013076 26 15 10 Calcium mobilization, degranulation induced and dissociation of MARCK5 from plasma membrane. +PDCD1 PD-1 Apoptosis; Membrane protein, integral Q15116 5133 2q37.3 human Y223-p 50293000 VPVFSVDyGELDFQW molecular association, regulation; phosphorylation SHP-2(INDUCES); SHP-1(INDUCES) 15240681; 31189114 3 1 0 induces dephosphorylation of target substrates after binding to SHP +ACTN4 ACTN4 Cytoskeletal; Motility/polarity/chemotaxis O43707 81 19q13.2 human Y4-p 11498501 ____MVDyHAANQSY molecular association, regulation; intracellular localization; protein conformation; phosphorylation apoptosis, induced; cell motility, inhibited; cytoskeletal reorganization; cell growth, altered ACTA1(DISRUPTS); ACTB(DISRUPTS) 19920151; 26012634; 31664084 5 0 0 +DAGLA NSDDR EC 3.1.1.-; Hydrolase; Membrane protein, integral; Membrane protein, multi-pass Q9Y4D2 747 11q12.2 human S782-p 27807805 APLATMEsLSDTESL enzymatic activity, inhibited 23502535 1 3 0 +CARD11 CARD11 Adaptor/scaffold Q9BXL7 84433 7p22.2 human S116-p 466431 KEPTRRFsTIVVEEG molecular association, regulation Bcl-10(INDUCES) 16809782 1 0 1 +FUS hnRNP P2 DNA-binding; Nuclear receptor co-regulator; Oncoprotein; RNA splicing; RNA-binding; SUMO LIGASE P35637 2521 16p11.2 human R521-me 1873375602 RGEHRQDrRERPY__ intracellular localization KPNB2(DISRUPTS) 22968170 1 0 0 Arginines in the RGG3 domain are required for nuclear import of mutant hnRNP, and arginine methylation in this domain reduces KPNB2 binding. +Ppp1r1b DARPP-32 Motility/polarity/chemotaxis; Protein phosphatase, regulatory subunit Q6J4I0 360616 10q31 rat T34-p 448047 MIRRRRPtPALLFRV DARPP-32 enzymatic activity, inhibited; protein conformation; phosphorylation neural plasticity; cell motility, induced; signaling pathway regulation; transcription, altered PPP1CA(INDUCES) 15066157; 19651774; 21564097; 35835216; 8226946 67 6 44 +CD226 DNAM-1 Cell adhesion; Immunoglobulin superfamily; Membrane protein, integral Q15762 10666 18q22.2 human Y322-p 454845 DDTREDIyVNYPTFS activity, induced; phosphorylation cell growth, induced; cell adhesion, induced; signaling pathway regulation 12847109; 32265229 6 2 69 induces IFN-gamma secretion, phosphorylation of ERK, p38, AKT and hence TCR signaling +Cacybp CACYBP Adaptor/scaffold; Ubiquitin conjugating system Q9CXW3 12301 1|1 H2.1 mouse T184-p 15402545 KEKPSYDtEADPSEG SGS enzymatic activity, inhibited signaling pathway regulation 26085436 1 3 5 ERK and Elk-1 +Sox2 SOX2 Cell development/differentiation; DNA-binding; Transcription factor P48432 20674 3 A3|3 16.93 cM mouse S253-p 6738002 VKSEASSsPPVVTSS protein stabilization; molecular association, regulation; intracellular localization carcinogenesis, induced; transcription, induced DNA(INDUCES) 35944584 4 13 0 +FNIP1 FNIP1 Q8TF40 96459 5q31.1 human S938-p 1861699800 WDIPRNEsSDSALGD protein stabilization; molecular association, regulation; phosphorylation signaling pathway regulation HSP90A(INDUCES) DNA(INDUCES) 30699359 1 1 0 +TNNI3 TNNI3 Actin-binding; Motility/polarity/chemotaxis; Motor P19429 7137 19q13.42 human Y26-p 3545720 IRRRSSNyRAYATEP Troponin-I_N molecular association, regulation 25252176 1 2 7 accelerates Ca2+ dissociation from TNNI3 on the thin filament +Akt1 Akt1 EC 2.7.11.1; KINASE; Kinase, protein; Oncoprotein; Protein kinase, AGC; Protein kinase, Ser/Thr (non-receptor) P31750 11651 12 F1|12 61.2 cM mouse T308-p 447856 KDGATMKtFCGTPEY Pkinase activity, induced; protein degradation; molecular association, regulation; ubiquitination; intracellular localization; phosphorylation; enzymatic activity, induced cell cycle regulation; carcinogenesis, induced; apoptosis, altered; cell motility, induced; RNA stability, induced; cell motility, inhibited; signaling pathway regulation; cell differentiation, altered; RNA splicing, induced; cell growth, induced; translation, induced; cell growth, altered; transcription, induced; transcription, altered; neural plasticity; autophagy, induced; cell differentiation, induced; apoptosis, inhibited; autophagy, inhibited; cytoskeletal reorganization PPP2CA(INDUCES); PPP2R5B(INDUCES); HSP90A(NOT_REPORTED); CHIP(INDUCES) 10722653; 11445557; 11563975; 14623889; 18851840; 19325558; 20303298; 20332342; 21329884; 21550972; 21767636; 21775285; 21852229; 22509246; 28600288; 32116552; 33048163; 33664496; 33742122; 33836590; 33869980; 33876772; 34556581; 34664403; 34714866; 34910106; 34921114; 35210408; 35449295; 35489019; 35583996; 35641033; 35921893; 36198369; 36884349; 37384528; 37418003; 37610873 802 14 18 +PHOX2A PHOX2A DNA-binding; Transcription factor O14813 401 11q13.4 human S206-p 9400300 GLASPRLsPSPLPVA molecular association, regulation; phosphorylation transcription, inhibited DNA(DISRUPTS) 19564421 1 1 0 regulates phosphorylation of PHOX2A S153; inhibits neuronal differentiation +ESRRG ERR3 DNA-binding; Nuclear receptor; Transcription factor P62508 2104 1q41 human S45-p 1725304 FIKTEPSsPASLTDS sumoylation transcription, inhibited 19067653 2 0 0 +Mef2c MEF2C DNA-binding; Transcription factor Q8CFN5 17260 13 C3|13 43.68 cM mouse S59-p 447999 NKLFQYAsTDMDKVL transcription, induced 8663403 2 0 0 +CFLAR CFLAR Apoptosis O15519 8837 2q33.1 human K167-ub 27811902 HRIDLKTkIQKYKQS DED protein degradation; ubiquitination apoptosis, induced 23519470; 28218919 3 1 0 concomitant sensitization of cancer cells to TRAIL-induced apoptosis; required for ROS-dependent degradation of CFLAR; mutation of T166, K167 or both ablates ROS-dependent CFLAR ubiquitination and degradation +Gsk3a GSK3A EC 2.7.11.1; EC 2.7.11.26; KINASE; Kinase, protein; Protein kinase, CMGC; Protein kinase, Ser/Thr (non-receptor) P18265 50686 1q21 rat S21-p 448584 SGRARTSsFAEPGGG enzymatic activity, inhibited apoptosis, altered 11035810; 20841359 156 24 277 phosphorylation decreases apoptosis +GSTP1 GSTP1 EC 2.5.1.18; Other Amino Acids Metabolism - glutathione; Transferase; Xenobiotic Metabolism - drug metabolism - cytochrome P450; Xenobiotic Metabolism - metabolism by cytochrome P450 P09211 2950 11q13.2 human S43-p 455117 VETWQEGsLKASCLY GST_N activity, induced 15604283 2 2 2 +EWSR1 EWS Oncoprotein; RNA-binding; Transcription, coactivator/corepressor Q01844 2130 22q12.2 human T79-p 7359501 QPPTGYTtPTAPQAY molecular association, regulation; intracellular localization cell cycle regulation AurB(INDUCES) 33293370 2 0 0 induces aneuploidy in EWS/FLI1 cells; as EWS/FLI1 fusion +PTEN PTEN Carbohydrate Metabolism - inositol phosphate; EC 3.1.3.16; EC 3.1.3.48; EC 3.1.3.67; Motility/polarity/chemotaxis; Nuclear receptor co-regulator; PHOSPHATASE; Phosphatase, lipid; Tumor suppressor P60484 5728 10q23.31 human T382-p 448314 DHYRYSDtTDSDPEN molecular association, regulation; protein stabilization; intracellular localization; enzymatic activity, inhibited; protein conformation; phosphorylation; enzymatic activity, altered cell cycle regulation; neural plasticity; cell differentiation, altered; carcinogenesis, inhibited; chromatin organization, altered; cell motility, altered; transcription, altered PTEN(DISRUPTS); AIP1(DISRUPTS) DNA(INDUCES) 10866658; 11035045; 11431330; 17240336; 17565999; 22413754; 24766807; 25823029; 35240162; 36155262 22 2 0 induces EGFR degradation; regulates CHK1 phosphorylation and activation and H2AX phosphorylation +Pfn1 profilin 1 Actin-binding; Cytoskeletal; Motility/polarity/chemotaxis P62962 18643 11 B3|11 43.21 cM mouse S138-p 2850008 MASHLRRsQY_____ Profilin cytoskeletal reorganization 33108594 9 0 0 +TEK TIE2 EC 2.7.10.1; KINASE; Kinase, protein; Membrane protein, integral; Protein kinase, TK; Protein kinase, tyrosine (receptor) Q02763 7010 9p21.2 human Y897-p 459394 GACEHRGyLYLAIEY PK_Tyr_Ser-Thr enzymatic activity, inhibited 11080633 1 1 25 +PRKACA PKACA EC 2.7.11.11; KINASE; Kinase, protein; Protein kinase, AGC; Protein kinase, Ser/Thr (non-receptor) P17612 5566 19p13.12 human S11-p 469998 AAAAKKGsEQESVKE protein conformation 21740913 4 4 0 +KDM4B JMJD2B DEMETHYLASE; Demethylase; EC 1.14.11.-; Oxidoreductase O94953 23030 19p13.3 human K337-ub 31914119 YELWKQGkDLTVLDH protein degradation 23589305 1 3 0 +CFTR CFTR Channel, chloride; EC 3.6.3.49; Hydrolase; Membrane protein, integral; Membrane protein, multi-pass; Transporter; Transporter, ABC family P13569 1080 7q31.2 human S641-p 2907508 QNLQPDFsSKLMGCD CFTR_R activity, induced; protein conformation; activity, inhibited 12588899; 14695900; 32123855 3 0 0 +RASSF1 RASSF1 iso2 Tumor suppressor Q9NS23-2 11186 3p21.31 human S203-p 484000 TSVRRRTsFYLPKDA RA protein degradation; molecular association, regulation; ubiquitination cell cycle regulation; apoptosis, altered; apoptosis, inhibited; cytoskeletal reorganization; transcription, altered TUBA1A(DISRUPTS); SKP2(INDUCES); CDC20(DISRUPTS) 17563743; 18071316; 18514071; 19276349; 20655196; 21874044 7 10 1 APC/C-dependent ubiquitination of RASSF1 +TPX2 TPX2 Cell cycle regulation; Microtubule-binding Q9ULW0 22974 20q11.21 human S486-p 455699 LPITVPKsPAFALKN TPX2_importin protein stabilization carcinogenesis, induced; cell motility, induced; cell growth, induced 31272499 1 38 108 +Cldn1 Claudin-1 Cytoskeletal; Membrane protein, integral; Membrane protein, multi-pass O88551 12737 16|16 B2 mouse T203-p 451428 PRPYPKPtPSSGKDY intracellular localization 15051488 1 0 0 +Dok7 DOK7 Activator; Adaptor/scaffold Q18PE0 231134 5|5 B2 mouse Y396-p 17535701 CPPGAAEyQVPTSLR molecular association, regulation; phosphorylation MUSK(INDUCES); CRKL(INDUCES); CRK(INDUCES) 21041412 2 2 0 plays an important role in AChR clustering; stimulates MuSK and AChR phosphorylation +Rbl2 Rb-like 2 Transcription, coactivator/corepressor; Tumor suppressor Q64700 19651 8 C4|8 44.25 cM mouse S636-p 449726 DEIYIAGsPLTPRRV molecular association, regulation cell cycle regulation DNA(DISRUPTS) 36542833 4 24 31 +KRT6A K6a Cytoskeletal P02538 3853 12q13.13 human K204-ub 348335700 LLQEQGTkTVRQNLE Filament ubiquitination 29191848 1 1 0 +Atp12a ATP12A EC 3.6.3.10; Energy Metabolism - oxidative phosphorylation; Hydrolase; Membrane protein, integral; Membrane protein, multi-pass; Transporter; Transporter, ion channel P54708 171028 15p12 rat S955-p 465553 IRKTRRNsIFQQGLF Cation_ATPase_C activity, induced; protein stabilization; intracellular localization 16738016 1 0 0 important for transporter functions +CDC25C CDC25C EC 3.1.3.48; Motility/polarity/chemotaxis; PHOSPHATASE; Protein phosphatase, dual-specificity P30307 995 5q31.2 human K151-ub 485772 MCSSSANkENDNGNL protein degradation cell cycle regulation; cell growth, inhibited 11842186 1 0 2 +Syn2 SYN2 Vesicle Q64332 20965 6 E3|6 53.2 cM mouse S10-p 449839 NFLRRRLsDSSFIAN Synapsin_N intracellular localization 17341582 6 1 0 Mutation S10A synapsin inhibits basal cell surface Glut4 four-fold. +CACNA1H CACNA1H Cell development/differentiation; Channel, calcium; Membrane protein, integral; Membrane protein, multi-pass O95180 8912 16p13.3 human S1198-p 22648004 TPLRRAEsLDPRPLR signaling pathway regulation 16917542 2 0 0 +OCLN occludin Cell adhesion; Membrane protein, integral; Membrane protein, multi-pass; Motility/polarity/chemotaxis Q91049 chicken Y383-p 458611 ESQYETDyTTAVESS molecular association, regulation; intracellular localization ZO1(INDUCES) 19017651 1 4 6 +KRT8 K8 Cytoskeletal P05787 3856 12q13.13 human S432-p 448540 SAYGGLTsPGLSYSL intracellular localization carcinogenesis, induced; carcinogenesis, inhibited; cell motility, induced; cell growth, inhibited; apoptosis, induced; cell motility, inhibited; cell motility, altered; cytoskeletal reorganization 10623656; 15368451; 17158917; 19115206; 21840417; 22114688; 22344252; 26303380; 27403885; 28209923; 29796162; 32365802 27 8 23 phosphorylation reduces keratin filament length, formation of connectivity-depleted and mechanically weaker networks; enhanced migration and invasion; reorganization of keratin filaments to perinuclear ring; induces solubility of keratin filaments and inhibits polymerization +ITGB3 ITGB3 Cell adhesion; Membrane protein, integral; Motility/polarity/chemotaxis P05106 3690 17q21.32 human Y785-p 448013 STFTNITyRGT____ Integrin_b_cyt molecular association, regulation; intracellular localization; protein processing; activity, inhibited cytoskeletal reorganization; cell adhesion, altered GRB2(INDUCES); kindlin-2(DISRUPTS); SHC1(INDUCES); tensin 1 iso1(INDUCES) 11723131; 14996908; 15699036; 16935858; 17473008; 20702409; 8631894 21 2 6 +PBRM1 polybromo 1 DNA-binding; Tumor suppressor Q86U86 55193 3p21.1 human S948-p 453717 SGLHRTYsQDCSFKN transcription, inhibited 25066234 1 17 33 early DNA repair +DPYSL3 CRMP-4 Hydrolase Q14195 1809 5q32 human S518-p 458799 KGGTPAGsARGSPTR carcinogenesis, induced 30154149 1 23 10 +Cd300a MAIR-I Immunoglobulin superfamily; Membrane protein, integral Q6SJQ0 217303 11 E2|11 80.54 cM mouse Y262-p 455226 SQVEVVEySTLALPQ SIT molecular association, regulation SHIP(INDUCES); SHP-2(INDUCES); SHP-1(INDUCES) 15569773 1 1 7 +PAK1 PAK1 EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, STE; Protein kinase, Ser/Thr (non-receptor) Q13153 5058 11q13.5-q14.1 human Y201-p 487519 PEHTKSVyTRSVIEP protein stabilization; molecular association, regulation; intracellular localization; enzymatic activity, induced carcinogenesis, induced; apoptosis, altered; cell motility, induced; transcription, induced; signaling pathway regulation; cell growth, induced; cell motility, altered; cytoskeletal reorganization GIT1(INDUCES); ARHGEF7(INDUCES); Snail1(INDUCES) 17726028; 21566085; 21719533; 23340249; 25125660; 25466889; 26944939; 27003261; 27542844 9 0 0 PAK1 phosphorylation stimulates PRL-induced tumor metastasis +USP28 USP28 DEUBIQUITINASE; EC 3.4.19.12; Protease; Ubiquitin-specific protease Q96RU2 57646 11q23.2 human S67-p 467252 DERVKEPsQDTVATE molecular association, regulation; ubiquitination; enzymatic activity, induced carcinogenesis, induced; DNA repair, induced; apoptosis, altered KLHL2(DISRUPTS) 16901786; 31938050; 34611298 3 5 0 induces substrate deubiquitination +FLCN FLCN Tumor suppressor Q8NFG4 201163 17p11.2 human S62-p 3206874 NSRMRAHsPAEGASV protein degradation; molecular association, regulation; intracellular localization; activity, inhibited; enzymatic activity, induced; phosphorylation cell cycle regulation; carcinogenesis, induced; cell growth, induced; autophagy, inhibited; signaling pathway regulation FNIP2(INDUCES); RRAGC(DISRUPTS) 23874397; 31395606; 37083230 5 56 5 regulates mTORC1 localization and activity, induces TFEB phosphorylation; induces localization of mTORC1, increases phosphorylation of mTORC1 targets, regulates mTORC1 pathway +DAB1 DAB1 Adaptor/scaffold O75553 1600 1p32.2-p32.1 human Y220-p 447630 PETEENIyQVPTSQK molecular association, regulation CRK(INDUCES) 15316068 12 2 0 +H3C14 HIST2H3A/C/D DNA-binding Q71DI3 126961 1q21.2 human K4-m2 33597100 ____ARTkQTARKST Histone chromatin organization, altered; transcription, induced 20075197 1 0 0 +THRB TR-beta1 DNA-binding; Nuclear receptor P10828 7068 3p24.2 human K146-sm 27490403 LHPSYSCkYEGKCVI zf-C4 molecular association, regulation; intracellular localization cell growth, induced; cell differentiation, induced; transcription, induced; transcription, inhibited; signaling pathway regulation; transcription, altered CBP(DISRUPTS); N-CoR1(INDUCES) DNA(INDUCES); DNA(DISRUPTS) 22930759; 25572392 3 0 0 +RIPK1 RIPK1 EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, Ser/Thr (non-receptor); Protein kinase, TKL Q13546 8737 6p25.2 human S161-p 20536001 IADLGLAsFKMWSKL PK_Tyr_Ser-Thr enzymatic activity, induced 18408713 4 1 0 necroptosis regulation +APEX1 APE1 DNA repair, damage; DNA-binding; Deoxyribonuclease; EC 4.2.99.18; Endoplasmic reticulum; Hydrolase; Lyase; Nuclear receptor co-regulator; Nucleolus; Transcription, coactivator/corepressor P27695 328 14q11.2 human K32-ac 15207803 KSKTAAKkNDKEAAG acetylation; molecular association, regulation; intracellular localization; protein conformation; enzymatic activity, induced DNA repair, induced; cell growth, induced; cell growth, inhibited NPM1(DISRUPTS); XRCC1(INDUCES) RNA(DISRUPTS) 20699270; 22918947; 27994014 4 3 0 +NHERF1 NHERF Adaptor/scaffold; Motility/polarity/chemotaxis O14745 9368 17q25.1 human S280-p 470168 LAEAALEsPRPALVR EBP50_C molecular association, regulation; protein conformation cell cycle regulation; cell growth, inhibited; apoptosis, induced; cytoskeletal reorganization; cell adhesion, inhibited ACTB(INDUCES) 23775624; 30326259 4 84 121 increased cell invasion, regulates invadopodial activity, cell proliferation inhibited, development of VM network, regulates metastatic potency and organotropism +GAB1 GAB1 Adaptor/scaffold; Motility/polarity/chemotaxis Q13480 2549 4q31.21 human Y627-p 447948 KGDKQVEyLDLDLDS molecular association, regulation; phosphorylation cell cycle regulation SYP(INDUCES); SHP-2(INDUCES); PIK3R1(INDUCES) 11323411; 15574420; 9658397; 9890893 24 25 438 Binding of SHP-2 to Gab1 leads to ERK activation. +IKBKG IKKG Adaptor/scaffold; Protein kinase, regulatory subunit Q9Y6K9 8517 Xq28 human S17-p 50564412 LCEMVQPsGGPAADQ protein stabilization transcription, induced 27929056 1 0 3 +CEP250 CEP250 Cell cycle regulation Q9BV73 11190 20q11.22 human S2421-p 20831305 LDESLTQsLTSPGPV intracellular localization cell cycle regulation 21723128; 25660448 3 2 1 +Dlgap1 SAPAP1 Cytoskeletal P97836 65040 9q38 rat S77-p 9418959 FPRRHYTsQQELKDE protein degradation; ubiquitination cytoskeletal reorganization 21829588 1 0 0 +Pacsin1 PACSIN1 Adaptor/scaffold Q61644 23969 17|17 A3.3 mouse S358-p 4730500 QTYATEWsDDESGNP molecular association, regulation cytoskeletal reorganization RAC1(INDUCES) 23420842 1 4 1 dendritic spine formation; S358 phosphorylation disrupts PACSIN1-ARHGAP17-Rac complex which is essential for Rac1 hydrolysis. +CEBPA C/EBP-alpha DNA-binding; Transcription factor P49715 1050 19q13.11 human K161-sm 2793923 ALRPLVIkQEPREED protein degradation cell cycle regulation; cell differentiation, inhibited; cell growth, induced; transcription, inhibited 17671234; 30644437 5 1 0 MORC2 overexpression +IMMT IMMT Membrane protein, integral; Mitochondrial Q16891 10989 2p11.2|2 human S528-p 55571502 ELQFRRLsQEQVDNF Mitofilin intracellular localization 27153535 1 1 0 Parkin recruitment to mitochondria was negatively regulated by PKA-mediated phosphorylation of S528 of MIC60 and T11 of MIC19 +DDX1 DDX1 EC 3.6.4.13; Helicase; RNA-binding Q92499 1653 2p24.3 human S377-p 36406801 DEADGLLsQGYSDFI DEAD molecular association, regulation RNA(INDUCES) 25176654 1 0 0 induces binding and maturatiuon of pri-miRNAs +RPA1 RPA1 DNA-binding P27694 6117 17p13.3 human K163-ac 461501 SKAYGASkTFGKAAG molecular association, regulation DNA repair, induced XPA(INDUCES) 28854354; 28854355 2 4 21 +EGFR EGFR EC 2.7.10.1; KINASE; Kinase, protein; Membrane protein, integral; Oncoprotein; Protein kinase, TK; Protein kinase, tyrosine (receptor) P00533 1956 7p11.2 human Y978-p 457580 MARDPQRyLVIQGDE molecular association, regulation STAT5A(INDUCES); SHP-2(INDUCES) 16729043 1 4 3 +PRKAR1A PKAR1A Protein kinase, regulatory subunit P10644 5573 17q24.2 human S77-p 468450 KAGTRTDsREDEISP molecular association, regulation; enzymatic activity, inhibited PKACA(INDUCES) 23942052; 35977512 2 39 30 +Opn4 melanopsin GPCR, family 1; Membrane protein, integral; Membrane protein, multi-pass; Receptor, GPCR Q9QXZ9 30044 14|14 B mouse T389-p 23257069 YRSTHRStLSSQSSD molecular association, regulation; protein conformation ARRB1(INDUCES) 32236094 1 1 1 +MAP4 MAP4 Cytoskeletal; Motility/polarity/chemotaxis P27816 4134 3p21.31 human S787-p 448480 KAPEKRAsPSKPASA activity, inhibited cell cycle regulation; cytoskeletal reorganization 10791892; 25746230; 35081344 7 34 6 +HSF4 HSF4 Cell development/differentiation; DNA-binding; Transcription, coactivator/corepressor Q9ULV5 3299 16q22.1 human K206-ub 50792301 GPSNAGGkRKLSLML protein degradation 26319152 1 0 0 +Ddx4 DDX4 EC 3.6.4.13; Helicase Q61496 13206 13 D2.2|13 63.87 cM mouse K405-ac 11325118 RLMDIIGkEKIGLKQ DEAD molecular association, regulation RNA(DISRUPTS) 22223882 1 1 0 selective RNA-binding activity +Cgas cGAS EC 2.7.7.86 Q8C6L5 214763 9|9 E1 mouse S291-p 36128853 VEKEKPGsPAVTLLI Mab-21 enzymatic activity, inhibited 26440888 3 2 0 inhibits cytokine production and IFN response upon infection with DNA viruses +DRD3 DRD3 GPCR, family 1; Membrane protein, integral; Membrane protein, multi-pass; Receptor, GPCR P35462 1814 3q13.31 human S257-p 482886 LELKRYYsICQDTAL 7tm_1 receptor desensitization, altered; receptor internalization, altered FLNA(INDUCES) 17536008 1 0 0 +NFAT5 NFAT5 Transcription factor O94916 10725 16q22.1 human S134-p 6223353 NTVQQHPsTPKRHTV intracellular localization 21209322 1 2 3 +DAB2 DAB2 Adaptor/scaffold; Tumor suppressor P98082 1601 5p13.1 human S423-p 7320788 LESSVQSsPHDSIAI intracellular localization 21097498 1 3 0 displacement of Dab2 from the membrane +Slc12a3 NCCT Membrane protein, integral; Membrane protein, multi-pass; Transporter; Transporter, SLC family P59158 20497 8 C5|8 46.46 cM mouse S71-p 469631 AYEHYANsALPGEPR AA_permease_N activity, induced; ubiquitination 22846565; 25472608 15 2 1 +IRS1 IRS1 Adaptor/scaffold; Motility/polarity/chemotaxis P35568 3667 2q36.3 human S616-p 447562 DDGYMPMsPGVAPVP molecular association, regulation; intracellular localization; activity, inhibited signaling pathway regulation PIK3R1(DISRUPTS) 12917346; 16914728; 9335553 37 7 4 morphine-inhibited insulin receptor signaling; via cell fractionation experiments; Phosphorylated S616 results in an inhibition of insulin signaling. +Map4 MAP4 Cytoskeletal; Motility/polarity/chemotaxis P27546 17758 9 F2|9 59.83 cM mouse S760-p 448480 KVAEKRTsPSKPSSA intracellular localization cell differentiation, inhibited; apoptosis, induced; cytoskeletal reorganization 30327268; 35902952 7 34 6 +Nfat5 NFAT5 Transcription factor D3ZGB1 rat Y160-p 12127405 PKRHTVLyISPPPED activity, induced; intracellular localization transcription, induced 20585028 5 1 0 +KCNA5 Kv1.5 Channel, potassium; Membrane protein, integral; Membrane protein, multi-pass P22460 3741 12p13.32 human T15-p 465994 LENGGAMtVRGGDEA activity, induced; protein degradation; ubiquitination endocytosis, induced 16466689; 33676894 2 0 0 +EPAS1 HIF2A DNA-binding; Transcription factor Q99814 2034 2p21 human S484-p 1876807202 SSCSTPNsPEDYYTS protein stabilization; molecular association, regulation; ubiquitination carcinogenesis, induced; cell growth, induced; apoptosis, inhibited; transcription, induced USP33(INDUCES) 35191554 1 0 0 induces deubiquitination +NR1I2 PXR DNA-binding; Nuclear receptor O75469 8856 3q13.33 human T248-p 27839401 PHMADMStYMFKGII Hormone_recep molecular association, regulation transcription, induced DNA(DISRUPTS) 22976785 1 0 0 +Alyref2 Refbp2 DNA-binding; RNA-binding Q9JJW6 56009 1|1 H3 mouse R24-m1 13906418 RNQRRVNrGGGPRRN molecular association, regulation RNA(DISRUPTS) 20129943 1 1 0 +Zap70 ZAP70 EC 2.7.10.2; KINASE; Kinase, protein; Protein kinase, TK; Protein kinase, tyrosine (non-receptor) P43404 22637 1 B|1 15.41 cM mouse K25-ub 15400590 AEAEEHLkLAGMADG SH2 protein degradation 31061531 1 3 1 +Bcl2 Bcl-2 Apoptosis; Autophagy; Membrane protein, integral; Oncoprotein P10417 12043 1 E2.1|1 49.76 cM mouse S84-p 448396 ATAGPALsPVPPVVH molecular association, regulation; protein stabilization; protein conformation; phosphorylation cell cycle regulation; autophagy, induced; apoptosis, induced; apoptosis, inhibited BAX(DISRUPTS) 14660795; 32051584; 35183115 22 1 0 +Dpysl2 CRMP-2 Microtubule-binding; Motility/polarity/chemotaxis O08553 12934 14 D1|14 34.6 cM mouse T509-p 448083 PVCEVSVtPKTVTPA molecular association, regulation DRP1(DISRUPTS); RHOT2(DISRUPTS) 34685760 16 63 34 +PHB1 PHB Apoptosis; Cell cycle regulation; Chaperone; Mitochondrial; Motility/polarity/chemotaxis; Nuclear receptor co-regulator; Oncoprotein; Transcription, coactivator/corepressor P35232 5245 17q21.33 human T258-gl 6374002 LSRSRNItYLPAGQS phosphorylation 19238206 1 0 0 +ESR1 ER-alpha DNA-binding; Nuclear receptor; Transcription factor P03372 2099 6q25.1-q25.2 human K266-sm 3617606 RRGGRMLkHKRQRDD molecular association, regulation transcription, induced DNA(INDUCES) 15961505 1 0 0 +Jak2 JAK2 EC 2.7.10.2; KINASE; Kinase, protein; Oncoprotein; Protein kinase, TK; Protein kinase, tyrosine (non-receptor) Q62120 16452 19 C1|19 23.73 cM mouse Y913-p 3345200 QHDNIVKyKGVCYSA PK_Tyr_Ser-Thr enzymatic activity, inhibited cell growth, altered 18682290 1 0 0 mutation Y913F increases activity of Jak2 in vitro +PTPN18 BDP1 EC 3.1.3.48; Motility/polarity/chemotaxis; PHOSPHATASE; Protein phosphatase, tyrosine (non-receptor) Q99952 26469 2q21.1 human Y354-p 450261 GHAMADTyAVVQKRG molecular association, regulation TEC(INDUCES) 14679216 1 0 0 +PTEN PTEN Carbohydrate Metabolism - inositol phosphate; EC 3.1.3.16; EC 3.1.3.48; EC 3.1.3.67; Motility/polarity/chemotaxis; Nuclear receptor co-regulator; PHOSPHATASE; Phosphatase, lipid; Tumor suppressor P60484 5728 10q23.31 human K128-ac 470078 AIHCKAGkGRTGVMI molecular association, regulation; enzymatic activity, inhibited; phosphorylation cell cycle regulation; carcinogenesis, inhibited; signaling pathway regulation MTA1(INDUCES) 16829519; 25447541 3 0 0 decreases p-Akt at S473; regulation of PI3K/AKT pathway, reduced phosphorylation of Akt +STING1 STING Apoptosis; Endoplasmic reticulum; Membrane protein, integral; Membrane protein, multi-pass; Mitochondrial Q86WV6 340061 5q31.2 human Y240-p 1875847400 AGIKDRVySNSIYEL TMEM173 intracellular localization; phosphorylation transcription, induced 34933455 1 1 0 primes phosphorylation at S245 +FAF1 FAF1 Apoptosis; Nuclear receptor co-regulator Q9UNN5 11124 1p32.3 human S556-p 27996217 EREAIRLsLEQALPP protein degradation; molecular association, regulation; acetylation; ubiquitination; intracellular localization; phosphorylation transcription, induced; signaling pathway regulation GCN5(INDUCES) 30472208 1 3 0 induces de-aggregation of itself and ubiquitination and aggregation of MAVS, TBK1 and IRF3 phosphorylation and dimerization +PINX1 PINX1 Inhibitor; Nucleolus; Tumor suppressor Q96BK5 54984 8p23.1 human T317-p 14823404 EDATLEEtLVKKKKK protein degradation; ubiquitination 20573420 1 1 0 +EDNRA EDNRA GPCR, family 1; Membrane protein, integral; Membrane protein, multi-pass; Motility/polarity/chemotaxis; Receptor, GPCR P25101 1909 4q31.22-q31.23 human T403-p 2911712 TSVPMNGtSIQWKNH receptor desensitization, induced 24064210 1 1 0 Lack of S397, T403 and S404 influences desensitization to a greater extent compared than S391, S393, and T396 +PRKDC DNAPK DNA repair, damage; EC 2.7.11.1; KINASE; Kinase, protein; Nucleolus; Protein kinase, Ser/Thr (non-receptor); Protein kinase, atypical P78527 5591 8q11.21 human K3241-ac 11318517 CKFSMKMkMIDSARK FAT DNA repair, induced 27297111 1 3 5 regulates genomic stability and radiosensitivity of cells +Bcl2l1 Bcl-xL Apoptosis; Autophagy; Membrane protein, integral; Mitochondrial Q64373 12048 2 75.41 cM|2 H1 mouse S73-p 55588400 NGATGHSsSLDAREV apoptosis, induced 27239332 1 0 0 perinuclear clustering of mitochondria +TRIM32 TRIM32 EC 6.3.2.-; EC 6.3.2.19; Ligase; UBIQUITIN LIGASE; Ubiquitin conjugating system; Ubiquitin ligase Q13049 22954 9q33.1 human S335-p 3195095 SPEEVVAsPRASPAK intracellular localization cell growth, inhibited 25100564 1 25 0 promotes Asymmetric Cell Division +GLI1 GLI1 C2H2-type zinc finger protein; Oncoprotein; Transcription factor P08151 2735 12q13.3 human T374-p 457674 PGCTKRYtDPSSLRK zf-C2H2 intracellular localization; activity, inhibited transcription, altered 16293631 1 0 0 phosphorylation of this site inhibits the transport of GLI1 to the nucleus +DDB2 DDB2 DNA repair, damage Q92466 1643 11p11.2 human K35-ac 1876931102 LELEPEAkKLCAKGS DNA repair, induced 32789493 1 1 0 SIRT6 as a critical factor in the regulation of the process of UV-induced DNA damage repair +PPARA PPAR-alpha DNA-binding; Nuclear receptor; UBIQUITIN LIGASE Q07869 5465 22q13.31 human S280-p 1867858200 FHCCQCTsVETVTEL Hormone_recep activity, induced; molecular association, regulation transcription, induced RXRA(INDUCES) DNA(INDUCES) 30745182 1 1 0 +ATP7A ATP7A Apoptosis; Cell development/differentiation; Chaperone; EC 3.6.3.54; Hydrolase; Membrane protein, integral; Membrane protein, multi-pass; Transporter; Transporter, ion channel; Vesicle Q04656 538 Xq21.1 human S1432-p 4733392 QIGQKSPsEISVHVG intracellular localization 19576997 1 8 0 required for post-Golgi exocytic trafficking (Cu -responsive) +Plk4 PLK4 EC 2.7.11.21; KINASE; Kinase, protein; Nucleolus; Protein kinase, Other; Protein kinase, Ser/Thr (non-receptor) Q64702 20873 3|3 B mouse S285-p 12654000 TVEDSMDsGHATLST protein degradation; ubiquitination 20100909 1 1 0 +PRDX1 PRDX1 EC 1.11.1.15; Nuclear receptor co-regulator; Oxidoreductase Q06830 5052 1p34.1 human Y194-p 448924 DVQKSKEyFSKQK__ 1-cysPrx_C molecular association, regulation; intracellular localization; enzymatic activity, inhibited NOX1(INDUCES) 20178744 2 8 138 +Smad4 SMAD4 DNA-binding; Nuclear receptor co-regulator; Transcription, coactivator/corepressor P97471 17128 18 E2|18 49.51 cM mouse S367-p 1877718910 RFCLGQLsNVHRTEA MH2 intracellular localization carcinogenesis, inhibited 35895826 1 1 0 +Irf7 IRF7 DNA-binding; Transcription factor P70434 54123 7|7 F5 mouse S431-p 1276101 VSSLDSSsLGLCLSS transcription, induced DNA(INDUCES) 15743772 5 0 0 +Cryab CRYAB Chaperone; Heat shock protein P23928 25420 8q23 rat S45-p 448748 FSTATSLsPFYLRPP Crystallin protein degradation; intracellular localization; phosphorylation apoptosis, altered; cytoskeletal reorganization; signaling pathway regulation 12574148; 22870022; 24159092; 33220080 35 7 1 localization of phosphorylated alpha-BCs in the diabetic retina; regulates the dentritic functions of HspB5 +Trpc7 TRPC7 Channel, calcium; Membrane protein, integral; Membrane protein, multi-pass Q9WVC5 26946 13|13 B1 mouse T15-p 11164436 KNMQRRHtTLREKGR activity, inhibited 21402151 1 0 4 calcium influx inhibited +SIRT1 SIRT1 Apoptosis; DEACETYLASE; Deacetylase; EC 3.5.1.-; Nuclear receptor co-regulator Q96EB6 23411 10q21.3 human Y280-p 25311269 FRSRDGIyARLAVDF SIR2 molecular association, regulation transcription, inhibited STAT3(INDUCES) 29789426 1 0 1 +Fos Fos DNA-binding; Motility/polarity/chemotaxis; Oncoprotein; Transcription factor P01101 14281 12 D2|12 39.7 cM mouse K265-sm 3289000 SISNVELkAEPFDDF molecular association, regulation transcription, inhibited DNA(DISRUPTS) 23396363 2 3 0 +Gch1 GCH1 Cofactor and Vitamin Metabolism - folate biosynthesis; EC 3.5.4.16; Hydrolase P22288 29244 15p14 rat S72-p 487495 AYSSILRsLGEDPQR GTP_cyclohydroI enzymatic activity, induced 19762783 4 0 0 +ATP7A ATP7A Apoptosis; Cell development/differentiation; Chaperone; EC 3.6.3.54; Hydrolase; Membrane protein, integral; Membrane protein, multi-pass; Transporter; Transporter, ion channel; Vesicle Q04656 538 Xq21.1 human S1424-p 50479822 SYELPARsQIGQKSP protein stabilization; intracellular localization 29301787 1 1 1 translocation to membrane +GEM GEM G protein; G protein, monomeric; G protein, monomeric, RGK P55040 2669 8q22.1 human S23-p 2060100 QPQQQRWsIPADGRH protein stabilization; molecular association, regulation cytoskeletal reorganization; cell adhesion, altered 14-3-3 beta(INDUCES) 14701738 1 12 2 Mutation of either S23 or S289 inhibits binding to 14-3-3 +MAPRE2 RP1 Cytoskeletal Q15555 10982 18q12.1-q12.2 human S236-p 23140241 SSGSASKsDKDLETQ cell adhesion, inhibited 23844040 1 0 1 +H3C1 H3 DNA-binding P68431 8350 6p22.2 human K14-me 483043 ARKSTGGkAPRKQLA Histone transcription, induced 20093418 2 0 0 H3K9ac and H3K4 trimethylation were marked at the enhancer, while H3K46 was associated with the gene body where the RNA polymerase II occupied +ZWINT ZWINT Cell cycle regulation O95229 11130 10q21.1 human S262-p 20765003 MGRDPGVsFKAVGLQ Zwint molecular association, regulation; intracellular localization; phosphorylation cell cycle regulation ZW10(INDUCES) 21775627 1 1 0 inhibits phosphorylation of dynein and induces its recruitment with ZW10 to kinetochores, +TARDBP TDP-43 RNA-binding Q13148 23435 1p36.22 human K84-ac 50286964 YPKDNKRkMDETDAS intracellular localization 35264561 1 0 1 K84 nuclear-cytoplasmic trafficking +SNAP23 SNAP23 Vesicle O00161 8773 15q15.1-q15.2 human S23-p 9766096 ITDESLEsTRRILGL molecular association, regulation STX4(INDUCES) 12930825 1 5 1 +CASP3 CASP3 Apoptosis; EC 3.4.22.56; Motility/polarity/chemotaxis; Protease P42574 836 4q35.1 human T152-p 34488901 GDRCRSLtGKPKLFI Peptidase_C14 enzymatic activity, inhibited 29414778 1 0 0 +CSF3R GCSFR Membrane protein, integral; Receptor, cytokine Q99062 1441 1p34.3 human Y752-p 451834 GTSDQVLyGQLLGSP molecular association, regulation; phosphorylation cell differentiation, induced SOCS3(INDUCES); CISH(INDUCES) 12133942; 15470047; 17137800; 26296889 5 0 0 neutrophil development, Y752F mutant promoted monocyte development; decreases ERK phosphorylation +RCJMB04_5k17 CARD11 Adaptor/scaffold Q5F3W0 416476 chicken S668-p 457639 LERPFRPsVTSVGRI molecular association, regulation Bcl-10(INDUCES); MALT1(INDUCES) 18086859; 21157432 6 0 0 stimulates CBM complex formation, NF-kB activation and IL-2 or IFN-gamma production +BORA BORA Activator Q6PGQ7 79866 13q21.33 human S278-p 27724403 PISSPTFsPIEFQIG protein degradation; molecular association, regulation cell cycle regulation PIN1(INDUCES) 23442801; 23970419 2 2 0 required for mitotic entry +PICK1 PICK1 Adaptor/scaffold; Cell development/differentiation; Ligand, receptor tyrosine kinase Q9NRD5 9463 22q13.1 human S339-p 50642303 FQLQRLVsTMSKYYN Arfaptin molecular association, regulation GluR2(INDUCES) 26472923 1 0 0 S415 was essential for binding to GluA2 +PIK3C3 PIK3C3 Autophagy; Carbohydrate Metabolism - inositol phosphate; EC 2.7.1.137; Kinase, lipid; Motility/polarity/chemotaxis Q8NEB9 5289 18q12.3 human T668-p 14662701 ENLDLKLtPYKVLAT enzymatic activity, inhibited 20513426 1 0 0 +Bnip3l BNIP3L Apoptosis; Endoplasmic reticulum; Membrane protein, integral; Mitochondrial; Nuclear envelope Q9Z2F7 12177 14 D1|14 34.6 cM mouse S81-p 15719324 LLDAQHEsGQSSSRG BNIP3 autophagy, induced 28820284 1 4 0 mitophagy activity, neuroptrotective results in ischemic brains +ATG9A ATG9A Autophagy; Membrane protein, integral; Membrane protein, multi-pass; Vesicle Q7Z3C6 79065 2q35 human Y8-p 62382600 MAQFDTEyQRLEASY molecular association, regulation autophagy, induced AP1B1(INDUCES); AP1M2(INDUCES) 27934868 1 1 0 +Foxo1 FOXO1A DNA-binding; Nuclear receptor co-regulator; Oncoprotein; Transcription factor Q9R1E0 56458 3 C|3 23.19 cM mouse S326-p 448076 STISGRLsPIMTEQD molecular association, regulation; intracellular localization transcription, induced; transcription, inhibited DUSP6(INDUCES) 22503562; 22848439; 27875304 11 13 19 +CAV1 caveolin-1 Adaptor/scaffold; Motility/polarity/chemotaxis; Nuclear receptor co-regulator Q03135 857 7q31.2 human K39-ub 486852 MADELSEkQVYDAHT molecular association, regulation; intracellular localization UBXN6(INDUCES); VCP(INDUCES) 23335559 1 9 16 CAV1 ubiquitylation and binding to the VCP-UBXD1 complex and sorting into lysosomes +Cd200r1 CD200R Membrane protein, integral; Receptor, misc. Q9ES57 57781 16|16 B4 mouse Y286-p 458378 EEDEMQPyASYTEKS molecular association, regulation DOK2(INDUCES); DOK1(INDUCES) 16330532 1 1 2 +WNK4 WNK4 EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, Other; Protein kinase, Ser/Thr (non-receptor) Q96J92 65266 17q21.2 human Y1164-p 40407605 KKEIEDLySRLGKQP molecular association, regulation SHP-2(INDUCES) 25805816 1 1 0 SGK1-induced reversion of WNK4s ROMK inhibition +HADHA HADHA ACETYLTRANSFERASE; Acetyltransferase; Amino Acid Metabolism - lysine degradation; Amino Acid Metabolism - tryptophan; Amino Acid Metabolism - valine, leucine and isoleucine degradation; Carbohydrate Metabolism - butanoate; Carbohydrate Metabolism - propanoate; EC 1.1.1.211; EC 4.2.1.17; Lipid Metabolism - fatty acid; Lipid Metabolism - fatty acid elongation in mitochondria; Lipid Metabolism - unsaturated fatty acid biosynthesis; Lyase; Mitochondrial; Other Amino Acids Metabolism - beta-alanine; Oxidoreductase; Secondary Metabolites Metabolism - limonene and pinene degradation P40939 3030 2p23.3 human K383-ac 56842400 IAQVSVDkGLKTILK 3HCDH_N protein stabilization 27457618 2 0 0 3 sites can be acetylated or ubiquitylated, acetylation blocks ubiquitylation +TP73 p73 DNA-binding; Transcription factor; Tumor suppressor O15350 7161 1p36.32 human Y99-p 448428 SVPTHSPyAQPSSTF activity, induced; molecular association, regulation; ubiquitination apoptosis, induced; apoptosis, inhibited; transcription, induced; transcription, altered TIF1B(DISRUPTS); BUB3(INDUCES); PCQAP(INDUCES) 10391251; 20057499; 25893286 5 1 0 caspase-independent mitotic death (CIMD) ; PCQAP interacts with p73 only upon genotoxic stress, tumor suppressor and anti-metastatic functions +Ptprc CD45 EC 3.1.3.48; Membrane protein, integral; Motility/polarity/chemotaxis; PHOSPHATASE; Receptor protein phosphatase, tyrosine P06800 19264 1 E4|1 60.73 cM mouse S993-p 449973 SEPESDEsSDDDSDS Y_phosphatase enzymatic activity, induced 10066810 1 5 0 +TBXA2R TXA2-R iso2 GPCR, family 1; Membrane protein, integral; Membrane protein, multi-pass; Receptor, GPCR P21731-2 6915 19p13.3 human S145-p 469630 FSRPAVAsQRRAWAT 7tm_1 receptor desensitization, altered 16956790 2 0 0 +Ccdc88a girdin Actin-binding Q5SNZ0 108686 11|11 A3.3 mouse S237-p 4725935 SAQSPCGsPGMKRTE molecular association, regulation SLC3A2(INDUCES) 29538402 1 16 2 negatively regulates amino acid signaling +CDC42EP4 CDC42EP4 Cytoskeletal Q9H3Q1 23580 17q25.1 human S18-p 3212334 SVHSKRRsRADLTAE molecular association, regulation cell motility, induced; cytoskeletal reorganization CDC42(DISRUPTS); ARHGEF17(INDUCES); PARD6G(INDUCES) 25086031 1 11 0 ARHGEF-phosphoCEP4 interaction activates Rac, activated Rac increased filopodium formation +LLGL1 LLGL1 Cell adhesion; Cytoskeletal; Motility/polarity/chemotaxis Q15334 3996 17p11.2 human S663-p 449917 LKKSLRQsFRRIRKS intracellular localization 12725730; 34717957 3 16 8 +IL24 IL24 Motility/polarity/chemotaxis; Secreted; Secreted, signal peptide Q13007 11009 1q32.1 human S88-p 41122601 QAQDNITsARLLQQE activity, induced; intracellular localization cell cycle regulation; carcinogenesis, inhibited; cell growth, inhibited; cell motility, inhibited; signaling pathway regulation 26009991 1 0 0 IL24 maturation and secretion; activates Caspase-9, PARP, and JNK; inhibits the AKT signaling pathway +PSTPIP2 PSTPIP2 Actin-binding Q9H939 9050 18q21.1|tdb7990 human Y329-p 465051 NYSLVDDySLLYQ__ molecular association, regulation SHIP(INDUCES) 26304991 1 1 1 +Epha4 EphA4 EC 2.7.10.1; KINASE; Kinase, protein; Membrane protein, integral; Protein kinase, TK; Protein kinase, tyrosine (receptor) Q03137 13838 1 C4|1 39.55 cM mouse Y602-p 450857 TYVDPFTyEDPNQAV EphA2_TM enzymatic activity, induced cell motility, altered; cytoskeletal reorganization 10848605; 16102535 7 16 155 YY->EE mutation induced receptor clustering that induced growth cone collapse and axonal guidance problems.; in vitro +GH1 GH Hormone; Secreted; Secreted, signal peptide P01241 2688 17q23.3 human K141-ub 1881839500 SNVYDLLkDLEEGIQ protein degradation 34200910 1 1 0 K141R mutant increases its half-life and increase in half-life occurs in the bloodstream +LAT LAT iso2 Adaptor/scaffold; Membrane protein, integral O43561-2 27040 16p11.2 human K52-ub 31914109 YPRGIQFkRPHTVAP LAT protein degradation; ubiquitination 27221712 2 1 0 Y132 phosphorylation is required for ubiquitylation. +Eif2ak3 PERK EC 2.7.11.1; KINASE; Kinase, protein; Membrane protein, integral; Protein kinase, Other; Protein kinase, Ser/Thr (non-receptor); Translation Q9Z2B5 13666 6|6 C1 mouse Y561-p 30310301 QCQTESKyDSVSADV molecular association, regulation; activity, inhibited apoptosis, inhibited NCK1(INDUCES); NCK2(INDUCES) 24371088; 29941454 2 0 0 inhibits its activity and signaling; enhances insulin secretion and production +LRRC4C LRRC4C Cell development/differentiation; Membrane protein, integral Q9HCJ2 57689 11p12 human S631-p 3893278 PLLIRMNsKDNVQET molecular association, regulation PSD-95(INDUCES) 22922712 1 4 4 dendritic spine morphogenesis +NR4A1 Nur77 Apoptosis; DNA-binding; Nuclear receptor P22736 3164 12q13.13 human S95-p 471072 TSSSSATsPASASFK protein degradation; protein stabilization; molecular association, regulation; activity, inhibited cell cycle regulation; transcription, altered PIN1(INDUCES) DNA(DISRUPTS) 17023523; 22002310 2 0 0 required for cell proliferation; Phosphorylation inhibits transcription. +Pax6 PAX6 DNA-binding; Motility/polarity/chemotaxis; Transcription factor P63015 18508 2 E3|2 55.31 cM mouse T304-p 458809 QPIPQPTtPVSSFTS transcription, induced 16407227 1 0 1 +ERG ERG DNA-binding; Oncoprotein; Transcription factor P11308 2078 21q22.2 human T180-p 1870421703 KDDFQRLtPSYNADI SAM_PNT protein degradation; molecular association, regulation; ubiquitination carcinogenesis, inhibited; cell growth, inhibited; transcription, inhibited FBXW7(INDUCES) 32871104 1 0 0 +Brca1 BRCA1 EC 6.3.2.-; Nuclear receptor co-regulator; Transcription, coactivator/corepressor; Tumor suppressor; UBIQUITIN LIGASE; Ubiquitin conjugating system; Ubiquitin ligase P48754 12189 11 65.18 cM|11 D mouse S971-p 448526 QSVSPIRsSIKTDNR cell cycle regulation; DNA repair, induced 15485917; 35409089 10 0 0 +SLC40A1 SLC40A1 Membrane protein, integral; Membrane protein, multi-pass; Transporter; Transporter, SLC family Q9NP59 30061 2q32.2 human Y538-p 25589100 VAMGHIMyFRFAQNT TM receptor internalization, inhibited 22682226 1 0 0 regulates internalization partially but not hepcidin mediated internalization +NCOA3 SRC-3 ACETYLTRANSFERASE; Acetyltransferase; EC 2.3.1.48; Motility/polarity/chemotaxis; Nuclear receptor co-regulator; Transcription, coactivator/corepressor Q9Y6Q9 8202 20q13.12 human K723-ub 1505897100 CGDGNVVkQEQLSPK DUF4927 activity, induced; protein degradation; molecular association, regulation; ubiquitination transcription, induced; signaling pathway regulation ER-alpha(INDUCES) 17574025 1 0 0 +LLGL1 LLGL1 Cell adhesion; Cytoskeletal; Motility/polarity/chemotaxis Q15334 3996 17p11.2 human S673-p 449918 RIRKSRVsGKKRAAN intracellular localization 34717957 2 1 0 +CIRBP CIRBP RNA-binding; Spliceosome; Translation Q14011 1153 19p13.3 human S146-p 3891206 RDYYSSRsQSGGYSD intracellular localization 29432179 1 4 34 may be cause of its exclusion from the DNA-damaged regions +Notch1 Notch 1 Membrane protein, integral; Motility/polarity/chemotaxis; Oncoprotein; Receptor, misc.; Transcription factor Q01705 18128 2 A3|2 18.91 cM mouse S1791-p 35502500 LKPLKNAsDGALMDD intracellular localization cell differentiation, inhibited; transcription, induced 24662486 1 1 0 localized from cell surface to endosomes in the inactivated Notch 1 state, and from endosomes to the nucleus in the Notch 1 activated state; increased production of NICD +PRKAR1A PKAR1A Protein kinase, regulatory subunit P10644 5573 17q24.2 human S101-p 454354 RRRRGAIsAEVYTEE enzymatic activity, induced 29378851 2 2 0 PKACA enzymatic activity +NFKB1 NFkB-p105 DNA-binding; Transcription factor P19838 4790 4q24 human S337-p 449967 FVQLRRKsDLETSEP RHD_dimer transcription, altered 12947093; 17959673 5 1 0 required for DNA binding and transactivation +CD274 PD-L1 Membrane protein, integral Q9NZQ7 29126 9p24.1 human S184-p 63237405 GKTTTTNsKREEKLF C2-set_2 protein degradation; ubiquitination 27572267 1 0 0 +SYMPK Symplekin Motility/polarity/chemotaxis; RNA processing Q92797 8189 19q13.32 human K361-sm 2586340 DSTLKKMkLEPNLGE RNA splicing, altered; cell growth, induced 17923699 1 4 0 regulation of mRNA 3'-end processing- cleavage and polyadenylation +SNCA SNCA Adaptor/scaffold P37840 6622 4q22.1 human T64-p 1876998407 EKTKEQVtNVGGAVV Synuclein molecular association, regulation; intracellular localization transcription, altered SNCA(DISRUPTS) 37252975 1 2 0 +CTNND2 CTNND2 Actin-binding; Motility/polarity/chemotaxis Q9UQB3 1501 5p15.2 human T457-p 480958 TGTYRTStAPSSPGV phosphorylation cell motility, induced; cell growth, induced; signaling pathway regulation 34069970 2 2 0 induces phosphorylation of p21, regulates AKT/d-catenin/p21 signalling +STING1 STING Apoptosis; Endoplasmic reticulum; Membrane protein, integral; Membrane protein, multi-pass; Mitochondrial Q86WV6 340061 5q31.2 human K338-ac 1881818300 RHLRQEEkEEVTVGS protein degradation autophagy, induced; signaling pathway regulation beclin 1(INDUCES); STING(DISRUPTS) 37081450 1 1 0 Beclin1 mediated acetylation of STING, inhibits STING signal transduction, dimerization of STING +Baz2a BMZF-2 DNA-binding; Nucleolus; Transcription regulation Q91YE5 116848 10|10 D3 mouse K672-ac 8537513 RGRPPKIkMPELLNK molecular association, regulation transcription, inhibited RNA(DISRUPTS) 19578370 1 1 0 +IQCB1 IQCB1 Cell development/differentiation Q15051 9657 3q13.33|3q21.1 human K263-ub 21177000 GLRRLLSkQETGTEF intracellular localization cell cycle regulation; cytoskeletal reorganization 28498859 1 4 0 regulation of cilia formation +RPL11 RPL11 Motility/polarity/chemotaxis; Nucleolus; Ribosomal; Translation P62913 6135 1p36.11 human K144-ne 12067606 PGFSIADkKRRTGCI Ribosomal_L5_C protein stabilization; intracellular localization 19713960 1 0 0 +CERS6 LASS6 DNA-binding; Membrane protein, integral; Membrane protein, multi-pass Q6ZMG9 253782 2q24.3 human S347-p 22350312 RSDIESSsDEEDSEP enzymatic activity, induced 26887952 1 3 0 +NR1H4 NR1H4 DNA-binding; Nuclear receptor Q96RI1 9971 12q23.1 human Y77-p 1186568001 QISSSSYySNLGFYP molecular association, regulation; intracellular localization transcription, induced RXRA(INDUCES) 29968724 2 1 0 regulates response to cholestasis and bile acid levels, regulates gene expression +BSG BSG iso2 Immunoglobulin superfamily; Membrane protein, integral P35613-2 682 19p13.3 human S246-p 471136 LDDDDAGsAPLKSSG activity, inhibited; phosphorylation carcinogenesis, inhibited; cell growth, inhibited; cell motility, inhibited; signaling pathway regulation 31016558 1 36 0 inhibits Akt phosphorylation; decrease/inhibits STAT3 and Akt signaling +GRIN2A NMDAR2A Channel, ligand-gated; Membrane protein, integral; Membrane protein, multi-pass Q12879 2903 16p13.2 human Y1105-p 4109553 CSEVERTyLKTKSSS NMDAR2_C activity, induced 10195142 3 1 12 potentiation of receptor currents mediated by Src +CACB CACNA1C Channel, calcium; Membrane protein, integral; Membrane protein, multi-pass P15381 100101555 rabbit S1928-p 455278 ASLGRRAsFHLECLK CAC1F_C activity, induced; activity, inhibited 16648185; 20937253 31 3 0 +STARD3 STARD3 Membrane protein, integral; Membrane protein, multi-pass Q14849 10948 17q12 human S203-p 1876567502 LLFSGALsEGQFYSP MENTAL molecular association, regulation VAPA(INDUCES) 35231443 1 0 0 +MRE11 MRE11A Cell cycle regulation; DNA repair, damage; DNA-binding; Deoxyribonuclease P49959 4361 11q21 human R570-m2 62978403 SAATNKGrGRGRGRR DNA repair, altered 15741314 0 1 0 +PAK6 PAK6 EC 2.7.11.1; KINASE; Kinase, protein; Nuclear receptor co-regulator; Protein kinase, STE; Protein kinase, Ser/Thr (non-receptor) Q9NQU5 56924 15q15.1 human T99-p 3843654 LSVISSNtLRGRSPT molecular association, regulation; intracellular localization 14-3-3 sigma(INDUCES) 35969127 2 2 4 +Pak1 PAK1 EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, STE; Protein kinase, Ser/Thr (non-receptor) P35465 29431 1q32 rat S21-p 448174 APPMRNTsTMIGAGS molecular association, regulation NCK1(DISRUPTS) 10805734 3 0 10 +MITF MITF DNA-binding; Oncoprotein; Transcription factor O75030 4286 3p13 human S516-p 450265 KTSSRRSsMSMEETE DUF3371 protein degradation; molecular association, regulation; intracellular localization cell growth, inhibited; transcription, induced; transcription, inhibited ID4(INDUCES); 53BP1(INDUCES) 27702651 8 5 0 induces p21Cip1 expression; reduces TYR expression; cell proliferation arrest and senescence +RELA NFkB-p65 DNA-binding; Nuclear receptor co-regulator; Transcription factor Q04206 5970 11q13.1 human T305-gl 27490900 IEEKRKRtYETFKSI O-GlcNAc glycosylation; acetylation transcription, induced 23027940; 28416608 2 1 0 +CD19 CD19 Cell surface; Membrane protein, integral P15391 930 16p11.2 human Y439-p 469560 LSQDGSGyENPEDEP activity, induced; molecular association, regulation; phosphorylation PLCG2(INDUCES); VAV1(INDUCES) 10706702 1 0 0 ERK2 phosphorylation; Ca(2+) influx +SLC4A1 SLC4A1 Membrane protein, integral; Membrane protein, multi-pass; Transporter; Transporter, SLC family P02730 6521 17q21.31 human Y8-p 451570 MEELQDDyEDMMEEN molecular association, regulation LYN(INDUCES); ANK1(DISRUPTS) 10942405; 27856737 8 18 8 +SLC9A5 NHE5 Membrane protein, integral; Membrane protein, multi-pass; Transporter; Transporter, SLC family Q14940 6553 16q22.1 human S712-p 20832301 EEEESDSsETEKEDD molecular association, regulation; activity, inhibited endocytosis, induced ARRB1(INDUCES) 21296876 1 0 0 +RBL1 Rb-like 1 Transcription, coactivator/corepressor; Tumor suppressor P28749 5933 20q11.23 human S1009-p 27460997 LLYKFNGsPSKSLKD Rb_C molecular association, regulation E2F1(DISRUPTS) 28439018 1 5 0 +WAS WASP Adaptor/scaffold; Motility/polarity/chemotaxis P42768 7454 Xp11.23 human K144-sm 52504002 FRALVQEkIQKRNQR WH1 molecular association, regulation; acetylation transcription, altered; signaling pathway regulation COMMD1(DISRUPTS); HDAC6(DISRUPTS) 26261240 1 0 0 induces hypoacetylation at H3K14, regulates NF-kB signaling +Stub1 CHIP Adaptor/scaffold; EC 6.3.2.-; EC 6.3.2.19; Ligase; UBIQUITIN LIGASE; Ubiquitin conjugating system; Ubiquitin ligase Q9WUD1 56424 17 A3.3|17 12.93 cM mouse S20-p 453857 LGTGGGGsPDKSPSA molecular association, regulation; enzymatic activity, induced apoptosis, induced IL32(DISRUPTS) 26206088; 29111393 3 98 9 IL32-induced neuronal cell death; tAIF-mediated cell death in rotenone-treated cortical neurons, dysregulated Cdk5 activation +CDC6 CDC6 Cell cycle regulation Q99741 990 17q21.2 human S106-p 450916 DNQLTIKsPSKRELA protein stabilization; molecular association, regulation; intracellular localization cell cycle regulation CDH1(DISRUPTS) 10339564; 16153703; 19343071; 22179839 6 3 2 +Elk1 ELK1 DNA-binding; Transcription factor P41969 13712 X A1.3|X 16.45 cM mouse S390-p 449757 LSPIAPRsPAKLSFQ molecular association, regulation; intracellular localization cell differentiation, altered; transcription, induced; cytoskeletal reorganization; transcription, altered; cell growth, altered MED16(INDUCES); MED23(INDUCES); Trap100(INDUCES) DNA(INDUCES) 18160653; 18356083; 27738173; 35082159; 7889942 10 0 0 +Myocd myocardin Cell development/differentiation; Transcription factor Q8VIM5 214384 11|11 B3 mouse S624-p 3627505 GQTHVLSsTFLSPQC transcription, inhibited 16141410 1 0 0 +Vcpip1 VCIP135 Cell cycle regulation; DEUBIQUITINASE; EC 3.4.19.12; Protease; Ubiquitin conjugating system; Ubiquitin-specific protease Q8CF97 286761 5q11 rat S130-p 40642201 NYHCKLLsPILARYG VCIP135_N enzymatic activity, inhibited 25904330 1 3 0 regulates Golgi structure formation, attenuates golgi mrmbrane fusion +Erbb2 HER2 EC 2.7.10.1; KINASE; Kinase, protein; Membrane protein, integral; Oncoprotein; Protein kinase, TK; Protein kinase, tyrosine (receptor) P06494 24337 10q31 rat Y1114-p 448674 DLSPLQRySEDPTLP molecular association, regulation EGFR(INDUCES) 15163624 8 2 1 +DROSHA DROSHA EC 3.1.26.3; Nucleolus; RNA processing; RNA-binding; Ribonuclease Q9NRR4 29102 5p13.3 human S302-p 14572633 RDNRRSPsLERSYKK intracellular localization 20554852; 21674040 2 11 0 nuclear localization +GBA1 GBA EC 3.2.1.45; Glycan Metabolism - other glycan degradation; Hydrolase; Lipid Metabolism - sphingolipid P04062 2629 1q22 human K332-ub 1881371304 LLLPHWAkVVLTDPE protein degradation 34644545 1 1 0 K332R mutant has normal GBA activity; GBA impairment, a major cause in PD; premature degradation, and subsequent accumulation of alpha-synuclein +Abl1 Abl EC 2.7.10.2; KINASE; Kinase, protein; Oncoprotein; Protein kinase, TK; Protein kinase, tyrosine (non-receptor) P00520 11350 2 21.86 cM|2 B mouse Y232-p 450302 IYGVSPNyDKWEMER activity, induced 12149456 3 6 255 +Zbed3 ZBED3 DNA-binding Q9D0L1 72114 13|13 D1 mouse S111-p 6738702 MPCPPPPsPTMAAEG molecular association, regulation axin 1(INDUCES) 19141611 1 0 0 interaction beween ZBED3 and axin is important for ZBED3 to inhibit beta catenin (CTNNB1) phosphorylation by GSK3 beta ; activates Wnt signaling +L1CAM NCAM-L1 Cell adhesion; Membrane protein, integral P32004 3897 Xq28 human Y1176-p 456529 KDETFGEyRSLESDN Bravo_FIGEY molecular association, regulation; intracellular localization; phosphorylation cell adhesion, inhibited ANK3(INDUCES); AP2M1(NOT_REPORTED); AP2M1(DISRUPTS) 12082080; 19720049; 29109170; 9570805; 9651214 12 3 10 L1 sensitivity to ethanol +Sstr3 SSTR3 GPCR, family 1; Membrane protein, integral; Membrane protein, multi-pass; Receptor, GPCR P30936 171044 7q34 rat S346-p 456709 RPSRRVRsQEPGSGP receptor desensitization, altered; receptor internalization, altered 9295322 1 0 1 +ELK1 ELK1 DNA-binding; Transcription factor P19419 2002 Xp11.23 human S389-p 449757 LSPIAPRsPAKLSFQ activity, induced; protein conformation transcription, induced; transcription, altered 11145955; 8262053; 9130707 10 0 0 +Ripk1 RIPK1 EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, Ser/Thr (non-receptor); Protein kinase, TKL Q60855 19766 13 A3.3|13 14.01 cM mouse Y383-p 451864 KLQEEASyHAFGIFA molecular association, regulation; enzymatic activity, inhibited; phosphorylation apoptosis, inhibited MAPKAPK2(INDUCES) 36329033 1 9 290 induces MK2 phosphorylation +Jund JunD Motility/polarity/chemotaxis; Transcription factor P15066 16478 8 B3.3|8 34.15 cM mouse S90-p 473544 APDGLLAsPDLGLLK Jun transcription, altered 14676207 1 12 2 +IRS1 IRS1 Adaptor/scaffold; Motility/polarity/chemotaxis P35568 3667 2q36.3 human T525-p 27532989 DNRFRKRtHSAGTSP intracellular localization 34253290 1 3 0 disassociation of IRS2 from plasma membrane to cytosol; limits PM-associated PI3K and PIP3 synthesis +NANOG NANOG Cell development/differentiation; DNA-binding; Transcription factor Q9H9S0 79923 12p13.31 human T200-p 28070707 LPMWSNQtWNNSTWS protein stabilization; molecular association, regulation carcinogenesis, induced; cell motility, induced; cell growth, induced; transcription, induced; signaling pathway regulation p300(INDUCES); NANOG(INDUCES) DNA(INDUCES) 23708658; 30728896 3 1 0 5-Lox mediated signaling +HIF1A HIF1A Autophagy; DNA-binding; Transcription factor Q16665 3091 14q23.2 human S451-p 31877647 QNINLAMsPLPTAET protein stabilization; molecular association, regulation; ubiquitination carcinogenesis, induced; cell motility, induced; cell growth, induced; transcription, induced EGLN1(DISRUPTS); VHL(DISRUPTS); PIN1(INDUCES) 33550096 2 7 0 inhibits ubiquitination +MYC Myc DNA-binding; Nucleolus; Oncoprotein; Transcription factor P01106 4609 8q24.21 human S388-p 450961 RRNELKRsFFALRDQ HLH molecular association, regulation carcinogenesis, inhibited; cell growth, inhibited; cell differentiation, induced; transcription, induced MAX(DISRUPTS) DNA(INDUCES); DNA(DISRUPTS) 22020439; 25326649; 26678338 8 0 0 repression of YAP/TAZ activity +BAX BAX Apoptosis; Membrane protein, integral; Mitochondrial; Tumor suppressor Q07812 581 19q13.33 human S163-p 469571 GGWDGLLsYFGTPTW activity, induced; intracellular localization apoptosis, induced 15525785; 17911107 2 0 0 +TFEB TFEB DNA-binding; Transcription factor P19484 7942 6p21.1 human K274-ac 1878278901 DLDVRWNkGTILKAS molecular association, regulation autophagy, inhibited; transcription, inhibited TFEB(DISRUPTS) DNA(DISRUPTS) 31750630 1 0 0 suppresses TFEB transcriptional activity, knocking down dGcn5 in Drosophila eyes reduced hTau aggregation +ETV4 ETV4 DNA-binding P43268 2118 17q21.31 human Y392-p 5231710 KNRPAMNyDKLSRSL Ets intracellular localization cell motility, induced; transcription, induced 36670069 2 2 11 promotes lymph node metastasis of BCa cells +DACH1 DACH1 DNA-binding; Motility/polarity/chemotaxis; Transcription factor Q9UI36 1602 13q21.33 human S581-p 478242 EKDETPLsTPTARDS intracellular localization; activity, inhibited translation, inhibited 24335958 1 4 1 Repression of Snail 5' UTR-Luc reporter +Mapk1 ERK2 EC 2.7.11.24; KINASE; Kinase, protein; Protein kinase, CMGC; Protein kinase, Ser/Thr (non-receptor) P63086 116590 11q23 rat S27-p 7989100 GPRYTNLsYIGEGAY Pkinase molecular association, regulation; enzymatic activity, induced MEK2(INDUCES); MEK1(INDUCES) 19447520 1 0 0 +FBXL7 FBXL7 UBIQUITIN LIGASE; Ubiquitin ligase Q9UJT9 23194 5p15.1 human K109-ub 40320200 RLASRPQkEQASIDR protein degradation cell cycle regulation; apoptosis, inhibited 25654763 1 0 0 +Cavin1 PTRF Transcription initiation complex O54724 19285 11 D|11 63.95 cM mouse S368-p 452129 TDLLRGSsPDVHTLL phosphorylation 21282370 2 28 28 regulates phosphorylation of HSL S557 (aka S563) and S651 (aka S660); regulates lipolysis in adipocytes +GHR GH receptor Membrane protein, integral; Receptor, cytokine P19941 100009325 rabbit Y534-p 486256 NFIMDNAyFCEADAK GHBP molecular association, regulation STAT5A(INDUCES); STAT5B(INDUCES) 17666591 3 0 0 +Map1b MAP1B Cytoskeletal; Motility/polarity/chemotaxis P15205 29456 2q12 rat T2412-p 1172732404 WGSNMQVtLIPTHDS molecular association, regulation STX17(INDUCES) 29925525 1 0 0 starvation-induced dephosphorylation allows STX17 to dissociate from MAP1B and bind to ATG14 +GMNN Geminin Cell cycle regulation; Motility/polarity/chemotaxis O75496 51053 6p22.3 human K100-ub 964516696 NPSSQYWkEVAEKRR Geminin molecular association, regulation CDT1(DISRUPTS) 34599168 1 2 0 inhibits MCM proteins binding to Cdt1; cancer-derived SPOP mutants increase replication origin ?ring, re-replication, and genome instability, increased by ATR inhibition +XRCC5 Ku80 DNA-binding; EC 3.6.1.-; EC 3.6.4.-; Helicase; Nuclear receptor co-regulator; Nucleolus; RNA-binding P13010 7520 2q35 human K543-ub 12250514 LFPLIEAkKKDQVTA Ku_C molecular association, regulation DNA repair, induced DNA(DISRUPTS) 27895153 1 3 6 +CYP21A2 CYP21A2 EC 1.14.99.10; Lipid Metabolism - C21-steroid hormone; Oxidoreductase P08686 1589 6p21.33 human S490-p 1410340100 PRGMGAHsPGQSQ__ enzymatic activity, altered 30580688 1 1 0 Regulate steroidogenic enzyme activity +KIF2C KIF2C Cancer Testis Antigen (CTA); Microtubule-binding; Motility/polarity/chemotaxis; Motor Q99661 11004 1p34.1 human T537-p 14157500 LGQNKAHtPFRESKL Kinesin intracellular localization; activity, inhibited cell cycle regulation; cytoskeletal reorganization 20368358; 29230353 2 0 0 microtubule end does not accelerate ADP dissociation; reduced microtubule depolymerization activity and reduced microtubule-stimulated ATPase activity; abolishes long microtubule end residence events +TBK1 TBK1 EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, Other; Protein kinase, Ser/Thr (non-receptor) Q9UHD2 29110 12q14.2 human K372-ub 27492600 RLAQHFPkTTEENPI TBK1_ULD protein degradation 32366851 2 3 0 K48-linked polyubiquitination and degradation of TBK1 +CGAS cGAS EC 2.7.7.86 Q8N884 115004 6q13 human K384-ub 964506174 LSFSHIEkEILNNHG Mab-21 protein degradation autophagy, induced 36343628 1 2 0 +CTDP1 CTDP1 EC 3.1.3.16; Motility/polarity/chemotaxis; PHOSPHATASE; Protein phosphatase, Ser/Thr (non-receptor); Transcription initiation complex Q9Y5B0 9150 18q23 human S942-p 455466 SSNEDEGsSSEADEM FCP1_C molecular association, regulation; enzymatic activity, induced transcription, altered GTF2F1(INDUCES) 15723518; 19215094 2 0 1 +ARHGDIA RhoGDI alpha Apoptosis; Cell adhesion; Cell development/differentiation; G protein regulator, misc.; Motility/polarity/chemotaxis P52565 396 17q25.3 human K141-ac 461817 RKGVKIDkTDYMVGS Rho_GDI cytoskeletal reorganization 16916647 1 7 3 +APP APP iso4 Apoptosis; Cell surface; Membrane protein, integral; Receptor, misc.; Transcription factor P05067-4 351 21q21.3 human S206-p 450332 ADAEEDDsDVWWGGA intracellular localization 8999878 1 2 0 APP was phosphorylated within the post Golgi as well as on the cell surface. +NFATC4 NFAT3 DNA-binding; Transcription factor Q14934 4776 14q12 human S217-p 953803 GLGSPLPsPRASPRP transcription, induced 17875713 1 16 1 +KCNE3 KCNE3 Channel, potassium Q9Y6H6 10008 11q13.4 human S82-p 460569 LILGYTRsRKVDKRS ISK_Channel activity, induced; activity, inhibited 16449802; 21911611 2 0 0 KCNE3-S82A channels was not altered in the presence of E2; S82A rundown much more rapidly than the non-mutated channels; controls KCNE3-Kv3.4 channel opening +Acaca ACC1 Carbohydrate Metabolism - propanoate; Carbohydrate Metabolism - pyruvate; EC 6.3.4.14; EC 6.4.1.2; Ligase; Lipid Metabolism - fatty acid biosynthesis P11497 60581 10q26 rat S77-p 448291 LAFHMRSsMSGLHLV enzymatic activity, inhibited 7915280 8 4 0 +CLASP2 CLASP2 Cytoskeletal; Motility/polarity/chemotaxis O75122 23122 3p22.3 human S1053-p 14159685 DQFPDDLsLDHSDLV cell cycle regulation 23045552 1 3 0 +ACTB ACTB Cytoskeletal; Motility/polarity/chemotaxis P60709 60 7p22.1 human K50-ac 461691 VMVGMGQkDSYVGDE Actin molecular association, regulation CAP2(INDUCES); INF2(INDUCES) 31871199 2 5 58 acetyl-mimetic actin mutants inhibit INF2-mediated actin polimerization, CAP/Ac-actin binds INF2-DAD +DACH1 DACH1 DNA-binding; Motility/polarity/chemotaxis; Transcription factor Q9UI36 1602 13q21.33 human S493-p 4782166 ERVPDSPsPAPSLEE intracellular localization; activity, inhibited translation, inhibited 24335958 1 6 0 Repression of Snail 5' UTR-Luc reporter +TRIM32 TRIM32 EC 6.3.2.-; EC 6.3.2.19; Ligase; UBIQUITIN LIGASE; Ubiquitin conjugating system; Ubiquitin ligase Q13049 22954 9q33.1 human K50-ub 41497066 ICRQCLEkLLASSIN zf-RING_UBOX protein degradation; intracellular localization autophagy, induced 33999923 1 2 0 +Vamp2 VAMP2 Membrane protein, integral; Motility/polarity/chemotaxis; Vesicle P63044 22318 11|11 B3 mouse T35-p 12473004 SNRRLQQtQAQVDEV Synaptobrevin molecular association, regulation ATM(INDUCES) 19962314 1 0 0 complex of ATM, VAMP2, ATR and SYN1 +Dync1li2 DNCLI2 Motility/polarity/chemotaxis Q62698 81655 19p14 rat S194-p 452544 PEEGCQGsPQRRGPL DLIC cell cycle regulation; cytoskeletal reorganization 32467330 1 68 5 +Calm1 Calmodulin Calcium-binding; Protein phosphatase, regulatory subunit P0DP29 24242 6q32 rat Y100-p 448707 FDKDGNGyISAAELR EF-hand_7 activity, induced; protein stabilization 25830911 5 75 2115 +YAP1 YAP1 Oncoprotein; Transcription, coactivator/corepressor P46937 10413 11q22.1 human S94-p 3253276 RLRKLPDsFFKPPEP molecular association, regulation cell growth, induced; cell growth, inhibited; transcription, induced; transcription, inhibited TEAD1(DISRUPTS) 25751140; 27144834 8 3 3 +NANOG NANOG Cell development/differentiation; DNA-binding; Transcription factor Q9H9S0 79923 12p13.31 human Y35-p 25240301 ICGPEENyPSLQMSS activity, induced carcinogenesis, induced; cell motility, induced; cell growth, induced 22493428 1 0 0 increased lamellipodia and filopodia formation and increased cell polarization +HSPA9 HSPA9B Chaperone; Heat shock protein; Nucleolus P38646 3313 5q31.2 human T62-p 483967 VVGIDLGtTNSCVAV HSP70 protein stabilization 17573779 1 0 0 ; phosphorylation of this site stabilizes HSPA9B, activates TTK and promotes centrosome re-duplication +Rock2 ROCK2 EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, AGC; Protein kinase, Ser/Thr (non-receptor) Q62868 25537 6q16 rat Y722-p 464192 LADKNKIyESIEEAK enzymatic activity, inhibited 35889443 5 7 127 protects against hypoxia-reoxygenation (H/R) injury in response to hydrogen sulfide +CENPA CENPA DNA-binding P49450 1058 2p23.3 human K124-ub 40439801 GRVTLFPkDVQLARR Histone protein degradation; molecular association, regulation; ubiquitination; intracellular localization cell cycle regulation HJURP(INDUCES) 25727006; 31550462; 34758320 5 2 0 ubquitylation is required for viability, CENP-A K124R mutant is lethal, EYFP-CENP-A K124R induces additional ubiquitylation and binds HJURP. ; Ser68 facilitates degradation; induces CENPA localization/deposition at centromeres +Dab1 DAB1 Adaptor/scaffold P97318 13131 4 C6|4 47.79 cM mouse Y232-p 447961 SQKKEGVyDVPKSQP molecular association, regulation; intracellular localization neural plasticity; cell differentiation, induced; cell motility, altered; cell adhesion, altered; cytoskeletal reorganization Src(INDUCES); CRKL(INDUCES); SOCS1(INDUCES); NCK2(INDUCES); PIK3R1(INDUCES) 14517291; 15062102; 15091337; 19796633; 22586277 13 5 12 alternatively spliced variants +EIF4G1 eIF4G RNA-binding; Translation; Translation initiation Q04637 1981 3q27.1 human S1231-p 449798 EAALPPVsPLKAALS molecular association, regulation cell cycle regulation; translation, inhibited Mnk1(INDUCES); EIF4A1(INDUCES) RNA(DISRUPTS) 24248602 6 88 59 +GLI2 GLI2 C2H2-type zinc finger protein; Oncoprotein; Transcription factor P10070 2736 2q14.2 human S149-p 10414536 ISAARGLsPADVAQE molecular association, regulation; acetylation; intracellular localization carcinogenesis, induced; cell motility, induced; transcription, induced SNIP1(DISRUPTS) RNA(DISRUPTS) 25416949 1 4 0 CCL21 treatment, nuclear translocation +ADRB2 ADRB2 GPCR, family 1; Membrane protein, integral; Membrane protein, multi-pass; Receptor, GPCR P07550 154 5q32 human Y350-p 449808 RRSSLKAyGNGYSSN receptor internalization, induced 19864009 8 0 0 +XRCC5 Ku80 DNA-binding; EC 3.6.1.-; EC 3.6.4.-; Helicase; Nuclear receptor co-regulator; Nucleolus; RNA-binding P13010 7520 2q35 human K282-ub 15391475 TWTVVDAkTLKKEDI Ku molecular association, regulation DNA repair, induced DNA(DISRUPTS) 27895153 1 7 5 +PLK1 PLK1 EC 2.7.11.21; KINASE; Kinase, protein; Protein kinase, Other; Protein kinase, Ser/Thr (non-receptor) P53350 5347 16p12.2 human K492-ub 21181662 YMSEHLLkAGANITP molecular association, regulation; intracellular localization cell cycle regulation BUB1B(DISRUPTS); INCENP(DISRUPTS) 23455478 2 4 0 regulates PLK1 dissociation from kinetochores and anaphase onset +Dmbt1 DMBT1 Membrane protein, integral; Oncoprotein; Secreted; Secreted, signal peptide; Tumor suppressor Q60997 12945 7|7 F3 mouse T2073-p 13201902 AFTLGRRtHIDRGQP molecular association, regulation exocytosis, altered; cytoskeletal reorganization NHERF(INDUCES); ACTB(INDUCES) 15146979 1 0 0 Phosphomimetic peptides associate with the cytoskeleton, though not binding directly to actin. +SRSF2 SFRS2 RNA processing; RNA splicing; Spliceosome Q01130 6427 17q25.1 human K52-ac 20842100 IPRDRYTkESRGFAF RRM_1 protein degradation; ubiquitination cell cycle regulation; RNA splicing, inhibited; apoptosis, inhibited 21157427 1 1 0 inhibits ubiquitination, regulates SRPK1/SRPK32 localization inhibiting its phosphorylation and apoptosis +FBXO46 FBX46 UBIQUITIN LIGASE; Ubiquitin conjugating system; Ubiquitin ligase Q6PJ61 23403 19q13.32 human S67-p 1261736703 LATEVPAsQPAPLLS protein degradation 30171069 1 0 0 +Smad4 SMAD4 DNA-binding; Nuclear receptor co-regulator; Transcription, coactivator/corepressor P97471 17128 18 E2|18 49.51 cM mouse S342-p 15613801 GETFKVPsSCPVVTV MH2 protein stabilization; molecular association, regulation; enzymatic activity, induced apoptosis, induced; transcription, induced; signaling pathway regulation 29700281 2 0 0 increase MELK stability and activity; regulate ASK1/TGF-beta/p53 signaling pathways +CCAR1 CCAR1 Apoptosis; Nuclear receptor co-regulator; RNA splicing Q8IX12 55749 10q21.3 human Y192-p 460702 RVLVEATyNPNMPFK S1-like apoptosis, induced 16543231 1 1 0 +FOXA1 FOXA1 DNA-binding; Transcription factor P55317 3169 14q21.1 human K240-ac 11263050 RSPDKPGkGSYWTLH Forkhead molecular association, regulation chromatin organization, altered DNA(DISRUPTS) 19897491 1 0 0 +PYGO2 PYGO2 Cell development/differentiation; Histone-binding Q9BRQ0 90780 1q21.3 human S48-p 5965932 PEKKRRKsNTQGPAY protein stabilization 26170450 1 2 2 +IL6ST gp130 Membrane protein, integral; Receptor, cytokine P40189 3572 5q11.2 human Y814-p 450054 GILPRQQyFKQNCSQ cell cycle regulation; transcription, altered 10623831 3 0 1 +ATM ATM DNA repair, damage; EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, Ser/Thr (non-receptor); Protein kinase, atypical; Tumor suppressor Q13315 472 11q22.3 human T372-p 411189200 EISQSYTtTQRESSD enzymatic activity, inhibited; protein conformation cell cycle regulation; apoptosis, inhibited 27939942 1 0 0 +Nos1 nNOS Amino Acid Metabolism - arginine and proline; EC 1.14.13.39; Oxidoreductase P29476 24598 12q16 rat K739-ub 27201706 KKLAEAVkFSAKLMG protein degradation 23109339 1 2 0 +FOXO1 FOXO1A DNA-binding; Nuclear receptor co-regulator; Oncoprotein; Transcription factor Q12778 2308 13q14.11 human K274-ac 15625102 RSRAAKKkASLQSGQ intracellular localization; phosphorylation 20519497 4 0 0 +IQGAP1 IQGAP1 GAP; GAP, Ras; Motility/polarity/chemotaxis P46940 8826 15q26.1 human K1528-ub 12253471 GEQVDYYkSYIKTCL RasGAP_C molecular association, regulation CDC42(INDUCES); RAC1(INDUCES) 32094223 1 8 24 6KR mutant compared to WT +Mafb MAFB DNA-binding; Oncoprotein; Transcription factor; Tumor suppressor P54841 16658 2 H2|2 80.92 cM mouse K32-sm 12004404 DLLKFDVkKEPLGRA cell differentiation, inhibited; cell cycle regulation; cell growth, induced; transcription, inhibited 17548468 2 0 0 +PINK1 PINK1 EC 2.7.11.1; KINASE; Kinase, protein; Membrane protein, integral; Mitochondrial; Protein kinase, Other; Protein kinase, Ser/Thr (non-receptor) Q9BXM7 65018 1p36.12 human S402-p 25792201 GLQLPFSsWYVDRGG Pkinase ubiquitination; intracellular localization; protein conformation; phosphorylation; enzymatic activity, induced autophagy, induced 22910362; 23754282; 24189060; 25527497 5 1 0 PINK1 complex formation, Parkin recruitment onto depolarized mitochondria; mitophagy; T313A and S402A mutants interfere with PINK1 phosphorylation; regulate substrate phosphorylation, Parkin and Ubiquitin; promotes mitochondrial localization of parkin; Parkin recruitment; induce Ubiquitin-oxyester formation +Pparg PPAR-gamma DNA-binding; Nuclear receptor; Transcription factor P37238 19016 6 E3|6 53.41 cM mouse K293-ac 25780501 GEDKIKFkHITPLQE protein degradation; acetylation; molecular association, regulation N-CoR1(INDUCES); PRDM1(INDUCES) 22863012; 36394167 4 1 0 Impairs adipose plasticity During metabolic adaptions, mediates the diurnal cycle of adipose metabolism by destabilizing BMAL, rhythmicity in glucose tolerance and insulin sensitivity +ROCK1 ROCK1 EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, AGC; Protein kinase, Ser/Thr (non-receptor) Q13464 6093 18q11.1 human S1333-p 4935818 RASPRTLsTRSTANQ intracellular localization; enzymatic activity, induced cytoskeletal reorganization 21685893; 24168723 2 3 10 inhibits apical constriction +RAD17 RAD17 Cell cycle regulation O75943 5884 5q13.2 human T681-p 1868913302 EDYESDGt_______ molecular association, regulation; phosphorylation RAD1(INDUCES) 31353086 1 0 0 induces phosphorylation of other sites +DNMT1 DNMT1 Amino Acid Metabolism - cysteine and methionine; Cell development/differentiation; EC 2.1.1.37; METHYLTRANSFERASE; Methyltransferase; Methyltransferase, DNA; Transcription regulation P26358 1786 19p13.2 human K1054-ac 25171008 EEAVVDFkAVQGRCT BAH cell cycle regulation 21947282 1 1 0 +Hdac2 HDAC2 DEACETYLASE; Deacetylase; EC 3.5.1.98; Nuclear receptor co-regulator; Transcription, coactivator/corepressor P70288 15182 10 19.44 cM|10 B1 mouse S422-p 467979 IACDEEFsDSEDEGE enzymatic activity, induced 21576649 3 77 49 +IRS1 IRS1 Adaptor/scaffold; Motility/polarity/chemotaxis P35568 3667 2q36.3 human S1223-p 456047 SSSTRRSsEDLSAYA activity, inhibited SHP-2(DISRUPTS) 16020478 3 17 0 +GSTA4 GSTA4 EC 2.5.1.18; Other Amino Acids Metabolism - glutathione; Transferase; Xenobiotic Metabolism - drug metabolism - cytochrome P450; Xenobiotic Metabolism - metabolism by cytochrome P450 O15217 2941 6p12.2 human S189-p 455666 QEYTVKLsNIPTIKR GST_C_3 molecular association, regulation; intracellular localization HSP70(INDUCES) 12646569 1 0 0 +Mapk14 P38A EC 2.7.11.24; KINASE; Kinase, protein; Protein kinase, CMGC; Protein kinase, Ser/Thr (non-receptor) P47811 26416 17 A3.3|17 14.85 cM mouse T180-p 447970 RHTDDEMtGYVATRW Pkinase molecular association, regulation; phosphorylation; enzymatic activity, induced cell cycle regulation; carcinogenesis, inhibited; cell growth, inhibited; apoptosis, induced; cell motility, inhibited; transcription, induced; signaling pathway regulation; transcription, altered; cell growth, induced PKCZ(INDUCES) 10867029; 12032135; 15665819; 15975986; 16648139; 18669639; 19324872; 21847090; 25098293; 26517532; 34560245; 35112724; 35637461; 36310322; 36642184 401 73 1542 +Mapt Tau ACETYLTRANSFERASE; Acetyltransferase; Cytoskeletal P19332 29477 10q32.1 rat S510-p 447927 GERSGYSsPGSPGTP molecular association, regulation; protein conformation neural plasticity PPP1CC(INDUCES) 33519375; 36859689 91 33 33 +KCND1 KCND1 Membrane protein, integral; Membrane protein, multi-pass Q9NSA2 3750 Xp11.23 human S555-p 4714921 TASVSRGsMQELDML intracellular localization neural plasticity 34234278 1 4 0 +SNAI2 Snail2 Apoptosis; C2H2-type zinc finger protein; Motility/polarity/chemotaxis; Transcription factor O43623 6591 8q11.21 human S254-p 63243402 SKTFSRMsLLHKHEE zf-C2H2 activity, induced; protein stabilization; ubiquitination; intracellular localization carcinogenesis, induced; transcription, inhibited 29849120 3 0 0 induces transcriptional repressor activity, inhibits ubiquitination +PTPN18 BDP1 EC 3.1.3.48; Motility/polarity/chemotaxis; PHOSPHATASE; Protein phosphatase, tyrosine (non-receptor) Q99952 26469 2q21.1 human Y389-p 449000 SAEEAPLySKVTPRA molecular association, regulation TEC(INDUCES); SH2D1B(NOT_REPORTED); Arg(NOT_REPORTED) 14679216; 23322602 1 28 655 +Cebpb C/EBP-beta DNA-binding; Motility/polarity/chemotaxis; Transcription factor P21272 24253 3q42 rat K39-ac 473550 DCLAYGAkAARAAPR molecular association, regulation transcription, induced DNA(INDUCES) 24344329 4 0 0 +STAT3 STAT3 DNA-binding; Motility/polarity/chemotaxis; Nuclear receptor co-regulator; Transcription factor P40763 6774 17q21.2 human R688-me 1883327701 EAFGKYCrPESQEHP carcinogenesis, induced; cell motility, induced; transcription, induced 36151091 1 1 0 osteosarcoma cell migration, invasion and metastasis +SRC Src EC 2.7.10.2; KINASE; Kinase, protein; Oncoprotein; Protein kinase, TK; Protein kinase, tyrosine (non-receptor) P00523 396442 chicken S17-p 448231 DPSQRRRsLEPPDST phosphorylation cell growth, altered 2474754; 2582236 10 46 12 +TTK TTK Cancer Testis Antigen (CTA); EC 2.7.12.1; KINASE; Kinase, protein; Protein kinase, Other; Protein kinase, dual-specificity (non-receptor) P33981 7272 6q14.1 human T594-p 41389700 RLYDYEItDQYIYMV Pkinase intracellular localization; enzymatic activity, induced 26119734 1 0 0 regulates spindle assembly checkpoint and recruitment of SAC proteins +DCLRE1C Artemis DNA repair, damage; Deoxyribonuclease; EC 3.1.-.- Q96SD1 64421 10p13 human S649-p 38410201 NADSQSSsDFEVPST molecular association, regulation; intracellular localization DNA repair, induced PAXIP1(INDUCES) 25512557 1 1 0 Artemis prevents end resection and promotes non-homologous end joining +NR3C1 GR DNA-binding; Mitochondrial; Nuclear receptor; Transcription factor P04150 2908 5q31.3 human T562-p 1872513501 STWRIMTtLNMLGGR Hormone_recep molecular association, regulation 14-3-3 zeta(INDUCES) 33744286 1 1 0 +Cacna1c CACNA1C Channel, calcium; Membrane protein, integral; Membrane protein, multi-pass P22002 24239 4q42 rat S1699-p 4714250 PEIRRAIsGDLTAEE CAC1F_C intracellular localization 29180451 17 7 0 membrane expression and distribution of CACNA1C along the dendrites of hippocampal neurons; differentially regulates the surface traffic of CACNA1C +CHEK2 Chk2 EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, CAMK; Protein kinase, Ser/Thr (non-receptor); Tumor suppressor O96017 11200 22q12.1 human S28-p 447548 PHGSVTQsQGSSSQS phosphorylation; enzymatic activity, induced 12024051 3 0 0 +GYS1 GYS1 Carbohydrate Metabolism - starch and sucrose; EC 2.4.1.11; Transferase P13807 2997 19q13.33 human S641-p 448237 YRYPRPAsVPPSPSL Glycogen_syn enzymatic activity, inhibited; activity, inhibited signaling pathway regulation 19339242; 21668450; 22510711; 29541418 38 28 2 regulation of glycogen synthesis via R3F-PP1 signaling in astrocytoma cells +PIK3R1 PIK3R1 KINASE; Kinase, lipid; Motility/polarity/chemotaxis P23727 282307 cow S608-p 448133 ENTEDQYsLVEDDED enzymatic activity, inhibited 8313897 3 3 24 phosphorylation causes a decrease in PI3K activity. +Grin2b NMDAR2B Channel, calcium; Channel, ligand-gated; Membrane protein, integral; Membrane protein, multi-pass Q01097 14812 6 G1|6 66.38 cM mouse Y1472-p 448167 GSSNGHVyEKLSSIE NMDAR2_C activity, induced; receptor desensitization, altered; receptor internalization, altered; intracellular localization; phosphorylation neural plasticity; cell adhesion, induced; signaling pathway regulation 16190898; 16710293; 20427654; 26279570; 30916039; 33975959; 34433031; 34679709; 35536885 42 1 104 +ARAF ARAF EC 2.7.11.1; KINASE; Kinase, protein; Oncoprotein; Protein kinase, Ser/Thr (non-receptor); Protein kinase, TKL P10398 369 Xp11.3 human T452-p 3306308 IGDFGLAtVKTRWSG PK_Tyr_Ser-Thr enzymatic activity, induced 18662992 0 1 0 +TAB2 TAB2 Adaptor/scaffold Q9NYJ8 23118 6q25.1 human S419-p 456006 NSGASAAsRNMSGQV molecular association, regulation; intracellular localization ER-alpha(INDUCES) 12150997; 27992601 2 0 0 +TNFAIP3 TNFAIP3 Apoptosis; DEUBIQUITINASE; EC 3.4.19.12; Protease; UBIQUITIN LIGASE; Ubiquitin conjugating system; Ubiquitin ligase P21580 7128 6q23.3 human S480-p 31859341 TTAMKCRsPGCPFTL zf-A20 ubiquitination 26649818 1 2 0 cleavage of K63-linked tetraubiquitin ( all 4 sites or S381 alone), enhances ZnF4-mediated substrate ubiquitination +Nup210 NUP210 Membrane protein, integral; Nucleoporin P11654 58958 4q34 rat S1880-p 482838 SPPSGLWsPAYASH_ molecular association, regulation; intracellular localization 17559836 2 13 1 regulation of binding and recruitment of NUP210 to nuclear pore complex; Mitotic phosphorylation dissociates NUP210 from the NPC. +Cd274 PD-L1 Membrane protein, integral Q9EP73 60533 19|19 C1 mouse K262-ac 1875250200 TVLLFLRkQVRMLDV intracellular localization transcription, inhibited KPNA1(DISRUPTS); HIP1R(DISRUPTS) 32839551 1 1 0 nuclear localization that governs immune-response gene expression +OCLN occludin Cell adhesion; Membrane protein, integral; Membrane protein, multi-pass; Motility/polarity/chemotaxis Q16625 100506658 5q13.2 human T438-p 19083405 LYKRNFDtGLQEYKS Occludin_ELL intracellular localization 21545357 1 0 0 facilitates assembly of occludin into tight junction +DGCR8 DGCR8 Nucleolus; RNA processing; RNA-binding Q8WYQ5 54487 22q11.21 human S109-p 3208074 APAVRKFsPDLKLLK protein stabilization 24239349 0 16 0 +THOC5 FMIP Cell development/differentiation; RNA splicing; Spliceosome Q13769 8563 22q12.2 human Y225-p 25802102 EIEVKKEyLSSLQPR FmiP_Thoc5 molecular association, regulation; intracellular localization translation, altered; cell motility, altered; signaling pathway regulation RNA(INDUCES) 23032722; 26919114 2 1 0 cytosolic localization, chemokinesis +Il21r IL21R Membrane protein, integral; Receptor, cytokine Q9JHX3 60504 7|7 F3 mouse Y319-p 1270906 SALHLSLyPAKEKKF cell growth, altered 17234735 1 0 0 +MYOM2 myomesin 2 Contractile; Cytoskeletal P54296 9172 8p23.3 human S76-p 466426 RVCAKRVsTQEDEEQ molecular association, regulation cytoskeletal reorganization MYH1(INDUCES) 9529381 1 5 1 binding of myomesin 2 adjacent to the amino-terminal domain Mp1, to myosin rod (MYH1) +SLA SLAP Adaptor/scaffold Q13239 6503 8q24.22 human Y273-p 467049 SFFSSPPyFED____ activity, inhibited 24284075 1 2 5 oncogenic c-Kit bypasses the normal cellular negative feedback control +LRRK2 LRRK2 EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, Ser/Thr (non-receptor); Protein kinase, TKL Q5S007 120892 12q12 human S973-p 4725913 SHMRHSDsISSLASE protein stabilization; ubiquitination; enzymatic activity, inhibited; phosphorylation 25009464; 34144124 14 13 0 induces dephosphorylation at autophosphorylation sites; inhibits ubiquitination +ANXA1 ANXA1 Calcium-binding; Lipid-binding P04083 301 9q21.13 human Y21-p 447974 IENEEQEyVQTVKSS intracellular localization 16052208 5 16 171 EGF-stimulated increase in inward vesiculation is abolished in ANXA1 knockout cells, and rescued by WT but not by Y21F mutant ANXA1. +Crtc2 TORC2 Transcription, coactivator/corepressor Q3U182 74343 3|3 F1 mouse K628-ac 486389 DSSPGFSkEIAAALA TORC_C activity, induced; protein degradation; molecular association, regulation; ubiquitination transcription, induced p300(INDUCES) 18849969 1 0 0 +AMPH amphiphysin Vesicle P49418 273 7p14.1 human S654-p 1877626500 DVVLVVPsDSEADQD SH3_9 neural plasticity; apoptosis, inhibited 35858575 1 1 0 +POLH POLH DNA repair, damage; EC 2.7.7.7; Transferase Q9Y253 5429 6p21.1 human K475-sm 1877365907 PAVTATKkATTSLES intracellular localization; enzymatic activity, inhibited 32350109 1 1 0 +Slc12a5 KCC2 Membrane protein, integral; Membrane protein, multi-pass; Transporter; Transporter, SLC family Q63633 171373 3q42 rat Y1110-p 3087801 NRNGDENyMEFLEVL SLC12 activity, induced; protein degradation; molecular association, regulation; intracellular localization KCC2(INDUCES) 19679663; 20600929 3 0 0 decreases the cell surface stability of SLC12A5 (aka KCC2) +PPP2CA PPP2CA EC 3.1.3.16; Motility/polarity/chemotaxis; PHOSPHATASE; Protein phosphatase, Ser/Thr (non-receptor) P67775 5515 5q31.1 human Y127-p 4251175 SRQITQVyGFYDECL Metallophos phosphorylation 35820485 1 1 0 induces ERK and Tau phosphorylation +OPRM1 MOR-1 GPCR, family 1; Membrane protein, integral; Membrane protein, multi-pass; Receptor, GPCR P35372 4988 6q25.2 human S268-p 447782 LKSVRMLsGSKEKDR 7tm_1 receptor desensitization, altered 10908300 3 0 2 +EGR1 EGR1 C2H2-type zinc finger protein; DNA-binding; Transcription factor P18146 1958 5q31.2 human S26-p 458492 PFGSFPHsPTMDNYP cell motility, induced; cell growth, induced; apoptosis, inhibited; transcription, induced 34476983; 35041980 3 2 7 +TNC TNC Motility/polarity/chemotaxis; Secreted; Secreted, signal peptide P24821 3371 9q33.1 human K942-ub 1877447400 HAEVDVPkSQQATTK fn3 protein degradation autophagy, induced 32732922 1 1 0 defective autophagy is key immunosuppressive factor in TNBC tumours +Mpl MPL Membrane protein, integral; Receptor, cytokine Q08351 17480 4 D2.1|4 54.61 cM mouse S566-p 3091406 LEILPKSsESTPLPL activity, induced; phosphorylation cell growth, altered 10918061 1 0 0 tyrosine phosphorylation of JAK2 +HIPK2 HIPK2 EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, CMGC; Protein kinase, Ser/Thr (non-receptor) Q9H2X6 28996 7q34 human K1191-sm 2407407 GYPLSPAkVNQYPYI intracellular localization 10535925 1 0 0 localization to the nuclear speckles (dots) +SRSF1 SF2 RNA splicing; RNA-binding; Spliceosome Q07955 6426 17q22 human S209-p 2303911 YGRSRSRsRSRSRSR protein conformation 24449914 2 0 0 RS domain adopts an extended conformation +Dhx33 DHX33 EC 3.6.4.13; Helicase; Nucleolus Q80VY9 216877 11|11 B4 mouse T482-p 1883375203 KDDQLTLtPIGRKMA protein degradation 36403931 1 0 0 +Cd200r1 CD200R Membrane protein, integral; Receptor, misc. Q9ES57 57781 16|16 B4 mouse Y297-p 458379 TEKSNPLyDTVTKVE molecular association, regulation DOK2(INDUCES); DOK1(INDUCES) 16330532 2 2 11 +POLH POLH DNA repair, damage; EC 2.7.7.7; Transferase Q9Y253 5429 6p21.1 human K131-sm 1877365908 AVQERLQkLQGQPIS IMS intracellular localization; enzymatic activity, inhibited 32350109 1 1 0 +UPF1 RENT1 C2H2-type zinc finger protein; EC 3.6.1.-; EC 3.6.4.-; Hydrolase; RNA-binding Q92900 5976 19p13.11 human T28-p 21560213 AELLGADtQGSEFEF molecular association, regulation RNA stability, inhibited EST1A(INDUCES) 21965535 3 0 0 important for NMD (nonsense-mediated mRNA decay) +MYL2 MRLC2V Contractile P10916 4633 12q24.11 human S15-p 2846506 KRAGGANsNVFSMFE cell cycle regulation; carcinogenesis, induced; cell growth, induced 25412762 7 7 15 regulates cytokinesis +PTK2 FAK EC 2.7.10.2; KINASE; Kinase, protein; Protein kinase, TK; Protein kinase, tyrosine (non-receptor) Q00944 396416 chicken S726-p 1320900 GYPSPRSsEGFYPSP phosphorylation 15975092 1 0 1 primes for the GSK3-beta phosphorylation of S722 +HNF4A HNF4 alpha DNA-binding; Nuclear receptor; Transcription factor P41235 3172 20q13.12 human K458-ac 25336501 GAVATIVkPLSAIPQ protein degradation transcription, inhibited 21708125; 33636024 2 2 0 +ERBB4 HER4 EC 2.7.10.1; KINASE; Kinase, protein; Membrane protein, integral; Protein kinase, TK; Protein kinase, tyrosine (receptor) Q15303 2066 2q34 human Y1208-p 4825109 EYVNEPLyLNTFANT molecular association, regulation GRB2(INDUCES) 16729043 1 1 1 +CTNNB1 CTNNB1 Actin-binding; Cell adhesion; Motility/polarity/chemotaxis; Nuclear receptor co-regulator; Oncoprotein; Transcription factor P35222 1499 3p22.1 human K354-ac 27581500 LSVCSSNkPAIVEAG Arm molecular association, regulation; intracellular localization transcription, induced LEF-1(INDUCES) 23273980 2 0 0 +Stat3 STAT3 DNA-binding; Motility/polarity/chemotaxis; Nuclear receptor co-regulator; Transcription factor P52631 25125 10q31 rat Y705-p 448192 DPGSAAPyLKTKFIC activity, induced; protein stabilization; molecular association, regulation; intracellular localization cell differentiation, altered; apoptosis, altered; cell growth, induced; transcription, induced; signaling pathway regulation; transcription, altered SRC-1(INDUCES); CBP(INDUCES) 11922392; 12595539; 15860735; 16048438; 18230613; 19109898; 19427337; 33628191; 33781742 541 75 3065 induces YAP1 stabilization, induces S1PR2/STAT3/miR-135b/?-transduction repeat-containing protein/YAP/Notch3 pathway; induces neuroinflammation +SAFB2 SAFB2 Nuclear receptor co-regulator; RNA-binding Q14151 9667 19p13.3 human K225-m1 58123005 DILGETCkSEPVKEE molecular association, regulation L3MBTL iso4(INDUCES) 23583077 0 1 0 +Hcn4 HCN4 Channel, cation; Membrane protein, integral; Membrane protein, multi-pass O70507 330953 9|9 B mouse S1140-p 4699517 TLPRKTSsGSLPPPL activity, induced 20713547 1 0 0 required for PKA to shift the voltage dependence of HCN4 +Gja4 GJA4 Cell adhesion; Membrane protein, integral; Membrane protein, multi-pass P28235 14612 4 D2.2|4 61.47 cM mouse S319-p 3243300 APQGGRKsPSRPNSS molecular association, regulation; protein conformation cell cycle regulation; cell growth, inhibited GJA4(INDUCES) 32350069 2 2 0 regulation of intramolecular interaction +PREX1 PREX1 GEF; GEF, Rac/Rho Q8TCU6 57580 20q13.13 human S313-p 18704701 RVTGSKKsTKRTKSI activity, induced; activity, inhibited 21042280; 27788493 2 0 0 dephosphorylation of serines 313 and 319 negatively regulate GEF activity +Gpm6a GPM6A Cell surface; Channel, calcium; Membrane protein, integral; Membrane protein, multi-pass Q812E9 306439 16p11 rat S267-p 456834 QELHDIHsTRSKERL activity, induced 12359212 1 8 1 +Jund JunD Motility/polarity/chemotaxis; Transcription factor P15066 16478 8 B3.3|8 34.15 cM mouse S100-p 456168 LGLLKLAsPELERLI Jun transcription, altered 14676207 5 63 12 +Trpv4 TRPV4 Channel, cation; Membrane protein, integral; Membrane protein, multi-pass Q9EPK8 63873 5|5 F mouse Y253-p 448752 IERRCKHyVELLVAQ Ank activity, induced 12538589 1 0 0 +STX4 STX4 Membrane protein, integral; Vesicle Q12846 6810 16p11.2 human S78-p 1172732400 ATPLPEEsMKQELQN Syntaxin protein degradation; ubiquitination 29896202 1 0 0 induce resistance of tumor cells to Cisplatin +PAX8 PAX8 Transcription factor Q06710 7849 2q14.1 human K275-ub 1877752104 NSTLDDGkATLTPSN protein degradation; ubiquitination 31391550 1 0 0 +TRAPPC6A TRAPPC6A O75865 79090 19q13.32 human Y112-p 40253302 PMASGLQyLEEAPKF TRAPP intracellular localization; protein conformation apoptosis, induced 25650666; 27551439 2 0 0 Mutant proteins do not cause aggregation or caspase activation. ; protein aggregation, Ser35 phosphorylation is essential for relocation of TPC6A to the nucleolus and pTyr112 needed for relocation to the cytoplasm +H2ac1 H2A.4 DNA-binding Q8CGP4 319163 13|13 A3.1 mouse K119-ub 10836014 QAVLLPKkTESHKSQ Histone_H2A_C transcription, inhibited 34608337 1 2 130 PRC1 mediated repression is achieved by controlling transcriptional burst frequency +AKT1 Akt1 EC 2.7.11.1; KINASE; Kinase, protein; Oncoprotein; Protein kinase, AGC; Protein kinase, Ser/Thr (non-receptor) P31749 207 14q32.33 human S473-p 447855 RPHFPQFsYSASGTA Pkinase_C protein degradation; molecular association, regulation; enzymatic activity, inhibited; phosphorylation; enzymatic activity, induced; activity, induced; sumoylation; ubiquitination; intracellular localization; protein conformation cell cycle regulation; carcinogenesis, induced; apoptosis, altered; apoptosis, induced; cell motility, induced; cell motility, inhibited; signaling pathway regulation; cell differentiation, altered; cell growth, induced; cell motility, altered; autophagy, altered; DNA repair, inhibited; translation, induced; transcription, inhibited; cell growth, altered; cell differentiation, inhibited; carcinogenesis, inhibited; carcinogenesis, altered; cell growth, inhibited; transcription, induced; transcription, altered; autophagy, induced; cell differentiation, induced; apoptosis, inhibited; autophagy, inhibited; cytoskeletal reorganization; translation, inhibited NPM1(INDUCES); Sin1(INDUCES); PDK1(INDUCES); PAK1(INDUCES); PPP2CA(INDUCES); ILK(INDUCES); RICTOR(INDUCES); TGFBR3(INDUCES); TRAF6(INDUCES); PIK3R1(INDUCES) 10377409; 10400692; 10827191; 10926925; 10958682; 10973320; 11319202; 11358816; 11375271; 11389054; 11402048; 11577096; 11809760; 11978735; 12101233; 12149249; 12556562; 12642872; 12649200; 12686550; 12917346; 12970779; 14623889; 14713298; 14990993; 15028555; 15065872; 15327518; 15504738; 15546863; 15755769; 15781651; 15782140; 15808505; 16043647; 16044149; 16926151; 17386267; 17545609; 17586693; 18042541; 18209096; 18339839; 18678787; 18718903; 18931307; 18931661; 18957207; 19036927; 19574224; 19609947; 19797085; 19996208; 20008839; 20042122; 20085797; 20153512; 20228268; 20371716; 21057531; 21159648; 21177249; 21308747; 21329883; 21454539; 21530327; 21602434; 21743495; 21750219; 21775285; 21795477; 21908613; 21908616; 21980390; 22071574; 22080480; 22139837; 22580611; 23142783; 23188060; 23376850; 23644655; 23901139; 24297901; 24396487; 24446434; 24469056; 24632852; 24634221; 24670654; 25071014; 25100728; 25361894; 25745998; 25867063; 26411369; 26536663; 27197158; 28462918; 28676490; 29088759; 30413706; 31182807; 31679687; 31933886; 31978707; 32005974; 32081857; 32085396; 32101748; 32188912; 33407730; 33477794; 33574930; 33579227; 33592378; 33661942; 33664452; 33723214; 33727226; 33730574; 33741342; 33744230; 33753495; 33755959; 33767437; 33793628; 33835469; 33836561; 33845796; 33874915; 33890983; 33927349; 33941854; 33958720; 33984593; 33995548; 34021259; 34065746; 34073781; 34077419; 34078530; 34087103; 34132782; 34194551; 34208786; 34226680; 34237099; 34301793; 34326276; 34348155; 34380633; 34381564; 34383763; 34385295; 34385319; 34405859; 34418433; 34437633; 34465724; 34503444; 34523696; 34551282; 34588619; 34611309; 34639123; 34642304; 34675073; 34675258; 34686341; 34762647; 34780466; 34785213; 34785642; 34909046; 34921839; 34938598; 34948236; 34966427; 34973338; 34982576; 34995286; 35061720; 35070988; 35090553; 35126712; 35190555; 35201262; 35214753; 35250564; 35279705; 35347116; 35366279; 35367211; 35413055; 35545051; 35564180; 35577075; 35670054; 35773668; 35810308; 35835217; 35841593; 35864174; 35884549; 35907820; 35918763; 35962191; 35998013; 36053753; 36079767; 36139911; 36149602; 36174454; 36216931; 36269753; 36314765; 36348350; 36357572; 36413544; 36418288; 36471885; 36480552; 36509141; 36520954; 36525420; 36635496; 36640312; 36646789; 36652560; 36715448; 36724120; 36787291; 36822326; 37056386; 37078777; 37083591; 37324940; 37363966; 37430297; 37507012; 8978681; 9445477; 9690513 1956 25 44 +Lat2 LAB Adaptor/scaffold; Membrane protein, integral Q9JHL0 56743 5|5 G2 mouse Y98-p 455006 EGPESPRyQNFYKGS LAT2 signaling pathway regulation 22308309 2 2 4 plays a negative role in TCR and FcRI-mediated and no role in LPS-mediated signaling +SNRNP70 snRNP 70 RNA splicing; RNA-binding; Spliceosome P08621 6625 19q13.33 human S226-p 451900 YDERPGPsPLPHRDR molecular association, regulation; intracellular localization; protein conformation RNA splicing, induced SF2(INDUCES); snRNP A(INDUCES); snRNP B1(INDUCES); snRNP C(INDUCES); SMN(INDUCES) 33811140 2 87 8 +Map3k12 DLK EC 2.7.11.25; KINASE; Kinase, protein; Protein kinase, Ser/Thr (non-receptor); Protein kinase, TKL Q60700 26404 15|15 F3 mouse T659-p 40416400 GARGRGAtGGARDPG enzymatic activity, inhibited cell growth, induced 25802931 1 0 0 S584A T659A mutants have inhibited growth and increased kinase activity +USP24 USP24 DEUBIQUITINASE; EC 3.4.19.12; Protease; Ubiquitin-specific protease Q9UPU5 23358 1p32.3 human S2604-p 3216276 HLQQGSEsPMMIGEL protein degradation cell cycle regulation 27991932 1 23 1 +ARRB1 ARRB1 Adaptor/scaffold P49407 408 11q13.4 human S412-p 447493 EEEDGTGsPQLNNR_ activity, induced; molecular association, regulation; intracellular localization; activity, inhibited ADRB2(DISRUPTS); MEKK1(INDUCES) 10347142; 15456867; 19014372; 19153083 8 46 1 +SCN5A SCN5A Channel, sodium; Membrane protein, integral; Membrane protein, multi-pass Q14524 6331 3p22.2 human S1985-p 235474402 DSVTRATsDNLQVRG activity, induced; molecular association, regulation FGF13(DISRUPTS); Calmodulin(DISRUPTS) 28882890 2 2 0 impairs FGF13-dependent regulation of NaV1.5 channel inactivation +CLOCK CLOCK ACETYLTRANSFERASE; Acetyltransferase; DNA-binding; EC 2.3.1.48; Transcription factor O15516 9575 4q12 human T451-p 30259800 AVSDPSStPTKIPTD intracellular localization transcription, induced 24235147 1 1 0 regulate nuclear/cytoplasmic localization, Cdk5-mediated increased CLOCK transcription +PHLPP1 PHLPP EC 3.1.3.16; PHOSPHATASE; Protein phosphatase, Ser/Thr (non-receptor); Tumor suppressor O60346 23239 18q21.33 human S321-p 31863286 RRASPAPsDSSPGEP cell cycle regulation 33397691 1 2 0 +HSPA5 GRP78 Chaperone; Heat shock protein; KINASE P11021 3309 9q33.3 human K125-ac 13362601 KVVEKKTkPYIQVDI HSP70 molecular association, regulation; phosphorylation apoptosis, induced; signaling pathway regulation PERK(DISRUPTS) 20371724 1 2 0 induces phosphorylation of elf2a and activation of eIf2a-ATF4-CHOP pathway +PLN PLB Inhibitor; Membrane protein, integral P61012 414755 dog S16-p 448114 RSAIRRAsTIEMPQQ Phospholamban molecular association, regulation SERCA2(DISRUPTS) 17548345 78 15 66 +SND1 SND1 RNA-binding; Transcription, coactivator/corepressor Q7KZF4 27044 7q32.1 human T429-p 3203811 IRPASPAtETVPAFS SNase cell cycle regulation; transcription, induced 25627688 1 1 0 gene transcriptional activation of cyclin A and E2F-1 +AHCYL1 AHCYL1 Amino Acid Metabolism - cysteine and methionine; EC 3.3.1.1; Hydrolase; Other Amino Acids Metabolism - selenoamino acid O43865 10768 1p13.3 human S68-p 467244 RSLSRSIsQSSTDSY molecular association, regulation NHERF(INDUCES); NHE3(INDUCES) 27279487 6 1 1 +DGCR8 DGCR8 Nucleolus; RNA processing; RNA-binding Q8WYQ5 54487 22q11.21 human T371-p 18909948 REQSSDLtPSGDVSP protein stabilization 24239349 1 7 4 +BRAF BRAF EC 2.7.11.1; KINASE; Kinase, protein; Oncoprotein; Protein kinase, Ser/Thr (non-receptor); Protein kinase, TKL P15056 673 7q34 human S602-p 447805 FGLATVKsRWSGSHQ PK_Tyr_Ser-Thr molecular association, regulation; protein conformation; enzymatic activity, induced carcinogenesis, induced; cell differentiation, altered; cell growth, induced; transcription, induced; transcription, altered; cell growth, altered BRAF(NOT_REPORTED) 11032810; 11293329; 15710605; 18451171; 23907581; 26657898 11 0 0 phosphorylation at T599 and S602 and K578 ubiquitination mediate ERK activation +HEXIM1 HEXIM1 Motility/polarity/chemotaxis; Transcription factor O94992 10614 17q21.31 human K284-ub 9805702 ESLQNMSkQELIKEY HEXIM transcription, inhibited 19617712 1 1 0 +DNM1L DRP1 Apoptosis; EC 3.6.5.5; Endoplasmic reticulum; Hydrolase; Microtubule-binding; Mitochondrial; Motor O00429 10059 12p11.21 human S44-p 31866197 GKSSVLEsLVGRDLL Dynamin_N intracellular localization; phosphorylation; enzymatic activity, induced apoptosis, induced 25192600 2 1 0 mitochondrial localization, increased GTPase activity, mitochondrial fragmentation ; S44 serves as a priming site for S40 phosphorylation +Oprl1 KOR-3 GPCR, family 1; Membrane protein, integral; Membrane protein, multi-pass; Receptor, GPCR P35370 29256 3q43 rat S335-p 456133 RKFCCASsLHREMQV activity, induced; receptor desensitization, altered 16019191 1 0 0 +VCP VCP Chaperone; DNA repair, damage; EC 3.6.4.6; Endoplasmic reticulum; Hydrolase P55072 7415 9p13.3 human T761-p 3653838 KYEMFAQtLQQSRGF Vps4_C enzymatic activity, induced 19335618 1 2 0 +Cacng2 Stargazin Channel, calcium; Membrane protein, integral; Membrane protein, multi-pass O88602 12300 15 E1|15 36.92 cM mouse S243-p 455318 RSRSSSRsTEPSHSR activity, induced; intracellular localization 15664178; 20670832 3 0 0 AMPAR immobilization in synaptic membrane; enhances AMPA receptor responses and is required for long-term potentiation +Ryr2 RYR2 Channel, ligand-gated; Membrane protein, integral; Membrane protein, multi-pass; Transporter; Transporter, ion channel E9Q401 20191 13 A1|13 4.38 cM mouse G1885-p 2535900 GEEEAKGgKRPKEGL activity, induced 18326664 1 0 0 nearly abolished Ca2+ release activity in G1885E/G1886S mutant +VCP VCP Chaperone; DNA repair, damage; EC 3.6.4.6; Endoplasmic reticulum; Hydrolase P55072 7415 9p13.3 human K696-ac 7435507 EICQRACkLAIRESI AAA_lid_3 enzymatic activity, induced 19335618 1 1 4 +NPHP1 NPHP1 Cell adhesion O15259 4867 2q13 human Y46-p 18449508 PNKRQHIyQRCIQLK molecular association, regulation; intracellular localization PACS-1(INDUCES) 21357692 1 0 0 +IRS2 IRS2 Adaptor/scaffold; Motility/polarity/chemotaxis Q9Y4H2 8660 13q34 human S365-p 483509 SCRVRTAsEGDGGAA activity, inhibited 34731634 1 30 37 +PTPN1 PTP1B EC 3.1.3.48; Motility/polarity/chemotaxis; PHOSPHATASE; Phosphatase; Protein phosphatase, tyrosine (non-receptor) P18031 5770 20q13.13 human Y46-p 3791168 KNKNRNRyRDVSPFD Y_phosphatase molecular association, regulation; enzymatic activity, altered; phosphorylation INSR(DISRUPTS) 21487008; 31177093 2 0 66 +CGAS cGAS EC 2.7.7.86 Q8N884 115004 6q13 human K231-sm 59117703 NEFDVMFkLEVPRIQ Mab-21 protein stabilization 27637147 1 0 0 +Nfe2l2 NRF2 DNA-binding; Transcription factor Q60795 18024 2 C3|2 44.75 cM mouse S342-p 18258503 SGISLNTsPSRASPE protein degradation; molecular association, regulation BTRC(INDUCES) 21245377 3 1 0 +CDKN1B p27Kip1 Cell cycle regulation; Inhibitor; Oncoprotein; Protein kinase, regulatory subunit P46527 1027 12p13.1 human K165-ub 5018203 DDSSTQNkRANRTEE protein degradation; ubiquitination cell cycle regulation; cell growth, induced 10318797; 19056892; 31451788 3 0 0 degrade Cdkn1b for optimal ?-selection associated proliferation +H4c2 H4 DNA-binding P62806 326620 13|13 A3.1 mouse K20-m1 1458623 GGAKRHRkVLRDNIQ CENP-T_C cell cycle regulation; chromatin organization, altered; transcription, induced 19434510; 23428873; 23468428; 28746875 30 15 7 +MCU MCU Membrane protein, integral; Membrane protein, multi-pass; Mitochondrial Q8NE86 90550 10q22.1 human S92-p 27259017 VISVRLPsRRERCQF molecular association, regulation; protein conformation MCU(DISRUPTS) 26341627; 32499574 4 0 0 MCU-mediated mitochondrial Ca2+uptake, S92A mutant has a conformational change in L2-L4 loops which impairs Ca2+uptake.; inhibits dimerization; Regulates MCU activity +Ntrk2 TrkB EC 2.7.10.1; KINASE; Kinase, protein; Membrane protein, integral; Protein kinase, TK; Protein kinase, tyrosine (receptor) Q63604 25054 17p14 rat Y706-p 448812 DVYSTDYyRVGGHTM PK_Tyr_Ser-Thr molecular association, regulation; enzymatic activity, induced translation, altered; transcription, altered PLCG1(INDUCES); SHC1(INDUCES) 10533983; 16223723; 9582017 13 0 28 +EGLN1 EGLN1 EC 1.14.11.29; Oxidoreductase Q9GZT9 54583 1q42.2 human S61-p 56668114 HKLVCQGsEGALGHG enzymatic activity, inhibited signaling pathway regulation 35538889 1 2 0 regulates PHD2/HIFa/hepcidin/ferroportin signalling +Nr1h3 LXR-alpha DNA-binding; Motility/polarity/chemotaxis; Nuclear receptor Q9Z0Y9 22259 2 E1|2 50.52 cM mouse S291-p 479434 QIALLKTsAIEVMLL Hormone_recep molecular association, regulation; activity, inhibited transcription, inhibited; signaling pathway regulation SRC-1(DISRUPTS); N-CoR1(INDUCES); RXRA(DISRUPTS) 17296605 1 0 0 DNA Binding Activity of LXR/ RXR heterodimer was decreased. +TERF2 TRF2 DNA repair, damage; DNA-binding Q15554 7014 16q22.1 human R69-me 10338219 SRSSGRArRGRHEPG cell cycle regulation; cell growth, altered 19596784 1 0 0 +SMARCA4 SMARCA4 Cell cycle regulation; EC 3.6.1.-; EC 3.6.4.-; Helicase; Nuclear receptor co-regulator; Transcription, coactivator/corepressor; Tumor suppressor P51532 6597 19p13.2 human S1452-p 3191581 RPPAEKLsPNPPNLT ubiquitination carcinogenesis, induced; chromatin organization, altered; cell motility, induced; cell growth, induced 34237461 2 58 6 induces protein ubiquitination +Foxo1 FOXO1A DNA-binding; Nuclear receptor co-regulator; Oncoprotein; Transcription factor Q9R1E0 56458 3 C|3 23.19 cM mouse S429-p 478370 TYGQSSMsPLPQMPM FOXO_KIX_bdg molecular association, regulation transcription, inhibited DUSP6(INDUCES) 22848439 2 3 0 +CDKN2A p16-INK4A Cell cycle regulation; Nucleolus; Tumor suppressor P42771 1029 9p21.3 human S152-p 448832 IDAAEGPsDIPD___ protein stabilization; molecular association, regulation CDK4(INDUCES) 21270107 3 1 0 +PSME3 PSME3 Nuclear receptor co-regulator; Protease; Proteasome complex P61289 10197 17q21.31 human K195-ac 11318346 KLVSKIAkYPHVEDY PA28_beta molecular association, regulation; protein conformation; enzymatic activity, induced cell cycle regulation; cell growth, induced PSME3(INDUCES) 23612972 1 2 0 PSME3 heptamerization +RBM8A RBM8A RNA splicing; RNA-binding; Spliceosome; Translation Q9Y5S9 9939 1q21.1 human S168-p 456535 GGRRRSRsPDRRRR_ molecular association, regulation RNA splicing, altered UPF3B(DISRUPTS); NCBP1(DISRUPTS); THOC4(DISRUPTS); TAP(DISRUPTS); RPL22(DISRUPTS) 16100109 3 9 3 Phosphorylation is required for release downstream factors. Phosphorylation interferes with RBM8A's arginine methylation in vitro (by rat PRMT1) and in vivo. +AKT1S1 PRAS40 Apoptosis Q96B36 84335 19q13.33 human S183-p 482839 PTQQYAKsLPVSVPV PRAS molecular association, regulation mTOR(INDUCES); Raptor(DISRUPTS) 17517883; 21914810 5 66 25 +MCOLN1 mucolipin 1 Channel, cation; Membrane protein, integral; Membrane protein, multi-pass; Transporter, ion channel Q9GZU1 57192 19p13.2 human S559-p 1233700 KFRRGSGsACSLLCC activity, inhibited 17988215 1 3 0 +ITSN1 ITSN1 Adaptor/scaffold; Calcium-binding; GEF; GEF, Rac/Rho Q15811 6453 21q22.11 human T839-p 11125309 TPAPLAVtSSEPSTT INTAP molecular association, regulation; intracellular localization SYN1(INDUCES) 29078407 1 0 1 presynaptic nanoscale distribution of synapsin I +Fxyd1 PLM Cell surface; Channel, misc.; Membrane protein, integral O08589 58971 1q21 rat T89-p 455220 SSIRRLStRRR____ activity, induced; intracellular localization 19339511; 22535957 8 1 49 translocation to the cell surface +ZNF804B ZNF804B C2H2-type zinc finger protein A4D1E1 219578 7q21.13 human K163-ub 52490408 GRKVSCMkSALLLKG protein degradation 26676607 0 1 0 +Sh2b1 SH2-B-beta Adaptor/scaffold Q62985 89817 1q36 rat S165-p 21336501 VGRSVRGsVRGILQW intracellular localization cell motility, induced 23444381 2 0 0 disrupt localization at the plasma membrane.; macrophage migration +Adcy2 ADCY2 Adenylyl cyclase; EC 4.6.1.1; Lyase; Membrane protein, integral; Membrane protein, multi-pass; Nucleotide Metabolism - purine; Transporter; Transporter, aquaporin family P26769 81636 1p11 rat S490-p 25795203 DGAKMRAsVRMTRYL activity, induced 22906005 1 0 0 cAMP release +BANP BANP Tumor suppressor Q8N9N5 54971 16q24.2 human T337-p 41301700 VKSFSRRtPNSSSYC intracellular localization 26080397 1 0 0 cytoplasmic localization +IRS1 IRS1 Adaptor/scaffold; Motility/polarity/chemotaxis P35568 3667 2q36.3 human S307-p 450190 TRRSRTEsITATSPA molecular association, regulation; intracellular localization; phosphorylation INSR(DISRUPTS) 15143153; 16129690; 16914728; 34253290 56 12 1 disassociation of IRS2 from plasma membrane to cytosol; via cell fractionation experiments; limits PM-associated PI3K and PIP3 synthesis +H3C1 H3 DNA-binding P68431 8350 6p22.2 human S10-p 455676 TKQTARKsTGGKAPR Histone activity, induced; molecular association, regulation; acetylation; intracellular localization; methylation cell cycle regulation; carcinogenesis, induced; apoptosis, induced; transcription, induced; transcription, altered; cell growth, induced; chromatin organization, altered; apoptosis, inhibited; cytoskeletal reorganization; cell growth, altered H2AFV(INDUCES); 14-3-3 zeta(INDUCES); 14-3-3 epsilon(INDUCES); MYST1(INDUCES); H2AZ(INDUCES); BRD4(NOT_REPORTED); HP1 alpha(DISRUPTS) DNA(INDUCES) 10949293; 11784863; 12039950; 12234980; 12588998; 16222244; 16223729; 16354694; 16651411; 16687578; 17409387; 17643117; 17646159; 17891183; 17938195; 18234970; 18418070; 18418385; 18835819; 19766566; 19995936; 20003410; 21389100; 21820363; 21900495; 21900751; 22281053; 24876101; 25535969; 25553095; 25958199; 26607113; 27002159; 27162363; 27582276; 30115982; 30573684; 30626720; 33574676; 34570813; 34737366 241 15 1 +CDC25B CDC25B EC 3.1.3.48; Motility/polarity/chemotaxis; Nuclear receptor co-regulator; PHOSPHATASE; Protein phosphatase, dual-specificity P30305 994 20p13 human S323-p 448409 QRLFRSPsMPCSVIR M-inducer_phosp molecular association, regulation cell cycle regulation 14-3-3 beta(INDUCES); 14-3-3 epsilon(INDUCES) 11333986; 15629715 13 9 30 +Zap70 ZAP70 EC 2.7.10.2; KINASE; Kinase, protein; Protein kinase, TK; Protein kinase, tyrosine (non-receptor) P43404 22637 1 B|1 15.41 cM mouse Y318-p 447587 TSVYESPySDPEELK protein degradation; ubiquitination; protein conformation; phosphorylation signaling pathway regulation 21829558; 34452999; 35860252 58 7 263 regulates TCR signaling +Fancm FANCM EC 3.6.4.13; Helicase Q8BGE5 104806 12 C1|12 27.21 cM mouse S1025-p 28117600 ASHSAGNsQQNLESN molecular association, regulation MCM2(INDUCES) 31067464 2 1 0 +TBL1XR1 TBL1XR1 Nuclear receptor co-regulator; Transcription, coactivator/corepressor Q9BZK7 79718 3q26.32 human S123-p 2509601 AAASQQGsAKNGENT protein degradation transcription, induced 18374649 1 2 0 +SNCA SNCA Adaptor/scaffold P37840 6622 4q22.1 human K12-ub 466354 MKGLSKAkEGVVAAA Synuclein ubiquitination; phosphorylation 16847063 1 2 0 SNCA is phosphorylated, truncated, and then deposited to Lewy bodies.and then ubiquitinated which occurs at K12, K21. and K23 +ACLY ACLY Carbohydrate Metabolism - citrate (TCA) cycle; EC 2.3.3.8; Lyase; Transferase P53396 47 17q21.2 human K540-ac 31068004 FTGDHKQkFYWGHKE CoA_binding protein stabilization; molecular association, regulation; ubiquitination carcinogenesis, induced; cell growth, induced UBR4(INDUCES) 23932781; 31197036 2 1 7 inhibits ubiquitination, high glucose decreases interaction +ST13 HIP Adaptor/scaffold; Chaperone P50502 6767 22q13.2 human S346-p 21006300 AQNPANMsKYQSNPK STI1 receptor internalization, induced exocytosis, induced 21728385 1 1 0 required for agonist-induced internalization of CXCR4 +Adcy8 ADCY8 Adenylyl cyclase; EC 4.6.1.1; Lyase; Membrane protein, integral; Membrane protein, multi-pass; Nucleotide Metabolism - purine; Transporter; Transporter, aquaporin family P97490 11514 15 D1|15 29.03 cM mouse S113-p 26392110 VFPERSGsGSASGSG activity, inhibited 22976297 1 0 0 +Prkce PKCE EC 2.7.11.13; KINASE; Kinase, protein; Protein kinase, AGC; Protein kinase, Ser/Thr (non-receptor) P16054 18754 17|17 E4 mouse S346-p 2807904 SEDDRSKsAPTSPCD cell cycle regulation 18604201 3 11 0 +CRTC1 TORC1 iso2 Transcription factor Q6UUV9-2 23373 19p13.11 human S188-p 481987 PESFSSGsQDVHQKR TORC_M protein degradation transcription, inhibited 29408765 1 3 2 +MDC1 MDC1 Cell cycle regulation Q14676 9656 6p21.33 human T455-p 453677 TTERDSDtDVEEEEL molecular association, regulation cell cycle regulation NBS1(INDUCES) 18678890 1 37 95 MDC1-NBS1 interaction regulates intra-S-phase checkpoint activation +Flot2 FLOT2 Cell adhesion Q9Z2S9 83764 10q25 rat Y24-p 1270903 GGCCGSDyKQYVFGG Band_7 cell motility, altered; cytoskeletal reorganization 17213334 1 0 0 +NOX5 NOX5 iso4 EC 1.6.3.-; Membrane protein, integral; Membrane protein, multi-pass; Oxidoreductase Q96PH1-4 79400 15q23 human T494-p 472625 KRLSRSVtMRKSQRS FAD_binding_8 activity, induced; enzymatic activity, induced 17164239; 24505490; 24992705 5 0 0 +NPM1 NPM1 Nucleolus; Oncoprotein; RNA-binding; Translation P06748 4869 5q35.1 human K230-sm 1189202 KGQESFKkQEKTPKT molecular association, regulation apoptosis, inhibited; transcription, induced Rb(INDUCES) 17535915 3 0 0 promotes cell survival.; wild-type B23 slightly diminished DNA degradation +CEBPB C/EBP-beta DNA-binding; Motility/polarity/chemotaxis; Transcription factor P17676 1051 20q13.13 human K174-sm 6140810 PPPPAELkAEPGFEP molecular association, regulation transcription, inhibited HDAC4(INDUCES) 12810706; 18820298 3 2 0 +SPAST spastin Cytoskeletal; EC 3.6.4.3; Membrane protein, integral Q9UBP0 6683 2p22.3 human T306-p 3214842 NKPSTPTtATRKKKD intracellular localization cytoskeletal reorganization 32979422 2 3 7 involved in microtubule severing +TERT TERT iso3 DNA-binding; EC 2.7.7.49; Nucleolus; Transferase O14746-3 7015 5p15.33 human K78-ub 14561002 FRQVSCLkELVARVL protein degradation chromatin organization, altered; apoptosis, induced 20453884 1 0 0 +NR1H4 NR1H4 iso2 DNA-binding; Nuclear receptor Q96RI1-2 9971 12q23.1 human K122-sm 31089518 GASAGRIkGDELCVV molecular association, regulation transcription, inhibited DNA(DISRUPTS) 23546875 1 0 0 +H3c1 H3 DNA-binding P68433 360198 13|13 A3.1 mouse K36-ac 466364 APATGGVkKPHRYRP Histone molecular association, regulation; intracellular localization transcription, induced DNA(INDUCES) 17189264; 20561915 8 7 6 +Grm5 mGluR5 GPCR, family 3; Membrane protein, integral; Membrane protein, multi-pass; Receptor, GPCR P31424 24418 1q32 rat S1158-p 25581600 LVALTPPsPFRDSVD GluR_Homer-bdg neural plasticity 24769228 4 0 0 +Tnni3 TNNI3 Actin-binding; Motility/polarity/chemotaxis; Motor P23693 29248 1q12 rat S43-p 450690 AKKKSKIsASRKLQL cell motility, altered 16936010 24 2 0 heart contractility and relaxation +Hand1 HAND1 Cell development/differentiation; DNA-binding; Nucleolus; Transcription factor Q64279 15110 11 B1.3|11 35.27 cM mouse S109-p 12518702 KERRRTEsINSAFAE HLH intracellular localization; protein conformation cell differentiation, altered 17891141 1 0 0 release from nucleolus, dimerization +MIIP MIIP Motility/polarity/chemotaxis Q5JXC2 60672 1p36.22 human S303-p 4170074 YHIHRRKsFDASDTL MIIP molecular association, regulation cell motility, induced; transcription, induced NFkB-p65(INDUCES) 29038521 1 22 2 tumor metastasis +ITGB4 ITGB4 iso2 Cell adhesion; Membrane protein, integral; Motility/polarity/chemotaxis; Receptor, misc. P16144-2 3691 17q25.1 human T1727-p 480544 GSLTRHVtQEFVSRT molecular association, regulation; protein conformation Plectin-1(DISRUPTS); ITGB4 iso2(INDUCES) 22357621 1 4 15 regulates HD assembly +RB1 Rb Nuclear receptor co-regulator; Oncoprotein; Transcription, coactivator/corepressor; Tumor suppressor P06400 5925 13q14.2 human T826-p 447984 LPTPTKMtPRSRILV Rb_C molecular association, regulation cell cycle regulation; cell growth, induced; transcription, induced; cell growth, altered Elf-1(DISRUPTS); E2F1(DISRUPTS); Rb(INDUCES); TFDP1(DISRUPTS) DNA(DISRUPTS) 16360038; 34158578; 36047562; 8626527; 9315635 20 37 56 +RAPGEF1 RAPGEF1 GEF; GEF, Ras; Motility/polarity/chemotaxis Q13905 2889 9q34.13 human Y504-p 448393 APIPSVPyAPFAAIL activity, induced; intracellular localization; enzymatic activity, induced; phosphorylation cell cycle regulation; apoptosis, altered; cell growth, induced; cell differentiation, induced; signaling pathway regulation; transcription, altered 10318861; 12734187; 15320955; 18957052; 20581864; 21876762; 24396067; 28790195; 30567575; 32296045 12 0 0 regulates the ADP-P2Y12-PI3K-Rap1 pathway; neurite growth +GLS glutaminase Amino Acid Metabolism - alanine, aspartate and glutamate; Amino Acid Metabolism - arginine and proline; EC 3.5.1.2; Energy Metabolism - nitrogen; Hydrolase; Mitochondrial; Other Amino Acids Metabolism - D-Glutamine and D-glutamate O94925 2744 2q32.2 human K311-ac 7248642 YVHRYVGkEPSGLRF Glutaminase ubiquitination; enzymatic activity, inhibited; protein conformation carcinogenesis, inhibited; cell growth, inhibited; cell motility, inhibited glutaminase(INDUCES); TRIM21(INDUCES) 23935106; 35864951 2 4 1 interaction between TRIM21 and GAC led to K63-linked ubiquitination and inhibited GAC enzymatic activity; TEM micrographs, K311 acetylation induces inhibition of superoligomer assembly +SPRTN SPRTN DNA repair, damage Q9H040 83932 1q42.2 human K230-ac 1875273400 KGKAKLGkEPVLAAE intracellular localization 32649882 1 0 0 recruitment to chromatin, DNA-protein crosslinks (DPCs) repair +IRAK1 IRAK1 EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, Ser/Thr (non-receptor); Protein kinase, TKL P51617 3654 Xq28 human S131-p 4273531 PAEAEAWsPRKLPSS molecular association, regulation; enzymatic activity, induced transcription, induced PIN1(INDUCES) 21743479; 27790836 2 9 0 +Klf5 KLF5 C2H2-type zinc finger protein; DNA-binding; Transcription factor Q9Z0Z7 12224 14|14 E2.2 mouse K202-sm 4664700 EVNNIFIkQELPIPD intracellular localization carcinogenesis, induced; cell growth, induced 18782761 2 1 0 +Mef2c MEF2C DNA-binding; Transcription factor Q8CFN5 17260 13 C3|13 43.68 cM mouse T20-p 455602 DERNRQVtFTKRKFG SRF-TF apoptosis, inhibited; transcription, altered 15735306 1 0 0 +Ikzf1 Ikaros C2H2-type zinc finger protein; DNA-binding; Transcription factor Q03267 22778 11 A1|11 7.02 cM mouse S214-p 28735107 RSYKQRSsLEEHKER zf-C2H2 molecular association, regulation; intracellular localization transcription, induced DNA(INDUCES) 23977012 1 1 0 nuclear localization, ITGA4, MDM1, EIF4E3, KIF23, TNFAIP8L2 DNA binding/transcription inhibited by BTK siRNA +Prkab1 AMPKB1 Autophagy; KINASE; Protein kinase, regulatory subunit P80386 83803 12q16 rat S25-p 448112 KTPRRDSsGGTKDGD intracellular localization 11171104 3 1 4 +Ido1 INDO Amino Acid Metabolism - tryptophan; Cell cycle regulation; EC 1.13.11.52; Oxidoreductase P28776 15930 8|8 A2 mouse Y253-p 21393601 KLPEGLLyEGVWDTP IDO molecular association, regulation transcription, induced; signaling pathway regulation SHP-2(INDUCES); SHP-1(INDUCES) 21804557 1 0 0 Phosphorylation of INDO at Y115 and Y253 induced enzyme activity of SHP-1/SHP-2. +SLC4A1 SLC4A1 Membrane protein, integral; Membrane protein, multi-pass; Transporter; Transporter, SLC family P02730 6521 17q21.31 human Y359-p 455384 AKPDSSFyKGLDLNG activity, induced; molecular association, regulation; intracellular localization; phosphorylation SHP-2(INDUCES) 12070037; 15649129; 18827007; 32411010; 32517126 8 5 50 induces capacitation, AR and viability +MEF2D MEF2D DNA-binding; Transcription factor Q14814 4209 1q22 human S251-p 3196577 NKVIPAKsPPPPTHS intracellular localization; activity, inhibited transcription, inhibited 34109727 2 43 5 phosphorylation of this site inhibits MEF2D import into the nucleus +CERS2 LASS2 DNA-binding; Membrane protein, integral; Membrane protein, multi-pass; Transferase Q96G23 29956 1q21.3 human T346-p 469769 ERSDREEtESSEGEE enzymatic activity, induced 26887952 1 42 217 +Gata1 GATA1 DNA-binding; Transcription factor P17679 14460 X A1.1|X 3.59 cM mouse K137-sm 3819000 NTFLDTLkTERLSPD transcription, inhibited 15173587 4 0 0 inhibition of GATA-1 transcription is specific +AP4E1 AP4E1 Adaptor/scaffold Q9UPM8 23431 15q21.2 human S871-p 22598800 VEKFSYCsLSTPSLF receptor recycling, inhibited 21810154 1 0 0 +Anxa1 ANXA1 Calcium-binding; Lipid-binding P10107 16952 19 B|19 13.83 cM mouse S27-p 447972 EYVQAVKsYKGGPGS intracellular localization 16720734 8 0 0 +Foxp1 FOXP1 C2H2-type zinc finger protein; Cell cycle regulation; DNA-binding; Transcription factor P58462 108655 6|6 D3 mouse K664-sm 610814010 AVHPIHVkEEPLDPE molecular association, regulation cell differentiation, altered; cell motility, induced; cell growth, induced; cytoskeletal reorganization HDAC1(DISRUPTS); HDAC2(DISRUPTS); MTA2(DISRUPTS); MTA1(DISRUPTS) 29138280 2 1 0 +SPRY2 SPRY2 Adaptor/scaffold; Inhibitor; Motility/polarity/chemotaxis O43597 10253 13q31.1 human Y283-p 3978700 LKLCQGCyDRVNRPG Sprouty activity, inhibited; phosphorylation transcription, altered 15637081 1 0 0 +Ulk1 ULK1 Autophagy; EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, Other; Protein kinase, Ser/Thr (non-receptor) O70405 22241 5|5 F mouse S415-p 4958506 CSSSPSPsGRPGPFS molecular association, regulation; phosphorylation; enzymatic activity, induced carcinogenesis, induced; autophagy, induced LC3B(INDUCES); GABARAPL1(INDUCES) 33654220 1 1 2 induces phosphorylation of itself at the other site and of BECN1 and ATG13 +CEP131 CEP131 Calcium-binding Q9UPN4 22994 17q25.3 human S78-p 1211822 NNLRRSNsTTQVSQP molecular association, regulation cell cycle regulation; cytoskeletal reorganization 14-3-3 zeta(INDUCES); 14-3-3 epsilon(INDUCES) 26616734; 30804208 2 28 61 maintain integrity of centriolar satellites in interphase; 14-3-3-dependent centriolar satellite remodelling upon cell stress. +LRRK2 LRRK2 EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, Ser/Thr (non-receptor); Protein kinase, TKL Q5S007 120892 12q12 human T1343-p 10426319 KLMIVGNtGSGKTTL Roc molecular association, regulation; protein conformation TUBB(DISRUPTS) 21806997; 24275654 6 5 0 +Syn1 SYN1 Vesicle P09951 24949 Xq11 rat S9-p 448378 NYLRRRLsDSNFMAN Synapsin_N activity, induced; intracellular localization neural plasticity 14557263; 19896987; 23461423 25 5 2 +CREBBP CBP ACETYLTRANSFERASE; Acetyltransferase; DNA-binding; EC 2.3.1.48; Motility/polarity/chemotaxis; Nuclear receptor co-regulator; Transcription, coactivator/corepressor Q92793 1387 16p13.3 human T1871-p 474502 LMRRRMAtMNTRNVP molecular association, regulation; ubiquitination carcinogenesis, induced; cell growth, induced; signaling pathway regulation MDM2(INDUCES) 22349818; 23434580 3 0 0 +MDC1 MDC1 Cell cycle regulation Q14676 9656 6p21.33 human T4-p 3965656 ____MEDtQAIDWDV molecular association, regulation; intracellular localization cell cycle regulation; DNA repair, induced MDC1(INDUCES) 22234877; 28193847 2 3 1 maintenance of chrosome stabiliy +TTK TTK Cancer Testis Antigen (CTA); EC 2.7.12.1; KINASE; Kinase, protein; Protein kinase, Other; Protein kinase, dual-specificity (non-receptor) P33981 7272 6q14.1 human T371-p 1737600 LLAKLEEtKEYQEPE intracellular localization; enzymatic activity, induced cell cycle regulation 25265012; 26119734 2 2 1 regulates spindle assembly checkpoint and recruitment of SAC proteins; autophosphorylation of this site is required for release TTK from kinetochore; causes decreased kinetochore localization of BubR1 and Mad2. +MAP4 MAP4 Cytoskeletal; Motility/polarity/chemotaxis P27816 4134 3p21.31 human K838-ac 15292997 PKKPTAIkTEGKPAE cytoskeletal reorganization 28002468 1 2 4 +Cebpa C/EBP-alpha DNA-binding; Transcription factor P05554 24252 1q21 rat K298-ac 56394104 RNNIAVRkSRDKAKQ bZIP_2 molecular association, regulation autophagy, induced beclin 1(INDUCES) 34217716 2 0 0 +PTPN1 PTP1B EC 3.1.3.48; Motility/polarity/chemotaxis; PHOSPHATASE; Phosphatase; Protein phosphatase, tyrosine (non-receptor) P18031 5770 20q13.13 human Y66-p 447812 LHQEDNDyINASLIK Y_phosphatase molecular association, regulation; enzymatic activity, induced INSR(INDUCES) 8999839; 9355745 3 2 44 +Sod2 SOD2 EC 1.15.1.1; Mitochondrial; Oxidoreductase P09671 20656 17 A1|17 8.75 cM mouse K134-ac 27585069 SFEKFKEkLTAVSVG Sod_Fe_C protein conformation; enzymatic activity, altered 28433661 0 3 0 +Gsdmd GSDMD Lipid-binding Q9D8T2 69146 15|15 D3 mouse S46-p 1883583906 CLLNRKFsSSRFWKP Gasdermin molecular association, regulation; intracellular localization carcinogenesis, induced GSDMD(DISRUPTS) 37495617 1 0 0 +STAT6 STAT6 DNA-binding; Transcription factor P42226 6778 12q13.3 human Y641-p 447757 MGKDGRGyVPATIKM molecular association, regulation; intracellular localization carcinogenesis, induced; cell differentiation, induced; transcription, induced; signaling pathway regulation STAT6(INDUCES) DNA(INDUCES) 22000020; 32015091; 34521750 27 6 95 induce HSD3B1 transcription +WWC1 KIBRA Adaptor/scaffold Q8IX03 23286 5q34 human S548-p 30312500 SSPSPPCsPLMADPL cell growth, induced 24269383 1 0 0 +Tnni3 TNNI3 Actin-binding; Motility/polarity/chemotaxis; Motor P23693 29248 1q12 rat S23-p 448423 PAPVRRRsSANYRAY Troponin-I_N protein conformation; activity, inhibited cell motility, altered; cytoskeletal reorganization 16236710; 16936010; 18550549; 28587770 68 11 11 heart contractility and relaxation; regulates cardiac contractile function +FRS2 FRS2 Adaptor/scaffold Q8WU20 10818 12q15 human Y349-p 449784 RRTALLNyENLPSLP molecular association, regulation cell differentiation, induced SOS1(INDUCES); GRB2(INDUCES) 11278583 3 11 89 +PAK6 PAK6 EC 2.7.11.1; KINASE; Kinase, protein; Nuclear receptor co-regulator; Protein kinase, STE; Protein kinase, Ser/Thr (non-receptor) Q9NQU5 56924 15q15.1 human Y566-p 454426 KSLVGTPyWMAPEVI Pkinase enzymatic activity, induced 15550393 1 0 1 +CACNA1C CACNA1C Channel, calcium; Membrane protein, integral; Membrane protein, multi-pass Q13936 775 12p13.33 human Y2217-p 1043301 ELQDSRVyVSSL___ activity, induced; molecular association, regulation Src(INDUCES) 17942635 2 0 0 +IRF3 IRF3 DNA-binding; Transcription factor Q14653 3661 19q13.33 human S82-p 1878269104 TWKRNFRsALNRKEG molecular association, regulation; intracellular localization transcription, inhibited DNA(DISRUPTS) 35948267 1 1 0 +SCML2 SCML2 Transcription factor Q9UQR0 10389 Xp22.13 human S511-p 449227 VPYVVPLsPKLPKTK cell cycle regulation 24358021 2 34 21 +PKMYT1 Myt1 EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, Other; Protein kinase, Ser/Thr (non-receptor); Protein kinase, dual-specificity (non-receptor) Q99640 9088 16p13.3 human S416-p 11331004 PPATPPGsPPCSLLL molecular association, regulation PIN1(INDUCES) 10504341 1 0 0 +Rrad RRAD G protein; G protein, monomeric; G protein, monomeric, RGK O88667 56437 8|8 D3 mouse S26-p 4700219 ERDRRRGsTPWGPAP activity, induced; molecular association, regulation CACNA1C(DISRUPTS) 31969708 2 6 1 induces Cav1.2 currents +Ezr Ezrin Cytoskeletal; Motility/polarity/chemotaxis P26040 22350 17|17 A1 mouse Y478-p 454875 PPPPPPVyEPVNYHV carcinogenesis, induced; cell motility, induced; cell growth, induced 22397367 10 4 137 +Pld1 PLD1 iso2 EC 3.1.4.4; Lipid Metabolism - ether lipid; Lipid Metabolism - glycerophospholipid; Motility/polarity/chemotaxis; Phospholipase P70496-2 25096 2q24 rat S561-p 448574 SRKFSKFsLYRQLHR enzymatic activity, induced 10441128; 10788479 3 4 0 +GLI1 GLI1 C2H2-type zinc finger protein; Oncoprotein; Transcription factor P08151 2735 12q13.3 human K415-sm 1873076604 SISTVEPkREREGGP protein stabilization; ubiquitination; intracellular localization cell growth, induced; transcription, induced; signaling pathway regulation 28630282 1 0 0 inhibits ubiquitination, enhances Shh signaling +CLDN3 Claudin-3 Cytoskeletal; Membrane protein, integral; Membrane protein, multi-pass O15551 1365 7q11.23 human T192-p 455751 PPREKKYtATKVVYS intracellular localization; activity, inhibited cell adhesion, altered 15905176 1 0 0 cell adhesion = tight junctions +PARP1 PARP1 DNA repair, damage; EC 2.4.2.30; Nuclear envelope; Nuclear receptor co-regulator; Nucleolus; Transferase P09874 142 1q42.12 human K209-ub 21180922 VKSEGKRkGDEVDGV cell motility, induced; cell growth, induced; apoptosis, inhibited; DNA repair, inhibited; signaling pathway regulation 36088509 1 1 0 HECTD3 activates the EGFR-mediated signalling pathway through PARP1. +HIPK2 HIPK2 EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, CMGC; Protein kinase, Ser/Thr (non-receptor) Q9H2X6 28996 7q34 human T1114-p 28847906 APAALGStGTVAHLV protein stabilization; molecular association, regulation; phosphorylation; enzymatic activity, induced PPM1D(DISRUPTS) 23871434 1 0 0 increase protein stabilization and reduce phosphorylation of WIP1 +Ppargc1a PGC-1 alpha Nuclear receptor co-regulator; Transcription, coactivator/corepressor O70343 19017 5|5 C1 mouse S568-p 20612406 PQRMRSRsRSFSRHR protein stabilization; molecular association, regulation; activity, inhibited transcription, inhibited; signaling pathway regulation HNF4 alpha(DISRUPTS) 21646374; 23201126 2 0 0 Gluconeogenic pathway; Regulation of gluconeogenesis +Ascl1 ASCL1 DNA-binding; Transcription factor Q02067 17172 10|10 C1 mouse S150-p 453455 GAANKKMsKVETLRS HLH protein stabilization; molecular association, regulation transcription, inhibited E2A iso2(INDUCES) 15318167 1 0 0 +Rptor Raptor Adaptor/scaffold Q8K4Q0 74370 11|11 E2 mouse S792-p 2314600 DKMRRVSsYSALNSL molecular association, regulation; phosphorylation cell cycle regulation; transcription, altered; signaling pathway regulation; translation, inhibited 14-3-3 zeta(INDUCES); 14-3-3 gamma(INDUCES) 18439900; 26357899; 32912901 36 4 0 inhibits mTORC1 signaling; inhibits S6 and ULK1 phosphorylation through inhibiting mTORC1 signaling +SNAI1 Snail1 C2H2-type zinc finger protein; Transcription factor O95863 6615 20q13.13 human S119-p 6097706 SFSSTSVsSLEAEAY intracellular localization cell motility, altered; transcription, altered 15448698; 19004823 2 0 0 Localization mediated by S107, S111, S115 and S119. +GAB2 GAB2 Adaptor/scaffold Q9UQC2 9846 11q14.1 human S210-p 4825112 AENARSAsFSQGTRA molecular association, regulation; intracellular localization; activity, inhibited; phosphorylation cell growth, altered 14-3-3 beta(INDUCES); SHC1(DISRUPTS); GRB2(DISRUPTS); EGFR(DISRUPTS) 19172738 3 19 8 +SHC1 SHC1 iso2 Adaptor/scaffold; Apoptosis; Mitochondrial; Motility/polarity/chemotaxis P29353-2 6464 1q21.3 human Y240-p 448510 EPPDHQYyNDFPGKE activity, induced; molecular association, regulation; activity, inhibited; phosphorylation cell growth, induced; cell motility, altered; transcription, induced; cytoskeletal reorganization GRB2(INDUCES); SHIP(INDUCES); GRB2(DISRUPTS); ZAP70(INDUCES); VAV1(INDUCES) 10598576; 10891441; 17537990; 9121430; 9813159 29 22 943 Y317F activates MAPK; f-actin cytoskeleton, chemotaxis. +DDHD1 DDHD1 EC 3.1.1.-; Phospholipase Q8NEL9 80821 14q22.1 human S8-p 22351354 MNYPGRGsPRSPEHN phosphorylation 34089703 1 10 0 regulates phosphorylation at other sites +Opn4 melanopsin GPCR, family 1; Membrane protein, integral; Membrane protein, multi-pass; Receptor, GPCR Q9QXZ9 30044 14|14 B mouse S394-p 23257073 RSTLSSQsSDLSWIS molecular association, regulation; protein conformation ARRB1(INDUCES) 32236094 1 1 1 +PRL prolactin Cytokine; Motility/polarity/chemotaxis; Secreted; Secreted, signal peptide P01239 280901 cow S120-p 451505 LILGLLRsWNDPLYH Hormone_1 protein conformation; activity, inhibited 12850287 2 0 0 +CSK CSK EC 2.7.10.2; KINASE; Kinase, protein; Protein kinase, TK; Protein kinase, tyrosine (non-receptor) P41240 1445 15q24.1 human S364-p 448477 ALREKKFsTKSDVWS PK_Tyr_Ser-Thr phosphorylation; enzymatic activity, induced PKACA(INDUCES) 11181701; 12600271 5 0 0 In vitro the presence of SH3 domain of CSK greatly increases phosphotransferase activity of CSK. PKA mediated phosphorylation of S364 is independent of SH3 domain. +PDGFRB PDGFRB EC 2.7.10.1; KINASE; Kinase, protein; Membrane protein, integral; Oncoprotein; Protein kinase, TK; Protein kinase, tyrosine (receptor) P09619 5159 5q32 human Y686-p 7437801 IITEYCRyGDLVDYL PK_Tyr_Ser-Thr enzymatic activity, induced cell motility, altered 19275932 1 3 1 in vitro +CHKA CHKA EC 2.7.1.32; EC 2.7.1.82; Kinase, other; Lipid Metabolism - glycerophospholipid P35790 1119 11q13.2 human S279-p 1876872804 KKLHKLLsYNLPLEL Choline_kinase carcinogenesis, induced; cell growth, induced; apoptosis, inhibited 35463311 1 0 0 +PRKAA2 AMPKA2 Autophagy; EC 2.7.11.1; EC 2.7.11.27; EC 2.7.11.31; KINASE; Kinase, protein; Protein kinase, CAMK; Protein kinase, Ser/Thr (non-receptor) P54646 5563 1p32.2 human K379-ub 27177165 PLIADSPkARCPLDA enzymatic activity, inhibited 31996460 1 1 0 +Hdac5 HDAC5 DEACETYLASE; Deacetylase; EC 3.5.1.98; Hydrolase Q9Z2V6 15184 11|11 D mouse S488-p 447996 RPLSRTQsSPLPQSP molecular association, regulation 14-3-3 epsilon(INDUCES); MEF2C(DISRUPTS) 11114197 24 7 4 +SHC3 SHC3 iso2 Adaptor/scaffold; Motility/polarity/chemotaxis Q92529-2 53358 9q22.1 human Y218-p 451254 GDGSDHPyYNSIPSK molecular association, regulation CRK(INDUCES); RAPGEF1(INDUCES) 11791173 3 1 3 +SYK Syk EC 2.7.10.2; KINASE; Kinase, protein; Protein kinase, TK; Protein kinase, tyrosine (non-receptor) P43405 6850 9q22.2 human S297-p 1983707 ISRIKSYsFPKPGHR molecular association, regulation; ubiquitination; intracellular localization; phosphorylation signaling pathway regulation 14-3-3 gamma(INDUCES); ubiquitin(DISRUPTS); Ig-beta(DISRUPTS) 21469132 4 11 23 inhibits ubiquitination, inhibits phosphorylation of substrates and hence BCR signaling +Myl12b MRLC2 Contractile Q3THE2 67938 17|17 E1.3 mouse S20-p 448595 KRPQRATsNVFAMFD activity, induced; molecular association, regulation cell motility, induced; apoptosis, inhibited; cytoskeletal reorganization 11485996; 19062278; 34113824 62 64 295 +IRS1 IRS1 Adaptor/scaffold; Motility/polarity/chemotaxis P35568 3667 2q36.3 human S270-p 447566 EFRPRSKsQSSSNCS molecular association, regulation; intracellular localization 14-3-3 beta(INDUCES) 34253290; 9312143 6 15 31 +Gata4 GATA4 Motility/polarity/chemotaxis; Transcription factor Q08369 14463 14 D1|14 33.24 cM mouse K311-ac 18380901 PRPLAMRkEGIQTRK cell growth, induced; transcription, induced 20833366 2 0 0 +Kcnj5 GIRK4 Channel, potassium; Membrane protein, integral; Membrane protein, multi-pass P48548 29713 8q21 rat S191-p 450684 GCMFVKIsQPKKRAE IRK activity, inhibited 14732702 1 0 0 inhibition of channel open-state probability +XRCC5 Ku80 DNA-binding; EC 3.6.1.-; EC 3.6.4.-; Helicase; Nuclear receptor co-regulator; Nucleolus; RNA-binding P13010 7520 2q35 human K532-ub 10836853 KSQIPLSkIKTLFPL Ku_C molecular association, regulation DNA repair, induced DNA(DISRUPTS) 27895153 1 8 57 +FADD FADD Adaptor/scaffold; Apoptosis Q13158 8772 11q13.3 human K149-sm 62489902 RESLRIWkNTEKENA Death molecular association, regulation; intracellular localization CASP10(INDUCES); DRP1(INDUCES) 27799292 1 0 0 +SNAI1 Snail1 C2H2-type zinc finger protein; Transcription factor O95863 6615 20q13.13 human S249-p 1867725600 ARTFSRMsLLHKHQE protein degradation; molecular association, regulation; ubiquitination carcinogenesis, inhibited; signaling pathway regulation PAR3(INDUCES); BTRC(INDUCES) 30804505 1 0 0 +H3c1 H3 DNA-binding P68433 360198 13|13 A3.1 mouse T58-p 481137 IRRYQKStELLIRKL Histone molecular association, regulation chromatin organization, altered; transcription, inhibited DNA(DISRUPTS) 26199864 1 10 0 +Inpp5d SHIP EC 3.1.3.86; Motility/polarity/chemotaxis; Phosphatase, lipid Q9ES52 16331 1 D|1 44.44 cM mouse Y1021-p 448865 EMFENPLyGSVSSFP molecular association, regulation SHIP(INDUCES); SHC1(INDUCES); DOK1(INDUCES) 11031258; 22182704; 9099679 10 15 202 +STIM1 STIM1 Calcium-binding; Endoplasmic reticulum; Membrane protein, integral Q13586 6786 11p15.4 human S621-gl 1870757303 SRSHSPSsPDPDTPS molecular association, regulation; activity, inhibited; phosphorylation EB1(DISRUPTS); ORAI1(INDUCES) 33023909 1 0 0 phosphorylation of STIM1 at S621may increase SOCE activity +Cald1 Caldesmon Actin-binding Q62736 25687 4q22 rat S497-p 448465 KSPDGNKsPAPKPSD Caldesmon intracellular localization cytoskeletal reorganization 16289153 7 21 0 +CDC73 CDC73 Cell cycle regulation; Tumor suppressor Q6P1J9 79577 1q31.2 human Y293-p 20831311 IPAAYNRyDQERFKG CDC73_N molecular association, regulation; protein conformation transcription, inhibited; signaling pathway regulation CTNNB1(DISRUPTS) 21726809 1 0 0 inhibits Wnt signaling pathway +PKN1 PKN1 EC 2.7.11.13; KINASE; Kinase, protein; Protein kinase, AGC; Protein kinase, Ser/Thr (non-receptor) Q16512 5585 19p13.12 human S537-p 483282 GTFSPGAsPGSEART enzymatic activity, induced carcinogenesis, induced; cell motility, induced; cell growth, induced 31981797 1 33 2 induces anchorage-independent cell growth +Ndel1 NDEL1 Microtubule-binding; Protease Q9ERR1 83431 11|11 B3 mouse S242-p 3685801 IPNGFGTsPLTPSAR NUDE_C activity, induced; intracellular localization cell motility, altered 18331715 3 4 1 Cdc42 activation +SLC12A3 NCCT Membrane protein, integral; Membrane protein, multi-pass; Transporter; Transporter, SLC family P55017 6559 16q13 human T60-p 469617 MRTFGYNtIDVVPTY AA_permease_N activity, induced; molecular association, regulation; protein conformation ADD3(DISRUPTS) 18270262; 21164023; 36792826 25 3 0 +FANCD2 FANCD2 DNA repair, damage Q9BXW9 2177 3p25.3 human S319-p 34734267 LPSRLQAsQVKLKSK FancD2 activity, induced; molecular association, regulation; ubiquitination; intracellular localization signaling pathway regulation DNA(INDUCES) 37392383 1 3 12 regulates the FA pathway +CD19 CD19 Cell surface; Membrane protein, integral P15391 930 16p11.2 human Y378-p 463123 LGGTAPSyGNPSSDV activity, induced; molecular association, regulation SOS1(INDUCES); GRB2(INDUCES) 10706702 1 1 4 +Lcp1 L-plastin Actin-binding; Motility/polarity/chemotaxis Q61233 18826 14 D3|14 39.63 cM mouse S5-p 450852 ___MARGsVSDEEMM endocytosis, induced; cytoskeletal reorganization 30248139; 33858961 15 49 4 induces phagocytosis; sealing ring formation (nascent sealing zone) in osteoclasts, bone resorption +Hspb1 HSP27 Chaperone; Heat shock protein; Motility/polarity/chemotaxis; SUMO LIGASE; SUMO ligase P42930 24471 12q12 rat S15-p 448401 FSLLRSPsWEPFRDW intracellular localization 36260112 52 78 30 +MOK MOK EC 2.7.11.22; KINASE; Kinase, protein; Protein kinase, CMGC; Protein kinase, Ser/Thr (non-receptor) Q9UQ07 5891 14q32.31 human Y161-p 450006 SKQPYTEyISTRWYR Pkinase activity, induced 10421840 1 1 0 While the authors did not prove that these sites were phosphorylated, mutation of both T159 and Y161, located in the activation loop, abolished the enzymatic activity of the kinase. +PHLPP1 PHLPP EC 3.1.3.16; PHOSPHATASE; Protein phosphatase, Ser/Thr (non-receptor); Tumor suppressor O60346 23239 18q21.33 human T1363-p 22769303 HVQSVLLtPQDEFFI PP2C protein degradation 19797085 1 1 0 PHLPP phosphorylation induces degradation and Akt1 activation negatively regulates degradation. +Bcl2l11 BIM Apoptosis O54918 12125 2|2 F1 mouse Y161-p 810853200 GDEFNETyTRRVFAN Bclx_interact protein stabilization apoptosis, inhibited 29391601 1 0 0 +Npm1 NPM1 Nucleolus; Oncoprotein; RNA-binding; Translation Q61937 18148 11|11 A4 mouse S48-p 14577038 QLSLRTVsLGAGAKD Nucleoplasmin protein conformation 24616519 2 3 0 +NDC80 HEC1 Cell cycle regulation O14777 10403 18p11.32 human S55-p 459763 PTSERKVsLFGKRTS Ndc80_HEC cell cycle regulation; chromatin organization, altered; cytoskeletal reorganization 17129782; 33988677; 35638575; 35878017; 36897279 14 13 0 +STK3 MST2 Autophagy; EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, STE; Protein kinase, Ser/Thr (non-receptor) Q13188 6788 8q22.2 human S15-p 4272103 KSKLKKLsEDSLTKQ molecular association, regulation; ubiquitination; intracellular localization; enzymatic activity, inhibited; phosphorylation cell cycle regulation; carcinogenesis, induced NEK2(DISRUPTS) 21723128; 35780183; 37739411 3 16 0 TRIM69 regulates centrosome dynamics and mitotic progression and centrosome amplification, regulates centrosome clustering, promotes triple-negative breast cancer; TRIM69A regulates MST2 ubiquitination and intracellular localization +RRM1 RRM1 DNA replication; EC 1.17.4.1; Nucleotide Metabolism - purine; Nucleotide Metabolism - pyrimidine; Other Amino Acids Metabolism - glutathione; Oxidoreductase P23921 6240 11p15.4 human S631-p 41454201 IYTRRVLsGEFQIVN Ribonuc_red_lgC molecular association, regulation; enzymatic activity, induced carcinogenesis, induced; cell growth, induced; apoptosis, inhibited RRM2(INDUCES) 34126361 1 2 0 regulates RNR enzymatic activity for DNA replication +Rps6kb1 p70S6K EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, AGC; Protein kinase, Ser/Thr (non-receptor); Translation Q8BSK8 72508 11|11 C mouse K516-ac 14790001 QAFPMISkRPEHLRM cell growth, induced 27345368 4 1 0 +Crtc3 TORC3 Transcription, coactivator/corepressor Q91X84 70461 7|7 D3 mouse S162-p 7101661 SALNRTNsDSALHTS TORC_M molecular association, regulation transcription, inhibited 14-3-3 beta(INDUCES) 23033494 1 8 2 inhibits nuclear localization +Runx2 AML3 iso5 DNA-binding; Transcription factor Q08775-5 12393 17 B3|17 21.33 cM mouse T326-p 14694701 SPSIHSTtPLSSTRG activity, induced transcription, induced 20484411 1 0 0 +Irs1 IRS1 Adaptor/scaffold; Motility/polarity/chemotaxis P35569 16367 1 C5|1 42.0 cM mouse S731-p 2352500 TGDYMNMsPVGDSNT molecular association, regulation PIK3C2A(DISRUPTS) 10092613 2 0 0 +Drd1 DRD1 GPCR, family 1; Membrane protein, integral; Membrane protein, multi-pass; Receptor, GPCR Q61616 13488 13 B1|13 28.4 cM mouse S421-p 30310300 EKLSPALsVILDYDT intracellular localization signaling pathway regulation 25304015 2 0 0 membrane localization, regulates behavioral responses to cocaine in mice. +POLR2A POLR2A EC 2.7.7.48; EC 2.7.7.6; Nucleotide Metabolism - purine; Nucleotide Metabolism - pyrimidine; Transcription initiation complex; Transferase P24928 5430 17p13.1 human K1838-ac 1883802900 SYSPASPkYTPTSPS transcription, induced 35322029 1 0 0 RCOR1 represses transcription by deacetylation of K1838 +RANBP2 RANBP2 Adaptor/scaffold; EC 5.2.1.8; EC 6.3.2.-; Ligase; Nuclear export; Nucleoporin; SUMO LIGASE; SUMO conjugating system; SUMO ligase P49792 5903 2q13 human S2280-p 452315 SALSPSKsPAKLNQS molecular association, regulation; intracellular localization BICD2(INDUCES) 26051540 1 46 1 targets BicD2 to the NE of RGP cells to induce apical nuclear migration +Ahcyl2 AHCYL2 Amino Acid Metabolism - cysteine and methionine; EC 3.3.1.1; Hydrolase; Motility/polarity/chemotaxis; Other Amino Acids Metabolism - selenoamino acid Q68FL4 74340 6|6 A3.3 mouse S151-p 4734539 RSLSRSIsQSSTDSY molecular association, regulation SLC4A4(INDUCES) 27382360 2 0 1 S149 and T172 are also involved in activation of SLCA4 +Bach2 BACH2 DNA-binding; Transcription factor P97303 12014 4|4 A5 mouse S509-p 15407975 PIKVCPRsPPLETRT intracellular localization; activity, inhibited transcription, induced 26620562 1 5 7 increased repressor activity of Bach2 S509A and Bach2 S535A mutants was observed +FPR2 FPR2 GPCR, family 1; Membrane protein, integral; Membrane protein, multi-pass; Motility/polarity/chemotaxis; Receptor, GPCR P25090 2358 19q13.41 human S329-p 19075301 ERALSEDsAPTNDTA receptor desensitization, induced 21543323 1 0 0 +CDCA8 Borealin Cell cycle regulation; Nucleolus Q53HL2 55143 1p34.3 human T230-p 4203200 DSKEIFLtVPVGGGE Borealin molecular association, regulation; protein conformation; phosphorylation cell cycle regulation; cytoskeletal reorganization Borealin(INDUCES) 18243099; 19530738 2 0 0 stimulates phosphorylation of CENPA S7; important for chromosome alignment; chromosome alignment in mitosis +IQGAP1 IQGAP1 GAP; GAP, Ras; Motility/polarity/chemotaxis P46940 8826 15q26.1 human K1155-ub 12341105 AIVSSVDkIPYGMRF RasGAP molecular association, regulation CDC42(INDUCES); RAC1(INDUCES) 32094223 1 7 3 6KR mutant compared to WT; no effect of K1155R or K1230R mutants on CDC42 or Rac binding +FOXO3 FOXO3A Autophagy; DNA-binding; Oncoprotein; Transcription factor O43524 2309 6q21 human S413-p 12084437 GLMQRSSsFPYTTKG activity, induced; phosphorylation transcription, induced; signaling pathway regulation 17711846; 31679687 5 7 2 induces phosphorylation of other sites; in glucose starvation +ZNF148 ZNF148 C2H2-type zinc finger protein; DNA-binding; Transcription, coactivator/corepressor Q9UQR1 7707 3q21.2 human K356-sm 2798307 YSSSTKVkDEYMVAE transcription, inhibited 17940278 1 2 0 +PDGFRA PDGFRA EC 2.7.10.1; KINASE; Kinase, protein; Membrane protein, integral; Oncoprotein; Protein kinase, TK; Protein kinase, tyrosine (receptor) P16234 5156 4q12 human Y849-p 448441 DIMHDSNyVSKGSTF PK_Tyr_Ser-Thr phosphorylation; enzymatic activity, induced cell differentiation, inhibited; carcinogenesis, induced; cell motility, induced; cell growth, induced; signaling pathway regulation 33626330; 34858182; 35393545 8 9 59 regulates the phosphorylation of DUSP1/p38MAPK and inhibits cell differentiation through the DUSP1/p38MAPK pathway +Ywhag 14-3-3 gamma Adaptor/scaffold P61982 22628 5|5 G2 mouse S59-p 3892745 VVGARRSsWRVISSI 14-3-3 molecular association, regulation 14-3-3 gamma(INDUCES) 25086053 2 0 8 +ABL1 Abl EC 2.7.10.2; KINASE; Kinase, protein; Oncoprotein; Protein kinase, TK; Protein kinase, tyrosine (non-receptor) P00519 25 9q34.12 human Y226-p 450303 KRNKPTVyGVSPNYD enzymatic activity, induced cell cycle regulation; cell differentiation, altered; carcinogenesis, inhibited; cell growth, inhibited; cell motility, induced 20228840; 26473374; 35569509 28 12 304 +Tgfb1i1 Hic-5 Motility/polarity/chemotaxis; Nuclear receptor co-regulator; Transcription, coactivator/corepressor Q62219 21804 7|7 F3 mouse Y60-p 450964 TGDKDHLySTVCKPR cytoskeletal reorganization 16183059 3 7 20 phosphorylation of this site after EGF induction leads to reduction of Rac activity and formation of lamellipodia +CXCR2 IL8RB GPCR, family 1; Membrane protein, integral; Membrane protein, multi-pass; Receptor, GPCR; Receptor, cytokine P25025 3579 2q35 human S347-p 451046 LPKDSRPsFVGSSSG protein degradation; receptor desensitization, altered; receptor internalization, altered 9079638 1 2 5 +CEBPA C/EBP-alpha DNA-binding; Transcription factor P49715 1050 19q13.11 human K302-ac 56394105 AVRKSRDkAKQRNVE bZIP_2 molecular association, regulation cell differentiation, inhibited; transcription, inhibited DNA(DISRUPTS) 27005833 2 0 0 +Nrip1 RIP140 Nuclear receptor co-regulator; Transcription, coactivator/corepressor Q8CBD1 268903 16|16 C3.1 mouse T202-p 456686 KDQKSGPtLPDVTPN NRIP1_repr_1 activity, induced; molecular association, regulation; acetylation; intracellular localization cell differentiation, induced; transcription, inhibited p300(INDUCES) 16093479; 18655826 2 2 0 increases acetylation of RIP140 at K158 and K287 +Etv4 ETV4 DNA-binding P28322 18612 11 D|11 65.48 cM mouse K317-ac 26373306 DVCIVPEkFEGDIKQ ETS_PEA3_N sumoylation transcription, induced 21543453 1 1 0 acetylated sites inhibits sumoylation reciprocally +SLC5A6 SLC5A6 Membrane protein, integral; Membrane protein, multi-pass; Transporter; Transporter, SLC family Q9Y289 8884 2p23.3 human T286-p 20503442 QRYLSSRtEKAAVLS SSF activity, inhibited 21570947 1 0 0 biotin uptake inhibited +Cdk16 CDK16 Cell cycle regulation; EC 2.7.11.22; KINASE; Kinase, protein; Motility/polarity/chemotaxis; Protein kinase, CMGC; Protein kinase, Ser/Thr (non-receptor) Q04735 18555 X A1.3|X 16.18 cM mouse T175-p 7445726 LDKLGEGtYATVYKG Pkinase molecular association, regulation CCNYL1(INDUCES) 26305884 1 13 14 +ORC2 ORC2 DNA replication Q13416 4999 2q33.1 human T226-p 7320974 SAPVGKEtPSKRMKR molecular association, regulation cell cycle regulation DNA(DISRUPTS) 22334659; 24732362 3 23 17 +FCAR FCAR Immunoglobulin superfamily; Membrane protein, integral P24071 2204 19q13.42 human S284-p 1870031100 LTFARTPsVCK____ molecular association, regulation; intracellular localization; activity, inhibited Ig-alpha(DISRUPTS) 30766540 1 0 0 +AURKA AurA EC 2.7.11.1; KINASE; Kinase, protein; Oncoprotein; Protein kinase, Other; Protein kinase, Ser/Thr (non-receptor) O14965 6790 20q13.2 human S342-p 457608 QETYKRIsRVEFTFP Pkinase enzymatic activity, induced cell cycle regulation; cytoskeletal reorganization 16246726 3 2 0 +KDM5B JARID1B Cancer Testis Antigen (CTA); DEMETHYLASE; Demethylase; EC 1.14.11.-; Oxidoreductase; Transcription, coactivator/corepressor Q9UGL1 10765 1q32.1 human K242-ub 38557706 RAEAMNIkIEPEETT intracellular localization; enzymatic activity, induced carcinogenesis, inhibited 25596733 1 2 0 decreases H3K4Me3 methylation, induces senescence +Adcy6 ADCY6 Adenylyl cyclase; EC 4.6.1.1; Lyase; Membrane protein, integral; Membrane protein, multi-pass; Nucleotide Metabolism - purine; Transporter; Transporter, aquaporin family AAA40678 25289 7q36 rat S674-p 455529 EDLEKKYsRKVDPRF Adcy_cons_dom enzymatic activity, inhibited 11877398; 15470083 2 0 0 decreases potentiation +CDKN2A p16-INK4A Cell cycle regulation; Nucleolus; Tumor suppressor P42771 1029 9p21.3 human R138-me 62906109 RAAAGGTrGSNHARI Ank_2 cell growth, induced; apoptosis, inhibited 28120917 1 0 0 +BCL6 Bcl-6 C2H2-type zinc finger protein; Oncoprotein; Transcription factor P41182 604 3q27.3 human K379-ac 460604 ACNWKKYkFIVLNSL molecular association, regulation HDAC2(DISRUPTS) 12402037 1 0 0 +H4c2 H4 DNA-binding P62806 326620 13|13 A3.1 mouse K8-ac 458959 SGRGKGGkGLGKGGA protein degradation cell cycle regulation; chromatin organization, altered; apoptosis, induced; transcription, induced; transcription, altered 17344422; 17530637; 17626110; 17823087; 20543957; 33087562 85 21 529 +ERGIC3 SDBCAG84 Membrane protein, integral; Membrane protein, multi-pass; Motility/polarity/chemotaxis; Vesicle Q9Y282 51614 20q11.22 human K8-ub 12317401 MEALGKLkQFDAYPK ERGIC_N protein degradation 31142615 1 8 4 trafficking and secretion of alpha1-antitrypsin and haptoglobin +ERBB2 HER2 EC 2.7.10.1; KINASE; Kinase, protein; Membrane protein, integral; Oncoprotein; Protein kinase, TK; Protein kinase, tyrosine (receptor) P04626 2064 17q12 human T1172-p 451643 ATLERPKtLSPGKNG receptor desensitization, altered 8700533 1 0 2 +GLI3 GLI3 C2H2-type zinc finger protein; Transcription factor P10071 2737 7p14.1 human S849-p 7998355 NMLNRRDsSASTISS protein processing transcription, inhibited 10693759 1 1 6 +ARRB2 ARRB2 iso2 Adaptor/scaffold P32120-2 281638 cow K400-sm 25350102 RLRLKGLkDEDYDDQ molecular association, regulation AP-2 beta(INDUCES) 21118812 1 0 0 GPCR endocytosis induced +PCM1 PCM-1 Cell cycle regulation; Oncoprotein Q15154 5108 8p22 human S372-p 11536118 RRQAESLsLTREVSQ intracellular localization; protein conformation autophagy, altered 26755742; 28712572 2 11 12 +Trpv1 TRPV1 Channel, cation; Membrane protein, integral; Membrane protein, multi-pass; Receptor, misc. Q704Y3 193034 11 B4|11 45.25 cM mouse T145-p 456216 QKSKKRLtDSEFKDP Ank_2 receptor desensitization, altered 16954222 5 0 0 +RBL1 Rb-like 1 Transcription, coactivator/corepressor; Tumor suppressor P28749 5933 20q11.23 human S975-p 450986 HIKQQPGsPRRISQQ Rb_C cell growth, altered 11884610 2 0 1 +Nek1 NEK1 EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, Other; Protein kinase, Ser/Thr (non-receptor) P51954 18004 8 B3.1|8 30.91 cM mouse T141-p 65958203 IFLTKDGtVQLGDFG Pkinase enzymatic activity, induced cell cycle regulation; carcinogenesis, induced; DNA repair, induced; cell growth, induced; apoptosis, induced; transcription, induced 30928383 3 0 0 +Gli2 GLI2 C2H2-type zinc finger protein; Oncoprotein; Transcription factor Q0VGT2 14633 1 E2.3|1 52.17 cM mouse S848-p 25352005 TDASRRSsEASQCSG sumoylation 22549777 1 1 0 +GRB10 GRB10 Adaptor/scaffold Q13322 2887 7p12.1 human S476-p 455870 MNILGSQsPLHPSTL protein stabilization; activity, inhibited 15952796; 21659604 7 16 17 +RIOK1 RIOK1 EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, Ser/Thr (non-receptor); Protein kinase, atypical Q9BRS2 83732 6p24.3 human T410-p 797986500 MEIASQRtKEERSSQ protein stabilization 29384474 1 1 0 RIOK1 phosphorylation at T410 by CK2 blocks methylation at K411 by SETD7 and stabilizes RIOK1 +TRAIP TRAIP EC 6.3.2.-; Ligase; Nucleolus; UBIQUITIN LIGASE; Ubiquitin conjugating system; Ubiquitin ligase Q9BWF2 10293 3p21.31 human K80-sm 53529104 VLDAEFLkNELDNVR protein stabilization; ubiquitination; intracellular localization 26820530 2 0 0 inhibits ubiquitination +NCL NCL DNA-binding; Helicase; Nuclear receptor co-regulator; Nucleolus; RNA-binding P19338 4691 2q37.1 human S34-p 466005 DSEDEEMsEDEEDDS intracellular localization cell cycle regulation; cell growth, induced 25313645 3 42 9 +BAG2 BAG2 Apoptosis O95816 9532 6p12.1 human K186-ub 21129790 RNIENSDkAIKLLEH BAG protein degradation; molecular association, regulation apoptosis, induced LOXL1(DISRUPTS) 32424143 1 5 0 +NOS3 eNOS Amino Acid Metabolism - arginine and proline; EC 1.14.13.39; Oxidoreductase P29473 287024 cow T497-p 447885 AGITRKKtFKEVANA molecular association, regulation; enzymatic activity, inhibited Calmodulin(INDUCES) 11292821; 12869534; 12952971; 26987903; 34474112 82 2 1 +RELA NFkB-p65 DNA-binding; Nuclear receptor co-regulator; Transcription factor Q04206 5970 11q13.1 human S468-p 451145 AVFTDLAsVDNSEFQ activity, induced; protein degradation; molecular association, regulation; ubiquitination; intracellular localization; activity, inhibited carcinogenesis, induced; carcinogenesis, inhibited; cell growth, inhibited; apoptosis, induced; cell motility, induced; transcription, induced; transcription, altered; apoptosis, inhibited; transcription, inhibited COMMD1(INDUCES); CUL2(INDUCES) DNA(INDUCES) 15465828; 16046471; 16407239; 18201972; 19270718; 20188669; 20507904; 33459422; 34082140; 34674717; 35779404; 35890077; 35950917 22 0 0 +Oprd1 DOR-1 GPCR, family 1; Membrane protein, integral; Membrane protein, multi-pass; Receptor, GPCR P32300 18386 4 D2.3|4 64.78 cM mouse T161-p 455533 VKALDFRtPAKAKLI 7tm_1 receptor desensitization, altered 11861651 3 0 0 +YAP1 YAP1 Oncoprotein; Transcription, coactivator/corepressor P46937 10413 11q22.1 human S127-p 448847 PQHVRAHsSPASLQL activity, induced; protein degradation; molecular association, regulation; ubiquitination; intracellular localization; activity, inhibited; phosphorylation cell cycle regulation; carcinogenesis, induced; apoptosis, altered; cell motility, induced; apoptosis, induced; cell motility, inhibited; signaling pathway regulation; cell differentiation, altered; cell growth, induced; cell motility, altered; transcription, inhibited; cell growth, altered; cell differentiation, inhibited; carcinogenesis, altered; carcinogenesis, inhibited; cell growth, inhibited; transcription, induced; transcription, altered; autophagy, induced; cell differentiation, induced; apoptosis, inhibited; cytoskeletal reorganization; cell adhesion, altered 14-3-3 sigma(INDUCES); 14-3-3 zeta(INDUCES); 14-3-3 eta(INDUCES); p73(DISRUPTS); 14-3-3 beta(INDUCES); 53BP2(INDUCES); TEAD1(DISRUPTS); AML2(INDUCES); CTNNB1(INDUCES) DNA(DISRUPTS) 12535517; 18640976; 20153295; 20729916; 20823509; 21666719; 21730131; 21945154; 22234184; 24362629; 24658687; 24803537; 25360797; 25362852; 25373897; 25601544; 25605730; 25739674; 25772246; 26039999; 26265440; 26364602; 26549256; 26598551; 27425596; 28171658; 28273460; 28416665; 28474680; 28775168; 28793266; 31239271; 31988076; 32053631; 32064037; 32205868; 32271880; 32929029; 33162394; 33536280; 33545120; 33552953; 33622361; 33630828; 33990468; 34058200; 34129887; 34206989; 34462276; 34465890; 34482636; 34516278; 34593639; 34663879; 34743733; 34874746; 35000271; 35027733; 35065073; 35102250; 35172140; 35210364; 35307353; 35440025; 35452623; 35586495; 35713503; 35731019; 35761037; 35773411; 35780183; 35858343; 35882980; 36001958; 36015285; 36044856; 36115593; 36318920; 36346780; 36369000; 36588499; 36622276; 36640330; 36643034; 36747492; 36774339; 36823643; 37100374; 37319316 207 33 180 +Dnm2 DYN2 EC 3.6.5.5; Hydrolase; Microtubule-binding; Motility/polarity/chemotaxis; Vesicle P39054 13430 9 A3|9 7.79 cM mouse Y597-p 451200 NTEQRNVyKDLRQIE PH cytoskeletal reorganization 21411625 5 1 2 promotes focal adhesion turnover +SORT1 SORT1 Membrane protein, integral; Receptor, misc. Q99523 6272 1p13.3|1p21.3-p13.1 human S825-p 468808 KSGYHDDsDEDLLE_ protein stabilization; molecular association, regulation GGA1(INDUCES) 20015111; 25805502 5 43 23 +AURKB AurB EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, Other; Protein kinase, Ser/Thr (non-receptor) Q96GD4 9212 17p13.1 human K215-ac 54468601 LGLKGELkIADFGWS Pkinase molecular association, regulation; phosphorylation; enzymatic activity, induced cell cycle regulation PPP2CA(DISRUPTS) 26829474 1 1 0 +POLI POLI DNA repair, damage; EC 2.7.7.7; Transferase Q9UNA4 11201 18q21.2 human K533-ub 50771307 GVDQEVFkQLPVDIQ protein degradation 26370087 1 1 0 +WWC1 KIBRA Adaptor/scaffold Q8IX03 23286 5q34 human S539-p 20751200 TSLSPRSsLSSPSPP molecular association, regulation cell cycle regulation Merlin(INDUCES) 21878642; 22904328 3 0 0 +TLE1 TLE1 Nuclear receptor co-regulator; Transcription, coactivator/corepressor Q04724 7088 9q21.32 human S286-p 5707650 LKKDASSsPASTASS molecular association, regulation transcription, induced DNA(NOT_REPORTED) 19956621; 24270405 2 24 1 +Pgr PR DNA-binding; Nuclear receptor; Transcription factor Q00175 18667 9|9 A1 mouse S294-p 447987 SPIAPGRsPLATTVV Prog_receptor activity, induced; phosphorylation transcription, altered MSK1(INDUCES); ERK2(INDUCES); ERK1(INDUCES) 17081988 21 3 0 +SNRPB snRNP B1 RNA processing; RNA splicing; RNA-binding; Spliceosome P14678 6628 20p13 human R209-m2 476758 PMGIPPGrGTPMGMP molecular association, regulation SMN(INDUCES) 11720283 1 1 0 +CCNE2 CCNE2 Activator; Cell cycle regulation O96020 9134 8q22.1 human S396-p 4271425 GIMTPPKsTEKPPGK protein degradation; ubiquitination 19084516 1 0 1 +Epor EPOR Membrane protein, integral; Receptor, cytokine P14753 13857 9 A3|9 7.93 cM mouse Y367-p 449883 SEHAQDTyLVLDKWL molecular association, regulation carcinogenesis, induced; apoptosis, altered; cell differentiation, altered; cell growth, induced; cell growth, altered PLCG1(INDUCES) 11806992; 15953601; 16380376; 20028972; 27998978; 7541671; 8521813 17 0 0 activates Stat5 +BORA BORA Activator Q6PGQ7 79866 13q21.33 human S252-p 7533203 SSGQFSSsPIQASAK molecular association, regulation cell cycle regulation PLK1(INDUCES) 18521620; 34759346 2 4 1 +SRCIN1 SNIP Cytoskeletal Q9C0H9 80725 17q12 human Y396-p 456704 LVKGEGLyADPYGLL molecular association, regulation CSK(INDUCES) 23383002 1 18 217 +Rbpms RBPMS Motility/polarity/chemotaxis Q9WVB0 19663 8|8 A4 mouse T118-p 3208560 VGTPNPStPLPNTVP molecular association, regulation; activity, inhibited; phosphorylation RBPMS(DISRUPTS) RNA(DISRUPTS) 36408906 2 10 2 primes phosphorylation at T113 +IL6ST gp130 Membrane protein, integral; Receptor, cytokine P40189 3572 5q11.2 human S782-p 448180 QVFSRSEsTQPLLDS receptor internalization, induced; protein degradation; receptor internalization, altered transcription, inhibited; signaling pathway regulation 10811661; 15786731; 22306348 4 5 0 +Prkdc DNAPK DNA repair, damage; EC 2.7.11.1; KINASE; Kinase, protein; Nucleolus; Protein kinase, Ser/Thr (non-receptor); Protein kinase, atypical P97313 19090 16 10.09 cM|16 A2 mouse T2605-p 448710 LTPMFIEtQASPSIL DNAPKcs_CC5 DNA repair, induced 37307443 36 8 22 contributes to the synergy between XLF and DNA-PKcs in end-ligation, sites have distinct moderate roles in NHEJ +Prkch PKCH EC 2.7.11.13; KINASE; Kinase, protein; Protein kinase, AGC; Protein kinase, Ser/Thr (non-receptor) P23298 18755 12|12 C3 mouse S642-p 1239966008 IKSREDVsNFDPDFI Pkinase_C phosphorylation cell differentiation, induced; transcription, inhibited 30154443 1 0 0 inhibits transcription of E-cadherin, induces phosphorylation of Klf4 +Unc93b1 UNC93B1 Cell surface; Membrane protein, integral; Membrane protein, multi-pass Q8VCW4 54445 19|19 A mouse S550-p 3212118 EEDNSDEsDMEGEQG molecular association, regulation signaling pathway regulation syntenin(INDUCES) 31546246 1 25 4 inhibits TLR7 signaling +FAM50A FAM50A DNA-binding Q14320 9130 Xq28 human K5-m1 57984718 ___MAQYkGAASEAG molecular association, regulation L3MBTL iso4(INDUCES) 23583077 0 3 0 +Camk2a CAMK2A EC 2.7.11.17; KINASE; Kinase, protein; Protein kinase, CAMK; Protein kinase, Ser/Thr (non-receptor) P11798 12322 18 E1|18 34.41 cM mouse T337-p 481032 SSESTNTtIEDEDTK molecular association, regulation; enzymatic activity, inhibited NMDAR2B(DISRUPTS); Calmodulin(DISRUPTS) 28636948 1 10 12 regulates LTP, fear memory, spatial learning +TUBA1A TUBA1A Cytoskeletal; Motility/polarity/chemotaxis Q71U36 7846 12q13.12 human K96-sm 55461538 PEQLITGkEDAANNY Tubulin sumoylation cytoskeletal reorganization 33394042 1 2 0 promotes microtubule catastrophe, attenuates MT polymerization, facilitates neurite extension +PFKFB3 PFKFB3 Carbohydrate Metabolism - fructose and mannose; EC 2.7.1.105; EC 3.1.3.46; KINASE; Kinase, other; Motility/polarity/chemotaxis; PHOSPHATASE; Phosphatase (non-protein) Q16875 5209 10p15.1 human S467-p 468406 NSVTPLAsPEPTKKP cell growth, induced 29967256 2 27 30 CDK6 phosphorylation of PFKFB3 may regulate glucose metabolism and be involved in breast cancer +Itpr2 IP3R2 Channel, calcium; Channel, ligand-gated; Membrane protein, integral; Membrane protein, multi-pass P29995 rat S150-p 26415703 EKNAMRVsLDAAGNE Ins145_P3_rec activity, inhibited 23019322 1 0 0 phosphorylation channel modulation (open probability is decreased) +HNRNPK hnRNP K RNA splicing; RNA-binding; Spliceosome P61978 3190 9q21.32 human S353-p 450147 DSAIDTWsPSEWQMA activity, induced; intracellular localization translation, altered; cell growth, induced; transcription, induced; transcription, altered 11231586; 11259409; 24236111 4 1 0 localized to nuclear matrix +EIF4EBP1 4E-BP1 Translation; Translation initiation Q13541 1978 8p11.23 human S83-p 447525 PTIPGVTsPSSDEPP eIF_4EBP intracellular localization carcinogenesis, induced 27402756 7 9 0 colocalizes with centrosomes during mitosis, cell transformation +Mafa MAFA DNA-binding; Oncoprotein; Transcription factor; Tumor suppressor Q8CF90 378435 15|15 D3 mouse S49-p 1320400 CHRLPPGsLSSTPLS protein degradation; molecular association, regulation transcription, inhibited MAFA(INDUCES); PSME3(INDUCES) DNA(NOT_REPORTED) 20208071; 21646385 4 1 0 +RSF1 HBXAP Transcription, coactivator/corepressor Q96T23 51773 11q14.1 human S1375-p 3088513 LPSTNGQsPGKAIEN phosphorylation cell cycle regulation 26259146 1 50 4 phosphorylation of this site facilitates the subsequent phosphorylation by Plk1 at S1359; plays a role in PLK1 recruitment and deposition on mitotic kinetochores +GCSAM GCET2 Unknown function Q8N6F7 257144 3q13.2 human Y128-p 463674 LGGTETEySLLHMPS HGAL activity, induced signaling pathway regulation 31362927 3 2 1 regulates B cell receptor signaling +CCNT1 CCNT1 Cell cycle regulation; Transcription initiation complex O60563 904 12q13.11-q13.12 human K404-ac 9263557 AEELAAQkRQLENME molecular association, regulation; enzymatic activity, induced transcription, induced BCDIN3(DISRUPTS); HEXIM1(DISRUPTS); BRD4(INDUCES) 19387490; 19828451 2 1 2 enhances CDK9/cyclin T1 transcriptional activity, disrupting HEXIM1 and BCDIN3 association +Trim28 TIF1B EC 6.3.2.-; KINASE; Kinase, protein; Ligase; Nuclear receptor co-regulator; Protein kinase, atypical; SUMO LIGASE; SUMO ligase; Transcription, coactivator/corepressor; UBIQUITIN LIGASE; Ubiquitin conjugating system; Ubiquitin ligase Q62318 21849 7|7 A1 mouse K804-sm 2798311 NDAFGDTkFSAVLVE transcription, inhibited 17298944 5 4 0 +FAS FAS Apoptosis; Cell surface; Membrane protein, integral; Receptor, cytokine P25445 355 10q23.31 human Y291-p 455222 LHGKKEAyDTLIKDL Death molecular association, regulation; intracellular localization apoptosis, altered FAS(INDUCES); FADD(INDUCES); CASP8(INDUCES) 15660394; 17195092 3 0 0 Y291 or Y232 is required for Fas oligomerization +TTK TTK Cancer Testis Antigen (CTA); EC 2.7.12.1; KINASE; Kinase, protein; Protein kinase, Other; Protein kinase, dual-specificity (non-receptor) P33981 7272 6q14.1 human K287-sm 52485003 NSPDCDVkTDDSVVP molecular association, regulation cell cycle regulation BUB1B(DISRUPTS) 26675261 1 0 0 +Siah2 SIAH2 EC 6.3.2.-; EC 6.3.2.19; Ligase; Transcription, coactivator/corepressor; UBIQUITIN LIGASE; Ubiquitin conjugating system; Ubiquitin ligase Q06986 20439 3 D|3 28.68 cM mouse T24-p 471340 KQPPPPQtPHAPSPA molecular association, regulation; intracellular localization EGLN3(INDUCES) 17003045 1 0 0 plays a role in degradation of endogenous EGLN3 (PHD3). +MAP4 MAP4 Cytoskeletal; Motility/polarity/chemotaxis P27816 4134 3p21.31 human K912-ac 62495527 DKKPTSAkPSSTTPR cytoskeletal reorganization 28002468 1 1 0 +KDM5B JARID1B Cancer Testis Antigen (CTA); DEMETHYLASE; Demethylase; EC 1.14.11.-; Oxidoreductase; Transcription, coactivator/corepressor Q9UGL1 10765 1q32.1 human K242-sm 31089530 RAEAMNIkIEPEETT molecular association, regulation; enzymatic activity, induced transcription, induced DNA(DISRUPTS) 23970103 1 2 0 regulates JARID1B demethylase activity +HRC HRC Calcium-binding; Contractile P23327 3270 19q13.33 human S96-p 34499322 EKEDEDVsKEYGHLL molecular association, regulation SERCA2(INDUCES); TRDN(INDUCES) 28784772 2 4 0 +CDC5L CDC5L DNA-binding; Motility/polarity/chemotaxis; RNA processing; RNA splicing; Spliceosome; Transcription factor Q99459 988 6p21.1 human T438-p 3210129 PKPVINStPGRTPLR Myb_Cef RNA splicing, altered 18583928 1 8 28 +ASB8 ASB8 Q9H765 140461 12q13.11 human S31-p 1868140200 RTIAAIRsFPHDNVE Ank_2 ubiquitination signaling pathway regulation 31009856 1 1 0 induces ubiquitination of IKKB; regulates NF-kB signaling pathway +DNER DNER Membrane protein, integral; Receptor, misc. Q8NFT8 92737 2q36.3 human Y721-p 473325 SPIAYEDySPDDKPL DNER_C intracellular localization 18474614 1 1 10 +ATP7A ATP7A Apoptosis; Cell development/differentiation; Chaperone; EC 3.6.3.54; Hydrolase; Membrane protein, integral; Membrane protein, multi-pass; Transporter; Transporter, ion channel; Vesicle Q04656 538 Xq21.1 human S1463-p 4733422 IVNYSRAsINSLLSD protein stabilization; intracellular localization 29301787 2 18 2 translocation to membrane +Tlr3 TLR3 Membrane protein, integral; Receptor, cytokine Q7TNI8 364594 16q11 rat Y760-p 450187 EQFEYTAyIIHAQKD TIR cell growth, induced; transcription, induced 24526685 4 0 0 +PIK3R1 PIK3R1 KINASE; Kinase, lipid; Motility/polarity/chemotaxis P23727 282307 cow T86-p 22881800 RKKISPPtPKPRPPR molecular association, regulation IRS1(DISRUPTS) 22158866 1 1 0 +MT-CO1 COX1 EC 1.9.3.1; Energy Metabolism - oxidative phosphorylation; Membrane protein, integral; Membrane protein, multi-pass; Mitochondrial; Oxidoreductase P00395 4512 - human K264-ac 1879877107 IVTYYSGkKEPFGYM apoptosis, induced 31647884 1 0 0 mutant sites were found to significantly suppressed the AAPH-evoked increase in both ROS level and apoptosis +THRB TR-beta1 DNA-binding; Nuclear receptor P10828 7068 3p24.2 human S142-p 449635 IQKNLHPsYSCKYEG zf-C4 molecular association, regulation transcription, altered SMRT(DISRUPTS); p300(INDUCES) 12809513 1 0 0 +IKBKB IKKB EC 2.7.11.10; KINASE; Kinase, protein; Protein kinase, Other; Protein kinase, Ser/Thr (non-receptor) O14920 3551 8p11.21 human S733-gl 6729303 TVREQDQsFTALDWS IKKbetaNEMObind carcinogenesis, induced 19202066 1 0 0 enhanced in transformed human fibroblasts, enhanced glucose metabolism +Asap1 DDEF1 GAP; GAP, ARF; Motility/polarity/chemotaxis Q9QWY8 13196 15|15 D1 mouse Y782-p 450438 RDKQRLSyGAFTNQI molecular association, regulation; activity, inhibited Other(DISRUPTS) 12771146; 16413287 5 0 0 modulates DDEF1 phospholipid binding as well as ARF1 GTPase activity; leads to less binding to phospholipids (including P(4,5)P2, PI(3,4,5)P3, and PI(3,4)P2) and less GAP activity toward Arf1 +KLF4 KLF4 C2H2-type zinc finger protein; DNA-binding; Transcription factor O43474 9314 9q31.2 human K278-sm 14988613 PRTCPKIkQEAVSSC cell differentiation, induced; transcription, inhibited 23515309 2 0 0 +MAGEA11 MAGE-A11 Cancer Testis Antigen (CTA); Transcription, coactivator/corepressor P43364 4110 Xq28 human K240-ub 2028408 LLRKYRVkGLITKAE MAGE protein degradation; molecular association, regulation; ubiquitination transcription, induced MAGE-A6(DISRUPTS) 23853093; 28542476 3 0 0 induce activation of E2F1; MageA6 interaction with MageA11 prevents MageA11 ubiquitination +Psmb3 PSMB3 Cell cycle regulation; EC 3.4.25.1; Protease; Proteasome complex Q9R1P1 26446 11 D|11 61.07 cM mouse K77-ac 475744 RLNLYELkEGRQIKP Proteasome protein degradation 24037710 0 8 9 +IKBKB IKKB EC 2.7.11.10; KINASE; Kinase, protein; Protein kinase, Other; Protein kinase, Ser/Thr (non-receptor) O14920 3551 8p11.21 human S258-p 31849417 GTVKFSSsLPYPNNL Pkinase protein degradation; ubiquitination carcinogenesis, induced; cell growth, induced 36923932 1 1 0 +GTF2I GTF2I DNA-binding; Transcription, coactivator/corepressor P78347 2969 7q11.23 human S412-p 457074 GIPFRRPsTYGIPRL GTF2I transcription, induced 12082086 2 11 139 +NDUFV1 NDUFV1 EC 1.6.5.3; EC 1.6.99.3; Energy Metabolism - oxidative phosphorylation; Mitochondrial; Oxidoreductase P49821 4723 11q13.2 human T383-p 33402200 HESCGQCtPCREGVD NADH_4Fe-4S activity, induced cell cycle regulation 24746669 1 1 0 increases mitochondrial respiration for G/2M transition +LATS1 LATS1 EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, AGC; Protein kinase, Ser/Thr (non-receptor); Tumor suppressor O95835 9113 6q25.1 human S464-p 451855 NIPVRSNsFNNPLGN protein degradation 19927127 1 50 9 +Npas4 NPAS4 DNA-binding Q8BGD7 225872 19|19 A mouse S615-p 1871095701 GLLTPEAsPVKQSFF molecular association, regulation neural plasticity; transcription, induced CBP(INDUCES) 31801086 1 1 0 +PARP1 PARP1 DNA repair, damage; EC 2.4.2.30; Nuclear envelope; Nuclear receptor co-regulator; Nucleolus; Transferase P09874 142 1q42.12 human K498-ac 459000 EVVAPRGkSGAALSK molecular association, regulation transcription, induced NFkB-p105(INDUCES) 16204234 1 1 0 +SNAPIN SNAPIN Vesicle O95295 23557 1q21.3 human S50-p 448453 HVHAVREsQVELREQ Snapin_Pallidin molecular association, regulation neural plasticity; exocytosis, induced RAPGEF4(INDUCES); VAMP2(INDUCES); TMEM27(INDUCES); SNAP-25(INDUCES) 15269257; 21356520 5 0 0 +PTK2 FAK EC 2.7.10.2; KINASE; Kinase, protein; Protein kinase, TK; Protein kinase, tyrosine (non-receptor) Q05397 5747 8q24.3 human T700-p 485788 MESRRQAtVSWDSGG phosphorylation; enzymatic activity, induced cell motility, induced; cell adhesion, inhibited 23264741 1 2 1 induces phosphorylation at S695 +PLK3 PLK3 EC 2.7.11.21; KINASE; Kinase, protein; Nucleolus; Protein kinase, Other; Protein kinase, Ser/Thr (non-receptor) Q9H4B4 1263 1p34.1 human T219-p 1869357200 PPEQRKKtICGTPNY Pkinase enzymatic activity, inhibited 32575753 1 0 0 +STXBP1 STXBP1 Vesicle P61764 6812 9q34.11 human S313-p 448744 SLKDFSSsKRMNTGE Sec1 molecular association, regulation exocytosis, induced STX1A(DISRUPTS) 25716318; 28983637 7 0 0 reduced vesicle association ; mast cell degranulation +RAD17 RAD17 Cell cycle regulation O75943 5884 5q13.2 human S359-p 23136916 RPRKKGMsLKSDAVL molecular association, regulation RAD1(INDUCES) 29902452 1 1 6 +HMGB1 HMGB1 DNA repair, damage; Nuclear receptor co-regulator P09429 3146 13q12.3 human K112-me 31094520 FCSEYRPkIKGEHPG HMG_box intracellular localization 24289579 1 1 0 localized to the cytoplasm +CSNK1A1 CK1A EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, CK1; Protein kinase, Ser/Thr (non-receptor) P48729 1452 5q32 human T169-p 1876579500 KKYRDNRtRQHIPYR Pkinase phosphorylation; enzymatic activity, induced carcinogenesis, induced; cell growth, induced; transcription, induced; signaling pathway regulation 35277657 1 0 0 induces QIK phosphorylation thereby inducing the Wnt/?-catenin signaling pathway +SLFN12 SLFN12 Unknown function Q8IYM2 55106 17q12 human S368-p 1876351800 TSLPAPHsWPLLEWQ enzymatic activity, inhibited RNA stability, induced 35104454 1 1 0 +Sgo2a SGOL2 Unknown function Q7TSY8 68549 1 C1.3|1 28.86 cM mouse T521-p 27462598 LSKPSRQtFVIRKSE intracellular localization 28502659 1 1 0 dissociation from chromosome arms +Psmd11 PSMD11 Protease; Proteasome complex Q8BG32 69077 11|11 B5 mouse S14-p 468525 VEFQRAQsLLSTDRE RPN6_N activity, induced; enzymatic activity, induced transcription, altered 30782827; 37641975 3 47 30 Increases proteosome activity; induces protease activities, decreases ubiquitin conjugates, induces degradation of misfolded proteins +Vim Vimentin Cytoskeletal; Motility/polarity/chemotaxis P20152 22352 2 A1|2 10.04 cM mouse S56-p 451514 SRSLYSSsPGGAYVT Filament_head molecular association, regulation carcinogenesis, induced; cell motility, induced Vimentin(DISRUPTS); PLK1(INDUCES) 16260496; 32193336 32 85 227 +USP16 USP16 DEUBIQUITINASE; EC 3.4.19.12; Protease; Ubiquitin conjugating system; Ubiquitin-specific protease Q9Y5T5 10600 21q21.3 human S552-p 449274 DLEVLTSsPTRNLNG UCH protein degradation; molecular association, regulation; intracellular localization cell cycle regulation PLK1(INDUCES); Exportin-1(DISRUPTS) 24013421; 26323689; 28380042 3 22 2 +IGF1R IGF1R EC 2.7.10.1; KINASE; Kinase, protein; Membrane protein, integral; Protein kinase, TK; Protein kinase, tyrosine (receptor) P08069 3480 15q26.3 human Y1281-p 450102 FREVSFYySEENKLP apoptosis, altered; cell differentiation, altered; cell growth, altered 10786694; 8972223 5 0 0 +ASAP3 DDEFL1 GAP; GAP, ARF; Motility/polarity/chemotaxis Q8TDY4 55616 1p36.12 human T545-p 181213000 HRFARRCtPEPQRLW molecular association, regulation; intracellular localization DDEFL1(INDUCES) 28808054 1 0 0 tubulovesicle and relocation of H,K-ATPase to the apical plasma membrane +PCSK7 PCSK7 EC 3.4.21.-; Membrane protein, integral; Protease Q16549 9159 11q23.3 human S505-p 1827354800 AIPQSPRsLEVLWNV protein stabilization 31945259 1 0 0 decreases TG levels +STK11 LKB1 Autophagy; EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, CAMK; Protein kinase, Ser/Thr (non-receptor); Tumor suppressor Q15831 6794 19p13.3 human T185-p 11454701 KPGNLLLtTGGTLKI Pkinase enzymatic activity, induced 12805220 1 0 0 STRAD increases LKB1 activation +Pth1r PTHR GPCR, family 2; Membrane protein, integral; Membrane protein, multi-pass; Receptor, GPCR P25961 56813 8q32 rat S504-p 2853101 GPMVSHTsVTNVGPR receptor internalization, altered; activity, inhibited 11773434; 18577695 3 1 0 +Map3k12 DLK EC 2.7.11.25; KINASE; Kinase, protein; Protein kinase, Ser/Thr (non-receptor); Protein kinase, TKL Q60700 26404 15|15 F3 mouse T43-p 4727854 CTPEKDLtPTQCVLR protein stabilization 23979718 1 5 0 +HDAC1 HDAC1 DEACETYLASE; Deacetylase; EC 3.5.1.98; Hydrolase; Nuclear receptor co-regulator Q13547 3065 1p35.2-p35.1 human S421-p 447912 IACEEEFsDSEEEGE molecular association, regulation; enzymatic activity, induced SIN3A(INDUCES) 11602581 1 71 40 +MAF1 MAF1 Transcription regulation Q9H063 84232 8q24.3 human S60-p 3211917 PHVLEALsPPQTSGL Maf1 activity, inhibited transcription, induced 20233713; 20516213 2 16 0 +TRPC4 TRPC4 Channel, calcium; Membrane protein, integral; Membrane protein, multi-pass Q9UBN4 7223 13q13.3 human Y959-p 456713 EEDSSIDyDLNLPDT activity, induced; intracellular localization NHERF(INDUCES) 16144838; 21427121 2 1 0 +Jup CTNNG Cytoskeletal; Motility/polarity/chemotaxis Q02257 16480 11 D|11 63.47 cM mouse S665-p 2048381 PDYRKRVsVELTNSL cell adhesion, induced 32841221 2 35 0 +Pla2g6 PLA2G6 EC 3.1.1.4; Lipid Metabolism - alpha-linolenic acid; Lipid Metabolism - arachidonic acid; Lipid Metabolism - ether lipid; Lipid Metabolism - glycerophospholipid; Lipid Metabolism - linoleic acid; Phospholipase P97570 360426 7q34 rat Y672-p 15512800 AMTEIHEyNQDMIRK molecular association, regulation Calnexin(INDUCES) 20732873 1 1 0 enzymatic activity of PLA2G6 increases upon incubation with calnexin +Pln PLB Inhibitor; Membrane protein, integral P61014 18821 10|10 B3 mouse T17-p 448115 SAIRRAStIEMPQQA Phospholamban activity, induced 11861420; 15276030; 21888910; 33941260 75 12 63 induces SERCA2A activity; induces SERCA activity; regulates myocyte contraction and relaxation.; increase in calcium spark frequency and size +Mapk7 ERK5 EC 2.7.11.24; KINASE; Kinase, protein; Protein kinase, CMGC; Protein kinase, Ser/Thr (non-receptor) Q9WVS8 23939 11|11 B2 mouse T219-p 448205 AEHQYFMtEYVATRW Pkinase carcinogenesis, induced; cell adhesion, induced; signaling pathway regulation 33687949 20 2 31 ERK5/ P70S6K/RAC1 pathway +TBX22 TBX22 DNA-binding Q9Y458 50945 Xq21.1 human K271-sm 2798304 NQQITKLkIERNPFA T-box transcription, inhibited 17846996 1 0 0 +ZIC3 ZIC3 C2H2-type zinc finger protein; DNA-binding; Transcription factor O60481 7547 Xq26.3 human K248-sm 31094500 RYMRQPIkQELSCKW zf_ZIC intracellular localization 23872418 1 0 0 +NF2 Merlin Cytoskeletal; Motility/polarity/chemotaxis; Tumor suppressor P35240 4771 22q12.2 human K274-ub 1878191200 SDKEFTIkPLDKKID molecular association, regulation; intracellular localization LATS1(DISRUPTS) 30918126 1 1 0 K63 kinked +Hmgb1 HMGB1 DNA repair, damage; Nuclear receptor co-regulator P63159 25459 19q12 rat K82-ac 460592 MKTYIPPkGETKKKF phosphorylation DNA(INDUCES) 19166815; 21647302 5 4 0 acetylated residues inhibit it's phosphorylation +CAPZB CAPZB iso1 Actin-binding; Motility/polarity/chemotaxis P47756-1 832 1p36.13 human S226-p 27445587 DMENKIRsTLNEIYF F_actin_cap_B cell motility, induced; cell adhesion, induced; cytoskeletal reorganization 32771000 1 2 0 +STIL STIL Cell cycle regulation; Cell development/differentiation; Oncoprotein Q15468 6491 1p33 human S395-p 23149233 MPIHDHDsGVEDEDF STIL_N protein degradation; molecular association, regulation; ubiquitination BTRC(INDUCES) 29445034 1 6 5 +MYC Myc DNA-binding; Nucleolus; Oncoprotein; Transcription factor P01106 4609 8q24.21 human K386-ac 458887 RQRRNELkRSFFALR HLH molecular association, regulation ZBTB17(INDUCES) 16126174 2 2 0 induces association with ZBTB17 on specific target promoters +Pxn PXN Adaptor/scaffold; Cell adhesion; Cytoskeletal; Motility/polarity/chemotaxis Q8VI36 19303 5 F|5 56.1 cM mouse T572-p 465506 LKQLNKGtFKEQNDK LIM cytoskeletal reorganization; cell adhesion, altered 20388733 1 1 0 leads to depolymerization of the actin cytoskeleton and activation of LFA-1 integrins +Rdx Radixin Cytoskeletal; Motility/polarity/chemotaxis P26043 19684 9|9 A5.3 mouse T564-p 448374 AGRDKYKtLRQIRQG ERM_C molecular association, regulation; intracellular localization cell motility, altered; cytoskeletal reorganization Radixin(INDUCES) 19890007; 19913059; 24250818; 9456324 21 7 16 iincreased filopodia with phosphorylated ERM proteins; membrane protrusion +Gabrb1 GABRB1 Channel, chloride; Channel, ligand-gated; Membrane protein, integral; Membrane protein, multi-pass; Transporter; Transporter, ion channel P50571 14400 5 C3.2|5 38.18 cM mouse S434-p 450244 GRIRRRAsQLKVKIP Neur_chan_memb receptor desensitization, altered 14684872 7 1 0 GABRB3 S432 demonstrated to play no noticeable role in the desensitization via PKA. +Mapt Tau ACETYLTRANSFERASE; Acetyltransferase; Cytoskeletal P10637 17762 11 67.79 cM|11 E1 mouse S688-p 449081 GAEIVYKsPVVSGDT molecular association, regulation; intracellular localization; protein conformation; phosphorylation neural plasticity SNCA(INDUCES) 21445308; 24653715; 27834631; 31645758; 34453977; 35668361 192 49 90 +MAT2A MAT2A Amino Acid Metabolism - cysteine and methionine; EC 2.5.1.6; Other Amino Acids Metabolism - selenoamino acid; Transferase P31153 4144 2p11.2 human K394-sm 50455002 WEVPKKLkY______ protein stabilization; molecular association, regulation cell growth, induced; apoptosis, inhibited; transcription, induced Bcl-2(INDUCES) DNA(INDUCES) 26416353 1 0 0 +H2AX H2AX DNA repair, damage; DNA-binding; Helicase P16104 3014 11q23.3 human K134-m2 37036405 KAPSGGKkATQASQE molecular association, regulation; phosphorylation carcinogenesis, induced ATM(INDUCES) 25487737 1 1 0 increases phosphorylation at H2AX at S139 +SPTA1 SPTA1 Cytoskeletal; Motility/polarity/chemotaxis P02549 6708 1q23.1 human Y1499-p 6211807 ERTKLGDyANLKQFY cytoskeletal reorganization 20206558 1 1 0 +A1cf ACF Hydrolase; RNA processing; RNA-binding Q923K9 170912 1q52 rat S154-p 473053 KKREEILsEMKKVTE RRM_1 activity, induced 17229474 1 0 0 enhances ApoB mRNA editing +MAP2K1 MEK1 EC 2.7.12.2; KINASE; Kinase, protein; Protein kinase, STE; Protein kinase, dual-specificity (non-receptor) Q02750 5604 15q22.31 human K104-sm 35480410 KLIHLEIkPAIRNQI Pkinase molecular association, regulation; enzymatic activity, inhibited cell differentiation, inhibited; cell growth, inhibited; signaling pathway regulation ERK2(DISRUPTS) 21336309 1 1 0 downregulates ERK signaling +Tacc3 TACC3 Cell cycle regulation Q9JJ11 21335 5|5 B2 mouse S347-p 474537 ESAWRKQsLYVKFDP intracellular localization cell cycle regulation 20838383 12 15 43 +NFE2L2 NRF2 DNA-binding; Transcription factor Q16236 4780 2q31.2 human S356-p 18258502 NTSPSVAsPEHSVES protein degradation; molecular association, regulation BTRC(DISRUPTS) 22751928; 32295843 3 1 0 +BMAL1 BMAL1 DNA-binding; Transcription factor O00327 406 11p15.3 human T21-p 12575204 DFMSPGPtDLLSSSL protein degradation transcription, altered 20049328 1 0 0 stabilization of BMAL1 protein leads to reduction in its transcription activation ability +Kcnab2 Kv-beta2 Channel, potassium P62483 29738 5q36 rat S31-p 3996100 IYSTRYGsPKRQLQF activity, induced; molecular association, regulation; intracellular localization EB1(DISRUPTS) 21357749 2 2 0 +FUS hnRNP P2 DNA-binding; Nuclear receptor co-regulator; Oncoprotein; RNA splicing; RNA-binding; SUMO LIGASE P35637 2521 16p11.2 human T11-p 179463706 NDYTQQAtQSYGAYP molecular association, regulation 28942918 2 1 0 strongly reduced the effects of DNA-PK treatment on both hydrogel binding and droplet formation +KIF2C KIF2C Cancer Testis Antigen (CTA); Microtubule-binding; Motility/polarity/chemotaxis; Motor Q99661 11004 1p34.1 human S111-p 25159900 KESLRSRsTRMSTVS molecular association, regulation; intracellular localization; activity, inhibited cytoskeletal reorganization EB1(DISRUPTS) 14960279; 19632184; 23055517 3 2 6 involved in microtubule tip tracking +CHEK1 Chk1 EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, CAMK; Protein kinase, Ser/Thr (non-receptor); Tumor suppressor O14757 1111 11q24.2 human S301-p 465528 IQSNLDFsPVNSASS intracellular localization cell cycle regulation 18983824; 21907702 5 22 5 +CLEC4D CLEC4D Membrane protein, integral Q8WXI8 338339 12p13.31 human K9-ub 56836806 GLEKPQSkLEGGMHP protein degradation 27432944 1 0 0 negative regulation of antifungal immune response +Stx7 STX7 Membrane protein, integral; Vesicle O70439 53331 10|10 A4 mouse S126-p 468881 VARVRASsRVSGGFP molecular association, regulation STX8(INDUCES); VTI1B(INDUCES); VAMP8(INDUCES) 18710945 1 17 158 +SIK1 SIK EC 2.7.11.1; KINASE; Kinase, protein; Motility/polarity/chemotaxis; Protein kinase, CAMK; Protein kinase, Ser/Thr (non-receptor); Tumor suppressor P57059 150094 21q22.3 human S575-p 465992 FQEGRRAsDTSLTQG intracellular localization 22462548 10 21 4 +BRAF BRAF EC 2.7.11.1; KINASE; Kinase, protein; Oncoprotein; Protein kinase, Ser/Thr (non-receptor); Protein kinase, TKL P15056 673 7q34 human S579-p 456814 IIHRDLKsNNIFLHE PK_Tyr_Ser-Thr enzymatic activity, induced 16093354 1 0 0 mutation of T481 is less profound of an effect. B-Raf S579 shows similar effects to Raf1 S471.; Mutation of Raf1 S471 abolishes kinase activity and EGF-induced activity +Mapk3 ERK1 EC 2.7.11.24; KINASE; Kinase, protein; Protein kinase, CMGC; Protein kinase, Ser/Thr (non-receptor) Q63844 26417 7 F3|7 69.25 cM mouse Y205-p 447543 HTGFLTEyVATRWYR Pkinase intracellular localization; enzymatic activity, induced cell cycle regulation; carcinogenesis, induced; carcinogenesis, inhibited; apoptosis, induced; cell motility, induced; cell growth, inhibited; cell motility, inhibited; transcription, induced; signaling pathway regulation; transcription, altered; neural plasticity; cell growth, induced; apoptosis, inhibited; cytoskeletal reorganization; transcription, inhibited 10867029; 11934884; 12446705; 15788406; 15975986; 16103085; 19004831; 21562256; 21706057; 21813649; 21887248; 21917714; 25584415; 34118691; 34191798; 34520454; 34617326; 35085550; 35857631; 36070687; 36088505; 36310322; 36736425; 37160873; 37430253 1366 142 3549 +EIF2AK2 PKR EC 2.7.10.2; EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, Other; Protein kinase, Ser/Thr (non-receptor); Protein kinase, tyrosine (non-receptor); Translation P19525 5610 2p22.2 human T446-p 448088 LKNDGKRtRSKGTLR Pkinase protein conformation; phosphorylation; enzymatic activity, induced cell cycle regulation; apoptosis, induced; translation, induced; cell growth, altered 11432733; 15880455; 16179258; 35354045; 35947956; 9528799 17 1 0 +Gpr35 GPR35 GPCR, family 1; Membrane protein, integral; Membrane protein, multi-pass; Receptor, GPCR Q9ES90 64095 1|1 D mouse S298-p 1876282808 SSNTPHKsQDSQILS molecular association, regulation; intracellular localization ARR3(INDUCES) 35101446 1 1 0 +Ptpn12 PTP-PEST EC 3.1.3.48; Motility/polarity/chemotaxis; PHOSPHATASE; Protein phosphatase, tyrosine (non-receptor) P35831 19248 5|5 A3 mouse S434-p 451312 KKLERNLsFEIKKVP molecular association, regulation SKAP2(INDUCES) 23897807 3 57 41 +KAT5 Tip60 ACETYLTRANSFERASE; Acetyltransferase; EC 2.3.1.48; Nuclear receptor co-regulator; Nucleolus Q92993 10524 11q13.1 human K148-ac 52498003 QPNHRSTkRKVEVVS protein degradation; intracellular localization apoptosis, altered 25301942 1 0 0 HDAC3 increased the TIP60 half-life, and the ubiquitination level of TIP60, nuclear localization, cytoplasm and nucleus with HDAC3 expressed, TIP60 deacetylation increases its resistance to apoptosis +Il17rb IL17RB Membrane protein, integral Q9JIP3 50905 14 B|14 18.39 cM mouse Y454-p 40427500 GADLKGDyNALSVCP SEFIR molecular association, regulation STAT5A(INDUCES) 25821217 1 0 0 +SSU72 SSU72 EC 3.1.3.16; PHOSPHATASE; Phosphatase Q9NP77 29101 1p36.33 human S19-p 29614601 CSSNQNRsMEAHNIL Ssu72 protein degradation; ubiquitination; enzymatic activity, inhibited; protein conformation cell cycle regulation; chromatin organization, altered 24149858 1 0 0 Regulation of sister chromatid arm cohesion during early mitosis +MAP4 MAP4 Cytoskeletal; Motility/polarity/chemotaxis P27816 4134 3p21.31 human K702-ac 62495526 PSPEKKTkPLATTQP cytoskeletal reorganization 28002468 1 1 0 +SESN2 SESN2 P58004 83667 1p35.3 human S73-p 1869992401 GLEALMSsGRVDNLA PA26 molecular association, regulation; intracellular localization autophagy, induced ATP5A1(INDUCES) 32854424 1 1 0 +CSNK1A1 CK1A EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, CK1; Protein kinase, Ser/Thr (non-receptor) P48729 1452 5q32 human K225-ub 15386532 SLPWQGLkAATKKQK Pkinase protein degradation 26909574 1 5 1 +TDP1 TDP1 DNA repair, damage; EC 3.1.4.-; Phosphodiesterase Q9NUW8 55775 14q32.11 human S563-p 460794 KQKFFAGsQEPMATF Tyr-DNA_phospho molecular association, regulation LIG3(INDUCES) 34181949 2 2 7 +H2AFZ H2AZ DNA-binding Q5ZMD6 426361 chicken K11-ac 465514 KAGKDSGkTKTKAVS Histone chromatin organization, altered 19385636 4 13 417 K4, K7, and K11 acetylation destabilizes the nucleosome core particle (NCP) +OPRK1 KOR-1 GPCR, family 1; Membrane protein, integral; Membrane protein, multi-pass; Receptor, GPCR P41145 4986 8q11.23 human K338-ub 1975302 AFLDENFkRCFRDFC receptor internalization, induced; protein degradation 18212250 1 0 0 ubiquitination regulates but is not required for receptor downregulation +ARRDC4 ARRDC4 Unknown function Q8NCT1 91947 15q26.2 human K270-ub 1883454300 STDTWNGkTLKIPPV Arrestin_C activity, induced; protein stabilization; intracellular localization 35106941 1 1 0 trafficking of EV's +CDK10 CDK10 Cell cycle regulation; EC 2.7.11.22; KINASE; Kinase, protein; Protein kinase, CMGC; Protein kinase, Ser/Thr (non-receptor) Q15131 8558 16q24.3 human T133-p 27422500 SLLENMPtPFSEAQV Pkinase molecular association, regulation PIN1(INDUCES) 22158035 1 0 0 +MAP2K1 MEK1 EC 2.7.12.2; KINASE; Kinase, protein; Protein kinase, STE; Protein kinase, dual-specificity (non-receptor) Q02750 5604 15q22.31 human K362-ac 35480412 LMVHAFIkRSDAEEV enzymatic activity, induced cell growth, induced; transcription, induced 24681949 2 0 0 +WWTR1 TAZ Oncoprotein; Transcription, coactivator/corepressor Q9GZV5 25937 3q25.1 human S89-p 457660 AQHVRSHsSPASLQL protein degradation; molecular association, regulation; intracellular localization; activity, inhibited carcinogenesis, inhibited; cell growth, inhibited; transcription, induced; cell motility, inhibited; transcription, inhibited; transcription, altered 14-3-3 beta(INDUCES); NEK8(DISRUPTS) 20412773; 22078877; 23026745; 26375055; 33086783; 33545120; 34465890; 34859820; 36077517; 37337213 31 20 79 +Nr2c1 NR2C1 DNA-binding; Nuclear receptor Q505F1 22025 10 C2|10 48.81 cM mouse S568-p 456552 IGNVRIDsVIPHILK protein stabilization transcription, altered 16130175 1 0 0 +YAP1 YAP1 iso2 Oncoprotein; Transcription, coactivator/corepressor P46937-2 10413 11q22.1 human T396-p 23939103 SSYSVPRtPDDFLNS apoptosis, inhibited; transcription, induced 22308035 3 5 2 YAP phosphorylation is required for anti-apoptotic activity of YAP in cells which are deficient in p73 alpha/beta expression. +CNKSR1 CNK1 Adaptor/scaffold; G protein regulator, misc. Q969H4 10256 1p36.11 human Y519-p 50402001 PPREEDCySETEAED intracellular localization transcription, inhibited 26319181 1 1 0 +Bnip3 BNIP3 Membrane protein, integral; Mitochondrial Q9ET45 84480 1q41 rat T66-p 4698307 DSPPRSQtPQDTNRA BNIP3 protein stabilization; molecular association, regulation; ubiquitination autophagy, induced LC3B(INDUCES); ubiquitin(DISRUPTS) 36396625 1 12 0 inhibits ubiquitination, induces mitophagy +RB1 Rb Nuclear receptor co-regulator; Oncoprotein; Transcription, coactivator/corepressor; Tumor suppressor P06400 5925 13q14.2 human S612-p 447977 MYLSPVRsPKKKGST molecular association, regulation; protein conformation cell differentiation, induced; apoptosis, induced; transcription, altered E2F1(DISRUPTS); E2F1(INDUCES) 17380128; 20223825; 24466208; 9315635 13 18 33 +Coro1a coronin 1A Cytoskeletal; Motility/polarity/chemotaxis O89053 12721 7 69.25 cM|7 F3 mouse T418-p 4701031 DSARRRAtPEPSGTP Trimer_CC cell motility, altered; cytoskeletal reorganization 20937706 1 19 3 +NFE2L2 NRF2 DNA-binding; Transcription factor Q16236 4780 2q31.2 human K555-ac 7106313 KSLHLLKkQLSTLYL bZIP_Maf molecular association, regulation transcription, induced DNA(INDUCES) 19273602 1 1 0 +Irak1 IRAK1 EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, Ser/Thr (non-receptor); Protein kinase, TKL Q62406 16179 X A7.3|X 37.61 cM mouse T66-p 447722 CERSEQRtASVLWPW Death molecular association, regulation; enzymatic activity, induced transcription, altered PKCI(INDUCES) 14684752 3 0 0 autophosphorylation activity +Trhr TRHR GPCR, family 1; Membrane protein, integral; Membrane protein, multi-pass; Receptor, GPCR Q01717 25570 7q31 rat S355-p 1229702 YSVALNYsVIKESDR receptor internalization, altered 17989235; 20345371 3 0 0 +BUB1 BUB1 Cell cycle regulation; EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, Other; Protein kinase, Ser/Thr (non-receptor) O43683 699 2q13 human S314-p 481705 SHEDLPAsQERSEVN enzymatic activity, induced cell cycle regulation; DNA repair, induced 22071147; 22099307 4 5 0 required for the spindle checkpoint activation +PSME3 PSME3 Nuclear receptor co-regulator; Protease; Proteasome complex P61289 10197 17q21.31 human K14-sm 25344502 VDQEVKLkVDSFRER PA28_alpha protein stabilization; intracellular localization; enzymatic activity, induced 21445096 1 0 0 +ELF3 ELF3 DNA-binding; Motility/polarity/chemotaxis; Transcription factor P78545 1999 1q32.1 human S68-p 54363505 GEQPQFWsKTQVLDW SAM_PNT intracellular localization cell growth, induced; transcription, induced 26977885 1 1 0 nuclear localization, NOTCH3 expression +Slc22a1 SLC22A1 Membrane protein, integral; Membrane protein, multi-pass; Transporter; Transporter, SLC family Q63089 24904 1q11 rat S292-p 455611 ESPRWLLsQKRTTRA Sugar_tr activity, induced 15829703 1 0 0 stimulates ASP+ uptake +Tp53 p53 Activator; DNA-binding; Motility/polarity/chemotaxis; Nuclear receptor co-regulator; Transcription factor; Tumor suppressor P02340 22059 11 B3|11 42.83 cM mouse K162-ac 59149205 RAMAIYKkSQHMTEV P53 cell cycle regulation; carcinogenesis, inhibited; apoptosis, induced 33303641 2 0 0 senescence, ferroptosis, failed to develop early-onset tumors +Bmpr1a BMPR1A EC 2.7.11.30; KINASE; Kinase, protein; Membrane protein, integral; Protein kinase, Ser/Thr (receptor); Protein kinase, TKL P36895 12166 14 B|14 20.81 cM mouse Y457-p 25655000 VEEYQLPyYNMVPSD PK_Tyr_Ser-Thr molecular association, regulation cell growth, induced; signaling pathway regulation BMPR2(INDUCES); TAB1(DISRUPTS) 22729085 1 1 0 regulation of BMP downstream pathways-Erk1/2 and Smad1 activation, regulates life span of osteoblasts (expansion) +FSCN1 fascin Actin-binding; Cytoskeletal; Motility/polarity/chemotaxis Q16658 6624 7p22.1 human K42-ub 8106235 ASASSLKkKQIWTLE Fascin cytoskeletal reorganization 27879315 1 1 1 fascin bundling activity +WASF3 WASF3 Actin-binding; Motility/polarity/chemotaxis Q9UPY6 10810 13q12.13 human Y486-p 486451 SRRIAVEySDSDDDS cell motility, induced; cytoskeletal reorganization 17623672 1 0 0 induces lamellipodia formation +TRPV4 TRPV4 Channel, cation; Membrane protein, integral; Membrane protein, multi-pass Q9HBA0 59341 12q24.11 human T813-p 1868023603 QYYGFSHtVGRLRRD activity, induced 32186440 1 0 0 +UHRF1 UHRF1 DNA-binding; EC 6.3.2.-; EC 6.3.2.19; Ligase; Transcription factor; UBIQUITIN LIGASE; Ubiquitin conjugating system; Ubiquitin ligase Q96T88 29128 19p13.3 human K648-ac 1883407602 RTGKGKWkRKSAGGG cell cycle regulation; cell growth, induced 35951156 1 0 0 +Adam17 TACE EC 3.4.24.86; Membrane protein, integral; Motility/polarity/chemotaxis; Protease Q9Z0F8 11491 12 A1.3|12 8.3 cM mouse S794-p 449040 NSSTAAKsFEDLTDH molecular association, regulation; enzymatic activity, induced PLK2(INDUCES) 24338472 4 54 0 facilitates the sheddase activity of TACE +MFF MFF Membrane protein, integral; Mitochondrial Q9GZY8 56947 2q36.3 human K151-ub 1877722300 IRAVGRLkRERSMSE Miff protein degradation 31112535 1 0 0 PARK2 mediated lysosomal degradation of MFF +Il1rl1 IL1RL1 Membrane protein, integral; Receptor, cytokine P14719 17082 1 B|1 19.19 cM mouse S442-p 25585004 AATVVESsIQNSRRQ TIR receptor internalization, induced; protein degradation; molecular association, regulation FBXL19(INDUCES) 22660580; 25472995 2 0 0 +CDC34 CDC34 EC 6.3.2.19; Ligase; UBIQUITIN LIGASE; Ubiquitin conjugating system; Ubiquitin ligase P49427 997 19p13.3 human S236-p 448690 DDSGTEEs_______ intracellular localization 11546811 2 0 0 +PKLR PKLR iso2 Carbohydrate Metabolism - glycolysis and gluconeogenesis; Carbohydrate Metabolism - pyruvate; EC 2.7.1.40; Kinase, other; Nucleotide Metabolism - purine P30613-2 5313 1q22 human S12-p 1218250 AGYLRRAsVAQLTQE molecular association, regulation; protein conformation Other(DISRUPTS) 22052499; 23270483 5 1 6 disrupts binding with phospho enol pyruvate; energetic coupling of S12 phosphorylation and oxidation of Cys 436 to phosphoethanolamine binding +NFKBIA IkB-alpha DNA-binding; Inhibitor P25963 4792 14q13.2 human S32-p 448203 LLDDRHDsGLDSMKD protein degradation; protein stabilization; molecular association, regulation; phosphorylation; activity, induced; sumoylation; ubiquitination; intracellular localization apoptosis, altered; cell growth, induced; apoptosis, induced; apoptosis, inhibited; transcription, induced; signaling pathway regulation; transcription, altered IkB-beta(INDUCES); AurC(INDUCES) 10096573; 10723127; 10754328; 10882136; 11350057; 11502888; 11724787; 11752211; 11753679; 12068083; 12085227; 12138192; 12419817; 12432072; 12527907; 14523047; 15470067; 15843586; 16007147; 16163708; 16735506; 20385620; 20696840; 28467781; 29050234; 32416562; 33572115; 33876201; 33941613; 34558646; 34965427; 36292785; 36528060; 7739562; 7796813; 7878466; 8649784; 8657102; 9252186; 9351830; 9724653; 9734360 161 3 17 +Elk1 ELK1 DNA-binding; Transcription factor A4GTP4 314436 Xq11 rat K248-sm 3982500 RPQPPEVkVEGPKEE apoptosis, inhibited; transcription, inhibited 30849179 6 1 0 GADD45A expression; APP/PS1 rats +Yy1 YY1 C2H2-type zinc finger protein; Cell development/differentiation; Transcription factor Q00899 22632 12 F1|12 59.58 cM mouse S365-p 15416769 EGCGKRFsLDFNLRT zf-C2H2 molecular association, regulation; phosphorylation transcription, induced; signaling pathway regulation CBX4(DISRUPTS) 22482732 2 5 3 +Myo3b MYO3B Actin-binding; EC 2.7.11.1; KINASE; Kinase, protein; Motor; Protein kinase, STE; Protein kinase, Ser/Thr (non-receptor) Q1EG27 329421 2|2 C2 mouse S887-p 36841907 KITASSRsLPPHFSA Myosin_head enzymatic activity, induced 21895655 1 1 0 +RBBP8 CtIP EC 3.1.-.-; Transcription, coactivator/corepressor Q99708 5932 18q11.2 human S231-p 33625700 VADTYDQsQSPMAKA enzymatic activity, induced 24837676 1 1 0 +NR4A2 NR4A2 DNA-binding; Nuclear receptor P43354 4929 2q24.1 human S126-p 487424 SVYYKPSsPPTPTTP intracellular localization transcription, induced 17681692; 24223135 3 0 0 +CLIP1 Restin Cytoskeletal P30622 6249 12q24.31 human S195-p 468616 LTKTASEsISNLSEA intracellular localization; phosphorylation 20664522 2 56 33 enhances phosphorylation of S1353 +SPAG5 SPAG5 Cell cycle regulation Q96R06 10615 17q11.2 human S249-p 460404 PSSVLWLsPSTALAA intracellular localization cell cycle regulation 27325694 1 10 0 localization and formation of kinetochores +Pak1 PAK1 EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, STE; Protein kinase, Ser/Thr (non-receptor) P35465 29431 1q32 rat T422-p 448177 PEQSKRStMVGTPYW Pkinase molecular association, regulation; enzymatic activity, induced cytoskeletal reorganization N-WASP(INDUCES) 11278486; 28972183 39 4 11 +Nfkbia IkB-alpha DNA-binding; Inhibitor Q9Z1E3 18035 12|12 C1 mouse S293-p 451525 EESYDTEsEFTEDEL protein degradation 8668171 3 0 0 S293 phosphorylation is required for rapid proteolysis of the unassociated protein. +SMAD4 SMAD4 DNA-binding; Nuclear receptor co-regulator; Transcription, coactivator/corepressor Q13485 4089 18q21.2 human T265-p 36694101 ATYHHNStTTWTGSR protein degradation; molecular association, regulation; ubiquitination carcinogenesis, inhibited; transcription, inhibited; signaling pathway regulation BTRC(INDUCES) 25373906 1 0 0 +FOXO3 FOXO3A Autophagy; DNA-binding; Oncoprotein; Transcription factor O43524 2309 6q21 human S644-p 451438 GLDFNFDsLISTQNV FOXO-TAD protein degradation; intracellular localization; activity, inhibited cell cycle regulation; apoptosis, inhibited; transcription, inhibited 15084260; 23691078 3 0 0 nuclear to cytoplasm transport, repressed FOXO3A-induced p27 promoter activity +NUPR1 NUPR1 Apoptosis; Cell cycle regulation; Cell development/differentiation O60356 26471 16p11.2 human T68-p 1870426000 GHERKLVtKLQNSER Phospho_p8 molecular association, regulation; protein conformation KPNA4(DISRUPTS) 32933064 1 0 0 +SIAH1 SIAH1 Apoptosis; Cell development/differentiation; EC 6.3.2.-; EC 6.3.2.19; Ligase; Motility/polarity/chemotaxis; UBIQUITIN LIGASE; Ubiquitin conjugating system; Ubiquitin ligase Q8IUQ4 6477 16q12.1 human T235-p 36694106 NGHRRRLtWEATPRS Sina molecular association, regulation; acetylation; intracellular localization signaling pathway regulation GAPDH(INDUCES) 25391652 1 0 0 augments p300 acetylation; nuclear translocation +HSPA5 GRP78 Chaperone; Heat shock protein; KINASE P11021 3309 9q33.3 human K376-ac 466066 PKIQQLVkEFFNGKE HSP70 molecular association, regulation; phosphorylation apoptosis, induced; signaling pathway regulation PERK(DISRUPTS) 20371724 1 3 5 induces phosphorylation of elf2a and activation of eIf2a-ATF4-CHOP pathway +Usf1 USF1 DNA-binding; Transcription factor Q61069 22278 1 H3|1 79.4 cM mouse S262-p 7367003 RQSNHRLsEELQGLD molecular association, regulation; acetylation transcription, altered SREBP-1(INDUCES) 19303849 2 1 0 +Prdx6 PRDX6 Amino Acid Metabolism - phenylalanine; EC 1.11.1.15; EC 1.11.1.9; Energy Metabolism - methane; Oxidoreductase; Phospholipase O08709 11758 1 H2.1|1 69.75 cM mouse T177-p 3823356 TGTKPVAtPVDWKKG 1-cysPrx_C activity, induced; intracellular localization 21262967 4 5 12 NOX2 activated +PRKDC DNAPK DNA repair, damage; EC 2.7.11.1; KINASE; Kinase, protein; Nucleolus; Protein kinase, Ser/Thr (non-receptor); Protein kinase, atypical P78527 5591 8q11.21 human T2638-p 448712 VAGQIRAtQQQHDFT DNAPKcs_CC5 molecular association, regulation; protein conformation DNA repair, induced; chromatin organization, altered; cell growth, altered DNA(DISRUPTS) 17189255; 24687855 6 13 8 increases survival in ionizing radiation and repairing double strand DNA breaks; cell survival induced, induces removal of cisplatin adducts from DNA, induces end processing +KCNA3 Kv1.3 Channel, potassium; Membrane protein, integral; Membrane protein, multi-pass P22001 3738 1p13.3 human Y187-p 451293 FSEEIRFyQLGEEAM BTB_2 activity, induced 11812778 1 0 0 +MASTL MASTL EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, AGC; Protein kinase, Ser/Thr (non-receptor) Q96GX5 84930 10p12.1 human T194-p 3209097 NMMDILTtPSMAKPR Pkinase activity, induced; intracellular localization cell cycle regulation 24391510 2 3 0 +TRAPPC6A TRAPPC6A O75865 79090 19q13.32 human S35-p 23155168 GGQKMSLsVLEGMGF TRAPP molecular association, regulation; intracellular localization; protein conformation apoptosis, induced TIAF1(INDUCES) 25650666; 27551439 2 0 1 Mutant proteins do not cause aggregation or caspase activation. ; protein aggregation, Ser35 phosphorylation is essential for relocation of TPC6A to the nucleolus and pTyr112 needed for relocation to the cytoplasm +DLG4 PSD-95 Adaptor/scaffold P78352 1742 17p13.1 human Y523-p 4093600 REDSVLSyETVTQME activity, induced; molecular association, regulation; phosphorylation neural plasticity; apoptosis, induced Pyk2(INDUCES) 22709448; 24981431 3 0 0 activation of NMDA receptor function, NR2A phosphorylation; neural excitotoxicity increased +Zbp1 ZBP1 DNA-binding; Motility/polarity/chemotaxis Q9QY24 58203 2|2 H3 mouse K17-ub 1873076610 TGDNLEQkILQVLSD z-alpha apoptosis, induced 28634194 1 1 0 induces apoptosis due to influenza A virus infection +PIAS1 PIAS1 EC 6.3.2.-; Nuclear receptor co-regulator; SUMO LIGASE; SUMO conjugating system; SUMO ligase; Transcription, coactivator/corepressor O75925 8554 15q23 human K238-sm 55435684 PGYLPPTkNGVEPKR PINIT intracellular localization 32047143 1 3 0 +SNX5 SNX5 Vesicle Q9Y5X3 27131 20p11.23 human S226-p 1296362401 YYNRIKDsCVKADKM Vps5 molecular association, regulation; intracellular localization; activity, inhibited endocytosis, induced SNX1(DISRUPTS); SNX2(DISRUPTS) 30419003 1 1 0 Phosphorylation of SNX5 inhibits both macropinocytosis and CI-M6PR retrograde transport. +PRMT8 PRMT8 EC 2.1.1.-; METHYLTRANSFERASE; Methyltransferase; Methyltransferase, protein arginine Q9NR22 56341 12p13.32 human R58-m1 2574937 TQPSCPGrGKMSKLL enzymatic activity, altered PRMT8(INDUCES) 17925405 1 1 0 automethylation +TPT1 TPT1 Calcium-binding; Microtubule-binding P13693 7178 13q14.13 human T65-p 34501092 EGEGTEStVITGVDI TCTP protein degradation carcinogenesis, inhibited; apoptosis, induced 34675258 1 2 0 +PECAM1 PECAM-1 Cell adhesion; Cell development/differentiation; Membrane protein, integral; Motility/polarity/chemotaxis P16284 5175 17q23.3 human S700-p 455609 VQVSSAEsHKDLGKK molecular association, regulation CTNNG(DISRUPTS) 15766557 1 1 2 +Braf BRAF iso1 EC 2.7.11.1; KINASE; Kinase, protein; Oncoprotein; Protein kinase, Ser/Thr (non-receptor); Protein kinase, TKL P28028-1 109880 6 B1|6 18.43 cM mouse S639-p 447805 FGLATVKsRWSGSHQ PK_Tyr_Ser-Thr activity, induced; phosphorylation carcinogenesis, induced; signaling pathway regulation 30659267 11 0 0 phosphorylation of MEK/ERK and its signaling +GLO1 GLO1 Carbohydrate Metabolism - pyruvate; EC 4.4.1.5; Lyase Q04760 2739 6p21.2 human Y136-p 463450 GIAVPDVySACKRFE Glyoxalase enzymatic activity, induced 34838714 1 0 19 +Slc14a2 SLC14A2 Membrane protein, integral; Membrane protein, multi-pass; Transporter; Transporter, SLC family Q62668 54302 18q12.3 rat T524-p 2813502 PYLYRKPtVELLDLN activity, induced 18495802 1 0 0 +CCAR2 DBC-1 Apoptosis; Mitochondrial; Nuclear receptor co-regulator; RNA-binding; Tumor suppressor Q8N163 57805 8p21.3 human T454-p 453498 AAEAAPPtQEAQGET DBC1 molecular association, regulation; activity, inhibited SIRT1(INDUCES) 25361978 3 7 38 inhibits SIRT1 +SLC9A1 NHE1 Membrane protein, integral; Membrane protein, multi-pass; Motility/polarity/chemotaxis; Transporter; Transporter, SLC family P19634 6548 1p36.11 human S693-p 468293 VPAHKLDsPTMSRAR NEXCaM_BD protein stabilization; protein conformation 28554535 2 56 161 +Jph2 JPH2 Contractile; Endoplasmic reticulum; Membrane protein, integral Q9ET78 59091 2|2 H2-H3 mouse S165-p 4779179 PLRTSLSsLRSEHSN molecular association, regulation TRPC3(INDUCES) 20095964 2 5 1 S165F mutant showes hypertrophy and increased resting cytoplasmic Ca2+ levels. +Hist1h2ail1 H3 DNA-binding Q6LED0 291159 17p11 rat S10-p 455676 TKQTARKsTGGKAPR Histone chromatin organization, altered; cytoskeletal reorganization; transcription, induced 17880897; 19940164 241 15 1 correlated with nuclear infolding +CLSPN claspin Actin-binding; Cell cycle regulation Q9HAW4 63967 1p34.3 human S34-p 467251 PSDSGQGsYETIGPL protein degradation; molecular association, regulation cell cycle regulation BTRC(INDUCES) 16885022 1 0 0 claspin degradation is necessary for termination of the DNA replication checkpoint. +FLCN FLCN Tumor suppressor Q8NFG4 201163 17p11.2 human S406-p 35542208 CVRIIPYsSQYEEAY Folliculin_C molecular association, regulation FNIP2(INDUCES); LC3B(DISRUPTS); GABARAP(DISRUPTS) 25126726 1 1 0 +Bcl2l1 Bcl-xL Apoptosis; Autophagy; Membrane protein, integral; Mitochondrial P53563 24888 3q41 rat S106-p 5014911 LRYRRAFsDLTSQLH Bcl-2 molecular association, regulation apoptosis, altered VDAC1(DISRUPTS); Akt1(INDUCES) 18951975 1 0 0 +Oprd1 DOR-1 GPCR, family 1; Membrane protein, integral; Membrane protein, multi-pass; Receptor, GPCR P32300 18386 4 D2.3|4 64.78 cM mouse S344-p 448552 CGRQEPGsLRRPRQA receptor desensitization, altered; receptor internalization, altered 11085981 1 0 0 +DLGAP1 SAPAP1 Cytoskeletal O14490 9229 18p11.31 human S375-p 481510 KVAARREsYLKATQP molecular association, regulation PSD-95(INDUCES) 22117215 2 1 0 Fluorescence Polarization +Sox9 SOX9 DNA-binding; Transcription factor Q04887 20682 11 E2|11 77.27 cM mouse R152-me 10338210 LLNESEKrPFVEEAE HMG_box molecular association, regulation cell cycle regulation; cell growth, induced; transcription, induced CTNNB1(DISRUPTS) 19725955 1 0 0 promotes cyclin D1 expression, regulates endochondral ossification, chondrocyte/cartilage development during embryogenesis +Cish CISH O70512 83681 8q32 rat K97-ub 37044800 EARQHLQkMPEGTFL SH2 protein degradation 25448846 1 0 0 +POLDIP3 SKAR RNA-binding Q9BY77 84271 22q13.2 human S385-p 454011 PRRVNSAsSSNPPAE activity, induced ERH(NOT_REPORTED) 15341740; 16984396 2 2 1 phosphorylation of this site is involved in the control of cell growth +Bcl2l11 BIM Apoptosis O54918 12125 2|2 F1 mouse S65-p 449330 GPLAPPAsPGPFATR protein degradation; molecular association, regulation apoptosis, altered; apoptosis, induced; apoptosis, inhibited BAX(DISRUPTS) 12818176; 15486085; 17105963; 18498746 23 1 1 +PRPF19 PRPF19 EC 6.3.2.-; EC 6.3.2.19; Ligase; RNA splicing; Spliceosome; UBIQUITIN LIGASE; Ubiquitin conjugating system; Ubiquitin ligase Q9UMS4 27339 11q12.2 human Y405-p 31823502 IAFSENGyYLATAAD WD40 molecular association, regulation; intracellular localization RFA2(INDUCES); H2AX(INDUCES) 24332808 1 0 0 +PIK3R1 PIK3R1 KINASE; Kinase, lipid; Motility/polarity/chemotaxis P27986 5295 5q13.1 human S608-p 448133 ENTEDQYsLVEDDED activity, induced 14729945 3 3 24 +IGF1R IGF1R EC 2.7.10.1; KINASE; Kinase, protein; Membrane protein, integral; Protein kinase, TK; Protein kinase, tyrosine (receptor) P08069 3480 15q26.3 human S1311-p 2091902 PLDPSASsSSLPLPD activity, induced; phosphorylation cell differentiation, altered; apoptosis, altered; cell growth, altered 10746631; 10786694 2 0 0 observed in Y980F + S1310-1313A; ERK phosphorylation +PARP1 PARP1 DNA repair, damage; EC 2.4.2.30; Nuclear envelope; Nuclear receptor co-regulator; Nucleolus; Transferase P09874 142 1q42.12 human K249-ac 12234031 NDLIWNIkDELKKVC protein degradation; ubiquitination 34555594; 35066290 2 1 3 +TOP1 TOP1 EC 5.99.1.2; Isomerase; Nucleolus; Oncoprotein P11387 7150 20q12 human S10-p 465604 GDHLHNDsQIEADFR protein degradation 28415827 3 31 0 +ACBD4 ACBD4 Lipid-binding Q8NC06 79777 17q21.31 human S169-p 34498308 PAPPSPEsHSPRDLD molecular association, regulation VAPB(INDUCES) 35019937 1 1 0 +Ror2 ROR2 EC 2.7.10.1; KINASE; Kinase, protein; Membrane protein, integral; Protein kinase, TK; Protein kinase, tyrosine (receptor) Q9Z138 26564 13 B1|13 27.68 cM mouse S864-p 20659200 PKPSSHHsGSGSTST cell motility, induced 21078818 1 0 0 +Dnm1l DRP1 Apoptosis; EC 3.6.5.5; Endoplasmic reticulum; Hydrolase; Microtubule-binding; Mitochondrial; Motor Q8K1M6 74006 16|16 A2 mouse S643-p 483971 VPVARKLsAREQRDC intracellular localization; activity, inhibited; phosphorylation transcription, induced; transcription, altered; signaling pathway regulation; autophagy, induced; cell growth, induced; apoptosis, inhibited; autophagy, inhibited; transcription, inhibited 28591721; 31326607; 33485986; 34433037; 34705256; 34940790; 35720196; 35791786; 35819738; 35860026; 36008706 103 3 0 +ZBTB1 ZBTB1 C2H2-type zinc finger protein Q9Y2K1 22890 14q23.3 human K265-sm 2894413 DGKDSNIkAEFGEKD activity, inhibited transcription, altered 20797634 1 3 0 reduces transcriptional repressive activity +Lrrc7 LRRC7 Cell adhesion P70587 117284 2q45 rat S1392-p 481330 IQTKGQRsMDGYPEQ molecular association, regulation CAMK2A(DISRUPTS) 11160423 1 10 0 +Lrp6 LRP6 Membrane protein, integral; Receptor, misc. O88572 16974 6 G1|6 65.37 cM mouse S1490-p 456289 AILNPPPsPATERSH intracellular localization cell differentiation, inhibited; carcinogenesis, induced; cell growth, induced; transcription, induced; signaling pathway regulation 24692544; 32139604; 33929542; 36103813 32 13 55 +RPTOR Raptor Adaptor/scaffold Q8N122 57521 17q25.3 human S859-p 2024885 DTSSLTQsAPASPTN molecular association, regulation signaling pathway regulation mTOR(INDUCES); 4E-BP1(DISRUPTS) 21460630; 26348909 5 70 5 mTORC1 signaling +Max MAX DNA-binding; Transcription factor P52164 60661 6q24 rat S2-p 449307 ______MsDNDDIEV molecular association, regulation DNA(NOT_REPORTED) 8247525 5 35 0 increases both the on- and off-rates for DNA binding +Pag1 PAG Adaptor/scaffold; Membrane protein, integral Q3U1F9 94212 3|3 A1 mouse Y314-p 450659 EEEISAMySSVNKPG PAG molecular association, regulation CSK(INDUCES) 17210649 9 31 643 +Carm1 CARM1 EC 2.1.1.125; METHYLTRANSFERASE; Methyltransferase; Methyltransferase, protein arginine; Nuclear receptor co-regulator Q9WVG6 59035 9|9 A3 mouse S217-p 11311202 KIYAVEAsTMAQHAE PrmA intracellular localization; enzymatic activity, inhibited 19843527 1 1 0 reduces cofactor AdoMet binding +KAT2A GCN5 ACETYLTRANSFERASE; Acetyltransferase; EC 2.3.1.48 Q92830 2648 17q21.2 human K549-ac 27421702 LVFDPKHkTLALIKD Acetyltransf_1 acetylation; enzymatic activity, induced transcription, altered 23142079 1 1 0 direct opposition to Sirt1; increases PGC-1a acetylation; Regulates the gluconeogenic transcriptional response of fasted mice +Axin1 axin 1 Adaptor/scaffold; Tumor suppressor O70239 79257 10q12 rat S485-p 451092 MRTPGCQsPGPGHRS Axin_b-cat_bind cytoskeletal reorganization 22933777 2 9 6 Phosphorylation regulates responsive to Sema3A induced growth cone collapse. +CUL5 CUL5 UBIQUITIN LIGASE; Ubiquitin conjugating system; Ubiquitin ligase Q93034 8065 11q22.3 human S730-p 963800 MKMRKKIsNAQLQTE Cullin_Nedd8 intracellular localization; activity, inhibited; neddylation; phosphorylation cell cycle regulation; cell growth, inhibited; cell growth, altered 10898738; 12917106; 19917606; 21635549 5 0 0 +FGFR1 FGFR1 EC 2.7.10.1; KINASE; Kinase, protein; Membrane protein, integral; Oncoprotein; Protein kinase, TK; Protein kinase, tyrosine (receptor) P11362 2260 8p11.23 human S779-p 27930809 PLDQYSPsFPDTRSS cell differentiation, induced; apoptosis, inhibited 23564461 1 0 0 neurite extension +SQSTM1 SQSTM1 Autophagy; Nuclear receptor co-regulator; Ubiquitin conjugating system Q13501 8878 5q35.3 human S403-p 22264800 ESLSQMLsMGFSDEG UBA_5 activity, induced; protein degradation; molecular association, regulation; ubiquitination; intracellular localization; phosphorylation autophagy, induced; cell growth, induced; cell differentiation, induced; transcription, induced; autophagy, inhibited; signaling pathway regulation ubiquitin(INDUCES); KEAP1(INDUCES) 22017874; 22921120; 25505069; 27846364; 29147513; 31444413; 32835772; 34226595; 34903812; 36284367; 37306101 30 7 0 +SLC4A1 SLC4A1 Membrane protein, integral; Membrane protein, multi-pass; Transporter; Transporter, SLC family P02730 6521 17q21.31 human Y904-p 455304 EEEGRDEyDEVAMPV intracellular localization 15649129 8 4 36 +Map2 MAP2 iso3 Cytoskeletal; Motility/polarity/chemotaxis P15146-3 25595 9q32 rat K292-ac 62495500 AIIRTPPkSPATPKQ cytoskeletal reorganization 28002468 1 1 0 +GRIN2A NMDAR2A Channel, ligand-gated; Membrane protein, integral; Membrane protein, multi-pass Q12879 2903 16p13.2 human Y1325-p 458211 RLLEGNFyGSLFSVP NMDAR2_C activity, induced 19834457 8 2 84 +Ezr Ezrin Cytoskeletal; Motility/polarity/chemotaxis P26040 22350 17|17 A1 mouse Y146-p 448758 KEMHKSGyLSSERLI FERM_M intracellular localization; phosphorylation cell cycle regulation; apoptosis, inhibited; cell growth, altered 18182570; 24385580 16 2 2 localization at the plasma membrane; ERK phosphorylation +Prkg2 PKG2 EC 2.7.11.12; KINASE; Kinase, protein; Protein kinase, AGC; Protein kinase, Ser/Thr (non-receptor) Q61410 19092 5 E3|5 48.35 cM mouse S126-p 450477 RGAKAGVsAEPTTRT enzymatic activity, induced transcription, induced; signaling pathway regulation 12764134; 21131365 2 1 0 induces NFAT signaling +DNAJB1 HSP40 Chaperone; Nucleolus P25685 3337 19p13.12 human S171-p 30306602 VTHDLRVsLEEIYSG DnaJ_C transcription, inhibited 24309468 1 2 0 +Lipe HSL EC 3.1.1.79; Lipase P15304 25330 1q21 rat S865-p 448804 ESMRRSVsEAALAQP enzymatic activity, induced 9636039 27 28 1 +SMN1 SMN RNA processing; RNA-binding Q16637 6606 5q13.2 human S88-p 5498504 QKKNTAAsLQQWKVG SMN molecular association, regulation; intracellular localization coilin(INDUCES) 24602413 1 2 2 +VAV3 VAV3 Actin-binding; Adaptor/scaffold; GEF; GEF, Rac/Rho; Motility/polarity/chemotaxis; Nuclear receptor co-regulator Q9UKW4 10451 1p13.3 human Y164-p 1869344402 EDLYDCVyGEDEGGE activity, induced 32561640 1 0 0 VAV3 signaling activity +Cebpb C/EBP-beta DNA-binding; Motility/polarity/chemotaxis; Transcription factor P28033 12608 2 H3|2 87.58 cM mouse K215-ac 458939 APAKAKAkKTVDKLS molecular association, regulation transcription, inhibited DNA(DISRUPTS) 22865229 4 0 0 +YY1 YY1 C2H2-type zinc finger protein; Cell development/differentiation; Transcription factor P25490 7528 14q32.2 human S118-p 460025 EVVGGDDsDGLRAED protein stabilization 22184066 3 34 0 prevention of phosphorylation at this site enhances YY1 cleavage by caspase 7 during apoptosis +ZXDC ZXDC C2H2-type zinc finger protein Q2QGD7 79364 3q21.3 human K660-sm 2890300 PELLAPIkVEPDSPS transcription, induced 17696781 1 1 0 +E2F3 E2F3 Cell cycle regulation; DNA-binding; Transcription factor O00716 1871 6p22.3 human S124-p 11929101 PALGRGGsGGGGGPP protein stabilization DNA repair, induced; transcription, induced 26921499 2 0 0 +Ar AR DNA-binding; Nuclear receptor; Transcription factor P19091 11835 X C3|X 42.82 cM mouse Y531-p 1243001 DHVLPIDyYFPPQKT intracellular localization cell cycle regulation; carcinogenesis, induced; cell motility, induced; cell growth, induced; transcription, induced 35595729 1 1 0 +Kcnc3 Kv3.3 Membrane protein, integral; Membrane protein, multi-pass Q63959 16504 7 B3|7 28.85 cM mouse S9-p 2840510 LSSVCVWsFRGRQGT Potassium_chann activity, inhibited 18539595 1 0 0 +Gabbr1 GABBR1 GPCR, family 3; Membrane protein, integral; Membrane protein, multi-pass; Receptor, GPCR Q9Z0U4 81657 20p12 rat K697-ub 59175201 VFTKKEEkKEWRKTL 7tm_3 receptor recycling, inhibited; protein degradation; intracellular localization 27573246 1 0 0 +NR3C2 MCR DNA-binding; Nuclear receptor P08235 4306 4q31.23 human T800-p 1875398904 LPLEDQItLIQYSWM Hormone_recep molecular association, regulation; intracellular localization transcription, induced DNA(INDUCES) 34847273 1 0 0 +Grap2 GADS Adaptor/scaffold O89100 17444 15|15 E1 mouse T254-p 451895 TLMHRRHtDPVQLQA molecular association, regulation 14-3-3 zeta(INDUCES) 22105350 2 16 142 phosphorylation causes a disruption of microclusters and prevents T cell activation +PDCD6IP Alix Adaptor/scaffold; Apoptosis Q8WUM4 10015 3p22.3 human Y319-p 457636 KKDNDFIyHDRVPDL BRO1 molecular association, regulation; protein conformation cell adhesion, altered Pyk2(INDUCES); Src iso1(INDUCES); Alix(DISRUPTS); FAK(INDUCES) 12771190; 15557335; 34688656 3 4 88 +PDE6G PDE6G EC 3.1.4.35; Nucleotide Metabolism - purine; Phosphodiesterase P04972 281977 cow T35-p 450149 PKFKQRQtRQFKSKP PDE6_gamma phosphorylation 19878658 5 0 0 phosphorylation of T22 is attenuated in PDE6G T35A mutant +CCR7 CCR7 GPCR, family 1; Membrane protein, integral; Membrane protein, multi-pass; Motility/polarity/chemotaxis; Receptor, GPCR P32248 1236 17q21.2 human Y155-p 53340200 LCISIDRyVAIVQAV 7tm_1 molecular association, regulation cell motility, induced; signaling pathway regulation SHP-2(INDUCES); RAC1(INDUCES); VAV1(INDUCES) 26789922; 31644919 2 0 0 T cell migration toward CCL21; phosphorylation induces interaction with VAV1, further enhancing Rac1 recruitment and regulating CCR7 signaling complex +BCL2L11 BIM iso2 Apoptosis O43521-2 10018 2q13 human T56-p 449071 SCDKSTQtPSPPCQA activity, induced; molecular association, regulation apoptosis, induced LC8(DISRUPTS) 12591950 10 1 0 +Stat6 STAT6 DNA-binding; Transcription factor P52633 20852 10 D3|10 74.59 cM mouse T645-p 451417 GRGYVSTtIKMTVER apoptosis, inhibited; cell motility, inhibited; transcription, inhibited 33934104 1 1 1 reduce TNF alpha production and tubular cell death +Esrrg ERR3 DNA-binding; Nuclear receptor; Transcription factor P62509 26381 1|1 H5-H6 mouse S179-p 36400701 ITKRRRKsCQACRFM zf-C4 intracellular localization transcription, inhibited 25205222 1 0 0 inhibits hepatic gluconeogenesis +ARHGAP5 ARHGAP5 GAP; GAP, Rac/Rho; Motility/polarity/chemotaxis Q13017 394 14q12 human Y306-p 449920 NHPDYEEyINLEGTR RhoGAP-FF1 intracellular localization cell differentiation, altered 12705864 1 0 0 +FANCD2 FANCD2 DNA repair, damage Q9BXW9 2177 3p25.3 human S891-p 1871613601 TLSEEKNsECDPTPS FancD2 molecular association, regulation; ubiquitination; intracellular localization; activity, inhibited cell cycle regulation; DNA repair, inhibited; signaling pathway regulation DNA(DISRUPTS) 31167143 1 1 0 inhibits Fanconi anemia pathway leading to inhibition of DNA repair; 882-898 cluster +IKBKG IKKG Adaptor/scaffold; Protein kinase, regulatory subunit Q9Y6K9 8517 Xq28 human K277-ub 486354 AEEALVAkQEVIDKL CC2-LZ activity, inhibited transcription, induced; transcription, inhibited 14651848; 19223549; 28490597 3 2 0 regulates activation of NF-kB +Itgb2 ITGB2 Cell adhesion; Cell surface; Membrane protein, integral; Motility/polarity/chemotaxis; Receptor, misc. P11835 16414 10 C1|10 39.72 cM mouse T761-p 448535 PLFKSATtTVMNPKF Integrin_b_cyt cell motility, induced; cell adhesion, induced 23823319 2 0 0 T-cell homing to lymphocytes +Nlrp3 NLRP3 Inhibitor Q8R4B8 216799 11|11 B1.3 mouse S725-p 31904665 VNCCLTSsFCRGLFS activity, induced; molecular association, regulation NLRP3(INDUCES) 34480147 3 4 0 +KLF10 KLF10 C2H2-type zinc finger protein; DNA-binding; Transcription factor Q13118 7071 8q22.3 human T93-p 23119614 TIPAFCLtPPYSPSD protein degradation; molecular association, regulation PIN1(INDUCES) 23994618 1 0 1 +TET2 TET2 EC 1.14.11.n2; Oxidoreductase; Tumor suppressor Q6N021 54790 4q24 human K111-ac 63106403 SGLLQIKkLKQDQKA protein stabilization; molecular association, regulation; ubiquitination; methylation; enzymatic activity, induced DNA repair, induced DNMT1(INDUCES) DNA(INDUCES) 28107650 1 1 0 inhibits ubiquitination, protects against abnormal DNA methylation +FOSL2 FRA2 DNA-binding; Transcription factor P15408 2355 2p23.2 human S320-p 4707550 QSSDSLNsPTLLAL_ methylation cell differentiation, induced; transcription, induced 25547114 2 14 11 +HTRA2 HTRA2 EC 3.4.21.108; Membrane protein, integral; Mitochondrial; Protease O43464 27429 2p13.1 human S212-p 477180 RVRVRLLsGDTYEAV Peptidase_M50; Trypsin_2 intracellular localization; enzymatic activity, inhibited apoptosis, induced 17311912 1 0 2 +NDEL1 NDEL1 Microtubule-binding; Protease Q9GZM8 81565 17p13.1 human T245-p 3211851 GFGTSPLtPSARISA NUDE_C molecular association, regulation; intracellular localization PAFAH1B1(INDUCES) 12556484 2 7 3 +AHSG FETUA Secreted; Secreted, signal peptide P02765 197 3q27.3 human S328-p 467424 MGVVSLGsPSGEVSH signaling pathway regulation 35522655 2 20 22 repair insulin signaling +Ctnnb1 CTNNB1 Actin-binding; Cell adhesion; Motility/polarity/chemotaxis; Nuclear receptor co-regulator; Oncoprotein; Transcription factor Q9WU82 84353 8q32 rat S552-p 472273 QDTQRRTsMGGTQQQ protein stabilization; intracellular localization cell cycle regulation; autophagy, induced; cell growth, induced 33518533 44 64 9 +Abi1 Abi-1 Adaptor/scaffold; Motility/polarity/chemotaxis Q8CBW3 11308 2 A3|2 15.18 cM mouse S88-p 27115701 SQLRRMEsSINHISQ cytoskeletal reorganization 22993434 1 1 0 Rac activation and spine maturation +ZC3HC1 NIPA Cell cycle regulation; Ubiquitin conjugating system Q86WB0 51530 7q32.2 human S338-p 468305 DATFSPGsEQAEKSP Rsm1 molecular association, regulation; intracellular localization cell growth, induced NPM-ALK(DISRUPTS) 31434245 1 29 2 +Map2 MAP2 iso3 Cytoskeletal; Motility/polarity/chemotaxis P15146-3 25595 9q32 rat K379-ac 62495507 FKEKAQAkVGSLDNA Tubulin-binding cytoskeletal reorganization 28002468 1 1 0 +INPP5D SHIP EC 3.1.3.86; Motility/polarity/chemotaxis; Phosphatase, lipid Q92835 3635 2q37.1 human S27-p 15621800 SRTGKDGsFLVRASE SH2 protein degradation carcinogenesis, induced; cell growth, induced 31377397 2 2 0 +Ctnnb1 CTNNB1 Actin-binding; Cell adhesion; Motility/polarity/chemotaxis; Nuclear receptor co-regulator; Oncoprotein; Transcription factor Q9WU82 84353 8q32 rat S37-p 447582 YLDSGIHsGATTTAP protein degradation 14985333 110 3 12 +PDPK1 PDK1 EC 2.7.11.1; KINASE; Kinase, protein; Nuclear receptor co-regulator; Protein kinase, AGC; Protein kinase, Ser/Thr (non-receptor) O15530 5170 16p13.3 human Y9-p 447696 ARTTSQLyDAVPIQS protein degradation; molecular association, regulation; phosphorylation; enzymatic activity, induced transcription, altered HSP90A(INDUCES); Src(INDUCES) 12738763; 18024423 5 1 6 phosphorylation of PDK1 Y373/376; inhibits p53 promoter transcription +PIN1 PIN1 EC 5.2.1.8; Isomerase; Nuclear receptor co-regulator Q13526 5300 19p13.2 human S65-p 456481 SHLLVKHsQSRRPSS Rotamase protein stabilization 16118204 1 1 0 +LIMK1 LIMK1 EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, Ser/Thr (non-receptor); Protein kinase, TKL P53667 3984 7q11.23 human S323-p 459630 KDLGRSEsLRVVCRP enzymatic activity, induced cell motility, altered 16456544 1 3 0 important for VEGF-induced stress fiber formation +Pdxk PDXK Cofactor and Vitamin Metabolism - vitamin B6; EC 2.7.1.35; Kinase, other O35331 83578 20p12 rat S285-p 3403601 AGEGQKPsPAQLELR Phos_pyr_kin enzymatic activity, induced 35050500 0 8 0 +MYH7 MYH7 Motility/polarity/chemotaxis; Motor P12883 4625 14q11.2 human K58-ac 36295041 IVSREGGkVTAETEY Myosin_N molecular association, regulation; protein conformation 35502901 0 2 0 +EZH2 EZH2 EC 2.1.1.43; METHYLTRANSFERASE; Methyltransferase; Methyltransferase, protein lysine Q15910 2146 7q36.1 human S220-p 25291187 RPPRKFPsDKIFEAI PRC2_HTH_1 protein stabilization; molecular association, regulation; ubiquitination USP36(INDUCES) 31434700 1 1 1 deubiquitination/inhibit ubiquitination +SLK SLK EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, STE; Protein kinase, Ser/Thr (non-receptor) Q9H2G2 9748 10q24.33-q25.1 human T193-p 1211370 RRDSFIGtPYWMAPE Pkinase enzymatic activity, induced 28475647 1 9 58 +Vav1 VAV1 GEF; GEF, Rac/Rho; Motility/polarity/chemotaxis; Oncoprotein P27870 22324 17 D|17 29.76 cM mouse Y142-p 448809 ALNDEDIySGLSDQI molecular association, regulation; protein conformation; activity, inhibited; phosphorylation cytoskeletal reorganization; transcription, altered; cell growth, altered VAV1(INDUCES) 10669745; 20141838 6 2 0 +ABRAXAS1 Abraxas DNA repair, damage Q6UWZ7 84142 4q21.23 human S406-p 3203163 GFGEYSRsPTF____ molecular association, regulation DNA repair, induced BRCA1(INDUCES) 17525340 2 25 13 Abraxas and RAP80 form a complex that interacts with BRCA1. +Hmgcr HMGCR EC 1.1.1.34; Endoplasmic reticulum; Membrane protein, integral; Membrane protein, multi-pass; Motility/polarity/chemotaxis; Oxidoreductase; Secondary Metabolites Metabolism - terpenoid backbone biosynthesis Q01237 15357 13 D1|13 50.65 cM mouse K248-ub 10844794 VLEEEENkPNPVTQR protein degradation 27129778 3 8 25 +NOX4 NOX4 Cell cycle regulation; EC 1.6.3.-; Membrane protein, integral; Membrane protein, multi-pass; Nucleolus; Oxidoreductase Q9NPH5 50507 11q14.3 human Y491-p 27930805 WQENRPDyVNIQLYL NAD_binding_6 molecular association, regulation cell growth, induced GRB2(INDUCES); SHPS1(INDUCES) 23612968 1 0 0 mediated by Grb2; Grb2 recruitment to SHPS1 +CD3E CD3E Membrane protein, integral; Receptor, misc. P07766 916 11q23.3 human Y188-p 448918 PPVPNPDyEPIRKGQ ITAM molecular association, regulation; phosphorylation NCK2(DISRUPTS); EPS8(DISRUPTS); NCK1(DISRUPTS) 17617578; 18555270; 32317279 5 12 382 +EEF2K EEF2K EC 2.7.11.20; KINASE; Kinase, protein; Protein kinase, Ser/Thr (non-receptor); Protein kinase, atypical; Translation O00418 29904 16p12.2 human S74-p 3150899 ERYSSSGsPANSFHF enzymatic activity, inhibited carcinogenesis, induced; cell growth, induced; translation, induced 35513296 1 29 2 +ITGB4 ITGB4 Cell adhesion; Membrane protein, integral; Motility/polarity/chemotaxis; Receptor, misc. P16144 3691 17q25.1 human Y1564-p 456323 LQGYSVEyQLLNGGE fn3 intracellular localization apoptosis, induced; transcription, induced 23677256 6 0 1 Induce mRNA and protein levels of IL-8, PTGS2, KITLG and ATF3 +GAPDH GAPDH Carbohydrate Metabolism - glycolysis and gluconeogenesis; EC 1.2.1.12; Oxidoreductase P04406 2597 12p13.31 human S122-p 31881707 GAKRVIIsAPSADAP activity, induced; intracellular localization autophagy, induced 26626483 2 4 0 +Ciz1 CIZ1 Cell cycle regulation Q8VEH2 68379 2|2 B mouse T144-p 23094081 LTPPQMVtPNLQQFF molecular association, regulation; activity, inhibited cell cycle regulation CCNA1(DISRUPTS) 25736292 1 0 1 phosphorylation of T293 and T192, T144 are required for interaction with the cyclinA-CDK2 complex and directing it to chromatin +DVL2 DVL2 Adaptor/scaffold; Motility/polarity/chemotaxis O14641 1856 17p13.1 human S597-p 22682200 RSSGSTRsDGGAGRT Dsh_C cytoskeletal reorganization; transcription, inhibited 23396967 2 0 0 neurite outgrowth +Kcnb1 Kv2.1 Channel, cation; Channel, ligand-gated; Channel, potassium; Membrane protein, integral; Membrane protein, multi-pass Q03717 16500 2 H3|2 87.22 cM mouse Y814-p 22874700 FLRPNCVyASEGLPG phosphorylation 33333928 2 1 1 affects the phosphorylation of the site S804 +PANX1 PANX1 Cell adhesion; Membrane protein, integral; Membrane protein, multi-pass Q96RD7 24145 11q21 human Y199-p 462886 KYPIVEQyLKTKKNS Innexin activity, induced; intracellular localization 30814251 2 0 2 induces vasoconstriction +LAX1 LAX1 Adaptor/scaffold; Membrane protein, integral Q8IWV1 54900 1q32.1 human Y268-p 35546002 SSQISNDyVNMTGLD LAX molecular association, regulation transcription, inhibited; signaling pathway regulation GRB2(INDUCES); GADS(INDUCES); PIK3R1(INDUCES) 12359715 1 0 0 +APEX1 APE1 DNA repair, damage; DNA-binding; Deoxyribonuclease; EC 4.2.99.18; Endoplasmic reticulum; Hydrolase; Lyase; Nuclear receptor co-regulator; Nucleolus; Transcription, coactivator/corepressor P27695 328 14q11.2 human K27-ac 15207802 EPEAKKSkTAAKKND acetylation; molecular association, regulation; intracellular localization; protein conformation; enzymatic activity, induced DNA repair, induced; cell growth, induced; cell growth, inhibited NPM1(DISRUPTS); XRCC1(INDUCES) RNA(DISRUPTS) 20699270; 22918947; 27994014 4 2 0 +Eif4ebp1 4E-BP1 Translation; Translation initiation Q62622 116636 16q12.3 rat T45-p 447496 GGTLFSTtPGGTRII eIF_4EBP molecular association, regulation; phosphorylation translation, altered EIF4E(DISRUPTS) 10779345; 20736160; 9806882 156 36 91 +SCN5A SCN5A Channel, sodium; Membrane protein, integral; Membrane protein, multi-pass Q14524 6331 3p22.2 human K1479-ac 63044906 NFNQQKKkLGGQDIF Ion_trans intracellular localization; activity, inhibited 28191886; 32209328 3 2 0 NR decreased current in K1479A SCN5A, but increased INa. Disruption of S1503 site abolished effect on INa.; NR increased current, INa +Neurog2 neurogenin 2 Transcription factor P70447 11924 3|3 G2 mouse S231-p 2255101 SPYSCTLsPASPGSD molecular association, regulation cell growth, altered LDB1(INDUCES) 18400164 2 0 0 important for spinal motor neuron differentiation +RUNX3 AML2 DNA-binding; Transcription factor Q13761 864 1p36.11 human S149-p 6097701 GRSGRGKsFTLTITV Runt protein stabilization; intracellular localization cell cycle regulation; transcription, altered 18767071 1 1 1 +Fto FTO DEMETHYLASE; Demethylase; EC 1.14.11.- Q8BGW1 26383 8 C4-C5|8 44.34 cM mouse S253-p 27449492 CEGSEDEsEDESSFE FTO_NTD protein degradation; ubiquitination 29777057 1 7 0 +SEC23A SEC23A Motility/polarity/chemotaxis Q15436 10484 14q21.1 human S207-p 89117912 LQEMLGLsKVPLTQA Sec23_trunk molecular association, regulation SEC31A(DISRUPTS) 28486929 1 0 0 +Opn4 melanopsin GPCR, family 1; Membrane protein, integral; Membrane protein, multi-pass; Receptor, GPCR Q9QXZ9 30044 14|14 B mouse S395-p 1868515101 STLSSQSsDLSWISG molecular association, regulation; protein conformation ARRB1(INDUCES) 32236094 1 1 0 +P2rx1 P2X1 Channel, ligand-gated; Membrane protein, integral; Membrane protein, multi-pass P51576 18436 11 B4|11 45.09 cM mouse T389-p 26392106 DPAATSStLGLQENM carcinogenesis, induced; cell growth, induced 36418376 2 1 0 +LAT LAT iso2 Adaptor/scaffold; Membrane protein, integral O43561-2 27040 16p11.2 human K204-ub 56394100 ELHPGAAkTEPAALS LAT protein degradation; ubiquitination 27221712 1 0 0 Y132 phosphorylation is required for ubiquitylation. +Slc9a1 NHE1 Membrane protein, integral; Membrane protein, multi-pass; Motility/polarity/chemotaxis; Transporter; Transporter, SLC family P26431 24782 5q36 rat Y561-p 1872043502 LNRFNKKyVKKCLIA activity, inhibited 33585583 1 1 0 +AKAP8 AKAP8 Adaptor/scaffold; Cell cycle regulation; Mitochondrial; RNA-binding O43823 10270 19p13.12 human Y51-p 40420005 SVTTGATySYGPASW molecular association, regulation 25770215 1 0 0 Phenylalanine mutants inhibited dissociation from nuclear structures; structural chromatin changes +ADRB2 ADRB2 GPCR, family 1; Membrane protein, integral; Membrane protein, multi-pass; Receptor, GPCR P07550 154 5q32 human S355-p 458916 KAYGNGYsSNGNTGE receptor internalization, induced; protein degradation; molecular association, regulation; receptor desensitization, altered; intracellular localization; receptor internalization, altered; protein conformation cell motility, induced; signaling pathway regulation ARR3(INDUCES); ARRB2(INDUCES) 11040066; 16407241; 16980556; 18801735; 20193676; 20345371; 21868357; 22275358; 25395624; 31088898 27 2 0 B-arrestin recruitment; B-arrestin mediated signaling +MACROH2A1 H2AFY iso1 DNA-binding O75367-1 9555 5q31.1 human K12-ub 1877384700 GGKKKSTkTSRSAKA Histone intracellular localization DNA repair, induced 32424115 1 0 0 recruiting downstream DNA repair proteins to DNA breaks +DIAPH2 Diaphanous-2 iso4 Cytoskeletal; Motility/polarity/chemotaxis Q17R91 1730 Xq21.33 human T66-p 11147321 ITSFRKStVKKEKPL cell cycle regulation; chromatin organization, altered; cytoskeletal reorganization 21397845 1 0 0 mutation of this site disrupts metaphase chromosome alignment +SUV39H1 SUV39H1 Amino Acid Metabolism - lysine degradation; EC 2.1.1.43; METHYLTRANSFERASE; Methyltransferase; Methyltransferase, protein lysine O43463 6839 Xp11.23 human Y297-p 1867984203 YDRQGATyLFDLDYV SET methylation; enzymatic activity, induced signaling pathway regulation 30833073 1 0 0 NRG-1/ErbB4 signaling +CSNK2B CK2B KINASE; Protein kinase, regulatory subunit P67870 1460 6p21.33 human S4-p 455683 ____MSSsEEVSWIS protein stabilization 12032843 1 9 0 +RACK1 RACK1 Adaptor/scaffold; G protein; G protein, heterotrimeric; G protein, heterotrimeric beta; Motility/polarity/chemotaxis; Nuclear receptor co-regulator P63244 10399 5q35.3 human T50-p 23136904 WKLTRDEtNYGIPQR molecular association, regulation; protein conformation autophagy, induced; transcription, inhibited IRF3(INDUCES); beclin 1(INDUCES); PIK3R4(INDUCES); PIK3C3(INDUCES); IRF7(INDUCES) 26549445; 34348973 3 2 9 induces binding to IRF3/IRF7 thus inhibiting their phosphorylation +C3AR1 C3aR GPCR, family 1; Membrane protein, integral; Membrane protein, multi-pass; Receptor, GPCR Q16581 719 12p13.31 human T463-p 17552878 AAFSEELtRSTHCPS receptor desensitization, induced; molecular association, regulation transcription, inhibited ARRB2(INDUCES) 23077507 1 3 0 +NFATC1 NFAT2 DNA-binding; Transcription factor O95644 4772 18q23 human Y371-p 27427900 ADFAPEDySSFQHIR activity, induced; intracellular localization 23263556 2 1 0 +Opn4 melanopsin GPCR, family 1; Membrane protein, integral; Membrane protein, multi-pass; Receptor, GPCR Q8R456 192223 16p15 rat S381-p 36745800 QRSHPSLsYRSTHRS activity, induced 25378407 3 1 0 increases Ca2+ response +TGFBR2 TGFBR2 EC 2.7.11.30; KINASE; Kinase, protein; Membrane protein, integral; Oncoprotein; Protein kinase, Ser/Thr (receptor); Protein kinase, TKL P37173 7048 3p24.1 human Y424-p 2869602 GQVGTARyMAPEVLE PK_Tyr_Ser-Thr enzymatic activity, induced transcription, altered 9169454 3 0 9 +RBBP8 CtIP EC 3.1.-.-; Transcription, coactivator/corepressor Q99708 5932 18q11.2 human K896-sm 1873173300 SPKGKEQkT______ molecular association, regulation DNA repair, induced DNA(INDUCES) 28740167 1 0 0 +SELL SELL Membrane protein, integral P14151 6402 1q24.2 human S364-p 40548101 RLKKGKKsKRSMNDP molecular association, regulation Calmodulin(DISRUPTS) 25775539 2 0 0 +Ulk1 ULK1 Autophagy; EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, Other; Protein kinase, Ser/Thr (non-receptor) O70405 22241 5|5 F mouse S629-p 27460648 SPTKAGPsFDFPKTP cell cycle regulation; autophagy, induced; cell growth, induced 32516310 1 2 0 +KRT8 K8 Cytoskeletal P05787 3856 12q13.13 human K285-sm 25027600 AESMYQIkYEELQSL Filament cytoskeletal reorganization 21062750 1 3 0 sumoylation regulate solubility; modified by poly-SUMO-2/3 chains, oxidative stress, apoptosis, and/or phosphatase inhibition increase sumoylation in primary hepatocytes; K to R mutants show filament disorganization +XIAP XIAP Apoptosis; EC 6.3.2.-; Ligase; UBIQUITIN LIGASE; Ubiquitin conjugating system; Ubiquitin ligase P98170 331 Xq25 human S87-p 450336 VGRHRKVsPNCRFIN BIR activity, induced; molecular association, regulation; protein stabilization; enzymatic activity, induced carcinogenesis, induced; apoptosis, altered; cell growth, induced; apoptosis, inhibited; autophagy, inhibited; signaling pathway regulation MDM2(INDUCES) 14645242; 17537996; 23749209; 26314849; 30867140; 31493422; 31842909; 32050753 10 0 0 +Pitpna PITPNA Lipid-binding P53810 18738 11 B5|11 45.92 cM mouse S166-p 450933 EDPAKFKsVKTGRGP IP_trans intracellular localization 10801835 2 0 0 Stimulation of NIH3T3 fibroblasts by PMA or PDGF induced the rapid relocalization of PI-TPalpha to perinuclear Golgi structures. +Myd88 MYD88 Adaptor/scaffold P22366 17874 9 F3|9 71.33 cM mouse Y58-p 1876167500 AEEMGFEyLEIRELE Death transcription, induced 35003083 1 0 0 +PRKG1 PKG1 iso2 EC 2.7.11.12; KINASE; Kinase, protein; Protein kinase, AGC; Protein kinase, Ser/Thr (non-receptor) Q13976-2 5592 10q11.23-q21.1 human S81-p 452147 RTKRQAIsAEPTAFD enzymatic activity, induced 12080049 4 0 0 +Crmp1 CRMP-1 Cell development/differentiation; Cytoskeletal; Hydrolase P97427 12933 5 B3|5 19.96 cM mouse T509-p 454314 PVYEVPAtPKHAAPA phosphorylation 29758318 6 18 7 S522A KI mice +PDE4D PDE4D iso6 EC 3.1.4.53; Nucleotide Metabolism - purine; Phosphodiesterase Q08499-6 5144 5q11.2-q12.1 human K48-ub 7388021 EKSKTARkSVSPKLS molecular association, regulation RACK1(DISRUPTS); ARRB1(INDUCES) 19372219 1 0 0 +GTF2A1 GTF2A1 Transcription, coactivator/corepressor P52655 2957 14q31.1 human S321-p 448630 LNSEDDVsDEEGQEL TFIIA transcription, induced 11278496 1 5 2 +ATF4 ATF-4 DNA-binding; Transcription factor P18848 468 22q13.1 human R239-m2 1879738500 PQHSPSTrGSPNRSL protein stabilization 31787756 1 0 0 suppression of ER stress and cell death induced by tunicamycin treatment +SIAH2 SIAH2 EC 6.3.2.-; EC 6.3.2.19; Ligase; Transcription, coactivator/corepressor; UBIQUITIN LIGASE; Ubiquitin conjugating system; Ubiquitin ligase O43255 6478 3q25.1 human T26-p 5393503 PPPQPQHtPSPAAPP protein degradation; molecular association, regulation; intracellular localization; enzymatic activity, induced cytoskeletal reorganization HIPK2(DISRUPTS) 19043406; 22878263; 23044042; 26751770 5 2 0 +MAP1LC3C LC3C Autophagy; Microtubule-binding; Ubiquitin-like modifier; Vesicle Q9BXW4 440738 1q43 human S96-p 1869546301 VNNKSLVsMSATMAE ATG8 molecular association, regulation apoptosis, induced ATG4B(DISRUPTS) 31709703 1 1 0 ; including ATG4A, ATG4C, ATG4D +SP7 osterix C2H2-type zinc finger protein; DNA-binding; Transcription factor Q8TDD2 121340 12q13.13 human K58-ub 31914106 GSDLSASkTMGDAYP protein degradation cell differentiation, inhibited; transcription, inhibited 23457570 2 0 0 +EEF1A1 EEF1A1 Nucleolus; Translation; Translation elongation P68104 1915 6q13 human S300-p 15629200 EMHHEALsEALPGDN GTP_EFTU_D2 molecular association, regulation cell cycle regulation; translation, altered; carcinogenesis, altered; cell growth, altered RNA(NOT_REPORTED) 20832312 1 5 0 inhibits aa-tRNA binding by eEF1A-1 +Creb1 CREB DNA-binding; Transcription factor Q01147 12912 1 C2|1 32.74 cM mouse S107-p 451811 SVDSVTDsQKRREIL pKID intracellular localization 17244605 12 0 0 Preferentially localized to the soluble nucleoplasmic fraction. +DTL RAMP Adaptor/scaffold; DNA repair, damage; DNA replication; UBIQUITIN LIGASE; Ubiquitin conjugating system; Ubiquitin ligase Q9NZJ0 51514 1q32.3 human T464-p 4717290 DLPLPSNtPTFSIKT protein stabilization; molecular association, regulation; ubiquitination cell cycle regulation; cell differentiation, induced 14-3-3 epsilon(INDUCES); FBXO11(DISRUPTS); 14-3-3 gamma(INDUCES) 23478441; 25154416 2 0 2 prevention from polyubiquitination; inhibits ubiquitination +EEF2K EEF2K EC 2.7.11.20; KINASE; Kinase, protein; Protein kinase, Ser/Thr (non-receptor); Protein kinase, atypical; Translation O00418 29904 16p12.2 human S359-p 447826 GTEEKCGsPQVRTLS enzymatic activity, inhibited 11500363; 18337751 6 3 6 +THRA TR-alpha iso2 DNA-binding; Nuclear receptor; Transcription factor P10827-2 7067 17q21.1 human K288-sm 38557703 AVKREQLkNGGLGVV Hormone_recep cell growth, induced; cell differentiation, induced; transcription, induced; signaling pathway regulation 25572392 2 0 0 induces Wnt/?-catenin signaling pathway +HIPK2 HIPK2 EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, CMGC; Protein kinase, Ser/Thr (non-receptor) Q9H2X6 28996 7q34 human S359-p 12119325 HVSKAVCsTYLQSRY Pkinase molecular association, regulation; enzymatic activity, induced apoptosis, induced; signaling pathway regulation ASK1(INDUCES); JNK2(INDUCES) 27321923 1 4 22 HIPK2 and JNK activation +Pgam2 PGAM2 Carbohydrate Metabolism - glycolysis and gluconeogenesis; EC 3.1.3.13; EC 5.4.2.11; EC 5.4.2.4; Isomerase; Phosphatase (non-protein) O70250 56012 11|11 A1 mouse S118-p 4698936 QVKIWRRsFDTPPPP His_Phos_1 protein degradation; molecular association, regulation; ubiquitination MDM2(INDUCES) 24567357 1 5 0 +KIFC1 KIFC1 Microtubule-binding; Motility/polarity/chemotaxis; Motor Q9BW19 3833 6p21.32 human S26-p 477789 RPLIKAPsQLPLSGS protein stabilization; ubiquitination cell cycle regulation; carcinogenesis, induced; DNA repair, induced; chromatin organization, altered 33397932 3 11 36 inhibits ubiquitination +CERT1 COL4A3BP EC 2.7.11.9; KINASE; Kinase, protein; Lipid-binding; Protein kinase, Ser/Thr (non-receptor); Protein kinase, atypical Q9Y5P4 10087 5q13.3 human S144-p 125104502 VSGASGYsATSTSSF molecular association, regulation; activity, inhibited 28652409 0 1 0 reduced PtdIns(4)P binding affinity as well as low ceramide transfer activity, E494R/N495K/P535R/E537K mutations, recovery of both PtdIns(4)P binding and ceramide transfer activity. +Pnma5 PNMA5 Apoptosis Q5DTT8 385377 X|X A7.3 mouse T553-p 125108500 ELRMPTGtEAAQGVE intracellular localization 29228573 1 0 0 regulates meiosis through Akt-GSK3b pathway +Acadvl ACADVL EC 1.3.8.9; Lipid Metabolism - fatty acid; Mitochondrial; Oxidoreductase P50544 11370 11 B3|11 42.96 cM mouse C238-sn 63237400 SSAIPSPcGKYYTLN Acyl-CoA_dh_M enzymatic activity, induced 23281369 1 1 0 +Nrip1 RIP140 Nuclear receptor co-regulator; Transcription, coactivator/corepressor Q8CBD1 268903 16|16 C3.1 mouse R948-m1 2363400 LLSENCVrDLSPHRS NRIP1_repr_4 transcription, induced 19216533 2 2 0 +Zap70 ZAP70 EC 2.7.10.2; KINASE; Kinase, protein; Protein kinase, TK; Protein kinase, tyrosine (non-receptor) P43404 22637 1 B|1 15.41 cM mouse Y314-p 448867 MPMDTSVyESPYSDP protein degradation; molecular association, regulation; ubiquitination; protein conformation; phosphorylation CD3Z(INDUCES); VAV1(INDUCES) 11828374; 26936881; 35860252 12 4 265 +RANBP3 RANBP3 Adaptor/scaffold Q9H6Z4 8498 19p13.3 human S126-p 460735 VKRERTSsLTQFPPS molecular association, regulation; intracellular localization; activity, inhibited RAN(INDUCES) 18280241 3 46 126 inhibits RCC1 activity +Tp53 p53 Activator; DNA-binding; Motility/polarity/chemotaxis; Nuclear receptor co-regulator; Transcription factor; Tumor suppressor P02340 22059 11 B3|11 42.83 cM mouse S312-p 447530 LPTCTSAsPPQKKKP acetylation carcinogenesis, altered; transcription, altered 15794754; 20962274 49 32 7 S312AA knock-in mice are more suseptible to tumorigenesis. ; substitution of either alanine or aspartic acid at this site induces acetylation at K370 (K373 in human) +NBN NBS1 Cell cycle regulation; DNA repair, damage O60934 4683 8q21.3 human K690-ac 487514 KNFKKFKkVTYPGAG Nbs1_C phosphorylation cell cycle regulation; apoptosis, induced; DNA repair, inhibited 17612497; 28869605 3 1 0 +ATP2A2 SERCA2 Cell adhesion; EC 3.6.3.8; Endoplasmic reticulum; Hydrolase; Membrane protein, integral; Membrane protein, multi-pass; Transporter; Transporter, ion channel P16615 488 12q24.11 human K585-sm 25092200 EDSANFIkYETNLTF protein stabilization; molecular association, regulation; ubiquitination; enzymatic activity, induced Other(INDUCES) 21900893 2 0 0 induces ATP binding, inhibits ubiquitination +XRCC1 XRCC1 DNA repair, damage P18887 7515 19q13.31 human S485-p 451510 QDNGAEDsGDTEDEL molecular association, regulation; intracellular localization PARP1(DISRUPTS); Pnk1(INDUCES) 15066279; 25477519 3 16 0 +Magi1 MAGI1 Cell adhesion; Motility/polarity/chemotaxis Q6RHR9 14924 6|6 D1 mouse S733-p 3896422 QPLERKDsQNSSQHS MAGI_u5 activity, induced; intracellular localization 30944250 2 11 35 induces NF-KB and Rap1 activity and EC activation +GYPA GYPA Adaptor/scaffold; Membrane protein, integral P02724 2993 4q31.21 human T36-gl 12726309 TSTSSSVtKSYISSQ Glycophorin_A protein conformation 7681597 1 0 0 The structure or conformation of three consecutive Ser/Thr residues may be necessary for its antigenicity. +GLI3 GLI3 C2H2-type zinc finger protein; Transcription factor P10071 2737 7p14.1 human S907-p 15501388 TDASRRSsEASQSDG protein processing transcription, inhibited 10693759 1 0 0 +SNCA SNCA Adaptor/scaffold P37840 6622 4q22.1 human K96-sm 3755605 AAATGFVkKDQLGKN Synuclein ubiquitination; protein processing apoptosis, inhibited 21746851; 25607946; 29180403 5 1 0 +Wasf1 WAVE1 Cytoskeletal; Motility/polarity/chemotaxis Q5BJU7 rat S441-p 7979602 PPGIRPSsPVTVAAL intracellular localization cytoskeletal reorganization 19460862 4 0 0 +HSPB6 HSP20 Chaperone; Heat shock protein F1RM62 pig S16-p 450706 PSWLRRAsAPLPGLS Crystallin molecular association, regulation ACTG1(INDUCES) 10790164 21 31 2 +THRA TR-alpha DNA-binding; Nuclear receptor; Transcription factor NP_990644 396251 chicken K387-sm 27490405 ASRFLHMkVECPTEL Hormone_recep molecular association, regulation transcription, altered Src(INDUCES); N-CoR1(INDUCES) DNA(DISRUPTS) 27843805 3 0 0 +Irx3 IRX3 DNA-binding P81067 16373 8 C5|8 44.55 cM mouse S361-p 1874748504 SLAETATsPDNPRRS molecular association, regulation; intracellular localization transcription, induced IRX3(INDUCES) 34556885 1 1 0 IRX3 dimerization, nuclear translocation +AFP AFP Secreted; Secreted, signal peptide P02771 174 4q13.3 human K194-ac 1879738503 KIIPSCCkAENAVEC ubiquitination carcinogenesis, induced; cell motility, induced; cell growth, induced; apoptosis, inhibited 31811908 1 1 0 inhibits ubiquitination, promotes the migration and invasion +Cacna1b CACNA1B Channel, calcium; Membrane protein, integral; Membrane protein, multi-pass Q02294 257648 3p13 rat S2132-p 465550 YSCDRFGsREPPQPK activity, induced 16704976; 19167461 2 0 0 +TWIST1 TWIST1 Cell development/differentiation; DNA-binding; Inhibitor; Transcription regulation Q15672 7291 7p21.1 human S68-p 18905000 GGGDEPGsPAQGKRG molecular association, regulation; protein stabilization; ubiquitination; intracellular localization carcinogenesis, induced; carcinogenesis, altered; cell motility, induced; apoptosis, inhibited; transcription, induced; transcription, altered E2A(INDUCES); NFkB-p65(INDUCES) 21502402; 26959880; 26975371; 31540485; 34881782 5 13 0 protects Twist1 from ubiquitination; ; upregulates expression of POSTN and PDGFRa; inhibits ubiquitination; promotes TGFbeta-induced cell invasion +NCOA3 SRC-3 ACETYLTRANSFERASE; Acetyltransferase; EC 2.3.1.48; Motility/polarity/chemotaxis; Nuclear receptor co-regulator; Transcription, coactivator/corepressor Q9Y6Q9 8202 20q13.12 human Y1357-p 4668109 HPQAASIyQSSEMKG molecular association, regulation transcription, altered; cell growth, altered p300(INDUCES); CARM1(INDUCES); ER-alpha(INDUCES) 18765637 1 1 0 +PLCG1 PLCG1 Carbohydrate Metabolism - inositol phosphate; EC 3.1.4.11; Motility/polarity/chemotaxis; Phospholipase P19174 5335 20q12 human K54-sm 1879811200 ERKTFQVkLETRQIT activity, induced; molecular association, regulation; phosphorylation SLP76(INDUCES); GADS(INDUCES) 30873169 1 0 0 T-cell activation, microcluster formation and Ca2+ flux, slightly promotes phosphorylation of Y783 +PTK2 FAK EC 2.7.10.2; KINASE; Kinase, protein; Protein kinase, TK; Protein kinase, tyrosine (non-receptor) Q00944 396416 chicken Y397-p 447887 SVSETDDyAEIIDEE molecular association, regulation Src(INDUCES) 10816598; 7509446 371 31 474 +Rap1gap RAP1GAP GAP; GAP, Ras; Motility/polarity/chemotaxis XP_233609 313644 5q36 rat S472-p 1210678 VIRSRSQsMDAMGLS cytoskeletal reorganization 19218462 1 19 72 controls dendritic spine morphology +SLC6A4 SERT Membrane protein, integral; Membrane protein, multi-pass; Transporter P31645 6532 17q11.2 human S611-p 7576400 FKERIIKsITPETPT activity, induced; molecular association, regulation Vimentin(DISRUPTS) 19270731 1 0 1 +TRAF6 TRAF6 EC 6.3.2.-; Ligase; UBIQUITIN LIGASE; Ubiquitin conjugating system; Ubiquitin ligase Q9Y4K3 7189 11p12 human Y288-p 1869056900 SVIPDSGyISEVRNF activity, induced; ubiquitination TAK1(INDUCES); TAB2(INDUCES) 32403971 2 0 0 +HMGN2 HMGN2 DNA-binding P05204 3151 1p36.11 human S25-p 3146800 KDEPQRRsARLSAKP HMG14_17 intracellular localization 10739259 2 12 5 Phosphorylation facilitates localization to non-nuclear pools. +Scarb1 SCARB1 Membrane protein, integral; Membrane protein, multi-pass; Receptor, misc. P97943 25073 12q15 rat K508-ub 21184146 GTVLQEAkL______ protein degradation 28669731 1 3 0 +PREX1 PREX1 GEF; GEF, Rac/Rho Q8TCU6 57580 20q13.13 human S1165-p 25256104 DSGHDTMsYRDSYSE enzymatic activity, inhibited 22242915 1 1 0 +CDC6 CDC6 Cell cycle regulation Q99741 990 17q21.2 human K105-ac 8539501 FDNQLTIkSPSKREL intracellular localization cell cycle regulation 19343071 1 0 0 +Trpv1 TRPV1 Channel, cation; Membrane protein, integral; Membrane protein, multi-pass; Receptor, misc. O35433 83810 10q24 rat T406-p 473576 IAYSSSEtPNRHDML receptor desensitization, inhibited; molecular association, regulation; intracellular localization; protein conformation; activity, inhibited; phosphorylation KIF13B(INDUCES) 17194758; 26376215; 26902776 5 0 0 modulates oral pain related responses transduced via the TRPV1 channel, response of TRPV1 to heat is altered in the T406D mutant, modulates voltage-dependence +Hcn4 HCN4 Channel, cation; Membrane protein, integral; Membrane protein, multi-pass O70507 330953 9|9 B mouse T1138-p 15103405 HVTLPRKtSSGSLPP activity, induced 20713547 1 0 0 required for PKA to shift the voltage dependence of HCN4 +RAPGEF2 RAPGEF2 GEF; GEF, Ras; Motility/polarity/chemotaxis Q9Y4G8 9693 4q32.1 human S1244-p 30995201 ASLDAADsGRGSWTS protein degradation; molecular association, regulation; ubiquitination; enzymatic activity, inhibited carcinogenesis, induced; cell motility, induced BTRC(INDUCES) 24290981 1 0 0 inhibits Rap1 activity +PPARG PPAR-gamma DNA-binding; Nuclear receptor; Transcription factor P37231 5468 3p25.2 human K395-sm 12004433 FGDFMEPkFEFAVKF Hormone_recep carcinogenesis, inhibited; cell growth, inhibited; transcription, induced; transcription, altered 25409419; 26244663; 29137280 8 0 0 transcription of a subset of PPAR-gamma target genes involved in lipid metabolism +CREBBP CBP ACETYLTRANSFERASE; Acetyltransferase; DNA-binding; EC 2.3.1.48; Motility/polarity/chemotaxis; Nuclear receptor co-regulator; Transcription, coactivator/corepressor Q92793 1387 16p13.3 human R714-me 475950 PLSLPVNrMQVSQGM transcription, induced; signaling pathway regulation 12374746 1 0 0 steroid hormone signaling, GRIP1 and steroid hormone-induced transcription +RIOK2 RIOK2 EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, Ser/Thr (non-receptor); Protein kinase, atypical Q9BVS4 55781 5q15 human S380-p 3211080 PEQIKEDsLSEESAD cell cycle regulation 21880710 1 29 6 +Slitrk3 SLITRK3 Cell surface; Membrane protein, integral Q810B9 386750 3|3 E3 mouse Y969-p 465425 KLQTKPDyLEVLEKT molecular association, regulation gephyrin(INDUCES) 31551708 1 0 1 regulates synapse development +CHFR CHFR EC 6.3.2.-; EC 6.3.2.19; Ligase; UBIQUITIN LIGASE; Ubiquitin conjugating system; Ubiquitin ligase Q96EP1 55743 12q24.33 human K663-sm 27992500 ICEQTRFkN______ protein degradation cell growth, induced 23131550 1 0 0 +Itgb1 ITGB1 Cell adhesion; Cell surface; Membrane protein, integral; Motility/polarity/chemotaxis; Receptor, misc. P09055 16412 8|8 E2 mouse S785-p 452040 GENPIYKsAVTTVVN Integrin_b_cyt cell adhesion, altered 19555977 5 11 17 +TARDBP TDP-43 RNA-binding Q13148 23435 1p36.22 human S403-p 3084617 GFNGGFGsSMDSKSS molecular association, regulation; intracellular localization; phosphorylation RNA splicing, inhibited; RNA stability, inhibited TDP-43(DISRUPTS) 22198567; 24466128; 34107054; 35112738 14 3 0 primes phosphorylation at other sites; promotes cytoplasmic aggregation +Slc4a3 SLC4A3 Membrane protein, integral; Membrane protein, multi-pass; Transporter; Transporter, SLC family P23348 24781 9q33 rat S67-p 10212000 EKPSRSYsERDFEFH activity, induced 11739292; 28677776 2 1 0 SLC4A3 exchange activity, inhibits H/R-induced ROS production +Sdc2 syndecan-2 Cell adhesion; Cell surface; Membrane protein, integral; Motility/polarity/chemotaxis P34900 25615 7q22 rat Y179-p 448375 RKKDEGSyDLGERKP Syndecan molecular association, regulation cytoskeletal reorganization EphB2(INDUCES) 11580899 2 2 6 +DPYSL5 CRMP-5 Q9BPU6 56896 2p23.3 human T516-p 478232 TPLADTPtRPVTRHG molecular association, regulation cell growth, inhibited TUBA1A(INDUCES) 25040932 1 2 0 +TRAF2 TRAF2 Autophagy; EC 6.3.2.-; Ligase; UBIQUITIN LIGASE; Ubiquitin conjugating system; Ubiquitin ligase Q12933 7186 9q34.3 human S11-p 5397201 ASVTPPGsLELLQPG activity, induced; molecular association, regulation; ubiquitination carcinogenesis, induced; cell growth, induced; apoptosis, inhibited; signaling pathway regulation RIPK1(INDUCES); IKKB(INDUCES); cIAP1(DISRUPTS); IKKG(INDUCES) 18981220; 23007157; 24362534 6 15 0 +ATAD3A ATAD3A iso2 Mitochondrial Q9NVI7-2 55210 1p36.33 human K135-ac 11322823 ARAQYQDkLARQRYE ATAD3_N molecular association, regulation; activity, inhibited ATAD3A(DISRUPTS) 30914652 1 3 1 dimerization of ATAD3A is promoted by deacetylation of ATAD3A and Drp1-mediated mitochondrial fragmentation +HIF1A HIF1A Autophagy; DNA-binding; Transcription factor Q16665 3091 14q23.2 human K477-ub 21176130 LNQEVALkLEPNPES protein degradation carcinogenesis, inhibited; cell motility, inhibited; transcription, inhibited 29180628 2 3 0 +INSR INSR EC 2.7.10.1; KINASE; Kinase, protein; Membrane protein, integral; Protein kinase, TK; Protein kinase, tyrosine (receptor) P06213 3643 19p13.2 human S1033-p 454090 LRELGQGsFGMVYEG PK_Tyr_Ser-Thr phosphorylation 10819237 5 0 0 alanine mutations of S1033, S1062, and S1064 increases tyrosine autophosphorylation of InsR +NRG1 NRG1 iso6 Cell development/differentiation; Cytokine; Ligand, receptor tyrosine kinase; Membrane protein, integral; Motility/polarity/chemotaxis Q02297-6 3084 8p12 human S286-p 28076401 LHDRLRQsLRSERNN Neuregulin protein processing 23720309 2 2 0 induced cleavage +RPS6KA5 MSK1 EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, AGC; Protein kinase, Ser/Thr (non-receptor) O75582 9252 14q32.11 human S360-p 448215 TEMDPTYsPAALPQS Pkinase_C protein conformation; enzymatic activity, induced 17446865 6 1 15 +Syt2 SYT2 Calcium-binding; Lipid-binding; Membrane protein, integral; Vesicle P46097 20980 1 E4|1 58.24 cM mouse T202-p 454031 ETKVHRKtLNPAFNE C2 molecular association, regulation 15350218 1 0 0 phosphorylation of this site modulates synaptotagmin II binding to phospholipid vesicles (via its C2 domain) +Mafa MAFA DNA-binding; Oncoprotein; Transcription factor; Tumor suppressor Q8CF90 378435 15|15 D3 mouse S61-p 1320401 PLSTPCSsVPSSPSF protein degradation; molecular association, regulation transcription, inhibited MAFA(INDUCES); PSME3(INDUCES) DNA(NOT_REPORTED) 20208071; 21646385 4 0 0 +TEC TEC EC 2.7.10.2; KINASE; Kinase, protein; Protein kinase, TK; Protein kinase, tyrosine (non-receptor) P42680 7006 4p12-p11 human Y519-p 447891 RYVLDDQyTSSSGAK PK_Tyr_Ser-Thr enzymatic activity, induced 14679216 1 20 322 autophosphorylation site 519F mutant is unable to phosphorylate BDP1 +Socs3 SOCS3 Inhibitor O35718 12702 11|11 E2 mouse Y221-p 450447 IREFLDQyDAPL___ cell cycle regulation; carcinogenesis, inhibited; cell growth, inhibited 31255914 4 0 0 +PTPN1 PTP1B EC 3.1.3.48; Motility/polarity/chemotaxis; PHOSPHATASE; Phosphatase; Protein phosphatase, tyrosine (non-receptor) P18031 5770 20q13.13 human Y153-p 449314 SEDIKSYyTVRQLEL Y_phosphatase molecular association, regulation INSR(INDUCES) 8999839 2 0 0 +HSP90AA1 HSP90A Chaperone; Heat shock protein P07900 3320 14q32.31 human K419-ac 33362015 IRKNLVKkCLELFTE HSP90 molecular association, regulation apoptosis, induced TSC1(INDUCES) 31645902 1 1 0 +BMAL1 BMAL1 DNA-binding; Transcription factor O00327 406 11p15.3 human K259-sm 3055600 KCNRPSVkVEDKDFP protein degradation; intracellular localization transcription, induced 18644859 2 1 0 +EDC4 EDC4 RNA processing Q6P2E9 23644 16q22.1 human S107-p 23101593 IVASSDSsISSKARG RNA stability, altered 30467221 1 0 1 increase formation of P bodies +DRD2 DRD2 iso2 GPCR, family 1; Membrane protein, integral; Membrane protein, multi-pass; Receptor, GPCR P14416-2 1813 11q23.2 human S228-p 487432 KRVNTKRsSRAFRAH 7tm_1 receptor desensitization, induced; receptor recycling, induced 23082996 2 0 0 PKC mediated receptor desensitization and internalization +Pdcd1 PD-1 Apoptosis; Membrane protein, integral Q02242 18566 1|1 D mouse Y248-p 50293001 TACVHTEyATIVFTE molecular association, regulation cell differentiation, altered; carcinogenesis, induced; cell growth, induced; transcription, altered SHP-2(INDUCES) 26359984; 36581713 4 0 0 +PKM PKM Carbohydrate Metabolism - glycolysis and gluconeogenesis; Carbohydrate Metabolism - pyruvate; EC 2.7.1.40; KINASE; Kinase, other; Mitochondrial; Nucleotide Metabolism - purine P14618 5315 15q23 human K311-sc 33357166 EKVFLAQkMMIGRCN PK protein conformation; enzymatic activity, induced 28614718 1 1 0 Promotes PKM2 Tetramer-to-Dimer Transition and Protein Kinase Activity +Zc3h12a MCPIP1 EC 3.1.-.-; Hydrolase Q5D1E7 230738 4|4 D2.2 mouse S439-p 22730006 CLDSGIGsLESQMSE protein degradation; molecular association, regulation; ubiquitination; phosphorylation RNA stability, induced; transcription, induced BTRC(INDUCES) 22037600; 31072819; 34636324 3 1 0 phosphorylation followed by degradation of ZC3H12A (aka regnase-1) augments IL-6 mRNA stability; induces phosphorylation of STAT3 +TOP1 TOP1 EC 5.99.1.2; Isomerase; Nucleolus; Oncoprotein P11387 7150 20q12 human K103-sm 2793908 ASGDAKIkKEKENGF intracellular localization 12149243 2 1 0 +BLM BLM DNA repair, damage; DNA replication; EC 3.6.4.12; Helicase P54132 641 15q26.1 human S144-p 467079 KKLEFSSsPDSLSTI BLM_N cell cycle regulation 16864798 1 5 2 prevents early mitotic exit, necessary for mitotic arrest +IP6K2 IHPK2 EC 2.7.4.21; Kinase, other; Motility/polarity/chemotaxis Q9UHH9 51447 3p21.31 human S347-p 478422 RPEVVLDsDAEDLED IPK protein degradation; ubiquitination apoptosis, induced; cell growth, altered TRAF2(INDUCES) DNA(INDUCES) 17379600; 21262846 2 2 0 induces NFkB-DNA binding +FUS hnRNP P2 DNA-binding; Nuclear receptor co-regulator; Oncoprotein; RNA splicing; RNA-binding; SUMO LIGASE P35637 2521 16p11.2 human S277-p 1232880 DQGSRHDsEQDNSDN molecular association, regulation hnRNP P2(DISRUPTS) 35753345 1 9 2 +KIF23 KIF23 iso2 Microtubule-binding; Motility/polarity/chemotaxis; Motor Q02241-2 9493 15q23 human S708-p 2902205 IRLRHRRsRSAGDRW MKLP1_Arf_bdg activity, induced; intracellular localization cell cycle regulation; cytoskeletal reorganization 20451386; 30728176 5 1 0 induce centralspindlin oligomerization, RhoA activation and cytokinesis initiation. Prevent furrow regression +Ezh2 EZH2 EC 2.1.1.43; METHYLTRANSFERASE; Methyltransferase; Methyltransferase, protein lysine Q61188 14056 6 B2.3|6 22.92 cM mouse T416-p 10417699 EANSRCQtPIKMKPN activity, induced carcinogenesis, induced 31704972 5 7 7 supresses ER alpha expression +Ksr1 KSR KINASE; Kinase, protein; Protein kinase, Ser/Thr (non-receptor); Protein kinase, TKL Q61097 16706 11 B5|11 46.74 cM mouse Y728-p 3428057 LSHDWLCyLAPEIVR PK_Tyr_Ser-Thr protein stabilization; molecular association, regulation; protein conformation; phosphorylation; enzymatic activity, induced cell growth, inhibited BRAF iso1(DISRUPTS); MEK1(INDUCES) 24158441 1 1 0 delay cell proliferation, increases MEK activation and phosphorylation by BRAF +Myo3a MYO3A Actin-binding; EC 2.7.11.1; KINASE; Kinase, protein; Motor; Protein kinase, STE; Protein kinase, Ser/Thr (non-receptor) Q8K3H5 667663 2|2 A3 mouse S177-p 36841902 GVSAQLSsTRHRLNT Pkinase enzymatic activity, induced 21895655 2 2 0 +IL10RA IL10RA Membrane protein, integral; Receptor, cytokine Q13651 3587 11q23.3 human Y446-p 449607 AAVAFQGyLRQTRCA molecular association, regulation CSRP1(INDUCES) 12802285 2 0 0 +Fus hnRNP P2 DNA-binding; Nuclear receptor co-regulator; Oncoprotein; RNA splicing; RNA-binding; SUMO LIGASE P56959 233908 7|7 F3 mouse Y6-p 1869633701 __MASNDyTQQATQS intracellular localization 32678881 1 0 0 Induce fibrotic signaling +BECN1 beclin 1 Adaptor/scaffold; Autophagy; Membrane protein, peripheral Q14457 8678 17q21.31 human Y352-p 28850301 KSKELPLyCSGGLRF APG6 molecular association, regulation cell differentiation, inhibited; carcinogenesis, induced; autophagy, inhibited Bcl-2(INDUCES); beclin 1(INDUCES); rubicon(INDUCES); PIK3C3(DISRUPTS) 24034250; 29610308 2 0 0 kinase active HER2 +Prkd1 PRKD1 Autophagy; EC 2.7.11.13; KINASE; Kinase, protein; Motility/polarity/chemotaxis; Protein kinase, CAMK; Protein kinase, Ser/Thr (non-receptor) Q9WTQ1 85421 6q22 rat S744-p 448589 ARIIGEKsFRRSVVG Pkinase enzymatic activity, induced 11410586 58 14 20 +Cdk16 CDK16 Cell cycle regulation; EC 2.7.11.22; KINASE; Kinase, protein; Motility/polarity/chemotaxis; Protein kinase, CMGC; Protein kinase, Ser/Thr (non-receptor) Q04735 18555 X A1.3|X 16.18 cM mouse S119-p 453450 EDINKRLsLPADIRL molecular association, regulation CCNYL1(INDUCES) 26305884 4 60 0 +DVL3 DVL3 Motility/polarity/chemotaxis Q92997 1857 3q27.1 human S612-p 3830508 SDHTTRSsLRGPRER Dsh_C intracellular localization 24993822 1 1 1 +TGM2 TGM2 EC 2.3.2.13; KINASE; Transferase P21980 7052 20q11.23 human S212-p 22636600 KNAGRDCsRRSSPVY signaling pathway regulation 22142843 1 0 0 activation of Akt-signaling pathway, downregulation of EGFR +PPP1R16B PPP1R16B Motility/polarity/chemotaxis; Protein phosphatase, regulatory subunit Q95N27 282091 cow S337-p 486245 SSLSRRTsSAGSRGK cytoskeletal reorganization 17609201 2 0 0 +Gata1 GATA1 DNA-binding; Transcription factor P17679 14460 X A1.1|X 3.59 cM mouse S72-p 451234 EAEAYRHsPVFQVYP protein degradation; acetylation; ubiquitination; phosphorylation DNA(INDUCES) 16858405 3 0 2 Phosphorylation and acetylation cause the degradation of acetylated GATA-1; DNA binding is required for MAPK-dependent phosphorylation +TP53 p53 Activator; DNA-binding; Motility/polarity/chemotaxis; Nuclear receptor co-regulator; Transcription factor; Tumor suppressor P04637 7157 17p13.1 human K321-ne 486298 SSPQPKKkPLDGEYF P53_tetramer activity, inhibited transcription, inhibited 17098746 1 0 0 +HECTD3 HECTD3 EC 6.3.2.-; EC 6.3.2.19; Ligase; UBIQUITIN LIGASE; Ubiquitin conjugating system; Ubiquitin ligase Q5T447 79654 1p34.1 human S95-p 150180310 PLRAARDsIELRRGA molecular association, regulation apoptosis, inhibited CASP9(INDUCES) 28716524 1 1 0 +Erbb3 HER3 EC 2.7.10.1; KINASE; Kinase, protein; Membrane protein, integral; Oncoprotein; Protein kinase, TK; Protein kinase, tyrosine (receptor) Q62799 29496 7q11 rat Y1273-p 449857 AGGAGGDyAAMGACP molecular association, regulation; phosphorylation PIK3CB(INDUCES); PIK3R1(INDUCES) 11546794 3 6 57 induces phosphorylation of Akt1. +PPM1D PPM1D Cell cycle regulation; EC 3.1.3.16; Motility/polarity/chemotaxis; Nuclear receptor co-regulator; PHOSPHATASE; Protein phosphatase, Ser/Thr (non-receptor) O15297 8493 17q23.2 human S85-p 28847901 PLPDAGAsPAPSRCC PP2C protein degradation; ubiquitination DNA repair, induced; signaling pathway regulation 23871434 1 7 0 protein stabilization takes place after IR treatment and ATM activation +ETV6 Tel DNA-binding; Motility/polarity/chemotaxis; Oncoprotein; Transcription factor P41212 2120 12p13.2 human K99-sm 2884400 KALLLLTkEDFRYRS SAM_PNT intracellular localization transcription, induced; transcription, inhibited 12626745; 18022807 2 0 0 +MAFG MAFG Cell cycle regulation; DNA-binding O15525 4097 17q25.3 human K71-ac 458966 YAASCRVkRVTQKEE bZIP_Maf molecular association, regulation DNA(INDUCES) 11154691 1 0 0 +MAPK7 ERK5 EC 2.7.11.24; KINASE; Kinase, protein; Protein kinase, CMGC; Protein kinase, Ser/Thr (non-receptor) Q13164 5598 17p11.2 human S720-p 3195185 VTQQLSKsQVEDPLP intracellular localization; enzymatic activity, inhibited transcription, altered 20667468 1 6 0 +UVRAG UVRAG Autophagy Q9P2Y5 7405 11q13.5 human S571-p 7447346 KGEDLVGsLNGGHAN enzymatic activity, induced 26139536 1 7 0 alters lysosomal morphology and lysosomal tubulation +Yap1 YAP1 Oncoprotein; Transcription, coactivator/corepressor P46938 22601 9|9 A1 mouse S352-p 471290 GTPNAVSsPGMSQEL intracellular localization cell cycle regulation; cytoskeletal reorganization; signaling pathway regulation 33046882 8 29 12 Hippo pathway +RBM24 RBM24 Q9BX46 221662 6p22.3 human S181-p 556485000 DQYPYAAsPAAAGYV translation, induced 29358667 1 0 0 p53 expression +CAV2 caveolin-2 Adaptor/scaffold; Motility/polarity/chemotaxis P51636 858 7q31.2 human Y27-p 454430 SHHSGLEyADPEKFA Caveolin intracellular localization; phosphorylation cell growth, induced; transcription, inhibited 15504032; 22819829 6 9 33 Smad3 phosphorylation inhibited, PAI-1 protein expression supressed +Shank3 SHANK3 Adaptor/scaffold Q9JLU4 59312 7q34 rat S685-p 3844913 PPPKRAPsTTLTLRS molecular association, regulation Abi-1(INDUCES); Abi-2(INDUCES) 30610205; 31983435 2 5 1 +RET Ret EC 2.7.10.1; KINASE; Kinase, protein; Membrane protein, integral; Oncoprotein; Protein kinase, TK; Protein kinase, tyrosine (receptor) P07949 5979 10q11.21 human K1107-ub 31839904 MLSPSAAkLMDTFDS protein degradation; phosphorylation 24425877 1 0 0 Y341 phosphorylation increases Ret ubquitylation +Nfkbia IkB-alpha DNA-binding; Inhibitor Q63746 25493 6q23 rat S32-p 448203 LVDDRHDsGLDSMKD activity, induced; intracellular localization apoptosis, altered; transcription, induced; transcription, altered 11490015; 16316997; 16407217; 35842713 161 3 17 A S32A,S36A double mutant of IkBA inhibits the NFkB/p65-induced increase in dor (delta opiod receptor) promoter transcription; Cells expressing IKBa S32A S36A are more susceptible to apoptosis while in suspension than cells expressing wt IKBa.; inhibits nuclear translocation of p65-p50 +Stat4 STAT4 DNA-binding; Transcription factor P42228 20849 1 C1.1|1 26.67 cM mouse S722-p 447789 PSDLLPMsPSAYAVL activity, induced cell differentiation, altered; transcription, altered 10961885; 12213961 5 3 0 +SOX10 SOX10 Cell development/differentiation; DNA-binding; Transcription factor P56693 6663 22q13.1 human T244-p 628303300 GPPTPPTtPKTELQS sumoylation; molecular association, regulation; activity, inhibited transcription, inhibited UBC9(DISRUPTS) 29295999 2 2 0 inhibits sumoylation +AURKC AurC EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, Other; Protein kinase, Ser/Thr (non-receptor) Q9UQB9 6795 19q13.43 human T198-p 455456 TPSLRRKtMCGTLDY Pkinase enzymatic activity, induced 27332895 7 11 83 +GAB1 GAB1 Adaptor/scaffold; Motility/polarity/chemotaxis Q13480 2549 4q31.21 human Y472-p 447947 EPIQEANyVPMTPGT molecular association, regulation SHP-2(INDUCES); PIK3R1(INDUCES) 10978177; 9658397 7 0 2 +TRIM65 TRIM65 Ubiquitin conjugating system Q6PJ69 201292 17q25.1 human S367-p 1868914502 RGPGGPGsFELWQVQ carcinogenesis, inhibited; signaling pathway regulation 31332286 1 1 0 dephosphorylated form (6A mutant) contributes to TRIM65 function in tumor progression +KIF23 KIF23 Microtubule-binding; Motility/polarity/chemotaxis; Motor Q02241 9493 15q23 human S812-p 2902205 IRLRHRRsRSAGDRW MKLP1_Arf_bdg molecular association, regulation LIMK1(INDUCES) 25786116 5 1 0 activation of LIMK1 on centrosomes +NR1H4 NR1H4 iso2 DNA-binding; Nuclear receptor Q96RI1-2 9971 12q23.1 human T442-p 3333402 GRLTELRtFNHHHAE Hormone_recep activity, induced; intracellular localization 18668687 1 0 1 +KIF4A KIF4A Microtubule-binding; Motor O95239 24137 Xq13.1 human S1186-p 459846 KKTPPAPsPFDLPEL molecular association, regulation; intracellular localization cell cycle regulation; chromatin organization, altered CNAP1(INDUCES); SMC2L1(INDUCES) 30576375 1 15 3 chromosome binding and scaffold formation +Dlg1 DLG1 Adaptor/scaffold; Motility/polarity/chemotaxis Q62696 25252 11q22 rat S442-p 5931300 YLGQTPAsPARYSPI PDZ_assoc molecular association, regulation; intracellular localization cytoskeletal reorganization GKAP1(DISRUPTS) 15729360 3 2 10 +PPP2R2B PPP2R2B iso2 Apoptosis; Mitochondrial; Motility/polarity/chemotaxis; Protein phosphatase, regulatory subunit Q00005-2 5521 5q32 human S22-p 25554902 PNTILSSsCHTEADI intracellular localization; phosphorylation apoptosis, inhibited 22583914 1 0 0 induces phosphorylation of Drp1 and regulates mitochondrial fragmentation and OMM translocation of beta B2 +Tp53 p53 Activator; DNA-binding; Motility/polarity/chemotaxis; Nuclear receptor co-regulator; Transcription factor; Tumor suppressor P10361 24842 10q24 rat S15-p 447490 MSIELPLsQETFSCL P53_TAD protein stabilization; intracellular localization apoptosis, induced 12534344; 34529316; 35390676; 35917315 480 12 0 +Cdk4 CDK4 Cell cycle regulation; EC 2.7.11.22; KINASE; Kinase, protein; Protein kinase, CMGC; Protein kinase, Ser/Thr (non-receptor) P30285 12567 10|10 D3 mouse T172-p 448476 YSYQMALtPVVVTLW Pkinase enzymatic activity, induced 8139570 12 4 3 +CCDC106 CCDC106 Q9BWC9 29903 19q13.42 human S147-p 1867984200 SGASEEGsASERRRQ CCDC106 molecular association, regulation; intracellular localization carcinogenesis, induced; cell motility, induced; cell growth, induced; apoptosis, inhibited; signaling pathway regulation p53(INDUCES) 30885251 1 0 0 +Shc1 SHC1 iso2 Adaptor/scaffold; Apoptosis; Mitochondrial; Motility/polarity/chemotaxis P98083-2 20416 3 F1|3 39.11 cM mouse Y240-p 448510 EPPDHQYyNDFPGKE molecular association, regulation; phosphorylation cell motility, induced; cell motility, altered GRB2(INDUCES) 18273058; 23277357 29 22 943 angiogenesis; required for ErbB2- and TGFB mediated tumor metastasis to the lungs.; metastatic spread of tumors; required for migration and invasion of ERB2-expressing cells +KDR VEGFR2 EC 2.7.10.1; KINASE; Kinase, protein; Membrane protein, integral; Protein kinase, TK; Protein kinase, tyrosine (receptor) P35968 3791 4q12 human Y996-p 447904 EEAPEDLyKDFLTLE PK_Tyr_Ser-Thr molecular association, regulation; receptor internalization, altered; enzymatic activity, induced signaling pathway regulation PLCG1(INDUCES) 10102632; 25119572 7 0 0 +SRC Src EC 2.7.10.2; KINASE; Kinase, protein; Oncoprotein; Protein kinase, TK; Protein kinase, tyrosine (non-receptor) P12931 6714 20q11.23 human S104-p 8149769 SRTETDLsFKKGERL SH3_1 protein degradation; molecular association, regulation FBXL7(INDUCES); FBW1B(DISRUPTS) 32839549 1 4 1 +Ctnnd1 CTNND1 Actin-binding; Adaptor/scaffold; Cell adhesion; G protein regulator, misc.; Motility/polarity/chemotaxis P30999 12388 2 D|2 49.45 cM mouse S288-p 450452 GLEDDQRsMGYDDLD molecular association, regulation; intracellular localization carcinogenesis, induced; cell adhesion, inhibited Kaiso(INDUCES) 21468542; 26175155 7 35 27 decreased homophilic binding affinity of E-cadherin +TP53 p53 Activator; DNA-binding; Motility/polarity/chemotaxis; Nuclear receptor co-regulator; Transcription factor; Tumor suppressor P04637 7157 17p13.1 human S6-p 447537 __MEEPQsDPSVEPP P53_TAD activity, induced; molecular association, regulation; acetylation; protein conformation; phosphorylation apoptosis, altered; apoptosis, induced; transcription, induced; transcription, altered 11875057; 12860987; 14665630; 15471885; 18769132; 18794113; 21454683 34 2 1 increased p21 expression +ANK3 ANK3 Adaptor/scaffold; Motility/polarity/chemotaxis Q12955 288 10q21.2 human S2417-p 38552200 SRVNTPVsQEEDSRP molecular association, regulation SPTBN4(INDUCES) 25552556 1 0 0 +Abra ABRA Actin-binding; Contractile; Transcription, coactivator/corepressor Q8K4K7 286965 7q31 rat T62-p 1255792402 ATQDLPHtPKEPGPR transcription, induced 30210579 1 1 0 +STIL STIL Cell cycle regulation; Cell development/differentiation; Oncoprotein Q15468 6491 1p33 human S1108-p 17549173 DRSTVGLsLISPNNM molecular association, regulation; intracellular localization cytoskeletal reorganization SAS6(INDUCES) 26101219 1 1 0 promotes centriole duplication, centriole recruitment of STIL +GALNT2 GALNT2 EC 2.4.1.41; Glycan Metabolism - O-glycan biosynthesis; Membrane protein, integral; Transferase Q10471 2590 1q42.13 human S109-ac 25336511 NKFNQVEsDKLRMDR enzymatic activity, inhibited; O-GalNAc glycosylation 21651894 0 1 0 inhibits glycosylation of mucin +OPA1 OPA1 Apoptosis; EC 3.6.5.5; Hydrolase; Membrane protein, integral; Mitochondrial O60313 4976 3q29 human K926-ac 31068000 EDGEKKIkLLTGKRV OPA1_C enzymatic activity, inhibited 24344202 1 1 0 regulation of mitochondrial dynamics, morphology and function +Sh3bp2 SH3BP2 Adaptor/scaffold Q06649 24055 5|5 B2 mouse Y446-p 449093 EEDSDEDyEKVPLPN molecular association, regulation LYN(INDUCES) 12709437 5 0 0 over expression of SH3BP2 leads to Lyn autophosphorylation +Txnip TXNIP Apoptosis; Mitochondrial; Motility/polarity/chemotaxis; Tumor suppressor Q8BG60 56338 3 F2.1|3 41.93 cM mouse S309-p 277409200 GLSSRTSsMASRTSS endocytosis, induced 28591573 2 0 0 glucose uptake +CLDN1 Claudin-1 Cytoskeletal; Membrane protein, integral; Membrane protein, multi-pass O95832 9076 3q28 human T191-p 1869121000 CSCPRKTtSYPTPRP intracellular localization 31398894 1 0 0 regulates Claudin-1 tight junction localization +CTPS1 CTPS EC 6.3.4.2; Ligase; Motility/polarity/chemotaxis; Nucleotide Metabolism - pyrimidine P17812 1503 1p34.2 human S462-p 479852 TLFQTKNsVMRKLYG GATase enzymatic activity, induced cell growth, altered 17463002 1 0 0 +TP53 p53 Activator; DNA-binding; Motility/polarity/chemotaxis; Nuclear receptor co-regulator; Transcription factor; Tumor suppressor P04637 7157 17p13.1 human T150-p 456327 VQLWVDStPPPGTRV P53 protein degradation; molecular association, regulation; ubiquitination cell cycle regulation; cell growth, inhibited; apoptosis, induced; transcription, induced PIN1(INDUCES); FBXO42(INDUCES) DNA(INDUCES) 17906639; 21127074 4 0 8 +Tp53 p53 Activator; DNA-binding; Motility/polarity/chemotaxis; Nuclear receptor co-regulator; Transcription factor; Tumor suppressor P10361 24842 10q24 rat K380-ac 458977 QSTSRHKkPMIKKVG activity, induced; activity, inhibited apoptosis, induced; apoptosis, inhibited 18192848; 35850611 216 10 0 Tolfenamic acid decreased the apoptotic positive cellular rate from 11.91 to 7.47%; tolfenamic acid significantly increased the phosphorylation level of p53 at the Ser378 site andreduced the acetylation level at the Lys382 site site, suggesting that tolfenamic acid may reduce the activity of p53 +EPHA2 EphA2 EC 2.7.10.1; KINASE; Kinase, protein; Membrane protein, integral; Protein kinase, TK; Protein kinase, tyrosine (receptor) P29317 1969 1p36.13 human Y588-p 450859 QLKPLKTyVDPHTYE EphA2_TM activity, induced; molecular association, regulation; enzymatic activity, induced carcinogenesis, induced; cell differentiation, altered; cell motility, induced; cell motility, altered; cell adhesion, altered VAV2(INDUCES); NCK1(INDUCES); VAV3(INDUCES) 18387945; 19193766; 32005975 8 26 649 +CDKN1A p21Cip1 Cell cycle regulation; Inhibitor P38936 1026 6p21.2 human K163-ub 9897004 RLIFSKRkP______ protein degradation; ubiquitination cell cycle regulation; carcinogenesis, induced; cell growth, induced 13678583; 17429006; 28446751 5 0 0 +RNF40 RNF40 EC 6.3.2.-; EC 6.3.2.19; Ligase; UBIQUITIN LIGASE; Ubiquitin conjugating system; Ubiquitin ligase O75150 9810 16p11.2 human S114-p 18710201 ALLRCHEsQGELSSA ubiquitination DNA repair, induced 21362549 1 0 0 induces H2B-K125 ubiquitylation +NEDD1 NEDD1 Cell cycle regulation Q8NHV4 121441 12q23.1 human S460-p 20609205 STSVLHSsPLNVFMG molecular association, regulation; intracellular localization; phosphorylation cell cycle regulation PLK1(INDUCES) 21690413 2 3 0 +MAVS MAVS Adaptor/scaffold; Membrane protein, integral Q7Z434 57506 20p13 human T342-gl 1872691006 AVPSNALtNPAPSKL phosphorylation 31461653 1 1 0 positively regulates phosphorylation of S442 (data from MAVS 7A mutant) +Numb NUMB Cell development/differentiation Q2LC84 29419 6q24 rat S294-p 470030 SPFKRQLsLRINELP NumbF molecular association, regulation AP2A1(DISRUPTS); AP2B1(DISRUPTS); 14-3-3 eta(INDUCES) 17022975 4 9 17 +AMPH amphiphysin Vesicle P49418 273 7p14.1 human T387-p 469997 LPWDLWTtSTDLVQP molecular association, regulation CLTC(DISRUPTS) 16945112 1 0 0 +MIF MIF Amino Acid Metabolism - phenylalanine; Amino Acid Metabolism - tyrosine; Apoptosis; Cell development/differentiation; Cytokine; EC 5.3.2.1; EC 5.3.3.12; Isomerase P14174 4282 22q11.23 human K78-ac 461652 AQNRSYSkLLCGLLA MIF intracellular localization apoptosis, inhibited AIF1(DISRUPTS) 35585040 1 8 22 impaired MIF interaction with AIF and nuclear translocation, protect neuronal death, reduces ischemia-induced brain injury +MYC Myc DNA-binding; Nucleolus; Oncoprotein; Transcription factor P01106 4609 8q24.21 human T263-p 1876391102 HEETPPTtSSDSEEE Myc_N protein degradation; molecular association, regulation; ubiquitination FBXW7(INDUCES) 35089787 1 0 0 +LTB4R LTB4R GPCR, family 1; Membrane protein, integral; Membrane protein, multi-pass; Receptor, GPCR Q15722 1241 14q12 human T308-p 455505 VAKLLEGtGSEASST receptor internalization, induced; receptor desensitization, altered signaling pathway regulation 12077128; 22707565; 30131369 4 2 0 enhanced ligand-induced internalization ; chemotaxis, B-hexisaminidase release, regulates LTB4R function +Foxo1 FOXO1A DNA-binding; Nuclear receptor co-regulator; Oncoprotein; Transcription factor Q9R1E0 56458 3 C|3 23.19 cM mouse S316-p 449113 TFRPRTSsNASTISG intracellular localization transcription, inhibited 10698940 29 5 27 +EIF3H eIF3S3 Translation; Translation initiation O15372 8667 8q23.3-q24.11 human S183-p 471116 VCKEKDFsPEALKKA eIF3h_C activity, induced cell growth, altered 18544531 1 30 2 +TBL1XR1 TBL1XR1 Nuclear receptor co-regulator; Transcription, coactivator/corepressor Q9BZK7 79718 3q26.32 human S204-p 2509600 NLSENSTsGSTQLVL transcription, induced 18374649 1 0 0 +CDK2 CDK2 Cell cycle regulation; EC 2.7.11.22; KINASE; Kinase, protein; Protein kinase, CMGC; Protein kinase, Ser/Thr (non-receptor) P24941 1017 12q13.2 human Y15-p 447740 EKIGEGTyGVVYKAR Pkinase protein stabilization; enzymatic activity, inhibited; protein conformation cell cycle regulation 11298456; 12912980; 13678583; 1396589; 14551212; 15632290; 17095507; 18927589; 23671119; 26240362; 34156324 33 129 3845 +Ppp1r3a PPP1R3A Membrane protein, integral; Protein phosphatase, regulatory subunit Q99MR9 140491 6|6 A1 mouse S67-p 449321 TSASRRVsFADSLGF molecular association, regulation PPA1(DISRUPTS) 24244723 6 1 0 +HSPB8 HSPB8 Heat shock protein Q9UJY1 26353 12q24.23 human S27-p 7994902 PFRDSPLsSRLLDDG protein conformation 21526341 2 1 0 decrease chaperone activity +Scnn1g ENaC-gamma Channel, sodium; Membrane protein, integral; Membrane protein, multi-pass; Transporter, ion channel P37091 24768 1q36 rat K6-ub 486250 __MAPGEkIKAKIKK receptor recycling, inhibited; protein degradation; intracellular localization 9351815 1 0 0 +KDM3A JMJD1A DEMETHYLASE; Demethylase; EC 1.14.11.-; Nuclear receptor co-regulator; Oxidoreductase Q9Y4C1 55818 2p11.2 human S264-p 8100021 IGAVKRKsSENNGTL molecular association, regulation chromatin organization, altered; transcription, induced STAT1(INDUCES) 25535969 2 9 1 +HSF1 HSF1 DNA-binding; Transcription factor Q00613 3297 8q24.3 human K298-ac 31953301 SSPLVRVkEEPPSPP Vert_HS_TF protein stabilization; protein conformation 24581496 1 1 0 +MAPK1 ERK2 EC 2.7.11.24; KINASE; Kinase, protein; Protein kinase, CMGC; Protein kinase, Ser/Thr (non-receptor) P28482 5594 22q11.22 human S246-p 6845001 HILGILGsPSQEDLN Pkinase molecular association, regulation; intracellular localization cell growth, induced IPO7(INDUCES); NUP153(DISRUPTS) 18760948; 21730285 2 1 0 +Adcy6 ADCY6 Adenylyl cyclase; EC 4.6.1.1; Lyase; Membrane protein, integral; Membrane protein, multi-pass; Nucleotide Metabolism - purine; Transporter; Transporter, aquaporin family AAA40678 25289 7q36 rat S750-p 467274 LSRSIVRsRVHSTAV enzymatic activity, induced 11327830; 15470083 2 0 0 increases potentiation +MRE11 MRE11A Cell cycle regulation; DNA repair, damage; DNA-binding; Deoxyribonuclease P49959 4361 11q21 human R570-me 2344812 SAATNKGrGRGRGRR intracellular localization 15970667 1 0 0 localizes in nucleus and associates with nuclear bodies and sites of DNA damage +NTRK1 TrkA iso2 EC 2.7.10.1; KINASE; Kinase, protein; Membrane protein, integral; Oncoprotein; Protein kinase, TK; Protein kinase, tyrosine (receptor) P04629-2 4914 1q23.1 human Y675-p 447764 DIYSTDYyRVGGRTM PK_Tyr_Ser-Thr activity, induced; intracellular localization; enzymatic activity, induced; phosphorylation cell differentiation, induced 27655914; 29229648; 9099755 14 3 6 neurite outgrowth and differentiation +Vasp VASP Cytoskeletal; Motility/polarity/chemotaxis P70460 22323 7|7 A3 mouse S235-p 448380 GAKLRKVsKQEEASG molecular association, regulation; intracellular localization cytoskeletal reorganization; transcription, altered ACTR3B(DISRUPTS); Arp3(DISRUPTS); ACTG1(DISRUPTS); MYO1C(DISRUPTS); Abl iso4(INDUCES); MYO5A(DISRUPTS); ARP2(DISRUPTS); MYO1B(DISRUPTS) 12087107; 33976159; 36350314; 37019383 62 26 3 +Tnnt2 TNNT2 Motility/polarity/chemotaxis; Motor P50752 21956 1 E4|1 59.32 cM mouse T216-p 451556 RKSGKRQtEREKKKK Troponin activity, inhibited 12832403 7 0 0 +WNK4 WNK4 EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, Other; Protein kinase, Ser/Thr (non-receptor) Q96J92 65266 17q21.2 human S1022-p 1871464501 GRFQVTSsKEPAEPL molecular association, regulation; ubiquitination ubiquitin(INDUCES) 33376515 1 0 0 +SQSTM1 SQSTM1 Autophagy; Nuclear receptor co-regulator; Ubiquitin conjugating system Q13501 8878 5q35.3 human K7-ub 55588403 _MASLTVkAYLLGKE activity, induced; protein degradation; molecular association, regulation autophagy, induced SQSTM1(DISRUPTS) 26942676; 35100065 2 0 0 OTUD7B enhances SQSTM1 oligomerzation activity to promote IRF3 degradation; TRIM1 ubiquitylation abrogates oligomerization and sequestering client proteins -Keap1 +IQCB1 IQCB1 Cell development/differentiation Q15051 9657 3q13.33|3q21.1 human K205-ub 15491986 DLLRIGRkALYSILD intracellular localization cell cycle regulation; cytoskeletal reorganization 28498859 1 3 1 regulation of cilia formation +STAT5A STAT5A DNA-binding; Motility/polarity/chemotaxis; Oncoprotein; Transcription factor P42229 6776 17q21.2 human S780-p 448750 DSLDSRLsPPAGLFT molecular association, regulation; intracellular localization carcinogenesis, induced; carcinogenesis, inhibited; cell growth, inhibited; apoptosis, induced; transcription, altered; transcription, inhibited ERK1(DISRUPTS) 10194762; 31932645; 34188118 12 25 0 +Kcnj8 KCNJ8 Channel, potassium; Membrane protein, integral; Membrane protein, multi-pass Q63664 25472 4q44 rat S385-p 483976 NSLRKRNsMRRNNSM activity, induced; activity, inhibited 15087422; 18048350 3 0 0 +CHRM2 mAChR M2 GPCR, family 1; Membrane protein, integral; Membrane protein, multi-pass; Receptor, GPCR P08172 1129 7q33 human T310-p 459108 QDENTVStSLGHSKD 7tm_1 receptor desensitization, altered; receptor internalization, altered 9162044 3 0 0 Mutation of 4 S/T to A eliminates receptor desensitization in response to carbachol treatment (as measured by isoproterenol-stimulated cAMP production after pretreatment with carbachol).; Mutation of S286 T287 S288 S290 to A caused a faster rate and a greater extent of receptor internalization after agonist stimulation (transients only, not observed in stables). Mutation of all 8 sites prevented internalization (in both transients and stables). +GCM1 GCM1 DNA-binding; Transcription factor Q9NP62 8521 6p12.1 human S47-p 20745200 YAKHIYSsEDKNAQR GCM sumoylation; molecular association, regulation transcription, induced SENP1(INDUCES) 21791615 1 1 0 induces GCM1 desumoylation, Epac regulates placental cell fusion via GCM1 +MAPK3 ERK1 EC 2.7.11.24; KINASE; Kinase, protein; Protein kinase, CMGC; Protein kinase, Ser/Thr (non-receptor) P27361 5595 16p11.2 human T202-p 447542 HDHTGFLtEYVATRW Pkinase activity, induced; protein degradation; molecular association, regulation; intracellular localization; protein conformation; phosphorylation; enzymatic activity, induced cell cycle regulation; carcinogenesis, induced; apoptosis, altered; apoptosis, induced; cell motility, induced; cell motility, inhibited; signaling pathway regulation; cell growth, induced; cell motility, altered; transcription, inhibited; cell growth, altered; cell differentiation, inhibited; carcinogenesis, inhibited; cell growth, inhibited; transcription, induced; transcription, altered; autophagy, induced; cell differentiation, induced; apoptosis, inhibited; autophagy, inhibited; cytoskeletal reorganization TACE(INDUCES); leupaxin(NOT_REPORTED); GSK3B(INDUCES); KSR(INDUCES) 10597231; 10925301; 11352917; 12368275; 12609989; 12808105; 12917346; 12952943; 15004239; 16149052; 16397900; 16585161; 17562849; 17667937; 17685427; 18042541; 18045996; 18519681; 18658095; 18775330; 19088846; 19106095; 19144315; 20122898; 20228268; 20231899; 20868520; 21478863; 21530327; 21561860; 21685939; 21726627; 21730054; 21893193; 21917714; 21980390; 22385658; 23644655; 24632852; 25538243; 26073130; 26079947; 26586479; 27323830; 28574827; 30987999; 31722981; 31736979; 31933886; 32081857; 32107290; 33627405; 33667549; 33731431; 33820494; 33828192; 34017102; 34209868; 34226680; 34262144; 34380633; 34473994; 34480897; 34497368; 34588619; 34611296; 34611309; 34642304; 34675408; 34743207; 34921013; 34992144; 35173310; 35293964; 35367211; 35414784; 35439648; 35544764; 36053753; 36216931; 36289618; 36346366; 36455198; 36509141; 36529291; 36966223; 37016335; 7535768; 8444886 1343 110 2017 +ITGA2 ITGA2 Cell adhesion; Membrane protein, integral; Motility/polarity/chemotaxis; Receptor, misc. P17301 3673 5q11.2 human S1180-p 3181118 IDETTELsS______ molecular association, regulation MST1(INDUCES) 27765911 1 4 0 +Tbx2 TBX2 DNA-binding; Transcription factor Q60707 21385 11 C|11 51.34 cM mouse S623-p 1308917 ARPRLRFsPYQIPVT activity, induced; protein stabilization; intracellular localization transcription, inhibited 18025091 1 0 0 relocalizes into nuclei after UV radiation +Snap25 SNAP-25 Vesicle P60879 20614 2 F3|2 67.56 cM mouse S187-p 448668 RIMEKADsNKTRIDE activity, inhibited neural plasticity; exocytosis, altered 12417653; 18162553; 28801590; 35309682 15 1 0 +Myb Myb DNA-binding; Oncoprotein; Transcription factor P06876 17863 10 A3|10 9.75 cM mouse T572-p 1308922 LTSSVLMtPVSEDED protein degradation; ubiquitination cell differentiation, induced; transcription, induced 18006338; 19421138; 21092141; 32873855 4 0 0 induces transcription of itself to compensate for post translational modifications +Cacnb2 CACNB2 Channel, calcium Q8VGC3 116600 17q12.3 rat S530-p 451474 KSQHRSSsATHQNHR activity, induced 10567342 4 1 0 +Shc1 SHC1 Adaptor/scaffold; Apoptosis; Mitochondrial; Motility/polarity/chemotaxis P98083 20416 3 F1|3 39.11 cM mouse K81-ac 63115300 AGGRLGPkGEPGKAA intracellular localization; phosphorylation 28137876 1 1 0 induces phosphorylation at S36 +PPM1B PPM1B EC 3.1.3.16; Motility/polarity/chemotaxis; PHOSPHATASE; Protein phosphatase, Ser/Thr (non-receptor) O75688 5495 2p21 human S195-p 27461503 MIQRVNGsLAVSRAL PP2C protein degradation; ubiquitination 23756813 1 4 0 inhibition of anti-inflammatory response +PIK3R1 PIK3R1 KINASE; Kinase, lipid; Motility/polarity/chemotaxis P23727 282307 cow Y688-p 448137 FAEPYNLySSLKELV SH2 molecular association, regulation PIK3R1(INDUCES) 11337495 3 0 0 phosphorylation of this site increases activity of PI3K lipid kinase and modulates transcription through NFkB +MAPK7 ERK5 EC 2.7.11.24; KINASE; Kinase, protein; Protein kinase, CMGC; Protein kinase, Ser/Thr (non-receptor) Q13164 5598 17p11.2 human K6-sm 2887213 __MAEPLkEEDGEDG molecular association, regulation; intracellular localization cell growth, induced; transcription, induced HSP90A(DISRUPTS) 32209980 4 0 0 nuclear translocation; Hsp90 dissociation from the ERK5-Cdc37 complex +Cdkn1b p27Kip1 Cell cycle regulation; Inhibitor; Oncoprotein; Protein kinase, regulatory subunit P46414 12576 6 G1|6 65.77 cM mouse S175-p 28058801 NRTEENVsDGSPNAG phosphorylation 23602409 1 3 0 induces phosphorylation at T183 +ASXL2 ASXL2 DNA-binding Q76L83 55252 2p23.3 human R641-m2 27269954 SQVSPRArFPVSITS cell differentiation, inhibited; apoptosis, inhibited; transcription, inhibited MLL3(DISRUPTS) DNA(DISRUPTS) 36197977 1 2 8 CARM1 inhibition up-regulates apoptosis and differentiation related genes +RECQL4 RECQL4 EC 3.6.4.12; Helicase O94761 9401 8q24.3 human S89-p 25173042 LNRAATKsPQSTPGR Drc1-Sld2 molecular association, regulation; ubiquitination; intracellular localization DNA repair, induced WDHD1(INDUCES); DDB1(INDUCES); MRE11A(INDUCES); GINS4(INDUCES) 29229926; 31519754 2 6 0 enhances the helicase activity; DNA end resection and HR ; induces activation of replication origin; promotes its ubiquitination by DDB1-CUL4A E3 ubiquitin ligase; recruitment to DSBs +ELK1 ELK1 DNA-binding; Transcription factor P19419 2002 Xp11.23 human K230-sm 3982502 PPEAPNLkSEELNVE sumoylation; intracellular localization cell differentiation, inhibited; transcription, induced; transcription, inhibited 14992729; 15210726; 17036045; 30789974 6 2 0 Both ELK1 and ELK-3R promote transcription, K230R, K249R, K254R does not prevent ELK1 SUMOylation, ELK1 and ELK1-3R show same intracellular localization +BCAR1 P130Cas Adaptor/scaffold; Motility/polarity/chemotaxis P56945 9564 16q23.1 human Y234-p 449639 AQPEQDEyDIPRHLL cell growth, induced 26867768 3 31 698 metastases +CFTR CFTR Channel, chloride; EC 3.6.3.49; Hydrolase; Membrane protein, integral; Membrane protein, multi-pass; Transporter; Transporter, ABC family P13569 1080 7q31.2 human S1045-p 56689900 QQLKQLEsEGRSPIF ABC_membrane activity, induced; ubiquitination; receptor internalization, altered 27261451 1 0 0 S1045Y-CFTR exhibits a 50% reduction in channel function, accelerated internalization, docking of E3 ubiquitin ligase c-cbl +CLDN6 Claudin-6 Cell adhesion; Membrane protein, integral; Membrane protein, multi-pass P56747 9074 16p13.3 human Y196-p 7792482 GSQGPSHyMARYSTS cell adhesion, altered; signaling pathway regulation 31740618 1 0 17 +Ugcg UGCG EC 2.4.1.80; Lipid Metabolism - sphingolipid; Membrane protein, integral; Membrane protein, multi-pass; Transferase O88693 22234 4 32.44 cM|4 B3 mouse Y132-p 26420454 INNLMPAyEVAKYDL Glyco_transf_21 enzymatic activity, induced 32980536 1 0 1 regulation of cytotoxicity to ceramide +Runx1 AML1 DNA-binding; Oncoprotein; Transcription factor Q03347 12394 16 C4|16 53.7 cM mouse Y378-p 51211402 GSPSYHLyYGASAGS RunxI activity, induced; protein stabilization transcription, induced HDAC1(DISRUPTS) DNA(INDUCES) 26598521 1 0 0 +YAP1 YAP1 iso2 Oncoprotein; Transcription, coactivator/corepressor P46937-2 10413 11q22.1 human S61-p 484116 IVHVRGDsETDLEAL activity, inhibited cell differentiation, induced; cell growth, inhibited; transcription, inhibited 23027127; 23752589 13 47 1 +BARD1 BARD1 EC 6.3.2.-; EC 6.3.2.19; Ligase; UBIQUITIN LIGASE; Ubiquitin conjugating system; Ubiquitin ligase Q99728 580 2q35 human S184-p 455771 QDSYEFVsPSPPADV cell cycle regulation 15855157 1 4 0 resistance to genotoxic stress (mitomycin C) +INPP5D SHIP iso2 EC 3.1.3.86; Motility/polarity/chemotaxis; Phosphatase, lipid Q92835-2 3635 2q37.1 human Y864-p 454794 GKTREKLyDFVKTER intracellular localization 29852247 1 25 364 nucleocytoplasmic shuttling (A mutants show accumulation in nucleus) +XRCC6 Ku70 DNA repair, damage; DNA-binding; EC 3.6.4.-; EC 4.2.99.-; Helicase; Nuclear receptor co-regulator; RNA-binding P12956 2547 22q13.2 human K570-m3 1883494505 ELKTHISkGTLGKFT intracellular localization apoptosis, inhibited 35545041 1 0 0 enriched in cytoplasm, the methylation of KU70-K570 is a prerequisite for the acetylation of KU70 +Calm1 Calmodulin Calcium-binding; Protein phosphatase, regulatory subunit P0DP29 24242 6q32 rat S82-p 448705 RKMKDTDsEEEIREA molecular association, regulation; activity, inhibited; phosphorylation KCNQ4(INDUCES) 14736917; 24627475; 8206911 9 16 0 T80 site is key to binding. CAM phosphorylation regulates channel trafficking and stabilizes activity-thereby regulating neuronal excitability.; Calmodulin phosphorylated by CKII in vitro showed reduced activation of erythrocyte plasma membrane Ca2+ pump. +EEF2K EEF2K EC 2.7.11.20; KINASE; Kinase, protein; Protein kinase, Ser/Thr (non-receptor); Protein kinase, atypical; Translation O00418 29904 16p12.2 human S445-p 483529 SGDSGYPsEKRGELD protein degradation; molecular association, regulation; ubiquitination carcinogenesis, inhibited; cell growth, inhibited; translation, induced; translation, inhibited BTRC(INDUCES); BRD8(INDUCES) 22669845; 25670349; 35513296 5 29 8 +EHHADH EHHADH Amino Acid Metabolism - lysine degradation; Amino Acid Metabolism - tryptophan; Amino Acid Metabolism - valine, leucine and isoleucine degradation; Carbohydrate Metabolism - butanoate; Carbohydrate Metabolism - propanoate; EC 1.1.1.35; EC 4.2.1.17; EC 5.3.3.8; Isomerase; Lipid Metabolism - fatty acid; Lyase; Mitochondrial; Other Amino Acids Metabolism - beta-alanine; Oxidoreductase; Secondary Metabolites Metabolism - limonene and pinene degradation Q08426 1962 3q27.2 human K346-ac 461836 MITSVLEkEASKMQQ 3HCDH_N enzymatic activity, induced 20167786 0 5 3 +PINK1 PINK1 EC 2.7.11.1; KINASE; Kinase, protein; Membrane protein, integral; Mitochondrial; Protein kinase, Other; Protein kinase, Ser/Thr (non-receptor) Q9BXM7 65018 1p36.12 human S495-p 396518801 ALLQREAsKRPSARV Pkinase autophagy, induced 29284690 1 1 0 mitochondrial autophagy (mitophagy) +IRF2 IRF2 DNA-binding; Transcription factor P14316 3660 4q35.1 human K293-sm 3173814 PDLQVTIkEESNPVP transcription, inhibited 18514056 1 0 0 +FRS2 FRS2 Adaptor/scaffold Q8WU20 10818 12q15 human Y436-p 448154 LEHRQLNyIQVDLEG molecular association, regulation cell differentiation, induced; signaling pathway regulation SHP-2(INDUCES) 11278583; 36410439 6 1 0 activates FGFR1 signaling +ELK4 ELK4 DNA-binding; Transcription, coactivator/corepressor P28324 2005 1q32.1 human S381-p 4317600 IHFWSTLsPVAPLSP transcription, induced 9130707 2 0 0 +Ikbkb IKKB EC 2.7.11.10; KINASE; Kinase, protein; Protein kinase, Other; Protein kinase, Ser/Thr (non-receptor) O88351 16150 8|8 A2 mouse S682-p 17934901 SMNVSRLsHPGQLMS molecular association, regulation; phosphorylation PPP2R3C(INDUCES) 20925653 1 1 0 interaction with PPP2R3C (aka G4-1) downregulates IKK-beta activity; S181 phosphorylation increased in S679/682/689/692/697/701/705A mutant +XRCC6 Ku70 DNA repair, damage; DNA-binding; EC 3.6.4.-; EC 4.2.99.-; Helicase; Nuclear receptor co-regulator; RNA-binding P12956 2547 22q13.2 human K338-ac 458920 KEETEELkRFDDPGL Ku molecular association, regulation DNA repair, inhibited DNA(DISRUPTS) 17545612 3 4 1 +LLGL1 LLGL1 Cell adhesion; Cytoskeletal; Motility/polarity/chemotaxis Q15334 3996 17p11.2 human S670-p 10405473 SFRRIRKsRVSGKKR intracellular localization 34717957 1 0 1 +INVS INVS Q9Y283 27130 9q31.1 human S865-p 55578721 GARRLETsTLSEDFQ cytoskeletal reorganization 27220846 1 0 0 Akt2 plays a more prominent role in ciliary development than Akt1, tubular differentiation +Pld2 PLD2 EC 3.1.4.4; Lipid Metabolism - ether lipid; Lipid Metabolism - glycerophospholipid; Motility/polarity/chemotaxis; Phospholipase P97813 18806 11 B3|11 42.99 cM mouse Y11-p 450938 TQKNLFPyGDYLNSS molecular association, regulation; intracellular localization; phosphorylation; enzymatic activity, induced EGFR(NOT_REPORTED) 15282299; 9837959 2 0 1 +TH TH iso2 Amino Acid Metabolism - tyrosine; EC 1.14.16.2; Endoplasmic reticulum; Mitochondrial; Oxidoreductase; Vesicle P07101-2 7054 11p15.5 human S67-p 448545 RFIGRRQsLIEDARK TOH_N enzymatic activity, induced 7901013 62 11 11 +RBM17 RBM17 RNA splicing; RNA-binding; Spliceosome Q96I25 84991 10p15.1 human S48-p 27936101 KSQRTKQsTVLAPVI molecular association, regulation; phosphorylation RNA splicing, inhibited; cell motility, induced RNA(DISRUPTS) 23519612 1 0 0 induced cell invasion, enhanced Cortactin phosphorylation at ERK-dependent sites +PTH1R PTHR GPCR, family 2; Membrane protein, integral; Membrane protein, multi-pass; Receptor, GPCR Q03431 5745 3p21.31 human S491-p 452061 KRKARSGsSSYSYGP receptor internalization, induced; molecular association, regulation ARR3(INDUCES) 27623777 5 4 0 S503 AND T504 IN THE SECOND CLUSTER ARE RESPONSIBLE FOR 70% OF ARRESTIN3 RECRUITMENT +H3c1 H3 DNA-binding P68433 360198 13|13 A3.1 mouse S28-p 455677 ATKAARKsAPATGGV Histone molecular association, regulation chromatin organization, altered; transcription, induced; transcription, altered; cell growth, altered 14-3-3 zeta(INDUCES); 14-3-3 epsilon(INDUCES) DNA(INDUCES) 18381464; 20129940; 21460852 50 18 0 increases occupancy of Brf1 and TBP promoters +Ets1 Ets-1 DNA-binding; Motility/polarity/chemotaxis; Oncoprotein; Transcription factor P27577 23871 9 A4|9 17.97 cM mouse K15-sm 3656301 KPTLTIIkTEKVDLE transcription, inhibited 16729975; 16862185 3 1 0 +SNCA SNCA Adaptor/scaffold P37840 6622 4q22.1 human Y133-p 448280 EMPSEEGyQDYEPEA molecular association, regulation SNCA(DISRUPTS) 36690898 3 0 0 +Cnp CNP Cell development/differentiation; EC 3.1.4.37; Phosphodiesterase P13233 25275 10q31 rat K196-ac 1881330703 FGWFLTKkSSETLRK enzymatic activity, inhibited; protein conformation 34330062 1 1 0 +FLCN FLCN Tumor suppressor Q8NFG4 201163 17p11.2 human S542-p 23107127 LLSILGAsEEDNVKL Folliculin_C molecular association, regulation FNIP2(INDUCES); LC3B(DISRUPTS); GABARAP(DISRUPTS) 25126726 1 1 1 +SENP1 SENP1 DESUMOYLASE; EC 3.4.22.68; Nuclear receptor co-regulator; Protease; Sumo-specific protease Q9P0U3 29843 12q13.11 human Y270-p 1876335002 EQLSHSVySLSSYTP sumoylation; molecular association, regulation; enzymatic activity, inhibited SUMO1(INDUCES); SUMO3(INDUCES) 35186948 1 0 0 alters substrate desumoylation +ROCK2 ROCK2 EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, AGC; Protein kinase, Ser/Thr (non-receptor) Q28021 282041 cow T967-p 1732201 ELTEKDAtIASLEET enzymatic activity, induced cell cycle regulation 17446864 1 0 0 alanine mutation of all 4 sites +XRCC4 XRCC4 DNA repair, damage Q13426 7518 5q14.2 human S260-p 475982 KDDSIISsLDVTDIA XRCC4 DNA repair, induced 30247612 4 4 1 induces cell survival +NR1H3 LXR-alpha DNA-binding; Motility/polarity/chemotaxis; Nuclear receptor Q13133 10062 11p11.2 human K328-sm 12004412 YNREDFAkAGLQVEF Hormone_recep molecular association, regulation transcription, inhibited DNA(INDUCES) 17218271 2 0 0 +CCDC88C Daple Inhibitor Q9P219 440193 14q32.11-q32.12 human Y2025-p 899136400 PQTVWYEyGCV____ molecular association, regulation DVL1(DISRUPTS) 29487190 1 1 0 +PCYT1A PCYT1A EC 2.7.7.15; Lipid Metabolism - glycerophospholipid; Transferase P49585 5130 3q29 human S315-p 451321 GRMLQAIsPKQSPSS intracellular localization 32186954 4 67 13 +ARID4B ARID4B DNA-binding Q4LE39 51742 1q42.3 human K440-sm 12004426 ETEIKEIkMEEERNI cell cycle regulation; cell growth, inhibited; transcription, inhibited 16479010 1 1 0 +Ikbkg IKKG Adaptor/scaffold; Protein kinase, regulatory subunit O88522 16151 X|X A7.3 mouse S85-p 458399 ELLHFQVsQREEKEF NEMO activity, induced signaling pathway regulation 20932476 5 0 0 IKK activation, leading to TAK1 activation +TAOK1 TAO1 EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, STE; Protein kinase, Ser/Thr (non-receptor) Q7L7X3 57551 17q11.2 human T502-p 3627514 RLDKDLEtQRNNFAA activity, induced cell cycle regulation 17396146 1 0 0 +NBN NBS1 Cell cycle regulation; DNA repair, damage O60934 4683 8q21.3 human K441-ac 487510 TKLPSINkSKDRASQ phosphorylation cell cycle regulation; apoptosis, induced 17612497 2 1 0 inhibits phosphorylation at S343 +Clk2 CLK2 EC 2.7.12.1; KINASE; Kinase, protein; Protein kinase, CMGC; Protein kinase, dual-specificity (non-receptor) O35491 12748 3|3 F1 mouse Y99-p 26375902 DTDFRQSyEYHRENS protein degradation 20074525 1 0 0 +LRRK2 LRRK2 EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, Ser/Thr (non-receptor); Protein kinase, TKL Q5S007 120892 12q12 human T2035-p 477192 GIKTSEGtPGFRAPE Pkinase enzymatic activity, induced 20595391 5 1 0 +KHDRBS1 KHDRBS1 RNA-binding Q07666 10657 1p35.2 human R304-m2 476770 PPPVPRGrGVGPPRG intracellular localization 12529443 1 3 7 +MYC Myc DNA-binding; Nucleolus; Oncoprotein; Transcription factor P01106 4609 8q24.21 human K332-sm 40724412 AAPPSTRkDYPAAKR Myc_N protein degradation; ubiquitination transcription, inhibited 25895136 1 1 0 +SH2D1B SH2D1B Adaptor/scaffold O14796 117157 1q23.3 human Y127-p 4140135 FVNSNSDyVDVLP__ molecular association, regulation exocytosis, induced; cytoskeletal reorganization PLCG1(INDUCES); PLCG2(INDUCES) 24642916; 24687958 2 0 8 activating function of CD244 required the C-terminal tyrosine Y127, SH2D18 promoted MTOC and granule polarization and exocytosis +Lpcat2 AYTL1 ACETYLTRANSFERASE; Acetyltransferase; EC 2.3.1.23; EC 2.3.1.51; EC 2.3.1.67; Membrane protein, integral Q8BYI6 270084 8|8 C5 mouse S34-p 15146101 PMVPRQAsFFPPPVP enzymatic activity, induced 20663880; 24742674 2 3 0 increases biosynthesis of platelet-activating factor (PAF) +Mapk7 ERK5 EC 2.7.11.24; KINASE; Kinase, protein; Protein kinase, CMGC; Protein kinase, Ser/Thr (non-receptor) Q9WVS8 23939 11|11 B2 mouse S766-p 14561005 DSASLSAsLLADWLE transcription, altered 17928297 1 1 0 +Apbb1ip RIAM Adaptor/scaffold; Motility/polarity/chemotaxis Q8R5A3 54519 2|2 A3 mouse Y427-p 1871479101 AKYGKTLyDNYQRAV activity, induced; intracellular localization cell adhesion, induced; signaling pathway regulation 33275877 1 0 0 induces integrin activation/ integrin signaling pathway +Cdk1 CDK1 Cell cycle regulation; EC 2.7.11.22; EC 2.7.11.23; KINASE; Kinase, protein; Motility/polarity/chemotaxis; Protein kinase, CMGC; Protein kinase, Ser/Thr (non-receptor) P39951 54237 20p11 rat T161-p 447609 GIPIRVYtHEVVTLW Pkinase cell cycle regulation 36125973 44 43 83 +H2AZ1 H2AZ DNA-binding P0C0S5 3015 4q23 human K15-ub 12255514 DSGKAKTkAVSRSQR Histone intracellular localization DNA repair, induced 32424115 1 0 5 recruiting downstream DNA repair proteins to DNA breaks +KAT8 MYST1 ACETYLTRANSFERASE; Acetyltransferase; EC 2.3.1.48 Q9H7Z6 84148 16p11.2 human T392-p 34424910 LSQMTSItQNDIIST MOZ_SAS molecular association, regulation; intracellular localization DNA repair, induced; apoptosis, inhibited 53BP1(DISRUPTS) 24953651 1 0 0 DNA DSB repair by HR pathway, enhanced chromatin retention of MOF +Ciz1 CIZ1 Cell cycle regulation Q8VEH2 68379 2|2 B mouse T191-p 22648006 QARTPSStTPNRKDS activity, inhibited cell cycle regulation 15585571 1 0 0 DNA replication +NOS3 eNOS Amino Acid Metabolism - arginine and proline; EC 1.14.13.39; Oxidoreductase P29473 287024 cow S635-p 448637 WRRKRKEsSNTDSAG Flavodoxin_1 acetylation; phosphorylation; enzymatic activity, induced 12171920; 12591925; 16257964; 20479254 28 12 7 +HNF4A HNF4 alpha DNA-binding; Nuclear receptor; Transcription factor P41235 3172 20q13.12 human S143-p 458369 RISTRRSsYEDSSLP molecular association, regulation transcription, inhibited; signaling pathway regulation DNA(DISRUPTS) 21598922 4 3 12 PKA signaling pathway +Map3k14 Nik EC 2.7.11.25; KINASE; Kinase, protein; Protein kinase, STE; Protein kinase, Ser/Thr (non-receptor) Q9WUL6 53859 11 E1|11 66.8 cM mouse S862-p 27259003 GVKVQIQsLNGEHLH protein degradation 23023393 1 1 0 +MVB12A FAM125A Adaptor/scaffold Q96EY5 93343 19p13.11 human S170-p 3208938 SRDMQGLsLDAASQP DUF2464 protein processing 18005716 1 42 0 inhibition of HIV-1 release and infectivity +RAPH1 RAPH1 Adaptor/scaffold; Motility/polarity/chemotaxis Q70E73 65059 2q33.2 human Y466-p 457365 KYKAPTDyCLVLKHP PH molecular association, regulation cell motility, induced 26996666 1 0 3 Lpd-Scar/WAVE interaction is positively regulated by c-Abl and c-Src, breast cancer cell invasion +PAX3 PAX3 DNA-binding; Oncoprotein; Transcription factor P23760 5077 2q36.1 human S205-p 4145506 APQSDEGsDIDSEPD cell growth, inhibited 25821947 6 1 0 +DRD1 DRD1 GPCR, family 1; Membrane protein, integral; Membrane protein, multi-pass; Receptor, GPCR P21728 1812 5q35.2 human S431-p 458340 LDYDTDVsLEKIQPI molecular association, regulation signaling pathway regulation G-alpha(s)(INDUCES); ARR3(INDUCES) 32503917 2 0 0 ERK1/2 activation +IRF1 IRF1 Transcription factor; Tumor suppressor P10914 3659 5q31.1 human K275-sm 2134718 VYGDFSCkEEPEIDS protein stabilization; ubiquitination carcinogenesis, induced; apoptosis, inhibited; transcription, inhibited 17942705 1 0 0 inhibits ubiquitination +Crtc3 TORC3 Transcription, coactivator/corepressor Q91X84 70461 7|7 D3 mouse S329-p 468980 SGLQSSRsNPSIQAT molecular association, regulation transcription, inhibited 14-3-3 beta(INDUCES) 23033494 1 41 16 inhibits nuclear localization +Slc12a5 KCC2 Membrane protein, integral; Membrane protein, multi-pass; Transporter; Transporter, SLC family Q63633 171373 3q42 rat Y926-p 14932400 SDISAYTyEKTLVME SLC12 protein degradation 20600929 1 0 0 decreases the cell surface stability of SLC12A5 (aka KCC2) +RPL23A RPL23A Ribosomal; Translation P62750 6147 17q11.2 human K78-ub 22251150 LDHYAIIkFPLTTES Ribosomal_L23 protein degradation; ubiquitination transcription, altered 35637966 1 4 0 HERC3 could control protein expression and ubiquitination of c-Myc/p21 via RPL23A +Plk4 PLK4 EC 2.7.11.21; KINASE; Kinase, protein; Nucleolus; Protein kinase, Other; Protein kinase, Ser/Thr (non-receptor) Q64702 20873 3|3 B mouse S301-p 12654009 ITASSGTsLSGSLLD protein degradation; ubiquitination 20100909 2 1 0 +Nr4a1 Nur77 Apoptosis; DNA-binding; Nuclear receptor P12813 15370 15|15 F1 mouse K539-ub 1869841400 NRIASCLkEHMATVA Hormone_recep protein degradation 30224829; 33087562 2 0 0 +CDC25A CDC25A EC 3.1.3.48; Motility/polarity/chemotaxis; PHOSPHATASE; Protein phosphatase, dual-specificity P30304 993 3p21.31 human T80-p 4209300 RMGSSEStDSGFCLD protein degradation; molecular association, regulation; ubiquitination; phosphorylation GSK3B(INDUCES) 18167338 2 0 0 +Sod2 SOD2 EC 1.15.1.1; Mitochondrial; Oxidoreductase P09671 20656 17 A1|17 8.75 cM mouse K122-ac 475813 GELLEAIkRDFGSFE Sod_Fe_C intracellular localization; protein conformation; enzymatic activity, induced 28433661; 32606301 9 6 68 mediates pentameric SOD2 deaggregation; importation into mitochondria; in HFD WT Lipid peroxidation increased, but was attenuated in BLOC1S1-/- HFD mice +Gsk3b GSK3B EC 2.7.11.1; EC 2.7.11.26; KINASE; Kinase, protein; Protein kinase, CMGC; Protein kinase, Ser/Thr (non-receptor) Q9WV60 56637 16|16 B3 mouse S389-p 454221 ARIQAAAsPPANATA intracellular localization; enzymatic activity, inhibited; phosphorylation transcription, induced; signaling pathway regulation 18451303; 25477508; 26822034; 34948382 6 13 0 inhibits mTOR complex 1 signaling, primes phosphorylation at S9 and inhibits phosphorylation of p70S6K, enhances cardiomyocyte survival and protects from cardiomyocyte hypertrophy; NFAT transcription induced; nuclear GSK3B, V(D)J recombination +UBE2I UBC9 EC 6.3.2.-; EC 6.3.2.19; Ligase; Nuclear receptor co-regulator; SUMO LIGASE; SUMO conjugating system; SUMO ligase; UBIQUITIN LIGASE; Ubiquitin conjugating system; Ubiquitin ligase P63279 7329 16p13.3 human K153-sm 2344804 KRVRAQAkKFAPS__ sumoylation; molecular association, regulation RASD2(INDUCES) 20424159 2 3 0 RASD2 enhances sumoylation, induces sumoylation of SP100 +MAPRE1 EB1 Cytoskeletal; Motility/polarity/chemotaxis Q15691 22919 20q11.21 human T206-p 59049802 QVNVLKLtVEDLEKE molecular association, regulation; protein conformation cytoskeletal reorganization Restin(INDUCES); dynactin 1(INDUCES); TUBB(INDUCES) 27721984; 28039481 3 1 0 astral microtubule stability ; regulating astral microtubule stability and spindle orientation/positioning +DGKD DGKD EC 2.7.1.107; Kinase, lipid; Lipid Metabolism - glycerolipid; Lipid Metabolism - glycerophospholipid; Motility/polarity/chemotaxis Q16760 8527 2q37.1 human S70-p 452138 QNNSFQRsKRRYFKL PH intracellular localization 15228384 1 0 0 Phosphorylation appears to disrupt translocation of DAGK to the plasma membrane. +CLCN1 CLCN1 Channel, chloride; Membrane protein, integral; Membrane protein, multi-pass; Transporter; Transporter, ion channel P35523 1180 7q34 human S892-p 14645302 ASFRNTTsTRKSTGA activity, induced 20511714 1 0 1 +STAT5A STAT5A DNA-binding; Motility/polarity/chemotaxis; Oncoprotein; Transcription factor P42231 443419 sheep Y694-p 447767 LAKAVDGyVKPQIKQ activity, induced transcription, altered 7925280 156 50 2180 +WAC WAC Adaptor/scaffold Q9BTA9 51322 10p12.1|10p12.1-p11.2 human T471-p 469445 PIKPLIStPPVSSQP molecular association, regulation; phosphorylation cell cycle regulation PLK1(INDUCES) 30021153 1 9 31 +Brsk2 BRSK2 EC 2.7.11.1; EC 2.7.11.26; KINASE; Kinase, protein; Protein kinase, CAMK; Protein kinase, Ser/Thr (non-receptor) Q69Z98 75770 7|7 F5 mouse S456-p 4734903 PVHTPKEsPAGTPNP protein stabilization; enzymatic activity, inhibited; phosphorylation 23790753 1 3 0 inhibits axon branching (activated in BRSK2 18A mutant) +CDH2 CDH2 Cell adhesion; Membrane protein, integral; Motility/polarity/chemotaxis P19022 1000 18q12.1 human Y860-p 458305 DSLLVFDyEGSGSTA CADH_Y-type_LIR molecular association, regulation CTNNB1(DISRUPTS) 16371504 2 0 0 +SIK3 QSK EC 2.7.11.1; KINASE; Kinase, protein; Motility/polarity/chemotaxis; Protein kinase, CAMK; Protein kinase, Ser/Thr (non-receptor) Q9Y2K2 23387 11q23.3 human T221-p 456036 TPGQLLKtWCGSPPY Pkinase protein stabilization; molecular association, regulation; phosphorylation; enzymatic activity, induced 14-3-3 beta(INDUCES) 22588126; 35413286; 37477881 8 17 14 +Elk1 ELK1 DNA-binding; Transcription factor P41969 13712 X A1.3|X 16.45 cM mouse T364-p 22725902 LLPTHTLtPVLLTPS molecular association, regulation transcription, induced MED16(INDUCES); MED23(INDUCES); Trap100(INDUCES) 27738173 2 0 0 +Spag5 SPAG5 Cell cycle regulation Q7TME2 54141 11 B5|11 46.74 cM mouse S447-p 11270700 SSTQTDSsPCGVTKT cell cycle regulation 19806032 1 0 0 T24/66/447A mutant impairs meiosis progression +Trpm3 TRPM3 Channel, cation; Membrane protein, integral; Membrane protein, multi-pass Q5F4S9 226025 19|19 B mouse S1184-p 1875848400 CRWRKHEsDQDERDY activity, inhibited 34884938 1 0 0 +MYC Myc DNA-binding; Nucleolus; Oncoprotein; Transcription factor P01106 4609 8q24.21 human R361-me 1873076614 NRKCTSPrSSDTEEN molecular association, regulation transcription, induced p300(INDUCES); MAX(INDUCES) 28652407 1 1 0 proximity ligation assay (PLA) +TRIM28 TIF1B EC 6.3.2.-; KINASE; Kinase, protein; Ligase; Nuclear receptor co-regulator; Protein kinase, atypical; SUMO LIGASE; SUMO ligase; Transcription, coactivator/corepressor; UBIQUITIN LIGASE; Ubiquitin conjugating system; Ubiquitin ligase Q13263 10155 19q13.43 human S824-p 460839 LPGAGLSsQELSGGP activity, induced; sumoylation; molecular association, regulation; intracellular localization; phosphorylation cell cycle regulation; carcinogenesis, induced; carcinogenesis, inhibited; cell growth, inhibited; apoptosis, induced; transcription, induced; signaling pathway regulation; DNA repair, induced; translation, altered; chromatin organization, altered; apoptosis, inhibited; transcription, inhibited POLH(INDUCES); CHD-1(DISRUPTS); TRIM24(DISRUPTS) DNA(INDUCES) 16862143; 17942393; 20424263; 21642969; 21765463; 22205726; 22491012; 23645696; 25355892; 26212333; 28607002; 32060145; 32061892; 32156811; 34194047; 34518220; 34676045; 35339488; 37438603 47 9 6 +Dlg1 DLG1 Adaptor/scaffold; Motility/polarity/chemotaxis Q62696 25252 11q22 rat S158-p 2024309 FVSHSHIsPIKPTEA MAGUK_N_PEST molecular association, regulation; intracellular localization cytoskeletal reorganization GKAP1(DISRUPTS) 15729360 4 16 0 +Acss1 ACSS1 Carbohydrate Metabolism - glycolysis and gluconeogenesis; Carbohydrate Metabolism - propanoate; Carbohydrate Metabolism - pyruvate; EC 6.2.1.1; Ligase; Mitochondrial Q99NB1 68738 2|2 G3 mouse K635-ac 464663 LPKTRSGkVMRRLLR AMP-binding_C enzymatic activity, inhibited 16790548 2 2 0 +SLC6A3 DAT Membrane protein, integral; Membrane protein, multi-pass; Transporter; Transporter, SLC family Q01959 6531 5p15.33 human S7-p 451136 _MSKSKCsVGLMSSV activity, induced; molecular association, regulation; protein conformation Other(INDUCES) 15024426; 16908408; 23161550 6 1 1 increases DAT affinity for cocaine analog binding; stimulates DAT-mediated efflux of dopamine +Plekhf1 PKHF1 Q3TB82 72287 7|7 B3 mouse Y268-p 1868624701 WPTQVEFyASGVSWS molecular association, regulation endocytosis, induced; signaling pathway regulation caveolin-1(INDUCES) 31189603 1 0 0 endocytosis of bacteria +Ppp3ca PPP3CA EC 3.1.3.16; PHOSPHATASE; Protein phosphatase, Ser/Thr (non-receptor) P63329 24674 2q43 rat S411-p 2048309 GKMARVFsVLREESE intracellular localization; phosphorylation apoptosis, induced; signaling pathway regulation 19608982 1 4 1 inhibits phosphorylation and nuclear translocation of NFAT, regulates Calcineurin-NFAT signaling pathway +KIFC1 KIFC1 Microtubule-binding; Motility/polarity/chemotaxis; Motor Q9BW19 3833 6p21.32 human S6-p 12667678 __MDPQRsPLLEVKG protein stabilization cell cycle regulation 24510915 2 19 0 +Htt Huntingtin Cytoskeletal P42859 15194 5 B2|5 17.92 cM mouse S1159-p 465621 LTNPPSLsPIRRKGK intracellular localization cell differentiation, inhibited; exocytosis, inhibited; cell growth, inhibited; apoptosis, inhibited; transcription, inhibited 17611284; 23678106; 32640230 4 9 20 +Bcl2l11 BIM Apoptosis O54918 12125 2|2 F1 mouse S100-p 449602 FSFDTDRsPAPMSCD protein stabilization; molecular association, regulation apoptosis, altered; apoptosis, induced Bcl-2(INDUCES); Bcl-xL(INDUCES); BAX(DISRUPTS) 15486085; 23832115 8 2 0 +CASP2 CASP2 Apoptosis; EC 3.4.22.55; Protease P42575 835 7q34 human S139-p 6835500 LSCDYDLsLPFPVCE molecular association, regulation; protein processing; enzymatic activity, induced cell cycle regulation 14-3-3 zeta(INDUCES) 19203584; 28943433 2 2 0 +CEBPA C/EBP-alpha DNA-binding; Transcription factor P49715 1050 19q13.11 human R35-m1 1878324500 SAAFGFPrGAGPAQP cell cycle regulation; carcinogenesis, induced; cell growth, induced; transcription, inhibited HDAC3(DISRUPTS) 31015230 1 1 0 +CBLB Cbl-b Adaptor/scaffold; Calcium-binding; EC 6.3.2.-; Ligase; UBIQUITIN LIGASE; Ubiquitin conjugating system; Ubiquitin ligase Q13191 868 3q13.11 human Y363-p 455017 TQEQYELyCEMGSTF molecular association, regulation; ubiquitination; protein conformation; enzymatic activity, induced UBE2D1(INDUCES) 22158902; 26416283 3 9 75 +HNF4A HNF4 alpha DNA-binding; Nuclear receptor; Transcription factor P41235 3172 20q13.12 human K106-ac 460631 SRQCVVDkDKRNQCR zf-C4 molecular association, regulation; intracellular localization; protein conformation transcription, induced Exportin-1(DISRUPTS); CBP(INDUCES) DNA(INDUCES) 10882110 1 1 0 +Pcyt2 PCYT2 EC 2.7.7.14; Lipid Metabolism - glycerophospholipid; Transferase Q922E4 68671 11|11 E2 mouse S215-p 31834925 VSQFLQTsQKIIQFA enzymatic activity, induced cell growth, induced 24519946 1 1 0 +PTBP1 hnRNP I iso1 RNA splicing; RNA-binding P26599-1 5725 19p13.3 human S16-p 450288 AVGTKRGsDELFSTC intracellular localization 12851456 1 10 0 +Irs1 IRS1 Adaptor/scaffold; Motility/polarity/chemotaxis P35570 25467 9q34 rat Y1172-p 451288 GLEKSLNyIDLDLVK molecular association, regulation GRB2(INDUCES); SHP-2(INDUCES) 7504175; 7588273 5 6 21 +GNA13 G-alpha 13 G protein; G protein, heterotrimeric; G protein, heterotrimeric alpha G(12) Q14344 10672 17q24.1 human T203-p 448723 ILLARRPtKGIHEYD G-alpha molecular association, regulation TXA2-R iso2(INDUCES) 12399457 1 0 1 +BORA BORA Activator Q6PGQ7 79866 13q21.33 human S41-p 11452210 LHEQTLAsPSVFKST BORA_N molecular association, regulation cell cycle regulation PLK1(INDUCES) 27068477 2 2 0 +Igf2bp1 IGF2BP1 RNA-binding; Translation O88477 140486 11 D|11 59.08 cM mouse Y396-p 458348 SVTGAAPySSFMQAP cell growth, induced; translation, induced 21964071 6 0 0 optimally support axon outgrowth; localization release, and translation of GAP-43 mRNAs +PHLPP1 PHLPP EC 3.1.3.16; PHOSPHATASE; Protein phosphatase, Ser/Thr (non-receptor); Tumor suppressor O60346 23239 18q21.33 human S1359-p 22769300 VPRPHVQsVLLTPQD PP2C protein degradation 19797085 1 1 0 PHLPP phosphorylation induces degradation and Akt1 activation negatively regulates degradation. +MAPT Tau iso8 ACETYLTRANSFERASE; Acetyltransferase; Cytoskeletal P10636-8 4137 17q21.31 human T212-p 447934 TPGSRSRtPSLPTPP O-GlcNAc glycosylation; molecular association, regulation; intracellular localization; protein processing; protein conformation apoptosis, altered; cytoskeletal reorganization WWOX(INDUCES); Tau iso8(INDUCES); TUBA1A(INDUCES); PIN1(INDUCES) 15126504; 15190058; 15364924; 15542598; 16024016; 16987243; 18725412; 19451179; 20550628; 20663882 52 16 5 induced tau-tau association and formed aggregates in cell nucleus +TGM2 TGM2 EC 2.3.2.13; KINASE; Transferase P21980 7052 20q11.23 human T162-p 1874101934 ERQEYVLtQQGFIYQ intracellular localization DNA repair, induced 34225780 1 0 0 +AURKB AurB EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, Other; Protein kinase, Ser/Thr (non-receptor) Q96GD4 9212 17p13.1 human K85-ub 21129746 EIGRPLGkGKFGNVY Pkinase intracellular localization; enzymatic activity, induced 35853811 1 2 0 localization of TbRI in the midbody during cell division +BSG BSG Immunoglobulin superfamily; Membrane protein, integral P35613 682 19p13.3 human K375-ub 12408986 SGQHQNDkGKNVRQR carcinogenesis, induced; cell motility, induced; cell growth, induced; transcription, induced 26769849 1 2 4 +Ikbkb IKKB EC 2.7.11.10; KINASE; Kinase, protein; Protein kinase, Other; Protein kinase, Ser/Thr (non-receptor) O88351 16150 8|8 A2 mouse Y199-p 449633 ELLEQQKyTVTVDYW Pkinase phosphorylation; enzymatic activity, induced cell differentiation, induced; signaling pathway regulation 20534585; 30514903 6 1 0 Y188/199 of IKK? and Y179 TBK1 phosphorylation induce activation of TLR signaling; osteoclast differentiation +FHL2 FHL2 Motility/polarity/chemotaxis; Nuclear receptor co-regulator; Transcription, coactivator/corepressor Q14192 2274 2q12.2 human Y97-p 473390 TDCYSNEySSKCQEC LIM cell cycle regulation; cell growth, inhibited 33932144 1 1 5 +AR AR DNA-binding; Nuclear receptor; Transcription factor P10275 367 Xq12 human K633-ac 458905 TLGARKLkKLGNLKL activity, induced; protein stabilization; molecular association, regulation; intracellular localization; phosphorylation carcinogenesis, induced; carcinogenesis, inhibited; apoptosis, induced; transcription, induced; transcription, altered; signaling pathway regulation p300(INDUCES) 10779504; 11971970; 11994312; 15123687; 16860317; 17483368; 18022799; 22131404; 28511652 9 1 0 +CALD1 Caldesmon Actin-binding P12957 373965 chicken S642-p 15668102 SRLEQYTsAVVGNKA Caldesmon molecular association, regulation Caldesmon(DISRUPTS) 20858431 0 3 1 enhances effect of S672 and S702 phosphorylation to weaken interaction +ACTA1 ACTA1 Cell development/differentiation; Contractile; Cytoskeletal; Motility/polarity/chemotaxis P68135 rabbit K70-ac 474929 KRGILTLkYPIEHGI Actin activity, inhibited 30962575 1 6 10 CAP/actin inhibitory potency +HNRNPC hnRNP C1/C2 RNA splicing; RNA-binding; Spliceosome P07910 3183 14q11.2 human S299-p 448834 EGEDDRDsANGEDDS molecular association, regulation RNA(NOT_REPORTED) 15687492 3 64 87 +Ceacam1 CEACAM1 Cell adhesion; Immunoglobulin superfamily; Membrane protein, integral; Motility/polarity/chemotaxis P31809 26365 7 A3|7 13.84 cM mouse Y515-p 451429 PRATETVySEVKKK_ molecular association, regulation; intracellular localization SHP-2(INDUCES) 14970258; 9867848 5 2 37 +Htt Huntingtin Cytoskeletal P51111 29424 14q21 rat S1150-p 465621 LTNPPSLsPIRRKGK apoptosis, inhibited 17611284 4 9 20 regulates neuronal death through a p53-dependent pathway +F3 F3 Cell surface; Membrane protein, integral P20352 14066 3 G1|3 52.94 cM mouse S247-p 1874500400 VCTEQWKsFLGETLI cell growth, induced; apoptosis, inhibited 34359738 1 0 0 +KCNK9 KCNK9 Membrane protein, integral; Membrane protein, multi-pass Q9NPC2 51305 8q24.3 human T341-p 40686300 IEEISPStLKNSLFP activity, inhibited 17374744 1 0 0 PKCA mediated inhibition of channel current +TAOK1 TAO1 EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, STE; Protein kinase, Ser/Thr (non-receptor) Q7L7X3 57551 17q11.2 human T785-p 3627516 SINEMLStQALRLDE activity, induced cell cycle regulation 17396146 1 0 0 +CXCR4 CXCR4 GPCR, family 1; Membrane protein, integral; Membrane protein, multi-pass; Receptor, GPCR P61073 7852 2q22.1 human K333-ub 12324743 LKILSKGkRGGHSSV protein degradation 24489825 1 1 1 +Tbk1 TBK1 EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, Other; Protein kinase, Ser/Thr (non-receptor) Q9WUN2 56480 10|10 D2 mouse K670-ub 59149202 LAASGGVkHAMAPIY protein stabilization signaling pathway regulation 27692986 1 1 0 regulates IFN-1 signaling and antiviral innate immunity +Ap2m1 AP2M1 Adaptor/scaffold; Vesicle P84092 116563 11q23 rat T156-p 448782 SQITSQVtGQIGWRR molecular association, regulation; intracellular localization; protein conformation TGOLN2(INDUCES) 11516654; 15916959 9 33 29 T156A mutants are defective in the endocytosis of labelled transferrin. Although the paper demonstrates a functional correlation between T156 and endocytosis, it does not directly prove that this effect is due to phosphorylation.; increased binding to Yxx(hydrophobic) peptides such as TGOLN2 sorting signal (DYQRLN) and to phospholipids (PtdIns4,5P2-containing liposomes) +Tp63 p63 DNA-binding; Transcription factor O88898 22061 16 B1|16 17.37 cM mouse T567-p 20506701 SCLDYFTtQGLTTIY SAM_2 activity, induced 21325887 1 0 0 +IRS2 IRS2 Adaptor/scaffold; Motility/polarity/chemotaxis Q9Y4H2 8660 13q34 human Y675-p 454968 GSCRSDDyMPMSPAS molecular association, regulation PIK3C2A(INDUCES) 30459283 3 30 343 +SOX10 SOX10 Cell development/differentiation; DNA-binding; Transcription factor P56693 6663 22q13.1 human S24-p 7103084 SEEPRCLsPGSAPSL Sox_N protein stabilization cell differentiation, induced; transcription, induced; transcription, inhibited 29315345; 37481722 2 6 0 +SLBP SLBP RNA-binding Q14493 7884 4p16.3 human T61-p 466351 ERRPESFtTPEGPKP protein degradation; molecular association, regulation CUL4A(INDUCES); WDR23(INDUCES) 12588979; 18490441; 27254819 4 3 9 +DUSP3 DUSP3 EC 3.1.3.16; EC 3.1.3.48; Motility/polarity/chemotaxis; PHOSPHATASE; Protein phosphatase, dual-specificity P51452 1845 17q21.31 human Y138-p 448718 SPTLVIAyLMMRQKM DSPc enzymatic activity, induced 12447358 1 2 0 When ZAP-70 was reintroduced into the ZAP-70(-) JURKAT cells, DUSP3 regained its ability to inhibit MAPK responses. +ZFP36 TTP DNA-binding; RNA-binding P26651 7538 19q13.2 human S60-p 451150 RLPGRSTsLVEGRSC molecular association, regulation carcinogenesis, induced; RNA stability, induced RNA(INDUCES) 37210725 11 16 0 +CASP2 CASP2 Apoptosis; EC 3.4.22.55; Protease P42575 835 7q34 human S157-p 456810 LYKKLRLsTDTVEHS protein conformation; activity, inhibited 16193064 1 5 0 lack of phosphorylation of this residue leads to Casp's dimerization and activation +Cacng2 Stargazin Channel, calcium; Membrane protein, integral; Membrane protein, multi-pass O88602 12300 15 E1|15 36.92 cM mouse S253-p 455307 PSHSRDAsPVGVKGF activity, induced; intracellular localization 15664178; 20670832 3 7 0 AMPAR immobilization in synaptic membrane; enhances AMPA receptor responses and is required for long-term potentiation +Nf2 Merlin Cytoskeletal; Motility/polarity/chemotaxis; Tumor suppressor P46662 18016 11 A1|11 3.0 cM mouse S518-p 448282 DTDMKRLsMEIEKEK ERM_C cytoskeletal reorganization; cell growth, altered 20668201 33 41 1 neurite outgrowth +XRCC5 Ku80 DNA-binding; EC 3.6.1.-; EC 3.6.4.-; Helicase; Nuclear receptor co-regulator; Nucleolus; RNA-binding P13010 7520 2q35 human K443-ub 21177862 SSLKNSKkYAPTEAQ Ku molecular association, regulation DNA repair, induced DNA(DISRUPTS) 27895153 1 5 0 +EZH2 EZH2 iso2 EC 2.1.1.43; METHYLTRANSFERASE; Methyltransferase; Methyltransferase, protein lysine Q15910-2 2146 7q36.1 human S652-p 29606714 EYCGEIIsQDEADRR SET molecular association, regulation cell cycle regulation; DNA repair, induced SUZ12(DISRUPTS); EED(DISRUPTS) 24162653 1 0 0 +CDCA5 CDCA5 Cell cycle regulation Q96FF9 113130 11q13.1 human T151-p 28750703 RSYSRLEtLGSASTS Sororin activity, inhibited cell cycle regulation SCC-112(DISRUPTS) 23901111 1 2 0 +Pdx1 PDX1 DNA-binding; Transcription factor P52946 18609 5 G3|5 86.84 cM mouse T152-p 470134 EENKRTRtAYTRAQL Homeodomain intracellular localization 17052199 1 0 0 +PTK2 FAK EC 2.7.10.2; KINASE; Kinase, protein; Protein kinase, TK; Protein kinase, tyrosine (non-receptor) Q00944 396416 chicken Y577-p 447890 YMEDSTYyKASKGKL PK_Tyr_Ser-Thr activity, induced; phosphorylation; enzymatic activity, induced 12370821; 9790958 88 40 1747 +AHR AHR DNA-binding; Transcription factor P35869 196 7p21.1 human S689-p 1874101922 SQEFPYKsEMDSMPY protein degradation; ubiquitination autophagy, induced; transcription, induced 34198826 1 0 0 +MAP2K4 MKK4 EC 2.7.12.2; KINASE; Kinase, protein; Protein kinase, STE; Protein kinase, dual-specificity (non-receptor) P45985 6416 17p12 human K143-ub 11998603 TVDEKEQkQLLMDLD Pkinase protein degradation 19737936 1 0 0 +GTF2I GTF2I iso2 DNA-binding; Transcription, coactivator/corepressor P78347-2 2969 7q11.23 human Y462-p 448252 EAHPNDLyVEGLPEN GTF2I transcription, altered 11373296 1 3 2 +Tek TIE2 EC 2.7.10.1; KINASE; Kinase, protein; Membrane protein, integral; Protein kinase, TK; Protein kinase, tyrosine (receptor) Q02858 21687 4 C5|4 43.34 cM mouse Y1100-p 450256 MLEERKTyVNTTLYE molecular association, regulation transcription, altered GRB2(INDUCES); GRB7(INDUCES); SHP-2(INDUCES); GRB14(INDUCES); PIK3R1(INDUCES) 10521483; 11865050 5 0 0 +EGLN2 EGLN2 EC 1.14.11.29; Oxidoreductase Q96KS0 112398 19q13.2 human S234-p 4213802 QRAIPPRsIRGDQIA enzymatic activity, inhibited 18710826 1 0 0 +BCL2L1 Bcl-xL Apoptosis; Autophagy; Membrane protein, integral; Mitochondrial Q07817 598 20q11.21 human S145-p 1873647708 GRIVAFFsFGGALCV Bcl-2 protein stabilization; molecular association, regulation carcinogenesis, induced; apoptosis, inhibited RNF152(DISRUPTS) 34098062 1 0 0 inhibits ubiquitination +ABL1 Abl iso2 EC 2.7.10.2; KINASE; Kinase, protein; Oncoprotein; Protein kinase, TK; Protein kinase, tyrosine (non-receptor) P00519-2 25 9q34.12 human S69-p 461026 SEAARWNsKENLLAG protein conformation 16543148 1 2 18 role in autoinhibition of enzyme +TOB2 TOB2 Q14106 10766 22q13.2 human S254-p 14161520 PAPQSQLsPNAKEFV PAM2 molecular association, regulation cell growth, inhibited; RNA stability, inhibited CCR4(INDUCES); PABP 1(INDUCES); NOT1(INDUCES) 32404348 1 5 0 +CTNND1 CTNND1 Actin-binding; Adaptor/scaffold; Cell adhesion; G protein regulator, misc.; Motility/polarity/chemotaxis O60716 1500 11q12.1 human T916-p 450454 ERGDHNRtLDRSGDL carcinogenesis, induced; cell motility, induced; cell adhesion, inhibited 32589661 5 26 7 +JAK1 JAK1 EC 2.7.10.2; KINASE; Kinase, protein; Protein kinase, TK; Protein kinase, tyrosine (non-receptor) P23458 3716 1p31.3 human Y1035-p 448452 IETDKEYyTVKDDRD PK_Tyr_Ser-Thr enzymatic activity, induced carcinogenesis, induced; cell motility, induced 32029900; 34380633; 36166512 32 8 46 +PREX1 PREX1 GEF; GEF, Rac/Rho Q8TCU6 57580 20q13.13 human S605-p 18704702 DEEMEGTsSKNKQLR activity, induced 21042280; 27788493 2 0 0 +HABP4 HABP4 Transcription regulation Q5JVS0 22927 9q22.32 human T375-p 11380903 GRGARGGtRGGRGRI IHABP4_N molecular association, regulation; intracellular localization RACK1(DISRUPTS) 14699138 1 0 0 HABP4 associates with RACK1 in the nucleus but exits after activation with PMA +Adrb3 ADRB3 iso2 GPCR, family 1; Membrane protein, integral; Membrane protein, multi-pass; Receptor, GPCR P25962-2 11556 8 A2|8 15.94 cM mouse S389-p 456902 QSPPLNSsLLREPRH activity, induced 16144970 1 0 0 mutation of serines 388 and 389 to alanine abrogated cAMP accumulation in response to CL316243. +RAP1B RAP1B G protein; G protein, monomeric; G protein, monomeric, Ras P61223 327708 cow S180-p 22689703 GKARKKSsCQLL___ intracellular localization; activity, inhibited cell motility, induced RASSF5(DISRUPTS) 23946483 4 0 0 1) Cytosolic relocalization of Rap1 is phosphorylation dependent. 2) Rap1 phosphorylation is necessary for cell migration. 3) Binding of Rap1 to RapL is decreased by PKA-dependent phosphorylation of S180. +Gria1 GluR1 Channel, calcium; Channel, ligand-gated; Membrane protein, integral; Membrane protein, multi-pass P19490 50592 10q22 rat S836-p 467226 CYKSRSEsKRMKGFC activity, induced; intracellular localization signaling pathway regulation 16846856; 23511975 6 0 0 signaling for synaptic incorporation of AMPAR at activated synapses during LTP expression; promotes receptor incorporation into the synapse +SOS1 SOS1 Adaptor/scaffold; GEF; GEF, Ras; Motility/polarity/chemotaxis Q07889 6654 2p22.1 human S1132-p 451313 TLPHGPRsASVSSIS molecular association, regulation GRB2(DISRUPTS) 8816480 1 0 0 +CENPT CENPT DNA replication F1NPG5 chicken T72-p 3903606 FSELDNAtPRVMLRK CENP-T_N molecular association, regulation SPC25(INDUCES); SPBC24(INDUCES) 23334297 3 5 9 +MAP3K7 TAK1 EC 2.7.11.25; KINASE; Kinase, protein; Protein kinase, Ser/Thr (non-receptor); Protein kinase, TKL O43318 6885 6q15 human Y206-p 1869056901 EVFEGSNySEKCDVF PK_Tyr_Ser-Thr ubiquitination; phosphorylation 32403971 1 0 0 +SGK3 SGK3 EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, AGC; Protein kinase, Ser/Thr (non-receptor) Q96BR1 23678 8q13.1 human T320-p 448197 AISDTTTtFCGTPEY Pkinase phosphorylation; enzymatic activity, induced 31821448; 34181950 8 3 0 induces substrate phosphorylation; lost in SGK3 c.979-96TgtA variant +CASP9 CASP9 Apoptosis; EC 3.4.22.62; Protease P55211 842 1p36.21 human S183-p 448528 GLRTRTGsNIDCEKL Peptidase_C14 molecular association, regulation; enzymatic activity, inhibited; protein conformation APAF(DISRUPTS) 15703181; 29352269 2 0 0 forms higher order oligomers or aggregates, unfolds and disassembles the casp-9 core; inhibits the assembly of the apoptosome in response to cytochrome c +TNNI3 TNNI3 Actin-binding; Motility/polarity/chemotaxis; Motor P19429 7137 19q13.42 human T51-p 6796402 SRKLQLKtLLLQIAK Troponin molecular association, regulation; protein conformation C16orf82(INDUCES); TNC(INDUCES) 18986304 1 1 0 +TRPA1 TRPA1 Membrane protein, integral; Membrane protein, multi-pass O75762 8989 8q21.11 human T673-p 56672700 PLEFTKKtPTQDVIY activity, induced 27345869 1 0 0 +CDC25B CDC25B iso2 EC 3.1.3.48; Motility/polarity/chemotaxis; Nuclear receptor co-regulator; PHOSPHATASE; Protein phosphatase, dual-specificity P30305-2 994 20p13 human S309-p 448409 QRLFRSPsMPCSVIR M-inducer_phosp phosphorylation P38A(INDUCES) 17548358 13 9 30 phospho-p38 are Cdc25B S309-p are colocalized during prophase. +SIRT2 SIRT2 iso2 DEACETYLASE; Deacetylase; EC 3.5.1.- Q8IXJ6-2 22933 19q13.2 human K183-sm 1881502500 IFSEVTPkCEDCQSL enzymatic activity, inhibited carcinogenesis, inhibited 33316537 1 0 0 SIRT2 is the deacetylase of P38 and its enzyme activity is inhibited by its SUMOylation, SUMOylation inhibits the carcinogenic phenotype in neurblastoma cells and is a tumor suppressor in mice +IFNAR1 IFNAR1 Membrane protein, integral; Receptor, cytokine P17181 3454 21q22.11 human S532-p 11927800 KKYSSQTsQDSGNYS protein degradation; ubiquitination; activity, inhibited; phosphorylation apoptosis, inhibited; signaling pathway regulation 19948722; 21666722; 21695243; 28122987 5 0 0 regulation of PERK1 pathway; attenuation of INF alpha/beta signaling; induces phosphorylation at S535 +SLC6A4 SERT Membrane protein, integral; Membrane protein, multi-pass; Transporter P31645 6532 17q11.2 human T81-p 12610000 LHQGEREtWGKKVDF SNF protein conformation 20118234 1 0 0 +MVB12A FAM125A Adaptor/scaffold Q96EY5 93343 19p13.11 human T130-p 13211302 RLSGKTKtVPGYLRI DUF2464 protein processing 18005716 1 1 0 inhibition of HIV-1 release and infectivity +EIF4A2 EIF4A2 EC 3.6.4.13; Helicase; RNA-binding; Translation; Translation initiation Q14240 1974 3q27.3 human K226-sm 55610205 TDVLEVTkKFMRDPI intracellular localization 27160682 1 1 0 +FCER1G FCER1G Membrane protein, integral; Receptor, misc. P30273 2207 1q23.3 human S69-p 13310016 DGVYTGLsTRNQETY ITAM molecular association, regulation Syk(DISRUPTS) 27630214 1 8 0 +KAT7 MYST2 ACETYLTRANSFERASE; Acetyltransferase; EC 2.3.1.48; Nuclear receptor co-regulator; Transcription, coactivator/corepressor O95251 11143 17q21.33 human K576-ub 1877197200 KGKHLVLkRQDLIDE protein degradation 32555450 1 1 0 degraded during differentiation +CHEK2 Chk2 EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, CAMK; Protein kinase, Ser/Thr (non-receptor); Tumor suppressor O96017 11200 22q12.1 human S379-p 981401 SKILGETsLMRTLCG Pkinase ubiquitination; intracellular localization; enzymatic activity, induced apoptosis, induced 18644861; 20713355 4 12 1 +Rasgrp1 RASGRP1 GEF; GEF, Ras Q9Z1S3 19419 2 E5|2 59.19 cM mouse T184-p 456226 RDWSRKLtQRIKSNT carcinogenesis, induced 22116551 3 0 0 +Ptpn6 SHP-1 EC 3.1.3.48; Motility/polarity/chemotaxis; PHOSPHATASE; Protein phosphatase, tyrosine (non-receptor) P81718 116689 4q42 rat Y543-p 449656 SEYGNITyPPALRSA molecular association, regulation PIK3R1(INDUCES) 9452499 1 2 214 +Mnx1 MNX1 DNA-binding Q9QZW9 15285 5|5 B1 mouse S80-p 3191344 RLRAESPsPPRLLAA molecular association, regulation; intracellular localization cell motility, altered; transcription, inhibited NONO(INDUCES) DNA(INDUCES) 24425879; 26342078 2 17 1 nuclear localization; nuclear localization, inhibits Cbl-b transcription +CFTR CFTR Channel, chloride; EC 3.6.3.49; Hydrolase; Membrane protein, integral; Membrane protein, multi-pass; Transporter; Transporter, ABC family P13569 1080 7q31.2 human S700-p 449978 FGEKRKNsILNPINS CFTR_R molecular association, regulation; enzymatic activity, inhibited CFTR(INDUCES) 14602047 9 7 0 +CXCR4 CXCR4 GPCR, family 1; Membrane protein, integral; Membrane protein, multi-pass; Receptor, GPCR P61073 7852 2q22.1 human S339-p 458320 GKRGGHSsVSTESES activity, induced; receptor internalization, induced; intracellular localization cell growth, induced; cell growth, inhibited 19687226; 24632620; 26212080; 30327409 14 6 7 cytoplasmic localization; colony forming of cKit+ AML cells +Ntrk3 TrkC EC 2.7.10.1; KINASE; Kinase, protein; Membrane protein, integral; Protein kinase, TK; Protein kinase, tyrosine (receptor) Q03351 29613 1q31 rat Y516-p 450003 PVIENPQyFRQGHNC molecular association, regulation PLCG1(INDUCES); SHC1(INDUCES) 7657612 2 5 66 +Mlycd MLYCD Carbohydrate Metabolism - propanoate; EC 4.1.1.9; Lyase; Other Amino Acids Metabolism - beta-alanine Q99J39 56690 8|8 E1 mouse K471-ac 36957911 SISYLGSkNIKASEQ enzymatic activity, induced 23746352 1 2 0 regulates lipogenesis and FAO +FOXA2 FOXA2 DNA-binding; Transcription factor Q9Y261 3170 20p11.21 human K6-ac 33602701 __MLGAVkMEGHEPS protein stabilization transcription, induced 24875183 1 1 0 +PIN4 PIN4 EC 5.2.1.8; Isomerase; Mitochondrial; Nucleolus Q9Y237 5303 Xq13.1 human S19-p 3188102 AGKGGAAsGSDSADK molecular association, regulation; intracellular localization DNA(DISRUPTS) 12860119 1 0 0 +H3C1 H3 DNA-binding P68431 8350 6p22.2 human S57-p 481136 EIRRYQKsTELLIRK Histone DNA repair, altered; transcription, altered; cell growth, altered 20520775 2 19 9 +AMPH amphiphysin Vesicle P49418 273 7p14.1 human T445-p 10793310 EEPLAAVtPAVGLDL neural plasticity; apoptosis, inhibited 35858575 1 1 1 +Cebpb C/EBP-beta DNA-binding; Motility/polarity/chemotaxis; Transcription factor P28033 12608 2 H3|2 87.58 cM mouse S180-gl 7789200 SSGSLSTsSSSSPPG molecular association, regulation; phosphorylation cell differentiation, inhibited; transcription, inhibited DNA(DISRUPTS) 19478079 1 1 0 prevents phosphorylation of T179, S184, T188 +SOX2 SOX2 Cell development/differentiation; DNA-binding; Transcription factor P48431 6657 3q26.33 human Y277-p 27722639 LRDMISMyLPGAEVP protein stabilization; molecular association, regulation carcinogenesis, induced; autophagy, induced SQSTM1(DISRUPTS) 31823521 1 1 0 decrease ubiquitination and subsequent autophagic degradation +FYB1 SLAP-130 Adaptor/scaffold O15117 2533 5p13.1 human Y755-p 464285 CRNEEGKyGYVLRSY hSH3 cell motility, altered; cell adhesion, altered 20661443 1 4 185 promotes adhesion to ICAM-1; promotes cell migration +Kcnd2 Kv4.2 Channel, potassium; Membrane protein, integral; Membrane protein, multi-pass Q63881 rat T607-p 457612 IPTPPVTtPEGDDRP neural plasticity 35625355 7 0 0 +Tbc1d4 AS160 GAP; GAP, Rab Q8BYJ6 210789 14|14 E2.3 mouse S711-p 2226513 PSLHTSFsAPSFTAP phosphorylation 33872597 7 3 0 affects phosphorylation of other sites by AKT +Arrb2 ARRB2 Adaptor/scaffold Q91YI4 216869 11 B3|11 42.99 cM mouse S361-p 3176604 ITLPRPQsAPRETDV molecular association, regulation; receptor internalization, altered CLTC(DISRUPTS) 12186555 2 5 0 decreases beta2-adrenergic receptor internalization +MTSS1 MTSS1 Adaptor/scaffold; Motility/polarity/chemotaxis; Tumor suppressor O43312 9788 8q24.13 human S322-p 4763951 SSVSSHDsGFISQDA protein degradation; molecular association, regulation; ubiquitination cell motility, induced; cell growth, induced BTRC(INDUCES) 24318128 1 1 0 +Eif2ak3 PERK EC 2.7.11.1; KINASE; Kinase, protein; Membrane protein, integral; Protein kinase, Other; Protein kinase, Ser/Thr (non-receptor); Translation Q9Z2B5 13666 6|6 C1 mouse T799-p 11073906 YTRSREGtSSSIVFE molecular association, regulation; enzymatic activity, inhibited apoptosis, induced; apoptosis, inhibited Elf-2(DISRUPTS) 21954288; 32788341 3 0 1 Phosphorylation inactivates PERK, promoting proapoptotic effects of Akt.; PERK-elf2a sugnaling in neurodegenerative diseases +ZDHHC13 ZDHHC13 EC 2.3.1.225; Membrane protein, integral; Membrane protein, multi-pass; Transferase Q8IUH4 54503 11p15.1 human S208-p 1880741000 FLLKFNPsLNVVDKI molecular association, regulation; palmitoylation cell cycle regulation; DNA repair, induced; carcinogenesis, inhibited; transcription, induced; signaling pathway regulation MC1R(INDUCES) 36701140 1 1 0 induces MC1R-RHC downstream signaling +FANCA FANCA DNA repair, damage O15360 2175 16q24.3 human S165-p 56757905 HSMFSRLsFCQELWK ubiquitination; intracellular localization DNA repair, induced 27398318 1 0 0 nuclear foci formation +EEF2 EEF2 Translation; Translation elongation P13639 1938 19p13.3 human Y373-p 459352 KYRCELLyEGPPDDE sumoylation 24648518 1 2 44 induces sumoylation at K322 and K529 +GAB2 GAB2 Adaptor/scaffold Q9UQC2 9846 11q14.1 human Y266-p 448878 TEFRDSTyDLPRSLA molecular association, regulation CRKL(INDUCES) 11334882 1 13 228 +Myh14 MYH14 Motility/polarity/chemotaxis; Motor Q6URW6 71960 7|7 B3 mouse T1957-p 27623908 RRGPLTFtTRTVRQV cytoskeletal reorganization 23426373 1 0 0 Phosphorylation of either residue abolishes filament assembly of MYH14 Rod1296-1854. +RB1 Rb Nuclear receptor co-regulator; Oncoprotein; Transcription, coactivator/corepressor; Tumor suppressor P06400 5925 13q14.2 human S807-p 447980 PGGNIYIsPLKSPYK Rb_C molecular association, regulation; phosphorylation cell cycle regulation; carcinogenesis, induced; cell growth, induced; transcription, induced; transcription, altered; cell growth, altered ID2(DISRUPTS); E2F1(DISRUPTS); Abl iso2(DISRUPTS) 10969768; 15028555; 15619620; 16007177; 25698448; 32093423; 32094692; 33556114; 34108622; 34209868; 34247189; 34462276; 35194151; 35235778; 35437308; 36603130; 8626527; 9315635 102 45 112 +GRK2 GRK2 EC 2.7.11.15; KINASE; Kinase, protein; Protein kinase, AGC; Protein kinase, Ser/Thr (non-receptor) P21146 282682 cow Y86-p 447727 AKPLVEFyEEIKKYE RGS enzymatic activity, induced 18463167 5 0 0 +DES desmin Cytoskeletal; Motility/polarity/chemotaxis P17661 1674 2q35 human S12-p 449612 YSSSQRVsSYRRTFG Filament_head intracellular localization cytoskeletal reorganization 12686604 1 0 0 Mutated desmin sites showed failure of desmin filaments to segregate into daughter cells. ; Phosphorylated at the clevage furrow during cytokinesis. +MOB1A MOB1A Protein kinase, regulatory subunit Q9H8S9 55233 2p13.1 human K11-ac 9911535 LFSSRSSkTFKPKKN protein stabilization; molecular association, regulation; intracellular localization carcinogenesis, inhibited; transcription, inhibited; signaling pathway regulation LATS1(INDUCES) 35349706 1 0 1 MOB1 acetylation mediates oxidative stress regulation of the Hippo pathway, inhibits YAP/TAZ nuclear translocation, suppression of lung cancer cell proliferation, MOB1 acetylation inhibits migration, invasion in vitro and tumor growth in vivo +LSM4 LSM4 RNA-binding; Spliceosome Q9Y4Z0 25804 19p13.11 human R102-m2 15381281 QQKQQKGrGMGGAGR molecular association, regulation SMN(INDUCES) 11720283 1 1 3 +PHB2 BAP37 Mitochondrial; Nuclear receptor co-regulator; Transcription, coactivator/corepressor Q99623 11331 12p13.31 human K142-ub 573782384 SIVNEVLkSVVAKFN Band_7 molecular association, regulation; ubiquitination autophagy, induced LC3B(INDUCES) 36379251 1 1 0 BAP37 promotes ef?cient mitophagy +Pla2g4a PLA2G4A EC 3.1.1.4; EC 3.1.1.5; Lipid Metabolism - alpha-linolenic acid; Lipid Metabolism - arachidonic acid; Lipid Metabolism - ether lipid; Lipid Metabolism - glycerophospholipid; Lipid Metabolism - linoleic acid; Phospholipase P47713 18783 1 G1|1 63.51 cM mouse S505-p 447597 LNTSYPLsPLRDFSS PLA2_B enzymatic activity, induced 10978317; 8381049 25 6 8 +TCF3 E2A Cell development/differentiation; DNA-binding; Oncoprotein; Transcription factor P15923 6929 19p13.3 human S352-p 465681 SSNNFSSsPSTPVGS activity, inhibited transcription, inhibited 19801649 2 1 4 +Nlrp3 NLRP3 Inhibitor Q8R4B8 216799 11|11 B1.3 mouse S194-p 230295300 GRTKMRDsPMSSLKL FISNA protein stabilization; molecular association, regulation ABRAXAS2(INDUCES) 30787184 5 2 0 deubiquitination induced +LRP5 LRP5 Membrane protein, integral; Receptor, misc. O75197 4041 11q13.2 human T1492-p 23122924 SSSSTKAtLYPPILN enzymatic activity, induced 34205318 1 0 1 regulates HIF1A stability by inducing hydroxylation activity of PHD2 +PEAK1 PEAK1 EC 2.7.10.2; KINASE; Kinase, protein; Protein kinase, Other; Protein kinase, Ser/Thr (non-receptor) Q9H792 79834 15q24.3 human Y665-p 450418 TSVISHTyEEIETES intracellular localization cell motility, induced; cell adhesion, induced 23105102 1 4 26 Src activity is required for SgK269 localization to focal adhesions and SgK269 adhesion effects. +PAX3 PAX3 DNA-binding; Oncoprotein; Transcription factor P23760 5077 2q36.1 human K437-ac 25042100 SQRLDHMkSLDSLPT molecular association, regulation cell growth, inhibited; cell differentiation, induced; transcription, altered DNA(INDUCES) 21169561 1 0 0 K437 decreases Hes1 transcription, K437 and K475 increase transcription of Neurog2 +INCENP INCENP Cell cycle regulation; EC 2.7.11.1 Q9NQS7 3619 11q12.3 human S893-p 450467 PRYHKRTsSAVWNSP activity, induced; protein stabilization; molecular association, regulation; enzymatic activity, induced INCENP(INDUCES) 12925766; 27332895; 32028528 8 16 15 induces AurB activity +ULK1 ULK1 Autophagy; EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, Other; Protein kinase, Ser/Thr (non-receptor) O75385 8408 12q24.33 human S495-p 6220991 GVLARKMsLGGGRPY protein degradation; molecular association, regulation; ubiquitination; enzymatic activity, inhibited carcinogenesis, induced; cell growth, induced; apoptosis, inhibited; autophagy, inhibited ATG13(DISRUPTS); TRIM27(INDUCES); ATG101(DISRUPTS); RB1CC1(DISRUPTS) 31378785; 35670107 2 3 3 +TOB1 TOB1 Adaptor/scaffold; Cell cycle regulation P50616 10140 17q21.33 human S164-p 455537 FGHSAAVsPTFMPRS activity, inhibited cell cycle regulation; cell growth, inhibited; cell growth, altered 12050114; 12151396; 22252318 4 0 0 promote mRNA deadenylaion and decay and the ability to suppress proliferation; the antiproliferative activity of TOB1 is inhibited by phosphorylation.; the antiproliferative function of TOB1 is inhibited by phosphorylation. +Ep300 p300 ACETYLTRANSFERASE; Acetyltransferase; EC 2.3.1.48; Motility/polarity/chemotaxis; Nuclear receptor co-regulator; Transcription, coactivator/corepressor B2RWS6 328572 15|15 E1 mouse S1833-p 447591 MLRRRMAsMQRTGVA molecular association, regulation cell differentiation, induced MyoD(INDUCES) 17964260 9 0 0 Muscle differentiation +DNMT1 DNMT1 Amino Acid Metabolism - cysteine and methionine; Cell development/differentiation; EC 2.1.1.37; METHYLTRANSFERASE; Methyltransferase; Methyltransferase, DNA; Transcription regulation P26358 1786 19p13.2 human K1115-ac 466146 NKGKGKGkGKGKPKS cell cycle regulation; transcription, inhibited 21947282 1 4 10 +RPL11 RPL11 Motility/polarity/chemotaxis; Nucleolus; Ribosomal; Translation P62913 6135 1p36.11 human K67-ne 12067602 FGIRRNEkIAVHCTV Ribosomal_L5_C protein stabilization; intracellular localization 19713960 1 0 0 +CDC34 CDC34 EC 6.3.2.19; Ligase; UBIQUITIN LIGASE; Ubiquitin conjugating system; Ubiquitin ligase P49427 997 19p13.3 human T162-p 59049803 KGKDREYtDIIRKQV UQ_con protein degradation; ubiquitination 27786305 1 0 0 +CBLB Cbl-b Adaptor/scaffold; Calcium-binding; EC 6.3.2.-; Ligase; UBIQUITIN LIGASE; Ubiquitin conjugating system; Ubiquitin ligase Q13191 868 3q13.11 human Y106-p 5641270 AQLSENEyFKIYIDS Cbl_N ubiquitination; enzymatic activity, induced 26416283 1 0 2 +Wasf2 WAVE2 Actin-binding; Motility/polarity/chemotaxis Q8BH43 242687 4 D2.3|4 66.22 cM mouse T470-p 56675609 VVGNDVAtILSRRIA protein stabilization 29760073 1 1 0 induces phagocytosis +PDE3B PDE3B EC 3.1.4.17; Membrane protein, integral; Membrane protein, multi-pass; Nucleotide Metabolism - purine; Phosphodiesterase Q13370 5140 11p15.2 human S295-p 447699 VIRPRRRsSCVSLGE enzymatic activity, induced 26031333 4 7 78 activation by insulin +Cited1 CITED1 Nuclear receptor co-regulator P97769 12705 X D|X 45.25 cM mouse S63-p 27937114 KANGVPTsSSGSTSP CITED intracellular localization cell differentiation, induced 23529225 1 0 0 S63/64/65/67/69/73/79/80/84A mutation in CITED1 inhibits its translocation into the nucleus and osteoblasts differentiation +MARCKS MARCKS Actin-binding; Motility/polarity/chemotaxis P29966 4082 6q21 human S170-p 451837 SFKLSGFsFKKNKKE MARCKS exocytosis, inhibited 21762971 11 76 93 induce MUC5AC secretion by cold +Vav3 VAV3 Actin-binding; Adaptor/scaffold; GEF; GEF, Rac/Rho; Motility/polarity/chemotaxis; Nuclear receptor co-regulator Q9R0C8 57257 3|3 F3 mouse Y141-p 4834228 SINDEDIyKGLPDLI cell cycle regulation; cell motility, altered 18515860 0 2 4 +BANF1 BAF DNA-binding O75531 8815 11q13.1 human T2-p 7105310 ______MtTSQKHRD BAF molecular association, regulation; intracellular localization DNA(INDUCES); DNA(DISRUPTS) 16495336; 24600006; 24945635 3 7 0 higher level of viral proteins after infection, AAA mutant inhibits viral protein levels; ser4 phosphorylation alone is sufficient to inhibit DNA binding. Both hyperphosphorylated and unphosphorylated mutants cannot suppress vaccinia DNA replication and its yield +RAF1 RAF1 EC 2.7.11.1; KINASE; Kinase, protein; Oncoprotein; Protein kinase, Ser/Thr (non-receptor); Protein kinase, TKL P04049 5894 3p25.2 human S296-p 455218 SPSALSSsPNNLSPT molecular association, regulation; intracellular localization; enzymatic activity, inhibited; enzymatic activity, induced HRas(DISRUPTS) 15642359; 15664191; 16407412 5 25 46 phosphorylation of S289, S296, and S301 sustains and increases kinase activity +CDKN1A p21Cip1 Cell cycle regulation; Inhibitor P38936 1026 6p21.2 human K163-ac 12615904 RLIFSKRkP______ protein stabilization; molecular association, regulation cell cycle regulation; carcinogenesis, inhibited; cell growth, inhibited C8A(DISRUPTS) 20154723; 23238566 2 1 0 induces senescence and DNA-damage-induced cell cycle arrest +Nr4a3 NR4A3 DNA-binding; Nuclear receptor; Oncoprotein Q9QZB6 18124 4|4 B1 mouse K137-sm 1874485102 PSTSMYFkQSPPSTP protein stabilization; molecular association, regulation; acetylation; activity, inhibited cell growth, inhibited; apoptosis, induced; transcription, inhibited DNA(DISRUPTS) 34383980 1 0 0 inhibits H3 acetylation +NADK2 NADK2 EC 2.7.1.23 Q4G0N4 133686 5p13.2 human S188-p 485700 VNTDPERsEGHLCLP NAD_kinase enzymatic activity, inhibited; enzymatic activity, induced 26577408; 35868311 2 11 0 K76Q and K304Q mutants reduced proline production, K76Q and K304Q mutants and S116A showed reduced catalytic activity, phosphorylation, succinylation, or acetylation could generate a charge repulsion in the active site +APP APP Apoptosis; Cell surface; Membrane protein, integral; Receptor, misc.; Transcription factor P05067 351 21q21.3 human K725-ne 12124803 ITLVMLKkKQYTSIH APP_amyloid transcription, inhibited Fe65(DISRUPTS) 18096514 1 0 0 +Ric8a RIC8A GEF; GEF, misc. NP_001093990 293614 1q41 rat S527-p 3213327 QLSSDPDsDPD____ molecular association, regulation G-alpha i1(INDUCES) 29844055 1 6 0 G-alpha subunit guanine nucleotide exchange; G-alpha subunit folding +Slc12a5 KCC2 iso2 Membrane protein, integral; Membrane protein, multi-pass; Transporter; Transporter, SLC family Q63633-2 171373 3q42 rat S940-p 487533 ITDESRGsIRRKNPA SLC12 activity, induced neural plasticity 31969605 23 5 2 +AKT1 Akt1 EC 2.7.11.1; KINASE; Kinase, protein; Oncoprotein; Protein kinase, AGC; Protein kinase, Ser/Thr (non-receptor) P31749 207 14q32.33 human T479-p 8086741 FSYSASGtA______ molecular association, regulation; phosphorylation; enzymatic activity, induced cell cycle regulation; carcinogenesis, induced; cell growth, induced; apoptosis, inhibited Sin1(INDUCES) 24670654 2 4 12 primed for phosphorylation of S473 +ELMO1 ELMO1 Cytoskeletal; Motility/polarity/chemotaxis Q92556 9844 7p14.2-p14.1 human Y395-p 455874 AKHHQDAyIRIVLEN ELMO_CED12 molecular association, regulation; intracellular localization NCK1(INDUCES); RHOG(INDUCES) 24928514 3 2 0 Nck1 enhances ELMO1 and RhoG interaction and promotes Rac1 activity; localization of ELMO1 to the plasma membrane +Oprm1 MOR-1 GPCR, family 1; Membrane protein, integral; Membrane protein, multi-pass; Receptor, GPCR P42866 18390 10 A1|10 1.85 cM mouse T379-p 20727900 EHPSTANtVDRTNHQ receptor desensitization, induced; receptor internalization, induced; molecular association, regulation endocytosis, induced; signaling pathway regulation ARRB2(INDUCES) 21868358; 23239825; 30018083; 32234959 7 2 0 regulates B-arrestin signaling +NFATC3 NFAT4 DNA-binding; Transcription factor Q12968 4775 16q22.1 human T210-p 11507603 FTLGSPLtSPGGSPG intracellular localization 9630228 1 0 0 cytoplasmic localization (inhibition of nuclear localization) +ERG ERG DNA-binding; Oncoprotein; Transcription factor P11308 2078 21q22.2 human Y183-p 1870421702 FQRLTPSyNADILLS SAM_PNT protein degradation; molecular association, regulation; ubiquitination; phosphorylation carcinogenesis, inhibited; cell growth, inhibited; transcription, inhibited FBXW7(INDUCES) 32871104 1 0 0 +EPHB4 EphB4 EC 2.7.10.1; KINASE; Kinase, protein; Membrane protein, integral; Protein kinase, TK; Protein kinase, tyrosine (receptor) P54760 2050 7q22.1 human Y987-p 451663 TGGPAPQy_______ protein stabilization; protein conformation carcinogenesis, induced 31270394 1 16 347 inhibits ubiquitination +MECP2 MECP2 Transcription, coactivator/corepressor P51608 4204 Xq28 human S423-p 470075 EKMPRGGsLESDGCP neural plasticity 35767654 15 13 0 +PRC1 PRC1 Cell cycle regulation; Cytoskeletal; Microtubule-binding; Motility/polarity/chemotaxis O43663 9055 15q26.1 human T578-p 26331400 SINSVAStYSEFAKD phosphorylation 17351640 1 0 0 Docking site phosphorylation at T616 is regulated T578 phosphorylation. +CLIP1 Restin Cytoskeletal P30622 6249 12q24.31 human S312-p 4769833 ASLKRSPsASSLSSM molecular association, regulation cytoskeletal reorganization TUBA1B(DISRUPTS) 24451569 4 13 1 phosphorylated during mitosis, impairs microtubule (MT) nucleation/polymerization end-tracking in vitro, necessary for kinetichore MT attachment and chromosome alignment +ATP5F1A ATP5A1 EC 3.6.3.14; Energy Metabolism - oxidative phosphorylation; Hydrolase; Membrane protein, integral; Mitochondrial; Transporter P25705 498 18q21.1 human K531-ac 466473 GTIRADGkISEQSDA ATP-synt_ab_C cell growth, inhibited 32002124 1 6 58 tumor growth inhibited (increased in K506/531R mutant) +PRKCD PKCD EC 2.7.11.13; KINASE; Kinase, protein; Nuclear receptor co-regulator; Protein kinase, AGC; Protein kinase, Ser/Thr (non-receptor); Protein kinase, tyrosine (non-receptor); Tumor suppressor Q05655 5580 3p21.1 human Y187-p 447579 WGLNKQGyKCRQCNA C1_1 activity, inhibited; phosphorylation apoptosis, altered; apoptosis, induced 11927579; 18434324 6 0 0 ERK phosphorylation/activation +Cebpb C/EBP-beta DNA-binding; Motility/polarity/chemotaxis; Transcription factor P21272 24253 3q42 rat R114-m1 13373505 YGYVSLGrAGAKAAP molecular association, regulation cell growth, induced; transcription, induced DNA(INDUCES) 20351173 0 1 0 +Ripk1 RIPK1 EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, Ser/Thr (non-receptor); Protein kinase, TKL Q60855 19766 13 A3.3|13 14.01 cM mouse S166-p 27116401 VASFKTWsKLTKEKD PK_Tyr_Ser-Thr molecular association, regulation; enzymatic activity, induced carcinogenesis, inhibited; apoptosis, induced; transcription, induced; signaling pathway regulation TNF-R1(INDUCES) 28701375; 32094226; 32366830; 33914027; 34665642; 34990405; 35430614 36 2 0 +Dcx Doublecortin Cytoskeletal; Motility/polarity/chemotaxis O88809 13193 X|X F2 mouse Y125-p 1833062501 ELEEGESyVCSSDNF DCX protein stabilization cytoskeletal reorganization 31914386 1 0 0 +Sphk1 SPHK1 ACETYLTRANSFERASE; Acetyltransferase; EC 2.3.1.-; EC 2.7.1.91; Kinase, lipid; Lipid Metabolism - sphingolipid Q8CI15 20698 11|11 E2 mouse S225-p 460682 VASKRPAsTLVQKGP intracellular localization; protein conformation; enzymatic activity, induced 19729605; 33865856 14 8 0 +Abcc9 ABCC9 Channel, potassium; Membrane protein, integral; Membrane protein, multi-pass; Transporter; Transporter, ABC family P70170 20928 6 G2|6 74.35 cM mouse S1465-p 483975 RAFVRKSsILIMDEA ABC_tran activity, induced 15087422 2 0 0 +FOXO3 FOXO3A Autophagy; DNA-binding; Oncoprotein; Transcription factor O43524 2309 6q21 human S253-p 449108 APRRRAVsMDNSNKY activity, induced; molecular association, regulation; intracellular localization; activity, inhibited; phosphorylation cell cycle regulation; carcinogenesis, induced; apoptosis, altered; carcinogenesis, inhibited; cell motility, induced; transcription, altered; autophagy, induced; cell growth, induced; apoptosis, inhibited; autophagy, inhibited; transcription, inhibited 14-3-3 beta(INDUCES); 14-3-3 zeta(INDUCES); 14-3-3 epsilon(INDUCES) 10102273; 11154281; 17079231; 18593906; 18794113; 20110348; 21777391; 21980390; 25745998; 26376801; 32005974; 34421352; 34475505; 35077510; 35874228 37 19 76 +PSRC1 PSRC1 Q6PGN9 84722 1p13.3 human S70-p 472052 RLSLGPLsPEKLEEI GTSE1_N cytoskeletal reorganization 21473853 1 21 10 +Pawr PAR-4 Apoptosis Q62627 64513 7q21 rat S249-p 456965 SRHNRDTsAPANFAS ATG16; DUF724; DUF4164 intracellular localization apoptosis, inhibited 16209943 1 0 0 phosphorylation by Akt prevents apoptosis +DAPK3 DAPK3 EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, CAMK; Protein kinase, Ser/Thr (non-receptor); Tumor suppressor O43293 1613 19p13.3 human T299-p 454893 PERRRLKtTRLKEYT intracellular localization 15611134; 20854903 3 0 0 +SRPK2 SRPK2 EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, CMGC; Protein kinase, Ser/Thr (non-receptor) P78362 6733 7q22.3 human T492-p 483237 PSHDRSRtVSASSTG molecular association, regulation; intracellular localization; enzymatic activity, induced cell cycle regulation; transcription, altered 14-3-3 beta(INDUCES); 14-3-3 epsilon(INDUCES) 19592491 3 6 0 nuclear translocation of SRPK2 is blocked by 14-3-3 +MAVS MAVS Adaptor/scaffold; Membrane protein, integral Q7Z434 57506 20p13 human K7-sc 33344549 _MPFAEDkTYKYICR CARD_2 activity, induced 32301534 1 2 0 cellular antiviral response +SLC39A7 SLC39A7 Membrane protein, integral; Membrane protein, multi-pass; Transporter; Transporter, SLC family Q92504 7922 6p21.32 human S293-p 18015864 VQKRRGGsTVPKDGP Zip activity, induced; phosphorylation exocytosis, induced; signaling pathway regulation 28205653 1 3 0 maximal activation, SLC39A7 and Akt activation, zinc release and downstream effectors GSK3B, and p70 S6, phosphorylation of multiple kinases +TBK1 TBK1 EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, Other; Protein kinase, Ser/Thr (non-receptor) Q9UHD2 29110 12q14.2 human R54-me 1881361501 RPVDVQMrEFEVLKK enzymatic activity, induced 34551290 1 0 0 TBK1 aggregation, PRMT1 positively regulates antiviral immune responses, and promotes cellular innate antiviral signaling +ESR1 ER-alpha DNA-binding; Nuclear receptor; Transcription factor P03372 2099 6q25.1-q25.2 human K180-sm 27992519 SMAMESAkETRYCAV Oest_recep transcription, inhibited 22826433 1 1 0 ER-alpha SUMOylation suppresses ER transcriptional activation by full antiestrogens (AEs) in the absence of induced ER degradation +WRN WRN Cell cycle regulation; DNA repair, damage; DNA-binding; EC 3.6.4.12; Helicase; Nucleolus Q14191 7486 8p12 human K1389-ac 486390 CSSSKRSkEEVGINT protein stabilization; ubiquitination 20428248 1 1 0 inhibits ubiquitination +PEBP1 RKIP Lipid-binding; Protein kinase, regulatory subunit P30086 5037 12q24.23 human S109-p 59070500 VLSDYVGsGPPKGTG PBP molecular association, regulation TBK1(INDUCES) 27753621 2 0 0 +PTGES3 TEBP Chaperone; EC 5.3.99.3; Isomerase; Nuclear receptor co-regulator; Transferase Q15185 10728 12q13.3|12 human S113-p 451129 WKDWEDDsDEDMSNF molecular association, regulation; enzymatic activity, induced HSP90A(INDUCES); CK2A1(INDUCES) 15040786 3 111 391 +CASR CaR GPCR, family 3; Membrane protein, integral; Membrane protein, multi-pass; Motility/polarity/chemotaxis; Receptor, GPCR P41180 846 3q13.33-q21.1 human S915-p 11488700 STPSSSIsSKSNSED activity, induced 9694886 1 0 0 +ETFB ETFB Mitochondrial; Oxidoreductase P38117 2109 19q13.41 human K203-m3 36974100 PNIMKAKkKKIEVIK ETF enzymatic activity, inhibited 25416781 2 2 0 inhibitory effect on the transfer of electrons +PAK2 PAK2 EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, STE; Protein kinase, Ser/Thr (non-receptor) Q13177 5062 3q29 human Y130-p 448301 VLDVLKFyDSNTVKQ PBD enzymatic activity, induced 12215529; 29987050 2 1 137 Y130F mutant failed to rescue PAK2 function-role in SFK-mediated phosphorylation +RBBP8 CtIP EC 3.1.-.-; Transcription, coactivator/corepressor Q99708 5932 18q11.2 human K426-ub 1883319600 QNRTEYGkDSNTDKH phosphorylation DNA repair, inhibited 36092721 1 1 0 suppresses HR and DNA resection, ubiquitylation is inhibited by phosphorylation by PLK1 +Ppp1r1b DARPP-32 Motility/polarity/chemotaxis; Protein phosphatase, regulatory subunit Q6J4I0 360616 10q31 rat S102-p 457675 NLSENQAsEEEDELG DARPP-32 protein conformation 8226946 8 13 23 PKA phosphorylation did not alter fluorescence parameters, and only minor effects were associated with casein kinase II +PCYT1A PCYT1A EC 2.7.7.15; Lipid Metabolism - glycerophospholipid; Transferase P49585 5130 3q29 human S362-p 451335 KAAAYDIsEDEED__ intracellular localization 32186954 3 49 57 +Ncor1 N-CoR1 Nuclear receptor co-regulator; Transcription, coactivator/corepressor Q60974 20185 11|11 B2 mouse K152-sm 3755600 KDPAFGVkHEAPSSP GPS2_interact transcription, inhibited 16421255 1 0 0 +CERT1 COL4A3BP EC 2.7.11.9; KINASE; Kinase, protein; Lipid-binding; Protein kinase, Ser/Thr (non-receptor); Protein kinase, atypical Q9Y5P4 10087 5q13.3 human S315-p 25174303 DYEEGPNsLINEEEF activity, induced; molecular association, regulation; intracellular localization chromatin organization, altered VAPA(INDUCES) 24569996; 35409383 2 2 0 enhances interaction, ER to Golgi transport of ceramide, punctate structures +NFKB1 NFkB-p105 iso2 DNA-binding; Transcription factor P19838-2 4790 4q24 human Y60-p 465351 QRGFRFRyVCEGPSH RHD_DNA_bind protein stabilization; molecular association, regulation transcription, altered DNA(INDUCES) 36534507 1 1 1 +TUBA1C TUBA1C Cytoskeletal; Motility/polarity/chemotaxis Q9BQE3 84790 12q13.12 human K40-ac 479499 DGQMPSDkTIGGGDD Tubulin cytoskeletal reorganization 23071314 1 2 15 +Nr3c1 GR DNA-binding; Mitochondrial; Nuclear receptor; Transcription factor P06536 24413 18p11 rat K721-sm 31089514 ELGKAIVkREGNSSQ Hormone_recep transcription, induced 23508108 1 1 0 +KLF5 KLF5 C2H2-type zinc finger protein; DNA-binding; Transcription factor Q13887 688 13q22.1 human S303-p 14652801 QATYFPPsPPSSEPG protein degradation; molecular association, regulation; ubiquitination carcinogenesis, altered; transcription, inhibited FBXW7(INDUCES) 20484041; 24398687 2 0 0 +PPP1R12A MYPT1 Motility/polarity/chemotaxis; PHOSPHATASE; Protein phosphatase, regulatory subunit O14974 4659 12q21.2-q21.31 human K442-m1 1872438900 TWRLGLRkTGSYGAL protein stabilization 21115810 1 0 0 +SOX10 SOX10 Cell development/differentiation; DNA-binding; Transcription factor P56693 6663 22q13.1 human T240-p 56655880 GQSHGPPtPPTTPKT sumoylation; protein stabilization; molecular association, regulation; activity, inhibited transcription, inhibited UBC9(DISRUPTS) 29295999; 29315345 2 3 0 pMITF expression; inhibits sumoylation +CERS6 LASS6 DNA-binding; Membrane protein, integral; Membrane protein, multi-pass Q6ZMG9 253782 2q24.3 human S345-p 22350306 DDRSDIEsSSDEEDS enzymatic activity, induced 26887952 1 3 0 +KIF2A KIF2A Microtubule-binding; Motor O00139 3796 5q12.1 human S135-p 4705535 SSAQQNGsVSDISPV intracellular localization; activity, inhibited cytoskeletal reorganization; cell motility, inhibited 26323690 1 5 0 decreases MT-binding and depolymerizing activity of KIF2A +HNRNPUL1 E1B-AP5 RNA splicing; RNA-binding Q9BUJ2 11100 19q13.2 human R620-m2 9481295 GGGGFRGrGGGGGFQ molecular association, regulation; intracellular localization NBS1(INDUCES) 26020839 1 3 1 ecruitment at sites of damage +Map2 MAP2 Cytoskeletal; Motility/polarity/chemotaxis P15146 25595 9q32 rat T1625-p 450182 RTPGTPGtPSYPRTP molecular association, regulation cytoskeletal reorganization 25309320 3 19 17 fractionated with microtubules, protrusion growth, regulates basal dendrite architecture in vivo +Klf4 KLF4 C2H2-type zinc finger protein; DNA-binding; Transcription factor Q60793 16600 4 B3|4 29.76 cM mouse R396-m2 1881871201 RRSWPRKrTATHTCD transcription, inhibited 35137179 1 1 0 restrain the PrE commitment in mouse blastocysts +GLI3 GLI3 C2H2-type zinc finger protein; Transcription factor P10071 2737 7p14.1 human S877-p 15501382 CFSSRRSsEASQAEG protein processing transcription, inhibited 10693759 1 0 3 +KIF23 KIF23 Microtubule-binding; Motility/polarity/chemotaxis; Motor Q02241 9493 15q23 human S911-p 459840 NGSRKRRsSTVAPAQ intracellular localization cytoskeletal reorganization 16461284; 23940115 5 18 267 +App APP iso2 Apoptosis; Cell surface; Membrane protein, integral; Receptor, misc.; Transcription factor P12023-2 11820 16 C3.3|16 46.92 cM mouse T668-p 448523 VEVDAAVtPEERHLS APP_amyloid molecular association, regulation; intracellular localization Fe65(DISRUPTS); PIN1(INDUCES); 14-3-3 gamma(DISRUPTS) 16223726; 16716194; 27325702 39 5 3 +CSNK2A1 CK2A1 EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, Other; Protein kinase, Ser/Thr (non-receptor) P68400 1457 20p13 human T13-p 31012808 PSRARVYtDVNTHRP transcription, induced 24297901 1 1 1 rRNA synthesis induced +Khdrbs1 KHDRBS1 RNA-binding Q60749 20218 4|4 D2.2 mouse S58-p 449876 PRGGARAsPATQPPP activity, induced translation, altered 12478298 1 14 0 regulates splicing +AGO2 AGO2 EC 3.1.26.n2; RNA processing; RNA-binding Q9UKV8 27161 8q24.3 human T830-p 62849200 DSAEGSHtSGQSNGR molecular association, regulation; activity, inhibited transcription, inhibited RNA(DISRUPTS) 28114302 2 2 0 regulates miRNA silencing +SKIL SKIL Cell development/differentiation; Transcription, coactivator/corepressor P12757 6498 3q26.2 human K449-ub 3144806 HSSGKLQkTVSYPDV protein degradation signaling pathway regulation 11691834 1 1 0 TGF-beta signaling +Slc23a2 SLC23A2 Membrane protein, integral; Membrane protein, multi-pass; Transporter; Transporter, SLC family Q9EPR4 54338 2|2 F2 mouse S403-p 483979 YYACARLsCAPPPPI Xan_ur_permease intracellular localization cell differentiation, altered 17585336 1 0 0 Phosphorylation is required for SLC3A2 localization in plasma membrane, and ascorbic acid uptake. +Pex5l PEX5L Unknown function Q925N3 286937 2q24 rat S237-p 481412 ALLSRNHsLEEEFER activity, induced; protein stabilization; molecular association, regulation; intracellular localization HCN1(INDUCES); CNBD1(INDUCES) 31492750 1 16 11 Regulates HCN channel function; interaction of PEX5L with HCN1-CNBD region +Kcnd2 Kv4.2 Channel, potassium; Membrane protein, integral; Membrane protein, multi-pass Q63881 rat S438-p 2906103 ARIRAAKsGSANAYM protein stabilization neural plasticity 15071113; 35625355 4 0 1 +LTF LTF EC 3.4.21.-; Protease; Secreted; Secreted, signal peptide P02788 4057 3p21.31 human S54-p 1883890600 KVRGPPVsCIKRDSP protein degradation transcription, induced 20404350 1 0 0 +SHC3 SHC3 iso2 Adaptor/scaffold; Motility/polarity/chemotaxis Q92529-2 53358 9q22.1 human Y219-p 451258 DGSDHPYyNSIPSKM molecular association, regulation CRK(INDUCES); RAPGEF1(INDUCES) 11791173 3 3 8 +DOCK6 DOCK6 GEF; GEF, misc.; Motility/polarity/chemotaxis Q96HP0 57572 19p13.2 human S1194-p 27806316 GQRSRLAsMLDSDTE enzymatic activity, inhibited cell growth, inhibited 23462102 1 2 0 +P2RY2 P2Y2 GPCR, family 1; Membrane protein, integral; Membrane protein, multi-pass; Receptor, GPCR; Receptor, misc. P41231 5029 11q13.4 human S356-p 2909202 IEDVLGSsEDSRRTE receptor desensitization, altered; intracellular localization 16311903 2 0 0 +TRAF2 TRAF2 Autophagy; EC 6.3.2.-; Ligase; UBIQUITIN LIGASE; Ubiquitin conjugating system; Ubiquitin ligase Q12933 7186 9q34.3 human S55-p 7378202 QCGHRYCsFCLASIL zf-C3HC4 apoptosis, inhibited; transcription, altered 19336568; 28726782 2 0 0 promotes NF-?B activation but suppresses c-Jun activation under H/R conditions; protects cells from stress-induced apoptosis +NPHS1 NPHS1 Cell adhesion; Immunoglobulin superfamily; Membrane protein, integral O60500 4868 19q13.12 human T1120-p 18507016 EYEESQWtGERDTQS molecular association, regulation ARRB2(INDUCES) 21321125 2 0 0 PICK1 and PKCa are also in this complex +Osbpl3 OSBPL3 iso3 Endoplasmic reticulum D3Z194 71720 6|6 B2.3 mouse T248-p 6209017 SMDVLHRtYSAPAIN apoptosis, inhibited 31509750 1 2 1 inhibits insulin secretion +KNG1 KNG1 Cell adhesion; Contractile; Inhibitor; Motility/polarity/chemotaxis; Secreted; Secreted, signal peptide P01042 3827 3q27.3 human S390-p 5024714 PGFSPFRsSRIGEIK protein processing 18844446 1 0 0 inhibits cleavage by kallikrein in vitro +SERPINA3 SERPINA3 Secreted; Secreted, signal peptide P01011 12 14q32.13 human K237-ac 464674 RFYLSKKkWVMVPMM Serpin molecular association, regulation DNA(INDUCES) 7782318 1 0 0 +Ripk3 RIPK3 EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, Ser/Thr (non-receptor); Protein kinase, TKL Q9QZL0 56532 14|14 C3 mouse K359-ub 1883588009 PSGPVPGkCPERQAQ apoptosis, inhibited 35800780 1 1 0 Loss of RIPK3-K359 ubiquitin modification prevents increased RIPK3-K469R killing activity, RIPK3-K469ub can restrict cell death by preventing upstream ubiquitylation on K359 +ATP4A ATP4A EC 3.6.3.10; Energy Metabolism - oxidative phosphorylation; Hydrolase; Membrane protein, integral; Membrane protein, multi-pass; Transporter; Transporter, ion channel P20648 495 19q13.12 human Y10-p 484290 KAENYELySVELGPG H-K_ATPase_N protein conformation 12480547 3 0 15 Structure indicates tyrosine sequential phosphorylation at Y10 and subsequent Y7 which may induce activation of ATP4A. +SF1 SF1 RNA splicing; RNA-binding; Spliceosome; Transcription, coactivator/corepressor Q15637 7536 11q13.1 human S82-p 452435 NPEDRSPsPEPIYNS SF1-HH molecular association, regulation RNA splicing, altered U2AF2(INDUCES) 16420481 1 88 12 facilitates formation of the SF1-U2AF-RNA complex +Twist1 TWIST1 Cell development/differentiation; DNA-binding; Inhibitor; Transcription regulation P26687 22160 12 A3|12 14.81 cM mouse T125-p 38546302 NVRERQRtQSLNEAF HLH carcinogenesis, induced; cell motility, induced; cell growth, induced 25622896; 32922123 4 0 0 +Gphn gephyrin Adaptor/scaffold; EC 2.10.1.1; EC 2.7.7.75 Q8BUV3 268566 12|12 C3 mouse S270-p 2020113 LSTTPSEsPRAQATS activity, induced; receptor internalization, induced; protein degradation; ubiquitination; intracellular localization neural plasticity 21173228; 31080408; 33878252; 35245123 10 23 2 induces GABAAR internalization +Rbm38 RBM38 RNA-binding Q62176 56190 2|2 H3 mouse S193-p 29606707 DQYPYAAsPAAATSF cell cycle regulation; carcinogenesis, induced; translation, induced 30567739; 33664057 7 0 0 regulates cellular senescence in a p53-dependent manner; induces p63 mRNA stability +CDK16 CDK16 Cell cycle regulation; EC 2.7.11.22; KINASE; Kinase, protein; Motility/polarity/chemotaxis; Protein kinase, CMGC; Protein kinase, Ser/Thr (non-receptor) Q00536 5127 Xp11.3 human S12-p 453448 KKIKRQLsMTLRGGR exocytosis, inhibited 22798068 2 18 12 BRSK2 phosphorylation inhibited insulin secretion at 25 mM glucose. +Junb JunB Motility/polarity/chemotaxis; Oncoprotein; Transcription factor P24898 24517 19q11 rat T150-p 1814004 LHKMNHVtPPNVSLG Jun protein degradation cell cycle regulation; transcription, altered 10790372 1 0 0 Phosphorylation promoted degradation during the G2-M transition. JunB inhibition of cyclin D1 transcription is relieved by JunB protein degradation. +Mknk2 Mnk2 EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, CAMK; Protein kinase, Ser/Thr (non-receptor); Translation Q8CDB0 17347 10|10 C1 mouse T244-p 447640 GDCSPIStPELLTPC Pkinase enzymatic activity, induced 11154262 1 1 0 +GJA1 GJA1 Channel, misc.; Membrane protein, integral; Membrane protein, multi-pass; Motility/polarity/chemotaxis Q6TYA7 rabbit S369-p 459208 RPSSRASsRASSRPR intracellular localization 18574580 15 8 2 ischemia induces changes in the pattern of the Cx43 membrane distribution +Irs1 IRS1 Adaptor/scaffold; Motility/polarity/chemotaxis P35570 25467 9q34 rat Y939-p 448700 EETGSEEyMNMDLGP molecular association, regulation PIK3R1(INDUCES) 7504175 3 5 47 +AREL1 AREL1 iso2 Membrane protein, integral; UBIQUITIN LIGASE; Ubiquitin conjugating system; Ubiquitin ligase O15033-2 9870 14q24.3 human T783-p 56589716 IAAPTHStLPTAHT_ HECT protein degradation; molecular association, regulation AREL1 iso2(INDUCES) 27162139 1 0 0 +Cish CISH Q62225 12700 9 F1|9 57.99 cM mouse Y253-p 62887803 MADYLRQyPFQL___ cell growth, inhibited 28038963 1 0 0 +HMGN1 HMGN1 DNA-binding; Nuclear receptor co-regulator P05114 3150 21q22.2 human K59-ac 458852 TKGKRGAkGKQAEVA HMG14_17 molecular association, regulation DNA(DISRUPTS) 10753971 1 1 0 +GMNN Geminin Cell cycle regulation; Motility/polarity/chemotaxis O75496 51053 6p22.3 human T25-p 40323301 NSSVPRRtLKMIQPS Geminin protein stabilization 23695679 1 0 0 +AKT1 Akt1 EC 2.7.11.1; KINASE; Kinase, protein; Oncoprotein; Protein kinase, AGC; Protein kinase, Ser/Thr (non-receptor) P31749 207 14q32.33 human T92-p 22776839 ERTFHVEtPEEREEW PH protein stabilization; molecular association, regulation; protein conformation; phosphorylation PIN1(INDUCES) 19448664 1 0 3 sites can increase Akt activation slightly and maintain activation and stability +YES1 Yes EC 2.7.10.2; KINASE; Kinase, protein; Oncoprotein; Protein kinase, TK; Protein kinase, tyrosine (non-receptor) P07947 7525 18p11.32 human Y426-p 447619 RLIEDNEyTARQGAK PK_Tyr_Ser-Thr phosphorylation; enzymatic activity, induced carcinogenesis, induced; cell motility, induced 33941853 7 93 3048 induces phosphorylation of ANXA2 +Cebpb C/EBP-beta DNA-binding; Motility/polarity/chemotaxis; Transcription factor P21272 24253 3q42 rat S185-p 455886 LSTSSSSsPPGTPSP transcription, altered DNA(INDUCES) 16055922 8 9 9 +USP28 USP28 DEUBIQUITINASE; EC 3.4.19.12; Protease; Ubiquitin-specific protease Q96RU2 57646 11q23.2 human K99-sm 36692602 IDLTHDNkDDLQAAI enzymatic activity, inhibited 25359778 1 1 0 +Gja1 GJA1 Channel, misc.; Membrane protein, integral; Membrane protein, multi-pass; Motility/polarity/chemotaxis P08050 24392 20q11 rat S262-p 450694 SPSKDCGsPKYAYFN cell cycle regulation; cell growth, induced; signaling pathway regulation; cell growth, altered 14702389; 23882217 29 5 4 +TXNIP TXNIP Apoptosis; Mitochondrial; Motility/polarity/chemotaxis; Tumor suppressor Q9H3M7 10628 1q21.1 human S361-p 3212304 DMDGSQDsPIFMYAP molecular association, regulation; intracellular localization cell cycle regulation COPS5(INDUCES) 30410860 1 4 5 important for p27-Kip1 stabilization by TXNIP +GPR15 GPR15 GPCR, family 1; Membrane protein, integral; Membrane protein, multi-pass; Receptor, GPCR P49685 2838 3q11.2 human S357-p 125971702 FARRRKRsVSL____ endocytosis, induced 28615320 1 0 0 +IKBKB IKKB EC 2.7.11.10; KINASE; Kinase, protein; Protein kinase, Other; Protein kinase, Ser/Thr (non-receptor) O14920 3551 8p11.21 human S733-p 5014908 TVREQDQsFTALDWS IKKbetaNEMObind molecular association, regulation; phosphorylation cell differentiation, inhibited; transcription, inhibited IKKG(DISRUPTS) 18957422; 35966593 2 2 0 +Traf6 TRAF6 EC 6.3.2.-; Ligase; UBIQUITIN LIGASE; Ubiquitin conjugating system; Ubiquitin ligase P70196 22034 2|2 E2 mouse S47-p 1040254703 ASTGNLSsSFMEEIQ ubiquitination 29563609 1 0 0 colon epithelia in?ammation +KIT Kit EC 2.7.10.1; KINASE; Kinase, protein; Membrane protein, integral; Oncoprotein; Protein kinase, TK; Protein kinase, tyrosine (receptor) P10721 3815 4q12 human Y823-p 448018 DIKNDSNyVVKGNAR PK_Tyr_Ser-Thr protein stabilization; receptor internalization, inhibited; phosphorylation cell growth, induced; apoptosis, inhibited; signaling pathway regulation 23803604 3 3 11 increased posphorylation of an adaptor protein Cbl +NFATC1 NFAT2 DNA-binding; Transcription factor O95644 4772 18q23 human S278-p 41453273 NGRQPPYsPHHSPTP activity, induced; protein stabilization carcinogenesis, induced; cell motility, induced; transcription, induced 28235034; 31730483 2 3 0 multiple sites mutatnt +IFIH1 MDA5 Apoptosis; EC 3.6.4.13; Helicase Q9BYX4 64135 2q24.2 human S828-p 40587800 GRARADEsTYVLVAH protein conformation transcription, inhibited 25865883 1 0 0 disrupts MDA5 multimer formation +SP1 SP1 C2H2-type zinc finger protein; DNA-binding; Transcription factor P08047 6667 12q13.13 human S702-p 5262508 FMRSDHLsKHIKTHQ zf-C2H2 molecular association, regulation transcription, induced HDAC1(DISRUPTS) 27320013 2 2 0 SCARB1 gene expression +VIM Vimentin Cytoskeletal; Motility/polarity/chemotaxis P08670 7431 10p13 human S56-p 451514 SRSLYASsPGGVYAT Filament_head activity, induced; molecular association, regulation; intracellular localization; phosphorylation carcinogenesis, induced; endocytosis, induced; cell motility, induced; exocytosis, induced; cytoskeletal reorganization; transcription, altered Vimentin(DISRUPTS); Cas-L(DISRUPTS); SERT(INDUCES); CDK1(INDUCES) 16990256; 16997882; 19270731; 21465480; 26369929; 27603133; 30267961; 31931758; 33525953; 36231009 32 85 227 +Notch2 Notch 2 KINASE; Kinase, protein; Membrane protein, integral; Motility/polarity/chemotaxis; Receptor, misc. Q9QW30 29492 2q34 rat S2078-p 450165 PPGTVLTsALSPVLC activity, induced cell differentiation, altered 11577080 1 1 0 +Ndel1 NDEL1 Microtubule-binding; Protease Q9ERR1 83431 11|11 B3 mouse S336-p 1869686801 LGSSRPSsAPGMLPL phosphorylation cell growth, induced; cell differentiation, induced; cytoskeletal reorganization 31815665 1 1 0 neuronal dendrite outgrowth and arborization; primes phosphorylation of S332 by GSK3beta +Rap1gap RAP1GAP GAP; GAP, Ras; Motility/polarity/chemotaxis XP_233609 313644 5q36 rat S530-p 3190708 PFGSRRSsAIGIENI cytoskeletal reorganization 19218462 4 25 25 controls dendritic spine morphology +Gabrg2 GABRG2 Channel, chloride; Channel, ligand-gated; Membrane protein, integral; Membrane protein, multi-pass; Transporter; Transporter, ion channel P22723 14406 11 A5|11 24.8 cM mouse S329-p 1869465807 RKSLPKVsYVTAMDL Neur_chan_memb intracellular localization neural plasticity; signaling pathway regulation 31618635 1 0 0 Nogo-A signaling +HMGB1 HMGB1 DNA repair, damage; Nuclear receptor co-regulator P09429 3146 13q12.3 human K12-ac 459197 DPKKPRGkMSSYAFF HMG_box_2 molecular association, regulation DNA(INDUCES) 18241198 3 5 20 +HTT Huntingtin Cytoskeletal P42858 3064 4p16.3 human K15-sm 8545505 MKAFESLkSFQQQQQ protein stabilization; intracellular localization transcription, inhibited 15064418 2 0 0 +Irf6 IRF6 DNA-binding; Transcription factor P97431 54139 1 H6|1 97.6 cM mouse S413-p 18911095 FSGDFTRsFDSGSVR phosphorylation 31578523 3 3 0 stimulates phosphorylation of S90 +RPS3 RPS3 Apoptosis; EC 4.2.99.18; RNA-binding; Ribosomal; Translation P23396 6188 11q13.4 human K214-ub 486643 HVSIVEPkDEILPTT protein degradation; ubiquitination; intracellular localization cell growth, inhibited; signaling pathway regulation 35951361; 36567344 3 12 139 inhibits NF-kB translocation into the nucleus, and disrupts NF-kB signaling pathway, inhibits proliferation and metastasis +Kcnma1 KCNMA1 iso4 Channel, potassium; Endoplasmic reticulum; Membrane protein, integral; Membrane protein, multi-pass Q08460-4 16531 14|14 A3 mouse S722-p 18264900 GRSERDCsCMSGRVR activity, induced 21209098 1 0 0 abolishes inhibition resulting from AMPK phosphorylation (of another site, presumably) +Erbb3 HER3 EC 2.7.10.1; KINASE; Kinase, protein; Membrane protein, integral; Oncoprotein; Protein kinase, TK; Protein kinase, tyrosine (receptor) Q62799 29496 7q11 rat Y1286-p 449858 CPAAEQGyEEMRAFQ molecular association, regulation; phosphorylation PIK3CB(INDUCES); PIK3R1(INDUCES) 11546794 30 10 125 induces phosphorylation of Akt1. +NEDD8 NEDD8 Ubiquitin-like modifier Q15843 4738 14q12 human K33-ac 1878097300 IKERVEEkEGIPPQQ molecular association, regulation PARP1(INDUCES) 30804002 1 1 0 +CDC37 CDC37 Chaperone Q16543 11140 19p13.2 human S339-p 62877802 HMQRCIDsGLWVPNS CDC37_C molecular association, regulation CDK4(DISRUPTS); AurB(DISRUPTS); Src(DISRUPTS) 28073914 1 1 0 +Rps6kb1 p70S6K iso2 EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, AGC; Protein kinase, Ser/Thr (non-receptor); Translation P67999-2 83840 10q26 rat T389-p 448607 NQVFLGFtYVAPSVL Pkinase_C protein degradation; enzymatic activity, induced 24961241 476 9 1 degradation of IRS1/2 +Cdkn1b p27Kip1 Cell cycle regulation; Inhibitor; Oncoprotein; Protein kinase, regulatory subunit P46414 12576 6 G1|6 65.77 cM mouse T170-p 6058800 QNKRANRtEENVSDG intracellular localization 18701472 2 0 0 Cytoplasmic p27 is unable to inhibit Cdk2 kinase activity. +CDC20 CDC20 Cell cycle regulation; Ubiquitin conjugating system Q12834 991 1p34.2 human T59-p 23092103 AGRTPGRtPGKSSSK cell cycle regulation 33819340 1 2 3 +BRAF BRAF EC 2.7.11.1; KINASE; Kinase, protein; Oncoprotein; Protein kinase, Ser/Thr (non-receptor); Protein kinase, TKL P15056 673 7q34 human T401-p 452246 STTGLSAtPPASLPG molecular association, regulation; enzymatic activity, inhibited cell growth, altered RAF1(DISRUPTS) 19933846; 21135229 3 25 10 +RRP1B RRP1B Nucleolus; RNA-binding; Ribosomal; Translation Q14684 23076 21q22.3 human S702-p 3196466 EFKKTDKsILVSPTG molecular association, regulation PPP1CC(DISRUPTS); PPP1CA(DISRUPTS) 36450254 1 10 0 +DPYSL2 CRMP-2 iso3 Microtubule-binding; Motility/polarity/chemotaxis NP_001184222 1808 8p21.2 human S623-p 448081 KTVTPASsAKTSPAK carcinogenesis, altered; cell motility, altered 24036111 9 33 17 +ITPKA ITPKA Carbohydrate Metabolism - inositol phosphate; EC 2.7.1.127; Kinase, lipid; Motility/polarity/chemotaxis P23677 3706 15q15.1 human T311-p 451074 EHAQRAVtKPRYMQW IPK enzymatic activity, induced 9155020 1 0 0 +Rreb1 RREB1 C2H2-type zinc finger protein; DNA-binding; Motility/polarity/chemotaxis; Nuclear receptor co-regulator; Transcription, coactivator/corepressor Q3UH06 68750 13|13 A3.3 mouse S970-p 4719142 AGQAEPLsPRPPPCP molecular association, regulation transcription, induced DNA(INDUCES) 31915377 1 5 0 +Bax BAX Apoptosis; Membrane protein, integral; Mitochondrial; Tumor suppressor Q07813 12028 7 B3|7 29.32 cM mouse S184-p 451017 VAGVLTAsLTIWKKM TM molecular association, regulation; intracellular localization apoptosis, inhibited MCL1(INDUCES); Bcl-xL(INDUCES) 14766748 9 0 0 +Nf2 Merlin Cytoskeletal; Motility/polarity/chemotaxis; Tumor suppressor Q63648 25744 14q21 rat S514-p 448282 DTDMKRLsMEIEKEK ERM_C cell growth, altered 16885985 33 41 1 +ADRA2A ADRA2A GPCR, family 1; Membrane protein, integral; Membrane protein, multi-pass; Receptor, GPCR P08913 150 10q25.2 human S311-p 456349 DALDLEEsSSSDHAE 7tm_1 activity, inhibited 7876239 1 2 0 +NEDD4L NEDD4L EC 6.3.2.-; EC 6.3.2.19; Ligase; UBIQUITIN LIGASE; Ubiquitin conjugating system; Ubiquitin ligase Q96PU5 23327 18q21.31 human S342-p 453438 SSRLRSCsVTDAVAE activity, induced; protein stabilization; molecular association, regulation; ubiquitination; protein conformation; activity, inhibited; phosphorylation signaling pathway regulation 14-3-3 sigma(INDUCES); NHE3(INDUCES); ENaC-beta(DISRUPTS); NKCC2(DISRUPTS); ENaC-alpha(INDUCES); SMAD3(DISRUPTS) 11742982; 15328345; 17715136; 19917253; 21852580; 24657276; 34294877; 34823064 14 17 59 inhibits NCC ubiquitination, SGK1-Nedd4-2 Pathway +NDUFB6 NDUFB6 EC 1.6.5.3; EC 1.6.99.3; Energy Metabolism - oxidative phosphorylation; Membrane protein, integral; Mitochondrial; Oxidoreductase O95139 4712 9p21.1 human S29-p 23253630 WLKDQELsPREPVLP NDUF_B6 activity, induced cell cycle regulation 24746669 1 3 1 increases mitochondrial respiration for G/2M transition +KCNJ1 ROMK Channel, potassium; Membrane protein, integral; Membrane protein, multi-pass P48048 3758 11q24.3 human S313-p 2461200 ATCQVRTsYVPEEVL IRK_C activity, induced; protein conformation; activity, inhibited 18547545; 18571730; 18620882 5 0 0 +PELI1 PELI1 Adaptor/scaffold; EC 6.3.2.-; EC 6.3.2.19; Ligase; UBIQUITIN LIGASE; Ubiquitin conjugating system; Ubiquitin ligase Q96FA3 57162 2p14 human T80-p 7388010 DQHSISYtLSRAQTV Pellino ubiquitination; enzymatic activity, induced 19264966 2 0 0 +Crhr1 CRF-R1 GPCR, family 2; Membrane protein, integral; Membrane protein, multi-pass; Receptor, GPCR P35347 12921 11 E1|11 67.77 cM mouse T413-p 25288088 FHSIKQStAV_____ molecular association, regulation PSD-95(INDUCES) 26352593 1 0 1 +MAFA MAFA DNA-binding; Oncoprotein; Transcription factor; Tumor suppressor O57342 quail T57-p 456028 LSSTPLStPCSSVPS cell differentiation, altered; transcription, altered 15963504 8 1 0 +DBN1 DBN1 iso3 Actin-binding; Cytoskeletal; Motility/polarity/chemotaxis Q16643-3 1627 5q35.3 human S647-p 472365 SEGYFSQsQEEEFAQ protein stabilization neural plasticity; cytoskeletal reorganization 30700723 2 16 14 +TH TH iso4 Amino Acid Metabolism - tyrosine; EC 1.14.16.2; Endoplasmic reticulum; Mitochondrial; Oxidoreductase; Vesicle P07101-4 7054 11p15.5 human S35-p 448544 AIMVRGQsPRFIGRR TOH_N enzymatic activity, induced 7901013 43 8 0 +ERG ERG DNA-binding; Oncoprotein; Transcription factor P11308 2078 21q22.2 human S81-p 4712347 QVNGSRNsPDECSVA transcription, induced 23918819 1 8 0 +NUP153 NUP153 Nuclear export; Nucleoporin P49790 9972 6p22.3 human T388-p 3191107 VYFKPSLtPSGEFRK Nup153 molecular association, regulation KPNB1(DISRUPTS) 19767751 1 9 4 +POLM POLM DNA repair, damage; EC 2.7.7.7; Transferase Q9NP87 27434 7p13 human T21-p 469478 SGDAASStPPSTRFP molecular association, regulation; enzymatic activity, inhibited DNA(DISRUPTS) 23933132 1 1 3 +FYB1 SLAP-130 Adaptor/scaffold O15117 2533 5p13.1 human Y651-p 452095 LDMGDEVyDDVDTSD molecular association, regulation cell adhesion, induced; cell motility, altered; cell adhesion, altered SLP76(INDUCES); NCK1(INDUCES); NCK2(INDUCES) 10570256; 20661443; 23979596; 24769494 5 4 13 +Ulk1 ULK1 Autophagy; EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, Other; Protein kinase, Ser/Thr (non-receptor) O70405 22241 5|5 F mouse S1047-p 10428800 RRLSALLsGVYA___ DUF3543 signaling pathway regulation 21855797 2 2 0 Hsp90-Cdc37-to-Ulk1-to-Atg13 pathway +Ncoa3 SRC-3 ACETYLTRANSFERASE; Acetyltransferase; EC 2.3.1.48; Motility/polarity/chemotaxis; Nuclear receptor co-regulator; Transcription, coactivator/corepressor O09000 17979 2|2 H3 mouse S850-p 454106 NRAVSLDsPVSVGSG carcinogenesis, inhibited; cell growth, inhibited; cell differentiation, induced; transcription, inhibited; signaling pathway regulation 20534466 7 16 0 inhibits insulin/IGF1 signaling +H2ac4 H2A.1 DNA-binding C0HKE1 319172 13|13 A3.1 mouse R88-m1 7836401 RHLQLAIrNDEELNK Histone chromatin organization, altered 19434510 0 2 0 regulation of senescence-related epigenetics modification +CDC42 CDC42 G protein; G protein, monomeric; G protein, monomeric, Rho; Motility/polarity/chemotaxis G1SYB4 rabbit S77-p 28716002 YDRLRPLsYPQTDVF Ras activity, induced; intracellular localization cell motility, induced 23833064 3 0 0 +ATF2 ATF-2 ACETYLTRANSFERASE; C2H2-type zinc finger protein; EC 2.3.1.48; Transcription factor P15336 1386 2q31.1 human T69-p 448224 SVIVADQtPTPTRFL activity, induced; protein degradation; protein stabilization; ubiquitination; enzymatic activity, induced cell cycle regulation; cell motility, induced; transcription, induced; transcription, altered; signaling pathway regulation 10777545; 10821277; 11313929; 12110590; 21098032; 21858082; 33893075; 7737129; 7737130; 7824938 32 57 50 +NCOR2 SMRT Nuclear receptor co-regulator; Transcription, coactivator/corepressor Q9Y618 9612 12q24.31 human S2511-p 465590 CSQYETLsDSE____ molecular association, regulation TR-alpha(INDUCES) 11451368 1 8 1 phosphorylation stabilizes SMRT interaction with TR-alpha in vitro +Drgx DRGX DNA-binding Q8BYH0 107751 14|14 B mouse S233-p 62925704 LLPSTSSsPGPASKQ protein conformation transcription, altered 28049756 1 1 0 +RND3 RhoE G protein; G protein, monomeric; G protein, monomeric, Rho; Motility/polarity/chemotaxis P61587 390 2q23.3 human S210-p 27933600 KNVKRNKsQRATKRI molecular association, regulation; intracellular localization cell cycle regulation; cytoskeletal reorganization 14-3-3 beta(INDUCES); GRF-1(DISRUPTS) 23622247; 32041905 2 0 0 +DISC1 DISC1 Cell development/differentiation; Motility/polarity/chemotaxis Q9NRI5 27185 1q42.2 human S58-p 18942701 GPGIGFLsPAVGTLF molecular association, regulation; intracellular localization transcription, induced ATF-4(DISRUPTS) 23587879 2 1 0 S58-p is localized in the cytoplasm, dephosphorylated is nuclear localized. ATF-4 DISC1 binding region acts as a transcriptional repressor to the PDE4D9 promoter. +DNMT1 DNMT1 Amino Acid Metabolism - cysteine and methionine; Cell development/differentiation; EC 2.1.1.37; METHYLTRANSFERASE; Methyltransferase; Methyltransferase, DNA; Transcription regulation P26358 1786 19p13.2 human K194-sm 12726303 AKSDESIkEEDKDQD enzymatic activity, induced DNA(INDUCES) 19450230 1 0 0 +PXN PXN Adaptor/scaffold; Cell adhesion; Cytoskeletal; Motility/polarity/chemotaxis P49024 395832 chicken Y118-p 448604 ASEEEHVySFPNKQK Paxillin molecular association, regulation cytoskeletal reorganization CDK6(INDUCES) 12949231 83 79 2519 +KRT8 K8 Cytoskeletal P05787 3856 12q13.13 human K11-ac 461564 RVTQKSYkVSTSGPR Keratin_2_head cytoskeletal reorganization 18203277; 18983182 2 2 14 +Mapk3 ERK1 EC 2.7.11.24; KINASE; Kinase, protein; Protein kinase, CMGC; Protein kinase, Ser/Thr (non-receptor) P21708 50689 1q36 rat Y205-p 447543 HTGFLTEyVATRWYR Pkinase activity, induced; intracellular localization; enzymatic activity, induced translation, altered; cell adhesion, induced; signaling pathway regulation; cell growth, altered 10473611; 11731096; 12163549; 14627993; 15757502; 16368189; 19427337; 19943942; 20096547; 21357465; 21738764; 21917714; 22076135; 34475824; 8387499 1366 142 3549 +BDKRB2 BKR2 GPCR, family 1; Membrane protein, integral; Membrane protein, multi-pass; Receptor, GPCR P30411 624 14q32.2 human Y347-p 452100 RKKSWEVyQGVCQKG activity, induced; phosphorylation 16226010 3 2 0 this increases ERK activation when stimulated with EGF+isoproterenol+bradykinin as compared to the WT BKR2.; Mutation of both tyrosines to phenylalanines prevents Gi protein-mediated cAMP accumulation induced by bradykinin +CERT1 COL4A3BP EC 2.7.11.9; KINASE; Kinase, protein; Lipid-binding; Protein kinase, Ser/Thr (non-receptor); Protein kinase, atypical Q9Y5P4 10087 5q13.3 human S149-p 4777489 GYSATSTsSFKKGHS molecular association, regulation; activity, inhibited 28652409 0 1 0 reduced PtdIns(4)P binding affinity as well as low ceramide transfer activity, E494R/N495K/P535R/E537K mutations, recovery of both PtdIns(4)P binding and ceramide transfer activity. +Nr5a1 STF-1 Nuclear receptor; Transcription, coactivator/corepressor P33242 26423 2 B|2 24.42 cM mouse K119-sm 2798301 QIRANGFkLETGPPM molecular association, regulation transcription, altered; signaling pathway regulation; transcription, inhibited GEMIN3(INDUCES) DNA(DISRUPTS) 15713642; 18838537; 21820362 7 0 0 affects hedgehog signaling +RALGAPA2 RALGAPA2 GAP; GAP, Ras Q2PPJ7 57186 20p11.23 human T715-p 460565 PMRFRSAtTSGAPGV molecular association, regulation carcinogenesis, induced; signaling pathway regulation 14-3-3 theta(INDUCES) 22580611; 23386617 2 7 54 cell invasion induced +GIT1 GIT1 GAP; GAP, ARF; Motility/polarity/chemotaxis Q9Y2X7 28964 17q11.2 human Y284-p 15702201 EELAMDVyDEVDRRE GIT_SHD molecular association, regulation; protein conformation; activity, inhibited cell motility, induced PXN(INDUCES) 24699139 4 1 0 +CTNNB1 CTNNB1 Actin-binding; Cell adhesion; Motility/polarity/chemotaxis; Nuclear receptor co-regulator; Oncoprotein; Transcription factor P35222 1499 3p22.1 human T120-p 6406005 QFDAAHPtNVQRLAE protein degradation; molecular association, regulation; intracellular localization cell growth, inhibited; transcription, induced; cell motility, inhibited; transcription, altered; transcription, inhibited CTNNA1(INDUCES) 19141652; 22511927; 24240237; 29108267 6 0 0 cytoplasmic localization, PrKD1 promoter activity, lower AR transcriptional activity +PAK1 PAK1 EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, STE; Protein kinase, Ser/Thr (non-receptor) Q13153 5058 11q13.5-q14.1 human K148-ub 56714905 KYMSFTDkSAEDYNS protein degradation 27302166 1 0 0 +GJA1 GJA1 Channel, misc.; Membrane protein, integral; Membrane protein, multi-pass; Motility/polarity/chemotaxis P17302 2697 6q22.31 human S255-p 448852 HATSGALsPAKDCGS molecular association, regulation; intracellular localization; activity, inhibited; protein conformation endocytosis, induced; cell growth, inhibited FLNB(DISRUPTS); CLTA(INDUCES) 15605363; 22737133; 23828237; 24492000; 26161412; 36164986 23 21 1 +Sgk1 SGK1 EC 2.7.11.1; KINASE; Kinase, protein; Motility/polarity/chemotaxis; Protein kinase, AGC; Protein kinase, Ser/Thr (non-receptor) Q06226 29517 1p12 rat T256-p 448431 EHNGTTStFCGTPEY Pkinase enzymatic activity, induced 10357815 15 0 0 +ID2 ID2 DNA-binding; Transcription, coactivator/corepressor Q02363 3398 2p25.1 human T27-p 4706880 LGISRSKtPVDDPMS protein stabilization cell growth, inhibited 26756672 3 2 0 +CDC42BPA MRCKA EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, AGC; Protein kinase, Ser/Thr (non-receptor) Q5VT25 8476 1q42.13 human T403-p 12612503 HLPFVGFtYTSSCVL Pkinase_C enzymatic activity, induced cytoskeletal reorganization 11283256 1 0 0 +EPAS1 HIF2A DNA-binding; Transcription factor Q99814 2034 2p21 human T324-p 471073 VWLETQGtVIYNPRN PAS_3 molecular association, regulation apoptosis, induced; transcription, altered SP1(DISRUPTS) 17024177 1 0 0 +ACLY ACLY Carbohydrate Metabolism - citrate (TCA) cycle; EC 2.3.3.8; Lyase; Transferase P53396 47 17q21.2 human Y682-p 450360 SRTTDGVyEGVAIGG Ligase_CoA acetylation; enzymatic activity, induced carcinogenesis, induced 32420483 1 23 363 +Mip AQP0 Channel, misc.; Membrane protein, integral; Membrane protein, multi-pass; Transporter, aquaporin family P09011 25480 7q11 rat S233-p 450116 KSVSERLsILKGARP molecular association, regulation; intracellular localization 18523655; 22194645 6 9 0 No differences in the interaction with filensin between the AQP0 COOH-terminal peptide and its pseudophosphorylated proteins +Myocd myocardin Cell development/differentiation; Transcription factor Q8VIM5 214384 11|11 B3 mouse S458-p 3627512 HFGSTSSsPPISPAS transcription, inhibited 16141410 1 0 0 +MAF MAF Cell development/differentiation; DNA-binding; Oncoprotein; Transcription factor; Tumor suppressor O75444 4094 16q23.2 human Y92-p 25673105 KAHLEDYyWMTGYPQ Maf_N activity, induced; molecular association, regulation transcription, induced DNA(INDUCES) 22798672 2 0 0 Interacts with IL-4 promoter and transactivates IL-4 +ATF2 ATF-2 ACETYLTRANSFERASE; C2H2-type zinc finger protein; EC 2.3.1.48; Transcription factor P15336 1386 2q31.1 human T71-p 448225 IVADQTPtPTRFLKN activity, induced; protein degradation; protein stabilization; ubiquitination; enzymatic activity, induced cell cycle regulation; cell motility, induced; transcription, induced; transcription, altered; signaling pathway regulation; cell growth, altered 10777545; 10821277; 11313929; 12110590; 12208955; 21098032; 21858082; 21878628; 33893075; 7737129; 7737130; 7824938 53 54 37 +Fgf2 FGF2 Activator; Motility/polarity/chemotaxis P15655 14173 3 B|3 18.41 cM mouse Y81-p 13823202 KGVCANRyLAMKEDG FGF intracellular localization 20230531 2 1 0 essential for FGF2 secretion +PPARG PPAR-gamma iso3 DNA-binding; Nuclear receptor; Transcription factor P37231-3 5468 3p25.2 human S84-p 448062 AIKVEPAsPPYYSEK cell cycle regulation; cell growth, induced; transcription, inhibited 24440556 33 7 0 Cell growth is regulated by cell cycle arrest. +STK4 MST1 Autophagy; EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, STE; Protein kinase, Ser/Thr (non-receptor) Q13043 6789 20q13.12 human T183-p 447925 DTMAKRNtVIGTPFW Pkinase activity, induced; molecular association, regulation; intracellular localization; phosphorylation; enzymatic activity, induced cell cycle regulation; carcinogenesis, inhibited; cell growth, inhibited; apoptosis, induced; cell motility, inhibited; transcription, inhibited; signaling pathway regulation GJA1(INDUCES); MOBKL2A(INDUCES) 11805089; 22619175; 24362629; 24872389; 30903103; 31679687; 35804016; 36115593; 36164986; 36622276; 37319316 25 2 5 +Clip1 Restin Cytoskeletal Q9JK25 65201 12q16 rat S309-p 4769827 TPASLKRsPSASSLS molecular association, regulation; protein conformation TUBA1C(DISRUPTS) 20519438 1 11 1 +NHERF1 NHERF Adaptor/scaffold; Motility/polarity/chemotaxis O14745 9368 17q25.1 human S340-p 455753 RAHQKRSsKRAPQMD EBP50_C molecular association, regulation CFTR(INDUCES); Ezrin(DISRUPTS) 17613530; 35140182 5 1 12 +Hcls1 HS1 Adaptor/scaffold; Motility/polarity/chemotaxis P49710 15163 16|16 B3 mouse Y405-p 451636 DEDAEGDyEDVLEPE molecular association, regulation; intracellular localization ITK(INDUCES) 15166239; 19917685 9 1 7 +KRT8 K8 Cytoskeletal P05787 3856 12q13.13 human S291-p 3081700 IKYEELQsLAGKHGD Filament protein conformation 11850543 1 8 5 Conformational change in K8 gene intermediate filaments. +NF2 Merlin Cytoskeletal; Motility/polarity/chemotaxis; Tumor suppressor P35240 4771 22q12.2 human S315-p 487469 MRRRKADsLEVQQMK FERM_C protein degradation; molecular association, regulation; phosphorylation carcinogenesis, induced; cell motility, induced; cell growth, induced CD44(DISRUPTS) 17891137; 21750658 4 6 0 induces phosphorylation at S518 +NAT1 NAT1 ACETYLTRANSFERASE; Acetyltransferase; EC 2.3.1.5; Secondary Metabolites Metabolism - caffeine; Xenobiotic Metabolism - drug metabolism - other enzymes P18440 9 8p22 human K188-ac 36302509 LEDSKYRkIYSFTLK Acetyltransf_2 molecular association, regulation; enzymatic activity, inhibited PPAT(DISRUPTS) 32487734 1 1 0 acetylation inhibited the allosteric effects of ATP on NAT1 +RYR2 RYR2 Channel, ligand-gated; Membrane protein, integral; Membrane protein, multi-pass; Transporter; Transporter, ion channel Q92736 6262 1q43 human S2814-p 458801 ISQTSQVsVDAAHGY activity, induced signaling pathway regulation 22304913; 29760186; 30571258 63 8 5 induces CAMKKB-AMPK pathway; release of Ca2+ in KI cardiomycetes; increased leak load relationship, enhanced Ca buffering and regulates Ca handling +EGFR EGFR EC 2.7.10.1; KINASE; Kinase, protein; Membrane protein, integral; Oncoprotein; Protein kinase, TK; Protein kinase, tyrosine (receptor) P00533 1956 7p11.2 human S1070-p 448051 DSFLQRYsSDPTGAL receptor desensitization, altered; receptor internalization, altered 1309762; 7505275 17 6 7 +Lats2 LATS2 EC 2.7.11.1; KINASE; Kinase, protein; Nuclear receptor co-regulator; Protein kinase, AGC; Protein kinase, Ser/Thr (non-receptor); Tumor suppressor Q7TSJ6 50523 14|14 C3 mouse S830-p 10945601 HQRCLAHsLVGTPNY Pkinase enzymatic activity, induced cell growth, altered 12853976 5 3 15 +EIF2AK3 PERK EC 2.7.11.1; KINASE; Kinase, protein; Membrane protein, integral; Protein kinase, Other; Protein kinase, Ser/Thr (non-receptor); Translation Q9NZJ5 9451 2p11.2 human Y585-p 35518100 NDIKNSGyISRYLTD enzymatic activity, induced signaling pathway regulation 25113558 1 1 0 STAT3 activation, PERK-JAK1-STAT3 pathway +CAPN2 CAPN2 EC 3.4.22.53; Motility/polarity/chemotaxis; Protease P17655 824 1q41 human K390-sm 7780001 MNPQYLIkLEEEDED Calpain_III enzymatic activity, induced cell motility, induced 19422794 1 0 0 +Lmna lamin A/C Cytoskeletal P48678 16905 3 F1|3 38.84 cM mouse S392-p 452606 ERLRLSPsPTSQRSR chromatin organization, altered 31576060 11 105 85 +SQSTM1 SQSTM1 Autophagy; Nuclear receptor co-regulator; Ubiquitin conjugating system Q13501 8878 5q35.3 human K420-ub 12256934 LTRLLQTkNYDIGAA UBA_5 protein degradation; ubiquitination autophagy, induced; autophagy, inhibited SQSTM1(DISRUPTS) 28380357; 31241013; 34987184 4 8 25 inhibits p62 phase condensation and dimerization, sequestration of Keap1 and Nrf2-mediated stress response +Lat LAT Adaptor/scaffold; Membrane protein, integral O54957 16797 7|7 F3 mouse Y136-p 447760 EDDYPNGyLVVLPDS LAT activity, induced; intracellular localization; phosphorylation cell differentiation, altered; apoptosis, altered; apoptosis, induced; cell adhesion, altered; signaling pathway regulation; cell growth, altered Fyn(INDUCES) 12065839; 12065840; 15470052; 17081783; 17579183; 20130215; 30911567 24 1 1 Localization of recruited PLCG2 to the membrane/cytoskeleton; ERK phosphorylation; Fyn may be involved in LAT phosphorylation.; upregulation of TGF-beta/SMAD signaling in Hypertrophic Patchymeningitis, increased Th2 cell proliferation, regulates infiltration of blood cells +DAB2 DAB2 Adaptor/scaffold; Tumor suppressor P98082 1601 5p13.1 human T221-p 449256 DLFGDMStPPDLNSP intracellular localization 21097498 1 6 7 displacement of Dab2 from the membrane +SRF SRF Motility/polarity/chemotaxis; Transcription factor P11831 6722 6p21.1 human S162-p 460665 LRRYTTFsKRKTGIM SRF-TF transcription, inhibited 16537394; 19778940 2 0 0 +FUS hnRNP P2 DNA-binding; Nuclear receptor co-regulator; Oncoprotein; RNA splicing; RNA-binding; SUMO LIGASE P35637 2521 16p11.2 human S163-p 1878186700 GQQNQYNsSSGGGGG molecular association, regulation hnRNP P2(DISRUPTS) 35753345 1 1 0 +STIM1 STIM1 Calcium-binding; Endoplasmic reticulum; Membrane protein, integral Q13586 6786 11p15.4 human S608-p 3195758 PSAPPGGsPHLDSSR molecular association, regulation; intracellular localization; activity, inhibited; protein conformation cell motility, induced EB1(DISRUPTS) 25447552; 25562429; 28935720 7 19 0 GPER activation to inhibit SOCE; accelerates cell migration in wound-healing assays; NFAT translocation to the nucleus, multimerization +Oprk1 KOR-1 GPCR, family 1; Membrane protein, integral; Membrane protein, multi-pass; Receptor, GPCR P33534 18387 1 A1|1 1.89 cM mouse S369-p 449609 NTVQDPAsMRDVGGM activity, induced; receptor internalization, induced; receptor desensitization, altered; intracellular localization; phosphorylation signaling pathway regulation 14597630; 19773548; 21370032; 26635353; 35652052 11 1 0 induces phosphorylation of ERK1/2 and p38MAPK, induces KOR/ p38MAPK signaling +Met Met EC 2.7.10.1; KINASE; Kinase, protein; Membrane protein, integral; Oncoprotein; Protein kinase, TK; Protein kinase, tyrosine (receptor) P16056 17295 6 A2|6 7.83 cM mouse Y1311-p 450189 EYCPDALyEVMLKCW PK_Tyr_Ser-Thr molecular association, regulation cell motility, altered; cytoskeletal reorganization GRB2(INDUCES); PIK3C2A(INDUCES); GAB1(INDUCES); SHC1(INDUCES) 10069803; 7708691 6 1 4 activates cell mobility +BCL2 Bcl-2 Apoptosis; Autophagy; Membrane protein, integral; Oncoprotein P10415 596 18q21.33 human T74-p 448632 ARTSPLQtPAAPGAA protein stabilization; ubiquitination apoptosis, altered; apoptosis, induced; apoptosis, inhibited 10669763; 11077443; 12039864 4 0 0 +MORC2 MORC2 DNA-binding Q9Y6X9 22880 22q12.2 human T717-p 3217917 PSPKVIKtPVVKKTE protein degradation; molecular association, regulation cell cycle regulation; carcinogenesis, inhibited; autophagy, induced; cell growth, inhibited; apoptosis, induced LAMP2(INDUCES); HSC70(INDUCES) 36967563 1 9 1 +RAF1 RAF1 EC 2.7.11.1; KINASE; Kinase, protein; Oncoprotein; Protein kinase, Ser/Thr (non-receptor); Protein kinase, TKL P04049 5894 3p25.2 human S497-p 3082308 ATVKSRWsGSQQVEQ PK_Tyr_Ser-Thr enzymatic activity, induced 10998357; 8288587 2 2 0 +PKM PKM Carbohydrate Metabolism - glycolysis and gluconeogenesis; Carbohydrate Metabolism - pyruvate; EC 2.7.1.40; KINASE; Kinase, other; Mitochondrial; Nucleotide Metabolism - purine P14618 5315 15q23 human Y105-p 450528 FASDPILyRPVAVAL PK molecular association, regulation; intracellular localization; enzymatic activity, inhibited; protein conformation; enzymatic activity, induced cell cycle regulation; carcinogenesis, induced; cell motility, induced; cell growth, induced; apoptosis, inhibited; transcription, induced PKM iso2(DISRUPTS); PKM(DISRUPTS); TRIM35(DISRUPTS) 23814019; 24100037; 25208557; 25263439; 25645022; 33623435; 33800513; 34966685; 35054968; 36400183; 36428781 29 33 414 +EZR Ezrin Cytoskeletal; Motility/polarity/chemotaxis P15311 7430 6q25.3 human T567-p 448104 QGRDKYKtLRQIRQG ERM_C activity, induced; molecular association, regulation; intracellular localization; activity, inhibited; protein conformation; phosphorylation cell cycle regulation; carcinogenesis, induced; cell growth, inhibited; cell motility, induced; cell adhesion, induced; signaling pathway regulation; cell differentiation, altered; exocytosis, induced; cell motility, altered; cytoskeletal reorganization; cell adhesion, altered Ezrin(DISRUPTS); Moesin(DISRUPTS); ACTA1(INDUCES) 10893267; 10970850; 14993232; 15531580; 15843435; 16144865; 16873375; 17553936; 18725408; 19386264; 21818323; 21864676; 21979959; 24379416; 24413175; 25375189; 25799996; 26042733; 26405038; 31409639; 31936668; 33583073; 33836044; 34493594; 34540823; 35325754; 35482006; 36899847 68 9 16 +Pink1 PINK1 EC 2.7.11.1; KINASE; Kinase, protein; Membrane protein, integral; Mitochondrial; Protein kinase, Other; Protein kinase, Ser/Thr (non-receptor) Q99MQ3 68943 4|4 D3 mouse S227-p 25792200 MWNISAGsSSEAILS autophagy, induced; cell growth, induced 35145192 8 2 0 induces mitophagy +USP16 USP16 DEUBIQUITINASE; EC 3.4.19.12; Protease; Ubiquitin conjugating system; Ubiquitin-specific protease Q9Y5T5 10600 21q21.3 human T554-p 3217539 EVLTSSPtRNLNGAY UCH protein degradation 28380042 1 5 0 +STING1 STING Apoptosis; Endoplasmic reticulum; Membrane protein, integral; Membrane protein, multi-pass; Mitochondrial Q86WV6 340061 5q31.2 human S366-p 31064700 QEPELLIsGMEKPLP activity, induced; protein degradation; protein stabilization; molecular association, regulation; intracellular localization; phosphorylation carcinogenesis, inhibited; apoptosis, inhibited; transcription, induced; transcription, inhibited; signaling pathway regulation AP1M1(INDUCES); IRF3(INDUCES); STING(INDUCES); AP1S1(INDUCES) 24119841; 25636800; 31527250; 33906974; 34799452; 36261523; 36972172 35 3 0 +PXN PXN iso2 Adaptor/scaffold; Cell adhesion; Cytoskeletal; Motility/polarity/chemotaxis P49023-2 5829 12q24.23 human S126-p 450227 SFPNKQKsAEPSPTV Paxillin cell cycle regulation; carcinogenesis, altered; transcription, altered 20628053 8 28 4 regulates Erk1/2-induced cell proliferation and transcription +Prkaa1 AMPKA1 Autophagy; EC 2.7.11.1; EC 2.7.11.26; EC 2.7.11.27; EC 2.7.11.31; KINASE; Kinase, protein; Protein kinase, CAMK; Protein kinase, Ser/Thr (non-receptor) Q5EG47 105787 15|15 A1 mouse S496-p 450431 ATPQRSGsISNYRSC AdenylateSensor protein degradation; molecular association, regulation; ubiquitination; enzymatic activity, inhibited; phosphorylation TRIM72(INDUCES) 24928508; 33400924 19 46 55 +CAMKK2 CAMKK2 Autophagy; EC 2.7.11.17; KINASE; Kinase, protein; Protein kinase, Other; Protein kinase, Ser/Thr (non-receptor) Q96RR4 10645 12q24.31 human S511-p 2861414 RREERSLsAPGNLLT molecular association, regulation; enzymatic activity, inhibited; phosphorylation 14-3-3 beta(INDUCES) 15209507; 32913128 3 32 15 increases autophosphorylation; inhibits dephosphorylation at S495 +SH2B1 SH2-B-beta Adaptor/scaffold Q9NRF2 25970 16p11.2 human Y753-p 408589400 PRAINNQySFV____ cell growth, inhibited; signaling pathway regulation 29229648 1 0 0 Expression of NGF-responsive genes reduced, inhibit NGF signaling pathway +GSK3B GSK3B EC 2.7.11.1; EC 2.7.11.26; KINASE; Kinase, protein; Protein kinase, CMGC; Protein kinase, Ser/Thr (non-receptor) P49841 2932 3q13.33 human S147-p 51621301 YRVARHYsRAKQTLP Pkinase enzymatic activity, induced 26711256 1 0 0 +CDK9 CDK9 Cell cycle regulation; EC 2.7.11.22; EC 2.7.11.23; KINASE; Kinase, protein; Nuclear receptor co-regulator; Protein kinase, CMGC; Protein kinase, Ser/Thr (non-receptor) P50750 1025 9q34.11 human T186-p 450950 NSQPNRYtNRVVTLW Pkinase protein stabilization; molecular association, regulation; intracellular localization; enzymatic activity, induced carcinogenesis, induced; DNA repair, induced; cell growth, induced; transcription, induced; transcription, inhibited; transcription, altered HEXIM1(INDUCES); HSP90A(DISRUPTS); BRD4(DISRUPTS); TEAD1(INDUCES); CCNT1(INDUCES); EDG-1(INDUCES) RNA(INDUCES) 14627702; 15965233; 18483222; 21098020; 21448926; 21533037; 23658523; 29743242; 36253486 16 28 10 +TET2 TET2 EC 1.14.11.n2; Oxidoreductase; Tumor suppressor Q6N021 54790 4q24 human K1299-ub 38492200 SMYYNGCkFARSKIP Tet_JBP molecular association, regulation; intracellular localization; enzymatic activity, induced DNA(INDUCES) 25557551 1 0 0 +CDKN1A p21Cip1 Cell cycle regulation; Inhibitor P38936 1026 6p21.2 human S146-p 447836 GRKRRQTsMTDFYHS protein degradation; protein stabilization; molecular association, regulation; intracellular localization apoptosis, induced; cell growth, altered 10753973; 11756412; 17855660; 23886938 10 1 0 +Arrb2 ARRB2 Adaptor/scaffold P29067 25388 10q24 rat T277-p 50247604 FCKVYTItPLLSDNR Arrestin_C activity, induced; molecular association, regulation; protein conformation ADRB2(INDUCES); GRK2(INDUCES) 31948726 2 1 0 induces pre-active state +P2rx7 P2X7 Channel, ligand-gated; Membrane protein, integral; Membrane protein, multi-pass; Receptor, misc. Q64663 29665 12q16 rat Y550-p 2179300 SKLRHCAyRSYATWR P2RX7_C cytoskeletal reorganization 11707406 1 0 0 +APPL1 APPL Adaptor/scaffold; Nuclear receptor co-regulator Q9UKG1 26060 3p14.3 human S401-p 449251 ALEAVTPsPSFQQRH signaling pathway regulation 21562756 2 42 0 adiponectin signalling pathway +Smad2 SMAD2 DNA-binding; Transcription factor Q62432 17126 18 E3|18 51.42 cM mouse S467-p 447495 SVRCSSMs_______ molecular association, regulation; intracellular localization carcinogenesis, induced; cell growth, induced; cell motility, induced; cell growth, inhibited; cell differentiation, induced; transcription, induced; signaling pathway regulation SMAD4(INDUCES) 32122971; 34655614; 34799661; 35538070; 37350664 57 1 5 +GAPDH GAPDH Carbohydrate Metabolism - glycolysis and gluconeogenesis; EC 1.2.1.12; Oxidoreductase P04406 2597 12p13.31 human S151-p 3178959 LKIISNAsCTTNCLA activity, induced; molecular association, regulation cell motility, induced; cell growth, induced TRAF2(INDUCES) 37450367 1 17 1 K139 ubiquitylation promotes cell proliferation and motility-migration and metastasis; K139 is critical for its binding to TRAF2 and activation of the NF-kB pathways leading to proliferation and migration +MTMR2 MTMR2 Carbohydrate Metabolism - fructose and mannose; Cofactor and Vitamin Metabolism - riboflavin; Cofactor and Vitamin Metabolism - thiamine; EC 3.1.3.64; EC 3.1.3.95; Motility/polarity/chemotaxis; PHOSPHATASE; Phosphatase, lipid; Protein phosphatase, tyrosine (non-receptor) Q13614 8898 11q21 human S58-p 3195800 STSADNFsPDLRVLR molecular association, regulation; intracellular localization signaling pathway regulation RAB5A(DISRUPTS); APPL(DISRUPTS) 21372139; 23378027 2 29 0 inhibits binding and targting to early endosomes, regulates endosomal shuttling; enhances EGF signaling; localization of S58A mutant to early endosomal structures results in dephosphorylation of PI(3) +EYA3 EYA3 EC 3.1.3.48; PHOSPHATASE; Protein phosphatase, tyrosine (non-receptor) Q99504 2140 1p35.3 human Y77-p 1869778703 QMYSAKPyAHILSVP cell growth, altered 31847183 1 1 0 +Pdpk1 PDK1 EC 2.7.11.1; KINASE; Kinase, protein; Nuclear receptor co-regulator; Protein kinase, AGC; Protein kinase, Ser/Thr (non-receptor) Q9Z2A0 18607 17|17 A3.3 mouse S532-p 5938009 TYYLMDPsGNAHKWC PH_3 enzymatic activity, inhibited 19047061 1 0 0 +BNIP3L BNIP3L Apoptosis; Endoplasmic reticulum; Membrane protein, integral; Mitochondrial; Nuclear envelope O60238 665 8p21.2 human S35-p 65958201 PPAGLNSsWVELPMN BNIP3 molecular association, regulation autophagy, induced LC3B(INDUCES) 28442745 2 0 0 +Cebpa C/EBP-alpha DNA-binding; Transcription factor P05554 24252 1q21 rat T226-p 449825 GHPTPPPtPVPSPHP activity, inhibited transcription, altered 16600022 8 0 0 In 3T3L1 preadipocytes, mutation of T222/T226 to alanines increased transcription at CBE-containing promoter (as compared to WT C/EBP-alpha). S230A had a similar effect as the double T->A mutation. The triple alanine mutation had the highest transcription of the reporter gene. S230A did not reduce T222/226 phosphorylation (although CHIR99021 inhibitor did). +CDC25A CDC25A EC 3.1.3.48; Motility/polarity/chemotaxis; PHOSPHATASE; Protein phosphatase, dual-specificity P30304 993 3p21.31 human S76-p 449340 SNLQRMGsSESTDSG protein degradation; molecular association, regulation; ubiquitination; phosphorylation cell cycle regulation BTRC(INDUCES) 12110582; 12759351; 14681206; 14752276; 15798217; 18167338; 19734889; 20348946; 22179839 12 1 1 +ARHGAP35 GRF-1 GAP; GAP, Rac/Rho; Motility/polarity/chemotaxis; Transcription factor; Tumor suppressor Q9NRY4 2909 19q13.32 human S1236-p 7159801 PKPKPRPsITKATWE RhoGAP_pG1_pG2 activity, inhibited 19103606 2 5 0 +MSH3 MSH3 DNA repair, damage P20585 4437 5q14.1 human K122-ac 9930497 MSGNSEPkKCLRTRN intracellular localization 32900932 1 0 1 +CHKB CHKB EC 2.7.1.32; EC 2.7.1.82; Kinase, other; Lipid Metabolism - glycerophospholipid Q9Y259 1120 22q13.33 human S39-p 5208526 TPKRRRAsSLSRDAE enzymatic activity, induced 27149373 1 9 2 +Msx1 MSX1 DNA-binding; Motility/polarity/chemotaxis P13297 17701 5 B3|5 20.21 cM mouse S136-p 50783957 DALVKAEsPEKLDRT cell cycle regulation; cell growth, induced; transcription, induced; signaling pathway regulation 33080014 1 3 0 Fgf/MAPK signaling for cell growth +Bub1b BUB1B EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, Other; Protein kinase, Ser/Thr (non-receptor); Tumor suppressor Q9Z1S0 12236 2|2 E5 mouse S659-p 3207630 ALIIKKLsPIIEESR intracellular localization; phosphorylation 26028219 9 35 0 Kinetochore-Microtubule attachment destabilization, PP2A-B56 recruitment to KTs; decrease CASC5 phosphorylation +SRSF1 SF2 RNA splicing; RNA-binding; Spliceosome Q07955 6426 17q22 human S133-p 15178110 SGLPPSGsWQDLKDH RRM_1 molecular association, regulation carcinogenesis, inhibited; RNA splicing, inhibited RNA(DISRUPTS) 32453427; 36417875 2 2 2 +CALR Calreticulin ACETYLTRANSFERASE; Acetyltransferase; Calcium-binding; Motility/polarity/chemotaxis; Nuclear receptor co-regulator; Secreted; Secreted, signal peptide P27797 811 19p13.13 human K238-ac 4219809 SKPEDWDkPEHIPDP Calreticulin protein conformation 18795239 1 3 0 +BLNK BLNK Adaptor/scaffold Q8WV28 29760 10q24.1 human Y96-p 447719 EENADDSyEPPPVEQ molecular association, regulation transcription, altered PLCG1(INDUCES); PLCG2(INDUCES); Btk(INDUCES); NCK2(INDUCES); VAV1(INDUCES) 12456653; 9697839 6 1 0 +Camk2b CAMK2B EC 2.7.11.17; KINASE; Kinase, protein; Protein kinase, CAMK; Protein kinase, Ser/Thr (non-receptor) P08413 24245 14q21 rat T287-p 450048 SMMHRQEtVECLKKF activity, induced; molecular association, regulation; intracellular localization; enzymatic activity, induced; phosphorylation cell growth, inhibited; signaling pathway regulation RPT6(INDUCES); CAMK2A(INDUCES); ACTN4(DISRUPTS); CAMK2B(INDUCES); MARCKS(INDUCES); SYN1(INDUCES) 17144902; 20178748; 21725312; 23490331; 25944910; 9681448 32 17 109 diabetes-type1 and type2-related signaling in brain; phosphorylation decreased dendritic length +CSF3R GCSFR Membrane protein, integral; Receptor, cytokine Q99062 1441 1p34.3 human K705-ub 9381804 VLEEDEKkPVPWESH receptor internalization, induced; protein degradation; intracellular localization; phosphorylation cell growth, inhibited; signaling pathway regulation 19453968 2 0 0 regulates production of neutrophilic granulocytes, regulates STAT5 activation +Crebbp CBP ACETYLTRANSFERASE; Acetyltransferase; DNA-binding; EC 2.3.1.48; Motility/polarity/chemotaxis; Nuclear receptor co-regulator; Transcription, coactivator/corepressor Q6JHU9 54244 10q12 rat S301-p 448068 PQLASKQsMVNSLPA transcription, induced 11970865 1 0 0 +Cebpb C/EBP-beta DNA-binding; Motility/polarity/chemotaxis; Transcription factor P28033 12608 2 H3|2 87.58 cM mouse S64-p 456166 HERAIDFsPYLEPLA protein conformation cell growth, inhibited; transcription, altered; transcription, inhibited 15878863; 21804532 8 0 1 the 3'UTRC/EBP-beta alters target gene speci?city +Alyref2 Refbp2 DNA-binding; RNA-binding Q9JJW6 56009 1|1 H3 mouse R40-m2 13906420 PAIARGGrNRPAPYS molecular association, regulation RNA(DISRUPTS) 20129943 1 1 0 +PHF8 PHF8 DEMETHYLASE; Demethylase; EC 1.14.11.27; Nucleolus Q9UPP1 23133 Xp11.22 human S854-p 3216123 DAEYIYPsLESDDDD molecular association, regulation TOPBP1(INDUCES) 33010150 1 25 15 +ACTA1 ACTA1 Cell development/differentiation; Contractile; Cytoskeletal; Motility/polarity/chemotaxis P68135 rabbit K317-ac 474928 GIADRMQkEITALAP Actin activity, inhibited 30962575 1 4 7 CAP/actin inhibitory potency +Jun Jun Oncoprotein; Transcription factor P05627 16476 4 C5|4 43.34 cM mouse K229-sm 2793916 HPRLQALkEEPQTVP Jun molecular association, regulation transcription, inhibited DNA(DISRUPTS) 10788439; 23396363 5 2 0 +GJD2 GJD2 Cell adhesion; Channel, misc.; Membrane protein, integral; Membrane protein, multi-pass Q9UKL4 57369 15q14 human S315-p 471389 PNFGRTQsSDSAYV_ molecular association, regulation PSD-95(DISRUPTS) 33110101 2 1 0 +Kdr VEGFR2 EC 2.7.10.1; KINASE; Kinase, protein; Membrane protein, integral; Protein kinase, TK; Protein kinase, tyrosine (receptor) P35918 16542 5 C3.3|5 40.23 cM mouse Y1173-p 447901 AQQDGKDyIVLPMSE activity, induced; receptor internalization, induced; molecular association, regulation; protein stabilization; intracellular localization; phosphorylation signaling pathway regulation 20434959; 21402774; 21543326; 25119572 40 0 0 +Atm ATM DNA repair, damage; EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, Ser/Thr (non-receptor); Protein kinase, atypical; Tumor suppressor Q62388 11920 9 A5.3|9 29.12 cM mouse S1899-p 467199 PANSDSEsENFLRCC chromatin organization, altered 19047460 3 3 0 +SLC39A7 SLC39A7 Membrane protein, integral; Membrane protein, multi-pass; Transporter; Transporter, SLC family Q92504 7922 6p21.32 human T294-p 26420164 QKRRGGStVPKDGPV Zip activity, induced; phosphorylation exocytosis, induced; signaling pathway regulation 28205653 1 1 1 maximal activation, SLC39A7 and Akt activation, zinc release and downstream effectors GSK3B, and p70 S6, phosphorylation of multiple kinases +NABP2 OBFC2B Cell cycle regulation; DNA repair, damage Q9BQ15 79035 12q13.3 human T117-p 12526701 EPNPEYStQQAPNKA protein stabilization FBXO15(DISRUPTS) DNA(INDUCES) 23178594; 25249620 4 1 0 +LAT LAT iso2 Adaptor/scaffold; Membrane protein, integral O43561-2 27040 16p11.2 human T155-p 451994 PSAPALStPGIRDSA LAT activity, inhibited 15192708 1 0 11 +MARK2 MARK2 EC 2.7.11.1; EC 2.7.11.26; KINASE; Kinase, protein; Protein kinase, CAMK; Protein kinase, Ser/Thr (non-receptor) Q7KZI7 2011 11q13.1 human S569-p 2192738 PQRVPVAsPSAHNIS cell cycle regulation; carcinogenesis, induced; apoptosis, inhibited 35780183 1 30 0 +BTG2 BTG2 Transcription factor P78543 7832 1q32.1 human K5-ub 1877015604 ___MSHGkGTDMLPE protein degradation cell cycle regulation; cell growth, induced 31992359 1 1 0 +Crmp1 CRMP-1 Cell development/differentiation; Cytoskeletal; Hydrolase Q62950 25415 14q21 rat Y504-p 454682 GMYDGPVyEVPATPK molecular association, regulation cell growth, induced; signaling pathway regulation FLNA(INDUCES) 33449368 3 13 208 induces Sema3A signaling +RB1 Rb Nuclear receptor co-regulator; Oncoprotein; Transcription, coactivator/corepressor; Tumor suppressor P06400 5925 13q14.2 human R775-m2 36533404 ILQYASTrPPTLSPI Rb_C phosphorylation cell cycle regulation; transcription, inhibited 25348716 1 0 0 +KCNB1 Kv2.1 Channel, cation; Channel, ligand-gated; Channel, potassium; Membrane protein, integral; Membrane protein, multi-pass Q14721 3745 20q13.13 human K149-sm 1877715601 EQMNEELkREAETLR exocytosis, inhibited 31085831 1 0 0 controlled the occurrence of membrane fusion +LGALS3 galectin-3 Cell surface; Extracellular matrix; Motility/polarity/chemotaxis P17931 3958 14q22.3 human S12-p 451567 FSLHDALsGSGNPNP protein conformation 24269589; 26911284 4 1 0 may allosterically influence carbohydrate binding to the S-face; little effect on interactions between the NT and CRD F-face; Phosphorylation of S6 and S12 In N-terminal promotes association with carbohydrate recognition domain (CRD), while phosphorylation of Y107 and Y118 attenuates this interaction. +CSNK2B CK2B KINASE; Protein kinase, regulatory subunit P67870 1460 6p21.33 human S3-p 447647 _____MSsSEEVSWI protein stabilization 12032843 2 11 0 +Bcl2l11 BIM Apoptosis O88498 64547 3q36 rat K3-ub 25087001 _____MAkQPSDVNS protein degradation 21378313 3 0 0 BIM was still degraded in the absence of these lysines defining a novel ubiquitin-independent pathway. +Grk2 GRK2 EC 2.7.11.15; KINASE; Kinase, protein; Protein kinase, AGC; Protein kinase, Ser/Thr (non-receptor) Q99MK8 110355 19 A|19 3.98 cM mouse Y13-p 456872 AVLADVSyLMAMEKS cell motility, altered 18369319 5 0 0 +TLR3 TLR3 Membrane protein, integral; Receptor, cytokine O15455 7098 4q35.1 human Y759-p 450187 EQFEYAAyIIHAYKD TIR molecular association, regulation; phosphorylation signaling pathway regulation; transcription, altered TICAM1(INDUCES) 12509442; 17178723; 22810896 4 0 0 antiviral TLR3 signaling; increases phosphorylation of some NFKB sites +YAP1 YAP1 Oncoprotein; Transcription, coactivator/corepressor P46937 10413 11q22.1 human S227-p 1874514400 VQQNMMNsASGPLPD protein stabilization; molecular association, regulation; ubiquitination carcinogenesis, induced; cell growth, induced; transcription, induced DNA(INDUCES) 34345207 1 0 0 +RORA RORA DNA-binding; Nuclear receptor P35398 6095 15q22.2 human R37-m2 1883509400 PLNQESArKSEPPAP protein degradation 36114756 1 0 0 PRMT5 is involved in RORa degradation by regulating ITCH binding R37A (mutant) +PAK2 PAK2 EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, STE; Protein kinase, Ser/Thr (non-receptor) Q13177 5062 3q29 human Y139-p 3571405 SNTVKQKyLSFTPPE enzymatic activity, induced 12215529 2 5 46 +BCAR1 P130Cas Adaptor/scaffold; Motility/polarity/chemotaxis P56945 9564 16q23.1 human Y287-p 451538 RDPLLEVyDVPPSVE cell growth, induced 26867768 2 17 284 metastases +CHRM2 mAChR M2 GPCR, family 1; Membrane protein, integral; Membrane protein, multi-pass; Receptor, GPCR P08172 1129 7q33 human T287-p 459103 KESSNDStSVSAVAS 7tm_1 receptor internalization, altered 9162044 3 0 0 Mutation of S286 T287 S288 S290 to A caused a faster rate and a greater extent of receptor internalization after agonist stimulation (transients only, not observed in stables). Mutation of all 8 sites prevented internalization (in both transients and stables). +NPM1 NPM1 Nucleolus; Oncoprotein; RNA-binding; Translation P06748 4869 5q35.1 human K229-ac 461146 SKGQESFkKQEKTPK molecular association, regulation; intracellular localization transcription, altered H3(INDUCES) 19581289 1 3 116 K212/215/229/230/257/267/292R mutant +Tsc2 TSC2 iso2 Cell cycle regulation; GAP; GAP, misc.; Nuclear receptor co-regulator; Tumor suppressor P49816-2 24855 10q12 rat S1346-p 450212 QPLSKSSsSPELQTL phosphorylation apoptosis, altered; cell growth, altered 14651849; 17244624 19 14 6 +Stat3 STAT3 DNA-binding; Motility/polarity/chemotaxis; Nuclear receptor co-regulator; Transcription factor P42227 20848 11 D|11 63.82 cM mouse T717-gl 90001800 FICVTPTtCSNTIDL transcription, inhibited 28280036 1 1 0 +Mybl2 B-Myb DNA-binding; Motility/polarity/chemotaxis; Transcription factor P48972 17865 2 H2|2 84.0 cM mouse T447-p 452026 NSLTPKStPVKTLPF activity, induced 9840932 3 0 0 +Lipe HSL EC 3.1.1.79; Lipase P15304 25330 1q21 rat S960-p 450195 GFHPRRSsQGVLHMP Abhydrolase_3 transcription, induced 28716938 29 14 16 regulation of steroidogenesis +Lpp LPP Adaptor/scaffold; Cytoskeletal; Motility/polarity/chemotaxis Q8BFW7 210126 16|16 B1 mouse Y297-p 463380 YTSNQGRyYEPYYAA cell cycle regulation; cell motility, altered 18515860 1 4 21 +Pygl PYGL Carbohydrate Metabolism - starch and sucrose; EC 2.4.1.1; Transferase Q9ET01 110095 12 C2|12 29.01 cM mouse K470-ac 14321567 IVKTQVFkDFSELEP Phosphorylase enzymatic activity, inhibited; phosphorylation PPP1CA(INDUCES) 22225877 1 3 0 acetylation enhances its interaction with the PPP1CA substrate-targeting PL, promoting PYGL dephosphorylation +USF1 USF1 DNA-binding; Transcription factor P22415 7391 1q23.3 human S186-p 15428820 APRTHPYsPKSEAPR activity, induced 21873430 1 12 8 +RLIM RNF12 EC 6.3.2.-; Ligase; Transcription, coactivator/corepressor; UBIQUITIN LIGASE; Ubiquitin conjugating system; Ubiquitin ligase Q9NVW2 51132 Xq13.2 human S215-p 18014966 QRRARSRsPDHRRTR intracellular localization cell motility, induced; apoptosis, inhibited 23904271 1 0 0 phosphorylated S214 (human) or S215 (murine) RNF12 is localized in nucleus; shuttling of RNF12 is important for promoting cell motility and alveolar cell survival +DVL2 DVL2 Adaptor/scaffold; Motility/polarity/chemotaxis O14641 1856 17p13.1 human T206-p 17301000 MTSELEStSLGDSDE Dishevelled cell cycle regulation 20823832 1 0 0 +CTNND1 CTNND1 Actin-binding; Adaptor/scaffold; Cell adhesion; G protein regulator, misc.; Motility/polarity/chemotaxis O60716 1500 11q12.1 human T906-p 469141 SLDNNYStPNERGDH molecular association, regulation; ubiquitination carcinogenesis, induced; cytoskeletal reorganization SMURF1(INDUCES) 32010791 1 17 76 facilitates adherens junction dissociation +PML PML Nucleolus; Oncoprotein; SUMO LIGASE; SUMO conjugating system; SUMO ligase; Transcription factor; Tumor suppressor; Ubiquitin conjugating system P29590 5371 15q24.1 human S36-p 451469 PSEGRQPsPSPSPTE sumoylation apoptosis, altered 19015637 2 15 0 induces sumoylation +RPS6KA5 MSK1 EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, AGC; Protein kinase, Ser/Thr (non-receptor) O75582 9252 14q32.11 human S376-p 448216 EKLFQGYsFVAPSIL Pkinase_C enzymatic activity, induced 15568999 23 19 41 +NPAT NPAT Cell cycle regulation; Transcription regulation Q14207 4863 11q22.3 human S1100-p 2286403 VSFPNLDsPNVSSTL NPAT_C transcription, induced 10995387 1 1 0 multiple sites deletion mutant +CENPA CENPA DNA-binding P49450 1058 2p23.3 human S19-p 478530 APRRRSPsPTPTPGP Histone molecular association, regulation; intracellular localization; protein conformation cell cycle regulation; cell growth, induced HJURP(DISRUPTS) 23818633; 28760857 2 39 8 chromosome segregation; localization to centromeres, tumor progression +AFF1 AF-4 Oncoprotein; Transcription factor P51825 4299 4q21.3-q22.1 human K972-ac 1878271700 DLHMREAkKMKQKAE molecular association, regulation; intracellular localization transcription, inhibited MLLT3(DISRUPTS); CDK9(DISRUPTS); ELL(DISRUPTS) 31611376 1 0 0 Acetylation inhibits SEC component recruitment and is required for transcription inhibition and cell survival after exposure to genotoxic reagents. +Nup62 NUP62 Adaptor/scaffold; Nucleoporin P17955 65274 1q22 rat Y425-p 463925 KEQSGTIyLQHADEE Nsp1_C intracellular localization 25349423 1 0 5 +Ppp2r5b PPP2R5B Motility/polarity/chemotaxis; Protein phosphatase, regulatory subunit Q6PD28 225849 19|19 A mouse S46-p 18261152 ARPRRSHsSSQFRYQ molecular association, regulation; phosphorylation PPP2CA(INDUCES); PPP2R5B(INDUCES) 21329884 1 4 1 PPP2R2R5B phosphorylation by CLK2 is required for the PPP2CA-AKT complex; induces AKT dephosphorylation +CEACAM1 CEACAM1 Cell adhesion; Immunoglobulin superfamily; Membrane protein, integral; Motility/polarity/chemotaxis P13688 634 19q13.2 human T457-p 3439801 CFLHFGKtGRASDQR molecular association, regulation; activity, inhibited apoptosis, altered Calmodulin(DISRUPTS) 19146852; 30639287 5 1 0 calcium-calmodulin binding ; blocks formation of lumen +MEN1 MEN1 iso1 Transcription, coactivator/corepressor O00255-1 4221 11q13.1 human S399-p 477697 EERPGEQsQGTQSQG Menin phosphorylation 21264250 1 2 6 important for dephosphorylation of S487 +KCNQ1 Kv7.1 Channel, potassium; Membrane protein, integral; Membrane protein, multi-pass P51787 3784 11p15.5-p15.4 human T513-p 456164 LREHHRAtIKVIRRM KCNQ_channel activity, induced 12879210 1 0 0 +TBXA2R TXA2-R iso2 GPCR, family 1; Membrane protein, integral; Membrane protein, multi-pass; Receptor, GPCR P21731-2 6915 19p13.3 human S330-p 18790001 LSTRPRRsLTLWPSL receptor desensitization, altered 12147288; 14530262 2 0 0 +SIRT1 SIRT1 Apoptosis; DEACETYLASE; Deacetylase; EC 3.5.1.-; Nuclear receptor co-regulator Q96EB6 23411 10q21.3 human S615-p 7998455 GEKNERTsVAGTVRK molecular association, regulation; acetylation; protein conformation; enzymatic activity, induced transcription, induced p53(INDUCES); DBC1(DISRUPTS) 34216621 1 4 9 inhibits PGC-1a deacetylation +Prkn PARK2 EC 6.3.2.-; EC 6.3.2.19; Ligase; Translation; Translation regulation; UBIQUITIN LIGASE; Ubiquitin conjugating system; Ubiquitin ligase Q9JK66 56816 1q11 rat S65-p 25538008 NCDLEQQsIVHIVQR ubiquitin ubiquitination; enzymatic activity, induced ubiquitin(INDUCES) 26254304 34 10 0 RING0/RING1 interface are remodelled, PARK2 is activated by phosphorylation of its N-terminal ubiquitin-like (Ubl) domain and binding of phosphoubiquitin. +Fosl2 FRA2 DNA-binding; Transcription factor P47930 14284 5 B1|5 17.33 cM mouse T322-p 14573760 SDSLNSPtLLAL___ protein stabilization cell differentiation, inhibited 23807221 2 5 0 +PELI1 PELI1 Adaptor/scaffold; EC 6.3.2.-; EC 6.3.2.19; Ligase; UBIQUITIN LIGASE; Ubiquitin conjugating system; Ubiquitin ligase Q96FA3 57162 2p14 human T288-p 7388016 QCPVGFNtLAFPSMK Pellino ubiquitination; enzymatic activity, induced 19264966 2 0 0 +Glp1r GLP1R GPCR, family 2; Membrane protein, integral; Membrane protein, multi-pass; Receptor, GPCR P32301 25051 20p12 rat S451-p 451369 SSGATVGsSVYAATC receptor desensitization, altered 8702711 1 0 0 +RBL2 Rb-like 2 Transcription, coactivator/corepressor; Tumor suppressor Q08999 5934 16q12.2 human S688-p 449729 RLFVENDsPSDGGTP molecular association, regulation cell cycle regulation E2F4(DISRUPTS) 11157749 3 6 0 +DENR DENR RNA-binding; Translation O43583 8562 12q24.31 human S73-p 476007 AKLTVENsPKQEAGI protein stabilization; molecular association, regulation cell cycle regulation; translation, induced MCTS1(INDUCES) 35115540 1 52 0 +KIF4A KIF4A Microtubule-binding; Motor O95239 24137 Xq13.1 human T799-p 479906 PPKLRRRtFSLTEVR molecular association, regulation; intracellular localization; enzymatic activity, induced cell cycle regulation; cytoskeletal reorganization PRC1(INDUCES) 23940115; 25512391; 28992084; 31881080 5 27 161 +TP53BP1 53BP1 DNA repair, damage; Transcription, coactivator/corepressor Q12888 7158 15q15.3 human S1778-p 458312 FNKQYTEsQLRAGAG apoptosis, altered 19876065 5 0 1 +Mlph MLPH Adaptor/scaffold Q91V27 171531 1 D|1 45.73 cM mouse S498-p 7103618 SGKPRRKsGIPIFLP Rab_eff_C molecular association, regulation TUBA1A(DISRUPTS) 28559319 1 5 0 +KCNQ2 Kv7.2 Channel, potassium; Membrane protein, integral; Membrane protein, multi-pass O43526 3785 20q13.33 human S476-p 481668 ADQSLEDsPSKVPKS KCNQ_channel activity, inhibited neural plasticity 36070693 2 5 0 +HOXB7 HOXB7 DNA-binding; Motility/polarity/chemotaxis; Transcription factor P09629 3217 17q21.32 human T204-p 465572 KTAGPGTtGQDRAEA cell differentiation, altered 11290787 1 0 0 +IFNAR2 IFNAR2 Membrane protein, integral; Receptor, cytokine P48551 3455 21q22.11 human Y269-p 26416400 VTLKWIGyICLRNSL molecular association, regulation transcription, induced; signaling pathway regulation STAT2(DISRUPTS) 34813358 2 0 0 induces STAT phosphorylation and signaling +LRRK2 LRRK2 EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, Ser/Thr (non-receptor); Protein kinase, TKL Q5S007 120892 12q12 human S955-p 4725908 RKRKILSsDDSLRSS protein stabilization; ubiquitination; enzymatic activity, inhibited; phosphorylation 25009464; 34144124 15 7 0 induces dephosphorylation at autophosphorylation sites; inhibits ubiquitination +NEIL2 NEIL2 DNA repair, damage; EC 4.2.99.18; Hydrolase; Lyase; Microtubule-binding Q969S2 252969 8p23.1 human K50-ac 458948 QDTQVHGkKLFLRFD enzymatic activity, inhibited DNA repair, inhibited 15175427 1 1 0 +FANCD2 FANCD2 DNA repair, damage Q9BXW9 2177 3p25.3 human S705-p 1883582906 NLLPLLFsQDFAKDG activity, induced; molecular association, regulation; ubiquitination; intracellular localization signaling pathway regulation DNA(INDUCES) 37392383 1 1 0 regulates the FA pathway +RIPK1 RIPK1 EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, Ser/Thr (non-receptor); Protein kinase, TKL Q13546 8737 6p25.2 human K316-ub 21183588 SNENAVVkRMQSLQL protein degradation 35711363 2 4 0 degradation and inhibited necroptosis +Rag1 RAG1 DNA-binding; EC 3.1.-.-; EC 6.3.2.-; EC 6.3.2.19; Ligase; UBIQUITIN LIGASE; Ubiquitin conjugating system; Ubiquitin ligase P15919 19373 2 E2|2 53.88 cM mouse K233-ub 41389904 QPNVQLSkKLKTVLN RAG1_imp_bd ubiquitination; enzymatic activity, induced 26124138; 34402853 2 0 0 helps restrict RAG1 protein levels, but does not result in impaired B cell development and decreased Igh, Igk, Igl and Tcrb recombination (P326G mice). ; autoubiquitylation; induces DNA cleavage by V(D)J recombination +NPHP1 NPHP1 Cell adhesion O15259 4867 2q13 human S126-p 26395105 EESESEDsEDSGGEE molecular association, regulation; intracellular localization PACS-1(INDUCES) 16308564 1 0 0 +SUPT5H SPT5 RNA-binding; Transcription, coactivator/corepressor O00267 6829 19q13.2 human R681-m2 475964 HPSAGGQrGGFGSPG transcription, inhibited 12718890 1 3 0 inhibition of in vitro transcription assays and HIV-1 gene expression +STX5 STX5 iso2 Membrane protein, integral Q13190-2 6811 11q12.3 human K270-ub 15398358 AAHSEILkYFQSVTS SNARE molecular association, regulation cell cycle regulation BET1(DISRUPTS); NSFL1C(INDUCES) 27404360 1 0 1 regulation of Golgi structure assembly, Golgi fragmentation +NKX3-1 NKX3-1 DNA-binding; Transcription factor; Tumor suppressor Q99801 4824 8p21.2 human Y222-p 28750700 NSYPYYPyLYCVGSW molecular association, regulation; phosphorylation ATM(INDUCES) 23890999 1 0 0 induces phosphorylation of p53 +Nfatc2 NFAT1 DNA-binding; Transcription factor Q60591 18019 2 H3|2 88.91 cM mouse S238-p 449626 DSCLGRHsPVPRPAS transcription, inhibited 11030334 0 14 6 +IFI16 IFI16 Transcription factor Q16666 3428 1q23.1 human K128-ac 4129126 EATPGAQkRKKSTKE intracellular localization 22691496 1 1 12 +HNRNPUL1 E1B-AP5 RNA splicing; RNA-binding Q9BUJ2 11100 19q13.2 human R656-m2 15381104 SGGGGNYrGGFNRSG molecular association, regulation; intracellular localization NBS1(INDUCES) 26020839 1 2 13 ecruitment at sites of damage +RPA1 RPA1 DNA-binding P27694 6117 17p13.3 human K449-sm 580826242 WKTLYEVkSENLGQG DNA repair, induced 22661229 1 2 0 +PPARG PPAR-gamma iso2 DNA-binding; Nuclear receptor; Transcription factor P37231-2 5468 3p25.2 human K265-ac 25780501 GEDKIKFkHITPLQE transcription, induced 28416226 4 1 0 +SYK Syk EC 2.7.10.2; KINASE; Kinase, protein; Protein kinase, TK; Protein kinase, tyrosine (non-receptor) P43405 6850 9q22.2 human Y631-p 459327 LRLRNYYyDVVN___ enzymatic activity, altered transcription, altered 9624129 3 2 2 +RGS4 RGS4 GAP; GAP, RGS Q0R4E4 100009014 rabbit S108-p 25752012 IKSPSKLsPKAKKIY RGS molecular association, regulation G-alpha(q)(INDUCES) 24407588 1 0 1 +Bcl2l11 BIM Apoptosis O54918 12125 2|2 F1 mouse S73-p 3306339 PGPFATRsPLFIFVR protein degradation apoptosis, inhibited 18498746 3 15 6 +HNRNPK hnRNP K RNA splicing; RNA-binding; Spliceosome P61978 3190 9q21.32 human Y230-p 456001 QPYDPNFyDETYDYG translation, altered 12052863 1 1 2 based on Y72/225/230/234/236/380A mutant +App APP Apoptosis; Cell surface; Membrane protein, integral; Receptor, misc.; Transcription factor P12023 11820 16 C3.3|16 46.92 cM mouse Y757-p 448202 SKMQQNGyENPTYKF APP_amyloid molecular association, regulation SHC1(INDUCES) 11877420 14 20 864 +E2F1 E2F1 DNA-binding; Transcription factor Q01094 1869 20q11.22 human K185-m1 14985900 QLIAKKSkNHIQWLG E2F_TDP protein degradation; acetylation; ubiquitination; phosphorylation apoptosis, inhibited; transcription, inhibited 20603083; 27132511 3 0 0 stabilization of the E2F1-K185L mutant; inhibits phosphorylation of E2F1 at S364 and acetylation at a distant residue +ITGB4 ITGB4 Cell adhesion; Membrane protein, integral; Motility/polarity/chemotaxis; Receptor, misc. P16144 3691 17q25.1 human S1356-p 451653 YSDDVLRsPSGSQRP molecular association, regulation cell motility, altered; cytoskeletal reorganization Plectin-1(DISRUPTS) 17615294; 20870721 6 3 2 +SFN 14-3-3 sigma Adaptor/scaffold P31947 2810 1p36.11 human S69-p 454996 LSSIEQKsNEEGSEE 14-3-3 molecular association, regulation carcinogenesis, induced; cell growth, induced; transcription, induced; signaling pathway regulation SMAD3(INDUCES); p53(DISRUPTS) DNA(INDUCES) 23741479 2 1 0 Regulates stemness and radioresistance in breast cancer cells; TGFb/Smad3 and p53/21 signaling pathways +AURKB AurB EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, Other; Protein kinase, Ser/Thr (non-receptor) Q96GD4 9212 17p13.1 human T73-p 23085287 DILTRHFtIDDFEIG protein stabilization cell cycle regulation; carcinogenesis, induced; cell growth, induced 34301793 1 1 1 +NCOA3 SRC-3 ACETYLTRANSFERASE; Acetyltransferase; EC 2.3.1.48; Motility/polarity/chemotaxis; Nuclear receptor co-regulator; Transcription, coactivator/corepressor Q9Y6Q9 8202 20q13.12 human S1042-p 4252806 DDLVGPPsNLEGQSD protein stabilization; molecular association, regulation PSMA3(DISRUPTS) 18313384 1 0 0 some subset of these 8 residues +PGR PR DNA-binding; Nuclear receptor; Transcription factor P06401 5241 11q22.1 human K464-m1 31839903 TLECILYkAEGAPPQ Prog_receptor molecular association, regulation cell adhesion, induced; transcription, induced SMRT(INDUCES); N-CoR1(INDUCES) 24415758 1 1 0 regulates ligand-sensitivity and PR activity +IL10RA IL10RA Membrane protein, integral; Receptor, cytokine Q13651 3587 11q23.3 human Y496-p 449608 PPALAKGyLKQDPLE molecular association, regulation Src(DISRUPTS); CSRP1(INDUCES); STAT3(DISRUPTS) 12802285; 26956044 2 0 1 +Pik3r1 PIK3R1 KINASE; Kinase, lipid; Motility/polarity/chemotaxis P26450 18708 13 D1|13 53.92 cM mouse S652-p 20831301 TFLVRESsKQGCYAC SH2 molecular association, regulation signaling pathway regulation 21825134 1 1 0 impairs PI3K pathway activation; inhibits binding to to phospho-Tyr peptides +TP63 p63 iso2 DNA-binding; Transcription factor Q9H3D4-2 8626 3q28 human T357-p 34371382 QHLLQKQtSIQSPSS molecular association, regulation DNA(INDUCES) 34761935 0 1 1 +SPDEF SPDEF DNA-binding; Motility/polarity/chemotaxis; Nuclear receptor co-regulator; Transcription factor O95238 25803 6p21.31 human S238-p 54165904 SEESWTDsEVDSSCS protein degradation cell motility, induced 26885618 1 0 0 enhances migration and invasion of prostate cancer cells +Acaca ACC1 Carbohydrate Metabolism - propanoate; Carbohydrate Metabolism - pyruvate; EC 6.3.4.14; EC 6.4.1.2; Ligase; Lipid Metabolism - fatty acid biosynthesis Q5SWU9 107476 11|11 C mouse S79-p 448292 FHMRSSMsGLHLVKQ enzymatic activity, inhibited carcinogenesis, induced; autophagy, induced; apoptosis, inhibited; autophagy, inhibited 25050742; 33779513; 34425110; 34588305; 35483524 166 76 11 +JAK2 JAK2 EC 2.7.10.2; KINASE; Kinase, protein; Oncoprotein; Protein kinase, TK; Protein kinase, tyrosine (non-receptor) O60674 3717 9p24.1 human K912-sm 31899106 LQHDNIVkYKGVCYS PK_Tyr_Ser-Thr molecular association, regulation; intracellular localization GH receptor(DISRUPTS) 23581279 1 0 0 translocation into the nucleus +Mapt Tau ACETYLTRANSFERASE; Acetyltransferase; Cytoskeletal P10637 17762 11 67.79 cM|11 E1 mouse T473-p 447932 KTTPSPKtPPGSGEP neural plasticity 35701839; 36186135 107 36 23 +LIMD1 LIMD1 Motility/polarity/chemotaxis; Tumor suppressor Q9UGP4 8994 3p21.31 human S277-p 451975 RVSPGLPsPNLENGA cell cycle regulation; carcinogenesis, inhibited; cell growth, inhibited; cell motility, inhibited 30600590 1 18 9 mitotic phosphorylation required for mitotic progression +FHOD1 FHOD1 Actin-binding Q9Y613 29109 16q22.1 human S1131-p 451843 AARERKRsRGNRKSL activity, induced cytoskeletal reorganization; cell growth, altered FHOD1(DISRUPTS) 18239683; 21106951 3 1 4 autoinhibitory interaction between C- and N-terminal part of FHOD1 is attenuated in S1130D/S1136D/T1140D triple mutant +PML PML Nucleolus; Oncoprotein; SUMO LIGASE; SUMO conjugating system; SUMO ligase; Transcription factor; Tumor suppressor; Ubiquitin conjugating system P29590 5371 15q24.1 human K515-ac 4659503 QPRPSTSkAVSPPHL DUF3583 sumoylation cell cycle regulation; apoptosis, induced 18621739 1 0 0 +CSF2RB CSF2RB Membrane protein, integral; Receptor, cytokine P32927 1439 22q12.3 human Y711-p 450123 DPGVASGyVSSADLV activity, induced; molecular association, regulation; phosphorylation apoptosis, altered; cell motility, altered; transcription, altered; cell growth, altered GRB2(INDUCES); SHC1(INDUCES); SHP-2(INDUCES) 10329850; 10672044; 9257712 3 0 0 Phosphorylation of Y628, Y711, or Y766 is necessary and sufficient for STAT activation by IL-5. +Ppargc1a PGC-1 alpha Nuclear receptor co-regulator; Transcription, coactivator/corepressor O70343 19017 5|5 C1 mouse S538-p 486320 SLFDVSPsCSSFNSP transcription, altered 17609368 1 1 0 +PML PML iso4 Nucleolus; Oncoprotein; SUMO LIGASE; SUMO conjugating system; SUMO ligase; Transcription factor; Tumor suppressor; Ubiquitin conjugating system P29590-4 5371 15q24.1 human T28-p 451468 PTMPPPEtPSEGRQP protein stabilization apoptosis, altered 15093545 1 1 0 Phosphorylation of PML is associated with enhanced sumoylation and apoptosis induced by As2O3. +SNAI2 Snail2 Apoptosis; C2H2-type zinc finger protein; Motility/polarity/chemotaxis; Transcription factor O43623 6591 8q11.21 human K116-ac 59171802 EEERLQSkLSDPHAI protein degradation; ubiquitination carcinogenesis, inhibited; transcription, induced 27783945 1 1 0 +Pou5f1 Oct4 DNA-binding; Transcription factor P20263 18999 17 B1|17 18.69 cM mouse S12-p 18496900 LASDFAFsPPPGGGD protein degradation cell cycle regulation 31306665 2 0 0 dispensable for self-renewal and pluripotency of mouse ES cells; +ULK1 ULK1 Autophagy; EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, Other; Protein kinase, Ser/Thr (non-receptor) O75385 8408 12q24.33 human S423-p 1880900310 GRAGPFSsSRCGASV protein degradation autophagy, inhibited 35931119 1 0 0 +Raf1 RAF1 EC 2.7.11.1; KINASE; Kinase, protein; Oncoprotein; Protein kinase, Ser/Thr (non-receptor); Protein kinase, TKL Q99N57 110157 6 E3|6 53.62 cM mouse S233-p 448651 ASSQHRYsTPHAFTF enzymatic activity, inhibited cell growth, altered 11997508 3 1 2 +PGRMC1 PGRMC1 Membrane protein, integral; Receptor, misc. O00264 10857 Xq24 human S181-p 452525 GEEPTVYsDEEEPKD molecular association, regulation; phosphorylation cell cycle regulation; carcinogenesis, induced; apoptosis, altered; cell growth, induced; apoptosis, induced; apoptosis, inhibited; transcription, induced PHB(INDUCES) 18922159; 19340614; 29069804; 34830790; 35137666 6 115 149 induces AKT/ERK phosphorylation; binding to PHB inhibits PHB binding to ER-alpha +GATA4 GATA4 Motility/polarity/chemotaxis; Transcription factor G1FC91 water buffalo S35-p 450013 IKPQRRLsASRRVGL molecular association, regulation transcription, induced DNA(INDUCES) 22245270 9 1 1 binds CYP19 gene promoter and induces its transcription +Myl9 MRLC1 Contractile; Motility/polarity/chemotaxis Q64122 296313 3q42 rat S20-p 1863500 KRPQSATsNVFAMFD cytoskeletal reorganization 21887379 49 65 294 T19, S20 di-phosphorylation is recquired for dendritic spine maturation; mono phosphorylation inhibits spine maturation. +CERT1 COL4A3BP EC 2.7.11.9; KINASE; Kinase, protein; Lipid-binding; Protein kinase, Ser/Thr (non-receptor); Protein kinase, atypical Q9Y5P4 10087 5q13.3 human S150-p 4777494 YSATSTSsFKKGHSL molecular association, regulation; activity, inhibited 28652409 0 3 3 reduced PtdIns(4)P binding affinity as well as low ceramide transfer activity, E494R/N495K/P535R/E537K mutations, recovery of both PtdIns(4)P binding and ceramide transfer activity. +CKAP2 CKAP2 Cell cycle regulation Q8WWK9 26586 13q14.3 human S628-p 7603500 FLTPVRRsRRLQEKT CKAP2_C intracellular localization 20458174 2 0 1 +cas9 Cas9 EC 3.1.-.- Q99ZW2 901176 bacteria K848-sm 1883443100 IVPQSFLkDDSIDNK HNH_4 protein stabilization; molecular association, regulation DNA(INDUCES) 35022246 1 1 0 +Krt8 K8 Cytoskeletal P11679 16691 15 F2|15 57.2 cM mouse S438-p 448540 SSYGGLTsPGFSYGM molecular association, regulation; intracellular localization cytoskeletal reorganization 10623656; 16563375 27 8 23 +DDX5 DDX5 EC 3.6.4.13; Helicase; Nuclear receptor co-regulator; Nucleolus; RNA splicing; RNA-binding; Spliceosome P17844 1655 17q23.3 human T446-p 15409321 GTAYTFFtPNNIKQV apoptosis, induced 23110695 1 2 4 +ACE2 ACE2 EC 3.4.17.23; Membrane protein, integral; Protease Q9BYF1 59272 Xp22.2 human K26-ub 1880091001 STIEEQAkTFLDKFN Peptidase_M2 protein degradation 35894122 1 1 0 +ABCA4 ABCA4 Membrane protein, integral; Membrane protein, multi-pass; Transporter; Transporter, ABC family P78363 24 1p22.1 human S1317-p 20940703 AGQTPQDsNVCSPGA enzymatic activity, induced 21721517 1 1 0 +Ulk1 ULK1 Autophagy; EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, Other; Protein kinase, Ser/Thr (non-receptor) O70405 22241 5|5 F mouse S638-p 2192504 DFPKTPSsQNLLTLL cell cycle regulation; autophagy, induced; cell growth, induced 32516310 2 9 4 +Zfp24 ZNF24 C2H2-type zinc finger protein; DNA-binding; Transcription factor Q91VN1 59057 18|18 A2 mouse S274-p 7320450 ILHQRIHsGEKPYGC molecular association, regulation cell differentiation, inhibited; transcription, inhibited DNA(DISRUPTS) 29786073 1 9 11 regulates oligodendrocyte differentiation and CNS myelination +Cited1 CITED1 Nuclear receptor co-regulator P97769 12705 X D|X 45.25 cM mouse S73-p 27937112 GSTSPIGsPTATPSS CITED intracellular localization cell differentiation, induced 23529225 1 0 0 S63/64/65/67/69/73/79/80/84A mutation in CITED1 inhibits its translocation into the nucleus and osteoblasts differentiation +Stat1 STAT1 DNA-binding; Transcription factor P42225 20846 1 C1.1|1 26.81 cM mouse S708-p 7723201 YIKTELIsVSEVHPS transcription, altered 17332413 2 2 0 +Rcan1 RCAN1 Inhibitor Q9JHG6 54720 16 C4|16 53.6 cM mouse T246-p 21511701 QTRRPEYtPIHLS__ molecular association, regulation RCAN1(INDUCES) 24021800 2 0 0 induces RCAN1 oligomers and insoluble aggregates +ARHGEF2 ARHGEF2 iso2 GEF; GEF, Rac/Rho; Motility/polarity/chemotaxis Q92974-2 9181 1q22 human T678-p 449343 PGVELLLtPREPALP activity, induced; intracellular localization 24356971 4 10 29 perinuclear localization, complement induced ARHGEF2 activation +APC APC Motility/polarity/chemotaxis; Tumor suppressor P25054 324 5q22.2 human S1279-p 450136 SRCSSLSsLSSAEDE APC_r molecular association, regulation transcription, altered CTNNB1(INDUCES) 11487578 1 0 0 +CRKL CRKL Adaptor/scaffold; Motility/polarity/chemotaxis P46109 1399 22q11.21 human Y207-p 447954 IPEPAHAyAQPQTTT molecular association, regulation; enzymatic activity, inhibited; activity, inhibited carcinogenesis, induced; cell growth, induced; apoptosis, inhibited; signaling pathway regulation PXN(DISRUPTS) 20697350; 22169110; 9710592 15 20 1215 Y207 is a negative regulatory phosphorylation site in CrkL; RAF-MEK-ERK pathway +Ezh2 EZH2 EC 2.1.1.43; METHYLTRANSFERASE; Methyltransferase; Methyltransferase, protein lysine Q61188 14056 6 B2.3|6 22.92 cM mouse Y696-p 463307 HSVNPNCyAKVMMVN SET molecular association, regulation; enzymatic activity, inhibited carcinogenesis, induced; cell growth, induced; apoptosis, inhibited; transcription, induced; signaling pathway regulation H3(DISRUPTS); POLR2A(INDUCES) 32461334 1 1 1 Regulation of Src/EZH2/c-Jun pathway; inhibits methyl transferase activity +CCKBR CCKBR GPCR, family 1; Membrane protein, integral; Membrane protein, multi-pass; Receptor, GPCR P32239 887 11p15.4 human S442-p 17825903 RLSYTTIsTLGPG__ molecular association, regulation ARRB1(INDUCES) 21156802 1 0 0 +Grin2a NMDAR2A Channel, ligand-gated; Membrane protein, integral; Membrane protein, multi-pass P35436 14811 16 A1|16 5.28 cM mouse S1459-p 481117 RVYKKMPsIESDV__ NMDAR2_C molecular association, regulation; receptor recycling, induced neural plasticity SNX27(INDUCES); PSD-95(DISRUPTS) 32877683 2 8 2 Regulates NMDAR interactions and trafficking +Pax5 PAX5 Oncoprotein Q02650 18507 4 B1|4 23.55 cM mouse Y102-p 34364233 VVEKIAEyKRQNPTM PAX protein degradation; ubiquitination carcinogenesis, inhibited; cell growth, inhibited; transcription, inhibited 36064939 1 0 1 +GCK GK Carbohydrate Metabolism - amino sugar and nucleotide sugar; Carbohydrate Metabolism - galactose; Carbohydrate Metabolism - glycolysis and gluconeogenesis; Carbohydrate Metabolism - starch and sucrose; EC 2.7.1.2; Kinase, other; Mitochondrial P35557 2645 7p13 human K459-sm 27581518 VSAVACKkACMLGQ_ protein stabilization; enzymatic activity, induced 23297408 1 1 0 +CFTR CFTR Channel, chloride; EC 3.6.3.49; Hydrolase; Membrane protein, integral; Membrane protein, multi-pass; Transporter; Transporter, ABC family P13569 1080 7q31.2 human K447-sm 52485001 VLKDINFkIERGQLL ABC_tran protein degradation; protein conformation 26627832 1 0 0 formation of a non-native formation of a non-native CFTR NBD1 protein conformation +H3C1 H3 DNA-binding P68431 8350 6p22.2 human K79-m1 459011 REIAQDFkTDLRFQS Histone molecular association, regulation chromatin organization, altered; transcription, inhibited L3MBTL iso4(INDUCES) 19805358; 23583077 16 21 41 regulates nucleosome dynamics +Hdac1 HDAC1 DEACETYLASE; Deacetylase; EC 3.5.1.98; Hydrolase; Nuclear receptor co-regulator O09106 433759 4 D2.2|4 63.26 cM mouse K432-ac 4219803 EEGEGGRkNSSNFKK acetylation; enzymatic activity, inhibited 19822520 2 0 0 inhibits activity of itself and of HDAC2 and hence results in increased histone acetylation +NR3C1 GR DNA-binding; Mitochondrial; Nuclear receptor; Transcription factor P04150 2908 5q31.3 human K494-ac 3287302 NLEARKTkKKIKGIQ receptor desensitization, induced; molecular association, regulation transcription, induced; transcription, inhibited NFkB-p65(DISRUPTS) DNA(DISRUPTS) 16380507; 19141540 2 0 0 +Wnk4 WNK4 EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, Other; Protein kinase, Ser/Thr (non-receptor) Q80UE6 69847 11|11 D mouse K238-ub 40323308 VRFYDSWkSVLRGQV Pkinase protein degradation 23576762 1 1 0 regulates electrolyte homeostasis and involved in Pseudohypoaldosteronism type II (PHAII) pathogenesis +Itgb4 ITGB4 Cell adhesion; Membrane protein, integral; Motility/polarity/chemotaxis; Receptor, misc. A2A863 192897 11 E2|11 80.91 cM mouse Y1560-p 456323 LLGYSVEyQLLNGGE fn3 apoptosis, induced; cytoskeletal reorganization; signaling pathway regulation 30187999 6 0 1 a6?4/FAK/p38 pathway regulation; increased desmin expression; podocyte injury; decreased WT1, synaptopodin expression +Ikzf1 Ikaros C2H2-type zinc finger protein; DNA-binding; Transcription factor Q03267 22778 11 A1|11 7.02 cM mouse T140-p 451354 MVHKRSHtERPFQCN transcription, altered 12464629 1 1 0 +CDC27 CDC27 Cell cycle regulation P30260 996 17q21.32 human S821-p 23010415 TQLHAAEsDEF____ molecular association, regulation MCPH1(INDUCES) 22139841 1 0 0 +TRPC3 TRPC3 iso3 Channel, cation; Membrane protein, integral; Membrane protein, multi-pass Q13507-3 7222 4q27 human T11-p 458335 SPSLRRMtVMREKGR activity, inhibited 14983059; 16331690 2 0 0 +Gabrg2 GABRG2 Channel, chloride; Channel, ligand-gated; Membrane protein, integral; Membrane protein, multi-pass; Transporter; Transporter, ion channel P22723 14406 11 A5|11 24.8 cM mouse Y413-p 455818 ERDEEYGyECLDGKD Neur_chan_memb activity, induced; receptor internalization, altered 19903874 7 0 0 spatial object recognition in mice +FHOD1 FHOD1 Actin-binding Q9Y613 29109 16q22.1 human S498-p 1984218 PAARTPQsPAPCVLL intracellular localization cytoskeletal reorganization 31794718 1 32 8 F-actin bundling and nuclear movement +TP63 p63 DNA-binding; Transcription factor Q9H3D4 8626 3q28 human Y290-p 10359106 RQSVLVPyEPPQVGT P53 protein stabilization 19783996 1 0 0 +TGFBR2 TGFBR2 EC 2.7.11.30; KINASE; Kinase, protein; Membrane protein, integral; Oncoprotein; Protein kinase, Ser/Thr (receptor); Protein kinase, TKL P37173 7048 3p24.1 human K556-ne 27581511 GRSCSEEkIPEDGSL protein stabilization; ubiquitination 23290524 1 0 0 antagonizes its ubiquitination +ELAVL1 HuR RNA-binding Q15717 1994 19p13.2 human T118-p 474554 SGLPRTMtQKDVEDM RRM_1 molecular association, regulation; intracellular localization RNA splicing, induced; RNA stability, induced; transcription, induced; RNA stability, altered p21Cip1(INDUCES) RNA(INDUCES) 17317627; 19528229; 21862584; 24865968; 24968827 6 0 3 regulates DUSP1 mRNA and protein expression +PXN PXN Adaptor/scaffold; Cell adhesion; Cytoskeletal; Motility/polarity/chemotaxis P49023 5829 12q24.23 human S258-p 465488 TQQQTRIsASSATRE molecular association, regulation TACE(DISRUPTS) 23317503 1 32 14 Inhibits lipid raft transfer +Scn10a SCN10A Channel, sodium; Membrane protein, integral; Membrane protein, multi-pass Q62968 rat S1452-p 25126701 NAMKKLGsKKPQKPI activity, induced 22426212 1 0 0 increase Channel function +RECQL4 RECQL4 EC 3.6.4.12; Helicase O94761 9401 8q24.3 human K385-ac 7106308 AWKQKWRkKGECFGG intracellular localization 19299466 1 0 0 accumulates in the cytoplasm +PA2G4 Ebp1 Nuclear receptor co-regulator; Nucleolus; Transcription, coactivator/corepressor Q9UQ80 5036 12q13.2 human K298-sm 11539304 MGVVECAkHELLQPF Peptidase_M24 sumoylation; protein stabilization; intracellular localization carcinogenesis, inhibited; cell growth, inhibited; transcription, inhibited 19946338 1 0 0 mutation of either site abolishes sumoylation at other site +GSK3B GSK3B EC 2.7.11.1; EC 2.7.11.26; KINASE; Kinase, protein; Protein kinase, CMGC; Protein kinase, Ser/Thr (non-receptor) P49841 2932 3q13.33 human S21-p 456055 CKPVQQPsAFGSMKV carcinogenesis, inhibited; apoptosis, induced 33755959 7 1 9 +Pxn PXN Adaptor/scaffold; Cell adhesion; Cytoskeletal; Motility/polarity/chemotaxis Q66H76 360820 12q16 rat Y31-p 448785 FLSEEPPySYPTGNH activity, induced; molecular association, regulation cell motility, altered DOCK1(INDUCES); CRK(INDUCES) 15308668 49 8 64 activation of Rac1 +EIF3A eIF3-theta RNA-binding; Translation; Translation initiation Q14152 8661 10q26.11 human S1364-p 487404 RAEKDREsLRRTKNE molecular association, regulation transcription, induced; translation, induced; signaling pathway regulation eIF4G(INDUCES) 30012863 1 3 37 PKC-Raf-ERK signaling +Met Met EC 2.7.10.1; KINASE; Kinase, protein; Membrane protein, integral; Oncoprotein; Protein kinase, TK; Protein kinase, tyrosine (receptor) P16056 17295 6 A2|6 7.83 cM mouse Y1354-p 448473 YVHVNATyVNVKCVA molecular association, regulation cell motility, altered; cytoskeletal reorganization GRB2(INDUCES); PIK3C2A(INDUCES); GAB1(INDUCES); SHC1(INDUCES) 10069803; 7708691 23 4 122 activates cell mobility +DNM1L DRP1 Apoptosis; EC 3.6.5.5; Endoplasmic reticulum; Hydrolase; Microtubule-binding; Mitochondrial; Motor O00429 10059 12p11.21 human K608-sm 9859920 LLAEEKSkPIPIMPA activity, induced; intracellular localization 19638400 1 0 0 sumoylation is linked to its GTPase activity cycle, and influenced by DRP1 localization +SMN1 SMN RNA processing; RNA-binding Q16637 6606 5q13.2 human S187-p 9316349 SDNIKPKsAPWNSFL SMN molecular association, regulation SIP1(DISRUPTS); GEMIN8(DISRUPTS) 21609790 1 5 0 +Kcnb1 Kv2.1 Channel, cation; Channel, ligand-gated; Channel, potassium; Membrane protein, integral; Membrane protein, multi-pass P15387 25736 3q42 rat S567-p 473554 LEMSSMPsPVAPLPA Kv2channel activity, inhibited 16917065 6 6 0 +LRRC8A LRRC8A Membrane protein, integral; Membrane protein, multi-pass Q8IWT6 56262 9q34.11 human S217-p 471190 PMLQRTKsRIEQGIV Pannexin_like activity, induced 34083438 1 28 8 +ADAM22 ADAM22 Cell adhesion; Membrane protein, integral; Motility/polarity/chemotaxis Q9P0K1 53616 7q21.12 human S857-p 469109 RFRPRSNsTETLSPA protein stabilization; molecular association, regulation; intracellular localization 14-3-3 beta(INDUCES); 14-3-3 theta(INDUCES); 14-3-3 zeta(INDUCES); 14-3-3 epsilon(INDUCES); 14-3-3 gamma(INDUCES); 14-3-3 eta(INDUCES) 16868027 2 15 74 +GATAD2A GATAD2A Transcription factor Q86YP4 54815 19p13.11 human K30-sm 3755612 DVESKKIkMERGLLA molecular association, regulation transcription, inhibited HDAC1(INDUCES) 16738318 1 0 0 +CDCA5 CDCA5 Cell cycle regulation Q96FF9 113130 11q13.1 human S21-p 3208968 RSGPRAPsPTKPLRR molecular association, regulation cell cycle regulation H2A.1(DISRUPTS); SMC3(DISRUPTS) 21878504 2 19 0 +CD6 CD6 Cell surface; Membrane protein, integral P30203 923 11q12.2 human S484-p 28095002 DSDSGSDsDYEHYDF phosphorylation signaling pathway regulation 23711376 1 0 0 ERK1/2 phosphorylation, MAPK pathway activation +RUNX1 AML1 DNA-binding; Oncoprotein; Transcription factor Q01196 861 21q22.12 human S266-p 454400 QYLGSIAsPSVHPAT activity, induced; molecular association, regulation; phosphorylation transcription, altered; cell growth, altered CBFB(INDUCES) 18695000; 8668214 7 3 28 +ZEB1 TCF8 C2H2-type zinc finger protein; DNA-binding; Motility/polarity/chemotaxis; Transcription, coactivator/corepressor P37275 6935 10p11.22 human S585-p 36552500 GDGNLSPsQPPLKNL protein stabilization DNA repair, induced 25086746 1 0 0 +PHF2 PHF2 DEMETHYLASE; Demethylase; EC 1.14.11.-; Nucleolus O75151 5253 9q22.31 human S899-p 4169511 RSKKRKGsDDAPYSP molecular association, regulation transcription, induced Mrf-2(INDUCES) DNA(INDUCES) 21532585 1 35 8 demethylation of Mrf-2 K336, complex is then targeted to promoters and removes repressive H3K9m2 +Pxn PXN Adaptor/scaffold; Cell adhesion; Cytoskeletal; Motility/polarity/chemotaxis Q8VI36 19303 5 F|5 56.1 cM mouse Y181-p 448898 PGALSPLyGIPENNT Paxillin apoptosis, inhibited 30604146 5 4 22 +TBCB TBCB Chaperone; Cytoskeletal; Motility/polarity/chemotaxis Q99426 1155 19q13.12 human S65-p 455784 GVDDKFYsKLDQEDA Ubiquitin_2 cytoskeletal reorganization 15831477; 18048340 2 0 0 +ATG13 ATG13 Autophagy; Vesicle O75143 9776 11p11.2 human S356-p 34499855 TETVSNSsEGRASPH carcinogenesis, inhibited; autophagy, induced; transcription, altered 34482636; 34604061; 35035775; 35182693 4 1 0 +MTF1 MTF1 C2H2-type zinc finger protein; Transcription factor Q14872 4520 1p34.3 human T254-p 25300735 RKHIRTHtGEKPFRC intracellular localization transcription, inhibited 24962574 1 0 2 +TNNI3 TNNI3 Actin-binding; Motility/polarity/chemotaxis; Motor P19429 7137 19q13.42 human S23-p 448423 PAPIRRRsSNYRAYA Troponin-I_N activity, induced; molecular association, regulation; activity, inhibited cytoskeletal reorganization TNNC1(DISRUPTS) 15134451; 24116014; 24585778; 27557662; 28018230; 8543035 68 11 11 increased myofilament length ; muscle contraction +Ctnnd1 CTNND1 Actin-binding; Adaptor/scaffold; Cell adhesion; G protein regulator, misc.; Motility/polarity/chemotaxis P30999 12388 2 D|2 49.45 cM mouse Y228-p 449648 YPGGSDNyGSLSRVT molecular association, regulation carcinogenesis, induced; cell growth, induced CDH1(INDUCES); RHOA(INDUCES) 17194753; 26067913 8 45 1087 +NINL Nlp Cell cycle regulation; Microtubule-binding Q9Y2I6 22981 20p11.21 human S448-p 15668107 QGYRERLsLLRSEVE intracellular localization cell cycle regulation 20864540 1 1 0 +LEPR LEPR Membrane protein, integral; Receptor, cytokine P48357 3953 1p31.3 human K891-ub 1872271905 AQGLNFQkPETFEHL receptor internalization, induced endocytosis, induced 16482222 1 0 0 +Hnf4a HNF4 alpha DNA-binding; Nuclear receptor; Transcription factor P49698 15378 2 H3|2 84.32 cM mouse S265-p 63076101 LAEMSRVsIRILDEL Hormone_recep molecular association, regulation SSU72(INDUCES) 34616001 2 1 0 +Aatk Lmr1 EC 2.7.11.1; KINASE; Kinase, protein; Membrane protein, integral; Protein kinase, Ser/Thr (non-receptor); Protein kinase, TK; Protein kinase, tyrosine (receptor) Q80YE4 11302 11|11 E2 mouse S606-p 456514 HSHRRQGsPCPSRSP apoptosis, induced 16100393 1 0 0 +CASP8 CASP8 Apoptosis; EC 3.4.22.61; Protease Q14790 841 2q33.1 human S305-p 31894302 IYQLMDHsNMDCFIC Peptidase_C14 protein processing apoptosis, inhibited 24484936 1 0 0 +EIF2AK2 PKR EC 2.7.10.2; EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, Other; Protein kinase, Ser/Thr (non-receptor); Protein kinase, tyrosine (non-receptor); Translation P19525 5610 2p22.2 human Y293-p 458273 HRIDGKTyVIKRVKY Pkinase enzymatic activity, induced translation, altered; cell growth, altered 16373505 1 0 0 +Pkd2 PKD2 Channel, cation; Membrane protein, integral; Membrane protein, multi-pass O35245 18764 5 E5|5 50.68 cM mouse S827-p 4696848 HSSRRRGsISSGVSY activity, inhibited 22518003 3 5 0 Negative regulation of flow-induced Ca2+ entry +Slc6a5 SLC6A5 Membrane protein, integral; Membrane protein, multi-pass; Transporter; Transporter, SLC family P58295 171148 1q22 rat K773-ub 31914107 QHRGERYkNMIDPLG protein degradation; ubiquitination; intracellular localization endocytosis, induced; transcription, altered 23484054; 31628376 2 0 0 LNX2 mediated degradation was slower and seen after 48 hours, PKC regulation of SLC6A5 activity, modulation in the glycine transport activity of SLC6A5 +INCENP INCENP iso2 Cell cycle regulation; EC 2.7.11.1 Q9NQS7-2 3619 11q12.3 human R887-m1 50613405 SKPRYHKrTSSAVWN cell cycle regulation; cell growth, induced 26460953 1 1 0 growth of cancer cells +Hcn2 HCN2 Channel, cation; Membrane protein, integral; Membrane protein, multi-pass O88703 15166 10|10 C1 mouse K669-sm 63108401 AIIQEIVkYDREMVQ activity, induced 28127275 1 0 0 increases HCN2 channel surface expression and In G-max +Scn2a SCN2A Channel, sodium; Membrane protein, integral; Membrane protein, multi-pass P04775 24766 3q21 rat S554-p 452015 TYEKRFSsPHQSLLS activity, inhibited 12359152 2 8 2 +BECN1 beclin 1 Adaptor/scaffold; Autophagy; Membrane protein, peripheral Q14457 8678 17q21.31 human S295-p 27156801 FRLGRLPsVPVEWNE APG6 molecular association, regulation; intracellular localization; activity, inhibited cell cycle regulation; carcinogenesis, induced; autophagy, inhibited 14-3-3 beta(INDUCES); K18(INDUCES); Vimentin(INDUCES); PIK3C3(INDUCES) 23112296; 34077419 4 0 0 +SPTLC2 SPTLC2 EC 2.3.1.50; Lipid Metabolism - sphingolipid; Membrane protein, integral; Transferase O15270 9517 14q24.3 human S384-p 38520203 FTKSFGAsGGYIGGK Aminotran_1_2 enzymatic activity, induced 25567748 1 0 0 +PXN PXN iso2 Adaptor/scaffold; Cell adhesion; Cytoskeletal; Motility/polarity/chemotaxis P49023-2 5829 12q24.23 human S272-p 465466 ELDELMAsLSDFKFM molecular association, regulation; intracellular localization cell motility, altered; cytoskeletal reorganization; cell adhesion, altered GIT1(INDUCES); GIT1(DISRUPTS); ARHGEF6(INDUCES) 16717130; 18664639; 18676874; 18986306; 20406887 12 12 0 critical for OxPAPC-induced pulmonary endothelial barrier protection; mediates focal-adhesion disassembly +MACF1 ACF7 Actin-binding; Cytoskeletal; Motility/polarity/chemotaxis Q9UPN3 23499 1p34.3 human S7318-p 18507010 RPGSRAGsRAGSRAS intracellular localization cell motility, induced; cytoskeletal reorganization 21295697 1 2 0 inhibits localization along microtubules, alters organization of microtubules, regulates skin wound repair, SC migration +MTOR mTOR Autophagy; EC 2.7.11.1; KINASE; Kinase, protein; Motility/polarity/chemotaxis; Protein kinase, Ser/Thr (non-receptor); Protein kinase, atypical P42345 2475 1p36.22 human S2159-p 20473601 RIQSIAPsLQVITSK molecular association, regulation; enzymatic activity, induced; phosphorylation cell cycle regulation; cell growth, induced; transcription, induced; signaling pathway regulation Raptor(DISRUPTS) 21576368; 33411856 3 1 1 phosphorylation increases the sensitivity and duration of insulin-stimulated mTORC1 signaling; Increased phosphorylation of itself at S2481 and of S6K1 and 4EBP1; induces autophosphorylation of itself, promotes mTORC1 signaling +Ulk1 ULK1 Autophagy; EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, Other; Protein kinase, Ser/Thr (non-receptor) O70405 22241 5|5 F mouse K606-ac 27850503 RPLRGSPkLPDFLQR enzymatic activity, induced autophagy, induced 22717509 2 1 0 +EGFR EGFR EC 2.7.10.1; KINASE; Kinase, protein; Membrane protein, integral; Oncoprotein; Protein kinase, TK; Protein kinase, tyrosine (receptor) P00533 1956 7p11.2 human K757-ub 1065308 ATSPKANkEILDEAY PK_Tyr_Ser-Thr receptor recycling, inhibited; protein degradation 16543144; 17940017 2 4 0 +PTK2 FAK EC 2.7.10.2; KINASE; Kinase, protein; Protein kinase, TK; Protein kinase, tyrosine (non-receptor) Q05397 5747 8q24.3 human Y577-p 447890 YMEDSTYyKASKGKL PK_Tyr_Ser-Thr enzymatic activity, induced; phosphorylation carcinogenesis, induced; cell differentiation, altered; cell growth, induced; cell motility, induced; cytoskeletal reorganization; cell adhesion, altered; transcription, altered 15735019; 17088251; 18437915; 23716717; 35999654 88 40 1747 +H3C14 HIST2H3A/C/D DNA-binding Q71DI3 126961 1q21.2 human K23-ac 18465114 PRKQLATkAARKSAP Histone chromatin organization, altered; transcription, induced 20075197 1 5 63 +Crtc2 TORC2 Transcription, coactivator/corepressor Q3U182 74343 3|3 F1 mouse S70-gl 10902812 RSSHYGGsLPNVNQI TORC_N activity, induced; molecular association, regulation; intracellular localization; phosphorylation 14-3-3 beta(DISRUPTS) 18323454 1 1 0 inhibits phosphorylation of its own site +TUBB3 TUBB3 Cytoskeletal; Motility/polarity/chemotaxis Q13509 10381 16q24.3 human Y340-p 464858 IQSKNSSyFVEWIPN Tubulin_C protein stabilization; intracellular localization cytoskeletal reorganization 35631517 1 18 369 +COP1 COP1 EC 6.3.2.-; EC 6.3.2.19; Ligase; UBIQUITIN LIGASE; Ubiquitin conjugating system; Ubiquitin ligase Q8NHY2 64326 1q25.1-q25.2 human K294-ac 1881312002 SVLEEDIkRVEEMSG protein degradation cell growth, induced; apoptosis, inhibited 33995658 1 0 0 decreases ?-catenin protein degradation and enhances ?-catenin stability, MYST3 regulates apoptosis by COP1 acetylation and stabling ?-catenin +Aicda AID EC 3.5.4.38; Hydrolase Q9WVE0 11628 6|6 F1 mouse S3-p 20660600 _____MDsLLMKQKK activity, inhibited 21135131 2 0 0 decreased class switching, decreased hypermutation, and decreased translocation frequency +SPIN1 SPIN1 DNA-binding; Nucleolus Q9Y657 10927 9q22.1 human S109-p 24976101 LNKDERVsALEVLPD molecular association, regulation carcinogenesis, induced; cell growth, induced; transcription, induced; signaling pathway regulation TCF4(INDUCES) 22258766 1 0 0 induces WNT/TCF signaling +ETV6 Tel DNA-binding; Motility/polarity/chemotaxis; Oncoprotein; Transcription factor P41212 2120 12p13.2 human Y314-p 454814 SHREDLAyMNHIMVS activity, induced; molecular association, regulation GRB2(INDUCES) 12149229 1 1 1 RAS activation +Rptor Raptor Adaptor/scaffold Q8K4Q0 74370 11|11 E2 mouse K840-ac 50792300 VLNSIAYkATVNARP phosphorylation transcription, altered; signaling pathway regulation 26357899 1 1 0 induces S792 phosphorylation; inhibits mTORC1 signaling +Prkd1 PRKD1 Autophagy; EC 2.7.11.13; KINASE; Kinase, protein; Motility/polarity/chemotaxis; Protein kinase, CAMK; Protein kinase, Ser/Thr (non-receptor) Q9WTQ1 85421 6q22 rat S748-p 448590 GEKSFRRsVVGTPAY Pkinase enzymatic activity, induced 11410586 56 49 53 +ESR2 ER-beta DNA-binding; Nuclear receptor Q92731 2100 14q23.2-q23.3 human S87-p 447915 WPTPGHLsPLVVHRQ ERbeta_N activity, induced 15862947 3 0 0 +Myocd myocardin Cell development/differentiation; Transcription factor Q8VIM5 214384 11|11 B3 mouse S462-p 3627507 TSSSPPIsPASSDLS transcription, inhibited 16141410 1 0 0 +Tom1l1 Srcasm Adaptor/scaffold Q923U0 71943 11 D|11 55.47 cM mouse Y441-p 451209 DLQPPNYyEVMEFDP molecular association, regulation cell growth, altered PIK3R1(INDUCES) 11711534; 17046829 2 1 5 mutation of this site promotes hyperproliferative phenotype +TRPV4 TRPV4 Channel, cation; Membrane protein, integral; Membrane protein, multi-pass Q9HBA0 59341 12q24.11 human S189-p 10272404 DEEFREPsTGKTCLP activity, induced 19661060 1 0 0 +FGFR3 FGFR3 EC 2.7.10.1; KINASE; Kinase, protein; Membrane protein, integral; Protein kinase, TK; Protein kinase, tyrosine (receptor) P22607 2261 4p16.3 human Y770-p 2036700 LSAPFEQySPGGQDT cell growth, altered 11294897 1 0 0 Y770F mutation increases the transforming activity of FGFR3 +PAK2 PAK2 EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, STE; Protein kinase, Ser/Thr (non-receptor) Q13177 5062 3q29 human T169-p 471473 TEAPAVVtEEEDDDE phosphorylation cell cycle regulation; carcinogenesis, induced; cell growth, induced; signaling pathway regulation 32483448 1 30 15 induces phosphorylation of mEK and ERK, induces MAPK signaling pathway +VIM Vimentin Cytoskeletal; Motility/polarity/chemotaxis P08670 7431 10p13 human S55-p 476052 TSRSLYAsSPGGVYA Filament_head molecular association, regulation cytoskeletal reorganization IDE(INDUCES) 19584300 4 23 30 intermediate filament disassembly +Ahrr AHRR Transcription factor Q3U1U7 11624 13|13 C1 mouse K660-sm 6423502 DCRAPIVkREPLDSP molecular association, regulation transcription, inhibited ANKRA2(INDUCES); HDAC5(INDUCES); HDAC4(INDUCES) 19251700 1 2 0 +Gja1 GJA1 Channel, misc.; Membrane protein, integral; Membrane protein, multi-pass; Motility/polarity/chemotaxis P23242 14609 10 B4|10 28.64 cM mouse S325-p 449992 NRMGQAGsTISNSHA Connexin43 molecular association, regulation; intracellular localization cytoskeletal reorganization; signaling pathway regulation; endocytosis, inhibited TUBB(INDUCES) 16882687; 21527737; 31189653; 36206047 10 14 0 +FHL2 FHL2 Motility/polarity/chemotaxis; Nuclear receptor co-regulator; Transcription, coactivator/corepressor Q14192 2274 2q12.2 human Y176-p 23106943 ITTGGVTyREQPWHK LIM cell cycle regulation; cell growth, inhibited 33932144 1 1 6 +TRIM29 TRIM29 Transcription factor; UBIQUITIN LIGASE; Ubiquitin ligase Q14134 23650 11q23.3 human K116-ac 13362607 LQLGAAKkPPVTFAE molecular association, regulation cell cycle regulation; carcinogenesis, induced; apoptosis, inhibited; transcription, inhibited p53(INDUCES) 20368352 1 1 0 interaction of TRIM29 with p53 inhibits p53 binding to p21 promoter +RAF1 RAF1 EC 2.7.11.1; KINASE; Kinase, protein; Oncoprotein; Protein kinase, Ser/Thr (non-receptor); Protein kinase, TKL P04049 5894 3p25.2 human S471-p 456813 IIHRDMKsNNIFLHE PK_Tyr_Ser-Thr molecular association, regulation; enzymatic activity, induced MEK1(INDUCES) 16093354; 18775988 2 2 0 +Grm5 mGluR5 iso2 GPCR, family 3; Membrane protein, integral; Membrane protein, multi-pass; Receptor, GPCR P31424-2 24418 1q32 rat S901-p 4213805 QHLWQRLsVHINKKE receptor internalization, induced; protein degradation; molecular association, regulation; intracellular localization endocytosis, induced Calmodulin(DISRUPTS) 18715999; 23152621; 36087841 3 0 1 +H4c2 H4 DNA-binding P62806 326620 13|13 A3.1 mouse K20-m2 465128 GGAKRHRkVLRDNIQ CENP-T_C chromatin organization, altered 19434510 30 16 1 regulation of senescence-related epigenetics modification +Ptpn2 PTPN2 EC 3.1.3.48; Motility/polarity/chemotaxis; PHOSPHATASE; Protein phosphatase, tyrosine (non-receptor) Q06180 19255 18|18 E1 mouse S304-p 451134 LSPICDHsQNRVMVE phosphorylation; enzymatic activity, induced carcinogenesis, induced; apoptosis, inhibited 37000627 2 33 15 dephosphorylates CD3Z +LAT2 LAB Adaptor/scaffold; Membrane protein, integral Q9GZY6 7462 7q11.23 human Y193-p 450645 EDEESEDyQNSASIH LAT2 molecular association, regulation cell differentiation, altered GRB2(INDUCES); PLCG1(INDUCES) 14722116; 17993265 3 8 151 +HNRNPK hnRNP K RNA splicing; RNA-binding; Spliceosome P61978 3190 9q21.32 human S284-p 448185 RRDYDDMsPRRGPPP molecular association, regulation; intracellular localization translation, altered; cell growth, induced; transcription, induced; transcription, inhibited PPP1CA(INDUCES); TDP-43(INDUCES) 11231586; 16564677; 24236111; 25410660; 26804170 7 102 184 localized to nuclear matrix +MAVS MAVS Adaptor/scaffold; Membrane protein, integral Q7Z434 57506 20p13 human T328-gl 1872691003 TVPSKLPtSSKPPGA phosphorylation 31461653 1 1 0 positively regulates phosphorylation of S442 (data from MAVS 7A mutant) +Pdk1 PDHK1 EC 2.7.11.2; KINASE; Kinase, protein; Mitochondrial; Protein kinase, Ser/Thr (non-receptor); Protein kinase, atypical Q8BFP9 228026 2|2 C3 mouse Y136-p 11057941 AEDAKTIyEFTDTVI BCDHK_Adom3 molecular association, regulation cell growth, induced DLAT(INDUCES) 22195962 1 0 3 Y to F mutants show decreased proliferation under hypoxia and increased oxidative phosphorylation. +EPB41 EPB41 iso4 Cytoskeletal P11171-4 2035 1p35.3 human S312-p 455112 QAQTRQAsALIDRPA FA molecular association, regulation; protein conformation cytoskeletal reorganization XK(INDUCES); SPTA1(DISRUPTS); DARC(INDUCES); GPC1(INDUCES) 21542582 2 5 4 interactions are induced by phosphorylation of either of the sites +Dck DCK EC 2.7.1.74; Kinase, other; Nucleotide Metabolism - purine; Nucleotide Metabolism - pyrimidine P43346 13178 5|5 E1 mouse S74-p 456305 EFEELTTsQKSGGNV dNK activity, induced; enzymatic activity, induced DNA repair, induced; signaling pathway regulation 25101980 16 28 92 Salvage pathway, induce dCTP production, pool size and influences in T-cell development.Regulation of genome stability +DOK1 DOK1 Adaptor/scaffold; Motility/polarity/chemotaxis Q99704 1796 2p13.1 human Y362-p 448367 DPKEDPIyDEPEGLA protein degradation; molecular association, regulation; ubiquitination; activity, inhibited; phosphorylation signaling pathway regulation CBLL1(INDUCES); RASA1(INDUCES); NCK1(INDUCES) 11551902; 22252131; 34145060 9 27 497 regulates TCR/CD28 signaling +Bmpr1a BMPR1A EC 2.7.11.30; KINASE; Kinase, protein; Membrane protein, integral; Protein kinase, Ser/Thr (receptor); Protein kinase, TKL P36895 12166 14 B|14 20.81 cM mouse Y453-p 3712679 TGGIVEEyQLPYYNM PK_Tyr_Ser-Thr molecular association, regulation cell growth, induced; signaling pathway regulation BMPR2(INDUCES); TAB1(DISRUPTS) 22729085 1 1 0 regulation of BMP downstream pathways-Erk1/2 and Smad1 activation, regulates life span of osteoblasts (expansion) +LIG1 LIG1 DNA repair, damage; EC 6.5.1.1; Ligase P18858 3978 19q13.33 human K192-ub 59175204 PKPLKTSkAETPTES protein degradation 27573245 1 1 0 +ESRRA ERR1 DNA-binding; Nuclear receptor; Transcription regulation P11474 2101 11q13.1 human K162-ac 15211511 RGGRQKYkRRPEVDP molecular association, regulation transcription, inhibited DNA(DISRUPTS) 20484414 1 0 0 +Stat1 STAT1 DNA-binding; Transcription factor P42225 20846 1 C1.1|1 26.81 cM mouse K379-ub 27211085 NTVKGFRkFNILGTH STAT_bind molecular association, regulation transcription, inhibited DNA(DISRUPTS) 29242538 1 4 0 ubiquitylation promotes dephosphorylation of STAT1/STAT2, and negatively regulates antiviral responses +Notch1 Notch 1 Membrane protein, integral; Motility/polarity/chemotaxis; Oncoprotein; Receptor, misc.; Transcription factor Q01705 18128 2 A3|2 18.91 cM mouse R2262-m2 56852001 AFEPPPPrLSHLPVA activity, induced; protein degradation; ubiquitination transcription, induced 25805888 1 1 0 +Sp1 SP1 C2H2-type zinc finger protein; DNA-binding; Transcription factor Q01714 24790 7q36 rat T454-p 448226 SGPIIIRtPTVGPNG transcription, induced 21115498 7 0 0 induced by carbon monoxide +EIF4ENIF1 4E-T Karyopherin; Nuclear import; Translation Q9NRA8 56478 22q12.2 human S752-p 26392102 PSADRDSsPTTNSKL molecular association, regulation 4E-T(INDUCES) 22966201 1 4 0 required for processing bodies (PBs or P bodies) assembly +VIL1 Villin Actin-binding; Motility/polarity/chemotaxis P09327 7429 2q35 human Y256-p 454007 LKAALKLyHVSDSEG molecular association, regulation; intracellular localization cytoskeletal reorganization ACTB(INDUCES) 12269817; 15342783 2 0 0 +YY1 YY1 C2H2-type zinc finger protein; Cell development/differentiation; Transcription factor P25490 7528 14q32.2 human T378-p 1218234 RTHVRIHtGDRPYVC molecular association, regulation; intracellular localization DNA(DISRUPTS) 19793915 1 11 38 in mitotic cells +ARHGAP24 ARHGAP24 GAP; GAP, Rac/Rho; Motility/polarity/chemotaxis Q8N264 83478 4q21.23-q21.3 human S437-p 12518706 SGIVTNGsFSSSNAE activity, induced cytoskeletal reorganization 16862148 1 3 0 membrane blebbing +SNPH syntaphilin iso2 Membrane protein, integral; Vesicle O15079-2 9751 20p13 human S59-p 50800758 SRRTSAGsRRRTSPP cell growth, induced 34087103 1 2 0 +MEF2A MEF2A DNA-binding; Motility/polarity/chemotaxis; Transcription factor Q02078 4205 15q26.3 human K403-sm 1922100 TNQNISIkSEPISPP cell differentiation, induced; transcription, inhibited 16484498; 16563226 2 0 0 +AXIN2 axin 2 Adaptor/scaffold Q9Y2T1 8313 17q24.1 human S311-p 53439300 SDALTDDsMSMTDSS protein degradation; protein stabilization; phosphorylation cell cycle regulation; carcinogenesis, inhibited; cell growth, inhibited; transcription, inhibited; signaling pathway regulation 26438599 1 0 0 Negatively regulates Wnt/beta-catenin pathway, increase binding between GSK3beta and beta-catenin, induces phosphorylation and degradation of beta-catenin, and inhibits Cdc20-mediated degradation of axin2 +MYB Myb DNA-binding; Oncoprotein; Transcription factor P10242 4602 6q23.3 human K503-sm 486351 EDLQDVIkQESDESG Cmyb_C intracellular localization transcription, inhibited 12631292 5 0 0 +PSIP1 LEDGF Motility/polarity/chemotaxis; Transcription, coactivator/corepressor O75475 11168 9p22.3 human K250-sm 13875712 KPRKEPDkKEGKKEV protein degradation transcription, inhibited 20382164 1 0 0 +GSK3B GSK3B EC 2.7.11.1; EC 2.7.11.26; KINASE; Kinase, protein; Protein kinase, CMGC; Protein kinase, Ser/Thr (non-receptor) P49841 2932 3q13.33 human Y216-p 448569 RGEPNVSyICSRYYR Pkinase protein stabilization; molecular association, regulation; intracellular localization; protein conformation; phosphorylation; enzymatic activity, induced apoptosis, altered; carcinogenesis, inhibited; apoptosis, induced; cell motility, inhibited; transcription, induced; transcription, altered; cell growth, altered TCF4(INDUCES); axin 1(DISRUPTS) 10995469; 12522140; 12900420; 14561750; 15020233; 17188038; 17318191; 18701488; 18949077; 21105670; 26755559; 33388549; 33829789; 33890983; 34966427; 35339896 98 128 4206 regulates localization and degradation of Snail +Ldb3 LDB3 Cytoskeletal Q9JKS4 24131 14|14 B mouse S296-p 28850313 EEALRRSsTPIEHAP phosphorylation cytoskeletal reorganization; signaling pathway regulation 23996002 1 0 0 facilitated PKA-mediated phosphorylation, sarcomere signaling center +HDAC4 HDAC4 DEACETYLASE; Deacetylase; EC 3.5.1.98; Hydrolase; Nuclear receptor co-regulator; SUMO LIGASE P56524 9759 2q37.3 human K559-sm 2793919 AQAGVQVkQEPIESD protein degradation; acetylation; ubiquitination; enzymatic activity, induced apoptosis, inhibited; transcription, inhibited 12032081; 25475100 2 1 0 +HNRNPL hnRNP L RNA splicing; RNA-binding P14866 3191 19q13.2 human Y359-p 473633 HRRGPSRyGPQYGHP RRM_5 protein stabilization; intracellular localization translation, induced; translation, inhibited hnRNP A2/B1(INDUCES) 23976881; 28520992 2 2 13 +HIF1A HIF1A Autophagy; DNA-binding; Transcription factor Q16665 3091 14q23.2 human K674-ac 14790000 ASPNRAGkGVIEQTE molecular association, regulation carcinogenesis, induced; transcription, induced p300(INDUCES) 20620956 3 2 0 +CTCF CTCF C2H2-type zinc finger protein; Transcription factor; Tumor suppressor Q08705 396274 chicken S612-p 448305 KKEDSSDsEENAEPD activity, inhibited transcription, induced; transcription, altered; cell growth, altered 11238955; 15733852 2 8 0 Phosphorylation mutant S612A inhibited transcriptional repression of transcription (CAT activity than wild-type CTCF. Phosphorylation mutant S612A showed transcriptional repression (CAT activity) not significantly different from wild-type after co-transfection with CK2. S612A also did not significanty alter growth suppression of COS7 cells in comparison with wild-type. +NEK9 NEK9 Autophagy; EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, Other; Protein kinase, Ser/Thr (non-receptor) Q8TD19 91754 14q24.3 human S944-p 4272073 GQQVGMHsKGTQTAK molecular association, regulation; enzymatic activity, induced signaling pathway regulation LC8(DISRUPTS); NEK6(INDUCES) 21454704; 23482567 2 11 0 +HSP90AA1 HSP90A Chaperone; Heat shock protein P07900 3320 14q32.31 human S595-p 31909111 VSNRLVTsPCCIVTS HSP90 activity, induced; molecular association, regulation; protein stabilization; activity, inhibited cell cycle regulation; carcinogenesis, induced; autophagy, inhibited; transcription, inhibited; signaling pathway regulation HSP90A(DISRUPTS); HSP70(DISRUPTS); P38G(INDUCES); TFEB(DISRUPTS); KRas(INDUCES) 24962213; 35941759 2 3 0 +BRAF BRAF EC 2.7.11.1; KINASE; Kinase, protein; Oncoprotein; Protein kinase, Ser/Thr (non-receptor); Protein kinase, TKL P15056 673 7q34 human T753-p 460657 YACASPKtPIQAGGY molecular association, regulation cell growth, altered RAF1(DISRUPTS) 16508002; 19933846 4 8 3 +ZAP70 ZAP70 EC 2.7.10.2; KINASE; Kinase, protein; Protein kinase, TK; Protein kinase, tyrosine (non-receptor) P43403 7535 2q11.2 human Y319-p 447587 TSVYESPySDPEELK activity, induced; molecular association, regulation; protein conformation; enzymatic activity, induced; phosphorylation transcription, induced; signaling pathway regulation; transcription, altered PLCG1(INDUCES); CD3G(DISRUPTS); Lck(INDUCES) 10037717; 10202147; 10318843; 11046020; 12648457; 26237552; 30992398; 33482200; 33531381; 34161759; 35259248 58 7 263 induces LAT phosphorylation, induces Erk and calcium signaling; induces TCR signaling; regulates TCR signaling +Oprd1 DOR-1 GPCR, family 1; Membrane protein, integral; Membrane protein, multi-pass; Receptor, GPCR P32300 18386 4 D2.3|4 64.78 cM mouse T352-p 18321900 LRRPRQAtTRERVTA intracellular localization 21220103 1 0 0 +Mlxipl ChREBP Transcription factor Q8VIP2 171078 12q12 rat S568-p 451262 TLLRPPEsPDAVPEI activity, inhibited transcription, inhibited DNA(DISRUPTS) 11724780 1 5 0 +COPS6 COPS6 Cell cycle regulation Q7L5N1 10980 7q22.1 human S60-p 27166600 DHWIRMRsQEGRPVQ JAB protein stabilization; ubiquitination cell growth, induced 23095642; 23421998; 26318036 3 0 0 phosphorylation of tis site stabilize COP56 , which in turn helps to stabilize E6AP protein/downregulates p53/promotes tumorigenesis; involved in p57 degradation; Akt phosphorylation of S60 reduced ubiquitination of COPS6. S60D mutant induces p53 degradation and enhances transformation. +LCP1 L-plastin Actin-binding; Motility/polarity/chemotaxis P13796 3936 13q14.13 human S5-p 450852 ___MARGsVSDEEMM molecular association, regulation; intracellular localization; enzymatic activity, induced carcinogenesis, induced; cell motility, induced; cell adhesion, induced; cytoskeletal reorganization; cell adhesion, altered ITGB2(NOT_REPORTED); ITGB2(INDUCES); ACTA1(INDUCES) 10446213; 16636079; 17294403; 20169155; 23001012; 26631483; 33449151; 33618712 15 49 4 induces MMP-9 activity +NR4A2 NR4A2 DNA-binding; Nuclear receptor P43354 4929 2q24.1 human K558-sm 7435500 YLSKLLGkLPELRTL Hormone_recep transcription, inhibited 19345186 1 0 0 +EGFR EGFR EC 2.7.10.1; KINASE; Kinase, protein; Membrane protein, integral; Oncoprotein; Protein kinase, TK; Protein kinase, tyrosine (receptor) P00533 1956 7p11.2 human Y1092-p 448057 TFLPVPEyINQSVPK protein degradation; molecular association, regulation; phosphorylation; enzymatic activity, induced; activity, induced; ubiquitination; intracellular localization; receptor internalization, altered; protein conformation cell cycle regulation; cell differentiation, inhibited; carcinogenesis, induced; carcinogenesis, inhibited; cell motility, induced; transcription, induced; transcription, altered; signaling pathway regulation; exocytosis, induced; cell growth, induced; apoptosis, inhibited; cell adhesion, altered; cell growth, altered RASA1(INDUCES); GRB2(INDUCES); Src(INDUCES); SHP-1(INDUCES); SOS1(INDUCES); EGFR(INDUCES); STAT3(INDUCES); CBL(INDUCES) DNA(INDUCES) 10069801; 11983694; 12631709; 12842895; 12873986; 1314835; 15192046; 15592458; 15618223; 16037379; 16729043; 2022651; 2022652; 21787862; 24430869; 26290602; 31952541; 32019812; 3263271; 33574089; 33707748; 33889303; 33947961; 34088769; 34107301; 34290403; 34367939; 34385595; 34469737; 34539858; 35157848; 35173310; 35226996; 36744428; 36988334; 7506413; 7741752; 8408058; 8490966; 8910327; 9733788 177 30 352 EGFR autophosphorylation sites modulate STAT activation. +HIPK2 HIPK2 EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, CMGC; Protein kinase, Ser/Thr (non-receptor) Q9H2X6 28996 7q34 human T880-p 29668000 QTIVIPDtPSPTVSV protein stabilization; molecular association, regulation; protein conformation; phosphorylation; enzymatic activity, induced apoptosis, induced PIN1(INDUCES) 24145406 1 0 0 +PLAGL2 PLAGL2 C2H2-type zinc finger protein; DNA-binding Q9UPG8 5326 20q11.21 human K250-ac 483054 SQELLKIkTEPVDML sumoylation transcription, induced 17551969 1 0 0 acetylation abolishes sumoylation on the same three residues, promoter-specific transcription +CHEK2 Chk2 EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, CAMK; Protein kinase, Ser/Thr (non-receptor); Tumor suppressor O96017 11200 22q12.1 human Y390-p 17534901 TLCGTPTyLAPEVLV Pkinase intracellular localization; enzymatic activity, induced 20713355 1 1 0 chromatin targeting of S372, S379, T389, singly and T383/389, T378/S379 +Zc3h12a MCPIP1 EC 3.1.-.-; Hydrolase Q5D1E7 230738 4|4 D2.2 mouse S435-p 22730005 TSQECLDsGIGSLES protein degradation; molecular association, regulation; ubiquitination; phosphorylation RNA stability, induced; transcription, induced BTRC(INDUCES) 22037600; 31072819 2 0 0 phosphorylation followed by degradation of ZC3H12A (aka regnase-1) augments IL-6 mRNA stability; induces phosphorylation of STAT3 +Stk11 LKB1 Autophagy; EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, CAMK; Protein kinase, Ser/Thr (non-receptor); Tumor suppressor Q9WTK7 20869 10|10 C1 mouse T366-p 448151 IEDGIIYtQDFTVPG protein degradation apoptosis, inhibited; DNA repair, altered 25329316; 28652249 6 0 0 improved survival of LKB1-deficient H2030 NSCLC cells to combined AZD1775 + cisplatin treatment +CENPT CENPT DNA replication Q96BT3 80152 16q22.1 human T11-p 12667377 HNPDSDStPRTLLRR CENP-T_N molecular association, regulation; intracellular localization cell cycle regulation 21529714; 25660545 3 2 0 localization of Ndc80/Hec1, controls kinetochore assembly, increases cell viability; KMN network recruitment +FBXL20 FBXL20 UBIQUITIN LIGASE; Ubiquitin ligase Q96IG2 84961 17q12 human S139-p 1875005600 DATCTSLsKFCSKLR protein degradation; molecular association, regulation carcinogenesis, inhibited; cell growth, inhibited; apoptosis, induced FBXO31(INDUCES) 34587475 1 0 0 +Casp4 CASP4 Apoptosis; EC 3.4.22.64; Protease P70343 12363 9 A1|9 2.46 cM mouse K159-ub 1877676802 NFDIIGMkGLLEDLG Peptidase_C14 protein degradation 30816303 1 0 0 +ACTN4 ACTN4 Cytoskeletal; Motility/polarity/chemotaxis O43707 81 19q13.2 human Y13-p 397383605 AANQSYQyGPSSAGN molecular association, regulation cell motility, inhibited ACTB(DISRUPTS) 29274473 1 0 0 slightly decreases binding; enhances invasion of melanoma cell line; decreases the susceptibility to m-calpain cleavage +Tbx21 TBX21 DNA-binding; Transcription factor Q9JKD8 57765 11|11 D mouse S498-p 56676120 DTKRRRIsPYPSSGD cell growth, inhibited; transcription, induced 29133416 1 1 0 IFN? transcription, attenuates colon cancer metastasis in RSK2 KO mice +FLOT2 FLOT2 Cell adhesion Q14254 2319 17q11.2 human Y163-p 475941 DVYDKVDyLSSLGKT Band_7 endocytosis, altered 19258392 4 3 36 regulates FLOT2 internalization +SAV1 SAV1 Adaptor/scaffold Q9H4B6 60485 14q22.1 human Y273-p 1870435804 CAPSVPRyDQPPPVT molecular association, regulation; protein conformation; phosphorylation signaling pathway regulation DDN(INDUCES); SAV1(DISRUPTS); MST1(DISRUPTS) 32905778 1 0 0 inhibits LATS1 phosphorylation, regulates Hippo signaling pathway +MCM4 MCM4 DNA replication; EC 3.6.4.12 P33991 4173 8q11.21 human T7-p 450000 _MSSPAStPSRRGSR activity, inhibited 12714602 2 3 0 +Lpin1 LPIN1 EC 3.1.3.4; Phosphatase, lipid Q91ZP3 14245 12 A1.1|12 7.9 cM mouse S106-p 471342 IPMYLATsPILSEGA Lipin_N intracellular localization chromatin organization, altered; transcription, induced; signaling pathway regulation 17105729; 21816276 3 4 0 SREBP pathway, regulates nuclear eccentricity +DNMT1 DNMT1 Amino Acid Metabolism - cysteine and methionine; Cell development/differentiation; EC 2.1.1.37; METHYLTRANSFERASE; Methyltransferase; Methyltransferase, DNA; Transcription regulation P26358 1786 19p13.2 human K366-ac 25171009 YLDDPDLkYGQHPPD cell cycle regulation 21947282 1 1 0 +HJURP HJURP Histone-binding; Nucleolus Q8NCD3 55355 2q37.1 human S473-p 483759 MYRGGPAsPGGLQGL molecular association, regulation; intracellular localization cell cycle regulation OIP5(DISRUPTS) 24519934 2 39 7 Mis18 binds with HJURP and specifies the centromere localization +MAPK8 JNK1 EC 2.7.11.24; KINASE; Kinase, protein; Protein kinase, CMGC; Protein kinase, Ser/Thr (non-receptor) P45983 5599 10q11.22 human Y185-p 447645 TSFMMTPyVVTRYYR Pkinase enzymatic activity, induced cell cycle regulation; carcinogenesis, induced; apoptosis, altered; carcinogenesis, inhibited; apoptosis, induced; cell motility, inhibited; transcription, induced; transcription, altered; signaling pathway regulation; cell differentiation, induced; cell growth, induced; cell adhesion, altered 10867021; 15944157; 17210579; 31575661; 33573023; 34034759; 34048499; 35790913; 35843311; 36289618; 37298039; 8137421; 9312068 270 48 1269 +PARP1 PARP1 DNA repair, damage; EC 2.4.2.30; Nuclear envelope; Nuclear receptor co-regulator; Nucleolus; Transferase P09874 142 1q42.12 human S786-p 21440501 RGGSDDSsKDPIDVN PARP_reg intracellular localization; enzymatic activity, inhibited 21922195 1 2 0 +HMGN2 HMGN2 DNA-binding P05204 3151 1p36.11 human S29-p 2574920 QRRSARLsAKPAPPK HMG14_17 intracellular localization 10739259 3 20 0 Phosphorylation facilitates localization to non-nuclear pools. +TFAM TFAM DNA-binding; Transcription regulation Q00059 7019 10q21.1 human S177-p 33402212 FQEAKGDsPQEKLKT HMG_box_2 molecular association, regulation transcription, inhibited DNA(DISRUPTS) 24768991 1 2 0 mitochondrial transcription; supression of mitochondrial biogenesis +Fzd3 FZD3 GPCR, Fz/Smo family; Membrane protein, integral; Membrane protein, multi-pass; Receptor, GPCR Q61086 14365 14 D1|14 34.09 cM mouse S588-p 18507006 KVSSYHGsLHRSRDG receptor internalization, inhibited; phosphorylation endocytosis, inhibited 21316586 1 4 0 enhances PCP signaling, regulating c-Jun phosphorylation, and affecting growth cone guidance +SULT2B1 SULT2B1 EC 2.8.2.2; Energy Metabolism - sulfur; Lipid Metabolism - androgen and estrogen; Transferase O00204 6820 19q13.33 human S348-p 21336503 REPRPNSsPSPSPGQ protein stabilization; molecular association, regulation; intracellular localization; protein conformation; enzymatic activity, induced SULT2B1(INDUCES) 21855633 1 1 1 +Kidins220 KIDINS220 Membrane protein, integral; Membrane protein, multi-pass; Protein kinase, regulatory subunit Q9EQG6 116478 6q16 rat Y1095-p 458291 PPRPPSGySQPASVC molecular association, regulation CRKL(INDUCES) 16284401 1 0 0 +Mpl MPL Membrane protein, integral; Receptor, cytokine Q08351 17480 4 D2.1|4 54.61 cM mouse Y582-p 454722 PSQPQMDyRGLQPCL activity, inhibited cell growth, altered 19996410 5 3 15 +SNU13 NHP2L1 Nucleolus; RNA splicing; RNA-binding; Spliceosome P55769 4809 22q13.2 human K33-m1 58123004 VQQSCNYkQLRKGAN Ribosomal_L7Ae molecular association, regulation L3MBTL iso4(INDUCES) 23583077 0 1 0 +STK24 MST3 EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, STE; Protein kinase, Ser/Thr (non-receptor) Q9Y6E0 8428 13q32.2 human T18-p 452058 ALNKRRAtLPHPGGS activity, induced 10644707 1 0 1 +STAT5B STAT5B DNA-binding; Oncoprotein; Transcription factor P51692 6777 17q21.2 human K701-ac 11323911 KAVDGYVkPQIKQVV phosphorylation transcription, induced 23980167 1 2 0 increases pSTAT5B at Y699 +PDE4D PDE4D iso6 EC 3.1.4.53; Nucleotide Metabolism - purine; Phosphodiesterase Q08499-6 5144 5q11.2-q12.1 human K323-sm 13310804 SIPRFGVkTEQEDVL enzymatic activity, induced 20196770 1 1 0 +AMER1 WTX iso2 Q5JTC6-2 139285 Xq11.2 human S286-p 23010401 SSLEEPHsPETGEKV WTX molecular association, regulation transcription, inhibited KEAP1(INDUCES) 22215675 1 5 0 WTX-KEAP1 interaction inhibits KEAP1-NRF2 interaction and NRF2 ubiquitination and degradation +PDGFRB PDGFRB EC 2.7.10.1; KINASE; Kinase, protein; Membrane protein, integral; Oncoprotein; Protein kinase, TK; Protein kinase, tyrosine (receptor) P09619 5159 5q32 human Y581-p 447519 SDGHEYIyVDPMQLP molecular association, regulation; phosphorylation; enzymatic activity, induced cell growth, altered RASA1(INDUCES); PLCG1(INDUCES); PIK3R1(INDUCES) 10642538; 10683371; 9454734; 9642269 6 1 0 +GFAP GFAP Cytoskeletal F1RR02 396562 pig S8-p 449618 MERRRVTsAARRSYV Filament_head neural plasticity; cell cycle regulation; cytoskeletal reorganization 1379174; 22528834 9 0 0 +Gab1 GAB1 Adaptor/scaffold; Motility/polarity/chemotaxis Q9QYY0 14388 8|8 C2 mouse Y373-p 447945 ASDTDSSyCIPPPAG molecular association, regulation cell differentiation, altered; cell growth, altered PLCG1(INDUCES) 10734310 6 15 279 +SALL4 SALL4 iso3 C2H2-type zinc finger protein; Cancer Testis Antigen (CTA); DNA-binding Q9UJQ4-2 57167 20q13.2 human K374-sm 31089511 SAVDVKPkDEAALYK protein stabilization; molecular association, regulation; intracellular localization transcription, induced Oct4(DISRUPTS) 23012367 1 0 0 +NPM1 NPM1 Nucleolus; Oncoprotein; RNA-binding; Translation P06748 4869 5q35.1 human T234-p 449024 SFKKQEKtPKTPKGP molecular association, regulation; intracellular localization cell cycle regulation; cell motility, induced; cell growth, induced; cytoskeletal reorganization ROCK2(INDUCES) RNA(DISRUPTS) 11278991; 12058066; 14670079; 26536659; 26993766; 30453269 7 21 17 stress fiber formation was enhanced, invasion and migration of HCC cells +POLB POLB DNA repair, damage; DNA replication; EC 2.7.7.7; Lyase; Transferase P06746 5423 8p11.21 human S55-p 41521701 KYPHKIKsGAEAKKL HHH_8 protein conformation; enzymatic activity, induced 30138833 3 0 0 +Cyp2b1 CYP2B6 Cofactor and Vitamin Metabolism - retinol; EC 1.14.14.1; Lipid Metabolism - arachidonic acid; Oxidoreductase; Xenobiotic Metabolism - drug metabolism - cytochrome P450; Xenobiotic Metabolism - metabolism by cytochrome P450 P00176 24300 1q21 rat S128-p 448738 WKALRRFsLATMRDF p450 enzymatic activity, inhibited; intracellular localization; protein conformation 10523294; 11745470; 12464263; 2583091 4 3 0 +CAPN2 CAPN2 EC 3.4.22.53; Motility/polarity/chemotaxis; Protease P17655 824 1q41 human S369-p 451303 DGNWRRGsTAGGCRN Calpain_III activity, inhibited cell motility, altered 11909964 2 1 2 +Casp8 CASP8 Apoptosis; EC 3.4.22.61; Protease O89110 12370 1 C1.3|1 29.19 cM mouse T265-p 21258500 KMKDRKGtDCDKEAL Peptidase_C14 enzymatic activity, inhibited; protein conformation; phosphorylation 32979304 2 1 0 induces RIP3/MLKL phosphorylation +CTPS1 CTPS EC 6.3.4.2; Ligase; Motility/polarity/chemotaxis; Nucleotide Metabolism - pyrimidine P17812 1503 1p34.2 human S571-p 457565 RDTYSDRsGSSSPDS activity, inhibited 17681942 1 35 3 +CD151 CD151 Membrane protein, integral; Membrane protein, multi-pass P48509 977 11p15.5 human K7-ub 4666605 _MGEFNEkKTTCGTV protein degradation 18713730 1 0 0 cell surface downregulation of tetraspanins +TP53BP1 53BP1 DNA repair, damage; Transcription, coactivator/corepressor Q12888 7158 15q15.3 human S1618-p 3194894 LTKAADIsLDNLVEG activity, induced; molecular association, regulation; ubiquitination; intracellular localization cell cycle regulation; chromatin organization, altered; DNA repair, inhibited RNF168(DISRUPTS) 24703952; 25607646 2 30 0 induce genome stability and Abrogates 53BP1 Foci in G1 Cells. Prevents the interaction of 53BP1 with chromatin.; localization at kinetochores +FOXO1 FOXO1A DNA-binding; Nuclear receptor co-regulator; Oncoprotein; Transcription factor Q12778 2308 13q14.11 human S298-p 471972 QFSKWPAsPGSHSND intracellular localization cell growth, induced; transcription, inhibited; transcription, altered 20061393; 23995784 6 12 30 +Septin7 SEPT7 Cell cycle regulation; Cytoskeletal; Hydrolase O55131 235072 9|9 A4 mouse T425-p 476328 EQQNSSRtLEKNKKK molecular association, regulation; intracellular localization cytoskeletal reorganization PSD-95(INDUCES) 28065648 2 56 46 required for dendritic spine formation, localizes to dendritic spines on phosphorylation +Rps6ka1 p90RSK EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, AGC; Protein kinase, Ser/Thr (non-receptor); Translation Q63531 81771 5q36 rat S221-p 447988 DHEKKAYsFCGTVEY Pkinase molecular association, regulation; intracellular localization; enzymatic activity, inhibited; phosphorylation; enzymatic activity, induced cell growth, induced; apoptosis, inhibited; translation, induced PKAR1A(DISRUPTS); PKAR1A(INDUCES) 20048145; 22130794; 35648763 10 42 95 induces eEF2K phosphorylation +Sod2 SOD2 EC 1.15.1.1; Mitochondrial; Oxidoreductase P09671 20656 17 A1|17 8.75 cM mouse K75-ac 33350042 KYHEALAkGDVTTQV Sod_Fe_N enzymatic activity, altered 28433661 0 3 0 +Cacna1b CACNA1B iso2 Channel, calcium; Membrane protein, integral; Membrane protein, multi-pass Q6XS92 257648 3p13 rat Y52-p 14080100 RIHYKDMySLLRCIA GPHH activity, inhibited 17293861 1 0 0 voltage-dependent inhibition of channel currents +USP25 USP25 DEUBIQUITINASE; EC 3.4.19.12; Protease; Ubiquitin conjugating system; Ubiquitin-specific protease Q9UHP3 29761 21q21.1 human K99-ub 7761222 IDLTGDDkDDLQRAI UIM enzymatic activity, induced 19440361 1 3 1 +Rps6 S6 Translation P62754 20104 4|4 C4 mouse S244-p 448095 LRASTSKsESSQK__ activity, induced neural plasticity; carcinogenesis, induced; carcinogenesis, inhibited; transcription, induced; transcription, altered 23361300; 26590421; 33826903; 34344824; 34819370 108 34 561 +DGKK DGKK EC 2.7.1.107; Kinase, lipid Q5KSL6 139189 Xp11.22 human Y78-p 457633 SESATELyTEPTPEP enzymatic activity, inhibited 16210324 1 0 0 +TFEB TFEB DNA-binding; Transcription factor P19484 7942 6p21.1 human S134-p 31886898 AGHVLSSsAGNSAPN MITF_TFEB_C_3_N intracellular localization 33753903 1 2 0 +MAPT Tau iso8 ACETYLTRANSFERASE; Acetyltransferase; Cytoskeletal P10636-8 4137 17q21.31 human K280-ac 25223700 GKVQIINkKLDLSNV Tubulin-binding molecular association, regulation; protein conformation; phosphorylation cytoskeletal reorganization 21427723; 28855586; 31543505; 33496017; 34966788 13 2 0 alters the H-bond is associations and strengthens the residue-residue interactions; K280 acetylation promotes formation of the beta-sheet PHF6* peptides and the formation of larger beta-sheet oligomers; could impair tau interactions with microtubules; inhibts Tau iso8 phosphorylation and microtubule binding, ameliorates amyloid-beta toxicity; induces PHF6* peptides to become more compact; K280Q mutant aggregates faster and forms longer fibrils than K18, forms seeds more slowly, binds to fibrils with marginally lower affinity, the fibrils of K289Q converts monomeric protein into fibrils slower, but monomeric tau-K18 K280Q converts into fibrils faster ; K280Q mutant caused a reduction of S202/T205 phosphorylation, reduced neuroinflammation, restored levels of N-methyl- D-aspartate receptors and post-synaptic markers compared with the parental mice, altered conformation, reduced astrogliosis and microgliosis, restored synaptic homeostasis +MAVS MAVS Adaptor/scaffold; Membrane protein, integral Q7Z434 57506 20p13 human T234-p 3204129 FQPLARStPRASRLP molecular association, regulation PLK1(INDUCES) 19546225 1 4 2 +BAP1 BAP1 DEUBIQUITINASE; EC 3.4.19.12; Protease; Tumor suppressor; Ubiquitin conjugating system; Ubiquitin-specific protease Q92560 8314 3p21.1 human T493-p 37043703 PTPSNEStDTASEIG molecular association, regulation; intracellular localization FOXK2(INDUCES); FOXK1(INDUCES) 25451922 1 0 0 +EP300 p300 ACETYLTRANSFERASE; Acetyltransferase; EC 2.3.1.48; Motility/polarity/chemotaxis; Nuclear receptor co-regulator; Transcription, coactivator/corepressor Q09472 2033 22q13.2 human S1834-p 447591 MLRRRMAsMQRTGVV molecular association, regulation transcription, induced CAF-1A(INDUCES) 16024795; 16926151 9 0 0 vorinostat recruitment of acetyl-p65 K310, phospho-p300 (Ser1834), phospho-Akt (Ser473), and RNA polymerase II formation on both cIAP2 and Bfl-1/A1 promoters +Ahr AHR DNA-binding; Transcription factor P30561 11622 12 A3|12 15.78 cM mouse S35-p 451413 EGIKSNPsKRHRDRL HLH carcinogenesis, induced; apoptosis, inhibited 35405096 2 1 0 +Slc12a1 NKCC2 Membrane protein, integral; Membrane protein, multi-pass; Transporter; Transporter, SLC family P55016 25065 3q36 rat S126-p 478420 GPKVNRPsLQEIHEQ AA_permease_N activity, induced; molecular association, regulation ANXA2(DISRUPTS) 24526686 8 2 0 Low chloride hypotonic stress enhances raft association of NKCC2 and AnxA2 +SLC9A5 NHE5 Membrane protein, integral; Membrane protein, multi-pass; Transporter; Transporter, SLC family Q14940 6553 16q22.1 human S709-p 20832304 SEEEEEEsDSSETEK molecular association, regulation; activity, inhibited endocytosis, induced ARRB1(INDUCES) 21296876 1 0 0 +Pdx1 PDX1 DNA-binding; Transcription factor P52946 18609 5 G3|5 86.84 cM mouse T231-p 13421407 PEQDCAVtSGEELLA transcription, inhibited 20339896 1 0 0 +DLG4 PSD-95 Adaptor/scaffold P78352 1742 17p13.1 human S561-p 25680400 EFPDKFGsCVPHTTR Guanylate_kin neural plasticity; cytoskeletal reorganization 22807451 2 1 0 dendritic spine morphogenesis +Tp53 p53 Activator; DNA-binding; Motility/polarity/chemotaxis; Nuclear receptor co-regulator; Transcription factor; Tumor suppressor P02340 22059 11 B3|11 42.83 cM mouse K378-ub 464657 GQSTSRHkKTMVKKV transcription, altered 15964796 10 0 0 p53K6R (K378/383/369/379/367/370/R) mutant is still ubiquitinated and shows normal stability of p53 before and after DNA damage +Atoh1 ATOH1 Cell development/differentiation; DNA-binding; Transcription factor P48985 11921 6 C1|6 30.03 cM mouse S309-p 57761909 MMAQKDLsPSLPGGI protein stabilization; ubiquitination; phosphorylation cell differentiation, inhibited; cell cycle regulation; cell growth, induced 34057742 2 2 0 inhibits phosphorylation at S328 and ubiquitinatiion +MEF2A MEF2A DNA-binding; Motility/polarity/chemotaxis; Transcription factor Q02078 4205 15q26.3 human S355-p 449934 SALQGFNsPGMLSLG activity, induced 10849446 1 0 0 +Enpp1 ENPP1 Carbohydrate Metabolism - starch and sucrose; Cofactor and Vitamin Metabolism - nicotinate and nicotinamide; Cofactor and Vitamin Metabolism - pantothenate and CoA biosynthesis; Cofactor and Vitamin Metabolism - riboflavin; EC 3.1.4.1; EC 3.6.1.9; KINASE; Membrane protein, integral; Motility/polarity/chemotaxis; Nucleotide Metabolism - purine; Phosphatase (non-protein); Phosphodiesterase Q924C3 85496 1p12 rat T238-p 451402 RPVYPTKtFPNHYSI Phosphodiest enzymatic activity, inhibited 8917428 1 7 1 +NAA50 NAA50 ACETYLTRANSFERASE; Acetyltransferase; EC 2.3.1.- Q9GZZ1 80218 3q13.31 human K34-ac 461831 FPVSYNDkFYKDVLE Acetyltransf_1 acetylation; enzymatic activity, induced 19744929 1 7 98 reduces histone acetylation and increases NAT activity, thereby increasing enzyme specificity +Tmbim1 TMBIM1 Membrane protein, integral; Membrane protein, multi-pass Q8BJZ3 69660 1|1 C3 mouse K126-ub 1873041104 TFVEPVGkYVRNNVA Bax1-I molecular association, regulation Hrs(INDUCES) 28481357 1 1 0 +HDAC2 HDAC2 DEACETYLASE; Deacetylase; EC 3.5.1.98; Nuclear receptor co-regulator; Transcription, coactivator/corepressor Q92769 3066 6q21 human S394-p 449930 EDAVHEDsGDEDGED acetylation; molecular association, regulation; enzymatic activity, inhibited; enzymatic activity, induced apoptosis, induced p53(INDUCES); HDAC1(INDUCES); FOXO3A(INDUCES); SIN3A(INDUCES); CHD-3 iso3(INDUCES) 12082111; 20388487; 25609639 6 87 52 +MEF2C MEF2C iso3 DNA-binding; Transcription factor Q06413-3 4208 5q14.3 human T300-p 448001 TPVVSVAtPTLPGQG activity, induced transcription, altered 9069290 2 0 0 +E6 HPV16 protein E6 P03126 1489078 papillomavirus T156-p 1884110701 SSRTRREtQL_____ molecular association, regulation 14-3-3 sigma(INDUCES); 14-3-3 zeta(INDUCES); 14-3-3 gamma(INDUCES) 36775199 1 0 0 +CDT1 CDT1 DNA replication; DNA-binding; Motility/polarity/chemotaxis; Oncoprotein Q9H211 81620 16q24.3 human T102-p 31889833 GQKIKKStPAAGQPP cell cycle regulation; cytoskeletal reorganization 30154187 1 1 0 regulates kTM stability +ATXN7 ataxin-7 Nucleolus; Transcription regulation O15265 6314 3p14.1 human K257-ac 11489911 RIMTPSVkVEKIHPK protein stabilization; molecular association, regulation; intracellular localization 19955365 1 0 0 regulates stability (accumulation) of ataxin-7 N-terminal cleavage fragment, colocalizes with LAMP2 a lysosomal marker, which is important in autophagy +Fadd FADD Adaptor/scaffold; Apoptosis Q61160 14082 7 F5|7 88.85 cM mouse S191-p 447653 VSKSENMsPVLRDST intracellular localization cell cycle regulation; cell growth, inhibited; apoptosis, induced; cell growth, altered 12705854; 16061179; 17553783; 18657552; 35753028 15 28 0 +Nfkbib IkB-beta Inhibitor Q60778 18036 7|7 B1 mouse S19-p 447917 DADEWCDsGLGSLGP protein degradation 10497169; 9092533 6 0 0 +MAD2L1 MAD2L1 Cell cycle regulation Q13257 4085 4q27 human S178-p 11280300 GPQFITNsEEVRLRS HORMA molecular association, regulation cell cycle regulation Mad1(DISRUPTS) 12574116 2 0 0 +Kcnj11 Kir6.2 Channel, potassium; Membrane protein, integral; Membrane protein, multi-pass P70673 rat S385-p 2103601 AKPKFSIsPDSLS__ exocytosis, altered 19357830 2 3 0 regulates insulin secretion +MDH2 MDH2 Carbohydrate Metabolism - citrate (TCA) cycle; Carbohydrate Metabolism - glyoxylate and dicarboxylate; Carbohydrate Metabolism - pyruvate; EC 1.1.1.37; Mitochondrial; Oxidoreductase P40926 4191 7q11.23 human K314-ac 466434 KVSSFEEkMISDAIP Ldh_1_C enzymatic activity, induced 20167786 0 10 8 +CBL CBL Adaptor/scaffold; EC 6.3.2.-; EC 6.3.2.19; Ligase; Motility/polarity/chemotaxis; Oncoprotein; UBIQUITIN LIGASE; Ubiquitin conjugating system; Ubiquitin ligase P22681 867 11q23.3 human Y371-p 449753 TQEQYELyCEMGSTF protein degradation; molecular association, regulation; protein conformation; phosphorylation; enzymatic activity, induced cell cycle regulation; apoptosis, altered; carcinogenesis, inhibited; apoptosis, induced; signaling pathway regulation; cell growth, altered EGFR(INDUCES); SH3KBP1(DISRUPTS); EGFR(DISRUPTS); CRK(INDUCES); PIK3R1(INDUCES) 10635327; 11448952; 11997497; 15117950; 20622007; 24469048; 33627783 8 10 81 inhibits phosphorylation at other sites, regulates RTK signaling +GFPT1 GFAT Amino Acid Metabolism - alanine, aspartate and glutamate; Carbohydrate Metabolism - amino sugar and nucleotide sugar; EC 2.6.1.16; Transferase Q06210 2673 2p13.3 human S261-p 467935 CNLSRVDsTTCLFPV enzymatic activity, induced 17941647 4 83 522 +MALT1 MALT1 Adaptor/scaffold; Apoptosis; EC 3.4.22.-; Ligase; Nuclear export; Protease; UBIQUITIN LIGASE; Ubiquitin conjugating system Q9UDY8 10892 18q21.32 human K679-ub 2134700 LSSLQKLkEHLVFTV MALT1_Ig protein degradation; molecular association, regulation IKKA(INDUCES) 17948050 1 0 0 activation of NF-kB pathway and IL-2 induction +AQP5 AQP5 Channel, misc.; Membrane protein, integral; Membrane protein, multi-pass; Transporter; Transporter, aquaporin family P55064 362 12q13.12 human S183-p 1868832800 GIYFTGCsMNPARSF MIP activity, inhibited 31277235 1 0 0 impaired water permeability through pore blockage +DCX Doublecortin Cytoskeletal; Motility/polarity/chemotaxis O43602 1641 Xq23 human S28-p 451358 SRMNGLPsPTHSAHC molecular association, regulation cell motility, induced; cell motility, altered; cytoskeletal reorganization TUBA1A(DISRUPTS); ACTB(INDUCES); Spinophilin(INDUCES) 30625347 2 1 2 +DCBLD2 DCBLD2 Cell adhesion; Membrane protein, integral Q96PD2 131566 3q12.1|3 human Y655-p 478857 GYADLDPyNSPGQEV molecular association, regulation CRKL(INDUCES) 23770091 2 4 7 +FBXW7 FBXW7 Motility/polarity/chemotaxis; Nucleolus; UBIQUITIN LIGASE; Ubiquitin conjugating system; Ubiquitin ligase Q969H0 55294 4q31.3 human S18-p 17337001 KRRRTGGsLRGNPSS molecular association, regulation; ubiquitination; protein conformation CCNE1(DISRUPTS) 28850619 2 0 0 it is inactive towards its substrate cyclin E, negatively regulates cyclin E binding by interfering with Fbw7a dimerization +FUS hnRNP P2 DNA-binding; Nuclear receptor co-regulator; Oncoprotein; RNA splicing; RNA-binding; SUMO LIGASE P35637 2521 16p11.2 human S221-p 12217071 GGRGRGGsGGGGGGG molecular association, regulation hnRNP P2(DISRUPTS) 35753345 1 5 4 +GLI3 GLI3 C2H2-type zinc finger protein; Transcription factor P10071 2737 7p14.1 human S865-p 15501379 YLSSRRSsGISPCFS protein processing transcription, inhibited 10693759 1 2 6 +HRAS HRas G protein; G protein, monomeric; G protein, monomeric, Ras; Motility/polarity/chemotaxis; Oncoprotein P01112 3265 11p15.5 human T144-p 25324400 YGIPYIEtSAKTRQG Ras protein degradation; molecular association, regulation; ubiquitination; phosphorylation carcinogenesis, inhibited; cell growth, inhibited; transcription, inhibited; signaling pathway regulation CTNNB1(DISRUPTS); BTRC(INDUCES) 22494971; 30413483 2 1 0 ERK phosphorylation, ERK pathway activation +Myod1 MyoD DNA-binding; RNA splicing; Transcription factor P10085 17927 7 B3|7 30.03 cM mouse K102-ac 458969 LWACKACkRKTTNAD Basic activity, induced transcription, induced 10944526 3 1 1 +UHRF1 UHRF1 DNA-binding; EC 6.3.2.-; EC 6.3.2.19; Ligase; Transcription factor; UBIQUITIN LIGASE; Ubiquitin conjugating system; Ubiquitin ligase Q96T88 29128 19p13.3 human K646-ac 1883407604 SPRTGKGkWKRKSAG cell cycle regulation; cell growth, induced 35951156 1 0 0 +TFB2M TFB2M EC 2.1.1.-; METHYLTRANSFERASE; Methyltransferase; Transcription, coactivator/corepressor Q9H5Q4 64216 1q44 human T313-p 55379187 NLFTKNLtPMNYNIF RrnaAD molecular association, regulation; protein conformation transcription, inhibited POLRMT(DISRUPTS) DNA(DISRUPTS) 32505352 1 1 0 +PPP2R5C PPP2R5C Motility/polarity/chemotaxis; PHOSPHATASE; Protein phosphatase, regulatory subunit Q13362 5527 14q32.31 human S520-p 18958501 CRADELAsQDGR___ protein stabilization; molecular association, regulation; ubiquitination; phosphorylation cell cycle regulation; carcinogenesis, inhibited; cell growth, inhibited; transcription, induced MDM2(DISRUPTS); p53(INDUCES) 21460856 1 0 12 induces dephosphorylation of p53 +LTB4R LTB4R GPCR, family 1; Membrane protein, integral; Membrane protein, multi-pass; Receptor, GPCR Q15722 1241 14q12 human S314-p 25299233 GTGSEASsTRRGGSL receptor internalization, induced; phosphorylation signaling pathway regulation 22707565; 30131369 2 2 1 phosphorylation of LTB4R basal phosphorylation site; enhanced ligand-induced internalization ; chemotaxis, B-hexisaminidase release, regulates LTB4R function +CD300LF IREM-1 Immunoglobulin superfamily; Membrane protein, integral; Receptor, misc. Q8TDQ1 146722 17q25.1 human Y205-p 474545 PLEGDLCyADLTLQL SIT activity, induced; molecular association, regulation; enzymatic activity, induced SHP-1(INDUCES) 15549731; 17202342; 32152116 4 0 0 activation of PLC gamma which leads to the activation of PKC; mutation of site to Phe decreased the inhibitory activity of IREM-1 +DMTN dematin Actin-binding; Motility/polarity/chemotaxis; Tumor suppressor Q08495 2039 8p21.3 human S92-p 456372 SLSPKSTsPPPSPEV AbLIM_anchor protein conformation 19030997 1 23 1 facilitating actin bundling activity +Sp7 osterix C2H2-type zinc finger protein; DNA-binding; Transcription factor Q8VI67 170574 15|15 F3 mouse S73-p 15334100 SSTNGLLsPAGSPPA activity, induced; protein degradation; molecular association, regulation; ubiquitination cell differentiation, inhibited; transcription, altered FBXW7(INDUCES); p300(INDUCES); SMARCA4(INDUCES) 20682789; 32931083 4 0 0 +Ptpn5 STEP EC 3.1.3.48; Membrane protein, multi-pass; Motility/polarity/chemotaxis; PHOSPHATASE; Protein phosphatase, tyrosine (non-receptor) P54830 19259 7 B3|7 30.7 cM mouse S221-p 448294 GLQERRGsNVSLTLD molecular association, regulation; enzymatic activity, inhibited; phosphorylation ERK1(DISRUPTS); ERK2(DISRUPTS) 25583483; 25689923 9 0 0 +SIK2 QIK EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, CAMK; Protein kinase, Ser/Thr (non-receptor) Q9H0K1 23235 11q23.1 human T484-p 478056 RSGQRRHtLSEVTNQ protein stabilization 30586628 3 10 85 +Tnfrsf1a TNF-R1 Membrane protein, integral; Receptor, cytokine P25118 21937 6 F3|6 59.32 cM mouse K256-ub 52440800 CRDPVPVkEEKAGKP ubiquitination 26649818 1 1 0 +NFE2L2 NRF2 DNA-binding; Transcription factor Q16236 4780 2q31.2 human K462-ac 7106318 TRDELRAkALHIPFP molecular association, regulation transcription, induced DNA(INDUCES) 19273602 1 1 0 +PPP2CA PPP2CA EC 3.1.3.16; Motility/polarity/chemotaxis; PHOSPHATASE; Protein phosphatase, Ser/Thr (non-receptor) P67775 5515 5q31.1 human Y284-p 457325 ELDDTLKySFLQFDP protein conformation; phosphorylation 35820485 1 2 17 +Stk38 NDR1 EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, AGC; Protein kinase, Ser/Thr (non-receptor) Q91VJ4 106504 17|17 A3.3 mouse T444-p 460659 DWVFINYtYKRFEGL Pkinase_C enzymatic activity, induced apoptosis, induced; signaling pathway regulation 21730291 7 2 1 MST-NDR pathway +ITGB4 ITGB4 iso2 Cell adhesion; Membrane protein, integral; Motility/polarity/chemotaxis; Receptor, misc. P16144-2 3691 17q25.1 human T1736-p 1243302 EFVSRTLtTSGTLST molecular association, regulation; intracellular localization; protein conformation Plectin-1(DISRUPTS); ITGB4 iso2(INDUCES) 22357621 2 1 4 regulates HD assembly +ETV1 ETV1 DNA-binding; Oncoprotein; Transcription factor P50549 2115 7p21.2 human K116-ac 458951 FKFSYGEkCLYNVSA ETS_PEA3_N protein stabilization; molecular association, regulation transcription, induced DNA(INDUCES) 12917345 1 1 0 +CREB1 CREB DNA-binding; Transcription factor P16220 1385 2q33.3 human S115-p 450092 QKRREILsRRPSYRK pKID molecular association, regulation cell growth, induced; transcription, induced MEIS1(INDUCES) 20541704 10 0 2 +Kcnd2 Kv4.2 Channel, potassium; Membrane protein, integral; Membrane protein, multi-pass Q9Z0V2 16508 6 A2-A3.1|6 8.49 cM mouse T607-p 457612 IPTPPVTtPEGDDRP activity, induced neural plasticity 16251476; 32824677 7 0 0 the T607D mutant effects required KChIP3 coexpression. Mutation with 3 residues mutated to D decreased the transient outward K+ current and showed higher activation voltage. ; regulates neuronal excitability and behavioral seizure strength +H2BC3 H2B DNA-binding P33778 3018 6p22.2 human K125-ub 12093729 VTKYTSSk_______ molecular association, regulation; intracellular localization DNA repair, induced 21362549 2 2 1 RNF20-RNF40 is required for retention of XRCC4 at DSB sites +MECP2 MECP2 Transcription, coactivator/corepressor P51608 4204 Xq28 human S229-p 1727702 VKMPFQTsPGGKAEG molecular association, regulation transcription, induced; transcription, altered YB-1(INDUCES); SIN3A(INDUCES); HP1 alpha(INDUCES); SMC3(INDUCES) 22615490 3 28 0 Induces RET expression; Phosphorylation of S80 and S229 leads to activation and repression of EGR2 expression. Phosphorylated S80 interacts with YB-1 in RNA dependent manner +AKAP12 AKAP12 Adaptor/scaffold Q02952 9590 6q25.1 human S732-p 481957 TDGILAGsQEHDPGQ molecular association, regulation; intracellular localization DNA repair, induced DNA(INDUCES) 27683220 1 4 0 +Pdcl PhLP G protein regulator, misc. Q63737 64013 3q11 rat S18-p 448823 EKLQYYYsTSEDEDS activity, inhibited 12466282 4 4 2 +HTT Huntingtin Cytoskeletal P42858 3064 4p16.3 human K6-ub 1877148902 __MATLEkLMKAFES ubiquitination 32675242 1 0 0 K6 and K9 sites were ubquitinated in WT were mutated to R and slowed aggregation and reduce size, but increase in smaller size aggregates but increased death rates. +Ripk2 RIPK2 EC 2.7.10.2; EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, Ser/Thr (non-receptor); Protein kinase, TKL; Protein kinase, tyrosine (non-receptor) P58801 192656 4 A2|4 6.7 cM mouse K209-ub 2793000 QKSRASVkHDIYSYA PK_Tyr_Ser-Thr phosphorylation; enzymatic activity, induced signaling pathway regulation 23109427 3 1 0 regulation NOD2 signaling +Snai2 Snail2 Apoptosis; C2H2-type zinc finger protein; Motility/polarity/chemotaxis; Transcription factor P97469 20583 16 A1|16 10.07 cM mouse S4-p 25525401 ____MPRsFLVKKHF transcription, inhibited 22567133 1 0 0 regulates epithelial to mesenchymal transition (EMT) +Slc12a3 NCCT Membrane protein, integral; Membrane protein, multi-pass; Transporter; Transporter, SLC family P59158 20497 8 C5|8 46.46 cM mouse T48-p 4709842 SHLTHGStLYMRTFG AA_permease_N activity, induced; phosphorylation 22342722 4 1 0 increases NCCT protein abundance and its phosphorylation by activated OSR1 +ACLY ACLY Carbohydrate Metabolism - citrate (TCA) cycle; EC 2.3.3.8; Lyase; Transferase P53396 47 17q21.2 human T447-p 455371 NASGSTStPAPSRTA signaling pathway regulation 26039450 2 3 62 IGF1/AKT/ACL/cardiolipin/ATP pathway +PAK3 PAK3 EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, STE; Protein kinase, Ser/Thr (non-receptor) O75914 5063 Xq23 human T436-p 448126 PEQSKRStMVGTPYW Pkinase cytoskeletal reorganization 17077177 3 2 11 Mutation of any of the 4 serines/threonines to alanine reduced the AILIM/ICOS-induced elongation ratio in activated T cells. Three sites are believed to be autophosphorylation sites, and one is believed to be an Akt1 site. Treatment with Akt inhibitor shows a reduction in this elongation ratio. +Arhgap42 ARHGAP42 GAP; GAP, Rac/Rho B2RQE8 71544 9|9 A1 mouse Y342-p 450878 MDGKEPIyTLPAIIS cell cycle regulation; cell motility, altered 18515860 1 19 227 +TCEAL1 SIIR iso2 Transcription initiation complex AAA60149 9338 Xq22.2 human S37-p 451218 KSSPPRSsLRRSSPR BEX transcription, altered 7592688 1 0 0 S36A/S37A mutation resulted in a substantial loss of LTR repression function suggesting that RSV LTR repression may be regulated by S36 and/or S37 phosphorylation. +Mapt Tau ACETYLTRANSFERASE; Acetyltransferase; Cytoskeletal P19332 29477 10q32.1 rat S546-p 449080 VVRTPPKsPSASKSR cytoskeletal reorganization 18245083 45 36 25 +Igf1r IGF1R EC 2.7.10.1; KINASE; Kinase, protein; Membrane protein, integral; Protein kinase, TK; Protein kinase, tyrosine (receptor) Q60751 16001 7 C|7 37.27 cM mouse Y1167-p 448387 RDIYETDyYRKGGKG PK_Tyr_Ser-Thr intracellular localization; enzymatic activity, induced cell cycle regulation; cell growth, induced; cell differentiation, induced; cell motility, altered 18515860; 23954591; 35320720; 8940173 20 38 707 +FOXP3 FOXP3 C2H2-type zinc finger protein; Cell cycle regulation; DNA-binding; Transcription factor Q9BZS1 50943 Xp11.23 human K268-ac 25614401 AGKMALTkASSVASS protein stabilization 23644046 3 1 0 +TFCP2L1 TFCP2L1 DNA-binding Q9NZI6 29842 2q14.2 human K30-sm 25352008 VLALPIFkQEEPQLS CP2 transcription, inhibited 20661472 1 1 0 +IL9R IL9R Membrane protein, integral; Receptor, cytokine Q01113 3581 Xq28 and Yq12 human S518-p 450656 SVLSKARsWTF____ molecular association, regulation 14-3-3 zeta(INDUCES) 10642536 1 0 0 +Pdcl PhLP G protein regulator, misc. Q63737 64013 3q11 rat T19-p 448824 KLQYYYStSEDEDSD activity, inhibited 12466282 4 3 3 +IKBKG IKKG Adaptor/scaffold; Protein kinase, regulatory subunit Q9Y6K9 8517 Xq28 human K321-ub 7482000 AERQAREkLAEKKEL CC2-LZ signaling pathway regulation 17728323 2 1 0 +PSMC4 RPT3 Nuclear receptor co-regulator; Protease; Proteasome complex P43686 5704 19q13.2 human T25-p 3190483 LSVSRPQtGLSFLGP activity, induced; enzymatic activity, induced cell cycle regulation; carcinogenesis, induced; carcinogenesis, inhibited; cell growth, induced 26655835; 31754034 3 4 7 regulates proteasome function; peptidase activity of 26S proteosome inhibited; required for efficient proteasomal degradation +PTEN PTEN Carbohydrate Metabolism - inositol phosphate; EC 3.1.3.16; EC 3.1.3.48; EC 3.1.3.67; Motility/polarity/chemotaxis; Nuclear receptor co-regulator; PHOSPHATASE; Phosphatase, lipid; Tumor suppressor P60484 5728 10q23.31 human K266-sm 27490409 HKQNKMLkKDKMFHF PTEN_C2 protein stabilization; molecular association, regulation; ubiquitination; intracellular localization cell cycle regulation; carcinogenesis, inhibited; apoptosis, induced; cell growth, inhibited ubiquitin(DISRUPTS) 23013792; 24344134; 27506944; 27852060 4 0 0 +Sh2b1 SH2-B-beta Adaptor/scaffold Q62985 89817 1q36 rat Y439-p 448753 DRLSQGAyGGLSDRP cell motility, induced; cytoskeletal reorganization 12551917; 23444381 2 1 1 membrane ruffling; macrophage migration +FOXO3 FOXO3A Autophagy; DNA-binding; Oncoprotein; Transcription factor O43524 2309 6q21 human S399-p 20799902 DNITLPPsQPSPTGG phosphorylation transcription, induced 17711846 2 1 0 induces phosphorylation of other sites +AVPR2 AVPR2 GPCR, family 1; Membrane protein, integral; Membrane protein, multi-pass; Receptor, GPCR; Transporter; Transporter, aquaporin family P30518 554 Xq28 human S364-p 451069 SCTTASSsLAKDTSS intracellular localization 9482866 1 0 0 After receptor activation, phosphorylation of serines 362, 363, and 364 inhibits overall dephosphorylation of the internalized receptor, thereby inhibiting recycling of the receptor to the cell surface. +DPYSL2 CRMP-2 Microtubule-binding; Motility/polarity/chemotaxis Q16555 1808 8p21.2 human T509-p 448083 PVCEVSVtPKTVTPA molecular association, regulation; intracellular localization apoptosis, induced DRP1(DISRUPTS); RHOT2(DISRUPTS); MFN2(DISRUPTS) 34831395; 37174687 16 63 34 +Rps6ka1 p90RSK EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, AGC; Protein kinase, Ser/Thr (non-receptor); Translation P18653 20111 4|4 D2.3 mouse T348-p 447992 DTEFTSRtPRDSPGI Pkinase_C enzymatic activity, induced 14726002 41 28 2 +RPS10 RPS10 Nucleolus; RNA-binding; Ribosomal; Translation P46783 6204 6p21.31 human R158-me 13906404 QFRGGFGrGRGQPPQ protein stabilization; molecular association, regulation; intracellular localization NPM1(INDUCES) 20159986 1 0 0 localization in the granular component (GC) region of the nucleolus; efficient assembly of RPS10 into ribosomes and protein synthesis +VIM Vimentin Cytoskeletal; Motility/polarity/chemotaxis P08670 7431 10p13 human S72-p 449026 SSAVRLRsSVPGVRL Filament_head activity, induced carcinogenesis, induced; cell motility, induced; cytoskeletal reorganization; cell motility, inhibited 23737341; 25908861; 28117759; 31931758 21 34 40 +Pdha1 PDHA1 Amino Acid Metabolism - valine, leucine and isoleucine biosynthesis; Carbohydrate Metabolism - butanoate; Carbohydrate Metabolism - citrate (TCA) cycle; Carbohydrate Metabolism - glycolysis and gluconeogenesis; Carbohydrate Metabolism - pyruvate; EC 1.2.4.1; Mitochondrial; Oxidoreductase P35486 18597 X F4|X 73.95 cM mouse S300-p 448259 SMSDPGVsYRTREEI E1_dh enzymatic activity, inhibited 31435015; 32079675; 33826891; 36211560 53 76 476 +TOP2A TOP2A EC 5.99.1.3; Isomerase P11388 7153 17q21.2 human K1240-sm 15511902 KKNKKKIkNENTEGS intracellular localization 30871006 1 5 0 influences mitotic localization of TOP2A +Myc Myc DNA-binding; Nucleolus; Oncoprotein; Transcription factor P01108 17869 15 D1|15 26.19 cM mouse S77-p 448586 LLPTPPLsPSRRSGL Myc_N protein degradation; protein stabilization; molecular association, regulation; phosphorylation cell cycle regulation; carcinogenesis, induced; carcinogenesis, inhibited; cell growth, inhibited; signaling pathway regulation; transcription, altered; cell growth, induced; apoptosis, inhibited PIN1(INDUCES) 15048125; 34088288; 35380701; 36581205; 36765089 86 38 33 +VCPIP1 VCIP135 Cell cycle regulation; DEUBIQUITINASE; EC 3.4.19.12; Protease; Ubiquitin conjugating system; Ubiquitin-specific protease Q96JH7 80124 8q13.1 human S768-p 3149749 TPTKAPYsPTTSKEK molecular association, regulation cell cycle regulation VCP(DISRUPTS) 23500464 1 20 7 Golgi disassembly at mitosis, inhibits membrane fusion +H3C1 H3 DNA-binding P68431 8350 6p22.2 human R8-m2 4279300 ARTKQTArKSTGGKA Histone molecular association, regulation; enzymatic activity, inhibited 19187761 6 1 0 MLL1 reduced methyltransferase activity and binding affinity with substrate with R8-M2 modification as compared to substrate with no modification +SUGT1 SUGT1 Cell cycle regulation; Ubiquitin conjugating system Q9Y2Z0 10910 13q14.3 human S17-p 140698200 TSQRFFQsFSDALID protein stabilization; molecular association, regulation cell cycle regulation RNF41(INDUCES) 28696259 1 1 0 +Eif3f eIF3-epsilon EC 3.4.19.12; Translation; Translation initiation Q9DCH4 66085 7|7 E3 mouse K242-ub 7388003 MFTPLTVkYAYYDTE protein degradation 19073596 1 4 9 regulates skeletal muscle atrophy +TBXA2R TXA2-R GPCR, family 1; Membrane protein, integral; Membrane protein, multi-pass; Receptor, GPCR P21731 6915 19p13.3 human S329-p 450989 RLSTRPRsLSLQPQL receptor desensitization, altered 10827090 3 8 2 TXA2-R alpha is subject to cross-desensitization by the prostacyclin receptor which is mediated through direct PKA phosphorylation of S329. +Lats1 LATS1 EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, AGC; Protein kinase, Ser/Thr (non-receptor); Tumor suppressor Q8BYR2 16798 10|10 A1 mouse T1078-p 457595 EHAFYEFtFRRFFDD carcinogenesis, inhibited; cell growth, inhibited; apoptosis, induced; cell motility, inhibited; transcription, inhibited 35697803 34 1 0 +ATRIP ATRIP Cell cycle regulation; DNA repair, damage; DNA-binding Q8WXE1 84126 3p21.31 human S239-p 485777 VIKPEACsPQFGKTS cell cycle regulation BRCA1(INDUCES) 17616665 1 15 13 required for checkpoint function +Notch1 Notch 1 Membrane protein, integral; Motility/polarity/chemotaxis; Oncoprotein; Receptor, misc.; Transcription factor Q01705 18128 2 A3|2 18.91 cM mouse R2253-m2 56852000 AALAGGSrLAFEPPP activity, induced; protein degradation; ubiquitination transcription, induced 25805888 1 1 0 +ZMYM2 ZNF198 Transcription factor Q9UBW7 7750 13q12.11 human K963-sm 12004417 MMSEDEGkTETTNIN molecular association, regulation; intracellular localization PML(INDUCES) 17027752 1 0 0 PLM body formation +STAT3 STAT3 DNA-binding; Motility/polarity/chemotaxis; Nuclear receptor co-regulator; Transcription factor P40763 6774 17q21.2 human Y705-p 448192 DPGSAAPyLKTKFIC activity, induced; protein degradation; molecular association, regulation; methylation; intracellular localization; enzymatic activity, induced; phosphorylation cell cycle regulation; carcinogenesis, induced; apoptosis, induced; cell motility, induced; signaling pathway regulation; cell differentiation, altered; cell growth, induced; cell motility, altered; transcription, inhibited; cell growth, altered; carcinogenesis, altered; carcinogenesis, inhibited; cell growth, inhibited; transcription, induced; transcription, altered; endocytosis, induced; chromatin organization, altered; cell differentiation, induced; apoptosis, inhibited; cytoskeletal reorganization; cell adhesion, altered; autophagy, inhibited NPM1(INDUCES); PLCG1(INDUCES); PIAS3(INDUCES); HP1 alpha(DISRUPTS); DDX5(INDUCES); PKCD(INDUCES); STAT3(INDUCES); STAT1(INDUCES); ER-alpha(INDUCES) DNA(INDUCES) 10845908; 11350938; 11470914; 11536047; 12384432; 12637586; 12684046; 14551213; 15007380; 15077188; 15151905; 15155836; 15465816; 15950906; 16651438; 16951338; 17202361; 17276988; 17360477; 17543278; 17726024; 18198175; 18430728; 18498667; 18519681; 18550668; 18939995; 19147545; 20388777; 20595392; 21057531; 21398617; 21478911; 21586612; 21840932; 22306293; 24793791; 25417160; 25961936; 26028030; 26787900; 27748760; 27941883; 30054295; 30741923; 31170499; 31409371; 31900385; 31956373; 31976162; 32015548; 32029900; 32087696; 32094172; 32164483; 33512408; 33513694; 33687738; 33689932; 33706413; 33774038; 33774344; 33820781; 33824475; 33846242; 33909625; 33947048; 33963314; 33986510; 34015398; 34021045; 34031055; 34066153; 34067421; 34118143; 34244887; 34247191; 34380633; 34411141; 34433042; 34469737; 34480897; 34502195; 34525179; 34531850; 34675408; 34703823; 34744770; 34764490; 34874746; 34900727; 35031324; 35091679; 35184394; 35245627; 35296317; 35367211; 35476936; 35670018; 35712699; 35820864; 35932642; 35995859; 36017196; 36053753; 36066408; 36068200; 36103247; 36362294; 36374556; 36443287; 36509141; 36512575; 36516775; 36630607; 36806887; 36807142; 36922677; 37020037; 37097001; 37126127; 37511611; 8626374 541 75 3065 +Tbc1d1 TBC1D1 DEUBIQUITINASE; GAP; GAP, Rab; Ubiquitin-specific protease Q60949 57915 5 C3.1|5 32.8 cM mouse S660-p 2228809 PRLNPSAsSPNFFKY molecular association, regulation carcinogenesis, induced; cell motility, induced; cell growth, induced; transcription, induced; signaling pathway regulation FZD7(INDUCES) 36371204 3 8 0 induces the WNT pathway +TNFRSF10A TRAIL-R1 Membrane protein, integral O00220 8797 8p21.3 human K273-ub 27581521 SGCGGDPkCMDRVCF receptor internalization, induced; protein degradation; molecular association, regulation carcinogenesis, inhibited; apoptosis, induced; apoptosis, inhibited MARCH1(INDUCES); MARCH8(INDUCES) 23300075; 28671676 2 0 0 proapoptotic effect of TRAIL (chemotherapy) +Ddx41 DDX41 EC 3.6.4.13; Helicase; RNA splicing; RNA-binding; Spliceosome Q91VN6 72935 13|13 B1 mouse K115-ub 27992510 KQLKEEEkILESVAE protein degradation transcription, inhibited 23222971 1 1 0 +CD274 PD-L1 Membrane protein, integral Q9NZQ7 29126 9p24.1 human S279-p 1872811800 CGIQDTNsKKQSDTH protein degradation; molecular association, regulation; ubiquitination carcinogenesis, inhibited ARIH1(INDUCES) 33879767 1 1 0 +NR1I2 PXR DNA-binding; Nuclear receptor O75469 8856 3q13.33 human T57-p 6370304 GYHFNVMtCEGCKGF zf-C4 molecular association, regulation; intracellular localization; activity, inhibited transcription, altered; transcription, inhibited DNA(NOT_REPORTED); DNA(DISRUPTS) 19171678; 19617467 3 0 0 inhibits transcription; PXR T57D (but not T57A) mutant fails to bind to the CYP3A4 promoter +Gsc GSC DNA-binding; Transcription factor Q02591 14836 12 E|12 54.32 cM mouse K183-sm 2887204 ENLFQETkYPDVGTR Homeodomain transcription, inhibited 18336814 1 0 0 SUMO modification inhibition is promoter specific +TRIM63 MURF1 EC 6.3.2.-; EC 6.3.2.19; Ligase; UBIQUITIN LIGASE; Ubiquitin conjugating system; Ubiquitin ligase Q969Q1 84676 1p36.11 human K238-sm 1877577300 ITQEQEKkLSFIEAL intracellular localization 29868881 1 1 0 translocation to nucleus +AATF AATF Nucleolus; RNA-binding; Transcription factor Q9NY61 26574 17q12 human S189-p 3753300 EGDDAEDsQGESEED protein stabilization; molecular association, regulation apoptosis, inhibited; transcription, altered NFkB-p65(INDUCES) DNA(INDUCES) 17157788 1 0 4 +Parp2 PARP2 DNA repair, damage; EC 2.4.2.30; Transferase O88554 11546 14 26.25 cM|14 C1 mouse K37-ac 2459113 DDSPPGKkMRTCQRK molecular association, regulation; intracellular localization; enzymatic activity, inhibited DNA(DISRUPTS) 18436469 1 0 0 +AR AR DNA-binding; Nuclear receptor; Transcription factor P10275 367 Xq12 human K388-sm 2793917 PHPHARIkLENPLDY Androgen_recep protein degradation; molecular association, regulation; ubiquitination; intracellular localization; activity, inhibited carcinogenesis, induced; transcription, induced; transcription, inhibited RAI17(INDUCES) DNA(INDUCES) 11121022; 12177000; 14609956; 15031320; 31620784; 31752909; 32948192 8 1 0 chromatin enrichment independent of ligand activation +Mpl MPL Membrane protein, integral; Receptor, cytokine Q08351 17480 4 D2.1|4 54.61 cM mouse S541-p 3091400 LRDTAALsPSKATVT activity, induced; phosphorylation cell growth, altered 10918061 1 0 0 tyrosine phosphorylation of JAK2 +CREB3 CREB3 Membrane protein, integral; Transcription factor O43889 10488 9p13.3 human S46-p 1827354100 LPLSEVPsDWEVDDL protein degradation 31941600 1 0 0 reduced CREB3 stability +Dab1 DAB1 Adaptor/scaffold P97318 13131 4 C6|4 47.79 cM mouse Y185-p 447959 KQCEQAVyQTILEED molecular association, regulation; intracellular localization neural plasticity; cell differentiation, induced; cell motility, altered; cytoskeletal reorganization Src(INDUCES); SOCS1(INDUCES); PIK3R1(INDUCES) 14517291; 19796633; 22586277 6 0 0 alternatively spliced variants +TJP2 ZO2 Adaptor/scaffold; Motility/polarity/chemotaxis Q9UDY2 9414 9q21.11 human K992-ub 1883981503 NSPPPAFkPEPPKAK protein stabilization; molecular association, regulation occludin(INDUCES); ZO1(INDUCES) 36291162 1 0 0 stability of hZO-2 is regulated by K48 polyubiquitin and K759, K997 ubiquitylation and K730 SUMOylation, mutations in ZO2 ubiquitylation and ylation sites disrupt the interaction with occludin and ZO1as well as tight junction (TJ) barrier function +PKP1 plakophilin 1 Cell adhesion; Motility/polarity/chemotaxis Q13835 5317 1q32.1 human T171-p 27717301 RGTLRKGtLGSKGQK activity, induced; protein stabilization cell motility, induced; cell growth, induced; translation, induced; cell adhesion, inhibited 23444369 1 2 0 +PFKFB3 PFKFB3 Carbohydrate Metabolism - fructose and mannose; EC 2.7.1.105; EC 3.1.3.46; KINASE; Kinase, other; Motility/polarity/chemotaxis; PHOSPHATASE; Phosphatase (non-protein) Q16875 5209 10p15.1 human S461-p 448801 NPLMRRNsVTPLASP molecular association, regulation; intracellular localization; phosphorylation; enzymatic activity, induced carcinogenesis, induced; cell motility, induced; cell growth, induced; apoptosis, inhibited; transcription, induced; signaling pathway regulation KPNA1(INDUCES); HIF1A(INDUCES) 16115917; 23548149; 35072776; 35707221; 35804016 10 47 83 regulates the YAP/TAZ pathway +SRC Src EC 2.7.10.2; KINASE; Kinase, protein; Oncoprotein; Protein kinase, TK; Protein kinase, tyrosine (non-receptor) P12931 6714 20q11.23 human Y522-p 7445100 LQAFLEDyFTSTEPQ enzymatic activity, inhibited 22238675 8 0 0 +RUNX1 AML1 DNA-binding; Oncoprotein; Transcription factor Q01196 861 21q22.12 human K90-ub 95155312 KTLPIAFkVVALGDV Runt protein degradation; intracellular localization carcinogenesis, inhibited; cell growth, inhibited; transcription, inhibited 28536267 1 0 0 +Amfr AMFR EC 6.3.2.-; EC 6.3.2.19; Endoplasmic reticulum; Ligase; Membrane protein, integral; Membrane protein, multi-pass; Motility/polarity/chemotaxis; Receptor, misc.; UBIQUITIN LIGASE; Ubiquitin conjugating system; Ubiquitin ligase Q9R049 23802 8 C5|8 45.96 cM mouse S542-p 469879 ERVPLDLsPRLEETL molecular association, regulation 26337390 1 32 0 S538 phosphorylation limited its ability to induce mitochondrial fusion, regulates ER-mitochondria association and thereby mitofusin degradation and mitochondrial motility +Nrip1 RIP140 Nuclear receptor co-regulator; Transcription, coactivator/corepressor Q8CBD1 268903 16|16 C3.1 mouse K111-ac 459034 SIVNLNVkKEALLAG NRIP1_repr_1 intracellular localization transcription, inhibited 15879431 1 2 0 +EP300 p300 ACETYLTRANSFERASE; Acetyltransferase; EC 2.3.1.48; Motility/polarity/chemotaxis; Nuclear receptor co-regulator; Transcription, coactivator/corepressor Q09472 2033 22q13.2 human R2142-me 2584301 PMQAGVQrAGLPQQQ molecular association, regulation transcription, induced GRIP1(DISRUPTS) 15731352 1 0 0 +RASSF1 RASSF1 iso2 Tumor suppressor Q9NS23-2 11186 3p21.31 human S184-p 7447198 PSSKKPPsLQDARRG molecular association, regulation; intracellular localization cell cycle regulation 24197116 1 2 0 Phosphorylated RASSF1 regulates association with microtubules and ability to induce mitotic arrest. +Pde4d PDE4D iso6 EC 3.1.4.53; Nucleotide Metabolism - purine; Phosphodiesterase P14270-6 24627 rat S67-p 483644 SFLYRSDsDYDLSPK cell cycle regulation 24815749 3 24 3 +Myf6 Myf-6 DNA-binding; Transcription factor P15375 17878 10 D1|10 55.96 cM mouse S42-p 2907503 PGSDGTLsPCQDQMP Basic cell differentiation, altered; transcription, inhibited 14739931 1 0 0 +Glo1 GLO1 Carbohydrate Metabolism - pyruvate; EC 4.4.1.5; Lyase Q9CPU0 109801 17 A3.3|17 15.69 cM mouse T107-p 7106304 ELTHNWGtEDDETQS Glyoxalase protein stabilization; ubiquitination; enzymatic activity, induced 32966793 3 0 0 inhibits ubiquitination +RCC1 RCC1 Cell cycle regulation; GEF; GEF, Ras P18754 1104 1p35.3 human S26-p 2850002 KSKKVKVsHRSHSTE molecular association, regulation KPNA4(DISRUPTS) 18568422 1 0 0 +CNKSR1 CNK1 Adaptor/scaffold; G protein regulator, misc. Q969H4 10256 1p36.11 human Y665-p 33638001 KEQNRELySEGLGAW activity, induced; molecular association, regulation; phosphorylation cell growth, induced; transcription, inhibited; signaling pathway regulation EFNB1(INDUCES); RAF1(INDUCES) 24825906; 26319181 2 1 0 +BRCA2 BRCA2 DNA repair, damage; Nuclear receptor co-regulator; Tumor suppressor P51587 675 13q13.1 human S3291-p 455462 SPICTFVsPAAQKAF molecular association, regulation cell cycle regulation; chromatin organization, altered; DNA repair, inhibited RAD51(DISRUPTS) 15800615; 17515903; 18593900; 32726637 8 1 0 +Aurkc AurC EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, Other; Protein kinase, Ser/Thr (non-receptor) O88445 20871 7 A1|7 4.06 cM mouse T171-p 455456 TPSLRRKtMCGTLDY Pkinase enzymatic activity, inhibited; enzymatic activity, induced cell cycle regulation 11879579; 20484572; 24586209 7 11 83 oocyte meiosis +DVL3 DVL3 Motility/polarity/chemotaxis Q92997 1857 3q27.1 human S643-p 34668102 SHHSLASsLRSHHTH Dsh_C intracellular localization 24993822; 27486244 2 2 0 centrosomal signal for pS697 accumulated throughout the cell cycle, pS280 only in mitotic spindle and not in the interphase centrosome +Daxx DAXX Apoptosis; Nuclear receptor co-regulator; Nucleolus; Transcription, coactivator/corepressor O35613 13163 17 B1|17 17.98 cM mouse S669-p 7249306 TSVQPMPsPPLASVA activity, induced 12529400 1 2 0 Phosphorylation of S669 may downregulate Daxx-mediated transcriptional repression. +MDM2 MDM2 EC 6.3.2.-; EC 6.3.2.19; Inhibitor; Ligase; NEDDYLATION LIGASE; Neddylation Ligase; Nucleolus; Oncoprotein; UBIQUITIN LIGASE; Ubiquitin conjugating system; Ubiquitin ligase Q00987 4193 12q15 human S188-p 453413 RKRHKSDsISLSFDE molecular association, regulation; protein stabilization; ubiquitination signaling pathway regulation ER-beta(INDUCES); CBP(INDUCES) 15169778; 22349818 3 1 1 +CD44 CD44 iso12 Cell adhesion; Membrane protein, integral; Motility/polarity/chemotaxis; Receptor, misc. P16070-12 960 11p13 human S325-p 450988 LNGEASKsQEMVHLV cell adhesion, inhibited 25809479 12 58 37 monocyte-adhesive hyaluronan coats on keratinocytes +Ikbkb IKKB EC 2.7.11.10; KINASE; Kinase, protein; Protein kinase, Other; Protein kinase, Ser/Thr (non-receptor) O88351 16150 8|8 A2 mouse S689-p 3676802 SHPGQLMsQPSSACD molecular association, regulation; phosphorylation PPP2R3C(INDUCES) 20925653 1 1 0 interaction with PPP2R3C (aka G4-1) downregulates IKK-beta activity; S181 phosphorylation increased in S679/682/689/692/697/701/705A mutant +TMOD1 TMOD1 Cell development/differentiation; Contractile; Cytoskeletal; Motility/polarity/chemotaxis P28289 7111 9q22.33 human T54-p 22561900 GLRQKDQtTKAPTGP Tropomodulin cytoskeletal reorganization 19137675 2 0 0 involved in TMOD1 function in actin capping +SF3B1 SF3B1 RNA splicing; RNA-binding; Spliceosome O75533 23451 2q33.1 human T313-p 449360 HGSGWAEtPRTDRGG molecular association, regulation NIPP-1(INDUCES) 12105215 2 32 99 +NDE1 NUDE1 iso1 Cell cycle regulation; Cytoskeletal; Microtubule-binding Q9NXR1-1 54820 16p13.11 human T228-p 449452 GPSSSLNtPGSFRRG NUDE_C molecular association, regulation; intracellular localization ZNF365(DISRUPTS) 16682949 2 10 18 +Ripk1 RIPK1 EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, Ser/Thr (non-receptor); Protein kinase, TKL Q60855 19766 13 A3.3|13 14.01 cM mouse K376-ub 486338 NDRSVQAkLQEEASY ubiquitination; enzymatic activity, inhibited apoptosis, inhibited 31519886; 31519887 11 0 0 promotes NF-?B activation ; NF-?B activation upon TNF treatment, K376-mediated RIPK1 ubiquitination is critical for restraining cell death and inflammation during postnatal development +Scnn1g ENaC-gamma Channel, sodium; Membrane protein, integral; Membrane protein, multi-pass; Transporter, ion channel P37091 24768 1q36 rat T623-p 451220 PGSTVPGtPPPRYNT molecular association, regulation; activity, inhibited NEDD4L(DISRUPTS) 11805112; 16476738 4 0 0 +VIPR1 VIPR1 GPCR, family 2; Membrane protein, integral; Membrane protein, multi-pass; Motility/polarity/chemotaxis; Receptor, GPCR P32241 7433 3p22.1 human S447-p 455662 VSPGARRsSSFQAEV receptor desensitization, altered 14645688 1 2 0 +LRRK2 LRRK2 EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, Ser/Thr (non-receptor); Protein kinase, TKL Q5S007 120892 12q12 human S1444-p 15785707 NIKARASsSPVILVG Roc molecular association, regulation; enzymatic activity, induced 14-3-3 beta(INDUCES); 14-3-3 sigma(INDUCES); 14-3-3 theta(INDUCES); 14-3-3 zeta(INDUCES); 14-3-3 epsilon(INDUCES); 14-3-3 gamma(INDUCES); 14-3-3 eta(INDUCES) 24351927; 32317922 3 2 0 +FOXO1 FOXO1A DNA-binding; Nuclear receptor co-regulator; Oncoprotein; Transcription factor Q12778 2308 13q14.11 human S329-p 448076 STISGRLsPIMTEQD intracellular localization transcription, altered; transcription, inhibited 11311120; 14664696; 20061393; 30971493 11 13 19 +Cry2 CRY2 DNA-binding; Lyase Q9R194 12953 2|2 E1 mouse S557-p 456803 ALSSGPAsPKRKLEA protein degradation; intracellular localization; phosphorylation transcription, induced 15980066; 20123978; 25288642 4 14 1 stimulates phosphorylation of S553; S557 is required for normal expression of a subset of the clock genes; cellular distribution of PER2; required for the circadian time-keeping mechanism +NFKB1 NFkB-p105 DNA-binding; Transcription factor P19838 4790 4q24 human S907-p 451565 QAHSLPLsPASTRQQ activity, induced; protein stabilization; protein processing 12871932; 8522173 2 23 128 Mutation of this site retards the proteolytic processing of p105 that generates active NFkB. +C3AR1 C3aR GPCR, family 1; Membrane protein, integral; Membrane protein, multi-pass; Receptor, GPCR Q16581 719 12p13.31 human S459-p 17548377 GILEAAFsEELTRST receptor desensitization, induced; molecular association, regulation transcription, inhibited ARRB2(INDUCES) 23077507 1 5 0 +PEX5 PEX5 Membrane protein, integral; Receptor, protein translocating P50542 5830 12p13.31 human K209-ub 22249280 VAKVDDPkLANSEFL molecular association, regulation; ubiquitination SQSTM1(INDUCES) 26344566 1 4 0 phosphorylated at S141 becomes ubiquitylated at K209, binding to SQSTM1, and directing the autophagosome to peroxisomes to induce pexophagy +Irs2 IRS2 Adaptor/scaffold; Motility/polarity/chemotaxis P81122 384783 8 A1.1|8 5.35 cM mouse S675-p 472256 SDDYMPMsPTSVSAP molecular association, regulation signaling pathway regulation PIK3R1(DISRUPTS) 23775122 2 22 5 +RRAGA RRAGA G protein regulator, misc. Q7L523 10670 9p22.1 human K142-ub 41159601 DQRDLIFkEREEDLR Gtr1_RagA molecular association, regulation; phosphorylation autophagy, induced; signaling pathway regulation NPRL3(INDUCES); Raptor(DISRUPTS); DEPDC5(INDUCES); NPRL2(INDUCES) 25936802 1 4 0 interaction with GATOR1 complex, regulates mTORC1 signaling, regulates p70S6K phosphorylation +NOS3 eNOS Amino Acid Metabolism - arginine and proline; EC 1.14.13.39; Oxidoreductase P29474 4846 7q36.1 human Y657-p 2811400 FGLGSRAyPHFCAFA Flavodoxin_1 enzymatic activity, inhibited 18483407; 19934023; 28444132 6 1 0 +Gch1 GCH1 Cofactor and Vitamin Metabolism - folate biosynthesis; EC 3.5.4.16; Hydrolase P22288 29244 15p14 rat S130-p 10428814 VKDIDMFsMCEHHLV GTP_cyclohydroI enzymatic activity, induced 19762783 1 0 0 +MYF5 Myf-5 DNA-binding; Transcription factor P13349 4617 12q21.31 human S49-p 457384 HKAELQGsDEDEHVR Basic activity, induced 9461343 1 0 0 +PXN PXN iso2 Adaptor/scaffold; Cell adhesion; Cytoskeletal; Motility/polarity/chemotaxis P49023-2 5829 12q24.23 human Y31-p 448785 FLSEETPySYPTGNH activity, induced; protein degradation; molecular association, regulation; phosphorylation cell cycle regulation; cell motility, altered; cytoskeletal reorganization; transcription, altered Src(INDUCES); CRKL(INDUCES) 15870699; 16491114; 17046825; 17574549; 18045996; 20628053; 7493940 49 8 64 Paxillin phosphorylation induces ERK activation.; essential for EGFR-mediated Erk1/2 activation and cell proliferation +AURKB AurB EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, Other; Protein kinase, Ser/Thr (non-receptor) Q96GD4 9212 17p13.1 human K202-sm 25087008 KVIHRDIkPENLLLG Pkinase phosphorylation; enzymatic activity, induced 21554500 1 1 0 induces phosphorylation at T232 +MYC Myc DNA-binding; Nucleolus; Oncoprotein; Transcription factor P01106 4609 8q24.21 human K445-sm 40724407 RREQLKHkLEQLRNS Myc-LZ protein degradation; ubiquitination transcription, inhibited 25895136 1 2 0 +TAL1 TAL1 DNA-binding; Oncoprotein; Transcription factor P17542 6886 1p33 human T90-p 457536 EARHRVPtTELCRPP protein degradation; molecular association, regulation; ubiquitination translation, induced CHIP(INDUCES) 15930267; 19406989 2 0 10 +TPM1 TPM1 Actin-binding; Motility/polarity/chemotaxis; Motor P09493 7168 15q22.2 human S283-p 451804 HALNDMTsI______ Tropomyosin molecular association, regulation carcinogenesis, inhibited; cell motility, inhibited; cytoskeletal reorganization TNNT1(DISRUPTS); TPM1(INDUCES); Actinfilin(INDUCES); Actinfilin(DISRUPTS) 17895359; 23157718; 33389411 11 15 94 induces interaction with actin at lower pH and decreases interaction at pH 7.3; Induce actin fibers formation; decreases cancer cells migration through the endothelial barrier in response to H2O2 +Bcar1 P130Cas Adaptor/scaffold; Motility/polarity/chemotaxis Q63767 25414 19q12 rat Y762-p 448399 EGGWMEDyDYVHLQG CAS_C molecular association, regulation; phosphorylation Src(INDUCES); Lck(INDUCES); Fyn(INDUCES) 16245368; 8621540; 9360983 6 2 24 +PPIF PPIF Cyclophilin; EC 5.2.1.8; Isomerase; Mitochondrial P30405 10105 10q22.3 human S31-p 40256000 LPAARACsKGSGDPS enzymatic activity, induced apoptosis, inhibited 25650317 1 0 0 mitochondrial bioenergetics, organelle membrane potential +FSCN1 fascin Actin-binding; Cytoskeletal; Motility/polarity/chemotaxis Q16658 6624 7p22.1 human K471-ub 8102207 KVGGRYLkGDHAGVL Fascin cytoskeletal reorganization 27879315 1 4 5 fascin bundling activity +Gsc GSC DNA-binding; Transcription factor Q02591 14836 12 E|12 54.32 cM mouse K203-sm 2887205 KVHLREEkVEVWFKN Homeodomain transcription, inhibited 18336814 1 0 0 SUMO modification inhibition is promoter specific +Nfatc2 NFAT1 DNA-binding; Transcription factor Q60591 18019 2 H3|2 88.91 cM mouse S328-p 447853 PSKIWKTsPDPTPVS transcription, inhibited 11030334 0 18 0 +RBBP8 CtIP EC 3.1.-.-; Transcription, coactivator/corepressor Q99708 5932 18q11.2 human T693-p 1868101003 ETVDMDCtLVSETVL cell cycle regulation; DNA repair, inhibited 30202980 1 0 0 supress DSB end resection +CTNND1 CTNND1 Actin-binding; Adaptor/scaffold; Cell adhesion; G protein regulator, misc.; Motility/polarity/chemotaxis O60716 1500 11q12.1 human T310-p 450457 GTARRTGtPSDPRRR molecular association, regulation; intracellular localization carcinogenesis, induced; cell motility, induced; cell adhesion, inhibited SMURF1(INDUCES); CDH1(DISRUPTS) 26302406; 30808747; 32010791; 32589661 10 7 28 +LATS2 LATS2 EC 2.7.11.1; KINASE; Kinase, protein; Nuclear receptor co-regulator; Protein kinase, AGC; Protein kinase, Ser/Thr (non-receptor); Tumor suppressor Q9NRM7 26524 13q12.11 human T1041-p 31843001 EHAFYEFtFRRFFDD Pkinase_C activity, induced; phosphorylation; enzymatic activity, induced carcinogenesis, inhibited; cell growth, inhibited; signaling pathway regulation 24362629; 30800215; 34465890 7 0 0 induces PRPS1 phosphorylation; Hippo pathway; in SAS cell line +Lpin1 LPIN1 EC 3.1.3.4; Phosphatase, lipid Q91ZP3 14245 12 A1.1|12 7.9 cM mouse S487-p 62856003 GIDSGVEsTSDSLRD molecular association, regulation BTRC(INDUCES) 28049764 1 0 0 +BBC3 PUMA Apoptosis; Mitochondrial Q9BXH1 27113 19q13.32 human Y58-p 29674706 PTLLPAAyLCAPTAP PUMA protein degradation; intracellular localization cell growth, induced; apoptosis, inhibited 24236056 1 0 0 +Dab1 DAB1 iso2 Adaptor/scaffold P97318-2 13131 4 C6|4 47.79 cM mouse T484-p 479421 PSTNSPPtPAPRQSS phosphorylation 16529723 1 0 0 inhibits tyrosine phosphorylation +HMGB1 HMGB1 DNA repair, damage; Nuclear receptor co-regulator P09429 3146 13q12.3 human T51-p 36840087 KCSERWKtMSAKEKG HMG_box_2 molecular association, regulation RPS3(INDUCES) 35632744 1 2 0 inducees HMGB1 secretion +BLM BLM DNA repair, damage; DNA replication; EC 3.6.4.12; Helicase P54132 641 15q26.1 human K331-sm 2293706 DLDTSDRkEDVLSTS BLM_N intracellular localization; phosphorylation chromatin organization, altered 15829507; 31171703 3 2 0 localization to PML bodies determined by the ratio of SUMO and SIM in telomere clustering scaffolds; inhibits phosphorylation of H2AX +KCNA4 Kv1.4 Channel, potassium; Membrane protein, integral; Membrane protein, multi-pass P22459 3739 11p14.1 human T601-p 456509 LKKFRSStSSSLGDK protein degradation 15955806 1 0 0 phosphorylation of site induces endocytosis of the Kv1.4 channel. +FBXO22 FBXO22 Ligase; UBIQUITIN LIGASE; Ubiquitin conjugating system; Ubiquitin ligase Q8NEZ5 26263 15q24.2 human S162-p 1875332204 VTPMGSGsNRPQEIE protein stabilization carcinogenesis, inhibited 34795058 1 1 0 induces PD-L1 degradation +Mefv pyrin Actin-binding Q9JJ26 54483 16 A1|16 2.18 cM mouse S241-p 455899 SGKKRPRsLEITTYS molecular association, regulation; activity, inhibited 14-3-3 epsilon(INDUCES) 27482109 8 7 0 dephosphorylation triggers 14-3-3 dissociation, activation, formation of an oligomeric Pyrin inflammasome complex +RAD52 RAD52 DNA repair, damage P43351 5893 12p13.33 human K262-ac 971232902 HQRKLRQkQLQQQFR molecular association, regulation; intracellular localization DNA repair, induced RFA2(INDUCES); RPA3(INDUCES); RAD51(INDUCES); RPA1(INDUCES) 29590107 1 1 0 accumulation of RAD52 at DSB sites +YBX1 YB-1 RNA processing; RNA splicing; RNA-binding; Transcription factor P67809 4904 1p34.2 human R205-m2 1876986200 MRRPYGRrPQYSNPP molecular association, regulation cell motility, induced; cell growth, induced; transcription, induced NFkB-p65(INDUCES) DNA(INDUCES) 32985589 1 1 0 +RRM2 RRM2 EC 1.17.4.1; Nucleotide Metabolism - purine; Nucleotide Metabolism - pyrimidine; Other Amino Acids Metabolism - glutathione; Oxidoreductase P31350 6241 2p25.1 human S20-p 457399 DPQQLQLsPLKGLSL transcription, induced; signaling pathway regulation 17693683 4 79 81 Beta-catenin-LEF/TCF transcriptional activity ; Wnt signaling pathway +MAP2K2 MEK2 EC 2.7.12.2; KINASE; Kinase, protein; Protein kinase, STE; Protein kinase, dual-specificity (non-receptor) P36507 5605 19p13.3 human S222-p 448073 VSGQLIDsMANSFVG Pkinase enzymatic activity, induced carcinogenesis, induced; cell growth, induced; signaling pathway regulation 19106095; 21893193; 34262144 62 12 83 +WASHC1 WASH1 A8K0Z3 100287171 9p24.3 human K220-ub 21357516 DAPLSISkREQLEQQ WASH_WAHD intracellular localization cytoskeletal reorganization 23452853 1 4 0 regulation of F-actin nucleation and retromer-mediated transport, endosomal protein recycling +Bmal1 BMAL1 DNA-binding; Transcription factor Q9WTL8 11865 7 F1|7 59.17 cM mouse K544-ac 1968606 DASSPGGkKILNGGT protein stabilization; molecular association, regulation; phosphorylation transcription, induced; transcription, inhibited; signaling pathway regulation; transcription, altered CRY1(INDUCES) 18075593; 18662547; 24089055 8 0 0 regulation of mammalian circadian clock through MTA1-SIRT1-BMAL1 axis +Ulk1 ULK1 Autophagy; EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, Other; Protein kinase, Ser/Thr (non-receptor) O70405 22241 5|5 F mouse S555-p 3176155 GLGCRLHsAPNLSDF activity, induced; molecular association, regulation; intracellular localization; enzymatic activity, induced; phosphorylation carcinogenesis, inhibited; autophagy, induced; autophagy, inhibited; autophagy, altered; transcription, altered; signaling pathway regulation 14-3-3 beta(INDUCES); RAB9A(INDUCES) 21205641; 21819378; 30332646; 30511961; 32854424; 33528041; 33779513; 34497121; 34598317; 34760883; 35115920 61 26 48 +BAG1 BAG1 Motility/polarity/chemotaxis; Nuclear receptor co-regulator Q99933 573 9p13.3 human K195-ub 1873691400 QKLIFKGkSLKEMET ubiquitin carcinogenesis, induced; cell growth, induced 12874020 1 0 0 +Mettl14 METTL14 EC 2.1.1.62; METHYLTRANSFERASE; Methyltransferase Q3UIK4 210529 3|3 G1 mouse R255-m1 1881467800 LRKWGYRrCEDICWI protein stabilization cell differentiation, induced 34145242 1 1 0 stabilizes the methyltransferase complex to its substrate RNA, mESC endoderm differentiation +MACC1 MACC1 Q6ZN28 346389 7p21.1 human Y793-p 1874020222 KPAYDFLyTWSAHYG phosphorylation carcinogenesis, induced; cell motility, induced; cell growth, induced; transcription, induced 34247190 1 1 0 +Ap2m1 AP2M1 Adaptor/scaffold; Vesicle P84091 11773 16|16 A3 mouse T156-p 448782 SQITSQVtGQIGWRR protein stabilization; protein conformation endocytosis, induced; signaling pathway regulation 31217281; 31905947 9 33 29 +PARP1 PARP1 DNA repair, damage; EC 2.4.2.30; Nuclear envelope; Nuclear receptor co-regulator; Nucleolus; Transferase P09874 142 1q42.12 human K508-ac 459005 AALSKKSkGQVKEEG molecular association, regulation transcription, induced NFkB-p105(INDUCES) 16204234 1 1 0 +Rela NFkB-p65 DNA-binding; Nuclear receptor co-regulator; Transcription factor Q7TQN4 309165 1q43 rat S468-p 451145 GVFTDLAsVDNSEFQ transcription, inhibited 21550382 22 0 0 +Prkaa1 AMPKA1 Autophagy; EC 2.7.11.1; EC 2.7.11.26; EC 2.7.11.27; EC 2.7.11.31; KINASE; Kinase, protein; Protein kinase, CAMK; Protein kinase, Ser/Thr (non-receptor) P54645 65248 2q16 rat Y441-p 457338 EWKVVNPyYLRVRRK AdenylateSensor enzymatic activity, inhibited 27626315 1 0 2 +ROCK1 ROCK1 EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, AGC; Protein kinase, Ser/Thr (non-receptor) Q13464 6093 18q11.1 human T455-p 2526076 EMEQKCRtSNIKLDK signaling pathway regulation 34530870 1 2 0 induces RhoA/ROCK1/MYPT1 signaling +KLF11 TIEG2 C2H2-type zinc finger protein; DNA-binding; Transcription factor O14901 8462 2p25.1 human S166-p 456011 GLEPVPSsPCRAKGT molecular association, regulation SIN3A(DISRUPTS) 12006497 1 0 0 +Elk1 ELK1 DNA-binding; Transcription factor A4GTP4 314436 Xq11 rat T160-p 2028401 MRSGLYStFTIQSLQ activity, inhibited transcription, inhibited SRF(DISRUPTS) 18088355 1 0 0 +EGR1 EGR1 C2H2-type zinc finger protein; DNA-binding; Transcription factor P18146 1958 5q31.2 human S196-p 11423701 PLSCAVPsNDSSPIY DUF3446 transcription, altered DNA(DISRUPTS) 8662759 1 0 0 +RPL11 RPL11 Motility/polarity/chemotaxis; Nucleolus; Ribosomal; Translation P62913 6135 1p36.11 human K38-ne 12067612 DRLTRAAkVLEQLTG Ribosomal_L5 protein stabilization; intracellular localization 19713960 1 0 0 +H3C1 H3 DNA-binding P68431 8350 6p22.2 human K4-ub 1880545300 ____ARTkQTARKST protein degradation carcinogenesis, induced; chromatin organization, altered; cell growth, induced; transcription, induced 28507061 1 0 0 +CEACAM1 CEACAM1 Cell adhesion; Immunoglobulin superfamily; Membrane protein, integral; Motility/polarity/chemotaxis P13688 634 19q13.2 human T492-p 473038 PNKMNEVtYSTLNFE apoptosis, altered; cytoskeletal reorganization 17192268 1 0 0 plays a role in cell polarization and lumen formation +BMAL1 BMAL1 DNA-binding; Transcription factor O00327 406 11p15.3 human S42-p 25230400 CNRKRKGsSTDYQES molecular association, regulation carcinogenesis, inhibited; cell growth, inhibited; cell motility, inhibited; transcription, inhibited DNA(DISRUPTS) 37123229 4 3 2 +Mtor mTOR Autophagy; EC 2.7.11.1; KINASE; Kinase, protein; Motility/polarity/chemotaxis; Protein kinase, Ser/Thr (non-receptor); Protein kinase, atypical Q9JLN9 56717 4 E2|4 78.76 cM mouse S1261-p 458285 PMKKLHVsTINLQKA phosphorylation cell growth, induced; signaling pathway regulation 19487463 5 29 5 induces phosphorylation of itself and of substrate, mTORC1 signaling +GJA1 GJA1 Channel, misc.; Membrane protein, integral; Membrane protein, multi-pass; Motility/polarity/chemotaxis P17302 2697 6q22.31 human S369-p 459208 RPSSRASsRASSRPR intracellular localization; protein conformation 23828237; 29259079 15 8 2 gap junction communication; trophoblast cell fusion and syncytial hormone production; assembly of Cx43 at the plasma membrane +KAT5 Tip60 ACETYLTRANSFERASE; Acetyltransferase; EC 2.3.1.48; Nuclear receptor co-regulator; Nucleolus Q92993 10524 11q13.1 human K268-ac 1872267900 YLCEFCLkYGRSLKC zf-MYST protein degradation apoptosis, inhibited 16001085 1 0 0 Tip60 targeting by HIV Tat +Arhgap12 ARHGAP12 GAP; GAP, Rac/Rho Q8C0D4 75415 18|18 A1 mouse T228-p 2424903 STEQMRAtTPPNQGR SH3-WW_linker cell cycle regulation; cell motility, altered 18515860 0 20 25 +RELA NFkB-p65 DNA-binding; Nuclear receptor co-regulator; Transcription factor Q04206 5970 11q13.1 human S42-p 25302155 RYKCEGRsAGSIPGE RHD_DNA_bind molecular association, regulation transcription, inhibited DNA(DISRUPTS) 27466442 1 2 1 +NGFR NGFR Membrane protein, integral; Receptor, misc. P08138 4804 17q21.33 human S303-p 10432300 PEGEKLHsDSGISVD molecular association, regulation; intracellular localization carcinogenesis, induced; cytoskeletal reorganization; cell growth, altered CLIM1(INDUCES) 12682012; 26119933 2 1 0 inactivation of Rho ; NGFR-mediated glioma invasion ; translocation to lipid rafts +Klf1 KLF1 C2H2-type zinc finger protein; DNA-binding; Transcription factor P46099 16596 8 41.3 cM|8 C3 mouse K284-ac 461016 CGHEGCGkSYSKSSH zf-C2H2 cell differentiation, induced; transcription, induced 12920040 3 0 0 +BMAL1 BMAL1 DNA-binding; Transcription factor O00327 406 11p15.3 human S17-p 12575203 STISDFMsPGPTDLL protein degradation transcription, altered 20049328 1 0 0 stabilization of BMAL1 protein leads to reduction in its transcription activation ability +FSCN1 fascin Actin-binding; Cytoskeletal; Motility/polarity/chemotaxis Q16658 6624 7p22.1 human Y23-p 6157484 LINCGNKyLTAEAFG Fascin cell growth, inhibited; cytoskeletal reorganization; cell motility, inhibited 28251354 1 2 1 reduce cell proliferation, cell migration and ?lopodia formation +Epor EPOR Membrane protein, integral; Receptor, cytokine P14753 13857 9 A3|9 7.93 cM mouse Y453-p 455531 PTPPHLKyLYLVVSD molecular association, regulation; receptor internalization, altered PIK3R2(INDUCES); PIK3R1(INDUCES) 19336760 6 0 0 required for optimal PIK3R1/2 binding +CYCS CYCS Apoptosis; Mitochondrial; Oxidoreductase; PHOSPHATASE; Protein phosphatase, Ser/Thr (non-receptor) P00004 100053958 horse K28-ac 1186601 VEKGGKHkTGPNLHG Cytochrom_C enzymatic activity, induced 19645667 1 3 10 +Irs2 IRS2 Adaptor/scaffold; Motility/polarity/chemotaxis P81122 384783 8 A1.1|8 5.35 cM mouse Y624-p 3597307 PKVAYNPyPEDYGDI molecular association, regulation INSR(DISRUPTS) 9195949 1 2 2 +EWSR1 EWS Oncoprotein; RNA-binding; Transcription, coactivator/corepressor Q01844 2130 22q12.2 human S266-p 448028 SSYGQQSsFRQDHPS intracellular localization transcription, induced 11313922 2 0 0 +RELA NFkB-p65 DNA-binding; Nuclear receptor co-regulator; Transcription factor Q04206 5970 11q13.1 human K218-me 31094534 EIFLLCDkVQKEDIE RHD_dimer molecular association, regulation transcription, induced DNA(INDUCES) 23904479 1 0 0 +DKC1 dyskerin EC 5.4.99.-; Isomerase; Lyase; Nucleolus; RNA processing; RNA-binding O60832 1736 Xq28 human K39-sm 31910300 HAEEFLIkPESKVAK protein stabilization; enzymatic activity, induced 23660516 1 0 0 +RAD52 RAD52 DNA repair, damage P43351 5893 12p13.33 human K177-ac 971232913 DYLRSLNkLPRQLPL Rad52_Rad22 molecular association, regulation; intracellular localization DNA repair, induced RFA2(INDUCES); RPA3(INDUCES); RAD51(INDUCES); RPA1(INDUCES) 29590107 1 1 0 accumulation of RAD52 at DSB sites +GLI1 GLI1 C2H2-type zinc finger protein; Oncoprotein; Transcription factor P08151 2735 12q13.3 human T1074-p 41595601 QRGSSGHtPPPSGPP protein degradation; molecular association, regulation; ubiquitination; intracellular localization; activity, inhibited carcinogenesis, inhibited; cell growth, inhibited; transcription, inhibited BTRC(INDUCES); SUFU(INDUCES) DNA(DISRUPTS) 26190112; 28562331; 29662197; 32102879 5 2 0 +MAP3K5 ASK1 EC 2.7.11.25; KINASE; Kinase, protein; Protein kinase, STE; Protein kinase, Ser/Thr (non-receptor) Q99683 4217 6q23.3 human Y718-p 458209 IPERDSRySQPLHEE Pkinase protein degradation; molecular association, regulation SOCS1(INDUCES) 19287004 1 0 0 SHP2 dephosphorylation of ASK1 Y798 disrupts binding of ASK1 to SOCS1 and induces apoptosis. +Smad1 SMAD1 DNA-binding; Transcription factor P97588 25671 19q11 rat S459-p 36133591 KVLTQMGsPHNPISS molecular association, regulation; intracellular localization cell cycle regulation Mad1(INDUCES) 30782962 1 1 0 recruits RZZ complex to the kinetochores +Wee2 WEE1B EC 2.7.10.2; KINASE; Kinase, protein; Protein kinase, Other; Protein kinase, Ser/Thr (non-receptor); Protein kinase, tyrosine (non-receptor) Q66JT0 381759 6|6 B1 mouse S15-p 456697 QGLNKKLsFSFCEED enzymatic activity, induced cell cycle regulation 23616086 3 0 0 +TBK1 TBK1 EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, Other; Protein kinase, Ser/Thr (non-receptor) Q9UHD2 29110 12q14.2 human S716-p 4271179 HILERFGsLTMDGGL phosphorylation; enzymatic activity, induced carcinogenesis, altered; cell growth, induced; signaling pathway regulation 31792381 2 14 6 +Creb1 CREB iso1 DNA-binding; Transcription factor P15337-1 81646 9q32 rat S121-p 451811 SVDSVTDsQKRREIL pKID protein degradation 16782881 12 0 0 required for PDGF-induced protein ubiquitination +Ephb1 EphB1 EC 2.7.10.1; KINASE; Kinase, protein; Membrane protein, integral; Protein kinase, TK; Protein kinase, tyrosine (receptor) P09759 24338 8q32 rat Y594-p 449995 GSPGMKIyIDPFTYE EphA2_TM molecular association, regulation NCK1(INDUCES) 23181695 5 16 117 +SLFN11 SLFN11 Q7Z7L1 91607 17q12 human T230-p 1869008604 FQEYVKRtIPEYVPA AlbA_2 activity, inhibited translation, induced 31395656 1 1 0 p24 expression and activity depend on S753 site +SNCA SNCA Adaptor/scaffold P37840 6622 4q22.1 human S129-p 448278 NEAYEMPsEEGYQDY Synuclein receptor internalization, induced; protein stabilization; molecular association, regulation; phosphorylation; activity, induced; ubiquitination; intracellular localization; protein conformation endocytosis, altered; exocytosis, induced; apoptosis, induced; apoptosis, inhibited; autophagy, altered RAB3A(INDUCES); SNCA(DISRUPTS); SNCAIP(INDUCES); PARK2(INDUCES); SNCA(INDUCES) DNA(DISRUPTS) 15944382; 16847063; 17652097; 18178617; 18343814; 18562315; 21400129; 21849493; 22079575; 25657004; 26719332; 31933723; 33979611; 34115198; 34220490; 34973339; 35353605; 35809645; 36162505; 36304930 143 7 0 +HAS2 HAS2 EC 2.4.1.212; Membrane protein, integral; Membrane protein, multi-pass; Motility/polarity/chemotaxis; Transferase Q92819 3037 8q24.13 human T328-p 1870773104 VLSLGYAtKYTARSK Chitin_synth_2 intracellular localization; enzymatic activity, induced 32993960 1 1 0 Regulates localization and membrane transport +KHDRBS1 KHDRBS1 RNA-binding Q07666 10657 1p35.2 human R320-m1 476773 LVRGTPVrGAITRGA intracellular localization 12529443 1 5 23 +MYCN N-Myc DNA-binding; Oncoprotein; Transcription factor P04198 4613 2p24.3 human S62-p 448222 LLPTPPLsPSRGFAE Myc_N protein degradation; protein stabilization; molecular association, regulation; ubiquitination; intracellular localization carcinogenesis, induced; cell growth, induced AurA(INDUCES) 19111882; 25100564; 25175806; 27571165; 34258104 6 20 13 inhibits ubiquitination +CIB1 CIB1 Cell adhesion; Motility/polarity/chemotaxis Q99828 10519 15q26.1 human S78-p 479918 ERICRVFsTSPAKDS carcinogenesis, induced; cell motility, induced 23503467 1 0 2 +SPTBN4 SPTBN4 Cytoskeletal; Motility/polarity/chemotaxis Q9H254 57731 19q13.2 human S2254-p 481487 RRPERQEsVDQSEEA protein degradation; molecular association, regulation cell growth, induced; transcription, induced; signaling pathway regulation STAT3(DISRUPTS) 34153319 1 8 0 induces ?IV-spectrin/STAT3 pathway +Dpysl2 CRMP-2 Microtubule-binding; Motility/polarity/chemotaxis P47942 25416 15p12 rat T514-p 454386 SVTPKTVtPASSAKT receptor recycling, inhibited; protein degradation; molecular association, regulation; activity, inhibited neural plasticity; cytoskeletal reorganization TUBA1A(DISRUPTS); TUBA1B(DISRUPTS); CRMP-4(DISRUPTS); endophilin A2(DISRUPTS); CRMP-1(DISRUPTS); ROCK2(DISRUPTS); SLC25A4(DISRUPTS) 15652488; 18220421; 24036111; 32848595; 33575839 33 36 35 regulates axonogenesis +PIM1 Pim1 EC 2.7.11.1; KINASE; Kinase, protein; Oncoprotein; Protein kinase, CAMK; Protein kinase, Ser/Thr (non-receptor) P11309 5292 6p21.2 human K169-sm 1873037706 GVLHRDIkDENILID Pkinase protein degradation; ubiquitination; enzymatic activity, induced 28620180 1 0 0 +Syngap1 SynGAP iso3 GAP; GAP, Ras Q9QUH6-3 192117 20p12 rat S781-p 18710211 KMLSVNKsVSMLDLQ DUF3498 molecular association, regulation; intracellular localization HRas(INDUCES) 21382555 1 1 1 +ABI3 ABI3 Adaptor/scaffold Q9P2A4 51225 17q21.32 human S213-p 4755282 SSAFSLAsAGSAEGV protein stabilization; molecular association, regulation carcinogenesis, induced; cell motility, induced FAT10(INDUCES) 36926204 1 2 0 +PHGDH PHGDH Amino Acid Metabolism - glycine, serine and threonine; Cell development/differentiation; EC 1.1.1.95; Oxidoreductase O43175 26227 1p12 human K58-ac 36311760 LIVRSATkVTADVIN 2-Hacid_dh protein degradation carcinogenesis, inhibited 32783943 1 2 0 +HIF3A HIF3A Transcription factor; Tumor suppressor Q9Y2N7 64344 19q13.32 human K570-ub 486276 SPMAGARkRTLAQSS protein degradation 12538644 1 0 0 +Stat5a STAT5A DNA-binding; Motility/polarity/chemotaxis; Oncoprotein; Transcription factor P42230 20850 11 D|11 63.77 cM mouse S128-p 456899 REANNCSsPAGVLVD phosphorylation transcription, induced DNA(INDUCES) 15863494 1 6 0 Phosphorylation of S127 or S128 is required for transcription. Phosphorylation of S127/S128 required for phosphorylation on Y694 and binding of DNA. +Map3k3 MEKK3 EC 2.7.11.25; KINASE; Kinase, protein; Protein kinase, STE; Protein kinase, Ser/Thr (non-receptor) Q61084 26406 11|11 E1 mouse S337-p 468184 DPRGRLRsADSENAL enzymatic activity, inhibited 12761204 2 32 46 +Ripk3 RIPK3 EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, Ser/Thr (non-receptor); Protein kinase, TKL Q9QZL0 56532 14|14 C3 mouse K264-ub 53415400 TPGLEKLkELMIHCW Pkinase protein degradation apoptosis, induced 26786097 1 0 0 induces necroptosis +MTHFD2 MTHFD2 Carbohydrate Metabolism - glyoxylate and dicarboxylate; Cofactor and Vitamin Metabolism - one carbon pool by folate; EC 1.5.1.15; EC 3.5.4.9; Hydrolase; Mitochondrial; Oxidoreductase P13995 10797 2p13.1 human K50-ac 461171 RKLAQQIkQEVRQEV THF_DHG_CYH protein stabilization carcinogenesis, induced; cell growth, induced 35349697 1 6 8 K50 acetylation supports NADPH production and breast cancer tumor growth, +TUBG1 TUBG1 Cytoskeletal; Motility/polarity/chemotaxis P23258 7283 17q21.2 human S385-p 34424909 MANHTSIsSLFERTC Tubulin_C molecular association, regulation; intracellular localization cell cycle regulation; transcription, altered TUBG1(DISRUPTS) 24942739 1 0 0 transient increase in nuclear TUBG1 +PAK2 PAK2 EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, STE; Protein kinase, Ser/Thr (non-receptor) Q13177 5062 3q29 human Y194-p 15413016 PDHTKSIyTRSVIDP enzymatic activity, induced 12215529 2 0 18 +Slc5a5 SLC5A5 Membrane protein, integral; Membrane protein, multi-pass; Transporter; Transporter, SLC family Q63008 114613 16p14 rat T49-p 990310 RSADDFFtGGRQLAA SSF protein conformation 17913707 1 1 0 +NFE2L2 NRF2 DNA-binding; Transcription factor Q16236 4780 2q31.2 human K438-ac 7106326 PVSPGHRkTPFTKDK molecular association, regulation transcription, induced DNA(INDUCES) 19273602 1 1 0 +CDH1 CDH1 Cell adhesion; Membrane protein, integral; Motility/polarity/chemotaxis; UBIQUITIN LIGASE; Ubiquitin ligase P12830 999 16q22.1 human Y755-p 456026 TRDNVYYyDEEGGGE endocytosis, induced 29311227 1 1 46 +APAF1 APAF Apoptosis O14727 317 12q23.1 human S268-p 23003805 LLTTRDKsVTDSVMG NB-ARC molecular association, regulation apoptosis, inhibited 14-3-3 epsilon(INDUCES); CYC1(DISRUPTS) 22246185 1 0 0 decreased cellular response to cytochrome c +Bmi1 BMI1 EC 6.3.2.-; Ligase; Motility/polarity/chemotaxis; Oncoprotein; UBIQUITIN LIGASE; Ubiquitin conjugating system; Ubiquitin ligase P25916 12151 2 A3|2 12.9 cM mouse S314-p 6150348 ASRPRKSsLNGSSAT cell cycle regulation; carcinogenesis, inhibited; cell growth, inhibited; transcription, induced 35650206 2 1 50 +Gria1 GluR1 Channel, calcium; Channel, ligand-gated; Membrane protein, integral; Membrane protein, multi-pass P19490 50592 10q22 rat S863-p 448566 TSTLPRNsGAGASGG activity, induced; receptor internalization, altered; intracellular localization; receptor internalization, inhibited neural plasticity; cell motility, induced GluR2(INDUCES) 10627585; 11943807; 12536214; 15630695; 16272153; 17472959; 21564097; 23461423; 26460013; 26626486; 28768764; 33593997; 35835216; 8663994 102 0 0 +ROCK2 ROCK2 EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, AGC; Protein kinase, Ser/Thr (non-receptor) O75116 9475 2p25.1 human S1379-p 3892345 NQSIRRPsRQLAPNK enzymatic activity, inhibited cytoskeletal reorganization 24610576 2 7 16 PGE2-dependent blockade of actomyosin fiber formation +NCF1 p47phox EC 1.-.-.-; Oxidoreductase P14598 653361 7q11.23 human S379-p 451498 DLILNRCsESTKRKL p47_phox_C molecular association, regulation; intracellular localization; protein conformation; enzymatic activity, induced; phosphorylation carcinogenesis, induced; cell growth, induced; signaling pathway regulation CYBA(INDUCES); p67phox(DISRUPTS); p40phox(DISRUPTS); TRAF4(INDUCES) 12056906; 15657040; 16297854; 22460559; 24632950; 24970888; 7657821 9 1 0 induces NOX1 activation and ROS generation +Foxo1 FOXO1A DNA-binding; Nuclear receptor co-regulator; Oncoprotein; Transcription factor Q9R1E0 56458 3 C|3 23.19 cM mouse S413-p 478368 PPNTSLNsPSPNYSK molecular association, regulation; intracellular localization transcription, inhibited DUSP6(INDUCES) 22503562; 22848439 4 1 0 +Wnk1 WNK1 EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, Other; Protein kinase, Ser/Thr (non-receptor) Q9JIH7 116477 4q42 rat S378-p 456474 LATLKRAsFAKSVIG Pkinase enzymatic activity, induced 12374799 3 7 0 +GMNN Geminin Cell cycle regulation; Motility/polarity/chemotaxis O75496 51053 6p22.3 human S184-p 25535401 EEETVEDsLVEDSEI Geminin molecular association, regulation HOXC9(INDUCES) 22615398 1 1 0 +Hsf1 HSF1 DNA-binding; Transcription factor P38532 15499 15 D3|15 35.95 cM mouse S415-p 455264 SALLDLFsPSVTMPD Vert_HS_TF intracellular localization 15661742 5 1 0 +Ctnnb1 CTNNB1 Actin-binding; Cell adhesion; Motility/polarity/chemotaxis; Nuclear receptor co-regulator; Oncoprotein; Transcription factor Q02248 12387 9 F4|9 72.19 cM mouse S33-p 447487 QQQSYLDsGIHSGAT activity, induced; protein degradation; ubiquitination cell differentiation, inhibited; carcinogenesis, inhibited; cell growth, inhibited; apoptosis, inhibited; cell motility, inhibited; transcription, altered 12370820; 34642308; 35013220; 35637461; 9233789 112 3 2 +BECN1 beclin 1 Adaptor/scaffold; Autophagy; Membrane protein, peripheral Q14457 8678 17q21.31 human K117-ub 14991107 ENLSRRLkVTGDLFD BH3 autophagy, induced 20501938 2 0 0 +HNRNPC hnRNP C1/C2 iso2 RNA splicing; RNA-binding; Spliceosome P07910-2 3183 14q11.2 human K237-sm 12057403 KKDETNVkMESEGGA molecular association, regulation DNA(DISRUPTS) 15082759 1 2 0 +Ripk4 ANKRD3 EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, Ser/Thr (non-receptor); Protein kinase, TKL Q9ERK0 72388 16|16 C4 mouse T184-p 2926100 SMDGLFGtIAYLPPE Pkinase enzymatic activity, induced transcription, altered 12676934 1 0 0 WT ANKRD3 and even mutant T184A can activate NFkB. +Cacna1e CACNA1E Channel, calcium; Membrane protein, integral; Membrane protein, multi-pass Q07652 54234 13q21 rat T365-p 455592 LEVLRRAtIKRSRTE activity, induced 15840578 1 0 9 potentiation of Ca(2+) currents +PHB1 PHB Apoptosis; Cell cycle regulation; Chaperone; Mitochondrial; Motility/polarity/chemotaxis; Nuclear receptor co-regulator; Oncoprotein; Transcription, coactivator/corepressor P35232 5245 17q21.33 human S121-gl 6374003 YDERVLPsITTEILK Band_7 phosphorylation 19238206 1 0 0 +PITPNM1 PITPNM1 Cell surface O00562 9600 11q13.2 human T794-p 451456 LEMLVPStPTSTSGA DDHD molecular association, regulation PLK1(INDUCES) 15125835 1 1 0 +NBN NBS1 Cell cycle regulation; DNA repair, damage O60934 4683 8q21.3 human S343-p 448605 TTPGPSLsQGVSVDE activity, induced; acetylation; phosphorylation cell cycle regulation; carcinogenesis, induced; DNA repair, induced; apoptosis, induced; chromatin organization, altered; cell growth, altered 10802669; 12861053; 14707289; 15733840; 17431132; 17526493; 18003706; 18644472; 24876101; 33568520 46 20 69 +VAV2 VAV2 GEF; GEF, Rac/Rho; Motility/polarity/chemotaxis P52735 7410 9q34.2 human Y142-p 452200 TENDDDVyRSLEELA intracellular localization cell adhesion, induced 24858039 2 7 71 localization to focal adhesions +Cdh2 CDH2 Cell adhesion; Membrane protein, integral; Motility/polarity/chemotaxis P15116 12558 18 A1|18 10.1 cM mouse Y852-p 450692 NDPTAPPyDSLLVFD CADH_Y-type_LIR molecular association, regulation SHC1(INDUCES) 10502299 2 0 0 +SREBF1 SREBP-1 iso3 DNA-binding; Membrane protein, integral; Membrane protein, multi-pass; Transcription factor P36956-3 6720 17p11.2 human T81-p 36533415 SPPQPAPtPLKMYPS transcription, induced 25353341 1 0 0 mRNA expression of central SREBP-1 target genes; Phosphorylation interferes with lipid metabolism and the secretory activity of liver cells. +ZNF322 ZNF322A C2H2-type zinc finger protein; Transcription factor Q6U7Q0 79692 6p22.2 human S396-p 114810401 ELSPPHAsEASQMS_ protein degradation; ubiquitination transcription, inhibited 28581525 1 0 0 +Fos Fos DNA-binding; Motility/polarity/chemotaxis; Oncoprotein; Transcription factor P12841 314322 6q31 rat S362-p 448481 AAAHRKGsSSNEPSS protein stabilization; protein conformation; phosphorylation cell cycle regulation; transcription, altered 12134156; 12629509; 17223854; 8622865 10 3 1 +Pten PTEN Carbohydrate Metabolism - inositol phosphate; EC 3.1.3.16; EC 3.1.3.48; EC 3.1.3.67; Motility/polarity/chemotaxis; Nuclear receptor co-regulator; PHOSPHATASE; Phosphatase, lipid; Tumor suppressor O08586 19211 19 C1|19 28.14 cM mouse S380-p 448313 EPDHYRYsDTTDSDP enzymatic activity, inhibited; intracellular localization cell cycle regulation 18332125; 24367090 40 0 0 +NF1 NF1 iso2 GAP; GAP, Ras; Motility/polarity/chemotaxis; Nucleolus; Tumor suppressor P21359-2 4763 17q11.2 human S2813-p 456018 AGSFKRNsIKKIV__ molecular association, regulation; activity, inhibited 14-3-3 beta(INDUCES) 14741381 1 1 12 +NR3C1 GR DNA-binding; Mitochondrial; Nuclear receptor; Transcription factor P04150 2908 5q31.3 human S203-p 447967 DLEFSSGsPGKETNE GCR molecular association, regulation; intracellular localization; activity, inhibited; phosphorylation transcription, induced; transcription, inhibited GRIP1(INDUCES) 17440046; 20047289; 24024586; 25847991 20 7 0 inhibits phosphorylation at site S211 +FBXL21P FBXL21 UBIQUITIN LIGASE; Ubiquitin ligase Q9UKT6 26223 5q31.1 human T33-p 1870414702 FYSSLNQtHTHTVLL protein degradation; molecular association, regulation; ubiquitination CUL1(INDUCES) 32937135 2 0 0 induces telethonin ubiquitination and degradation +Sox2 SOX2 Cell development/differentiation; DNA-binding; Transcription factor P48432 20674 3 A3|3 16.93 cM mouse K123-ub 49199202 RKTKTLMkKDKYTLP SOXp protein degradation cell differentiation, inhibited; transcription, inhibited 26292759 1 1 0 +APLNR APLNR GPCR, family 1; Membrane protein, integral; Membrane protein, multi-pass; Receptor, GPCR P35414 187 11q12.1 human S335-p 1870435802 QSRCAGTsHSSSGEK molecular association, regulation ARRB1(INDUCES); ARRB2(INDUCES) 32863206 1 1 0 BRET assay used for interaction +Esrp2 RBM35B RNA-binding Q8K0G8 77411 8|8 D3 mouse K530-ub 52473104 AAAQRCHkKMMKERY RRM_1 carcinogenesis, inhibited; RNA splicing, induced; cell growth, inhibited 26522722 1 0 0 +AKR1C1 AKR1C1 EC 1.1.1.112; EC 1.1.1.149; EC 1.3.1.20; Oxidoreductase; Xenobiotic Metabolism - metabolism by cytochrome P450 Q04828 1645 10p15.1 human K201-ub 12390205 HPYFNQRkLLDFCKS Aldo_ket_red molecular association, regulation carcinogenesis, induced; cell motility, induced; transcription, induced STAT3(INDUCES) 32104503 1 2 2 pro-metastatic, induces transcription of metastasis-related target genes (SOX2 and TWIST) +ITGB4 ITGB4 iso2 Cell adhesion; Membrane protein, integral; Motility/polarity/chemotaxis; Receptor, misc. P16144-2 3691 17q25.1 human Y1526-p 450142 DLLPNHSyVFRVRAQ fn3 molecular association, regulation cell adhesion, altered SHC1(INDUCES) 11044453 1 2 6 +Mov10 MOV10 EC 3.6.4.13; Helicase; RNA processing; RNA-binding; Spliceosome P23249 17454 3|3 F2.2 mouse S970-p 469850 LQGLSKLsPSTSGPR protein conformation RNA stability, inhibited 36871759 0 28 0 +KIF2C KIF2C Cancer Testis Antigen (CTA); Microtubule-binding; Motility/polarity/chemotaxis; Motor Q99661 11004 1p34.1 human S633-p 5779213 ELSSQMSsFNEAMTQ enzymatic activity, induced cell cycle regulation; cytoskeletal reorganization 25504441 1 5 3 1) Regulates catalytic activity of KIF2C 2) Activates KIF2C during mitosis. 3) Phosphorylation is required for microtubule depolymerization and proper spindle assembly. 4) Prevention of S632/S633 phosphorylation leads to chromosome segregation defects in anaphase. +Twist1 TWIST1 Cell development/differentiation; DNA-binding; Inhibitor; Transcription regulation P26687 22160 12 A3|12 14.81 cM mouse R34-me 40709501 QQPASGKrGARKRRS cell motility, induced 25847239 1 0 0 E-cadherin repression, cell migration and invasion +Ffar4 GPR120 GPCR, family 1; Lipid-binding; Membrane protein, integral; Membrane protein, multi-pass; Receptor, GPCR Q7TMA4 107221 19|19 C2 mouse T349-p 33638004 KGAIFTDtSVRRNDL receptor internalization, induced; molecular association, regulation ARR3(INDUCES) 26873857 2 1 0 +Rab3ip RAB3IP GEF; GEF, Rab Q62739 29885 7q22 rat S247-p 2023489 KTLVLSSsPTSPTQE Sec2p activity, induced; molecular association, regulation; protein conformation; enzymatic activity, induced exocytosis, induced RAB11A(DISRUPTS); RAB8A(INDUCES) 25535387 1 5 1 induces GEF activity of RAB3IP, induces RAB8 activity +AXIN1 axin 1 Adaptor/scaffold; Tumor suppressor O15169 8312 16p13.3 human S217-p 3174923 YTRTGSEsPKVCSDQ transcription, inhibited GSK3B(INDUCES) 17318175 1 5 0 +Cebpa C/EBP-alpha DNA-binding; Transcription factor P05554 24252 1q21 rat T222-p 449824 HLQPGHPtPPPTPVP activity, inhibited transcription, altered 16600022 8 0 0 In 3T3L1 preadipocytes, mutation of T222/T226 to alanines increased transcription at CBE-containing promoter (as compared to WT C/EBP-alpha). S230A had a similar effect as the double T->A mutation. The triple alanine mutation had the highest transcription of the reporter gene. S230A did not reduce T222/226 phosphorylation (although CHIR99021 inhibitor did). +Arhgap12 ARHGAP12 GAP; GAP, Rac/Rho Q8C0D4 75415 18|18 A1 mouse Y241-p 451932 GRPDSPVyANLQELK SH3-WW_linker cell cycle regulation; cell motility, altered 18515860 0 31 753 +TJP1 ZO1 Adaptor/scaffold; Motility/polarity/chemotaxis Q07157 7082 15q13.1 human T772-p 3653898 NHHLFTTtINLNSMN Guanylate_kin molecular association, regulation cell adhesion, inhibited occludin(DISRUPTS) 24338688 1 1 0 15(S)-HETE or 12(S)-HETE (high fat diet) -induced endothelial tight junction (TJ) disruption +F3 F3 Cell surface; Membrane protein, integral P13726 2152 1p21.3 human S295-p 3540201 ENSPLNVs_______ cell motility, altered 15630487 1 0 0 +MAPKAP1 Sin1 Adaptor/scaffold Q9BPZ7 79109 9q33.3 human S343-p 1876127002 DLDSTLEsQSAWEFC molecular association, regulation; phosphorylation apoptosis, inhibited ECT2(INDUCES) 34982576 1 1 0 induces AKT phosphorylation +SNAI1 Snail1 C2H2-type zinc finger protein; Transcription factor O95863 6615 20q13.13 human S104-p 455881 GKGSQPPsPPSPAPS activity, induced; protein degradation; protein stabilization; ubiquitination; intracellular localization carcinogenesis, induced; cell motility, induced; transcription, altered 15647282; 19923321; 20305697; 23644467 6 0 0 +Mapk7 ERK5 EC 2.7.11.24; KINASE; Kinase, protein; Protein kinase, CMGC; Protein kinase, Ser/Thr (non-receptor) Q9WVS8 23939 11|11 B2 mouse S496-p 455518 SRLRDGPsAPLEAPE sumoylation cell cycle regulation; endocytosis, altered; carcinogenesis, altered; cell motility, induced; apoptosis, induced; transcription, induced; transcription, inhibited 23243209; 29594152; 30586719; 37264926; 37307577 10 2 0 endothelial inflammation; alters phagocytosis; decreasesd eNOS expression and increased VCAM-1 expression; inflamation; induces NRF2 sumoylation +WAS WASP Adaptor/scaffold; Motility/polarity/chemotaxis P42768 7454 Xp11.23 human S483-p 449294 KRSRAIHsSDEGEDQ molecular association, regulation cytoskeletal reorganization ARPC3(INDUCES) 12769847 2 10 0 The double mutant (S483A/S484A) was used in this study. +Irs1 IRS1 Adaptor/scaffold; Motility/polarity/chemotaxis P35570 25467 9q34 rat S632-p 447506 NGDYMPMsPKSVSAP molecular association, regulation; enzymatic activity, inhibited PIK3R2(DISRUPTS); PIK3R1(DISRUPTS) 16354680; 8626671 41 26 1 +PHKB PHKB KINASE; Protein kinase, regulatory subunit P12798 100009137 rabbit S12-p 470137 TGLMAEVsWKVLERR molecular association, regulation; enzymatic activity, inhibited PHKG1(INDUCES) 17123541 2 0 0 +LMNA lamin A/C Cytoskeletal P02545 4000 1q22 human S404-p 478681 RSRGRASsHSSQTQG protein degradation; molecular association, regulation; intracellular localization cell cycle regulation; transcription, inhibited 14-3-3 beta(INDUCES) 23430973; 7925482 8 49 106 +RBL2 Rb-like 2 Transcription, coactivator/corepressor; Tumor suppressor Q08999 5934 16q12.2 human T1097-p 449742 SMIRTGEtPTKKRGI molecular association, regulation; intracellular localization cell cycle regulation KPNA1(DISRUPTS); E2F4(DISRUPTS) 11157749; 20857408 3 1 0 +BRCA1 BRCA1 EC 6.3.2.-; Nuclear receptor co-regulator; Transcription, coactivator/corepressor; Tumor suppressor; UBIQUITIN LIGASE; Ubiquitin conjugating system; Ubiquitin ligase P38398 672 17q21.31 human T509-p 448039 LKRKRRPtSGLHPED intracellular localization transcription, induced 17428466 3 6 73 +TRPV1 TRPV1 Channel, cation; Membrane protein, integral; Membrane protein, multi-pass; Receptor, misc. Q8NER1 7442 17p13.2 human T705-p 487542 WKLQRAItILDTEKS activity, induced 24920628 6 0 0 TRPV1 internalization, sensitivity to capsaicin, heat sensitivity +Slc6a5 SLC6A5 Membrane protein, integral; Membrane protein, multi-pass; Transporter; Transporter, SLC family P58295 171148 1q22 rat K751-ub 27209758 GRFIERLkLVCSPQP protein degradation; ubiquitination; intracellular localization endocytosis, induced; transcription, altered 23484054; 31628376 2 1 0 LNX2 mediated degradation was slower and seen after 48 hours, PKC regulation of SLC6A5 activity, modulation in the glycine transport activity of SLC6A5 +TERF2 TRF2 DNA repair, damage; DNA-binding Q15554 7014 16q22.1 human R63-me 10338220 AAGRRASrSSGRARR cell cycle regulation; cell growth, altered 19596784 1 0 0 +Syn1 SYN1 Vesicle O88935 20964 X A1.3|X 16.37 cM mouse Y301-p 478277 VVALTKTyATAEPFI Synapsin_C exocytosis, altered 20530578 2 0 2 +Smpd3 SMPD3 EC 3.1.4.12; Lipid Metabolism - sphingolipid; Membrane protein, integral; Phospholipase Q9JJY3 58994 8|8 D3 mouse K103-ub 1880099300 SYSRLEDkNPAGGAA protein degradation 36261549 1 0 0 +RPIA RPIA Carbohydrate Metabolism - pentose phosphate pathway; EC 5.3.1.6; Isomerase P49247 22934 2p11.2 human R42-m1 12195687 DLPGSHVrLPGRAQS enzymatic activity, induced carcinogenesis, induced; cell growth, induced 32157557 1 5 11 +CCDC88A girdin Actin-binding Q3V6T2 55704 2p16.1 human S1417-p 456477 INRERQKsLTLTPTR molecular association, regulation; intracellular localization carcinogenesis, induced; cell motility, induced; cell motility, altered; cell motility, inhibited; cytoskeletal reorganization ACTB(INDUCES) 16139227; 24662825; 30935690 9 18 1 +RAD51 RAD51 DNA repair, damage; Mitochondrial Q06609 5888 15q15.1 human Y315-p 448324 ETRICKIyDSPCLPE Rad51 molecular association, regulation cell cycle regulation; apoptosis, altered RAD51(DISRUPTS) 11684015; 15330855 4 0 1 +DDX1 DDX1 EC 3.6.4.13; Helicase; RNA-binding Q92499 1653 2p24.3 human K234-m1 58123001 LFPACVLkNAELKFN DEAD; SPRY molecular association, regulation L3MBTL iso4(INDUCES) 23583077 0 1 0 +Gabrg2 GABRG2 Channel, chloride; Channel, ligand-gated; Membrane protein, integral; Membrane protein, multi-pass; Transporter; Transporter, ion channel P22723 14406 11 A5|11 24.8 cM mouse K366-ub 11956714 VSNRKPSkDKDKKKK Neur_chan_memb protein degradation; receptor internalization, altered 19815531 1 0 0 regulation of the late endosomal/lysosomal trafficking of GABA receptors, regulation of synaptic transmission +Map2k1 MEK1 EC 2.7.12.2; KINASE; Kinase, protein; Protein kinase, STE; Protein kinase, dual-specificity (non-receptor) Q01986 170851 8q24 rat T292-p 448287 ETPPRPRtPGRPLSS Pkinase enzymatic activity, inhibited 8114697 14 6 0 +KCNQ1 Kv7.1 Channel, potassium; Membrane protein, integral; Membrane protein, multi-pass P51787 3784 11p15.5-p15.4 human S484-p 40556220 PHFMRTNsFAEDLDL KCNQ_channel activity, inhibited 29410121 1 2 0 reduction of currrent density +FOXP3 FOXP3 C2H2-type zinc finger protein; Cell cycle regulation; DNA-binding; Transcription factor Q9BZS1 50943 Xp11.23 human K227-ac 31914102 ADHLLDEkGRAQCLL FOXP-CC protein stabilization 23644046 1 0 0 +HDAC4 HDAC4 DEACETYLASE; Deacetylase; EC 3.5.1.98; Hydrolase; Nuclear receptor co-regulator; SUMO LIGASE P56524 9759 2q37.3 human S246-p 448488 FPLRKTAsEPNLKLR protein degradation; protein stabilization; molecular association, regulation; intracellular localization cell cycle regulation; carcinogenesis, induced; apoptosis, inhibited; transcription, induced; transcription, altered 14-3-3 beta(INDUCES); LATS2(DISRUPTS); 14-3-3 epsilon(INDUCES); YAP1(INDUCES) 10869435; 10958686; 16980613; 24904057; 28319066; 35780183 13 24 25 +EPHA2 EphA2 EC 2.7.10.1; KINASE; Kinase, protein; Membrane protein, integral; Protein kinase, TK; Protein kinase, tyrosine (receptor) P29317 1969 1p36.13 human Y930-p 457516 EHFMAAGyTAIEKVV SAM_1 molecular association, regulation; enzymatic activity, induced cell differentiation, altered; cell motility, induced GRB2(INDUCES); NCK1(INDUCES); VAV3(INDUCES); SHIP-2(INDUCES); PIK3R1(INDUCES) 18387945; 23358419; 24825902 3 3 13 +Kcnd2 Kv4.2 Channel, potassium; Membrane protein, integral; Membrane protein, multi-pass Q9Z0V2 16508 6 A2-A3.1|6 8.49 cM mouse T38-p 450461 PRQERKRtQDALIVL activity, induced 31311860 2 0 0 +DAP3 DAP3 Apoptosis; Mitochondrial; Nuclear receptor co-regulator P51398 7818 1q22 human T237-p 2226209 ITRVRNAtDAVGIVL DAP3 apoptosis, induced 18227431 1 0 0 +DLG4 PSD-95 Adaptor/scaffold P78352 1742 17p13.1 human S116-p 1875393402 GRLRVNDsILFVNEV PDZ molecular association, regulation Stargazin(INDUCES); NMDAR2B(INDUCES) Other(DISRUPTS) 34761188 0 1 0 inhibits binding to AVLX-144 +TAB1 TAB1 Activator; Motility/polarity/chemotaxis Q15750 10454 22q13.1 human S423-p 456222 QMVNGAHsASTLDEA activity, inhibited; phosphorylation 15590691; 19393267 6 0 0 inhibits phosphorylation of TAK1; inhibits TAK1 T187 phosphorylation +BCLAF1 BCLAF1 RNA-binding; Transcription factor Q9NYF8 9774 6q23.3 human S290-p 455931 RYSPSQNsPIHHIPS THRAP3_BCLAF1 intracellular localization; phosphorylation carcinogenesis, induced; DNA repair, induced; cell growth, induced; apoptosis, inhibited 34372878 1 80 31 regulates H2AX phosphorylation +MAT2A MAT2A Amino Acid Metabolism - cysteine and methionine; EC 2.5.1.6; Other Amino Acids Metabolism - selenoamino acid; Transferase P31153 4144 2p11.2 human K81-ac 11319857 RAAVDYQkVVREAVK S-AdoMet_synt_N protein degradation; ubiquitination; methylation carcinogenesis, inhibited; cell growth, inhibited 25925782 1 2 0 decreased gobal methylation +SCN5A SCN5A Channel, sodium; Membrane protein, integral; Membrane protein, multi-pass Q14524 6331 3p22.2 human S528-p 451569 KPRSSRGsIFTFRRR Na_trans_cytopl activity, induced 12242273; 24795344 4 2 1 +NR1H4 NR1H4 iso2 DNA-binding; Nuclear receptor Q96RI1-2 9971 12q23.1 human S135-p 4245801 VVCGDRAsGYHYNAL zf-C4 activity, induced; molecular association, regulation transcription, induced PGC-1 alpha(INDUCES) 18755856 1 0 0 +TP73 p73 DNA-binding; Transcription factor; Tumor suppressor O15350 7161 1p36.32 human S471-p 18944909 GEMSSSHsAQSMVSG protein stabilization; molecular association, regulation; intracellular localization carcinogenesis, induced; transcription, inhibited DNA(INDUCES) 21482671 1 0 0 p73 inhibits p53 transcriptional capabilities +Prag1 SGK223 EC 2.7.10.2; KINASE; Kinase, protein; Motility/polarity/chemotaxis; Protein kinase, Other; Protein kinase, Ser/Thr (non-receptor) D3ZMK9 306506 16q12.2 rat Y391-p 449701 AVQPEPIyAESAKRK molecular association, regulation; phosphorylation cytoskeletal reorganization CSK(INDUCES) 21873224 2 33 699 phosphorylation at the priming site of SGK223 decreases phosphorylation of Y530 and increases phosphorylation of Y419 of Src. +Ppp1r1b DARPP-32 Motility/polarity/chemotaxis; Protein phosphatase, regulatory subunit Q60829 19049 11|11 D mouse T34-p 448047 MIRRRRPtPAMLFRV DARPP-32 activity, induced; molecular association, regulation; phosphorylation; enzymatic activity, induced transcription, altered PPP1CA(INDUCES) 10669419; 16123776; 16971527; 17301223; 18496528; 36055413 67 6 44 Mutation of T34 impaired several behavioral responses to repeated cocaine administration, and abolished acute cocaine-regulated gene expression. +PLCG1 PLCG1 Carbohydrate Metabolism - inositol phosphate; EC 3.1.4.11; Motility/polarity/chemotaxis; Phospholipase P19174 5335 20q12 human Y1003-p 3954534 KGKKFLQyNRLQLSR PI-PLC-Y activity, inhibited signaling pathway regulation 12652307 1 1 30 +Bik BIK Apoptosis; Membrane protein, integral; Mitochondrial O70337 12124 15|15 E1 mouse T116-p 25171001 IWSWRVLtPGAWVSP bcl-2I13 ubiquitination 22388352 1 0 0 +HDAC6 HDAC6 DEACETYLASE; Deacetylase; EC 3.5.1.98; Nuclear receptor co-regulator; Ubiquitin conjugating system Q9UBN7 10013 Xp11.23 human S1035-p 29604201 DHQTPPTsPVQGTTP enzymatic activity, induced cell motility, induced 24089523 1 2 0 +Ppp1r9b Spinophilin Adaptor/scaffold; Protein phosphatase, regulatory subunit O35274 84686 10q26 rat S94-p 448728 SDRGVRLsLPRASSL molecular association, regulation; intracellular localization endocytosis, induced ADRA2A(DISRUPTS) 12417592; 18367453; 23965992 7 8 1 +CCDC88A girdin Actin-binding Q3V6T2 55704 2p16.1 human S1675-p 454193 HHKIKTGsPGSEVVT activity, induced; molecular association, regulation cell motility, induced G-alpha(s)(INDUCES); G-alpha i3(INDUCES); G-alpha i1(INDUCES) 26286990; 27621449; 27864364; 31363053 4 22 0 +Nos3 eNOS Amino Acid Metabolism - arginine and proline; EC 1.14.13.39; Oxidoreductase P70313 18127 5 A3|5 11.32 cM mouse S1176-p 447884 TSRIRTQsFSLQERQ molecular association, regulation; enzymatic activity, induced signaling pathway regulation CTNNB1(INDUCES) 16081872; 21540184; 22042868; 33770326; 34222255; 35017029; 35331293 217 18 7 BVR S-nitrosylation +EHMT2 EHMT2 Amino Acid Metabolism - lysine degradation; EC 2.1.1.43; METHYLTRANSFERASE; Methyltransferase; Methyltransferase, protein lysine Q96KQ7 10919 6p21.33 human T555-p 3827109 IPRGDGVtPPAGTAA transcription, inhibited 32611815 1 20 8 +FADD FADD Adaptor/scaffold; Apoptosis Q13158 8772 11q13.3 human K120-sm 62489903 RRLARQLkVSDTKID Death molecular association, regulation; intracellular localization CASP10(INDUCES); DRP1(INDUCES) 27799292 1 0 0 +PPP2R5B PPP2R5B Motility/polarity/chemotaxis; Protein phosphatase, regulatory subunit Q15173 5526 11q13.1 human S368-p 2655004 QVARCVSsPHFQVAE B56 phosphorylation 17200115 1 0 0 AKT phosphorylation +NHE-3 NHE3 Membrane protein, integral; Membrane protein, multi-pass; Transporter; Transporter, SLC family P26432 100009430 rabbit S607-p 450900 SLEQRRRsVRDAEDV intracellular localization; activity, inhibited 25480791 13 1 0 decreased surface expression of NHE3, phosphorylation of this site with other 2 sites are together necessary for activity inhibition +PAK1 PAK1 EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, STE; Protein kinase, Ser/Thr (non-receptor) Q13153 5058 11q13.5-q14.1 human T212-p 448176 VIEPLPVtPTRDVAT carcinogenesis, induced; cell growth, induced 31660987 17 27 19 Inhibitors decreased the tumor growth by inhibiting the phosphorylation +CCDC50 CCDC50 Inhibitor Q8IVM0 152137 3q28 human Y304-p 6377636 SSHKGFHyKH_____ phosphorylation apoptosis, inhibited; cell growth, altered 19059208 1 0 0 ; inhibits NF-kB activity; inhibits phosphorylation of IKKbeta through TNFalpha +Cldn6 Claudin-6 Cell adhesion; Membrane protein, integral; Membrane protein, multi-pass Q9Z262 54419 17|17 A3.3 mouse Y200-p 7792487 PRHYMACySTSVPHS cell adhesion, altered; signaling pathway regulation 31740618 1 2 17 +Vim Vimentin Cytoskeletal; Motility/polarity/chemotaxis P20152 22352 2 A1|2 10.04 cM mouse Y117-p 450350 LNDRFANyIDKVRFL Filament cytoskeletal reorganization 30696956 4 27 649 +CCNB1 CCNB1 Activator; Cell cycle regulation P14635 891 5q13.2 human K36-ub 603484742 TAPAATSkPGLRPRT protein degradation cell cycle regulation 12198152 1 2 0 +Il13ra1 IL13R Membrane protein, integral; Receptor, cytokine O09030 16164 X A3.3|X 20.49 cM mouse Y402-p 450931 HWKKYDIyEKQSKEE molecular association, regulation STAT3(INDUCES) 10409622 1 0 15 Ligand-induced phosphorylation of IL13R slightly increases its association with STAT3; results in tyrosine phosphorylation of STAT3. +Jdp2 JDP2 Nuclear receptor co-regulator; Transcription, coactivator/corepressor P97875 81703 12|12 D2 mouse T148-p 448312 VRTDSVRtPESEGNP protein degradation 21463260 3 11 5 +PI4K2A PI4K2A EC 2.7.1.67; Kinase, lipid; Motility/polarity/chemotaxis Q9BTU6 55361 10q24.2 human S47-p 468434 AAAGSGPsPPGSPGH molecular association, regulation endocytosis, inhibited BRSK1(INDUCES); VACAMKL(INDUCES); TRIM3(INDUCES); CENTG1(INDUCES) 37314927 2 73 6 +NEDD9 Cas-L Adaptor/scaffold; Motility/polarity/chemotaxis Q14511 4739 6p24.2 human Y189-p 448895 SHTTQGVyDIPPSSA cell motility, inhibited; cell adhesion, altered 23874939 1 10 111 Y189D may have reduced dynamics in comparison to WT. +SERPINA1 SERPINA1 Inhibitor; Secreted; Secreted, signal peptide P01009 5265 14q32.13 human T416-p 469611 MGKVVNPtQK_____ cell growth, altered 15498560 1 0 0 Phosphorylated C26 peptide did not induce cell increased proliferation and mitogenic action was increased 2 fold compared to unphosphorylated C26. +ITGB4 ITGB4 Cell adhesion; Membrane protein, integral; Motility/polarity/chemotaxis; Receptor, misc. P16144 3691 17q25.1 human Y1510-p 450141 STTLPRDySTLTSVS molecular association, regulation; phosphorylation carcinogenesis, induced; cell motility, induced; signaling pathway regulation Syk(INDUCES) 25531330; 31242404 6 11 166 induces expression of ITGB4 and ERK1/2, induces phosphorylation of MEK1 and ERK1/2, MEK1-ERK1/2 signaling pathway +LMTK2 Lmr2 EC 2.7.11.1; KINASE; Kinase, protein; Membrane protein, integral; Membrane protein, multi-pass; Protein kinase, Ser/Thr (non-receptor); Protein kinase, TK; Protein kinase, tyrosine (receptor) Q8IWU2 22853 7q21.3 human S1450-p 4957483 LQTSKYFsPPPPARS enzymatic activity, induced 22220831 1 12 9 +Wnk4 WNK4 EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, Other; Protein kinase, Ser/Thr (non-receptor) Q80UE6 69847 11|11 D mouse K451-ub 40323310 DGEKPGLkLWLRMED OSR1_C protein degradation 23576762 1 1 0 regulates electrolyte homeostasis and involved in Pseudohypoaldosteronism type II (PHAII) pathogenesis +Klf4 KLF4 C2H2-type zinc finger protein; DNA-binding; Transcription factor Q923V7 114505 5q24 rat T400-p 22996305 RKRTATHtCDYAGCG zf-C2H2 molecular association, regulation transcription, inhibited SP1(DISRUPTS) 22282354 1 0 0 +HSF1 HSF1 DNA-binding; Transcription factor Q00613 3297 8q24.3 human S363-p 455486 DTEGRPPsPPPTSTP Vert_HS_TF transcription, inhibited 25963659 6 34 42 under non-stressed conditions, upon heat shock S to A mutant showed 60% higher luciferase activity +Pxn PXN Adaptor/scaffold; Cell adhesion; Cytoskeletal; Motility/polarity/chemotaxis Q66H76 360820 12q16 rat S83-p 451113 YAHQQPPsPSPIYSS Paxillin cell adhesion, altered 14970194 7 40 44 +TNKS TNKS EC 2.4.2.30; Transferase O95271 8658 8p23.1 human S978-p 471333 VVSASLIsPASTPSC protein stabilization; intracellular localization; enzymatic activity, induced cell cycle regulation; cell growth, induced 21818122 2 0 0 +Mdm2 MDM2 EC 6.3.2.-; EC 6.3.2.19; Inhibitor; Ligase; NEDDYLATION LIGASE; Neddylation Ligase; Nucleolus; Oncoprotein; UBIQUITIN LIGASE; Ubiquitin conjugating system; Ubiquitin ligase P23804 17246 10 D2|10 66.32 cM mouse S394-p 447898 SQESDDYsQPSTSSS protein degradation; molecular association, regulation; phosphorylation cell growth, inhibited; transcription, induced p53(DISRUPTS) 27568562 15 2 0 strongly suppresses Myc oncogene-induced tumorigenesis ; S394 phosphorylation increased p53 activation (S15 phosphorylation) +H1-4 H1E DNA-binding P10412 3008 6p22.2 human K34-ac 3925584 SAGAAKRkASGPPVS molecular association, regulation chromatin organization, altered; transcription, induced TAF1(INDUCES) 22465951 1 1 1 +PAK5 PAK5 EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, STE; Protein kinase, Ser/Thr (non-receptor) Q9P286 57144 20p12.2 human S99-p 29574070 ISVTRSNsLRKESPP intracellular localization cell motility, induced 35969127 1 1 0 +SNX27 SNX27 Vesicle Q96L92 81609 1q21.3 human S51-p 486072 VRIVKSEsGYGFNVR PDZ receptor recycling, inhibited; molecular association, regulation; protein conformation PTHR(DISRUPTS); DGKZ(DISRUPTS); SEMA4C(DISRUPTS) 33605979 1 26 0 inhibits endocytic trafficking +STIM1 STIM1 Calcium-binding; Endoplasmic reticulum; Membrane protein, integral Q13586 6786 11p15.4 human T389-p 37049500 KIKKKRNtLFGTFHV SOAR activity, induced; protein conformation 25504574; 29326165 2 0 0 1) ARC channel activation 2) CRAC channel inhibition; induce an extension of the C-terminal helical region of the CC2 region of STIM1 and enables the selective activation of the ARC channels +ATP7B ATP7B EC 3.6.3.54; Hydrolase; Membrane protein, integral; Membrane protein, multi-pass; Transporter; Transporter, ion channel; Vesicle P35670 540 13q14.3 human S340-p 25786200 GSGTDHRsSSSHSPG intracellular localization; protein conformation 22898812 1 0 0 mutant does not return to TGN in response to copper depletion; S340/341A mutant shifts ATP7B from trans-Golgi Network (TGN) to vesicles +JAK2 JAK2 EC 2.7.10.2; KINASE; Kinase, protein; Oncoprotein; Protein kinase, TK; Protein kinase, tyrosine (non-receptor) O60674 3717 9p24.1 human Y221-p 451493 IRAKIQDyHILTRKR FERM_F2 enzymatic activity, induced carcinogenesis, induced; transcription, induced; signaling pathway regulation 34031055 14 5 1 CD44/JAK2/STAT2/CDA signaling pathway +STXBP5L STXBP5L Q9Y2K9 9515 3q13.33 human S772-p 34668138 SSGKRLSsADVSKVN protein degradation 25002582 1 1 0 ; in a multiple residue S->D mutant +CSNK1E CK1E EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, CK1; Protein kinase, Ser/Thr (non-receptor) P49674 1454 22q13.1 human T407-p 453420 SRIPASQtSVPFDHL enzymatic activity, inhibited 10542239; 12223474 2 6 1 some subset of these 8 sites +Csf1r CSFR EC 2.7.10.1; KINASE; Kinase, protein; Membrane protein, integral; Oncoprotein; Protein kinase, TK; Protein kinase, tyrosine (receptor) P09581 12978 18 E1|18 34.41 cM mouse Y974-p 455527 PLLQPNNyQFC____ molecular association, regulation cell differentiation, altered; cytoskeletal reorganization CBL(INDUCES) 11850825; 18519746 2 0 0 +Dusp4 DUSP4 EC 3.1.3.16; EC 3.1.3.48; PHOSPHATASE; Protein phosphatase, dual-specificity Q8BFV3 319520 8|8 A4 mouse T361-p 25123903 LRERGKAtPTPTSQF protein stabilization 22430215 1 0 0 +SSTR2 SSTR2 GPCR, family 1; Membrane protein, integral; Membrane protein, multi-pass; Receptor, GPCR P30874 6752 17q25.1 human T354-p 7652101 KSRLNETtETQRTLL receptor internalization, induced; receptor desensitization, induced; receptor recycling, induced 24565897; 24637622 9 0 1 +CD8A CD8A Membrane protein, integral P01732 925 2p11.2 human S231-p 25286619 SGDKPSLsARYV___ carcinogenesis, inhibited; signaling pathway regulation 30131370 0 2 1 +GMNN Geminin Cell cycle regulation; Motility/polarity/chemotaxis O75496 51053 6p22.3 human S200-p 475942 TCAEGTVsSSTDAKP apoptosis, altered 17261582 1 0 0 regulates geminin cleavage by caspase-3 +Mos MOS EC 2.7.11.1; KINASE; Kinase, protein; Oncoprotein; Protein kinase, Other; Protein kinase, Ser/Thr (non-receptor) P00536 17451 4 A1|4 2.16 cM mouse S3-p 448658 _____MPsPLSLCRY protein conformation; enzymatic activity, induced 9632642 3 1 0 in vitro +PRICKLE1 PRICKLE1 Unknown function Q96MT3 144165 12q12 human T370-p 55571503 LSGNADDtLSRKLDD molecular association, regulation cell motility, induced; cell growth, induced RICTOR(INDUCES) 27184734 1 0 0 +PXN PXN Adaptor/scaffold; Cell adhesion; Cytoskeletal; Motility/polarity/chemotaxis P49024 395832 chicken Y31-p 448785 FLTEETPySYPTGNH molecular association, regulation cytoskeletal reorganization CDK6(INDUCES); CRK(INDUCES) 10825157; 12949231 49 8 64 +KIR3DL1 KIR3DL1 Membrane protein, integral; Receptor, misc. P43629 3811 19q13.42 human S415-p 990302 QRKITRPsQRPKTPP activity, induced; receptor internalization, altered 17911614 1 0 0 +CD8B CD8B iso4 Membrane protein, integral P10966-4 926 2p11.2 human K215-ub 2884407 KFNIVCLkISGFTTC receptor internalization, induced; protein degradation 18490743 1 0 0 +MAP2K5 MEK5 EC 2.7.12.2; KINASE; Kinase, protein; Protein kinase, STE; Protein kinase, dual-specificity (non-receptor) Q13163 5607 15q23 human S311-p 448621 VSTQLVNsIAKTYVG Pkinase molecular association, regulation; intracellular localization; enzymatic activity, induced ERK5(DISRUPTS) 14583600; 7759517 3 5 0 +UBA52-RPS27A-UBB-UBC ubiquitin Ubiquitin-like modifier P62991 mouse K29-ub 3135200 TIENVKAkIQDKEGI ubiquitin cell cycle regulation; cell growth, inhibited; transcription, inhibited 31135381 18 20 136 USP16 regulates T cell proliferation and cell-cycle entry; Ubiquitination of PPP3CB impairs NFAT recruitment and transcription of NFAT-targeted genes +CASQ1 calsequestrin 1 Calcium-binding; Mitochondrial P07221 100009095 rabbit T381-p 451337 VLEGEINtEDDDDED Calsequestrin molecular association, regulation ASPH(INDUCES) 19230141 3 0 0 increases Ca2+ binding capacity of calsequestrin 1 +ADRA1B ADRA1B GPCR, family 1; Membrane protein, integral; Membrane protein, multi-pass; Receptor, GPCR P18841 101843941 hamster S408-p 451005 RKDSLDDsGSCMSGS receptor desensitization, altered 9353340 1 2 2 +YWHAB 14-3-3 beta Adaptor/scaffold P31946 7529 20q13.12 human K117-ac 466016 NATQPESkVFYLKMK 14-3-3 molecular association, regulation SYNPO(DISRUPTS) 23840712 1 2 26 +Npy1r NPY1R GPCR, family 1; Membrane protein, integral; Membrane protein, multi-pass; Receptor, GPCR P21555 29358 16p14 rat T361-p 455139 MHTDVSKtSLKQASP receptor desensitization, altered; receptor internalization, altered 15576634 1 0 0 may be an artifact of the truncation mutants +Cryaa CRYA1 Chaperone; Heat shock protein P24623 24273 20p12 rat S171-p 452108 FSGPKVQsGLDAGHS HSP20 apoptosis, inhibited 22414529 5 5 0 cytoprotective effect +PDE3A PDE3A EC 3.1.4.17; Membrane protein, integral; Membrane protein, multi-pass; Nucleotide Metabolism - purine; Phosphodiesterase Q14432 5139 12p12.2 human S292-p 471415 VFKRRRRsSSVVSAE molecular association, regulation; enzymatic activity, induced SERCA2(INDUCES); AKAP7(NOT_REPORTED) 25593322 2 2 9 +Nfe2l2 NRF2 DNA-binding; Transcription factor Q60795 18024 2 C3|2 44.75 cM mouse Y568-p 460703 RDEDGKPySPSEYSL protein degradation; molecular association, regulation; ubiquitination; intracellular localization Exportin-1(INDUCES) 16513647; 17403689 6 1 1 nuclear export; required for nuclear export of Nrf2 +EPHA3 EphA3 EC 2.7.10.1; KINASE; Kinase, protein; Membrane protein, integral; Protein kinase, TK; Protein kinase, tyrosine (receptor) P29320 2042 3p11.1 human Y779-p 448910 EDDPEAAyTTRGGKI PK_Tyr_Ser-Thr molecular association, regulation; enzymatic activity, induced cytoskeletal reorganization; cell adhesion, altered CRK(INDUCES) 11870224 3 33 700 +TSC2 TSC2 Cell cycle regulation; GAP; GAP, misc.; Nuclear receptor co-regulator; Tumor suppressor P49815 7249 16p13.3 human S939-p 448501 SFRARSTsLNERPKS molecular association, regulation; intracellular localization; activity, inhibited; phosphorylation apoptosis, inhibited; signaling pathway regulation; transcription, altered 14-3-3 beta(INDUCES); 14-3-3 zeta(INDUCES); 14-3-3 epsilon(INDUCES); 14-3-3 gamma(INDUCES) 12438239; 15342917; 16636147; 16702951; 20169078; 27451907; 30684133 25 34 50 mTORC1 activation and signaling +RELA NFkB-p65 DNA-binding; Nuclear receptor co-regulator; Transcription factor Q04206 5970 11q13.1 human T505-p 455490 EAITRLVtGAQRPPD cell growth, inhibited; apoptosis, inhibited; cytoskeletal reorganization; cell motility, inhibited; transcription, altered; transcription, inhibited 15775976; 21737676 4 0 0 induces NOXA gene expression +Tpt1 TPT1 Calcium-binding; Microtubule-binding P63029 116646 15q11 rat S15-p 40584902 ISHDELFsDIYKIRE TCTP intracellular localization 25854427 1 1 0 +EPOR EPOR Membrane protein, integral; Receptor, cytokine P19235 2057 19p13.2 human Y309-p 3133300 GNFQLWLyQNDGCLW phosphorylation cell growth, altered 15878737 1 0 0 +KIT Kit EC 2.7.10.1; KINASE; Kinase, protein; Membrane protein, integral; Oncoprotein; Protein kinase, TK; Protein kinase, tyrosine (receptor) P10721 3815 4q12 human Y570-p 448015 INGNNYVyIDPTQLP activity, induced; molecular association, regulation; enzymatic activity, induced cell growth, altered CTK(INDUCES); SHP-1(INDUCES) 20147452; 21887372; 9038210; 9528781 9 3 12 +TP73 p73 DNA-binding; Transcription factor; Tumor suppressor O15350 7161 1p36.32 human K327-ac 460606 AKNGAASkRAFKQSP molecular association, regulation cell growth, inhibited; apoptosis, induced; transcription, induced DNA(INDUCES) 11804596 1 1 0 induces binding to p53AIP1 gene and induces its transcription, but retains an intact ability to regulate genes. +FOXM1 FOXM1 DNA-binding; Transcription factor Q08050 2305 12p13.33 human K63-ac 57807004 CKFPAGIkIINHPTM activity, induced; protein stabilization; molecular association, regulation; phosphorylation carcinogenesis, induced; cell growth, induced; transcription, induced DNA(NOT_REPORTED) 27542221 1 1 0 +SGO1 SGO1 Cell cycle regulation Q5FBB7 151648 3p24.3 human T346-p 15406076 LEEGVHLtPFRQKVS molecular association, regulation; intracellular localization cell cycle regulation PPP2CA(INDUCES); STAG1(INDUCES); STAG2(INDUCES) 23242214; 24055156 2 4 6 +Ptk2 FAK EC 2.7.10.2; KINASE; Kinase, protein; Protein kinase, TK; Protein kinase, tyrosine (non-receptor) P34152 14083 15 D3|15 33.94 cM mouse S732-p 450196 SSEGFYPsPQHMVQT intracellular localization cytoskeletal reorganization 12941275 5 1 0 Expression of GFP-FAK-S732A mutant results in altered neuronal positioning, abnormal nuclear morphology, and altered nuclear movement in cultured neurons. +ZRANB1 ZRANB1 DEUBIQUITINASE; EC 3.4.19.12; Ligase; Protease; Ubiquitin conjugating system; Ubiquitin-specific protease Q9UGI0 54764 10q26.13 human T35-p 50840530 RAQRPSGtIITEDPF activity, induced signaling pathway regulation 30686098 1 2 0 +Gria1 GluR1 Channel, calcium; Channel, ligand-gated; Membrane protein, integral; Membrane protein, multi-pass P19490 50592 10q22 rat K837-ac 206219719 YKSRSESkRMKGFCL protein stabilization; ubiquitination; receptor internalization, inhibited neural plasticity 28793258 1 0 0 inhibits ubiquitination; impaired learning and memory +FPR1 FPR1 GPCR, family 1; Membrane protein, integral; Membrane protein, multi-pass; Motility/polarity/chemotaxis; Receptor, GPCR P21462 2357 19q13.41 human T331-p 450666 LTEDSTQtSDTATNS receptor desensitization, altered; receptor internalization, altered 10514456 2 1 0 +PAK4 PAK4 EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, STE; Protein kinase, Ser/Thr (non-receptor) O96013 10298 19q13.2 human S474-p 448023 KEVPRRKsLVGTPYW Pkinase intracellular localization; enzymatic activity, induced carcinogenesis, induced; cell growth, altered 11668177; 20926745; 29849120; 35969127 13 66 140 +Ezh2 EZH2 EC 2.1.1.43; METHYLTRANSFERASE; Methyltransferase; Methyltransferase, protein lysine Q61188 14056 6 B2.3|6 22.92 cM mouse T367-p 466987 NNSSRPStPTISVLE protein stabilization; molecular association, regulation; methylation; intracellular localization; protein conformation carcinogenesis, induced; cell growth, induced; transcription, altered SUZ12(INDUCES); EED(INDUCES) 37069142 5 21 45 induces H3 methylation +CCP110 CP110 Cell cycle regulation O43303 9738 16p12.3 human S516-p 23095734 ASSQCIAsPNFGTVS intracellular localization cell cycle regulation 12361598 1 3 1 +Tlr4 TLR4 Membrane protein, integral; Receptor, misc. Q9QUK6 21898 4 C1|4 34.66 cM mouse Y749-p 1881596602 SRWCIFEyEIAQTWQ protein stabilization transcription, induced 37058370 1 1 0 +PASK PASK EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, CAMK; Protein kinase, Ser/Thr (non-receptor) Q96RG2 23178 2q37.3 human T307-p 1868450201 VGRARDGtTFPLSLK phosphorylation; enzymatic activity, induced cell differentiation, induced; signaling pathway regulation 31072927 1 0 0 mTORC1 signaling for muscle cell differentiation, Wdr5 phosphorylation +Akt1 Akt1 EC 2.7.11.1; KINASE; Kinase, protein; Oncoprotein; Protein kinase, AGC; Protein kinase, Ser/Thr (non-receptor) P31750 11651 12 F1|12 61.2 cM mouse S122-p 3189784 EETMDFRsGSPSDNS carcinogenesis, induced; signaling pathway regulation 32473126 0 15 0 FAK-p-HGFR-p-Akt-p-p65-CCL2 FAK-p-HGFR-p-Akt-p-p65-CCL2 +NEDD1 NEDD1 Cell cycle regulation Q8NHV4 121441 12q23.1 human S565-p 25533008 SVTAGVAsSLSEKIA molecular association, regulation cytoskeletal reorganization TUBG1(INDUCES) 22595525 1 1 0 Promote NEDD1 activity; regulates spindle assembly in mitosis +HIF1A HIF1A Autophagy; DNA-binding; Transcription factor Q16665 3091 14q23.2 human S668-p 11073382 DTQSRTAsPNRAGKG protein stabilization cell motility, induced; cell growth, induced 24189531 1 1 1 enhances invasion, angiogenesis, and tumor growth +Flot2 FLOT2 Cell adhesion Q9Z2S9 83764 10q25 rat Y27-p 1270905 CGSDYKQyVFGGWAW Band_7 intracellular localization cell motility, altered; cytoskeletal reorganization 17213334 1 0 0 +PAGE4 PAGE4 Cancer Testis Antigen (CTA) O60829 9506 Xp11.23 human S9-p 63280101 SARVRSRsRGRGDGQ GAGE protein conformation 28289210 1 1 0 +FGFR1 FGFR1 EC 2.7.10.1; KINASE; Kinase, protein; Membrane protein, integral; Oncoprotein; Protein kinase, TK; Protein kinase, tyrosine (receptor) P11362 2260 8p11.23 human Y154-p 448774 NRMPVAPyWTSPEKM protein degradation; receptor desensitization, altered; receptor internalization, altered cytoskeletal reorganization 10652257; 7516330 4 1 0 +FOXN3 FOXN3 DNA-binding; Transcription factor O00409 1112 14q31.3-q32.11 human S85-p 454694 ESVLRSVsPVQDLDD activity, induced; protein degradation; molecular association, regulation; ubiquitination signaling pathway regulation hnRNP U(DISRUPTS) 36794705 1 14 3 induces NFKB activity and signaling +DDX21 DDX21 EC 3.6.4.13; Helicase; Nucleolus; RNA processing; RNA-binding Q9NR30 9188 10q22.1 human S171-p 452490 SEAASEEsNSEIEQE intracellular localization RNA splicing, inhibited 18703060 1 34 10 +BRD4 BRD4 KINASE; Kinase, protein; Protein kinase, Ser/Thr (non-receptor); Protein kinase, atypical O60885 23476 19p13.12 human R179-m1 57691840 MIVQAKGrGRGRKET carcinogenesis, induced; DNA repair, induced; cell growth, induced; transcription, induced 36475791 1 3 0 +H3c1 H3 DNA-binding P68433 360198 13|13 A3.1 mouse K4-m3 1458621 ____ARTkQTARKST Histone intracellular localization; methylation; phosphorylation; enzymatic activity, induced cell differentiation, inhibited; cell cycle regulation; carcinogenesis, induced; endocytosis, altered; transcription, induced; transcription, altered; cell differentiation, altered; chromatin organization, altered; cell differentiation, induced; cell adhesion, altered; transcription, inhibited 17967893; 18039862; 18728284; 19567879; 19703992; 19779457; 19915707; 20393567; 20574709; 20935159; 22237151; 25519132; 25751424; 26716510; 32341358; 33195484; 33971063; 34608337; 35640597; 35810562 178 10 0 K885A mutant of SETDB1 inhibits enzyme activity but not its localization to target genes, mutant represses some adipogenic genes and inhibits adipocyte differentiation as does WT, but others arenot repressed and don't may not require its enzymatic activity and other H3K9 methyltransferases may be able to compensate. ; H2AK119ub1 at the actively transcribed genes marked by H3K4me3 ; PRC1 mediated repression is achieved by controlling transcriptional burst frequency; DYRK1A inhibition decreases KAT6A and WDR82 phosphorylation and induces H3K27ac and H3K4me3 modi?cation, pharmacological inhibition or genetic deletion of DYRK1A promotes cardiomyocyte cell cycle activation and cardiac repair; axon guidance; modulated during differentiation and epigenitic reprograming +Dusp6 DUSP6 EC 3.1.3.16; EC 3.1.3.48; Motility/polarity/chemotaxis; PHOSPHATASE; Protein phosphatase, dual-specificity Q9DBB1 67603 10|10 D1 mouse S197-p 455266 SATDSDGsPLSNSQP protein degradation signaling pathway regulation 22521266 5 0 0 represses expression of gluconeogenic genes and glucose output +PAWR PAR-4 Apoptosis Q96IZ0 5074 12q21.2 human S231-p 476476 GRYKSTTsVSEEDVS apoptosis, inhibited 24457960 1 15 18 +Ahr AHR DNA-binding; Transcription factor P30561 11622 12 A3|12 15.78 cM mouse S67-p 451013 INKLDKLsVLRLSVS HLH intracellular localization 14985336 1 0 0 +TOB1 TOB1 Adaptor/scaffold; Cell cycle regulation P50616 10140 17q21.33 human S152-p 455535 PASSVSSsPSPPFGH activity, inhibited cell cycle regulation; cell growth, inhibited; cell growth, altered 12050114; 12151396; 22252318 3 0 0 promote mRNA deadenylaion and decay and the ability to suppress proliferation; the antiproliferative activity of TOB1 is inhibited by phosphorylation.; the antiproliferative function of TOB1 is inhibited by phosphorylation. +DDHD1 DDHD1 EC 3.1.1.-; Phospholipase Q8NEL9 80821 14q22.1 human S727-p 465585 TIPSPVTsPVLSRRH DDHD intracellular localization 34089703 2 10 0 +Ahcyl2 AHCYL2 Amino Acid Metabolism - cysteine and methionine; EC 3.3.1.1; Hydrolase; Motility/polarity/chemotaxis; Other Amino Acids Metabolism - selenoamino acid Q68FL4 74340 6|6 A3.3 mouse S160-p 7172003 SSTDSYSsAASYTDS molecular association, regulation SLC4A4(INDUCES) 27382360 2 1 1 S149 and T172 are also involved in activation of SLCA4 +SHC4 SHC4 Adaptor/scaffold Q6S5L8 399694 15q21.1 human Y465-p 462716 DLFDDPCyINTQALQ molecular association, regulation SHP-2(INDUCES) 28213521 1 2 9 +KIF2B KIF2B Microtubule-binding; Motor Q8N4N8 84643 17q22 human S204-p 25247528 HLDSSKIsVLEPPQE activity, induced; intracellular localization cell cycle regulation; cytoskeletal reorganization 22535524 1 1 0 involved in the corrections of k-MT attachment errors in early mitosis, microtubule depolymerization activity +HOXB7 HOXB7 DNA-binding; Motility/polarity/chemotaxis; Transcription factor P09629 3217 17q21.32 human T203-p 465571 NKTAGPGtTGQDRAE cell differentiation, altered 11290787 1 0 0 +Rasgrf1 RASGRF1 GEF; GEF, Ras P27671 19417 9 E3.1|9 47.31 cM mouse S737-p 469604 PLAIGTSsPSRRRKL RasGEF_N protein degradation 16921254 1 2 1 controls nuclear organization in cortical neurons +AR AR DNA-binding; Nuclear receptor; Transcription factor P10275 367 Xq12 human K848-ub 7911900 RIIACKRkNPTSCSR Hormone_recep intracellular localization 35163481 4 1 0 +Bcl2l11 BIM Apoptosis O88498 64547 3q36 rat T110-p 449070 PMSCDKStQTPSPPC apoptosis, induced 12388545 1 1 0 +E2F1 E2F1 DNA-binding; Transcription factor Q01094 1869 20q11.22 human R113-me 57676508 GPARGRGrHPGKGVK protein degradation; molecular association, regulation; ubiquitination; methylation cell cycle regulation; carcinogenesis, induced; cell growth, induced; apoptosis, inhibited; transcription, inhibited TSN(INDUCES) DNA(DISRUPTS) 22327218; 24076217 2 1 0 inhibits asymmetrical methylation. Binding to TSN regulates binding of TSN to DNA +INSIG2 INSIG2 Endoplasmic reticulum; Membrane protein, integral; Membrane protein, multi-pass; Transcription, coactivator/corepressor Q9Y5U4 51141 2q14.1-q14.2 human K100-ub 486341 RHLGEPHkFKREWSS INSIG protein degradation 16549805 1 0 0 INSIG1 is degraded more rapidly than INSIG2 which controlled by serine residues flanking the ubiquitination sites in both proteins. +TOP1 TOP1 EC 5.99.1.2; Isomerase; Nucleolus; Oncoprotein P11387 7150 20q12 human K436-sm 40724401 LNPSSRIkGEKDWQK Topoisom_I molecular association, regulation; enzymatic activity, inhibited POLR2A(INDUCES) 25851487 1 0 0 recruitment of mRNA processing factors to transcriptionally active chromatin preventing R-loops +Ppargc1a PGC-1 alpha Nuclear receptor co-regulator; Transcription, coactivator/corepressor O70343 19017 5|5 C1 mouse S284-p 15422185 KTIERTLsVELSGTA protein stabilization 23201126 1 0 2 +Pxn PXN Adaptor/scaffold; Cell adhesion; Cytoskeletal; Motility/polarity/chemotaxis Q66H76 360820 12q16 rat S130-p 450228 KQKSAEPsPTVMSSS Paxillin intracellular localization 16537926 5 25 4 necessary for formation of NGF-induced neurite extensions +Ermn ERMN Q5RJL0 rat S278-p 3215796 QRIDEFEsMMHL___ Ermin molecular association, regulation; intracellular localization; activity, inhibited cytoskeletal reorganization ACTB(DISRUPTS) 20610382 1 38 27 +EIF6 EIF6 Nucleolus; Translation; Translation initiation P56537 3692 20q11.22 human S243-p 3193267 MRDSLIDsLT_____ intracellular localization translation, altered 32703900 1 15 9 +MAP2K6 MKK6 iso2 EC 2.7.12.2; KINASE; Kinase, protein; Protein kinase, STE; Protein kinase, dual-specificity (non-receptor) P52564-2 5608 17q24.3 human T155-p 448195 LVDSVAKtIDAGCKP Pkinase enzymatic activity, induced 8621675 4 2 2 +PIK3AP1 BCAP Adaptor/scaffold Q9DDT2 374268 chicken Y199-p 450043 CGVQTTVyIIMKCRL DBB molecular association, regulation PIK3R1(INDUCES) 11163197 1 0 0 +MDM2 MDM2 EC 6.3.2.-; EC 6.3.2.19; Inhibitor; Ligase; NEDDYLATION LIGASE; Neddylation Ligase; Nucleolus; Oncoprotein; UBIQUITIN LIGASE; Ubiquitin conjugating system; Ubiquitin ligase Q00987 4193 12q15 human S166-p 448130 SSRRRAIsETEENSD activity, induced; protein degradation; protein stabilization; molecular association, regulation; ubiquitination; intracellular localization; enzymatic activity, induced cell cycle regulation; carcinogenesis, induced; apoptosis, altered; apoptosis, induced; transcription, induced; signaling pathway regulation; translation, altered; cell growth, induced; apoptosis, inhibited; translation, induced p53(INDUCES); p300(INDUCES); ARF1(INDUCES) RNA(INDUCES) 11504915; 11715018; 15024078; 15169778; 15688025; 18467333; 19008219; 20657550; 22525275; 26636645; 27264869; 27617579; 32453417; 34992144; 36149602; 37179400 50 19 5 +Amelx AMELX iso1 Secreted; Secreted, signal peptide P63277-1 11704 X F5|X 78.95 cM mouse S32-p 34729901 SPGYINLsYEVLTPL Amelogenin protein conformation 25071599 4 1 0 +DDX5 DDX5 EC 3.6.4.13; Helicase; Nuclear receptor co-regulator; Nucleolus; RNA splicing; RNA-binding; Spliceosome P17844 1655 17q23.3 human K32-ac 466258 RAGPLSGkKFGNPGE protein stabilization; molecular association, regulation carcinogenesis, induced; transcription, induced HDAC1(INDUCES); HDAC2(INDUCES) 20663877 1 4 84 +Adora3 ADORA3 GPCR, family 1; Membrane protein, integral; Membrane protein, multi-pass; Receptor, GPCR P28647 25370 2q34 rat T307-p 450328 RACRLCQtSDSLDSN receptor desensitization, altered 10692494 1 0 0 +H3c1 H3 DNA-binding P68433 360198 13|13 A3.1 mouse K9-ac 463820 RTKQTARkSTGGKAP Histone protein degradation; molecular association, regulation; acetylation; intracellular localization cell cycle regulation; endocytosis, altered; transcription, induced; transcription, altered; DNA repair, induced; chromatin organization, altered; cell differentiation, induced; cell adhesion, altered; transcription, inhibited p300(INDUCES); PCAF(INDUCES); GCN5(INDUCES) DNA(INDUCES) 10899125; 16687444; 17823087; 18039862; 18243098; 18662547; 18927235; 19109180; 19264835; 19707598; 19859561; 19922872; 19965984; 20067909; 20129940; 20543957; 20561915; 20574709; 20710121; 20935159; 22237151; 23341587; 23405071; 25772242; 32265492; 33087562; 33195484; 34914791 230 26 341 anacarddic acid (AA) and the JNK inhibitor SP600125 inhibit transcription of cardiac hypertrophy-related genes, attenuating cardiomyocyte hypertrophy ; offspring born to mice exposed to human relevant arsenic concentrations ; transcription maintained at normal levels; axon guidance; Histone acetylation induces AKT signaling at AKT promoter; p-JNK directly interacted with HATs inhibiting H3K9ac; modulates circadian rhythms; MYST3 inhibits cellular senescence; SIRT6 inhibits acetylated H3 and AKT signaling +G6PD G6PD Carbohydrate Metabolism - pentose phosphate pathway; Cell development/differentiation; EC 1.1.1.49; Other Amino Acids Metabolism - glutathione; Oxidoreductase P11413 2539 Xq28 human Y322-p 4114824 EGEATKGyLDDPTVP G6PD_C enzymatic activity, induced carcinogenesis, inhibited; cell growth, inhibited 37491277 1 2 5 +TUBGCP6 GCP6 Cytoskeletal; Motility/polarity/chemotaxis Q96RT7 85378 22q13.33 human S1397-p 472628 EDTAAQSsPGRGEEA cytoskeletal reorganization 17182859 1 1 1 role in the attachment of microtubule-organizing centers (MTOC) to IFs in epithelial cells +DLC1 DLC1 GAP; GAP, Rac/Rho; Tumor suppressor Q96QB1 10395 8p22 human S764-p 18260533 SPVTRTRsLSACNKR molecular association, regulation carcinogenesis, altered; cell motility, altered; cell growth, altered 14-3-3 beta(INDUCES); 14-3-3 theta(INDUCES); 14-3-3 eta(INDUCES) 32606003 1 2 0 +RUNX2 AML3 DNA-binding; Transcription factor Q13950 860 6p21.1 human T200-p 27728400 RGKSFTLtITVFTNP Runt molecular association, regulation transcription, induced DNA(INDUCES) 23389849 1 0 0 induction of MMP3 and MMP9 transcription, invasion of breast cancer cells +BRCA1 BRCA1 EC 6.3.2.-; Nuclear receptor co-regulator; Transcription, coactivator/corepressor; Tumor suppressor; UBIQUITIN LIGASE; Ubiquitin conjugating system; Ubiquitin ligase P38398 672 17q21.31 human S632-p 478486 LVVSRNLsPPNCTEL transcription, altered 17334399 1 3 0 inhibits transcription by interfering with DNA-binding ability of BRCA1 +HDAC1 HDAC1 DEACETYLASE; Deacetylase; EC 3.5.1.98; Hydrolase; Nuclear receptor co-regulator Q13547 3065 1p35.2-p35.1 human K438-ac 4219806 RKNSSNFkKAKRVKT enzymatic activity, inhibited transcription, inhibited 16762839 1 0 2 +DTD1 DTD1 DNA replication; EC 3.1.-.-; Hydrolase Q8TEA8 92675 20p11.23 human S204-p 476435 SGAEGDVsSEREP__ molecular association, regulation cell cycle regulation; cell growth, induced MCM7(INDUCES); MCM3(DISRUPTS) 25258324 1 15 0 decreases DTD1 incorporation into HMW, supports DNA replication initiation +Lat LAT Adaptor/scaffold; Membrane protein, integral O54957 16797 7|7 F3 mouse Y235-p 448006 DGEEAPDyENLQELN LAT phosphorylation 15470052 17 3 72 regulates exocytosis and cytokine secretion +Sox11 SOX11 DNA-binding; Transcription factor Q7M6Y2 20666 12|12 A2 mouse S133-p 1290433400 TDPAAKPsAGQSPDK transcription, induced 30385877 1 1 0 regulates neuronal/ dendritic morphogenesis +DVL2 DVL2 Adaptor/scaffold; Motility/polarity/chemotaxis O14641 1856 17p13.1 human T224-p 25538000 MSRFSSStEQSSASR Dishevelled molecular association, regulation; intracellular localization transcription, induced; cytoskeletal reorganization PLK1(INDUCES) 22609948; 32888647 2 1 0 +XRCC1 XRCC1 DNA repair, damage P18887 7515 19q13.31 human S525-p 451451 STDENTDsEEHQEPP molecular association, regulation; intracellular localization PARP1(DISRUPTS); Pnk1(INDUCES) 15066279; 25477519 2 3 3 +Cfl1 Cofilin-1 Cytoskeletal; Motility/polarity/chemotaxis; Nuclear receptor co-regulator P45592 29271 1q43 rat S3-p 448444 _____MAsGVAVSDG intracellular localization; activity, inhibited cell motility, altered; cytoskeletal reorganization 11086013; 11418599; 18171679; 24914207; 34015497; 35809641; 9655397 97 69 3 +Flcn FLCN Tumor suppressor Q76JQ2 303185 10q22 rat S62-p 3206874 SSRVRAHsPAEGAST molecular association, regulation AMPKA1(INDUCES) 19695222; 19914239 5 56 5 +Bdkrb2 BKR2 GPCR, family 1; Membrane protein, integral; Membrane protein, multi-pass; Receptor, GPCR P25023 25245 6q32 rat Y161-p 452084 MLVSIDRyLALVKTM 7tm_1 activity, induced; receptor desensitization, altered 9837936 2 2 0 +Rps6kb1 p70S6K EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, AGC; Protein kinase, Ser/Thr (non-receptor); Translation P67999 83840 10q26 rat T252-p 448606 HDGTVTHtFCGTIEY Pkinase enzymatic activity, induced 7777579; 9632736 36 2 17 +Pdpk1 PDK1 EC 2.7.11.1; KINASE; Kinase, protein; Nuclear receptor co-regulator; Protein kinase, AGC; Protein kinase, Ser/Thr (non-receptor) Q9Z2A0 18607 17|17 A3.3 mouse T516-p 450132 PEAKNFKtFFVHTPN PH_3 enzymatic activity, induced 11877406 5 4 0 +TGFBR2 TGFBR2 EC 2.7.11.30; KINASE; Kinase, protein; Membrane protein, integral; Oncoprotein; Protein kinase, Ser/Thr (receptor); Protein kinase, TKL P37173 7048 3p24.1 human Y336-p 2869603 AKGNLQEyLTRHVIS PK_Tyr_Ser-Thr activity, induced; enzymatic activity, induced; phosphorylation transcription, altered; signaling pathway regulation 24983314; 9169454 3 0 0 +INSR INSR EC 2.7.10.1; KINASE; Kinase, protein; Membrane protein, integral; Protein kinase, TK; Protein kinase, tyrosine (receptor) P06213 3643 19p13.2 human S1064-p 451563 KTVNESAsLRERIEF PK_Tyr_Ser-Thr phosphorylation 10819237 3 1 1 alanine mutations of S1033, S1062, and S1064 increases tyrosine autophosphorylation of InsR +PAK1 PAK1 EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, STE; Protein kinase, Ser/Thr (non-receptor) Q13153 5058 11q13.5-q14.1 human S21-p 448174 APPMRNTsTMIGAGS intracellular localization cytoskeletal reorganization 16490784 3 0 10 No effect on VASP binding. S21A Pak1 mutation effects localization of Pak1 and cell polarization. +Bid BID Apoptosis; Mitochondrial P70444 12122 6 F1|6 57.02 cM mouse S61-p 448404 DELQTDGsQASRSFN BID protein stabilization cell cycle regulation; apoptosis, inhibited 11583622; 16122426 3 0 0 +FANCD2 FANCD2 DNA repair, damage Q9BXW9 2177 3p25.3 human S1401-p 38488713 LQGEEIKsQNSQEST FancD2 activity, induced; molecular association, regulation; ubiquitination; intracellular localization signaling pathway regulation DNA(INDUCES) 37392383 2 4 3 regulates the FA pathway +SLA SLAP Adaptor/scaffold Q13239 6503 8q24.22 human Y120-p 15570321 SETKKGFySLSVRHR SH2 activity, inhibited 24284075 1 0 1 oncogenic c-Kit bypasses the normal cellular negative feedback control +DEPTOR DEPTOR Apoptosis Q8TB45 64798 8q24.12 human S287-p 4723848 SMSSCGSsGYFSSSP protein degradation; molecular association, regulation; ubiquitination carcinogenesis, induced; apoptosis, inhibited; signaling pathway regulation BTRC(INDUCES); mTOR(DISRUPTS); FBW1B(INDUCES) 19446321; 22017876; 22017877 4 3 0 PI3K-Akt signaling +EIF2AK3 PERK EC 2.7.11.1; KINASE; Kinase, protein; Membrane protein, integral; Protein kinase, Other; Protein kinase, Ser/Thr (non-receptor); Translation Q9NZJ5 9451 2p11.2 human Y619-p 1256400 NKVDDCNyAIKRIRL Pkinase enzymatic activity, induced signaling pathway regulation 25113558 4 1 0 STAT3 activation, PERK-JAK1-STAT3 pathway +Porcn PORCN EC 2.3.1.-; Endoplasmic reticulum; Membrane protein, integral; Membrane protein, multi-pass; Transferase Q9JJJ7 53627 X A1.1|X 3.7 cM mouse S378-p 1869465804 ILSACILsKRCLPDC receptor internalization, induced signaling pathway regulation 31611414 1 0 0 +SMAD2 SMAD2 DNA-binding; Transcription factor Q15796 4087 18q21.1 human T8-p 448792 MSSILPFtPPVVKRL activity, induced; protein stabilization; molecular association, regulation transcription, induced SMAD4(INDUCES) 12193595 3 29 0 +CCDC6 CCDC6 Apoptosis; Cytoskeletal; Oncoprotein Q16204 8030 10q21.2 human K74-sm 27992504 QQENKVLkIELETYK DUF2046 intracellular localization transcription, induced; signaling pathway regulation 23145146 1 0 0 cyclic AMP activity +KAT6A MYST3 ACETYLTRANSFERASE; Acetyltransferase; EC 2.3.1.48; Nucleolus; Oncoprotein Q92794 7994 8p11.21 human T369-p 19008950 RGRKRKItLSSQSAS molecular association, regulation; acetylation transcription, inhibited PML(DISRUPTS) 23431171 1 0 0 decreases acetylation +STK11 LKB1 Autophagy; EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, CAMK; Protein kinase, Ser/Thr (non-receptor); Tumor suppressor Q15831 6794 19p13.3 human S428-p 448147 SSKIRRLsACKQQ__ molecular association, regulation; intracellular localization; phosphorylation; enzymatic activity, induced cell cycle regulation; carcinogenesis, induced; carcinogenesis, inhibited; cell motility, induced; signaling pathway regulation; cell growth, altered Exportin-1(INDUCES); STRAD(INDUCES) 16407220; 18321849; 19414597; 34921839; 35835853 33 2 3 +VAV3 VAV3 Actin-binding; Adaptor/scaffold; GEF; GEF, Rac/Rho; Motility/polarity/chemotaxis; Nuclear receptor co-regulator Q9UKW4 10451 1p13.3 human Y160-p 1869344401 VEDEEDLyDCVYGED activity, induced 32561640 1 0 0 VAV3 signaling activity +RPS6KA6 RSK4 EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, AGC; Protein kinase, Ser/Thr (non-receptor) Q9UK32 27330 Xq21.1 human S389-p 457602 HQLFKGFsFVATSIA Pkinase_C enzymatic activity, induced 15632195 1 6 6 +Rps6kb1 p70S6K EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, AGC; Protein kinase, Ser/Thr (non-receptor); Translation Q8BSK8 72508 11|11 C mouse S447-p 448357 GSPRTPVsPVKFSPG molecular association, regulation; enzymatic activity, induced cell differentiation, altered DEDD(INDUCES) 10846175; 19106089 102 54 247 +Tlr9 TLR9 Membrane protein, integral; Receptor, misc. Q9EQU3 81897 9|9 F1 mouse Y870-p 1192504600 RSAQTLPyDAFVVFD TIR protein stabilization; intracellular localization autophagy, inhibited 30024926 1 0 0 regulates receptor maturation +HSP90AA1 HSP90A Chaperone; Heat shock protein P07900 3320 14q32.31 human S726-p 3180213 LEGDDDTsRMEEVD_ protein stabilization; molecular association, regulation carcinogenesis, induced; cell growth, induced HOPX(INDUCES); CHIP(DISRUPTS) 22824801 1 0 0 cell proliferation increased +Smad3 SMAD3 DNA-binding; Nuclear receptor co-regulator; Transcription factor Q8BUN5 17127 9|9 C mouse S213-p 451180 NLSPNPMsPAHNNLD carcinogenesis, inhibited; cell differentiation, induced; transcription, altered 36241625 13 0 0 regulates Th9 differentiation +Xbp1 XBP1 iso2 DNA-binding; Transcription factor O35426-2 22433 mouse K297-sm 13875700 PEFIVSVkKEPLEDD transcription, inhibited 20408817 1 0 0 +HSF2 HSF2 DNA-binding Q03933 3298 6q22.31 human K82-sm 2535908 HIDSGIVkQERDGPV HSF_DNA-bind molecular association, regulation DNA(DISRUPTS) 16428449; 19017645 3 2 0 +DNMT1 DNMT1 Amino Acid Metabolism - cysteine and methionine; Cell development/differentiation; EC 2.1.1.37; METHYLTRANSFERASE; Methyltransferase; Methyltransferase, DNA; Transcription regulation P26358 1786 19p13.2 human K142-m1 17772901 PRTPRRSkSDGEAKP protein degradation; molecular association, regulation; ubiquitination; phosphorylation PHF20L1(INDUCES) 21151116; 21239472; 24492612 4 1 0 +Relb RELB Transcription factor Q04863 19698 7 A3|7 9.93 cM mouse T84-p 1869360403 AAPPPPAtPSWSCTL RelB_leu_zip protein degradation 11781828 1 0 0 +Relb RELB Transcription factor Q04863 19698 7 A3|7 9.93 cM mouse S451-p 36392502 DFFPASIsLPGLEPP RelB_transactiv molecular association, regulation transcription, inhibited IkB-alpha(DISRUPTS) DNA(INDUCES) 30957303 2 0 0 inhibits removal of RelB from cytokine promoters by IkB-alpha +Pebp1 RKIP Lipid-binding; Protein kinase, regulatory subunit P70296 23980 5 F|5 56.88 cM mouse S109-p 59070500 VLSDYVGsGPPSGTG PBP molecular association, regulation TBK1(INDUCES) 28411188 2 0 0 +YTHDF2 YTHDF2 RNA processing; RNA-binding Q9Y5A9 51441 1p35.3 human K571-sm 1881250300 QEEEESVkKERQGRG molecular association, regulation carcinogenesis, induced; transcription, induced RNA(INDUCES) 33577677 1 0 0 increases its binding af?nity of m6 A-modi?ed mRNAs +VIM Vimentin Cytoskeletal; Motility/polarity/chemotaxis P08670 7431 10p13 human K439-sm 1877412900 PLVDTHSkRTLLIKT cell motility, induced; cytoskeletal reorganization; cell growth, altered 32047143 1 1 0 increases its solubility +ATXN10 ataxin-10 Cell development/differentiation Q9UBB4 25814 22q13.31 human T82-p 21514208 ASSLQLItECFRCLR protein degradation; ubiquitination cell cycle regulation 21857149 2 1 0 required for cytokinesis +Stat5a STAT5A DNA-binding; Motility/polarity/chemotaxis; Oncoprotein; Transcription factor P42230 20850 11 D|11 63.77 cM mouse Y694-p 447767 LAKAVDGyVKPQIKQ activity, induced carcinogenesis, induced; carcinogenesis, inhibited; cell growth, induced; transcription, induced; signaling pathway regulation; transcription, altered; cell growth, altered DNA(INDUCES) 10744710; 11413148; 12091337; 12529425; 20028972; 25143441; 26710253; 32122995; 34535769; 36356831; 36773294 156 50 2180 induces IL-2 signaling +PDE4D PDE4D iso4 EC 3.1.4.53; Nucleotide Metabolism - purine; Phosphodiesterase Q08499-4 5144 5q11.2-q12.1 human S490-p 451090 YQSTIPQsPSPAPDD enzymatic activity, induced 10828059 7 3 0 +TH TH Amino Acid Metabolism - tyrosine; EC 1.14.16.2; Endoplasmic reticulum; Mitochondrial; Oxidoreductase; Vesicle P07101 7054 11p15.5 human S40-p 1876194200 GQGAPGPsLTGSPWP TOH_N molecular association, regulation; protein conformation; enzymatic activity, induced Other(DISRUPTS) 35013193 1 0 0 inhibits binding to Dopamine +YAP1 YAP1 iso3 Oncoprotein; Transcription, coactivator/corepressor P46937-3 10413 11q22.1 human Y357-p 473004 SGLSMSSySVPRTPD activity, induced; molecular association, regulation; intracellular localization carcinogenesis, induced; carcinogenesis, inhibited; apoptosis, induced; cell growth, induced; transcription, induced TEAD1(INDUCES); p73(INDUCES) 27013234; 34697383; 35015027 23 3 4 +Trpv2 TRPV2 Channel, cation; Membrane protein, integral; Membrane protein, multi-pass Q9WUD2 29465 10q23 rat Y525-p 2527084 GFQHTGIySVMIQKV Ion_trans activity, induced; protein stabilization endocytosis, induced 35686730 1 1 0 +KAT7 MYST2 ACETYLTRANSFERASE; Acetyltransferase; EC 2.3.1.48; Nuclear receptor co-regulator; Transcription, coactivator/corepressor O95251 11143 17q21.33 human S57-p 460899 SQSSQDSsPVRNLQS cell cycle regulation; carcinogenesis, induced; apoptosis, inhibited; transcription, induced 18250300; 23188630 2 55 52 +KHSRP KHSRP RNA-binding Q92945 8570 19p13.3 human S274-p 482097 MILIQDGsQNTNVDK KH_1 activity, induced; molecular association, regulation 21329876 1 15 15 binds to and functions in pri-miRNA processing +SMAD2 SMAD2 DNA-binding; Transcription factor Q15796 4087 18q21.1 human K19-ac 470076 VKRLLGWkKSAGGSG molecular association, regulation; intracellular localization; protein conformation cell cycle regulation; cell growth, inhibited; transcription, induced; signaling pathway regulation DNA(INDUCES) 17074756; 17478422; 29187201 3 1 4 +RUNX1/RUNX1T1 fusion AML1-ETO A0A7S8LV65 human K58-ac 1880757300 AGAALAGkLRSGDRS transcription, induced 31699991 1 1 0 +ABI1 Abi-1 Adaptor/scaffold; Motility/polarity/chemotaxis Q8IZP0 10006 10p12.1 human T394-p 12626406 ENIADSPtPPPPPPP molecular association, regulation cell motility, altered; cytoskeletal reorganization 21419341 1 1 0 regulates WRC (WAVE2 regulatory complex) interaction with Arp2/3 and lamellipodial protrusion +Dlc1 DLC1 GAP; GAP, Rac/Rho; Tumor suppressor Q9R0Z9 50768 8 A4|8 23.05 cM mouse Y452-p 1869008602 NVPGSILySSSGELA molecular association, regulation carcinogenesis, induced; cell growth, induced; apoptosis, inhibited tensin 1 iso1(DISRUPTS) 31308216 1 1 0 Rho-GAP activity +Dok3 DOK3 Adaptor/scaffold Q9QZK7 27261 13|13 B1 mouse Y325-p 454685 EGPASGLyASVCKQT molecular association, regulation CSK(INDUCES); SHIP(INDUCES) 14993273 1 2 15 +NUP153 NUP153 Nuclear export; Nucleoporin P49790 9972 6p22.3 human S529-p 452707 SPMFKFSsPIVKSTE Nup153 molecular association, regulation KPNB1(DISRUPTS) 19767751 1 18 0 +Cers2 LASS2 DNA-binding; Membrane protein, integral; Membrane protein, multi-pass; Transferase Q924Z4 76893 3|3 F2.1 mouse S341-p 470692 KLIEDERsDREETES enzymatic activity, induced 26887952 1 47 217 +NFKB2 NFkB-p100 DNA-binding; Oncoprotein; Transcription factor Q00653 4791 10q24.32 human K298-sm 3055608 TPPYHKMkIERPVTV RHD_dimer protein processing; phosphorylation signaling pathway regulation 18617892 1 0 0 activation of alternative NF-kB pathway +YAP1 YAP1 Oncoprotein; Transcription, coactivator/corepressor P46937 10413 11q22.1 human S436-p 1874499600 INQSTLPsQQNRFPD activity, induced; protein stabilization; molecular association, regulation; intracellular localization carcinogenesis, induced; cell motility, induced; cell growth, induced; transcription, induced TEAD1(INDUCES); TEAD4(INDUCES); TEAD3(INDUCES); TEAD2(INDUCES) 34343821 1 0 0 +Lepr LEPR Membrane protein, integral; Receptor, cytokine Q62959 rat Y985-p 448435 QSQPSVKyATLVSNV activity, induced; molecular association, regulation neural plasticity ARHGEF7(INDUCES) 34006608 16 0 0 Interaction leads to developmental increase in GABAergic synaptogenesis +Kcne1 KCNE1 Channel, potassium; Membrane protein, integral P15383 25471 11q11 rat S103-p 10349700 FQARVLEsFRACYVI ISK_Channel activity, inhibited 1553557 5 0 0 +EGFR EGFR EC 2.7.10.1; KINASE; Kinase, protein; Membrane protein, integral; Oncoprotein; Protein kinase, TK; Protein kinase, tyrosine (receptor) P00533 1956 7p11.2 human K745-m1 63106400 VKIPVAIkELREATS PK_Tyr_Ser-Thr molecular association, regulation; phosphorylation; enzymatic activity, induced cell cycle regulation; carcinogenesis, induced; signaling pathway regulation PCNA(INDUCES) 28102297 1 1 0 inhibits EGFR?s downstream signaling pathway involving RAS, RAF, MEK and ERK; activates phosphorylation of itself at other sites +OCLN occludin Cell adhesion; Membrane protein, integral; Membrane protein, multi-pass; Motility/polarity/chemotaxis A2VE81 512405 cow S490-p 6094300 RLKQVKGsADYKSKR Occludin_ELL intracellular localization cell motility, induced; cell growth, induced 27423695 11 1 0 VEGF-induced tube formation, VEGF-induced tube formation, localizes to centrosomes, retinal neovascularization +ZBTB16 PLZF C2H2-type zinc finger protein; DNA-binding; Oncoprotein; Transcription, coactivator/corepressor Q05516 7704 11q23.2 human K650-ac 50455004 SSMQKHMkGHKPEEI molecular association, regulation; acetylation; intracellular localization chromatin organization, altered; transcription, inhibited DNA(INDUCES) 26405459 1 0 0 induces histone acetylation and DNA hypermethylation +ZNRF2 ZNRF2 EC 6.3.2.-; EC 6.3.2.19; Ligase; UBIQUITIN LIGASE; Ubiquitin conjugating system; Ubiquitin ligase Q8NHG8 223082 7p14.3 human S145-p 4742836 GPRLVIGsLPAHLSP intracellular localization 27244671 1 28 10 +RELA NFkB-p65 DNA-binding; Nuclear receptor co-regulator; Transcription factor Q04206 5970 11q13.1 human K314-ac 1985900 ETFKSIMkKSPFSGP molecular association, regulation; intracellular localization carcinogenesis, induced; cell motility, induced; cell growth, induced; transcription, induced; transcription, inhibited; transcription, altered DNA(DISRUPTS) 18263619; 20064247; 23087373; 28167529; 31939185; 34626802 7 1 0 recruited to the IL-8 promoter +E2F1 E2F1 DNA-binding; Transcription factor Q01094 1869 20q11.22 human K266-sm 1876998410 EQMVMVIkAPPETQL E2F_CC-MB cell cycle regulation; transcription, inhibited 32541040 1 1 0 +NPR1 ANPA EC 4.6.1.2; Guanylyl cyclase; KINASE; Kinase, protein; Lyase; Membrane protein, integral; Nucleotide Metabolism - purine; Protein kinase, RGC; Protein kinase, dual-specificity (receptor); Receptor, misc. P16066 4881 1q21.3 human S538-p 447515 LTLSGRGsNYGSLLT activity, induced; enzymatic activity, induced 28416574; 9528788 3 2 0 +GABRB2 GABRB2 Channel, chloride; Channel, ligand-gated; Membrane protein, integral; Membrane protein, multi-pass; Transporter; Transporter, ion channel P47870 2561 5q34 human T389-p 10769102 LSPTRRTtNYDFSLY Neur_chan_memb activity, inhibited 19763268 1 0 0 channel current run-down is reduced in T389A mutant receptor; i.e., phosphorylation may contribute to channel inhibition +Btk Btk EC 2.7.10.2; KINASE; Kinase, protein; Protein kinase, TK; Protein kinase, tyrosine (non-receptor) P35991 12229 X E3|X 56.18 cM mouse Y375-p 457681 GLISRLKyPVSKQNK not reported 16291652 1 3 22 mutation of site in transfection assays or knock-in mice had no significant effect on biological function. +Kcnb1 Kv2.1 Channel, cation; Channel, ligand-gated; Channel, potassium; Membrane protein, integral; Membrane protein, multi-pass P15387 25736 3q42 rat S457-p 473558 MKDAFARsIEMMDIV activity, inhibited 16917065 4 6 0 +GTF2I GTF2I iso2 DNA-binding; Transcription, coactivator/corepressor P78347-2 2969 7q11.23 human S627-p 452349 INTKALQsPKRPRSP transcription, altered 10648599 1 11 5 +PPP1R1A PPP1R1A Inhibitor; Protein phosphatase, regulatory subunit Q13522 5502 12q13.2 human S67-p 447758 LKSTLAMsPRQRKKM DARPP-32 phosphorylation; enzymatic activity, induced cytoskeletal reorganization 10811908; 17416610 12 14 2 decreased contractility, and decreased PLB phosphorylation in PPP1R1A S67D and T75D mutants +NFAT5 NFAT5 Transcription factor O94916 10725 16q22.1 human S155-p 2715402 PEDLLDNsRMSCQDE intracellular localization 18411282; 21209322 3 4 2 +NELFCD NELFCD iso4 Adaptor/scaffold Q8IXH7-4 51497 20q13.32 human Y6-p 23003806 __MDEDYyGSAAEWG TH1 protein degradation; molecular association, regulation; phosphorylation cell motility, induced; signaling pathway regulation PAK1(DISRUPTS); ARAF(DISRUPTS) 22238675 1 0 0 MAPK/ERK signaling, enhanced ERK phosphorylation +Krt17 K17 Cytoskeletal Q9QWL7 16667 11 D|11 63.44 cM mouse S44-p 464291 AGSCRLGsASGLGSA molecular association, regulation cell cycle regulation 14-3-3 sigma(NOT_REPORTED) 16710422 2 1 0 Mutation of T8 and S43 (to alanine) causes reduced phosphorylation of Akt S473 and p70S6K T389. +Ppargc1a PGC-1 alpha Nuclear receptor co-regulator; Transcription, coactivator/corepressor Q9QYK2 rat S569-p 2045307 RMRSRSRsFSRHRSC acetylation; activity, inhibited transcription, altered 19940161 4 0 0 +UBA52-RPS27A-UBB-UBC ubiquitin Ubiquitin-like modifier P62989 rat S65-p 9765472 DYNIQKEsTLHLVLR ubiquitin molecular association, regulation autophagy, induced RHOT1(INDUCES) 30504269 27 17 0 mitochondrial depolarization +BAD BAD Apoptosis Q92934 572 11q13.1 human R94-m2 51576300 GEEPSPFrGRSRSAP Bcl-2_BAD molecular association, regulation; phosphorylation 14-3-3 beta(DISRUPTS) 21444773 1 0 0 methylation of BAD inhibits S99 phosphorylation by Akt, and binding to 14-3-3-beta +Crtc1 TORC1 Transcription factor Q68ED7 382056 8|8 B3.3 mouse S167-p 18255800 MTPSQAEsFTGGSQD TORC_M intracellular localization transcription, induced 28076781 2 0 0 nuclear import and retention +Rims1 RIMS1 iso7 Adaptor/scaffold; Vesicle Q99NE5-7 116837 1|1 A5 mouse S413-p 450481 ARHERRHsDVALPHT molecular association, regulation 14-3-3 epsilon(INDUCES) 18799741 4 6 0 +FOXO3 FOXO3A Autophagy; DNA-binding; Oncoprotein; Transcription factor O43524 2309 6q21 human K569-ac 460597 SSSLGSAkHQQQSPV protein stabilization; molecular association, regulation; ubiquitination apoptosis, induced; transcription, induced JNK1(INDUCES); SKP2(DISRUPTS) 21841822; 27669435 3 0 0 +Mapt Tau ACETYLTRANSFERASE; Acetyltransferase; Cytoskeletal P19332 29477 10q32.1 rat T516-p 447933 SSPGSPGtPGSRSRT molecular association, regulation; protein conformation PPP1CC(INDUCES) 28784767; 36859689 142 27 26 +TFB2M TFB2M EC 2.1.1.-; METHYLTRANSFERASE; Methyltransferase; Transcription, coactivator/corepressor Q9H5Q4 64216 1q44 human T184-p 25756119 GIEAVPWtADIPLKV RrnaAD molecular association, regulation transcription, inhibited POLRMT(DISRUPTS) DNA(DISRUPTS) 32505352 1 0 1 +BLNK BLNK Adaptor/scaffold Q8WV28 29760 10q24.1 human T152-p 23303201 EKARLTStLPALTAL molecular association, regulation; protein conformation 14-3-3 sigma(INDUCES); 14-3-3 zeta(INDUCES); 14-3-3 gamma(INDUCES) 33176192 2 0 0 +FERMT2 kindlin-2 Cytoskeletal; Motility/polarity/chemotaxis Q96AC1 10979 14q22.1 human S177-p 4760248 LITPGSGsIYSSPGL protein degradation; molecular association, regulation; ubiquitination cell cycle regulation; cell growth, induced; apoptosis, inhibited; cytoskeletal reorganization; cell adhesion, inhibited CUL9(INDUCES) 35469017 1 3 1 +RORA RORA iso4 DNA-binding; Nuclear receptor P35398-4 6095 15q22.2 human T128-p 482887 PGEAEPLtPTYNISA activity, inhibited transcription, inhibited DNA(DISRUPTS) 17512500 1 0 0 +Nrip1 RIP140 Nuclear receptor co-regulator; Transcription, coactivator/corepressor Q8CBD1 268903 16|16 C3.1 mouse K482-ac 459038 KIPGVDIkEDQDTST NRIP1_repr_2 intracellular localization transcription, inhibited 15879431 0 2 0 +Cd79b Ig-beta Membrane protein, integral; Receptor, misc. P15530 15985 11 E1|11 68.89 cM mouse Y195-p 459286 GMEEDHTyEGLNIDQ ITAM phosphorylation 9531288 2 1 5 +CTNNB1 CTNNB1 Actin-binding; Cell adhesion; Motility/polarity/chemotaxis; Nuclear receptor co-regulator; Oncoprotein; Transcription factor XP_008258482 100125985 rabbit S33-p 447487 QQQSYLDsGIHSGAT protein degradation cell differentiation, inhibited 34094857 112 3 2 +Mcl1 MCL1 Apoptosis; Channel, misc.; Inhibitor; Membrane protein, integral; Mitochondrial P97287 17210 3 F2.1|3 40.74 cM mouse T144-p 455375 ADGSLPStPPPPEEE protein stabilization; molecular association, regulation PIN1(INDUCES) 17670986 20 17 8 +Flt3 FLT3 EC 2.7.10.1; KINASE; Kinase, protein; Membrane protein, integral; Oncoprotein; Protein kinase, TK; Protein kinase, tyrosine (receptor) Q00342 14255 5 86.88 cM|5 G3 mouse Y922-p 456470 FYATEGIyFVMQSCW PK_Tyr_Ser-Thr protein stabilization; enzymatic activity, induced 16091740 1 0 0 +Crtc2 TORC2 Transcription, coactivator/corepressor Q3U182 74343 3|3 F1 mouse S171-p 454622 SALNRTSsDSALHTS TORC_M protein degradation; molecular association, regulation; enzymatic activity, inhibited; intracellular localization; activity, inhibited carcinogenesis, inhibited; transcription, inhibited; signaling pathway regulation; transcription, altered 14-3-3 beta(INDUCES); COP1(NOT_REPORTED) 15454081; 16148943; 17805301; 18323454; 18626018; 19254569; 19543265; 20551288; 26342077; 29941929; 33127851 19 10 12 +WASL N-WASP Adaptor/scaffold; Motility/polarity/chemotaxis O00401 8976 7q31.32 human S485-p 3149547 RSKAIHSsDEDEDED molecular association, regulation; intracellular localization; phosphorylation cell motility, induced; cytoskeletal reorganization PAK4(INDUCES) 21898535; 29100370 3 19 1 +RARA RARA DNA-binding; Nuclear receptor; Oncoprotein; Transcription factor P10276 5914 17q21.2 human S219-p 13373501 NSSEQRVsLDIDLWD molecular association, regulation; intracellular localization; activity, inhibited transcription, inhibited RXRA(DISRUPTS) 20215566 1 0 0 +BAD BAD Apoptosis Q92934 572 11q13.1 human T137-p 1904506 PRPKSAGtATQMRQS Bcl-2_BAD activity, induced 10827191 2 0 0 +MCL1 MCL1 Apoptosis; Channel, misc.; Inhibitor; Membrane protein, integral; Mitochondrial Q07820 4170 1q21.2 human K279-ub 12107118 AFVAKHLkTINQESC Bcl-2 protein degradation 28522751 1 1 4 +CHEK2 Chk2 EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, CAMK; Protein kinase, Ser/Thr (non-receptor); Tumor suppressor O96017 11200 22q12.1 human S35-p 447550 SQGSSSQsQGISSSS molecular association, regulation; enzymatic activity, induced cell cycle regulation Chk2(INDUCES); PPP2CA(DISRUPTS) 16940182; 20160490 10 1 0 S19A mutant shows impaired dimerization and does not promote Hdmx degradation +SIRT2 SIRT2 DEACETYLASE; Deacetylase; EC 3.5.1.- Q8IXJ6 22933 19q13.2 human S372-p 482810 TSASPKKsPPPAKDE enzymatic activity, induced 17516032 2 21 1 enzymatic activity of mutant S368A/S372A (but not S386A) was reduced 44% +IRS1 IRS1 Adaptor/scaffold; Motility/polarity/chemotaxis P35568 3667 2q36.3 human S330-p 447559 SFRVRASsDGEGTMS intracellular localization 34253290 4 17 5 disassociation of IRS2 from plasma membrane to cytosol; limits PM-associated PI3K and PIP3 synthesis +TNFAIP8L2 TNFAIP8L2 Q6P589 79626 1q21.3 human S3-p 56660955 _____MEsFSSKSLA protein degradation; molecular association, regulation; ubiquitination BTRC(INDUCES) 32188758 1 1 0 +BCL2L1 Bcl-xL Apoptosis; Autophagy; Membrane protein, integral; Mitochondrial Q07817 598 20q11.21 human K87-ub 12109292 VIPMAAVkQALREAG protein degradation apoptosis, induced 31792461 1 6 3 +MZF1 MZF-1 C2H2-type zinc finger protein; DNA-binding; Transcription factor P28698 7593 19q13.43 human K23-sm 1870848902 DEGPVMVkLEDSEEE activity, induced; protein conformation; phosphorylation 30622337 1 0 0 +PEX14 PEX14 Adaptor/scaffold O75381 5195 1p36.22 human S232-p 455420 NRRQFPPsPSAPKIP molecular association, regulation; protein conformation PEX14(INDUCES) 32854114 2 20 86 +TERF1 TRF1 DNA-binding P54274 7013 8q21.11 human T271-p 60179301 VESKRTRtITSQDKP molecular association, regulation cell cycle regulation DNA(INDUCES) 27841304 1 1 0 suppress telomerase-dependent telomere lengthening, phosphorylation on T271 is necessary for formation ALT-associated PML bodies (APBs) +EIF3F eIF3-epsilon EC 3.4.19.12; Translation; Translation initiation O00303 8665 11p15.4 human S46-p 448818 PAAAPASsSDPAAAA transcription, altered 12446680 2 1 0 +FLT3 FLT3 EC 2.7.10.1; KINASE; Kinase, protein; Membrane protein, integral; Oncoprotein; Protein kinase, TK; Protein kinase, tyrosine (receptor) P36888 2322 13q12.2 human Y842-p 454872 DIMSDSNyVVRGNAR PK_Tyr_Ser-Thr protein conformation; phosphorylation apoptosis, inhibited; cell growth, altered 15345593 5 2 76 FLT3 Y842C -transfected cells show constitutive FLT3 tyrosine phosphorylation and activation +Ppara PPAR-alpha DNA-binding; Nuclear receptor; UBIQUITIN LIGASE P37230 25747 7q34 rat S142-p 457550 AYDKCDRsCKIQKKN zf-C4 activity, induced transcription, altered 16042408 1 0 0 +HSD17B4 HSD17B4 Cell development/differentiation; EC 1.1.1.n12; EC 4.2.1.107; EC 4.2.1.119; Lipid Metabolism - primary bile acid biosynthesis; Lyase; Mitochondrial; Oxidoreductase P51659 3295 5q23.1 human S318-p 7445507 NHTSRATsTATSGFA protein degradation; molecular association, regulation; ubiquitination cell growth, induced; transcription, induced SKP2(INDUCES); SPOP(DISRUPTS) 33762355 1 9 12 +Pparg PPAR-gamma iso2 DNA-binding; Nuclear receptor; Transcription factor P37238-2 19016 6 E3|6 53.41 cM mouse S16-p 12170300 WPTNFGIsSVDLSVM PPARgamma_N intracellular localization transcription, altered 20026644 1 0 0 +ATXN1 ataxin-1 Nuclear export; RNA-binding P54253 6310 6p22.3 human S775-p 449110 ATRKRRWsAPESRKL protein degradation; protein stabilization; molecular association, regulation; intracellular localization cell growth, induced; transcription, induced; cytoskeletal reorganization 14-3-3 beta(INDUCES); 14-3-3 sigma(INDUCES); U2AF2(DISRUPTS); RBM17(DISRUPTS); 14-3-3 zeta(INDUCES); 14-3-3 epsilon(INDUCES); RBM17(INDUCES) 12741986; 12757707; 17540008; 20037628; 23213356; 23719381; 24858692; 29212253; 29758256; 33709453; 34302818 19 28 3 ataxin-1 S776A mutant reduces nuclear inclusion bodies of ataxin-1 in B05 tg/+ mice.; increased the expressions of cyclin D1; proliferation of cervical cancer cells; involved in the regulation of cyclin D1 transcription +XRCC1 XRCC1 DNA repair, damage P18887 7515 19q13.31 human S518-p 451449 GEDPYAGsTDENTDS molecular association, regulation; intracellular localization PARP1(DISRUPTS); APTX(INDUCES); Pnk1(INDUCES) 15066279; 15367657; 25477519 4 5 6 +CAMK2D CAMK2D EC 2.7.11.17; KINASE; Kinase, protein; Protein kinase, CAMK; Protein kinase, Ser/Thr (non-receptor) Q13557 817 4q26 human T336-p 484560 ESTESSNtTIEDEDV enzymatic activity, altered 34391760 1 21 5 +DPYSL3 CRMP-4 Hydrolase Q14195 1809 5q32 human K374-sm 1881371306 DKAVATGkMDENQFV molecular association, regulation cell growth, induced CACNA1C(DISRUPTS) 34645092 1 0 0 deSUMOylation of CRMP4 further promotes the neurite growth of cortical neurons, deSUMOylation of CRMP4 promotes thermal pain sensitivity in rats. +FANCD2 FANCD2 DNA repair, damage Q9BXW9 2177 3p25.3 human S592-p 453230 MAADRSEsPSLTQER FancD2 ubiquitination cell cycle regulation; chromatin organization, altered; cell growth, induced 34096775 1 23 6 induces monoubiquitination +PDE3A PDE3A EC 3.1.4.17; Membrane protein, integral; Membrane protein, multi-pass; Nucleotide Metabolism - purine; Phosphodiesterase Q14432 5139 12p12.2 human S438-p 456984 PGLLRRVsSTWTTTT enzymatic activity, induced cell growth, induced 25961942 4 6 9 +MARK1 MARK1 EC 2.7.11.1; EC 2.7.11.26; KINASE; Kinase, protein; Protein kinase, CAMK; Protein kinase, Ser/Thr (non-receptor) Q9P0L2 4139 1q41 human K783-ub 22247227 SGTSIAFkNIASKIA KA1 protein stabilization transcription, induced 28969054 1 4 0 +SLAMF1 SLAM Membrane protein, integral; Receptor, misc. Q13291 6504 1q23.3 human Y327-p 447634 ETNSITVyASVTLPE molecular association, regulation SHP-2(INDUCES); SH2D1A(INDUCES); APCS(INDUCES) 11806999; 15315965 3 0 0 +NEDD1 NEDD1 Cell cycle regulation Q8NHV4 121441 12q23.1 human T382-p 9379001 PRSINTDtLSKETDS molecular association, regulation cell cycle regulation 19509060 2 1 0 important for binding of NEDD1 with gamma-tubulin +HAUS8 HAUS8 Cell cycle regulation Q9BT25 93323 19p13.11 human S143-p 20609210 RKKSPDLsEAMEMME intracellular localization cell cycle regulation; apoptosis, inhibited 21690413 1 0 0 localization to the spindle +BAD BAD Apoptosis Q92934 572 11q13.1 human S74-p 5209400 VEIRSRHsSYPAGTE Bcl-2_BAD molecular association, regulation; phosphorylation Bcl-2(DISRUPTS) 22096607 2 9 71 mutation of this site to Ala reduces S75 phosphorylation +KARS1 KARS Aminoacyl-tRNA synthetase; EC 6.1.1.6; Ligase; Mitochondrial; Translation; Translation regulation Q15046 3735 16q23.1 human S207-p 9392600 PYEITLLsPCLHMLP intracellular localization; enzymatic activity, induced transcription, induced 19524539; 29029422; 30188867 4 1 0 +MDC1 MDC1 Cell cycle regulation Q14676 9656 6p21.33 human S453-p 453670 QTTTERDsDTDVEEE molecular association, regulation cell cycle regulation NBS1(INDUCES) 18678890 1 34 96 MDC1-NBS1 interaction regulates intra-S-phase checkpoint activation +BAIAP2 IRSp53 Actin-binding; Motility/polarity/chemotaxis Q9UQB8 10458 17q25.3 human T360-p 4751846 YATTENKtLPRSSSM molecular association, regulation cytoskeletal reorganization 14-3-3 zeta(INDUCES) 19933840 1 20 17 +STK3 MST2 Autophagy; EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, STE; Protein kinase, Ser/Thr (non-receptor) Q13188 6788 8q22.2 human S18-p 20831306 LKKLSEDsLTKQPEE molecular association, regulation cell cycle regulation NEK2(DISRUPTS) 21723128 2 3 0 +RIGI RIGI EC 3.6.4.13; Hydrolase O95786 23586 9p21.1 human K172-ub 486285 ENWPKTLkLALEKER CARD_2 activity, induced; molecular association, regulation; ubiquitination transcription, induced; signaling pathway regulation MAVS(INDUCES); NPL4(INDUCES) 17392790; 19484123; 20403326; 23063562; 26471729; 28948228; 29263274 8 3 0 regulates RIG-I activation and RIG-I-mediated IFN-B induction and antiviral capacity; induces ubiquitination at K181; activation of RIG-I mediated by CARD2; K172 is surface accessible, conformational exchange leads to sampling an excited state with an open conformation around T170; regulates antiviral innate immune response signaling; induces DDX58-mediated innate antiviral activity; induces NF-kB signaling; K63-Ubiquitin chains are necessary for activation +SORBS2 ArgBP2 iso2 Adaptor/scaffold; Motility/polarity/chemotaxis O94875-2 8470 4q35.1 human Y50-p 31834902 AVSPMSYyQRPFSPS protein conformation 24475245 1 0 0 reduced self-interaction +GSK3B GSK3B EC 2.7.11.1; EC 2.7.11.26; KINASE; Kinase, protein; Protein kinase, CMGC; Protein kinase, Ser/Thr (non-receptor) P49841 2932 3q13.33 human S389-p 454221 ARIQAAAsTPTNATA intracellular localization; phosphorylation signaling pathway regulation 22039048; 34948382 6 13 0 p38MAPK/GSK-3beta/beta-catenin signaling pathway; inhibits mTOR complex 1 signaling, primes phosphorylation at S9 and inhibits phosphorylation of p70S6K, enhances cardiomyocyte survival and protects from cardiomyocyte hypertrophy; B-catenin nuclear accumulation +KEAP1 KEAP1 Endoplasmic reticulum; Motility/polarity/chemotaxis; Transcription regulation; UBIQUITIN LIGASE; Ubiquitin conjugating system Q14145 9817 19p13.2 human S293-p 4270135 QKCEILQsDSRCKDY transcription, inhibited 30576774 1 2 0 NQO1, Nrf2 expression reduced +NCBP1 NCBP1 RNA processing; Spliceosome; Translation Q09161 4686 9q22.33 human S22-p 1219020 PHKRRKTsDANETED RNA splicing, altered 10973943 1 45 29 +SHOC2 SHOC2 Adaptor/scaffold; Protein phosphatase, regulatory subunit Q9UQ13 8036 10q25.2 human S297-p 31905007 GLRYNRLsAIPRSLA LRR_8 protein degradation; ubiquitination cell growth, inhibited; cell motility, inhibited 29383184 1 2 0 +FLNA FLNA Actin-binding; Motility/polarity/chemotaxis; Nuclear receptor co-regulator P21333 2316 Xq28 human S2152-p 451357 TRRRRAPsVANVGSH Filamin molecular association, regulation; protein stabilization cell cycle regulation; carcinogenesis, induced; cell motility, induced; cell adhesion, induced; transcription, altered; cell motility, altered; apoptosis, inhibited; cytoskeletal reorganization MKL1(INDUCES); LPAR1(INDUCES); GPIbA(INDUCES); CCND1(DISRUPTS) 12198493; 15024089; 16442073; 20179208; 25944616; 28348077; 32195017; 36577757 19 80 999 +Fer Fer EC 2.7.10.2; KINASE; Kinase, protein; Oncoprotein; Protein kinase, TK; Protein kinase, tyrosine (non-receptor) P70451 14158 17|17 E1.1 mouse Y715-p 448461 RQEDGGVySSSGLKQ PK_Tyr_Ser-Thr cell cycle regulation; cell motility, altered 18515860 3 34 611 +USP15 USP15 DEUBIQUITINASE; EC 3.4.19.12; Protease; Ubiquitin conjugating system; Ubiquitin-specific protease Q9Y4E8 9958 12q14.1 human T149-p 1868913300 GNMNNVVtRRFSKAD Ubiquitin_3 molecular association, regulation; ubiquitination; intracellular localization SART3(DISRUPTS) 31330151 1 1 0 inhibits deubiquitination of PRP31 +Gabrg2 GABRG2 Channel, chloride; Channel, ligand-gated; Membrane protein, integral; Membrane protein, multi-pass; Transporter; Transporter, ion channel P22723 14406 11 A5|11 24.8 cM mouse K368-ub 14694706 NRKPSKDkDKKKKNP Neur_chan_memb protein degradation; receptor internalization, altered 19815531 1 0 0 regulation of the late endosomal/lysosomal trafficking of GABA receptors, regulation of synaptic transmission +MAPT Tau iso8 ACETYLTRANSFERASE; Acetyltransferase; Cytoskeletal P10636-8 4137 17q21.31 human K259-ac 1881568102 DLKNVKSkIGSTENL molecular association, regulation 34426645 1 0 0 reduced tau microtuble interactions +Pou5f1 Oct4 DNA-binding; Transcription factor P20263 18999 17 B1|17 18.69 cM mouse K118-sm 486291 ADRPNAVkLEKVEPT protein stabilization cell differentiation, inhibited; cell growth, induced; transcription, induced 17496161 4 0 0 +IRS1 IRS1 Adaptor/scaffold; Motility/polarity/chemotaxis P35568 3667 2q36.3 human K1189-ub 1873529900 LDLVKDFkQCPQECT molecular association, regulation; phosphorylation cell growth, induced; signaling pathway regulation IGF1R(INDUCES) 33991522 1 0 0 regulates IRS1-tyrosine phosphorylation and IGF1-mediated downstream signaling +ABI1 Abi-1 Adaptor/scaffold; Motility/polarity/chemotaxis Q8IZP0 10006 10p12.1 human S392-p 12626405 VQENIADsPTPPPPP molecular association, regulation cell motility, altered; cytoskeletal reorganization 21419341 1 1 0 regulates WRC (WAVE2 regulatory complex) interaction with Arp2/3 and lamellipodial protrusion +H3C1 H3 DNA-binding P68431 8350 6p22.2 human K27-m1 465522 LATKAARkSAPATGG Histone apoptosis, induced 19609857 22 20 47 induced by staurosporine +TFAP4 AP-4 DNA-binding; Transcription factor Q01664 7023 16p13.3 human S139-p 470462 DKDEGIGsPDIWEDE protein degradation; molecular association, regulation; intracellular localization cell cycle regulation BTRC(INDUCES) 24500709 1 24 0 +Scn2a SCN2A Channel, sodium; Membrane protein, integral; Membrane protein, multi-pass P04775 24766 3q21 rat S1112-p 6003508 VPIALGEsDFENLNT Na_trans_assoc intracellular localization 19064667 1 0 0 regulates SCN2A accumulation at the axonal initial segment (AIS) and interaction with ankyrin G +FLT4 VEGFR3 EC 2.7.10.1; KINASE; Kinase, protein; Membrane protein, integral; Protein kinase, TK; Protein kinase, tyrosine (receptor) P35916 2324 5q35.3 human Y1230-p 4119675 RHSLAARyYNWVSFP molecular association, regulation; enzymatic activity, induced cell motility, induced; cell growth, induced GRB2(INDUCES) 16076871 2 0 1 +Irs2 IRS2 Adaptor/scaffold; Motility/polarity/chemotaxis P81122 384783 8 A1.1|8 5.35 cM mouse S303-p 3217341 EFRPRSKsQSSGSSA molecular association, regulation signaling pathway regulation PIK3R1(DISRUPTS) 23775122 3 39 26 +CTNNB1 CTNNB1 Actin-binding; Cell adhesion; Motility/polarity/chemotaxis; Nuclear receptor co-regulator; Oncoprotein; Transcription factor P35222 1499 3p22.1 human Y489-p 462002 QNAVRLHyGLPVVVK molecular association, regulation; intracellular localization transcription, induced LEF-1(INDUCES); CDH2(DISRUPTS) 17618275; 32075752 3 8 91 +MIF MIF Amino Acid Metabolism - phenylalanine; Amino Acid Metabolism - tyrosine; Apoptosis; Cell development/differentiation; Cytokine; EC 5.3.2.1; EC 5.3.3.12; Isomerase P14174 4282 22q11.23 human T113-gl 48990004 NVGWNNStFA_____ MIF molecular association, regulation carcinogenesis, inhibited; cell growth, inhibited; cell motility, inhibited EGFR(INDUCES) 26280537 1 1 0 binds to EGFR and blocks EGF binding to EGFR +POLH POLH DNA repair, damage; EC 2.7.7.7; Transferase Q9Y253 5429 6p21.1 human K589-sm 1877365911 SKLEESSkATPAEMD intracellular localization; enzymatic activity, inhibited 32350109 1 1 0 +BECN1 beclin 1 Adaptor/scaffold; Autophagy; Membrane protein, peripheral Q14457 8678 17q21.31 human T388-p 56689904 EEVEKGEtRFCLPYR APG6 molecular association, regulation autophagy, induced Bcl-2(DISRUPTS); PIK3C3(INDUCES); ATG14(INDUCES) 27304906 1 0 0 +Grin2b NMDAR2B Channel, calcium; Channel, ligand-gated; Membrane protein, integral; Membrane protein, multi-pass Q00960 24410 4q43 rat Y1472-p 448167 GSSNGHVyEKLSSIE NMDAR2_C molecular association, regulation; receptor recycling, induced neural plasticity; endocytosis, induced PSD-95(INDUCES) 16887807; 22819974; 23376245; 24769228; 33558223 42 1 104 +SPIC SPIC DNA-binding Q8N5J4 121599 12q23.2 human Y191-p 15570419 KIRRKLTyQFSEAIL Ets intracellular localization cell adhesion, induced; transcription, induced 35420633 1 0 3 +GJA1 GJA1 Channel, misc.; Membrane protein, integral; Membrane protein, multi-pass; Motility/polarity/chemotaxis P17302 2697 6q22.31 human S279-p 448853 SSPTAPLsPMSPPGY protein degradation; protein stabilization; molecular association, regulation; ubiquitination; intracellular localization; activity, inhibited; protein conformation carcinogenesis, induced; carcinogenesis, inhibited; cell motility, induced; apoptosis, induced; cell growth, inhibited; signaling pathway regulation; endocytosis, induced; cell growth, induced; cytoskeletal reorganization CLTA(INDUCES) 15958277; 18047584; 22737133; 23828237; 24399133; 24492000; 24742583; 26033246; 33255329; 35949588 42 6 1 +TDP1 TDP1 DNA repair, damage; EC 3.1.4.-; Phosphodiesterase Q9NUW8 55775 14q32.11 human R361-m2 1883845000 LIGSTPGrFQGSQKD enzymatic activity, induced DNA repair, induced 35705029 1 0 0 +MAPT Tau iso8 ACETYLTRANSFERASE; Acetyltransferase; Cytoskeletal P10636-8 4137 17q21.31 human T175-p 449077 ATRIPAKtPPAPKTP intracellular localization apoptosis, induced; cytoskeletal reorganization TUBB1(DISRUPTS) 19046355; 25573097; 29298849 10 8 0 fibril formation; colocalization- a subset of pThr 231 tau pathology is also pThr 175 positive; T175 phosphorylation induced increased fibril formation and cell death. +CHRM1 mAChR m1 GPCR, family 1; Membrane protein, integral; Membrane protein, multi-pass; Receptor, GPCR P11229 1128 11q12.3 human S228-p 15721213 ELAALQGsETPGKGG 7tm_1 molecular association, regulation ARRB1(INDUCES) 28652372 2 2 1 followed by arrestin-dependent ERK phosphorylation +Ntrk1 TrkA EC 2.7.10.1; KINASE; Kinase, protein; Membrane protein, integral; Oncoprotein; Protein kinase, TK; Protein kinase, tyrosine (receptor) P35739 59109 2q34 rat Y684-p 447764 DIYSTDYyRVGGRTM PK_Tyr_Ser-Thr molecular association, regulation; enzymatic activity, induced cell cycle regulation; cytoskeletal reorganization; cell growth, altered DNAJA3(INDUCES) 10656690; 14647472; 15753086 14 3 6 +SLC12A5 KCC2 Membrane protein, integral; Membrane protein, multi-pass; Transporter; Transporter, SLC family Q9H2X9 57468 20q13.12 human T1030-p 10045602 DPEKVHLtWTKDKSV activity, inhibited 19665974; 29092909 9 5 1 +Glp1r GLP1R GPCR, family 2; Membrane protein, integral; Membrane protein, multi-pass; Receptor, GPCR P32301 25051 20p12 rat S445-p 451383 CPTSSVSsGATVGSS receptor desensitization, altered 8702711 1 0 0 +LDLRAP1 LDLRAP1 Q5SW96 26119 1p36.11 human S186-p 482659 KEKRDKAsQEGGDVL PID_2 cell cycle regulation 21778424 1 9 9 +Nr3c1 GR DNA-binding; Mitochondrial; Nuclear receptor; Transcription factor P06536 24413 18p11 rat T171-p 451795 TSATGCAtPTEKEFP GCR transcription, inhibited 9603939 7 11 0 +SND1 SND1 RNA-binding; Transcription, coactivator/corepressor Q7KZF4 27044 7q32.1 human T103-p 18015998 CFTIENKtPQGREYG SNase molecular association, regulation; intracellular localization; phosphorylation cell cycle regulation; carcinogenesis, induced; DNA repair, induced; apoptosis, inhibited G3BP-1(INDUCES) 28011284; 35271349 2 8 1 induces phosphorylation of AKT and H2AX; recruitment of SND1 into SGs (stress granules) +Ywhab 14-3-3 beta Adaptor/scaffold P35213 56011 3q42 rat S60-p 450226 VVGARRSsWRVISSI 14-3-3 intracellular localization transcription, altered 12619878 5 0 10 Double mutant inhibited a MEF2 reporter and promotes nuclear localization of HDAC4/GFP. +Fundc1 FUNDC1 Membrane protein, multi-pass; Mitochondrial Q9DB70 72018 X|X A1.2 mouse S17-p 2025377 DYESDDEsYEVLDLT autophagy, induced 31901590 6 7 0 Induced mitophagy +Dpysl2 CRMP-2 Microtubule-binding; Motility/polarity/chemotaxis P47942 25416 15p12 rat S518-p 448081 KTVTPASsAKTSPAK receptor recycling, inhibited; protein degradation; molecular association, regulation neural plasticity TUBA1A(DISRUPTS); endophilin A2(DISRUPTS); ROCK2(DISRUPTS) 24036111; 32848595 9 33 17 +CANX Calnexin Calcium-binding; Endoplasmic reticulum; Membrane protein, integral; Motility/polarity/chemotaxis P27824 821 5q35.3 human S564-p 456360 EEDGGTVsQEEEDRK molecular association, regulation SEC62(INDUCES); TRAP(INDUCES); MRPL12(INDUCES); SEC61A1(INDUCES); SEC61B(INDUCES) 22314232 7 85 48 +CEP55 CEP55 Cancer Testis Antigen (CTA); Cell cycle regulation Q53EZ4 55165 10q23.33 human S428-p 457629 KVAASPKsPTAALNE activity, induced; molecular association, regulation cell cycle regulation PLK1(INDUCES) 16198290 1 38 12 +NCF1 p47phox EC 1.-.-.-; Oxidoreductase P14598 653361 7q11.23 human S328-p 449404 QDAYRRNsVRFLQQR NECFESHC molecular association, regulation; intracellular localization; phosphorylation; enzymatic activity, induced cell growth, induced; signaling pathway regulation CYBA(INDUCES); ACTB(INDUCES) 10559253; 12056906; 16375898; 22460559; 31736979; 31811262; 33139577; 35108370 22 0 0 induces ROS production; LPS-induced activation of p38MAPK and ERK1/2 signaling pathways; induces NADPH oxidase activity, regulates Raf/MEK/ERK1/2/p47phox pathway; regulates ERK1/2 phosphorylation in cells treated with TNF-alpha +CAMK2A CAMK2A EC 2.7.11.17; KINASE; Kinase, protein; Protein kinase, CAMK; Protein kinase, Ser/Thr (non-receptor) Q9UQM7 815 5q32 human T305-p 448802 KLKGAILtTMLATRN molecular association, regulation; intracellular localization NMDAR2B(DISRUPTS) 16436603; 21768120 24 5 1 T305/306 autophosphorylation +Ptprc CD45 EC 3.1.3.48; Membrane protein, integral; Motility/polarity/chemotaxis; PHOSPHATASE; Receptor protein phosphatase, tyrosine P06800 19264 1 E4|1 60.73 cM mouse S998-p 449975 DESSDDDsDSEETSK Y_phosphatase enzymatic activity, induced 10066810 1 4 0 +ACBD5 ACBD5 iso2 Lipid-binding; Membrane protein, integral Q5T8D3-2 91452 10p12.1 human S269-p 34501844 DSEVYCDsMEQFGQE molecular association, regulation VAPB(DISRUPTS) 35019937 1 2 0 +ADARB1 RED1 EC 3.5.4.37; Hydrolase; Nucleolus; RNA-binding P78563 104 21q22.3 human S211-p 23138309 GDLSLSAsPVPASLA enzymatic activity, induced 29694894 1 1 1 regulation of the steady-state levels of miR-200s; metastasis suppressor activity +PPARGC1A PGC-1 alpha Nuclear receptor co-regulator; Transcription, coactivator/corepressor Q9UBK2 10891 4p15.2 human K224-m1 1878289800 NDDPPHTkPTENRNS activity, inhibited cell growth, induced; apoptosis, inhibited 31629659 1 1 0 inhibits PGC-1a-mediated NRF1/2 activation and inhibits ROS productiion and mitochondrial biogenesis +Esrra ERR1 DNA-binding; Nuclear receptor; Transcription regulation O08580 26379 19 A|19 5.08 cM mouse S19-p 487492 YIKAEPAsPDSPKGS sumoylation transcription, inhibited 17676930; 18063693 2 22 0 induces sumoylation at ERR1-K14; increases sumoylation of ERR1 at K14 +GPSM2 GPSM2 G protein regulator, misc. P81274 29899 1p13.3 human T457-p 18412000 LKGKKYKtNSSTKVL cell cycle regulation; cell growth, altered 20589935 1 0 0 plays a critical role in cytokinesis +Llgl1 LLGL1 Cell adhesion; Cytoskeletal; Motility/polarity/chemotaxis Q80Y17 16897 11 B2|11 37.81 cM mouse S654-p 449915 GPLSRVKsLKKSLRQ intracellular localization 11809830 2 1 4 +BACE1 BACE EC 3.4.23.46; Membrane protein, integral; Protease P56817 23621 11q23.3 human K279-ac 478258 QDLKMDCkEYNYDKS Asp protein stabilization; intracellular localization 17425515 1 1 0 regulates translocation through secretory pathway +TP63 p63 DNA-binding; Transcription factor Q9H3D4 8626 3q28 human T281-p 912008300 QYVEDPItGRQSVLV P53 transcription, induced 29559659 1 0 0 Induction of LCE1C and ANXA8L1 transcription +Kif5c KIF5C P28738 16574 2 C1.1|2 28.68 cM mouse S176-p 54436200 CTERFVSsPEEVMDV Kinesin molecular association, regulation; intracellular localization 27013971 1 1 0 S176D binds poorly to microtubules, S176A binds strongly, S176A moters remained stationary 50%, 176D remainded stationary 20%, 176D diffuse in cytoplasm, S176A associated with microtubules, KIF5C transport to neurite tips +MAPK1 ERK2 EC 2.7.11.24; KINASE; Kinase, protein; Protein kinase, CMGC; Protein kinase, Ser/Thr (non-receptor) P28482 5594 22q11.22 human Y187-p 447594 HTGFLTEyVATRWYR Pkinase activity, induced; protein degradation; molecular association, regulation; intracellular localization; protein conformation; phosphorylation; enzymatic activity, induced cell differentiation, inhibited; cell cycle regulation; carcinogenesis, induced; apoptosis, altered; cell motility, induced; transcription, induced; transcription, altered; signaling pathway regulation; cell growth, induced; cell differentiation, induced; cell motility, altered; cytoskeletal reorganization; transcription, inhibited; cell growth, altered G-beta 1(INDUCES); leupaxin(NOT_REPORTED); GSK3B(INDUCES); p90RSK(INDUCES); KSR(INDUCES); NFkB-p100(DISRUPTS); ERK2(INDUCES); TACE(INDUCES) 10597231; 10925301; 11352917; 12609989; 12808105; 15004239; 15059947; 16149052; 16397900; 17562849; 17667937; 17685427; 18042541; 18045996; 18519681; 18658095; 18775330; 19060905; 19088846; 19106095; 19144315; 20122898; 20231899; 20868520; 21478863; 21530327; 21561860; 21685939; 21726627; 21730054; 21893193; 21917714; 21980390; 22385658; 23644655; 25538243; 25730857; 26079947; 26686085; 27323830; 28574827; 30987999; 31722981; 31736979; 31964804; 33667549; 34017102; 34226680; 36289618; 9124279 1163 158 4003 autoamplifcation of NFAT-c1, which promotes osteoclast differentiation, suppressed by MLN4924 +Brsk2 BRSK2 EC 2.7.11.1; EC 2.7.11.26; KINASE; Kinase, protein; Protein kinase, CAMK; Protein kinase, Ser/Thr (non-receptor) Q69Z98 75770 7|7 F5 mouse T175-p 456031 VGDSLLEtSCGSPHY Pkinase intracellular localization; enzymatic activity, induced cytoskeletal reorganization BRSK1(INDUCES); Tau(INDUCES) 17482548; 29698519 5 1 1 activation of Sad kinases in the axon during development; Sad kinases are required for the survival of cortical neurons; LKB1 phosphorylates Brsk1 and Brsk2.; Tau S262 is phosphoryated by LKB1 only in the presence of BRSK2. +RBL2 Rb-like 2 Transcription, coactivator/corepressor; Tumor suppressor Q08999 5934 16q12.2 human S952-p 449732 DSRSHQNsPTELNKD RB_B molecular association, regulation cell cycle regulation E2F4(DISRUPTS) 11157749 3 15 1 +Cacna1b CACNA1B Channel, calcium; Membrane protein, integral; Membrane protein, multi-pass Q02294 257648 3p13 rat S2016-p 25792205 TQPAPNAsPMKRSIS protein conformation RIMS1(INDUCES) 22920258 1 1 0 Calcium influx is increased due to open channel probability, facilitating neurotransmitter release by increasing number of docked vesicles at synaptic cleft. +PI4KB PIK4CB iso2 Carbohydrate Metabolism - inositol phosphate; EC 2.7.1.67; Kinase, lipid; Motility/polarity/chemotaxis Q9UBF8-2 5298 1q21.3 human S496-p 457623 GDIRRRLsEQLAHTP intracellular localization 16606619 1 56 12 S496-phosphorylated PIK4CB localizes in the nucleus +Oprm1 MOR-1 GPCR, family 1; Membrane protein, integral; Membrane protein, multi-pass; Receptor, GPCR P33535 25601 1q11 rat S266-p 447782 LKSVRMLsGSKEKDR 7tm_1 receptor desensitization, altered 10908300; 9326307 3 0 2 +NKX3-1 NKX3-1 DNA-binding; Transcription factor; Tumor suppressor Q99801 4824 8p21.2 human S48-p 3078000 RQGGRTSsQRQRDPE molecular association, regulation DNA(DISRUPTS) 11980664 1 0 0 +Stmn1 STMN1 Cytoskeletal P54227 16765 4 D3|4 66.76 cM mouse S25-p 448555 QAFELILsPRSKESV Stathmin protein stabilization carcinogenesis, induced; cell motility, induced; cell growth, induced; apoptosis, induced; cytoskeletal reorganization; signaling pathway regulation 21646391; 22698694; 36484700 52 122 91 +Kif23 KIF23 Microtubule-binding; Motility/polarity/chemotaxis; Motor E9Q5G3 71819 9|9 B mouse S904-p 459840 TGSRKRRsSTLAPAQ intracellular localization cell cycle regulation; cytoskeletal reorganization 15199097 5 18 267 regulates cytokinesis +FANCD2 FANCD2 DNA repair, damage Q9BXW9 2177 3p25.3 human T608-p 470036 NLSDEQCtQVTSLLQ FancD2 activity, induced; molecular association, regulation; ubiquitination; intracellular localization signaling pathway regulation DNA(INDUCES) 37392383 2 1 0 regulates the FA pathway +SPRED2 SPRED2 Motility/polarity/chemotaxis; Vesicle Q7Z698 200734 2p14 human Y228-p 471403 EKIWMTGyEDYRHAP protein degradation 17094949 1 0 1 Pervanadate induced Spred-2 degredation in ME4405 cells which is dependent on ubiquitination. +Pdx1 PDX1 DNA-binding; Transcription factor P52946 18609 5 G3|5 86.84 cM mouse S232-p 13421406 EQDCAVTsGEELLAV transcription, inhibited 20339896 1 0 0 +PTPN22 PTPN22 EC 3.1.3.48; Motility/polarity/chemotaxis; PHOSPHATASE; Protein phosphatase, tyrosine (non-receptor) Q9Y2R2 26191 1p13.2 human S35-p 1725300 FLKLKRQsTKYKADK enzymatic activity, inhibited; protein conformation 18056643 1 0 0 I-C11 compound inhibits phosphatase activity of PTPN22 +Ulk1 ULK1 Autophagy; EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, Other; Protein kinase, Ser/Thr (non-receptor) O70405 22241 5|5 F mouse S777-p 4699310 TRMFSVGsSSSLGST autophagy, induced 21258367 1 2 0 +UVRAG UVRAG Autophagy Q9P2Y5 7405 11q13.5 human S522-p 471489 QYKTPPPsYNSALAQ molecular association, regulation carcinogenesis, induced; cell growth, induced; autophagy, inhibited; signaling pathway regulation SMURF1(DISRUPTS); RUBCNL(INDUCES) 30686098 2 3 1 inhibits Smurf1-mediated ubiquitination at K517 and K559 +PRKCQ PKCT EC 2.7.11.13; KINASE; Kinase, protein; Protein kinase, AGC; Protein kinase, Ser/Thr (non-receptor) Q04759 5588 10p15.1 human S695-p 447906 QNMFRNFsFMNPGME Pkinase_C protein stabilization; molecular association, regulation; enzymatic activity, induced PDK1(INDUCES) 11772397; 15364937; 16252004 5 28 49 assayed in vitro +Cebpb C/EBP-beta DNA-binding; Motility/polarity/chemotaxis; Transcription factor P28033 12608 2 H3|2 87.58 cM mouse T188-p 447878 SSSSPPGtPSPADAK activity, induced; molecular association, regulation; protein conformation; phosphorylation cell growth, inhibited; cell differentiation, induced; transcription, induced; transcription, inhibited; signaling pathway regulation; transcription, altered; cell growth, altered ERK2(INDUCES); MED1(INDUCES); C/EBP-beta(INDUCES) DNA(INDUCES) 11756662; 15367685; 15985551; 17264204; 17601773; 18339625; 19244213; 19478079; 21804532; 21847090; 26114754 33 11 14 activates G-CSF promoter; induces muscle mass loss; the 3'UTRC/EBP-beta alters target gene speci?city +SUPT5H SPT5 RNA-binding; Transcription, coactivator/corepressor O00267 6829 19q13.2 human T791-p 458817 TPMYGSQtPLQDGSR transcription, altered 16427012 2 10 90 required for c-fos induction and activation in vivo +Prkar2a PKAR2A Protein kinase, regulatory subunit P12368 29699 8q32 rat S97-p 458326 SKFTRRVsVCAETFN molecular association, regulation; phosphorylation PKACA(DISRUPTS) 18550536 7 77 179 regulates PKA-dependent substrate phosphorylation and calcium signaling in cardiac cells +HBEGF HBEGF Cell surface; Membrane protein, integral Q99075 1839 5q31.3 human S207-p 2872001 VKLGMTNsH______ cell growth, altered 16557002 1 0 0 +Sgk3 SGK3 EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, AGC; Protein kinase, Ser/Thr (non-receptor) Q9ERE3 170755 1 A2|1 2.08 cM mouse S486-p 448196 DDAFVGFsYAPPSED Pkinase_C enzymatic activity, induced cell differentiation, altered; cell growth, altered 15871460 5 0 0 S486 site is indispensible for kinase activation. +TYMS TYMS Cofactor and Vitamin Metabolism - one carbon pool by folate; DNA repair, damage; EC 2.1.1.45; METHYLTRANSFERASE; Methyltransferase; Mitochondrial; Nucleotide Metabolism - pyrimidine P04818 7298 18p11.32 human T306-gl 1875343300 EGYNPHPtIKMEMAV Thymidylat_synt protein stabilization; phosphorylation TYMS(INDUCES) 34845374 1 1 0 dimer stabilization by intra- and inter-monomer interactions; reciprocal phosphorylation/O-GlcNAcylation with T306 O-GlcAc site +Stk4 MST1 Autophagy; EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, STE; Protein kinase, Ser/Thr (non-receptor) Q9JI11 58231 2|2 H3 mouse T387-p 450050 TMKRRDEtMQPAKPS enzymatic activity, induced cell adhesion, altered 12223493 6 2 7 +NFATC1 NFAT2 DNA-binding; Transcription factor O95644 4772 18q23 human S409-p 63036600 LSPTSYMsPTLPALD protein stabilization 28235034 1 0 0 +Rcan1 RCAN1 Inhibitor Q9JHG6 54720 16 C4|16 53.6 cM mouse S165-p 456023 FLISPPAsPPVGWKQ Calcipressin molecular association, regulation PPP3CA(DISRUPTS) 22864830 7 38 6 +HMMR HMMR Receptor, misc. O75330 3161 5q34 human T703-p 460367 KENFALKtPLKEGNT HMMR_C intracellular localization 28993511 1 10 6 nuclear localization +TP63 p63 iso2 DNA-binding; Transcription factor Q9H3D4-2 8626 3q28 human S358-p 1875424900 HLLQKQTsIQSPSSY molecular association, regulation DNA(INDUCES) 34761935 0 1 0 +CLOCK CLOCK ACETYLTRANSFERASE; Acetyltransferase; DNA-binding; EC 2.3.1.48; Transcription factor O15516 9575 4q12 human K67-sm 27992507 MLPGNARkMDKSTVL HLH molecular association, regulation cell cycle regulation; cell growth, induced; transcription, induced; signaling pathway regulation ER-alpha(INDUCES) 23160374 1 0 0 induces ER-alpha signaling +Map3k5 ASK1 EC 2.7.11.25; KINASE; Kinase, protein; Protein kinase, STE; Protein kinase, Ser/Thr (non-receptor) O35099 26408 10|10 A3 mouse S1040-p 451423 EDHSAPPsPEEKDSG enzymatic activity, inhibited; phosphorylation 35438255 2 32 0 inhibits p38 phosphorylation +Mapk8 JNK1 EC 2.7.11.24; KINASE; Kinase, protein; Protein kinase, CMGC; Protein kinase, Ser/Thr (non-receptor) Q91Y86 26419 14|14 B mouse Y185-p 447645 TSFMMTPyVVTRYYR Pkinase protein degradation; acetylation; molecular association, regulation; enzymatic activity, induced cell cycle regulation; carcinogenesis, induced; carcinogenesis, inhibited; cell growth, inhibited; apoptosis, induced; cell motility, induced; cell motility, inhibited; transcription, induced; signaling pathway regulation; transcription, altered; cell growth, induced; apoptosis, inhibited; transcription, inhibited p300(INDUCES); GSK3B(INDUCES); CTNNB1(INDUCES); PCAF(INDUCES) 18032450; 18952597; 21887248; 26306048; 34914791; 34962918; 35370650; 35637461; 36070687; 36310322 270 48 1269 +WEE1 Wee1 EC 2.7.10.2; KINASE; Kinase, protein; Protein kinase, Other; Protein kinase, Ser/Thr (non-receptor); Protein kinase, tyrosine (non-receptor) P30291 7465 11p15.4 human S211-p 25316773 SSVKLRGsSLFMDTE protein degradation; molecular association, regulation BTRC(INDUCES) 24817118 1 1 1 +ROCK1 ROCK1 EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, AGC; Protein kinase, Ser/Thr (non-receptor) Q13464 6093 18q11.1 human S1341-p 1216639 TRSTANQsFRKVVKN intracellular localization cytoskeletal reorganization 21685893 2 14 32 inhibits apical constriction +Slc12a5 KCC2 iso2 Membrane protein, integral; Membrane protein, multi-pass; Transporter; Transporter, SLC family Q63633-2 171373 3q42 rat S937-p 2025121 IQSITDEsRGSIRRK SLC12 activity, induced; protein conformation 24849604 3 2 0 increase transport kinetics of KCC2 +PTRH2 PTRH2 EC 3.1.1.29; Hydrolase; Mitochondrial Q9Y3E5 51651 17q23.1 human S87-p 4206800 GKVAAQCsHAAVSAY PTH2 apoptosis, altered; cell adhesion, altered 18703509 1 0 0 associated with anoikis (cell death induced by detachment from the extracellular matrix) +GJA1 GJA1 Channel, misc.; Membrane protein, integral; Membrane protein, multi-pass; Motility/polarity/chemotaxis P17302 2697 6q22.31 human Y313-p 454254 SEQNWANySAEQNRM Connexin43 molecular association, regulation; intracellular localization DBN1(DISRUPTS) 30448479 5 20 298 +LZTS2 LZTS2 Nuclear export Q9BRK4 84445 10q24.31 human S277-p 1871717500 HSDSGRSsSSKSTGS protein degradation; molecular association, regulation; ubiquitination; phosphorylation carcinogenesis, induced; cell motility, induced; cell growth, induced; signaling pathway regulation BTRC(INDUCES) 33420362 1 0 0 induces phosphorylation of downstream targets thus inducing the PI3K/AKT signaling pathway +SSTR2 SSTR2 GPCR, family 1; Membrane protein, integral; Membrane protein, multi-pass; Receptor, GPCR P30874 6752 17q25.1 human S343-p 7652105 DDGERSDsKQDKSRL receptor desensitization, induced; receptor internalization, induced; receptor recycling, induced; receptor internalization, altered 21330405; 21343287; 22538189; 24565897; 24637622; 25012983 10 0 0 +CDC42BPA MRCKA EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, AGC; Protein kinase, Ser/Thr (non-receptor) Q5VT25 8476 1q42.13 human S234-p 12612500 MEDGTVQsSVAVGTP Pkinase enzymatic activity, induced cytoskeletal reorganization 11283256 1 0 0 +YAP1 YAP1 Oncoprotein; Transcription, coactivator/corepressor P46937 10413 11q22.1 human T143-p 3190678 AVSPGTLtPTGVVSG protein stabilization; ubiquitination; intracellular localization cell cycle regulation; cell motility, induced 26933062; 35705994 2 6 51 mitotic shift, important for proper mitosis and cytokinesis ; inhibits ubiquitination +DRD1 DRD1 GPCR, family 1; Membrane protein, integral; Membrane protein, multi-pass; Receptor, GPCR P21728 1812 5q35.2 human T245-p 1869357205 AKNCQTTtGNGKPVE 7tm_1 molecular association, regulation ARR3(INDUCES) 32503917 1 0 0 +JUNB JunB Motility/polarity/chemotaxis; Oncoprotein; Transcription factor P17275 3726 19p13.13 human T104-p 1814000 GVITTTPtPPGQYFY Jun activity, induced; molecular association, regulation transcription, altered DNA(INDUCES) 9889198 1 8 2 Phosphorylation of JunB increases cooperative binding with c-Maf to DNA. +IGF2BP1 IGF2BP1 RNA-binding; Translation Q9NZI8 10642 17q21.32 human Y396-p 458348 SVTGAAPySSFMQAP intracellular localization carcinogenesis, inhibited; apoptosis, induced; RNA stability, inhibited; translation, induced 33388443 6 0 0 +FAF1 FAF1 Apoptosis; Nuclear receptor co-regulator Q9UNN5 11124 1p32.3 human S582-p 480070 KLRIRTPsGEFLERR UBX molecular association, regulation; intracellular localization TGFBR3(DISRUPTS); BTRC(DISRUPTS); VCP(DISRUPTS) 28443643 1 37 218 inhibits membrane localization +PER2 PER2 Nuclear receptor co-regulator; Nucleolus; Transcription factor O15055 8864 2q37.3 human S480-p 50596800 PVPHSGSsGYGSLGS protein degradation; molecular association, regulation BTRC(INDUCES) 30425162 4 0 0 +NHERF1 NHERF Adaptor/scaffold; Motility/polarity/chemotaxis O14745 9368 17q25.1 human S290-p 450313 PALVRSAsSDTSEEL EBP50_C molecular association, regulation; protein conformation SLC34A1(INDUCES) 30696771 5 55 96 regulates phosphate uptake by SLC34A1 +MAPRE1 EB1 Cytoskeletal; Motility/polarity/chemotaxis Q15691 22919 20q11.21 human S155-p 476322 KPKKPLTsSSAAPQR intracellular localization carcinogenesis, induced; carcinogenesis, inhibited; cell motility, induced; cell motility, inhibited; signaling pathway regulation; cell growth, induced; apoptosis, inhibited; cytoskeletal reorganization 24930764; 30250248 2 11 0 enhances cytotoxicity +HSP90AB1 HSP90B Chaperone; Heat shock protein P08238 3326 6p21.1 human S226-p 454114 KEREKEIsDDEAEEE HSP90 activity, induced; molecular association, regulation; protein processing; intracellular localization; protein conformation apoptosis, altered; apoptosis, induced HSP40(DISRUPTS); AHSA1(DISRUPTS); PXR(INDUCES); APAF(DISRUPTS); CACYBP(INDUCES); DNAJC7(DISRUPTS); HSC70(DISRUPTS); CDC37(DISRUPTS); GR(DISRUPTS) 18591256; 25995454; 29854279; 34359868 8 93 101 induced by triptolide +TNS3 tensin 3 Adaptor/scaffold; Motility/polarity/chemotaxis Q68CZ2 64759 7p12.3 human Y1173-p 9824600 QDTSKFWyKADISRE SH2 molecular association, regulation cell motility, altered; cell growth, altered P130Cas(INDUCES); KHDRBS1(INDUCES); FAK(INDUCES) 19732724 1 0 0 contributes to tumorigenesis and metastasis +HSPA1A HSP70 Chaperone; Heat shock protein; Motility/polarity/chemotaxis P0DMV8 3303 6p21.33 human R447-me 1877047300 IQVYEGErAMTKDNN HSP70 protein stabilization carcinogenesis, induced; cell growth, induced; apoptosis, inhibited RNA(INDUCES) 32699135 1 1 0 binding and stabilization of BCL2 mRNA +mos MOS EC 2.7.11.1; KINASE; Kinase, protein; Oncoprotein; Protein kinase, Other; Protein kinase, Ser/Thr (non-receptor) P12965 397924 frog S3-p 448658 _____MPsPIPVERF protein stabilization; enzymatic activity, induced 12426378; 16809767 3 1 0 necessary for oocyte maturation and the spindle assembly checkpoint; in Xenopus oocytes, not cell lines +PCLAF PAF DNA repair, damage Q15004 9768 15q22.31 human K15-ub 12327204 SVPGTYRkVVAARAP PAF DNA repair, altered 23000965 1 1 7 +ZAP70 ZAP70 EC 2.7.10.2; KINASE; Kinase, protein; Protein kinase, TK; Protein kinase, tyrosine (non-receptor) P43403 7535 2q11.2 human Y597-p 464391 EQRMRACyYSLASKV enzymatic activity, altered transcription, altered 9624129 1 1 193 +VCP VCP Chaperone; DNA repair, damage; EC 3.6.4.6; Endoplasmic reticulum; Hydrolase P55072 7415 9p13.3 human K315-m3 15381938 AIAPKREkTHGEVER AAA enzymatic activity, inhibited 23349634 5 6 2 inhibits ATPase activity +MAP3K14 Nik EC 2.7.11.25; KINASE; Kinase, protein; Protein kinase, STE; Protein kinase, Ser/Thr (non-receptor) Q99558 9020 17q21.31 human S814-p 27259014 DDSEKNPsKASQSSR protein degradation 20501937 2 1 0 IKKA-dependent destabilization of Nik +Tnik TNIK EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, STE; Protein kinase, Ser/Thr (non-receptor) D3ZZQ0 294917 2q24 rat T187-p 480117 RTVGRRNtFIGTPYW Pkinase enzymatic activity, induced 26645429 1 7 76 +ATG4B ATG4B Autophagy; EC 3.4.22.-; Protease; Ubiquitin conjugating system Q9Y4P1 23192 2q37.3 human S383-p 470896 RLERFFDsEDEDFEI ATG4_LIR molecular association, regulation; enzymatic activity, induced carcinogenesis, induced; autophagy, induced; cell growth, induced LC3A(INDUCES) 26378241; 29232556 3 37 2 +TUBA1A TUBA1A Cytoskeletal; Motility/polarity/chemotaxis P81947 404053 cow Y103-p 6835001 KEDAANNyARGHYTI Tubulin cytoskeletal reorganization 19631231 0 13 530 +PLK1 PLK1 EC 2.7.11.21; KINASE; Kinase, protein; Protein kinase, Other; Protein kinase, Ser/Thr (non-receptor) P53350 5347 16p12.2 human K209-me 1877571000 EYDGERKkTLCGTPN Pkinase enzymatic activity, inhibited cell cycle regulation; cell growth, inhibited 30622182 1 1 0 +Cox5b COX5B EC 1.9.3.1; Energy Metabolism - oxidative phosphorylation; Mitochondrial; Oxidoreductase P19536 12859 1|1 B mouse S70-p 476779 MLPPKAAsGTKEDPN COX5B enzymatic activity, inhibited 24130844 2 1 0 S70A mutant showed a reduced loss of activity under hypoxic conditions. +BUB1B BUB1B EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, Other; Protein kinase, Ser/Thr (non-receptor); Tumor suppressor O60566 701 15q15.1 human T792-p 7652106 PRNSAELtVIKVSSQ enzymatic activity, induced cell cycle regulation 17376779 2 0 0 facilitates chromosome alignment during prometaphase +Cavin1 PTRF Transcription initiation complex O54724 19285 11 D|11 63.95 cM mouse T304-p 2566127 DKLRKSFtPDHVVYA PTRF_SDPR phosphorylation 21282370 2 30 7 regulates phosphorylation of HSL S557 (aka S563) and S651 (aka S660); regulates lipolysis in adipocytes +POLH POLH DNA repair, damage; EC 2.7.7.7; Transferase Q9Y253 5429 6p21.1 human K533-sm 1877365919 TGTEPFFkQKSLLLK intracellular localization; enzymatic activity, inhibited 32350109 1 1 0 +CNTROB LIP8 Cell cycle regulation Q8N137 116840 17p13.1 human S36-p 27565611 QVSSEVTsQLYASLR cell motility, inhibited 23291182 1 0 0 +Cacna1d CACNA1D Channel, calcium; Membrane protein, integral; Membrane protein, multi-pass P27732 29716 16p16 rat S81-p 470135 PPPVGSLsQRKRQQY activity, inhibited 16973824 1 1 1 +SYK Syk EC 2.7.10.2; KINASE; Kinase, protein; Protein kinase, TK; Protein kinase, tyrosine (non-receptor) P43405 6850 9q22.2 human Y352-p 447660 TEVYESPyADPEEIR molecular association, regulation; enzymatic activity, induced CLTC(INDUCES); ITGAM(INDUCES); PLCG1(INDUCES) 18818202; 19289168; 8657103 38 22 248 +AMBRA1 AMBRA1 Autophagy; UBIQUITIN LIGASE; Ubiquitin ligase; Vesicle Q9C0C7 55626 11p11.2 human S52-p 27443426 KRVELPDsPRSTFLL protein degradation; ubiquitination; enzymatic activity, inhibited; activity, inhibited autophagy, inhibited; signaling pathway regulation 23524951; 36476874 4 4 0 +POLL POLL DNA repair, damage; EC 2.7.7.7; Lyase; Transferase Q9UGP5 27343 10q24.32 human K27-p 1876957802 ASSKVLAkIPRREEG intracellular localization DNA repair, induced 32224012 1 0 0 SUMOylation of PolL in response to DNA damage +PRKDC DNAPK DNA repair, damage; EC 2.7.11.1; KINASE; Kinase, protein; Nucleolus; Protein kinase, Ser/Thr (non-receptor); Protein kinase, atypical P78527 5591 8q11.21 human S2023-p 33365500 NGDSDGPsYMSSLSY DNAPKcs_CC3 molecular association, regulation DNA repair, inhibited DNA(INDUCES) 24687855 1 0 0 induces c-NHEJ, restricts end processing +HTT Huntingtin Cytoskeletal P42858 3064 4p16.3 human S114-p 13261664 CENIVAQsVRNSPEF apoptosis, induced 24505464 1 2 0 +Des desmin Cytoskeletal; Motility/polarity/chemotaxis P31001 13346 1 C4|1 38.85 cM mouse S32-p 466343 SLGSPLSsPVFPRAG Filament_head cell cycle regulation 27565725 4 13 31 +APBB1IP RIAM Adaptor/scaffold; Motility/polarity/chemotaxis Q7Z5R6 54518 10p12.1 human Y45-p 462981 PPRAEFNySVGFKDL activity, induced; intracellular localization; protein conformation signaling pathway regulation; cell adhesion, inhibited 30733287 1 0 73 autoinhibited by an intramolecular association, inhibits T cell adhesion +Nkx3-2 NKX3-2 Cell development/differentiation; DNA-binding; Transcription factor P97503 12020 5 B3|5 22.58 cM mouse K260-ub 1593379700 WFQNRRYkTKRRQMA Homeodomain molecular association, regulation apoptosis, inhibited IKKG(INDUCES) 21606193 1 1 0 ubiquitination-dependent interaction with IKKG (aka NEMO) promotes formation of the complex NKX3.2-IKKG(NEMO)-IKKB +Rfc1 RFC1 DNA replication D3ZFT1 89809 14p11 rat T110-p 468618 PVTYISEtDEDDDFL intracellular localization transcription, inhibited 10625661 1 35 26 +Camk2b CAMK2B EC 2.7.11.17; KINASE; Kinase, protein; Protein kinase, CAMK; Protein kinase, Ser/Thr (non-receptor) P08413 24245 14q21 rat T333-p 48915801 MSTAASGtTMGLVEQ molecular association, regulation 26291163 1 1 0 inhibits interaction with F-actin, regulates synaptic plasticity +MDC1 MDC1 Cell cycle regulation Q14676 9656 6p21.33 human T301-p 477987 PPGEDSDtDVDDDSR molecular association, regulation cell cycle regulation NBS1(INDUCES) 18678890 1 24 21 MDC1-NBS1 interaction regulates intra-S-phase checkpoint activation +Nr3c1 GR DNA-binding; Mitochondrial; Nuclear receptor; Transcription factor P06537 14815 18 B3|18 21.09 cM mouse S284-p 3178938 TGDTILSsPSSVALP GCR neural plasticity 35733193 3 13 0 +Smarca2 SMARCA2 EC 3.6.1.-; EC 3.6.4.-; Helicase; Nuclear receptor co-regulator; Transcription, coactivator/corepressor Q6DIC0 67155 19 C1|19 21.17 cM mouse K1549-ac 460623 KKRPNRGkAKPVVSD molecular association, regulation; protein conformation cell growth, induced; transcription, inhibited Rb(DISRUPTS) DNA(DISRUPTS) 14657023 1 0 0 +POLR2A POLR2A EC 2.7.7.48; EC 2.7.7.6; Nucleotide Metabolism - purine; Nucleotide Metabolism - pyrimidine; Transcription initiation complex; Transferase P24928 5430 17p13.1 human S1619-p 447616 SPSYSPTsPSYSPTS RNA_pol_Rpb1_R protein degradation; molecular association, regulation; intracellular localization; enzymatic activity, inhibited; enzymatic activity, induced apoptosis, induced; transcription, induced; transcription, altered; transcription, inhibited CTDSP1(INDUCES); CABIN1(INDUCES); UBN1(INDUCES); HIRA(INDUCES) DNA(INDUCES) 10886368; 10995388; 11425311; 16641292; 17157258; 17259211; 18066052; 18079403; 19901026; 20434984; 20880846; 21159777; 22195966; 25023704; 25561469; 25620562; 26588990; 27099314; 34608337 81 4 0 binds viral RNP and Influenza A virus polymerase; PRC1 mediated repression is achieved by controlling transcriptional burst frequency; controls APA control region in the nervous system and regulates neuronal development +Ppargc1a PGC-1 alpha Nuclear receptor co-regulator; Transcription, coactivator/corepressor O70343 19017 5|5 C1 mouse S570-p 2045307 RMRSRSRsFSRHRSC molecular association, regulation transcription, inhibited; signaling pathway regulation DNA(DISRUPTS) 17554339 4 0 0 regulates decrease glucose production and regulates beta oxidation of fatty acids through Akt/PGC-1 alpha pathway +Jak2 JAK2 EC 2.7.10.2; KINASE; Kinase, protein; Oncoprotein; Protein kinase, TK; Protein kinase, tyrosine (non-receptor) Q62689 24514 1q52 rat Y1007-p 448407 VLPQDKEyYKVKEPG PK_Tyr_Ser-Thr enzymatic activity, induced 15065871 80 5 15 +PKM PKM Carbohydrate Metabolism - glycolysis and gluconeogenesis; Carbohydrate Metabolism - pyruvate; EC 2.7.1.40; KINASE; Kinase, other; Mitochondrial; Nucleotide Metabolism - purine P14618 5315 15q23 human K270-sm 55435842 KNIKIISkIENHEGV PK intracellular localization; enzymatic activity, inhibited cell differentiation, inhibited PKM(INDUCES); AML1(INDUCES) 33473116 1 2 0 Sumoylation dissembled the tetrameric PKM2 to dimers in vitro and in leukemia cells (size-exclusion chromatography). induces nuclear localization, block of myeloid differentiation +Nol3 ARC Apoptosis; Nucleolus Q62881 85383 19q11 rat T149-p 448618 SEAVQPRtPEEPELE molecular association, regulation; intracellular localization; activity, inhibited apoptosis, inhibited CASP2(INDUCES) 12191471; 16639714; 19001025; 24106598 5 6 0 protects cells against oxidative stress; inhibition of hypertrophy; T149 phosphorylation promotes ARC localization to mitochondria, allowing ARC binding to Caspase-8.; T149D mutant inhibits apoptosis induced by isoproterenol or aldosterone +CLDN2 Claudin-2 Cytoskeletal; Membrane protein, integral; Membrane protein, multi-pass P57739 9075 Xq22.3 human Y224-p 462035 VKSEFNSySLTGYV_ molecular association, regulation ZO1(DISRUPTS) 26023235 1 0 3 disruption of barrier function +VCP VCP Chaperone; DNA repair, damage; EC 3.6.4.6; Endoplasmic reticulum; Hydrolase P55072 7415 9p13.3 human T509-p 4271173 KFLKFGMtPSKGVLF molecular association, regulation; intracellular localization; phosphorylation cell cycle regulation OTUB1(INDUCES); CLN3(INDUCES) 29950310 1 11 8 Cdc48 in the stabilization of Cln3 in the nucleus, regulates G1-cyclin activity for cell cycle entry, enhanced pRB phosphorylation +FGF10 FGF10 Cell development/differentiation; Cytokine; Motility/polarity/chemotaxis; Secreted; Secreted, signal peptide O15520 2255 5p12 human T114-p 12063900 PYSILEItSVEIGVV FGF activity, induced; molecular association, regulation cell growth, altered FGFR2(NOT_REPORTED) 20036575 1 0 0 +CD1D CD1D Apoptosis; Cell surface; Lipid-binding; Membrane protein, integral P15813 912 1q23.1 human T322-p 14364502 FLLIVGFtSRFKRQT TM protein degradation; intracellular localization 20368272; 23710894 2 0 1 inhibits cell surface expression and antigen presentation; regulates CD1D targeting to lysosomes +CD44 CD44 Cell adhesion; Membrane protein, integral; Motility/polarity/chemotaxis; Receptor, misc. P16070 960 11p13 human S672-p 455524 AVCIAVNsRRRCGQK molecular association, regulation cytoskeletal reorganization Ezrin(INDUCES) 12032545 5 0 0 +NFKB2 NFkB-p100 DNA-binding; Oncoprotein; Transcription factor Q00653 4791 10q24.32 human S707-p 20804978 EPLCPLPsPPTSDSD protein degradation; molecular association, regulation; ubiquitination carcinogenesis, induced; cell growth, induced; apoptosis, inhibited; transcription, induced FBXW7(INDUCES) 22388891; 22864569 2 2 0 +RAD51 RAD51 DNA repair, damage; Mitochondrial Q06609 5888 15q15.1 human K156-ac 1873284314 DRGGGEGkAMYIDTE Rad51 DNA repair, inhibited 28869605 1 0 0 +ATF6 ATF6A Membrane protein, integral; Transcription factor P18850 22926 1q23.3 human K152-ub 1881440801 AEPLKEDkPVTGPRN signaling pathway regulation 34623328 1 0 0 K152 ATF6 is required for PRR-induced, RNF186-dependent antimicrobial pathways in human MDMs +SAMHD1 SAMHD1 EC 3.1.4.- Q9Y3Z3 25939 20q11.23 human T592-p 468674 DVIAPLItPQKKEWN molecular association, regulation; intracellular localization; enzymatic activity, inhibited; protein conformation; enzymatic activity, induced cell cycle regulation; cell growth, inhibited SAMHD1(DISRUPTS) DNA(INDUCES) 28956603; 34321470; 34379507; 34513928; 35801923; 37127613 22 61 5 +PACS2 PACS2 Q86VP3 23241 14q32.33 human S437-p 480160 GRRGRSTsLKERQAA chromatin organization, altered 23852728 1 2 8 mitochondria-associated ER membrane integrity +INSR INSR EC 2.7.10.1; KINASE; Kinase, protein; Membrane protein, integral; Protein kinase, TK; Protein kinase, tyrosine (receptor) P06213 3643 19p13.2 human Y1011-p 449048 DVFPCSVyVPDEWEV enzymatic activity, inhibited 12707268 5 0 2 +SPEN SHARP Nuclear receptor co-regulator; RNA-binding; Spliceosome; Transcription factor Q96T58 23013 1p36.21-p36.13 human S3486-p 455623 QPAPKQDsSPHLTSQ transcription, altered 15824732 1 2 0 +Usf1 USF1 DNA-binding; Transcription factor Q61069 22278 1 H3|1 79.4 cM mouse S309-p 40515061 EVVIKNDsN______ molecular association, regulation transcription, inhibited DNA(DISRUPTS) 36534975 1 5 0 +SIK2 QIK EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, CAMK; Protein kinase, Ser/Thr (non-receptor) Q9H0K1 23235 11q23.1 human S343-p 2150903 RLKSHRSsFPVEQRL enzymatic activity, induced 27478041 3 6 4 +FUS hnRNP P2 DNA-binding; Nuclear receptor co-regulator; Oncoprotein; RNA splicing; RNA-binding; SUMO LIGASE P35637 2521 16p11.2 human R514-me 1873356110 GPGKMDSrGEHRQDR intracellular localization KPNB2(DISRUPTS) 22968170 1 0 0 Arginines in the RGG3 domain are required for nuclear import of mutant hnRNP, and arginine methylation in this domain reduces KPNB2 binding. +Zic2 ZIC2 C2H2-type zinc finger protein; DNA-binding Q62520 22772 14 E5|14 65.97 cM mouse S200-p 1783002 EQYRQVAsPRTDPYS activity, induced; molecular association, regulation transcription, altered DDX9(INDUCES) 18068128 1 1 0 +Stmn1 STMN1 Cytoskeletal P54227 16765 4 D3|4 66.76 cM mouse S16-p 448554 KELEKRAsGQAFELI Stathmin protein stabilization carcinogenesis, induced; cell motility, induced; cell growth, induced; apoptosis, induced; cytoskeletal reorganization; signaling pathway regulation 21646391; 32251425; 36484700 38 98 61 +PCLAF PAF DNA repair, damage Q15004 9768 15q22.31 human K24-ub 9187086 VAARAPRkVLGSSTS PAF DNA repair, altered 23000965 1 12 112 +CBX4 CBX4 EC 6.3.2.-; SUMO LIGASE; SUMO conjugating system; SUMO ligase; Transcription, coactivator/corepressor O00257 8535 17q25.3 human K280-ub 573756668 GMQAVKIkSGEVAEG protein degradation 32111827 1 1 0 +RAPH1 RAPH1 Adaptor/scaffold; Motility/polarity/chemotaxis Q70E73 65059 2q33.2 human S1066-p 23137493 DSVVEFPsPPSDSDF intracellular localization cell motility, induced VASP(DISRUPTS) 37632751 1 1 1 regulates MENA localization +PPP1R14B PPP1R14B Inhibitor; Protein phosphatase, regulatory subunit Q96C90 26472 11q13.1 human T57-p 1904503 VRRQGKVtVKYDRKE PP1_inhibitor activity, induced; activity, inhibited cell motility, altered 10606530; 12144526 4 4 1 inhibition of MLCP activity, activates contractile response in arterial smooth muscle; required for full inhibition of PP1CA in vitro. +RUBCNL RUBCNL Q9H714 80183 13q14.13 human S157-p 25284922 SPGILATsPYPETDS molecular association, regulation; acetylation; intracellular localization autophagy, inhibited; signaling pathway regulation VPS39(DISRUPTS); STX17(DISRUPTS); VPS41(DISRUPTS); Tip60(DISRUPTS) 30704899 1 0 1 phosphorylation of this site inhibits acetylation of RUBCNL sites K483, K523, K533, K573, K633, by inhibiting the GSK3/TIP60 signaling pathway +Eef1a1 EEF1A1 Nucleolus; Translation; Translation elongation P62630 171361 8q31 rat K165-m3 15382301 TEPPYSQkRYEEIVK GTP_EFTU molecular association, regulation translation, altered EEF1D(DISRUPTS); eEF1B(DISRUPTS); EEF1G(DISRUPTS) 28108655 1 3 3 +ANXA2 ANXA2 Calcium-binding; Lipid-binding; Motility/polarity/chemotaxis P07355 302 15q22.2 human T19-p 469172 SLEGDHStPPSAYGS intracellular localization 20597553 1 28 30 +ESPL1 separase EC 3.4.22.49; Protease Q14674 9700 12q13.13 human S1660-p 1269647504 ADQLQGLsLQEMPGD molecular association, regulation; phosphorylation cell cycle regulation; DNA repair, induced H2AX(INDUCES) 30305303 1 0 0 NES phosphorylation +TFRC TfR Cell surface; Membrane protein, integral; Receptor, misc. P02786 7037 3q29 human Y20-p 448928 FGGEPLSyTRFSLAR receptor internalization, induced endocytosis, induced; carcinogenesis, induced; cell growth, induced; apoptosis, inhibited 21859709; 35338344 2 43 1048 +Kit Kit EC 2.7.10.1; KINASE; Kinase, protein; Membrane protein, integral; Oncoprotein; Protein kinase, TK; Protein kinase, tyrosine (receptor) P05532 16590 5 C3.3|5 39.55 cM mouse Y732-p 454941 DMKPGVSyVVPTKTD PK_Tyr_Ser-Thr activity, induced; phosphorylation cell cycle regulation; cell growth, altered 11090054 1 4 28 promotes PLCg1 phosphorylation and Ca(2+) mobilization +CDK5RAP2 CDK5RAP2 Cytoskeletal Q96SN8 55755 9q33.2 human S140-p 41694200 SLAEAGGsEIQRVKE molecular association, regulation cytoskeletal reorganization TUBG1(INDUCES) 26192437 1 0 0 +MAPK15 ERK7 EC 2.7.11.24; KINASE; Kinase, protein; Protein kinase, CMGC; Protein kinase, Ser/Thr (non-receptor) Q8TD08 225689 8q24.3 human T175-p 459216 GPEDQAVtEYVATRW Pkinase enzymatic activity, induced apoptosis, induced 16336213; 16484222; 28467781 3 2 0 +Bmp4 BMP4 Secreted; Secreted, signal peptide P21275 12159 14 C1|14 23.95 cM mouse S91-p 1874396400 RDLYRLQsGEEEEEE TGFb_propeptide protein stabilization carcinogenesis, induced; cell differentiation, induced; transcription, induced 34433585 1 0 0 prevent lysosomal degradation of the protein BMP4 +Foxp3 FOXP3 C2H2-type zinc finger protein; Cell cycle regulation; DNA-binding; Transcription factor Q99JB6 20371 X A1.1|X 3.41 cM mouse S19-p 12201088 PSLALGPsPGVLPSW protein degradation cell growth, induced; transcription, altered 23853094 1 1 0 alanine mutants of S19 or T175 inhibited (lL2) or induced (CD25) transcription of FOXP3 responsive genes, suppressed T cell proliferation, and showed an anti-inflamatory effect in a murine colitis model +GLS glutaminase Amino Acid Metabolism - alanine, aspartate and glutamate; Amino Acid Metabolism - arginine and proline; EC 3.5.1.2; Energy Metabolism - nitrogen; Hydrolase; Mitochondrial; Other Amino Acids Metabolism - D-Glutamine and D-glutamate O94925 2744 2q32.2 human S95-p 36122852 THPQPGVsPPAAPAA enzymatic activity, inhibited cell growth, inhibited; cell motility, inhibited 30092248 1 3 0 decreases vimentin levels +PKD2 PKD2 Channel, cation; Membrane protein, integral; Membrane protein, multi-pass Q13563 5311 4q22.1 human S76-p 460685 AGAAASPsPPLSSCS intracellular localization 16551655 1 5 0 +Arhgef7 ARHGEF7 GEF; GEF, Rac/Rho; Motility/polarity/chemotaxis Q9ES28 54126 8|8 A1.1 mouse S682-p 455681 EEFAVRKsTAALEED RhoGEF67_u2 intracellular localization 12226077 3 19 2 +Mst1r Ron EC 2.7.10.1; KINASE; Kinase, protein; Membrane protein, integral; Protein kinase, TK; Protein kinase, tyrosine (receptor) Q62190 19882 9 59.07 cM|9 F1 mouse Y1175-p 456482 QVACGMEyLAEQKFV PK_Tyr_Ser-Thr enzymatic activity, induced Src(NOT_REPORTED) 16103119 2 0 0 this site is responsible for constitutive activation of the MAP kinase pathway +Tdg TDG DNA repair, damage; EC 3.2.2.29; Hydrolase; Nuclear receptor co-regulator P56581 21665 10 C1|10 39.72 cM mouse K98-ac 458996 ATSKKSGkSTKSKEK molecular association, regulation; acetylation; phosphorylation DNA repair, induced; chromatin organization, altered; DNA repair, inhibited; transcription, induced APE1(DISRUPTS) DNA(DISRUPTS) 11864601; 19966277 2 1 0 inhibits phosphorylation at other sites; histone acetylation +orf1ab nsp6-pp1a-pp1ab NP_828864 1489680 SARSCoV1 K61-ub 1883544401 ACAMLLVkHKHAFLC molecular association, regulation; intracellular localization TAK1(INDUCES); IKKG(INDUCES) 35856559 1 0 0 Accessory protein 7a and | nsp6-pp1a-pp1ab ubiquitiylation are required for the recruitment of NEMO and TAK1 to ORF7a and required for NF-kB activation. +Scn2a SCN2A Channel, sodium; Membrane protein, integral; Membrane protein, multi-pass P04775 24766 3q21 rat S1506-p 2999207 NAMKKLGsKKPQKPI activity, inhibited 12359152 1 0 0 +Dnmt1 DNMT1 Amino Acid Metabolism - cysteine and methionine; Cell development/differentiation; EC 2.1.1.37; METHYLTRANSFERASE; Methyltransferase; Methyltransferase, DNA; Transcription regulation P13864 13433 9 A3|9 7.66 cM mouse S515-p 458936 MQEKIYIsKIVVEFL DNMT1-RFD protein conformation; enzymatic activity, induced 17965600 2 2 0 important for an interaction between the N-terminal and the catalytic domain of DNMT1 +NFATC1 NFAT2 DNA-binding; Transcription factor O95644 4772 18q23 human S403-p 41453279 WAKPKPLsPTSYMSP protein stabilization 28235034 1 1 0 +MTMR2 MTMR2 Carbohydrate Metabolism - fructose and mannose; Cofactor and Vitamin Metabolism - riboflavin; Cofactor and Vitamin Metabolism - thiamine; EC 3.1.3.64; EC 3.1.3.95; Motility/polarity/chemotaxis; PHOSPHATASE; Phosphatase, lipid; Protein phosphatase, tyrosine (non-receptor) Q13614 8898 11q21 human S631-p 2526091 SSSERASsPAQCVTP molecular association, regulation; intracellular localization RAB5A(INDUCES); APPL(DISRUPTS) 23378027 1 12 0 inhibits binding and targting to early endosomes, regulates endosomal shuttling +PRKAA1 AMPKA1 Autophagy; EC 2.7.11.1; EC 2.7.11.26; EC 2.7.11.27; EC 2.7.11.31; KINASE; Kinase, protein; Protein kinase, CAMK; Protein kinase, Ser/Thr (non-receptor) Q13131 5562 5p13.1 human K485-ub 21128826 DDEITEAkSGTATPQ AdenylateSensor enzymatic activity, inhibited 31996460 1 5 0 +XPO1 Exportin-1 Karyopherin; Nuclear export; Nuclear import; Nucleolus O14980 7514 2p15 human S391-p 3174716 SPFSTSAsPLLSGSQ molecular association, regulation; intracellular localization cell cycle regulation; cytoskeletal reorganization RAN(INDUCES) 23729730 1 15 3 +FYB2 ARAP Adaptor/scaffold Q5VWT5 199920 1p32.2 human Y521-p 56614901 SEENRELyEDVYKTK intracellular localization signaling pathway regulation 27335501 1 0 0 +FGFR4 FGFR4 EC 2.7.10.1; KINASE; Kinase, protein; Membrane protein, integral; Protein kinase, TK; Protein kinase, tyrosine (receptor) P22455 2264 5q35.2 human Y642-p 461988 RGVHHIDyYKKTSNG PK_Tyr_Ser-Thr carcinogenesis, induced; cell growth, induced 34163030 1 9 51 +ACE2 ACE2 EC 3.4.17.23; Membrane protein, integral; Protease Q9BYF1 59272 Xp22.2 human S680-p 1868162500 ANLKPRIsFNFFVTA Collectrin protein conformation 37292255 3 0 0 induces conformational changes in all types of SARS-CoV-2 +Id1 ID1 DNA-binding; Transcription, coactivator/corepressor P20067 15901 2 H1|2 75.41 cM mouse S5-p 479430 ___MKVAsGSAAAAA intracellular localization 17412691 1 0 0 forskolin-induced nuclear localization +WWC1 KIBRA Adaptor/scaffold Q8IX03 23286 5q34 human S542-p 25673102 SPRSSLSsPSPPCSP cell cycle regulation; cell growth, induced 22784093; 24269383 2 0 0 +POLH POLH DNA repair, damage; EC 2.7.7.7; Transferase Q9Y253 5429 6p21.1 human S601-p 18330800 EMDLAHNsQSMHASS cell cycle regulation 21242293 2 1 1 influences cell survival +DOCK2 DOCK2 Adaptor/scaffold; GAP; GAP, Rac/Rho; Motility/polarity/chemotaxis Q92608 1794 5q35.1 human Y985-p 1876205000 DLIGKNVyPGDWMAM molecular association, regulation; intracellular localization; enzymatic activity, induced transcription, induced; signaling pathway regulation RAC1(INDUCES) 35079145 1 1 0 induces RAC1 GTPase recruitment and activation further inducing CLR signaling +DBF4 DBF4 Cell cycle regulation; Protein kinase, regulatory subunit Q9UBU7 10926 7q21.12 human S539-p 482262 GLITINSsQEHLTVQ cell cycle regulation 22123827 1 1 0 DBF4 phosphorylaion is important for supressing DNA replication. +GRIA4 GluR4 Channel, ligand-gated; Membrane protein, integral; Membrane protein, multi-pass P48058 2893 11q22.3 human S862-p 448810 IRNKARLsITGSVGE molecular association, regulation ACTN1(DISRUPTS) 16190873 6 4 1 Phosphorylation alters GluR4 binding to alpha-actinin in vitro and in vivo, but has no affect on IQGAP1 binding. +TOB2 TOB2 Q14106 10766 22q13.2 human S153-p 22999103 QDSSLSNsPSPSFGQ cell growth, inhibited 22252318 1 1 0 promote mRNA deadenylaion and decay and the ability to suppress proliferation +PRKCA PKCA EC 2.7.11.13; KINASE; Kinase, protein; Oncoprotein; Protein kinase, AGC; Protein kinase, Ser/Thr (non-receptor) P04409 282001 cow T638-p 448685 TRGQPVLtPPDQLVI Pkinase_C phosphorylation; enzymatic activity, induced 8805373 22 15 2 prolongs activation kinetics (not activity itself) and protection from phosphatases +CDC25A CDC25A EC 3.1.3.48; Motility/polarity/chemotaxis; PHOSPHATASE; Protein phosphatase, dual-specificity P30304 993 3p21.31 human S156-p 1874397800 KKPVRPVsRGCLHSH M-inducer_phosp protein degradation; ubiquitination cell cycle regulation; apoptosis, inhibited 34363019 1 1 0 +MYOD1 MyoD DNA-binding; RNA splicing; Transcription factor P15172 4654 11p15.1 human K104-ac 459081 ACKACKRkTTNADRR Basic molecular association, regulation; protein conformation cell differentiation, induced; transcription, induced DNA(INDUCES) 10619020 1 0 0 +Pea15 PEA-15 Apoptosis; Motility/polarity/chemotaxis Q62048 18611 1 H3|1 79.54 cM mouse S104-p 455750 TKLTRIPsAKKYKDI molecular association, regulation cell cycle regulation ERK1(DISRUPTS); ERK2(DISRUPTS) 15917297 13 27 322 +BTK Btk EC 2.7.10.2; KINASE; Kinase, protein; Protein kinase, TK; Protein kinase, tyrosine (non-receptor) Q06187 695 Xq22.1 human Y551-p 447486 RYVLDDEyTSSVGSK PK_Tyr_Ser-Thr activity, induced; molecular association, regulation; intracellular localization; enzymatic activity, induced signaling pathway regulation Hck(INDUCES); BLNK(INDUCES) 11226282; 11413148; 14597636; 17264076; 21482705; 21659545; 35639855; 37175486; 37197664; 8629002 34 14 136 Induce calcium signaling; regulates B cell receptor (BCR) signaling; Ca mobilization induced +Sqstm1 SQSTM1 Autophagy; Nuclear receptor co-regulator; Ubiquitin conjugating system Q64337 18412 11|11 B1.3 mouse T269-p 457004 GGKRSRLtPTTPESS cell cycle regulation; carcinogenesis, altered; transcription, induced; signaling pathway regulation 20974803; 33395605 9 74 136 Keap1-Nrf2 signaling; in Ras-transformed embryonic fibroblasts +SLC12A3 NCCT Membrane protein, integral; Membrane protein, multi-pass; Transporter; Transporter, SLC family P55017 6559 16q13 human T55-p 469616 SSTFCMRtFGYNTID AA_permease_N activity, induced; molecular association, regulation; protein conformation ADD3(DISRUPTS) 21164023; 36792826 25 3 0 +LDHA LDH-A Amino Acid Metabolism - cysteine and methionine; Apoptosis; Carbohydrate Metabolism - glycolysis and gluconeogenesis; Carbohydrate Metabolism - propanoate; Carbohydrate Metabolism - pyruvate; EC 1.1.1.27; Oxidoreductase P00338 3939 11p15.1 human Y10-p 454712 TLKDQLIyNLLKEEQ molecular association, regulation; protein conformation; enzymatic activity, induced carcinogenesis, induced; cell motility, induced; apoptosis, induced; cell growth, induced; apoptosis, inhibited LDH-A(INDUCES) 21969607; 28122247; 28218905; 33572095; 34452627; 35115484; 35525866; 37507768 8 24 374 +SHOC2 SHOC2 Adaptor/scaffold; Protein phosphatase, regulatory subunit Q9UQ13 8036 10q25.2 human T71-p 34669125 VAFSVDNtIKRPNPA protein degradation; ubiquitination cell growth, inhibited; cell motility, inhibited 29383184 1 2 1 +Caly calcyon Membrane protein, integral P58821 192349 1q41 rat S169-p 25687501 MPAIWGNsYRAGKEE Calcyon molecular association, regulation signaling pathway regulation PSD-95(INDUCES) 22843680 1 0 0 inhibits D1DR signaling and surface levels +ICAM3 ICAM3 Cell adhesion; Immunoglobulin superfamily; Membrane protein, integral P32942 3385 19p13.2 human S518-p 451020 REHQRSGsYHVREES activity, induced; intracellular localization 11784723; 9268366 2 0 5 S518A mutation blocked interleukin-2 secretion, aggregation, and cell spreading +LIX1L LIX1L RNA-binding Q8IVB5 128077 1q21.1 human Y136-p 48963900 VPSNSPPyVCYVTLP LIX1 carcinogenesis, induced; cell growth, induced; apoptosis, inhibited 26310847 1 0 0 +Epha3 EphA3 EC 2.7.10.1; KINASE; Kinase, protein; Membrane protein, integral; Protein kinase, TK; Protein kinase, tyrosine (receptor) P29319 13837 16|16 C1.3 mouse Y779-p 448910 EDDPEAAyTTRGGKI PK_Tyr_Ser-Thr cell cycle regulation; carcinogenesis, altered; cell motility, altered 18515860; 20697431 3 33 700 +CD6 CD6 Cell surface; Membrane protein, integral P30203 923 11q12.2 human S480-p 28095001 PPPEDSDsGSDSDYE phosphorylation signaling pathway regulation 23711376 1 0 0 ERK1/2 phosphorylation, MAPK pathway activation +SLC12A4 KCC1 Membrane protein, integral; Membrane protein, multi-pass; Transporter; Transporter, SLC family Q9UP95 6560 16q22.1 human Y1056-p 3087800 NSEGDENyMEFLEVL SLC12 activity, inhibited 10942735 1 0 0 +Alk ALK EC 2.7.10.1; KINASE; Kinase, protein; Membrane protein, integral; Oncoprotein; Protein kinase, TK; Protein kinase, tyrosine (receptor) P97793 11682 17 E1.3|17 43.77 cM mouse Y1592-p 450381 CGNVNYGyQQQGLPL carcinogenesis, induced; transcription, induced 36602782 3 1 27 +TXK TXK EC 2.7.10.2; KINASE; Kinase, protein; Protein kinase, TK; Protein kinase, tyrosine (non-receptor) P42681 7294 4p12 human Y91-p 2861416 KIQVKALyDFLPREP SH3_1 transcription, altered 12081135 2 2 0 +Hdac6 HDAC6 DEACETYLASE; Deacetylase; EC 3.5.1.98; Nuclear receptor co-regulator; Ubiquitin conjugating system Q9Z2V5 15185 X A1.1|X 3.58 cM mouse S59-p 4759169 KGKMKKLsQPAEEDL protein degradation; ubiquitination cytoskeletal reorganization 37450577 1 6 0 +H2BC3 H2B DNA-binding P33778 3018 6p22.2 human S32-p 447801 DGKKRKRsRKESYSI Histone cell growth, induced; translation, induced 21646345 7 0 0 transformation +PPP1R3B PPP1R3B Protein phosphatase, regulatory subunit Q86XI6 79660 8p23.1 human Y285-p 1065300 YEKLGPYy_______ molecular association, regulation PYGM(INDUCES) 17870073 1 0 0 +TIAM1 TIAM1 GEF; GEF, Rac/Rho; Motility/polarity/chemotaxis; Oncoprotein Q13009 7074 21q22.11 human S334-p 35524908 EGSEFADsGIEGATT protein degradation; molecular association, regulation BTRC(INDUCES) 25124033 1 1 0 +Ulk1 ULK1 Autophagy; EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, Other; Protein kinase, Ser/Thr (non-receptor) O70405 22241 5|5 F mouse T635-gl 231166705 PSFDFPKtPSSQNLL molecular association, regulation AMPKA1(INDUCES) 28903979 1 0 0 +Clip1 Restin Cytoskeletal Q9JK25 65201 12q16 rat S311-p 4769833 ASLKRSPsASSLSSM molecular association, regulation; protein conformation TUBA1C(DISRUPTS) 20519438 4 13 1 +Mtor mTOR Autophagy; EC 2.7.11.1; KINASE; Kinase, protein; Motility/polarity/chemotaxis; Protein kinase, Ser/Thr (non-receptor); Protein kinase, atypical P42346 56718 5q36 rat S2448-p 447578 RSRTRTDsYSAGQSV translation, altered 11884412 218 18 106 +KCNMB4 KCNMB4 Channel, potassium; Membrane protein, integral; Membrane protein, multi-pass Q86W47 27345 12q15 human S17-p 451269 YTEAEDKsIRLGLFL CaKB activity, inhibited 11790768 1 0 0 regulates slowpoke K(+) channel kinetics +MORC3 MORC3 Cell cycle regulation; RNA-binding Q14149 23515 21q22.12 human K651-sm 14988618 VPSLVVKkEETVEDE molecular association, regulation PML(INDUCES) 20501696 1 1 0 +TLE1 TLE1 Nuclear receptor co-regulator; Transcription, coactivator/corepressor Q04724 7088 9q21.32 human S253-p 23940705 DNLVVDVsNEDPSSP apoptosis, inhibited 22354967 1 2 0 +KRT18 K18 Cytoskeletal; Nucleolus P05783 3875 12q13.13 human K207-sm 25027602 ETEIEALkEELLFMK Filament cytoskeletal reorganization 21062750 1 0 0 sumoylation regulate solubility; modified by poly-SUMO-2/3 chains, oxidative stress, apoptosis, and/or phosphatase inhibition increase sumoylation in primary hepatocytes; K to R mutants show filament disorganization +CD300LF IREM-1 Immunoglobulin superfamily; Membrane protein, integral; Receptor, misc. Q8TDQ1 146722 17q25.1 human T221-p 1868016201 GTSPQKAtTKLSSAQ SIT signaling pathway regulation 32152116 1 0 0 +WASF2 WAVE2 Actin-binding; Motility/polarity/chemotaxis Q9Y6W5 10163 1p36.11 human Y150-p 455197 GKEALKFyTDPSYFF molecular association, regulation; intracellular localization cytoskeletal reorganization Abi-1(INDUCES) 15657136 3 0 0 +BRD4 BRD4 KINASE; Kinase, protein; Protein kinase, Ser/Thr (non-receptor); Protein kinase, atypical O60885 23476 19p13.12 human Y97-p 1874101902 VKLNLPDyYKIIKTP Bromodomain protein stabilization; molecular association, regulation; ubiquitination carcinogenesis, induced; chromatin organization, altered; transcription, induced BET1(DISRUPTS); STAT3(INDUCES); UCHL3(INDUCES) DNA(INDUCES) 34290255 1 1 0 inhibits ubiquitination +Irs2 IRS2 Adaptor/scaffold; Motility/polarity/chemotaxis F1MAL5 29376 16q12.5 rat S574-p 483923 GLRKRTYsLTTPARQ molecular association, regulation; phosphorylation 14-3-3 beta(INDUCES) 22912850 2 40 11 negatively regulates IGF-1/insulin signaling +Add2 ADD2 Cytoskeletal; Motility/polarity/chemotaxis Q05764 24171 4q34 rat S692-p 454590 SVTSGPLsPEGSPSK cytoskeletal reorganization 21606488 1 16 0 +G3BP1 G3BP-1 Adaptor/scaffold; EC 3.6.4.12; EC 3.6.4.13; Helicase; RNA-binding Q13283 10146 5q33.1 human K376-ac 466023 LRINSGGkLPNFGFV RRM_1 molecular association, regulation PABP 1(DISRUPTS) RNA(DISRUPTS) 31481451 1 5 6 K376 acetylation led to SG disassembly +Pik3r1 PIK3R1 KINASE; Kinase, lipid; Motility/polarity/chemotaxis P26450 18708 13 D1|13 53.92 cM mouse S690-p 25018700 EPYNLYSsLKELVLH SH2 molecular association, regulation; intracellular localization; phosphorylation signaling pathway regulation GAB1(DISRUPTS); IRS1(DISRUPTS) 22342344 1 1 0 inhibits AKT phosphorylation therefore it regulates PI3K/AKT and mTOR/S6 signaling pathway +Kcnb1 Kv2.1 Channel, cation; Channel, ligand-gated; Channel, potassium; Membrane protein, integral; Membrane protein, multi-pass P15387 25736 3q42 rat S541-p 473556 SKMAKTQsQPILNTK Kv2channel activity, inhibited 16917065 3 7 0 +PRDX2 PRDX2 EC 1.11.1.15; Oxidoreductase P32119 7001 19p13.13 human S76-p 1869663300 GCEVLGVsVDSQFTH AhpC-TSA molecular association, regulation PRDX2(DISRUPTS) 32601209 1 0 0 +ATM ATM DNA repair, damage; EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, Ser/Thr (non-receptor); Protein kinase, atypical; Tumor suppressor Q13315 472 11q22.3 human S1987-p 62382603 GSQSTTIsSLSEKSK enzymatic activity, inhibited; protein conformation cell cycle regulation; apoptosis, inhibited 27939942 2 0 0 +Arhgef7 ARHGEF7 GEF; GEF, Rac/Rho; Motility/polarity/chemotaxis Q9ES28 54126 8|8 A1.1 mouse T683-p 455216 EFAVRKStAALEEDA RhoGEF67_u2 intracellular localization 12226077 7 6 1 +Ahcyl1 AHCYL1 Amino Acid Metabolism - cysteine and methionine; EC 3.3.1.1; Hydrolase; Other Amino Acids Metabolism - selenoamino acid Q80SW1 229709 3 F2.3|3 46.83 cM mouse S66-p 50680601 GRRSLSRsISQSSTD molecular association, regulation PIP5K1A(INDUCES) 26509711 1 0 0 +Sharpin SHARPIN Apoptosis Q91WA6 106025 15 D3|15 35.75 cM mouse K168-ub 54221301 PQSSGNFkKEELATR signaling pathway regulation 26829767 1 1 0 regulation of TCR signaling-maintenance of immuno; ogical signaling K63-linked polyubiquitination +Prkd1 PRKD1 Autophagy; EC 2.7.11.13; KINASE; Kinase, protein; Motility/polarity/chemotaxis; Protein kinase, CAMK; Protein kinase, Ser/Thr (non-receptor) Q9WTQ1 85421 6q22 rat S203-p 449896 GVRRRRLsNVSLTGL intracellular localization 28408623 8 36 86 translocation from the membrane to the interior of the cell +PREX2 PREX2 GEF; GEF, Rac/Rho; Phosphatase, regulatory subunit Q70Z35 80243 8q13.2 human S1107-p 35483225 DTISNRDsYSDCNSN intracellular localization; activity, inhibited 26438819 1 0 0 +SMAD3 SMAD3 DNA-binding; Nuclear receptor co-regulator; Transcription factor P84022 4088 15q22.33 human T8-p 452179 MSSILPFtPPIVKRL cell cycle regulation; transcription, inhibited; transcription, altered 15241418; 20736297 5 13 0 +SRC Src EC 2.7.10.2; KINASE; Kinase, protein; Oncoprotein; Protein kinase, TK; Protein kinase, tyrosine (non-receptor) P12931 6714 20q11.23 human Y419-p 448234 RLIEDNEyTARQGAK PK_Tyr_Ser-Thr activity, induced; molecular association, regulation; intracellular localization; phosphorylation; enzymatic activity, induced cell cycle regulation; carcinogenesis, induced; cell motility, induced; cell adhesion, induced; cell motility, inhibited; cell adhesion, inhibited; signaling pathway regulation; RNA splicing, induced; cell growth, induced; cell motility, altered; cell growth, altered; cell differentiation, inhibited; carcinogenesis, inhibited; carcinogenesis, altered; transcription, induced; transcription, altered; apoptosis, inhibited; cytoskeletal reorganization; cell adhesion, altered ITGB3(INDUCES); Cbl-c(INDUCES); SHPS1(INDUCES); DOR-1(INDUCES); FBXL7(INDUCES) 11600431; 11804588; 12052863; 12473651; 14661060; 14720123; 15899872; 18454177; 19014372; 20129247; 20211239; 20501847; 21442427; 21873224; 21878628; 23471971; 23612968; 23644655; 24632852; 25947380; 26918609; 27101103; 30095367; 30664792; 31619538; 31973024; 32002121; 32539222; 32839549; 33761359; 33903122; 34088769; 34148056; 34226698; 34240802; 34335982; 34375550; 34532864; 34588619; 34642304; 34856074; 35131384; 35257717; 35297710; 35697802; 35713503; 35773413; 35810308; 35830815; 35948987; 35999654; 36268559; 36319849; 36443287; 36862682; 37330581; 37402225; 9271228 447 103 3046 +CAMK2G CAMK2G EC 2.7.11.17; KINASE; Kinase, protein; Protein kinase, CAMK; Protein kinase, Ser/Thr (non-receptor) Q13555 818 10q22.2 human S26-p 455247 ELGKGAFsVVRRCVK Pkinase enzymatic activity, inhibited; phosphorylation 23289753 1 3 0 phosphorylation works as an internal break, switching off the constitutively active oligomeric CaMKII.; decreases T287 autophosphorylation +NF1 NF1 iso2 GAP; GAP, Ras; Motility/polarity/chemotaxis; Nucleolus; Tumor suppressor P21359-2 4763 17q11.2 human T2554-p 456019 KMRRVAEtDYEMETQ molecular association, regulation; activity, inhibited 14-3-3 beta(INDUCES) 14741381 1 1 0 +Prkd1 PRKD1 Autophagy; EC 2.7.11.13; KINASE; Kinase, protein; Motility/polarity/chemotaxis; Protein kinase, CAMK; Protein kinase, Ser/Thr (non-receptor) Q62101 18760 12|12 B3 mouse Y469-p 448648 NDTGSRYyKEIPLSE PH enzymatic activity, induced 15084589 7 0 0 +Sox9 SOX9 DNA-binding; Transcription factor Q04887 20682 11 E2|11 77.27 cM mouse S211-p 450957 FKALQADsPHSSSGM activity, induced transcription, altered 19113914 2 1 0 promotes expression of osteochondrogenic markers +Myocd myocardin Cell development/differentiation; Transcription factor Q8VIM5 214384 11|11 B3 mouse S866-p 10791201 SPMHAQLsPPSVDSS molecular association, regulation transcription, inhibited CBP(DISRUPTS) 19776005 1 0 0 +MDC1 MDC1 Cell cycle regulation Q14676 9656 6p21.33 human K1840-sm 55434044 SQKTVIIkEEEEDTA protein degradation; molecular association, regulation; ubiquitination DNA repair, induced; DNA repair, altered CtIP(INDUCES); RAD51(INDUCES) 22635276; 28275011; 30796017 3 3 0 recruitment of ataxin-3 to DSBs is dependent on SUMOylation; SENP2 regulates MDC1 SUMOylation DSB repair responses +MCM3 MCM3 DNA replication; EC 3.6.4.12 P25205 4172 6p12.2 human K351-ub 21178624 IGDPSVAkSQLLRYV MCM cell cycle regulation 27621311 1 4 0 KEAP1-MCM3 associates with chromatin in a cell cycle-dependent manner +Epha8 EphA8 EC 2.7.10.1; KINASE; Kinase, protein; Membrane protein, integral; Protein kinase, TK; Protein kinase, tyrosine (receptor) O09127 13842 4|4 D3 mouse Y615-p 448558 FSAEPHTyEEPGRAG EphA2_TM molecular association, regulation cell adhesion, altered Fyn(INDUCES) 10498895 1 0 0 +LTB4R LTB4R GPCR, family 1; Membrane protein, integral; Membrane protein, multi-pass; Receptor, GPCR Q15722 1241 14q12 human S310-p 13310168 KLLEGTGsEASSTRR receptor internalization, induced cell motility, induced; signaling pathway regulation 22707565; 30131369 3 2 0 directionality of chemotaxis ; enhanced ligand-induced internalization ; chemotaxis, B-hexisaminidase release, regulates LTB4R function +PIAS1 PIAS1 EC 6.3.2.-; Nuclear receptor co-regulator; SUMO LIGASE; SUMO conjugating system; SUMO ligase; Transcription, coactivator/corepressor O75925 8554 15q23 human K117-sm 580826070 PVSLLGPkHELELPH protein degradation; ubiquitination; intracellular localization MDM2(INDUCES) 31620784; 31752909 2 2 0 sumoylated PIAS1/SUMO3 induced AR cytoplasmic translocation and subsequent ubiquitination-mediated degradation; AR caused by sumoylated PIAS1 to its proteasome-dependent degradation; MDM2 is recruited to induce AR degradation; cytoplasmic localization (K388), AR-PIAS1- or SUMO3-modified PIAS1 interactions, AR and sumoylated PIAS1 complex +PTPN6 SHP-1 EC 3.1.3.48; Motility/polarity/chemotaxis; PHOSPHATASE; Protein phosphatase, tyrosine (non-receptor) P29350 5777 12p13.31 human Y301-p 464270 SNIPGSDyINANYIK Y_phosphatase molecular association, regulation transcription, inhibited; signaling pathway regulation GRB2(INDUCES) 14551136 1 2 69 recruitment of Grb2 targets SOCS-1 to Jak2 +Ulk1 ULK1 Autophagy; EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, Other; Protein kinase, Ser/Thr (non-receptor) O70405 22241 5|5 F mouse T180-p 21041603 QSNMMAAtLCGSPMY Pkinase phosphorylation; enzymatic activity, induced carcinogenesis, induced; autophagy, induced; signaling pathway regulation 21819378; 35246531 2 0 0 +LASP1 Lasp-1 Actin-binding; Motility/polarity/chemotaxis Q14847 3927 17q12 human Y171-p 451675 IPTSAPVyQQPQQQP molecular association, regulation; intracellular localization; protein conformation; phosphorylation carcinogenesis, induced; apoptosis, induced; cell motility, altered CXCR4(DISRUPTS); CRKL(INDUCES); AGO2(INDUCES); Akt1(DISRUPTS) 15138294; 19718473; 24913448; 32075106; 32872485 5 9 426 important for cell spreading; inhibits phosphorylation at S146 +Grin2a NMDAR2A Channel, ligand-gated; Membrane protein, integral; Membrane protein, multi-pass Q00959 24409 10q11 rat S580-p 1871177709 VFVFEYFsPVGYNRN Lig_chan intracellular localization; activity, inhibited cell cycle regulation 33184446 1 0 0 +HMGN1 HMGN1 DNA-binding; Nuclear receptor co-regulator P05114 3150 21q22.2 human K31-ac 458846 LSAKPPAkVEAKPKK HMG14_17 molecular association, regulation DNA(DISRUPTS) 10753971 1 0 2 +GPRC5A RAIG1 GPCR, family 3; Membrane protein, integral; Membrane protein, multi-pass; Receptor, GPCR Q8NFJ5 9052 12p13.1 human Y347-p 450338 AHAWPSPyKDYEVKK cell growth, induced 25311788 1 24 826 Tyrosine phosphorylation inhibits the suppressive effect of RAIG1 on cell invasion and anchorage-independent growth. +CSNK1E CK1E EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, CK1; Protein kinase, Ser/Thr (non-receptor) P49674 1454 22q13.1 human T334-p 453418 ALPPGPPtGATANRL enzymatic activity, inhibited 10542239; 12223474 2 0 0 some subset of these 8 sites +Itgb3 ITGB3 Cell adhesion; Membrane protein, integral; Motility/polarity/chemotaxis O54890 16416 11 E1|11 67.84 cM mouse Y772-p 448012 DTANNPLyKEATSTF Integrin_b_cyt molecular association, regulation; protein processing; activity, inhibited SHC1(INDUCES); DOK1(INDUCES) 10964917; 16935858; 23983218 22 10 95 inhibits m-calpain cleavage; inhibits beta 3 integrin signaling +MYL12A MRLC3 Contractile P19105 10627 18p11.31 human Y155-p 7382105 DKKGNFNyIEFTRIL EF-hand_11 molecular association, regulation; intracellular localization; protein conformation; phosphorylation cytoskeletal reorganization; cell motility, inhibited; cell adhesion, inhibited MYH2(DISRUPTS) 32502416 1 4 48 induces phosphorylation at the other sites +CYBA CYBA EC 1.-.-.-; Membrane protein, integral; Oxidoreductase P13498 1535 16q24.2 human T147-p 7103047 ERPQIGGtIKQPPSN Cytochrom_B558a molecular association, regulation; enzymatic activity, induced p47phox(INDUCES) 19948736 3 13 5 +Rac2 RAC2 G protein; G protein, monomeric; G protein, monomeric, Rho; Motility/polarity/chemotaxis Q05144 19354 15|15 E1 mouse K123-ub 12402500 KLDLRDDkDTIEKLK Ras protein degradation; molecular association, regulation; ubiquitination ALDH2(INDUCES) 35354308 1 7 2 rs671 mutation had significantly lower efferocytotic ability compared with wild-type, ALDH2 WT interacted with RAC2 and stabilized it by inhibited K48-linked polyubiquitination at K123. +INSR INSR EC 2.7.10.1; KINASE; Kinase, protein; Membrane protein, integral; Protein kinase, TK; Protein kinase, tyrosine (receptor) P06213 3643 19p13.2 human Y1185-p 447680 FGMTRDIyETDYYRK PK_Tyr_Ser-Thr molecular association, regulation; receptor internalization, altered; enzymatic activity, induced signaling pathway regulation IRS2(INDUCES); APS(INDUCES); PTP1B(INDUCES) 10852715; 12917346; 14690593; 1658004; 22081023; 8024702; 8999839; 9195949 38 31 455 morphine-inhibited insulin receptor signaling +Add3 ADD3 Cytoskeletal; Motility/polarity/chemotaxis Q62847 25230 1q55 rat S692-p 452158 KKKFRTPsFLKKNKK intracellular localization 9607561 2 56 164 +EFNB1 EFNB1 Ligand, receptor tyrosine kinase; Membrane protein, integral P98172 1947 Xq13.1 human Y317-p 448341 ENNYCPHyEKVSGDY cell adhesion, induced; signaling pathway regulation 16211011 2 17 189 +Nfatc4 NFAT3 DNA-binding; Transcription factor Q8K120 73181 14|14 C3 mouse S168-p 448859 QGGGAFFsPSPGSSS intracellular localization; activity, inhibited transcription, altered 18347059; 18691762; 27307045 7 0 1 +HSP90AA1 HSP90A Chaperone; Heat shock protein P07900 3320 14q32.31 human Y309-p 3798180 DDITNEEyGEFYKSL HSP90 protein conformation 23867252 1 1 3 phosphorylation induces altered conformation and governs drug specificity. +MICAL1 MICAL1 Adaptor/scaffold; EC 1.14.13.-; Motility/polarity/chemotaxis Q8TDZ2 64780 6q21 human S960-p 6226101 ELALRRQsSSPEQQK bMERB_dom molecular association, regulation cytoskeletal reorganization 14-3-3 epsilon(INDUCES); Rab7(INDUCES); RAB10(INDUCES) 36198272 1 2 7 +Nfatc2 NFAT1 DNA-binding; Transcription factor Q60591 18019 2 H3|2 88.91 cM mouse S219-p 447846 AHYSPRTsPIMSPRT protein stabilization; ubiquitination carcinogenesis, induced; cell growth, induced; transcription, induced; transcription, inhibited 11030334; 21628454 2 12 3 inhibits ubiquitination of NFAT1 residues K684 and K897 +BHLHE40 BHLHB2 Nucleolus; Transcription regulation O14503 8553 3p26.1 human S243-p 36324900 GSDTDTDsGYGGESE protein degradation cell cycle regulation 25202122 1 0 0 +WWC1 KIBRA Adaptor/scaffold Q8IX03 23286 5q34 human S931-p 3205620 IIRSKTFsPGPQSQY cell cycle regulation 22784093 1 5 1 +CENPA CENPA DNA-binding P49450 1058 2p23.3 human S7-p 448601 _MGPRRRsRKPEAPR Histone molecular association, regulation; intracellular localization cell cycle regulation; chromatin organization, altered AurA(INDUCES) 11756469; 14667408 18 0 0 Aurora B, INCEP and PP1gamma are mislocalized during anaphase in mitosis in mutants. ; S7A mutation causes defective kinetochore function and mislocalization of Aurora B. +TGM2 TGM2 EC 2.3.2.13; KINASE; Transferase P21980 7052 20q11.23 human S216-p 467223 RDCSRRSsPVYVGRV molecular association, regulation signaling pathway regulation 14-3-3 epsilon(INDUCES) 16870138; 22142843 3 4 2 activation of Akt-signaling pathway, downregulation of EGFR +Ncam1 NCAM1 Cell adhesion; Membrane protein, GPI anchor; Membrane protein, integral; Motility/polarity/chemotaxis P13596 24586 8q23 rat Y744-p 454070 VVMDITCyFLNKCGL cell growth, altered 20605779 2 0 0 +TSC2 TSC2 Cell cycle regulation; GAP; GAP, misc.; Nuclear receptor co-regulator; Tumor suppressor P49815 7249 16p13.3 human S1217-p 1868502602 MSLENPLsPFSSDIN activity, inhibited; phosphorylation cell cycle regulation; cell growth, induced; translation, induced 32294430 1 0 0 induces S6K phosphorylation +Cnr1 CNR1 GPCR, family 1; Membrane protein, integral; Membrane protein, multi-pass; Receptor, GPCR P47746 12801 4 A5|4 16.28 cM mouse S463-p 22342305 KIAKVTMsVSTDTSA receptor desensitization, induced 22014214 1 0 0 +NEK6 NEK6 EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, Other; Protein kinase, Ser/Thr (non-receptor) Q9HC98 10783 9q33.3 human Y108-p 12475501 NHPNIIKyLDSFIED Pkinase enzymatic activity, inhibited 19941817 1 0 0 +RPS6KB2 P70S6KB EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, AGC; Protein kinase, Ser/Thr (non-receptor); Translation Q9UBS0 6199 11q13.2 human S417-p 455990 SPRRLNSsPRAPVSP enzymatic activity, induced 11108720 2 10 11 +OSBP OSBP Lipid-binding P22059 5007 11q12.1 human S240-p 484804 TALQRSLsELESLKL activity, inhibited 21285358 2 45 16 +Gja1 GJA1 Channel, misc.; Membrane protein, integral; Membrane protein, multi-pass; Motility/polarity/chemotaxis P08050 24392 20q11 rat Y247-p 447814 VKGRSDPyHATTGPL activity, induced; molecular association, regulation; intracellular localization; activity, inhibited carcinogenesis, altered; cytoskeletal reorganization; cell growth, altered TUBB(DISRUPTS); PTPN2(INDUCES) 14681032; 16916748; 20676131; 24849651; 27235399; 27391443; 32956670 14 9 248 allows anchorage-independent growth; inhibits Src activity; disrupts gap junction communication; regulation of gap junction intercellular communication +KCNQ2 Kv7.2 Channel, potassium; Membrane protein, integral; Membrane protein, multi-pass O43526 3785 20q13.33 human S414-p 58948900 KDPPPEPsPSKGSPC activity, inhibited neural plasticity 36070693 1 2 0 +CFTR CFTR Channel, chloride; EC 3.6.3.49; Hydrolase; Membrane protein, integral; Membrane protein, multi-pass; Transporter; Transporter, ABC family P13569 1080 7q31.2 human S422-p 3333404 NNNNRKTsNGDDSLF activity, induced 21930781 4 3 0 +Mafb MAFB DNA-binding; Oncoprotein; Transcription factor; Tumor suppressor P54841 16658 2 H2|2 80.92 cM mouse K297-sm 12004403 ERDAYKVkCEKLANS bZIP_Maf cell differentiation, inhibited; cell cycle regulation; cell growth, induced; transcription, inhibited 17548468 1 0 0 +EP300 p300 ACETYLTRANSFERASE; Acetyltransferase; EC 2.3.1.48; Motility/polarity/chemotaxis; Nuclear receptor co-regulator; Transcription, coactivator/corepressor Q09472 2033 22q13.2 human S2039-p 31828207 GLGQVGIsPLKPGTV Creb_binding protein degradation; acetylation cell cycle regulation; carcinogenesis, induced; chromatin organization, altered; cell motility, induced; cell growth, induced; transcription, inhibited 24530506 1 0 0 Decrease histone H3-acetylation +MEF2C MEF2C DNA-binding; Transcription factor Q06413 4208 5q14.3 human K264-ac 12674409 VLIPPGSkNTMPSVS molecular association, regulation cell differentiation, induced; transcription, induced MRF(INDUCES) DNA(INDUCES) 15831463 1 0 0 +Syk Syk EC 2.7.10.2; KINASE; Kinase, protein; Protein kinase, TK; Protein kinase, tyrosine (non-receptor) P48025 20963 13 A5|13 27.41 cM mouse Y346-p 447660 TEVYESPyADPEEIR molecular association, regulation; enzymatic activity, inhibited; phosphorylation; enzymatic activity, induced endocytosis, altered; cell motility, altered; cell adhesion, altered; signaling pathway regulation FGR(INDUCES) 11672534; 12077122; 15536084; 15576379; 27609517; 37268160 38 22 248 Mutant Y342F/346F Syc showed less efficient FcERI-induced degranulation, and delayed calcium influx. ; inhibits phosphorylation of itself at Y342 and of LAT and PLCG2, thus inhibiting GPVI-mediated signaling; AKT phosphorylation +Aqp2 AQP2 Channel, misc.; Membrane protein, integral; Membrane protein, multi-pass; Transporter; Transporter, aquaporin family P34080 25386 7q36 rat S256-p 449854 REVRRRQsVELHSPQ activity, induced; molecular association, regulation; intracellular localization endocytosis, inhibited GDI2(DISRUPTS); HSP70(DISRUPTS); RAN(DISRUPTS); ANXA2(DISRUPTS); HSC70(DISRUPTS); GRP78(INDUCES); PPP1CA(DISRUPTS) 10653816; 10710543; 12897058; 15010357; 18434387; 19209902; 21148409; 22403603; 23559583; 24700872; 32113684; 32295252 78 9 0 +PDPK1 PDK1 EC 2.7.11.1; KINASE; Kinase, protein; Nuclear receptor co-regulator; Protein kinase, AGC; Protein kinase, Ser/Thr (non-receptor) O15530 5170 16p13.3 human S394-p 12729600 QVSSSSSsHSLSASD apoptosis, altered; cell growth, altered 19920149 2 0 0 +XPC XPC DNA repair, damage Q01831 7508 3p25.1 human S892-p 481830 DEEEGTSsQAEAARI DNA repair, inhibited 29660033 1 3 3 +TOP2A TOP2A EC 5.99.1.3; Isomerase P11388 7153 17q21.2 human S1365-p 18016961 TKTSPKLsNKELKPQ protein degradation; molecular association, regulation; ubiquitination; phosphorylation FBXW7(INDUCES) 21254166 1 3 0 +Slc1a2 GLT1 Membrane protein, integral; Membrane protein, multi-pass; Transporter; Transporter, SLC family P43006 20511 2 E2|2 54.13 cM mouse K549-ub 4667700 SVVIDECkVTLAANG molecular association, regulation GLT1(INDUCES) 35938532 2 0 0 formation of oligomers, epileptic seizures inhibited by APAP treatment +Numbl NUMBL Cell development/differentiation A1L1I3 292732 1q21 rat S305-p 456489 EQLVRQGsFRGFPAL NumbF molecular association, regulation 14-3-3 eta(INDUCES) 16105844 1 16 7 +OPTN optineurin Inhibitor Q96CV9 10133 10p13 human K501-ub 12313403 LQLAVLLkENDAFED CC2-LZ protein degradation autophagy, induced 32014991 1 1 42 required for proper proteostasis of DBR exposed SOD1 +E2F1 E2F1 DNA-binding; Transcription factor Q01094 1869 20q11.22 human K117-ac 459017 GRGRHPGkGVKSPGE protein stabilization; molecular association, regulation apoptosis, induced; transcription, induced DNA(INDUCES) 10675335; 10753885; 22184068 3 0 0 etoposide-induced DNA damage, pRB-free form of E2F1, does not bind to pRB; both complexes act in parallel to induce transcription of proapoptotic genes +MCM7 MCM7 DNA replication; EC 3.6.4.12; Motility/polarity/chemotaxis P33993 4176 7q22.1 human Y600-p 463418 WASKDATyTSARTLL MCM_lid molecular association, regulation cell cycle regulation; carcinogenesis, induced; cell growth, induced MCM2(INDUCES); MCM5(INDUCES); MCM3(INDUCES) DNA(INDUCES) 23764002 1 3 39 enhances binding at DNA replication origins +KAT5 Tip60 ACETYLTRANSFERASE; Acetyltransferase; EC 2.3.1.48; Nuclear receptor co-regulator; Nucleolus Q92993 10524 11q13.1 human Y44-p 28132103 ISGRKLFyVHYIDFN Tudor-knot molecular association, regulation; phosphorylation; enzymatic activity, induced cell cycle regulation; DNA repair, induced H3(INDUCES); AGO2(INDUCES) DNA(INDUCES) 23708966; 26822153 2 0 0 ATM autophosphorylation +DEPTOR DEPTOR Apoptosis Q8TB45 64798 8q24.12 human S258-p 8089037 QSHDNRKsTSFMSVS protein degradation; molecular association, regulation carcinogenesis, induced; apoptosis, inhibited; signaling pathway regulation mTOR(DISRUPTS) 19446321 1 2 1 PI3K-Akt signaling +MRE11 MRE11A Cell cycle regulation; DNA repair, damage; DNA-binding; Deoxyribonuclease P49959 4361 11q21 human T329-p 11506402 NPDNPKVtQAIQSFC Mre11_DNA_bind molecular association, regulation DNA(DISRUPTS) 19709933 1 0 0 +SMAD4 SMAD4 DNA-binding; Nuclear receptor co-regulator; Transcription, coactivator/corepressor Q13485 4089 18q21.2 human T197-p 1876808208 ASTETYStPALLAPS protein degradation; ubiquitination carcinogenesis, induced; cell motility, induced; cell growth, induced; transcription, induced 35437307 1 0 0 +F2R PAR1 Cell development/differentiation; GPCR, family 1; Membrane protein, integral; Membrane protein, multi-pass; Receptor, GPCR P25116 2149 5q13.3 human S399-p 3627502 SDPSSYNsSGQLMAS receptor desensitization, altered 10413505 1 1 1 receptor shutoff (not internalization) +Ncoa3 SRC-3 ACETYLTRANSFERASE; Acetyltransferase; EC 2.3.1.48; Motility/polarity/chemotaxis; Nuclear receptor co-regulator; Transcription, coactivator/corepressor O09000 17979 2|2 H3 mouse R1178-m2 2363405 TNTPKQLrMQLQQRL protein degradation transcription, inhibited CBP(INDUCES) 17043108 1 1 22 +Wasf2 WAVE2 Actin-binding; Motility/polarity/chemotaxis Q8BH43 242687 4 D2.3|4 66.22 cM mouse Y150-p 455197 GKEALKFyTNPSYFF cell motility, induced; cytoskeletal reorganization 16899465; 22617848 3 0 0 regulate multipolar-bipolar neuron transition and growth cone activities +AKT1 Akt1 EC 2.7.11.1; KINASE; Kinase, protein; Oncoprotein; Protein kinase, AGC; Protein kinase, Ser/Thr (non-receptor) P31749 207 14q32.33 human T312-p 5862771 TMKTFCGtPEYLAPE Pkinase enzymatic activity, inhibited signaling pathway regulation 23142783 1 2 5 AKT-mTOR pathway +PLD2 PLD2 EC 3.1.4.4; Lipid Metabolism - ether lipid; Lipid Metabolism - glycerophospholipid; Motility/polarity/chemotaxis; Phospholipase O14939 5338 17p13.2 human Y179-p 458807 RLLTMSFyRNYHAMT PX molecular association, regulation; enzymatic activity, induced; phosphorylation cell cycle regulation; cell motility, altered; cell growth, altered GRB2(INDUCES); CD45(DISRUPTS) 16407827; 18006275; 19715678; 20647543 4 0 0 +Htr2c 5-HT(2C) GPCR, family 1; Membrane protein, integral; Membrane protein, multi-pass; Receptor, GPCR P08909 25187 Xq34 rat S459-p 449971 VVSERISsV______ receptor desensitization, altered 10816555 2 0 0 +BCL6 Bcl-6 C2H2-type zinc finger protein; Oncoprotein; Transcription factor P41182 604 3q27.3 human S343-p 471422 KSDCQPNsPTESCSS protein degradation 9649500 2 6 19 +Gli2 GLI2 C2H2-type zinc finger protein; Oncoprotein; Transcription factor Q0VGT2 14633 1 E2.3|1 52.17 cM mouse S923-p 15410484 PLGPRRGsDGPTYSH sumoylation 22549777 2 1 3 +PML PML Nucleolus; Oncoprotein; SUMO LIGASE; SUMO conjugating system; SUMO ligase; Transcription factor; Tumor suppressor; Ubiquitin conjugating system P29590 5371 15q24.1 human K490-sm 2793913 QCPRKVIkMESEEGK DUF3583 protein degradation; molecular association, regulation; ubiquitination; intracellular localization cell differentiation, induced; transcription, induced PIAS1(INDUCES); SUMO1(INDUCES) 10779416; 17989716; 18408733; 19106612; 19380586; 20205709; 23542129; 27099310; 9756909; 9885291 15 6 0 +Frs2 FRS2 Adaptor/scaffold Q8C180 327826 10|10 D2 mouse Y306-p 449783 PPVNKLVyENINGLS molecular association, regulation GRB2(INDUCES) 9182757 3 14 216 +TRIM25 TRIM25 EC 6.3.2.19; EC 6.3.2.n3; Ligase; Nuclear receptor co-regulator; Transcription factor; UBIQUITIN LIGASE; Ubiquitin conjugating system; Ubiquitin ligase Q14258 7706 17q22 human S12-p 1868624700 CPLAEELsCSICLEP protein stabilization; molecular association, regulation; activity, inhibited carcinogenesis, induced; cell growth, induced; signaling pathway regulation TRIM25(DISRUPTS) 31186535 2 0 0 dimerization decreased in S12D mutant +ROCK2 ROCK2 EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, AGC; Protein kinase, Ser/Thr (non-receptor) Q28021 282041 cow S1374-p 468651 MKIQQNQsIRRPSRQ enzymatic activity, induced cell cycle regulation 17446864 2 21 1 alanine mutation of all 4 sites +Ikzf1 Ikaros C2H2-type zinc finger protein; DNA-binding; Transcription factor Q03267 22778 11 A1|11 7.02 cM mouse S13-p 4828300 GQDMSQVsGKESPPV molecular association, regulation; intracellular localization DNA(DISRUPTS) 18223295 1 0 0 +Ulk1 ULK1 Autophagy; EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, Other; Protein kinase, Ser/Thr (non-receptor) O70405 22241 5|5 F mouse S983-p 1869357209 TAERLILsHAVQMVQ DUF3543 cell cycle regulation; autophagy, induced; cell growth, induced 32516310 1 0 0 +Rb1 Rb Nuclear receptor co-regulator; Oncoprotein; Transcription, coactivator/corepressor; Tumor suppressor P13405 19645 14 38.73 cM|14 D3 mouse T246-p 449821 PINGSPRtPRRGQNR molecular association, regulation cell cycle regulation; cell growth, induced; transcription, inhibited E2F1(DISRUPTS) 10207050; 35023164; 9671466 21 23 68 transcriptional downregulation of the E2F-1, E2F-2, dihydrofolate reductase, thymidine kinase, c-myc, proliferating-cell nuclear antigen, p107, and p21/Cip1 genes +NEDD4L NEDD4L EC 6.3.2.-; EC 6.3.2.19; Ligase; UBIQUITIN LIGASE; Ubiquitin conjugating system; Ubiquitin ligase Q96PU5 23327 18q21.31 human S795-p 18963100 VDLKPNGsEIMVTNE HECT enzymatic activity, induced 21501591 1 0 0 regulates Kir2.1 expression at cell membrane +MAVS MAVS Adaptor/scaffold; Membrane protein, integral Q7Z434 57506 20p13 human Y9-p 25687502 PFAEDKTyKYICRNF CARD_2 protein degradation; molecular association, regulation autophagy, induced; transcription, induced; signaling pathway regulation TRAF3(INDUCES); LC3A(INDUCES); TRAF6(INDUCES) 22844514; 28141795 2 0 0 NF-kB-dependent transcription ; RIG-I-mediated IFN-beta signaling; phosphorylation of MAVS at Y9 enhances phosphorylation of IRF3; IFN-B promoter activation, MPTP induced microglial activation and neurotoxicity +MPL MPL Membrane protein, integral; Receptor, cytokine P40238 4352 1p34.2 human Y626-p 450267 THIANHSyLPLSYWQ carcinogenesis, induced; cell differentiation, induced; cell growth, induced; signaling pathway regulation 27222706; 33384332; 36229456 11 1 1 regulates TPO mediated signaling; regulates TPO-R signaling; increase colony-forming unit megakaryocytes +PTEN PTEN Carbohydrate Metabolism - inositol phosphate; EC 3.1.3.16; EC 3.1.3.48; EC 3.1.3.67; Motility/polarity/chemotaxis; Nuclear receptor co-regulator; PHOSPHATASE; Phosphatase, lipid; Tumor suppressor P60484 5728 10q23.31 human T232-p 456214 YSSNSGPtRREDKFM PTEN_C2 cell motility, altered 15793569 1 1 1 +CHEK1 Chk1 EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, CAMK; Protein kinase, Ser/Thr (non-receptor); Tumor suppressor O14757 1111 11q24.2 human K436-ub 6797153 NLLEMDDkILVDFRL protein degradation cell cycle regulation; carcinogenesis, inhibited; apoptosis, induced 19716789 2 1 0 +IRF3 IRF3 DNA-binding; Transcription factor Q14653 3661 19q13.33 human T253-p 55458200 PDPGMSLtDRGVMSY IRF-3 molecular association, regulation; protein conformation transcription, inhibited DNA(DISRUPTS) 27125670 1 0 0 +RPS6KA3 RSK2 EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, AGC; Protein kinase, Ser/Thr (non-receptor) P51812 6197 Xp22.12 human S19-p 7445513 KMAVESPsDSAENGQ molecular association, regulation; enzymatic activity, inhibited carcinogenesis, induced; cell motility, induced; cell growth, induced; transcription, inhibited H2AX(DISRUPTS) 33574926 1 2 0 +HOXB13 HOXB13 DNA-binding; Transcription factor Q92826 10481 17q21.32 human T8-p 34606107 MEPGNYAtLDGAKDI protein degradation; molecular association, regulation; ubiquitination; intracellular localization carcinogenesis, induced; cell growth, induced; transcription, altered SKP2(INDUCES) 37409967 1 0 1 induces nuclear translocation of NFKB +USP13 USP13 DEUBIQUITINASE; EC 3.4.19.12; Protease; Ubiquitin conjugating system; Ubiquitin-specific protease Q92995 8975 3q26.33 human S114-p 3849419 ALPKRRNsKIFLDLD protein stabilization 32772043 1 3 11 induces AurB stabilization +Ctla4 CTLA-4 Immunoglobulin superfamily; Membrane protein, integral P09793 12477 1 C2|1 30.58 cM mouse Y218-p 450898 CEKQFQPyFIPIN__ molecular association, regulation SHP-2(INDUCES) 9973379 3 0 0 +KDM4A JMJD2A DEMETHYLASE; Demethylase; EC 1.14.11.-; Oxidoreductase; Transcription, coactivator/corepressor O75164 9682 1p34.2-p34.1 human K471-sm 63115305 FEELKNVkLEEEDEE sumoylation; molecular association, regulation; methylation apoptosis, altered; chromatin organization, altered; cell growth, induced; cell motility, altered; transcription, induced; transcription, altered DNA(INDUCES) 28212444; 35914074 2 0 0 IL-10 downstream target promoting angiogenesis; SUMOylation is required for PEL cell survival, cell movement and angiogenesis; induces histone demethylation +Stk4 MST1 Autophagy; EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, STE; Protein kinase, Ser/Thr (non-receptor) Q9JI11 58231 2|2 H3 mouse T183-p 447925 DTMAKRNtVIGTPFW Pkinase enzymatic activity, induced cell adhesion, altered 12223493 25 2 5 +ADARB1 RED1 EC 3.5.4.37; Hydrolase; Nucleolus; RNA-binding P78563 104 21q22.3 human S216-p 1040254700 SASPVPAsLAQPPLP enzymatic activity, induced 29694894 1 1 0 regulation of the steady-state levels of miR-200s; metastasis suppressor activity +CERS5 LASS5 DNA-binding; EC 2.3.1.24; Membrane protein, integral; Membrane protein, multi-pass; Transferase Q8N5B7 91012 12q13.12 human S354-p 18260882 DDRSDVEsSSEEEDV enzymatic activity, induced 26887952 1 6 0 +HDAC5 HDAC5 DEACETYLASE; Deacetylase; EC 3.5.1.98; Hydrolase Q9UQL6 10014 17q21.31 human S278-p 4788482 QKVAERRsSPLLRRK molecular association, regulation; enzymatic activity, induced GPS2(INDUCES); N-CoR1(DISRUPTS); SMRT(INDUCES); HDAC3(INDUCES); TBL1X(INDUCES); TBL1XR1(INDUCES); 14-3-3 epsilon(DISRUPTS) 21081666; 22865920 2 14 0 S278/279A mutant shows a slight decrease in the deacetylation activity; reduced NCoR complex ( NCOR1, TBL1X, TBL1XR1) binding in mitotic cells allows for increased phosphorylation of this site by AurB +Slc12a5 KCC2 iso2 Membrane protein, integral; Membrane protein, multi-pass; Transporter; Transporter, SLC family Q63633-2 171373 3q42 rat T906-p 10045603 SAYTYEKtLVMEQRS SLC12 activity, inhibited 24849604; 26126716 7 4 0 +IKBKE IKKE EC 2.7.11.10; Inhibitor; KINASE; Kinase, protein; Protein kinase, Other; Protein kinase, Ser/Thr (non-receptor) Q14164 9641 1q32.1 human Y153-p 56589701 GEEGQSIyKLTDFGA Pkinase enzymatic activity, induced cell motility, induced 27287717 1 1 0 +Fech FECH Cofactor and Vitamin Metabolism - porphyrin and chlorophyll; EC 4.99.1.1; Lyase; Mitochondrial P22315 14151 18 E1|18 37.43 cM mouse S129-p 2048057 YRRIGGGsPIKMWTS Ferrochelatase enzymatic activity, induced 19691493 1 2 0 +Ep300 p300 ACETYLTRANSFERASE; Acetyltransferase; EC 2.3.1.48; Motility/polarity/chemotaxis; Nuclear receptor co-regulator; Transcription, coactivator/corepressor B2RWS6 328572 15|15 E1 mouse S2364-p 486264 MEQGHFAsPDQNSML phosphorylation transcription, induced 21498542 2 0 0 induces NFAT phosphorylation +Rxra RXRA DNA-binding; Motility/polarity/chemotaxis; Nuclear receptor P28700 20181 2 A3|2 19.38 cM mouse T167-p 1868546605 CKGFFKRtVRKDLTY zf-C4 transcription, altered 31152145 1 0 0 regulation of energy (fatty acid) metabolism, glucose homeostasis +PGR PR DNA-binding; Nuclear receptor; Transcription factor P06401 5241 11q22.1 human K388-ub 486290 QPPALKIkEEEEGAE Prog_receptor protein degradation transcription, inhibited 17347654 1 0 0 +HBP1 HBP1 DNA-binding; Transcription factor O60381 26959 7q22.3 human R378-me 1883504200 SSMARQRrASLSCGG protein degradation; ubiquitination cell growth, induced; cytoskeletal reorganization; transcription, inhibited 35941115 1 1 0 methylation alleviates HBP1-mediated suppression of metastasis and growth of tumor cells +MEF2A MEF2A DNA-binding; Motility/polarity/chemotaxis; Transcription factor Q02078 4205 15q26.3 human S255-p 456757 GKVMPTKsPPPPGGG protein degradation 12586839 1 26 0 +TRIM72 TRIM72 UBIQUITIN LIGASE; Ubiquitin conjugating system; Ubiquitin ligase Q6ZMU5 493829 16p11.2 human S255-p 27461213 LQKILAEsPPPARLD molecular association, regulation; enzymatic activity, induced signaling pathway regulation IRS1(INDUCES) 36337049 1 4 0 induces IR degradation, regulates insulin signaling +APOBEC3F APOBEC3F EC 3.5.4.-; Hydrolase; RNA processing Q8IUX4 200316 22q13.1 human S216-p 183815301 KAYGRNEsWLCFTME NAD2 enzymatic activity, inhibited DNA(DISRUPTS) 28825755 1 0 0 +CTDP1 CTDP1 EC 3.1.3.16; Motility/polarity/chemotaxis; PHOSPHATASE; Protein phosphatase, Ser/Thr (non-receptor); Transcription initiation complex Q9Y5B0 9150 18q23 human S740-p 453872 TKAQRENsPAAFPDR FCP1_C molecular association, regulation; enzymatic activity, induced transcription, induced GTF2F2(INDUCES) 12591939 1 36 0 +Elk3 ELK3 DNA-binding; Transcription factor P41971 13713 10 C2|10 48.04 cM mouse S365-p 450032 LSPVAPLsPARLQGP activity, induced; intracellular localization transcription, altered; cell growth, altered 11042694; 18356083 2 0 0 pro-B cell expansion +PARP1 PARP1 DNA repair, damage; EC 2.4.2.30; Nuclear envelope; Nuclear receptor co-regulator; Nucleolus; Transferase P09874 142 1q42.12 human K505-ac 459003 KSGAALSkKSKGQVK molecular association, regulation transcription, induced NFkB-p105(INDUCES) 16204234 1 1 0 +Slamf1 SLAM Membrane protein, integral; Receptor, misc. Q9QUM4 27218 1 H3|1 79.54 cM mouse Y335-p 447634 EPNPTTVyASVTLPE molecular association, regulation Fyn(INDUCES) 11477403 3 0 0 +Tbc1d4 AS160 GAP; GAP, Rab Q8BYJ6 210789 14|14 E2.3 mouse S577-p 455923 AKRSLTSsLENIFSR phosphorylation 33872597 5 48 81 affects phosphorylation of other sites by AKT +PPIF PPIF Cyclophilin; EC 5.2.1.8; Isomerase; Mitochondrial P30405 10105 10q22.3 human S191-p 27460203 IESFGSKsGRTSKKI Pro_isomerase molecular association, regulation apoptosis, induced OSCP1(INDUCES) 32814770 1 2 0 Regulates mitochondrial function; regulates mPTP opening and subsequent cell death +CENPT CENPT DNA replication Q96BT3 80152 16q22.1 human T85-p 3903606 SGHLEEQtPRTLLKN CENP-T_N molecular association, regulation 25660545 3 5 9 KMN network recruitment +Ppara PPAR-alpha DNA-binding; Nuclear receptor; UBIQUITIN LIGASE P37230 25747 7q34 rat S179-p 457549 RFGRMPRsEKAKLKA activity, induced; molecular association, regulation transcription, altered RXRA(INDUCES) 16042408 2 0 0 +Acly ACLY Carbohydrate Metabolism - citrate (TCA) cycle; EC 2.3.3.8; Lyase; Transferase Q91V92 104112 11|11 D mouse H750-p 9643000 SSEVQFGhAGACANQ Ligase_CoA enzymatic activity, induced 18656514 3 0 0 important for cell viability +HCRTR1 HCRTR1 GPCR, family 1; Membrane protein, integral; Membrane protein, multi-pass; Receptor, GPCR O43613 3061 1p35.2 human Y83-p 10206803 HMRTVTNyFIVNLSL 7tm_1; TM molecular association, regulation apoptosis, altered SHP-2(INDUCES) 19661287 1 0 0 +H3C1 H3 DNA-binding P68431 8350 6p22.2 human K9-ac 463820 RTKQTARkSTGGKAP Histone protein degradation; acetylation; molecular association, regulation; intracellular localization; methylation; enzymatic activity, induced cell cycle regulation; carcinogenesis, induced; carcinogenesis, inhibited; apoptosis, induced; cell growth, inhibited; transcription, induced; transcription, altered; neural plasticity; DNA repair, induced; cell growth, induced; chromatin organization, altered; cell differentiation, induced; transcription, inhibited 14-3-3 zeta(INDUCES); RARB(INDUCES); BRD7(INDUCES); WSTF(INDUCES); MLL(INDUCES); CRH(INDUCES); CHD-4(INDUCES); TIF1B(INDUCES); RARA(INDUCES); PCAF(INDUCES); CHD-1(INDUCES); TIF1G(INDUCES) DNA(INDUCES); DNA(DISRUPTS) 12482974; 15471871; 16223729; 17305432; 17498659; 17560255; 17567990; 17938209; 17968314; 17980151; 18179771; 18234970; 18418070; 18985155; 19022177; 19187761; 19196836; 19229332; 19248079; 19337993; 19407812; 19477956; 19523850; 19624289; 19787243; 19883641; 19889207; 19935671; 20043883; 20068219; 20080105; 20093418; 20094059; 20159609; 20180972; 20484083; 20720004; 20829218; 20972224; 21059703; 21196933; 21726812; 22144178; 22408259; 23287868; 23423566; 23518351; 26307012; 26310895; 27508876; 28167529; 28672915; 30867409; 31071955; 32528962; 32733069; 33087562; 34944721; 36060800; 36165173; 36413416 230 26 341 inhibits H3K9 acetylation +RAD52 RAD52 DNA repair, damage P43351 5893 12p13.33 human K323-ac 971232908 GVTQELIkTLEDNSE molecular association, regulation; intracellular localization DNA repair, induced RFA2(INDUCES); RPA3(INDUCES); RAD51(INDUCES); RPA1(INDUCES) 29590107 1 1 0 accumulation of RAD52 at DSB sites +CEACAM1 CEACAM1 Cell adhesion; Immunoglobulin superfamily; Membrane protein, integral; Motility/polarity/chemotaxis P13688 634 19q13.2 human S512-p 29576348 QPTSASPsLTATEII molecular association, regulation; methylation; phosphorylation CTNNB1(INDUCES) 34656562 1 3 0 primes phosphorylation at S508 +SPAST spastin Cytoskeletal; EC 3.6.4.3; Membrane protein, integral Q9UBP0 6683 2p22.3 human S268-p 1211782 SGHHRAPsYSGLSMV protein stabilization; molecular association, regulation; ubiquitination; intracellular localization cell cycle regulation CAND1(INDUCES) 31284535; 33106322 4 21 13 inhibits ubiquitination of spastin at K554; regulates Abscission; midbody localization during cytokinesis +SNAI1 Snail1 C2H2-type zinc finger protein; Transcription factor O95863 6615 20q13.13 human S111-p 6097705 SPPSPAPsSFSSTSV intracellular localization cell motility, altered; transcription, altered 15448698; 19004823 2 0 0 Localization mediated by S107, S111, S115 and S119. +ETS2 Ets-2 DNA-binding; Oncoprotein; Transcription factor P15036 2114 21q22.2 human T72-p 447688 NCELPLLtPCSKAVM activity, induced cell cycle regulation; cell differentiation, induced; apoptosis, inhibited; transcription, induced; transcription, altered 12628005; 15217985; 21441955; 22128184; 8552081 9 0 0 T-cell development; GSK3B transactivation +GRIA2 GluR2 Channel, calcium; Channel, ligand-gated; Membrane protein, integral; Membrane protein, multi-pass P42262 2891 4q32.1 human S880-p 448351 YNVYGIEsVKI____ activity, induced; molecular association, regulation GRIP1(DISRUPTS) 12805550; 26109571 30 1 0 criticcal for induction of cerebellar long-term depression; Synaptic scaling requires association between GluA2 and GRIP1. +Cdk1 CDK1 Cell cycle regulation; EC 2.7.11.22; EC 2.7.11.23; KINASE; Kinase, protein; Motility/polarity/chemotaxis; Protein kinase, CMGC; Protein kinase, Ser/Thr (non-receptor) P39951 54237 20p11 rat T14-p 447608 IEKIGEGtYGVVYKG Pkinase cell cycle regulation 36125973 34 117 1764 +RIGI RIGI EC 3.6.4.13; Hydrolase O95786 23586 9p21.1 human S854-p 17484202 HPKPKQFsSFEKRAK RIG-I_C-RD molecular association, regulation; enzymatic activity, inhibited RIGI(DISRUPTS) 21068236 1 1 0 dephosphorylation of T770, S855, S854 stimulates multimer formation; +SRC Src EC 2.7.10.2; KINASE; Kinase, protein; Oncoprotein; Protein kinase, TK; Protein kinase, tyrosine (non-receptor) P12931 6714 20q11.23 human S51-p 2420700 ADGHRGPsAAFAPAA enzymatic activity, inhibited; intracellular localization; phosphorylation; enzymatic activity, induced cell cycle regulation; chromatin organization, altered; cell motility, induced; cytoskeletal reorganization 29954829; 33388549 3 3 0 inhibits phosphorylation at Y419; induces autophosphorylation of Src at Y419 and phosphorylation of FAK, prevents chromosome breakage in cytokinesis +Mcm3 MCM3 DNA replication; EC 3.6.4.12 P25206 17215 1|1 A4 mouse S732-p 475062 SQEKTDDsQETQDSQ intracellular localization 17244605 2 14 1 Preferentially localized to the soluble nucleoplasmic fraction. +NKX3-1 NKX3-1 DNA-binding; Transcription factor; Tumor suppressor Q99801 4824 8p21.2 human T166-p 28750702 KNLKLTEtQVKIWFQ Homeodomain protein degradation; ubiquitination 23890999 1 0 0 +Exoc8 EXOC8 Vesicle O54924 245709 19q12 rat S28-p 480112 RLYVKQLsQQSDGDR Vps51 molecular association, regulation exocytosis, inhibited Sec5(DISRUPTS); EXOC8(DISRUPTS) 28325821 1 9 4 +H2AC11 H2A.1 DNA-binding P0C0S8 8329 6p22.1 human K13-ub 55610202 QGGKARAkAKTRSSR Histone intracellular localization DNA repair, induced 22980979; 29167269; 32424115 6 0 0 recruiting downstream DNA repair proteins to DNA breaks +Irs1 IRS1 Adaptor/scaffold; Motility/polarity/chemotaxis P35569 16367 1 C5|1 42.0 cM mouse S612-p 447562 DDGYMPMsPGVAPVP protein degradation; molecular association, regulation PIK3C2A(DISRUPTS) 10092613; 15994203 37 7 4 +HRH1 H1R GPCR, family 1; Membrane protein, integral; Membrane protein, multi-pass; Receptor, GPCR P35367 3269 3p25.3 human T142-p 453405 YLKYRTKtRASATIL 7tm_1 receptor desensitization, altered; activity, inhibited 15107581; 15328002 2 0 0 T142 phosphorylation had an inhibitory effect on T140-mediated receptor downregulation. +Kit Kit EC 2.7.10.1; KINASE; Kinase, protein; Membrane protein, integral; Oncoprotein; Protein kinase, TK; Protein kinase, tyrosine (receptor) P05532 16590 5 C3.3|5 39.55 cM mouse Y723-p 448017 SCDSSNEyMDMKPGV PK_Tyr_Ser-Thr molecular association, regulation; enzymatic activity, induced; phosphorylation cell cycle regulation; carcinogenesis, induced; cell growth, induced; signaling pathway regulation PIK3R1(INDUCES) 11090054; 12393643; 16873377; 25438940; 28923937; 7509796 18 5 52 required for required for GIST tumorigenesis; activation of oocyte PI3K signaling; Oocyte awakening; affects JNK and AKT activation/phosphorylation +UBA52-RPS27A-UBB-UBC ubiquitin Ubiquitin-like modifier P62991 mouse K63-ub 486304 LSDYNIQkESTLHLV ubiquitin protein degradation; ubiquitination; enzymatic activity, inhibited; intracellular localization; phosphorylation cell cycle regulation; cell growth, inhibited; apoptosis, induced; transcription, altered; neural plasticity; autophagy, induced; cell differentiation, induced; apoptosis, inhibited; transcription, inhibited RIGI(INDUCES) 16252010; 30886050; 30886105; 31036902; 31074883; 31127032; 31519887; 33976225; 35449295 121 39 155 nuclear localization; promotes NF-?B activation ; Lnczc3h7a promotes the antiviral response to RNA viruses; forms an electrostatic interaction with D129, loss of K133 ubiquitylation or the K133:D129 salt bridge stabilizes IL-1B; suppress production of the proinflammatory cytokines IFN-c and IL-17 by T cells, Treg gene expression and function; Lnczc3h7a noncoding RNA directly binds to the helicase domain of the activated DDX58 protein promoting K63-linked ubiquitination of DDX58; K262 is important for Treg function and stability; CYLD KO augmented short-term but impaired long-term synaptic plasticity, CYLD promotes synapse pruning in a DUB-dependent manner, CYLD directly deubiquitinates Akt and inhibits Akt phosphorylation; osteoclast differentiation, chondrocyte differentiation is impaired in Beclin1 cKO mice; impairs NFAT recruitment and transcription of NFAT-targeted genes +MYOD1 MyoD DNA-binding; RNA splicing; Transcription factor P15172 4654 11p15.1 human K99-ac 458968 RCLLWACkACKRKTT Basic molecular association, regulation; protein conformation cell differentiation, induced; transcription, induced p300(INDUCES); CBP(INDUCES) DNA(INDUCES) 10619020; 18222173 3 1 0 +MRE11 MRE11A Cell cycle regulation; DNA repair, damage; DNA-binding; Deoxyribonuclease P49959 4361 11q21 human R594-me 2344815 RGGSQRGrADTGLET intracellular localization 15970667 1 0 0 localizes in nucleus and associates with nuclear bodies and sites of DNA damage +Kcnj11 Kir6.2 Channel, potassium; Membrane protein, integral; Membrane protein, multi-pass Q61743 16514 7 B3|7 29.66 cM mouse S385-p 2103601 AKPKFSIsPDSLS__ activity, induced; protein conformation 18280666 2 3 0 +OGT OGT EC 2.4.1.255; Glycan Metabolism - O-glycan biosynthesis; O-GlcNAc TRANSFERASE; Transferase O15294 8473 Xq13.1 human S3-p 27713500 _____MAsSVGNVAD enzymatic activity, induced 23395175 1 1 0 +EEF1A2 EEF1A2 Translation; Translation elongation Q05639 1917 20q13.33 human S358-p 27930803 GQISAGYsPVIDCHT GTP_EFTU_D3 protein degradation; molecular association, regulation neural plasticity; cell growth, inhibited; cytoskeletal reorganization; translation, inhibited FLNB(INDUCES); SHRM(DISRUPTS); CAPZB iso1(INDUCES); EEF1G(DISRUPTS); RHOA(INDUCES); EEF1A1(DISRUPTS); VARS(DISRUPTS); ACTG1(DISRUPTS); CARS(DISRUPTS); eEF1B(DISRUPTS); ACTN4(INDUCES) 23608534; 34257105 2 0 0 +KDM1A LSD1 DEMETHYLASE; Demethylase; EC 1.-.-.-; Nuclear receptor co-regulator; Oxidoreductase; Transcription factor O60341 23028 1p36.12 human K117-ac 1883504201 TSRRKRAkVEYREMD protein stabilization; intracellular localization 35970393 1 1 0 cytoplasmic localization +GTF2I GTF2I DNA-binding; Transcription, coactivator/corepressor P78347 2969 7q11.23 human K240-sm 15282907 EMAAVTVkEESEDPD molecular association, regulation carcinogenesis, induced; cell growth, induced HDAC3(DISRUPTS) 25869096 1 2 1 +GRB14 GRB14 Adaptor/scaffold Q14449 2888 2q24.3 human S362-p 31834912 QGRSGCSsQSISPMR molecular association, regulation; phosphorylation INSR(DISRUPTS) 24535599; 28130417 2 2 0 +RRN3 TIF1A Nucleolus; Transcription initiation complex Q9NYV6 54700 16p13.11 human S633-p 448838 SFDTHFRsPSSSVGS cell growth, induced; transcription, induced 21098478 2 0 0 +Ptk2 FAK EC 2.7.10.2; KINASE; Kinase, protein; Protein kinase, TK; Protein kinase, tyrosine (non-receptor) P34152 14083 15 D3|15 33.94 cM mouse Y407-p 447888 IIDEEDTyTMPSTRD enzymatic activity, inhibited; phosphorylation cell cycle regulation; cell motility, altered; cell adhesion, altered; cell growth, altered 17303567 28 13 139 +DOK1 DOK1 Adaptor/scaffold; Motility/polarity/chemotaxis Q99704 1796 2p13.1 human Y146-p 455786 EMLENSLySPTWEGS molecular association, regulation DOK2(INDUCES); DOK1(INDUCES) 16177091 2 1 2 Dok1/Dok2 oligomerization required for ERK1/2 and NFAT activation +Src Src EC 2.7.10.2; KINASE; Kinase, protein; Oncoprotein; Protein kinase, TK; Protein kinase, tyrosine (non-receptor) P05480 20779 2 H1|2 78.35 cM mouse Y418-p 448234 RLIEDNEyTARQGAK PK_Tyr_Ser-Thr activity, induced; protein degradation; receptor internalization, induced; ubiquitination; enzymatic activity, induced; phosphorylation neural plasticity; endocytosis, induced; cell differentiation, induced; cell growth, induced; cell adhesion, induced; transcription, induced; signaling pathway regulation 24526685; 33550461; 34054566; 34307363; 34417202; 34675079; 35536885; 35798842; 36906292 447 103 3046 +Foxo1 FOXO1A DNA-binding; Nuclear receptor co-regulator; Oncoprotein; Transcription factor Q9R1E0 56458 3 C|3 23.19 cM mouse S475-p 478372 PPHNDIMsPVDPGVA FOXO_KIX_bdg molecular association, regulation; intracellular localization transcription, inhibited DUSP6(INDUCES) 22503562; 22848439 3 1 0 +NR5A1 STF-1 Nuclear receptor; Transcription, coactivator/corepressor Q13285 2516 9q33.3 human K72-ac 458974 CPFCRFQkCLTVGMR zf-C4 protein stabilization; intracellular localization transcription, induced 11479297 1 0 0 localization to the cytoplasm +Ccne1 CCNE1 Activator; Cell cycle regulation; Nuclear receptor co-regulator Q61457 12447 7 B3|7 25.35 cM mouse T393-p 447676 PPPSVVLtPPPSSKK protein degradation; ubiquitination; methylation; enzymatic activity, inhibited; activity, inhibited; phosphorylation cell cycle regulation; carcinogenesis, inhibited; transcription, altered; cell differentiation, altered; cell differentiation, induced; DNA repair, altered; apoptosis, inhibited; cell growth, altered 16023597; 18559482; 22405651; 23873023; 24958101 15 11 0 T74A/T393A mutation causes increased Cdk2 kinase activity and stability and regulation by Fbw7. ; using knock-in mutations impaired Fbw7-mediated degradation; required for HSCs' multilineage reconstitution ability, and prevention of chromosome instability (CIN); regulation of oxidative metabolism and ROS production during terminal maturation; Phosphorylation at T74 and T393 causes dephosphorylation of Rb and demethylation of H3K9; T393A affected cyclin E abundance and associated kinase activity. In p53 -/- cells T393A mutation increased proliferation and accelerated tumorigenesis. In p21 null cells T393A mutant caused a defect in proliferation, caused genetic instability, was more abundant, and had higher kinase activity. +MAP3K14 Nik EC 2.7.11.25; KINASE; Kinase, protein; Protein kinase, STE; Protein kinase, Ser/Thr (non-receptor) Q99558 9020 17q21.31 human S820-p 27259015 PSKASQSsRDTLSSG protein degradation 20501937 2 1 0 IKKA-dependent destabilization of Nik +Ppp2ca PPP2CA EC 3.1.3.16; Motility/polarity/chemotaxis; PHOSPHATASE; Protein phosphatase, Ser/Thr (non-receptor) P63331 24672 10q22 rat L309-me 3627520 RRTPDYFl_______ molecular association, regulation PPP2CB(DISRUPTS) 17537547 10 0 0 Demethylated, phosphorylated PPP2CA decreased binding to PPP2CB. +Cdh5 CDH5 Cell adhesion; Membrane protein, integral; Motility/polarity/chemotaxis P55284 12562 8 D3|8 53.04 cM mouse Y731-p 456049 PYDTLHIyGYEGAES CADH_Y-type_LIR receptor internalization, induced; molecular association, regulation apoptosis, induced; cell motility, altered; endocytosis, inhibited CTNNB1(DISRUPTS) 18096689; 24487320; 34914018; 37237266 16 0 1 +Kmt2a MLL Cell cycle regulation; EC 2.1.1.43; METHYLTRANSFERASE; Methyltransferase; Methyltransferase, protein lysine; Oncoprotein; Transcription factor P55200 214162 9 A5.2|9 24.84 cM mouse K1127-ac 11319706 EPLAPPIkPIKPVTR transcription, induced 25751424 1 3 0 +Nr4a2 NR4A2 DNA-binding; Nuclear receptor Q06219 18227 2 C1.1|2 31.66 cM mouse T132-p 487426 SSPPTPStPSFQVQH intracellular localization 25752609 2 0 0 cytoplasmic translocation, required for H2O2-induced necrosis +Pth1r PTHR GPCR, family 2; Membrane protein, integral; Membrane protein, multi-pass; Receptor, GPCR P25961 56813 8q32 rat S491-p 452061 KRKARSGsSSYSYGP receptor internalization, altered; activity, inhibited 11773434; 18577695 5 4 0 +PLCG2 PLCG2 Carbohydrate Metabolism - inositol phosphate; EC 3.1.4.11; Motility/polarity/chemotaxis; Phospholipase P16885 5336 16q23.3 human Y753-p 447940 ERDINSLyDVSRMYV molecular association, regulation; enzymatic activity, induced LYN(INDUCES) 12780340; 15184383; 30344948 10 11 270 intramolecular tyrosine-phosphorylation and Rac mediated activation +Gja1 GJA1 Channel, misc.; Membrane protein, integral; Membrane protein, multi-pass; Motility/polarity/chemotaxis P08050 24392 20q11 rat S282-p 448854 TAPLSPMsPPGYKLV molecular association, regulation; intracellular localization; activity, inhibited apoptosis, induced; apoptosis, inhibited GJA1(INDUCES) 23922949; 26841867; 30770876; 34931018; 9535909 42 7 1 +TTK TTK Cancer Testis Antigen (CTA); EC 2.7.12.1; KINASE; Kinase, protein; Protein kinase, Other; Protein kinase, dual-specificity (non-receptor) P33981 7272 6q14.1 human S742-p 4145509 QQIINQIsKLHAIID Pkinase enzymatic activity, induced 18680479 1 0 0 in vitro +NFKB2 NFkB-p100 DNA-binding; Oncoprotein; Transcription factor Q00653 4791 10q24.32 human K90-sm 3055611 CNYEGPAkIEVDLVT RHD_DNA_bind protein processing; phosphorylation signaling pathway regulation 18617892 1 0 0 activation of alternative NF-kB pathway +Klc1 KLC1 Microtubule-binding; Motor P37285 171041 6q32 rat S460-p 477826 YKACKVDsPTVTTTL molecular association, regulation CLSTN1(DISRUPTS) 21385839 3 41 3 +CERT1 COL4A3BP EC 2.7.11.9; KINASE; Kinase, protein; Lipid-binding; Protein kinase, Ser/Thr (non-receptor); Protein kinase, atypical Q9Y5P4 10087 5q13.3 human S132-p 483985 SSLRRHGsMVSLVSG molecular association, regulation; intracellular localization; enzymatic activity, inhibited; protein conformation; activity, inhibited exocytosis, altered COL4A3BP(INDUCES) 17442665; 17591919; 19005213; 21285358; 28652409; 29541394; 29848549 7 12 13 reduced PtdIns(4)P binding affinity as well as low ceramide transfer activity, E494R/N495K/P535R/E537K mutations, recovery of both PtdIns(4)P binding and ceramide transfer activity.; intracellular GPBP multimerization; regulates PI(4)P uptake; inhibited exportation; CERT SRM interacts with the CERT PH domain +ROCK1 ROCK1 EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, AGC; Protein kinase, Ser/Thr (non-receptor) Q13464 6093 18q11.1 human T1334-p 1210778 ASPRTLStRSTANQS intracellular localization cytoskeletal reorganization 21685893 1 2 4 inhibits apical constriction +ALDH1A1 ALDH1A1 Apoptosis; Cofactor and Vitamin Metabolism - retinol; EC 1.2.1.36; GAP; GAP, Ras; Oxidoreductase P00352 216 9q21.13 human T493-p 63070900 YTEVKTVtVKISQKN protein stabilization; ubiquitination; intracellular localization; protein conformation; enzymatic activity, induced carcinogenesis, induced; cell motility, induced; cell growth, induced; transcription, induced ALDH1A1(DISRUPTS) 28193222 1 0 0 inhibits ubiquitination, induces drug resistance, T267 site ALDHA1A1 increases enzymatic activity, oligomers dissociate to the monomeric form +Camk1 CAMK1A EC 2.7.11.17; KINASE; Kinase, protein; Protein kinase, CAMK; Protein kinase, Ser/Thr (non-receptor) Q63450 171503 4q42 rat T177-p 448527 DPGSVLStACGTPGY Pkinase molecular association, regulation NUMBL(INDUCES); SYN1(INDUCES); CREB iso1(INDUCES) 16105844 10 6 7 +SLN sarcolipin Endoplasmic reticulum; Membrane protein, integral P42532 100009246 rabbit T5-p 459214 ___MERStRELCLNF Sarcolipin molecular association, regulation SERCA2(INDUCES) 16461894 6 0 0 +NDUFB6 NDUFB6 EC 1.6.5.3; EC 1.6.99.3; Energy Metabolism - oxidative phosphorylation; Membrane protein, integral; Mitochondrial; Oxidoreductase O95139 4712 9p21.1 human T5-p 33402202 ___MTGYtPDEKLRL NDUF_B6 activity, induced cell cycle regulation 24746669 1 1 0 increases mitochondrial respiration for G/2M transition +SP7 osterix C2H2-type zinc finger protein; DNA-binding; Transcription factor Q8TDD2 121340 12q13.13 human K307-ac 56714900 GCGKVYGkASHLKAH zf-C2H2 protein stabilization; molecular association, regulation cell differentiation, induced; transcription, induced DNA(INDUCES) 27250035 1 0 0 +NR1H4 NR1H4 DNA-binding; Nuclear receptor Q96RI1 9971 12q23.1 human K227-ac 12159006 KRLRKNVkQHADQTV protein stabilization; molecular association, regulation transcription, inhibited RXRA(DISRUPTS) DNA(DISRUPTS) 19883617 1 1 0 +CAPZA1 CAPZA1 Actin-binding; Motility/polarity/chemotaxis P52907 829 1p13.2 human S126-p 1870026100 SWRESCDsALRAYVK F-actin_cap_A cell motility, induced; cell adhesion, induced; cytoskeletal reorganization 32771000 1 1 0 +Anxa2 ANXA2 Calcium-binding; Lipid-binding; Motility/polarity/chemotaxis P07356 12306 9 C|9 38.58 cM mouse K10-sm 40493900 TVHEILCkLSLEGDH cytoskeletal reorganization 25775977 1 0 0 +YAP1 YAP1 Oncoprotein; Transcription, coactivator/corepressor P46937 10413 11q22.1 human S109-gl 1873529902 KSHSRQAsTDAGTAG activity, induced; protein stabilization; molecular association, regulation; intracellular localization; phosphorylation carcinogenesis, induced; cell motility, induced; transcription, induced LATS2(DISRUPTS); LATS1(DISRUPTS) 34155345 1 0 0 inhibits YAP1-S127 phosphorylation +FPR2 FPR2 GPCR, family 1; Membrane protein, integral; Membrane protein, multi-pass; Motility/polarity/chemotaxis; Receptor, GPCR P25090 2358 19q13.41 human S237-p 3176602 KKGMIKSsRPLRVLT 7tm_1 receptor desensitization, altered 11063592 1 0 0 downregulates PLA2 and PLD activation +EGFR EGFR EC 2.7.10.1; KINASE; Kinase, protein; Membrane protein, integral; Oncoprotein; Protein kinase, TK; Protein kinase, tyrosine (receptor) P00533 1956 7p11.2 human S768-p 452119 DEAYVMAsVDNPHVC PK_Tyr_Ser-Thr enzymatic activity, inhibited 29695735 6 0 0 decrease ligand-independent phosphorylation of both the activation loop (Y845) and the C-terminal tail (Y1197) compared to wild-type and oncogenic (S768I) EGFR +Trpc6 TRPC6 Channel, cation; Membrane protein, integral; Membrane protein, multi-pass Q61143 22068 9 A1|9 2.46 cM mouse T487-p 27839400 RQLFRMKtSCFSWME Ion_trans; TM activity, induced 23529130 1 0 0 Regulates channel activity induced by AVP receptor stimulation +Myod1 MyoD DNA-binding; RNA splicing; Transcription factor P10085 17927 7 B3|7 30.03 cM mouse S200-p 40684505 SGDSDASsPRSNCSD Myf5 protein degradation; molecular association, regulation; intracellular localization cell differentiation, inhibited; cell cycle regulation; transcription, altered HDAC1(INDUCES); PCAF(DISRUPTS) DNA(DISRUPTS) 10082583; 14749395; 17014844; 27823936; 9710583 8 1 0 protein stability alone contributes to the enhanced activity of S200A mutant +SPHK1 SPHK1 ACETYLTRANSFERASE; Acetyltransferase; EC 2.3.1.-; EC 2.7.1.91; Kinase, lipid; Lipid Metabolism - sphingolipid Q9NYA1 8877 17q25.1 human S225-p 460682 VGSKTPAsPVVVQQG molecular association, regulation; intracellular localization; phosphorylation; enzymatic activity, induced carcinogenesis, altered; apoptosis, inhibited; cell growth, altered ITGB3(INDUCES); PECAM-1(INDUCES) Other(INDUCES) 14532121; 15623571; 16243846; 18852266; 19815712; 21075214 14 8 0 +HMGN1 HMGN1 DNA-binding; Nuclear receptor co-regulator P05114 3150 21q22.2 human K27-ac 458845 RSARLSAkPPAKVEA HMG14_17 molecular association, regulation DNA(DISRUPTS) 10753971 1 2 0 +MYH9 MYH9 Actin-binding; Motility/polarity/chemotaxis; Motor P35579 4627 22q12.3 human S1808-p 2482304 VKSKYKAsITALEAK Myosin_tail_1 intracellular localization cytoskeletal reorganization 18394644 1 4 0 +KMT2E MLL5 Cell cycle regulation; EC 2.1.1.43; METHYLTRANSFERASE; Methyltransferase; Methyltransferase, protein lysine; Transcription, coactivator/corepressor Q8IZD2 55904 7q22.3 human T912-p 14645300 PMDPSFAtPPRIKSD intracellular localization cell cycle regulation 20439461 1 0 2 +ARHGEF2 ARHGEF2 GEF; GEF, Rac/Rho; Motility/polarity/chemotaxis Q92974 9181 1q22 human S886-p 451365 PVDPRRRsLPAGDAL molecular association, regulation; enzymatic activity, inhibited; activity, inhibited; phosphorylation cell differentiation, inhibited; cell cycle regulation; cytoskeletal reorganization; signaling pathway regulation 14-3-3 beta(INDUCES); 14-3-3 zeta(INDUCES) 14970201; 15827085; 17488622; 33762326 12 47 145 regulates GEF-H1/RhoA/ROCK pathway +Ets1 Ets-1 DNA-binding; Motility/polarity/chemotaxis; Oncoprotein; Transcription factor P27577 23871 9 A4|9 17.97 cM mouse S285-p 449318 QRVPSYDsFDYEDYP Ets1_N_flank molecular association, regulation; acetylation; intracellular localization transcription, inhibited DNA(DISRUPTS) 30865889 6 10 56 induce acetylation of FOXO1 and suppress gluconeogenesis +H1-4 H1E DNA-binding P10412 3008 6p22.2 human T146-p 458356 KKATGAAtPKKSAKK cell cycle regulation; cell growth, altered 24601643; 24873882 5 11 8 +MAFA MAFA DNA-binding; Oncoprotein; Transcription factor; Tumor suppressor Q8NHW3 389692 8q24.3 human K32-sm 6124705 DLMKFEVkKEPPEAE transcription, inhibited 19029092 2 0 0 +CHN2 ARHGAP3 GAP; GAP, Rac/Rho P52757 1124 7p14.3 human Y153-p 473503 KMTTNPIyEHIGYAT intracellular localization; activity, inhibited cytoskeletal reorganization 19201754 1 2 146 +Hdac4 HDAC4 DEACETYLASE; Deacetylase; EC 3.5.1.98; Hydrolase; Nuclear receptor co-regulator; SUMO LIGASE Q99P99 363287 9q36 rat S630-p 448490 RPLSRAQsSPASATF molecular association, regulation transcription, induced AML3(DISRUPTS) 24904057 11 40 71 +KCNK18 KCNK18 Channel, ligand-gated; Channel, potassium; Membrane protein, integral; Membrane protein, multi-pass Q7Z418 338567 10q25.3 human S267-p 13383301 RLSYSIIsNLDEVGQ intracellular localization; activity, inhibited transcription, inhibited 30327410 3 0 0 +GP1BA GPIbA Cell adhesion; Cell surface; Membrane protein, integral P07359 2811 17p13.2 human S601-p 11333102 WLLFLRGsLPTFRSS molecular association, regulation FLNA(DISRUPTS); 14-3-3 zeta(INDUCES); VWF(INDUCES) 19875727 1 1 0 +CXCR4 CXCR4 GPCR, family 1; Membrane protein, integral; Membrane protein, multi-pass; Receptor, GPCR P61073 7852 2q22.1 human K331-ub 12324739 SSLKILSkGKRGGHS protein degradation 24489825 1 0 1 +DTD1 DTD1 DNA replication; EC 3.1.-.-; Hydrolase Q8TEA8 92675 20p11.23 human S194-p 3072143 TPRKEDRsASSGAEG molecular association, regulation cell cycle regulation; cell growth, induced MCM7(INDUCES); MCM3(DISRUPTS) 25258324 1 13 0 decreases DTD1 incorporation into HMW, supports DNA replication initiation +MDM2 MDM2 EC 6.3.2.-; EC 6.3.2.19; Inhibitor; Ligase; NEDDYLATION LIGASE; Neddylation Ligase; Nucleolus; Oncoprotein; UBIQUITIN LIGASE; Ubiquitin conjugating system; Ubiquitin ligase Q00987 4193 12q15 human S407-p 450263 SSSIIYSsQEDVKEF molecular association, regulation; enzymatic activity, inhibited; protein conformation p53(DISRUPTS) 21986495 2 3 0 oligomerization inhibited +STIM1 STIM1 Calcium-binding; Endoplasmic reticulum; Membrane protein, integral Q13586 6786 11p15.4 human S628-p 9257903 SPDPDTPsPVGDSRA molecular association, regulation; intracellular localization cytoskeletal reorganization EB1(DISRUPTS) 22748319 1 10 5 phosphorylation dissociates STIM1 from EB1 during mitosis, and excludes ER from the mitotic spindle +MAP3K9 MLK1 EC 2.7.11.25; KINASE; Kinase, protein; Protein kinase, Ser/Thr (non-receptor); Protein kinase, TKL P80192 4293 14q24.2 human T312-p 455217 TKMSAAGtYAWMAPE Pkinase activity, induced 15610029 1 0 0 +Irf7 IRF7 DNA-binding; Transcription factor P70434 54123 7|7 F5 mouse S437-p 486437 SSLGLCLsSTNSLYE transcription, induced DNA(INDUCES) 15743772; 33976210 3 0 0 +GATA3 GATA3 Transcription factor P23771 2625 10p14 human T156-p 33638003 HLFTFPPtPPKDVSP protein degradation; ubiquitination FBXW7(INDUCES) 24820417 1 0 0 +FEN1 FEN1 DNA repair, damage; DNA-binding; Deoxyribonuclease; EC 3.1.-.-; Nuclear receptor co-regulator; Nucleolus; Ribonuclease P39748 2237 11q12.2 human K380-ac 460620 AGKFKRGk_______ molecular association, regulation; enzymatic activity, inhibited DNA(DISRUPTS) 11430825 1 1 0 +Sik3 QSK EC 2.7.11.1; KINASE; Kinase, protein; Motility/polarity/chemotaxis; Protein kinase, CAMK; Protein kinase, Ser/Thr (non-receptor) Q6P4S6 70661 9|9 A5.2 mouse T221-p 456036 TPGQLLKtWCGSPPY Pkinase enzymatic activity, inhibited; phosphorylation; enzymatic activity, induced transcription, altered; signaling pathway regulation 35997995; 36477534 8 17 14 induces HDAC4 phosphorylation and thus induces QSK?HDAC4 signalling +Bcl2l11 BIM Apoptosis O54918 12125 2|2 F1 mouse S114-p 449072 DKSTQTPsPPCQAFN protein stabilization; molecular association, regulation apoptosis, induced Bcl-2(INDUCES); Bcl-xL(INDUCES) 23832115 5 6 0 +G6PD G6PD Carbohydrate Metabolism - pentose phosphate pathway; Cell development/differentiation; EC 1.1.1.49; Other Amino Acids Metabolism - glutathione; Oxidoreductase P11413 2539 Xq28 human K386-ac 11320999 DIFHQQCkRNELVIR G6PD_C enzymatic activity, altered 37798264 1 2 0 +Myod1 MyoD DNA-binding; RNA splicing; Transcription factor P10085 17927 7 B3|7 30.03 cM mouse T115-p 452044 ADRRKAAtMRERRRL HLH activity, inhibited 17761773 2 0 0 regulates slow to fast MyHC fibre type transformation +Myl12b MRLC2 Contractile P18666 50685 9q38 rat T19-p 448596 KKRPQRAtSNVFAMF protein conformation exocytosis, altered 18283106 36 50 282 +TBCB TBCB Chaperone; Cytoskeletal; Motility/polarity/chemotaxis Q99426 1155 19q13.12 human S128-p 455785 VRSFLKRsKLGRYNE cytoskeletal reorganization 15831477; 18048340 2 0 0 +FIS1 FIS1 Membrane protein, integral; Mitochondrial Q9Y3D6 51024 7q22.1 human Y38-p 1875830300 SKSTQFEyAWCLVRS Fis1_TPR_N carcinogenesis, induced; cell motility, induced; cytoskeletal reorganization DRP1(INDUCES) 34848680 1 1 0 recruits Drp1 to mitochondria +SP1 SP1 C2H2-type zinc finger protein; DNA-binding; Transcription factor P08047 6667 12q13.13 human S641-gl 5262504 GKVYGKTsHLRAHLR zf-C2H2 transcription, induced 18513490 2 1 0 +ABL1 Abl EC 2.7.10.2; KINASE; Kinase, protein; Oncoprotein; Protein kinase, TK; Protein kinase, tyrosine (non-receptor) P00519 25 9q34.12 human T735-p 450291 DTEWRSVtLPRDLQS molecular association, regulation; intracellular localization; enzymatic activity, induced apoptosis, induced; apoptosis, inhibited 14-3-3 beta(INDUCES); 14-3-3 beta(DISRUPTS) 15696159; 16888623; 18794806; 19643477 5 2 1 +PPP1CA PPP1CA EC 3.1.3.16; Nucleolus; PHOSPHATASE; Protein phosphatase, Ser/Thr (non-receptor) P62136 5499 11q13.2 human T320-p 448686 NPGGRPItPPRNSAK enzymatic activity, inhibited; activity, inhibited; phosphorylation cell cycle regulation; cell differentiation, altered; cytoskeletal reorganization 12202491; 17202132; 21996745; 35081344 24 43 98 inhibits MAP4 phosphorylation +Bcl11b Bcl-11B C2H2-type zinc finger protein; Nuclear receptor co-regulator; Transcription regulation Q99PV8 58208 12 F1|12 59.1 cM mouse S277-p 14159419 GPETVAQsPLMNFLG molecular association, regulation SENP1(INDUCES) 22700985 0 6 1 +OGFOD1 OGFOD1 EC 1.14.11.-; Oxidoreductase Q8N543 55239 16q13 human S256-p 1874115106 FEPPIPRsPHIPQDH carcinogenesis, induced; cell motility, induced; cell growth, induced; transcription, induced 34298635 1 0 0 +ADORA2A ADORA2A GPCR, family 1; Membrane protein, integral; Membrane protein, multi-pass; Receptor, GPCR P29274 135 22q11.23 human S374-p 13417800 SGGSAQEsQGNTGLP molecular association, regulation DRD2(INDUCES) 20197060 1 0 0 +IRAK1 IRAK1 EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, Ser/Thr (non-receptor); Protein kinase, TKL P51617 3654 Xq28 human K134-ub 2134713 AEAWSPRkLPSSAST protein degradation transcription, induced; signaling pathway regulation 18326498; 29038250 3 0 0 activation of TLR9 ligand-induced inflammatory signaling +Chrnb1 nAChRB1 Channel, cation; Channel, ligand-gated; Membrane protein, integral; Membrane protein, multi-pass P09690 11443 11 B3|11 42.87 cM mouse Y390-p 2562301 WGRGTDEyFIRKPPS Neur_chan_memb molecular association, regulation RAPsyn(INDUCES) 18987183 3 1 4 increases nAchRB1 clustering +Vim Vimentin Cytoskeletal; Motility/polarity/chemotaxis P20152 22352 2 A1|2 10.04 cM mouse S72-p 449026 SSAVRLRsSVPGVRL Filament_head cytoskeletal reorganization 12458200 21 34 40 +CASP8 CASP8 iso4 Apoptosis; EC 3.4.22.61; Protease Q14790-4 841 2q33.1 human Y465-p 1032277 TILTEVNyEVSNKDD Peptidase_C14 enzymatic activity, inhibited; enzymatic activity, induced apoptosis, inhibited 27101103 2 2 0 Src activated by CASP8 Y397 and Y465 phosphorylation; prevents its cleavage +PECAM1 PECAM-1 Cell adhesion; Cell development/differentiation; Membrane protein, integral; Motility/polarity/chemotaxis P16284 5175 17q23.3 human Y690-p 448759 PLNSDVQyTEVQVSS activity, induced; molecular association, regulation cytoskeletal reorganization; cell adhesion, altered SHP-2(INDUCES) 10704309; 11927609; 12535670; 15201144; 9312087 9 0 44 +MYC Myc DNA-binding; Nucleolus; Oncoprotein; Transcription factor P01106 4609 8q24.21 human K163-sm 40724405 AAKLVSEkLASYQAA Myc_N protein degradation; ubiquitination transcription, inhibited 25895136 1 2 0 +Espl1 separase EC 3.4.22.49; Protease P60330 105988 15|15 F3 mouse S1121-p 447673 IQSSVNSsPVLKTKP molecular association, regulation; enzymatic activity, inhibited; activity, inhibited cell cycle regulation; chromatin organization, altered; cell growth, inhibited; cell growth, induced; apoptosis, inhibited; cell growth, altered CCNB1(INDUCES) 16030258; 18232736; 19124608; 22814604; 36450246 11 10 0 +Prkaa2 AMPKA2 Autophagy; EC 2.7.11.1; EC 2.7.11.27; EC 2.7.11.31; KINASE; Kinase, protein; Protein kinase, CAMK; Protein kinase, Ser/Thr (non-receptor) Q8BRK8 108079 4|4 C6 mouse S491-p 450432 STPQRSCsAAGLHRA AdenylateSensor enzymatic activity, inhibited 26797128 13 12 2 +Dvl2 DVL2 Adaptor/scaffold; Motility/polarity/chemotaxis Q60838 13543 11 B3|11 42.96 cM mouse S143-p 7320089 FHPNVSSsHENLEPE Dishevelled molecular association, regulation carcinogenesis, induced; cell differentiation, induced; transcription, induced; signaling pathway regulation DVL2(INDUCES) 33637566 4 3 1 Wnt/?-catenin pathway +VAV1 VAV1 GEF; GEF, Rac/Rho; Motility/polarity/chemotaxis; Oncoprotein P15498 7409 19p13.3 human Y844-p 454086 VEEDYSEyC______ carcinogenesis, altered; cell growth, altered 20457609 1 17 467 +SKI SKI Cell cycle regulation; Oncoprotein; Transcription, coactivator/corepressor; Ubiquitin conjugating system P12755 6497 1p36.33-p36.32 human T458-p 11279400 QPRKRKLtVDTPGAP protein degradation transcription, altered 19875456 1 0 2 reduces the activation of TGF-beta signaling +FOXC2 FOXC2 Apoptosis; Cell development/differentiation; DNA-binding; Transcription factor Q99958 2303 16q24.1 human S251-p 7322587 AASTPAGsPDGSLPE molecular association, regulation transcription, altered DNA(INDUCES) 23878394 1 1 0 implicated in vascular remodeling in vivo +BACE1 BACE EC 3.4.23.46; Membrane protein, integral; Protease P56817 23621 11q23.3 human K285-ac 478259 CKEYNYDkSIVDSGT Asp protein stabilization; intracellular localization 17425515 1 1 0 regulates translocation through secretory pathway +NRF1 NRF1 DNA-binding; Transcription factor Q16656 4899 7q32.2 human T259-p 23255803 QKQRVSWtQALRTIV Nrf1_DNA-bind molecular association, regulation; intracellular localization signaling pathway regulation NRF1(INDUCES) 30642892 1 0 1 +BRCA1 BRCA1 EC 6.3.2.-; Nuclear receptor co-regulator; Transcription, coactivator/corepressor; Tumor suppressor; UBIQUITIN LIGASE; Ubiquitin conjugating system; Ubiquitin ligase P38398 672 17q21.31 human S1280-p 767901 QVILAKAsQEHHLSE intracellular localization 17531442 2 6 0 S1143 and S1280 phosphorylation contributes to BRCA1 recruitment to MMTS-induced foci. +Rbm7 RBM7 RNA-binding Q9CQT2 67010 9|9 A5.3 mouse S136-p 453069 QMVQRSFsSPEDYQR molecular association, regulation RNA(DISRUPTS) 25525152 2 50 103 +FBXL20 FBXL20 UBIQUITIN LIGASE; Ubiquitin ligase Q96IG2 84961 17q12 human T417-p 467016 HAYFAPVtPPPSVGG protein degradation; molecular association, regulation carcinogenesis, inhibited; cell growth, inhibited; apoptosis, induced FBXO31(INDUCES) 34587475 1 54 61 +Gfap GFAP Cytoskeletal P03995 14580 11 E1|11 66.48 cM mouse S8-p 449618 MERRRITsARRSYAS Filament_head molecular association, regulation autophagy, inhibited 14-3-3 gamma(INDUCES) 17032734; 33048163 9 0 0 +H4c2 H4 DNA-binding P62804 295277 rat K8-ac 458959 SGRGKGGkGLGKGGA transcription, induced 19909801 85 21 529 +ATXN3 ataxin-3 DEUBIQUITINASE; DNA repair, damage; EC 3.4.19.12; Protease; Transcription regulation; Ubiquitin-specific protease P54252 4287 14q32.12 human S347-p 9441000 LQAAVTMsLETVRND UIM activity, induced; protein stabilization; intracellular localization transcription, altered 19542537 1 0 0 +FBXO3 FBXO3 UBIQUITIN LIGASE; Ubiquitin conjugating system; Ubiquitin ligase Q9UK99 26273 11p13 human T82-p 1871994100 WKSLFIDtYSDVGRY protein degradation; protein stabilization carcinogenesis, induced; cell motility, induced 33626035 2 0 0 induces protein stabilization of FBXO3 and protein degradation of ?Np63a +BACE1 BACE EC 3.4.23.46; Membrane protein, integral; Protease P56817 23621 11q23.3 human S498-p 450178 DDFADDIsLLK____ sumoylation; protein degradation; intracellular localization; enzymatic activity, induced PACS-1(INDUCES); Rab7(DISRUPTS) 11278841; 15615712; 24305806; 28946017; 37286480 7 4 0 inhibits sumoylation; decreased TGN localization +WASF2 WAVE2 Actin-binding; Motility/polarity/chemotaxis Q9Y6W5 10163 1p36.11 human S308-p 12626400 PPAPPLGsPPGPKPG molecular association, regulation cell motility, altered; cytoskeletal reorganization 21419341 1 11 0 regulates WRC (WAVE2 regulatory complex) interaction with Arp2/3 and lamellipodial protrusion +FLNC FLNC Cytoskeletal; Motility/polarity/chemotaxis Q14315 2318 7q32.1 human S2624-p 15403523 SSSSRGSsYSSIPKF protein stabilization 28028127 1 15 0 +CBY1 CBY1 Transcription regulation Q9Y3M2 25776 22q13.1 human S20-p 2850009 TPPRKSAsLSNLHSL Chibby molecular association, regulation; intracellular localization transcription, altered 14-3-3 zeta(INDUCES) 18573912; 25909186 2 24 0 interaction of PGEA1 with 14-3-3 zeta contributes to the formation of trimolecular complex with CTNNB1 +SFPQ PSF Nuclear receptor co-regulator; RNA splicing; RNA-binding P23246 6421 1p34.3 human T687-p 449362 PRGMGPGtPAGYGRG molecular association, regulation BCLAF1(INDUCES); Trap150(INDUCES) 20932480 1 34 58 TRAP150-PSF interaction regulates CD45 splicing by blocking PSF from interacting with CD45 pre-mRNA in resting T cells +Ctnnb1 CTNNB1 Actin-binding; Cell adhesion; Motility/polarity/chemotaxis; Nuclear receptor co-regulator; Oncoprotein; Transcription factor Q9WU82 84353 8q32 rat S675-p 457120 QDYKKRLsVELTSSL protein stabilization; intracellular localization cell cycle regulation; autophagy, induced; cell motility, induced; cell growth, induced; transcription, induced; signaling pathway regulation 33518533; 35012644 40 55 17 induces PKA/?-catenin/CTH pathway +Ywhab 14-3-3 beta Adaptor/scaffold P35213 56011 3q42 rat T143-p 3136106 SGDNKQTtVSNSQQA 14-3-3 molecular association, regulation RAF1(DISRUPTS); PKCZ(DISRUPTS) 10620507 1 0 0 +Zfp36 TTP DNA-binding; RNA-binding P22893 22695 7 A3-B1|7 16.72 cM mouse S316-p 451153 LPIFNRIsVSE____ molecular association, regulation; intracellular localization RNA stability, induced; transcription, induced 14-3-3 beta(INDUCES); NOT1(DISRUPTS) 34090459 2 11 0 +H4c2 H4 DNA-binding P62804 295277 rat K16-ac 458960 GLGKGGAkRHRKVLR transcription, induced 19909801 106 26 531 +EIF6 EIF6 Nucleolus; Translation; Translation initiation P56537 3692 20q11.22 human S235-p 450271 QPSTIATsMRDSLID activity, induced; molecular association, regulation; intracellular localization carcinogenesis, induced; translation, altered; translation, induced Other(DISRUPTS) 14654845; 21665150; 32703900 3 5 2 +Nrip1 RIP140 Nuclear receptor co-regulator; Transcription, coactivator/corepressor Q8CBD1 268903 16|16 C3.1 mouse K158-ac 459035 QQIRQSLkEQGYALS NRIP1_repr_1 activity, induced; intracellular localization transcription, inhibited 15879431; 18655826 1 2 0 enhanced fat accumulation in differentiated adipocytes +Ppp2r5b PPP2R5B Motility/polarity/chemotaxis; Protein phosphatase, regulatory subunit Q6PD28 225849 19|19 A mouse S48-p 23134678 PRRSHSSsQFRYQSN molecular association, regulation; phosphorylation PPP2CA(INDUCES); PPP2R5B(INDUCES) 21329884 1 2 3 PPP2R2R5B phosphorylation by CLK2 is required for the PPP2CA-AKT complex; induces AKT dephosphorylation +MYBBP1A MYBBP1A DNA replication; DNA-binding; Nucleolus; RNA-binding Q9BQG0 10514 17p13.2 human S1303-p 3210687 ARKKARLsLVIRSPS cell cycle regulation 20177074 2 21 2 +Cnr1 CNR1 GPCR, family 1; Membrane protein, integral; Membrane protein, multi-pass; Receptor, GPCR P47746 12801 4 A5|4 16.28 cM mouse S469-p 22342303 MSVSTDTsAEAL___ receptor desensitization, induced 22014214 1 0 0 +Nedd4l NEDD4L EC 6.3.2.-; EC 6.3.2.19; Ligase; UBIQUITIN LIGASE; Ubiquitin conjugating system; Ubiquitin ligase Q8CFI0 83814 18|18 E1 mouse S371-p 453438 SSRLRSCsVTDTVAE protein stabilization; molecular association, regulation; intracellular localization cell differentiation, induced; translation, induced 14-3-3 epsilon(INDUCES) 21900244; 24705297; 33064840 14 17 59 +Map3k5 ASK1 EC 2.7.11.25; KINASE; Kinase, protein; Protein kinase, STE; Protein kinase, Ser/Thr (non-receptor) O35099 26408 10|10 A3 mouse S1036-p 1984030 DENFEDHsAPPSPEE enzymatic activity, inhibited; phosphorylation 35438255 0 21 0 inhibits p38 phosphorylation +MYH9 MYH9 Actin-binding; Motility/polarity/chemotaxis; Motor P35579 4627 22q12.3 human S1916-p 451181 AMNREVSsLKNKLRR Myosin_tail_1 molecular association, regulation; intracellular localization carcinogenesis, induced; exocytosis, induced; cell motility, induced; cell adhesion, induced; cytoskeletal reorganization; cell adhesion, altered HBXIP(INDUCES) 25544611; 28053086; 29208598; 36970214 11 3 8 +H3C1 H3 DNA-binding P68431 8350 6p22.2 human K9-m2 459006 RTKQTARkSTGGKAP Histone molecular association, regulation; methylation; enzymatic activity, inhibited; intracellular localization cell cycle regulation; cell differentiation, inhibited; carcinogenesis, induced; carcinogenesis, inhibited; cell growth, inhibited; cell motility, induced; cell motility, inhibited; transcription, induced; transcription, altered; cell differentiation, induced; cell growth, induced; chromatin organization, altered; transcription, inhibited CAF-1A(INDUCES); UHRF2(INDUCES); CHD-4(INDUCES); KRTAP1-1(INDUCES); PHF8(INDUCES); TIF1B(INDUCES); HP1 alpha(INDUCES); ERCC6(INDUCES); requiem(INDUCES); ANP32B(INDUCES); ANP32A(INDUCES); CBX1(INDUCES); HP1BP3(INDUCES) DNA(INDUCES) 16079795; 16732292; 16732293; 16858404; 16982742; 17980151; 18628788; 18701507; 18835819; 19022177; 19187761; 19337993; 19460472; 19477956; 19546172; 19624289; 19706462; 19787243; 19889207; 20080105; 20152814; 20346720; 20421419; 20439491; 20546607; 20547755; 20548336; 21059703; 21532585; 23423566; 23518351; 25535969; 25548279; 25749385; 25789554; 27694900; 28672915; 30377265; 35293595; 36872368; 37749225 119 21 0 H3K9m3 leads to heterochromatin and proliferation; transcriptional repression; AMPKA2 induced PHF2-S655 phosphorylation suppresses cell migration, invasion, and metastasis. +ELMO1 ELMO1 Cytoskeletal; Motility/polarity/chemotaxis Q92556 9844 7p14.2-p14.1 human Y216-p 455872 VLNSHDLyQKVAQEI ELMO_ARM molecular association, regulation; intracellular localization NCK1(INDUCES); RHOG(INDUCES) 24928514 3 2 0 Nck1 enhances ELMO1 and RhoG interaction and promotes Rac1 activity; localization of ELMO1 to the plasma membrane +HIPK2 HIPK2 EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, CMGC; Protein kinase, Ser/Thr (non-receptor) Q9H2X6 28996 7q34 human K32-ub 3059900 FCSVKKLkIEPSSNW protein degradation 18536714 1 0 0 +Mef2d MEF2D DNA-binding; Transcription factor O89038 81518 2q34 rat S153-p 10359102 VPVSNQSsMQFSNPS HJURP_C activity, inhibited apoptosis, altered; transcription, inhibited 19801631 1 0 0 +CTPS1 CTPS EC 6.3.4.2; Ligase; Motility/polarity/chemotaxis; Nucleotide Metabolism - pyrimidine P17812 1503 1p34.2 human T455-p 473570 MRLGKRRtLFQTKNS GATase enzymatic activity, inhibited cell growth, altered 17189248; 17463002 2 0 0 +PSRC1 PSRC1 Q6PGN9 84722 1p13.3 human S223-p 18963101 RAAKLRVsGSGEFVG cytoskeletal reorganization 21473853 1 1 0 +RPS6KA1 p90RSK EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, AGC; Protein kinase, Ser/Thr (non-receptor); Translation Q15418 6195 1p36.11 human K335-sm 1881518211 KLYRREIkPPFKPAV molecular association, regulation; phosphorylation EIF4B(INDUCES) 34871326 1 0 0 SUMO-SIM interaction contributes to RSK1-eIF4B association; sites incudinge IF4B (Ser 422 and Ser 425, 29.91 fold), SETD1A (Ser 915 and Ser 916, 25.76 fold), LMNA (Ser 404 and Ser 406, 16.42 fold), ZNF 217 (Ser 975, 13.27 fold); SUMOylation is required for is required for replication and virus production of KSHV; affect eIF4B phosphorylation by RSK1 in vitro; SUMOylation affects the phosphorylation levels of its substrates +VHL VHL Tumor suppressor; UBIQUITIN LIGASE; Ubiquitin ligase P40337 7428 3p25.3 human K171-sm 13258709 QVVRSLVkPENYRRL VHL_C sumoylation; protein stabilization; molecular association, regulation; intracellular localization cell cycle regulation; carcinogenesis, induced; carcinogenesis, inhibited; cell motility, induced; cell growth, induced; transcription, induced; transcription, inhibited VHL(INDUCES); Alix(INDUCES); VAMP8(INDUCES); TCEB1(DISRUPTS) 20300531; 21652636 2 1 0 +DBN1 DBN1 Actin-binding; Cytoskeletal; Motility/polarity/chemotaxis Q16643 1627 5q35.3 human S142-p 452446 NGLARLSsPVLHRLR molecular association, regulation; intracellular localization cytoskeletal reorganization EB3(INDUCES); PXN(INDUCES); ACTB(INDUCES) 23979715; 24637538; 30467237; 35977504 6 87 28 +FUNDC1 FUNDC1 Membrane protein, multi-pass; Mitochondrial Q8IVP5 139341 Xp11.3 human S13-p 2025373 PPPQDYEsDDDSYEV protein stabilization; molecular association, regulation autophagy, inhibited LC3A(DISRUPTS); LC3B(DISRUPTS); HSC70(DISRUPTS) 24746696; 25126723; 27757847; 30591555 8 24 7 +BRAF BRAF EC 2.7.11.1; KINASE; Kinase, protein; Oncoprotein; Protein kinase, Ser/Thr (non-receptor); Protein kinase, TKL P15056 673 7q34 human S465-p 4959522 TVGQRIGsGSFGTVY PK_Tyr_Ser-Thr molecular association, regulation; activity, inhibited BRAF(DISRUPTS) 31929109 3 6 4 +EGFR EGFR EC 2.7.10.1; KINASE; Kinase, protein; Membrane protein, integral; Oncoprotein; Protein kinase, TK; Protein kinase, tyrosine (receptor) P00533 1956 7p11.2 human K716-ub 1065306 ETEFKKIkVLGSGAF PK_Tyr_Ser-Thr receptor internalization, induced; receptor recycling, inhibited; protein degradation 16543144; 17940017 2 5 0 +PRKD2 PRKD2 EC 2.7.11.13; KINASE; Kinase, protein; Motility/polarity/chemotaxis; Protein kinase, CAMK; Protein kinase, Ser/Thr (non-receptor) Q9BZL6 25865 19q13.32 human Y87-p 178601700 KFPECGFyGLYDKIL intracellular localization cell motility, inhibited; cell adhesion, inhibited 28842658 1 0 0 +NR1I2 PXR DNA-binding; Nuclear receptor O75469 8856 3q13.33 human T408-p 9730704 RSINAQHtQRLLRIQ Hormone_recep protein degradation; molecular association, regulation; intracellular localization autophagy, induced; transcription, inhibited; transcription, altered FGR(INDUCES); N-CoR1(DISRUPTS); RXRA(DISRUPTS) 19617467; 26534988 3 0 0 +HADHA HADHA ACETYLTRANSFERASE; Acetyltransferase; Amino Acid Metabolism - lysine degradation; Amino Acid Metabolism - tryptophan; Amino Acid Metabolism - valine, leucine and isoleucine degradation; Carbohydrate Metabolism - butanoate; Carbohydrate Metabolism - propanoate; EC 1.1.1.211; EC 4.2.1.17; Lipid Metabolism - fatty acid; Lipid Metabolism - fatty acid elongation in mitochondria; Lipid Metabolism - unsaturated fatty acid biosynthesis; Lyase; Mitochondrial; Other Amino Acids Metabolism - beta-alanine; Oxidoreductase; Secondary Metabolites Metabolism - limonene and pinene degradation P40939 3030 2p23.3 human K406-ub 27192523 RGQQQVFkGLNDKVK 3HCDH_N protein degradation; ubiquitination 27457618 1 2 0 +SCN5A SCN5A Channel, sodium; Membrane protein, integral; Membrane protein, multi-pass Q14524 6331 3p22.2 human T594-p 25244201 LHGKKNStVDCNGVV Na_trans_cytopl activity, inhibited 22514276 1 0 0 +Slc12a3 NCCT Membrane protein, integral; Membrane protein, multi-pass; Transporter; Transporter, SLC family P55018 54300 19p13-p12 rat T53-p 469616 GSTLYLRtFGYNTID AA_permease_N activity, induced; ubiquitination; intracellular localization; receptor internalization, inhibited 20445498; 22651238; 22966159; 24668812 25 3 0 ubiquitination reduced +RMDN3 FAM82A2 Apoptosis; Membrane protein, integral; Mitochondrial Q96TC7 55177 15q15.1 human Y176-p 19009800 DAESEGGyTTANAES molecular association, regulation; intracellular localization cell growth, induced; signaling pathway regulation CSK(INDUCES); PKACA(INDUCES); RAF1(DISRUPTS); PTP1B(DISRUPTS); 14-3-3 beta(DISRUPTS); RAF1(INDUCES); 14-3-3 beta(INDUCES); DGKA(DISRUPTS) 21513978; 22544307; 24501773; 31075141 4 0 1 MAPK pathway; inhibits MAPK signaling pathway +IRF1 IRF1 Transcription factor; Tumor suppressor P10914 3659 5q31.1 human S219-p 31839600 FQVSPMPsTSEATTD molecular association, regulation; activity, inhibited transcription, inhibited NFkB-p65(DISRUPTS) 24396068 1 0 0 Phosphorylation impairs iNFkB-p65 interaction and PCAF mediated acetylation K310 -suppression of IFN-beta production +SPAG5 SPAG5 Cell cycle regulation Q96R06 10615 17q11.2 human T978-p 1261101 AEMSIMTtELQSLCS intracellular localization 18055457 1 0 0 required for SPAG5 localization to the spindle apparatus during mitosis +GSK3B GSK3B EC 2.7.11.1; EC 2.7.11.26; KINASE; Kinase, protein; Protein kinase, CMGC; Protein kinase, Ser/Thr (non-receptor) P49841 2932 3q13.33 human K183-ub 63354301 GICHRDIkPQNLLLD Pkinase protein degradation 28298444 1 1 0 negatively regulates anti-inflammatory cytokine production +ATXN7 ataxin-7 Nucleolus; Transcription regulation O15265 6314 3p14.1 human K257-sm 10902804 RIMTPSVkVEKIHPK apoptosis, inhibited 19843541 1 1 0 +RAF1 RAF1 EC 2.7.11.1; KINASE; Kinase, protein; Oncoprotein; Protein kinase, Ser/Thr (non-receptor); Protein kinase, TKL P04049 5894 3p25.2 human S494-p 447745 FGLATVKsRWSGSQQ PK_Tyr_Ser-Thr enzymatic activity, induced 11447113; 12551923; 12865432 5 0 0 +CALD1 Caldesmon Actin-binding Q05682 800 7q33 human S744-p 456707 GLKVGVSsRINEWLT Caldesmon cell motility, altered; cytoskeletal reorganization 16800003; 20128924 5 1 0 +Cttn Cortactin Actin-binding; Cytoskeletal; Motility/polarity/chemotaxis Q60598 13043 7|7 F5 mouse K152-ac 1880005100 TEKHASQkDYSSGFG HS1_rep molecular association, regulation; acetylation; intracellular localization DIP2A(INDUCES) 31600191 1 0 0 DIP2A regulates spine morphology and synaptic transmission through acetylation of cortactin; Interaction of DIP2A-cortactin is required for acetylated cortactin; acetylation mimetic cortactin rescues the repetitive behaviors in Dip2a KO mice; acetylation alleviated abnormal PSD95 clustering at the spine head in DIP2A KO neurons +AR AR DNA-binding; Nuclear receptor; Transcription factor P10275 367 Xq12 human Y365-p 478251 AYQSRDYyNFPLALA Androgen_recep transcription, induced; cell growth, altered 17494760 3 2 0 +SUPT16H SPT16 Transcription initiation complex Q9Y5B9 11198 14q11.2 human K674-ac 474904 IRPNIAQkRMQGSLE SPT16 protein stabilization; molecular association, regulation BRD4(INDUCES) 35904816 1 3 50 SPT16H?BRD4 interacts with HDAC1 and EZH2 contributing to gene silencing, IFN signaling via epigenetic suppression +ERBB3 HER3 EC 2.7.10.1; KINASE; Kinase, protein; Membrane protein, integral; Oncoprotein; Protein kinase, TK; Protein kinase, tyrosine (receptor) P21860 2065 12q13.2 human Y1262-p 3971613 TPDEDYEyMNRQRDG molecular association, regulation GRB2(INDUCES); GRB7(INDUCES) 16729043; 9516479 2 1 2 Grb2 binding is reduced campared with Grb7. +NOVA2 NOVA2 Q9UNW9 4858 19q13.32 human T27-p 1869341902 VCTKRSNtGEEGEYF intracellular localization 32492405 1 1 0 Phosphorylated NOVA2 translocates to cytosol leading to reduced E29 inclusion in BK channel and thereby inhibiting BK channel activity. +Glp1r GLP1R GPCR, family 2; Membrane protein, integral; Membrane protein, multi-pass; Receptor, GPCR P32301 25051 20p12 rat S442-p 451371 PLKCPTSsVSSGATV receptor desensitization, altered 8702711 1 0 0 +KAT5 Tip60 ACETYLTRANSFERASE; Acetyltransferase; EC 2.3.1.48; Nuclear receptor co-regulator; Nucleolus Q92993 10524 11q13.1 human Y294-p 29431804 HPPGNEIyRKGTISF MOZ_SAS molecular association, regulation; acetylation; intracellular localization; enzymatic activity, inhibited cell cycle regulation; apoptosis, induced Fe65(INDUCES) 24044023 1 0 0 +USF1 USF1 DNA-binding; Transcription factor P22415 7391 1q23.3 human K199-ac 7652100 PRTTRDEkRRAQHNE molecular association, regulation transcription, inhibited DNA(INDUCES) 19389701 1 0 0 +HNRNPU hnRNP U DNA-binding; Nuclear receptor co-regulator; RNA splicing; RNA-binding; Spliceosome Q00839 3192 1q44 human S59-p 468001 AMEPGNGsLDLGGDS molecular association, regulation; intracellular localization cell cycle regulation; DNA repair, induced NEIL1(DISRUPTS); Ku70(INDUCES) 25986610; 27303920 4 62 7 transient dissociation of NEIL1 from chromatin; localizes to centrosomes, the midzone and the midbody in mitosis +PCNA PCNA Cell cycle regulation; DNA replication P12004 5111 20p12.3 human Y250-p 231166701 DMGHLKYyLAPKIED PCNA_C ubiquitination cell cycle regulation 28924044 1 1 0 +Cdkn2c CDKN2C Cell cycle regulation; Inhibitor; Protein kinase, regulatory subunit Q60772 12580 4 C7|4 51.32 cM mouse K112-ub 6423505 LPLHLAAkEGHLPVV Ank_2 protein degradation 19029828 1 0 0 +ABI1 Abi-1 Adaptor/scaffold; Motility/polarity/chemotaxis Q8IZP0 10006 10p12.1 human S410-p 12626407 DIPMFDDsPPPPPPP molecular association, regulation cell motility, altered; cytoskeletal reorganization 21419341 1 1 0 regulates WRC (WAVE2 regulatory complex) interaction with Arp2/3 and lamellipodial protrusion +Smad3 SMAD3 DNA-binding; Nuclear receptor co-regulator; Transcription factor Q8BUN5 17127 9|9 C mouse S309-p 1243501 EVFAECLsDSAIFVQ MH2 activity, induced; intracellular localization 17991884 2 1 0 Nuclear translocation +Ikbkg IKKG Adaptor/scaffold; Protein kinase, regulatory subunit O88522 16151 X|X A7.3 mouse K270-sm 2255104 AEEALVAkQELIDKL CC2-LZ molecular association, regulation; intracellular localization; phosphorylation transcription, induced; signaling pathway regulation CYLD(DISRUPTS) 23825957; 26596471 6 0 0 induces p65 phosphorylation, induces IKK/NF-KB signaling; induces phosphorylation of IKB-alpha, NF-kB p65, nuclear translocation of p65, thus inducing NF-kB signaling +PLAU uPA EC 3.4.21.73; Motility/polarity/chemotaxis; Protease; Secreted; Secreted, signal peptide P00749 5328 10q22.2 human S158-p 451052 CADGKKPsSPPEELK molecular association, regulation; intracellular localization; activity, inhibited cell motility, altered; cell adhesion, altered; cytoskeletal reorganization ITGA5(INDUCES); ITGB5(INDUCES) 18844213; 9151681; 9765311 3 0 0 S158 phosphorylation confers to prourokinase the antagonistic properties; reduces ITGB5/ITGA5 activation and its interaction with vitronectin and talin; ligand-dependent uPA redistribution severely impaired in a S158/323E mutant +F2R PAR1 Cell development/differentiation; GPCR, family 1; Membrane protein, integral; Membrane protein, multi-pass; Receptor, GPCR P25116 2149 5q13.3 human S392-p 3627503 ILCCKESsDPSSYNS receptor desensitization, altered 10413505 1 0 0 receptor shutoff (not internalization) +RAF1 RAF1 EC 2.7.11.1; KINASE; Kinase, protein; Oncoprotein; Protein kinase, Ser/Thr (non-receptor); Protein kinase, TKL P05625 396245 chicken Y340-p 447749 RGQRDSSyYWEIEAS enzymatic activity, induced apoptosis, inhibited 12843393; 12952943 29 1 1 +Mapk1 ERK2 EC 2.7.11.24; KINASE; Kinase, protein; Protein kinase, CMGC; Protein kinase, Ser/Thr (non-receptor) P63086 116590 11q23 rat T179-p 3189583 ADPDHDHtGFLTEYV Pkinase enzymatic activity, induced translation, altered 15757502 4 12 40 phenylphrine induces protein synthesis +Prkra PACT Activator; RNA processing; RNA-binding Q9WTX2 23992 2|2 C3 mouse S18-p 453415 PPLQREDsGTFSLGK molecular association, regulation; phosphorylation translation, altered; cell growth, inhibited; apoptosis, induced PKR(INDUCES) 15299031; 16574643; 16861340 3 63 135 +Sarm1 SARM1 D3ZUM2 287545 rat S548-p 4739912 AAREMLHsPLPCTGG intracellular localization 32968873 3 9 3 stimulates protein oligomerization; regulation of axonal degenearion and mitochondrial transport +CDC73 CDC73 Cell cycle regulation; Tumor suppressor Q6P1J9 79577 1q31.2 human K243-ub 603484760 TILQSTGkNFSKNIF CDC73_N protein degradation; ubiquitination 35551175 1 2 0 +ENOX2 ENOX2 Cell surface; Cytoskeletal; EC 1.-.-.-; Oxidoreductase Q16206 10495 Xq26.1 human S504-p 25602101 ENLKEKEsCASRLCA protein stabilization cell motility, induced; cell growth, induced 22659163 1 0 0 +Tgif1 TGIF DNA-binding; Nuclear receptor co-regulator; Transcription, coactivator/corepressor P70284 21815 17|17 E1.3 mouse T239-p 1868546603 LFNTPPPtPPDLNQD molecular association, regulation carcinogenesis, induced; cell growth, induced; transcription, induced; signaling pathway regulation TWIST1(INDUCES); TWIST1(DISRUPTS) 31152009; 31268604 2 0 0 TGIF T239D/T235D mutant does not inhibit TWIST1 expression; in Kras active mutant cells; TGIF T239D/T235D mutant stimulates proliferation of Capan-2 cells +ABCF1 ABCF1 RNA-binding; Translation Q8NE71 23 6p21.33 human S140-p 454452 AALIQDQsEEEEEEE molecular association, regulation 17894550 1 62 8 S109 aqnd S140 phosphorylation may affect ABCF1-eIF2 binding to 60S 80S subunits and small polysomes. +AHSG FETUA Secreted; Secreted, signal peptide P02765 197 3q27.3 human S330-p 467425 VVSLGSPsGEVSHPR activity, inhibited 31084489 3 23 13 Inhibits insulin-induced GLUT4 translocation, glucose uptake/glycogen synthesis +PTK2 FAK EC 2.7.10.2; KINASE; Kinase, protein; Protein kinase, TK; Protein kinase, tyrosine (non-receptor) Q05397 5747 8q24.3 human S910-p 447964 KLQPQEIsPPPTANL molecular association, regulation carcinogenesis, induced; cytoskeletal reorganization; cell adhesion, altered; cell adhesion, inhibited; cell growth, altered ITGB3(INDUCES); P130Cas(DISRUPTS); talin 1(DISRUPTS) 17692050; 20519501; 33999101 20 48 0 regulates FA turnover, ECM degradation, and metastasis +INVS INVS Q9Y283 27130 9q31.1 human T866-p 55578723 ARRLETStLSEDFQV cytoskeletal reorganization 27220846 1 0 0 Akt2 plays a more prominent role in ciliary development than Akt1, tubular differentiation +Syn1 SYN1 Vesicle O88935 20964 X A1.3|X 16.37 cM mouse S553-p 448377 ARPPASPsPQRQAGA cytoskeletal reorganization; signaling pathway regulation 25463523; 30016727 8 22 10 protects against ischemic injury and cell death; OGD induces morphological damage of neurites in cortical neurons; multiple signaling pathways converge onto SynI and regulated by phosphorylation, hippocampal-dependent learning de?cits +DMD dystrophin Cytoskeletal; Motility/polarity/chemotaxis P11532 1756 Xp21.2-p21.1 human S3066-p 35542205 GPWERAIsPNKVPYY WW protein stabilization; molecular association, regulation cytoskeletal reorganization DAG1(INDUCES) 25082828 2 1 0 +Myrf MRF DNA-binding; Membrane protein, integral Q3UR85 225908 19|19 A mouse S259-p 20804942 PSKKRKHsESPPNTL molecular association, regulation transcription, inhibited Huntingtin(INDUCES) 32270922 1 2 0 induces demyelination +aurka AurA EC 2.7.11.1; KINASE; Kinase, protein; Oncoprotein; Protein kinase, Other; Protein kinase, Ser/Thr (non-receptor) Q91820 397925 frog T295-p 448784 APSSRRTtLCGTLDY Pkinase enzymatic activity, induced 12422018 66 12 7 +G6PD G6PD Carbohydrate Metabolism - pentose phosphate pathway; Cell development/differentiation; EC 1.1.1.49; Other Amino Acids Metabolism - glutathione; Oxidoreductase P11413 2539 Xq28 human K403-ac 11320991 PNEAVYTkMMTKKPG G6PD_C protein degradation; molecular association, regulation; enzymatic activity, inhibited; protein conformation; enzymatic activity, altered carcinogenesis, inhibited; cell growth, inhibited; apoptosis, induced p53(INDUCES); G6PD(DISRUPTS) 24769394; 27586085; 35065072; 37798264 4 3 3 induction of apoptotic signaling; negatively regulates dimerization; reshaped the dimer interface and propagated to the substrate binding +GMNN Geminin Cell cycle regulation; Motility/polarity/chemotaxis O75496 51053 6p22.3 human K127-ub 573758968 LHKEIEQkDNEIARL Geminin molecular association, regulation CDT1(DISRUPTS) 34599168 1 2 0 inhibits MCM proteins binding to Cdt1; cancer-derived SPOP mutants increase replication origin ?ring, re-replication, and genome instability, increased by ATR inhibition +Grik5 GluR KA2 Channel, ligand-gated; Membrane protein, integral; Membrane protein, multi-pass Q63273 24407 1q21 rat S836-p 31033002 STRRSAEsEEVSVCQ activity, induced 23066089 1 0 0 GluR KA2 mediated potentiation of heteromeric KARs +Plk1 PLK1 EC 2.7.11.21; KINASE; Kinase, protein; Protein kinase, Other; Protein kinase, Ser/Thr (non-receptor) Q07832 18817 7 F2|7 65.52 cM mouse Y445-p 54066601 DSTRLILyNDGDSLQ POLO_box enzymatic activity, induced cell cycle regulation 26755576 3 1 0 +NPM/ALK NPM-ALK KINASE; Kinase, protein; Protein kinase, TK; Protein kinase, tyrosine (receptor) AAA58698 human S497-p 27275105 AKREEERsPAAPPPL phosphorylation carcinogenesis, altered; cell growth, altered 21045017 1 1 0 +Prkn PARK2 EC 6.3.2.-; EC 6.3.2.19; Ligase; Translation; Translation regulation; UBIQUITIN LIGASE; Ubiquitin conjugating system; Ubiquitin ligase Q9WVS6 50873 17 A1|17 7.8 cM mouse S9-p 11096954 IVFVRFNsSYGFPVE ubiquitin molecular association, regulation; ubiquitination; intracellular localization; phosphorylation carcinogenesis, inhibited; signaling pathway regulation RIPK3(INDUCES) 31358971 3 1 1 binds to RIPK3 disrupting RIPK3-RIPK1 binding, induces RIPK3 ubiquitination, inhibits RIPK3 and MLKL phosphorylation, regulates RIPK3 localization, induces Parkin-RIPK3 pathway +ANXA2 ANXA2 Calcium-binding; Lipid-binding; Motility/polarity/chemotaxis P04272 282689 cow Y24-p 449483 HSTPPSAyGSVKAYT intracellular localization exocytosis, induced; cytoskeletal reorganization 32917016 29 64 2613 +Gabbr1 GABBR1 GPCR, family 3; Membrane protein, integral; Membrane protein, multi-pass; Receptor, GPCR Q9Z0U4 81657 20p12 rat K923-ub 7251351 EKSRLLEkENRELEK receptor recycling, inhibited; protein degradation; intracellular localization 27573246 2 1 2 +H3C14 HIST2H3A/C/D DNA-binding Q71DI3 126961 1q21.2 human K79-m2 18465106 REIAQDFkTDLRFQS Histone molecular association, regulation L3MBTL iso4(INDUCES) 23583077 0 3 2 +BAIAP2L1 IRTKS Adaptor/scaffold; Cytoskeletal Q9UHR4 55971 7q21.3-q22.1 human S331-p 2509171 PSLQRSVsVATGLNM molecular association, regulation p53(DISRUPTS) 28647685 1 28 12 +Slc1a2 GLT1 Membrane protein, integral; Membrane protein, multi-pass; Transporter; Transporter, SLC family P43006 20511 2 E2|2 54.13 cM mouse S562-p 486052 NGKSADCsVEEEPWK intracellular localization; activity, inhibited 34516830 1 6 0 +SRF SRF Motility/polarity/chemotaxis; Transcription factor P11831 6722 6p21.1 human S85-p 451801 GSEGDSEsGEEEELG molecular association, regulation DNA(INDUCES) 1547771 3 5 0 +Kirrel2 KIRREL2 Cell adhesion; Membrane protein, integral Q7TSU7 243911 7|7 B1 mouse Y596-p 50247600 KDPTNGYyRVRGVSV protein processing; intracellular localization 26324709 1 1 0 +HIF1A HIF1A Autophagy; DNA-binding; Transcription factor Q16665 3091 14q23.2 human T63-p 56589703 KASVMRLtISYLRVR protein stabilization transcription, induced 27245613; 27245614 2 2 0 +Hsf1 HSF1 DNA-binding; Transcription factor P38532 15499 15 D3|15 35.95 cM mouse S307-p 449046 EPPSPPHsPRVLEAS Vert_HS_TF activity, inhibited transcription, inhibited; transcription, altered 11162511; 28724629; 33846884 26 56 3 +Dnm1 DYN1 EC 3.6.5.5; Hydrolase; Microtubule-binding; Motility/polarity/chemotaxis; Motor; Vesicle P39053 13429 2 B|2 22.09 cM mouse S774-p 450205 SVPAGRRsPTSSPTP molecular association, regulation endocytosis, inhibited ITSN1(DISRUPTS) 29199069 14 34 21 peptide interferes with VGLUT1 binding to ITSN1; diurnal variations in the phosphorylation +KCNJ1 ROMK Channel, potassium; Membrane protein, integral; Membrane protein, multi-pass P48048 3758 11q24.3 human T193-p 2813503 KKRAKTItFSKNAVI IRK_C molecular association, regulation; activity, inhibited ROMK(DISRUPTS) 22139477 2 0 0 regulates pH sensitivity of the channel +YES1 Yes EC 2.7.10.2; KINASE; Kinase, protein; Oncoprotein; Protein kinase, TK; Protein kinase, tyrosine (non-receptor) P07947 7525 18p11.32 human Y537-p 447620 FTATEPQyQPGENL_ enzymatic activity, inhibited carcinogenesis, inhibited; cell growth, inhibited; apoptosis, induced 12640114; 35041461 5 23 1248 +KMT2D MLL4 iso3 EC 2.1.1.43; METHYLTRANSFERASE; Methyltransferase; Methyltransferase, protein lysine; Nuclear receptor co-regulator; Transcription regulation O14686-3 8085 12q13.12 human S1331-p 1217705 RGRARLKsTASSIET molecular association, regulation; methylation; activity, inhibited transcription, inhibited; signaling pathway regulation DNA(DISRUPTS) 30943409 1 1 5 regulates H3 K4 me1/2 +Tlr2 TLR2 Apoptosis; Cell surface; Membrane protein, integral; Motility/polarity/chemotaxis; Receptor, misc. Q9QUN7 24088 3|3 E3 mouse Y647-p 1876860404 CYDAFVSySEQDSHW TIR activity, induced; protein stabilization; molecular association, regulation; ubiquitination transcription, induced SH3BP2(INDUCES); PPP1R11(DISRUPTS); MYD88(INDUCES) 35362478 1 0 0 inhibits ubiquitination +RELA NFkB-p65 DNA-binding; Nuclear receptor co-regulator; Transcription factor Q04206 5970 11q13.1 human S529-p 447799 GLPNGLLsGDEDFSS activity, induced; intracellular localization cell cycle regulation; carcinogenesis, induced; cell growth, induced; apoptosis, inhibited; transcription, induced; transcription, altered 11259436; 12444159; 14963024; 26082493; 33676898; 36035991 27 3 1 +MAP4 MAP4 Cytoskeletal; Motility/polarity/chemotaxis P27816 4134 3p21.31 human S696-p 449564 PNKELPPsPEKKTKP cytoskeletal reorganization 25746230 3 44 1 promotes microtubule depolymerization, induces vascular permeability and dysfunction of endothelial barrier. +PAPOLA PAP-alpha EC 2.7.7.19; RNA processing; RNA splicing; Transferase P51003 10914 14q32.2 human K445-sm 2586345 VIGLVFKkTENSENL protein stabilization; enzymatic activity, inhibited 18281463 1 0 0 +Mtss1 MTSS1 Adaptor/scaffold; Motility/polarity/chemotaxis; Tumor suppressor Q8R1S4 211401 15|15 D1 mouse Y397-p 463827 HLPDYAHyYTIGPGM cytoskeletal reorganization 17224454 1 1 6 +Tet2 TET2 EC 1.14.11.n2; Oxidoreductase; Tumor suppressor Q4JK59 214133 3|3 G3 mouse S97-p 3202572 GGIKRTVsEPSLSGL protein stabilization; molecular association, regulation; ubiquitination cell differentiation, induced; transcription, induced 14-3-3 beta(INDUCES) 31164154 3 17 5 inhibits ubiquitination, induces transcription of differentiation related genes +Dab1 DAB1 iso2 Adaptor/scaffold Q6XBN7 chicken S475-p 479422 TPAPRQSsPSKSSAS protein degradation; ubiquitination 21111810 7 0 0 +FGF1 FGF1 Cell development/differentiation; Cytokine; Motility/polarity/chemotaxis P05230 2246 5q31.3 human S131-p 31954800 VGLKKNGsCKRGPRT FGF intracellular localization apoptosis, altered; apoptosis, induced; signaling pathway regulation 24595027; 26844696; 27773526; 29048426 4 0 0 inhibits p53-dependent anti-apoptotic activity; nuclear export; Inhibits FGF1 anti-apoptotic activity.; S131R mutation shows reduction in mitogenic stimulation, increase in ?broblast growth factor receptor-1c activation, and prolonged duration of glucose lowering in ob/ob hyperglycemic mice. +STRAP STRAP Adaptor/scaffold; RNA splicing; UBIQUITIN LIGASE; Ubiquitin ligase Q9Y3F4 11171 12p12.3 human T175-p 11267002 LWDHATMtEVKSLNF phosphorylation apoptosis, altered 19880523 2 1 0 negatively regulates ASK1 phosphorylation and ASK1-mediated signaling +Cacng2 Stargazin Channel, calcium; Membrane protein, integral; Membrane protein, multi-pass O88602 12300 15 E1|15 36.92 cM mouse S241-p 455317 QRRSRSSsRSTEPSH activity, induced; intracellular localization 15664178; 20670832 3 0 0 AMPAR immobilization in synaptic membrane; enhances AMPA receptor responses and is required for long-term potentiation +USP21 USP21 DEUBIQUITINASE; EC 3.4.19.12; Protease; Ubiquitin conjugating system; Ubiquitin-specific protease Q9UK80 27005 1q23.3 human S538-p 63253102 VYNDSRVsPVSENQV UCH molecular association, regulation STING(INDUCES) 28254948 1 1 0 +GLI3 GLI3 C2H2-type zinc finger protein; Transcription factor P10071 2737 7p14.1 human K784-ub 6097709 HVKLERLkQVNGMFP protein processing 16705181 1 0 0 +RPL23A RPL23A Ribosomal; Translation P62750 6147 17q11.2 human K89-ub 1884021301 TTESAMKkIEDNNTL protein degradation; ubiquitination transcription, altered 35637966 1 1 0 HERC3 could control protein expression and ubiquitination of c-Myc/p21 via RPL23A +H4C1 H4 DNA-binding P62805 8359 6p22.2 human R17-m1 1873284318 LGKGGAKrHRKVLRD CENP-T_C methylation 28874563 1 0 0 increases R3 monomethylation by PRMT1 and PRMT5 +Kif17 KIF17 Microtubule-binding; Motor Q99PW8 16559 4|4 D3 mouse S1029-p 1720900 SKAKRKKsKNSFGGE molecular association, regulation; intracellular localization; activity, inhibited endocytosis, induced APBA1(DISRUPTS) 18066053; 24931613; 30458707 3 0 0 Phosphorylation disrupts KIF17 interaction with its cognate cargo. and reduces post-ER trafficking in neurons.; Promotes cell-autonomous disc shedding and phagocytosis of outer segments +CDC25A CDC25A EC 3.1.3.48; Motility/polarity/chemotaxis; PHOSPHATASE; Protein phosphatase, dual-specificity P30304 993 3p21.31 human S321-p 472278 QSLSLASsPKGTIEN M-inducer_phosp protein degradation; ubiquitination cell cycle regulation; apoptosis, inhibited 34363019 2 3 0 +HTT Huntingtin Cytoskeletal P42858 3064 4p16.3 human S534-p 465626 EDILSHSsSQVSAVP protein stabilization 16782707 0 1 0 reduces cellular toxicity +Esyt1 ESYT1 Membrane protein, integral; Membrane protein, multi-pass Q3U7R1 23943 10|10 D3 mouse S314-p 15409842 QDVAQLRsPLPRGII molecular association, regulation GLUT4(INDUCES) 19255425 1 1 3 activates insulin-dependent glucose uptake +Gab1 GAB1 Adaptor/scaffold; Motility/polarity/chemotaxis Q9QYY0 14388 8|8 C2 mouse Y628-p 447948 KGDKQVEyLDLDLDS molecular association, regulation; enzymatic activity, induced cell motility, induced; apoptosis, inhibited; signaling pathway regulation SHP-2(INDUCES) 28365441; 33786575 24 25 438 FoxO1-GAB1-pAKT signaling +CSF2RB CSF2RB Membrane protein, integral; Receptor, cytokine P32927 1439 22q12.3 human Y766-p 450104 VKSGFEGyVELPPIE activity, induced; molecular association, regulation apoptosis, altered; signaling pathway regulation; transcription, altered; cell growth, altered LYN(INDUCES); GRB2(INDUCES); SHC1(INDUCES) 10329850; 10672044; 10704825; 22177802; 8752899; 9257712 6 1 9 induces JAK/STAT signaling; Phosphorylation of Y628, Y711, or Y766 is necessary and sufficient for STAT activation by IL-5. +Eif2b5 eIF2B-epsilon Translation; Translation initiation Q64350 192234 11q23 rat S712-p 449907 LREAEEEsSDDD___ W2 molecular association, regulation eIF2-alpha(INDUCES) 11500362 3 10 2 +PA2G4 Ebp1 Nuclear receptor co-regulator; Nucleolus; Transcription, coactivator/corepressor Q9UQ80 5036 12q13.2 human K93-sm 11539305 VCHFSPLkSDQDYIL Peptidase_M24 sumoylation; protein stabilization; intracellular localization carcinogenesis, inhibited; cell growth, inhibited; transcription, inhibited 19946338 1 0 0 mutation of either site abolishes sumoylation at other site +MRE11 MRE11A Cell cycle regulation; DNA repair, damage; DNA-binding; Deoxyribonuclease P49959 4361 11q21 human R592-m2 62978408 ASRGGSQrGRADTGL DNA repair, altered 15741314 0 1 0 +Fndc5 FNDC5 Membrane protein, integral Q8K4Z2 384061 4|4 D2.2 mouse K131-ac 5895766 EAEKMASkNKDEVTM ubiquitination 33754067 1 0 1 SIRT2-dependent deacetylation and deubiquitination increases stability +CASP2 CASP2 Apoptosis; EC 3.4.22.55; Protease P42575 835 7q34 human K77-sm 12004434 MRELIQAkVGSFSQN CARD intracellular localization; enzymatic activity, induced 15882978 1 0 0 maturation of procaspase-2 +ANXA1 ANXA1 Calcium-binding; Lipid-binding P04083 301 9q21.13 human S45-p 9730700 PYPTFNPsSDVAALH intracellular localization exocytosis, altered 19625660 1 1 0 S27A or S45A mutations prevented translocation of ANXA1 to the plasma membrane and stimulated ACTH release +SNAI2 Snail2 Apoptosis; C2H2-type zinc finger protein; Motility/polarity/chemotaxis; Transcription factor O43623 6591 8q11.21 human S96-p 25603908 PPPSDTSsKDHSGSE protein degradation; intracellular localization cell motility, inhibited; transcription, induced CHIP(INDUCES) 22727060; 23851495 2 1 0 WT localizes in cytosol and nucleus; transcriptional activity of E-cadherin; Snail2 luciferase construct, may affect lung metastasis in NSCLC.; WT localized in nucleus and cytoplasm, mutants localize in nucleus; mutants enhance epithelial-mesenchymal transition (EMT) +Elk4 ELK4 DNA-binding; Transcription, coactivator/corepressor P41158 13714 1|1 E4 mouse S380-p 4317600 IHFWSTLsPFAPLSP cell growth, altered 18356083 2 0 0 pro-B cell expansion +IRS4 IRS4 Adaptor/scaffold O14654 8471 Xq22.3 human Y921-p 456294 EADSSSDyVNMDFTK molecular association, regulation cell cycle regulation; carcinogenesis, induced; cell growth, induced GRB2(INDUCES); PLCG1(INDUCES); EBNA1BP2(INDUCES); PIK3R1(INDUCES) 15316024; 35550247 1 6 14 +CHFR CHFR EC 6.3.2.-; EC 6.3.2.19; Ligase; UBIQUITIN LIGASE; Ubiquitin conjugating system; Ubiquitin ligase Q96EP1 55743 12q24.33 human K393-ub 25090300 TQDMLQPkVRRSFSD protein degradation cell cycle regulation 21768102 1 0 0 auto-ubiquitylation and CHFR degradation regulate the G2/M transition +GCM1 GCM1 DNA-binding; Transcription factor Q9NP62 8521 6p12.1 human S275-p 18788304 LSSSRTYsSGDLLPP protein stabilization; molecular association, regulation; acetylation transcription, induced DUSP23(INDUCES) 20855292; 26503785 2 0 0 +Irs2 IRS2 Adaptor/scaffold; Motility/polarity/chemotaxis P81122 384783 8 A1.1|8 5.35 cM mouse S723-p 3217368 GGGYKASsPAESSPE signaling pathway regulation 23359250; 24614172; 31672472 9 15 4 insulin-dependent signaling pathway +MALT1 MALT1 Adaptor/scaffold; Apoptosis; EC 3.4.22.-; Ligase; Nuclear export; Protease; UBIQUITIN LIGASE; Ubiquitin conjugating system Q9UDY8 10892 18q21.32 human K661-ub 2134704 TGSYLVSkDLPKHCL MALT1_Ig protein degradation; molecular association, regulation IKKA(INDUCES) 17948050 1 1 0 activation of NF-kB pathway and IL-2 induction +RUNX3 AML2 DNA-binding; Transcription factor Q13761 864 1p36.11 human T231-p 471996 HFSSQPQtPIQGTSE protein degradation; molecular association, regulation; ubiquitination; activity, inhibited carcinogenesis, induced PIN1(INDUCES) 22580604 1 5 21 The downstream effects occur in the presence of PIN1 +PPARGC1A PGC-1 alpha Nuclear receptor co-regulator; Transcription, coactivator/corepressor Q9UBK2 10891 4p15.2 human S571-p 2045307 RMRSRSRsFSRHRSC activity, inhibited 19915805 4 0 0 +Tbk1 TBK1 EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, Other; Protein kinase, Ser/Thr (non-receptor) Q9WUN2 56480 10|10 D2 mouse Y179-p 23151249 SLYGTEEyLHPDMYE Pkinase phosphorylation signaling pathway regulation 30514903 3 1 4 Y188/199 of IKK? and Y179 TBK1 phosphorylation induce activation of TLR signaling +Skp2 SKP2 Cell cycle regulation; UBIQUITIN LIGASE; Ubiquitin conjugating system; Ubiquitin ligase Q9Z0Z3 27401 15|15 A1 mouse K71-ac 25673100 SPPRKRVkGKGSDKD protein stabilization; intracellular localization carcinogenesis, induced; cell motility, induced 22770219 2 0 0 Skp2 cytoplasmic localization +CDK7 CDK7 Cell cycle regulation; EC 2.7.11.22; EC 2.7.11.23; KINASE; Kinase, protein; Nuclear receptor co-regulator; Protein kinase, CMGC; Protein kinase, Ser/Thr (non-receptor) P50613 1022 5q13.2 human T170-p 448306 GSPNRAYtHQVVTRW Pkinase protein conformation; enzymatic activity, induced cell cycle regulation; cell growth, induced; cytoskeletal reorganization; transcription, altered 32855301; 35337817; 9832506 5 71 91 +Gata4 GATA4 Motility/polarity/chemotaxis; Transcription factor Q08369 14463 14 D1|14 33.24 cM mouse K320-ac 18380902 GIQTRKRkPKNLNKS cell growth, induced; transcription, induced 20833366 1 0 0 +NEDD4 NEDD4 iso4 EC 6.3.2.-; EC 6.3.2.19; Ligase; Nuclear receptor co-regulator; UBIQUITIN LIGASE; Ubiquitin conjugating system; Ubiquitin ligase P46934-4 4734 15q21.3 human K667-ac 1881518202 FYKMMLHkPITLHDM molecular association, regulation; ubiquitination; intracellular localization matrix protein VP40(INDUCES) 34111220 1 1 0 VP40 VLP production, release of VP40 VLPs, acetylation enhances VP40 ubiquitination, alters VP40 intracellular localization +RAD52 RAD52 DNA repair, damage P43351 5893 12p13.33 human K286-ac 54247385 VSTPSAEkSEAAPPA molecular association, regulation; intracellular localization DNA repair, induced RFA2(INDUCES); RPA3(INDUCES); RAD51(INDUCES); RPA1(INDUCES) 29590107 1 1 0 accumulation of RAD52 at DSB sites +SQSTM1 SQSTM1 Autophagy; Nuclear receptor co-regulator; Ubiquitin conjugating system Q13501 8878 5q35.3 human T350-p 34735619 SKEVDPStGELQSLQ molecular association, regulation; intracellular localization transcription, induced KEAP1(INDUCES) 34774801 1 1 1 regulates NRF2 localization +Kdr VEGFR2 EC 2.7.10.1; KINASE; Kinase, protein; Membrane protein, integral; Protein kinase, TK; Protein kinase, tyrosine (receptor) P35918 16542 5 C3.3|5 40.23 cM mouse S982-p 10940352 FVEEKSLsDVEEEEA PK_Tyr_Ser-Thr receptor internalization, induced; protein degradation 35288568 1 3 0 +TAB1 TAB1 Activator; Motility/polarity/chemotaxis Q15750 10454 22q13.1 human T431-p 456223 ASTLDEAtPTLTNQS activity, inhibited; phosphorylation 15590691; 19393267 5 0 1 inhibits phosphorylation of TAK1; inhibits TAK1 T187 phosphorylation +Tcf7l2 TCF7L2 Apoptosis; Cell cycle regulation; Cell development/differentiation; DNA-binding; Motility/polarity/chemotaxis; Transcription factor Q924A0 21416 19 D2|19 51.59 cM mouse K297-sm 2407415 AIVTPTVkQESSQSD intracellular localization transcription, induced 12727872 1 0 0 +G3BP1 G3BP-1 Adaptor/scaffold; EC 3.6.4.12; EC 3.6.4.13; Helicase; RNA-binding Q13283 10146 5q33.1 human S232-p 449042 EDAQKSSsPAPADIA molecular association, regulation; protein conformation G3BP-1(DISRUPTS) 12642610; 32302572 7 104 29 +MAPKAPK2 MAPKAPK2 EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, CAMK; Protein kinase, Ser/Thr (non-receptor) P49137 9261 1q32.1 human S272-p 448268 SNHGLAIsPGMKTRI Pkinase activity, induced 8846784 1 0 0 +RB1 Rb Nuclear receptor co-regulator; Oncoprotein; Transcription, coactivator/corepressor; Tumor suppressor P06400 5925 13q14.2 human T356-p 447981 DSFETQRtPRKSNLD molecular association, regulation carcinogenesis, induced; cell growth, induced; apoptosis, inhibited E2F1(DISRUPTS) 20223825; 22279936; 26265441 15 19 36 +NUPR1 NUPR1 Apoptosis; Cell cycle regulation; Cell development/differentiation O60356 26471 16p11.2 human K77-ac 465464 LQNSERKkRGARR__ Phospho_p8 intracellular localization 16294328 1 0 0 regulates nuclear transport +Coro1b coronin 1B Actin-binding; Motility/polarity/chemotaxis Q9WUM3 23789 19 A|19 3.85 cM mouse S2-p 456131 ______MsFRKVVRQ intracellular localization exocytosis, altered; cytoskeletal reorganization 21844203 7 0 0 inhibits MC (mast cells) degranulation +Zfpm2 FOG2 C2H2-type zinc finger protein; Nuclear receptor co-regulator Q8CCH7 22762 15 B3.1|15 15.74 cM mouse K915-sm 1873213006 SFERNMIkCEKNGNP molecular association, regulation transcription, induced GATA4(DISRUPTS) 23226341 1 0 0 desumoylation induces repression +PDHA1 PDHA1 Amino Acid Metabolism - valine, leucine and isoleucine biosynthesis; Carbohydrate Metabolism - butanoate; Carbohydrate Metabolism - citrate (TCA) cycle; Carbohydrate Metabolism - glycolysis and gluconeogenesis; Carbohydrate Metabolism - pyruvate; EC 1.2.4.1; Mitochondrial; Oxidoreductase P08559 5160 Xp22.12 human S295-p 468391 RYHGHSMsDPGVSYR E1_dh enzymatic activity, induced carcinogenesis, induced; apoptosis, inhibited 33022274 3 51 241 +IRS1 IRS1 Adaptor/scaffold; Motility/polarity/chemotaxis P35568 3667 2q36.3 human Y896-p 447556 EPKSPGEyVNIEFGS activity, induced; molecular association, regulation; phosphorylation cell cycle regulation GRB2(INDUCES) 11259577; 22081023 13 2 0 regulation of glucose metabolism; Erk1/2 phosphorylation +GLI1 GLI1 C2H2-type zinc finger protein; Oncoprotein; Transcription factor P08151 2735 12q13.3 human S201-p 1034327200 PLEGDMSsPNSTGIQ molecular association, regulation; intracellular localization transcription, inhibited SUFU(INDUCES) DNA(DISRUPTS) 29662197 1 0 0 localized in cytoplasm +Nfil3 E4BP4 DNA-binding; Transcription factor O08750 18030 13 B1|13 27.68 cM mouse S286-p 3197462 EGVVGKSsDGEDEQQ Vert_IL3-reg_TF transcription, inhibited 29311361 1 6 0 NK cell production inhibited +PRKN PARK2 EC 6.3.2.-; EC 6.3.2.19; Ligase; Translation; Translation regulation; UBIQUITIN LIGASE; Ubiquitin conjugating system; Ubiquitin ligase O60260 5071 6q26 human S127-p 1876336800 AVILHTDsRKDSPPA enzymatic activity, inhibited carcinogenesis, induced; cell growth, induced; translation, induced 35191952 1 0 0 inhibits elF4B ubiquitination and degradation +PYHIN1 PYHIN1 Tumor suppressor Q6K0P9 149628 1q23.1 human K138-ac 1881258603 EETLGPQkRKKPSEE intracellular localization 34156286 1 1 0 induces partial cytoplasmic localization +FANCD2 FANCD2 DNA repair, damage Q9BXW9 2177 3p25.3 human T691-p 470035 YGLEEYDtQDGIAIN FancD2 activity, induced cell cycle regulation 16943440 1 2 2 promotes monoubiquitination of FANCD2 +BECN1 beclin 1 Adaptor/scaffold; Autophagy; Membrane protein, peripheral Q14457 8678 17q21.31 human S93-p 5473540 ARMMSTEsANSFTLI molecular association, regulation; phosphorylation carcinogenesis, inhibited; autophagy, induced; apoptosis, induced; signaling pathway regulation DNAJB12(INDUCES); Bcl-2(DISRUPTS); SLC7A11(INDUCES) 23878393; 24685158; 26834238; 30057310; 31220095; 31696776; 32187724; 34820368; 36192481; 36410674 14 2 1 +Marcksl1 MLP Cell cycle regulation P28667 17357 4 D2.2|4 63.26 cM mouse T183-p 454301 PQAAEPStPSGPESG MARCKS protein conformation cytoskeletal reorganization; cell motility, inhibited 22751924 1 16 57 Increases actin stability and regulation of dendritic filopodium generation in neurons +AR AR DNA-binding; Nuclear receptor; Transcription factor P10275 367 Xq12 human S96-p 448416 QQQGEDGsPQAHRRG Androgen_recep activity, induced; protein stabilization; intracellular localization; protein conformation carcinogenesis, induced; cell growth, induced; transcription, induced; transcription, altered 15684382; 28003546; 34435708 9 11 0 inhibits ubiquitination +CSF1R CSFR EC 2.7.10.1; KINASE; Kinase, protein; Membrane protein, integral; Oncoprotein; Protein kinase, TK; Protein kinase, tyrosine (receptor) P07333 1436 5q32 human Y809-p 448365 DIMNDSNyIVKGNAR PK_Tyr_Ser-Thr activity, induced; phosphorylation cell cycle regulation; transcription, altered; cell growth, altered 15217985; 15297464; 7526094; 8761310 21 2 12 Substitution of T38A enhances Ets-1 rescue of CSFR defective receptor (Y809F). +RARG RARG DNA-binding; Nuclear receptor P13631 5916 12q13.13 human S390-p 1869601000 ITDLRGIsTKGAERA Hormone_recep activity, induced 31740618 1 0 0 +STMN1 STMN1 Cytoskeletal P16949 3925 1p36.11 human S63-p 448557 AAEERRKsHEAEVLK Stathmin protein degradation; molecular association, regulation; intracellular localization; activity, inhibited; phosphorylation cell cycle regulation; apoptosis, altered; carcinogenesis, inhibited; cell growth, inhibited; apoptosis, induced; cell motility, induced; cell motility, inhibited; signaling pathway regulation; autophagy, induced; cell growth, induced; cytoskeletal reorganization TUBA1A(DISRUPTS); TUBA4A(DISRUPTS); SQSTM1(INDUCES); TUBB(DISRUPTS) 10913145; 11015208; 11415983; 16554300; 17001604; 19359244; 20110360; 25198505; 30628717; 31546234; 33839152; 7775478; 9271428 26 56 32 +NEDD1 NEDD1 Cell cycle regulation Q8NHV4 121441 12q23.1 human S411-p 3207015 SSLGDMFsPIRDDAV molecular association, regulation; intracellular localization cytoskeletal reorganization HAUS8(INDUCES) 21690413; 22595525 3 19 0 Microtubule amplification pathway regulation +LIFR LIFR Membrane protein, integral; Receptor, cytokine P42702 3977 5p13.1 human K886-ac 62856001 CKALQFQkSVCEGSS protein conformation 28122243 1 1 0 ESC pluripotency in vivo +TBC1D3 TBC1D3 GAP; GAP, Rab; Oncoprotein Q8IZP1 729873 17q12 human K166-ub 64210902 FRDRYGTkQRELLHI RabGAP-TBC protein degradation; ubiquitination 28422741 1 0 0 +Cttn Cortactin Actin-binding; Cytoskeletal; Motility/polarity/chemotaxis Q60598 13043 7|7 F5 mouse T24-p 471533 GGADDWEtDPDFVND molecular association, regulation carcinogenesis, induced ARPC2(DISRUPTS) 30610108 1 5 6 increased invadopodia activity +Shc1 SHC1 iso2 Adaptor/scaffold; Apoptosis; Mitochondrial; Motility/polarity/chemotaxis P98083-2 20416 3 F1|3 39.11 cM mouse Y239-p 448509 EEPPDHQyYNDFPGK molecular association, regulation; phosphorylation cell motility, induced; cell motility, altered GRB2(INDUCES) 18273058; 23277357 32 22 947 angiogenesis; required for ErbB2- and TGFB mediated tumor metastasis to the lungs.; metastatic spread of tumors; required for migration and invasion of ERB2-expressing cells +FANCA FANCA DNA repair, damage O15360 2175 16q24.3 human K921-sm 40439802 RTFREVLkEEDVHLT protein degradation 25751062 1 0 0 +Esr2 ER-beta DNA-binding; Nuclear receptor O08537 13983 12 C3|12 33.52 cM mouse S87-p 447915 WPTSGHLsPLATHCQ ERbeta_N protein degradation; molecular association, regulation; ubiquitination; intracellular localization transcription, inhibited UBE3A(INDUCES); SRC-1(INDUCES) 10230404; 17962381 3 0 0 +ELF4 ELF4 DNA-binding; Oncoprotein; Transcription factor Q99607 2000 Xq26.1 human S648-p 463814 SPTPAPFsPFNPTSL protein degradation 16581786; 25081543 2 6 1 +PGR PR iso2 DNA-binding; Nuclear receptor; Transcription factor P06401-2 5241 11q22.1 human S390-p 11273301 PDSEASQsPQYSFES Prog_receptor protein degradation; ubiquitination carcinogenesis, altered; cell growth, inhibited; apoptosis, induced 23880761 2 1 0 +PLK1 PLK1 EC 2.7.11.21; KINASE; Kinase, protein; Protein kinase, Other; Protein kinase, Ser/Thr (non-receptor) P53350 5347 16p12.2 human S49-p 2715404 EVLVDPRsRRRYVRG enzymatic activity, induced cell cycle regulation 18427546 1 0 0 +Itpr1 IP3R1 Channel, calcium; Channel, ligand-gated; Membrane protein, integral; Membrane protein, multi-pass P29994 25262 4q41 rat S1589-p 450681 RNAARRDsVLAASRD activity, induced; receptor inactivation, altered 12167631; 15308649 10 51 3 Mutation of site to Glu enhanced, while mutation to Ala inhibited, calcium release through IP3R1.; increases the open probability of the IP3R receptor Ca(2+) channel +UIMC1 RAP80 Nuclear receptor co-regulator; Transcription, coactivator/corepressor Q96RL1 51720 5q35.2 human S44-p 470700 EDAFIVIsDSDGEEP molecular association, regulation SUMO2(INDUCES) 26719330 1 29 3 +Sh2d3c SHEP1 Adaptor/scaffold Q9QZS8 27387 2|2 B mouse Y787-p 452180 VAHHGGLyHTNAEVK molecular association, regulation cytoskeletal reorganization P130Cas(DISRUPTS) 15272013 1 1 1 Y787 phosphorylation inhibits cell migration and membrane ruffling +JAK2 JAK2 EC 2.7.10.2; KINASE; Kinase, protein; Oncoprotein; Protein kinase, TK; Protein kinase, tyrosine (non-receptor) O60674 3717 9p24.1 human K914-sm 31899107 HDNIVKYkGVCYSAG PK_Tyr_Ser-Thr molecular association, regulation; intracellular localization GH receptor(DISRUPTS) 23581279 1 0 0 translocation into the nucleus +H3c1 H3 DNA-binding P68433 360198 13|13 A3.1 mouse K122-ac 3652700 KRVTIMPkDIQLARR Histone transcription, induced 28077651 4 7 3 +Kcnb1 Kv2.1 Channel, cation; Channel, ligand-gated; Channel, potassium; Membrane protein, integral; Membrane protein, multi-pass P15387 25736 3q42 rat S799-p 473567 EKNHFESsPLPTSPK activity, induced; intracellular localization apoptosis, induced 23223293 5 3 0 +MAP9 MAP9 Cell cycle regulation Q49MG5 79884 4q32.1 human S625-p 999603 RKQKKRHsFLESEAL cytoskeletal reorganization 17925329 2 3 2 correct spindle formation during mitosis +PPDPF PPDPF Unknown function Q9H3Y8 79144 20q13.33 human Y17-p 1883583900 LVATHDYyRRRLGST protein stabilization; molecular association, regulation carcinogenesis, induced; cell growth, induced CK1A(INDUCES) 37477088 1 0 0 +H3c1 H3 DNA-binding P68433 360198 13|13 A3.1 mouse K9-m3 1458613 RTKQTARkSTGGKAP Histone molecular association, regulation; methylation; intracellular localization; enzymatic activity, induced cell differentiation, inhibited; cell cycle regulation; carcinogenesis, induced; endocytosis, altered; transcription, induced; transcription, altered; chromatin organization, altered; cell adhesion, altered; transcription, inhibited CBX4(DISRUPTS); HP1 alpha(INDUCES); CBX7(DISRUPTS); CBX3(INDUCES); CBX8(DISRUPTS); CBX1(INDUCES) DNA(INDUCES) 16222246; 17823087; 17967893; 18039862; 18728284; 20062804; 20543957; 20698834; 20935159; 21245376; 23293284; 24430871; 26051938; 26304540; 28666125; 33195484; 33971063 137 24 1 K885A mutant of SETDB1 inhibits enzyme activity but not its localization to target genes, mutant represses some adipogenic genes and inhibits adipocyte differentiation as does WT, but others arenot repressed and don't may not require its enzymatic activity and other H3K9 methyltransferases may be able to compensate. ; axon guidance +NR4A1 Nur77 Apoptosis; DNA-binding; Nuclear receptor P22736 3164 12q13.13 human T61-p 41583607 STFMDGYtGEFDTFL cell motility, induced; cell growth, induced; cytoskeletal reorganization 26155943 1 0 0 required for increase in cell growth, cell motility, monolayer permeability, and formation of actin stress fibers. +KCNK12 KCNK12 Membrane protein, integral; Membrane protein, multi-pass Q9HB15 56660 2p16.3 human S13-p 29668008 PRPPPRRsRRRLPRP activity, induced; intracellular localization 24163367 1 0 0 Channel current is increased in S13D mutant. Phosphorylation affects retrieval/retention signal, and allows KCNK12 to exit the ER and reach the plasma membrane. +NEDD1 NEDD1 Cell cycle regulation Q8NHV4 121441 12q23.1 human T560-p 25533013 PKIASSVtAGVASSL cytoskeletal reorganization 22595525 1 1 0 Negative effect on NEDD1 function +SMC1A Smc1 DNA replication; RNA splicing Q14683 8243 Xp11.22 human S957-p 448697 ISQEEGSsQGEDSVS SMC_N molecular association, regulation; intracellular localization cell cycle regulation; cytoskeletal reorganization RAE1(INDUCES) 11877376; 11877377; 18832153; 21757780 19 20 68 +SATB2 SATB2 DNA-binding Q9UPW6 23314 2q33.1 human K350-sm 2894438 PPIPRAVkPEPTNSS molecular association, regulation; intracellular localization transcription, inhibited DNA(DISRUPTS) 14701874 1 1 0 +NCOA3 SRC-3 ACETYLTRANSFERASE; Acetyltransferase; EC 2.3.1.48; Motility/polarity/chemotaxis; Nuclear receptor co-regulator; Transcription, coactivator/corepressor Q9Y6Q9 8202 20q13.12 human S860-p 454106 NRAVSLDsPVSVGSS protein degradation; molecular association, regulation; ubiquitination carcinogenesis, induced; cell growth, induced; cell growth, inhibited; transcription, induced ER-alpha(DISRUPTS); CUL3(INDUCES) DNA(DISRUPTS) 15383283; 16760465; 22147914; 33542078 7 16 0 +Gch1 GCH1 Cofactor and Vitamin Metabolism - folate biosynthesis; EC 3.5.4.16; Hydrolase P22288 29244 15p14 rat T85-p 10428812 QRQGLLKtPWRAATA GTP_cyclohydroI enzymatic activity, induced 19762783 1 0 0 +NF2 Merlin Cytoskeletal; Motility/polarity/chemotaxis; Tumor suppressor P35240 4771 22q12.2 human K439-ub 964526678 EAEVLALkMAEESER ERM_helical molecular association, regulation; intracellular localization LATS1(DISRUPTS) 30918126 1 2 0 K63 kinked +VRK3 VRK3 EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, CK1; Protein kinase, Ser/Thr (non-receptor) Q8IV63 51231 19q13.33 human S108-p 4762306 RPPTPKSsPQKTRKS molecular association, regulation; intracellular localization; enzymatic activity, induced apoptosis, inhibited ERK2(INDUCES) 27346674 1 11 2 recruitment of phospho-ERK to VHR, VHR phosphatase activity increased, increased Bak and Bax expression, +GPR35 GPR35 GPCR, family 1; Membrane protein, integral; Membrane protein, multi-pass; Receptor, GPCR Q9HC97 2859 2q37.3 human S303-p 1876282806 KAHKSQDsLCVTLA_ receptor internalization, induced; molecular association, regulation; intracellular localization ARR3(INDUCES) 35101446 1 1 0 +SLC6A2 SLC6A2 Membrane protein, integral; Membrane protein, multi-pass; Transporter; Transporter, SLC family P23975 6530 16q12.2 human S259-p 465614 LWKGVKTsGKVVWIT SNF receptor internalization, induced; intracellular localization; activity, inhibited 16740633; 23979140 2 0 0 Raft-rich membrane domains serve as transit cargos for transporter internalization.; effect observed in T258, S259 double mutant +Sv2a SV2A Membrane protein, integral; Membrane protein, multi-pass; Vesicle Q9JIS5 64051 3|3 F2.1 mouse S81-p 4779758 EEEGGASsDATEGHD molecular association, regulation SYT1(INDUCES) 25673844 1 9 11 SV2A retrieval during SV endocytosis, Thr84 of SV2A is critical in promoting the interaction with synaptotagmin-1 +SLC12A1 NKCC2 Membrane protein, integral; Membrane protein, multi-pass; Transporter; Transporter, SLC family P55015 100328575 rabbit T104-p 458228 LQTFGHNtMDAVPKI AA_permease_N activity, induced 16077079 14 2 0 +Plekhg5 PLEKHG5 Q66T02 269608 4|4 E2 mouse S938-p 7104662 PRLLKSKsEASLLQL molecular association, regulation; intracellular localization; enzymatic activity, inhibited cytoskeletal reorganization; cell adhesion, inhibited 14-3-3 beta(INDUCES); RHOA(DISRUPTS); 14-3-3 epsilon(INDUCES); 14-3-3 gamma(INDUCES) 23335514 1 10 0 inhibits targeting to cell border +HIF1A HIF1A Autophagy; DNA-binding; Transcription factor Q16665 3091 14q23.2 human S687-p 31876388 TEKSHPRsPNVLSVA protein stabilization 27027353 1 5 0 +Smad4 SMAD4 DNA-binding; Nuclear receptor co-regulator; Transcription, coactivator/corepressor P97471 17128 18 E2|18 49.51 cM mouse K113-sm 2793926 KNELKHVkYCQYAFD MH1 neural plasticity; transcription, induced 29183317 5 1 0 induces spatial learning and memory +MAP3K11 MLK3 EC 2.7.11.25; KINASE; Kinase, protein; Protein kinase, Ser/Thr (non-receptor); Protein kinase, TKL Q16584 4296 11q13.1 human T277-p 448263 LAREWHKtTQMSAAG PK_Tyr_Ser-Thr molecular association, regulation; enzymatic activity, induced cell differentiation, induced GEFT(INDUCES) 11053428; 18851832; 21965325 8 0 0 +Kcnb1 Kv2.1 Channel, cation; Channel, ligand-gated; Channel, potassium; Membrane protein, integral; Membrane protein, multi-pass P15387 25736 3q42 rat S484-p 473560 KVQDNHLsPNKWKWT Kv2channel activity, inhibited 16917065 1 6 5 +ITGAE ITGAE Membrane protein, integral; Motility/polarity/chemotaxis P38570 3682 17p13.2 human S1163-p 334535807 YQQLNLEsIRKAQLK intracellular localization cell adhesion, induced 29021139 1 0 0 recruit Pxn at the contact area, outside-in signaling ; clustering and lysosome relocalization +Lipe HSL EC 3.1.1.79; Lipase P54310 16890 7 A3|7 13.78 cM mouse S358-p 1872513511 GGFVAQTsKSHEPYL Abhydrolase_3 enzymatic activity, induced autophagy, inhibited 33657384; 34695513 6 1 0 +ITIH2 ITIH2 Inhibitor; Secreted; Secreted, signal peptide P19823 3698 10p14 human S60-p 454327 QRSLPGEsEEMMEEV carcinogenesis, induced 36114575 0 15 0 +ERBB3 HER3 EC 2.7.10.1; KINASE; Kinase, protein; Membrane protein, integral; Oncoprotein; Protein kinase, TK; Protein kinase, tyrosine (receptor) P21860 2065 12q13.2 human Y1289-p 449858 CPASEQGyEEMRAFQ activity, induced; molecular association, regulation; enzymatic activity, induced carcinogenesis, induced; cell growth, induced; cell motility, induced; apoptosis, inhibited; signaling pathway regulation; cell growth, altered PIK3R2(INDUCES); PIK3R1(INDUCES) 16729043; 20227043; 21725367; 21918175; 31978707; 32029900; 34320350; 34385295 30 10 125 +DNM1L DRP1 Apoptosis; EC 3.6.5.5; Endoplasmic reticulum; Hydrolase; Microtubule-binding; Mitochondrial; Motor O00429 10059 12p11.21 human T595-p 28716001 NWRGMLKtSKAEELL activity, induced autophagy, induced 23813973 1 1 0 induce mitochondrial fragmentation +Srsf1 SF2 RNA splicing; RNA-binding; Spliceosome NP_001103022 689890 10q26 rat S234-p 468704 SPRRSRGsPRYSPRH intracellular localization 18658135 2 41 16 inhibits tau exon 10 inclusion, and increases 3R-tau production +Cttn Cortactin Actin-binding; Cytoskeletal; Motility/polarity/chemotaxis NP_001385572 60465 1q41-q42 rat T145-p 41425400 GFEYQGKtEKHASQK HS1_rep molecular association, regulation cell motility, inhibited; cytoskeletal reorganization ACTB(DISRUPTS) 26033110; 30570111 2 1 0 decrease actin bundling, altered higher order structure of dynamin1-cort complex, deformed lamelipodia and short filopodia; phospho-mimetic mutant shows atypical growth cone filopodia +CGAS cGAS EC 2.7.7.86 Q8N884 115004 6q13 human R124-m2 1881215700 RAGSCRQrGARCSTK molecular association, regulation DNA(DISRUPTS) 33762328 1 1 0 +Mdm4 MDM4 EC 6.3.2.-; Ligase; UBIQUITIN LIGASE; Ubiquitin conjugating system; Ubiquitin ligase O35618 17248 1 E4|1 57.75 cM mouse S341-p 470031 SKLTHSLsTSNITAI molecular association, regulation cell cycle regulation; signaling pathway regulation 14-3-3 gamma(INDUCES) 22556425; 24190973 12 7 3 +KRT8 K8 Cytoskeletal P05787 3856 12q13.13 human Y267-p 457880 IAEVKAQyEDIANRS Filament cytoskeletal reorganization 24003221 1 10 451 +BCL2L11 BIM Apoptosis O43521 10018 2q13 human K3-ub 25087001 _____MAkQPSDVSS protein degradation apoptosis, inhibited 14657036 3 0 0 +IGF1R IGF1R EC 2.7.10.1; KINASE; Kinase, protein; Membrane protein, integral; Protein kinase, TK; Protein kinase, tyrosine (receptor) P08069 3480 15q26.3 human Y1161-p 448386 FGMTRDIyETDYYRK PK_Tyr_Ser-Thr molecular association, regulation; receptor internalization, altered; protein conformation; phosphorylation; enzymatic activity, induced carcinogenesis, induced; autophagy, induced; cell growth, inhibited; apoptosis, induced; cell motility, induced; apoptosis, inhibited; signaling pathway regulation Src(INDUCES) 11591350; 16037379; 16793764; 21685939; 30833419; 34921013; 36149602; 7588225 22 31 455 +ERG ERG DNA-binding; Oncoprotein; Transcription factor P11308 2078 21q22.2 human S39-p 50259800 EMTASSSsDYGQTSK protein degradation; molecular association, regulation cell motility, inhibited SPOP(INDUCES) 26344095 1 1 0 +Myo3a MYO3A Actin-binding; EC 2.7.11.1; KINASE; Kinase, protein; Motor; Protein kinase, STE; Protein kinase, Ser/Thr (non-receptor) Q8K3H5 667663 2|2 A3 mouse S332-p 36841903 KKGNLNRsLISSLKD enzymatic activity, induced 21895655 1 1 0 +HDAC4 HDAC4 DEACETYLASE; Deacetylase; EC 3.5.1.98; Hydrolase; Nuclear receptor co-regulator; SUMO LIGASE P56524 9759 2q37.3 human S266-p 4737976 KVAERRSsPLLRRKD activity, induced; intracellular localization transcription, inhibited 23652597; 29472387; 30661366 4 20 1 transcription of MEF2 target genes RhoB and Klf2 +NOTCH1 Notch 1 Membrane protein, integral; Motility/polarity/chemotaxis; Oncoprotein; Receptor, misc.; Transcription factor P46531 4851 9q34.3 human S2521-p 467287 PESPDQWsSSSPHSN protein degradation; receptor inactivation, altered 16880534 1 0 0 Alanine mutation of 4 serines (S2522/S2523/S2524/S2525) causes increased protein stability. +Ctnnb1 CTNNB1 Actin-binding; Cell adhesion; Motility/polarity/chemotaxis; Nuclear receptor co-regulator; Oncoprotein; Transcription factor Q02248 12387 9 F4|9 72.19 cM mouse S552-p 472273 QDTQRRTsMGGTQQQ intracellular localization cell differentiation, inhibited; carcinogenesis, induced; transcription, induced; signaling pathway regulation; transcription, altered 17237784; 20230753; 32102932; 34580275; 34642308 44 64 9 regulates the Wnt signaling pathway +BAIAP2 IRSp53 Actin-binding; Motility/polarity/chemotaxis Q9UQB8 10458 17q25.3 human T340-p 2049593 LSDSYSNtLPVRKSV molecular association, regulation cytoskeletal reorganization 14-3-3 zeta(INDUCES) 19933840 1 30 24 +USP25 USP25 DEUBIQUITINASE; EC 3.4.19.12; Protease; Ubiquitin conjugating system; Ubiquitin-specific protease Q9UHP3 29761 21q21.1 human S745-p 40407602 PEYLEQPsRSDFSKH ubiquitination; enzymatic activity, inhibited 25755282 1 0 0 in vitro deubiquitination assays +CD274 PD-L1 Membrane protein, integral Q9NZQ7 29126 9p24.1 human T290-p 56667601 SDTHLEEt_______ protein stabilization; molecular association, regulation carcinogenesis, induced SPOP(DISRUPTS) 35385574 2 2 0 inhibits ubiquitination +IQCB1 IQCB1 Cell development/differentiation Q15051 9657 3q13.33|3q21.1 human K33-ub 95155303 PVILLKLkEIINITP intracellular localization cell cycle regulation; cytoskeletal reorganization 28498859 1 3 0 regulation of cilia formation +ARHGEF7 ARHGEF7 iso1 GEF; GEF, Rac/Rho; Motility/polarity/chemotaxis Q14155-1 8874 13q34 human S525-p 455681 EEFASRKsTAALEED RhoGEF67_u2 activity, induced cytoskeletal reorganization 14557270 3 19 2 S525/T526 phosphorylation regulates Rac1 activation and growth cone extension/retraction. +Eef2k EEF2K EC 2.7.11.20; KINASE; Kinase, protein; Protein kinase, Ser/Thr (non-receptor); Protein kinase, atypical; Translation P70531 25435 1q36 rat S365-p 447827 SPRIRTLsGSRPPLL phosphorylation 33191388 16 11 20 inhibits phosphorylation of EEf2 +Cd3e CD3E Membrane protein, integral; Receptor, misc. P22646 12501 9 A5.2|9 24.84 cM mouse Y181-p 448917 RKGQRDLySGLNQRA ITAM molecular association, regulation PIK3R1(INDUCES) 9312149 4 15 398 +CRYAA CRYA1 Chaperone; Heat shock protein P02489 1409 21q22.3 human T148-p 452108 FCGPKIQtGLDATHA HSP20 activity, induced; molecular association, regulation; intracellular localization; phosphorylation apoptosis, inhibited; transcription, inhibited CRYA1(DISRUPTS) 29467334; 34071438; 35168949; 35669493 5 5 0 +PPARA PPAR-alpha DNA-binding; Nuclear receptor; UBIQUITIN LIGASE Q07869 5465 22q13.31 human S179-p 457549 RFGRMPRsEKAKLKA transcription, altered 15131257 2 0 0 +NUP50 NUP50 Nuclear import; Nucleoporin Q9UKX7 10762 22q13.31 human S315-p 4957816 TQSKPVSsPFPTKPL molecular association, regulation KPNB1(DISRUPTS) 19767751 1 2 1 +ARID4A RbBP1 Adaptor/scaffold P29374 5926 14q23.1 human S1007-p 17743401 QHNFSVAsPLTLSQD molecular association, regulation Rb(DISRUPTS) 21148318 1 1 0 +JAK2 JAK2 EC 2.7.10.2; KINASE; Kinase, protein; Oncoprotein; Protein kinase, TK; Protein kinase, tyrosine (non-receptor) O60674 3717 9p24.1 human Y201-p 470070 DQTPLAIyNSISYKT FERM_F2 molecular association, regulation; phosphorylation carcinogenesis, induced; cell growth, induced; apoptosis, inhibited; signaling pathway regulation STAT5A(INDUCES); SHP-2(INDUCES) 22837531 3 1 0 induces phosphorylation of JAK2, STAT5 and SHP2 +MAP2K2 MEK2 EC 2.7.12.2; KINASE; Kinase, protein; Protein kinase, STE; Protein kinase, dual-specificity (non-receptor) P36507 5605 19p13.3 human T13-gl 1871246004 KPVLPALtINPTIAE protein stabilization; phosphorylation cell cycle regulation; carcinogenesis, induced; cell motility, induced; cell growth, induced; signaling pathway regulation 33226073 1 1 0 promotes phosphorylation at MEK2-T394, activates MEK2/ERK1/2 signaling cascade +Tp53 p53 Activator; DNA-binding; Motility/polarity/chemotaxis; Nuclear receptor co-regulator; Transcription factor; Tumor suppressor P02340 22059 11 B3|11 42.83 cM mouse K383-ac 486382 RHKKTMVkKVGPDSD activity, induced apoptosis, induced; transcription, induced 25758227; 33323382 12 2 1 P53K Q/- mice died prematurely due to anemia, loss of hematopoiesis stem cells, Loss of stem cells in the testis, activation in p53 KQ/- mice without robust p53 stabilization,p53-KQ/- mutant leads to effective suppression of tumor development in a pancreatic ductal adenocarcinoma mouse model, mutant proteins extended the life-span of a PDAC mouse model +Cebpa C/EBP-alpha DNA-binding; Transcription factor P05554 24252 1q21 rat K159-sm 2793923 ALRPLVIkQEPREED molecular association, regulation transcription, inhibited HDAC3(INDUCES) 23639777 5 1 0 +PDE4C PDE4C iso2 EC 3.1.4.53; Nucleotide Metabolism - purine; Phosphodiesterase Q08493-2 5143 19p13.11 human S535-p 471381 YQSKIPRsPSDLTNP enzymatic activity, inhibited 11030732 1 4 0 +AP4E1 AP4E1 Adaptor/scaffold Q9UPM8 23431 15q21.2 human S847-p 15407703 DKELKKFsLTSELLD receptor recycling, inhibited 21810154 1 0 0 +RACK1 RACK1 Adaptor/scaffold; G protein; G protein, heterotrimeric; G protein, heterotrimeric beta; Motility/polarity/chemotaxis; Nuclear receptor co-regulator P63244 10399 5q35.3 human K257-ub 10840127 AATGPSIkIWDLEGK WD40 protein degradation carcinogenesis, induced 33323973 1 7 54 +IRS1 IRS1 Adaptor/scaffold; Motility/polarity/chemotaxis P35568 3667 2q36.3 human S527-p 447561 RFRKRTHsAGTSPTI intracellular localization signaling pathway regulation 16914728; 34253290; 35810470 7 23 0 disassociation of IRS2 from plasma membrane to cytosol; via cell fractionation experiments; regulates insulin signaling; limits PM-associated PI3K and PIP3 synthesis +RAD9A RAD9A Apoptosis; Cell cycle regulation; DNA replication; Deoxyribonuclease; EC 3.1.11.2 Q99638 5883 11q13.2 human T355-p 449818 EPSTVPGtPPPKKFR cell cycle regulation 12734188; 20305300; 24376897 5 8 11 phosphorylation increases as cells enter mitosis, important for exiting the damage-induced G2/M checkpoint +PPP1R3F PPP1R3F Membrane protein, integral; Protein phosphatase, regulatory subunit Q6ZSY5 89801 Xp11.23 human S400-p 22650302 EEGDVPRsSPPVAFT signaling pathway regulation 21668450 0 1 0 regulation of glycogen synthesis via R3F-PP1 signaling in astrocytoma cells +MAPK14 P38A EC 2.7.11.24; KINASE; Kinase, protein; Protein kinase, CMGC; Protein kinase, Ser/Thr (non-receptor) Q16539 1432 6p21.31 human T123-p 471074 IVKCQKLtDDHVQFL Pkinase molecular association, regulation; enzymatic activity, inhibited; phosphorylation cell differentiation, altered MAPKAPK2(DISRUPTS); MKK6(DISRUPTS) 17055984 1 0 0 Phosphorylation leads to less interaction with activator (MKK6) and substrates (MAPKAPK2). +Trpv4 TRPV4 Channel, cation; Membrane protein, integral; Membrane protein, multi-pass Q9EPK8 63873 5|5 F mouse Y110-p 4777176 PMDSLFDyGTYRHHP activity, induced; intracellular localization 19033444 3 4 0 +NASP NASP iso2 Cell cycle regulation P49321-2 4678 1p34.1 human S158-p 476187 TEEMPNDsVLENKSL molecular association, regulation TRAF6(DISRUPTS) 29733298 1 17 0 mounting of an effective immune response during sepsis +NPM1 NPM1 Nucleolus; Oncoprotein; RNA-binding; Translation P06748 4869 5q35.1 human S88-p 4169620 MSVQPTVsLGGFEIT Nucleoplasmin protein stabilization; molecular association, regulation ARF1(INDUCES) 23851489 2 12 0 increase ARF protein stabilization +CASP9 CASP9 Apoptosis; EC 3.4.22.62; Protease P55211 842 1p36.21 human S144-p 458346 GDVGALEsLRGNADL activity, inhibited apoptosis, altered 16287866 1 0 0 +ETV4 ETV4 DNA-binding P43268 2118 17q21.31 human K260-sm 3144815 PGAGVVIkQEQTDFA ETS_PEA3_N transcription, inhibited 17585876 4 1 0 +Sntb2 SNTB2 Adaptor/scaffold; Dystrophin complex; Extracellular matrix Q61235 20650 8 D3|8 53.38 cM mouse S90-p 471148 PAGEASAsPPVRRVR molecular association, regulation; intracellular localization exocytosis, altered PTPRN(INDUCES) 20886068 1 82 5 +NRP1 NRP1 Membrane protein, integral; Receptor, misc. O14786 8829 10p11.22 human Y297-p 21656101 QITASSQySTNWSAE F5_F8_type_C molecular association, regulation; phosphorylation cell motility, induced NRP1(INDUCES) 21653826 1 0 0 binding to NRP1 is required for FAK signaling +Cryab CRYAB Chaperone; Heat shock protein P23928 25420 8q23 rat S19-p 447728 RPFFPFHsPSRLFDQ Crystallin protein degradation; intracellular localization; phosphorylation apoptosis, altered; signaling pathway regulation 12574148; 22870022; 24159092; 27851782; 33220080 26 16 2 localization of phosphorylated alpha-BCs in the diabetic retina +EPAS1 HIF2A DNA-binding; Transcription factor Q99814 2034 2p21 human S790-p 1883618704 PQPPSAIsPGENSKS protein stabilization; molecular association, regulation carcinogenesis, induced; cell motility, induced PIN1(INDUCES) 37473874 1 1 0 +Erbb3 HER3 EC 2.7.10.1; KINASE; Kinase, protein; Membrane protein, integral; Oncoprotein; Protein kinase, TK; Protein kinase, tyrosine (receptor) Q62799 29496 7q11 rat Y1257-p 449860 GTTPDEDyEYMNRRR molecular association, regulation; phosphorylation PIK3CB(INDUCES); PIK3R1(INDUCES) 11546794 3 0 16 induces phosphorylation of Akt1. +Xbp1 XBP1 iso2 DNA-binding; Transcription factor O35426-2 22433 mouse K276-sm 13875701 SQTNVVVkIEEAPLS intracellular localization transcription, inhibited 20408817; 34421344 2 0 0 +Rela NFkB-p65 DNA-binding; Nuclear receptor co-regulator; Transcription factor Q7TQN4 309165 1q43 rat S311-p 449966 RTYETFKsIMKKSPF apoptosis, inhibited 21550382 17 2 1 induces cell survival +IRF1 IRF1 Transcription factor; Tumor suppressor P10914 3659 5q31.1 human K117-ub 31914115 RMLPPLTkNQRKERK protein degradation; molecular association, regulation DNA(DISRUPTS) 23134341 1 2 0 +CTDSPL2 CTDSPL2 EC 3.1.3.-; Motility/polarity/chemotaxis; PHOSPHATASE; Phosphatase Q05D32 51496 15q15.3-q21.1 human S104-p 3205830 ISRVRRKsQVNGEAG cell cycle regulation; carcinogenesis, induced; cell motility, induced; cell growth, induced; transcription, inhibited 34813892 1 24 201 +ETFB ETFB Mitochondrial; Oxidoreductase P38117 2109 19q13.41 human K200-m2 3899873 ATLPNIMkAKKKKIE ETF enzymatic activity, inhibited 25416781 1 1 5 inhibitory effect on the transfer of electrons +Syngap1 SynGAP GAP; GAP, Ras F6SEU4 240057 17|17 A3.3 mouse S788-p 19014968 MDMARLPsPTKEKPP DUF3498 protein conformation; activity, inhibited translation, induced; signaling pathway regulation 25533468; 36315645 2 3 20 regulates mTORC1 signalling; S788D and T790D mutations inhibit Rap2 GAP and HRas GAP activities of SynGAP +GARS1 GARS Aminoacyl-tRNA synthetase; EC 6.1.1.14; Ligase; Mitochondrial; Translation; Translation regulation P41250 2617 7p14.3 human T544-p 1352793600 KGEFTIEtEGKTFQL tRNA-synt_2b molecular association, regulation; intracellular localization NFkB-p100(INDUCES) 30471104 1 0 0 +PPP1R14C KEPI Inhibitor; Protein phosphatase, regulatory subunit Q8TAE6 81706 6q25.1 human T73-p 10296602 RHQQGKVtVKYDRKE PP1_inhibitor molecular association, regulation; phosphorylation cell cycle regulation; carcinogenesis, induced; cell motility, induced; cell growth, induced; cytoskeletal reorganization PPP1CA(INDUCES) 25531779; 35090098 3 4 1 +Pelp1 PELP1 Nuclear receptor co-regulator; Transcription, coactivator/corepressor Q9DBD5 75273 11|11 B3 mouse T751-p 453708 PVLAPSGtPPPSIPP protein degradation 26627258 1 32 0 E2 has a protective effect of restoring the PELP1 levels by blocking GSK3B activation. +NCAPD3 NCAPD3 Cell cycle regulation P42695 23310 11q25 human T1415-p 10790749 VTKRAIStPEKSISD molecular association, regulation; phosphorylation cell cycle regulation; chromatin organization, altered PLK1(INDUCES) 21498573; 30626720 3 4 4 +SHARPIN SHARPIN Apoptosis Q9H0F6 81858 8q24.3 human S165-p 3245774 PEADLPRsPGNLTER protein degradation; ubiquitination; intracellular localization transcription, induced 33392484 1 15 6 causes ubiquitination and protein degradation of IKB, and NF-kB translocation to the nucleus +Git1 GIT1 GAP; GAP, ARF; Motility/polarity/chemotaxis Q68FF6 216963 11|11 B5 mouse S419-p 482779 TRNNRARsMDSSDLS GIT_CC molecular association, regulation CAMK2A(INDUCES) 23352984 1 40 7 synapsin I density is decreased in S419A mutant; interaction is important for premature synapse formation. +Sod2 SOD2 EC 1.15.1.1; Mitochondrial; Oxidoreductase P09671 20656 17 A1|17 8.75 cM mouse K68-sc 33340970 NLNATEEkYHEALAK Sod_Fe_N enzymatic activity, inhibited 36654268 1 2 0 +CALD1 Caldesmon iso4 Actin-binding Q05682-4 800 7q33 human S534-p 448466 QSVDKVTsPTKV___ molecular association, regulation cell motility, induced; cytoskeletal reorganization leupaxin(INDUCES) 26079947 19 19 0 +EDNRA EDNRA GPCR, family 1; Membrane protein, integral; Membrane protein, multi-pass; Motility/polarity/chemotaxis; Receptor, GPCR P25101 1909 4q31.22-q31.23 human S425-p 2911707 DRSSHKDsMN_____ receptor desensitization, induced 24064210 1 2 0 Lack of S397, T403 and S404 influences desensitization to a greater extent compared than S391, S393, and T396 +L1CAM NCAM-L1 Cell adhesion; Membrane protein, integral P32004 3897 Xq28 human T1172-p 4702537 ARPMKDEtFGEYRSL Bravo_FIGEY protein degradation; protein conformation cell motility, altered 20335502 2 6 7 +IFNLR1 IL28RA Membrane protein, integral Q8IU57 163702 1p36.11 human K320-ub 1883375200 TQQTRWKkDLAEDEE protein degradation 36379255 1 0 0 +Mos MOS EC 2.7.11.1; KINASE; Kinase, protein; Oncoprotein; Protein kinase, Other; Protein kinase, Ser/Thr (non-receptor) P00536 17451 4 A1|4 2.16 cM mouse S25-p 448659 SVDSRSCsIPLVAPR enzymatic activity, inhibited 9632642 3 1 0 in vitro +ATIC ATIC Cofactor and Vitamin Metabolism - one carbon pool by folate; EC 2.1.2.3; EC 3.5.4.10; Hydrolase; METHYLTRANSFERASE; Methyltransferase; Mitochondrial; Nucleotide Metabolism - purine P31939 471 2q35 human Y104-p 456299 RVVACNLyPFVKTVA MGS enzymatic activity, induced 18845790 1 8 105 +NDC80 HEC1 Cell cycle regulation O14777 10403 18p11.32 human S5-p 474510 ___MKRSsVSSGGAG cell cycle regulation 17129782; 36897279 2 1 0 +PAK2 PAK2 EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, STE; Protein kinase, Ser/Thr (non-receptor) Q29502 100009535 rabbit T402-p 448300 PEQSKRStMVGTPYW Pkinase enzymatic activity, induced 18984590 15 2 11 +TRIM28 TIF1B EC 6.3.2.-; KINASE; Kinase, protein; Ligase; Nuclear receptor co-regulator; Protein kinase, atypical; SUMO LIGASE; SUMO ligase; Transcription, coactivator/corepressor; UBIQUITIN LIGASE; Ubiquitin conjugating system; Ubiquitin ligase Q13263 10155 19q13.43 human K774-ub 12315244 RMFKQFNkLTEDKAD protein degradation 26676607 0 6 13 +FOS Fos DNA-binding; Motility/polarity/chemotaxis; Oncoprotein; Transcription factor P01100 2353 14q24.3 human T331-p 448484 CTPVVTCtPSCTAYT carcinogenesis, induced; transcription, induced 23667255 4 0 0 nuclear import of HBXIP +LIMK2 LIMK2 EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, Ser/Thr (non-receptor); Protein kinase, TKL P53671 3985 22q12.2 human T505-p 448683 NDRKKRYtVVGNPYW PK_Tyr_Ser-Thr activity, induced; protein stabilization; molecular association, regulation; intracellular localization; enzymatic activity, induced cell cycle regulation; cell adhesion, induced; cytoskeletal reorganization ROCK2(INDUCES) 11171090; 19099536; 21423216; 22492986; 23934191 17 1 1 +PYCARD PYCARD Adaptor/scaffold; Tumor suppressor Q9ULZ3 29108 16p11.2 human Y146-p 465096 KVLTDEQyQAVRAEP CARD molecular association, regulation PYCARD(INDUCES) 33568399 4 2 4 mediated/regulates pyroptosis +Ahcyl1 AHCYL1 Amino Acid Metabolism - cysteine and methionine; EC 3.3.1.1; Hydrolase; Other Amino Acids Metabolism - selenoamino acid Q80SW1 229709 3 F2.3|3 46.83 cM mouse S74-p 467246 ISQSSTDsYSSAASY molecular association, regulation PIP5K1A(INDUCES); IP3R1(INDUCES) 16793548; 26509711 5 1 0 +Mdm2 MDM2 EC 6.3.2.-; EC 6.3.2.19; Inhibitor; Ligase; NEDDYLATION LIGASE; Neddylation Ligase; Nucleolus; Oncoprotein; UBIQUITIN LIGASE; Ubiquitin conjugating system; Ubiquitin ligase P23804 17246 10 D2|10 66.32 cM mouse T216-p 450150 SSSESTEtPSHQDLD molecular association, regulation 11359766 4 0 0 +MCRIP1 FAM195B C9JLW8 348262 17q25.3 human T30-p 9322247 PSSSEIFtPAHEENV FAM195 molecular association, regulation transcription, induced CTBP1(DISRUPTS) 25728771 2 5 14 freed CtBP binds to ZEB1, regulates epithelial-mesenchymal transition (EMT). +KHDRBS1 KHDRBS1 RNA-binding Q07666 10657 1p35.2 human T61-p 3194543 GARASPAtQPPPLLP molecular association, regulation DNA repair, induced; RNA splicing, induced PARP1(INDUCES) RNA(INDUCES) 36010841 1 6 0 +FBXW7 FBXW7 Motility/polarity/chemotaxis; Nucleolus; UBIQUITIN LIGASE; Ubiquitin conjugating system; Ubiquitin ligase Q969H0 55294 4q31.3 human S10-p 17337000 QELLSVGsKRRRTGG intracellular localization 20815813 1 1 0 +MIEN1 MIEN1 Apoptosis; Motility/polarity/chemotaxis Q9BRT3 84299 17q12 human Y39-p 48921821 PCGFEATyLELASAV Rdx carcinogenesis, induced; cell motility, induced 26272794 1 0 0 +MAP3K7 TAK1 EC 2.7.11.25; KINASE; Kinase, protein; Protein kinase, Ser/Thr (non-receptor); Protein kinase, TKL O43318 6885 6q15 human K158-ub 13310800 ALIHRDLkPPNLLLV PK_Tyr_Ser-Thr molecular association, regulation; enzymatic activity, induced transcription, induced; signaling pathway regulation IKKB(INDUCES); IKKG(INDUCES) 20038579; 22981905 3 0 0 regulation of IKKs and NF-kB activation during Dox-induction. +YAP1 YAP1 Oncoprotein; Transcription, coactivator/corepressor P46937 10413 11q22.1 human S163-p 3190657 TAQHLRQsSFEIPDD cell growth, induced; transcription, inhibited 28416665 2 11 14 sensitivity to gemcitabine +Hist1h2ail1 H3 DNA-binding Q6LED0 291159 17p11 rat K9-ac 463820 RTKQTARkSTGGKAP Histone molecular association, regulation transcription, induced DNA(INDUCES) 16081763; 17495236; 19476549; 26298192 230 26 341 +Map2 MAP2 iso3 Cytoskeletal; Motility/polarity/chemotaxis P15146-3 25595 9q32 rat T220-p 2999205 ISSARRTtRSEPIRR protein degradation; molecular association, regulation TUBA1A(DISRUPTS); TUBB(DISRUPTS) 12369833 2 1 0 +VIL1 Villin Actin-binding; Motility/polarity/chemotaxis P09327 7429 2q35 human Y60-p 454005 KTASSLSyDIHYWIG Gelsolin molecular association, regulation; intracellular localization cytoskeletal reorganization ACTB(INDUCES) 12269817; 15342783 3 0 0 +RBL2 Rb-like 2 Transcription, coactivator/corepressor; Tumor suppressor Q08999 5934 16q12.2 human T986-p 449737 QPSSAPPtPTRLTGA RB_B molecular association, regulation cell cycle regulation E2F4(DISRUPTS) 11157749 3 16 6 +Pparg PPAR-gamma DNA-binding; Nuclear receptor; Transcription factor P37238 19016 6 E3|6 53.41 cM mouse S112-p 448062 AIKVEPAsPPYYSEK sumoylation; molecular association, regulation; intracellular localization; activity, inhibited cell differentiation, inhibited; cell differentiation, altered; cell differentiation, induced; transcription, inhibited; cell growth, altered TAZ(INDUCES) 12777391; 14536066; 16534556; 18204460; 21994940; 26206105; 27341689; 31708444; 33539723; 33567272; 36840344 33 7 0 +Slc38a3 SLC38A3 Membrane protein, integral; Membrane protein, multi-pass; Transporter; Transporter, SLC family Q9JHZ9 252919 8q32 rat S52-p 19001700 KGFLQQSsSKEPHFT protein degradation; intracellular localization 21525297 1 0 0 protein internalization +Relb RELB Transcription factor Q04863 19698 7 A3|7 9.93 cM mouse S368-p 455656 RLTDGVCsEPLPFTY RHD_dimer molecular association, regulation transcription, altered NFkB-p105(INDUCES); NFkB-p100(INDUCES) 12874295 1 0 0 +ILF3 NFAT90 DNA-binding; Nucleolus; RNA-binding; Transcription factor Q12906 3609 19p13.2 human T188-p 17734001 EKVLAGEtLSVNDPP DZF intracellular localization 24920670 3 1 0 cytoplasmic retention, which increases its association with and assembly of large RNA granules +Tbc1d4 AS160 GAP; GAP, Rab Q8BYJ6 210789 14|14 E2.3 mouse S595-p 455920 RMRGRLGsMDSFERA molecular association, regulation; phosphorylation IRAP(DISRUPTS); 14-3-3 gamma(INDUCES) 19923418; 33872597 21 68 253 affects phosphorylation of other sites by AKT +ENO1 ENO1 Carbohydrate Metabolism - glycolysis and gluconeogenesis; EC 4.2.1.11; Lyase; Transcription, coactivator/corepressor P06733 2023 1p36.23 human S282-p 22777189 QLADLYKsFIKDYPV Enolase_C enzymatic activity, inhibited 27153534 1 4 11 +Mapkapk2 MAPKAPK2 EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, CAMK; Protein kinase, Ser/Thr (non-receptor) P49138 17164 1|1 E4 mouse T320-p 448273 QSTKVPQtPLHTSRV intracellular localization; enzymatic activity, induced transcription, induced 33504618; 7592979; 9628873 31 14 38 induces immunosuppression +Espl1 separase EC 3.4.22.49; Protease P60330 105988 15|15 F3 mouse S1120-p 4270957 PIQSSVNsSPVLKTK molecular association, regulation cytoskeletal reorganization 23857768 1 0 0 S1120 T1341 AA mutant -fewer cold-stable kinetochore-microtubule attachments and lacks tension +SPHK2 SPHK2 EC 2.7.1.91; Kinase, lipid; Lipid Metabolism - sphingolipid Q9NRA0 56848 19q13.33 human T614-p 477182 AFRLEPLtPRGVLTV YegS_C cell motility, altered 17311928 1 1 0 +PEA15 PEA-15 Apoptosis; Motility/polarity/chemotaxis Q15121 8682 1q23.2 human S104-p 455750 TKLTRIPsAKKYKDI molecular association, regulation; intracellular localization; protein conformation carcinogenesis, induced; cell motility, induced; apoptosis, inhibited; transcription, induced; autophagy, altered; signaling pathway regulation FADD(INDUCES) 17700518; 20452983; 21285289; 30569123; 34241740; 34615962; 34997083 13 27 322 +CELF1 CELF1 Cell development/differentiation; RNA processing; RNA-binding Q92879 10658 11p11.2 human S302-p 3347301 TSSGSSPsSSSSNSV molecular association, regulation RNA splicing, altered; translation, altered; translation, induced eIF2-beta(INDUCES); eIF2-alpha(INDUCES); Elf-2(INDUCES) RNA(INDUCES); RNA(DISRUPTS) 18570922; 24151077; 26100016; 31383751 6 1 0 5'-UTR of p53 mRNA; increases CUGBP1 binding to C/EBP beta and p21 mRNAs ; phosphorylation induces binding to active elf2; translational CUGBP1-eIF2 complexes during normal muscle differentiation; splicing regulation in diabetes +NCOR1 N-CoR1 Nuclear receptor co-regulator; Transcription, coactivator/corepressor O75376 9611 17p12-p11.2 human S2436-p 468249 SAQYETLsDSDD___ protein stabilization; molecular association, regulation carcinogenesis, induced; transcription, inhibited DNA(INDUCES) 22675025 1 19 5 needed for transcriptional repression of IP-10 protein +PGR PR DNA-binding; Nuclear receptor; Transcription factor P06401 5241 11q22.1 human R637-me 1876957800 AGMVLGGrKFKKFNK protein degradation; receptor recycling, induced cell motility, induced; cell growth, induced; transcription, induced 32563156 1 0 0 +ERG ERG DNA-binding; Oncoprotein; Transcription factor P11308 2078 21q22.2 human K355-me 1875818000 ARRWGERkSKPNMNY Ets activity, induced; molecular association, regulation; protein conformation carcinogenesis, induced; cell growth, induced; transcription, induced DNA(INDUCES) 34230470 1 0 0 +MAP3K5 ASK1 EC 2.7.11.25; KINASE; Kinase, protein; Protein kinase, STE; Protein kinase, Ser/Thr (non-receptor) Q99683 4217 6q23.3 human T842-p 450004 CTETFTGtLQYMAPE Pkinase transcription, altered 17937911 3 0 0 +YWHAZ 14-3-3 zeta Adaptor/scaffold; Motility/polarity/chemotaxis P63104 7534 8q22.3 human K120-ac 3649468 ESKVFYLkMKGDYYR 14-3-3 molecular association, regulation apoptosis, induced KIF11(DISRUPTS); ATG9A(DISRUPTS); AS160(DISRUPTS); BAD(DISRUPTS) 25770209 1 6 10 +Abl1 Abl EC 2.7.10.2; KINASE; Kinase, protein; Oncoprotein; Protein kinase, TK; Protein kinase, tyrosine (non-receptor) P00520 11350 2 21.86 cM|2 B mouse Y393-p 450298 RLMTGDTyTAHAGAK PK_Tyr_Ser-Thr phosphorylation; enzymatic activity, induced cytoskeletal reorganization; signaling pathway regulation 10964922; 11847100; 12748290; 31914386 24 49 1642 induces phosphorylation of Doublecortin, induces Abl/Dcx signaling and hence neuritogenesis +Nfkbie IkB-epsilon DNA-binding; Inhibitor O54910 18037 17|17 B3 mouse S18-p 455580 ADDSQCDsGIESLRS protein degradation 10497169 1 6 6 +Tbk1 TBK1 EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, Other; Protein kinase, Ser/Thr (non-receptor) Q9WUN2 56480 10|10 D2 mouse K401-ub 31033006 YEKISLPkIHPRYDL TBK1_CCD1 autophagy, induced 33164878 3 1 0 Parkin mediated mitophagy +PDE4D PDE4D iso2 EC 3.1.4.53; Nucleotide Metabolism - purine; Phosphodiesterase Q08499-2 5144 5q11.2-q12.1 human S54-p 458388 VHSQRREsFLYRSDS enzymatic activity, induced 15131123; 16973330; 20106966; 8663227 10 21 1 +H1-4 H1E DNA-binding P10412 3008 6p22.2 human S36-p 456059 GAAKRKAsGPPVSEL cell cycle regulation DNA(DISRUPTS) 21852232 2 70 36 contributes to mitotic progression; dissociates from mitotic chromatin +NTRK1 TrkA iso2 EC 2.7.10.1; KINASE; Kinase, protein; Membrane protein, integral; Oncoprotein; Protein kinase, TK; Protein kinase, tyrosine (receptor) P04629-2 4914 1q23.1 human Y670-p 449759 FGMSRDIySTDYYRV PK_Tyr_Ser-Thr enzymatic activity, induced 9099755 3 2 12 +Kcnb1 Kv2.1 Channel, cation; Channel, ligand-gated; Channel, potassium; Membrane protein, integral; Membrane protein, multi-pass P15387 25736 3q42 rat S607-p 473555 EATRFSHsPLASLSS Kv2channel intracellular localization; activity, inhibited neural plasticity 16917065; 21712386 7 6 0 regulates clustering/ regulating Kv2.1 channels; regulating neuronal function +Fer Fer EC 2.7.10.2; KINASE; Kinase, protein; Oncoprotein; Protein kinase, TK; Protein kinase, tyrosine (non-receptor) P70451 14158 17|17 E1.1 mouse Y402-p 457934 EPPPVVNyEEDARSV cell cycle regulation; cell motility, altered 18515860 2 39 613 +ARID4A RbBP1 Adaptor/scaffold P29374 5926 14q23.1 human K418-sm 12004425 HHHEPKVkEEKKDLE cell cycle regulation; cell growth, inhibited; transcription, inhibited 16479010 1 0 0 +MYLK smMLCK EC 2.7.11.18; KINASE; Kinase, protein; Protein kinase, CAMK; Protein kinase, Ser/Thr (non-receptor) Q15746 4638 3q21.1 human Y464-p 451414 QEGSIEVyEDAGSHY I-set molecular association, regulation; enzymatic activity, induced Cortactin(INDUCES) 11113114; 12408982 3 1 0 +Nphs1 NPHS1 Cell adhesion; Immunoglobulin superfamily; Membrane protein, integral Q9R044 64563 1q21 rat Y1153-p 1317600 AEVDPNYySMRDFSP cytoskeletal reorganization PIK3R1(INDUCES) 18033240 2 0 0 +Vim Vimentin Cytoskeletal; Motility/polarity/chemotaxis P20152 22352 2 A1|2 10.04 cM mouse S87-p 2301101 LQDSVDFsLADAINT Filament_head cytoskeletal reorganization 12458200 2 7 0 +HNF1A HNF1A DNA-binding; Transcription factor P20823 6927 12q24.31 human S249-p 451310 IQRGVSPsQAQGLGS molecular association, regulation transcription, induced DNA(INDUCES) 24821553 2 3 0 Regulates gluconeogenesis +Arc ARG3.1 Cytoskeletal; Motility/polarity/chemotaxis Q63053 54323 7q34 rat S206-p 149319101 PGEDGQPsPGVDTQI intracellular localization 28736134 1 0 0 cytosolic localization of Arc in hippocampal neurons +H3C1 H3 DNA-binding P68431 8350 6p22.2 human T11-p 455680 KQTARKStGGKAPRK Histone protein degradation; molecular association, regulation; acetylation; methylation; intracellular localization cell cycle regulation; DNA repair, induced; transcription, induced; transcription, inhibited; transcription, altered RNF8(INDUCES); H3(INDUCES); GCN5(INDUCES) 18243098; 20948546; 23844048; 28507061; 32112098 17 5 0 Acetylated MORC2 at K767 binds to H3T11P, downregulation of H3T11P and transcriptional repression of CDK1 and Cyclin B1 +NPM1 NPM1 Nucleolus; Oncoprotein; RNA-binding; Translation P06748 4869 5q35.1 human K292-ac 8537511 QDLWQWRkSL_____ NPM1-C molecular association, regulation; intracellular localization transcription, altered H3(INDUCES) 19581289 1 1 0 K212/215/229/230/257/267/292R mutant +NLRP3 NLRP3 Inhibitor Q96P20 114548 1q44 human S295-p 57761902 HKIVRKPsRILFLMD NACHT activity, inhibited 27548431 4 2 0 +TNC TNC Motility/polarity/chemotaxis; Secreted; Secreted, signal peptide P24821 3371 9q33.1 human K1882-ub 1877447401 KSSTITAkFTTDLDS protein degradation autophagy, induced 32732922 1 1 0 defective autophagy is key immunosuppressive factor in TNBC tumours +Sufu SUFU Adaptor/scaffold; Transcription, coactivator/corepressor; Tumor suppressor Q9Z0P7 24069 19 C3|19 38.85 cM mouse S342-p 4786843 LTHDRAPsRKDSLGS SUFU_C intracellular localization Exportin-1(DISRUPTS) 27849569 4 13 0 nuclear localization +Olig2 OLIG2 Oncoprotein; Transcription factor Q9EQW6 50913 16 C3.3|16 52.6 cM mouse K27-sm 1869334002 LFLPARSkGGSSSGF molecular association, regulation cell cycle regulation; carcinogenesis, induced; apoptosis, inhibited; DNA repair, inhibited; transcription, inhibited HDAC1(INDUCES) DNA(INDUCES) 32483381 1 1 0 +PINK1 PINK1 EC 2.7.11.1; KINASE; Kinase, protein; Membrane protein, integral; Mitochondrial; Protein kinase, Other; Protein kinase, Ser/Thr (non-receptor) Q9BXM7 65018 1p36.12 human T313-p 23003808 EGLGHGRtLFLVMKN Pkinase enzymatic activity, induced 22238344 1 1 0 contributes to activation, regulation of mitochondrial transport, abnormal mitochondrial distribution in neurons +TP63 p63 DNA-binding; Transcription factor Q9H3D4 8626 3q28 human S162-p 451601 TFDALSPsPAIPSNT protein stabilization; intracellular localization 23420876 6 2 0 nuclear stabilization of phosphorylated p63 in response to paclitaxel, partially relocates to the mitochondria +CCAR2 DBC-1 Apoptosis; Mitochondrial; Nuclear receptor co-regulator; RNA-binding; Tumor suppressor Q8N163 57805 8p21.3 human K215-ac 11324960 GGEPWGAkKPRHDLP molecular association, regulation; intracellular localization apoptosis, induced; transcription, inhibited SIRT1(DISRUPTS) 23892437; 24126058 2 4 0 +CSF2RB CSF2RB Membrane protein, integral; Receptor, cytokine P32927 1439 22q12.3 human K473-ub 57676503 YGYRLRRkWEEKIPN protein degradation 24086733 1 0 0 +PAK2 PAK2 EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, STE; Protein kinase, Ser/Thr (non-receptor) Q13177 5062 3q29 human S141-p 448295 TVKQKYLsFTPPEKD enzymatic activity, induced carcinogenesis, induced; cell adhesion, induced; apoptosis, inhibited; transcription, induced; signaling pathway regulation 21177766; 35986102; 36319849 17 84 76 induces the MAPK pathway +DNMT1 DNMT1 Amino Acid Metabolism - cysteine and methionine; Cell development/differentiation; EC 2.1.1.37; METHYLTRANSFERASE; Methyltransferase; Methyltransferase, DNA; Transcription regulation P26358 1786 19p13.2 human K1117-ac 474640 GKGKGKGkGKPKSQA cell cycle regulation; transcription, inhibited 21947282 1 1 19 +Dok1 DOK1 Adaptor/scaffold; Motility/polarity/chemotaxis P97465 13448 6 C3|6 35.94 cM mouse Y376-p 448368 PAPPRGLyDLPQEPR cell cycle regulation; cell motility, altered 18515860 2 12 356 +Eif4e EIF4E Translation; Translation initiation P63073 13684 3 G3|3 64.3 cM mouse S209-p 447776 DTATKSGsTTKNRFV molecular association, regulation; protein conformation carcinogenesis, induced; cell motility, induced; signaling pathway regulation; neural plasticity; translation, altered; apoptosis, inhibited; translation, induced; cell growth, altered; translation, inhibited eIF4G(INDUCES); CTNNB1(INDUCES) RNA(INDUCES) 18055695; 20679199; 22544393; 24909168; 25915475; 31968247; 34032633; 35842012; 35877722; 37250335; 9878069 64 4 0 regulates Wnt signaling pathway +HES1 HES1 Cell development/differentiation; Motility/polarity/chemotaxis; Transcription factor Q14469 3280 3q29 human K86-ub 22245547 DILEMTVkHLRNLQR HLH protein degradation cell differentiation, induced 29070679 1 1 0 +SERPINA3 SERPINA3 Secreted; Secreted, signal peptide P01011 12 14q32.13 human K416-ac 464676 QNIFFMSkVTNPKQA Serpin molecular association, regulation DNA(INDUCES) 7782318 1 0 0 +AKT1 Akt1 EC 2.7.11.1; KINASE; Kinase, protein; Oncoprotein; Protein kinase, AGC; Protein kinase, Ser/Thr (non-receptor) Q01314 280991 cow S473-p 447855 RPHFPQFsYSASATA Pkinase_C activity, induced; intracellular localization; enzymatic activity, induced cell growth, altered 12167717; 16195541 1956 25 44 Translocation to the plasma membrane leads to phosphorylation. ; PI3K, Akt and mTOR activation are required for 5-HT-induced proliferatioin. Wortmanin LY294002 and NL-71-101 dose-dependently inhibited 5HT induced proliferation. +IRAK4 IRAK4 EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, Ser/Thr (non-receptor); Protein kinase, TKL Q9NWZ3 51135 12q12 human S8-p 2859004 MNKPITPsTYVRCLN molecular association, regulation; protein conformation MYD88(INDUCES) 27876844 2 2 0 interferes with the Myddosome formation +RPS6KA6 RSK4 EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, AGC; Protein kinase, Ser/Thr (non-receptor) Q9UK32 27330 Xq21.1 human S372-p 457601 TAKTPKDsPGLPASA Pkinase_C enzymatic activity, induced 15632195 1 7 1 +NDE1 NUDE1 iso1 Cell cycle regulation; Cytoskeletal; Microtubule-binding Q9NXR1-1 54820 16p13.11 human T215-p 469489 ATGSVPStPIAHRGP NUDE_C molecular association, regulation; intracellular localization ZNF365(DISRUPTS) 16682949 1 6 6 +Cdh5 CDH5 Cell adhesion; Membrane protein, integral; Motility/polarity/chemotaxis P55284 12562 8 D3|8 53.04 cM mouse S776-p 13258704 MLAELYGsDPQEELI molecular association, regulation PAR3(INDUCES) 20047332 1 0 0 enhances PDZ-ligand interactions +PTH PTH Apoptosis; Hormone; Secreted; Secreted, signal peptide P01270 5741 11p15.3 human S34-p 23135905 SVKKRSVsEIQLMHN Parathyroid molecular association, regulation signaling pathway regulation PTHR(INDUCES) 25158085 1 1 11 +VIM Vimentin Cytoskeletal; Motility/polarity/chemotaxis P08670 7431 10p13 human S51-p 449416 LRPSTSRsLYASSPG Filament_head molecular association, regulation cytoskeletal reorganization Vimentin(DISRUPTS) 11895474 5 49 50 +Prkch PKCH EC 2.7.11.13; KINASE; Kinase, protein; Protein kinase, AGC; Protein kinase, Ser/Thr (non-receptor) P23298 18755 12|12 C3 mouse S317-p 7445167 GLQPGNIsPTSKLIS molecular association, regulation; intracellular localization CTLA-4(INDUCES) 24705298 1 12 0 +Vav1 VAV1 GEF; GEF, Rac/Rho; Motility/polarity/chemotaxis; Oncoprotein P27870 22324 17 D|17 29.76 cM mouse Y544-p 33373900 RGTFYQGyRCYRCRA C1_1 activity, induced 24736456 1 1 0 based on a lower activity of Y->F mutant in Jurkat cells stimulated by anti-CD3 antibody +FOXM1 FOXM1 DNA-binding; Transcription factor Q08050 2305 12p13.33 human K201-sm 31898500 GLGSRSIkQEMEEKE protein degradation; ubiquitination; intracellular localization cell cycle regulation; cell growth, inhibited; transcription, inhibited 24362530 2 1 0 +RBL1 Rb-like 1 Transcription, coactivator/corepressor; Tumor suppressor P28749 5933 20q11.23 human T369-p 451295 KRSFAPStPLTGRRY molecular association, regulation cell growth, altered E2F4(DISRUPTS) 11884610; 12006580 2 15 35 +IFNAR2 IFNAR2 Membrane protein, integral; Receptor, cytokine P48551 3455 21q22.11 human Y512-p 3063304 DVDLGDGyIMR____ activity, induced; molecular association, regulation; phosphorylation transcription, induced; signaling pathway regulation; transcription, altered STAT2(DISRUPTS) 11682488; 12105218; 20038197; 34813358 5 0 0 STAT phosphorylation and activation; lack of STAT1, 2, 3 phosphorylation in IFNAR2 Y337/512F mutant; induces STAT phosphorylation and signaling; IFN induced STAT activation and induced transcription +CUL3 CUL3 Cell cycle regulation; UBIQUITIN LIGASE; Ubiquitin conjugating system; Ubiquitin ligase Q13618 8452 2q36.2 human Y764-p 25180500 TPEDRKVyTYVA___ intracellular localization 22448038 1 0 0 +Snap23 SNAP23 Vesicle O09044 20619 2 60.37 cM|2 E5 mouse S95-p 455262 NRTKNFEsGKNYKAT SNAP-25 protein stabilization; molecular association, regulation exocytosis, altered; exocytosis, induced STX11(INDUCES) 18692471; 23613522; 25083866; 25176657 14 4 2 granule exocytosis (mast cell degranulation); required for IKK2-mediated mast cells degranulation; membrane fusion, SNARE complex formation, hemostasis; stabilizes SNARE complex, important for phagosomal MHC-1 accumulation and cross-presentation +Creb1 CREB iso1 DNA-binding; Transcription factor P15337-1 81646 9q32 rat S117-p 451810 DSQESVDsVTDSQKR pKID protein degradation 16782881 5 0 0 required for PDGF-induced protein ubiquitination +Rps6ka5 MSK1 EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, AGC; Protein kinase, Ser/Thr (non-receptor) Q8C050 73086 12|12 E mouse S375-p 448216 ERLFQGYsFVAPSIL Pkinase_C enzymatic activity, induced 17196532 23 19 41 +MAP1LC3B LC3B Autophagy; Microtubule-binding; Ubiquitin-like modifier; Vesicle Q9GZQ8 81631 16q24.2 human K49-ac 1881371300 KQLPVLDkTKFLVPD protein stabilization autophagy, inhibited 34590387 1 1 0 compromises LC3B lipidation in vitro and in HeLa cells, which leads to deficiency in the formation of autophagic structures and autophagic degradation +NLGN4X NLGN4X Membrane protein, integral Q8N0W4 57502 Xp22.32-p22.31 human T707-p 40245512 KDKRRHEtHRRPSPQ cell growth, induced 25675530 1 1 0 induces synaptogenesis +IGF2BP2 IGF2BP2 RNA-binding; Translation Q9Y6M1 10644 3q27.2 human K497-sm 580826994 GRIFGKLkEENFFNP protein stabilization cell growth, induced 34345216 1 1 0 promotes vasculogenic mimicry (VM) formation in glioma cells +ARRB1 ARRB1 Adaptor/scaffold P49407 408 11q13.4 human S163-p 31894300 EKIHKRNsVRLVIRK Arrestin_N activity, induced; molecular association, regulation CD3Z(INDUCES) 24502978 1 1 0 +Tp53 p53 Activator; DNA-binding; Motility/polarity/chemotaxis; Nuclear receptor co-regulator; Transcription factor; Tumor suppressor P10361 24842 10q24 rat S376-p 447534 TKKGQSTsRHKKPMI activity, induced; activity, inhibited apoptosis, inhibited 11574421; 35850611 15 2 0 Tolfenamic acid decreased the apoptotic positive cellular rate from 11.91 to 7.47%; tolfenamic acid significantly increased the phosphorylation level of p53 at the Ser378 site andreduced the acetylation level at the Lys382 site site, suggesting that tolfenamic acid may reduce the activity of p53 +FKBP5 FKBP5 Chaperone; EC 5.2.1.8; Isomerase Q13451 2289 6p21.31 human K28-ac 63115301 QGEDITSkKDRGVLK molecular association, regulation carcinogenesis, altered; apoptosis, induced PHLPP(DISRUPTS); Akt1(DISRUPTS) 28147277 1 1 0 induces Akt phosphorylation at S473 and enzymatic activation, regulates cancer cell sensitivity to genotoxic agents +PI4KB PIK4CB Carbohydrate Metabolism - inositol phosphate; EC 2.7.1.67; Kinase, lipid; Motility/polarity/chemotaxis Q9UBF8 5298 1q21.3 human S294-p 457621 SNLKRTAsNPKVENE molecular association, regulation; intracellular localization ERK1 iso3(INDUCES) 26459638; 33090289 7 38 9 regulation of myocellular glucose uptake, redulation of insulin-resistance in cardiomyocytes +ITGB4 ITGB4 Cell adhesion; Membrane protein, integral; Motility/polarity/chemotaxis; Receptor, misc. P16144 3691 17q25.1 human Y1492-p 450140 SSTLTRDyNSLTRSE molecular association, regulation Syk(INDUCES) 25531330 3 0 72 +DYRK2 DYRK2 iso2 EC 2.7.12.1; KINASE; Kinase, protein; Protein kinase, CMGC; Protein kinase, dual-specificity (non-receptor) Q92630-2 8445 12q15 human T488-p 1874397814 TESTGAItSISKLPP cell cycle regulation; apoptosis, induced 34363019 1 1 0 +SLC25A5 SLC25A5 Membrane protein, integral; Membrane protein, multi-pass; Mitochondrial; Transporter; Transporter, SLC family P05141 292 Xq24 human Y195-p 458470 RAAYFGIyDTAKGML Mito_carr; TM molecular association, regulation NCK2(NOT_REPORTED) 23322602 0 14 136 +EPS8 EPS8 Adaptor/scaffold Q12929 2059 12p12.3 human Y252-p 462061 DFEKPRQyHEQEETP molecular association, regulation IRS4(INDUCES) 23626693 1 3 3 +KRT8 K8 Cytoskeletal P05787 3856 12q13.13 human K364-sm 25027601 EAALQRAkQDMARQL Filament cytoskeletal reorganization 21062750 1 2 0 sumoylation regulate solubility; modified by poly-SUMO-2/3 chains, oxidative stress, apoptosis, and/or phosphatase inhibition increase sumoylation in primary hepatocytes; K to R mutants show filament disorganization +RAB7A Rab7 G protein; G protein, monomeric; G protein, monomeric, Rab P51149 7879 3q21.3 human K38-ub 12322359 KKFSNQYkATIGADF Ras molecular association, regulation; intracellular localization endocytosis, induced RILP(INDUCES) 26911690 1 8 5 +EIF4E EIF4E Translation; Translation initiation P06730 1977 4q23 human T210-p 450199 TATKSGStTKNRFVV cell growth, altered 15574771 3 2 0 S209A/T210A mutant showed reduced transport of cyclin D1 mRNA from nucleus to cytoplasm. eiF4E cellular distribution not affected by phosphorylation. +CHAT CHAT iso3 ACETYLTRANSFERASE; Acetyltransferase; EC 2.3.1.6; Lipid Metabolism - glycerophospholipid P28329-3 1103 10q11.23 human S347-p 454036 LKHVTQSsRKLIRAD Carn_acyltransf enzymatic activity, induced 15381704 1 0 0 +PKM PKM Carbohydrate Metabolism - glycolysis and gluconeogenesis; Carbohydrate Metabolism - pyruvate; EC 2.7.1.40; KINASE; Kinase, other; Mitochondrial; Nucleotide Metabolism - purine P14618 5315 15q23 human T365-gl 1879953201 CIMLSGEtAKGDYPL enzymatic activity, inhibited cell growth, induced PKM(DISRUPTS) 31501520 1 0 0 O-GlcNAcylation of PKM inhibits its catalytic activity and tetramerization +TSC2 TSC2 Cell cycle regulation; GAP; GAP, misc.; Nuclear receptor co-regulator; Tumor suppressor P49815 7249 16p13.3 human S1130-p 448499 GARDRVRsMSGGHGL activity, inhibited 27451907 3 16 13 cell survival induced +Trpv2 TRPV2 Channel, cation; Membrane protein, integral; Membrane protein, multi-pass Q9WUD2 29465 10q23 rat Y471-p 1877505002 WISFMDSyFEILFLL Ion_trans activity, induced; protein stabilization endocytosis, induced 35686730 1 0 0 +PDPK1 PDK1 EC 2.7.11.1; KINASE; Kinase, protein; Nuclear receptor co-regulator; Protein kinase, AGC; Protein kinase, Ser/Thr (non-receptor) O15530 5170 16p13.3 human S398-p 12729601 SSSSHSLsASDTGLP apoptosis, altered; cell growth, altered 19920149 2 0 0 +PIAS1 PIAS1 EC 6.3.2.-; Nuclear receptor co-regulator; SUMO LIGASE; SUMO conjugating system; SUMO ligase; Transcription, coactivator/corepressor O75925 8554 15q23 human R303-m2 6742810 RLRAKGIrNPDHSRA cell growth, inhibited; transcription, inhibited; signaling pathway regulation 19136629 1 1 0 negative regulation of STAT1 signaling/activation +Fbxw8 FBXW8 Cell development/differentiation; UBIQUITIN LIGASE; Ubiquitin conjugating system; Ubiquitin ligase Q8BIA4 231672 5|5 F mouse S86-p 4751099 DTSSRSRsPPDRDAT protein stabilization; intracellular localization 23142081 1 14 0 +Mob1a MOB1A Protein kinase, regulatory subunit Q921Y0 232157 6|6 C3 mouse T35-p 3212769 LLKHAEAtLGSGNLR Mob1_phocein carcinogenesis, inhibited; cell growth, inhibited 34678143 13 45 34 +Anxa2 ANXA2 Calcium-binding; Lipid-binding; Motility/polarity/chemotaxis Q07936 56611 8q24 rat Y24-p 449483 HSTPPSAyGSVKPYT ubiquitination; intracellular localization ACTB(INDUCES) 26644180 29 64 2613 nuclear pool of pTyr23AnxA2 is diminished and replaced by a cortical pool after H2O2 treatment, nuclear pTyr23AnxA2 is found in PML bodies +Ppp1r1b DARPP-32 Motility/polarity/chemotaxis; Protein phosphatase, regulatory subunit Q6J4I0 360616 10q31 rat S97-p 466340 LQTISNLsENQASEE DARPP-32 molecular association, regulation ADD2(INDUCES) 26639316 3 2 0 +STAR STAR Carrier; Lipid-binding; Mitochondrial P49675 6770 8p11.23 human S195-p 450442 RCAKRRGsTCVLAGM START activity, induced; molecular association, regulation; protein conformation 14-3-3 sigma(INDUCES); 14-3-3 epsilon(INDUCES); 14-3-3 gamma(INDUCES) 10548884; 32633081 9 1 0 +MC1R MC1R GPCR, family 1; Membrane protein, integral; Membrane protein, multi-pass; Receptor, GPCR Q01726 4157 16q24.3 human S316-p 471420 LKEVLTCsW______ receptor internalization, altered 17130136 1 0 0 T308 and S316 phosphorylation regulate MC1R internalization and desensitization. +HSPA1A HSP70 Chaperone; Heat shock protein; Motility/polarity/chemotaxis P0DMV8 3303 6p21.33 human K159-ac 31089500 DSQRQATkDAGVIAG HSP70 sumoylation autophagy, induced 23569248 1 1 0 acetylation induces sumoylation of PIK3C3 +MECOM EVI1 C2H2-type zinc finger protein; Methyltransferase, protein lysine, predicted; Oncoprotein; Transcription regulation; Transcription, coactivator/corepressor Q03112 2122 3q26.2 human S624-p 4702996 KMFKDKVsPLQNLAS molecular association, regulation; methylation transcription, altered DNMT3A(INDUCES); CTBP1(DISRUPTS) 33082307 1 13 0 induces hematopoietic-stem cell self renewal +Cacng2 Stargazin Channel, calcium; Membrane protein, integral; Membrane protein, multi-pass O88602 12300 15 E1|15 36.92 cM mouse S221-p 2047941 ATDYLQAsAITRIPS intracellular localization 20670832 1 4 0 AMPAR immobilization in synaptic membrane +Grk2 GRK2 EC 2.7.11.15; KINASE; Kinase, protein; Protein kinase, AGC; Protein kinase, Ser/Thr (non-receptor) Q99MK8 110355 19 A|19 3.98 cM mouse Y86-p 447727 AKPLVEFyEEIKKYE RGS cell motility, altered 18369319 5 0 0 +RAPH1 RAPH1 Adaptor/scaffold; Motility/polarity/chemotaxis Q70E73 65059 2q33.2 human Y510-p 477343 AKYGKQLyMNYQEAL molecular association, regulation cell motility, induced 26996666 1 0 1 Lpd-Scar/WAVE interaction is positively regulated by c-Abl and c-Src, breast cancer cell invasion +Mylk2 skMLCK EC 2.7.11.18; KINASE; Kinase, protein; Motility/polarity/chemotaxis; Protein kinase, CAMK; Protein kinase, Ser/Thr (non-receptor) P20689 117558 3q41 rat S168-p 2864200 PAFLHSPsCPAIISC molecular association, regulation 14-3-3 beta(INDUCES) 11795875 2 3 0 +MAPT Tau iso8 ACETYLTRANSFERASE; Acetyltransferase; Cytoskeletal P10636-8 4137 17q21.31 human S400-gl 18416102 VYKSPVVsGDTSPRH protein conformation; phosphorylation 34220449 3 3 0 regulates fibrillar assembly and aggregation; inhibits phosphorylation at S400 and S396 +Katna1 KATNA1 EC 3.6.4.3; Hydrolase; Motility/polarity/chemotaxis Q6E0V2 292464 rat K330-sm 1883544400 HEASRRVkAELLVQM cell growth, induced; cytoskeletal reorganization 35868557 1 1 0 K330 SUMOylation enhances hippocampal neurite outgrowth and promotes the microtubule severing activity of KATNA1. +CLSPN claspin Actin-binding; Cell cycle regulation Q9HAW4 63967 1p34.3 human T916-p 455334 DELLDLCtGKFTSQA molecular association, regulation chromatin organization, altered Chk1(INDUCES) 15707391; 16963448 3 0 0 regulates Chk1 activity in response to hydroxyurea +GCM1 GCM1 DNA-binding; Transcription factor Q9NP62 8521 6p12.1 human K406-ac 460588 QQYSLPSkSSKWDFE protein stabilization; ubiquitination transcription, induced 16166624 1 0 0 inhibits ubiquitination +FBXL20 FBXL20 UBIQUITIN LIGASE; Ubiquitin ligase Q96IG2 84961 17q12 human S425-p 4149424 PPPSVGGsRQRFCRC protein degradation; molecular association, regulation carcinogenesis, inhibited; cell growth, inhibited; apoptosis, induced FBXO31(INDUCES) 34587475 1 5 2 +PTK2 FAK EC 2.7.10.2; KINASE; Kinase, protein; Protein kinase, TK; Protein kinase, tyrosine (non-receptor) Q05397 5747 8q24.3 human Y407-p 447888 IIDEEDTyTMPSTRD enzymatic activity, induced cell motility, altered; cytoskeletal reorganization; cell adhesion, altered 15561106; 15735019; 16760434 28 13 139 +GAPDH GAPDH Carbohydrate Metabolism - glycolysis and gluconeogenesis; EC 1.2.1.12; Oxidoreductase P04406 2597 12p13.31 human K139-ub 21175144 VMGVNHEkYDNSLKI activity, induced; molecular association, regulation cell motility, induced; cell growth, induced TRAF2(INDUCES) 37450367 1 6 0 K139 ubiquitylation promotes cell proliferation and motility-migration and metastasis; K139 is critical for its binding to TRAF2 and activation of the NF-kB pathways leading to proliferation and migration +Nfya NFYA DNA-binding; Transcription factor P23708 18044 17 C|17 23.99 cM mouse K283-ac 4659500 KRRQARAkLEAEGKI CBFB_NFYA cell growth, induced; transcription, induced 18815279 1 0 0 +ITGAX ITGAX Membrane protein, integral; Motility/polarity/chemotaxis P20702 3687 16p11.2 human S1158-p 29606704 ENGTQTPsPPSEK__ activity, induced cell adhesion, induced 24129562 1 0 0 inside-out activation, phagocytosis +Pikfyve PIKFYVE Carbohydrate Metabolism - inositol phosphate; EC 2.7.1.150; KINASE; Kinase, lipid; Motility/polarity/chemotaxis; Protein kinase, Ser/Thr (non-receptor) Q9Z1T6 18711 1|1 C2 mouse S1548-p 4272931 DTSPRNIsPGLHNGE enzymatic activity, induced autophagy, induced 34107300 1 23 0 +KIF2C KIF2C Cancer Testis Antigen (CTA); Microtubule-binding; Motility/polarity/chemotaxis; Motor Q99661 11004 1p34.1 human S109-p 2132103 APKESLRsRSTRMST molecular association, regulation; intracellular localization; activity, inhibited cytoskeletal reorganization EB1(DISRUPTS) 14960279; 19632184 2 0 0 involved in microtubule tip tracking +SPSB1 SSB1 Adaptor/scaffold; Ubiquitin conjugating system Q96BD6 80176 1p36.22 human Y31-p 455116 QELQGLDyCKPTRLD molecular association, regulation RASA1(INDUCES) 15713673 1 0 0 +RBPJ RBPJ Cell development/differentiation; Transcription factor Q06330 3516 4p15.2 human T339-p 23298201 STDKAEYtFYEGMGP protein degradation; ubiquitination 22302987 1 0 0 +RGCC RGC32 iso2 Cell cycle regulation; Protein kinase, regulatory subunit Q9H4X1-2 28984 13q14.11 human T91-p 7105234 ALLSATVtPQKAKLG RGCC cell cycle regulation; cell growth, induced 35462050 2 8 1 +XRCC1 XRCC1 DNA repair, damage P18887 7515 19q13.31 human S371-p 458811 FANTPKYsQVLGLGG BRCT molecular association, regulation XRCC1(DISRUPTS) 16397295 1 0 1 +BCL2L1 Bcl-xL Apoptosis; Autophagy; Membrane protein, integral; Mitochondrial Q07817 598 20q11.21 human S62-p 449099 PSWHLADsPAVNGAT activity, induced; molecular association, regulation; intracellular localization; protein conformation cell cycle regulation; apoptosis, altered; cell growth, inhibited; apoptosis, induced BAK1(DISRUPTS); CDK1(DISRUPTS); CDK1(INDUCES); BAX(DISRUPTS) 12633850; 17369848; 18794113; 18974096; 20363734; 22617334; 24013390; 27398719; 28486788; 31367011; 34064109; 35436470 18 1 0 +Upf1 RENT1 C2H2-type zinc finger protein; EC 3.6.1.-; EC 3.6.4.-; Hydrolase; RNA-binding Q9EPU0 19704 8 B3.3|8 34.15 cM mouse S1084-p 12559503 GLSQPELsQDSYLGD molecular association, regulation STAU(INDUCES) 22503102 3 0 0 increases Stau1-mediated decay of mRNA; regulates adipogenesis +Chpt1 CHPT1 EC 2.7.8.2; Lipid Metabolism - ether lipid; Lipid Metabolism - glycerophospholipid; Membrane protein, integral; Membrane protein, multi-pass; Transferase Q8C025 212862 10|10 C1 mouse K292-ub 12718514 SATNMFEkHPCLYTL protein degradation; enzymatic activity, inhibited 20018880 1 0 0 +SH2B3 LNK Adaptor/scaffold Q9UQQ2 10019 12q24.12 human S150-p 14575499 RHIFRRRsAGELPAA molecular association, regulation signaling pathway regulation 14-3-3 zeta(INDUCES) 24704825 0 23 4 silencing of 14-3-3 enhances tumor growth in Nod-SCID mice injected with OVCAR5 cells expressing LNK +Card11 CARD11 Adaptor/scaffold Q8CIS0 108723 5|5 G2 mouse S657-p 457639 LERPFRPsVTSGGHV activity, induced; molecular association, regulation Bcl-10(INDUCES) 16356855; 19917688 6 0 0 +PSMA7 PSMA7 EC 3.4.25.1; Protease; Proteasome complex O14818 5688 20q13.33 human Y106-p 15570108 EDPVTVEyITRYIAS Proteasome protein stabilization; ubiquitination 25620702 1 2 1 +MSH2 MSH2 DNA-binding; Tumor suppressor P43246 4436 2p21-p16.3 human Y238-p 36121371 DFSTKDIyQDLNRLL MutS_II molecular association, regulation apoptosis, inhibited MSH6(DISRUPTS) 25978431 1 2 0 Enforced expression of MSH2 Y238F induces spontaneous apoptosis +CBL CBL Adaptor/scaffold; EC 6.3.2.-; EC 6.3.2.19; Ligase; Motility/polarity/chemotaxis; Oncoprotein; UBIQUITIN LIGASE; Ubiquitin conjugating system; Ubiquitin ligase P22681 867 11q23.3 human S619-p 4704596 RELTNRHsLPFSLPS molecular association, regulation 14-3-3 eta(INDUCES) 11024037 1 13 17 +FLT4 VEGFR3 EC 2.7.10.1; KINASE; Kinase, protein; Membrane protein, integral; Protein kinase, TK; Protein kinase, tyrosine (receptor) P35916 2324 5q35.3 human Y1337-p 2874406 QVFYNSEyGELSEPS molecular association, regulation; enzymatic activity, induced cell motility, induced; cell growth, induced SHC1(INDUCES); CRK(INDUCES) 16076871; 20431062 4 1 2 +ERCC6L PICH EC 3.6.4.12; Helicase Q2NKX8 54821 Xq13.1 human T1063-p 474544 VKQFDAStPKNDISP molecular association, regulation; intracellular localization BLM(INDUCES); TOP3A(INDUCES) 17218258; 36719798 2 4 4 +VIM Vimentin Cytoskeletal; Motility/polarity/chemotaxis P08670 7431 10p13 human T327-p 3180351 RRQVQSLtCEVDALK Filament carcinogenesis, induced; cell motility, induced; cell growth, induced 33963314 1 4 0 +RUFY1 RUFY1 Ubiquitin conjugating system Q96T51 80230 5q35.3 human Y400-p 451278 RQGLDEMySDVWKQL intracellular localization 11877430 1 1 23 +Esrra ERR1 DNA-binding; Nuclear receptor; Transcription regulation O08580 26379 19 A|19 5.08 cM mouse K14-sm 487493 GIEPLYIkAEPASPD transcription, inhibited 17676930; 18063693 2 1 0 +Map3k11 MLK3 EC 2.7.11.25; KINASE; Kinase, protein; Protein kinase, Ser/Thr (non-receptor); Protein kinase, TKL Q80XI6 26403 19 A|19 4.34 cM mouse S675-p 448790 LSRERGEsPTAPPPA enzymatic activity, inhibited 37085815 4 0 0 +INPP5D SHIP EC 3.1.3.86; Motility/polarity/chemotaxis; Phosphatase, lipid Q92835 3635 2q37.1 human Y865-p 454794 GKTREKLyDFVKTER molecular association, regulation SH2D1B(NOT_REPORTED) 23322602 1 25 364 +PDCD6IP Alix Adaptor/scaffold; Apoptosis Q8WUM4 10015 3p22.3 human S721-p 34504755 AREPSAPsIPTPAYQ molecular association, regulation cell cycle regulation Alix(DISRUPTS) 26859355 1 2 0 EIAV budding, cytokinetic abscission +SMC1A Smc1 DNA replication; RNA splicing Q14683 8243 Xp11.22 human S966-p 448698 GEDSVSGsQRISSIY SMC_N molecular association, regulation; intracellular localization cell cycle regulation; cytoskeletal reorganization RAE1(INDUCES) 11877376; 11877377; 18832153 20 15 67 +POLH POLH DNA repair, damage; EC 2.7.7.7; Transferase Q9Y253 5429 6p21.1 human K515-sm 1877365910 PMSNSPSkPSLPFQT intracellular localization; enzymatic activity, inhibited 32350109 1 1 0 +OPTN optineurin Inhibitor Q96CV9 10133 10p13 human S513-p 21214714 FEDGGRQsLMEMQSR ubiquitination; intracellular localization 26365381; 27035970 4 5 0 recruitment to depolarized mitochondria,TBK1 activation, mitophagy; recruitment to mitochondria +Trp53 p53 iso2 Activator; DNA-binding; Motility/polarity/chemotaxis; Nuclear receptor co-regulator; Transcription factor; Tumor suppressor Q80ZA1 22059 11 B3|11 42.83 cM mouse K317-ac 458976 SASPPQKkKPLDGEY P53_tetramer intracellular localization; protein conformation apoptosis, inhibited 22696202 56 2 0 induces localization and conformational activation of Bax +DDX5 DDX5 EC 3.6.4.13; Helicase; Nuclear receptor co-regulator; Nucleolus; RNA splicing; RNA-binding; Spliceosome P17844 1655 17q23.3 human K33-ac 466259 AGPLSGKkFGNPGEK protein stabilization; molecular association, regulation carcinogenesis, induced; transcription, induced HDAC1(INDUCES); HDAC2(INDUCES) 20663877 1 2 17 +FOXO1 FOXO1A DNA-binding; Nuclear receptor co-regulator; Oncoprotein; Transcription factor Q12778 2308 13q14.11 human T24-p 448560 LPRPRSCtWPLPRPE molecular association, regulation; intracellular localization; activity, inhibited; phosphorylation cell growth, induced; signaling pathway regulation; transcription, altered; transcription, inhibited 14-3-3 beta(INDUCES); 14-3-3 zeta(INDUCES); 14-3-3 gamma(INDUCES) DNA(DISRUPTS) 11237865; 12228231; 14664696; 15934941; 16670091; 20061393; 20519497; 22081023; 23995784; 26539823; 31308176 62 6 39 +Irak1 IRAK1 EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, Ser/Thr (non-receptor); Protein kinase, TKL B2RYH5 363520 Xq37 rat K397-ub 7452909 YLPEEYIkTGRLAVD Pkinase protein degradation 21708940 2 5 2 +PTPN22 PTPN22 EC 3.1.3.48; Motility/polarity/chemotaxis; PHOSPHATASE; Protein phosphatase, tyrosine (non-receptor) Q9Y2R2 26191 1p13.2 human S751-p 5963554 KSFTRSKsLKILRNM protein stabilization; molecular association, regulation; intracellular localization signaling pathway regulation CSK(INDUCES) 32184287 1 1 1 TCR signaling; Inhibits ubiquitination and protein degradation +Sipa1l1 SIPA1L1 GAP; GAP, Ras O35412 246212 6q24 rat T1348-p 26348504 SADSGIDtASYGLSH protein degradation; molecular association, regulation; ubiquitination BTRC(INDUCES) 18723513 1 1 0 +Mapk3 ERK1 EC 2.7.11.24; KINASE; Kinase, protein; Protein kinase, CMGC; Protein kinase, Ser/Thr (non-receptor) P21708 50689 1q36 rat T203-p 447542 HDHTGFLtEYVATRW Pkinase activity, induced; intracellular localization; enzymatic activity, induced translation, altered; cell adhesion, induced; signaling pathway regulation; cell growth, altered 10473611; 11731096; 12163549; 12595539; 14627993; 15757502; 16368189; 19427337; 19943942; 20096547; 21357465; 21738764; 21917714; 22076135; 34475824; 8387499 1343 110 2017 +PLK1 PLK1 EC 2.7.11.21; KINASE; Kinase, protein; Protein kinase, Other; Protein kinase, Ser/Thr (non-receptor) P53350 5347 16p12.2 human S137-p 448138 LELCRRRsLLELHKR Pkinase molecular association, regulation; intracellular localization; phosphorylation; enzymatic activity, induced cell cycle regulation; DNA repair, induced; cell growth, induced; apoptosis, inhibited Other(DISRUPTS) 12207013; 15713655; 19706541; 34197606 8 3 0 +Epha5 EphA5 EC 2.7.10.1; KINASE; Kinase, protein; Membrane protein, integral; Protein kinase, TK; Protein kinase, tyrosine (receptor) Q60629 13839 5 E1|5 43.0 cM mouse Y672-p 451542 EDDPEAAyTTRGGKI PK_Tyr_Ser-Thr cell cycle regulation; cell motility, altered 18515860 0 32 700 +BCL6 Bcl-6 C2H2-type zinc finger protein; Oncoprotein; Transcription factor P41182 604 3q27.3 human S333-p 447600 KGLVSPQsPQKSDCQ protein degradation 9649500 2 21 25 +FKBP5 FKBP5 Chaperone; EC 5.2.1.8; Isomerase Q13451 2289 6p21.31 human K422-sm 56400001 KFAEQDAkEEANKAM molecular association, regulation; intracellular localization transcription, inhibited; signaling pathway regulation HSP90A(INDUCES); GR(INDUCES) 27177020 1 1 0 regulation of GR and Hsp90 cochaperon activity +Bmal1 BMAL1 iso4 DNA-binding; Transcription factor Q9WTL8-4 11865 7 F1|7 59.17 cM mouse K538-ac 1968606 DASSPGGkKILNGGT activity, induced; molecular association, regulation transcription, altered CK2B(INDUCES) 26562092; 31150620 8 0 0 transcriptional oscillation, synchronization of circadian clocks in peripheral tissues ; inhibits S90 phosphorylation +Etv1 ETV1 DNA-binding; Oncoprotein; Transcription factor P41164 14009 12 A3|12 17.99 cM mouse S216-p 3059600 PMYQRQMsEPNIPFP ETS_PEA3_N activity, inhibited transcription, altered 10982847 3 3 2 in Mv1Lu cells (mutation shows no effect in HeLa cells) +ABI1 Abi-1 Adaptor/scaffold; Motility/polarity/chemotaxis Q8IZP0 10006 10p12.1 human S183-p 486178 PPTQKPPsPPMSGRG molecular association, regulation cell motility, altered; cytoskeletal reorganization 21419341 1 69 51 regulates WRC (WAVE2 regulatory complex) interaction with Arp2/3 and lamellipodial protrusion +SNCA SNCA Adaptor/scaffold P37840 6622 4q22.1 human K23-ub 466356 VAAAEKTkQGVAEAA Synuclein ubiquitination; phosphorylation 16847063 1 3 2 SNCA is phosphorylated, truncated, and then deposited to Lewy bodies.and then ubiquitinated which occurs at K12, K21. and K23 +KIZ Kizuna Cell cycle regulation Q2M2Z5 55857 20p11.23 human T379-p 469605 WSTSSDLtISISEDD cytoskeletal reorganization 16980960 1 0 0 stabilizes mitotic centrosomes +ITGA3 ITGA3 Cell adhesion; Membrane protein, integral; Motility/polarity/chemotaxis; Receptor, misc. P26006 3675 17q21.33 human S1042-p 447602 AEMKSQPsETERLTD molecular association, regulation; intracellular localization cytoskeletal reorganization; cell adhesion, altered 11179420 1 10 0 +Gabrg2 GABRG2 Channel, chloride; Channel, ligand-gated; Membrane protein, integral; Membrane protein, multi-pass; Transporter; Transporter, ion channel P22723 14406 11 A5|11 24.8 cM mouse K371-ub 11956713 PSKDKDKkKKNPLLR Neur_chan_memb protein degradation; receptor internalization, altered 19815531 1 0 0 regulation of the late endosomal/lysosomal trafficking of GABA receptors, regulation of synaptic transmission +DTD1 DTD1 DNA replication; EC 3.1.-.-; Hydrolase Q8TEA8 92675 20p11.23 human S197-p 1983955 KEDRSASsGAEGDVS molecular association, regulation cell cycle regulation; cell growth, induced MCM7(INDUCES); MCM3(DISRUPTS) 25258324 1 49 1 decreases DTD1 incorporation into HMW, supports DNA replication initiation +Ms4a2 FcER1B Membrane protein, integral; Membrane protein, multi-pass; Receptor, misc. P13386 25316 1q43 rat Y218-p 454405 KVPDDRLyEELHVYS molecular association, regulation GRB2(INDUCES); SHIP(INDUCES); Syk(INDUCES); SHC1(INDUCES); SHP-1(INDUCES) 17365510 2 1 0 SHIP binding is senstive to the presence of Syk. +CTNNB1 CTNNB1 Actin-binding; Cell adhesion; Motility/polarity/chemotaxis; Nuclear receptor co-regulator; Oncoprotein; Transcription factor P35222 1499 3p22.1 human K133-m1 1873284336 AEPSQMLkHAVVNLI molecular association, regulation; intracellular localization carcinogenesis, induced; cell growth, induced; transcription, induced; signaling pathway regulation FOXM1(INDUCES); CTNNA1(DISRUPTS) 28915556 1 1 0 WNT/Beta-Catenin/TCF pathway +Kif21a KIF21A Microtubule-binding; Motor Q9QXL2 16564 15 E3|15 45.86 cM mouse T1160-p 487344 NKARRRTtTQMELLY molecular association, regulation ANKRD15(DISRUPTS) 29158259 1 0 4 +Mapk8ip1 JIP1 Adaptor/scaffold Q9WVI9 19099 2|2 E1 mouse S417-p 458259 DNCASASsPYESAIG molecular association, regulation cell motility, induced KIF5A(INDUCES) 23897889 3 1 0 increased anterograde amyloid precursor protein (APP) transport, decreased retrograde run length +NIBAN1 NIBAN1 Unknown function Q9BZQ8 116496 1q25.3 human S602-p 467580 ASPARRAsAILPGVL apoptosis, inhibited NPM1(INDUCES) 22510990 1 41 26 FAM129 phosphorylation disrupts binding of NPM to MDM2 and promotes MDM2-p53 interaction, leading to p53 degredation. +KDR VEGFR2 EC 2.7.10.1; KINASE; Kinase, protein; Membrane protein, integral; Protein kinase, TK; Protein kinase, tyrosine (receptor) P35968 3791 4q12 human Y1175-p 447901 AQQDGKDyIVLPISE molecular association, regulation; enzymatic activity, induced; phosphorylation carcinogenesis, induced; cell growth, induced; cell motility, induced; cell motility, inhibited; transcription, altered; signaling pathway regulation; cell growth, altered PLCG1(INDUCES); NRP1(INDUCES); SHC1(INDUCES); SHC2(INDUCES); SHB(INDUCES) 10749680; 11103941; 11387210; 12214271; 14532277; 15026417; 17110601; 17303569; 21653826; 21893193; 25119572; 35081345 40 0 0 +UBTF UBF DNA-binding; Nucleolus; Transcription factor P17480 7343 17q21.31 human S412-p 472620 EKPKRPVsAMFIFSE HMG_box molecular association, regulation cell growth, induced; transcription, induced ECT2(INDUCES) 32350115 1 10 1 +CLIC5 CLIC5 Membrane protein, integral; Motility/polarity/chemotaxis Q9NZA1 53405 6p21.1 human Y33-p 3081200 EENESPHyDDVHEYL activity, induced; molecular association, regulation Fyn(INDUCES) 10930415 1 0 0 +Agtr1 AT1 GPCR, family 1; Membrane protein, integral; Membrane protein, multi-pass; Receptor, GPCR P25095 24180 17p12 rat S348-p 452093 PSDNMSSsAKKPASC activity, induced 16831865 2 0 0 +Dlg4 PSD-95 Adaptor/scaffold P31016 29495 10q24 rat S418-p 456447 LMNSSLGsGTASLRS protein conformation CRIPT(DISRUPTS) 21965656 1 11 1 Y397E mutant showed dissociation, triple mutant Y397E/S415E/S418E showed stronger dissociation +POLR1G ASE-1 Nucleolus; Transcription initiation complex O15446 10849 19q13.32 human Y80-p 11382803 LAGKRHRyRVLSSCP RNA_polI_A34 molecular association, regulation transcription, induced; transcription, altered CD3E(DISRUPTS) 10373416; 16809778 2 0 0 Y80 phosphorylation is associated with an initiation-competent Pol1B complex. +HIF1A HIF1A Autophagy; DNA-binding; Transcription factor Q16665 3091 14q23.2 human R258-m2 1881582605 KFSYCDErITELMGY carcinogenesis, induced 34753906 1 0 0 RMT3-mediated tumor angiogenesis +RGS2 RGS2 GAP; GAP, RGS P41220 5997 1q31.2 human S64-p 10772901 KPKTGKKsKQQAFIK activity, induced; molecular association, regulation; intracellular localization G-alpha i3(INDUCES) 14608379; 24777815 2 0 0 RGS2 phosphorylation increases G-alpha GTPase activity, and association with membrane fraction. ; inhibits CPA-induced hydrolysis +H2AFZ H2AZ DNA-binding Q5ZMD6 426361 chicken K4-ac 458911 ____AGGkAGKDSGK Histone chromatin organization, altered 19385636 4 14 250 K4, K7, and K11 acetylation destabilizes the nucleosome core particle (NCP) +Upf1 RENT1 C2H2-type zinc finger protein; EC 3.6.1.-; EC 3.6.4.-; Hydrolase; RNA-binding Q9EPU0 19704 8 B3.3|8 34.15 cM mouse S1102-p 456314 SQIDVALsQDSTYQG molecular association, regulation STAU(INDUCES) 22503102 5 51 45 increases Stau1-mediated decay of mRNA; regulates adipogenesis +Rorc RORC iso2 DNA-binding; Nuclear receptor; Transcription factor P51450-2 19885 3|3 F2.1 mouse K69-ub 206219716 CQHCRLQkCLALGMS zf-C4 cell differentiation, induced 28846085 1 0 0 +LCK Lck EC 2.7.10.2; KINASE; Kinase, protein; Oncoprotein; Protein kinase, TK; Protein kinase, tyrosine (non-receptor) P06239 3932 1p35.2 human Y394-p 447822 RLIEDNEyTAREGAK PK_Tyr_Ser-Thr molecular association, regulation; intracellular localization; protein conformation; enzymatic activity, induced carcinogenesis, induced; DNA repair, induced; cell growth, induced; transcription, induced; cell growth, altered Lck(INDUCES) 10962552; 11828322; 14623872; 18541536; 19776125; 20541955; 23202272; 29989005; 35638332; 36372231 62 96 2957 +Traf3ip2 TRAF3IP2 Apoptosis; UBIQUITIN LIGASE; Ubiquitin conjugating system; Ubiquitin ligase Q8N7N6 103213 10|10 B1 mouse S209-p 25687506 ERPLPLTsSCYLQDL molecular association, regulation transcription, inhibited TRAF6(DISRUPTS) 22851696 1 0 0 +Map4k1 HPK1 EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, STE; Protein kinase, Ser/Thr (non-receptor) P70218 26411 7|7 B1 mouse Y379-p 448160 LSDSDDDyDDVDIPA molecular association, regulation; enzymatic activity, induced transcription, altered SLP76(INDUCES); BLNK(INDUCES) 11487585; 11514608 2 1 0 +CLOCK CLOCK ACETYLTRANSFERASE; Acetyltransferase; DNA-binding; EC 2.3.1.48; Transcription factor O15516 9575 4q12 human S427-p 7911903 ALERFDHsPTPSASS protein degradation transcription, altered 19946213 2 9 0 +MRE11 MRE11A Cell cycle regulation; DNA repair, damage; DNA-binding; Deoxyribonuclease P49959 4361 11q21 human R592-me 2344810 ASRGGSQrGRADTGL intracellular localization 15970667 1 0 0 localizes in nucleus and associates with nuclear bodies and sites of DNA damage +KDM1A LSD1 DEMETHYLASE; Demethylase; EC 1.-.-.-; Nuclear receptor co-regulator; Oxidoreductase; Transcription factor O60341 23028 1p36.12 human K226-ub 1881258601 QLWLDNPkIQLTFEA protein degradation; molecular association, regulation carcinogenesis, induced; transcription, altered RCOR1(DISRUPTS); CDC6(INDUCES) 34050636 1 1 0 disrupts LSD1 association from RCOR1/HDACs complex +XRCC5 Ku80 DNA-binding; EC 3.6.1.-; EC 3.6.4.-; Helicase; Nuclear receptor co-regulator; Nucleolus; RNA-binding P13010 7520 2q35 human K525-ub 12348116 PPAEVTTkSQIPLSK Ku_C molecular association, regulation DNA repair, induced DNA(DISRUPTS) 27895153 1 4 5 +Map2 MAP2 iso3 Cytoskeletal; Motility/polarity/chemotaxis P15146-3 25595 9q32 rat T259-p 450181 YSSRTPGtPGTPSYP cytoskeletal reorganization 10826493 3 21 7 caused decrease in microtubule bundles +GPHN gephyrin Adaptor/scaffold; EC 2.10.1.1; EC 2.7.7.75 Q9NQX3 10243 14q23.3-q24.1 human C284-pa 34668144 SRLSTAScPTPKVQS molecular association, regulation; intracellular localization 25025157 1 1 0 clustering in neurons +H4C1 H4 DNA-binding P62805 8359 6p22.2 human K20-m1 1458623 GGAKRHRkVLRDNIQ CENP-T_C molecular association, regulation; acetylation; intracellular localization cell cycle regulation; DNA repair, induced; transcription, induced LUZP5(INDUCES); 53BP1(DISRUPTS); MBTD1(INDUCES); NCAPD3(INDUCES); JMJD2A(INDUCES) DNA(INDUCES) 17967882; 18470998; 19706462; 20622854; 20657587; 27153538; 33398850; 33710666 30 15 7 increased lipid accumulation, activity of KMT5A and K20 methylation, in human and in rat placenta; RNF8 recruits KMT5A to sites of DNA damage and cell survival with increase in H4K20 mono-methylation. ; MBTD1 can displace 53BP1 from the H4K20me2 histone mark +FNIP1 FNIP1 Q8TF40 96459 5q31.1 human S948-p 4734337 SALGDSEsEDTGHDM protein stabilization; molecular association, regulation signaling pathway regulation HSP90A(INDUCES) DNA(INDUCES) 30699359 1 3 0 +NDE1 NUDE1 iso1 Cell cycle regulation; Cytoskeletal; Microtubule-binding Q9NXR1-1 54820 16p13.11 human T246-p 467025 STGGTPLtPAARISA NUDE_C molecular association, regulation; intracellular localization cell cycle regulation ZNF365(DISRUPTS) 16682949; 21529751 2 14 31 +RCAN1 RCAN1 Inhibitor P53805 1827 21q22.12 human S163-p 456022 PDKQFLIsPPASPPV Calcipressin activity, induced; protein degradation transcription, altered 12809556; 16126726 7 34 5 increases calcineurin-inhibiting activity of DSCR1; Phosphorylation of MCIP at S108/S112 by MEKK3 is required for activation of calcineurin/NFAT signaling. +PELI1 PELI1 Adaptor/scaffold; EC 6.3.2.-; EC 6.3.2.19; Ligase; UBIQUITIN LIGASE; Ubiquitin conjugating system; Ubiquitin ligase Q96FA3 57162 2p14 human S82-p 7388012 HSISYTLsRAQTVVV Pellino ubiquitination; enzymatic activity, induced 19264966 2 0 0 +Ass1 ASS1 Amino Acid Metabolism - alanine, aspartate and glutamate; Amino Acid Metabolism - arginine and proline; EC 6.3.4.5; Endoplasmic reticulum; Ligase; Mitochondrial P16460 11898 2 B|2 21.81 cM mouse Y87-p 4273690 SALYEDRyLLGTSLA Arginosuc_synth enzymatic activity, induced transcription, induced; signaling pathway regulation 35016033 1 3 1 regulates JAK2-STAT1 signaling +ELF1 Elf-1 DNA-binding; Transcription factor P32519 1997 13q14.11 human T231-p 4825111 CPKYIKWtQREKGIF Ets transcription, altered 18714041 1 1 0 +HOXB7 HOXB7 DNA-binding; Motility/polarity/chemotaxis; Transcription factor P09629 3217 17q21.32 human S132-p 465569 RIYPWMRsSGTDRKR cell differentiation, altered 11290787 1 0 0 +Optn optineurin Inhibitor Q8K3K8 71648 2 A1|2 3.15 cM mouse S187-p 4762451 SGGSSEDsFVEIRMT autophagy, induced 33931895 10 30 1 regulates mitochondrial homeostasis and pluripotency +RUNX2 AML3 DNA-binding; Transcription factor Q13950 860 6p21.1 human S347-p 7386100 SDDDTATsDFCLWPS cell differentiation, inhibited; transcription, inhibited; transcription, altered 19264160; 30910359 2 2 0 in C2C12 cells +MKNK2 Mnk2 EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, CAMK; Protein kinase, Ser/Thr (non-receptor); Translation Q9HBH9 2872 19p13.3 human S437-p 456330 TSRCLQLsPPSQSKL activity, induced 23831578 2 10 3 +Ccdc88a girdin Actin-binding Q5SNZ0 108686 11|11 A3.3 mouse Y1801-p 450762 QSKDSNPyATLPRAS intracellular localization apoptosis, inhibited 28375676 5 13 137 +PXN PXN Adaptor/scaffold; Cell adhesion; Cytoskeletal; Motility/polarity/chemotaxis P49024 395832 chicken S481-p 448767 FTPFINGsFFEHDGQ LIM intracellular localization cell adhesion, altered 9658172 1 0 0 +NKX3-1 NKX3-1 DNA-binding; Transcription factor; Tumor suppressor Q99801 4824 8p21.2 human S185-p 4825101 KTKRKQLsSELGDLE protein degradation; protein stabilization; ubiquitination carcinogenesis, induced; cell growth, induced 18757402; 23129228; 25777618; 31213464 5 3 0 +TP63 p63 DNA-binding; Transcription factor Q9H3D4 8626 3q28 human T491-p 4668106 PQQRNALtPTTIPDG protein degradation DNA repair, induced; apoptosis, induced; transcription, inhibited 18769144; 19282665; 21602882 3 1 0 +DAB1 DAB1 Adaptor/scaffold Q8JH94 374083 chicken Y200-p 447960 VEDPVYQyIVFEAGH phosphorylation cytoskeletal reorganization 15057276 5 0 0 increases Src activation and overall tyrosine phosphorylation levels in the cell, alters cellular morphology +ELK1 ELK1 DNA-binding; Transcription factor P19419 2002 Xp11.23 human K254-sm 3982501 EVKVEGPkEELEVAG sumoylation; intracellular localization cell differentiation, inhibited; transcription, induced 15210726; 30789974 3 1 0 Both ELK1 and ELK-3R promote transcription, K230R, K249R, K254R does not prevent ELK1 SUMOylation, ELK1 and ELK1-3R show same intracellular localization ; regulates kinetics of nuclear export +HAT1 HAT1 ACETYLTRANSFERASE; Acetyltransferase; EC 2.3.1.48 O14929 8520 2q31.1 human S190-p 63080404 MWFIETAsFIDVDDE activity, induced; molecular association, regulation RBBP7(INDUCES) 28143904 1 0 0 +FLCN FLCN Tumor suppressor Q8NFG4 201163 17p11.2 human S73-p 3206877 GASVESSsPGPKKSD protein degradation; intracellular localization; activity, inhibited; phosphorylation cell cycle regulation; carcinogenesis, induced; signaling pathway regulation 23874397; 31395606 2 13 3 induces localization of mTORC1, increases phosphorylation of mTORC1 targets, regulates mTORC1 pathway +Wnk4 WNK4 EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, Other; Protein kinase, Ser/Thr (non-receptor) Q80UE6 69847 11|11 D mouse K447-ub 40323315 AEEDDGEkPGLKLWL protein degradation 23576762 1 1 0 regulates electrolyte homeostasis and involved in Pseudohypoaldosteronism type II (PHAII) pathogenesis +FUS hnRNP P2 DNA-binding; Nuclear receptor co-regulator; Oncoprotein; RNA splicing; RNA-binding; SUMO LIGASE P35637 2521 16p11.2 human S273-p 23113764 GGPRDQGsRHDSEQD molecular association, regulation hnRNP P2(DISRUPTS) 35753345 1 2 1 +NCOA2 SRC-2 Motility/polarity/chemotaxis; Nuclear receptor co-regulator; Transcription, coactivator/corepressor Q15596 10499 8q13.3 human S736-p 465446 TIKQEPVsPKKKENA DUF4927 transcription, induced 11301320 4 20 10 important for EGF-induced transcriptional activation +CREB1 CREB DNA-binding; Transcription factor P16220 1385 2q33.3 human K290-sm 12063904 ARECRRKkKEYVKCL bZIP_1 protein stabilization; intracellular localization transcription, induced 12552083 2 0 0 +Atf2 ATF-2 ACETYLTRANSFERASE; C2H2-type zinc finger protein; EC 2.3.1.48; Transcription factor P16951 11909 2|2 C3 mouse T51-p 448224 SVIVADQtPTPTRFL protein stabilization carcinogenesis, induced; cell growth, induced; transcription, altered 10521481; 21706057 32 57 50 +ANXA2 ANXA2 Calcium-binding; Lipid-binding; Motility/polarity/chemotaxis P04272 282689 cow S26-p 450879 TPPSAYGsVKAYTNF sumoylation; molecular association, regulation; ubiquitination; intracellular localization; protein conformation ACTG1(INDUCES); ACTB(INDUCES) RNA(INDUCES) 24780253; 28174683 14 29 100 +SOCS1 SOCS1 Inhibitor; UBIQUITIN LIGASE O15524 8651 16p13.13 human Y80-p 1868450203 LLDACGFyWGPLSVH SH2 molecular association, regulation; intracellular localization; activity, inhibited carcinogenesis, induced; signaling pathway regulation SOCS1(INDUCES); p53(DISRUPTS) 31101761 1 1 0 inactivates SOCS1-p53 senescence pathway; inhibits SOCS1 tumor suppressor activity; induces dimers formation +Shtn1 SHOT1 Unknown function Q8K2Q9 71653 19|19 D2-D3 mouse S101-p 4761847 NKTLKRIsMLYMAKL molecular association, regulation neural plasticity; cell adhesion, induced; cytoskeletal reorganization CDH2(INDUCES); Cortactin(INDUCES); NCAM-L1(INDUCES) 34010643 4 5 0 +STK11 LKB1 Autophagy; EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, CAMK; Protein kinase, Ser/Thr (non-receptor); Tumor suppressor Q15831 6794 19p13.3 human T189-p 448149 LLLTTGGtLKISDLG Pkinase apoptosis, inhibited 11430832 2 0 0 +HAX1 HAX1 Apoptosis; Endoplasmic reticulum; Mitochondrial; Vesicle O00165 10456 1q21.3 human S210-p 37043700 QPKSYFKsISVTKIT protein degradation; molecular association, regulation; ubiquitination apoptosis, induced FBXO25(INDUCES) 25419709 1 0 0 +INSIG1 INSIG1 Membrane protein, integral; Membrane protein, multi-pass O15503 3638 7q36.3 human T222-p 1868139204 ITIAFLAtLITQFLV INSIG; TM activity, induced; protein stabilization; molecular association, regulation AMFR(DISRUPTS) 30733434 1 1 0 inhibits SREBP-1c cleavage processing and lipogenic gene expression +PPP1R16B PPP1R16B Motility/polarity/chemotaxis; Protein phosphatase, regulatory subunit Q95N27 282091 cow S333-p 486244 LRHKSSLsRRTSSAG cytoskeletal reorganization 17609201 2 1 0 +Grin1 NMDAR1 Channel, calcium; Channel, ligand-gated; Membrane protein, integral; Membrane protein, multi-pass P35439 24408 3p13 rat S890-p 447737 ITSTLASsFKRRRSS molecular association, regulation; intracellular localization; activity, inhibited Calmodulin(DISRUPTS) 21163614; 9030583; 9252405 12 2 3 +SLC3A2 SLC3A2 Membrane protein, integral; Transporter P08195 6520 11q12.3 human S531-p 6003501 RRLSDQRsKERSLLH cell adhesion, altered 19065266 1 0 0 enhances cell- cell interactions +Oprm1 MOR-1 GPCR, family 1; Membrane protein, integral; Membrane protein, multi-pass; Receptor, GPCR P33535 25601 1q11 rat S375-p 447784 QNTREHPsTANTVDR molecular association, regulation; receptor desensitization, altered; receptor internalization, altered; protein conformation ARR3(INDUCES); ARRB2(INDUCES) 11278523; 12860981; 15272312; 15890842; 18558479; 23106126 24 5 0 +Zfpm2 FOG2 C2H2-type zinc finger protein; Nuclear receptor co-regulator Q8CCH7 22762 15 B3.1|15 15.74 cM mouse K471-sm 1873213001 NFSYTKIkSEPSSPR molecular association, regulation transcription, induced GATA4(DISRUPTS) 23226341 1 0 0 desumoylation induces repression +SYK Syk EC 2.7.10.2; KINASE; Kinase, protein; Protein kinase, TK; Protein kinase, tyrosine (non-receptor) P43405 6850 9q22.2 human S178-p 25687503 GKISREEsEQIVLIG SH2 cell adhesion, induced; signaling pathway regulation 22848421 1 0 0 PKC-LKB1-AMPK signaling pathway to induce cell adhesion +Parp1 PARP1 iso3 DNA repair, damage; EC 2.4.2.30; Nuclear envelope; Nuclear receptor co-regulator; Nucleolus; Transferase Q3TF18 11545 1 H4|1 84.44 cM mouse Y829-p 1869121001 HATTHNAyDLEVIDI PARP activity, induced transcription, induced; signaling pathway regulation 31399520 1 0 0 regulates LPS-induced inflammation; PARP1-NFKB pathway regulation +E2F4 E2F4 DNA-binding Q16254 1874 16q22.1 human S244-p 28843800 QEASRPNsPQLTPTA intracellular localization cell cycle regulation; transcription, induced 23919615 1 1 0 +MFN1 MFN1 EC 3.6.5.-; Hydrolase; Membrane protein, integral; Membrane protein, multi-pass; Mitochondrial Q8IWA4 55669 3q26.33 human S86-p 1498941800 AFFGRTSsGKSSVIN Dynamin_N enzymatic activity, inhibited apoptosis, induced 30659190 1 1 0 +CNN1 calponin 1 Actin-binding; Contractile; Motility/polarity/chemotaxis; Myosin-binding P26932 396522 chicken T180-p 469594 FASQQGMtAYGTRRH Calponin molecular association, regulation ACTA1(DISRUPTS) 10873572 1 0 1 f-actin (rabbit skeletal muscle) shown by co-sedimentation +NEDD8 NEDD8 Ubiquitin-like modifier Q15843 4738 14q12 human S65-p 4705608 DYKILGGsVLHLVLA ubiquitin molecular association, regulation; protein conformation PARK2(INDUCES); HSP70(INDUCES) 34642328 1 5 1 induces phosphorylation, activation and autoubiquitylation of Parkin +CBX3 CBX3 DNA-binding Q13185 11335 7p15.2 human S93-p 457001 KDGTKRKsLSDSESD molecular association, regulation; intracellular localization chromatin organization, altered; transcription, induced; signaling pathway regulation Ku70(NOT_REPORTED) 16531993; 17242207; 25216677 5 57 61 MAPK pathway +PDE5A PDE5A EC 3.1.4.35; Nucleotide Metabolism - purine; Phosphodiesterase O76074 8654 4q26 human S102-p 448178 GTPTRKIsASEFDRP molecular association, regulation; enzymatic activity, inhibited; protein conformation; enzymatic activity, induced Other(INDUCES) 16690614; 25247292 8 6 0 +Rho Rhodopsin GPCR, family 1; Membrane protein, integral; Membrane protein, multi-pass; Receptor, GPCR P15409 212541 6 E3|6 53.72 cM mouse S338-p 448679 DDASATAsKTETSQV receptor inactivation, altered 11086991 8 7 0 Mutant rhodopsins had prolonged rate of recovery with increasing number of phosphorylation sites. +RPS6KB1 p70S6K iso2 EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, AGC; Protein kinase, Ser/Thr (non-receptor); Translation P23443-2 6198 17q23.1 human K493-ac 14790001 QAFPMISkRPEHLRM molecular association, regulation; enzymatic activity, inhibited; phosphorylation transcription, inhibited Raptor(DISRUPTS) 24652283; 31028173 4 1 0 inhibits mesangial cell hypertrophy and expression of fibronectin and collagen I ; Sirt1,2 deacetylate p70S6K which enhances T389 phosphorylation and it's kinase activity +AMOT AMOT Q4VCS5 154796 Xq23 human K496-ub 41481888 LEKAMRNkLEGEIRR protein degradation 27462448 1 3 0 +TFEB TFEB DNA-binding; Transcription factor P19484 7942 6p21.1 human S142-p 3181628 AGNSAPNsPMAMLHI MITF_TFEB_C_3_N protein degradation; molecular association, regulation; ubiquitination; intracellular localization; activity, inhibited carcinogenesis, induced; autophagy, inhibited; transcription, inhibited Exportin-1(INDUCES); CHIP(INDUCES) 28754656; 32662822; 33753903; 34611296; 36970883 13 12 0 +STXBP2 STXBP2 Q15833 6813 19p13.2 human T572-p 487544 IGSSHILtPTRFLDD Sec1 molecular association, regulation; protein conformation exocytosis, induced STX3(DISRUPTS); SNAP-25(INDUCES) 17716669 1 0 0 in vitro +NHE-3 NHE3 Membrane protein, integral; Membrane protein, multi-pass; Transporter; Transporter, SLC family P26432 100009430 rabbit S515-p 31839901 NFDRRFLsKLLMRQS activity, induced; molecular association, regulation; intracellular localization Ezrin(INDUCES) 24398676 1 0 0 +BLM BLM DNA repair, damage; DNA replication; EC 3.6.4.12; Helicase P54132 641 15q26.1 human S338-p 4700251 KEDVLSTsKDLLSKP BLM_N protein stabilization; molecular association, regulation cell cycle regulation; DNA repair, altered TOPBP1(DISRUPTS) 24239288 2 7 0 +PLN PLB Inhibitor; Membrane protein, integral P61015 rabbit T17-p 448115 SAIRRAStIEMPQQA Phospholamban activity, induced 21555709 75 12 63 induces SERCA2 activity +SP1 SP1 C2H2-type zinc finger protein; DNA-binding; Transcription factor P08047 6667 12q13.13 human S728-p 2535904 VGTLPLDsGAGSEGS protein degradation; molecular association, regulation; ubiquitination signaling pathway regulation BTRC(INDUCES) 18239466; 19372209; 30181396 3 0 0 also inhibits stabilization of B-Catennin thus regulating Wnt signaling +IRF5 IRF5 DNA-binding; Transcription factor Q13568 3663 7q32.1 human S446-p 26389901 DSIRLQIsNPDLKDR protein stabilization; molecular association, regulation; intracellular localization apoptosis, induced; transcription, induced CBP(INDUCES) 18836453; 22412986; 25326418 3 2 0 +Gad2 GAD2 Amino Acid Metabolism - alanine, aspartate and glutamate; Carbohydrate Metabolism - butanoate; EC 4.1.1.15; Lyase; Other Amino Acids Metabolism - beta-alanine; Other Amino Acids Metabolism - taurine and hypotaurine Q05683 24380 17q12.3 rat T95-p 53356800 NYALLHAtDLLPACE activity, induced 26780456 1 1 0 +Mapk7 ERK5 EC 2.7.11.24; KINASE; Kinase, protein; Protein kinase, CMGC; Protein kinase, Ser/Thr (non-receptor) Q9WVS8 23939 11|11 B2 mouse T723-p 455520 LPPVFSGtPKGSGAG transcription, altered 17928297 7 13 1 +F2RL1 F2RL1 GPCR, family 1; Membrane protein, integral; Membrane protein, multi-pass; Receptor, GPCR P55085 2150 5q13.3 human S385-p 12184119 KHSRKSSsYSSSSTT receptor desensitization, induced; molecular association, regulation; phosphorylation signaling pathway regulation ARRB1(INDUCES); ARRB2(INDUCES) 33073187 1 1 1 inhibits ERK phosphorylation and signaling; regulates calcium signaling +Vasp VASP Cytoskeletal; Motility/polarity/chemotaxis B5DEX4 361517 1q21 rat S236-p 448380 GAKLRKVsKEEASGG cell adhesion, inhibited; signaling pathway regulation 33772737; 34475824 62 26 3 +NFATC4 NFAT3 DNA-binding; Transcription factor Q14934 4776 14q12 human S676-p 455348 SNGRRKRsPTQSFRF RHD_dimer activity, induced transcription, induced 15657420 2 0 0 +GTF2F1 GTF2F1 EC 2.7.11.1; KINASE; Kinase, protein; Transcription initiation complex P35269 2962 19p13.3 human T389-p 483595 RGNSRPGtPSAEGGS TFIIF_alpha activity, inhibited transcription, inhibited 10428810 1 54 270 slows down RNA pol II elongation +PTPN6 SHP-1 EC 3.1.3.48; Motility/polarity/chemotaxis; PHOSPHATASE; Protein phosphatase, tyrosine (non-receptor) P29350 5777 12p13.31 human Y276-p 15428268 ENKGKNRyKNILPFD Y_phosphatase molecular association, regulation transcription, inhibited; signaling pathway regulation GRB2(INDUCES) 14551136 1 3 50 recruitment of Grb2 targets SOCS-1 to Jak2 +Sirt7 SIRT7 DEACETYLASE; Deacetylase; EC 3.5.1.-; Nucleolus Q8BKJ9 209011 11|11 E2 mouse S260-p 1874512904 EAATEAAsKADTILC SIR2 protein stabilization; molecular association, regulation; ubiquitination; phosphorylation carcinogenesis, inhibited; cell motility, inhibited; transcription, inhibited; signaling pathway regulation UBR5(DISRUPTS); SKP2(INDUCES) 34433808 1 0 0 inhibits ubiquitination of itself, inhibits AKT phosphorylation and PI3K/AKT pathway +GRB7 GRB7 Adaptor/scaffold; Motility/polarity/chemotaxis Q14451 2886 17q12 human Y338-p 7965101 AAFRLFKyGVQLYKN PH phosphorylation cell cycle regulation; cell motility, altered 19473962 1 0 0 double mutation Grb7 Y188, 338F inhibits phosphorylation of FAK Y397 (Y428 in mouse), Y861 (Y899 in mouse) and PXN Y118; involed in tumorigenesis process +Pml PML Nucleolus; Oncoprotein; SUMO LIGASE; SUMO conjugating system; SUMO ligase; Transcription factor; Tumor suppressor; Ubiquitin conjugating system Q60953 18854 9 B|9 31.63 cM mouse K497-ac 4659502 SHEDCSRkIIKMEST DUF3583 intracellular localization transcription, induced 22274616 2 0 1 regulates PER2 nuclear localization and increases BMAL1/CLOCK transcription activity +Cdh1 CDH1 Cell adhesion; Membrane protein, integral; Motility/polarity/chemotaxis; UBIQUITIN LIGASE; Ubiquitin ligase P09803 12550 8 D3|8 53.18 cM mouse Y756-p 456025 DTRDNVYyYDEEGGG molecular association, regulation CBLL1(INDUCES) 11836526 3 2 44 +NFKB1 NFkB-p105 DNA-binding; Transcription factor P19838 4790 4q24 human S927-p 447770 DSDSVCDsGVETSFR protein degradation; ubiquitination; protein processing 10469655; 11158290; 11297557; 11976329; 12482991; 19250910 6 0 2 Ubiquitination does not require generation of polyubiquitin chains, S927A mutant can be ubiquinated and processed to p50 in vitro and can only be processed constitutively in a basal manner. +MRPL10 MRPL10 Mitochondrial; Ribosomal; Translation Q3MHY7 515014 cow K162-ac 12674401 VSEEPKVkEMVRILK Ribosomal_L10 translation, induced 20042612 1 1 0 downregulates protein synthesis +Neurog3 neurogenin 3 Cell development/differentiation; DNA-binding; Transcription factor P70661 11925 10|10 B4 mouse S183-p 35527103 VSQAGNLsPTASLEE protein degradation; molecular association, regulation; ubiquitination FBXW7(INDUCES) 25105579 2 0 0 +NFE2L2 NRF2 DNA-binding; Transcription factor Q16236 4780 2q31.2 human K538-ac 7106320 HLKDEKEkLLKEKGE bZIP_Maf molecular association, regulation transcription, induced DNA(INDUCES) 19273602 1 1 0 +RPTOR Raptor Adaptor/scaffold Q8N122 57521 17q25.3 human S855-p 3205935 QRVLDTSsLTQSAPA molecular association, regulation signaling pathway regulation 4E-BP1(DISRUPTS) 21460630 2 4 0 mTORC1 signaling +VASP VASP Cytoskeletal; Motility/polarity/chemotaxis P50552 7408 19q13.32 human S239-p 448380 GAKLRKVsKQEEASG molecular association, regulation; intracellular localization; activity, inhibited; enzymatic activity, induced carcinogenesis, inhibited; cell motility, altered; cell motility, inhibited; cell adhesion, altered; cytoskeletal reorganization; transcription, inhibited; cell growth, altered MYO1C(DISRUPTS); ACTR3B(DISRUPTS); MYO5A(DISRUPTS); Arp3(DISRUPTS); MYO1B(DISRUPTS); ARP2(DISRUPTS); ACTG1(DISRUPTS) 14679200; 15178555; 17684063; 18637808; 19798690; 20463151; 20483741; 32209483; 37019383; 37335130 62 26 3 +NUP98 NUP98 iso2 Motility/polarity/chemotaxis; Nucleoporin P52948-2 4928 11p15.4 human S664-p 14577176 AGNKHSNsNSVDDTI intracellular localization 21335236 1 15 0 as multiple sites (13PM) mutant +HDAC1 HDAC1 DEACETYLASE; Deacetylase; EC 3.5.1.98; Hydrolase; Nuclear receptor co-regulator Q13547 3065 1p35.2-p35.1 human K432-ac 4219803 EEGEGGRkNSSNFKK enzymatic activity, inhibited transcription, inhibited 16762839 2 0 0 +Tp53 p53 Activator; DNA-binding; Motility/polarity/chemotaxis; Nuclear receptor co-regulator; Transcription factor; Tumor suppressor P02340 22059 11 B3|11 42.83 cM mouse K383-ub 464662 RHKKTMVkKVGPDSD transcription, altered 15964796 10 0 1 p53K6R (K378/383/369/379/367/370/R) mutant is still ubiquitinated and shows normal stability of p53 before and after DNA damage +GJA1 GJA1 Channel, misc.; Membrane protein, integral; Membrane protein, multi-pass; Motility/polarity/chemotaxis P17302 2697 6q22.31 human S330-p 449994 AGSTISNsHAQPFDF Connexin43 protein conformation 23828237 10 14 0 +MAP3K5 ASK1 EC 2.7.11.25; KINASE; Kinase, protein; Protein kinase, STE; Protein kinase, Ser/Thr (non-receptor) Q99683 4217 6q23.3 human K1083-sm 12004431 GAEEPKLkWEHITTL HisK-N-like molecular association, regulation apoptosis, inhibited ASK1(DISRUPTS); SUMO1(INDUCES) 16142216 1 0 0 ASK1 is not sumoylated but SUMO1 interaction inhibits the oligomerization of ASK1 +Tdg TDG DNA repair, damage; EC 3.2.2.29; Hydrolase; Nuclear receptor co-regulator P56581 21665 10 C1|10 39.72 cM mouse K341-sm 3144814 DAKKMAVkEEKYDPG molecular association, regulation; intracellular localization CBP(DISRUPTS) 17060459 5 3 0 negatively regulates POD translocation ; blocks interaction with CBP preventing TDG acetylation +SLC4A4 SLC4A4 Membrane protein, integral; Membrane protein, multi-pass; Transporter; Transporter, SLC family Q9Y6R1 8671 4q13.3 human S65-p 4699735 ERISENYsDKSDIEN intracellular localization 23431199 2 18 0 reduction of surface expression; inhibition by STLK3 +Lats1 LATS1 EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, AGC; Protein kinase, Ser/Thr (non-receptor); Tumor suppressor Q8BYR2 16798 10|10 A1 mouse S908-p 457594 HQRCLAHsLVGTPNY Pkinase intracellular localization; phosphorylation; enzymatic activity, induced cell growth, inhibited; transcription, induced; signaling pathway regulation 35394840 32 5 15 +Cad CAD Amino Acid Metabolism - alanine, aspartate and glutamate; EC 2.1.3.2; EC 3.5.2.3; EC 6.3.5.5; Hydrolase; KINASE; Ligase; Nucleotide Metabolism - pyrimidine; Transferase P08955 101843763 hamster T1037-p 2861417 QQCRVLGtSPEAIDS enzymatic activity, induced 11986331 1 0 0 +ALDH2 ALDH2 Amino Acid Metabolism - arginine and proline; Amino Acid Metabolism - histidine; Amino Acid Metabolism - lysine degradation; Amino Acid Metabolism - tryptophan; Amino Acid Metabolism - valine, leucine and isoleucine degradation; Carbohydrate Metabolism - ascorbate and aldarate; Carbohydrate Metabolism - butanoate; Carbohydrate Metabolism - glycolysis and gluconeogenesis; Carbohydrate Metabolism - propanoate; Carbohydrate Metabolism - pyruvate; EC 1.2.1.3; Lipid Metabolism - fatty acid; Lipid Metabolism - glycerolipid; Mitochondrial; Other Amino Acids Metabolism - beta-alanine; Oxidoreductase; Secondary Metabolites Metabolism - limonene and pinene degradation P05091 217 12q24.12 human T356-p 1273608200 GNPFDSKtEQGPQVD Aldedh intracellular localization transcription, inhibited 30375985 0 1 0 nuclear localization , ATP6V0E2 transcription decreased, regulates foam cell formation +EIF2AK2 PKR EC 2.7.10.2; EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, Other; Protein kinase, Ser/Thr (non-receptor); Protein kinase, tyrosine (non-receptor); Translation P19525 5610 2p22.2 human S6-p 23132463 __MAGDLsAGFFMEE molecular association, regulation; enzymatic activity, inhibited; protein conformation; phosphorylation apoptosis, inhibited PKR(INDUCES) RNA(INDUCES) 33911136 1 1 1 inhibits phosphorylation at other sites and of elF2 +SUPT5H SPT5 RNA-binding; Transcription, coactivator/corepressor O00267 6829 19q13.2 human T814-p 458820 PLHDGSRtPAQSGAW transcription, altered 16427012 1 1 7 required for c-fos induction and activation in vivo +TTK TTK Cancer Testis Antigen (CTA); EC 2.7.12.1; KINASE; Kinase, protein; Protein kinase, Other; Protein kinase, dual-specificity (non-receptor) P33981 7272 6q14.1 human S214-p 14161585 TVLTAQEsFSGSLGH intracellular localization; enzymatic activity, induced 26119734 1 2 2 regulates spindle assembly checkpoint and recruitment of SAC proteins +H2ax H2AX DNA repair, damage; DNA-binding; Helicase D3ZXP3 500987 8q22 rat S139-p 448841 GKKASQAsQEY____ DNA repair, induced 33737606 289 32 29 +Bmf BMF Apoptosis; Cytoskeletal Q91ZE9 171543 2|2 E5 mouse T72-p 1874396402 QEDKATQtLSPASPS BMF molecular association, regulation; intracellular localization apoptosis, induced STARD13(DISRUPTS) 34462553 1 0 0 +GALNT2 GALNT2 EC 2.4.1.41; Glycan Metabolism - O-glycan biosynthesis; Membrane protein, integral; Transferase Q10471 2590 1q42.13 human K521-ac 25336507 RENDSRQkWEQIEGN Ricin_B_lectin molecular association, regulation; O-GalNAc glycosylation; protein conformation MUC1(DISRUPTS); MUC2(DISRUPTS) Other(INDUCES) 21651894; 23096348 1 1 0 induces binding to glycan; enhances carbohydrate specificity, decreases glycosylation +ACBD4 ACBD4 Lipid-binding Q8NC06 79777 17q21.31 human S171-p 34506016 PPSPESHsPRDLDSE molecular association, regulation VAPB(INDUCES) 35019937 1 2 0 +PTBP2 PTBP2 RNA processing; RNA-binding Q9UKA9 58155 1p21.3 human K137-sm 31089521 YSNHKELkTDNTLNQ intracellular localization 24286314 1 0 0 Decreased sumoylation causes export to cytoplasm in glioma cells. +Rela NFkB-p65 DNA-binding; Nuclear receptor co-regulator; Transcription factor Q7TQN4 309165 1q43 rat R30-m2 1881937800 IIEQPKQrGMRFRYK cell adhesion, induced; transcription, induced 35379776 1 0 0 VCAM-1 expression in VSMC, H2O2 production in VSMC treated with TMAO, vascular in?ammation in vivo +PTGS2 COX-2 EC 1.14.99.1; Lipid Metabolism - arachidonic acid; Oxidoreductase P35354 5743 1q31.1 human S601-p 1869465800 TVLLKERsTEL____ protein degradation; molecular association, regulation; intracellular localization signaling pathway regulation NLRP3(DISRUPTS); DERL1(INDUCES) 31612242 1 0 0 +SOX6 SOX6 DNA-binding P35712 55553 11p15.2 human K404-sm 2407406 TVSPTGIkNEKRGTS intracellular localization transcription, inhibited 16442531 1 0 0 +Echs1 ECHS1 Amino Acid Metabolism - lysine degradation; Amino Acid Metabolism - tryptophan; Amino Acid Metabolism - valine, leucine and isoleucine degradation; Carbohydrate Metabolism - butanoate; Carbohydrate Metabolism - propanoate; EC 4.2.1.17; Lipid Metabolism - fatty acid; Lipid Metabolism - fatty acid elongation in mitochondria; Lyase; Mitochondrial; Other Amino Acids Metabolism - beta-alanine; Secondary Metabolites Metabolism - limonene and pinene degradation Q8BH95 93747 7|7 F4 mouse K101-ac 467120 FAAGADIkEMQNRTF ECH_1 protein degradation; ubiquitination; intracellular localization; enzymatic activity, inhibited carcinogenesis, induced; signaling pathway regulation 28878358 1 7 16 activates mTOR signaling +SCN8A SCN8A Channel, sodium; Membrane protein, integral; Membrane protein, multi-pass Q9UQD0 6334 12q13.13 human T642-p 1869659201 RSVKRNStVDCNGVV Na_trans_cytopl activity, induced; activity, inhibited neural plasticity 32611770; 35805192 2 1 0 Regulates voltage-gated sodium channel Nav1.6 activity and neuronal excitability +Mapt Tau ACETYLTRANSFERASE; Acetyltransferase; Cytoskeletal P19332 29477 10q32.1 rat S707-p 449081 GAEIVYKsPVVSGDT neural plasticity 33519375; 33797746 192 49 90 +SF1 SF1 RNA splicing; RNA-binding; Spliceosome; Transcription, coactivator/corepressor Q15637 7536 11q13.1 human S80-p 452434 PPNPEDRsPSPEPIY SF1-HH molecular association, regulation RNA splicing, altered U2AF2(INDUCES) 16420481 1 91 12 facilitates formation of the SF1-U2AF-RNA complex +KRT5 K5 Cytoskeletal P13647 3852 12q13.13 human T151-p 288031706 TVNQSLLtPLNLQID Keratin_2_head molecular association, regulation cytoskeletal reorganization HSP70(INDUCES) 29080682 2 1 0 phosphomimetic T150 K5 mutation prevents keratin network formation in the absence of wildtype keratins; impairs keratin filament network assembly and, conversely, favors disassembly of keratin filaments ; keratin filament (KF) network +XRCC1 XRCC1 DNA repair, damage P18887 7515 19q13.31 human T488-p 451452 GAEDSGDtEDELRRV molecular association, regulation; intracellular localization PARP1(DISRUPTS); Pnk1(INDUCES) 15066279; 25477519 4 16 0 +INSIG1 INSIG1 Membrane protein, integral; Membrane protein, multi-pass O15503 3638 7q36.3 human K158-ub 486339 LGEPHKFkREWASVM INSIG protein degradation 16399501; 16549805 2 0 0 INSIG1 is degraded more rapidly than INSIG2 which controlled by serine residues flanking the ubiquitination sites in both proteins. +Smpd3 SMPD3 EC 3.1.4.12; Lipid Metabolism - sphingolipid; Membrane protein, integral; Phospholipase Q9JJY3 58994 8|8 D3 mouse S299-p 9430287 SPSASREsLVKARAG protein stabilization; enzymatic activity, induced 22074919 1 4 4 +OTUD3 OTUD3 DEUBIQUITINASE; EC 3.4.19.12 Q5T2D3 23252 1p36.13 human K129-ac 1875273800 KHVASLAkPGTFAGN OTU enzymatic activity, induced 32679077; 35675783 2 1 0 +Irs2 IRS2 Adaptor/scaffold; Motility/polarity/chemotaxis P81122 384783 8 A1.1|8 5.35 cM mouse Y649-p 454969 NLGADDGyMPMTPGA molecular association, regulation; phosphorylation signaling pathway regulation PIK3R1(INDUCES) 24811175 1 27 520 promotes GSK3B phosphorylation, regulates aerobic glycolysis +Arhgef15 ephexin-5 GEF; GEF, Rac/Rho Q5FWH6 442801 11|11 B3 mouse S107-p 17546056 PSPVSRRsISPEPAP activity, induced cytoskeletal reorganization 30485813 1 1 0 Suppression of hippocampal dendritic spine formation; RhoA activation +Nrip1 RIP140 Nuclear receptor co-regulator; Transcription, coactivator/corepressor Q8CBD1 268903 16|16 C3.1 mouse S1003-p 455634 VTDHRTFsYPGMVKT NRIP1_repr_4 molecular association, regulation; methylation; intracellular localization transcription, altered 14-3-3 beta(INDUCES); PRMT1(INDUCES) 18628823 1 5 0 regulates fat accumulation +Irs1 IRS1 Adaptor/scaffold; Motility/polarity/chemotaxis P35569 16367 1 C5|1 42.0 cM mouse S662-p 2352501 PNGYMMMsPSGSCSP molecular association, regulation PIK3C2A(DISRUPTS) 10092613 2 1 6 +TIRAP TIRAP Adaptor/scaffold P58753 114609 11q24.2 human T28-p 63052800 MADWFRQtLLKKPKK protein degradation; molecular association, regulation; ubiquitination; protein conformation 28225045 1 0 0 Reduced phosphoinositide (PI) binding +Cebpa C/EBP-alpha DNA-binding; Transcription factor P05554 24252 1q21 rat S248-p 449826 GLPGPGGsLKGLAGP activity, induced cell differentiation, altered; transcription, inhibited; cell growth, altered 11978795; 18302931; 26153766 4 0 0 +LIN37 F25965 Q96GY3 55957 19q13.12 human S182-p 453530 ACRSRIPsPLQPEMQ LIN37 molecular association, regulation LIN52(INDUCES) 21498570 1 22 13 +TRPV4 TRPV4 Channel, cation; Membrane protein, integral; Membrane protein, multi-pass Q9HBA0 59341 12q24.11 human S162-p 10272403 FDIVSRGsTADLDGL activity, induced 19661060 1 1 0 +RET Ret EC 2.7.10.1; KINASE; Kinase, protein; Membrane protein, integral; Oncoprotein; Protein kinase, TK; Protein kinase, tyrosine (receptor) P07949 5979 10q11.21 human Y928-p 3078002 ESLFDHIyTTQSDVW PK_Tyr_Ser-Thr enzymatic activity, induced 11956105 2 1 0 +SKP2 SKP2 Cell cycle regulation; UBIQUITIN LIGASE; Ubiquitin conjugating system; Ubiquitin ligase Q13309 6502 5p13.2 human S72-p 480507 PPRKRLKsKGSDKDF activity, induced; protein stabilization; phosphorylation cell cycle regulation 20663873; 26636645 5 8 5 +WIZ WIZ C2H2-type zinc finger protein O95785 58525 19p13.12 human K967-m1 10414258 PAVNKAIkSPPGFSA molecular association, regulation L3MBTL iso4(INDUCES) 23583077 0 3 16 +EIF5A2 EIF5A2 Q9GZV4 56648 3q26.2 human K121-ub 964512656 LPEGELGkEIEGKYN eIF-5a protein degradation 35064108 1 2 0 regulate EMT, and may inhibit the metastasis of CRC +AKT1 Akt1 EC 2.7.11.1; KINASE; Kinase, protein; Oncoprotein; Protein kinase, AGC; Protein kinase, Ser/Thr (non-receptor) P31749 207 14q32.33 human T72-p 460648 TERPRPNtFIIRCLQ PH enzymatic activity, induced apoptosis, inhibited 16549426 2 0 1 doxorubicin-induced apoptosis +DYRK2 DYRK2 iso2 EC 2.7.12.1; KINASE; Kinase, protein; Protein kinase, CMGC; Protein kinase, dual-specificity (non-receptor) Q92630-2 8445 12q15 human Y309-p 454666 EHQRVYTyIQSRFYR Pkinase cell cycle regulation; apoptosis, induced 34363019 1 44 1649 +RELA NFkB-p65 DNA-binding; Nuclear receptor co-regulator; Transcription factor Q04206 5970 11q13.1 human K62-ub 25087014 TKTHPTIkINGYTGP RHD_DNA_bind protein degradation transcription, inhibited 23624912 2 1 0 +CDCA8 Borealin Cell cycle regulation; Nucleolus Q53HL2 55143 1p34.3 human T94-p 4203201 ATADLDItEINKLTA cell cycle regulation; cytoskeletal reorganization 18243099 2 0 0 chromosome alignment in mitosis +ENO1 ENO1 Carbohydrate Metabolism - glycolysis and gluconeogenesis; EC 4.2.1.11; Lyase; Transcription, coactivator/corepressor P06733 2023 1p36.23 human S419-p 7104866 RIEEELGsKAKFAGR Enolase_C cell growth, induced; signaling pathway regulation 26096821 2 33 0 +GLI3 GLI3 C2H2-type zinc finger protein; Transcription factor P10071 2737 7p14.1 human S1006-p 15501397 GHGVRRAsDPVRTGS protein processing transcription, inhibited 10693759 1 4 4 +PDE10A PDE10A iso2 EC 3.1.4.17; EC 3.1.4.35; Nucleotide Metabolism - purine; Phosphodiesterase Q9Y233-2 10846 6q27 human C11-pa 15169800 GPSNNAScFRRLTEC intracellular localization 20610737 1 0 0 +Sox11 SOX11 DNA-binding; Transcription factor Q7M6Y2 20666 12|12 A2 mouse S244-p 454322 SVAKVPAsPTLSSAA protein degradation cell differentiation, induced 34431536 1 3 0 +Ppp1r12a MYPT1 Motility/polarity/chemotaxis; PHOSPHATASE; Protein phosphatase, regulatory subunit Q9DBR7 17931 10 D1|10 56.33 cM mouse T694-p 448587 ARQSRRStQGVTLTD enzymatic activity, inhibited; phosphorylation 10601309; 37057180 66 42 226 induces MLC phosphorylation +H3C1 H3 DNA-binding P68431 8350 6p22.2 human K36-ac 466364 APATGGVkKPHRYRP Histone molecular association, regulation; intracellular localization chromatin organization, altered; transcription, induced polybromo 1(INDUCES) DNA(INDUCES); DNA(DISRUPTS) 17189264; 19884317; 20368734; 20720004 8 7 6 +PACS1 PACS-1 Adaptor/scaffold Q6VY07 55690 11q13.1-q13.2 human S278-p 2911721 SPDIDNYsEEEEESF activity, induced; molecular association, regulation TXN(DISRUPTS) 14633983 1 1 0 increases binding to HIV Nef protein +TRPM4 TRPM4 Membrane protein, integral; Membrane protein, multi-pass Q8TD43 54795 19q13.33 human S839-p 36400700 GLSGGGGsLASGGPG Ion_trans intracellular localization 25231975 1 1 0 basolateral localization +POU4F1 POU4F1 Cell development/differentiation; DNA-binding; Transcription factor Q01851 5457 13q31.1 human S121-p 6322100 GDLLDHIsSPSLALM activity, induced cell differentiation, induced; transcription, induced 16126301 1 0 0 +NR3C1 GR DNA-binding; Mitochondrial; Nuclear receptor; Transcription factor P04150 2908 5q31.3 human K277-sm 2532301 NVTLPQVkTEKEDFI GCR protein degradation transcription, induced; transcription, inhibited 12144530; 12193561 5 3 0 +Fxyd1 PLM Cell surface; Channel, misc.; Membrane protein, integral Q9Z239 56188 7|7 B1 mouse S83-p 451424 EEGTFRSsIRRLSSR intracellular localization 16371442 22 20 60 After stimulation with phorbol ester. +IKBKE IKKE EC 2.7.11.10; Inhibitor; KINASE; Kinase, protein; Protein kinase, Other; Protein kinase, Ser/Thr (non-receptor) Q14164 9641 1q32.1 human K401-ub 40323318 DPALDVPkFVPKVDL TBK1_CCD1 molecular association, regulation; phosphorylation; enzymatic activity, induced carcinogenesis, induced; cell growth, induced; transcription, induced IKKB(INDUCES); IKKG(INDUCES) 23453969 1 2 0 regulates NF-kB pathway activation- TLR signaling, enhanced CYLD phosphorylation +SREBF1 SREBP-1 iso3 DNA-binding; Membrane protein, integral; Membrane protein, multi-pass; Transcription factor P36956-3 6720 17p11.2 human S39-p 23940711 AGGTDPAsPDTSSPG transcription, induced 25353341 2 1 0 mRNA expression of central SREBP-1 target genes; Phosphorylation interferes with lipid metabolism and the secretory activity of liver cells. +LRP1 LRP1 Cell surface; Membrane protein, integral; Motility/polarity/chemotaxis; Receptor, misc. Q07954 4035 12q13.3 human S4520-p 450168 GGHGSRHsLASTDEK molecular association, regulation; receptor desensitization, altered; receptor internalization, altered GULP1(INDUCES); DAB1(INDUCES); SHC1(INDUCES) 11158305; 15272003 2 23 0 +EPAS1 HIF2A DNA-binding; Transcription factor Q99814 2034 2p21 human S672-p 56668652 APLGPPVsPPHVSTF molecular association, regulation; intracellular localization transcription, induced Exportin-1(DISRUPTS) 30962349 2 2 0 inhibition of CRM1-dependent nuclear export +NANOG NANOG Cell development/differentiation; DNA-binding; Transcription factor Q9H9S0 79923 12p13.31 human T78-p 28070706 SPKGKQPtSAEKSVA transcription, induced 23708658 1 2 0 +ILK ILK EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, Ser/Thr (non-receptor); Protein kinase, TKL Q13418 3611 11p15.4 human S246-p 479407 CPRLRIFsHPNVLPV PK_Tyr_Ser-Thr intracellular localization; phosphorylation carcinogenesis, induced; cell motility, induced; cell growth, induced; cell motility, altered; transcription, induced 17420447; 35810788 8 0 0 regulates GSK3B phosphorylation, and ?-catenin phosphorylation and nuclear translocation +DNPEP DNPEP iso2 EC 3.4.11.21; Protease Q9ULA0-2 23549 2q35 human S109-p 34733463 VKRRSRRsQVGFQQV Peptidase_M18 protein degradation; molecular association, regulation; ubiquitination carcinogenesis, inhibited; cell growth, inhibited; cell motility, inhibited; signaling pathway regulation USP4(DISRUPTS) 31219614 1 1 8 PAK5-DNPEP-USP4 pathway; inhibits invasion and migration +TLE1 TLE1 Nuclear receptor co-regulator; Transcription, coactivator/corepressor Q04724 7088 9q21.32 human S239-p 454385 KDSSHYDsDGDKSDD activity, induced apoptosis, inhibited; transcription, induced; transcription, altered; cell growth, altered 15367661; 22354967; 24270405 3 5 1 +Lrp1 LRP1 Cell surface; Membrane protein, integral; Motility/polarity/chemotaxis; Receptor, misc. G3V928 299858 7q22 rat Y4508-p 451245 TNFTNPVyATLYMGG molecular association, regulation GRB2(INDUCES); CSK(INDUCES); PLCG1(INDUCES); SNX17(DISRUPTS); SHP-2(INDUCES); 14-3-3 gamma(DISRUPTS); PIK3R1(INDUCES) 19771558 6 1 0 +SSH1 SSH1 EC 3.1.3.16; EC 3.1.3.48; PHOSPHATASE; Protein phosphatase, dual-specificity Q8WYL5 54434 12q24.11 human S978-p 455275 SPLKRSHsLAKLGSL molecular association, regulation; intracellular localization; activity, inhibited; phosphorylation cell motility, altered 14-3-3 beta(INDUCES); 14-3-3 zeta(INDUCES) 15159416; 19329994; 19567672; 21525957 9 1 0 +Slc10a1 NTCP Membrane protein, integral; Membrane protein, multi-pass; Transporter P26435 24777 6q24 rat T225-p 31080200 MTPHLLAtSSLMPFS endocytosis, induced 24008362 1 0 0 PMA induced internalization of NTCP +Slc12a5 KCC2 Membrane protein, integral; Membrane protein, multi-pass; Transporter; Transporter, SLC family Q63633 171373 3q42 rat S963-p 487533 ITDESRGsIRRKNPA SLC12 protein stabilization 17693402 23 5 2 +TARDBP TDP-43 RNA-binding Q13148 23435 1p36.22 human S410-p 3084601 SSMDSKSsGWGM___ molecular association, regulation; ubiquitination; intracellular localization; activity, inhibited; protein conformation; phosphorylation RNA splicing, induced; autophagy, induced; apoptosis, induced; RNA stability, inhibited; autophagy, altered; transcription, inhibited TDP-43(INDUCES); TDP-43(DISRUPTS) 19164285; 19515851; 21062285; 22198567; 24105464; 24466128; 24595055; 27445339; 28599005; 29311743; 29623031; 29987190; 30120199; 30559480; 34107054; 35112738 54 4 0 inhibited mTOR activity and dynactin expression, induced neuronal injury; primes phosphorylation at other sites; phosphomimetic S410/409D mutant reduces TARDBP aggregation and autophagy; induces cytotoxicity and oligomerization; promotes cytoplasmic aggregation +Icam1 ICAM1 Cell adhesion; Immunoglobulin superfamily; Membrane protein, integral P13597 15894 9 A3|9 7.69 cM mouse Y518-p 450460 RQRKIRIyKLQKAQE molecular association, regulation; intracellular localization cell adhesion, induced; cytoskeletal reorganization Actinfilin(INDUCES); ACTB(INDUCES) 21474822 5 0 1 +EWSR1 EWS Oncoprotein; RNA-binding; Transcription, coactivator/corepressor Q01844 2130 22q12.2 human Y656-p 20473605 QERRDRPy_______ intracellular localization 21647358 1 0 0 nuclear import +AMOTL1 AMOTL1 Adaptor/scaffold Q8IY63 154810 11q21 human S793-p 7103446 SSLRPARsVPSIAAA Angiomotin_C protein stabilization 25373897 1 20 2 +Fscn1 fascin Actin-binding; Cytoskeletal; Motility/polarity/chemotaxis Q61553 14086 5 G2|5 81.84 cM mouse S39-p 450888 KVNASASsLKKKQIW Fascin molecular association, regulation; intracellular localization cell motility, altered; cytoskeletal reorganization; signaling pathway regulation; cell adhesion, inhibited ACTA1(DISRUPTS); ACTB(DISRUPTS) 10588651; 16966425; 23884926; 28855604; 30683702 13 12 0 +ASB8 ASB8 Q9H765 140461 12q13.11 human S17-p 1869062300 QSIQSKYsLSERLIR signaling pathway regulation 32298923 1 0 0 IFN-beta signaling, TBK1/IKKi ubiquitination and degradation; inhibition of IRF3 pathway +LRP6 LRP6 Membrane protein, integral; Receptor, misc. O75581 4040 12p13.2 human S1420-p 460717 YVVHGPAsVPLGYVP molecular association, regulation carcinogenesis, induced; cell growth, induced; transcription, induced; signaling pathway regulation axin 1(DISRUPTS) 16513652; 35277657 2 0 0 induces Wnt/?-catenin signaling pathway +RACK1 RACK1 Adaptor/scaffold; G protein; G protein, heterotrimeric; G protein, heterotrimeric beta; Motility/polarity/chemotaxis; Nuclear receptor co-regulator P63244 10399 5q35.3 human Y302-p 2850000 GQTLFAGyTDNLVRV WD40 molecular association, regulation cell motility, altered; cell growth, altered PPP2CA(INDUCES); ITGB1(INDUCES) 18567578 1 0 0 phosphorylation of this site stimulates binding of RACK1 to PPP2CA, whereas does not affect its binding to ITGB1 +SLC3A2 SLC3A2 Membrane protein, integral; Transporter P08195 6520 11q12.3 human S408-p 6003503 TSSYLSDsGSTGEHT cell adhesion, altered 19065266 1 0 0 enhances cell- cell interactions +PFN1 profilin 1 Actin-binding; Cytoskeletal; Motility/polarity/chemotaxis P07737 5216 17p13.2 human S72-p 15413723 TLGGQKCsVIRDSLL Profilin molecular association, regulation; intracellular localization carcinogenesis, induced; apoptosis, inhibited; signaling pathway regulation; cell growth, altered ACTA1(DISRUPTS) 34235154 1 4 1 destabilizes I?Ba and increases NFkB signaling +TOM1L1 Srcasm Adaptor/scaffold O75674 10040 17q22 human Y392-p 451208 NLTSSHAyDNFLEHS molecular association, regulation; intracellular localization endocytosis, altered GRB2(INDUCES); EGFR(INDUCES) 19798056 3 0 1 regulates EGF-stimulated endocytosis of EGFR +F11R JAM-A Cell adhesion; Membrane protein, integral Q9Y624 50848 1q23.3 human T273-p 1783000 FDRTKKGtSSKKVIY cytoskeletal reorganization 18096610 1 1 0 important for development of hepatic polarity +Cdh1 CDH1 Cell adhesion; Membrane protein, integral; Motility/polarity/chemotaxis; UBIQUITIN LIGASE; Ubiquitin ligase P09803 12550 8 D3|8 53.18 cM mouse Y755-p 456024 DDTRDNVyYYDEEGG molecular association, regulation CBLL1(INDUCES) 11836526 2 2 42 +MAP4K3 KHS2 EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, STE; Protein kinase, Ser/Thr (non-receptor) Q8IVH8 8491 2p22.1 human Y735-p 23117826 LVVPEQEyPLVCVGV CNH molecular association, regulation IQGAP1(INDUCES) 31431460 0 1 1 +RASGRP3 RASGRP3 GEF; GEF, Ras Q5ZID9 421460 chicken T133-p 454419 YDWMRRVtQRKKISK activity, induced 15545601 2 0 0 +Map3k2 MEKK2 EC 2.7.11.25; KINASE; Kinase, protein; Protein kinase, STE; Protein kinase, Ser/Thr (non-receptor) F1M9D0 171492 18p12 rat S153-p 3216819 AERKKRLsVVGPPNR apoptosis, induced 28039298 3 51 11 +FPR1 FPR1 GPCR, family 1; Membrane protein, integral; Membrane protein, multi-pass; Motility/polarity/chemotaxis; Receptor, GPCR P21462 2357 19q13.41 human T334-p 450843 DSTQTSDtATNSTLP receptor desensitization, altered; receptor internalization, altered 10514456 2 1 0 +HSF1 HSF1 DNA-binding; Transcription factor Q00613 3297 8q24.3 human S338-p 40853700 IDSILREsEPAPASV Vert_HS_TF transcription, inhibited 25963659 1 0 0 under non-stressed conditions, upon heat shock S to A mutant showed 60% higher luciferase activity +RAG2 RAG2 Cell development/differentiation; Histone-binding; Lipid-binding P55895 5897 11p12 human T490-p 455560 EIARALHtPQRVLPL RAG2_PHD protein degradation; molecular association, regulation; ubiquitination carcinogenesis, altered SKP2(INDUCES) 15949444; 21349429 4 0 0 RAG2 T490A mutation induces lymphoid malignancies +LRP6 LRP6 Membrane protein, integral; Receptor, misc. O75581 4040 12p13.2 human S1431-p 460718 GYVPHPSsLSGSLPG molecular association, regulation axin 1(DISRUPTS) 16513652 1 0 0 +PLIN1 perilipin 1 Lipid-binding O60240 5346 15q26.1 human S522-p 471365 YSQLRKKs_______ intracellular localization 29688805 11 0 1 adrenergic control of lipolysis ; OPA1 is indispensable for HSL translocation to LDs and its phosphorylation on S650 and S552 +Smo SMO Cell development/differentiation; GPCR, Fz/Smo family; Membrane protein, integral; Membrane protein, multi-pass; Oncoprotein; Receptor, GPCR P56726 319757 6 A3.3|6 12.36 cM mouse S560-p 1872776110 WCRLTGHsDDEPKRI molecular association, regulation transcription, induced PKACA(INDUCES) 33886552 1 1 0 +RPA2 RFA2 DNA replication P15927 6118 1p35.3 human S13-p 1854601 FESYGSSsYGGAGGY molecular association, regulation; intracellular localization DNA repair, induced; cell growth, altered WRN(INDUCES) 17035231; 21107010 3 0 1 upon replication blockage, WRN and RPA functionally interact ; 7xAlanine mutant has defect in down regulating DNA synthesis following UV treatment. 7xAspartate mutant did not localize to S-phase foci. +Plk4 PLK4 EC 2.7.11.21; KINASE; Kinase, protein; Nucleolus; Protein kinase, Other; Protein kinase, Ser/Thr (non-receptor) Q64702 20873 3|3 B mouse S305-p 12122401 SGTSLSGsLLDRRLL protein degradation; ubiquitination; intracellular localization 20100909; 25174401 4 1 0 localizes in protrusions +S Spike Glycoprotein P59594 1489668 SARSCoV1 S1243-p 1868174975 CKFDEDDsEPVLKGV intracellular localization 16099010 1 1 0 retention of spike (S) glycoprotein at cell surface +LATS1 LATS1 EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, AGC; Protein kinase, Ser/Thr (non-receptor); Tumor suppressor O95835 9113 6q25.1 human K751-sm 62518205 RNQVAHVkAERDILA Pkinase enzymatic activity, inhibited; phosphorylation carcinogenesis, induced; cell growth, induced; apoptosis, inhibited; signaling pathway regulation 27847303 1 0 0 inhibition of Hippo signaling pathway, decrease in YAP and TAZ phosphorylation (Hippo pathway); Sumoylation of K751 destabilizes the phosphorylated T1079 resulting in a decrease of LATS1 enzymatic activity. +Gli2 GLI2 C2H2-type zinc finger protein; Oncoprotein; Transcription factor Q0VGT2 14633 1 E2.3|1 52.17 cM mouse S956-p 15501376 NSSTRRAsDPVRRPD sumoylation 22549777 1 5 4 +BTK Btk EC 2.7.10.2; KINASE; Kinase, protein; Protein kinase, TK; Protein kinase, tyrosine (non-receptor) Q06187 695 Xq22.1 human Y223-p 447485 LKKVVALyDYMPMNA SH3_1 enzymatic activity, induced cell adhesion, induced; cell growth, altered 14597636; 34162728; 37197664; 8630736 41 14 250 BTK*/Y223F mutant showed increased transformation, as compared to BTK*. +Ikzf1 Ikaros C2H2-type zinc finger protein; DNA-binding; Transcription factor Q03267 22778 11 A1|11 7.02 cM mouse S386-p 451350 SEREASPsNSCQDST activity, inhibited cell cycle regulation DNA(DISRUPTS) 15024069 2 1 2 +ATAT1 ATAT1 ACETYLTRANSFERASE; Acetyltransferase; EC 2.3.1.108 Q5SQI0 79969 6p21.33 human T322-p 480007 SPAQRRRtRGTPPGL molecular association, regulation; intracellular localization 14-3-3 beta(INDUCES); 14-3-3 zeta(INDUCES); 14-3-3 epsilon(INDUCES); 14-3-3 gamma(INDUCES); KPNA4(DISRUPTS); KPNA6(DISRUPTS); KPNA2(DISRUPTS) 36222836 1 0 2 +CHEK2 Chk2 EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, CAMK; Protein kinase, Ser/Thr (non-receptor); Tumor suppressor O96017 11200 22q12.1 human S73-p 2251701 VSTQELYsIPEDQEP molecular association, regulation; phosphorylation; enzymatic activity, induced cell cycle regulation 16481012 1 1 0 +CYLD CYLD DEUBIQUITINASE; EC 3.4.19.12; Protease; Tumor suppressor; Ubiquitin conjugating system; Ubiquitin-specific protease Q9NQC7 1540 16q12.1 human K338-ub 1878249900 SSSHNKPkATGSTSD protein degradation signaling pathway regulation 31366726 1 1 0 enhances NF-kB signaling. +TRIP6 TRIP6 Adaptor/scaffold; Motility/polarity/chemotaxis; Nuclear receptor co-regulator Q15654 7205 7q22.1 human Y55-p 456050 PLPSEQCyQAPGGPE molecular association, regulation; intracellular localization carcinogenesis, altered; cell motility, induced; cell motility, altered 17591779; 20876301; 23576104 5 4 43 +TP63 p63 DNA-binding; Transcription factor Q9H3D4 8626 3q28 human S395-p 451602 TSIKKRRsPDDELLY P53_tetramer transcription, induced 35623662 2 4 0 +DCLRE1C Artemis DNA repair, damage; Deoxyribonuclease; EC 3.1.-.- Q96SD1 64421 10p13 human S516-p 460660 SSTVAGGsQSPKLFS molecular association, regulation; ubiquitination; intracellular localization cell cycle regulation FBXW7(INDUCES); NBS1(INDUCES); MRE11A(INDUCES) 15723659; 16600297; 17242184; 19423708 8 3 1 facilitates recovery from the replication checkpoint in response to DNA damage; Artermis regulates Cdk1-cyclin B during IR-induced G2/M arrest and Cdk1-cyclin B nuclear import.; interaction with FBXW7 stimulates ubiquitination and degradation of cyclin E +TERF2 TRF2 DNA repair, damage; DNA-binding Q15554 7014 16q22.1 human R60-me 10338213 SGRAAGRrASRSSGR cell cycle regulation; cell growth, altered 19596784 1 0 0 +CEACAM1 CEACAM1 Cell adhesion; Immunoglobulin superfamily; Membrane protein, integral; Motility/polarity/chemotaxis P13688 634 19q13.2 human S508-p 448536 QQPTQPTsASPSLTA activity, induced; molecular association, regulation; intracellular localization; enzymatic activity, induced; phosphorylation apoptosis, induced; transcription, altered; cell growth, altered CD36(DISRUPTS) 11278391; 11313949; 23499736; 34656562; 34666041 11 2 0 regulates CD36 nuclear translocation, inhibits AMPK phosphorylation and activation; influences phosphorylation of residues Y493 and Y520 +NEK7 NEK7 EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, Other; Protein kinase, Ser/Thr (non-receptor) Q8TDX7 140609 1q31.3 human Y97-p 12475500 NHPNVIKyYASFIED Pkinase enzymatic activity, inhibited; protein conformation apoptosis, altered 19941817 1 0 0 autoinhibition +CAMK4 CAMK4 EC 2.7.11.17; KINASE; Kinase, protein; Protein kinase, CAMK; Protein kinase, Ser/Thr (non-receptor) Q16566 814 5q22.1 human T200-p 448164 EHQVLMKtVCGTPGY Pkinase molecular association, regulation; enzymatic activity, induced transcription, induced; transcription, altered OGA(DISRUPTS) 15143065; 15769749; 19506079; 8702940 11 7 8 +Cbl CBL Adaptor/scaffold; EC 6.3.2.-; EC 6.3.2.19; Ligase; Motility/polarity/chemotaxis; Oncoprotein; UBIQUITIN LIGASE; Ubiquitin conjugating system; Ubiquitin ligase P22682 12402 9 A5.1-A5.2|9 24.72 cM mouse Y737-p 448530 QQIDSCTyEAMYNIQ molecular association, regulation; phosphorylation cytoskeletal reorganization Src(INDUCES) 20133944; 21967979; 34019873 17 1 34 +RET Ret EC 2.7.10.1; KINASE; Kinase, protein; Membrane protein, integral; Oncoprotein; Protein kinase, TK; Protein kinase, tyrosine (receptor) P07949 5979 10q11.21 human S891-p 455478 EGRKMKIsDFGLSRD PK_Tyr_Ser-Thr phosphorylation transcription, altered 15753368 1 0 0 STAT3 Y705 phosphorylation +DDX19A DDX19A EC 3.6.4.13; Helicase Q9NUU7 55308 16q22.1 human K26-sm 55429484 SMTNLQIkEEKVKAD molecular association, regulation; intracellular localization GLE1(INDUCES) 35080244 1 3 0 enriched at the nuclear envelope, regulates mRNA export from nucleus +SMURF2 SMURF2 EC 6.3.2.-; EC 6.3.2.19; Ligase; UBIQUITIN LIGASE; Ubiquitin conjugating system; Ubiquitin ligase Q9HAU4 64750 17q23.3-q24.1 human R232-m1 56854401 DPRLAERrVRSQRHR protein degradation 26126536 1 0 0 +AURKA AurA EC 2.7.11.1; KINASE; Kinase, protein; Oncoprotein; Protein kinase, Other; Protein kinase, Ser/Thr (non-receptor) O14965 6790 20q13.2 human K75-ac 1873284338 HKPVQNQkQKQLQAT enzymatic activity, induced cell cycle regulation; carcinogenesis, induced; cell motility, induced; cell growth, induced 28915666 1 0 0 may lead to development of cancer +Fcer1g FCER1G Membrane protein, integral; Receptor, misc. P20491 14127 1 H3|1 79.23 cM mouse Y76-p 454847 NTRSQETyETLKHEK ITAM molecular association, regulation; phosphorylation endocytosis, induced Syk(INDUCES); Cbl-b(DISRUPTS) 18715866; 27428899 4 16 204 +PIN1 PIN1 EC 5.2.1.8; Isomerase; Nuclear receptor co-regulator Q13526 5300 19p13.2 human K6-sm 31094510 __MADEEkLPPGWEK protein degradation; molecular association, regulation; enzymatic activity, inhibited carcinogenesis, inhibited; cell growth, inhibited; transcription, inhibited FOXM1(DISRUPTS) 23633483 1 2 0 inhibits cyclin D1 stability +STXBP5L STXBP5L Q9Y2K9 9515 3q13.33 human S820-p 3941523 YNRSRSSsISSIDKD Lgl_C protein degradation 25002582 1 8 14 ; in a multiple residue S->D mutant +DOCK8 DOCK8 GEF; GEF, misc.; Motility/polarity/chemotaxis Q8NF50 81704 9p24.3 human S2087-p 4041179 RDSFHRSsFRKCETQ molecular association, regulation cell motility, induced LRCH1(DISRUPTS) 28028151 1 2 7 +CHEK1 Chk1 EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, CAMK; Protein kinase, Ser/Thr (non-receptor); Tumor suppressor O14757 1111 11q24.2 human T382-p 1388511400 KRMTRFFtKLDADKS protein degradation; enzymatic activity, induced cell cycle regulation 30510197 1 0 0 +Gja1 GJA1 Channel, misc.; Membrane protein, integral; Membrane protein, multi-pass; Motility/polarity/chemotaxis P08050 24392 20q11 rat S255-p 448852 HATTGPLsPSKDCGS activity, inhibited 9535909 23 21 1 +Kdr VEGFR2 EC 2.7.10.1; KINASE; Kinase, protein; Membrane protein, integral; Protein kinase, TK; Protein kinase, tyrosine (receptor) P35918 16542 5 C3.3|5 40.23 cM mouse Y994-p 447904 EEASEELyKDFLTLE PK_Tyr_Ser-Thr signaling pathway regulation 25119572 7 0 0 +KLF3 KLF3 C2H2-type zinc finger protein; DNA-binding; Transcription factor P57682 51274 4p14 human S250-p 4728795 KRPLPVEsPDTQRKR molecular association, regulation transcription, inhibited DNA(INDUCES) 25659434 1 41 0 +GTSE1 GTSE1 Apoptosis; Cell cycle regulation Q9NYZ3 51512 22q13.31 human S454-p 10405611 RSIRRRDsCLNSKTK intracellular localization cell cycle regulation 20577264 1 4 27 important for p53 inactivation during G2 checkpoint recovery +Hsf1 HSF1 DNA-binding; Transcription factor P38532 15499 15 D3|15 35.95 cM mouse S121-p 455480 NIKRKVTsVSTLKSE intracellular localization; activity, inhibited 25425574 5 7 1 HSF1 inactivation, supresses Proteotoxic stress response, impaired nuclear translocation +SVIL supervillin Actin-binding; Contractile; Motility/polarity/chemotaxis; Nuclear receptor co-regulator Q6U1J6 ferret S132-p 7721700 DSEADSEsPSRYTKS molecular association, regulation ERK1(DISRUPTS); ERK2(DISRUPTS) 19406750 1 3 11 in vitro +Arhgef7 ARHGEF7 GEF; GEF, Rac/Rho; Motility/polarity/chemotaxis O55043 114559 16q12.5 rat S516-p 455215 RKPERKPsDEEFAVR RhoGEF67_u2 molecular association, regulation; intracellular localization cytoskeletal reorganization 14-3-3 beta(INDUCES); CDC42 iso1(INDUCES); RAC1(INDUCES) 15513924; 18160719; 18184567 4 54 30 +PAK3 PAK3 EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, STE; Protein kinase, Ser/Thr (non-receptor) O75914 5063 Xq23 human S259-p 470118 TDRQRKKsKMTDEEI cytoskeletal reorganization 17077177 1 0 0 Mutation of any of the 4 serines/threonines to alanine reduced the AILIM/ICOS-induced elongation ratio in activated T cells. Three sites are believed to be autophosphorylation sites, and one is believed to be an Akt1 site. Treatment with Akt inhibitor shows a reduction in this elongation ratio. +SLC9A1 NHE1 Membrane protein, integral; Membrane protein, multi-pass; Motility/polarity/chemotaxis; Transporter; Transporter, SLC family P19634 6548 1p36.11 human S785-p 1983418 FTPAPSDsPSSQRIQ activity, induced; protein stabilization; protein conformation 23678047; 28554535 3 49 28 +Dnm2 DYN2 EC 3.6.5.5; Hydrolase; Microtubule-binding; Motility/polarity/chemotaxis; Vesicle P39052 25751 8q13 rat Y231-p 451199 LLPLRRGyIGVVNRS Dynamin_M molecular association, regulation; intracellular localization carcinogenesis, induced; cell motility, induced; cell growth, induced; exocytosis, induced; cytoskeletal reorganization caveolin-1(INDUCES) 15007081; 20231454; 21841817 4 1 0 DYN2 Y597 is required for endocytosis and albumin transport. ; Golgi integrity and vesiculation during the secretory process; Wild-type showed increased motility and increase of large distal tumors, compared to Y231/597F mutant. +Hcn4 HCN4 Channel, cation; Membrane protein, integral; Membrane protein, multi-pass O70507 330953 9|9 B mouse S1142-p 4699522 PRKTSSGsLPPPLSL activity, induced 20713547 1 0 0 required for PKA to shift the voltage dependence of HCN4 +Diaph3 Diaphanous-3 Motility/polarity/chemotaxis Q9Z207 56419 14|14 E1 mouse T1061-p 20583304 FRDRRKRtPKLKDIR activity, induced; molecular association, regulation; intracellular localization; protein conformation transcription, induced; cytoskeletal reorganization Diaphanous-3(DISRUPTS) 21699497 1 0 0 +YBX1 YB-1 RNA processing; RNA splicing; RNA-binding; Transcription factor P67809 4904 1p34.2 human K264-m2 1884032900 EDGNEEDkENQGDET molecular association, regulation carcinogenesis, induced; cell motility, induced; cell growth, induced RNA(INDUCES) 35410432 1 1 0 K264 methylation is involved in hY4F binding and sorting into lung cancer EVs; role in the proliferation, migration and invasion +SLC22A6 SLC22A6 Membrane protein, integral; Membrane protein, multi-pass; Transporter; Transporter, SLC family Q4U2R8 9356 11q12.3 human K315-ub 27202153 VLRASLQkELTMGKG Sugar_tr receptor internalization, induced 23640180 1 1 0 +ZMYM2 ZNF198 Transcription factor Q9UBW7 7750 13q12.11 human S303-p 18914809 QKQPGVDsLSPVASL molecular association, regulation; ubiquitination HDAC1(DISRUPTS); LSD1(DISRUPTS) 25855382 1 4 0 +ERBB2 HER2 EC 2.7.10.1; KINASE; Kinase, protein; Membrane protein, integral; Oncoprotein; Protein kinase, TK; Protein kinase, tyrosine (receptor) P04626 2064 17q12 human K175-m3 206216900 LWKDIFHkNNQLALT molecular association, regulation; phosphorylation signaling pathway regulation HER2(INDUCES) 28639750 1 1 0 induces HER2 autophosphorylation, homodimerization, activates Akt and PLC-gamma signaling pathways +Olig2 OLIG2 Oncoprotein; Transcription factor Q9EQW6 50913 16 C3.3|16 52.6 cM mouse S10-p 18357903 SDASLVSsRPSSPEP sumoylation cell cycle regulation; cell differentiation, altered; carcinogenesis, altered; cell growth, induced; apoptosis, inhibited; transcription, induced; cell motility, inhibited 21382551; 27396340; 32483381 4 2 0 +DNMT1 DNMT1 Amino Acid Metabolism - cysteine and methionine; Cell development/differentiation; EC 2.1.1.37; METHYLTRANSFERASE; Methyltransferase; Methyltransferase, DNA; Transcription regulation P26358 1786 19p13.2 human K975-ac 25171007 LYPEHYRkYSDYIKG BAH cell cycle regulation 21947282 1 1 0 +NME1 NME1 EC 2.7.4.6; KINASE; Kinase, nucleoside diphosphate; Kinase, other; Nucleotide Metabolism - purine; Nucleotide Metabolism - pyrimidine; Protein kinase, histidine; Tumor suppressor P15531 4830 17q21.33 human K56-ac 11319284 KEHYVDLkDRPFFAG NDK protein stabilization; molecular association, regulation cell motility, inhibited FBXO24(DISRUPTS) 25582197 1 4 0 +ITCH ITCH EC 6.3.2.-; EC 6.3.2.19; Ligase; UBIQUITIN LIGASE; Ubiquitin conjugating system; Ubiquitin ligase Q96J02 83737 20q11.22 human S687-p 397383600 IDPEFYNsLIWVKEN HECT molecular association, regulation UBE2L3(DISRUPTS) 29212706 1 0 0 +Slc40a1 SLC40A1 Membrane protein, integral; Membrane protein, multi-pass; Transporter; Transporter, SLC family Q9JHI9 53945 1|1 C1.1 mouse K240-ub 3937703 LAVKAALkVEESELK FPN1 sumoylation; ubiquitination; intracellular localization 33490642 1 2 2 Sumoylation of K240E mutation impedes Fpn trafficking and is diffused throughout the cytoplasm, and affects iron homeostasis. +Rb1 Rb Nuclear receptor co-regulator; Oncoprotein; Transcription, coactivator/corepressor; Tumor suppressor P13405 19645 14 38.73 cM|14 D3 mouse T814-p 447983 KISEGLPtPTKMTPR Rb_C molecular association, regulation; phosphorylation cell cycle regulation; chromatin organization, altered; cell growth, induced; DNA repair, inhibited E2F1(DISRUPTS); SUV420H1(DISRUPTS); SUV420H2(DISRUPTS) 10207050; 35023164 26 40 64 +Hoxa9 HOXA9 DNA-binding; Oncoprotein P09631 15405 6 B3|6 25.4 cM mouse T205-p 2906101 NWLHARStRKKRCPY molecular association, regulation cell differentiation, altered DNA(DISRUPTS) 15082777 1 0 0 +JUNB JunB Motility/polarity/chemotaxis; Oncoprotein; Transcription factor P17275 3726 19p13.13 human S259-p 452631 RDATPPVsPINMEDQ protein degradation FBXW7(INDUCES) 22710716 4 55 19 mitosis progression and chromatid cohesion +Ulk1 ULK1 Autophagy; EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, Other; Protein kinase, Ser/Thr (non-receptor) NP_001101811 360827 12q16 rat S317-p 35495300 SHLASPPsLGEMPQL autophagy, induced 33571535; 37009319 20 1 0 +NCOA3 SRC-3 ACETYLTRANSFERASE; Acetyltransferase; EC 2.3.1.48; Motility/polarity/chemotaxis; Nuclear receptor co-regulator; Transcription, coactivator/corepressor Q9Y6Q9 8202 20q13.12 human S101-p 4661901 DVQKADVsSTGQGVI protein degradation; molecular association, regulation carcinogenesis, inhibited SPOP(INDUCES) 18922467; 21577200 2 0 0 +PPARGC1A PGC-1 alpha Nuclear receptor co-regulator; Transcription, coactivator/corepressor Q9UBK2 10891 4p15.2 human S636-p 15422179 SRRPRYDsYEEYQHE protein degradation; molecular association, regulation; ubiquitination; phosphorylation carcinogenesis, induced; DNA repair, induced; apoptosis, inhibited RNF34(INDUCES) 36696363 1 1 4 decreases H2AX phosphorylation +FLT3 FLT3 EC 2.7.10.1; KINASE; Kinase, protein; Membrane protein, integral; Oncoprotein; Protein kinase, TK; Protein kinase, tyrosine (receptor) P36888 2322 13q12.2 human Y969-p 454874 VSECPHTyQNRRPFS molecular association, regulation cell cycle regulation GRB2(INDUCES); Btk(NOT_REPORTED); SHP-2(INDUCES) 19438505; 31395602 6 4 16 regulates cell proliferation +CREB1 CREB iso1 DNA-binding; Transcription factor P16220-1 1385 2q33.3 human T100-p 457131 LKRLFSGtQISTIAE activity, inhibited; phosphorylation transcription, inhibited 15073328; 17209043 3 0 0 +FLI1 FLI1 DNA-binding; Oncoprotein; Transcription factor Q01543 2313 11q24.3 human K240-ac 28108002 NMNSGLNkSPPLGGA transcription, induced 22973553 1 1 0 +Sp1 SP1 C2H2-type zinc finger protein; DNA-binding; Transcription factor Q01714 24790 7q36 rat K704-ac 12718501 MRSDHLSkHIKTHQN zf-C2H2 molecular association, regulation apoptosis, induced; transcription, induced DNA(INDUCES) 34504597 3 0 0 +TP53 p53 Activator; DNA-binding; Motility/polarity/chemotaxis; Nuclear receptor co-regulator; Transcription factor; Tumor suppressor P04637 7157 17p13.1 human T284-p 18675300 CPGRDRRtEEENLRK P53 apoptosis, altered; transcription, inhibited 20959462 1 1 0 +Cacna1c CACNA1C Channel, calcium; Membrane protein, integral; Membrane protein, multi-pass P22002 24239 4q42 rat Y1738-p 880751700 LFGNHVSyYQSDSRS CAC1F_C activity, induced 29441404 1 0 0 significantly increased the Ca2+current density of CACNA1C channels in a range of the membrane potentials +PPARD PPAR-delta DNA-binding; Nuclear receptor A9XAM2 pig K17-ub 62484401 EVREEEKkKEVAEAE transcription, induced 24058710 1 0 0 +MFN2 MFN2 Cell cycle regulation; Cytoskeletal; EC 3.6.5.-; Hydrolase; Membrane protein, integral; Membrane protein, multi-pass; Mitochondrial O95140 9927 1p36.22 human S442-p 4746700 AEEIRRLsVLVDDYQ protein degradation; intracellular localization cell cycle regulation; carcinogenesis, induced; autophagy, induced; cell growth, induced; apoptosis, inhibited 34275172; 35646911 6 2 0 miophagy +Wasf2 WAVE2 Actin-binding; Motility/polarity/chemotaxis Q5FWU0 313024 5q36 rat S137-p 4258800 PPPLNNLsPYRDDGK cell motility, altered 18701695 2 0 0 +Trp53bp1 53BP1 DNA repair, damage; Transcription, coactivator/corepressor P70399 27223 2|2 E5 mouse K1265-ub 7172000 DGTEVERkVTEETEE intracellular localization DNA repair, induced 19228710 1 0 0 +Kcnk18 KCNK18 Channel, ligand-gated; Channel, potassium; Membrane protein, integral; Membrane protein, multi-pass Q6VV64 332396 19|19 D3 mouse S264-p 2712200 RPVERSNsCPELVLG activity, induced; molecular association, regulation; protein conformation; activity, inhibited 14-3-3 beta(INDUCES); 14-3-3 gamma(INDUCES); 14-3-3 eta(INDUCES) 14981085; 18397886; 20215114; 22145024; 29763475; 32641496 8 0 1 +Dab2 DAB2 Adaptor/scaffold; Tumor suppressor P98078 13132 15 A1|15 2.15 cM mouse S24-p 451211 QAAPKAPsKKEKKKG molecular association, regulation; receptor internalization, inhibited VEGFR2(DISRUPTS); VEGFR3(DISRUPTS) 23354168 4 3 0 +Hnf4a HNF4 alpha DNA-binding; Nuclear receptor; Transcription factor P22449 25735 3q42 rat S143-p 458369 RISTRRSsYEDSSLP molecular association, regulation transcription, altered DNA(DISRUPTS) 9234678 4 3 12 +RPS3 RPS3 Apoptosis; EC 4.2.99.18; RNA-binding; Ribosomal; Translation P23396 6188 11q13.4 human T70-p 15113600 GRRIRELtAVVQKRF KH_2 activity, induced; molecular association, regulation; intracellular localization apoptosis, altered E2F1(DISRUPTS); Akt1(INDUCES) 20605787 3 2 0 upregulates the endonuclease activity of RPS3 +PDE4D PDE4D iso7 EC 3.1.4.53; Nucleotide Metabolism - purine; Phosphodiesterase Q08499-7 5144 5q11.2-q12.1 human S126-p 458388 VHSQRREsFLYRSDS enzymatic activity, induced 12023945 10 21 1 +App APP Apoptosis; Cell surface; Membrane protein, integral; Receptor, misc.; Transcription factor P12023 11820 16 C3.3|16 46.92 cM mouse S697-p 54165901 FFAEDVGsNKGAIIG Beta-APP protein conformation 26898910 2 0 0 forms oligomers without fibril formation, intraneuronal deposition, increased toxicity in human neurons +Exoc7 EXOC7 Cytoskeletal O54922 64632 10q32.1 rat S250-p 483909 SSSGVPYsPAIPNKR molecular association, regulation exocytosis, induced; cell motility, induced; cytoskeletal reorganization EXOC4(INDUCES); EXOC8(INDUCES) 22595671 1 25 6 +TRIM59 TRIM59 Membrane protein, integral; Ubiquitin conjugating system Q8IWR1 286827 3q25.33 human S308-p 50801655 LIPKMKIsPKRMSCS protein degradation; molecular association, regulation; ubiquitination; intracellular localization; protein conformation carcinogenesis, induced; transcription, induced; signaling pathway regulation H2AFY iso1(INDUCES); KPNA1(INDUCES); PIN1(INDUCES) 31488827 1 1 0 macroH2A1 degradation enhances STAT3 signaling; CDK5/TRIM59/mH2A1/STAT3 pathway +PHF8 PHF8 DEMETHYLASE; Demethylase; EC 1.14.11.27; Nucleolus Q9UPP1 23133 Xp11.22 human S69-p 15108901 CQDWFHGsCVGVEEE PHD cell growth, inhibited; cell differentiation, induced; transcription, induced 23518351 2 1 0 +AXL AXL EC 2.7.10.1; KINASE; Kinase, protein; Membrane protein, integral; Oncoprotein; Protein kinase, TK; Protein kinase, tyrosine (receptor) P30530 558 19q13.2 human Y779-p 451490 ADCLDGLyALMSRCW PK_Tyr_Ser-Thr apoptosis, inhibited; transcription, induced 33786587 8 2 2 +DEPDC1 DEPDC1 GAP; GAP, Rac/Rho Q5TB30 55635 1p31.3 human S110-p 31082615 LFRFPATsPLKTLPR intracellular localization 28602627 1 3 0 localization of DEPDC1a to the centrosome +Grm5 mGluR5 GPCR, family 3; Membrane protein, integral; Membrane protein, multi-pass; Receptor, GPCR Q3UVX5 108071 7|7 D3 mouse S1158-p 25581600 LVALTPPsPFRDSVD GluR_Homer-bdg molecular association, regulation; protein conformation PIN1(INDUCES); HOMER1(INDUCES) 22561452; 23911326 4 0 0 increases mGluR5-dependent NMDAR current, necessary for Cocaine-sensitivity, HOMER1a enables Pin1 interaction; FRMPD4 required for binding; reduced signaling prevents inflammatory pain +RPS6KB1 p70S6K EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, AGC; Protein kinase, Ser/Thr (non-receptor); Translation P23443 6198 17q23.1 human T252-p 448606 HDGTVTHtFCGTIEY Pkinase molecular association, regulation; protein conformation; phosphorylation; enzymatic activity, induced translation, altered; cell growth, inhibited; translation, inhibited ELF4(DISRUPTS); ELF3(INDUCES) 11684675; 12970779; 19864428; 21561857; 21986499; 7489717; 7545671; 9218810; 9445476 36 2 17 +RRN3 TIF1A Nucleolus; Transcription initiation complex Q9NYV6 54700 16p13.11 human S170-p 470001 KEGDVDVsDSDDEDD RRN3 activity, induced; protein stabilization; molecular association, regulation; intracellular localization cell cycle regulation; chromatin organization, altered; transcription, induced POLM(DISRUPTS); TWISTNB(DISRUPTS) DNA(INDUCES) 18559419; 24297901; 27257073 3 24 2 rDNA transcription; rRNA synthesis induced +KRT18 K18 Cytoskeletal; Nucleolus P05783 3875 12q13.13 human S31-gl 6778601 YGARPVSsAASVYAG protein degradation; phosphorylation cell motility, induced; apoptosis, inhibited; cytoskeletal reorganization 20729838; 27059955 4 1 0 K18?Gly? mutation alters protein kinase phosphorylation and promotes apoptosis in response to STZ treatment; Akt1 Thr 308 phosphorylation increased 12 h after STZ treatment in livers of mice expressing wild-type K18, but in K18?Gly? inhibits Akt1 Thr 308 phosphorylation; glycosylation promotes th the phosphorylation and activation of cell-survival kinases; maintaining the normal filament organization of keratin 18 +DEPTOR DEPTOR Apoptosis Q8TB45 64798 8q24.12 human S293-p 3897131 SSGYFSSsPTLSSSP protein degradation; molecular association, regulation carcinogenesis, induced; apoptosis, inhibited; signaling pathway regulation BTRC(INDUCES); mTOR(DISRUPTS) 19446321; 22017875; 22017877 3 5 3 PI3K-Akt signaling +Kcnj3 GIRK1 Channel, potassium; Membrane protein, integral; Membrane protein, multi-pass P63251 50599 3q21 rat S401-p 10769100 DISTKLPsKLQKITG activity, induced 19765080 2 0 0 +RPS6KA3 RSK2 EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, AGC; Protein kinase, Ser/Thr (non-receptor) P51812 6197 Xp22.12 human T577-p 450152 AENGLLMtPCYTANF Pkinase phosphorylation; enzymatic activity, induced 10980595; 36806093 10 14 180 induces phosphorylation at S227 +EGFR EGFR EC 2.7.10.1; KINASE; Kinase, protein; Membrane protein, integral; Oncoprotein; Protein kinase, TK; Protein kinase, tyrosine (receptor) P00533 1956 7p11.2 human Y998-p 452118 SPTDSNFyRALMDEE receptor internalization, induced; protein degradation; molecular association, regulation; receptor internalization, altered; phosphorylation STAT5A(INDUCES); CSK(INDUCES); SHC1(INDUCES); SHP-2(INDUCES); CBL(INDUCES); CRK(INDUCES) 16729043; 19531499; 24797263 4 29 134 +RALBP1 RALBP1 GAP; GAP, Rac/Rho Q15311 10928 18p11.22 human S509-p 3136100 FLRRQIAsEKEEIER activity, induced 16087181 1 0 0 +KRT8 K8 Cytoskeletal P05787 3856 12q13.13 human T67-p 15420556 MGGITAVtVNQSLLS Keratin_2_head cytoskeletal reorganization 27403885 1 2 1 phosphorylation reduces keratin filament length, formation of connectivity-depleted and mechanically weaker networks +JAK2 JAK2 EC 2.7.10.2; KINASE; Kinase, protein; Oncoprotein; Protein kinase, TK; Protein kinase, tyrosine (non-receptor) O60674 3717 9p24.1 human K1011-sm 31899105 DKEYYKVkEPGESPI PK_Tyr_Ser-Thr molecular association, regulation; intracellular localization GH receptor(DISRUPTS) 23581279 1 0 0 translocation into the nucleus +TRAF3 TRAF3 UBIQUITIN LIGASE; Ubiquitin conjugating system; Ubiquitin ligase Q13114 7187 14q32.32 human K154-ub 1881306700 PCVRPDCkEKVLRKD molecular association, regulation TBK1(INDUCES) 33975961 1 0 0 interaction between TRAF3 and Avibirnavirus VP3 was enhanced in KEK293T cells overexpressing K33 ubiquitin, TRAF3 K154 is necessary for VP3 to downregulate IFN-beta production +KCNJ12 KCNJ12 Membrane protein, integral; Membrane protein, multi-pass Q14500 3768 17p11.2 human S64-p 3053612 FANMDEKsQRYLADM IRK activity, inhibited 12234954 1 0 0 +Psmc1 RPT2 Protease; Proteasome complex P62192 19179 12 E|12 50.43 cM mouse Y439-p 451910 EGTPEGLyL______ protein stabilization carcinogenesis, induced; apoptosis, inhibited CP(DISRUPTS) 33603165 1 6 138 +CTCF CTCF C2H2-type zinc finger protein; Transcription factor; Tumor suppressor Q08705 396274 chicken S604-p 448302 GRKRKMRsKKEDSSD transcription, altered; cell growth, altered 11238955 1 0 1 +MAPK6 ERK3 EC 2.7.11.24; KINASE; Kinase, protein; Protein kinase, CMGC; Protein kinase, Ser/Thr (non-receptor) Q16659 5597 15q21.2 human T698-p 13830502 KSIQATLtPSAMKSS protein stabilization 20236090 1 1 0 +CLDN5 Claudin-5 Cytoskeletal; Membrane protein, integral; Membrane protein, multi-pass O00501 7122 22q11.21 human Y148-p 4122714 NIVVREFyDPSVPVS PMP22_Claudin cytoskeletal reorganization 22671590 1 1 0 +SLC9A1 NHE1 Membrane protein, integral; Membrane protein, multi-pass; Motility/polarity/chemotaxis; Transporter; Transporter, SLC family P19634 6548 1p36.11 human S729-p 3181649 ASPQSPEsVDLVNEE activity, induced apoptosis, induced 18701649 3 7 2 regulates the apoptotic alkalinizing activity of NHE1 +POLI POLI DNA repair, damage; EC 2.7.7.7; Transferase Q9UNA4 11201 18q21.2 human K345-ub 50771302 SEVEAKNkIEELLAS IMS_C protein degradation 26370087 1 2 0 +PRKN PARK2 EC 6.3.2.-; EC 6.3.2.19; Ligase; Translation; Translation regulation; UBIQUITIN LIGASE; Ubiquitin conjugating system; Ubiquitin ligase O60260 5071 6q26 human S378-p 454424 AYHEGECsAVFEASG molecular association, regulation; enzymatic activity, induced cell cycle regulation; carcinogenesis, inhibited CDC20(INDUCES) 26387737 4 1 1 important in mitosis +FOXM1 FOXM1 iso2 DNA-binding; Transcription factor Q08050-2 2305 12p13.33 human T596-p 451437 ETLPISStPSKSVLP molecular association, regulation transcription, induced CBP(INDUCES) 15024056 4 3 3 +STAT1 STAT1 DNA-binding; Transcription factor P42224 6772 2q32.2 human K652-ub 12108418 PDIIRNYkVMAAENI SH2 ubiquitination IFNAR2(DISRUPTS) 32123171 1 7 12 linear ubiquitination of K511 and K652 and inhibits interaction with INFAR2, INF-I stimulation removes STAT1 linear ubiquitination, viruses upregulate HOIP and STAT1 linear ubiquitination +AKAP4 AKAP4 Adaptor/scaffold; Cancer Testis Antigen (CTA) Q5JQC9 8852 Xp11.22 human T265-p 457176 KERISPRtPASKIAS AKAP_110 intracellular localization 27901058 1 2 0 localization to Golgi +Ric8a RIC8A GEF; GEF, misc. NP_001093990 293614 1q41 rat T440-p 468628 QYSEDEDtDTEEYRE Ric8 activity, induced; protein stabilization; molecular association, regulation; protein conformation G-alpha i1(INDUCES) 29844055; 31155309; 31300652 2 56 75 G-alpha subunit guanine nucleotide exchange; G-alpha subunit folding; Phosphorylation at S435 and T440 augment stabilization of intramolecular electrostatic interactions in RIC8A; induces GEF activity +NUSAP1 NUSAP1 Cell cycle regulation; Nucleolus Q9BXS6 51203 15q15.1 human S124-p 482179 QNHEKQEsQDLRATA cell cycle regulation 21130744 1 4 4 +Il22ra1 IL22RA1 Membrane protein, integral Q80XZ4 230828 4 D3|4 67.99 cM mouse S410-p 23115552 YAVCVEDsGKDSTPG protein stabilization 24742671 1 0 1 +DVL2 DVL2 Adaptor/scaffold; Motility/polarity/chemotaxis O14641 1856 17p13.1 human K428-ub 41486014 TDMASVTkAMAAPES molecular association, regulation; intracellular localization cell motility, induced; signaling pathway regulation Cofilin-1(INDUCES); VANGL1(INDUCES) 31340145 1 4 0 DVL2 variant with all encoded lysine residues mutated to arginine is sufficient to restore WNT activation +Fxyd1 PLM Cell surface; Channel, misc.; Membrane protein, integral O08589 58971 1q21 rat S83-p 451424 EEGTFRSsIRRLSTR activity, induced; molecular association, regulation; intracellular localization ZDHHC5(INDUCES); caveolin-3(DISRUPTS) 16434394; 19339511; 23532852; 25422474 22 20 60 +BLNK BLNK Adaptor/scaffold Q8WV28 29760 10q24.1 human S285-p 7603541 AERHRGSsHRQEAVQ molecular association, regulation 14-3-3 sigma(INDUCES); 14-3-3 zeta(INDUCES); 14-3-3 gamma(INDUCES) 33176192 1 1 0 +ABL1 Abl EC 2.7.10.2; KINASE; Kinase, protein; Oncoprotein; Protein kinase, TK; Protein kinase, tyrosine (non-receptor) P00519 25 9q34.12 human Y139-p 456712 VSRNAAEyLLSSGIN SH2 enzymatic activity, induced 18775312 2 0 57 SH2 and catalytic domains of Fes and Abl interact with ligand, stimulating kinase activity. +TJP2 ZO2 Adaptor/scaffold; Motility/polarity/chemotaxis Q95168 403854 dog S257-p 28700303 PDARHAGsRSRSREH intracellular localization 23804652 1 0 0 +Erbb2 HER2 EC 2.7.10.1; KINASE; Kinase, protein; Membrane protein, integral; Oncoprotein; Protein kinase, TK; Protein kinase, tyrosine (receptor) P06494 24337 10q31 rat Y1223-p 449744 SPAFDNLyYWDQNSS molecular association, regulation apoptosis, altered SHC1(DISRUPTS) 19826412 34 1 14 inhibits apoptosis +HTT Huntingtin Cytoskeletal P42858 3064 4p16.3 human S13-p 10206805 KLMKAFEsLKSFQQQ receptor internalization, induced; molecular association, regulation; intracellular localization; protein conformation exocytosis, inhibited; apoptosis, inhibited; cytoskeletal reorganization HMGB1(INDUCES); Huntingtin(INDUCES); Huntingtin(DISRUPTS); Exportin-1(DISRUPTS) 21623356; 23297360; 24334607; 24505464; 28698602; 30185623; 30538129; 32757223; 33256402; 35780830 19 3 0 +PDHA1 PDHA1 Amino Acid Metabolism - valine, leucine and isoleucine biosynthesis; Carbohydrate Metabolism - butanoate; Carbohydrate Metabolism - citrate (TCA) cycle; Carbohydrate Metabolism - glycolysis and gluconeogenesis; Carbohydrate Metabolism - pyruvate; EC 1.2.4.1; Mitochondrial; Oxidoreductase P08559 5160 Xp22.12 human S239-p 1870773102 SVERAAAsTDYYKRG E1_dh enzymatic activity, inhibited carcinogenesis, induced 32993545 1 0 0 +MEF2A MEF2A DNA-binding; Motility/polarity/chemotaxis; Transcription factor Q02078 4205 15q26.3 human T312-p 448097 QATQPLAtPVVSVTT activity, induced transcription, altered 10849446; 9858528 3 0 0 +Ahcyl1 AHCYL1 Amino Acid Metabolism - cysteine and methionine; EC 3.3.1.1; Hydrolase; Other Amino Acids Metabolism - selenoamino acid Q80SW1 229709 3 F2.3|3 46.83 cM mouse S71-p 467245 SRSISQSsTDSYSSA molecular association, regulation PIP4K2A(INDUCES); PIP5K1A(INDUCES); IP3R1(INDUCES) 16793548; 26509711 5 1 0 +Tie1 TIE1 EC 2.7.10.1; KINASE; Kinase, protein; Membrane protein, integral; Protein kinase, TK; Protein kinase, tyrosine (receptor) Q06806 21846 4 D2.1|4 54.67 cM mouse T794-p 50596802 LHRRRTFtYQSGSGE molecular association, regulation RAC1(INDUCES) 26436659 1 0 0 angiogenesis and vascular morphogenesis +SREBF1 SREBP-1 DNA-binding; Membrane protein, integral; Membrane protein, multi-pass; Transcription factor P36956 6720 17p11.2 human K324-ac 459100 SAQSRGEkRTAHNAI HLH protein stabilization; ubiquitination transcription, induced 12640139; 20595232 2 0 0 +Tp53 p53 Activator; DNA-binding; Motility/polarity/chemotaxis; Nuclear receptor co-regulator; Transcription factor; Tumor suppressor P02340 22059 11 B3|11 42.83 cM mouse S180-p 18675301 CPHHERCsDGDGLAP P53 molecular association, regulation cell growth, induced; transcription, inhibited DNA(DISRUPTS) 32873634 3 1 0 induced lymphomagenesis +FLI1 FLI1 DNA-binding; Oncoprotein; Transcription factor Q01543 2313 11q24.3 human K252-ac 28108001 GGAQTISkNTEQRPQ transcription, induced 22973553 1 1 0 +AURKB AurB EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, Other; Protein kinase, Ser/Thr (non-receptor) Q96GD4 9212 17p13.1 human T236-p 4164705 RRKTMCGtLDYLPPE Pkinase protein conformation; phosphorylation; enzymatic activity, induced cell cycle regulation; cytoskeletal reorganization 31819079; 34635673 2 5 16 primes autophosphorylation of itself and phosphorylation of Hec1; required for spindle assembly checkpoint +Pard3 PAR3-alpha Adaptor/scaffold; Motility/polarity/chemotaxis Q9Z340 81918 19q12 rat T833-p 2512944 QSMSEKRtKQFSNAS protein degradation; molecular association, regulation cell motility, altered; cytoskeletal reorganization PARD6A(DISRUPTS); PKCI(DISRUPTS); PKCA(DISRUPTS) 18267089; 28319357 3 0 0 +Casp4 CASP4 Apoptosis; EC 3.4.22.64; Protease P70343 12363 9 A1|9 2.46 cM mouse K312-ub 1877676801 HHLSYRDkTGGSYFI Peptidase_C14 protein degradation 30816303 1 0 0 +CIC capicua DNA-binding; Transcription factor Q96RK0 23152 19q13.2 human S301-p 478739 ETRERSMsETGTAAA molecular association, regulation; intracellular localization transcription, induced 14-3-3 theta(INDUCES) 33103082 1 4 29 +RAF1 RAF1 EC 2.7.11.1; KINASE; Kinase, protein; Oncoprotein; Protein kinase, Ser/Thr (non-receptor); Protein kinase, TKL P04049 5894 3p25.2 human S43-p 447744 FGYQRRAsDDGKLTD molecular association, regulation; intracellular localization; enzymatic activity, inhibited 14-3-3 beta(INDUCES); HRas(DISRUPTS) 12801936; 15664191; 7935389 17 23 5 +PKN1 PKN1 EC 2.7.11.13; KINASE; Kinase, protein; Protein kinase, AGC; Protein kinase, Ser/Thr (non-receptor) Q16512 5585 19p13.12 human S562-p 483683 LGTDSDSsPQKSSRD enzymatic activity, induced carcinogenesis, induced; cell motility, induced; cell growth, induced 31981797 1 30 2 induces anchorage-independent cell growth +WAS WASP Adaptor/scaffold; Motility/polarity/chemotaxis P42768 7454 Xp11.23 human S484-p 449295 RSRAIHSsDEGEDQA molecular association, regulation cytoskeletal reorganization ARPC3(INDUCES) 12769847 2 11 0 The double mutant (S483A/S484A) was used in this study. +DDX3X DDX3 Cell cycle regulation; EC 3.6.4.13; Helicase; RNA-binding; Spliceosome; Translation initiation O00571 1654 Xp11.4 human T204-p 457783 LTRYTRPtPVQKHAI DEAD enzymatic activity, inhibited translation, altered; cell growth, altered 16280325; 17379183 2 2 0 +IRF3 IRF3 DNA-binding; Transcription factor Q14653 3661 19q13.33 human K39-ub 1877340001 TRFRIPWkHGLRQDA IRF protein degradation; molecular association, regulation autophagy, induced; transcription, induced CALCOCO2(INDUCES) DNA(INDUCES) 32075857; 37330913 2 0 0 GPR108 and Smurf1 mediated degradation requires NDP52; NDP52-dependent autophagic degradation of phosphorylated IRF3; GPR108 interacts with Smurf1, followed by the recruitment of IRF3 during viral infection +TAGLN2 TAGLN2 Cytoskeletal; Motility/polarity/chemotaxis P37802 8407 1q23.2 human S83-p 19083400 PVKKIQAsTMAFKQM CH molecular association, regulation carcinogenesis, induced; cell motility, induced; cytoskeletal reorganization ACTB(DISRUPTS) 21577206 1 2 0 +Foxp3 FOXP3 C2H2-type zinc finger protein; Cell cycle regulation; DNA-binding; Transcription factor Q99JB6 20371 X A1.1|X 3.41 cM mouse K267-ac 25614401 AGKMALAkAPSVASM protein stabilization; ubiquitination cell differentiation, induced 22312127 3 1 0 inhibits ubiquitination +USP16 USP16 DEUBIQUITINASE; EC 3.4.19.12; Protease; Ubiquitin conjugating system; Ubiquitin-specific protease Q9Y5T5 10600 21q21.3 human S486-p 50592105 SEYEAEMsLQGEVNI UCH enzymatic activity, induced 26323689 1 1 0 +DPYSL2 CRMP-2 Microtubule-binding; Motility/polarity/chemotaxis Q16555 1808 8p21.2 human T555-p 448084 DNIPRRTtQRIVAPP molecular association, regulation; intracellular localization; protein conformation; phosphorylation cytoskeletal reorganization TUBA1A(DISRUPTS); KLC1(DISRUPTS) 21421798; 22443207; 29926835; 32019603 19 2 8 +Cdh5 CDH5 Cell adhesion; Membrane protein, integral; Motility/polarity/chemotaxis P55284 12562 8 D3|8 53.04 cM mouse Y645-p 2028403 IHEQLVTyDEEGGGE cell motility, altered 18096689 1 0 0 affects cell migration and increased endothelial cell barrier permeability +HNRNPC hnRNP C1/C2 RNA splicing; RNA-binding; Spliceosome P07910 3183 14q11.2 human S253-p 448835 ETNVKMEsEGGADDS molecular association, regulation RNA(NOT_REPORTED) 15687492 2 45 17 +MEF2C MEF2C iso3 DNA-binding; Transcription factor Q06413-3 4208 5q14.3 human S59-p 447999 NKLFQYAsTDMDKVL transcription, induced 26660426 2 0 0 IEG genes during preBCR signaling +TPPP TPPP Cytoskeletal O94811 11076 5p15.33 human S160-p 487536 GVTKAISsPTVSRLT p25-alpha cytoskeletal reorganization 17693641 1 11 0 ERK2 phosphorylation of TPPP induces formation of tubulin assemblies. +Fos Fos DNA-binding; Motility/polarity/chemotaxis; Oncoprotein; Transcription factor P12841 314322 6q31 rat T325-p 448483 TELEPLCtPVVTCTP activity, induced; molecular association, regulation transcription, altered DNA(INDUCES) 17223854 5 0 1 +PPARG PPAR-gamma DNA-binding; Nuclear receptor; Transcription factor P37231 5468 3p25.2 human S273-p 15175800 TGKTTDKsPFVIYDM carcinogenesis, induced; apoptosis, inhibited; transcription, induced; transcription, altered; transcription, inhibited 26670611; 26740599; 36214635; 36841479 26 2 0 +P2rx3 P2X3 Channel, ligand-gated; Membrane protein, integral; Membrane protein, multi-pass P49654 81739 3q24 rat Y393-p 9486200 QSTDSGAySIGH___ activity, inhibited 19509283 1 0 0 +APC APC Motility/polarity/chemotaxis; Tumor suppressor P25054 324 5q22.2 human S2034-p 454100 LSSLSIDsEDDLLQE SAMP intracellular localization 11689703 1 0 0 +ZAP70 ZAP70 EC 2.7.10.2; KINASE; Kinase, protein; Protein kinase, TK; Protein kinase, tyrosine (non-receptor) P43403 7535 2q11.2 human T293-p 478058 TLNSDGYtPEPARIT molecular association, regulation; activity, inhibited CD3Z(INDUCES) 29440413 1 2 10 negatively regulates signals and functional responses downstream of the TCR +Stmn2 STMN2 Cytoskeletal P55821 20257 3 A1|3 2.15 cM mouse S73-p 450173 EAPRTLAsPKKKDLS Stathmin protein degradation; activity, inhibited cell motility, altered; cytoskeletal reorganization 16618812; 21297631; 24469251 9 1 0 Phosphorylated SCG10 accumulates in THC-treated neurons after proteasomal inhibition.; phospho-mimetic S62D/S73D mutant stabilizes microtubules; inhibits microtubule depolymerization activity of STMN2 (SCG10). +IRS4 IRS4 Adaptor/scaffold O14654 8471 Xq22.3 human Y656-p 1877150800 SGGRFRLyFCVDRGA cell cycle regulation; carcinogenesis, induced; cell growth, induced 35550247 1 1 0 +CUL3 CUL3 Cell cycle regulation; UBIQUITIN LIGASE; Ubiquitin conjugating system; Ubiquitin ligase Q13618 8452 2q36.2 human K712-ne 486343 AAIVRIMkSRKKMQH Cullin_Nedd8 molecular association, regulation; ubiquitination KEAP1(INDUCES); RBX1(INDUCES); CAND1(INDUCES) 16449638 1 1 0 Neddylation of Cul3 is required for Keap1-dependent ubiquitination of Nrf2 in vivo, but not in vitro. +Clcn3 CLCN3 iso2 Channel, chloride; Membrane protein, integral; Membrane protein, multi-pass; Transporter; Transporter, ion channel; Vesicle P51792-2 84360 rat Y284-p 3577859 FSLEEVSyYFPLKTL Voltage_CLC activity, induced; molecular association, regulation apoptosis, inhibited; signaling pathway regulation ITGB3(INDUCES) 23536605; 24611720; 25537517 3 0 0 channel activation; Integrin ?3/Src/ClC-3 +EIF5 EIF5 Translation; Translation initiation P55010 1983 14q32.32 human S390-p 448030 KEAEEESsGGEEEDE W2 molecular association, regulation cell cycle regulation; translation, altered eIF2-alpha(INDUCES) 16227438; 18649047 3 53 44 +H3C1 H3 DNA-binding P68431 8350 6p22.2 human K4-m2 459004 ____ARTkQTARKST Histone molecular association, regulation; acetylation; methylation; intracellular localization cell cycle regulation; carcinogenesis, inhibited; apoptosis, induced; cell growth, inhibited; transcription, induced; transcription, altered; signaling pathway regulation; DNA repair, induced; cell differentiation, induced; chromatin organization, altered; cell growth, induced; transcription, inhibited CDC73(INDUCES); PHF23(INDUCES); PHF2(INDUCES); WDR5(INDUCES); PHF12(INDUCES); RBBP4(DISRUPTS); FALZ(INDUCES); ING4(INDUCES); TIF1G(INDUCES); CHD-7(INDUCES); SH2BP1(INDUCES); PHF21A(INDUCES); JADE3(INDUCES); MLL(INDUCES); CCDC101(INDUCES); RBBP5(INDUCES); PHF8(INDUCES); PAF(INDUCES); FALZ iso4(INDUCES); PHF14(INDUCES); RAI1(INDUCES); CHD-1(INDUCES) 15620353; 16728976; 17305432; 17310985; 17351631; 17363312; 17567990; 17636034; 17968314; 18701507; 19021773; 19187765; 19229332; 19251738; 19337993; 19460472; 19473514; 19717977; 19805358; 19885928; 19889207; 19935671; 20033197; 20043883; 20228790; 20404096; 20452361; 20473313; 20484083; 20546607; 20548336; 20850016; 20959362; 23285160; 23302691; 34853474; 35409160 108 10 0 expression of genes in clusters 8 and 9 by cooperating with H4K16ac, H3K4me2, and H3K4me3 at the transcription start sites (TSSs); H1 linker histone inhibits H3K4 dimethylation and promotes epigenetic silencing; promotes centromeric transcription and increased R-loop formation in response to DSBs; HR factors recruitment at centromeric DSBs in G1 and G2 +NFE2L2 NRF2 DNA-binding; Transcription factor Q16236 4780 2q31.2 human K543-ac 7106315 KEKLLKEkGENDKSL bZIP_Maf molecular association, regulation transcription, induced DNA(INDUCES) 19273602 1 1 0 +PTEN PTEN Carbohydrate Metabolism - inositol phosphate; EC 3.1.3.16; EC 3.1.3.48; EC 3.1.3.67; Motility/polarity/chemotaxis; Nuclear receptor co-regulator; PHOSPHATASE; Phosphatase, lipid; Tumor suppressor P60484 5728 10q23.31 human K289-sm 27490410 GPEETSEkVENGSLC PTEN_C2 molecular association, regulation; ubiquitination; intracellular localization ubiquitin(DISRUPTS) 23013792 1 0 0 SUMO 1 modification inhibits ubiquitination +MYH7 MYH7 Motility/polarity/chemotaxis; Motor P12883 4625 14q11.2 human K429-ac 1881951901 YATGALAkAVYERMF protein conformation 35502901 0 1 0 +MAPT Tau iso8 ACETYLTRANSFERASE; Acetyltransferase; Cytoskeletal P10636-8 4137 17q21.31 human K290-ac 1881568101 DLSNVQSkCGSKDNI molecular association, regulation 34426645 1 0 0 reduced tau microtuble interactions +Twist1 TWIST1 Cell development/differentiation; DNA-binding; Inhibitor; Transcription regulation P26687 22160 12 A3|12 14.81 cM mouse S127-p 14821303 RERQRTQsLNEAFAA HLH cell motility, induced; cell growth, induced 25622896 5 1 0 invasion in prostate cancer cells, cancer metastasis in vivo +UBA52-RPS27A-UBB-UBC ubiquitin Ubiquitin-like modifier P62988 2p16 human K33-ub 486302 VKAKIQDkEGIPPDQ ubiquitin molecular association, regulation; ubiquitination; intracellular localization autophagy, induced LC3B(INDUCES); TBK1(INDUCES) 33975961; 35474067; 36379251 10 15 135 BAP37 promotes ef?cient mitophagy ; downregulation by HIV-1 Nef, required for SERINC5 anti-HIV-1 activity; interaction between TRAF3 and Avibirnavirus VP3 was enhanced in KEK293T cells overexpressing K33 ubiquitin, TRAF3 K154 is necessary for VP3 to downregulate IFN-beta production +KDM5A JARID1A DEMETHYLASE; Demethylase; EC 1.14.11.-; Nuclear receptor co-regulator; Nucleolus; Oxidoreductase; Transcription factor P29375 5927 12p13.33 human T285-p 56630501 QMRQRKGtLSVNFVD intracellular localization 27292631 1 0 0 JARID1A recruitment to the promoters of AKT-regulated genes +BRCA2 BRCA2 DNA repair, damage; Nuclear receptor co-regulator; Tumor suppressor P51587 675 13q13.1 human T207-p 469578 TPPTLSStVLIVRNE molecular association, regulation; phosphorylation cell cycle regulation; cell growth, induced PPP2CA(INDUCES); BUB1(INDUCES); PLK1(INDUCES) 32286328 2 1 0 causes self priming of its phosphorylation +HNRNPC hnRNP C1/C2 RNA splicing; RNA-binding; Spliceosome P07910 3183 14q11.2 human Y57-p 2811401 KGFAFVQyVNERNAR RRM_1 molecular association, regulation RNA(INDUCES) 18494499 1 2 1 Northwestern analysis, RNA stabilization +ZBTB16 PLZF C2H2-type zinc finger protein; DNA-binding; Oncoprotein; Transcription, coactivator/corepressor Q05516 7704 11q23.2 human S197-p 2134715 SFGLSAMsPTKAAVD protein degradation cell cycle regulation; transcription, altered; cell growth, altered 18246121 1 0 0 +GLI1 GLI1 C2H2-type zinc finger protein; Oncoprotein; Transcription factor P08151 2735 12q13.3 human S408-p 41595600 GPLPRAPsISTVEPK protein degradation; molecular association, regulation; ubiquitination; intracellular localization; activity, inhibited carcinogenesis, inhibited; cell growth, inhibited; transcription, inhibited BTRC(INDUCES) 26190112; 26843621; 28562331 4 2 0 +SYK Syk EC 2.7.10.2; KINASE; Kinase, protein; Protein kinase, TK; Protein kinase, tyrosine (non-receptor) P43405 6850 9q22.2 human K375-ub 1881478400 KLLTLEDkELGSGNF molecular association, regulation; intracellular localization; protein conformation; enzymatic activity, induced SHP-1(DISRUPTS) 34362877 1 1 0 TRIM31 attenuated SHP-1 mediated WT SYK dephosphorylation; anti-fungal responses; SYK translocation to the membrane and binding with the C-type lectin receptors (CLRs) +MUS81 MUS81 Deoxyribonuclease; EC 3.1.22.-; Nucleolus Q96NY9 80198 11q13.1 human K524-sm 1872852106 ETLLSTIkCGRLQRN cell cycle regulation; DNA repair, induced 28318385 1 0 0 regulates genomic stability and chromosome alignment +Dlg1 DLG1 Adaptor/scaffold; Motility/polarity/chemotaxis Q62696 25252 11q22 rat S232-p 451615 ITLERGNsGLGFSIA PDZ molecular association, regulation neural plasticity NMDAR2A(DISRUPTS) 12933808; 17156128; 35977502 4 4 0 +GLI3 GLI3 C2H2-type zinc finger protein; Transcription factor P10071 2737 7p14.1 human K436-m1 56418600 PMHNKRSkIKPDEDL protein stabilization cell growth, induced 27146893 1 1 0 positively regulates tumorigenesis in NSCLCs +ORAI1 ORAI1 Channel, calcium; Membrane protein, integral; Membrane protein, multi-pass Q96D31 84876 12q24.31 human S30-p 14932000 TTSGSRRsRRRSGDG activity, induced; molecular association, regulation; intracellular localization; activity, inhibited cell growth, inhibited; cell motility, inhibited IP3R2(INDUCES) 20534587; 23144458; 31652779; 35805121 5 0 0 +Grm5 mGluR5 GPCR, family 3; Membrane protein, integral; Membrane protein, multi-pass; Receptor, GPCR Q3UVX5 108071 7|7 D3 mouse S870-p 25745197 NLWKRRGsSGETLRY signaling pathway regulation 25639954 1 1 1 required for activation of ERK signaling and intracellular Ca2+ oscillations +RET Ret EC 2.7.10.1; KINASE; Kinase, protein; Membrane protein, integral; Oncoprotein; Protein kinase, TK; Protein kinase, tyrosine (receptor) P07949 5979 10q11.21 human T675-p 22553316 PISSAEMtFRRPAQA intracellular localization signaling pathway regulation 22128160 1 0 0 modulates GDNF-induced downstream signaling and cell differentiation +Maf MAF Cell development/differentiation; DNA-binding; Oncoprotein; Transcription factor; Tumor suppressor P54843 17132 8 E1|8 62.61 cM mouse Y92-p 25673105 KAHLEDYyWMTGYPQ Maf_N molecular association, regulation transcription, induced DNA(INDUCES) 25993510 2 0 0 IL-4 and IL-21 induction +Tp53 p53 Activator; DNA-binding; Motility/polarity/chemotaxis; Nuclear receptor co-regulator; Transcription factor; Tumor suppressor P02340 22059 11 B3|11 42.83 cM mouse K161-ac 2793003 VRAMAIYkKSQHMTE P53 cell cycle regulation; carcinogenesis, inhibited; apoptosis, induced; transcription, induced 33303641; 33789902 12 1 0 recruit p300, CBP, and TIP60 onto PD-1 promoter, p53-mediated PD-1 transcription; senescence, ferroptosis, failed to develop early-onset tumors +PDGFRA PDGFRA EC 2.7.10.1; KINASE; Kinase, protein; Membrane protein, integral; Oncoprotein; Protein kinase, TK; Protein kinase, tyrosine (receptor) P16234 5156 4q12 human Y720-p 452056 ADESTRSyVILSFEN PK_Tyr_Ser-Thr molecular association, regulation SHP-2(INDUCES) 11818394; 11896619; 8943348 6 3 2 Grb2 binds to the PDGFRalpha indirectly via tyrosine-phosphorylated SHP-2. +FERMT2 kindlin-2 Cytoskeletal; Motility/polarity/chemotaxis Q96AC1 10979 14q22.1 human S159-p 3208605 KKKLDDQsEDEALEL carcinogenesis, induced; cytoskeletal reorganization 25646088; 32104508 2 37 5 regulates invadopodia formation; induces invadopodia formation +CCP110 CP110 Cell cycle regulation O43303 9738 16p12.3 human S400-p 4744475 PINACELsPKGKEQA intracellular localization cell cycle regulation 12361598 1 10 36 +MYO3A MYO3A Actin-binding; EC 2.7.11.1; KINASE; Kinase, protein; Motor; Protein kinase, STE; Protein kinase, Ser/Thr (non-receptor) Q8NEV4 53904 10p12.1 human T178-p 23252211 VSAQLTStRHRRNTS Pkinase enzymatic activity, induced 24214986; 25402663 2 2 1 +TPM1 TPM1 Actin-binding; Motility/polarity/chemotaxis; Motor P09493 7168 15q22.2 human S61-p 456510 EDELDKYsEALKDAQ Tropomyosin intracellular localization 16094730 1 5 6 phosphorylation of site is critical for agonist-stimulated beta-adrenergic receptor endocytosis. +CFLAR CFLAR iso2 Apoptosis O15519-2 8837 2q33.1 human S193-p 7590803 LQAAIQKsLKDPSNN protein stabilization; ubiquitination 19343040 1 2 0 +FBXW7 FBXW7 Motility/polarity/chemotaxis; Nucleolus; UBIQUITIN LIGASE; Ubiquitin conjugating system; Ubiquitin ligase Q969H0 55294 4q31.3 human S176-p 25126709 KRKLDHGsEVRSFSL protein degradation; molecular association, regulation cytoskeletal reorganization Myc(INDUCES) 22399798; 34992218 2 1 0 Phosphorylation prevents ubiquitin-dependent degradation of cyclin E and subsequent centriole duplication. +MAT2A MAT2A Amino Acid Metabolism - cysteine and methionine; EC 2.5.1.6; Other Amino Acids Metabolism - selenoamino acid; Transferase P31153 4144 2p11.2 human K368-sm 50455001 VRDLDLKkPIYQRTA S-AdoMet_synt_C protein stabilization; molecular association, regulation cell growth, induced; apoptosis, inhibited; transcription, induced Bcl-2(INDUCES) DNA(INDUCES) 26416353 1 0 0 +FOXO4 FOXO4 DNA-binding; Oncoprotein; Transcription factor P98177 4303 Xq13.1 human S197-p 448516 APRRRAAsMDSSSKL intracellular localization apoptosis, altered; transcription, inhibited 10217147; 11313479; 16272144; 18794113 13 5 6 +Stx1a STX1A Membrane protein, integral; Vesicle P32851 116470 12q12 rat S14-p 451261 ELRTAKDsDDDDDVT molecular association, regulation exocytosis, altered; signaling pathway regulation; endocytosis, inhibited SNAP-25(INDUCES) 10844023; 21187092; 30411139; 32852799 7 22 4 +FYN Fyn EC 2.7.10.2; KINASE; Kinase, protein; Oncoprotein; Protein kinase, TK; Protein kinase, tyrosine (non-receptor) P06241 2534 6q21 human S21-p 1983273 LTEERDGsLNQSSGY intracellular localization; phosphorylation; enzymatic activity, induced cell motility, altered 20658524 1 38 12 +GPR84 GPR84 GPCR, family 1; Membrane protein, integral; Membrane protein, multi-pass; Motility/polarity/chemotaxis; Receptor, GPCR Q9NQS5 53831 12q13.13 human T264-p 1876864000 EPVSAATtQTLEGDS 7tm_1 receptor internalization, induced; molecular association, regulation ARR3(INDUCES); ARRB2(INDUCES) 35427647 1 1 0 +GRK2 GRK2 EC 2.7.11.15; KINASE; Kinase, protein; Protein kinase, AGC; Protein kinase, Ser/Thr (non-receptor) P25098 156 11q13.2 human S29-p 447724 ATPAARAsKKILLPE activity, induced 11042191 2 0 0 +CYCS CYCS Apoptosis; Mitochondrial; Oxidoreductase; PHOSPHATASE; Protein phosphatase, Ser/Thr (non-receptor) P99999 54205 7p15.3 human K54-ac 1968625 YSYTAANkNKGIIWG Cytochrom_C molecular association, regulation; enzymatic activity, inhibited; protein conformation apoptosis, inhibited 33916826; 34455704 2 2 0 reduced cytochrome c oxidase and caspase 3 activity, reduced cardiolipin peroxidase activity, reduced oxygen consumption with acetylmimetic Cytc as compared to WT, increased ROS scavenging ; loss of positive potential at the surface areas around the mutated residue, thermal stability of Cc species is slightly changed, local structural changes, and increased binding afinity for the Cc1-Cc complex for the K8 mutants +Ces1d CES1D EC 3.1.1.1; EC 3.1.1.67 P16303 113902 19p11 rat N506-p 3540200 ANFARNGnPNGGGLP COesterase enzymatic activity, induced 11429416 2 0 0 mutation to serine selectively stimulated hydrolysis but was not sufficient to confer cholesteryl esterase activity. +Skap2 SKAP2 Adaptor/scaffold Q3UND0 54353 6|6 B3 mouse Y260-p 449668 QPIDDEIyEELPEEE molecular association, regulation cell motility, induced; cell growth, altered LYN(INDUCES); Hck(INDUCES); Fyn(INDUCES) 11063873; 23897807 5 8 100 +Stat3 STAT3 DNA-binding; Motility/polarity/chemotaxis; Nuclear receptor co-regulator; Transcription factor P42227 20848 11 D|11 63.82 cM mouse K370-ac 41519931 KIKVCIDkDSGDVAA STAT_bind molecular association, regulation transcription, induced; signaling pathway regulation NFkB-p65(INDUCES) 28637784 1 1 0 signaling to improve mitochondrial fusion and function; K383 may induce stronger binding, enhanced OPA1 expression +Ctnnd1 CTNND1 Actin-binding; Adaptor/scaffold; Cell adhesion; G protein regulator, misc.; Motility/polarity/chemotaxis P30999 12388 2 D|2 49.45 cM mouse Y280-p 450398 HRFHPEPyGLEDDQR cell cycle regulation; cell motility, altered 18515860 2 18 210 +Actn4 ACTN4 Cytoskeletal; Motility/polarity/chemotaxis P57780 60595 7|7 B1 mouse Y32-p 11498502 GGGSMGDyMAQEDDW cytoskeletal reorganization 33532643 5 1 0 decreased binding to actin filaments has been observed after phosphorylation of this site +STAP2 STAP2 Adaptor/scaffold Q9UGK3 55620 19p13.3 human Y322-p 3974222 GDGPAVDyENQDVAS molecular association, regulation transcription, altered STAT3(INDUCES) 12540842 1 1 6 +ESR1 ER-alpha DNA-binding; Nuclear receptor; Transcription factor P03372 2099 6q25.1-q25.2 human S167-p 448102 GGRERLAsTNDKGSM Oest_recep activity, induced; acetylation; molecular association, regulation; phosphorylation carcinogenesis, induced; cell growth, induced; apoptosis, inhibited; transcription, induced; signaling pathway regulation; transcription, altered; cell growth, altered SRC-3(INDUCES) DNA(NOT_REPORTED) 11108261; 11139588; 11432835; 11507039; 15528270; 15778291; 16455819; 19112174; 19887647; 19940156; 23390529; 23861392; 24166501; 31120927; 33542078; 34810200; 35121200; 36915147; 9337862; 9528769 48 6 0 +PKP1 plakophilin 1 Cell adhesion; Motility/polarity/chemotaxis Q13835 5317 1q32.1 human T166-p 15405306 LYCDPRGtLRKGTLG activity, induced; protein stabilization cell motility, induced; cell growth, induced; translation, induced; cell adhesion, inhibited 23444369 1 2 34 +USP11 USP11 DEUBIQUITINASE; EC 3.4.19.12; Protease; Ubiquitin conjugating system; Ubiquitin-specific protease P51784 8237 Xp11.3 human S948-p 466974 GSSGAPAsPACSSPP ubiquitination; intracellular localization carcinogenesis, induced; cell growth, induced 35414784 1 11 14 induces deubiquitination of p21 +Ahr AHR DNA-binding; Transcription factor P41738 25690 6q16 rat T385-p 3798901 IATQRPLtDEEGREH transcription, altered 15451023 1 0 0 +EMD emerin Cytoskeletal; Membrane protein, integral P50402 2010 Xq28 human S175-p 457527 RPVSASRsSLDLSYY molecular association, regulation BAF(DISRUPTS) 16204256 1 5 0 +BMAL1 BMAL1 DNA-binding; Transcription factor O00327 406 11p15.3 human S183-p 1884110700 VFKILNYsQNDLIGQ molecular association, regulation; intracellular localization carcinogenesis, induced; DNA repair, induced; apoptosis, inhibited CLOCK(INDUCES) 36725890 1 0 0 +Vim Vimentin Cytoskeletal; Motility/polarity/chemotaxis P20152 22352 2 A1|2 10.04 cM mouse S39-p 451766 TTSTRTYsLGSALRP Filament_head intracellular localization cell motility, altered; cytoskeletal reorganization 12458200; 21346197; 35656400 31 52 30 +XRN2 XRN2 Cell development/differentiation; EC 3.1.13.-; Nucleolus; RNA processing; RNA-binding; Ribonuclease Q9H0D6 22803 20p11.22 human T439-p 3211959 FTPSGILtPHALGSR XRN_M molecular association, regulation; enzymatic activity, induced transcription, inhibited DNA(INDUCES) 26728557 2 16 7 +LRRK2 LRRK2 EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, Ser/Thr (non-receptor); Protein kinase, TKL Q5S007 120892 12q12 human T1348-p 10426320 GNTGSGKtTLLQQLM Roc molecular association, regulation; protein conformation 21806997; 21858031 5 3 0 induces protein destabilization due to unfavourable conformation; GTP binding, does not play a modulatory role on LRRK2 kinase activity +PRKAA1 AMPKA1 Autophagy; EC 2.7.11.1; EC 2.7.11.26; EC 2.7.11.27; EC 2.7.11.31; KINASE; Kinase, protein; Protein kinase, CAMK; Protein kinase, Ser/Thr (non-receptor) Q13131 5562 5p13.1 human K285-ub 21128824 WFKQDLPkYLFPEDP enzymatic activity, inhibited 31996460 1 2 0 +GP1BA GPIbA Cell adhesion; Cell surface; Membrane protein, integral P07359 2811 17p13.2 human S629-p 1983276 LVAGRRPsALSQGRG molecular association, regulation 14-3-3 sigma(INDUCES); 14-3-3 zeta(INDUCES); PIK3R1(INDUCES) 18299448; 19874472 3 10 17 +SIAH1 SIAH1 Apoptosis; Cell development/differentiation; EC 6.3.2.-; EC 6.3.2.19; Ligase; Motility/polarity/chemotaxis; UBIQUITIN LIGASE; Ubiquitin conjugating system; Ubiquitin ligase Q8IUQ4 6477 16q12.1 human Y126-p 457102 ELCEFRPySCPCPGA Sina protein stabilization apoptosis, altered 16230351 1 0 0 +PSRC1 PSRC1 Q6PGN9 84722 1p13.3 human S22-p 18912817 TLDFGGLsPSDSREE GTSE1_N cytoskeletal reorganization 21473853 1 3 0 +MAPK3 ERK1 EC 2.7.11.24; KINASE; Kinase, protein; Protein kinase, CMGC; Protein kinase, Ser/Thr (non-receptor) P27361 5595 16p11.2 human K361-m3 52477003 DLPKERLkELIFQET enzymatic activity, induced transcription, induced 26586479 1 1 0 SUV420H1 siRNA inhibits ERK expression +Camk2b CAMK2B EC 2.7.11.17; KINASE; Kinase, protein; Protein kinase, CAMK; Protein kinase, Ser/Thr (non-receptor) P28652 12323 11 A1|11 3.89 cM mouse S182-p 18007574 AGTPGYLsPEVLRKE Pkinase enzymatic activity, inhibited 36194579 1 0 1 +RUNX1 AML1 DNA-binding; Oncoprotein; Transcription factor Q01196 861 21q22.12 human T207-p 34551130 ELEQLRRtAMRVSPH molecular association, regulation; methylation; intracellular localization carcinogenesis, induced; transcription, induced HDAC1(DISRUPTS); SIN3A(DISRUPTS); PRMT1(INDUCES) 32549768 1 1 1 induce osteolytic bone destruction +HSF1 HSF1 DNA-binding; Transcription factor Q00613 3297 8q24.3 human S320-p 3849409 ASPGRPSsVDTLLSP Vert_HS_TF activity, induced; protein stabilization; molecular association, regulation; intracellular localization carcinogenesis, induced; apoptosis, inhibited; transcription, induced; transcription, inhibited p300(INDUCES) 21085490; 22216146; 25963659; 31516744; 33268814 8 6 1 +GCK GK Carbohydrate Metabolism - amino sugar and nucleotide sugar; Carbohydrate Metabolism - galactose; Carbohydrate Metabolism - glycolysis and gluconeogenesis; Carbohydrate Metabolism - starch and sucrose; EC 2.7.1.2; Kinase, other; Mitochondrial P35557 2645 7p13 human K161-sm 27581519 VRHEDIDkGILLNWT Hexokinase_1 protein stabilization; enzymatic activity, induced 23297408 1 1 0 +P2ry2 P2Y2 GPCR, family 1; Membrane protein, integral; Membrane protein, multi-pass; Receptor, GPCR; Receptor, misc. P41232 29597 1q32 rat S242-p 2909200 LPRAKRKsVRTIALV 7tm_1 receptor internalization, induced 31289122 2 0 0 Regulates ATP induced calcium response +PGD PGD Carbohydrate Metabolism - pentose phosphate pathway; EC 1.1.1.44; Other Amino Acids Metabolism - glutathione; Oxidoreductase P52209 5226 1p36.22 human Y481-p 465221 GTVSSSSyNA_____ enzymatic activity, induced carcinogenesis, induced; cell growth, induced; transcription, induced 30824700 1 1 45 phosphorylation of this site increases NADP+ binding affinity of 6PGD; required for ROS detoxification and tumor cell survival upon IR treatment ; promotes DNA synthesis +JADE1 JADE1 Tumor suppressor Q6IE81 79960 4q28.2 human S20-p 35530401 SDDNGSLsTTWSQNS EPL1 protein stabilization; activity, inhibited cell differentiation, induced; transcription, induced; signaling pathway regulation 25100726 1 1 0 impairs the ability of Jade-1S to inhibit Wnt reporter activity; Decrease the ability of Jade-1 to inhibit ?-catenin signaling +Irs2 IRS2 Adaptor/scaffold; Motility/polarity/chemotaxis P81122 384783 8 A1.1|8 5.35 cM mouse S924-p 28758700 GEAGTRLsPPAPPLL activity, inhibited 23901139 1 2 0 +KLF8 KLF8 C2H2-type zinc finger protein; DNA-binding; Transcription factor O95600 11279 Xp11.21 human K95-ac 25344506 DLSFHKPkAPLQPAS sumoylation; molecular association, regulation cell cycle regulation; transcription, inhibited CTBP1(DISRUPTS) 21416054 1 1 0 inhibits sumoylation at KLF8-K67 +PRPS2 PRPS2 Carbohydrate Metabolism - pentose phosphate pathway; EC 2.7.6.1; Kinase, other; Nucleotide Metabolism - purine P11908 5634 Xp22.2 human T228-p 1874512700 DMADTCGtICHAADK Pribosyl_synth molecular association, regulation; enzymatic activity, induced DNA repair, induced; cell growth, induced Other(NOT_REPORTED) 34343500 1 1 0 inhibits ADP binding +Cbx5 HP1 alpha Transcription, coactivator/corepressor Q61686 12419 15|15 F3 mouse S12-p 3190486 TKRTADSsSSEDEEE molecular association, regulation H3(INDUCES) DNA(INDUCES) 21245376 1 29 1 important for chromosomal stability +Ctnnd1 CTNND1 Actin-binding; Adaptor/scaffold; Cell adhesion; G protein regulator, misc.; Motility/polarity/chemotaxis P30999 12388 2 D|2 49.45 cM mouse K623-ac 15292745 ASCFGAKkGKDEWFS cytoskeletal reorganization 16916647 0 1 1 +DLX3 DLX3 DNA-binding; Transcription factor O60479 1747 17q21.33 human S10-p 25736077 GSFDRKLsSILTDIS protein stabilization; molecular association, regulation cell differentiation, induced; transcription, induced DNA(INDUCES) 24924519 1 0 1 +IKZF1 Ikaros C2H2-type zinc finger protein; DNA-binding; Transcription factor Q13422 10320 7p12.2 human K58-sm 3609102 RVVASNVkVETQSDE carcinogenesis, induced; cell growth, induced 27315244 2 0 0 +Ptk2b Pyk2 EC 2.7.10.2; KINASE; Kinase, protein; Nuclear receptor co-regulator; Protein kinase, TK; Protein kinase, tyrosine (non-receptor) P70600 50646 15p12 rat Y580-p 447957 YIEDEDYyKASVTRL PK_Tyr_Ser-Thr enzymatic activity, induced 11337490 16 25 970 +Ppp2r5d PPP2R5D Motility/polarity/chemotaxis; PHOSPHATASE; Protein phosphatase, regulatory subunit Q7TNL5 21770 17 22.9 cM|17 C mouse S53-p 457388 PSSNKRPsNSTPPPT enzymatic activity, induced 20106966 5 0 0 +DDIT3 DDIT3 Autophagy; DNA-binding; Oncoprotein; Transcription factor P35638 1649 12q13.3 human S15-p 455502 FSFGTLSsWELEAWY activity, inhibited transcription, inhibited 12876286 1 0 0 +Spi1 PU.1 DNA-binding; Oncoprotein; Transcription factor P17433 20375 2 E1|2 50.44 cM mouse S148-p 455900 QSPPLEVsDGEADGL activity, induced; molecular association, regulation RNA splicing, altered; transcription, induced; transcription, altered IRF4(INDUCES); IRF8(INDUCES); PIP(INDUCES); PU.1(INDUCES); IRF8(NOT_REPORTED); IRF2(INDUCES) DNA(INDUCES) 14966110; 17200120; 20190819; 7797077; 8456286 6 4 0 +MCM4 MCM4 DNA replication; EC 3.6.4.12 P33991 4173 8q11.21 human S32-p 450001 RSEDARSsPSQRRRG activity, inhibited 12714602 2 13 9 +MOB1B MOB1B Activator; Protein kinase, regulatory subunit Q7L9L4 92597 4q13.3 human T35-p 3545001 LLKHAEAtLGSGNLR Mob1_phocein molecular association, regulation; phosphorylation cell cycle regulation; cell growth, altered NDR1(INDUCES); NDR2(INDUCES); LATS1(INDUCES); LATS2(INDUCES) 18328708; 19919647 3 47 34 +MACC1 MACC1 Q6ZN28 346389 7p21.1 human Y695-p 1874020220 KESEKVSyVIKKLKE carcinogenesis, induced; cell motility, induced; cell growth, induced; transcription, induced 34247190 1 1 0 +Ctnnb1 CTNNB1 Actin-binding; Cell adhesion; Motility/polarity/chemotaxis; Nuclear receptor co-regulator; Oncoprotein; Transcription factor Q02248 12387 9 F4|9 72.19 cM mouse S47-p 34606438 TTTAPSLsGKGNPEE intracellular localization cell cycle regulation; cytoskeletal reorganization; signaling pathway regulation PCM-1(INDUCES); CEP290(INDUCES); CEP170(INDUCES); AZI2(INDUCES) 32023461 1 1 1 induces localization of centriolar satellites, induces primary ciliogenesis through the primary ciliogenesis signaling pathway +EGFR EGFR EC 2.7.10.1; KINASE; Kinase, protein; Membrane protein, integral; Oncoprotein; Protein kinase, TK; Protein kinase, tyrosine (receptor) P00533 1956 7p11.2 human S1026-p 451640 PQQGFFSsPSTSRTP activity, inhibited 8360196 1 7 0 +CLTC CLTC Motility/polarity/chemotaxis; Vesicle Q00610 1213 17q23.1 human T606-p 1868832801 ILGNQMFtHYDRAHI Clathrin intracellular localization; phosphorylation cell cycle regulation; carcinogenesis, induced; cell growth, induced 31272276 1 0 0 induces phosphorylation of Kiz +RPS6 S6 Translation P62753 6194 9p22.1 human S236-p 448093 AKRRRLSsLRASTSK activity, induced; molecular association, regulation; enzymatic activity, induced cell cycle regulation; carcinogenesis, induced; carcinogenesis, inhibited; apoptosis, induced; cell motility, induced; signaling pathway regulation; cell growth, induced; apoptosis, inhibited RNA(INDUCES) 17360704; 20008839; 21601007; 21750219; 25738361; 34273354; 34523696; 35596155; 35998013; 36216931; 36409827; 36460969; 36635496; 36715448 239 72 1124 +TNKS TNKS EC 2.4.2.30; Transferase O95271 8658 8p23.1 human T1128-p 21326701 VEEEMQStIREHRDG PARP protein stabilization; intracellular localization; enzymatic activity, induced cell cycle regulation; cell growth, induced 21818122 1 0 0 +POLI POLI DNA repair, damage; EC 2.7.7.7; Transferase Q9UNA4 11201 18q21.2 human K334-ub 21181894 FSEEDSFkKCSSEVE IMS_C protein degradation 26370087 1 3 0 +CHEK1 Chk1 EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, CAMK; Protein kinase, Ser/Thr (non-receptor); Tumor suppressor O14757 1111 11q24.2 human K132-ub 31914110 GITHRDIkPENLLLD Pkinase phosphorylation; enzymatic activity, induced DNA(INDUCES) 32357935 3 3 0 ubiquitination at K132 by TRAF4 is required for phosphorylation and activation, and Chk1 chromatin association +Tcf3 E2A Cell development/differentiation; DNA-binding; Oncoprotein; Transcription factor P15806 21423 10 C1|10 39.72 cM mouse S140-p 455905 LSSPGPLsPSGIKSS molecular association, regulation cell differentiation, altered; transcription, altered MyoD(INDUCES) 15719023 3 9 0 +DAXX DAXX Apoptosis; Nuclear receptor co-regulator; Nucleolus; Transcription, coactivator/corepressor Q9UER7 1616 6p21.32 human K122-ub 11998602 RARSRPAkLYVYINE Daxx phosphorylation apoptosis, induced 19789334 1 0 0 induces JNK phosphorylation/activation +CD274 PD-L1 Membrane protein, integral Q9NZQ7 29126 9p24.1 human T210-p 1874101910 TNEIFYCtFRRLDPE C2-set_2 O-GlcNAc glycosylation; protein stabilization; ubiquitination carcinogenesis, induced 34315872 1 0 0 inhibits ubiquitination +NPM1 NPM1 Nucleolus; Oncoprotein; RNA-binding; Translation P06748 4869 5q35.1 human K257-ac 3284526 KMQASIEkGGSLPKV NPM1-C molecular association, regulation; intracellular localization transcription, altered H3(INDUCES) 19581289 1 6 1 K212/215/229/230/257/267/292R mutant +MC2R MC2R GPCR, family 1; Membrane protein, integral; Membrane protein, multi-pass; Receptor, GPCR Q01718 4158 18p11.21 human S208-p 456021 RSHTRKIsTLPRANM 7tm_1 receptor desensitization, altered 12456795 1 0 0 +SMN1 SMN RNA processing; RNA-binding Q16637 6606 5q13.2 human S31-p 454889 GTGQSDDsDIWDDTA SMN activity, induced; molecular association, regulation; intracellular localization coilin(INDUCES); SMN(INDUCES) 15592453; 20878088; 24602413 3 67 26 +PRKDC DNAPK DNA repair, damage; EC 2.7.11.1; KINASE; Kinase, protein; Nucleolus; Protein kinase, Ser/Thr (non-receptor); Protein kinase, atypical P78527 5591 8q11.21 human S2041-p 33365502 STLSEEMsQFDFSTG DNAPKcs_CC3 molecular association, regulation DNA repair, inhibited DNA(INDUCES) 24687855 1 0 0 induces c-NHEJ, restricts end processing +ZFP36L1 BRF1 Transcription factor Q07352 677 14q24.1 human S334-p 7997096 LPIFSRLsISDD___ activity, induced; protein stabilization cell cycle regulation; carcinogenesis, inhibited; cell growth, inhibited; cell motility, inhibited; RNA stability, inhibited; transcription, inhibited; cell adhesion, inhibited DCP1A(INDUCES) 27708140; 30914800 2 26 3 R9-ZnC S334D (aka BRF1) decreases pro-angiogenic and pro-in?ammatory cytokines, as well as EMT marker; enhances VEGF mRNA decay +LIPE HSL EC 3.1.1.79; Lipase Q05469 3991 19q13.2 human S853-p 448803 IAEPMRRsVSEAALA enzymatic activity, induced 19018281 41 11 2 +Dlx5 DLX5 DNA-binding; Transcription factor P70396 13395 6 A1|6 2.83 cM mouse S34-p 1725302 MHHPSQEsPTLPESS DLL_N transcription, induced 18056716 1 0 0 measured by Osx mRNA levels +SMN1 SMN RNA processing; RNA-binding Q16637 6606 5q13.2 human S4-p 7446258 ____MAMsSGGSGGG molecular association, regulation; intracellular localization coilin(INDUCES) 24602413 2 14 0 +Mef2c MEF2C DNA-binding; Transcription factor Q8CFN5 17260 13 C3|13 43.68 cM mouse S222-p 474086 GYGNPRNsPGLLVSP cell cycle regulation; apoptosis, inhibited 29431698 1 33 1 enhanced maintenance of leukemia stem cells +HSF1 HSF1 DNA-binding; Transcription factor Q00613 3297 8q24.3 human T367-p 469241 RPPSPPPtSTPEKCL Vert_HS_TF transcription, inhibited 25963659 1 8 18 under non-stressed conditions, upon heat shock S to A mutant showed 60% higher luciferase activity +SUPT5H SPT5 RNA-binding; Transcription, coactivator/corepressor O00267 6829 19q13.2 human S782-p 4948434 TPMYGSGsRTPMYGS transcription, induced 10757782 1 1 2 +PTH1R PTHR GPCR, family 2; Membrane protein, integral; Membrane protein, multi-pass; Receptor, GPCR Q03431 5745 3p21.31 human S492-p 2853102 RKARSGSsSYSYGPM receptor internalization, induced; molecular association, regulation ARR3(INDUCES) 27623777 4 2 1 S503 AND T504 IN THE SECOND CLUSTER ARE RESPONSIBLE FOR 70% OF ARRESTIN3 RECRUITMENT +LOC100009479 Kv1.2 Channel, potassium; Membrane protein, integral; Membrane protein, multi-pass NP_001076191 100009479 rabbit S449-p 1818102 PDLKKSRsASTISKS activity, induced 19389710 2 3 1 +MAPT Tau iso8 ACETYLTRANSFERASE; Acetyltransferase; Cytoskeletal P10636-8 4137 17q21.31 human T245-p 487534 SAKSRLQtAPVPMPD Tubulin-binding molecular association, regulation 21204788 3 2 0 in vitro microtubule binding +RBL1 Rb-like 1 Transcription, coactivator/corepressor; Tumor suppressor P28749 5933 20q11.23 human S650-p 455534 SVHERYSsPTAGSAK molecular association, regulation E2F4(DISRUPTS) 12006580 3 3 1 +BLM BLM DNA repair, damage; DNA replication; EC 3.6.4.12; Helicase P54132 641 15q26.1 human T122-p 450959 PKEVVCTtQNTPTVK BLM_N protein conformation cell cycle regulation; apoptosis, inhibited 12034743; 14729972; 16880735 5 1 0 In cells expressing BLM T99A/T122A after HU release, entrance into G1 phase was delayed, with p-Chk-1 levels remaining elevated. ; radiosensitivity +Cttn Cortactin Actin-binding; Cytoskeletal; Motility/polarity/chemotaxis Q60598 13043 7|7 F5 mouse K171-ac 15291781 VQADRVDkSAVGFDY HS1_rep molecular association, regulation; acetylation; intracellular localization DIP2A(INDUCES) 31600191 1 0 2 DIP2A regulates spine morphology and synaptic transmission through acetylation of cortactin; Interaction of DIP2A-cortactin is required for acetylated cortactin; acetylation mimetic cortactin rescues the repetitive behaviors in Dip2a KO mice; acetylation alleviated abnormal PSD95 clustering at the spine head in DIP2A KO neurons +CLDN7 Claudin-7 Cell adhesion; Membrane protein, integral; Membrane protein, multi-pass O95471 1366 17p13.1 human S204-p 27732000 VPRSYPKsNSSKEYV apoptosis, induced 23433123 1 1 0 increased sensitivity to cisplatin +Fosb FosB DNA-binding; Transcription factor P13346 14282 7 A3|7 9.56 cM mouse S27-p 465535 SAESQYLsSVDSFGS protein stabilization neural plasticity 19041372; 23467346 4 1 0 +Ptpn1 PTP1B EC 3.1.3.48; Motility/polarity/chemotaxis; PHOSPHATASE; Phosphatase; Protein phosphatase, tyrosine (non-receptor) P35821 19246 2|2 H3 mouse S50-p 447811 RNRYRDVsPFDHSRI Y_phosphatase phosphorylation; enzymatic activity, induced carcinogenesis, induced; apoptosis, inhibited 37000627 5 18 17 dephosphorylates CD3Z +Polr2a POLR2A EC 2.7.7.48; EC 2.7.7.6; Nucleotide Metabolism - purine; Nucleotide Metabolism - pyrimidine; Transcription initiation complex; Transferase P08775 20020 11 B3|11 42.86 cM mouse S1619-p 447616 SPSYSPTsPSYSPTS RNA_pol_Rpb1_R protein degradation; molecular association, regulation; ubiquitination; intracellular localization; enzymatic activity, inhibited; phosphorylation; enzymatic activity, induced transcription, induced; transcription, altered SETD1B(INDUCES); SETD2(INDUCES); SETD1A(INDUCES); TCEB3(INDUCES) 17535807; 18037880; 19037258; 21385826; 21639898; 28423325; 28768201 81 4 0 S1619 phosphorylation of the CTD at the beginning of activation; deletion of MNAT reduces S1619 phosphorylation and defective capping and reduced S1616 phosphorylation and defect in Pol II transcription; low level transcription of bivalent genes +AGER RAGE Cell cycle regulation; Membrane protein, integral; Motility/polarity/chemotaxis; Receptor, misc. Q15109 177 6p21.32 human K374-ub 1873037702 QRRGEERkAPENQEE protein degradation; phosphorylation 28515150 1 0 0 degradation by RAGE phosphorylation by PKCZ and FBXO10-directed ubiquitination +STK38 NDR1 EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, AGC; Protein kinase, Ser/Thr (non-receptor) Q15208 11329 6p21.31 human T282-p 4767540 RRQLAFStVGTPDYI Pkinase activity, induced signaling pathway regulation 31679687 1 0 12 in glucose starvation +KIF2B KIF2B Microtubule-binding; Motor Q8N4N8 84643 17q22 human S616-p 25247526 TTISGKGsSQWLENI intracellular localization cell cycle regulation 22535524 1 1 0 +Casp4 CASP4 Apoptosis; EC 3.4.22.64; Protease P70343 12363 9 A1|9 2.46 cM mouse K172-ub 1877676804 LGYDVVVkEELTAEG Peptidase_C14 protein degradation 30816303 1 0 0 +ITGB3 ITGB3 Cell adhesion; Membrane protein, integral; Motility/polarity/chemotaxis P05106 3690 17q21.32 human Y773-p 448012 DTANNPLyKEATSTF Integrin_b_cyt activity, induced; molecular association, regulation; intracellular localization; protein processing; protein conformation; activity, inhibited cell adhesion, induced; cell motility, altered; cytoskeletal reorganization; cell adhesion, altered Pyk2(INDUCES); GRB2(INDUCES); PVR(DISRUPTS); talin 1(DISRUPTS); tensin 1 iso1(INDUCES); DOK1(INDUCES); VAV1(INDUCES) 10330414; 11723131; 14996908; 15695828; 15699036; 16935858; 17473008; 18156175; 18364349; 21956114; 8631894 22 10 95 +MYH10 MYH10 Motility/polarity/chemotaxis; Motor P35580 4628 17p13.1 human T1847-p 1874404500 ANKLVRRtEKKLKEI Myosin_tail_1 molecular association, regulation; intracellular localization cell cycle regulation MYH10(DISRUPTS); Survivin(DISRUPTS) 34343568 1 0 0 +PGR PR DNA-binding; Nuclear receptor; Transcription factor P06401 5241 11q22.1 human S102-p 450158 GAGGSSSsPPEKDSG Prog_receptor transcription, induced 8662865 2 1 0 +DPYSL2 CRMP-2 Microtubule-binding; Motility/polarity/chemotaxis Q16555 1808 8p21.2 human Y479-p 18833900 KPFPDFVyKRIKARS molecular association, regulation cell motility, altered; cytoskeletal reorganization 19276087; 29396402 4 1 0 regulates T cell polarization and migration; signi?cantly impair the microtubule bundling activity of CRMP2, impaired binding to microtubules +TUBG1 TUBG1 Cytoskeletal; Motility/polarity/chemotaxis P23258 7283 17q21.2 human Y443-p 1876567500 HAATRPDyISWGTQE molecular association, regulation cytoskeletal reorganization GCP5(INDUCES) 35231444 1 1 0 +Rps6 S6 Translation P62754 20104 4|4 C4 mouse S247-p 448096 STSKSESsQK_____ carcinogenesis, induced; transcription, induced; transcription, altered 23361300; 34344824; 34819370 7 24 302 +Traf2 TRAF2 Autophagy; EC 6.3.2.-; Ligase; UBIQUITIN LIGASE; Ubiquitin conjugating system; Ubiquitin ligase P39429 22030 2|2 A3 mouse T117-p 471341 DGCTWKGtLKEYESC molecular association, regulation; ubiquitination; phosphorylation transcription, induced IKKA(INDUCES); IKKB(INDUCES) 19150425 2 0 0 induces IKB phosphorylation +Ezh2 EZH2 EC 2.1.1.43; METHYLTRANSFERASE; Methyltransferase; Methyltransferase, protein lysine Q61188 14056 6 B2.3|6 22.92 cM mouse T487-p 452848 VPTEDVDtPPRKKKR protein degradation 30305391 14 59 66 +DIXDC1 DIXDC1 Cell adhesion; Cell development/differentiation Q155Q3 85458 11q23.1 human S592-p 23099075 SKLPHSQsSPTVSST cytoskeletal reorganization 27829159 1 2 2 regulates microtubule network, dendritic spine growth +Rrad RRAD G protein; G protein, monomeric; G protein, monomeric, RGK NP_445790 83521 19p14 rat S300-p 4700229 AFRAKSKsCHDLSVL activity, induced 36215501 3 17 0 induces CaV1.2 activity +STXBP3 STXBP3 Vesicle O00186 6814 1p13.3 human Y521-p 459181 RQKPRANyLEDRKNG Sec1 molecular association, regulation; intracellular localization 24469400 5 8 68 molecular switch for SNARE complex formation ; localization to the plasma membrane +FLCN FLCN Tumor suppressor Q8NFG4 201163 17p11.2 human S537-p 23107124 EDTQKLLsILGASEE Folliculin_C molecular association, regulation FNIP2(INDUCES); LC3B(DISRUPTS); GABARAP(DISRUPTS) 25126726 1 1 1 +TREML1 TREML1 Immunoglobulin superfamily; Membrane protein, integral Q86YW5 340205 6p21.1 human Y281-p 454865 VCSKPVTyATVIFPG molecular association, regulation signaling pathway regulation SHIP-2(INDUCES) 15128762 2 2 18 enhanced calcium signaling +Xbp1 XBP1 DNA-binding; Transcription factor O35426 22433 11 A1|11 3.61 cM mouse T48-p 21688103 AGSEASGtPQARKRQ intracellular localization transcription, induced 21892182; 34030589 3 0 0 +CDKN1A p21Cip1 Cell cycle regulation; Inhibitor P38936 1026 6p21.2 human K154-ac 12615903 MTDFYHSkRRLIFSK protein stabilization; molecular association, regulation cell cycle regulation; carcinogenesis, inhibited; cell growth, inhibited C8A(DISRUPTS) 20154723 1 0 0 +PTEN PTEN Carbohydrate Metabolism - inositol phosphate; EC 3.1.3.16; EC 3.1.3.48; EC 3.1.3.67; Motility/polarity/chemotaxis; Nuclear receptor co-regulator; PHOSPHATASE; Phosphatase, lipid; Tumor suppressor P60484 5728 10q23.31 human Y315-p 448317 RADNDKEyLVLTLTK PTEN_C2 enzymatic activity, induced cell growth, altered 11948419 3 1 0 +Etv4 ETV4 DNA-binding P28322 18612 11 D|11 65.48 cM mouse K21-ac 26373303 VPYTFCSkSPGNGSL ETS_PEA3_N sumoylation transcription, induced 21543453 1 1 0 acetylated sites inhibits sumoylation reciprocally +SHOC2 SHOC2 Adaptor/scaffold; Protein phosphatase, regulatory subunit Q9UQ13 8036 10q25.2 human T507-p 1867945200 GLGENLLtHLPEEIG LRR_8 protein degradation; molecular association, regulation; ubiquitination; phosphorylation; enzymatic activity, induced cell growth, inhibited; apoptosis, induced; autophagy, inhibited; signaling pathway regulation FBXW7(INDUCES); Raptor(DISRUPTS); ERas(DISRUPTS) 30865892 1 0 0 disrupts binding to Raptor further inducing Raptor binding to mTORC1, induces S6K and 4E-BP1 phosphorylation through mTORC1 activation, inhibits Ras-MAPK signaling +Mcl1 MCL1 Apoptosis; Channel, misc.; Inhibitor; Membrane protein, integral; Mitochondrial P97287 17210 3 F2.1|3 40.74 cM mouse K175-ub 10837355 REQATGSkDSKPLGE protein degradation; molecular association, regulation; ubiquitination autophagy, induced beclin 1(DISRUPTS) 28053206; 32094511 4 5 33 +Cttn Cortactin Actin-binding; Cytoskeletal; Motility/polarity/chemotaxis NP_001385572 60465 1q41-q42 rat S172-p 15176497 QADRVDKsAVGFDYQ HS1_rep molecular association, regulation cytoskeletal reorganization ACTB(DISRUPTS) 26033110 1 4 0 phospho-mimetic mutant shows atypical growth cone filopodia +CCR7 CCR7 GPCR, family 1; Membrane protein, integral; Membrane protein, multi-pass; Motility/polarity/chemotaxis; Receptor, GPCR P32248 1236 17q21.2 human T372-p 455291 SMSVEAEtTTTFSP_ phosphorylation 15054093 1 0 0 ERK1/2 phosphorylation +PTK2 FAK EC 2.7.10.2; KINASE; Kinase, protein; Protein kinase, TK; Protein kinase, tyrosine (non-receptor) Q05397 5747 8q24.3 human Y194-p 18122800 ALEKKSNyEVLEKDV FERM_M protein conformation; phosphorylation; enzymatic activity, induced cell motility, altered; cell growth, altered 20802513 2 2 4 +Met Met EC 2.7.10.1; KINASE; Kinase, protein; Membrane protein, integral; Oncoprotein; Protein kinase, TK; Protein kinase, tyrosine (receptor) P16056 17295 6 A2|6 7.83 cM mouse Y1001-p 448469 VSNESVDyRATFPED ubiquitination cell motility, altered 12244174; 7708691 16 26 366 inhibits cell motility +Nrip1 RIP140 Nuclear receptor co-regulator; Transcription, coactivator/corepressor Q8CBD1 268903 16|16 C3.1 mouse Y418-p 25234800 TPTTIDEySDNNPSF NRIP1_repr_2 protein degradation; ubiquitination 22388040 1 0 0 regulates inflamatory responses and contributes to endotoxin tolerance +Ctnnd1 CTNND1 Actin-binding; Adaptor/scaffold; Cell adhesion; G protein regulator, misc.; Motility/polarity/chemotaxis P30999 12388 2 D|2 49.45 cM mouse S312-p 450458 ARRTGTPsDPRRRLR molecular association, regulation cell adhesion, inhibited 26175155 4 3 2 decreased homophilic binding affinity of E-cadherin +FOXM1 FOXM1 DNA-binding; Transcription factor Q08050 2305 12p13.33 human S730-p 3194570 VLDTMNDsLSKILLD cell cycle regulation; transcription, induced 19160488 2 6 0 orderly mitotic progression +TP53 p53 Activator; DNA-binding; Motility/polarity/chemotaxis; Nuclear receptor co-regulator; Transcription factor; Tumor suppressor P04637 7157 17p13.1 human R337-m2 5009201 LQIRGRErFEMFREL P53_tetramer cell cycle regulation; apoptosis, inhibited; transcription, altered 53BP1(INDUCES) 19011621 1 1 0 PRMT5 enhanced p53-dependent cell-cycle arrest; after treatment with PRMT5 theere was a reduction in dimer and tetramer formation; arginine methylation affects the promoter specificity of p53 +Ppm1h PPM1H EC 3.1.3.16; PHOSPHATASE; Phosphatase Q3UYC0 319468 10|10 D2 mouse S210-p 3215799 RTLTRAAsLRGGVGA phosphorylation; enzymatic activity, induced 32600616 1 22 23 dephosphorylation of SMAD1 +Smo SMO Cell development/differentiation; GPCR, Fz/Smo family; Membrane protein, integral; Membrane protein, multi-pass; Oncoprotein; Receptor, GPCR P56726 319757 6 A3.3|6 12.36 cM mouse T648-p 1872776124 VSVTPVAtPVPPEEQ molecular association, regulation transcription, induced PKACA(INDUCES) 33886552 1 1 0 +ABI1 Abi-1 Adaptor/scaffold; Motility/polarity/chemotaxis Q8IZP0 10006 10p12.1 human T265-p 18715504 GIPIAVPtPSPPTIG molecular association, regulation cell motility, altered; cytoskeletal reorganization 21419341 1 0 2 regulates WRC (WAVE2 regulatory complex) interaction with Arp2/3 and lamellipodial protrusion +INCENP INCENP Cell cycle regulation; EC 2.7.11.1 Q9NQS7 3619 11q12.3 human T59-p 458332 EPELMPKtPSQKNRR molecular association, regulation; intracellular localization cell cycle regulation; chromatin organization, altered KIF20A(DISRUPTS) DNA(DISRUPTS) 19303298; 20619651; 22814604; 29084198; 32356865; 33067654 9 6 21 +Clip1 Restin Cytoskeletal Q922J3 56430 5|5 F mouse S311-p 4769833 ASLKRSPsASSLSSM intracellular localization cytoskeletal reorganization 33251722 4 13 1 +F2R PAR1 Cell development/differentiation; GPCR, family 1; Membrane protein, integral; Membrane protein, multi-pass; Receptor, GPCR P25116 2149 5q13.3 human S406-p 3627500 SSGQLMAsKMDTCSS receptor desensitization, altered 10413505 1 0 0 receptor shutoff (not internalization) +Spi1 PU.1 DNA-binding; Oncoprotein; Transcription factor P17433 20375 2 E1|2 50.44 cM mouse S132-p 478389 LSPAHQQsSDEEEGE molecular association, regulation IRF8(INDUCES); PU.1(INDUCES); IRF2(INDUCES) 17200120 1 1 0 Interaction of PU.1, IRF-2, and IRF-8 requires phosphorylated residues on each protein. +Pcna PCNA Cell cycle regulation; DNA replication P17918 18538 2 F2|2 64.15 cM mouse K164-ub 485775 AVVISCAkNGVKFSA PCNA_C DNA repair, induced; DNA repair, altered 25505145; 28761001 33 14 135 DNA damage tolerance (DDT) allows bypassing of DNA lesions during replication. Translesion synthesis (TLS), template switching (TS) are dependant on PCNA K164 monoubiquitination and polyubiquitination.; K164 ubquitination is importaqnt for bypass of methyl methanesulfonate-induced DNA damage +RIPK1 RIPK1 EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, Ser/Thr (non-receptor); Protein kinase, TKL Q13546 8737 6p25.2 human S320-p 468644 AVVKRMQsLQLDCVA molecular association, regulation; enzymatic activity, inhibited apoptosis, inhibited FADD(DISRUPTS) 28506461; 34965934 11 27 34 +MYLIP MYLIP EC 6.3.2.-; EC 6.3.2.19; Ligase; Motility/polarity/chemotaxis; UBIQUITIN LIGASE; Ubiquitin conjugating system; Ubiquitin ligase Q8WY64 29116 6p22.3 human K293-sm 1881268800 MQYSRDLkGHLASLF protein stabilization endocytosis, inhibited 33154164 1 0 0 counteracts its ubiquitination +ITGB5 ITGB5 Cell adhesion; Membrane protein, integral; Motility/polarity/chemotaxis P18084 3693 3q21.2 human S762-p 14694703 AKFQSERsRARYEMA Integrin_b_cyt cell motility, altered 20507994 1 0 0 +PPARG PPAR-gamma DNA-binding; Nuclear receptor; Transcription factor P37231 5468 3p25.2 human T166-p 1880248400 CKGFFRRtIRLKLIY molecular association, regulation; protein conformation cell differentiation, altered; transcription, inhibited PRDM16(DISRUPTS); PGC-1 alpha(DISRUPTS) DNA(DISRUPTS) 36329235 1 0 0 +CEBPA C/EBP-alpha DNA-binding; Transcription factor P49715 1050 19q13.11 human K298-ac 56394104 RNNIAVRkSRDKAKQ bZIP_2 molecular association, regulation cell differentiation, inhibited; transcription, inhibited DNA(DISRUPTS) 27005833 2 0 0 +Tmbim1 TMBIM1 Membrane protein, integral; Membrane protein, multi-pass Q8BJZ3 69660 1|1 C3 mouse K91-ub 1873041102 PGEWDDRkVRHSFIQ molecular association, regulation Hrs(INDUCES) 28481357 1 1 0 +KDM8 JMJD5 Cell cycle regulation; DEMETHYLASE; Demethylase; EC 1.14.11.27 Q8N371 79831 16p12.1 human S361-p 1877127906 THLLHNTsQVDVENP Cupin_8 protein degradation carcinogenesis, inhibited; cell growth, inhibited 35538499 1 1 0 +SP1 SP1 C2H2-type zinc finger protein; DNA-binding; Transcription factor P08047 6667 12q13.13 human T679-p 25312143 ELQRHKRtHTGEKKF zf-C2H2 protein stabilization; molecular association, regulation carcinogenesis, induced; cell motility, induced; transcription, induced; signaling pathway regulation DNA(INDUCES) 22718198 1 0 1 AKT/SP1/CCR7 pathway +ADRA2A ADRA2A GPCR, family 1; Membrane protein, integral; Membrane protein, multi-pass; Receptor, GPCR P08913 150 10q25.2 human S313-p 456351 LDLEESSsSDHAERP 7tm_1 activity, inhibited 7876239 1 2 0 +TAL1 TAL1 DNA-binding; Oncoprotein; Transcription factor P17542 6886 1p33 human S172-p 4704529 NRVKRRPsPYEMEIT molecular association, regulation transcription, induced LSD1(DISRUPTS) 22310283 2 2 1 +Dcx Doublecortin Cytoskeletal; Motility/polarity/chemotaxis O88809 13193 X|X F2 mouse S47-p 451112 TRTLQALsNEKKAKK molecular association, regulation cell motility, induced; cytoskeletal reorganization TUBA1A(NOT_REPORTED); SPATA13 iso6(INDUCES) 22367209 5 0 0 Rac1 activation, lamellipodia formation +Eif3f eIF3-epsilon EC 3.4.19.12; Translation; Translation initiation Q9DCH4 66085 7|7 E3 mouse K218-ub 7388005 QHGRMSIkAYVSTLM protein degradation 19073596 1 1 0 regulates skeletal muscle atrophy +TRPM8 TRPM8 Channel, cation; Membrane protein, integral; Membrane protein, multi-pass Q7Z2W7 79054 2q37.1 human S1041-p 34360658 KEKNMESsVCCFKNE receptor desensitization, inhibited 32290846 1 0 1 +CTTN Cortactin Actin-binding; Cytoskeletal; Motility/polarity/chemotaxis Q14247 2017 11q13.3 human K203-ac 482876 GGKYGIDkDKVDKSA HS1_rep molecular association, regulation; intracellular localization cell motility, inhibited ACTB(DISRUPTS) 17643370 1 1 0 Acetylation prevents localization to membrane ruf?es. +USP2 USP2 DEUBIQUITINASE; EC 3.4.19.12; Protease; Ubiquitin-specific protease O75604 9099 11q23.3 human T137-p 1880716200 YDQGVTLtQKLDSQS molecular association, regulation DNA repair, induced RECQL4(INDUCES) DNA(INDUCES) 36436562 1 0 0 +Grip1 GRIP1 Adaptor/scaffold P97879 84016 7q22 rat S917-p 471402 EATIMSGsTMSLNHE phosphorylation 17121843 2 0 1 Wild-type GRIP1 and mutant S19A there was a reduction in GluR2 surface expression, while S917 had no effect. +UBE2S UBE2S EC 6.3.2.19; Ligase; UBIQUITIN LIGASE; Ubiquitin conjugating system; Ubiquitin ligase Q16763 27338 19q13.42 human T152-p 58109405 AARARLLtEIHGGAG UQ_con protein stabilization; molecular association, regulation DNA repair, induced Ku80(INDUCES); Ku70(INDUCES) 27593939 1 0 0 +Il1b IL1B Cytokine P10749 16176 2 F1|2 62.97 cM mouse K133-ub 1881312000 RLRDEQQkSLVLSDP protein degradation 33976225 1 0 0 forms an electrostatic interaction with D129, loss of K133 ubiquitylation or the K133:D129 salt bridge stabilizes IL-1B +CTNNB1 CTNNB1 Actin-binding; Cell adhesion; Motility/polarity/chemotaxis; Nuclear receptor co-regulator; Oncoprotein; Transcription factor P35222 1499 3p22.1 human S60-p 1875093002 EEEDVDTsQVLYEWE molecular association, regulation cell cycle regulation ECT2(INDUCES) 34585824 2 0 0 +AHSG FETUA Secreted; Secreted, signal peptide P02765 197 3q27.3 human S138-p 467421 KCDSSPDsAEDVRKV carcinogenesis, induced 36114575 1 55 604 +CILK1 ICK EC 2.7.11.22; KINASE; Kinase, protein; Protein kinase, CMGC; Protein kinase, Ser/Thr (non-receptor) Q9UPZ9 22858 6p12.1 human Y15-p 35479600 RQLGDGTyGSVLLGR Pkinase intracellular localization; enzymatic activity, inhibited signaling pathway regulation 30782830 1 1 0 +TNK2 Ack EC 2.7.10.2; EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, TK; Protein kinase, tyrosine (non-receptor) Q07912 10188 3q29 human Y635-p 4251154 PLPPPPAyDDVAQDE molecular association, regulation; enzymatic activity, induced carcinogenesis, induced; cell growth, induced; transcription, induced; signaling pathway regulation Akt1(INDUCES) 25257795 1 2 5 PDGF-induced PDGFRB-ACK1-AKT signaling +ACP1 ACP1 Cofactor and Vitamin Metabolism - riboflavin; EC 3.1.3.2; EC 3.1.3.48; Motility/polarity/chemotaxis; PHOSPHATASE; Phosphatase (non-protein); Protein phosphatase, tyrosine (non-receptor) P24666 52 2p25.3 human Y132-p 450718 QLIIEDPyYGNDSDF LMWPc phosphorylation; enzymatic activity, induced cell motility, altered; cell adhesion, altered; transcription, altered 10671492; 10980198; 9038134 5 15 194 regulates phosphorylation of p190Rho-GAP; dephosphorylation of RhoGAP, regulates ERK activation +Epha2 EphA2 EC 2.7.10.1; KINASE; Kinase, protein; Membrane protein, integral; Protein kinase, TK; Protein kinase, tyrosine (receptor) Q03145 13836 4 D3|4 73.67 cM mouse Y773-p 450861 EDDPEATyTTSGGKI PK_Tyr_Ser-Thr intracellular localization; phosphorylation cell adhesion, induced; cytoskeletal reorganization 34537369 6 55 860 induces MLC phosphorylation +DUSP10 DUSP10 EC 3.1.3.16; EC 3.1.3.48; Motility/polarity/chemotaxis; PHOSPHATASE; Protein phosphatase, dual-specificity Q9Y6W6 11221 1q41 human S230-p 38520205 DSFKRIFsKEIIVYD Rhodanese cell growth, inhibited; apoptosis, induced 25568665 1 0 0 +CDCA5 CDCA5 Cell cycle regulation Q96FF9 113130 11q13.1 human T159-p 483401 LGSASTStPGRRSCF Sororin molecular association, regulation; activity, inhibited cell cycle regulation SCC-112(DISRUPTS); H2A.1(DISRUPTS); SMC3(DISRUPTS); PLK1(INDUCES) 21878504; 21987589; 23901111 3 10 14 +ZNF692 ZNF692 C2H2-type zinc finger protein; Transcription factor Q9BU19 55657 1q44 human S470-p 471395 VAAHRSKsHPALLLA transcription, inhibited 17097062 1 0 0 inhibits DNA binding and transcription +Hdac1 HDAC1 DEACETYLASE; Deacetylase; EC 3.5.1.98; Hydrolase; Nuclear receptor co-regulator Q4QQW4 297893 5q36 rat K444-sm 2407421 FKKAKRVkTEDEKEK molecular association, regulation neural plasticity; apoptosis, inhibited CREB iso1(DISRUPTS) 28186506 3 1 0 sumoylation rescues synaptic and memory deficits, and reduces amyloid plaque and apoptosis in APP/PS1 mice; Sumoylation increases CREB binding to DNA and mediates A? induction of Mcl-1 expression +KRAS KRas iso2 G protein; G protein, monomeric; G protein, monomeric, Ras; Motility/polarity/chemotaxis; Oncoprotein P01116-2 3845 12p12.1 human K147-ub 15391092 PFIETSAkTRQGVDD Ras protein conformation 33929846 4 6 3 K147 affected the dynamics of SW-I and SW-II residues and parts of H3, CRD-interacting residues of KRAS do not make direct contact with ubiquitin, KRAS?GAP interface in nearly all of the simulated conformers of mUbKRAS147 +ESR1 ER-alpha DNA-binding; Nuclear receptor; Transcription factor P03372 2099 6q25.1-q25.2 human Y537-p 448103 CKNVVPLyDLLLEML activity, induced; protein stabilization; molecular association, regulation; intracellular localization; protein conformation cell growth, induced; transcription, induced PGC-1 alpha(DISRUPTS); EGFR(INDUCES); SRC-1(DISRUPTS) DNA(INDUCES) 10571988; 25386784; 26079946; 27748765; 9500442 10 0 0 +RAD54L RAD54L Cell cycle regulation; DNA repair, damage; EC 3.6.1.-; EC 3.6.4.-; Helicase Q92698 8438 1p34.1 human K515-ac 1876747700 TRSRSSDkVVLVSNY Helicase_C molecular association, regulation DNA repair, induced BRD9(INDUCES) 32457312 1 0 0 Facilitates RAD54 interaction with RAD51, essential for homologous recombination but also cancer drug resistance +Myc Myc DNA-binding; Nucleolus; Oncoprotein; Transcription factor P01108 17869 15 D1|15 26.19 cM mouse K432-ac 460639 EHKLTSEkDLLRKRR Myc-LZ protein stabilization transcription, induced 15572685 1 1 0 +UBA52-RPS27A-UBB-UBC ubiquitin Ubiquitin-like modifier P62988 2p16 human K29-ub 3135200 TIENVKAkIQDKEGI ubiquitin activity, induced; protein degradation; ubiquitination; protein conformation cell cycle regulation; DNA repair, induced; endocytosis, induced; cell growth, inhibited; transcription, induced; transcription, inhibited 31012223; 31135381; 31902824; 32054686; 34239127; 36563124 18 20 136 RNA processing, proteotoxic stress induced K29-linked ubiquitination, reducing K29-linked ubiquitination led to cell cycle arrest, TBK1, PLK1, INCENP and MLKP1 as potential substrates of K29-linked ubiquitination during midbody assembly; USP16 regulates T cell proliferation and cell-cycle entry; promotes loop 1?loop 7 interaction, cholesterol biosynthesis; Ubiquitination of PPP3CB impairs NFAT recruitment and transcription of NFAT-targeted genes; MRE11A promotes its exonuclease activity; clathrin-mediated endocytosis, poly-Ub chain binds to Lys8 at the intracellular N-terminal domain, degradation depends on the poly-ubiquitination of K8; CACNA1C degradation +AIFM1 PDCD8 Apoptosis; EC 1.-.-.-; Mitochondrial; Oxidoreductase O95831 9131 Xq26.1 human K255-ub 573760204 GSQITYEkCLIATGG Pyr_redox_2 molecular association, regulation DNA(INDUCES) 33898171 1 3 0 Deubiquitination of AIF at K244 compromises OXPHOS and induces a switch in cellular metabolism towards glycolysis and disrupts mitochondrial structure. +Camk2b CAMK2B EC 2.7.11.17; KINASE; Kinase, protein; Protein kinase, CAMK; Protein kinase, Ser/Thr (non-receptor) P08413 24245 14q21 rat T321-p 2048069 FSVGRQTtAPATMST molecular association, regulation 26291163 1 2 0 inhibits interaction with F-actin, regulates synaptic plasticity +UBA52-RPS27A-UBB-UBC ubiquitin Ubiquitin-like modifier P62988 2p16 human S65-p 9765472 DYNIQKEsTLHLVLR ubiquitin activity, induced; protein degradation; molecular association, regulation; ubiquitination; intracellular localization; protein conformation; enzymatic activity, induced autophagy, induced optineurin(DISRUPTS); ubiquitin(INDUCES); PARK2(INDUCES) 24660806; 24751536; 24784582; 25527291; 25847540; 25969509; 26161729; 26254304; 26260794; 27035970; 27425610; 28611216; 29133469; 31801089; 34706234 27 17 0 induces mitophagy; improved binding to PINK1 through its extended S65 loop, and is a superior PINK1 substrate; pH change leads to quaternary rearrangement of a phosphorylated K63-linked diubiquitin; modest effects on UBE3C ligase activity ; p-S65 ubiquitin and downstream Parkin-dependent mitophagy, counteracted by PPEF2 +PTK2 FAK iso5 EC 2.7.10.2; KINASE; Kinase, protein; Protein kinase, TK; Protein kinase, tyrosine (non-receptor) Q92063 396416 chicken S30-p 447962 PSRPGYPsPRSSEGF molecular association, regulation P130Cas(DISRUPTS) 11160818 9 18 0 +EMSY EMSY DNA repair, damage; Transcription regulation Q7Z589 56946 11q13.5 human T207-p 1210942 KPRKRRRtNSSSSSP DNA repair, inhibited 28099152 1 18 22 +Tcf3 E2A iso2 Cell development/differentiation; DNA-binding; Oncoprotein; Transcription factor P15806-2 21423 10 C1|10 39.72 cM mouse S527-p 483180 VPRTRTSsTDEVLSL molecular association, regulation 14-3-3 beta(INDUCES) 22354994 1 23 307 +TP73 p73 DNA-binding; Transcription factor; Tumor suppressor O15350 7161 1p36.32 human S388-p 6417400 VPQPLVDsYRQQQQL activity, induced cell cycle regulation; transcription, altered 19158275 1 0 0 regulates genes involved in cell cycle progression +Trpv6 TRPV6 Channel, calcium; Membrane protein, integral; Membrane protein, multi-pass Q9R186 114246 4q23 rat Y202-p 473578 RPHNLIYyGEHPLSF activity, induced 17197020 1 0 0 regulates calcium influx +Prkaa1 AMPKA1 Autophagy; EC 2.7.11.1; EC 2.7.11.26; EC 2.7.11.27; EC 2.7.11.31; KINASE; Kinase, protein; Protein kinase, CAMK; Protein kinase, Ser/Thr (non-receptor) Q5EG47 105787 15|15 A1 mouse S184-p 3195152 DGEFLRTsCGSPNYA Pkinase phosphorylation autophagy, induced 19942859; 35256937 2 6 16 +BHLHE40 BHLHB2 Nucleolus; Transcription regulation O14503 8553 3p26.1 human K279-sm 31089508 GERIGAIkQESEEPP protein stabilization; intracellular localization transcription, inhibited 21829689; 27626674 2 3 0 +HSF1 HSF1 DNA-binding; Transcription factor Q00613 3297 8q24.3 human T120-p 54414377 ENIKRKVtSVSTLKS protein stabilization; molecular association, regulation; protein conformation carcinogenesis, induced; autophagy, induced; cell motility, induced; cell growth, induced; transcription, induced FBXW7(DISRUPTS) DNA(INDUCES) 31409638 1 1 0 promotes carboplatin-induced autophagy; induces proteostasis; binds to PDL-1, HSP70 and HSP40 promoters +FOXO3 FOXO3A Autophagy; DNA-binding; Oncoprotein; Transcription factor O43524 2309 6q21 human S588-p 20799904 QTLSDSLsGSSLYST phosphorylation transcription, induced 17711846 2 1 0 induces phosphorylation of other sites +CCNA2 CCNA2 Cell cycle regulation; Nuclear receptor co-regulator P20248 890 4q27 human K112-ac 7761215 EAEKEAQkKPAESQK Cyclin_N2 protein degradation; molecular association, regulation cell cycle regulation CDK2(DISRUPTS) 19483727; 23760262 2 1 0 +PHOX2A PHOX2A DNA-binding; Transcription factor O14813 401 11q13.4 human S208-p 9400301 ASPRLSPsPLPVALG phosphorylation 19564421 1 2 0 regulates phosphorylation of PHOX2A S153 +NFATC1 NFAT2 DNA-binding; Transcription factor O95644 4772 18q23 human T338-p 1869090804 VPVKSRKtTLEQPPS activity, induced carcinogenesis, induced; cell motility, induced; transcription, induced 31730483 1 0 0 multiple sites mutatnt +KCNQ2 Kv7.2 iso3 Channel, potassium; Membrane protein, integral; Membrane protein, multi-pass O43526-3 3785 20q13.33 human S511-p 12200523 LTPGLKVsIRAVCVM KCNQ_channel activity, induced; molecular association, regulation; intracellular localization Calmodulin(DISRUPTS) 21980481 1 0 0 increases maximal conductance; not an integral part of the M-channel +ARHGAP22 ARHGAP22 GAP; GAP, Rac/Rho Q7Z5H3 58504 10q11.22-q11.23 human S395-p 4751993 LPAHRTSsLDGAAVA molecular association, regulation cell motility, induced 14-3-3 beta(INDUCES) 21969604 2 16 0 +Ptpa PPP2R4 EC 5.2.1.8; Motility/polarity/chemotaxis; Protein phosphatase, regulatory subunit P58389 110854 2 B|2 21.71 cM mouse K310-ub 41493162 FPVIQHFkFGSLLPI PTPA protein degradation; ubiquitination; methylation cytoskeletal reorganization 31160454 1 4 0 mediating the effects of UBE3A on spine morphology. +PML PML iso4 Nucleolus; Oncoprotein; SUMO LIGASE; SUMO conjugating system; SUMO ligase; Transcription factor; Tumor suppressor; Ubiquitin conjugating system P29590-4 5371 15q24.1 human S36-p 451469 PSEGRQPsPSPSPTE protein stabilization apoptosis, altered 15093545 2 15 0 Phosphorylation of PML is associated with enhanced sumoylation and apoptosis induced by As2O3. +TP53 p53 Activator; DNA-binding; Motility/polarity/chemotaxis; Nuclear receptor co-regulator; Transcription factor; Tumor suppressor P04637 7157 17p13.1 human K320-ub 10888802 SSSPQPKkKPLDGEY P53_tetramer protein degradation; molecular association, regulation; intracellular localization KPNA4(DISRUPTS) 19927155 1 2 16 +ARAF ARAF EC 2.7.11.1; KINASE; Kinase, protein; Oncoprotein; Protein kinase, Ser/Thr (non-receptor); Protein kinase, TKL P10398 369 Xp11.3 human S257-p 467474 SDGTPRGsPSPASVS enzymatic activity, induced 18662992 2 30 61 +Emd emerin Cytoskeletal; Membrane protein, integral O08579 13726 X A7.3|X 37.92 cM mouse Y96-p 448938 KDYNDDYyEESYLTT cell motility, induced; transcription, induced; cytoskeletal reorganization 24609268 3 5 124 Y75F and Y96F had reduced expression of vinculin and SRF.; mechanical adaptation of isolated nuclei to force +HNRNPK hnRNP K RNA splicing; RNA-binding; Spliceosome P61978 3190 9q21.32 human Y225-p 456000 IKGRAQPyDPNFYDE translation, altered 12052863 1 1 1 based on Y72/225/230/234/236/380A mutant +IL9R IL9R Membrane protein, integral; Receptor, cytokine Q01113 3581 Xq28 and Yq12 human T520-p 450657 LSKARSWtF______ molecular association, regulation 14-3-3 zeta(INDUCES) 10642536 1 0 0 +ATR ATR EC 2.7.11.1; KINASE; Kinase, protein; Membrane protein, integral; Protein kinase, Ser/Thr (non-receptor); Protein kinase, atypical Q13535 545 3q23 human S428-p 456320 SSNSDGIsPKRRRLS activity, induced; molecular association, regulation; ubiquitination; intracellular localization; phosphorylation; enzymatic activity, induced cell cycle regulation; DNA repair, induced; apoptosis, induced; cell growth, induced; DNA repair, inhibited; transcription, altered; cell growth, altered PIN1(INDUCES); BID(INDUCES) 17976513; 24639502; 26387736; 33857133; 34718349; 35951367; 36563124 25 13 1 MRE11A promotes its exonuclease activity +HOXA10 HOXA10 DNA-binding; Transcription factor P31260 3206 7p15.2 human Y360-p 455551 KEFLFNMyLTRERRL Homeodomain molecular association, regulation; activity, inhibited transcription, induced HOXA10(INDUCES) 12145285 1 0 0 phosphorylation decreases Hox-A10 DNA binding affinity and transcriptional repression activity. +PML PML Nucleolus; Oncoprotein; SUMO LIGASE; SUMO conjugating system; SUMO ligase; Transcription factor; Tumor suppressor; Ubiquitin conjugating system P29590 5371 15q24.1 human S565-p 2479600 VISSSEDsDAENSSS DUF3583 protein degradation; molecular association, regulation apoptosis, inhibited; cell growth, altered SUMO2(INDUCES); SUMO1(INDUCES); SUMO3(INDUCES) 16873060; 19380586 3 11 0 +Kif2a KIF2A iso1 Microtubule-binding; Motor P28740-1 16563 13|13 D2.1 mouse T482-p 50269511 PFRASKLtQVLRDSF Kinesin cytoskeletal reorganization 26344760 1 1 0 suppress neurite outgrowth from round cells +SPTLC1 SPTLC1 EC 2.3.1.50; Lipid Metabolism - sphingolipid; Membrane protein, integral; Transferase O15269 10558 9q22.31 human Y164-p 27930808 KTEEAIIySYGFATI Aminotran_1_2 intracellular localization; enzymatic activity, inhibited apoptosis, inhibited 23629659 1 0 0 +Crhr1 CRF-R1 GPCR, family 2; Membrane protein, integral; Membrane protein, multi-pass; Receptor, GPCR P35353 58959 10q32.1 rat S408-p 2859802 PTRVSFHsIKQSTAV receptor desensitization, altered; receptor internalization, altered 17913459 1 2 2 +PDE11A PDE11A EC 3.1.4.17; EC 3.1.4.35; Mitochondrial; Nucleotide Metabolism - purine; Phosphodiesterase Q9HCR9 50940 2q31.2 human S162-p 2243100 RALLRKAsSLPPTTA enzymatic activity, induced 18312413 2 3 0 +Nr1i3 NR1I3 DNA-binding; Nuclear receptor O35627 12355 1 H3|1 79.21 cM mouse S202-p 458347 LTMEDQIsLLKGAAV Hormone_recep intracellular localization 16377764 1 0 1 +SMAD1 SMAD1 DNA-binding; Transcription factor Q15797 4086 4q31.21 human S463-p 448362 SPHNPISsVS_____ activity, induced; molecular association, regulation; intracellular localization cell growth, inhibited; transcription, induced; transcription, altered SMAD4(INDUCES) 35573984; 9136927; 9335504 12 13 58 +PDHA2 PDHA2 Amino Acid Metabolism - valine, leucine and isoleucine biosynthesis; Carbohydrate Metabolism - butanoate; Carbohydrate Metabolism - citrate (TCA) cycle; Carbohydrate Metabolism - glycolysis and gluconeogenesis; Carbohydrate Metabolism - pyruvate; EC 1.2.4.1; Mitochondrial; Oxidoreductase P29803 5161 4q22.3 human S291-p 458869 TYRYHGHsMSDPGVS E1_dh enzymatic activity, induced 16436377 1 64 617 +MAPRE3 EB3 Microtubule-binding Q9UPY8 22924 2p23.3 human S176-p 4740060 MQTSGRLsNVAPPCI protein stabilization; molecular association, regulation; ubiquitination cell cycle regulation; cytoskeletal reorganization SIAH1(DISRUPTS) 19696028; 23712260 2 6 0 controls microtubule dynamics-cell spreading and adhesion, induces midbody microtubule stability +Sox9 SOX9 DNA-binding; Transcription factor Q04887 20682 11 E2|11 77.27 cM mouse S181-p 456981 YQPRRRKsVKNGQAE activity, induced; intracellular localization carcinogenesis, induced; cell differentiation, induced; transcription, induced 30412364; 33985544; 34254999 12 2 0 +Rps6kb1 p70S6K EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, AGC; Protein kinase, Ser/Thr (non-receptor); Translation Q8BSK8 72508 11|11 C mouse K507-ac 32640201 QPNSGPYkKQAFPMI cell growth, induced 27345368 3 0 0 +P2RY4 P2RY4 GPCR, family 1; Membrane protein, integral; Membrane protein, multi-pass; Receptor, GPCR P51582 5030 Xq13.1 human S334-p 10349701 QPRTAASsLALVSLP receptor desensitization, altered; receptor internalization, altered 11114308 1 0 0 +SNCA SNCA Adaptor/scaffold P37840 6622 4q22.1 human S87-gl 6311902 KTVEGAGsIAAATGF Synuclein protein stabilization 30651314 0 2 0 inhibits the aggregation of alpha-synuclein but can also alter the structure of a-synuclein aggregates in site specific ways, inhibit a-Synuclein toxicity +SPRY2 SPRY2 Adaptor/scaffold; Inhibitor; Motility/polarity/chemotaxis O43597 10253 13q31.1 human Y55-p 448849 AIRNTNEyTEGPTVV activity, induced; protein degradation; molecular association, regulation; activity, inhibited; phosphorylation cell differentiation, altered; transcription, altered GRB2(INDUCES); CBL(INDUCES) 12593795; 12815057; 15564375; 15637081; 16000370; 16479008; 17255109 10 6 89 +CD36 CD36 Cell adhesion; Membrane protein, integral; Membrane protein, multi-pass P16671 948 7q21.11 human K469-ub 2363100 SYCACRSkTIK____ protein degradation; molecular association, regulation; ubiquitination IRS1(INDUCES) 18316598; 29269414 2 0 0 inhibits insulin-stimulated IRS1 degradation, disrupts IRS1 interaction with CUL7 and Fyn, regulates IRS1 ubiquitination +Ankrd54 ANKRD54 Cell cycle regulation Q91WK7 223690 15 E1|15 37.7 cM mouse S17-p 239773905 DESRSGRsSSDGECA molecular association, regulation; intracellular localization LYN(INDUCES) 28924458 1 1 0 nuclear export, cytoplasmic accumulation +CSNK1E CK1E EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, CK1; Protein kinase, Ser/Thr (non-receptor) P49674 1454 22q13.1 human S368-p 449793 NTSPRAIsRVDRERK enzymatic activity, inhibited 10542239; 12223474 2 0 0 some subset of these 8 sites +Oprk1 KOR-1 GPCR, family 1; Membrane protein, integral; Membrane protein, multi-pass; Receptor, GPCR P34975 29335 5q12 rat S369-p 449609 NTVQDPAsMRDVGGM activity, induced; receptor desensitization, altered; receptor internalization, altered; phosphorylation signaling pathway regulation 12815037; 21370032; 31575661 11 1 0 ROS generation through activating JNK-PRDX6 pathway; induces phosphorylation of ERK1/2 and p38MAPK, induces KOR/ p38MAPK signaling +Traf6 TRAF6 EC 6.3.2.-; Ligase; UBIQUITIN LIGASE; Ubiquitin conjugating system; Ubiquitin ligase P70196 22034 2|2 E2 mouse S48-p 1040254702 STGNLSSsFMEEIQG ubiquitination 29563609 1 0 0 colon epithelia in?ammation +ETV1 ETV1 DNA-binding; Oncoprotein; Transcription factor P50549 2115 7p21.2 human T143-p 3059604 NPPTPSStPVSPLHH ETS_PEA3_N activity, induced transcription, induced 12213813 2 0 0 +ELK1 ELK1 DNA-binding; Transcription factor P19419 2002 Xp11.23 human S324-p 471887 RDLELPLsPSLLGGP activity, induced; protein conformation transcription, induced 8262053 2 12 9 +Irf3 IRF3 DNA-binding; Transcription factor P70671 54131 7|7 B3 mouse S97-p 51637401 LRLAADNsKDPYDPH IRF intracellular localization 26692175 4 2 0 dephosphorylated S97 promoted nuclear import +CDKN2D CDKN2D Cell cycle regulation; Inhibitor; Tumor suppressor P55273 1032 19p13.2 human T141-p 25256101 RRDARGLtPLELALQ Ank_2 phosphorylation cell cycle regulation; cell growth, induced 22558186 1 1 0 S76/T141 phosphorylation is necessary for CDKN2D function in DNA repair.; S76 is phosphorylated first, followed by T141 phosphorylation. +PIAS1 PIAS1 EC 6.3.2.-; Nuclear receptor co-regulator; SUMO LIGASE; SUMO conjugating system; SUMO ligase; Transcription, coactivator/corepressor O75925 8554 15q23 human S522-p 3177709 DTSYINTsLIQDYRH sumoylation; enzymatic activity, induced transcription, inhibited 23202365 1 1 0 ; PIAS1 S522A expression inhibits TNF-induced sumoylation of p53; inhibits inflammatory genes expression +RBM39 RNPC2 Nuclear receptor co-regulator; RNA-binding; Spliceosome Q14498 9584 20q11.22 human Y99-p 12244420 RGRYRSPySGPKFNS transcription, induced 27018250 1 4 55 expression of ER (or PR) responsive genes +EZH2 EZH2 EC 2.1.1.43; METHYLTRANSFERASE; Methyltransferase; Methyltransferase, protein lysine Q15910 2146 7q36.1 human T311-p 34490427 NTYKRKNtETALDNK molecular association, regulation; enzymatic activity, inhibited carcinogenesis, inhibited; cell growth, inhibited; transcription, induced SUZ12(INDUCES); RBBP4(DISRUPTS); SUZ12(DISRUPTS) 29351847; 34775498 4 2 0 +SUPT5H SPT5 RNA-binding; Transcription, coactivator/corepressor O00267 6829 19q13.2 human S666-p 468817 VGGFAPMsPRISSPM transcription, induced 34534457 5 85 10 +Prkcd PKCD EC 2.7.11.13; KINASE; Kinase, protein; Nuclear receptor co-regulator; Protein kinase, AGC; Protein kinase, Ser/Thr (non-receptor); Protein kinase, tyrosine (non-receptor); Tumor suppressor P09215 170538 16p16 rat Y512-p 450078 TFCGTPDyIAPEILQ Pkinase enzymatic activity, induced 9326592 3 3 2 +ESRRG ERR3 DNA-binding; Nuclear receptor; Transcription factor P62508 2104 1q41 human K40-sm 6048402 SSCSSFIkTEPSSPA transcription, inhibited 19067653 2 0 0 +Adrb2 ADRB2 GPCR, family 1; Membrane protein, integral; Membrane protein, multi-pass; Receptor, GPCR P04274 101836719 hamster S262-p 447909 GHGLRRSsKFCLKEH 7tm_1 receptor desensitization, altered 8083204 15 2 1 S262 was primary site of cAPK desensitization, while either 261 or 262 for PKC desensitization, as well as ADRB2 expression level. +VHL VHL Tumor suppressor; UBIQUITIN LIGASE; Ubiquitin ligase P40337 7428 3p25.3 human S168-p 27434501 RCLQVVRsLVKPENY VHL_C protein degradation cytoskeletal reorganization 23255108 1 0 0 proteasomal degradation and ciliary destabilization +Nacc1 NAC1 Transcription factor O35260 171454 19q11 rat S245-p 457535 CVSGPSMsERTSPGT intracellular localization 16045493 1 0 0 +MCL1 MCL1 Apoptosis; Channel, misc.; Inhibitor; Membrane protein, integral; Mitochondrial Q07820 4170 1q21.2 human T301-p 1868532700 ITDVLVRtKRDWLVK Bcl-2 molecular association, regulation cell cycle regulation; apoptosis, induced MCL1(INDUCES) 32322059 1 0 0 +Cacng2 Stargazin Channel, calcium; Membrane protein, integral; Membrane protein, multi-pass O88602 12300 15 E1|15 36.92 cM mouse S237-p 455314 RYRYQRRsRSSSRST activity, induced; intracellular localization 15664178; 20670832 3 0 0 AMPAR immobilization in synaptic membrane; enhances AMPA receptor responses and is required for long-term potentiation +BRAF BRAF EC 2.7.11.1; KINASE; Kinase, protein; Oncoprotein; Protein kinase, Ser/Thr (non-receptor); Protein kinase, TKL P15056 673 7q34 human S467-p 28070701 GQRIGSGsFGTVYKG PK_Tyr_Ser-Thr molecular association, regulation; activity, inhibited BRAF(DISRUPTS) 31929109 2 1 0 +ROCK1 ROCK1 EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, AGC; Protein kinase, Ser/Thr (non-receptor) Q13464 6093 18q11.1 human S456-p 2526073 MEQKCRTsNIKLDKI signaling pathway regulation 34530870 1 2 0 induces RhoA/ROCK1/MYPT1 signaling +KIF4A KIF4A Microtubule-binding; Motor O95239 24137 Xq13.1 human K460-sm 610814348 TLEDQELkENVEIIC molecular association, regulation cell cycle regulation STMN1(INDUCES) 32591481 1 2 0 KIF4A regulates abscission, enhances binding to STMN1 identified by mass spectrometry +GLI1 GLI1 C2H2-type zinc finger protein; Oncoprotein; Transcription factor P08151 2735 12q13.3 human S84-p 25123902 LTKKRALsISPLSDA molecular association, regulation; intracellular localization carcinogenesis, induced; cell growth, induced; transcription, induced; signaling pathway regulation SUFU(DISRUPTS) 22439934 1 1 0 mTOR/S6K1 and HH-pathways +SSTR2 SSTR2 GPCR, family 1; Membrane protein, integral; Membrane protein, multi-pass; Receptor, GPCR P30874 6752 17q25.1 human T359-p 12577700 ETTETQRtLLNGDLQ receptor internalization, induced; receptor desensitization, induced; receptor recycling, induced 24565897; 24637622 6 0 0 +Kdm6b JMJD3 DEMETHYLASE; Demethylase; EC 1.14.11.-; Oxidoreductase Q5NCY0 216850 11|11 B3 mouse T1044-p 1867766700 GGVSKVKtPTAPAPP molecular association, regulation; intracellular localization autophagy, induced; transcription, induced PPAR-alpha(INDUCES) 32042044 1 1 0 +UBE2I UBC9 EC 6.3.2.-; EC 6.3.2.19; Ligase; Nuclear receptor co-regulator; SUMO LIGASE; SUMO conjugating system; SUMO ligase; UBIQUITIN LIGASE; Ubiquitin conjugating system; Ubiquitin ligase P63279 7329 16p13.3 human K14-sm 4199300 SRLAQERkAWRKDHP UQ_con sumoylation; molecular association, regulation; intracellular localization; enzymatic activity, induced DAXX(INDUCES); IPO13(INDUCES); SP100(INDUCES); RASD2(INDUCES) 18691969; 19635459; 20424159; 21139563 4 1 0 +Mafa MAFA DNA-binding; Oncoprotein; Transcription factor; Tumor suppressor Q8CF90 378435 15|15 D3 mouse T57-p 456028 LSSTPLStPCSSVPS protein degradation; molecular association, regulation transcription, inhibited MAFA(INDUCES); PSME3(INDUCES) DNA(NOT_REPORTED) 20208071; 21646385 8 1 0 +APP APP Apoptosis; Cell surface; Membrane protein, integral; Receptor, misc.; Transcription factor P05067 351 21q21.3 human S697-me 1881129800 FFAEDVGsNKGAIIG molecular association, regulation APP(NOT_REPORTED) 33328587 1 1 0 formaldehyde (FA) cross-linked with K699 residue in the ?-turn of A? monomer to form A? dimers, and then accelerated A? oligomerization +Gja1 GJA1 Channel, misc.; Membrane protein, integral; Membrane protein, multi-pass; Motility/polarity/chemotaxis P08050 24392 20q11 rat S328-p 449993 GQAGSTIsNSHAQPF Connexin43 intracellular localization cell adhesion, induced; cell adhesion, altered; signaling pathway regulation 12270943; 23742896 10 13 0 cardiomyocyte FGF signaling, maintenance of cell-cell gap junctions +TRPV5 TRPV5 Channel, cation; Membrane protein, integral; Membrane protein, multi-pass; Motility/polarity/chemotaxis Q9NQA5 56302 7q34 human S654-p 470109 YVEVFKNsDKEDDQE activity, induced; intracellular localization 17006539 3 0 0 +KCNMA1 KCNMA1 Channel, potassium; Endoplasmic reticulum; Membrane protein, integral; Membrane protein, multi-pass Q28204 282573 cow T139-p 469977 PVDEKEEtVAAEVGW activity, induced 16341213 1 0 0 CAMK2 phosphorylation switches ethanol induced activation of channel to inhibition. +NFATC1 NFAT2 DNA-binding; Transcription factor O95644 4772 18q23 human K914-sm 6413901 APIPVTVkREPEELD molecular association, regulation; intracellular localization chromatin organization, altered; signaling pathway regulation; transcription, inhibited HDAC1(INDUCES); HDAC2(INDUCES); PML(INDUCES); HDAC4(INDUCES) 19218564; 32986812 2 1 0 K702/914R and K349/702/914R mutants prevented sumoylation in mice, increased IL-2 secretion counteracted IL-17 and IFN-gamma expression +TP53 p53 Activator; DNA-binding; Motility/polarity/chemotaxis; Nuclear receptor co-regulator; Transcription factor; Tumor suppressor P04637 7157 17p13.1 human S185-p 1870414701 HHERCSDsDGLAPPQ P53 molecular association, regulation carcinogenesis, induced; transcription, inhibited DNA(DISRUPTS) 32873634 1 0 0 +NR1I2 PXR DNA-binding; Nuclear receptor O75469 8856 3q13.33 human S350-p 4668103 MQAISLFsPDRPGVL Hormone_recep protein degradation; acetylation; molecular association, regulation; ubiquitination; intracellular localization; protein conformation; activity, inhibited transcription, induced; transcription, inhibited; transcription, altered RORA(INDUCES); RXRA(DISRUPTS); FGR(INDUCES); HSP90A(INDUCES); N-CoR1(DISRUPTS); HSP90A(DISRUPTS); HNF4 alpha(INDUCES); DNAJC7(DISRUPTS) 18784074; 19617467; 22829544; 23264496; 26119819; 32798464; 35053380 9 0 0 +CFL1 Cofilin-1 Cytoskeletal; Motility/polarity/chemotaxis; Nuclear receptor co-regulator P23528 1072 11q13.1 human S3-p 448444 _____MAsGVAVSDG activity, induced; molecular association, regulation; intracellular localization; activity, inhibited; phosphorylation cell cycle regulation; carcinogenesis, induced; cell motility, induced; cell growth, inhibited; cell adhesion, induced; cell motility, inhibited; signaling pathway regulation; autophagy, induced; cell growth, induced; apoptosis, inhibited; cell motility, altered; cell adhesion, altered; cytoskeletal reorganization 14-3-3 zeta(INDUCES); CAP1(DISRUPTS) 11171090; 11276226; 11784854; 12361576; 14634665; 14645219; 17113383; 18070928; 18079118; 18771940; 18957424; 19329994; 20190821; 21571222; 21693580; 23737525; 23841590; 23934191; 24664099; 25595902; 25800056; 26169356; 27153537; 29058761; 31791978; 33657382; 34294886; 34675073; 34995286; 35069199; 35132180; 37059490; 8824278 97 69 3 induces mitophagy +PXN PXN iso2 Adaptor/scaffold; Cell adhesion; Cytoskeletal; Motility/polarity/chemotaxis P49023-2 5829 12q24.23 human S244-p 465487 VNQGEMSsPQRVTST Paxillin molecular association, regulation cell differentiation, induced; cytoskeletal reorganization FAK(INDUCES) 18042622 2 6 2 myelination +KCNJ1 ROMK Channel, potassium; Membrane protein, integral; Membrane protein, multi-pass P48048 3758 11q24.3 human S183-p 2813506 GAILAKIsRPKKRAK IRK activity, induced; intracellular localization 12221079 2 0 0 +ARHGAP21 ARHGAP21 GAP; GAP, Rac/Rho Q5T5U3 57584 10p12.1|10p12.3 human K1443-sm 27850501 ELDNVFFkKENVEQC cell growth, induced 22922005 1 1 0 +Hdac5 HDAC5 DEACETYLASE; Deacetylase; EC 3.5.1.98; Hydrolase Q9Z2V6 15184 11|11 D mouse S250-p 447995 FPLRKTAsEPNLKVR molecular association, regulation 14-3-3 epsilon(INDUCES) 11114197 25 23 25 +MORC3 MORC3 Cell cycle regulation; RNA-binding Q14149 23515 21q22.12 human K794-sm 14988617 CSALQHVkAECSQCS molecular association, regulation PML(INDUCES) 20501696 1 0 0 +HNRNPA1 hnRNP A1 Nuclear export; RNA splicing; RNA-binding; Spliceosome P09651 3178 12q13.13 human S6-p 455946 __MSKSEsPKEPEQL sumoylation; molecular association, regulation; intracellular localization RNA splicing, induced; cell growth, induced; apoptosis, inhibited; translation, induced 14-3-3 sigma(INDUCES); 14-3-3 theta(INDUCES) RNA(INDUCES) 25324306; 29344170 2 96 4 interaction with BCL-XL and XIAP mRNA and regulation of their translation; nuclear import/export; glycolysis +H3c1 H3 DNA-binding P68433 360198 13|13 A3.1 mouse K27-m1 465522 LATKAARkSAPATGG Histone endocytosis, altered; chromatin organization, altered; cell differentiation, induced; cell adhesion, altered; transcription, induced 20574709; 33195484 22 20 47 axon guidance +Lmna lamin A/C Cytoskeletal P48679 60374 2q34 rat S404-p 478681 RSRGRASsHSSQSQG activity, induced; protein degradation cell differentiation, induced 18808171; 26045045 8 49 106 nucleus morphology; reduced nuclear size +EIF4E EIF4E Translation; Translation initiation P06730 1977 4q23 human S209-p 447776 DTATKSGsTTKNRFV activity, induced; sumoylation; protein degradation; molecular association, regulation; enzymatic activity, induced carcinogenesis, induced; cell growth, induced; apoptosis, inhibited; translation, induced; cell growth, altered 4E-T(INDUCES); 4E-BP1(DISRUPTS) RNA(INDUCES); RNA(DISRUPTS) 15574771; 16540463; 19934253; 20008839; 25915158; 25923732; 28745319; 31903169; 34012509 64 4 0 +Gorasp2 GRASP55 Motility/polarity/chemotaxis; Vesicle Q9R064 113961 3q22 rat T249-p 2756300 PSLSPPGtAGVEQSL cell cycle regulation 18385516 2 0 1 +RICTOR RICTOR Adaptor/scaffold; Cell cycle regulation; Ubiquitin conjugating system Q6R327 253260 5p13.1 human T1135-p 458276 NRRIRTLtEPSVDFN RICTOR_phospho molecular association, regulation; ubiquitination; phosphorylation 14-3-3 beta(INDUCES); 14-3-3 epsilon(INDUCES); CUL1(DISRUPTS) 19720745; 19935711; 20832730; 22310280 11 14 173 ILK/Rictor complex formation in cancer but not in normal cell types; T1135 phosphorylation reduces Rictor ubiquitination of SGK1. +Tp53 p53 Activator; DNA-binding; Motility/polarity/chemotaxis; Nuclear receptor co-regulator; Transcription factor; Tumor suppressor P10361 24842 10q24 rat K118-ac 474514 FLQSGTAkSVMCTYS P53 molecular association, regulation apoptosis, induced; transcription, induced DNA(DISRUPTS) 24096875 44 8 0 +TNFRSF1B TNF-R2 Membrane protein, integral; Receptor, cytokine P20333 7133 1p36.22 human T436-p 11493000 AFRSQLEtPETLLGS activity, inhibited 9535738 1 0 0 may inhibit activation of NF-kB. +YARS1 YARS Aminoacyl-tRNA synthetase; EC 6.1.1.1; Ligase; Translation; Translation regulation P54577 8565 1p35.1 human K244-ac 62952700 RKEDVKKkLKKAFCE tRNA-synt_1b intracellular localization; enzymatic activity, inhibited; protein conformation DNA repair, induced; transcription, induced 28069943 1 0 0 promotes nuclear translocation, prevents DNA damage by oxidative stress +PDGFRB PDGFRB EC 2.7.10.1; KINASE; Kinase, protein; Membrane protein, integral; Oncoprotein; Protein kinase, TK; Protein kinase, tyrosine (receptor) P09619 5159 5q32 human Y775-p 449964 SSNYMAPyDNYVPSA PK_Tyr_Ser-Thr molecular association, regulation GRB7(INDUCES) 8940081 3 2 2 +H3-3A H3F3A DNA-binding P84243 3020 1q42.12 human S31-p 18545303 AARKSAPsTGGVKKP Histone intracellular localization 37638746 5 6 0 H3.3S31Ph was accumulated at FKBP5 SE during induction in parental cells +Rps6kb1 p70S6K EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, AGC; Protein kinase, Ser/Thr (non-receptor); Translation P67999 83840 10q26 rat T444-p 448358 RFIGSPRtPVSPVKF enzymatic activity, induced 11705993; 15774499 106 37 109 +HNRNPK hnRNP K RNA splicing; RNA-binding; Spliceosome P61978 3190 9q21.32 human R258-m2 6742805 VGFPMRGrGGFDRMP molecular association, regulation translation, inhibited RPS19(INDUCES) 33660773 2 3 1 suppression of ALOX15 mRNA translation initiation +PACS2 PACS2 Q86VP3 23241 14q32.33 human S208-p 1884003502 EEYESFSsEQEASDD intracellular localization 37523531 1 0 0 +KCND3 Kv4.3 Channel, potassium; Membrane protein, integral; Membrane protein, multi-pass Q9UK17 3752 1p13.2 human T504-p 11139168 LLSVRTStIKNHEFI DUF3399 activity, inhibited 28919864 1 0 1 +Dgkg DGKG EC 2.7.1.107; Kinase, lipid; Lipid Metabolism - glycerolipid; Lipid Metabolism - glycerophospholipid; Motility/polarity/chemotaxis P49620 25666 11q23 rat S776-p 471077 MGPPQKSsFFSLRRK enzymatic activity, induced 16905533 1 0 0 +DNM2 DYN2 EC 3.6.5.5; Hydrolase; Microtubule-binding; Motility/polarity/chemotaxis; Vesicle P50570 1785 19p13.2 human T766-p 452323 SASSHSPtPQRRPVS molecular association, regulation 20889493 1 7 0 reduces microtubule-binding activity of DYN2 +Rin1 Rin1 GEF; GEF, Rab Q921Q7 225870 19|19 A mouse Y147-p 2796500 LVQLICGyCRTRAIH molecular association, regulation Arg(INDUCES) 15886098 1 0 0 +ARHGAP24 ARHGAP24 GAP; GAP, Rac/Rho; Motility/polarity/chemotaxis Q8N264 83478 4q21.23-q21.3 human S402-p 4757006 LSGSKTNsPKNSVHK activity, induced cytoskeletal reorganization 16862148 2 8 0 membrane blebbing +Spry2 SPRY2 Adaptor/scaffold; Inhibitor; Motility/polarity/chemotaxis Q9QXV8 24064 14 E2.3|14 56.16 cM mouse Y55-p 448849 AIRNTNEyTEGPTVV activity, induced; molecular association, regulation; activity, inhibited GRB2(INDUCES); CBL(INDUCES) 12402043; 15004239 10 6 89 +JAK3 JAK3 EC 2.7.10.2; KINASE; Kinase, protein; Protein kinase, TK; Protein kinase, tyrosine (non-receptor) P52333 3718 19p13.11 human Y981-p 447637 LPLDKDYyVVREPGQ PK_Tyr_Ser-Thr enzymatic activity, inhibited 9391116 6 3 2 +SKA3 SKA3 Cell cycle regulation Q8IX90 221150 13q12.11 human T360-p 459963 ENLLRTPtPPEVTKI molecular association, regulation; intracellular localization cell cycle regulation; cell growth, induced; chromatin organization, altered; cytoskeletal reorganization PLK1(INDUCES); HEC1(INDUCES) 28479321; 32491969; 33106477 3 8 11 regulation of Akt phosphorylation via PLK1, regulation of SKA3 glycolytic activity +GPRC5A RAIG1 GPCR, family 3; Membrane protein, integral; Membrane protein, multi-pass; Receptor, GPCR Q8NFJ5 9052 12p13.1 human Y317-p 451750 EETGDTLyAPYSTHF cell growth, induced 25311788 1 12 292 Tyrosine phosphorylation inhibits the suppressive effect of RAIG1 on cell invasion and anchorage-independent growth. +Rab3ip RAB3IP GEF; GEF, Rab Q62739 29885 7q22 rat S16-p 37039802 FHEVNLAsPTSPDLL activity, induced; molecular association, regulation; protein conformation; enzymatic activity, induced exocytosis, induced RAB11A(DISRUPTS); RAB8A(INDUCES) 25535387 1 0 0 induces GEF activity of RAB3IP, induces RAB8 activity +FLT3 FLT3 EC 2.7.10.1; KINASE; Kinase, protein; Membrane protein, integral; Oncoprotein; Protein kinase, TK; Protein kinase, tyrosine (receptor) P36888 2322 13q12.2 human Y589-p 448189 TGSSDNEyFYVDFRE molecular association, regulation; enzymatic activity, inhibited; phosphorylation cell growth, altered Src(INDUCES) 11971190; 16627759; 16684964 6 0 1 The double mutation Y589/591F has a slower growth rate (this is in the ligand-independent, constitutive active allele). +GATA6 GATA6 Motility/polarity/chemotaxis; Transcription factor Q92908 2627 18q11.2 human S266-p 2833503 VSARFPYsPSPPMAN GATA-N transcription, induced; cell growth, altered 18454176 2 3 3 +ITGB1 ITGB1 Cell adhesion; Cell surface; Membrane protein, integral; Motility/polarity/chemotaxis; Receptor, misc. P05556 3688 10p11.22 human Y783-p 447710 DTGENPIyKSAVTTV Integrin_b_cyt molecular association, regulation; intracellular localization tensin 1 iso1(INDUCES) 17473008 7 42 1183 preference for the first, membrane-proximal, NPxY motif; phosphorylation does not seem to affect tensin binding; however, in vivo, tensin competes with talin which prefers non-phosphorylated sites +HSP90AA1 HSP90A Chaperone; Heat shock protein P07900 3320 14q32.31 human K546-ac 479635 KTLVSVTkEGLELPE HSP90 molecular association, regulation CHIP(DISRUPTS); TEBP(DISRUPTS); HSP70(DISRUPTS); HSP40(DISRUPTS) 18559531 1 3 2 +ZBTB16 PLZF C2H2-type zinc finger protein; DNA-binding; Oncoprotein; Transcription, coactivator/corepressor Q05516 7704 11q23.2 human K396-sm 2303902 GELAVGMkSESRTIG cell growth, inhibited; transcription, inhibited 17498654 1 0 0 +LAX1 LAX1 Adaptor/scaffold; Membrane protein, integral Q8IWV1 54900 1q32.1 human Y294-p 35546001 AFQCCRDyENVPAAD LAX molecular association, regulation transcription, inhibited; signaling pathway regulation GRB2(INDUCES); GADS(INDUCES); PIK3R1(INDUCES) 12359715 1 0 0 +IL6ST gp130 Membrane protein, integral; Receptor, cytokine P40189 3572 5q11.2 human K849-ub 964517458 EEDFVRLkQQISDHI receptor internalization, induced; protein degradation transcription, inhibited 34785732 1 1 0 In IL6R K401R and gp130 K849R mutants, IL-6-induced transcription of downstream genes compared to wild-type receptors. +LRP2 LRP2 Membrane protein, integral; Motility/polarity/chemotaxis; Receptor, misc. P98164 4036 2q31.1 human S4616-p 767904 VAATPPPsPSLPAKP receptor internalization, altered; receptor recycling, altered 17555532 1 7 0 +Tiam2 TIAM2 Apoptosis; GEF; GEF, Rac/Rho Q6ZPF3 24001 17 A1|17 1.99 cM mouse T749-p 15503728 DSTLRKRtLSLTQRG cell growth, induced; cytoskeletal reorganization; signaling pathway regulation 21460187 1 0 0 induces PKA/TIAM2/RAC1 pathway and neurite outgrowth +NF1 NF1 iso2 GAP; GAP, Ras; Motility/polarity/chemotaxis; Nucleolus; Tumor suppressor P21359-2 4763 17q11.2 human S2580-p 456017 RKVSVSEsNVLLDEE molecular association, regulation; activity, inhibited 14-3-3 beta(INDUCES) 14741381 1 1 0 +Cish CISH O70512 83681 8q32 rat K71-ub 37044805 GDLLCIAkTFSYLRE protein degradation 25448846 1 0 0 +TRIM29 TRIM29 Transcription factor; UBIQUITIN LIGASE; Ubiquitin ligase Q14134 23650 11q23.3 human S552-p 27457998 PSLMRSQsPKAQPQT apoptosis, inhibited 24469230 1 2 0 radioresistance +Coro1a coronin 1A Cytoskeletal; Motility/polarity/chemotaxis O89053 12721 7 69.25 cM|7 F3 mouse S2-p 14571846 ______MsRQVVRSS intracellular localization exocytosis, altered; cytoskeletal reorganization 21844203 2 1 0 inhibits MC (mast cells) degranulation +LATS1 LATS1 EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, AGC; Protein kinase, Ser/Thr (non-receptor); Tumor suppressor O95835 9113 6q25.1 human S872-p 1791604 GDHPRQDsMDFSNEW Pkinase protein degradation; intracellular localization; phosphorylation carcinogenesis, inhibited; signaling pathway regulation 31239271 2 2 2 induces phosphorylation, localization and degradation of YAP, inhibits YAP signaling mediated carcinogenesis +NCBP1 NCBP1 RNA processing; Spliceosome; Translation Q09161 4686 9q22.33 human T21-p 480103 QPHKRRKtSDANETE RNA splicing, altered 10973943 1 28 68 +FOXM1 FOXM1 iso2 DNA-binding; Transcription factor Q08050-2 2305 12p13.33 human K201-sm 31898500 GLGSRSIkQEMEEKE protein degradation transcription, inhibited 25533473 2 1 0 +GLE1 GLE1 Karyopherin; Nuclear export Q53GS7 2733 9q34.11 human S93-p 31084897 PKSPDASsAFSPASP molecular association, regulation GLE1(INDUCES) 30429220 1 2 0 self-association stress granules' assembly and disassembly, DDX3-ATPase activity inhibited +SCN5A SCN5A Channel, sodium; Membrane protein, integral; Membrane protein, multi-pass Q14524 6331 3p22.2 human S483-p 3799151 SKRRKRMsSGTEECG protein conformation 33410863 4 6 4 +FLT1 VEGFR1 EC 2.7.10.1; KINASE; Kinase, protein; Membrane protein, integral; Protein kinase, TK; Protein kinase, tyrosine (receptor) P17948 2321 13q12.3 human Y1242-p 448210 ATSMFDDyQGDSSTL cell cycle regulation; cell growth, altered 11583921 2 1 2 mutation to phenylalanine caused increased tyrosine phosphorylation of PLCG1 +AVPR2 AVPR2 GPCR, family 1; Membrane protein, integral; Membrane protein, multi-pass; Receptor, GPCR; Transporter; Transporter, aquaporin family P30518 554 Xq28 human S363-p 451068 ESCTTASsSLAKDTS intracellular localization; receptor recycling, altered 11150299; 9482866 2 0 0 After receptor activation, phosphorylation of serines 362, 363, and 364 inhibits overall dephosphorylation of the internalized receptor, thereby inhibiting recycling of the receptor to the cell surface. +WNK3 WNK3 EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, Other; Protein kinase, Ser/Thr (non-receptor) Q9BYP7 65267 Xp11.22 human T541-p 1876335000 TGAECEEtEVDQHVR molecular association, regulation KLHL3(DISRUPTS) 35179207 1 0 0 +Npm1 NPM1 Nucleolus; Oncoprotein; RNA-binding; Translation Q61937 18148 11|11 A4 mouse S125-p 459897 AVEEDAEsEDEDEED intracellular localization; protein conformation; phosphorylation carcinogenesis, induced; cell motility, induced; cell growth, induced; apoptosis, inhibited; signaling pathway regulation 24616519; 32606971 11 95 558 induces ERK phosphorylation and NFKB translocation thus inducing ERK/NF-K? signaling +CERS6 LASS6 DNA-binding; Membrane protein, integral; Membrane protein, multi-pass Q6ZMG9 253782 2q24.3 human S346-p 22350309 DRSDIESsSDEEDSE enzymatic activity, induced 26887952 1 3 0 +CYTH1 cytohesin 1 GEF; GEF, ARF; Motility/polarity/chemotaxis Q15438 9267 17q25.3 human T395-p 1319400 RKKKVSStKRH____ activity, induced 18042453 1 0 0 increase in exchange activity, GRP1 autoinhibition reversed +CREB1 CREB DNA-binding; Transcription factor P16220 1385 2q33.3 human S256-p 3181028 APGVVMAsSPALPTQ molecular association, regulation cell cycle regulation; transcription, inhibited DNA(DISRUPTS) 23814058 1 2 0 promotes dissociation from chromatin +NCF1 p47phox EC 1.-.-.-; Oxidoreductase P14598 653361 7q11.23 human S303-p 449405 RGAPPRRsSIRNAHS NECFESHC activity, induced; molecular association, regulation; enzymatic activity, induced CYBA(INDUCES) 10559253; 12056906 9 0 0 +PDK1 PDHK1 EC 2.7.11.2; KINASE; Kinase, protein; Mitochondrial; Protein kinase, Ser/Thr (non-receptor); Protein kinase, atypical Q15118 5163 2q31.1 human Y243-p 462384 ARRLCDLyYINSPEL intracellular localization 22195962 2 1 2 localized to mitochondria in cancer cells +PTEN PTEN Carbohydrate Metabolism - inositol phosphate; EC 3.1.3.16; EC 3.1.3.48; EC 3.1.3.67; Motility/polarity/chemotaxis; Nuclear receptor co-regulator; PHOSPHATASE; Phosphatase, lipid; Tumor suppressor P60484 5728 10q23.31 human S113-p 33636428 EDLDQWLsEDDNHVA intracellular localization autophagy, induced 25701194 1 0 1 nuclear translocation +CHMP4C CHMP4C Vesicle Q96CF2 92421 8q21.13 human S210-p 25123900 MSSTARRsRAASSQR molecular association, regulation; intracellular localization cell cycle regulation VPS4B(INDUCES); VPS4A(INDUCES) 22422861; 22724069; 29362225; 30905608 4 0 0 high cytokinetic cells; mutations of site increase cytokinesis failure +CSRP1 CSRP1 Cytoskeletal; Motility/polarity/chemotaxis P21291 1465 1q32.1 human Y57-p 2091906 AVHGEEIyCKSCYGK LIM intracellular localization 12802285 1 2 8 +CORO7 coronin 7 Vesicle P57737 79585 16p13.3 human Y712-p 1871177706 SERQLLLyEAEALAG phosphorylation signaling pathway regulation 33162394 1 0 0 inhibits phosphorylation of YAP7 and hence the Hippo signaling pathway +IRS2 IRS2 Adaptor/scaffold; Motility/polarity/chemotaxis Q9Y4H2 8660 13q34 human S388-p 1984212 RPVSVAGsPLSPGPV activity, inhibited 34731634 1 30 32 +Rela NFkB-p65 DNA-binding; Nuclear receptor co-regulator; Transcription factor Q04207 19697 19 A|19 4.34 cM mouse S467-p 451145 GVFTDLAsVDNSEFQ protein degradation; ubiquitination transcription, induced; translation, induced; transcription, inhibited COMMD1(INDUCES); CUL2(INDUCES) 19270718; 28723419 22 0 0 regulate locomotor activity and energy expenditure; TNF induced degradation +AKT1 Akt1 EC 2.7.11.1; KINASE; Kinase, protein; Oncoprotein; Protein kinase, AGC; Protein kinase, Ser/Thr (non-receptor) P31749 207 14q32.33 human K14-m1 58948913 VKEGWLHkRGEYIKT PH activity, induced; intracellular localization; phosphorylation cell growth, induced 27626683 1 0 0 +RAC1 RAC1 G protein; G protein, monomeric; G protein, monomeric, Rho; Motility/polarity/chemotaxis P63000 5879 7p22.1 human K5-ub 573766214 ___MQAIkCVVVGDG Ras carcinogenesis, inhibited; signaling pathway regulation 35858925 1 1 0 RAC1-MAPK signaling axis, Trim72 signi?cantly inhibited the tumorigenesis of HCC i +FHL2 FHL2 Motility/polarity/chemotaxis; Nuclear receptor co-regulator; Transcription, coactivator/corepressor Q14192 2274 2q12.2 human Y217-p 1873117006 LNCFCDLyAKKCAGC LIM cell cycle regulation; cell growth, inhibited 33932144 1 1 0 +Net1 NET1 GEF; GEF, Rac/Rho; Motility/polarity/chemotaxis; Oncoprotein Q9Z206 56349 13|13 A1 mouse Y427-p 1881982104 ERHLYQVyRQPIPVQ intracellular localization cell motility, induced; cytoskeletal reorganization; signaling pathway regulation 37271338 1 1 0 induces EGF-stimulated RhoA signaling +Disc1 DISC1 Cell development/differentiation; Motility/polarity/chemotaxis Q811T9 244667 8 E2|8 73.26 cM mouse K640-sm 62504401 SRRLGIVkEDHLRCR intracellular localization cell growth, induced 27525255 1 0 0 +MFF MFF Membrane protein, integral; Mitochondrial Q9GZY8 56947 2q36.3 human S155-p 470753 GRLKRERsMSENAVR Miff ubiquitination cell cycle regulation; carcinogenesis, induced; cell growth, induced; transcription, induced 34010649; 35316673 4 43 91 inhibits ubiquitination and induces stability of Cyclin B1; induce VDAC1 oligomerization +RAD18 RAD18 DNA repair, damage; EC 6.3.2.-; EC 6.3.2.19; Ligase; UBIQUITIN LIGASE; Ubiquitin conjugating system; Ubiquitin ligase Q9NS91 56852 3p25.3 human S434-p 17595902 IQEVLSSsESDSCNS molecular association, regulation POLQ(INDUCES) 21098111 2 0 0 promotes POLQ recruitment to stalled replication forks +PIAS1 PIAS1 EC 6.3.2.-; Nuclear receptor co-regulator; SUMO LIGASE; SUMO conjugating system; SUMO ligase; Transcription, coactivator/corepressor O75925 8554 15q23 human K30-ub 53747700 LGYAGRNkHGRKHEL protein degradation translation, inhibited 26157031 1 0 0 +MAX MAX DNA-binding; Transcription factor P61244 4149 14q23.3 human S11-p 449308 NDDIEVEsDEEQPRF molecular association, regulation; activity, inhibited transcription, altered DNA(DISRUPTS) 37642402; 8018564 5 28 0 phosphorylation-deficient mutant inhibits transcription more efficiently +Zap70 ZAP70 EC 2.7.10.2; KINASE; Kinase, protein; Protein kinase, TK; Protein kinase, tyrosine (non-receptor) P43404 22637 1 B|1 15.41 cM mouse Y492-p 447505 LGADDSYyTARSAGK PK_Tyr_Ser-Thr intracellular localization; enzymatic activity, induced signaling pathway regulation 15699109; 34452999 28 13 427 weak enzymatic activation; regulates TCR signaling +NFE2L2 NRF2 DNA-binding; Transcription factor Q16236 4780 2q31.2 human S344-p 18258505 AEFNDSDsGISLNTS protein degradation; molecular association, regulation; ubiquitination transcription, inhibited BTRC(INDUCES) 22751928; 32295843 4 1 0 +RB1 Rb Nuclear receptor co-regulator; Oncoprotein; Transcription, coactivator/corepressor; Tumor suppressor P06400 5925 13q14.2 human R798-m2 36533406 KFPSSPLrIPGGNIY Rb_C phosphorylation cell cycle regulation; transcription, inhibited 25348716 1 0 0 +PDCD6IP Alix Adaptor/scaffold; Apoptosis Q8WUM4 10015 3p22.3 human K501-ub 3935334 NFRTVLDkAVQADGQ ALIX_LYPXL_bnd molecular association, regulation; ubiquitination 30760577 1 8 16 interaction with Gag and Alix +Oprm1 MOR-1 GPCR, family 1; Membrane protein, integral; Membrane protein, multi-pass; Receptor, GPCR P33535 25601 1q11 rat S363-p 447783 STIEQQNsTRVRQNT molecular association, regulation; receptor desensitization, altered; receptor internalization, altered ARR3(INDUCES); ARRB2(INDUCES) 11278523; 18558479; 23106126 11 6 0 +THRB TR-beta1 DNA-binding; Nuclear receptor P10828 7068 3p24.2 human Y406-p 976541 FLLAFEHyINYRKHH Hormone_recep activity, induced; protein degradation carcinogenesis, inhibited; cell growth, inhibited; signaling pathway regulation 25275301; 27254276 2 1 0 cSrc-FAK-KRAS-ERK signaling; induce TR-beta1 degradation and decreased src signaling; TR-beta1Y406F loses tumor supressor function +Errfi1 MIG-6 Inhibitor; Tumor suppressor P05432 313729 5q36 rat S250-p 3215403 RRLRRSHsGPAGSFN protein stabilization; molecular association, regulation 14-3-3 theta(INDUCES) 23432726 3 41 39 +PTEN PTEN Carbohydrate Metabolism - inositol phosphate; EC 3.1.3.16; EC 3.1.3.48; EC 3.1.3.67; Motility/polarity/chemotaxis; Nuclear receptor co-regulator; PHOSPHATASE; Phosphatase, lipid; Tumor suppressor P60484 5728 10q23.31 human K66-ub 27205468 SKHKNHYkIYNLCAE protein degradation; ubiquitination 27405757; 30631154 3 3 0 PTEN dephosphorylates master regulators of EMT in vivo; K27-linked polyubiquitination alters PTEN substrate binding; converted PTEN from a phosphoinositide/protein tyrosine phosphatase to a protein serine/threonine phosphatase +SCFD1 SCFD1 Vesicle Q8WVM8 23256 14q12 human K126-ac 38507606 ISAISRSkLEDIANA Sec1 autophagy, inhibited 35465820 1 1 2 SCFD1 deacetylation promotes SNARE complex formation +Cops3 COPS3 Ubiquitin conjugating system O88543 26572 11|11 B1.3 mouse S410-p 482300 FVQKSMGsQEDDSGN DNA repair, induced 25855810 1 18 2 +H3c1 H3 DNA-binding P68433 360198 13|13 A3.1 mouse K23-m1 7836400 PRKQLATkAARKSAP Histone chromatin organization, altered 19434510 0 4 19 regulation of senescence-related epigenetics modification +TP53BP2 53BP2 Transcription, coactivator/corepressor Q13625 7159 1q41 human Y869-p 36747002 YLEEYPPyPPPPYPS protein degradation; molecular association, regulation; intracellular localization; phosphorylation transcription, induced 53BP2(INDUCES) 25360797 1 0 0 promotes the dephosphorylation of YAP +Gap43 GAP43 Cell surface P06837 14432 16 B4|16 28.37 cM mouse S41-p 448719 AATKIQAsFRGHITR IQ cell growth, altered 16522636 14 9 5 +STYK1 STYK1 EC 2.7.10.2; KINASE; Kinase, protein; Membrane protein, integral; Oncoprotein; Protein kinase, TK; Protein kinase, tyrosine (non-receptor); Protein kinase, tyrosine (receptor) Q6J9G0 55359 12p13.2 human Y191-p 1869546304 CTEKLPLyMVLEDVA PK_Tyr_Ser-Thr molecular association, regulation; phosphorylation; enzymatic activity, induced STYK1(INDUCES); PIK3R4(INDUCES); PIK3C3(INDUCES); ATG14(INDUCES) 31696776 1 0 0 induces formation of PtdIns3K-C1 complex +Cnr1 CNR1 GPCR, family 1; Membrane protein, integral; Membrane protein, multi-pass; Receptor, GPCR P20272 25248 5q21 rat T314-p 3989689 VRMIQRGtQKSIIIH 7tm_1 exocytosis, inhibited 33582301 1 3 1 +PHLPP1 PHLPP EC 3.1.3.16; PHOSPHATASE; Protein phosphatase, Ser/Thr (non-receptor); Tumor suppressor O60346 23239 18q21.33 human S323-p 31884076 ASPAPSDsSPGEPFV cell cycle regulation 33397691 1 2 0 +PBXIP1 PBXIP1 Cytoskeletal Q96AQ6 57326 1q21.3 human K274-ub 15394414 NMGLLLDkLAKENQD protein degradation; ubiquitination cell cycle regulation 31101654; 34716429 2 0 3 regulation of the G2/M transition +Prkcb PKCB iso2 EC 2.7.11.13; KINASE; Kinase, protein; Motility/polarity/chemotaxis; Protein kinase, AGC; Protein kinase, Ser/Thr (non-receptor) P68404-2 18751 7 F2|7 65.75 cM mouse S660-p 1869073011 QSEFEGFsFVNSEFL Pkinase_C molecular association, regulation mTOR(DISRUPTS) 33850054 14 34 140 +Ceacam1 CEACAM1 Cell adhesion; Immunoglobulin superfamily; Membrane protein, integral; Motility/polarity/chemotaxis P31809 26365 7 A3|7 13.84 cM mouse S503-p 448536 QQPNRPTsAPSSPRA molecular association, regulation cell growth, altered SHC1(INDUCES) 11694516 11 2 0 +MAPK3 ERK1 iso3 EC 2.7.11.24; KINASE; Kinase, protein; Protein kinase, CMGC; Protein kinase, Ser/Thr (non-receptor) P27361-3 5595 16p11.2 human S343-p 50703500 PTDEVGQsPAAVGLG molecular association, regulation; intracellular localization; enzymatic activity, induced cell growth, induced 14-3-3 gamma(INDUCES); PIK4CB(INDUCES) 26459638 1 0 0 translocated to the Golgi in mitosis +PLK1 PLK1 EC 2.7.11.21; KINASE; Kinase, protein; Protein kinase, Other; Protein kinase, Ser/Thr (non-receptor) P53350 5347 16p12.2 human S330-p 4271242 PRFSIAPsSLDPSNR molecular association, regulation cell cycle regulation 14-3-3 zeta(INDUCES) 22202082; 23046929 2 0 0 +Irs1 IRS1 Adaptor/scaffold; Motility/polarity/chemotaxis P35570 25467 9q34 rat S1100-p 453434 GCRRRHSsETFSAPT activity, inhibited 17709744; 36224569 13 39 122 +DEPTOR DEPTOR Apoptosis Q8TB45 64798 8q24.12 human S283-p 4723843 VRRSSMSsCGSSGYF protein degradation; molecular association, regulation carcinogenesis, induced; apoptosis, inhibited; signaling pathway regulation mTOR(DISRUPTS) 19446321 2 2 0 PI3K-Akt signaling +MALT1 MALT1 Adaptor/scaffold; Apoptosis; EC 3.4.22.-; Ligase; Nuclear export; Protease; UBIQUITIN LIGASE; Ubiquitin conjugating system Q9UDY8 10892 18q21.32 human S814-p 1870751203 TTDEIPFsFSDRLRI carcinogenesis, induced; cell growth, induced; transcription, induced; signaling pathway regulation 31644910 1 1 0 activates transcription of NF-kB +MAPK8 JNK1 EC 2.7.11.24; KINASE; Kinase, protein; Protein kinase, CMGC; Protein kinase, Ser/Thr (non-receptor) P45983 5599 10q11.22 human K68-ub 573764264 FQNQTHAkRAYRELV Pkinase activity, inhibited; phosphorylation transcription, inhibited MKK7(DISRUPTS) 28753655 1 3 0 phosphorylation inhibited +FBXL20 FBXL20 UBIQUITIN LIGASE; Ubiquitin ligase Q96IG2 84961 17q12 human S421-p 467840 APVTPPPsVGGSRQR protein degradation; molecular association, regulation carcinogenesis, inhibited; cell growth, inhibited; apoptosis, induced FBXO31(INDUCES) 34587475 1 28 9 +CLDN16 Claudin-16 Cell adhesion; Membrane protein, integral; Membrane protein, multi-pass Q9Y5I7 10686 3q28 human S147-p 32001600 VDVYVERsTLVLHNI PMP22_Claudin molecular association, regulation; intracellular localization endocytosis, induced STX8(INDUCES) 24659781; 28623232 2 0 0 +PDGFRB PDGFRB EC 2.7.10.1; KINASE; Kinase, protein; Membrane protein, integral; Oncoprotein; Protein kinase, TK; Protein kinase, tyrosine (receptor) P09619 5159 5q32 human Y751-p 447508 SKDESVDyVPMLDMK PK_Tyr_Ser-Thr activity, induced; molecular association, regulation; protein conformation; enzymatic activity, induced cell cycle regulation; signaling pathway regulation PIK3C2A(INDUCES); SHC1(INDUCES); SHP-1(INDUCES); PIK3R1(INDUCES); PIK3CA(INDUCES) 1314164; 1330535; 1375321; 17403678; 25257795; 7774014; 7935391; 8195171; 8290276; 9452499 26 4 6 +Slc2a2 GLUT2 Membrane protein, integral; Membrane protein, multi-pass; Transporter; Transporter, SLC family P12336 25351 2q24 rat S501-p 451345 AAEFRKKsGSAPPRK activity, inhibited 8626492 1 1 0 Phosphorylation reduces the initial rate of 3-O-methyl glucose uptake. +WAS WASP Adaptor/scaffold; Motility/polarity/chemotaxis P42768 7454 Xp11.23 human Y291-p 447985 AETSKLIyDFIEDQG PBD activity, induced; molecular association, regulation cell motility, altered; cytoskeletal reorganization WIPF1(NOT_REPORTED) 10068673; 12235133; 17890224; 19808890 12 35 657 +Ptpra PTPRA EC 3.1.3.48; Membrane protein, integral; Motility/polarity/chemotaxis; PHOSPHATASE; Receptor protein phosphatase, tyrosine P18052 19262 2 F1|2 63.23 cM mouse Y825-p 447613 YIDAFSDyANFK___ molecular association, regulation; enzymatic activity, induced GRB2(INDUCES); Src(INDUCES) 12834342; 17507376; 7518772 17 85 2339 +ACAT1 ACAT1 ACETYLTRANSFERASE; Acetyltransferase; Amino Acid Metabolism - lysine degradation; Amino Acid Metabolism - tryptophan; Amino Acid Metabolism - valine, leucine and isoleucine degradation; Carbohydrate Metabolism - butanoate; Carbohydrate Metabolism - propanoate; Carbohydrate Metabolism - pyruvate; EC 2.3.1.9; Lipid Metabolism - fatty acid; Lipid Metabolism - synthesis and degradation of ketone bodies; Mitochondrial; Secondary Metabolites Metabolism - terpenoid backbone biosynthesis P24752 38 11q22.3 human Y407-p 10943316 HALKQGEyGLASICN Thiolase_C activity, induced; protein stabilization; protein conformation carcinogenesis, induced; cell growth, induced 27867011 2 1 0 tetramer accumulation +Mybl2 B-Myb DNA-binding; Motility/polarity/chemotaxis; Transcription factor P48972 17865 2 H2|2 84.0 cM mouse T490-p 452027 SQKVVVTtPLHRDKT Cmyb_C activity, induced 9840932 3 2 43 +HACE1 HACE1 EC 6.3.2.-; EC 6.3.2.19; Ligase; UBIQUITIN LIGASE; Ubiquitin conjugating system; Ubiquitin ligase Q8IYU2 57531 6q16.3 human S385-p 10940679 LMKNKRDsTEITSIL protein conformation 29362425 1 9 0 inhibits ubiquitination, S385 modulates HACE1 homo-oligomerization properties +STAR STAR Carrier; Lipid-binding; Mitochondrial P49675 6770 8p11.23 human S57-p 450440 NQVRRRSsLLGSRLE molecular association, regulation; protein conformation 14-3-3 sigma(INDUCES); 14-3-3 epsilon(INDUCES); 14-3-3 gamma(INDUCES) 32633081 5 1 1 +KRT8 K8 Cytoskeletal P05787 3856 12q13.13 human K472-ac 1983601 KIETRDGkLVSESSD cytoskeletal reorganization 18203277; 18983182 2 4 13 +LGR5 LGR5 GPCR, family 1; Membrane protein, integral; Membrane protein, multi-pass; Receptor, GPCR O75473 8549 12q21.1 human S861-p 27806301 SDDVEKQsCDSTQAL receptor internalization, induced 23439653 1 0 0 constitutive internalization. Sites S844, S848, S851 and S854 may secondarily contribute to LGR5 internalization. +FSCN1 fascin Actin-binding; Cytoskeletal; Motility/polarity/chemotaxis Q16658 6624 7p22.1 human S274-p 63292500 AANERNVsTRQGMDL Fascin cell growth, inhibited; cytoskeletal reorganization 28251354 1 0 0 negatively regulates esophageal squamous cancer cells (ESCCs) behavior and ?lopodia formation +Tnni3 TNNI3 Actin-binding; Motility/polarity/chemotaxis; Motor P23693 29248 1q12 rat S45-p 450691 KKSKISAsRKLQLKT cell motility, altered 16936010 22 3 0 heart contractility and relaxation +KIF2A KIF2A Microtubule-binding; Motor O00139 3796 5q12.1 human T97-p 27451648 KIVKNRRtVASIKND intracellular localization cell cycle regulation; cytoskeletal reorganization 23960144 1 4 4 +RECQL4 RECQL4 EC 3.6.4.12; Helicase O94761 9401 8q24.3 human K386-ac 7106306 WKQKWRKkGECFGGG intracellular localization 19299466 1 0 0 accumulates in the cytoplasm +EGFR EGFR EC 2.7.10.1; KINASE; Kinase, protein; Membrane protein, integral; Oncoprotein; Protein kinase, TK; Protein kinase, tyrosine (receptor) P00533 1956 7p11.2 human K1182-ac 14991104 DFFPKEAkPNGIFKG receptor internalization, induced; phosphorylation endocytosis, induced; signaling pathway regulation 20513767 1 1 0 induces AKT phosphorylation and hence ERK1/2 signaling +NLRP3 NLRP3 Inhibitor Q96P20 114548 1q44 human S5-p 38492201 ___MKMAsTRCKLAR protein stabilization; molecular association, regulation; protein conformation; activity, inhibited signaling pathway regulation NLRP3(DISRUPTS); PYCARD(DISRUPTS) 28465465; 32929041 4 1 0 inhibits ubiquitination, inhibits NLRP3 oligomerization +APBA3 APBA3 Motility/polarity/chemotaxis O96018 9546 19p13.3 human T5-p 29668010 ___MDFPtISRSPSG molecular association, regulation cell growth, induced HIF1AN(INDUCES) 24164895 1 1 0 +LIN28A LIN28A Nucleolus; RNA-binding; Translation Q9H9Z2 79727 1p36.11 human S200-p 7231811 EEEEEIHsPTLLPEA activity, inhibited cell growth, inhibited; cell differentiation, induced 28179426 1 5 0 increase in let7a and let7g miRNA and decrease in cyclin D1 levels +Rph3a rabphilin 3A Vesicle P47709 171039 12q16 rat S274-p 455801 QGLRRANsVQASRPA intracellular localization 11466418 3 5 0 +Hmga2 HMGA2 DNA-binding; Oncoprotein P52927 15364 10 D2|10 67.94 cM mouse S44-p 4033091 QEPTCEPsPKRPRGR molecular association, regulation; protein conformation DNA(DISRUPTS) 10636877 1 34 2 +Ffar4 GPR120 GPCR, family 1; Lipid-binding; Membrane protein, integral; Membrane protein, multi-pass; Receptor, GPCR Q7TMA4 107221 19|19 C2 mouse S357-p 31014806 SVRRNDLsVISS___ receptor internalization, induced; molecular association, regulation ARR3(INDUCES) 26873857 3 1 0 +MAML1 MAML1 Transcription, coactivator/corepressor Q92585 9794 5q35.3 human K189-ac 206216901 GLDSLNKkRLADSSL molecular association, regulation Notch 1(INDUCES) 28625977 1 0 0 +Stxbp5 STXBP5 Vesicle Q8K400 78808 10|10 A1 mouse K766-sm 31957309 LSLPTDLkPDLDVKD neural plasticity 24614299 1 0 0 +BMF BMF Apoptosis; Cytoskeletal Q96LC9 90427 15q15.1 human S77-p 22999100 TQTLSPAsPSQGVML BMF apoptosis, inhibited 22258404 2 0 0 +SREBF1 SREBP-1 DNA-binding; Membrane protein, integral; Membrane protein, multi-pass; Transcription factor P36956 6720 17p11.2 human K333-ac 459102 TAHNAIEkRYRSSIN HLH protein stabilization; ubiquitination transcription, induced 12640139; 20595232 2 0 0 +Rplp2 RPLP2 Ribosomal; Translation P02401 140662 1q41 rat S102-p 454319 KDEKKEEsEESDDDM Ribosomal_60s activity, induced translation, altered 12379128 3 120 344 +PXN PXN Adaptor/scaffold; Cell adhesion; Cytoskeletal; Motility/polarity/chemotaxis P49023 5829 12q24.23 human Y88-p 448909 PQSSSPVyGSSAKTS Paxillin carcinogenesis, induced; cell motility, induced; cell growth, induced; cytoskeletal reorganization 35297710 6 48 1343 +AR AR DNA-binding; Nuclear receptor; Transcription factor P10275 367 Xq12 human K521-sm 2793918 YPSPTCVkSEMGPWM molecular association, regulation; activity, inhibited carcinogenesis, induced; transcription, induced; transcription, inhibited RAI17(INDUCES) DNA(INDUCES) 11121022; 12177000; 14609956; 15031320; 32948192 7 0 0 chromatin enrichment independent of ligand activation +MET Met EC 2.7.10.1; KINASE; Kinase, protein; Membrane protein, integral; Oncoprotein; Protein kinase, TK; Protein kinase, tyrosine (receptor) P08581 4233 7q31.2 human Y1235-p 448471 DMYDKEYySVHNKTG PK_Tyr_Ser-Thr activity, induced; protein conformation; phosphorylation; enzymatic activity, induced carcinogenesis, induced; cell motility, induced; cell motility, altered; apoptosis, inhibited; signaling pathway regulation; cell growth, altered PTP1B(INDUCES); PTPN2(INDUCES) 10490849; 12746450; 14559966; 1655790; 18819921; 21247903; 21918175; 22081023; 24634221; 7961992; 8302603 52 16 442 +CALD1 Caldesmon Actin-binding Q28708 100009077 rabbit S529-p 448466 QSVDKVTsPTKV___ molecular association, regulation; protein conformation HSP27(INDUCES); TPM1(DISRUPTS) 16627824 19 19 0 +SEPTIN5 SEPT5 iso2 Cell cycle regulation; Cytoskeletal; Hydrolase; Vesicle Q99719-2 5413 22q11.21 human S17-p 475075 RLVEQLLsPRTQAQR molecular association, regulation STX1A(DISRUPTS) 17224448 2 7 2 +MAP4 MAP4 Cytoskeletal; Motility/polarity/chemotaxis ACK86564 100302596 cat S924-p 1210622 NVRSKVGsTENIKHQ Tubulin-binding cytoskeletal reorganization 20436166 4 53 41 +LRATD1 LRATD1 Unknown function Q96KN4 151354 2p24.3 human S38-p 469624 VGVAYFFsDDEEDLD cell motility, altered; cytoskeletal reorganization 16820875 2 0 0 +Glp1r GLP1R GPCR, family 2; Membrane protein, integral; Membrane protein, multi-pass; Receptor, GPCR P32301 25051 20p12 rat S441-p 451368 KPLKCPTsSVSSGAT receptor desensitization, altered 8702711 1 0 0 +NR1I2 PXR DNA-binding; Nuclear receptor O75469 8856 3q13.33 human T133-p 30259803 KRKKSERtGTQPLGV molecular association, regulation DNA(DISRUPTS) 24184507 1 2 0 +DENND3 DENND3 GEF; GEF, Rab A2RUS2 22898 8q24.3 human S472-p 7997148 THRRMVVsMPNLQDI molecular association, regulation 14-3-3 beta(INDUCES) 25925668 2 6 11 enhances its GEF activity toward Rab12 +PIP4K2C PIP4K2C Carbohydrate Metabolism - inositol phosphate; EC 2.7.1.149; Endoplasmic reticulum; Kinase, lipid; Motility/polarity/chemotaxis Q8TBX8 79837 12q13.3 human S324-p 34431501 GPPALVGsYGTSPEG PIP5K intracellular localization; phosphorylation cell growth, inhibited; signaling pathway regulation 25372051 1 1 0 inhibits expression of phosphorylated p70S6K and S6, inhibits mTORC1 signaling, regulates cell size +DTNBP1 DTNBP1 Vesicle Q96EV8 84062 6p22.3 human S297-p 9320776 ELRAKPPsSSSTCTD Dysbindin protein degradation; ubiquitination cell growth, inhibited; transcription, inhibited 30062698 1 3 2 phosphorylation inhibits cofilin transcription and does not reduce surface NR2A levels +PGR PR DNA-binding; Nuclear receptor; Transcription factor P06401 5241 11q22.1 human S294-p 447987 APMAPGRsPLATTVM Prog_receptor sumoylation; protein degradation; ubiquitination; intracellular localization carcinogenesis, altered; transcription, induced; cell adhesion, altered; cell growth, altered 10655479; 12554776; 17173941; 17717077; 19706513; 26577046; 27852068; 28412963 21 3 0 +CD19 CD19 Cell surface; Membrane protein, integral P15391 930 16p11.2 human Y409-p 447935 EEEEGEGyEEPDSEE activity, induced; molecular association, regulation; phosphorylation PLCG2(INDUCES); VAV1(INDUCES) 10706702 2 0 0 ERK2 phosphorylation; Ca(2+) influx +Trpv5 TRPV5 Channel, cation; Membrane protein, integral; Membrane protein, multi-pass; Motility/polarity/chemotaxis Q9XSM3 rabbit S299-p 470108 FLELVVSsKKREARQ activity, induced; intracellular localization 18305097; 19157541 3 0 0 CaR-dependent channel activation; inhibits caveolar endocytosis of TRPV5 +SLC26A4 SLC26A4 Membrane protein, integral; Membrane protein, multi-pass; Transporter; Transporter, SLC family O43511 5172 7q22.3 human T717-p 22561300 DDNIRKDtFFLTVHD STAS intracellular localization 22109890 1 0 0 +EGFR EGFR EC 2.7.10.1; KINASE; Kinase, protein; Membrane protein, integral; Oncoprotein; Protein kinase, TK; Protein kinase, tyrosine (receptor) P00533 1956 7p11.2 human Y1172-p 448059 ISLDNPDyQQDFFPK protein degradation; molecular association, regulation; receptor internalization, altered; phosphorylation; enzymatic activity, induced carcinogenesis, induced; cell motility, induced; signaling pathway regulation; cell growth, altered RASA1(INDUCES); GRB2(INDUCES); VAV2(INDUCES); SHP-1(INDUCES); DOK2(INDUCES); DOK1(INDUCES); EGFR(INDUCES); SHC1(INDUCES) 10508618; 12454019; 12842895; 1314835; 15476828; 16729043; 2022651; 2022652; 24430869; 26290602; 28102297; 3263271; 34367939; 7506413; 8408058; 9733788 44 60 967 triggers AKT, ERK phosphorylation and thus induces PI3K-AKT and MAPK-ERK signaling +USP8 USP8 DEUBIQUITINASE; EC 3.4.19.12; Protease; Ubiquitin conjugating system; Ubiquitin-specific protease P40818 9101 15q21.2 human S718-p 454338 SKLKRSYsSPDITQA molecular association, regulation; enzymatic activity, inhibited cell cycle regulation 14-3-3 beta(INDUCES); 14-3-3 sigma(INDUCES); 14-3-3 epsilon(INDUCES) 17720156; 26214742; 29880877 4 71 26 USP8 is activated in M phase and has less 14-3-3s associated; stabilization of RTKs +DLG4 PSD-95 Adaptor/scaffold P78352 1742 17p13.1 human S73-p 471390 ITLERGNsGLGFSIA PDZ molecular association, regulation NMDAR1(DISRUPTS) 25393018 6 4 0 in mature synapses; CaMKII was unable to trigger the complex separation in the presence of a calpain inhibitor. +FANCE FANCE DNA repair, damage Q9HB96 2178 6p21.31 human S374-p 476782 LFLGRILsLTSSASR FA_FANCE protein degradation; molecular association, regulation; intracellular localization FANCD2(INDUCES) 17296736 1 0 2 required for mitomycin C resistance +MYO6 MYO6 Actin-binding; Motility/polarity/chemotaxis; Motor Q9UM54 4646 6q14.1 human T405-p 449089 TAGGTKGtVIKVPLK Myosin_head intracellular localization 28348208 4 14 1 recruited to Salmonella-induced membrane ruffles +NFAT5 NFAT5 Transcription factor O94916 10725 16q22.1 human T135-p 469161 TVQQHPStPKRHTVL intracellular localization transcription, induced 21209322 1 5 9 +Kdr VEGFR2 EC 2.7.10.1; KINASE; Kinase, protein; Membrane protein, integral; Protein kinase, TK; Protein kinase, tyrosine (receptor) P35918 16542 5 C3.3|5 40.23 cM mouse S1188-p 18755300 TLSMEEDsGLSLPTS activity, induced; protein degradation; molecular association, regulation; ubiquitination BTRC(INDUCES) 21402774 1 0 0 +SLC25A5 SLC25A5 Membrane protein, integral; Membrane protein, multi-pass; Mitochondrial; Transporter; Transporter, SLC family P05141 292 Xq24 human T107-p 1876923700 LGGVDKRtQFWLYFA protein stabilization; acetylation apoptosis, inhibited 32194820 1 1 0 reciprocal regulation of T107, K105 +RAD51 RAD51 DNA repair, damage; Mitochondrial Q06609 5888 15q15.1 human K70-sm 1879760605 IKGISEAkADKILAE molecular association, regulation DNA repair, induced BRCA2(INDUCES) 35061896 2 0 0 RAD51 SUMOylation is required for HR-mediated DSB repair, GFP-TOPORS-WT restored the interaction between RAD51 and BRCA2, but the T515A mutant restored to a lesser degree +Cebpb C/EBP-beta DNA-binding; Motility/polarity/chemotaxis; Transcription factor P21272 24253 3q42 rat S240-p 452156 NNIAVRKsRDKAKMR bZIP_2 molecular association, regulation transcription, altered DNA(DISRUPTS) 8200992 3 0 0 +RELA NFkB-p65 DNA-binding; Nuclear receptor co-regulator; Transcription factor Q04206 5970 11q13.1 human K122-ac 458970 NLGIQCVkKRDLEQA RHD_DNA_bind activity, induced; molecular association, regulation; intracellular localization transcription, inhibited DNA(DISRUPTS) 12419806; 23087373; 23740527 6 2 24 inhibits inflammatory gene expression; induces beta-amyloid cytokine production, neurotoxicity, and neuronal cell death (inhibited by compound 11) +VCP VCP Chaperone; DNA repair, damage; EC 3.6.4.6; Endoplasmic reticulum; Hydrolase P55072 7415 9p13.3 human S784-p 456210 NQGGAGPsQGSGGGT protein degradation; molecular association, regulation; ubiquitination; intracellular localization; phosphorylation DNA repair, induced; carcinogenesis, inhibited; signaling pathway regulation NPL4(DISRUPTS); UFD1L(DISRUPTS) DNA(DISRUPTS) 16140914; 32521270; 34680224 3 4 33 +ELAVL1 HuR RNA-binding Q15717 1994 19p13.2 human S88-p 474552 LNGLRLQsKTIKVSY RRM_1 protein degradation; molecular association, regulation RNA splicing, induced; RNA stability, altered RNA(INDUCES); RNA(DISRUPTS) 17317627; 24865968; 32929216 4 0 0 +SLX4 SLX4 DNA repair, damage; Deoxyribonuclease Q8IY92 84464 16p13.3 human T1561-p 1880104208 LPPKVPItPMPQYSI molecular association, regulation; protein conformation MUS81(INDUCES) 36288699 1 1 0 +CSNK2B CK2B KINASE; Protein kinase, regulatory subunit P67870 1460 6p21.33 human S2-p 447646 ______MsSSEEVSW protein stabilization; enzymatic activity, induced CK2B(INDUCES) 12032843; 8269941 3 12 0 +NFE2L2 NRF2 DNA-binding; Transcription factor Q16236 4780 2q31.2 human S40-p 450082 SREVFDFsQRRKEYE activity, induced; protein stabilization; molecular association, regulation; intracellular localization carcinogenesis, induced; carcinogenesis, inhibited; apoptosis, inhibited; cell motility, inhibited; autophagy, inhibited; transcription, induced HMOX1(DISRUPTS); KEAP1(DISRUPTS); LANA(INDUCES); SIAH2(INDUCES) DNA(INDUCES) 12700136; 23645672; 25107906; 25236495; 25340789; 25505069; 26845617; 27517753; 33403569; 36240204; 36458309 33 0 0 +Tdg TDG DNA repair, damage; EC 3.2.2.29; Hydrolase; Nuclear receptor co-regulator P56581 21665 10 C1|10 39.72 cM mouse S96-p 11509301 KPATSKKsGKSTKSK molecular association, regulation; acetylation DNA repair, induced DNA(INDUCES) 19966277 1 0 1 inhibits acetylation at other sites +RPL23A RPL23A Ribosomal; Translation P62750 6147 17q11.2 human K123-ub 22251147 LYDIDVAkVNTLIRP Ribosomal_L23 protein degradation; ubiquitination transcription, altered 35637966 1 4 0 HERC3 could control protein expression and ubiquitination of c-Myc/p21 via RPL23A +Nphs1 NPHS1 Cell adhesion; Immunoglobulin superfamily; Membrane protein, integral Q9R044 64563 1q21 rat Y1127-p 6377602 EDRIRNEyEESQWTG molecular association, regulation; phosphorylation SHP-1(INDUCES) 25404734 2 0 0 +KCNA2 Kv1.2 Channel, potassium; Membrane protein, integral; Membrane protein, multi-pass P16389 3737 1p13.3 human Y417-p 455553 VSNFNYFyHRETEGE Ion_trans molecular association, regulation Cortactin(DISRUPTS) 12151401 1 0 0 +HCLS1 HS1 Adaptor/scaffold; Motility/polarity/chemotaxis P14317 3059 3q13.33 human Y397-p 451636 EDEPEGDyEEVLEPE activity, induced; molecular association, regulation; intracellular localization apoptosis, altered; cell motility, induced; cell adhesion, altered; cytoskeletal reorganization; transcription, altered ARPC2(INDUCES); VAV1(INDUCES) 16782030; 18587398; 22679023; 25723543; 9104825 9 1 7 +BORA BORA Activator Q6PGQ7 79866 13q21.33 human S137-p 9320596 CTNINSDsPVGKKLT BORA_N molecular association, regulation cell cycle regulation PLK1(INDUCES) 27068477 1 6 1 +DEPTOR DEPTOR Apoptosis Q8TB45 64798 8q24.12 human S299-p 4723878 SSPTLSSsPPVLCNP protein degradation; molecular association, regulation carcinogenesis, induced; apoptosis, inhibited; signaling pathway regulation BTRC(INDUCES); mTOR(DISRUPTS) 19446321; 22017875; 22017877 3 6 1 PI3K-Akt signaling +EEF1A1 EEF1A1 Nucleolus; Translation; Translation elongation P68104 1915 6q13 human K55-m2 3898705 EMGKGSFkYAWVLDK GTP_EFTU molecular association, regulation; enzymatic activity, induced carcinogenesis, induced; cell motility, induced; cell growth, induced; apoptosis, inhibited; translation, induced L3MBTL iso4(INDUCES) 23583077; 30612740; 32347192 4 7 11 +ERBB4 HER4 EC 2.7.10.1; KINASE; Kinase, protein; Membrane protein, integral; Protein kinase, TK; Protein kinase, tyrosine (receptor) Q15303 2066 2q34 human T699-p 9430151 TELVEPLtPSGTAPN enzymatic activity, inhibited; phosphorylation signaling pathway regulation 31053301 1 3 8 downregulates phosphorylation of Y1284; MEK-ERK pathway-dependent feedback inhibition of HER4 activation +Becn1 beclin 1 Adaptor/scaffold; Autophagy; Membrane protein, peripheral O88597 56208 11|11 D mouse K115-ub 14991107 ENLSRRLkVTGDLFD BH3 cell differentiation, induced 31074883 2 0 0 osteoclast differentiation, chondrocyte differentiation is impaired in Beclin1 cKO mice +Becn1 beclin 1 Adaptor/scaffold; Autophagy; Membrane protein, peripheral O88597 56208 11|11 D mouse S94-p 472002 MSTESANsFTLIGEA autophagy, induced 34287052 4 2 1 +Mapt Tau ACETYLTRANSFERASE; Acetyltransferase; Cytoskeletal P10637 17762 11 67.79 cM|11 E1 mouse S648-p 449104 RVQSKIGsLDNITHV Tubulin-binding protein degradation 17573348 35 24 0 LKB1-MARK signaling causes proteasome-mediated degradation of Tau. +GRIK2 GluR6 Channel, calcium; Channel, ligand-gated; Membrane protein, integral; Membrane protein, multi-pass Q13002 2898 6q16.3 human K886-sm 12004405 PQAPVIVkTEEVINM sumoylation; receptor internalization, induced; intracellular localization; phosphorylation; palmitoylation neural plasticity; endocytosis, altered 22522402; 37868810 4 0 0 palmitoylation maintains surface expression and regulates agonist -induced internalisation; long-term depression (LTD) of KAR receptor mediated synaptic transmission +MLH1 MLH1 Cell cycle regulation; DNA repair, damage; Tumor suppressor P40692 4292 3p22.2 human S477-p 480003 RKRHREDsDVEMVED protein stabilization; intracellular localization; protein conformation carcinogenesis, induced; DNA repair, inhibited 30136313; 35326704 3 22 191 +Oprd1 DOR-1 GPCR, family 1; Membrane protein, integral; Membrane protein, multi-pass; Receptor, GPCR P32300 18386 4 D2.3|4 64.78 cM mouse T353-p 3146600 RRPRQATtRERVTAC protein degradation; intracellular localization; receptor internalization, altered 10701775; 21220103 2 0 0 +MAPK14 P38A EC 2.7.11.24; KINASE; Kinase, protein; Protein kinase, CMGC; Protein kinase, Ser/Thr (non-receptor) Q16539 1432 6p21.31 human Y182-p 447971 TDDEMTGyVATRWYR Pkinase activity, induced; phosphorylation; enzymatic activity, induced cell cycle regulation; carcinogenesis, induced; apoptosis, altered; apoptosis, induced; signaling pathway regulation; cell growth, induced; cell motility, altered; transcription, inhibited; carcinogenesis, inhibited; cell growth, inhibited; transcription, induced; autophagy, induced; cell differentiation, induced; cytoskeletal reorganization; cell adhesion, altered; autophagy, inhibited P38A(INDUCES) 10201954; 10867021; 11994493; 15944157; 16966330; 17126298; 17438131; 17548358; 18047584; 18560558; 19336399; 21177868; 21878628; 22039048; 33676898; 33685990; 34048499; 34148056; 34209868; 34995286; 35189144; 35569509; 35849202; 36219392; 36289618; 8622669 410 123 3683 autoamplifcation of NFAT-c1, which promotes osteoclast differentiation, suppressed by MLN4924 +Npy1r NPY1R GPCR, family 1; Membrane protein, integral; Membrane protein, multi-pass; Receptor, GPCR P21555 29358 16p14 rat S367-p 2815301 KTSLKQAsPVAFKKI receptor internalization, altered 15576634 1 7 0 may be an artifact of the truncation mutants +Rps6 S6 Translation P62754 20104 4|4 C4 mouse S236-p 448093 AKRRRLSsLRASTSK carcinogenesis, induced; carcinogenesis, inhibited; signaling pathway regulation; neural plasticity; cell growth, induced; autophagy, inhibited; translation, induced; transcription, inhibited 18851840; 23361300; 33826903; 34342159; 34426542; 34695513; 35428325; 37068088 239 72 1124 Promotes axonal regeneration in the nervous systems +Eif4ebp1 4E-BP1 Translation; Translation initiation Q62622 116636 16q12.3 rat T69-p 447528 RNSPVAKtPPKDLPT eIF_4EBP molecular association, regulation; phosphorylation translation, altered EIF4E(INDUCES); EIF4E(DISRUPTS) 10779345; 20736160; 9806882 55 57 9 +NEK9 NEK9 Autophagy; EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, Other; Protein kinase, Ser/Thr (non-receptor) Q8TD19 91754 14q24.3 human S869-p 7322159 KPQVEASsPRLNPAV molecular association, regulation; phosphorylation; enzymatic activity, induced PLK1(INDUCES) 21642957 1 15 2 phosphorylation of the priming site induces phosphorylation at T210 +CHUK IKKA EC 2.7.11.10; KINASE; Kinase, protein; Protein kinase, Other; Protein kinase, Ser/Thr (non-receptor) O15111 1147 10q24.31 human S180-p 447779 DQGSLCTsFVGTLQY Pkinase activity, induced; enzymatic activity, induced chromatin organization, altered; cell motility, altered; transcription, induced 17880897; 18950704; 19073147; 33883226 44 0 0 +P2RX3 P2X3 Channel, ligand-gated; Membrane protein, integral; Membrane protein, multi-pass P56373 5024 11q12.1 human S178-p 458896 FTIFIKNsIRFPLFN P2X_receptor receptor desensitization, altered 16226373 1 0 0 +PHF5A PHF5A RNA splicing; RNA-binding Q7RTV0 84844 22q13.2 human K29-ac 1879864500 LCEKCDGkCVICDSY molecular association, regulation carcinogenesis, induced; RNA splicing, induced; cell growth, induced; transcription, induced; signaling pathway regulation SF3B1(INDUCES) 31054974 1 1 0 fraction of 11 genes were commonly changed in differentially expressed genes, upregulation of KDM3A expression and activates the Wnt signaling pathway in colorectal cancer +Lpp LPP Adaptor/scaffold; Cytoskeletal; Motility/polarity/chemotaxis Q8BFW7 210126 16|16 B1 mouse Y302-p 448949 GRYYEPYyAAGPSYG cell cycle regulation; cell motility, altered 18515860 2 25 526 +WNK4 WNK4 EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, Other; Protein kinase, Ser/Thr (non-receptor) Q96J92 65266 17q21.2 human S1217-p 5879855 PGIMRRNsLSGSSTG activity, induced 23054253; 23673010 5 11 9 BK channel activity induced; regulates NKCC2 activity +DNMT3A DNMT3A Amino Acid Metabolism - cysteine and methionine; EC 2.1.1.37; METHYLTRANSFERASE; Methyltransferase; Methyltransferase, DNA Q9Y6K1 1788 2p23.3 human S393-p 17548182 VCHDSDEsDTAKAVE methylation; intracellular localization; enzymatic activity, inhibited 25066127 1 4 0 decreases methylation of CpG +DRD2 DRD2 GPCR, family 1; Membrane protein, integral; Membrane protein, multi-pass; Receptor, GPCR P14416 1813 11q23.2 human S228-p 487432 KRVNTKRsSRAFRAH 7tm_1 receptor desensitization, induced 17869243 2 0 0 +GOT2 GOT2 Amino Acid Metabolism - alanine, aspartate and glutamate; Amino Acid Metabolism - arginine and proline; Amino Acid Metabolism - cysteine and methionine; Amino Acid Metabolism - phenylalanine; Amino Acid Metabolism - phenylalanine, tyrosine and tryptophan biosynthesis; Amino Acid Metabolism - tyrosine; EC 2.6.1.1; EC 2.6.1.7; Mitochondrial; Transferase P00505 2806 16q21 human K185-ac 466484 GYRYYDPkTCGFDFT Aminotran_1_2 molecular association, regulation; phosphorylation carcinogenesis, induced; cell growth, induced; apoptosis, inhibited MDH2(INDUCES) 25755250 1 4 2 induces H3 phosphorylation +SPOP SPOP UBIQUITIN LIGASE; Ubiquitin ligase O43791 8405 17q21.33 human S119-p 1874115101 EETKAMEsQRAYRFV MATH molecular association, regulation; phosphorylation DNA repair, induced; carcinogenesis, inhibited; cell growth, inhibited; signaling pathway regulation HIPK2(INDUCES) 34133717 1 0 0 induces HIPK2-HP1 signaling pathway by inducing HP1 phosphorylation +RPS6KA4 MSK2 EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, AGC; Protein kinase, Ser/Thr (non-receptor) O75676 8986 11q13.1 human S324-p 11489900 PFRPQIRsELDVGNF Pkinase_C phosphorylation; enzymatic activity, induced 19933278 1 0 0 stimulates phosphorylation of S196 +IRF3 IRF3 DNA-binding; Transcription factor Q14653 3661 19q13.33 human S405-p 449032 SHPLSLTsDQYKAYL activity, induced; protein degradation; molecular association, regulation; intracellular localization; protein conformation; phosphorylation autophagy, induced; transcription, induced; transcription, altered CALCOCO2(INDUCES); CBP(INDUCES) 17526488; 18272581; 19153595; 25070846; 27992402; 37330913; 9566918 8 1 0 GPR108 and Smurf1 mediated degradation requires NDP52; NDP52-dependent autophagic degradation of phosphorylated IRF3; GPR108 interacts with Smurf1, followed by the recruitment of IRF3 during viral infection +POLI POLI DNA repair, damage; EC 2.7.7.7; Transferase Q9UNA4 11201 18q21.2 human K296-ub 22249756 FSPKILEkELGISVA protein degradation 26370087 1 3 0 +PKN1 PKN1 EC 2.7.11.13; KINASE; Kinase, protein; Protein kinase, AGC; Protein kinase, Ser/Thr (non-receptor) Q16512 5585 19p13.12 human T774-p 447835 GYGDRTStFCGTPEF Pkinase molecular association, regulation; enzymatic activity, induced cytoskeletal reorganization HADHB(INDUCES); HADHA(INDUCES); PDK1(INDUCES) 10753910; 10792047; 26296974 7 5 319 +VASP VASP Cytoskeletal; Motility/polarity/chemotaxis P50552 7408 19q13.32 human S322-p 469024 TTLPRMKsSSSVTTS intracellular localization cytoskeletal reorganization; cell motility, inhibited 23846685; 26336132 3 15 45 Increases Filopodia formation; patients with high expression of PKD2 showed an increase in relapse-freee survival. +Ceacam20 CEACAM20 Immunoglobulin superfamily; Membrane protein, integral Q9D2Z1 71601 7|7 A3 mouse Y570-p 41604101 LNSNHSLyCKITPSA transcription, induced 26195794 1 1 0 increase in IL-8 production +KCNK2 TREK-1 iso2 Channel, potassium; Membrane protein, integral; Membrane protein, multi-pass O95069-2 3776 1q41 human S300-p 456160 GDWLRVIsKKTKEEV activity, inhibited neural plasticity 33006141 4 0 0 +GSK3B GSK3B EC 2.7.11.1; EC 2.7.11.26; KINASE; Kinase, protein; Protein kinase, CMGC; Protein kinase, Ser/Thr (non-receptor) P49841 2932 3q13.33 human Y56-p 1867735501 DRPQEVSyTDTKVIG Pkinase activity, induced; ubiquitination carcinogenesis, inhibited; cell growth, inhibited; transcription, inhibited 30711629 1 1 0 decreases transcription of PDL1; inhibits TRAF6-mediated GSK3B ubiquitination +TWIST1 TWIST1 Cell development/differentiation; DNA-binding; Inhibitor; Transcription regulation Q15672 7291 7p21.1 human K73-ub 1883509402 PGSPAQGkRGKKSAG protein degradation cell growth, inhibited; cell motility, inhibited 36115849 1 0 0 +BACE1 BACE EC 3.4.23.46; Membrane protein, integral; Protease P56817 23621 11q23.3 human K307-ac 478255 KVFEAAVkSIKAASS Asp protein stabilization; intracellular localization 17425515 1 1 0 regulates translocation through secretory pathway +MCM4 MCM4 DNA replication; EC 3.6.4.12 P33991 4173 8q11.21 human S54-p 448667 ELQPMPTsPGVDLQS activity, inhibited 12714602 3 5 5 +PTPN5 STEP EC 3.1.3.48; Membrane protein, multi-pass; Motility/polarity/chemotaxis; PHOSPHATASE; Protein phosphatase, tyrosine (non-receptor) P54829 84867 11p15.1 human S184-p 51170600 PPEDRRQsVSRQPSF molecular association, regulation; enzymatic activity, inhibited ERK1(DISRUPTS); ERK2(DISRUPTS) 26574547 2 0 0 +FLII FLI Actin-binding; Nuclear receptor co-regulator Q13045 2314 17p11.2 human S64-p 1163832400 KLEHLSVsHNNLTTL LRR_8 molecular association, regulation autophagy, induced KHDRBS1(DISRUPTS) 29898994 1 0 0 +TSC1 TSC1 Motility/polarity/chemotaxis; Tumor suppressor Q92574 7248 9q34.13 human T310-p 478102 SYGCATStPYSTSRL Hamartin molecular association, regulation PLK1(INDUCES) 16339216 1 0 0 +MAP3K3 MEKK3 EC 2.7.11.25; KINASE; Kinase, protein; Protein kinase, STE; Protein kinase, Ser/Thr (non-receptor) Q99759 4215 17q23.3 human S520-p 12607406 RLQTICMsGTGMRSV Pkinase enzymatic activity, induced 20068038 2 1 0 essential for MEKK3-mediated IKK-beta/NFkB activation +Slc10a2 ASBT Membrane protein, integral; Membrane protein, multi-pass; Transporter Q62633 29500 16q12.5 rat S335-p 453445 NDMDPMPsFQETNKG protein degradation 15304498 2 1 0 +Cdk1 CDK1 Cell cycle regulation; EC 2.7.11.22; EC 2.7.11.23; KINASE; Kinase, protein; Motility/polarity/chemotaxis; Protein kinase, CMGC; Protein kinase, Ser/Thr (non-receptor) P11440 12534 10 B5.3|10 36.07 cM mouse T14-p 447608 IEKIGEGtYGVVYKG Pkinase enzymatic activity, inhibited cell cycle regulation 1655417 34 117 1764 +SPAG9 JIP4 Adaptor/scaffold; Cancer Testis Antigen (CTA) O60271 9043 17q21.33 human S730-p 453192 GSKQRSAsQSSLDKL enzymatic activity, inhibited 34319782 1 53 3 inhibits IAV polymerase activity thus producing an antiviral response +Sgk1 SGK1 EC 2.7.11.1; KINASE; Kinase, protein; Motility/polarity/chemotaxis; Protein kinase, AGC; Protein kinase, Ser/Thr (non-receptor) Q06226 29517 1p12 rat S421-p 448429 AEAFLGFsYAPPMDS Pkinase_C enzymatic activity, induced transcription, induced 10357815; 18088355 30 0 0 involved in spatial memory formation by increasing expression of zif268 in hippocampus, through phosphorylation of SRF S99 and CREB S133 +KIF13B KIF13B Microtubule-binding; Motor Q9NQT8 23303 8p12 human S1381-p 4691956 KLSRRSIsSPNVNRL molecular association, regulation; intracellular localization; protein conformation cell growth, inhibited; cytoskeletal reorganization 14-3-3 beta(INDUCES) 20194617 1 46 14 regulates intramolecular interaction +Ccdc88a girdin Actin-binding Q5SNZ0 108686 11|11 A3.3 mouse S1417-p 456477 INRERQKsLTLTPTR neural plasticity; cell motility, induced; cell growth, induced 25378165; 25732845; 26393439 9 18 1 enhances proliferative and migratory responses in fibroblasts, facilitates tumor growth; regulates cardiac repair processes after myocardial infarction and prevents mortality due to cardiac rupture +DCTN1 dynactin 1 Microtubule-binding; Motility/polarity/chemotaxis; Motor Q14203 1639 2p13.1 human S179-p 15512801 SASAGELsSSEPSTP protein stabilization; molecular association, regulation; intracellular localization cell cycle regulation; carcinogenesis, induced; apoptosis, inhibited; transcription, altered 20679239; 23661607 2 0 0 induce AR stabilization and nuclear translocation/accumulation; inhibits dynactin 1 interaction with microtubules +TRIM28 TIF1B EC 6.3.2.-; KINASE; Kinase, protein; Ligase; Nuclear receptor co-regulator; Protein kinase, atypical; SUMO LIGASE; SUMO ligase; Transcription, coactivator/corepressor; UBIQUITIN LIGASE; Ubiquitin conjugating system; Ubiquitin ligase Q13263 10155 19q13.43 human K804-sm 2798311 NEAFGDTkFSAVLVE molecular association, regulation; acetylation; methylation cell growth, induced; transcription, inhibited CHD-3(INDUCES) 17079232; 17942393; 21642969; 31391303 5 4 0 loss of TF1B sumoylation induces dsRNA-activated IFN-mediated defenses that rely on RIG-I, MAVS, TBK1, and JAK1 transcription, SUMOylated TIF1B Is required to support efficient virus replication +KHDC3L KHDC3L Cell cycle regulation Q587J8 154288 6q13 human T145-p 1673970100 IEVREAGtQRSVEVR activity, induced; molecular association, regulation DNA repair, induced; cell growth, induced PARP1(INDUCES) 31609975 1 0 0 +CYLD CYLD DEUBIQUITINASE; EC 3.4.19.12; Protease; Tumor suppressor; Ubiquitin conjugating system; Ubiquitin-specific protease Q9NQC7 1540 16q12.1 human S432-p 12173909 KMPNTNGsIGHSPLS CYLD_phos_site ubiquitination 15870263 1 0 0 induces ubiquitination of TRAF2 +POLI POLI DNA repair, damage; EC 2.7.7.7; Transferase Q9UNA4 11201 18q21.2 human K308-ub 21181890 SVAQRIQkLSFGEDN protein degradation 26370087 1 3 0 +Ptpn11 SHP-2 EC 3.1.3.48; Motility/polarity/chemotaxis; PHOSPHATASE; Protein phosphatase, tyrosine (non-receptor) P35235 19247 5|5 F mouse Y279-p 474206 ENKNKNRyKNILPFD Y_phosphatase phosphorylation; enzymatic activity, induced cell cycle regulation 18827006 1 6 66 +Krt17 K17 Cytoskeletal Q9QWL7 16667 11 D|11 63.44 cM mouse T9-p 464290 TTTIRQFtSSSSIKG molecular association, regulation cell cycle regulation 14-3-3 sigma(NOT_REPORTED) 16710422 1 0 0 Mutation of T8 and S43 (to alanine) causes reduced phosphorylation of Akt S473 and p70S6K T389. +Map2 MAP2 iso3 Cytoskeletal; Motility/polarity/chemotaxis P15146-3 25595 9q32 rat K396-ac 62495508 VPGGGNVkIDSQKLN cytoskeletal reorganization 28002468 1 1 0 +RAB10 RAB10 G protein; G protein, monomeric; G protein, monomeric, Rab P61026 10890 2p23.3 human T73-p 471953 AGQERFHtITTSYYR Ras autophagy, inhibited 34515301 18 13 13 +HSP90AA1 HSP90A Chaperone; Heat shock protein P07900 3320 14q32.31 human T115-p 13256102 GTIAKSGtKAFMEAL HATPase_c molecular association, regulation; enzymatic activity, inhibited; protein conformation cell cycle regulation CDC37(DISRUPTS); TTK(INDUCES); PKCG(DISRUPTS); AHSA1(INDUCES); HER2(INDUCES) 24117238; 26804907 2 0 0 +BBC3 PUMA Apoptosis; Mitochondrial Q9BXH1 27113 19q13.32 human S106-p 18610002 LAEQHLEsPVPSAPG PUMA molecular association, regulation; intracellular localization MPC1(INDUCES) 30712844 2 0 0 PUMA interacts with MPC and distrupts the oligomerization of MPC1 and MPC2 +MARK2 MARK2 EC 2.7.11.1; EC 2.7.11.26; KINASE; Kinase, protein; Protein kinase, CAMK; Protein kinase, Ser/Thr (non-receptor) Q7KZI7 2011 11q13.1 human T596-p 453427 RGVSSRStFHAGQLR molecular association, regulation; intracellular localization; enzymatic activity, inhibited; phosphorylation; enzymatic activity, induced translation, induced; signaling pathway regulation 14-3-3 beta(INDUCES) 15084291; 15324659; 19011111; 33705388 5 19 1 induces elF2 phosphorylation and hence the PKCd-MARK2-eIF2a signaling pathway +DUSP6 DUSP6 EC 3.1.3.16; EC 3.1.3.48; Motility/polarity/chemotaxis; PHOSPHATASE; Protein phosphatase, dual-specificity Q16828 1848 12q21.33 human S174-p 5938001 LGGLRISsDSSSDIE protein degradation 19106095 1 0 0 +NPM1 NPM1 Nucleolus; Oncoprotein; RNA-binding; Translation P06748 4869 5q35.1 human K212-ac 466414 QKSNQNGkDSKPSST molecular association, regulation; intracellular localization transcription, altered H3(INDUCES) 19581289 1 5 31 K212/215/229/230/257/267/292R mutant +HEXIM1 HEXIM1 Motility/polarity/chemotaxis; Transcription factor O94992 10614 17q21.31 human S158-p 25680402 KKHRRRPsKKKRHWK molecular association, regulation; activity, inhibited transcription, induced BCDIN3(DISRUPTS); CHD-4(DISRUPTS) RNA(DISRUPTS) 22821562; 31183407 2 0 0 promotes cystogenesis of kidney cells; inctivated ability to inhibit P-TEFb, increased levels of free P-TEFb in cells +RDX Radixin Cytoskeletal; Motility/polarity/chemotaxis P35241 5962 11q22.3 human T564-p 448374 AGRDKYKtLRQIRQG ERM_C intracellular localization; activity, inhibited; phosphorylation cytoskeletal reorganization 25799996; 33836044 21 7 16 pERM in the retraction fibers; inhibits Rho activity, regulates MLC2 phosphorylation +SMURF2 SMURF2 EC 6.3.2.-; EC 6.3.2.19; Ligase; UBIQUITIN LIGASE; Ubiquitin conjugating system; Ubiquitin ligase Q9HAU4 64750 17q23.3-q24.1 human K369-sm 52415800 CLTVPRYkRDLVQKL signaling pathway regulation 26679521 2 0 0 regulation of TGF-beta induced epithelial-mesenchymal transition +DDB2 DDB2 DNA repair, damage Q92466 1643 11p11.2 human K35-ub 1876931106 LELEPEAkKLCAKGS DNA repair, induced 32789493 1 1 0 SIRT6 as a critical factor in the regulation of the process of UV-induced DNA damage repair +HNF4A HNF4 alpha DNA-binding; Nuclear receptor; Transcription factor P41235 3172 20q13.12 human Y288-p 22996303 IDDNEYAyLKAIIFF Hormone_recep protein degradation; intracellular localization; phosphorylation transcription, inhibited 22308320 1 1 0 reduced nuclear localization and protein stability; multistep phosphorylation by Src, phosphorylating Y23 first, which interacts with the Src SH2 domain, followed by phosphorylation of Y286, Y288 +CASR CaR GPCR, family 3; Membrane protein, integral; Membrane protein, multi-pass; Motility/polarity/chemotaxis; Receptor, GPCR P41180 846 3q13.33-q21.1 human S899-p 15507601 SNVSRKRsSSLGGST molecular association, regulation; intracellular localization 14-3-3 beta(INDUCES); 14-3-3 beta(DISRUPTS) 20798521; 26317416 2 0 1 +MYOD1 MyoD DNA-binding; RNA splicing; Transcription factor P15172 4654 11p15.1 human S201-p 40684505 SGDSDASsPRSNCSD Myf5 molecular association, regulation; activity, inhibited transcription, inhibited SUV39H1(INDUCES) DNA(INDUCES) 20026657 8 1 0 MyoD binding to SUV39H1 results in SUV39H1 binding to DNA. +Uso1 TAP Motility/polarity/chemotaxis; Vesicle P41542 56042 14p22 rat S940-p 450465 PVEEEDEsGDQEDDD Uso1_p115_C intracellular localization 14533739 3 69 42 phosphorylation of site increases association with Golgi membranes in vitro, but not in vivo +MYOD1 MyoD DNA-binding; RNA splicing; Transcription factor P15172 4654 11p15.1 human Y30-p 449872 FATTDDFyDDPCFDS Basic cell differentiation, inhibited; cell cycle regulation; DNA repair, induced; transcription, induced 28446595 3 0 0 30F mutant overides senescence-associated inhibition of the myogenic program +Atp6v1a ATP6V1A EC 3.6.3.14; Energy Metabolism - oxidative phosphorylation; Hydrolase P50516 11964 16|16 B4 mouse S175-p 14913505 LPPRNRGsVTYIAPP ATP-synt_ab_Xtn intracellular localization; enzymatic activity, induced cell motility, induced 20525692; 26911844 3 1 0 ATP6V1A subunit expression at the leading edge, extracellular acidification +DNAJC5 DNAJC5 Vesicle Q9H3Z4 80331 20q13.33 human S34-p 10407117 TSDDIKKsYRKLALK DnaJ molecular association, regulation apoptosis, inhibited HSP70(INDUCES) 29167402 1 1 1 maintain normal conformation of SNAP25, protect dopaminergic neurons +Pawr PAR-4 Apoptosis Q62627 64513 7q21 rat S223-p 476476 GRYKSTIsAPEEEIL ATG16 apoptosis, inhibited; transcription, induced 24457960 1 15 18 +KCNIP3 calsenilin Calcium-binding; Transcription factor Q9Y2W7 30818 2q11.1 human K90-sm 25336513 QAQTKFTkKELQSLY intracellular localization transcription, inhibited 21070824 1 0 0 +GRIA1 GluR1 Channel, calcium; Channel, ligand-gated; Membrane protein, integral; Membrane protein, multi-pass P42261 2890 5q33.2 human C829-pa 9486202 LVALIEFcYKSRSES molecular association, regulation; intracellular localization; phosphorylation EPB41L1(DISRUPTS) 19503082 1 0 0 depalmitoylation of C829 (aka C811) enhances GluR1 phosphorylation at S834 (aka S816) and S836 (aka S818); depalmitoylation of C829 (aka C811) enhances the interaction with EPB41L1 (4.1N) and receptor insertion into plasma membrane +Sv2a SV2A Membrane protein, integral; Membrane protein, multi-pass; Vesicle Q9JIS5 64051 3|3 F2.1 mouse S80-p 4779752 DEEEGGAsSDATEGH molecular association, regulation SYT1(INDUCES) 25673844 1 9 11 SV2A retrieval during SV endocytosis, Thr84 of SV2A is critical in promoting the interaction with synaptotagmin-1 +Cebpb C/EBP-beta DNA-binding; Motility/polarity/chemotaxis; Transcription factor P28033 12608 2 H3|2 87.58 cM mouse K39-ac 473550 DCLAYGAkAARAAPR cell differentiation, induced; transcription, induced 17110376; 18486321 4 0 0 +BCAR1 P130Cas Adaptor/scaffold; Motility/polarity/chemotaxis P56945 9564 16q23.1 human Y249-p 448721 APGPQDIyDVPPVRG carcinogenesis, induced; cell growth, induced; transcription, induced 26867768; 34192548 14 44 723 +CLASP2 CLASP2 Cytoskeletal; Motility/polarity/chemotaxis O75122 23122 3p22.3 human S507-p 481392 QGCSREAsPSRLSVA cytoskeletal reorganization 22467876 1 18 10 +PRDX1 PRDX1 EC 1.11.1.15; Nuclear receptor co-regulator; Oxidoreductase Q06830 5052 1p34.1 human T183-p 476233 GWKPGSDtIKPDVQK 1-cysPrx_C enzymatic activity, inhibited 23386615 1 5 0 +UBA52-RPS27A-UBB-UBC ubiquitin Ubiquitin-like modifier P62988 2p16 human K11-ub 486301 FVKTLTGkTITLEVE ubiquitin protein degradation; molecular association, regulation; ubiquitination autophagy, induced; transcription, induced; signaling pathway regulation LC3B(INDUCES); ubiquitin(INDUCES); Cezanne(INDUCES); PSMD5(INDUCES) 18613717; 31937588; 32076268; 33824312; 34017102; 36379251; 8576261 25 22 155 TRIM26 enhances TLRs-induced NF-kB and MAPK signaling.; polyubiquitylation at multiple sites including K120, and monoubiquitylation leads to activation of transcription, K11-linked and K11/K48-branched chains-active APC/C, accumulated at specific genes in mitotic hESCs co-occupied by WDR5 and TBP; BAP37 promotes ef?cient mitophagy +AMOT AMOT Q4VCS5 154796 Xq23 human T750-p 56589712 DMEGRIKtLHAQIIE Angiomotin_C molecular association, regulation; intracellular localization cell motility, induced YAP1(DISRUPTS) 27321186 1 0 0 induces YAP1 nuclear localization +GSTP1 GSTP1 EC 2.5.1.18; Other Amino Acids Metabolism - glutathione; Transferase; Xenobiotic Metabolism - drug metabolism - cytochrome P450; Xenobiotic Metabolism - metabolism by cytochrome P450 P09211 2950 11q13.2 human Y4-p 462289 ____MPPyTVVYFPV GST_N protein conformation; enzymatic activity, induced 19254954 2 1 6 +ADD1 ADD1 Cytoskeletal; Motility/polarity/chemotaxis P35611 118 4p16.3 human S481-p 451596 KEDGHRTsTSAVPNL intracellular localization 25978380 2 3 1 localized at cell-cell borders, Ca2+ depletion, reduced or complete absence of alpha-adducin and alpha-adducin (pSer481) at cell-cell-junctions +DDX5 DDX5 EC 3.6.4.13; Helicase; Nuclear receptor co-regulator; Nucleolus; RNA splicing; RNA-binding; Spliceosome P17844 1655 17q23.3 human R484-m2 27280649 DRGSGRSrGRGGMKD molecular association, regulation XRN2(INDUCES) 31267554 1 2 1 represses R-loops +Tsc2 TSC2 Cell cycle regulation; GAP; GAP, misc.; Nuclear receptor co-regulator; Tumor suppressor P49816 24855 10q12 rat T1203-p 19075303 EILVRRPtGNTSWLM signaling pathway regulation 21561859 1 0 0 activation of mTORC1 +BDKRB2 BKR2 GPCR, family 1; Membrane protein, integral; Membrane protein, multi-pass; Receptor, GPCR P30411 624 14q32.2 human Y332-p 451672 SCLNPLVyVIVGKRF 7tm_1; TM molecular association, regulation; receptor internalization, altered; intracellular localization 15161928 1 0 0 +ARHGEF2 ARHGEF2 GEF; GEF, Rac/Rho; Motility/polarity/chemotaxis Q92974 9181 1q22 human S960-p 467500 SRLSPPHsPRDFTRM molecular association, regulation; enzymatic activity, inhibited cell cycle regulation 14-3-3 zeta(INDUCES) 17488622 3 46 13 +MYBPC3 MYBPC3 Myosin-binding Q14896 4607 11p11.2 human S284-p 471080 AGGGRRIsDSHEDTG protein stabilization; intracellular localization cytoskeletal reorganization 20018870; 22281395 35 8 28 +SLFN12 SLFN12 Unknown function Q8IYM2 55106 17q12 human S573-p 1876351802 NDKKMFKsCRRLT__ enzymatic activity, inhibited RNA stability, induced 35104454 1 1 0 +HNRNPA0 hnRNP A0 RNA splicing; RNA-binding Q13151 10949 5q31.2 human S84-p 449874 VELKRAVsREDSARP molecular association, regulation; intracellular localization RNA(INDUCES) 26602816 2 9 2 association of p27Kip1 mRNA +LAT LAT iso2 Adaptor/scaffold; Membrane protein, integral O43561-2 27040 16p11.2 human Y226-p 448006 EEEGAPDyENLQELN LAT molecular association, regulation; phosphorylation cell differentiation, altered; signaling pathway regulation; transcription, altered GRB2(INDUCES); GADS(INDUCES); THEMIS(INDUCES); TSAd(INDUCES) 11395491; 12496416; 15029250; 23460737; 27896837; 30510001; 34161759 17 3 72 induces Erk and calcium signaling +MAPT Tau iso8 ACETYLTRANSFERASE; Acetyltransferase; Cytoskeletal P10636-8 4137 17q21.31 human S199-p 447927 GDRSGYSsPGSPGTP O-GlcNAc glycosylation; molecular association, regulation; intracellular localization; protein conformation; phosphorylation cytoskeletal reorganization WWOX(INDUCES); Fyn(DISRUPTS); Tau iso8(INDUCES); Tau(INDUCES) 15126504; 15190058; 15364924; 16115884; 16923168; 18725412; 19451179; 20550628; 24312574; 35857446 91 33 33 +TLR4 TLR4 Membrane protein, integral; Receptor, misc. O00206 7099 9q33.1 human Y680-p 478361 IYDAFVIySSQDEDW TIR molecular association, regulation; phosphorylation transcription, induced IRAK1(DISRUPTS); MYD88(DISRUPTS) 17392283 1 0 0 IRAK1 short form +Pkm PKM Carbohydrate Metabolism - glycolysis and gluconeogenesis; Carbohydrate Metabolism - pyruvate; EC 2.7.1.40; KINASE; Kinase, other; Mitochondrial; Nucleotide Metabolism - purine P52480 18746 9 B|9 32.03 cM mouse Y105-p 450528 FASDPILyRPVAVAL PK molecular association, regulation; intracellular localization; enzymatic activity, inhibited; phosphorylation carcinogenesis, induced; carcinogenesis, altered; cell differentiation, induced; apoptosis, induced; transcription, induced; signaling pathway regulation; cell growth, altered PKM iso2(DISRUPTS); PKM(INDUCES); PKM(DISRUPTS) 19920251; 23640882; 31988148; 32101747; 33984439; 35637461; 36244646; 36348389; 36450257; 37126714; 37196116 29 33 414 +APP APP iso4 Apoptosis; Cell surface; Membrane protein, integral; Receptor, misc.; Transcription factor P05067-4 351 21q21.3 human T668-p 448523 VEVDAAVtPEERHLS APP_amyloid protein stabilization; molecular association, regulation; protein processing; intracellular localization; phosphorylation apoptosis, altered; exocytosis, altered; transcription, induced; cytoskeletal reorganization; transcription, altered; cell growth, altered Fe65(DISRUPTS); TFCP2(INDUCES); APBA2(INDUCES); Fe65(INDUCES); PIN1(INDUCES); 14-3-3 gamma(DISRUPTS) 10341243; 11517218; 14970211; 15178331; 15944381; 16223726; 16554819; 16705182; 17085446; 17459339; 18833287; 21947912; 24610780 39 5 3 necessary for intraneuronal AB accumulation which leads to cell death (neurotoxicity); regulates Tau and GSK3B phosphorylation +SUV39H1 SUV39H1 Amino Acid Metabolism - lysine degradation; EC 2.1.1.43; METHYLTRANSFERASE; Methyltransferase; Methyltransferase, protein lysine O43463 6839 Xp11.23 human K105-m1 63128910 LRRHHRSkTPRHLDP enzymatic activity, inhibited chromatin organization, altered; cell growth, inhibited; transcription, induced 23509280 1 1 0 facilitated genomic instability +NR4A1 Nur77 Apoptosis; DNA-binding; Nuclear receptor P22736 3164 12q13.13 human S54-p 41583606 PTALPSFsTFMDGYT cell motility, induced; cell growth, induced; cytoskeletal reorganization 26155943 1 0 0 required for increase in cell growth, cell motility, monolayer permeability, and formation of actin stress fibers. +Cux1 CUTL1 DNA-binding; Membrane protein, integral; Transcription factor P53564 13047 5 G2|5 75.96 cM mouse S1155-p 457411 ILGLTQGsVSDLLAR CUT molecular association, regulation transcription, altered DNA(DISRUPTS) 9446557 1 0 0 +AURKA AurA EC 2.7.11.1; KINASE; Kinase, protein; Oncoprotein; Protein kinase, Other; Protein kinase, Ser/Thr (non-receptor) O14965 6790 20q13.2 human S284-p 2370900 WSVHAPSsRRTTLCG Pkinase enzymatic activity, induced 16785988 2 0 0 +ARHGAP35 GRF-1 GAP; GAP, Rac/Rho; Motility/polarity/chemotaxis; Transcription factor; Tumor suppressor Q9NRY4 2909 19q13.32 human T1173-p 3213723 GRFASYRtSFSVGSD RhoGAP_pG1_pG2 molecular association, regulation; activity, inhibited RND1(DISRUPTS) 19103606 1 3 0 +Bach2 BACH2 DNA-binding; Transcription factor P97303 12014 4|4 A5 mouse K579-sm 2798315 NQVRPQIkCEQSYGT intracellular localization transcription, inhibited 15060166 2 0 0 formation of PML bodies +BORA BORA Activator Q6PGQ7 79866 13q21.33 human S497-p 2512942 SSNIQMDsGYNTQNC protein degradation; molecular association, regulation cell cycle regulation BTRC(INDUCES) 18378770; 18521620; 34759346 3 0 0 +Ctnnd1 CTNND1 iso3 Actin-binding; Adaptor/scaffold; Cell adhesion; G protein regulator, misc.; Motility/polarity/chemotaxis P30999-3 12388 2 D|2 49.45 cM mouse Y280-p 450398 HRFHPEPyGLEDDQR cell cycle regulation; cell motility, altered 18515860 2 18 210 +Mnx1 MNX1 DNA-binding Q9QZW9 15285 5|5 B1 mouse S78-p 3191341 GDRLRAEsPSPPRLL molecular association, regulation; intracellular localization cell motility, altered; transcription, inhibited NONO(INDUCES) DNA(INDUCES) 24425879; 26342078 2 17 1 nuclear localization; nuclear localization, inhibits Cbl-b transcription +JUN Jun Oncoprotein; Transcription factor P05412 3725 1p32.1 human S243-p 450451 PGETPPLsPIDMESQ molecular association, regulation; ubiquitination; activity, inhibited; phosphorylation transcription, altered FBXW7(INDUCES); FBXW7(DISRUPTS); SP1(DISRUPTS) 1516134; 16023596; 17215518; 1846781; 21860413 13 25 18 +KRT18 K18 Cytoskeletal; Nucleolus P05783 3875 12q13.13 human K372-sm 25027603 ALLNIKVkLEAEIAT Filament cytoskeletal reorganization 21062750 1 1 0 sumoylation regulate solubility; modified by poly-SUMO-2/3 chains, oxidative stress, apoptosis, and/or phosphatase inhibition increase sumoylation in primary hepatocytes; K to R mutants show filament disorganization +CCDC6 CCDC6 Apoptosis; Cytoskeletal; Oncoprotein Q16204 8030 10q21.2 human K424-sm 27992505 SNSPDKFkRPTPPPS intracellular localization transcription, induced; signaling pathway regulation 23145146 1 0 0 cyclic AMP activity +Wasl N-WASP Adaptor/scaffold; Motility/polarity/chemotaxis O08816 682507 4q22 rat S480-p 3149548 KRSKAIHsSDEDEDD endocytosis, induced; cytoskeletal reorganization 21610097 4 19 2 Phosphorylation induces CK2-A1 and N-WASP complex formation and regulate cell surface EGFR levels by endocytosis. Phosphorylation reduces actin polymerization. +CARD11 CARD11 Adaptor/scaffold Q9BXL7 84433 7p22.2 human S615-p 5403700 RYSFGPSsIHSSSSS cell growth, inhibited; transcription, induced; transcription, inhibited; signaling pathway regulation 19118383; 26551667 3 0 0 NF-kB pathway, NF-kB transcription inhibited, lymphocyte proliferation decreased; Ser615Phe mutation increased NF-?B luciferase reporter activity +Cdk5 CDK5 Cell cycle regulation; EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, CMGC; Protein kinase, Ser/Thr (non-receptor) Q03114 140908 4q11 rat Y15-p 448022 EKIGEGTyGTVFKAK Pkinase apoptosis, inhibited; cell motility, altered 18701695; 35069828 17 47 894 +CDCA8 Borealin Cell cycle regulation; Nucleolus Q53HL2 55143 1p34.3 human T278-p 482837 QICSSIRtHK_____ cell growth, altered 17483322 1 0 0 +Prkcz PKCZ EC 2.7.11.13; KINASE; Kinase, protein; Protein kinase, AGC; Protein kinase, Ser/Thr (non-receptor) P09217 25522 5q36 rat T560-p 447572 TSEPVQLtPDDEDVI Pkinase_C protein degradation; phosphorylation; enzymatic activity, induced cytoskeletal reorganization desmin(DISRUPTS); TNNT1(DISRUPTS); TPM1(INDUCES); MYO1C(INDUCES); TNNI1(DISRUPTS) 11141077; 14580237; 17724026 13 8 0 +LIG1 LIG1 DNA repair, damage; EC 6.5.1.1; Ligase P18858 3978 19q13.33 human K226-ub 22246884 KPPRRAPkTLSSFFT protein degradation 27573245 1 2 0 +Thra TR-alpha DNA-binding; Nuclear receptor; Transcription factor P63058 21833 11 D|11 62.58 cM mouse K288-sm 38557703 AVKREQLkNGGLGVV Hormone_recep intracellular localization cell cycle regulation; cell growth, induced; transcription, induced DNA(INDUCES) 34916557 2 0 0 mutant mice had reduced fat stores on normal chow, and was reduced, more on high fat diets ; reduced CREB and AP1-mediated gene expression, reduced TR-alpha?CREB interaction in mutant preadipocytes; decreased preadipocyte proliferation, reduced white adipose stores and adipocyte cell diameter in mutant mice; (K283Q/K288R)-/- mutant: reduced nuclear localization of cyclin D1, cyclin D2, Cdk4 and Cdk2 in human primary preadipocytes +VAV1 VAV1 iso2 GEF; GEF, Rac/Rho; Motility/polarity/chemotaxis; Oncoprotein P15498-2 7409 19p13.3 human S748-p 12084454 ISRPAVGsTKYFGTA carcinogenesis, inhibited; signaling pathway regulation 30131370 0 3 1 +Nefm NFM Cytoskeletal P08553 18040 14|14 D1 mouse S610-p 448044 AKSPMPKsPVEEVKP cytoskeletal reorganization 19193875 3 29 24 slightly altered axoplasmic organization in 7S/A mice mutant +SPECC1L SPECC1L Cell cycle regulation Q69YQ0 23384 22q11.23 human S1003-p 23147747 EERKDPLsALAREYG cytoskeletal reorganization 36634848 1 2 1 +AKT1 Akt1 EC 2.7.11.1; KINASE; Kinase, protein; Oncoprotein; Protein kinase, AGC; Protein kinase, Ser/Thr (non-receptor) P31749 207 14q32.33 human Y474-p 447859 PHFPQFSySASGTA_ Pkinase_C enzymatic activity, induced 12149249 2 1 13 +ACLY ACLY Carbohydrate Metabolism - citrate (TCA) cycle; EC 2.3.3.8; Lyase; Transferase P53396 47 17q21.2 human K554-ub 59144801 EILIPVFkNMADAMR CoA_binding protein degradation carcinogenesis, inhibited; cell growth, inhibited 27664236 1 1 0 +CRYAB CRYAB Chaperone; Heat shock protein P02511 1410 11q23.1 human T170-gl 5281706 REEKPAVtAAPKK__ exocytosis, induced 26620801 4 4 0 +HABP4 HABP4 Transcription regulation Q5JVS0 22927 9q22.32 human K336-sm 1873147504 KYRDDMVkDDYEDDS IHABP4_N molecular association, regulation 28695742 1 0 0 Presence of SUMO-1 strongly influences the interaction of HABP4 (Ki-1/57) with other cellular proteins.; Fewer PML-nuclear bodies when compared to non-SUMOylated triple mutants, but not when treated with As2O2 +Rims1 RIMS1 Adaptor/scaffold; Vesicle Q9JIR4 84556 9q13 rat S413-p 450481 ARHERRHsDVALPHT activity, induced 14532002 4 6 0 Phosphorylation of RIM1alpha S413 is required for presynaptic LTP (long-term potentiation). +Tnnt2 TNNT2 iso2 Motility/polarity/chemotaxis; Motor P50753-2 24837 13q13 rat S199-p 451755 KAQTERKsGKRQTER Troponin protein conformation 24708997 9 0 0 T204E mutant blunts Ca2+ sensitivity, PKC phosphorylation of these residues can increase or decrease Ca2+ sensitivity and cardiac regulation +Rhoa RHOA G protein; G protein, monomeric; G protein, monomeric, Rho; Motility/polarity/chemotaxis; Oncoprotein Q9QUI0 11848 9|9 F1-F2 mouse S26-p 484601 TCLLIVFsKDQFPEV Ras activity, inhibited cytoskeletal reorganization; cell motility, inhibited 24872548 1 2 0 abnormal morphology-neuronal polarity and processes +Prkce PKCE EC 2.7.11.13; KINASE; Kinase, protein; Protein kinase, AGC; Protein kinase, Ser/Thr (non-receptor) P16054 18754 17|17 E4 mouse S368-p 2085101 NNIRKALsFDNRGEE molecular association, regulation 14-3-3 beta(INDUCES) 18237277 3 17 0 +Dnm1 DYN1 EC 3.6.5.5; Hydrolase; Microtubule-binding; Motility/polarity/chemotaxis; Motor; Vesicle P21575 140694 3p12 rat S857-p 455277 ASPSRPEsPRPPFDL molecular association, regulation; intracellular localization amphiphysin(DISRUPTS) 22857010 4 10 0 +DGCR8 DGCR8 Nucleolus; RNA processing; RNA-binding Q8WYQ5 54487 22q11.21 human T279-p 3208092 DHPSDGEtSVQPMMT protein stabilization 24239349 0 6 0 +RAP1B RAP1B G protein; G protein, monomeric; G protein, monomeric, Ras P61223 327708 cow S179-p 451799 PGKARKKsSCQLL__ intracellular localization; activity, inhibited cell motility, induced RASSF5(DISRUPTS) 23946483 8 1 0 1) Cytosolic relocalization of Rap1 is phosphorylation dependent. 2) Rap1 phosphorylation is necessary for cell migration. 3) Binding of Rap1 to RapL is decreased by PKA-dependent phosphorylation of S180. +Apbb2 ZFRA Q6DQH2 mouse S8-p 2868604 MSSRRSSsCKYCEQD PyrI_C molecular association, regulation; intracellular localization carcinogenesis, inhibited; apoptosis, induced ZFRA(INDUCES) 17567906; 18403180; 25686832 3 0 0 self-polymerization of wt Zfra blocks cancer growth in vivo; translocation of Zfra, WWOX, and p53 to mitochondria +XRCC5 Ku80 DNA-binding; EC 3.6.1.-; EC 3.6.4.-; Helicase; Nuclear receptor co-regulator; Nucleolus; RNA-binding P13010 7520 2q35 human K544-ub 12403528 FPLIEAKkKDQVTAQ Ku_C molecular association, regulation DNA repair, induced DNA(DISRUPTS) 27895153 1 0 3 +EPHA3 EphA3 EC 2.7.10.1; KINASE; Kinase, protein; Membrane protein, integral; Protein kinase, TK; Protein kinase, tyrosine (receptor) P29320 2042 3p11.1 human S768-p 7445291 KVSDFGLsRVLEDDP PK_Tyr_Ser-Thr protein conformation 18547520 1 3 0 +DCX Doublecortin iso2 Cytoskeletal; Motility/polarity/chemotaxis O43602-2 1641 Xq23 human S306-p 454122 GPMRRSKsPADSANG intracellular localization cell growth, inhibited; cytoskeletal reorganization 22359282 1 2 5 decreases process outgrowth in neurons +MAP3K1 MEKK1 EC 2.7.11.25; KINASE; Kinase, protein; Ligase; Protein kinase, STE; Protein kinase, Ser/Thr (non-receptor); UBIQUITIN LIGASE; Ubiquitin conjugating system; Ubiquitin ligase Q13233 4214 5q11.2 human S67-p 3053616 RQLRKVRsVELDQLP molecular association, regulation JNK1(DISRUPTS) 12228228 2 2 0 +EPS8 EPS8 Adaptor/scaffold Q12929 2059 12p12.3 human Y485-p 450732 EHSSVSEyHPADGYA cell cycle regulation; cell motility, induced 32641864 2 15 141 +MORC2 MORC2 DNA-binding Q9Y6X9 22880 22q12.2 human T556-gl 1879871300 TFRKDMKtQEEKQKQ transcription, induced 34974534 1 0 0 enhances promoter activities of SNAIL and CTGF +Kcnj5 GIRK4 Channel, potassium; Membrane protein, integral; Membrane protein, multi-pass P48545 16521 9 A4|9 17.65 cM mouse S418-p 1884003506 VSQATRGsM______ activity, induced; molecular association, regulation Other(INDUCES) 36584301 1 0 0 induces binding to PIP2 +Ppp2r5b PPP2R5B Motility/polarity/chemotaxis; Protein phosphatase, regulatory subunit Q6PD28 225849 19|19 A mouse S32-p 31895400 PDKVDGFsRRSLRRA molecular association, regulation; phosphorylation PPP2CA(INDUCES); PPP2R5B(INDUCES) 21329884 1 0 0 PPP2R2R5B phosphorylation by CLK2 is required for the PPP2CA-AKT complex; induces AKT dephosphorylation +FHOD1 FHOD1 Actin-binding Q9Y613 29109 16q22.1 human T1141-p 2035402 NRKSLRRtLKSGLGD activity, induced cell motility, induced; cell adhesion, induced; cytoskeletal reorganization; cell growth, altered FHOD1(DISRUPTS) 18239683; 21106951; 24331927 3 2 1 autoinhibitory interaction between C- and N-terminal part of FHOD1 is attenuated in S1130D/S1136D/T1140D triple mutant; induce actin polymerization +PAGE4 PAGE4 Cancer Testis Antigen (CTA) O60829 9506 Xp11.23 human S7-p 63280104 _MSARVRsRSRGRGD GAGE protein conformation 28289210 1 1 0 +Hspb6 HSP20 Chaperone; Heat shock protein Q5EBG6 243912 7|7 B1 mouse S10-p 36703149 IPVPVQPsWLRRASA Crystallin apoptosis, inhibited; transcription, inhibited 32218573 1 1 0 decreased ANP mRNA expression +Pde4a PDE4A EC 3.1.4.53; Nucleotide Metabolism - purine; Phosphodiesterase P54748 25638 8q13 rat S140-p 458389 TTSQRREsFLYRSDS protein conformation; enzymatic activity, induced 21323643 4 20 1 +PTPRA PTPRA EC 3.1.3.48; Membrane protein, integral; Motility/polarity/chemotaxis; PHOSPHATASE; Receptor protein phosphatase, tyrosine P18433 5786 20p13 human Y798-p 447613 YIDAFSDyANFK___ enzymatic activity, induced cytoskeletal reorganization 9439605 17 85 2339 Y798F mutant showed a different morphology compared to wild-type. +MRE11 MRE11A Cell cycle regulation; DNA repair, damage; DNA-binding; Deoxyribonuclease P49959 4361 11q21 human R572-m2 62978401 ATNKGRGrGRGRRGG DNA repair, altered 15741314 0 1 0 +SKAP1 SKAP55 Adaptor/scaffold; Motility/polarity/chemotaxis Q86WV1 8631 17q21.32 human Y271-p 455436 EKEEEDIyEVLPDEE molecular association, regulation GRB2(INDUCES); Fyn(INDUCES) 12171928 1 5 132 SKAP55-Y271F mutant abolished the enhancing effect of wild-type SKAP55 on MAPK activation after TCR cross-linking. +Havcr2 TIM-3 Membrane protein, integral; Receptor, misc. Q8VIM0 171285 11|11 B1.1 mouse Y256-p 470136 IRSEENIyTIEENVY molecular association, regulation BAT3(DISRUPTS) 22863785 5 0 0 +PRKCE PKCE EC 2.7.11.13; KINASE; Kinase, protein; Protein kinase, AGC; Protein kinase, Ser/Thr (non-receptor) Q02156 5581 2p21 human K321-ub 27852601 TNSGQRRkKLIAGAE molecular association, regulation carcinogenesis, induced; transcription, induced; signaling pathway regulation IKKG(INDUCES) 23123196 1 0 0 regulation of NF-kB and EGFR pathways in PKM2 upregulation and tumorigenesis +SPTA1 SPTA1 Cytoskeletal; Motility/polarity/chemotaxis P02549 6708 1q23.1 human Y422-p 13421405 HKHEIDSyDDRFQSA Spectrin cytoskeletal reorganization 20206558 1 1 0 +IRF3 IRF3 DNA-binding; Transcription factor Q14653 3661 19q13.33 human R285-m2 1881518207 GQWLWAQrLGHCHTY molecular association, regulation TIRAP(INDUCES); IRF3(INDUCES) 34583098 1 0 0 dimerization and enhanced its translocation to nucleus +Cdkn1a p21Cip1 Cell cycle regulation; Inhibitor P39689 12575 17 A3.3|17 15.12 cM mouse T140-p 447837 QGRKRRQtSLTDFYH protein stabilization; intracellular localization; activity, inhibited 21791608; 24848107 20 0 0 localized to cytoplasm +BUB1 BUB1 Cell cycle regulation; EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, Other; Protein kinase, Ser/Thr (non-receptor) O43683 699 2q13 human T589-p 3175277 WGIRCNKtLAPSPKS intracellular localization 26399325 1 3 0 T589 autophosphorylation limits H2A-pT120 and SGO1 to centromeres +NFE2L1 NFE2L1 DNA-binding; Transcription factor Q14494 4779 17q21.32 human S599-p 454236 PSALKKGsKEKQADF molecular association, regulation C/EBP-beta(INDUCES) 15308669 1 0 0 +Cgas cGAS EC 2.7.7.86 Q8C6L5 214763 9|9 E1 mouse K464-sm 59117702 LECLRTEkLDHYFIP Mab-21_C activity, induced; protein stabilization 27637147 1 0 0 regulates the stability of activated cGas +EPHB1 EphB1 EC 2.7.10.1; KINASE; Kinase, protein; Membrane protein, integral; Protein kinase, TK; Protein kinase, tyrosine (receptor) P54762 2047 3q22.2 human Y778-p 450471 DDTSDPTyTSSLGGK PK_Tyr_Ser-Thr molecular association, regulation SHC1(NOT_REPORTED); Src(NOT_REPORTED) 12925710 2 4 16 +FBXO31 FBXO31 Cell cycle regulation; UBIQUITIN LIGASE; Ubiquitin conjugating system; Ubiquitin ligase Q5XUX0 79791 16q24.2 human K330-ub 573772184 GRRARGTkITGDPNI Cyclin_D1_bind protein degradation; molecular association, regulation; ubiquitination; enzymatic activity, induced CCND1(INDUCES); CCND3(INDUCES); CCND2(INDUCES) 29279382 1 1 0 promotes cyclinD1 degradation not affected by ERK2-mediated phosphorylation +Tcap Telethonin Motility/polarity/chemotaxis O70548 21393 11|11 D mouse S157-p 448693 GPLRRTLsRSMSQEA Telethonin protein stabilization; ubiquitination 34566695 4 5 3 inhibits ubiquitination +BAIAP2L1 IRTKS Adaptor/scaffold; Cytoskeletal Q9UHR4 55971 7q21.3-q22.1 human Y156-p 462515 GSRNALKyEHKEIEY IMD cell motility, induced 21840312 1 2 31 +CTNNB1 CTNNB1 Actin-binding; Cell adhesion; Motility/polarity/chemotaxis; Nuclear receptor co-regulator; Oncoprotein; Transcription factor P35222 1499 3p22.1 human T112-p 3075001 EGMQIPStQFDAAHP protein degradation; intracellular localization cell growth, inhibited; cell motility, altered; transcription, induced; cell motility, inhibited CTNNA1(INDUCES) 12432063; 19141652 3 0 0 +L1CAM NCAM-L1 Cell adhesion; Membrane protein, integral P32004 3897 Xq28 human T1247-p 485892 GNDSSGAtSPINPAV molecular association, regulation 21080252 1 6 0 mutation of T1247 and S1248, alone or together had little effect on C20 binding +NFE2L2 NRF2 DNA-binding; Transcription factor Q16236 4780 2q31.2 human T369-p 1876350200 ESSSYGDtLLGLSDS protein degradation; ubiquitination; intracellular localization apoptosis, induced; transcription, inhibited 35108418 1 0 0 +PPP1R3F PPP1R3F Membrane protein, integral; Protein phosphatase, regulatory subunit Q6ZSY5 89801 Xp11.23 human S420-p 22650300 PAIRIPPsSPLCGLG signaling pathway regulation 21668450 0 1 0 regulation of glycogen synthesis via R3F-PP1 signaling in astrocytoma cells +FBP1 FBPase Carbohydrate Metabolism - fructose and mannose; Carbohydrate Metabolism - glycolysis and gluconeogenesis; Carbohydrate Metabolism - pentose phosphate pathway; EC 3.1.3.11; Mitochondrial; Phosphatase (non-protein) P09467 2203 9q22.32 human S170-p 1880113501 AGYALYGsATMLVLA molecular association, regulation; intracellular localization carcinogenesis, inhibited; apoptosis, induced; transcription, altered H3(INDUCES); PPAR-alpha(INDUCES); KPNA4(INDUCES); FBPase(DISRUPTS) 36266488 2 1 0 dephosphorylates H3 +Krt8 K8 Cytoskeletal P11679 16691 15 F2|15 57.2 cM mouse S80-p 448539 TVNQSLLsPLKLEVD Keratin_2_head molecular association, regulation; intracellular localization carcinogenesis, induced; apoptosis, inhibited; cytoskeletal reorganization 10623656; 16563375; 16818723; 33847415 29 8 9 +Smo SMO Cell development/differentiation; GPCR, Fz/Smo family; Membrane protein, integral; Membrane protein, multi-pass; Oncoprotein; Receptor, GPCR P56726 319757 6 A3.3|6 12.36 cM mouse S642-p 1872776120 AILPQDVsVTPVATP molecular association, regulation transcription, induced PKACA(INDUCES) 33886552 1 1 0 +PRKAR1A PKAR1A Protein kinase, regulatory subunit P10644 5573 17q24.2 human S83-p 450936 DSREDEIsPPPPNPV molecular association, regulation; enzymatic activity, inhibited cell cycle regulation; carcinogenesis, induced PKACA(INDUCES); RFC2(DISRUPTS); MYO10(INDUCES) 16582606; 23942052; 25605337; 35977512; 36114575 5 111 240 +MASTL MASTL EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, AGC; Protein kinase, Ser/Thr (non-receptor) Q96GX5 84930 10p12.1 human T860-p 58984001 QPDDETDtSYFEARN protein conformation 21444715 1 1 0 +Csf1r CSFR EC 2.7.10.1; KINASE; Kinase, protein; Membrane protein, integral; Oncoprotein; Protein kinase, TK; Protein kinase, tyrosine (receptor) P09581 12978 18 E1|18 34.41 cM mouse Y721-p 448364 SSQGVDTyVEMRPVS PK_Tyr_Ser-Thr molecular association, regulation; enzymatic activity, induced; phosphorylation carcinogenesis, induced; cell motility, induced; cell adhesion, induced; signaling pathway regulation; cell differentiation, altered; cell motility, altered; cytoskeletal reorganization; transcription, inhibited; cell growth, altered PLCG1(INDUCES); SOCS1(INDUCES); PIK3R1(INDUCES) 11297560; 17420256; 18519746; 21610095; 23648053; 7545432; 8262059; 9312046 15 0 1 +Cbx3 CBX3 DNA-binding Q5RJK5 297093 4q24 rat S93-p 457001 KDGTKRKsLSDSESD protein degradation; intracellular localization cell differentiation, induced; transcription, induced 30305677 5 57 61 regulation of expression of distinct gene subset +IRF3 IRF3 DNA-binding; Transcription factor Q14653 3661 19q13.33 human S386-p 448684 ARVGGASsLENTVDL activity, induced; molecular association, regulation; intracellular localization; protein conformation; enzymatic activity, induced; phosphorylation apoptosis, inhibited; transcription, induced; transcription, altered IRF3(INDUCES); p300(INDUCES); CBP(INDUCES) 10920266; 14703513; 17526488; 18272581; 18440553; 20511230; 20604809; 31882361; 34799452; 35879450; 35948267; 9463386 26 8 0 +Gja1 GJA1 Channel, misc.; Membrane protein, integral; Membrane protein, multi-pass; Motility/polarity/chemotaxis P08050 24392 20q11 rat Y313-p 454254 SEQNWANySAEQNRM Connexin43 molecular association, regulation cytoskeletal reorganization CTNNB1(DISRUPTS) 29882937; 32956670 5 20 298 regulation of gap junction intercellular communication +DES desmin Cytoskeletal; Motility/polarity/chemotaxis P17661 1674 2q35 human T17-p 449613 RVSSYRRtFGGAPGF Filament_head cytoskeletal reorganization 12686604 1 3 1 Mutated desmin sites showed failure of desmin filaments to segregate into daughter cells. +ATM ATM DNA repair, damage; EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, Ser/Thr (non-receptor); Protein kinase, atypical; Tumor suppressor Q13315 472 11q22.3 human T86-p 481862 KPNVSAStQASRQKK TAN molecular association, regulation; enzymatic activity, inhibited; protein conformation cell cycle regulation; apoptosis, inhibited MRE11A(DISRUPTS); NBS1(DISRUPTS) 27939942 1 1 0 +Eif2ak1 HRI EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, Other; Protein kinase, Ser/Thr (non-receptor); Translation Q9Z2R9 15467 5|5 G2 mouse T485-p 447595 GKGTRTHtSRVGTCL Pkinase phosphorylation; enzymatic activity, induced 12767237 1 1 0 +EIF4ENIF1 4E-T Karyopherin; Nuclear import; Translation Q9NRA8 56478 22q12.2 human S301-p 14572931 DAVLPEQsPGDFDFN EIF4E-T molecular association, regulation 4E-T(INDUCES) 22966201 1 13 7 required for processing bodies (PBs or P bodies) assembly +Igf2bp1 IGF2BP1 RNA-binding; Translation O88477 140486 11 D|11 59.08 cM mouse S181-p 453893 RGQPRQGsPVAAGAP molecular association, regulation RNA splicing, induced; cell growth, induced; translation, induced RNA(INDUCES) 23388827 3 59 12 +KCNQ1 Kv7.1 Channel, potassium; Membrane protein, integral; Membrane protein, multi-pass P51787 3784 11p15.5-p15.4 human S468-p 2999201 YDSSVRKsPTLLEVS activity, induced 12835205 1 1 0 +Septin5 SEPT5 Cell cycle regulation; Cytoskeletal; Hydrolase; Vesicle Q9JJM9 116728 11q23 rat S327-p 454379 TQDSRMEsPIPILPL molecular association, regulation exocytosis, altered STX1A(DISRUPTS) 18385322 2 27 2 +Csk CSK EC 2.7.10.2; KINASE; Kinase, protein; Protein kinase, TK; Protein kinase, tyrosine (non-receptor) P41241 12988 9 B|9 31.18 cM mouse S284-p 23096469 YLRSRGRsVLGGDCL PK_Tyr_Ser-Thr phosphorylation; enzymatic activity, induced signaling pathway regulation 31011187 1 1 2 induces phosphorylation of Lyn, regulates BCR signaling +Neurog1 neurogenin 1 Cell development/differentiation; DNA-binding; Transcription factor P70595 29410 17p14 rat S179-p 7590801 PCLPGPPsPASDTES transcription, induced; cell growth, altered 19365559 1 0 0 +Cadps CADPS Vesicle Q62717 26989 15p15 rat S5-p 7712502 ___MLDPsSSEEESD activity, induced exocytosis, altered 19460754 1 2 0 +CENPA CENPA DNA-binding P49450 1058 2p23.3 human S68-p 38520200 LIRKLPFsRLAREIC Histone protein degradation; intracellular localization cell cycle regulation 34758320 4 2 0 Ser68 facilitates degradation +HNRNPUL1 E1B-AP5 RNA splicing; RNA-binding Q9BUJ2 11100 19q13.2 human R612-me 41259008 PEKRFDNrGGGGFRG molecular association, regulation; intracellular localization NBS1(INDUCES) 26020839 1 1 0 ecruitment at sites of damage +BUB1B BUB1B EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, Other; Protein kinase, Ser/Thr (non-receptor); Tumor suppressor O60566 701 15q15.1 human T620-p 767908 RAARFVStPFHEIMS protein stabilization; molecular association, regulation; phosphorylation cell cycle regulation; cytoskeletal reorganization; signaling pathway regulation PLK1(INDUCES) 17785528; 33125045 3 0 0 induces KNL1-MELT signaling; in vitro and in vivo association with PLK1 +HIF1A HIF1A Autophagy; DNA-binding; Transcription factor Q16665 3091 14q23.2 human K391-sm 2793906 SSLFDKLkKEPDALT protein stabilization transcription, induced; transcription, inhibited 15465032; 19680224 2 1 0 +Zc3hc1 NIPA Cell cycle regulation; Ubiquitin conjugating system Q80YV2 232679 6|6 A3.3 mouse S353-p 449745 PIVSRTRsWESSSPV molecular association, regulation cell cycle regulation CUL1(DISRUPTS) 22955283 4 41 32 ERK2 phosphorylation at G2/M is sufficient dissociation of SCF core complex at G2/M. +PARP1 PARP1 DNA repair, damage; EC 2.4.2.30; Nuclear envelope; Nuclear receptor co-regulator; Nucleolus; Transferase P09874 142 1q42.12 human Y992-p 1875398902 LYNEYIVyDIAQVNL PARP cell cycle regulation; carcinogenesis, induced; cell growth, induced; apoptosis, inhibited 34762994 1 0 0 +Grin1 NMDAR1 Channel, calcium; Channel, ligand-gated; Membrane protein, integral; Membrane protein, multi-pass P35439 24408 3p13 rat S889-p 449107 AITSTLAsSFKRRRS molecular association, regulation Calmodulin(DISRUPTS) 9252405 4 0 1 +SLC6A4 SERT Membrane protein, integral; Membrane protein, multi-pass; Transporter P31645 6532 17q11.2 human T613-p 7576401 ERIIKSItPETPTEI molecular association, regulation; intracellular localization Vimentin(DISRUPTS) 19270731 1 0 1 +Traf2 TRAF2 Autophagy; EC 6.3.2.-; Ligase; UBIQUITIN LIGASE; Ubiquitin conjugating system; Ubiquitin ligase P39429 22030 2|2 A3 mouse S11-p 5397201 ASVTSPGsLELLQPG cell differentiation, altered 34910106 6 15 0 +TP53RK PRPK EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, Other; Protein kinase, Ser/Thr (non-receptor) Q96S44 112858 20q13.12 human S250-p 1981300 RLRGRKRsMVG____ enzymatic activity, induced carcinogenesis, induced; cell motility, induced; signaling pathway regulation 17712528; 28412249; 29904102 3 0 7 PBK/PRPK pathway; promoting metastasis +GUCA1B GCAP2 Calcium-binding P51177 286851 cow S201-p 455322 ISQQRRKsAMF____ molecular association, regulation; intracellular localization 14-3-3 epsilon(INDUCES) 25058152 3 0 0 proximal rod compartments +TAB1 TAB1 Activator; Motility/polarity/chemotaxis Q15750 10454 22q13.1 human K294-ub 1881312003 LMSEGLYkALEAAHG signaling pathway regulation 34017102 1 0 0 TRIM26 enhances TLRs-induced NF-kB and MAPK signaling. +USP2 USP2 DEUBIQUITINASE; EC 3.4.19.12; Protease; Ubiquitin-specific protease O75604 9099 11q23.3 human S207-p 803501400 ENYGRKGsASQVPSQ molecular association, regulation 29490279 1 1 0 disassociation of phosphorylated R-SMADs from the receptor complex; USP2a promotes TGF-beta-induced EMT and metastasis +PRKDC DNAPK DNA repair, damage; EC 2.7.11.1; KINASE; Kinase, protein; Nucleolus; Protein kinase, Ser/Thr (non-receptor); Protein kinase, atypical P78527 5591 8q11.21 human S2672-p 3193631 DPLVDHTsPSSDSLL DNAPKcs_CC5 DNA repair, inhibited 24687855 1 3 0 cell survival inhibited +CXCR4 CXCR4 GPCR, family 1; Membrane protein, integral; Membrane protein, multi-pass; Receptor, GPCR P61073 7852 2q22.1 human S324-p 6140803 LTSVSRGsSLKILSK receptor desensitization, induced; receptor internalization, induced; protein degradation; molecular association, regulation; enzymatic activity, induced; activity, induced; ubiquitination; intracellular localization endocytosis, induced ITCH(INDUCES) 19116316; 25355818; 30327409; 30936203; 34973340 12 11 4 +Kdr VEGFR2 EC 2.7.10.1; KINASE; Kinase, protein; Membrane protein, integral; Protein kinase, TK; Protein kinase, tyrosine (receptor) P35918 16542 5 C3.3|5 40.23 cM mouse Y949-p 447903 RFRQGKDyVGELSVD PK_Tyr_Ser-Thr molecular association, regulation; intracellular localization carcinogenesis, inhibited; cell growth, inhibited; cell motility, altered; cytoskeletal reorganization Src(DISRUPTS); TSAd(INDUCES); CDH5(DISRUPTS) 15962004; 33726754 20 0 3 regulates VE-Cadherin localization +CC2D1A CC2D1A Transcription factor Q6P1N0 54862 19p13.12 human S208-p 483763 PASTPTYsPAPTQPA molecular association, regulation cell cycle regulation RAD21(INDUCES) 20171170 2 15 21 +POLH POLH DNA repair, damage; EC 2.7.7.7; Transferase Q9Y253 5429 6p21.1 human K163-sm 62518201 TAEETVQkEGMRKQG IMS enzymatic activity, inhibited; intracellular localization 27811911; 32350109 2 1 0 +PDCD4 PDCD4 Apoptosis; Tumor suppressor Q53EL6 27250 10q25.2 human S67-p 458381 KRRLRKNsSRDSGRG protein degradation; molecular association, regulation cell cycle regulation; translation, altered; cell growth, altered BTRC(INDUCES) 17053147 5 9 44 +Neurod1 NEUROD1 DNA-binding; Transcription factor Q64289 29458 3q24 rat S274-p 465680 PSFDGPLsPPLSING Neuro_bHLH intracellular localization 12297313; 25752781 3 0 0 +TFEB TFEB DNA-binding; Transcription factor P19484 7942 6p21.1 human S122-p 3181616 PKPPPAAsPGVRAGH MITF_TFEB_C_3_N activity, induced; intracellular localization transcription, inhibited; cell growth, altered 28055300; 29945972 5 37 0 +TP53 p53 Activator; DNA-binding; Motility/polarity/chemotaxis; Nuclear receptor co-regulator; Transcription factor; Tumor suppressor P04637 7157 17p13.1 human K101-ub 486292 SSSVPSQkTYQGSYG P53 protein degradation; intracellular localization 17371868; 31492752 2 3 0 +TRIM21 TRIM21 EC 6.3.2.-; Ligase; UBIQUITIN LIGASE; Ubiquitin conjugating system; Ubiquitin ligase P19474 6737 11p15.4 human Y393-p 25120401 QKYEAGTyPQTPLHL SPRY activity, induced; molecular association, regulation IRF3(INDUCES) 22479513 1 0 0 +Trhr TRHR GPCR, family 1; Membrane protein, integral; Membrane protein, multi-pass; Receptor, GPCR Q01717 25570 7q31 rat S383-p 465594 YVSTTKVsFDDTCLA receptor internalization, altered 11278484 1 0 0 S383, T365, T371 are important for the receptor internalization +ELF4 ELF4 DNA-binding; Oncoprotein; Transcription factor Q99607 2000 Xq26.1 human K657-sm 3470700 FNPTSLIkMEPHDI_ molecular association, regulation transcription, inhibited DNA(DISRUPTS) 16904644 1 1 0 +SAV1 SAV1 Adaptor/scaffold Q9H4B6 60485 14q22.1 human S36-p 21507300 LLRNLMPsFIRHGPT protein conformation apoptosis, induced 21944251 1 3 1 self-dimerization; increase in protein level +Cebpa C/EBP-alpha DNA-binding; Transcription factor P05554 24252 1q21 rat S21-p 448308 PMSSHLQsPPHAPSN molecular association, regulation cell cycle regulation; cell growth, inhibited; cell differentiation, induced; transcription, inhibited E2F3(INDUCES); E2F2(INDUCES) 22212957 10 1 0 E2F-dependent transactivation +EIF2AK2 PKR EC 2.7.10.2; EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, Other; Protein kinase, Ser/Thr (non-receptor); Protein kinase, tyrosine (non-receptor); Translation P19525 5610 2p22.2 human S83-p 3181640 NKEKKAVsPLLLTTT enzymatic activity, induced carcinogenesis, induced; cell motility, induced; cell growth, induced; apoptosis, inhibited 11152499; 34799660 2 12 3 +ITGA4 ITGA4 Cell adhesion; Membrane protein, integral; Motility/polarity/chemotaxis; Receptor, misc. P13612 3676 2q31.3 human Y1024-p 7705802 NRRDSWSyINSKSND molecular association, regulation cytoskeletal reorganization; cell motility, inhibited PXN iso2(INDUCES); PXN(INDUCES) 19401330; 23979717 3 2 5 rescued by Rac1 inhibition +MTHFD1 MTHFD1 Carbohydrate Metabolism - glyoxylate and dicarboxylate; Cofactor and Vitamin Metabolism - one carbon pool by folate; EC 1.5.1.5; EC 3.5.4.9; EC 6.3.4.3; Hydrolase; Ligase; Mitochondrial; Oxidoreductase P11586 4522 14q23.3 human K223-sm 63343000 TGQPEMVkGEWIKPG THF_DHG_CYH_C protein degradation; ubiquitination; intracellular localization 28265077 1 0 0 +CASP6 CASP6 Apoptosis; EC 3.4.22.59; Protease P55212 839 4q25 human C264-pa 60885600 SQRRVDFcKDPSAIG Peptidase_C14 molecular association, regulation; enzymatic activity, inhibited; protein conformation 27911442 1 0 0 Palmitoylation inhibits CASP6 activity by blocking substrate binding site and dimerization. +Clip1 Restin Cytoskeletal Q9JK25 65201 12q16 rat S319-p 2509335 ASSLSSMsSVASSVS molecular association, regulation; protein conformation TUBA1C(DISRUPTS) 20519438 1 2 0 +PELP1 PELP1 Nuclear receptor co-regulator; Transcription, coactivator/corepressor Q8IZL8 27043 17p13.2 human K826-sm 1872504900 ASPPVPAkEEPEELP intracellular localization 21326211 1 0 0 regulates nucleolar partioning of ribosome biogenesis complex and determines the rate of ribosome formation +CSF2RB CSF2RB Membrane protein, integral; Receptor, cytokine P32927 1439 22q12.3 human Y882-p 2358800 KALKQQDyLSLPPWE activity, induced transcription, altered; cell growth, altered 10329850 2 0 0 +Cacnb1 CACNB1 Channel, calcium P54283 50688 10q31 rat S348-p 459046 IVYIKITsPKVLQRL Guanylate_kin activity, induced 16406008 1 0 0 +IREB2 IREB2 RNA-binding; Translation P48200 3658 15q25.1 human S157-p 2850010 LQKAGKLsPLKVQPK molecular association, regulation translation, altered RNA(DISRUPTS) 18574241 1 12 0 regulates the iron-independent synthesis of ferritin +YWHAB 14-3-3 beta Adaptor/scaffold P31946 7529 20q13.12 human K122-ac 3649439 ESKVFYLkMKGDYFR 14-3-3 molecular association, regulation SYNPO(DISRUPTS) 23840712 1 5 10 +FZR1 FZR1 UBIQUITIN LIGASE; Ubiquitin conjugating system Q9UM11 51343 19p13.3 human S39-gl 55596601 TPASSPVsSPSKHGD activity, induced; molecular association, regulation CDC27(INDUCES) 27080259 1 1 0 promotes the interaction between FZR1 and APC/C subunits, enhances APC/C activity +PLK1 PLK1 EC 2.7.11.21; KINASE; Kinase, protein; Protein kinase, Other; Protein kinase, Ser/Thr (non-receptor) P53350 5347 16p12.2 human T214-p 3191824 RKKTLCGtPNYIAPE Pkinase enzymatic activity, induced cell cycle regulation; cell growth, induced 26919439 1 14 9 crucial residue for Plk1 function in mitosis +NOS3 eNOS Amino Acid Metabolism - arginine and proline; EC 1.14.13.39; Oxidoreductase Q7YSG7 397557 pig S1179-p 447884 TSRIRTQsFSLQERH enzymatic activity, induced 15333638 217 18 7 +FOXC1 FOXC1 Cell cycle regulation; Cell development/differentiation; DNA-binding; Transcription factor Q12948 2296 6p25.3 human S241-p 3195017 PSPPQPLsPAAALGS protein stabilization; molecular association, regulation carcinogenesis, induced; cell motility, induced; transcription, induced DNA(INDUCES) 31650548 1 21 1 ubiquitination and protein degradation inhibited. increased MMP10, SOX4 and SOX13 expression levels +DSN1 DSN1 Cell cycle regulation Q9H410 79980 20q11.23 human S109-p 3595501 KETNRRKsLHPIHQG MIS13 molecular association, regulation; intracellular localization cell cycle regulation MIS12(INDUCES); CENPC1(INDUCES) 18640974; 25601404; 27881301; 32027339; 34758321 8 17 4 +Slc28a2 SLC28A2 Membrane protein, integral; Membrane protein, multi-pass; Transporter; Transporter, SLC family Q62773 60423 3q35 rat S46-p 4700175 EEVTQGHsLKDGLGH intracellular localization 22136384 1 3 0 +CDKN1A p21Cip1 Cell cycle regulation; Inhibitor P38936 1026 6p21.2 human S114-p 478191 EEDHVDLsLSCTLVP protein degradation 17283049 1 0 0 ubiquitination-independent degradation +PRMT5 PRMT5 Cell cycle regulation; EC 2.1.1.125; METHYLTRANSFERASE; Methyltransferase; Methyltransferase, protein arginine; RNA processing O14744 10419 14q11.2 human Y307-p 18545700 FAKGYEDyLQSPLQP PRMT5 molecular association, regulation; enzymatic activity, inhibited carcinogenesis, altered; cell growth, altered PRMT5(DISRUPTS) 21316606 1 0 0 contributes to the mutant Jak2 V617F -induced myeloproliferative phenotype; negatively regulates hematopoietic stem/progenitor cell expansion and erythroid differentiation +Sirpa SHPS1 Cell adhesion; Cell surface; Membrane protein, integral; Motility/polarity/chemotaxis; Receptor, misc. P97710 25528 3q36 rat Y501-p 451115 PEPSFSEyASVQVQR molecular association, regulation SHP-2(INDUCES) 9535915 5 16 136 +LAT2 LAB Adaptor/scaffold; Membrane protein, integral Q9GZY6 7462 7q11.23 human Y233-p 450646 EEDGEPDyVNGEVAA LAT2 molecular association, regulation cell differentiation, altered GRB2(INDUCES); PLCG1(INDUCES) 14722116; 17993265 3 1 6 +ERBB4 HER4 EC 2.7.10.1; KINASE; Kinase, protein; Membrane protein, integral; Protein kinase, TK; Protein kinase, tyrosine (receptor) Q15303 2066 2q34 human Y875-p 2045333 LEGDEKEyNADGGKM PK_Tyr_Ser-Thr molecular association, regulation PLCG2(INDUCES) 18721752 0 1 6 +ENSA ENSA Inhibitor; Protein phosphatase, regulatory subunit O43768 2029 1q21.3 human S109-p 477819 DLPQRKSsLVTSKLA Endosulfine molecular association, regulation; protein conformation SNCA(DISRUPTS) 18973346 2 39 50 membrane binding +RFX1 RFX1 DNA-binding P22670 5989 19p13.12 human T124-p 31871835 SEASPGStASQTGVP transcription, inhibited 26041775 1 1 0 +Vcl Vinculin Cell adhesion; Cytoskeletal; Motility/polarity/chemotaxis Q64727 22330 14 A3|14 11.53 cM mouse S1033-p 451251 NAQNLMQsVKETVRE Vinculin cell adhesion, induced; cytoskeletal reorganization 24996180 2 0 0 stiffness and strain energy, activation of vinculin and force transmission in focal adhesions +DNMT1 DNMT1 Amino Acid Metabolism - cysteine and methionine; Cell development/differentiation; EC 2.1.1.37; METHYLTRANSFERASE; Methyltransferase; Methyltransferase, DNA; Transcription regulation P26358 1786 19p13.2 human K188-ac 25171004 QEESERAkSDESIKE cell cycle regulation 21947282 1 1 0 +PRDX3 PRDX3 Apoptosis; EC 1.11.1.15; Mitochondrial; Oxidoreductase P30048 10935 10q26.11 human K253-ac 36292413 ASKEYFQkVNQ____ 1-cysPrx_C apoptosis, induced PRDX3(DISRUPTS) 31655428 1 1 0 inhibits dimerization, H2O2 induced the dimerization +Stk17b DRAK2 EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, CAMK; Protein kinase, Ser/Thr (non-receptor) Q8BG48 98267 1|1 C1.1 mouse S12-p 1851300 RFDCRSVsGLLTTTP activity, induced 17182616 2 4 0 Ca(2+) mobilization +Opn4 melanopsin GPCR, family 1; Membrane protein, integral; Membrane protein, multi-pass; Receptor, GPCR Q9QXZ9 30044 14|14 B mouse S391-p 1868515100 STHRSTLsSQSSDLS molecular association, regulation; protein conformation ARRB1(INDUCES) 32236094 1 1 0 +Cux1 CUTL1 DNA-binding; Membrane protein, integral; Transcription factor P53564 13047 5 G2|5 75.96 cM mouse S583-p 457409 VLGLSQGsVSEILAR CUT molecular association, regulation transcription, altered DNA(DISRUPTS) 9446557 1 0 1 +Pdpk1 PDK1 EC 2.7.11.1; KINASE; Kinase, protein; Nuclear receptor co-regulator; Protein kinase, AGC; Protein kinase, Ser/Thr (non-receptor) O55173 81745 10q12 rat Y9-p 447696 ARTTSQLyDAVPIQS enzymatic activity, induced translation, altered; cell adhesion, altered 18559349 5 1 6 Induces fibronectin expression and deposition and increases AngII mesangial cell hypertrophy +Mtor mTOR Autophagy; EC 2.7.11.1; KINASE; Kinase, protein; Motility/polarity/chemotaxis; Protein kinase, Ser/Thr (non-receptor); Protein kinase, atypical Q9JLN9 56717 4 E2|4 78.76 cM mouse S2481-p 447498 TVPESIHsFIGDGLV acetylation; intracellular localization; phosphorylation; enzymatic activity, induced 20022946; 33547375 69 29 1 decreases acetylation of HSP90 by increasing HDAC6 expression, thereby affecting Cx43 localization; induces HDAC6 phosphorylation +CDKN2A p14ARF SUMO LIGASE; SUMO conjugating system Q8N726 1029 9p21.3 human T8-p 27523604 MVRRFLVtLRIRRAC P19Arf_N protein stabilization; intracellular localization cell growth, induced; cell adhesion, altered 23308265; 25723571; 29728595 3 0 0 ARF accumulation in the cytoplasm; mediate both cell spreading and FAK activation; T8-p induces accumulation of the protein both in the cytoplasm and in the nucleus. Cytoplasmic localized ARF is phosphorylated.; T8D mutant localized in cytoplasm +Pparg PPAR-gamma DNA-binding; Nuclear receptor; Transcription factor P37238 19016 6 E3|6 53.41 cM mouse K293-ub 1877844703 GEDKIKFkHITPLQE protein degradation; ubiquitination cell differentiation, inhibited 31653699 1 1 0 +TOPORS TOPORS Cell cycle regulation; EC 6.3.2.-; EC 6.3.2.19; Ligase; SUMO LIGASE; SUMO conjugating system; SUMO ligase; UBIQUITIN LIGASE; Ubiquitin conjugating system; Ubiquitin ligase Q9NS56 10210 9p21.1 human S98-p 453973 QTVPADAsPDSKCPI protein degradation; molecular association, regulation; ubiquitination; enzymatic activity, altered; enzymatic activity, induced UBE2D1(INDUCES) 19053840; 26872363 2 49 1 regulation of E3 ligase activities of TOPORS; regulates the ubiquitin, but not the SUMO ligase activity of TOPORS +AURKB AurB EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, Other; Protein kinase, Ser/Thr (non-receptor) Q96GD4 9212 17p13.1 human S331-p 22259700 HPWVRANsRRVLPPS molecular association, regulation; intracellular localization; enzymatic activity, induced cell cycle regulation; chromatin organization, altered; cytoskeletal reorganization Survivin(INDUCES) 22024163; 24344188; 24798733; 33355621 5 0 0 +Etv1 ETV1 DNA-binding; Oncoprotein; Transcription factor P41164 14009 12 A3|12 17.99 cM mouse S191-p 3059602 HRFRRQLsEPCNSFP ETS_PEA3_N activity, inhibited transcription, altered 10982847 3 0 3 in Mv1Lu cells (mutation shows no effect in HeLa cells) +MSN Moesin Cytoskeletal; Motility/polarity/chemotaxis P26038 4478 Xq12 human T66-p 18911798 LKLNKKVtAQDVRKE FERM_N intracellular localization carcinogenesis, induced; cell motility, induced; cell growth, induced; cell adhesion, inhibited 24755472 1 2 0 cell spreading inhibited, moesin distribution regulation, increased cell migration and cell invasion and metastasis +Zdhhc5 ZDHHC5 EC 2.3.1.225; Membrane protein, integral; Membrane protein, multi-pass; Transferase Q8VDZ4 228136 2|2 D mouse Y91-p 462809 DDFRAPLyKTVEIKG receptor internalization, induced; enzymatic activity, inhibited; phosphorylation; palmitoylation endocytosis, induced 32958780 1 5 88 inhibits palmitoylation of CD36 further inducing phosphorylation of SYK and then VAV and JNK +CAMK4 CAMK4 EC 2.7.11.17; KINASE; Kinase, protein; Protein kinase, CAMK; Protein kinase, Ser/Thr (non-receptor) Q16566 814 5q22.1 human S58-gl 7780003 ELGRGATsIVYRCKQ Pkinase phosphorylation 19506079 1 1 0 reduce phosphorylation at CAMK4-T200 +NUP98 NUP98 iso2 Motility/polarity/chemotaxis; Nucleoporin P52948-2 4928 11p15.4 human S636-p 4740143 QQDGDEDsLVSHFYT intracellular localization 21335236 1 18 2 as multiple sites (13PM) mutant +Pdgfrb PDGFRB EC 2.7.10.1; KINASE; Kinase, protein; Membrane protein, integral; Oncoprotein; Protein kinase, TK; Protein kinase, tyrosine (receptor) P05622 18596 18 E1|18 34.41 cM mouse Y1020-p 447523 PNESDNDyIIPLPDP phosphorylation 11940581 21 0 0 tyrosine phosphorylation of Gab1 +RPA2 RFA2 DNA replication P15927 6118 1p35.3 human S29-p 448338 QSPGGFGsPAPSQAE molecular association, regulation; intracellular localization cell cycle regulation; DNA repair, induced; transcription, altered p53(INDUCES); WRN(INDUCES) 17928296; 19671522; 20154705; 21107010; 21664290; 26237679; 29875999 11 5 0 +DUSP1 DUSP1 EC 3.1.3.16; EC 3.1.3.48; Motility/polarity/chemotaxis; PHOSPHATASE; Protein phosphatase, dual-specificity P28562 1843 5q35.1 human S334-p 53736000 AVLDRGTsTTTVFNF protein degradation; ubiquitination; phosphorylation signaling pathway regulation 25799226 1 0 0 induces phosphorylation of IRS-1 subsequently inhibiting phosphorylation of AKT, regulates P38-Jnk pathway +THRA TR-alpha DNA-binding; Nuclear receptor; Transcription factor NP_990644 396251 chicken K128-ac 10769107 DLVLDDSkRVAKRKL molecular association, regulation carcinogenesis, inhibited; transcription, altered SMRT(DISRUPTS); ACTR1A(INDUCES) DNA(INDUCES) 19819978 1 0 0 induces transactivation and transrepression of transcription +Tnp2 TP2 DNA-binding P11101 24840 10q11 rat K105-ac 10769112 RKRTHRAkRRSSGRR TP2 molecular association, regulation chromatin organization, altered NPM3(DISRUPTS) 19710011 1 1 0 +POU4F1 POU4F1 Cell development/differentiation; DNA-binding; Transcription factor Q01851 5457 13q31.1 human T39-p 6311909 IRRACLPtPPLQSNL activity, induced cell differentiation, altered; transcription, induced 19135033 1 0 0 activation of galanin promoter induced by retinoic acid +CTTN Cortactin Actin-binding; Cytoskeletal; Motility/polarity/chemotaxis Q14247 2017 11q13.3 human K272-ac 461722 YKTGFGGkFGVQSER HS1_rep molecular association, regulation; intracellular localization cell motility, inhibited ACTB(DISRUPTS) 17643370 1 3 18 Acetylation prevents localization to membrane ruf?es. +SKIL SKIL Cell development/differentiation; Transcription, coactivator/corepressor P12757 6498 3q26.2 human K446-ub 3144804 EKAHSSGkLQKTVSY protein degradation signaling pathway regulation 11691834 1 0 0 TGF-beta signaling +LRRK2 LRRK2 EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, Ser/Thr (non-receptor); Protein kinase, TKL Q5S007 120892 12q12 human S1292-p 13204416 PNEMGKLsKIWDLPL LRR_4 intracellular localization; enzymatic activity, induced cell growth, induced 23241745; 29212815 15 3 0 +RALB RALB G protein; G protein, monomeric; G protein, monomeric, Ras P11234 5899 2q14.2 human K47-ub 40190212 VEDYEPTkADSYRKK Ras molecular association, regulation autophagy, induced; signaling pathway regulation Sec5(INDUCES); EXOC8(DISRUPTS) 24056301 1 1 0 promotes TBK1-IRF3 signaling +WWTR1 TAZ Oncoprotein; Transcription, coactivator/corepressor Q9GZV5 25937 3q25.1 human Y305-p 1876136800 PFLNGGPyHSREQST intracellular localization carcinogenesis, induced; cell growth, induced; apoptosis, inhibited; transcription, induced 35041461 1 1 0 +MIP AQP0 Channel, misc.; Membrane protein, integral; Membrane protein, multi-pass; Transporter, aquaporin family P30301 4284 12q13.3 human S229-p 453400 LLFPRLKsISERLSV molecular association, regulation; protein conformation Calmodulin(DISRUPTS) 27660387 3 3 0 phosphorylation of AQP0 disrupts calcium sensitivity by altering the AQP0-CaM interaction interface +CASP9 CASP9 Apoptosis; EC 3.4.22.62; Protease P55211 842 1p36.21 human Y153-p 455198 RGNADLAyILSMEPC activity, induced; molecular association, regulation; enzymatic activity, inhibited apoptosis, induced p53(INDUCES) 15657060; 29066624 2 1 0 +RAP1GAP RAP1GAP GAP; GAP, Ras; Motility/polarity/chemotaxis P47736 5909 1p36.12 human S499-p 3190708 PFGSRRSsAIGIENI activity, induced 19218462 4 25 25 increased Rap1 activity +Cit CRIK EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, AGC; Protein kinase, Ser/Thr (non-receptor) P49025 12704 5|5 F mouse Y1237-p 477284 TERSDLEyQLENIQV molecular association, regulation cell cycle regulation RHOA(INDUCES) 27551053 1 3 1 prevents the completion of cytokinesis +Slc6a3 DAT Membrane protein, integral; Membrane protein, multi-pass; Transporter; Transporter, SLC family P23977 24898 1p11 rat T53-p 6843600 TLINPPQtPVEAQER activity, induced 22722938 5 2 0 dopamine transporter activity +BORA BORA Activator Q6PGQ7 79866 13q21.33 human S325-p 4753166 SPYIDGCsPIKNWSP molecular association, regulation DNA repair, inhibited MDC1(INDUCES) 25742493 1 17 3 +Gja1 GJA1 Channel, misc.; Membrane protein, integral; Membrane protein, multi-pass; Motility/polarity/chemotaxis P08050 24392 20q11 rat S257-p 465456 TTGPLSPsKDCGSPK activity, inhibited 16000550 2 8 0 MAPK1 mediated phosphorylatiion of Cx43 inducing inhibition of myometrial gap junctions. +HAVCR2 TIM-3 Membrane protein, integral; Receptor, misc. Q8TDQ0 84868 5q33.3 human Y272-p 26371002 YTIEENVyEVEEPNE receptor inactivation, induced; molecular association, regulation; intracellular localization signaling pathway regulation; transcription, inhibited STAT1(INDUCES); Fyn(INDUCES); P38A(INDUCES); PIK3R1(INDUCES) 26492563; 27757304; 31848194 4 0 0 suppresses TCR-mediated activation of the NF-kB/NFAT reporter activity; PI3K-Akt-mTOR pathway for NK cells in liver; Galectin-9 increased the binding between Tim-3- and STAT1, nuclear localization of STAT1 is linhibited, enhanced SOCS1 expression +GATA1 GATA1 DNA-binding; Transcription factor P15976 2623 Xp11.23 human K314-ac 459194 RKASGKGkKKRGSSL molecular association, regulation transcription, altered DNA(INDUCES) 16888089 3 1 0 +TTK TTK Cancer Testis Antigen (CTA); EC 2.7.12.1; KINASE; Kinase, protein; Protein kinase, Other; Protein kinase, dual-specificity (non-receptor) P33981 7272 6q14.1 human S321-p 3189826 SKPSGNDsCELRNLK intracellular localization; enzymatic activity, induced cell cycle regulation 25265012; 26119734 2 10 0 regulates spindle assembly checkpoint and recruitment of SAC proteins; autophosphorylation of this site is required for release TTK from kinetochore; causes decreased kinetochore localization of BubR1 and Mad2. +RIPK1 RIPK1 EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, Ser/Thr (non-receptor); Protein kinase, TKL Q13546 8737 6p25.2 human K604-ub 2188100 HWKNCARkLGFTQSQ Death protein degradation 35711363 3 2 0 degradation and inhibited necroptosis +Capn2 CAPN2 EC 3.4.22.53; Motility/polarity/chemotaxis; Protease O08529 12334 1|1 H5 mouse S50-p 451162 GALFQDPsFPALPSS Peptidase_C2 intracellular localization 16809781 3 1 0 +Zdhhc3 ZDHHC3 EC 2.3.1.225; Membrane protein, integral; Membrane protein, multi-pass; Transferase Q8R173 69035 9|9 F4 mouse Y297-p 56580000 GKADPYQyVV_____ enzymatic activity, inhibited cytoskeletal reorganization 27247265 1 0 0 neurite outgrowth; palmitoylation +EGFR EGFR EC 2.7.10.1; KINASE; Kinase, protein; Membrane protein, integral; Oncoprotein; Protein kinase, TK; Protein kinase, tyrosine (receptor) P00533 1956 7p11.2 human K846-ub 1065313 AARNVLVkTPQHVKI PK_Tyr_Ser-Thr protein degradation 17940017 1 3 0 +CERS2 LASS2 DNA-binding; Membrane protein, integral; Membrane protein, multi-pass; Transferase Q96G23 29956 1q21.3 human S349-p 469771 DREETESsEGEEAAA enzymatic activity, induced 26887952 1 43 198 +RBBP8 CtIP EC 3.1.-.-; Transcription, coactivator/corepressor Q99708 5932 18q11.2 human K578-sm 55429361 NKPSLQIkEENAVFK molecular association, regulation; ubiquitination DNA repair, induced RNF4(INDUCES) 33406258; 33723063 2 1 0 protects stalled replication forks from over-resection; colocalizes with RFA2; promotes DNA end resection, and substituting K578 with arginine results in impaired end resection and HR activity +Pdx1 PDX1 DNA-binding; Transcription factor P52947 29535 12p11 rat S268-p 11279404 LPSGLSAsPQPSSIA protein degradation 19833727 3 4 0 +Aire AIRE Transcription factor Q9Z0E3 11634 10 C1|10 39.72 cM mouse T69-p 1191300 ALLSWLLtRDSGAIL HSR molecular association, regulation transcription, induced CDK9(INDUCES); CBP(INDUCES); BRD4(INDUCES) 26216992 3 1 0 recruits Brd4 +EPOR EPOR Membrane protein, integral; Receptor, cytokine P19235 2057 19p13.2 human Y485-p 3103701 GGLSDGPySNPYENS apoptosis, inhibited 14662339 3 0 0 +RIPK1 RIPK1 EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, Ser/Thr (non-receptor); Protein kinase, TKL Q13546 8737 6p25.2 human S25-p 27116402 LESAELDsGGFGKVS PK_Tyr_Ser-Thr molecular association, regulation; enzymatic activity, inhibited; phosphorylation apoptosis, inhibited FADD(INDUCES); CASP8(INDUCES) 34862394 3 4 0 inhibits autophosphorylation at S166 +ATM ATM DNA repair, damage; EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, Ser/Thr (non-receptor); Protein kinase, atypical; Tumor suppressor Q13315 472 11q22.3 human S1270-p 1881548600 SHFDEVKsIANQIQE protein degradation; ubiquitination carcinogenesis, induced; cell growth, induced; apoptosis, inhibited; DNA repair, inhibited; transcription, altered 37075701 1 1 0 +DAB1 DAB1 Adaptor/scaffold O75553 1600 1p32.2-p32.1 human Y232-p 447961 SQKKEGVyDVPKSQP molecular association, regulation CRK(INDUCES) 15316068 13 5 12 +PIK3R1 PIK3R1 KINASE; Kinase, lipid; Motility/polarity/chemotaxis P23727 282307 cow S83-p 471075 YIGRKKIsPPTPKPR molecular association, regulation; phosphorylation; enzymatic activity, induced cell cycle regulation; apoptosis, induced; apoptosis, inhibited HRas(INDUCES); PKAR2B(INDUCES); ER-alpha(INDUCES) 17016431; 17043656 3 1 1 Phosphorylation affects survival in thyroid stimulating hormone or cAMP (S83A = reduced survival, S83D = reduced apoptosis). S83A mutant slows S-G2/M progression, and reduces AKT phosphorylation. Enzymatic activation in TSH (not via EGF); cAMP-induced protection from apoptosis was less efficient in S83A and more efficient in S83D. S83A mutants do not arrest in G1 in presence of cAMP where as S83D accumulate in G1 (even in absence of cAMP). cAMP-stimulated phosphorylation of this site leads to Akt1 and GSK3a activation, and binding to p21Ras and estrogen receptor. +ELMO2 ELMO2 Cytoskeletal; Motility/polarity/chemotaxis Q96JJ3 63916 20q13.12 human Y713-p 477009 IPKEPSSyDFVYHYG carcinogenesis, induced; cell motility, induced 25332238 2 3 16 +RACK1 RACK1 Adaptor/scaffold; G protein; G protein, heterotrimeric; G protein, heterotrimeric beta; Motility/polarity/chemotaxis; Nuclear receptor co-regulator P63244 10399 5q35.3 human S122-ga 1883988600 SDNRQIVsGSRDKTI protein stabilization 36658304 1 0 0 circVPRBP dramatically reduces the S122 O-GlcNAcylation by blocking site to promote RACK1 degradation +ICAM1 ICAM1 Cell adhesion; Immunoglobulin superfamily; Membrane protein, integral P05362 3383 19p13.2 human Y501-p 450969 GTAGLSTyLYNRQRK TM protein processing 14973144 1 0 0 proteolytic cleavage +RASGRP1 RASGRP1 GEF; GEF, Ras O95267 10125 15q14 human T184-p 456226 RDWSRKLtQRIKSNT signaling pathway regulation 15899849 3 0 0 +Grin2a NMDAR2A Channel, ligand-gated; Membrane protein, integral; Membrane protein, multi-pass Q00959 24409 10q11 rat S1232-p 448260 SGHFTMRsPFKCDAC NMDAR2_C activity, induced; intracellular localization neural plasticity 11675505; 22870316; 24769228 6 1 7 +NINL Nlp Cell cycle regulation; Microtubule-binding Q9Y2I6 22981 20p11.21 human S585-p 15668108 RLPKNRHsPSWSPDG intracellular localization cell cycle regulation 20864540 1 1 0 +GRB7 GRB7 Adaptor/scaffold; Motility/polarity/chemotaxis Q14451 2886 17q12 human S194-p 58912301 KYELFKSsPHSLFPE protein degradation; molecular association, regulation; ubiquitination cell cycle regulation PIN1(INDUCES) 27658202 1 0 0 +CASP8 CASP8 Apoptosis; EC 3.4.22.61; Protease Q14790 841 2q33.1 human S347-p 450983 FTGLKCPsLAGKPKV Peptidase_C14 activity, inhibited apoptosis, inhibited 14970175 1 0 0 +ADRA1D ADRA1D GPCR, family 1; Membrane protein, integral; Membrane protein, multi-pass; Receptor, GPCR P25100 146 20p13 human S334-p 1424270003 HTFRSSLsVRLLKFS 7tm_1 receptor internalization, altered signaling pathway regulation 29551601 1 1 0 regulates ERK signaling pathway, induces calcium signaling de-sensitization +Epor EPOR Membrane protein, integral; Receptor, cytokine P14753 13857 9 A3|9 7.93 cM mouse Y503-p 449885 SEPLHPGyVACS___ molecular association, regulation; receptor internalization, altered apoptosis, altered; signaling pathway regulation PLCG1(INDUCES); PIK3R2(INDUCES); PIK3R1(INDUCES) 15953601; 16380376; 19336760; 21255641 9 0 0 activates PI3K/Akt pathway in signaling by myeloproliferative disorder-associated Jak2 V617 mutant +MRE11 MRE11A Cell cycle regulation; DNA repair, damage; DNA-binding; Deoxyribonuclease P49959 4361 11q21 human S590-p 11506401 NSASRGGsQRGRADT molecular association, regulation DNA(DISRUPTS) 19709933 1 0 0 +MAP2K4 MKK4 EC 2.7.12.2; KINASE; Kinase, protein; Protein kinase, STE; Protein kinase, dual-specificity (non-receptor) P45985 6416 17p12 human Y307-p 1881548608 LATGRFPyPKWNSVF enzymatic activity, inhibited carcinogenesis, inhibited; apoptosis, induced; transcription, inhibited 37020040 1 1 0 +GADD45GIP1 GADD45GIP1 Cell cycle regulation; Nuclear receptor co-regulator Q8TAE8 90480 19p13.13 human S221-p 474542 PAASGAPsS______ cell growth, altered 17069992 1 0 0 promotes cell proliferation +Junb JunB Motility/polarity/chemotaxis; Oncoprotein; Transcription factor P09450 16477 8 C3|8 41.41 cM mouse K237-sm 3144820 SRGASAFkEEPQTVP Jun intracellular localization transcription, induced 18424718 1 2 0 +FPR1 FPR1 GPCR, family 1; Membrane protein, integral; Membrane protein, multi-pass; Motility/polarity/chemotaxis; Receptor, GPCR P21462 2357 19q13.41 human T329-p 450665 RALTEDStQTSDTAT receptor desensitization, altered; receptor internalization, altered 10514456 2 1 0 +SDCBP syntenin Adaptor/scaffold; Cell adhesion; Cytokine; Membrane protein, integral; Motility/polarity/chemotaxis; Vesicle O00560 6386 8q12.1 human Y46-p 455029 IPHDGNLyPRLYPEL endocytosis, induced; exocytosis, induced 29109268; 33732417 2 16 490 +KDM1A LSD1 DEMETHYLASE; Demethylase; EC 1.-.-.-; Nuclear receptor co-regulator; Oxidoreductase; Transcription factor O60341 23028 1p36.12 human K114-m2 53529105 GRRTSRRkRAKVEYR molecular association, regulation; intracellular localization CHD-1(INDUCES) DNA(INDUCES) 26751641 1 1 0 +PKP1 plakophilin 1 Cell adhesion; Motility/polarity/chemotaxis Q13835 5317 1q32.1 human S191-p 15405309 YSFYSTCsGQKAIKK activity, induced; protein stabilization cell motility, induced; cell growth, induced; translation, induced; cell adhesion, inhibited 23444369 1 2 17 +CYLD CYLD DEUBIQUITINASE; EC 3.4.19.12; Protease; Tumor suppressor; Ubiquitin conjugating system; Ubiquitin-specific protease Q9NQC7 1540 16q12.1 human S439-p 12173911 SIGHSPLsLSAQSVM CYLD_phos_site ubiquitination 15870263 2 1 0 induces ubiquitination of TRAF2 +HNRNPK hnRNP K RNA splicing; RNA-binding; Spliceosome P61978 3190 9q21.32 human S116-p 452369 EEGLQLPsPTATSQL protein degradation; intracellular localization cell growth, induced; transcription, induced 20960454; 24236111; 28423622 4 38 22 localized to nuclear matrix +Ntrk1 TrkA EC 2.7.10.1; KINASE; Kinase, protein; Membrane protein, integral; Oncoprotein; Protein kinase, TK; Protein kinase, tyrosine (receptor) P35739 59109 2q34 rat Y499-p 447762 HIMENPQyFSDTCVH molecular association, regulation; enzymatic activity, induced cell differentiation, altered; cell growth, altered SHC3(INDUCES); SHC2(INDUCES) 11238898; 12006576; 8156997 23 0 2 +LY6G6F G6f Cell surface; Membrane protein, integral Q5SQ64 259215 6p21.33 human Y281-p 450289 FKPEIQVyENIHLAR molecular association, regulation; phosphorylation GRB2(INDUCES); GRB7(INDUCES) 12852788; 16941570 3 2 8 +PAQR3 PAQR3 Membrane protein, integral; Membrane protein, multi-pass; Receptor, misc. Q6TCH7 152559 4q21.21 human T32-p 53998800 PRGIRLYtYEQIPGS intracellular localization; phosphorylation autophagy, induced 26834238 1 0 0 punctiform distribution of PAQR3 upon glucose starvation, ; PAQR3 T32- affects Beclin1 S93 phosphorylation +CDKN1A p21Cip1 Cell cycle regulation; Inhibitor P38936 1026 6p21.2 human K141-ub 9897002 PGDSQGRkRRQTSMT protein degradation; ubiquitination 13678583; 17429006 4 0 0 under chelated Fe2+ conditions p21Cip1 is degraded by ubiquitin independent proteasomal degradation.; UV-induced +PIK3CG PIK3CG Autophagy; Carbohydrate Metabolism - inositol phosphate; EC 2.7.1.153; EC 2.7.11.1; KINASE; Kinase, lipid; Motility/polarity/chemotaxis; Protein kinase, Ser/Thr (non-receptor) P48736 5294 7q22.3 human S582-p 28702402 LWHFRYEsLKHPKAY PI3Ka molecular association, regulation; enzymatic activity, induced signaling pathway regulation PIK3R6(DISRUPTS) 23824069 1 1 0 GPCR-mediated p110gamma signaling; disrupts immune cell responses activated by G protein-coupled receptors (GPCRs) +GRB10 GRB10 Adaptor/scaffold Q13322 2887 7p12.1 human S104-p 483656 RSIQPQVsPRQRVQR protein stabilization 21659604 1 22 1 +BAP1 BAP1 DEUBIQUITINASE; EC 3.4.19.12; Protease; Tumor suppressor; Ubiquitin conjugating system; Ubiquitin-specific protease Q92560 8314 3p21.1 human S276-p 31012814 ELIQTHKsQESQLPE intracellular localization DNA repair, induced 24347639 1 3 0 +PHF20 PHF20 ACETYLTRANSFERASE; Acetyltransferase; C2H2-type zinc finger protein; DNA-binding; Nuclear envelope Q9BVI0 51230 20q11.22-q11.23 human S291-p 23303200 ELRRRKIsKGCEVPL protein degradation; molecular association, regulation; intracellular localization cell cycle regulation; carcinogenesis, induced; cell growth, induced; apoptosis, inhibited; transcription, inhibited DNA(DISRUPTS) 22334668; 22975685 2 0 0 induces degradation of p53 +Map3k12 DLK EC 2.7.11.25; KINASE; Kinase, protein; Protein kinase, Ser/Thr (non-receptor); Protein kinase, TKL Q60700 26404 15|15 F3 mouse S302-p 4727859 SDKSTKMsFAGTVAW PK_Tyr_Ser-Thr protein stabilization 23979718 1 1 2 +Tub tubby Lipid-binding; Membrane protein, peripheral P50586 22141 7 E3|7 57.21 cM mouse Y464-p 34823401 IHGNDPDyIVMQFGR Tub intracellular localization 25031889 1 0 0 translocation to the nucleus +Atf1 ATF-1 Transcription factor P81269 11908 15|15 F1 mouse S63-p 449762 GILARRPsYRKILKD pKID molecular association, regulation; acetylation cell growth, inhibited DNA(DISRUPTS) 25312646 20 2 29 HSF1 acetylation, Decreased cell survival, disrupts HSF1 binding to HSP70 promoter +SPAG5 SPAG5 Cell cycle regulation Q96R06 10615 17q11.2 human S974-p 1261100 EESLAEMsIMTTELQ intracellular localization 18055457 1 0 0 required for SPAG5 localization to the spindle apparatus during mitosis +CDC25C CDC25C EC 3.1.3.48; Motility/polarity/chemotaxis; PHOSPHATASE; Protein phosphatase, dual-specificity P30307 995 5q31.2 human S168-p 449022 SEMKYLGsPITTVPK enzymatic activity, inhibited cell cycle regulation; cell adhesion, altered 20220133; 8119945 4 15 59 +NPM1 NPM1 Nucleolus; Oncoprotein; RNA-binding; Translation P06748 4869 5q35.1 human S125-p 459897 AVEEDAEsEDEEEED molecular association, regulation; intracellular localization; phosphorylation cell cycle regulation; carcinogenesis, induced; cell motility, induced; cell growth, induced; apoptosis, inhibited; transcription, induced; signaling pathway regulation Other(INDUCES) 24857377; 30453269; 32606971; 36563749 11 95 558 induces binding to HIV1 TAT ; induces ERK phosphorylation and NFKB translocation thus inducing ERK/NF-K? signaling +SCD SCD EC 1.14.19.1; Endoplasmic reticulum; Lipid Metabolism - unsaturated fatty acid biosynthesis; Membrane protein, integral; Membrane protein, multi-pass; Oxidoreductase O00767 6319 10q24.31 human Y55-p 3411245 PDIKDDIyDPTYKDK protein stabilization cell cycle regulation; cell growth, induced; apoptosis, induced 28724430 1 2 6 +ZNF281 ZNF281 C2H2-type zinc finger protein; DNA-binding; Transcription factor Q9Y2X9 23528 1q32.1 human S785-p 472466 SSAFQSSsQKLTSQK intracellular localization DNA repair, induced 31570788 1 3 1 +Hcn2 HCN2 Channel, cation; Membrane protein, integral; Membrane protein, multi-pass O88703 15166 10|10 C1 mouse S861-p 1871246002 SARSRLSsNL_____ activity, induced 33240105 1 0 0 Induced HCN2 current +N Nucleocapsid Protein P59595 1489678 SARSCoV1 S189-p 1868301201 QASSRSSsRSRGNSR CoV_nucleocap molecular association, regulation Nucleocapsid Protein(INDUCES) 23717688 3 3 0 di-domain self-association +Cdh1 CDH1 Cell adhesion; Membrane protein, integral; Motility/polarity/chemotaxis; UBIQUITIN LIGASE; Ubiquitin ligase P09803 12550 8 D3|8 53.18 cM mouse S846-p 478354 GSGSEAAsLSSLNSS CADH_Y-type_LIR intracellular localization 24063632 4 0 0 internalization of E-cadherin off the cell surface +Rps6kb1 p70S6K EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, AGC; Protein kinase, Ser/Thr (non-receptor); Translation Q8BSK8 72508 11|11 C mouse S489-gl 1869633703 EQMDVTVsGEASAPL phosphorylation signaling pathway regulation 32601203 1 0 0 supresses mTORC1/S6K1 signaling and p70S6K phosphorylation at S418 and T229, regulates macrophage pro-inflammatory signaling, +Oprm1 MOR-1 GPCR, family 1; Membrane protein, integral; Membrane protein, multi-pass; Receptor, GPCR P42866 18390 10 A1|10 1.85 cM mouse S363-p 447783 STIEQQNsARIRQNT receptor recycling, induced 25801029; 31575621 11 6 0 +YBX1 YB-1 RNA processing; RNA splicing; RNA-binding; Transcription factor P67809 4904 1p34.2 human S174-p 469055 SGEKNEGsESAPEGQ transcription, altered 31387591 2 67 31 downregulation of synaptopodin, nephrin and podocin expression +FOXO4 FOXO4 DNA-binding; Oncoprotein; Transcription factor P98177 4303 Xq13.1 human K407-ac 459044 GGLPSSSkLATGVGL activity, inhibited transcription, inhibited 12964026 2 0 0 +Runx2 AML3 iso5 DNA-binding; Transcription factor Q08775-5 12393 17 B3|17 21.33 cM mouse K202-ub 1873375610 VGRSGRGkSFTLTIT Runt cell differentiation, induced; transcription, induced 28500134 1 0 0 +Pcna PCNA Cell cycle regulation; DNA replication P17918 18538 2 F2|2 64.15 cM mouse Y211-p 471414 HLTFALRyLNFFTKA PCNA_C enzymatic activity, induced; phosphorylation carcinogenesis, induced; cell motility, induced; transcription, altered; signaling pathway regulation; cell growth, induced; apoptosis, inhibited; DNA repair, inhibited; transcription, inhibited 34433039; 35628489 7 2 2 induces ALDH activity; inhibits H2AX, TBK1, IRF3 and ATM phosphorylation, regulates cGAS-TBK1-IRF3 pathway +GMPR GMPR EC 1.7.1.7; Nucleotide Metabolism - purine; Oxidoreductase P36959 2766 6p22.3 human Y267-p 1005248 GRKLKLFyGMSSDTA IMPDH molecular association, regulation; enzymatic activity, induced carcinogenesis, inhibited RAC1(INDUCES) 35148834 1 2 0 +E2F1 E2F1 DNA-binding; Transcription factor Q01094 1869 20q11.22 human T433-p 447871 DCDFGDLtPLDF___ protein degradation; ubiquitination; intracellular localization cell differentiation, altered; autophagy, inhibited; signaling pathway regulation 10428966; 18794805; 27903963; 33174204 5 0 0 E2F1-autophagy-E2F7a pathway +UMPS UMPS EC 2.4.2.10; EC 4.1.1.23; Lyase; Nucleotide Metabolism - pyrimidine; Transferase; Xenobiotic Metabolism - drug metabolism - other enzymes P11172 7372 3q21.2 human S214-p 3180453 VAANHNGsPLSIKEA enzymatic activity, inhibited 37291265 1 15 1 +Jam2 JAM2 Cell adhesion; Membrane protein, integral Q9JI59 67374 16|16 C3.3 mouse S280-p 11263901 FQKGSPAsKVTTMSE intracellular localization 12953056 1 0 0 S280A mutant localized at cell-cell contacts +KDM3A JMJD1A DEMETHYLASE; Demethylase; EC 1.14.11.-; Nuclear receptor co-regulator; Oxidoreductase Q9Y4C1 55818 2p11.2 human S265-p 453894 GAVKRKSsENNGTLV molecular association, regulation cell cycle regulation; RNA splicing, induced; transcription, induced ARID1A(INDUCES); PPAR-gamma(INDUCES); PRDM16(INDUCES) 25948511; 29674659; 34321328 3 4 1 +Srgap3 ARHGAP14 GAP; GAP, Rac/Rho Q812A2 259302 6|6 E3 mouse S858-p 3175109 MGRVRLRsDGAAIPR enzymatic activity, induced cell motility, altered 26499801 1 20 24 S858A enhanced cell migration +MAP3K3 MEKK3 EC 2.7.11.25; KINASE; Kinase, protein; Protein kinase, STE; Protein kinase, Ser/Thr (non-receptor) Q99759 4215 17q23.3 human T294-p 2243102 DYSDGRRtFPRIRRH molecular association, regulation 14-3-3 beta(INDUCES) 18308725 1 4 1 facilitated by phosphorylation of S526 +MEF2B MEF2B iso2 DNA-binding; Transcription factor Q02080-2 100271849 19p13.11 human S324-p 29649500 SIKSERLsPAPGGPG sumoylation transcription, inhibited 23974956 1 2 0 Phosphorylation-dependent sumoylation inhibited transcription. ; increases sumoylation at MEF2B iso2-K319 +TTK TTK Cancer Testis Antigen (CTA); EC 2.7.12.1; KINASE; Kinase, protein; Protein kinase, Other; Protein kinase, dual-specificity (non-receptor) P33981 7272 6q14.1 human S333-p 41389702 NLKSVQNsHFKEPLV intracellular localization; enzymatic activity, induced 26119734 1 1 0 regulates spindle assembly checkpoint and recruitment of SAC proteins +GUCA1B GCAP2 Calcium-binding Q9UMX6 2979 6p21.1 human S197-p 455322 LAQQRRKsAMF____ intracellular localization 29440717 3 0 0 phosphomimetic S201 is suffcient to retain GCAP2 at inner rod segments +MISP MISP Unknown function Q8IVT2 126353 19p13.3 human S394-p 457010 PGLRRALsSDSILSP AKAP2_C cytoskeletal reorganization 34023777 1 35 101 +CYCS CYCS Apoptosis; Mitochondrial; Oxidoreductase; PHOSPHATASE; Protein phosphatase, Ser/Thr (non-receptor) P00004 100053958 horse K88-ac 1968623 MIFAGIKkKTEREDL Cytochrom_C enzymatic activity, induced 19645667 1 2 0 +Spi1 PU.1 DNA-binding; Oncoprotein; Transcription factor Q6BDS1 rat S147-p 455900 QSPPLEVsDGEADGL molecular association, regulation IRF8(INDUCES) 15688197 6 4 0 +AJUBA JUB Cell adhesion; Motility/polarity/chemotaxis; Transcription, coactivator/corepressor Q96IF1 84962 14q11.2 human S119-p 483805 EPTAPALsPRSSFAS cell cycle regulation; cell growth, induced 27226586 1 28 0 mitotic phosphorylation promotse cell proliferation and anchorage-independent growth +RPE65 RPE65 Cofactor and Vitamin Metabolism - retinol; EC 3.1.1.64 Q16518 6121 1p31.3 human C112-pa 12559508 TCAFPDPcKNIFSRF RPE65 intracellular localization; enzymatic activity, induced 19049981 1 1 0 membrane localization +Pecam1 PECAM-1 Cell adhesion; Cell development/differentiation; Membrane protein, integral; Motility/polarity/chemotaxis Q08481 18613 11|11 E1 mouse Y702-p 448760 TRATETVySEIRKVD molecular association, regulation cell adhesion, altered SHP-2(INDUCES); SHP-1(INDUCES) 9298995; 9624175 14 20 786 Y702 A.K.A. Y686; induces switch from heterophilic to homophilic cell-cell aggregation +JUN Jun Oncoprotein; Transcription factor P05412 3725 1p32.1 human T231-p 455366 ALKEEPQtVPEMPGE Jun molecular association, regulation; activity, inhibited transcription, altered SP1(DISRUPTS) 1516134; 17215518 3 0 0 +Trim28 TIF1B EC 6.3.2.-; KINASE; Kinase, protein; Ligase; Nuclear receptor co-regulator; Protein kinase, atypical; SUMO LIGASE; SUMO ligase; Transcription, coactivator/corepressor; UBIQUITIN LIGASE; Ubiquitin conjugating system; Ubiquitin ligase Q62318 21849 7|7 A1 mouse K676-sm 3142607 CHVLPDLkEEDGSLS transcription, inhibited 17298944 2 2 0 +SCML2 SCML2 Transcription factor Q9UQR0 10389 Xp22.13 human T305-p 3216633 SSSVKNItPRKKGPN RBR cell cycle regulation 24358021 1 3 10 +STAT2 STAT2 DNA-binding; Transcription factor P52630 6773 12q13.3 human Y690-p 448193 NLQERRKyLKHRLIV intracellular localization transcription, induced 15767445; 36148221 19 0 0 +Arhgdia RhoGDI alpha Apoptosis; Cell adhesion; Cell development/differentiation; G protein regulator, misc.; Motility/polarity/chemotaxis Q5XI73 360678 10q32.3 rat S101-p 452195 LESFKKQsFVLKEGV Rho_GDI molecular association, regulation cell growth, altered RAC1(DISRUPTS); CDC42 iso1(DISRUPTS) 19103160 6 11 1 in response to bFGF stimulation +PHGDH PHGDH Amino Acid Metabolism - glycine, serine and threonine; Cell development/differentiation; EC 1.1.1.95; Oxidoreductase O43175 26227 1p12 human T57-p 4730705 GLIVRSAtKVTADVI 2-Hacid_dh carcinogenesis, induced; cell growth, induced; apoptosis, inhibited 23374352 1 3 0 +MAPKAP1 Sin1 Adaptor/scaffold Q9BPZ7 79109 9q33.3 human S186-p 27458520 VYLPLHSsQDRLLPM CRIM molecular association, regulation; phosphorylation apoptosis, inhibited ECT2(INDUCES) 34982576 1 6 0 induces AKT phosphorylation +Dok2 DOK2 Adaptor/scaffold O70469 13449 14 D2|14 36.71 cM mouse Y276-p 452174 LPRPESPySRPHDSL molecular association, regulation cell differentiation, altered; cell growth, altered RASA1(INDUCES) 10428862; 10508618; 12093790 3 0 1 +MAFA MAFA DNA-binding; Oncoprotein; Transcription factor; Tumor suppressor Q8NHW3 389692 8q24.3 human T57-p 456028 LSSTPLStPCSSVPS activity, induced; protein degradation; molecular association, regulation; ubiquitination carcinogenesis, induced; transcription, induced; signaling pathway regulation PCAF(INDUCES) 18042454; 19407223; 23660596; 35406570 8 1 0 Ubiquitin proteosomal pathway +WAS WASP Adaptor/scaffold; Motility/polarity/chemotaxis P42768 7454 Xp11.23 human K147-sm 52504000 LVQEKIQkRNQRQSG molecular association, regulation; acetylation transcription, altered; signaling pathway regulation COMMD1(DISRUPTS); HDAC6(DISRUPTS) 26261240 1 0 0 induces hypoacetylation at H3K14, regulates NF-kB signaling +Arrb2 ARRB2 Adaptor/scaffold Q91YI4 216869 11 B3|11 42.99 cM mouse K171-ub 573763286 SVRLIIRkVQFAPET Arrestin_N protein degradation 33243993 1 1 0 +Kalrn kalirin EC 2.7.11.1; GEF; GEF, Rac/Rho; KINASE; Kinase, protein; Protein kinase, CAMK; Protein kinase, Ser/Thr (non-receptor) P97924 84009 11q22 rat T77-p 1315601 DVCKRGFtVIIDMRG CRAL_TRIO_2 activity, induced cytoskeletal reorganization 18031682 2 0 0 regulates neuronal spines and Rac1 activation +C3AR1 C3aR GPCR, family 1; Membrane protein, integral; Membrane protein, multi-pass; Receptor, GPCR Q16581 719 12p13.31 human S465-p 27145808 FSEELTRsTHCPSNN receptor desensitization, induced; molecular association, regulation transcription, inhibited ARRB2(INDUCES) 23077507 1 0 0 +STAU1 STAU iso2 RNA-binding O95793-2 6780 20q13.13 human T21-p 1877718904 PYSRMQStYNYNMRG dsrm cell growth, induced 35806349 1 0 0 +MCTS1 MCTS1 Cell cycle regulation; Tumor suppressor Q9ULC4 28985 Xq24 human T81-p 26348501 REGPFYPtLRLLHKY Pre-PUA cell growth, induced 17016429 1 0 0 +NUMB NUMB iso3 Cell development/differentiation P49757-3 8650 14q24.2-q24.3 human S284-p 470030 SPFKRQLsLRINELP NumbF molecular association, regulation; intracellular localization endocytosis, inhibited AP2A1(DISRUPTS); CDH1(DISRUPTS); CTNND1(DISRUPTS) 21775625 4 9 17 +TRIM11 TRIM11 EC 6.3.2.-; EC 6.3.2.19; Ligase; UBIQUITIN LIGASE; Ubiquitin conjugating system; Ubiquitin ligase Q96F44 81559 1q42.13 human K458-ub 57951823 PMTICRPkGGSGDTL molecular association, regulation autophagy, induced SQSTM1(INDUCES) 27498865 1 0 0 promotes AIM2 degradation via SQSTM1-dependent autophagy +DRD1 DRD1 GPCR, family 1; Membrane protein, integral; Membrane protein, multi-pass; Receptor, GPCR P21728 1812 5q35.2 human T244-p 1869357204 HAKNCQTtTGNGKPV 7tm_1 molecular association, regulation ARR3(INDUCES) 32503917 1 0 0 +Trex1 TREX1 Cell cycle regulation; DNA repair, damage; DNA-binding; Deoxyribonuclease; EC 3.1.11.2 Q91XB0 22040 9|9 F2 mouse S78-p 2579811 IAPGKACsPGASEIT RNase_T transcription, altered RPN1(DISRUPTS) 28297665 1 9 0 +RND3 RhoE G protein; G protein, monomeric; G protein, monomeric, Rho; Motility/polarity/chemotaxis P61587 390 2q23.3 human S218-p 25307985 QRATKRIsHMPSRPE molecular association, regulation; intracellular localization cell cycle regulation; cytoskeletal reorganization 14-3-3 beta(INDUCES) 23622247; 32041905 2 2 1 +GRK1 GRK1 EC 2.7.11.14; KINASE; Kinase, protein; Protein kinase, AGC; Protein kinase, Ser/Thr (non-receptor) Q15835 6011 13q34 human S5-p 2528801 ___MDFGsLETVVAN molecular association, regulation Rhodopsin(INDUCES) 34262173 2 1 0 +GLI1 GLI1 C2H2-type zinc finger protein; Oncoprotein; Transcription factor P08151 2735 12q13.3 human S1071-p 51348700 SHDQRGSsGHTPPPS protein stabilization 26603838 1 1 0 +CDC25A CDC25A EC 3.1.3.48; Motility/polarity/chemotaxis; PHOSPHATASE; Protein phosphatase, dual-specificity P30304 993 3p21.31 human S18-p 449976 RRLLFACsPPPASQP protein degradation; protein stabilization; ubiquitination cell cycle regulation; apoptosis, inhibited CDK1(INDUCES) 12411508; 34363019 4 6 0 +Cdk2 CDK2 Cell cycle regulation; EC 2.7.11.22; KINASE; Kinase, protein; Protein kinase, CMGC; Protein kinase, Ser/Thr (non-receptor) P97377 12566 10|10 D3 mouse Y15-p 447740 EKIGEGTyGVVYKAK Pkinase enzymatic activity, inhibited cell cycle regulation; cell differentiation, induced; cell growth, altered 11509654; 20462953; 22331465 33 129 3845 regulates centrosome duplication +FERMT2 kindlin-2 Cytoskeletal; Motility/polarity/chemotaxis Q96AC1 10979 14q22.1 human Y193-p 6153405 SKTMTPTyDAHDGSP molecular association, regulation cell motility, induced; cell adhesion, induced FBLIM1(INDUCES) 26037143 1 2 2 FBLM1 is recruited to focal adhesions. required for cell spreading and migration +TET2 TET2 EC 1.14.11.n2; Oxidoreductase; Tumor suppressor Q6N021 54790 4q24 human K110-ac 63106402 LSGLLQIkKLKQDQK protein stabilization; molecular association, regulation; ubiquitination; methylation; enzymatic activity, induced DNA repair, induced DNMT1(INDUCES) DNA(INDUCES) 28107650 1 1 0 inhibits ubiquitination, protects against abnormal DNA methylation +CDKN1A p21Cip1 Cell cycle regulation; Inhibitor P38936 1026 6p21.2 human T55-p 1869957900 RWNFDFVtETPLEGD CDI activity, induced; protein stabilization; molecular association, regulation; intracellular localization cell differentiation, inhibited; cell cycle regulation; cell growth, inhibited; apoptosis, induced; signaling pathway regulation CDK2(INDUCES); MDM2(DISRUPTS); PPAR-gamma(INDUCES); CDK4(INDUCES) 31097688 1 0 0 regulates adipocyte metabolism and obesity +Foxo6 FOXO6 DNA-binding Q70KY4 329934 4|4 D2.1 mouse S184-p 2899100 TPRRRAVsMDNGAKF molecular association, regulation; intracellular localization transcription, induced; transcription, inhibited; transcription, altered DNA(DISRUPTS) 12857750; 15987244; 34082382 3 2 0 +Pde4b PDE4B EC 3.1.4.53; Nucleotide Metabolism - purine; Phosphodiesterase Q8VBU5 18578 4 C6|4 46.99 cM mouse S130-p 468390 SDSDYDLsPKAMSRN enzymatic activity, induced 26192746 1 26 5 +Usf1 USF1 DNA-binding; Transcription factor Q61069 22278 1 H3|1 79.4 cM mouse K235-ac 7378203 DCSMESTkSGQSKGG HLH transcription, altered 19303849 2 1 0 +CACB CACNA1C Channel, calcium; Membrane protein, integral; Membrane protein, multi-pass P15381 100101555 rabbit S533-p 453091 RISKSKFsRYWRRWN activity, inhibited 10692404 3 0 0 +KATNA1 KATNA1 EC 3.6.4.3; Hydrolase; Motility/polarity/chemotaxis O75449 11104 6q25.1 human S109-p 23117380 VPVERRPsPGPRKRQ ubiquitination cell cycle regulation 19287380 1 4 1 +PTEN PTEN Carbohydrate Metabolism - inositol phosphate; EC 3.1.3.16; EC 3.1.3.48; EC 3.1.3.67; Motility/polarity/chemotaxis; Nuclear receptor co-regulator; PHOSPHATASE; Phosphatase, lipid; Tumor suppressor P60484 5728 10q23.31 human S385-p 448650 RYSDTTDsDPENEPF molecular association, regulation; protein stabilization; enzymatic activity, inhibited; protein conformation; phosphorylation; enzymatic activity, altered cell cycle regulation; neural plasticity; chromatin organization, altered PTEN(INDUCES); PTEN(DISRUPTS) DNA(INDUCES) 11035045; 12077256; 17565999; 22413754; 24766807; 36155262 12 10 0 plays an important role in regulating spine density; regulates CHK1 phosphorylation and activation and H2AX phosphorylation; phosphorylation maintains PTEN as a monomer +ATP5IF1 ATPIF1 Inhibitor; Mitochondrial Q9UII2 93974 1p35.3 human S39-p 27444486 NVDRGAGsIREAGGA IATP molecular association, regulation ATP5A1(DISRUPTS); ATP5F1(DISRUPTS) 26387949; 30204502 2 11 0 +Mapk1 ERK2 EC 2.7.11.24; KINASE; Kinase, protein; Protein kinase, CMGC; Protein kinase, Ser/Thr (non-receptor) P63085 26413 16 A3|16 10.53 cM mouse T183-p 447593 HDHTGFLtEYVATRW Pkinase intracellular localization; enzymatic activity, induced carcinogenesis, induced; carcinogenesis, inhibited; cell growth, inhibited; transcription, induced; signaling pathway regulation; transcription, altered; neural plasticity; cell growth, induced; apoptosis, inhibited; cytoskeletal reorganization GAB1(INDUCES) 10593929; 10608864; 10867029; 11934884; 1319055; 15788406; 15975986; 16103085; 19004831; 21562256; 21706057; 21813649; 21887248; 21917714; 25584415; 34191798; 37160873; 7504457 1139 120 2416 +RHOB RHOB G protein; G protein, monomeric; G protein, monomeric, Rho; Motility/polarity/chemotaxis; Tumor suppressor P62745 388 2p24.1 human S185-p 2853110 ALQKRYGsQNGCINC molecular association, regulation; activity, inhibited endocytosis, induced; cytoskeletal reorganization PKN1(DISRUPTS) 18590726; 27503856 2 0 0 S185A mutant blocks NGF induced macropinocytosis +MED14 Trap170 Nuclear receptor co-regulator; Transcription, coactivator/corepressor O60244 9282 Xp11.4 human S986-p 452549 NEDDNPPsPIGGDMM transcription, induced 24049075 1 11 1 +Sstr3 SSTR3 GPCR, family 1; Membrane protein, integral; Membrane protein, multi-pass; Receptor, GPCR P30936 171044 7q34 rat S341-p 456708 RRILLRPsRRVRSQE receptor desensitization, altered; receptor internalization, altered 9295322 1 0 2 +Cldn2 Claudin-2 Cytoskeletal; Membrane protein, integral; Membrane protein, multi-pass O88552 12738 X|X F1 mouse S208-p 21690001 QPLATRSsPRSAQQP molecular association, regulation; intracellular localization LAMP2(DISRUPTS) 22825868 2 4 0 +AKT1 Akt1 EC 2.7.11.1; KINASE; Kinase, protein; Oncoprotein; Protein kinase, AGC; Protein kinase, Ser/Thr (non-receptor) P31749 207 14q32.33 human R15-me 1880119100 KEGWLHKrGEYIKTW molecular association, regulation; intracellular localization carcinogenesis, inhibited; cell motility, inhibited Sin1(INDUCES); PDK1(INDUCES) 35803962 1 0 0 AKT1-Arg 15 methylation is necessary for its translocation to the plasma membrane; PRMT5 KD blocks tumor cell metastasis +Elk1 ELK1 DNA-binding; Transcription factor P41969 13712 X A1.3|X 16.45 cM mouse S423-p 469193 LSTPVVLsPGPQKP_ molecular association, regulation transcription, inhibited Trap100(DISRUPTS); MED23(DISRUPTS); MED16(DISRUPTS) 27738173 2 3 5 +Oprm1 MOR-1 GPCR, family 1; Membrane protein, integral; Membrane protein, multi-pass; Receptor, GPCR P42866 18390 10 A1|10 1.85 cM mouse Y336-p 5397200 SCLNPVLyAFLDENF 7tm_1 activity, induced signaling pathway regulation 24061856 3 0 0 adenylyl cyclase activity increased; Grb/SOS/Ras-Raf1 pathway for conversion of Gi/Go-coupled receptor into RTK +SIRT6 SIRT6 DEACETYLASE; DEUBIQUITINASE; Deacetylase; EC 2.4.2.31; EC 3.5.1.-; Transferase Q8N6T7 51548 19p13.3 human K170-ub 40212801 GRLCTVAkARGLRAC SIR2 protein stabilization DNA repair, induced; transcription, inhibited 24043303 1 3 0 decrease in acetylation +Plk4 PLK4 EC 2.7.11.21; KINASE; Kinase, protein; Nucleolus; Protein kinase, Other; Protein kinase, Ser/Thr (non-receptor) Q64702 20873 3|3 B mouse S282-p 12654003 DVGTVEDsMDSGHAT protein degradation; ubiquitination 20100909 1 1 0 +TRAF3 TRAF3 UBIQUITIN LIGASE; Ubiquitin conjugating system; Ubiquitin ligase Q13114 7187 14q32.32 human S75-p 1875793002 CGHRFCEsCMAALLS cell growth, induced; apoptosis, inhibited; transcription, induced; signaling pathway regulation 34255829 0 1 0 induces NIK stabilization and NF-kB signaling +KCNJ11 Kir6.2 Channel, potassium; Membrane protein, integral; Membrane protein, multi-pass Q14654 3767 11p15.1 human T224-p 453090 MQVVRKTtSPEGEVV IRK_C receptor internalization, induced; activity, inhibited 23223335; 24101510 3 0 0 channel current is inhibited +Itk ITK EC 2.7.10.2; KINASE; Kinase, protein; Protein kinase, TK; Protein kinase, tyrosine (non-receptor) Q03526 16428 11 B1.1|11 27.75 cM mouse Y186-p 449834 ETLVIALyDYQTNDP SH3_1 phosphorylation 12842872 3 0 80 Itk Y186F retains partial activity; stimulates ERK phosphorylation +ULK1 ULK1 Autophagy; EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, Other; Protein kinase, Ser/Thr (non-receptor) O75385 8408 12q24.33 human S410-gl 1880900308 SPSPPCSsSPSPSGR protein stabilization; molecular association, regulation; phosphorylation autophagy, induced STX17(INDUCES); HSC70(DISRUPTS) 35931119 1 0 0 inhibits phosphorylation at S423 +TRPV6 TRPV6 Channel, calcium; Membrane protein, integral; Membrane protein, multi-pass Q9H1D0 55503 7q34 human T728-p 12173902 MPSVSRStSRSSANW activity, inhibited 19805577 1 0 0 involved in regulation of calcium influx by ATP +Tnnt2 TNNT2 Motility/polarity/chemotaxis; Motor P50752 21956 1 E4|1 59.32 cM mouse T207-p 449038 YIQKQAQtERKSGKR Troponin activity, induced 12832403 6 0 0 +Foxo1 FOXO1A DNA-binding; Nuclear receptor co-regulator; Oncoprotein; Transcription factor Q9R1E0 56458 3 C|3 23.19 cM mouse S319-p 449112 PRTSSNAsTISGRLS transcription, inhibited 12724332; 22848439 6 1 0 enhances hypoglycemic effect +ENG ENG Membrane protein, integral; Motility/polarity/chemotaxis; Receptor, misc. P17813 2022 9q34.11 human S634-p 465618 VAVAAPAsSESSSTN phosphorylation 16785228 1 1 0 required for threonine phosphorylation of ENG +Yap1 YAP1 Oncoprotein; Transcription, coactivator/corepressor Q2EJA0 363014 8q11 rat S363-p 3190672 TYHSRDEsTDSGLSM protein degradation apoptosis, induced; transcription, inhibited 27194756; 33568044 32 13 5 +SLC12A6 KCC3 Membrane protein, integral; Membrane protein, multi-pass; Transporter; Transporter, SLC family Q9UHW9 9990 15q14 human T991-p 4770536 SAYTYERtLMMEQRS SLC12 molecular association, regulation; activity, inhibited STLK3(INDUCES) 19665974; 24043619; 27485015; 27782176 5 13 1 +SYN1 SYN1 Vesicle P17599 281510 cow S553-p 448377 TRPPASPsPQRQAGP molecular association, regulation ACTB(INDUCES) 24849359 8 22 10 polymerized actin +IGBP1 IGBP1 Motility/polarity/chemotaxis; Phosphatase, regulatory subunit P78318 3476 Xq13.1 human K287-ub 21176770 LPDQGIAkAAPEEFR TAP42 protein degradation 23740247 1 4 0 +Il21r IL21R Membrane protein, integral; Receptor, cytokine Q9JHX3 60504 7|7 F3 mouse Y281-p 1270907 ESFFQPLyREHSGNF cell growth, altered 17234735 1 0 0 +Irs1 IRS1 Adaptor/scaffold; Motility/polarity/chemotaxis P35569 16367 1 C5|1 42.0 cM mouse S635-p 447507 YMPMSPKsVSAPQQI protein degradation signaling pathway regulation 15994203; 23142081; 31672472; 34234788 35 4 0 +SH3GLB1 endophilin B1 Apoptosis; Autophagy; EC 2.3.1.-; Mitochondrial; Transferase Q9Y371 51100 1p22.3 human T145-p 26318403 TSALNFLtPLRNFIE BAR receptor internalization, inhibited autophagy, inhibited; endocytosis, inhibited 27715385 2 0 0 +EXOSC9 EXOSC9 EC 3.1.13.-; Nucleolus; RNA processing; Ribonuclease Q06265 5393 4q27 human S394-p 3194468 APIILSDsEEEEMII molecular association, regulation SUMO2(INDUCES); SUMO1(INDUCES) 19217413 1 19 1 +RPS6KA1 p90RSK EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, AGC; Protein kinase, Ser/Thr (non-receptor); Translation Q15418 6195 1p36.11 human S380-p 447990 HQLFRGFsFVATGLM Pkinase_C protein degradation; ubiquitination; enzymatic activity, induced; phosphorylation cell motility, induced; transcription, induced; signaling pathway regulation 21183680; 30586719; 36791912; 37059179 66 48 64 ERK phosphorylation; induces EphA2 phosphorylation; PKC-ERK-Runx2-TGF?R1 signaling pathway +Ctnnd2 CTNND2 Actin-binding; Motility/polarity/chemotaxis O35927 18163 15|15 B2 mouse S300-p 14910701 RGSSPKQsPSRLAKS molecular association, regulation; intracellular localization cytoskeletal reorganization PSD-95(DISRUPTS); GRIP1(DISRUPTS) 20573893 1 1 1 +TRIM21 TRIM21 EC 6.3.2.-; Ligase; UBIQUITIN LIGASE; Ubiquitin conjugating system; Ubiquitin ligase P19474 6737 11p15.4 human K387-ac 1875282502 IWLWNKQkYEAGTYP SPRY molecular association, regulation TRIM21(DISRUPTS) 32796032 1 0 0 induces the antibody-dependent intracellular neutralization (ADIN) of the nonenveloped DNA virus adenovirus (AdV) type 5 ; Hyperacetylation of TRIM21 bLocks dimerization and ubiquitinalion +Cad CAD Amino Acid Metabolism - alanine, aspartate and glutamate; EC 2.1.3.2; EC 3.5.2.3; EC 6.3.5.5; Hydrolase; KINASE; Ligase; Nucleotide Metabolism - pyrimidine; Transferase P08955 101843763 hamster T456-p 451248 KVYFLPItPHYVTQV enzymatic activity, induced 10659854 10 1 0 +Sirt1 SIRT1 Apoptosis; DEACETYLASE; Deacetylase; EC 3.5.1.-; Nuclear receptor co-regulator Q923E4 93759 10|10 B4 mouse S434-p 22568200 LLIVIGSsLKVRPVA SIR2 enzymatic activity, induced transcription, induced; signaling pathway regulation 22195961 1 1 1 cAMP/PKA Pathway; lipid metabolism and fatty acid oxidation +ATP7A ATP7A Apoptosis; Cell development/differentiation; Chaperone; EC 3.6.3.54; Hydrolase; Membrane protein, integral; Membrane protein, multi-pass; Transporter; Transporter, ion channel; Vesicle Q04656 538 Xq21.1 human S1469-p 9768107 ASINSLLsDKRSLNS intracellular localization 19576997 1 7 0 required for post-Golgi exocytic trafficking (Cu -responsive) +CREBBP CBP ACETYLTRANSFERASE; Acetyltransferase; DNA-binding; EC 2.3.1.48; Motility/polarity/chemotaxis; Nuclear receptor co-regulator; Transcription, coactivator/corepressor Q92793 1387 16p13.3 human Y659-p 447690 HLLAEKIyKIQKELE KIX molecular association, regulation transcription, altered Myb(INDUCES); CBP(INDUCES) 12196545 2 1 0 +NPR1 ANPA EC 4.6.1.2; Guanylyl cyclase; KINASE; Kinase, protein; Lyase; Membrane protein, integral; Nucleotide Metabolism - purine; Protein kinase, RGC; Protein kinase, dual-specificity (receptor); Receptor, misc. P16066 4881 1q21.3 human T532-p 447513 RSAGSRLtLSGRGSN activity, induced; enzymatic activity, induced 28416574; 9528788 3 3 1 +Ric8a RIC8A GEF; GEF, misc. NP_001093990 293614 1q41 rat S522-p 3213321 ETMEGQLsSDPDSDP molecular association, regulation G-alpha i1(INDUCES) 29844055 1 5 0 G-alpha subunit guanine nucleotide exchange; G-alpha subunit folding +Nr3c1 GR DNA-binding; Mitochondrial; Nuclear receptor; Transcription factor P06537 14815 18 B3|18 21.09 cM mouse S152-p 3178932 ANLNRSTsRPENPKS GCR neural plasticity 35733193 12 11 6 +PTRH2 PTRH2 EC 3.1.1.29; Hydrolase; Mitochondrial Q9Y3E5 51651 17q23.1 human S5-p 4206801 ___MPSKsLVMEYLA intracellular localization apoptosis, altered; cell adhesion, altered 18703509 1 0 0 associated with anoikis (cell death induced by detachment from the extracellular matrix) +RUNX2 AML3 DNA-binding; Transcription factor Q13950 860 6p21.1 human T198-p 27728402 SGRGKSFtLTITVFT Runt molecular association, regulation transcription, induced DNA(INDUCES) 23389849 1 0 0 induction of MMP3 and MMP9 transcription, invasion of breast cancer cells +Cd226 DNAM-1 Cell adhesion; Immunoglobulin superfamily; Membrane protein, integral Q8K4F0 225825 18|18 E4 mouse Y319-p 454845 DDEKEDIyVNYPTFS receptor internalization, induced; protein degradation; molecular association, regulation; ubiquitination carcinogenesis, induced; cytoskeletal reorganization GRB2(INDUCES); Cbl-b(INDUCES); PIK3R1(INDUCES); VAV1(INDUCES) 26552706; 33053330 6 2 69 +Npr2 ANPB EC 4.6.1.2; Guanylyl cyclase; KINASE; Kinase, protein; Lyase; Membrane protein, integral; Nucleotide Metabolism - purine; Protein kinase, RGC; Protein kinase, dual-specificity (receptor); Receptor, misc. P16067 116564 5q22 rat S513-p 450027 RYHKGAGsRLTLSLR activity, induced 9624142 2 1 0 +Map4 MAP4 Cytoskeletal; Motility/polarity/chemotaxis P27546 17758 9 F2|9 59.83 cM mouse S737-p 476119 ATATARPsTLPARDV intracellular localization cell differentiation, inhibited; apoptosis, induced; cytoskeletal reorganization 30327268; 35902952 3 2 0 +PIK3CD PIK3CD Carbohydrate Metabolism - inositol phosphate; EC 2.7.1.153; KINASE; Kinase, lipid; Motility/polarity/chemotaxis O00329 5293 1p36.22 human Y524-p 454088 RRGSGELyEHEKDLV PI3Ka carcinogenesis, induced; cell growth, induced; apoptosis, inhibited 24213578 1 16 290 +Esrp2 RBM35B RNA-binding Q8K0G8 77411 8|8 D3 mouse K531-ub 52473100 AAQRCHKkMMKERYV RRM_1 carcinogenesis, inhibited; RNA splicing, induced; cell growth, inhibited 26522722 1 0 0 +Kcnb1 Kv2.1 Channel, cation; Channel, ligand-gated; Channel, potassium; Membrane protein, integral; Membrane protein, multi-pass P15387 25736 3q42 rat S15-p 473559 HGSRSTSsLPPEPME activity, inhibited 16917065 2 4 1 +SP3 SP3 C2H2-type zinc finger protein; DNA-binding Q02447 6670 2q31.1 human S73-p 1199100 CSKIGPPsPGDDEEE activity, induced; protein stabilization transcription, induced 17685427 1 19 0 +PDHA1 PDHA1 iso2 Amino Acid Metabolism - valine, leucine and isoleucine biosynthesis; Carbohydrate Metabolism - butanoate; Carbohydrate Metabolism - citrate (TCA) cycle; Carbohydrate Metabolism - glycolysis and gluconeogenesis; Carbohydrate Metabolism - pyruvate; EC 1.2.4.1; Mitochondrial; Oxidoreductase P08559-2 5160 Xp22.12 human S300-p 448258 TYRYHGHsMSDPGVS E1_dh cell growth, induced; transcription, induced 30226812 96 108 675 promotes cell proliferation, induced c-Myc and cyclin 1 expression +SHC3 SHC3 Adaptor/scaffold; Motility/polarity/chemotaxis Q92529 53358 9q22.1 human Y342-p 451258 DGSDHPYyNSIPSKM apoptosis, inhibited 12242309 3 3 8 +NTRK1 TrkA EC 2.7.10.1; KINASE; Kinase, protein; Membrane protein, integral; Oncoprotein; Protein kinase, TK; Protein kinase, tyrosine (receptor) P04629 4914 1q23.1 human Y680-p 447763 RDIYSTDyYRVGGRT PK_Tyr_Ser-Thr receptor internalization, altered; enzymatic activity, induced 15601748 14 3 10 +IRF3 IRF3 DNA-binding; Transcription factor Q14653 3661 19q13.33 human S398-p 449029 VDLHISNsHPLSLTS activity, induced; protein degradation; molecular association, regulation; intracellular localization autophagy, induced; transcription, induced; transcription, altered CALCOCO2(INDUCES); IRF3(INDUCES); CBP(INDUCES) 14703513; 18272581; 19153595; 25070846; 27992402; 35948267; 37330913; 9566918 10 2 0 GPR108 and Smurf1 mediated degradation requires NDP52; NDP52-dependent autophagic degradation of phosphorylated IRF3; GPR108 interacts with Smurf1, followed by the recruitment of IRF3 during viral infection +HSP90AA1 HSP90A Chaperone; Heat shock protein P07900 3320 14q32.31 human T425-p 30957300 KKCLELFtELAEDKE HSP90 molecular association, regulation; protein conformation PKCG(DISRUPTS) 24117238 1 0 0 affects its ATP-binding affinity and ATPase activity,; PKC? phosphorylation of chaperone Hsp90? triggers its own release from the Hsp90? chaperone machinery. +BST2 BST2 Cell development/differentiation; Membrane protein, GPI anchor; Membrane protein, integral Q10589 684 19p13.11 human K18-ub 14512105 VPMEDGDkRCKLLLG protein degradation; intracellular localization 20419159 1 1 0 inhibits BST2-mediated restriction on the release of KSHV and HIV-1 viral particles +Notch1 Notch 1 Membrane protein, integral; Motility/polarity/chemotaxis; Oncoprotein; Receptor, misc.; Transcription factor Q01705 18128 2 A3|2 18.91 cM mouse K1770-ac 18899512 FKVSEASkKKRREPL protein stabilization; ubiquitination 21499261 1 1 0 +Mef2d MEF2D DNA-binding; Transcription factor Q63943 17261 3 F1|3 38.78 cM mouse K432-ac 458892 THPHISIkSEPVSPS cell differentiation, induced; transcription, induced 16166628 1 0 0 +RUNX1 AML1 iso8 DNA-binding; Oncoprotein; Transcription factor Q01196-8 861 21q22.12 human S424-p 1308915 SMVGGERsPPRILPP RunxI activity, induced; molecular association, regulation cell growth, induced; transcription, induced; cell growth, altered HDAC1(DISRUPTS); HDAC3(DISRUPTS) 18003885; 21059642 2 0 2 increases RUNX1 trans-activation; increases marrow progenitor proliferation +NEDD4L NEDD4L EC 6.3.2.-; EC 6.3.2.19; Ligase; UBIQUITIN LIGASE; Ubiquitin conjugating system; Ubiquitin ligase Q96PU5 23327 18q21.31 human S448-p 453440 IRRPRSLsSPTVTLS activity, induced; protein stabilization; molecular association, regulation; ubiquitination; protein conformation; phosphorylation carcinogenesis, inhibited; signaling pathway regulation 14-3-3 sigma(INDUCES); 14-3-3 zeta(INDUCES); 14-3-3 epsilon(INDUCES); SLC22A11(DISRUPTS); 14-3-3 eta(INDUCES); NKCC2(DISRUPTS); SMAD3(DISRUPTS); 14-3-3 beta(INDUCES); ENaC-alpha(DISRUPTS); 14-3-3 gamma(INDUCES); ENaC-beta(DISRUPTS); ENaC-alpha(INDUCES) 11742982; 15328345; 15677482; 16716084; 19917253; 21852580; 24657276; 30453017; 34294877; 37494179 16 64 53 inhibits NCC ubiquitination, SGK1-Nedd4-2 Pathway; induces ubiquitination and degradation of HIF1A +NKX3-1 NKX3-1 DNA-binding; Transcription factor; Tumor suppressor Q99801 4824 8p21.2 human S195-p 4913200 LGDLEKHsSLPALKE protein degradation; ubiquitination 18757402 2 1 0 +EEF2K EEF2K EC 2.7.11.20; KINASE; Kinase, protein; Protein kinase, Ser/Thr (non-receptor); Protein kinase, atypical; Translation O00418 29904 16p12.2 human S78-p 450687 SSGSPANsFHFKEAW molecular association, regulation; enzymatic activity, inhibited; enzymatic activity, induced cell growth, induced; autophagy, inhibited Calmodulin(DISRUPTS) 15024086; 21112387; 22216903; 23182879 7 14 0 +AR AR DNA-binding; Nuclear receptor; Transcription factor P10275 367 Xq12 human K631-ac 458906 GMTLGARkLKKLGNL activity, induced; protein stabilization; molecular association, regulation; intracellular localization; phosphorylation carcinogenesis, induced; carcinogenesis, inhibited; apoptosis, induced; transcription, induced; transcription, altered; signaling pathway regulation; cell growth, induced; apoptosis, inhibited HDAC1(DISRUPTS); N-CoR1(DISRUPTS); p300(INDUCES); SMAD3(DISRUPTS) DNA(INDUCES) 10779504; 11971970; 11994312; 14612401; 15123687; 16860317; 17483368; 18022799; 22131404; 28511652 11 1 0 +GMNN Geminin Cell cycle regulation; Motility/polarity/chemotaxis O75496 51053 6p22.3 human S202-p 475944 AEGTVSSsTDAKPCI apoptosis, altered 17261582 1 0 0 regulates geminin cleavage by caspase-3 +PAK1 PAK1 EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, STE; Protein kinase, Ser/Thr (non-receptor) Q13153 5058 11q13.5-q14.1 human Y153-p 463955 TDKSAEDyNSSNALN protein stabilization; molecular association, regulation; intracellular localization; enzymatic activity, induced carcinogenesis, induced; apoptosis, altered; cell motility, induced; transcription, induced; signaling pathway regulation; cell growth, induced; cell motility, altered; cytoskeletal reorganization GIT1(INDUCES); ARHGEF7(INDUCES); Snail1(INDUCES) 17726028; 21566085; 21719533; 23340249; 25125660; 25466889; 26944939; 27003261; 27542844 9 1 21 PAK1 phosphorylation stimulates PRL-induced tumor metastasis +SMAD3 SMAD3 DNA-binding; Nuclear receptor co-regulator; Transcription factor P84022 4088 15q22.33 human S416-p 3193766 KVLTQMGsPSIRCSS intracellular localization 18760948 1 3 0 nuclear translocation +GSK3B GSK3B EC 2.7.11.1; EC 2.7.11.26; KINASE; Kinase, protein; Protein kinase, CMGC; Protein kinase, Ser/Thr (non-receptor) P49841 2932 3q13.33 human T43-p 456221 KVTTVVAtPGQGPDR enzymatic activity, induced 18451303 2 2 0 +Kcnd3 Kv4.3 Channel, potassium; Membrane protein, integral; Membrane protein, multi-pass Q62897 65195 2q34 rat S535-p 3681504 YPSTRSPsLSSHSGL DUF3399 activity, inhibited 18599872 1 0 0 +PIK3R6 PIK3R6 Q5UE93 146850 17p13.1 human T607-p 10799542 SHRPREVtVSLRATG PI3K_1B_p101 molecular association, regulation; intracellular localization; enzymatic activity, inhibited; protein conformation carcinogenesis, inhibited; cell motility, inhibited PIK3CG(INDUCES) 25753393 1 0 1 +Kcnma1 KCNMA1 Channel, potassium; Endoplasmic reticulum; Membrane protein, integral; Membrane protein, multi-pass Q08460 16531 14|14 A3 mouse Y831-p 11502400 VFVGSIEyLKREWET activity, induced 19887442 1 0 0 +SUFU SUFU Adaptor/scaffold; Transcription, coactivator/corepressor; Tumor suppressor Q9UMX1 51684 10q24.32 human S352-p 20652725 DSLESDSsTAIIPHE SUFU_C molecular association, regulation FBXL17(DISRUPTS) 27234298 1 1 1 +ITCH ITCH EC 6.3.2.-; EC 6.3.2.19; Ligase; UBIQUITIN LIGASE; Ubiquitin conjugating system; Ubiquitin ligase Q96J02 83737 20q11.22 human S257-p 83110609 PSRPPRPsRPPPPTP ubiquitination; intracellular localization carcinogenesis, induced; signaling pathway regulation 30517763 1 2 0 ; H1.2 ubiquitination; translocation to nucleus +Bid BID Apoptosis; Mitochondrial P70444 12122 6 F1|6 57.02 cM mouse S66-p 14570494 DGSQASRsFNQGRIE BID cell cycle regulation; apoptosis, induced 24767991 2 5 0 +RNF157 RNF157 UBIQUITIN LIGASE; Ubiquitin conjugating system; Ubiquitin ligase Q96PX1 114804 17q25.1 human S660-p 4334560 NAQRRRLsSSSLEDS protein degradation; molecular association, regulation; ubiquitination CDH1(INDUCES) 28655764 1 1 3 +Sdc2 syndecan-2 Cell adhesion; Cell surface; Membrane protein, integral; Motility/polarity/chemotaxis P34900 25615 7q22 rat Y191-p 448376 RKPSSAAyQKAPTKE Syndecan molecular association, regulation cytoskeletal reorganization EphB2(INDUCES) 11580899 1 5 6 +SREBF1 SREBP-1 DNA-binding; Membrane protein, integral; Membrane protein, multi-pass; Transcription factor P36956 6720 17p11.2 human R321-m2 53350800 APASAQSrGEKRTAH protein stabilization; molecular association, regulation cell growth, induced; transcription, induced FBXW7(DISRUPTS) 26759235 1 1 0 PRMT5 knockdown caused faster degradation, PRMT5-induced methylation prevented phosphorylation of SREBP1A on S430 +Aqp2 AQP2 Channel, misc.; Membrane protein, integral; Membrane protein, multi-pass; Transporter; Transporter, aquaporin family P56402 11827 15 F1|15 56.13 cM mouse K270-ub 999601 QSLPRGSkA______ protein stabilization; ubiquitination 24876223; 28052875 6 0 0 +Itpr1 IP3R1 Channel, calcium; Channel, ligand-gated; Membrane protein, integral; Membrane protein, multi-pass P11881 16438 6 E1|6 49.74 cM mouse S436-p 469626 AFAIVPVsPAEVRDL activity, induced; molecular association, regulation; activity, inhibited 16925983; 16979595; 26259730 3 2 0 enhance Ca2+ oscillations, enhance the sensitivity of IP3R1; inhibits binding to IP3 in vitro and IP3R1-mediated intracellular calcium release in vivo; reduces intracellular calcium release in response to anti-IgM stimulation +HSF1 HSF1 DNA-binding; Transcription factor Q00613 3297 8q24.3 human K208-ac 31953302 RILGVKRkIPLMLND protein stabilization; protein conformation 24581496 1 1 0 +MITF MITF DNA-binding; Oncoprotein; Transcription factor O75030 4286 3p13 human Y360-p 50783666 ILKASVDyIRKLQRE HLH protein degradation; molecular association, regulation autophagy, induced SQSTM1(INDUCES) 35092699 1 1 0 +EGFR EGFR EC 2.7.10.1; KINASE; Kinase, protein; Membrane protein, integral; Oncoprotein; Protein kinase, TK; Protein kinase, tyrosine (receptor) P00533 1956 7p11.2 human K37-sm 49199200 VCQGTSNkLTQLGTF transcription, induced 26244656 1 1 0 +Pbk PBK Cancer Testis Antigen (CTA); EC 2.7.12.2; KINASE; Kinase, protein; Protein kinase, Other; Protein kinase, Ser/Thr (non-receptor); Protein kinase, dual-specificity (non-receptor) Q9JJ78 52033 14 D1|14 34.36 cM mouse T9-p 451735 EGINNFKtPNKSEKR phosphorylation; enzymatic activity, induced cell cycle regulation; cell growth, induced; apoptosis, inhibited; signaling pathway regulation 16291951; 35678915 6 12 2 activated in the mitotic cells; induces AKT phosphorylation and signaling +Stk39 STLK3 EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, STE; Protein kinase, Ser/Thr (non-receptor) Q9Z1W9 53416 2|2 C1.3 mouse T243-p 456505 TRNKVRKtFVGTPCW Pkinase enzymatic activity, induced cell cycle regulation; cell motility, induced; cell growth, induced; cell adhesion, inhibited 16382158; 20463172; 21486947; 36662229 12 5 51 +GSK3B GSK3B EC 2.7.11.1; EC 2.7.11.26; KINASE; Kinase, protein; Protein kinase, CMGC; Protein kinase, Ser/Thr (non-receptor) P49841 2932 3q13.33 human K205-ac 27738300 LCDFGSAkQLVRGEP Pkinase intracellular localization; phosphorylation carcinogenesis, induced; cell growth, induced; apoptosis, inhibited; transcription, inhibited; signaling pathway regulation 25915842 2 0 0 induces phosphorylation of itself, inhibits transcription and localization of Bax, regulates Bax signaling +SNCA SNCA Adaptor/scaffold P37840 6622 4q22.1 human T75-gl 1498941802 GAVVTGVtAVAQKTV Synuclein protein stabilization 30651314 0 1 0 inhibits the aggregation of alpha-synuclein but can also alter the structure of a-synuclein aggregates in site specific ways, inhibit a-Synuclein toxicity +KCNMA1 KCNMA1 Channel, potassium; Endoplasmic reticulum; Membrane protein, integral; Membrane protein, multi-pass Q8AYS8 374065 chicken T989-p 485931 ALRGGYStPQTLANR intracellular localization 22094329 1 5 3 +SGO1 SGO1 Cell cycle regulation Q5FBB7 151648 3p24.3 human S14-p 486241 LKKSFQDsLEDIKKR chromatin organization, altered 17621308 1 0 0 required for proper association between the kinetochore and spindle microtubules +WIPI2 WIPI2 Autophagy Q9Y4P8 26100 7p22.1 human S413-p 3217428 KGTYVPSsPTRLAYT autophagy, inhibited 36476874 1 26 5 +LRRK2 LRRK2 EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, Ser/Thr (non-receptor); Protein kinase, TKL Q5S007 120892 12q12 human S935-p 4725898 NLQRHSNsLGPIFDH protein stabilization; molecular association, regulation; ubiquitination; enzymatic activity, inhibited; intracellular localization; phosphorylation 14-3-3 beta(INDUCES); 14-3-3 sigma(INDUCES); 14-3-3 theta(INDUCES); 14-3-3 zeta(INDUCES); 14-3-3 epsilon(INDUCES); 14-3-3 gamma(INDUCES); 14-3-3 eta(INDUCES) 20642453; 20659021; 21378983; 22004453; 24942733; 25009464; 32317922; 32601174; 34144124; 35266954 43 17 2 +Ppp1r12a MYPT1 Motility/polarity/chemotaxis; PHOSPHATASE; Protein phosphatase, regulatory subunit Q10728 116670 7q21 rat S854-p 451999 RPREKRRsTGVSFWT intracellular localization 10579722 9 2 13 +BACE1 BACE EC 3.4.23.46; Membrane protein, integral; Protease P56817 23621 11q23.3 human K299-ac 478253 TTNLRLPkKVFEAAV Asp protein stabilization; intracellular localization 17425515 1 1 0 regulates translocation through secretory pathway +RPA1 RPA1 DNA-binding P27694 6117 17p13.3 human K577-sm 1872852102 FIFRVRVkVETYNDE Rep_fac-A_C DNA repair, induced 22661229 1 0 0 +DGCR8 DGCR8 Nucleolus; RNA processing; RNA-binding Q8WYQ5 54487 22q11.21 human S92-p 3208086 LLIDPNCsGHSPRTA protein stabilization 24239349 0 13 0 +DAPK1 DAPK1 Apoptosis; Autophagy; EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, CAMK; Protein kinase, Ser/Thr (non-receptor) P53355 1612 9q21.33 human S289-p 457379 QALSRKAsAVNMEKF activity, inhibited; enzymatic activity, induced apoptosis, altered; signaling pathway regulation 16213824; 31116076 2 8 24 Phosphorylation of site suppresses apoptotic activity of DAPK; MAPK-DAPK1 signaling pathway +THRA TR-alpha DNA-binding; Nuclear receptor; Transcription factor NP_990644 396251 chicken K134-ac 10769108 SKRVAKRkLIEENRE molecular association, regulation carcinogenesis, inhibited; transcription, altered SMRT(DISRUPTS); ACTR1A(INDUCES) DNA(INDUCES) 19819978 1 0 0 induces transactivation and transrepression of transcription +Nfya NFYA DNA-binding; Transcription factor P23708 18044 17 C|17 23.99 cM mouse K289-ub 4664702 AKLEAEGkIPKERRK CBFB_NFYA protein degradation cell growth, inhibited; transcription, inhibited 18815279 1 0 0 +HIPK2 HIPK2 EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, CMGC; Protein kinase, Ser/Thr (non-receptor) Q9H2X6 28996 7q34 human K552-ub 3059902 FQNMEICkRRVNMYD protein degradation 18536714 1 2 0 +EEF1A2 EEF1A2 Translation; Translation elongation Q05639 1917 20q13.33 human S21-p 5434143 GHVDSGKsTTTGHLI GTP_EFTU protein degradation; ubiquitination apoptosis, induced 22378069 1 4 5 +CD247 CD3Z Membrane protein, integral; Receptor, misc. P20963 919 1q24.2 human Y72-p 448936 QQGQNQLyNELNLGR ITAM phosphorylation 16919488 3 12 369 required for ERK phosphorylation after SDF1a treatment +Eif4e EIF4E Translation; Translation initiation P63073 13684 3 G3|3 64.3 cM mouse T210-p 450199 TATKSGStTKNRFVV molecular association, regulation; protein conformation eIF4G(INDUCES) 9878069 3 2 0 +Mos MOS EC 2.7.11.1; KINASE; Kinase, protein; Oncoprotein; Protein kinase, Other; Protein kinase, Ser/Thr (non-receptor) P00536 17451 4 A1|4 2.16 cM mouse S16-p 466945 RYLPRELsPSVDSRS protein stabilization; molecular association, regulation cell growth, altered 10439036 2 1 0 +SERINC5 SERINC5 Membrane protein, integral; Membrane protein, multi-pass Q86VE9 256987 5q14.1 human K130-ub 1883494503 HNGFWFFkLLLLGAM Serinc intracellular localization 35474067 1 1 0 downregulation by HIV-1 Nef, required for SERINC5 anti-HIV-1 activity +PITX1 PITX1 Cell development/differentiation; DNA-binding; Transcription factor P78337 5307 5q31.1 human Y160-p 54204601 LDLCKGGyVPQFSGL protein degradation; protein stabilization transcription, inhibited 26840794; 27752061 2 0 0 +TAB3 TAB3 Adaptor/scaffold Q8N5C8 257397 Xp21.2 human T404-p 1295506 HSLYTATtPPSSSPS O-GlcNAc glycosylation 27009840 2 6 4 increased TAB3 T404 phosphoryaltion +Cftr CFTR Channel, chloride; EC 3.6.3.49; Hydrolase; Membrane protein, integral; Membrane protein, multi-pass; Transporter; Transporter, ABC family P26361 12638 6 A2|6 8.1 cM mouse S737-p 3116903 RLSLVPDsEQGEAAL CFTR_R activity, induced 35353541 1 2 0 +CTNNB1 CTNNB1 Actin-binding; Cell adhesion; Motility/polarity/chemotaxis; Nuclear receptor co-regulator; Oncoprotein; Transcription factor P35222 1499 3p22.1 human Y86-p 447584 VADIDGQyAMTRAQR protein stabilization; molecular association, regulation; ubiquitination; intracellular localization carcinogenesis, induced; cell growth, induced; transcription, induced; transcription, altered; cell growth, altered TCF4(INDUCES); TBN(INDUCES); axin 1(DISRUPTS) 17318191; 20840866; 35697802 9 1 22 inhibits ubiquitination +Ndel1 NDEL1 Microtubule-binding; Protease Q9ERR1 83431 11|11 B3 mouse S198-p 474508 TRKSAPSsPTLDCEK NUDE_C activity, induced; intracellular localization cell motility, altered 18331715 4 25 0 Cdc42 activation +ARHGEF7 ARHGEF7 GEF; GEF, Rac/Rho; Motility/polarity/chemotaxis Q14155 8874 13q34 human Y620-p 3753309 PAPLTPAyHTLPHPS activity, induced; molecular association, regulation cell growth, altered EGFR(INDUCES); CDC42 iso1(INDUCES); Cbl-b(INDUCES) 16892055 3 0 4 GEF activity for Cdc42 +Eif3f eIF3-epsilon EC 3.4.19.12; Translation; Translation initiation Q9DCH4 66085 7|7 E3 mouse K301-ub 7388008 AEDVLSGkVSADNTV MitMem_reg protein degradation 19073596 1 1 0 regulates skeletal muscle atrophy +KCNJ4 HIR Channel, potassium; Membrane protein, integral; Membrane protein, multi-pass P48050 3761 22q13.1 human Y234-p 19003800 YMTQEGEyLPLDQRD IRK_C activity, induced 21486282 1 0 0 increased channel current +CTNNB1 CTNNB1 Actin-binding; Cell adhesion; Motility/polarity/chemotaxis; Nuclear receptor co-regulator; Oncoprotein; Transcription factor XP_008258482 100125985 rabbit S552-p 472273 QDTQRRTsMGGTQQQ intracellular localization cell differentiation, induced 34094857 44 64 9 +GGA3 GGA3 Adaptor/scaffold; Vesicle Q9NZ52 23163 17q25.1 human S368-p 456842 QASGPPRsRSSSQAE molecular association, regulation; protein conformation 16135791 1 0 0 phosphorylation of this residue regulates the association of GGA3 with membranes +ABL2 Arg EC 2.7.10.2; KINASE; Kinase, protein; Oncoprotein; Protein kinase, TK; Protein kinase, tyrosine (non-receptor) P42684 27 1q25.2 human Y116-p 2226537 PNLFVALyDFVASGD SH3_1 enzymatic activity, induced 34144039 1 2 9 +Tbc1d4 AS160 GAP; GAP, Rab Q8BYJ6 210789 14|14 E2.3 mouse S764-p 3175636 SSTCSNEsLNAGGTP phosphorylation 33872597 1 18 71 affects phosphorylation of other sites by AKT +Cd79a Ig-alpha Immunoglobulin superfamily; Membrane protein, integral P11911 12518 7 A3|7 13.49 cM mouse S191-p 17342617 GLNLDDCsMYEDISR ITAM phosphorylation signaling pathway regulation 21841126 1 0 4 modulates T cell independent type II Ag response; phosphorylation at this site inhibits in vivo phosphorylation of tyrosine in Ig alpha +SDHA SDHA Carbohydrate Metabolism - citrate (TCA) cycle; EC 1.3.5.1; Energy Metabolism - oxidative phosphorylation; Mitochondrial; Oxidoreductase; Tumor suppressor P31040 6389 5p15.33 human Y215-p 25682901 SLRYDTSyFVEYFAL FAD_binding_2 apoptosis, inhibited 22823520 2 0 0 +Rbck1 RBCK1 EC 6.3.2.-; Ligase; UBIQUITIN LIGASE; Ubiquitin conjugating system; Ubiquitin ligase Q62921 rat T161-p 2103604 DLGFKDLtLQPRGPL protein stabilization 18303026 1 0 0 inhibits self-ubiquitination of RBCK1 in vitro +Myrf MRF DNA-binding; Membrane protein, integral Q3UR85 225908 19|19 A mouse S138-p 20804934 APGTLPDsPPDSGSE protein degradation; ubiquitination 29472293 1 1 0 +Gria2 GluR2 Channel, calcium; Channel, ligand-gated; Membrane protein, integral; Membrane protein, multi-pass P19491 29627 2q33 rat K870-ub 27191129 SQNFATYkEGYNVYG protein degradation; intracellular localization 25660027 2 1 0 +STING1 STING Apoptosis; Endoplasmic reticulum; Membrane protein, integral; Membrane protein, multi-pass; Mitochondrial Q86WV6 340061 5q31.2 human K150-ub 7388017 EISAVCEkGNFNVAH TMEM173 protein degradation; intracellular localization transcription, inhibited; signaling pathway regulation 19285439 2 0 0 regulation of virus-triggered signaling and antiviral response via IRF3 activation +Ksr2 KSR2 EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, Ser/Thr (non-receptor); Protein kinase, TKL Q3UVC0 333050 5|5 F mouse S314-p 4721664 TALHRSKsHEFQLGN molecular association, regulation; intracellular localization 14-3-3 beta(INDUCES) 19560418 1 5 0 +Scn2a SCN2A Channel, sodium; Membrane protein, integral; Membrane protein, multi-pass P04775 24766 3q21 rat S573-p 451193 LFSPRRNsRASLFNF Na_trans_cytopl activity, inhibited 12359152; 9236220; 9295379 4 2 1 reduces peak Na(+) current. +Stk11 LKB1 Autophagy; EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, CAMK; Protein kinase, Ser/Thr (non-receptor); Tumor suppressor Q9WTK7 20869 10|10 C1 mouse Y261-p 13258700 PFEGDNIyKLFENIG Pkinase molecular association, regulation; intracellular localization; phosphorylation cell differentiation, induced; signaling pathway regulation PLCG1(INDUCES); LAT(INDUCES); Fyn(INDUCES) 20142099; 21487392; 24586906 3 0 0 TCR signaling, recruitment of PLCG1 to the LAT signalosome; mutation of this site increses AMPK phosphorylation; LKB1 cytosolic localization, induced AMPK phosphorylation +TUBA1A TUBA1A Cytoskeletal; Motility/polarity/chemotaxis Q71U36 7846 12q13.12 human K304-sm 1881132901 EPANQMVkCDPRHGK sumoylation cytoskeletal reorganization 33394042 1 0 0 promotes microtubule catastrophe, attenuates MT polymerization, facilitates neurite extension +PHOX2A PHOX2A DNA-binding; Transcription factor O14813 401 11q13.4 human S202-p 9400303 PPAPGLAsPRLSPSP phosphorylation 19564421 1 1 0 regulates phosphorylation of PHOX2A S153 +DOCK8 DOCK8 GEF; GEF, misc.; Motility/polarity/chemotaxis Q8NF50 81704 9p24.3 human S2082-p 3929310 VESQKRDsFHRSSFR molecular association, regulation cell motility, induced LRCH1(DISRUPTS) 28028151 1 5 7 +GPR26 GPR26 GPCR, family 1; Membrane protein, integral; Membrane protein, multi-pass; Receptor, GPCR Q8NDV2 2849 10q26.13 human K286-ub 1881186503 SKCLAYSkAASDPFV protein degradation; ubiquitination carcinogenesis, inhibited; cell growth, inhibited 33577134 1 0 0 K286R inhibited ubiquitylation, increased protein expression and induced an antitumor function in liver cancer cells. +Ipmk IPMK Carbohydrate Metabolism - inositol phosphate; EC 2.7.1.151; Kinase, other; Motility/polarity/chemotaxis Q99NI4 171458 20p11 rat Y174-p 22826100 YHLHSDSyETQNQHY IPK molecular association, regulation AMPKA2(INDUCES) 22203993 1 0 0 +CKAP4 CKAP4 Endoplasmic reticulum; Membrane protein, integral Q07065 10970 12q23.3 human S19-p 455355 GHGAASPsEKGAHPS molecular association, regulation; intracellular localization; palmitoylation neural plasticity; cell growth, inhibited; cytoskeletal reorganization; transcription, altered; signaling pathway regulation DNA(INDUCES) 15703217; 22265418; 22536245 3 1 0 +UHRF1 UHRF1 DNA-binding; EC 6.3.2.-; EC 6.3.2.19; Ligase; Transcription factor; UBIQUITIN LIGASE; Ubiquitin conjugating system; Ubiquitin ligase Q96T88 29128 19p13.3 human K490-ac 1875274100 GRDLSGNkRTAEQSC SAD_SRA molecular association, regulation cell cycle regulation; chromatin organization, altered DNA(DISRUPTS) 32726623 1 1 0 inhibits chromatin association; attenuates binding afinity to hemi-methylated DNA; disrupts the inheritance of global DNA methylation patterns +DUSP1 DUSP1 EC 3.1.3.16; EC 3.1.3.48; Motility/polarity/chemotaxis; PHOSPHATASE; Protein phosphatase, dual-specificity P28562 1843 5q35.1 human S359-p 448660 SALSYLQsPITTSPS protein stabilization 10617468; 25204653 4 0 0 +CTNND1 CTNND1 Actin-binding; Adaptor/scaffold; Cell adhesion; G protein regulator, misc.; Motility/polarity/chemotaxis O60716 1500 11q12.1 human Y96-p 449495 QDHSHLLySTIPRMQ intracellular localization 26302406 4 35 735 Y228 and Y96 basolateral localization, T310 was both apically and basoleterally localized +CILK1 ICK EC 2.7.11.22; KINASE; Kinase, protein; Protein kinase, CMGC; Protein kinase, Ser/Thr (non-receptor) Q9UPZ9 22858 6p12.1 human T157-p 456051 IRSKPPYtDYVSTRW Pkinase intracellular localization cytoskeletal reorganization 32732286 3 21 86 induces IFT accumulation at cilia tips +Rbbp8 CtIP EC 3.1.-.-; Transcription, coactivator/corepressor Q80YR6 225182 18|18 A1 mouse T843-p 7113805 FRYIPPNtPENFWEV SAE2 DNA repair, induced; cell growth, inhibited; cell growth, induced; transcription, inhibited 31097467; 36640339 7 1 1 +Plcg2 PLCG2 Carbohydrate Metabolism - inositol phosphate; EC 3.1.4.11; Motility/polarity/chemotaxis; Phospholipase P24135 29337 19q12 rat Y753-p 447940 ERDINSLyDVSRMYV enzymatic activity, induced 11507089 10 11 270 +Sh3rf1 SH3RF1 Adaptor/scaffold; EC 6.3.2.-; EC 6.3.2.19; Ligase; UBIQUITIN LIGASE; Ubiquitin conjugating system; Ubiquitin ligase Q69ZI1 59009 8|8 B3.1 mouse S304-p 482847 KNTRKRHsFTSLTMA cell cycle regulation; cell growth, inhibited; cell differentiation, induced; signaling pathway regulation 30361695 2 18 22 Suppression of JNK signaling +TERF1 TRF1 DNA-binding P54274 7013 8q21.11 human S219-p 448475 SKLLMIIsQKDTFHS TRF apoptosis, inhibited 11375976 1 0 0 +KLF1 KLF1 C2H2-type zinc finger protein; DNA-binding; Transcription factor Q13351 10661 19p13.13 human K274-ac 460630 GRRSWARkRQAAHTC activity, induced; molecular association, regulation transcription, induced 11259590; 9707565 3 0 0 +CHAT CHAT iso3 ACETYLTRANSFERASE; Acetyltransferase; EC 2.3.1.6; Lipid Metabolism - glycerophospholipid P28329-3 1103 10q11.23 human S440-p 449057 VPTYESAsIRRFQEG Carn_acyltransf activity, induced; enzymatic activity, induced 12486117; 15381704 2 1 0 +DKC1 dyskerin EC 5.4.99.-; Isomerase; Lyase; Nucleolus; RNA processing; RNA-binding O60832 1736 Xq28 human K467-sm 1881186501 PAAPQLIkKEKKKSK intracellular localization NOLA1(INDUCES) 33526451 1 0 0 disrupts subnuclear localization +KAT5 Tip60 ACETYLTRANSFERASE; Acetyltransferase; EC 2.3.1.48; Nuclear receptor co-regulator; Nucleolus Q92993 10524 11q13.1 human K430-sm 1968600 LEILMGLkSESGERP MOZ_SAS intracellular localization; enzymatic activity, induced DNA repair, induced 17704809 1 0 0 +MFN2 MFN2 Cell cycle regulation; Cytoskeletal; EC 3.6.5.-; Hydrolase; Membrane protein, integral; Membrane protein, multi-pass; Mitochondrial O95140 9927 1p36.22 human S378-p 1877509600 AVRLIMDsLHMAARE autophagy, induced 35646911 1 0 0 miophagy +MYC Myc DNA-binding; Nucleolus; Oncoprotein; Transcription factor P01106 4609 8q24.21 human T259-p 1876391100 PLVLHEEtPPTTSSD Myc_N protein degradation; molecular association, regulation; ubiquitination FBXW7(INDUCES) 35089787 1 0 0 +DLD DLD Amino Acid Metabolism - glycine, serine and threonine; Amino Acid Metabolism - valine, leucine and isoleucine degradation; Carbohydrate Metabolism - citrate (TCA) cycle; Carbohydrate Metabolism - glycolysis and gluconeogenesis; Carbohydrate Metabolism - pyruvate; EC 1.8.1.4; Mitochondrial; Oxidoreductase P09622 1738 7q31.1 human T135-p 18262251 STAVKALtGGIAHLF Pyr_redox_2 enzymatic activity, induced 29358703 1 3 0 +BCL3 Bcl-3 Apoptosis; Nuclear receptor co-regulator; Oncoprotein; Transcription regulation P20749 602 19q13.32 human K34-ub 3627523 GAALPLRkRPLRAPS protein degradation transcription, altered 15469820 1 0 0 +SREBF1 SREBP-1 iso3 DNA-binding; Membrane protein, integral; Membrane protein, multi-pass; Transcription factor P36956-3 6720 17p11.2 human S372-p 4934079 TAVHKSKsLKDLVSA protein stabilization; intracellular localization; activity, inhibited transcription, induced; transcription, inhibited 21459323; 30733434; 33675805 3 1 6 inhibits proteolytic processing; inhibits lipogenesis +KRAS KRas G protein; G protein, monomeric; G protein, monomeric, Ras; Motility/polarity/chemotaxis; Oncoprotein P01116 3845 12p12.1 human K147-ub 15391092 PFIETSAkTRQRVED Ras molecular association, regulation; enzymatic activity, induced RAF1(DISRUPTS); RASA1(DISRUPTS); RALGDS(DISRUPTS); PIK3CG(DISRUPTS) 24030601; 29185849 4 6 3 Mant-?uorescence binding assay, enhanced (40-fold) binding to the CRAF RBD when bound to GDP +XIAP XIAP Apoptosis; EC 6.3.2.-; Ligase; UBIQUITIN LIGASE; Ubiquitin conjugating system; Ubiquitin ligase P98170 331 Xq25 human K328-ub 22254948 AKWYPGCkYLLEQKG BIR protein degradation 22072751 1 2 0 +POU5F1 Oct4 DNA-binding; Transcription factor Q01860 5460 6p21.33 human K156-ac 57951802 FAKLLKQkRITLGYT Pou protein stabilization; molecular association, regulation transcription, induced SOX2(INDUCES) 27369080 1 1 0 +BCL2L11 BIM Apoptosis O43521 10018 2q13 human S94-p 4698178 SLLSRSSsGYFSFDT protein degradation; molecular association, regulation; ubiquitination BTRC(INDUCES) 23912711 1 6 0 +Wnk4 WNK4 EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, Other; Protein kinase, Ser/Thr (non-receptor) Q80UE6 69847 11|11 D mouse K1137-ub 40323303 ALQTLQKkEIEDLYS protein degradation 23576762 1 1 0 regulates electrolyte homeostasis and involved in Pseudohypoaldosteronism type II (PHAII) pathogenesis +Pdx1 PDX1 DNA-binding; Transcription factor P52946 18609 5 G3|5 86.84 cM mouse S66-p 458402 QGSPPDIsPYEVPPL protein degradation 16407209 3 0 0 +TTK TTK Cancer Testis Antigen (CTA); EC 2.7.12.1; KINASE; Kinase, protein; Protein kinase, Other; Protein kinase, dual-specificity (non-receptor) P33981 7272 6q14.1 human S821-p 467281 GQLVGLNsPNSILKA intracellular localization 18787396; 18923149; 27631493 9 31 5 regulates kinetochore localization of TTK; kinetochore localization +SIRT6 SIRT6 DEACETYLASE; DEUBIQUITINASE; Deacetylase; EC 2.4.2.31; EC 3.5.1.-; Transferase Q8N6T7 51548 19p13.3 human S338-p 7916000 PKRERPTsPAPHRPP protein degradation; molecular association, regulation; intracellular localization; phosphorylation DNA repair, induced; carcinogenesis, induced; cell growth, induced; apoptosis, inhibited NUP88(INDUCES); NUP155(INDUCES); NUP85(INDUCES); NUP214(INDUCES); NUP35(INDUCES) 24163442; 25074979; 34359939 3 7 23 regulates phosphorylation of ATM and CHK2, confers resistance to doxorubicin +MLH1 MLH1 Cell cycle regulation; DNA repair, damage; Tumor suppressor P40692 4292 3p22.2 human K361-ub 1878089101 GPSGEMVkSTTSLTS molecular association, regulation MSH2(INDUCES); MSH6(INDUCES) 30770470 1 1 0 +PRKDC DNAPK DNA repair, damage; EC 2.7.11.1; KINASE; Kinase, protein; Nucleolus; Protein kinase, Ser/Thr (non-receptor); Protein kinase, atypical P78527 5591 8q11.21 human T3950-p 473573 GHAFGSAtQFLPVPE PI3_PI4_kinase intracellular localization; enzymatic activity, inhibited cell cycle regulation 17158925; 24844881 2 1 0 +CTTN Cortactin Actin-binding; Cytoskeletal; Motility/polarity/chemotaxis Q14247 2017 11q13.3 human Y446-p 448776 GTEPEPVySMEAADY protein degradation; molecular association, regulation; intracellular localization cell growth, induced; apoptosis, inhibited PTP1B(INDUCES) 18387954; 27363897 3 36 867 p21Cip1 degradation and nuclear export, HASMC proliferation; potentiates apoptosis during prolonged hyperosmotic stress +SLC6A12 SLC6A12 Membrane protein, integral; Membrane protein, multi-pass; Transporter; Transporter, SLC family P27799 404013 dog T40-p 33673901 VKDRGQWtNKMEFVL SNF activity, induced; intracellular localization 24829506 1 0 0 important for trafficking and insertion of SLC6A12 in the plasma membrane +Ncoa1 SRC-1 ACETYLTRANSFERASE; Acetyltransferase; DNA-binding; EC 2.3.1.48; Nuclear receptor co-regulator; Oncoprotein; Transcription, coactivator/corepressor P70365 17977 12|12 A1.1 mouse S1271-p 396518803 MPVPPPQsSLLQQTP DUF1518 molecular association, regulation cell differentiation, induced; transcription, induced RORC(INDUCES) 29282318 1 1 0 +Cebpb C/EBP-beta DNA-binding; Motility/polarity/chemotaxis; Transcription factor P21272 24253 3q42 rat S111-p 13373504 PSDYGYVsLGRAGAK molecular association, regulation cell growth, induced; transcription, induced DNA(INDUCES) 20351173 1 3 1 +BAD BAD Apoptosis Q92934 572 11q13.1 human S124-p 9938302 MSDEFVDsFKKGLPR Bcl-2_BAD apoptosis, inhibited 21317286 1 4 0 +Kif23 KIF23 Microtubule-binding; Motility/polarity/chemotaxis; Motor E9Q5G3 71819 9|9 B mouse S805-p 2902205 IPVRHRRsRSAGSRW MKLP1_Arf_bdg intracellular localization cell cycle regulation; cytoskeletal reorganization 15199097 5 1 0 regulates cytokinesis +PDGFRB PDGFRB EC 2.7.10.1; KINASE; Kinase, protein; Membrane protein, integral; Oncoprotein; Protein kinase, TK; Protein kinase, tyrosine (receptor) P09619 5159 5q32 human Y857-p 447509 DIMRDSNyISKGSTF PK_Tyr_Ser-Thr phosphorylation; enzymatic activity, induced cell differentiation, inhibited; carcinogenesis, induced; cell motility, induced; cell growth, induced; signaling pathway regulation; cell growth, altered 20494825; 34858182; 35393545 17 2 3 regulates the phosphorylation of DUSP1/p38MAPK and inhibits cell differentiation through the DUSP1/p38MAPK pathway +PRKCD PKCD EC 2.7.11.13; KINASE; Kinase, protein; Nuclear receptor co-regulator; Protein kinase, AGC; Protein kinase, Ser/Thr (non-receptor); Protein kinase, tyrosine (non-receptor); Tumor suppressor Q05655 5580 3p21.1 human Y155-p 447575 IKQAKIHyIKNHEFI intracellular localization apoptosis, induced 28237688 11 0 0 +PAK1 PAK1 EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, STE; Protein kinase, Ser/Thr (non-receptor) Q13153 5058 11q13.5-q14.1 human S174-p 7320951 TPAVPPVsEDEDDDD molecular association, regulation; enzymatic activity, induced cell cycle regulation DYNLL2(INDUCES) 19520772 2 24 6 important for mitotic progression +Vim Vimentin Cytoskeletal; Motility/polarity/chemotaxis P20152 22352 2 A1|2 10.04 cM mouse S7-p 455449 _MSTRSVsSSSYRRM Filament_head molecular association, regulation endocytosis, induced; cytoskeletal reorganization JAG1(INDUCES) 12458200; 28533359 8 21 1 transendocytosis +Pdpk1 PDK1 EC 2.7.11.1; KINASE; Kinase, protein; Nuclear receptor co-regulator; Protein kinase, AGC; Protein kinase, Ser/Thr (non-receptor) Q9Z2A0 18607 17|17 A3.3 mouse S504-p 5938008 LKGEIPWsQELRPEA PH_3 enzymatic activity, inhibited 19047061 1 1 0 +FNIP1 FNIP1 Q8TF40 96459 5q31.1 human S939-p 17550026 DIPRNESsDSALGDS protein stabilization; molecular association, regulation signaling pathway regulation HSP90A(INDUCES) DNA(INDUCES) 30699359 1 2 0 +Akt1 Akt1 EC 2.7.11.1; KINASE; Kinase, protein; Oncoprotein; Protein kinase, AGC; Protein kinase, Ser/Thr (non-receptor) P31750 11651 12 F1|12 61.2 cM mouse S473-gl 4261200 RPHFPQFsYSASGTA Pkinase_C apoptosis, altered 18570920 5 0 0 +ADRB2 ADRB2 GPCR, family 1; Membrane protein, integral; Membrane protein, multi-pass; Receptor, GPCR P07550 154 5q32 human S261-p 447908 TGHGLRRsSKFCLKE 7tm_1 receptor desensitization, inhibited 9461522 9 2 0 like wild type mutant acted in a dominant positive fashion +RBL2 Rb-like 2 Transcription, coactivator/corepressor; Tumor suppressor Q08999 5934 16q12.2 human T642-p 449727 CIAGSPLtPRRVTEV molecular association, regulation cell cycle regulation E2F4(DISRUPTS) 11157749 3 20 44 +APC APC Motility/polarity/chemotaxis; Tumor suppressor P25054 324 5q22.2 human S1510-p 999606 SSSLSALsLDEPFIQ phosphorylation 17910481 1 0 0 phosphorylation by CK1 primes for S1501 phosphorylation by GSK3 +Scarb1 SCARB1 Membrane protein, integral; Membrane protein, multi-pass; Receptor, misc. P97943 25073 12q15 rat S496-p 14567809 AYSESLMsPAAKGTV intracellular localization 26567857 1 3 0 cAMP stimulated selective HDL-CE uptake, SCARB1-mediated and HDL-supported steroid production, nuclear localization to cytoplasm after cAMP stimulation +SYT6 SYT6 Membrane protein, integral; Vesicle Q5T7P8 148281 1p13.2 human T417-p 456500 RRLKKKKtTIKKNTL C2 activity, induced 16111671 1 0 0 +H2AZ1 H2AZ DNA-binding P0C0S5 3015 4q23 human K7-ac 458910 _AGGKAGkDSGKAKT Histone molecular association, regulation transcription, induced FALZ(INDUCES) 32356653 4 14 419 K7ac preferentially engaging the binding site, acetylation at K7ac and K13ac is also the highest-affinity acetylation pattern of isoform I +PACSIN1 PACSIN1 Adaptor/scaffold Q9BY11 29993 6p21.31 human S348-p 4730482 AGDRGSVsSYDRGQP molecular association, regulation PICK1(DISRUPTS) 23918399 1 1 0 regulates AMPAR trafficking +MYBL2 B-Myb DNA-binding; Motility/polarity/chemotaxis; Transcription factor P10244 4605 20q13.12 human T518-p 450111 SMDNTPHtPTPFKNA Cmyb_C molecular association, regulation; protein conformation transcription, induced DNA(INDUCES) 35926712 2 6 20 +APP APP Apoptosis; Cell surface; Membrane protein, integral; Receptor, misc.; Transcription factor P05067 351 21q21.3 human K134-ac 1880082600 LLVPDKCkFLHQERM intracellular localization 35830807 1 1 0 AK7 ameliorates cognitive deficits in APP/PS1 mice via inhibition of K132/134 acetylation; APP acetylation is neuroprotective in cultured hippocampal neurons; APP localization at the cell surface +Tek TIE2 EC 2.7.10.1; KINASE; Kinase, protein; Membrane protein, integral; Protein kinase, TK; Protein kinase, tyrosine (receptor) Q02858 21687 4 C5|4 43.34 cM mouse Y1106-p 448372 TYVNTTLyEKFTYAG molecular association, regulation; phosphorylation cell motility, altered DOK2(INDUCES) 12665569 4 0 1 Mutation of Y1106F reduces tyrosine phosphorylation on Dok-R (Dok2). Mutation prevents Ang1-MH-induced chemotaxis (cannot rescue the null). +AGR2 AGR2 Oncoprotein; Secreted; Secreted, signal peptide O95994 10551 7p21.1 human K89-ub 1877589400 PHSQALKkVFAENKE Thioredoxin_7 protein degradation autophagy, induced; transcription, inhibited 30647455 1 0 0 +Myl12b MRLC2 Contractile Q3THE2 67938 17|17 E1.3 mouse T19-p 448596 KKRPQRAtSNVFAMF apoptosis, inhibited 11485996 36 50 282 +Fam13a FAM13A1 GAP; GAP, Rac/Rho Q8BGI4 58909 6|6 B3 mouse S322-p 3178045 FMRRRSSsLGSYDDE molecular association, regulation; intracellular localization 14-3-3 epsilon(INDUCES) 25609086 1 4 1 +Arhgef2 ARHGEF2 GEF; GEF, Rac/Rho; Motility/polarity/chemotaxis Q60875 16800 3|3 F1 mouse T114-p 12473200 SVSLRSKtTTRERPT molecular association, regulation; activity, inhibited cytoskeletal reorganization DYNLT1(DISRUPTS); 14-3-3 eta(INDUCES) 19667072 1 0 0 14-3-3 and DYNLT1 biind ARHGEF2 in a mutually exclusive manner. +BECN1 beclin 1 Adaptor/scaffold; Autophagy; Membrane protein, peripheral Q14457 8678 17q21.31 human T57-p 4275031 AQAKPGEtQEEETNS autophagy, induced 31260798 2 2 0 +NCOA3 SRC-3 ACETYLTRANSFERASE; Acetyltransferase; EC 2.3.1.48; Motility/polarity/chemotaxis; Nuclear receptor co-regulator; Transcription, coactivator/corepressor Q9Y6Q9 8202 20q13.12 human K723-sm 3817001 CGDGNVVkQEQLSPK DUF4927 transcription, inhibited 16760465 1 0 0 +MEF2A MEF2A DNA-binding; Motility/polarity/chemotaxis; Transcription factor Q02078 4205 15q26.3 human S408-p 449949 SIKSEPIsPPRDRMT acetylation cell differentiation, inhibited; transcription, induced; transcription, altered 12691662; 15340086; 16484498 3 19 0 switch from sumoylation to acetylsation +IQGAP1 IQGAP1 GAP; GAP, Ras; Motility/polarity/chemotaxis P46940 8826 15q26.1 human Y1510-p 450791 LVKLQQTyAALNSKA RasGAP_C activity, induced; phosphorylation cell motility, inhibited 33087447 1 28 912 Akt activation +PELI1 PELI1 Adaptor/scaffold; EC 6.3.2.-; EC 6.3.2.19; Ligase; UBIQUITIN LIGASE; Ubiquitin conjugating system; Ubiquitin ligase Q96FA3 57162 2p14 human Y154-p 3800785 PPFTARIyAAGFDSS Pellino ubiquitination; phosphorylation; enzymatic activity, induced carcinogenesis, induced; cell motility, induced 36841821 1 1 1 +GATA4 GATA4 Motility/polarity/chemotaxis; Transcription factor P43694 2626 8p23.1 human S105-p 449604 AYTPPPVsPRFSFPG GATA-N protein degradation cell differentiation, inhibited; cell growth, induced 21447557 16 0 0 +ING1 ING1 iso2 Tumor suppressor Q9UK53-2 3621 13q34 human S126-p 484008 LGDTAGNsGKAGADR molecular association, regulation; protein stabilization cell growth, inhibited NQO1(INDUCES) 17585055; 18388957 2 0 0 +Rims1 RIMS1 Adaptor/scaffold; Vesicle Q9JIR4 84556 9q13 rat S287-p 455664 KQASRSRsEPPRERK molecular association, regulation 14-3-3 beta(INDUCES); 14-3-3 gamma(INDUCES); 14-3-3 eta(INDUCES) 12871946 2 1 0 +STXBP5L STXBP5L Q9Y2K9 9515 3q13.33 human S763-p 17433705 CTSPTSQsCSSGKRL protein degradation 25002582 1 2 0 ; in a multiple residue S->D mutant +Fyb1 SLAP-130 Adaptor/scaffold O35601 23880 15|15 A1 mouse Y807-p 449430 VDNDGEIyDDIADGC hSH3 molecular association, regulation Src iso1(INDUCES) 16020549 4 3 68 +PRKD2 PRKD2 EC 2.7.11.13; KINASE; Kinase, protein; Motility/polarity/chemotaxis; Protein kinase, CAMK; Protein kinase, Ser/Thr (non-receptor) Q9BZL6 25865 19q13.32 human S244-p 1028300 SSSSSSAsSYTGRPI molecular association, regulation; intracellular localization transcription, induced; signaling pathway regulation Exportin-1(DISRUPTS); 14-3-3 eta(DISRUPTS) 17962809 1 1 1 +DAAM1 DAAM1 Adaptor/scaffold; Motility/polarity/chemotaxis Q9Y4D1 23002 14q23.1 human Y652-p 7791229 LERTFSAyQRQQDFF FH2 molecular association, regulation carcinogenesis, induced; cell motility, induced; cytoskeletal reorganization DAAM1(INDUCES) 31406243 1 1 3 +H2bc15 H2B DNA-binding P10853 319187 13|13 A3.1 mouse S14-p 449904 APAPKKGsKKAVTKA Histone phosphorylation apoptosis, altered 15361883; 16039583 10 1 0 +STAT1 STAT1 DNA-binding; Transcription factor P42224 6772 2q32.2 human T387-p 1870810800 FNILGTHtKVMNMEE STAT_bind intracellular localization; phosphorylation transcription, altered DNA(DISRUPTS) 33096415 1 0 0 increased level of Tyr phosphorylation in T387A muatnt; DNA binding activity increased in T387A mutant +RPS6KB1 p70S6K iso2 EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, AGC; Protein kinase, Ser/Thr (non-receptor); Translation P23443-2 6198 17q23.1 human S429-p 471897 PVSPVKFsPGDFWGR protein conformation 30612880 2 23 76 +EPAS1 HIF2A DNA-binding; Transcription factor Q99814 2034 2p21 human S581-p 1874020206 LAPVAPHsPFLLDKF transcription, altered 34285132 2 0 0 +SNX8 SNX8 Q9Y5X2 29886 7p22.3 human Y126-p 348335701 MLLHKFPyRMVPALP PX molecular association, regulation transcription, induced IKKB(INDUCES) 29180417 1 0 0 +Jun Jun Oncoprotein; Transcription factor P05627 16476 4 C5|4 43.34 cM mouse T93-p 450449 GHITTTPtPTQFLCP Jun molecular association, regulation NPM1(INDUCES); p14ARF(INDUCES) 18316603 9 3 0 +Eif4b EIF4B RNA-binding; Translation; Translation initiation Q8BGD9 75705 15|15 F2 mouse S422-p 451290 RERSRTGsESSQTGA translation, altered 18836482 11 54 482 +CEBPB C/EBP-beta DNA-binding; Motility/polarity/chemotaxis; Transcription factor P17676 1051 20q13.13 human S76-p 456166 HERAIDFsPYLEPLG phosphorylation transcription, induced 20730378; 23782693 8 0 1 +Adrb2 ADRB2 GPCR, family 1; Membrane protein, integral; Membrane protein, multi-pass; Receptor, GPCR P18762 11555 18 E1|18 35.1 cM mouse S356-p 458917 TYGNGYSsNSNGRTD receptor internalization, induced; receptor internalization, altered cell motility, induced; signaling pathway regulation 18056263; 25460042; 27541735; 31088898 27 2 0 IRS2 is required for ADRB2 internalization; B-arrestin mediated signaling; internalization and the contraction response +Mecp2 MECP2 Transcription, coactivator/corepressor Q00566 29386 Xq37 rat S421-p 470075 EKMPRAGsLESDGCP activity, induced; molecular association, regulation cell differentiation, altered; transcription, induced; translation, inhibited DGCR8(DISRUPTS) 17046689; 33963280 15 13 0 CMW-induced increase in miR101a expression, decrease in Twf1 protein expression and production of CPA behavior +CD44 CD44 iso2 Cell adhesion; Membrane protein, integral; Motility/polarity/chemotaxis; Receptor, misc. P15379-2 12505 2 E2|2 54.13 cM mouse S327-p 450988 LNGEASKsQEMVHLV cell adhesion, induced 7528778 12 58 37 hyaluronate binding is diminished when this residue is mutated +TPX2 TPX2 Cell cycle regulation; Microtubule-binding Q9ULW0 22974 20q11.21 human S125-p 459997 QRRSLRLsAQKDLEQ molecular association, regulation cell cycle regulation CLASP1(INDUCES) 26240182 2 22 17 required for normal spindle length +CYFIP2 CYFIP2 iso2 Cell adhesion; Motility/polarity/chemotaxis Q96F07-2 26999 5q33.3 human T1067-p 4726011 PLIERLGtPQQIAIA FragX_IP cytoskeletal reorganization 28692454 1 12 0 stubby spine density and neurite outgrowth +Lyn LYN EC 2.7.10.2; KINASE; Kinase, protein; Oncoprotein; Protein kinase, TK; Protein kinase, tyrosine (non-receptor) P25911 17096 4 A1|4 2.05 cM mouse Y194-p 454856 SLDNGGYyISPRITF SH2 molecular association, regulation 25587033 2 30 528 Lyn SH2 at Y194 results in only a modest reduction in phospho-peptide binding affinity +Carm1 CARM1 EC 2.1.1.125; METHYLTRANSFERASE; Methyltransferase; Methyltransferase, protein arginine; Nuclear receptor co-regulator Q9WVG6 59035 9|9 A3 mouse T132-p 125971700 LKTCRGHtLERSVFS CARM1 protein stabilization 28637674 1 0 0 +HMGCR HMGCR EC 1.1.1.34; Endoplasmic reticulum; Membrane protein, integral; Membrane protein, multi-pass; Motility/polarity/chemotaxis; Oxidoreductase; Secondary Metabolites Metabolism - terpenoid backbone biosynthesis P04035 3156 5q13.3 human K89-ub 55607400 NLRQLGSkYILGIAG Sterol-sensing protein degradation; ubiquitination 31323021 2 0 0 mutationsdid not reduce sterol-induced degradation of HMGCR, Ubiad1 (WT) or Ubiad1 (G184R) did not increase the amount of mutant HMGCR (K89R, K248R) +SDCBP syntenin Adaptor/scaffold; Cell adhesion; Cytokine; Membrane protein, integral; Motility/polarity/chemotaxis; Vesicle O00560 6386 8q12.1 human S6-p 4148819 __MSLYPsLEDLKVD molecular association, regulation ubiquitin(DISRUPTS) 21949238 2 18 0 +SFN 14-3-3 sigma Adaptor/scaffold P31947 2810 1p36.11 human S74-p 454997 QKSNEEGsEEKGPEV 14-3-3 molecular association, regulation; phosphorylation carcinogenesis, induced; cell growth, induced; transcription, induced; signaling pathway regulation SMAD3(INDUCES); p53(DISRUPTS) DNA(INDUCES) 23741479 2 7 0 Regulates stemness and radioresistance in breast cancer cells; increase phosphorylation of P53 at S15 by mutation of site S74 (S74A) and regulates transcription of P21; TGFb/Smad3 and p53/21 signaling pathways +NRIP1 RIP140 Nuclear receptor co-regulator; Transcription, coactivator/corepressor P48552 8204 21q11.2-q21.1 human R239-m1 2363402 EPLSCAArLQAVASM NRIP1_repr_1 molecular association, regulation; intracellular localization transcription, induced Exportin-1(INDUCES); HDAC3(DISRUPTS) DNA(DISRUPTS) 17053781 2 2 0 +Cebpb C/EBP-beta DNA-binding; Motility/polarity/chemotaxis; Transcription factor P28033 12608 2 H3|2 87.58 cM mouse K216-ac 458940 PAKAKAKkTVDKLSD molecular association, regulation transcription, inhibited DNA(DISRUPTS) 22865229 4 1 0 +DVL3 DVL3 Motility/polarity/chemotaxis Q92997 1857 3q27.1 human S611-p 34668129 ESDHTTRsSLRGPRE Dsh_C intracellular localization 24993822 1 1 0 +Mkln1 MKLN1 Cell adhesion; Motility/polarity/chemotaxis O89050 27418 6|6 A3.3 mouse T515-p 474505 MVPMTGFtQRATIDP molecular association, regulation MKLN1(INDUCES) 17049906 1 0 0 mutation inhibited MKLN1 self-association +SND1 SND1 RNA-binding; Transcription, coactivator/corepressor Q7KZF4 27044 7q32.1 human S426-p 3203808 VDYIRPAsPATETVP SNase cell cycle regulation; transcription, induced 25627688 2 39 10 gene transcriptional activation of cyclin A and E2F-1 +PDE4D PDE4D iso6 EC 3.1.4.53; Nucleotide Metabolism - purine; Phosphodiesterase Q08499-6 5144 5q11.2-q12.1 human K78-ub 7388018 LLSSNIPkQRRFTVA molecular association, regulation RACK1(DISRUPTS); ARRB1(INDUCES) 19372219 1 0 0 +Cttn Cortactin Actin-binding; Cytoskeletal; Motility/polarity/chemotaxis Q60598 13043 7|7 F5 mouse S417-p 465632 PIEDRPPsSPIYEDA cell cycle regulation; cell motility, altered 18515860 1 43 55 +Map2 MAP2 iso3 Cytoskeletal; Motility/polarity/chemotaxis P15146-3 25595 9q32 rat K369-ac 62495505 RVKIESVkLDFKEKA Tubulin-binding cytoskeletal reorganization 28002468 1 1 0 +AR AR DNA-binding; Nuclear receptor; Transcription factor P10275 367 Xq12 human K846-ub 7911901 LDRIIACkRKNPTSC Hormone_recep protein degradation; molecular association, regulation; ubiquitination; intracellular localization transcription, induced RNF14(INDUCES) DNA(INDUCES) 19345326; 31620784; 35163481 5 1 0 required for ubiquitination at K848 +ETS1 Ets-1 DNA-binding; Motility/polarity/chemotaxis; Oncoprotein; Transcription factor P14921 2113 11q24.3 human T38-p 447950 CADVPLLtPSSKEMM activity, induced; protein stabilization; molecular association, regulation; ubiquitination carcinogenesis, induced; cell growth, inhibited; cell differentiation, induced; apoptosis, inhibited; transcription, induced; transcription, altered; cell growth, altered HUWE1(DISRUPTS) 12048211; 21441955; 32131547; 34900980; 8552081; 8761310 14 4 5 Substitution of T38A enhances Ets-1 rescue of CSFR defective receptor (Y809F). ; inhibits ubiquitination +Tgif1 TGIF DNA-binding; Nuclear receptor co-regulator; Transcription, coactivator/corepressor P70284 21815 17|17 E1.3 mouse K130-ub 40212806 IEAAMGIkNFMPTLE protein degradation carcinogenesis, inhibited; cell growth, inhibited 23911286 1 0 0 +Tp53 p53 Activator; DNA-binding; Motility/polarity/chemotaxis; Nuclear receptor co-regulator; Transcription factor; Tumor suppressor P02340 22059 11 B3|11 42.83 cM mouse K98-ac 59149204 SSFVPSQkTYQGNYG P53 cell cycle regulation; carcinogenesis, inhibited; apoptosis, induced 33303641 2 1 0 senescence, ferroptosis, failed to develop early-onset tumors +NREP P311 Motility/polarity/chemotaxis Q16612 9315 5q22.1 human S59-p 457551 LGSSELRsPRISYLH Alveol-reg_P311 protein degradation cell motility, altered; cell adhesion, altered 16229809 1 0 0 P311 S59D and S59E mutants fail to activate Rac1 GTPase +ESR1 ER-alpha DNA-binding; Nuclear receptor; Transcription factor P03372 2099 6q25.1-q25.2 human S46-p 12127401 LGEVYLDsSKPAVYN Oest_recep activity, induced transcription, altered 20043841 1 0 0 +Nsf NSF Adaptor/scaffold; Autophagy; EC 3.6.4.6; Protease; Vesicle P46460 18195 11 E1|11 67.54 cM mouse S569-p 460358 FPFIKICsPDKMIGF AAA molecular association, regulation exocytosis, altered NSF(INDUCES) 16461345 1 2 4 inhibits oligomerization, modulates exocytosis +Atf4 ATF-4 DNA-binding; Transcription factor Q06507 11911 15 E1|15 37.85 cM mouse S251-p 451447 NLPSPGGsRGSPRPK activity, induced cell growth, altered 15109498 1 0 0 +Mybpc3 MYBPC3 Myosin-binding P56741 295929 3q24 rat S279-p 471079 RSAFRRTsLAGTGRR cytoskeletal reorganization 35288601 25 9 14 +SMAD2 SMAD2 DNA-binding; Transcription factor Q15796 4087 18q21.1 human S245-p 448794 NQSMDTGsPAELSPT activity, induced; protein stabilization; molecular association, regulation; intracellular localization; protein conformation cell differentiation, induced; cell motility, altered; transcription, induced SETD2(INDUCES); SMAD4(INDUCES) RNA(INDUCES) 10197981; 12193595; 19115199; 27153775; 31995604; 34504019 12 0 0 +NFE2 NF-E2 Cytoskeletal; DNA-binding; Transcription factor Q16621 4778 12q13.13 human K215-ub 11489904 SSGPVRAkPTARGEA protein degradation; ubiquitination transcription, inhibited 19966288 1 0 0 +Gprc5b GPRC5B GPCR, family 3; Membrane protein, integral; Membrane protein, multi-pass; Receptor, GPCR Q923Z0 64297 7|7 F2 mouse Y383-p 462507 APFRSNVyQPTEMAV molecular association, regulation; phosphorylation signaling pathway regulation Fyn(INDUCES) 23169819 1 9 106 induces phosphorylation of Caveolin1 and induces abundance of IKKE, and IKKE-NF-KB signaling ; induces phosphorylation of Cav1 and inflammatory signaling in adipose tissue +Brsk2 BRSK2 EC 2.7.11.1; EC 2.7.11.26; KINASE; Kinase, protein; Protein kinase, CAMK; Protein kinase, Ser/Thr (non-receptor) Q69Z98 75770 7|7 F5 mouse S428-p 4734873 LSTSPLSsPRVTPHP protein stabilization; enzymatic activity, inhibited; phosphorylation 23790753 1 8 1 inhibits axon branching (activated in BRSK2 18A mutant) +RHOA RHOA G protein; G protein, monomeric; G protein, monomeric, Rho; Motility/polarity/chemotaxis; Oncoprotein P61586 387 3p21.31 human K135-ub 486702 RRELAKMkQEPVKPE Ras protein degradation 23871831 1 9 99 +DARS1 DARS Aminoacyl-tRNA synthetase; EC 6.1.1.12; Ligase; Translation; Translation regulation P14868 1615 2q21.3 human S146-p 18008485 VQKIYVIsLAEPRLP protein conformation 23609930 0 2 0 +Mlkl MLKL KINASE; Kinase, protein; Protein kinase, Ser/Thr (non-receptor); Protein kinase, TKL Q9D2Y4 74568 8|8 E1 mouse S345-p 22996309 ELSKTQNsISRTAKS PK_Tyr_Ser-Thr activity, induced; molecular association, regulation; intracellular localization; protein conformation apoptosis, induced; signaling pathway regulation MLKL(INDUCES) 26024392; 30442947; 31748744; 32094226; 33221042; 34239062; 34782457 36 3 0 +CAV2 caveolin-2 Adaptor/scaffold; Motility/polarity/chemotaxis P51636 858 7q31.2 human S135-p 2765000 SVQTIWKsVTDVIIA Caveolin activity, induced 12743374 1 0 0 formation of caveolae +LDHA LDH-A Amino Acid Metabolism - cysteine and methionine; Apoptosis; Carbohydrate Metabolism - glycolysis and gluconeogenesis; Carbohydrate Metabolism - propanoate; Carbohydrate Metabolism - pyruvate; EC 1.1.1.27; Oxidoreductase P00338 3939 11p15.1 human Y83-p 3780568 KIVSGKDyNVTANSK Ldh_1_N enzymatic activity, induced 21969607 1 1 8 +TRPM2 TRPM2 iso3 Channel, calcium; EC 3.6.1.13; Hydrolase; Membrane protein, integral; Membrane protein, multi-pass; Transporter O94759-3 7226 21q22.3 human S39-p 30312508 NLRRSNSsLFKSWRL apoptosis, induced 24337049 1 0 0 induces Ca2+ entry and apoptosis +KRT19 K19 Cytoskeletal P08727 3880 17q21.2 human K208-sm 25027604 EMQIEGLkEELAYLK Filament cytoskeletal reorganization 21062750 1 0 0 sumoylation regulate solubility; modified by poly-SUMO-2/3 chains, oxidative stress, apoptosis, and/or phosphatase inhibition increase sumoylation in primary hepatocytes; K to R mutants show filament disorganization +HDAC6 HDAC6 DEACETYLASE; Deacetylase; EC 3.5.1.98; Nuclear receptor co-regulator; Ubiquitin conjugating system Q9UBN7 10013 Xp11.23 human S43-p 4759159 KKGAVPRsIPNLAEV molecular association, regulation cell motility, induced PIN1(INDUCES) 30443180 1 3 0 nteraction of HDAC6 with Pin1 mediates cell motility +SP1 SP1 C2H2-type zinc finger protein; DNA-binding; Transcription factor P08047 6667 12q13.13 human S698-gl 5262506 CPKRFMRsDHLSKHI zf-C2H2 transcription, induced 18513490 2 1 0 +Trim71 TRIM71 UBIQUITIN LIGASE; Ubiquitin conjugating system; Ubiquitin ligase Q1PSW8 636931 9|9 F3 mouse S3-p 18914372 _____MAsFPETDFQ protein stabilization; molecular association, regulation; ubiquitination carcinogenesis, inhibited UBE1(DISRUPTS); UBE2D3(DISRUPTS); ubiquitin(DISRUPTS) 31160797 1 2 0 inhibits ubiquitination +CALR Calreticulin ACETYLTRANSFERASE; Acetyltransferase; Calcium-binding; Motility/polarity/chemotaxis; Nuclear receptor co-regulator; Secreted; Secreted, signal peptide P27797 811 19p13.13 human K206-ac 4219812 DWDFLPPkKIKDPDA Calreticulin protein conformation 18795239 1 2 0 +GSK3B GSK3B EC 2.7.11.1; EC 2.7.11.26; KINASE; Kinase, protein; Protein kinase, CMGC; Protein kinase, Ser/Thr (non-receptor) P49841 2932 3q13.33 human K86-ub 1870957200 GELVAIKkVLQDKRF Pkinase activity, inhibited 30711629 0 1 0 +SIRT6 SIRT6 DEACETYLASE; DEUBIQUITINASE; Deacetylase; EC 2.4.2.31; EC 3.5.1.-; Transferase Q8N6T7 51548 19p13.3 human K128-ub 573777002 RSGFPRDkLAELHGN SIR2 protein degradation carcinogenesis, induced 33903120 1 1 0 +Polr2a POLR2A EC 2.7.7.48; EC 2.7.7.6; Nucleotide Metabolism - purine; Nucleotide Metabolism - pyrimidine; Transcription initiation complex; Transferase P08775 20020 11 B3|11 42.86 cM mouse K1873-ub 2134720 KYSPTSPkYSPTSPT RNA_pol_Rpb1_R protein degradation 17526739 1 1 0 +H2AX H2AX DNA repair, damage; DNA-binding; Helicase P16104 3014 11q23.3 human K5-ac 482536 ___SGRGkTGGKARA Histone ADP-ribosylation; intracellular localization; phosphorylation DNA repair, induced 19895790; 26438602; 26976643 5 3 63 induces ribosylation of PARP1 +CDH1 CDH1 Cell adhesion; Membrane protein, integral; Motility/polarity/chemotaxis; UBIQUITIN LIGASE; Ubiquitin ligase P12830 999 16q22.1 human T790-p 55578700 TRNDVAPtLMSVPRY molecular association, regulation; activity, inhibited CTNNB1(DISRUPTS); CBLL1(DISRUPTS) 27203386 1 0 0 impairs homophilic interaction at cell-cell contacts +SMARCAL1 SMARCAL1 EC 3.6.1.-; EC 3.6.4.-; Helicase Q9NZC9 50485 2q35 human S173-p 29606709 PLAKPKSsQETPAHS protein degradation 30996091 1 2 0 +E2F1 E2F1 DNA-binding; Transcription factor Q01094 1869 20q11.22 human S403-p 447870 PEEFISLsPPHEALD protein degradation; molecular association, regulation; ubiquitination; intracellular localization; protein conformation cell cycle regulation; cell differentiation, altered; transcription, altered; cell growth, altered PRB1(INDUCES) 10428966; 18794805; 20447425; 20616879; 27903963 7 0 0 regulation of cell transformation efficiency, target gene expression altered +ADRB2 ADRB2 GPCR, family 1; Membrane protein, integral; Membrane protein, multi-pass; Receptor, GPCR P07550 154 5q32 human S407-p 457443 DSQGRNCsTNDSLL_ protein conformation 21868357 4 1 0 +POLB POLB DNA repair, damage; DNA replication; EC 2.7.7.7; Lyase; Transferase P06746 5423 8p11.21 human K206-ub 56841101 SFTSESTkQPKLLHQ DNA_pol_B_palm protein degradation; ubiquitination 25423885 1 0 0 +NDUFA9 NUEM EC 1.6.5.3; EC 1.6.99.3; Energy Metabolism - oxidative phosphorylation; Mitochondrial; Oxidoreductase Q16795 4704 12p13.32 human K189-ac 33351156 RNKAVGEkVVRDAFP Epimerase activity, inhibited 27508876 1 3 0 inhibits Complex 1 activity +Irx3 IRX3 DNA-binding P81067 16373 8 C5|8 44.55 cM mouse K409-ub 1874748508 LVSAPLGkFPAWTNR protein degradation transcription, inhibited 34556885 1 0 0 +PPP1R1A PPP1R1A Inhibitor; Protein phosphatase, regulatory subunit Q13522 5502 12q13.2 human T75-p 471085 PRQRKKMtRITPTMK DARPP-32 phosphorylation; enzymatic activity, induced cytoskeletal reorganization 17046826; 17416610 2 0 0 decreased contractility, and decreased PLB phosphorylation in PPP1R1A S67D and T75D mutants; Phosphorylation of PPP1R1A at T75 induces PP1 activity in isolated myocytes and in vitro. Phosphorylation of T75 significantly depresses myocyte contractility, by reducing cardiac contractility by reducing Ca2+ affinity of SERCA2a. +KCNN1 KCNN1 Membrane protein, integral; Membrane protein, multi-pass Q92952 3780 19p13.11 human Y109-p 17436177 KRKRLSDyALIFGMF SK_channel activity, induced 23496660 1 1 1 +FBP1 FBPase Carbohydrate Metabolism - fructose and mannose; Carbohydrate Metabolism - glycolysis and gluconeogenesis; Carbohydrate Metabolism - pentose phosphate pathway; EC 3.1.3.11; Mitochondrial; Phosphatase (non-protein) P09467 2203 9q22.32 human K110-ac 1876844501 AIIVEPEkRGKYVVC FBPase molecular association, regulation carcinogenesis, inhibited; transcription, inhibited BRD4(INDUCES) 32195024 1 0 0 +Atat1 ATAT1 iso2 ACETYLTRANSFERASE; Acetyltransferase; EC 2.3.1.108 Q8K341-2 73242 17|17 B1 mouse K210-ac 11322008 KRAEGDIkPYSSSDR enzymatic activity, induced 23275437 1 5 0 +GRIN2B NMDAR2B Channel, calcium; Channel, ligand-gated; Membrane protein, integral; Membrane protein, multi-pass Q13224 2904 12p13.1 human S1166-p 481156 SDDFKRDsVSGGGPC NMDAR2_C activity, induced 24431445 3 2 1 NMDAR potentiation and Ca2+ signaling in spines +CD274 PD-L1 Membrane protein, integral Q9NZQ7 29126 9p24.1 human S195-p 796148000 EKLFNVTsTLRINTT C2-set_2 protein degradation; ubiquitination; intracellular localization; N-GlcNAc glycosylation carcinogenesis, inhibited; RNA stability, inhibited; DNA repair, inhibited; signaling pathway regulation 30118680; 35181605 2 1 0 +Map2 MAP2 iso3 Cytoskeletal; Motility/polarity/chemotaxis P15146-3 25595 9q32 rat K273-ac 62495514 PRTPGTPkSGILVPS cytoskeletal reorganization 28002468 1 1 0 +CCDC6 CCDC6 Apoptosis; Cytoskeletal; Oncoprotein Q16204 8030 10q21.2 human T434-p 479429 TPPPSPNtQTPVQPP protein stabilization; molecular association, regulation; intracellular localization apoptosis, altered FBXW7(DISRUPTS) 17420723; 23108047; 24059746 3 0 0 nuclear localization +AKAP8 AKAP8 Adaptor/scaffold; Cell cycle regulation; Mitochondrial; RNA-binding O43823 10270 19p13.12 human Y146-p 40420002 CLPEHNPyRPSYSYD molecular association, regulation 25770215 1 0 0 Phenylalanine mutants inhibited dissociation from nuclear structures; structural chromatin changes +YAP1 YAP1 Oncoprotein; Transcription, coactivator/corepressor P46937 10413 11q22.1 human K494-me 55591500 ESVLAATkLDKESFL molecular association, regulation axin 1(INDUCES) 27046831 2 0 0 +Pdcd1 PD-1 Apoptosis; Membrane protein, integral Q02242 18566 1|1 D mouse Y225-p 50293000 APVPSVAyEELDFQG cell growth, induced 26359984 3 1 0 increased three-dimensional tumor growth +MAPT Tau iso3 ACETYLTRANSFERASE; Acetyltransferase; Cytoskeletal P10636-3 4137 17q21.31 human S279-p 449082 PVVSGDTsPRHLSNV molecular association, regulation cytoskeletal reorganization 10747907 145 54 69 regulates association with membrane +Oprd1 DOR-1 GPCR, family 1; Membrane protein, integral; Membrane protein, multi-pass; Receptor, GPCR P33533 24613 5q36 rat T161-p 455533 VKALDFRtPAKAKLI 7tm_1 molecular association, regulation; intracellular localization MOR-1(INDUCES) 19295160; 22466129 3 0 0 regulates heat and inflammatory hypersensitivity , induces morphine tolerance; involved in morphine antinociceptive tolerance +Cryab CRYAB Chaperone; Heat shock protein P23927 12955 9 A5.3|9 27.75 cM mouse S45-p 448748 FSTATSLsPFYLRPP Crystallin protein degradation; molecular association, regulation; intracellular localization signaling pathway regulation 28196893; 29088822 35 7 1 phosphorylation of this site stimulates interaction with multiple proteins and activates multiple pathways; induces reactive astrogliosis +INSIG2 INSIG2 Endoplasmic reticulum; Membrane protein, integral; Membrane protein, multi-pass; Transcription, coactivator/corepressor Q9Y5U4 51141 2q14.1-q14.2 human S151-p 1868515112 LWWTFDRsRSGFGLG INSIG activity, induced; protein degradation; molecular association, regulation carcinogenesis, induced; cell growth, induced; apoptosis, inhibited; transcription, induced SCAP(INDUCES) 32322062; 33842305 2 1 0 +Prkcb PKCB EC 2.7.11.13; KINASE; Kinase, protein; Motility/polarity/chemotaxis; Protein kinase, AGC; Protein kinase, Ser/Thr (non-receptor) P68403 25023 1q36 rat S661-p 448672 QNEFAGFsYTNPEFV Pkinase_C protein conformation 21215369 12 1 0 +KIT Kit EC 2.7.10.1; KINASE; Kinase, protein; Membrane protein, integral; Oncoprotein; Protein kinase, TK; Protein kinase, tyrosine (receptor) P10721 3815 4q12 human S746-p 450036 RRSVRIGsYIERDVT PK_Tyr_Ser-Thr enzymatic activity, inhibited; phosphorylation 7539802 2 5 0 +Sgo2a SGOL2 Unknown function Q7TSY8 68549 1 C1.3|1 28.86 cM mouse T600-p 89115100 KQKINRRtKIISVMS intracellular localization 28502659 1 0 0 dissociation from chromosome arms +TTK TTK Cancer Testis Antigen (CTA); EC 2.7.12.1; KINASE; Kinase, protein; Protein kinase, Other; Protein kinase, dual-specificity (non-receptor) P33981 7272 6q14.1 human K848-ub 21187452 SHNSSSSkTFEKKRG protein degradation cell cycle regulation 34586601 1 3 0 +TAOK3 TAO3 EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, STE; Protein kinase, Ser/Thr (non-receptor) Q9H2K8 51347 12q24.23 human S324-p 468901 RNGPLNEsQEDEEDS activity, induced cell cycle regulation 17396146 2 52 11 +Nrip1 RIP140 Nuclear receptor co-regulator; Transcription, coactivator/corepressor Q8CBD1 268903 16|16 C3.1 mouse K607-ac 459040 LMDLTKGkESQAEKP NRIP1_repr_2 intracellular localization transcription, inhibited 15879431 0 2 0 +TP53 p53 Activator; DNA-binding; Motility/polarity/chemotaxis; Nuclear receptor co-regulator; Transcription factor; Tumor suppressor P04637 7157 17p13.1 human S149-p 456326 PVQLWVDsTPPPGTR P53 protein degradation; molecular association, regulation; ubiquitination cell cycle regulation; cell growth, inhibited; apoptosis, induced; transcription, induced FBXO42(INDUCES) 21127074 3 0 1 +Dok2 DOK2 Adaptor/scaffold O70469 13449 14 D2|14 36.71 cM mouse Y304-p 448880 PGAPEGEyAVPFDTV molecular association, regulation cell differentiation, altered; cell growth, altered RASA1(INDUCES) 10428862; 10508618; 12093790 3 22 745 +BID BID Apoptosis; Mitochondrial P55957 637 22q11.21 human S67-p 14570494 DGNRSSHsRLGRIEA BID cell cycle regulation; cell differentiation, induced; apoptosis, induced; apoptosis, inhibited 24767991; 36202990 2 5 0 +GHR GH receptor Membrane protein, integral; Receptor, cytokine NP_999419 397488 pig Y627-p 486258 EFLSSCGyVSTDQLN transcription, induced DNA(INDUCES) 8647880 3 0 0 +Akt1s1 PRAS40 Apoptosis Q9D1F4 67605 7|7 B3 mouse T247-p 470067 LPRPRLNtSDFQKLK PRAS phosphorylation 20138985 50 69 781 required for phosphorylation of PRAS40 S184 +Irs1 IRS1 Adaptor/scaffold; Motility/polarity/chemotaxis P35570 25467 9q34 rat S570-p 451681 RLPGYRHsAFVPTHS molecular association, regulation PIK3R1(DISRUPTS) 15134463 4 5 0 +GAB2 GAB2 Adaptor/scaffold Q9UQC2 9846 11q14.1 human Y643-p 450913 TSDEKVDyVQVDKEK molecular association, regulation; phosphorylation cell cycle regulation; transcription, altered SHP-2(INDUCES) 15170389; 18644434; 23980151 4 11 190 activates Erk1/2 and regulates cells proliferation; Binding of SHP-2 activates the MAPK pathway and transcription. +MALT1 MALT1 Adaptor/scaffold; Apoptosis; EC 3.4.22.-; Ligase; Nuclear export; Protease; UBIQUITIN LIGASE; Ubiquitin conjugating system Q9UDY8 10892 18q21.32 human K709-ub 2134708 KQEVNVGkPLIAKLD MALT1_Ig protein degradation; molecular association, regulation IKKA(INDUCES) 17948050 1 1 0 activation of NF-kB pathway and IL-2 induction +H2AC11 H2A.1 DNA-binding P0C0S8 8329 6p22.1 human K119-ub 482913 QAVLLPKkTESHHKA Histone_H2A_C molecular association, regulation; ubiquitination; intracellular localization cell differentiation, inhibited; cell cycle regulation; carcinogenesis, induced; cell motility, induced; cell growth, inhibited; DNA repair, induced; autophagy, induced; chromatin organization, altered; cell growth, induced; cytoskeletal reorganization; transcription, inhibited DNA(INDUCES) 15386022; 15525528; 16702407; 19503595; 19791798; 25578731; 26416890; 26738589; 27716482; 28073915; 30992312; 32427989; 32571933; 33328315; 35346195 48 14 146 BMI1 directly binds to the promoter region of SIK1and promotes monoubiquitination of histone H2A.1K119, and inhibits H3K4me BMI1 inhibits SIK1 increasing proliferation and metastasis +IFITM1 IFITM1 Cell cycle regulation; Membrane protein, integral; Membrane protein, multi-pass P13164 8519 11p15.5 human K122-ub 37045601 MLQIIQEkRGY____ molecular association, regulation; intracellular localization AP3M1(INDUCES); AP3M2(INDUCES) 25527505 1 0 0 mutants K122A, R123A, KR/AA and 4KR+KR/AA, but not K122R and 4KR showed decreased or complete loss of interaction with u3A and u3B; -Regulation of endocytic trafficking and viral entry into the cell +Ralgds RALGDS GEF; GEF, Ras Q03385 19730 2|2 A3 mouse Y752-p 59087905 DVDNGNMyKSILVTS RA molecular association, regulation KRas(DISRUPTS); HRas(DISRUPTS) 27773821 1 1 0 +ALK ALK EC 2.7.10.1; KINASE; Kinase, protein; Membrane protein, integral; Oncoprotein; Protein kinase, TK; Protein kinase, tyrosine (receptor) Q9UM73 238 2p23.2-p23.1 human Y1584-p 450380 FPCGNVNyGYQQQGL molecular association, regulation IRS2(INDUCES) 30459283 0 4 36 +Ptpre PTPRE iso2 EC 3.1.3.48; Membrane protein, integral; Motility/polarity/chemotaxis; PHOSPHATASE; Receptor protein phosphatase, tyrosine P49446-2 19267 7 F3|7 81.27 cM mouse Y638-p 450705 FIDIFSDyANFK___ molecular association, regulation cell adhesion, altered Pyk2(INDUCES); Src(INDUCES) 19692574 4 22 597 +CBLB Cbl-b Adaptor/scaffold; Calcium-binding; EC 6.3.2.-; Ligase; UBIQUITIN LIGASE; Ubiquitin conjugating system; Ubiquitin ligase Q13191 868 3q13.11 human Y709-p 475085 VEEDDDEyKIPSSHP molecular association, regulation CRKL(INDUCES) 10022120 3 6 115 in vitro and vivo; Y709 is major binding site, and to lesser extent Y665 +HMGN1 HMGN1 DNA-binding; Nuclear receptor co-regulator P05114 3150 21q22.2 human K82-ac 458854 PAENGETkTEESPAS HMG14_17 molecular association, regulation DNA(DISRUPTS) 10753971 1 1 0 +IFNAR2 IFNAR2 Membrane protein, integral; Receptor, cytokine P48551 3455 21q22.11 human Y318-p 14574802 KKVWDYNyDDESDSD molecular association, regulation transcription, induced; signaling pathway regulation STAT2(DISRUPTS) 34813358 2 0 0 induces STAT phosphorylation and signaling +ZC3HC1 NIPA Cell cycle regulation; Ubiquitin conjugating system Q86WB0 51530 7q32.2 human S381-p 14576869 RTRPVTRsMGTGDTP molecular association, regulation; intracellular localization cell growth, induced NPM-ALK(DISRUPTS) 31434245 1 9 1 +Pygb PYGB Carbohydrate Metabolism - starch and sucrose; EC 2.4.1.1; Kinase, other; Phosphorylase; Transferase Q8CI94 110078 2 G3|2 74.74 cM mouse S15-p 456885 SERQKQIsVRGIAGL signaling pathway regulation 21668450 4 17 1 regulation of glycogen synthesis via R3F-PP1 signaling in astrocytoma cells +CREBBP CBP ACETYLTRANSFERASE; Acetyltransferase; DNA-binding; EC 2.3.1.48; Motility/polarity/chemotaxis; Nuclear receptor co-regulator; Transcription, coactivator/corepressor Q92793 1387 16p13.3 human R2151-me 1872850902 AMQAGVPrPGVPPQQ molecular association, regulation; acetylation; enzymatic activity, induced RAC3(INDUCES); ER-alpha(INDUCES) DNA(INDUCES) 21632823 1 0 0 induces CBP autoacetylation +TP53 p53 Activator; DNA-binding; Motility/polarity/chemotaxis; Nuclear receptor co-regulator; Transcription factor; Tumor suppressor P04637 7157 17p13.1 human K386-sm 2255102 RHKKLMFkTEGPDSD activity, induced; sumoylation; molecular association, regulation apoptosis, induced; autophagy, inhibited; transcription, inhibited; transcription, altered DNA(DISRUPTS) 10562558; 10788439; 17012228; 19339993; 19838051; 35187108 14 3 0 K386 SUMOylation mediates AOPP-BSA-induced endothelial vascular senescence and apoptosis evasion +DIAPH2 Diaphanous-2 Cytoskeletal; Motility/polarity/chemotaxis O60879 1730 Xq21.33 human K970-ac 63341500 TMHNNMMkLYENLGE FH2 cytoskeletal reorganization 28255013 1 0 0 regulates cytokinesis and erythrocyte enucleation +FOXM1 FOXM1 DNA-binding; Transcription factor Q08050 2305 12p13.33 human S704-p 449265 IDVPKPGsPEPQVSG activity, induced; molecular association, regulation; protein stabilization cell growth, induced; transcription, induced PIN1(INDUCES) 22094256; 26279295 2 6 0 +PRKD2 PRKD2 EC 2.7.11.13; KINASE; Kinase, protein; Motility/polarity/chemotaxis; Protein kinase, CAMK; Protein kinase, Ser/Thr (non-receptor) Q9BZL6 25865 19q13.32 human S706-p 449864 ARIIGEKsFRRSVVG Pkinase molecular association, regulation; enzymatic activity, induced transcription, induced; signaling pathway regulation 14-3-3 eta(INDUCES); Exportin-1(DISRUPTS); 14-3-3 eta(DISRUPTS) 12058027; 17962809 5 10 21 +REPS2 REPS2 Adaptor/scaffold; G protein regulator, misc. Q8NFH8 9185 Xp22.2 human S463-p 480114 RPRSRSYsSTSIEEA molecular association, regulation AP2A1(DISRUPTS) 10764745 1 6 4 Phosphorylation inhibits during mitosis +Irs1 IRS1 Adaptor/scaffold; Motility/polarity/chemotaxis P35570 25467 9q34 rat S357-p 4859802 HAHRHRGsSRLHPPL molecular association, regulation; phosphorylation PKCD(INDUCES) 18285345 2 0 0 leads to reduced phosphorylation of Akt +POLB POLB DNA repair, damage; DNA replication; EC 2.7.7.7; Lyase; Transferase P06746 5423 8p11.21 human K61-ub 12723500 KSGAEAKkLPGVGTK HHH_8 protein degradation DNA repair, inhibited 19713937 1 1 0 +FLI1 FLI1 DNA-binding; Oncoprotein; Transcription factor Q01543 2313 11q24.3 human K334-ub 62489906 KPNMNYDkLSRALRY Ets protein degradation 27875302 1 1 0 +EDC3 EDC3 RNA processing Q96F86 80153 15q24.1 human Y475-p 1880539206 GEHAGRIyLCDIGIP molecular association, regulation; phosphorylation DCP1A(DISRUPTS); DCP1B(DISRUPTS); DDX6(DISRUPTS) 36476517 1 1 0 primes phosphorylation at S131 and S161 +MPZ myelin P0 Adaptor/scaffold; Membrane protein, integral P25189 4359 1q23.3 human Y220-p 450106 GRQTPVLyAMLDHSR Myelin-PO_C molecular association, regulation 10673375 3 1 1 promotes association with 42, 68, and 85 kDa tyrosine phosphorylated proteins +PFKL PFKL Carbohydrate Metabolism - fructose and mannose; Carbohydrate Metabolism - galactose; Carbohydrate Metabolism - glycolysis and gluconeogenesis; Carbohydrate Metabolism - pentose phosphate pathway; EC 2.7.1.11; Kinase, other P17858 5211 21q22.3 human K689-ac 14367386 AMLWLSEkLREVYRK molecular association, regulation; intracellular localization FBPase(INDUCES) 28424264 1 1 0 regulates formation of multienzyme metabolic complexes +AR AR DNA-binding; Nuclear receptor; Transcription factor P10275 367 Xq12 human S293-p 15605001 PLAECKGsLLDDSAG Androgen_recep activity, induced; molecular association, regulation transcription, altered; cell growth, altered DNA(NOT_REPORTED) 20713353 1 0 0 +Gata1 GATA1 DNA-binding; Transcription factor P17679 14460 X A1.1|X 3.59 cM mouse K246-ac 459077 RPLIRPKkRMIVSKR protein degradation; acetylation; ubiquitination; phosphorylation cell differentiation, induced DNA(INDUCES) 10207073; 16858405 4 0 0 +MET Met EC 2.7.10.1; KINASE; Kinase, protein; Membrane protein, integral; Oncoprotein; Protein kinase, TK; Protein kinase, tyrosine (receptor) P08581 4233 7q31.2 human Y1003-p 448469 VSNESVDyRATFPED activity, induced; protein degradation; protein stabilization; molecular association, regulation; ubiquitination; receptor desensitization, altered; enzymatic activity, induced carcinogenesis, inhibited; cell growth, inhibited; apoptosis, induced; cell motility, induced; cell motility, inhibited; signaling pathway regulation; cell growth, altered Cbl-c(INDUCES); PTP1B(INDUCES); PTPN2(INDUCES); CBL(INDUCES) 11741535; 18819921; 19450681; 24634221; 36268649 16 26 366 +IRX2 IRX2 DNA-binding; Transcription factor Q9PU52 373975 chicken S46-p 452191 SSSGSAFsPYPGSAA transcription, altered 15133517 1 0 0 +PDPK1 PDK1 EC 2.7.11.1; KINASE; Kinase, protein; Nuclear receptor co-regulator; Protein kinase, AGC; Protein kinase, Ser/Thr (non-receptor) O15530 5170 16p13.3 human Y373-p 447694 SEDDEDCyGNYDNLL enzymatic activity, induced apoptosis, altered 11481331; 20044479; 20643654 9 1 0 +Olig2 OLIG2 Oncoprotein; Transcription factor Q9EQW6 50913 16 C3.3|16 52.6 cM mouse S147-p 18357904 GPSVRKLsKIATLLL HLH molecular association, regulation cell differentiation, inhibited; cell differentiation, altered; transcription, inhibited HSPA9B(DISRUPTS); neurogenin 2(DISRUPTS); PARP1(DISRUPTS); OLIG2(INDUCES); HSC70(DISRUPTS) 21382552; 36241911 2 0 0 +MAP4K1 HPK1 EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, STE; Protein kinase, Ser/Thr (non-receptor) Q92918 11184 19q13.2 human S171-p 455474 ATLARRLsFIGTPYW Pkinase protein degradation; enzymatic activity, induced transcription, altered 15743830; 24362026 3 1 13 +PTH PTH Apoptosis; Hormone; Secreted; Secreted, signal peptide P01270 5741 11p15.3 human S32-p 23135902 GKSVKKRsVSEIQLM Parathyroid molecular association, regulation signaling pathway regulation PTHR(INDUCES) 25158085 1 1 11 +CTH CTH Amino Acid Metabolism - cysteine and methionine; Amino Acid Metabolism - glycine, serine and threonine; Cell cycle regulation; EC 4.4.1.1; Energy Metabolism - nitrogen; Lyase; Other Amino Acids Metabolism - selenoamino acid P32929 1491 1p31.1 human K73-ub 3937199 PTRNCLEkAVAALDG Cys_Met_Meta_PP protein degradation 32755037 1 4 1 +DVL2 DVL2 Adaptor/scaffold; Motility/polarity/chemotaxis O14641 1856 17p13.1 human S418-p 56649827 GCEGRGLsVHTDMAS molecular association, regulation; protein conformation transcription, induced; signaling pathway regulation DVL2(INDUCES) 34155117 1 1 0 regulates Wnt Signaling +Bcl2l1 Bcl-xL Apoptosis; Autophagy; Membrane protein, integral; Mitochondrial P53563 24888 3q41 rat S228-p 5014912 AGVVLLGsLFSRK__ apoptosis, altered 18951975 1 0 0 +TRIM28 TIF1B EC 6.3.2.-; KINASE; Kinase, protein; Ligase; Nuclear receptor co-regulator; Protein kinase, atypical; SUMO LIGASE; SUMO ligase; Transcription, coactivator/corepressor; UBIQUITIN LIGASE; Ubiquitin conjugating system; Ubiquitin ligase Q13263 10155 19q13.43 human S823-p 471281 SLPGAGLsSQELSGG phosphorylation 37438603 2 2 3 induces phosphorylation of S824 +TP53 p53 Activator; DNA-binding; Motility/polarity/chemotaxis; Nuclear receptor co-regulator; Transcription factor; Tumor suppressor P04637 7157 17p13.1 human T81-p 447540 APAPAAPtPAAPAPA protein degradation; acetylation; molecular association, regulation; protein stabilization cell cycle regulation; carcinogenesis, induced; cell growth, induced; apoptosis, induced; transcription, induced; transcription, altered MDM2(DISRUPTS); PIN1(INDUCES); PPP1R13L(DISRUPTS) DNA(INDUCES) 11283254; 12397361; 12397362; 17906639; 27147566; 33745968 11 1 1 +Ank3 ANK3 iso4 Adaptor/scaffold; Motility/polarity/chemotaxis XP_006513193 11735 10 B5.3|10 36.1 cM mouse S2619-p 15718933 SQSSTSSsPEKVLTE molecular association, regulation; protein conformation neural plasticity; signaling pathway regulation SPTBN4(INDUCES) 31451636 1 2 0 targeting of SPTBN4 into the palasma membrane is reduced in S1982A mutatnt +REL REL Oncoprotein; Transcription factor Q04864 5966 2p16.1 human S557-p 480318 SNTTVFVsQSDAFEG transcription, altered 17072339 1 0 0 +Runx2 AML3 iso5 DNA-binding; Transcription factor Q08775-5 12393 17 B3|17 21.33 cM mouse S125-p 460037 AELVRTDsPNFLCSV Runt activity, inhibited transcription, inhibited 23918955 4 2 0 +ABI1 Abi-1 Adaptor/scaffold; Motility/polarity/chemotaxis Q8IZP0 10006 10p12.1 human S267-p 18715503 PIAVPTPsPPTIGPE molecular association, regulation cell motility, altered; cytoskeletal reorganization 21419341 1 0 1 regulates WRC (WAVE2 regulatory complex) interaction with Arp2/3 and lamellipodial protrusion +PIK3R2 PIK3R2 Kinase, lipid; Motility/polarity/chemotaxis O00459 5296 19p13.11 human K541-sm 56709100 EIHESRTkLEQQLRA PI3K_P85_iSH2 phosphorylation carcinogenesis, inhibited; signaling pathway regulation 26411363 1 0 0 sumolation inhibits PI3KR2 phosphorylation, regulates PI3K pathway activation +Mitf MITF iso8 DNA-binding; Oncoprotein; Transcription factor Q08874-8 17342 6 D3|6 45.05 cM mouse S409-p 450265 KTSSRRSsMSAEETE DUF3371 molecular association, regulation; intracellular localization transcription, induced; transcription, altered PIAS3(DISRUPTS) 14645519; 15572665 8 5 0 +PIK3C3 PIK3C3 Autophagy; Carbohydrate Metabolism - inositol phosphate; EC 2.7.1.137; Kinase, lipid; Motility/polarity/chemotaxis Q8NEB9 5289 18q12.3 human T159-p 14659500 DGSEPTKtPGRTSST PI3K_C2 molecular association, regulation; enzymatic activity, inhibited endocytosis, altered beclin 1(DISRUPTS) 20513426 2 0 0 inhibits autophagy +Pxn PXN Adaptor/scaffold; Cell adhesion; Cytoskeletal; Motility/polarity/chemotaxis Q66H76 360820 12q16 rat Y118-p 448604 AGEEEHVySFPNKQK Paxillin activity, induced; molecular association, regulation; intracellular localization cell motility, altered DOCK1(INDUCES); CRK(INDUCES) 15308668; 21357465 83 79 2519 activation of Rac1; colocalized in glucose induced filipodia extensions, leading to insulin secretion +BHLHE41 BHLHB3 Q9C0J9 79365 12p12.1 human K210-sm 31094507 CLERAGQkLEPLAYC molecular association, regulation; methylation cell differentiation, inhibited; chromatin organization, altered; transcription, inhibited EHMT2(INDUCES) 23637228 1 0 0 induces histone dimethylation, induces recruitment of EHMT2 to promoters through binding to EHMT2 +Rb1 Rb Nuclear receptor co-regulator; Oncoprotein; Transcription, coactivator/corepressor; Tumor suppressor P13405 19645 14 38.73 cM|14 D3 mouse S601-p 447976 TAADMYLsPLRSPKK molecular association, regulation cell cycle regulation; cell growth, induced; transcription, inhibited E2F1(DISRUPTS) 10207050; 35023164; 9671466 13 10 30 transcriptional downregulation of the E2F-1, E2F-2, dihydrofolate reductase, thymidine kinase, c-myc, proliferating-cell nuclear antigen, p107, and p21/Cip1 genes +SLC6A3 DAT Membrane protein, integral; Membrane protein, multi-pass; Transporter; Transporter, SLC family Q01959 6531 5p15.33 human S12-p 451137 KCSVGLMsSVVAPAK activity, induced 15024426; 16908408 6 0 0 stimulates DAT-mediated efflux of dopamine +HSP90AA1 HSP90A Chaperone; Heat shock protein P07900 3320 14q32.31 human K69-ac 2884401 ESLTDPSkLDSGKEL HATPase_c molecular association, regulation; intracellular localization carcinogenesis, induced; exocytosis, induced CHIP(DISRUPTS); HSP70(DISRUPTS); MMP2(INDUCES) 18559531; 18660379 3 4 4 +NME3 NME3 Apoptosis; EC 2.7.4.6; Kinase, nucleoside diphosphate; Kinase, other; Motility/polarity/chemotaxis; Nucleotide Metabolism - purine; Nucleotide Metabolism - pyrimidine Q13232 4832 16p13.3 human S61-p 3137800 ALKLVQAsEELLREH NDK molecular association, regulation cell differentiation, altered NME1(INDUCES) 11042679 1 0 0 +LMNA lamin A/C Cytoskeletal P02545 4000 1q22 human S22-p 452604 QASSTPLsPTRITRL activity, induced; molecular association, regulation; intracellular localization cell cycle regulation; cytoskeletal reorganization lamin A/C(DISRUPTS) 18815303; 19165338; 24582498; 24741066; 31511386; 34806324; 35839855; 36695453; 7925482 18 96 129 dominant negative mitotic affects, and mitotic assembly and disassembly of lamin +FLNA FLNA Actin-binding; Motility/polarity/chemotaxis; Nuclear receptor co-regulator P21333 2316 Xq28 human S1084-p 452265 LQGGSAGsPARFTID Filamin cell motility, induced; cytoskeletal reorganization 25445790 1 73 4 cell separation following mitosis, AAA mutant has defects in cell motility +ARX ARX Cancer Testis Antigen (CTA); DNA-binding Q96QS3 170302 Xp21.3 human S174-p 1297351802 VSISRSKsYRENGAP activity, induced; molecular association, regulation; intracellular localization transcription, induced PICK1(INDUCES) 30419043 1 1 0 +RUNX1 AML1 iso8 DNA-binding; Oncoprotein; Transcription factor Q01196-8 861 21q22.12 human S303-p 454401 VHPATPIsPGRASGM activity, induced; protein degradation; molecular association, regulation; phosphorylation cell differentiation, induced; cell growth, induced; transcription, induced; cell growth, altered HDAC1(DISRUPTS); HDAC3(DISRUPTS) 16046550; 17015473; 18003885; 21059642; 22531928 13 11 70 +GRAP2 GADS Adaptor/scaffold O75791 9402 22q13.1 human T262-p 451895 ALMHRRHtDPVQLQA intracellular localization; activity, inhibited; phosphorylation 25452106 2 16 142 PLC-gamma phosphorylation. Gads functions as a regulated modulator of cellular signaling to TCR signaling +DENND3 DENND3 GEF; GEF, Rab A2RUS2 22898 8q24.3 human S490-p 23050193 ELAPRNSsLRLTDTA molecular association, regulation 14-3-3 beta(INDUCES) 25925668 2 3 3 enhances its GEF activity toward Rab12 +ASIC1 ASIC1 Channel, cation; Membrane protein, integral; Membrane protein, multi-pass; Transporter; Transporter, ion channel P78348 41 12q13.12 human S40-p 6057800 IFSYERLsLKRALWA ASC activity, inhibited 19091960 1 0 0 +BAIAP2L1 IRTKS Adaptor/scaffold; Cytoskeletal Q9UHR4 55971 7q21.3-q22.1 human Y37-p 21336505 LINLGKNyEKAVNAM IMD cell motility, induced 21840312 1 0 0 +Gata1 GATA1 DNA-binding; Transcription factor P17679 14460 X A1.1|X 3.59 cM mouse K252-ac 459078 KKRMIVSkRAGTQCT protein degradation; acetylation; ubiquitination; phosphorylation DNA(INDUCES) 16858405 2 0 0 Phosphorylation and acetylation cause the degradation of acetylated GATA-1; acetylation of GATA-1 causes ubiquitination; DNA binding is required for MAPK-dependent phosphorylation +SOX2 SOX2 Cell development/differentiation; DNA-binding; Transcription factor P48431 6657 3q26.33 human S249-p 6738004 SVVKSEAsSSPPVVT molecular association, regulation cell cycle regulation; cell differentiation, induced Oct4(INDUCES) RNA(INDUCES) 34497381 1 5 0 +KDM4B JMJD2B DEMETHYLASE; Demethylase; EC 1.14.11.-; Oxidoreductase O94953 23030 19p13.3 human K562-ub 31914120 AQKGPTWkEPVSPME protein degradation 23589305 1 2 0 +Ncoa1 SRC-1 ACETYLTRANSFERASE; Acetyltransferase; DNA-binding; EC 2.3.1.48; Nuclear receptor co-regulator; Oncoprotein; Transcription, coactivator/corepressor P70365 17977 12|12 A1.1 mouse S1272-p 396518804 PVPPPQSsLLQQTPP DUF1518 molecular association, regulation cell differentiation, induced; transcription, induced RORC(INDUCES) 29282318 1 1 0 +MPL MPL Membrane protein, integral; Receptor, cytokine P40238 4352 1p34.2 human K553-ub 11956704 TAALSPPkATVSDTC protein degradation cell growth, inhibited 19880496 1 0 0 +GRK1 GRK1 EC 2.7.11.14; KINASE; Kinase, protein; Protein kinase, AGC; Protein kinase, Ser/Thr (non-receptor) P28327 281457 cow T489-p 2530400 QDVGAFStVKGVAFE molecular association, regulation; enzymatic activity, inhibited PTN(DISRUPTS) 7797516 3 1 0 +STK39 STLK3 EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, STE; Protein kinase, Ser/Thr (non-receptor) Q9UEW8 27347 2q24.3 human S309-p 450930 MMKKYGKsFRKLLSL Pkinase enzymatic activity, induced 14988727 1 0 0 +KIF2B KIF2B Microtubule-binding; Motor Q8N4N8 84643 17q22 human S617-p 25247530 TISGKGSsQWLENIQ intracellular localization cell cycle regulation 22535524 1 1 0 +NR3C2 MCR DNA-binding; Nuclear receptor P08235 4306 4q31.23 human S361-p 25692903 TLRDVVPsPDTQEKG protein degradation; ubiquitination transcription, inhibited 22798426 1 2 0 +MAP1LC3A LC3A Autophagy; Microtubule-binding; Ubiquitin-like modifier; Vesicle Q9H492 84557 20q11.22 human K51-ac 36293441 LPVLDKTkFLVPDHV ATG8 molecular association, regulation; intracellular localization autophagy, inhibited DOR-1(DISRUPTS); ATG7(DISRUPTS) 25601754 1 1 0 +KDM4B JMJD2B DEMETHYLASE; Demethylase; EC 1.14.11.-; Oxidoreductase O94953 23030 19p13.3 human S566-p 452590 PTWKEPVsPMELTGP protein stabilization; ubiquitination 28945223 1 14 0 +TGFBR2 TGFBR2 EC 2.7.11.30; KINASE; Kinase, protein; Membrane protein, integral; Oncoprotein; Protein kinase, Ser/Thr (receptor); Protein kinase, TKL P37173 7048 3p24.1 human S416-p 452049 SVDDLANsGQVGTAR PK_Tyr_Ser-Thr enzymatic activity, inhibited 9155023 1 0 0 +SYT4 SYT4 Calcium-binding; Membrane protein, integral; Vesicle Q9H2B2 6860 18q12.3 human S135-p 4706863 EGEKESVsPESLKSS intracellular localization exocytosis, induced 18046461 2 5 0 +Alyref2 Refbp2 DNA-binding; RNA-binding Q9JJW6 56009 1|1 H3 mouse R171-m1 13906410 GNRGGMTrSRGSGGF FoP_duplication molecular association, regulation RNA(DISRUPTS) 20129943 1 1 0 +Src Src iso1 EC 2.7.10.2; KINASE; Kinase, protein; Oncoprotein; Protein kinase, TK; Protein kinase, tyrosine (non-receptor) P05480-1 20779 2 H1|2 78.35 cM mouse Y221-p 448233 KLDSGGFyITSRTQF SH2 molecular association, regulation GRB2(INDUCES) 11713208 8 3 21 +Kcne2 KCNE2 Membrane protein, integral P63161 171138 11q11 rat S98-p 486280 DWQQKYRsQILHLED ISK_Channel protein degradation 22180649 2 0 0 causes degradation of hERG and reduces its current amplitude and its surface localization +Relb RELB Transcription factor Q04863 19698 7 A3|7 9.93 cM mouse K305-ub 3055601 ELYLLCDkVQKEDIS RHD_dimer transcription, induced 18620544 1 1 0 +SHB SHB Adaptor/scaffold Q15464 6461 9p13.1 human Y246-p 450867 KVTIADDySDPFDAK molecular association, regulation cell motility, induced; signaling pathway regulation RASA1(INDUCES) 32060095 1 28 528 regulates EphB2 signaling +BUB1B BUB1B EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, Other; Protein kinase, Ser/Thr (non-receptor); Tumor suppressor O60566 701 15q15.1 human K250-sm 25174702 IRVGGALkAPSQNRG protein degradation cell cycle regulation 22167194 1 0 0 +Kif3a KIF3A Microtubule-binding; Motor P28741 16568 11 B1.3|11 31.97 cM mouse S689-p 454304 KMGRRKRsAKPETVI activity, induced; molecular association, regulation CDH2(INDUCES) 26335646 3 28 2 enhances N-cadhedrin transport and affects synapse formation +CNN1 calponin 1 Actin-binding; Contractile; Motility/polarity/chemotaxis; Myosin-binding P26932 396522 chicken T170-p 469593 IIGLQMGtNKFASQQ Calponin molecular association, regulation ACTA1(DISRUPTS) 10873572 2 0 0 f-actin (rabbit skeletal muscle) shown by co-sedimentation +STK38 NDR1 EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, AGC; Protein kinase, Ser/Thr (non-receptor) Q15208 11329 6p21.31 human S6-p 22553318 __MAMTGsTPCSSMS enzymatic activity, inhibited; phosphorylation signaling pathway regulation 22142472 1 0 0 induces JNK phosphorylation, regulates cell death through JNK signaling +DLC1 DLC1 GAP; GAP, Rac/Rho; Tumor suppressor Q96QB1 10395 8p22 human T738-p 17434624 KRSVSNStQTSSSSS activity, induced; molecular association, regulation; phosphorylation cell motility, inhibited 25525271 1 1 1 Phosphorylation at T738 and S745 is essential for DLC1-PP2A binding and dephosphorylation +SARS1 SARS Aminoacyl-tRNA synthetase; EC 6.1.1.11; Ligase; RNA processing; Translation; Translation regulation P49591 6301 1p13.3 human S101-p 23141783 ALANLKVsQIKKVRL Seryl_tRNA_N molecular association, regulation carcinogenesis, induced; cell growth, induced; transcription, induced DNA(DISRUPTS) 33351793 1 0 1 +RAD21 RAD21 O60216 5885 8q24.11 human K216-sm 610821404 LEYEDQYkDDNFGEG DNA repair, induced 22751501 1 1 0 +Atp1a1 ATP1A1 EC 3.6.3.9; Hydrolase; Membrane protein, integral; Membrane protein, multi-pass; Transporter; Transporter, ion channel P06685 24211 2q34 rat S23-p 449087 SEHGDKKsKKAKKER protein degradation; receptor internalization, induced; molecular association, regulation; enzymatic activity, inhibited; intracellular localization; protein conformation; enzymatic activity, induced endocytosis, induced 14-3-3 beta(INDUCES); AP2A1(INDUCES) 10933807; 12466249; 12482133; 12671055; 12759348; 15030374; 15722354; 17065225; 19286978; 27605582; 9890946 21 1 0 There may be other phoshorylation and ubiquitylation sites involved. +ANGPTL8 EG624219 Secreted; Secreted, signal peptide Q6UXH0 55908 19p13.2 human T98-p 1869062302 LRASLLEtQMEEDIL phosphorylation 32344005 1 0 0 enhances Akt phosphorylation, regulates signaling pathway AKT-GSK3 ?/-FoxO1 through Akt phosphorylation +KIF14 KIF14 Microtubule-binding; Motor Q15058 9928 1q32.1 human S56-p 31882103 NDDPLLRsAGKVRDI intracellular localization 28630147 1 2 0 spindle localization of Kif14 in anaphase +AIFM1 PDCD8 Apoptosis; EC 1.-.-.-; Mitochondrial; Oxidoreductase O95831 9131 Xq26.1 human S116-p 27455805 KQKKAALsASEGEEV apoptosis, inhibited 29255269 2 9 0 oxeiptosis +XRCC6 Ku70 DNA repair, damage; DNA-binding; EC 3.6.4.-; EC 4.2.99.-; Helicase; Nuclear receptor co-regulator; RNA-binding P12956 2547 22q13.2 human S27-p 449267 QEENLEAsGDYKYSG molecular association, regulation; intracellular localization cell cycle regulation; DNA repair, induced; chromatin organization, altered; DNA repair, altered; apoptosis, inhibited UBE2M(DISRUPTS); UBE2A(INDUCES); RIF1(INDUCES); N4BP1(INDUCES); POLR2F(INDUCES); UBE2G2(INDUCES); TIF1G(INDUCES) DNA(DISRUPTS) 26337656; 34718776 2 14 0 +CBX1 CBX1 Transcription factor P83916 10951 17q21.32 human T51-p 2753801 GFSDEDNtWEPEENL Chromo molecular association, regulation; intracellular localization H3(DISRUPTS) DNA(DISRUPTS) 18438399; 19657222 2 0 0 +Crebbp CBP ACETYLTRANSFERASE; Acetyltransferase; DNA-binding; EC 2.3.1.48; Motility/polarity/chemotaxis; Nuclear receptor co-regulator; Transcription, coactivator/corepressor P45481 12914 16 A1|16 2.4 cM mouse K1034-sm 3726903 LQGSSQVkEETDTTE molecular association, regulation transcription, inhibited DAXX(INDUCES); HDAC2(INDUCES) 16287980 1 1 0 +Mapt Tau ACETYLTRANSFERASE; Acetyltransferase; Cytoskeletal P19332 29477 10q32.1 rat T542-p 449079 KKVAVVRtPPKSPSA neural plasticity; cytoskeletal reorganization 18245083; 33768378 149 48 14 +Cited1 CITED1 Nuclear receptor co-regulator P97769 12705 X D|X 45.25 cM mouse S80-p 27937108 SPTATPSsKPPSFNL CITED intracellular localization cell differentiation, induced 23529225 1 0 0 S63/64/65/67/69/73/79/80/84A mutation in CITED1 inhibits its translocation into the nucleus and osteoblasts differentiation +PXN PXN Adaptor/scaffold; Cell adhesion; Cytoskeletal; Motility/polarity/chemotaxis P49024 395832 chicken S273-p 465466 ELDELMAsLSDFKFM molecular association, regulation; protein conformation cell motility, altered FAK(DISRUPTS) 18092823 12 12 0 +HK2 HK2 Carbohydrate Metabolism - amino sugar and nucleotide sugar; Carbohydrate Metabolism - fructose and mannose; Carbohydrate Metabolism - galactose; Carbohydrate Metabolism - glycolysis and gluconeogenesis; Carbohydrate Metabolism - starch and sucrose; EC 2.7.1.1; Kinase, other; Mitochondrial P52789 3099 2p12 human K492-sm 1881215705 LEVKRRMkVEMERGL carcinogenesis, inhibited; cell growth, inhibited 33753739 1 0 0 SUMO-defective HK2 contributes to prostate cancer cell proliferation and tumorigenesis +PKMYT1 Myt1 EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, Other; Protein kinase, Ser/Thr (non-receptor); Protein kinase, dual-specificity (non-receptor) Q99640 9088 16p13.3 human S441-p 11331000 DSLGPSLsPEAVLAR molecular association, regulation PIN1(INDUCES) 10504341 1 0 0 +CDCP1 CDCP1 Cell surface; Membrane protein, integral Q9H5V8 64866 3p21.31 human Y743-p 455578 VIEDTMVyGHLLQDS molecular association, regulation cell growth, induced SHP-2(INDUCES) 23300860; 25876044 3 0 3 +CCNY CBCP1 Cell cycle regulation Q8ND76 219771 10p11.21 human S326-p 453488 SARKRSAsADNLTLP molecular association, regulation; phosphorylation autophagy, induced 14-3-3 zeta(INDUCES); CDK16(INDUCES) 26205494; 32098961 2 93 52 induces phosphorylation at S336 +Atg13 ATG13 Autophagy; Vesicle Q91YI1 51897 2|2 E1 mouse S354-p 21127300 DTETVSNsSEGRASP carcinogenesis, induced; autophagy, induced; cell growth, induced 35246531 18 5 0 +MCRS1 MCRS1 Nuclear receptor co-regulator; Nucleolus; RNA-binding Q96EZ8 10445 12q13.12 human S36-p 40268168 AGQKRASsQALGTIP cell cycle regulation; cytoskeletal reorganization 27192185 1 2 0 K-fiber formation and dynamics +Sharpin SHARPIN Apoptosis Q91WA6 106025 15 D3|15 35.75 cM mouse K42-ub 54221302 DAEAQPRkLQLIADP Sharpin_PH signaling pathway regulation 26829767 1 1 0 regulation of TCR signaling-maintenance of immuno; ogical signaling K63-linked polyubiquitination +ERRFI1 MIG-6 Inhibitor; Tumor suppressor Q9UJM3 54206 1p36.23 human Y394-p 451607 KKVSSTHyYLLPERP molecular association, regulation EGFR(INDUCES) 26967626; 32574989 4 17 253 +Nherf1 NHERF Adaptor/scaffold; Motility/polarity/chemotaxis P70441 26941 11|11 E2 mouse S77-p 957200 ETHQQVVsRIRAALN PDZ molecular association, regulation SLC34A1(DISRUPTS) 17975671; 20200151 4 0 0 +ACE2 ACE2 EC 3.4.17.23; Membrane protein, integral; Protease Q9BYF1 59272 Xp22.2 human K114-ub 1880091003 VLSEDKSkRLNTILN Peptidase_M2 protein degradation 35894122 1 1 0 +HDAC3 HDAC3 Apoptosis; Cell cycle regulation; DEACETYLASE; Deacetylase; EC 3.5.1.98; Nuclear receptor co-regulator; Transcription, coactivator/corepressor O15379 8841 5q31.3 human Y328-p 1267669101 EELPYSEyFEYFAPD activity, induced; intracellular localization; enzymatic activity, induced carcinogenesis, induced; cell growth, induced 30317579; 31430896 2 0 0 +PRKCB PKCB EC 2.7.11.13; KINASE; Kinase, protein; Motility/polarity/chemotaxis; Protein kinase, AGC; Protein kinase, Ser/Thr (non-receptor) P05771 5579 16p12.2-p12.1 human T642-p 447897 TRQPVELtPTDKLFI Pkinase_C molecular association, regulation; intracellular localization; enzymatic activity, induced CLTA(INDUCES) 17504762; 36717249 14 14 0 +XRCC1 XRCC1 DNA repair, damage P18887 7515 19q13.31 human T367-p 36131476 LICAFANtPKYSQVL BRCT intracellular localization DNA repair, induced 28740101 1 2 0 recruitment of XRCC1 to DNA damage and binding to PARP1/PAR +NUP98 NUP98 iso2 Motility/polarity/chemotaxis; Nucleoporin P52948-2 4928 11p15.4 human S494-p 18330803 HINSLTYsPFGDSPL intracellular localization 21335236 1 1 1 as multiple sites (13PM) mutant +Ikzf1 Ikaros C2H2-type zinc finger protein; DNA-binding; Transcription factor Q03267 22778 11 A1|11 7.02 cM mouse T23-p 4828303 ESPPVSDtPDEGDEP molecular association, regulation; intracellular localization DNA(DISRUPTS) 18223295 1 0 0 +MAP4 MAP4 Cytoskeletal; Motility/polarity/chemotaxis P27816 4134 3p21.31 human K852-ac 62495522 EVKKMTAkSVPADLS cytoskeletal reorganization 28002468 1 1 0 +CALD1 Caldesmon Actin-binding Q05682 800 7q33 human S759-p 448465 KTPDGNKsPAPKPSD Caldesmon molecular association, regulation; intracellular localization; protein conformation cell motility, altered; cytoskeletal reorganization ACTA1(DISRUPTS) 11983427; 16289153; 20128924 7 21 0 +Ctcf CTCF C2H2-type zinc finger protein; Transcription factor; Tumor suppressor Q61164 13018 8|8 D3 mouse K698-sm 6124704 ENIIVEVkKEPDAEP transcription, inhibited 19029252 2 3 0 +TGIF2 TGIF2 DNA-binding Q9GZN2 60436 20q11.23 human T186-p 25174055 LFNTPPPtPPEQDKE molecular association, regulation carcinogenesis, induced; cell motility, induced; transcription, altered HDAC1(INDUCES) DNA(INDUCES) 36647029 1 5 0 +Kcna2 Kv1.2 Channel, potassium; Membrane protein, integral; Membrane protein, multi-pass P63142 25468 2q34 rat Y458-p 19083401 STISKSDyMEIQEGV activity, induced; molecular association, regulation signaling pathway regulation MBP(INDUCES); CNTN2(INDUCES) 21602278 1 0 0 +CGAS cGAS EC 2.7.7.86 Q8N884 115004 6q13 human Y215-p 1271626200 LLNTGSYyEHVKISA Mab-21 molecular association, regulation; enzymatic activity, inhibited; intracellular localization DNA repair, induced; chromatin organization, altered; DNA repair, inhibited DNA(DISRUPTS) 30356214; 31544964 2 0 0 +ZRANB1 ZRANB1 DEUBIQUITINASE; EC 3.4.19.12; Ligase; Protease; Ubiquitin conjugating system; Ubiquitin-specific protease Q9UGI0 54764 10q26.13 human S78-p 1105513501 SARPRVKsSYSMENA enzymatic activity, induced 29748601 1 1 0 phosphorylation induced by AKT induces K63 deubiquitinating activity toward Twist1 +HCFC1 HCFC1 Transcription, coactivator/corepressor P51610 3054 Xq28 human K1808-ub 6423510 PSKAPMKkENQWFDV protein stabilization cell cycle regulation; cell growth, induced 19188440 1 3 0 +CDC73 CDC73 Cell cycle regulation; Tumor suppressor Q6P1J9 79577 1q31.2 human S465-p 1879768900 PWLLPDGsPVDIFAK protein stabilization 35551175 1 0 0 +Hnf4a HNF4 alpha DNA-binding; Nuclear receptor; Transcription factor P49698 15378 2 H3|2 84.32 cM mouse Y286-p 22996302 LQIDDNEyACLKAII Hormone_recep molecular association, regulation SSU72(INDUCES) 34616001 2 1 0 +DLC1 DLC1 GAP; GAP, Rac/Rho; Tumor suppressor Q96QB1 10395 8p22 human S557-p 37038503 LEEFDVFsPKQDLVP activity, induced; intracellular localization; protein conformation carcinogenesis, inhibited; cell growth, inhibited; cell motility, inhibited talin 1(INDUCES); tensin 1 iso1(INDUCES) 25452387 1 1 0 localize to focal adhesions; activates Rho-GAP activity +NCOA1 SRC-1 ACETYLTRANSFERASE; Acetyltransferase; DNA-binding; EC 2.3.1.48; Nuclear receptor co-regulator; Oncoprotein; Transcription, coactivator/corepressor Q15788 8648 2p23.3 human K732-sm 2407403 VQGNSSIkLELDASK intracellular localization transcription, induced PR(INDUCES) 12529333 1 0 0 +OSBP OSBP Lipid-binding P16258 rabbit S384-p 468342 KRTGSNIsGASSDIS phosphorylation 11441133 2 54 1 S381 promotes subsequent phosphorylation of serines 384 and 387 +OTUD6A OTUD6A DEUBIQUITINASE; EC 3.4.19.12; Ubiquitin-specific protease Q7L8S5 139562 Xq13.1 human S74-p 40512708 QDDSSIEsVVEDLAK molecular association, regulation; intracellular localization cell cycle regulation; carcinogenesis, induced TOPBP1(DISRUPTS) 35768646 1 3 0 +SNAI2 Snail2 Apoptosis; C2H2-type zinc finger protein; Motility/polarity/chemotaxis; Transcription factor O43623 6591 8q11.21 human S87-p 25525400 SSSLGRVsPPPPSDT cell motility, induced; transcription, induced 25855378 3 2 0 vimentin transcription +PTEN PTEN iso2 Carbohydrate Metabolism - inositol phosphate; EC 3.1.3.16; EC 3.1.3.48; EC 3.1.3.67; Motility/polarity/chemotaxis; Nuclear receptor co-regulator; PHOSPHATASE; Phosphatase, lipid; Tumor suppressor P60484-2 5728 10q23.31 human K235-ub 1877956800 RFLDSKHkNHYKIYN protein degradation 31685992 1 0 0 +GP1BB GPIbB Cell surface; Membrane protein, integral P13224 2812 22q11.21 human S191-p 456005 ARAAARLsLTDPLVA molecular association, regulation; receptor desensitization, altered cell adhesion, altered 14-3-3 zeta(INDUCES) 12361948; 9454760 5 15 1 +YAP1 YAP1 Oncoprotein; Transcription, coactivator/corepressor P46937 10413 11q22.1 human K497-ub 15400504 LAATKLDkESFLTWL activity, induced; protein degradation; ubiquitination; intracellular localization carcinogenesis, altered; cell motility, inhibited 29891922; 33939216; 36271031 3 2 5 +FMR1 FMR1 Nucleolus; RNA-binding; Translation Q06787 2332 Xq27.3 human S500-p 469583 NSEASNAsETESDHR FXMRP1_C_core molecular association, regulation neural plasticity; RNA stability, induced; cytoskeletal reorganization; translation, inhibited Other(DISRUPTS); RNA(INDUCES) 17376973; 22080836; 31112584; 36181660 21 6 0 inhibits binding to ribosomes; FMRP S500D binds PSD-95 mRNA and miR-125a +MAP4 MAP4 Cytoskeletal; Motility/polarity/chemotaxis P27816 4134 3p21.31 human K938-ac 62495523 DLKNVRSkVGSTENI Tubulin-binding cytoskeletal reorganization 28002468 1 1 0 +Irs1 IRS1 Adaptor/scaffold; Motility/polarity/chemotaxis P35570 25467 9q34 rat S332-p 455323 SDGEGTMsRPASVDG phosphorylation 15574412 2 1 0 decreases tyrosine phosphorylation of IRS-1 and Akt1 phosphorylation upon insulin stimulation +EP300 p300 ACETYLTRANSFERASE; Acetyltransferase; EC 2.3.1.48; Motility/polarity/chemotaxis; Nuclear receptor co-regulator; Transcription, coactivator/corepressor Q09472 2033 22q13.2 human K1020-sm 12063902 EERSTELkTEIKEEE molecular association, regulation transcription, inhibited HDAC6(INDUCES) 12718889 1 0 0 +Irak1bp1 IRAK1BP1 Transcription regulation Q9ESJ7 65099 9|9 E2 mouse T236-p 12524611 QQKIKSAtIHAASKV SIMPL intracellular localization transcription, altered 17079333 1 0 0 nuclear localization +Bmpr1a BMPR1A EC 2.7.11.30; KINASE; Kinase, protein; Membrane protein, integral; Protein kinase, Ser/Thr (receptor); Protein kinase, TKL P36895 12166 14 B|14 20.81 cM mouse Y467-p 25655001 MVPSDPSyEDMREVV PK_Tyr_Ser-Thr molecular association, regulation cell growth, induced; signaling pathway regulation BMPR2(INDUCES); TAB1(DISRUPTS) 22729085 1 1 0 regulation of BMP downstream pathways-Erk1/2 and Smad1 activation, regulates life span of osteoblasts (expansion) +FOXP2 FOXP2 C2H2-type zinc finger protein; DNA-binding O15409 93986 7q31.1 human S557-p 1147026601 NAVRHNLsLHKCFVR Forkhead molecular association, regulation; protein conformation transcription, altered DNA(DISRUPTS) 29845391 1 0 0 +PXN PXN Adaptor/scaffold; Cell adhesion; Cytoskeletal; Motility/polarity/chemotaxis P49024 395832 chicken S190-p 471383 VIPESSSsAGGKAAP Paxillin protein stabilization cell motility, altered 17121676 2 1 0 promotes cell spreading by increasing the dynamics of membrane protrusions +Gria3 GluR3 Channel, ligand-gated; Membrane protein, integral; Membrane protein, multi-pass Q9Z2W9 53623 X A4|X 23.19 cM mouse S885-p 456291 YNVYGTEsVKI____ neural plasticity 32071234 4 0 0 +VAV1 VAV1 GEF; GEF, Rac/Rho; Motility/polarity/chemotaxis; Oncoprotein P15498 7409 19p13.3 human Y826-p 450351 GWWRGEIyGRVGWFP SH3_1 activity, induced; molecular association, regulation carcinogenesis, altered; cell growth, altered CSK(INDUCES); Abl(INDUCES); SHC1(INDUCES); SH2D1A(INDUCES) 20457609 1 6 91 +HTT Huntingtin Cytoskeletal P42858 3064 4p16.3 human S430-p 2020881 LIAGGGSsCSPVLSR protein stabilization 22623107 1 6 4 reduced cell viability and enhanced protein accumulation in S430A mutant +Camkk1 CAMKK1 EC 2.7.11.17; KINASE; Kinase, protein; Protein kinase, Other; Protein kinase, Ser/Thr (non-receptor) P97756 60341 10q24 rat S74-p 452115 SLSARKFsLQERPAG molecular association, regulation; enzymatic activity, inhibited; phosphorylation 14-3-3 gamma(INDUCES); 14-3-3 eta(INDUCES) 15469938 4 19 8 binding of 14-3-3 leads to enzymatic inhibition and protection of CAMKK1 phospho-T108 +Clk2 CLK2 EC 2.7.12.1; KINASE; Kinase, protein; Protein kinase, CMGC; Protein kinase, dual-specificity (non-receptor) O35491 12748 3|3 F1 mouse S98-p 471940 YDTDFRQsYEYHREN protein degradation 20074525 1 6 5 +PRDX6 PRDX6 Amino Acid Metabolism - phenylalanine; EC 1.11.1.15; EC 1.11.1.9; Energy Metabolism - methane; Oxidoreductase; Phospholipase P30041 9588 1q25.1 human T177-p 3823356 TAEKRVAtPVDWKDG 1-cysPrx_C enzymatic activity, induced 19140803; 28055018 4 5 12 essential for optimum PLA2 activity; in vitro +TUBB1 TUBB1 Cytoskeletal; Motility/polarity/chemotaxis Q9H4B7 81027 20q13.32 human K252-ac 7807300 QLNADLRkLAVNMVP intracellular localization cytoskeletal reorganization 21177827 1 1 12 +ARAF ARAF EC 2.7.11.1; KINASE; Kinase, protein; Oncoprotein; Protein kinase, Ser/Thr (non-receptor); Protein kinase, TKL P10398 369 Xp11.3 human S262-p 3306309 RGSPSPAsVSSGRKS enzymatic activity, induced 18662992 1 2 0 +TP53 p53 Activator; DNA-binding; Motility/polarity/chemotaxis; Nuclear receptor co-regulator; Transcription factor; Tumor suppressor P04637 7157 17p13.1 human T377-p 3309800 KSKKGQStSRHKKLM molecular association, regulation; intracellular localization apoptosis, induced; transcription, induced; translation, induced S100B(DISRUPTS); S100A2(DISRUPTS) 19819244; 26384650; 27914807 5 0 0 nuclear accumulation, p21 transcription, cleaved PARP and cytotoxicity ; T304/377D p53 induces TNF-alpha mRNA, secretion of pro-in?ammatory cytokine TNF-alpha, and apoptosis +AKT1 Akt1 EC 2.7.11.1; KINASE; Kinase, protein; Oncoprotein; Protein kinase, AGC; Protein kinase, Ser/Thr (non-receptor) P31749 207 14q32.33 human K276-sm 31089528 NVVYRDLkLENLMLD Pkinase sumoylation; protein stabilization; intracellular localization; phosphorylation; enzymatic activity, induced neural plasticity; cell cycle regulation; carcinogenesis, induced; RNA splicing, induced; cell motility, induced; cell growth, induced; signaling pathway regulation 23884910; 24013425; 25867063; 34288124 4 1 0 Sumoylation at K64 and K276 increases T308 phosphorylation upregulates kinase activity.activates ERK-Elk-1Arc/BDNF and mTOR-P70S6k-4E-BP1 signaling, hippocampal LTP regulation; increases global sumoylation +Vim Vimentin Cytoskeletal; Motility/polarity/chemotaxis P31000 81818 17q12.3 rat S55-p 476052 TSRSLYSsSPGGAYV Filament_head cytoskeletal reorganization 12686602 4 23 30 Vimentin is phosphorylated during S55 during mitosis and is not affected by nestin. +KIF2C KIF2C Cancer Testis Antigen (CTA); Microtubule-binding; Motility/polarity/chemotaxis; Motor Q99661 11004 1p34.1 human S192-p 2132102 VNSVRRKsCLVKEVE intracellular localization; activity, inhibited cytoskeletal reorganization 14960279; 23055517 5 2 25 Inhibits its microtubule depolymerization activity +Etv4 ETV4 DNA-binding P28322 18612 11 D|11 65.48 cM mouse K38-ac 26373309 ALMVPQGkLMDPGSL ETS_PEA3_N sumoylation transcription, induced 21543453 1 1 0 acetylated sites inhibits sumoylation reciprocally +MAPT Tau iso8 ACETYLTRANSFERASE; Acetyltransferase; Cytoskeletal P10636-8 4137 17q21.31 human S400-p 449130 VYKSPVVsGDTSPRH molecular association, regulation Tau iso8(INDUCES) 15190058 13 44 70 polymerized into filaments when 4?6 mol of phosphate per mol of tau were incorporated +PGM1 PGM1 Carbohydrate Metabolism - amino sugar and nucleotide sugar; Carbohydrate Metabolism - galactose; Carbohydrate Metabolism - glycolysis and gluconeogenesis; Carbohydrate Metabolism - pentose phosphate pathway; Carbohydrate Metabolism - starch and sucrose; EC 5.4.2.2; Isomerase P36871 5236 1p31.3 human S117-p 2525691 GGIILTAsHNPGGPN PGM_PMM_I protein conformation; enzymatic activity, induced 25288802 0 69 6 initiation of catalysis by PGM1 is dependent on phosphoryl transfer from phosphoserine 117 +P2ry2 P2Y2 GPCR, family 1; Membrane protein, integral; Membrane protein, multi-pass; Receptor, GPCR; Receptor, misc. P41232 29597 1q32 rat T343-p 2909201 GLHRPNRtDTVRKDL receptor internalization, induced 31289122 2 0 0 Regulates ATP induced calcium response +MISP MISP Unknown function Q8IVT2 126353 19p13.3 human S575-p 459691 ALFPEVFsPTPDENS AKAP2_C molecular association, regulation ACTA1(DISRUPTS) 34023777 1 19 0 +Bcl2 Bcl-2 Apoptosis; Autophagy; Membrane protein, integral; Oncoprotein P10417 12043 1 E2.1|1 49.76 cM mouse T69-p 448398 HRDMAARtSPLRPLV protein stabilization; phosphorylation cell cycle regulation; autophagy, induced; apoptosis, inhibited 14660795; 32051584 11 0 0 induces AMPK, TBC1D1 phosphorylation +Ikzf1 Ikaros C2H2-type zinc finger protein; DNA-binding; Transcription factor Q03267 22778 11 A1|11 7.02 cM mouse S384-p 451349 VSSEREAsPSNSCQD activity, inhibited cell cycle regulation DNA(DISRUPTS) 15024069 1 3 2 +NUTM1 NUTM1 Unknown function Q86Y26 256646 15q14 human S1026-p 13165101 NFAYLLAsKLSLSPR NUT intracellular localization 17934517 1 0 0 nuclear-cytoplasmic shuttling +IFIH1 MDA5 Apoptosis; EC 3.6.4.13; Helicase Q9BYX4 64135 2q24.2 human S88-p 27807804 EALRRTGsPLAARYM CARD_2 molecular association, regulation; enzymatic activity, inhibited; activity, inhibited transcription, induced; transcription, inhibited; signaling pathway regulation IRF3(DISRUPTS); MAVS(DISRUPTS) RNA(INDUCES) 23499489; 28250012; 36113429 4 1 0 +Hdac4 HDAC4 DEACETYLASE; Deacetylase; EC 3.5.1.98; Hydrolase; Nuclear receptor co-regulator; SUMO LIGASE Q6NZM9 208727 1|1 D mouse S245-p 448488 FPLRKTAsEPNLKLR intracellular localization; enzymatic activity, inhibited transcription, altered 36477534; 36477539 13 24 25 +Zc3hav1 ZAP RNA-binding; Transferase Q8K3Y6 252832 4q22 rat S274-p 3203919 PLGSGPPsPDVTSCK activity, induced 22514281 1 40 12 +DOK1 DOK1 Adaptor/scaffold; Motility/polarity/chemotaxis Q99704 1796 2p13.1 human S439-p 454882 EPGTATGsGIKSHNS cell motility, induced; cell growth, inhibited 15574499 1 1 0 +GRB2 GRB2 Adaptor/scaffold; Cell development/differentiation; Motility/polarity/chemotaxis P62993 2885 17q25.1 human Y37-p 7388001 EECDQNWyKAELNGK SH3_1 cell growth, altered 19273609 1 0 0 regulates cell proliferation +Plk4 PLK4 EC 2.7.11.21; KINASE; Kinase, protein; Nucleolus; Protein kinase, Other; Protein kinase, Ser/Thr (non-receptor) Q64702 20873 3|3 B mouse S291-p 12654010 DSGHATLsTTITASS protein degradation; ubiquitination 20100909 2 1 0 +MAPK8 JNK1 EC 2.7.11.24; KINASE; Kinase, protein; Protein kinase, CMGC; Protein kinase, Ser/Thr (non-receptor) P45983 5599 10q11.22 human T183-p 447643 AGTSFMMtPYVVTRY Pkinase enzymatic activity, induced cell cycle regulation; carcinogenesis, induced; apoptosis, altered; carcinogenesis, inhibited; apoptosis, induced; cell motility, inhibited; transcription, induced; transcription, altered; signaling pathway regulation; cell differentiation, induced; cell growth, induced; cell adhesion, altered 10867021; 12368275; 15944157; 17210579; 28068431; 31575661; 33573023; 34034759; 34048499; 35154579; 35790913; 35843311; 36289618; 37298039; 8137421; 9312068 275 33 392 +NCOR1 N-CoR1 Nuclear receptor co-regulator; Transcription, coactivator/corepressor O75376 9611 17p12-p11.2 human S1450-p 1210494 TVRSRHTsVVSSGPS protein conformation transcription, induced 23940660 1 12 48 N-CoR misfolding, Flt3 derepression +LARS1 LARS Amino Acid Metabolism - valine, leucine and isoleucine biosynthesis; Aminoacyl-tRNA synthetase; EC 6.1.1.4; Ligase; Translation; Translation regulation Q9P2J5 51520 5q32 human T293-p 1345849602 NIFLVAAtLRPETMF tRNA-synt_1 molecular association, regulation; activity, inhibited autophagy, inhibited LC3B(INDUCES) 30411383 1 0 0 decreases LARS binding to leucine in the presence of isoleucine (activity inhibited) and as a result increases accumulation of misfolded proteins and ER stress; increases GRP78/BiP levels +SAMSN1 SAMSN1 Adaptor/scaffold Q9NSI8 64092 21q11.2 human S23-p 467324 QKPKRSSsFGNFDRF SLY molecular association, regulation; intracellular localization 14-3-3 beta(INDUCES); 14-3-3 gamma(INDUCES) 20478393 1 19 1 +IQGAP1 IQGAP1 GAP; GAP, Ras; Motility/polarity/chemotaxis P46940 8826 15q26.1 human S480-p 1869135500 NTVWKQLsSSVTGLT activity, induced carcinogenesis, induced; cell motility, induced; signaling pathway regulation 31431460 1 1 0 activates CDC4 and RAC1 +METTL3 METTL3 EC 2.1.1.62; METHYLTRANSFERASE; Methyltransferase; RNA processing Q86U44 56339 14q11.2 human S525-p 1871246003 YGMIERLsPGTRKIE MT-A70 protein stabilization; molecular association, regulation; ubiquitination; methylation carcinogenesis, induced; cell differentiation, induced; translation, induced USP5(DISRUPTS); PIN1(INDUCES) 33217317; 36755057 2 1 0 inhibits stabilization +Ctnnb1 CTNNB1 Actin-binding; Cell adhesion; Motility/polarity/chemotaxis; Nuclear receptor co-regulator; Oncoprotein; Transcription factor Q02248 12387 9 F4|9 72.19 cM mouse K49-ac 458938 TAPSLSGkGNPEEED transcription, inhibited 11973335 17 0 0 +Pitpnb PITPNB Lipid-binding P53811 56305 5|5 F mouse S165-p 451298 EDPALFHsVKTKRGP IP_trans activity, induced 11953429 1 0 0 +Mos MOS EC 2.7.11.1; KINASE; Kinase, protein; Oncoprotein; Protein kinase, Other; Protein kinase, Ser/Thr (non-receptor) P00536 17451 4 A1|4 2.16 cM mouse S232-p 450040 DLRCRQAsPHHIGGT Pkinase activity, inhibited 8622681 1 0 0 +PRKCI PKCI Cell adhesion; Cell development/differentiation; EC 2.7.11.13; KINASE; Kinase, protein; Motility/polarity/chemotaxis; Oncoprotein; Protein kinase, AGC; Protein kinase, Ser/Thr (non-receptor); Tumor suppressor P41743 5584 3q26.2 human Y430-p 482865 EILRGEDyGFSVDWW Pkinase protein conformation 17335005 1 0 0 +H3c1 H3 DNA-binding P68433 360198 13|13 A3.1 mouse K36-m1 465523 APATGGVkKPHRYRP Histone endocytosis, altered; cell adhesion, altered 33195484 17 19 47 axon guidance +GPSM3 GPSM3 G protein regulator, misc. Q9Y4H4 63940 6p21.32 human S39-p 4717970 PWRSAPPsPPPPGTR protein stabilization; molecular association, regulation; intracellular localization 14-3-3 beta(INDUCES) 22843681 1 27 9 +Ski SKI Cell cycle regulation; Oncoprotein; Transcription, coactivator/corepressor; Ubiquitin conjugating system XP_017449382 313757 rat S382-p 11145003 LSAFRPWsPAVSASE protein stabilization; molecular association, regulation; ubiquitination; intracellular localization autophagy, inhibited; transcription, inhibited RNF111(DISRUPTS) 34390788 3 10 7 inhibits ubiquitination +Esr1 ER-alpha DNA-binding; Nuclear receptor; Transcription factor P19785 13982 10 A1|10 2.03 cM mouse S171-p 448102 NGRERLSsSNEKGNM Oest_recep activity, induced cell differentiation, induced; transcription, induced 16585156; 28686577 48 6 0 +Axin1 axin 1 Adaptor/scaffold; Tumor suppressor O35625 12005 17 A3.3|17 13.07 cM mouse S157-p 27266401 LDSNGIVsRQTKPAT RGS molecular association, regulation cell cycle regulation TUBG1(DISRUPTS) 23155463 1 1 0 S157A mutant leads to an increased number of multi-centrosome containing mitotic cells; regulates centrosome duplication +SGTA SGTA Chaperone O43765 6449 19p13.3 human S305-p 479908 QIRSRTPsASNDDQQ molecular association, regulation PDGFRA(INDUCES) 20736484 1 60 567 +KLC1 KLC1 Microtubule-binding; Motor Q07866 3831 14q32.33 human S460-p 477826 YKACKVDsPTVTTTL protein processing 31806024 3 41 3 inhibits the axonal transport; promotes amyloidogenic processing of APP +ETV1 ETV1 DNA-binding; Oncoprotein; Transcription factor P50549 2115 7p21.2 human S94-p 3059606 KIKKEPHsPCSEISS ETS_PEA3_N activity, induced transcription, induced 12213813 2 0 0 +HIF1A HIF1A Autophagy; DNA-binding; Transcription factor Q16665 3091 14q23.2 human K21-ac 25126716 SSERRKEkSRDAARS protein degradation transcription, inhibited 21917920; 28319066 2 0 0 +SDCBP syntenin Adaptor/scaffold; Cell adhesion; Cytokine; Membrane protein, integral; Motility/polarity/chemotaxis; Vesicle O00560 6386 8q12.1 human Y4-p 23940700 ____MSLyPSLEDLK molecular association, regulation cell motility, induced; cytoskeletal reorganization MPRIP(INDUCES) 22349701 1 1 0 T-cell chemotaxis induced, Rac1 activation and translocation to plasma membrane induced +PRMT1 PRMT1 EC 2.1.1.125; METHYLTRANSFERASE; Methyltransferase; Methyltransferase, protein arginine; Nuclear receptor co-regulator Q99873 3276 19q13.33 human S307-p 10793949 GFSTSPEsPYTHWKQ methylation; enzymatic activity, induced apoptosis, induced; transcription, induced 31235809 2 5 3 +CHRM2 mAChR M2 GPCR, family 1; Membrane protein, integral; Membrane protein, multi-pass; Receptor, GPCR P08172 1129 7q33 human S311-p 459109 DENTVSTsLGHSKDE 7tm_1 receptor desensitization, altered; receptor internalization, altered 9162044 3 0 0 Mutation of 4 S/T to A eliminates receptor desensitization in response to carbachol treatment (as measured by isoproterenol-stimulated cAMP production after pretreatment with carbachol).; Mutation of S286 T287 S288 S290 to A caused a faster rate and a greater extent of receptor internalization after agonist stimulation (transients only, not observed in stables). Mutation of all 8 sites prevented internalization (in both transients and stables). +NPHS1 NPHS1 Cell adhesion; Immunoglobulin superfamily; Membrane protein, integral O60500 4868 19q13.12 human Y1193-p 469565 SGAWGPLyDEVQMGP molecular association, regulation; intracellular localization endocytosis, induced; exocytosis, induced; cell adhesion, induced; cytoskeletal reorganization; transcription, induced; endocytosis, inhibited NPHS2(INDUCES); ARRB2(DISRUPTS) 16968782; 22718751; 36822326 16 1 0 +Egfr EGFR EC 2.7.10.1; KINASE; Kinase, protein; Membrane protein, integral; Oncoprotein; Protein kinase, TK; Protein kinase, tyrosine (receptor) Q01279 13649 11 A2|11 9.41 cM mouse Y871-p 448061 LGAEEKEyHAEGGKV PK_Tyr_Ser-Thr carcinogenesis, induced; cell motility, induced; transcription, induced; signaling pathway regulation 18255094; 23652203; 36385375 97 20 171 +Gna11 G-alpha 11 G protein; G protein, heterotrimeric; G protein, heterotrimeric alpha G(q) P21278 14672 10 C1|10 39.72 cM mouse Y356-p 448561 LQLNLKEyNLV____ activity, induced 11994281; 9188537 2 0 2 +ZBTB33 Kaiso C2H2-type zinc finger protein; DNA-binding; Transcription factor Q86T24 10009 Xq24 human T606-p 34353150 YLSDRSStIPAMKDD molecular association, regulation carcinogenesis, inhibited; cell growth, inhibited; transcription, induced; cell motility, inhibited 14-3-3 sigma(INDUCES); 14-3-3 zeta(INDUCES); 14-3-3 epsilon(INDUCES); 14-3-3 gamma(INDUCES) 35851744 1 0 1 +CIC capicua DNA-binding; Transcription factor Q96RK0 23152 19q13.2 human S1409-p 453485 SAPEDPTsPKRKMRR molecular association, regulation; intracellular localization KPNA3(DISRUPTS) 21087211 1 31 25 +SCN5A SCN5A Channel, sodium; Membrane protein, integral; Membrane protein, multi-pass Q14524 6331 3p22.2 human S516-p 4719558 LSLTRGLsRTSMKPR Na_trans_cytopl methylation; activity, inhibited 22514276; 25501501 5 7 0 inhibits SCN5A methylation at R513 +USP16 USP16 DEUBIQUITINASE; EC 3.4.19.12; Protease; Ubiquitin conjugating system; Ubiquitin-specific protease Q9Y5T5 10600 21q21.3 human S330-p 29614602 ILKAFGNsTEKLDEE UCH enzymatic activity, induced 26323689 1 2 0 +FOXA1 FOXA1 DNA-binding; Transcription factor P55317 3169 14q21.1 human K267-ac 11263051 LRRQKRFkCEKQPGA molecular association, regulation chromatin organization, altered DNA(DISRUPTS) 19897491 1 0 0 +BMAL1 BMAL1 DNA-binding; Transcription factor O00327 406 11p15.3 human S78-p 3638466 KNAREAHsQIEKRRR HLH molecular association, regulation transcription, inhibited DNA(DISRUPTS) 23229515 2 0 1 regulates the circadian clock +SUGT1 SUGT1 Cell cycle regulation; Ubiquitin conjugating system Q9Y2Z0 10910 13q14.3 human S321-p 23149643 QQIYSDGsDEVKRAM SGS protein stabilization; molecular association, regulation cell cycle regulation RNF41(INDUCES) 28696259 1 10 1 +BTLA BTLA Membrane protein, integral Q7Z6A9 151888 3q13.2 human Y226-p 1869334004 LLSETGIyDNDPDLC phosphorylation signaling pathway regulation 32437509 1 0 0 inhibits IL2 production, phosphorylation of CD3Z and CD28, and hence T cell signaling +Mapk8ip1 JIP1 Adaptor/scaffold Q9WVI9 19099 2|2 E1 mouse Y427-p 234613500 ESAIGEEyEEAPQPR molecular association, regulation Src iso1(INDUCES) 28930674 1 0 0 +Dapk3 DAPK3 EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, CAMK; Protein kinase, Ser/Thr (non-receptor); Tumor suppressor O54784 13144 10 C1|10 39.72 cM mouse T265-p 454892 KDPKRRMtIAQSLEH Pkinase enzymatic activity, induced apoptosis, induced 16325270 4 2 0 A T265A mutant is unable to activate STAT3 in response to IL-6 stimulation +NPM/ALK NPM-ALK KINASE; Kinase, protein; Protein kinase, TK; Protein kinase, tyrosine (receptor) AAA58698 human Y567-p 27275100 TSLWNPTyGSWFTEK molecular association, regulation transcription, induced SNTB1(INDUCES); SHC1(INDUCES) 17086210; 17110082; 8633037 4 2 1 +KLC2 KLC2 Microtubule-binding; Motor Q9H0B6 64837 11q13.2 human S545-p 3892542 GSLRRSGsFGKLRDA molecular association, regulation 14-3-3 beta(INDUCES) 21725060 1 10 10 mutation of this site prevents 14-3-3 binding (pan-14-3-3 antibody) +CENPQ CENPQ Q7L2Z9 55166 6p12.3 human S248-p 40245501 DLDILHNsSQMKSMS CENP-Q molecular association, regulation; intracellular localization DNA(DISRUPTS) 25670858 1 1 0 CENPQ phosphorylation promotes the delocalization of the PBIP1-CENPQ complex from kinetochores +Chek2 Chk2 EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, CAMK; Protein kinase, Ser/Thr (non-receptor); Tumor suppressor Q9Z265 50883 5|5 F mouse T391-p 447552 LMRTLCGtPTYLAPE Pkinase DNA repair, induced; apoptosis, induced 35663228 18 5 0 +GJA1 GJA1 Channel, misc.; Membrane protein, integral; Membrane protein, multi-pass; Motility/polarity/chemotaxis P17302 2697 6q22.31 human Y247-p 447814 VKGKSDPyHATSGAL intracellular localization; protein conformation 23828237; 30448479 14 9 248 contributes to gap junction disassembly +Cdc25b CDC25B EC 3.1.3.48; Motility/polarity/chemotaxis; Nuclear receptor co-regulator; PHOSPHATASE; Protein phosphatase, dual-specificity P30306 12531 2 F1|2 63.29 cM mouse S351-p 452008 VQSKRRKsVTPLEEQ M-inducer_phosp cell cycle regulation; cytoskeletal reorganization 17554083; 25349079 8 13 9 promotes meiotic resumption +Cdkn1a p21Cip1 Cell cycle regulation; Inhibitor P39689 12575 17 A3.3|17 15.12 cM mouse S78-p 14577356 GLPKVYLsPGSRSRD activity, inhibited apoptosis, altered 21325496 2 9 0 S78 phosphorylation limits p21 inhibition of Cdk2. S78 regulates apoptosis in response to cisplatin. +MRE11 MRE11A Cell cycle regulation; DNA repair, damage; DNA-binding; Deoxyribonuclease P49959 4361 11q21 human S676-p 460788 TSSSKIMsQSQVSKG molecular association, regulation DNA repair, induced; chromatin organization, altered DNA(DISRUPTS) 19709933; 26240375 2 9 12 +PPARG PPAR-gamma iso2 DNA-binding; Nuclear receptor; Transcription factor P37231-2 5468 3p25.2 human S84-p 448062 AIKVEPAsPPYYSEK cell growth, induced; transcription, induced 27769068 33 7 0 promoter of PFKFB4 +Thrb TR-beta1 iso2 DNA-binding; Nuclear receptor P37242-2 21834 mouse S101-p 1877436600 KPFPQVQsPPHSQKK molecular association, regulation transcription, inhibited RXRA(INDUCES); TR-beta1 iso2(DISRUPTS) 34544870 1 1 0 +NFATC1 NFAT2 DNA-binding; Transcription factor O95644 4772 18q23 human K612-ac 9908948 SYPVVGGkKMVLSGH RHD_dimer protein stabilization; phosphorylation 32696520 1 0 1 hypoacetylation, induced higher phosphorylation, induces hair loss (regulated by Sirt7) +Rara RARA DNA-binding; Nuclear receptor; Oncoprotein; Transcription factor P11416 19401 11 D|11 62.76 cM mouse K109-me 4089801 VSACEGCkGFFRRSI zf-C4 activity, induced; molecular association, regulation transcription, induced RXRA(INDUCES); PCAF(INDUCES); RIP140(INDUCES) 18781795 1 1 0 +Rab3il1 RAB3IL1 GEF; GEF, Rab Q99NH3 171452 1q43 rat S180-p 467059 ELHPQLLsPTKAGPR activity, inhibited cell motility, induced; cytoskeletal reorganization 28123016 1 21 23 suppresses RAB3IL1 GEF activity; regulates axonal outgrowth +Mok MOK EC 2.7.11.22; KINASE; Kinase, protein; Protein kinase, CMGC; Protein kinase, Ser/Thr (non-receptor) Q9WVS4 26448 12|12 F1 mouse Y161-p 450006 SKQPYTEyISTRWYR Pkinase activity, induced 10421840 1 1 0 While the authors did not prove that these sites were phosphorylated, mutation of both T159 and Y161, located in the activation loop, abolished the enzymatic activity of the kinase. +HADHA HADHA ACETYLTRANSFERASE; Acetyltransferase; Amino Acid Metabolism - lysine degradation; Amino Acid Metabolism - tryptophan; Amino Acid Metabolism - valine, leucine and isoleucine degradation; Carbohydrate Metabolism - butanoate; Carbohydrate Metabolism - propanoate; EC 1.1.1.211; EC 4.2.1.17; Lipid Metabolism - fatty acid; Lipid Metabolism - fatty acid elongation in mitochondria; Lipid Metabolism - unsaturated fatty acid biosynthesis; Lyase; Mitochondrial; Other Amino Acids Metabolism - beta-alanine; Oxidoreductase; Secondary Metabolites Metabolism - limonene and pinene degradation P40939 3030 2p23.3 human K383-ub 56842401 IAQVSVDkGLKTILK 3HCDH_N protein degradation; ubiquitination 27457618 1 0 0 +TRIM65 TRIM65 Ubiquitin conjugating system Q6PJ69 201292 17q25.1 human S166-p 1871608301 LLELRKQsSQIQNSA carcinogenesis, inhibited; signaling pathway regulation 31332286 1 1 0 dephosphorylated form (6A mutant) contributes to TRIM65 function in tumor progression +BCL9 Bcl-9 Oncoprotein; Transcription factor O00512 607 1q21.2 human K212-ub 1878196102 IQNISNNkTERSTAP molecular association, regulation cell growth, inhibited CTNNB1(DISRUPTS); PYGO1(DISRUPTS) 31073027 1 1 0 ubiquitination inhibits Beta-catenin/BCL9/PYGO1 complex and proliferation and breast cancer cell proliferation +PDHA1 PDHA1 Amino Acid Metabolism - valine, leucine and isoleucine biosynthesis; Carbohydrate Metabolism - butanoate; Carbohydrate Metabolism - citrate (TCA) cycle; Carbohydrate Metabolism - glycolysis and gluconeogenesis; Carbohydrate Metabolism - pyruvate; EC 1.2.4.1; Mitochondrial; Oxidoreductase P08559 5160 Xp22.12 human S314-p 1868287349 IQEVRSKsDPIMLLK E1_dh molecular association, regulation; phosphorylation; enzymatic activity, induced carcinogenesis, induced; apoptosis, inhibited PDHK1(DISRUPTS) 33022274 1 2 0 inhibits phosphorylation at S293 and induces phosphorylation at S295 +GRIA1 GluR1 Channel, calcium; Channel, ligand-gated; Membrane protein, integral; Membrane protein, multi-pass P42261 2890 5q33.2 human S863-p 448566 TSTLPRNsGAGASSG molecular association, regulation; ubiquitination NEDD4(DISRUPTS) 28377502 102 0 0 GluA1 ubiquitin-deficient mutant enhances GluA1 phosphorylation on S863, blocks GluA1 ubiquitination by reducing its interaction with Nedd4 +PRKD3 PRKD3 EC 2.7.11.13; KINASE; Kinase, protein; Protein kinase, CAMK; Protein kinase, Ser/Thr (non-receptor) O94806 23683 2p22.2 human S731-p 456755 ARIIGEKsFRRSVVG Pkinase intracellular localization; enzymatic activity, induced cell motility, induced 16198087; 18692497; 24840177 3 13 19 Loss of Barbed End Formation for activities above basal level +TOP2A TOP2A EC 5.99.1.3; Isomerase P11388 7153 17q21.2 human K662-sm 55439454 KKQIDDRkEWLTNFM TOPRIM_C activity, induced; intracellular localization 30871006 1 2 0 influences mitotic localization of TOP2A +Septin3 SEPT3 Cell cycle regulation; Cytoskeletal; Hydrolase Q9WU34 56003 7q34 rat S91-p 453431 SQVSRKAsSWNREEK Septin intracellular localization 15107017 1 0 1 +DROSHA DROSHA EC 3.1.26.3; Nucleolus; RNA processing; RNA-binding; Ribonuclease Q9NRR4 29102 5p13.3 human S221-p 23100760 KAPSERRsPERLKHY molecular association, regulation DGCR8(DISRUPTS) 25699712 1 4 1 +Bnip3 BNIP3 Membrane protein, integral; Mitochondrial Q9ET45 84480 1q41 rat S60-p 17548869 SKSSHCDsPPRSQTP BNIP3 protein stabilization; molecular association, regulation; ubiquitination autophagy, induced LC3B(INDUCES); ubiquitin(DISRUPTS) 36396625 2 14 0 inhibits ubiquitination, induces mitophagy +Ifitm3 IFITM3 Cell surface; Membrane protein, integral Q9CQW9 66141 7|7 F5 mouse Y20-p 463584 SGGQPPNyERIKEEY ubiquitination; intracellular localization carcinogenesis, induced; cell growth, induced; signaling pathway regulation; endocytosis, inhibited 24627473; 33149299 5 10 18 induces PI3K-signaling; ubiquitination, decreased +Tal1 TAL1 DNA-binding; Oncoprotein; Transcription factor P22091 21349 4 D1|4 52.73 cM mouse K222-ac 458992 PTHPPDKkLSKNEIL HLH molecular association, regulation cell differentiation, induced; transcription, induced SIN3A(DISRUPTS) DNA(INDUCES) 11118214 1 1 0 +DNM1L DRP1 Apoptosis; EC 3.6.5.5; Endoplasmic reticulum; Hydrolase; Microtubule-binding; Mitochondrial; Motor O00429 10059 12p11.21 human K558-sm 9859918 ASAEADGkLIQDSRR activity, induced; intracellular localization 19638400 1 0 0 sumoylation is linked to its GTPase activity cycle, and influenced by DRP1 localization +NFKB1 NFkB-p105 DNA-binding; Transcription factor P19838 4790 4q24 human S80-p 1869465801 SSEKNKKsYPQVKIC RHD_DNA_bind molecular association, regulation transcription, altered DNA(DISRUPTS) 31598684 1 0 0 +NFE2L2 NRF2 DNA-binding; Transcription factor Q16236 4780 2q31.2 human R437-me 56423804 LPVSPGHrKTPFTKD molecular association, regulation transcription, induced DNA(INDUCES) 27183873 1 0 0 +H3c1 H3 DNA-binding P68433 360198 13|13 A3.1 mouse K9-m2 459006 RTKQTARkSTGGKAP Histone molecular association, regulation cell cycle regulation; cell growth, induced; apoptosis, induced; chromatin organization, altered; transcription, inhibited; transcription, altered CBX1(INDUCES) 11242053; 17823087; 18039862; 19910458; 20067909; 20561915; 35293595 119 21 0 H3K9m3 leads to heterochromatin and proliferation +MAPT Tau iso8 ACETYLTRANSFERASE; Acetyltransferase; Cytoskeletal P10636-8 4137 17q21.31 human S214-p 447929 GSRSRTPsLPTPPTR molecular association, regulation; intracellular localization; protein conformation; phosphorylation cytoskeletal reorganization WWOX(INDUCES); APOE(INDUCES); TUBB(INDUCES) 10090741; 15126504; 15364924; 16982696; 16987243; 18725412; 20550628; 20639351; 20679343; 33890983 63 24 42 +TRADD TRADD Adaptor/scaffold; Apoptosis Q15628 8717 16q22.1 human S215-p 20831309 PVVNRPLsLKDQQTF molecular association, regulation transcription, induced FADD(INDUCES); TNF-R1(INDUCES); RIP(INDUCES) 21724995 1 0 0 +SPP1 osteopontin Secreted; Secreted, signal peptide P10451 6696 4q22.1 human S117-p 455736 DVDDTDDsHQSDESH Osteopontin molecular association, regulation; activity, inhibited Other(INDUCES) 19775205 1 4 0 peptide with phosphorylated S117, S120, S123, S126 and S129 has increased binding to hydroxyapatite, and inhibits bone mineralization in vivo and in vitro +Sod2 SOD2 EC 1.15.1.1; Mitochondrial; Oxidoreductase P09671 20656 17 A1|17 8.75 cM mouse K130-ac 7248076 RDFGSFEkFKEKLTA Sod_Fe_C intracellular localization; protein conformation 28433661 2 10 12 mediates pentameric SOD2 deaggregation; importation into mitochondria +GFAP GFAP Cytoskeletal F1RR02 396562 pig S34-p 449621 LGPGPRLsLARMPPP Filament_head cell cycle regulation 1379174 6 3 0 +CASP7 CASP7 Apoptosis; EC 3.4.22.60; Endoplasmic reticulum; Mitochondrial; Protease P55210 840 10q25.3 human S30-p 12069580 DAKPDRSsFVPSLFS activity, inhibited cell growth, induced; apoptosis, inhibited CASP9(DISRUPTS) 21555521; 27889207 2 1 1 +NBN NBS1 Cell cycle regulation; DNA repair, damage O60934 4683 8q21.3 human K665-ac 487513 EFRSLVIkNSTSRNP phosphorylation cell cycle regulation; apoptosis, induced 17612497 2 1 0 inhibits phosphorylation at S343 +EIF2AK2 PKR EC 2.7.10.2; EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, Other; Protein kinase, Ser/Thr (non-receptor); Protein kinase, tyrosine (non-receptor); Translation P19525 5610 2p22.2 human T255-p 448086 DLPDMKEtKYTVDKR enzymatic activity, induced 11152499 2 0 0 +NTRK1 TrkA EC 2.7.10.1; KINASE; Kinase, protein; Membrane protein, integral; Oncoprotein; Protein kinase, TK; Protein kinase, tyrosine (receptor) P04629 4914 1q23.1 human Y757-p 449758 RACPPEVyAIMRGCW PK_Tyr_Ser-Thr activity, induced 16319926 3 0 0 mutation of site abolished phosphorylation and NGF-induced sensitization of VR1 +Tiam1 TIAM1 GEF; GEF, Rac/Rho; Motility/polarity/chemotaxis; Oncoprotein Q60610 21844 16 C3.3|16 51.5 cM mouse S231-p 468938 STCQRANsLGDLYAQ molecular association, regulation 14-3-3 zeta(INDUCES) 19899799 2 43 6 +Cyth1 cytohesin 1 GEF; GEF, ARF; Motility/polarity/chemotaxis P97694 116691 10q32.2-q32.3 rat Y382-p 464074 AISRDPFyEMLAARK activity, induced 23012656 2 0 147 myelination +STAT5B STAT5B DNA-binding; Oncoprotein; Transcription factor P51692 6777 17q21.2 human K694-ac 62484405 PCESATAkAVDGYVK phosphorylation transcription, induced 23980167 1 0 0 increases pSTAT5B at Y699 +FOXO1 FOXO1A DNA-binding; Nuclear receptor co-regulator; Oncoprotein; Transcription factor Q12778 2308 13q14.11 human S325-p 449114 SSNASTIsGRLSPIM intracellular localization 11980723; 14664696 5 1 0 +SSBP3 SSBP3 Cell cycle regulation; DNA-binding; Transcription regulation Q9BWW4 23648 1p32.3 human Y23-p 1806900 AREKLALyVYEYLLH activity, induced; intracellular localization transcription, induced 18080319 1 0 0 +MAP3K7 TAK1 EC 2.7.11.25; KINASE; Kinase, protein; Protein kinase, Ser/Thr (non-receptor); Protein kinase, TKL O43318 6885 6q15 human K72-ub 25698801 IESESERkAFIVELR PK_Tyr_Ser-Thr protein degradation transcription, inhibited 22406003 1 1 0 +Sod2 SOD2 EC 1.15.1.1; Mitochondrial; Oxidoreductase P09671 20656 17 A1|17 8.75 cM mouse K132-ac 3852802 FGSFEKFkEKLTAVS Sod_Fe_C enzymatic activity, altered 28433661 0 3 7 +AKT1 Akt1 EC 2.7.11.1; KINASE; Kinase, protein; Oncoprotein; Protein kinase, AGC; Protein kinase, Ser/Thr (non-receptor) P31749 207 14q32.33 human K64-m3 1883432305 VAQCQLMkTERPRPN carcinogenesis, induced; signaling pathway regulation 35184652 1 0 0 EZH2 promotes HCC cell tumorigenesis and chemoresistance via the miR-381/ SETDB1/AKT pathway +IRF5 IRF5 DNA-binding; Transcription factor Q13568 3663 7q32.1 human Y313-p 57775901 PSDKQRFyTNQLLDV IRF-3 molecular association, regulation; ubiquitination transcription, inhibited LYN(INDUCES) 27521268 1 1 0 inhibition of IRF5 activation by Lyn requires their physical Interaction, Lyn inhibits IRF5 ubiquitination and phosphorylation by protecting IRF5 from each of PTM enzymes +Grb14 GRB14 Adaptor/scaffold O88900 58844 3q21 rat Y345-p 20745205 LKYGMQLyQNYMHPS molecular association, regulation PTP1B(INDUCES) 21791607 1 0 0 +FOXP3 FOXP3 C2H2-type zinc finger protein; Cell cycle regulation; DNA-binding; Transcription factor Q9BZS1 50943 Xp11.23 human K356-ub 56786301 AILEAPEkQRTLNEI Forkhead protein degradation; ubiquitination 27432879 1 1 0 +PRKDC DNAPK DNA repair, damage; EC 2.7.11.1; KINASE; Kinase, protein; Nucleolus; Protein kinase, Ser/Thr (non-receptor); Protein kinase, atypical P78527 5591 8q11.21 human S2612-p 448711 MFVETQAsQGTLQTR DNAPKcs_CC5 molecular association, regulation; protein conformation DNA repair, induced; chromatin organization, altered; cell growth, altered DNA(DISRUPTS) 17189255; 24687855 6 21 56 increases survival in ionizing radiation and repairing double strand DNA breaks; cell survival induced, induces removal of cisplatin adducts from DNA, induces end processing +KAT2B PCAF ACETYLTRANSFERASE; Acetyltransferase; EC 2.3.1.48; Nuclear receptor co-regulator Q92831 8850 3p24.3 human K430-ac 458986 ANPGEKRkMTDSHVL enzymatic activity, induced 12888487 1 0 0 in vitro +RPS6KB2 P70S6KB EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, AGC; Protein kinase, Ser/Thr (non-receptor); Translation Q9UBS0 6199 11q13.2 human S473-p 450071 PPSGTKKsKRGRGRP intracellular localization 12529391 1 0 0 +APP APP Apoptosis; Cell surface; Membrane protein, integral; Receptor, misc.; Transcription factor P05067 351 21q21.3 human C187-pa 62489907 RGVEFVCcPLAEESD APP_Cu_bd molecular association, regulation APP(INDUCES) 27875558 1 0 0 palAPP dimerizes ~4.5 times more efficiently +WRN WRN Cell cycle regulation; DNA repair, damage; DNA-binding; EC 3.6.4.12; Helicase; Nucleolus Q14191 7486 8p12 human S1133-p 10940893 KKSIMVQsPEKAYSS molecular association, regulation; intracellular localization DNA repair, induced MRE11A(INDUCES) 27634057 3 23 1 association of WRN with the MRE11 complex and MRE11 foci-formation after replication-dependent DSBs +BCAR1 P130Cas Adaptor/scaffold; Motility/polarity/chemotaxis P56945 9564 16q23.1 human Y664-p 448399 EGGWMEDyDYVHLQG CAS_C carcinogenesis, induced; cell motility, induced; cell adhesion, induced; cytoskeletal reorganization 22084245 6 2 24 P130Cas phosphorylation is important in development of peripheral adhesion complexes, oncogenic signaling, and cell migration. +MT-CO1 COX1 EC 1.9.3.1; Energy Metabolism - oxidative phosphorylation; Membrane protein, integral; Membrane protein, multi-pass; Mitochondrial; Oxidoreductase P00396 cow Y304-p 454437 MDVDTRAyFTSATMI COX1; TM enzymatic activity, inhibited signaling pathway regulation 15557277; 18534980; 21771582 3 2 0 regualtion of electron transport chain +TSC1 TSC1 Motility/polarity/chemotaxis; Tumor suppressor Q92574 7248 9q34.13 human T417-p 450279 SLPQATVtPPRKEER Hamartin molecular association, regulation; intracellular localization apoptosis, altered TSC2(INDUCES); HSP70(INDUCES) 20006582 2 0 0 +Runx2 AML3 iso5 DNA-binding; Transcription factor Q08775-5 12393 17 B3|17 21.33 cM mouse S301-p 10892804 DPRQAQSsPPWSYDQ activity, induced; acetylation; intracellular localization carcinogenesis, induced; cell differentiation, induced; cell motility, induced; chromatin organization, altered; transcription, induced 20484411; 22337141; 25867060; 26206105; 27341689 10 2 0 +Scnn1b ENaC-beta Channel, sodium; Membrane protein, integral; Membrane protein, multi-pass; Transporter, ion channel P37090 24767 1q36 rat T613-p 451219 QTLPIPGtPPPNYDS molecular association, regulation; intracellular localization; activity, inhibited NEDD4L(DISRUPTS) 11805112; 16476738; 29397423 6 1 0 enhances Nedd4-2-mediated ENaC retrieval from the plasma membrane; negatively regulates expression of ENaC at the plasma membrane; necessary for inhibitory effect of Nedd4-2 on ENaC function +KRT18 K18 Cytoskeletal; Nucleolus P05783 3875 12q13.13 human S53-p 447734 ISVSRSTsFRGGMGS molecular association, regulation; protein processing; intracellular localization cell motility, induced; apoptosis, induced; cytoskeletal reorganization; transcription, altered ITGB1(INDUCES) 10623656; 15368451; 16424149; 17084817; 17898082; 25537517; 32365802; 8522590 17 12 14 EGF stimulated, membrane ruffling, metastasis; regulates expression of REG3C and REG3G; implicated in reorganization of intermediate filaments; S52 phosphorylation increases during S and G2/M stages of the cell cycle. Phosphorylated S52 is preferentially found in reorganized filaments and in specific cellular domains. ; induces solubility of keratin filaments and inhibits polymerization +KIF20A KIF20A Microtubule-binding; Motor O95235 10112 5q31.2 human T198-p 32007200 LQGQLHPtPDLKPLL Kinesin molecular association, regulation; intracellular localization; protein conformation cell cycle regulation INCENP(DISRUPTS) 24656812 1 0 0 favours solubility, inhibits microtubule binding +Panx1 PANX1 Cell adhesion; Membrane protein, integral; Membrane protein, multi-pass P60570 315435 8q12 rat S394-p 14577460 TKGEDQGsQRMDFKD activity, induced; receptor internalization, induced; protein conformation 34301850 1 1 0 +H3F3C H3 DNA-binding P84229 427887 chicken K4-m3 1458621 ____ARTkQTARKST Histone chromatin organization, altered; transcription, induced 17913747; 23028147 178 10 0 +IKBKG IKKG Adaptor/scaffold; Protein kinase, regulatory subunit Q9Y6K9 8517 Xq28 human S31-p 449036 QDVLGEEsPLGKPAM protein stabilization transcription, induced 27929056 2 4 9 +Pik3ap1 BCAP Adaptor/scaffold Q9EQ32 83490 19|19 C3 mouse Y264-p 12520500 CETTVSYyTDMEEIG DBB molecular association, regulation cell differentiation, altered PIK3R1(INDUCES) 18025150 1 0 0 regulate Akt activation and B-cell differentiation through binding to PI3KR1 +TSC2 TSC2 Cell cycle regulation; GAP; GAP, misc.; Nuclear receptor co-regulator; Tumor suppressor P49815 7249 16p13.3 human R1459-me 1877221603 SPSGLRPrGYTISDS protein stabilization; phosphorylation signaling pathway regulation 33273660 1 0 0 mTOR activity; inhibits phosphorylation +ITCH ITCH iso2 EC 6.3.2.-; EC 6.3.2.19; Ligase; UBIQUITIN LIGASE; Ubiquitin conjugating system; Ubiquitin ligase Q96J02-2 83737 20q11.22 human T222-p 459624 PSRPPPPtPRRPASV enzymatic activity, induced 27203743 3 0 0 HER3 ubiquitination and degradation in cancer cells +FOXO3 FOXO3A Autophagy; DNA-binding; Oncoprotein; Transcription factor O43524 2309 6q21 human T32-p 448602 QSRPRSCtWPLQRPE activity, induced; molecular association, regulation; intracellular localization; activity, inhibited signaling pathway regulation; transcription, altered 14-3-3 beta(INDUCES) DNA(INDUCES) 18593906; 20110348; 21750219; 26376801; 27451907 74 8 91 Regulation of PI3K/mTOR signaling; cell viability induced +MYLK smMLCK EC 2.7.11.18; KINASE; Kinase, protein; Protein kinase, CAMK; Protein kinase, Ser/Thr (non-receptor) P11799 396445 chicken S149-p 17555039 PPVEHRPsIWGESPP molecular association, regulation ACTB(DISRUPTS) 26567572 1 3 0 in vitro the single S149D mutation reduced N27-157 association with F-actin +Pik3r3 PIK3R3 Kinase, lipid; Motility/polarity/chemotaxis Q64143 18710 4|4 D1 mouse Y199-p 450746 SKEYDRLyEEYTRTS PI3K_P85_iSH2 cell cycle regulation; carcinogenesis, induced; cell motility, induced; cell growth, induced; apoptosis, inhibited 36310322 7 28 746 +Mitf MITF DNA-binding; Oncoprotein; Transcription factor Q08874 17342 6 D3|6 45.05 cM mouse K423-sm 3590700 DLVNRIIkQEPVLEN DUF3371 transcription, inhibited 16029420 3 1 0 +PRKACA PKACA EC 2.7.11.11; KINASE; Kinase, protein; Protein kinase, AGC; Protein kinase, Ser/Thr (non-receptor) P17612 5566 19p13.12 human T198-p 448459 RVKGRTWtLCGTPEY Pkinase protein stabilization; protein conformation; phosphorylation; enzymatic activity, induced endocytosis, inhibited 15481030; 16026785; 22154087; 22493239; 34497151 34 48 277 induces RhoA phosphorylation +Rps6kb2 P70S6KB EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, AGC; Protein kinase, Ser/Thr (non-receptor); Translation Q9Z1M4 58988 19|19 A mouse S423-p 455991 SSPRTPIsPLKFSPF phosphorylation 17980619 2 18 44 +Klf4 KLF4 C2H2-type zinc finger protein; DNA-binding; Transcription factor Q60793 16600 4 B3|4 29.76 cM mouse K275-sm 14988613 PRMCPKIkQEAVPSC cell growth, inhibited; transcription, induced 20584900 2 0 0 +H2bc15 H2B DNA-binding P10853 319187 13|13 A3.1 mouse K120-ub 465519 EGTKAVTkYTSSK__ cell cycle regulation; cell differentiation, altered; cell differentiation, induced; transcription, induced; transcription, inhibited; transcription, altered 32341358; 32797353 35 21 138 +SOX4 SOX4 DNA-binding; Transcription factor Q06945 6659 6p22.3 human K95-ac 49182101 EISKRLGkRWKLLKD HMG_box chromatin organization, altered; cell differentiation, induced; transcription, induced 26291311 1 0 0 +Plcg1 PLCG1 Carbohydrate Metabolism - inositol phosphate; EC 3.1.4.11; Motility/polarity/chemotaxis; Phospholipase Q62077 18803 2 H2|2 80.97 cM mouse Y771-p 448575 IGTAEPDyGALYEGR molecular association, regulation; protein conformation cell cycle regulation; cell motility, altered PLCG1(INDUCES) 18515860; 26687682 16 41 552 +MAOA MAOA Amino Acid Metabolism - arginine and proline; Amino Acid Metabolism - glycine, serine and threonine; Amino Acid Metabolism - histidine; Amino Acid Metabolism - phenylalanine; Amino Acid Metabolism - tryptophan; Amino Acid Metabolism - tyrosine; EC 1.4.3.4; Membrane protein, integral; Oxidoreductase; Xenobiotic Metabolism - drug metabolism - cytochrome P450 P21397 4128 Xp11.3 human S209-p 9726600 GGTTRIFsVTNGGQE Amino_oxidase protein degradation; enzymatic activity, inhibited; protein conformation 19645722; 19650872 2 0 0 +RPA2 RFA2 DNA replication P15927 6118 1p35.3 human S8-p 470083 MWNSGFEsYGSSSYG molecular association, regulation; intracellular localization cell cycle regulation; DNA repair, induced; carcinogenesis, inhibited; apoptosis, induced; transcription, altered; cell growth, altered p53(INDUCES); WRN(INDUCES) 17035231; 18003706; 18289945; 21107010; 21731742; 29875999; 30573684; 32989256; 37409248 48 2 0 +RORA RORA DNA-binding; Nuclear receptor P35398 6095 15q22.2 human S35-p 12613703 ETPLNQEsARKSEPP molecular association, regulation cell motility, altered; cell growth, altered CTNNB1(INDUCES) DNA(INDUCES) 20122401 1 1 0 downregulates the Wnt signaling +MAP2K2 MEK2 EC 2.7.12.2; KINASE; Kinase, protein; Protein kinase, STE; Protein kinase, dual-specificity (non-receptor) P36507 5605 19p13.3 human S216-p 455802 KLCDFGVsGQLIDSM Pkinase enzymatic activity, inhibited 12506122 3 2 3 +UBR5 UBR5 EC 6.3.2.-; EC 6.3.2.19; Ligase; Nuclear receptor co-regulator; UBIQUITIN LIGASE; Ubiquitin conjugating system; Ubiquitin ligase O95071 51366 8q22.3 human T637-p 3952394 PYKRRRStPAPKEEE translation, inhibited 28559278 1 5 10 translational repression of TRAF3 mRNA +Npas4 NPAS4 DNA-binding Q8BGD7 225872 19|19 A mouse T611-p 1871095703 LVPEGLLtPEASPVK molecular association, regulation neural plasticity; transcription, induced CBP(INDUCES) 31801086 1 1 0 +Prkcd PKCD EC 2.7.11.13; KINASE; Kinase, protein; Nuclear receptor co-regulator; Protein kinase, AGC; Protein kinase, Ser/Thr (non-receptor); Protein kinase, tyrosine (non-receptor); Tumor suppressor P28867 18753 14 B|14 18.82 cM mouse Y155-p 447575 IKQAKIHyIKNHEFI protein degradation; molecular association, regulation; intracellular localization cell cycle regulation; cell motility, induced; apoptosis, induced; cell adhesion, induced; apoptosis, inhibited; cell growth, altered KPNA2(INDUCES) 10783308; 10945993; 15774464; 18059334; 21865164; 30095599 11 0 0 induces O2 production and NET formation, increases permeability, regulates inflammation; PKCD-induced apoptosis +ASF1A ASF1A DNA repair, damage; Histone-binding Q9Y294 25842 6q22.31 human S192-p 12671900 GWSTSENsLNVMLES molecular association, regulation; protein stabilization; ubiquitination DNA repair, induced; chromatin organization, altered MMS22L(INDUCES); CAF-1A(INDUCES); H3(INDUCES); H3 iso3(INDUCES); H4(INDUCES) DNA(INDUCES) 20016786; 29478807 2 3 0 +MAP3K11 MLK3 EC 2.7.11.25; KINASE; Kinase, protein; Protein kinase, Ser/Thr (non-receptor); Protein kinase, TKL Q16584 4296 11q13.1 human T738-p 4271419 EEEPRGGtVSPPPGT phosphorylation; enzymatic activity, induced carcinogenesis, induced; cell motility, induced; cell growth, induced; apoptosis, inhibited 34511598 1 4 0 induces c-Jun phosphorylation +Trpv5 TRPV5 Channel, cation; Membrane protein, integral; Membrane protein, multi-pass; Motility/polarity/chemotaxis Q9XSM3 rabbit T709-p 4710939 WEILRRNtLGHLNLG activity, induced 19423690 3 1 0 +MAFG MAFG Cell cycle regulation; DNA-binding O15525 4097 17q25.3 human K60-ac 458965 KQRRRTLkNRGYAAS bZIP_Maf molecular association, regulation DNA(INDUCES) 11154691 1 0 0 +NPFFR2 NPFFR2 GPCR, family 1; Membrane protein, integral; Membrane protein, multi-pass; Receptor, GPCR Q9Y5X5 10886 4q13.3 human S500-p 36533414 ETLLYRKsAEKPQQE receptor internalization, induced 25326382 1 1 0 +ACOT4 ACOT4 EC 3.1.2.2; Hydrolase; Lipid Metabolism - unsaturated fatty acid biosynthesis Q8N9L9 122970 14q24.3 human S392-p 1871177703 GGEPRAHsKAQEDAW BAAT_C protein stabilization; molecular association, regulation carcinogenesis, induced HSP70(DISRUPTS) 33148467 1 1 0 +LOC100399755 GNRHR2 GPCR, family 1; Membrane protein, integral; Membrane protein, multi-pass; Receptor, GPCR Q95MG6 100399755 marmoset S338-p 454393 HQELSMDsSREEGSR receptor internalization, altered 15205374 1 0 0 +STXBP5L STXBP5L Q9Y2K9 9515 3q13.33 human S823-p 4724310 SRSSSISsIDKDSKE Lgl_C protein degradation 25002582 1 6 9 ; in a multiple residue S->D mutant +CDCA2 CDCA2 Q69YH5 157313 8p21.2 human S977-p 10424830 EPGKRRKsFCISTLA molecular association, regulation cell cycle regulation; chromatin organization, altered PPP1CC(DISRUPTS) 32938714 1 10 3 regulation chromosome condesation rate +ANLN anillin iso2 Actin-binding; Motility/polarity/chemotaxis Q9NQW6-2 54443 7p14.2 human S635-p 15228550 EDRDLLYsIDAYRSQ intracellular localization cell cycle regulation 28081137 1 1 5 anillin recruitment to the equatorial cortex at anaphase +CROCC CROCC iso2 Cytoskeletal Q5TZA2-2 9696 1p36.13 human S763-p 14159744 APRPVPGsPARDAPA carcinogenesis, induced; cell growth, induced; signaling pathway regulation 22610972 1 14 4 +MAP2K1 MEK1 EC 2.7.12.2; KINASE; Kinase, protein; Protein kinase, STE; Protein kinase, dual-specificity (non-receptor) Q02750 5604 15q22.31 human T286-p 448286 VEGDAAEtPPRPRTP Pkinase enzymatic activity, inhibited; phosphorylation signaling pathway regulation 12609978; 25971971; 8114697 8 6 16 induces phosphorylation of T292 by CDK5, inhibits ERK phosphorylation, regulates Ras/MEK/ERK signaling +Nr0b2 NR0B2 Nuclear receptor; Nuclear receptor co-regulator; Transcription, coactivator/corepressor Q62227 23957 4 D2.3|4 66.25 cM mouse K123-ub 7596702 PVPSILKkILLEEAS Hormone_recep protein degradation 19390091 1 0 0 +ESR1 ER-alpha DNA-binding; Nuclear receptor; Transcription factor P03372 2099 6q25.1-q25.2 human K266-m1 31094523 RRGGRMLkHKRQRDD acetylation transcription, inhibited 24101509 1 1 0 inhibits acetylation at ER-alpha K266/268 +Abraxas2 ABRAXAS2 Ubiquitin conjugating system Q3TCJ1 109359 7|7 F3 mouse Y377-p 3196742 EESDDSDyENLIDPA molecular association, regulation LNK(INDUCES) 30755420 1 4 4 interaction with LNK further regulates LNK interaction with BRISC +CAMK2A CAMK2A EC 2.7.11.17; KINASE; Kinase, protein; Protein kinase, CAMK; Protein kinase, Ser/Thr (non-receptor) Q9UQM7 815 5q32 human T253-p 451571 DLINKMLtINPSKRI Pkinase cytoskeletal reorganization 20060891 8 5 1 +Wasl N-WASP Adaptor/scaffold; Motility/polarity/chemotaxis O08816 682507 4q22 rat T196-p 23003801 KAKKKRLtKADIGTP molecular association, regulation; protein conformation cytoskeletal reorganization 22250195 1 0 0 inhibits actin polymerization in vitro; inhibits the filopodia promoting activity of N-WASP +E2F1 E2F1 DNA-binding; Transcription factor Q01094 1869 20q11.22 human K125-ac 459019 GVKSPGEkSRYETSL protein stabilization; molecular association, regulation apoptosis, induced; transcription, induced DNA(INDUCES) 10675335; 10753885; 22184068 3 0 0 etoposide-induced DNA damage, pRB-free form of E2F1, does not bind to pRB; both complexes act in parallel to induce transcription of proapoptotic genes +CDK1 CDK1 Cell cycle regulation; EC 2.7.11.22; EC 2.7.11.23; KINASE; Kinase, protein; Motility/polarity/chemotaxis; Protein kinase, CMGC; Protein kinase, Ser/Thr (non-receptor) P06493 983 10q21.2 human K33-ac 461140 TGQVVAMkKIRLESE Pkinase enzymatic activity, inhibited cell cycle regulation CCNB1(DISRUPTS) 30974121 2 5 133 blocks cell-cycle progression in S. pombe +Vgll4 VGLL4 Transcription, coactivator/corepressor Q80V24 232334 6|6 E3 mouse K216-ac 59149206 HFRRSLGkNYKEPEP VGLL4 molecular association, regulation cell cycle regulation; cell growth, induced; transcription, induced; signaling pathway regulation TEAD1(DISRUPTS) 27720608 1 1 0 regulates Hippo-Yap signaling +EGFR EGFR EC 2.7.10.1; KINASE; Kinase, protein; Membrane protein, integral; Oncoprotein; Protein kinase, TK; Protein kinase, tyrosine (receptor) P00533 1956 7p11.2 human K713-ub 1065309 ILKETEFkKIKVLGS PK_Tyr_Ser-Thr receptor recycling, inhibited; protein degradation 16543144; 17940017 2 2 0 +EZH2 EZH2 EC 2.1.1.43; METHYLTRANSFERASE; Methyltransferase; Methyltransferase, protein lysine Q15910 2146 7q36.1 human K348-ac 40477503 ERIKTPPkRPGGRRR protein stabilization; molecular association, regulation; phosphorylation carcinogenesis, induced; cell motility, induced; transcription, inhibited DNA(INDUCES) 25800736; 31948940 2 1 0 inhibits phosphorylation at T345 and T487 +CTNNB1 CTNNB1 Actin-binding; Cell adhesion; Motility/polarity/chemotaxis; Nuclear receptor co-regulator; Oncoprotein; Transcription factor P35222 1499 3p22.1 human K394-ub 27850504 NLSDAATkQEGMEGL protein stabilization transcription, induced 22705350 1 0 0 +MET Met EC 2.7.10.1; KINASE; Kinase, protein; Membrane protein, integral; Oncoprotein; Protein kinase, TK; Protein kinase, tyrosine (receptor) P08581 4233 7q31.2 human Y1194-p 473312 QVAKGMKyLASKKFV PK_Tyr_Ser-Thr protein conformation; enzymatic activity, induced 14559966 1 0 2 +Gli2 GLI2 C2H2-type zinc finger protein; Oncoprotein; Transcription factor Q0VGT2 14633 1 E2.3|1 52.17 cM mouse S789-p 15410478 QLQERRDsSTSTMSS sumoylation 22549777 1 0 3 +OSMR OSMR Membrane protein, integral; Receptor, cytokine Q99650 9180 5p13.1 human Y861-p 458403 ICFENLTyNQAASDS molecular association, regulation; phosphorylation transcription, altered; cell growth, altered SHC1(INDUCES) 11016927; 15935618 3 0 6 required for ERK1/2, p38 and JNK activation; ERK activation +Irs1 IRS1 Adaptor/scaffold; Motility/polarity/chemotaxis P35570 25467 9q34 rat S662-p 2352501 PNGYMMMsPSGSCSP enzymatic activity, inhibited 8626671 2 1 6 The serine phosphorylation sites negatively regulate PI3 kinase activity associated with IRS-1. +Kcna2 Kv1.2 Channel, potassium; Membrane protein, integral; Membrane protein, multi-pass P63142 25468 2q34 rat S441-p 1818103 SCPKIPSsPDLKKSR intracellular localization 18056633 1 7 0 +PLK1 PLK1 EC 2.7.11.21; KINASE; Kinase, protein; Protein kinase, Other; Protein kinase, Ser/Thr (non-receptor) P53350 5347 16p12.2 human S326-p 5393500 LTIPPRFsIAPSSLD enzymatic activity, induced cell cycle regulation 18695677 1 2 0 +BAD BAD Apoptosis Q92934 572 11q13.1 human S118-p 447863 GRELRRMsDEFVDSF Bcl-2_BAD molecular association, regulation apoptosis, altered; apoptosis, inhibited 14-3-3 beta(INDUCES); Bcl-xL(DISRUPTS) 18794113; 21419810; 21849418 47 63 166 +CALD1 Caldesmon Actin-binding P12957 373965 chicken S672-p 456706 EGVRNIKsMWEKGNV Caldesmon molecular association, regulation Calmodulin(DISRUPTS) 20858431 5 0 0 +PPDPF PPDPF Unknown function Q9H3Y8 79144 20q13.33 human Y16-p 1883583902 SLVATHDyYRRRLGS protein stabilization; molecular association, regulation carcinogenesis, induced; cell growth, induced CK1A(INDUCES) 37477088 1 0 0 +FZD3 FZD3 GPCR, Fz/Smo family; Membrane protein, integral; Membrane protein, multi-pass; Receptor, GPCR Q9NPG1 7976 8p21.1 human T598-p 1869636102 RSRDGRYtPCSYRGM molecular association, regulation signaling pathway regulation VANGL2(DISRUPTS) 32641508 1 1 0 regulation of axonal PCP signaling and growth cone communications +RARA RARA DNA-binding; Nuclear receptor; Oncoprotein; Transcription factor P10276 5914 17q21.2 human S77-p 455459 EIVPSPPsPPPLPRI activity, induced; protein degradation; molecular association, regulation; activity, inhibited; protein conformation cell cycle regulation; carcinogenesis, induced; RNA stability, induced; transcription, induced; signaling pathway regulation; transcription, altered; apoptosis, inhibited; autophagy, inhibited; transcription, inhibited N-CoR1(INDUCES); RXRA(INDUCES); SRC-3(DISRUPTS); PIN1(INDUCES); CCNH(INDUCES) DNA(INDUCES) 11955452; 12054865; 15670742; 16769902; 19078967; 19917671; 21297158; 25849135; 33902658 11 2 0 +RAF1 RAF1 EC 2.7.11.1; KINASE; Kinase, protein; Oncoprotein; Protein kinase, Ser/Thr (non-receptor); Protein kinase, TKL P04049 5894 3p25.2 human T481-p 1811400 IFLHEGLtVKIGDFG PK_Tyr_Ser-Thr enzymatic activity, induced 16093354 1 2 0 mutation of T481 is less profound of an effect. B-Raf S579 shows similar effects to Raf1 S471.; Mutation of Raf1 S471 abolishes kinase activity and EGF-induced activity +Dab1 DAB1 iso2 Adaptor/scaffold P97318-2 13131 4 C6|4 47.79 cM mouse S400-p 479417 TNDSARSsPQSDKPR molecular association, regulation; intracellular localization; phosphorylation signaling pathway regulation SH3KBP1(DISRUPTS) 16529723; 23506116 3 0 0 regulates trafficking of reelin receptors and hence Reelin signaling pathway; inhibits tyrosine phosphorylation +Pea15 PEA-15 Apoptosis; Motility/polarity/chemotaxis Q62048 18611 1 H3|1 79.54 cM mouse S116-p 450281 KDIIRQPsEEEIIKL molecular association, regulation cell cycle regulation ERK1(DISRUPTS); ERK2(DISRUPTS) 15917297 15 95 1092 +STAT1 STAT1 DNA-binding; Transcription factor P42224 6772 2q32.2 human T749-p 56654462 EFDSMMNtV______ molecular association, regulation RNA stability, induced; transcription, induced DNA(INDUCES) 32209697 1 1 0 enhances binding to promoter of ARID5A and IL12B +SMAD4 SMAD4 DNA-binding; Nuclear receptor co-regulator; Transcription, coactivator/corepressor Q13485 4089 18q21.2 human T269-p 36694100 HNSTTTWtGSRTAPY protein degradation; molecular association, regulation; ubiquitination carcinogenesis, inhibited; transcription, inhibited; signaling pathway regulation BTRC(INDUCES) 25373906 1 0 0 +Ciz1 CIZ1 Cell cycle regulation Q8VEH2 68379 2|2 B mouse T293-p 15418576 TAPKQTQtPDRLPEP molecular association, regulation; activity, inhibited cell cycle regulation CCNA1(DISRUPTS) 25736292 1 1 1 phosphorylation of T293 and T192, T144 are required for interaction with the cyclinA-CDK2 complex and directing it to chromatin +Cdk16 CDK16 Cell cycle regulation; EC 2.7.11.22; KINASE; Kinase, protein; Motility/polarity/chemotaxis; Protein kinase, CMGC; Protein kinase, Ser/Thr (non-receptor) Q04735 18555 X A1.3|X 16.18 cM mouse S146-p 48921815 PIFDKPLsRRLRRVS molecular association, regulation; enzymatic activity, altered CCNYL1(INDUCES) 26305884 1 1 0 +FAAP20 FAAP20 iso2 Q6NZ36 199990 1p36.33 human K152-ac 1870026101 RSCPMCQkEFAPRLT UBZ_FAAP20 protein stabilization; ubiquitination 32763975 1 0 0 antagonizes FAAP20 ubiquitination and degradation +MYLK smMLCK EC 2.7.11.18; KINASE; Kinase, protein; Protein kinase, CAMK; Protein kinase, Ser/Thr (non-receptor) Q15746 4638 3q21.1 human S145-p 41411900 KTLGDRFsAPAVETR molecular association, regulation; protein conformation 14-3-3 beta(INDUCES) 26111161 2 1 0 minor local conformational changes +GSK3B GSK3B EC 2.7.11.1; EC 2.7.11.26; KINASE; Kinase, protein; Protein kinase, CMGC; Protein kinase, Ser/Thr (non-receptor) P49841 2932 3q13.33 human K15-ac 1876813500 TSFAESCkPVQQPSA protein stabilization; enzymatic activity, induced cytoskeletal reorganization 33107080; 35339896 2 1 0 overexpressing tau increases GSK-3b acetylation with inhibited ubiquitination and proteolysis, causes memory impairment and synaptic dysfunction, exacerbates tau hyperphosphorylation ; regulation of meiotic assembly of meiotic apparatus in mouse oocytes, mutant K15R alleviates the meiotic defects in oocytes from diabetic mice +ANPEP CD13 EC 3.4.11.2; Membrane protein, integral; Other Amino Acids Metabolism - glutathione; Protease; Receptor, misc. P15144 290 15q26.1 human Y6-p 29570700 __MAKGFyISKSLGI activity, induced; molecular association, regulation; receptor recycling, induced; intracellular localization; enzymatic activity, induced cell motility, induced; cell adhesion, induced; cytoskeletal reorganization ARF6(INDUCES); ACTN1(INDUCES); IQGAP1(INDUCES) 23997214; 31040262 2 0 0 Beta-1 integrin recycling to the cell surface, induce ARF6 activation; activation of the Src, FAK, and ERK kinases +STRAP STRAP Adaptor/scaffold; RNA splicing; UBIQUITIN LIGASE; Ubiquitin ligase Q9Y3F4 11171 12p12.3 human K148-ac 1876755701 GHTSGIKkALWCSED WD40 protein stabilization transcription, induced 32527012 1 0 0 upregulation and stabilization of p53 as well as its targets +GABBR2 GABBR2 GPCR, family 3; Membrane protein, integral; Membrane protein, multi-pass; Receptor, GPCR O75899 9568 9q22.33 human K772-ub 54191604 NQKKEDSkTSTSVTS protein degradation; ubiquitination 24114844; 26817839 2 0 0 +LHX3 LHX3 DNA-binding; Transcription factor Q9UBR4 8022 9q34.3 human S234-p 455298 YFRNMKRsRGGSKSD activity, induced transcription, induced 15517599 1 0 0 no change in binding to DNA or to certain proteins (NLI, PIT1, or MRG1) +DEPTOR DEPTOR Apoptosis Q8TB45 64798 8q24.12 human S298-p 4723873 SSSPTLSsSPPVLCN protein degradation; molecular association, regulation carcinogenesis, induced; apoptosis, inhibited; signaling pathway regulation mTOR(DISRUPTS) 19446321 3 3 1 PI3K-Akt signaling +MAP3K7 TAK1 EC 2.7.11.25; KINASE; Kinase, protein; Protein kinase, Ser/Thr (non-receptor); Protein kinase, TKL O43318 6885 6q15 human T344-p 969328000 QVPATNDtIKRLESK molecular association, regulation IKKG(INDUCES) 29511289 1 1 0 +ECE1 ECE1 iso3 Cell surface; EC 3.4.24.71; Membrane protein, integral; Protease; Vesicle P42892-3 1889 1p36.12 human T9-p 14159846 MSTYKRAtLDEEDLV protein stabilization cell motility, induced 26543229 1 7 8 colon cancer cell invasion. +SLC30A2 SLC30A2 Membrane protein, integral; Membrane protein, multi-pass; Transporter; Transporter, SLC family Q9BRI3 7780 1p36.11 human K6-ub 34666303 __MEAKEkQHLLDAR protein degradation; ubiquitination 25016022 1 0 0 zinc accumulation and secretion +CLTB CLTB Vesicle P09497 1212 5q35.2 human S205-p 25592003 LCDFNPKsSKQCKDV Clathrin_lg_ch endocytosis, induced CHCHD1(INDUCES) 22704991 1 0 0 discriminator for endocytosis of a subset of cargoes +Faah FAAH EC 3.5.1.99; Hydrolase; Membrane protein, integral O08914 14073 4 D1|4 53.08 cM mouse S241-p 34502044 LGTDIGGsIRFPSAF Amidase molecular association, regulation NLRP3(INDUCES) 36104448 1 3 0 +HSPA5 GRP78 Chaperone; Heat shock protein; KINASE P11021 3309 9q33.3 human K123-ac 13362604 PFKVVEKkTKPYIQV HSP70 molecular association, regulation; phosphorylation apoptosis, induced; signaling pathway regulation PERK(DISRUPTS) 20371724 1 1 0 induces phosphorylation of elf2a and activation of eIf2a-ATF4-CHOP pathway +CD44 CD44 Cell adhesion; Membrane protein, integral; Motility/polarity/chemotaxis; Receptor, misc. P16070 960 11p13 human S706-p 450988 LNGEASKsQEMVHLV activity, induced; molecular association, regulation; intracellular localization cell motility, altered; transcription, induced MMP9(DISRUPTS) 1281449; 19582779; 22865879; 9580567 12 58 37 nuclear localization +IRF5 IRF5 DNA-binding; Transcription factor Q13568 3663 7q32.1 human S435-p 26389900 EMFSGELsWSADSIR activity, induced; intracellular localization apoptosis, induced; transcription, induced 18836453; 22412986 3 1 0 +MAP4 MAP4 Cytoskeletal; Motility/polarity/chemotaxis P27816 4134 3p21.31 human K997-ac 6218845 GKVQIVSkKVSYSHI Tubulin-binding cytoskeletal reorganization 28002468 1 1 1 +KLF2 KLF2 C2H2-type zinc finger protein; DNA-binding Q9Y5W3 10365 19p13.11 human K122-sm 31089516 APPGRLVkAEPPEAD transcription, inhibited 23515309 1 1 0 +SIRT1 SIRT1 Apoptosis; DEACETYLASE; Deacetylase; EC 3.5.1.-; Nuclear receptor co-regulator Q96EB6 23411 10q21.3 human Y301-p 25311272 QAMFDIEyFRKDPRP SIR2 molecular association, regulation transcription, inhibited STAT3(INDUCES) 29789426 1 0 1 +HDAC1 HDAC1 DEACETYLASE; Deacetylase; EC 3.5.1.98; Hydrolase; Nuclear receptor co-regulator Q13547 3065 1p35.2-p35.1 human K439-ac 4219801 KNSSNFKkAKRVKTE enzymatic activity, inhibited transcription, inhibited 16762839 1 0 0 +ETV4 ETV4 DNA-binding P43268 2118 17q21.31 human K322-sm 3278908 EKFEGDIkQEGVGAF ETS_PEA3_N transcription, inhibited 17585876 1 0 0 +TBXA2R TXA2-R iso2 GPCR, family 1; Membrane protein, integral; Membrane protein, multi-pass; Receptor, GPCR P21731-2 6915 19p13.3 human T399-p 451396 LLPFEPPtGKALSRK receptor desensitization, altered 15100160 1 0 0 +SRY SRY DNA-binding; Nuclear receptor co-regulator Q05066 6736 Yp11.2 human K136-ac 12674406 YRPRRKAkMLPKNCS molecular association, regulation; intracellular localization cell differentiation, induced KPNB1(INDUCES) 15297880 1 0 0 +Slamf1 SLAM Membrane protein, integral; Receptor, misc. Q9QUM4 27218 1 H3|1 79.54 cM mouse Y315-p 448264 QDPCTTIyVAATEPA molecular association, regulation Fyn(INDUCES) 11477403 2 0 0 +RXRA RXRA DNA-binding; Motility/polarity/chemotaxis; Nuclear receptor P19793 6256 9q34.2 human T82-p 453096 HSMSVPTtPTLGFST Nuc_recep-AF1 molecular association, regulation carcinogenesis, induced; cell growth, induced; apoptosis, inhibited; transcription, inhibited SRC-1(DISRUPTS); RARB(DISRUPTS); RXRA(DISRUPTS) 17900311; 20432439 3 0 0 +BRD4 BRD4 KINASE; Kinase, protein; Protein kinase, Ser/Thr (non-receptor); Protein kinase, atypical O60885 23476 19p13.12 human T204-p 87391000 PNTTQAStPPQTQTP protein stabilization; molecular association, regulation; protein conformation transcription, induced CDK9(INDUCES); PIN1(INDUCES) 28481868 1 0 0 +NHERF1 NHERF Adaptor/scaffold; Motility/polarity/chemotaxis O14745 9368 17q25.1 human T156-p 3864004 ELRPRLCtMKKGPSG PDZ molecular association, regulation; intracellular localization cell growth, induced SKP2(INDUCES) 25492869; 26862730 2 0 2 promotes cell proliferation; increased nuclear localization +CDC25A CDC25A EC 3.1.3.48; Motility/polarity/chemotaxis; PHOSPHATASE; Protein phosphatase, dual-specificity P30304 993 3p21.31 human K169-ub 41483908 SHGLQEGkDLFTQRQ M-inducer_phosp intracellular localization 36539837 1 3 0 +Map3k4 MEKK4 EC 2.7.11.25; KINASE; Kinase, protein; Protein kinase, STE; Protein kinase, Ser/Thr (non-receptor) O08648 26407 17 8.42 cM|17 A1 mouse S492-p 468186 RKLERLEsEEDSIGW MEKK4_N molecular association, regulation; enzymatic activity, induced GADD45A(INDUCES) 27358404 1 21 18 +MAP3K11 MLK3 EC 2.7.11.25; KINASE; Kinase, protein; Protein kinase, Ser/Thr (non-receptor); Protein kinase, TKL Q16584 4296 11q13.1 human S789-p 487506 VSAGPRPsPLPSPQP enzymatic activity, induced apoptosis, induced 17711861 1 15 6 induces activation of itself and JNK +MEF2C MEF2C iso3 DNA-binding; Transcription factor Q06413-3 4208 5q14.3 human S387-p 1729600 TRHEAGRsPVDSLSS activity, induced transcription, altered 9069290; 9384584 3 2 0 +APP APP iso4 Apoptosis; Cell surface; Membrane protein, integral; Receptor, misc.; Transcription factor P05067-4 351 21q21.3 human S655-p 448200 LKKKQYTsIHHGVVE APP_amyloid protein processing exocytosis, altered 19381782 6 1 0 +Cacng2 Stargazin Channel, calcium; Membrane protein, integral; Membrane protein, multi-pass Q71RJ2 84347 7q34 rat T321-p 451273 NTANRRTtPV_____ molecular association, regulation PSD-95(INDUCES); PSD-95(DISRUPTS) 12122038; 19968761 3 0 0 +NEDD8 NEDD8 Ubiquitin-like modifier Q15843 4738 14q12 human K11-ac 33364162 KVKTLTGkEIEIDIE ubiquitin molecular association, regulation PARP1(INDUCES) 30804002 1 3 0 +FOXM1 FOXM1 iso2 DNA-binding; Transcription factor Q08050-2 2305 12p13.33 human K480-sm 31898507 PSPAPSFkEESSHSW protein degradation transcription, inhibited 25533473 2 0 0 +PLCG1 PLCG1 Carbohydrate Metabolism - inositol phosphate; EC 3.1.4.11; Motility/polarity/chemotaxis; Phospholipase P19174 5335 20q12 human Y783-p 447667 EGRNPGFyVEANPMP activity, induced; molecular association, regulation; intracellular localization; protein conformation; phosphorylation; enzymatic activity, induced carcinogenesis, inhibited; cell motility, induced; cell motility, altered; transcription, induced; cytoskeletal reorganization; signaling pathway regulation SLP76(INDUCES); GRB2(INDUCES); GADS(INDUCES); VEGFR2(INDUCES) 12029091; 16038803; 16525023; 17372230; 21760611; 22847294; 30131370; 30873169; 31196981; 33931484; 35124007; 35367415 92 42 558 +NR1H4 NR1H4 DNA-binding; Nuclear receptor Q96RI1 9971 12q23.1 human K167-ac 12159007 FFRRSITkNAVYKCK zf-C4 protein stabilization; molecular association, regulation transcription, inhibited RXRA(DISRUPTS) DNA(DISRUPTS) 19883617 1 1 0 +SCFD1 SCFD1 Vesicle Q8WVM8 23256 14q12 human K515-ac 1881937803 SYGSTTTkPMGLLSR autophagy, inhibited 35465820 1 1 0 SCFD1 deacetylation promotes SNARE complex formation +Id2 ID2 DNA-binding; Transcription, coactivator/corepressor P41136 15902 12 A1.3|12 8.57 cM mouse S14-p 4706868 VRSVRKNsLSDHSLG neural plasticity; cell growth, induced; transcription, altered 34599103 3 16 0 +OSMR OSMR Membrane protein, integral; Receptor, cytokine Q99650 9180 5p13.1 human Y917-p 1930200 AGETSLNyVSQLASP phosphorylation 18430728 2 0 0 important for STAT3 activation +HDAC1 HDAC1 DEACETYLASE; Deacetylase; EC 3.5.1.98; Hydrolase; Nuclear receptor co-regulator Q13547 3065 1p35.2-p35.1 human Y72-p 55375010 TKYHSDDyIKFLRSI Hist_deacetyl protein stabilization; intracellular localization apoptosis, inhibited 33976119 1 2 0 inhibits ubiquitination +RPS6KA3 RSK2 EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, AGC; Protein kinase, Ser/Thr (non-receptor) P51812 6197 Xp22.12 human S386-p 448065 HQLFRGFsFVAITSD Pkinase_C enzymatic activity, induced 37059179 14 19 59 +SEPTIN7 SEPT7 Cell cycle regulation; Cytoskeletal; Hydrolase Q16181 989 7p14.2 human T426-p 476328 EQQNSSRtLEKNKKK molecular association, regulation; intracellular localization 14-3-3 gamma(INDUCES) 35602601 2 56 46 +Btk Btk EC 2.7.10.2; KINASE; Kinase, protein; Protein kinase, TK; Protein kinase, tyrosine (non-receptor) P35991 12229 X E3|X 56.18 cM mouse S180-p 447577 GSLKPGSsHRKTKKP intracellular localization; activity, inhibited 11598012 2 4 0 +DUOX1 DUOX1 EC 1.6.3.1; Membrane protein, integral; Membrane protein, multi-pass; Oxidoreductase Q9NRD9 53905 15q21.1 human S1217-p 6370300 SHHFRRRsFRGFWLT Ferric_reduct enzymatic activity, inhibited 19144650 1 1 0 +KAT2B PCAF ACETYLTRANSFERASE; Acetyltransferase; EC 2.3.1.48; Nuclear receptor co-regulator Q92831 8850 3p24.3 human S264-p 1870426001 YWHLEAPsQRRLRSP PCAF_N molecular association, regulation; acetylation DNA(DISRUPTS) 32966758 1 0 0 inhibits histone acetylation thus stabilizing replication forks/ prevent excessive fork degradation +Relb RELB Transcription factor Q04863 19698 7 A3|7 9.93 cM mouse K273-ub 3055604 LSEPVYDkKSTNTSE RHD_DNA_bind transcription, induced 18620544 1 0 0 +PI4K2A PI4K2A EC 2.7.1.67; Kinase, lipid; Motility/polarity/chemotaxis Q9BTU6 55361 10q24.2 human S5-p 2022753 ___MDETsPLVSPER endocytosis, inhibited 37314927 2 12 0 +ID2 ID2 DNA-binding; Transcription, coactivator/corepressor Q02363 3398 2p25.1 human S5-p 451265 ___MKAFsPVRSVRK molecular association, regulation; protein stabilization; ubiquitination cell cycle regulation; cell growth, inhibited; transcription, altered APC(DISRUPTS) 26756672; 35440621 4 6 0 inhibits ubiquitination +BUB1B BUB1B EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, Other; Protein kinase, Ser/Thr (non-receptor); Tumor suppressor O60566 701 15q15.1 human K250-ac 7761217 IRVGGALkAPSQNRG protein stabilization; ubiquitination cell cycle regulation; carcinogenesis, inhibited 19407811; 22340495 5 1 0 +PHF2 PHF2 DEMETHYLASE; Demethylase; EC 1.14.11.-; Nucleolus O75151 5253 9q22.31 human S757-p 20936500 NARVKKEsGSSAAGI molecular association, regulation transcription, induced Mrf-2(INDUCES) DNA(INDUCES) 21532585 1 0 1 demethylation of Mrf-2 K336, complex is then targeted to promoters and removes repressive H3K9m2 +NF2 Merlin Cytoskeletal; Motility/polarity/chemotaxis; Tumor suppressor P35240 4771 22q12.2 human K387-ub 21178796 TADLLAEkAQITEEE ERM_helical molecular association, regulation; intracellular localization LATS1(DISRUPTS) 30918126 1 3 0 K63 kinked +NOS3 eNOS Amino Acid Metabolism - arginine and proline; EC 1.14.13.39; Oxidoreductase P29474 4846 7q36.1 human S1179-p 467802 RIRTQSFsLQERQLR enzymatic activity, induced apoptosis, inhibited 10973320; 33539947; 34499618 11 8 1 +Cpeb1 CPEB RNA-binding; Translation P70166 12877 7|7 D3 mouse S177-p 483983 DTRPILDsRSSSPSD CEBP1_N neural plasticity; cytoskeletal reorganization; translation, induced 17567800 3 2 0 spine density and shape, long-term depression and motor coordination +Tp53 p53 Activator; DNA-binding; Motility/polarity/chemotaxis; Nuclear receptor co-regulator; Transcription factor; Tumor suppressor P02340 22059 11 B3|11 42.83 cM mouse S373-p 447570 LKTKKGQsTSRHKKT acetylation 15794754 13 0 0 substitution of either alanine or aspartic acid at this site abrogated p53 acetylation at K379 (K382 in human) +Lepr LEPR Membrane protein, integral; Receptor, cytokine P48356 16847 4 C6|4 46.96 cM mouse Y1138-p 448434 SGENFVPyMPQFQTC activity, induced; molecular association, regulation; phosphorylation transcription, induced; signaling pathway regulation; transcription, altered SHP-2(INDUCES); STAT3(INDUCES) 10449753; 10799542; 11018044; 15634336; 18718905; 22768838; 24302741 16 0 0 mutation of this site (Y3F) inhibits JAK2/STAT3 pathway, which modulates energy homeostasis ; induces STAT3 phosphorylation and LEPR-STAT3 signaling +OSBP OSBP Lipid-binding P16258 rabbit Y396-p 2089800 DISLDEQyKHQLEET activity, induced 18230613 1 1 0 Y396F mutant inhibits oxysterol-mediated phosphorylation and activation of Stat3 +SIAH2 SIAH2 EC 6.3.2.-; EC 6.3.2.19; Ligase; Transcription, coactivator/corepressor; UBIQUITIN LIGASE; Ubiquitin conjugating system; Ubiquitin ligase O43255 6478 3q25.1 human S167-p 22878300 ICEYRPYsCPCPGAS Sina enzymatic activity, induced 21409570 1 0 0 +DNM1L DRP1 Apoptosis; EC 3.6.5.5; Endoplasmic reticulum; Hydrolase; Microtubule-binding; Mitochondrial; Motor O00429 10059 12p11.21 human S616-p 454690 PIPIMPAsPQKGHAV activity, induced; molecular association, regulation; acetylation; enzymatic activity, inhibited; intracellular localization; protein conformation; phosphorylation cell differentiation, inhibited; carcinogenesis, induced; carcinogenesis, inhibited; cell motility, induced; cell growth, inhibited; apoptosis, induced; transcription, induced; transcription, altered; signaling pathway regulation; autophagy, induced; exocytosis, induced; cell growth, induced; apoptosis, inhibited; cytoskeletal reorganization MFF(INDUCES); DRP1(INDUCES); Rab7(INDUCES) 21119009; 21646527; 25012575; 25658205; 28314909; 31308800; 31744518; 31949126; 31992853; 32433544; 33126710; 33476635; 33850055; 33850876; 33940381; 33941653; 34475379; 34534628; 34963686; 35100966; 35122996; 35332310; 35544764; 35686673; 35697120; 35739087; 36584588; 36759571; 36922509; 37232206; 37442283 132 78 114 +TAL1 TAL1 DNA-binding; Oncoprotein; Transcription factor P17542 6886 1p33 human S122-p 450663 DGRMVQLsPPALAAP protein degradation 11904294 2 10 85 +RCC1 RCC1 Cell cycle regulation; GEF; GEF, Ras P18754 1104 1p35.3 human S11-p 452007 KRIAKRRsPPADAIP molecular association, regulation; intracellular localization cell cycle regulation; cytoskeletal reorganization; cell growth, altered KPNA4(DISRUPTS) 15203004; 17855385; 18568422; 34356619 4 61 9 +PBK PBK Cancer Testis Antigen (CTA); EC 2.7.12.2; KINASE; Kinase, protein; Protein kinase, Other; Protein kinase, Ser/Thr (non-receptor); Protein kinase, dual-specificity (non-receptor) Q96KB5 55872 8p21.1 human Y74-p 473837 NPICNDHyRSVYQKR Pkinase protein stabilization; phosphorylation; enzymatic activity, induced cell cycle regulation; carcinogenesis, induced; cell growth, induced; apoptosis, inhibited; signaling pathway regulation 27016416; 31611604; 35546143; 35780928; 36167821 5 5 163 +SIM2 SIM2 DNA-binding; Motility/polarity/chemotaxis Q14190 6493 21q22.13 human S115-p 1385533600 ASVHLGLsQVELTGN PAS protein stabilization; molecular association, regulation BRCA1(INDUCES) 30531838 1 0 0 recruitment of RAD51 +Tp73 p73 DNA-binding; Transcription factor; Tumor suppressor Q9JJP2 22062 4 E2|4 83.79 cM mouse T11-p 7437802 TSSSSSStFEHLWSS molecular association, regulation transcription, induced p300(INDUCES) 19218448 1 0 0 +IRF7 IRF7 DNA-binding; Transcription factor Q92985 3665 11p15.5 human S487-p 1276100 LCLSSANsLYDDIEC transcription, inhibited 10893229 2 0 0 +NEK1 NEK1 EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, Other; Protein kinase, Ser/Thr (non-receptor) Q96PY6 4750 4q33 human T141-p 65958203 IFLTKDGtVQLGDFG Pkinase enzymatic activity, induced cell cycle regulation; carcinogenesis, induced; DNA repair, induced; cell growth, induced; apoptosis, induced; transcription, induced 28426283; 30928383 3 0 0 +Mef2d MEF2D DNA-binding; Transcription factor Q63943 17261 3 F1|3 38.78 cM mouse S121-p 2246700 EDKYRRAsEELDGLF HJURP_C protein stabilization; molecular association, regulation; protein conformation; activity, inhibited cell differentiation, altered; transcription, inhibited HDAC9(INDUCES); ASH2L(DISRUPTS); HDAC4(INDUCES) 18299387; 23723416 3 33 9 +H4-16 H4 DNA-binding NP_001139343 530773 cow K12-ac 459013 KGGKGLGkGGAKRHR methylation cell cycle regulation 18698155 93 25 531 complex relationship of acetylation and methylation of CpG dinucleotides on DNA, during development of gametogenesis and embryogenesis +PKM PKM Carbohydrate Metabolism - glycolysis and gluconeogenesis; Carbohydrate Metabolism - pyruvate; EC 2.7.1.40; KINASE; Kinase, other; Mitochondrial; Nucleotide Metabolism - purine P14618 5315 15q23 human S202-p 15721963 TEVENGGsLGSKKGV PK molecular association, regulation; intracellular localization STAT5A(INDUCES) 27340866 1 7 0 nuclear localization +BHLHE41 BHLHB3 Q9C0J9 79365 12p12.1 human K266-sm 31094508 GASRVTIkQEPPGED molecular association, regulation; methylation cell differentiation, inhibited; chromatin organization, altered; transcription, inhibited EHMT2(INDUCES) 23637228 1 0 0 induces histone dimethylation, induces recruitment of EHMT2 to promoters through binding to EHMT2 +Irs1 IRS1 Adaptor/scaffold; Motility/polarity/chemotaxis P35570 25467 9q34 rat Y895-p 447556 EPKSPGEyVNIEFGS molecular association, regulation; phosphorylation signaling pathway regulation GRB2(INDUCES); SHP-2(INDUCES) 33824679; 7504175; 8196603 13 2 0 regulates the insulin pathway; induces MAPK activation/phosphorylation +Dync1li2 DNCLI2 Motility/polarity/chemotaxis Q6PDL0 234663 8 D3|8 53.04 cM mouse T202-p 4739826 PQRRGPLtSGSDEDS DLIC carcinogenesis, induced 33414172 1 3 0 +ABCA1 ABCA1 Membrane protein, integral; Membrane protein, multi-pass; Transporter; Transporter, ABC family; Vesicle O95477 19 9q31.1 human S2054-p 455498 GGNKRKLsTAMALIG ABC_tran activity, induced; ubiquitination 12196520; 26494466 2 0 0 +ANP32B ANP32B Chaperone Q92688 10541 9q22.33 human T244-p 456786 GEKRKREtDDEGEDD intracellular localization transcription, altered 17178712; 19130553 2 49 176 regulates the nucleocytoplasmic translocation of CD83 mRNA and its expression; leads to the translocation of the protein from the nucleus to the cytoplasm; required for efficient CD83 expression +MAPK1 ERK2 EC 2.7.11.24; KINASE; Kinase, protein; Protein kinase, CMGC; Protein kinase, Ser/Thr (non-receptor) P28482 5594 22q11.22 human S248-p 6845000 LGILGSPsQEDLNCI Pkinase molecular association, regulation; intracellular localization; phosphorylation cell growth, induced IPO7(INDUCES); NUP153(DISRUPTS) 18760948; 21730285 2 0 0 +CEBPA C/EBP-alpha DNA-binding; Transcription factor P49715 1050 19q13.11 human R156-m2 1878324501 RVGAPALrPLVIKQE cell cycle regulation; carcinogenesis, induced; cell growth, induced; transcription, inhibited HDAC3(DISRUPTS) 31015230 1 1 0 +H4-16 H4 DNA-binding NP_001139343 530773 cow K8-ac 458959 SGRGKGGkGLGKGGA methylation cell cycle regulation 18698155 85 21 529 complex relationship of acetylation and methylation of CpG dinucleotides on DNA, during development of gametogenesis and embryogenesis +GRK2 GRK2 EC 2.7.11.15; KINASE; Kinase, protein; Protein kinase, AGC; Protein kinase, Ser/Thr (non-receptor) P25098 156 11q13.2 human Y92-p 456873 FYEEIKKyEKLETEE RGS protein degradation; molecular association, regulation G-alpha(q)(INDUCES) 11566877; 16725308 5 0 0 +FBXO31 FBXO31 Cell cycle regulation; UBIQUITIN LIGASE; Ubiquitin conjugating system; Ubiquitin ligase Q5XUX0 79791 16q24.2 human S278-p 13216200 LMKFIYTsQYDNCLT molecular association, regulation; protein stabilization CDH1(DISRUPTS); CDC20(DISRUPTS) 19412162; 29343641 2 0 0 +EIF3A eIF3-theta RNA-binding; Translation; Translation initiation Q14152 8661 10q26.11 human S584-p 471999 ERKERLEsLNIQREK translation, induced 30001349 1 35 17 +Jak2 JAK2 EC 2.7.10.2; KINASE; Kinase, protein; Oncoprotein; Protein kinase, TK; Protein kinase, tyrosine (non-receptor) Q62120 16452 19 C1|19 23.73 cM mouse Y966-p 462255 QICKGMEyLGTKRYI PK_Tyr_Ser-Thr enzymatic activity, induced 20304997 3 3 3 +GNAZ G-alpha(z) Endoplasmic reticulum; G protein, heterotrimeric; G protein, heterotrimeric alpha G((i/o/t/z)); Nuclear envelope P19086 2781 22q11.22-q11.23 human S27-p 451241 DRHLRSEsQRQRREI G-alpha activity, induced; protein conformation 10686433; 9166747 4 0 2 +RET Ret EC 2.7.10.1; KINASE; Kinase, protein; Membrane protein, integral; Oncoprotein; Protein kinase, TK; Protein kinase, tyrosine (receptor) P07949 5979 10q11.21 human K1060-ub 31839905 PSTWIENkLYGMSDP protein degradation; phosphorylation 24425877 1 0 0 Y341 phosphorylation increases Ret ubquitylation +IRF3 IRF3 DNA-binding; Transcription factor Q14653 3661 19q13.33 human K315-ub 56403900 DGEVPKDkEGGVFDL IRF-3 intracellular localization apoptosis, induced 27178468 1 0 0 +Krt8 K8 Cytoskeletal P11679 16691 15 F2|15 57.2 cM mouse S431-p 31880611 GYSGGLSsSYGGLTS carcinogenesis, induced 33847415 1 4 1 +HCFC1 HCFC1 Transcription, coactivator/corepressor P51610 3054 Xq28 human K1807-ub 6423511 PPSKAPMkKENQWFD protein stabilization cell cycle regulation; cell growth, induced 19188440 1 1 0 +Fzd3 FZD3 GPCR, Fz/Smo family; Membrane protein, integral; Membrane protein, multi-pass; Receptor, GPCR Q61086 14365 14 D1|14 34.09 cM mouse T542-p 18507004 SLLRDPNtPIIRKSR receptor internalization, inhibited; phosphorylation endocytosis, inhibited 21316586 1 0 2 enhances PCP signaling, regulating c-Jun phosphorylation, and affecting growth cone guidance +JAK2 JAK2 EC 2.7.10.2; KINASE; Kinase, protein; Oncoprotein; Protein kinase, TK; Protein kinase, tyrosine (non-receptor) O60674 3717 9p24.1 human T174-p 56527200 KVPVTHEtQEECLGM FERM_F2 enzymatic activity, induced transcription, induced 27368100 1 1 0 STAT3 activity induced +Ets1 Ets-1 DNA-binding; Motility/polarity/chemotaxis; Oncoprotein; Transcription factor P27577 23871 9 A4|9 17.97 cM mouse S251-p 449316 GKLGGQDsFESVESY Ets1_N_flank molecular association, regulation; acetylation; intracellular localization transcription, inhibited DNA(DISRUPTS) 30865889 4 13 1 induce acetylation of FOXO1 and suppress gluconeogenesis +SLC25A4 SLC25A4 Membrane protein, integral; Membrane protein, multi-pass; Mitochondrial; Transporter; Transporter, SLC family P12235 291 4q35.1 human K23-ac 25541520 GVAAAVSkTAVAPIE Mito_carr; TM molecular association, regulation 34332952 0 5 0 Acetylation at K23 reduces binding of SLC25A4 to ADP. +BSG BSG Immunoglobulin superfamily; Membrane protein, integral P35613 682 19p13.3 human K350-ub 15385438 FIYEKRRkPEDVLDD carcinogenesis, induced; cell motility, induced; cell growth, induced; transcription, induced 26769849 1 5 3 +CENPJ CENPJ Cell cycle regulation; Microtubule-binding; Transcription, coactivator/corepressor Q9HC77 55835 13q12.12-q12.13 human S1109-p 460560 NPPRRSKsAPPRDLG molecular association, regulation 14-3-3 gamma(INDUCES) 16516142 1 3 0 association with 14-3-3 decreases in mitotic cells +SRC Src EC 2.7.10.2; KINASE; Kinase, protein; Oncoprotein; Protein kinase, TK; Protein kinase, tyrosine (non-receptor) P12931 6714 20q11.23 human S17-p 448231 DASQRRRsLEPAENV enzymatic activity, induced 12221082 10 46 12 Src S16 phosphorylation is necessary and sufficient for Rap1 and Ras activation by isoproterenol. +Rasgrp2 RASGRP2 GEF; GEF, Ras Q9QUG9 19395 19|19 A mouse S554-p 4781198 ECRRRAQsVSLEGSA activity, induced; molecular association, regulation 14-3-3 beta(INDUCES) 26804993 1 5 36 +Src Src EC 2.7.10.2; KINASE; Kinase, protein; Oncoprotein; Protein kinase, TK; Protein kinase, tyrosine (non-receptor) Q9WUD9 83805 3q42 rat Y530-p 448235 FTSTEPQyQPGENL_ molecular association, regulation; enzymatic activity, inhibited cell adhesion, altered PTPRA(INDUCES) 15735685; 36034878 153 24 968 +Brsk2 BRSK2 EC 2.7.11.1; EC 2.7.11.26; KINASE; Kinase, protein; Protein kinase, CAMK; Protein kinase, Ser/Thr (non-receptor) Q69Z98 75770 7|7 F5 mouse S490-p 2085948 IKNSFLGsPRFHRRK protein stabilization; enzymatic activity, inhibited; phosphorylation 23790753 1 30 3 inhibits axon branching (activated in BRSK2 18A mutant) +GOLPH3 GOLPH3 Mitochondrial Q9H4A6 64083 5p13.3 human T143-p 31834909 ALKHVKEtQPPETVQ GPP34 activity, induced; molecular association, regulation DNA repair, induced; signaling pathway regulation MYO18A(INDUCES) 24485452 1 1 0 DNA-PK/GOLPH3/MYO18A pathway, Increased phosphorylation leads to DNA-damage-induced Golgi dispersion +AURKA AurA EC 2.7.11.1; KINASE; Kinase, protein; Oncoprotein; Protein kinase, Other; Protein kinase, Ser/Thr (non-receptor) O14965 6790 20q13.2 human K125-ac 1873284340 QKNEESKkRQWALED enzymatic activity, induced cell cycle regulation; carcinogenesis, induced; cell motility, induced; cell growth, induced 28915666 1 0 0 may lead to development of cancer +GYS1 GYS1 Carbohydrate Metabolism - starch and sucrose; EC 2.4.1.11; Transferase P13834 100008660 rabbit S649-p 448239 VPPSPSLsRHSSPHQ Glycogen_syn enzymatic activity, inhibited 10909964; 6402364 14 15 1 activated by insulin treatment +Lyn LYN EC 2.7.10.2; KINASE; Kinase, protein; Oncoprotein; Protein kinase, TK; Protein kinase, tyrosine (non-receptor) P25911 17096 4 A1|4 2.05 cM mouse Y397-p 448695 RVIEDNEyTAREGAK PK_Tyr_Ser-Thr enzymatic activity, induced carcinogenesis, induced; cell motility, induced; cell growth, induced Bcr(NOT_REPORTED) 10415030; 21636860; 35150959 34 61 2054 +GAPDH GAPDH Carbohydrate Metabolism - glycolysis and gluconeogenesis; EC 1.2.1.12; Oxidoreductase P04406 2597 12p13.31 human S98-p 52434703 GAEYVVEsTGVFTTM Gp_dh_N enzymatic activity, induced 26629320 1 1 0 +Nos1 nNOS Amino Acid Metabolism - arginine and proline; EC 1.14.13.39; Oxidoreductase P29476 24598 12q16 rat K856-ac 2459109 SSYSDSRkSSGDGPD Flavodoxin_1 activity, induced 18415985 1 1 0 +IQGAP2 IQGAP2 G protein regulator, misc.; Motility/polarity/chemotaxis Q13576 10788 5q13.3 human T716-p 18964300 EYMHRRQtFIDNTDS molecular association, regulation; intracellular localization cytoskeletal reorganization RAC1(INDUCES); AKAP11(INDUCES) 21460214; 21776420 2 2 0 recruitment of active Rac to the complex, membrane ruffling; membrane ruffles +CEP192 CEP192 Cell cycle regulation; Microtubule-binding Q8TEP8 55125 18p11.21 human T44-p 41159607 GLPVAVStLARDRSS molecular association, regulation cell cycle regulation; cytoskeletal reorganization PLK1(INDUCES) 26012549 1 0 0 required for proper spindle formation and mitotic progression +CALCOCO2 CALCOCO2 Calcium-binding Q13137 10241 17q21.32 human T39-p 1336919200 YIPGGDVtCHYTFTQ SKICH autophagy, altered 30459273 1 0 0 +VRK1 VRK1 EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, CK1; Protein kinase, Ser/Thr (non-receptor) Q99986 7443 14q32.2 human S342-p 5938010 DDGKLDLsVVENGGL cytoskeletal reorganization 19103756 2 5 0 necessary for Golgi fragmentation +HK1 HK1 Carbohydrate Metabolism - amino sugar and nucleotide sugar; Carbohydrate Metabolism - fructose and mannose; Carbohydrate Metabolism - galactose; Carbohydrate Metabolism - glycolysis and gluconeogenesis; Carbohydrate Metabolism - starch and sucrose; EC 2.7.1.1; Kinase, other; Mitochondrial P19367 3098 10q22.1 human S364-p 55569801 TRLGVEPsDDDCVSV Hexokinase_2 enzymatic activity, induced 27153534 1 1 0 +Ntrk2 TrkB EC 2.7.10.1; KINASE; Kinase, protein; Membrane protein, integral; Protein kinase, TK; Protein kinase, tyrosine (receptor) Q63604 25054 17p14 rat S478-p 478364 SNDDDSAsPLHHISN cytoskeletal reorganization 17341134 2 1 0 dendritic growth +RIPK1 RIPK1 EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, Ser/Thr (non-receptor); Protein kinase, TKL Q13546 8737 6p25.2 human K530-ac 27992509 PPTDESIkYTIYNST RHIM molecular association, regulation RIPK3(DISRUPTS) 23201684 1 1 0 +Trarg1 TUSC5 Membrane protein, integral; Membrane protein, multi-pass Q8C838 237858 11|11 B5 mouse S76-p 7829266 PSLSGSPsRVSSRRA intracellular localization 35594055 1 3 1 regulates GLUT4 translocation +Map1b MAP1B Cytoskeletal; Motility/polarity/chemotaxis P14873 17755 13 D1|13 52.9 cM mouse S1260-p 454136 SLSPSPPsPIEKTPL cytoskeletal reorganization 15731007 3 71 17 induces a loss of stable microtubules +Tnp2 TP2 DNA-binding P11101 24840 10q11 rat K91-ac 3613758 TLEGKVSkRKAVRRR TP2 molecular association, regulation chromatin organization, altered NPM3(DISRUPTS) 19710011 2 2 1 +Myod1 MyoD DNA-binding; RNA splicing; Transcription factor P10085 17927 7 B3|7 30.03 cM mouse K133-ub 7761226 NEAFETLkRCTSSNP HLH protein degradation 19319192 1 0 0 regulation of skeletal muscle myotube atrophy +Syt1 SYT1 Calcium-binding; Membrane protein, integral; Vesicle P21707 25716 7q21 rat T195-p 1878260800 DKKKKFEtKVHRKTL molecular association, regulation exocytosis, inhibited SNAP-25(DISRUPTS) 35914553 1 0 0 +Atad3 ATAD3A Mitochondrial Q925I1 108888 4|4 E2 mouse K134-ac 11322823 ARAQYQDkLARQRYE ATAD3_N molecular association, regulation; activity, inhibited ATAD3A(DISRUPTS) 30914652 1 3 1 dimerization of ATAD3A is promoted by deacetylation of ATAD3A and Drp1-mediated mitochondrial fragmentation +PLAGL2 PLAGL2 C2H2-type zinc finger protein; DNA-binding Q9UPG8 5326 20q11.21 human K269-sm 483050 CSSTVSVkEELSPVL intracellular localization cell growth, induced; transcription, inhibited 16207715 3 0 0 +PHF2 PHF2 DEMETHYLASE; Demethylase; EC 1.14.11.-; Nucleolus O75151 5253 9q22.31 human S655-p 3175945 KALRPPTsPGVFGAL carcinogenesis, inhibited; cell motility, inhibited 36872368 2 14 1 AMPKA2 induced PHF2-S655 phosphorylation suppresses cell migration, invasion, and metastasis. +DAPK3 DAPK3 EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, CAMK; Protein kinase, Ser/Thr (non-receptor); Tumor suppressor O43293 1613 19p13.3 human T225-p 454891 LGETKQEtLTNISAV Pkinase enzymatic activity, induced 15611134 2 0 0 +SNAI2 Snail2 Apoptosis; C2H2-type zinc finger protein; Motility/polarity/chemotaxis; Transcription factor O43623 6591 8q11.21 human S251-p 63243400 KNCSKTFsRMSLLHK zf-C2H2 intracellular localization transcription, induced 28288135 1 0 0 nuclear localization +Marcks MARCKS Actin-binding; Motility/polarity/chemotaxis P26645 17118 10 B1|10 19.49 cM mouse S156-p 447787 KRFSFKKsFKLSGFS MARCKS receptor internalization, induced; intracellular localization carcinogenesis, induced; cell motility, altered 20211725; 34556581 24 30 7 +Taok1 TAO1 EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, STE; Protein kinase, Ser/Thr (non-receptor) Q5F2E8 216965 11|11 B5 mouse T440-p 23150854 RNREHFAtIRTASLV molecular association, regulation cytoskeletal reorganization MYL5(INDUCES); DBN1(INDUCES) 25456499 2 2 1 spine development +Aurkb AurB EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, Other; Protein kinase, Ser/Thr (non-receptor) O70126 20877 11 B3|11 42.32 cM mouse K103-ub 40212804 VYLAREKkSRFIVAL Pkinase protein degradation cell cycle regulation; carcinogenesis, inhibited; apoptosis, induced 23928698 1 1 0 +DNMT3A DNMT3A Amino Acid Metabolism - cysteine and methionine; EC 2.1.1.37; METHYLTRANSFERASE; Methyltransferase; Methyltransferase, DNA Q9Y6K1 1788 2p23.3 human R882-me 1877292601 TDVSNMSrLARQRLL molecular association, regulation; methylation; enzymatic activity, induced cell differentiation, induced; transcription, altered DNMT3A(DISRUPTS) DNA(DISRUPTS) 31076446; 31582562 5 0 0 DNA binding using fluorescence polarization, R882H mutation causes a reduction in DNA methyltransferase activity, and stabilizes the formation of large oligomers reducing activity, ; R882 mutants R882 showed DNA methylation of CpGs were significantly lower at HLF transcription start sites as compared to controls. +CASP2 CASP2 Apoptosis; EC 3.4.22.55; Protease P42575 835 7q34 human S340-p 10892800 DGKNHAGsPGCEESD Peptidase_C14 apoptosis, altered 19730412 1 12 0 +ZMYM2 ZNF198 Transcription factor Q9UBW7 7750 13q12.11 human S309-p 17434113 DSLSPVAsLPKQIFQ molecular association, regulation; ubiquitination HDAC1(DISRUPTS); LSD1(DISRUPTS) 25855382 1 3 0 +PKP1 plakophilin 1 Cell adhesion; Motility/polarity/chemotaxis Q13835 5317 1q32.1 human S188-p 15413421 QNRYSFYsTCSGQKA activity, induced; protein stabilization cell motility, induced; cell growth, induced; translation, induced; cell adhesion, inhibited 23444369 1 2 7 +SNAI1 Snail1 C2H2-type zinc finger protein; Transcription factor O95863 6615 20q13.13 human S96-p 455883 TSLSDEDsGKGSQPP protein degradation; ubiquitination; intracellular localization cell motility, altered; transcription, altered FBW1B(INDUCES) 15448698; 15647282; 19004823 4 1 0 Localization mediated by S107, S111, S115 and S119. +Scn2a SCN2A Channel, sodium; Membrane protein, integral; Membrane protein, multi-pass P04775 24766 3q21 rat Y1498-p 1046200 TEEQKKYyNAMKKLG activity, inhibited 17959797 1 0 0 +DAXX DAXX Apoptosis; Nuclear receptor co-regulator; Nucleolus; Transcription, coactivator/corepressor Q9UER7 1616 6p21.32 human S184-p 10438000 QSPRTRGsRRQIQRL protein stabilization; ubiquitination apoptosis, induced 19789334; 19789335 2 0 0 required for TNF alpha -dependent accumulation of Daxx in cells ; phosphorylation induces K63-linked polyubiquitination of DAXX at K122 +EP300 p300 ACETYLTRANSFERASE; Acetyltransferase; EC 2.3.1.48; Motility/polarity/chemotaxis; Nuclear receptor co-regulator; Transcription, coactivator/corepressor Q09472 2033 22q13.2 human S106-p 14652802 GPGQVMAsQAQQSSP molecular association, regulation; acetylation; protein stabilization; enzymatic activity, induced NBS1(INDUCES) 20471956; 21108945 3 0 0 required for NBS1 stability; regulates stability of NBS1 and its recruitment into damaged DNA +TERT TERT iso3 DNA-binding; EC 2.7.7.49; Nucleolus; Transferase O14746-3 7015 5p15.33 human K329-ub 14561003 PPVYAETkHFLYSSG protein degradation chromatin organization, altered; apoptosis, induced 20453884 1 0 0 +RUNX1 AML1 iso8 DNA-binding; Oncoprotein; Transcription factor Q01196-8 861 21q22.12 human R233-me 2363103 SELEQLRrTAMRVSP apoptosis, induced; transcription, induced 32573733 2 1 0 +Cacna1b CACNA1B Channel, calcium; Membrane protein, integral; Membrane protein, multi-pass Q02294 257648 3p13 rat S898-p 455281 ARPRRSHsKEAPGAD activity, inhibited 11312277 2 2 0 Phosphorylation by PKC prevents effects of syntaxin 1A on voltage dependent inactivation of N-type calcium channels. +PRKDC DNAPK DNA repair, damage; EC 2.7.11.1; KINASE; Kinase, protein; Nucleolus; Protein kinase, Ser/Thr (non-receptor); Protein kinase, atypical P78527 5591 8q11.21 human S3205-p 452351 TPLPEDNsMNVDQDG FAT intracellular localization cell cycle regulation; DNA repair, induced 24844881; 32674014 4 29 4 +IGF1R IGF1R EC 2.7.10.1; KINASE; Kinase, protein; Membrane protein, integral; Protein kinase, TK; Protein kinase, tyrosine (receptor) P08069 3480 15q26.3 human Y1280-p 450101 GFREVSFyYSEENKL cell differentiation, altered; cell growth, altered 10786694 5 0 0 observed in quadruple mutant Y980/1280/1281/1346F +NBN NBS1 Cell cycle regulation; DNA repair, damage O60934 4683 8q21.3 human S278-p 449968 VDTGITNsQTLIPDC NIBRIN_BRCT_II phosphorylation cell cycle regulation; apoptosis, induced; chromatin organization, altered 12861053; 14707289; 18003706; 18644472 10 0 0 phosphorylation of RFA2; important for apoptosis induction; S phase checkpoint; telomere maintenance +RXRA RXRA DNA-binding; Motility/polarity/chemotaxis; Nuclear receptor P19793 6256 9q34.2 human S66-p 333674900 NGMGPPFsVISSPMG Nuc_recep-AF1 ubiquitination 29137318 1 0 0 negatively regulated beta-catenin expression by ubiquitination of ?-catenin in CRC +Prkcz PKCZ EC 2.7.11.13; KINASE; Kinase, protein; Protein kinase, AGC; Protein kinase, Ser/Thr (non-receptor) P09217 25522 5q36 rat T410-p 447510 GPGDTTStFCGTPNY Pkinase protein degradation; intracellular localization; enzymatic activity, induced cytoskeletal reorganization; transcription, altered TNNI1(INDUCES); desmin(INDUCES); TPM1(INDUCES); MYO1C(INDUCES); TNNT1(INDUCES) 11141077; 11222751; 14580237; 17724026 45 3 10 +Gata1 GATA1 DNA-binding; Transcription factor P17679 14460 X A1.1|X 3.59 cM mouse K245-ac 466357 NRPLIRPkKRMIVSK protein degradation; acetylation; ubiquitination; phosphorylation DNA(INDUCES) 16858405 3 1 0 Phosphorylation and acetylation cause the degradation of acetylated GATA-1; acetylation of GATA-1 causes ubiquitination; DNA binding is required for MAPK-dependent phosphorylation +NDRG1 NDRG1 Cell development/differentiation; Vesicle Q92597 10397 8q24.22 human K14-sm 40320202 DVDLAEVkPLVEKGE protein degradation; ubiquitination 25712528 1 1 0 promotes downregulation of p21 expression +FLJ33534 FLJ33534 Unknown function Q8N2B8 285150 2p25.1 human K124-ub 52485011 QILGSTLkLFRHPPS protein degradation 26676607 0 1 0 +GABBR1 GABBR1 GPCR, family 3; Membrane protein, integral; Membrane protein, multi-pass; Receptor, GPCR Q9UBS5 2550 6p22.1 human Y230-p 3436001 GQATKYLyELLYNDP ANF_receptor molecular association, regulation; phosphorylation carcinogenesis, induced; cell growth, induced; signaling pathway regulation PTP-PEST(INDUCES) 34778730 1 0 1 binding to PTP-PEST inhibits PTP-PEST binding to EGFR, induces EGFR phosphorylation, thus regulating AKT signaling +APP APP Apoptosis; Cell surface; Membrane protein, integral; Receptor, misc.; Transcription factor P05067 351 21q21.3 human K751-ne 12124800 PEERHLSkMQQNGYE APP_amyloid transcription, inhibited Fe65(DISRUPTS) 18096514 1 0 0 +STAT3 STAT3 DNA-binding; Motility/polarity/chemotaxis; Nuclear receptor co-regulator; Transcription factor P40763 6774 17q21.2 human K49-ac 461010 DWAYAASkESHATLV STAT_int activity, induced; molecular association, regulation; intracellular localization transcription, induced p300(INDUCES) 16285960; 18782771 3 1 0 affects nuclear-cytoplasmic redistribution of the protein; induces enhanceosome formation +CDH5 CDH5 Cell adhesion; Membrane protein, integral; Motility/polarity/chemotaxis P33151 1003 16q21 human S665-p 2562900 YDVSVLNsVRRGGAK intracellular localization 18194650 3 0 0 +CALR Calreticulin ACETYLTRANSFERASE; Acetyltransferase; Calcium-binding; Motility/polarity/chemotaxis; Nuclear receptor co-regulator; Secreted; Secreted, signal peptide P27797 811 19p13.13 human K153-ac 4219808 VIFNYKGkNVLINKD Calreticulin protein conformation 18795239 1 1 0 +IFIH1 MDA5 Apoptosis; EC 3.6.4.13; Helicase Q9BYX4 64135 2q24.2 human K865-sm 63243405 IHCVQNMkPEEYAHK phosphorylation 28250012 1 0 0 dephosphorylation +RPTOR Raptor Adaptor/scaffold Q8N122 57521 17q25.3 human T706-p 11315002 TTEGGSLtPVRDSPC intracellular localization; enzymatic activity, induced cell cycle regulation 21900751; 22493283 8 9 0 +DIPK1C DIPK1C Membrane protein, integral Q0P6D2 125704 18q22.3 human S51-p 1877626502 RAHPGVLsERCTDEK PIP49_N neural plasticity; apoptosis, inhibited 35858575 1 1 0 +SRPK1 SRPK1 EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, CMGC; Protein kinase, Ser/Thr (non-receptor) Q96SB4 6732 6p21.31 human T326-p 25724401 ENPPNKMtQEKLEES intracellular localization RNA splicing, induced 22727668; 33808326 2 1 0 translocation to the nucleus-regulation of E1A splicing +TTK TTK Cancer Testis Antigen (CTA); EC 2.7.12.1; KINASE; Kinase, protein; Protein kinase, Other; Protein kinase, dual-specificity (non-receptor) P33981 7272 6q14.1 human T675-p 487539 ANQMQPDtTSVVKDS Pkinase activity, induced; enzymatic activity, inhibited cell cycle regulation; chromatin organization, altered 18680479; 31511308 5 2 0 microtubule?kinetochore attachment; in vitro +BACH2 BACH2 DNA-binding; Transcription factor Q9BYV9 60468 6q15 human K276-sm 2798317 GLARGQIkSEPPSEE intracellular localization 18201693 2 0 0 mobility of nuclear domains +TRIM32 TRIM32 EC 6.3.2.-; EC 6.3.2.19; Ligase; UBIQUITIN LIGASE; Ubiquitin conjugating system; Ubiquitin ligase Q13049 22954 9q33.1 human S339-p 3195098 VVASPRAsPAKQRGP intracellular localization cell growth, inhibited 25100564 2 19 0 promotes Asymmetric Cell Division +OTULIN FAM105B EC 3.4.19.12 Q96BN8 90268 5p15.2 human K66-ub 12317109 ADEIEKEkELLIHER protein conformation FAM105B(INDUCES) 35939695 1 6 8 genotoxic stress induces FAM105B dimerization, FAM105B self-deubiquitination, NF-kB Activation +Rps6kb1 p70S6K iso2 EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, AGC; Protein kinase, Ser/Thr (non-receptor); Translation P67999-2 83840 10q26 rat S424-p 448357 GSPRTPVsPVKFSPG activity, induced cell growth, altered 16195541 102 54 247 PI3K, Akt and mTOR activation are required for 5-HT-induced proliferatioin. Wortmanin LY294002 and NL-71-101 dose-dependently inhibited 5HT induced proliferation. +CEBPD C/EBP-delta DNA-binding; Motility/polarity/chemotaxis P49716 1052 8q11.21 human K120-sm 3496602 PAAPRLLkREPDWGD molecular association, regulation transcription, inhibited p300(DISRUPTS) 16397300 2 0 0 +DLGAP1 SAPAP1 iso2 Cytoskeletal O14490-2 9229 18p11.31 human S191-p 480585 CFRMRSHsYVRAIEK molecular association, regulation PSD-95(DISRUPTS) 23143515 2 2 4 +Snap23 SNAP23 Vesicle O70377 64630 3q35 rat S120-p 455263 NVVSKQPsRITNGQP SNAP-25 molecular association, regulation; intracellular localization exocytosis, inhibited; exocytosis, altered STX17(INDUCES) 20967886; 29485121; 33213278 9 2 0 mediates the movem ent of SNAP-23 to internal locations and then its association with lysosomal membranes, SNAP-23 membrane association dynamics and subsequently MC degranulation +MAPRE1 EB1 Cytoskeletal; Motility/polarity/chemotaxis Q15691 22919 20q11.21 human T154-p 31883043 NKPKKPLtSSSAAPQ molecular association, regulation; protein conformation cytoskeletal reorganization Restin(INDUCES); dynactin 1(INDUCES); TUBB(INDUCES) 27721984; 28039481 2 2 0 astral microtubule stability ; regulating astral microtubule stability and spindle orientation/positioning +RGS18 RGS18 GAP; GAP, RGS Q9NS28 64407 1q31.2 human S49-p 451167 KEKRNRLsLLVQKPE molecular association, regulation signaling pathway regulation 14-3-3 gamma(INDUCES) 22234696; 24244663 3 5 0 Ca 2+ signaling +TET1 TET1 DNA-binding; EC 1.14.11.n2; Oxidoreductase Q8NFU7 80312 10q21.3 human S1971-p 1881549502 SEADEPPsDEPLSDD protein stabilization carcinogenesis, induced; cell growth, induced; apoptosis, inhibited; transcription, induced 36989375 1 0 0 +ABCA4 ABCA4 Membrane protein, integral; Membrane protein, multi-pass; Transporter; Transporter, ABC family P78363 24 1p22.1 human T901-p 20940701 LEKTEPLtEETEDPE protein stabilization; protein conformation 21721517 1 1 0 +SPAG5 SPAG5 Cell cycle regulation Q96R06 10615 17q11.2 human K409-ub 53415401 QTGLVGTkHSTSETE protein degradation; intracellular localization cell cycle regulation; cytoskeletal reorganization 26748699 1 3 0 regulation of cell division and cytokinesis +FANCI FANCI Cell cycle regulation; DNA repair, damage Q9NVI1 55215 15q26.1 human S559-p 11952935 SLSSSQCsQSLSVSQ FANCI_HD2 molecular association, regulation; ubiquitination DNA repair, induced; cell growth, inhibited FANCD2(INDUCES); MCM5(DISRUPTS) DNA(INDUCES) 25843623; 28636932; 32117957 4 2 0 prevents deubiquitination of FANCD2; inhibits dormant origin firing +PARVA PARVA Adaptor/scaffold; Motility/polarity/chemotaxis Q9NVD7 55742 11p15.3 human S8-p 4270099 MATSPQKsPSVPKSP molecular association, regulation; enzymatic activity, induced cell motility, induced; cell adhesion, induced ARHGEF7(INDUCES); PAK1(INDUCES) 15353548; 22955285 4 33 0 Matrix degradation, Src and MMP2 activity +LMNA lamin A/C Cytoskeletal P02545 4000 1q22 human S652-p 452607 SYLLGNSsPRTQSPQ activity, induced; intracellular localization 18815303 2 22 0 nuclear lamin disassemby +DYRK2 DYRK2 iso2 EC 2.7.12.1; KINASE; Kinase, protein; Protein kinase, CMGC; Protein kinase, dual-specificity (non-receptor) Q92630-2 8445 12q15 human S497-p 1874397818 ISKLPPPsSSASKLR cell cycle regulation; apoptosis, induced 34363019 1 1 0 +MAFA MAFA DNA-binding; Oncoprotein; Transcription factor; Tumor suppressor Q8NHW3 389692 8q24.3 human S65-p 5403102 PCSSVPSsPSFCAPS activity, induced; protein degradation cell differentiation, altered; transcription, induced 11416124; 35406570 9 0 0 activation of crystallin and NQO1 expression +Stxbp1 STXBP1 Vesicle P61765 25558 3p11 rat T574-p 454395 IGSTHILtPQKLLDT Sec1 molecular association, regulation STX1A(DISRUPTS) 15489225 3 0 0 +H2az1 H2AZ DNA-binding P0C0S6 51788 3|3 G3 mouse K121-ub 486331 HKSLIGKkGQQKTV_ Histone_H2A_C protein degradation 16687393 1 8 86 +ERG ERG DNA-binding; Oncoprotein; Transcription factor P11308 2078 21q22.2 human S96-p 4712353 KGGKMVGsPDTVGMN molecular association, regulation carcinogenesis, induced; cell motility, induced; transcription, induced PRRC2C iso2(DISRUPTS) 28887309; 33554122 4 5 0 +HINT1 HINT1 Cytoskeletal; EC 3.-.-.-; Hydrolase P49773 3094 5q23.3 human Y109-p 457442 SDGGQSVyHVHLHVL HIT cell growth, induced; transcription, induced 28394346 1 1 10 +F3 F3 Cell surface; Membrane protein, integral P13726 2152 1p21.3 human S290-p 451613 GQSWKENsPLNVS__ molecular association, regulation; ubiquitination; intracellular localization; protein conformation; phosphorylation cell motility, altered; cell growth, altered FLNA(INDUCES) 15630487; 18297283; 20076769; 21310953; 27599717; 29044292 11 1 0 promotes angiogenesis +Arhgef15 ephexin-5 GEF; GEF, Rac/Rho Q5FWH6 442801 11|11 B3 mouse S109-p 17546059 PVSRRSIsPEPAPCS activity, induced cytoskeletal reorganization 30485813 1 2 0 Suppression of hippocampal dendritic spine formation; RhoA activation +TPX2 TPX2 Cell cycle regulation; Microtubule-binding Q9ULW0 22974 20q11.21 human T72-p 460008 NLQQAIVtPLKPVDN intracellular localization cell cycle regulation 25688093 2 28 52 important for formation of a bipolar spindle +MAP3K7 TAK1 EC 2.7.11.25; KINASE; Kinase, protein; Protein kinase, Ser/Thr (non-receptor); Protein kinase, TKL O43318 6885 6q15 human T187-p 454704 CDIQTHMtNNKGSAA PK_Tyr_Ser-Thr intracellular localization; phosphorylation; enzymatic activity, induced carcinogenesis, induced; cell growth, induced; signaling pathway regulation; transcription, altered 10838074; 15590691; 17079228; 18299321; 19223549; 19393267; 20538596; 22307082; 31387937; 31511642; 35105963; 36270986 33 1 0 induces TAK1-ADAM17 signaling; induces MAPK-JNK and NFkB signaling pathways; induces MAPK and NF-kB signaling pathways by inducing phosphorylation of JNK and ERK +Foxo1 FOXO1A DNA-binding; Nuclear receptor co-regulator; Oncoprotein; Transcription factor Q9R1E0 56458 3 C|3 23.19 cM mouse S284-p 478910 GQEGPGDsPGSQFSK molecular association, regulation; intracellular localization transcription, inhibited DUSP6(INDUCES) 22503562; 22848439 4 26 1 +GAREM2 FAM59B Unknown function Q75VX8 150946 2p23.3 human Y429-p 28850312 APPAEIPyEELWAHQ molecular association, regulation cell differentiation, induced; signaling pathway regulation GRB2(INDUCES); SHP-2(INDUCES) 24003223 1 0 0 +SMAD2 SMAD2 DNA-binding; Transcription factor Q15796 4087 18q21.1 human S110-p 450144 SFSEQTRsLDGRLQV MH1 molecular association, regulation; intracellular localization SMAD3(INDUCES) 11027280 1 0 0 +LPIN1 LPIN1 EC 3.1.3.4; Phosphatase, lipid Q14693 23175 2p25.1 human Y398-p 1871177710 HLGADGVyLDDLTDM enzymatic activity, induced carcinogenesis, induced; cell growth, induced 33203880 1 1 0 Activity of PAP, increase glycolipid synthesis +CCR5 CCR5 GPCR, family 1; Membrane protein, integral; Membrane protein, multi-pass; Motility/polarity/chemotaxis; Receptor, GPCR; Receptor, cytokine P51681 1234 3p21.31 human S349-p 448724 STGEQEIsVGL____ molecular association, regulation; receptor desensitization, altered; receptor internalization, altered; activity, inhibited ARRB1(INDUCES); ARRB2(INDUCES) 10085131; 11782464; 12065593; 21148810 7 4 0 +LSP1 LSP1 Actin-binding; Motility/polarity/chemotaxis P33241 4046 11p15.5 human S252-p 479435 PKLARQAsIELPSMA Caldesmon intracellular localization 17481585 3 41 175 in chemotaxing neutrophils +MZF1 MZF-1 C2H2-type zinc finger protein; DNA-binding; Transcription factor P28698 7593 19q13.43 human T134-p 27455496 GGPRRWVtVQVQGQE carcinogenesis, altered 31301870 1 1 0 alters cancer cell stemness +PPARA PPAR-alpha DNA-binding; Nuclear receptor; UBIQUITIN LIGASE Q07869 5465 22q13.31 human S12-p 1789802 ESPLCPLsPLEAGDL transcription, inhibited 18079279; 21224484 3 0 0 +ACADVL ACADVL EC 1.3.8.9; Lipid Metabolism - fatty acid; Mitochondrial; Oxidoreductase P49748 37 17p13.1 human K482-sc 33359415 QGCMDKGkELSGLGS molecular association, regulation CRLS1(INDUCES) 25811481 1 1 0 both SIRT3 and SIRT5 KO show reduced afinity for CRLS1 +ITGB3 ITGB3 Cell adhesion; Membrane protein, integral; Motility/polarity/chemotaxis P05106 3690 17q21.32 human S778-p 457413 PLYKEATsTFTNITY Integrin_b_cyt molecular association, regulation; protein conformation; activity, inhibited cell motility, altered; cell adhesion, altered ITGA4(DISRUPTS) 10330414; 18806263 3 0 0 +RHOA RHOA G protein; G protein, monomeric; G protein, monomeric, Rho; Motility/polarity/chemotaxis; Oncoprotein P61586 387 3p21.31 human T100-p 53332704 ENIPEKWtPEVKHFC Ras activity, induced; intracellular localization cytoskeletal reorganization ROCK1(INDUCES) 26816343 1 0 0 enhanced actin stress fiber formation, distributed in the cytoplasm with or without EGF stimulation +MARK1 MARK1 EC 2.7.11.1; EC 2.7.11.26; KINASE; Kinase, protein; Protein kinase, CAMK; Protein kinase, Ser/Thr (non-receptor) Q9P0L2 4139 1q41 human T215-p 456037 TVGNKLDtFCGSPPY Pkinase signaling pathway regulation 24362629 4 45 33 +Myocd myocardin Cell development/differentiation; Transcription factor Q8VIM5 214384 11|11 B3 mouse S636-p 3627511 PQCSPQHsPLGGLKS transcription, inhibited 16141410 1 0 0 +Prkcz PKCZ EC 2.7.11.13; KINASE; Kinase, protein; Protein kinase, AGC; Protein kinase, Ser/Thr (non-receptor) Q02956 18762 4 E2|4 86.17 cM mouse T560-p 447572 TSEPVQLtPDDEDVI Pkinase_C activity, induced; enzymatic activity, induced 15665819; 23354168 13 8 0 +SP1 SP1 C2H2-type zinc finger protein; DNA-binding; Transcription factor P08047 6667 12q13.13 human T453-p 448226 SGPIIIRtPTVGPNG molecular association, regulation carcinogenesis, induced; cell growth, induced; transcription, induced; signaling pathway regulation; transcription, inhibited; transcription, altered NFkB-p65(INDUCES) DNA(INDUCES) 11904305; 14593115; 14744793; 20150555; 32615164 7 0 0 regulates ERK2/Sp1-OSMR pathway +TP53 p53 Activator; DNA-binding; Motility/polarity/chemotaxis; Nuclear receptor co-regulator; Transcription factor; Tumor suppressor P04637 7157 17p13.1 human R249-p 394791401 CMGGMNRrPILTIIT P53 protein stabilization; molecular association, regulation; intracellular localization carcinogenesis, induced; carcinogenesis, altered; cell growth, induced; transcription, induced; signaling pathway regulation Myc(INDUCES); STAT1(INDUCES); PIN1(INDUCES) 29225033; 31747859; 32820905 3 0 0 CDK4/Cyclin D1-c-Myc pathway; rDNA transcription key for ribosomal biogenesis; CDK6-p53RS-PIN1-STAT1 signaling for cell proliferation; inhibits FBW7A ubiquitin ligase activity; PIN1 enhances nuclear localization of phosphorylated R249S mutation, correlated with HBV infection +NFKB2 NFkB-p100 DNA-binding; Oncoprotein; Transcription factor Q00653 4791 10q24.32 human S222-p 3193889 QPIHDSKsPGASNLK molecular association, regulation transcription, altered REL(INDUCES); Bcl-3(DISRUPTS); NFkB-p100(DISRUPTS) 20513428 1 8 0 +Dppa4 DPPA4 Cell development/differentiation Q8CCG4 73693 16|16 B5 mouse K143-sm 1877126902 KTAHKKMkTEPGEES transcription, inhibited 32937131 1 1 0 +RBL1 Rb-like 1 Transcription, coactivator/corepressor; Tumor suppressor P28749 5933 20q11.23 human S964-p 451297 MMDAPPLsPFPHIKQ Rb_C molecular association, regulation cell growth, altered E2F4(DISRUPTS) 11884610; 12006580 2 14 14 +STAT5A STAT5A DNA-binding; Motility/polarity/chemotaxis; Oncoprotein; Transcription factor P42229 6776 17q21.2 human S726-p 448749 TYMDQAPsPAVCPQA intracellular localization carcinogenesis, induced; cell growth, induced; apoptosis, inhibited; transcription, altered 21716071; 34188118; 36342456 19 1 0 +ERF ERF DNA-binding; Transcription factor P50548 2077 19q13.2 human S251-p 456968 PLSPFPVsPLAGPGS intracellular localization cell cycle regulation 10330152; 14729966 2 2 1 +Dgkg DGKG EC 2.7.1.107; Kinase, lipid; Lipid Metabolism - glycerolipid; Lipid Metabolism - glycerophospholipid; Motility/polarity/chemotaxis P49620 25666 11q23 rat S779-p 471078 PQKSSFFsLRRKSRS enzymatic activity, induced 16905533 1 6 1 +OSBP OSBP Lipid-binding P16258 rabbit S381-p 468341 LGHKRTGsNISGASS molecular association, regulation; intracellular localization; phosphorylation VAPA(DISRUPTS) 11441133; 22875984 2 46 1 phosphorylation of downstream serine residues. S381A/S3D double mutant has enhanced binding and altered localization. Regulation of sphingomyelin synthesis. +CTNNB1 CTNNB1 Actin-binding; Cell adhesion; Motility/polarity/chemotaxis; Nuclear receptor co-regulator; Oncoprotein; Transcription factor P35222 1499 3p22.1 human S246-p 469995 ALVKMLGsPVDSVLF Arm protein stabilization; molecular association, regulation; intracellular localization; protein conformation transcription, induced PIN1(INDUCES) 17009320; 26740630 3 0 0 nuclear retention +Hdac2 HDAC2 DEACETYLASE; Deacetylase; EC 3.5.1.98; Nuclear receptor co-regulator; Transcription, coactivator/corepressor P70288 15182 10 19.44 cM|10 B1 mouse S424-p 467980 CDEEFSDsEDEGEGG enzymatic activity, induced 21576649 4 73 49 +MECOM EVI1 C2H2-type zinc finger protein; Methyltransferase, protein lysine, predicted; Oncoprotein; Transcription regulation; Transcription, coactivator/corepressor Q03112 2122 3q26.2 human S1037-p 482637 IGNSNHGsQSPRNVE molecular association, regulation cell motility, induced; cell growth, induced; transcription, induced DNA(INDUCES) 23858473 1 6 0 +RAF1 RAF1 EC 2.7.11.1; KINASE; Kinase, protein; Oncoprotein; Protein kinase, Ser/Thr (non-receptor); Protein kinase, TKL P04049 5894 3p25.2 human S619-p 5822317 SLPKINRsASEPSLH enzymatic activity, induced 8288587 1 5 1 +YAP1 YAP1 Oncoprotein; Transcription, coactivator/corepressor P46937 10413 11q22.1 human S289-p 3190663 PPPLAPQsPQGGVMG molecular association, regulation cell cycle regulation; carcinogenesis, induced; cell motility, induced; apoptosis, inhibited; cytoskeletal reorganization TEAD4(DISRUPTS) 24101154; 24812269 4 24 1 +PTTG1 Securin Cell cycle regulation; Oncoprotein O95997 9232 5q33.3 human S171-p 5829579 PSPVKMPsPPWESNL Securin protein stabilization; molecular association, regulation; phosphorylation carcinogenesis, altered; transcription, induced; signaling pathway regulation CTNNB1(INDUCES) 37400529 1 0 1 induces GSK3B dephosphorylation, regulates Wnt/?-catenin signaling +LEO1 LEO1 Transcription regulation Q8WVC0 123169 15q21.2 human S91-p 1271628700 SDNRSEAsERSDHED molecular association, regulation; intracellular localization carcinogenesis, inhibited; cell growth, inhibited; apoptosis, induced; transcription, inhibited; signaling pathway regulation CTNNB1(DISRUPTS) 30305722 1 1 0 +ARHGAP24 ARHGAP24 GAP; GAP, Rac/Rho; Motility/polarity/chemotaxis Q8N264 83478 4q21.23-q21.3 human S413-p 12518707 SVHKLDVsRSPPLMV activity, induced cytoskeletal reorganization 16862148 1 4 0 membrane blebbing +Kcnk2 TREK-1 Channel, potassium; Membrane protein, integral; Membrane protein, multi-pass P97438 16526 1|1 H6 mouse S366-p 457099 TSVKRKLsAELAGNH activity, induced 11560940 1 2 2 increases open probability of the (K+) channel +AMOT AMOT Q4VCS5 154796 Xq23 human S175-p 28699604 QGHVRSLsERLMQMS protein stabilization; molecular association, regulation; ubiquitination; intracellular localization cell growth, inhibited; cytoskeletal reorganization; cell motility, inhibited; transcription, inhibited; signaling pathway regulation ACTA1(DISRUPTS); ACTB(DISRUPTS); 14-3-3 gamma(INDUCES); YAP1(INDUCES); ITCH(INDUCES); Merlin(INDUCES) 24101513; 24106267; 24225952; 28464980; 29317530 8 0 0 S175A mutant nuclear localization, S175E cytoplasm and cell membrane localization, localization of complex +Smad4 SMAD4 DNA-binding; Nuclear receptor co-regulator; Transcription, coactivator/corepressor P97471 17128 18 E2|18 49.51 cM mouse T276-p 449628 GSRTAPYtPNLPHHQ intracellular localization transcription, induced 12801888 3 0 0 +LSM4 LSM4 RNA-binding; Spliceosome Q9Y4Z0 25804 19p13.11 human R109-m2 15381284 RGMGGAGrGVFGGRG molecular association, regulation SMN(INDUCES) 11720283 1 1 3 +Mlxipl ChREBP Transcription factor Q8VIP2 171078 12q12 rat S196-p 451393 KKRLRKSsREGDFLA molecular association, regulation; intracellular localization; activity, inhibited transcription, altered 14-3-3 beta(INDUCES); KPNA1(INDUCES); KPNA2(DISRUPTS) 11698644; 18606808; 21665952 5 8 1 inhibits nuclear localization of ChREBP under low glucose conditions +Ptpre PTPRE EC 3.1.3.48; Membrane protein, integral; Motility/polarity/chemotaxis; PHOSPHATASE; Receptor protein phosphatase, tyrosine P49446 19267 7 F3|7 81.27 cM mouse Y695-p 450705 FIDIFSDyANFK___ molecular association, regulation; enzymatic activity, induced cell growth, altered GRB2(INDUCES); TUBA4A(INDUCES); PTPRE(DISRUPTS) 10490839; 17486066; 17709387 4 22 597 Binding to tubulin decreases the cyt-PTPRE phosphatase activity.; reduced dimerization of glycosylated PTPRE mediated by HER2; essential for activation of Src by dephosphorylation +Atat1 ATAT1 iso2 ACETYLTRANSFERASE; Acetyltransferase; EC 2.3.1.108 Q8K341-2 73242 17|17 B1 mouse K146-ac 27581501 LFQHMLQkERVEPHQ Acetyltransf_16 enzymatic activity, induced 23275437 1 1 0 +MSX1 MSX1 DNA-binding; Motility/polarity/chemotaxis P28360 4487 4p16.2 human K133-sm 12004421 LPEDALVkAESPEKP cell differentiation, inhibited; transcription, inhibited 16600910 2 0 0 PIAS1 binding to MSX1 is required for inhibiting cell differentiation and transcriptional repression, but sumoylation is not required +CRYAA CRYA1 Chaperone; Heat shock protein P02489 1409 21q22.3 human K70-ac 459001 EVRSDRDkFVIFLDV HSP20 activity, induced; molecular association, regulation; protein conformation apoptosis, inhibited 22120592; 23508955 2 4 0 +UNG UNG EC 3.2.2.27; Hydrolase P13051 7374 12q24.11 human T6-p 453426 __MIGQKtLYSFFSP molecular association, regulation PCNA(DISRUPTS) 28746850 1 1 0 +Nefl NFL Cytoskeletal P19527 83613 15p12 rat S56-p 451024 SSLSVRRsYSSSSGS Filament_head cytoskeletal reorganization 22705628 9 3 1 +Rela NFkB-p65 DNA-binding; Nuclear receptor co-regulator; Transcription factor Q04207 19697 19 A|19 4.34 cM mouse S311-p 449966 RTYETFKsIMKKSPF molecular association, regulation apoptosis, inhibited; transcription, induced p300(INDUCES) 12881425 17 2 1 +Egfr EGFR EC 2.7.10.1; KINASE; Kinase, protein; Membrane protein, integral; Oncoprotein; Protein kinase, TK; Protein kinase, tyrosine (receptor) Q01279 13649 11 A2|11 9.41 cM mouse Y1069-p 448056 EDAFLQRySSDPTGA protein degradation; molecular association, regulation; phosphorylation cell motility, altered; apoptosis, inhibited CBL(INDUCES) 10635327; 16123117; 17139251 45 18 117 promotes phosphorylation of Cbl +PCBP2 hnRNP E2 RNA splicing; RNA-binding Q15366 5094 12q13.13 human S189-p 482917 YRPKPSSsPVIFAGG protein stabilization; molecular association, regulation cell differentiation, inhibited; translation, inhibited RNA(INDUCES) 17475908 2 56 11 +Cacna1d CACNA1D Channel, calcium; Membrane protein, integral; Membrane protein, multi-pass P27732 29716 16p16 rat S1816-p 6062701 AAHGKRPsIGDLEHV CAC1F_C activity, induced 19074150 1 0 0 +Gabrg2 GABRG2 Channel, chloride; Channel, ligand-gated; Membrane protein, integral; Membrane protein, multi-pass; Transporter; Transporter, ion channel P22723 14406 11 A5|11 24.8 cM mouse S365-p 486436 FVSNRKPsKDKDKKK Neur_chan_memb receptor desensitization, altered 17875639 9 0 0 +NCOA3 SRC-3 ACETYLTRANSFERASE; Acetyltransferase; EC 2.3.1.48; Motility/polarity/chemotaxis; Nuclear receptor co-regulator; Transcription, coactivator/corepressor Q9Y6Q9 8202 20q13.12 human S1330-p 3217872 PAFGRVSsPPNAMMS DUF1518 molecular association, regulation carcinogenesis, inhibited; cell growth, inhibited; transcription, inhibited; signaling pathway regulation ATF-4(DISRUPTS) DNA(DISRUPTS) 31066068 2 14 0 Dyrk3/NCOA3/ATF4 signaling pathway +Rb1 Rb Nuclear receptor co-regulator; Oncoprotein; Transcription, coactivator/corepressor; Tumor suppressor P13405 19645 14 38.73 cM|14 D3 mouse S561-p 450021 SLAWLSDsPLFDLIK RB_A molecular association, regulation E2F1(DISRUPTS) 10207050 6 0 0 +SIRT1 SIRT1 Apoptosis; DEACETYLASE; Deacetylase; EC 3.5.1.-; Nuclear receptor co-regulator Q96EB6 23411 10q21.3 human K734-sm 1968605 INEAISVkQEVTDMN acetylation; enzymatic activity, induced apoptosis, inhibited; transcription, inhibited 17934453 2 1 0 induces deacetylation of p53 +Adra2a ADRA2A GPCR, family 1; Membrane protein, integral; Membrane protein, multi-pass; Receptor, GPCR P22909 25083 1q55 rat T388-p 467298 QNREKRFtFVLAVVI 7tm_1; TM activity, inhibited 15118347 1 0 0 +HSPA8 HSC70 Chaperone; Heat shock protein; Nucleolus; RNA-binding P11142 3312 11q24.1 human K561-m3 3898513 EDEKLQGkINDEDKQ HSP70 molecular association, regulation SNCA(DISRUPTS) 23921388 3 5 5 +ACSL4 ACSL4 EC 6.2.1.3; Ligase; Lipid Metabolism - fatty acid; Membrane protein, integral O60488 2182 Xq23 human K388-ub 21128158 IYKNVMSkVQEMNYI AMP-binding protein degradation 37428466 1 4 0 inhibition of ACSL4-driven lipid peroxidation and ferroptosis is necessary for CDK1 to promote oxaliplatin resistance in CRC +Rtn4 Nogo iso2 Cell development/differentiation; Endoplasmic reticulum; Inhibitor; Membrane protein, integral; Membrane protein, multi-pass; Motility/polarity/chemotaxis Q9JK11-2 rat S16-p 468313 LVSSSTDsPPRPPPA protein degradation apoptosis, altered 18072206 1 51 1 Phosphorylation regulates clevage of Nogo B. +RPS6KB1 p70S6K iso2 EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, AGC; Protein kinase, Ser/Thr (non-receptor); Translation P23443-2 6198 17q23.1 human T389-p 448607 NQVFLGFtYVAPSVL Pkinase_C phosphorylation; enzymatic activity, induced carcinogenesis, induced 18326039; 25936802; 37078777 476 9 1 reduces sensitivity to sunitinib; induces S6 phosphorylation +BRAF BRAF EC 2.7.11.1; KINASE; Kinase, protein; Oncoprotein; Protein kinase, Ser/Thr (non-receptor); Protein kinase, TKL P15056 673 7q34 human T599-p 447807 IGDFGLAtVKSRWSG PK_Tyr_Ser-Thr molecular association, regulation; protein conformation; enzymatic activity, induced carcinogenesis, induced; cell differentiation, altered; cell growth, induced; transcription, induced; transcription, altered; cell growth, altered BRAF(NOT_REPORTED) 11032810; 11293329; 15035987; 15710605; 18451171; 23907581; 26657898 12 0 0 phosphorylation at T599 and S602 and K578 ubiquitination mediate ERK activation +Nphs1 NPHS1 Cell adhesion; Immunoglobulin superfamily; Membrane protein, integral Q9QZS7 54631 7|7 B1 mouse Y1208-p 469565 PGVWGPLyDEVQMDP molecular association, regulation cytoskeletal reorganization NCK1(INDUCES) 18212058; 34391780 16 1 0 induce podocyte repair +NFE2L2 NRF2 DNA-binding; Transcription factor Q16236 4780 2q31.2 human K533-ac 7106322 EQDLDHLkDEKEKLL bZIP_Maf molecular association, regulation transcription, induced DNA(INDUCES) 19273602 1 1 0 +Canx Calnexin Calcium-binding; Endoplasmic reticulum; Membrane protein, integral; Motility/polarity/chemotaxis P35565 29144 10q22 rat S563-p 456360 EEDGGTGsQDEEDSK molecular association, regulation; activity, inhibited SERCA2(INDUCES) 10851021 7 85 48 inhibition of cytosolic Ca2+ waves +Npr1 ANPA EC 4.6.1.2; Guanylyl cyclase; KINASE; Kinase, protein; Lyase; Membrane protein, integral; Nucleotide Metabolism - purine; Protein kinase, RGC; Protein kinase, dual-specificity (receptor); Receptor, misc. P18910 24603 2q34 rat S501-p 25528503 QLEKELVsELWRVRW receptor desensitization, induced; enzymatic activity, induced 22590601 2 0 0 +NDUFA12 NDUFA12 EC 1.6.5.3; EC 1.6.99.3; Mitochondrial; Oxidoreductase Q9UI09 55967 12q22 human T142-p 33402204 QEWIPPStPYK____ activity, induced cell cycle regulation 24746669 1 1 0 increases mitochondrial respiration for G/2M transition +YWHAB 14-3-3 beta Adaptor/scaffold P31946 7529 20q13.12 human K51-ac 474927 NLLSVAYkNVVGARR 14-3-3 molecular association, regulation; intracellular localization; activity, inhibited cell differentiation, induced SYNPO(DISRUPTS) 23840712; 34379822 2 5 15 osteogenesis +RANBP2 RANBP2 Adaptor/scaffold; EC 5.2.1.8; EC 6.3.2.-; Ligase; Nuclear export; Nucleoporin; SUMO LIGASE; SUMO conjugating system; SUMO ligase P49792 5903 2q13 human S2251-p 468569 HASPLASsPVRKNLF molecular association, regulation; intracellular localization BICD2(INDUCES) 26051540 2 29 0 targets BicD2 to the NE of RGP cells to induce apical nuclear migration +SRPK2 SRPK2 EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, CMGC; Protein kinase, Ser/Thr (non-receptor) P78362 6733 7q22.3 human S494-p 483631 HDRSRTVsASSTGDL intracellular localization transcription, induced 29153836 1 54 18 transcription of genes involved in de novo lipid synthesis; nuclear translocation +Dlg1 DLG1 Adaptor/scaffold; Motility/polarity/chemotaxis Q62696 25252 11q22 rat S431-p 4749386 QSVDNHVsPSSYLGQ PDZ_assoc molecular association, regulation; intracellular localization cytoskeletal reorganization GKAP1(DISRUPTS) 15729360 1 0 1 +ADRA1D ADRA1D GPCR, family 1; Membrane protein, integral; Membrane protein, multi-pass; Receptor, GPCR P25100 146 20p13 human S518-p 1346843000 RAKVSSLsHKIRAGG receptor internalization, induced; molecular association, regulation; intracellular localization; receptor internalization, altered signaling pathway regulation ARRB1(INDUCES) 29551601; 30419287 2 1 0 triggers the calcium signaling pathway; regulates ERK signaling pathway, induces calcium signaling de-sensitization +Kras KRas G protein; G protein, monomeric; G protein, monomeric, Ras; Motility/polarity/chemotaxis; Oncoprotein P32883 16653 6 G3|6 77.37 cM mouse K147-ac 56423802 PFIETSAkTRQRVED Ras enzymatic activity, altered carcinogenesis, induced; cell growth, induced; signaling pathway regulation 27637077 2 2 0 regulates KRas-downstream oncogenic pathway-Raf/MEK/ERK pathway +PALLD palladin Cytoskeletal; Motility/polarity/chemotaxis Q8WX93 23022 4q32.3 human S1118-p 468361 VRRPRSRsRDSGDEN cell motility, altered; cytoskeletal reorganization 20471940 1 40 71 +Gabrg2 GABRG2 Channel, chloride; Channel, ligand-gated; Membrane protein, integral; Membrane protein, multi-pass; Transporter; Transporter, ion channel Q6PW52 29709 10q21 rat S365-p 486436 FVSNRKPsKDKDKKK Neur_chan_memb receptor internalization, induced; intracellular localization endocytosis, induced 20823221; 34657931; 34936876 9 0 0 +Tp53 p53 Activator; DNA-binding; Motility/polarity/chemotaxis; Nuclear receptor co-regulator; Transcription factor; Tumor suppressor P02340 22059 11 B3|11 42.83 cM mouse K379-ac 458977 QSTSRHKkTMVKKVG activity, induced; protein stabilization apoptosis, induced; transcription, induced; transcription, inhibited 10990460; 12356735; 17581637; 25758227; 33323382 216 10 0 P53K Q/- mice died prematurely due to anemia, loss of hematopoiesis stem cells, Loss of stem cells in the testis, activation in p53 KQ/- mice without robust p53 stabilization,p53-KQ/- mutant leads to effective suppression of tumor development in a pancreatic ductal adenocarcinoma mouse model, mutant proteins extended the life-span of a PDAC mouse model +MEFV pyrin Actin-binding O15553 4210 16p13.3 human S208-p 455897 VRLRRNAsSAGRLQG molecular association, regulation; intracellular localization; activity, inhibited 14-3-3 theta(INDUCES); 14-3-3 epsilon(INDUCES) 15934090; 27270401; 36223753 8 1 2 +MAP3K2 MEKK2 EC 2.7.11.25; KINASE; Kinase, protein; Protein kinase, STE; Protein kinase, Ser/Thr (non-receptor) Q9Y2U5 10746 2q14.3 human T524-p 1904501 GMKSVTGtPYWMSPE Pkinase phosphorylation; enzymatic activity, induced transcription, altered 16362041 1 1 0 Mutation of S520A inhibits activation and is the key residue. Double mutation of T522A,T524A reduces activation effect. T522A seems to have the least effect of the three single mutations. The triple STT to AAA mutation is akin to kinase dead. Activation leads to Erk5 and JNKK2 phosphorylation/activation. +PARP1 PARP1 DNA repair, damage; EC 2.4.2.30; Nuclear envelope; Nuclear receptor co-regulator; Nucleolus; Transferase P09874 142 1q42.12 human K221-ub 21180920 DGVDEVAkKKSKKEK cell motility, induced; cell growth, induced; apoptosis, inhibited; DNA repair, inhibited; signaling pathway regulation 36088509 1 1 0 HECTD3 activates the EGFR-mediated signalling pathway through PARP1. +SHCBP1 SHCBP1 Adaptor/scaffold Q8NEM2 79801 16q11.2 human S273-p 3206802 SSLSNCNsDSEQENI intracellular localization cell cycle regulation; carcinogenesis, induced; cell motility, induced; cell growth, induced 33990570; 35013128 2 7 1 +STAT2 STAT2 DNA-binding; Transcription factor P52630 6773 12q13.3 human T387-p 60152500 TSNQKTLtPEKGQSQ STAT_bind activity, inhibited cell growth, induced; transcription, inhibited 27852626 1 1 0 +ZNF322 ZNF322A C2H2-type zinc finger protein; Transcription factor Q6U7Q0 79692 6p22.2 human T234-p 1246856 IVHKRVHtGEKPYKC activity, induced; molecular association, regulation carcinogenesis, induced; chromatin organization, altered; cell motility, induced; cell growth, induced; transcription, induced DNA(INDUCES) 31399647 1 5 5 chromatin binding; increases recruitment to ADD1 and CCND1 promoters +TRPM4 TRPM4 Membrane protein, integral; Membrane protein, multi-pass Q8TD43 54795 19q13.33 human S1145-p 12559511 RDKRESDsERLKRTS activity, induced 15590641 1 0 0 +ACBD5 ACBD5 iso2 Lipid-binding; Membrane protein, integral Q5T8D3-2 91452 10p12.1 human T258-p 1876128606 VTGIQHLtSDSDSEV molecular association, regulation VAPB(INDUCES) 35019937 1 1 0 +SRSF1 SF2 RNA splicing; RNA-binding; Spliceosome Q07955 6426 17q22 human R97-m1 1308911 RSGRGTGrGGGGGGG intracellular localization RNA splicing, induced; RNA stability, inhibited; translation, induced 20308322 1 8 49 prevents SF2 nuclear import and splicing of target genes, and translation is increased in the cytoplasm +BDNF BDNF Cell development/differentiation; Cytokine; Secreted; Secreted, signal peptide P23560 627 11p14.1 human T62-p 30259809 GLTSLADtFEHVIEE cell differentiation, induced; transcription, induced 23712400 1 0 0 increases OPN and BMP2 mRNA expression +PDHA1 PDHA1 Amino Acid Metabolism - valine, leucine and isoleucine biosynthesis; Carbohydrate Metabolism - butanoate; Carbohydrate Metabolism - citrate (TCA) cycle; Carbohydrate Metabolism - glycolysis and gluconeogenesis; Carbohydrate Metabolism - pyruvate; EC 1.2.4.1; Mitochondrial; Oxidoreductase P08559 5160 Xp22.12 human Y301-p 454753 MSDPGVSyRTREEIQ E1_dh molecular association, regulation carcinogenesis, induced; cell growth, induced Other(DISRUPTS) 25104357 2 36 1386 inhibits pyruvate binding +Hdgf HDGF Cytokine; Transcription regulation P51859 15191 3 F1|3 38.78 cM mouse S165-p 452720 AGDVLEDsPKRPKES protein processing; intracellular localization 21087088 2 117 29 positively regulates HDGF secretion by inhibiting its N-terminal truncation +Smad3 SMAD3 DNA-binding; Nuclear receptor co-regulator; Transcription factor Q8BUN5 17127 9|9 C mouse S204-p 451178 NHSMDAGsPNLSPNP protein stabilization; molecular association, regulation; enzymatic activity, induced apoptosis, induced; transcription, induced; signaling pathway regulation 29700281 17 0 0 increase MELK stability and activity; regulate ASK1/TGF-beta/p53 signaling pathways +Tnp2 TP2 DNA-binding P11101 24840 10q11 rat T101-p 450901 AVRRRKRtHRAKRRS TP2 intracellular localization 14514679 1 0 0 +LIPE HSL EC 3.1.1.79; Lipase Q05469 3991 19q13.2 human S950-p 450194 EGFHPRRsSQGATQM Abhydrolase_3 molecular association, regulation; enzymatic activity, induced FABP4(INDUCES) 17785468; 19018281 8 5 4 +Syn1 SYN1 Vesicle O88935 20964 X A1.3|X 16.37 cM mouse S605-p 450236 AGPTRQAsQAGPGPR neural plasticity; signaling pathway regulation 31242289; 36207442 21 10 11 +Junb JunB Motility/polarity/chemotaxis; Oncoprotein; Transcription factor P24898 24517 19q11 rat S186-p 1814003 YTNLSSYsPASAPSG Jun protein degradation cell cycle regulation; transcription, altered 10790372 1 0 0 Phosphorylation promoted degradation during the G2-M transition. JunB inhibition of cyclin D1 transcription is relieved by JunB protein degradation. +Cd83 CD83 Membrane protein, integral O88324 12522 13 A4|13 21.6 cM mouse K168-ub 9381801 SIFPDISkPGTEQAF protein degradation 19542455 1 0 0 +PPP1R2 PPP1R2 Inhibitor; Motility/polarity/chemotaxis; Protein phosphatase, regulatory subunit P41236 5504 3q29 human T73-p 449051 MKIDEPStPYHSMMG IPP-2 intracellular localization; protein conformation; enzymatic activity, induced cell cycle regulation PPP1R2(INDUCES) 18062707; 22982244; 9405437 11 4 0 +H1-4 H1E DNA-binding P10412 3008 6p22.2 human K26-ac 9926962 PVKKKARkSAGAAKR cell cycle regulation 24873882 1 0 1 +PARD3 PAR3-alpha Adaptor/scaffold; Motility/polarity/chemotaxis Q8TEW0 56288 10p11.22-p11.21 human S144-p 455668 PLHVRRSsDPALIGL molecular association, regulation cytoskeletal reorganization GAB1(DISRUPTS); 14-3-3 zeta(INDUCES) 14653998; 22883624 4 21 26 +TSC2 TSC2 Cell cycle regulation; GAP; GAP, misc.; Nuclear receptor co-regulator; Tumor suppressor P49815 7249 16p13.3 human S1254-p 448807 TALYKSLsVPAASTA molecular association, regulation 14-3-3 beta(INDUCES) 12582162 6 23 14 +Pkmyt1 Myt1 EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, Other; Protein kinase, Ser/Thr (non-receptor); Protein kinase, dual-specificity (non-receptor) Q95YJ1 starfish S75-p 449752 ESRPRAVsFRQSEPS activity, inhibited cell cycle regulation 11802161 1 0 0 +YAP1 YAP1 iso2 Oncoprotein; Transcription, coactivator/corepressor P46937-2 10413 11q22.1 human S164-p 471933 AQHLRQSsFEIPDDV activity, inhibited cell differentiation, induced; cell growth, inhibited; transcription, inhibited 23027127; 23752589 13 16 45 +MYC Myc DNA-binding; Nucleolus; Oncoprotein; Transcription factor P01106 4609 8q24.21 human S359-p 25173074 SNNRKCTsPRSSDTE Myc_N carcinogenesis, inhibited; transcription, inhibited 24030976 2 7 0 +SENP3 SENP3 DESUMOYLASE; EC 3.4.22.68; Nucleolus; Protease; Sumo-specific protease Q9H4L4 26168 17p13.1 human T142-p 36438200 MLLYSKStSLTFHWK molecular association, regulation; intracellular localization NPM1(INDUCES) 25288641 1 1 0 ribosome biogenesis-28S rRNA maturation +Itgb2 ITGB2 Cell adhesion; Cell surface; Membrane protein, integral; Motility/polarity/chemotaxis; Receptor, misc. P11835 16414 10 C1|10 39.72 cM mouse T762-p 450185 LFKSATTtVMNPKFA Integrin_b_cyt cell motility, induced; cell adhesion, induced 23823319 3 0 0 T-cell homing to lymphocytes +Stmn2 STMN2 Cytoskeletal P21818 84510 2q23 rat S50-p 455606 KQINKRAsGQAFELI Stathmin molecular association, regulation cytoskeletal reorganization TUBA1A(INDUCES); TUBB(INDUCES) 15825189; 9525956 5 5 0 +Lat2 LAB Adaptor/scaffold; Membrane protein, integral Q9JHL0 56743 5|5 G2 mouse Y160-p 450645 GVEDFEDyQNSVSIH LAT2 signaling pathway regulation 22308309 3 8 151 plays a negative role in TCR and FcRI-mediated and no role in LPS-mediated signaling +Bad BAD Apoptosis Q61337 12015 19|19 A mouse S136-p 447862 PFRGRSRsAPPNLWA Bcl-2_BAD activity, induced; molecular association, regulation; intracellular localization; activity, inhibited; phosphorylation apoptosis, altered; apoptosis, inhibited; cell growth, altered Bcl-xL(NOT_REPORTED); JNK1(DISRUPTS); 14-3-3 zeta(INDUCES); PKACA(INDUCES); 14-3-3 beta(NOT_REPORTED); PPP2CA(INDUCES); 14-3-3 beta(INDUCES); 14-3-3 theta(INDUCES); Bcl-2(DISRUPTS); PKCA(INDUCES); Bcl-xL(DISRUPTS) 10611223; 10777478; 10887134; 10949026; 10996800; 11526496; 11723239; 12754297; 12897128; 12944463; 14670836; 15123689; 16009721; 16103085; 16403219; 19217411; 20813501; 22103330; 23332762; 34023385; 8929531; 9346240; 9651683 124 55 216 +Ntrk2 TrkB EC 2.7.10.1; KINASE; Kinase, protein; Membrane protein, integral; Protein kinase, TK; Protein kinase, tyrosine (receptor) Q63604 25054 17p14 rat Y515-p 448813 PVIENPQyFGITNSQ molecular association, regulation; phosphorylation; enzymatic activity, induced translation, altered; signaling pathway regulation SHC3(INDUCES); SHC1(INDUCES); SHC2(INDUCES) 10196222; 10533983; 12006576; 15362724; 16223723; 16573649; 22563458 23 2 40 c-fos protein synthesis induced by BDNF; activation of PLC-gamma1 and MAPK/PI3K signal transduction pathways; Y515F attenuates phosphorylation levels of FRS2, TrkB autophosphorylation levels, and ERK activation after BDNF treatment. +PGK1 PGK1 Carbohydrate Metabolism - glycolysis and gluconeogenesis; EC 2.7.2.3; KINASE; Kinase, other P00558 5230 Xq21.1 human K323-ac 479484 CGPESSKkYAEAVTR PGK enzymatic activity, induced carcinogenesis, induced; cell growth, induced 27774669 2 5 22 +Rps5 RPS5 RNA-binding; Ribosomal; Translation P97461 20103 7|7 A1 mouse S24-p 9819906 IKLFGKWsTDDVQIN intracellular localization 19631221 1 0 0 +TSPY1 TSPY1 Cancer Testis Antigen (CTA) Q01534 7258 Yp11.2 human T300-p 460704 PPEEGTEtSGDSQLL protein stabilization; intracellular localization 16426576 1 0 0 important for the nuclear transport +WNK4 WNK4 EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, Other; Protein kinase, Ser/Thr (non-receptor) Q96J92 65266 17q21.2 human Y1115-p 40407607 PVWMNYSySSLCLSS activity, inhibited 25805816 1 1 0 WNK4 inhibition of ROMK channels +Tec TEC EC 2.7.10.2; KINASE; Kinase, protein; Protein kinase, TK; Protein kinase, tyrosine (non-receptor) P24604 21682 5 C3.2|5 38.44 cM mouse Y518-p 447891 RYVLDDQyTSSSGAK PK_Tyr_Ser-Thr molecular association, regulation; enzymatic activity, induced DOK1(INDUCES) 20697350 1 20 322 +CACNA1C CACNA1C iso12 Channel, calcium; Membrane protein, integral; Membrane protein, multi-pass Q13936-12 775 12p13.33 human Y2134-p 1043301 ELQDSRVyVSSL___ signaling pathway regulation 20128810 2 0 0 mutation (Y to F) prevents depolarization-induced CRE activation +STAT2 STAT2 DNA-binding; Transcription factor P52630 6773 12q13.3 human Y631-p 479848 LIYSVQPyTKEVLQS SH2 apoptosis, inhibited 17442890 1 0 0 STAT2 Y631F mutant promotes IFN-alpha-induced apoptosis +HIF1A HIF1A Autophagy; DNA-binding; Transcription factor Q16665 3091 14q23.2 human S576-p 17331801 DDDFQLRsFDQLSPL HIF-1 protein degradation 20889502 1 1 0 +FOXM1 FOXM1 DNA-binding; Transcription factor Q08050 2305 12p13.33 human K478-sm 31898503 PHLARPIkVESPPLE protein degradation; ubiquitination; intracellular localization cell cycle regulation; cell growth, inhibited; transcription, inhibited 24362530 2 0 0 +GATA1 GATA1 DNA-binding; Transcription factor P15976 2623 Xp11.23 human S310-p 451231 QTRNRKAsGKGKKKR molecular association, regulation cell growth, induced; cell differentiation, induced; transcription, induced; transcription, inhibited FOG1(INDUCES) 16107690; 26680303; 35580337 10 0 0 +IRF1 IRF1 Transcription factor; Tumor suppressor P10914 3659 5q31.1 human K95-ub 31914113 LPDIEEVkDQSRNKG IRF protein degradation; molecular association, regulation DNA(DISRUPTS) 23134341 1 2 0 +MYB Myb DNA-binding; Oncoprotein; Transcription factor P10242 4602 6q23.3 human K485-ac 458943 EIKYGPLkMLPQTPS Cmyb_C molecular association, regulation transcription, induced DNA(INDUCES) 10656693 1 0 0 +MAP2K1 MEK1 EC 2.7.12.2; KINASE; Kinase, protein; Protein kinase, STE; Protein kinase, dual-specificity (non-receptor) Q02750 5604 15q22.31 human T386-p 448288 IGLNQPStPTHAAGV molecular association, regulation; intracellular localization ERK2(INDUCES) 10567369; 18760948 5 6 57 nuclear translocation +Irs2 IRS2 Adaptor/scaffold; Motility/polarity/chemotaxis P81122 384783 8 A1.1|8 5.35 cM mouse Y814-p 454963 CSGDNDQyVLMSSPV molecular association, regulation; phosphorylation signaling pathway regulation PIK3R1(INDUCES) 24811175 1 29 692 promotes GSK3B phosphorylation, regulates aerobic glycolysis +YY1 YY1 C2H2-type zinc finger protein; Cell development/differentiation; Transcription factor P25490 7528 14q32.2 human Y254-p 464367 SPPDYSEyMTGKKLP transcription, inhibited 29807053 2 1 1 +Ctnnb1 CTNNB1 Actin-binding; Cell adhesion; Motility/polarity/chemotaxis; Nuclear receptor co-regulator; Oncoprotein; Transcription factor Q02248 12387 9 F4|9 72.19 cM mouse T120-p 6406005 QFDAAHPtNVQRLAE intracellular localization transcription, inhibited; signaling pathway regulation 31662443 6 0 0 GSK3B/B-Catenin/TCF-21 pathway +STK38L NDR2 EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, AGC; Protein kinase, Ser/Thr (non-receptor) Q9Y2H1 23012 12p11.23 human S282-p 460298 NRRQLAYsTVGTPDY Pkinase molecular association, regulation; enzymatic activity, induced cell growth, altered MST1(INDUCES); MOB1A(INDUCES); CCND1(INDUCES) 15037617; 16314523; 16488889; 23897809 4 1 10 +GLI1 GLI1 C2H2-type zinc finger protein; Oncoprotein; Transcription factor P08151 2735 12q13.3 human K518-ac 31077501 PIGTRGLkLPSLSHT transcription, inhibited 28716052 2 0 0 +Kirrel1 KIRREL Cell adhesion; Membrane protein, integral Q80W68 170643 3|3 F1 mouse Y637-p 463751 MKDPTNGyYNVRAHE molecular association, regulation cytoskeletal reorganization GRB2(INDUCES) 17923684; 34391780 3 12 84 induce podocyte repair +CCKBR CCKBR GPCR, family 1; Membrane protein, integral; Membrane protein, multi-pass; Receptor, GPCR P32239 887 11p15.4 human S434-p 6057803 TPSIASLsRLSYTTI molecular association, regulation RGS2(INDUCES) 19064631 1 1 0 +Phb1 PHB Apoptosis; Cell cycle regulation; Chaperone; Mitochondrial; Motility/polarity/chemotaxis; Nuclear receptor co-regulator; Oncoprotein; Transcription, coactivator/corepressor P67778 18673 11 59.01 cM|11 D mouse T258-p 11139253 LSRSRNItYLPAGQS molecular association, regulation carcinogenesis, induced; cell motility, induced RAF1(INDUCES) 22388104; 32859869 6 0 1 +EGFR EGFR EC 2.7.10.1; KINASE; Kinase, protein; Membrane protein, integral; Oncoprotein; Protein kinase, TK; Protein kinase, tyrosine (receptor) P00533 1956 7p11.2 human K1061-ub 27187816 GLQSCPIkEDSFLQR protein stabilization 32669362 1 4 0 SMURF2-UBE2D1 protein?protein interaction affects mutant EGFR levels +Ptk2 FAK EC 2.7.10.2; KINASE; Kinase, protein; Protein kinase, TK; Protein kinase, tyrosine (non-receptor) P34152 14083 15 D3|15 33.94 cM mouse Y861-p 447965 PTGNQHIyQPVGKPD phosphorylation carcinogenesis, induced; apoptosis, inhibited; cytoskeletal reorganization 17289681; 33730293 75 21 307 regulates tumor growth and blood vessel density; inhibits necrosis; Y861 phosphorylation is necessary for cell survival after osmotic stress. +HTT Huntingtin Cytoskeletal P42858 3064 4p16.3 human T3-p 10206804 _____MAtLEKLMKA protein stabilization; molecular association, regulation; protein conformation Huntingtin(INDUCES) 19710014; 28334491; 29162692; 30185623; 33256402 13 4 0 regulation of Huntingtin interaction and aggregation in lipid system +PTEN PTEN Carbohydrate Metabolism - inositol phosphate; EC 3.1.3.16; EC 3.1.3.48; EC 3.1.3.67; Motility/polarity/chemotaxis; Nuclear receptor co-regulator; PHOSPHATASE; Phosphatase, lipid; Tumor suppressor P60484 5728 10q23.31 human Y138-p 4000968 TGVMICAyLLHRGKF phosphorylation transcription, inhibited; signaling pathway regulation 31461649 3 0 0 induces NKAP dephosphorylation and suppresses RELA phosphorylation, regulates PTEN/NKAP/NF-KB/PDHK1 signaling +CLIP1 Restin iso3 Cytoskeletal P30622-2 6249 12q24.31 human T287-p 483203 KIGFPSTtPAKAKAN protein stabilization; intracellular localization cell cycle regulation; carcinogenesis, induced; apoptosis, inhibited; transcription, altered 23661607 3 6 3 induce AR stabilization and nuclear translocation/accumulation +CERK CERK EC 2.7.1.138; Kinase, lipid; Lipid Metabolism - sphingolipid Q8TCT0 64781 22q13.31 human S340-p 11485302 PAQHTVGsPRDRKPC protein stabilization 19899769 2 1 0 +FOXM1 FOXM1 DNA-binding; Transcription factor Q08050 2305 12p13.33 human K614-ac 57807001 PISSTPSkSVLPRTP activity, induced; protein stabilization; molecular association, regulation; phosphorylation carcinogenesis, induced; cell growth, induced; transcription, induced DNA(NOT_REPORTED) 27542221 1 1 0 +ARL8B ARL8B G protein, monomeric; G protein, monomeric, ARF Q9NVJ2 55207 3p26.1 human K141-ub 3934083 LPNALDEkQLIEKMN Arf protein degradation signaling pathway regulation 27808481 1 12 96 regulation of EGF-EGFR endocytic trafficking +ADD1 ADD1 Cytoskeletal; Motility/polarity/chemotaxis P35611 118 4p16.3 human S716-p 449828 GSPGKSPsKKKKKFR molecular association, regulation; intracellular localization cytoskeletal reorganization KPNA1(DISRUPTS) 21736685; 9679146 5 1 0 +STIM1 STIM1 Calcium-binding; Endoplasmic reticulum; Membrane protein, integral Q13586 6786 11p15.4 human Y361-p 25755095 THEVEVQyYNIKKQN SOAR molecular association, regulation; intracellular localization ORAI1(INDUCES) 28218251 2 0 1 Store operated calcium entry, increased vascular permeability +GRK2 GRK2 EC 2.7.11.15; KINASE; Kinase, protein; Protein kinase, AGC; Protein kinase, Ser/Thr (non-receptor) P21146 282682 cow Y13-p 456872 AVLADVSyLMAMEKS enzymatic activity, induced 18463167 5 0 0 +Nkx2-5 NKX2-5 DNA-binding P42582 18091 17 A3.3|17 13.6 cM mouse K182-ac 62518200 KLTSTQVkIWFQNRR Homeodomain molecular association, regulation transcription, induced TBX5(INDUCES); SRF(INDUCES) 27819261 1 1 0 deacetylation inhibits interactions +Tsc2 TSC2 Cell cycle regulation; GAP; GAP, misc.; Nuclear receptor co-regulator; Tumor suppressor P49816 24855 10q12 rat Y1573-p 448502 NEHGSYRyTEFLTGL Rap_GAP activity, induced; molecular association, regulation cell growth, altered TSC1(INDUCES) 11290735 2 0 1 +TGFBR1 TGFBR1 EC 2.7.11.30; KINASE; Kinase, protein; Membrane protein, integral; Protein kinase, Ser/Thr (receptor); Protein kinase, TKL; Receptor, misc. P36897 7046 9q22.33 human S172-p 4331006 SLDRPFIsEGTTLKD cell growth, altered 8576253 1 0 0 +PPARG PPAR-gamma iso2 DNA-binding; Nuclear receptor; Transcription factor P37231-2 5468 3p25.2 human K240-ac 25780500 ARAILTGkTTDKSPF transcription, induced 28416226 4 1 0 +Mip AQP0 Channel, misc.; Membrane protein, integral; Membrane protein, multi-pass; Transporter, aquaporin family P09011 25480 7q11 rat S243-p 451791 KGARPSDsNGQPEGT molecular association, regulation 22194645 2 0 0 No differences in the interaction with filensin between the AQP0 COOH-terminal peptide and its pseudophosphorylated proteins +CD274 PD-L1 Membrane protein, integral Q9NZQ7 29126 9p24.1 human T180-p 63237406 QVLSGKTtTTNSKRE C2-set_2 protein degradation; ubiquitination 27572267 1 0 0 +CTCF CTCF C2H2-type zinc finger protein; Transcription factor; Tumor suppressor P49711 10664 16q22.1 human K20-ac 3979891 SETFIKGkERKTYQR cell differentiation, induced; transcription, induced 36117192 1 0 4 differentiation of embryoid bodies, regulates genes associated with early cardiac mesoderm differentiation, facilitates enhancer-promoter interactions +FGFR1 FGFR1 EC 2.7.10.1; KINASE; Kinase, protein; Membrane protein, integral; Oncoprotein; Protein kinase, TK; Protein kinase, tyrosine (receptor) P11362 2260 8p11.23 human Y677-p 447920 EALFDRIyTHQSDVW PK_Tyr_Ser-Thr molecular association, regulation STAT3(INDUCES) 20388777 2 0 0 +ERCC2 ERCC2 EC 3.6.4.12; Helicase P18074 2068 19q13.32 human T425-p 1878257800 IEPFDDRtPTIANPI intracellular localization cell cycle regulation 35977011 1 1 0 regulates Eg5 localization +HNRNPK hnRNP K RNA splicing; RNA-binding; Spliceosome P61978 3190 9q21.32 human S216-p 450148 ILDLISEsPIKGRAQ activity, induced; molecular association, regulation; intracellular localization transcription, altered TDP-43(INDUCES) 11259409; 25410660 5 71 5 +PES1 PES1 Nucleolus; RNA-binding; Translation O00541 23481 22q12.2 human K517-sm 55435545 RVMAGTLkLEDKQRL protein stabilization; molecular association, regulation; ubiquitination cell cycle regulation; carcinogenesis, induced; cell growth, induced; transcription, induced; signaling pathway regulation TRIM23(DISRUPTS) 27409667 1 3 0 inhibits ubiquitination, induces estrogen signaling pathway +NPR1 ANPA EC 4.6.1.2; Guanylyl cyclase; KINASE; Kinase, protein; Lyase; Membrane protein, integral; Nucleotide Metabolism - purine; Protein kinase, RGC; Protein kinase, dual-specificity (receptor); Receptor, misc. P16066 4881 1q21.3 human S519-p 14364503 WEDVEPSsLERHLRS enzymatic activity, induced 28416574 2 2 0 +TRIM28 TIF1B EC 6.3.2.-; KINASE; Kinase, protein; Ligase; Nuclear receptor co-regulator; Protein kinase, atypical; SUMO LIGASE; SUMO ligase; Transcription, coactivator/corepressor; UBIQUITIN LIGASE; Ubiquitin conjugating system; Ubiquitin ligase Q13263 10155 19q13.43 human K554-sm 2798310 LAGMAIVkEEETEAA molecular association, regulation; acetylation; methylation cell growth, induced; transcription, inhibited CHD-3(INDUCES) 17079232; 17942393; 21642969; 31391303 5 2 0 loss of TF1B sumoylation induces dsRNA-activated IFN-mediated defenses that rely on RIG-I, MAVS, TBK1, and JAK1 transcription, SUMOylated TIF1B Is required to support efficient virus replication +ENDOG ENDOG Apoptosis; Deoxyribonuclease; EC 3.1.30.-; Mitochondrial; Ribonuclease Q14249 2021 9q34.11 human T128-p 1871762501 VHAYHRAtNADYRGS Endonuclease_NS protein degradation; molecular association, regulation autophagy, induced; signaling pathway regulation 14-3-3 gamma(INDUCES) 33473107 1 0 0 binding to 14-3-3 gamma inhibits 14-3-3 gamma binding to TSC2 and Vps34, inhibits mTOR signaling pathway, induces SQSTM1 degradation +Grk2 GRK2 EC 2.7.11.15; KINASE; Kinase, protein; Protein kinase, AGC; Protein kinase, Ser/Thr (non-receptor) Q99MK8 110355 19 A|19 3.98 cM mouse Y92-p 456873 FYEEIKKyEKLETEE RGS cell motility, altered 18369319 5 0 0 +CD6 CD6 Cell surface; Membrane protein, integral P30203 923 11q12.2 human Y629-p 450238 STSSGEWyQNFQPPP activity, induced; molecular association, regulation SLP76(INDUCES); GRB2(INDUCES); GADS(INDUCES); TSAd(INDUCES) 27896837; 28289074 3 1 0 +MAP3K20 ZAK EC 2.7.11.25; KINASE; Kinase, protein; Protein kinase, Ser/Thr (non-receptor); Protein kinase, TKL Q9NYL2 51776 2q31.1 human T161-p 455377 ASRFHNHtTHMSLVG PK_Tyr_Ser-Thr enzymatic activity, induced 15342622 1 0 0 +Nlgn1 NLGN1 Membrane protein, integral Q62765 rat Y782-p 1008111 RTACPPDyTLAMRRS molecular association, regulation signaling pathway regulation PSD-95(INDUCES); gephyrin(DISRUPTS) 23770246 3 1 0 Binding to gephyrin induces inhibitory synapses and binding to PSD-95 induces excitatory synapses. +RXRA RXRA DNA-binding; Motility/polarity/chemotaxis; Nuclear receptor P19793 6256 9q34.2 human S27-p 3188103 TSPTGRGsMAAPSLH Nuc_recep-AF1 activity, inhibited transcription, altered 11162439 1 0 0 +FOXO1 FOXO1A DNA-binding; Nuclear receptor co-regulator; Oncoprotein; Transcription factor Q12778 2308 13q14.11 human K294-ac 15625100 SPGSQFSkWPASPGS intracellular localization; phosphorylation 20519497 1 0 0 +VDR VDR DNA-binding; Nuclear receptor; Transcription factor P11473 7421 12q13.11 human S208-p 456982 SFSNLDLsEEDSDDP molecular association, regulation transcription, induced; transcription, altered MED1(INDUCES) 17368182; 8622969 5 0 0 +Tgfbr1 TGFBR1 EC 2.7.11.30; KINASE; Kinase, protein; Membrane protein, integral; Protein kinase, Ser/Thr (receptor); Protein kinase, TKL; Receptor, misc. Q64729 21812 4 B1|4 26.02 cM mouse Y182-p 7791190 TTLKDLIyDMTTSGS TGF_beta_GS molecular association, regulation carcinogenesis, induced; cell motility, induced; transcription, induced; signaling pathway regulation TGFBR2(INDUCES) 35538070 2 1 2 induces the TGF?/Smad2/PTHLH pathway +YAP1 YAP1 Oncoprotein; Transcription, coactivator/corepressor P46937 10413 11q22.1 human S138-p 485036 SLQLGAVsPGTLTPT molecular association, regulation; intracellular localization cell cycle regulation; apoptosis, inhibited TEAD4(DISRUPTS) 24812269; 26933062 4 30 79 mitotic shift, important for proper mitosis and cytokinesis +NFKBIA IkB-alpha DNA-binding; Inhibitor P25963 4792 14q13.2 human T299-p 456335 ESEFTEFtEDELPYD protein degradation 8657113 2 0 0 S283/T291/T299A triple mutant showed increased IkB-alpha stability. +CFTR CFTR Channel, chloride; EC 3.6.3.49; Hydrolase; Membrane protein, integral; Membrane protein, multi-pass; Transporter; Transporter, ABC family P13569 1080 7q31.2 human S813-p 449983 DIYSRRLsQETGLEI CFTR_R activity, induced; molecular association, regulation; enzymatic activity, inhibited; protein conformation CFTR(INDUCES) 11053017; 14602047; 1716180; 32102849; 36695813 13 6 0 +FOXO1 FOXO1A DNA-binding; Nuclear receptor co-regulator; Oncoprotein; Transcription factor Q12778 2308 13q14.11 human T649-p 35486505 PHSVKTTtHSWVSG_ intracellular localization transcription, induced 25065674 1 0 0 +Nr3c1 GR DNA-binding; Mitochondrial; Nuclear receptor; Transcription factor P06537 14815 18 B3|18 21.09 cM mouse S243-p 451796 LIDENLLsPLAGEDD GCR activity, inhibited transcription, induced; transcription, inhibited; signaling pathway regulation 21994940; 25477995; 30738183 39 9 1 +CDK1 CDK1 Cell cycle regulation; EC 2.7.11.22; EC 2.7.11.23; KINASE; Kinase, protein; Motility/polarity/chemotaxis; Protein kinase, CMGC; Protein kinase, Ser/Thr (non-receptor) P06493 983 10q21.2 human S39-p 455465 MKKIRLEsEEEGVPS Pkinase cell cycle regulation; DNA repair, induced 15788687; 36189922 3 12 26 +Itch ITCH EC 6.3.2.-; EC 6.3.2.19; Ligase; UBIQUITIN LIGASE; Ubiquitin conjugating system; Ubiquitin ligase Q8C863 16396 2 H1|2 76.94 cM mouse S232-p 459623 RPASVNGsPSTNSDS activity, induced; protein stabilization; protein conformation 16446428 1 0 0 +NGFR NGFR Membrane protein, integral; Receptor, misc. P08138 4804 17q21.33 human S425-p 41389903 CSESTATsPV_____ molecular association, regulation carcinogenesis, inhibited CLIM1(DISRUPTS) 26119933 1 1 0 NGFR mediated glioma invasion +USF2 USF2 DNA-binding; Transcription factor Q15853 7392 19q13.12 human S222-p 9285181 APRTHPYsPKIDGTR protein stabilization carcinogenesis, induced; cell motility, induced; cell growth, induced; transcription, induced 31013770 1 8 11 Increase in USF2 mRNA expresssion was observed in MDA-MB-231 CDK5 knockout cells +IFNAR2 IFNAR2 Membrane protein, integral; Receptor, cytokine P48551 3455 21q22.11 human Y306-p 26416401 MDMVEVIyINRKKKV molecular association, regulation transcription, induced; signaling pathway regulation STAT2(DISRUPTS) 34813358 2 0 0 induces STAT phosphorylation and signaling +PPP5C PPP5C EC 3.1.3.16; PHOSPHATASE; Protein phosphatase, Ser/Thr (non-receptor) P53041 5536 19q13.32 human K185-ub 21182254 GPKLEDGkVTISFMK PPP5 protein degradation; ubiquitination 29141220 1 5 0 +Dpysl2 CRMP-2 Microtubule-binding; Motility/polarity/chemotaxis P47942 25416 15p12 rat T509-p 448083 PVCEVSVtPKTVTPA molecular association, regulation CRMP-4(DISRUPTS); CRMP-1(DISRUPTS); ROCK2(DISRUPTS); SLC25A4(DISRUPTS) 18220421; 24036111 16 63 34 +RAB29 RAB29 G protein; G protein, monomeric; G protein, monomeric, Rab O14966 8934 1q32.1 human T71-p 406855300 IAGQERFtSMTRLYY Ras activity, inhibited 29212815 3 0 0 Rab29 phosphorylation may decrease its ability to activate LRRK2 +Oprk1 KOR-1 GPCR, family 1; Membrane protein, integral; Membrane protein, multi-pass; Receptor, GPCR P33534 18387 1 A1|1 1.89 cM mouse T363-p 52467202 STNRVRNtVQDPASM receptor internalization, induced; intracellular localization; phosphorylation 26635353; 35652052 3 1 0 +CAP1 CAP1 Actin-binding; Cytoskeletal Q01518 10487 1p34.2 human S308-p 485063 SAPKPQTsPSPKRAT activity, induced carcinogenesis, induced; cell motility, induced; cell growth, induced; cell adhesion, induced; apoptosis, inhibited; transcription, induced; cytoskeletal reorganization 30123351; 30894654; 34636991 4 46 29 +Ddx41 DDX41 EC 3.6.4.13; Helicase; RNA splicing; RNA-binding; Spliceosome Q91VN6 72935 13|13 B1 mouse K9-ub 27992511 EDSEPERkRARADEA protein degradation transcription, inhibited 23222971 1 0 0 +MAPK7 ERK5 EC 2.7.11.24; KINASE; Kinase, protein; Protein kinase, CMGC; Protein kinase, Ser/Thr (non-receptor) Q13164 5598 17p11.2 human K184-ub 63128906 QVIHRDLkPSNLLVN Pkinase molecular association, regulation; enzymatic activity, induced transcription, induced Fos(INDUCES) 28131816 1 2 0 +TLR8 TLR8 Membrane protein, integral; Receptor, misc. Q9NR97 51311 Xp22.2 human Y1030-p 953800 LTENDSRyNNMYVDS TIR molecular association, regulation signaling pathway regulation PIK3R1(INDUCES) 17868034 1 0 0 inhibits IL-8 synthesis +RELA NFkB-p65 DNA-binding; Nuclear receptor co-regulator; Transcription factor Q04206 5970 11q13.1 human K195-ub 10304900 APNTAELkICRVNRN RHD_dimer protein degradation; activity, inhibited transcription, altered 19706600 2 2 0 TNF alpha - induced RelA polyubiquitination and degradation +Grik2 GluR6 Channel, calcium; Channel, ligand-gated; Membrane protein, integral; Membrane protein, multi-pass P42260 54257 20q13 rat S868-p 478417 MVEELRMsLKCQRRL receptor recycling, inhibited; sumoylation; molecular association, regulation exocytosis, inhibited; endocytosis, induced 14-3-3 theta(INDUCES) 22089239; 23861400; 28636947 7 0 0 increases sumoylation; recycled more ef?ciently to the cell surface +TPX2 TPX2 Cell cycle regulation; Microtubule-binding Q9ULW0 22974 20q11.21 human S322-p 31890658 RTFDETVsTYVPLAQ intracellular localization KPNB1(INDUCES) 29276125 1 1 0 accumulation of TPX2 at the prophase centrosome +TRIP13 TRIP13 Nuclear receptor co-regulator; Transcription, coactivator/corepressor Q15645 9319 5p15.33 human Y56-p 450833 HNIVFGDyTWTEFDE protein stabilization DNA repair, induced; carcinogenesis, induced; cell growth, induced; signaling pathway regulation 32860853; 34111559 2 1 4 +KCND3 Kv4.3 Channel, potassium; Membrane protein, integral; Membrane protein, multi-pass Q9UK17 3752 1p13.2 human Y108-p 23045802 GKLHYPRyECISAYD BTB_2 activity, induced 22198508 1 0 0 positive regulation of Kv4.3 channel and cellular electrical activity +MC4R MC4R GPCR, family 1; Membrane protein, integral; Membrane protein, multi-pass; Receptor, GPCR P32245 4160 18q21.32 human T312-p 449101 RSQELRKtFKEIICC receptor recycling, inhibited; intracellular localization; receptor internalization, altered; activity, inhibited 12639913; 22544740 2 0 0 retains MC4R in the endosomal compartment +TP53 p53 Activator; DNA-binding; Motility/polarity/chemotaxis; Nuclear receptor co-regulator; Transcription factor; Tumor suppressor P04637 7157 17p13.1 human K139-ub 486295 KMFCQLAkTCPVQLW P53 protein degradation; intracellular localization 17371868; 31492752 2 1 0 +Ccnd2 CCND2 Cell cycle regulation; Motility/polarity/chemotaxis P30280 12444 6 F3|6 61.92 cM mouse K270-ub 1872854200 EQHNAGSkSVEDPDQ Cyclin_C protein degradation cell cycle regulation; carcinogenesis, inhibited 22323446 1 0 0 +APLP2 APLP2 Cell surface; DNA-binding; Membrane protein, integral; Receptor, misc. Q06481 334 11q24.3 human T736-p 451599 VEVDPMLtPEERHLN APP_amyloid molecular association, regulation APBA2(INDUCES); Fe65(INDUCES) 11517218; 14970211 3 2 1 Phosphorylation of APP and APLP2 was enhanced by osmotic stress, binding to ABPA2, and JNK (in vitro). +Cry2 CRY2 DNA-binding; Lyase Q9R194 12953 2|2 E1 mouse K474-ub 12369753 NAPESVQkAAKCIIG FAD_binding_7 protein degradation; intracellular localization 23452856 1 4 1 +FLI1 FLI1 DNA-binding; Oncoprotein; Transcription factor Q01543 2313 11q24.3 human T312-p 6406002 TNGEFKMtDPDEVAR Ets protein degradation; molecular association, regulation; acetylation transcription, induced; transcription, inhibited; transcription, altered p300(DISRUPTS) DNA(INDUCES) 19158279; 21321929; 24058639; 25707716 6 0 0 inhibited transcription of CDH5, PECAM1, PDGFB and MMP9 genes, impaired leaky vessels +Bad BAD Apoptosis Q61337 12015 19|19 A mouse S26-p 27530804 KSDPGIRsLGSDAGG molecular association, regulation; intracellular localization; activity, inhibited; phosphorylation apoptosis, inhibited 14-3-3 beta(INDUCES); Bcl-xL(DISRUPTS) 23332762 1 1 0 induces phosphorylation at S112, S136 and S155 +Scn5a SCN5A Channel, sodium; Membrane protein, integral; Membrane protein, multi-pass Q9JJV9 20271 9 F3|9 71.33 cM mouse S1988-p 235474402 DSVTRATsDNLPVRA activity, induced; molecular association, regulation FGF13(DISRUPTS); Calmodulin(DISRUPTS) 28882890 2 2 0 impairs FGF13-dependent regulation of NaV1.5 channel inactivation +Ntrk2 TrkB EC 2.7.10.1; KINASE; Kinase, protein; Membrane protein, integral; Protein kinase, TK; Protein kinase, tyrosine (receptor) P15209 18212 13 B1|13 31.2 cM mouse Y515-p 448813 PVIENPQyFGITNSQ receptor internalization, altered; phosphorylation; enzymatic activity, induced neural plasticity; cell growth, inhibited; cell differentiation, induced; signaling pathway regulation; cell growth, altered 11877382; 14581459; 21562256; 31914388 23 2 40 MEK/ERK1/1 pathway +INSR INSR EC 2.7.10.1; KINASE; Kinase, protein; Membrane protein, integral; Protein kinase, TK; Protein kinase, tyrosine (receptor) P06213 3643 19p13.2 human Y1190-p 447682 DIYETDYyRKGGKGL PK_Tyr_Ser-Thr molecular association, regulation; receptor internalization, altered; phosphorylation; enzymatic activity, induced transcription, altered IRS2(INDUCES); PTP1B(INDUCES) 10852715; 11850117; 1658004; 22081023; 8024702; 8999839; 9195949 46 14 107 prolactin transcription +KDM1A LSD1 DEMETHYLASE; Demethylase; EC 1.-.-.-; Nuclear receptor co-regulator; Oxidoreductase; Transcription factor O60341 23028 1p36.12 human K277-ub 1881258600 IKPLPTKkTGKVIII protein degradation; molecular association, regulation carcinogenesis, induced; transcription, altered RCOR1(DISRUPTS); CDC6(INDUCES) 34050636 1 1 0 disrupts LSD1 association from RCOR1/HDACs complex +ATG5 ATG5 Apoptosis; Autophagy; Ubiquitin conjugating system Q9H1Y0 9474 6q21 human T101-p 23084709 SALPWNItVHFKSFP APG5 protein stabilization; molecular association, regulation; ubiquitination carcinogenesis, induced; autophagy, induced; cell growth, induced; apoptosis, inhibited ATG16L1(INDUCES); USP13(INDUCES) 32186433; 36528756 2 1 1 induces deubiquitination; inhibits ubiquitination +RELA NFkB-p65 DNA-binding; Nuclear receptor co-regulator; Transcription factor Q04206 5970 11q13.1 human K218-ac 459095 EIFLLCDkVQKEDIE RHD_dimer intracellular localization carcinogenesis, induced; transcription, induced 19345327; 27007123 7 0 0 induces JCV activation +NFKB1 NFkB-p105 DNA-binding; Transcription factor P19838 4790 4q24 human K441-ac 465127 TMDTESKkDPEGCDK molecular association, regulation; intracellular localization DNA(INDUCES) 11739381 1 1 0 nuclear translocation +RARA RARA DNA-binding; Nuclear receptor; Oncoprotein; Transcription factor P10276 5914 17q21.2 human K166-sm 10902802 RNDRNKKkKEVPKPE transcription, induced 19850744 1 0 0 +IKBKG IKKG Adaptor/scaffold; Protein kinase, regulatory subunit Q9Y6K9 8517 Xq28 human K399-ub 486357 PPDFCCPkCQYQAPD zf_C2H2_10 enzymatic activity, induced transcription, induced; signaling pathway regulation 14695475; 15125833; 17363905; 17728323; 23871670 5 0 0 K-R mutants cause embryonic lethality, complemented by TNFR1 loss, regulates NF-kB activation and NOD2 signaling in response to innate immune agonists +Gphn gephyrin Adaptor/scaffold; EC 2.10.1.1; EC 2.7.7.75 Q03555 64845 6q24 rat K161-sm 1876579502 IINLPGSkKGSQECF MoCF_biosynth molecular association, regulation gephyrin(DISRUPTS) 35307349 1 0 0 +Kcnj5 GIRK4 Channel, potassium; Membrane protein, integral; Membrane protein, multi-pass P48548 29713 8q21 rat Y53-p 3146603 GKKPRQRyMEKTGKC activity, inhibited 10833508 1 0 0 +RNF157 RNF157 UBIQUITIN LIGASE; Ubiquitin conjugating system; Ubiquitin ligase Q96PX1 114804 17q25.1 human S662-p 5202125 QRRRLSSsSLEDSET protein degradation; molecular association, regulation; ubiquitination CDH1(INDUCES) 28655764 1 2 2 +IL27RA IL27RA Membrane protein, integral Q6UWB1 9466 19p13.12 human Y613-p 478855 TAPLDSGyEKHFLPT molecular association, regulation transcription, altered STAT1(INDUCES) 33871355 1 1 2 induces STAT1 phosphorylation +NUP98 NUP98 iso2 Motility/polarity/chemotaxis; Nucleoporin P52948-2 4928 11p15.4 human S822-p 3150833 TSRCLIKsPDRLADI Nucleoporin2 intracellular localization 21335236 1 28 18 as multiple sites (13PM) mutant +EGLN2 EGLN2 EC 1.14.11.29; Oxidoreductase Q96KS0 112398 19q13.2 human T405-p 50777944 VPVSQPPtPT_____ protein degradation; molecular association, regulation; ubiquitination FBXW7(INDUCES) 28036276 1 3 0 +PRKCA PKCA EC 2.7.11.13; KINASE; Kinase, protein; Oncoprotein; Protein kinase, AGC; Protein kinase, Ser/Thr (non-receptor) P04409 282001 cow T494-p 449889 EHMMDGVtTRTFCGT Pkinase enzymatic activity, induced 8349635 2 1 4 +NTRK2 TrkB EC 2.7.10.1; KINASE; Kinase, protein; Membrane protein, integral; Protein kinase, TK; Protein kinase, tyrosine (receptor) Q16620 4915 9q21.33 human Y706-p 448811 RDVYSTDyYRVGGHT PK_Tyr_Ser-Thr activity, induced; molecular association, regulation; phosphorylation carcinogenesis, induced; signaling pathway regulation PTP1B(INDUCES) 15494731; 25288805; 33820494 15 0 49 GKAP1-NTRK2 activity induced +WRN WRN Cell cycle regulation; DNA repair, damage; DNA-binding; EC 3.6.4.12; Helicase; Nucleolus Q14191 7486 8p12 human K366-ac 14512102 GEDVLGNkVERKEDG protein stabilization; ubiquitination 20428248 1 1 0 inhibits ubiquitination +IGF1R IGF1R EC 2.7.10.1; KINASE; Kinase, protein; Membrane protein, integral; Protein kinase, TK; Protein kinase, tyrosine (receptor) P08069 3480 15q26.3 human K1150-sm 12723516 VAEDFTVkIGDFGMT PK_Tyr_Ser-Thr intracellular localization transcription, induced DNA(INDUCES) 20145208 1 0 0 enhances nuclear localization and accumulation of IGF1-R, binding to DNA enhancer regions and inducing transcription. +EDNRA EDNRA GPCR, family 1; Membrane protein, integral; Membrane protein, multi-pass; Motility/polarity/chemotaxis; Receptor, GPCR P25101 1909 4q31.22-q31.23 human T417-p 2911709 HDQNNHNtDRSSHKD receptor desensitization, induced 24064210 1 1 0 Lack of S397, T403 and S404 influences desensitization to a greater extent compared than S391, S393, and T396 +BBC3 PUMA Apoptosis; Mitochondrial Q9BXH1 27113 19q13.32 human Y172-p 29674705 PSPWRVLyNLIMGLL PUMA protein degradation; intracellular localization cell growth, induced; apoptosis, inhibited 24236056 1 0 1 +Polr2a POLR2A EC 2.7.7.48; EC 2.7.7.6; Nucleotide Metabolism - purine; Nucleotide Metabolism - pyrimidine; Transcription initiation complex; Transferase P08775 20020 11 B3|11 42.86 cM mouse K1908-ub 2134721 VYTPTSPkYSPTSPT RNA_pol_Rpb1_R protein degradation 17526739 1 1 0 +CDK16 CDK16 Cell cycle regulation; EC 2.7.11.22; KINASE; Kinase, protein; Motility/polarity/chemotaxis; Protein kinase, CMGC; Protein kinase, Ser/Thr (non-receptor) Q00536 5127 Xp11.3 human S119-p 453450 EDINKRLsLPADIRL molecular association, regulation cytoskeletal reorganization 14-3-3 beta(INDUCES); 14-3-3 zeta(INDUCES); 14-3-3 gamma(INDUCES) 12154078 4 60 0 +HNRNPK hnRNP K RNA splicing; RNA-binding; Spliceosome P61978 3190 9q21.32 human S302-p 457408 GRGGRGGsRARNLPL molecular association, regulation; phosphorylation apoptosis, inhibited PKCD(INDUCES); PKCD(DISRUPTS) 10329716; 25104022 4 0 0 methylation of R296 and R299 suppress S302 phosphorylation, R296/R299 methylation reduces apoptosis in U2OS-K- 2RK cells after DNA damage +NOS3 eNOS Amino Acid Metabolism - arginine and proline; EC 1.14.13.39; Oxidoreductase P29474 4846 7q36.1 human T495-p 447885 TGITRKKtFKEVANA molecular association, regulation; intracellular localization; enzymatic activity, inhibited Calmodulin(DISRUPTS) 11397791; 12574113; 21757745; 33539947; 33578126; 35074481; 35617030; 35884891 82 2 1 +H1-2 H1C DNA-binding P16403 3006 6p22.2 human K34-m1 50094511 KAGGTPRkASGPPVS molecular association, regulation 28392790 1 1 1 increased interaction with NS2 +PTEN PTEN Carbohydrate Metabolism - inositol phosphate; EC 3.1.3.16; EC 3.1.3.48; EC 3.1.3.67; Motility/polarity/chemotaxis; Nuclear receptor co-regulator; PHOSPHATASE; Phosphatase, lipid; Tumor suppressor P60484 5728 10q23.31 human Y155-p 4000973 AQEALDFyGEVRTRD protein stabilization; molecular association, regulation WWP2(DISRUPTS) 21532586; 22891331 3 1 0 +ESPL1 separase EC 3.4.22.49; Protease Q14674 9700 12q13.13 human S1153-p 40666500 CDCSLCAsPVLTAVC molecular association, regulation PIN1(INDUCES) 25921067 1 0 0 +RET Ret EC 2.7.10.1; KINASE; Kinase, protein; Membrane protein, integral; Oncoprotein; Protein kinase, TK; Protein kinase, tyrosine (receptor) P07949 5979 10q11.21 human Y981-p 450703 DNCSEEMyRLMLQCW PK_Tyr_Ser-Thr molecular association, regulation; enzymatic activity, induced Src(INDUCES) 11956105; 14766744 7 1 0 +Blnk BLNK Adaptor/scaffold Q9QUN3 17060 19 C3|19 34.26 cM mouse K38-ub 23303204 GIMDKIKkLKVKGPP molecular association, regulation; ubiquitination 14-3-3 beta(INDUCES) 22334673 1 0 0 Thr-152 phosphorylation induces BLNK ubiquitination at K37, K38, K42. +Ppp1r1a PPP1R1A Inhibitor; Protein phosphatase, regulatory subunit P19103 58977 7q36 rat T35-p 447759 QIRRRRPtPATLVLT DARPP-32 activity, inhibited; phosphorylation 21447388 14 4 0 induces PLB dephosphorylation +RELA NFkB-p65 DNA-binding; Nuclear receptor co-regulator; Transcription factor Q04206 5970 11q13.1 human K315-ac 1985901 TFKSIMKkSPFSGPT molecular association, regulation; intracellular localization carcinogenesis, induced; cell motility, induced; cell growth, induced; transcription, induced; transcription, inhibited; transcription, altered DNA(DISRUPTS) 18263619; 20064247; 23087373; 28167529; 31939185; 34626802 7 1 0 recruited to the IL-8 promoter +NDC80 HEC1 Cell cycle regulation O14777 10403 18p11.32 human T49-p 474512 KLSINKPtSERKVSL cell cycle regulation; cytoskeletal reorganization 17129782; 35878017 2 1 0 +POU5F1 Oct4 DNA-binding; Transcription factor Q01860 5460 6p21.33 human S236-p 6738001 ARKRKRTsIENRVRG Homeodomain molecular association, regulation transcription, inhibited DNA(DISRUPTS) 22474382 1 3 0 +STXBP5L STXBP5L Q9Y2K9 9515 3q13.33 human S812-p 34668140 TEENRENsYNRSRSS Lgl_C protein degradation 25002582 1 1 0 ; in a multiple residue S->D mutant +ATG9A ATG9A Autophagy; Membrane protein, integral; Membrane protein, multi-pass; Vesicle Q7Z3C6 79065 2q35 human S761-p 4722321 QSIPRSAsYPCAAPR molecular association, regulation autophagy, induced 14-3-3 zeta(INDUCES) 25266655 1 10 11 +HERC2 HERC2 EC 6.3.2.-; EC 6.3.2.19; Ligase; Mitochondrial; UBIQUITIN LIGASE; Ubiquitin conjugating system; Ubiquitin ligase O95714 8924 15q13.1 human T4827-p 12122400 DSFASDStQDYLTGH molecular association, regulation; ubiquitination RNF8(INDUCES) 20023648; 22508508 2 0 0 +NR1I2 PXR DNA-binding; Nuclear receptor O75469 8856 3q13.33 human S221-p 1868023601 QLRGEDGsVWNYKPP molecular association, regulation transcription, inhibited SMRT(INDUCES); SRC-1(DISRUPTS); N-CoR1(INDUCES); GRIP1(DISRUPTS); RKIP(DISRUPTS); RXRA(DISRUPTS) 32205367 1 1 0 +MYH9 MYH9 Actin-binding; Motility/polarity/chemotaxis; Motor P35579 4627 22q12.3 human Y1408-p 462335 HEEKVAAyDKLEKTK Myosin_tail_1 carcinogenesis, inhibited; cell motility, inhibited 31735331 1 20 916 upregulates EGFR expression +U2AF1 U2AF1 RNA processing; RNA splicing; RNA-binding; Spliceosome Q01081 7307 21q22.3 human S34-p 1868227100 CRHGDRCsRLHNKPT zf-CCCH phosphorylation carcinogenesis, inhibited; RNA splicing, altered; cell differentiation, induced; transcription, inhibited; signaling pathway regulation 31011167 1 0 0 inhibits phosphorylation of p38, ERK, IRAK1, IKK and p65, regulates innate immune signaling and NF-kB signaling +SQSTM1 SQSTM1 Autophagy; Nuclear receptor co-regulator; Ubiquitin conjugating system Q13501 8878 5q35.3 human S28-p 3195656 RRFSFCCsPEPEAEA PB1 protein degradation; molecular association, regulation; ubiquitination; intracellular localization carcinogenesis, induced; autophagy, induced; cell growth, induced; apoptosis, inhibited; transcription, induced TRIM21(DISRUPTS); SQSTM1(INDUCES); KEAP1(INDUCES) 31032410 1 10 7 inhibits ubiquitination, regulates Nrf2 localization +Rasd1 RASD1 G protein; G protein, monomeric; G protein, monomeric, RasD O35626 19416 11|11 B1.3 mouse S253-p 50402002 APFARRPsVHSDLMY activity, inhibited signaling pathway regulation 26358293 1 2 0 inhibits S-nitrosylation of RASD1, prevents NO-mediated iron uptake pathway via RASD1 (aka Dexras1) +PGRMC1 PGRMC1 Membrane protein, integral; Receptor, misc. O00264 10857 Xq24 human S57-p 452526 QPAASGDsDDDEPPP apoptosis, altered; cell growth, induced 18922159; 29069804 3 62 1 +RB1 Rb Nuclear receptor co-regulator; Oncoprotein; Transcription, coactivator/corepressor; Tumor suppressor P06400 5925 13q14.2 human S780-p 447978 STRPPTLsPIPHIPR Rb_C protein degradation; molecular association, regulation; activity, inhibited cell cycle regulation; carcinogenesis, induced; carcinogenesis, inhibited; cell growth, inhibited; transcription, induced; transcription, altered; cell growth, induced; apoptosis, inhibited; transcription, inhibited; cell growth, altered ID2(DISRUPTS); E2F1(DISRUPTS); E2F1(INDUCES) 11641415; 11746527; 14676836; 15028555; 15619620; 17478427; 19225156; 21880723; 22279936; 23429262; 24466208; 31615938; 33556114; 33767437; 33793628; 34158578; 34247189; 35437308; 35513564; 36372230; 9315635 98 17 128 +NPR1 ANPA EC 4.6.1.2; Guanylyl cyclase; KINASE; Kinase, protein; Lyase; Membrane protein, integral; Nucleotide Metabolism - purine; Protein kinase, RGC; Protein kinase, dual-specificity (receptor); Receptor, misc. P16066 4881 1q21.3 human T545-p 447516 SNYGSLLtTEGQFQV PK_Tyr_Ser-Thr activity, induced; enzymatic activity, induced 28416574; 9528788 3 2 0 +Myod1 MyoD DNA-binding; RNA splicing; Transcription factor P10085 17927 7 B3|7 30.03 cM mouse Y156-p 18755302 ILRNAIRyIEGLQAL HLH protein stabilization; molecular association, regulation transcription, altered FBXO32(DISRUPTS) 21454680 1 1 0 stimulates skeletal myogenesis +Scin SCIN Motility/polarity/chemotaxis Q60604 20259 12|12 B1 mouse K189-ac 1883618700 CNKYERLkASQVAIG cytoskeletal reorganization 37450577 1 1 0 +MEF2D MEF2D DNA-binding; Transcription factor Q14814 4209 1q22 human S180-p 449933 LTDPRLLsPQQPALQ transcription, induced 26660426 3 44 11 IEG genes during preBCR signaling +ATRIP ATRIP Cell cycle regulation; DNA repair, damage; DNA-binding Q8WXE1 84126 3p21.31 human S68-p 454388 EELDTLAsQALSQCP intracellular localization 15451423 1 0 0 +CAMK4 CAMK4 EC 2.7.11.17; KINASE; Kinase, protein; Protein kinase, CAMK; Protein kinase, Ser/Thr (non-receptor) Q16566 814 5q22.1 human S189-gl 7780008 KIADFGLsKIVEHQV Pkinase enzymatic activity, inhibited 19506079 1 1 0 reduced GlcNAcylation levels by 70% +Wnk4 WNK4 EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, Other; Protein kinase, Ser/Thr (non-receptor) Q80UE6 69847 11|11 D mouse K990-ub 40323311 APISEEGkPQLVGRF protein degradation 23576762 1 1 0 regulates electrolyte homeostasis and involved in Pseudohypoaldosteronism type II (PHAII) pathogenesis +Ahcyl2 AHCYL2 Amino Acid Metabolism - cysteine and methionine; EC 3.3.1.1; Hydrolase; Motility/polarity/chemotaxis; Other Amino Acids Metabolism - selenoamino acid Q68FL4 74340 6|6 A3.3 mouse S154-p 7172001 SRSISQSsTDSYSSA molecular association, regulation SLC4A4(INDUCES) 27382360 2 0 1 S149 and T172 are also involved in activation of SLCA4 +ARHGDIA RhoGDI alpha Apoptosis; Cell adhesion; Cell development/differentiation; G protein regulator, misc.; Motility/polarity/chemotaxis P52565 396 17q25.3 human K178-ac 3669184 ARGSYSIkSRFTDDD Rho_GDI molecular association, regulation cytoskeletal reorganization RHOA(DISRUPTS) 26719334 1 5 3 affects actin filament formation +Foxo3 FOXO3A Autophagy; DNA-binding; Oncoprotein; Transcription factor Q9WVH4 56484 10 B2|10 22.79 cM mouse S412-p 12084437 GLMQRGSsFPYTAKS apoptosis, inhibited; signaling pathway regulation 19942091 5 7 2 Akt-AMPK-Foxo3 signaling +KCNK18 KCNK18 Channel, ligand-gated; Channel, potassium; Membrane protein, integral; Membrane protein, multi-pass Q7Z418 338567 10q25.3 human S252-p 2712200 QAMERSNsCPELVLG intracellular localization; activity, inhibited transcription, inhibited 25202008; 30327410 8 0 1 +Ccnd1 CCND1 Activator; Cell cycle regulation; Nuclear receptor co-regulator; Oncoprotein P25322 12443 7 F5|7 88.92 cM mouse T286-p 447839 EEAGLACtPTDVRDV activity, induced; protein degradation; protein stabilization; molecular association, regulation; ubiquitination; intracellular localization cell cycle regulation; carcinogenesis, inhibited PIN1(INDUCES) 11124803; 11805292; 15735756; 17130121; 18606783; 35210557; 9136925; 9832503 35 5 1 +FUS hnRNP P2 DNA-binding; Nuclear receptor co-regulator; Oncoprotein; RNA splicing; RNA-binding; SUMO LIGASE P35637 2521 16p11.2 human S439-p 56654253 TCENMNFsWRNECNQ zf-RanBP molecular association, regulation translation, inhibited RNA(DISRUPTS) 35777956 1 2 0 +NOTCH1 Notch 1 Membrane protein, integral; Motility/polarity/chemotaxis; Oncoprotein; Receptor, misc.; Transcription factor P46531 4851 9q34.3 human S2523-p 467289 SPDQWSSsSPHSNVS protein degradation; receptor inactivation, altered 16880534 1 0 0 Alanine mutation of 4 serines (S2522/S2523/S2524/S2525) causes increased protein stability. +SMURF2 SMURF2 EC 6.3.2.-; EC 6.3.2.19; Ligase; UBIQUITIN LIGASE; Ubiquitin conjugating system; Ubiquitin ligase Q9HAU4 64750 17q23.3-q24.1 human R239-m2 56854402 RVRSQRHrNYMSRTH protein degradation 26126536 1 0 0 +PXN PXN iso2 Adaptor/scaffold; Cell adhesion; Cytoskeletal; Motility/polarity/chemotaxis P49023-2 5829 12q24.23 human Y88-p 448909 PQSSSPVyGSSAKTS Paxillin phosphorylation cell motility, altered; signaling pathway regulation; cell growth, altered 20133777 6 48 1343 Y88A mutation decreases PDGF-AA-induced phosphorylation of Akt T308 and Y473, p130CAS Y165 and SHP2 Y542 +Cacnb2 CACNB2 Channel, calcium Q8VGC3 116600 17q12.3 rat S625-p 469619 KQRSRHKsKDRYCDK intracellular localization 15311280 2 0 0 +GNAZ G-alpha(z) Endoplasmic reticulum; G protein, heterotrimeric; G protein, heterotrimeric alpha G((i/o/t/z)); Nuclear envelope P19086 2781 22q11.22-q11.23 human S16-p 451242 EKEAARRsRRIDRHL G-alpha activity, induced; protein conformation 9166747 3 0 2 +SLITRK1 SLITRK1 Cell development/differentiation; Membrane protein, integral Q96PX8 114798 13q31.1 human S695-p 4749248 DCGSHSLsD______ molecular association, regulation cell growth, altered 14-3-3 beta(INDUCES) 19640509 1 4 0 +NHERF2 NHERF-2 Adaptor/scaffold Q15599 9351 16p13.3 human T305-p 31858574 SGLHLSPtAAEAKEK EBP50_C molecular association, regulation signaling pathway regulation Ezrin(DISRUPTS) 26251448 1 1 0 +CCKBR CCKBR GPCR, family 1; Membrane protein, integral; Membrane protein, multi-pass; Receptor, GPCR P32239 887 11p15.4 human S437-p 17825901 IASLSRLsYTTISTL molecular association, regulation ARRB1(INDUCES) 21156802 1 0 0 +MACF1 ACF7 Actin-binding; Cytoskeletal; Motility/polarity/chemotaxis Q9UPN3 23499 1p34.3 human S7314-p 15427027 KSASRPGsRAGSRAG intracellular localization cell motility, induced; cytoskeletal reorganization 21295697 1 3 0 inhibits localization along microtubules, alters organization of microtubules, regulates skin wound repair, SC migration +LCP2 SLP76 Adaptor/scaffold Q13094 3937 5q35.1 human K266-sm 1878271702 KKPPFSDkPSIPAGR transcription, induced 31666306 1 1 0 enhances NFAT-driven IL-2 transcription +PRKCA PKCA EC 2.7.11.13; KINASE; Kinase, protein; Oncoprotein; Protein kinase, AGC; Protein kinase, Ser/Thr (non-receptor) P04409 282001 cow S657-p 448597 QSDFEGFsYVNPQFV Pkinase_C activity, induced; protein stabilization; protein conformation; phosphorylation; enzymatic activity, induced 8856079; 9013603; 9363767 28 4 2 +AR AR DNA-binding; Nuclear receptor; Transcription factor P10275 367 Xq12 human K610-ac 1877421608 TIDKFRRkNCPSCRL zf-C4 molecular association, regulation; intracellular localization carcinogenesis, induced; cell growth, induced; transcription, induced Ack(INDUCES) DNA(INDUCES) 35704598 1 1 0 +AGO2 AGO2 EC 3.1.26.n2; RNA processing; RNA-binding Q9UKV8 27161 8q24.3 human S672-p 1873647700 IFYRDGVsEGQFQQV Piwi molecular association, regulation DNA repair, induced DNA(INDUCES) 34039517 1 1 0 +Creb1 CREB DNA-binding; Transcription factor Q01147 12912 1 C2|1 32.74 cM mouse S128-p 448547 RKILNDLsSDAPGVP pKID activity, induced neural plasticity; transcription, induced; transcription, altered 11970866; 34607805 11 20 2 +MORC3 MORC3 Cell cycle regulation; RNA-binding Q14149 23515 21q22.12 human K740-sm 14988620 EMNDKYVkKETCHQS molecular association, regulation PML(INDUCES) 20501696 1 2 0 +MCL1 MCL1 Apoptosis; Channel, misc.; Inhibitor; Membrane protein, integral; Mitochondrial Q07820 4170 1q21.2 human K308-ub 10837363 TKRDWLVkQRGWDGF Bcl-2 protein degradation 28522751 1 3 7 +Pak1 PAK1 EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, STE; Protein kinase, Ser/Thr (non-receptor) O88643 18479 7 E1|7 53.57 cM mouse T212-p 448176 VIEPLPVtPTRDVAT molecular association, regulation; intracellular localization; enzymatic activity, induced neural plasticity; cell growth, induced; cell motility, altered; cytoskeletal reorganization 11604394; 12176333; 12176334; 27583434; 36135748 17 27 19 +Prkcb PKCB iso2 EC 2.7.11.13; KINASE; Kinase, protein; Motility/polarity/chemotaxis; Protein kinase, AGC; Protein kinase, Ser/Thr (non-receptor) P68403-2 25023 1q36 rat T500-p 447896 WDGVTTKtFCGTPDY Pkinase enzymatic activity, induced 7961692 10 47 44 +MAPT Tau iso8 ACETYLTRANSFERASE; Acetyltransferase; Cytoskeletal P10636-8 4137 17q21.31 human T403-p 449131 SPVVSGDtSPRHLSN molecular association, regulation Tau iso8(INDUCES) 15190058 6 30 26 polymerized into filaments when 4?6 mol of phosphate per mol of tau were incorporated +PRKAA1 AMPKA1 Autophagy; EC 2.7.11.1; EC 2.7.11.26; EC 2.7.11.27; EC 2.7.11.31; KINASE; Kinase, protein; Protein kinase, CAMK; Protein kinase, Ser/Thr (non-receptor) Q13131 5562 5p13.1 human S494-p 4717473 GTATPQRsGSVSNYR AdenylateSensor phosphorylation 23623684 3 2 15 enhances T479 phosphorylation and T172 dephosphorylation +SETMAR SETMAR Amino Acid Metabolism - lysine degradation; EC 2.1.1.43; METHYLTRANSFERASE; Methyltransferase; Methyltransferase, protein lysine Q53H47 6419 3p26.1 human S508-p 10940417 LYDNRRRsAQWLDQE Transposase_1 protein stabilization; molecular association, regulation; activity, inhibited DNA repair, induced; chromatin organization, altered H3(INDUCES) 22231448; 25024738 2 18 2 Chk1 half-life increased; repression of replication fork restart, induce chromatin association in IR and its reversed in HU +Mapt Tau ACETYLTRANSFERASE; Acetyltransferase; Cytoskeletal P19332 29477 10q32.1 rat S513-p 447928 SGYSSPGsPGTPGSR molecular association, regulation; protein conformation neural plasticity PPP1CC(INDUCES) 28784767; 33519375; 36859689 175 57 116 +Shc1 SHC1 Adaptor/scaffold; Apoptosis; Mitochondrial; Motility/polarity/chemotaxis P98083 20416 3 F1|3 39.11 cM mouse Y423-p 448511 ELFDDPSyVNIQNLD activity, induced; molecular association, regulation; phosphorylation cell differentiation, altered; apoptosis, induced; cell growth, induced GRB2(INDUCES); SHIP(INDUCES) 11713219; 12101399; 14576154; 15930121; 20697350; 24837366; 9083021 42 91 1971 Shc3F breast tumor growth was significantly delayed, and display a significant increase in VEGF protein; in vitro and in vivo +NKD2 NKD2 Cell development/differentiation; Ubiquitin conjugating system Q969F2 85409 5p15.33 human S31-p 23254812 FVASAYAsGRKGAEE molecular association, regulation; intracellular localization signaling pathway regulation NKD2(INDUCES) 34433025 1 1 4 regulates ORAI1 localization and Ca2+-NFAT pathway +FANCD2 FANCD2 DNA repair, damage Q9BXW9 2177 3p25.3 human S898-p 1871613602 SECDPTPsHRGQLNK FancD2 molecular association, regulation; ubiquitination; intracellular localization; activity, inhibited cell cycle regulation; DNA repair, inhibited; signaling pathway regulation DNA(DISRUPTS) 31167143 1 1 0 inhibits Fanconi anemia pathway leading to inhibition of DNA repair; 882-898 cluster +HGS Hrs Adaptor/scaffold; Motility/polarity/chemotaxis O14964 9146 17q25.3 human Y334-p 450192 ARYLNRNyWEKKQEE intracellular localization; receptor recycling, altered; phosphorylation 12953068; 17101784 2 16 261 Hrs phosphorylation mutant Y329,334F is unable to degrade ubiquinated EGFR. ; Cbl expression alters Hrs phosphorylation and fractionation in membrane and cyosokic fractions. +CFTR CFTR Channel, chloride; EC 3.6.3.49; Hydrolase; Membrane protein, integral; Membrane protein, multi-pass; Transporter; Transporter, ABC family P13569 1080 7q31.2 human S707-p 2907509 SILNPINsIRKFSIV CFTR_R activity, induced 12588899 2 0 0 +Sh2b2 APS Adaptor/scaffold Q9Z200 114203 12q12 rat S588-p 456846 SARSRSNsTEHLLEA intracellular localization 16141217 1 2 0 +CMKLR1 CMKLR1 GPCR, family 1; Membrane protein, integral; Membrane protein, multi-pass; Receptor, GPCR Q99788 1240 12q23.3 human T255-p 32668900 QRNRLAKtKKPFKII 7tm_1 receptor internalization, induced 24658352 1 0 0 +PKP1 plakophilin 1 Cell adhesion; Motility/polarity/chemotaxis Q13835 5317 1q32.1 human T179-p 27717307 LGSKGQKtTQNRYSF activity, induced; protein stabilization cell motility, induced; cell growth, induced; translation, induced; cell adhesion, inhibited 23444369 1 1 0 +PAG1 PAG Adaptor/scaffold; Membrane protein, integral Q9NWQ8 55824 8q21.13 human Y317-p 450659 EEEISAMySSVNKPG PAG molecular association, regulation carcinogenesis, induced; cell growth, induced; apoptosis, inhibited LYN(INDUCES); CSK(INDUCES) 10790433; 17389760; 18070987; 25897081 9 31 643 +Npas4 NPAS4 DNA-binding Q8BGD7 225872 19|19 A mouse T427-p 1869686800 LVCTPPYtPHQPGGC molecular association, regulation neural plasticity; transcription, induced CBP(INDUCES) 31801086 1 1 0 +Hdac9 HDAC9 DEACETYLASE; Deacetylase; EC 3.5.1.98; Transcription, coactivator/corepressor Q99N13 79221 12|12 A3 mouse S240-p 4772328 KVAERRSsPLLRRKD intracellular localization 15546868 1 17 1 decreased nuclear localization +Nkx2-5 NKX2-5 DNA-binding P42582 18091 17 A3.3|17 13.6 cM mouse S163-p 465563 FKQQRYLsAPERDQL Homeodomain transcription, altered 9858576 1 0 1 +BRCA1 BRCA1 EC 6.3.2.-; Nuclear receptor co-regulator; Transcription, coactivator/corepressor; Tumor suppressor; UBIQUITIN LIGASE; Ubiquitin conjugating system; Ubiquitin ligase P38398 672 17q21.31 human S308-p 451604 KAEFCNKsKQPGLAR cell cycle regulation 26831064 2 0 0 mitotic microtubule assembly +Arrb2 ARRB2 Adaptor/scaffold Q91YI4 216869 11 B3|11 42.99 cM mouse K207-ub 6140808 HLEASLDkELYYHGE Arrestin_C molecular association, regulation mAChR M2(INDUCES); mAChR m1(INDUCES) 19055777 1 0 0 +PDPK1 PDK1 EC 2.7.11.1; KINASE; Kinase, protein; Nuclear receptor co-regulator; Protein kinase, AGC; Protein kinase, Ser/Thr (non-receptor) O15530 5170 16p13.3 human Y376-p 447695 DEDCYGNyDNLLSQF enzymatic activity, induced apoptosis, altered 11481331; 20044479; 20643654 8 1 0 +ASIC1 ASIC1 Channel, cation; Membrane protein, integral; Membrane protein, multi-pass; Transporter; Transporter, ion channel P78348 41 12q13.12 human S25-p 25554906 IQAFASSsTLHGLAH ASC activity, induced; intracellular localization signaling pathway regulation 22553040 1 0 0 increase the surface expression, pain hypersensitivity/ regulates BDNF-mediated mechanical hyperalgesia PI3K/Akt signaling pathway +Dpysl2 CRMP-2 Microtubule-binding; Motility/polarity/chemotaxis O08553 12934 14 D1|14 34.6 cM mouse T555-p 448084 DNIPRRTtQRIVAPP protein processing cell growth, inhibited; cytoskeletal reorganization; signaling pathway regulation; cell growth, altered 19735446; 20961402; 32860158 19 2 8 inhibits dendritic growth +Ppp1r1b DARPP-32 Motility/polarity/chemotaxis; Protein phosphatase, regulatory subunit Q6J4I0 360616 10q31 rat S137-p 448046 EEDEEEDsQAEVLKG DARPP-32 phosphorylation cell motility, induced; signaling pathway regulation 21564097; 7708705 13 4 15 Dephosphorylation of S137 by PPP3CAis inhibited. ; induces locomotion through the DARPP-32/PP1 signaling pathway +Prkcb PKCB EC 2.7.11.13; KINASE; Kinase, protein; Motility/polarity/chemotaxis; Protein kinase, AGC; Protein kinase, Ser/Thr (non-receptor) P68403 25023 1q36 rat T500-p 447896 WDGVTTKtFCGTPDY Pkinase enzymatic activity, induced 21215369 10 47 44 +DNM1L DRP1 Apoptosis; EC 3.6.5.5; Endoplasmic reticulum; Hydrolase; Microtubule-binding; Mitochondrial; Motor O00429 10059 12p11.21 human S637-p 483971 VPVARKLsAREQRDC activity, induced; molecular association, regulation; intracellular localization; enzymatic activity, inhibited; activity, inhibited; protein conformation cell cycle regulation; carcinogenesis, induced; carcinogenesis, inhibited; cell motility, induced; cell growth, inhibited; signaling pathway regulation; autophagy, induced; cell growth, induced; cell differentiation, induced; apoptosis, inhibited; cytoskeletal reorganization; autophagy, inhibited DRP1(NOT_REPORTED) 17553808; 18838687; 21646527; 25595902; 27540013; 28436948; 30091204; 31494243; 31992853; 32433544; 33802063; 33805672; 34038722; 34589283; 34963686; 35100966; 35297042; 35697672; 35739087; 35887094; 36162640; 36385754; 37024453; 37442283 103 3 0 +TFEB TFEB DNA-binding; Transcription factor P19484 7942 6p21.1 human S109-p 3181610 NKFAAHIsPAQGSPK MITF_TFEB_C_3_N activity, induced; intracellular localization transcription, inhibited; cell growth, altered 29945972 1 26 0 +CDC42EP4 CDC42EP4 Cytoskeletal Q9H3Q1 23580 17q25.1 human S80-p 35524901 SSKRSLLsRKFRGSK PBD molecular association, regulation cell motility, induced; cytoskeletal reorganization CDC42(DISRUPTS); ARHGEF17(INDUCES); PARD6G(INDUCES) 25086031 1 2 0 ARHGEF-phosphoCEP4 interaction activates Rac, activated Rac increased filopodium formation +BTK Btk EC 2.7.10.2; KINASE; Kinase, protein; Protein kinase, TK; Protein kinase, tyrosine (non-receptor) Q06187 695 Xq22.1 human S51-p 28710300 FERGRRGsKKGSIDV PH protein degradation; molecular association, regulation; ubiquitination; intracellular localization; phosphorylation signaling pathway regulation 14-3-3 zeta(INDUCES) 23754751 1 0 0 induces tyrosine phosphorylation and BCR signaling +STXBP5L STXBP5L Q9Y2K9 9515 3q13.33 human S800-p 34668139 SAACMEIsLPVTTEE protein degradation 25002582 1 1 0 ; in a multiple residue S->D mutant +ALK ALK EC 2.7.10.1; KINASE; Kinase, protein; Membrane protein, integral; Oncoprotein; Protein kinase, TK; Protein kinase, tyrosine (receptor) Q9UM73 238 2p23.2-p23.1 human Y1507-p 450379 TSLWNPTyGSWFTEK molecular association, regulation SHC1(NOT_REPORTED); IRS2(INDUCES); SHC3(INDUCES); SHC1(INDUCES) 17274988; 30459283 2 9 91 +PARP1 PARP1 DNA repair, damage; EC 2.4.2.30; Nuclear envelope; Nuclear receptor co-regulator; Nucleolus; Transferase P09874 142 1q42.12 human K508-m1 12261103 AALSKKSkGQVKEEG ADP-ribosylation; molecular association, regulation; enzymatic activity, induced DNA(INDUCES) 24088713 1 1 8 regulates ARTD1 recruitment to damaged chromation in DNA-damage dependent manner +ZC3HC1 NIPA Cell cycle regulation; Ubiquitin conjugating system Q86WB0 51530 7q32.2 human S395-p 478573 PGLEVPSsPLRKAKR molecular association, regulation; activity, inhibited cell cycle regulation SKP1A(DISRUPTS) 17389604; 27226629 3 54 24 +PIK3AP1 BCAP Adaptor/scaffold Q9DDT2 374268 chicken Y448-p 448184 PGSDEELyESMAGFV molecular association, regulation PIK3R1(INDUCES) 11163197 2 0 0 +Arpc1a ARPC1A Cytoskeletal; Motility/polarity/chemotaxis Q99PD4 81824 12p11 rat T21-p 283458503 HAWNRDRtQIALSPN molecular association, regulation cytoskeletal reorganization N-WASP(INDUCES) 28972183 1 0 0 +FLOT1 FLOT1 Adaptor/scaffold O75955 10211 6p21.33 human K51-ub 12322225 NTLTLNVkSEKVYTR Band_7 protein stabilization; intracellular localization carcinogenesis, induced Snail1(INDUCES) 30631151 1 0 1 translocation of Flot-1 to the nucleus, suppresses proteasomal degradation, promotes epithelial-to-mesenchymal transition (EMT) high metastatic potential +E2F1 E2F1 DNA-binding; Transcription factor Q01094 1869 20q11.22 human K164-ub 95155307 AEVLKVQkRRIYDIT E2F_TDP protein stabilization DNA repair, induced; cell growth, induced; transcription, induced DNA(INDUCES) 28542143 1 0 0 +PDP1 PDP1 EC 3.1.3.43; Mitochondrial; Motility/polarity/chemotaxis; PHOSPHATASE; Protein phosphatase, Ser/Thr (non-receptor) Q9P0J1 54704 8q22.1 human Y94-p 15422109 SILKANEySFKVPEF enzymatic activity, inhibited 24962578 2 1 0 +Gphn gephyrin Adaptor/scaffold; EC 2.10.1.1; EC 2.7.7.75 Q03555 64845 6q24 rat S337-p 481401 NILRASHsAVDITKV neural plasticity 25535349 1 31 5 promoted activity dependent inhibitory synapse formation and cluster size regulation +NR1H2 LXR-beta Nuclear receptor P55055 7376 19q13.33 human S431-p 1881579402 LVSLRTLsSVHSEQV carcinogenesis, induced; cell motility, induced; cell growth, induced; transcription, altered 37059993 1 0 0 +Snai1 Snail1 C2H2-type zinc finger protein; Transcription factor Q02085 20613 2 H3|2 87.33 cM mouse K98-ub 1872271900 LSDEDSGkSSQPPSP protein stabilization; molecular association, regulation carcinogenesis, inhibited; transcription, inhibited GSK3B(INDUCES) 16096638 2 0 0 induces EMT +IRS1 IRS1 Adaptor/scaffold; Motility/polarity/chemotaxis P35568 3667 2q36.3 human Y632-p 447565 GRKGSGDyMPMSPKS molecular association, regulation cell differentiation, induced; transcription, induced PIK3R1(INDUCES) 11416002; 12525499 12 13 288 +YAP1 YAP1 Oncoprotein; Transcription, coactivator/corepressor P46937 10413 11q22.1 human S61-p 484116 IVHVRGDsETDLEAL intracellular localization; activity, inhibited cell growth, induced; cell growth, inhibited; apoptosis, induced; cell motility, altered; cytoskeletal reorganization; transcription, inhibited 24658687; 25180175; 25751139; 28416665 13 47 1 sensitivity to gemcitabine +PIAS1 PIAS1 EC 6.3.2.-; Nuclear receptor co-regulator; SUMO LIGASE; SUMO conjugating system; SUMO ligase; Transcription, coactivator/corepressor O75925 8554 15q23 human S13-p 53747702 ELKQMVMsLRVSELQ protein degradation translation, inhibited 26157031 1 0 0 +SSH1 SSH1 EC 3.1.3.16; EC 3.1.3.48; PHOSPHATASE; Protein phosphatase, dual-specificity Q8WYL5 54434 12q24.11 human S834-p 10793641 KELERLKsVPADPAP molecular association, regulation; enzymatic activity, inhibited 14-3-3 beta(INDUCES) 21857021 1 5 1 +Tigit TIGIT Cell surface; Membrane protein, integral P86176 100043314 16|16 B4 mouse Y230-p 27266400 DYADPQEyFNVLSYR molecular association, regulation SHIP(INDUCES); ARRB2(INDUCES) 24817116 2 0 0 NF-kB activation is inhibited, IFN-gamma production inhibited +DNM1L DRP1 iso3 Apoptosis; EC 3.6.5.5; Endoplasmic reticulum; Hydrolase; Microtubule-binding; Mitochondrial; Motor O00429-3 10059 12p11.21 human S611-p 483971 VPVARKLsAREQRDC molecular association, regulation SMCR7(DISRUPTS) 29899447 103 3 0 phosphomimetic mutant S611D failed to bind to SMCR7 (aka MID49). +Scn2a SCN2A Channel, sodium; Membrane protein, integral; Membrane protein, multi-pass P04775 24766 3q21 rat S1124-p 6003506 LNTEEFSsESDMEES Na_trans_assoc intracellular localization 19064667 1 0 0 regulates SCN2A accumulation at the axonal initial segment (AIS) and interaction with ankyrin G +CALCA CALCA Secreted; Secreted, signal peptide P01258 796 11p15.2 human T97-p 1871177713 TCMLGTYtQDFNKFH Calc_CGRP_IAPP protein conformation 33220304 0 1 0 inhibits fibril formation and growth +Cebpb C/EBP-beta DNA-binding; Motility/polarity/chemotaxis; Transcription factor P21272 24253 3q42 rat K216-ac 458939 APAKAKAkKAVDKLS transcription, inhibited 24344329 4 0 0 +NTRK1 TrkA iso2 EC 2.7.10.1; KINASE; Kinase, protein; Membrane protein, integral; Oncoprotein; Protein kinase, TK; Protein kinase, tyrosine (receptor) P04629-2 4914 1q23.1 human Y490-p 447762 HIIENPQyFSDACVH activity, induced; intracellular localization; enzymatic activity, induced; phosphorylation cell differentiation, induced 27655914; 29229648; 9099755 23 0 2 neurite outgrowth and differentiation +PTK2 FAK EC 2.7.10.2; KINASE; Kinase, protein; Protein kinase, TK; Protein kinase, tyrosine (non-receptor) Q05397 5747 8q24.3 human Y925-p 447966 DRSNDKVyENVTGLV Focal_AT protein stabilization; molecular association, regulation; intracellular localization; activity, inhibited; enzymatic activity, induced; phosphorylation carcinogenesis, induced; cell motility, induced; cell adhesion, induced; signaling pathway regulation; transcription, altered; cell differentiation, altered; cell growth, induced; chromatin organization, altered; apoptosis, inhibited; cell motility, altered; cell adhesion, altered; cytoskeletal reorganization PXN(DISRUPTS); GRB2(INDUCES) 10821872; 11839732; 12754219; 15735019; 18032789; 18437915; 21289086; 21852560; 27226554; 29954829; 32107290; 33761359; 35682554; 35982848; 7597091 104 17 427 +YY2 YY2 C2H2-type zinc finger protein O15391 404281 Xp22.12 human K247-m1 1873286916 KVKPKRSkGEPPKTV molecular association, regulation cell cycle regulation; carcinogenesis, induced; cell growth, induced; transcription, altered DNA(INDUCES) 29098080 1 1 0 mutant K247R tumors were in general heavier and larger than YY2 WT; 1/3 genes positively regulated by SETD7 and negatively regulated by LSD1; regulated binding af?nity with endogenous genomic loci +Stat4 STAT4 DNA-binding; Transcription factor P42228 20849 1 C1.1|1 26.67 cM mouse Y694-p 447790 TERGDKGyVPSVFIP activity, induced; molecular association, regulation; intracellular localization; activity, inhibited; phosphorylation cell differentiation, altered; transcription, altered; cell growth, altered FHL1 iso1(INDUCES) DNA(INDUCES) 10961885; 12213961; 15963787 10 5 8 phosphorylation of STAT4 S722 +ANXA2 ANXA2 Calcium-binding; Lipid-binding; Motility/polarity/chemotaxis P07355 302 15q22.2 human Y24-p 449483 HSTPPSAyGSVKAYT molecular association, regulation; intracellular localization; phosphorylation carcinogenesis, induced; cell growth, induced; cell motility, induced; transcription, induced; signaling pathway regulation Myc(INDUCES); EGFR(INDUCES); STAT3(INDUCES) 15302870; 18990701; 23555942; 25136068; 26272794; 26307676; 26716413; 28130864; 28470457; 30081903; 30738042; 31113450; 32615410; 33941853; 34502195; 36229838 29 64 2613 induces ERK1/2 signaling +Zfp24 ZNF24 C2H2-type zinc finger protein; DNA-binding; Transcription factor Q91VN1 59057 18|18 A2 mouse T302-p 1244446 VQHQRVHtGEKPYKC molecular association, regulation cell differentiation, inhibited; transcription, inhibited DNA(DISRUPTS) 29786073; 29791837 2 5 6 regulates oligodendrocyte differentiation and CNS myelination; mediates the expression of Sox10 and Myrf; oligodendrocyte differentiation and myelination +CNN3 calponin 3 Cytoskeletal; Motility/polarity/chemotaxis Q15417 1266 1p21.3 human S296-p 4776198 GTNGSEIsDSDYQAE molecular association, regulation cytoskeletal reorganization 20861310 2 4 9 stimulates dissociation of calponin 3 from actin cytoskeleton (F-actin) +NTRK1 TrkA iso2 EC 2.7.10.1; KINASE; Kinase, protein; Membrane protein, integral; Oncoprotein; Protein kinase, TK; Protein kinase, tyrosine (receptor) P04629-2 4914 1q23.1 human Y674-p 447763 RDIYSTDyYRVGGRT PK_Tyr_Ser-Thr activity, induced; intracellular localization; enzymatic activity, induced; phosphorylation cell differentiation, induced 27655914; 29229648; 9099755 14 3 10 neurite outgrowth and differentiation +Ctnnb1 CTNNB1 Actin-binding; Cell adhesion; Motility/polarity/chemotaxis; Nuclear receptor co-regulator; Oncoprotein; Transcription factor Q02248 12387 9 F4|9 72.19 cM mouse S191-p 467710 SRHAIMRsPQMVSAI intracellular localization 18423204 5 45 11 +XRCC1 XRCC1 DNA repair, damage P18887 7515 19q13.31 human S416-p 3181468 SSEEDEAsHSGGSGD molecular association, regulation PARP1(DISRUPTS) 25477519 1 4 0 +ATF2 ATF-2 ACETYLTRANSFERASE; C2H2-type zinc finger protein; EC 2.3.1.48; Transcription factor P15336 1386 2q31.1 human K357-ac 1910100 DPDEKRRkFLERNRA bZIP_1 cell growth, inhibited; cell motility, inhibited; transcription, induced; transcription, altered 17590016; 33178766 2 1 0 +Il22ra1 IL22RA1 Membrane protein, integral Q80XZ4 230828 4 D3|4 67.99 cM mouse S414-p 33373903 VEDSGKDsTPGILST protein stabilization 24742671 1 0 0 +CTDSPL2 CTDSPL2 EC 3.1.3.-; Motility/polarity/chemotaxis; PHOSPHATASE; Phosphatase Q05D32 51496 15q15.3-q21.1 human T86-p 469354 DNNLITStPRAGEKP cell cycle regulation; carcinogenesis, induced; cell motility, induced; cell growth, induced; transcription, inhibited 34813892 1 17 38 +Tsc2 TSC2 Cell cycle regulation; GAP; GAP, misc.; Nuclear receptor co-regulator; Tumor suppressor Q61037 22084 17 A3.3|17 12.41 cM mouse S1388-p 450212 QPLSKSSsSPELQTL phosphorylation transcription, altered; signaling pathway regulation; translation, inhibited 32912901 19 14 6 inhibits S6 and ULK1 phosphorylation through inhibiting mTORC1 signaling +H3c1 H3 DNA-binding P68433 360198 13|13 A3.1 mouse K56-ac 3804954 REIRRYQkSTELLIR Histone acetylation cell differentiation, inhibited; endocytosis, altered; cell adhesion, altered; transcription, induced 20404188; 32265492; 33195484 33 14 2 SIRT6 inhibits acetylated H3 and AKT signaling ; axon guidance; Histone acetylation induces AKT signaling at AKT promoter +PITX1 PITX1 Cell development/differentiation; DNA-binding; Transcription factor P78337 5307 5q31.1 human Y175-p 54204602 VQPYEDVyAAGYSYN protein degradation; protein stabilization transcription, inhibited 26840794; 27752061 2 0 0 +STAT3 STAT3 DNA-binding; Motility/polarity/chemotaxis; Nuclear receptor co-regulator; Transcription factor P40763 6774 17q21.2 human K163-me 1881268801 QDLEQKMkVVENLQD activity, induced signaling pathway regulation 33742125 1 1 0 partially inhibits angiogenic function of STAT3 in vitro and in vivo +CSNK1A1 CK1A EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, CK1; Protein kinase, Ser/Thr (non-receptor) P48729 1452 5q32 human K65-ub 15490106 LYESKLYkILQGGVG Pkinase protein degradation 26909574 1 5 2 +CTBP1 CTBP1 Cell cycle regulation; EC 1.1.1.-; Nuclear receptor co-regulator; Oxidoreductase; Transcription, coactivator/corepressor Q13363 1487 4p16.3 human S422-p 455350 AHPPHAPsPGQTVKP protein degradation apoptosis, induced 14567915; 15708980; 16984892 3 2 0 in H1299 cells lacking p53 +Brsk1 BRSK1 EC 2.7.11.1; EC 2.7.11.26; KINASE; Kinase, protein; Protein kinase, CAMK; Protein kinase, Ser/Thr (non-receptor) Q5RJI5 381979 7|7 A1 mouse T189-p 456027 VGDSLLEtSCGSPHY Pkinase intracellular localization; enzymatic activity, induced cytoskeletal reorganization BRSK1(INDUCES) 17482548; 29698519 8 1 0 activation of Sad kinases in the axon during development; Sad kinases are required for the survival of cortical neurons; LKB1 phosphorylates Brsk1 and Brsk2. +KIF2B KIF2B Microtubule-binding; Motor Q8N4N8 84643 17q22 human T125-p 25247520 MIPQKNQtASGDSLD cell cycle regulation; cytoskeletal reorganization 22535524 1 1 0 involved in the corrections of k-MT attachment errors in early mitosis, microtubule depolymerization activity +Csk CSK EC 2.7.10.2; KINASE; Kinase, protein; Protein kinase, TK; Protein kinase, tyrosine (non-receptor) P41241 12988 9 B|9 31.18 cM mouse Y18-p 41510404 GTECIAKyNFHGTAE SH3_1 protein degradation; ubiquitination; phosphorylation; enzymatic activity, induced carcinogenesis, induced 36376335 1 1 1 regulates LCK phosphorylation and activity +Syk Syk EC 2.7.10.2; KINASE; Kinase, protein; Protein kinase, TK; Protein kinase, tyrosine (non-receptor) Q64725 25155 17p14 rat Y625-p 459327 LRLRNYYyDVVN___ molecular association, regulation; phosphorylation; enzymatic activity, induced FCER1G(INDUCES) 20554527 3 2 2 mutation of this site stimulates phosphorylation of Y317, Y519 and Y520; required for activation of ERK1/2 and p38MAP kinases; required for activation of NFAT and NFkB +NQO1 NQO1 EC 1.6.5.2; Oxidoreductase P15559 1728 16q22.1 human S82-p 13910234 AYKEGHLsPDIVAEQ Flavodoxin_2 protein degradation; protein stabilization; molecular association, regulation; enzymatic activity, inhibited; protein conformation p73(DISRUPTS) Other(DISRUPTS) 30243998; 34817874; 36096178 3 14 0 +EPHA2 EphA2 EC 2.7.10.1; KINASE; Kinase, protein; Membrane protein, integral; Protein kinase, TK; Protein kinase, tyrosine (receptor) P29317 1969 1p36.13 human Y921-p 457515 ESIKMQQyTEHFMAA SAM_1 molecular association, regulation GRB2(INDUCES); SHIP-2(INDUCES) 24825902 1 7 24 +ITGB7 ITGB7 Cell adhesion; Membrane protein, integral; Motility/polarity/chemotaxis; Receptor, misc. P26010 3695 12q13.13 human Y753-p 469601 YRLSVEIyDRREYSR Integrin_b_cyt cell adhesion, altered 16874740 1 0 1 +BPTF FALZ DNA-binding; Transcription factor Q12830 2186 17q24.2 human K942-ub 52485010 KAVQMCSkPREFALA protein degradation 26676607 0 2 0 +CXCR4 CXCR4 GPCR, family 1; Membrane protein, integral; Membrane protein, multi-pass; Receptor, GPCR P61073 7852 2q22.1 human Y135-p 1869808401 AFISLDRyLAIVHAT 7tm_1 activity, induced carcinogenesis, induced; cell motility, induced 31562188 1 0 0 +PRKDC DNAPK DNA repair, damage; EC 2.7.11.1; KINASE; Kinase, protein; Nucleolus; Protein kinase, Ser/Thr (non-receptor); Protein kinase, atypical P78527 5591 8q11.21 human S2677-p 31875303 HTSPSSDsLLFAHKR DNAPKcs_CC5 DNA repair, inhibited 24687855 1 1 0 cell survival inhibited +NKX2-1 NKX2-1 Cell development/differentiation; DNA-binding; Transcription factor P43699 7080 14q13.3 human K151-ub 1877644900 GSLGDVSkNMAPLPS protein degradation; ubiquitination cell growth, inhibited; cell motility, inhibited 30849519 1 0 0 +CBS CBS Amino Acid Metabolism - cysteine and methionine; Amino Acid Metabolism - glycine, serine and threonine; EC 4.2.1.22; Lyase; Other Amino Acids Metabolism - selenoamino acid P35520 875 21q22.3 human S227-p 50301801 LDQYRNAsNPLAHYD PALP enzymatic activity, induced 26368121 2 0 0 +VAV1 VAV1 GEF; GEF, Rac/Rho; Motility/polarity/chemotaxis; Oncoprotein P15498 7409 19p13.3 human Y142-p 448809 SVGDEDIySGLSDQI molecular association, regulation cell motility, induced PLCG1(INDUCES); Lck(INDUCES); PIK3R1(INDUCES) 17050525; 29058761 6 2 0 neutrophil crawling behavior +Slc12a3 NCCT Membrane protein, integral; Membrane protein, multi-pass; Transporter; Transporter, SLC family P55018 54300 19p13-p12 rat S124-p 4709872 EDETGANsEKSPGEP activity, induced 22966159 1 2 0 +CCR7 CCR7 GPCR, family 1; Membrane protein, integral; Membrane protein, multi-pass; Motility/polarity/chemotaxis; Receptor, GPCR P32248 1236 17q21.2 human T375-p 455290 VEAETTTtFSP____ phosphorylation 15054093 1 0 0 ERK1/2 phosphorylation +Akt1 Akt1 EC 2.7.11.1; KINASE; Kinase, protein; Oncoprotein; Protein kinase, AGC; Protein kinase, Ser/Thr (non-receptor) P31750 11651 12 F1|12 61.2 cM mouse Y315-p 448519 TFCGTPEyLAPEVLE Pkinase enzymatic activity, induced apoptosis, altered 11445557; 20606012 5 2 13 +PARD3 PAR3-alpha Adaptor/scaffold; Motility/polarity/chemotaxis Q8TEW0 56288 10p11.22-p11.21 human S889-p 455653 LGLKKSSsLESLQTA molecular association, regulation 14-3-3 zeta(INDUCES) 15721295 4 1 0 +ARRB2 ARRB2 Adaptor/scaffold P32121 409 17p13.2 human S14-p 23083983 TRVFKKSsPNCKLTV receptor internalization, induced 26324936 2 1 1 +SPATA13 SPATA13 GEF; GEF, Rac/Rho Q96N96 221178 13q12.12 human S106-p 33670315 SDGGTEPsALVDDNG activity, induced cell motility, induced; cell adhesion, altered 24874604 1 1 0 Rac activation, regulates adhesion turnover, SPATA13 GEF activity promoted +Cebpb C/EBP-beta DNA-binding; Motility/polarity/chemotaxis; Transcription factor P28033 12608 2 H3|2 87.58 cM mouse T217-p 448447 AKAKAKKtVDKLSDE molecular association, regulation cell cycle regulation; apoptosis, inhibited; cell growth, altered CASP8(INDUCES); CASP1(INDUCES) 10635333; 11684016 4 0 0 +ATXN10 ataxin-10 Cell development/differentiation Q9UBB4 25814 22q13.31 human S12-p 14159379 RPPPARLsGVMVPAP molecular association, regulation; intracellular localization PLK1(INDUCES) 25666058 1 16 0 associates with midbody, +BID BID Apoptosis; Mitochondrial P55957 637 22q11.21 human S64-p 1880042000 LQTDGNRsSHSRLGR cell differentiation, induced; apoptosis, inhibited 36202990 1 0 0 +CTNNB1 CTNNB1 Actin-binding; Cell adhesion; Motility/polarity/chemotaxis; Nuclear receptor co-regulator; Oncoprotein; Transcription factor P35222 1499 3p22.1 human T332-p 29614600 VNIMRTYtYEKLLWT apoptosis, induced; transcription, inhibited 24117889 1 0 0 +ADRB2 ADRB2 GPCR, family 1; Membrane protein, integral; Membrane protein, multi-pass; Receptor, GPCR P07550 154 5q32 human Y219-p 4047200 LVIMVFVySRVFQEA 7tm_1; TM activity, induced; receptor internalization, induced; molecular association, regulation; intracellular localization; phosphorylation ARRB1(INDUCES) 17925438; 30131371 2 0 0 regulates localization of B-Arrestin2, induces activation of ERK2, induces phosphorylation at S355 and S356 +RAB7A Rab7 G protein; G protein, monomeric; G protein, monomeric, Rab P51149 7879 3q21.3 human K191-ub 12301985 NEFPEPIkLDKNDRA activity, inhibited carcinogenesis, inhibited; autophagy, inhibited MON1A(DISRUPTS) 33846303 2 4 43 +SNAP23 SNAP23 Vesicle O00161 8773 15q15.1-q15.2 human S110-p 455977 WGDGGENsPCNVVSK SNAP-25 exocytosis, induced 29339438 3 60 1 promoting MVB?PM fusion and the release of CD63-enriched exosomes +SQLE SQLE EC 1.14.13.132; Endoplasmic reticulum; Lipid Metabolism - steroid biosynthesis; Membrane protein, integral; Membrane protein, multi-pass; Oxidoreductase Q14534 6713 8q24.13 human S87-p 1877421602 WAKSPPEsENKEQLE protein degradation; molecular association, regulation; ubiquitination carcinogenesis, inhibited; cell growth, inhibited; apoptosis, induced MARCH6(INDUCES) 35767703 1 0 0 +Adrb2 ADRB2 GPCR, family 1; Membrane protein, integral; Membrane protein, multi-pass; Receptor, GPCR P04274 101836719 hamster Y350-p 449808 RRSSSKAyGNGYSSN molecular association, regulation; receptor desensitization, altered Src iso1(INDUCES) 11278940 8 0 0 +MAPT Tau iso8 ACETYLTRANSFERASE; Acetyltransferase; Cytoskeletal P10636-8 4137 17q21.31 human K274-ac 27738305 KHQPGGGkVQIINKK Tubulin-binding intracellular localization; protein conformation cytoskeletal reorganization TUBA1A(DISRUPTS) 27356871; 31036717 4 0 0 K274Q mutant changes secondary structure of tau; enhances tau aggregation: reducesits ability to induce microtubule bundling in neuroblastoma cells; enhanced the flament formation +Sik1 SIK EC 2.7.11.1; KINASE; Kinase, protein; Motility/polarity/chemotaxis; Protein kinase, CAMK; Protein kinase, Ser/Thr (non-receptor); Tumor suppressor Q60670 17691 17 B1|17 17.25 cM mouse S577-p 465992 FQEGRRAsDTSLTQG molecular association, regulation; intracellular localization transcription, induced; signaling pathway regulation; transcription, altered 14-3-3 beta(INDUCES) 12200423; 12530631; 32457359 10 21 4 PKA-SIK signaling for the regulation of sleep need +MDM2 MDM2 EC 6.3.2.-; EC 6.3.2.19; Inhibitor; Ligase; NEDDYLATION LIGASE; Neddylation Ligase; Nucleolus; Oncoprotein; UBIQUITIN LIGASE; Ubiquitin conjugating system; Ubiquitin ligase Q00987 4193 12q15 human S260-p 454923 SLDSEDYsLSEEGQE activity, induced; protein degradation; molecular association, regulation; ubiquitination; enzymatic activity, induced Rb(DISRUPTS) 12167711; 12383858; 19833129; 21990374 7 1 0 promotes p53 degradation; stimulates p53 turnover; Rb degradation ; Phosphorylated S260 and S395 and S260D and S395D mutant peptides inhibited binding of binding of a specific monoclonal antibody raised to Mdm2. Phosphorylation of Mdm2 regulates p53 degradation. +Trpv1 TRPV1 Channel, cation; Membrane protein, integral; Membrane protein, multi-pass; Receptor, misc. O35433 83810 10q24 rat Y199-p 458384 ASYTDSYyKGQTALH Ank_2 activity, induced 17582331 2 0 0 altered desensitization +BRAF BRAF EC 2.7.11.1; KINASE; Kinase, protein; Oncoprotein; Protein kinase, Ser/Thr (non-receptor); Protein kinase, TKL P15056 673 7q34 human S732-p 23085408 HRSASEPsLNRAGFQ molecular association, regulation; phosphorylation BRAF(DISRUPTS); 14-3-3 beta(DISRUPTS) 37625591 1 0 3 inhibits phosphorylation of itself at T599 and also MEK phosphorylation +Slc2a4 GLUT4 Membrane protein, integral; Membrane protein, multi-pass; Transporter; Transporter, SLC family P19357 25139 10q24 rat S488-p 451207 ATFRRTPsLLEQEVK intracellular localization 9725807 3 11 0 S488A mutation had no effect on localization to cell surface, but vesicle localization was significantly increased. +CLK2 CLK2 EC 2.7.12.1; KINASE; Kinase, protein; Protein kinase, CMGC; Protein kinase, dual-specificity (non-receptor) P49760 1196 1q22 human S34-p 15339201 HKRRRSRsWSSSSDR apoptosis, altered; cell growth, altered 20682768 1 0 0 +RBM7 RBM7 RNA-binding Q9Y580 10179 11q23.2 human S204-p 4033285 QRKVRMNsYPYLADR molecular association, regulation 14-3-3 beta(INDUCES); GADD45A(DISRUPTS) 25189701 1 21 61 14-3-3 protein binding +TWIST1 TWIST1 Cell development/differentiation; DNA-binding; Inhibitor; Transcription regulation Q15672 7291 7p21.1 human K38-ub 58948903 SGKRGGRkRRSSRRS protein stabilization; intracellular localization carcinogenesis, induced; cell motility, induced; cell growth, induced; transcription, induced 27618486 1 0 0 regulates EMT and cancer-stem cell self-renewal +Adcy6 ADCY6 Adenylyl cyclase; EC 4.6.1.1; Lyase; Membrane protein, integral; Membrane protein, multi-pass; Nucleotide Metabolism - purine; Transporter; Transporter, aquaporin family AAA40678 25289 7q36 rat S754-p 467275 IVRSRVHsTAVGVFS enzymatic activity, induced 11327830; 15470083 2 0 0 increases potentiation +Osbpl3 OSBPL3 iso3 Endoplasmic reticulum D3Z194 71720 6|6 B2.3 mouse S302-p 3212430 SGPVRLHsSNPNLST apoptosis, inhibited 31509750 1 11 0 inhibits insulin secretion +LMNA lamin A/C Cytoskeletal P02545 4000 1q22 human T19-p 459855 SGAQASStPLSPTRI molecular association, regulation cell cycle regulation lamin A/C(DISRUPTS) 35839855; 7925482 3 54 56 dominant negative mitotic affects, and mitotic assembly and disassembly of lamin +CYSLTR1 CYSLTR1 GPCR, family 1; Membrane protein, integral; Membrane protein, multi-pass; Receptor, GPCR Q9Y271 10800 Xq21.1 human S315-p 11143521 TFRKHSLsSVTYVPR receptor desensitization, induced transcription, induced 22230957 1 2 2 +HDAC4 HDAC4 DEACETYLASE; Deacetylase; EC 3.5.1.98; Hydrolase; Nuclear receptor co-regulator; SUMO LIGASE P56524 9759 2q37.3 human S632-p 448490 RPLSRAQsSPASATF protein stabilization; molecular association, regulation; intracellular localization transcription, altered 14-3-3 beta(INDUCES); 14-3-3 epsilon(INDUCES) 10869435; 10958686; 24904057 11 40 71 +Tp53 p53 Activator; DNA-binding; Motility/polarity/chemotaxis; Nuclear receptor co-regulator; Transcription factor; Tumor suppressor P10361 24842 10q24 rat K371-ac 458980 SSYPKTKkGQSTSRH activity, induced cell cycle regulation; apoptosis, induced 18192848; 22981429 95 4 0 +STAP2 STAP2 Adaptor/scaffold Q9UGK3 55620 19p13.3 human Y250-p 478353 PFLLDEDyEKVLGYV phosphorylation signaling pathway regulation; transcription, altered 12540842; 35725273 4 3 29 induces phosphorylation of ZAP-70, PLC-g1, ERK, and p38 thus inducing the TCR-proximal signaling pathway +NUMA1 NuMA-1 Cell cycle regulation; Motility/polarity/chemotaxis Q14980 4926 11q13.4 human T1811-p 1245323 TRSARRRtTQIINIT cell growth, induced; apoptosis, inhibited 23097092 2 12 192 cell proliferation increased +PAPOLA PAP-alpha EC 2.7.7.19; RNA processing; RNA splicing; Transferase P51003 10914 14q32.2 human K736-ac 483063 ANPIPVIkNSIKLRL protein stabilization; molecular association, regulation; enzymatic activity, inhibited; intracellular localization CPSF6(DISRUPTS); CFIM25(DISRUPTS) 17172643; 18281463 2 1 0 +BCAR1 P130Cas Adaptor/scaffold; Motility/polarity/chemotaxis P56945 9564 16q23.1 human S639-p 470438 IQSRPLPsPPKFTSQ intracellular localization cell motility, altered 19454314 2 15 0 +SENP3 SENP3 DESUMOYLASE; EC 3.4.22.68; Nucleolus; Protease; Sumo-specific protease Q9H4L4 26168 17p13.1 human S25-p 4172600 PGIPPAYsSPRRERL molecular association, regulation; intracellular localization NPM1(INDUCES) 25288641 1 4 6 ribosome biogenesis-28S rRNA maturation +GRIN2A NMDAR2A Channel, ligand-gated; Membrane protein, integral; Membrane protein, multi-pass Q12879 2903 16p13.2 human S929-p 485949 ADFIQRGsLIMDMVS NMDAR2_C activity, induced; receptor desensitization, inhibited 23503100; 34252035 2 9 0 +Slc12a2 NKCC1 Membrane protein, integral; Membrane protein, multi-pass; Transporter; Transporter, SLC family P55012 20496 18 D3|18 32.15 cM mouse T196-p 467235 HQQYYYDtHTNTYYL AA_permease_N enzymatic activity, induced 26069258 11 1 0 Ischemic cell death +Jak2 JAK2 EC 2.7.10.2; KINASE; Kinase, protein; Oncoprotein; Protein kinase, TK; Protein kinase, tyrosine (non-receptor) Q62120 16452 19 C1|19 23.73 cM mouse Y570-p 451494 VRREVGDyGQLHKTE PK_Tyr_Ser-Thr enzymatic activity, inhibited 15143187; 16705160; 19364823 8 40 825 +TUFM EFTU Mitochondrial; RNA-binding; Translation; Translation elongation P49411 7284 16p11.2 human S222-p 1871246005 ETPVIVGsALCALEG GTP_EFTU molecular association, regulation autophagy, inhibited ATG5(DISRUPTS) 33113344 1 0 0 mitophagy inhibited +CTNND1 CTNND1 Actin-binding; Adaptor/scaffold; Cell adhesion; G protein regulator, misc.; Motility/polarity/chemotaxis O60716 1500 11q12.1 human K547-ub 1873286914 ERSEARRkLRECDGL cell motility, induced; cytoskeletal reorganization 29078376 1 0 0 inhibits Rac1 activation +NELFE RDBP Mitochondrial; Transcription, coactivator/corepressor P18615 7936 6p21.33 human S51-p 454289 GGVKRSLsEQPVMDT molecular association, regulation transcription, induced 14-3-3 epsilon(INDUCES) 29523821 1 50 3 dissociation of the NELF complex from chromatin, which is accompanied by RNA polymerase II elongation +SQSTM1 SQSTM1 Autophagy; Nuclear receptor co-regulator; Ubiquitin conjugating system Q13501 8878 5q35.3 human Y433-p 11112748 AALDTIQySKHPPPL UBA_5 protein stabilization; molecular association, regulation; activity, inhibited carcinogenesis, induced; autophagy, inhibited SQSTM1(INDUCES) 31931029 1 1 2 inhibits cargo function +Marcks MARCKS Actin-binding; Motility/polarity/chemotaxis P26645 17118 10 B1|10 19.49 cM mouse S163-p 451837 SFKLSGFsFKKSKKE MARCKS intracellular localization carcinogenesis, induced; cell motility, altered 20211725 11 76 93 +MAD1L1 MAD1L1 Cell cycle regulation; Cytoskeletal Q9Y6D9 8379 7p22.3 human S214-p 482335 KIQELQAsQEARADH MAD molecular association, regulation; protein conformation; phosphorylation cell cycle regulation; carcinogenesis, induced; DNA repair, induced; signaling pathway regulation Mad2(INDUCES); Ku80(INDUCES) 24728176; 32944396 2 3 2 induces DNAPK phosphorylation, regulates MAD1/KU80 pathway; homodimerization +RASSF1 RASSF1 iso2 Tumor suppressor Q9NS23-2 11186 3p21.31 human S178-p 13258705 VRPVSVPsSKKPPSL molecular association, regulation apoptosis, inhibited TRAIL-R1(DISRUPTS); 14-3-3 zeta(INDUCES); 14-3-3 epsilon(INDUCES); TNF-R1(DISRUPTS); MOAP1(DISRUPTS) 20069457 1 0 0 +ANXA1 ANXA1 Calcium-binding; Lipid-binding P04083 301 9q21.13 human S5-p 452051 ___MAMVsEFLKQAW molecular association, regulation; protein conformation S100A11(DISRUPTS) 21280599 3 8 0 prevents the N-terminal peptide of ANXA1 from adopting an alpha-helical conformation +CXCR2 IL8RB GPCR, family 1; Membrane protein, integral; Membrane protein, multi-pass; Receptor, GPCR; Receptor, cytokine P25025 3579 2q35 human S351-p 451047 SRPSFVGsSSGHTST protein degradation; receptor desensitization, altered; receptor internalization, altered 9079638 1 0 1 +Dync1li1 DNCLI1 Cell cycle regulation; Cytoskeletal; Microtubule-binding; Motility/polarity/chemotaxis; Motor Q9QXU8 252902 8q32 rat T213-p 3217776 ASPQRRAtAAQEDRD DLIC intracellular localization 24778311 1 1 5 virus transport to the nucleus, promotes binding to adenovirus, decrease in dynein activity at lysosomes +Rock2 ROCK2 EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, AGC; Protein kinase, Ser/Thr (non-receptor) Q62868 25537 6q16 rat T414-p 5931301 QLPFIGFtYFRENLL enzymatic activity, inhibited 19099536 1 0 0 in vitro +EIF2AK2 PKR EC 2.7.10.2; EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, Other; Protein kinase, Ser/Thr (non-receptor); Protein kinase, tyrosine (non-receptor); Translation P19525 5610 2p22.2 human T451-p 448089 KRTRSKGtLRYMSPE Pkinase phosphorylation; enzymatic activity, induced apoptosis, induced; transcription, induced; translation, induced 11337501; 34380029; 35354045; 35947956; 9528799 15 1 0 +NCSTN nicastrin Membrane protein, integral Q92542 23385 1q23.2 human S437-p 25533000 FLRARNIsGVVLADH Nicastrin protein degradation; molecular association, regulation 22590650 1 0 0 inhibits gamma-secretase complex formation +Bcl11b Bcl-11B C2H2-type zinc finger protein; Nuclear receptor co-regulator; Transcription regulation Q99PV8 58208 12 F1|12 59.1 cM mouse S381-p 4772890 SSTPPPVsPGRGNPM molecular association, regulation SENP1(INDUCES) 22700985 0 16 56 +SIK3 QSK EC 2.7.11.1; KINASE; Kinase, protein; Motility/polarity/chemotaxis; Protein kinase, CAMK; Protein kinase, Ser/Thr (non-receptor) Q9Y2K2 23387 11q23.3 human S626-p 3216774 FSPVRRFsDGAASIQ molecular association, regulation 14-3-3 beta(INDUCES) 22588126 1 41 6 +Kalrn kalirin EC 2.7.11.1; GEF; GEF, Rac/Rho; KINASE; Kinase, protein; Protein kinase, CAMK; Protein kinase, Ser/Thr (non-receptor) A2CG49 545156 16|16 B3 mouse T1572-p 3363402 EPIQLPKtPAKLRNN enzymatic activity, induced cytoskeletal reorganization 18628310 1 0 1 +GAPDH GAPDH Carbohydrate Metabolism - glycolysis and gluconeogenesis; EC 1.2.1.12; Oxidoreductase P04406 2597 12p13.31 human K251-ac 14791500 DLTCRLEkPAKYDDI Gp_dh_C intracellular localization 20601085 1 0 0 nuclear translocation +DEF6 DEF6 GEF; GEF, Rac/Rho Q9H4E7 50619 6p21.31 human Y222-p 18505504 QDVLKQGyLWKRGHL PH molecular association, regulation; intracellular localization; protein conformation DCP1A(INDUCES) 22829599 1 1 0 cytoplasmic granule formation +Cdk5r1 CDK5R1 Protein kinase, regulatory subunit P61810 116671 10q26 rat T138-p 471393 PAITSAGtPKRVIVQ CDK5_activator protein stabilization apoptosis, inhibited; signaling pathway regulation 17121855; 30770557 8 1 0 regulates p35-p25/CDK5 signaling pathway; decreased phosphorylation in adult compared to prenatal brain correlated with lower resistance to calpain cleavage; +EIF2S1 eIF2-alpha RNA-binding; Translation; Translation initiation P05198 1965 14q23.3 human K143-ac 63112800 WVFDDKYkRPGYGAY EIF_2_alpha apoptosis, induced 27911441 1 1 0 +MAPT Tau iso8 ACETYLTRANSFERASE; Acetyltransferase; Cytoskeletal P10636-8 4137 17q21.31 human K311-ub 486345 GSVQIVYkPVDLSKV Tubulin-binding protein stabilization 16443603 1 3 0 +Myh14 MYH14 Motility/polarity/chemotaxis; Motor Q6URW6 71960 7|7 B3 mouse T1960-p 27623909 PLTFTTRtVRQVFRL cytoskeletal reorganization 23426373 1 0 0 Phosphorylation of either residue abolishes filament assembly of MYH14 Rod1296-1854. +Gja4 GJA4 Cell adhesion; Membrane protein, integral; Membrane protein, multi-pass P28235 14612 4 D2.2|4 61.47 cM mouse S328-p 1867850302 SRPNSSAsKKQYV__ protein conformation cell cycle regulation; apoptosis, induced 30736283 1 0 0 +Nkx2-1 NKX2-1 Cell development/differentiation; DNA-binding; Transcription factor P23441 25628 6q23 rat T9-p 451108 SMSPKHTtPFSVSDI transcription, induced 9211870 2 0 0 T9A mutation reduced transactivation of the surfactant B gene promoter +Hist1h2ail1 H3 DNA-binding Q6LED0 291159 17p11 rat K4-m3 1458621 ____ARTkQTARKST Histone chromatin organization, altered; transcription, induced 21779870 178 10 0 +SRSF1 SF2 RNA splicing; RNA-binding; Spliceosome Q07955 6426 17q22 human R93-m1 476743 VEFPRSGrGTGRGGG intracellular localization RNA splicing, induced; RNA stability, inhibited; translation, induced 20308322 1 7 36 prevents SF2 nuclear import and splicing of target genes, and translation is increased in the cytoplasm +SMC3 SMC3 Cell cycle regulation; DNA repair, damage Q9UQE7 9126 10q25.2 human S1083-p 453061 ESERGSGsQSSVPSV SMC_N molecular association, regulation cell cycle regulation; DNA repair, induced DNA(INDUCES) 18442975; 20501661 5 9 3 cohesin binding sites; required for intra-S phase checkpoint +NF2 Merlin Cytoskeletal; Motility/polarity/chemotaxis; Tumor suppressor P35240 4771 22q12.2 human K269-ub 22247412 RNISYSDkEFTIKPL FERM_C molecular association, regulation; intracellular localization LATS1(DISRUPTS) 30918126 1 4 0 K63 kinked +FRS2 FRS2 Adaptor/scaffold Q8WU20 10818 12q15 human Y196-p 448153 AEEQVHTyVNTTGVQ protein degradation; molecular association, regulation cell differentiation, induced; signaling pathway regulation; endocytosis, inhibited SOS1(INDUCES); GRB2(INDUCES) 11278583; 21625213; 36410439 7 3 9 affects KGFR endocytic trafficking and degradation; activates FGFR1 signaling +Gria1 GluR1 Channel, calcium; Channel, ligand-gated; Membrane protein, integral; Membrane protein, multi-pass P19490 50592 10q22 rat K831-ac 206219721 ALIEFCYkSRSESKR protein stabilization; ubiquitination; receptor internalization, inhibited neural plasticity 28793258 1 0 0 inhibits ubiquitination; impaired learning and memory +CCDC124 CCDC124 Cell cycle regulation Q96CT7 115098 19p13.11 human S122-p 27445755 DTAEKAKsHLEVPLE protein stabilization 23894443 1 3 0 +KCNJ1 ROMK Channel, potassium; Membrane protein, integral; Membrane protein, multi-pass P48048 3758 11q24.3 human Y337-p 451246 SKTKEGKyRVDFHNF IRK_C intracellular localization; activity, inhibited 11719519; 12556363; 19706464 4 0 0 +NHERF1 NHERF Adaptor/scaffold; Motility/polarity/chemotaxis O14745 9368 17q25.1 human T95-p 4047202 LLVVDPEtDEQLQKL phosphorylation 20571032 2 0 0 facilitates phosphorylation of S77 +CALM1 Calmodulin Calcium-binding; Protein phosphatase, regulatory subunit P0DP23 801 14q32.11 human S82-p 448705 RKMKDTDsEEEIREA activity, induced; protein conformation 15461451; 17173306; 36273583 9 16 0 induces CaV1.2 activity +NR4A1 Nur77 Apoptosis; DNA-binding; Nuclear receptor P22736 3164 12q13.13 human S140-p 2591500 GSPCSAPsPSTPSFQ molecular association, regulation cell cycle regulation PIN1(INDUCES) 22002310 3 0 0 required for cell proliferation; interaction with Pin1 enhances Nur77 ability to interact with p300 +INPP5D SHIP iso2 EC 3.1.3.86; Motility/polarity/chemotaxis; Phosphatase, lipid Q92835-2 3635 2q37.1 human Y1021-p 448865 EMFENPLyGSLSSFP intracellular localization 29852247 10 15 202 nucleocytoplasmic shuttling (A mutants show accumulation in nucleus) +TP53 p53 Activator; DNA-binding; Motility/polarity/chemotaxis; Nuclear receptor co-regulator; Transcription factor; Tumor suppressor P04637 7157 17p13.1 human K370-m2 2574934 RAHSSHLkSKKGQST molecular association, regulation transcription, induced PHF20(INDUCES); JMJD2A(INDUCES); 53BP1(INDUCES) DNA(INDUCES) 17805299; 19334741; 33961797 2 2 0 +Usp20 USP20 DEUBIQUITINASE; EC 3.4.19.12; Protease; Ubiquitin conjugating system; Ubiquitin-specific protease Q8C6M1 74270 2|2 B mouse S134-p 469014 ADEGESEsEDDDLKP protein stabilization; molecular association, regulation; ubiquitination signaling pathway regulation AMFR(INDUCES) 33177714 1 46 2 inhibits ubiquitination of HMGCR thus stabilizing it, regulates the mTORC1?USP20?HMGCR pathway +DLG1 DLG1 Adaptor/scaffold; Motility/polarity/chemotaxis Q12959 1739 3q29 human S443-p 5931300 FLGQTPAsPARYSPV PDZ_assoc protein degradation; protein stabilization; ubiquitination; intracellular localization 19066288; 19307009 3 2 10 degraded by HPV E6 oncoprotein in HPV-containing cell lines +TP53 p53 Activator; DNA-binding; Motility/polarity/chemotaxis; Nuclear receptor co-regulator; Transcription factor; Tumor suppressor P04637 7157 17p13.1 human S46-p 447536 AMDDLMLsPDDIEQW TAD2 activity, induced; protein degradation; molecular association, regulation; protein stabilization; acetylation; intracellular localization; protein conformation cell cycle regulation; carcinogenesis, induced; apoptosis, altered; carcinogenesis, inhibited; cell growth, inhibited; apoptosis, induced; transcription, induced; transcription, altered; DNA repair, induced; apoptosis, inhibited; transcription, inhibited; cell growth, altered BAX(INDUCES); S100B(INDUCES); TFB1M(INDUCES); SCO2(INDUCES); S100A1(INDUCES); S100A4(INDUCES); PIN1(INDUCES); CBP(INDUCES); PPP1R13L(DISRUPTS); RPA1(INDUCES); GTF2H1(INDUCES); S100A6(INDUCES); GLS2(INDUCES); S100A2(INDUCES) DNA(INDUCES); DNA(DISRUPTS) 10581258; 11030628; 11740489; 11780126; 12093737; 12397361; 15471885; 15526030; 15706352; 15843377; 15897882; 16247456; 16377624; 16738336; 16793543; 17210684; 17349958; 17349959; 17567906; 17906639; 18160537; 18216278; 18769132; 19465479; 19819244; 19828042; 19965871; 20018442; 20024960; 20171273; 20962272; 21057547; 21394211; 21765463; 22011578; 22525275; 22797063; 22878263; 24379358; 24899407; 25915850; 25944899; 26029824; 26236013; 27034505; 27208501; 33443163; 33906076; 34103685; 34980600; 35227287 115 3 0 +RAD52 RAD52 DNA repair, damage P43351 5893 12p13.33 human K411-sm 13258714 HRKSQDMkKRKYDPS intracellular localization 20190268 1 1 0 +Sqstm1 SQSTM1 Autophagy; Nuclear receptor co-regulator; Ubiquitin conjugating system O08623 113894 10q22 rat S293-p 31872178 SSCSSEVsKPDGAGE intracellular localization autophagy, induced 28655770 1 2 0 localization in mitochondria +F2RL1 F2RL1 GPCR, family 1; Membrane protein, integral; Membrane protein, multi-pass; Receptor, GPCR P55085 2150 5q13.3 human S383-p 25291197 SKKHSRKsSSYSSSS receptor desensitization, induced; molecular association, regulation; phosphorylation signaling pathway regulation ARRB1(INDUCES); ARRB2(INDUCES) 33073187 1 0 1 inhibits ERK phosphorylation and signaling; regulates calcium signaling +Ulk1 ULK1 Autophagy; EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, Other; Protein kinase, Ser/Thr (non-receptor) O70405 22241 5|5 F mouse S774-p 4699305 STRTRMFsVGSSSSL signaling pathway regulation 21819378 1 4 2 signaling for autophagy regulation +Fgfr1 FGFR1 EC 2.7.10.1; KINASE; Kinase, protein; Membrane protein, integral; Oncoprotein; Protein kinase, TK; Protein kinase, tyrosine (receptor) P16092 14182 8 A2|8 14.12 cM mouse Y766-p 447922 ALTSNQEyLDLSIPL molecular association, regulation cell cycle regulation; transcription, altered; cell growth, altered SHB(INDUCES) 12181353; 9694798 10 1 0 Y766F mutation causes embryonic transformations in vertebral column. +PRKDC DNAPK DNA repair, damage; EC 2.7.11.1; KINASE; Kinase, protein; Nucleolus; Protein kinase, Ser/Thr (non-receptor); Protein kinase, atypical P78527 5591 8q11.21 human S2029-p 33365501 PSYMSSLsYLADSTL DNAPKcs_CC3 molecular association, regulation DNA repair, inhibited DNA(INDUCES) 24687855 1 0 0 induces c-NHEJ, restricts end processing +MAPT Tau iso8 ACETYLTRANSFERASE; Acetyltransferase; Cytoskeletal P10636-8 4137 17q21.31 human S320-p 450139 VDLSKVTsKCGSLGN Tubulin-binding protein stabilization cytoskeletal reorganization 10090741; 15652175 4 0 0 promotes stability of helix structure and microtubule polymerization in vitro. +AKT1 Akt1 EC 2.7.11.1; KINASE; Kinase, protein; Oncoprotein; Protein kinase, AGC; Protein kinase, Ser/Thr (non-receptor) P31749 207 14q32.33 human S124-p 450018 EMDFRSGsPSDNSGA enzymatic activity, induced carcinogenesis, induced 36114575; 9690513 5 29 0 +C2orf88 smAKAP Q9BSF0 84281 2q32.2 human S66-p 54468602 LEYAHRLsQDILCDA SmAKAP molecular association, regulation; protein conformation PKACA(DISRUPTS) 27028580 1 1 0 +NKAP NKAP Unknown function Q8N5F7 79576 Xq24 human S9-p 14576893 APVSGSRsPDREASG intracellular localization transcription, induced; signaling pathway regulation 31461649 1 16 1 enhances NF-KB nuclear localization, regulates PTEN/NKAP/NF-KB/PDHK1 signaling +FANCD2 FANCD2 DNA repair, damage Q9BXW9 2177 3p25.3 human S717-p 453231 KDGGPVTsQESGQKL FancD2 activity, induced cell cycle regulation 16943440 1 8 0 promotes monoubiquitination of FANCD2 +E2F1 E2F1 DNA-binding; Transcription factor Q01094 1869 20q11.22 human R111-me 57676507 SSGPARGrGRHPGKG protein degradation; molecular association, regulation; ubiquitination; methylation cell cycle regulation; carcinogenesis, induced; cell growth, induced; apoptosis, inhibited; transcription, inhibited TSN(INDUCES) DNA(DISRUPTS) 22327218; 24076217 2 1 0 inhibits asymmetrical methylation. Binding to TSN regulates binding of TSN to DNA +POLI POLI DNA repair, damage; EC 2.7.7.7; Transferase Q9UNA4 11201 18q21.2 human K574-ub 50771306 GVLSFFSkKQMQDIP protein degradation 26370087 1 1 0 +PXN PXN Adaptor/scaffold; Cell adhesion; Cytoskeletal; Motility/polarity/chemotaxis P49024 395832 chicken S457-p 448768 AILENYIsALNTLWH LIM intracellular localization 9658172 1 0 0 +Nos3 eNOS Amino Acid Metabolism - arginine and proline; EC 1.14.13.39; Oxidoreductase P70313 18127 5 A3|5 11.32 cM mouse S1178-p 467802 RIRTQSFsLQERQLR intracellular localization 17982133 11 8 1 S1177 appears in cell membranes and perinuclear golgi and significant difference of protein expression between the LC and GC regions of aorta ascending archplate. +MRPS23 MRPS23 Mitochondrial; Ribosomal; Translation Q9Y3D9 51649 17q22 human K108-m2 1881582601 EKYTELQkLGETDEE protein degradation; ubiquitination cell motility, induced 33927350 1 0 0 promote degradation to a low level +Cebpa C/EBP-alpha DNA-binding; Transcription factor P05554 24252 1q21 rat S230-p 447618 PPPTPVPsPHPAPAM activity, inhibited transcription, altered 16600022 4 0 0 In 3T3L1 preadipocytes, mutation of T222/T226 to alanines increased transcription at CBE-containing promoter (as compared to WT C/EBP-alpha). S230A had a similar effect as the double T->A mutation. The triple alanine mutation had the highest transcription of the reporter gene. S230A did not reduce T222/226 phosphorylation (although CHIR99021 inhibitor did). +PPP1R14A PPP1R14A Inhibitor; Protein phosphatase, regulatory subunit Q96A00 94274 19q13.2 human T38-p 449098 QKRHARVtVKYDRRE PP1_inhibitor receptor desensitization, altered; activity, inhibited cell motility, altered 12144526; 12495628 29 0 0 inhibition of MLCP activity, activates contractile response in arterial smooth muscle; Phosphorylation at T38-CPI-17 was required for induction of cerebellar long-term synaptic depression +Hsf1 HSF1 iso2 DNA-binding; Transcription factor P38532-2 15499 15 D3|15 35.95 cM mouse S326-p 455484 SSMDTPLsPTAFIDS Vert_HS_TF carcinogenesis, induced; cell growth, induced 35906200 48 25 13 +AGAP2 CENTG1 iso2 GAP; GAP, ARF; Motility/polarity/chemotaxis; Tumor suppressor Q99490-2 116986 12q14.1 human Y682-p 467224 ESWIRAKyEQLLFLA ArfGap molecular association, regulation; protein stabilization apoptosis, altered; cell growth, induced AMPKA2(INDUCES) 16841086; 26001218 2 0 0 +ELP1 IKBKAP Protein kinase, regulatory subunit; Transcription regulation O95163 8518 9q31.3 human S1174-p 3178326 SETSSVVsGSEMSGK activity, induced 29925953 1 2 0 regulates elongator activity, cell survival induced +Irf6 IRF6 DNA-binding; Transcription factor P97431 54139 1 H6|1 97.6 cM mouse S90-p 56649936 LRCALNKsREFNLMY IRF activity, induced cell differentiation, induced; transcription, induced 31578523 1 2 0 +RBBP8 CtIP EC 3.1.-.-; Transcription, coactivator/corepressor Q99708 5932 18q11.2 human K515-ac 33625701 GSETSKNkFRQVTLY enzymatic activity, induced 24837676 1 1 0 +NUAK1 NuaK1 EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, CAMK; Protein kinase, Ser/Thr (non-receptor) O60285 9891 12q23.3 human T211-p 456032 QKDKFLQtFCGSPLY Pkinase enzymatic activity, induced cell cycle regulation; cell growth, inhibited; cell growth, altered 16488889; 19927127; 21317932 5 1 1 +NAA10 NAA10 ACETYLTRANSFERASE; Acetyltransferase; Amino Acid Metabolism - phenylalanine; Amino Acid Metabolism - tyrosine; EC 2.3.1.88; Lipid Metabolism - glycerophospholipid; Secondary Metabolites Metabolism - limonene and pinene degradation P41227 8260 Xq28 human S228-p 3190219 STDVKDSsEASDSAS phosphorylation autophagy, inhibited PGK1(DISRUPTS) 28238651 1 7 2 inhibits Beclin1 phosphorylation +ATRIP ATRIP Cell cycle regulation; DNA repair, damage; DNA-binding Q8WXE1 84126 3p21.31 human S224-p 485778 APSVSHVsPRKNPSV cell cycle regulation 17638878 1 38 5 important for the G2-M checkpoint arrest in response to DNA damage +Cdc25b CDC25B EC 3.1.3.48; Motility/polarity/chemotaxis; Nuclear receptor co-regulator; PHOSPHATASE; Protein phosphatase, dual-specificity P30306 12531 2 F1|2 63.29 cM mouse S321-p 448409 QRLFRSPsMPCSVIR M-inducer_phosp intracellular localization; phosphorylation cell cycle regulation 18633139; 21212267; 22348958 13 9 30 +Rcan1 RCAN1 Inhibitor Q9JHG6 54720 16 C4|16 53.6 cM mouse T177-p 8142805 WKQVEDAtPVINYDL Calcipressin molecular association, regulation PPP3CA(DISRUPTS) 22864830 2 1 6 +F2RL1 F2RL1 GPCR, family 1; Membrane protein, integral; Membrane protein, multi-pass; Receptor, GPCR P55085 2150 5q13.3 human T391-p 12184123 SSYSSSStTVKTSY_ receptor desensitization, induced; molecular association, regulation; phosphorylation signaling pathway regulation ARRB1(INDUCES); ARRB2(INDUCES) 33073187 1 0 1 inhibits ERK phosphorylation and signaling; regulates calcium signaling +PRKCD PKCD EC 2.7.11.13; KINASE; Kinase, protein; Nuclear receptor co-regulator; Protein kinase, AGC; Protein kinase, Ser/Thr (non-receptor); Protein kinase, tyrosine (non-receptor); Tumor suppressor Q05655 5580 3p21.1 human K475-sm 1881459303 GIIYRDLkLDNVLLD sumoylation; protein stabilization apoptosis, induced 34089566 1 0 0 promotes apoptosis induced by H2O2; phosphorylation induces sumoylation which reciprocally induces phosphorylation +H4C1 H4 DNA-binding P62805 8359 6p22.2 human K5-ac 458958 ___SGRGkGGKGLGK protein stabilization; acetylation; molecular association, regulation cell cycle regulation; cell growth, inhibited; transcription, induced; transcription, altered; DNA repair, induced; chromatin organization, altered; cell differentiation, induced; cell growth, induced TBN(INDUCES); BRDT(INDUCES); CGI-09(INDUCES); PUS1(INDUCES); SETD8(DISRUPTS); THOC4(INDUCES); TAF4(INDUCES); BRD4(INDUCES); BRD2(INDUCES) DNA(DISRUPTS) 18179771; 18418072; 18628788; 18985155; 19805290; 19828451; 20043883; 20709061; 20720004; 21047799; 21726812; 23653357; 23970329; 31881804; 35876654; 36961817 72 22 516 decline of histone marks was more notable in H4K5ac and H4K12ac; LINC00839 promotes oxidative phosphorylation (OXPHOS), mitochondrial biogenesis and CRC progression +STAT3 STAT3 DNA-binding; Motility/polarity/chemotaxis; Nuclear receptor co-regulator; Transcription factor P40763 6774 17q21.2 human K87-ac 461011 QHNLRRIkQFLQSRY STAT_int activity, induced; molecular association, regulation; intracellular localization transcription, induced p300(INDUCES) 16285960; 18782771 4 1 0 affects nuclear-cytoplasmic redistribution of the protein; induces enhanceosome formation +NEDD1 NEDD1 Cell cycle regulation Q8NHV4 121441 12q23.1 human S426-p 9379002 VNKGSDEsIGKGDGF molecular association, regulation cell cycle regulation 19509060 2 3 0 important for binding of NEDD1 with gamma-tubulin +KRT18 K18 Cytoskeletal; Nucleolus P05783 3875 12q13.13 human S49-gl 6778603 SGSRISVsRSTSFRG phosphorylation apoptosis, inhibited 20729838 3 0 0 K18?Gly? mutation alters protein kinase phosphorylation and promotes apoptosis in response to STZ treatment; Akt1 Thr 308 phosphorylation increased 12 h after STZ treatment in livers of mice expressing wild-type K18, but in K18?Gly? inhibits Akt1 Thr 308 phosphorylation; glycosylation promotes th the phosphorylation and activation of cell-survival kinases +KIF14 KIF14 Microtubule-binding; Motor Q15058 9928 1q32.1 human S607-p 114810406 NLIDLAGsERCSTAH Kinesin intracellular localization 28630147 1 0 0 spindle localization of Kif14 in anaphase +PFKM PFKM Carbohydrate Metabolism - fructose and mannose; Carbohydrate Metabolism - galactose; Carbohydrate Metabolism - glycolysis and gluconeogenesis; Carbohydrate Metabolism - pentose phosphate pathway; EC 2.7.1.11; Kinase, other P08237 5213 12q13.11 human S762-p 55569802 YEIDLDTsDHAHLEH enzymatic activity, inhibited 27153534 1 2 0 +Wnk4 WNK4 EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, Other; Protein kinase, Ser/Thr (non-receptor) Q80UE6 69847 11|11 D mouse K390-ub 40323306 RKVTSGTkPNSFYKV Pkinase protein degradation 23576762 1 1 0 regulates electrolyte homeostasis and involved in Pseudohypoaldosteronism type II (PHAII) pathogenesis +RUNX1 AML1 iso8 DNA-binding; Oncoprotein; Transcription factor Q01196-8 861 21q22.12 human R237-me 2363102 QLRRTAMrVSPHHPA apoptosis, induced; transcription, induced 32573733 2 1 0 +BBOX1 BBOX1 Amino Acid Metabolism - lysine degradation; EC 1.14.11.1; Oxidoreductase O75936 8424 11p14.2 human K240-ub 27179485 DGFNVCQkLKKNNPQ TauD protein degradation carcinogenesis, induced 35775648 1 2 0 promotes CRIP1-induced cancer stem-like properties in HCC +SLBP SLBP RNA-binding Q14493 7884 4p16.3 human T171-p 11003653 QPGIHPKtPNKFKKY SLBP_RNA_bind molecular association, regulation; intracellular localization; protein conformation SLBP(DISRUPTS); PIN1(INDUCES) RNA(INDUCES) 16492733; 22907757; 23286197; 25002523 3 10 28 crystal structure of human T171 phosphorylated SLBP +HDAC4 HDAC4 DEACETYLASE; Deacetylase; EC 3.5.1.98; Hydrolase; Nuclear receptor co-regulator; SUMO LIGASE P56524 9759 2q37.3 human S265-p 4737971 QKVAERRsSPLLRRK activity, induced; intracellular localization transcription, inhibited 23652597; 29472387; 30661366 4 15 0 transcription of MEF2 target genes RhoB and Klf2 +SP1 SP1 C2H2-type zinc finger protein; DNA-binding; Transcription factor P08047 6667 12q13.13 human S7-p 2535902 _MSDQDHsMDEMTAV protein degradation 18239466 1 23 0 +BECN1 beclin 1 Adaptor/scaffold; Autophagy; Membrane protein, peripheral Q14457 8678 17q21.31 human S30-p 7446159 QPLKLDTsFKILDRV protein conformation; enzymatic activity, induced carcinogenesis, induced; autophagy, induced; cell growth, induced 26118643; 28238651; 29313410 5 6 0 induces activity of the PIK3C3 complex +EGFR EGFR EC 2.7.10.1; KINASE; Kinase, protein; Membrane protein, integral; Oncoprotein; Protein kinase, TK; Protein kinase, tyrosine (receptor) P00533 1956 7p11.2 human K728-ub 1065316 GAFGTVYkGLWIPEG PK_Tyr_Ser-Thr protein degradation 17940017 1 3 0 +SIRT2 SIRT2 DEACETYLASE; Deacetylase; EC 3.5.1.- Q8IXJ6 22933 19q13.2 human Y104-p 479395 RSPSTGLyDNLEKYH SIR2 protein degradation apoptosis, induced; transcription, inhibited 24996174 1 0 3 transcription of p53 was attenuated; SIRT2 levels and stability decreases after phosphorylation; apoptosis augmented by c-Src SIRT2 downregulation +NF2 Merlin Cytoskeletal; Motility/polarity/chemotaxis; Tumor suppressor P35240 4771 22q12.2 human K396-ub 12104551 QITEEEAkLLAQKAA ERM_helical molecular association, regulation; intracellular localization; phosphorylation carcinogenesis, inhibited; cell growth, inhibited; transcription, inhibited; signaling pathway regulation LATS1(DISRUPTS); LATS1(INDUCES) 30918126; 33058421 2 10 3 induces Hippo pathway, induces LATS1/YAP/TAZ phosphorylation; K63 kinked +Slc12a5 KCC2 Membrane protein, integral; Membrane protein, multi-pass; Transporter; Transporter, SLC family Q91V14 57138 2|2 H3 mouse Y1109-p 3087801 NRNGDENyMEFLEVL SLC12 protein degradation 20600929 3 0 0 decreases the cell surface stability of SLC12A5 (aka KCC2) +Ulk1 ULK1 Autophagy; EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, Other; Protein kinase, Ser/Thr (non-receptor) O70405 22241 5|5 F mouse T653-p 23070978 ARQGVVMtPPRNRTL cell cycle regulation; autophagy, induced; cell growth, induced 32516310 1 2 1 +L3MBTL2 L3MBTL2 Histone-binding Q969R5 83746 22q13.2 human S335-p 1046182902 RLEVVDKsQVSRTRM MBT molecular association, regulation; intracellular localization MDC1(INDUCES) 29581593 1 0 0 +CNKSR1 CNK1 Adaptor/scaffold; G protein regulator, misc. Q969H4 10256 1p36.11 human K414-ac 206219717 DGWLLLRkAPGGFMG PH molecular association, regulation; intracellular localization; phosphorylation cell motility, induced; cell growth, induced; signaling pathway regulation RAF1(INDUCES) 28819643 1 0 0 ERK phosphorylation. Stimulates RAF/MEK/ERK pathway and mediates oncogenic RAS signaling +MTURN MTURN Q8N3F0 222166 7p14.3 human S58-p 149319100 GDNFHVWsESEDCLP DUF4581 molecular association, regulation transcription, induced IKKA(DISRUPTS); IKKB(DISRUPTS) 28704656 1 0 0 loss of the ability to inhibit virus-triggered signaling +PPP1R16B PPP1R16B Motility/polarity/chemotaxis; Protein phosphatase, regulatory subunit Q96T49 26051 20q11.23 human S337-p 486245 SSLSRRTsSAGSRGK phosphorylation 31315927 2 0 0 increases phosphorylation of MLC2 +NSF NSF Adaptor/scaffold; Autophagy; EC 3.6.4.6; Protease; Vesicle P46459 4905 17q21.31 human T645-p 53340201 RKLLIIGtTSRKDVL AAA enzymatic activity, induced 26758690 1 1 0 increases NSF ATPase activity, increases the rate of SNARE complex disassembling +Mark2 MARK2 EC 2.7.11.1; EC 2.7.11.26; KINASE; Kinase, protein; Protein kinase, CAMK; Protein kinase, Ser/Thr (non-receptor) O08679 60328 1q43 rat S92-p 26573804 DKTQLNSsSLQKLFR Pkinase cytoskeletal reorganization 17442826 1 0 0 neurite outgrowth +CALD1 Caldesmon Actin-binding P12957 373965 chicken S635-p 457432 AVVSKIDsRLEQYTS Caldesmon molecular association, regulation Caldesmon(DISRUPTS) 20858431 1 6 0 enhances effect of S672 and S702 phosphorylation to weaken interaction +ITGB1 ITGB1 Cell adhesion; Cell surface; Membrane protein, integral; Motility/polarity/chemotaxis; Receptor, misc. P07228 374058 chicken S790-p 452040 GENPIYKsAVTTVVN Integrin_b_cyt cell motility, altered; cell adhesion, altered 11559760 5 11 17 +GIT2 GIT2 GAP; GAP, ARF; Motility/polarity/chemotaxis Q9Y621 374035 chicken Y286-p 456753 EELAMYVyDEVDRRE GIT_SHD molecular association, regulation; intracellular localization cell adhesion, altered PXN(INDUCES) 16000375 1 0 0 +Trpv1 TRPV1 Channel, cation; Membrane protein, integral; Membrane protein, multi-pass; Receptor, misc. O35433 83810 10q24 rat T704-p 487542 WKLQRAItILDTEKS activity, induced; receptor desensitization, altered RNUXA(INDUCES) 14523239; 14630912; 17869438; 33180962 6 0 0 +EPAS1 HIF2A DNA-binding; Transcription factor Q99814 2034 2p21 human S383-p 59087903 SSGKGAVsEKSNFLF intracellular localization transcription, induced 27686097 1 1 0 EPO secretion, inhibits CRM1-dependent nuclear export of HIF2A +Myf6 Myf-6 DNA-binding; Transcription factor P15375 17878 10 D1|10 55.96 cM mouse S31-p 2907504 PLEVAEGsPLYPGSD Basic cell differentiation, altered; transcription, inhibited 14739931 1 0 0 +PDE4C PDE4C iso2 EC 3.1.4.53; Nucleotide Metabolism - purine; Phosphodiesterase Q08493-2 5143 19p13.11 human S13-p 458390 PHSQRREsFLYRSDS enzymatic activity, induced 12023945 1 20 1 +MAP3K7 TAK1 EC 2.7.11.25; KINASE; Kinase, protein; Protein kinase, Ser/Thr (non-receptor); Protein kinase, TKL O43318 6885 6q15 human T184-p 454876 GTACDIQtHMTNNKG PK_Tyr_Ser-Thr phosphorylation; enzymatic activity, induced signaling pathway regulation 10838074; 18617512; 19223549; 20538596; 31387937; 31511642; 36270986 20 0 0 induces TAK1-ADAM17 signaling; induces MAPK and NF-kB signaling pathways by inducing phosphorylation of JNK and ERK +Creb1 CREB iso1 DNA-binding; Transcription factor P15337-1 81646 9q32 rat S114-p 451809 ESEDSQEsVDSVTDS pKID transcription, altered 9931297 8 1 1 +SH3GL2 endophilin A1 Adaptor/scaffold; Membrane protein, peripheral; Vesicle Q99962 6456 9p22.2 human T14-p 457634 KKQFHKAtQKVSEKV BAR molecular association, regulation SH3KBP1(DISRUPTS) 16164598 1 0 0 +Sstr3 SSTR3 GPCR, family 1; Membrane protein, integral; Membrane protein, multi-pass; Receptor, GPCR P30935 20607 15 E1|15 37.55 cM mouse T357-p 456711 GSGPPEKtEEEEDEE intracellular localization 26503786 2 0 0 SST binds to SSTR3 3 on the ciliary membrane and may lead to phosphorylation of residue T357, which facilitates ?-arrestin 2 ciliary localization +DRD2 DRD2 GPCR, family 1; Membrane protein, integral; Membrane protein, multi-pass; Receptor, GPCR P14416 1813 11q23.2 human K226-ub 1877221607 RRKRVNTkRSSRAFR 7tm_1 protein degradation 32572597 1 0 0 +HADHA HADHA ACETYLTRANSFERASE; Acetyltransferase; Amino Acid Metabolism - lysine degradation; Amino Acid Metabolism - tryptophan; Amino Acid Metabolism - valine, leucine and isoleucine degradation; Carbohydrate Metabolism - butanoate; Carbohydrate Metabolism - propanoate; EC 1.1.1.211; EC 4.2.1.17; Lipid Metabolism - fatty acid; Lipid Metabolism - fatty acid elongation in mitochondria; Lipid Metabolism - unsaturated fatty acid biosynthesis; Lyase; Mitochondrial; Other Amino Acids Metabolism - beta-alanine; Oxidoreductase; Secondary Metabolites Metabolism - limonene and pinene degradation P40939 3030 2p23.3 human K350-ub 27192507 YHGQVLCkKNKFGAP protein degradation; ubiquitination 27457618 1 1 0 +MYL2 MRLC2V Contractile P10916 4633 12q24.11 human Y118-p 473229 KGVLKADyVREMLTT molecular association, regulation; phosphorylation cell cycle regulation; carcinogenesis, induced; cell growth, induced ROCK2(INDUCES) 25412762 1 4 128 induces phosphorylation at S15, regulates cytokinesis +HDAC4 HDAC4 DEACETYLASE; Deacetylase; EC 3.5.1.98; Hydrolase; Nuclear receptor co-regulator; SUMO LIGASE P56524 9759 2q37.3 human S467-p 448489 RPLGRTQsAPLPQNA molecular association, regulation; intracellular localization cell cycle regulation; carcinogenesis, induced; apoptosis, inhibited; transcription, induced; transcription, altered 14-3-3 beta(INDUCES); LATS2(DISRUPTS); 14-3-3 epsilon(INDUCES); YAP1(INDUCES) 10869435; 10958686; 35780183 7 18 23 +Il1a IL1A Cytokine; Motility/polarity/chemotaxis P01582 16175 2 F1|2 62.9 cM mouse S90-p 451281 ILKKRRLsFSETFTE IL1_propep molecular association, regulation PLD6(INDUCES) 33361152 2 1 0 +CNN1 calponin 1 Actin-binding; Contractile; Motility/polarity/chemotaxis; Myosin-binding P26932 396522 chicken T259-p 469596 GASQQGMtVYGLPRQ Calponin molecular association, regulation ACTA1(DISRUPTS) 10873572 1 1 1 f-actin (rabbit skeletal muscle) shown by co-sedimentation +FBF1 FBF1 Q8TES7 85302 17q25.1 human S334-p 27449008 QSPPMASsPIQPRKG molecular association, regulation cell cycle regulation PLK1(INDUCES) 30318703 1 4 0 centrosome seperation +PTK2 FAK EC 2.7.10.2; KINASE; Kinase, protein; Protein kinase, TK; Protein kinase, tyrosine (non-receptor) Q05397 5747 8q24.3 human S695-p 25291278 EERMRMEsRRQATVS phosphorylation; enzymatic activity, induced cell motility, induced; cell adhesion, inhibited 23264741 1 0 1 induces phosphorylation at T700 +H4C1 H4 DNA-binding P62805 8359 6p22.2 human Y88-p 457867 VTAMDVVyALKRQGR CENP-T_C cell growth, induced; transcription, induced; translation, induced 28609657 3 28 1036 ACK kinase activity drives AR Eepression in an androgen-deficient environment +TH TH iso3 Amino Acid Metabolism - tyrosine; EC 1.14.16.2; Endoplasmic reticulum; Mitochondrial; Oxidoreductase; Vesicle P07101-3 7054 11p15.5 human S19-p 448542 KGFRRAVsELDAKQA TOH_N molecular association, regulation; enzymatic activity, induced 14-3-3 zeta(INDUCES); 14-3-3 gamma(INDUCES) 12421349; 19801645; 24947669; 33456492 46 9 4 +SMAD4 SMAD4 DNA-binding; Nuclear receptor co-regulator; Transcription, coactivator/corepressor Q13485 4089 18q21.2 human T277-p 449628 GSRTAPYtPNLPHHQ activity, induced; molecular association, regulation; intracellular localization; phosphorylation transcription, induced TIF1A(DISRUPTS); USP9X(INDUCES) 25373906; 28115363 3 0 0 a priming site for T269, T265 and T273 phosphorylations +Ankrd2 ANKRD2 Contractile Q9WV06 56642 19|19 C3 mouse S68-p 480101 QERVRKTsLDLRREI cell differentiation, inhibited 21737686 2 6 8 inhibits muscle differentiation +CD93 CD93 Cell adhesion; Membrane protein, integral Q9NPY3 22918 20p11.21 human Y644-p 463128 SRAMENQySPTPGTD molecular association, regulation cell motility, induced; cell adhesion, induced CBL(INDUCES) 26848865 1 4 21 CD93 binds to Cbl inducing phosphorylation on tyrosine 774 of CBL +BRCA1 BRCA1 EC 6.3.2.-; Nuclear receptor co-regulator; Transcription, coactivator/corepressor; Tumor suppressor; UBIQUITIN LIGASE; Ubiquitin conjugating system; Ubiquitin ligase P38398 672 17q21.31 human S1524-p 448038 LQNRNYPsQEELIKV molecular association, regulation; ubiquitination; phosphorylation cell cycle regulation; carcinogenesis, induced; DNA repair, induced; DNA repair, altered; transcription, induced ATM(INDUCES); claspin(INDUCES) 10550055; 12183412; 15096610; 15159397; 26320175; 33568520; 34610268 15 18 2 inhibits TOP2B ubiquitination +SKP2 SKP2 Cell cycle regulation; UBIQUITIN LIGASE; Ubiquitin conjugating system; Ubiquitin ligase Q13309 6502 5p13.2 human T417-p 15165300 WGIKCRLtLQKPSCL activity, induced; protein stabilization; ubiquitination cell cycle regulation 20663873 1 0 0 +ERBB3 HER3 EC 2.7.10.1; KINASE; Kinase, protein; Membrane protein, integral; Oncoprotein; Protein kinase, TK; Protein kinase, tyrosine (receptor) P21860 2065 12q13.2 human Y1197-p 448640 EEDEDEEyEYMNRRR molecular association, regulation; enzymatic activity, induced carcinogenesis, induced; cell growth, induced; cell motility, induced; apoptosis, inhibited; signaling pathway regulation GRB2(INDUCES); GRB7(INDUCES); PIK3R2(INDUCES); PIK3R1(INDUCES) 16729043; 21725367; 34320350; 9516479 7 3 24 Grb2 binding is reduced campared with Grb7.; induces ERBB3/PI3K/mTOR pathway; chemotaxis and invasion +CSNK1E CK1E EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, CK1; Protein kinase, Ser/Thr (non-receptor) P49674 1454 22q13.1 human S408-p 453421 RIPASQTsVPFDHLG enzymatic activity, inhibited 10542239; 12223474 2 14 10 some subset of these 8 sites +CDC6 CDC6 Cell cycle regulation Q99741 990 17q21.2 human T37-p 17481900 SDAKLEPtNVQTVTC molecular association, regulation cell cycle regulation CDK1(INDUCES) 21041660 1 0 0 +WASF2 WAVE2 Actin-binding; Motility/polarity/chemotaxis Q9Y6W5 10163 1p36.11 human S484-p 6377638 IAVEYSDsEDDSSEF activity, inhibited cytoskeletal reorganization 19012317 1 0 1 +PTPN3 PTPN3 EC 3.1.3.48; Motility/polarity/chemotaxis; PHOSPHATASE; Protein phosphatase, tyrosine (non-receptor) P26045 5774 9q31.3 human S459-p 25594501 QKSSSSVsPSSNAPG protein stabilization; enzymatic activity, induced carcinogenesis, induced; cell growth, induced; apoptosis, inhibited 22730326; 26079946 2 1 0 +YY1 YY1 C2H2-type zinc finger protein; Cell development/differentiation; Transcription factor P25490 7528 14q32.2 human Y383-p 41608702 IHTGDRPyVCPFDGC zf-C2H2 activity, inhibited transcription, inhibited DNA(DISRUPTS); RNA(DISRUPTS) 26198631 1 0 0 4-5 fold decrease in c-fos mRNA +Syk Syk EC 2.7.10.2; KINASE; Kinase, protein; Protein kinase, TK; Protein kinase, tyrosine (non-receptor) P48025 20963 13 A5|13 27.41 cM mouse S291-p 1983707 ISRIKSYsFPKPGHK molecular association, regulation PHB(INDUCES) 20956537 4 11 23 +PGK1 PGK1 Carbohydrate Metabolism - glycolysis and gluconeogenesis; EC 2.7.2.3; KINASE; Kinase, other P00558 5230 Xq21.1 human K388-ac 33346909 AKWNTEDkVSHVSTG PGK molecular association, regulation carcinogenesis, induced; autophagy, induced; cell growth, induced beclin 1(INDUCES) 28238651 1 4 0 +FADD FADD Adaptor/scaffold; Apoptosis Q13158 8772 11q13.3 human K125-sm 62489901 QLKVSDTkIDSIEDR Death molecular association, regulation; intracellular localization CASP10(INDUCES); DRP1(INDUCES) 27799292 1 0 0 +PDS5A SCC-112 Cell cycle regulation Q29RF7 23244 4p14 human S1278-p 3965429 GRRPKSEsQGNATKN cell cycle regulation; chromatin organization, altered 36469004 1 2 12 +NCOR1 N-CoR1 Nuclear receptor co-regulator; Transcription, coactivator/corepressor O75376 9611 17p12-p11.2 human S70-p 3828921 QQLRRRPsLLSEFHP intracellular localization transcription, inhibited AR(INDUCES) 23129261 1 12 79 increases nuclear translocation, inhibits transcription of PSA and NKX3.1 +BRD7 BRD7 Cell cycle regulation; Histone-binding; Transcription regulation; Tumor suppressor Q9NPI1 29117 16q12.1 human K182-ub 964501744 PMDFSTMkEKIKNND Bromodomain protein degradation cell motility, induced; cell growth, inhibited USP24(INDUCES) 33257797 1 1 0 +POLR2M GRINL1A Channel, ligand-gated; Nuclear envelope; Transferase P0CAP2 81488 15q21.3 human S270-p 3209253 SHCQKSGsPISSEER molecular association, regulation transcription, altered POLR2A(DISRUPTS) 24634214 1 14 0 Phosphorylated Gdown1 inhibited TTF2 and TFIIF +NFATC1 NFAT2 DNA-binding; Transcription factor O95644 4772 18q23 human S151-p 56629000 VLPSSKRsPSTATLS activity, induced carcinogenesis, induced; cell motility, induced; transcription, induced 31730483 2 2 0 multiple sites mutatnt +Gphn gephyrin Adaptor/scaffold; EC 2.10.1.1; EC 2.7.7.75 Q8BUV3 268566 12|12 C3 mouse S268-p 483463 ASLSTTPsESPRAQA receptor internalization, induced; protein degradation neural plasticity 35245123 5 6 2 induces GABAAR internalization +Chpt1 CHPT1 EC 2.7.8.2; Lipid Metabolism - ether lipid; Lipid Metabolism - glycerophospholipid; Membrane protein, integral; Membrane protein, multi-pass; Transferase Q8C025 212862 10|10 C1 mouse K311-ub 12718511 VFAKVAQkLVIAHMT TM protein degradation; enzymatic activity, inhibited 20018880 1 0 0 +TGIF2 TGIF2 DNA-binding Q9GZN2 60436 20q11.23 human T182-p 25174052 PTGGLFNtPPPTPPE molecular association, regulation carcinogenesis, induced; cell motility, induced; transcription, altered HDAC1(INDUCES) DNA(INDUCES) 36647029 1 5 0 +NEFL NFL Cytoskeletal P07196 4747 8p21.2 human T21-p 2872004 YKRRYVEtPRVHISS Filament_head molecular association, regulation NFL(DISRUPTS) 16452125 1 1 0 +LMNA lamin A/C Cytoskeletal P02545 4000 1q22 human S403-p 456874 QRSRGRAsSHSSQTQ intracellular localization 7925482 1 29 80 nuclear transport of lamin +Rela NFkB-p65 DNA-binding; Nuclear receptor co-regulator; Transcription factor Q7TQN4 309165 1q43 rat K310-ac 459096 KRTYETFkSIMKKSP molecular association, regulation; intracellular localization transcription, induced DNA(INDUCES) 22044919; 26298192; 31073968 84 5 0 BACE1 protein and its activity was increased and localized in neurites, after exposure to PA; increase in K310 acetylation due to inhibition of SIRT1 +DSN1 DSN1 Cell cycle regulation Q9H410 79980 20q11.23 human S331-p 10800768 SMQQLDPsPARKLLK MIS13 molecular association, regulation SPC25(DISRUPTS); SPBC24(DISRUPTS) 30420662 1 19 1 Fluorescence polarization, decreased affinity of the interaction +Dusp29 DUSP29 EC 3.1.3.16; EC 3.1.3.48; PHOSPHATASE; Protein phosphatase, dual-specificity P0C595 361003 rat T155-p 18122802 MGRSRSAtLVLAYLM DSPc enzymatic activity, inhibited 21199871 1 0 0 +PAK5 PAK5 EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, STE; Protein kinase, Ser/Thr (non-receptor) Q9P286 57144 20p12.2 human S573-p 11327000 HRDIKSDsILLTSDG Pkinase cytoskeletal reorganization 11756552 1 0 0 +GFAP GFAP Cytoskeletal P14136 2670 17q21.31 human S17-p 1868071202 ARRSYVSsGEMMVGG Filament_head protein stabilization 12177195 1 1 0 +RUNX1 AML1 DNA-binding; Oncoprotein; Transcription factor Q01196 861 21q22.12 human K83-ub 41481876 PTHWRCNkTLPIAFK Runt protein degradation; intracellular localization carcinogenesis, inhibited; cell growth, inhibited; transcription, induced; transcription, inhibited DNA(INDUCES) 11830488; 28536267 2 3 0 +NCAPD3 NCAPD3 Cell cycle regulation P42695 23310 11q25 human S1419-p 19009802 AISTPEKsISDVTFG cell cycle regulation 21498573 1 0 0 +OPRL1 KOR-3 GPCR, family 1; Membrane protein, integral; Membrane protein, multi-pass; Receptor, GPCR P41146 4987 20q13.33 human S351-p 1868135701 QVSDRVRsIAKDVAL receptor internalization, induced; receptor desensitization, induced signaling pathway regulation 30914485 2 0 0 +IGFBP3 IGFBP3 Cell development/differentiation; Secreted; Secreted, signal peptide P17936 3486 7p12.3 human S138-p 451462 PPAPGNAsESEEDRS apoptosis, induced 12210764 3 0 0 +PPP2R2B PPP2R2B iso2 Apoptosis; Mitochondrial; Motility/polarity/chemotaxis; Protein phosphatase, regulatory subunit Q00005-2 5521 5q32 human S21-p 25554901 PPNTILSsSCHTEAD intracellular localization; phosphorylation apoptosis, inhibited 22583914 1 0 0 induces phosphorylation of Drp1 and regulates mitochondrial fragmentation and OMM translocation of beta B2 +IRAK1 IRAK1 EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, Ser/Thr (non-receptor); Protein kinase, TKL P51617 3654 Xq28 human S376-p 449756 GSSPSQSsMVARTQT Pkinase enzymatic activity, induced 29208712 2 1 1 +CAP1 CAP1 Actin-binding; Cytoskeletal Q01518 10487 1p34.2 human S310-p 2525971 PKPQTSPsPKRATKK activity, induced carcinogenesis, induced; cell motility, induced; cell growth, induced; cell adhesion, induced; apoptosis, inhibited; transcription, induced; cytoskeletal reorganization 30123351; 30894654; 34636991 5 47 6 +Card11 CARD11 Adaptor/scaffold Q8CIS0 108723 5|5 G2 mouse S567-p 457640 RSRSSIMsITAEPPG enzymatic activity, induced signaling pathway regulation 31391255 5 0 0 antigen receptor signaling +CCAR1 CCAR1 Apoptosis; Nuclear receptor co-regulator; RNA splicing Q8IX12 55749 10q21.3 human T667-p 4759590 SQLIARLtKQLKVEE SAP molecular association, regulation cell growth, inhibited; apoptosis, induced TAZ(INDUCES) 20594350 1 1 0 +UPF1 RENT1 iso2 C2H2-type zinc finger protein; EC 3.6.1.-; EC 3.6.4.-; Hydrolase; RNA-binding Q92900-2 5976 19p13.11 human S1116-p 460825 HGGVTGLsQY_____ molecular association, regulation RNA(INDUCES) 25184677 3 31 51 marker for cellular NMD targets +NTRK3 TrkC EC 2.7.10.1; KINASE; Kinase, protein; Membrane protein, integral; Protein kinase, TK; Protein kinase, tyrosine (receptor) Q16288 4916 15q25.3 human Y516-p 450003 PVIENPQyFRQGHNC cell growth, altered 11877382 2 5 66 +Slc4a4 SLC4A4 Membrane protein, integral; Membrane protein, multi-pass; Transporter; Transporter, SLC family O88343 54403 5|5 E1 mouse S245-p 2047937 FSNPDNGsPAMTHRN Band_3_cyto activity, inhibited 34642952 1 25 25 +SPRY2 SPRY2 Adaptor/scaffold; Inhibitor; Motility/polarity/chemotaxis O43597 10253 13q31.1 human Y227-p 455228 CCVKGLFyHCSNDDE Sprouty activity, inhibited; phosphorylation transcription, altered 15637081 1 0 0 +PLIN1 perilipin 1 Lipid-binding O60240 5346 15q26.1 human S497-p 459628 EKPKRRVsDSFFRPS intracellular localization 29688805 12 12 0 adrenergic control of lipolysis ; OPA1 is indispensable for HSL translocation to LDs and its phosphorylation on S650 and S552 +Mknk2 Mnk2 EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, CAMK; Protein kinase, Ser/Thr (non-receptor); Translation Q8CDB0 17347 10|10 C1 mouse T249-p 447641 ISTPELLtPCGSAEY Pkinase enzymatic activity, induced 11154262 1 1 0 +SLC9A5 NHE5 Membrane protein, integral; Membrane protein, multi-pass; Transporter; Transporter, SLC family Q14940 6553 16q22.1 human S575-p 34424900 VTNLLREsGSGACLD activity, induced; intracellular localization 24936055 1 0 0 accumulation at the cell surface to regulate cytoplasmic pH; metabolic stress-induced activation +BRCA1 BRCA1 EC 6.3.2.-; Nuclear receptor co-regulator; Transcription, coactivator/corepressor; Tumor suppressor; UBIQUITIN LIGASE; Ubiquitin conjugating system; Ubiquitin ligase P38398 672 17q21.31 human S988-p 448526 PPLFPIKsFVKTKCK activity, induced; intracellular localization carcinogenesis, induced; DNA repair, induced; apoptosis, inhibited 10724175; 12427729; 14701743; 18987440; 33397362 10 0 0 +Max MAX DNA-binding; Transcription factor P52164 60661 6q24 rat S11-p 449308 NDDIEVEsDEEQPRF molecular association, regulation DNA(NOT_REPORTED) 8247525 5 28 0 increases both the on- and off-rates for DNA binding +EML4 EML4 Cytoskeletal Q9HC35 27436 2p21 human S144-p 465781 QSPQIRAsPSPQPSS molecular association, regulation cell cycle regulation; cytoskeletal reorganization TUBB1(INDUCES); TUBA1A(INDUCES) 31409757 1 52 9 +Cycs CYCS Apoptosis; Mitochondrial; Oxidoreductase; PHOSPHATASE; Protein phosphatase, Ser/Thr (non-receptor) P62898 25309 4q24 rat T59-p 36622721 ANKNKGItWGEDTLM Cytochrom_C protein conformation apoptosis, inhibited 31676852 1 4 0 +Gabrg2 GABRG2 Channel, chloride; Channel, ligand-gated; Membrane protein, integral; Membrane protein, multi-pass; Transporter; Transporter, ion channel P22723 14406 11 A5|11 24.8 cM mouse K373-ub 11956710 KDKDKKKkNPLLRMF Neur_chan_memb protein degradation; receptor internalization, altered 19815531 1 0 0 regulation of the late endosomal/lysosomal trafficking of GABA receptors, regulation of synaptic transmission +Mst1r Ron EC 2.7.10.1; KINASE; Kinase, protein; Membrane protein, integral; Protein kinase, TK; Protein kinase, tyrosine (receptor) Q62190 19882 9 59.07 cM|9 F1 mouse Y1294-p 456484 EYCPDSLyHVMLRCW PK_Tyr_Ser-Thr enzymatic activity, induced Src(NOT_REPORTED) 16103119 2 0 0 this site is responsible for constitutive activation of the MAP kinase pathway +Nr3c1 GR DNA-binding; Mitochondrial; Nuclear receptor; Transcription factor P06536 24413 18p11 rat S224-p 447967 DLEFSAGsPSKDTNE GCR intracellular localization 25330740 20 7 0 +VHL VHL Tumor suppressor; UBIQUITIN LIGASE; Ubiquitin ligase P40337 7428 3p25.3 human S111-p 22516600 GTGRRIHsYRGHLWL VHL molecular association, regulation cell cycle regulation; carcinogenesis, inhibited; apoptosis, induced; transcription, induced Tip60(INDUCES); p300(INDUCES) 22071692 1 0 1 positive regulator of p53; initiates transcription on p53 target gene promoters in response to DNA damage; tumor suppresor; required for p53-dependent cell cycle arrest and apoptosis +Stx1a STX1A Membrane protein, integral; Vesicle P32851 116470 12q12 rat T23-p 27909086 DDDDVTVtVDRDRFM endocytosis, altered; exocytosis, induced 33582301 1 1 0 +NHERF1 NHERF Adaptor/scaffold; Motility/polarity/chemotaxis O14745 9368 17q25.1 human S339-p 455752 ERAHQKRsSKRAPQM EBP50_C molecular association, regulation CFTR(INDUCES); Ezrin(DISRUPTS) 17613530; 35140182 5 1 18 +SATB1 SATB1 DNA-binding; Transcription factor Q01826 6304 3p24.3 human K744-sm 2293715 TNTLFSVkLEEELSV protein degradation; intracellular localization apoptosis, induced 18408014 2 1 0 +Traf2 TRAF2 Autophagy; EC 6.3.2.-; Ligase; UBIQUITIN LIGASE; Ubiquitin conjugating system; Ubiquitin ligase P39429 22030 2|2 A3 mouse K31-ub 486266 LGTRLEAkYLCSACK protein degradation; molecular association, regulation; phosphorylation transcription, induced TAB2(INDUCES) 11909853; 19150425 2 1 0 induces IKB phosphorylation +SOD2 SOD2 EC 1.15.1.1; Mitochondrial; Oxidoreductase P04179 6648 6q25.3 human R197-m2 1872904404 YLQYKNVrPDYLKAI Sod_Fe_C cell cycle regulation 22710435 1 1 0 quiescent fibroblasts are dimethylated at K122, and R197 and are also dimethylated in proliferating cells +Nlrp3 NLRP3 Inhibitor Q8R4B8 216799 11|11 B1.3 mouse Y132-p 1869022700 ICKKKKDyCKMYRRH activity, inhibited 32352641 1 0 0 inhibits inflammasome assembly +CIC capicua DNA-binding; Transcription factor Q96RK0 23152 19q13.2 human S1389-p 4952030 SPRAILGsYRKKRKN molecular association, regulation; intracellular localization KPNA3(DISRUPTS) 21087211 1 6 0 +PDCD1 PD-1 Apoptosis; Membrane protein, integral Q15116 5133 2q37.3 human Y248-p 50293001 CVPEQTEyATIVFPS molecular association, regulation SHP-2(INDUCES); SHP-1(INDUCES) 15240681 4 0 0 +PTK2 FAK EC 2.7.10.2; KINASE; Kinase, protein; Protein kinase, TK; Protein kinase, tyrosine (non-receptor) Q00944 396416 chicken Y576-p 447889 RYMEDSTyYKASKGK PK_Tyr_Ser-Thr activity, induced; phosphorylation; enzymatic activity, induced 12370821; 9790958 95 65 2523 +ARHGEF1 ARHGEF1 GEF; GEF, Rac/Rho; Motility/polarity/chemotaxis Q92888 9138 19q13.2 human S240-p 4936516 TKSGDKKsGRNFFRK activity, induced transcription, induced; signaling pathway regulation 32881857 1 0 6 regulates RhoA activation and signaling +HDC HDC Amino Acid Metabolism - histidine; EC 4.1.1.22; Lyase P19113 3067 15q21.2 human S195-p 1884002000 YASDQAHsSVEKAGL enzymatic activity, induced 37651872 1 0 0 +EDC3 EDC3 RNA processing Q96F86 80153 15q24.1 human S161-p 1211074 SFRRRHNsWSSSSRH Edc3_linker molecular association, regulation 14-3-3 beta(INDUCES) 20051463 1 36 341 +Crebbp CBP ACETYLTRANSFERASE; Acetyltransferase; DNA-binding; EC 2.3.1.48; Motility/polarity/chemotaxis; Nuclear receptor co-regulator; Transcription, coactivator/corepressor P45481 12914 16 A1|16 2.4 cM mouse S436-p 447689 CLPLKNAsDKRNQQT molecular association, regulation cell differentiation, altered; transcription, induced; transcription, altered; cell growth, altered CREB(DISRUPTS) 11463380; 16908541; 20152182 5 0 0 +Slc12a1 NKCC2 Membrane protein, integral; Membrane protein, multi-pass; Transporter; Transporter, SLC family P55016 25065 3q36 rat T114-p 459122 KIEYYRNtGSVSGPK AA_permease_N activity, induced; molecular association, regulation ANXA2(DISRUPTS) 18550832; 24526686 4 2 0 Low chloride hypotonic stress enhances raft association of NKCC2 and AnxA2; observed in triple mutant T96/111/101A +Lpin1 LPIN1 EC 3.1.3.4; Phosphatase, lipid Q91ZP3 14245 12 A1.1|12 7.9 cM mouse K599-sm 10902806 RGRNATIkEESKPEQ intracellular localization transcription, induced 19753306 1 0 0 +YBX1 YB-1 RNA processing; RNA splicing; RNA-binding; Transcription factor P67809 4904 1p34.2 human K304-ub 3934716 PQDGKETkAADPPAE RNA stability, inhibited 35273154 1 5 64 SIAH1-mediated YBX-1 ubiquitination, which leads to accelerated mRNA degradation which could be important for chemosensitization in epithelial ovarian cancer (EOC) +FOXM1 FOXM1 iso2 DNA-binding; Transcription factor Q08050-2 2305 12p13.33 human S251-p 10897608 MIQFAINsTERKRMT Forkhead molecular association, regulation; phosphorylation cell cycle regulation; transcription, induced CBP(INDUCES) 19737929 1 1 0 increases phosphorylation of FOXM1 T596 by CDK1 in vivo and in vitro +Irs1 IRS1 Adaptor/scaffold; Motility/polarity/chemotaxis P35569 16367 1 C5|1 42.0 cM mouse S318-p 451399 MVGGKPGsFRVRASS phosphorylation 16418171 12 17 3 Phosphorylation of S318 leads to an increase of phospho-Ser473 Akt1 in L6GLUT4 myotubes. +Cdc25a CDC25A EC 3.1.3.48; Motility/polarity/chemotaxis; PHOSPHATASE; Protein phosphatase, dual-specificity P48964 12530 9 F2|9 59.81 cM mouse S123-p 449127 PALKRSHsDSLDHDT M-inducer_phosp protein degradation; intracellular localization cell cycle regulation; apoptosis, altered; cytoskeletal reorganization 15928203; 18936171 7 1 0 centrosome amplification and colocalization with Cdc25A in S122A mutant cells +Drd1 DRD1 GPCR, family 1; Membrane protein, integral; Membrane protein, multi-pass; Receptor, GPCR P18901 24316 17p14 rat T428-p 458339 SVILDYDtDVSLEKI receptor desensitization, altered; intracellular localization 16338988 2 0 0 +FPR2 FPR2 GPCR, family 1; Membrane protein, integral; Membrane protein, multi-pass; Motility/polarity/chemotaxis; Receptor, GPCR P25090 2358 19q13.41 human Y302-p 3176600 SCLNPMLyVFVGQDF 7tm_1; TM receptor desensitization, altered 11063592 1 0 0 downregulates PLD activation +BLM BLM DNA repair, damage; DNA replication; EC 3.6.4.12; Helicase P54132 641 15q26.1 human K105-ub 28132100 ETQRGGSkSLLPDFL BLM_N molecular association, regulation; intracellular localization DNA repair, inhibited RAP80(INDUCES) 23708797 1 2 0 +MAPT Tau iso8 ACETYLTRANSFERASE; Acetyltransferase; Cytoskeletal P10636-8 4137 17q21.31 human S324-p 449328 KVTSKCGsLGNIHHK Tubulin-binding molecular association, regulation cytoskeletal reorganization 10090741; 21204788; 28760828 12 8 2 impaired capacity to drive microtubule assembly +AURKB AurB EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, Other; Protein kinase, Ser/Thr (non-receptor) Q96GD4 9212 17p13.1 human S227-p 4271812 GWSVHAPsLRRKTMC Pkinase molecular association, regulation; intracellular localization; phosphorylation cell cycle regulation 14-3-3 zeta(DISRUPTS) 28004745; 34143863 2 7 4 C1A and C1B domains are necessary for localization, and inter-C1 domain (IC1D) domains for retention at the midbody, S350 dephosphorylation is necessary for 14-3-3 complex assembly, and for Aurora B S227 phosphorylation at the midbody; substrate specificity; abscission, cytokinesis +UGT1A3 UGT1A3 Carbohydrate Metabolism - ascorbate and aldarate; Carbohydrate Metabolism - pentose and glucuronate interconversions; Carbohydrate Metabolism - starch and sucrose; Cofactor and Vitamin Metabolism - porphyrin and chlorophyll; Cofactor and Vitamin Metabolism - retinol; EC 2.4.1.17; Lipid Metabolism - androgen and estrogen; Membrane protein, integral; Transferase; Xenobiotic Metabolism - drug metabolism - cytochrome P450; Xenobiotic Metabolism - drug metabolism - other enzymes; Xenobiotic Metabolism - metabolism by cytochrome P450 P35503 54659 2q37.1 human S43-p 34357665 IDGSHWLsMREVLRE UDPGT enzymatic activity, induced 26094731 1 0 1 +CTTN Cortactin Actin-binding; Cytoskeletal; Motility/polarity/chemotaxis Q14247 2017 11q13.3 human S405-p 447700 KTQTPPVsPAPQPTE protein degradation; molecular association, regulation; ubiquitination; protein conformation carcinogenesis, altered; endocytosis, altered; cell motility, induced; cell motility, altered; cell motility, inhibited; cytoskeletal reorganization; cell adhesion, altered N-WASP(INDUCES); WAVE2(INDUCES) 20444238; 21079800; 21856159; 24188565; 24265417; 24867096; 26490115 18 87 128 +Gria2 GluR2 Channel, calcium; Channel, ligand-gated; Membrane protein, integral; Membrane protein, multi-pass P19491 29627 2q33 rat Y873-p 35547400 FATYKEGyNVYGIES receptor internalization, induced 14976558 2 0 0 long-term depression of AMPA receptor-mediated excitatory postsynaptic currents +Crtc2 TORC2 Transcription, coactivator/corepressor Q3U182 74343 3|3 F1 mouse S369-p 454651 PQLQGSHsHPSLPAS molecular association, regulation 14-3-3 beta(INDUCES) 18626018 2 1 6 +Trp53bp1 53BP1 DNA repair, damage; Transcription, coactivator/corepressor P70399 27223 2|2 E5 mouse S382-p 452380 TPFIVPSsPTEQGGR molecular association, regulation cell cycle regulation PLK1(INDUCES) 20126263 3 59 6 +GGA1 GGA1 Adaptor/scaffold; Vesicle Q9UJY5 26088 22q13.1 human S355-p 455525 EQPSASVsLLDDELM molecular association, regulation; activity, inhibited IGF2R(DISRUPTS) 12060753 4 0 0 +NUDC NUDC Cell cycle regulation; Cytoskeletal Q9Y266 10726 1p36.11 human K39-ac 31068003 FFSFLRRkTDFFIGG Nudc_N cell cycle regulation 24069238 1 1 0 +H2AZ1 H2AZ DNA-binding P0C0S5 3015 4q23 human K13-ac 466365 GKDSGKAkTKAVSRS Histone molecular association, regulation transcription, induced FALZ(INDUCES) 32356653 2 6 292 K7ac preferentially engaging the binding site, acetylation at K7ac and K13ac is also the highest-affinity acetylation pattern of isoform I +EZH2 EZH2 iso2 EC 2.1.1.43; METHYLTRANSFERASE; Methyltransferase; Methyltransferase, protein lysine Q15910-2 2146 7q36.1 human S734-p 29606713 LFFDYRYsQADALKY protein degradation; molecular association, regulation cell cycle regulation; DNA repair, induced SUZ12(DISRUPTS); EED(DISRUPTS) 24162653 1 0 0 +ARHGAP25 ARHGAP25 GAP; GAP, Rac/Rho P42331 9938 2p13.3 human S487-p 3951314 EGHRRTMsQDLRQLS activity, inhibited 36190314 1 12 5 +PKM PKM iso2 Carbohydrate Metabolism - glycolysis and gluconeogenesis; Carbohydrate Metabolism - pyruvate; EC 2.7.1.40; KINASE; Kinase, other; Mitochondrial; Nucleotide Metabolism - purine P14618-2 5315 15q23 human T365-p 31886917 CIMLSGEtAKGDYPL PK enzymatic activity, induced apoptosis, induced 26258887 1 1 1 +LILRB2 LILRB2 Membrane protein, integral; Receptor, misc. Q8N423 10288 19q13.42 human Y532-p 451318 DAQEENLyAAVKDTQ molecular association, regulation; phosphorylation CSK(INDUCES); SHP-1(INDUCES) 11907092; 15474475 2 3 11 Mutation of Y533 prevented binding in vivo. ; necessary for serotonin release; tyrosine phosphorylation of ILT2 +TSC2 TSC2 Cell cycle regulation; GAP; GAP, misc.; Nuclear receptor co-regulator; Tumor suppressor P49815 7249 16p13.3 human S1387-p 450212 QPLSKSSsSPELQTL phosphorylation carcinogenesis, inhibited; autophagy, induced; cell growth, inhibited; cell growth, induced; transcription, inhibited; signaling pathway regulation 20363874; 33271062; 34247189; 35670018 19 14 6 +TP73 p73 DNA-binding; Transcription factor; Tumor suppressor O15350 7161 1p36.32 human S426-p 33602702 GGMNKLPsVNQLVGQ intracellular localization 24874608 1 0 0 nuclear localization +VIM Vimentin Cytoskeletal; Motility/polarity/chemotaxis P08670 7431 10p13 human S9-p 455450 STRSVSSsSYRRMFG Filament_head cell motility, altered 19291697 4 4 3 +Naca NACA Motility/polarity/chemotaxis; Transcription, coactivator/corepressor P70670 17938 10|10 D3 mouse S2015-p 454238 PELEEQDsTQTATQQ intracellular localization transcription, altered 19884350 2 1 0 regulates expression of osteocalcin and COL1A1 +TPH2 TPH2 Amino Acid Metabolism - tryptophan; EC 1.14.16.4; Oxidoreductase Q8IWU9 121278 12q21.1 human S19-p 470085 YWARRGFsLDSAVPE protein stabilization; molecular association, regulation; enzymatic activity, induced 14-3-3 beta(INDUCES); 14-3-3 epsilon(INDUCES); 14-3-3 gamma(INDUCES) 15663479; 17973628; 18339632 5 5 2 modulates serotonin production +MST1R Ron EC 2.7.10.1; KINASE; Kinase, protein; Membrane protein, integral; Protein kinase, TK; Protein kinase, tyrosine (receptor) Q04912 4486 3p21.31 human Y1360-p 456488 YVQLPATyMNLGPST molecular association, regulation; phosphorylation cell growth, altered Met(INDUCES) 10871856; 11064459 5 0 0 +VCPIP1 VCIP135 Cell cycle regulation; DEUBIQUITINASE; EC 3.4.19.12; Protease; Ubiquitin conjugating system; Ubiquitin-specific protease Q96JH7 80124 8q13.1 human T761-p 472123 GPSSAPAtPTKAPYS molecular association, regulation cell cycle regulation VCP(DISRUPTS) 23500464 1 16 25 Golgi disassembly at mitosis, inhibits membrane fusion +KIT Kit EC 2.7.10.1; KINASE; Kinase, protein; Membrane protein, integral; Oncoprotein; Protein kinase, TK; Protein kinase, tyrosine (receptor) P10721 3815 4q12 human Y547-p 13876400 VMILTYKyLQKPMYE enzymatic activity, induced 20147452 1 1 0 +TLR7 TLR7 Membrane protein, integral Q9NYK1 51284 Xp22.2 human Y1024-p 1875831802 TNPQAHPyFWQCLKN TIR ubiquitination; intracellular localization; phosphorylation transcription, inhibited; signaling pathway regulation 34936223 1 0 0 inhibits ubiquitination of itself, regulates NF-kB phosphorylation and TLR7/NF-kB signaling +EYA1 EYA1 Apoptosis; Cell development/differentiation; DNA repair, damage; EC 3.1.3.16; EC 3.1.3.48; Motility/polarity/chemotaxis; PHOSPHATASE; Protein phosphatase, tyrosine (non-receptor) Q99502 2138 8q13.3 human K43-sm 41156502 TPNGTEVkTEPMSSS transcription, inhibited 24954506 1 0 0 +Kcnj5 GIRK4 Channel, potassium; Membrane protein, integral; Membrane protein, multi-pass P48548 29713 8q21 rat Y32-p 3146604 IPKQARDyIPIATDR activity, inhibited 10833508 1 0 0 +Cebpb C/EBP-beta DNA-binding; Motility/polarity/chemotaxis; Transcription factor P28033 12608 2 H3|2 87.58 cM mouse K117-ac 473551 SLGRAGAkAAPPACF transcription, induced 17110376 1 0 0 increased activation of C/EBP-beta promoter +Drd1 DRD1 GPCR, family 1; Membrane protein, integral; Membrane protein, multi-pass; Receptor, GPCR P18901 24316 17p14 rat S259-p 455303 ECAQSESsFKMSFKR 7tm_1 receptor desensitization, altered 14660631 2 0 0 +MYLK smMLCK EC 2.7.11.18; KINASE; Kinase, protein; Protein kinase, CAMK; Protein kinase, Ser/Thr (non-receptor) Q15746 4638 3q21.1 human S947-p 4739853 EEERKVHsPQQVDFR molecular association, regulation; intracellular localization ACTN1(INDUCES) 34302892 1 12 1 +CACNA1D CACNA1D Channel, calcium; Membrane protein, integral; Membrane protein, multi-pass Q01668 776 3p21.1 human S1490-p 465731 DEFKRIWsEYDPEAK GPHH activity, induced 16763033 1 2 0 required for IGF-1 induced channel potentiation +Nos1 nNOS Amino Acid Metabolism - arginine and proline; EC 1.14.13.39; Oxidoreductase P29476 24598 12q16 rat K1300-ac 2459101 REETLQAkNKGVFRE NAD_binding_1 activity, induced 18415985 1 0 0 +KHDRBS1 KHDRBS1 RNA-binding Q07666 10657 1p35.2 human T317-p 18504947 RGALVRGtPVRGAIT molecular association, regulation; intracellular localization cell cycle regulation; RNA splicing, inhibited; cell growth, induced; apoptosis, inhibited RNA(DISRUPTS) 36537190 1 4 1 +PROX1 PROX1 DNA-binding; Nuclear receptor co-regulator; Transcription factor Q92786 5629 1q32.3 human S79-p 487308 KLLKRANsYEDAMMP protein degradation; molecular association, regulation; ubiquitination carcinogenesis, inhibited; cell growth, inhibited; transcription, induced; signaling pathway regulation DDB1(INDUCES) 36433955 1 10 6 regulates mTOR signaling +WIPF1 WIPF1 Actin-binding; Motility/polarity/chemotaxis O43516 7456 2q31.1 human S488-p 449880 RNESRSGsNRRERGA molecular association, regulation; protein conformation cytoskeletal reorganization WASP(DISRUPTS) 12504004; 24962707 5 0 0 reduces the stability and enhances the mobility of WIP and WASp clusters +TAB1 TAB1 Activator; Motility/polarity/chemotaxis Q15750 10454 22q13.1 human S456-p 22869802 HTQSSSSsSDGGLFR intracellular localization; phosphorylation; enzymatic activity, induced transcription, inhibited 22216226 1 0 0 TAB1 induce p38 MAPK phosphorylation and mRNA destabilization, induces p38 MAPK activation. TAB1 and p38MAPK mutually control eachother's phosphorylation status, activity and intracellular localization. +PTGER4 PTGER4 GPCR, family 1; Membrane protein, integral; Membrane protein, multi-pass; Receptor, GPCR P35408 5734 5p13.1 human S379-p 450697 AMSGHSRsFISRELK molecular association, regulation ARRB1(INDUCES) 14709160 1 0 0 +Tgfb1i1 Hic-5 Motility/polarity/chemotaxis; Nuclear receptor co-regulator; Transcription, coactivator/corepressor Q62219 21804 7|7 F3 mouse Y38-p 456816 TLTPPPPyGHQPQTG cytoskeletal reorganization 16183059 1 1 2 phosphorylation of this site after EGF induction leads to reduction of Rac activity and formation of lamellipodia +CFL1 Cofilin-1 Cytoskeletal; Motility/polarity/chemotaxis; Nuclear receptor co-regulator P23528 1072 11q13.1 human S23-p 9218412 NDMKVRKsSTPEEVK Cofilin_ADF molecular association, regulation cytoskeletal reorganization 14-3-3 zeta(INDUCES) 22855535 1 4 1 inhibition of depolymerization of actin, cessation of degranulation +DDX5 DDX5 EC 3.6.4.13; Helicase; Nuclear receptor co-regulator; Nucleolus; RNA splicing; RNA-binding; Spliceosome P17844 1655 17q23.3 human Y595-p 478485 MNQQAYAyPATAAAP apoptosis, inhibited 17384675 1 1 0 +BLM BLM DNA repair, damage; DNA replication; EC 3.6.4.12; Helicase P54132 641 15q26.1 human S646-p 15349300 LKHERFQsLSFPHTK BDHCT_assoc molecular association, regulation; intracellular localization PML(INDUCES); NCL(INDUCES) 20719863 1 1 0 +Gorasp2 GRASP55 Motility/polarity/chemotaxis; Vesicle Q9R064 113961 3q22 rat T222-p 470124 LPGQMTGtPITPLKD molecular association, regulation cytoskeletal reorganization GRASP55(DISRUPTS) 20083603 2 33 4 inhibits Golgi stack formation in interphase cells and enhances Golgi fragmentation in mitotic cells +Lats1 LATS1 EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, AGC; Protein kinase, Ser/Thr (non-receptor); Tumor suppressor Q8BYR2 16798 10|10 A1 mouse Y200-p 1876860400 SLGENVVyRSESPNS phosphorylation; enzymatic activity, induced cell growth, inhibited; transcription, induced; signaling pathway regulation 35394840 1 1 0 +METTL1 METTL1 EC 2.1.1.33; METHYLTRANSFERASE; Methyltransferase; RNA processing Q9UBP6 4234 12q14.1 human S27-p 3627513 YYRQRAHsNPMADHT enzymatic activity, inhibited; protein conformation 15861136; 25233213; 36599985 3 23 66 +FCGR2B FCGR2B Cell surface; Membrane protein, integral; Oncoprotein P31994 2213 1q23.3 human Y292-p 448507 GAENTITySLLMHPD molecular association, regulation SHP-2(INDUCES) 10704309 4 2 1 +MYC Myc DNA-binding; Nucleolus; Oncoprotein; Transcription factor P01106 4609 8q24.21 human K407-sm 40724411 ENNEKAPkVVILKKA HLH protein degradation; ubiquitination transcription, inhibited 25895136 1 2 0 +Ppargc1b PGC-1 beta Nuclear receptor co-regulator; Transcription, coactivator/corepressor Q8VHJ7 170826 18|18 E1 mouse K202-ac 7761203 VDGTQDKkTPTLRAQ intracellular localization transcription, inhibited 19491097 1 1 0 +PTGER4 PTGER4 GPCR, family 1; Membrane protein, integral; Membrane protein, multi-pass; Receptor, GPCR P35408 5734 5p13.1 human S374-p 450695 QRTSSAMsGHSRSFI molecular association, regulation ARRB1(INDUCES) 14709160 1 0 1 +UBA52-RPS27A-UBB-UBC ubiquitin Ubiquitin-like modifier P62988 2p16 human K48-ac 459086 QRLIFAGkQLEDGRT ubiquitin protein degradation; molecular association, regulation; ubiquitination UBE2V1(INDUCES) 2160452; 25527407 6 6 0 inhibits polyubiquitin chain elongation; substrate degradation in ubiquitin mediated proteolysis +Slc1a2 GLT1 Membrane protein, integral; Membrane protein, multi-pass; Transporter; Transporter, SLC family P31596 29482 3q32 rat S563-p 486052 NGKSADCsVEEEPWK intracellular localization; activity, inhibited 34516830 1 6 0 +Klf1 KLF1 C2H2-type zinc finger protein; DNA-binding; Transcription factor P46099 16596 8 41.3 cM|8 C3 mouse K270-ac 460630 SRRTLAPkRQAAHTC cell differentiation, induced; transcription, induced 12920040 3 0 0 +Crtc3 TORC3 Transcription, coactivator/corepressor Q91X84 70461 7|7 D3 mouse S370-p 1210886 SLRLFSLsNPSLSTT molecular association, regulation; activity, inhibited transcription, inhibited 14-3-3 beta(INDUCES) 23033494; 25114223 2 41 47 inhibits nuclear localization; Dasatinib and bosutinib induce IL-10 production and induced transcription +Pip5k1b PIP5K1B Carbohydrate Metabolism - inositol phosphate; EC 2.7.1.68; Kinase, lipid P70181 18719 19|19 B mouse S413-p 27461455 PSKKRCNsIAALKAT enzymatic activity, inhibited 23909401 1 5 0 +TAB3 TAB3 Adaptor/scaffold Q8N5C8 257397 Xp21.2 human S408-gl 54400803 TATTPPSsSPSRGIS cell motility, induced 27009840 1 2 0 induced cell migration and invasion +GIT1 GIT1 GAP; GAP, ARF; Motility/polarity/chemotaxis Q9Y2X7 28964 17q11.2 human Y321-p 15702200 FLPVNPEySATRNQG molecular association, regulation; intracellular localization cell motility, induced; cell adhesion, altered FAK(INDUCES) 22302306 4 0 0 GIT1 Y321 is necessary for FAK activation localization at focal adhesions +Slc12a5 KCC2 Membrane protein, integral; Membrane protein, multi-pass; Transporter; Transporter, SLC family Q91V14 57138 2|2 H3 mouse Y926-p 14932400 SDISAYTyEKTLVME SLC12 protein degradation 20600929 1 0 0 decreases the cell surface stability of SLC12A5 (aka KCC2) +TARDBP TDP-43 RNA-binding Q13148 23435 1p36.22 human Y155-p 464438 GFVRFTEyETQVKVM RRM_1 molecular association, regulation; intracellular localization RNA(DISRUPTS) 28167528 1 1 15 nuclear recruitment, decrease RNA binding affinity (fluorescence-based RNA binding assay, regulation of splicing +RELA NFkB-p65 DNA-binding; Nuclear receptor co-regulator; Transcription factor Q04206 5970 11q13.1 human S536-p 447800 SGDEDFSsIADMDFS protein degradation; acetylation; molecular association, regulation; protein stabilization; phosphorylation; activity, induced; ubiquitination; intracellular localization cell cycle regulation; carcinogenesis, induced; apoptosis, altered; apoptosis, induced; cell motility, induced; RNA stability, induced; RNA stability, inhibited; signaling pathway regulation; cell growth, induced; cell motility, altered; transcription, inhibited; cell growth, altered; carcinogenesis, altered; transcription, induced; transcription, altered; endocytosis, induced; cell differentiation, induced; apoptosis, inhibited TAFII31(INDUCES); CDK5RAP3(DISRUPTS); PPP2CA(DISRUPTS) DNA(INDUCES); DNA(DISRUPTS) 10521409; 11259436; 12419817; 12767944; 12842894; 14963024; 15100319; 15128824; 15192014; 15489227; 15849198; 16105840; 16148147; 16163708; 16407239; 16840782; 17409387; 17595324; 17785205; 18453612; 19073147; 20224721; 20507904; 20696864; 20961594; 21177808; 21816815; 24442433; 25136068; 26082493; 26170389; 26307684; 26693062; 26729520; 26826124; 27244888; 27528614; 27555662; 28122346; 28416608; 31980577; 32123095; 33459422; 33578126; 33579825; 33762327; 33789981; 33883226; 33914760; 33941613; 33971703; 34017102; 34082140; 34219129; 34380537; 34588619; 34785213; 35197571; 35588785; 36048884; 36116131; 36264688; 36460775; 36931391; 37450351 254 4 0 +MYF5 Myf-5 DNA-binding; Transcription factor P13349 4617 12q21.31 human S133-p 457385 NAIRYIEsLQELLRE HLH activity, induced 9461343 1 0 0 +Nefl NFL Cytoskeletal P08551 18039 14|14 D1 mouse S50-p 457403 YSAPVSSsLSVRRSY Filament_head molecular association, regulation; intracellular localization 14-3-3 gamma(INDUCES) 23230147 2 0 0 regulates NF-L dynamic exchange rate and neurofilament disassembly +Lrp6 LRP6 Membrane protein, integral; Receptor, misc. O88572 16974 6 G1|6 65.37 cM mouse S1607-p 21241903 HLYPPPPsPCTDSS_ signaling pathway regulation 24692544 2 1 0 Wnt signaling +YAP1 YAP1 Oncoprotein; Transcription, coactivator/corepressor P46937 10413 11q22.1 human T119-p 4959542 AGTAGALtPQHVRAH cell cycle regulation; carcinogenesis, induced; cell motility, induced; cytoskeletal reorganization 24101154 4 25 111 +APP APP Apoptosis; Cell surface; Membrane protein, integral; Receptor, misc.; Transcription factor P05067 351 21q21.3 human T743-p 448523 VEVDAAVtPEERHLS APP_amyloid protein stabilization; molecular association, regulation; intracellular localization cell cycle regulation; transcription, induced; cell growth, altered Abl(INDUCES); Src(INDUCES); DAB1(INDUCES); PLCG2(INDUCES); APPBP1(INDUCES); SHC3(INDUCES); SHC1(INDUCES); GRB2(INDUCES); GRB7(INDUCES); PLCG1(INDUCES); Fe65(INDUCES); PIN1(INDUCES); SHC2(INDUCES); LYN(INDUCES); NCK1(INDUCES); CRK(INDUCES) 14722157; 17634293; 19602287; 21151996; 28720718 39 5 3 dopaminergic (DA) neurodegeneration +Runx1 AML1 DNA-binding; Oncoprotein; Transcription factor Q03347 12394 16 C4|16 53.7 cM mouse Y379-p 51211401 SPSYHLYyGASAGSY RunxI activity, induced; protein stabilization transcription, induced HDAC1(DISRUPTS) DNA(INDUCES) 26598521 1 0 0 +RAF1 RAF1 EC 2.7.11.1; KINASE; Kinase, protein; Oncoprotein; Protein kinase, Ser/Thr (non-receptor); Protein kinase, TKL P04049 5894 3p25.2 human Y341-p 447750 GQRDSSYyWEIEASE enzymatic activity, inhibited; intracellular localization; protein conformation; phosphorylation; enzymatic activity, induced carcinogenesis, induced; cell growth, induced; cell motility, induced 10998357; 11259591; 11274179; 11447113; 12446733; 12551923; 12865432; 17998336; 18775988; 19595761; 27014871; 28694330; 7692235 35 1 1 dimerization, ERK activation +Apobec3 APOBEC3B iso3 EC 3.5.4.-; Hydrolase; RNA-binding Q99J72-3 80287 15 48.6 cM|15 E1 mouse T42-p 31825500 YAKGRKDtFLCYEVT APOBEC2 enzymatic activity, induced 24453360 1 0 0 +RIN1 Rin1 GEF; GEF, Rab Q13671 9610 11q13.2 human S351-p 451364 RPLLRSMsAAFCSLL molecular association, regulation; intracellular localization 14-3-3 beta(INDUCES) 11784866 3 23 4 +HIF1A HIF1A Autophagy; DNA-binding; Transcription factor Q16665 3091 14q23.2 human S589-p 34494909 PLESSSAsPESASPQ protein degradation cell growth, inhibited; cell motility, inhibited; signaling pathway regulation 30254159 1 0 0 PI3K pathway and AKT are strongly activated by IRIS +Cxcr4 CXCR4 GPCR, family 1; Membrane protein, integral; Membrane protein, multi-pass; Receptor, GPCR P70658 12767 1 E3|1 56.43 cM mouse S354-p 12575201 VSTESESsSFHSS__ receptor internalization, induced; receptor desensitization, inhibited; phosphorylation 23734232 1 2 1 +Sirt2 SIRT2 DEACETYLASE; Deacetylase; EC 3.5.1.- Q8VDQ8 64383 7|7 B1 mouse S368-p 482809 PNPSTTIsPGKSPPP intracellular localization transcription, altered 35443760 7 31 0 +Prkaca PKACA EC 2.7.11.11; KINASE; Kinase, protein; Protein kinase, AGC; Protein kinase, Ser/Thr (non-receptor) P05132 18747 8|8 C2 mouse S339-p 449886 EEEEIRVsINEKCGK molecular association, regulation PDK1(INDUCES) 19530248 13 36 28 +Gch1 GCH1 Cofactor and Vitamin Metabolism - folate biosynthesis; EC 3.5.4.16; Hydrolase P22288 29244 15p14 rat T91-p 10428813 KTPWRAAtAMQFFTK GTP_cyclohydroI enzymatic activity, induced 19762783 1 0 0 +Per1 PER1 Transcription factor O35973 18626 11|11 B3 mouse S663-p 451684 SYTASSAsDDDKQRA intracellular localization 15148313 1 0 0 +MDM2 MDM2 EC 6.3.2.-; EC 6.3.2.19; Inhibitor; Ligase; NEDDYLATION LIGASE; Neddylation Ligase; Nucleolus; Oncoprotein; UBIQUITIN LIGASE; Ubiquitin conjugating system; Ubiquitin ligase Q00987 4193 12q15 human S256-p 459215 FEVESLDsEDYSLSE activity, induced 12167711 3 1 0 promotes p53 degradation +Ncl NCL DNA-binding; Helicase; Nuclear receptor co-regulator; Nucleolus; RNA-binding P09405 17975 1 C5|1 43.94 cM mouse S41-p 468244 SEDEDDSsGEEEVVI molecular association, regulation carcinogenesis, induced; cell growth, induced; transcription, induced RNA(INDUCES) 37039106 1 41 7 +MYC Myc DNA-binding; Nucleolus; Oncoprotein; Transcription factor P01106 4609 8q24.21 human T358-p 25300958 ISNNRKCtSPRSSDT Myc_N carcinogenesis, inhibited; transcription, inhibited 24030976 2 2 1 +CERS4 LASS4 DNA-binding; Membrane protein, integral; Membrane protein, multi-pass Q9HA82 79603 19p13.2 human S347-p 36704607 IRSDVEEsDSSEEAA enzymatic activity, induced 26887952 1 2 0 +CS CS Carbohydrate Metabolism - citrate (TCA) cycle; Carbohydrate Metabolism - glyoxylate and dicarboxylate; EC 2.3.3.1; Mitochondrial; Transferase O75390 1431 12q13.3 human K395-m3 2358300 LLEQGKAkNPWPNVD Citrate_synt enzymatic activity, inhibited 28887308 2 2 3 +S100A11 S100A11 Calcium-binding; Cell cycle regulation; DNA replication P31949 6282 1q21.3 human S94-p 10888706 LAMACHDsFLKAVPS intracellular localization cell growth, altered NCL(INDUCES) 14623863 1 1 1 Nuclear translocation is mediated by T10 phosphorylation. Calcium induced growth inhibition is mediated by T10 and S94 phosphorylation. +MITF MITF iso9 DNA-binding; Oncoprotein; Transcription factor O75030-9 4286 3p13 human S405-p 31858102 PGASKTSsRRSSMSM DUF3371 protein degradation 25605940 1 1 0 +PRKD1 PRKD1 Autophagy; EC 2.7.11.13; KINASE; Kinase, protein; Motility/polarity/chemotaxis; Protein kinase, CAMK; Protein kinase, Ser/Thr (non-receptor) Q15139 5587 14q12 human S205-p 449896 GVRRRRLsNVSLTGV molecular association, regulation 14-3-3 beta(INDUCES) 15755722 8 36 86 +STAT3 STAT3 DNA-binding; Motility/polarity/chemotaxis; Nuclear receptor co-regulator; Transcription factor P40763 6774 17q21.2 human S727-p 448191 NTIDLPMsPRTLDSL activity, induced; molecular association, regulation; intracellular localization; activity, inhibited; phosphorylation cell cycle regulation; apoptosis, altered; carcinogenesis, induced; signaling pathway regulation; cell differentiation, altered; cell growth, induced; cell motility, altered; transcription, inhibited; cell growth, altered; carcinogenesis, inhibited; carcinogenesis, altered; transcription, induced; transcription, altered; DNA repair, induced; autophagy, induced; apoptosis, inhibited; autophagy, inhibited gp130(DISRUPTS); p300(INDUCES) DNA(INDUCES) 10521505; 10660304; 10727406; 10845908; 11322950; 11335711; 11350938; 11429693; 11536047; 11872739; 12087100; 12208955; 12562765; 12637318; 12684046; 14551213; 15155836; 15465816; 16951338; 17145757; 17209045; 17993646; 18550668; 18829527; 19265112; 20228845; 20516069; 20595392; 20871632; 21159613; 21398617; 21878628; 23740979; 24615012; 26028030; 28351946; 32015548; 33662027; 33689932; 33772065; 34207842; 34380633; 34852826; 34885140; 35031324; 35538489; 35595309; 35670018; 35928250; 36017196; 36103247; 36437465; 36443287; 7543024 227 57 67 +CDH1 CDH1 Cell adhesion; Membrane protein, integral; Motility/polarity/chemotaxis; UBIQUITIN LIGASE; Ubiquitin ligase P12830 999 16q22.1 human Y753-p 456024 DDTRDNVyYYDEEGG endocytosis, induced 29311227 2 2 42 +Kcnma1 KCNMA1 iso4 Channel, potassium; Endoplasmic reticulum; Membrane protein, integral; Membrane protein, multi-pass Q08460-4 16531 14|14 A3 mouse S701-p 23013300 GCRRPKMsIYKRMRR intracellular localization; activity, inhibited; palmitoylation 22084244 1 0 0 regulation of STREX cell surface expression, inhibits palmitoylation +RBM38 RBM38 RNA-binding Q9H0Z9 55544 20q13.31 human S195-p 29606707 DQYPYAAsPATAASF molecular association, regulation cell cycle regulation; carcinogenesis, induced; cell growth, inhibited; signaling pathway regulation; translation, induced; RNA stability, altered RBM38(DISRUPTS); eIF4G(INDUCES); AGO2(DISRUPTS); EIF4E(DISRUPTS) 24142875; 25823026; 30567739; 33472892; 33664057; 35568694 7 0 0 +TAB1 TAB1 Activator; Motility/polarity/chemotaxis Q15750 10454 22q13.1 human S395-gl 25160100 YPVSVPYsSAQSTSK activity, induced; phosphorylation signaling pathway regulation 22307082 1 3 0 may regulate TAB1 phosphorylation at S438; autophosphorylation of TAK1 T187 is reduced in 0-GlcNAc S395A mutatnt of TAB1 +Pax3 PAX3 DNA-binding; Oncoprotein; Transcription factor P24610 18505 1 C4|1 39.79 cM mouse S205-p 4145506 APQSDEGsDIDSEPD cell growth, induced; transcription, inhibited 27588498 6 1 0 +KDR VEGFR2 EC 2.7.10.1; KINASE; Kinase, protein; Membrane protein, integral; Protein kinase, TK; Protein kinase, tyrosine (receptor) P35968 3791 4q12 human Y822-p 56654294 EHCERLPyDASKWEF molecular association, regulation cytoskeletal reorganization Src(INDUCES) 35942094 1 1 0 mediates filopodia in endothelial cells +LY9 CD229 Cell surface; Membrane protein, integral Q9HBG7 4063 1q23.3 human Y651-p 455757 EIPESPTyENFT___ molecular association, regulation; receptor internalization, altered GRB2(INDUCES) 15879090 1 0 1 Grb2 binding induces CD229 internalization (dominant negative Grb2 (only SH2 domain) inhibits this as does Y651F mutation). +IRAK4 IRAK4 EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, Ser/Thr (non-receptor); Protein kinase, TKL Q9NWZ3 51135 12q12 human S346-p 2045338 FAQTVMTsRIVGTTA PK_Tyr_Ser-Thr protein conformation; enzymatic activity, induced 17141195; 17161373; 17312103 6 3 1 +Plk4 PLK4 EC 2.7.11.21; KINASE; Kinase, protein; Nucleolus; Protein kinase, Other; Protein kinase, Ser/Thr (non-receptor) Q64702 20873 3|3 B mouse T295-p 12654001 ATLSTTItASSGTSL protein degradation; ubiquitination 20100909 2 1 0 +Prkcd PKCD EC 2.7.11.13; KINASE; Kinase, protein; Nuclear receptor co-regulator; Protein kinase, AGC; Protein kinase, Ser/Thr (non-receptor); Protein kinase, tyrosine (non-receptor); Tumor suppressor P28867 18753 14 B|14 18.82 cM mouse S643-p 448591 LNEKPQLsFSDKNLI Pkinase_C intracellular localization; enzymatic activity, induced 15731106; 9305920 29 51 79 PKC-delta phosphorylation mediates monocytic differentiation of 32D myeloid progenitor cells. +PRKCE PKCE EC 2.7.11.13; KINASE; Kinase, protein; Protein kinase, AGC; Protein kinase, Ser/Thr (non-receptor) Q02156 5581 2p21 human T710-p 450184 TREEPVLtLVDEAIV Pkinase_C enzymatic activity, induced cell growth, induced 21806543 3 24 33 +BABAM1 NBA1 DNA repair, damage Q9NWV8 29086 19p13.11 human S29-p 479974 EPRPRTRsNPEGAED molecular association, regulation DNA repair, induced TNKS(INDUCES); RAP80(INDUCES) 26027929 1 26 247 promotes the association of BRCA1-A complex componentsin response to DNA damage +TRAP1 HSP75 Chaperone; Heat shock protein Q12931 10131 16p13.3 human S511-p 55374803 NRHLAEHsPYYEAMK HSP90 carcinogenesis, induced; cell growth, induced 28099845 1 1 0 +RET Ret EC 2.7.10.1; KINASE; Kinase, protein; Membrane protein, integral; Oncoprotein; Protein kinase, TK; Protein kinase, tyrosine (receptor) P07949 5979 10q11.21 human Y791-p 455479 HPHVIKLyGACSQDG PK_Tyr_Ser-Thr phosphorylation transcription, altered 15753368; 20080836 2 0 0 STAT3 Y705 phosphorylation +STK11IP STK11IP Protein kinase, regulatory subunit Q8N1F8 114790 2q35 human S404-p 4716927 EPRTLNPsPAGWFVQ molecular association, regulation; enzymatic activity, inhibited autophagy, inhibited ATP6V1A(INDUCES); ATP6V1B1(INDUCES) 35365663 1 13 3 inhibits V-ATPase activity +Stxbp4 STXBP4 Vesicle Q9WV89 20913 11|11 D mouse S99-p 455472 RAKLRSEsPWEIAFI molecular association, regulation STX4(DISRUPTS); GLUT4(DISRUPTS) 15753124; 17336927 3 1 2 Insulin induced Glut 4 translocation to the plasma membrane. +ARHGDIA RhoGDI alpha Apoptosis; Cell adhesion; Cell development/differentiation; G protein regulator, misc.; Motility/polarity/chemotaxis P52565 396 17q25.3 human S96-p 486318 DLTGDLEsFKKQSFV Rho_GDI activity, induced; molecular association, regulation signaling pathway regulation; transcription, altered RHOA(DISRUPTS); RAC1(DISRUPTS) 17636025; 23776598 3 0 0 promotes RhoA and Rac1 signaling, promotes amylase secretion from pancreatic acini; thrombin induced activation +ACLY ACLY Carbohydrate Metabolism - citrate (TCA) cycle; EC 2.3.3.8; Lyase; Transferase P53396 47 17q21.2 human S451-p 455372 STSTPAPsRTASFSE signaling pathway regulation 26039450 2 4 16 IGF1/AKT/ACL/cardiolipin/ATP pathway +FOXA2 FOXA2 DNA-binding; Transcription factor Q9Y261 3170 20p11.21 human K275-ac 3649009 GAAGSGKkAAAGAQA protein stabilization transcription, induced 24875183 2 2 1 +NME2 NME2 EC 2.7.13.3; EC 2.7.4.6; KINASE; Kinase, nucleoside diphosphate; Kinase, other; Nuclear receptor co-regulator; Nucleotide Metabolism - purine; Nucleotide Metabolism - pyrimidine; Protein kinase, histidine P22392 4831 17q21.33 human S44-p 23255088 AMKFLRAsEEHLKQH NDK molecular association, regulation CFTR(INDUCES) 26950439 1 7 1 induced by forskolin +TNFAIP1 TNFAIP1 DNA replication; Ubiquitin conjugating system Q13829 7126 17q11.2 human S280-p 3195881 SRSQASPsEDEETFE molecular association, regulation; intracellular localization PCNA(INDUCES) 19851886 2 11 0 nuclear localization +MAP2K4 MKK4 EC 2.7.12.2; KINASE; Kinase, protein; Protein kinase, STE; Protein kinase, dual-specificity (non-receptor) P45985 6416 17p12 human S80-p 447655 IERLRTHsIESSGKL activity, inhibited apoptosis, inhibited 11707464 8 16 87 +Slc6a3 DAT Membrane protein, integral; Membrane protein, multi-pass; Transporter; Transporter, SLC family P23977 24898 1p11 rat S7-p 451136 _MSKSKCsVGPMSSV molecular association, regulation; intracellular localization; protein conformation Other(INDUCES) 23161550; 26424792 6 1 1 Ser7 phosphorylation and increased transport correlates with Cys580 palmitoylation, differentially modulate DA transport Vmax, presence of phosphorylation and palmitoylation on cell surface transporters; increases DAT affinity for cocaine analog binding +XRCC5 Ku80 DNA-binding; EC 3.6.1.-; EC 3.6.4.-; Helicase; Nuclear receptor co-regulator; Nucleolus; RNA-binding P13010 7520 2q35 human K545-ub 12344141 PLIEAKKkDQVTAQE Ku_C molecular association, regulation DNA repair, induced DNA(DISRUPTS) 27895153 1 1 1 +CLCN1 CLCN1 Channel, chloride; Membrane protein, integral; Membrane protein, multi-pass; Transporter; Transporter, ion channel P35523 1180 7q34 human T891-p 14645303 LASFRNTtSTRKSTG activity, induced 20511714 1 0 0 +Vcp VCP Chaperone; DNA repair, damage; EC 3.6.4.6; Endoplasmic reticulum; Hydrolase Q01853 269523 4 A5|4 22.95 cM mouse Y805-p 449060 EDNDDDLyG______ molecular association, regulation; ubiquitination autophagy, inhibited UBXN6(DISRUPTS); PLAA(DISRUPTS); NGLY1(DISRUPTS); TSAd(INDUCES) 15752563; 17496150; 36300783 6 10 251 +Stat6 STAT6 DNA-binding; Transcription factor P52633 20852 10 D3|10 74.59 cM mouse R27-me 4258300 VDFPQRLrHLLADWL STAT_int molecular association, regulation; intracellular localization; phosphorylation DNA(INDUCES) 15153491 1 0 0 +TFCP2 TFCP2 DNA-binding; Transcription factor Q12800 7024 12q13.12-q13.13 human S291-p 7965107 TYVNNSPsPGFNSSH activity, inhibited; phosphorylation transcription, inhibited 19237534; 20682773 2 1 0 +LRP1 LRP1 Cell surface; Membrane protein, integral; Motility/polarity/chemotaxis; Receptor, misc. Q07954 4035 12q13.3 human S4517-p 4769100 LYMGGHGsRHSLAST molecular association, regulation; receptor internalization, altered GULP1(INDUCES); DAB1(INDUCES); SHC1(INDUCES) 15272003 1 0 0 +SPG11 SPG11 Membrane protein, integral; Membrane protein, multi-pass Q96JI7 80208 15q21.1 human S1955-p 482126 IPLRRVHsTSSLDSQ receptor internalization, induced; molecular association, regulation 14-3-3 beta(INDUCES); 14-3-3 theta(INDUCES); 14-3-3 zeta(INDUCES); 14-3-3 epsilon(INDUCES); 14-3-3 gamma(INDUCES); 14-3-3 eta(INDUCES) 36096339 1 20 100 +PCBP1 hnRNP E1 RNA splicing; RNA-binding; Translation Q15365 5093 2p13.3 human T127-p 478359 IKEIREStGAQVQVA KH_1 molecular association, regulation; intracellular localization RNA splicing, induced; transcription, induced; translation, induced; signaling pathway regulation DNA(INDUCES); RNA(DISRUPTS) 17389360 1 0 0 PKA-hnRNPE1 pathway +ZNF655 ZNF655 C2H2-type zinc finger protein Q8N720 79027 7q22.1 human K59-ub 52490407 ENKLLIPkQKISEEV protein degradation 26676607 0 1 0 +Rarg RARG iso2 DNA-binding; Nuclear receptor P18911-2 19411 15 F3|15 57.4 cM mouse S379-p 1869601000 ITDLRGIsTKGAERA Hormone_recep activity, induced cell adhesion, altered; signaling pathway regulation 31740618 1 0 0 +NME2 NME2 EC 2.7.13.3; EC 2.7.4.6; KINASE; Kinase, nucleoside diphosphate; Kinase, other; Nuclear receptor co-regulator; Nucleotide Metabolism - purine; Nucleotide Metabolism - pyrimidine; Protein kinase, histidine P22392 4831 17q21.33 human H118-p 474519 QVGRNIIhGSDSVKS NDK molecular association, regulation; enzymatic activity, induced KCNN4(INDUCES) 17157250; 8132589 3 0 0 H1118F mutant retained it's DNA binding and transcriptional activity in vitro. ; in vivo and in vitro +OXTR OXTR GPCR, family 1; Membrane protein, integral; Membrane protein, multi-pass; Receptor, GPCR P30559 5021 3p25.3 human S261-p 1876282802 RVALARVsSVKLISK 7tm_1 molecular association, regulation; phosphorylation signaling pathway regulation G-alpha(q)(INDUCES) 35104164 1 0 0 induces PKD1 and ERK1 phosphorylation, induces MAPK signaling +Csf1r CSFR EC 2.7.10.1; KINASE; Kinase, protein; Membrane protein, integral; Oncoprotein; Protein kinase, TK; Protein kinase, tyrosine (receptor) P09581 12978 18 E1|18 34.41 cM mouse Y697-p 451527 DSEGDSSyKNIHLEK PK_Tyr_Ser-Thr activity, induced; molecular association, regulation; enzymatic activity, induced cell cycle regulation; cell differentiation, altered; cell motility, altered; cytoskeletal reorganization; cell growth, altered GRB2(INDUCES); SOCS1(INDUCES) 11297560; 11997510; 17420255; 17420256; 18519746; 7545432; 8262059; 9380408 14 6 32 +PDCD6IP Alix Adaptor/scaffold; Apoptosis Q8WUM4 10015 3p22.3 human S718-p 8080236 QSIAREPsAPSIPTP molecular association, regulation cell cycle regulation Alix(DISRUPTS) 26859355 1 3 3 EIAV budding, cytokinetic abscission +KIT Kit EC 2.7.10.1; KINASE; Kinase, protein; Membrane protein, integral; Oncoprotein; Protein kinase, TK; Protein kinase, tyrosine (receptor) P10721 3815 4q12 human Y936-p 448019 SESTNHIySNLANCS protein degradation; molecular association, regulation; receptor internalization, altered GRB2(INDUCES); APS(INDUCES); GRB7(INDUCES); CBL(INDUCES) 12444928; 16780420 4 11 100 +SLK SLK EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, STE; Protein kinase, Ser/Thr (non-receptor) Q9H2G2 9748 10q24.33-q25.1 human S348-p 466944 SDLSIASsEEDKLSQ enzymatic activity, inhibited 16837460 1 30 3 site is critical for v-src dependent modulation of SLK kinase activity +MRE11 MRE11A Cell cycle regulation; DNA repair, damage; DNA-binding; Deoxyribonuclease P49959 4361 11q21 human R577-m2 62978404 RGRGRGRrGGRGQNS DNA repair, altered 15741314 0 1 0 +CSNK2A1 CK2A1 EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, Other; Protein kinase, Ser/Thr (non-receptor) P68400 1457 20p13 human T360-p 449985 SGISSVPtPSPLGPL molecular association, regulation; enzymatic activity, induced CK2A1(INDUCES); PGK1(INDUCES) 19941816; 30392930; 36646788 5 0 0 +BIK BIK Apoptosis; Membrane protein, integral; Mitochondrial Q13323 638 22q13.2 human T33-p 448350 TMEVLGMtDSEEDLD bcl-2I13 molecular association, regulation apoptosis, induced Bcl-2(INDUCES); Bcl-xL(INDUCES) 11084041; 14633680 3 0 0 +NUPR1 NUPR1 Apoptosis; Cell cycle regulation; Cell development/differentiation O60356 26471 16p11.2 human K69-ac 465462 HERKLVTkLQNSERK Phospho_p8 intracellular localization 16294328 1 1 0 regulates nuclear transport +CD6 CD6 Cell surface; Membrane protein, integral P30203 923 11q12.2 human S565-p 28095005 PRSNSESsTSSGEDY phosphorylation signaling pathway regulation 23711376 1 0 0 ERK1/2 phosphorylation, MAPK pathway activation +DIABLO DIABLO Apoptosis; Mitochondrial Q9NR28 56616 12q24.31 human S6-p 31857552 __MAALKsWLSRSVT intracellular localization apoptosis, induced 25310587 1 1 0 mitochondrial release of DIABLO during TNF induced apoptosis +Cacng2 Stargazin Channel, calcium; Membrane protein, integral; Membrane protein, multi-pass Q71RJ2 84347 7q34 rat S240-p 455316 YQRRSRSsSRSTEPS molecular association, regulation neural plasticity PSD-95(INDUCES) 25843401 7 0 0 +Tsc2 TSC2 iso2 Cell cycle regulation; GAP; GAP, misc.; Nuclear receptor co-regulator; Tumor suppressor P49816-2 24855 10q12 rat S1342-p 450216 FQPSQPLsKSSSSPE phosphorylation apoptosis, altered; cell growth, altered 14651849 2 1 1 +Cnr1 CNR1 GPCR, family 1; Membrane protein, integral; Membrane protein, multi-pass; Receptor, GPCR P47746 12801 4 A5|4 16.28 cM mouse T468-p 22342301 TMSVSTDtSAEAL__ receptor desensitization, induced 22014214 2 0 0 +ECD SGT1 Transcription, coactivator/corepressor O95905 11319 10q22.2 human S505-p 3178824 PRPNESDsDDLDDED SGT1 molecular association, regulation cell cycle regulation PIH1D1(INDUCES) 24656813; 26711270 2 8 0 +Gli2 GLI2 C2H2-type zinc finger protein; Oncoprotein; Transcription factor Q0VGT2 14633 1 E2.3|1 52.17 cM mouse S817-p 1717520 YFSSRRSsEASPLGG sumoylation 22549777 1 0 2 +MAF MAF Cell development/differentiation; DNA-binding; Oncoprotein; Transcription factor; Tumor suppressor O75444 4094 16q23.2 human Y21-p 25673104 TSPLAMEyVNDFDLM activity, induced; molecular association, regulation transcription, induced DNA(INDUCES) 22798672 2 0 0 Interacts with IL-4 promoter and transactivates IL-4 +Fyn Fyn EC 2.7.10.2; KINASE; Kinase, protein; Oncoprotein; Protein kinase, TK; Protein kinase, tyrosine (non-receptor) Q62844 25150 20q12 rat Y531-p 447883 FTATEPQyQPGENL_ enzymatic activity, inhibited 19625508 19 15 1040 +CDKN1B p27Kip1 Cell cycle regulation; Inhibitor; Oncoprotein; Protein kinase, regulatory subunit P46527 1027 12p13.1 human S12-p 9316305 RVSNGSPsLERMDAR intracellular localization carcinogenesis, induced; apoptosis, inhibited 33316141 2 6 0 nuclear localization +PCNA PCNA Cell cycle regulation; DNA replication P12004 5111 20p12.3 human Y60-p 38486265 RSEGFDTyRCDRNLA PCNA_N ubiquitination cell cycle regulation 28924044 1 1 0 +STMN1 STMN1 Cytoskeletal P16949 3925 1p36.11 human S16-p 448554 KELEKRAsGQAFELI Stathmin molecular association, regulation; activity, inhibited; phosphorylation cell cycle regulation; carcinogenesis, induced; apoptosis, altered; carcinogenesis, inhibited; cell growth, inhibited; apoptosis, induced; cell motility, inhibited; signaling pathway regulation; cell growth, induced; cytoskeletal reorganization TUBA1A(DISRUPTS); TUBA4A(DISRUPTS); TACC3(INDUCES); TUBB(DISRUPTS) 10913145; 11015208; 14645234; 16554300; 19359244; 20110360; 21768358; 26317901; 27041561; 30786936; 31546234; 36221072; 7775478; 9271428 38 98 61 +WT1 WT1 C2H2-type zinc finger protein; DNA-binding; Nucleolus; Transcription factor; Tumor suppressor P19544 7490 11p13 human S393-p 451121 KTCQRKFsRSDHLKT zf-C2H2 transcription, altered 9366517 1 0 0 Phosphorylation of S365 and S393 inhibited WT1 DNA-binding, and thereby decreased WT1 transcriptional repression activity. +RFC1 RFC1 DNA replication P35251 5981 4p14 human T506-p 2915401 KESKLERtPQKNVQG molecular association, regulation PCNA(DISRUPTS) 12930972 1 12 10 +HMGCR HMGCR EC 1.1.1.34; Endoplasmic reticulum; Membrane protein, integral; Membrane protein, multi-pass; Motility/polarity/chemotaxis; Oxidoreductase; Secondary Metabolites Metabolism - terpenoid backbone biosynthesis Q1W675 100144446 pig S869-p 448568 SHMIHNRsKINLQDL signaling pathway regulation 23799098 5 11 0 simvastatin-induced signaling for the closure of K-ATP channel +SMURF2 SMURF2 EC 6.3.2.-; EC 6.3.2.19; Ligase; UBIQUITIN LIGASE; Ubiquitin conjugating system; Ubiquitin ligase Q9HAU4 64750 17q23.3-q24.1 human S384-p 1870790704 KILRQELsQQQPQAG molecular association, regulation; enzymatic activity, induced DNA repair, altered RNF20(INDUCES) 33097595 1 1 0 DNA repair delayed, +MITF MITF DNA-binding; Oncoprotein; Transcription factor O75030 4286 3p13 human S180-p 450264 PGSSAPNsPMAMLTL MITF_TFEB_C_3_N protein degradation; ubiquitination carcinogenesis, induced; cell motility, induced; cell growth, induced 10694430; 36268034 16 1 0 +PAWR PAR-4 Apoptosis Q96IZ0 5074 12q21.2 human T163-p 456964 LREKRRStGVVNIPA signaling pathway regulation 31834925 3 1 31 +SYMPK Symplekin Motility/polarity/chemotaxis; RNA processing Q92797 8189 19q13.32 human T1257-p 3208452 VGEDAMKtPSPAAED intracellular localization cell growth, induced; transcription, induced 28630428 1 24 7 nuclear accumulation, TJ localization +STAT3 STAT3 DNA-binding; Motility/polarity/chemotaxis; Nuclear receptor co-regulator; Transcription factor P40763 6774 17q21.2 human T622-p 1877503800 KEGGVTFtWVEKDIS SH2 molecular association, regulation; activity, inhibited carcinogenesis, inhibited; cell growth, inhibited; transcription, inhibited STAT3(INDUCES) 35722967 1 0 0 +FANCA FANCA DNA repair, damage O15360 2175 16q24.3 human T351-p 11076033 REWSFARtHPLLTSL Fanconi_A_N cell cycle regulation; cytoskeletal reorganization 23806870 1 0 1 maintenance of centrosomal integrity +CDC25A CDC25A EC 3.1.3.48; Motility/polarity/chemotaxis; PHOSPHATASE; Protein phosphatase, dual-specificity P30304 993 3p21.31 human T507-p 450483 KFRTKSRtWAGEKSK molecular association, regulation; enzymatic activity, inhibited; activity, inhibited apoptosis, altered 14-3-3 beta(INDUCES); CCNA1(DISRUPTS); CDK2(DISRUPTS); CDK1(DISRUPTS); CCNB1(DISRUPTS) 14559997; 20368335 4 2 0 +Cebpb C/EBP-beta DNA-binding; Motility/polarity/chemotaxis; Transcription factor P21272 24253 3q42 rat Y109-p 13373503 KKPSDYGyVSLGRAG molecular association, regulation cell growth, induced; transcription, induced DNA(INDUCES) 20351173 1 4 12 +Il21r IL21R Membrane protein, integral; Receptor, cytokine Q9JHX3 60504 7|7 F3 mouse Y510-p 475069 DEGPPRSyLRQWVVR phosphorylation cell growth, altered 17234735 1 0 0 +ALKBH5 ALKBH5 DEMETHYLASE; DNA repair, damage; Demethylase; EC 1.14.11.-; Membrane protein, integral; Oxidoreductase; RNA-binding Q6P6C2 54890 17p11.2|17p11.2 human K132-ac 11323057 DRAPLRNkYFFGEGY 2OG-FeII_Oxy_2 enzymatic activity, induced 32989163 0 3 1 +Grm5 mGluR5 GPCR, family 3; Membrane protein, integral; Membrane protein, multi-pass; Receptor, GPCR P31424 24418 1q32 rat S839-p 455778 VRSAFTTsTVVRMHV activity, induced 15894802 1 5 2 Phosphorylation increases calcium oscillations. Not T840 as believed in a previous paper (mutation of T840D decreases the phosphorylation of S839 though). +TJP2 ZO2 Adaptor/scaffold; Motility/polarity/chemotaxis Q95168 403854 dog S369-p 9730701 QLVVLRDsKQTLINI intracellular localization 19625451; 23804652 2 2 0 +Cacng2 Stargazin Channel, calcium; Membrane protein, integral; Membrane protein, multi-pass Q71RJ2 84347 7q34 rat S239-p 455315 RYQRRSRsSSRSTEP molecular association, regulation neural plasticity PSD-95(INDUCES) 25843401 7 0 0 +Card11 CARD11 Adaptor/scaffold Q8CIS0 108723 5|5 G2 mouse S649-p 457638 NLMLRKFsLERPFRP activity, inhibited apoptosis, altered; cell growth, altered 19917688 5 4 3 +RPAP3 RPAP3 Unknown function Q9H6T3 79657 12q13.11 human S121-p 1279825 SLSQESEsEEDGIHV molecular association, regulation 35129352 1 24 9 inhibits binding to ribosomal proteins and biogenesis factors associated with small (40S) and large (60S) subunits of the ribosome +Nfatc2 NFAT1 DNA-binding; Transcription factor Q60591 18019 2 H3|2 88.91 cM mouse S173-p 447840 PLCLSPAsSGSSASF transcription, inhibited 11030334 0 1 0 +Cdk5r1 CDK5R1 Protein kinase, regulatory subunit P61809 12569 11 B5|11 47.94 cM mouse S91-p 12607404 ENLKKSLsCANLSTF protein degradation 28566287 4 0 0 +SMN1 SMN RNA processing; RNA-binding Q16637 6606 5q13.2 human Y109-p 1016077 WSEDGCIyPATIASI SMN molecular association, regulation; intracellular localization coilin(INDUCES) 24602413 1 2 0 +NDE1 NUDE1 iso1 Cell cycle regulation; Cytoskeletal; Microtubule-binding Q9NXR1-1 54820 16p13.11 human T131-p 20609200 LERAKRAtIMSLEDF molecular association, regulation; protein conformation cytoskeletal reorganization NDEL1(INDUCES); PAFAH1B1(DISRUPTS) 21677187 1 0 0 phosphomimetic mutant inhibits neurite extension +PKD2 PKD2 Channel, cation; Membrane protein, integral; Membrane protein, multi-pass Q13563 5311 4q22.1 human S812-p 451598 FPRSLDDsEEDDDED activity, induced; molecular association, regulation PACS2(INDUCES); CBY1(DISRUPTS) 14742446; 23838289 3 24 8 +GHRL ghrelin Apoptosis; Cell cycle regulation; Cell development/differentiation; Secreted; Secreted, signal peptide Q9UBU3 51738 3p25.3 human S41-p 2235100 RVQQRKEsKKPPAKL Motilin_ghrelin intracellular localization; protein conformation 18343535 1 0 0 disrupts ghrelin structure and its binding to membranes +CRYAA CRYA1 Chaperone; Heat shock protein P02489 1409 21q22.3 human K99-ac 7482009 DFVEIHGkHNERQDD HSP20 activity, induced; molecular association, regulation; protein conformation 22120592 1 3 0 increased chaperone function with client proteins +UNG UNG EC 3.2.2.27; Hydrolase P13051 7374 12q24.11 human S64-p 2018601 EPGTPPSsPLSAEQL protein degradation; molecular association, regulation; ubiquitination; protein conformation; enzymatic activity, induced DNA repair, induced RPA1(DISRUPTS) 18079698; 27875297 3 19 14 +PML PML Nucleolus; Oncoprotein; SUMO LIGASE; SUMO conjugating system; SUMO ligase; Transcription factor; Tumor suppressor; Ubiquitin conjugating system P29590 5371 15q24.1 human S560-p 6835504 EERVVVIsSSEDSDA DUF3583 molecular association, regulation SUMO2(INDUCES); SUMO1(INDUCES); SUMO3(INDUCES) 19217413; 19380586 2 6 0 PML interaction with SUMO-modified protein partners and PML nuclear bodies maturation +NCOA3 SRC-3 ACETYLTRANSFERASE; Acetyltransferase; EC 2.3.1.48; Motility/polarity/chemotaxis; Nuclear receptor co-regulator; Transcription, coactivator/corepressor Q9Y6Q9 8202 20q13.12 human T24-p 454110 KRKLPCDtPGQGLTC molecular association, regulation carcinogenesis, induced; cell growth, induced; transcription, induced ER-alpha(DISRUPTS) 15383283; 23850489; 33542078 5 1 0 +Prdx6 PRDX6 Amino Acid Metabolism - phenylalanine; EC 1.11.1.15; EC 1.11.1.9; Energy Metabolism - methane; Oxidoreductase; Phospholipase O35244 94167 13q22 rat T177-p 3823356 TASNPVAtPVDWKKG 1-cysPrx_C enzymatic activity, induced 19140803 4 5 12 in vitro +BCL2L11 BIM Apoptosis O43521 10018 2q13 human K112-ub 25087002 PAPMSCDkSTQTPSP protein degradation apoptosis, inhibited 14657036 2 0 0 +Map3k2 MEKK2 EC 2.7.11.25; KINASE; Kinase, protein; Protein kinase, STE; Protein kinase, Ser/Thr (non-receptor) Q61083 26405 18|18 B1 mouse S153-p 3216819 AERKKRLsVVGPPNR signaling pathway regulation 16581779 3 51 11 cAMP-regulated growth factor receptor signaling +Prkcb PKCB EC 2.7.11.13; KINASE; Kinase, protein; Motility/polarity/chemotaxis; Protein kinase, AGC; Protein kinase, Ser/Thr (non-receptor) P68404 18751 7 F2|7 65.75 cM mouse Y662-p 455926 NEFAGFSyTNPEFVI Pkinase_C molecular association, regulation GRB2(INDUCES) 12881490 1 0 0 +IKBKE IKKE EC 2.7.11.10; Inhibitor; KINASE; Kinase, protein; Protein kinase, Other; Protein kinase, Ser/Thr (non-receptor) Q14164 9641 1q32.1 human S172-p 447631 DDDEKFVsVYGTEEY Pkinase enzymatic activity, induced 11839743; 23478265; 27346349 8 4 0 T cell activation +BRCA1 BRCA1 EC 6.3.2.-; Nuclear receptor co-regulator; Transcription, coactivator/corepressor; Tumor suppressor; UBIQUITIN LIGASE; Ubiquitin conjugating system; Ubiquitin ligase P38398 672 17q21.31 human S114-p 18007298 FAKKENNsPEHLKDE molecular association, regulation; intracellular localization DNA repair, induced PIN1(INDUCES); RAD51(INDUCES) 31270457 1 15 1 +Vim Vimentin Cytoskeletal; Motility/polarity/chemotaxis P20152 22352 2 A1|2 10.04 cM mouse S5-p 471086 ___MSTRsVSSSSYR molecular association, regulation endocytosis, induced JAG1(INDUCES) 28533359 3 10 3 transendocytosis +AFF1 AF-4 Oncoprotein; Transcription factor P51825 4299 4q21.3-q22.1 human S212-p 3191671 PSPVPPLsPIHSNQQ AF-4 protein degradation; molecular association, regulation; intracellular localization transcription, induced 14-3-3 theta(INDUCES); CDK9(INDUCES) 21574958 1 28 6 nuclear import-export +GAS2L1 GAS2L1 Cytoskeletal Q99501 10634 22q12.2 human S352-p 1974202 HPRSRRYsGDSDSSA molecular association, regulation; protein conformation cell cycle regulation; chromatin organization, altered MICAL1(INDUCES) 32289147 1 13 2 centrosome seperation increase F-actin binding activity +NFATC3 NFAT4 DNA-binding; Transcription factor Q12968 4775 16q22.1 human T204-p 11507601 NEAAARFtLGSPLTS intracellular localization 9630228 1 0 0 cytoplasmic localization (inhibition of nuclear localization) +Lpp LPP Adaptor/scaffold; Cytoskeletal; Motility/polarity/chemotaxis Q8BFW7 210126 16|16 B1 mouse Y298-p 449713 TSNQGRYyEPYYAAG cell cycle regulation; cell motility, altered 18515860 1 7 43 +RC3H2 MNAB DNA-binding; UBIQUITIN LIGASE; Ubiquitin conjugating system; Ubiquitin ligase Q9HBD1 54542 9q33.2 human Y691-p 1253812003 PPVPSGMyAPVYDSR protein stabilization; molecular association, regulation; ubiquitination KLHL6(DISRUPTS) 30209976 1 0 0 phosphorylation inhibits ubiquitin mediated degradation +Arrb1 ARRB1 Adaptor/scaffold P29066 25387 1q32 rat Y54-p 458023 YLKERRVyVTLTCAF Arrestin_N molecular association, regulation; receptor internalization, altered AP3M1(DISRUPTS) 17456469 1 1 1 decreases beta 2 adrenergic receptor internalization +Rptor Raptor Adaptor/scaffold Q8K4Q0 74370 11|11 E2 mouse S863-p 453732 LTQSAPAsPTNKGMH molecular association, regulation signaling pathway regulation PRAS40(INDUCES); p70S6K(INDUCES) 24239769 13 101 6 mechanical stress-induced mTOR signaling +CDC20 CDC20 Cell cycle regulation; Ubiquitin conjugating system Q12834 991 1p34.2 human T70-p 455844 SSSKVQTtPSKPGGD activity, inhibited cell cycle regulation 29084198; 33819340 2 23 7 +EPOR EPOR Membrane protein, integral; Receptor, cytokine P19235 2057 19p13.2 human Y468-p 451266 DSGISTDySSGDSQG apoptosis, inhibited 14662339 3 0 0 +GABRA4 GABRA4 Channel, chloride; Channel, ligand-gated; Membrane protein, integral; Membrane protein, multi-pass; Transporter; Transporter, ion channel P48169 2557 4p12 human S474-p 17390700 KASVGSAsTRHVFGS Neur_chan_memb protein stabilization; intracellular localization endocytosis, induced 20940303; 24778259 2 1 0 membrane insertion of receptor complex; increases receptor cell surface expression +Crtc2 TORC2 Transcription, coactivator/corepressor Q3LRZ1 310615 2q34 rat S171-p 454622 SALNRTSsDSALHTS TORC_M activity, induced 32020874 19 10 12 +Gphn gephyrin Adaptor/scaffold; EC 2.10.1.1; EC 2.7.7.75 Q03555 64845 6q24 rat S290-p 3213525 SPRAQATsRLSTASC molecular association, regulation gephyrin(INDUCES) 22778260 2 2 1 oligomerization +OTUB1 OTUB1 DEUBIQUITINASE; EC 3.4.19.12; Protease; Ubiquitin conjugating system; Ubiquitin-specific protease Q96FW1 55611 11q13.1 human K122-m1 1883522702 KAVSAKSkEDLVSQG molecular association, regulation UBE2N(DISRUPTS) 36822329 1 1 0 methylation of OTUB1 relieves the suppressive role of OTUB1 on ferroptosis +RAPH1 RAPH1 Adaptor/scaffold; Motility/polarity/chemotaxis Q70E73 65059 2q33.2 human S1071-p 1883958002 FPSPPSDsDFPPPPP intracellular localization cell motility, induced VASP(DISRUPTS) 37632751 1 1 0 regulates MENA localization +Ghr GH receptor Membrane protein, integral; Receptor, cytokine P16310 25235 2q16 rat Y338-p 455508 DNYKPDFyNDDSWVE GHBP molecular association, regulation SOCS3(INDUCES) 10585430 2 0 0 +DYRK2 DYRK2 iso2 EC 2.7.12.1; KINASE; Kinase, protein; Protein kinase, CMGC; Protein kinase, dual-specificity (non-receptor) Q92630-2 8445 12q15 human T82-p 1874397808 KVKATPMtPEQAMKQ intracellular localization cell cycle regulation; apoptosis, induced 34363019 1 1 0 +PML PML Nucleolus; Oncoprotein; SUMO LIGASE; SUMO conjugating system; SUMO ligase; Transcription factor; Tumor suppressor; Ubiquitin conjugating system P29590 5371 15q24.1 human S403-p 3189643 AAVSKKAsPEAASTP DUF3583 carcinogenesis, altered 20832753 1 44 44 +LGALS3 galectin-3 Cell surface; Extracellular matrix; Motility/polarity/chemotaxis P17931 3958 14q22.3 human Y107-p 14823408 AYPATGPyGAPAGPL activity, induced; protein processing; protein conformation cell motility, induced; cell motility, altered 20600357; 22232548; 24269589 3 0 0 regulates cell morphology; prevents galectin-3 cleavage; Phosphorylation of S6 and S12 In N-terminal promotes association with carbohydrate recognition domain (CRD), while phosphorylation of Y107 and Y118 attenuates this interaction. +IRF6 IRF6 DNA-binding; Transcription factor O14896 3664 1q32.2 human S413-p 18911095 FSGDFTRsFDSGSVR activity, induced; protein conformation transcription, induced 24872416; 25246526 3 3 0 +Phldb2 PHLDB2 Vesicle Q8K1N2 208177 16|16 B5 mouse S465-p 483335 KPEGRRLsAGTTVAD protein degradation 31775047 1 37 26 +NPM/ALK NPM-ALK KINASE; Kinase, protein; Protein kinase, TK; Protein kinase, tyrosine (receptor) AAA58698 human S135-p 27275118 AMQMELQsPEYKLSK phosphorylation carcinogenesis, altered; cell growth, altered 21045017 1 1 0 +ANXA1 ANXA1 Calcium-binding; Lipid-binding P04083 301 9q21.13 human K312-ac 461553 EIDMNDIkAFYQKMY Annexin protein degradation; molecular association, regulation; intracellular localization; phosphorylation autophagy, induced PKAR2B(INDUCES) 34601098 1 8 31 autophagy induced to degrade PRKAR2B; reduced caspase-3 and caspase-9 activity by increasing phosphorylation level of caspase-9 +HSF1 HSF1 DNA-binding; Transcription factor Q00613 3297 8q24.3 human S419-p 455264 SALLDLFsPSVTVPD Vert_HS_TF carcinogenesis, induced; cell growth, induced 35906200 5 1 0 +SPAG9 JIP4 Adaptor/scaffold; Cancer Testis Antigen (CTA) O60271 9043 17q21.33 human T217-p 449392 PAGDGLLtPDAQKGG molecular association, regulation autophagy, induced mucolipin 1(INDUCES); ALG2(INDUCES) 36394115 1 58 42 +BANF1 BAF DNA-binding O75531 8815 11q13.1 human S4-p 458302 ____MTTsQKHRDFV BAF molecular association, regulation; intracellular localization; protein conformation cell cycle regulation lamin A/C(DISRUPTS); BAF(DISRUPTS) DNA(INDUCES); DNA(DISRUPTS) 16371512; 16495336; 24265311; 24600006; 24945635; 25899223; 33744941; 36402223 9 19 0 +Grin2a NMDAR2A Channel, ligand-gated; Membrane protein, integral; Membrane protein, multi-pass P35436 14811 16 A1|16 5.28 cM mouse Y1325-p 458211 RLLEGNLyGSLFSVP NMDAR2_C activity, induced; phosphorylation neural plasticity; cell adhesion, induced 19834457; 33975959; 35536885 8 2 84 +PDPK1 PDK1 EC 2.7.11.1; KINASE; Kinase, protein; Nuclear receptor co-regulator; Protein kinase, AGC; Protein kinase, Ser/Thr (non-receptor) O15530 5170 16p13.3 human S396-p 448582 SSSSSSHsLSASDTG intracellular localization transcription, altered 15743829 4 1 0 regulates nuclear accumulation and inhibits transcription through FOXO3a +NCL NCL DNA-binding; Helicase; Nuclear receptor co-regulator; Nucleolus; RNA-binding P19338 4691 2q37.1 human T641-p 21697920 EIDGNKVtLDWAKPK RRM_1 molecular association, regulation; protein stabilization carcinogenesis, induced; cell growth, induced; RNA stability, induced; translation, induced RNA(INDUCES) 21998300; 25173817 2 0 1 induces binding to Sp1 RNA and IRES-mediated Sp1 expression +NPM1 NPM1 Nucleolus; Oncoprotein; RNA-binding; Translation P06748 4869 5q35.1 human T199-p 448515 VKKSIRDtPAKNAQK protein degradation; acetylation; molecular association, regulation; ubiquitination; intracellular localization; activity, inhibited cell cycle regulation; carcinogenesis, induced; transcription, inhibited MDM2(DISRUPTS) RNA(DISRUPTS) 12058066; 18165222; 20333249; 20713529; 24998852; 26993766; 30453269; 32076484; 32092641 24 29 30 +UNG UNG EC 3.2.2.27; Hydrolase P13051 7374 12q24.11 human T60-p 452622 AGQEEPGtPPSSPLS protein degradation; molecular association, regulation; ubiquitination; phosphorylation; enzymatic activity, induced DNA repair, induced RPA1(DISRUPTS) 18079698; 27875297 2 37 35 +ADD2 ADD2 Cytoskeletal; Motility/polarity/chemotaxis P35612 119 2p13.3 human S693-p 454590 SVTSGPMsPEGSPSK phosphorylation 21606488 1 16 0 CDK5 primes sites for phosphorylation by GSK3B +WEE1 Wee1 EC 2.7.10.2; KINASE; Kinase, protein; Protein kinase, Other; Protein kinase, Ser/Thr (non-receptor); Protein kinase, tyrosine (non-receptor) P30291 7465 11p15.4 human S212-p 25316778 SVKLRGSsLFMDTEK protein degradation; molecular association, regulation BTRC(INDUCES) 24817118 1 1 1 +DAXX DAXX Apoptosis; Nuclear receptor co-regulator; Nucleolus; Transcription, coactivator/corepressor Q9UER7 1616 6p21.32 human K630-sm 2407410 GDSGPPCkKSRKEKK molecular association, regulation; intracellular localization cell growth, inhibited; transcription, inhibited PML(INDUCES) 16818774 4 0 0 +PRKCE PKCE EC 2.7.11.13; KINASE; Kinase, protein; Protein kinase, AGC; Protein kinase, Ser/Thr (non-receptor) Q02156 5581 2p21 human T349-p 486054 DRSKSAPtSPCDQEI molecular association, regulation 14-3-3 zeta(DISRUPTS) 34143863 1 4 0 +KAT7 MYST2 ACETYLTRANSFERASE; Acetyltransferase; EC 2.3.1.48; Nuclear receptor co-regulator; Transcription, coactivator/corepressor O95251 11143 17q21.33 human S53-p 460901 SARLSQSsQDSSPVR protein degradation; molecular association, regulation; ubiquitination cell cycle regulation; cell growth, inhibited DDB2(INDUCES) 26572825 1 20 29 +DDB1 DDB1 DNA repair, damage Q16531 1642 11q12.2 human Y316-p 62873404 SIAECLTyLDNGVVF MMS1_N molecular association, regulation DDA1(INDUCES) 28087699 1 0 0 ubiquitination of CRL4 substrates +RBL2 Rb-like 2 Transcription, coactivator/corepressor; Tumor suppressor Q08999 5934 16q12.2 human S413-p 449724 VRYIKENsPCVTPVS molecular association, regulation cell cycle regulation E2F4(DISRUPTS) 11157749; 12006580 3 19 2 +PHLPP1 PHLPP EC 3.1.3.16; PHOSPHATASE; Protein phosphatase, Ser/Thr (non-receptor); Tumor suppressor O60346 23239 18q21.33 human S450-p 36134756 VAPGGLQsTPGRSGV cell cycle regulation 33397691 1 2 0 +CETN1 CETN1 Q12798 1068 18p11.32 human T138-p 34405000 NELGENLtDEELQEM EF-hand_7 molecular association, regulation G-beta 1(DISRUPTS); SFI1(DISRUPTS) 24918055 1 0 0 +TIAM1 TIAM1 GEF; GEF, Rac/Rho; Motility/polarity/chemotaxis; Oncoprotein Q13009 7074 21q22.11 human T340-p 35524907 DSGIEGAtTDTDLLS molecular association, regulation BTRC(INDUCES) 25124033 1 1 0 +GABBR1 GABBR1 GPCR, family 3; Membrane protein, integral; Membrane protein, multi-pass; Receptor, GPCR Q9UBS5 2550 6p22.1 human Y404-p 1875398100 ADNWFKIyDPSINCT ANF_receptor molecular association, regulation; phosphorylation carcinogenesis, induced; cell growth, induced; signaling pathway regulation PTP-PEST(INDUCES) 34778730 1 0 0 binding to PTP-PEST inhibits PTP-PEST binding to EGFR, induces EGFR phosphorylation, thus regulating AKT signaling +Zdhhc3 ZDHHC3 EC 2.3.1.225; Membrane protein, integral; Membrane protein, multi-pass; Transferase Q8R173 69035 9|9 F4 mouse Y18-p 462842 DIERKPEyLQPEKCA enzymatic activity, induced cytoskeletal reorganization 27247265 1 0 20 neurite outgrowth; palmitoylation +PSEN1 PSEN1 Cell surface; EC 3.4.23.-; Membrane protein, integral; Membrane protein, multi-pass; Mitochondrial; Protease P49768 5663 14q24.2 human S346-p 450179 EWEAQRDsHLGPHRS Presenilin apoptosis, inhibited 14576165 1 0 1 Phosphorylation at S346 regulates the caspase-mediated cleavage of PS1 and inhibits progression of apoptosis. +RAB11A RAB11A G protein; G protein, monomeric; G protein, monomeric, Rab; Motility/polarity/chemotaxis P62491 8766 15q22.31 human K145-ub 15395883 EARAFAEkNGLSFIE Ras receptor recycling, induced; enzymatic activity, induced 24190883 1 1 5 +CSNK1E CK1E EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, CK1; Protein kinase, Ser/Thr (non-receptor) P49674 1454 22q13.1 human T325-p 453417 GQLRGSAtRALPPGP enzymatic activity, inhibited 10542239; 12223474 2 1 1 some subset of these 8 sites +Pitx2 PITX2 Cell cycle regulation; DNA-binding; Motility/polarity/chemotaxis; Transcription factor P97474 18741 3 G3|3 57.84 cM mouse T90-p 25790902 KRQRRQRtHFTSQQL Homeodomain molecular association, regulation cell growth, inhibited; cell differentiation, induced; RNA stability, inhibited 14-3-3 zeta(INDUCES); HuR(DISRUPTS) 20019746 1 0 0 +SLC43A2 SLC43A2 Membrane protein, integral; Membrane protein, multi-pass; Transporter; Transporter, SLC family Q8N370 124935 17p13.3 human S274-p 2508983 TTVGRRLsVGSSMRS MFS_1 protein stabilization; intracellular localization; activity, inhibited 30379325 2 28 1 membrane localization & transport activity decreased, leades to mature, core-glycosylated form, regulation of amino acid absorption +AIP AIP Nuclear receptor co-regulator; Transcription, coactivator/corepressor O00170 9049 11q13.2 human S132-p 10888702 AQMREHSsLGHADLD molecular association, regulation HSP90A(INDUCES) 12361709 2 0 0 +Myocd myocardin Cell development/differentiation; Transcription factor Q8VIM5 214384 11|11 B3 mouse S859-p 10791202 ELLPGPLsPMHAQLS molecular association, regulation transcription, inhibited CBP(DISRUPTS) 19776005 1 0 0 +AURKB AurB EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, Other; Protein kinase, Ser/Thr (non-receptor) Q96GD4 9212 17p13.1 human K202-ub 21129738 KVIHRDIkPENLLLG Pkinase molecular association, regulation; enzymatic activity, induced cell cycle regulation 36473924 2 4 0 formation of CPC complex, required for proper mitotic progression, critical site for cell survival +IRAK1 IRAK1 EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, Ser/Thr (non-receptor); Protein kinase, TKL P51617 3654 Xq28 human S163-p 60189902 PELGLVPsPASLWPP molecular association, regulation PIN1(INDUCES) 27790836 1 0 0 bivalent advantage for Pin1 binding +Mapk7 ERK5 EC 2.7.11.24; KINASE; Kinase, protein; Protein kinase, CMGC; Protein kinase, Ser/Thr (non-receptor) Q9WVS8 23939 11|11 B2 mouse S760-p 14561007 PQDGQADsASLSASL transcription, altered 17928297 2 1 0 +HIF1A HIF1A Autophagy; DNA-binding; Transcription factor Q16665 3091 14q23.2 human S247-p 15434302 KTFLSRHsLDMKFSY molecular association, regulation; activity, inhibited cell cycle regulation; carcinogenesis, altered; transcription, inhibited ARNT(DISRUPTS) 20699359 1 0 0 +CDH1 CDH1 Cell adhesion; Membrane protein, integral; Motility/polarity/chemotaxis; UBIQUITIN LIGASE; Ubiquitin ligase P12830 999 16q22.1 human S840-p 15754600 FDYEGSGsEAASLSS CADH_Y-type_LIR protein stabilization carcinogenesis, altered; cell motility, inhibited 35115926 5 1 0 +Nfatc2 NFAT1 DNA-binding; Transcription factor Q60591 18019 2 H3|2 88.91 cM mouse S56-p 455327 HKAISSPsGLAYPDD transcription, induced 11030334 0 2 0 +Axin1 axin 1 Adaptor/scaffold; Tumor suppressor O35625 12005 17 A3.3|17 13.07 cM mouse S485-p 451092 MRTPGCQsPGPGHRS Axin_b-cat_bind activity, induced 10581160 2 9 6 Phosphorylation plays a role in the activation of axin to modulate Lef/Tcf signaling. Phosphorylation by GSK3beta also leads to increased direct binding of beta-catenin in vitro. +HMGB1 HMGB1 DNA repair, damage; Nuclear receptor co-regulator P09429 3146 13q12.3 human S46-p 33673900 SEFSKKCsERWKTMS HMG_box_2 intracellular localization 24863048 1 0 0 localization into the cytosol +LEPR LEPR Membrane protein, integral; Receptor, cytokine P48357 3953 1p31.3 human Y1141-p 448434 SKKTFASyMPQFQTC transcription, induced; signaling pathway regulation 17726024; 20868760 16 0 0 mediates STAT3 phosphorylation and FZD1 expression +Pde6g PDE6G EC 3.1.4.35; Nucleotide Metabolism - purine; Phosphodiesterase P09174 18588 11 E2|11 84.14 cM mouse T62-p 449335 PGMEGLGtDITVICP PDE6_gamma activity, induced; molecular association, regulation; phosphorylation GRK2(INDUCES) 11502744; 12624098 2 0 0 leads to greater phospho-ERK; increases ERK phosphorylation +FYB1 SLAP-130 Adaptor/scaffold O15117 2533 5p13.1 human Y571-p 454079 TTAVEIDyDSLKLKK molecular association, regulation; intracellular localization; phosphorylation cell motility, induced; cell motility, altered; transcription, induced ZAP70(INDUCES) 20661443; 26246585; 33431658 3 31 774 after CXCR4 stimulation; induces STAT3 phosphorylation; promotes cell migration +Bmal1 BMAL1 iso4 DNA-binding; Transcription factor Q9WTL8-4 11865 7 F1|7 59.17 cM mouse S90-p 7359500 RRRDKMNsFIDELAS HLH molecular association, regulation CK2B(DISRUPTS) 26562092 3 0 0 inhibits CK2A1 binding and phosphorylation, regulates the central and peripheral clocks +RUNX2 AML3 DNA-binding; Transcription factor Q13950 860 6p21.1 human S465-p 460684 MVPGGDRsPSRMLPP RunxI molecular association, regulation cell cycle regulation; cell motility, induced; cell growth, induced; cell differentiation, induced; transcription, altered; cell growth, altered DNA(INDUCES) 16407259; 21913213 5 0 0 +CASS4 HEFL Adaptor/scaffold Q9NQ75 57091 20q13.31 human Y350-p 458181 QNTKPNIyDIPKATS molecular association, regulation Arg(NOT_REPORTED) 23322602 0 5 341 +H2AZ2 H2AFV Q71UI9 94239 7p13 human K7-ac 480255 _AGGKAGkDSGKAKA Histone molecular association, regulation transcription, induced FALZ(INDUCES) 32356653 1 10 321 K7ac preferentially engaging the binding site, acetylation at K7ac and K13ac is also the highest-affinity acetylation pattern of isoform I +ADRB1 ADRB1 GPCR, family 1; Membrane protein, integral; Membrane protein, multi-pass; Receptor, GPCR P08588 153 10q25.3 human S461-p 89117901 GAAADSDsSLDEPCR receptor internalization, induced; molecular association, regulation; intracellular localization ARRB1(INDUCES) 28472170 1 2 0 beta-arrestin recruitment to the ADRB1 +CENPT CENPT DNA replication Q96BT3 80152 16q22.1 human S47-p 11141604 RALLETAsPRKLSGQ CENP-T_N intracellular localization cell cycle regulation 21529714 2 14 2 localization of Ndc80/Hec1, controls kinetochore assembly, increases cell viability +ARMC10 ARMC10 Endoplasmic reticulum; Membrane protein, integral Q8N2F6 83787 7q22.1 human S45-p 454558 LGIRSSKsAGALEEG activity, induced autophagy, induced 30631047 1 72 18 regulates AMPK-mediated mitochondrial dynamics and fission +CNKSR1 CNK1 Adaptor/scaffold; G protein regulator, misc. Q969H4 10256 1p36.11 human S22-p 59070501 WLRGLDDsLQDYPFE SAM_1 molecular association, regulation; protein conformation cell growth, induced Akt1(INDUCES) 27769899 1 1 0 oligomerization, invasion of cancer cells +DDR2 DDR2 EC 2.7.10.1; KINASE; Kinase, protein; Membrane protein, integral; Protein kinase, TK; Protein kinase, tyrosine (receptor) Q16832 4921 1q23.3 human Y740-p 456862 RNLYSGDyYRIQGRA PK_Tyr_Ser-Thr phosphorylation 16186108 2 9 366 Stimulates autophosphorylation. Autophosphorylation induces Shc binding (site not determined). +ANXA2 ANXA2 Calcium-binding; Lipid-binding; Motility/polarity/chemotaxis P07355 302 15q22.2 human S12-p 450880 HEILCKLsLEGDHST molecular association, regulation; intracellular localization exocytosis, inhibited S100A10(DISRUPTS) 11106498; 12962548; 21115493; 23757730 7 29 1 regulates VWF secretion +KCNA3 Kv1.3 Channel, potassium; Membrane protein, integral; Membrane protein, multi-pass P22001 3738 1p13.3 human Y161-p 3820926 PSFDAILyYYQSGGR BTB_2 activity, inhibited 19166614 1 0 0 +HCRTR1 HCRTR1 GPCR, family 1; Membrane protein, integral; Membrane protein, multi-pass; Receptor, GPCR O43613 3061 1p35.2 human Y358-p 2063600 SAANPIIyNFLSGKF 7tm_1; TM apoptosis, induced 18198212 1 0 0 apoptosis is inhibited in cells transfected with dnSHP-2 cDNA or treated with PAO +GLI1 GLI1 C2H2-type zinc finger protein; Oncoprotein; Transcription factor P08151 2735 12q13.3 human S1078-p 1034327202 SGHTPPPsGPPNMAV molecular association, regulation; intracellular localization transcription, inhibited SUFU(INDUCES) DNA(DISRUPTS) 29662197 1 0 0 localized in cytoplasm +FER Fer EC 2.7.10.2; KINASE; Kinase, protein; Oncoprotein; Protein kinase, TK; Protein kinase, tyrosine (non-receptor) P16591 2241 5q21.3 human Y615-p 6311907 EAKILKQyDHPNIVK PK_Tyr_Ser-Thr enzymatic activity, induced 19159681 1 0 1 +Notch2 Notch 2 KINASE; Kinase, protein; Membrane protein, integral; Motility/polarity/chemotaxis; Receptor, misc. Q9QW30 29492 2q34 rat S2090-p 2154600 VLCGPNRsFLSLKHT activity, induced cell differentiation, altered; transcription, altered 11577080 1 1 0 +H1-4 H1E DNA-binding P10412 3008 6p22.2 human S187-p 458354 KPKKAPKsPAKAKAV molecular association, regulation transcription, induced POLR2A(INDUCES) DNA(INDUCES) 33238524 2 20 57 +MYL9 MRLC1 Contractile; Motility/polarity/chemotaxis P24844 10398 20q11.23 human S3-p 4964100 _____MSsKRAKAKT intracellular localization cytoskeletal reorganization 22136066 5 0 0 +GHSR GHSR GPCR, family 1; Membrane protein, integral; Membrane protein, multi-pass; Receptor, GPCR Q92847 2693 3q26.31 human T261-p 25293461 RDQNHKQtVKMLAVV 7tm_1 molecular association, regulation ARRB1(INDUCES); ARRB2(INDUCES) 35605660 1 0 1 +NR4A2 NR4A2 DNA-binding; Nuclear receptor P43354 4929 2q24.1 human S181-p 30304800 SLFSFKQsPPGTPVS intracellular localization 24223135 1 4 0 UV induced nuclear foci formation and co-localization with DNA repair proteins +TERF2 TRF2 DNA repair, damage; DNA-binding Q15554 7014 16q22.1 human T230-p 456963 HMSKDPTtQKLRNDL TRF intracellular localization 16223874 3 1 0 TRF2 T188 localizes to telomeres iin crisis and associates with Double stranded breaks in photo-induced cells. +CANX Calnexin Calcium-binding; Endoplasmic reticulum; Membrane protein, integral; Motility/polarity/chemotaxis P24643 dog S565-p 456360 EEDGGTAsQEEDDRK molecular association, regulation; intracellular localization PACS2(DISRUPTS) 18417615 7 85 48 +Ppp1r9b Spinophilin Adaptor/scaffold; Protein phosphatase, regulatory subunit Q6R891 217124 11|11 D mouse S15-p 455339 GPGGPLRsASPHRSA cytoskeletal reorganization 15728359 1 0 0 +Irs1 IRS1 Adaptor/scaffold; Motility/polarity/chemotaxis P35570 25467 9q34 rat S612-p 447562 DDGYMPMsPGVAPVP molecular association, regulation; enzymatic activity, inhibited PIK3R2(DISRUPTS); PIK3R1(DISRUPTS) 16354680; 8626671 37 7 4 +RPS10 RPS10 Nucleolus; RNA-binding; Ribosomal; Translation P46783 6204 6p21.31 human K139-ub 486966 VPPGADKkAEAGAGS translation, altered 32324387 2 11 138 translational read-through of poly(A) mRNA sequence (KAAA) 20, ZNF598 plays a role in this process +LCOR LCOR iso3 Nuclear receptor co-regulator Q96JN0-3 84458 10q24.1 human K1241-m3 1881561800 RLKKHLKkFPGATPA molecular association, regulation; enzymatic activity, induced 34321472 1 1 0 LCOR K1241 is required in order to enhance the HMTase activity of PRC2, binds to the aromatic cage of the regulatory subunit EED to stimulate PRC2 +ZKSCAN3 ZNF306 C2H2-type zinc finger protein; DNA-binding; Transcription factor Q9BRR0 80317 6p22.1 human K148-ac 1881852002 GQELLCCkMALLTPA intracellular localization autophagy, inhibited; transcription, inhibited 35124181 1 0 0 translocate to nucleus, autophagy-lysosomal inhibition +LRRK2 LRRK2 EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, Ser/Thr (non-receptor); Protein kinase, TKL Q5S007 120892 12q12 human S910-p 4725893 LVKKKSNsISVGEFY protein stabilization; molecular association, regulation; ubiquitination; enzymatic activity, inhibited; intracellular localization; phosphorylation 14-3-3 beta(INDUCES); 14-3-3 sigma(INDUCES); 14-3-3 theta(INDUCES); 14-3-3 zeta(INDUCES); 14-3-3 epsilon(INDUCES); 14-3-3 gamma(INDUCES); 14-3-3 eta(INDUCES) 20642453; 20659021; 21378983; 22004453; 24942733; 25009464; 32317922; 34144124; 35266954 22 17 0 +Mapk10 JNK3 EC 2.7.11.24; KINASE; Kinase, protein; Protein kinase, CMGC; Protein kinase, Ser/Thr (non-receptor) P49187 25272 14p22 rat T131-p 448033 ISLLNVFtPQKTLEE Pkinase apoptosis, induced 11823425 1 0 0 +Cebpb C/EBP-beta DNA-binding; Motility/polarity/chemotaxis; Transcription factor P28033 12608 2 H3|2 87.58 cM mouse K211-ac 1881371303 GPPAAPAkAKAKKTV protein degradation 34642310 1 1 0 SIRT2 decreases acetylation and ubiquitylation (not at K102 site) ; under ethanol stress +Camk2b CAMK2B EC 2.7.11.17; KINASE; Kinase, protein; Protein kinase, CAMK; Protein kinase, Ser/Thr (non-receptor) P08413 24245 14q21 rat T381-p 2020833 PAALEPQtTVIHNPV molecular association, regulation 26291163 1 2 1 inhibits interaction with F-actin, regulates synaptic plasticity +Lrp6 LRP6 Membrane protein, integral; Receptor, misc. O88572 16974 6 G1|6 65.37 cM mouse T1572-p 3802448 EPVPPPPtPRSQYLS signaling pathway regulation 24692544 5 0 8 Wnt signaling +Ctnnd1 CTNND1 Actin-binding; Adaptor/scaffold; Cell adhesion; G protein regulator, misc.; Motility/polarity/chemotaxis P30999 12388 2 D|2 49.45 cM mouse Y112-p 472275 PGQIVETyTEEDPEG molecular association, regulation cytoskeletal reorganization RHOA(DISRUPTS); CDH1(INDUCES) 17194753 3 0 0 resposible for the dendritic phenotype in fibroblasts; decreases the amount of active RhoA +RUNX1 AML1 DNA-binding; Oncoprotein; Transcription factor Q01196 861 21q22.12 human S249-p 454399 DTRQIQPsPPWSYDQ activity, induced; molecular association, regulation; phosphorylation transcription, altered; cell growth, altered CBFB(INDUCES) 18695000; 8668214 10 8 46 +ERBB4 HER4 EC 2.7.10.1; KINASE; Kinase, protein; Membrane protein, integral; Protein kinase, TK; Protein kinase, tyrosine (receptor) Q15303 2066 2q34 human S1051-p 1869951802 NRSEIGHsPPPAYTP enzymatic activity, inhibited signaling pathway regulation 31053301 1 0 0 MEK-ERK pathway-dependent feedback inhibition of HER4 activation +FGFR2 FGFR2 EC 2.7.10.1; KINASE; Kinase, protein; Membrane protein, integral; Oncoprotein; Protein kinase, TK; Protein kinase, tyrosine (receptor) P21802 2263 10q26.13 human Y657-p 472825 DINNIDYyKKTTNGR PK_Tyr_Ser-Thr carcinogenesis, induced; cell growth, induced 35428876 2 6 36 +Fis1 FIS1 Membrane protein, integral; Mitochondrial Q9CQ92 66437 5|5 G2 mouse T34-p 1876807204 AGSVSKStQFEYAWC Fis1_TPR_N molecular association, regulation; intracellular localization apoptosis, induced DRP1(INDUCES) 35290083 1 0 0 +WDR62 WDR62 Adaptor/scaffold O43379 284403 19q13.12 human T50-p 1246205 RRRTRLStASEETVQ cell cycle regulation 25501809; 26713495 2 16 213 WDR62 regulation of the mitotic spindle; S49/T50 is critical for spindle alignment and mitotic integrity; microtubule association +SH2D2A TSAd Adaptor/scaffold Q9NP31 9047 1q23.1 human Y290-p 449441 PDEPIAFyAMGRGSP molecular association, regulation Lck(INDUCES) 18541536 1 3 129 +PIP5K1C PIP5K1C Carbohydrate Metabolism - inositol phosphate; EC 2.7.1.68; Kinase, lipid; Motility/polarity/chemotaxis O60331 23396 19p13.3 human Y639-p 486321 DAPATDIyFPTDERS carcinogenesis, induced; cell motility, induced; cell growth, induced 25486426 3 0 0 Establishment of tumor favorable microenvironment +BCR/ABL BCR-ABL1 EC 2.7.10.2; Fusion protein; KINASE; Kinase, protein; Protein kinase, TK; Protein kinase, tyrosine (non-receptor) A9UF07 human Y177-p 22639318 ADAEKPFyVNVEFHH molecular association, regulation cell growth, induced; transcription, induced GRB2(INDUCES) 8402896 1 3 6 transcription from ets/AP1 +EGFR EGFR EC 2.7.10.1; KINASE; Kinase, protein; Membrane protein, integral; Oncoprotein; Protein kinase, TK; Protein kinase, tyrosine (receptor) P00533 1956 7p11.2 human K754-ub 1065303 LREATSPkANKEILD PK_Tyr_Ser-Thr receptor recycling, inhibited; protein degradation 16543144; 17940017 2 3 0 +NOS3 eNOS Amino Acid Metabolism - arginine and proline; EC 1.14.13.39; Oxidoreductase Q7YSG7 397557 pig T497-p 447885 TGIARKKtFKEVANA enzymatic activity, inhibited 15333638 82 2 1 +NCOA3 SRC-3 ACETYLTRANSFERASE; Acetyltransferase; EC 2.3.1.48; Motility/polarity/chemotaxis; Nuclear receptor co-regulator; Transcription, coactivator/corepressor Q9Y6Q9 8202 20q13.12 human S1033-p 4252802 NRPLLRNsLDDLVGP protein stabilization; molecular association, regulation PSMA3(DISRUPTS) 18313384 1 4 0 some subset of these 8 residues +BTRC BTRC Motility/polarity/chemotaxis; UBIQUITIN LIGASE; Ubiquitin conjugating system; Ubiquitin ligase Q9Y297 8945 10q24.32 human S158-p 1872610002 EFVEHLIsQMCHYQH Beta-TrCP_D protein degradation; protein stabilization; molecular association, regulation; ubiquitination cell cycle regulation; DNA repair, induced FBW1B(INDUCES) 33676897 1 0 0 induces stabilization of itself and regulates ubiquitination and degradation of BTRC2 and MDM2 and stabilization of p53 +Mapt Tau ACETYLTRANSFERASE; Acetyltransferase; Cytoskeletal P19332 29477 10q32.1 rat T492-p 447932 KTTPSPKtPPGSGEP neural plasticity 33648608 107 36 23 +LCOR LCOR iso3 Nuclear receptor co-regulator Q96JN0-3 84458 10q24.1 human K1241-m2 1881559702 RLKKHLKkFPGATPA molecular association, regulation; enzymatic activity, induced 34321472 1 1 0 LCOR K1241 is required in order to enhance the HMTase activity of PRC2, binds to the aromatic cage of the regulatory subunit EED to stimulate PRC2 +EEF2K EEF2K EC 2.7.11.20; KINASE; Kinase, protein; Protein kinase, Ser/Thr (non-receptor); Protein kinase, atypical; Translation O00418 29904 16p12.2 human Y69-p 1877127902 NLTKSERySSSGSPA enzymatic activity, inhibited carcinogenesis, induced; cell growth, induced; translation, induced 35513296 0 1 0 +STIM1 STIM1 Calcium-binding; Endoplasmic reticulum; Membrane protein, integral Q13586 6786 11p15.4 human S668-p 484156 IGEETDSsPGRKKFP molecular association, regulation; intracellular localization; activity, inhibited cytoskeletal reorganization EB1(DISRUPTS) 19881501; 22748319 4 22 3 phosphorylation dissociates STIM1 from EB1 during mitosis, and excludes ER from the mitotic spindle; involved in suppression of store-operated calcium entry during mitosis +Epha4 EphA4 EC 2.7.10.1; KINASE; Kinase, protein; Membrane protein, integral; Protein kinase, TK; Protein kinase, tyrosine (receptor) Q03137 13838 1 C4|1 39.55 cM mouse Y928-p 450651 QAIKMDRyKDNFTAA SAM_2 activity, inhibited cell adhesion, altered 14742708 1 0 0 +Kdr VEGFR2 EC 2.7.10.1; KINASE; Kinase, protein; Membrane protein, integral; Protein kinase, TK; Protein kinase, tyrosine (receptor) P35918 16542 5 C3.3|5 40.23 cM mouse Y1212-p 447902 VCDPKFHyDNTAGIS molecular association, regulation; phosphorylation; enzymatic activity, induced Src(INDUCES) 12023952; 15107818 17 4 58 +CERS5 LASS5 DNA-binding; EC 2.3.1.24; Membrane protein, integral; Membrane protein, multi-pass; Transferase Q8N5B7 91012 12q13.12 human S356-p 18260888 RSDVESSsEEEDVTT enzymatic activity, induced 26887952 1 6 0 +TARBP2 TRBP Motility/polarity/chemotaxis; RNA processing; RNA-binding; Translation Q15633 6895 12q13.13 human S283-p 27457469 ILSLRSCsLGSLGAL protein stabilization; molecular association, regulation transcription, induced P70S6KB(DISRUPTS) 27407113 1 6 0 optimal TRBP expression in human primary cells; miRNA expression +LIN9 LIN9 Cell cycle regulation; Transcription, coactivator/corepressor; Tumor suppressor Q5TKA1 286826 1q42.12 human T96-p 3201645 KFTATMStPDKKASQ cell cycle regulation; transcription, induced 24475316 2 9 15 +SSTR2 SSTR2 GPCR, family 1; Membrane protein, integral; Membrane protein, multi-pass; Receptor, GPCR P30874 6752 17q25.1 human T356-p 12577701 RLNETTEtQRTLLNG receptor internalization, induced; receptor desensitization, induced; receptor recycling, induced 24565897; 24637622 6 0 0 +SERPINA3 SERPINA3 Secreted; Secreted, signal peptide P01011 12 14q32.13 human K236-ac 464673 SRFYLSKkKWVMVPM Serpin molecular association, regulation DNA(INDUCES) 7782318 1 0 0 +Banp BANP Tumor suppressor Q8VBU8 53325 8 E1|8 70.82 cM mouse S370-p 36440208 PTSELQQsQPQALHY molecular association, regulation; intracellular localization cell cycle regulation; DNA repair, induced; apoptosis, inhibited H2AX(INDUCES) 25299772 1 0 0 +Crk CRK Adaptor/scaffold; Motility/polarity/chemotaxis; Oncoprotein Q63768 54245 10q24 rat Y221-p 447951 GGPEPGPyAQPSVNT molecular association, regulation EGFR(DISRUPTS) 9642287 25 14 1168 +SUZ12 SUZ12 C2H2-type zinc finger protein; Oncoprotein; Transcription factor Q15022 23512 17q11.2 human S583-p 4170593 PQEMEVDsEDEKDPE VEFS-Box molecular association, regulation; protein conformation; enzymatic activity, induced cell differentiation, altered; transcription, inhibited H3(INDUCES) DNA(INDUCES) 36351927 1 25 0 induces histone methylation +DCTN1 dynactin 1 Microtubule-binding; Motility/polarity/chemotaxis; Motor Q14203 1639 2p13.1 human S19-p 455515 TPSGSRMsAEASARP intracellular localization cytoskeletal reorganization 23547029 2 1 0 accumulation at spindle poles, required for central spindle assembly +APPL1 APPL Adaptor/scaffold; Nuclear receptor co-regulator Q9UKG1 26060 3p14.3 human S430-p 13204434 ARTSSSGsLGSESTN signaling pathway regulation 22685300 1 2 0 mediates stress-induced insulin resistance +WEE2 WEE1B EC 2.7.10.2; KINASE; Kinase, protein; Protein kinase, Other; Protein kinase, Ser/Thr (non-receptor); Protein kinase, tyrosine (non-receptor) A4PES0 pig S77-p 20473608 PQVKDRAsPDQGLRT intracellular localization; enzymatic activity, induced cell cycle regulation 21123961 1 0 0 +Csf3r GCSFR Membrane protein, integral; Receptor, cytokine P40223 12986 4 D2.2|4 59.77 cM mouse Y768-p 451835 TSPGVMQyIRSDSTQ activity, induced; molecular association, regulation 29572350 5 0 0 STAT3 activation +Rab10 RAB10 G protein; G protein, monomeric; G protein, monomeric, Rab P61027 19325 12 A1.1|12 1.71 cM mouse T73-p 471953 AGQERFHtITTSYYR Ras autophagy, induced; apoptosis, induced; autophagy, inhibited; signaling pathway regulation 37269951; 37454104 18 13 13 +Rb1 Rb Nuclear receptor co-regulator; Oncoprotein; Transcription, coactivator/corepressor; Tumor suppressor P13405 19645 14 38.73 cM|14 D3 mouse T367-p 447982 ANVVTPHtPVRTVMN RB_A molecular association, regulation E2F1(DISRUPTS) 10207050 10 51 40 +PRKCB PKCB EC 2.7.11.13; KINASE; Kinase, protein; Motility/polarity/chemotaxis; Protein kinase, AGC; Protein kinase, Ser/Thr (non-receptor) P05771 5579 16p12.2-p12.1 human S661-p 448672 QNEFAGFsYTNPEFV Pkinase_C intracellular localization; phosphorylation; enzymatic activity, induced transcription, induced 17504762; 35835217 12 1 0 +EHMT2 EHMT2 Amino Acid Metabolism - lysine degradation; EC 2.1.1.43; METHYLTRANSFERASE; Methyltransferase; Methyltransferase, protein lysine Q96KQ7 10919 6p21.33 human K361-sm 1878097302 KPSRKRRkREPPRAK molecular association, regulation; intracellular localization cell cycle regulation; cell growth, induced; transcription, induced PCAF(INDUCES) 30867409 1 0 0 SUMOylated G9a is recruited to E2F1 target gene promoters, EHMT2 is an activator of proliferation and E2F1-target gene expression +PRKAR2B PKAR2B Mitochondrial; Protein kinase, regulatory subunit P31323 5577 7q22.3 human S114-p 452036 NRFTRRAsVCAEAYN protein degradation; enzymatic activity, inhibited; intracellular localization; phosphorylation neural plasticity; transcription, altered 15187164; 33608270; 33649504 5 69 173 inhibits CREB phosphorylation +PAK5 PAK5 EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, STE; Protein kinase, Ser/Thr (non-receptor) Q9P286 57144 20p12.2 human S288-p 1878257802 TMRQRSRsGSGLQEP molecular association, regulation; intracellular localization 14-3-3 sigma(INDUCES) 35969127 1 0 0 +KCNQ1 Kv7.1 Channel, potassium; Membrane protein, integral; Membrane protein, multi-pass P51787 3784 11p15.5-p15.4 human S464-p 456163 SVDGYDSsVRKSPTL activity, induced 12879210 1 1 0 +CGAS cGAS EC 2.7.7.86 Q8N884 115004 6q13 human K384-sm 62952702 LSFSHIEkEILNNHG Mab-21 enzymatic activity, inhibited transcription, inhibited; signaling pathway regulation DNA(DISRUPTS) 28095500 1 0 0 regulation of STING signaling pathway +Met Met EC 2.7.10.1; KINASE; Kinase, protein; Membrane protein, integral; Oncoprotein; Protein kinase, TK; Protein kinase, tyrosine (receptor) P16056 17295 6 A2|6 7.83 cM mouse Y1347-p 448472 STFIGEHyVHVNATY molecular association, regulation cell differentiation, induced; cell motility, altered; cytoskeletal reorganization GRB2(INDUCES); PIK3C2A(INDUCES); GAB1(INDUCES); SHC1(INDUCES) 10069803; 37175792; 7708691 30 6 125 activates cell mobility +MYC Myc DNA-binding; Nucleolus; Oncoprotein; Transcription factor P01106 4609 8q24.21 human K163-ac 460638 AAKLVSEkLASYQAA Myc_N protein stabilization transcription, induced 33928666 4 8 35 +CLSPN claspin Actin-binding; Cell cycle regulation Q9HAW4 63967 1p34.3 human S30-p 467250 EADSPSDsGQGSYET protein degradation; molecular association, regulation cell cycle regulation BTRC(INDUCES) 16885022 1 0 0 claspin degradation is necessary for termination of the DNA replication checkpoint. +CDK5R1 CDK5R1 Protein kinase, regulatory subunit Q15078 8851 17q11.2 human S8-p 471392 MGTVLSLsPSYRKAT molecular association, regulation; protein stabilization; intracellular localization; protein conformation; enzymatic activity, induced cytoskeletal reorganization 17121855; 20976519; 22467861; 26469698 7 0 1 augments its F-actin bundling activity, disrupts microtubule binding +ESR2 ER-beta DNA-binding; Nuclear receptor Q92731 2100 14q23.2-q23.3 human S176-p 23068600 CKAFFKRsIQGHNDY zf-C4 molecular association, regulation transcription, induced DNA(DISRUPTS) 22266331; 34147032 2 1 0 +Trpv1 TRPV1 Channel, cation; Membrane protein, integral; Membrane protein, multi-pass; Receptor, misc. O35433 83810 10q24 rat S502-p 450016 YFLQRRPsLKSLFVD Ion_trans activity, induced; receptor desensitization, inhibited; receptor desensitization, altered RNUXA(INDUCES) 12761211; 14523239; 14630912; 14973326; 15003856; 15375192; 18495351; 22933780; 32345612; 33180962 19 0 0 +RCE1 RCE1 iso2 EC 3.4.22.-; Membrane protein, integral; Membrane protein, multi-pass; Protease A0A024R5B6 9986 11q13.2 human K43-ub 40190211 CDLADGLkVVLAPRS Rce1-like protein stabilization; intracellular localization cell growth, inhibited 24134311 1 0 0 +Dab1 DAB1 Adaptor/scaffold P97318 13131 4 C6|4 47.79 cM mouse Y220-p 447630 PETEENIyQVPTSQK molecular association, regulation; intracellular localization neural plasticity; cell differentiation, induced; cell motility, altered; cell adhesion, altered; cytoskeletal reorganization; cell growth, altered Src(INDUCES); CRKL(INDUCES); SOCS1(INDUCES); NCK2(INDUCES); CRK(INDUCES); PIK3R1(INDUCES) 14517291; 15062102; 15091337; 15110774; 19796633; 22586277 12 2 0 alternatively spliced variants +USP20 USP20 DEUBIQUITINASE; EC 3.4.19.12; Protease; Ubiquitin conjugating system; Ubiquitin-specific protease Q9Y2K6 10868 9q34.11 human S333-p 7323248 RMKDRKFsWGQQRTN molecular association, regulation; ubiquitination; enzymatic activity, inhibited ADRB2(DISRUPTS) 25666616 3 13 18 regulates lysosomal trafficking and ubiquitination of ADRB2 +Ccnt1 CCNT1 Cell cycle regulation; Transcription initiation complex Q9QWV9 12455 15|15 F1 mouse K380-ac 25174701 GSQKQASkSVPSAKV molecular association, regulation; enzymatic activity, induced transcription, induced BCDIN3(DISRUPTS); HEXIM1(DISRUPTS) 19387490 3 1 0 enhances CDK9/cyclin T1 transcriptional activity, disrupting HEXIM1 and BCDIN3 association +DYRK1A DYRK1A EC 2.7.12.2; KINASE; Kinase, protein; Protein kinase, CMGC; Protein kinase, dual-specificity (non-receptor) Q13627 1859 21q22.13 human Y145-p 449566 DGYDDDNyDYIVKNG intracellular localization cell cycle regulation; cell differentiation, altered 21878370 1 30 877 +USP33 USP33 DEUBIQUITINASE; EC 3.4.19.12; Protease; Ubiquitin conjugating system; Ubiquitin-specific protease Q8TEY7 23032 1p31.1 human T185-p 1883930900 ELRARGLtGLKNIGN receptor desensitization, induced; ubiquitination 36658650 1 0 0 mediates deubiquitination of arrestin 3 +ESRRA ERR1 DNA-binding; Nuclear receptor; Transcription regulation P11474 2101 11q13.1 human K138-ac 15211510 CQACRFTkCLRVGML zf-C4 molecular association, regulation transcription, inhibited DNA(DISRUPTS) 20484414 1 1 0 +MLH1 MLH1 Cell cycle regulation; DNA repair, damage; Tumor suppressor P40692 4292 3p22.2 human K33-ub 573763746 QRPANAIkEMIENCL HATPase_c_3 molecular association, regulation MSH2(INDUCES); MSH6(INDUCES) 30770470 1 3 0 +NONO NONO Nuclear receptor co-regulator; Nucleolus; RNA splicing; RNA-binding Q15233 4841 Xq13.1 human R251-m2 1881147400 NQQFHKErEQPPRFA carcinogenesis, induced; cell motility, induced; cell growth, induced 33420374 1 1 0 +Bmal1 BMAL1 DNA-binding; Transcription factor Q9WTL8 11865 7 F1|7 59.17 cM mouse S521-p 1878257204 RIRGSSPsSCGSSPL activity, induced transcription, induced 35902736 1 1 0 +PDE4A PDE4A EC 3.1.4.53; Nucleotide Metabolism - purine; Phosphodiesterase P27815 5141 19p13.2 human S145-p 458389 ATSQRREsFLYRSDS enzymatic activity, induced 12023945 4 20 1 +Mavs MAVS Adaptor/scaffold; Membrane protein, integral Q8VCF0 228607 2|2 F1 mouse S330-p 143281204 PSKLPSNsVYAGTVP transcription, induced 28725479 1 1 0 +KLF10 KLF10 C2H2-type zinc finger protein; DNA-binding; Transcription factor Q13118 7071 8q22.3 human S384-p 5263526 GKTYFKSsHLKAHTR molecular association, regulation; intracellular localization DNA(DISRUPTS) 20953893 1 0 1 +DOK1 DOK1 Adaptor/scaffold; Motility/polarity/chemotaxis Q99704 1796 2p13.1 human Y398-p 448369 ARVKEEGyELPYNPA molecular association, regulation; phosphorylation RASA1(INDUCES); NCK1(INDUCES) 11551902 4 15 547 +CFLAR CFLAR Apoptosis O15519 8837 2q33.1 human K195-ub 40245511 AAIQKSLkDPSNNFR protein degradation apoptosis, induced 23559011; 24013390 3 3 0 +HDAC1 HDAC1 DEACETYLASE; Deacetylase; EC 3.5.1.98; Hydrolase; Nuclear receptor co-regulator P56517 373961 chicken S415-p 1872055900 RNSDKRIsCDEEFSD protein stabilization; molecular association, regulation transcription, induced MBD3(DISRUPTS); HDAC2(INDUCES); MTA1(DISRUPTS) 33596269 1 0 0 no effect on homodimerization +FASN FASN ACETYLTRANSFERASE; Acetyltransferase; EC 1.1.1.100; EC 1.3.1.39; EC 2.3.1.38; EC 2.3.1.39; EC 2.3.1.41; EC 2.3.1.85; EC 3.1.2.14; EC 4.2.1.59; Hydrolase; Lipid Metabolism - fatty acid biosynthesis; Lyase; Oxidoreductase P49327 2194 17q25.3 human S1028-p 27930800 LWKDNWVsFMDTMLQ PS-DH transcription, inhibited 23585690 1 2 0 +JAK2 JAK2 EC 2.7.10.2; KINASE; Kinase, protein; Oncoprotein; Protein kinase, TK; Protein kinase, tyrosine (non-receptor) O60674 3717 9p24.1 human Y972-p 470145 EYLGTKRyIHRDLAT PK_Tyr_Ser-Thr activity, induced signaling pathway regulation 23926298 3 1 0 oncogenic kinase Jak2V617F signaling and tumor suppressor (PP2A) activity +OGG1 OGG1 DNA repair, damage; Deoxyribonuclease; EC 4.2.99.18; Lyase O15527 4968 3p25.3 human S231-p 10036106 WLQQLREsSYEEAHK HhH-GPD enzymatic activity, inhibited 19674107 1 0 0 +CAPN2 CAPN2 EC 3.4.22.53; Motility/polarity/chemotaxis; Protease P17655 824 1q41 human S50-p 451162 GTLFQDPsFPAIPSA Peptidase_C2 activity, induced cell motility, altered; cell adhesion, altered 14993287; 26248159 3 1 0 +RAD9A RAD9A Apoptosis; Cell cycle regulation; DNA replication; Deoxyribonuclease; EC 3.1.11.2 Q99638 5883 11q13.2 human S336-p 449816 PGPQPPKsPGPHSEE cell cycle regulation 12734188; 20305300 3 7 10 +Agtr1 AT1 GPCR, family 1; Membrane protein, integral; Membrane protein, multi-pass; Receptor, GPCR P25095 24180 17p12 rat T332-p 467239 KSHSSLStKMSTLSY molecular association, regulation ARRB2(INDUCES) 29146594 3 0 0 BRET +PFKFB2 PFKFB2 Carbohydrate Metabolism - fructose and mannose; EC 2.7.1.105; EC 3.1.3.46; Kinase, other; Motility/polarity/chemotaxis; Phosphatase (non-protein) P26285 287019 cow S484-p 452046 IRRPRNYsVGSRPLQ enzymatic activity, induced 9211863 8 36 101 +TERT TERT iso3 DNA-binding; EC 2.7.7.49; Nucleolus; Transferase O14746-3 7015 5p15.33 human K338-ub 14561004 FLYSSGDkEQLRPSF protein degradation chromatin organization, altered; apoptosis, induced 20453884 1 0 0 +POU5F1 Oct4 DNA-binding; Transcription factor Q01860 5460 6p21.33 human T235-p 15502889 QARKRKRtSIENRVR Homeodomain molecular association, regulation transcription, inhibited DNA(DISRUPTS) 22474382 2 1 1 +ZAP70 ZAP70 EC 2.7.10.2; KINASE; Kinase, protein; Protein kinase, TK; Protein kinase, tyrosine (non-receptor) P43403 7535 2q11.2 human Y493-p 447505 LGADDSYyTARSAGK PK_Tyr_Ser-Thr activity, induced; phosphorylation; enzymatic activity, induced cell differentiation, induced; cell adhesion, altered; transcription, altered; signaling pathway regulation 11514606; 11976341; 15100278; 30992398; 33482200; 7642520; 7781602; 8756661 28 13 427 increases Ca(2+) mobilization and Ras activation +Mta1 MTA1 Motility/polarity/chemotaxis; Nuclear receptor co-regulator; Transcription, coactivator/corepressor Q8K4B0 116870 12|12 F1 mouse K626-ac 460693 RNLLLNGkSYPTKVR molecular association, regulation transcription, induced POLR2A(INDUCES) 17671180 2 0 0 Pax5 transcription +FLRT1 FLRT1 Cell adhesion; Membrane protein, integral; Motility/polarity/chemotaxis Q9NZU1 23769 11q13.1 human Y600-p 14150102 GSRKKDDyMESGTKK TM intracellular localization cell growth, altered 20421966 1 0 0 regulates ERK1/2 activation +PXN PXN Adaptor/scaffold; Cell adhesion; Cytoskeletal; Motility/polarity/chemotaxis P49023 5829 12q24.23 human S178-p 448603 PPLPGALsPLYGVPE Paxillin cell motility, altered; cytoskeletal reorganization; cell adhesion, altered 12853963 9 2 0 +SNAI2 Snail2 Apoptosis; C2H2-type zinc finger protein; Motility/polarity/chemotaxis; Transcription factor O43623 6591 8q11.21 human S158-p 1162843400 CDAQSRKsFSCKYCD activity, induced; protein stabilization; ubiquitination; intracellular localization carcinogenesis, induced; transcription, inhibited 29849120 2 0 0 induces transcriptional repressor activity, inhibits ubiquitination +Kcnb1 Kv2.1 Channel, cation; Channel, ligand-gated; Channel, potassium; Membrane protein, integral; Membrane protein, multi-pass Q03717 16500 2 H3|2 87.22 cM mouse S567-p 473554 LEMGSMPsPVAPLPT Kv2channel activity, induced 24962901 6 6 0 +PAGE4 PAGE4 Cancer Testis Antigen (CTA) O60829 9506 Xp11.23 human T51-p 3913886 PGQEREGtPPIEERK GAGE protein degradation; molecular association, regulation; protein conformation transcription, induced Jun(DISRUPTS) 24559171; 26242913 2 6 7 +Tmbim1 TMBIM1 Membrane protein, integral; Membrane protein, multi-pass Q8BJZ3 69660 1|1 C3 mouse K275-ub 1873041108 QLVLGNRkHTISPED Bax1-I molecular association, regulation Hrs(INDUCES) 28481357 1 1 0 +SPI1 PU.1 DNA-binding; Oncoprotein; Transcription factor P17947 6688 11p11.2 human S41-p 13421401 EYYPYLSsDGESHSD protein degradation; molecular association, regulation; ubiquitination cell differentiation, inhibited FBXW7(INDUCES) 33188146 2 0 0 +GATA2 GATA2 Transcription factor P23769 2624 3q21.3 human K419-ub 1883354002 ECFEELSkCMQEKSS cell growth, inhibited 36251994 1 0 0 +CDH5 CDH5 Cell adhesion; Membrane protein, integral; Motility/polarity/chemotaxis P33151 1003 16q21 human Y731-p 456049 PYDTLHIyGYEGSES CADH_Y-type_LIR molecular association, regulation; receptor internalization, inhibited carcinogenesis, inhibited; cell motility, inhibited; cell adhesion, inhibited; endocytosis, inhibited CTNNB1(DISRUPTS) 16027153; 33604918; 34692535 16 0 1 +FOS Fos DNA-binding; Motility/polarity/chemotaxis; Oncoprotein; Transcription factor P01100 2353 14q24.3 human K265-sm 3289000 SISSMELkTEPFDDF intracellular localization; phosphorylation transcription, inhibited 16055710 2 3 0 intranuclear distribution; phosphorylation at T232 inhibits K265 sumoylation, +BCL3 Bcl-3 Apoptosis; Nuclear receptor co-regulator; Oncoprotein; Transcription regulation P20749 602 19q13.32 human S402-p 3627521 LSASPSSsPSQSPPR protein degradation; molecular association, regulation; ubiquitination transcription, altered; cell growth, altered HDAC6(INDUCES); HDAC3(INDUCES); HDAC1(INDUCES) 15469820 1 0 0 +CTNND1 CTNND1 Actin-binding; Adaptor/scaffold; Cell adhesion; G protein regulator, misc.; Motility/polarity/chemotaxis O60716 1500 11q12.1 human S879-p 450459 LIDRNQKsDKKPDRE molecular association, regulation; intracellular localization cell motility, induced CDH5(DISRUPTS) 22798526; 26504080 7 8 0 melanoma TEM ; increases vascular permeability +H2AC11 H2A.1 DNA-binding P0C0S8 8329 6p22.1 human K15-ub 55610200 GKARAKAkTRSSRAG Histone molecular association, regulation DNA repair, induced 53BP1(INDUCES) 22980979; 29167269; 33188174 8 1 0 +ERBB2 HER2 EC 2.7.10.1; KINASE; Kinase, protein; Membrane protein, integral; Oncoprotein; Protein kinase, TK; Protein kinase, tyrosine (receptor) P04626 2064 17q12 human Y923-p 455127 MTFGAKPyDGIPARE PK_Tyr_Ser-Thr molecular association, regulation SH3BGRL3(INDUCES) 16729043 1 0 1 +Csnk1d CK1D EC 2.7.11.1; EC 2.7.11.26; KINASE; Kinase, protein; Protein kinase, CK1; Protein kinase, Ser/Thr (non-receptor) Q06486 64462 10q32.3 rat S331-p 2192627 RGLPSTAsGRLRGTQ enzymatic activity, inhibited 23861943 1 30 2 +FKBP1A FKBP12 EC 5.2.1.8; Isomerase P62942 2280 20p13 human K53-ub 7251155 PFKFMLGkQEVIRGW FKBP_C protein conformation 31375563 1 7 6 Partially unfolded but not aggregated drives FKBP12 ubiquitylation at the proteasome +Irf4 IRF4 DNA-binding; Oncoprotein; Transcription factor Q64287 16364 13|13 A3.2 mouse S446-p 26335000 YHRSLRHsSIQE___ cell differentiation, induced; transcription, induced DNA(INDUCES) 20697158 2 1 0 production of IL-17 and IL-21 +DOK1 DOK1 Adaptor/scaffold; Motility/polarity/chemotaxis Q99704 1796 2p13.1 human Y296-p 448366 LDSPPALyAEPLDSL molecular association, regulation; intracellular localization RASA1(INDUCES); CD45(INDUCES) 10688886; 19481264 4 14 166 +Klf9 KLF9 C2H2-type zinc finger protein; DNA-binding Q01713 rat S106-p 241497502 VTTESGSsPSHSPEE molecular association, regulation cell motility, inhibited JNK3(INDUCES) 28871032 1 1 0 suppress neurite growth, KLF9 S106/110A mutants enhance optic nerve axon regeneration 2 weeks after optic nerve injury +MCM3 MCM3 DNA replication; EC 3.6.4.12 P25205 4172 6p12.2 human K283-ub 58948908 FSAEDIAkIKKFSKT MCM cell cycle regulation 27621311 1 2 0 KEAP1-MCM3 associates with chromatin in a cell cycle-dependent manner +RAB3IP RAB3IP GEF; GEF, Rab Q96QF0 117177 12q15 human S165-p 472425 LSRLRSPsVLEVREK activity, induced carcinogenesis, induced; exocytosis, induced 36797475 1 5 24 +Epha4 EphA4 EC 2.7.10.1; KINASE; Kinase, protein; Membrane protein, integral; Protein kinase, TK; Protein kinase, tyrosine (receptor) Q03137 13838 1 C4|1 39.55 cM mouse Y596-p 450856 LNQGVRTyVDPFTYE EphA2_TM enzymatic activity, induced cell motility, altered; cytoskeletal reorganization 10848605; 16102535 5 14 75 YY->EE mutation induced receptor clustering that induced growth cone collapse and axonal guidance problems.; in vitro +SMAD2 SMAD2 DNA-binding; Transcription factor Q15796 4087 18q21.1 human K20-ac 478911 KRLLGWKkSAGGSGG intracellular localization cell cycle regulation; cell growth, inhibited; transcription, induced; signaling pathway regulation 17478422; 29187201 2 1 0 +HDAC5 HDAC5 DEACETYLASE; Deacetylase; EC 3.5.1.98; Hydrolase Q9UQL6 10014 17q21.31 human Y642-p 1869973801 PLQPLQVyQAPLSLA intracellular localization 32612176 1 1 0 +PARL PSARL Apoptosis; EC 3.4.21.105; Membrane protein, integral; Membrane protein, multi-pass; Mitochondrial; Protease Q9H300 55486 3q27.1 human S65-p 471330 RKVEPRRsDPGTSGE protein processing 17116872 1 1 0 involved in mitochondrial fragmentation +LBR LBR DNA-binding; Membrane protein, integral; Membrane protein, multi-pass G1N806 turkey S82-p 14575430 RSRSRSRsRSPGRPA molecular association, regulation; protein conformation H3(INDUCES) 22056509 2 4 0 +RIPK2 RIPK2 EC 2.7.10.2; EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, Ser/Thr (non-receptor); Protein kinase, TKL; Protein kinase, tyrosine (non-receptor) O43353 8767 8q21.3 human S176-p 460844 KWRMMSLsQSRSSKS PK_Tyr_Ser-Thr enzymatic activity, induced transcription, inhibited; signaling pathway regulation 16824733; 31350258 4 14 25 inhibits riposome formation +Afdn Afadin Cell adhesion; Motility/polarity/chemotaxis; Oncoprotein Q9QZQ1 17356 17|17 A1 mouse S1795-p 481813 KERQRLFsQGQDVSD phosphorylation signaling pathway regulation 34387373 2 47 300 inhibits AKT and IR phosphorylation thus regulating insulin signaling +DLGAP1 SAPAP1 iso2 Cytoskeletal O14490-2 9229 18p11.31 human S44-p 456939 CRRMRSGsYIKAMGD protein degradation; molecular association, regulation; ubiquitination neural plasticity PSD-95(DISRUPTS) 23143515 2 3 0 +IRS1 IRS1 Adaptor/scaffold; Motility/polarity/chemotaxis P35568 3667 2q36.3 human S1101-p 453434 GCRRRHSsETFSSTP protein degradation; intracellular localization; activity, inhibited 15364919; 26956053; 34253290 13 39 122 disassociation of IRS2 from plasma membrane to cytosol; limits PM-associated PI3K and PIP3 synthesis; inhibition of Pim kinases delays IRS1 degradation +Irs1 IRS1 Adaptor/scaffold; Motility/polarity/chemotaxis P35570 25467 9q34 rat S318-p 451399 MVGGKPGsFRVRASS molecular association, regulation; phosphorylation INSR(DISRUPTS) 15069075 12 17 3 Inhibits tyrosine phosphorylation +MPIG6B G6B Immunoglobulin superfamily; Membrane protein, integral; Receptor, misc. O95866 80739 6p21.33 human Y237-p 454848 PADASTIyAVVV___ G6B molecular association, regulation SH2D1B(NOT_REPORTED); CSK(INDUCES); Src(INDUCES); Syk(INDUCES); SHP-2(INDUCES); SHP-1(INDUCES); Fyn(INDUCES); PLCG2(INDUCES); Arg(NOT_REPORTED); PIK3CA(INDUCES) 23185356; 23322602 2 2 1 +TPX2 TPX2 Cell cycle regulation; Microtubule-binding Q9ULW0 22974 20q11.21 human S310-p 460756 IVKPFNLsQGKKRTF intracellular localization KPNB1(INDUCES) 29276125 1 9 23 accumulation of TPX2 at the prophase centrosome +Styk1 STYK1 EC 2.7.10.2; KINASE; Kinase, protein; Membrane protein, integral; Oncoprotein; Protein kinase, TK; Protein kinase, tyrosine (non-receptor); Protein kinase, tyrosine (receptor) Q6J9G1 243659 6|6 F3 mouse Y334-p 458344 VTLGAPPyPEVPPTS PK_Tyr_Ser-Thr apoptosis, inhibited; cell growth, altered 16322230 1 0 0 mutation of this site promotes cellular apoptosis +KDM4B JMJD2B DEMETHYLASE; Demethylase; EC 1.14.11.-; Oxidoreductase O94953 23030 19p13.3 human S352-p 4957088 TRPTALTsPELSSWS protein stabilization; ubiquitination 28945223 1 0 1 +Slc6a5 SLC6A5 Membrane protein, integral; Membrane protein, multi-pass; Transporter; Transporter, SLC family P58295 171148 1q22 rat K791-ub 31914108 LGLKLPVkDLELGTQ protein degradation; ubiquitination; intracellular localization endocytosis, induced; transcription, altered 23484054; 31628376 2 0 0 LNX2 mediated degradation was slower and seen after 48 hours, PKC regulation of SLC6A5 activity, modulation in the glycine transport activity of SLC6A5 +NFE2L2 NRF2 DNA-binding; Transcription factor Q16236 4780 2q31.2 human K541-ac 7106312 DEKEKLLkEKGENDK bZIP_Maf molecular association, regulation transcription, induced DNA(INDUCES) 19273602 1 1 0 +PKD2L1 PKD2L1 Channel, cation; Membrane protein, integral; Membrane protein, multi-pass; Motility/polarity/chemotaxis Q9P0L9 9033 10q24.31 human S682-p 394791406 EIEKLGRsIVSSPQG activity, induced 29230552 1 0 0 regulates the channel activity +LSM4 LSM4 RNA-binding; Spliceosome Q9Y4Z0 25804 19p13.11 human R125-m2 12190487 GGIPGTGrGQPEKKP molecular association, regulation SMN(INDUCES) 11720283 1 1 2 +Dusp4 DUSP4 EC 3.1.3.16; EC 3.1.3.48; PHOSPHATASE; Protein phosphatase, dual-specificity Q8BFV3 319520 8|8 A4 mouse S390-p 15412243 SNLPYLHsPITTSPS protein stabilization 22430215 2 1 2 +BCKDHB BCKDHB Amino Acid Metabolism - valine, leucine and isoleucine degradation; EC 1.2.4.4; Mitochondrial; Oxidoreductase P21953 594 6q14.1 human S318-p 3336900 DVDTICKsVIKTGRL Transketolase_C enzymatic activity, inhibited E1B-AP5(DISRUPTS) 15576032 1 0 0 +PAH PAH Amino Acid Metabolism - phenylalanine, tyrosine and tryptophan biosynthesis; EC 1.14.16.1; Oxidoreductase P00439 5053 12q23.2 human S16-p 449074 PGLGRKLsDFGQETS molecular association, regulation; protein conformation; enzymatic activity, induced PAH(DISRUPTS) 12185072; 15096628; 20937381 7 7 36 PAH G46S mutant; The conformational change is around the phosphoserine and the catalytic domain (not global). +ARHGAP24 ARHGAP24 GAP; GAP, Rac/Rho; Motility/polarity/chemotaxis Q8N264 83478 4q21.23-q21.3 human S415-p 4757012 HKLDVSRsPPLMVKK activity, induced cytoskeletal reorganization 16862148 1 13 1 membrane blebbing +SLC40A1 SLC40A1 Membrane protein, integral; Membrane protein, multi-pass; Transporter; Transporter, SLC family Q9NP59 30061 2q32.2 human Y303-p 25589101 RDGWVSYyNQPVFLA FPN1; TM receptor internalization, inhibited 22682226 1 0 0 regulates internalization partially but not hepcidin mediated internalization +LTF LTF EC 3.4.21.-; Protease; Secreted; Secreted, signal peptide P02788 4057 3p21.31 human K57-sm 41400403 GPPVSCIkRDSPIQC Transferrin transcription, inhibited 26090800 1 0 0 +FOXM1 FOXM1 iso2 DNA-binding; Transcription factor Q08050-2 2305 12p13.33 human S361-p 471396 PLLPRVSsYLVPIQF protein stabilization transcription, induced 17101782 2 0 0 plays a role in the DNA damage/checkpoint signaling +Nfatc2 NFAT1 DNA-binding; Transcription factor Q60591 18019 2 H3|2 88.91 cM mouse S223-p 447847 PRTSPIMsPRTSLAE protein stabilization; ubiquitination carcinogenesis, induced; cell growth, induced; transcription, induced; transcription, inhibited 11030334; 21628454 2 14 5 inhibits ubiquitination of NFAT1 residues K684 and K897 +KAT7 MYST2 ACETYLTRANSFERASE; Acetyltransferase; EC 2.3.1.48; Nuclear receptor co-regulator; Transcription, coactivator/corepressor O95251 11143 17q21.33 human K155-ub 1877197201 SHDESIAkDMSLKDS protein degradation 32555450 1 1 0 degraded during differentiation +IQGAP1 IQGAP1 GAP; GAP, Ras; Motility/polarity/chemotaxis P46940 8826 15q26.1 human K1465-ub 12287388 KIQTGLKkLTELGTV RasGAP_C activity, induced; molecular association, regulation cell motility, induced CDC42(INDUCES); RAC1(INDUCES) 32094223 1 6 3 K165R, K175R mutant binding compared to WT, ubiquitination of the GRD likely blocks CDC42 binding; 6KR mutant compared to WT +Nlrp3 NLRP3 Inhibitor Q8R4B8 216799 11|11 B1.3 mouse K565-ub 1881229502 VLLENYGkFEKGYLI NLRC4_HD2 activity, induced 33893171 1 0 0 inflammasome activation +Alyref2 Refbp2 DNA-binding; RNA-binding Q9JJW6 56009 1|1 H3 mouse R186-m2 13906407 GGRGSQGrGRGTGRN FoP_duplication molecular association, regulation RNA(DISRUPTS) 20129943 1 1 0 +Pfkfb3 PFKFB3 Carbohydrate Metabolism - fructose and mannose; EC 2.7.1.105; EC 3.1.3.46; KINASE; Kinase, other; Motility/polarity/chemotaxis; PHOSPHATASE; Phosphatase (non-protein) Q9ESY2 170768 2|2 A1 mouse S478-p 9318263 TKKPRINsFEERVAS protein stabilization; ubiquitination; enzymatic activity, induced carcinogenesis, induced; cell motility, induced; cell growth, induced 33931981 2 6 5 promotes glycolysis and Paclitaxel resistance; inhibits ubiquitination +SREBF1 SREBP-1 DNA-binding; Membrane protein, integral; Membrane protein, multi-pass; Transcription factor P36956 6720 17p11.2 human K123-sm 2715401 FSPGPGIkEESVPLS transcription, inhibited 12615929 3 1 0 +Slc10a1 NTCP Membrane protein, integral; Membrane protein, multi-pass; Transporter P26435 24777 6q24 rat S226-p 456205 TPHLLATsSLMPFSG intracellular localization endocytosis, induced 16027164; 24008362 2 0 0 PMA induced internalization of NTCP +FOXO4 FOXO4 DNA-binding; Oncoprotein; Transcription factor P98177 4303 Xq13.1 human K186-ac 459042 MLNPEGGkSGKAPRR Forkhead activity, inhibited transcription, inhibited 12964026 2 0 0 +PLXNB1 PLXNB1 Membrane protein, integral; Motility/polarity/chemotaxis; Receptor, misc. O43157 5364 3p21.31 human Y1732-p 11485312 SVTGKAKyTLNDNRL Plexin_cytopl molecular association, regulation cell motility, altered GRB2(INDUCES); PLCG1(INDUCES); PLCG2(INDUCES) 19805522 1 0 0 +Cfl1 Cofilin-1 Cytoskeletal; Motility/polarity/chemotaxis; Nuclear receptor co-regulator P18760 12631 19|19 A mouse T25-p 7990494 MKVRKSStPEEVKKR Cofilin_ADF activity, induced; protein stabilization; ubiquitination; intracellular localization cytoskeletal reorganization 29878125; 34433058 2 19 15 cofilin-1 phosphorylated on T25 can impair skeletal muscle conrtraction by modulating sarcomeric actin dynamics.; Alters sarcomeric organization inducing cardiac dysfunction +FES Fes EC 2.7.10.2; KINASE; Kinase, protein; Oncoprotein; Protein kinase, TK; Protein kinase, tyrosine (non-receptor); Tumor suppressor P07332 2242 15q26.1 human Y713-p 448353 REEADGVyAASGGLR PK_Tyr_Ser-Thr molecular association, regulation; enzymatic activity, induced cell differentiation, altered; cell growth, altered Fes(INDUCES); Src(NOT_REPORTED) 18046454; 18775312; 7687763; 8334128; 8663427 6 8 114 Y713F mutant was associated with a reduction in levels of Bcr.; mutation of this site reduces autophosphorylation of Y811 +Fxyd1 PLM Cell surface; Channel, misc.; Membrane protein, integral Q9Z239 56188 7|7 B1 mouse S89-p 455220 SSIRRLSsRRR____ intracellular localization 16371442 8 1 49 After stimulation with phorbol ester. +TP73 p73 iso2 DNA-binding; Transcription factor; Tumor suppressor O15350-2 7161 1p36.32 human S289-p 455781 GQVLGRRsFEGRICA P53 activity, induced apoptosis, induced; transcription, altered 12097319 1 0 0 +PLD2 PLD2 EC 3.1.4.4; Lipid Metabolism - ether lipid; Lipid Metabolism - glycerophospholipid; Motility/polarity/chemotaxis; Phospholipase O14939 5338 17p13.2 human Y296-p 10036102 LILKCSSyRQARWWA enzymatic activity, inhibited; enzymatic activity, induced carcinogenesis, inhibited; cell motility, altered 19715678; 20176813; 20647543 3 1 0 +MAP3K11 MLK3 EC 2.7.11.25; KINASE; Kinase, protein; Protein kinase, Ser/Thr (non-receptor); Protein kinase, TKL Q16584 4296 11q13.1 human S705-p 448610 FSLKTPDsPPTPAPL molecular association, regulation BRAF(DISRUPTS) 29084209 2 6 0 oxidative stress-induced invasion of colon cancer cells; promotes MLK3-dependent B-Raf and ERK1/2 activation +CRABP2 CRABP2 Nuclear receptor co-regulator P29373 1382 1q23.1 human K102-sm 25171020 VCEQKLLkGEGPKTS Lipocalin intracellular localization transcription, induced 21998312 1 0 0 translocates from ER to the nucleus +NFE2L2 NRF2 DNA-binding; Transcription factor Q16236 4780 2q31.2 human K110-sm 1877458700 SQVAHIPkSDALYFD intracellular localization carcinogenesis, induced; cell growth, induced; cell motility, inhibited; transcription, induced; cell adhesion, inhibited 31546024; 33299528 2 1 0 increased the antioxidant ability of NRF2 and reduced cellular ROS levels; binding to the GPX2 promoter, recruitment of the coactivator CHD-6, decreases intracellular ROS level in hepatocellular carcinoma (HCC), upregulates PHGDH expression, serine accumulation, resistance to serine starvation, SUMOylation maintains HCC tumorigenesis +BUB1B BUB1B EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, Other; Protein kinase, Ser/Thr (non-receptor); Tumor suppressor O60566 701 15q15.1 human S1043-p 483373 WKVGKLTsPGALLFQ cell cycle regulation 19015317 3 9 3 pS1043 Ab delayed anaphase onset in vivo and in vitro +EEF2K EEF2K EC 2.7.11.20; KINASE; Kinase, protein; Protein kinase, Ser/Thr (non-receptor); Protein kinase, atypical; Translation O00418 29904 16p12.2 human S441-p 23101751 ESENSGDsGYPSEKR protein degradation; molecular association, regulation; ubiquitination translation, induced BTRC(INDUCES); BRD8(INDUCES) 22669845; 25670349 2 3 1 +Cux1 CUTL1 DNA-binding; Membrane protein, integral; Transcription factor P53564 13047 5 G2|5 75.96 cM mouse S1232-p 456479 IDYSQGAsPQPQHQL molecular association, regulation DNA(DISRUPTS) 16081423 2 8 4 +USP8 USP8 DEUBIQUITINASE; EC 3.4.19.12; Protease; Ubiquitin conjugating system; Ubiquitin-specific protease P40818 9101 15q21.2 human Y717-p 484371 PSKLKRSySSPDITQ cell cycle regulation 29472535 1 2 4 trichoplein-mediated inhibition of ciliogenesis +RRN3 TIF1A Nucleolus; Transcription initiation complex Q9NYV6 54700 16p13.11 human S199-p 470003 IIARYVPsTPWFLMP RRN3 molecular association, regulation; activity, inhibited transcription, altered eIF3S6IP(DISRUPTS); TAF4(DISRUPTS) 15004009 2 0 0 +Frs2 FRS2 Adaptor/scaffold Q8C180 327826 10|10 D2 mouse Y349-p 449784 RRPALLNyENLPSLP molecular association, regulation GRB2(INDUCES) 9182757 3 11 89 +EEF2K EEF2K EC 2.7.11.20; KINASE; Kinase, protein; Protein kinase, Ser/Thr (non-receptor); Protein kinase, atypical; Translation O00418 29904 16p12.2 human S500-p 455998 RLHLPRAsAVALEVQ molecular association, regulation; protein conformation; enzymatic activity, induced Calmodulin(INDUCES) 27956550 6 9 2 +PTPN18 BDP1 EC 3.1.3.48; Motility/polarity/chemotaxis; PHOSPHATASE; Protein phosphatase, tyrosine (non-receptor) Q99952 26469 2q21.1 human Y281-p 450259 AVQTEEQyRFLYHTV Y_phosphatase molecular association, regulation TEC(INDUCES) 14679216 1 0 0 +AKT1 Akt1 EC 2.7.11.1; KINASE; Kinase, protein; Oncoprotein; Protein kinase, AGC; Protein kinase, Ser/Thr (non-receptor) Q01314 280991 cow T308-p 447856 KDGATMKtFCGTPEY Pkinase intracellular localization; enzymatic activity, induced 12167717 802 14 18 Translocation to the plasma membrane leads to phosphorylation. +Map1s BPY2-IP1 Apoptosis; Microtubule-binding Q8C052 270058 8|8 B3.3 mouse S786-p 27444827 KAPARPSsASATPRA cytoskeletal reorganization 30266824 1 6 1 inhibit microtubule binding +Rims1 RIMS1 Adaptor/scaffold; Vesicle Q9JIR4 84556 9q13 rat S991-p 481204 PNVPLQRsLDEIHPT neural plasticity 35443170 1 13 1 +Cdh2 CDH2 Cell adhesion; Membrane protein, integral; Motility/polarity/chemotaxis Q9Z1Y3 83501 18p13 rat S869-p 382737701 GSGSTAGsLSSLNSS CADH_Y-type_LIR intracellular localization cytoskeletal reorganization CTNNB1(INDUCES) 29133434 1 0 0 PKD1 colocalizes with N-cadherin at dendritic spines mainly in the postsynaptic compartment, long-term potentiation (LTP) induction and regulates synaptic plasticity +PTK2 FAK EC 2.7.10.2; KINASE; Kinase, protein; Protein kinase, TK; Protein kinase, tyrosine (non-receptor) Q05397 5747 8q24.3 human K152-sm 2793927 NFFYQQVkSDYMLEI FERM_M activity, induced; phosphorylation 34619327 2 0 0 FAK K152 sumoylation is associated with increased FAK Y397 phosphorylation; NFkB activation, ICAM-1, TNF-alpha, and p53 expression endothelial cell activation, inflammation and senescence +HAUS8 HAUS8 Cell cycle regulation Q9BT25 93323 19p13.11 human S20-p 20583301 ATGPTNSsSAKKKDK molecular association, regulation; intracellular localization cell cycle regulation; cytoskeletal reorganization 21705324 2 1 0 disrupts microtubule binding +XBP1 XBP1 DNA-binding; Transcription factor P17861 7494 22q12.1|22q12 human S68-p 21688102 RQRLTHLsPEEKALR bZIP_2 protein degradation; molecular association, regulation; intracellular localization FOXO1A(INDUCES) 23277279 4 7 0 +NGEF ephexin-1 GEF; GEF, Rac/Rho Q8N5V2 25791 2q37.1 human S16-p 34501054 LEKTRRKsASDQWNT molecular association, regulation; phosphorylation carcinogenesis, induced; cell growth, induced; signaling pathway regulation KRas(INDUCES) 34711817 1 2 0 induces C-Raf phosphorylation, induces Ras/MAPK signaling pathway +Arhgef16 ARHGEF16 GEF; GEF, Rac/Rho; Motility/polarity/chemotaxis Q3U5C8 230972 4|4 E2 mouse Y220-p 2424921 FKDDPQLyQEIRERG activity, induced; protein conformation cell motility, induced 33597305 1 4 35 +Ptprb PTPRB EC 3.1.3.48; Membrane protein, integral; Motility/polarity/chemotaxis; PHOSPHATASE; Receptor protein phosphatase, tyrosine B2RU80 19263 10|10 D2 mouse Y1982-p 454267 ENPLFPIyENVNPEY molecular association, regulation cytoskeletal reorganization GRB2(INDUCES); Fyn(INDUCES) 20398064 2 1 39 +OGG1 OGG1 DNA repair, damage; Deoxyribonuclease; EC 4.2.99.18; Lyase O15527 4968 3p25.3 human S232-p 10036104 LQQLRESsYEEAHKA HhH-GPD enzymatic activity, inhibited 19674107 1 0 0 +MCC MCC Cell cycle regulation; Tumor suppressor P23508 4163 5q22.2 human S118-p 3624820 SELRSELsQSQHEVN activity, induced cell cycle regulation 21779472 1 7 2 +CTTN Cortactin Actin-binding; Cytoskeletal; Motility/polarity/chemotaxis Q14247 2017 11q13.3 human S261-p 13879503 EKLQLHEsQKDYKTG HS1_rep molecular association, regulation DYN2(INDUCES) 24753582 1 18 4 formation of matrix, endosomal accumulation of cortactin and its association with DYN2, endosome dynamics during the invasive program of breast tumor cells +DDX60 DDX60 EC 3.6.4.13; Hydrolase Q8IY21 55601 4q32.3 human Y796-p 2183532 SGKTYASyYCMEKVL DEAD molecular association, regulation transcription, inhibited 25981042 1 1 0 reduced ATP binding, inhibited RIG-I-mediated IFN-beta promoter activation +EDC4 EDC4 RNA processing Q6P2E9 23644 16q22.1 human S855-p 56660920 GLQEKHKsLAFHRPP RNA stability, altered 30467221 1 2 0 increase formation of P bodies +Zfpm2 FOG2 C2H2-type zinc finger protein; Nuclear receptor co-regulator Q8CCH7 22762 15 B3.1|15 15.74 cM mouse K324-sm 1873213005 LNSHSGVkMEEFLPP molecular association, regulation transcription, induced GATA4(DISRUPTS) 23226341 1 0 0 desumoylation induces repression +EIF2AK3 PERK EC 2.7.11.1; KINASE; Kinase, protein; Membrane protein, integral; Protein kinase, Other; Protein kinase, Ser/Thr (non-receptor); Translation Q9NZJ5 9451 2p11.2 human S715-p 4270777 HIEIIAPsPQRSRSF phosphorylation transcription, induced 30045994 2 21 1 induces phosphorylation of ELF2a +LYN LYN EC 2.7.10.2; KINASE; Kinase, protein; Oncoprotein; Protein kinase, TK; Protein kinase, tyrosine (non-receptor) P07948 4067 8q12.1 human Y397-p 448695 RVIEDNEyTAREGAK PK_Tyr_Ser-Thr molecular association, regulation; enzymatic activity, induced DNA repair, induced; carcinogenesis, induced; cell motility, induced; cell growth, induced; apoptosis, inhibited; signaling pathway regulation; cell growth, altered STAT3(INDUCES); PAG(INDUCES) 15626731; 18070987; 20564182; 29050963; 29989005; 33512474 34 61 2054 induces cytokine signaling +LRP2 LRP2 Membrane protein, integral; Motility/polarity/chemotaxis; Receptor, misc. P98164 4036 2q31.1 human S4527-p 767902 IFENPMYsARDSAVK receptor internalization, altered; receptor recycling, altered 17555532 1 0 0 +CDKN1B p27Kip1 Cell cycle regulation; Inhibitor; Oncoprotein; Protein kinase, regulatory subunit P46527 1027 12p13.1 human K134-ub 5018202 DTHLVDPkTDPSDSQ protein degradation cell cycle regulation 10318797; 19056892 2 0 0 +MYH10 MYH10 Motility/polarity/chemotaxis; Motor P35580 4628 17p13.1 human S1937-p 2017900 RGGPISFsSSRSGRR molecular association, regulation; intracellular localization; activity, inhibited cytoskeletal reorganization MYH10(INDUCES); ACTA1(INDUCES) 16611744; 25869664; 30655296 3 19 2 +ETS1 Ets-1 DNA-binding; Motility/polarity/chemotaxis; Oncoprotein; Transcription factor P13474 396235 chicken S251-p 449316 GKLGGQDsFESIESY Ets1_N_flank activity, inhibited 7961750 4 13 1 The in vitro interaction of Ets-1 with a high-affinity Ets binding site was assayed with EMSA. +H4C1 H4 DNA-binding P62805 8359 6p22.2 human R3-m2 477687 _____SGrGKGGKGL protein stabilization; molecular association, regulation; acetylation cell growth, induced; chromatin organization, altered; cell differentiation, induced; apoptosis, inhibited; transcription, induced PCAF(INDUCES); PSME4(DISRUPTS) 16103216; 20068219; 32447347; 33989303 10 2 0 +ESPL1 separase EC 3.4.22.49; Protease Q14674 9700 12q13.13 human S1126-p 447673 IAPSTNSsPVLKTKP molecular association, regulation; enzymatic activity, inhibited; protein conformation cell cycle regulation CCNB1(INDUCES); PIN1(INDUCES) 11747808; 16868023; 17974570; 21743463; 25921067 11 10 0 separation of sister chromatids and centriole engagement +ADRB1 ADRB1 GPCR, family 1; Membrane protein, integral; Membrane protein, multi-pass; Receptor, GPCR P08588 153 10q25.3 human S475-p 31010700 RPGFASEsKV_____ receptor recycling, inhibited 24324269 1 0 0 +SASH1 SASH1 Tumor suppressor O94885 23328 6q24.3-q25.1 human S407-p 468680 LSHGRTCsFGGFDLT SLY cytoskeletal reorganization; cell motility, inhibited; signaling pathway regulation 32523092 1 38 12 Hippo/YAP signaling +OPRM1 MOR-1 GPCR, family 1; Membrane protein, integral; Membrane protein, multi-pass; Receptor, GPCR P35372 4988 6q25.2 human S365-p 447783 SNIEQQNsTRIRQNT receptor internalization, altered 18463167 11 6 0 +DMTN dematin Actin-binding; Motility/polarity/chemotaxis; Tumor suppressor Q08495 2039 8p21.3 human S403-p 450255 NELKKKAsLF_____ VHP protein conformation 16472756 5 0 0 controls the actin bundling activity of dematin +SORL1 SORL1 Cell surface; Membrane protein, integral; Receptor, misc. Q92673 6653 11q24.1 human S2206-p 11546400 APMITGFsDDVPMVI molecular association, regulation; protein processing GGA1(INDUCES) 20015111; 21147781 2 1 0 necessary for SORL1 ectodomain shedding +SNCA SNCA Adaptor/scaffold P37840 6622 4q22.1 human T72-gl 10338200 NVGGAVVtGVTAVAQ Synuclein protein stabilization 30651314 1 4 0 inhibits the aggregation of alpha-synuclein but can also alter the structure of a-synuclein aggregates in site specific ways, inhibit a-Synuclein toxicity +TFEB TFEB DNA-binding; Transcription factor P19484 7942 6p21.1 human S138-p 3181625 LSSSAGNsAPNSPMA MITF_TFEB_C_3_N intracellular localization 33753903 1 11 0 +Ulk1 ULK1 Autophagy; EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, Other; Protein kinase, Ser/Thr (non-receptor) NP_001101811 360827 12q16 rat S555-p 3176155 GLGCRLHsAPNLSDF autophagy, induced 37009319 61 26 48 +Snapin SNAPIN Vesicle Q9Z266 20615 3|3 F1 mouse S50-p 448453 HVHAVREsQVELREQ Snapin_Pallidin molecular association, regulation cell growth, inhibited; cell motility, inhibited SNAP-25(INDUCES); DNCLI1(DISRUPTS) 21986494; 26108535 5 0 0 +UBXN2B UBXN2B Adaptor/scaffold; Endoplasmic reticulum Q14CS0 137886 8q12.1 human T59-p 3217944 TVFKSPRtPPQRFYS molecular association, regulation; intracellular localization 20875789 1 9 6 important for Golgi disassembly at mitosis; inhibits p37 binding to Golgi membranes +ARHGEF2 ARHGEF2 GEF; GEF, Rac/Rho; Motility/polarity/chemotaxis Q92974 9181 1q22 human T679-p 449343 PGVELLLtPREPALP activity, induced; molecular association, regulation cytoskeletal reorganization RHOA(INDUCES) 18211802; 19261619 4 10 29 activates RhoA and as a result regulates actin assembly +Dlg4 PSD-95 Adaptor/scaffold P31016 29495 10q24 rat Y533-p 473111 VTQMEVHyARPIIIL Guanylate_kin molecular association, regulation; intracellular localization 20220006 1 0 2 regulates synaptic clustering +AP4E1 AP4E1 Adaptor/scaffold Q9UPM8 23431 15q21.2 human S868-p 22598801 LPLVEKFsYCSLSTP receptor recycling, inhibited 21810154 1 0 0 +NOS3 eNOS Amino Acid Metabolism - arginine and proline; EC 1.14.13.39; Oxidoreductase P29473 287024 cow Y83-p 456466 WELGSITyDTLCAQS enzymatic activity, induced 16123043; 18096817; 23727078 5 2 0 +Smo SMO Cell development/differentiation; GPCR, Fz/Smo family; Membrane protein, integral; Membrane protein, multi-pass; Oncoprotein; Receptor, GPCR P56726 319757 6 A3.3|6 12.36 cM mouse S594-p 1872776114 PGQELSFsMHTVSHD molecular association, regulation transcription, induced PKACA(INDUCES) 33886552 1 1 0 +Akt2 Akt2 EC 2.7.11.1; KINASE; Kinase, protein; Oncoprotein; Protein kinase, AGC; Protein kinase, Ser/Thr (non-receptor) P47197 25233 1q21 rat T309-p 448537 SDGATMKtFCGTPEY Pkinase activity, induced 22846604 16 5 23 Glucose uptake in skeletal muscles +PHLPP1 PHLPP EC 3.1.3.16; PHOSPHATASE; Protein phosphatase, Ser/Thr (non-receptor); Tumor suppressor O60346 23239 18q21.33 human S317-p 25172982 GGWSRRAsPAPSDSS cell cycle regulation 33397691 1 8 0 +P2RY1 P2RY1 GPCR, family 1; Membrane protein, integral; Membrane protein, multi-pass; Receptor, GPCR P47900 5028 3q25.2 human T358-p 10897605 QSKSEDMtLNILPEF receptor internalization, altered 19741005 1 0 0 important for beta-arrestin 2 translocation to the plasma membrane +PAK2 PAK2 EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, STE; Protein kinase, Ser/Thr (non-receptor) Q29502 100009535 rabbit S141-p 448295 TVKQKYLsFTPPEKD enzymatic activity, induced CDC42 iso1(DISRUPTS) 16204230; 18984590 17 84 76 +NPM1 NPM1 Nucleolus; Oncoprotein; RNA-binding; Translation P06748 4869 5q35.1 human K267-ac 461149 SLPKVEAkFINYVKN NPM1-C molecular association, regulation; intracellular localization transcription, altered H3(INDUCES) 19581289 1 10 136 K212/215/229/230/257/267/292R mutant +H3C14 HIST2H3A/C/D DNA-binding Q71DI3 126961 1q21.2 human K79-m1 18465116 REIAQDFkTDLRFQS Histone molecular association, regulation L3MBTL iso4(INDUCES) 23583077 0 5 15 +CRTC1 TORC1 iso2 Transcription factor Q6UUV9-2 23373 19p13.11 human S155-p 8110001 PYGTMYLsPPADTSW protein degradation transcription, inhibited 29408765 1 3 10 +MAPK14 P38A EC 2.7.11.24; KINASE; Kinase, protein; Protein kinase, CMGC; Protein kinase, Ser/Thr (non-receptor) Q16539 1432 6p21.31 human K165-me 1884812100 VNEDCELkILDFGLA protein stabilization; enzymatic activity, induced 35992062 1 1 0 +TBC1D4 AS160 GAP; GAP, Rab O60343 9882 13q22.2 human S341-p 455922 QPRRRHAsAPSHVQP PID molecular association, regulation 14-3-3 beta(INDUCES); 14-3-3 epsilon(INDUCES) 17617058; 20410134 9 57 335 multiple sites (6P) mutant +PRKDC DNAPK DNA repair, damage; EC 2.7.11.1; KINASE; Kinase, protein; Nucleolus; Protein kinase, Ser/Thr (non-receptor); Protein kinase, atypical P78527 5591 8q11.21 human S2655-p 23099448 QTADGRSsFDWLTGS DNAPKcs_CC5 DNA repair, inhibited 24687855 1 1 1 cell survival inhibited +Rela NFkB-p65 DNA-binding; Nuclear receptor co-regulator; Transcription factor Q04207 19697 19 A|19 4.34 cM mouse K123-ac 458971 LGIQCVKkRDLEQAI RHD_DNA_bind intracellular localization; phosphorylation cell differentiation, induced; transcription, inhibited; transcription, altered; signaling pathway regulation 26391411; 27381458 4 0 0 +Smad1 SMAD1 DNA-binding; Transcription factor P97588 25671 19q11 rat S468-p 448363 HNPISSVs_______ cell growth, induced; signaling pathway regulation 21445358 12 20 59 Src/SMAD1 signaling pathway +Stip1 STI1 Chaperone Q60864 20867 19|19 A mouse T198-p 465576 DEEEEAAtPPPPPPP intracellular localization 14754904 2 2 2 +PDE10A PDE10A iso2 EC 3.1.4.17; EC 3.1.4.35; Nucleotide Metabolism - purine; Phosphodiesterase Q9Y233-2 10846 6q27 human T16-p 478273 ASCFRRLtECFLSPS intracellular localization; palmitoylation 14604994; 20610737 2 0 0 +NSFL1C NSFL1C Vesicle Q9UNZ2 55968 20p13 human S140-p 455619 AVERVTKsPGETSKP intracellular localization cytoskeletal reorganization 12810701 1 32 4 +Hcls1 HS1 Adaptor/scaffold; Motility/polarity/chemotaxis P49710 15163 16|16 B3 mouse Y388-p 451635 EPETEPDyEDVGELD molecular association, regulation; intracellular localization ITK(INDUCES) 15166239; 19917685 8 2 37 +PTPN7 HePTP EC 3.1.3.48; Motility/polarity/chemotaxis; PHOSPHATASE; Protein phosphatase, tyrosine (non-receptor) P35236 5778 1q32.1 human T66-p 448311 EPICSVNtPREVTLH molecular association, regulation; protein conformation ERK2(DISRUPTS); P38A(DISRUPTS) 10206983; 16226275 3 5 52 +RPTOR Raptor Adaptor/scaffold Q8N122 57521 17q25.3 human S606-p 53407301 SAHEKLYsLLSDPIP HEAT molecular association, regulation; phosphorylation carcinogenesis, inhibited; cell growth, inhibited; transcription, inhibited; signaling pathway regulation RHEB(DISRUPTS); DEPTOR(INDUCES) 32015438 1 1 0 inhibits phosphorylation of S6K1, inhibits mTORC1 signaling +Oprk1 KOR-1 GPCR, family 1; Membrane protein, integral; Membrane protein, multi-pass; Receptor, GPCR P34975 29335 5q12 rat Y87-p 3082310 VMFVIIRyTKMKTAT 7tm_1 activity, induced 10995763 1 0 0 potentiation for KIR3 activation +TNNI3 TNNI3 Actin-binding; Motility/polarity/chemotaxis; Motor P19429 7137 19q13.42 human T31-p 6796401 SNYRAYAtEPHAKKK Troponin-I_N molecular association, regulation; protein conformation C16orf82(INDUCES); TNC(INDUCES) 18986304 1 0 0 +SNAI2 Snail2 Apoptosis; C2H2-type zinc finger protein; Motility/polarity/chemotaxis; Transcription factor O43623 6591 8q11.21 human S104-p 25603909 KDHSGSEsPISDEEE protein degradation; ubiquitination cell cycle regulation; transcription, induced; cell motility, inhibited CHIP(INDUCES) 23851495; 24662826 4 3 0 +TXNIP TXNIP Apoptosis; Mitochondrial; Motility/polarity/chemotaxis; Tumor suppressor Q9H3M7 10628 1q21.1 human T349-p 3212307 HRLESPTtPLLDDMD protein degradation; ubiquitination 31320475 1 5 8 +TFEB TFEB DNA-binding; Transcription factor P19484 7942 6p21.1 human K279-ac 1878278900 WNKGTILkASVDYIR molecular association, regulation autophagy, inhibited; transcription, inhibited TFEB(DISRUPTS) DNA(DISRUPTS) 31750630 1 0 0 suppresses TFEB transcriptional activity, knocking down dGcn5 in Drosophila eyes reduced hTau aggregation +EEF2K EEF2K EC 2.7.11.20; KINASE; Kinase, protein; Protein kinase, Ser/Thr (non-receptor); Protein kinase, atypical; Translation O00418 29904 16p12.2 human K603-ub 12106679 KGFDYLLkAAEAGDR ubiquitination 25670349 1 5 14 +PTH1R PTHR GPCR, family 2; Membrane protein, integral; Membrane protein, multi-pass; Receptor, GPCR Q03431 5745 3p21.31 human K388-ub 919371600 IVRVLATkLRETNAG 7tm_2 ubiquitination 29444827 1 1 0 abrogation of phosphorylation at positions T387and T392 dramatically decreased PTHR ubiquitination +Bmal1 BMAL1 iso4 DNA-binding; Transcription factor Q9WTL8-4 11865 7 F1|7 59.17 cM mouse S42-p 25230400 CNRKRKGsATDYQES activity, induced transcription, altered 31150620 4 3 2 transcriptional oscillation, synchronization of circadian clocks in peripheral tissues +NFS1 NFS1 Cofactor and Vitamin Metabolism - thiamine; EC 2.8.1.7; Mitochondrial; Transferase Q9Y697 9054 20q11.22 human S293-p 1876620104 GQERGMRsGTVPTPL Aminotran_5 carcinogenesis, induced; apoptosis, inhibited 35221331 1 0 0 +GATA2 GATA2 Transcription factor P23769 2624 3q21.3 human K424-ub 1883354003 LSKCMQEkSSPFSAA cell growth, inhibited 36251994 1 0 0 +TTK TTK Cancer Testis Antigen (CTA); EC 2.7.12.1; KINASE; Kinase, protein; Protein kinase, Other; Protein kinase, dual-specificity (non-receptor) P33981 7272 6q14.1 human S49-p 1880463704 SADTTDNsGTVNQIM intracellular localization 36395767 1 0 0 +Alyref2 Refbp2 DNA-binding; RNA-binding Q9JJW6 56009 1|1 H3 mouse R37-m1 13906416 RNRPAIArGGRNRPA molecular association, regulation RNA(DISRUPTS) 20129943 1 1 0 +Ep300 p300 ACETYLTRANSFERASE; Acetyltransferase; EC 2.3.1.48; Motility/polarity/chemotaxis; Nuclear receptor co-regulator; Transcription, coactivator/corepressor B2RWS6 328572 15|15 E1 mouse S1733-p 1295500 PGDSRRLsIQRCIQS molecular association, regulation cell differentiation, induced MyoD(INDUCES) 17964260 1 0 0 Muscle differentiation +Myb Myb DNA-binding; Oncoprotein; Transcription factor P06876 17863 10 A3|10 9.75 cM mouse T486-p 1308921 PLKMLPQtPSHAVED Cmyb_C sumoylation; protein degradation apoptosis, inhibited; transcription, induced 18006338; 24257756 2 1 0 inhibits Myb sumoylation; stress-induced degredation +BMAL1 BMAL1 DNA-binding; Transcription factor O00327 406 11p15.3 human K538-ac 1968606 DASSPGGkKILNGGT molecular association, regulation transcription, inhibited; transcription, altered CRY1(INDUCES) 18419267; 28388406 8 0 0 +Smad2 SMAD2 DNA-binding; Transcription factor Q62432 17126 18 E3|18 51.42 cM mouse T324-p 23146436 SNVNRNAtVEMTRRH MH2 activity, inhibited cell differentiation, inhibited 28400474 1 0 1 +CGGBP1 CGGBP1 Transcription regulation Q9UFW8 8545 3p11.1 human S164-p 482269 NENQLLNsQDC____ cell cycle regulation; cell growth, induced; DNA repair, inhibited 24196442 1 8 4 telomere integrity, enhances POT1 binding to DNA +SPHK2 SPHK2 EC 2.7.1.91; Kinase, lipid; Lipid Metabolism - sphingolipid Q9NRA0 56848 19q13.33 human S419-p 486446 AHSPLHRsVSDLPLP intracellular localization 17635916 1 0 0 regulation of nuclear shuttling +FANCM FANCM EC 3.6.4.13; Helicase Q8IYD8 57697 14q21.2 human S1045-p 28117600 LSHSAVNsQQNLELN molecular association, regulation; intracellular localization cell cycle regulation; DNA repair, altered; signaling pathway regulation MCM2(INDUCES) 23698467; 31067464 2 1 0 FANCM is recruited to DNA replication fork. +C5AR1 C5aR GPCR, family 1; Membrane protein, integral; Membrane protein, multi-pass; Receptor, GPCR P21730 728 19q13.32 human S334-p 448819 SVVRESKsFTRSTVD molecular association, regulation; receptor desensitization, altered ARRB1(INDUCES); ARRB2(INDUCES) 10636859; 12464600; 17145764 4 0 2 induces translocation of beta-arrestin to the plasma membrane +MVB12B FAM125B Vesicle Q9H7P6 89853 9q33.3 human Y243-p 15167001 STRTDYEyQHSNLYA DUF2464 protein degradation; ubiquitination 20654576 1 1 2 +HSF4 HSF4 Cell development/differentiation; DNA-binding; Transcription, coactivator/corepressor Q9ULV5 3299 16q22.1 human S298-p 4037600 LLKEEPAsPGGDGEA sumoylation; protein stabilization; molecular association, regulation; activity, inhibited transcription, inhibited DAXX(INDUCES) 16371476; 20620219; 30316871 3 1 0 +Dvl1 DVL1 Inhibitor P51141 13542 4 E2|4 87.61 cM mouse S139-p 470073 DNETGTEsMVSHRRE Dishevelled activity, induced cell differentiation, altered 16965538 1 0 0 contributes to B-catenin-dependent Wnt signaling; mutation of this site inhibits double axis formation in Xenopus embryos +BECN1 beclin 1 Adaptor/scaffold; Autophagy; Membrane protein, peripheral Q14457 8678 17q21.31 human T119-p 6406000 LSRRLKVtGDLFDIM BH3 activity, induced; molecular association, regulation Bcl-2(DISRUPTS); Bcl-xL(DISRUPTS) 19180116; 19395874 4 0 0 +SP3 SP3 C2H2-type zinc finger protein; DNA-binding Q02447 6670 2q31.1 human K551-ac 459093 SPADIRIkEEEPDPE transcription, induced 15554904 3 0 0 +Slc12a5 KCC2 iso2 Membrane protein, integral; Membrane protein, multi-pass; Transporter; Transporter, SLC family Q91V14-2 57138 2|2 H3 mouse T1008-p 4767307 PEVHLTWtKDKSVAE SLC12 activity, inhibited 27025876; 30201606 3 1 0 transport activity decreased +Tbx21 TBX21 DNA-binding; Transcription factor Q9JKD8 57765 11|11 D mouse S52-p 64227002 TDRRAGSsLGTPYSG transcription, induced 28424242 1 1 0 induce IFN-gamma expression +Map2k1 MEK1 EC 2.7.12.2; KINASE; Kinase, protein; Protein kinase, STE; Protein kinase, dual-specificity (non-receptor) P31938 26395 9 C|9 34.55 cM mouse T286-p 448286 VEGDAAEtPPRPRTP Pkinase enzymatic activity, inhibited 11684694 8 6 16 +CEP131 CEP131 Calcium-binding Q9UPN4 22994 17q25.3 human S47-p 3216078 KPIVRSVsVVTGSEQ molecular association, regulation 14-3-3 zeta(INDUCES); 14-3-3 epsilon(INDUCES) 26616734 1 21 8 14-3-3-dependent centriolar satellite remodelling upon cell stress. +ACE2 ACE2 EC 3.4.17.23; Membrane protein, integral; Protease Q9BYF1 59272 Xp22.2 human R671-m2 1883574201 LFGEEDVrVANLKPR Collectrin molecular association, regulation Spike Glycoprotein(INDUCES) 36114164 1 1 0 GSK3326595 inhibits SARS-CoV-2 spike pseudovirus infection host cells; GSK3326595 strongly inhibits ACE2-RBD interaction, also inhibits SARS-CoV-2 Omicron Spike1 protein +Ahrr AHRR Transcription factor Q3U1U7 11624 13|13 C1 mouse K583-sm 6423503 FPARMHLkTEPDYRQ molecular association, regulation transcription, inhibited ANKRA2(INDUCES); HDAC5(INDUCES); HDAC4(INDUCES) 19251700 1 2 0 +PKP1 plakophilin 1 Cell adhesion; Motility/polarity/chemotaxis Q13835 5317 1q32.1 human T189-p 15413424 NRYSFYStCSGQKAI activity, induced; protein stabilization cell motility, induced; cell growth, induced; translation, induced; cell adhesion, inhibited 23444369 1 1 9 +LTC4S LTC4S EC 4.4.1.20; Endoplasmic reticulum; Lipid Metabolism - arachidonic acid; Lyase; Membrane protein, integral; Membrane protein, multi-pass; Nuclear envelope Q16873 4056 5q35.3 human S36-p 40511991 ARRAFRVsPPLTTGP MAPEG enzymatic activity, inhibited; protein conformation 27365393 1 2 0 +SP1 SP1 C2H2-type zinc finger protein; DNA-binding; Transcription factor P08047 6667 12q13.13 human K16-sm 2535901 DEMTAVVkIEKGVGG protein degradation; molecular association, regulation; ubiquitination; intracellular localization DNA repair, induced; transcription, inhibited RPT6(INDUCES); RNF4(INDUCES) 18572193; 35124373 3 2 0 +PQBP1 PQBP1 Transcription, coactivator/corepressor O60828 10084 Xp11.23 human S247-p 3175780 FQQRPYPsPGAVLRA molecular association, regulation transcription, induced cGAS(INDUCES) 34385679 1 14 6 binding to cGAS induces cGAS oligomerization +KCNQ5 Kv7.5 Channel, potassium; Membrane protein, integral; Membrane protein, multi-pass Q9NR82 56479 6q13 human S88-p 4780184 GKQGARMsLLGKPLS activity, induced 30061510 1 2 0 +DUSP16 DUSP16 EC 3.1.3.16; EC 3.1.3.48; PHOSPHATASE; Protein phosphatase, dual-specificity Q9BY84 80824 12p13.2 human Y271-p 1880104204 DMSLDEAyRFVKEKR molecular association, regulation; intracellular localization; phosphorylation; enzymatic activity, induced transcription, inhibited; signaling pathway regulation JNK1(NOT_REPORTED); P38A(INDUCES) 36272649 1 0 0 dephosphorylates p38 MAPK or JNK, regulates MAPK signaling +FYB1 SLAP-130 Adaptor/scaffold O15117 2533 5p13.1 human Y595-p 452094 IEDDQEVyDDVAEQD molecular association, regulation; intracellular localization cell adhesion, induced; cell motility, altered; cytoskeletal reorganization; cell adhesion, altered SLP76(INDUCES); NCK1(INDUCES); NCK2(INDUCES) 10570256; 20661443; 23979596; 24769494; 30305305 6 2 63 involved in T cells activation +ATF1 ATF-1 Transcription factor P18846 466 12q13.12 human S41-p 15725600 SLSESEEsQDSSDSI molecular association, regulation; phosphorylation CBP(DISRUPTS) 20730097 2 0 0 primes for S47/S50/S51 phosphorylation +SET SET Apoptosis; DNA replication; DNA-binding; Inhibitor; Nuclear receptor co-regulator; Oncoprotein; Protein phosphatase, regulatory subunit Q01105 6418 9q34.11 human S7-p 455972 _MAPKRQsPLPPQKK phosphorylation cell cycle regulation; carcinogenesis, induced; cell motility, induced; cell growth, induced; apoptosis, inhibited 31097686 2 39 0 enhances Akt phosphorylation at T308 +Psma5 PSMA5 EC 3.4.25.1; Protease; Proteasome complex Q9Z2U1 26442 3|3 F2.3 mouse K203-ac 31910302 KSSLIILkQVMEEKL Proteasome protein degradation 24037710 0 1 0 +PPP1R12A MYPT1 Motility/polarity/chemotaxis; PHOSPHATASE; Protein phosphatase, regulatory subunit O14974 4659 12q21.2-q21.31 human S601-gl 1868585001 TKITTGSsSAGTQSS molecular association, regulation; phosphorylation cell cycle regulation PLK1(DISRUPTS) 32295844 1 1 0 inhibits CDK1-dependent phosphorylation at MYPT1 S473, regulates mitotic progression and centrosome integrity +SNAI1 Snail1 C2H2-type zinc finger protein; Transcription factor O95863 6615 20q13.13 human S82-p 11493501 ASLRLQEsPRVAELT protein stabilization; intracellular localization carcinogenesis, induced; cell motility, induced 23644467 3 0 0 +SLC29A1 SLC29A1 Membrane protein, integral; Membrane protein, multi-pass; Transporter; Transporter, SLC family Q99808 2030 6p21.1 human S254-p 486282 ETKLDLIsKGEEPRA Nucleoside_tran activity, induced; molecular association, regulation cell growth, induced SLC29A1(DISRUPTS) 17520485 2 10 0 +Rarg RARG iso2 DNA-binding; Nuclear receptor P18911-2 19411 15 F3|15 57.4 cM mouse S66-p 455543 SEEMVPSsPSPPPPP activity, induced; protein degradation transcription, altered 12032135 2 0 0 +MAFB MAFB DNA-binding; Oncoprotein; Transcription factor; Tumor suppressor Q9Y5Q3 9935 20q12 human K32-sm 12004404 DLLKFDVkKEPLGRA molecular association, regulation cell cycle regulation; carcinogenesis, induced; cell growth, induced; transcription, induced DNA(INDUCES) 27829226 2 0 0 +WRAP53 WRAP53 Q9BUR4 55135 17p13.1 human S64-p 482238 PVAGSAVsQELREGD molecular association, regulation DNA repair, induced H2AX(INDUCES) 27715493 1 3 0 +RAD52 RAD52 DNA repair, damage P43351 5893 12p13.33 human K190-ac 971232906 PLEVDLTkAKRQDLE molecular association, regulation; intracellular localization DNA repair, induced RFA2(INDUCES); RPA3(INDUCES); RAD51(INDUCES); RPA1(INDUCES) 29590107 1 1 0 accumulation of RAD52 at DSB sites +NR0B2 NR0B2 Nuclear receptor; Nuclear receptor co-regulator; Transcription, coactivator/corepressor Q15466 8431 1p36.11 human K170-ac 15211509 PKEYACLkGTILFNP Hormone_recep protein stabilization; intracellular localization transcription, inhibited 20516075 1 0 0 +Csnk1d CK1D EC 2.7.11.1; EC 2.7.11.26; KINASE; Kinase, protein; Protein kinase, CK1; Protein kinase, Ser/Thr (non-receptor) Q06486 64462 10q32.3 rat T397-p 3362909 QDTSRMStSQIPGRV enzymatic activity, inhibited 23861943 2 7 1 +SEC23B SEC23B Vesicle Q15437 10483 20p11.23 human S186-p 1394461700 SCEGISKsYVFRGTK Sec23_trunk protein stabilization; intracellular localization; protein conformation autophagy, induced SEC16A(INDUCES); SEC24B(INDUCES); SEC24A(INDUCES); SEC31A(INDUCES); SEC13(INDUCES); FBXW5(DISRUPTS) 30596474 1 0 0 Heterodimerization +PSMD2 PSMD2 Cell cycle regulation; Proteasome complex Q13200 5708 3q27.1 human S361-p 487471 ENNRFGGsGSQVDSA activity, induced; molecular association, regulation cell growth, induced RPT2(INDUCES) 31843888 1 38 3 regulates 26S proteosome activity and function +H3C1 H3 DNA-binding P68431 8350 6p22.2 human K36-m1 465523 APATGGVkKPHRYRP Histone cell cycle regulation; transcription, induced 16732292; 19521516 17 19 47 regulates Cdc45 association at replication origins during S -phase of cell cycle, H3K36me1 increases while H3K36me3 delays association +ME1 ME1 Carbohydrate Metabolism - pyruvate; EC 1.1.1.40; Oxidoreductase P48163 4199 6q14.2 human K337-ac 33350408 KIWLVDSkGLIVKGR Malic_M activity, induced; molecular association, regulation; intracellular localization; phosphorylation carcinogenesis, induced ME1(INDUCES) 31735643 1 3 0 decreases phosphorylation at S336; protein dimerization increased +CGAS cGAS EC 2.7.7.86 Q8N884 115004 6q13 human S435-p 1869388601 KHLDKFSsYHVKTAF Mab-21_C carcinogenesis, altered; transcription, induced 36574362 2 0 0 +CD274 PD-L1 Membrane protein, integral Q9NZQ7 29126 9p24.1 human K281-ub 1883389000 IQDTNSKkQSDTHLE protein degradation; ubiquitination 36376293 1 1 0 HUWE1 and TMUB1 antagonistically affect the degradation of PD-L1 +PRKCH PKCH EC 2.7.11.13; KINASE; Kinase, protein; Protein kinase, AGC; Protein kinase, Ser/Thr (non-receptor) P24723 5583 14q23.1 human S675-p 463347 QDEFRNFsYVSPELQ Pkinase_C protein stabilization; enzymatic activity, induced DNA repair, induced; cell motility, induced; cell growth, induced; apoptosis, inhibited 34593629 2 12 1 +LATS2 LATS2 EC 2.7.11.1; KINASE; Kinase, protein; Nuclear receptor co-regulator; Protein kinase, AGC; Protein kinase, Ser/Thr (non-receptor); Tumor suppressor Q9NRM7 26524 13q12.11 human S872-p 10945601 HQRCLAHsLVGTPNY Pkinase cell growth, induced; transcription, inhibited 29934311 5 3 15 +FCGR2B FCGR2B iso2 Cell surface; Membrane protein, integral; Oncoprotein P31994-2 2213 1q23.3 human Y273-p 448507 GAENTITySLLMHPD molecular association, regulation SHP-2(INDUCES) 27834631 4 2 1 +VIM Vimentin Cytoskeletal; Motility/polarity/chemotaxis P08670 7431 10p13 human S73-p 449025 SAVRLRSsVPGVRLL Filament_head molecular association, regulation; phosphorylation cytoskeletal reorganization Vimentin(DISRUPTS) 11895474; 14762106 14 53 32 increases phosphorylation of S5, S7, S8, S9, S10 +AKAP8 AKAP8 Adaptor/scaffold; Cell cycle regulation; Mitochondrial; RNA-binding O43823 10270 19p13.12 human Y150-p 15407467 HNPYRPSySYDYEFD molecular association, regulation 25770215 1 0 1 Phenylalanine mutants inhibited dissociation from nuclear structures; structural chromatin changes +PRKD1 PRKD1 Autophagy; EC 2.7.11.13; KINASE; Kinase, protein; Motility/polarity/chemotaxis; Protein kinase, CAMK; Protein kinase, Ser/Thr (non-receptor) Q15139 5587 14q12 human S738-p 448589 ARIIGEKsFRRSVVG Pkinase molecular association, regulation; ubiquitination; intracellular localization; enzymatic activity, induced cell cycle regulation; cell differentiation, altered; cell growth, induced; cell motility, altered; signaling pathway regulation; transcription, altered ASK1(INDUCES); IKKB(INDUCES); PKCD(INDUCES); JNK1(INDUCES) 11948398; 15024053; 15226414; 15755722; 16891660; 18337243; 18692497; 21285358; 34010649 58 14 20 inhibits ubiquitination and induces stability of Cyclin B1; PKD-MFF signaling +H3c1 H3 DNA-binding P68433 360198 13|13 A3.1 mouse R128-m1 1458612 PKDIQLArRIRGERA Histone chromatin organization, altered 19434510 0 3 0 regulation of senescence-related epigenetics modification +PML PML Nucleolus; Oncoprotein; SUMO LIGASE; SUMO conjugating system; SUMO ligase; Transcription factor; Tumor suppressor; Ubiquitin conjugating system P29590 5371 15q24.1 human S527-p 451472 PHLDGPPsPRSPVIG DUF3583 molecular association, regulation C/EBP-epsilon(INDUCES) 17989716 2 46 23 +Brsk1 BRSK1 EC 2.7.11.1; EC 2.7.11.26; KINASE; Kinase, protein; Protein kinase, CAMK; Protein kinase, Ser/Thr (non-receptor) B2DD29 499073 1q12 rat T189-p 456027 VGDSLLEtSCGSPHY Pkinase intracellular localization; enzymatic activity, induced 18324781; 22020259; 29698519 8 1 0 activation of Sad kinases in the axon during development; Sad kinases are required for the survival of cortical neurons +CCNH CCNH Cell cycle regulation P51946 902 5q14.3 human S5-p 456230 ___MYHNsSQKRHWT activity, inhibited transcription, altered; cell growth, altered 10993082 1 1 0 +AIMP1 SCYE1 Motility/polarity/chemotaxis; Translation; Translation regulation Q12904 9255 4q24 human S140-p 12440055 KKEKKQQsIAGSADS molecular association, regulation GRP94(DISRUPTS) 20510162 1 10 9 +Nphs1 NPHS1 Cell adhesion; Immunoglobulin superfamily; Membrane protein, integral Q9QZS7 54631 7|7 B1 mouse T1139-p 18507017 QWTGDRDtRSSTVST endocytosis, induced 35451598 2 0 0 +RPTOR Raptor Adaptor/scaffold Q8N122 57521 17q25.3 human S863-p 453732 LTQSAPAsPTNKGVH activity, induced; molecular association, regulation; intracellular localization; protein conformation; enzymatic activity, induced; phosphorylation cell cycle regulation RAG1(DISRUPTS) 19346248; 19864431; 21757713; 21900751; 22493283; 26588989 13 101 6 +APC2 APCL Membrane protein, peripheral O95996 10297 19p13.3 human S1160-p 33370500 QETPLVLsRCSSVSS APC_r protein degradation; molecular association, regulation transcription, inhibited axin 1(INDUCES) 24722208 1 0 0 +CAMK2D CAMK2D iso3 EC 2.7.11.17; KINASE; Kinase, protein; Protein kinase, CAMK; Protein kinase, Ser/Thr (non-receptor) Q13557-3 817 4q26 human S332-p 41591301 DGVKKRKsSSSVQMM intracellular localization; enzymatic activity, inhibited cytoskeletal reorganization 26163515 1 0 0 CaMKIID3, S332A significantly increased BDNF protein expression, nuclear localization, neurite extension, and survival. +Ctnnb1 CTNNB1 Actin-binding; Cell adhesion; Motility/polarity/chemotaxis; Nuclear receptor co-regulator; Oncoprotein; Transcription factor Q02248 12387 9 F4|9 72.19 cM mouse S60-p 1875093002 EEEDVDTsQVLYEWE molecular association, regulation cell cycle regulation ECT2(INDUCES) 34585824 2 0 0 +PRKAG1 AMPKG1 Autophagy; Protein kinase, regulatory subunit P54619 5571 12q13.12 human T284-p 1827354810 LKCYLHEtLETIINR CBS activity, induced; intracellular localization autophagy, induced 31983282 1 0 0 Phosphorylation at S192 and T284 plays important role in lysosomal activation of AMPK through lysosomal localization of the AMPK complex. +IFNAR2 IFNAR2 Membrane protein, integral; Receptor, cytokine P48551 3455 21q22.11 human Y411-p 455199 DPFPEEDySSTEGSG molecular association, regulation transcription, induced; signaling pathway regulation STAT2(DISRUPTS) 34813358 2 1 3 induces STAT phosphorylation and signaling +CHEK1 Chk1 EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, CAMK; Protein kinase, Ser/Thr (non-receptor); Tumor suppressor O14757 1111 11q24.2 human S280-p 447831 AKRPRVTsGGVSESP protein degradation; molecular association, regulation; intracellular localization; enzymatic activity, inhibited; enzymatic activity, induced cell cycle regulation; carcinogenesis, induced; DNA repair, inhibited 15107605; 15710331; 22357623; 23108403 11 27 145 +PTBP1 hnRNP I iso1 RNA splicing; RNA-binding P26599-1 5725 19p13.3 human T138-p 18010516 SNHKELKtDSSPNQA RRM_5 molecular association, regulation carcinogenesis, inhibited; RNA splicing, induced; cell differentiation, induced RNA(INDUCES) 35115536 1 5 0 +HSPA5 GRP78 Chaperone; Heat shock protein; KINASE P11021 3309 9q33.3 human K353-ac 13362602 LEDSDLKkSDIDEIV HSP70 molecular association, regulation; phosphorylation apoptosis, induced; signaling pathway regulation PERK(DISRUPTS) 20371724 1 1 0 induces phosphorylation of elf2a and activation of eIf2a-ATF4-CHOP pathway +SERPINA3 SERPINA3 Secreted; Secreted, signal peptide P01011 12 14q32.13 human K235-ac 464672 QSRFYLSkKKWVMVP Serpin molecular association, regulation DNA(INDUCES) 7782318 1 0 0 +Smurf1 SMURF1 EC 6.3.2.-; EC 6.3.2.19; Ligase; UBIQUITIN LIGASE; Ubiquitin conjugating system; Ubiquitin ligase Q9CUN6 75788 5|5 G2 mouse S148-p 27460454 DRIGGGGsVVDCRGL protein degradation; molecular association, regulation; ubiquitination cell differentiation, inhibited AML3(INDUCES); INSR(INDUCES) 26091038; 27052174 2 4 0 glucose homeostasis; ubiquitination and degradation of AML3 +NUMA1 NuMA-1 Cell cycle regulation; Motility/polarity/chemotaxis Q14980 4926 11q13.4 human Y1774-p 449717 VESLESLyFTPIPAR intracellular localization cell cycle regulation; cytoskeletal reorganization 22252550 1 10 85 spindle orientation +Elavl4 ELAVL4 RNA-binding Q61701 15572 4 C7|4 51.42 cM mouse T149-p 40248600 SGLPKTMtQKELEQL RRM_1 intracellular localization translation, induced 25692578 1 0 0 ELAVL4 transport to dendrites +TCERG1 TCERG1 RNA-binding; Spliceosome; Transcription factor O14776 10915 5q32 human K608-sm 13258710 QFSMSAIkEEQELME transcription, inhibited 20215116 1 1 0 sumoylation negatively regulates TCERG transcriptional activity +STK39 STLK3 EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, STE; Protein kinase, Ser/Thr (non-receptor) Q9UEW8 27347 2q24.3 human T231-p 456505 TRNKVRKtFVGTPCW Pkinase activity, induced; phosphorylation; enzymatic activity, induced 17190791; 18270262; 20442269; 22032326 12 5 51 Double knock in lacks its activity; induces phosphorylation of NKCC1 +DNM2 DYN2 EC 3.6.5.5; Hydrolase; Microtubule-binding; Motility/polarity/chemotaxis; Vesicle P50570 1785 19p13.2 human Y597-p 451200 NTEQRNVyKDLRQIE PH molecular association, regulation; intracellular localization; enzymatic activity, inhibited cell differentiation, inhibited; cytoskeletal reorganization; endocytosis, inhibited DYN2(INDUCES) 33113375 5 1 2 +Cdh1 CDH1 Cell adhesion; Membrane protein, integral; Motility/polarity/chemotaxis; UBIQUITIN LIGASE; Ubiquitin ligase P09803 12550 8 D3|8 53.18 cM mouse S853-p 465566 SLSSLNSsESDQDQD CADH_Y-type_LIR molecular association, regulation cell adhesion, altered CTNNB1(INDUCES) 10671552 1 0 0 +ZAP70 ZAP70 EC 2.7.10.2; KINASE; Kinase, protein; Protein kinase, TK; Protein kinase, tyrosine (non-receptor) P43403 7535 2q11.2 human Y492-p 447504 ALGADDSyYTARSAG PK_Tyr_Ser-Thr enzymatic activity, inhibited transcription, altered 8756661 7 13 422 inhibits Ca(2+) mobilization +ESR1 ER-alpha DNA-binding; Nuclear receptor; Transcription factor P03372 2099 6q25.1-q25.2 human K472-sm 27992518 TLKSLEEkDHIHRVL Hormone_recep transcription, induced; transcription, inhibited 22826433; 31141693 2 1 0 +ZNF622 ZNF622 Transcription factor Q969S3 90441 5p15.1 human T318-p 20765000 KGKSFYStEAVQAHM zf-C2H2_2 phosphorylation apoptosis, induced; transcription, induced; signaling pathway regulation 21771788 1 0 0 increases phosphorylation of ASK1 substrates. Suppress PDK1 signaling +Slc9a1 NHE1 Membrane protein, integral; Membrane protein, multi-pass; Motility/polarity/chemotaxis; Transporter; Transporter, SLC family P26431 24782 5q36 rat S775-p 475073 MIRSKEPsSPGTDDV activity, induced 19542484 6 2 0 +GATA4 GATA4 Motility/polarity/chemotaxis; Transcription factor P43694 2626 8p23.1 human K256-ub 1883526402 GINRPLIkPQRRLSA protein degradation; ubiquitination 35659652 1 1 0 negatively modulated cardiomyocyte hypertrophy +CAVIN1 PTRF Transcription initiation complex Q6NZI2 284119 17q21.2 human K289-ac 1873356104 VPAERREkLKTSRDK PTRF_SDPR molecular association, regulation; intracellular localization HSL(INDUCES) 28559430 1 1 0 induces lipolysis +TTK TTK Cancer Testis Antigen (CTA); EC 2.7.12.1; KINASE; Kinase, protein; Protein kinase, Other; Protein kinase, dual-specificity (non-receptor) P33981 7272 6q14.1 human S80-p 2846503 EKNSVPLsDALLNKL intracellular localization 21778823 3 7 0 +Prkaca PKACA EC 2.7.11.11; KINASE; Kinase, protein; Protein kinase, AGC; Protein kinase, Ser/Thr (non-receptor) P05132 18747 8|8 C2 mouse Y331-p 15230353 DTSNFDDyEEEEIRV enzymatic activity, inhibited; enzymatic activity, induced cell motility, induced; transcription, inhibited 21866565; 23447535 2 4 1 inhibition of the PKA and CREB-stimulated expression of the BCL2 gene +Map2k4 MKK4 EC 2.7.12.2; KINASE; Kinase, protein; Protein kinase, STE; Protein kinase, dual-specificity (non-receptor) P47809 26398 11 B3|11 40.53 cM mouse S78-p 447655 IERLRTHsIESSGKL molecular association, regulation; enzymatic activity, inhibited JNK1(DISRUPTS); MEK1(DISRUPTS) 17568772 8 16 87 +CDC25A CDC25A EC 3.1.3.48; Motility/polarity/chemotaxis; PHOSPHATASE; Protein phosphatase, dual-specificity P30304 993 3p21.31 human K150-ub 964504350 NEAFEFKkPVRPVSR M-inducer_phosp intracellular localization 36539837 1 1 0 +CDK2 CDK2 Cell cycle regulation; EC 2.7.11.22; KINASE; Kinase, protein; Protein kinase, CMGC; Protein kinase, Ser/Thr (non-receptor) P24941 1017 12q13.2 human T160-p 447739 GVPVRTYtHEVVTLW Pkinase activity, induced; protein conformation; enzymatic activity, induced cell cycle regulation; chromatin organization, altered CCNA1(INDUCES); CDKN3(DISRUPTS) 10931829; 12359725; 12475985; 1396589; 14551212; 14597612; 15355984; 15671017; 15824106; 17095507; 18593881; 19838212; 24662826 40 35 237 +PYCARD PYCARD Adaptor/scaffold; Tumor suppressor Q9ULZ3 29108 16p11.2 human Y60-p 1868827202 TDKLVSFyLETYGAE PYRIN activity, induced signaling pathway regulation 31333677 1 0 0 important for NLRP2 inflammasome complex formation and function +PLN PLB Inhibitor; Membrane protein, integral P26678 5350 6q22.31 human T17-p 448115 SAIRRAStIEMPQQA Phospholamban molecular association, regulation; protein conformation SERCA2(DISRUPTS); ATP2A1(DISRUPTS) 11854448; 18708665 75 12 63 +RAC1 RAC1 G protein; G protein, monomeric; G protein, monomeric, Rho; Motility/polarity/chemotaxis P63000 5879 7p22.1 human Y64-p 475227 DTAGQEDyDRLRPLS Ras molecular association, regulation cell adhesion, inhibited PAK1(DISRUPTS); ARHGEF7(DISRUPTS); RhoGDI alpha(INDUCES) 22163037; 34252134 2 1 36 inhibits cell spreading +Sik3 QSK EC 2.7.11.1; KINASE; Kinase, protein; Motility/polarity/chemotaxis; Protein kinase, CAMK; Protein kinase, Ser/Thr (non-receptor) Q6P4S6 70661 9|9 A5.2 mouse S551-p 468543 GPLGRRAsDGGANIQ molecular association, regulation; enzymatic activity, inhibited transcription, altered 14-3-3 beta(INDUCES) 30254177; 35997995; 36477539 7 48 120 +ACADVL ACADVL EC 1.3.8.9; Lipid Metabolism - fatty acid; Mitochondrial; Oxidoreductase P49748 37 17p13.1 human K298-ac 1194905 ITHGPPEkKMGIKAS Acyl-CoA_dh_M molecular association, regulation CRLS1(INDUCES) 25811481 1 2 9 both SIRT3 and SIRT5 KO show reduced afinity for CRLS1 +Tyrobp TYROBP Cell surface; Membrane protein, integral O54885 22177 7 B1|7 17.45 cM mouse Y103-p 451740 QGQRPEVySDLNTQR molecular association, regulation DOK3(INDUCES) 23962980 1 3 19 +BACH2 BACH2 DNA-binding; Transcription factor Q9BYV9 60468 6q15 human K580-sm 2798315 NQVRPQIkCEQSYGT intracellular localization 18201693 2 0 0 mobility of nuclear domains +BAX BAX Apoptosis; Membrane protein, integral; Mitochondrial; Tumor suppressor Q07812 581 19q13.33 human T167-p 465510 GLLSYFGtPTWQTVT activity, induced; intracellular localization; phosphorylation apoptosis, induced 15525785; 16709574 3 0 0 +Pde3a PDE3A EC 3.1.4.17; Membrane protein, integral; Membrane protein, multi-pass; Nucleotide Metabolism - purine; Phosphodiesterase Q9Z0X4 54611 6|6 G2 mouse S654-p 36132073 REPQRKAsACGTYTS enzymatic activity, inhibited 34252457 1 2 0 +PRKCQ PKCT EC 2.7.11.13; KINASE; Kinase, protein; Protein kinase, AGC; Protein kinase, Ser/Thr (non-receptor) Q04759 5588 10p15.1 human Y90-p 448588 SETTVELySLAERCR molecular association, regulation; intracellular localization; enzymatic activity, induced transcription, altered Other(INDUCES) 10652356; 17548359 3 0 0 +ARHGEF2 ARHGEF2 GEF; GEF, Rac/Rho; Motility/polarity/chemotaxis B2DCZ9 pig T653-p 449343 PGVELLLtSREPALP activity, induced; molecular association, regulation RHOA(INDUCES) 19261619 4 10 29 +Pou5f1 Oct4 DNA-binding; Transcription factor P20263 18999 17 B1|17 18.69 cM mouse T343-p 291887109 AFPSVPVtALGSPMH protein stabilization; molecular association, regulation; phosphorylation cell differentiation, inhibited; carcinogenesis, induced; cell motility, induced; signaling pathway regulation SOX2(INDUCES); SOX17(DISRUPTS) 28988986; 31996785 2 0 0 ESC Pluripotency; differentiation to ectoderm; induces AKT/GSK3? phosphorylation and Snail1 stabilization, (AKT/GSK3?/Snail1 signaling) +Pak1 PAK1 EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, STE; Protein kinase, Ser/Thr (non-receptor) O88643 18479 7 E1|7 53.57 cM mouse T109-p 14150103 QWARLLQtSNITKSE PBD enzymatic activity, inhibited 20400510 1 1 0 in vitro +Adam17 TACE EC 3.4.24.86; Membrane protein, integral; Motility/polarity/chemotaxis; Protease Q9Z0F8 11491 12 A1.3|12 8.3 cM mouse Y702-p 28706300 DKKLDKQyESLSLFH activity, induced; molecular association, regulation; intracellular localization FAK(INDUCES) 29361535 3 0 0 cell surface localization, TGFB1 upregulation +EIF4EBP1 4E-BP1 Translation; Translation initiation Q13541 1978 8p11.23 human T37-p 447497 PPGDYSTtPGGTLFS eIF_4EBP molecular association, regulation; activity, inhibited; phosphorylation carcinogenesis, induced; carcinogenesis, inhibited; cell growth, inhibited; signaling pathway regulation; translation, altered; cell growth, induced; apoptosis, inhibited; autophagy, inhibited; translation, induced 4E-BP1(DISRUPTS); mTOR(DISRUPTS); EIF4E(DISRUPTS) 12588975; 15051500; 19036825; 21602434; 21734039; 21750219; 21914810; 22071574; 23542178; 23584478; 24247720; 32094692; 34336098; 34546793; 34673774; 35626002; 35864174; 36652560; 37264081; 9465032 159 44 88 +TERT TERT iso3 DNA-binding; EC 2.7.7.49; Nucleolus; Transferase O14746-3 7015 5p15.33 human S921-p 1105513500 VLRLKCHsLFLDLQV apoptosis, inhibited 29748384 1 0 0 protects telomere damage, and results in delayed senescence and protection from apoptosis +TRPC1 TRPC1 Channel, calcium; Membrane protein, integral; Membrane protein, multi-pass P48995 7220 3q23 human T347-p 35542200 SGYRRKPtCKKIMTV signaling pathway regulation 25139746 1 0 0 inhibits 11,12-EET-induced smooth muscle hyperpolarization and relaxation +KCNQ2 Kv7.2 Channel, potassium; Membrane protein, integral; Membrane protein, multi-pass O43526 3785 20q13.33 human T217-p 457689 RMDRRGGtWKLLGSV Ion_trans; TM activity, induced 16319223 3 1 0 +Cald1 Caldesmon Actin-binding Q62736 25687 4q22 rat S527-p 448466 QSVDKVTsPTKV___ intracellular localization cytoskeletal reorganization 16289153 19 19 0 +APOBEC1 APOBEC1 Cell cycle regulation; EC 3.5.4.-; Hydrolase; RNA processing; RNA-binding P41238 339 12p13.31 human S72-p 450067 NFIKKFTsERDFHPS APOBEC4_like enzymatic activity, inhibited 11463337 1 0 0 +RANBP2 RANBP2 Adaptor/scaffold; EC 5.2.1.8; EC 6.3.2.-; Ligase; Nuclear export; Nucleoporin; SUMO LIGASE; SUMO conjugating system; SUMO ligase P49792 5903 2q13 human S2276-p 452314 FSFKSALsPSKSPAK molecular association, regulation; intracellular localization BICD2(INDUCES) 26051540 1 41 1 targets BicD2 to the NE of RGP cells to induce apical nuclear migration +Slc22a1 SLC22A1 Membrane protein, integral; Membrane protein, multi-pass; Transporter; Transporter, SLC family Q63089 24904 1q11 rat S328-p 455613 LCLEEDAsEKRSPSF Sugar_tr activity, induced 15829703 1 0 0 stimulates ASP+ uptake +Il22ra1 IL22RA1 Membrane protein, integral Q80XZ4 230828 4 D3|4 67.99 cM mouse K449-ub 33373904 PGDLSLQkVTSLGEG protein degradation 24742671 1 0 0 +Lrp6 LRP6 Membrane protein, integral; Receptor, misc. O88572 16974 6 G1|6 65.37 cM mouse S1579-p 23122945 TPRSQYLsAEENYES receptor internalization, induced; molecular association, regulation carcinogenesis, inhibited; signaling pathway regulation DAB2(INDUCES); CLTC(INDUCES) 22491013 1 0 1 Wnt/B-catenin signaling +KMT5A SETD8 Amino Acid Metabolism - lysine degradation; EC 2.1.1.43; METHYLTRANSFERASE; Methyltransferase; Methyltransferase, protein lysine Q9NQR1 387893 12q24.31 human K162-ac 31077504 QKIKDARkGPLVPFP protein stabilization; enzymatic activity, induced cell cycle regulation; chromatin organization, altered 23468428 1 0 0 +EPHA2 EphA2 EC 2.7.10.1; KINASE; Kinase, protein; Membrane protein, integral; Protein kinase, TK; Protein kinase, tyrosine (receptor) P29317 1969 1p36.13 human Y594-p 450860 TYVDPHTyEDPNQAV EphA2_TM molecular association, regulation; enzymatic activity, induced cell differentiation, altered; cell motility, altered VAV2(INDUCES); VAV3(INDUCES) 18387945 3 40 738 +PRKD1 PRKD1 Autophagy; EC 2.7.11.13; KINASE; Kinase, protein; Motility/polarity/chemotaxis; Protein kinase, CAMK; Protein kinase, Ser/Thr (non-receptor) Q15139 5587 14q12 human S223-p 455756 RTSSAELsTSAPDEP molecular association, regulation 14-3-3 beta(INDUCES) 15755722 1 0 0 +Alyref2 Refbp2 DNA-binding; RNA-binding Q9JJW6 56009 1|1 H3 mouse R173-m2 13906405 RGGMTRSrGSGGFGG FoP_duplication molecular association, regulation RNA(DISRUPTS) 20129943 1 1 0 +AR AR DNA-binding; Nuclear receptor; Transcription factor P10275 367 Xq12 human K631-me 31094540 GMTLGARkLKKLGNL protein conformation transcription, induced 21273441 1 0 0 +PDHA1 PDHA1 Amino Acid Metabolism - valine, leucine and isoleucine biosynthesis; Carbohydrate Metabolism - butanoate; Carbohydrate Metabolism - citrate (TCA) cycle; Carbohydrate Metabolism - glycolysis and gluconeogenesis; Carbohydrate Metabolism - pyruvate; EC 1.2.4.1; Mitochondrial; Oxidoreductase P08559 5160 Xp22.12 human S232-p 448257 NRYGMGTsVERAAAS E1_dh protein degradation; ubiquitination; enzymatic activity, inhibited carcinogenesis, induced; cell growth, induced; apoptosis, inhibited 11092882; 22289032; 25404640; 27357730; 27498883; 30697423; 30700909; 30797950; 32560271; 32993545; 34667275; 7782287 45 79 7 +DNAJC5 DNAJC5 Vesicle Q9H3Z4 80331 20q13.33 human S10-p 448129 DQRQRSLsTSGESLY molecular association, regulation exocytosis, induced; apoptosis, inhibited 14-3-3 zeta(INDUCES); 14-3-3 epsilon(INDUCES); 14-3-3 gamma(INDUCES); 14-3-3 eta(INDUCES); HSP70(INDUCES) 18951872; 24956274; 29167402 7 80 344 maintain normal conformation of SNAP25, protect dopaminergic neurons; modulate the rate of regulated exocytosis +RPS6KB1 p70S6K EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, AGC; Protein kinase, Ser/Thr (non-receptor); Translation P23443 6198 17q23.1 human S434-p 448356 SFEPKIRsPRRFIGS enzymatic activity, induced 7545671 28 1 0 +MRE11 MRE11A Cell cycle regulation; DNA repair, damage; DNA-binding; Deoxyribonuclease P49959 4361 11q21 human R580-me 2344816 GRGRRGGrGQNSASR intracellular localization 15970667 1 0 0 localizes in nucleus and associates with nuclear bodies and sites of DNA damage +CAMK2A CAMK2A EC 2.7.11.17; KINASE; Kinase, protein; Protein kinase, CAMK; Protein kinase, Ser/Thr (non-receptor) Q9UQM7 815 5q32 human T286-p 447797 SCMHRQEtVDCLKKF molecular association, regulation; intracellular localization; protein conformation; enzymatic activity, induced neural plasticity; cell motility, induced; cell growth, induced; transcription, induced; signaling pathway regulation; cell growth, altered MAP2(INDUCES); Calmodulin(INDUCES); GIT1(INDUCES); MBP(DISRUPTS); NMDAR2B(INDUCES); neurogranin(DISRUPTS) 15866054; 16140754; 16325579; 16436603; 20060891; 21768120; 23352984; 27605043; 33927400; 34667946; 35568036; 36144710 155 34 72 +MBD1 MBD1 Transcription factor Q9UIS9 4152 18q21.1 human K499-sm 3144812 VVALPQVkQEKADTQ molecular association, regulation transcription, induced SETDB1(DISRUPTS) 17066076 1 2 1 +CD247 CD3Z Membrane protein, integral; Receptor, misc. P20963 919 1q24.2 human Y83-p 449322 NLGRREEyDVLDKRR ITAM carcinogenesis, inhibited; signaling pathway regulation 30131370 3 10 277 +TOP2A TOP2A EC 5.99.1.3; Isomerase P11388 7153 17q21.2 human S1106-p 448761 DEEENEEsDNEKETE DNA_topoisoIV molecular association, regulation; enzymatic activity, induced DNA(INDUCES) 12569090; 19043076 3 43 0 +SET SET Apoptosis; DNA replication; DNA-binding; Inhibitor; Nuclear receptor co-regulator; Oncoprotein; Protein phosphatase, regulatory subunit Q01105 6418 9q34.11 human K68-sm 1877628100 QASEEILkVEQKYNK intracellular localization; phosphorylation 30767764 1 0 0 cytoplasmic retention, promotes tau phosphorylation, inhibits PP2A, cognitive deficits with tau pathology in mice +EIF4EBP1 4E-BP1 Translation; Translation initiation Q13541 1978 8p11.23 human T41-p 449366 YSTTPGGtLFSTTPG eIF_4EBP phosphorylation cell growth, induced; translation, induced EIF4E(DISRUPTS) 23584478; 24247720 2 24 54 T41 and T50 act as priming sites for T37/46; T41A and T50A mutants inhibited tumor growth and showed more cap-binding. +NPM/ALK NPM-ALK KINASE; Kinase, protein; Protein kinase, TK; Protein kinase, tyrosine (receptor) AAA58698 human Y338-p 27275110 FGMARDIyRASYYRK PK_Tyr_Ser-Thr enzymatic activity, induced 19887368 3 2 4 +HIF1A HIF1A Autophagy; DNA-binding; Transcription factor Q16665 3091 14q23.2 human K391-me 95155313 SSLFDKLkKEPDALT protein degradation; molecular association, regulation; acetylation; ubiquitination carcinogenesis, inhibited; transcription, inhibited VHL(INDUCES) 28534506 1 1 0 HIF1A methylation and acetylation increased ubiquitination; inhibits VEGF-induced tumor angiogenesis, induces HIF1A hydroxylation +G6PD G6PD Carbohydrate Metabolism - pentose phosphate pathway; Cell development/differentiation; EC 1.1.1.49; Other Amino Acids Metabolism - glutathione; Oxidoreductase P11413 2539 Xq28 human S40-p 1871700806 IFIIMGAsGDLAKKK G6PD_N protein stabilization; enzymatic activity, induced carcinogenesis, inhibited; apoptosis, induced 33398181 1 1 0 stabilizes HK2 +CTNNB1 CTNNB1 Actin-binding; Cell adhesion; Motility/polarity/chemotaxis; Nuclear receptor co-regulator; Oncoprotein; Transcription factor P35222 1499 3p22.1 human S33-p 447487 QQQSYLDsGIHSGAT protein degradation; protein stabilization; molecular association, regulation; ubiquitination; intracellular localization; activity, inhibited; neddylation cell cycle regulation; carcinogenesis, induced; carcinogenesis, inhibited; apoptosis, induced; cell growth, inhibited; transcription, induced; cell motility, inhibited; signaling pathway regulation; transcription, altered; cell adhesion, altered; cytoskeletal reorganization; transcription, inhibited; cell growth, altered CBLL1(INDUCES); TRAF2(DISRUPTS) 11751573; 12000790; 12027456; 15829978; 17018282; 17306568; 18573912; 19060929; 19061640; 19667122; 20300119; 20419129; 22025562; 22234184; 31911618; 32041324; 32046730; 33651074; 33832512; 34117362; 34290402; 34326276; 34749529; 35064015; 35065073; 35108540; 35320710; 35347116; 36575468; 36941998; 37369481; 37400529 112 3 2 +MAD2L1 MAD2L1 Cell cycle regulation Q13257 4085 4q27 human T187-p 22640014 EVRLRSFtTTIHKVN HORMA intracellular localization 23454898 1 0 1 +Apbb1 Fe65 Adaptor/scaffold; Apoptosis; Transcription regulation Q9QXJ1 11785 7 E3|7 55.9 cM mouse S459-p 13309858 VWGVGRDsGSNRDFA PID molecular association, regulation cell growth, induced; signaling pathway regulation ARF6(INDUCES) 36250347 1 1 0 induces ARF6-Rac1 signaling +HIF3A HIF3A Transcription factor; Tumor suppressor Q9Y2N7 64344 19q13.32 human K467-ub 486275 HRLFTSGkDTEAVET protein degradation 12538644 1 0 0 +CHEK2 Chk2 EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, CAMK; Protein kinase, Ser/Thr (non-receptor); Tumor suppressor O96017 11200 22q12.1 human T68-p 447491 SSLETVStQELYSIP molecular association, regulation; intracellular localization; protein conformation; phosphorylation; enzymatic activity, induced cell cycle regulation; carcinogenesis, induced; carcinogenesis, altered; carcinogenesis, inhibited; cell growth, inhibited; apoptosis, induced; signaling pathway regulation; DNA repair, induced; autophagy, induced; cell growth, induced; DNA repair, altered; apoptosis, inhibited; cytoskeletal reorganization; translation, induced PKM(INDUCES); PARP1(INDUCES); PLK1(INDUCES); ULK1(INDUCES); MDC1(INDUCES); ERK2(INDUCES); NBS1(INDUCES); Chk2(INDUCES) 10744722; 11025670; 11085506; 11390408; 11668173; 11901158; 12024051; 12607004; 15048074; 15342622; 15618221; 16150728; 16478990; 16794575; 16940182; 17283158; 17698850; 18948271; 18987440; 20372057; 20406977; 21772273; 21874023; 24844881; 25299772; 27753536; 30001349; 31597105; 33355621; 33851958; 33857133; 33901880; 33961649; 34244606; 34711990; 35513056; 35740063; 35999268; 36273494; 36692427 206 5 0 +Cfl1 Cofilin-1 Cytoskeletal; Motility/polarity/chemotaxis; Nuclear receptor co-regulator P18760 12631 19|19 A mouse S3-p 448444 _____MAsGVAVSDG activity, inhibited neural plasticity; cell motility, induced; cell motility, inhibited; cytoskeletal reorganization 11294912; 19553453; 22172670; 29114038; 34272687; 35325397; 35487245; 36044862; 36434054 97 69 3 +Notch1 Notch 1 Membrane protein, integral; Motility/polarity/chemotaxis; Oncoprotein; Receptor, misc.; Transcription factor Q01705 18128 2 A3|2 18.91 cM mouse K1771-ac 18899505 KVSEASKkKRREPLG protein stabilization; ubiquitination 21499261 1 1 0 +ERBB2 HER2 EC 2.7.10.1; KINASE; Kinase, protein; Membrane protein, integral; Oncoprotein; Protein kinase, TK; Protein kinase, tyrosine (receptor) P04626 2064 17q12 human Y1112-p 448674 DPSPLQRySEDPTVP protein degradation; molecular association, regulation CBL(INDUCES) 10910043 8 2 1 +Tp53 p53 Activator; DNA-binding; Motility/polarity/chemotaxis; Nuclear receptor co-regulator; Transcription factor; Tumor suppressor P02340 22059 11 B3|11 42.83 cM mouse K367-ac 458981 RAHSSYLkTKKGQST activity, induced transcription, induced 33323382 22 3 0 P53K Q/- mice died prematurely due to anemia, loss of hematopoiesis stem cells, Loss of stem cells in the testis, activation in p53 KQ/- mice without robust p53 stabilization,p53-KQ/- mutant leads to effective suppression of tumor development in a pancreatic ductal adenocarcinoma mouse model, mutant proteins extended the life-span of a PDAC mouse model +ARRB2 ARRB2 Adaptor/scaffold P32121 409 17p13.2 human T276-p 50247604 FCKVYTItPLLSDNR Arrestin_C receptor internalization, induced 26324936 2 1 0 +AFAP1 AFAP Adaptor/scaffold Q8N556 60312 4p16.1 human Y451-p 475079 TDPEALHyDYIDVEM molecular association, regulation Src(INDUCES) 9655255 1 0 0 Src Y529F Src mutant +Cttn Cortactin Actin-binding; Cytoskeletal; Motility/polarity/chemotaxis Q60598 13043 7|7 F5 mouse Y466-p 447703 TYTSEPVyETTEAPG molecular association, regulation; intracellular localization carcinogenesis, induced; cell motility, induced; cell motility, inhibited; cytoskeletal reorganization; signaling pathway regulation MTUS2(DISRUPTS); Arg(INDUCES); VAV2(INDUCES); Abl(INDUCES); smMLCK(INDUCES); FAK(DISRUPTS); N-WASP(INDUCES); RAC1(INDUCES) 12408982; 15169891; 17343955; 22078467; 22952866; 24891505; 25825709; 27339664; 27340123; 27451391; 28885660; 34439396 32 3 10 induces Vav2-Rac1 pathway +PLEK pleckstrin Lipid-binding P08567 5341 2p14 human T114-p 478034 QKFARKStRRSIRLP activity, induced 7559487 1 0 129 +Jun Jun Oncoprotein; Transcription factor P17325 24516 5q33 rat S73-p 447943 VGLLKLAsPELERLI Jun activity, induced; protein stabilization transcription, altered; cell growth, altered 12169099; 1749429 84 65 16 +STUB1 CHIP Adaptor/scaffold; EC 6.3.2.-; EC 6.3.2.19; Ligase; UBIQUITIN LIGASE; Ubiquitin conjugating system; Ubiquitin ligase Q9UNE7 10273 16p13.3 human K30-ub 603484814 SPSAQELkEQGNRLF molecular association, regulation 31619515 1 2 0 K30A mutation disrupts interactions with HSPs +SLFN11 SLFN11 Q7Z7L1 91607 17q12 human S753-p 1869008605 QVIRSNPsFNIPTGC activity, inhibited translation, induced 31395656 1 1 0 p24 expression and activity depend on S753 site +Tom1l1 Srcasm Adaptor/scaffold Q923U0 71943 11 D|11 55.47 cM mouse Y440-p 2263200 GDLQPPNyYEVMEFD molecular association, regulation cell growth, altered PIK3R1(INDUCES) 11711534; 17046829 2 1 3 mutation of this site promotes hyperproliferative phenotype +TNK1 TNK1 EC 2.7.10.2; KINASE; Kinase, protein; Protein kinase, TK; Protein kinase, tyrosine (non-receptor) Q13470 8711 17p13.1 human Y277-p 474456 LGGARGRyVMGGPRP PK_Tyr_Ser-Thr enzymatic activity, induced 36334623 2 2 2 +MYH7 MYH7 Motility/polarity/chemotaxis; Motor P12883 4625 14q11.2 human S210-p 27573390 DRSKKDQsPGKGTLE Myosin_head protein conformation 35502901 0 2 0 +Stat5a STAT5A DNA-binding; Motility/polarity/chemotaxis; Oncoprotein; Transcription factor P42230 20850 11 D|11 63.77 cM mouse S127-p 456898 VREANNCsSPAGVLV phosphorylation transcription, induced DNA(INDUCES) 15863494 1 2 0 Phosphorylation of S127 or S128 is required for transcription. Phosphorylation of S127/S128 required for phosphorylation on Y694 and binding of DNA. +GTF2I GTF2I iso2 DNA-binding; Transcription, coactivator/corepressor P78347-2 2969 7q11.23 human S743-p 457075 GVPFRRPsTFGIPRL GTF2I molecular association, regulation transcription, altered SMAD3(INDUCES) 16055503 2 14 266 +SYK Syk EC 2.7.10.2; KINASE; Kinase, protein; Protein kinase, TK; Protein kinase, tyrosine (non-receptor) P43405 6850 9q22.2 human K517-ub 12112713 ISDFGLSkALRADEN PK_Tyr_Ser-Thr molecular association, regulation; intracellular localization; protein conformation; enzymatic activity, induced SHP-1(DISRUPTS) 34362877 1 4 2 TRIM31 attenuated SHP-1 mediated WT SYK dephosphorylation; anti-fungal responses; SYK translocation to the membrane and binding with the C-type lectin receptors (CLRs) +UBE2I UBC9 EC 6.3.2.-; EC 6.3.2.19; Ligase; Nuclear receptor co-regulator; SUMO LIGASE; SUMO conjugating system; SUMO ligase; UBIQUITIN LIGASE; Ubiquitin conjugating system; Ubiquitin ligase P63279 7329 16p13.3 human K18-sm 60338002 QERKAWRkDHPFGFV UQ_con molecular association, regulation; intracellular localization signaling pathway regulation IPO13(INDUCES) 21139563; 27501389 2 1 0 TTR specifically modulates general protein SUMOylation +AR AR DNA-binding; Nuclear receptor; Transcription factor P10275 367 Xq12 human S83-p 448714 QQQQQETsPRQQQQQ Androgen_recep activity, induced; protein stabilization; molecular association, regulation; intracellular localization cell cycle regulation; carcinogenesis, induced; cell motility, induced; transcription, induced; signaling pathway regulation; transcription, altered; cell growth, induced; apoptosis, inhibited CDK5(INDUCES) DNA(INDUCES) 15684382; 21799006; 22275373; 23321516; 27902483; 29423094; 31429764; 33038264; 33932081; 33994848; 36482936 22 1 0 +PRKAG1 AMPKG1 Autophagy; Protein kinase, regulatory subunit P54619 5571 12q13.12 human S192-p 1827354809 KPEFMSKsLEELQIG CBS activity, induced; intracellular localization autophagy, induced 31983282 1 0 0 Phosphorylation at S192 and T284 plays important role in lysosomal activation of AMPK through lysosomal localization of the AMPK complex. +CNN3 calponin 3 Cytoskeletal; Motility/polarity/chemotaxis Q15417 1266 1p21.3 human S293-p 4776192 QGTGTNGsEISDSDY molecular association, regulation cytoskeletal reorganization 20861310 2 5 4 stimulates dissociation of calponin 3 from actin cytoskeleton (F-actin) +Pfkfb3 PFKFB3 Carbohydrate Metabolism - fructose and mannose; EC 2.7.1.105; EC 3.1.3.46; KINASE; Kinase, other; Motility/polarity/chemotaxis; PHOSPHATASE; Phosphatase (non-protein) Q9ESY2 170768 2|2 A1 mouse S467-p 468406 NSVTPLAsPEPTKKP protein stabilization; molecular association, regulation; enzymatic activity, induced carcinogenesis, induced GLUT2(INDUCES) 32580961 2 27 30 +AGO2 AGO2 EC 3.1.26.n2; RNA processing; RNA-binding Q9UKV8 27161 8q24.3 human S824-p 27443092 LVDKEHDsAEGSHTS molecular association, regulation; activity, inhibited transcription, inhibited RNA(DISRUPTS) 28114302 1 7 0 regulates miRNA silencing +Slco1a1 SLCO1A1 Membrane protein, integral; Transporter P46720 50572 4q44 rat S635-p 460720 FPGDIDSsATDHTEM molecular association, regulation; intracellular localization PDZK1(INDUCES) 21183661 1 1 0 plasma membrane distribution of SLCO1A1 requires interaction of its unphosphorylated form with PDZK1 +ZNF282 ZNF282 C2H2-type zinc finger protein Q9UDV7 8427 7q36.1 human K331-sm 31094514 QDLLSRIkQEEHQCV molecular association, regulation carcinogenesis, induced; transcription, induced CALCOCO1(INDUCES); ER-alpha(INDUCES) 22986521 1 0 0 +FOXM1 FOXM1 DNA-binding; Transcription factor Q08050 2305 12p13.33 human K603-ac 57807000 GPFKTPIkETLPISS activity, induced; protein stabilization; molecular association, regulation; phosphorylation carcinogenesis, induced; cell growth, induced; transcription, induced DNA(NOT_REPORTED) 27542221 1 1 0 +ADRA1B ADRA1B GPCR, family 1; Membrane protein, integral; Membrane protein, multi-pass; Receptor, GPCR P18841 101843941 hamster S410-p 451006 DSLDDSGsCMSGSQR receptor desensitization, altered 9353340 1 0 1 +GJA1 GJA1 Channel, misc.; Membrane protein, integral; Membrane protein, multi-pass; Motility/polarity/chemotaxis P17302 2697 6q22.31 human S368-p 447813 QRPSSRAsSRASSRP activity, induced; protein stabilization; molecular association, regulation; intracellular localization; protein conformation; activity, inhibited endocytosis, induced; carcinogenesis, inhibited; apoptosis, induced; cell motility, altered CLTA(INDUCES) 15534005; 17724204; 23828237; 24492000; 24742583; 31365296; 37231448 57 8 1 +FANCD2 FANCD2 DNA repair, damage Q9BXW9 2177 3p25.3 human K561-ub 486248 DMHLVIRkQLSSTVF FancD2 protein stabilization; molecular association, regulation; ubiquitination; intracellular localization cell cycle regulation; DNA repair, induced; transcription, induced; transcription, inhibited; signaling pathway regulation FOXO3A(INDUCES); FANCI(INDUCES); BRCA1(INDUCES); RAD51(INDUCES) DNA(INDUCES) 11239454; 12239151; 12239156; 15454491; 17304220; 20040763; 21355096; 22408259; 22855611; 23965832; 27264184; 27486975 20 12 52 +ERF ERF DNA-binding; Transcription factor P50548 2077 19q13.2 human S161-p 456969 SPTEDPRsPPACSSS intracellular localization cell cycle regulation 10330152 1 6 9 +RUNX1 AML1 DNA-binding; Oncoprotein; Transcription factor Q01196 861 21q22.12 human K188-ub 486731 QKLDDQTkPGSLSFS protein degradation; intracellular localization carcinogenesis, inhibited; cell growth, inhibited; transcription, inhibited 28536267 1 5 6 +IRF5 IRF5 DNA-binding; Transcription factor Q13568 3663 7q32.1 human S437-p 455994 FSGELSWsADSIRLQ activity, induced transcription, induced 12138184; 18836453 2 0 0 +Gsc GSC DNA-binding; Transcription factor Q02591 14836 12 E|12 54.32 cM mouse K238-sm 2887203 KWNKTSSkASPEKRE transcription, inhibited 18336814 1 0 0 SUMO modification inhibition is promoter specific +Cspg4 NG2 Cell adhesion; Membrane protein, integral Q00657 81651 8q24 rat T2256-p 454952 YLRKRNKtGKHDVQV intracellular localization cell motility, altered; cell adhesion, altered 15504744; 17591920 2 0 0 +Cd79a Ig-alpha Immunoglobulin superfamily; Membrane protein, integral P11911 12518 7 A3|7 13.49 cM mouse T203-p 21127302 ISRGLQGtYQDVGNL phosphorylation signaling pathway regulation 21841126 1 1 0 modulates T cell independent type II Ag response; phosphorylation at this site inhibits in vivo phosphorylation of tyrosine in Ig alpha +FMNL2 FMNL2 Cytoskeletal Q96PY5 114793 2q23.3 human S1016-p 3209661 MEQQDPKsPSHKSKR intracellular localization cell cycle regulation; cell adhesion, induced; cytoskeletal reorganization 29930204 1 24 0 +OSBP OSBP Lipid-binding P16258 rabbit S387-p 468343 GSNISGAsSDISLDE phosphorylation 11441133 2 33 1 S381 promotes subsequent phosphorylation of serines 384 and 387 +CDC6 CDC6 Cell cycle regulation Q99741 990 17q21.2 human K92-ac 8539502 PPHSHTLkGRRLVFD intracellular localization cell cycle regulation 19343071 1 0 0 +Nfatc2 NFAT1 DNA-binding; Transcription factor Q60591 18019 2 H3|2 88.91 cM mouse S282-p 447852 RSPSPQPsPHVALQD transcription, inhibited 11030334 0 1 0 +Ywhab 14-3-3 beta Adaptor/scaffold P35213 56011 3q42 rat S132-p 3136105 GDYFRYLsEVASGDN 14-3-3 molecular association, regulation RAF1(DISRUPTS); PKCZ(DISRUPTS) 10620507 1 2 0 +Syngap1 SynGAP iso3 GAP; GAP, Ras Q9QUH6-3 192117 20p12 rat S390-p 18710209 KGKEEVAsALVHILQ molecular association, regulation; intracellular localization HRas(INDUCES) 21382555 1 1 1 +PML PML Nucleolus; Oncoprotein; SUMO LIGASE; SUMO conjugating system; SUMO ligase; Transcription factor; Tumor suppressor; Ubiquitin conjugating system P29590 5371 15q24.1 human K487-ac 4659502 SQTQCPRkVIKMESE DUF3583 sumoylation cell cycle regulation; apoptosis, induced 18621739 2 0 1 +Kcnj11 Kir6.2 Channel, potassium; Membrane protein, integral; Membrane protein, multi-pass Q61743 16514 7 B3|7 29.66 cM mouse T180-p 450652 QAHRRAEtLIFSKHA activity, induced 10908656 2 0 0 PKC-mediated activation of ATP-sensitive potassium channels involves phosphorylation of the Kir6.2 subunit at T180. +POLR2A POLR2A EC 2.7.7.48; EC 2.7.7.6; Nucleotide Metabolism - purine; Nucleotide Metabolism - pyrimidine; Transcription initiation complex; Transferase P24928 5430 17p13.1 human T1540-p 1239966000 PSVGSGMtPGAAGFS molecular association, regulation transcription, induced SPT6(INDUCES) 30135578 1 1 0 +KAT7 MYST2 ACETYLTRANSFERASE; Acetyltransferase; EC 2.3.1.48; Nuclear receptor co-regulator; Transcription, coactivator/corepressor O95251 11143 17q21.33 human T88-p 468239 QQQPTPVtPKKYPLR cell growth, induced 23955388 2 42 46 increase in mammosphere formation +DDR2 DDR2 EC 2.7.10.1; KINASE; Kinase, protein; Membrane protein, integral; Protein kinase, TK; Protein kinase, tyrosine (receptor) Q16832 4921 1q23.3 human Y471-p 451276 EQGSNSTyDRIFPLR molecular association, regulation SHC1(INDUCES) 11884411 1 2 12 +Ptpa PPP2R4 EC 5.2.1.8; Motility/polarity/chemotaxis; Protein phosphatase, regulatory subunit P58389 110854 2 B|2 21.71 cM mouse K302-ub 573769714 YKAECLEkFPVIQHF PTPA protein degradation; ubiquitination; methylation cytoskeletal reorganization 31160454 1 3 0 mediating the effects of UBE3A on spine morphology. +TERF2 TRF2 DNA repair, damage; DNA-binding Q15554 7014 16q22.1 human K335-ac 27581522 MTLKAAFkTLSGAQD TERF2_RBM protein stabilization; molecular association, regulation cell cycle regulation; cell growth, altered DNA(INDUCES) 23307557 1 2 0 regulates cell proliferation and cell cycle; binding to telomere; loss of K335 acetylation induces DNA damage foci at telomeres +PML PML Nucleolus; Oncoprotein; SUMO LIGASE; SUMO conjugating system; SUMO ligase; Transcription factor; Tumor suppressor; Ubiquitin conjugating system P29590 5371 15q24.1 human S530-p 451473 DGPPSPRsPVIGSEV DUF3583 molecular association, regulation C/EBP-epsilon(INDUCES) 17989716 2 29 17 +FOXM1 FOXM1 DNA-binding; Transcription factor Q08050 2305 12p13.33 human T600-p 478080 EVGGPFKtPIKETLP molecular association, regulation; protein stabilization cell cycle regulation; transcription, induced CDC25A(INDUCES) 22094256; 23240008; 33657372 4 1 2 +RELA NFkB-p65 DNA-binding; Nuclear receptor co-regulator; Transcription factor Q04206 5970 11q13.1 human K122-ub 25087018 NLGIQCVkKRDLEQA RHD_DNA_bind protein degradation; molecular association, regulation carcinogenesis, inhibited; cell growth, inhibited; cell motility, inhibited; transcription, inhibited DNA(DISRUPTS) 21706061; 34465889 2 2 0 +NEK2 NEK2 EC 2.7.11.1; KINASE; Kinase, protein; Nucleolus; Protein kinase, Other; Protein kinase, Ser/Thr (non-receptor) P51955 4751 1q32.3 human T179-p 12574601 FAKTFVGtPYYMSPE Pkinase enzymatic activity, inhibited 17197699 1 2 0 +Slc12a5 KCC2 Membrane protein, integral; Membrane protein, multi-pass; Transporter; Transporter, SLC family Q91V14 57138 2|2 H3 mouse T929-p 10045603 SAYTYEKtLVMEQRS SLC12 activity, inhibited cell growth, altered 31615901 7 4 0 necessary for neuronal proliferation and /or migration in developing forebrain +NFKB1 NFkB-p105 DNA-binding; Transcription factor P19838 4790 4q24 human S893-p 451564 EVIQAASsPVKTTSQ activity, induced; protein processing 8522173 2 10 6 Mutation of this site retards the proteolytic processing of p105 that generates active NFkB. +LIN52 LIN52 Cell cycle regulation Q52LA3 91750 14q24.3 human S28-p 4758466 FEKLDRAsPDLWPEQ LIN52 protein degradation; molecular association, regulation cell cycle regulation; cell growth, inhibited; transcription, inhibited P130Cas(INDUCES) 21498570; 30206359; 34728711 3 25 2 +PDPK1 PDK1 EC 2.7.11.1; KINASE; Kinase, protein; Nuclear receptor co-regulator; Protein kinase, AGC; Protein kinase, Ser/Thr (non-receptor) O15530 5170 16p13.3 human T513-p 450132 PEAKNFKtFFVHTPN PH_3 molecular association, regulation; intracellular localization; protein conformation; enzymatic activity, induced PDK1(DISRUPTS) Other(DISRUPTS) 20978239; 23745598 5 4 0 lowers affinity for PIP3 binding +FOXM1 FOXM1 iso2 DNA-binding; Transcription factor Q08050-2 2305 12p13.33 human K445-sm 31898501 LLPVQTIkEEEIQPG protein degradation transcription, inhibited 25533473 2 2 0 +Gatad2a GATAD2A Transcription factor Q8CHY6 234366 8|8 B3.3 mouse S96-p 453704 KSEKRPPsPDVIVLS molecular association, regulation HDAC2(INDUCES) 28346453 1 80 33 +Hck Hck EC 2.7.10.2; KINASE; Kinase, protein; Oncoprotein; Protein kinase, TK; Protein kinase, tyrosine (non-receptor) P08103 15162 2 H1|2 75.41 cM mouse Y50-p 448169 ANQKGPVyVPDPTSS enzymatic activity, induced 10934191 1 4 72 +MPZL1 PZR Adaptor/scaffold; Membrane protein, integral O95297 9019 1q24.2 human Y241-p 451272 SHQGPVIyAQLDHSG molecular association, regulation cell adhesion, altered SHP-2(INDUCES) 11751924 1 17 448 +EPHB1 EphB1 EC 2.7.10.1; KINASE; Kinase, protein; Membrane protein, integral; Protein kinase, TK; Protein kinase, tyrosine (receptor) P54762 2047 3q22.2 human Y594-p 449995 GSPGMKIyIDPFTYE EphA2_TM molecular association, regulation; phosphorylation cell motility, altered; cell adhesion, altered NCK1(INDUCES) 10669731; 12223469; 9430661 5 16 117 JNK1 activation; phosphorylation of Grb7; Stimulation of EphB1 and EphB2 induced a complex between Nik/Nck1, Dok1, RasGAP, and an unidentified 145-kDa tyrosine-phosphorylated protein. +Tmcc3 TMCC3 Membrane protein, integral; Membrane protein, multi-pass Q8R310 319880 10|10 C2 mouse S216-p 4033272 LIRNKFGsADNIAHL Tmemb_cc2 carcinogenesis, induced; cell motility, induced 33742122 0 41 0 +CCDC50 CCDC50 Inhibitor Q8IVM0 152137 3q28 human Y279-p 462101 TDGEDADyTHFTNQQ phosphorylation apoptosis, inhibited; cell growth, altered 19059208 1 10 83 ; inhibits NF-kB activity; inhibits phosphorylation of IKKbeta through TNFalpha +IRS1 IRS1 Adaptor/scaffold; Motility/polarity/chemotaxis P35568 3667 2q36.3 human S312-p 447558 TESITATsPASMVGG protein degradation; molecular association, regulation; intracellular localization apoptosis, altered; cell motility, inhibited IKKA(DISRUPTS); IKKB(DISRUPTS) 12351658; 12510059; 16914728; 18794113; 37298039 77 14 0 +STING1 STING Apoptosis; Endoplasmic reticulum; Membrane protein, integral; Membrane protein, multi-pass; Mitochondrial Q86WV6 340061 5q31.2 human K370-ub 964547962 LLISGMEkPLPLRTD protein degradation 35871231 1 1 0 UFL1 reduces STING ubiquitination +TXN TXN Nuclear receptor co-regulator P10599 7295 9q31.3 human T100-p 457590 NKEKLEAtINELV__ Thioredoxin intracellular localization apoptosis, altered 20619274 1 1 0 +CTNNB1 CTNNB1 Actin-binding; Cell adhesion; Motility/polarity/chemotaxis; Nuclear receptor co-regulator; Oncoprotein; Transcription factor P35222 1499 3p22.1 human S715-p 25288326 GYRQDDPsYRSFHSG protein degradation; molecular association, regulation TIF1G(INDUCES) 25639486 1 0 1 TIF1G abolishes tumorigenesis +Asic3 ASIC3 Channel, cation; Membrane protein, integral; Membrane protein, multi-pass; Transporter; Transporter, ion channel O35240 286920 4q11 rat S523-p 12518703 VTKTLSAsHRTCYLV activity, induced 14976185 1 0 0 channel activation +FOCAD FOCAD Membrane protein, integral; Membrane protein, multi-pass Q5VW36 54914 9p21.3 human K583-ub 21177596 GKEVQWEkLIAKAAS DUF3730 protein degradation 36184622 0 8 0 +TSPYL5 TSPYL5 Q86VY4 85453 8q22.1 human T120-p 3245189 SERLAADtVFVGTAG sumoylation; protein stabilization; ubiquitination; intracellular localization carcinogenesis, induced; cell growth, induced; transcription, altered; signaling pathway regulation 34163000 1 1 0 inhibits ubiquitination, rgulates AKT/TSPYL5/PTEN cyclic signaling +LHX3 LHX3 DNA-binding; Transcription factor Q9UBR4 8022 9q34.3 human S71-p 455295 PLAERCFsRGESVYC LIM activity, induced transcription, induced 15517599 1 0 0 no change in binding to DNA or to certain proteins (NLI, PIT1, or MRG1) +HSPA5 GRP78 Chaperone; Heat shock protein; KINASE P11021 3309 9q33.3 human K585-m3 12261706 DKEKLGGkLSSEDKE HSP70 protein degradation 28912266 3 6 5 METTL21A-dependent tri-methylated GRP78 is degraded, while ERS leads to biosynthesis of non-trimethylated GRP78. +Scn1b SCN1B Channel, sodium; Membrane protein, integral Q00954 29686 1q21 rat Y200-p 455547 AQENASEyLAITSES molecular association, regulation ANK1(DISRUPTS) 11997395 2 0 0 +CERS4 LASS4 DNA-binding; Membrane protein, integral; Membrane protein, multi-pass Q9HA82 79603 19p13.2 human S350-p 7102764 DVEESDSsEEAAAAQ enzymatic activity, induced 26887952 1 7 0 +ACVR1B ALK4 EC 2.7.11.30; KINASE; Kinase, protein; Membrane protein, integral; Protein kinase, Ser/Thr (receptor); Protein kinase, TKL P36896 91 12q13.13 human T206-p 138972400 VQRTVARtIVLQEII cell growth, inhibited; transcription, induced 28650473 1 0 0 +Stk3 MST2 Autophagy; EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, STE; Protein kinase, Ser/Thr (non-receptor) O54748 65189 7q22 rat T180-p 448899 DTMAKRNtVIGTPFW Pkinase enzymatic activity, induced 12554736 15 0 5 +AMFR AMFR EC 6.3.2.-; EC 6.3.2.19; Endoplasmic reticulum; Ligase; Membrane protein, integral; Membrane protein, multi-pass; Motility/polarity/chemotaxis; Receptor, misc.; UBIQUITIN LIGASE; Ubiquitin conjugating system; Ubiquitin ligase Q9UKV5 267 16q13 human S516-p 3148446 SIRPALNsPVERPSS protein degradation; ubiquitination 28528366 1 9 0 +SCYL1 SCYL1 KINASE; Kinase, protein; Protein kinase, Other; Protein kinase, Ser/Thr (non-receptor) Q96KG9 57410 11q13.1 human S754-p 5208514 STQPRPDsWGEDNWE intracellular localization exocytosis, inhibited 35948564 1 17 73 +Cacna1d CACNA1D Channel, calcium; Membrane protein, integral; Membrane protein, multi-pass P27732 29716 16p16 rat S1947-p 1827354811 IGYDSRRsPRRRLLP CAC1F_C activity, inhibited 31983427 1 0 0 Regulates Cav1.3 activity +VHL VHL Tumor suppressor; UBIQUITIN LIGASE; Ubiquitin ligase P40337 7428 3p25.3 human S68-p 469116 PVLRSVNsREPSQVI VHL molecular association, regulation cytoskeletal reorganization HIF2A(DISRUPTS) 16847331 2 2 0 destabilizes microtubules +Fgf23 FGF23 Cytokine; Secreted; Secreted, signal peptide Q9EPC2 64654 6|6 F3 mouse S212-p 36400702 SCSRELPsAEEGGPA protein stabilization exocytosis, induced 25195776 1 1 0 +Spast spastin Cytoskeletal; EC 3.6.4.3; Membrane protein, integral B2RYN7 362700 6q13 rat S210-p 4783443 PLTHASNsLPRSKTV molecular association, regulation; intracellular localization neural plasticity GluR2(INDUCES) 35418834 1 19 2 +ANTXR2 ANTXR2 Membrane protein, integral; Receptor, misc. P58335 118429 4q21.21 human Y463-p 13320000 WALLRRQyDRVSLMR Ant_C ubiquitination 20080640 1 0 0 +FOSL2 FRA2 DNA-binding; Transcription factor P15408 2355 2p23.2 human K104-m1 37038500 LPRPGVIkTIGTTVG methylation cell differentiation, induced; transcription, induced; transcription, inhibited 25547114 1 1 0 +Pik3c3 PIK3C3 Autophagy; Carbohydrate Metabolism - inositol phosphate; EC 2.7.1.137; Kinase, lipid; Motility/polarity/chemotaxis Q6PF93 225326 18|18 B1 mouse K840-sm 31077507 LEPDKTVkKVQDKFR molecular association, regulation cell differentiation, altered; autophagy, induced 30703554 2 0 0 dedifferentiation, pulmonary vascular remodeling and pulmonary arterial hypertension (PAH) +Irs1 IRS1 Adaptor/scaffold; Motility/polarity/chemotaxis P35570 25467 9q34 rat S336-p 455324 GTMSRPAsVDGSPVS phosphorylation 15574412 3 6 9 primes S332 for phosphorylation by GSK3B; decreases tyrosine phosphorylation of IRS-1 and Akt1 phosphorylation upon insulin stimulation +EIF6 EIF6 Nucleolus; Translation; Translation initiation P56537 3692 20q11.22 human S174-p 17535702 IEDQDELsSLLQVPL eIF-6 intracellular localization 21084295 1 1 0 required for the nuclear export of eIF6 +G6PD G6PD Carbohydrate Metabolism - pentose phosphate pathway; Cell development/differentiation; EC 1.1.1.49; Other Amino Acids Metabolism - glutathione; Oxidoreductase P11413 2539 Xq28 human K432-ac 11320995 GNRYKNVkLPDAYER G6PD_C enzymatic activity, altered 37798264 1 6 5 +Gab2 GAB2 Adaptor/scaffold Q9Z1S8 14389 7|7 E1 mouse S469-p 4825114 QSVYIPMsPGPHHFD molecular association, regulation PIK3R1(DISRUPTS) 28096188 1 4 3 +NKX3-1 NKX3-1 DNA-binding; Transcription factor; Tumor suppressor Q99801 4824 8p21.2 human T89-p 464287 AAPEEAEtLAETEPE protein stabilization 16581776 2 1 0 +TGFBR2 TGFBR2 EC 2.7.11.30; KINASE; Kinase, protein; Membrane protein, integral; Oncoprotein; Protein kinase, Ser/Thr (receptor); Protein kinase, TKL P37173 7048 3p24.1 human Y470-p 34729902 AVGEVKDyEPPFGSK PK_Tyr_Ser-Thr activity, induced; phosphorylation signaling pathway regulation 24983314 1 0 0 regulates cell morphology, induces phosphorylation and activation of SMAD3, expression of E-cadherin, collagen synthesis and renal fibrosis; regulates TGF-beta1-mediated activation of canonical signaling +FOXA2 FOXA2 DNA-binding; Transcription factor Q9Y261 3170 20p11.21 human K274-ac 3649004 AGAAGSGkKAAAGAQ protein stabilization transcription, induced 24875183 1 1 6 +AANAT AA-NAT ACETYLTRANSFERASE; Acetyltransferase; Amino Acid Metabolism - tryptophan; EC 2.3.1.87 Q29495 443531 sheep T31-p 452141 PGRQRRHtLPANEFR molecular association, regulation; enzymatic activity, induced 14-3-3 zeta(INDUCES) 15644438; 18771288 4 0 0 +DBI DBI Lipid-binding Q8WN94 100008823 rabbit T36-p 2833501 YSHYKQAtVGDVNTE ACBP molecular association, regulation GABRA1(INDUCES) 18194441 1 1 0 +ATRIP ATRIP Cell cycle regulation; DNA repair, damage; DNA-binding Q8WXE1 84126 3p21.31 human K32-ac 6217746 GTGHPPSkRARGFSA cell cycle regulation; DNA repair, inhibited DNA(DISRUPTS) 26854234 2 1 3 ATR checkpoint +Nolc1 NOLC1 Nucleolus; RNA-binding; Transcription, coactivator/corepressor P41777 64896 1q54 rat S627-p 455685 KKGEKRAsSPFRRVR activity, induced transcription, altered 12167624 1 22 3 +Lcp2 SLP76 Adaptor/scaffold Q60787 16822 11|11 A4 mouse S376-p 476784 IGFQQSAsLPPYFSQ protein degradation; molecular association, regulation; ubiquitination transcription, inhibited LAT(DISRUPTS); 14-3-3 zeta(INDUCES) 22105350; 22902619 5 1 0 phosphorylation causes a disruption of microclusters and prevents T cell activation +CCNF CCNF Cell cycle regulation P41002 899 16p13.3 human S621-p 288031702 GYEGDQEsEGEKEGD activity, inhibited 29021214 1 1 0 regulation the E3 ligase activity of cyclin F +RNF146 RNF146 EC 6.3.2.-; EC 6.3.2.19; UBIQUITIN LIGASE; Ubiquitin conjugating system; Ubiquitin ligase Q9NTX7 81847 6q22.33 human K20-sm 1883827100 NMLPTNRkANESCSN protein degradation cell growth, induced 37029301 1 0 0 degradation of Axin and upregulation of ?-catenin, progression of HCC cells, abolishing RNF146 SUMOylation inhibits HCC cell tumorigenesis +PKM PKM Carbohydrate Metabolism - glycolysis and gluconeogenesis; Carbohydrate Metabolism - pyruvate; EC 2.7.1.40; KINASE; Kinase, other; Mitochondrial; Nucleotide Metabolism - purine P14618 5315 15q23 human K62-ac 11318760 SRSVETLkEMIKSGM PK molecular association, regulation; intracellular localization cell cycle regulation; cell growth, inhibited; transcription, inhibited CTNNB1(DISRUPTS) 33279948 2 7 1 K63 deacetylation induces nuclear translocation. +PFKFB4 PFKFB4 Carbohydrate Metabolism - fructose and mannose; EC 2.7.1.105; EC 3.1.3.46; Kinase, other; Motility/polarity/chemotaxis; Phosphatase (non-protein) Q16877 5210 3p21.31 human T140-p 1879811800 TTRERRAtIFNFGEQ protein stabilization cell motility, induced; cell growth, induced 36109523 1 0 0 +FHL2 FHL2 Motility/polarity/chemotaxis; Nuclear receptor co-regulator; Transcription, coactivator/corepressor Q14192 2274 2q12.2 human Y236-p 25292373 SGLGGTKyISFEERQ LIM cell cycle regulation; cell growth, inhibited 33932144 1 1 9 +NR4A2 NR4A2 DNA-binding; Nuclear receptor P43354 4929 2q24.1 human K577-sm 2407418 LQRIFYLkLEDLVPP Hormone_recep transcription, inhibited 19345186 2 0 0 +NRAS NRas G protein; G protein, monomeric; G protein, monomeric, Ras; Motility/polarity/chemotaxis; Oncoprotein P01111 4893 1p13.2 human S89-p 1867735502 FAINNSKsFADINLY Ras activity, induced; molecular association, regulation; phosphorylation carcinogenesis, induced; cell growth, induced; apoptosis, inhibited; signaling pathway regulation BRAF(INDUCES); RAF1(INDUCES); PIK3CA(INDUCES) 30712867; 32156748 2 1 0 induces phosphorylation of ERK, MEK, Akt and hence NRas signaling; induces NRas signaling pathway +SCML2 SCML2 Transcription factor Q9UQR0 10389 Xp22.13 human S590-p 3216624 SPLVGDIsPKSSPHE cell cycle regulation 24358021 1 29 5 +PDCL PhLP G protein regulator, misc. Q13371 5082 9q33.2 human S20-p 448825 LQYYYSSsEDEDSDH molecular association, regulation G-gamma 2(INDUCES); CCTA(INDUCES) 15889144; 16717095 4 6 3 PhLP phosphorylation at S18-S20 induces association of G-gamma(2) with a G-beta(1)/PhLP complex. These PhLP phosphorylations are also required for normal G-beta/G-gamma dimer assembly.; facilitates dimerization of subunits beta and gamma of G-protein +IKBKG IKKG Adaptor/scaffold; Protein kinase, regulatory subunit Q9Y6K9 8517 Xq28 human K326-ub 7482002 REKLAEKkELLQEQL CC2-LZ protein degradation signaling pathway regulation 17728323; 32935379 2 2 0 +UVRAG UVRAG Autophagy Q9P2Y5 7405 11q13.5 human Y523-p 4761501 YKTPPPSyNSALAQP molecular association, regulation SMURF1(INDUCES) 30686098 1 0 3 +HJURP HJURP Histone-binding; Nucleolus Q8NCD3 55355 2q37.1 human S486-p 482923 GLETRRLsLPSSKAK molecular association, regulation 14-3-3 gamma(INDUCES) 17256767 1 19 3 +Igf2bp1 IGF2BP1 RNA-binding; Translation Q8CGX0 303477 10q26 rat Y396-p 458348 SVTGAAPyGSFMQAP translation, altered 20631164 6 0 0 +ACSL4 ACSL4 EC 6.2.1.3; Ligase; Lipid Metabolism - fatty acid; Membrane protein, integral O60488 2182 Xq23 human T328-p 1876129100 LAHVLELtAEISCFT AMP-binding molecular association, regulation; enzymatic activity, induced carcinogenesis, inhibited ACSL4(INDUCES) 35027735 1 0 0 +CDC14A CDC14A EC 3.1.3.16; EC 3.1.3.48; Motility/polarity/chemotaxis; PHOSPHATASE; Protein phosphatase, dual-specificity Q9UNH5 8556 1p21.2 human S484-p 31085757 INSRLASsLGNLNAA cell cycle regulation; autophagy, induced 33090408 1 2 0 +Srr SRR Amino Acid Metabolism - glycine, serine and threonine; EC 4.3.1.17; EC 4.3.1.18; EC 5.1.1.18; Isomerase Q76EQ0 rat T227-p 7594900 SKLKGELtPNLHPPE PALP intracellular localization 19380732 2 2 0 regulates membrane-binding of Srr +AHR AHR DNA-binding; Transcription factor P35869 196 7p21.1 human S36-p 451413 EGIKSNPsKRHRDRL HLH intracellular localization carcinogenesis, induced; apoptosis, inhibited; transcription, altered 15063792; 35405096 2 1 0 +MYC Myc DNA-binding; Nucleolus; Oncoprotein; Transcription factor P01106 4609 8q24.21 human K338-sm 40724408 RKDYPAAkRVKLDSV Myc_N protein degradation; ubiquitination transcription, inhibited 25895136 1 2 0 +Pdk1 PDHK1 EC 2.7.11.2; KINASE; Kinase, protein; Mitochondrial; Protein kinase, Ser/Thr (non-receptor); Protein kinase, atypical Q8BFP9 228026 2|2 C3 mouse Y241-p 462384 ARRLCDLyYVNSPEL cell growth, induced 22195962 2 1 2 Y to F mutants show decreased proliferation under hypoxia and increased oxidative phosphorylation. +Adcy2 ADCY2 Adenylyl cyclase; EC 4.6.1.1; Lyase; Membrane protein, integral; Membrane protein, multi-pass; Nucleotide Metabolism - purine; Transporter; Transporter, aquaporin family P26769 81636 1p11 rat T1057-p 451157 QTLGYTCtCRGIINV Guanylate_cyc activity, induced 9366262 2 0 0 +Net1 NET1 GEF; GEF, Rac/Rho; Motility/polarity/chemotaxis; Oncoprotein Q9Z206 56349 13|13 A1 mouse S152-p 455600 PTPTKRRsSALWSEM activity, inhibited cytoskeletal reorganization 15684429 1 0 0 inhibits guanine nucleotide exhange activity toward RhoA, inhibits actin stress fiber formation +Cbl CBL Adaptor/scaffold; EC 6.3.2.-; EC 6.3.2.19; Ligase; Motility/polarity/chemotaxis; Oncoprotein; UBIQUITIN LIGASE; Ubiquitin conjugating system; Ubiquitin ligase P22682 12402 9 A5.1-A5.2|9 24.72 cM mouse Y369-p 449753 TQEQYELyCEMGSTF ubiquitination carcinogenesis, inhibited; signaling pathway regulation 36206490 8 10 81 inhibits FLT3 ubiquitination and degradation and hence FLT3 signaling +Gja1 GJA1 Channel, misc.; Membrane protein, integral; Membrane protein, multi-pass; Motility/polarity/chemotaxis P08050 24392 20q11 rat S373-p 459209 RASSRASsRPRPDDL activity, induced; protein degradation; molecular association, regulation; ubiquitination; intracellular localization ZO1(DISRUPTS); 14-3-3 theta(INDUCES); 14-3-3 zeta(INDUCES) 12417300; 17008717; 18163231; 25988944; 29021339 19 7 0 transport to the plasma membrane +MERTK Mer EC 2.7.10.1; KINASE; Kinase, protein; Membrane protein, integral; Oncoprotein; Protein kinase, TK; Protein kinase, tyrosine (receptor) Q12866 10461 2q13 human Y754-p 449990 KIYSGDYyRQGRIAK PK_Tyr_Ser-Thr enzymatic activity, induced 8702477 1 6 71 +ZAP70 ZAP70 EC 2.7.10.2; KINASE; Kinase, protein; Protein kinase, TK; Protein kinase, tyrosine (non-receptor) P43403 7535 2q11.2 human Y126-p 447589 RDAMVRDyVRQTWKL activity, induced; molecular association, regulation; intracellular localization; enzymatic activity, induced PKCT(INDUCES); CD3G(DISRUPTS) 27869819; 30992398 3 1 50 +NSD2 WHSC1 Amino Acid Metabolism - lysine degradation; EC 2.1.1.43; METHYLTRANSFERASE; Methyltransferase; Methyltransferase, protein lysine; Oncoprotein; Ubiquitin conjugating system O96028 7468 4p16.3 human K292-ub 12246197 EGEGQFEkLCQESAK PWWP protein degradation; ubiquitination cell differentiation, induced 32826945 1 2 17 BRCA1 increased polyubiquitination of WHSC1 during K562 cell cell differentiation +UHRF1 UHRF1 DNA-binding; EC 6.3.2.-; EC 6.3.2.19; Ligase; Transcription factor; UBIQUITIN LIGASE; Ubiquitin conjugating system; Ubiquitin ligase Q96T88 29128 19p13.3 human K644-ac 1883407603 FASPRTGkGKWKRKS cell cycle regulation; cell growth, induced 35951156 1 0 0 +MYO3A MYO3A Actin-binding; EC 2.7.11.1; KINASE; Kinase, protein; Motor; Protein kinase, STE; Protein kinase, Ser/Thr (non-receptor) Q8NEV4 53904 10p12.1 human T188-p 36841901 RRNTSVGtPFWMAPE Pkinase intracellular localization; enzymatic activity, induced 25402663 1 1 0 +Gfpt2 GFAT2 Amino Acid Metabolism - alanine, aspartate and glutamate; Carbohydrate Metabolism - amino sugar and nucleotide sugar; EC 2.6.1.16; Transferase Q9Z2Z9 14584 11 B1.2|11 29.9 cM mouse S202-p 451674 AVATRRGsPLLIGVR GATase_6 enzymatic activity, induced 15133036 1 8 0 +NFKB1 NFkB-p105 DNA-binding; Transcription factor P19838 4790 4q24 human K441-ub 5018601 TMDTESKkDPEGCDK molecular association, regulation; protein processing DNA(INDUCES) 10207090 1 0 0 +FGFR1 FGFR1 EC 2.7.10.1; KINASE; Kinase, protein; Membrane protein, integral; Oncoprotein; Protein kinase, TK; Protein kinase, tyrosine (receptor) P11362 2260 8p11.23 human S789-p 4703530 DTRSSTCsSGEDSVF ubiquitination; phosphorylation endocytosis, induced; signaling pathway regulation 24141780 1 2 0 inhibits tyrosine phosphorylation of FGFR1, regulates FGFR1 signaling +CDC25A CDC25A EC 3.1.3.48; Motility/polarity/chemotaxis; PHOSPHATASE; Protein phosphatase, dual-specificity P30304 993 3p21.31 human S513-p 26342100 RTWAGEKsKREMYSR protein degradation cell cycle regulation 21376736 1 1 0 proteasome mediated degradation +CAV1 caveolin-1 Adaptor/scaffold; Motility/polarity/chemotaxis; Nuclear receptor co-regulator Q03135 857 7q31.2 human K5-ub 22241810 ___MSGGkYVDSEGH molecular association, regulation; intracellular localization UBXN6(INDUCES); VCP(INDUCES) 23335559 1 7 0 CAV1 ubiquitylation and binding to the VCP-UBXD1 complex and sorting into lysosomes +GOT2 GOT2 Amino Acid Metabolism - alanine, aspartate and glutamate; Amino Acid Metabolism - arginine and proline; Amino Acid Metabolism - cysteine and methionine; Amino Acid Metabolism - phenylalanine; Amino Acid Metabolism - phenylalanine, tyrosine and tryptophan biosynthesis; Amino Acid Metabolism - tyrosine; EC 2.6.1.1; EC 2.6.1.7; Mitochondrial; Transferase P00505 2806 16q21 human K404-ac 461127 EFSIYMTkDGRISVA Aminotran_1_2 molecular association, regulation; phosphorylation carcinogenesis, induced; cell growth, induced; apoptosis, inhibited MDH2(INDUCES) 25755250 1 7 141 induces H3 phosphorylation +Samhd1 SAMHD1 EC 3.1.4.- Q60710 56045 2|2 H1 mouse T634-p 468674 DIIAPLItPLKWNNK enzymatic activity, inhibited; protein conformation 27920203 22 61 5 ablates its antiviral activity +Gorasp1 GRASP65 Vesicle O35254 56082 8q32 rat S277-p 455582 EQLPGPGsPGHGTAD activity, induced; acetylation; molecular association, regulation; intracellular localization cell cycle regulation; cytoskeletal reorganization; signaling pathway regulation 15834132; 18762583; 23259055; 25948586; 31336000 5 3 0 Regulation of mitotic golgi disassembly and reassembly; Golgi cisternae unstacking and orientation during motility; Golgi fragmentation; inactivation of T220/T224, and eventually S277partial dephosphorylation; inhibits acetylation and microtube stabilization, induce unlinking of Golgi complex and JNK/ERK signaling pathway regulation +GCSAM GCET2 Unknown function Q8N6F7 257144 3q13.2 human Y80-p 449472 QDNVDQTySEELCYT HGAL activity, induced signaling pathway regulation 31362927 1 1 66 regulates B cell receptor signaling +MAX MAX DNA-binding; Transcription factor P61244 4149 14q23.3 human K154-ac 474516 EEPQSRKkLRMEAS_ molecular association, regulation; intracellular localization transcription, induced B-Myc(INDUCES) DNA(DISRUPTS) 17217336 1 1 0 +TTK TTK Cancer Testis Antigen (CTA); EC 2.7.12.1; KINASE; Kinase, protein; Protein kinase, Other; Protein kinase, dual-specificity (non-receptor) P33981 7272 6q14.1 human Y811-p 459314 GTTEEMKyVLGQLVG protein stabilization; enzymatic activity, induced 18680479 1 2 29 +NOTCH1 Notch 1 Membrane protein, integral; Motility/polarity/chemotaxis; Oncoprotein; Receptor, misc.; Transcription factor P46531 4851 9q34.3 human S2516-p 35483202 FLTPSPEsPDQWSSS protein degradation; molecular association, regulation; ubiquitination carcinogenesis, inhibited FBXW7(INDUCES) 25344755 1 1 0 +NCK1 NCK1 Adaptor/scaffold; Motility/polarity/chemotaxis P16333 4690 3q22.3 human K178-ub 40190203 HVGSLSEkLAAVVNN protein degradation cytoskeletal reorganization 24287595 1 0 0 induces stress-fibre formation in synaptopodin-depleted podocytes, regulation of RhoA-mediated actin dynamics +Plk2 PLK2 EC 2.7.11.21; KINASE; Kinase, protein; Protein kinase, Other; Protein kinase, Ser/Thr (non-receptor); Tumor suppressor P53351 20620 13|13 D2.1 mouse T236-p 25790901 PLEHRRRtICGTPNY Pkinase enzymatic activity, induced cytoskeletal reorganization 12651910 2 0 1 The T236E constitutively active mutant, showed arborization and rounding. +Srebf1 SREBP-1 iso4 DNA-binding; Membrane protein, integral; Membrane protein, multi-pass; Transcription factor Q9WTN3-4 20787 11|11 B2 mouse S265-p 7996200 AIEKRYRsSINDKIV HLH molecular association, regulation transcription, altered DNA(DISRUPTS) 19244231 2 1 0 regulates hepatic lipogenesis +Tiam1 TIAM1 GEF; GEF, Rac/Rho; Motility/polarity/chemotaxis; Oncoprotein Q60610 21844 16 C3.3|16 51.5 cM mouse Y384-p 7362700 DRARQGVyENFRREL protein degradation; molecular association, regulation cell motility, altered; cytoskeletal reorganization GRB2(INDUCES); ERK2(INDUCES); ERK1(INDUCES) 19285946 1 2 7 Grb2-Sos1 +FOXC1 FOXC1 Cell cycle regulation; Cell development/differentiation; DNA-binding; Transcription factor Q12948 2296 6p25.3 human S272-p 460580 SSLSSGSsPPGSLPS activity, induced; molecular association, regulation; protein stabilization carcinogenesis, induced; cell motility, induced; transcription, induced DNA(INDUCES) 16492674; 31650548 2 2 0 ubiquitination and protein degradation inhibited. increased MMP10, SOX4 and SOX13 expression levels; activation of ERK1/2 is required for FOXC1 activation and stability +Mst1r Ron EC 2.7.10.1; KINASE; Kinase, protein; Membrane protein, integral; Protein kinase, TK; Protein kinase, tyrosine (receptor) Q62190 19882 9 59.07 cM|9 F1 mouse Y1330-p 456487 ASLLGDHyVQLTAAY enzymatic activity, induced apoptosis, induced; cell growth, altered GRB2(INDUCES); PLCG1(INDUCES); SHC1(INDUCES); PIK3CA(INDUCES) 16103119; 8918464 5 0 0 +TRIM32 TRIM32 EC 6.3.2.-; EC 6.3.2.19; Ligase; UBIQUITIN LIGASE; Ubiquitin conjugating system; Ubiquitin ligase Q13049 22954 9q33.1 human S651-p 27717300 SYHLRRYsTP_____ molecular association, regulation; ubiquitination; intracellular localization; protein conformation cell growth, induced 14-3-3 eta(INDUCES) 23444366 1 1 0 14-3-3 binding prevents both TRIM32 autoubiquitylation and TRIM32 transubiquitylation +SPTBN1 SPTBN1 Cytoskeletal; Motility/polarity/chemotaxis Q01082 6711 2p16.2 human T2159-p 471399 NGATEQRtSSKESSP molecular association, regulation SPTAN1(DISRUPTS) 17088250 1 20 1 increases in PC12 cells during neurite formation +Smad7 SMAD7 DNA-binding; Transcription factor O35253 17131 18|18 E3 mouse K64-ac 458989 RAGCCLGkAVRGAKG protein stabilization; ubiquitination apoptosis, induced 12408818; 17098745 2 2 0 inhibits ubiquitination further inducing protein stabilization; inhibits ubiquitination +UBE2J1 UBE2J1 EC 6.3.2.19; Membrane protein, integral; UBIQUITIN LIGASE; Ubiquitin conjugating system; Ubiquitin ligase Q9Y385 51465 6q15 human S184-p 465537 KELARQIsFKAEVNS protein degradation; enzymatic activity, induced cIAP1(INDUCES) 16720581; 28321712 3 13 52 ER stress cell recovery +Stxbp5 STXBP5 Vesicle Q9WU70 81022 1p13 rat S724-p 459032 GSSSPHNsDDEQKVN molecular association, regulation exocytosis, altered STX1B(DISRUPTS) 16186257 1 6 1 +Ccnd3 CCND3 Activator; Cell cycle regulation; Nuclear receptor co-regulator P30282 12445 17 C|17 23.37 cM mouse T283-p 452160 QGPSQTStPTDVTAI protein degradation; ubiquitination; intracellular localization cell cycle regulation; cell growth, inhibited; cell differentiation, induced; transcription, inhibited 17709384; 26008897 8 4 5 +MAP2K3 MKK3 EC 2.7.12.2; KINASE; Kinase, protein; Protein kinase, STE; Protein kinase, dual-specificity (non-receptor) P46734 5606 17p11.2 human T222-p 448277 LVDSVAKtMDAGCKP Pkinase activity, induced; enzymatic activity, induced cell cycle regulation; transcription, induced 17438131; 8622669; 9162092 6 2 2 +Tjp1 ZO1 Adaptor/scaffold; Motility/polarity/chemotaxis P39447 21872 7 C|7 35.02 cM mouse Y1177-p 450402 YRPEAQPySSTGPKS cell cycle regulation; cell motility, altered 18515860 0 5 36 +STAT3 STAT3 DNA-binding; Motility/polarity/chemotaxis; Nuclear receptor co-regulator; Transcription factor P40763 6774 17q21.2 human Y45-p 464379 IESQDWAyAASKESH STAT_int protein conformation transcription, induced 29531159 1 5 14 regulates dimerization +SIVA1 Siva Apoptosis O15304 10572 14q32.33 human Y34-p 448080 RGVCAERySQEVFEK Siva apoptosis, induced 11278261 1 0 0 +FOXM1 FOXM1 DNA-binding; Transcription factor Q08050 2305 12p13.33 human T620-p 3194573 SKSVLPRtPESWRLT protein stabilization cell cycle regulation; transcription, induced 22094256; 23240008 2 8 23 +RHBG RHBG Membrane protein, integral; Membrane protein, multi-pass; Transporter; Transporter, SLC family Q9H310 57127 1q22 human Y429-p 3647000 SPPDSQHyEDQVHWQ intracellular localization; activity, inhibited 18635543 1 0 0 +SKP2 SKP2 Cell cycle regulation; UBIQUITIN LIGASE; Ubiquitin conjugating system; Ubiquitin ligase Q13309 6502 5p13.2 human S256-p 1296362400 QTLLSSCsRLDELNL molecular association, regulation; ubiquitination; enzymatic activity, induced; phosphorylation carcinogenesis, induced; cell growth, induced; cell motility, induced; transcription, induced; signaling pathway regulation CUL1(INDUCES) 30413706; 33661942 3 1 0 +NFE2L1 NFE2L1 DNA-binding; Transcription factor Q14494 4779 17q21.32 human S379-p 27971902 SQDFLLFsPEVESLP protein degradation; ubiquitination apoptosis, induced 23623971 1 0 0 +Slc12a5 KCC2 Membrane protein, integral; Membrane protein, multi-pass; Transporter; Transporter, SLC family Q91V14 57138 2|2 H3 mouse S963-p 487533 ITDESRGsIRRKNPA SLC12 intracellular localization 34445881; 34752143 23 5 2 +G3BP1 G3BP-1 Adaptor/scaffold; EC 3.6.4.12; EC 3.6.4.13; Helicase; RNA-binding Q13283 10146 5q33.1 human R447-m1 476716 GGMRGPPrGGMVQKP translation, altered 27601476 1 6 72 inhibits Stress Granules (SGs)-RNA granule assembly upon environmental stress +EPAS1 HIF2A DNA-binding; Transcription factor Q99814 2034 2p21 human K685-ac 7761202 TFKTRSAkGFGARGP transcription, inhibited 19498162 2 1 0 +FLT3 FLT3 EC 2.7.10.1; KINASE; Kinase, protein; Membrane protein, integral; Oncoprotein; Protein kinase, TK; Protein kinase, tyrosine (receptor) P36888 2322 13q12.2 human Y768-p 459389 HSEDEIEyENQKRLE PK_Tyr_Ser-Thr molecular association, regulation cell cycle regulation GRB2(INDUCES) 19438505 2 0 0 regulates cell proliferation +PRKD1 PRKD1 Autophagy; EC 2.7.11.13; KINASE; Kinase, protein; Motility/polarity/chemotaxis; Protein kinase, CAMK; Protein kinase, Ser/Thr (non-receptor) Q15139 5587 14q12 human Y463-p 448648 NDTGSRYyKEIPLSE PH protein conformation; phosphorylation; enzymatic activity, induced cell differentiation, altered; apoptosis, inhibited; transcription, induced; transcription, altered; cell growth, altered 12505989; 12637538; 15024053; 16891660; 17804414 7 0 0 angiogenesis; leads to PLC-gamma phosphorylation; activates transciption; activates PKD and induces NF-kB and IKKB activation and degradation +BLM BLM DNA repair, damage; DNA replication; EC 3.6.4.12; Helicase P54132 641 15q26.1 human S502-p 34666301 HLQKSFVsSNWAETP BDHCT_assoc protein stabilization; molecular association, regulation; intracellular localization CUL3(DISRUPTS) 25015292 1 1 0 Chk1 prevents chromatin bridges and is required for BLM localization to anaphase bridges. +Oprm1 MOR-1 GPCR, family 1; Membrane protein, integral; Membrane protein, multi-pass; Receptor, GPCR P33535 25601 1q11 rat Y106-p 455804 MKTATNIyIFNLALA 7tm_1; TM activity, inhibited 11353794 2 0 0 +Eif4ebp1 4E-BP1 Translation; Translation initiation Q62622 116636 16q12.3 rat S82-p 447525 PTIPGVTsPTSDEPP eIF_4EBP molecular association, regulation translation, altered EIF4E(DISRUPTS) 10779345 7 9 0 +HSF1 HSF1 DNA-binding; Transcription factor Q00613 3297 8q24.3 human T369-p 469243 PSPPPTStPEKCLSV Vert_HS_TF transcription, inhibited 25963659 1 15 31 under non-stressed conditions, upon heat shock S to A mutant showed 60% higher luciferase activity +LALBA LALBA Apoptosis; Secreted; Secreted, signal peptide; Transferase P00711 281894 cow S66-p 1875112301 AIVQNNDsTEYGLFQ Lys molecular association, regulation; protein conformation IGE(DISRUPTS); IgG(DISRUPTS) 34655828 0 1 0 +TAGLN TAGLN Actin-binding; Motility/polarity/chemotaxis; Nuclear receptor co-regulator Q01995 6876 11q23.3 human S181-p 469978 VIGLQMGsNRGASQA Calponin molecular association, regulation cytoskeletal reorganization ACTB(DISRUPTS) 11053353; 17123483 3 15 14 +HAUS8 HAUS8 Cell cycle regulation Q9BT25 93323 19p13.11 human S151-p 20609209 EAMEMMEsQTLLLTL intracellular localization cell cycle regulation; apoptosis, inhibited 21690413 1 0 0 localization to the spindle +ELL ELL Nuclear receptor co-regulator; Oncoprotein; Transcription initiation complex P55199 8178 19p13.11 human K29-ac 1875199400 KVSVFHVkLTDSALR ELL protein degradation 32152128 1 0 0 +TARDBP TDP-43 RNA-binding Q13148 23435 1p36.22 human S369-p 6855907 EPNQAFGsGNNSYSG protein conformation 32778941 2 0 0 +Mecp2 MECP2 Transcription, coactivator/corepressor Q9Z2D6 17257 X A7.3|X 37.63 cM mouse Y120-p 37042901 SGRSAGKyDVYLINP MBD intracellular localization cell cycle regulation; cell motility, inhibited 25527496 2 0 0 localized to the centrosome, colocalized with gamma-tubuliin and pericentrin +RARA RARA DNA-binding; Nuclear receptor; Oncoprotein; Transcription factor P10276 5914 17q21.2 human S445-p 455329 APPPGSCsPSLSPSS protein degradation; ubiquitination signaling pathway regulation 15657432; 21272161 3 2 0 retinoid signaling +RGS18 RGS18 GAP; GAP, RGS Q9NS28 64407 1q31.2 human S218-p 4772688 NLRRRSRsFTCNEFQ molecular association, regulation signaling pathway regulation 14-3-3 gamma(INDUCES); 14-3-3 gamma(DISRUPTS) 22234696; 24244663 2 9 1 Ca 2+ signaling; followed by dephosphorylation of S49 and S218 +SENP2 SENP2 DESUMOYLASE; EC 3.4.22.68; Protease; Sumo-specific protease Q9HC62 59343 3q27.2 human T369-p 40499300 TDDLLELtEDMEKEI intracellular localization apoptosis, induced 25689261 3 1 0 nuclear export +ARHGDIB RhoGDI beta Cell adhesion; G protein regulator, misc.; Motility/polarity/chemotaxis P52566 397 12p12.3 human Y130-p 4113623 LKYVQHTyRTGVKVD Rho_GDI molecular association, regulation carcinogenesis, induced; cell motility, induced RHOA(DISRUPTS); SELPLG(INDUCES); RHOC(DISRUPTS) 24055812; 32903764 2 2 31 +Cry1 CRY1 DNA-binding; Lyase; Transcription, coactivator/corepressor P97784 12952 10 C1|10 41.63 cM mouse K585-ub 50596801 GTGLSSGkRPSQEED protein degradation; ubiquitination 26431207 1 0 0 +RPS3 RPS3 Apoptosis; EC 4.2.99.18; RNA-binding; Ribosomal; Translation P23396 6188 11q13.4 human R64-m2 9184301 NVLGEKGrRIRELTA KH_2 intracellular localization 19460357 1 0 0 regulates ribosome assembly +USF1 USF1 DNA-binding; Transcription factor P22415 7391 1q23.3 human S262-p 7367003 RQSNHRLsEELQGLD molecular association, regulation; acetylation 23219531 2 1 0 increases acetylation at USF1-K235 +GRK2 GRK2 EC 2.7.11.15; KINASE; Kinase, protein; Protein kinase, AGC; Protein kinase, Ser/Thr (non-receptor) P25098 156 11q13.2 human K19-ub 1872283501 SYLMAMEkSKATPAA protein degradation 17006543 1 0 0 +CCNE1 CCNE1 Activator; Cell cycle regulation; Nuclear receptor co-regulator P24864 898 19q12 human S387-p 454413 LSEQNRAsPLPSGLL protein degradation 14536078 2 17 1 +SALL4 SALL4 iso3 C2H2-type zinc finger protein; Cancer Testis Antigen (CTA); DNA-binding Q9UJQ4-2 57167 20q13.2 human K401-sm 31089513 RAPPTYVkVEVPGTF protein stabilization; molecular association, regulation; intracellular localization transcription, induced Oct4(DISRUPTS) 23012367 1 0 0 +SOX9 SOX9 DNA-binding; Transcription factor P48434 374148 chicken S64-p 451039 DPDLKKEsDEDKFPV Sox_N sumoylation signaling pathway regulation 23382206 6 0 0 induce NCC delamination +SHARPIN SHARPIN Apoptosis Q9H0F6 81858 8q24.3 human S131-p 31885533 QNGSKSNsPPALGPE molecular association, regulation ARP2(INDUCES) 36148554 1 2 0 +Rps6ka5 MSK1 EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, AGC; Protein kinase, Ser/Thr (non-receptor) Q8C050 73086 12|12 E mouse T645-p 448217 PDNQPLKtPCFTLHY Pkinase enzymatic activity, induced 17117922 16 1 0 +AATF AATF Nucleolus; RNA-binding; Transcription factor Q9NY61 26574 17q12 human S477-p 3753303 ELIERKTsSLDPNDQ TRAUB protein stabilization; molecular association, regulation apoptosis, inhibited; transcription, altered NFkB-p65(INDUCES) DNA(INDUCES) 17157788 1 0 0 +GAB2 GAB2 Adaptor/scaffold Q9UQC2 9846 11q14.1 human T391-p 448383 ATIPRRNtLPAMDNS molecular association, regulation; intracellular localization; activity, inhibited; phosphorylation cell growth, altered 14-3-3 beta(INDUCES); SHC1(DISRUPTS); GRB2(DISRUPTS); EGFR(DISRUPTS) 19172738 2 23 54 +Npm1 NPM1 Nucleolus; Oncoprotein; RNA-binding; Translation Q61937 18148 11|11 A4 mouse K27-ac 33347943 GCELKADkDYHFKVD Nucleoplasmin molecular association, regulation; intracellular localization MDM2(DISRUPTS) 33495326 1 4 2 Deacetylation of NPM1 at K27 and K54 leads to release of NPM from nucleoli and its association with HDM2. As a result HDM2-mediated proteasomal degradation of p53 is inhibited +CD84 CD84 Cell surface; Immunoglobulin superfamily; Membrane protein, integral; Motility/polarity/chemotaxis Q9UIB8 8832 1q23.3 human Y279-p 450870 AASKKTIyTYIMASR molecular association, regulation cell growth, altered SH2D1B(INDUCES); SH2D1A(INDUCES) 12928397 1 9 295 +Braf BRAF EC 2.7.11.1; KINASE; Kinase, protein; Oncoprotein; Protein kinase, Ser/Thr (non-receptor); Protein kinase, TKL F1M9C3 114486 4q22 rat S345-p 4273552 QFGQRDRsSSAPNVH phosphorylation 26333016 2 9 25 constitutively phosphorylated +KIF11 KIF11 Microtubule-binding; Motor P52732 3832 10q23.33 human T926-p 448410 LDIPTGTtPQRKSYL Microtub_bind molecular association, regulation; intracellular localization cell cycle regulation ERCC2(INDUCES) 21642957; 35977011; 8548803 8 29 2 helps in centrosome separation and normal progression through mitosis; regulates association with the spindle apparatus +USP7 USP7 DEUBIQUITINASE; EC 3.4.19.12; Protease; Ubiquitin conjugating system; Ubiquitin-specific protease Q93009 7874 16p13.2 human S18-p 449238 KAGEQQLsEPEDMEM protein stabilization; enzymatic activity, induced cell cycle regulation; DNA repair, inhibited; signaling pathway regulation 22361354; 28418900 2 63 5 inhibits ubiquitination and induces stability of itself and mdm2 and induces degradation of p53, regulates DNA damage signal transduction pathway +PKMYT1 Myt1 EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, Other; Protein kinase, Ser/Thr (non-receptor); Protein kinase, dual-specificity (non-receptor) Q99640 9088 16p13.3 human T412-p 11331001 QPLGPPAtPPGSPPC molecular association, regulation PIN1(INDUCES) 10504341 1 0 0 +RCHY1 RCHY1 EC 6.3.2.-; EC 6.3.2.19; Nuclear receptor co-regulator; UBIQUITIN LIGASE; Ubiquitin conjugating system; Ubiquitin ligase Q96PM5 25898 4q21.1 human S155-p 483982 CLEDIHTsRVVAHVL zf-RING_2 ubiquitination; intracellular localization; enzymatic activity, inhibited cell growth, altered p53(DISRUPTS) 17568776 1 1 0 cytoplasmic localization +Mbp MBP iso5 Cytoskeletal P04370-5 17196 18 E3|18 55.84 cM mouse T96-p 450929 KNIVTPRtPPPSQGK Myelin_MBP protein stabilization; molecular association, regulation; intracellular localization cytoskeletal reorganization Fyn(DISRUPTS) 21887699; 23861868 14 14 7 +Glul GLUL Amino Acid Metabolism - alanine, aspartate and glutamate; Amino Acid Metabolism - arginine and proline; EC 4.1.1.15; EC 6.3.1.2; Energy Metabolism - nitrogen; Ligase P15105 14645 1|1 G3 mouse T301-p 15501403 LDNARRLtGFHETSN enzymatic activity, inhibited 31178690 1 3 2 +Bad BAD Apoptosis O35147 64639 1q43 rat S129-p 447861 EGMEEELsPFRGRSR Bcl-2_BAD molecular association, regulation apoptosis, induced 14-3-3 zeta(DISRUPTS) 12049737 7 10 36 +USP25 USP25 DEUBIQUITINASE; EC 3.4.19.12; Protease; Ubiquitin conjugating system; Ubiquitin-specific protease Q9UHP3 29761 21q21.1 human K99-sm 3084637 IDLTGDDkDDLQRAI UIM ubiquitination; enzymatic activity, inhibited 18538659 1 1 0 sumoylation inhibits ubiquitin chain hydrolysis and has reduced afinity to ubiquitin chains +NPAT NPAT Cell cycle regulation; Transcription regulation Q14207 4863 11q22.3 human T1350-p 2286401 ISRTTSAtPLKDNTQ NPAT_C transcription, induced 10995387 1 4 5 multiple sites deletion mutant +GABRB3 GABRB3 Channel, chloride; Channel, ligand-gated; Membrane protein, integral; Membrane protein, multi-pass; Transporter; Transporter, ion channel P28472 2562 15q12 human S432-p 450245 KTHLRRRsSQLKIKI Neur_chan_memb receptor internalization, inhibited apoptosis, inhibited 24513087 12 0 0 +XRCC3 XRCC3 DNA repair, damage O43542 7517 14q32.33 human S225-p 482710 PFRCEFDsQASAPRA Rad51 activity, induced cell cycle regulation; DNA repair, induced; signaling pathway regulation 23438602 1 1 0 XRCC3 phosphorylation is important for cellular resistance; ATR/ATM pathway +ACP1 ACP1 Cofactor and Vitamin Metabolism - riboflavin; EC 3.1.3.2; EC 3.1.3.48; Motility/polarity/chemotaxis; PHOSPHATASE; Phosphatase (non-protein); Protein phosphatase, tyrosine (non-receptor) P24666 52 2p25.3 human Y133-p 457445 LIIEDPYyGNDSDFE LMWPc molecular association, regulation; phosphorylation; enzymatic activity, induced cell motility, altered; cell adhesion, altered; cell growth, altered GRB2(INDUCES) 10671492; 10980198; 16890200; 9038134 5 6 81 +YTHDF2 YTHDF2 RNA processing; RNA-binding Q9Y5A9 51441 1p35.3 human T381-p 6223825 SQAGSGStPSEPHPV protein stabilization carcinogenesis, induced; cell growth, induced; apoptosis, inhibited; RNA stability, inhibited 33420027 1 0 3 +Mapt Tau ACETYLTRANSFERASE; Acetyltransferase; Cytoskeletal P10637 17762 11 67.79 cM|11 E1 mouse K572-ac 25223700 GKVQIINkKLDLSNV Tubulin-binding acetylation; phosphorylation 33910013 13 2 0 required for acetylation and phosphorylation +RELA NFkB-p65 DNA-binding; Nuclear receptor co-regulator; Transcription factor Q04206 5970 11q13.1 human K37-me 31094535 RGMRFRYkCEGRSAG RHD_DNA_bind transcription, induced 23904479 2 0 0 differential regulation of gene expression +KIF20A KIF20A Microtubule-binding; Motor O95235 10112 5q31.2 human S21-p 4921068 SDDDVVVsPMFESTA molecular association, regulation; intracellular localization; protein conformation cell cycle regulation INCENP(DISRUPTS) 24656812 1 4 0 favours solubility, inhibits microtubule binding +PARP1 PARP1 DNA repair, damage; EC 2.4.2.30; Nuclear envelope; Nuclear receptor co-regulator; Nucleolus; Transferase P09874 142 1q42.12 human K949-ub 12324641 PKGKHSVkGLGKTTP PARP protein degradation 31616951 1 2 7 +Eif3f eIF3-epsilon EC 3.4.19.12; Translation; Translation initiation Q9DCH4 66085 7|7 E3 mouse K258-ub 7388006 IGVDLIMkTCFSPNR MitMem_reg protein degradation 19073596 1 0 0 regulates skeletal muscle atrophy +PDIK1L CLIK1L EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, Other; Protein kinase, Ser/Thr (non-receptor) Q8N165 149420 1p36.11 human S194-p 56663329 KVADFGLsKVCSASG Pkinase enzymatic activity, induced carcinogenesis, inhibited; cell growth, inhibited 35021089 1 1 0 +Gjd2 GJD2 Cell adhesion; Channel, misc.; Membrane protein, integral; Membrane protein, multi-pass O54851 14617 2|2 E4 mouse S110-p 471386 KQRERRYsTVFLALD Connexin activity, inhibited neural plasticity 16956882 1 2 2 adaptation to ambient light conditions; regulating gap junction communication +SAFB SAFB1 DNA-binding; Nuclear receptor co-regulator; RNA-binding Q15424 6294 19p13.3 human K231-sm 15511917 TCKSEPVkEESSELE molecular association, regulation transcription, inhibited HDAC3(INDUCES) 21527249 1 4 0 +HTT Huntingtin Cytoskeletal P42858 3064 4p16.3 human K9-ub 1877148901 ATLEKLMkAFESLKS ubiquitination 32675242 1 0 0 K6 and K9 sites were ubquitinated in WT were mutated to R and slowed aggregation and reduce size, but increase in smaller size aggregates but increased death rates. +Nfkb2 NFkB-p100 DNA-binding; Oncoprotein; Transcription factor Q5U2Z4 309452 1q54 rat S868-p 450167 KEDSAYGsQSVEQEA apoptosis, inhibited 21550382 7 1 1 induces cell survival +NEDD1 NEDD1 Cell cycle regulation Q8NHV4 121441 12q23.1 human S397-p 4272994 GKNQDFSsFDDTGKS molecular association, regulation cell cycle regulation 19509060 2 14 1 important for binding of NEDD1 with gamma-tubulin +Cebpb C/EBP-beta DNA-binding; Motility/polarity/chemotaxis; Transcription factor P21272 24253 3q42 rat S273-p 13373502 QKKVEQLsRELSTLR bZIP_2 molecular association, regulation cell cycle regulation; transcription, induced C/EBP-beta(INDUCES) DNA(INDUCES) 20351173 1 1 1 +GATA3 GATA3 Transcription factor P23771 2625 10p14 human S308-p 456464 IKPKRRLsAARRAGT activity, induced; protein degradation cell growth, induced; transcription, induced DNA(INDUCES) 16109788; 25479686; 28498822 4 0 0 +EMSY EMSY DNA repair, damage; Transcription regulation Q7Z589 56946 11q13.5 human S209-p 453526 RKRRRTNsSSSSPVV transcription, induced 22315412 3 38 194 IFN-stimulated genes induced, including mammary and ovarian carcinoma cell lines, inhibits viral replication +Camk2a CAMK2A EC 2.7.11.17; KINASE; Kinase, protein; Protein kinase, CAMK; Protein kinase, Ser/Thr (non-receptor) P11798 12322 18 E1|18 34.41 cM mouse T306-p 449596 LKGAILTtMLATRNF molecular association, regulation; enzymatic activity, inhibited; intracellular localization; phosphorylation neural plasticity NMDAR2B(DISRUPTS); Calmodulin(DISRUPTS) 12408851; 28636948; 33853773 18 10 2 regulates phosphorylation at T286 and of GluA1 at S831; inhibits phosphorylation at T286, regulates LTP, fear memory, spatial learning +YAP1 YAP1 Oncoprotein; Transcription, coactivator/corepressor P46937 10413 11q22.1 human K280-ub 964556212 ISQSAPVkQPPPLAP protein degradation carcinogenesis, altered; carcinogenesis, inhibited; cell growth, inhibited 31393050; 36271031 2 2 0 +SUPT5H SPT5 RNA-binding; Transcription, coactivator/corepressor O00267 6829 19q13.2 human R698-m2 475966 SGGMSRGrGRRDNEL transcription, inhibited 12718890 1 0 0 inhibition of in vitro transcription assays and HIV-1 gene expression +Brsk2 BRSK2 EC 2.7.11.1; EC 2.7.11.26; KINASE; Kinase, protein; Protein kinase, CAMK; Protein kinase, Ser/Thr (non-receptor) Q69Z98 75770 7|7 F5 mouse S436-p 4734879 PRVTPHPsPRGSPLP protein stabilization; enzymatic activity, inhibited; phosphorylation 23790753 1 8 0 inhibits axon branching (activated in BRSK2 18A mutant) +S100A4 S100A4 Calcium-binding; Cell development/differentiation P26447 6275 1q21.3 human K96-sm 25352006 FFEGFPDkQPRKK__ intracellular localization transcription, induced 20685652 1 0 0 +CLCN2 CLCN2 Channel, chloride; Membrane protein, integral; Membrane protein, multi-pass; Transporter; Transporter, ion channel P51788 1181 3q27.1 human S76-p 2902201 CARCRVCsVRCHKFL activity, induced 15358127 1 0 0 +PEA15 PEA-15 Apoptosis; Motility/polarity/chemotaxis Q15121 8682 1q23.2 human S116-p 450281 KDIIRQPsEEEIIKL molecular association, regulation; protein stabilization; intracellular localization; protein conformation carcinogenesis, induced; autophagy, induced; cell motility, induced; apoptosis, inhibited; transcription, induced; autophagy, altered; signaling pathway regulation FADD(INDUCES) 12808093; 17227770; 17700518; 20452983; 21285289; 25416196; 30569123; 33574916; 34241740; 34615962; 34997083 15 95 1092 +SF1 SF1 RNA splicing; RNA-binding; Spliceosome; Transcription, coactivator/corepressor Q15637 7536 11q13.1 human S20-p 449919 PSKKRKRsRWNQDTM SF1-HH protein conformation RNA splicing, altered U2AF1(DISRUPTS) 12718882 2 3 0 The structure of the complex suggests that a combination of steric interference and unfavorable electrostatic contacts of the phosphorylated S20 with the negatively charged helix A in U2AF-RMM3/SF1. +Gata1 GATA1 DNA-binding; Transcription factor P17679 14460 X A1.1|X 3.59 cM mouse S310-p 451231 QTRNRKAsGKGKKKR protein degradation; acetylation; ubiquitination; phosphorylation cell differentiation, altered; transcription, induced DNA(INDUCES) 16204311; 16858405 10 0 0 Phosphorylation and acetylation cause the degradation of acetylated GATA-1; S310A acts like a dominant negative mutation on EpoR-induced differentiation.; DNA binding is required for MAPK-dependent phosphorylation +ERG ERG DNA-binding; Oncoprotein; Transcription factor P11308 2078 21q22.2 human S215-p 9429097 VDKALQNsPRLMHAR protein conformation cell motility, induced; transcription, induced 23918819; 25885538; 28887309 3 13 2 S215 and the FXFP motif required to promote prostate cell migration and activate target genes +GRIK2 GluR6 Channel, calcium; Channel, ligand-gated; Membrane protein, integral; Membrane protein, multi-pass Q13002 2898 6q16.3 human S846-p 11496000 VGEFLYKsKKNAQLE sumoylation; intracellular localization; phosphorylation; palmitoylation endocytosis, altered 37868810 5 0 0 palmitoylation maintains surface expression and regulates agonist -induced internalisation +ICAM3 ICAM3 Cell adhesion; Immunoglobulin superfamily; Membrane protein, integral P32942 3385 19p13.2 human S525-p 451213 SYHVREEsTYLPLTS molecular association, regulation; intracellular localization NHERF(NOT_REPORTED) 11784723 1 1 14 +PGR PR DNA-binding; Nuclear receptor; Transcription factor P06401 5241 11q22.1 human S81-p 450160 TQDQQSLsDVEGAYS Prog_receptor molecular association, regulation carcinogenesis, induced; cell growth, induced; transcription, induced DNA(INDUCES) 21518957; 23921636; 8662865 5 3 0 +PLAG1 PLAG1 C2H2-type zinc finger protein; DNA-binding; Oncoprotein; Transcription factor Q6DJT9 5324 8q12.1 human K263-sm 3568001 CNVSVPIkDELLPVM intracellular localization cell growth, induced; transcription, inhibited 15208321; 16207715 2 0 0 +Arrb2 ARRB2 Adaptor/scaffold P29067 25388 10q24 rat S14-p 23083983 TRVFKKSsPNCKLTV activity, induced; molecular association, regulation; protein conformation ADRB2(INDUCES); GRK2(INDUCES) 31948726 2 1 1 induces pre-active state +DOK1 DOK1 Adaptor/scaffold; Motility/polarity/chemotaxis Q99704 1796 2p13.1 human S443-p 454883 ATGSGIKsHNSALYS cell motility, induced; cell growth, inhibited 15574499 1 0 0 +NFKBIB IkB-beta Inhibitor Q15653 4793 19q13.2 human S315-p 452014 SGPCSSSsDSDSGDE activity, induced; intracellular localization transcription, inhibited; transcription, altered CCDC32(INDUCES) 12732617; 8887627; 9278383 3 0 0 Phosphorylation blocks NF-kB-directed transcription.; and in vivo, NFkB/Rel activation +KRAS KRas G protein; G protein, monomeric; G protein, monomeric, Ras; Motility/polarity/chemotaxis; Oncoprotein P01116 3845 12p12.1 human K104-ac 35480405 REQIKRVkDSEDVPM Ras molecular association, regulation; intracellular localization; enzymatic activity, inhibited; protein conformation carcinogenesis, inhibited; cell growth, inhibited; cell motility, inhibited RAF1(DISRUPTS) 22711838; 23723075; 30792310; 33060649 6 3 0 hampered GEF binding, inhibition of NPIPA2, DUSP1 and IL6 expression in lung and ovarian cancer cells, reduced invasion +SNPH syntaphilin iso2 Membrane protein, integral; Vesicle O15079-2 9751 20p13 human T63-p 23150253 SAGSRRRtSPPVSVR Syntaphilin cell growth, induced 34087103 1 1 2 +MAPT Tau iso8 ACETYLTRANSFERASE; Acetyltransferase; Cytoskeletal P10636-8 4137 17q21.31 human S305-p 487457 KHVPGGGsVQIVYKP Tubulin-binding molecular association, regulation 21204788 4 4 0 in vitro microtubule binding +ARHGEF4 ARHGEF4 iso3 GEF; GEF, Rac/Rho; Motility/polarity/chemotaxis Q9NR80-3 50649 2q21.1 human Y94-p 3333400 VGSEEDLyDDLHSSS activity, induced 18653540 1 0 0 important for EGF-induced activation of Rac1 and Cdc42 +Myog myogenin DNA-binding; Transcription factor P12979 17928 1 E4|1 58.18 cM mouse S43-p 1880114100 ERTELSLsPEARGPL protein degradation; molecular association, regulation; ubiquitination transcription, inhibited FBXO32(INDUCES) 36259412 1 0 0 +Ubb UBB Apoptosis; Cell cycle regulation; Cell development/differentiation; Motility/polarity/chemotaxis; Transcription regulation; Ubiquitin-like modifier P0CG49 22187 11 B2|11 38.46 cM mouse K63-ub 19008158 LSDYNIQkESTLHLV ubiquitin molecular association, regulation DNA repair, induced; chromatin organization, altered BRCA1(INDUCES); 53BP1(INDUCES) 25578731 1 14 108 +METTL14 METTL14 EC 2.1.1.62; METHYLTRANSFERASE; Methyltransferase Q9HCE5 57721 4q26 human S399-p 15427105 IERLRPKsPPPKSKS molecular association, regulation METTL3(INDUCES) 27281194 1 14 7 +CEP76 CEP76 Q8TAP6 79959 18p11.21 human S83-p 2048409 VEQELPSsPKQPICF cell cycle regulation 27065328 1 23 3 suppresses centriole ampli?cation in S phase +IKBKG IKKG Adaptor/scaffold; Protein kinase, regulatory subunit Q9Y6K9 8517 Xq28 human Y374-p 473650 PLPPAPAyLSSPLAL enzymatic activity, inhibited; phosphorylation signaling pathway regulation 23131831 1 0 13 modulates IFKB phosphorylation; regulation of TCR mediated calcium (Ca2+) influx; NF-kB pathway +Cbl CBL Adaptor/scaffold; EC 6.3.2.-; EC 6.3.2.19; Ligase; Motility/polarity/chemotaxis; Oncoprotein; UBIQUITIN LIGASE; Ubiquitin conjugating system; Ubiquitin ligase P22682 12402 9 A5.1-A5.2|9 24.72 cM mouse Y780-p 448531 SENEDDGyDVPKPPV molecular association, regulation cytoskeletal reorganization Src(INDUCES) 34019873 16 4 257 +Notch1 Notch 1 Membrane protein, integral; Motility/polarity/chemotaxis; Oncoprotein; Receptor, misc.; Transcription factor Q01705 18128 2 A3|2 18.91 cM mouse K2164-ac 18899510 ACGSKEAkDLKARRK protein stabilization; ubiquitination 21499261 2 1 0 +NUMA1 NuMA-1 Cell cycle regulation; Motility/polarity/chemotaxis Q14980 4926 11q13.4 human T2055-p 472502 MAFSILNtPKKLGNS cytoskeletal reorganization 23921553 4 28 16 cortical NuMA/dynein localization, proper metaphase spindle positioning +Myo3b MYO3B Actin-binding; EC 2.7.11.1; KINASE; Kinase, protein; Motor; Protein kinase, STE; Protein kinase, Ser/Thr (non-receptor) Q1EG27 329421 2|2 C2 mouse T178-p 36841906 STRLRRNtSVGTPFW Pkinase enzymatic activity, induced 21895655 1 1 0 +HSP90AA1 HSP90A Chaperone; Heat shock protein P07900 3320 14q32.31 human K558-ac 2884405 LPEDEEEkKKQEEKK HSP90 molecular association, regulation carcinogenesis, induced; exocytosis, induced CHIP(DISRUPTS); TEBP(DISRUPTS); HSP70(DISRUPTS); MMP2(INDUCES); HSP40(DISRUPTS) 18559531 1 4 1 +AIMP2 JTV1 Translation; Translation regulation Q13155 7965 7p22.1 human S156-p 55571504 LSTVHTHsSVKSVPE Thioredoxin_16 molecular association, regulation; intracellular localization cell growth, inhibited EPRS(DISRUPTS) 27197155 1 0 0 nuclear localization; reduced association with MSC +P2RY2 P2Y2 GPCR, family 1; Membrane protein, integral; Membrane protein, multi-pass; Receptor, GPCR; Receptor, misc. P41231 5029 11q13.4 human T344-p 2909201 GLRRSDRtDMQRIED receptor desensitization, altered; intracellular localization 16311903 2 0 0 +Srsf5 SFRS5 RNA processing; RNA-binding; Spliceosome Q09167 29667 6q24 rat S86-p 3685800 GRGRGRYsDRFSSRR RNA splicing, altered 15684423 2 5 0 +YWHAQ 14-3-3 theta Adaptor/scaffold P27348 10971 2p25.1 human S232-p 456053 LTLWTSDsAGEECDA protein conformation apoptosis, induced 25862939 4 16 0 cell survival inhibited, BAX oligomerization induced +BTG1 BTG1 Cell cycle regulation; Oncoprotein P62324 694 12q21.33 human S159-p 457381 ELLLGRTsPSKNYNM molecular association, regulation cell growth, altered CAF-1A(INDUCES) 9820826 1 5 2 +Pebp1 RKIP Lipid-binding; Protein kinase, regulatory subunit P31044 29542 12q16 rat S51-p 3189670 TQVMNRPsSISWDGL PBP enzymatic activity, inhibited; phosphorylation; enzymatic activity, induced signaling pathway regulation 35696587 1 11 8 regulates ?-AR signaling through inhibition of GRK2 activity,; primes phosphorylation at S153 further enhancing PKA activity +EP300 p300 ACETYLTRANSFERASE; Acetyltransferase; EC 2.3.1.48; Motility/polarity/chemotaxis; Nuclear receptor co-regulator; Transcription, coactivator/corepressor Q09472 2033 22q13.2 human S12-p 25126714 VVEPGPPsAKRPKLS acetylation; molecular association, regulation; enzymatic activity, induced cell differentiation, induced; transcription, induced; signaling pathway regulation CTNNB1(INDUCES) 22465714; 33355181 2 6 0 C/EBP-beta acetylation induced, induces cancer-associated muscle wasting; Wnt/Beta- catenin signaling pathway +TOP1 TOP1 EC 5.99.1.2; Isomerase; Nucleolus; Oncoprotein P11387 7150 20q12 human S21-p 2721301 ADFRLNDsHKHKDKH enzymatic activity, induced 18408216 1 4 0 enhances DNA relaxation activity in vitro +TIMP2 TIMP2 Cell development/differentiation; Extracellular matrix; Inhibitor; Motility/polarity/chemotaxis; Secreted; Secreted, signal peptide P16035 7077 17q25.3 human Y90-p 1257779601 EKDIEFIyTAPSSAV TIMP molecular association, regulation MMP2(INDUCES) 30227959 1 0 0 +HECTD3 HECTD3 EC 6.3.2.-; EC 6.3.2.19; Ligase; UBIQUITIN LIGASE; Ubiquitin conjugating system; Ubiquitin ligase Q5T447 79654 1p34.1 human S192-p 150180311 TYSHRLGsRPQPAEA molecular association, regulation apoptosis, inhibited CASP9(INDUCES) 28716524 1 1 0 +Lat2 LAB Adaptor/scaffold; Membrane protein, integral Q9JHL0 56743 5|5 G2 mouse Y139-p 450963 EDDDSNSyENVLVCK LAT2 signaling pathway regulation 22308309 3 10 169 plays a negative role in TCR and FcRI-mediated and no role in LPS-mediated signaling +Camk2b CAMK2B EC 2.7.11.17; KINASE; Kinase, protein; Protein kinase, CAMK; Protein kinase, Ser/Thr (non-receptor) P08413 24245 14q21 rat S327-p 48915806 TTAPATMsTAASGTT molecular association, regulation 26291163 1 1 0 inhibits interaction with F-actin, regulates synaptic plasticity +Nfkbib IkB-beta Inhibitor Q60778 18036 7|7 B1 mouse S23-p 447916 WCDSGLGsLGPDAAA protein degradation 10497169; 9092533 6 0 0 +TRIM28 TIF1B EC 6.3.2.-; KINASE; Kinase, protein; Ligase; Nuclear receptor co-regulator; Protein kinase, atypical; SUMO LIGASE; SUMO ligase; Transcription, coactivator/corepressor; UBIQUITIN LIGASE; Ubiquitin conjugating system; Ubiquitin ligase Q13263 10155 19q13.43 human K750-sm 3142606 IRARLQEkLSPPYSS transcription, inhibited 31391303 2 8 0 loss of TF1B sumoylation induces dsRNA-activated IFN-mediated defenses that rely on RIG-I, MAVS, TBK1, and JAK1 transcription, SUMOylated TIF1B Is required to support efficient virus replication +Plcb3 PLCB3 Carbohydrate Metabolism - inositol phosphate; EC 3.1.4.11; Phospholipase Q99JE6 29322 1q43 rat S1105-p 448448 LDRKRNNsISEAKTR PLC-beta_C intracellular localization; enzymatic activity, inhibited 11278298; 15998840 5 22 216 +Ppp1r1b DARPP-32 Motility/polarity/chemotaxis; Protein phosphatase, regulatory subunit Q6J4I0 360616 10q31 rat S45-p 465607 LFRVSEHsSPEEESS DARPP-32 protein conformation 8226946 2 7 4 PKA phosphorylation did not alter fluorescence parameters, and only minor effects were associated with casein kinase II +PXN PXN iso2 Adaptor/scaffold; Cell adhesion; Cytoskeletal; Motility/polarity/chemotaxis P49023-2 5829 12q24.23 human S83-p 451113 FIHQQPQsSSPVYGS Paxillin cell cycle regulation; carcinogenesis, altered; transcription, altered 20628053 7 40 44 regulates Erk1/2-induced cell proliferation and transcription +Rptor Raptor Adaptor/scaffold Q8K4Q0 74370 11|11 E2 mouse S696-p 11315003 EKNYPLPsPAATEGG molecular association, regulation signaling pathway regulation PRAS40(INDUCES); p70S6K(INDUCES) 24239769 8 11 1 mechanical stress-induced mTOR signaling +ASIC1 ASIC1 iso1 Channel, cation; Membrane protein, integral; Membrane protein, multi-pass; Transporter; Transporter, ion channel P78348-1 41 12q13.12 human S525-p 449558 QKEAKRSsADKGVAL molecular association, regulation PICK1(DISRUPTS) 12578970 2 0 0 +REL REL Oncoprotein; Transcription factor Q04864 5966 2p16.1 human S526-p 1980800 LENPSCNsVLDPRDL activity, induced transcription, induced 16585559 1 0 0 Double mutant S491A S494 is not responsive to NIK-induced activation of transcription at the IL-2 promoter. The comparable site to S494 in mouse Rel is an alanine, so S491 may be the more important residue. +RPS6KA1 p90RSK EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, AGC; Protein kinase, Ser/Thr (non-receptor); Translation Q15418 6195 1p36.11 human T573-p 447993 AENGLLMtPCYTANF Pkinase molecular association, regulation; protein conformation; enzymatic activity, induced signaling pathway regulation GSK3B(INDUCES); p90RSK(INDUCES) 12917346; 25730857; 28574827; 37059179 20 16 180 morphine-inhibited insulin receptor signaling +DRD2 DRD2 GPCR, family 1; Membrane protein, integral; Membrane protein, multi-pass; Receptor, GPCR P14416 1813 11q23.2 human K241-ub 4793400 AHLRAPLkGNCTHPE 7tm_1 protein degradation 32572597 2 0 0 +CACB CACNA1C Channel, calcium; Membrane protein, integral; Membrane protein, multi-pass P15381 100101555 rabbit T1704-p 17620920 RAISGDLtAEEELDK CAC1F_C activity, induced 20876873; 28295363; 36215501 9 1 0 induces CaV1.2 activity +SLC4A4 SLC4A4 Membrane protein, integral; Membrane protein, multi-pass; Transporter; Transporter, SLC family Q9Y6R1 8671 4q13.3 human S233-p 4699760 DIGKTVSsASRMFTN Band_3_cyto protein conformation; activity, inhibited 30377224 1 6 3 +Rrad RRAD G protein; G protein, monomeric; G protein, monomeric, RGK O88667 56437 8|8 D3 mouse S299-p 457398 KMAFRAKsKSCHDLS molecular association, regulation; intracellular localization 14-3-3 beta(DISRUPTS) 17605760 2 2 0 +TCOF1 treacle Nucleolus; RNA-binding; Transcription, coactivator/corepressor Q13428 6949 5q32-q33.1 human S1199-p 20622158 EDDVVAPsQSLLSGY molecular association, regulation; intracellular localization NBS1(INDUCES) 25512513 1 3 0 nucleolar localization +SIK1 SIK EC 2.7.11.1; KINASE; Kinase, protein; Motility/polarity/chemotaxis; Protein kinase, CAMK; Protein kinase, Ser/Thr (non-receptor); Tumor suppressor P57059 150094 21q22.3 human S435-p 7445611 VFRPRPVsPSSLLDT protein degradation; molecular association, regulation; ubiquitination; intracellular localization; enzymatic activity, inhibited; phosphorylation carcinogenesis, induced; apoptosis, altered; cell growth, induced; transcription, induced; signaling pathway regulation 14-3-3 zeta(INDUCES); 14-3-3 epsilon(INDUCES); 14-3-3 eta(INDUCES); PIN1(INDUCES); 14-3-3 beta(INDUCES); 14-3-3 theta(INDUCES); 14-3-3 gamma(INDUCES); ITCH(INDUCES) 36806887 2 11 4 +BLM BLM DNA repair, damage; DNA replication; EC 3.6.4.12; Helicase P54132 641 15q26.1 human S304-p 467231 DTDFVPPsPEEIISA BLM_N molecular association, regulation TOPBP1(INDUCES) 25794620 2 4 2 genome stability- suppression of sister chromatid exchanges +SLC40A1 SLC40A1 Membrane protein, integral; Membrane protein, multi-pass; Transporter; Transporter, SLC family Q9NP59 30061 2q32.2 human K240-sm 1881493600 LAVKAGLkEEETELK sumoylation; ubiquitination; intracellular localization 33490642 1 0 0 Sumoylation of K240E mutation impedes Fpn trafficking and is diffused throughout the cytoplasm, and affects iron homeostasis. +Pparg PPAR-gamma DNA-binding; Nuclear receptor; Transcription factor P37238 19016 6 E3|6 53.41 cM mouse K395-sm 12004433 FGDFMEPkFEFAVKF Hormone_recep activity, inhibited cell differentiation, inhibited 34249943 8 0 0 SENP3 desumoylated PPAR-gamma and enhanced its activity to promote-the expression of adipogenic marker genes such as C/EBPa, adiponectin and FABP4 +MCU MCU Membrane protein, integral; Membrane protein, multi-pass; Mitochondrial Q8NE86 90550 10q22.1 human K332-ac 466738 AQAEMDLkRLRDPLQ apoptosis, induced 35636016 1 3 42 increase of mitochondrial Ca2+ iflux and the loss of mitochondrial membrane potential (MMP), INZ treatment significantly induced cell apoptosis in tumor tissues +HSPB8 HSPB8 Heat shock protein Q9UJY1 26353 12q24.23 human S24-p 2201402 RRDPFRDsPLSSRLL protein conformation 21526341 2 16 0 decrease chaperone activity +PLK1 PLK1 EC 2.7.11.21; KINASE; Kinase, protein; Protein kinase, Other; Protein kinase, Ser/Thr (non-receptor) P53350 5347 16p12.2 human S99-p 63280100 PHQREKMsMEISIHR Pkinase cell cycle regulation 28351953 1 0 0 mitotic acceleration +KLRC1 NKG2A Membrane protein, integral; Receptor, misc. P26715 3821 12p13.2 human Y8-p 455555 MDNQGVIySDLNLPP molecular association, regulation; intracellular localization SHP-1(INDUCES) 12165520 1 0 0 +RARA RARA DNA-binding; Nuclear receptor; Oncoprotein; Transcription factor P10276 5914 17q21.2 human S461-p 455330 RSSPATHsP______ protein degradation; ubiquitination signaling pathway regulation 15657432; 21272161 3 0 0 retinoid signaling +SEPTIN12 SEPT12 Cell cycle regulation; Cytoskeletal; Hydrolase Q8IYM1 124404 16p13.3 human S198-p 63250400 PVIARADsLTMEERE Septin molecular association, regulation; protein conformation SEPT7(DISRUPTS) 28346465 1 1 0 loss of the sperm annulus/septin ring and poor male fertility +TNIP1 TNIP1 Transcription regulation Q15025 10318 5q33.1 human S123-p 1880462802 PPSSGTSsEFEVVTP protein degradation; molecular association, regulation; ubiquitination autophagy, induced; transcription, induced LC3B(INDUCES); LC3C(INDUCES); GABARAPL2(INDUCES) 36574265 1 1 0 +XRCC4 XRCC4 DNA repair, damage Q13426 7518 5q14.2 human S327-p 3195416 SLETLRNsSPEDLFD XRCC4 ubiquitination; intracellular localization DNA repair, induced DNA(INDUCES) 26774286 2 11 1 recruitment to DNA damage sites +Tnp2 TP2 DNA-binding P11101 24840 10q11 rat K93-ac 10769111 EGKVSKRkAVRRRKR TP2 molecular association, regulation chromatin organization, altered NPM3(DISRUPTS) 19710011 1 1 0 +Nphs1 NPHS1 Cell adhesion; Immunoglobulin superfamily; Membrane protein, integral Q9QZS7 54631 7|7 B1 mouse S1160-p 1876873800 YYSMRDFsPQLPPTL molecular association, regulation endocytosis, induced PICK1(INDUCES); PKCA(INDUCES) 35451598 1 0 0 +Yy1 YY1 C2H2-type zinc finger protein; Cell development/differentiation; Transcription factor Q00899 22632 12 F1|12 59.58 cM mouse K392-ac 1881842000 CPFDGCNkKFAQSTN molecular association, regulation transcription, induced DNA(DISRUPTS) 35024765 1 1 0 +IRF3 IRF3 DNA-binding; Transcription factor Q14653 3661 19q13.33 human T180-p 28095000 SPSLDNPtPFPNLGP molecular association, regulation transcription, inhibited IRF7(INDUCES) 23685991; 24275658 3 1 0 Formation of IRF3:IRF7 dimers +TNKS TNKS EC 2.4.2.30; Transferase O95271 8658 8p23.1 human T982-p 471334 SLISPAStPSCLSAA protein stabilization; intracellular localization; enzymatic activity, induced cell cycle regulation; cell growth, induced 21818122 2 0 0 +EDNRA EDNRA GPCR, family 1; Membrane protein, integral; Membrane protein, multi-pass; Motility/polarity/chemotaxis; Receptor, GPCR P25101 1909 4q31.22-q31.23 human S391-p 2911717 LCCCCYQsKSLMTSV receptor desensitization, induced 24064210 1 1 0 Lack of S397, T403 and S404 influences desensitization to a greater extent compared than S391, S393, and T396 +CD247 CD3Z Membrane protein, integral; Receptor, misc. P20963 919 1q24.2 human Y142-p 448932 GKGHDGLyQGLSTAT ITAM molecular association, regulation; intracellular localization; protein conformation; phosphorylation carcinogenesis, inhibited; cell growth, induced; signaling pathway regulation PI4K2A(INDUCES); SHC1(INDUCES) 16337488; 16919488; 19229850; 23202272; 30131370; 33676898 15 24 410 induces T- cell activation +TIAM1 TIAM1 GEF; GEF, Rac/Rho; Motility/polarity/chemotaxis; Oncoprotein Q13009 7074 21q22.11 human S172-p 11485306 FKKKRSKsADIWRED protein stabilization; molecular association, regulation 14-3-3 beta(INDUCES) 25746002 2 4 0 +EPOR EPOR Membrane protein, integral; Receptor, cytokine P19235 2057 19p13.2 human Y454-p 455531 PTPPHLKyLYLVVSD molecular association, regulation apoptosis, inhibited SHIP(INDUCES); SOCS3(INDUCES) 10660611; 12027890; 14662339 6 0 0 +ACTB ACTB Cytoskeletal; Motility/polarity/chemotaxis P60709 60 7p22.1 human K328-ac 3814584 APSTMKIkIIAPPER Actin molecular association, regulation TPM1(DISRUPTS); MYO3B(INDUCES) 32873710 1 6 20 K328 modulates muscle contraction by disrupting inhibitory tropomysin positioning +ADAM17 TACE EC 3.4.24.86; Membrane protein, integral; Motility/polarity/chemotaxis; Protease P78536 6868 2p25.1 human T735-p 449804 KPFPAPQtPGRLQPA activity, induced; intracellular localization; enzymatic activity, induced cell cycle regulation; carcinogenesis, induced; apoptosis, induced; cell growth, induced; apoptosis, inhibited 12058067; 20188673; 21586567; 23955714; 34743207; 37046278 18 15 6 +Calm1 Calmodulin Calcium-binding; Protein phosphatase, regulatory subunit P0DP29 24242 6q32 rat T45-p 469598 RSLGQNPtEAELQDM EF-hand_7 molecular association, regulation CAMK2A(NOT_REPORTED) 12392717 1 0 0 no effects on CaM-kinase I and IV or CaM-kinase kinase alpha activity. ; non-phosphorylated calmodulin activates CaM-kinase II more than calmodulin phosphorylated on T44 by CaM-kinase IV +TOPBP1 TOPBP1 DNA replication Q92547 11073 3q22.1 human S1159-p 472408 EERARLAsNLQWPSC molecular association, regulation; protein conformation; phosphorylation cell cycle regulation; transcription, induced; transcription, inhibited TOPBP1(INDUCES); ATR(DISRUPTS); E2F1(INDUCES) DNA(DISRUPTS) 17913746; 19477925; 24081328 4 0 11 Phosphorylation and oligomerization induce enhancement of Ets-1 transcription and cooperation with TCF20.; inhibits Chk1 phosphorylation +DNAJB2 DNAJB2 Chaperone P25686 3300 2q35 human S250-p 34499810 CPLDSDLsEDEDLQL molecular association, regulation 28031292 1 4 0 phosphorylation reduced its ability to bind ubiquitylated clients, and chaperone activity +Rela NFkB-p65 DNA-binding; Nuclear receptor co-regulator; Transcription factor Q7TQN4 309165 1q43 rat S535-p 447800 SGDEDFSsIADMDFS autophagy, induced; apoptosis, induced; apoptosis, inhibited; transcription, induced; signaling pathway regulation 21550382; 21904602; 33520106; 35917315; 37237886 254 4 0 +CARHSP1 CARHSP1 RNA-binding Q9Y2V2 23589 16p13.2 human S41-p 455702 LRGNVVPsPLPTRRT molecular association, regulation; intracellular localization DNA(DISRUPTS) 21177848 3 99 187 phosphomimetic S41D mutation abolishes the ssDNA binding in vitro and releases CaRHSP1 from stress granules +GAB2 GAB2 Adaptor/scaffold Q9UQC2 9846 11q14.1 human Y614-p 449788 KSTGSVDyLALDFQP molecular association, regulation; phosphorylation cell cycle regulation; transcription, altered SHP-2(NOT_REPORTED); SHP-2(INDUCES) 11334882; 11572860; 15170389; 18644434; 23980151 6 8 55 Binding of SHP-2 activates the MAPK pathway and transcription. +H4c2 H4 DNA-binding P62806 326620 13|13 A3.1 mouse K16-ac 458960 GLGKGGAkRHRKVLR protein degradation cell cycle regulation; chromatin organization, altered; apoptosis, induced; transcription, induced; transcription, altered 17344422; 17530637; 17823087; 20710121; 23394119; 23468428; 25519132; 31437213 106 26 531 Arrested round spermatids containing PSMA8 are involved in acetyation-dependent degradation of histones during prophase I. +CTNND1 CTNND1 Actin-binding; Adaptor/scaffold; Cell adhesion; G protein regulator, misc.; Motility/polarity/chemotaxis O60716 1500 11q12.1 human S288-p 450452 GLEDDQRsMGYDDLD carcinogenesis, induced; cell motility, induced; cell adhesion, inhibited 32589661 7 35 27 +RELA NFkB-p65 DNA-binding; Nuclear receptor co-regulator; Transcription factor Q04206 5970 11q13.1 human T254-p 450278 QVAIVFRtPPYADPS RHD_dimer activity, induced; protein stabilization; molecular association, regulation; intracellular localization transcription, induced; signaling pathway regulation; transcription, altered PIN1(INDUCES) 14690596; 26729520; 34034759; 35487976 5 0 1 +SPIN1 SPIN1 DNA-binding; Nucleolus Q9Y657 10927 9q22.1 human S124-p 3217695 RVATSRIsDAHLADT molecular association, regulation carcinogenesis, induced; cell growth, induced; transcription, induced; signaling pathway regulation TCF4(INDUCES) 22258766 1 21 1 induces WNT/TCF signaling +Lat2 LAB Adaptor/scaffold; Membrane protein, integral Q9JHL0 56743 5|5 G2 mouse Y121-p 454709 VDPIPTNyYNWGCFQ LAT2 signaling pathway regulation 22308309 2 1 19 plays a negative role in TCR and FcRI-mediated and no role in LPS-mediated signaling +E2F1 E2F1 DNA-binding; Transcription factor Q01094 1869 20q11.22 human S31-p 447867 ALRLLDSsQIVIISA protein stabilization apoptosis, induced; transcription, induced 11459832; 22184068 3 0 0 etoposide-induced DNA damage, pRB-free form of E2F1, does not bind to pRB; both complexes act in parallel to induce transcription of proapoptotic genes +CHEK2 Chk2 EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, CAMK; Protein kinase, Ser/Thr (non-receptor); Tumor suppressor O96017 11200 22q12.1 human S33-p 447549 TQSQGSSsQSQGISS molecular association, regulation; enzymatic activity, induced cell cycle regulation Chk2(INDUCES); PPP2CA(DISRUPTS) 16940182; 20160490 11 1 0 S19A mutant shows impaired dimerization and does not promote Hdmx degradation +RBBP8 CtIP EC 3.1.-.-; Transcription, coactivator/corepressor Q99708 5932 18q11.2 human S276-p 28058803 SETQGPMsPLGDELY protein degradation; molecular association, regulation; ubiquitination; protein conformation; enzymatic activity, induced; phosphorylation DNA repair, altered PIN1(INDUCES) 23623683; 24837676 2 1 0 inhibits phosphorylation of RPA2 +PPARA PPAR-alpha DNA-binding; Nuclear receptor; UBIQUITIN LIGASE Q07869 5465 22q13.31 human S230-p 2902207 VKARVILsGKASNNP transcription, altered 15131257 1 0 0 +Cd1d1 CD1D Apoptosis; Cell surface; Lipid-binding; Membrane protein, integral P11609 12479 3 F1|3 37.91 cM mouse Y332-p 1414324300 IWRRRSAyQDIR___ molecular association, regulation Pyk2(INDUCES) 30514903 1 0 0 +CABLES1 CABLES1 Adaptor/scaffold Q8TDN4 91768 18q11.2 human T415-p 3207279 AFGARRNtIDSTSSF molecular association, regulation; phosphorylation; enzymatic activity, induced carcinogenesis, induced; apoptosis, inhibited; transcription, altered 14-3-3 gamma(INDUCES); CDK2(DISRUPTS) 25361894 1 22 74 inhibits phosphorylation of Cdk2 and increases its kinase activity, decreaes p21 and increases phosphorylated Rb protein levels +ULK1 ULK1 Autophagy; EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, Other; Protein kinase, Ser/Thr (non-receptor) O75385 8408 12q24.33 human S758-p 483139 PVVFTVGsPPSGSTP molecular association, regulation; enzymatic activity, inhibited; phosphorylation carcinogenesis, induced; carcinogenesis, inhibited; apoptosis, induced; cell growth, inhibited; signaling pathway regulation; transcription, altered; autophagy, induced; cell growth, induced; autophagy, altered; autophagy, inhibited AMPKA1(INDUCES) 21383122; 24998849; 26687599; 30021155; 30093610; 32134989; 34336098; 34482636; 34546793; 34604061; 34624079; 34673774; 34759263; 34820368; 35017646; 35368866; 35443161; 36008391; 36476874 78 15 2 +DUSP16 DUSP16 EC 3.1.3.16; EC 3.1.3.48; PHOSPHATASE; Protein phosphatase, dual-specificity Q9BY84 80824 12p13.2 human S446-p 449606 TNKLCQFsPVQELSE protein stabilization 15689616 2 3 0 +ESR1 ER-alpha DNA-binding; Nuclear receptor; Transcription factor P03372 2099 6q25.1-q25.2 human T594-p 28070700 EAEGFPAtV______ ESR1_C molecular association, regulation transcription, altered; cell growth, altered 14-3-3 beta(INDUCES); 14-3-3 sigma(INDUCES); 14-3-3 zeta(INDUCES); 14-3-3 epsilon(INDUCES); 14-3-3 gamma(INDUCES); 14-3-3 eta(INDUCES); ER-alpha(INDUCES) 23676274 1 1 0 interaction with 14-3-3 protein has a negative effect on receptor dimerization; receptor dimerization +SRF SRF Motility/polarity/chemotaxis; Transcription factor P11831 6722 6p21.1 human T159-p 449631 DNKLRRYtTFSKRKT SRF-TF activity, induced transcription, induced; transcription, inhibited 12809504; 19778940 2 0 0 +PDPK1 PDK1 EC 2.7.11.1; KINASE; Kinase, protein; Nuclear receptor co-regulator; Protein kinase, AGC; Protein kinase, Ser/Thr (non-receptor) O15530 5170 16p13.3 human S64-p 27457101 EPRPGAGsLQHAQPP protein stabilization 28152304 1 2 0 T cell activation, IL-2 production, enhances TCR/CD28 mediated NF-KB activit +Mecp2 MECP2 Transcription, coactivator/corepressor Q9Z2D6 17257 X A7.3|X 37.63 cM mouse T308-p 28699600 LPIKKRKtRETVSIE molecular association, regulation; activity, inhibited transcription, induced N-CoR1(DISRUPTS) DNA(INDUCES) 23770587 2 0 0 +COIL coilin Oxidoreductase P38432 8161 17q22 human S272-p 6421922 TLEARNSsEKLPTEL cell growth, inhibited 21991343 1 8 0 Cajal body formation, phosphomutant cell lines show a significant reduction in CB formation compared to wild-type after endogenous coilin knockdown +Scimp UNQ5783 Membrane protein, integral Q3UU41 327957 11|11 B3 mouse Y58-p 3975471 GRDEEKMyENVLNSS SCIMP molecular association, regulation transcription, induced GRB2(INDUCES); TLR4(INDUCES); CSK(INDUCES); TLR2(INDUCES); BLNK(INDUCES); TLR1(INDUCES); TLR3(INDUCES) 34496234; 35337798 2 1 1 +Cd3e CD3E Membrane protein, integral; Receptor, misc. P22646 12501 9 A5.2|9 24.84 cM mouse Y170-p 448918 PPVPNPDyEPIRKGQ ITAM molecular association, regulation PIK3R1(INDUCES) 9312149 5 12 382 +DRD3 DRD3 GPCR, family 1; Membrane protein, integral; Membrane protein, multi-pass; Receptor, GPCR P35462 1814 3q13.31 human S229-p 482885 RILTRQNsQCNSVRP 7tm_1 receptor desensitization, altered; receptor internalization, altered 17536008 2 0 0 +Gorasp1 GRASP65 Vesicle O35254 56082 8q32 rat T220-p 4768150 PSASSPGtPAKTPQP intracellular localization cell cycle regulation 23259055 1 7 0 Regulation of mitotic golgi disassembly and reassembly; inactivation of T220/T224, and eventually S277partial dephosphorylation +ADRA1D ADRA1D GPCR, family 1; Membrane protein, integral; Membrane protein, multi-pass; Receptor, GPCR P25100 146 20p13 human S331-p 1424270004 AKGHTFRsSLSVRLL 7tm_1 receptor internalization, altered signaling pathway regulation 29551601 1 1 0 regulates ERK signaling pathway, induces calcium signaling de-sensitization +BLNK BLNK Adaptor/scaffold Q9YGC1 395733 chicken S173-p 1868112506 PKKPSLPsPAAKPKL phosphorylation transcription, altered 19372136 1 1 0 +PDGFRB PDGFRB EC 2.7.10.1; KINASE; Kinase, protein; Membrane protein, integral; Oncoprotein; Protein kinase, TK; Protein kinase, tyrosine (receptor) P09619 5159 5q32 human Y1009-p 447522 LDTSSVLyTAVQPNE activity, induced; molecular association, regulation; phosphorylation cell growth, altered SH3KBP1(INDUCES); PLCG1(INDUCES); SHP-2(INDUCES); PIK3R1(DISRUPTS); RASA1(DISRUPTS); CBL(INDUCES) 10391677; 11864611; 11896619; 12177062; 1396585; 17403678; 7545675; 7935391; 9673410 17 0 0 Stimulation with EGF or PDGF SH3SKP1 induced minimal increase in association. Association is constitutive in tumor cell lines.; Y1009 and Y1021 phosphorylation mediates PDGFBB and thrombin induced calcium signaling. +TP53BP1 53BP1 DNA repair, damage; Transcription, coactivator/corepressor Q12888 7158 15q15.3 human S1317-p 476252 SSLHRTSsGTSLSAM molecular association, regulation; intracellular localization; phosphorylation DNA repair, induced; apoptosis, inhibited H4(INDUCES) 33596428 1 19 21 regulates phosphorylation of CHK2, ATM, DNA-PK +HDAC4 HDAC4 DEACETYLASE; Deacetylase; EC 3.5.1.98; Hydrolase; Nuclear receptor co-regulator; SUMO LIGASE P56524 9759 2q37.3 human S210-p 2631600 YGKTQHSsLDQSSPP transcription, altered 17179159 1 4 0 +CTNNB1 CTNNB1 Actin-binding; Cell adhesion; Motility/polarity/chemotaxis; Nuclear receptor co-regulator; Oncoprotein; Transcription factor P35222 1499 3p22.1 human Y142-p 449044 AVVNLINyQDDAELA protein degradation; molecular association, regulation; intracellular localization carcinogenesis, induced; cell growth, induced; apoptosis, inhibited; transcription, induced; cytoskeletal reorganization; signaling pathway regulation Bcl-9L(INDUCES); CTNNA1(DISRUPTS); CTNNA1(INDUCES) 15371335; 22558232; 24240237; 30747223; 34227224 16 2 0 TCF/LEF pathway +APLNR APLNR GPCR, family 1; Membrane protein, integral; Membrane protein, multi-pass; Receptor, GPCR P35414 187 11q12.1 human S348-p 36436800 EKSASYSsGHSQGPG receptor internalization, induced; receptor desensitization, induced; molecular association, regulation; phosphorylation GRK5(INDUCES); ARRB1(INDUCES); GRK2(INDUCES); ARRB2(INDUCES) 25271156 1 2 0 enhanced ERK1/2 phosphorylation +KMT5A SETD8 Amino Acid Metabolism - lysine degradation; EC 2.1.1.43; METHYLTRANSFERASE; Methyltransferase; Methyltransferase, protein lysine Q9NQR1 387893 12q24.31 human K151-sm 25090303 NAVRSAMkSEEQKIK transcription, inhibited 21829513 1 0 0 +Hnrnpf hnRNP F RNA splicing; RNA-binding; Spliceosome Q794E4 64200 4q42 rat K224-ac 11320524 RRYIGIVkQAGLDRM protein stabilization RNA splicing, induced 25959059 1 2 3 +KCNK18 KCNK18 Channel, ligand-gated; Channel, potassium; Membrane protein, integral; Membrane protein, multi-pass Q7Z418 338567 10q25.3 human S264-p 12525800 VLGRLSYsIISNLDE intracellular localization; activity, inhibited transcription, inhibited 25202008; 30327410; 30992311 8 0 0 +GLRB GLRB Channel, ligand-gated; Membrane protein, integral; Membrane protein, multi-pass; Transporter; Transporter, ion channel P48167 2743 4q32.1 human Y435-p 3078004 RDFELSNyDCYGKPI Neur_chan_memb activity, induced 11882681 1 0 0 +TRPV5 TRPV5 Channel, cation; Membrane protein, integral; Membrane protein, multi-pass; Motility/polarity/chemotaxis Q9NQA5 56302 7q34 human S299-p 470108 FLELVVSsDKREARQ activity, induced; intracellular localization 17006539 3 0 0 +WTAP WTAP Nucleolus; Spliceosome Q15007 9589 6q25.3 human S306-p 453808 TEDDFPSsPGNGNKS cell differentiation, induced 33217317 1 37 127 +RGS4 RGS4 GAP; GAP, RGS Q0R4E4 100009014 rabbit S52-p 469585 VVVCQRVsQEEVKKW molecular association, regulation; intracellular localization G-alpha(q)(INDUCES) 16885398 1 0 0 +IRF3 IRF3 DNA-binding; Transcription factor Q14653 3661 19q13.33 human T404-p 449031 NSHPLSLtSDQYKAY activity, induced; protein degradation; molecular association, regulation; intracellular localization; protein conformation; phosphorylation autophagy, induced; transcription, induced; transcription, altered CALCOCO2(INDUCES); CBP(INDUCES) 17526488; 18272581; 19153595; 25070846; 27992402; 37330913; 9566918 9 2 0 GPR108 and Smurf1 mediated degradation requires NDP52; NDP52-dependent autophagic degradation of phosphorylated IRF3; GPR108 interacts with Smurf1, followed by the recruitment of IRF3 during viral infection +Cacna1b CACNA1B Channel, calcium; Membrane protein, integral; Membrane protein, multi-pass Q02294 257648 3p13 rat S2126-p 467286 SEKQRFYsCDRFGSR molecular association, regulation 14-3-3 gamma(INDUCES) 16982421 1 1 0 +AICDA AID EC 3.5.4.38; Hydrolase Q9GZX7 57379 12p13.31 human S3-p 20660600 _____MDsLLMNRRK protein degradation cell cycle regulation 26355458 2 0 0 +TOP1 TOP1 EC 5.99.1.2; Isomerase; Nucleolus; Oncoprotein P11387 7150 20q12 human S506-p 27276101 ADTVGCCsLRVEHIN Topoisom_I molecular association, regulation ARF1(INDUCES) DNA(INDUCES) 23185622; 23555599 3 0 0 ARF enhances the binding of hyperphosphorylated S506 to DNA. ; enhances relaxation of supercoiled DNA by increasing TOP1 DNA binding +DEK DEK DNA replication; DNA-binding; Histone-binding; Oncoprotein; RNA splicing P35659 7913 6p22.3 human T67-p 27777400 KKKVERLtMQVSSLQ protein degradation; molecular association, regulation RNA splicing, induced FBXW7(INDUCES) 21282377 2 2 0 regulates tropomyosin alternative splicing +Pten PTEN Carbohydrate Metabolism - inositol phosphate; EC 3.1.3.16; EC 3.1.3.48; EC 3.1.3.67; Motility/polarity/chemotaxis; Nuclear receptor co-regulator; PHOSPHATASE; Phosphatase, lipid; Tumor suppressor O08586 19211 19 C1|19 28.14 cM mouse T382-p 448314 DHYRYSDtTDSDPEN enzymatic activity, inhibited 24367090 22 2 0 +TTK TTK Cancer Testis Antigen (CTA); EC 2.7.12.1; KINASE; Kinase, protein; Protein kinase, Other; Protein kinase, dual-specificity (non-receptor) P33981 7272 6q14.1 human T468-p 471488 DYMSCFRtPVVKNDF activity, induced; molecular association, regulation; protein stabilization cell cycle regulation CDKN3(INDUCES) 17804818; 26586430 2 2 2 regulates centrosomes duplication and a cell cycle; regulates TTK stability and as a result its accumulation at centrosomes; recruiting Cdkn3 to centrosomes, interaction is required for maintaining the proper number of centrosomes +Npm1 NPM1 Nucleolus; Oncoprotein; RNA-binding; Translation Q61937 18148 11|11 A4 mouse T198-p 448515 VKKSVRDtPAKNAQK molecular association, regulation; intracellular localization cell cycle regulation; RNA splicing, altered; cytoskeletal reorganization ROCK2(INDUCES) RNA(INDUCES) 16376875; 17015463; 19933848 24 29 30 centrosome duplication +Wasl N-WASP Adaptor/scaffold; Motility/polarity/chemotaxis O08816 682507 4q22 rat S239-p 457322 LFDMCGIsEAQLKDR PBD cytoskeletal reorganization 16257963 1 0 0 phosphorylation of this site plays a role in regulation of actin polymerization +TGFBR3 TGFBR3 Membrane protein, integral Q03167 7049 1p22.1 human T843-p 455562 SIGSTQStPCSSSST molecular association, regulation; receptor internalization, altered; intracellular localization ARRB1(INDUCES) 12958365 1 0 0 +Map3k7 TAK1 EC 2.7.11.25; KINASE; Kinase, protein; Protein kinase, Ser/Thr (non-receptor); Protein kinase, TKL Q62073 26409 4|4 A5 mouse T187-p 454704 CDIQTHMtNNKGSAA PK_Tyr_Ser-Thr phosphorylation carcinogenesis, induced; transcription, induced; signaling pathway regulation 27542620; 35051616 33 1 0 +IRAK1 IRAK1 EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, Ser/Thr (non-receptor); Protein kinase, TKL P51617 3654 Xq28 human S375-p 31085747 AGSSPSQsSMVARTQ Pkinase enzymatic activity, induced 29208712 0 2 0 +JADE1 JADE1 Tumor suppressor Q6IE81 79960 4q28.2 human S18-p 35530402 EDSDDNGsLSTTWSQ EPL1 protein stabilization; activity, inhibited cell differentiation, induced; transcription, induced; signaling pathway regulation 25100726 1 1 0 impairs the ability of Jade-1S to inhibit Wnt reporter activity; Decrease the ability of Jade-1 to inhibit ?-catenin signaling +RNF146 RNF146 EC 6.3.2.-; EC 6.3.2.19; UBIQUITIN LIGASE; Ubiquitin conjugating system; Ubiquitin ligase Q9NTX7 81847 6q22.33 human K176-sm 1883827102 DIIDIPKkGVAGLRL protein degradation cell growth, induced 37029301 1 0 0 degradation of Axin and upregulation of ?-catenin, progression of HCC cells, abolishing RNF146 SUMOylation inhibits HCC cell tumorigenesis +STMN1 STMN1 Cytoskeletal P16949 3925 1p36.11 human K9-ac 3856124 ASSDIQVkELEKRAS Stathmin protein stabilization; phosphorylation TUBA1A(INDUCES); RNF12(DISRUPTS) 35581193 1 2 1 K9 acetylation inhibits S25 phosphorylation, induces interaction with tubulin and inhibits interaction with RNF12. +Nrip1 RIP140 Nuclear receptor co-regulator; Transcription, coactivator/corepressor Q8CBD1 268903 16|16 C3.1 mouse K287-ac 459036 YSREHALkTQNAHQV NRIP1_repr_1 activity, induced; intracellular localization transcription, inhibited 15879431; 18655826 1 2 0 enhanced fat accumulation in differentiated adipocytes +NTRK3 TrkC EC 2.7.10.1; KINASE; Kinase, protein; Membrane protein, integral; Protein kinase, TK; Protein kinase, tyrosine (receptor) Q16288 4916 15q25.3 human Y709-p 464877 RDVYSTDyYRLFNPS PK_Tyr_Ser-Thr carcinogenesis, induced; signaling pathway regulation 10702799 1 1 29 +Mafa MAFA DNA-binding; Oncoprotein; Transcription factor; Tumor suppressor Q8CF90 378435 15|15 D3 mouse T53-p 1320402 PPGSLSStPLSTPCS protein degradation; molecular association, regulation transcription, inhibited MAFA(INDUCES); PSME3(INDUCES) DNA(NOT_REPORTED) 20208071; 21646385 4 1 0 +CTPS2 CTPS2 EC 6.3.4.2; Ligase; Nucleotide Metabolism - pyrimidine Q9NRF8 56474 Xp22.2 human S568-p 3213615 LSSSDRYsDASDDSF enzymatic activity, inhibited 20739275 1 41 5 +TBK1 TBK1 EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, Other; Protein kinase, Ser/Thr (non-receptor) Q9UHD2 29110 12q14.2 human R134-me 1881361502 RENGIVHrDIKPGNI enzymatic activity, induced 34551290 1 0 0 TBK1 aggregation, PRMT1 positively regulates antiviral immune responses, and promotes cellular innate antiviral signaling +Stmn1 STMN1 Cytoskeletal P13668 29332 5q36 rat S63-p 448557 AAEERRKsHEAEVLK Stathmin cytoskeletal reorganization 24302736; 31933182 26 56 32 increase microtubule depolymerization; Regulates tubulin polymerization +CDCA5 CDCA5 Cell cycle regulation Q96FF9 113130 11q13.1 human T111-p 469415 KTHSVPAtPTSTPVP Sororin molecular association, regulation; activity, inhibited cell cycle regulation SCC-112(DISRUPTS); H2A.1(DISRUPTS); SMC3(DISRUPTS) 21878504; 23901111 2 6 15 +NCAM1 NCAM1 iso1 Cell adhesion; Membrane protein, GPI anchor; Membrane protein, integral; Motility/polarity/chemotaxis P13591-1 4684 11q23.2 human T803-p 15721468 HTEPNETtPLTEPEK endocytosis, induced; cell growth, inhibited 28193531 1 2 0 shorter neurite outgrowth +Nfya NFYA DNA-binding; Transcription factor P23708 18044 17 C|17 23.99 cM mouse K283-ub 4664704 KRRQARAkLEAEGKI CBFB_NFYA protein degradation cell growth, inhibited; transcription, inhibited 18815279 1 0 0 +CD28 CD28 Cell surface; Membrane protein, integral P10747 940 2q33.2 human Y206-p 450283 PGPTRKHyQPYAPPR phosphorylation carcinogenesis, inhibited; cell growth, inhibited; signaling pathway regulation 20368329; 30131370 3 3 168 +STAT6 STAT6 DNA-binding; Transcription factor P42226 6778 12q13.3 human S707-p 17772900 IPPYQGLsPEESVNV STAT6_C molecular association, regulation transcription, inhibited DNA(NOT_REPORTED) 21123173 1 0 0 suppresses transcriptional activity of STAT6 +SMPD3 SMPD3 EC 3.1.4.12; Lipid Metabolism - sphingolipid; Membrane protein, integral; Phospholipase Q9NY59 55512 16q22.1 human K103-ub 1880099300 IYSRLEDkGLAGGAA protein degradation 36261549 1 0 0 +RPL11 RPL11 Motility/polarity/chemotaxis; Nucleolus; Ribosomal; Translation P62913 6135 1p36.11 human K88-ne 12067609 EILEKGLkVREYELR Ribosomal_L5_C protein stabilization; intracellular localization 19713960 1 0 0 +GPR3 GPR3 Cell cycle regulation; GPCR, family 1; Membrane protein, integral; Membrane protein, multi-pass; Receptor, GPCR P46089 2827 1p36.11 human S237-p 29649502 QRHLLPAsHYVATRK 7tm_1 molecular association, regulation; intracellular localization ARRB1(DISRUPTS); APP(DISRUPTS) 24069330 1 0 0 237A mutant stimulates production of beta-amyloid and shows enhanced GPR3 clustering. ; colocalization with Amyloid Precursor Protein +MRE11 MRE11A Cell cycle regulation; DNA repair, damage; DNA-binding; Deoxyribonuclease P49959 4361 11q21 human R576-me 2344813 GRGRGRGrRGGRGQN intracellular localization 15970667 1 0 0 localizes in nucleus and associates with nuclear bodies and sites of DNA damage +UBAP2L NICE-4 RNA-binding; Ubiquitin conjugating system Q14157 9898 1q21.3 human R190-m2 27280776 GSGRRGGrFSAQGMG molecular association, regulation 31114027 1 3 1 regulation of stress-granule dynamics by NICE-4 arginine methylation +DAXX DAXX Apoptosis; Nuclear receptor co-regulator; Nucleolus; Transcription, coactivator/corepressor Q9UER7 1616 6p21.32 human K631-sm 2407411 DSGPPCKkSRKEKKQ molecular association, regulation; intracellular localization cell growth, inhibited; transcription, inhibited PML(INDUCES) 16818774 4 0 0 +Pkm PKM Carbohydrate Metabolism - glycolysis and gluconeogenesis; Carbohydrate Metabolism - pyruvate; EC 2.7.1.40; KINASE; Kinase, other; Mitochondrial; Nucleotide Metabolism - purine P52480 18746 9 B|9 32.03 cM mouse S37-p 476070 MCRLDIDsAPITARN intracellular localization apoptosis, induced 35637461; 36322626; 37126714 17 62 6 +Dpysl5 CRMP-5 Q9EQF6 65254 5|5 B1 mouse T514-p 478231 MGTPLADtPTRPVTR phosphorylation 29758318 1 8 2 S522A KI mice +Irs2 IRS2 Adaptor/scaffold; Motility/polarity/chemotaxis P81122 384783 8 A1.1|8 5.35 cM mouse Y911-p 3217416 EPKSPGEyINIDFGE signaling pathway regulation 23775122 2 3 2 +SMAD1 SMAD1 DNA-binding; Transcription factor Q15797 4086 4q31.21 human T322-p 25802105 SNVNRNStIENTRRH MH2 activity, inhibited; phosphorylation 21690388 2 4 0 phosphorylation of the site inhibits phosphorylation of the C-terminal domain of SMAD1. +SMAD3 SMAD3 DNA-binding; Nuclear receptor co-regulator; Transcription factor P84022 4088 15q22.33 human S264-p 1868957100 VDGFTDPsNSERFCL MH2 protein stabilization; activity, inhibited; phosphorylation cell differentiation, inhibited; cell growth, induced; transcription, inhibited; signaling pathway regulation 32232430 1 0 0 inhibits self phosphorylation and TGFB/SMAD pathway +Fcor FcoR P0DJI6 100503924 8|8 A1.1 mouse T93-p 25244200 DLNSQRStCCCLLNA acetylation; intracellular localization transcription, inhibited 22510882 1 0 0 suppresses expression of PGC-1alpha; increases FoxoO1 acetylation and inhibits its transcriptional activity +DAB1 DAB1 Adaptor/scaffold Q8JH94 374083 chicken Y198-p 447629 EDVEDPVyQYIVFEA phosphorylation cytoskeletal reorganization 15057276 11 1 0 increases Src activation and overall tyrosine phosphorylation levels in the cell, alters cellular morphology +MLKL MLKL KINASE; Kinase, protein; Protein kinase, Ser/Thr (non-receptor); Protein kinase, TKL Q8NB16 197259 16q23.1 human Y376-p 1868624704 DRVKSTAyLSPQELE PK_Tyr_Ser-Thr protein stabilization; molecular association, regulation MLKL(INDUCES) 31230815 1 1 0 promotes necroptosis +NFATC1 NFAT2 DNA-binding; Transcription factor O95644 4772 18q23 human S245-p 448861 PSTSPRAsVTEESWL activity, induced; intracellular localization; activity, inhibited; phosphorylation carcinogenesis, induced; cell motility, induced; transcription, induced 12351631; 31730483; 9072970 3 7 1 phosphorylation creates predicted overlapping GSK3B phosphorylation sites; multiple sites mutatnt +PLD1 PLD1 iso2 EC 3.1.4.4; Lipid Metabolism - ether lipid; Lipid Metabolism - glycerophospholipid; Motility/polarity/chemotaxis; Phospholipase Q13393-2 5337 3q26.31 human S2-p 448572 ______MsLKNEPRV intracellular localization; enzymatic activity, induced 16978840 4 2 0 +XRCC5 Ku80 DNA-binding; EC 3.6.1.-; EC 3.6.4.-; Helicase; Nuclear receptor co-regulator; Nucleolus; RNA-binding P13010 7520 2q35 human K195-ub 10835386 HGPSFPLkGITEQQK Ku_N molecular association, regulation DNA repair, induced DNA(DISRUPTS) 27895153 1 9 86 +DAB2IP DAB2IP iso2 GAP; GAP, Ras; Tumor suppressor Q5VWQ8-2 153090 9q33.2 human T546-p 3958578 GTNDLAStPGSGSSS DUF3498 ubiquitination; phosphorylation cell cycle regulation; carcinogenesis, inhibited; chromatin organization, altered; cytoskeletal reorganization PLK1(INDUCES) 34775484 1 1 2 inhibitrs CDC20 ubiquitination, induces PLK1, TTK phosphorylation +GAPDH GAPDH Carbohydrate Metabolism - glycolysis and gluconeogenesis; EC 1.2.1.12; Oxidoreductase P04406 2597 12p13.31 human K227-ac 461582 VIPELNGkLTGMAFR Gp_dh_C intracellular localization 20601085 1 6 22 nuclear translocation +Atp1b1 ATP1B1 Membrane protein, integral; Transporter P07340 25650 13q23 rat S11-p 29573988 GKAKEEGsWKKFIWN Na_K-ATPase protein degradation; molecular association, regulation; ubiquitination endocytosis, induced TRAF2(INDUCES) 34277634 1 2 0 +TET1 TET1 DNA-binding; EC 1.14.11.n2; Oxidoreductase Q8NFU7 80312 10q21.3 human K1589-ub 38497600 SMYFNGCkFGRSPSP Tet_JBP intracellular localization; enzymatic activity, induced 25557551 1 0 0 +Flcn FLCN Tumor suppressor Q76JQ2 303185 10q22 rat S302-p 3206871 ESESWDNsEAEEEEK molecular association, regulation AMPKA1(DISRUPTS) 19695222 1 16 0 +JUN Jun Oncoprotein; Transcription factor P05412 3725 1p32.1 human T2-p 17737603 ______MtAKMETTF carcinogenesis, altered; cell growth, altered 21177766 1 0 0 +Nr2e3 NR2E3 Nuclear receptor Q9QXZ7 23958 9 B|9 32.35 cM mouse K315-sm 7324002 LKALVLFkPETRGLK Hormone_recep transcription, inhibited 19186166 1 0 0 +Optn optineurin Inhibitor Q8K3K8 71648 2 A1|2 3.15 cM mouse S517-p 21214714 EEGGSRQsLMEMQCR autophagy, induced 33931895 4 5 0 regulates mitochondrial homeostasis and pluripotency +Ldb3 LDB3 Cytoskeletal Q9JKS4 24131 14|14 B mouse S265-p 10364530 DEWARRSsNLQSRSF DUF4749 phosphorylation cytoskeletal reorganization; signaling pathway regulation 23996002 1 1 2 facilitated PKA-mediated phosphorylation, sarcomere signaling center +AQP9 AQP9 Channel, misc.; Membrane protein, integral; Membrane protein, multi-pass; Transporter; Transporter, aquaporin family O43315 366 15q21.3 human S222-p 477184 MNPARDLsPRLFTAL MIP cytoskeletal reorganization 17346701; 28419510 2 1 0 mutation decreases sensitivity to hypo-osmolar conditions and formation of filopodia; ?lopodia formation +TRAF3 TRAF3 UBIQUITIN LIGASE; Ubiquitin conjugating system; Ubiquitin ligase Q13114 7187 14q32.32 human S349-p 8098598 QNWEEADsMKSSVES molecular association, regulation; ubiquitination transcription, induced TBK1(INDUCES) 26928339 1 2 1 virus-induced production of type I interferons, TRAF3-TBK1?induced luciferase activity of the IFN-? reporter +SHC1 SHC1 Adaptor/scaffold; Apoptosis; Mitochondrial; Motility/polarity/chemotaxis P29353 6464 1q21.3 human T386-p 457351 PTAPNAQtPSHLGAT protein stabilization apoptosis, induced 16251354 1 1 1 Phosphorylation necessary to promote activated-Rac1-induced oxidative stress (ROS-induced apoptosis). +CCR5 CCR5 GPCR, family 1; Membrane protein, integral; Membrane protein, multi-pass; Motility/polarity/chemotaxis; Receptor, GPCR; Receptor, cytokine P51681 1234 3p21.31 human S337-p 448725 EAPERASsVYTRSTG molecular association, regulation; receptor desensitization, altered; receptor internalization, altered ARRB1(INDUCES); ARRB2(INDUCES) 10085131; 11782464; 12065593 3 0 0 +Hnrnpk hnRNP K RNA splicing; RNA-binding; Spliceosome P61979 15387 13|13 B1 mouse S116-p 452369 EEGLQLPsPTATSQL intracellular localization 20960454 4 38 22 +Adcy6 ADCY6 Adenylyl cyclase; EC 4.6.1.1; Lyase; Membrane protein, integral; Membrane protein, multi-pass; Nucleotide Metabolism - purine; Transporter; Transporter, aquaporin family AAA40678 25289 7q36 rat S746-p 467273 ALQRLSRsIVRSRVH enzymatic activity, induced 11327830; 15470083 2 0 0 increases potentiation +PRKN PARK2 EC 6.3.2.-; EC 6.3.2.19; Ligase; Translation; Translation regulation; UBIQUITIN LIGASE; Ubiquitin conjugating system; Ubiquitin ligase O60260 5071 6q26 human K220-ub 1881186502 GAHPTSDkETSVALH protein degradation; ubiquitination 33565245 1 0 0 +NDUFA12 NDUFA12 EC 1.6.5.3; EC 1.6.99.3; Mitochondrial; Oxidoreductase Q9UI09 55967 12q22 human T120-p 33402205 HKFNVTGtPEQYVPY NDUFA12 activity, induced cell cycle regulation 24746669 1 2 0 increases mitochondrial respiration for G/2M transition +ULK1 ULK1 Autophagy; EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, Other; Protein kinase, Ser/Thr (non-receptor) O75385 8408 12q24.33 human S469-p 483137 IRRSGSTsPLGFARA protein degradation; molecular association, regulation; ubiquitination; enzymatic activity, inhibited cell growth, induced; apoptosis, inhibited; autophagy, inhibited ATG13(DISRUPTS); ATG101(DISRUPTS); RB1CC1(DISRUPTS) 31378785 1 31 7 regulates resistance of gliomas to TMZ +ARRB2 ARRB2 iso2 Adaptor/scaffold P32120-2 281638 cow K397-sm 25350105 DFARLRLkGLKDEDY molecular association, regulation AP-2 beta(INDUCES) 21118812 1 0 0 GPCR endocytosis induced +HSF4 HSF4 Cell development/differentiation; DNA-binding; Transcription, coactivator/corepressor Q9ULV5 3299 16q22.1 human T471-p 30318200 LGLPGALtIYSTPES protein stabilization; ubiquitination; intracellular localization transcription, induced KPNB1(DISRUPTS) 24361130 1 1 0 upregulation of alpha-beta-crystaline and Hsp25, nuclear localization, T471A mutant promotes degradation via ubiquitin-proteasome. +DAPK2 DAPK2 EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, CAMK; Protein kinase, Ser/Thr (non-receptor) Q9UIK4 23604 15q22.31 human S318-p 450028 VRRRWKLsFSIVSLC molecular association, regulation apoptosis, altered; apoptosis, inhibited DAPK2(DISRUPTS); CAMK1A(DISRUPTS); Calmodulin(DISRUPTS) 11230133; 34413451 2 4 0 +Scn5a SCN5A Channel, sodium; Membrane protein, integral; Membrane protein, multi-pass Q9JJV9 20271 9 F3|9 71.33 cM mouse K1481-ac 63044906 NFNQQKKkLGGQDIF Ion_trans intracellular localization 28191886 3 2 0 +Nos1 nNOS Amino Acid Metabolism - arginine and proline; EC 1.14.13.39; Oxidoreductase P29476 24598 12q16 rat K1371-ac 2459111 RIMTQQGkLSEEDAG activity, induced 18415985 1 0 0 +Elk1 ELK1 DNA-binding; Transcription factor P41969 13712 X A1.3|X 16.45 cM mouse T337-p 2751400 GGQGPERtPGSGTSS molecular association, regulation transcription, inhibited Trap100(DISRUPTS); MED23(DISRUPTS); MED16(DISRUPTS) 27738173 2 0 0 +Adrb3 ADRB3 iso2 GPCR, family 1; Membrane protein, integral; Membrane protein, multi-pass; Receptor, GPCR P25962-2 11556 8 A2|8 15.94 cM mouse S388-p 456901 RQSPPLNsSLLREPR activity, induced 16144970 1 0 0 mutation of serines 388 and 389 to alanine abrogated cAMP accumulation in response to CL316243. +DNMT1 DNMT1 Amino Acid Metabolism - cysteine and methionine; Cell development/differentiation; EC 2.1.1.37; METHYLTRANSFERASE; Methyltransferase; Methyltransferase, DNA; Transcription regulation P26358 1786 19p13.2 human K675-sm 12726307 KACKDMVkFGGSGRS zf-CXXC enzymatic activity, induced DNA(INDUCES) 19450230 1 0 0 +ACE2 ACE2 EC 3.4.17.23; Membrane protein, integral; Protease Q9BYF1 59272 Xp22.2 human Y781-p 465258 ARSGENPyASIDISK molecular association, regulation LYN(INDUCES); Fyn(INDUCES); AP2M1(DISRUPTS) 33436498 2 1 12 +RAB8A RAB8A G protein; G protein, monomeric; G protein, monomeric, Rab; Motility/polarity/chemotaxis; Oncoprotein P61006 4218 19p13.11 human S111-p 20805078 RNIEEHAsADVEKMI Ras molecular association, regulation; enzymatic activity, inhibited; protein conformation; phosphorylation RAB3IP(DISRUPTS); TBC1D20(DISRUPTS) 26471730; 32227113; 34056776 3 11 0 +VDAC1 VDAC1 Channel, misc.; Membrane protein, integral; Mitochondrial P21796 7416 5q31.1 human K274-ub 486986 NVNAGGHkLGLGLEF Porin_3; TM apoptosis, inhibited 32047033 1 9 99 pathologies of PD by controlling apoptosis +ASIC1 ASIC1 Channel, cation; Membrane protein, integral; Membrane protein, multi-pass; Transporter; Transporter, ion channel P78348 41 12q13.12 human S499-p 4737851 KRHNPCEsLRGHPAG activity, inhibited 19091960 1 1 1 +PER2 PER2 Nuclear receptor co-regulator; Nucleolus; Transcription factor O15055 8864 2q37.3 human S662-gl 27717323 ALPGKAEsVASLTSQ phosphorylation 23395175 1 1 0 blocks phosphorylation at S662, regulation of circadian clock +CRK CRK Adaptor/scaffold; Motility/polarity/chemotaxis; Oncoprotein P46108 1398 17p13.3 human Y221-p 447951 GGPEPGPyAQPSVNT molecular association, regulation; intracellular localization apoptosis, induced; cell adhesion, altered; cell adhesion, inhibited Arg(INDUCES); P130Cas(INDUCES); PAX1(DISRUPTS); RAPGEF1(DISRUPTS); Abl iso2(INDUCES); CRK(INDUCES); PXN iso2(DISRUPTS) 12198159; 12799422; 12955086; 25381819; 28790195; 36079767; 8194526 25 14 1168 +CDKN2D CDKN2D Cell cycle regulation; Inhibitor; Tumor suppressor P55273 1032 19p13.2 human S76-p 6046001 VQDTSGTsPVHDAAR Ank_2 protein degradation; molecular association, regulation; ubiquitination; intracellular localization; protein conformation; phosphorylation cell cycle regulation; cell growth, induced CDK6(DISRUPTS) 19063602; 22558186; 29531090; 32874495 3 3 0 +SLC43A2 SLC43A2 Membrane protein, integral; Membrane protein, multi-pass; Transporter; Transporter, SLC family Q8N370 124935 17p13.3 human S297-p 3206079 EGHKLCLsTVDLEVK MFS_1 activity, induced; protein stabilization; intracellular localization 30379325 2 26 0 transporter activity increased, stabilize terminally glycosylated mature form, amino acid absorption +TRIB2 TRB2 KINASE; Kinase, protein; Protein kinase, CAMK; Protein kinase, Ser/Thr (non-receptor) Q92519 28951 2p24.3 human S83-p 29604200 FRAVHLHsGEELVCK Pkinase protein degradation; intracellular localization carcinogenesis, inhibited 24089522 1 0 0 +Hnf4a HNF4 alpha DNA-binding; Nuclear receptor; Transcription factor P49698 15378 2 H3|2 84.32 cM mouse S190-p 458372 NITDVCEsMKEQLLV Hormone_recep molecular association, regulation SSU72(INDUCES) 34616001 2 1 0 +Dlc1 DLC1 GAP; GAP, Rac/Rho; Tumor suppressor Q9R0Z9 50768 8 A4|8 23.05 cM mouse S129-p 20651248 KQDPIPGsPDNSRLQ molecular association, regulation; phosphorylation Src(INDUCES) 31308216 1 11 0 increases the efficiency of Src binding and Src-dependent phosphorylation of Y452 and Y702 +H1-1 H1F1 DNA-binding Q02539 3024 6p22.2 human S183-p 15605000 KPKKVAKsPAKAKAV transcription, altered 20551309 1 3 0 +CAMKK1 CAMKK1 EC 2.7.11.17; KINASE; Kinase, protein; Protein kinase, Other; Protein kinase, Ser/Thr (non-receptor) Q8N5S9 84254 17p13.2 human T108-p 452083 PRAWRRPtIESHHVA enzymatic activity, inhibited; enzymatic activity, induced 11574071 7 0 5 activity toward PKIV peptide; activity towards CAMK4. +ME1 ME1 Carbohydrate Metabolism - pyruvate; EC 1.1.1.40; Oxidoreductase P48163 4199 6q14.2 human S336-p 4701731 KKIWLVDsKGLIVKG Malic_M molecular association, regulation; acetylation; intracellular localization; activity, inhibited carcinogenesis, inhibited ME1(DISRUPTS) 31735643 1 10 0 protein dimerization decreased; decreases acetylation at K337 +LRP6 LRP6 Membrane protein, integral; Receptor, misc. O75581 4040 12p13.2 human T1479-p 457635 SSSSTKGtYFPAILN activity, induced; molecular association, regulation transcription, induced; signaling pathway regulation axin 1(INDUCES) 16341016; 17569865; 35487243 8 1 1 induces WNT signaling +NSUN2 NSUN2 EC 2.1.1.203; METHYLTRANSFERASE; Methyltransferase; Nucleolus; RNA-binding Q08J23 54888 5p15.31 human S139-p 478355 SRKILRKsPHLEKFH molecular association, regulation; intracellular localization; enzymatic activity, inhibited NPM1(DISRUPTS); NCL(INDUCES) 17215513; 25233213 2 0 0 S139E mutant associates with nucleolin (but not with NPM1); tRNA modifying activities are suppressed by phosphorylation; ; reduced in nocodazole-treated cells; S139A mutant (but not S139E mutant) associates with NPM1 (but not with nucleolin) in mitotic cells; dephosphorylated forms of both methyltransferases is able to suppress 5-FU sensitivity; phosphorylation of NSUN2 S139 induces dissociation of NPM1 from the NSUN2/nucleolin complex +NCOA3 SRC-3 ACETYLTRANSFERASE; Acetyltransferase; EC 2.3.1.48; Motility/polarity/chemotaxis; Nuclear receptor co-regulator; Transcription, coactivator/corepressor Q9Y6Q9 8202 20q13.12 human K619-ac 460609 PLESKGHkKLLQLLT SRC-1 molecular association, regulation transcription, inhibited ER-alpha(DISRUPTS) 10490106 1 0 0 +BCAR1 P130Cas Adaptor/scaffold; Motility/polarity/chemotaxis P56945 9564 16q23.1 human Y327-p 448780 PLLREETyDVPPAFA molecular association, regulation; acetylation DNA repair, induced; transcription, induced RBBP4(INDUCES) DNA(INDUCES) 37182100 2 19 195 induces H4K16 acetylation +Tp53 p53 Activator; DNA-binding; Motility/polarity/chemotaxis; Nuclear receptor co-regulator; Transcription factor; Tumor suppressor P02340 22059 11 B3|11 42.83 cM mouse K367-ub 464661 RAHSSYLkTKKGQST transcription, altered 15964796 9 1 0 p53K6R (K378/383/369/379/367/370/R) mutant is still ubiquitinated and shows normal stability of p53 before and after DNA damage +DPYSL2 CRMP-2 iso3 Microtubule-binding; Motility/polarity/chemotaxis NP_001184222 1808 8p21.2 human S27-p 23053573 FKNLGSGsPKPRQKF protein degradation; protein stabilization; molecular association, regulation cell growth, induced PIN1(INDUCES) 26489457 1 9 1 axon growth in vitro +HPCAL1 HPCAL1 Calcium-binding P37235 3241 2p25.1 human T149-p 1876861206 ESTPEKRtDKIFRQM EF-hand_7 carcinogenesis, inhibited; autophagy, induced; cell growth, inhibited 35403545 1 0 0 +HTT Huntingtin Cytoskeletal P42858 3064 4p16.3 human K9-sm 8545503 ATLEKLMkAFESLKS protein stabilization; intracellular localization transcription, inhibited 15064418 2 0 0 +BAIAP2L1 IRTKS Adaptor/scaffold; Cytoskeletal Q9UHR4 55971 7q21.3-q22.1 human Y439-p 462517 VVIPPPDyLECLSMG cell motility, induced 21840312 1 0 3 +RET Ret EC 2.7.10.1; KINASE; Kinase, protein; Membrane protein, integral; Oncoprotein; Protein kinase, TK; Protein kinase, tyrosine (receptor) P07949 5979 10q11.21 human Y864-p 447626 QISQGMQyLAEMKLV PK_Tyr_Ser-Thr enzymatic activity, induced cell growth, altered 8637703 1 0 0 +ITGB2 ITGB2 Cell adhesion; Cell surface; Membrane protein, integral; Motility/polarity/chemotaxis; Receptor, misc. P05107 3689 21q22.3 human T758-p 448533 NPLFKSAtTTVMNPK Integrin_b_cyt molecular association, regulation; phosphorylation cell motility, induced; cell adhesion, induced; cytoskeletal reorganization; cell adhesion, altered; signaling pathway regulation 14-3-3 beta(INDUCES); FLNA(DISRUPTS); ACTN1(INDUCES); 14-3-3 zeta(INDUCES); kindlin-3(INDUCES) 11700305; 16301335; 17107954; 18550856; 23823319; 25278023; 29903913 8 2 3 +Snph syntaphilin iso4 Membrane protein, integral; Vesicle AAI39793 241727 2|2 G3 mouse S71-p 451012 PPLTRTRsLMAMSLQ molecular association, regulation STX1A(DISRUPTS) 14985338 1 0 0 +DUSP1 DUSP1 EC 3.1.3.16; EC 3.1.3.48; Motility/polarity/chemotaxis; PHOSPHATASE; Protein phosphatase, dual-specificity P28562 1843 5q35.1 human S323-p 457718 HCSAEAGsPAMAVLD protein degradation; molecular association, regulation SKP2(INDUCES) 16286470 1 0 0 MKP-1 is a substrate for Skp2 ligase +CRTC1 TORC1 Transcription factor Q6UUV9 23373 19p13.11 human S151-p 481986 TSWRRTNsDSALHQS TORC_M intracellular localization 20010869 7 17 5 Nuclear export +FEN1 FEN1 DNA repair, damage; DNA-binding; Deoxyribonuclease; EC 3.1.-.-; Nuclear receptor co-regulator; Nucleolus; Ribonuclease P39748 2237 11q12.2 human K375-ac 458856 AKTGAAGkFKRGK__ molecular association, regulation; enzymatic activity, inhibited DNA(DISRUPTS) 11430825 1 3 34 +HSF1 HSF1 DNA-binding; Transcription factor Q00613 3297 8q24.3 human S314-p 455482 SPRVEEAsPGRPSSV Vert_HS_TF transcription, inhibited 25963659 4 32 12 under non-stressed conditions, upon heat shock S to A mutant showed 60% higher luciferase activity +Pde3b PDE3B EC 3.1.4.17; Membrane protein, integral; Membrane protein, multi-pass; Nucleotide Metabolism - purine; Phosphodiesterase Q61409 18576 7 F1|7 59.46 cM mouse S273-p 447699 VIRPRRRsSCVSLGE enzymatic activity, induced 10454575 4 7 78 +Crtc2 TORC2 Transcription, coactivator/corepressor Q3U182 74343 3|3 F1 mouse S70-p 454630 RSSHYGGsLPNVNQI TORC_N molecular association, regulation; intracellular localization transcription, altered 14-3-3 beta(INDUCES) 18323454 1 30 33 +Cckar CCKAR GPCR, family 1; Membrane protein, integral; Membrane protein, multi-pass; Receptor, GPCR P30551 24889 14q11 rat S264-p 451124 FDASQKKsAKEKKPS 7tm_1 receptor desensitization, altered 11078715; 9203622 2 0 0 Constructs modifying S264 delayed the onset of desensitization. +MAP3K5 ASK1 EC 2.7.11.25; KINASE; Kinase, protein; Protein kinase, STE; Protein kinase, Ser/Thr (non-receptor) Q99683 4217 6q23.3 human T838-p 448394 GINPCTEtFTGTLQY Pkinase molecular association, regulation; phosphorylation; enzymatic activity, induced cell cycle regulation; carcinogenesis, induced; apoptosis, altered; apoptosis, induced; cell adhesion, altered; transcription, altered TXN(DISRUPTS); 14-3-3 beta(DISRUPTS) 17671211; 17937911; 25633196; 28888991; 33399853 20 2 1 Regulates invadosome formation +FOXA1 FOXA1 DNA-binding; Transcription factor P55317 3169 14q21.1 human K264-ac 11263048 GCYLRRQkRFKCEKQ molecular association, regulation chromatin organization, altered DNA(DISRUPTS) 19897491 1 0 0 +CERS2 LASS2 DNA-binding; Membrane protein, integral; Membrane protein, multi-pass; Transferase Q96G23 29956 1q21.3 human S341-p 470692 KLVEDERsDREETES enzymatic activity, induced 26887952 1 47 217 +STAT5B STAT5B DNA-binding; Oncoprotein; Transcription factor P51692 6777 17q21.2 human Y740-p 448735 AVCPQAHyNMYPQNP activity, inhibited transcription, altered; transcription, inhibited 16772534; 17822672 4 0 0 transcriptional activation of STAT5B Y740/743 mutant requires phosphorylation of S731 and Y699 +DES desmin Cytoskeletal; Motility/polarity/chemotaxis P17661 1674 2q35 human S32-p 466343 PLGSPLSsPVFPRAG Filament_head protein conformation 29483093 4 13 31 formation of desmin-positive aggregates, decreased Z-bands incorporation +RBL2 Rb-like 2 Transcription, coactivator/corepressor; Tumor suppressor Q08999 5934 16q12.2 human T417-p 449725 KENSPCVtPVSTATH RB_A molecular association, regulation cell cycle regulation E2F4(DISRUPTS) 11157749 2 16 3 +IQGAP1 IQGAP1 GAP; GAP, Ras; Motility/polarity/chemotaxis P46940 8826 15q26.1 human K1230-ub 22246214 RNLGSIAkMLQHAAS RasGAP molecular association, regulation CDC42(INDUCES); RAC1(INDUCES) 32094223 1 4 0 6KR mutant compared to WT; no effect of K1155R or K1230R mutants on CDC42 or Rac binding +Ppargc1b PGC-1 beta Nuclear receptor co-regulator; Transcription, coactivator/corepressor Q8VHJ7 170826 18|18 E1 mouse K674-ac 7761210 PVSQAGQkRPFSCSF intracellular localization transcription, inhibited 19491097 1 1 0 +Etv1 ETV1 DNA-binding; Oncoprotein; Transcription factor P41164 14009 12 A3|12 17.99 cM mouse S146-p 3059603 TPSSTPVsPLHHASP ETS_PEA3_N activity, induced transcription, induced; signaling pathway regulation 22586091 2 1 0 +ILF2 ILF2 Nucleolus; RNA-binding; Transcription, coactivator/corepressor Q12905 3608 1q21.3 human K45-ub 12287558 EMAFPRVkPAPDETS protein degradation 33009960 1 10 40 +Tjp1 ZO1 Adaptor/scaffold; Motility/polarity/chemotaxis P39447 21872 7 C|7 35.02 cM mouse S168-p 470469 ASRERSLsPRSDRRS cytoskeletal reorganization 23967087 2 16 11 necessary for cytokinesis +AKTIP AKTIP Apoptosis; Membrane protein, peripheral; Vesicle Q9H8T0 64400 16q12.2 human S237-p 1876861202 IEDPYAIsFSPWNPS phosphorylation carcinogenesis, induced; cell growth, induced 35366279 1 1 0 +TERF2 TRF2 DNA repair, damage; DNA-binding Q15554 7014 16q22.1 human R55-me 10338215 GSSDGSGrAAGRRAS cell cycle regulation; cell growth, altered 19596784 1 0 0 +Sstr2 SSTR2 GPCR, family 1; Membrane protein, integral; Membrane protein, multi-pass; Receptor, GPCR P30875 20606 11 E2|11 79.05 cM mouse Y228-p 450819 LTIICLCyLFIIIKV 7tm_1; TM molecular association, regulation SHP-2(INDUCES) 12972574 1 0 0 +Creb1 CREB iso1 DNA-binding; Transcription factor P15337-1 81646 9q32 rat K94-ac 459098 QSSCKDLkRLFSGTQ transcription, inhibited 12595525 1 0 0 modulating CREB-mediated gene expression +Pias1 PIAS1 EC 6.3.2.-; Nuclear receptor co-regulator; SUMO LIGASE; SUMO conjugating system; SUMO ligase; Transcription, coactivator/corepressor O88907 56469 9|9 B mouse S90-p 479880 SPMPPTLsPSTIPQL transcription, inhibited 17540171 1 1 0 ; phosphorylation of this site inhibits TNF-induced expression of NFKB-target genes and IFN-induced expression of STAT1-target genes +Tnp2 TP2 DNA-binding P11101 24840 10q11 rat S109-p 450902 HRAKRRSsGRRYK__ TP2 intracellular localization 14514679 1 0 0 +LRRK1 LRRK1 EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, Ser/Thr (non-receptor); Protein kinase, TKL Q38SD2 79705 15q26.3 human S1817-p 41694201 GDSIADVsIMYSEEL molecular association, regulation; enzymatic activity, induced cytoskeletal reorganization WDR34(INDUCES); WDR60(INDUCES) 26192437; 36254578 2 0 0 +Stk11 LKB1 Autophagy; EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, CAMK; Protein kinase, Ser/Thr (non-receptor); Tumor suppressor Q9WTK7 20869 10|10 C1 mouse T336-p 448150 KDRWRSMtVVPYLED activity, inhibited cell growth, altered 11853558 2 0 0 +IGF1R IGF1R EC 2.7.10.1; KINASE; Kinase, protein; Membrane protein, integral; Protein kinase, TK; Protein kinase, tyrosine (receptor) P08069 3480 15q26.3 human S1310-p 2091903 VPLDPSAsSSSLPLP activity, induced; phosphorylation cell differentiation, altered; apoptosis, altered; cell growth, altered 10746631; 10786694 2 0 0 observed in Y980F + S1310-1313A; ERK phosphorylation +ATF4 ATF-4 DNA-binding; Transcription factor P18848 468 22q13.1 human T107-p 40420006 LGIDDLEtMPDDLLT protein degradation transcription, inhibited 25795775 1 1 0 +SMAD4 SMAD4 DNA-binding; Nuclear receptor co-regulator; Transcription, coactivator/corepressor Q13485 4089 18q21.2 human Y195-p 1881244700 NRASTETySTPALLA molecular association, regulation cell cycle regulation; carcinogenesis, induced; cell growth, induced; transcription, inhibited p300(DISRUPTS); CBP(DISRUPTS); H3(DISRUPTS) 36959211 1 1 0 binding to p300 promotes p300 binding to DNA +GLE1 GLE1 Karyopherin; Nuclear export Q53GS7 2733 9q34.11 human S99-p 18010022 SSAFSPAsPATPNGT molecular association, regulation GLE1(INDUCES) 30429220 1 10 0 self-association stress granules' assembly and disassembly, DDX3-ATPase activity inhibited +ITGB4 ITGB4 iso2 Cell adhesion; Membrane protein, integral; Motility/polarity/chemotaxis; Receptor, misc. P16144-2 3691 17q25.1 human S1424-p 465821 TLTRDYNsLTRSEHS intracellular localization carcinogenesis, induced 22824799 2 14 31 decreased phosphorylation of this site and cells invasion of CD151-depleted A431 cells +LMO7 LMO7 iso3 Adaptor/scaffold Q8WWI1-3 4008 13q22.2 human S863-p 478135 LKNLKRRsQFFEQGS molecular association, regulation; phosphorylation carcinogenesis, inhibited; cell growth, inhibited; transcription, induced; signaling pathway regulation STING(INDUCES) 33767426 1 12 39 binding to STING induces STING-TBK1 binding and TBK1 autophosphorylation, regulates STING?IFN-? pathway +Dusp4 DUSP4 EC 3.1.3.16; EC 3.1.3.48; PHOSPHATASE; Protein phosphatase, dual-specificity Q8BFV3 319520 8|8 A4 mouse T363-p 15412237 ERGKATPtPTSQFVF protein stabilization 22430215 1 0 1 +Ndel1 NDEL1 Microtubule-binding; Protease Q9ERR1 83431 11|11 B3 mouse S231-p 474507 GTENSFPsPKAIPNG NUDE_C activity, induced; intracellular localization cell motility, altered 18331715 5 18 0 Cdc42 activation +Crebbp CBP ACETYLTRANSFERASE; Acetyltransferase; DNA-binding; EC 2.3.1.48; Motility/polarity/chemotaxis; Nuclear receptor co-regulator; Transcription, coactivator/corepressor P45481 12914 16 A1|16 2.4 cM mouse S301-p 448068 PQLASKQsMVNSLPA transcription, induced 11970865 1 0 0 +TGFBR2 TGFBR2 EC 2.7.11.30; KINASE; Kinase, protein; Membrane protein, integral; Oncoprotein; Protein kinase, Ser/Thr (receptor); Protein kinase, TKL P37173 7048 3p24.1 human S213-p 452047 TRKLMEFsEHCAIIL cell growth, altered 9155023 1 0 0 +MTHFR MTHFR Cofactor and Vitamin Metabolism - one carbon pool by folate; EC 1.5.1.20; Energy Metabolism - methane; Oxidoreductase P42898 4524 1p36.22 human T34-p 456129 KDSSRCStPGLDPER molecular association, regulation; enzymatic activity, inhibited; activity, inhibited PLK1(INDUCES) 16024724; 24769206; 28820331 3 2 2 +RB1 Rb Nuclear receptor co-regulator; Oncoprotein; Transcription, coactivator/corepressor; Tumor suppressor P06400 5925 13q14.2 human K810-m2 34823404 NIYISPLkSPYKISE Rb_C molecular association, regulation cell cycle regulation; DNA repair, induced; carcinogenesis, inhibited; cell growth, inhibited PHF20L1(INDUCES); 53BP1(INDUCES) 25049398; 28841214 2 0 0 +ACLY ACLY Carbohydrate Metabolism - citrate (TCA) cycle; EC 2.3.3.8; Lyase; Transferase P53396 47 17q21.2 human K86-ac 11323415 DGVKSWLkPRLGQEA protein degradation; molecular association, regulation cell growth, altered ARHGEF3(INDUCES) 36241648 1 4 0 +AKAP12 AKAP12 Adaptor/scaffold Q02952 9590 6q25.1 human S772-p 34663200 LVTPRKKsKSKLEEK WSK receptor desensitization, inhibited; molecular association, regulation ADRB2(INDUCES) 14657015 1 1 0 +FLT3 FLT3 EC 2.7.10.1; KINASE; Kinase, protein; Membrane protein, integral; Oncoprotein; Protein kinase, TK; Protein kinase, tyrosine (receptor) P36888 2322 13q12.2 human Y597-p 450033 FYVDFREyEYDLKWE phosphorylation 11971190 2 0 0 however, in the FLT3-ITD mutant, there is only a slight decrease in its phosphotyrosine content and this mutation does not alter its transforming capabilities (and STAT5a and MAPK activation and SHC phosphorylation).; Mutation of all 4 sites from Y->F abrogates the phosphotyrosine content of wt-FLT3 +EEF2K EEF2K EC 2.7.11.20; KINASE; Kinase, protein; Protein kinase, Ser/Thr (non-receptor); Protein kinase, atypical; Translation O00418 29904 16p12.2 human S366-p 447827 SPQVRTLsGSRPPLL enzymatic activity, inhibited; phosphorylation; enzymatic activity, induced autophagy, inhibited; translation, induced 22216903; 23182879; 35841486 16 11 20 inhibits EEf2 phosphorylation +AKT1 Akt1 EC 2.7.11.1; KINASE; Kinase, protein; Oncoprotein; Protein kinase, AGC; Protein kinase, Ser/Thr (non-receptor) P31749 207 14q32.33 human T291-p 28706900 KDGHIKItDFGLCKE Pkinase signaling pathway regulation 23768697 0 1 0 PI3K-Akt-eNOS signaling pathway +MCL1 MCL1 Apoptosis; Channel, misc.; Inhibitor; Membrane protein, integral; Mitochondrial Q07820 4170 1q21.2 human S64-p 479431 IGGSAGAsPPSTLTP protein degradation; protein stabilization; molecular association, regulation; ubiquitination carcinogenesis, induced; apoptosis, induced; apoptosis, inhibited BIM(INDUCES); HUWE1(DISRUPTS); NOXA1(INDUCES) 17463001; 26219338; 27166195; 27738316; 36171331 8 6 0 +VAV1 VAV1 GEF; GEF, Rac/Rho; Motility/polarity/chemotaxis; Oncoprotein P15498 7409 19p13.3 human Y174-p 447866 EAEGDEIyEDLMRSE activity, induced; molecular association, regulation; intracellular localization; activity, inhibited cell differentiation, altered; cytoskeletal reorganization; transcription, inhibited; cell growth, altered PLCG1(INDUCES); Lck(INDUCES); PIK3R1(INDUCES) 10636924; 17050525; 24332539 22 2 0 extracellular matrix degradation, invadopodia formation through Cdc42 +RAB11FIP2 RAB11FIP2 Cytoskeletal Q7L804 22841 10q26.11 human S227-p 465674 QRLSSAHsMSDLSGS cell differentiation, altered; cytoskeletal reorganization 16775013; 22553350 3 17 0 regulates cell polarity, alters the composition of cellular junctions; important for formation of junctional complexes and cell polarity +Nrf1 NRF1 DNA-binding; Transcription factor Q9WU00 18181 6 A3.3|6 12.47 cM mouse S318-p 1883500600 SNPDGTVsLIQVGTG molecular association, regulation transcription, induced DNA(DISRUPTS) 37409632 1 0 0 +ATM ATM DNA repair, damage; EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, Ser/Thr (non-receptor); Protein kinase, atypical; Tumor suppressor Q13315 472 11q22.3 human S1988-p 62382602 SQSTTISsLSEKSKE enzymatic activity, inhibited; protein conformation cell cycle regulation; apoptosis, inhibited 27939942 1 0 0 +RPTOR Raptor Adaptor/scaffold Q8N122 57521 17q25.3 human S771-p 13251700 SASSTLGsPENEEHI activity, induced 21757713 2 1 0 mTORC1 activation +Rab29 RAB29 G protein; G protein, monomeric; G protein, monomeric, Rab Q63481 171122 13q13 rat S72-p 396518800 AGQERFTsMTRLYYR Ras molecular association, regulation 29223392 2 0 0 located at an interface that mediates binding with other interactors; modi?cation of morphology and distribution of the trans-Golgi +Ttll4 TTLL4 EC 6.-.-.-; Ligase Q80UG8 67534 1|1 C4 mouse S1136-p 36123708 KKSQAGLsPISRKTL enzymatic activity, induced 34084286 1 2 0 +NKX3-1 NKX3-1 DNA-binding; Transcription factor; Tumor suppressor Q99801 4824 8p21.2 human S186-p 7998431 TKRKQLSsELGDLEK protein stabilization 23129228 2 1 1 +GPBAR1 GPBAR1 GPCR, family 1; Membrane protein, integral; Membrane protein, multi-pass; Receptor, GPCR Q8TDU6 151306 2q35 human S324-p 1877729206 YHPSSQSsVDLDLN_ molecular association, regulation cell growth, induced; apoptosis, inhibited ARRB1(INDUCES) 35858343 0 1 0 +PAK1 PAK1 EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, STE; Protein kinase, Ser/Thr (non-receptor) Q13153 5058 11q13.5-q14.1 human K39-ub 56714904 GTLNHGSkPLPPNPE protein degradation 27302166 1 0 0 +DVL2 DVL2 Adaptor/scaffold; Motility/polarity/chemotaxis O14641 1856 17p13.1 human K54-ub 40724400 LQRPAGAkYFFKSMD DIX protein conformation 25907794 1 0 0 inhibits DVL2 polymerization by attenuating filament assembly +Itgb1 ITGB1 Cell adhesion; Cell surface; Membrane protein, integral; Motility/polarity/chemotaxis; Receptor, misc. P09055 16412 8|8 E2 mouse Y795-p 447711 TTVVNPKyEGK____ Integrin_b_cyt cell motility, altered; cell adhesion, altered 10891511; 11259684 7 13 211 +Aqp2 AQP2 Channel, misc.; Membrane protein, integral; Membrane protein, multi-pass; Transporter; Transporter, aquaporin family P56402 11827 15 F1|15 56.13 cM mouse S264-p 2238600 VELHSPQsLPRGSKA molecular association, regulation; intracellular localization 14-3-3 theta(INDUCES) 19966308; 26645691 20 8 0 +DAPK1 DAPK1 Apoptosis; Autophagy; EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, CAMK; Protein kinase, Ser/Thr (non-receptor) P53355 1612 9q21.33 human Y491-p 487484 CAAWHGYySVAKALC Ank_2 enzymatic activity, inhibited; protein conformation carcinogenesis, induced; cell motility, induced; cell adhesion, induced; apoptosis, inhibited 17803936 1 0 0 +TACC3 TACC3 Cell cycle regulation F1NCL7 422899 chicken S575-p 474537 ESALRKQsLYLKFDP molecular association, regulation cytoskeletal reorganization AP1B1(INDUCES) 26134678 12 15 43 stabilization of spindle microtubules +Map2 MAP2 iso3 Cytoskeletal; Motility/polarity/chemotaxis P15146-3 25595 9q32 rat K230-ac 62495501 EPIRRAGkSGTSTPT cytoskeletal reorganization 28002468 1 1 0 +Pim1 Pim1 EC 2.7.11.1; KINASE; Kinase, protein; Oncoprotein; Protein kinase, CAMK; Protein kinase, Ser/Thr (non-receptor) P06803 18712 17 A3.3|17 15.38 cM mouse Y218-p 451014 EWIRYHRyHGRSAAV Pkinase activity, induced 14981536 1 0 0 +Bcl2l1 Bcl-xL Apoptosis; Autophagy; Membrane protein, integral; Mitochondrial Q64373 12048 2 75.41 cM|2 H1 mouse S14-p 33668512 ELVVDFLsYKLSQKG BH4 molecular association, regulation apoptosis, induced; signaling pathway regulation BIM(INDUCES); BID(INDUCES); BAX(DISRUPTS) 24813943; 27218122 3 1 0 +RUNX1 AML1 DNA-binding; Oncoprotein; Transcription factor Q01196 861 21q22.12 human S276-p 454401 VHPATPIsPGRASGM molecular association, regulation transcription, induced HDAC1(INDUCES); SIN3A(INDUCES) 34673281 13 11 70 +NRIP1 RIP140 Nuclear receptor co-regulator; Transcription, coactivator/corepressor P48552 8204 21q11.2-q21.1 human R947-m1 2363400 LLSENCVrDLSPHRS NRIP1_repr_4 molecular association, regulation; intracellular localization transcription, induced Exportin-1(INDUCES) DNA(DISRUPTS) 17053781 2 2 0 +PLCG2 PLCG2 Carbohydrate Metabolism - inositol phosphate; EC 3.1.4.11; Motility/polarity/chemotaxis; Phospholipase P16885 5336 16q23.3 human S1164-p 25692906 AVKSGFRsVPLKNGY C2 signaling pathway regulation 22759789 1 0 0 B cell receptor signaling +NOXA1 NOXA1 Activator Q86UR1 10811 9q34.3 human S172-p 990300 DQVQRRGsLPPRQVP molecular association, regulation; intracellular localization; enzymatic activity, inhibited RAC1(DISRUPTS); 14-3-3 zeta(INDUCES); NOX1(DISRUPTS) 17913709; 20110267 2 0 0 regulates association with 14-3-3 and dissociation from Nox1, which in-turn inhibits Nox1 activity and production of ROS; prevents hyperactivation of NOX1 +LRP2 LRP2 Membrane protein, integral; Motility/polarity/chemotaxis; Receptor, misc. P98164 4036 2q31.1 human T4641-p 767907 TYSATEDtFKDTANL receptor internalization, altered; receptor recycling, altered 17555532 1 0 1 +SCN5A SCN5A Channel, sodium; Membrane protein, integral; Membrane protein, multi-pass Q14524 6331 3p22.2 human T670-p 40558327 LSAVSVLtSALEELE protein conformation 33410863 1 2 0 +HDAC2 HDAC2 DEACETYLASE; Deacetylase; EC 3.5.1.98; Nuclear receptor co-regulator; Transcription, coactivator/corepressor P56519 395635 chicken S411-p 13373500 KRISIRAsDKRIACD molecular association, regulation MBD3(DISRUPTS); HDAC2(INDUCES); MTA1(DISRUPTS) 33596269 3 3 0 promotes homodimerization +CIITA CIITA DNA-binding; EC 2.7.11.1; KINASE; Protein kinase, Ser/Thr (non-receptor); Transcription, coactivator/corepressor P33076 4261 16p13.13 human S280-p 471421 TVHGLPTsPDRPGST protein degradation; protein stabilization; molecular association, regulation; ubiquitination; intracellular localization transcription, induced CCNT1(INDUCES) 17095509; 26181363 3 0 0 MHC II transcription, global ubiquitination levels, CIITA nuclear mobilization +Map1b MAP1B Cytoskeletal; Motility/polarity/chemotaxis P14873 17755 13 D1|13 52.9 cM mouse T1265-p 455476 PPSPIEKtPLGERSV cytoskeletal reorganization 15731007 2 9 3 induces a loss of stable microtubules +LATS2 LATS2 EC 2.7.11.1; KINASE; Kinase, protein; Nuclear receptor co-regulator; Protein kinase, AGC; Protein kinase, Ser/Thr (non-receptor); Tumor suppressor Q9NRM7 26524 13q12.11 human S83-p 451703 ALREIRYsLLPFANE intracellular localization cell cycle regulation 15147269; 21788394 4 0 0 +MALT1 MALT1 Adaptor/scaffold; Apoptosis; EC 3.4.22.-; Ligase; Nuclear export; Protease; UBIQUITIN LIGASE; Ubiquitin conjugating system Q9UDY8 10892 18q21.32 human K724-ub 2134706 MHRGLGRkTCFQTCL protein degradation; molecular association, regulation IKKA(INDUCES) 17948050 1 0 0 activation of NF-kB pathway and IL-2 induction +SRSF1 SF2 RNA splicing; RNA-binding; Spliceosome Q07955 6426 17q22 human R109-m1 9291750 GGGGGAPrGRYGPPS intracellular localization RNA splicing, induced; RNA stability, inhibited; translation, induced 20308322 1 7 40 prevents SF2 nuclear import and splicing of target genes, and translation is increased in the cytoplasm +RPS6KB1 p70S6K iso2 EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, AGC; Protein kinase, Ser/Thr (non-receptor); Translation P23443-2 6198 17q23.1 human K484-ac 32640201 QPNSGPYkKQAFPMI molecular association, regulation; enzymatic activity, inhibited; phosphorylation transcription, inhibited Raptor(DISRUPTS) 24652283; 31028173 3 0 0 inhibits mesangial cell hypertrophy and expression of fibronectin and collagen I ; Sirt1,2 deacetylate p70S6K which enhances T389 phosphorylation and it's kinase activity +Ppp2r5d PPP2R5D Motility/polarity/chemotaxis; PHOSPHATASE; Protein phosphatase, regulatory subunit Q7TNL5 21770 17 22.9 cM|17 C mouse S68-p 457389 QLSKIKYsGGPQIVK enzymatic activity, induced 20106966 4 5 0 +Homer1 HOMER1 Adaptor/scaffold; Cell development/differentiation Q9Z2Y3 26556 13|13 C3 mouse S117-p 51633300 ARLAKEKsQEKMELT molecular association, regulation GluR5(DISRUPTS) 26670047 1 0 0 circuit hyperexcitability in fragile X syndrome +HMGN1 HMGN1 DNA-binding; Nuclear receptor co-regulator P05114 3150 21q22.2 human K14-ac 458842 SSAEGAAkEEPKRRS HMG14_17 molecular association, regulation DNA(DISRUPTS) 10753971 1 5 13 +Pah PAH Amino Acid Metabolism - phenylalanine, tyrosine and tryptophan biosynthesis; EC 1.14.16.1; Oxidoreductase P04176 24616 7q13 rat S16-p 449074 GVLSRKLsDFGQETS protein conformation 12142458; 23537590 7 7 36 +Wasf1 WAVE1 Cytoskeletal; Motility/polarity/chemotaxis Q8R5H6 83767 10 B1|10 22.07 cM mouse S397-p 7979603 APPLVQPsPPVARAA activity, inhibited 20403076 4 2 0 +LSM4 LSM4 RNA-binding; Spliceosome Q9Y4Z0 25804 19p13.11 human R88-m2 15381287 EEVVAKGrGRGGLQQ molecular association, regulation SMN(INDUCES) 11720283 1 2 1 +YAP1 YAP1 iso3 Oncoprotein; Transcription, coactivator/corepressor P46937-3 10413 11q22.1 human Y341-p 15565111 PFLNSGTyHSRDEST activity, induced; molecular association, regulation; intracellular localization carcinogenesis, induced; cell growth, induced; transcription, induced TEAD1(INDUCES) 27013234 6 4 3 +Acaca ACC1 Carbohydrate Metabolism - propanoate; Carbohydrate Metabolism - pyruvate; EC 6.3.4.14; EC 6.4.1.2; Ligase; Lipid Metabolism - fatty acid biosynthesis P11497 60581 10q26 rat S79-p 448292 FHMRSSMsGLHLVKQ enzymatic activity, inhibited 12015362; 1688796; 1967580; 7915280 166 76 11 +ERBB4 HER4 EC 2.7.10.1; KINASE; Kinase, protein; Membrane protein, integral; Protein kinase, TK; Protein kinase, tyrosine (receptor) Q15303 2066 2q34 human Y1268-p 4825104 EYSTKYFyKQNGRIR molecular association, regulation GRB2(INDUCES); NCK2(INDUCES) 16729043 1 1 0 +SNAI1 Snail1 C2H2-type zinc finger protein; Transcription factor O95863 6615 20q13.13 human K206-ub 231166702 VRTHTGEkPFSCPHC protein stabilization 28892081 1 0 0 metastasis +SP7 osterix C2H2-type zinc finger protein; DNA-binding; Transcription factor Q8TDD2 121340 12q13.13 human S80-p 15334101 GLLSPAGsPPAPTSG molecular association, regulation transcription, induced AML3(INDUCES) 25122769; 27498006 4 0 0 transcriptional activity on the Cx43 promoter +CDKN1C p57Kip2 Cell cycle regulation; Inhibitor; Nuclear receptor co-regulator; Tumor suppressor P49918 1028 11p15.4 human S282-p 9318134 FFAKRKRsAPEKSSG protein degradation 23421998 1 0 0 DN-Akt stabilized p57 +ITGB7 ITGB7 Cell adhesion; Membrane protein, integral; Motility/polarity/chemotaxis; Receptor, misc. P26010 3695 12q13.13 human T785-p 464649 YKSAITTtINPRFQE Integrin_b_cyt molecular association, regulation FLNA(DISRUPTS) 16455489 1 0 0 based on glutamate mutant of threonine site +Sirt1 SIRT1 Apoptosis; DEACETYLASE; Deacetylase; EC 3.5.1.-; Nuclear receptor co-regulator Q923E4 93759 10|10 B4 mouse S649-p 6855923 FHGAEVYsDSEDDVL enzymatic activity, induced apoptosis, inhibited 19680552 2 0 0 deacetylates p53 K382 and NFkB-p65 +FERMT2 kindlin-2 Cytoskeletal; Motility/polarity/chemotaxis Q96AC1 10979 14q22.1 human K154-ub 964523622 PTKKKKKkLDDQSED protein degradation cell adhesion, inhibited 28408404 1 1 0 +Nr2c2 NR2C2 DNA-binding; Nuclear receptor; Transcription factor P49117 22026 6|6 D1 mouse S68-p 467310 TGKVILAsPETSSAK activity, inhibited transcription, altered 16887930 1 14 0 +Havcr2 TIM-3 Membrane protein, integral; Receptor, misc. Q8VIM0 171285 11|11 B1.1 mouse Y263-p 26371002 YTIEENVyEVENSNE molecular association, regulation BAT3(DISRUPTS) 22863785 4 0 0 +Sh3gl1 endophilin A2 Oncoprotein; Vesicle Q62419 20405 17 D|17 29.11 cM mouse Y315-p 450745 QPSCKALyDFEPEND SH3_1 carcinogenesis, induced; cell motility, induced; transcription, altered; endocytosis, inhibited 23255596 2 2 3 induces surface expression of MT1-MMP by inhibiting its endocytosis +CEBPA C/EBP-alpha DNA-binding; Transcription factor P49715 1050 19q13.11 human S190-p 457552 PPPPPPPsHPHPHPP protein degradation; molecular association, regulation carcinogenesis, inhibited; cell growth, inhibited; cell differentiation, induced; transcription, induced HDAC1(DISRUPTS); PSMD10(INDUCES) 29159818; 34245919 2 0 0 +Trp53 p53 iso2 Activator; DNA-binding; Motility/polarity/chemotaxis; Nuclear receptor co-regulator; Transcription factor; Tumor suppressor Q80ZA1 22059 11 B3|11 42.83 cM mouse K161-ac 2793003 VRAMAIYkKSQHMTE P53 transcription, induced 27705786 12 1 0 +GLUL GLUL Amino Acid Metabolism - alanine, aspartate and glutamate; Amino Acid Metabolism - arginine and proline; EC 4.1.1.15; EC 6.3.1.2; Energy Metabolism - nitrogen; Ligase P15104 2752 1q25.3 human K11-ac 55588404 SASSHLNkGIKQVYM protein degradation; molecular association, regulation; ubiquitination CRBN(INDUCES) 26990986 1 1 0 +Rxra RXRA DNA-binding; Motility/polarity/chemotaxis; Nuclear receptor P28700 20181 2 A3|2 19.38 cM mouse S22-p 453093 VNSSSLNsPTGRGSM Nuc_recep-AF1 cell cycle regulation; transcription, altered; cell growth, altered 12032153 4 12 4 +S100A9 S100A9 Calcium-binding; Cell development/differentiation; Motility/polarity/chemotaxis P06702 6280 1q21.3 human T113-p 455888 KPGLGEGtP______ activity, induced; intracellular localization cytoskeletal reorganization 15905572; 17429438 4 14 22 +NOS3 eNOS Amino Acid Metabolism - arginine and proline; EC 1.14.13.39; Oxidoreductase P29473 287024 cow S617-p 448656 SYKIRFNsVSCSDPL Flavodoxin_1 molecular association, regulation; enzymatic activity, induced; phosphorylation HSP90A(DISRUPTS); Akt1(DISRUPTS) 12591925; 16257964; 19251696 13 5 0 +SH3BP2 SH3BP2 Adaptor/scaffold P78314 6452 4p16.3 human Y448-p 449093 GDDSDEDyEKVPLPN molecular association, regulation transcription, altered Lck(INDUCES) 15751964 5 0 0 +H3F3C H3 DNA-binding P84229 427887 chicken K27-m3 1308913 LATKAARkSAPATGG Histone chromatin organization, altered; transcription, inhibited 23028147 195 24 3 +Adcy6 ADCY6 Adenylyl cyclase; EC 4.6.1.1; Lyase; Membrane protein, integral; Membrane protein, multi-pass; Nucleotide Metabolism - purine; Transporter; Transporter, aquaporin family AAA40678 25289 7q36 rat S10-p 450817 LPVARSGsGRSSMSW enzymatic activity, inhibited 11877398 2 0 0 +Cyth3 cytohesin 3 GEF; GEF, ARF; Lipid-binding; Nuclear receptor co-regulator; Receptor, misc. O08967 19159 5 G2|5 82.36 cM mouse S155-p 25585001 ALRQFLWsFRLPGEA Sec7 receptor recycling, induced 22609160 1 0 0 Glut4 vesicle formation +MAP3K7 TAK1 EC 2.7.11.25; KINASE; Kinase, protein; Protein kinase, Ser/Thr (non-receptor); Protein kinase, TKL O43318 6885 6q15 human K209-ub 11956706 EGSNYSEkCDVFSWG PK_Tyr_Ser-Thr protein stabilization; molecular association, regulation; phosphorylation apoptosis, induced; signaling pathway regulation MEKK3(INDUCES) 19843958; 23770285 3 0 0 induces stabilization of Traf6-MEKK3-TAK1 complex, regulates IL1 -induced NF-kB activation pathway; autophosphorylation of TAK1, and activation of JNK and p38 +TRPC3 TRPC3 Channel, cation; Membrane protein, integral; Membrane protein, multi-pass Q13507 7222 4q27 human Y299-p 458805 KGLASPAyLSLSSED activity, induced 16407161 1 0 0 +Cd28 CD28 Cell surface; Membrane protein, integral P31041 12487 1 C2|1 30.52 cM mouse Y207-p 450284 TRKPYQPyAPARDFA activity, induced; molecular association, regulation Lck(INDUCES) 27460989; 9973466 7 8 276 Y207F mutation severely impaired the ability of CD28 to deliver a co-stimulus for the expression of CD69 and production of IL-2. +INSR INSR EC 2.7.10.1; KINASE; Kinase, protein; Membrane protein, integral; Protein kinase, TK; Protein kinase, tyrosine (receptor) P06213 3643 19p13.2 human S1062-p 451562 AVKTVNEsASLRERI PK_Tyr_Ser-Thr phosphorylation 10819237 3 0 1 alanine mutations of S1033, S1062, and S1064 increases tyrosine autophosphorylation of InsR +Pln PLB Inhibitor; Membrane protein, integral P61014 18821 10|10 B3 mouse K3-ub 27204320 _____MEkVQYLTRS Phospholamban ubiquitination 26966065 1 1 0 +TAOK2 TAO2 Apoptosis; EC 2.7.11.1; KINASE; Kinase, protein; Membrane protein, integral; Membrane protein, multi-pass; Protein kinase, STE; Protein kinase, Ser/Thr (non-receptor) Q9UL54 9344 16p11.2 human T468-p 23150863 RNRDHFAtIRTASLV cytoskeletal reorganization 25456499 1 1 1 spine development +YBX1 YB-1 RNA processing; RNA splicing; RNA-binding; Transcription factor P67809 4904 1p34.2 human S102-p 455636 NPRKYLRsVGDGETV CSD activity, induced; molecular association, regulation; protein stabilization; ubiquitination; intracellular localization carcinogenesis, induced; carcinogenesis, altered; cell motility, induced; transcription, induced; signaling pathway regulation; transcription, altered; translation, altered; cell growth, induced; cytoskeletal reorganization; translation, induced; transcription, inhibited; cell growth, altered KLF5(INDUCES) 15806160; 17704806; 19036157; 20844753; 21423216; 27591085; 31387591; 31906126; 32028981; 33379356; 33911076; 34272387; 35008856; 35022570; 35917517 23 33 2 +NFATC4 NFAT3 DNA-binding; Transcription factor Q14934 4776 14q12 human S168-p 448859 QGGGAFFsPSPGSSS intracellular localization; activity, inhibited cell differentiation, altered; transcription, altered; cell growth, altered 11997522; 17213202 7 0 1 +MDM2 MDM2 EC 6.3.2.-; EC 6.3.2.19; Inhibitor; Ligase; NEDDYLATION LIGASE; Neddylation Ligase; Nucleolus; Oncoprotein; UBIQUITIN LIGASE; Ubiquitin conjugating system; Ubiquitin ligase Q00987 4193 12q15 human S186-p 448131 RQRKRHKsDSISLSF activity, induced; protein degradation; protein stabilization; molecular association, regulation; ubiquitination; intracellular localization apoptosis, altered; signaling pathway regulation ER-beta(INDUCES); p300(INDUCES); ARF1(INDUCES); AR(INDUCES); CBP(INDUCES) 11504915; 11715018; 11923280; 18467333; 22349818; 22525275; 23132866; 28196907 14 9 2 +CTTN Cortactin Actin-binding; Cytoskeletal; Motility/polarity/chemotaxis Q14247 2017 11q13.3 human K309-ac 461724 YSKGFGGkYGVQKDR HS1_rep molecular association, regulation; intracellular localization cell motility, inhibited ACTB(DISRUPTS) 17643370 2 4 20 Acetylation prevents localization to membrane ruf?es. +PDE4D PDE4D iso5 EC 3.1.4.53; Nucleotide Metabolism - purine; Phosphodiesterase Q08499-5 5144 5q11.2-q12.1 human S413-p 451090 YQSTIPQsPSPAPDD enzymatic activity, inhibited 10828059 7 3 0 +PIN1 PIN1 EC 5.2.1.8; Isomerase; Nuclear receptor co-regulator Q13526 5300 19p13.2 human S71-p 18710000 HSQSRRPsSWRQEKI Rotamase protein degradation; molecular association, regulation; ubiquitination; intracellular localization; enzymatic activity, inhibited; activity, inhibited cell cycle regulation; carcinogenesis, inhibited; cell motility, inhibited; transcription, inhibited CPEB(INDUCES) 21497122; 23090969; 26387736 6 1 0 Pin1 induces CPEB ubiquitination and degradation. ; inhibits nuclear localization and centrosome amplification +Nudt14 NUDT14 EC 3.6.1.45; Hydrolase Q9D142 66174 12|12 F1 mouse T141-p 41294000 TDLRRVAtYMSGVGL NUDIX enzymatic activity, induced 26048992 1 0 0 +Tiam1 TIAM1 GEF; GEF, Rac/Rho; Motility/polarity/chemotaxis; Oncoprotein Q60610 21844 16 C3.3|16 51.5 cM mouse S172-p 11485306 FKKKRSKsADIWRED molecular association, regulation 14-3-3 zeta(INDUCES) 19899799 2 4 0 +PRKAA1 AMPKA1 Autophagy; EC 2.7.11.1; EC 2.7.11.26; EC 2.7.11.27; EC 2.7.11.31; KINASE; Kinase, protein; Protein kinase, CAMK; Protein kinase, Ser/Thr (non-receptor) Q13131 5562 5p13.1 human S496-p 450431 ATPQRSGsVSNYRSC AdenylateSensor enzymatic activity, inhibited 27784766 19 46 55 +ZC3HC1 NIPA Cell cycle regulation; Ubiquitin conjugating system Q86WB0 51530 7q32.2 human S344-p 468306 GSEQAEKsPGPIVSR Rsm1 molecular association, regulation; intracellular localization cell growth, induced NPM-ALK(DISRUPTS) 31434245 1 66 16 +XRCC1 XRCC1 DNA repair, damage P18887 7515 19q13.31 human T523-p 451448 AGSTDENtDSEEHQE molecular association, regulation; intracellular localization PARP1(DISRUPTS); APTX(INDUCES); Pnk1(INDUCES) 15066279; 15367657; 25477519 4 5 3 +HIPK2 HIPK2 EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, CMGC; Protein kinase, Ser/Thr (non-receptor) Q9H2X6 28996 7q34 human K803-ub 3059905 TSTTSSRkSKQHQSS protein degradation 18536714 1 0 0 +Med1 MED1 Nuclear receptor co-regulator; Transcription, coactivator/corepressor Q925J9 19014 11 D|11 61.75 cM mouse T1459-p 449866 HSKSPAYtPQNVDSE transcription, induced 18339625 7 2 0 +Rprd1b RPRD1B Motility/polarity/chemotaxis Q9CSU0 70470 2|2 H1 mouse S145-p 10404515 KAAEEKKsLKRTFQQ molecular association, regulation cell cycle regulation; carcinogenesis, induced; cell growth, induced; transcription, induced; cytoskeletal reorganization AurB(INDUCES) 30518842 1 1 2 regulate the expression of cyclin B1 in gastric cancer +NFATC1 NFAT2 DNA-binding; Transcription factor O95644 4772 18q23 human T154-p 1869090801 SSKRSPStATLSLPS activity, induced carcinogenesis, induced; cell motility, induced; transcription, induced 31730483 1 1 0 multiple sites mutatnt +GRK2 GRK2 EC 2.7.11.15; KINASE; Kinase, protein; Protein kinase, AGC; Protein kinase, Ser/Thr (non-receptor) P25098 156 11q13.2 human K220-ub 573762722 TGKMYAMkCLDKKRI Pkinase acetylation; phosphorylation cell motility, induced; cell adhesion, induced; cytoskeletal reorganization 22193721 1 2 0 induces deacetylation of TUBA1A at K40 via HDAC6 phosphorylation +Btk Btk EC 2.7.10.2; KINASE; Kinase, protein; Protein kinase, TK; Protein kinase, tyrosine (non-receptor) P35991 12229 X E3|X 56.18 cM mouse S21-p 463806 SQQKKKTsPLNFKKR PH molecular association, regulation PIN1(INDUCES) 16644721 1 1 2 Interaction with Pin1 negatively regulates Btk expression. +Gja1 GJA1 Channel, misc.; Membrane protein, integral; Membrane protein, multi-pass; Motility/polarity/chemotaxis P23242 14609 10 B4|10 28.64 cM mouse S368-p 447813 QRPSSRAsSRASSRP protein degradation; protein stabilization; ubiquitination endocytosis, induced 24498049; 24612377 57 8 1 +SMAD7 SMAD7 DNA-binding; Transcription factor O15105 4092 18q21.1 human R57-m2 1881315000 AGGGGPGrAGCCLGK activity, induced; molecular association, regulation carcinogenesis, induced; cell growth, induced; transcription, induced; signaling pathway regulation gp130(INDUCES) 34026434 1 1 0 STAT3 activation, STAT3 signaling, PRMT5 promotes lung tumorigenesis +SLC12A1 NKCC2 Membrane protein, integral; Membrane protein, multi-pass; Transporter; Transporter, SLC family Q13621 6557 15q21.1 human S130-p 478420 GPKVNRPsLLEIHEQ AA_permease_N activity, induced signaling pathway regulation 21321328 8 2 0 WNK-SPAK-OSR1 pathway +MAPT Tau iso8 ACETYLTRANSFERASE; Acetyltransferase; Cytoskeletal P10636-8 4137 17q21.31 human S262-p 447930 NVKSKIGsTENLKHQ Tubulin-binding O-GlcNAc glycosylation; protein stabilization; molecular association, regulation; intracellular localization; protein conformation; phosphorylation apoptosis, altered; cell growth, inhibited; apoptosis, induced; autophagy, inhibited; transcription, induced; cytoskeletal reorganization TUBA1A(DISRUPTS); TUBA4A(DISRUPTS); Tau iso8(INDUCES); TUBB(DISRUPTS); TUBA1A(INDUCES) 10090741; 15190058; 15652175; 15664690; 17045592; 18424437; 19451179; 20159774; 20466736; 20663882; 21204788; 23001711; 24618580; 33710538; 33967735; 34936879; 36003083; 36004506; 7706316; 9735171 118 25 2 +MPZL1 PZR Adaptor/scaffold; Membrane protein, integral O95297 9019 1q24.2 human Y263-p 449521 NKSESVVyADIRKN_ molecular association, regulation cell adhesion, altered SHP-2(INDUCES) 11751924 1 57 1101 +Pfn2 profilin 2 Actin-binding; Motility/polarity/chemotaxis Q9EPC6 81531 2q26 rat S138-p 35541800 MAKYLRDsGF_____ Profilin cytoskeletal reorganization 21920940 2 0 0 S138A mutant enhances, and S138D mutant inhibits, neurite extension in PC12 cells +Th TH Amino Acid Metabolism - tyrosine; EC 1.14.16.2; Endoplasmic reticulum; Mitochondrial; Oxidoreductase; Vesicle P24529 21823 7 F5|7 88.06 cM mouse S19-p 448542 KGFRRAVsEQDTKQA TOH_N phosphorylation neural plasticity 20356833; 32358047 46 9 4 IRL790-induced neurotransmission; SNCA S129A mutant has higher PPP2CA activation inhibiting TH S19 phosphorylation. +HBP1 HBP1 DNA-binding; Transcription factor O60381 26959 7q22.3 human S402-p 455671 GFSKNCGsPGSSQLS protein stabilization 14612426 1 6 0 +ADRB2 ADRB2 GPCR, family 1; Membrane protein, integral; Membrane protein, multi-pass; Receptor, GPCR P07550 154 5q32 human S346-p 447911 LLCLRRSsLKAYGNG receptor desensitization, inhibited; receptor recycling, inhibited; receptor desensitization, altered; intracellular localization; receptor internalization, altered cytoskeletal reorganization 11146000; 11809767; 24003153; 27646272; 9461522 12 3 0 +NFKBIA IkB-alpha DNA-binding; Inhibitor P25963 4792 14q13.2 human S293-p 451525 EESYDTEsEFTEFTE protein degradation 10764587 3 0 0 +HNF4A HNF4 alpha DNA-binding; Nuclear receptor; Transcription factor P41235 3172 20q13.12 human S313-p 449926 GKIKRLRsQVQVSLE Hormone_recep protein degradation transcription, inhibited 12740371; 28196117 5 3 0 +HSP90AA1 HSP90A Chaperone; Heat shock protein P07900 3320 14q32.31 human K191-sm 31843000 TKVILHLkEDQTEYL HATPase_c molecular association, regulation AHSA1(INDUCES) 24462205 1 0 0 inhibits chaperone function +MAP3K11 MLK3 EC 2.7.11.25; KINASE; Kinase, protein; Protein kinase, Ser/Thr (non-receptor); Protein kinase, TKL Q16584 4296 11q13.1 human S758-p 448611 GTPGTPRsPPLGLIS molecular association, regulation BRAF(DISRUPTS) 29084209 3 14 0 oxidative stress-induced invasion of colon cancer cells; promotes MLK3-dependent B-Raf and ERK1/2 activation +CASR CaR GPCR, family 3; Membrane protein, integral; Membrane protein, multi-pass; Motility/polarity/chemotaxis; Receptor, GPCR P41180 846 3q13.33-q21.1 human S875-p 4782110 TIEEVRCsTAAHAFK activity, inhibited signaling pathway regulation 31189667 1 2 0 regulates Ca2+ sensitivity +Ctnnb1 CTNNB1 Actin-binding; Cell adhesion; Motility/polarity/chemotaxis; Nuclear receptor co-regulator; Oncoprotein; Transcription factor Q9WU82 84353 8q32 rat S33-p 447487 QQQSYLDsGIHSGAT protein degradation; intracellular localization; phosphorylation cytoskeletal reorganization 14985333; 17260019 112 3 2 +Plcg1 PLCG1 Carbohydrate Metabolism - inositol phosphate; EC 3.1.4.11; Motility/polarity/chemotaxis; Phospholipase P10686 25738 3q42 rat Y1253-p 448576 EGSFEARyQQPFEDF enzymatic activity, induced 1708307 12 19 85 Y1253F inhibited full activation. ; Y771F mutation completely blocked activation, while Y774F enhanced activation +POLH POLH DNA repair, damage; EC 2.7.7.7; Transferase Q9Y253 5429 6p21.1 human K486-sm 1877365915 SLESFFQkAAERQKV intracellular localization; enzymatic activity, inhibited 32350109 1 1 0 +Esr1 ER-alpha DNA-binding; Nuclear receptor; Transcription factor P19785 13982 10 A1|10 2.03 cM mouse S216-p 12127402 CKAFFKRsIQGHNDY zf-C4 molecular association, regulation cell motility, induced; apoptosis, inhibited; transcription, induced; transcription, inhibited CaR(INDUCES) DNA(INDUCES) 24386386; 26585153; 32193417; 32727504 8 1 0 +CSNK1E CK1E EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, CK1; Protein kinase, Ser/Thr (non-receptor) P49674 1454 22q13.1 human S389-p 482888 RGAPANVsSSDLTGR protein degradation transcription, altered 17525164 1 18 13 phaosphorylation induces degredation of mPer2 and expression of circadian clock genes. +MYH9 MYH9 Actin-binding; Motility/polarity/chemotaxis; Motor P35579 4627 22q12.3 human S1943-p 456730 RKGAGDGsDEEVDGK molecular association, regulation; intracellular localization cell cycle regulation; carcinogenesis, inhibited; cell adhesion, induced; cell motility, altered; cytoskeletal reorganization S100A4(DISRUPTS); Cas-L(INDUCES) 17567956; 18971378; 19826041; 21316371; 22123909; 28053086; 30087119; 30267961 14 118 916 +STK38 NDR1 EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, AGC; Protein kinase, Ser/Thr (non-receptor) Q15208 11329 6p21.31 human T444-p 460659 DWVFINYtYKRFEGL Pkinase_C molecular association, regulation; phosphorylation; enzymatic activity, induced cell cycle regulation; cytoskeletal reorganization MOB1A(INDUCES); CCND1(INDUCES); MOB1B(NOT_REPORTED) 12493777; 19836237; 22445341; 23897809; 26057687 7 2 1 reduction in dendritic branching and length ; lower level of T444 phosphorylation in mitosis; NDR1 Y31A and Y74A mutants showed highly decreased T444 phosphorylation and centrosome amplification. +Slc1a2 GLT1 Membrane protein, integral; Membrane protein, multi-pass; Transporter; Transporter, SLC family P31596 29482 3q32 rat K517-ub 3932336 HEDIEMTkTQSVYDD receptor internalization, induced; protein degradation 18805448 1 1 4 +Plk1 PLK1 EC 2.7.11.21; KINASE; Kinase, protein; Protein kinase, Other; Protein kinase, Ser/Thr (non-receptor) Q07832 18817 7 F2|7 65.52 cM mouse Y166-p 54066600 QIVLGCQyLHRNQVI Pkinase enzymatic activity, induced cell cycle regulation 26755576 1 0 0 +MYH10 MYH10 Motility/polarity/chemotaxis; Motor P35580 4628 17p13.1 human S1935-p 4730818 LRRGGPIsFSSSRSG molecular association, regulation; intracellular localization cytoskeletal reorganization MYH10(INDUCES); ACTA1(INDUCES) 25869664; 30655296 2 18 0 +GLI3 GLI3 C2H2-type zinc finger protein; Transcription factor P10071 2737 7p14.1 human K800-ub 6097710 LNPILPPkAPAVSPL protein processing 16705181 1 0 0 +PALLD palladin Cytoskeletal; Motility/polarity/chemotaxis Q8WX93 23022 4q32.3 human S808-p 22826102 PPPPPVFsPTAAFPV molecular association, regulation cell motility, inhibited Abl(DISRUPTS) 22216253 1 0 0 +Fos Fos DNA-binding; Motility/polarity/chemotaxis; Oncoprotein; Transcription factor P01101 14281 12 D2|12 39.7 cM mouse S32-p 470080 DSLSYYHsPADSFSS intracellular localization transcription, induced 34496234 4 0 0 +Nfatc1 NFAT2 iso4 DNA-binding; Transcription factor Q6P7T9 18018 18 E3|18 53.66 cM mouse S259-p 40512526 SWLGARGsRPTSPCN intracellular localization transcription, inhibited 32997697 5 3 0 +MRTFA MKL1 Oncoprotein; Transcription, coactivator/corepressor Q969V6 57591 22q13.1-q13.2 human K624-sm 2407400 GPPSVVVkQEALQPE transcription, inhibited 16098147 1 0 0 +PAK6 PAK6 EC 2.7.11.1; KINASE; Kinase, protein; Nuclear receptor co-regulator; Protein kinase, STE; Protein kinase, Ser/Thr (non-receptor) Q9NQU5 56924 15q15.1 human T326-p 29666306 SPLTTSDtSSPQKSL molecular association, regulation; enzymatic activity, induced carcinogenesis, induced; cell motility, induced AR(INDUCES) 24130878 1 2 0 promotion of cell motility and invasion +Drd1 DRD1 GPCR, family 1; Membrane protein, integral; Membrane protein, multi-pass; Receptor, GPCR P18901 24316 17p14 rat S421-p 30310300 EKLSPALsVILDYDT intracellular localization; enzymatic activity, induced signaling pathway regulation 24362306 2 0 0 induced ERK1/2 activation; inhibition of phosphorylation leads to induce locomotor hyperactivity +KCNIP3 calsenilin Calcium-binding; Transcription factor Q9Y2W7 30818 2q11.1 human K26-sm 25336512 LGHTPLSkKEGIKWQ intracellular localization transcription, inhibited 21070824 1 0 0 +MKNK1 Mnk1 iso2 EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, CAMK; Protein kinase, Ser/Thr (non-receptor); Translation Q9BUB5-2 8569 1p33 human S353-p 56790200 QVLQRNSsTMDLTLF activity, inhibited 28545025 2 1 0 +PTPRJ PTPRJ EC 3.1.3.48; Membrane protein, integral; Motility/polarity/chemotaxis; PHOSPHATASE; Receptor protein phosphatase, tyrosine Q12913 5795 11p11.2 human Y1320-p 15228667 NTTAMTIyENLAPVT molecular association, regulation; enzymatic activity, induced cell motility, induced Src(INDUCES) 22898603 2 1 1 +COPS5 COPS5 Adaptor/scaffold; DEUBIQUITINASE; EC 3.4.-.-; Nuclear receptor co-regulator; Protease; Transcription, coactivator/corepressor; Translation Q92905 10987 8q13.1 human S320-p 33365506 EAIHGLMsQVIKDKL CSN5_C protein stabilization 24710276 1 1 0 deubiquitinates and stabilizes PEA-15 +Cox4i1 COX4I1 EC 1.9.3.1; Energy Metabolism - oxidative phosphorylation; Membrane protein, integral; Mitochondrial; Oxidoreductase P19783 12857 8 E1|8 69.99 cM mouse S58-p 479944 HVTMLSAsQKALKEK COX4 molecular association, regulation; enzymatic activity, induced cell growth, induced 21641552 2 9 2 phosphorylation of this site prevents ATP binding +GRIA1 GluR1 Channel, calcium; Channel, ligand-gated; Membrane protein, integral; Membrane protein, multi-pass P42261 2890 5q33.2 human S836-p 467226 CYKSRSEsKRMKGFC molecular association, regulation; intracellular localization EPB41L1(INDUCES) 19503082 6 0 0 enhances receptor insertion into plasma membrane +Etv1 ETV1 DNA-binding; Oncoprotein; Transcription factor P41164 14009 12 A3|12 17.99 cM mouse T139-p 3059605 MRPSNPPtPSSTPVS ETS_PEA3_N activity, induced transcription, induced; signaling pathway regulation 22586091 2 0 0 +CDK9 CDK9 Cell cycle regulation; EC 2.7.11.22; EC 2.7.11.23; KINASE; Kinase, protein; Nuclear receptor co-regulator; Protein kinase, CMGC; Protein kinase, Ser/Thr (non-receptor) P50750 1025 9q34.11 human K48-ac 486372 TGQKVALkKVLMENE Pkinase enzymatic activity, inhibited cell cycle regulation; DNA repair, inhibited 23898190 2 1 0 +HTRA2 HTRA2 EC 3.4.21.108; Membrane protein, integral; Mitochondrial; Protease O43464 27429 2p13.1 human S142-p 487466 VPSPPPAsPRSQYNF Peptidase_M50 enzymatic activity, induced carcinogenesis, inhibited; cytoskeletal reorganization 17906618; 24662565 4 0 1 phosphorylation of this site activates beta actin cleavage and decreases F actin presence in the cytosol +Hmga1 HMGA1 DNA-binding Q8K585 117062 20p12 rat T53-p 451515 KEPSEVPtPKRPRGR molecular association, regulation DNA(DISRUPTS) 10617144 4 55 35 +Eps8 EPS8 Adaptor/scaffold Q08509 13860 6 G1|6 66.78 cM mouse Y534-p 63063500 VKTQPKKyAKSKYDF phosphorylation carcinogenesis, induced; cell motility, induced; cell growth, induced; cell adhesion, induced 28214294 1 1 0 enhanced phosphorylation of ERK and FAK, increased cell adhesion and anchorage-dependent colony formation +RUNX1 AML1 DNA-binding; Oncoprotein; Transcription factor Q01196 861 21q22.12 human K182-ub 15384404 EPRRHRQkLDDQTKP protein degradation; intracellular localization carcinogenesis, inhibited; cell growth, inhibited; transcription, inhibited 28536267 1 3 1 +NR3C2 MCR DNA-binding; Nuclear receptor P08235 4306 4q31.23 human K494-sm 3144809 SGFPVGIkQEPDDGS transcription, induced; transcription, inhibited 14500761; 17105732 3 1 0 Ubc9 can be a transcriptional mineralocorticoid receptor coactivator. +PPP1R1A PPP1R1A Inhibitor; Protein phosphatase, regulatory subunit P01099 rabbit T35-p 447759 QIRRRRPtPATLVLT DARPP-32 molecular association, regulation; enzymatic activity, inhibited PPP1CA(INDUCES) 29311589 14 4 0 PKA-thiophosphorylated form of inhibitor-1 displays a different affnity to native and recombinant enzyme +SLC1A2 GLT1 Membrane protein, integral; Membrane protein, multi-pass; Transporter; Transporter, SLC family P43004 6506 11p13 human K551-ub 4667700 SVIVDECkVTLAANG molecular association, regulation GLT1(INDUCES) 35938532 2 0 0 formation of oligomers, epileptic seizures inhibited by APAP treatment +FMR1 FMR1 Nucleolus; RNA-binding; Translation Q06787 2332 Xq27.3 human S511-p 14323700 SDHRDELsDWSLAPT FXMRP1_C_core intracellular localization 20417602 4 1 0 +CASP6 CASP6 Apoptosis; EC 3.4.22.59; Protease P55212 839 4q25 human S257-p 452136 TLVNRKVsQRRVDFC Peptidase_C14 molecular association, regulation; enzymatic activity, inhibited; protein conformation apoptosis, inhibited Other(DISRUPTS) 22433863; 22483120 3 0 0 prevents binding to VEID-CHO and z-VAD-FMK; S257E mutation inhibits CASP6 self-activation in vitro +Rela NFkB-p65 DNA-binding; Nuclear receptor co-regulator; Transcription factor Q7TQN4 309165 1q43 rat S528-p 447799 SGLPNGLsGDEDFSS autophagy, induced 37237886 27 3 1 +DGCR8 DGCR8 Nucleolus; RNA processing; RNA-binding Q8WYQ5 54487 22q11.21 human S373-p 4777519 QSSDLTPsGDVSPVK protein stabilization 24239349 1 23 0 +KIF4A KIF4A Microtubule-binding; Motor O95239 24137 Xq13.1 human S801-p 459849 KLRRRTFsLTEVRGQ intracellular localization cell cycle regulation 28992084; 31881080 3 48 98 +POLL POLL DNA repair, damage; EC 2.7.7.7; Lyase; Transferase Q9UGP5 27343 10q24.32 human T553-p 5312301 GPGRVLPtPTEKDVF DNA_pol_B_thumb protein stabilization; ubiquitination 18688254 1 0 0 prevents POLL ubiquitination +DOCK1 DOCK1 Adaptor/scaffold; Cytoskeletal; GEF; GEF, Rac/Rho; Motility/polarity/chemotaxis Q14185 1793 10q26.2 human S1250-p 28698600 HAKLLKWsEDVCVAH DHR-2_Lobe_A molecular association, regulation carcinogenesis, induced; cell motility, induced; cell growth, induced; signaling pathway regulation RAC1(INDUCES) 23728337; 25468898 2 0 0 plays a role in EGFR-based glioblastoma carcinogenesis; PDGFRA initiated signaling-Rac1-Akt, ERK1/2 +CAV1 caveolin-1 Adaptor/scaffold; Motility/polarity/chemotaxis; Nuclear receptor co-regulator Q03135 857 7q31.2 human K47-ub 21171000 QVYDAHTkEIDLVNR Caveolin molecular association, regulation; intracellular localization UBXN6(INDUCES); VCP(INDUCES) 23335559 1 7 0 CAV1 ubiquitylation and binding to the VCP-UBXD1 complex and sorting into lysosomes +Sirt1 SIRT1 Apoptosis; DEACETYLASE; Deacetylase; EC 3.5.1.-; Nuclear receptor co-regulator NP_001401888 309757 20p11 rat K725-sm 1968605 VNEAIAMkQELTDVN sumoylation; molecular association, regulation autophagy, inhibited SUMO1(DISRUPTS); FAT10(DISRUPTS) 33307094 2 1 0 FAT10 regulates autophagy as a cardiac protector; FAT10 inhibits autophagy by inhibiting SIRT1 SUMOYylation +ADAR ADAR EC 3.5.4.37; Hydrolase; Nucleolus; RNA processing; RNA-binding P55265 103 1q21.3 human K576-ub 59149207 LLEEAKAkDSGKSEE protein degradation 27729454 1 0 0 regulation of IFN-signaling induced anti-viral activity +XRCC1 XRCC1 DNA repair, damage P18887 7515 19q13.31 human S409-p 3181462 LMAGPGSsSEEDEAS molecular association, regulation PARP1(DISRUPTS) 25477519 2 5 0 +MYBL2 B-Myb DNA-binding; Motility/polarity/chemotaxis; Transcription factor P10244 4605 20q13.12 human Y15-p 25284053 EDLDELHyQDTDSDV protein stabilization; molecular association, regulation VHL(DISRUPTS) 27090638 1 0 1 +Ctnnd1 CTNND1 Actin-binding; Adaptor/scaffold; Cell adhesion; G protein regulator, misc.; Motility/polarity/chemotaxis P30999 12388 2 D|2 49.45 cM mouse Y217-p 449647 PDGYGRHyEDGYPGG molecular association, regulation CDH1(INDUCES); RHOA(INDUCES) 17194753 2 13 102 +RAD17 RAD17 Cell cycle regulation O75943 5884 5q13.2 human S367-p 23136922 LKSDAVLsKSKRRKK molecular association, regulation RAD1(INDUCES) 29902452 1 0 1 +Npr1 ANPA EC 4.6.1.2; Guanylyl cyclase; KINASE; Kinase, protein; Lyase; Membrane protein, integral; Nucleotide Metabolism - purine; Protein kinase, RGC; Protein kinase, dual-specificity (receptor); Receptor, misc. P18910 24603 2q34 rat S515-p 14364503 WEDLQPSsLERHLRS receptor desensitization, altered; enzymatic activity, inhibited; protein conformation 20456499; 20977274 2 2 0 +Pick1 PICK1 Adaptor/scaffold; Cell development/differentiation; Ligand, receptor tyrosine kinase Q9EP80 84591 7q34 rat T82-p 14146800 GRSIKGKtKVEVAKM PDZ molecular association, regulation GluR2(DISRUPTS) 20403402 1 0 0 disrupts GluR2 clustering +DGKA DGKA EC 2.7.1.107; Kinase, lipid; Lipid Metabolism - glycerolipid; Lipid Metabolism - glycerophospholipid; Motility/polarity/chemotaxis P23743 1606 12q13.2 human Y335-p 486452 ILPPSSIyPSVLASG intracellular localization; enzymatic activity, induced carcinogenesis, induced; cell growth, induced; cell motility, altered 15773894; 17700527; 18424699; 35962191 5 0 0 +NELFE RDBP Mitochondrial; Transcription, coactivator/corepressor P18615 7936 6p21.33 human S251-p 468611 GPFRRSDsFPERRAP molecular association, regulation transcription, induced 14-3-3 epsilon(INDUCES) 29523821 1 26 2 dissociation of the NELF complex from chromatin, which is accompanied by RNA polymerase II elongation +DDX3X DDX3 Cell cycle regulation; EC 3.6.4.13; Helicase; RNA-binding; Spliceosome; Translation initiation O00571 1654 Xp11.4 human K118-ac 461737 GDRSGFGkFERGGNS transcription, induced 34158847 1 2 14 malonylation on lysine 66, 130 and 62 inhibits transcription +VHL VHL Tumor suppressor; UBIQUITIN LIGASE; Ubiquitin ligase P40337 7428 3p25.3 human S33-p 15573201 EEDGGEEsGAEESGP protein degradation transcription, altered 20637892; 26973240 2 0 0 VHL clevaage and subsequent degradation; regulates p53 activity and degradation of HIF1A +ZRANB1 ZRANB1 DEUBIQUITINASE; EC 3.4.19.12; Ligase; Protease; Ubiquitin conjugating system; Ubiquitin-specific protease Q9UGI0 54764 10q26.13 human S209-p 23077543 RWRGSCSsGNSQRRS activity, induced signaling pathway regulation 30686098 1 1 2 +Dnajc5 DNAJC5 Vesicle P60905 79130 3q43 rat S10-p 448129 DQRQRSLsTSGESLY neural plasticity STX1A(DISRUPTS) 11604405; 35543445 7 80 344 +Mapk8ip1 JIP1 Adaptor/scaffold Q9WVI9 19099 2|2 E1 mouse T201-p 449954 PLKTGEQtPPHEHIC ubiquitination; phosphorylation cell growth, induced 35581583 2 1 0 induces Itch phosphorylation and Notch1 ubiquitination +Irs1 IRS1 Adaptor/scaffold; Motility/polarity/chemotaxis P35570 25467 9q34 rat S302-p 450190 TRRSRTEsITATSPA phosphorylation 36207218 56 12 1 inhibits phosphorylation of PI3K, AKT, and eNOS +App APP iso2 Apoptosis; Cell surface; Membrane protein, integral; Receptor, misc.; Transcription factor P12023-2 11820 16 C3.3|16 46.92 cM mouse S655-p 448200 LKKKQYTsIHHGVVE APP_amyloid molecular association, regulation; protein processing BACE(INDUCES) 31287605 6 1 0 amyloidogenic processing +CDKN1A p21Cip1 Cell cycle regulation; Inhibitor P38936 1026 6p21.2 human K75-ub 9897000 VRGLGLPkLYLPTGP protein degradation; ubiquitination 13678583; 17429006 4 6 4 under chelated Fe2+ conditions p21Cip1 is degraded by ubiquitin independent proteasomal degradation.; UV-induced +Fcer1g FCER1G Membrane protein, integral; Receptor, misc. P20491 14127 1 H3|1 79.23 cM mouse Y65-p 451737 REKADAVyTGLNTRS ITAM molecular association, regulation endocytosis, induced Cbl-b(DISRUPTS) 27428899 4 15 593 +BAG3 BAG3 Apoptosis; Chaperone O95817 9531 10q26.11 human S377-p 452222 PVPCPPPsPGPSAVP protein degradation; molecular association, regulation; ubiquitination cell cycle regulation; carcinogenesis, inhibited; cell growth, inhibited; apoptosis, induced; cell motility, inhibited FBXO22(INDUCES) 34215846 3 44 16 +FH fumarase Carbohydrate Metabolism - citrate (TCA) cycle; EC 4.2.1.2; Lyase; Mitochondrial; Tumor suppressor P07954 2271 1q43 human T90-p 3823351 GVTERMPtPVIKAFG Lyase_1 molecular association, regulation carcinogenesis, inhibited; cell growth, inhibited; transcription, induced; signaling pathway regulation p53(INDUCES); RBPJ(INDUCES) 30683654 1 9 3 Notch signaling; induces transcription of p21 +Nr1d1 NR1D1 Nuclear receptor; Transcription factor Q3UV55 217166 11|11 D mouse T275-p 55578702 SQFPQQLtPPRSPSP protein degradation 27238018 1 0 0 modulate amplitude of circadian clock +EGR1 EGR1 C2H2-type zinc finger protein; DNA-binding; Transcription factor P18146 1958 5q31.2 human S301-p 11423702 AFATQSGsQDLKALN protein stabilization transcription, induced; transcription, altered DNA(DISRUPTS) 34562454; 8662759 2 1 0 +DYNLL2 DYNLL2 Microtubule-binding; Motility/polarity/chemotaxis; Motor Q96FJ2 140735 17q22 human S88-p 18610003 VAILLFKsG______ Dynein_light molecular association, regulation BMF(DISRUPTS); MYO5A(DISRUPTS) 20889982 1 0 0 +Ern1 IRE1 Apoptosis; Chaperone; EC 2.7.11.1; Endoplasmic reticulum; KINASE; Kinase, protein; Membrane protein, integral; Protein kinase, Other; Protein kinase, Ser/Thr (non-receptor); Ribonuclease Q9EQY0 78943 11|11 E1 mouse S729-p 53407300 RHSFSRRsGVPGTEG Pkinase RNA splicing, induced 29511123 2 2 0 expression of spliced XBP1; RE1-dependent decay (RIDD) of other mRNAs +Btk Btk EC 2.7.10.2; KINASE; Kinase, protein; Protein kinase, TK; Protein kinase, tyrosine (non-receptor) P35991 12229 X E3|X 56.18 cM mouse Y223-p 447485 LKKVVALyDYMPMNA SH3_1 molecular association, regulation; palmitoylation; enzymatic activity, induced carcinogenesis, induced; apoptosis, inhibited; signaling pathway regulation; cell growth, altered GTF2I(INDUCES) 34582250; 36160379; 9012831; 9391111 41 14 250 PI 3-kinase is required for BTK activation and transformation. +FSCN1 fascin Actin-binding; Cytoskeletal; Motility/polarity/chemotaxis Q16658 6624 7p22.1 human K353-ub 60122801 TLRASNGkFVTSKKN Fascin cytoskeletal reorganization 27879315 1 1 0 fascin bundling activity +TNKS TNKS EC 2.4.2.30; Transferase O95271 8658 8p23.1 human T930-p 21326700 LAHGADPtMKNQEGQ Ank_5 protein stabilization; intracellular localization; enzymatic activity, induced cell cycle regulation; cell growth, induced 21818122 1 0 1 +ATG16L1 ATG16L1 iso2 Adaptor/scaffold; Autophagy; Membrane protein, peripheral Q676U5-2 55054 2q37.1 human S268-p 3202215 SRAATRRsVSSFPVP protein degradation autophagy, inhibited 31580256 3 32 0 +OPRD1 DOR-1 GPCR, family 1; Membrane protein, integral; Membrane protein, multi-pass; Receptor, GPCR P41143 4985 1p35.3 human T361-p 448551 RERVTACtPSDGPGG receptor inactivation, induced; receptor internalization, induced 32444688 4 1 0 +ADAR ADAR EC 3.5.4.37; Hydrolase; Nucleolus; RNA processing; RNA-binding P55265 103 1q21.3 human K418-sm 3726902 NGQEPVIkLENRQEA enzymatic activity, inhibited 16120648 1 5 0 +HABP4 HABP4 Transcription regulation Q5JVS0 22927 9q22.32 human K213-sm 1873147500 DAFDQRGkREFERYG HABP4_PAI-RBP1 molecular association, regulation 28695742 1 0 0 Presence of SUMO-1 strongly influences the interaction of HABP4 (Ki-1/57) with other cellular proteins.; Fewer PML-nuclear bodies when compared to non-SUMOylated triple mutants, but not when treated with As2O2 +EGFR EGFR EC 2.7.10.1; KINASE; Kinase, protein; Membrane protein, integral; Oncoprotein; Protein kinase, TK; Protein kinase, tyrosine (receptor) P00533 1956 7p11.2 human K714-ub 1065307 LKETEFKkIKVLGSG PK_Tyr_Ser-Thr receptor recycling, inhibited; protein degradation 16543144; 17940017 2 2 0 +YAP1 YAP1 Oncoprotein; Transcription, coactivator/corepressor P46937 10413 11q22.1 human T241-gl 93432001 DGWEQAMtQDGEIYY WW protein stabilization; molecular association, regulation; phosphorylation carcinogenesis, induced; cell growth, induced LATS1(DISRUPTS) 28474680 1 0 0 inhibits phosphorylation at S127 +Ctnnd1 CTNND1 iso3 Actin-binding; Adaptor/scaffold; Cell adhesion; G protein regulator, misc.; Motility/polarity/chemotaxis P30999-3 12388 2 D|2 49.45 cM mouse Y257-p 450397 APSRQDVyGPQPQVR cell cycle regulation; cell motility, altered 18515860 2 27 754 +XRCC4 XRCC4 DNA repair, damage Q13426 7518 5q14.2 human T233-p 2286405 DPVYDEStDEESENQ XRCC4 molecular association, regulation APLF(INDUCES); Pnk1(INDUCES) 18077224; 20852255 2 9 0 +Zeb1 TCF8 C2H2-type zinc finger protein; DNA-binding; Motility/polarity/chemotaxis; Transcription, coactivator/corepressor Q62947 25705 17q12.1 rat T867-p 469215 DQNDSDCtPPKKKTR intracellular localization transcription, induced 26868487 1 0 5 disrrupts nuclear localization +Hif3a HIF3A iso2 Transcription factor; Tumor suppressor Q0VBL6-2 53417 7|7 A2 mouse S184-p 291887100 HFSLRMKsTLTSRGR apoptosis, induced 29054108 1 1 0 mitochondrial clustering +HOXB13 HOXB13 DNA-binding; Transcription factor Q92826 10481 17q21.32 human S31-p 1883583910 GRNLVAHsPLTSHPA protein degradation; molecular association, regulation; ubiquitination; intracellular localization carcinogenesis, induced; cell growth, induced; transcription, altered SKP2(INDUCES) 37409967 1 0 0 induces nuclear translocation of NFKB +AKAP8 AKAP8 Adaptor/scaffold; Cell cycle regulation; Mitochondrial; RNA-binding O43823 10270 19p13.12 human Y154-p 476956 RPSYSYDyEFDLGSD molecular association, regulation 25770215 1 0 1 Phenylalanine mutants inhibited dissociation from nuclear structures; structural chromatin changes +SFN 14-3-3 sigma Adaptor/scaffold P31947 2810 1p36.11 human Y130-p 38485859 MKGDYYRyLAEVATG 14-3-3 molecular association, regulation SKP1A(INDUCES) 30728155 1 0 0 +EIF4A3 DDX48 EC 3.6.4.13; Helicase; RNA splicing; RNA-binding; Spliceosome P38919 9775 17q25.3 human T163-p 3190132 GQHVVAGtPGRVFDM DEAD molecular association, regulation; intracellular localization cell cycle regulation; RNA splicing, inhibited; RNA stability, induced; cytoskeletal reorganization; translation, induced NCM(INDUCES) RNA(DISRUPTS) 30784594 2 27 1 inhibits mRNA decay (NMD); T163 phosphorylation triggers/induces exon junction complex( EJC) remodeling +RBL2 Rb-like 2 Transcription, coactivator/corepressor; Tumor suppressor Q08999 5934 16q12.2 human S672-p 448254 TLYDRYSsPPASTTR protein degradation; molecular association, regulation cell cycle regulation; transcription, induced SKP2(INDUCES); E2F4(DISRUPTS); LIN9(DISRUPTS); DKFZp686L1814(DISRUPTS) 11157749; 12006580; 12435635; 28289097; 35235778 6 4 7 +Rigi RIGI EC 3.6.4.13; Hydrolase Q6Q899 230073 4|4 A5 mouse K18-m1 1883825700 AFRDYIKkILDPTYI CARD_2 molecular association, regulation carcinogenesis, induced; signaling pathway regulation AMPKA1(INDUCES); STAT3(DISRUPTS) 36333807 1 1 0 RIGI demethylation inhibited IL-6-STAT3 signaling; demethylation of RIG-I to enhances RIGI-STAT3 association; JMJD4 and RIGI co-operatively inhibit DEN-induced hepatocarcinogenesis and steatosis; methylated RIG-I associates with AMPKA1 to inhibit HMGCR phosphorylation and promote cholesterol synthesis and NAFLD progression +ETAA1 ETAA16 Cell surface Q9NY74 54465 2p14 human S95-p 1869465805 SLSSSFSsPNDPDGQ ETAA1 cell cycle regulation; signaling pathway regulation 31615875 1 0 0 critical for chromosome stability +TP53 p53 Activator; DNA-binding; Motility/polarity/chemotaxis; Nuclear receptor co-regulator; Transcription factor; Tumor suppressor P04637 7157 17p13.1 human S367-p 1881548604 GGSRAHSsHLKSKKG protein degradation; molecular association, regulation; ubiquitination; intracellular localization cell cycle regulation; cell growth, induced; apoptosis, inhibited; transcription, inhibited DNA(DISRUPTS) 37041410 1 1 0 +Traf6 TRAF6 EC 6.3.2.-; Ligase; UBIQUITIN LIGASE; Ubiquitin conjugating system; Ubiquitin ligase P70196 22034 2|2 E2 mouse S13-p 25757009 CENSCGSsQSSSDCC intracellular localization 27818144 1 0 1 nuclear localization +CIITA CIITA DNA-binding; EC 2.7.11.1; KINASE; Protein kinase, Ser/Thr (non-receptor); Transcription, coactivator/corepressor P33076 4261 16p13.13 human S293-p 2902203 STSPFAPsATDLPSM intracellular localization transcription, altered 15210796 1 0 0 +RICTOR RICTOR Adaptor/scaffold; Cell cycle regulation; Ubiquitin conjugating system Q6R327 253260 5p13.1 human K1119-ac 41692102 SSDPKGGkLSSESKT RICTOR_phospho signaling pathway regulation 26170313 1 0 0 induces mTORC2 signaling +Septin5 SEPT5 Cell cycle regulation; Cytoskeletal; Hydrolase; Vesicle Q9JJM9 116728 11q23 rat S161-p 2753800 HCCLYFIsPFGHGLR Septin molecular association, regulation exocytosis, altered STX1A(DISRUPTS) 18385322 1 0 0 +COL17A1 COL17A1 Extracellular matrix; Membrane protein, integral; Motility/polarity/chemotaxis Q9UMD9 1308 10q25.1 human S544-p 484007 KIGLHSDsQEELWMF cell adhesion, altered 17545155 1 0 0 regulates COL17A1 shedding of ectodomain +SET SET iso2 Apoptosis; DNA replication; DNA-binding; Inhibitor; Nuclear receptor co-regulator; Oncoprotein; Protein phosphatase, regulatory subunit Q01105-2 6418 9q34.11 human S171-p 27425001 KDLTKRSsQTQNKAS NAP molecular association, regulation; phosphorylation; enzymatic activity, induced signaling pathway regulation SET iso2(DISRUPTS) 23251465; 30917007 2 0 0 +FLCN FLCN Tumor suppressor Q8NFG4 201163 17p11.2 human S571-p 31085315 HLMSTVRsPTASESR intracellular localization; phosphorylation cell cycle regulation; carcinogenesis, induced; signaling pathway regulation 31395606 1 5 0 induces localization of mTORC1, increases phosphorylation of mTORC1 targets, regulates mTORC1 pathway +TICAM1 TICAM1 Adaptor/scaffold; Apoptosis Q8IUC6 148022 19p13.3 human S210-p 31858079 LASNLEIsQSPTMPF molecular association, regulation; phosphorylation IRF3(INDUCES) 25636800 1 1 0 induces IFN production +SQLE SQLE EC 1.14.13.132; Endoplasmic reticulum; Lipid Metabolism - steroid biosynthesis; Membrane protein, integral; Membrane protein, multi-pass; Oxidoreductase Q14534 6713 8q24.13 human S83-ub 1879784804 IGFFWAKsPPESENK protein degradation 30940729 1 1 0 cholesterol-accelerated degradation +GRK2 GRK2 EC 2.7.11.15; KINASE; Kinase, protein; Protein kinase, AGC; Protein kinase, Ser/Thr (non-receptor) P25098 156 11q13.2 human Y86-p 447727 ARPLVEFyEEIKKYE RGS protein degradation; molecular association, regulation G-alpha(q)(INDUCES) 11566877; 16725308 5 0 0 +MATR3 matrin 3 RNA processing; RNA-binding P43243 9782 5q31.2 human T150-p 1218501 LQLKRRRtEEGPTLS intracellular localization 20962082 2 20 50 +PLIN3 perilipin 3 Vesicle O60664 10226 19p13.3 human Y251-p 1873650102 ERLRQHAyEHSLGKL Perilipin protein degradation; molecular association, regulation autophagy, induced; cell growth, induced; apoptosis, inhibited HSC70(INDUCES) 34077757 1 1 0 +CDKN1B p27Kip1 Cell cycle regulation; Inhibitor; Oncoprotein; Protein kinase, regulatory subunit P46527 1027 12p13.1 human Y88-p 456818 KGSLPEFyYRPPRPP protein degradation; molecular association, regulation; ubiquitination; intracellular localization; protein conformation; activity, inhibited; phosphorylation cell cycle regulation; carcinogenesis, induced; cell growth, induced SKP2(INDUCES); CDK2(INDUCES); CDK4(DISRUPTS); CDK2(DISRUPTS); CDK4(INDUCES) 16195327; 17254966; 17908796; 21423214; 21423803; 22276948; 33147476; 35247157; 37443738 14 0 0 +Notch3 NOTCH3 Membrane protein, integral Q61982 18131 17 B1|17 17.37 cM mouse S1673-p 11179168 ARRKREHsTLWFPEG protein stabilization; molecular association, regulation; intracellular localization carcinogenesis, induced; transcription, inhibited CSL(DISRUPTS) 33775697 1 1 1 +APOBEC3G APOBEC3G EC 3.5.4.-; Hydrolase; RNA processing; RNA-binding Q9HC16 60489 22q13.1 human T218-p 21656100 WVRGRHEtYLCYEVE NAD2 enzymatic activity, inhibited 21659520 2 0 0 +Glp1r GLP1R GPCR, family 2; Membrane protein, integral; Membrane protein, multi-pass; Receptor, GPCR P32301 25051 20p12 rat S452-p 451370 SGATVGSsVYAATCQ receptor desensitization, altered 8702711 1 0 0 +CSNK1A1 CK1A EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, CK1; Protein kinase, Ser/Thr (non-receptor) P48729 1452 5q32 human K179-ub 54227300 HIPYREDkNLTGTAR Pkinase protein degradation 26909574 1 1 0 +RUNX3 AML2 DNA-binding; Transcription factor Q13761 864 1p36.11 human S356-p 7705800 SSSGGDRsPTRMLAS RunxI protein degradation; ubiquitination transcription, altered 19351720 1 0 0 degradation by cyclin D1 +RAP1GAP2 RAP1GAP2 GAP; GAP, Ras Q684P5 23108 17p13.3 human S9-p 1319201 FGRKRSVsFGGFGWI molecular association, regulation 14-3-3 beta(INDUCES); 14-3-3 zeta(INDUCES) 18039662 1 10 10 14-3-3 binding attenuates Rap1GAP2 mediated inhibition of cell adhesion +HJURP HJURP Histone-binding; Nucleolus Q8NCD3 55355 2q37.1 human S210-p 27449204 GDPAKPAsSPREWDP molecular association, regulation cell cycle regulation 28017591 1 2 0 prevents premature CENP-A assembly +Map3k7 TAK1 iso3 EC 2.7.11.25; KINASE; Kinase, protein; Protein kinase, Ser/Thr (non-receptor); Protein kinase, TKL Q923A8 26409 4|4 A5 mouse S439-p 455196 NGQPRRRsIQDLTVT activity, induced; molecular association, regulation apoptosis, induced; signaling pathway regulation TAB2(INDUCES); TRAF6(INDUCES) 30626936 9 83 63 Phosphorylation of JNK, p38 and IkB (subsequent degradation) +FFAR4 GPR120 iso1 GPCR, family 1; Lipid-binding; Membrane protein, integral; Membrane protein, multi-pass; Receptor, GPCR Q5NUL3-1 338557 10q23.33 human S366-p 31014808 GAILTDTsVKRNDLS receptor internalization, induced; molecular association, regulation ARR3(INDUCES); ARRB1(INDUCES) 24412271; 24817122 5 1 0 +Gja1 GJA1 Channel, misc.; Membrane protein, integral; Membrane protein, multi-pass; Motility/polarity/chemotaxis P23242 14609 10 B4|10 28.64 cM mouse S279-p 448853 SSPTAPLsPMSPPGY activity, induced; receptor internalization, induced; protein degradation; ubiquitination; intracellular localization; phosphorylation cell growth, induced 22729691; 25952543; 29959233; 30872361; 30981509 42 6 1 +Stxbp5l STXBP5L Q5DQR4 207227 16 26.32 cM|16 B3 mouse K309-sm 31957313 ESCKPILkVEYKTCR LLGL neural plasticity 24614299 1 0 0 +Tab2 TAB2 Adaptor/scaffold Q99K90 68652 10|10 A1 mouse K562-sm 1877015600 KKKLDKLkSEVNEME molecular association, regulation transcription, inhibited; signaling pathway regulation 33184450 1 0 0 inhibition of TRAF6/TAB2/TAK1 complex and downstream MAPK and NF-?B pathway +HIVEP3 HIVEP3 C2H2-type zinc finger protein; Transcription, coactivator/corepressor Q5T1R4 59269 1p34.2 human T869-p 1874499602 EEPDRPDtEPEPPPK molecular association, regulation 14-3-3 beta(INDUCES); 14-3-3 sigma(INDUCES); 14-3-3 theta(INDUCES); 14-3-3 zeta(INDUCES); 14-3-3 epsilon(INDUCES); 14-3-3 gamma(INDUCES); 14-3-3 eta(INDUCES) 34341191 1 0 0 +STAT5A STAT5A DNA-binding; Motility/polarity/chemotaxis; Oncoprotein; Transcription factor P42229 6776 17q21.2 human T92-gl 5262510 IKLGHYAtQLQKTYD STAT_int molecular association, regulation transcription, induced CBP(INDUCES) 14597631 1 1 0 +EPOR EPOR Membrane protein, integral; Receptor, cytokine P19235 2057 19p13.2 human Y489-p 457448 DGPYSNPyENSLIPA apoptosis, inhibited 14662339 4 0 0 +NTRK1 TrkA EC 2.7.10.1; KINASE; Kinase, protein; Membrane protein, integral; Oncoprotein; Protein kinase, TK; Protein kinase, tyrosine (receptor) P04629 4914 1q23.1 human Y791-p 447765 LAQAPPVyLDVLG__ molecular association, regulation; enzymatic activity, induced apoptosis, induced; signaling pathway regulation; cell growth, altered PLCG1(INDUCES) 10617652; 35471943; 8155326; 8384556 9 0 2 regulates NGF-TrkA? and PLC-mediated pathways; regulate NGF induced neurite outgrowth and ERK activity +PRKCD PKCD EC 2.7.11.13; KINASE; Kinase, protein; Nuclear receptor co-regulator; Protein kinase, AGC; Protein kinase, Ser/Thr (non-receptor); Protein kinase, tyrosine (non-receptor); Tumor suppressor Q05655 5580 3p21.1 human T141-p 1028305 EDEAKFPtMNRRGAI enzymatic activity, induced 19366211 2 9 1 +DCX Doublecortin iso2 Cytoskeletal; Motility/polarity/chemotaxis O43602-2 1641 Xq23 human T321-p 451361 TSSSQLStPKSKQSP intracellular localization cell motility, altered; cytoskeletal reorganization 14765123 3 0 2 affects doublecortin localization to growth cones, neurite outgrowth, and neuronal motility +Llgl1 LLGL1 Cell adhesion; Cytoskeletal; Motility/polarity/chemotaxis Q80Y17 16897 11 B2|11 37.81 cM mouse S650-p 449914 LAMEGPLsRVKSLKK intracellular localization 11809830 1 0 0 +TP53 p53 Activator; DNA-binding; Motility/polarity/chemotaxis; Nuclear receptor co-regulator; Transcription factor; Tumor suppressor P04637 7157 17p13.1 human S33-p 447531 LPENNVLsPLPSQAM activity, induced; protein degradation; acetylation; protein stabilization; molecular association, regulation; ubiquitination; phosphorylation cell cycle regulation; carcinogenesis, induced; apoptosis, induced; transcription, induced; transcription, altered; DNA repair, induced; cell growth, induced; apoptosis, inhibited; cell growth, altered FBXW7(INDUCES); S100B(INDUCES); S100A1(INDUCES); S100A4(INDUCES); PIN1(INDUCES); CBP(INDUCES); S100A6(INDUCES); S100A2(INDUCES) DNA(INDUCES) 10581258; 11495913; 12397361; 12397362; 12860987; 14665630; 17906639; 17942552; 19251701; 19819244; 20962272; 21383696; 31940492; 35974003; 36923828; 9744860 35 3 0 +PXN PXN iso2 Adaptor/scaffold; Cell adhesion; Cytoskeletal; Motility/polarity/chemotaxis P49023-2 5829 12q24.23 human S178-p 448603 PPLPGALsPLYGVPE Paxillin protein stabilization; intracellular localization cytoskeletal reorganization; cell adhesion, altered 18818208 9 2 0 in response to E4orf4; Phosphorylated S178 recruits, retains, and stabilizes paxillin to focal adhesions. +PRMT8 PRMT8 EC 2.1.1.-; METHYLTRANSFERASE; Methyltransferase; Methyltransferase, protein arginine Q9NR22 56341 12p13.32 human R73-m2 2574938 NPEEMTSrDYYFDSY enzymatic activity, altered PRMT8(INDUCES) 17925405 1 1 0 automethylation +KLRF2 KLRF2 Membrane protein, integral D3W0D1 100431172 12p13.31 human Y7-p 62864300 _MENEDGyMTLSFKN activity, induced 28082678 1 0 0 +Sox2 SOX2 Cell development/differentiation; DNA-binding; Transcription factor P48432 20674 3 A3|3 16.93 cM mouse S39-p 18913847 TGGNQKNsPDRVKRP cell differentiation, inhibited 28584195 2 3 0 neuronal differentiation, neurogenic commitment during embryogenesis but only if S39 is dephosphorylated +KIF2C KIF2C Cancer Testis Antigen (CTA); Microtubule-binding; Motility/polarity/chemotaxis; Motor Q99661 11004 1p34.1 human S632-p 5829783 EELSSQMsSFNEAMT enzymatic activity, induced cell cycle regulation; cytoskeletal reorganization 25504441 1 2 1 1) Regulates catalytic activity of KIF2C 2) Activates KIF2C during mitosis. 3) Phosphorylation is required for microtubule depolymerization and proper spindle assembly. 4) Prevention of S632/S633 phosphorylation leads to chromosome segregation defects in anaphase. +Marcksl1 MLP Cell cycle regulation P28667 17357 4 D2.2|4 63.26 cM mouse S93-p 477961 PKKKKKFsFKKPFKL MARCKS intracellular localization cytoskeletal reorganization 21602810 1 17 75 +Sox9 SOX9 DNA-binding; Transcription factor Q04887 20682 11 E2|11 77.27 cM mouse S492-p 1877718900 PSIPQTHsPQHWEQP protein degradation; molecular association, regulation cell differentiation, inhibited; transcription, altered SMAD3(DISRUPTS) 35803931 1 1 0 +ADRB2 ADRB2 GPCR, family 1; Membrane protein, integral; Membrane protein, multi-pass; Receptor, GPCR P07550 154 5q32 human S364-p 458915 NGNTGEQsGYHVEQE molecular association, regulation; receptor desensitization, altered; receptor internalization, altered ARR3(INDUCES); ARRB2(INDUCES) 11040066; 16407241; 18801735; 22275358 5 0 0 +GRK2 GRK2 EC 2.7.11.15; KINASE; Kinase, protein; Protein kinase, AGC; Protein kinase, Ser/Thr (non-receptor) P25098 156 11q13.2 human K31-ub 573762708 PAARASKkILLPEPS protein degradation 17006543 1 2 0 +NBN NBS1 Cell cycle regulation; DNA repair, damage O60934 4683 8q21.3 human K715-ac 487516 LIAHHARkNTELEEW Nbs1_C phosphorylation cell cycle regulation; apoptosis, induced 17612497 2 1 0 inhibits phosphorylation at S343 +DRD2 DRD2 iso2 GPCR, family 1; Membrane protein, integral; Membrane protein, multi-pass; Receptor, GPCR P14416-2 1813 11q23.2 human T134-p 13315301 AISIDRYtAVAMPML 7tm_1 receptor desensitization, induced 23082996 2 0 0 PKC mediated receptor desensitization +LAT LAT Adaptor/scaffold; Membrane protein, integral O43561 27040 16p11.2 human Y161-p 447760 DDYHNPGyLVVLPDS LAT molecular association, regulation PLCG1(INDUCES) 10811803 24 1 1 +INVS INVS Q9Y283 27130 9q31.1 human T864-p 55578722 SGARRLEtSTLSEDF cytoskeletal reorganization 27220846 1 0 0 Akt2 plays a more prominent role in ciliary development than Akt1, tubular differentiation +PLD2 PLD2 EC 3.1.4.4; Lipid Metabolism - ether lipid; Lipid Metabolism - glycerophospholipid; Motility/polarity/chemotaxis; Phospholipase O14939 5338 17p13.2 human T252-p 456498 LLYMCLEtGAISFVQ enzymatic activity, induced 15979581 1 1 0 +Mff MFF Membrane protein, integral; Mitochondrial Q6PCP5 75734 1|1 C5 mouse S146-p 484865 GQLVRNDsIVTPSPP Miff molecular association, regulation carcinogenesis, inhibited; autophagy, induced; cell growth, inhibited; signaling pathway regulation DRP1(INDUCES) 31693892; 36481655 6 54 13 +SNRPB snRNP B1 RNA processing; RNA splicing; RNA-binding; Spliceosome P14678 6628 20p13 human R147-m2 476756 QVMTPQGrGTVAAAA molecular association, regulation SMN(INDUCES) 11720283 1 4 0 +PKM PKM Carbohydrate Metabolism - glycolysis and gluconeogenesis; Carbohydrate Metabolism - pyruvate; EC 2.7.1.40; KINASE; Kinase, other; Mitochondrial; Nucleotide Metabolism - purine P14618 5315 15q23 human Y148-p 454768 KITLDNAyMEKCDEN PK enzymatic activity, inhibited cell growth, induced 26759242 3 28 321 +NOVA2 NOVA2 Q9UNW9 4858 19q13.32 human S25-p 1869341901 EVVCTKRsNTGEEGE intracellular localization 32492405 1 1 0 Phosphorylated NOVA2 translocates to cytosol leading to reduced E29 inclusion in BK channel and thereby inhibiting BK channel activity. +HNRNPUL1 E1B-AP5 RNA splicing; RNA-binding Q9BUJ2 11100 19q13.2 human R639-m1 12191845 RGPPGGNrGGFQNRG molecular association, regulation; intracellular localization NBS1(INDUCES) 26020839 1 4 14 ecruitment at sites of damage +Dixdc1 DIXDC1 Cell adhesion; Cell development/differentiation Q80Y83 330938 9|9 A5.3 mouse S250-p 15714601 CSSLTSPsPIHSAKS molecular association, regulation cell motility, altered; cytoskeletal reorganization NDEL1(INDUCES) 20624590 1 4 0 DIXDC1/NDEL1/DISC1 complex +Caskin1 CASKIN1 Adaptor/scaffold Q8VHK2 140722 10q12 rat Y296-p 472784 TKDYCNNyDLTSLNV SH3_2 protein conformation 23181695 1 2 28 Phosphorylation leads to structural changes in the SH3 domain. +MAP3K7 TAK1 EC 2.7.11.25; KINASE; Kinase, protein; Protein kinase, Ser/Thr (non-receptor); Protein kinase, TKL O43318 6885 6q15 human S439-p 455196 NGQPRRRsIQDLTVT molecular association, regulation IKKG(INDUCES) 29511289 9 83 63 +Dpysl2 CRMP-2 Microtubule-binding; Motility/polarity/chemotaxis O08553 12934 14 D1|14 34.6 cM mouse K374-sm 31094501 DKAVVTGkMDENQFV Amidohydro_1 activity, induced; sumoylation; intracellular localization signaling pathway regulation 23510938; 23836888; 28277940; 34757807 6 0 0 decreases calcium influx, CRMP2/CaV2.2 signaling pathway; CRMP-2 K374A mutant or compound 194 decreased SUMOylation NaV1.7 currents in sensory neurons across species +MARCKS MARCKS Actin-binding; Motility/polarity/chemotaxis P12624 613548 cow S169-p 451837 SFKLSGFsFKKNKKE MARCKS exocytosis, induced 22013076 11 76 93 Calcium mobilization, degranulation induced and dissociation of MARCK5 from plasma membrane. +TEX14 TEX14 Cancer Testis Antigen (CTA); KINASE; Kinase, protein; Protein kinase, Other; Protein kinase, Ser/Thr (non-receptor) Q8IWB6 56155 17q22 human T727-p 25158903 SNLNNMStTEEYLIS molecular association, regulation; intracellular localization PLK1(INDUCES) 22405274 1 0 0 +GRIN2B NMDAR2B Channel, calcium; Channel, ligand-gated; Membrane protein, integral; Membrane protein, multi-pass Q13224 2904 12p13.1 human S1415-p 1874095504 QPTVAGAsKARPDFR NMDAR2_C activity, induced 34252035 1 1 0 +Tp63 p63 DNA-binding; Transcription factor O88898 22061 16 B1|16 17.37 cM mouse S41-p 27937106 SYYRSAMsQSTQTSE transcription, induced 24366874 1 0 0 induces REDD1 expression +STK16 MPSK1 EC 2.7.10.2; EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, Other; Protein kinase, Ser/Thr (non-receptor); Protein kinase, tyrosine (non-receptor) O75716 8576 2q35 human Y198-p 2028407 AQRCTISyRAPELFS Pkinase intracellular localization; phosphorylation; enzymatic activity, induced cell cycle regulation 31574902 2 0 0 decrease 4EBP1 phosphorylation by Y198 mutation +HMGCR HMGCR EC 1.1.1.34; Endoplasmic reticulum; Membrane protein, integral; Membrane protein, multi-pass; Motility/polarity/chemotaxis; Oxidoreductase; Secondary Metabolites Metabolism - terpenoid backbone biosynthesis P04035 3156 5q13.3 human K248-ub 10844794 VLEEEENkPNPVTQR protein degradation; ubiquitination 20458442; 31323021 3 8 25 mutationsdid not reduce sterol-induced degradation of HMGCR, Ubiad1 (WT) or Ubiad1 (G184R) did not increase the amount of mutant HMGCR (K89R, K248R) +KMT2A MLL Cell cycle regulation; EC 2.1.1.43; METHYLTRANSFERASE; Methyltransferase; Methyltransferase, protein lysine; Oncoprotein; Transcription factor Q03164 4297 11q23.3 human S516-p 4709074 VHPPLPIsQSPENES protein stabilization; molecular association, regulation; intracellular localization cell cycle regulation SKP2(DISRUPTS) 20818375 1 2 0 accumulates on chromatin +SLC6A6 TAUT Membrane protein, integral; Membrane protein, multi-pass; Transporter; Transporter, SLC family Q00589 404000 dog S322-p 450688 YNKYKYNsYRDCMLL SNF activity, inhibited 10477138 1 0 0 Taurine transport mediated by the S322A mutant was increased 3-fold as compared with the wild-type molecule +CASP8AP2 CASP8AP2 Apoptosis; Nuclear receptor co-regulator Q9UKL3 9994 6q15 human K1813-sm 8474900 EVKKDELkSEPGSNC transcription, induced 19615980 1 0 0 K1813R mutant coexpressed with SENP1 +Itpr1 IP3R1 Channel, calcium; Channel, ligand-gated; Membrane protein, integral; Membrane protein, multi-pass P29994 25262 4q41 rat T945-p 3635217 GGGFLPMtPMAAAPE molecular association, regulation 22878752 1 3 11 T945 phosphorylation reduces IP3 binding affiinity and Ca2+ release is reduced. +TCF3 E2A Cell development/differentiation; DNA-binding; Oncoprotein; Transcription factor P15923 6929 19p13.3 human S39-p 15500103 NGKGRPAsLAGAQFG intracellular localization cell motility, induced; cell adhesion, inhibited 26212009 1 2 1 colon cancer metastasis, importing into the nucleus, promotes epithelial mesenchymal transition +Hcn2 HCN2 Channel, cation; Membrane protein, integral; Membrane protein, multi-pass O88703 15166 10|10 C1 mouse S641-p 18454000 DRIGKKNsILLHKVQ activity, inhibited 21347269 1 1 0 +Opn4 melanopsin GPCR, family 1; Membrane protein, integral; Membrane protein, multi-pass; Receptor, GPCR Q9QXZ9 30044 14|14 B mouse S392-p 1868515102 THRSTLSsQSSDLSW molecular association, regulation; protein conformation ARRB1(INDUCES) 32236094 1 1 0 +PAK2 PAK2 EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, STE; Protein kinase, Ser/Thr (non-receptor) Q13177 5062 3q29 human S20-p 448298 APPVRMSsTIFSTGG carcinogenesis, induced; cell growth, induced 26218748; 31969394 8 11 100 +DUSP10 DUSP10 EC 3.1.3.16; EC 3.1.3.48; Motility/polarity/chemotaxis; PHOSPHATASE; Protein phosphatase, dual-specificity Q9Y6W6 11221 1q41 human S224-p 38520204 SCREGKDsFKRIFSK Rhodanese cell growth, inhibited; apoptosis, induced 25568665 1 0 0 +Jak2 JAK2 EC 2.7.10.2; KINASE; Kinase, protein; Oncoprotein; Protein kinase, TK; Protein kinase, tyrosine (non-receptor) Q62120 16452 19 C1|19 23.73 cM mouse Y613-p 1811800 HKHLVLNyGVCVCGE PK_Tyr_Ser-Thr enzymatic activity, induced 18160720 1 0 0 Y613E mutant shows constitutive activation of Jak2, which depends on the presence of EpoR +Vcl Vinculin Cell adhesion; Cytoskeletal; Motility/polarity/chemotaxis Q64727 22330 14 A3|14 11.53 cM mouse S721-p 3181157 DEAIDTKsLLDASEE Vinculin molecular association, regulation; protein conformation; activity, inhibited apoptosis, induced CTNNB1(DISRUPTS); CTNNA1(DISRUPTS); CDH5(DISRUPTS) 36380599 1 50 0 +C16orf74 C16orf74 Q96GX8 404550 16q24.1 human T44-p 3209115 DIIITPPtPTGMMLP DUF4597 molecular association, regulation cell motility, induced PPP3CA(INDUCES) 28881575 1 14 15 PDAC cell invasion +RIOK2 RIOK2 EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, Ser/Thr (non-receptor); Protein kinase, atypical Q9BVS4 55781 5q15 human S548-p 21241902 KSSLEAAsFWGE___ cell cycle regulation 21880710 1 1 0 +Oprm1 MOR-1 GPCR, family 1; Membrane protein, integral; Membrane protein, multi-pass; Receptor, GPCR P33535 25601 1q11 rat S261-p 447781 LMILRLKsVRMLSGS 7tm_1 receptor desensitization, altered MOR-1(NOT_REPORTED) 9326307 2 0 2 +STK4 MST1 Autophagy; EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, STE; Protein kinase, Ser/Thr (non-receptor) Q13043 6789 20q13.12 human T387-p 450050 TMKRRDEtMQPAKPS protein stabilization; intracellular localization; enzymatic activity, inhibited; enzymatic activity, induced; phosphorylation apoptosis, altered; apoptosis, inhibited 17726016; 20513427; 34348155 6 2 7 +Pdzrn3 PDZRN3 EC 6.3.2.-; Ligase; UBIQUITIN LIGASE; Ubiquitin conjugating system; Ubiquitin ligase Q69ZS0 55983 6|6 D3 mouse T955-p 25304555 REERSGLtTDDDAMS protein degradation cell motility, inhibited 34135125 1 4 2 +Sox9 SOX9 DNA-binding; Transcription factor Q04887 20682 11 E2|11 77.27 cM mouse S64-p 451039 EPDLKKEsEEDKFPV Sox_N activity, induced transcription, altered 19113914 6 0 0 promotes expression of osteochondrogenic markers +MCL1 MCL1 Apoptosis; Channel, misc.; Inhibitor; Membrane protein, integral; Mitochondrial Q07820 4170 1q21.2 human S121-p 1172400 PAADAIMsPEEELDG protein degradation; protein stabilization; molecular association, regulation; ubiquitination cell cycle regulation; carcinogenesis, inhibited; apoptosis, induced FBXW7(INDUCES) 12223490; 21368833; 21368834; 26205817; 27738316 7 4 0 +GRK1 GRK1 EC 2.7.11.14; KINASE; Kinase, protein; Protein kinase, AGC; Protein kinase, Ser/Thr (non-receptor) Q15835 6011 13q34 human S491-p 2530401 IQDVGAFsTVKGVAF molecular association, regulation Rhodopsin(INDUCES) 34262173 3 1 0 +Cldn16 Claudin-16 Cell adhesion; Membrane protein, integral; Membrane protein, multi-pass Q91Y55 155268 11q22 rat T233-p 11555106 AKMYAVDtRV_____ intracellular localization 19914201 2 0 0 +Arhgef2 ARHGEF2 GEF; GEF, Rac/Rho; Motility/polarity/chemotaxis Q60875 16800 3|3 F1 mouse S143-p 10991696 GSRRGLSsLSLAKSV molecular association, regulation; intracellular localization cytoskeletal reorganization DYNLT1(DISRUPTS) 22405273 2 7 4 reduced microtubule localization in S143D mutnt +Syk Syk EC 2.7.10.2; KINASE; Kinase, protein; Protein kinase, TK; Protein kinase, tyrosine (non-receptor) P48025 20963 13 A5|13 27.41 cM mouse Y342-p 447659 LPMDTEVyESPYADP molecular association, regulation; phosphorylation; enzymatic activity, induced endocytosis, altered; cell motility, altered; cell adhesion, altered; signaling pathway regulation FGR(INDUCES) 11672534; 12077122; 15536084; 15576379; 27609517; 35753354 15 12 112 Mutant Y342F/346F Syc showed less efficient FcERI-induced degranulation, and delayed calcium influx. ; induces AKT/ERK phosphorylation and GPVI-mediated signaling; AKT phosphorylation +LRRK2 LRRK2 EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, Ser/Thr (non-receptor); Protein kinase, TKL Q5S007 120892 12q12 human Y2018-p 1873559812 IIAKIADyGIAQYCC Pkinase phosphorylation 34088839 1 0 0 LRRK2 fragment (aa1327-2527) carrying mutation Y2018F increases phosphorylation of Rab8a in vitro +Brsk2 BRSK2 EC 2.7.11.1; EC 2.7.11.26; KINASE; Kinase, protein; Protein kinase, CAMK; Protein kinase, Ser/Thr (non-receptor) Q69Z98 75770 7|7 F5 mouse T502-p 17554455 RRKLQVPtPEEMSNL protein stabilization; enzymatic activity, inhibited; phosphorylation 23790753 1 1 0 inhibits axon branching (activated in BRSK2 18A mutant) +SKA3 SKA3 Cell cycle regulation Q8IX90 221150 13q12.11 human S283-p 31863083 SDAEYTNsPLVPTFC molecular association, regulation; intracellular localization cell cycle regulation; chromatin organization, altered; cytoskeletal reorganization HEC1(INDUCES) 32491969 1 4 0 +HES1 HES1 Cell development/differentiation; Motility/polarity/chemotaxis; Transcription factor Q14469 3280 3q29 human S38-p 3882731 ASEHRKSsKPIMEKR HLH molecular association, regulation cytoskeletal reorganization; transcription, altered DNA(DISRUPTS) 9389649 1 0 1 in vivo neurite outgrowth +Zap70 ZAP70 EC 2.7.10.2; KINASE; Kinase, protein; Protein kinase, TK; Protein kinase, tyrosine (non-receptor) P43404 22637 1 B|1 15.41 cM mouse K552-ub 1877703500 PEVLDFIkQGKRMEC PK_Tyr_Ser-Thr protein degradation 31061531 1 1 0 +Sp1 SP1 C2H2-type zinc finger protein; DNA-binding; Transcription factor O89090 20683 15|15 F3 mouse S493-gl 4283200 LAPMQGVsLGQTSSS molecular association, regulation transcription, inhibited Oct1(DISRUPTS) DNA(DISRUPTS) 19070619 3 1 0 inhibits the Sp1?Oct1 cooperative activation of the U2 snRNA promoter +Cdkn1b p27Kip1 Cell cycle regulation; Inhibitor; Oncoprotein; Protein kinase, regulatory subunit P46414 12576 6 G1|6 65.77 cM mouse S10-p 447874 NVRVSNGsPSLERMD protein stabilization; intracellular localization cell cycle regulation; cell growth, induced; cell growth, altered CCNA1(DISRUPTS); CCNE1(DISRUPTS); CCND1(DISRUPTS) 15010468; 15528185; 16391232; 20810788; 20837141; 21317921 47 36 1 interaction is in vivo, not in vitro (due to localization); neurite outgrowth +TOP1 TOP1 EC 5.99.1.2; Isomerase; Nucleolus; Oncoprotein P11387 7150 20q12 human K153-sm 2793909 DYKPKKIkTEDTKKE molecular association, regulation; intracellular localization apoptosis, induced DNA(INDUCES) 12149243; 12439742 3 2 0 increase in CPT-induced apoptosis; enhances TOPO1-DNA cleavable complex formation induced by CPT +EHD3 EHD3 Q9NZN3 30845 2p23.1 human K511-sm 49176401 ANHLIKVkLEGHELP EF-hand_4 receptor recycling, induced; intracellular localization endocytosis, altered 26226295 1 0 0 tubulation of the endocytic recycling compartment (ERC) membranes and efficient recycling +MAP3K7 TAK1 EC 2.7.11.25; KINASE; Kinase, protein; Protein kinase, Ser/Thr (non-receptor); Protein kinase, TKL O43318 6885 6q15 human T444-p 7444663 RRSIQDLtVTGTEPG molecular association, regulation IKKG(INDUCES) 29511289 1 6 0 +Apbb1 Fe65 Adaptor/scaffold; Apoptosis; Transcription regulation Q9QXJ1 11785 7 E3|7 55.9 cM mouse Y547-p 451143 VQKFQVYyLGNVPVA PID transcription, induced 15031292 2 1 0 +APBB1 Fe65 Adaptor/scaffold; Apoptosis; Transcription regulation O00213 322 11p15.4 human K701-ac 1881304500 QSLWGSLkPKRLGAH transcription, induced 33938178 1 0 0 +DES desmin Cytoskeletal; Motility/polarity/chemotaxis P17661 1674 2q35 human T76-p 449615 LRASRLGtTRTPSSY Filament_head cytoskeletal reorganization 12686604 1 0 0 Mutated desmin sites showed failure of desmin filaments to segregate into daughter cells. +WDR62 WDR62 Adaptor/scaffold O43379 284403 19q13.12 human S52-p 3175154 RTRLSTAsEETVQNR cell cycle regulation 26713495 2 11 33 WDR62 regulation of the mitotic spindle +TXNIP TXNIP Apoptosis; Mitochondrial; Motility/polarity/chemotaxis; Tumor suppressor Q9H3M7 10628 1q21.1 human S308-p 277409200 GLSSRTSsMASRTSS protein degradation 23453806 2 0 0 +AKT1 Akt1 EC 2.7.11.1; KINASE; Kinase, protein; Oncoprotein; Protein kinase, AGC; Protein kinase, Ser/Thr (non-receptor) P31749 207 14q32.33 human K64-sm 1881330701 VAQCQLMkTERPRPN phosphorylation; enzymatic activity, induced neural plasticity; signaling pathway regulation 34288124 1 0 0 Sumoylation at K64 and K276 increases T308 phosphorylation upregulates kinase activity.activates ERK-Elk-1Arc/BDNF and mTOR-P70S6k-4E-BP1 signaling, hippocampal LTP regulation +Mapk1 ERK2 EC 2.7.11.24; KINASE; Kinase, protein; Protein kinase, CMGC; Protein kinase, Ser/Thr (non-receptor) P63086 116590 11q23 rat T188-p 3949250 FLTEYVAtRWYRAPE Pkinase enzymatic activity, induced 26658610 4 17 17 +FANCD2 FANCD2 DNA repair, damage Q9BXW9 2177 3p25.3 human S886-p 31867427 TSSSDTLsEEKNSEC FancD2 molecular association, regulation; ubiquitination; intracellular localization; activity, inhibited cell cycle regulation; DNA repair, inhibited; signaling pathway regulation DNA(DISRUPTS) 31167143 1 3 0 inhibits Fanconi anemia pathway leading to inhibition of DNA repair; 882-898 cluster +Pag1 PAG Adaptor/scaffold; Membrane protein, integral Q9JM80 64019 2q23 rat Y183-p 454746 NMVEDCLyETVKEIK PAG cell growth, altered 18498747 2 22 115 +TERT TERT DNA-binding; EC 2.7.7.49; Nucleolus; Transferase O14746 7015 5p15.33 human S824-p 11418801 AVRIRGKsYVQCQGI RVT_1 intracellular localization; enzymatic activity, induced 10224060; 22902867 2 0 0 +DDX17 DDX17 iso3 EC 3.6.4.13; Helicase; Nuclear receptor co-regulator; Nucleolus; RNA processing; RNA-binding; Spliceosome; Transcription, coactivator/corepressor Q92841-3 10521 22q13.1 human K30-ac 15211506 GGGLPPKkFGNPGER protein stabilization; molecular association, regulation cell cycle regulation; apoptosis, inhibited HDAC3(INDUCES); HDAC1(INDUCES) 20663877 1 1 13 +SAV1 SAV1 Adaptor/scaffold Q9H4B6 60485 14q22.1 human S27-p 7447103 KYVKKETsPLLRNLM protein conformation apoptosis, induced 21944251 1 8 0 self-dimerization; increase in protein level +FRS2 FRS2 Adaptor/scaffold Q8WU20 10818 12q15 human Y471-p 473102 PTRRTELyAVIDIER molecular association, regulation cell differentiation, induced SHP-2(INDUCES) 11278583 2 2 15 +Ncoa3 SRC-3 ACETYLTRANSFERASE; Acetyltransferase; EC 2.3.1.48; Motility/polarity/chemotaxis; Nuclear receptor co-regulator; Transcription, coactivator/corepressor O09000 17979 2|2 H3 mouse R839-me 2363406 PQPVQSVrPPYNRAV protein degradation transcription, inhibited CBP(INDUCES) 17043108 1 0 0 +Sox9 SOX9 DNA-binding; Transcription factor Q04887 20682 11 E2|11 77.27 cM mouse R74-me 10338208 DKFPVCIrEAVSQVL Sox_N molecular association, regulation cell cycle regulation; cell growth, induced; transcription, induced CTNNB1(DISRUPTS) 19725955 1 0 0 promotes cyclin D1 expression, regulates endochondral ossification, chondrocyte/cartilage development during embryogenesis +CACB CACNA1C Channel, calcium; Membrane protein, integral; Membrane protein, multi-pass P15381 100101555 rabbit S1700-p 4714250 PEIRRAIsGDLTAEE CAC1F_C activity, induced 20876873; 36215501 17 7 0 induces CaV1.2 activity; regulates basal activity of CACNA1C channels; required for stimulation of CACNA1C channels activity +RAF1 RAF1 EC 2.7.11.1; KINASE; Kinase, protein; Oncoprotein; Protein kinase, Ser/Thr (non-receptor); Protein kinase, TKL P04049 5894 3p25.2 human T269-p 447747 NVHMVSTtLPVDSRM enzymatic activity, induced 11134016; 7477354; 9094715 5 0 0 +Ulk1 ULK1 Autophagy; EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, Other; Protein kinase, Ser/Thr (non-receptor) O70405 22241 5|5 F mouse S991-p 1869357208 HAVQMVQsAALDEMF DUF3543 cell cycle regulation; autophagy, induced; cell growth, induced 32516310 1 0 0 +PDGFRA PDGFRA EC 2.7.10.1; KINASE; Kinase, protein; Membrane protein, integral; Oncoprotein; Protein kinase, TK; Protein kinase, tyrosine (receptor) P16234 5156 4q12 human Y742-p 448657 KQADTTQyVPMLERK PK_Tyr_Ser-Thr molecular association, regulation PIK3R1(INDUCES) 11818394 2 11 102 +Ikbkb IKKB EC 2.7.11.10; KINASE; Kinase, protein; Protein kinase, Other; Protein kinase, Ser/Thr (non-receptor) O88351 16150 8|8 A2 mouse S679-p 5735027 SPDSMNVsRLSHPGQ molecular association, regulation; phosphorylation PPP2R3C(INDUCES) 20925653 1 5 0 interaction with PPP2R3C (aka G4-1) downregulates IKK-beta activity; S181 phosphorylation increased in S679/682/689/692/697/701/705A mutant +PPP1R12A MYPT1 Motility/polarity/chemotaxis; PHOSPHATASE; Protein phosphatase, regulatory subunit O14974 4659 12q21.2-q21.31 human S910-p 1983104 SLLGRSGsYSYLEER cell adhesion, altered 20354225 3 43 60 +MCM3 MCM3 DNA replication; EC 3.6.4.12 P25205 4172 6p12.2 human K748-ub 22247293 ESRLKAFkVALLDVF cell cycle regulation 27621311 1 2 0 KEAP1-MCM3 associates with chromatin in a cell cycle-dependent manner +DNMT1 DNMT1 Amino Acid Metabolism - cysteine and methionine; Cell development/differentiation; EC 2.1.1.37; METHYLTRANSFERASE; Methyltransferase; Methyltransferase, DNA; Transcription regulation P26358 1786 19p13.2 human K957-sm 12726306 IKLSSPVkRPRKEPV BAH enzymatic activity, induced DNA(INDUCES) 19450230 1 0 0 +Pdpk1 PDK1 EC 2.7.11.1; KINASE; Kinase, protein; Nuclear receptor co-regulator; Protein kinase, AGC; Protein kinase, Ser/Thr (non-receptor) O55173 81745 10q12 rat S244-p 447693 SKQARANsFVGTAQY Pkinase enzymatic activity, induced 11570885 63 95 264 +INSR INSR EC 2.7.10.1; KINASE; Kinase, protein; Membrane protein, integral; Protein kinase, TK; Protein kinase, tyrosine (receptor) P06213 3643 19p13.2 human Y1189-p 447681 RDIYETDyYRKGGKG PK_Tyr_Ser-Thr molecular association, regulation; receptor internalization, altered; enzymatic activity, induced signaling pathway regulation; transcription, altered IRS2(INDUCES); APS(INDUCES); PTP1B(INDUCES) 10852715; 11850117; 14690593; 1658004; 22081023; 34208786; 8024702; 8999839; 9195949 52 36 707 prolactin transcription; insulin pathway regulation +AR AR DNA-binding; Nuclear receptor; Transcription factor P10275 367 Xq12 human K634-ac 458904 LGARKLKkLGNLKLQ activity, induced; protein stabilization; molecular association, regulation; phosphorylation carcinogenesis, inhibited; apoptosis, induced; transcription, induced; transcription, altered; signaling pathway regulation p300(INDUCES) 11971970; 11994312; 15123687; 16860317; 17483368; 18022799; 22131404 7 0 0 has differential effect on different promoters; limits transcriptional activity +WNK4 WNK4 EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, Other; Protein kinase, Ser/Thr (non-receptor) Q96J92 65266 17q21.2 human S1190-p 477191 SSRQRRLsKGSFPTS activity, induced; phosphorylation 23054253; 23673010 6 4 0 inhibits phosphorylation at S1201; BK channel activity induced; regulates NKCC2 activity +DLC1 DLC1 GAP; GAP, Rac/Rho; Tumor suppressor Q96QB1 10395 8p22 human S766-p 458383 VTRTRSLsACNKRVG molecular association, regulation; intracellular localization; protein conformation; activity, inhibited cell growth, induced RHOA(DISRUPTS); DLC1(INDUCES) 29114068 2 3 1 greatly attenuates its RhoGAP and tumor-suppressor functions; becomes monomer; alters its focal adhesion (FA) localization +SNCA SNCA Adaptor/scaffold P37840 6622 4q22.1 human K45-ub 1877722303 LYVGSKTkEGVVHGV Synuclein protein degradation; ubiquitination 31167929 1 1 0 ubiquitination and degradation of internalized SNCA fibrils +Ppp1r3a PPP1R3A Membrane protein, integral; Protein phosphatase, regulatory subunit D3ZM60 500036 4q21 rat S67-p 449321 TSASRRVsFADSLGF activity, inhibited 10973812 6 1 0 inhibits glycogen synthase activity +TBX21 TBX21 DNA-binding; Transcription factor Q9UL17 30009 17q21.32 human Y220-p 20583307 SMPGNRLyVHPDSPN T-box molecular association, regulation cell differentiation, altered; cell growth, induced; transcription, induced DNA(INDUCES) 21690296 1 0 0 +RPS3 RPS3 Apoptosis; EC 4.2.99.18; RNA-binding; Ribosomal; Translation P23396 6188 11q13.4 human S209-p 9765788 KPLPDHVsIVEPKDE intracellular localization 21399639 1 8 0 +ARHGEF9 ARHGEF9 GAP; GAP, Rac/Rho O43307 23229 Xq11.1 human K516-ub 1873595604 SRLTPFKk_______ protein degradation 29069083 1 0 0 regulates gephyrin clustering and dendritic arborization +Eif4g1 eIF4G RNA-binding; Translation; Translation initiation Q6NZJ6 208643 16|16 B1 mouse R689-m1 6009525 LSNRGPPrGGPGGEL protein stabilization translation, induced 28655788 1 6 61 +LAX1 LAX1 Adaptor/scaffold; Membrane protein, integral Q8IWV1 54900 1q32.1 human Y373-p 460158 SNEDSSDyENVLTAK LAX molecular association, regulation transcription, inhibited; signaling pathway regulation GRB2(INDUCES); GADS(INDUCES); PIK3R1(INDUCES) 12359715 1 5 69 +FOXM1 FOXM1 DNA-binding; Transcription factor Q08050 2305 12p13.33 human T627-p 3194576 TPESWRLtPPAKVGG protein stabilization transcription, induced 22094256 1 6 5 +Ctla4 CTLA-4 Immunoglobulin superfamily; Membrane protein, integral P09793 12477 1 C2|1 30.58 cM mouse Y201-p 450897 SPLTTGVyVKMPPTE molecular association, regulation; receptor internalization, altered; intracellular localization JAK2(INDUCES); SHP-2(INDUCES) 10842319; 24648182; 9973379 5 0 1 Phosphorylation of Y201 in Jurkat cells correlated with cell surface accumulation of CTLA-4.; increases surface level expression, Treg-cell function, increased IL-4 production, increased FoxP3 expression +CITED2 CITED2 Apoptosis; Cell cycle regulation; Motility/polarity/chemotaxis; Nuclear receptor co-regulator; Transcription, coactivator/corepressor Q99967 10370 6q24.1 human T166-p 27145810 KHSGGSStPGGSGGS CITED transcription, induced 23082118 1 0 0 +ARHGDIA RhoGDI alpha Apoptosis; Cell adhesion; Cell development/differentiation; G protein regulator, misc.; Motility/polarity/chemotaxis P52565 396 17q25.3 human S101-p 452195 LESFKKQsFVLKEGV Rho_GDI molecular association, regulation; enzymatic activity, inhibited; phosphorylation RAC1(DISRUPTS); RhoGDI alpha(INDUCES); CDC42 iso1(DISRUPTS) 20028975; 24820414; 32003021 6 11 1 affects phosphorylation of RhoGDI alpha S174; regulate the local accumulation of active Rac1 +GSN Gelsolin iso3 Actin-binding; Motility/polarity/chemotaxis; Nuclear receptor co-regulator; Secreted; Secreted, signal peptide P06396-3 2934 9q33.2 human Y438-p 23109545 GDSYIILyNYRHGGR Gelsolin protein stabilization; activity, inhibited cell motility, induced; cytoskeletal reorganization 23791551 1 0 1 +SNAI1 Snail1 C2H2-type zinc finger protein; Transcription factor O95863 6615 20q13.13 human S100-p 6097704 DEDSGKGsQPPSPPS protein degradation; ubiquitination; intracellular localization cell motility, altered; transcription, altered FBW1B(INDUCES) 15448698; 19004823 4 0 0 Localization mediated by S107, S111, S115 and S119. +LMNB2 Lamin B2 Cytoskeletal; Motility/polarity/chemotaxis P14732 chicken S410-p 20657002 SSTSLVRsSRGKRRR intracellular localization 8449977 1 0 0 nuclear uptake inhibited in vitro +CSNK2A1 CK2A1 EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, Other; Protein kinase, Ser/Thr (non-receptor) P68400 1457 20p13 human K102-ac 11322071 ITLADIVkDPVSRTP Pkinase enzymatic activity, induced 20608637 1 3 0 +Cacnb1 CACNB1 Channel, calcium P54283 50688 10q31 rat S161-p 459045 CEVGFIPsPVKLDSL activity, induced 16406008 1 0 0 +KAT2A GCN5 ACETYLTRANSFERASE; Acetyltransferase; EC 2.3.1.48 Q92830 2648 17q21.2 human S307-p 27421701 HVPQSCDsLPRYETT PCAF_N acetylation; enzymatic activity, induced transcription, altered 23142079 1 1 0 direct opposition to Sirt1; increases PGC-1a acetylation; Regulates the gluconeogenic transcriptional response of fasted mice +KCNMA1 KCNMA1 Channel, potassium; Endoplasmic reticulum; Membrane protein, integral; Membrane protein, multi-pass Q12791 3778 10q22.3 human S1200-p 9805700 SHSSQSSsKKSSSVH activity, induced 19592459 1 0 0 +Pou1f1 GHF-1 DNA-binding; Transcription factor P10037 25517 11p12 rat T220-p 451518 RKRKRRTtISIAAKD Homeodomain molecular association, regulation; activity, inhibited transcription, inhibited Ets-1(INDUCES) DNA(DISRUPTS) 12242337; 19887646; 8524234 3 0 0 Phosphorylation of T220 inhibits DNA-binding activity of GHF-1.; stimulates binding to dimeric, but not to monomeric GHF-1 sites in the rPRL promoter +MAP2K1 MEK1 EC 2.7.12.2; KINASE; Kinase, protein; Protein kinase, STE; Protein kinase, dual-specificity (non-receptor) Q02750 5604 15q22.31 human S298-p 448284 RTPGRPLsSYGMDSR Pkinase molecular association, regulation; protein conformation carcinogenesis, induced; cell motility, induced; apoptosis, inhibited; cell adhesion, induced; transcription, induced; signaling pathway regulation; cell growth, altered ERK1(INDUCES); Akt1(INDUCES); RAF1(INDUCES) 14993270; 17667937; 28225038; 33789117; 36319849; 9351825 25 4 1 Interaction with AKT induces FOXO1 phosphorylation; metastasis in nude mice ; induces the MAPK pathway; induces ERK pathway +Abca1 ABCA1 Membrane protein, integral; Membrane protein, multi-pass; Transporter; Transporter, ABC family; Vesicle P41233 11303 4 B2|4 28.57 cM mouse T1286-p 450308 QSCLHPFtEDDAVDP protein degradation; protein processing 12869555 1 0 0 Mutants showed increase of cell surface protein levels. ; T1286A and T1305A mutants are not degraded by calpain or stabilized by apoA-1. +NCAM1 NCAM1 Cell adhesion; Membrane protein, GPI anchor; Membrane protein, integral; Motility/polarity/chemotaxis P13591 4684 11q23.2 human Y744-p 454070 VVVDITCyFLNKCGL cell growth, altered 15313190 2 0 0 phosphorylation of this residue plays a role in the FGFR1- mediated cell signaling +POU2F1 Oct1 DNA-binding; Transcription factor P14859 5451 1q24.2 human S335-p 10424763 RFEALNLsFKNMCKL Pou transcription, inhibited 25937278 1 13 1 transcription of miR-451 in response to glucose availability +LGMN LGMN EC 3.4.22.34; Protease Q99538 5641 14q32.12 human S226-p 183811000 CYYDEKRsTYLGDWY Peptidase_C13 enzymatic activity, induced 28826672 1 0 0 AD Pathologies in Young 3xTg mice, stimulating cognitive dysfunction +NCOA3 SRC-3 ACETYLTRANSFERASE; Acetyltransferase; EC 2.3.1.48; Motility/polarity/chemotaxis; Nuclear receptor co-regulator; Transcription, coactivator/corepressor Q9Y6Q9 8202 20q13.12 human S601-p 7596700 SDKESKEsSVEGAEN protein stabilization transcription, induced 19339517 1 0 0 +Grm7 mGluR7 GPCR, family 3; Membrane protein, integral; Membrane protein, multi-pass; Receptor, GPCR P35400 81672 4q41 rat K889-sm 25042302 DRPNGEAkTELCENV sumoylation endocytosis, altered 26631532 2 0 0 +Lgmn LGMN EC 3.4.22.34; Protease O89017 19141 12|12 E mouse T324-p 23121345 LKRKLLRtNDVKESQ activity, inhibited neural plasticity; signaling pathway regulation 31004063; 34343610 2 0 1 +VIL1 Villin Actin-binding; Motility/polarity/chemotaxis P09327 7429 2q35 human Y286-p 469579 LLSHEDCyILDQGGL Gelsolin cell motility, altered; cytoskeletal reorganization 16921170 1 0 0 +CRYAB CRYAB Chaperone; Heat shock protein P02511 1410 11q23.1 human S59-p 448783 PSFLRAPsWFDTGLS activity, induced; molecular association, regulation; intracellular localization; protein conformation exocytosis, inhibited; apoptosis, inhibited CASP7(INDUCES); CRYAB(DISRUPTS); CASP3(INDUCES); GEMIN3(INDUCES); CASP2(DISRUPTS) 11096101; 15511225; 16129694; 16928191; 18061612; 23049853; 24023879; 26620801; 27641668; 36232565 46 22 0 +BIRC5 Survivin Apoptosis O15392 332 17q25.3 human T34-p 447705 FLEGCACtPERMAEA BIR activity, induced; protein stabilization; molecular association, regulation; intracellular localization carcinogenesis, induced; cell motility, induced; transcription, induced; signaling pathway regulation; apoptosis, inhibited; cytoskeletal reorganization; transcription, inhibited; cell growth, altered CASP9(INDUCES) 11069302; 11149963; 11861764; 12517802; 12529428; 15735703; 15894279; 16170024; 18949405; 24478433; 25468890; 32373497; 33211707; 33710603; 34034636 19 6 7 +Flt3 FLT3 EC 2.7.10.1; KINASE; Kinase, protein; Membrane protein, integral; Oncoprotein; Protein kinase, TK; Protein kinase, tyrosine (receptor) Q00342 14255 5 86.88 cM|5 G3 mouse Y592-p 448190 PLDNEYFyVDFRDYE enzymatic activity, induced 16091740 14 0 0 +Kcnq3 Kv7.3 iso2 Channel, potassium; Membrane protein, integral; Membrane protein, multi-pass O88944-2 29682 7q34 rat Y67-p 453408 VKRNNAKyRRIQTLI activity, inhibited 15304482 1 0 0 inhibition of K(+) current via reducing open probability. +AURKB AurB EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, Other; Protein kinase, Ser/Thr (non-receptor) Q96GD4 9212 17p13.1 human K56-ub 12365733 PTAAPGQkVMENSSG ubiquitination; intracellular localization 26766443 1 8 4 localization in prometaphase cells +Nos1 nNOS Amino Acid Metabolism - arginine and proline; EC 1.14.13.39; Oxidoreductase Q9Z0J4 18125 5 F|5 57.29 cM mouse S1412-p 449830 TNRLRSEsIAFIEES activity, induced; enzymatic activity, induced signaling pathway regulation 24498331; 33434144; 36084555 14 0 0 induces p38MAPK pathway and inhibits insulin pathway +KIF3A KIF3A Microtubule-binding; Motor Q9Y496 11127 5q31.1 human S687-p 454304 KTGRRKRsAKPETVI molecular association, regulation; intracellular localization exocytosis, inhibited TUBA1A(INDUCES) 24338362; 25878107 3 28 2 Cargo transport, Only the phosphorylated KIF3A motor will move along the microtubules.; decrease intracellular trafficking and cell surface expression of CD1d +FMR1 FMR1 Nucleolus; RNA-binding; Translation Q06787 2332 Xq27.3 human R546-me 4046001 RGQGGRGrGGGFKGN RNA splicing, altered 16922515 5 0 0 S500 phosphorylation has no affect on methylation; alternatively spliced variant of FMR1 exon 15, reduced methylation by more than 85% +Esr2 ER-beta DNA-binding; Nuclear receptor O08537 13983 12 C3|12 33.52 cM mouse S105-p 447914 LYAEPQKsPWCEARS ERbeta_N molecular association, regulation transcription, altered SRC-1(INDUCES) 10230404; 9058381 5 1 0 +PICK1 PICK1 Adaptor/scaffold; Cell development/differentiation; Ligand, receptor tyrosine kinase Q9NRD5 9463 22q13.1 human S342-p 25749628 QRLVSTMsKYYNDCY Arfaptin molecular association, regulation GluR2(INDUCES) 26472923 1 0 1 S415 was essential for binding to GluA2 +FEN1 FEN1 DNA repair, damage; DNA-binding; Deoxyribonuclease; EC 3.1.-.-; Nuclear receptor co-regulator; Nucleolus; Ribonuclease P39748 2237 11q12.2 human K377-m1 1873595100 TGAAGKFkRGK____ DNA repair, induced 29029401 1 0 0 +FURIN FURIN Cell surface; EC 3.4.21.75; Membrane protein, integral; Protease; Vesicle P09958 5045 15q26.1 human S773-p 469742 AWQEECPsDSEEDEG intracellular localization 8846780 2 10 0 retrieval to the trans-Golgi network +CHEK2 Chk2 EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, CAMK; Protein kinase, Ser/Thr (non-receptor); Tumor suppressor O96017 11200 22q12.1 human T389-p 981400 RTLCGTPtYLAPEVL Pkinase intracellular localization; phosphorylation 20713355 2 2 0 prerequisite for T387 phosphorylation; chromatin targeting of S372, S379, T389, singly and T383/389, T378/S379 +BAD BAD Apoptosis Q92934 572 11q13.1 human S99-p 447862 PFRGRSRsAPPNLWA Bcl-2_BAD activity, induced; molecular association, regulation; phosphorylation carcinogenesis, induced; apoptosis, altered; apoptosis, inhibited; transcription, inhibited; cell growth, altered 14-3-3 beta(INDUCES); 14-3-3 zeta(INDUCES); Bcl-2(DISRUPTS); Bcl-xL(DISRUPTS); 14-3-3 beta(DISRUPTS) 10611223; 10926925; 11085518; 12897059; 12970779; 15121878; 17670745; 18794113; 19667065; 20566643; 21419810; 21444773; 21849418; 22096607; 34418433; 35725817; 37363966 124 55 216 +KHDRBS1 KHDRBS1 RNA-binding Q07666 10657 1p35.2 human R315-m1 476772 PPRGALVrGTPVRGA intracellular localization 12529443 1 4 14 +Ntrk2 TrkB EC 2.7.10.1; KINASE; Kinase, protein; Membrane protein, integral; Protein kinase, TK; Protein kinase, tyrosine (receptor) P15209 18212 13 B1|13 31.2 cM mouse Y816-sn 1881005700 LAKASPVyLDILG__ protein degradation; molecular association, regulation; ubiquitination; intracellular localization; protein conformation; phosphorylation endocytosis, induced; signaling pathway regulation AP2M1(INDUCES); PLCG1(DISRUPTS) 36682419 1 0 0 decreases phosphorylation of itself, impairs BDNF signaling +NPHP1 NPHP1 Cell adhesion O15259 4867 2q13 human S123-p 26395107 EEEEESEsEDSEDSG molecular association, regulation; intracellular localization PACS-1(INDUCES) 16308564 1 0 0 +BRAF BRAF EC 2.7.11.1; KINASE; Kinase, protein; Oncoprotein; Protein kinase, Ser/Thr (non-receptor); Protein kinase, TKL P15056 673 7q34 human S151-p 478631 VARSNPKsPQKPIVR molecular association, regulation signaling pathway regulation; cell growth, altered NRas(DISRUPTS); RAF1(DISRUPTS) 19933846; 21478863 3 30 34 MAPK pathway +DDX5 DDX5 EC 3.6.4.13; Helicase; Nuclear receptor co-regulator; Nucleolus; RNA splicing; RNA-binding; Spliceosome P17844 1655 17q23.3 human R486-m2 27280653 GSGRSRGrGGMKDDR molecular association, regulation XRN2(INDUCES) 31267554 1 2 1 represses R-loops +Mgmt MGMT Apoptosis; DNA repair, damage; EC 2.1.1.63; METHYLTRANSFERASE; Methyltransferase; Nuclear receptor co-regulator P24528 25332 1q41 rat S204-p 31918701 KPSFESSsPKPSG__ protein stabilization 11104689 1 0 0 resistant to proteases in vitro which are increased during DEN-induced hepatocarcinogenesis +Bcr Bcr EC 2.7.11.1; GAP; GAP, Rac/Rho; GEF, Rac/Rho; KINASE; Kinase, protein; Oncoprotein; Protein kinase, Ser/Thr (non-receptor); Protein kinase, atypical Q6PAJ1 110279 10 C1|10 38.49 cM mouse S356-p 447791 SGQSSRVsPSPTTYR enzymatic activity, inhibited cell growth, altered 17934518 3 13 60 +PSEN1 PSEN1 Cell surface; EC 3.4.23.-; Membrane protein, integral; Membrane protein, multi-pass; Mitochondrial; Protease P49768 5663 14q24.2 human T354-p 451669 HLGPHRStPESRAAV Presenilin protein stabilization; enzymatic activity, induced 12056836; 20456003 2 1 23 Phosphorylation of site stabilizes the C-terminal fragment of PSEN1.; increases gamma-secretase activity +ARHGEF7 ARHGEF7 GEF; GEF, Rac/Rho; Motility/polarity/chemotaxis Q14155 8874 13q34 human T704-p 455216 EFASRKStAALEEDA RhoGEF67_u2 activity, induced; molecular association, regulation cytoskeletal reorganization RAP1GDS1(DISRUPTS) 16954223 7 6 1 activates ARHGEF7's exchange activity on Rac1 +Gria3 GluR3 Channel, ligand-gated; Membrane protein, integral; Membrane protein, multi-pass Q9Z2W9 53623 X A4|X 23.19 cM mouse Y881-p 461043 YREGYNVyGTESVKI neural plasticity 32071234 2 1 95 +PRKDC DNAPK DNA repair, damage; EC 2.7.11.1; KINASE; Kinase, protein; Nucleolus; Protein kinase, Ser/Thr (non-receptor); Protein kinase, atypical P78527 5591 8q11.21 human S2674-p 3193634 LVDHTSPsSDSLLFA DNAPKcs_CC5 DNA repair, inhibited 24687855 1 2 0 cell survival inhibited +TBXA2R TXA2-R GPCR, family 1; Membrane protein, integral; Membrane protein, multi-pass; Receptor, GPCR P21731 6915 19p13.3 human T337-p 451395 LSLQPQLtQRSGLQ_ receptor desensitization, induced; receptor desensitization, altered signaling pathway regulation 15100160; 17466390 2 3 0 +INVS INVS Q9Y283 27130 9q31.1 human T795-p 1384540900 CAPQKRRtQELRGGR molecular association, regulation SMO(INDUCES) 30598432 1 0 0 +Hif3a HIF3A iso2 Transcription factor; Tumor suppressor Q0VBL6-2 53417 7|7 A2 mouse T12-p 57786401 LQRVRSNtELRKEKS molecular association, regulation; ubiquitination PARK2(INDUCES) 27551449 2 1 0 +TNNI3 TNNI3 Actin-binding; Motility/polarity/chemotaxis; Motor P19429 7137 19q13.42 human S42-p 450690 AKKKSKIsASRKLQL molecular association, regulation; activity, inhibited TNNC1(DISRUPTS) 15134451; 24116014 24 2 0 reduced maximal force generation +ZNF746 PARIS C2H2-type zinc finger protein; Transcription regulation Q6NUN9 155061 7q36.1 human S613-p 25759828 APPDPFKsPASKGPL protein degradation; ubiquitination 28122242 1 2 1 protective effect of DA neuron toxicity +YTHDF2 YTHDF2 RNA processing; RNA-binding Q9Y5A9 51441 1p35.3 human S39-p 483929 DDFEPYLsPQARPNN protein stabilization carcinogenesis, induced; cell growth, induced; apoptosis, inhibited; RNA stability, inhibited 33420027 1 24 12 +KCNMA1 KCNMA1 Channel, potassium; Endoplasmic reticulum; Membrane protein, integral; Membrane protein, multi-pass Q8AYS8 374065 chicken S883-p 4715384 DRSSPDNsPVHGLLR intracellular localization; activity, inhibited 22094329 1 5 0 +CSRP2 CSRP2 Cell development/differentiation Q16527 1466 12q21.2 human Y57-p 470028 AIHDEEIyCKSCYGK LIM intracellular localization transcription, altered 12771930 1 2 1 Nuclear translocation. +SMAD1 SMAD1 DNA-binding; Transcription factor Q15797 4086 4q31.21 human S214-p 451176 PTSSDPGsPFQMPAD molecular association, regulation; intracellular localization YAP1(INDUCES) 19914168; 9335504 3 0 0 Erk-mediated phosphorylation inhibits the nuclear accumulation of Smad1. +CRMP1 CRMP-1 Cell development/differentiation; Cytoskeletal; Hydrolase Q14194 1400 4p16.2 human S522-p 1295503 PAPSAKSsPSKHQPP cytoskeletal reorganization 18003833 4 12 7 Phosphorylation induces increased density of synaptic clusters and neurite projection. +OCLN occludin Cell adhesion; Membrane protein, integral; Membrane protein, multi-pass; Motility/polarity/chemotaxis Q91049 chicken Y379-p 5393504 PELDESQyETDYTTA molecular association, regulation; intracellular localization ZO1(INDUCES) 19017651 1 3 1 +PTPN1 PTP1B EC 3.1.3.48; Motility/polarity/chemotaxis; PHOSPHATASE; Phosphatase; Protein phosphatase, tyrosine (non-receptor) P18031 5770 20q13.13 human S50-p 447811 RNRYRDVsPFDHSRI Y_phosphatase molecular association, regulation; enzymatic activity, inhibited; enzymatic activity, induced signaling pathway regulation INSR(DISRUPTS) 10480872; 11579209; 20615878; 23481236 5 18 17 insulin signaling- glucose metabolism +Mpl MPL Membrane protein, integral; Receptor, cytokine Q08351 17480 4 D2.1|4 54.61 cM mouse S550-p 3091401 SKATVTDsCEEVEPS activity, induced; phosphorylation cell growth, altered 10918061 1 0 0 tyrosine phosphorylation of JAK2 +7a Accessory protein 7a P59635 1489674 SARSCoV1 K120-ub 1883544402 LCFTIKRkTE_____ molecular association, regulation; intracellular localization TAK1(INDUCES); IKKG(INDUCES) 35856559 1 0 0 Accessory protein 7a and | nsp6-pp1a-pp1ab ubiquitiylation are required for the recruitment of NEMO and TAK1 to ORF7a and required for NF-kB activation. +TP53 p53 Activator; DNA-binding; Motility/polarity/chemotaxis; Nuclear receptor co-regulator; Transcription factor; Tumor suppressor P04637 7157 17p13.1 human K132-ub 486294 TYSPALNkMFCQLAK P53 protein degradation; intracellular localization 17371868; 31346036; 31492752 3 2 0 +ARHGAP5 ARHGAP5 GAP; GAP, Rac/Rho; Motility/polarity/chemotaxis Q13017 394 14q12 human Y1109-p 455068 KGYSDEIyVVPDDSQ RhoGAP_pG1_pG2 activity, induced cell motility, altered; cell growth, altered 18829532 2 13 170 inhibits Rho activity, activates Ras activity +GTF2I GTF2I iso2 DNA-binding; Transcription, coactivator/corepressor P78347-2 2969 7q11.23 human Y357-p 448251 QSHVEDLyVEGLPEG GTF2I transcription, altered 11373296 1 1 2 +AKAP8 AKAP8 Adaptor/scaffold; Cell cycle regulation; Mitochondrial; RNA-binding O43823 10270 19p13.12 human Y170-p 15417596 NGSFGGQySECRDPA molecular association, regulation 25770215 1 1 1 Phenylalanine mutants inhibited dissociation from nuclear structures; structural chromatin changes +Kcnj1 ROMK Channel, potassium; Membrane protein, integral; Membrane protein, multi-pass P35560 24521 8q21 rat S219-p 2461201 RVANLRKsLLIGSHI IRK_C activity, induced; protein conformation 18311184 5 0 0 +TP53 p53 Activator; DNA-binding; Motility/polarity/chemotaxis; Nuclear receptor co-regulator; Transcription factor; Tumor suppressor P04637 7157 17p13.1 human K373-ac 458980 SSHLKSKkGQSTSRH protein degradation; molecular association, regulation; protein stabilization; phosphorylation; activity, induced; ubiquitination; intracellular localization; protein conformation cell cycle regulation; carcinogenesis, inhibited; cell growth, inhibited; apoptosis, induced; cell motility, inhibited; transcription, induced; transcription, altered; neural plasticity; autophagy, induced; cell growth, induced; apoptosis, inhibited; transcription, inhibited TAF1(INDUCES); p53(INDUCES); SIRT1(INDUCES); HDAC1(INDUCES); BANP(INDUCES); GTF2H1(INDUCES); p53(DISRUPTS); BCL2L2(INDUCES); FOXM1(INDUCES); p21Cip1(DISRUPTS); p300(INDUCES); SMARCA4(INDUCES); SIN3A(INDUCES); POLA2(INDUCES); FOXA1(INDUCES) DNA(INDUCES) 11094089; 11099047; 11250899; 11971195; 12716906; 14522900; 14759370; 14982997; 15141169; 15520174; 15746940; 16107876; 16291740; 16537920; 16540664; 16717128; 17121856; 17272277; 17403783; 17668048; 17977830; 17996705; 18056437; 18485870; 18523266; 18697203; 19085961; 19265193; 19339993; 19377469; 20075864; 20094059; 21297583; 22249259; 22285752; 22981429; 23148227; 23149944; 23384296; 23576563; 24330748; 25426556; 25521755; 26411366; 27208501; 27423454; 31196136; 31680191; 33097607; 34880421; 36257192; 9288740 95 4 0 After PEPD binding is dissrupted from P53 mutants, K373 acetylation is essential for activation and p53 mutants to refold, reactivates the transcription-dependent tumor suppressor activities of p53 mutants,inhibition of in vivo tumor growth; IKK-alpha and CHK1-dependent p53 phosphorylation and acetylation; promoting the C-terminal acetylation of p53 and may facilitate p53-dependent gene expression ; 20, 164, 305, 320, 370/372/373, 381/382/386 K-R mutants diminsished transactivation, and selective regulation of target genes expression through distinct mechanisms; autophagic degradation of IKKa during the arsenite response +Tnni3 TNNI3 Actin-binding; Motility/polarity/chemotaxis; Motor P23693 29248 1q12 rat T144-p 451483 RGKFKRPtLRRVRIS Troponin activity, inhibited cytoskeletal reorganization 16236710; 18550549; 30844361 29 2 1 increased myofilament Ca2+ sensitivity; regulates cardiac contractile function; acute acceleration of relaxation +SHC4 SHC4 Adaptor/scaffold Q6S5L8 399694 15q21.1 human T159-p 1868546600 GHRATALtPDSCPLP phosphorylation apoptosis, induced; transcription, induced; signaling pathway regulation 31121283 1 1 0 expression and phosphorylation of p21 +NEK6 NEK6 EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, Other; Protein kinase, Ser/Thr (non-receptor) Q9HC98 10783 9q33.3 human T210-p 9258030 AAHSLVGtPYYMSPE Pkinase enzymatic activity, induced cell growth, induced 20595392 1 2 17 +MCM3 MCM3 DNA replication; EC 3.6.4.12 P25205 4172 6p12.2 human K435-ub 12301894 QGRVTIAkAGIHARL MCM cell cycle regulation 27621311 1 6 15 KEAP1-MCM3 associates with chromatin in a cell cycle-dependent manner +Add1 ADD1 Cytoskeletal; Motility/polarity/chemotaxis Q9QYC0 11518 5 B2|5 17.9 cM mouse S465-p 452288 EEGQNGSsPKSKTKW intracellular localization 28982183 0 51 7 abnormal localization on the meiotic spindle +DAP3 DAP3 Apoptosis; Mitochondrial; Nuclear receptor co-regulator P51398 7818 1q22 human S251-p 2226201 LKELKRQsSLGMFHL DAP3 apoptosis, induced 18227431 1 1 0 +CTH CTH Amino Acid Metabolism - cysteine and methionine; Amino Acid Metabolism - glycine, serine and threonine; Cell cycle regulation; EC 4.4.1.1; Energy Metabolism - nitrogen; Lyase; Other Amino Acids Metabolism - selenoamino acid P32929 1491 1p31.1 human S377-p 484505 SDTLIRLsVGLEDEE Cys_Met_Meta_PP enzymatic activity, inhibited Akt1(INDUCES) 25900831; 26539823; 29970364; 31759247 5 4 0 +APOBEC3G APOBEC3G EC 3.5.4.-; Hydrolase; RNA processing; RNA-binding Q9HC16 60489 22q13.1 human K301-ub 11956701 EMAKFISkNKHVSLC NAD2 protein degradation 19887642 1 0 0 +Mdm4 MDM4 EC 6.3.2.-; Ligase; UBIQUITIN LIGASE; Ubiquitin conjugating system; Ubiquitin ligase O35618 17248 1 E4|1 57.75 cM mouse S288-p 456471 DDLEDSRsLSDDTDV molecular association, regulation p53(INDUCES) 29581299 5 0 0 CK1a cooperates with MDMX to inhibit p53 DNA binding +HDAC3 HDAC3 Apoptosis; Cell cycle regulation; DEACETYLASE; Deacetylase; EC 3.5.1.98; Nuclear receptor co-regulator; Transcription, coactivator/corepressor O15379 8841 5q31.3 human S374-p 1874020216 KMLNHAPsVQIHDVP molecular association, regulation; acetylation; enzymatic activity, inhibited transcription, inhibited DAD1(DISRUPTS) 34244427 1 1 0 inhibits deacetylation of p65 +TPX2 TPX2 Cell cycle regulation; Microtubule-binding Q9ULW0 22974 20q11.21 human S738-p 453052 QPLTVPVsPKFSTRF cell cycle regulation 29052541 2 78 7 mitotic delay +Pparg PPAR-gamma iso2 DNA-binding; Nuclear receptor; Transcription factor P37238-2 19016 6 E3|6 53.41 cM mouse K33-sm 7780002 HSHSFDIkPFTTVDF PPARgamma_N activity, inhibited 23826177 2 0 0 +Dcx Doublecortin Cytoskeletal; Motility/polarity/chemotaxis O88809 13193 X|X F2 mouse S297-p 451111 PQKTSAKsPGPMRRS activity, inhibited cell growth, inhibited; cytoskeletal reorganization CDK5(DISRUPTS) 14741103; 17482550; 26526391 8 1 4 S297A constitutively active mutant promotes neuronal survival and axon regeneration. +BAG3 BAG3 Apoptosis; Chaperone O95817 9531 10q26.11 human S187-p 12217052 SSSSSSAsLPSSGRS cell motility, induced 23108398 1 2 0 involved in epithelial-mesenchymal transition (EMT); promotes migration and invasion of FRO cells +RAB4A Rab4 G protein; G protein, monomeric; G protein, monomeric, Rab P20338 5867 1q42.13 human S204-p 451289 AALRQLRsPRRAQAP molecular association, regulation; intracellular localization autophagy, induced LC3A(INDUCES) 1425574; 24404161 2 0 0 phosphorylation-resistant Rab4 S204Q mutation promotes autophagy ; S199 phosphorylation was required for the accumulation of rab4 in the cytosol of mitotic cells. +OCLN occludin Cell adhesion; Membrane protein, integral; Membrane protein, multi-pass; Motility/polarity/chemotaxis Q16625 100506658 5q13.2 human T400-p 471470 TEQDHYEtDYTTGGE molecular association, regulation occludin(DISRUPTS); ZO2(DISRUPTS) 23758859 1 1 5 . Phosphorylation affects occludin solubility and regulates assembly/disassembly of TJ proteins +GLE1 GLE1 Karyopherin; Nuclear export Q53GS7 2733 9q34.11 human T102-p 472369 FSPASPAtPNGTKGK molecular association, regulation GLE1(INDUCES) 30429220 1 13 12 self-association stress granules' assembly and disassembly, DDX3-ATPase activity inhibited +MST1R Ron EC 2.7.10.1; KINASE; Kinase, protein; Membrane protein, integral; Protein kinase, TK; Protein kinase, tyrosine (receptor) Q04912 4486 3p21.31 human S1394-p 450270 VRRPRPLsEPPRPT_ molecular association, regulation 14-3-3 beta(INDUCES) 12919677; 14505491 2 2 22 +Cdc20 CDC20 Cell cycle regulation; Ubiquitin conjugating system Q62623 64515 5q36 rat S51-p 20653800 RAANRSHsAGRTPGR intracellular localization; activity, inhibited cell growth, inhibited 21725312 3 2 3 phosphorylation decreased dendritic length +Itpr1 IP3R1 Channel, calcium; Channel, ligand-gated; Membrane protein, integral; Membrane protein, multi-pass P11881 16438 6 E1|6 49.74 cM mouse S421-p 450268 VMLKIGTsPLKEDKE MIR activity, induced cell growth, induced 26259730; 36001172 4 0 1 +ITPR1 IP3R1 Channel, calcium; Channel, ligand-gated; Membrane protein, integral; Membrane protein, multi-pass Q14643 3708 3p26.1 human Y353-p 450970 NAQEKMVySLVSVPE MIR activity, induced; receptor desensitization, altered transcription, altered Other(NOT_REPORTED) 14761954; 18056410 4 0 0 +TP63 p63 iso2 DNA-binding; Transcription factor Q9H3D4-2 8626 3q28 human S301-p 451602 TSIKKRRsPDDELLY P53_tetramer protein degradation 30301786 2 4 0 +Kcnj8 KCNJ8 Channel, potassium; Membrane protein, integral; Membrane protein, multi-pass Q63664 25472 4q44 rat S354-p 1458600 RVAAPRCsARELDEK IRK_C activity, inhibited 18048350 1 0 0 +Slc1a2 GLT1 Membrane protein, integral; Membrane protein, multi-pass; Transporter; Transporter, SLC family P31596 29482 3q32 rat K570-ub 3884559 SVEEEPWkREK____ receptor internalization, induced; protein degradation 18805448 1 1 8 +ATM ATM DNA repair, damage; EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, Ser/Thr (non-receptor); Protein kinase, atypical; Tumor suppressor Q13315 472 11q22.3 human S85-p 481858 AKPNVSAsTQASRQK TAN molecular association, regulation; enzymatic activity, inhibited; protein conformation cell cycle regulation; apoptosis, inhibited MRE11A(DISRUPTS); NBS1(DISRUPTS) 27939942 1 4 0 +REST REST C2H2-type zinc finger protein; Cell development/differentiation; DNA-binding; Transcription factor Q13127 5978 4q12 human S1024-p 138107501 SDLSDNMsEGSDDSG protein degradation; ubiquitination 29156689 1 0 0 +Ngef ephexin-1 iso2 GEF; GEF, Rac/Rho Q8CHT1-2 53972 1 D|1 44.42 cM mouse Y87-p 455579 IEQIGLLyQEYRDKS cytoskeletal reorganization 20152127 4 0 2 disperse of AChR clusters +GTF2A1 GTF2A1 Transcription, coactivator/corepressor P52655 2957 14q31.1 human S280-p 449822 VDGTGDTsSEEDEDE TFIIA transcription, induced 11278496 1 0 0 +MRE11 MRE11A Cell cycle regulation; DNA repair, damage; DNA-binding; Deoxyribonuclease P49959 4361 11q21 human K480-ub 573764936 LVKYQLEkTQRFLKE activity, induced; ubiquitination DNA repair, induced 36563124 1 3 0 MRE11A promotes its exonuclease activity +NR1D1 NR1D1 Nuclear receptor; Transcription factor P20393 9572 17q21.1 human S59-p 471092 FPPSPTGsLTQDPAR protein stabilization 16484495 1 0 0 +ACSL4 ACSL4 EC 6.2.1.3; Ligase; Lipid Metabolism - fatty acid; Membrane protein, integral O60488 2182 Xq23 human S447-p 23079030 LSGGAPLsPQTHRFM AMP-binding protein degradation 37428466 1 5 2 inhibition of ACSL4-driven lipid peroxidation and ferroptosis is necessary for CDK1 to promote oxaliplatin resistance in CRC +SERINC3 SERINC3 Cell surface; Membrane protein, integral; Membrane protein, multi-pass Q13530 10955 20q13.12 human S383-p 1255792400 DTTTSGAsDEEDGQP Serinc molecular association, regulation AP1M1(INDUCES); AP2M1(INDUCES) 30135209 1 1 0 Mu subunits of AP-1 and AP-2 fused to MBP +SQSTM1 SQSTM1 Autophagy; Nuclear receptor co-regulator; Ubiquitin conjugating system Q13501 8878 5q35.3 human S366-p 476290 PESEGPSsLDPSQEG protein stabilization carcinogenesis, induced 31810986 2 25 5 +Cttn Cortactin Actin-binding; Cytoskeletal; Motility/polarity/chemotaxis NP_001385572 60465 1q41-q42 rat Y482-p 447704 YQAEDDTyDGYESDL cell adhesion, altered 15383621 25 1 3 +DRD2 DRD2 GPCR, family 1; Membrane protein, integral; Membrane protein, multi-pass; Receptor, GPCR P14416 1813 11q23.2 human K251-ub 1877221608 CTHPEDMkLCTVIMK 7tm_1 protein degradation 32572597 1 0 0 +Hsf1 HSF1 DNA-binding; Transcription factor F1MAF1 79245 7q34 rat K80-ac 6741100 LNMYGFRkVVHIEQG HSF_DNA-bind molecular association, regulation apoptosis, induced; transcription, inhibited DNA(DISRUPTS) 28547133 5 2 0 +KHDRBS1 KHDRBS1 RNA-binding Q07666 10657 1p35.2 human K96-sm 3755607 PSATASVkMEPENKY apoptosis, inhibited; transcription, inhibited 16568089 1 0 0 +HSPB1 HSP27 Chaperone; Heat shock protein; Motility/polarity/chemotaxis; SUMO LIGASE; SUMO ligase P04792 3315 7q11.23 human S82-p 448403 RALSRQLsSGVSEIR protein degradation; molecular association, regulation; phosphorylation; activity, induced; sumoylation; ubiquitination; intracellular localization; protein conformation carcinogenesis, induced; apoptosis, altered; cell motility, induced; signaling pathway regulation; transcription, altered; autophagy, induced; cell differentiation, induced; cell growth, induced; apoptosis, inhibited; cytoskeletal reorganization; transcription, inhibited; cell growth, altered TRAF6(DISRUPTS); TPM1(INDUCES); p53(INDUCES); HSF1(DISRUPTS); hnRNP D0(DISRUPTS); HSP27(DISRUPTS); Akt1(DISRUPTS) RNA(DISRUPTS) 11383510; 11912188; 12367505; 12740362; 14749215; 15581903; 18477563; 18950704; 19597476; 21245386; 21989268; 32570757; 34477462; 34498800; 34516752; 34851698; 35000271; 35499078; 36260112; 36701233 78 104 289 induces lysophagy +HDAC1 HDAC1 DEACETYLASE; Deacetylase; EC 3.5.1.98; Hydrolase; Nuclear receptor co-regulator Q13547 3065 1p35.2-p35.1 human K476-sm 2407422 KPEAKGVkEEVKLA_ cell cycle regulation; transcription, inhibited 11960997 3 3 0 +Creb1 CREB iso1 DNA-binding; Transcription factor P15337-1 81646 9q32 rat S142-p 448547 RKILNDLsSDAPGVP pKID molecular association, regulation; activity, inhibited transcription, inhibited CBP(DISRUPTS); CREB iso1(DISRUPTS) 11013247; 11970864; 9668047 11 20 2 +PPP1R12A MYPT1 Motility/polarity/chemotaxis; PHOSPHATASE; Protein phosphatase, regulatory subunit O14974 4659 12q21.2-q21.31 human T696-p 448587 ARQSRRStQGVTLTD enzymatic activity, inhibited; intracellular localization; phosphorylation cell motility, induced; cell growth, inhibited; cell differentiation, induced; cell adhesion, induced; cytoskeletal reorganization; signaling pathway regulation 16038801; 31834925; 33762326; 33802280; 35594862 66 42 226 +IL6ST gp130 Membrane protein, integral; Receptor, cytokine P40189 3572 5q11.2 human Y905-p 448182 DEGMPKSyLPQTVRQ cell cycle regulation; transcription, altered 10623831 3 4 16 +Egfr EGFR EC 2.7.10.1; KINASE; Kinase, protein; Membrane protein, integral; Oncoprotein; Protein kinase, TK; Protein kinase, tyrosine (receptor) Q01279 13649 11 A2|11 9.41 cM mouse S1070-p 448051 DAFLQRYsSDPTGAV carcinogenesis, induced 36624189 17 6 7 +SLC3A2 SLC3A2 Membrane protein, integral; Transporter P08195 6520 11q12.3 human S410-p 6003502 SYLSDSGsTGEHTKS cell adhesion, altered 19065266 1 0 0 enhances cell- cell interactions +H3C1 H3 DNA-binding P68431 8350 6p22.2 human K36-m2 1458610 APATGGVkKPHRYRP Histone molecular association, regulation; acetylation cell cycle regulation; carcinogenesis, induced; carcinogenesis, inhibited; cell differentiation, induced; chromatin organization, altered; transcription, induced; transcription, inhibited NBS1(INDUCES) 16732292; 17589499; 18923077; 20139424; 20417597; 20457893; 25823024; 32826945 44 18 7 decreases histone H3/H4 acetylation; hemin-mediated differentiation +RIGI RIGI EC 3.6.4.13; Hydrolase O95786 23586 9p21.1 human K96-sm 63243403 IESWDFKkIEKLEEY phosphorylation 28250012 1 0 0 dephosphorylation +KLF13 KLF13 C2H2-type zinc finger protein; DNA-binding Q9Y2Y9 51621 15q13.3 human K168-ac 460599 ESPQRKHkCHYAGCE zf-C2H2 molecular association, regulation DNA(DISRUPTS) 12758070 1 0 0 +SREBF1 SREBP-1 DNA-binding; Membrane protein, integral; Membrane protein, multi-pass; Transcription factor P36956 6720 17p11.2 human S338-p 458357 IEKRYRSsINDKIIE HLH molecular association, regulation transcription, inhibited SREBP-1(DISRUPTS) 16381800 4 1 0 inhibits lipogenesis +H3c1 H3 DNA-binding P68433 360198 13|13 A3.1 mouse K14-ac 458954 ARKSTGGkAPRKQLA Histone molecular association, regulation cell cycle regulation; endocytosis, altered; cell differentiation, induced; chromatin organization, altered; cell adhesion, altered; transcription, induced; transcription, altered DNA(INDUCES) 10899125; 17590163; 17823087; 18662547; 19109180; 19264835; 19707598; 19859561; 20129940; 20543957; 20574709; 20710121; 23341587; 33195484 162 31 355 modulates circadian rhythms; may be associated with gene expression; axon guidance +MRPL10 MRPL10 Mitochondrial; Ribosomal; Translation Q3MHY7 515014 cow K196-ac 12674404 QGFINYSkLPSLALA translation, induced 20042612 1 1 0 downregulates protein synthesis +Pak3 PAK3 EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, STE; Protein kinase, Ser/Thr (non-receptor) Q62829 29433 Xq33 rat T421-p 448126 PEQSKRStMVGTPYW Pkinase enzymatic activity, induced 11278486 3 2 11 +BLM BLM DNA repair, damage; DNA replication; EC 3.6.4.12; Helicase P54132 641 15q26.1 human T171-p 471430 ETSKSFVtPPQSHFV BLM_N protein degradation; molecular association, regulation; ubiquitination FBXW7(INDUCES) 26028025 1 8 8 +Nalcn VGCNL1 Channel, calcium; Membrane protein, integral; Membrane protein, multi-pass; Transporter, ion channel Q6Q760 266760 15q25 rat S1653-p 1869465802 TLSDRGGsRQDAADT activity, inhibited 31601786 1 0 0 VGCNL1 channel activity inhibited +TP53 p53 Activator; DNA-binding; Motility/polarity/chemotaxis; Nuclear receptor co-regulator; Transcription factor; Tumor suppressor P04637 7157 17p13.1 human K372-ne 12067100 HSSHLKSkKGQSTSR transcription, inhibited 15242646 1 0 0 +CHD4 CHD-4 DNA-binding; EC 3.6.4.12; Helicase Q14839 1108 12p13.31 human S428-p 470519 WEAKEDNsEGEEILE molecular association, regulation chromatin organization, altered; transcription, induced DNA(DISRUPTS); RNA(DISRUPTS) 29907651 1 44 0 +ARHGEF1 ARHGEF1 GEF; GEF, Rac/Rho; Motility/polarity/chemotaxis Q92888 9138 19q13.2 human Y738-p 13421400 WDQEAQIyELVAQTV PH_16 activity, induced 20098430 1 0 0 +KEAP1 KEAP1 Endoplasmic reticulum; Motility/polarity/chemotaxis; Transcription regulation; UBIQUITIN LIGASE; Ubiquitin conjugating system Q14145 9817 19p13.2 human S53-p 1410340102 QHGNRTFsYTLEDHT molecular association, regulation transcription, induced NRF2(DISRUPTS) 30576774 1 1 0 free NRF2 nuclear localization, NQO1, GCLC transcription induced +FCRL3 FCRL3 Adaptor/scaffold; Membrane protein, integral Q96P31 115352 1q23.1 human Y650-p 469980 PMELEPMySNVNPGD molecular association, regulation ZAP70(INDUCES) 12051764 1 0 0 +SLC25A4 SLC25A4 Membrane protein, integral; Membrane protein, multi-pass; Mitochondrial; Transporter; Transporter, SLC family P12235 291 4q35.1 human Y195-p 457913 RAAYFGVyDTAKGML Mito_carr; TM cell growth, altered 20007455 1 10 242 required for an efficient oxidative growth in yeast +RAB37 RAB37 G protein; G protein, monomeric; G protein, monomeric, Rab Q96AX2 326624 17q25.1 human T172-p 556476901 YGVPFLEtSAKTGMN Ras intracellular localization; activity, inhibited exocytosis, inhibited; cell motility, induced 29312551 1 0 0 eliminates TIMP1 secretion, promotes metastasis +ULK1 ULK1 Autophagy; EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, Other; Protein kinase, Ser/Thr (non-receptor) O75385 8408 12q24.33 human K607-ac 27850503 RNLRGSPkLPDFLQR enzymatic activity, induced apoptosis, induced 22539723 2 1 0 serum deprivation induced autophagy +DDAH2 DDAH2 Apoptosis; EC 3.5.3.18; Hydrolase O95865 23564 6p21.33 human T211-p 1872776104 DHPYASLtLPDDAAA intracellular localization; phosphorylation; enzymatic activity, induced signaling pathway regulation 33850055 1 1 0 regulates RLR signaling, regulates DRP1 anf IRF3 phosphorylation +PAK1 PAK1 EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, STE; Protein kinase, Ser/Thr (non-receptor) Q13153 5058 11q13.5-q14.1 human S223-p 454121 DVATSPIsPTENNTT activity, induced; intracellular localization; enzymatic activity, induced carcinogenesis, induced; cell motility, induced 23885116; 26160174 3 25 14 membrane localization; malignant transformation prostate +KCNA5 Kv1.5 Channel, potassium; Membrane protein, integral; Membrane protein, multi-pass P22460 3741 12p13.32 human K536-sm 3144801 HEEPAVLkEEQGTQS activity, induced 17261810 1 0 0 +AKAP5 AKAP5 Adaptor/scaffold P24588 9495 14q23.3 human S92-p 31878521 LVTRRKRsESSKQQK WSK molecular association, regulation ACTB(INDUCES) 29196604 1 1 0 AKAP5 de-palmitoylation, AKAP5 from dendritic spines +NOTCH1 Notch 1 Membrane protein, integral; Motility/polarity/chemotaxis; Oncoprotein; Receptor, misc.; Transcription factor P46531 4851 9q34.3 human S1791-p 27457604 REPLGEDsVGLKPLK protein degradation cell cycle regulation 31597699 1 2 0 promotes inflammatory cytokines secretion +Bcl2 Bcl-2 Apoptosis; Autophagy; Membrane protein, integral; Oncoprotein P49950 24224 13p11 rat S70-p 448395 RDTAARTsPLRPLVA apoptosis, altered 14572466; 15994315 49 1 0 +PTH1R PTHR GPCR, family 2; Membrane protein, integral; Membrane protein, multi-pass; Receptor, GPCR Q03431 5745 3p21.31 human S493-p 2853105 KARSGSSsYSYGPMV receptor internalization, induced; molecular association, regulation ARR3(INDUCES) 27623777 4 2 0 S503 AND T504 IN THE SECOND CLUSTER ARE RESPONSIBLE FOR 70% OF ARRESTIN3 RECRUITMENT +Cdc25a CDC25A EC 3.1.3.48; Motility/polarity/chemotaxis; PHOSPHATASE; Protein phosphatase, dual-specificity P48964 12530 9 F2|9 59.81 cM mouse S75-p 449340 SSLQRMGsSESTDSG protein degradation cell cycle regulation; apoptosis, altered 15928203 12 1 1 +PER2 PER2 Nuclear receptor co-regulator; Nucleolus; Transcription factor O15055 8864 2q37.3 human S662-p 449331 ALPGKAEsVASLTSQ protein degradation; protein stabilization; intracellular localization; phosphorylation transcription, induced 17218255; 21324900; 30425162 8 1 1 Phosphorylation of S662 promotes casein kinase I to phosphorylate nearby residues. CKI does not appear to phosphorlyate this residue (requires priming kinase). Phosphorylation increased period length (tau). Nonphosphorylated protein is mainly nuclear (as opposed to nuclear and cytoplasmic). Phosphorylated Per2 promotes its own transcription. +BARD1 BARD1 EC 6.3.2.-; EC 6.3.2.19; Ligase; UBIQUITIN LIGASE; Ubiquitin conjugating system; Ubiquitin ligase Q99728 580 2q35 human S251-p 455769 SQPSVISsPQINGEI cell cycle regulation 15855157 2 1 1 resistance to genotoxic stress (mitomycin C) +EIF4EBP1 4E-BP1 Translation; Translation initiation Q13541 1978 8p11.23 human S65-p 447527 FLMECRNsPVTKTPP eIF_4EBP molecular association, regulation; protein conformation; activity, inhibited; phosphorylation translation, altered; cell growth, induced; apoptosis, inhibited; translation, induced; translation, inhibited mTOR(DISRUPTS); EIF4E(DISRUPTS) 11553333; 15051500; 20880835; 21734039; 21914810; 22071574; 24247720; 25702871; 27065332; 34546793; 35626002 104 60 6 +RANBP9 RANBP9 Adaptor/scaffold; GAP; GAP, Ras; Nuclear receptor co-regulator Q96S59 10048 6p23 human S603-p 482142 TEMEVDSsQLRRQLC CTLH intracellular localization 26943034 1 1 0 nuclear accumulation +GAPDH GAPDH Carbohydrate Metabolism - glycolysis and gluconeogenesis; EC 1.2.1.12; Oxidoreductase P04406 2597 12p13.31 human Y42-p 450511 DPFIDLNyMVYMFQY Gp_dh_N intracellular localization DNA repair, induced; apoptosis, inhibited PKCI(INDUCES) 17488287; 32539222 2 1 4 +LATS1 LATS1 EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, AGC; Protein kinase, Ser/Thr (non-receptor); Tumor suppressor O95835 9113 6q25.1 human K830-sm 62518204 GFIHRDIkPDNILID Pkinase enzymatic activity, induced transcription, induced 27847303 1 0 0 +SOD1 SOD1 Apoptosis; EC 1.15.1.1; Mitochondrial; Nuclear receptor co-regulator; Oxidoreductase P00441 6647 21q22.11 human T40-p 1100571300 WGSIKGLtEGLHGFH Sod_Cu enzymatic activity, inhibited cell growth, inhibited 29727620; 35452786 2 0 0 modulate cellular ROS and maintain cancer survival in an ischemic environment; ischemia-induced cell death +CDC27 CDC27 Cell cycle regulation P30260 996 17q21.32 human S154-p 18258506 FLWSPFEsLCEIGEK cell growth, altered 21209074 1 0 0 regulates SnoN degradation +BEST1 BEST1 Channel, chloride; Membrane protein, integral; Membrane protein, multi-pass; Transporter; Transporter, ion channel O76090 7439 11q12.3 human S358-p 9720901 SAQFRRAsFMGSTFN activity, induced; molecular association, regulation; intracellular localization 14-3-3 gamma(INDUCES) 19635817; 29121962 2 0 0 glutamate release from hippocampal astrocyte; S358E mutation prevents channel rundown ; whole-cell current and surface expression of Best1 channel in astrocytes +PTEN PTEN Carbohydrate Metabolism - inositol phosphate; EC 3.1.3.16; EC 3.1.3.48; EC 3.1.3.67; Motility/polarity/chemotaxis; Nuclear receptor co-regulator; PHOSPHATASE; Phosphatase, lipid; Tumor suppressor P60484 5728 10q23.31 human K254-sm 28722900 LPVCGDIkVEFFHKQ PTEN_C2 protein stabilization; ubiquitination; intracellular localization cell cycle regulation; carcinogenesis, inhibited; apoptosis, induced; cell growth, inhibited 23888040; 24344134; 27506944; 27852060 4 1 0 +TPX2 TPX2 Cell cycle regulation; Microtubule-binding Q9ULW0 22974 20q11.21 human T320-p 626439300 KKRTFDEtVSTYVPL intracellular localization KPNB1(INDUCES) 29276125 1 1 0 accumulation of TPX2 at the prophase centrosome +MDM2 MDM2 EC 6.3.2.-; EC 6.3.2.19; Inhibitor; Ligase; NEDDYLATION LIGASE; Neddylation Ligase; Nucleolus; Oncoprotein; UBIQUITIN LIGASE; Ubiquitin conjugating system; Ubiquitin ligase Q00987 4193 12q15 human K182-ac 35480408 LSGERQRkRHKSDSI protein stabilization; molecular association, regulation; ubiquitination; intracellular localization; protein conformation apoptosis, inhibited; transcription, inhibited KPNA1(DISRUPTS); USP7(INDUCES) 28196907 1 0 0 decreases MDM2 self-ubiquitination, increases MDM2-ubiquitination activity toward p53 +SPAG5 SPAG5 Cell cycle regulation Q96R06 10615 17q11.2 human S135-p 460403 KTIVLVPsPLGQQQD intracellular localization cell cycle regulation 27325694 1 16 0 localization and formation of kinetochores +Carm1 CARM1 EC 2.1.1.125; METHYLTRANSFERASE; Methyltransferase; Methyltransferase, protein arginine; Nuclear receptor co-regulator Q9WVG6 59035 9|9 A3 mouse S229-p 486445 HAEVLVKsNNLTDRI PrmA molecular association, regulation; enzymatic activity, inhibited transcription, inhibited CARM1(DISRUPTS) 17640894 1 0 0 +GLI1 GLI1 C2H2-type zinc finger protein; Oncoprotein; Transcription factor P08151 2735 12q13.3 human T304-p 27708600 GEKPHKCtFEGCRKS cell growth, induced; transcription, induced DNA(INDUCES) 23446420 1 0 0 +Snca SNCA Adaptor/scaffold O55042 20617 6 B3|6 29.15 cM mouse S129-p 448278 SEAYEMPsEEGYQDY Synuclein receptor internalization, induced; protein stabilization; molecular association, regulation; intracellular localization endocytosis, induced; transcription, induced; transcription, altered ubiquitin(INDUCES); LAG3(INDUCES); APLP1(INDUCES) 17360705; 32024799; 33549656; 34092244; 34172566; 34326260; 35250825; 36966145; 37626586 143 7 0 induce neurodegeneration, promotes cell to cell transmission; regulates Nrf2 localization +Tpt1 TPT1 Calcium-binding; Microtubule-binding P63028 22070 14 D3|14 40.29 cM mouse S64-p 3146607 PEGEGTEsTVVTGVD TCTP cell cycle regulation; apoptosis, inhibited; cytoskeletal reorganization 12167714 4 1 0 +Fgd1 FGD1 GEF; GEF, misc. P52734 14163 X F3|X 68.46 cM mouse S205-p 3193805 LVPRAEAsTSSAAVS intracellular localization cytoskeletal reorganization 20045932 2 2 0 +Pak1 PAK1 EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, STE; Protein kinase, Ser/Thr (non-receptor) O88643 18479 7 E1|7 53.57 cM mouse S21-p 448174 APPMRNTsTMIGAGS activity, induced; molecular association, regulation; intracellular localization NCK1(DISRUPTS) 14585966 3 0 10 +Stat5b STAT5B DNA-binding; Oncoprotein; Transcription factor P42232 20851 11 D|11 63.63 cM mouse S730-p 448751 TYMDQAPsPVVCPQA activity, induced 12091337 14 0 0 +SHC4 SHC4 Adaptor/scaffold Q6S5L8 399694 15q21.1 human Y424-p 462715 NSKCSSVyENCLEQS molecular association, regulation GRB2(INDUCES); SHP-2(INDUCES) 17452444; 28213521 2 5 40 +DROSHA DROSHA EC 3.1.26.3; Nucleolus; RNA processing; RNA-binding; Ribonuclease Q9NRR4 29102 5p13.3 human S255-p 40274400 DRRERGRsPDRRRQD molecular association, regulation DGCR8(DISRUPTS) 25699712 1 1 0 +CD274 PD-L1 Membrane protein, integral Q9NZQ7 29126 9p24.1 human T194-p 1874101908 EEKLFNVtSTLRINT C2-set_2 O-GlcNAc glycosylation; protein stabilization; ubiquitination carcinogenesis, induced 34315872 1 0 0 inhibits ubiquitination +Egfr EGFR EC 2.7.10.1; KINASE; Kinase, protein; Membrane protein, integral; Oncoprotein; Protein kinase, TK; Protein kinase, tyrosine (receptor) Q01279 13649 11 A2|11 9.41 cM mouse Y1172-p 448059 MSLDNPDyQQDFFPK enzymatic activity, induced 16902180 44 60 967 +TTK TTK Cancer Testis Antigen (CTA); EC 2.7.12.1; KINASE; Kinase, protein; Protein kinase, Other; Protein kinase, dual-specificity (non-receptor) P33981 7272 6q14.1 human S362-p 13194902 TLKNKTEsSLLAKLE intracellular localization; enzymatic activity, induced 26119734 2 2 0 regulates spindle assembly checkpoint and recruitment of SAC proteins +NET1 NET1 GEF; GEF, Rac/Rho; Motility/polarity/chemotaxis; Oncoprotein Q7Z628 10276 10p15.1 human S100-p 3204288 RPLARVTsLANLISP protein stabilization 26456332 1 9 0 inhibits extracellular matrix degradation +Scn2a SCN2A Channel, sodium; Membrane protein, integral; Membrane protein, multi-pass P04775 24766 3q21 rat Y66-p 1046203 GKSLPFIyGDIPPEM molecular association, regulation; activity, inhibited Fyn(INDUCES) 17959797 1 0 0 +KCNIP3 calsenilin Calcium-binding; Transcription factor Q9Y2W7 30818 2q11.1 human S63-p 450214 APQGSDSsDSELELS protein processing 12837631 1 0 0 Phosphorylation of calsenilin at Ser-63 inhibits cleavage of the molecule by caspase-3. +TP73 p73 DNA-binding; Transcription factor; Tumor suppressor O15350 7161 1p36.32 human S48-p 52434701 VVGGTDSsMDVFHLE intracellular localization; activity, inhibited cell cycle regulation; apoptosis, induced; cell motility, induced; cell growth, induced; apoptosis, inhibited; transcription, inhibited 26625870; 26640387 2 1 0 +RB1 Rb Nuclear receptor co-regulator; Oncoprotein; Transcription, coactivator/corepressor; Tumor suppressor P06400 5925 13q14.2 human S758-p 1878197600 SIIVFYNsVFMQRLK molecular association, regulation; protein conformation carcinogenesis, induced; cell growth, induced; apoptosis, inhibited; transcription, inhibited NFkB-p65(DISRUPTS) 35950917 1 0 0 +Dtna DTNA Motility/polarity/chemotaxis Q9D2N4 13527 18 A2|18 12.08 cM mouse Y713-p 1869344404 TQPEDGNyENESVRQ protein stabilization; molecular association, regulation KAP(INDUCES) 32532815 1 0 0 +Slc5a5 SLC5A5 Membrane protein, integral; Membrane protein, multi-pass; Transporter; Transporter, SLC family Q63008 114613 16p14 rat S581-p 990309 DTATLEEsLVKGPED activity, induced 17913707 1 1 0 +RUVBL2 RUVBL2 EC 3.6.4.12; Helicase Q9Y230 10856 19q13.33 human K456-sm 12004420 AFLFNELkGETMDTS molecular association, regulation; intracellular localization chromatin organization, altered; transcription, inhibited HDAC1(INDUCES) 16699503 1 2 0 UBC9 levels were increased and SENP1 and SENP6 were decreased in metastatic cells. +Cacng2 Stargazin Channel, calcium; Membrane protein, integral; Membrane protein, multi-pass O88602 12300 15 E1|15 36.92 cM mouse S247-p 455319 SSRSTEPsHSRDASP activity, induced; intracellular localization 15664178; 20670832 3 0 0 AMPAR immobilization in synaptic membrane; enhances AMPA receptor responses and is required for long-term potentiation +CYP3A4 CYP3A4 Cell surface; Cofactor and Vitamin Metabolism - retinol; EC 1.14.14.1; Lipid Metabolism - linoleic acid; Membrane protein, integral; Oxidoreductase; Xenobiotic Metabolism - drug metabolism - cytochrome P450; Xenobiotic Metabolism - drug metabolism - other enzymes; Xenobiotic Metabolism - metabolism by cytochrome P450 P08684 1576 7q22.1 human S478-p 5938006 TQIPLKLsLGGLLQP p450 protein degradation; ubiquitination 19095658; 22101235; 25451919 3 2 0 +Ptk2 FAK EC 2.7.10.2; KINASE; Kinase, protein; Protein kinase, TK; Protein kinase, tyrosine (non-receptor) P34152 14083 15 D3|15 33.94 cM mouse Y397-p 447887 SVSETDDyAEIIDEE activity, induced; protein degradation; molecular association, regulation; intracellular localization; enzymatic activity, induced; phosphorylation cell cycle regulation; carcinogenesis, induced; cell motility, induced; cell adhesion, induced; cell adhesion, inhibited; signaling pathway regulation; cell growth, induced; cell motility, altered; cell growth, altered; transcription, induced; transcription, altered; neural plasticity; cell differentiation, induced; apoptosis, inhibited; cytoskeletal reorganization; cell adhesion, altered GRB2(INDUCES); P130Cas(INDUCES); Src(INDUCES); Src iso1(INDUCES); Arp3(DISRUPTS); SOCS3(INDUCES); SOCS1(INDUCES); PXN(INDUCES); SHC1(INDUCES) 10672902; 14517242; 16818654; 17721515; 19776009; 28348210; 32181337; 33730293; 33883558; 34475109; 34654724; 35525274; 35536885; 35538070; 36209205; 36438565; 36870331; 36997926; 37245640; 8816475; 9148935 371 31 474 +Glud1 GLUD1 Amino Acid Metabolism - alanine, aspartate and glutamate; Amino Acid Metabolism - arginine and proline; EC 1.4.1.3; Energy Metabolism - nitrogen; Mitochondrial; Other Amino Acids Metabolism - D-Glutamine and D-glutamate; Oxidoreductase P26443 14661 14 B|14 20.8 cM mouse Y135-p 3552510 SWEVIEGyRAQHSQH ELFV_dehydrog_N enzymatic activity, induced carcinogenesis, induced 36516759 1 3 50 +NGFR NGFR Membrane protein, integral; Receptor, misc. P18519 chicken S266-p 9993601 IAFKRWNsCKQNKQG TNFR_16_TM protein stabilization 19710323 1 1 0 +BNIP3 BNIP3 Membrane protein, integral; Mitochondrial Q12983 664 10q26.3 human T188-p 41388500 IYIGRRLtTSTSTF_ BNIP3 molecular association, regulation OPA1(DISRUPTS) 26102349 2 2 0 prevents mitochondrial damage, prevents cell death +SKAP2 SKAP2 Adaptor/scaffold O75563 8935 7p15.2 human Y75-p 449669 DAEDGEEyDDPFAGP protein conformation 21719704 2 4 3 +EPRS1 EPRS Aminoacyl-tRNA synthetase; Cofactor and Vitamin Metabolism - porphyrin and chlorophyll; EC 6.1.1.15; EC 6.1.1.17; Ligase; Translation; Translation regulation P07814 2058 1q41 human S886-p 452230 LSQSSDSsPTRNSEP molecular association, regulation; phosphorylation translation, altered; translation, inhibited NSAP1(INDUCES); GAPDH(INDUCES); RPL13A(INDUCES); NSAP1(DISRUPTS) 19647514; 21220307; 23071094 6 52 6 +Eif2ak1 HRI EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, Other; Protein kinase, Ser/Thr (non-receptor); Translation Q9Z2R9 15467 5|5 G2 mouse T490-p 447596 THTSRVGtCLYASPE Pkinase phosphorylation 12767237 1 0 0 +H3C1 H3 DNA-binding P68431 8350 6p22.2 human K9-m1 1458609 RTKQTARkSTGGKAP Histone molecular association, regulation; intracellular localization cell cycle regulation; cell differentiation, induced; chromatin organization, altered; transcription, induced; transcription, inhibited CHD-4(INDUCES) DNA(INDUCES) 16079795; 16732292; 18835819; 19021773; 19022177; 19624289; 19889207; 20548336; 20622854 34 19 14 +ITGB7 ITGB7 Cell adhesion; Membrane protein, integral; Motility/polarity/chemotaxis; Receptor, misc. P26010 3695 12q13.13 human Y758-p 469602 EIYDRREySRFEKEQ Integrin_b_cyt cell adhesion, altered 16874740 1 0 0 +POLB POLB DNA repair, damage; DNA replication; EC 2.7.7.7; Lyase; Transferase P06746 5423 8p11.21 human R83-m1 2363900 FLATGKLrKLEKIRQ DNA repair, induced 16600869 1 0 0 +CTBP1 CTBP1 Cell cycle regulation; EC 1.1.1.-; Nuclear receptor co-regulator; Oxidoreductase; Transcription, coactivator/corepressor Q13363 1487 4p16.3 human T144-p 2089802 LNLYRRAtWLHQALR 2-Hacid_dh; 2-Hacid_dh_C molecular association, regulation; protein conformation transcription, induced CTBP2(INDUCES); GCN5(DISRUPTS) 18184656 1 0 0 +Mastl MASTL EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, AGC; Protein kinase, Ser/Thr (non-receptor) Q8C0P0 67121 2|2 A3 mouse T193-p 3209097 NMMDILTtPSMSKPK Pkinase intracellular localization 24101512 2 3 0 export to the cytoplasm +AURKC AurC iso2 EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, Other; Protein kinase, Ser/Thr (non-receptor) Q9UQB9-2 6795 19q13.43 human T164-p 455456 TPSLRRKtMCGTLDY Pkinase enzymatic activity, induced 15670791 7 11 83 T164A mutant showed decreased kinase activity in vitro. +H2BC3 H2B DNA-binding P33778 3018 6p22.2 human K34-ub 10343623 KKRKRSRkESYSIYV Histone protein conformation chromatin organization, altered 35739357; 36112542 3 8 1 H2BK34ub induces a similar orientation and interaction pattern of Dot1L as H2BK120ub, direct interaction with Dot1L occurs with H2BK120ub; H2BK34ub induces DNA and histone distortion around the modified site.; widens the DNA gyre gap in the nucleosome, facilitates dinucleosome formation, stabilizes dinucleosome stacks; H2BK120-ub does not alter any of these properties +SNCA SNCA Adaptor/scaffold P37840 6622 4q22.1 human K102-sm 3829801 VKKDQLGkNEEGAPQ Synuclein ubiquitination apoptosis, inhibited 21746851; 29180403 5 1 0 +Rela NFkB-p65 DNA-binding; Nuclear receptor co-regulator; Transcription factor Q04207 19697 19 A|19 4.34 cM mouse K310-ac 459096 KRTYETFkSIMKKSP activity, induced; molecular association, regulation; intracellular localization cell differentiation, inhibited; transcription, induced; transcription, altered; signaling pathway regulation; chromatin organization, altered; cell differentiation, induced; apoptosis, inhibited; transcription, inhibited DNA(INDUCES); DNA(DISRUPTS) 17590163; 19103747; 19965984; 21900162; 23172686; 23555753; 23597856; 24013120; 24211200; 26226624; 26279947; 26799284; 26836609; 27507649; 30716535; 30736313; 33215396 84 5 0 +BCL10 Bcl-10 Apoptosis; Transcription, coactivator/corepressor; Tumor suppressor O95999 8915 1p22.3 human S218-p 469572 EEGTCANsSEMFLPL molecular association, regulation; intracellular localization Bcl-3(INDUCES) 16280327 3 0 0 +PAK6 PAK6 EC 2.7.11.1; KINASE; Kinase, protein; Nuclear receptor co-regulator; Protein kinase, STE; Protein kinase, Ser/Thr (non-receptor) Q9NQU5 56924 15q15.1 human S360-p 12099459 RTWHAQIsTSNLYLP molecular association, regulation; enzymatic activity, induced carcinogenesis, induced; cell motility, induced AR(INDUCES) 24130878 1 1 0 promotion of cell motility and invasion +SUCLA2 SCS-beta Carbohydrate Metabolism - citrate (TCA) cycle; Carbohydrate Metabolism - propanoate; EC 6.2.1.5; Ligase; Mitochondrial Q9P2R7 8803 13q14.2 human S79-p 27457818 PKGYVAKsPDEAYAI ATP-grasp_2 molecular association, regulation apoptosis, induced glutaminase(DISRUPTS) 33991485 1 6 0 +ESR1 ER-alpha DNA-binding; Nuclear receptor; Transcription factor P03372 2099 6q25.1-q25.2 human K302-ub 2134725 PLMIKRSkKNSLALS protein stabilization; activity, inhibited transcription, altered 19887647; 29100376 3 1 0 K302/303A mutants are more active then wt protein at low concentration of E2 +Atoh1 ATOH1 Cell development/differentiation; DNA-binding; Transcription factor P48985 11921 6 C1|6 30.03 cM mouse S328-p 34425604 QEDNSKTsPRSHRSD protein degradation; protein stabilization; molecular association, regulation; ubiquitination cell cycle regulation; cell growth, inhibited; cell differentiation, induced; transcription, inhibited HUWE1(INDUCES) 24960692; 34057742 3 2 0 +Mcu MCU Membrane protein, integral; Membrane protein, multi-pass; Mitochondrial Q3UMR5 215999 10|10 B4 mouse S56-p 27259016 TAHQRPAsWQSVGAA apoptosis, induced 23051746 2 0 0 increase CCDC109A current and myocardial cell death +PEBP1 RKIP Lipid-binding; Protein kinase, regulatory subunit P30086 5037 12q24.23 human T42-p 3189667 DELGKVLtPTQVKNR PBP protein degradation; molecular association, regulation cell cycle regulation; autophagy, induced; apoptosis, induced; signaling pathway regulation RAF1(DISRUPTS) 25104559 1 15 0 activation of the ERK pathway +TTK TTK Cancer Testis Antigen (CTA); EC 2.7.12.1; KINASE; Kinase, protein; Protein kinase, Other; Protein kinase, dual-specificity (non-receptor) P33981 7272 6q14.1 human S345-p 41157083 PLVSDEKsSELIITD intracellular localization; enzymatic activity, induced 26119734 1 1 0 regulates spindle assembly checkpoint and recruitment of SAC proteins +KCNJ1 ROMK Channel, potassium; Membrane protein, integral; Membrane protein, multi-pass P48048 3758 11q24.3 human S201-p 2813508 FSKNAVIsKRGGKLC IRK_C activity, induced; intracellular localization 12221079 3 0 1 +Gata1 GATA1 DNA-binding; Transcription factor P17679 14460 X A1.1|X 3.59 cM mouse S187-p 451237 LSSAAYSsPKFHGSL protein degradation; acetylation; ubiquitination; phosphorylation DNA(INDUCES) 16858405 3 0 0 Phosphorylation and acetylation cause the degradation of acetylated GATA-1; DNA binding is required for MAPK-dependent phosphorylation +TNFRSF1A TNF-R1 Membrane protein, integral; Receptor, cytokine P19438 7132 12p13.31 human T411-p 1868023606 LATWRRRtPRREATL Death molecular association, regulation; phosphorylation apoptosis, induced; signaling pathway regulation GRB2(DISRUPTS) 32159413 1 0 0 decrease ERK, Akt and STAT3 phosphorylation; non-canonical TNF-alpha signaling, necrosis induced +Eif2ak3 PERK EC 2.7.11.1; KINASE; Kinase, protein; Membrane protein, integral; Protein kinase, Other; Protein kinase, Ser/Thr (non-receptor); Translation Q9Z2B5 13666 6|6 C1 mouse T980-p 447936 MPAYATHtGQVGTKL Pkinase apoptosis, induced; translation, inhibited 34244887; 34647267 26 0 0 +FOXO1 FOXO1A DNA-binding; Nuclear receptor co-regulator; Oncoprotein; Transcription factor Q12778 2308 13q14.11 human R251-me 5009205 GKSGKSPrRRAASMD protein stabilization; intracellular localization; phosphorylation apoptosis, induced; transcription, induced 18951090 1 0 0 inhibits S256 phosphorylation +Wnk4 WNK4 EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, Other; Protein kinase, Ser/Thr (non-receptor) Q80UE6 69847 11|11 D mouse K384-ub 40323307 NAAQIYRkVTSGTKP Pkinase protein degradation 23576762 1 1 0 regulates electrolyte homeostasis and involved in Pseudohypoaldosteronism type II (PHAII) pathogenesis +Mlxipl ChREBP Transcription factor Q8VIP2 171078 12q12 rat S140-p 2103610 QYVQRRKsPVCGFVT molecular association, regulation; intracellular localization; activity, inhibited transcription, altered 14-3-3 beta(INDUCES); KPNA2(DISRUPTS) 18606808; 21665952 3 1 0 inhibits nuclear localization of ChREBP under low glucose conditions +BIN1 BIN1 Adaptor/scaffold; Cytoskeletal; Tumor suppressor; Vesicle O00499 274 2q14.3 human T348-p 7532308 VPPPPKHtPSKEVKQ molecular association, regulation; protein conformation signaling pathway regulation Tau(INDUCES) 31065832 1 7 4 Tau phosporylation-dependent interaction +Stxbp5 STXBP5 Vesicle Q8K400 78808 10|10 A1 mouse K285-sm 31957311 TPHGKQLkDGKKPEP LLGL neural plasticity 24614299 1 0 0 +Nos3 eNOS Amino Acid Metabolism - arginine and proline; EC 1.14.13.39; Oxidoreductase P70313 18127 5 A3|5 11.32 cM mouse T494-p 447885 AGITRKKtFKEVANA enzymatic activity, inhibited 34222255 82 2 1 +AKT1 Akt1 EC 2.7.11.1; KINASE; Kinase, protein; Oncoprotein; Protein kinase, AGC; Protein kinase, Ser/Thr (non-receptor) P31749 207 14q32.33 human Y176-p 14515900 EKATGRYyAMKILKK Pkinase intracellular localization; enzymatic activity, induced cell cycle regulation; transcription, altered 20333297 3 1 0 membrane localization +USP13 USP13 DEUBIQUITINASE; EC 3.4.19.12; Protease; Ubiquitin conjugating system; Ubiquitin-specific protease Q92995 8975 3q26.33 human Y708-p 1868989003 EPLTMPGyGGAASAG UCH molecular association, regulation carcinogenesis, induced; cell growth, induced; transcription, induced; signaling pathway regulation Myc(INDUCES) 32453420 1 1 0 inhibits ubiquitination and stabilizes c-Myc, regulates CLK3/USP13/c-Myc signaling +POLI POLI DNA repair, damage; EC 2.7.7.7; Transferase Q9UNA4 11201 18q21.2 human K511-ub 21181888 LDTTNFSkEKDINEF protein degradation 26370087 1 3 0 +UBA52-RPS27A-UBB-UBC ubiquitin Ubiquitin-like modifier P62991 mouse K27-ub 3931595 SDTIENVkAKIQDKE ubiquitin protein degradation; ubiquitination cell cycle regulation; autophagy, induced; cell growth, inhibited; transcription, inhibited 31127032; 35900990 30 23 142 USP22 promotes the degradation of NLRP3 via ATG5-mediated autophagy; impairs NFAT recruitment and transcription of NFAT-targeted genes +HDAC8 HDAC8 DEACETYLASE; Deacetylase; EC 3.5.1.98; Hydrolase Q9BY41 55869 Xq13.1 human S39-p 450667 AKIPKRAsMVHSLIE Hist_deacetyl acetylation; enzymatic activity, inhibited; protein conformation 14701748; 15242608; 31633931 3 0 2 Crystalographic data suggests how phosphorylation of S39 alters conformation and negatively regulate HDAC8 activity.; regulates deacetylation +KCNC4 Kv3.4 Channel, potassium; Membrane protein, integral; Membrane protein, multi-pass Q03721 3749 1p13.3 human S8-p 451075 MISSVCVsSYRGRKS Potassium_chann receptor inactivation, altered 9649584 1 1 0 +PRKAA1 AMPKA1 Autophagy; EC 2.7.11.1; EC 2.7.11.26; EC 2.7.11.27; EC 2.7.11.31; KINASE; Kinase, protein; Protein kinase, CAMK; Protein kinase, Ser/Thr (non-receptor) Q13131 5562 5p13.1 human S467-p 7445995 LQLYQVDsRTYLLDF AdenylateSensor enzymatic activity, inhibited; phosphorylation carcinogenesis, induced; cell motility, induced; cell growth, induced 31358902 1 2 0 inhibits phosphorylation at T172 +Cat Catalase Amino Acid Metabolism - tryptophan; Apoptosis; EC 1.11.1.6; Endoplasmic reticulum; Energy Metabolism - methane; Hydrolase; Mitochondrial; Oxidoreductase P24270 12359 2 E2|2 54.43 cM mouse Y231-p 450444 NADGEAVyCKFHYKT Catalase protein degradation; enzymatic activity, induced 12950161 2 9 310 +Lat2 LAB Adaptor/scaffold; Membrane protein, integral Q9JHL0 56743 5|5 G2 mouse Y192-p 450646 SPDEEPDyVNGDVAA LAT2 signaling pathway regulation 22308309 3 1 6 plays a negative role in TCR and FcRI-mediated and no role in LPS-mediated signaling +SIRT2 SIRT2 iso2 DEACETYLASE; Deacetylase; EC 3.5.1.- Q8IXJ6-2 22933 19q13.2 human K340-sm 1881502501 KKSPPPAkDEARTTE enzymatic activity, inhibited carcinogenesis, inhibited 33316537 1 0 0 SIRT2 is the deacetylase of P38 and its enzyme activity is inhibited by its SUMOylation, SUMOylation inhibits the carcinogenic phenotype in neurblastoma cells and is a tumor suppressor in mice +SNAP25 SNAP-25 Vesicle P60880 6616 20p12.2 human S187-p 448668 RIMEKADsNKTRIDE activity, induced; molecular association, regulation exocytosis, altered; exocytosis, induced SYT1(DISRUPTS); STX1A(INDUCES) 17325194; 18171919; 22311984 15 1 0 +GJA8 GJA8 Channel, misc.; Membrane protein, integral; Membrane protein, multi-pass P36381 395846 chicken S395-p 9824606 KASSRARsDDLTV__ activity, induced 21454606 1 2 0 enhances Cx50 gap junction coupling +TIRAP TIRAP Adaptor/scaffold P58753 114609 11q24.2 human Y187-p 463810 SGLSRAAyPPELRFM TIR_2 activity, induced; molecular association, regulation; phosphorylation transcription, induced TLR4(DISRUPTS); MYD88(DISRUPTS); Btk(INDUCES); P38A(INDUCES) 16439361; 18070880; 35379857 3 0 0 +TNIK TNIK EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, STE; Protein kinase, Ser/Thr (non-receptor) Q9UKE5 23043 3q26.2-q26.31 human S764-p 451976 RTRVRANsKSEGSPV activity, induced; intracellular localization cell growth, induced; transcription, induced 20530691; 30901730 2 23 23 +FOXO1 FOXO1A DNA-binding; Nuclear receptor co-regulator; Oncoprotein; Transcription factor Q12778 2308 13q14.11 human S416-p 478368 PPNTSLNsPSPNYQK intracellular localization transcription, altered 20061393 4 1 0 multiple site mutant (8A) +JUP CTNNG Cytoskeletal; Motility/polarity/chemotaxis P14923 3728 17q21.2 human Y133-p 456971 AIVHLINyQDDAELA molecular association, regulation transcription, induced TCF4(DISRUPTS); CTNNA1(DISRUPTS); Desmoplakin(INDUCES) 14517306 1 1 1 +Mip AQP0 Channel, misc.; Membrane protein, integral; Membrane protein, multi-pass; Transporter, aquaporin family P51180 17339 10 D3|10 76.49 cM mouse S235-p 450116 KSVSERLsILKGARP molecular association, regulation Calmodulin(DISRUPTS) 22095752 6 9 0 +TAGLN TAGLN Actin-binding; Motility/polarity/chemotaxis; Nuclear receptor co-regulator Q01995 6876 11q23.3 human K108-ub 1881229501 AEDYGVIkTDMFQTV protein degradation; ubiquitination 33771884 1 0 0 +Irs1 IRS1 Adaptor/scaffold; Motility/polarity/chemotaxis P35569 16367 1 C5|1 42.0 cM mouse S408-p 454417 CLFPRRSsASVSGSP activity, inhibited 15485932 3 0 0 +STAT1 STAT1 DNA-binding; Transcription factor P42224 6772 2q32.2 human R31-m1 476759 DSFPMEIrQYLAQWL STAT_int molecular association, regulation transcription, induced; transcription, altered PIAS1(DISRUPTS); PTPN2(INDUCES) 11257227; 12171910 2 0 0 modulates the duration of STAT1 Y701 phosphorylation +PKD2 PKD2 Channel, cation; Membrane protein, integral; Membrane protein, multi-pass Q13563 5311 4q22.1 human S801-p 15702202 SSLPRPMsSRSFPRS activity, induced cell cycle regulation 20881056 2 0 0 regulates ATP-induced calcium release +Pcbp1 hnRNP E1 RNA splicing; RNA-binding; Translation P60335 23983 6|6 D1 mouse S43-p 13258708 VKRIREEsGARINIS KH_1 translation, altered EEF1A1(DISRUPTS) 20154680; 21329880 3 0 3 +H4c2 H4 DNA-binding P62806 326620 13|13 A3.1 mouse R3-m2 477687 _____SGrGKGGKGL chromatin organization, altered; transcription, inhibited 17967893 10 2 0 +Zc3hc1 NIPA Cell cycle regulation; Ubiquitin conjugating system Q80YV2 232679 6|6 A3.3 mouse S358-p 483339 TRSWESSsPVDRPEL molecular association, regulation cell cycle regulation CUL1(DISRUPTS) 22955283 2 24 11 ERK2 phosphorylation at G2/M is sufficient dissociation of SCF core complex at G2/M. +SIRT3 SIRT3 DEACETYLASE; Deacetylase; EC 3.5.1.-; Mitochondrial Q9NTG7 23410 11p15.5 human T150-p 41655507 MVGAGIStPSGIPDF SIR2 enzymatic activity, induced apoptosis, inhibited 26141949 1 0 0 +Crmp1 CRMP-1 Cell development/differentiation; Cytoskeletal; Hydrolase P97427 12933 5 B3|5 19.96 cM mouse S522-p 1295503 PAPSAKSsPSKHQPP phosphorylation 29758318 4 12 7 S522A KI mice +Ctcf CTCF C2H2-type zinc finger protein; Transcription factor; Tumor suppressor Q61164 13018 8|8 D3 mouse K74-sm 6124703 DPTLLQMkTEVMEGT transcription, inhibited 19029252 2 1 0 +Map1s BPY2-IP1 Apoptosis; Microtubule-binding Q8C052 270058 8|8 B3.3 mouse S812-p 476391 GDRNRPLsARSEPAD cytoskeletal reorganization 30266824 3 6 0 inhibit microtubule binding +CNGA1 CNGA1 Channel, cation; Membrane protein, integral; Membrane protein, multi-pass Q00194 281700 cow Y498-p 450319 LKLQPQVySPGDYIC cNMP_binding activity, inhibited; protein conformation 10366613; 23032687 3 0 0 Phosphorylation promotes channel opening.; inhibits channel activity +HBP1 HBP1 DNA-binding; Transcription factor O60381 26959 7q22.3 human K297-ac 25171015 GLLTVECkLDHPFYV AXH transcription, inhibited 23249948 2 0 0 acetylation of the five sites induces transcriptional repression of the DNMT1 gene, regulates cellular senescence +Prkcg PKCG EC 2.7.11.13; KINASE; Kinase, protein; Protein kinase, AGC; Protein kinase, Ser/Thr (non-receptor) P63318 18752 7 A1|7 1.93 cM mouse T514-p 451041 FPGSTTRtFCGTPDY Pkinase intracellular localization; phosphorylation; enzymatic activity, induced exocytosis, induced 27531930; 35977516 6 45 45 +CUX1 CUTL1 DNA-binding; Membrane protein, integral; Transcription factor P39880 1523 7q22.1 human S1215-p 460700 AYMKRRHsSVSDSQP molecular association, regulation cell motility, altered; transcription, inhibited DNA(DISRUPTS) 16574653 2 4 6 +Traf1 TRAF1 Adaptor/scaffold; Apoptosis P39428 22029 2|2 B mouse S139-p 26331402 MALERNLsELQLQAA molecular association, regulation signaling pathway regulation TNF-R2(INDUCES); TBK1(DISRUPTS) 18429822; 23376065 2 0 0 TNF-R2 regulation of IKK and JNK pathways; regulates association of TBK1 with TNFRSF9 and NFkB activation +Ripk1 RIPK1 EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, Ser/Thr (non-receptor); Protein kinase, TKL Q60855 19766 13 A3.3|13 14.01 cM mouse S334-p 4728178 VPLPPSRsNSEQPGS molecular association, regulation; enzymatic activity, induced RIPK3(INDUCES) 28842570 2 3 0 necroptosis +MBD4 MBD4 Apoptosis; DNA repair, damage; Deoxyribonuclease; EC 3.2.2.- O95243 8930 3q21.3 human S165-p 22730001 CSMAALTsHLQNQSN enzymatic activity, induced DNA repair, induced 19829383 1 0 0 +RPA1 RPA1 DNA-binding P27694 6117 17p13.3 human S384-p 3189442 AIKGARVsDFGGRSL REPA_OB_2 molecular association, regulation cell cycle regulation; apoptosis, inhibited SHFM1(INDUCES) DNA(DISRUPTS) 37230964 1 18 4 +ACACA ACC1 Carbohydrate Metabolism - propanoate; Carbohydrate Metabolism - pyruvate; EC 6.3.4.14; EC 6.4.1.2; Ligase; Lipid Metabolism - fatty acid biosynthesis Q13085 31 17q12 human S1263-p 463821 FSDSPPQsPTFPEAG ACC_central molecular association, regulation; enzymatic activity, inhibited; protein conformation; phosphorylation BRCA1(INDUCES) 16698035; 19061860; 29899443 2 18 2 +Stat5b STAT5B DNA-binding; Oncoprotein; Transcription factor P52632 25126 10q31 rat Y699-p 448198 TAKAADGyVKPQIKQ molecular association, regulation; intracellular localization DNA(INDUCES) 12621061 45 45 2242 +H3c1 H3 DNA-binding P68433 360198 13|13 A3.1 mouse K27-m2 1308912 LATKAARkSAPATGG Histone endocytosis, altered; chromatin organization, altered; cell adhesion, altered; transcription, inhibited 16682010; 16717091; 18039862; 19567879; 20561915; 33195484 42 21 7 axon guidance +NHERF2 NHERF-2 Adaptor/scaffold Q15599 9351 16p13.3 human S303-p 9765067 QESGLHLsPTAAEAK EBP50_C molecular association, regulation; intracellular localization signaling pathway regulation Ezrin(DISRUPTS) 26251448; 26310448 2 10 0 +SRPK1 SRPK1 EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, CMGC; Protein kinase, Ser/Thr (non-receptor) Q96SB4 6732 6p21.31 human S408-p 1872827400 QNGDSSTsQETDSCT intracellular localization 33808326 1 0 0 +SMYD3 SMYD3 EC 2.1.1.43; METHYLTRANSFERASE; Methyltransferase; Methyltransferase, protein lysine; UBIQUITIN LIGASE; Ubiquitin ligase Q9H7B4 64754 1q44 human Y239-p 4145500 GEELTICyLDMLMTS SET methylation; enzymatic activity, induced 16805913 1 0 0 induces histone methylation +MYC Myc DNA-binding; Nucleolus; Oncoprotein; Transcription factor P01106 4609 8q24.21 human K332-ac 458889 AAPPSTRkDYPAAKR Myc_N molecular association, regulation ZBTB17(INDUCES) 16126174 2 2 0 induces association with ZBTB17 on specific target promoters +Tbk1 TBK1 EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, Other; Protein kinase, Ser/Thr (non-receptor) Q9WUN2 56480 10|10 D2 mouse K241-ac 56403910 MYKIITGkPSGAISG Pkinase enzymatic activity, inhibited 27240213 2 2 0 +NEDD1 NEDD1 Cell cycle regulation Q8NHV4 121441 12q23.1 human S377-p 12737836 EKAGLPRsINTDTLS intracellular localization cytoskeletal reorganization 22818914 2 6 0 recruitment of NEDD1 and gamma-tubulin to the centrosome during mitosis +Fbxo43 FBX43 Unknown function Q8CDI2 78803 15|15 B3.1 mouse T176-p 13419500 FSQHKTStIEDSKDN molecular association, regulation PLK1(INDUCES) 26459104 2 0 0 meiotic maturation +EIF2AK2 PKR EC 2.7.10.2; EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, Other; Protein kinase, Ser/Thr (non-receptor); Protein kinase, tyrosine (non-receptor); Translation P19525 5610 2p22.2 human Y162-p 458272 QLAAKLAyLQILSEE dsrm enzymatic activity, induced translation, altered; cell growth, altered 16373505 1 0 0 +RAPH1 RAPH1 Adaptor/scaffold; Motility/polarity/chemotaxis Q70E73 65059 2q33.2 human Y366-p 54363504 LFKNPQNyLLGKKET RA molecular association, regulation cell motility, induced 26996666 1 0 0 Lpd-Scar/WAVE interaction is positively regulated by c-Abl and c-Src, breast cancer cell invasion +Runx2 AML3 iso5 DNA-binding; Transcription factor Q08775-5 12393 17 B3|17 21.33 cM mouse K240-ub 1873375614 EPRRHRQkLDDSKPS cell differentiation, induced; transcription, induced 28500134 1 0 0 +RUNX1 AML1 DNA-binding; Oncoprotein; Transcription factor Q01196 861 21q22.12 human K43-ub 22081854 AGAALAGkLRSGDRS protein degradation; molecular association, regulation; intracellular localization carcinogenesis, inhibited; cell growth, inhibited; transcription, altered; transcription, inhibited TAF1(INDUCES) 28536267; 31664040 2 6 0 deposition of AML1-ETO at a subset of AE target genes and allows AE to control its target gene expression. +FLII FLI Actin-binding; Nuclear receptor co-regulator Q13045 2314 17p11.2 human T818-p 25787600 LHRPRHAtVSRSLEG Gelsolin transcription, induced 19293151 2 0 0 may induce transcription of the estrogen receptor +RACK1 RACK1 Adaptor/scaffold; G protein; G protein, heterotrimeric; G protein, heterotrimeric beta; Motility/polarity/chemotaxis; Nuclear receptor co-regulator P63244 10399 5q35.3 human Y228-p 450543 LNEGKHLyTLDGGDI WD40 protein stabilization; molecular association, regulation; ubiquitination; intracellular localization carcinogenesis, inhibited; cell adhesion, induced; cell motility, inhibited; endocytosis, inhibited Src(NOT_REPORTED) 12400005; 21685945 3 2 4 decreases phosphorylation of E-cadherin, B-catenin, p120 catenin and actin and localises them to cell-to-cell contacts, prevents ubiquitination of E-cadherin further inducing its stabilization, inhibits E-cadherin endocytosis +Mtor mTOR Autophagy; EC 2.7.11.1; KINASE; Kinase, protein; Motility/polarity/chemotaxis; Protein kinase, Ser/Thr (non-receptor); Protein kinase, atypical Q9JLN9 56717 4 E2|4 78.76 cM mouse S2159-p 20473601 RIQSIAPsLQVITSK phosphorylation; enzymatic activity, induced signaling pathway regulation 34245780 3 1 1 induces AKT phosphorylation and mTORC2 and 1 signaling +Cacna1c CACNA1C Channel, calcium; Membrane protein, integral; Membrane protein, multi-pass Q01815 12288 6 F1|6 55.86 cM mouse S1897-p 455278 ASLGRRAsFHLECLK CAC1F_C activity, induced; molecular association, regulation; activity, inhibited; phosphorylation ADRB2(DISRUPTS); CACNA1C(INDUCES) 27103070; 36345826 31 3 0 +AKR1C1 AKR1C1 EC 1.1.1.112; EC 1.1.1.149; EC 1.3.1.20; Oxidoreductase; Xenobiotic Metabolism - metabolism by cytochrome P450 Q04828 1645 10p15.1 human K185-ub 12386310 NKPGLKYkPVCNQVE Aldo_ket_red molecular association, regulation carcinogenesis, induced; cell motility, induced; transcription, induced STAT3(INDUCES) 32104503 1 3 7 pro-metastatic, induces transcription of metastasis-related target genes (SOX2 and TWIST) +Ntrk2 TrkB EC 2.7.10.1; KINASE; Kinase, protein; Membrane protein, integral; Protein kinase, TK; Protein kinase, tyrosine (receptor) P15209 18212 13 B1|13 31.2 cM mouse Y433-p 1872544500 NREHLSVyAVVVIAS molecular association, regulation; intracellular localization neural plasticity; signaling pathway regulation TrkB(INDUCES); Fyn(INDUCES) Other(INDUCES) 33606976 1 0 0 induces binding to cholesterol and fluoxetine, induces BDNF signaling +Pld1 PLD1 iso2 EC 3.1.4.4; Lipid Metabolism - ether lipid; Lipid Metabolism - glycerophospholipid; Motility/polarity/chemotaxis; Phospholipase P70496-2 25096 2q24 rat S2-p 448572 ______MsLRSEARV enzymatic activity, induced 10441128; 10788479 4 2 0 +Mapkapk5 MAPKAPK5 EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, CAMK; Protein kinase, Ser/Thr (non-receptor); Tumor suppressor O54992 17165 5|5 F mouse S115-p 18704700 GELFHRIsQHRHFTE Pkinase protein stabilization; molecular association, regulation; intracellular localization transcription, induced; signaling pathway regulation ERK3(INDUCES) 32139423 2 0 0 induces Atg1 expression, regulates ERK3/MK5 pathway +JAK3 JAK3 EC 2.7.10.2; KINASE; Kinase, protein; Protein kinase, TK; Protein kinase, tyrosine (non-receptor) P52333 3718 19p13.11 human Y785-p 450358 NSLISSDyELLSDPT molecular association, regulation SH2-B-beta(INDUCES) 15121872 3 11 63 +NDE1 NUDE1 iso1 Cell cycle regulation; Cytoskeletal; Microtubule-binding Q9NXR1-1 54820 16p13.11 human T243-p 469634 LDDSTGGtPLTPAAR NUDE_C molecular association, regulation; intracellular localization ZNF365(DISRUPTS) 16682949 1 11 16 +CXCR4 CXCR4 GPCR, family 1; Membrane protein, integral; Membrane protein, multi-pass; Receptor, GPCR P61073 7852 2q22.1 human S325-p 3849622 TSVSRGSsLKILSKG receptor desensitization, induced; receptor internalization, induced; protein degradation; molecular association, regulation; enzymatic activity, induced; activity, induced; ubiquitination; intracellular localization endocytosis, induced ITCH(INDUCES) 19116316; 30327409; 30936203; 34973340 11 12 6 +Cttn Cortactin Actin-binding; Cytoskeletal; Motility/polarity/chemotaxis Q60598 13043 7|7 F5 mouse Y499-p 57807005 TAIALYDyQAAGDDE SH3_9 molecular association, regulation MTUS2(DISRUPTS) 27451391 2 0 0 Y497, Y499, Y541 are major residues for interaction +DCK DCK EC 2.7.1.74; Kinase, other; Nucleotide Metabolism - purine; Nucleotide Metabolism - pyrimidine P27707 1633 4q13.3 human S15-p 460586 SCPSFSAsSEGTRIK phosphorylation 20544527 4 8 6 regulates phosphorylation of S74 +Itgb1 ITGB1 Cell adhesion; Cell surface; Membrane protein, integral; Motility/polarity/chemotaxis; Receptor, misc. P09055 16412 8|8 E2 mouse T788-p 448600 PIYKSAVtTVVNPKY Integrin_b_cyt molecular association, regulation; activity, inhibited exocytosis, induced; cell growth, induced; cell differentiation, induced; cytoskeletal reorganization; cell adhesion, altered; transcription, altered; cell adhesion, inhibited FN1(DISRUPTS); kindlin-2(DISRUPTS); SNX17(DISRUPTS) 19555977; 24719112; 34996844; 35090553; 9512507 15 2 1 The TT788-9AA mutant is defective in mediating cell attachment and does not contribute to fibronectin fibril formation. +Il6st gp130 Membrane protein, integral; Receptor, cytokine Q00560 16195 13 D2.2|13 63.73 cM mouse Y812-p 450054 EILPRQPyFKQNCSQ transcription, altered; signaling pathway regulation 36947594 3 0 1 regulates Src and MAPK/ERK signaling +RRN3 TIF1A Nucleolus; Transcription initiation complex Q9NYV6 54700 16p13.11 human S635-p 11315000 DTHFRSPsSSVGSPP activity, inhibited transcription, inhibited; transcription, altered TAF1C(DISRUPTS) 19815529; 28835357 2 2 0 inhibits transcription complex formation; suppresses pre-rRNA synthesis, protects against ER stress and cell death +SPRED1 SPRED1 Inhibitor Q7Z699 161742 15q14 human S105-p 36131862 KFGLTFQsPADARAF WH1 molecular association, regulation carcinogenesis, induced; cell growth, induced; signaling pathway regulation NF1(DISRUPTS) 32697994 1 2 0 regulates Ras-GTP signaling +Nkx3-2 NKX3-2 Cell development/differentiation; DNA-binding; Transcription factor P97503 12020 5 B3|5 22.58 cM mouse S148-p 20473603 EAPVRSDsEMSASVS molecular association, regulation; ubiquitination apoptosis, inhibited BTRC(INDUCES) 21606193 1 1 0 phosphorylation of S148/S168 causes ubiquitination of IkB-alpha. +Hoxb13 HOXB13 DNA-binding; Transcription factor P70321 15408 11 D|11 59.63 cM mouse S204-p 25295063 KAAFAEPsVQHPPPD intracellular localization cell cycle regulation; cell growth, altered 32499640 1 0 1 +RBBP8 CtIP EC 3.1.-.-; Transcription, coactivator/corepressor Q99708 5932 18q11.2 human S745-p 448392 SCLADSFsQAADEEE molecular association, regulation; enzymatic activity, induced BRCA1(DISRUPTS) 10910365; 24837676 2 1 2 +TOB1 TOB1 Adaptor/scaffold; Cell cycle regulation P50616 10140 17q21.33 human T172-p 1869290800 PTFMPRStQPLTFTT carcinogenesis, induced; cell motility, induced; cell growth, induced 31497236 1 1 0 +AGO2 AGO2 EC 3.1.26.n2; RNA processing; RNA-binding Q9UKV8 27161 8q24.3 human S834-p 40509024 GSHTSGQsNGRDHQA molecular association, regulation; activity, inhibited transcription, inhibited RNA(DISRUPTS) 28114302 2 2 0 regulates miRNA silencing +BANF1 BAF DNA-binding O75531 8815 11q13.1 human K6-sm 1877203102 __MTTSQkHRDFVAE BAF molecular association, regulation; intracellular localization cell cycle regulation lamin A/C(INDUCES); PCNA(INDUCES) DNA(INDUCES) 32332162 1 0 0 nuclear localization +SAFB SAFB1 DNA-binding; Nuclear receptor co-regulator; RNA-binding Q15424 6294 19p13.3 human K294-sm 9859930 DSLLAVVkREPAEQP molecular association, regulation transcription, inhibited HDAC3(INDUCES) 21527249 1 6 0 +RRN3 TIF1A Nucleolus; Transcription initiation complex Q9NYV6 54700 16p13.11 human S636-p 50680600 THFRSPSsSVGSPPV intracellular localization 26506235 1 0 0 nuclear localization +ELK3 ELK3 DNA-binding; Transcription factor P41970 2004 12q23.1 human K162-sm 3818700 PDAFKAIkTEKLEEP transcription, inhibited 15580297 1 1 0 +NF1 NF1 iso2 GAP; GAP, Ras; Motility/polarity/chemotaxis; Nucleolus; Tumor suppressor P21359-2 4763 17q11.2 human S2808-p 456895 QKQRSAGsFKRNSIK intracellular localization 26490262 1 8 10 Ran-dependent +Olig2 OLIG2 Oncoprotein; Transcription factor Q9EQW6 50913 16 C3.3|16 52.6 cM mouse S13-p 18357900 SLVSSRPsSPEPDDL cell cycle regulation; cell differentiation, altered; carcinogenesis, altered; cell growth, induced; apoptosis, inhibited; transcription, induced; cell motility, inhibited 21382551; 27396340; 32483381 4 2 0 +Cttn Cortactin Actin-binding; Cytoskeletal; Motility/polarity/chemotaxis Q60598 13043 7|7 F5 mouse S407-p 467687 QTPPASPsPQPIEDR cell cycle regulation; cell motility, altered 18515860 0 22 19 +NF2 Merlin Cytoskeletal; Motility/polarity/chemotaxis; Tumor suppressor P35240 4771 22q12.2 human T230-p 487468 AIRNKKGtELLLGVD FERM_C protein degradation; phosphorylation carcinogenesis, induced; cell motility, induced; cell growth, induced 17891137; 21750658 4 1 0 induces phosphorylation at S518 +WT1 WT1 C2H2-type zinc finger protein; DNA-binding; Nucleolus; Transcription factor; Tumor suppressor P19544 7490 11p13 human S365-p 451117 KDCERRFsRSDQLKR zf-C2H2 transcription, altered 9366517 1 0 0 Phosphorylation of S365 inhibited WT1 DNA-binding, and thereby decreased WT1 transcriptional repression activity. +DCC DCC Immunoglobulin superfamily; Membrane protein, integral; Receptor, misc.; Tumor suppressor P43146 1630 18q21.2 human Y1363-p 1979800 AIEPKVPyTPLLSQP Neogenin_C molecular association, regulation RASA1(INDUCES); Lck(INDUCES); Fyn(INDUCES) 18253061; 26710849 2 0 0 +CASQ2 calsequestrin 2 Calcium-binding P12637 483134 dog S405-p 1868253001 DEESNDDsDDDDE__ intracellular localization 21431367 2 1 0 regulates intracellular trafficking of calsequestrin 2 +LATS2 LATS2 EC 2.7.11.1; KINASE; Kinase, protein; Nuclear receptor co-regulator; Protein kinase, AGC; Protein kinase, Ser/Thr (non-receptor); Tumor suppressor Q9NRM7 26524 13q12.11 human S835-p 28706304 GSHVRQDsMEPSDLW Pkinase activity, induced; phosphorylation; enzymatic activity, induced apoptosis, induced; signaling pathway regulation 23886938; 30800215 2 1 0 Hippo pathway; Chk1-dependent trans-autophosphorylation in SAS cell line; in SAS cell line; enhances p21Cip1 phosphoylation +OTULIN FAM105B EC 3.4.19.12 Q96BN8 90268 5p15.2 human Y56-p 3560103 AEHEEDMyRAADEIE molecular association, regulation carcinogenesis, induced; transcription, induced; signaling pathway regulation; transcription, inhibited RNF31(DISRUPTS); CTNNB1(INDUCES) 24726323; 24726327; 32770022 3 3 20 Wnt/?-catenin pathway +WDCP WDCP Q9H6R7 80304 2p23.3 human S695-p 31855763 SHSPGAVsSLKVFTG molecular association, regulation KIF2A(DISRUPTS); MRE11A(INDUCES) 30297404 1 2 0 mitotic spindle dynamics +SOD2 SOD2 EC 1.15.1.1; Mitochondrial; Oxidoreductase P04179 6648 6q25.3 human K122-ac 475813 GELLEAIkRDFGSFD Sod_Fe_C enzymatic activity, inhibited 28584055 9 6 68 regulates NLRP3 inflammasome assembly formation and activation, cytokine production +ATG16L1 ATG16L1 Adaptor/scaffold; Autophagy; Membrane protein, peripheral Q676U5 55054 2q37.1 human T300-p 54390606 VPQDNVDtHPGSGKE protein stabilization; intracellular localization autophagy, induced 31267703 2 0 0 induces xenophagy +Cpeb1 CPEB RNA-binding; Translation P70166 12877 7|7 D3 mouse T171-p 449610 VRGSRLDtRPILDSR CEBP1_N molecular association, regulation neural plasticity; translation, altered; cytoskeletal reorganization; translation, induced PARN(DISRUPTS) 17567800; 22727665 8 0 0 spine density and shape, long-term depression and motor coordination ; PARN release, polyadenylation +TMIGD2 IGPR-1 Membrane protein, integral Q96BF3 126259 19p13.3 human S220-p 14160579 GKDQRGQsIYSTSFP protein conformation; phosphorylation autophagy, induced; cell growth, induced; cell adhesion, induced; apoptosis, inhibited; cytoskeletal reorganization 27838321; 28920928; 31341021; 32978258 4 2 19 determines the sensitivity of tumor cells to the killing effects of doxorubicin; Blocking the trans-homophilic dimerization of IGPR-1 inhibits IGPR-1 S220 phosphorylation.; inhibition of shear stress?induced actin fiber assembly and endothelial cell remodeling; phosphorylation/activation of AMPK, BECN1 and ULK1 +Oaz2 OAZ2 Inhibitor O08608 18247 9|9 C mouse S186-p 11507801 YPLDQNLsDED____ molecular association, regulation ODC(INDUCES) 19725046 1 0 0 +SENP3 SENP3 DESUMOYLASE; EC 3.4.22.68; Nucleolus; Protease; Sumo-specific protease Q9H4L4 26168 17p13.1 human S139-p 36438204 AFRMLLYsKSTSLTF molecular association, regulation; intracellular localization NPM1(INDUCES) 25288641 1 1 0 ribosome biogenesis-28S rRNA maturation +Ckm CKM Amino Acid Metabolism - arginine and proline; EC 2.7.3.2; KINASE; Kinase, other P00564 24265 1q21 rat S128-p 5410301 LDPNYVLsSRVRTGR activity, inhibited 18979206 1 3 0 +EGFR EGFR EC 2.7.10.1; KINASE; Kinase, protein; Membrane protein, integral; Oncoprotein; Protein kinase, TK; Protein kinase, tyrosine (receptor) P00533 1956 7p11.2 human Y727-p 457949 SGAFGTVyKGLWIPE PK_Tyr_Ser-Thr molecular association, regulation SHC1(INDUCES) 16729043 2 15 150 +MC4R MC4R GPCR, family 1; Membrane protein, integral; Membrane protein, multi-pass; Receptor, GPCR P32245 4160 18q21.32 human S330-p 449103 GGLCDLSsRY_____ receptor internalization, altered 12639913 2 0 0 +ESR1 ER-alpha DNA-binding; Nuclear receptor; Transcription factor P03372 2099 6q25.1-q25.2 human K302-ac 459091 PLMIKRSkKNSLALS activity, induced transcription, altered 11279135 2 0 0 suppresses ligand sensitivity +RHOT1 RHOT1 EC 3.6.5.-; G protein; G protein, monomeric; G protein, monomeric, Rho; Hydrolase; Membrane protein, integral; Mitochondrial Q8IXI2 55288 17q11.2 human K187-ub 7287869 EMKPACIkALTRIFK protein degradation; intracellular localization autophagy, induced 34152608 1 8 9 induces mitophagy by recruiting Parkin to mitochondria +SMAD2 SMAD2 DNA-binding; Transcription factor Q15796 4087 18q21.1 human S240-p 450145 SDQQLNQsMDTGSPA molecular association, regulation; intracellular localization SMAD3(INDUCES) 11027280; 11879191 2 0 0 S240-p translocates to the nucleus. +Ppargc1a PGC-1 alpha Nuclear receptor co-regulator; Transcription, coactivator/corepressor O70343 19017 5|5 C1 mouse S241-p 13861602 KCASKKKsHTQPQSQ protein stabilization; intracellular localization transcription, induced 20351112; 23201126 2 0 0 +Lipe HSL EC 3.1.1.79; Lipase P54310 16890 7 A3|7 13.78 cM mouse S651-p 450195 GFHPRRSsQGVLHMP Abhydrolase_3 activity, induced; intracellular localization; enzymatic activity, induced 21186937; 24273196; 30126894; 33888116 29 14 16 +NR3C1 GR DNA-binding; Mitochondrial; Nuclear receptor; Transcription factor P04150 2908 5q31.3 human K495-ac 3287301 LEARKTKkKIKGIQQ receptor desensitization, induced; molecular association, regulation transcription, induced; transcription, inhibited NFkB-p65(DISRUPTS) DNA(DISRUPTS) 16380507; 19141540 2 0 0 +Sfn 14-3-3 sigma Adaptor/scaffold O70456 55948 4 D2.3|4 66.25 cM mouse S186-p 456054 FHYEIANsPEEAISL 14-3-3 molecular association, regulation Abl(DISRUPTS) 19220809 5 0 0 +Tsc2 TSC2 Cell cycle regulation; GAP; GAP, misc.; Nuclear receptor co-regulator; Tumor suppressor Q61037 22084 17 A3.3|17 12.41 cM mouse T1465-p 448546 GLRPRGYtISDSAPS activity, inhibited; enzymatic activity, induced 36842323 64 14 48 induces mTORC1 activity +MAP2K6 MKK6 EC 2.7.12.2; KINASE; Kinase, protein; Protein kinase, STE; Protein kinase, dual-specificity (non-receptor) P52564 5608 17q24.3 human Y219-p 1186001 IDAGCKPyMAPERIN Pkinase molecular association, regulation RAC1(INDUCES) 17854274 1 0 0 enhances Rac-GTPase activity and inhibits NADPH oxidase activity in vivo +NEDD9 Cas-L Adaptor/scaffold; Motility/polarity/chemotaxis Q14511 4739 6p24.2 human S369-p 9471800 VDGINRLsFSSTGST protein degradation cell motility, inhibited FAK(DISRUPTS) 19539609; 25817040 2 2 0 +ACE ACE EC 3.4.15.1; Membrane protein, integral; Protease P12821 1636 17q23.3 human S1299-p 450699 SHGPQFGsEVELRHS protein degradation; molecular association, regulation; intracellular localization; phosphorylation exocytosis, altered; transcription, induced ACE(INDUCES); MYH9(INDUCES) DNA(INDUCES) 12386153; 14615289; 15569856; 16186248; 16476786; 21901117 7 17 15 +PAX8 PAX8 Transcription factor Q06710 7849 2q14.1 human T277-p 1877752106 TLDDGKAtLTPSNTP protein stabilization 31391550 1 0 0 +Mvk MVK EC 2.7.1.36; Kinase, other; RNA-binding; Secondary Metabolites Metabolism - terpenoid backbone biosynthesis; Translation P17256 rat K256-sm 12723514 GVRSRLIkFPEIMAP translation, inhibited 20167237 1 0 0 +HBP1 HBP1 DNA-binding; Transcription factor O60381 26959 7q22.3 human K398-ub 573758320 FARSGFSkNCGSPGS protein degradation carcinogenesis, induced; cell growth, induced; transcription, induced; DNA repair, inhibited 30816344 1 3 0 MDM2-induced genomic instability by ubiquitinating HBP +THRA TR-alpha iso2 DNA-binding; Nuclear receptor; Transcription factor P10827-2 7067 17q21.1 human K283-sm 27490404 LSGEMAVkREQLKNG Hormone_recep cell growth, induced; cell differentiation, induced; transcription, induced; signaling pathway regulation 25572392 4 0 0 induces Wnt/?-catenin signaling pathway +WEE1 Wee1 EC 2.7.10.2; KINASE; Kinase, protein; Protein kinase, Other; Protein kinase, Ser/Thr (non-receptor); Protein kinase, tyrosine (non-receptor) P30291 7465 11p15.4 human S139-p 449250 YFLGSSFsPVRCGGP protein degradation; molecular association, regulation; phosphorylation cell cycle regulation PLK1(INDUCES) 23051732 1 28 2 primes PLK1 phosphorylation +PACSIN2 PACSIN2 Adaptor/scaffold; Motility/polarity/chemotaxis Q9UNF0 11252 22q13.2 human S313-p 4786393 ADLNRTLsRREKKKA molecular association, regulation; ubiquitination cell motility, induced; cytoskeletal reorganization; transcription, inhibited 31801866; 37296607 3 7 20 NS5A protein from Hepatitis C virus inhibits phosphorylation of this site which promotes its interaction with PACSIN2 domain I; inhibits ubiquitination and degradation of N-WASP +Ptpn6 SHP-1 EC 3.1.3.48; Motility/polarity/chemotaxis; PHOSPHATASE; Protein phosphatase, tyrosine (non-receptor) P29351 15170 6 F2|6 59.17 cM mouse Y208-p 3712666 EASGAFVyLRQPYYA protein processing 18617527 1 0 0 promotes N terminal cleavage to 45 kDa form +NFATC4 NFAT3 DNA-binding; Transcription factor Q14934 4776 14q12 human S213-p 953804 ASRFGLGsPLPSPRA transcription, induced 17875713 1 13 1 +Map2k1 MEK1 EC 2.7.12.2; KINASE; Kinase, protein; Protein kinase, STE; Protein kinase, dual-specificity (non-receptor) Q01986 170851 8q24 rat T286-p 448286 VEGDAAEtPPRPRTP Pkinase enzymatic activity, inhibited 8114697 8 6 16 +NOTCH1 Notch 1 Membrane protein, integral; Motility/polarity/chemotaxis; Oncoprotein; Receptor, misc.; Transcription factor P46531 4851 9q34.3 human S2439-p 1875193400 SFLSGEPsQADVQPL protein degradation cell cycle regulation 31597699 1 0 0 +Prkd1 PRKD1 Autophagy; EC 2.7.11.13; KINASE; Kinase, protein; Motility/polarity/chemotaxis; Protein kinase, CAMK; Protein kinase, Ser/Thr (non-receptor) Q9WTQ1 85421 6q22 rat S916-p 447632 KALSERVsIL_____ molecular association, regulation; intracellular localization autophagy, induced; transcription, altered KIDINS220(DISRUPTS) 16651260; 18378685; 35760846 43 13 0 induces mitophagy; Pasteurella multocida toxin induced nuclear localization and CREB transactivation +Foxo3 FOXO3A Autophagy; DNA-binding; Oncoprotein; Transcription factor Q9WVH4 56484 10 B2|10 22.79 cM mouse S314-p 449109 DFRSRTNsNASTVSG intracellular localization carcinogenesis, induced; cell growth, induced 12857750; 33795838 5 0 1 +FOXC2 FOXC2 Apoptosis; Cell development/differentiation; DNA-binding; Transcription factor Q99958 2303 16q24.1 human S232-p 3210579 ITKVETLsPESALQG molecular association, regulation transcription, altered DNA(INDUCES) 23878394 1 18 0 implicated in vascular remodeling in vivo +RET Ret EC 2.7.10.1; KINASE; Kinase, protein; Membrane protein, integral; Oncoprotein; Protein kinase, TK; Protein kinase, tyrosine (receptor) P07949 5979 10q11.21 human Y809-p 450701 LIVEYAKyGSLRGFL PK_Tyr_Ser-Thr enzymatic activity, induced cell growth, altered 14711813 2 0 0 +Sort1 SORT1 Membrane protein, integral; Receptor, misc. Q6PHU5 20661 3|3 F2.3-F3 mouse S819-p 468808 KSGYHDDsDEDLLE_ protein stabilization; intracellular localization 28844948 5 43 23 plasma membrane localization +DDX5 DDX5 EC 3.6.4.13; Helicase; Nuclear receptor co-regulator; Nucleolus; RNA splicing; RNA-binding; Spliceosome P17844 1655 17q23.3 human K44-ac 15211502 PGEKLVKkKWNLDEL protein stabilization; molecular association, regulation carcinogenesis, induced; transcription, induced HDAC1(INDUCES); HDAC2(INDUCES) 20663877 1 1 0 +BAG3 BAG3 Apoptosis; Chaperone O95817 9531 10q26.11 human T285-p 467534 GSPARSStPLHSPSP molecular association, regulation; intracellular localization cell cycle regulation; cytoskeletal reorganization HSBP1(DISRUPTS) 27659916; 34685619 2 40 63 +Ptpn1 PTP1B EC 3.1.3.48; Motility/polarity/chemotaxis; PHOSPHATASE; Phosphatase; Protein phosphatase, tyrosine (non-receptor) P20417 24697 3q42 rat Y152-p 449312 ISEDVKSyYTVRQLE Y_phosphatase phosphorylation cell differentiation, inhibited; cell motility, inhibited; transcription, altered; signaling pathway regulation 33511306 5 0 1 Regulates bone regeneration; inhibits phosphorylation of FAK, STAT3, inhibits NOTCH signaling +WRN WRN Cell cycle regulation; DNA repair, damage; DNA-binding; EC 3.6.4.12; Helicase; Nucleolus Q14191 7486 8p12 human K1127-ac 14512100 SGSNISKkSIMVQSP protein stabilization; ubiquitination 20428248 1 1 0 inhibits ubiquitination +IRF5 IRF5 DNA-binding; Transcription factor Q13568 3663 7q32.1 human K412-ub 4666600 DRKPREKkLITVQVV IRF-3 molecular association, regulation; ubiquitination; intracellular localization transcription, induced; transcription, inhibited LYN(INDUCES) 18824541; 27521268 2 1 0 pro-inflammatory cytokine gene transcription; nuclear translocation; inhibition of IRF5 activation by Lyn requires their physical Interaction, Lyn inhibits IRF5 ubiquitination and phosphorylation by protecting IRF5 from each of PTM enzymes +EEF1A1 EEF1A1 Nucleolus; Translation; Translation elongation P68104 1915 6q13 human S21-p 5434136 GHVDSGKsTTTGHLI GTP_EFTU protein degradation; molecular association, regulation; ubiquitination apoptosis, induced EEF1A2(INDUCES) 22378069 1 4 5 +MCM7 MCM7 DNA replication; EC 3.6.4.12; Motility/polarity/chemotaxis P33993 4176 7q22.1 human K449-m2 58123200 CCIDEFDkMAEADRT MCM molecular association, regulation L3MBTL iso4(INDUCES) 23583077 0 1 0 +ATAD5 ATAD5 Q96QE3 79915 17q11.2 human S653-p 3209715 TVPFDSEsPIRMKFT molecular association, regulation BRD4(DISRUPTS) 31875566 1 8 0 +BRAF BRAF EC 2.7.11.1; KINASE; Kinase, protein; Oncoprotein; Protein kinase, Ser/Thr (non-receptor); Protein kinase, TKL P15056 673 7q34 human K578-ub 40212808 SIIHRDLkSNNIFLH PK_Tyr_Ser-Thr carcinogenesis, induced; cell growth, induced; transcription, induced 23907581 1 0 0 phosphorylation at T599 and S602 and K578 ubiquitination mediate ERK activation +MED1 MED1 Nuclear receptor co-regulator; Transcription, coactivator/corepressor Q15648 5469 17q12 human T1457-p 449866 HSKSPAYtPQNLDSE activity, induced; molecular association, regulation; protein stabilization; intracellular localization; phosphorylation carcinogenesis, induced; cell growth, induced; apoptosis, inhibited; transcription, induced; signaling pathway regulation FOXA1(INDUCES); AR(INDUCES) 16314496; 23850489; 25481872; 31466944 7 2 0 increased UBE2C protein expression; induces phosphorylation of itself at T1032 and of AR, regulates AR signaling +Fbxo43 FBX43 Unknown function Q8CDI2 78803 15|15 B3.1 mouse T152-p 50613404 FSPLVTStIKTEDVV molecular association, regulation PLK1(INDUCES) 26459104 1 0 0 meiotic maturation +PDGFC PDGFC Secreted; Secreted, signal peptide Q9NRA1 56034 4q32.1 human K314-sm 3875800 EVLQLRPkTGVRGLH PDGF molecular association, regulation; intracellular localization DNA(INDUCES) 16443219 1 0 0 nuclear localization +TSPYL2 TSPYL2 DNA replication; Transcription regulation Q9H2G4 64061 Xp11.22 human T340-p 12559513 GRLVSHStPIRWHRG NAP cell growth, altered 11395479 1 0 0 +RAD52 RAD52 DNA repair, damage P43351 5893 12p13.33 human K274-ac 971232904 QFRERMEkQQVRVST molecular association, regulation; intracellular localization DNA repair, induced RFA2(INDUCES); RPA3(INDUCES); RAD51(INDUCES); RPA1(INDUCES) 29590107 1 1 0 accumulation of RAD52 at DSB sites +Mecp2 MECP2 Transcription, coactivator/corepressor Q9Z2D6 17257 X A7.3|X 37.63 cM mouse S80-p 452713 AVPEASAsPKQRRSI activity, induced apoptosis, altered; chromatin organization, altered; cell growth, induced; transcription, induced; transcription, altered 19225110; 19820693; 31352003 12 68 1 HSC activation induced; HSC proliferation and collagen expression; Regulation of Liver fibrosis +GALNT2 GALNT2 EC 2.4.1.41; Glycan Metabolism - O-glycan biosynthesis; Membrane protein, integral; Transferase Q10471 2590 1q42.13 human K111-ac 25336503 FNQVESDkLRMDRAI enzymatic activity, inhibited; O-GalNAc glycosylation 21651894 0 1 0 inhibits glycosylation of mucin +Gli2 GLI2 C2H2-type zinc finger protein; Oncoprotein; Transcription factor Q0VGT2 14633 1 E2.3|1 52.17 cM mouse S805-p 1717566 YTVSRRSsGISPYFS sumoylation 22549777 1 5 3 +PLD2 PLD2 EC 3.1.4.4; Lipid Metabolism - ether lipid; Lipid Metabolism - glycerophospholipid; Motility/polarity/chemotaxis; Phospholipase O14939 5338 17p13.2 human Y511-p 10036100 FFWLGKDySNLITKD molecular association, regulation; enzymatic activity, induced cell growth, altered GRB2(INDUCES); CD45(DISRUPTS) 19715678; 20176813 2 1 0 dephosphorylated Y179 and Y511 mediates an induction of cell proliferation +CCDC6 CCDC6 Apoptosis; Cytoskeletal; Oncoprotein Q16204 8030 10q21.2 human S413-p 4957370 SHGITRPsPRRSNSP protein degradation; molecular association, regulation cell cycle regulation FBXW7(INDUCES) 23108047; 25885523 2 7 3 +AMBRA1 AMBRA1 Autophagy; UBIQUITIN LIGASE; Ubiquitin ligase; Vesicle Q9C0C7 55626 11p11.2 human S1043-p 1255792404 CRPEALNsGVEYYWD protein stabilization; molecular association, regulation; protein conformation autophagy, induced LC3B(INDUCES); GABARAP(INDUCES) 30217973 1 0 0 mitophagy induced interaction +KHDRBS1 KHDRBS1 RNA-binding Q07666 10657 1p35.2 human S20-p 457016 RSSGRSGsMDPSGAH neural plasticity; RNA splicing, induced 37595869 2 49 11 +MAPKAPK5 MAPKAPK5 EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, CAMK; Protein kinase, Ser/Thr (non-receptor); Tumor suppressor Q8IW41 8550 12q24.12-q24.13 human S160-p 1876193500 NLLFKDNsLDAPVKL Pkinase enzymatic activity, induced 35064619 1 1 0 +PAK4 PAK4 EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, STE; Protein kinase, Ser/Thr (non-receptor) O96013 10298 19q13.2 human K473-me 1876978900 SKEVPRRkSLVGTPY Pkinase intracellular localization cytoskeletal reorganization; cell motility, inhibited; cell adhesion, inhibited 33051544 1 0 0 decreases formation of filopodia and actin structures, inhibits paxillin localization to focal adhesions, inhibits invasion +Prkca PKCA EC 2.7.11.13; KINASE; Kinase, protein; Oncoprotein; Protein kinase, AGC; Protein kinase, Ser/Thr (non-receptor) P20444 18750 11 E1|11 70.8 cM mouse Y658-p 455927 SDFEGFSyVNPQFVH Pkinase_C molecular association, regulation GRB2(INDUCES) 12881490 5 0 0 +RRAS RRas G protein; G protein, monomeric; G protein, monomeric, Ras; Motility/polarity/chemotaxis P10301 6237 19q13.33 human Y66-p 448122 DPTIEDSyTKICSVD Ras molecular association, regulation cell motility, altered; cytoskeletal reorganization; cell adhesion, altered 10570155; 11682467; 16522685 3 0 0 Y66E blocks activated (38V) R-Ras-induced cell retraction (cells with spikes). Y66F blocks activated R-Ras inhibition of cell migration during ephrin-B1 stimulation (effect present but not as intense in Y66F non-activated R-ras allele). Y66F inhibits ephrin-A1-induced growth cone collapse. +Myocd myocardin Cell development/differentiation; Transcription factor Q8VIM5 214384 11|11 B3 mouse S466-p 3627506 PPISPASsDLSAAGS transcription, inhibited 16141410 1 0 0 +PIAS4 PIAS4 EC 6.3.2.-; Nuclear receptor co-regulator; SUMO LIGASE; SUMO conjugating system; SUMO ligase; Transcription, coactivator/corepressor Q8N2W9 51588 19p13.3 human K35-sm 2293702 GRSKSGLkHELVTRA sumoylation; molecular association, regulation; intracellular localization transcription, induced PML(DISRUPTS) 15831457 1 0 0 induces sumoylation of Tcf-4 +LIG1 LIG1 DNA repair, damage; EC 6.5.1.1; Ligase P18858 3978 19q13.33 human K79-ub 59175203 DEALSPAkGQKPALD protein degradation 27573245 1 1 0 +YBX1 YB-1 RNA processing; RNA splicing; RNA-binding; Transcription factor P67809 4904 1p34.2 human S209-p 7998039 YGRRPQYsNPPVQGE molecular association, regulation; intracellular localization carcinogenesis, induced; cell growth, induced; transcription, induced; signaling pathway regulation DNA(INDUCES) 35008856; 37328464 2 14 25 induces the TOPK/YB1/eEF1A1 signal pathway; prevent nuclear translocation and nuclear import +Plk4 PLK4 EC 2.7.11.21; KINASE; Kinase, protein; Nucleolus; Protein kinase, Other; Protein kinase, Ser/Thr (non-receptor) Q64702 20873 3|3 B mouse T300-p 12654006 TITASSGtSLSGSLL protein degradation; ubiquitination 20100909 2 1 0 +Stx3 STX3 iso2 Cell adhesion; Membrane protein, integral; Vesicle Q64704-2 20908 19|19 A mouse T14-p 31960301 QLKAKQLtQDDDTDE molecular association, regulation; protein conformation exocytosis, induced SNAP-25(INDUCES) 24680688 5 1 0 shift to open conformation-regulates neurotransmitter release efficiency +MYOD1 MyoD DNA-binding; RNA splicing; Transcription factor P15172 4654 11p15.1 human S200-p 452000 YSGDSDAsSPRSNCS Myf5 molecular association, regulation; activity, inhibited transcription, inhibited SUV39H1(INDUCES) DNA(INDUCES) 20026657 1 1 0 MyoD binding to SUV39H1 results in SUV39H1 binding to DNA. +ACTB ACTB Cytoskeletal; Motility/polarity/chemotaxis P60709 60 7p22.1 human S239-p 3147240 SSSSLEKsYELPDGQ Actin phosphorylation cell motility, induced; cell growth, inhibited; cytoskeletal reorganization 37648284 1 25 1 inhibits Rac1/Cdc42 phosphorylation +MAVS MAVS Adaptor/scaffold; Membrane protein, integral Q7Z434 57506 20p13 human S324-gl 1872691002 ASVSTVPsKLPTSSK phosphorylation 31461653 1 1 0 positively regulates phosphorylation of S442 (data from MAVS 7A mutant) +NFKBIB IkB-beta Inhibitor Q15653 4793 19q13.2 human S23-p 447916 WCDSGLGsLGPDAAA protein degradation 8657102 6 0 0 +RACGAP1 MgcRacGAP GAP; GAP, Rac/Rho Q9H0H5 29127 12q13.12 human S170-p 459865 ESLDWDSsLVKTFKL molecular association, regulation; enzymatic activity, induced cell cycle regulation PPP2CA(DISRUPTS) 19468302; 27453045; 35477750 5 4 0 induces Rho GTPase activity +Tsc2 TSC2 Cell cycle regulation; GAP; GAP, misc.; Nuclear receptor co-regulator; Tumor suppressor P49816 24855 10q12 rat T1373-p 469994 SSEGARPtVDLSFQP activity, inhibited; phosphorylation translation, altered; apoptosis, inhibited 16959574 3 11 26 inhibits mTOR signaling. required for Wnt-3a to stimulation phosphorylation of S6K and 4EBP1 and increase protein levels of cyclin D1 and VEGF (cyclin D1 through translation not transcription). +ABRAXAS1 Abraxas DNA repair, damage Q6UWZ7 84142 4q21.23 human S404-p 25173562 MKGFGEYsRSPTF__ molecular association, regulation BRCA1(INDUCES) 26778126 2 6 0 +GMPS GMPS EC 6.3.5.2; Ligase; Nucleotide Metabolism - purine; Oncoprotein; Xenobiotic Metabolism - drug metabolism - other enzymes P49915 8833 3q25.31 human K182-ub 4332244 AGIANESkKLYGAQF GATase intracellular localization apoptosis, inhibited 24462112 1 6 41 +NAA50 NAA50 ACETYLTRANSFERASE; Acetyltransferase; EC 2.3.1.- Q9GZZ1 80218 3q13.31 human K140-ac 475616 ETKKNYYkRIEPADA acetylation; enzymatic activity, induced 19744929 1 1 25 reduces histone acetylation and increases NAT activity, thereby increasing enzyme specificity +Atm ATM DNA repair, damage; EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, Ser/Thr (non-receptor); Protein kinase, atypical; Tumor suppressor Q62388 11920 9 A5.3|9 29.12 cM mouse S1987-p 448797 SPTFEEGsQGTTISS intracellular localization; enzymatic activity, induced DNA repair, induced; chromatin organization, altered 16906133; 17244605; 19047460; 25101980; 33753455 214 24 4 +STAT4 STAT4 DNA-binding; Transcription factor Q14765 6775 2q32.2-q32.3 human S713-p 50800612 SDSTEPHsPSDLLPM molecular association, regulation; enzymatic activity, inhibited transcription, inhibited LIFR(DISRUPTS) 30770344 1 3 0 inhibits STAT3 activity +KCNA3 Kv1.3 Channel, potassium; Membrane protein, integral; Membrane protein, multi-pass P22001 3738 1p13.3 human Y162-p 3820931 SFDAILYyYQSGGRI BTB_2 activity, inhibited 19166614 1 0 0 +Prlr PRLR Membrane protein, integral; Receptor, cytokine Q08501 19116 15 A1|15 5.23 cM mouse Y532-p 3188101 VPETSKEyAKVSGVT molecular association, regulation transcription, altered CISH(INDUCES) 12761205 1 0 0 binding of CISH inhibits STAT5 activation (STAT5 does not bind to this site though) +PSME3 PSME3 Nuclear receptor co-regulator; Protease; Proteasome complex P61289 10197 17q21.31 human S247-p 15413789 EKIKRPRsSNAETLY PA28_beta molecular association, regulation apoptosis, induced DBC-1(INDUCES) 25361978 1 1 0 inhibits SIRT1 to induce phosphorylation of PSME3 +Smarca2 SMARCA2 EC 3.6.1.-; EC 3.6.4.-; Helicase; Nuclear receptor co-regulator; Transcription, coactivator/corepressor Q6DIC0 67155 19 C1|19 21.17 cM mouse K1542-ac 460622 GRDTGKGkKRPNRGK molecular association, regulation; protein conformation cell growth, induced; transcription, inhibited Rb(DISRUPTS) DNA(DISRUPTS) 14657023 1 1 1 +Cap1 CAP1 Actin-binding; Cytoskeletal P40124 12331 4|4 D2.2 mouse S307-p 485063 SAPKPQTsPSPKPAT molecular association, regulation; intracellular localization cytoskeletal reorganization; cell motility, inhibited Cofilin-1(DISRUPTS); ACTA1(INDUCES) 25315833 4 46 29 +Epor EPOR Membrane protein, integral; Receptor, cytokine P14753 13857 9 A3|9 7.93 cM mouse Y425-p 449884 TSPSSFEyTILDPSS molecular association, regulation CISH(INDUCES) 28038963 10 0 0 +Caskin1 CASKIN1 Adaptor/scaffold Q8VHK2 140722 10q12 rat S1258-p 481277 VPLPGPGsPEVKRAH signaling pathway regulation 30411139 0 24 0 +MCL1 MCL1 Apoptosis; Channel, misc.; Inhibitor; Membrane protein, integral; Mitochondrial Q07820 4170 1q21.2 human T68-p 31863755 AGASPPStLTPDSRR protein stabilization 27738316 1 0 1 +H3-3A H3F3A DNA-binding P84243 3020 1q42.12 human K79-m2 18545333 REIAQDFkTDLRFQS Histone molecular association, regulation L3MBTL iso4(INDUCES) 23583077 0 3 2 +Trpm7 ChaK1 Channel, cation; EC 2.7.11.1; KINASE; Kinase, protein; Membrane protein, integral; Membrane protein, multi-pass; Protein kinase, Ser/Thr (non-receptor); Protein kinase, atypical Q923J1 58800 2|2 F1 mouse S1403-p 2512922 PPTKFSVsTPSQPSC molecular association, regulation; intracellular localization 14-3-3 theta(INDUCES) 29866880 2 21 24 S1403 is a stronger interaction site +Piwil1 PIWIL1 Membrane protein, peripheral Q9JMB7 57749 5 G1.3|5 67.86 cM mouse R14-m2 9859901 ARARGRArGQETVQH GAGE molecular association, regulation; intracellular localization TDRKH(INDUCES); TDRD9(INDUCES); TDRD1(INDUCES); TDRD6(INDUCES); TDRD7(INDUCES) 19584108 1 1 0 +FSCN1 fascin Actin-binding; Cytoskeletal; Motility/polarity/chemotaxis Q16658 6624 7p22.1 human T403-p 15720201 GCRKVTGtLDANRSS Fascin protein conformation carcinogenesis, inhibited; cell growth, inhibited; cytoskeletal reorganization; cell motility, inhibited 35219877 1 9 0 +RARA RARA DNA-binding; Nuclear receptor; Oncoprotein; Transcription factor P10276 5914 17q21.2 human K399-sm 10902800 AERVITLkMEIPGSM Hormone_recep intracellular localization transcription, induced 19850744 1 0 0 +Keap1 KEAP1 Endoplasmic reticulum; Motility/polarity/chemotaxis; Transcription regulation; UBIQUITIN LIGASE; Ubiquitin conjugating system Q9Z2X8 50868 9|9 A3 mouse Y85-p 25123100 DVTLQVKyEDIPAAQ BTB protein degradation; ubiquitination; intracellular localization 22448038 1 0 0 required for the nuclear export of KEAP1, Cul3 and Rbx1 +MAVS MAVS Adaptor/scaffold; Membrane protein, integral Q7Z434 57506 20p13 human R52-m1 1881446400 TCTLSGNrDTLWHLF molecular association, regulation RIGI(DISRUPTS) 34171297 1 1 0 abolishes MAVS agregation +DAB2 DAB2 Adaptor/scaffold; Tumor suppressor P98082 1601 5p13.1 human S723-p 18008467 KPAPRQVsLPVTKST molecular association, regulation; intracellular localization ARHGAP27(DISRUPTS) 28876503; 33557943 2 11 0 +Huwe1 HUWE1 EC 6.3.2.-; EC 6.3.2.19; Ligase; UBIQUITIN LIGASE; Ubiquitin conjugating system; Ubiquitin ligase NP_001395856 501546 rat Y4351-p 13196101 SNTEYHKyQSNSIQI HECT molecular association, regulation transcription, inhibited 7478539 2 0 0 mutation of Y3007 attenuated HUWE1 inhibition of p53-mediated transcription +Stat3 STAT3 DNA-binding; Motility/polarity/chemotaxis; Nuclear receptor co-regulator; Transcription factor P42227 20848 11 D|11 63.82 cM mouse K679-ac 486388 YLYPDIPkEEAFGKY acetylation; phosphorylation transcription, inhibited SIRT1(INDUCES) 19295512 1 1 0 SIRT1 downregulates phosphorylation at STAT3-Y705 and transactivation, deacetylation of STAT3 +NIBAN2 FAM129B Cell adhesion Q96TA1 64855 9q34.11 human Y593-p 25299904 PIDWGEEySNSGGGG molecular association, regulation; phosphorylation carcinogenesis, induced; signaling pathway regulation HRas(INDUCES) 26721396 1 1 4 promotes the dissociation of p120RasGAP from H-Ras; regulates phosphorylation of Ser residues of Meg-3 +Cd5 CD5 Cell surface; Membrane protein, integral P13379 12507 19 A|19 7.16 cM mouse Y452-p 447774 ASHVDNEySQPPRNS molecular association, regulation PIK3R1(NOT_REPORTED) 9079809 6 10 292 +PIP5K1C PIP5K1C Carbohydrate Metabolism - inositol phosphate; EC 2.7.1.68; Kinase, lipid; Motility/polarity/chemotaxis O60331 23396 19p13.3 human K255-ub 125104501 MHLKFDLkGSTYKRR PIP5K protein degradation; ubiquitination 28581524 1 0 0 +TGFBR1 TGFBR1 EC 2.7.11.30; KINASE; Kinase, protein; Membrane protein, integral; Protein kinase, Ser/Thr (receptor); Protein kinase, TKL; Receptor, misc. P36897 7046 9q22.33 human T200-p 4325704 LPLLVQRtIARTIVL TGF_beta_GS molecular association, regulation; phosphorylation; enzymatic activity, induced cell differentiation, induced; signaling pathway regulation FKBP12(DISRUPTS) 23290522; 7774578 2 0 0 TGFBR I-SMAD pathway ; T200V mutation prevented ligand-induced phosphorylation at other residues +E2f8 E2F8 DNA-binding; Transcription factor Q58FA4 108961 7|7 B4 mouse S395-p 10994497 PSFTRHPsLIKLVKS molecular association, regulation cell cycle regulation; apoptosis, inhibited; transcription, induced 14-3-3 zeta(INDUCES) 29363506 1 4 7 +IRS2 IRS2 Adaptor/scaffold; Motility/polarity/chemotaxis Q9Y4H2 8660 13q34 human Y823-p 454963 CGGDSDQyVLMSSPV activity, induced 34731634 1 29 692 +AJUBA JUB Cell adhesion; Motility/polarity/chemotaxis; Transcription, coactivator/corepressor Q96IF1 84962 14q11.2 human S39-p 18011036 GPGKGRLsGLGGPRK autophagy, induced 34706234 1 4 0 induces mitophagy +FBXO4 FBXO4 Ligase; UBIQUITIN LIGASE; Ubiquitin conjugating system; Ubiquitin ligase Q9UKT5 26272 5p13.1 human S12-p 453026 EPRSGTNsPPPPFSD molecular association, regulation; ubiquitination; enzymatic activity, induced FBXO4(INDUCES); 14-3-3 epsilon(INDUCES) 18598945; 21242966 2 37 0 FBX4 dimerization ; promotes cyclin D1 degradation and inhibits oncogenic transformation +NFE2L2 NRF2 DNA-binding; Transcription factor Q16236 4780 2q31.2 human K443-ac 7106325 HRKTPFTkDKHSSRL molecular association, regulation transcription, induced DNA(INDUCES) 19273602 1 1 0 +CCDC106 CCDC106 Q9BWC9 29903 19q13.42 human S130-p 31084482 GGAGGEAsDPESAAS CCDC106 molecular association, regulation; intracellular localization carcinogenesis, induced; cell motility, induced; cell growth, induced; apoptosis, inhibited; signaling pathway regulation p53(INDUCES) 30885251 1 5 0 +NCKIPSD NCKIPSD Adaptor/scaffold; Motility/polarity/chemotaxis; Oncoprotein Q9NZQ3 51517 3p21.31 human T242-p 1868827200 PGSSCSPtPPPVPRR molecular association, regulation RAB5A(INDUCES); GAPVD1(INDUCES) 31358736 1 0 0 +ACE2 ACE2 EC 3.4.17.23; Membrane protein, integral; Protease Q9BYF1 59272 Xp22.2 human S776-p 1880091000 KKKNKARsGENPYAS protein stabilization 35894122 1 1 0 SARS-CoV-2 infection induces GLK overexpression and subsequent ACE2 stabilization +DCBLD2 DCBLD2 Cell adhesion; Membrane protein, integral Q96PD2 131566 3q12.1|3 human Y666-p 478858 GQEVYHAyAEPLPIT molecular association, regulation CRKL(INDUCES) 23770091 2 3 1 +ERBB4 HER4 EC 2.7.10.1; KINASE; Kinase, protein; Membrane protein, integral; Protein kinase, TK; Protein kinase, tyrosine (receptor) Q15303 2066 2q34 human Y1056-p 451500 GHSPPPAyTPMSGNQ activity, induced; molecular association, regulation cell growth, altered PIK3C2A(INDUCES); Arg(INDUCES); PIK3R3(INDUCES); PIK3R2(INDUCES); CBL(INDUCES); PIK3R1(INDUCES) 16729043; 16934755; 18721752; 8617750 3 1 1 critical for HER4 activity to inhibit colony formation +Mapt Tau ACETYLTRANSFERASE; Acetyltransferase; Cytoskeletal P19332 29477 10q32.1 rat S715-p 449082 PVVSGDTsPRHLSNV cytoskeletal reorganization 18245083 145 54 69 +RRAGA RRAGA G protein regulator, misc. Q7L523 10670 9p22.1 human K230-ub 22251391 RDVHRFEkISNIIKQ Gtr1_RagA molecular association, regulation; phosphorylation autophagy, induced; signaling pathway regulation NPRL3(INDUCES); Raptor(DISRUPTS); DEPDC5(INDUCES); NPRL2(INDUCES) 25936802 1 3 0 interaction with GATOR1 complex, regulates mTORC1 signaling, regulates p70S6K phosphorylation +BLNK BLNK Adaptor/scaffold Q8WV28 29760 10q24.1 human Y84-p 449841 EHSDSEMyVMPAEEN molecular association, regulation transcription, altered PLCG1(INDUCES); PLCG2(INDUCES); Btk(INDUCES); NCK2(INDUCES); VAV1(INDUCES) 12456653; 9697839 4 0 0 +Phlpp2 PHLPP2 EC 3.1.3.16; PHOSPHATASE; Protein phosphatase, Ser/Thr (non-receptor); Tumor suppressor Q8BXA7 244650 8|8 D3 mouse S1116-p 17546653 PRPERRCsLHPASSA protein degradation; molecular association, regulation KCTD17(INDUCES) 28859855 1 9 0 +Irs2 IRS2 Adaptor/scaffold; Motility/polarity/chemotaxis F1MAL5 29376 16q12.5 rat S724-p 3217368 GGGYKASsPAESSPE phosphorylation 36207218 9 15 4 inhibits phosphorylation of PI3K, AKT, and eNOS +Ncl NCL DNA-binding; Helicase; Nuclear receptor co-regulator; Nucleolus; RNA-binding P09405 17975 1 C5|1 43.94 cM mouse S34-p 466005 DSEDEEMsEDEDDSS molecular association, regulation carcinogenesis, induced; cell growth, induced; transcription, induced RNA(INDUCES) 37039106 3 42 9 +AURKA AurA EC 2.7.11.1; KINASE; Kinase, protein; Oncoprotein; Protein kinase, Other; Protein kinase, Ser/Thr (non-receptor) O14965 6790 20q13.2 human S51-p 457655 AQRVLCPsNSSQRIP protein stabilization cell cycle regulation; cell growth, induced 17229885; 17895985 3 3 0 dephosphorylation by PPP2CA leads to the protein degradation; transformation +Raf1 RAF1 EC 2.7.11.1; KINASE; Kinase, protein; Oncoprotein; Protein kinase, Ser/Thr (non-receptor); Protein kinase, TKL Q99N57 110157 6 E3|6 53.62 cM mouse S259-p 447741 SQRQRSTsTPNVHMV molecular association, regulation; intracellular localization; enzymatic activity, inhibited cell growth, altered 14-3-3 beta(INDUCES); HRas(DISRUPTS); MEK1(DISRUPTS) 11782426; 11997508; 20212043 58 32 142 +TFAM TFAM DNA-binding; Transcription regulation Q00059 7019 10q21.1 human S61-p 27530800 VSSYLRFsKEQLPIF HMG_box transcription, induced 35278431 2 2 0 +CD44 CD44 Cell adhesion; Membrane protein, integral; Motility/polarity/chemotaxis; Receptor, misc. P16070 960 11p13 human S697-p 465669 AVEDRKPsGLNGEAS cell motility, altered 16785995 1 31 25 critical for chemotaxis +Scnn1b ENaC-beta Channel, sodium; Membrane protein, integral; Membrane protein, multi-pass; Transporter, ion channel P37090 24767 1q36 rat S631-p 2228600 QPLDTMEsDSEVEAI activity, induced; intracellular localization 18308722 1 1 0 membrane expression of ENAC beta and gamma, and may translocate CK2 to the cell membrane.; channel activation +NR4A1 Nur77 Apoptosis; DNA-binding; Nuclear receptor P22736 3164 12q13.13 human S152-p 25692904 SFQPPQLsPWDGSFG protein stabilization 22789442 1 0 0 Pin1 increases stability by acting on CK2 phosphorylated S152 +TNFRSF1A TNF-R1 Membrane protein, integral; Receptor, cytokine P19438 7132 12p13.31 human Y360-p 464365 TDDPATLyAVVENVP Death transcription, induced 21724995 1 0 1 +H3-3A H3F3A DNA-binding P84243 3020 1q42.12 human K9-ac 18545308 RTKQTARkSTGGKAP Histone phosphorylation 16185088 1 6 55 detecting S10 phosphorylation with phospho-antibody was disrupted in dual modified peptides with K9ac and K9 monomethyl as was S28 with K27ac +Lcp2 SLP76 Adaptor/scaffold Q60787 16822 11|11 A4 mouse Y112-p 448218 WSSFEDDyESPNDDD molecular association, regulation; phosphorylation cell differentiation, altered; apoptosis, altered; cytoskeletal reorganization; cell adhesion, altered; transcription, induced; signaling pathway regulation; transcription, altered VAV1(INDUCES) 11313406; 12640123; 16456002; 18342008; 18663126; 22291096; 9047237 17 0 0 mutation of this site impairs thrombus formation; required for intergrin activation +Rarg RARG iso2 DNA-binding; Nuclear receptor P18911-2 19411 15 F3|15 57.4 cM mouse S360-p 62884000 YARRRRPsQPYMFPR Hormone_recep activity, induced 31740618 2 0 0 +Yap1 YAP1 Oncoprotein; Transcription, coactivator/corepressor P46938 22601 9|9 A1 mouse S94-p 452305 KSHSRQAsTDAGTAG intracellular localization transcription, inhibited; signaling pathway regulation 33046882; 34133792 23 63 341 +Cd4 CD4 Cell surface; Membrane protein, integral P06332 12504 6 F2|6 59.17 cM mouse S432-p 451188 QRQAARMsQIKRLLS Tcell_CD4_C intracellular localization 19050241 3 0 3 +Ccnt1 CCNT1 Cell cycle regulation; Transcription initiation complex Q9QWV9 12455 15|15 F1 mouse K404-ac 9263557 AEELAAQkRQLENME molecular association, regulation; enzymatic activity, induced transcription, induced BCDIN3(DISRUPTS); HEXIM1(DISRUPTS) 19387490 2 1 2 enhances CDK9/cyclin T1 transcriptional activity, disrupting HEXIM1 and BCDIN3 association +BRCA1 BRCA1 EC 6.3.2.-; Nuclear receptor co-regulator; Transcription, coactivator/corepressor; Tumor suppressor; UBIQUITIN LIGASE; Ubiquitin conjugating system; Ubiquitin ligase P38398 672 17q21.31 human S1542-p 450009 EEQQLEEsGPHDLTE molecular association, regulation ATM(INDUCES) 10550055 1 9 0 +Crem CREM DNA-binding; Transcription factor P27699 12916 18|18 A1 mouse S133-p 448412 EILSRRPsYRKILNE pKID activity, induced; activity, inhibited transcription, induced; transcription, altered 17526487; 7923380; 8114763; 8404858 6 2 40 +SNIP1 SNIP1 Inhibitor Q8TAD8 79753 1p34.3 human K108-sm 55438617 HHSTVKVkQEREDHP molecular association, regulation cell motility, induced; transcription, induced 27703003 1 1 0 SUMOylation decreases the inhibitory effect of SNIP1 on TGF-beta-induced formation of the Smad2/4 and Smad3/4 complexes +SP100 SP100 DNA-binding; Transcription, coactivator/corepressor P23497 6672 2q37.1 human K297-sm 2793911 SVRLVDIkKEKPFSN protein degradation; molecular association, regulation chromatin organization, altered HP1 alpha(INDUCES) 11313457; 23485562 6 4 0 +Ap2m1 AP2M1 Adaptor/scaffold; Vesicle P84092 116563 11q23 rat S45-p 2048345 HARQQVRsPVTNIAR Clat_adaptor_s molecular association, regulation signaling pathway regulation TRPV1(DISRUPTS) 31186372 1 6 0 +KLF1 KLF1 C2H2-type zinc finger protein; DNA-binding; Transcription factor Q13351 10661 19p13.13 human K288-ac 461016 CAHPGCGkSYTKSSH zf-C2H2 acetylation; molecular association, regulation chromatin organization, altered; transcription, induced DNA(INDUCES) 11259590; 18710946 3 0 0 induces H3 acetylation; acetylation increased ability to interact with SWI-SNF complex +BCAR3 BCAR3 Adaptor/scaffold; GEF; GEF, Ras; Motility/polarity/chemotaxis O75815 8412 1p22.1 human Y117-p 454975 LLDPTVEyVKFSKER protein degradation; molecular association, regulation; ubiquitination; phosphorylation cell motility, induced SOCS6(INDUCES) 34169835 1 10 115 induces Cas phosphorylation +PPP1R2 PPP1R2 Inhibitor; Motility/polarity/chemotaxis; Protein phosphatase, regulatory subunit P41236 5504 3q29 human S122-p 449053 RIQEQESsGEEDSDL IPP-2 intracellular localization 9405437 3 74 29 Phosphorylation is required for nuclear localization during S phase. +SMN1 SMN RNA processing; RNA-binding Q16637 6606 5q13.2 human S63-p 33586274 NGDICETsGKPKTTP SMN molecular association, regulation; protein conformation cell growth, induced SMN(INDUCES) 34161763 1 2 0 +Lrrk2 LRRK2 EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, Ser/Thr (non-receptor); Protein kinase, TKL Q5S006 66725 15|15 E3 mouse S910-p 4725893 LVKRKSNsISVGEVY molecular association, regulation; enzymatic activity, inhibited autophagy, induced 14-3-3 beta(INDUCES); 14-3-3 theta(INDUCES); 14-3-3 zeta(INDUCES); 14-3-3 epsilon(INDUCES); 14-3-3 eta(INDUCES) 20642453; 20659021; 37454104 22 17 0 +IL24 IL24 Motility/polarity/chemotaxis; Secreted; Secreted, signal peptide Q13007 11009 1q32.1 human S101-p 41122604 QEVLQNVsDAESCYL activity, induced; intracellular localization cell cycle regulation; carcinogenesis, inhibited; cell growth, inhibited; cell motility, inhibited; signaling pathway regulation 26009991 1 0 0 IL24 maturation and secretion; activates Caspase-9, PARP, and JNK; inhibits the AKT signaling pathway +MARK3 MARK3 iso3 EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, CAMK; Protein kinase, Ser/Thr (non-receptor) P27448-3 4140 14q32.32-q32.33 human T90-p 3597303 AIKIIDKtQLNPTSL Pkinase enzymatic activity, inhibited 15319445 1 0 0 +TP53 p53 Activator; DNA-binding; Motility/polarity/chemotaxis; Nuclear receptor co-regulator; Transcription factor; Tumor suppressor P04637 7157 17p13.1 human K291-ub 9381803 TEEENLRkKGEPHHE protein degradation cell cycle regulation; cell growth, induced; apoptosis, inhibited 19536131; 33568778 2 0 0 +Suds3 SDS3 Helicase Q8BR65 71954 5|5 F mouse S228-p 454398 RTLNKLKsPKRPASP Sds3 activity, induced; acetylation apoptosis, induced; transcription, altered; cell growth, altered 15489224; 22398430 2 4 3 induce HDAC1 activity +Twist1 TWIST1 Cell development/differentiation; DNA-binding; Inhibitor; Transcription regulation P26687 22160 12 A3|12 14.81 cM mouse Y107-p 10943328 GGGSPQSyEELQTQR molecular association, regulation G3BP-2(DISRUPTS) 25893917 2 2 0 matrix stiffness +HMGB1 HMGB1 DNA repair, damage; Nuclear receptor co-regulator P09429 3146 13q12.3 human S53-p 25604400 SERWKTMsAKEKGKF HMG_box_2 intracellular localization 22750245 1 3 0 +CAMKK2 CAMKK2 Autophagy; EC 2.7.11.17; KINASE; Kinase, protein; Protein kinase, Other; Protein kinase, Ser/Thr (non-receptor) Q96RR4 10645 12q24.31 human T85-p 31873289 GQEVPLDtSGSQARP phosphorylation; enzymatic activity, induced signaling pathway regulation 26395653; 32216002 2 2 0 autonomous activity in the presence of EGTA was lost in a CaMKK2 T85A mutant, molecular memory; induces phosphorylation of substrate AMPK, thus inducing CAMKK2 signaling +EGLN1 EGLN1 EC 1.14.11.29; Oxidoreductase Q9GZT9 54583 1q42.2 human T405-p 15409614 RAKVKYLtGEKGVRV molecular association, regulation; protein conformation HIF1A(INDUCES) 36902141 1 0 1 +VGLL1 VGLL1 Transcription, coactivator/corepressor Q99990 51442 Xq26.3 human S84-p 1870773106 PNQWRYSsPWTKPQP molecular association, regulation carcinogenesis, induced; cell growth, induced; transcription, induced TEAD4(INDUCES) 33069758 1 0 0 +ADGRE5 CD97 GPCR, family 2; Membrane protein, integral; Membrane protein, multi-pass; Receptor, GPCR P48960 976 19p13.12 human S833-p 3190861 RALRASEsGI_____ molecular association, regulation; intracellular localization cytoskeletal reorganization; signaling pathway regulation; cell adhesion, inhibited DLG1(DISRUPTS) 30134161 1 11 0 +Ripk3 RIPK3 EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, Ser/Thr (non-receptor); Protein kinase, TKL Q9QZL0 56532 14|14 C3 mouse S165-p 27928503 KLADFGLsTFQGGSQ Pkinase molecular association, regulation; enzymatic activity, inhibited; phosphorylation apoptosis, induced; signaling pathway regulation RIPK1(INDUCES); FADD(INDUCES); CASP8(INDUCES) 34029184 3 2 0 inhibits phosphorylation of RIPK3-S227, induces RIPK1/FADD/caspase-8 pathway +KEAP1 KEAP1 Endoplasmic reticulum; Motility/polarity/chemotaxis; Transcription regulation; UBIQUITIN LIGASE; Ubiquitin conjugating system Q14145 9817 19p13.2 human K108-ub 12344574 ASSSPVFkAMFTNGL BTB protein degradation 36163178 1 2 5 +CBL CBL Adaptor/scaffold; EC 6.3.2.-; EC 6.3.2.19; Ligase; Motility/polarity/chemotaxis; Oncoprotein; UBIQUITIN LIGASE; Ubiquitin conjugating system; Ubiquitin ligase P22681 867 11q23.3 human Y700-p 448529 EGEEDTEyMTPSSRP protein degradation; molecular association, regulation; enzymatic activity, induced cell growth, induced; cell motility, altered; signaling pathway regulation; cell growth, altered Src(INDUCES); CRKL(INDUCES); CRK(INDUCES); PIK3CA(INDUCES); VAV1(INDUCES) 11997497; 12604776; 12881521; 15922744; 21967979; 33512474; 9988765 16 19 493 The double mutant Y700/774F was used in this study; induces cytokine signaling; integrin-mediated platelet outside-in signaling leading to platelet spreading; Src induces Cbl phosphorylation inducing Cbl degredation and alters EGFR desensitization. +MAPRE1 EB1 Cytoskeletal; Motility/polarity/chemotaxis Q15691 22919 20q11.21 human T166-p 476323 APQRPIStQRTAAAP intracellular localization carcinogenesis, inhibited; cell growth, inhibited; apoptosis, induced; cytoskeletal reorganization; cell motility, inhibited 24930764 1 2 2 increased microtubule growth rate in T166A mutant; Increased sensitivity to microtubulr targeting agents +Gab2 GAB2 Adaptor/scaffold Q9Z1S8 14389 7|7 E1 mouse Y603-p 449788 KSTGSVDyLALDFQP molecular association, regulation cell differentiation, altered; cell growth, altered SHP-2(INDUCES) 11287610 6 8 55 +PLEKHG2 PLEKHG2 GEF; GEF, misc.; Tumor suppressor Q9H7P9 64857 19q13.2 human Y489-p 23133014 SEPVKDPyVMFPQNA molecular association, regulation Arg(INDUCES); Abl(INDUCES); PIK3R3(INDUCES); PIK3R1(INDUCES) 24378532 1 1 2 +FOXM1 FOXM1 DNA-binding; Transcription factor Q08050 2305 12p13.33 human K495-sm 31898507 PSPAPSFkEESSHSW protein degradation; ubiquitination; intracellular localization cell cycle regulation; cell growth, inhibited; transcription, inhibited 24362530 2 0 0 +KIT Kit EC 2.7.10.1; KINASE; Kinase, protein; Membrane protein, integral; Oncoprotein; Protein kinase, TK; Protein kinase, tyrosine (receptor) P10721 3815 4q12 human Y900-p 450042 EHAPAEMyDIMKTCW PK_Tyr_Ser-Thr protein stabilization; molecular association, regulation PIK3C2A(INDUCES); CRK(INDUCES) 12878163 1 0 2 +HES6 HES6 Transcription, coactivator/corepressor Q96HZ4 55502 2q37.3 human S183-p 455670 GPGDDLCsDLEEAPE cell cycle regulation 12972610 1 0 0 +JUN Jun Oncoprotein; Transcription factor P05412 3725 1p32.1 human S63-p 447686 KNSDLLTsPDVGLLK Jun activity, induced; acetylation; protein stabilization; molecular association, regulation; enzymatic activity, induced cell cycle regulation; carcinogenesis, induced; apoptosis, altered; carcinogenesis, inhibited; cell motility, induced; apoptosis, induced; transcription, induced; transcription, altered; cell growth, induced; transcription, inhibited; cell growth, altered TCF4(INDUCES); HDAC3(DISRUPTS); JNK1(DISRUPTS); MBD3(DISRUPTS); PIN1(INDUCES); NFkB-p65(INDUCES) DNA(INDUCES); DNA(DISRUPTS) 11313929; 11401472; 11432833; 11739718; 12040039; 12853483; 14617628; 1496019; 15378002; 18443042; 18794113; 19118012; 1922387; 20395206; 21697492; 23720779; 26745678; 26755651; 33822843; 34408980; 34764490; 34785213; 35000271; 35263587; 36253406; 36483740; 37020040; 37261387; 7737130; 7744008; 8072547; 8224842 133 43 4 +Foxo1 FOXO1A DNA-binding; Nuclear receptor co-regulator; Oncoprotein; Transcription factor Q9R1E0 56458 3 C|3 23.19 cM mouse S467-p 478371 KELLTSDsPPHNDIM FOXO_KIX_bdg molecular association, regulation; intracellular localization transcription, inhibited DUSP6(INDUCES) 22503562; 22848439 3 11 0 +ARRB2 ARRB2 Adaptor/scaffold P32121 409 17p13.2 human K295-sm 25350103 LALDGKLkHEDTNLA Arrestin_C molecular association, regulation; ubiquitination transcription, induced; signaling pathway regulation TRAF6(DISRUPTS) 25425640 2 0 0 enhances TRAF6 oligomerization, regulation of TRAF6 signaling +Pde3a PDE3A EC 3.1.4.17; Membrane protein, integral; Membrane protein, multi-pass; Nucleotide Metabolism - purine; Phosphodiesterase Q9Z0X4 54611 6|6 G2 mouse S291-p 471416 WKRRRRSsSVVAGEM enzymatic activity, induced 17124499 2 2 9 activated during oocytes maturation in mouse treated with hCG ; required for insulin-dependent Xenopus oocyte maturation +HES1 HES1 Cell development/differentiation; Motility/polarity/chemotaxis; Transcription factor Q14469 3280 3q29 human K109-ub 22245544 TDPSVLGkYRAGFSE Hairy_orange protein degradation cell differentiation, induced 29070679 1 2 0 +Mpc2 MPC2 Membrane protein, multi-pass; Mitochondrial Q9D023 70456 1|1 H2.2 mouse K26-ac 1195924 KVELLLPkKLRPLYN protein degradation; activity, inhibited 28154187 1 2 6 inhibits pyruvate transport activity +Ulk1 ULK1 Autophagy; EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, Other; Protein kinase, Ser/Thr (non-receptor) O70405 22241 5|5 F mouse S637-p 3176158 FDFPKTPsSQNLLTL cell cycle regulation; autophagy, induced; cell growth, induced; autophagy, altered 21205641; 32516310 4 35 41 +INTS11 INTS11 EC 3.1.27.-; RNA processing; Ribonuclease Q5TA45 54973 1p36.33 human K475-sm 1883375206 GLLPEAKkPRLLHGT molecular association, regulation; intracellular localization 36454007 1 0 0 regulates Integrator subcellular localization and interaction with integrator subunits +Braf BRAF iso1 EC 2.7.11.1; KINASE; Kinase, protein; Oncoprotein; Protein kinase, Ser/Thr (non-receptor); Protein kinase, TKL P28028-1 109880 6 B1|6 18.43 cM mouse S766-p 450242 PKIHRSAsEPSLNRA molecular association, regulation cell cycle regulation; cell growth, inhibited 14-3-3 beta(INDUCES); KSR(INDUCES) 24095280 8 59 25 +CDC37 CDC37 Chaperone Q16543 11140 19p13.2 human S97-p 1214257700 QLRKEERsWEQKLEE CDC37_N protein stabilization; molecular association, regulation HSP90A(INDUCES) 30068645 1 1 0 inhibits ubiquitination and degradation of AXL +GNAI1 G-alpha i1 G protein; G protein, heterotrimeric; G protein, heterotrimeric alpha G((i/o/t/z)) P63096 2770 7q21.11 human Y154-p 1871177702 QLNDSAAyYLNDLDR G-alpha enzymatic activity, induced carcinogenesis, induced; signaling pathway regulation 33139573 1 1 0 +Cry2 CRY2 DNA-binding; Lyase Q9R194 12953 2|2 E1 mouse K347-ub 27717314 RNPEALAkWAEGKTG FAD_binding_7 protein degradation; intracellular localization 23452856 1 1 0 +JUN Jun Oncoprotein; Transcription factor P05412 3725 1p32.1 human K268-ac 458866 RNRIAASkCRKRKLE bZIP_1 molecular association, regulation carcinogenesis, induced; transcription, induced; signaling pathway regulation DNA(INDUCES) 16214953; 27956703 3 0 0 AP-1 signaling pathway +Kcnd2 Kv4.2 Channel, potassium; Membrane protein, integral; Membrane protein, multi-pass Q63881 rat S447-p 4668101 SANAYMQsKRNGLLS intracellular localization; phosphorylation 18795890 1 0 1 increases phosphorylation at T602 and T607 by ERK +PPIP5K2 PPIP5K2 EC 2.7.4.21; EC 2.7.4.24; Kinase, lipid O43314 23262 5q21.1 human S1006-p 3175115 TGRRRRRsGEQITSS molecular association, regulation; intracellular localization carcinogenesis, inhibited; DNA repair, inhibited 14-3-3 gamma(INDUCES) 26084399; 34645979 2 40 46 +CDC6 CDC6 Cell cycle regulation Q99741 990 17q21.2 human S54-p 450914 RVKALPLsPRKRLGD protein stabilization; molecular association, regulation; intracellular localization cell cycle regulation CDH1(DISRUPTS) 10339564; 14749377; 16153703; 22179839; 23129444; 24216307; 9889196 10 15 0 +Runx2 AML3 DNA-binding; Transcription factor Q08775 12393 17 B3|17 21.33 cM mouse S380-p 10892804 DPRQAQSsPPWSYDQ protein stabilization; acetylation transcription, altered 20007706 10 2 0 stimulates AML3 acetylation +CD300LF IREM-1 Immunoglobulin superfamily; Membrane protein, integral; Receptor, misc. Q8TDQ1 146722 17q25.1 human S216-p 51635626 TLQLAGTsPQKATTK SIT signaling pathway regulation 32152116 1 1 0 +IRF7 IRF7 DNA-binding; Transcription factor Q92985 3665 11p15.5 human S472-p 1276103 TQREGVSsLDSSSLS transcription, inhibited 10893229 3 0 0 +MCL1 MCL1 Apoptosis; Channel, misc.; Inhibitor; Membrane protein, integral; Mitochondrial Q07820 4170 1q21.2 human T163-p 455375 TDGSLPStPPPAEEE protein degradation; protein stabilization; molecular association, regulation; ubiquitination cell cycle regulation; carcinogenesis, induced; carcinogenesis, inhibited; cell growth, induced; apoptosis, induced; apoptosis, inhibited; cell growth, altered BAK1(INDUCES); FBXW7(INDUCES); BIM(INDUCES); USP9X(INDUCES); NOXA(INDUCES); PIN1(INDUCES) 12223490; 18676833; 21368833; 21368834; 25915848; 26205817; 26219338; 27738316; 28301598; 33658484; 34758305; 36346691; 36455198 20 17 8 +Mdm4 MDM4 EC 6.3.2.-; Ligase; UBIQUITIN LIGASE; Ubiquitin conjugating system; Ubiquitin ligase O35618 17248 1 E4|1 57.75 cM mouse S402-p 474540 DLAHSSEsQEIISSA protein degradation; molecular association, regulation cell cycle regulation 14-3-3 gamma(INDUCES) 19808970; 24190973 13 2 0 +MAPK6 ERK3 EC 2.7.11.24; KINASE; Kinase, protein; Protein kinase, CMGC; Protein kinase, Ser/Thr (non-receptor) Q16659 5597 15q21.2 human S189-p 448267 YSHKGHLsEGLVTKW Pkinase molecular association, regulation; intracellular localization MAPKAPK5(INDUCES) 21317288 5 34 2 +IRS1 IRS1 Adaptor/scaffold; Motility/polarity/chemotaxis P35568 3667 2q36.3 human S639-p 447507 YMPMSPKsVSAPQQI intracellular localization 16914728 35 4 0 via cell fractionation experiments +ABL1 Abl EC 2.7.10.2; KINASE; Kinase, protein; Oncoprotein; Protein kinase, TK; Protein kinase, tyrosine (non-receptor) P00519 25 9q34.12 human Y312-p 4922741 CTREPPFyIITEFMT PK_Tyr_Ser-Thr enzymatic activity, induced 18775312 1 0 0 SH2 and catalytic domains of Fes and Abl interact with ligand, stimulating kinase activity. +CREB3L3 CREB3L3 Membrane protein, integral; Transcription factor Q68CJ9 84699 19p13.3 human S395-p 1880714004 ADTTREEsPGSPGAD exocytosis, induced 36649378 1 0 0 +FCHSD2 FCHSD2 Adaptor/scaffold O94868 9873 11q13.4 human S681-p 454693 SSLYFPRsPSANEKS intracellular localization endocytosis, induced; carcinogenesis, inhibited; cell growth, inhibited; cell motility, inhibited; signaling pathway regulation 30249660 1 15 106 EGFR/Ras/ERK1/2 pathway +MAZ MAZ C2H2-type zinc finger protein; RNA-binding; Transcription factor P56270 4150 16p11.2 human S460-p 465574 PTAVGSLsGAEGVPV transcription, induced Myc(NOT_REPORTED) 10448092 1 0 0 regulates DNA binding of MAZ to c-myc promoter element +DPF3 DPF3 iso2 C2H2-type zinc finger protein Q92784-2 8110 14q24.2 human S348-p 23251120 GRRSGRGsPTADKKG molecular association, regulation transcription, induced HEY1(INDUCES) 26582913 1 3 1 DPF3a initiates transcription of fetal genes and promotes pathological cardiac hypertrophy. +Pitpnb PITPNB Lipid-binding P53812 114561 12q16 rat S262-p 451299 ETMRKKGsVRGTSAA not reported 16540520; 16780419 5 17 22 S261 phosphorylation does not affect PITPNB localization to Golgi.; isoform containing S261 transfers sphingomyelin more efficiently; does not have an influence on the localization of PITPNB to Golgi membranes +ARHGEF7 ARHGEF7 GEF; GEF, Rac/Rho; Motility/polarity/chemotaxis Q14155 8874 13q34 human S703-p 455681 EEFASRKsTAALEED RhoGEF67_u2 activity, induced; molecular association, regulation cytoskeletal reorganization RAP1GDS1(DISRUPTS) 16954223 3 19 2 activates ARHGEF7's exchange activity on Rac1 +H2BC3 H2B DNA-binding P33778 3018 6p22.2 human K120-ac 3612295 EGTKAVTkYTSSK__ molecular association, regulation polybromo 1(INDUCES) 20368734 3 10 27 varying site specificity binding for each bromodomain 1-6 +MAP3K5 ASK1 EC 2.7.11.25; KINASE; Kinase, protein; Protein kinase, STE; Protein kinase, Ser/Thr (non-receptor) Q99683 4217 6q23.3 human T1326-p 27928509 VNGADEDtISRFLAE enzymatic activity, inhibited carcinogenesis, induced 23608533 1 1 0 +STK3 MST2 Autophagy; EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, STE; Protein kinase, Ser/Thr (non-receptor) Q13188 6788 8q22.2 human T180-p 448899 DTMAKRNtVIGTPFW Pkinase molecular association, regulation; protein processing; phosphorylation; enzymatic activity, induced cell cycle regulation; apoptosis, altered; carcinogenesis, inhibited; cell growth, inhibited; apoptosis, induced; signaling pathway regulation LATS1(INDUCES) 20086174; 20231902; 22389451; 24362629; 36622276; 37319316 15 0 5 +NR3C1 GR DNA-binding; Mitochondrial; Nuclear receptor; Transcription factor P04150 2908 5q31.3 human T635-p 1872513505 IINEQRMtLPCMYDQ Hormone_recep molecular association, regulation 14-3-3 zeta(INDUCES) 33744286 1 1 0 +Pdzrn3 PDZRN3 EC 6.3.2.-; Ligase; UBIQUITIN LIGASE; Ubiquitin conjugating system; Ubiquitin ligase Q69ZS0 55983 6|6 D3 mouse S962-p 23130749 TTDDDAMsEMKMGRY protein degradation cell motility, inhibited 34135125 1 2 3 +Mcm2 MCM2 DNA-binding; EC 3.6.4.12 P97310 17216 6|6 D1 mouse S27-p 452310 ISDPLTSsPGRSSRR cell cycle regulation 35508654 4 97 63 +PARK7 DJ-1 EC 3.4.-.-; Nuclear receptor co-regulator; Transcription regulation; Tumor suppressor Q99497 11315 1p36.23 human T125-p 1869992402 GFGSKVTtHPLAKDK DJ-1_PfpI protein degradation; protein conformation; enzymatic activity, induced 32858971 1 1 0 +SLC9A3R1 NHERF Adaptor/scaffold; Motility/polarity/chemotaxis E2RGF3 dog S348-p 455752 ERAHQKRsSKRAPQM EBP50_C molecular association, regulation; intracellular localization; enzymatic activity, inhibited Ezrin(DISRUPTS); ARHGEF7(DISRUPTS) 22301917 5 1 18 Rac1 activity inhibited +APEX1 APE1 DNA repair, damage; DNA-binding; Deoxyribonuclease; EC 4.2.99.18; Endoplasmic reticulum; Hydrolase; Lyase; Nuclear receptor co-regulator; Nucleolus; Transcription, coactivator/corepressor P27695 328 14q11.2 human K24-ub 6423508 LRTEPEAkKSKTAAK protein degradation; enzymatic activity, altered 19219073 1 1 0 +SEPTIN9 SEPT9 iso2 Cell cycle regulation; Cytoskeletal; Hydrolase Q9UHD8-2 10801 17q25.3 human T24-p 469506 EVETPNStPPRRVQT molecular association, regulation cell cycle regulation PIN1(INDUCES) 23990466 1 17 53 +CALCA CALCA Secreted; Secreted, signal peptide P01258 796 11p15.2 human S89-p 1871177714 SKRCGNLsTCMLGTY Calc_CGRP_IAPP protein conformation 33220304 0 1 0 regulation of peptide fibrillation +Myd88 MYD88 Adaptor/scaffold P22366 17874 9 F3|9 71.33 cM mouse Y257-p 474538 KRLIPIKyKAMKKDF TIR molecular association, regulation cell growth, altered PIK3R1(INDUCES) 17055754 4 0 0 required for Akt activation by CpG DNA +Braf BRAF iso1 EC 2.7.11.1; KINASE; Kinase, protein; Oncoprotein; Protein kinase, Ser/Thr (non-receptor); Protein kinase, TKL P28028-1 109880 6 B1|6 18.43 cM mouse T636-p 447807 IGDFGLAtVKSRWSG PK_Tyr_Ser-Thr activity, induced; phosphorylation carcinogenesis, induced; signaling pathway regulation 30659267 12 0 0 phosphorylation of MEK/ERK and its signaling +Trpc6 TRPC6 Channel, cation; Membrane protein, integral; Membrane protein, multi-pass Q99N78 89823 8q11 rat T69-p 470868 RLTHRRQtVLREKGR activity, inhibited 21799177 11 2 6 suppressed Agn-II induced calcium influx +PNPLA8 PNPLA8 EC 3.1.1.5; Membrane protein, integral; Motility/polarity/chemotaxis; Phospholipase Q9NP80 50640 7q31.1 human S515-p 18638842 KLGSDVFsQNVIVGT Patatin activity, induced; enzymatic activity, induced transcription, induced; signaling pathway regulation 23258543; 25492867 2 1 0 Increase PGE2 release and leads to conformational change in the enzyme; ATF6 activation +DDX39A DDX39 EC 3.6.4.13; Helicase; RNA splicing; RNA-binding O00148 10212 19p13.12 human K155-sm 1876998411 FGGLSIKkDEEVLKK DEAD molecular association, regulation RNA(DISRUPTS) 32393512 1 1 0 +CTNND1 CTNND1 Actin-binding; Adaptor/scaffold; Cell adhesion; G protein regulator, misc.; Motility/polarity/chemotaxis O60716 1500 11q12.1 human Y228-p 449648 YPGGSDNyGSLSRVT intracellular localization cell adhesion, induced 25386896; 26302406 8 45 1087 +MAFG MAFG Cell cycle regulation; DNA-binding O15525 4097 17q25.3 human S124-p 18011934 FARTVARsPVAPARG protein stabilization transcription, inhibited 25219500; 26787892 2 10 1 +UHRF1 UHRF1 DNA-binding; EC 6.3.2.-; EC 6.3.2.19; Ligase; Transcription factor; UBIQUITIN LIGASE; Ubiquitin conjugating system; Ubiquitin ligase Q96T88 29128 19p13.3 human K650-ac 1883407605 GKGKWKRkSAGGGPS cell cycle regulation; cell growth, induced 35951156 1 0 0 +IL6R IL6R Membrane protein, integral; Receptor, cytokine P08887 3570 1q21.3 human K401-ub 1881380904 LRALKEGkTSMHPPY receptor internalization, induced; protein degradation transcription, inhibited 34785732 1 0 0 In IL6R K401R and gp130 K849R mutants, IL-6-induced transcription of downstream genes compared to wild-type receptors. +Pi4k2a PI4K2A EC 2.7.1.67; Kinase, lipid; Motility/polarity/chemotaxis Q2TBE6 84095 19 C3|19 35.74 cM mouse S51-p 468435 SGPSPPCsPGHDRER phosphorylation 25083612 2 68 7 +SMAD1 SMAD1 DNA-binding; Transcription factor Q15797 4086 4q31.21 human K269-ub 1051004 AVAYEEPkHWCSIVY MH2 protein degradation 17963781 1 1 0 +SNAP25 SNAP-25 Vesicle P60880 6616 20p12.2 human S28-p 23939100 LADESLEsTRRMLQL exocytosis, induced 22311984 2 2 0 +ASAP3 DDEFL1 GAP; GAP, ARF; Motility/polarity/chemotaxis Q8TDY4 55616 1p36.12 human Y733-p 462087 LDISNKTyETVASLG molecular association, regulation endocytosis, induced; cell motility, inhibited GRB2(INDUCES) 22027826 1 4 10 promotes recycling of ITGB1, inhibits cell spreading +ATR ATR EC 2.7.11.1; KINASE; Kinase, protein; Membrane protein, integral; Protein kinase, Ser/Thr (non-receptor); Protein kinase, atypical Q13535 545 3q23 human S1333-p 34425600 ETVEPIIsQLVTVLL enzymatic activity, induced cell cycle regulation 24901225 1 0 0 S1333 A or D mutant, no noticeable checkpoint or replication defects +BCL3 Bcl-3 Apoptosis; Nuclear receptor co-regulator; Oncoprotein; Transcription regulation P20749 602 19q13.32 human S41-p 27444668 KRPLRAPsPEPAAPR protein stabilization; ubiquitination; intracellular localization transcription, induced 28689659 1 13 0 nuclear localization +PSME3 PSME3 Nuclear receptor co-regulator; Protease; Proteasome complex P61289 10197 17q21.31 human K12-sm 25344503 LKVDQEVkLKVDSFR PA28_alpha protein stabilization; intracellular localization; enzymatic activity, induced 21445096 1 0 0 +RPRM RPRM Membrane protein, integral Q9NS64 56475 2q23.3 human S98-p 15722493 LVKDRRPsKEVEAVV protein degradation; molecular association, regulation; intracellular localization IPO11(DISRUPTS) 36185355 1 5 0 +Yap1 YAP1 Oncoprotein; Transcription, coactivator/corepressor P46938 22601 9|9 A1 mouse S113-p 485035 QHVRAHSsPASLQLG activity, induced cell differentiation, induced; transcription, induced 36640330 8 12 77 +TCEAL1 SIIR iso2 Transcription initiation complex AAA60149 9338 Xq22.2 human S36-p 451217 PKSSPPRsSLRRSSP BEX transcription, altered 7592688 1 0 0 S36A/S37A mutation resulted in a substantial loss of LTR repression function suggesting that RSV LTR repression may be regulated by S36 and/or S37 phosphorylation. +TBC1D4 AS160 GAP; GAP, Rab O60343 9882 13q22.2 human S588-p 455920 RMRGRLGsVDSFERS molecular association, regulation endocytosis, induced; signaling pathway regulation 14-3-3 epsilon(INDUCES) 20410134; 26465605; 35810470 21 68 253 regulates insulin signaling; albumin endocytosis; multiple sites (6P) mutant +PRKN PARK2 EC 6.3.2.-; EC 6.3.2.19; Ligase; Translation; Translation regulation; UBIQUITIN LIGASE; Ubiquitin conjugating system; Ubiquitin ligase O60260 5071 6q26 human S131-p 454421 HTDSRKDsPPAGSPA intracellular localization; enzymatic activity, inhibited apoptosis, induced 17327227; 34990728 5 3 0 +STK11 LKB1 Autophagy; EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, CAMK; Protein kinase, Ser/Thr (non-receptor); Tumor suppressor Q15831 6794 19p13.3 human K48-ac 3173806 KRAKLIGkYLMGDLL molecular association, regulation; intracellular localization; enzymatic activity, inhibited; phosphorylation STRAD(DISRUPTS) 18687677 2 1 0 reduces LKB1 phosphorylation at Ser-428 and Thr-336 +MDM2 MDM2 EC 6.3.2.-; EC 6.3.2.19; Inhibitor; Ligase; NEDDYLATION LIGASE; Neddylation Ligase; Nucleolus; Oncoprotein; UBIQUITIN LIGASE; Ubiquitin conjugating system; Ubiquitin ligase Q00987 4193 12q15 human S118-p 15714603 NQQESSDsGTSVSEN protein degradation; molecular association, regulation; ubiquitination FBW1B(INDUCES) 20708156 2 0 0 +Insr INSR EC 2.7.10.1; KINASE; Kinase, protein; Membrane protein, integral; Protein kinase, TK; Protein kinase, tyrosine (receptor) P15208 16337 8 A1.1|8 1.82 cM mouse Y989-p 447685 YASSNPEyLSASDVF molecular association, regulation cell differentiation, induced IRS2(INDUCES); IRS1(INDUCES) 34694913; 35074429 25 0 0 +Tssk4 TSSK4 EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, CAMK; Protein kinase, Ser/Thr (non-receptor) Q9D411 71099 14|14 C3 mouse T197-p 27138201 SLSHLSQtYCGSFAY Pkinase enzymatic activity, induced 23054012 1 0 0 +Cdk16 CDK16 Cell cycle regulation; EC 2.7.11.22; KINASE; Kinase, protein; Motility/polarity/chemotaxis; Protein kinase, CMGC; Protein kinase, Ser/Thr (non-receptor) Q04735 18555 X A1.3|X 16.18 cM mouse S95-p 453454 TSSDEVQsPVRVRMR cell differentiation, induced 21335063 2 22 2 dendritic development +MAPKAPK5 MAPKAPK5 EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, CAMK; Protein kinase, Ser/Thr (non-receptor); Tumor suppressor Q8IW41 8550 12q24.12-q24.13 human S354-p 27452609 VSLKPLHsVNNPILR enzymatic activity, induced carcinogenesis, induced; cell motility, induced 35064619 1 10 1 +Dtna DTNA Motility/polarity/chemotaxis Q9D2N4 13527 18 A2|18 12.08 cM mouse Y730-p 1869344403 NELQLEEyLKQKLQD protein stabilization; molecular association, regulation KAP(INDUCES) 32532815 1 0 0 +Jak2 JAK2 EC 2.7.10.2; KINASE; Kinase, protein; Oncoprotein; Protein kinase, TK; Protein kinase, tyrosine (non-receptor) Q62120 16452 19 C1|19 23.73 cM mouse Y1007-p 448407 VLPQDKEyYKVKEPG PK_Tyr_Ser-Thr protein degradation; ubiquitination; enzymatic activity, induced cell growth, induced; signaling pathway regulation SOCS1(INDUCES) 11971965; 16705159; 16705160; 18160720; 20304997; 21685897; 24526685; 24614172; 30573679; 36356831; 9111318 80 5 15 cytokine signaling pathway +Zc3hav1 ZAP RNA-binding; Transferase Q8K3Y6 252832 4q22 rat S266-p 4776621 EFLSPVVsPLGSGPP activity, induced 22514281 1 8 0 +MRE11 MRE11A Cell cycle regulation; DNA repair, damage; DNA-binding; Deoxyribonuclease P49959 4361 11q21 human S561-p 23127159 MANDSDDsISAATNK protein stabilization; molecular association, regulation PIH1D1(INDUCES) 28436950 1 0 2 +CCNF CCNF Cell cycle regulation P41002 899 16p13.3 human T31-p 234613504 RRRPRNLtILSLPED protein stabilization cell cycle regulation 28954236 1 1 0 cell-cycle progression +NTRK3 TrkC EC 2.7.10.1; KINASE; Kinase, protein; Membrane protein, integral; Protein kinase, TK; Protein kinase, tyrosine (receptor) Q16288 4916 15q25.3 human Y710-p 464878 DVYSTDYyRLFNPSG PK_Tyr_Ser-Thr carcinogenesis, induced; signaling pathway regulation 10702799 1 0 10 +Map2 MAP2 iso3 Cytoskeletal; Motility/polarity/chemotaxis P15146-3 25595 9q32 rat K328-ac 62495518 DNIKYQPkGGQVQIV Tubulin-binding cytoskeletal reorganization 28002468 1 1 0 +ANPEP CD13 EC 3.4.11.2; Membrane protein, integral; Other Amino Acids Metabolism - glutathione; Protease; Receptor, misc. P15144 290 15q26.1 human T63-p 1870824601 TTNPASAtTLDQSKA molecular association, regulation 14-3-3 sigma(INDUCES) 33109610 1 0 0 +Rab8a RAB8A G protein; G protein, monomeric; G protein, monomeric, Rab; Motility/polarity/chemotaxis; Oncoprotein P55258 17274 8 B3.3|8 34.84 cM mouse T72-p 4709152 AGQERFRtITTAYYR Ras autophagy, inhibited 37454104 13 5 6 +Pard6a PARD6A Adaptor/scaffold; Cell adhesion; Motility/polarity/chemotaxis Q9Z101 56513 8|8 D3 mouse S345-p 15714600 RGDVSGFsL______ cell growth, altered 20603020 2 9 0 +NR1H4 NR1H4 iso2 DNA-binding; Nuclear receptor Q96RI1-2 9971 12q23.1 human K275-sm 31089517 EITNKILkEEFSAEE Hormone_recep molecular association, regulation transcription, inhibited DNA(DISRUPTS) 23546875 1 0 0 +TJP2 ZO2 Adaptor/scaffold; Motility/polarity/chemotaxis Q9UDY2 9414 9q21.11 human K759-ub 1883981502 PDWFQTAkTEPKDAG protein stabilization; molecular association, regulation occludin(INDUCES); ZO1(INDUCES) 36291162 1 0 0 stability of hZO-2 is regulated by K48 polyubiquitin and K759, K997 ubiquitylation and K730 SUMOylation, mutations in ZO2 ubiquitylation and ylation sites disrupt the interaction with occludin and ZO1as well as tight junction (TJ) barrier function +SPI1 PU.1 DNA-binding; Oncoprotein; Transcription factor P17947 6688 11p11.2 human S140-p 451055 EEEGERQsPPLEVSD protein degradation; molecular association, regulation; ubiquitination cell differentiation, inhibited FBXW7(INDUCES) 33188146 2 2 0 +MYB Myb DNA-binding; Oncoprotein; Transcription factor P10242 4602 6q23.3 human K527-sm 486352 PPLLKKIkQEVESPT Cmyb_C sumoylation; intracellular localization transcription, inhibited 12631292 4 1 0 +KCNQ1 Kv7.1 Channel, potassium; Membrane protein, integral; Membrane protein, multi-pass P51787 3784 11p15.5-p15.4 human S95-p 4712797 DPRVSIYsTRRPVLA activity, inhibited 29452158 1 2 3 mediate the inhibition of Ang II on the current +Vim Vimentin Cytoskeletal; Motility/polarity/chemotaxis P20152 22352 2 A1|2 10.04 cM mouse S47-p 455455 LGSALRPsTSRSLYS Filament_head cytoskeletal reorganization 12458200 3 18 10 +Pa2g4 Ebp1 Nuclear receptor co-regulator; Nucleolus; Transcription, coactivator/corepressor Q6AYD3 288778 7q11 rat S360-p 478276 ELKALLQsSASRKTQ molecular association, regulation; intracellular localization cell growth, altered Rb(DISRUPTS); Akt1(INDUCES) 16642037; 21145366 5 2 1 +Cit CRIK EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, AGC; Protein kinase, Ser/Thr (non-receptor) P49025 12704 5|5 F mouse Y1246-p 57761910 LENIQVLySHEKVKM molecular association, regulation cell cycle regulation RHOA(INDUCES) 27551053 1 1 0 prevents the completion of cytokinesis +TTK TTK Cancer Testis Antigen (CTA); EC 2.7.12.1; KINASE; Kinase, protein; Protein kinase, Other; Protein kinase, dual-specificity (non-receptor) P33981 7272 6q14.1 human S363-p 1737601 LKNKTESsLLAKLEE intracellular localization; enzymatic activity, induced cell cycle regulation 25265012; 26119734 4 4 0 regulates spindle assembly checkpoint and recruitment of SAC proteins; autophosphorylation of this site is required for release TTK from kinetochore; causes decreased kinetochore localization of BubR1 and Mad2. +ITGA4 ITGA4 Cell adhesion; Membrane protein, integral; Motility/polarity/chemotaxis; Receptor, misc. P13612 3676 2q31.3 human S1021-p 469620 QEENRRDsWSYINSK activity, induced; molecular association, regulation; phosphorylation carcinogenesis, induced; cell motility, induced; cell growth, inhibited; cell motility, altered; cytoskeletal reorganization PXN(DISRUPTS); PXN(INDUCES); syndecan-1(INDUCES); PXN iso2(DISRUPTS) 11533025; 12837751; 17603879; 18583710; 23979717; 31562188 8 33 111 +Stmn2 STMN2 Cytoskeletal P21818 84510 2q23 rat S97-p 455607 AAEGRRKsQEAQVLK Stathmin molecular association, regulation; activity, inhibited cytoskeletal reorganization TUBA1A(DISRUPTS); TUBB(DISRUPTS) 15825189; 9525956 5 3 1 +SVIL supervillin Actin-binding; Contractile; Motility/polarity/chemotaxis; Nuclear receptor co-regulator O95425 6840 10p11.23 human S238-p 468886 SFSGRDSsFTEVPRS molecular association, regulation; intracellular localization; phosphorylation cell cycle regulation PRC1(INDUCES) 23750008 1 29 1 inhibits aberrant furrowing, activates myosin II ; plays a role in cytokinesis +Ttc5 TTC5 Adaptor/scaffold Q99LG4 219022 14|14 C1 mouse S203-p 12559514 TGQNPKIsQQALSAY intracellular localization apoptosis, induced p300(INDUCES) 15448695 2 0 0 apoptosis in response to DNA damage +Gdi1 GDI1 G protein regulator, misc.; Motility/polarity/chemotaxis P50398 25183 Xq37 rat S213-p 12607403 INRIKLYsESLARYG GDI molecular association, regulation Rab4(INDUCES) 20051515 1 0 0 facilitates the membrane trafficking of AMPARs +PRMT5 PRMT5 Cell cycle regulation; EC 2.1.1.125; METHYLTRANSFERASE; Methyltransferase; Methyltransferase, protein arginine; RNA processing O14744 10419 14q11.2 human T139-p 1267669102 TNLARVLtNHIHTGH PRMT5_TIM enzymatic activity, induced 30289978 1 0 0 +RALGAPA2 RALGAPA2 GAP; GAP, Ras Q2PPJ7 57186 20p11.23 human S486-p 485552 SSWGRTYsFTSAMSR carcinogenesis, induced; signaling pathway regulation 22580611 2 20 39 cell invasion induced +NFKBIA IkB-alpha DNA-binding; Inhibitor P25963 4792 14q13.2 human Y42-p 448737 DSMKDEEyEQMVKEL activity, induced; protein degradation; molecular association, regulation apoptosis, inhibited; transcription, induced; transcription, altered NFkB-p65(DISRUPTS) 10754328; 11266466; 12432072; 12909638; 17533369; 8797825 15 1 28 +Ctnnb1 CTNNB1 Actin-binding; Cell adhesion; Motility/polarity/chemotaxis; Nuclear receptor co-regulator; Oncoprotein; Transcription factor Q02248 12387 9 F4|9 72.19 cM mouse S605-p 3545003 LFVQLLYsPIENIQR Arm intracellular localization 18423204 3 0 0 +NPAT NPAT Cell cycle regulation; Transcription regulation Q14207 4863 11q22.3 human S775-p 2286404 LPTIILSsPTKSPTK NPAT_C transcription, induced 10995387 1 2 0 multiple sites deletion mutant +PLA2G4A PLA2G4A EC 3.1.1.4; EC 3.1.1.5; Lipid Metabolism - alpha-linolenic acid; Lipid Metabolism - arachidonic acid; Lipid Metabolism - ether lipid; Lipid Metabolism - glycerophospholipid; Lipid Metabolism - linoleic acid; Phospholipase P47712 5321 1q31.1 human S228-p 450089 ATYVAGLsGSTWYMS PLA2_B activity, induced; enzymatic activity, induced 15539760; 18280113 4 0 0 S228 induced full activity, S505 partially +APC APC Motility/polarity/chemotaxis; Tumor suppressor P25054 324 5q22.2 human S1505-p 452096 DGFSCSSsLSALSLD APC_r molecular association, regulation; phosphorylation CTNNB1(INDUCES) 12628243; 17910481 2 0 0 phosphorylation by CK1 primes for S1501 phosphorylation by GSK3; based on acidic phospho-mimetic mutant +Ajuba JUB Cell adhesion; Motility/polarity/chemotaxis; Transcription, coactivator/corepressor Q91XC0 16475 14|14 C2 mouse T172-p 22499900 SRPCSNRtSGISMGY molecular association, regulation RAC1(INDUCES) 22105346 1 1 0 necessary for Rac activation by junctions +IRF7 IRF7 DNA-binding; Transcription factor Q92985 3665 11p15.5 human K452-ub 4666609 EKSLVLVkLEPWLCR IRF-3 transcription, induced 18710948 1 1 0 +Bcl2l11 BIM Apoptosis O88498 64547 3q36 rat K108-ub 25087002 PAPMSCDkSTQTPSP protein degradation 21378313 2 0 0 BIM was still degraded in the absence of these lysines defining a novel ubiquitin-independent pathway. +PTEN PTEN Carbohydrate Metabolism - inositol phosphate; EC 3.1.3.16; EC 3.1.3.48; EC 3.1.3.67; Motility/polarity/chemotaxis; Nuclear receptor co-regulator; PHOSPHATASE; Phosphatase, lipid; Tumor suppressor P60484 5728 10q23.31 human K60-ub 1881390901 VVRFLDSkHKNHYKI protein degradation; phosphorylation 34785642 1 0 0 AKT S473 increased ; regulates the HCC cell chemoresistance (chemoresistant) +Stxbp1 STXBP1 Vesicle P61765 25558 3p11 rat S313-p 448744 SLKDFSSsKRMNTGE Sec1 molecular association, regulation; intracellular localization exocytosis, altered STX1A(DISRUPTS) 15489225; 16997485; 29946239 7 0 0 regulates protein secretion by increasing vesicle pools replenishment after stimulation +PIP4K2C PIP4K2C Carbohydrate Metabolism - inositol phosphate; EC 2.7.1.149; Endoplasmic reticulum; Kinase, lipid; Motility/polarity/chemotaxis Q8TBX8 79837 12q13.3 human S328-p 34431500 LVGSYGTsPEGIGGY PIP5K intracellular localization; phosphorylation cell growth, inhibited; signaling pathway regulation 25372051 1 1 0 inhibits expression of phosphorylated p70S6K and S6, inhibits mTORC1 signaling, regulates cell size +FNIP1 FNIP1 Q8TF40 96459 5q31.1 human K1119-ub 1871197700 QELYFKSkMLSEYLR FNIP_C protein degradation; ubiquitination 30699359 1 0 0 +UBTF UBF DNA-binding; Nucleolus; Transcription factor P17480 7343 17q21.31 human S389-p 450170 INKKQATsPASKKPA transcription, induced 24798431 4 3 1 rDNA transcription +CASP1 CASP1 Apoptosis; EC 3.4.22.36; Protease P29466 834 11q22.3 human S376-p 469562 IFRKVRFsFEQPDGR Peptidase_C14 enzymatic activity, induced 15561713 1 0 0 +BUB1B BUB1B EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, Other; Protein kinase, Ser/Thr (non-receptor); Tumor suppressor O60566 701 15q15.1 human S884-p 20727431 EIVHGDLsPRCLILR enzymatic activity, inhibited cell cycle regulation 22698286 0 3 0 +PIK3C3 PIK3C3 Autophagy; Carbohydrate Metabolism - inositol phosphate; EC 2.7.1.137; Kinase, lipid; Motility/polarity/chemotaxis Q8NEB9 5289 18q12.3 human K29-ac 280006402 KIGSLEGkREQKSYK molecular association, regulation; enzymatic activity, inhibited autophagy, inhibited beclin 1(DISRUPTS) 28844862 1 1 0 nutrient starvation-induced autophagy +Cnbp ZNF9 DNA-binding; RNA-binding; Transcription factor P53996 12785 6|6 D1 mouse T173-p 471955 GHLARECtIEATA__ zf-CCHC molecular association, regulation; protein stabilization; intracellular localization cell growth, induced; transcription, induced; translation, induced SUFU(INDUCES) DNA(INDUCES) 26460945; 34168080 2 5 9 regulates Type I IFN promoter activity; translation of ornithine decarboxylase (ODC) +ESRRA ERR1 DNA-binding; Nuclear receptor; Transcription regulation P11474 2101 11q13.1 human K160-ac 15211512 RVRGGRQkYKRRPEV molecular association, regulation transcription, inhibited DNA(DISRUPTS) 20484414 1 0 0 +Ptk2b Pyk2 EC 2.7.10.2; KINASE; Kinase, protein; Nuclear receptor co-regulator; Protein kinase, TK; Protein kinase, tyrosine (non-receptor) Q9QVP9 19229 14 D1|14 34.36 cM mouse Y402-p 447955 CSIESDIyAEIPDET molecular association, regulation; phosphorylation; enzymatic activity, induced carcinogenesis, induced; apoptosis, induced; cell adhesion, induced; transcription, altered; neural plasticity; cell growth, induced; cytoskeletal reorganization; cell adhesion, altered DYN1(INDUCES); Src(INDUCES); Src iso1(INDUCES) 11149930; 12514172; 14739300; 16901726; 17581824; 19380485; 34529077; 35536885; 36038818 86 2 22 +OSBP2 OSBP2 Q969R2 23762 22q12.2 human S763-p 31727226 CSKVMHSsPSSPSSD Oxysterol_BP molecular association, regulation; protein conformation signaling pathway regulation Vimentin(INDUCES) 30925160 1 2 0 +Bcl2l11 BIM Apoptosis O54918 12125 2|2 F1 mouse Y92-p 56650528 LSRSSSGyFSFDTDR protein stabilization apoptosis, inhibited 29391601 1 1 0 +GLDC GLDC Amino Acid Metabolism - glycine, serine and threonine; EC 1.4.4.2; Oxidoreductase P23378 2731 9p24.1 human K514-ac 1186987 GIPGSVFkRTSPFLT protein degradation; enzymatic activity, inhibited carcinogenesis, inhibited; cell growth, inhibited 34244482 1 3 24 inhibits glycine catabolism and pyrimidine synthesis, suppresses tumorigenesis +Gabrb1 GABRB1 Channel, chloride; Channel, ligand-gated; Membrane protein, integral; Membrane protein, multi-pass; Transporter; Transporter, ion channel P50571 14400 5 C3.2|5 38.18 cM mouse S409-p 451812 IQYRKPLsSREGFGR Neur_chan_memb activity, induced; receptor desensitization, altered 10195104; 1323140 4 0 0 reduces rate of receptor internalization +PRKAA2 AMPKA2 Autophagy; EC 2.7.11.1; EC 2.7.11.27; EC 2.7.11.31; KINASE; Kinase, protein; Protein kinase, CAMK; Protein kinase, Ser/Thr (non-receptor) P54646 5563 1p32.2 human T172-p 448026 SDGEFLRtSCGSPNY Pkinase activity, induced; protein degradation; intracellular localization; phosphorylation; enzymatic activity, induced cell cycle regulation; carcinogenesis, induced; carcinogenesis, altered; carcinogenesis, inhibited; apoptosis, induced; cell growth, inhibited; transcription, altered; signaling pathway regulation; autophagy, induced; apoptosis, inhibited; cytoskeletal reorganization; transcription, inhibited 12391032; 15465812; 22304913; 22456184; 22561688; 23612973; 23716691; 23863464; 23982736; 32102879; 32209483; 32209654; 33755959; 33760042; 33898950; 34064003; 34193159; 34247189; 34421352; 34482636; 34604061; 34673141; 34787456; 34820368; 34921013; 34998825; 35035775; 35061665; 35290799; 35508122; 35522655; 35582406; 35761398; 35780182; 35975969; 35977966; 36008391; 36079767; 36139911; 36243112; 36387221; 36481655; 36611139; 36690274 220 13 33 +NLRP3 NLRP3 Inhibitor Q96P20 114548 1q44 human K496-ub 10998766 LRNHGLQkADVSAFL NOD2_WH protein degradation 32929041 2 1 1 +LEF1 LEF-1 DNA-binding; Transcription factor Q9UJU2 51176 4q25 human S42-p 471384 EKIFAEIsHPEEEGD CTNNB1_binding molecular association, regulation transcription, induced CTNNB1(INDUCES) 17113388 1 3 4 +MCM2 MCM2 DNA-binding; EC 3.6.4.12 P49736 4171 3q21.3 human S108-p 456310 DVEELTAsQREAAER MCM2_N molecular association, regulation; phosphorylation cell cycle regulation; carcinogenesis, induced; cell growth, induced; chromatin organization, altered FANCD2(INDUCES); FANCM(INDUCES); SIRT1(INDUCES) DNA(INDUCES) 16446360; 23993743; 31067464; 31776133; 35524559; 36082941 18 29 80 +TRPC6 TRPC6 Channel, cation; Membrane protein, integral; Membrane protein, multi-pass Q9Y210 7225 11q22.1 human S282-p 21358400 NAYKGLAsPAYLSLS TRP_2 phosphorylation signaling pathway regulation 23645677 2 0 0 increased ERK1 phosphorylation +DDR1 DDR1 EC 2.7.10.1; KINASE; Kinase, protein; Membrane protein, integral; Protein kinase, TK; Protein kinase, tyrosine (receptor) Q08345 780 6p21.33 human Y520-p 1026167 YRLLLATyARPPRGP activity, induced 24509848 1 9 86 phosphorylated in the N211QDDR1 mutant +Nr3c1 GR DNA-binding; Mitochondrial; Nuclear receptor; Transcription factor P06537 14815 18 B3|18 21.09 cM mouse S221-p 447967 DLEFSAGsPGKETNE GCR transcription, induced 21994940 20 7 0 +SUV39H1 SUV39H1 Amino Acid Metabolism - lysine degradation; EC 2.1.1.43; METHYLTRANSFERASE; Methyltransferase; Methyltransferase, protein lysine O43463 6839 Xp11.23 human K87-ub 63128901 LKCVRILkQFHKDLE Chromo protein degradation 28059589 1 2 0 +Cdh1 CDH1 Cell adhesion; Membrane protein, integral; Motility/polarity/chemotaxis; UBIQUITIN LIGASE; Ubiquitin ligase P09803 12550 8 D3|8 53.18 cM mouse S842-p 15754600 FDYEGSGsEAASLSS CADH_Y-type_LIR molecular association, regulation CTNNB1(INDUCES) 11348595 5 1 0 +Mef2d MEF2D DNA-binding; Transcription factor O89038 81518 2q34 rat T145-p 10359101 PNFAMPVtVPVSNQS HJURP_C activity, inhibited apoptosis, altered; transcription, inhibited 19801631 1 0 0 +Polb POLB DNA repair, damage; DNA replication; EC 2.7.7.7; Lyase; Transferase P06766 29240 16q12.5 rat S44-p 41521700 NAYRKAAsVIAKYPH HHH_8 enzymatic activity, inhibited 2040602 4 1 0 +MAP4 MAP4 Cytoskeletal; Motility/polarity/chemotaxis P27816 4134 3p21.31 human K1070-ac 62495528 FKEKAQAkVGSLDNV Tubulin-binding cytoskeletal reorganization 28002468 1 1 0 +WWTR1 TAZ Oncoprotein; Transcription, coactivator/corepressor Q9GZV5 25937 3q25.1 human T175-p 41594203 LHPAVSStPVPQRSM protein degradation 26183396 1 0 0 +GIT1 GIT1 GAP; GAP, ARF; Motility/polarity/chemotaxis Q9Y2X7 28964 17q11.2 human Y545-p 448965 ELEDDAIySVHVPAG molecular association, regulation cell motility, induced PXN(DISRUPTS); Hic-5(DISRUPTS) 25742295 4 39 737 phosphorylation-dephosphorylation required for coordinated cell movement, Y545-p was essential for Git1-mediated protrusion activity. +Kcnj8 KCNJ8 Channel, potassium; Membrane protein, integral; Membrane protein, multi-pass Q63664 25472 4q44 rat S397-p 471151 NSMRRSNsIRRNNSS activity, inhibited 18048350 1 2 0 +ULK1 ULK1 Autophagy; EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, Other; Protein kinase, Ser/Thr (non-receptor) O75385 8408 12q24.33 human S533-p 31868990 AEMRGGRsPRPGSSA protein degradation; molecular association, regulation; ubiquitination; enzymatic activity, inhibited cell growth, induced; apoptosis, inhibited; autophagy, inhibited ATG13(DISRUPTS); ATG101(DISRUPTS); RB1CC1(DISRUPTS) 31378785 1 5 0 regulates resistance of gliomas to TMZ +DDR1 DDR1 EC 2.7.10.1; KINASE; Kinase, protein; Membrane protein, integral; Protein kinase, TK; Protein kinase, tyrosine (receptor) Q08345 780 6p21.33 human Y586-p 1869973809 GVTGGNTyAVPALPP enzymatic activity, induced 32839343 1 1 0 +CREB1 CREB DNA-binding; Transcription factor P16220 1385 2q33.3 human S257-p 14159739 PGVVMASsPALPTQP molecular association, regulation cell cycle regulation; transcription, induced; transcription, inhibited CBP(INDUCES) DNA(DISRUPTS) 20573984; 23814058; 37098980 4 8 0 +Ilk ILK EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, Ser/Thr (non-receptor); Protein kinase, TKL O55222 16202 7|7 E3 mouse S246-p 479407 CPRLRIFsHPNVLPV PK_Tyr_Ser-Thr enzymatic activity, induced 28739876 8 0 0 +Arhgap18 ARHGAP18 GAP; GAP, Rac/Rho Q8K0Q5 73910 10|10 A4 mouse T156-p 4760950 RVETVSQtLRKKNKQ cytoskeletal reorganization 25456499 1 6 2 spine development +BLNK BLNK Adaptor/scaffold Q8WV28 29760 10q24.1 human Y178-p 447716 LLEDEADyVVPVEDN molecular association, regulation transcription, altered PLCG1(INDUCES); PLCG2(INDUCES); Btk(INDUCES); NCK2(INDUCES); VAV1(INDUCES) 12456653; 9697839 2 3 7 +KHSRP KHSRP RNA-binding Q92945 8570 19p13.3 human S132-p 482096 SQGDSISsQLGPIHP activity, induced; molecular association, regulation 21329876 1 2 12 binds to and functions in pri-miRNA processing +Map2k1 MEK1 EC 2.7.12.2; KINASE; Kinase, protein; Protein kinase, STE; Protein kinase, dual-specificity (non-receptor) Q01986 170851 8q24 rat S298-p 448284 RTPGRPLsSYGMDSR Pkinase intracellular localization; phosphorylation; enzymatic activity, induced cell cycle regulation; cytoskeletal reorganization; cell adhesion, altered 12876277; 17314031 25 4 1 Phosphorylation stimulates autophosphorylation on S217/S222.; activation of MEK1 and ERK1/2 +OTULIN FAM105B EC 3.4.19.12 Q96BN8 90268 5p15.2 human K64-ub 12327312 RAADEIEkEKELLIH protein conformation FAM105B(INDUCES) 35939695 1 4 4 genotoxic stress induces FAM105B dimerization, FAM105B self-deubiquitination, NF-kB Activation +KIF23 KIF23 Microtubule-binding; Motility/polarity/chemotaxis; Motor Q02241 9493 15q23 human S814-p 470674 LRHRRSRsAGDRWVD MKLP1_Arf_bdg molecular association, regulation cell cycle regulation 14-3-3 beta(INDUCES); 14-3-3 zeta(INDUCES); LIMK1(INDUCES) 22580824; 25658096; 25786116 5 7 0 S716 phosphorylation is necessary for S814 phosphorylation; activation of LIMK1 on centrosomes; active S814 dephosphorylation after abscission ; ARF6 can prevent access of 14-3-3 to centralspindlin and preserve the assembly from dissipation by 14-3-3 during cytokinesis. +Npy1r NPY1R GPCR, family 1; Membrane protein, integral; Membrane protein, multi-pass; Receptor, GPCR P21555 29358 16p14 rat T356-p 2815302 IAMSTMHtDVSKTSL receptor desensitization, altered; receptor internalization, altered 15576634 1 0 1 may be an artifact of the truncation mutants +CTNNB1 CTNNB1 Actin-binding; Cell adhesion; Motility/polarity/chemotaxis; Nuclear receptor co-regulator; Oncoprotein; Transcription factor P35222 1499 3p22.1 human T41-p 447583 GIHSGATtTAPSLSG protein degradation; protein stabilization; molecular association, regulation; ubiquitination; intracellular localization; activity, inhibited; neddylation cell cycle regulation; carcinogenesis, induced; carcinogenesis, inhibited; apoptosis, induced; cell growth, inhibited; transcription, induced; cell motility, inhibited; signaling pathway regulation; transcription, altered; cell adhesion, altered; cytoskeletal reorganization; transcription, inhibited; cell growth, altered CBLL1(INDUCES); TRAF2(DISRUPTS) 12000790; 17018282; 19060929; 19667122; 20300119; 20419129; 22025562; 32041324; 32046730; 32210470; 33651074; 33832512; 34117362; 34290402; 34326276; 34749529; 35064015; 35065073; 35108540; 35320710; 35347116; 35879396; 36575468; 36941998; 37369481; 37400529 102 3 0 +PGAM1 PGAM1 Carbohydrate Metabolism - glycolysis and gluconeogenesis; EC 3.1.3.13; EC 5.4.2.11; EC 5.4.2.4; Isomerase; Phosphatase (non-protein) P18669 5223 10q24.1 human H11-p 27939200 YKLVLIRhGESAWNL His_Phos_1 enzymatic activity, induced cell growth, inhibited 15181008; 8477721 4 0 0 PGMtide (LIRHGE) promoted growth arrest of several tumor cell lines, but not in non-tumor cells or in the presence of pyruvate. +NUMA1 NuMA-1 Cell cycle regulation; Motility/polarity/chemotaxis Q14980 4926 11q13.4 human S1969-p 3196643 QETLRRAsMQPIQIA intracellular localization cell cycle regulation 26832443 2 39 43 promotes correct spindle orientation +Fgfr2 FGFR2 EC 2.7.10.1; KINASE; Kinase, protein; Membrane protein, integral; Oncoprotein; Protein kinase, TK; Protein kinase, tyrosine (receptor) P21803 14183 7|7 F3 mouse Y769-p 448113 TLTTNEEyLDLTQPL molecular association, regulation; protein conformation PLCG1(INDUCES) 26687682 5 1 0 +GABBR1 GABBR1 GPCR, family 3; Membrane protein, integral; Membrane protein, multi-pass; Receptor, GPCR Q9UBS5 2550 6p22.1 human K887-ub 54191602 TNNNEEEkSRLLEKE protein degradation; ubiquitination 26817839 1 0 0 +Dclre1c Artemis DNA repair, damage; Deoxyribonuclease; EC 3.1.-.- Q8K4J0 227525 2|2 A1 mouse S518-p 460660 SSIETGGsQSPKLCS cell growth, induced 22476261 8 3 1 +EP300 p300 ACETYLTRANSFERASE; Acetyltransferase; EC 2.3.1.48; Motility/polarity/chemotaxis; Nuclear receptor co-regulator; Transcription, coactivator/corepressor Q09472 2033 22q13.2 human S89-p 447592 SELLRSGsSPNLNMG acetylation; molecular association, regulation; enzymatic activity, inhibited carcinogenesis, induced; cell motility, induced; transcription, induced; transcription, inhibited PPAR-gamma(DISRUPTS); LRP6(INDUCES); RARG(DISRUPTS); TR-beta1(DISRUPTS); RXRA(DISRUPTS) 11020388; 11518699; 12379484; 15006641; 21940946; 26140605; 34261798; 35409338 14 2 0 +IL4R IL4R Membrane protein, integral; Receptor, cytokine P24394 3566 16p12.1 human Y497-p 451065 VIAGNPAyRSFSNSL apoptosis, inhibited 9670964 3 0 0 +IRF8 IRF8 DNA-binding; Transcription factor Q02556 3394 16q24.1 human Y110-p 2299203 ISEPYKVyRIVPEEE IRF transcription, inhibited; transcription, altered 11483597; 18195016 2 0 0 represses PTPN13 promoter activity +Foxo3 FOXO3A Autophagy; DNA-binding; Oncoprotein; Transcription factor Q9WVH4 56484 10 B2|10 22.79 cM mouse T32-p 448602 QSRPRSCtWPLQRPE protein degradation; molecular association, regulation; intracellular localization cell cycle regulation; carcinogenesis, induced; apoptosis, altered; signaling pathway regulation; cell growth, induced; apoptosis, inhibited; cytoskeletal reorganization; transcription, inhibited; cell growth, altered; translation, inhibited 14-3-3 beta(INDUCES); p300(DISRUPTS); 14-3-3 zeta(INDUCES) 10102273; 11154281; 11864996; 11896584; 14981546; 17077388; 19325558; 19942091; 20332342; 21804606; 33795838 74 8 91 +KNL1 CASC5 Cancer Testis Antigen (CTA); Cell cycle regulation Q8NG31 57082 15q15.1 human T1155-p 37046601 GQDDMEItRSHTTAL MELT phosphorylation 25402682 2 1 0 A mutants increased BUB1B S670 +DNM2 DYN2 EC 3.6.5.5; Hydrolase; Microtubule-binding; Motility/polarity/chemotaxis; Vesicle P50570 1785 19p13.2 human S848-p 3059607 GIPPGVPsRRPPAAP molecular association, regulation; intracellular localization PIK3C2A(DISRUPTS) 12205083 2 1 0 +EEF2 EEF2 Translation; Translation elongation P13639 1938 19p13.3 human K529-sm 32005104 EGLKRLAkSDPMVQC EFG_III phosphorylation 24648518 1 0 0 induces tyrosine phosphorylation of itself +JAK2 JAK2 EC 2.7.10.2; KINASE; Kinase, protein; Oncoprotein; Protein kinase, TK; Protein kinase, tyrosine (non-receptor) O60674 3717 9p24.1 human Y119-p 470132 VLYRIRFyFPRWYCS FERM_F1 protein stabilization; enzymatic activity, inhibited EPOR(DISRUPTS) 17024180 2 0 0 +INSIG1 INSIG1 Membrane protein, integral; Membrane protein, multi-pass O15503 3638 7q36.3 human S207-p 1868515111 LWWTFDRsRSGLGLG INSIG activity, induced; protein degradation; molecular association, regulation carcinogenesis, induced; cell growth, induced; apoptosis, inhibited; transcription, induced SCAP(INDUCES) 32322062; 33842305 2 1 0 +Rfc1 RFC1 DNA replication D3ZFT1 89809 14p11 rat S69-p 452680 KKRIIYDsDSESEET intracellular localization transcription, inhibited 10625661 1 64 5 +EPAS1 HIF2A DNA-binding; Transcription factor Q99814 2034 2p21 human K394-sm 12723519 NFLFTKLkEEPEELA transcription, inhibited 20026589 1 0 0 +DNMT1 DNMT1 Amino Acid Metabolism - cysteine and methionine; Cell development/differentiation; EC 2.1.1.37; METHYLTRANSFERASE; Methyltransferase; Methyltransferase, DNA; Transcription regulation P26358 1786 19p13.2 human K160-ac 25171011 PSPRITRkSTRQTTI cell cycle regulation 21947282 1 1 0 +Agtr1 AT1 GPCR, family 1; Membrane protein, integral; Membrane protein, multi-pass; Receptor, GPCR P25095 24180 17p12 rat S335-p 467238 SSLSTKMsTLSYRPS molecular association, regulation ARRB2(INDUCES) 29146594 3 1 0 BRET +XBP1 XBP1 DNA-binding; Transcription factor P17861 7494 22q12.1|22q12 human K77-ub 1878023501 EEKALRRkLKNRVAA bZIP_2 protein degradation; ubiquitination; intracellular localization transcription, inhibited 31837300 1 0 0 K60/77R enhances the nuclear localization, enhances insulin sensitivity in the hepatocyte and in db/db mice, maintains glucose homeostasis in DIO mice, alleviates ER stress in DIO mice, increases its protein abundance, transcriptional activity +TDP2 TTRAP EC 3.1.4.-; Inhibitor; Nucleolus O95551 51567 6p22.3 human S60-p 52421901 EMERALNsYFEPPVE UBA_4 enzymatic activity, induced DNA repair, induced 26701725 1 1 0 +ADIPOR1 ADIPOR1 Membrane protein, integral; Membrane protein, multi-pass Q96A54 51094 1q32.1 human S205-p 1877164900 EKVSRTFsKLDYSGI HlyIII protein degradation; molecular association, regulation; phosphorylation endocytosis, induced; apoptosis, inhibited; signaling pathway regulation LAMP2(INDUCES); RAB5A(INDUCES) 35611695 1 0 0 inhibits APN signaling, resulting in inhibition of ERK, AMPK and ACC phosphorylation +Usp15 USP15 DEUBIQUITINASE; EC 3.4.19.12; Protease; Ubiquitin conjugating system; Ubiquitin-specific protease Q8R5H1 14479 10|10 D2 mouse S678-p 11952926 LPSENENsQSEDSVG UCH molecular association, regulation; ubiquitination; intracellular localization DNA repair, induced MDC1(INDUCES) 30874560 2 1 0 translocate into nuclei following IR, induce genome stability, homologous recombination (HR) repair; deubiquitinates BARD1 +SESN2 SESN2 P58004 83667 1p35.3 human K13-ub 573766050 SECRAELkDYLRFAP protein degradation 31586034 1 2 0 leucine-dependent nutrient sensing +Cdk5 CDK5 Cell cycle regulation; EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, CMGC; Protein kinase, Ser/Thr (non-receptor) P49615 12568 5 A3|5 11.73 cM mouse Y15-p 448022 EKIGEGTyGTVFKAK Pkinase enzymatic activity, induced cell differentiation, induced; transcription, induced; cytoskeletal reorganization; signaling pathway regulation 10896159; 18948252; 21813649; 33798451 17 47 894 +PARD3 PAR3-alpha Adaptor/scaffold; Motility/polarity/chemotaxis Q8TEW0 56288 10p11.22-p11.21 human S827-p 467266 REGFGRQsMSEKRTK phosphorylation PKCI(DISRUPTS) 27554858 7 11 0 apical-junctional polarization +NR5A1 STF-1 Nuclear receptor; Transcription, coactivator/corepressor Q13285 2516 9q33.3 human K194-sm 2798300 AFPGRAIkSEYPEPY sumoylation; molecular association, regulation; intracellular localization transcription, inhibited RAD54L2(INDUCES) DNA(INDUCES) 15192092; 19692572 9 0 0 +USP24 USP24 DEUBIQUITINASE; EC 3.4.19.12; Protease; Ubiquitin-specific protease Q9UPU5 23358 1p32.3 human S2047-p 451983 QRVSDQNsPVLPKKS protein degradation cell cycle regulation 27991932 1 85 3 +Nphs1 NPHS1 Cell adhesion; Immunoglobulin superfamily; Membrane protein, integral Q9QZS7 54631 7|7 B1 mouse Y1232-p 469566 YEDPRGIyDQVAADM molecular association, regulation cytoskeletal reorganization NCK1(INDUCES) 18212058 10 0 0 +ACADVL ACADVL EC 1.3.8.9; Lipid Metabolism - fatty acid; Mitochondrial; Oxidoreductase P49748 37 17p13.1 human K492-sc 40477506 SGLGSALkNPFGNAG molecular association, regulation CRLS1(INDUCES) 25811481 1 0 0 both SIRT3 and SIRT5 KO show reduced afinity for CRLS1 +FOXM1 FOXM1 iso2 DNA-binding; Transcription factor Q08050-2 2305 12p13.33 human S474-p 22648002 PPLEEWPsPAPSFKE ubiquitination 26912724 2 3 0 +MUC1 MUC1 Actin-binding; Cell adhesion; Membrane protein, integral; Motility/polarity/chemotaxis; Nuclear receptor co-regulator; Tumor suppressor P15941 4582 1q22 human Y1203-p 454878 IFPARDTyHPMSEYP activity, induced; molecular association, regulation; intracellular localization cell motility, altered AP2M1(INDUCES); AP1G1(INDUCES); PIK3R1(INDUCES) 15471854; 16507569; 17545600; 17586693 5 7 338 nuclear localization; Phosphorylation enhanced invasion in vitro, through Matrigel. ; Y1203 phosphorylation is necessary for binding of PI3KR1 and phosphorylation of AKt S473. +ESR1 ER-alpha DNA-binding; Nuclear receptor; Transcription factor P03372 2099 6q25.1-q25.2 human K171-ac 31094527 RLASTNDkGSMAMES Oest_recep protein stabilization transcription, induced 30787391 1 2 0 +WIZ WIZ C2H2-type zinc finger protein O95785 58525 19p13.12 human K967-m2 58097619 PAVNKAIkSPPGFSA molecular association, regulation L3MBTL iso4(INDUCES) 23583077 0 2 0 +FYN Fyn EC 2.7.10.2; KINASE; Kinase, protein; Oncoprotein; Protein kinase, TK; Protein kinase, tyrosine (non-receptor) P06241 2534 6q21 human Y185-p 465282 SETTKGAySLSIRDW SH2 molecular association, regulation; enzymatic activity, induced 27001024 1 29 286 autophosphorylation reduces its ability to bind to ESDN/DCBLD2; reduces SH2-dependent binding interactions +KDR VEGFR2 EC 2.7.10.1; KINASE; Kinase, protein; Membrane protein, integral; Protein kinase, TK; Protein kinase, tyrosine (receptor) P35968 3791 4q12 human R819-me 1878245900 PLDEHCErLPYDASK molecular association, regulation; phosphorylation cytoskeletal reorganization Src(INDUCES) 35942094 1 0 0 mediates filopodia in endothelial cells; induces phosphorylation at Y822 +HRAS HRas G protein; G protein, monomeric; G protein, monomeric, Ras; Motility/polarity/chemotaxis; Oncoprotein P01112 3265 11p15.5 human T35-p 450197 FVDEYDPtIEDSYRK Ras apoptosis, induced 9264402 1 0 0 +Mbp MBP iso5 Cytoskeletal P04370-5 17196 18 E3|18 55.84 cM mouse T93-p 455362 HFFKNIVtPRTPPPS Myelin_MBP molecular association, regulation; intracellular localization; protein conformation cytoskeletal reorganization Fyn(DISRUPTS) 21887699; 23861868 5 2 0 +PRKDC DNAPK DNA repair, damage; EC 2.7.11.1; KINASE; Kinase, protein; Nucleolus; Protein kinase, Ser/Thr (non-receptor); Protein kinase, atypical P78527 5591 8q11.21 human K3260-ac 11318529 SLAMKLLkELHKESK FAT DNA repair, induced 27297111 1 3 0 regulates genomic stability and radiosensitivity of cells +Gpsm2 GPSM2 G protein regulator, misc. Q8VDU0 76123 3|3 F3 mouse S408-p 4766076 AKLGRRHsMENLELM molecular association, regulation DLG1(INDUCES) 22117215 2 21 9 Fluorescence Polarization +SOCS3 SOCS3 Inhibitor O14543 9021 17q25.3 human Y204-p 450446 VNGHLDSyEKVTQLP protein degradation; molecular association, regulation transcription, altered TCEB1(DISRUPTS) 12783885; 16352613 5 2 12 +CYCS CYCS Apoptosis; Mitochondrial; Oxidoreductase; PHOSPHATASE; Protein phosphatase, Ser/Thr (non-receptor) P00004 100053958 horse K9-ac 467108 GDVEKGKkIFVQKCA Cytochrom_C enzymatic activity, induced 19645667 1 4 0 +ROS1 ROS EC 2.7.10.1; KINASE; Kinase, protein; Membrane protein, integral; Oncoprotein; Protein kinase, TK; Protein kinase, tyrosine (receptor) P08922 6098 6q22.1 human Y2334-p 454392 GKPEGLNyACLTHSG molecular association, regulation SHP-1(INDUCES) 15456853 1 3 17 Mutation of Y2334 reduced constitutive association of ROS with SHP-1. +CLTC CLTC Motility/polarity/chemotaxis; Vesicle Q00610 1213 17q23.1 human Y1477-p 448069 LFITEEDyQALRTSI Clathrin molecular association, regulation; intracellular localization Syk(INDUCES) 10089883; 19289168 2 11 156 +EIF4EBP2 4E-BP2 Translation; Translation initiation Q13542 1979 10q22.1 human T37-p 449367 LPHDYCTtPGGTLFS eIF_4EBP molecular association, regulation; protein conformation 4E-BP1(DISRUPTS) 25533957 4 26 44 +XRCC4 XRCC4 DNA repair, damage Q13426 7518 5q14.2 human K210-sm 3656303 QEREKDIkQEGETAI XRCC4 intracellular localization DNA repair, induced 16478998; 25934149 2 0 0 +MCL1 MCL1 Apoptosis; Channel, misc.; Inhibitor; Membrane protein, integral; Mitochondrial Q07820 4170 1q21.2 human S162-p 59032201 STDGSLPsTPPPAEE protein stabilization 27738316 1 0 0 +GCH1 GCH1 Cofactor and Vitamin Metabolism - folate biosynthesis; EC 3.5.4.16; Hydrolase P30793 2643 14q22.2 human S81-p 487495 AYSSILSsLGENPQR GTP_cyclohydroI molecular association, regulation; enzymatic activity, induced GCHFR(DISRUPTS) 17704208; 19926872 4 0 0 +Cacna1e CACNA1E Channel, calcium; Membrane protein, integral; Membrane protein, multi-pass Q07652 54234 13q21 rat S1995-p 455594 GGRERGRsKERKHLL activity, induced 15840578 1 0 0 potentiation of Ca(2+) currents +F3 F3 Cell surface; Membrane protein, integral P13726 2152 1p21.3 human S285-p 451611 RKAGVGQsWKENSPL molecular association, regulation; ubiquitination; intracellular localization; protein conformation; phosphorylation apoptosis, altered; cell motility, altered; cell growth, altered FLNA(INDUCES) 12920028; 15039423; 15630487; 18297283; 20076769; 21310953; 27599717; 29044292 10 0 0 promotes angiogenesis; accelerates the incorporation of F3 into microparticles and induces S290 phosphorylation +PAK2 PAK2 EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, STE; Protein kinase, Ser/Thr (non-receptor) Q13177 5062 3q29 human S64-p 4760282 FSGTEKGsKKKEKER carcinogenesis, inhibited; signaling pathway regulation 30131370 1 10 0 +Slc12a5 KCC2 iso2 Membrane protein, integral; Membrane protein, multi-pass; Transporter; Transporter, SLC family Q91V14-2 57138 2|2 H3 mouse S932-p 27723627 EREREIQsITDESRG SLC12 activity, induced 30201606 2 2 0 transport activity increased +Rock2 ROCK2 EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, AGC; Protein kinase, Ser/Thr (non-receptor) P70336 19878 12|12 A1.1 mouse Y722-p 464192 LADKNKIyESIEEAK molecular association, regulation cell motility, altered; cytoskeletal reorganization RHOA(DISRUPTS) 20826462 5 7 127 +PTGIR PTGIR GPCR, family 1; Membrane protein, integral; Membrane protein, multi-pass; Receptor, GPCR P43119 5739 19q13.32 human S328-p 450985 TPLSQLAsGRRDPRA receptor desensitization, altered 9722557 3 0 0 S328A mutant had markedly reduced level of desensitization +Pde4b PDE4B EC 3.1.4.53; Nucleotide Metabolism - purine; Phosphodiesterase P14646 24626 5q33 rat S133-p 449097 GHSQRREsFLYRSDS enzymatic activity, induced 12441002 4 22 1 +Sp1 SP1 C2H2-type zinc finger protein; DNA-binding; Transcription factor Q01714 24790 7q36 rat T740-p 448227 SEGSGTAtPSALITT transcription, induced 21115498 17 1 0 induced by carbon monoxide +ZAP70 ZAP70 EC 2.7.10.2; KINASE; Kinase, protein; Protein kinase, TK; Protein kinase, tyrosine (non-receptor) P43403 7535 2q11.2 human Y292-p 447586 DTLNSDGyTPEPARI protein degradation; molecular association, regulation; intracellular localization; enzymatic activity, inhibited; phosphorylation cell adhesion, altered; transcription, altered; cell growth, altered CBL(INDUCES) 10779765; 11514605; 11976341; 15100278; 17579062; 8756661 10 14 447 leads to decreased LAT, Cbl, CD3-Zeta, and PLC-gamma-1 phosphorylation; inhibits Ca(2+) mobilization; inhibits PI3K activation and adhesion +A1cf ACF Hydrolase; RNA processing; RNA-binding Q923K9 170912 1q52 rat S368-p 473055 PATKGHLsNRALIRT activity, induced 17229474 1 0 0 enhances ApoB mRNA editing +HSP90AB1 HSP90B Chaperone; Heat shock protein P08238 3326 6p21.1 human S255-p 449266 PKIEDVGsDEEDDSG HSP90 activity, induced; molecular association, regulation; protein processing; intracellular localization; protein conformation apoptosis, altered; apoptosis, induced HSP40(DISRUPTS); AHSA1(DISRUPTS); PXR(INDUCES); APAF(DISRUPTS); CACYBP(INDUCES); DNAJC7(DISRUPTS); HSC70(DISRUPTS); CDC37(DISRUPTS); GR(DISRUPTS) 18591256; 25995454; 29854279; 34359868 10 131 410 induced by triptolide +Tdg TDG DNA repair, damage; EC 3.2.2.29; Hydrolase; Nuclear receptor co-regulator P56581 21665 10 C1|10 39.72 cM mouse K94-ac 458994 PKKPATSkKSGKSTK molecular association, regulation; acetylation; phosphorylation DNA repair, induced; chromatin organization, altered; DNA repair, inhibited; transcription, induced APE1(DISRUPTS) DNA(DISRUPTS) 11864601; 19966277 2 1 0 inhibits phosphorylation at other sites; histone acetylation +TSC2 TSC2 Cell cycle regulation; GAP; GAP, misc.; Nuclear receptor co-regulator; Tumor suppressor P49815 7249 16p13.3 human R1457-me 1877221602 PRSPSGLrPRGYTIS protein stabilization; phosphorylation signaling pathway regulation 33273660 1 0 0 mTOR activity; inhibits phosphorylation +Epor EPOR Membrane protein, integral; Receptor, cytokine Q07303 24336 8q13 rat Y455-p 455532 PPHLKYLyLVVSDSG signaling pathway regulation 25219375 8 0 0 promotes cell survival +MAPT Tau iso3 ACETYLTRANSFERASE; Acetyltransferase; Cytoskeletal P10636-3 4137 17q21.31 human S271-p 449081 GAEIVYKsPVVSGDT molecular association, regulation cytoskeletal reorganization 10747907 192 49 90 regulates association with membrane +CDCA8 Borealin Cell cycle regulation; Nucleolus Q53HL2 55143 1p34.3 human S219-p 460351 YNISGNGsPLADSKE Borealin protein degradation cell cycle regulation 20803554; 22383538 3 53 2 +PINK1 PINK1 EC 2.7.11.1; KINASE; Kinase, protein; Membrane protein, integral; Mitochondrial; Protein kinase, Other; Protein kinase, Ser/Thr (non-receptor) Q9BXM7 65018 1p36.12 human K137-ub 964535576 AIFTQKSkPGPDPLD protein degradation 28683321 1 2 0 +Ets2 Ets-2 DNA-binding; Oncoprotein; Transcription factor P15037 23872 16 C4|16 56.64 cM mouse T72-p 447688 SCELPLLtPCSKAVM activity, induced apoptosis, inhibited; transcription, induced; transcription, altered 11027273; 14612405; 15240733 9 0 0 Inflammation was attenuated in the Ets2 A72/A72 Hcph me-v/me-v mice +GAREM1 GAREM Adaptor/scaffold Q9H706 64762 18q12.1 human Y453-p 450613 PGKSELPyEELWLEE molecular association, regulation cell growth, altered GRB2(INDUCES); SHP-2(INDUCES) 19509291 1 18 96 +NFKBIA IkB-alpha DNA-binding; Inhibitor P25963 4792 14q13.2 human K22-sm 2798312 GPRDGLKkERLLDDR protein stabilization transcription, inhibited 17956732 1 0 0 inhibits NF-kB transcriptional activity +NANOG NANOG Cell development/differentiation; DNA-binding; Transcription factor Q9H9S0 79923 12p13.31 human Y174-p 25240300 QKASAPTyPSLYSSY activity, induced carcinogenesis, induced; cell motility, induced; cell growth, induced 22493428 1 0 0 increased lamellipodia and filopodia formation and increased cell polarization +CDC25A CDC25A EC 3.1.3.48; Motility/polarity/chemotaxis; PHOSPHATASE; Protein phosphatase, dual-specificity P30304 993 3p21.31 human S79-p 450247 QRMGSSEsTDSGFCL protein degradation; molecular association, regulation; ubiquitination; phosphorylation BTRC(INDUCES) 14681206; 19734889; 20348946 3 0 0 S76, S79, and S82 phosphorylation affect binding to BTRC; S79 phosphorylation by CK1-A primes for S82 phosphorylation by CK1-A; S79 phosphorylation is dependent on S76. +Atp5po ATP5O EC 3.6.3.14; Energy Metabolism - oxidative phosphorylation; Hydrolase; Mitochondrial Q9DB20 28080 16|16 C4 mouse K70-ac 467176 LRVGQLLkDPKVSLA OSCP activity, induced; molecular association, regulation PPID(INDUCES) 27489254 1 8 8 induce sensitization of opening of mitochondrial permeability transition pore +CEACAM1 CEACAM1 Cell adhesion; Immunoglobulin superfamily; Membrane protein, integral; Motility/polarity/chemotaxis P13688 634 19q13.2 human Y493-p 447777 NKMNEVTySTLNFEA molecular association, regulation ITGB3(INDUCES) 11485912 10 2 0 +DDC DDC Amino Acid Metabolism - histidine; Amino Acid Metabolism - phenylalanine; Amino Acid Metabolism - tryptophan; Amino Acid Metabolism - tyrosine; EC 4.1.1.28; Lyase; Nuclear receptor co-regulator P20711 1644 7p12.2-p12.1 human S193-p 1883995300 YSSDQAHsSVERAGL enzymatic activity, induced 37651872 1 0 0 +Prlr PRLR Membrane protein, integral; Receptor, cytokine P05710 24684 2q16 rat Y599-p 450273 LQLGRLDyLDPTCFM phosphorylation transcription, altered 7537382; 9516478 3 1 5 +IFI16 IFI16 Transcription factor Q16666 3428 1q23.1 human K4-ub 1877844702 ____MGKkYKNIVLL protein degradation signaling pathway regulation STING(INDUCES) 31665637 1 1 0 IFI16 degradation inhibits viral DNA-induced IFN-I production +LMNA lamin A/C Cytoskeletal P02545 4000 1q22 human S392-p 452606 ERLRLSPsPTSQRSR activity, induced; protein degradation; molecular association, regulation; intracellular localization cell cycle regulation 18815303; 24741066; 30190500; 7925482 11 105 85 dominant negative mitotic affects, and mitotic assembly and disassembly of lamin +Hist1h2ail1 H3 DNA-binding Q6LED0 291159 17p11 rat K4-m2 459004 ____ARTkQTARKST Histone transcription, induced 19476549 108 10 0 +Irs1 IRS1 Adaptor/scaffold; Motility/polarity/chemotaxis P35570 25467 9q34 rat S24-p 455604 GYLRKPKsMHKRFFV PH molecular association, regulation; intracellular localization cell growth, altered Other(DISRUPTS) 16574739 2 2 0 disrupts binding to PI(4,5)P2 in vitro +GPS1 COPS1 G protein regulator, misc. Q13098 2873 17q25.3 human S474-p 467704 KSPPREGsQGELTPA apoptosis, induced 26986008 1 58 84 UV induced apoptosis +Rbck1 RBCK1 EC 6.3.2.-; Ligase; UBIQUITIN LIGASE; Ubiquitin conjugating system; Ubiquitin ligase Q9WUB0 24105 2|2 G3 mouse T207-p 2103605 CTFINKPtRPGCEMC molecular association, regulation; protein conformation ubiquitin(DISRUPTS) 37595872 2 0 0 +MAPT Tau iso8 ACETYLTRANSFERASE; Acetyltransferase; Cytoskeletal P10636-8 4137 17q21.31 human S422-p 449083 GSIDMVDsPQLATLA O-GlcNAc glycosylation; molecular association, regulation; protein processing; phosphorylation cell growth, inhibited; cytoskeletal reorganization; transcription, inhibited Tau iso8(INDUCES); Tau(INDUCES) 15190058; 15664690; 16606369; 16923168; 19451179; 30734106; 33710538; 35857446 41 10 0 +VASP VASP Cytoskeletal; Motility/polarity/chemotaxis P50552 7408 19q13.32 human S157-p 448379 EHIERRVsNAGGPPA activity, induced; molecular association, regulation; intracellular localization; protein conformation carcinogenesis, induced; carcinogenesis, inhibited; cell motility, induced; cell motility, inhibited; cell adhesion, altered; cytoskeletal reorganization; transcription, inhibited; cell growth, altered VASP(INDUCES); Vinculin(INDUCES); SPTAN1(DISRUPTS); CRKL(DISRUPTS) 11919161; 14679200; 15178555; 18195108; 18637808; 20463151; 23846685; 25759389; 25961942; 26336132; 27620165; 33737052; 33755220; 37335130 55 4 0 +RB1 Rb Nuclear receptor co-regulator; Oncoprotein; Transcription, coactivator/corepressor; Tumor suppressor P06400 5925 13q14.2 human S811-p 448717 IYISPLKsPYKISEG Rb_C protein degradation; molecular association, regulation; ubiquitination; phosphorylation cell cycle regulation; carcinogenesis, induced; cell growth, induced; transcription, induced; transcription, altered; cell growth, altered ID2(DISRUPTS); E2F1(DISRUPTS); SETDB1(DISRUPTS); Abl iso2(DISRUPTS) 10969768; 15028555; 15619620; 16007177; 25698448; 32093423; 32094692; 33556114; 34108622; 34209868; 34247189; 35194151; 35235778; 35437308; 36603130; 36637424; 8626527; 9315635 96 40 80 +DGKA DGKA EC 2.7.1.107; Kinase, lipid; Lipid Metabolism - glycerolipid; Lipid Metabolism - glycerophospholipid; Motility/polarity/chemotaxis P20192 397097 pig Y217-p 22874703 KRFPRPVyCNLCESS C1_1 intracellular localization 22199356 1 0 2 necessary for serum-induced export from nucleus to cytoplasm +APOBEC1 APOBEC1 Cell cycle regulation; EC 3.5.4.-; Hydrolase; RNA processing; RNA-binding P41238 339 12p13.31 human S47-p 448433 YEIKWGMsRKIWRSS APOBEC4_like enzymatic activity, induced 11463337 1 0 0 +AR AR DNA-binding; Nuclear receptor; Transcription factor P10275 367 Xq12 human K619-ac 59149200 CPSCRLRkCYEAGMT zf-C4 molecular association, regulation; intracellular localization carcinogenesis, induced; cell growth, induced; transcription, induced HSP90A(DISRUPTS); POLR2A(INDUCES) DNA(INDUCES) 27659526 1 0 0 +KPNA4 KPNA4 Adaptor/scaffold; Chaperone; Karyopherin; Nuclear import O00629 3840 3q25.33 human S60-p 469763 HEDICEDsDIDGDYR IBB activity, induced; molecular association, regulation cell growth, induced; signaling pathway regulation RREB1(INDUCES) 31822798 1 39 6 Ras/ERK signaling +TPT1 TPT1 Calcium-binding; Microtubule-binding P13693 7178 13q14.13 human S46-p 476067 TEGNIDDsLIGGNAS TCTP protein degradation; molecular association, regulation; protein conformation carcinogenesis, inhibited; apoptosis, induced TPT1(INDUCES) 29719201; 34472703; 34675258 8 11 9 +XRCC6 Ku70 DNA repair, damage; DNA-binding; EC 3.6.4.-; EC 4.2.99.-; Helicase; Nuclear receptor co-regulator; RNA-binding P12956 2547 22q13.2 human Y530-p 463414 DEFKELVyPPDYNPE Ku_C apoptosis, inhibited 27998981 1 1 1 +SERPINF1 PEDF Inhibitor; Secreted; Secreted, signal peptide P36955 5176 17p13.3 human S114-p 455232 ALYYDLIsSPDIHGT Serpin molecular association, regulation apoptosis, altered; carcinogenesis, altered; cell motility, altered LEPR(INDUCES) 21059648 2 0 0 +HSPB6 HSP20 Chaperone; Heat shock protein O14558 126393 19q13.12 human S16-p 450706 PSWLRRAsAPLPGLS Crystallin molecular association, regulation; protein conformation apoptosis, inhibited; cell motility, inhibited; cytoskeletal reorganization 14-3-3 zeta(INDUCES) 15829720; 17084643; 18790732; 22731613; 22794279; 25446653; 27046040 21 31 2 +MAPT Tau iso8 ACETYLTRANSFERASE; Acetyltransferase; Cytoskeletal P10636-8 4137 17q21.31 human S235-p 449080 VVRTPPKsPSSAKSR molecular association, regulation; intracellular localization; phosphorylation cytoskeletal reorganization TUBA4A(DISRUPTS); Fyn(DISRUPTS); Tau iso8(INDUCES) 15190058; 16115884; 16687396; 20550628 45 36 25 regulates phosphorylation of tau S199 and S262; Phosphotylated sites found in the somato-dendritic campartment but not in the axon, where tau was not phosphorylated (T205 and T217), or not simultaneously phosphorylated (T231 and 235). +GLE1 GLE1 Karyopherin; Nuclear export Q53GS7 2733 9q34.11 human S88-p 12667856 QPSFVPKsPDASSAF molecular association, regulation GLE1(INDUCES) 30429220 1 13 2 self-association stress granules' assembly and disassembly, DDX3-ATPase activity inhibited +Mef2c MEF2C DNA-binding; Transcription factor Q8CFN5 17260 13 C3|13 43.68 cM mouse K4-ac 12718500 ____MGRkKIQITRI molecular association, regulation cell differentiation, induced; transcription, induced DNA(INDUCES) 18086704 1 1 0 +IRF3 IRF3 DNA-binding; Transcription factor Q14653 3661 19q13.33 human S173-p 6370303 PCPQPLRsPSLDNPT molecular association, regulation; phosphorylation transcription, inhibited; transcription, altered IRF7(INDUCES) 19153595; 23685991; 24275658 6 8 0 Formation of IRF3:IRF7 dimers +SREBF2 SREBP-2 DNA-binding; Membrane protein, integral; Membrane protein, multi-pass; Transcription factor Q12772 6721 22q13.2 human S455-p 451008 SIDSEPGsPLLDDAK sumoylation transcription, induced 14988395; 18403372 2 0 0 inhibits sumoylation, leading to enhanced transcriptional activation +Foxo1 FOXO1A DNA-binding; Nuclear receptor co-regulator; Oncoprotein; Transcription factor Q9R1E0 56458 3 C|3 23.19 cM mouse S295-p 471972 QFSKWPAsPGSHSND molecular association, regulation; intracellular localization transcription, inhibited DUSP6(INDUCES) 22503562; 22848439 6 12 30 +Neto2 NETO2 Adaptor/scaffold; Membrane protein, integral C6K2K4 307757 rat S409-p 4752528 SLREKEIsADLADLS neural plasticity 28717010 1 4 1 synaptic targeting of GluK1 is inhibited +DVL3 DVL3 Motility/polarity/chemotaxis Q92997 1857 3q27.1 human S280-p 34668101 DGGIYIGsIMKGGAV PDZ activity, induced; intracellular localization transcription, induced 24993822; 27486244 2 2 0 +OSMR OSMR Membrane protein, integral; Receptor, cytokine Q99650 9180 5p13.1 human Y945-p 1930202 EAPHCSEyKMQMAVS phosphorylation 18430728 2 0 0 important for STAT3 activation +PCK1 PCK1 Carbohydrate Metabolism - citrate (TCA) cycle; Carbohydrate Metabolism - glycolysis and gluconeogenesis; Carbohydrate Metabolism - pyruvate; EC 4.1.1.32; KINASE; Kinase, other; Lyase; Protein kinase, Ser/Thr (non-receptor) P35558 5105 20q13.31 human K91-ac 1880915300 DVARIESkTVIVTQE enzymatic activity, induced 30193097 1 1 0 +ATF2 ATF-2 ACETYLTRANSFERASE; C2H2-type zinc finger protein; EC 2.3.1.48; Transcription factor P15336 1386 2q31.1 human K374-ac 1910101 SRCRQKRkVWVQSLE bZIP_1 transcription, induced 17590016 1 1 0 +ROCK2 ROCK2 EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, AGC; Protein kinase, Ser/Thr (non-receptor) Q28021 282041 cow S1099-p 1732202 QAQIAEEsQIRIELQ enzymatic activity, induced cell cycle regulation 17446864 1 0 0 alanine mutation of all 4 sites +Eef1a1 EEF1A1 Nucleolus; Translation; Translation elongation P10126 13627 9|9 E1 mouse K165-m2 3898709 TEPPYSQkRYEEIVK GTP_EFTU molecular association, regulation translation, altered EEF1D(DISRUPTS); eEF1B(DISRUPTS); EEF1G(DISRUPTS) 28108655 1 7 12 +SIRT1 SIRT1 Apoptosis; DEACETYLASE; Deacetylase; EC 3.5.1.-; Nuclear receptor co-regulator Q96EB6 23411 10q21.3 human S540-p 4770118 HVSEDSSsPERTSPP acetylation; intracellular localization; enzymatic activity, induced cell cycle regulation; cytoskeletal reorganization 19107194; 30517871 2 5 4 suppress centriole duplication +Hmga1 HMGA1 DNA-binding Q8K585 117062 20p12 rat S64-p 3136103 PRGRPKGsKNKGTAK molecular association, regulation DNA(DISRUPTS) 10617144 1 1 0 +MLXIPL ChREBP Transcription factor Q9NP71 51085 7q11.23 human S140-p 2103610 QYVKRRKsPVCGFVT molecular association, regulation; intracellular localization 14-3-3 beta(INDUCES); KPNA2(DISRUPTS) 23918932 3 1 0 regulates lipogenesis +Sp7 osterix C2H2-type zinc finger protein; DNA-binding; Transcription factor Q8VI67 170574 15|15 F3 mouse K386-ub 40477507 GPPPSGPkELGEGRS protein degradation cell differentiation, inhibited; transcription, induced 25818514 1 0 0 inhibits BMP signaling +PHGDH PHGDH Amino Acid Metabolism - glycine, serine and threonine; Cell development/differentiation; EC 1.1.1.95; Oxidoreductase O43175 26227 1p12 human K146-ub 12338481 MGTELNGkTLGILGL 2-Hacid_dh; 2-Hacid_dh_C enzymatic activity, induced cell motility, induced; cell adhesion, induced; transcription, induced 34720086 2 6 4 SETD1A-mediated increase H3K9m3, increasing cell adhesion gene transcription and promoting CRC metastasis; expressions of cell adhesion genes LAMC2 and CYR61 +GBF1 GBF1 GEF; GEF, ARF Q92538 8729 10q24.32 human S292-p 1170755600 VVSPSTDsGLEFSSQ protein degradation; molecular association, regulation; ubiquitination; intracellular localization cell cycle regulation; cytoskeletal reorganization BTRC(INDUCES) 29898406 1 1 0 +CEP250 CEP250 Cell cycle regulation Q9BV73 11190 20q11.22 human S2394-p 4728460 LHHSLSHsLLAVAQA cell cycle regulation 20708153 1 2 0 +CA9 CA9 EC 4.2.1.1; Energy Metabolism - nitrogen; Lyase; Membrane protein, integral; Nucleolus Q16790 768 9p13.3 human S448-p 3197489 RGTKGGVsYRPAEVA molecular association, regulation; enzymatic activity, inhibited MMP14(INDUCES) 22037869; 28692057 2 5 0 +HDAC4 HDAC4 DEACETYLASE; Deacetylase; EC 3.5.1.98; Hydrolase; Nuclear receptor co-regulator; SUMO LIGASE P56524 9759 2q37.3 human S350-p 14314314 LPLYTSPsLPNITLG molecular association, regulation 14-3-3 gamma(INDUCES); ANKRA2(DISRUPTS) 22649097 1 4 2 a phospho-controlled switch alternating association ANKRA2 and 14-3-3 gamma +Klf1 KLF1 C2H2-type zinc finger protein; DNA-binding; Transcription factor P46099 16596 8 41.3 cM|8 C3 mouse K56-sm 2798306 PSLHVSLkSEDPSGE sumoylation; molecular association, regulation; intracellular localization cell differentiation, inhibited; carcinogenesis, inhibited; transcription, inhibited KPNB1(INDUCES); CHD-4(INDUCES) 17938210; 24576425; 35822667 3 0 0 KLF1(K54R) knockin delays the onset of age-related disorders, knockin HSCs potentiate antiaging and lifespan extension, suppresses tumor metastasis and tumorigenesis in vivo +RPTOR Raptor Adaptor/scaffold Q8N122 57521 17q25.3 human S722-p 2314601 PRLRSVSsYGNIRAV cell cycle regulation; autophagy, induced; transcription, altered 21900751; 34604061 9 52 7 +Naca NACA iso2 Motility/polarity/chemotaxis; Transcription, coactivator/corepressor Q60817 17938 10|10 D3 mouse S132-p 471099 EAKIEDLsQQAQLAA molecular association, regulation transcription, inhibited TXLNG(INDUCES); HDAC2(INDUCES) 24375853 1 5 18 +DTD1 DTD1 DNA replication; EC 3.1.-.-; Hydrolase Q8TEA8 92675 20p11.23 human S182-p 36396301 AKGPSESsKERNTPR molecular association, regulation cell cycle regulation; cell growth, induced MCM7(INDUCES); MCM3(DISRUPTS) 25258324 1 0 0 decreases DTD1 incorporation into HMW, supports DNA replication initiation +ZNF148 ZNF148 C2H2-type zinc finger protein; DNA-binding; Transcription, coactivator/corepressor Q9UQR1 7707 3q21.2 human K115-sm 2798308 LNVPISVkQEITFTD transcription, inhibited 17940278 1 1 0 +TNNI3 TNNI3 Actin-binding; Motility/polarity/chemotaxis; Motor P19429 7137 19q13.42 human S24-p 448424 APIRRRSsNYRAYAT Troponin-I_N activity, induced; molecular association, regulation; activity, inhibited cytoskeletal reorganization TNNC1(DISRUPTS) 15134451; 24116014; 24585778; 27557662; 28018230; 8543035 64 12 16 increased myofilament length ; muscle contraction +Slc15a2 SLC15A2 Membrane protein, integral; Membrane protein, multi-pass; Transporter; Transporter, SLC family Q9ES07 57738 16|16 B3 mouse K139-sm 1881396700 AIPILGGkMLHTILS intracellular localization 34881291 1 1 0 localized to the apical membrane of DCT cells +SUFU SUFU Adaptor/scaffold; Transcription, coactivator/corepressor; Tumor suppressor Q9UMX1 51684 10q24.32 human S346-p 4786848 RAPSRKDsLESDSST SUFU_C molecular association, regulation; protein stabilization; intracellular localization; phosphorylation FBXL17(DISRUPTS) 21317289; 27234298 4 30 3 +Thrap3 Trap150 RNA-binding; Transcription, coactivator/corepressor Q569Z6 230753 4|4 D2.2 mouse S243-p 452511 RASVSDLsPRERSPA THRAP3_BCLAF1 molecular association, regulation PPAR-gamma(INDUCES) 34526909 1 114 33 +Rps6kb2 P70S6KB EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, AGC; Protein kinase, Ser/Thr (non-receptor); Translation Q9Z1M4 58988 19|19 A mouse T420-p 468357 RLNSSPRtPISPLKF phosphorylation 17980619 1 5 3 +KAT2B PCAF ACETYLTRANSFERASE; Acetyltransferase; EC 2.3.1.48; Nuclear receptor co-regulator Q92831 8850 3p24.3 human K416-ac 458984 GSSSPACkASSGLEA enzymatic activity, induced 12888487 1 0 0 in vitro +PRMT5 PRMT5 Cell cycle regulation; EC 2.1.1.125; METHYLTRANSFERASE; Methyltransferase; Methyltransferase, protein arginine; RNA processing O14744 10419 14q11.2 human Y324-p 1869973804 DNLESQTyEVFEKDP PRMT5 protein degradation; molecular association, regulation; methylation; enzymatic activity, inhibited; phosphorylation apoptosis, induced; DNA repair, inhibited Other(DISRUPTS) 32759981 1 0 0 inhibits methylation further inducing degradation of 53BP1, induces dephosphorylation of H2AX, inhibits binding to S-adenosyl methionine +Ppp2r5b PPP2R5B Motility/polarity/chemotaxis; Protein phosphatase, regulatory subunit Q6PD28 225849 19|19 A mouse S35-p 10405458 VDGFSRRsLRRARPR molecular association, regulation; phosphorylation PPP2CA(INDUCES); PPP2R5B(INDUCES) 21329884 1 0 1 PPP2R2R5B phosphorylation by CLK2 is required for the PPP2CA-AKT complex; induces AKT dephosphorylation +CALD1 Caldesmon Actin-binding Q05682 800 7q33 human S789-p 448466 QSVDKVTsPTKV___ intracellular localization cell motility, altered; cytoskeletal reorganization 16289153; 17562849; 20128924 19 19 0 +Rorc RORC iso2 DNA-binding; Nuclear receptor; Transcription factor P51450-2 19885 3|3 F2.1 mouse K256-ub 41494427 YLVQNVCkSFRETCQ molecular association, regulation transcription, induced; signaling pathway regulation DNA(INDUCES) 36269826 1 1 0 RORC-K256R impairs the signaling pathway for the pathogenesis of EAE but not for the TH17 differentiation; K256 fails to bind to and activate Runx1 expression critical for TH17-mediated EAE +Gja1 GJA1 Channel, misc.; Membrane protein, integral; Membrane protein, multi-pass; Motility/polarity/chemotaxis P23242 14609 10 B4|10 28.64 cM mouse S255-p 448852 HATTGPLsPSKDCGS protein degradation; ubiquitination endocytosis, induced 24612377 23 21 1 +Pde4d PDE4D iso6 EC 3.1.4.53; Nucleotide Metabolism - purine; Phosphodiesterase P14270-6 24627 rat S81-p 33670300 KSMSRNSsIASDIHG cell cycle regulation 24815749 1 0 0 +STAT1 STAT1 DNA-binding; Transcription factor P42224 6772 2q32.2 human Y701-p 447754 DGPKGTGyIKTELIS activity, induced; protein degradation; sumoylation; molecular association, regulation; intracellular localization; protein conformation cell cycle regulation; carcinogenesis, induced; carcinogenesis, inhibited; cell growth, inhibited; transcription, induced; signaling pathway regulation; transcription, altered; cell differentiation, altered; apoptosis, inhibited; transcription, inhibited; cell growth, altered STAT2(INDUCES); PIAS1(INDUCES); STAT1(INDUCES); DUX4(INDUCES) DNA(INDUCES); DNA(DISRUPTS) 10921891; 11023524; 11316742; 11777927; 11823427; 12637327; 12807916; 14962955; 15051500; 15767445; 15994321; 17442890; 18566411; 19088846; 19174562; 23043228; 24882218; 25921060; 33472080; 34233951; 34358560; 34379505; 35154579; 35196494; 35361236; 35568036; 35705809; 36166512; 36203966; 36288705; 37092726; 8197134; 9724754 204 7 64 PIAS1 inhibits DNA binding activity of STAT1. +FBXW7 FBXW7 Motility/polarity/chemotaxis; Nucleolus; UBIQUITIN LIGASE; Ubiquitin conjugating system; Ubiquitin ligase Q969H0 55294 4q31.3 human S25-p 25126710 SLRGNPSsSQVDEEQ protein degradation cytoskeletal reorganization 22399798 1 1 0 Phosphorylation prevents ubiquitin-dependent degradation of cyclin E and subsequent centriole duplication. +KAT2B PCAF ACETYLTRANSFERASE; Acetyltransferase; EC 2.3.1.48; Nuclear receptor co-regulator Q92831 8850 3p24.3 human K720-ac 1876931100 PSGKEKSkEPRDPDQ molecular association, regulation cell cycle regulation MDM2(DISRUPTS) 32404984 1 0 0 +RRM2 RRM2 EC 1.17.4.1; Nucleotide Metabolism - purine; Nucleotide Metabolism - pyrimidine; Other Amino Acids Metabolism - glutathione; Oxidoreductase P31350 6241 2p25.1 human Y221-p 464201 IGDKEATyGERVVAF Ribonuc_red_sm enzymatic activity, induced 20484015 1 0 1 +Psmc5 RPT6 Nuclear receptor co-regulator; Proteasome complex; Ubiquitin conjugating system P62198 81827 10q32.1 rat S120-p 483970 RVALRNDsYTLHKIL Prot_ATP_ID_OB protein degradation; activity, inhibited; phosphorylation neural plasticity; cytoskeletal reorganization; transcription, inhibited; signaling pathway regulation 22496558; 22726833; 24009566; 35842713 11 7 0 inhibits IKB phosphorylation and the NF-kB signalling pathway; proteasome-dependent dendritic spine growth; memory +KIF11 KIF11 Microtubule-binding; Motor P52732 3832 10q23.33 human Y125-p 4251398 ERSPNEEyTWEEDPL Kinesin cytoskeletal reorganization 28646493 1 3 9 spindle morphology +Rfc1 RFC1 DNA replication D3ZFT1 89809 14p11 rat S245-p 468617 TKKARKDsEEGESFS transcription, induced 10625661 1 25 12 +ABL1 Abl EC 2.7.10.2; KINASE; Kinase, protein; Oncoprotein; Protein kinase, TK; Protein kinase, tyrosine (non-receptor) P00519 25 9q34.12 human S618-p 1779804 APTPPKRsSSFREMD molecular association, regulation; phosphorylation; enzymatic activity, induced Abi-2(DISRUPTS) 18161990 1 2 0 interaction in vitro and in vivo; phosphorylation of this site enhances the association and phosphorylation of the Abl substrate, Crk. +Nr2c2 NR2C2 DNA-binding; Nuclear receptor; Transcription factor P49117 22026 6|6 D1 mouse S351-p 7990482 HVISRDQsTPIIEVE intracellular localization transcription, inhibited; signaling pathway regulation 21478464 1 3 0 supress SCD1 gene expression, regulates lipid metabolism through the metformin-AMPK-TR4-SCD1 pathway +C5AR2 C5AR2 GPCR, family 1; Membrane protein, integral; Membrane protein, multi-pass; Receptor, GPCR Q9P296 27202 19q13.32 human S323-p 9819900 GQDESVDsKKSTSHD activity, induced; receptor internalization, altered; intracellular localization 19615750 1 0 0 +Sod2 SOD2 EC 1.15.1.1; Mitochondrial; Oxidoreductase P09671 20656 17 A1|17 8.75 cM mouse K68-ac 461133 NLNATEEkYHEALAK Sod_Fe_N intracellular localization; enzymatic activity, inhibited; protein conformation; enzymatic activity, altered cell cycle regulation; autophagy, induced; cell differentiation, induced; cytoskeletal reorganization 25529796; 25790176; 28369333; 28433661; 28914882; 33680286 23 13 8 mediates pentameric SOD2 deaggregation; regulates meiotic and spindle defects, induces accumulation of reactive oxygen species; induces ROS production, PARK recruitment to mitochondria and mitophagy; increased hyperglycemia-induced renal damage; SIRT3 deacetylating SOD2 at K68 contributes to differentiation +NFKB2 NFkB-p100 DNA-binding; Oncoprotein; Transcription factor Q00653 4791 10q24.32 human S866-p 450166 TAEVKEDsAYGSQSV molecular association, regulation; protein processing IKKA(INDUCES); BTRC(INDUCES) 11239468; 15310758; 22388891 7 1 0 +SMC3 SMC3 Cell cycle regulation; DNA repair, damage Q9UQE7 9126 10q25.2 human K106-ac 461825 RRVIGAKkDQYFLDK SMC_N protein stabilization; molecular association, regulation cell cycle regulation; DNA repair, induced; chromatin organization, altered; cell growth, induced; cytoskeletal reorganization DNA(INDUCES) 18614053; 20501661; 22101327; 22751501; 28847955; 29196537 7 10 173 regulates mitotic chromosome segregation and sister chromatid cohesion, ESCO2 KO has growth defects; Sister chromatid cohesion +MACF1 ACF7 Actin-binding; Cytoskeletal; Motility/polarity/chemotaxis Q9UPN3 23499 1p34.3 human S7310-p 18507009 ADPKKSAsRPGSRAG intracellular localization cell motility, induced; cytoskeletal reorganization 21295697 1 1 0 inhibits localization along microtubules, alters organization of microtubules, regulates skin wound repair, SC migration +Gab2 GAB2 Adaptor/scaffold Q9Z1S8 14389 7|7 E1 mouse S211-p 4825112 TENARSAsFSQGTRQ molecular association, regulation; phosphorylation cell motility, inhibited; signaling pathway regulation SHP-2(DISRUPTS) 23401857; 26060331 3 19 8 inhibits ERK1/2 phosphorylation, modulates Ras/MAPK signaling pathway; enhances insulin-induced Akt signaling; suppresses EGF-induced Akt signaling +Brsk2 BRSK2 EC 2.7.11.1; EC 2.7.11.26; KINASE; Kinase, protein; Protein kinase, CAMK; Protein kinase, Ser/Thr (non-receptor) Q69Z98 75770 7|7 F5 mouse S467-p 4734917 TPNPTPPsSPSVGGV protein stabilization; enzymatic activity, inhibited; phosphorylation 23790753 1 0 2 inhibits axon branching (activated in BRSK2 18A mutant) +SMN1 SMN RNA processing; RNA-binding Q16637 6606 5q13.2 human T25-p 484165 SVLFRRGtGQSDDSD molecular association, regulation; intracellular localization coilin(INDUCES) 24602413 1 40 17 +Tfe3 TFE3 DNA-binding; Oncoprotein; Transcription factor Q64092 209446 X A1.1|X 3.5 cM mouse S565-p 455896 KASSRRSsFSMEEES DUF3371 intracellular localization autophagy, inhibited 30324847 1 19 8 maintains cytoplasmic localization +PKMYT1 Myt1 EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, Other; Protein kinase, Ser/Thr (non-receptor); Protein kinase, dual-specificity (non-receptor) Q99640 9088 16p13.3 human T455-p 11331003 RTVGSTStPRSRCTP molecular association, regulation PIN1(INDUCES) 10504341 1 1 7 +Creb1 CREB iso1 DNA-binding; Transcription factor P15337-1 81646 9q32 rat K91-ac 459097 QTVQSSCkDLKRLFS transcription, inhibited 12595525 1 0 0 modulating CREB-mediated gene expression +FPR2 FPR2 GPCR, family 1; Membrane protein, integral; Membrane protein, multi-pass; Motility/polarity/chemotaxis; Receptor, GPCR P25090 2358 19q13.41 human T332-p 19075300 LSEDSAPtNDTAANS receptor desensitization, induced; phosphorylation 21543323 1 0 0 +Mlxipl ChREBP Transcription factor Q99MZ3 58805 5|5 G2 mouse T517-gl 89115103 GQKASPPtLASATAS transcription, induced 28450420 1 0 0 S514 phosphorylation could enhance ChREBP O-GlcNAcylation +NFE2 NF-E2 Cytoskeletal; DNA-binding; Transcription factor Q16621 4778 12q13.13 human S157-p 11489902 LNYSDAEsLELEGTE protein degradation; ubiquitination transcription, inhibited 19966288 1 1 0 +Rasgrf1 RASGRF1 GEF; GEF, Ras P28818 192213 8q31 rat S854-p 18710204 FPLFNYNsGIMMTCR protein degradation 21382555 1 1 0 +TCAP Telethonin Motility/polarity/chemotaxis O15273 8557 17q12 human S161-p 3893741 RSLSRSMsQEAQRG_ Telethonin protein degradation; ubiquitination cytoskeletal reorganization 24280220; 32937135 3 8 3 affects synchronous release and removal of Ca2 as a consequence of altered t-tubule organization +PDGFRA PDGFRA EC 2.7.10.1; KINASE; Kinase, protein; Membrane protein, integral; Oncoprotein; Protein kinase, TK; Protein kinase, tyrosine (receptor) P16234 5156 4q12 human Y574-p 448438 PDGHEYIyVDPMQLP molecular association, regulation Src(INDUCES) 9454734 2 3 15 +Kcnj1 ROMK iso2 Channel, potassium; Membrane protein, integral; Membrane protein, multi-pass P35560-2 rat S25-p 449605 RQRARLVsKEGRCNI IRK activity, induced 8621594 9 0 0 phosphorylation of at least two serines necessary for channel activity +FOXG1 FOXG1 DNA-binding; Nuclear receptor co-regulator; Transcription factor P55316 2290 14q12 human S19-p 482880 MIPKSSFsINSLVPE intracellular localization cell differentiation, altered 17435750 1 0 0 +CETN1 CETN1 Q12798 1068 18p11.32 human S170-p 1430241100 LRIMKKTsLY_____ molecular association, regulation; protein conformation SFI1(DISRUPTS) 30682474 1 0 0 +EEF1A1 EEF1A1 Nucleolus; Translation; Translation elongation P68104 1915 6q13 human K165-m3 15382301 TEPPYSQkRYEEIVK GTP_EFTU molecular association, regulation translation, altered EEF1D(DISRUPTS); eEF1B(DISRUPTS); EEF1G(DISRUPTS) 28108655 1 3 3 +PDGFRB PDGFRB EC 2.7.10.1; KINASE; Kinase, protein; Membrane protein, integral; Oncoprotein; Protein kinase, TK; Protein kinase, tyrosine (receptor) P09619 5159 5q32 human S1104-p 454229 PRAEAEDsFL_____ molecular association, regulation; receptor desensitization, altered NHERF(DISRUPTS) 15271984 1 0 0 +PIN1 PIN1 EC 5.2.1.8; Isomerase; Nuclear receptor co-regulator Q13526 5300 19p13.2 human K63-sm 31094509 RCSHLLVkHSQSRRP Rotamase protein degradation; enzymatic activity, inhibited carcinogenesis, inhibited; cell growth, inhibited; transcription, inhibited 23633483 1 0 0 inhibits cyclin D1 stability +TACSTD2 TACSTD2 Membrane protein, integral; Receptor, misc. P09758 4070 1p32.1 human S303-p 451171 VITNRRKsGKYKKVE protein conformation; phosphorylation carcinogenesis, induced; cell growth, induced; cytoskeletal reorganization 25981199; 35132180 2 1 0 +EGFR EGFR EC 2.7.10.1; KINASE; Kinase, protein; Membrane protein, integral; Oncoprotein; Protein kinase, TK; Protein kinase, tyrosine (receptor) P00533 1956 7p11.2 human Y1069-p 448056 EDSFLQRySSDPTGA activity, induced; protein degradation; molecular association, regulation; ubiquitination carcinogenesis, induced; carcinogenesis, inhibited; cell motility, induced CBL(INDUCES) 12631709; 14627991; 16729043; 20215522; 21787862; 33657368; 35197444; 37085908 45 18 117 +Parp2 PARP2 DNA repair, damage; EC 2.4.2.30; Transferase O88554 11546 14 26.25 cM|14 C1 mouse K36-ac 2459112 EDDSPPGkKMRTCQR molecular association, regulation; intracellular localization; enzymatic activity, inhibited DNA(DISRUPTS) 18436469 1 0 3 +Rps6kb1 p70S6K EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, AGC; Protein kinase, Ser/Thr (non-receptor); Translation P67999 83840 10q26 rat S452-p 471897 PVSPVKFsPGDFWGR enzymatic activity, induced 11705993 2 23 76 Quadruple mutant was 20% protected from inactivation by glucocorticoids. +INPPL1 SHIP-2 Carbohydrate Metabolism - inositol phosphate; EC 3.1.3.86; Motility/polarity/chemotaxis; Phosphatase, lipid O15357 3636 11q13.4 human T958-p 475076 APREEPLtPRLKPEG phosphorylation 17219406 1 4 12 Tyrosine phosphorylation is regulated by T958. +Syngap1 SynGAP iso3 GAP; GAP, Ras Q9QUH6-3 192117 20p12 rat S777-p 18710208 EPEQKMLsVNKSVSM DUF3498 molecular association, regulation; intracellular localization HRas(INDUCES) 21382555 1 2 0 +VAMP8 VAMP8 Membrane protein, integral; Vesicle Q9BV40 8673 2p11.2 human T48-p 472548 LEHLRNKtEDLEATS Synaptobrevin activity, inhibited 27402227 1 9 39 abolish function in SNARE complex during mast cell secretion, reduces in vitro ensemble vesicle fusion +BACH2 BACH2 DNA-binding; Transcription factor Q9BYV9 60468 6q15 human S521-p 470117 ETRTRTSsSCSSYSY intracellular localization apoptosis, inhibited; transcription, altered; cell growth, altered 17018862 2 1 0 regulates transcription of HO-1 +DCBLD2 DCBLD2 Cell adhesion; Membrane protein, integral Q96PD2 131566 3q12.1|3 human Y750-p 454600 PAPDELVyQVPQSTQ molecular association, regulation CRKL(INDUCES) 23770091 2 22 204 +LTA4H LTA4H EC 3.3.2.6; Hydrolase; Lipid Metabolism - arachidonic acid P09960 4048 12q23.1 human S416-p 451021 KAYVEKFsYKSITTD Peptidase_M1 enzymatic activity, inhibited 9395533 1 0 0 This phosphorylation and consequent enzymatic activity inhibition have not been observed in lung carcinoma cell line +FLT3 FLT3 EC 2.7.10.1; KINASE; Kinase, protein; Membrane protein, integral; Oncoprotein; Protein kinase, TK; Protein kinase, tyrosine (receptor) P36888 2322 13q12.2 human Y955-p 454873 ADAEEAMyQNVDGRV molecular association, regulation; phosphorylation cell cycle regulation GRB2(INDUCES); Fyn(INDUCES) 16627759; 19438505; 26848862 5 1 15 regulates cell proliferation +Pde4d PDE4D iso6 EC 3.1.4.53; Nucleotide Metabolism - purine; Phosphodiesterase P14270-6 24627 rat S245-p 469621 KKLMHSSsLTNSCIP cell cycle regulation 24815749 2 12 6 +SRSF1 SF2 RNA splicing; RNA-binding; Spliceosome Q07955 6426 17q22 human Y19-p 474154 GNNDCRIyVGNLPPD RRM_1 intracellular localization cell cycle regulation; carcinogenesis, induced; cell growth, induced 30320932 1 2 1 promotes cell proliferation, enhance cell cycle progression +ANTXR2 ANTXR2 Membrane protein, integral; Receptor, misc. P58335 118429 4q21.21 human Y445-p 13320001 QPPQTKWyTPIKGRL Ant_C ubiquitination 20080640 1 0 0 +AHR AHR DNA-binding; Transcription factor P35869 196 7p21.1 human S723-p 1874101928 ELDYPMGsFEPSPYP protein degradation; ubiquitination autophagy, induced; transcription, induced 34198826 1 0 0 +APP APP Apoptosis; Cell surface; Membrane protein, integral; Receptor, misc.; Transcription factor P05067 351 21q21.3 human K132-ac 1880082601 DALLVPDkCKFLHQE intracellular localization 35830807 1 1 0 AK7 ameliorates cognitive deficits in APP/PS1 mice via inhibition of K132/134 acetylation; APP acetylation is neuroprotective in cultured hippocampal neurons; APP localization at the cell surface +CHEK2 Chk2 EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, CAMK; Protein kinase, Ser/Thr (non-receptor); Tumor suppressor O96017 11200 22q12.1 human T517-p 981403 QVLAQPStSRKRPRE intracellular localization 17698850 1 1 0 found in nucleus and chromatin upon exposure with Tax +Erbb3 HER3 EC 2.7.10.1; KINASE; Kinase, protein; Membrane protein, integral; Oncoprotein; Protein kinase, TK; Protein kinase, tyrosine (receptor) Q62799 29496 7q11 rat Y1194-p 448640 EEDEDEEyEYMNRKR molecular association, regulation; phosphorylation PIK3CB(INDUCES); PIK3R1(INDUCES) 11546794 7 3 24 induces phosphorylation of Akt1. +NEK2 NEK2 EC 2.7.11.1; KINASE; Kinase, protein; Nucleolus; Protein kinase, Other; Protein kinase, Ser/Thr (non-receptor) P51955 4751 1q32.3 human S241-p 12574600 RRIPYRYsDELNEII Pkinase enzymatic activity, inhibited 17197699 1 1 0 +Ctnnd2 CTNND2 Actin-binding; Motility/polarity/chemotaxis O35927 18163 15|15 B2 mouse T454-p 480958 TGTFRTStAPSSPGV molecular association, regulation cytoskeletal reorganization RGNEF(INDUCES) 17993462 2 2 0 regulates dendrite formation in hippocampal neurons; interaction with CTNND2 prevents RGNEF from interacting with and activating RhoA. +PIK3C3 PIK3C3 Autophagy; Carbohydrate Metabolism - inositol phosphate; EC 2.7.1.137; Kinase, lipid; Motility/polarity/chemotaxis Q8NEB9 5289 18q12.3 human K771-ac 280006400 YILGRDPkPLPPPMK PI3_PI4_kinase enzymatic activity, inhibited autophagy, inhibited 28844862 1 1 0 nutrient starvation-induced autophagy +Mrtfa MKL1 Oncoprotein; Transcription, coactivator/corepressor Q8K4J6 223701 15|15 E1 mouse S492-p 467355 TGSTPPVsPTPSERS transcription, induced 33171330 3 44 15 regulates the expression of IL-6; regulates re-endothelialization +DBI DBI Lipid-binding P07108 1622 2q14.2 human S21-p 1880114700 RHLKTKPsDEEMLFI molecular association, regulation autophagy, induced Other(DISRUPTS) 36280213 1 0 0 inhibits binding to phosphatidylethanolamine +PACSIN1 PACSIN1 Adaptor/scaffold Q9BY11 29993 6p21.31 human S346-p 4730476 SQAGDRGsVSSYDRG molecular association, regulation PICK1(DISRUPTS) 23918399 2 3 0 regulates AMPAR trafficking +LASP1 Lasp-1 Actin-binding; Motility/polarity/chemotaxis O77506 100009568 rabbit S146-p 448836 AEPERRDsQDSSNYR intracellular localization cytoskeletal reorganization 12432067 6 33 135 +Oprm1 MOR-1 GPCR, family 1; Membrane protein, integral; Membrane protein, multi-pass; Receptor, GPCR P33535 25601 1q11 rat T180-p 448127 VKALDFRtPRNAKIV 7tm_1 receptor desensitization, altered MOR-1(NOT_REPORTED) 11060299; 14978231 3 0 0 Mutagenesis indicates T180 is required for receptor uncoupling, but phosphorylation of site has not been directly demonstrated. +LTB4R LTB4R GPCR, family 1; Membrane protein, integral; Membrane protein, multi-pass; Receptor, GPCR Q15722 1241 14q12 human S313-p 25608200 EGTGSEAsSTRRGGS receptor internalization, induced; phosphorylation signaling pathway regulation 22707565; 30131369 2 0 0 phosphorylation of LTB4R basal phosphorylation site; enhanced ligand-induced internalization ; chemotaxis, B-hexisaminidase release, regulates LTB4R function +RCC1 RCC1 Cell cycle regulation; GEF; GEF, Ras P18754 1104 1p35.3 human T32-p 2850001 VSHRSHStEPGLVLT molecular association, regulation KPNA4(DISRUPTS) 18568422 1 0 0 +MAPK3 ERK1 EC 2.7.11.24; KINASE; Kinase, protein; Protein kinase, CMGC; Protein kinase, Ser/Thr (non-receptor) P27361 5595 16p11.2 human K302-m3 52477002 LFPKSDSkALDLLDR Pkinase enzymatic activity, induced transcription, induced 26586479 1 1 0 SUV420H1 siRNA inhibits ERK expression +CHCHD3 CHCHD3 Mitochondrial Q9NX63 54927 7q32.3-q33 human T11-p 4038300 TTSTRRVtFEADENE intracellular localization 27153535 2 1 0 Parkin recruitment to mitochondria was negatively regulated by PKA-mediated phosphorylation of S528 of MIC60 and T11 of MIC19 +EIF2B5 eIF2B-epsilon Translation; Translation initiation Q13144 8893 3q27.1 human S544-p 449906 EPDSRGGsPQMDDIK signaling pathway regulation; translation, inhibited 22231169 5 77 9 +RBX1 RBX1 EC 6.3.2.-; Ligase; UBIQUITIN LIGASE; Ubiquitin conjugating system; Ubiquitin ligase P62877 9978 22q13.2 human Y106-p 25180501 REWEFQKyGH_____ intracellular localization 22448038 1 0 0 +Prkcb PKCB EC 2.7.11.13; KINASE; Kinase, protein; Motility/polarity/chemotaxis; Protein kinase, AGC; Protein kinase, Ser/Thr (non-receptor) P68403 25023 1q36 rat T642-p 447897 TRQPVELtPTDKLFI Pkinase_C intracellular localization; protein conformation; enzymatic activity, induced transcription, altered 21215369; 8034726; 8327493 14 14 0 increases expression of c-Fos and c-Jun +SOD1 SOD1 Apoptosis; EC 1.15.1.1; Mitochondrial; Nuclear receptor co-regulator; Oxidoreductase P00441 6647 21q22.11 human K76-sm 9184300 SRKHGGPkDEERHVG Sod_Cu protein stabilization 16828461 1 0 0 induces SOD1 aggregation +SHARPIN SHARPIN Apoptosis Q9H0F6 81858 8q24.3 human S146-p 31883820 ACPVSLPsPPEASTL molecular association, regulation carcinogenesis, induced; cell motility, induced ARP2(INDUCES) 36148554 1 4 0 +GABBR1 GABBR1 GPCR, family 3; Membrane protein, integral; Membrane protein, multi-pass; Receptor, GPCR Q9UBS5 2550 6p22.1 human K893-ub 7251351 EKSRLLEkENRELEK protein degradation; ubiquitination 26817839 2 1 2 +CLEC12B CLEC12B Membrane protein, integral; Receptor, misc. Q2HXU8 387837 12p13.2 human Y7-p 12518700 _MSEEVTyATLTFQD molecular association, regulation; activity, inhibited SHP-2(INDUCES); SHP-1(INDUCES) 17562706 1 0 0 inhibition of NK cell cytotoxicity +DAB2 DAB2 Adaptor/scaffold; Tumor suppressor P98082 1601 5p13.1 human S24-p 451211 QAAPKAPsKKEKKKG molecular association, regulation; intracellular localization transcription, altered ITGB3(INDUCES) 10542228; 15280374 4 3 0 N terminius of DAB2 negatively regulated TPA-induced AP-1 activity. +Tp53 p53 Activator; DNA-binding; Motility/polarity/chemotaxis; Nuclear receptor co-regulator; Transcription factor; Tumor suppressor P02340 22059 11 B3|11 42.83 cM mouse S375-p 447534 TKKGQSTsRHKKTMV acetylation 15794754 15 2 0 S375A (S378 in human) mutant stimulates p53 acetylation at K370 (K373 in human); S375D mutant (S378 in human) abrogates constitutive acetylation of p53 at K379 (K382 in human) and does not have any effect on acetylation of K370 (K373 in human) +Rps19 RPS19 Ribosomal; Translation P17074 rat S59-p 7113803 WFYTRAAsTARHLYL Ribosomal_S19e molecular association, regulation RPS19BP1(INDUCES) 19200342 1 0 0 +PRKCB PKCB iso2 EC 2.7.11.13; KINASE; Kinase, protein; Motility/polarity/chemotaxis; Protein kinase, AGC; Protein kinase, Ser/Thr (non-receptor) P05771-2 5579 16p12.2-p12.1 human S660-p 1869073011 QSEFEGFsFVNSEFL Pkinase_C intracellular localization; enzymatic activity, induced 10828076; 24236208 14 34 140 +HES1 HES1 Cell development/differentiation; Motility/polarity/chemotaxis; Transcription factor Q14469 3280 3q29 human S37-p 11424700 TASEHRKsSKPIMEK HLH molecular association, regulation cytoskeletal reorganization; transcription, altered DNA(DISRUPTS) 9389649 1 0 0 in vivo neurite outgrowth +FLT3 FLT3 EC 2.7.10.1; KINASE; Kinase, protein; Membrane protein, integral; Oncoprotein; Protein kinase, TK; Protein kinase, tyrosine (receptor) P36888 2322 13q12.2 human Y726-p 448644 KEHNFSFyPTFQSHP PK_Tyr_Ser-Thr phosphorylation 16627759 2 2 5 While none of the single mutations affected STAT-5 phosphotyrosine levels, 3 double mutations did: Y591/726F, Y591/955F, Y589/591F (all three pairs have Y591F in common). +Gne GNE Carbohydrate Metabolism - amino sugar and nucleotide sugar; Cell adhesion; Cytoskeletal; EC 2.7.1.60; EC 3.2.1.183; Isomerase; Kinase, other; Motility/polarity/chemotaxis O35826 114711 5q22 rat M712-p 21335600 ALLGAASmVLDYTTR ROK intracellular localization 21873062 1 0 0 M71YT mutation in insoluble fraction vs cytosolic for WT GNE +INPPL1 SHIP-2 Carbohydrate Metabolism - inositol phosphate; EC 3.1.3.86; Motility/polarity/chemotaxis; Phosphatase, lipid O15357 3636 11q13.4 human S132-p 468749 PPDDRDAsDGEDEKP protein degradation; intracellular localization; protein conformation; enzymatic activity, induced cytoskeletal reorganization 21770892; 23040614 2 33 0 +RPS6KB1 p70S6K EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, AGC; Protein kinase, Ser/Thr (non-receptor); Translation P23443 6198 17q23.1 human S447-p 448357 GSPRTPVsPVKFSPG activity, induced; molecular association, regulation; enzymatic activity, induced cell cycle regulation; cell adhesion, altered Tau iso8(NOT_REPORTED) 12759354; 15028555; 15051500; 15304500; 16364302; 35077510; 7545671 102 54 247 +MAPK6 ERK3 EC 2.7.11.24; KINASE; Kinase, protein; Protein kinase, CMGC; Protein kinase, Ser/Thr (non-receptor) Q16659 5597 15q21.2 human S688-p 13830503 QFHSPVGsPLKSIQA protein stabilization 20236090 1 9 8 +Mapk13 P38D EC 2.7.11.24; KINASE; Kinase, protein; Protein kinase, CMGC; Protein kinase, Ser/Thr (non-receptor) Q9Z1B7 26415 17|17 A3.3 mouse Y182-p 454935 TDTEMTGyVVTRWYR Pkinase enzymatic activity, induced 10066767; 9374491 4 22 997 +HOXB7 HOXB7 DNA-binding; Motility/polarity/chemotaxis; Transcription factor P09629 3217 17q21.32 human S133-p 465570 IYPWMRSsGTDRKRG cell differentiation, altered 11290787 1 0 0 +H3-4 HIST3H3 DNA-binding Q16695 8290 1q42.13 human K79-m2 14990400 REIAQDFkTDLRFQS Histone molecular association, regulation L3MBTL iso4(INDUCES) 23583077 0 3 1 +PTK2 FAK EC 2.7.10.2; KINASE; Kinase, protein; Protein kinase, TK; Protein kinase, tyrosine (non-receptor) Q05397 5747 8q24.3 human T474-p 60179302 KFLQEALtMRQFDHP PK_Tyr_Ser-Thr enzymatic activity, inhibited; protein conformation 27790061 1 0 0 T474 phosphorylation recruits SHP-2 to decrease FAK activity, FERM-mediated autoinhibition +DUOX1 DUOX1 EC 1.6.3.1; Membrane protein, integral; Membrane protein, multi-pass; Oxidoreductase Q9NRD9 53905 15q21.1 human S955-p 6370301 KDLCRRAsYISQDMI enzymatic activity, induced 19144650 1 3 0 +NOS1 nNOS Amino Acid Metabolism - arginine and proline; EC 1.14.13.39; Oxidoreductase P29475 4842 12q24.22 human Y609-p 465469 DYCDNSRyNILEEVA NO_synthase molecular association, regulation; enzymatic activity, inhibited Src(INDUCES) 16690617 1 0 0 prevents homodimerization +Anxa7 ANXA7 Calcium-binding; Lipid-binding; Motility/polarity/chemotaxis Q6IRJ7 155423 15p16 rat T261-p 18908667 VLIEILCtRTNQEIR Annexin molecular association, regulation SNAP23(INDUCES); SNAP-25(INDUCES) 29196215 3 1 0 +COIL coilin Oxidoreductase P38432 8161 17q22 human S184-p 11329300 NEEAKRKsPKKKEKC Coilin_N intracellular localization 11102515 3 2 0 S184A mutant localized to nucleolus +HMGN2 HMGN2 DNA-binding P05204 3151 1p36.11 human K36-sm 33622400 SAKPAPPkPEPKPKK HMG14_17 protein stabilization; molecular association, regulation chromatin organization, altered; transcription, induced DNA(DISRUPTS) 24872413 1 1 0 +TOB1 TOB1 Adaptor/scaffold; Cell cycle regulation P50616 10140 17q21.33 human S154-p 455536 SSVSSSPsPPFGHSA activity, inhibited cell cycle regulation; cell growth, inhibited; cell growth, altered 12050114; 12151396; 22252318 3 0 0 promote mRNA deadenylaion and decay and the ability to suppress proliferation; the antiproliferative activity of TOB1 is inhibited by phosphorylation.; the antiproliferative function of TOB1 is inhibited by phosphorylation. +FOXL2 FOXL2 DNA-binding; Transcription factor P58012 668 3q22.3 human S326-p 21697905 PGQLSPAsPATAAPP intracellular localization 22022399 1 1 0 +CTNND1 CTNND1 Actin-binding; Adaptor/scaffold; Cell adhesion; G protein regulator, misc.; Motility/polarity/chemotaxis O60716 1500 11q12.1 human S252-p 450456 MEGYRAPsRQDVYGP carcinogenesis, induced; cell motility, induced; cell adhesion, inhibited 32589661 6 54 205 +SSRP1 SSRP1 Nucleolus; RNA-binding; Transcription initiation complex; Transcription, coactivator/corepressor Q08945 6749 11q12.1 human S510-p 455268 SSSNEGDsDRDEKKR activity, inhibited transcription, altered 15659405 1 0 0 +PPP1R3F PPP1R3F Membrane protein, integral; Protein phosphatase, regulatory subunit Q6ZSY5 89801 Xp11.23 human S14-p 22497901 VEPPLRHsAPPSPAA signaling pathway regulation 21668450 1 5 0 regulation of glycogen synthesis via R3F-PP1 signaling in astrocytoma cells +Camk2b CAMK2B EC 2.7.11.17; KINASE; Kinase, protein; Protein kinase, CAMK; Protein kinase, Ser/Thr (non-receptor) P28652 12323 11 A1|11 3.89 cM mouse T311-p 15719513 ILTTMLAtRNFSVGR enzymatic activity, inhibited 36194579 2 5 2 +SORBS2 ArgBP2 iso2 Adaptor/scaffold; Motility/polarity/chemotaxis O94875-2 8470 4q35.1 human Y59-p 31834901 RPFSPSAySLPASLN protein conformation 24475245 1 0 0 reduced self-interaction +SLC12A3 NCCT Membrane protein, integral; Membrane protein, multi-pass; Transporter; Transporter, SLC family P55017 6559 16q13 human K706-ub 27200726 WLNKRKIkAFYSDVI SLC12 protein degradation; ubiquitination; activity, inhibited; phosphorylation endocytosis, induced 29021560 1 1 0 NCC transport activity decreased. phosphorylation inhibited +Ptpa PPP2R4 EC 5.2.1.8; Motility/polarity/chemotaxis; Protein phosphatase, regulatory subunit P58389 110854 2 B|2 21.71 cM mouse K28-ub 964537436 QNFIIPKkEIHTVPD PTPA protein degradation; ubiquitination; methylation cytoskeletal reorganization 31160454 1 2 0 mediating the effects of UBE3A on spine morphology. +Hist1h2ail1 H3 DNA-binding Q6LED0 291159 17p11 rat K14-ac 458954 ARKSTGGkAPRKQLA Histone molecular association, regulation chromatin organization, altered; transcription, induced; transcription, altered DNA(INDUCES) 17495236; 17628002; 17880897; 19476549; 19909801 162 31 355 +ETV1 ETV1 DNA-binding; Oncoprotein; Transcription factor P50549 2115 7p21.2 human S216-p 3059600 PMYQRQMsEPNIPFP ETS_PEA3_N activity, induced; protein stabilization; molecular association, regulation carcinogenesis, induced; cell motility, induced; transcription, induced 14-3-3 theta(INDUCES); 14-3-3 epsilon(INDUCES) 12213813; 23774214 3 3 2 MMP-1 transcription +UGT2B7 UGT2B7 Carbohydrate Metabolism - ascorbate and aldarate; Carbohydrate Metabolism - pentose and glucuronate interconversions; Carbohydrate Metabolism - starch and sucrose; Cofactor and Vitamin Metabolism - porphyrin and chlorophyll; Cofactor and Vitamin Metabolism - retinol; EC 2.4.1.17; Lipid Metabolism - androgen and estrogen; Membrane protein, integral; Transferase; Xenobiotic Metabolism - drug metabolism - cytochrome P450; Xenobiotic Metabolism - drug metabolism - other enzymes; Xenobiotic Metabolism - metabolism by cytochrome P450 P16662 7364 4q13.2 human Y438-p 7378201 RVINDPSyKENVMKL UDPGT enzymatic activity, induced 19289110; 21056984 2 1 0 +GAPDH GAPDH Carbohydrate Metabolism - glycolysis and gluconeogenesis; EC 1.2.1.12; Oxidoreductase P04406 2597 12p13.31 human Y94-p 25293196 WGDAGAEyVVESTGV Gp_dh_N enzymatic activity, induced 26629320 1 3 1 +Irak1bp1 IRAK1BP1 Transcription regulation Q9ESJ7 65099 9|9 E2 mouse S234-p 12524610 TVQQKIKsATIHAAS SIMPL intracellular localization transcription, altered 17079333 1 0 1 nuclear localization +IRAK1 IRAK1 EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, Ser/Thr (non-receptor); Protein kinase, TKL P51617 3654 Xq28 human T100-p 447720 LRARDIItAWHPPAP Death transcription, inhibited 11976320 1 0 0 +Gli2 GLI2 C2H2-type zinc finger protein; Oncoprotein; Transcription factor Q0VGT2 14633 1 E2.3|1 52.17 cM mouse R227-me 1877628102 TPRLSRKrALSISPL molecular association, regulation signaling pathway regulation SUFU(DISRUPTS) 31000813 1 0 0 increases Shh signaling leading to prevention of cellular senescence +Rorc RORC iso2 DNA-binding; Nuclear receptor; Transcription factor P51450-2 19885 3|3 F2.1 mouse S376-p 139835702 GCSELISsIFDFSHF Hormone_recep cell differentiation, induced; transcription, induced 28667162 1 1 0 +CELF1 CELF1 Cell development/differentiation; RNA processing; RNA-binding Q92879 10658 11p11.2 human S179-p 29668003 QTMEGCSsPMVVKFA RNA splicing, altered 24151077 1 3 0 splicing regulation in diabetes +CEP250 CEP250 Cell cycle regulation Q9BV73 11190 20q11.22 human S2417-p 20831304 ETRRLDEsLTQSLTS intracellular localization cell cycle regulation 21723128; 25660448 3 2 1 +Star STAR Carrier; Lipid-binding; Mitochondrial P70114 101844174 hamster S55-p 450439 ISQVRRRsSLLGSQL enzymatic activity, induced 15336703 3 1 0 +Map2 MAP2 iso3 Cytoskeletal; Motility/polarity/chemotaxis P15146-3 25595 9q32 rat K324-ac 62495506 IGSTDNIkYQPKGGQ Tubulin-binding cytoskeletal reorganization 28002468 1 1 0 +ACACA ACC1 Carbohydrate Metabolism - propanoate; Carbohydrate Metabolism - pyruvate; EC 6.3.4.14; EC 6.4.1.2; Ligase; Lipid Metabolism - fatty acid biosynthesis Q13085 31 17q12 human S80-p 448292 LHIRSSMsGLHLVKQ enzymatic activity, inhibited; intracellular localization; protein conformation carcinogenesis, altered; autophagy, induced; apoptosis, induced; cell growth, inhibited; apoptosis, inhibited 21918180; 28778925; 29899443; 30309849; 34362796; 34418433; 35761398; 36243112 166 76 11 +Prkd1 PRKD1 Autophagy; EC 2.7.11.13; KINASE; Kinase, protein; Motility/polarity/chemotaxis; Protein kinase, CAMK; Protein kinase, Ser/Thr (non-receptor) Q62101 18760 12|12 B3 mouse S403-p 4169976 EDSNRTIsPSTSNNI enzymatic activity, inhibited 19135240 1 36 3 in vitro +RIMS1 RIMS1 Adaptor/scaffold; Vesicle Q86UR5 22999 6q13 human K488-sm 31089520 AVLMRKAkREKVETM molecular association, regulation neural plasticity; exocytosis, induced CACNA1A(INDUCES) 24290762 1 0 0 +CRMP1 CRMP-1 Cell development/differentiation; Cytoskeletal; Hydrolase Q14194 1400 4p16.2 human T102-p 11539301 AALVGGTtMIIDHVV Amidohydro_1 cell cycle regulation 19799413 1 1 0 +Gab2 GAB2 Adaptor/scaffold Q9Z1S8 14389 7|7 E1 mouse S612-p 454021 ALDFQPGsPSPHRKP molecular association, regulation PIK3R1(DISRUPTS) 28096188 2 6 14 +PTOV1 PTOV1 Q86YD1 53635 19q13.33 human S36-p 11138413 VRAVRSRsWPASPRG protein stabilization; molecular association, regulation; intracellular localization 14-3-3 zeta(INDUCES); HUWE1(DISRUPTS) 34654719 1 19 6 +PANK4 PANK4 Cofactor and Vitamin Metabolism - pantothenate and CoA biosynthesis; EC 2.7.1.33; Kinase, other Q9NVE7 55229 1p36.32 human T406-p 478688 AQRARSGtFDLLEMD enzymatic activity, inhibited cell growth, induced 35896750 1 15 58 inhibits ACLY activity +LMNA lamin A/C Cytoskeletal P02545 4000 1q22 human S628-p 483561 TVTRSYRsVGGSGGG molecular association, regulation; intracellular localization 24741066 1 37 8 regulate assembly of lamin A +STK11 LKB1 Autophagy; EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, CAMK; Protein kinase, Ser/Thr (non-receptor); Tumor suppressor Q15831 6794 19p13.3 human K97-ac 3173802 NGEANVKkEIQLLRR Pkinase enzymatic activity, inhibited Other(INDUCES) 23086944 1 1 0 +LDHB LDH-B Amino Acid Metabolism - cysteine and methionine; Carbohydrate Metabolism - glycolysis and gluconeogenesis; Carbohydrate Metabolism - propanoate; Carbohydrate Metabolism - pyruvate; EC 1.1.1.27; Oxidoreductase P07195 3945 12p12.1 human S162-p 31882222 PKHRVIGsGCNLDSA enzymatic activity, induced cell cycle regulation; carcinogenesis, induced; cell growth, induced 31804482 1 3 0 promotes glycolysis +PTPN1 PTP1B EC 3.1.3.48; Motility/polarity/chemotaxis; PHOSPHATASE; Phosphatase; Protein phosphatase, tyrosine (non-receptor) P18031 5770 20q13.13 human K335-sm 12004414 FPNHQWVkEETQEDK enzymatic activity, inhibited signaling pathway regulation 17159996 1 0 0 insulin signaling +MAPK6 ERK3 EC 2.7.11.24; KINASE; Kinase, protein; Protein kinase, CMGC; Protein kinase, Ser/Thr (non-receptor) Q16659 5597 15q21.2 human S684-p 13830500 IGIPQFHsPVGSPLK protein stabilization 20236090 1 10 10 +MISP MISP Unknown function Q8IVT2 126353 19p13.3 human S471-p 457012 TMSPRHLsESSGKPL AKAP2_C molecular association, regulation ACTA1(DISRUPTS) 34023777 1 19 0 +Dok7 DOK7 Activator; Adaptor/scaffold Q18PE0 231134 5|5 B2 mouse Y406-p 17535700 PTSLRHHyDTPRSLR molecular association, regulation; phosphorylation MUSK(INDUCES); NCK1(INDUCES); CRKL(INDUCES); NCK2(INDUCES); CRK(INDUCES) 21041412 2 1 3 plays an important role in AChR clustering; stimulates MuSK and AChR phosphorylation +Src Src iso1 EC 2.7.10.2; KINASE; Kinase, protein; Oncoprotein; Protein kinase, TK; Protein kinase, tyrosine (non-receptor) P05480-1 20779 2 H1|2 78.35 cM mouse Y424-p 448234 RLIEDNEyTARQGAK PK_Tyr_Ser-Thr activity, induced; molecular association, regulation; phosphorylation; enzymatic activity, induced cell differentiation, altered; cytoskeletal reorganization GRB2(INDUCES) 11713208; 14739300; 20228840; 2460746; 30622194; 33203880 447 103 3046 represses osteoblast differentiation; required for normal organization of actin cytoskeleton and for bone resorption. +CEACAM1 CEACAM1 Cell adhesion; Immunoglobulin superfamily; Membrane protein, integral; Motility/polarity/chemotaxis P13688 634 19q13.2 human S461-p 6311908 FGKTGRAsDQRDLTE activity, inhibited apoptosis, altered 19146852 2 1 0 blocks formation of lumen +UBE2I UBC9 EC 6.3.2.-; EC 6.3.2.19; Ligase; Nuclear receptor co-regulator; SUMO LIGASE; SUMO conjugating system; SUMO ligase; UBIQUITIN LIGASE; Ubiquitin conjugating system; Ubiquitin ligase P63279 7329 16p13.3 human K65-sm 60338000 FKLRMLFkDDYPSSP UQ_con signaling pathway regulation 27501389 1 1 0 TTR specifically modulates general protein SUMOylation +RPS6KA2 RSK3 EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, AGC; Protein kinase, Ser/Thr (non-receptor); Translation; Tumor suppressor Q15349 6196 6q27 human S218-p 1883400 DHDKRAYsFCGTIEY Pkinase molecular association, regulation; enzymatic activity, induced AKAP6(DISRUPTS) 16337591; 7642538 2 2 4 +Bid BID Apoptosis; Mitochondrial P70444 12122 6 F1|6 57.02 cM mouse S64-p 448405 QTDGSQAsRSFNQGR BID protein stabilization apoptosis, inhibited 11583622 3 0 0 The double mutant S61A/S64A was used in this study +HSD17B13 HSD17B13 EC 1.1.-.-; Oxidoreductase; Secreted; Secreted, signal peptide Q7Z5P4 345275 4q22.1 human S33-p 4765436 FIPQRRKsVAGEIVL molecular association, regulation; enzymatic activity, inhibited; protein conformation PNPLA2(DISRUPTS) 36323699 1 5 0 +Cited1 CITED1 Nuclear receptor co-regulator P97769 12705 X D|X 45.25 cM mouse S64-p 3245861 ANGVPTSsSGSTSPI CITED intracellular localization cell differentiation, induced 23529225 1 0 0 S63/64/65/67/69/73/79/80/84A mutation in CITED1 inhibits its translocation into the nucleus and osteoblasts differentiation +TP53BP1 53BP1 DNA repair, damage; Transcription, coactivator/corepressor Q12888 7158 15q15.3 human S1678-p 476255 ITSEEERsPAKRGRK molecular association, regulation; intracellular localization signaling pathway regulation KPNA1(DISRUPTS); KPNB1(DISRUPTS); KPNA2(DISRUPTS) 29603287; 30685087 4 35 3 +TWIST1 TWIST1 Cell development/differentiation; DNA-binding; Inhibitor; Transcription regulation Q15672 7291 7p21.1 human S42-p 14821304 GGRKRRSsRRSAGGG protein degradation carcinogenesis, induced; apoptosis, altered 20400976; 26759241 5 1 0 +RARA RARA DNA-binding; Nuclear receptor; Oncoprotein; Transcription factor P10276 5914 17q21.2 human S96-p 465508 FVCQDKSsGYHYGVS zf-C4 activity, inhibited transcription, inhibited 16417524 1 0 0 +PIK3R1 PIK3R1 KINASE; Kinase, lipid; Motility/polarity/chemotaxis P27986 5295 5q13.1 human K459-sm 56709102 YNTQFQEkSREYDRL PI3K_P85_iSH2 carcinogenesis, induced; cell motility, induced 26411363 1 0 0 mutant induces phosphorylation and increases cell motility +Kcnj8 KCNJ8 Channel, potassium; Membrane protein, integral; Membrane protein, multi-pass Q63664 25472 4q44 rat S391-p 1458602 NSMRRNNsMRRSNSI activity, inhibited 18048350 1 0 0 +NOS2 iNOS Amino Acid Metabolism - arginine and proline; EC 1.14.13.39; Oxidoreductase P35228 4843 17q11.2 human Y1055-p 4115776 LPGKPKVyVQDILRQ NAD_binding_1 protein stabilization 19875457 1 2 4 +Ncoa3 SRC-3 ACETYLTRANSFERASE; Acetyltransferase; EC 2.3.1.48; Motility/polarity/chemotaxis; Nuclear receptor co-regulator; Transcription, coactivator/corepressor O09000 17979 2|2 H3 mouse S498-p 454109 SPAAGAHsPMGPSGN NCOA_u2 carcinogenesis, inhibited; cell growth, inhibited; cell differentiation, induced; transcription, inhibited; signaling pathway regulation 20534466 7 0 0 inhibits insulin/IGF1 signaling +FUS hnRNP P2 DNA-binding; Nuclear receptor co-regulator; Oncoprotein; RNA splicing; RNA-binding; SUMO LIGASE P35637 2521 16p11.2 human K315-ac 1877549400 IGIIKTNkKTGQPMI RRM_1 molecular association, regulation RNA(DISRUPTS) 32691043 1 1 0 +ESR1 ER-alpha DNA-binding; Nuclear receptor; Transcription factor P03372 2099 6q25.1-q25.2 human S104-p 448099 FPPLNSVsPSPLMLL Oest_recep activity, induced; molecular association, regulation carcinogenesis, induced; cell motility, induced; cell growth, induced; transcription, induced; transcription, altered Src(INDUCES); SRC-2(INDUCES); SRC-3(INDUCES); CBP(INDUCES) DNA(INDUCES) 11108261; 12714702; 16076840; 18372406; 23861392; 25531331; 26522726; 33542078 25 1 0 +TUFM EFTU Mitochondrial; RNA-binding; Translation; Translation elongation P49410 281556 cow Y266-p 464399 LLPVESVySIPGRGT molecular association, regulation translation, inhibited RNA(DISRUPTS) 36379377 1 1 11 +Pcyt2 PCYT2 EC 2.7.7.14; Lipid Metabolism - glycerophospholipid; Transferase Q922E4 68671 11|11 E2 mouse S223-p 31834921 QKIIQFAsGKEPQPG enzymatic activity, induced cell growth, induced 24519946 1 1 0 +RUNX2 AML3 DNA-binding; Transcription factor Q13950 860 6p21.1 human S294-p 10892804 DPRQAQSsPPWSYDQ transcription, induced 19801668 10 2 0 +Psmb6 PSMB6 EC 3.4.25.1; Protease; Proteasome complex Q60692 19175 11 B3|11 42.99 cM mouse S157-p 7320569 GGMMVRQsFAIGGSG Proteasome molecular association, regulation cell growth, inhibited p27Kip1(DISRUPTS) 23725357 1 1 0 Phosphorylation of PSMB6 at S157 inhibits degradation of p27Kip1. +Sirt1 SIRT1 Apoptosis; DEACETYLASE; Deacetylase; EC 3.5.1.-; Nuclear receptor co-regulator Q923E4 93759 10|10 B4 mouse S164-p 6006904 DDRTSHAsSSDWTPR intracellular localization; enzymatic activity, inhibited 28533219 1 4 0 inhibits its nuclear localization, inhibits fatty acid oxidation and promotes fatty liver +YAP1 YAP1 Oncoprotein; Transcription, coactivator/corepressor P46937 10413 11q22.1 human Y391-p 15565111 PFLNSGTyHSRDEST protein degradation; molecular association, regulation; ubiquitination; intracellular localization carcinogenesis, induced; carcinogenesis, inhibited; cell growth, induced; apoptosis, inhibited; transcription, induced SIAH1(INDUCES) 34253611; 35041461; 35723276 6 4 3 +AFP AFP Secreted; Secreted, signal peptide P02771 174 4q13.3 human K242-ac 1879738502 FQAITVTkLSQKFTK ubiquitination carcinogenesis, induced; cell motility, induced; cell growth, induced; apoptosis, inhibited 31811908 1 1 0 inhibits ubiquitination, promotes the migration and invasion +FERMT2 kindlin-2 Cytoskeletal; Motility/polarity/chemotaxis Q96AC1 10979 14q22.1 human K187-ub 1875153100 SSPGLYSkTMTPTYD protein degradation cell adhesion, inhibited 28408404 1 0 0 +CFTR CFTR Channel, chloride; EC 3.6.3.49; Hydrolase; Membrane protein, integral; Membrane protein, multi-pass; Transporter; Transporter, ABC family P13569 1080 7q31.2 human Y512-p 21041602 NIIFGVSyDEYRYRS ABC_tran intracellular localization endocytosis, induced 21807898; 21930781 2 0 0 regulates cell surface expression +PEX5 PEX5 iso3 Membrane protein, integral; Receptor, protein translocating P50542-3 5830 12p13.31 human K464-ub 1873159800 DSLFLEVkELFLAAV protein stabilization 28724525 1 0 0 regulates peroxisomal cargo protein import +Slc6a9 GlyT1 Membrane protein, integral; Membrane protein, multi-pass; Transporter, SLC family P28571 14664 4 D2.1|4 53.62 cM mouse S690-p 30984060 GSSRFQDsRI_____ molecular association, regulation PSD-95(DISRUPTS) 31741150 2 1 0 +Dab1 DAB1 Adaptor/scaffold P97318 13131 4 C6|4 47.79 cM mouse Y200-p 447960 VEDPVYQyIVFEAGH neural plasticity; cell differentiation, induced; cytoskeletal reorganization 14517291; 22586277 5 0 0 alternatively spliced variants +DYRK1B DYRK1B EC 2.7.12.1; KINASE; Kinase, protein; Protein kinase, CMGC; Protein kinase, dual-specificity (non-receptor) Q9Y463 9149 19q13.2 human Y271-p 458096 CQLGQRIyQYIQSRF Pkinase enzymatic activity, induced 10910078; 16257974 2 14 175 +SNCA SNCA Adaptor/scaffold P37840 6622 4q22.1 human K60-ub 1876998401 ATVAEKTkEQVTNVG Synuclein protein degradation; ubiquitination 31167929 1 2 0 ubiquitination and degradation of internalized SNCA fibrils +BLVRA BVR Cofactor and Vitamin Metabolism - porphyrin and chlorophyll; EC 1.3.1.24; KINASE; Kinase, protein; Oxidoreductase; Protein kinase, Ser/Thr (non-receptor) P53004 644 7p13 human S33-p 25526803 DLRNPHPsSAFLNLI GFO_IDH_MocA enzymatic activity, induced 22584576 1 1 0 +GRK1 GRK1 EC 2.7.11.14; KINASE; Kinase, protein; Protein kinase, AGC; Protein kinase, Ser/Thr (non-receptor) P28327 281457 cow S5-p 2528801 ___MDFGsLETVVAN enzymatic activity, induced 18339619 2 1 0 in vitro +Slc5a5 SLC5A5 Membrane protein, integral; Membrane protein, multi-pass; Transporter; Transporter, SLC family Q63008 114613 16p14 rat T577-p 990308 APKEDTAtLEESLVK activity, induced; protein stabilization 17913707 1 1 0 +SMAD7 SMAD7 DNA-binding; Transcription factor O15105 4092 18q21.1 human S206-p 1869370301 SRLCELEsPPPPYSR molecular association, regulation WWP2(INDUCES) 31546607 1 0 0 +PELP1 PELP1 Nuclear receptor co-regulator; Transcription, coactivator/corepressor Q8IZL8 27043 17p13.2 human Y920-p 473548 EEEDEEEyFEEEEEE molecular association, regulation apoptosis, inhibited; cell growth, altered PIK3R1(INDUCES) 17194752 1 0 0 +KPNA2 KPNA2 Karyopherin; Nuclear import; Nucleoporin P52292 3838 17q24.2 human S105-p 454033 QAARKLLsREKQPPI activity, induced; molecular association, regulation; intracellular localization HuR(INDUCES) 15342649; 17919121 3 0 0 regulates HuR nuclear import through S105 phosphorylation and K22 acetylation ; promotes the nuclear localization of HuR +PDE4B PDE4B EC 3.1.4.53; Nucleotide Metabolism - purine; Phosphodiesterase Q07343 5142 1p31.3 human S133-p 449097 GHSQRREsFLYRSDS enzymatic activity, induced 12023945 4 22 1 +HSF1 HSF1 DNA-binding; Transcription factor Q00613 3297 8q24.3 human S230-p 448072 PKYSRQFsLEHVHGS activity, induced; molecular association, regulation; intracellular localization; activity, inhibited carcinogenesis, induced; cell growth, induced; apoptosis, induced; transcription, induced; transcription, inhibited CDK9(INDUCES) DNA(INDUCES) 23587601; 25380824; 25963659; 26361762; 33177089; 35080342 16 2 4 +NDC80 HEC1 Cell cycle regulation O14777 10403 18p11.32 human S75-p 1877641900 NSQLGIFsSSEKIKD Ndc80_HEC cytoskeletal reorganization 35878017 1 1 0 +EGFR EGFR EC 2.7.10.1; KINASE; Kinase, protein; Membrane protein, integral; Oncoprotein; Protein kinase, TK; Protein kinase, tyrosine (receptor) P00533 1956 7p11.2 human Y891-p 36100600 ESILHRIyTHQSDVW PK_Tyr_Ser-Thr molecular association, regulation SH3BGRL3(INDUCES) 16729043 1 0 0 +GPRC5A RAIG1 GPCR, family 3; Membrane protein, integral; Membrane protein, multi-pass; Receptor, GPCR Q8NFJ5 9052 12p13.1 human Y350-p 450339 WPSPYKDyEVKKEGS cell growth, induced 25311788 1 24 803 Tyrosine phosphorylation inhibits the suppressive effect of RAIG1 on cell invasion and anchorage-independent growth. +MAPK8IP1 JIP1 Adaptor/scaffold Q9UQF2 9479 11p11.2 human S421-p 458259 DNCASVSsPYESAIG protein conformation 24914561 3 1 0 promotes anterograde autophagosome transport +ORAI1 ORAI1 Channel, calcium; Membrane protein, integral; Membrane protein, multi-pass Q96D31 84876 12q24.31 human S27-p 469411 GGSTTSGsRRSRRRS activity, induced; molecular association, regulation; intracellular localization; activity, inhibited cell growth, inhibited; cell motility, inhibited IP3R2(INDUCES) 20534587; 23144458; 31652779; 35805121 5 0 0 +ENG ENG Membrane protein, integral; Motility/polarity/chemotaxis; Receptor, misc. P17813 2022 9q34.11 human Y612-p 34729906 LLTAALWyIYSHTRS receptor internalization, induced; protein degradation; intracellular localization cell motility, induced; cell growth, induced 25070888 1 0 0 1)ALK1, TBRII, ENG degradation 2) induces endothelial capillary sprouting and stability, EC functions during angiogenesis +MDM2 MDM2 EC 6.3.2.-; EC 6.3.2.19; Inhibitor; Ligase; NEDDYLATION LIGASE; Neddylation Ligase; Nucleolus; Oncoprotein; UBIQUITIN LIGASE; Ubiquitin conjugating system; Ubiquitin ligase Q00987 4193 12q15 human S157-p 455457 SHLVSRPsTSSRRRA enzymatic activity, induced cell cycle regulation; apoptosis, altered 15688025 1 0 0 increases E3 ligase activity toward p53 and promotes p53 degradation +PTEN PTEN Carbohydrate Metabolism - inositol phosphate; EC 3.1.3.16; EC 3.1.3.48; EC 3.1.3.67; Motility/polarity/chemotaxis; Nuclear receptor co-regulator; PHOSPHATASE; Phosphatase, lipid; Tumor suppressor P60484 5728 10q23.31 human K125-ac 470077 HVAAIHCkAGKGRTG molecular association, regulation; enzymatic activity, inhibited; phosphorylation cell cycle regulation; carcinogenesis, inhibited; signaling pathway regulation MTA1(INDUCES) 16829519; 25447541 2 0 0 decreases p-Akt at S473; regulation of PI3K/AKT pathway, reduced phosphorylation of Akt +TP63 p63 DNA-binding; Transcription factor Q9H3D4 8626 3q28 human S560-p 4668108 LARLGCSsCLDYFTT SAM_2 protein degradation 18769144 1 1 0 +CSF2RB CSF2RB Membrane protein, integral; Receptor, cytokine P32927 1439 22q12.3 human Y822-p 450124 VLQQVGDyCFLPGLG activity, induced apoptosis, altered; transcription, altered; cell growth, altered 10329850; 10672044 2 0 0 +MYC Myc DNA-binding; Nucleolus; Oncoprotein; Transcription factor P01106 4609 8q24.21 human R314-me 1873076612 HSPLVLKrCHVSTHQ Myc_N molecular association, regulation transcription, induced p300(INDUCES); MAX(INDUCES) 28652407 1 1 0 proximity ligation assay (PLA) +H2AC11 H2A.1 DNA-binding P0C0S8 8329 6p22.1 human Y57-p 1874775700 YLAAVLEyLTAEILE Histone carcinogenesis, inhibited; cell growth, inhibited; apoptosis, induced; cell motility, inhibited 34532094 1 0 0 +TERF1 TRF1 DNA-binding P54274 7013 8q21.11 human T122-p 2481000 LTACQLRtIYICQFL TRF protein stabilization; molecular association, regulation; intracellular localization TRF1(INDUCES); CK2B(INDUCES) DNA(INDUCES) 18347021; 24415760 2 0 0 regulates telomere length ; PinX1 stabilizes T122A mutant and allows binding to telomeres. +EPAS1 HIF2A DNA-binding; Transcription factor Q99814 2034 2p21 human K741-ac 7761200 HLMWKRMkNLRGGSC transcription, inhibited 19498162 2 1 0 +Gria1 GluR1 Channel, calcium; Channel, ligand-gated; Membrane protein, integral; Membrane protein, multi-pass P23818 14799 11 B1.3|11 34.51 cM mouse S863-p 448566 TSTLPRNsGAGASGG activity, induced; protein stabilization; receptor desensitization, altered; intracellular localization; receptor internalization, altered; receptor recycling, altered; phosphorylation neural plasticity 12628184; 17689977; 17880895; 17923095; 19892736; 19906877; 21483826; 21738458; 24706758; 33979625; 34642320; 34664085 102 0 0 +Ikzf1 Ikaros C2H2-type zinc finger protein; DNA-binding; Transcription factor Q03267 22778 11 A1|11 7.02 cM mouse K239-sm 3609103 PGVCPVIkEETNHNE molecular association, regulation transcription, induced SIN3A(DISRUPTS); SIN3B(DISRUPTS); CHD-4(DISRUPTS); CTBP1(DISRUPTS) 15767674 2 0 0 +MEF2C MEF2C DNA-binding; Transcription factor Q06413 4208 5q14.3 human S222-p 474086 GYGNPRNsPGLLVSP cell cycle regulation; apoptosis, inhibited; transcription, induced 29431698 1 33 1 AML chemotherapy resistance; required for leukemia maintenance +Nos1 nNOS Amino Acid Metabolism - arginine and proline; EC 1.14.13.39; Oxidoreductase P29476 24598 12q16 rat T1296-p 457129 DHIYREEtLQAKNKG NAD_binding_1 enzymatic activity, inhibited 16214135 1 0 0 +KLF8 KLF8 C2H2-type zinc finger protein; DNA-binding; Transcription factor O95600 11279 Xp11.21 human K67-ac 25344507 PALFNDIkIEPPEEL transcription, inhibited 21416054 1 1 0 +CDC14A CDC14A EC 3.1.3.16; EC 3.1.3.48; Motility/polarity/chemotaxis; PHOSPHATASE; Protein phosphatase, dual-specificity Q9UNH5 8556 1p21.2 human S453-p 1216243801 KTSKMALsPSATAKR molecular association, regulation 30089874 1 1 0 interaction with putative unknown substrates or regulators +CDK9 CDK9 Cell cycle regulation; EC 2.7.11.22; EC 2.7.11.23; KINASE; Kinase, protein; Nuclear receptor co-regulator; Protein kinase, CMGC; Protein kinase, Ser/Thr (non-receptor) P50750 1025 9q34.11 human S175-p 456536 FGLARAFsLAKNSQP Pkinase molecular association, regulation; intracellular localization; enzymatic activity, inhibited; enzymatic activity, induced transcription, induced; transcription, altered TAT-SF1(DISRUPTS); LARP7(DISRUPTS); HEXIM1(DISRUPTS); CCNT1(INDUCES); TAT(INDUCES); BRD4(INDUCES); BRD4(NOT_REPORTED) 16109377; 21533037; 23658523; 28250118; 29743242 7 4 1 S175-p is found in nuclear speckles; CDK9 S175A mutant activates HIV-1 transcription; essential for mediating proviral reactivation by Tat (Molecular dynamics simulations); S175 CDK9 was recruited to the RNA-positive HIV-1 DNA; Mutation to A or D abrogates binding. Mutation to D activates the kinase (S->A abolishes kinase activity). The S->D mutation is defective as a transcription factor (due to no Brd4 binding which leads to less promoter binding and Mediator interactions). +Vdac1 VDAC1 Channel, misc.; Membrane protein, integral; Mitochondrial Q60932 22333 11 B1.3|11 31.86 cM mouse T55-p 1875831100 SENGLEFtSSGSANT Porin_3 molecular association, regulation HK2(DISRUPTS) 34949833 1 0 0 +Trpv4 TRPV4 Channel, cation; Membrane protein, integral; Membrane protein, multi-pass Q9EPK8 63873 5|5 F mouse S824-p 4777181 LRRDRWSsVVPRVVE activity, induced; protein stabilization; molecular association, regulation; intracellular localization apoptosis, inhibited Other(INDUCES) 22101010 8 3 0 S824D mutant shows enhanced interaction with F-actin +SHB SHB Adaptor/scaffold Q15464 6461 9p13.1 human Y336-p 451593 DDRPADEyDQPWEWN molecular association, regulation cell motility, induced; signaling pathway regulation ARHGAP2(INDUCES); ARHGAP3(INDUCES) 32060095 1 22 344 regulates EphB2 signaling +EPHA4 EphA4 EC 2.7.10.1; KINASE; Kinase, protein; Membrane protein, integral; Protein kinase, TK; Protein kinase, tyrosine (receptor) P54764 2043 2q36.1 human Y602-p 450857 TYVDPFTyEDPNQAV EphA2_TM molecular association, regulation; enzymatic activity, induced carcinogenesis, inhibited; cell motility, inhibited Fyn(INDUCES) 21439481; 36181793; 8622893 7 16 155 +Ptpn6 SHP-1 EC 3.1.3.48; Motility/polarity/chemotaxis; PHOSPHATASE; Protein phosphatase, tyrosine (non-receptor) P29351 15170 6 F2|6 59.17 cM mouse T394-p 23144271 TAEYKLRtLQISPLD Y_phosphatase phosphorylation; enzymatic activity, induced signaling pathway regulation 31011187 2 1 1 induces SYK dephosphorylation, induces phosphorylation of Lyn, regulates BCR signaling +H2bc15 H2B DNA-binding P10853 319187 13|13 A3.1 mouse S38-p 4702417 RSRKESYsVYVYKVL Histone chromatin organization, altered 19434510 0 9 4 regulation of senescence-related epigenetics modification +Amelx AMELX Secreted; Secreted, signal peptide P63277 11704 X F5|X 78.95 cM mouse S32-p 34729901 SPGYINLsYEKSHSQ Amelogenin cytoskeletal reorganization 31919099 4 1 0 regulate ACP phase transformation and enamel growth and amelogenesis, ameloblast integrity +ABL1 Abl EC 2.7.10.2; KINASE; Kinase, protein; Oncoprotein; Protein kinase, TK; Protein kinase, tyrosine (non-receptor) P00519 25 9q34.12 human Y257-p 450300 GGQYGEVyEGVWKKY PK_Tyr_Ser-Thr intracellular localization; protein conformation 21347248 4 13 323 +POLR2A POLR2A EC 2.7.7.48; EC 2.7.7.6; Nucleotide Metabolism - purine; Nucleotide Metabolism - pyrimidine; Transcription initiation complex; Transferase P24928 5430 17p13.1 human T1525-p 1239966001 TPWNQGAtPAYGAWS molecular association, regulation transcription, induced SPT6(INDUCES) 30135578 1 1 0 +Rplp2 RPLP2 Ribosomal; Translation P02401 140662 1q41 rat S105-p 454320 KKEESEEsDDDMGFG Ribosomal_60s activity, induced translation, altered 12379128 3 117 360 +Smo SMO Cell development/differentiation; GPCR, Fz/Smo family; Membrane protein, integral; Membrane protein, multi-pass; Oncoprotein; Receptor, GPCR P56726 319757 6 A3.3|6 12.36 cM mouse S599-p 1872776118 SFSMHTVsHDGPVAG molecular association, regulation transcription, induced PKACA(INDUCES) 33886552 1 1 0 +Syngap1 SynGAP iso3 GAP; GAP, Ras Q9QUH6-3 192117 20p12 rat S836-p 4792755 AGRLSQGsGSSITAA DUF3498 molecular association, regulation; intracellular localization HRas(INDUCES) 21382555 1 5 2 +Dlg1 DLG1 Adaptor/scaffold; Motility/polarity/chemotaxis Q62696 25252 11q22 rat S39-p 451614 SSIERVIsIFQSNLF L27_1 molecular association, regulation; intracellular localization NMDAR2A(INDUCES) 15044483; 17156128 3 0 0 facilitates the release of SAP97 from the endoplasmic reticulum; induces SAP97/NMDAR2A trafficking to the postsynaptic compartment +Dab2 DAB2 Adaptor/scaffold; Tumor suppressor O88797 79128 2q16 rat S24-p 451211 QAAPKAPsKKEKKKG molecular association, regulation transcription, altered MIB1(INDUCES) 11812785 4 3 0 +Klf10 KLF10 C2H2-type zinc finger protein; DNA-binding; Transcription factor O89091 21847 15|15 B3.1 mouse Y179-p 18958500 KAASILNyQDNSFRR ubiquitination; intracellular localization carcinogenesis, inhibited; cell differentiation, induced; transcription, inhibited 21471442 1 0 0 +Pth1r PTHR GPCR, family 2; Membrane protein, integral; Membrane protein, multi-pass; Receptor, GPCR P25961 56813 8q32 rat S492-p 2853102 RKARSGSsSYSYGPM receptor internalization, altered; activity, inhibited 11773434; 18577695 4 2 1 +CBL CBL Adaptor/scaffold; EC 6.3.2.-; EC 6.3.2.19; Ligase; Motility/polarity/chemotaxis; Oncoprotein; UBIQUITIN LIGASE; Ubiquitin conjugating system; Ubiquitin ligase P22681 867 11q23.3 human Y368-p 455273 IKVTQEQyELYCEMG molecular association, regulation; protein conformation; enzymatic activity, induced EGFR(INDUCES) 15117950 1 2 3 +MCM4 MCM4 DNA replication; EC 3.6.4.12 P33991 4173 8q11.21 human T110-p 450002 PRSGVRGtPVRQRPD activity, inhibited 12714602 2 20 7 +ERBB2 HER2 EC 2.7.10.1; KINASE; Kinase, protein; Membrane protein, integral; Oncoprotein; Protein kinase, TK; Protein kinase, tyrosine (receptor) P04626 2064 17q12 human Y735-p 458002 SGAFGTVyKGIWIPD PK_Tyr_Ser-Thr molecular association, regulation SHC1(INDUCES) 16729043 1 14 150 +AR AR DNA-binding; Nuclear receptor; Transcription factor P10275 367 Xq12 human S310-p 448413 TEDTAEYsPFKGGYT Androgen_recep protein stabilization; molecular association, regulation; activity, inhibited cell growth, inhibited; transcription, induced; transcription, inhibited; transcription, altered CREB3 iso3(INDUCES) DNA(DISRUPTS) 15684382; 17698582; 24441043; 25691442; 25851605; 31429764 11 5 0 +VIM Vimentin Cytoskeletal; Motility/polarity/chemotaxis P08670 7431 10p13 human S55-gl 5262500 TSRSLYAsSPGGVYA Filament_head intracellular localization 17507370 1 1 0 in the hyperphosphorylated head domain of vimentin +Gab1 GAB1 Adaptor/scaffold; Motility/polarity/chemotaxis Q9QYY0 14388 8|8 C2 mouse Y407-p 447946 DASSQDCyDIPRTFP molecular association, regulation cell differentiation, altered; cell growth, altered PLCG1(INDUCES) 10734310 4 37 1082 +CTCF CTCF C2H2-type zinc finger protein; Transcription factor; Tumor suppressor Q08705 396274 chicken S609-p 448303 MRSKKEDsSDSEENA transcription, altered; cell growth, altered 11238955 1 8 0 +LGR5 LGR5 GPCR, family 1; Membrane protein, integral; Membrane protein, multi-pass; Receptor, GPCR O75473 8549 12q21.1 human S864-p 27806300 VEKQSCDsTQALVTF receptor internalization, induced 23439653 1 0 0 constitutive internalization. Sites S844, S848, S851 and S854 may secondarily contribute to LGR5 internalization. +Pparg PPAR-gamma DNA-binding; Nuclear receptor; Transcription factor O88275 25664 4q42 rat S112-p 448062 AIKVEPAsPPYYSEK cell differentiation, induced; transcription, induced 35121022; 36840344 33 7 0 +ANAPC1 APC1 Cell cycle regulation; Ubiquitin conjugating system Q9H1A4 64682 2q13 human S377-p 455827 NISSHNQsPKRHSIS activity, induced 27120157 2 40 1 +NPFFR2 NPFFR2 GPCR, family 1; Membrane protein, integral; Membrane protein, multi-pass; Receptor, GPCR Q9Y5X5 10886 4q13.3 human S520-p 36533409 LKETTNSsEI_____ receptor desensitization, induced 25326382 1 1 0 +CDCP1 CDCP1 Cell surface; Membrane protein, integral Q9H5V8 64866 3p21.31 human Y707-p 451576 KGPAVGIyNDNINTE carcinogenesis, induced; cell growth, induced 25728678 2 12 313 Tyr734 is a key precursor phosphorylation event allowing Tyr707 and Tyr806 phosphorylation +Csf3r GCSFR Membrane protein, integral; Receptor, cytokine P40223 12986 4 D2.2|4 59.77 cM mouse K786-ub 4664705 GGPTPSPkSYENIWF carcinogenesis, inhibited; cell growth, induced; transcription, induced; signaling pathway regulation 18923646; 18931787 2 0 0 +Egfr EGFR EC 2.7.10.1; KINASE; Kinase, protein; Membrane protein, integral; Oncoprotein; Protein kinase, TK; Protein kinase, tyrosine (receptor) Q01279 13649 11 A2|11 9.41 cM mouse Y270-p 457625 TCPPLMLyNPTTYQM Furin-like molecular association, regulation EGFR(INDUCES) 15016810 1 0 0 +NR3C1 GR DNA-binding; Mitochondrial; Nuclear receptor; Transcription factor P04150 2908 5q31.3 human K492-ac 6741600 GMNLEARkTKKKIKG molecular association, regulation transcription, inhibited DNA(DISRUPTS) 19141540 1 0 0 +Camk2a CAMK2A EC 2.7.11.17; KINASE; Kinase, protein; Protein kinase, CAMK; Protein kinase, Ser/Thr (non-receptor) P11798 12322 18 E1|18 34.41 cM mouse T305-p 448802 KLKGAILtTMLATRN molecular association, regulation; enzymatic activity, inhibited; intracellular localization; phosphorylation neural plasticity NMDAR2B(DISRUPTS); Calmodulin(DISRUPTS) 12408851; 28636948; 33064361; 33853773 24 5 1 regulates phosphorylation at T286 and of GluA1 at S831 +PPARD PPAR-delta DNA-binding; Nuclear receptor A9XAM2 pig K16-ub 62484400 PEVREEEkKKEVAEA transcription, induced 24058710 1 0 0 +CDC34 CDC34 EC 6.3.2.19; Ligase; UBIQUITIN LIGASE; Ubiquitin conjugating system; Ubiquitin ligase P49427 997 19p13.3 human S222-p 448688 EVEEEADsCFGDDED intracellular localization 11546811 2 0 0 +Kcnj3 GIRK1 Channel, potassium; Membrane protein, integral; Membrane protein, multi-pass P63250 16519 2|2 C1.1 mouse Y12-p 457610 RRKFGDDyQVVTTSS activity, inhibited 19773548; 26377476 5 0 0 enhances channel deactivation; decreases channel conductance +TTK TTK Cancer Testis Antigen (CTA); EC 2.7.12.1; KINASE; Kinase, protein; Protein kinase, Other; Protein kinase, dual-specificity (non-receptor) P33981 7272 6q14.1 human S108-p 41389701 DKYGQNEsFARIQVR intracellular localization; enzymatic activity, induced 26119734 1 1 0 regulates spindle assembly checkpoint and recruitment of SAC proteins +PRKCQ PKCT EC 2.7.11.13; KINASE; Kinase, protein; Protein kinase, AGC; Protein kinase, Ser/Thr (non-receptor) Q04759 5588 10p15.1 human S676-p 447905 LNEKPRLsFADRALI Pkinase_C enzymatic activity, induced transcription, altered 11772397; 16252004 7 17 10 inhibits transcription; assayed in vitro +Fbxl21 FBXL21 UBIQUITIN LIGASE; Ubiquitin ligase Q8BFZ4 213311 13|13 B1 mouse S37-p 1880462804 LRQTHALsVLLDWGT enzymatic activity, induced cell differentiation, induced 36574402 1 0 0 induces MYOZ1 degradation +SLC22A6 SLC22A6 Membrane protein, integral; Membrane protein, multi-pass; Transporter; Transporter, SLC family Q4U2R8 9356 11q12.3 human K303-ub 53529107 GKREEGAkLSMEVLR Sugar_tr receptor internalization, induced 23640180 1 0 0 +RPS6KB1 p70S6K EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, AGC; Protein kinase, Ser/Thr (non-receptor); Translation P23443 6198 17q23.1 human S441-p 450015 SPRRFIGsPRTPVSP enzymatic activity, induced 7545671 11 31 89 +RPS6 S6 Translation P62753 6194 9p22.1 human S240-p 448094 RLSSLRAsTSKSESS carcinogenesis, induced; carcinogenesis, inhibited; apoptosis, induced; cell growth, induced; apoptosis, inhibited; autophagy, inhibited; signaling pathway regulation 33676898; 34762647; 36149602; 36715448; 37624695 111 69 847 +AGTR1 AT1 GPCR, family 1; Membrane protein, integral; Membrane protein, multi-pass; Receptor, GPCR P30556 185 3q24 human T332-p 467239 KSHSNLStKMSTLSY activity, induced; molecular association, regulation; intracellular localization; receptor internalization, altered ARRB1(INDUCES); ARRB2(INDUCES) 11579203; 15177932 3 0 0 +TP53 p53 Activator; DNA-binding; Motility/polarity/chemotaxis; Nuclear receptor co-regulator; Transcription factor; Tumor suppressor P04637 7157 17p13.1 human T387-p 455224 HKKLMFKtEGPDSD_ activity, induced; molecular association, regulation transcription, altered S100B(DISRUPTS); p53(INDUCES); 14-3-3 epsilon(INDUCES); 14-3-3 gamma(INDUCES); S100A2(DISRUPTS) DNA(INDUCES) 15659650; 18812399; 19819244; 19933256 3 1 0 +CCDC6 CCDC6 Apoptosis; Cytoskeletal; Oncoprotein Q16204 8030 10q21.2 human S244-p 450707 QPVSAPPsPRDISME DUF2046 activity, induced apoptosis, induced 14712216 3 100 40 +MAPK7 ERK5 EC 2.7.11.24; KINASE; Kinase, protein; Protein kinase, CMGC; Protein kinase, Ser/Thr (non-receptor) Q13164 5598 17p11.2 human S803-p 20572701 QREIQMDsPMLLADL intracellular localization; enzymatic activity, inhibited transcription, altered 20667468 1 4 0 +RBBP8 CtIP EC 3.1.-.-; Transcription, coactivator/corepressor Q99708 5932 18q11.2 human S664-p 448391 IDPGADLsQYKMDVT molecular association, regulation; enzymatic activity, induced BRCA1(DISRUPTS) 10910365; 24837676 2 1 0 +WWP2 WWP2 EC 6.3.2.-; EC 6.3.2.19; Ligase; UBIQUITIN LIGASE; Ubiquitin conjugating system; Ubiquitin ligase O00308 11060 16q22.1 human Y392-p 10369541 HFSQRFLyQSSSAST enzymatic activity, induced 35331737 1 0 1 +RAPGEF3 Epac1 iso3 GEF; GEF, misc. O95398-3 10411 12q13.11 human S108-p 54400804 GLGVHSRsQVVGICQ DEP intracellular localization 26929333 1 0 0 GRK2-mediated inhibition of Rap1 activation, inhibits plasma membrane association +RORC RORC DNA-binding; Nuclear receptor; Transcription factor P51449 6097 1q21.3 human S205-p 4708350 ASCHLEYsPERGKAE transcription, altered 35294872 1 3 0 +HIF1A HIF1A Autophagy; DNA-binding; Transcription factor Q16665 3091 14q23.2 human T555-p 34362821 NPFSTQDtDLDLEML HIF-1 protein degradation cell growth, inhibited; cell motility, inhibited; signaling pathway regulation 30254159 1 0 1 PI3K pathway and AKT are strongly activated by IRIS +Rps6ka3 RSK2 EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, AGC; Protein kinase, Ser/Thr (non-receptor) P18654 110651 X F4|X 73.27 cM mouse T577-p 450152 AENGLLMtPCYTANF Pkinase enzymatic activity, induced 10480933 10 14 180 +DNAJB8 DNAJB8 Chaperone Q8NHS0 165721 3q21.3 human K223-ac 7813482 KSVTVNGkEQLKWMD activity, induced 20159555 1 2 1 +FOXP3 FOXP3 C2H2-type zinc finger protein; Cell cycle regulation; DNA-binding; Transcription factor Q9BZS1 50943 Xp11.23 human K179-ac 31914101 PNPSAPRkDSTLSAV protein stabilization 23644046 1 0 0 +Ikzf1 Ikaros C2H2-type zinc finger protein; DNA-binding; Transcription factor Q03267 22778 11 A1|11 7.02 cM mouse S213-p 28735108 GRSYKQRsSLEEHKE zf-C2H2 molecular association, regulation; intracellular localization transcription, induced DNA(INDUCES) 23977012 1 1 0 nuclear localization, ITGA4, MDM1, EIF4E3, KIF23, TNFAIP8L2 DNA binding/transcription inhibited by BTK siRNA +PLA2G4A PLA2G4A EC 3.1.1.4; EC 3.1.1.5; Lipid Metabolism - alpha-linolenic acid; Lipid Metabolism - arachidonic acid; Lipid Metabolism - ether lipid; Lipid Metabolism - glycerophospholipid; Lipid Metabolism - linoleic acid; Phospholipase P47712 5321 1q31.1 human T376-p 1869344400 GSKFFMGtVVKKYEE PLA2_B enzymatic activity, induced carcinogenesis, induced; signaling pathway regulation 32559461 1 0 0 regulates mTORC2-PKC?-cPLA2 signaling +WBP2 WBP2 Cell development/differentiation; Nuclear receptor co-regulator Q969T9 23558 17q25.1 human Y231-p 464521 AEAAASAyYNPGNPH molecular association, regulation; intracellular localization carcinogenesis, induced; cell growth, induced; transcription, induced ER-alpha(INDUCES) 21642474 1 1 62 epithelial-mesenchymal transition induced +Ulk1 ULK1 Autophagy; EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, Other; Protein kinase, Ser/Thr (non-receptor) O70405 22241 5|5 F mouse S622-p 2047929 PLPPILGsPTKAGPS cell cycle regulation; autophagy, induced; cell growth, induced 32516310 1 30 2 +Rasgrf1 RASGRF1 GEF; GEF, Ras P28818 192213 8q31 rat S731-p 469604 PLAIGTSsPVRRRKL RasGEF_N protein degradation 16921254 1 2 1 causes nuclear disorganization in CHO cells +CNGA1 CNGA1 Channel, cation; Membrane protein, integral; Membrane protein, multi-pass Q00194 281700 cow Y503-p 27166602 QVYSPGDyICKKGDI cNMP_binding activity, inhibited 23032687 1 0 0 inhibits channel activity +PAK4 PAK4 EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, STE; Protein kinase, Ser/Thr (non-receptor) O96013 10298 19q13.2 human S99-p 2192540 MSVTRSNsLRRDSPP molecular association, regulation; intracellular localization; phosphorylation carcinogenesis, induced; cell motility, induced; cytoskeletal reorganization; cell motility, inhibited 14-3-3 zeta(INDUCES); 14-3-3 gamma(INDUCES) 23841590; 35593474; 35969127 3 12 0 +KIF22 KIF22 Microtubule-binding; Motor Q14807 3835 16p11.2 human T463-p 456110 QGAPLLStPKRERMV intracellular localization; activity, inhibited cell cycle regulation; cytoskeletal reorganization TUBA4A(DISRUPTS) 12727876; 27550518; 35730929 3 13 21 +Foxo1 FOXO1A DNA-binding; Nuclear receptor co-regulator; Oncoprotein; Transcription factor Q9R1E0 56458 3 C|3 23.19 cM mouse S209-p 4258803 SSAGWKNsIRHNLSL Forkhead protein stabilization 24453252 3 1 0 +Cldn16 Claudin-16 Cell adhesion; Membrane protein, integral; Membrane protein, multi-pass Q91Y55 155268 11q22 rat S217-p 2872000 AGVSMAKsYKAPRTE activity, induced; protein stabilization; intracellular localization 16608877 1 0 0 +TDP1 TDP1 DNA repair, damage; EC 3.1.4.-; Phosphodiesterase Q9NUW8 55775 14q32.11 human R586-m2 1883845001 ELYGSKDrPWIWNIP protein degradation; ubiquitination DNA repair, induced XRCC1(INDUCES); UCHL3(DISRUPTS) 35705029 1 0 0 +MEF2A MEF2A DNA-binding; Motility/polarity/chemotaxis; Transcription factor Q02078 4205 15q26.3 human T319-p 448098 TPVVSVTtPSLPPQG activity, induced transcription, altered 10849446; 9858528 2 0 0 +EIF2S2 eIF2-beta Translation; Translation initiation P20042 8894 20q11.22 human S2-p 451805 ______MsGDEMIFD translation, altered; cell growth, altered 16225457 4 52 0 +Cdh1 CDH1 Cell adhesion; Membrane protein, integral; Motility/polarity/chemotaxis; UBIQUITIN LIGASE; Ubiquitin ligase P09803 12550 8 D3|8 53.18 cM mouse S855-p 465567 SSLNSSEsDQDQDYD CADH_Y-type_LIR molecular association, regulation cell adhesion, altered CTNNB1(INDUCES) 10671552 3 0 0 +Ep300 p300 ACETYLTRANSFERASE; Acetyltransferase; EC 2.3.1.48; Motility/polarity/chemotaxis; Nuclear receptor co-regulator; Transcription, coactivator/corepressor B2RWS6 328572 15|15 E1 mouse S2276-p 486262 PAQPNPMsPQQHMLP phosphorylation transcription, induced 21498542 4 1 0 induces NFAT phosphorylation +Sptan1 SPTAN1 Adaptor/scaffold; Cytoskeletal; Motility/polarity/chemotaxis P16546 20740 2 B|2 20.93 cM mouse S1302-p 14828401 TAQRLIQsHPESAED Spectrin molecular association, regulation cell growth, altered 14-3-3 beta(INDUCES); NCAM1(INDUCES) 20598904 1 3 0 inhibits NCAM-stimulated neurite growth +Bach2 BACH2 DNA-binding; Transcription factor P97303 12014 4|4 A5 mouse K420-sm 2798316 PGPETLCkQEGELDR intracellular localization transcription, inhibited 15060166 2 0 0 formation of PML bodies +TNFAIP3 TNFAIP3 Apoptosis; DEUBIQUITINASE; EC 3.4.19.12; Protease; UBIQUITIN LIGASE; Ubiquitin conjugating system; Ubiquitin ligase P21580 7128 6q23.3 human S381-p 487535 EPSVPQLsLMDVKCE activity, induced; ubiquitination transcription, induced; signaling pathway regulation 17709380; 26649818; 31534238; 33154446 5 10 0 inhibit the NF-kB signaling pathway; regulates NF-kB signaling; cleavage of K63-linked tetraubiquitin ( all 4 sites or S381 alone), enhances ZnF4-mediated substrate ubiquitination; cell death inhibited (induces protective effect in A20-null cells); induces deubiquitination of its substrates +TRAF2 TRAF2 Autophagy; EC 6.3.2.-; Ligase; UBIQUITIN LIGASE; Ubiquitin conjugating system; Ubiquitin ligase Q12933 7186 9q34.3 human T117-p 471341 DGCTWKGtLKEYESC activity, induced 17188031 2 0 0 +Eif4ebp1 4E-BP1 Translation; Translation initiation Q62622 116636 16q12.3 rat S64-p 447527 FLMECRNsPVAKTPP eIF_4EBP molecular association, regulation translation, altered EIF4E(DISRUPTS) 10779345; 9806882 104 60 6 +PRKD3 PRKD3 EC 2.7.11.13; KINASE; Kinase, protein; Protein kinase, CAMK; Protein kinase, Ser/Thr (non-receptor) O94806 23683 2p22.2 human S735-p 456756 GEKSFRRsVVGTPAY Pkinase enzymatic activity, induced cell motility, induced 16198087; 24840177 2 46 52 Loss of Barbed End Formation for activities above basal level +CFLAR CFLAR Apoptosis O15519 8837 2q33.1 human T166-p 27811901 IHRIDLKtKIQKYKQ DED protein degradation; ubiquitination apoptosis, induced 23519470 2 1 0 concomitant sensitization of cancer cells to TRAIL-induced apoptosis; required for ROS-dependent degradation of CFLAR; mutation of T166, K167 or both ablates ROS-dependent CFLAR ubiquitination and degradation +SLC39A7 SLC39A7 Membrane protein, integral; Membrane protein, multi-pass; Transporter; Transporter, SLC family Q92504 7922 6p21.32 human S276-p 457020 STKEKQSsEEEEKET Zip activity, induced; phosphorylation exocytosis, induced; signaling pathway regulation 28205653; 31483418 2 19 9 maximal activation, SLC39A7 and Akt activation, zinc release and downstream effectors GSK3B, and p70 S6, phosphorylation of multiple kinases +Pag1 PAG Adaptor/scaffold; Membrane protein, integral Q9JM80 64019 2q23 rat Y381-p 463949 GEEPEPDyEAIQTLN PAG intracellular localization cytoskeletal reorganization; cell growth, altered 18498747; 19124084 3 16 90 +UPF1 RENT1 C2H2-type zinc finger protein; EC 3.6.1.-; EC 3.6.4.-; Hydrolase; RNA-binding Q92900 5976 19p13.11 human S1089-p 12559503 GLSQPELsQDSYLGD molecular association, regulation SMG7(INDUCES) 21965535 3 0 0 +CYLD CYLD DEUBIQUITINASE; EC 3.4.19.12; Protease; Tumor suppressor; Ubiquitin conjugating system; Ubiquitin-specific protease Q9NQC7 1540 16q12.1 human S772-p 31957308 LFKKIFPsLELNITD UCH enzymatic activity, induced 24614225 1 1 0 +RALB RALB G protein; G protein, monomeric; G protein, monomeric, Ras P11234 5899 2q14.2 human S198-p 16827200 KSSKNKKsFKERCCL intracellular localization carcinogenesis, altered; cell motility, altered; cytoskeletal reorganization; cell growth, altered 20940393 1 0 0 necessary for the development of experimental lung metastasis of human bladder cancer cells +HSP90AA1 HSP90A Chaperone; Heat shock protein P07900 3320 14q32.31 human Y197-p 459268 LKEDQTEyLEERRIK HSP90 molecular association, regulation; protein conformation CDK4(DISRUPTS); CDC37(DISRUPTS) 22727666; 23867252 2 7 178 phosphorylation induces altered conformation and governs drug specificity. +Nfatc1 NFAT2 DNA-binding; Transcription factor O88942 18018 18 E3|18 53.66 cM mouse S263-p 15412721 ARGSRPTsPCNKRKY intracellular localization; activity, inhibited cell differentiation, inhibited 31730830 2 7 16 +EHHADH EHHADH Amino Acid Metabolism - lysine degradation; Amino Acid Metabolism - tryptophan; Amino Acid Metabolism - valine, leucine and isoleucine degradation; Carbohydrate Metabolism - butanoate; Carbohydrate Metabolism - propanoate; EC 1.1.1.35; EC 4.2.1.17; EC 5.3.3.8; Isomerase; Lipid Metabolism - fatty acid; Lyase; Mitochondrial; Other Amino Acids Metabolism - beta-alanine; Oxidoreductase; Secondary Metabolites Metabolism - limonene and pinene degradation Q08426 1962 3q27.2 human K165-ac 14319820 ILADEALkLGILDKV ECH_1 enzymatic activity, induced 20167786 0 2 0 +MAD2L1 MAD2L1 Cell cycle regulation Q13257 4085 4q27 human S170-p 11280301 VPEKWEEsGPQFITN HORMA molecular association, regulation; protein conformation cell cycle regulation Mad1(DISRUPTS) 12574116; 21041666 2 0 0 +Nlrp3 NLRP3 Inhibitor Q8R4B8 216799 11|11 B1.3 mouse S3-p 38492201 _____MTsVRCKLAQ molecular association, regulation; activity, inhibited NLRP3(DISRUPTS); PYCARD(DISRUPTS) 34518217; 36872329 4 1 0 +CDC25B CDC25B EC 3.1.3.48; Motility/polarity/chemotaxis; Nuclear receptor co-regulator; PHOSPHATASE; Protein phosphatase, dual-specificity P30305 994 20p13 human S42-p 11452201 GSHGLLGsPVRAAAS cell growth, inhibited 25297629 1 4 0 induces immunogenicity, phospho-peptidesfor T-cell recognition showed some control of tumor growth in vivo +Ceacam1 CEACAM1 Cell adhesion; Immunoglobulin superfamily; Membrane protein, integral; Motility/polarity/chemotaxis P16573 81613 1q21 rat Y513-p 451429 SSPTETVySVVKKK_ activity, induced 7626603 5 2 37 Phosphorylation of CEACAM1 induces Ca2+/Mg2+-dependent ecto ATPase activity. +CETN2 CETN2 Calcium-binding; Cell cycle regulation; DNA repair, damage P41208 1069 Xq28 human T138-p 471512 KELGENLtDEELQEM EF-hand_7 molecular association, regulation XPC(DISRUPTS) 24918055 2 0 2 +HSPA1L HSPA1L Chaperone; Heat shock protein; Mitochondrial P34931 3305 6p21.33 human S241-p 1869383201 DFDNRLVsHFVEEFK HSP70 activity, induced apoptosis, inhibited; transcription, induced; signaling pathway regulation 31642047 1 0 0 induces chaperon activity of HSPA1L in vitro; heat stress-induced apoptosis +STK38 NDR1 EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, AGC; Protein kinase, Ser/Thr (non-receptor) Q15208 11329 6p21.31 human S91-p 1869478300 LGLEDFEsLKVIGRG Pkinase protein stabilization signaling pathway regulation 31690749 1 0 0 +USP16 USP16 DEUBIQUITINASE; EC 3.4.19.12; Protease; Ubiquitin conjugating system; Ubiquitin-specific protease Q9Y5T5 10600 21q21.3 human S386-p 50592104 HESFLDLsLPVLDDQ UCH enzymatic activity, induced 26323689 1 1 0 +HIP1 HIP1 Apoptosis; Cytoskeletal O00291 3092 7q11.23 human Y152-p 28704600 LLRTKMEyHTKNPRF ANTH cell growth, induced; apoptosis, inhibited 23836884 1 1 0 cell survival induced +FXN FXN EC 1.16.3.1; Mitochondrial; Motility/polarity/chemotaxis Q16595 2395 9q21.11 human Y118-p 41196502 EDLADKPyTFEDYDV Frataxin_Cyay ubiquitination 25948553 1 0 0 +MXD1 Mad1 DNA-binding; Transcription, coactivator/corepressor Q05195 4084 2p13.3 human S145-p 2807903 IERIRMDsIGSTVSS protein degradation; molecular association, regulation cell cycle regulation; transcription, induced; cell growth, altered DNA(INDUCES) 18451027; 19526459 2 0 0 inhibits MAD1-mediated transcription repression +Ola1 OLA1 EC 3.6.3.-; Hydrolase; Nucleolus Q9CZ30 67059 2|2 C3 mouse S232-p 1880539202 MVYLVNLsEKDYIRK protein stabilization; molecular association, regulation; ubiquitination; intracellular localization IMPA1(INDUCES) 36481055 1 1 0 inhibits ubiquitination +PPARG PPAR-gamma DNA-binding; Nuclear receptor; Transcription factor P37231 5468 3p25.2 human S112-p 448062 AIKVEPAsPPYYSEK sumoylation; protein degradation cell differentiation, altered; carcinogenesis, induced; signaling pathway regulation; transcription, inhibited; transcription, altered; cell growth, altered 11733495; 15507114; 16574647; 25409419; 26670611; 27687725; 34731634; 36139700; 37355990; 9030579; 9099735 33 7 0 +Irs2 IRS2 Adaptor/scaffold; Motility/polarity/chemotaxis P81122 384783 8 A1.1|8 5.35 cM mouse S1137-p 487314 QGGRRRHsSETFSST protein stabilization; molecular association, regulation transcription, induced 14-3-3 gamma(INDUCES) 23615913 1 9 27 +PKM PKM iso2 Carbohydrate Metabolism - glycolysis and gluconeogenesis; Carbohydrate Metabolism - pyruvate; EC 2.7.1.40; KINASE; Kinase, other; Mitochondrial; Nucleotide Metabolism - purine P14618-2 5315 15q23 human S37-p 476070 MCRLDIDsPPITARN enzymatic activity, inhibited; protein conformation 28607489 17 62 6 +Arap3 ARAP3 GAP; GAP, ARF; Motility/polarity/chemotaxis Q8R5G7 106952 18|18 B3 mouse Y1399-p 454957 DELEEPVyEEPVYEE cell motility, altered; cytoskeletal reorganization 15546919 3 0 0 +Fos Fos DNA-binding; Motility/polarity/chemotaxis; Oncoprotein; Transcription factor P12841 314322 6q31 rat T331-p 448484 CTPVVTCtPSCTTYT activity, induced; molecular association, regulation transcription, altered DNA(INDUCES) 17223854 4 0 0 +MYC Myc DNA-binding; Nucleolus; Oncoprotein; Transcription factor P01106 4609 8q24.21 human S267-p 466014 PPTTSSDsEEEQEDE Myc_N protein degradation; ubiquitination 22025562 2 0 0 S252 was the primary site for Myc degradation. +Aebp1 AEBP1 Secreted; Secreted, signal peptide; Transcription factor Q640N1 11568 11|11 A1 mouse T1003-p 455321 VDPSRPMtPQQRRMQ activity, induced transcription, inhibited 15654748 1 0 0 +DKFZp686G21220 DKFZp686G21220 Q6N090 human K109-ub 52490403 KDRINIIkDTSTNIV V-set protein degradation 26676607 0 1 0 +Itgb3 ITGB3 Cell adhesion; Membrane protein, integral; Motility/polarity/chemotaxis O54890 16416 11 E1|11 67.84 cM mouse Y784-p 448013 STFTNITyRGT____ Integrin_b_cyt molecular association, regulation; protein processing; activity, inhibited cell adhesion, altered SHC1(INDUCES) 10964917; 14519852; 16935858 21 2 6 +SLC9A3R1 NHERF Adaptor/scaffold; Motility/polarity/chemotaxis E2RGF3 dog S349-p 455753 RAHQKRSsKRAPQMD EBP50_C molecular association, regulation; intracellular localization; enzymatic activity, inhibited Ezrin(DISRUPTS); ARHGEF7(DISRUPTS) 22301917 5 1 12 Rac1 activity inhibited +Fos Fos DNA-binding; Motility/polarity/chemotaxis; Oncoprotein; Transcription factor P01101 14281 12 D2|12 39.7 cM mouse T232-p 448491 GGLPEAStPESEEAF activity, induced transcription, induced 8072547 6 0 0 +DICER1 DICER1 Cell development/differentiation; EC 3.1.26.3; Helicase; RNA processing; RNA-binding; Ribonuclease Q9UPY3 23405 14q32.13 human S1852-p 23098961 FSANVPRsPVRELLE DNA repair, induced 28642363 1 3 2 +CDT1 CDT1 DNA replication; DNA-binding; Motility/polarity/chemotaxis; Oncoprotein Q9H211 81620 16q24.3 human T402-p 20804634 PRPALPAtPPATPPA protein stabilization; molecular association, regulation; activity, inhibited; phosphorylation RAMP(DISRUPTS); MCM2(DISRUPTS) 21930785; 32841231 2 5 4 inhibits Chk1 phosphorylation +RNF7 RNF7 EC 6.3.2.-; Ligase; Motility/polarity/chemotaxis; UBIQUITIN LIGASE; Ubiquitin conjugating system; Ubiquitin ligase Q9UBF6 9616 3q23 human T10-p 449925 DVEDGEEtCALASHS protein degradation cell cycle regulation 12748192; 16874460 2 0 2 Phosphorylation of T10 of CKBBP1 is required for efficient degradation of I-kappa-B-alpha and P27/Kip1 +PHLPP1 PHLPP EC 3.1.3.16; PHOSPHATASE; Protein phosphatase, Ser/Thr (non-receptor); Tumor suppressor O60346 23239 18q21.33 human S335-p 15721886 PFVGGPVsSPRAPRP cell cycle regulation 33397691 1 4 0 +AATF AATF Nucleolus; RNA-binding; Transcription factor Q9NY61 26574 17q12 human S143-p 3753301 SKKSRSHsAKTPGFS protein stabilization; molecular association, regulation apoptosis, inhibited; transcription, altered NFkB-p65(INDUCES) DNA(INDUCES) 17157788 1 0 1 +MGMT MGMT Apoptosis; DNA repair, damage; EC 2.1.1.63; METHYLTRANSFERASE; Methyltransferase; Nuclear receptor co-regulator P16455 4255 10q26.3 human K165-ub 573761820 YSGGLAVkEWLLAHE DNA_binding_1 protein degradation 12036916 1 2 0 mutation of this site induces resistance to BG+BCNU chemotherapy by degradation inducing resynthesis of MGMT +Trpv1 TRPV1 Channel, cation; Membrane protein, integral; Membrane protein, multi-pass; Receptor, misc. O35433 83810 10q24 rat S116-p 454886 PRLYDRRsIFDAVAQ receptor desensitization, altered 12194871 6 1 0 +PRKAA1 AMPKA1 Autophagy; EC 2.7.11.1; EC 2.7.11.26; EC 2.7.11.27; EC 2.7.11.31; KINASE; Kinase, protein; Protein kinase, CAMK; Protein kinase, Ser/Thr (non-receptor) Q13131 5562 5p13.1 human S172-p 15407586 KIADFGLsNMMSDGE Pkinase activity, induced; enzymatic activity, induced carcinogenesis, inhibited; apoptosis, induced; apoptosis, inhibited; signaling pathway regulation 31679687; 33400734; 34418433; 35154579 8 1 4 +ACTA1 ACTA1 Cell development/differentiation; Contractile; Cytoskeletal; Motility/polarity/chemotaxis P68135 rabbit K52-ac 475524 VMVGMGQkDSYVGDE Actin activity, inhibited 30962575 1 6 58 CAP/actin inhibitory potency +Gch1 GCH1 Cofactor and Vitamin Metabolism - folate biosynthesis; EC 3.5.4.16; Hydrolase P22288 29244 15p14 rat T231-p 10428811 VFREDPKtREEFLTL GTP_cyclohydroI intracellular localization; enzymatic activity, inhibited 19762783 1 1 0 +STAT5A STAT5A DNA-binding; Motility/polarity/chemotaxis; Oncoprotein; Transcription factor P42229 6776 17q21.2 human Y694-p 447767 LAKAVDGyVKPQIKQ activity, induced; molecular association, regulation; intracellular localization carcinogenesis, induced; carcinogenesis, inhibited; cell growth, inhibited; apoptosis, induced; transcription, induced; signaling pathway regulation; transcription, altered; cell differentiation, induced; cell growth, induced; apoptosis, inhibited; transcription, inhibited STAT5A(DISRUPTS) DNA(DISRUPTS) 17726024; 18250158; 19088846; 21716071; 25885255; 31697835; 31932645; 34021045; 34188118; 35075244; 35154579; 36053753; 36460969 156 50 2180 +Dync1i2 DYNC1I2 Microtubule-binding; Motility/polarity/chemotaxis; Motor Q62871 116659 3q22 rat T95-p 469264 PSSKSVStPSEAGSQ intracellular localization cell cycle regulation 21507953 1 16 19 functions during prometaphase +HMGA1 HMGA1 DNA-binding P17096 3159 6p21.31 human S99-p 452256 KEEEEGIsQESSEEE cell growth, induced 29038488 3 64 173 +Was WASP Adaptor/scaffold; Motility/polarity/chemotaxis P70315 22376 X A1.1|X 3.65 cM mouse S501-p 449294 KRSRVIHsSDEGEDQ activity, induced cytoskeletal reorganization 24223520 2 10 0 +PML PML Nucleolus; Oncoprotein; SUMO LIGASE; SUMO conjugating system; SUMO ligase; Transcription factor; Tumor suppressor; Ubiquitin conjugating system P29590 5371 15q24.1 human K160-sm 2295400 EAHQWFLkHEARPLA zf-B_box protein degradation; molecular association, regulation; ubiquitination; intracellular localization; phosphorylation cell differentiation, inhibited; carcinogenesis, induced; cell differentiation, induced; transcription, induced; transcription, inhibited; cell growth, altered MDM2(DISRUPTS); PSME1(INDUCES); PIAS1(INDUCES); CK2A1(INDUCES); SUMO1(INDUCES); RNF4(INDUCES) 10779416; 11413191; 12759344; 12885887; 15710327; 17989716; 18408733; 19106612; 19380586; 20205709; 22406621; 23542129; 27099310; 27903803; 9756909 19 4 0 +CASP9 CASP9 Apoptosis; EC 3.4.22.62; Protease P55211 842 1p36.21 human Y251-p 1147026600 LQFPGAVyGTDGCPV Peptidase_C14 enzymatic activity, induced apoptosis, induced 29844931 1 0 0 +Relb RELB Transcription factor Q04863 19698 7 A3|7 9.93 cM mouse K274-ub 3055603 SEPVYDKkSTNTSEL transcription, induced 18620544 1 0 0 +ABCG2 ABCG2 Membrane protein, integral; Membrane protein, multi-pass; Transporter; Transporter, ABC family; Transporter, iron Q9UNQ0 9429 4q22.1 human T362-p 1818104 GEKKKKItVFKEISY activity, induced; molecular association, regulation; intracellular localization ABCG2(INDUCES) 18056989 2 0 0 drug resistance/efflux +TP53 p53 Activator; DNA-binding; Motility/polarity/chemotaxis; Nuclear receptor co-regulator; Transcription factor; Tumor suppressor P04637 7157 17p13.1 human K164-ac 2793003 VRAMAIYkQSQHMTE P53 activity, induced; acetylation; protein stabilization; molecular association, regulation; intracellular localization cell differentiation, induced; apoptosis, induced; transcription, induced; transcription, altered MDM2(DISRUPTS) 18485870; 19339993; 19377469; 21297583; 24038750; 25961455; 31680191; 33789902 12 1 0 recruit p300, CBP, and TIP60 onto PD-1 promoter, p53-mediated PD-1 transcription; 20, 164, 305, 320, 370/372/373, 381/382/386 K-R mutants diminsished transactivation, and selective regulation of target genes expression through distinct mechanisms +ENG ENG Membrane protein, integral; Motility/polarity/chemotaxis; Receptor, misc. P17813 2022 9q34.11 human T650-p 12064202 SIGSTQStPCSTSSM receptor internalization, induced; molecular association, regulation; phosphorylation signaling pathway regulation ARRB2(INDUCES) 22940691 2 0 0 TGF-beta-induced ITGB1 phosphorylation, integrin signaling and internalization +Cnn3 calponin 3 Cytoskeletal; Motility/polarity/chemotaxis Q9DAW9 71994 3|3 G1 mouse T288-p 34734351 IHNGSQGtGTNGSEI cell adhesion, induced; transcription, induced; cytoskeletal reorganization 31992794 1 0 7 induces formation of focal adhesions +Nfatc1 NFAT2 DNA-binding; Transcription factor O88942 18018 18 E3|18 53.66 cM mouse S243-p 4700879 PRHSPSTsPRASITE activity, inhibited transcription, inhibited 28920922 1 4 0 +TERF1 TRF1 DNA-binding P54274 7013 8q21.11 human S367-p 22996308 SRIPVSKsQPVTPEK protein degradation; molecular association, regulation; intracellular localization DNA(DISRUPTS) 22266654; 26586433 2 1 0 regulates telomere length and stability; lower telomere association across all phases of the cell cycle, elevated level of telomerase recruitment in G1 and G2/M phases +CBL CBL Adaptor/scaffold; EC 6.3.2.-; EC 6.3.2.19; Ligase; Motility/polarity/chemotaxis; Oncoprotein; UBIQUITIN LIGASE; Ubiquitin conjugating system; Ubiquitin ligase P22681 867 11q23.3 human S639-p 4704602 PDVPRLGsTFSLDTS molecular association, regulation 14-3-3 eta(INDUCES) 11024037 1 1 1 +Dusp4 DUSP4 EC 3.1.3.16; EC 3.1.3.48; PHOSPHATASE; Protein phosphatase, dual-specificity Q8BFV3 319520 8|8 A4 mouse S395-p 15412246 LHSPITTsPSC____ protein stabilization 22430215 2 1 2 +MAPK9 JNK2 EC 2.7.11.24; KINASE; Kinase, protein; Protein kinase, CMGC; Protein kinase, Ser/Thr (non-receptor) P45984 5601 5q35.3 human Y185-p 447652 TNFMMTPyVVTRYYR Pkinase cell cycle regulation; carcinogenesis, inhibited; apoptosis, induced; signaling pathway regulation 28068431; 35154579 75 39 1441 +CCNB1 CCNB1 Activator; Cell cycle regulation P14635 891 5q13.2 human S126-p 448814 PILVDTAsPSPMETS intracellular localization cell cycle regulation; carcinogenesis, induced DNA(INDUCES) 20117088; 22726437; 24582498; 24910099; 25849598 11 2 0 nuclear localization +EP300 p300 ACETYLTRANSFERASE; Acetyltransferase; EC 2.3.1.48; Motility/polarity/chemotaxis; Nuclear receptor co-regulator; Transcription, coactivator/corepressor Q09472 2033 22q13.2 human S2279-p 486262 PVQPNPMsPQQHMLP molecular association, regulation; enzymatic activity, induced transcription, altered SP1(NOT_REPORTED) 17623675 4 1 0 controls EGF-induced keratin 16 promoter activity ; regulates HAT activity of p300 +LIN28A LIN28A Nucleolus; RNA-binding; Translation Q9H9Z2 79727 1p36.11 human K177-ub 1883430201 MVASCPLkAQQGPSA protein degradation; molecular association, regulation 35262736 1 0 0 KAP1 binds to LIN28A and inhibits TRIM71 K177 ubiquitination and stabilizes LIN28A which may regulate let-7 miRNA levels +Nr1h3 LXR-alpha DNA-binding; Motility/polarity/chemotaxis; Nuclear receptor Q9Z0Y9 22259 2 E1|2 50.52 cM mouse K22-sm 1881122801 DSATELWkTEPQDAG protein degradation; ubiquitination 33125792 1 0 0 Sumoylation of LXR-alpha is necessary for polyubiquitylation and interaction with pSTAT1 and PIAS1 for degradation induced by IFN-gamma. May inhibit cholesterol effux mediated by ABCG1 from macrophages. +MDM2 MDM2 EC 6.3.2.-; EC 6.3.2.19; Inhibitor; Ligase; NEDDYLATION LIGASE; Neddylation Ligase; Nucleolus; Oncoprotein; UBIQUITIN LIGASE; Ubiquitin conjugating system; Ubiquitin ligase Q00987 4193 12q15 human Y394-p 455777 QSQESEDySQPSTSS apoptosis, induced; transcription, altered 12110584 2 0 0 +TRPC4 TRPC4 Channel, calcium; Membrane protein, integral; Membrane protein, multi-pass Q9UBN4 7223 13q13.3 human Y972-p 456714 DTVTHEDyVTTRL__ activity, induced; intracellular localization NHERF(INDUCES) 16144838 1 0 0 +KAT2B PCAF ACETYLTRANSFERASE; Acetyltransferase; EC 2.3.1.48; Nuclear receptor co-regulator Q92831 8850 3p24.3 human K441-ac 458987 SHVLEEAkKPRVMGD enzymatic activity, induced 12888487 1 0 0 in vitro +Cacng2 Stargazin Channel, calcium; Membrane protein, integral; Membrane protein, multi-pass O88602 12300 15 E1|15 36.92 cM mouse S228-p 455313 SAITRIPsYRYRYQR activity, induced; molecular association, regulation; intracellular localization neural plasticity ARC(DISRUPTS) 15664178; 20670832; 24882000; 25864631 5 1 2 regulates synaptic scaling +Dtna DTNA Motility/polarity/chemotaxis Q9D2N4 13527 18 A2|18 12.08 cM mouse Y705-p 1869344405 VPEDGDPyTQPEDGN protein stabilization; molecular association, regulation KAP(INDUCES) 32532815 1 0 0 +ESR1 ER-alpha DNA-binding; Nuclear receptor; Transcription factor P03372 2099 6q25.1-q25.2 human Y219-p 12620700 SIQGHNDyMCPATNQ zf-C4 protein stabilization; molecular association, regulation carcinogenesis, induced; cell growth, induced; transcription, induced; signaling pathway regulation ER-alpha(DISRUPTS) DNA(DISRUPTS) 20101225; 30692633 2 0 0 +Ncf1 p47phox EC 1.-.-.-; Oxidoreductase Q09014 17969 5 G2|5 74.47 cM mouse S346-p 451727 PGRPGPLsTDGTKDN intracellular localization 31438970 23 7 0 recruits NADPH oxidase to membranes +CDC25C CDC25C EC 3.1.3.48; Motility/polarity/chemotaxis; PHOSPHATASE; Protein phosphatase, dual-specificity P30307 995 5q31.2 human T67-p 448420 LSILSGGtPKRCLDL protein degradation; molecular association, regulation cell cycle regulation; cell adhesion, altered NEDD4(INDUCES); PIN1(INDUCES) 10037602; 20668692; 8119945 4 6 0 +MAPK14 P38A EC 2.7.11.24; KINASE; Kinase, protein; Protein kinase, CMGC; Protein kinase, Ser/Thr (non-receptor) Q16539 1432 6p21.31 human K53-ac 18575504 TGLRVAVkKLSRPFQ Pkinase molecular association, regulation; phosphorylation; enzymatic activity, induced apoptosis, induced Other(INDUCES) 21444723 1 1 0 induces ATP binding, induces phosphorylation of ATF2 +NUMB NUMB Cell development/differentiation P49757 8650 14q24.2-q24.3 human S7-p 487518 _MNKLRQsFRRKKDV intracellular localization endocytosis, induced; cell motility, induced AP2A1(DISRUPTS); PAR3(INDUCES); ITGB1(DISRUPTS) 17609107 2 3 1 +GABBR2 GABBR2 GPCR, family 3; Membrane protein, integral; Membrane protein, multi-pass; Receptor, GPCR O75899 9568 9q22.33 human K768-ub 54191603 QFTQNQKkEDSKTST protein degradation; ubiquitination 24114844; 26817839 2 0 0 +Nr3c1 GR DNA-binding; Mitochondrial; Nuclear receptor; Transcription factor P06536 24413 18p11 rat S287-p 3178938 TGDTILSsPSSVALP GCR intracellular localization transcription, induced 23878391 3 13 0 +Cnn3 calponin 3 Cytoskeletal; Motility/polarity/chemotaxis Q9DAW9 71994 3|3 G1 mouse S293-p 4776192 QGTGTNGsEISDSDY molecular association, regulation cell differentiation, induced; cytoskeletal reorganization ACTA1(INDUCES) 23276748 2 5 4 +TRPC5 TRPC5 Channel, cation; Membrane protein, integral; Membrane protein, multi-pass Q9UL62 7224 Xq23 human S796-p 20834808 GARAKSKsVSFNLGC intracellular localization; activity, inhibited signaling pathway regulation 21734191 1 0 0 +ETS1 Ets-1 DNA-binding; Motility/polarity/chemotaxis; Oncoprotein; Transcription factor P14921 2113 11q24.3 human S251-p 449316 GKLGGQDsFESIESY Ets1_N_flank molecular association, regulation; activity, inhibited transcription, inhibited DNA(DISRUPTS) 12475968 4 13 1 +ALDH1A1 ALDH1A1 Apoptosis; Cofactor and Vitamin Metabolism - retinol; EC 1.2.1.36; GAP; GAP, Ras; Oxidoreductase P00352 216 9q21.13 human T442-p 63070901 KDIDKAItISSALQA Aldedh protein stabilization; ubiquitination; intracellular localization; protein conformation; enzymatic activity, induced carcinogenesis, induced; cell motility, induced; cell growth, induced; transcription, induced ALDH1A1(DISRUPTS) 28193222 1 0 0 inhibits ubiquitination, induces drug resistance, T267 site ALDHA1A1 increases enzymatic activity, oligomers dissociate to the monomeric form +ASB2 ASB2 Unknown function Q96Q27 51676 14q32.12 human S371-p 29618900 RIRRSGVsPLHLAAE Ank_2 protein degradation; intracellular localization 24044920 1 1 0 Localization with and degradation of FLNa +FBP1 FBPase Carbohydrate Metabolism - fructose and mannose; Carbohydrate Metabolism - glycolysis and gluconeogenesis; Carbohydrate Metabolism - pentose phosphate pathway; EC 3.1.3.11; Mitochondrial; Phosphatase (non-protein) P09467 2203 9q22.32 human K113-ac 1876844500 VEPEKRGkYVVCFDP FBPase molecular association, regulation carcinogenesis, inhibited; transcription, inhibited BRD4(INDUCES) 32195024 1 0 0 +WRN WRN Cell cycle regulation; DNA repair, damage; DNA-binding; EC 3.6.4.12; Helicase; Nucleolus Q14191 7486 8p12 human S467-p 3196124 DTSYVIEsDEDLEME intracellular localization DNA repair, induced 24429382 1 14 2 localization to nucleoli, protection of cells from DSBs produced by etoposide +Cd5 CD5 Cell surface; Membrane protein, integral P13379 12507 19 A|19 7.16 cM mouse Y486-p 447775 DNSSDSDyDLQVAQR molecular association, regulation PIK3R1(NOT_REPORTED) 9079809 5 2 89 +Mapk1 ERK2 EC 2.7.11.24; KINASE; Kinase, protein; Protein kinase, CMGC; Protein kinase, Ser/Thr (non-receptor) P63086 116590 11q23 rat T183-p 447593 HDHTGFLtEYVATRW Pkinase activity, induced; molecular association, regulation; intracellular localization; enzymatic activity, induced translation, altered; cytoskeletal reorganization; cell adhesion, altered; signaling pathway regulation; cell growth, altered MEK1(INDUCES) 10473611; 10567369; 11731096; 12163549; 12595539; 12876277; 14627993; 15757502; 16368189; 19427337; 19943942; 20096547; 21357465; 21660950; 21738764; 21917714; 8444886 1139 120 2416 quercetin and myricetin-induced cardioprtection signaling; regulate cell proliferation in dentate gyrus following ischemia; phenylphrine induces protein synthesis; activation of MEK1 and ERK1/2; Arginine methyltransferase 5 induced signaling for cell proliferation and differentiation; focal adhesion inhibition/dissociation; integrin Rac1-NADPH oxidase signaling +HSD17B4 HSD17B4 Cell development/differentiation; EC 1.1.1.n12; EC 4.2.1.107; EC 4.2.1.119; Lipid Metabolism - primary bile acid biosynthesis; Lyase; Mitochondrial; Oxidoreductase P51659 3295 5q23.1 human K669-ac 461239 AKWTIDLkSGSGKVY SCP2 protein degradation carcinogenesis, inhibited; autophagy, induced 28296597; 32678070 2 4 1 +LSM4 LSM4 RNA-binding; Spliceosome Q9Y4Z0 25804 19p13.11 human R115-m2 60203700 GRGVFGGrGRGGIPG molecular association, regulation SMN(INDUCES) 11720283 1 1 0 +Htr2c 5-HT(2C) GPCR, family 1; Membrane protein, integral; Membrane protein, multi-pass; Receptor, GPCR P08909 25187 Xq34 rat S458-p 449090 NVVSERIsSV_____ molecular association, regulation; receptor desensitization, altered MPDZ(DISRUPTS) 10816555; 12682077 2 0 0 +CDK9 CDK9 Cell cycle regulation; EC 2.7.11.22; EC 2.7.11.23; KINASE; Kinase, protein; Nuclear receptor co-regulator; Protein kinase, CMGC; Protein kinase, Ser/Thr (non-receptor) P50750 1025 9q34.11 human Y19-p 1880104202 FCDEVSKyEKLAKIG protein stabilization; molecular association, regulation; intracellular localization; phosphorylation; enzymatic activity, induced carcinogenesis, induced; DNA repair, induced; cell growth, induced; transcription, induced SKP2(DISRUPTS) 36253486 1 0 0 +EXO1 EXO1 EC 3.1.-.-; Hydrolase Q9UQ84 9156 1q43 human S454-p 1240800 SEGNKSLsFSEVFVP protein degradation 18048416 1 2 0 +Dlg4 PSD-95 Adaptor/scaffold P31016 29495 10q24 rat S73-p 471390 ITLERGNsGLGFSIA PDZ molecular association, regulation; intracellular localization; activity, inhibited cell growth, altered NMDAR2A(DISRUPTS) 17156196; 19081375 6 4 0 enhances trafficking of SHANK2 and PSD-95 itself +Icos ICOS Membrane protein, integral Q9WVS0 54167 1 C2|1 30.6 cM mouse Y181-p 21511702 VHDPNSEyMFMAAVN molecular association, regulation PIK3CB(INDUCES); PIK3CD(INDUCES); PIK3R1(INDUCES); PIK3CA(INDUCES) 21188463 1 0 1 +SMARCA4 SMARCA4 Cell cycle regulation; EC 3.6.1.-; EC 3.6.4.-; Helicase; Nuclear receptor co-regulator; Transcription, coactivator/corepressor; Tumor suppressor P51532 6597 19p13.2 human K1033-ac 11317281 KKGKGGTkTLMNTIM SNF2-rel_dom DNA repair, induced; chromatin organization, altered 31291457 1 2 0 recruitment of SIRT1 is required for clearing nucleosomes and promoting HR at DNA DSB sites +CSF1R CSFR EC 2.7.10.1; KINASE; Kinase, protein; Membrane protein, integral; Oncoprotein; Protein kinase, TK; Protein kinase, tyrosine (receptor) P07333 1436 5q32 human Y723-p 448364 SSQGVDTyVEMRPVS PK_Tyr_Ser-Thr molecular association, regulation CBL(INDUCES) 10648820 15 0 1 +GLS glutaminase Amino Acid Metabolism - alanine, aspartate and glutamate; Amino Acid Metabolism - arginine and proline; EC 3.5.1.2; Energy Metabolism - nitrogen; Hydrolase; Mitochondrial; Other Amino Acids Metabolism - D-Glutamine and D-glutamate O94925 2744 2q32.2 human K164-sc 33361123 HKFITALkSTGLRTS EF-hand_14 protein degradation; protein stabilization; ubiquitination; succinylation carcinogenesis, inhibited; autophagy, induced; cell growth, inhibited 30910998; 31843902 2 1 0 suppresses its Lys48-linked ubiquitination; SIRT5 downregulated +NDEL1 NDEL1 Microtubule-binding; Protease Q9GZM8 81565 17p13.1 human T219-p 468252 ASLSLPAtPVGKGTE NUDE_C molecular association, regulation; intracellular localization PAFAH1B1(INDUCES); DYNC1I1(INDUCES) 12556484; 37086789 6 15 3 +SLC9A5 NHE5 Membrane protein, integral; Membrane protein, multi-pass; Transporter; Transporter, SLC family Q14940 6553 16q22.1 human S711-p 20832303 EEEEESDsSETEKED molecular association, regulation; activity, inhibited endocytosis, induced ARRB1(INDUCES) 21296876 1 0 0 +Keap1 KEAP1 Endoplasmic reticulum; Motility/polarity/chemotaxis; Transcription regulation; UBIQUITIN LIGASE; Ubiquitin conjugating system Q9Z2X8 50868 9|9 A3 mouse Y141-p 2708401 ERLIEFAyTASISVG BTB protein stabilization transcription, altered 18434303 1 0 0 INrf2 Y141A mutant fails to degrade Nrf2 +FGD1 FGD1 GEF; GEF, misc. P98174 2245 Xp11.22 human S205-p 3193805 LAPRAEAsPSSAAVS cell motility, altered 21212517 2 2 0 +CCP110 CP110 Cell cycle regulation O43303 9738 16p12.3 human S170-p 22351338 RDSEGFNsPKQCDSS intracellular localization cell cycle regulation 12361598 2 10 1 +LAT LAT iso2 Adaptor/scaffold; Membrane protein, integral O43561-2 27040 16p11.2 human Y132-p 447760 DDYHNPGyLVVLPDS LAT activity, induced; protein degradation; molecular association, regulation; ubiquitination; enzymatic activity, induced; phosphorylation cell differentiation, altered; signaling pathway regulation; transcription, altered GRB2(INDUCES); PLCG1(INDUCES); GADS(INDUCES); PLCG2(INDUCES) 11395491; 12496416; 24412752; 24642916; 27221712; 30510001; 34161759; 35124007 24 1 1 induces Erk and calcium signaling +OSBP OSBP Lipid-binding P16258 rabbit S195-p 452648 MLAESDEsGDEESVS molecular association, regulation; intracellular localization VAPA(INDUCES) 22875984 1 78 10 regulation of Sphingomyelin synthesis. S381A/S3D mutant has enhanced binding and altered localization +ROCK2 ROCK2 EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, AGC; Protein kinase, Ser/Thr (non-receptor) O75116 9475 2p25.1 human S1366-p 23003812 ARSSPRTsMKIQQNQ enzymatic activity, induced 22273145; 24168723 4 4 0 +RPL11 RPL11 Motility/polarity/chemotaxis; Nucleolus; Ribosomal; Translation P62913 6135 1p36.11 human K118-ne 12067611 EHIDLGIkYDPSIGI Ribosomal_L5_C protein stabilization; intracellular localization 19713960 1 0 0 +Elavl1 HuR RNA-binding P70372 15568 8 A1.1|8 2.0 cM mouse S318-p 2246702 GDKILQVsFKTNKSH molecular association, regulation translation, induced MYH9(INDUCES) 23921630 8 3 0 association is RNA dependent; Ang II mediated recruitment to polysomes +E2F4 E2F4 DNA-binding E1BUH4 chicken T263-p 25571900 STQPSTPtPSSTQDH cell cycle regulation; apoptosis, induced 22586272 1 0 0 +ABI1 Abi-1 Adaptor/scaffold; Motility/polarity/chemotaxis Q8IZP0 10006 10p12.1 human Y213-p 449523 PPTVPNDyMTSPARL protein degradation; molecular association, regulation; ubiquitination carcinogenesis, inhibited; endocytosis, altered; signaling pathway regulation PIK3R1(INDUCES) 20598684; 35839699 5 42 680 inhibits PI3K/Akt and Lyn pathways +Nek3 NEK3 EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, Other; Protein kinase, Ser/Thr (non-receptor) Q9R0A5 23954 8 A2|8 11.07 cM mouse T477-p 454368 PRLDEEDtDFEEDNE acetylation cytoskeletal reorganization 19509051 1 26 12 regulates neuronal morphology and polarity; regulates the level of alpha-tubulin acetylation (Ac-tubulin) +UBA2 SAE2 EC 6.3.2.-; EC 6.3.2.19; Ligase; Motility/polarity/chemotaxis; SUMO LIGASE; SUMO conjugating system; SUMO ligase; UBIQUITIN LIGASE; Ubiquitin conjugating system; Ubiquitin ligase Q9UBT2 10054 19q13.11 human K611-sm 27851103 SEEERSRkRKLDEKE UBA2_C intracellular localization 23095757 1 1 0 nuclear localization +DPYSL2 CRMP-2 iso3 Microtubule-binding; Motility/polarity/chemotaxis NP_001184222 1808 8p21.2 human S627-p 448082 PASSAKTsPAKQQAP protein stabilization; molecular association, regulation carcinogenesis, altered; cell growth, induced; cell motility, altered PIN1(INDUCES) 24036111; 26489457 31 49 84 axon growth in vitro +SFPQ PSF Nuclear receptor co-regulator; RNA splicing; RNA-binding P23246 6421 1p34.3 human Y293-p 482843 RRPGEKTyTQRCRLF intracellular localization transcription, altered; cell growth, altered RNA(INDUCES) 17537995 1 1 0 relocalization from nucleus to cytoplasm +TP63 p63 iso2 DNA-binding; Transcription factor Q9H3D4-2 8626 3q28 human S68-p 451601 TFDALSPsPAIPSNT protein degradation cell growth, inhibited 23166821; 30301786 6 2 0 Anti-clonogenic effects of TGFB require S66,68 phosphorylation. +Terf2 TRF2 DNA repair, damage; DNA-binding O35144 21750 8 D3|8 53.59 cM mouse S367-p 452842 ANLASPSsPAHKHKR molecular association, regulation cell cycle regulation RTEL1(DISRUPTS) 31723267 3 66 94 +TARDBP TDP-43 RNA-binding Q13148 23435 1p36.22 human S409-p 3084616 GSSMDSKsSGWGM__ molecular association, regulation; ubiquitination; intracellular localization; activity, inhibited; protein conformation; phosphorylation RNA splicing, induced; autophagy, induced; apoptosis, induced; RNA stability, inhibited; autophagy, altered; transcription, inhibited TDP-43(INDUCES); TDP-43(DISRUPTS) 19164285; 19515851; 21062285; 22198567; 24105464; 24466128; 24595055; 27445339; 28599005; 29311743; 29623031; 29987190; 30120199; 30559480; 34107054; 35112738 54 4 0 inhibited mTOR activity and dynactin expression, induced neuronal injury; primes phosphorylation at other sites; phosphomimetic S410/409D mutant reduces TARDBP aggregation and autophagy; induces cytotoxicity and oligomerization; promotes cytoplasmic aggregation +PTPRC CD45 EC 3.1.3.48; Membrane protein, integral; Motility/polarity/chemotaxis; PHOSPHATASE; Receptor protein phosphatase, tyrosine P08575 5788 1q31.3-q32.1 human Y1218-p 451644 MVSTFEQyQFLYDVI Y_phosphatase activity, induced; molecular association, regulation Lck(INDUCES) 7507203 1 0 1 +MCL1 MCL1 Apoptosis; Channel, misc.; Inhibitor; Membrane protein, integral; Mitochondrial Q07820 4170 1q21.2 human K40-ub 4953909 GRLLATEkEASARRE protein degradation apoptosis, inhibited 28522751; 30718431 2 7 41 DUB3-MCL1 drives chemoresistance in Ovarian Cancer via inhibition of apoptosis; HDACis and PaTrin-2 led to the ideal therapeutic effect +CASP3 CASP3 Apoptosis; EC 3.4.22.56; Motility/polarity/chemotaxis; Protease P42574 836 4q35.1 human S249-p 866032500 KVATEFEsFSFDATF Peptidase_C14 enzymatic activity, inhibited 29414778 1 0 0 +NCBP1 NCBP1 RNA processing; Spliceosome; Translation Q09161 4686 9q22.33 human S7-p 9764056 _MSRRRHsDENDGGQ RNA splicing, altered 10973943 1 20 17 +IL1R1 IL-1RA EC 2.7.11.25; Membrane protein, integral; Receptor, cytokine P14778 3554 2q11.2-q12.1 human Y496-p 450889 ELEKIQDyEKMPESI TIR molecular association, regulation PIK3R1(INDUCES) 9821957 1 0 0 +Camk2b CAMK2B EC 2.7.11.17; KINASE; Kinase, protein; Protein kinase, CAMK; Protein kinase, Ser/Thr (non-receptor) P08413 24245 14q21 rat S371-p 2020829 AITSPKGsLPPAALE molecular association, regulation cytoskeletal reorganization ACTB(DISRUPTS) 24866099; 26291163 2 5 0 inhibits interaction with F-actin, regulates synaptic plasticity; Transient phosphorylation promotes oligodendrocyte maturation. +GYS1 GYS1 Carbohydrate Metabolism - starch and sucrose; EC 2.4.1.11; Transferase P13834 100008660 rabbit S11-p 451605 SRTLSVSsLPGLEDW enzymatic activity, inhibited 10909964; 7929255 10 2 1 simultaneous mutation of both NH2- and COOH-terminal sites was necessary to cause substantial increases in the activity ratio. +SULT4A1 SULT4A1 EC 2.8.2.-; Transferase Q9BR01 25830 22q13.31 human T8-p 2021049 MAESEAEtPSTPGEF protein degradation; molecular association, regulation PIN1(INDUCES) 19439498; 20920535 2 1 0 +Mecp2 MECP2 Transcription, coactivator/corepressor Q9Z2D6 17257 X A7.3|X 37.63 cM mouse S421-p 470075 EKMPRGGsLESDGCP molecular association, regulation; intracellular localization neural plasticity; chromatin organization, altered; transcription, induced; cytoskeletal reorganization; transcription, inhibited DNA(DISRUPTS) 21765426; 21982370; 33551790; 34183865 15 13 0 +RRAS2 RRas2 G protein; G protein, monomeric; G protein, monomeric, Ras; Motility/polarity/chemotaxis; Oncoprotein P62070 22800 11p15.2 human S186-p 484150 QEQECPPsPEPTRKE carcinogenesis, induced 27086924 1 76 1 +YAP1 YAP1 iso2 Oncoprotein; Transcription, coactivator/corepressor P46937-2 10413 11q22.1 human S138-p 485036 SLQLGAVsPGTLTPT molecular association, regulation apoptosis, inhibited; transcription, induced TEAD1(INDUCES) 22308035 4 30 79 YAP phosphorylation is required for anti-apoptotic activity of YAP in cells which are deficient in p73 alpha/beta expression. +GAB1 GAB1 Adaptor/scaffold; Motility/polarity/chemotaxis Q13480 2549 4q31.21 human Y373-p 447945 ASDTDSSyCIPTAGM molecular association, regulation CDK6(INDUCES) 19881549 6 15 279 promotes HGF-induced DNA synthesis +LATS2 LATS2 EC 2.7.11.1; KINASE; Kinase, protein; Nuclear receptor co-regulator; Protein kinase, AGC; Protein kinase, Ser/Thr (non-receptor); Tumor suppressor Q9NRM7 26524 13q12.11 human S380-p 3213669 ATLARRDsLQKPGLE intracellular localization 21822051 2 13 9 chromosome segregation and cytokinesis ; translocation from the centrosome to the chromosome and spindle during mitosis +Stmn2 STMN2 Cytoskeletal P55821 20257 3 A1|3 2.15 cM mouse S62-p 450174 ELILKPPsPISEAPR Stathmin protein degradation cell motility, altered; cytoskeletal reorganization 21297631; 24469251 9 11 0 Phosphorylated SCG10 accumulates in THC-treated neurons after proteasomal inhibition.; phospho-mimetic S62D/S73D mutant stabilizes microtubules +TUBA1B TUBA1B Cytoskeletal; Motility/polarity/chemotaxis P68363 10376 12q13.12 human K40-m3 125970000 DGQMPSDkTIGGGDD Tubulin cell cycle regulation; cytoskeletal reorganization 27518565 2 1 0 +WDCP WDCP Q9H6R7 80304 2p23.3 human S686-p 3212568 RSDVFRDsFSHSPGA molecular association, regulation KIF2A(DISRUPTS); MRE11A(INDUCES) 30297404 1 7 1 mitotic spindle dynamics +Msx1 MSX1 DNA-binding; Motility/polarity/chemotaxis P13297 17701 5 B3|5 20.21 cM mouse K15-sm 12004422 TSLPLGVkVEDSAFA cell differentiation, inhibited; transcription, inhibited 16600910 2 1 0 PIAS1 binding to MSX1 is required for inhibiting cell differentiation and transcriptional repression, but sumoylation is not required +FLT4 VEGFR3 EC 2.7.10.1; KINASE; Kinase, protein; Membrane protein, integral; Protein kinase, TK; Protein kinase, tyrosine (receptor) P35916 2324 5q35.3 human Y1063-p 473000 FGLARDIyKDPDYVR PK_Tyr_Ser-Thr molecular association, regulation; enzymatic activity, induced apoptosis, inhibited SHC1(INDUCES); CRK(INDUCES) 16076871; 20431062 2 4 105 +CTTN Cortactin Actin-binding; Cytoskeletal; Motility/polarity/chemotaxis Q14247 2017 11q13.3 human S298-p 5014901 EKLAKHEsQQDYSKG HS1_rep molecular association, regulation; phosphorylation cell motility, altered; cytoskeletal reorganization; cell adhesion, inhibited 14-3-3 beta(INDUCES); CTNNB1(DISRUPTS); Vinculin(DISRUPTS) 19038333; 20363754; 27179075; 31727638 6 9 1 +IRS1 IRS1 Adaptor/scaffold; Motility/polarity/chemotaxis P35568 3667 2q36.3 human K1186-ub 1873529901 YIDLDLVkDFKQCPQ molecular association, regulation; phosphorylation cell growth, induced; signaling pathway regulation IGF1R(INDUCES) 33991522 1 0 0 regulates IRS1-tyrosine phosphorylation and IGF1-mediated downstream signaling +CDC42 CDC42 G protein; G protein, monomeric; G protein, monomeric, Rho; Motility/polarity/chemotaxis P60953 998 1p36.12 human K166-ub 12294209 ALTQKGLkNVFDEAI Ras protein degradation; molecular association, regulation carcinogenesis, inhibited; cell growth, inhibited; cytoskeletal reorganization PAK6(DISRUPTS) 28661476 1 3 6 +Kcnk2 TREK-1 Channel, potassium; Membrane protein, integral; Membrane protein, multi-pass P97438 16526 1|1 H6 mouse S315-p 456160 GDWLRVIsKKTKEEV activity, induced; activity, inhibited 16006563; 17916432; 22728824 4 0 0 +CHRM1 mAChR m1 GPCR, family 1; Membrane protein, integral; Membrane protein, multi-pass; Receptor, GPCR P11229 1128 11q12.3 human S273-p 54066607 PRLLQAYsWKEEEEE 7tm_1 molecular association, regulation ARRB1(INDUCES) 28652372 2 1 0 followed by arrestin-dependent ERK phosphorylation +SP3 SP3 C2H2-type zinc finger protein; DNA-binding Q02447 6670 2q31.1 human K551-sm 2407419 SPADIRIkEEEPDPE intracellular localization; activity, inhibited transcription, inhibited 12419227; 15247228; 15494207 3 3 0 +Ptpn6 SHP-1 EC 3.1.3.48; Motility/polarity/chemotaxis; PHOSPHATASE; Protein phosphatase, tyrosine (non-receptor) P81718 116689 4q42 rat Y538-p 448506 QRGQESEyGNITYPP molecular association, regulation PIK3R1(INDUCES) 9452499 20 24 637 +SH2D2A TSAd Adaptor/scaffold Q9NP31 9047 1q23.1 human Y305-p 450668 GEAPSNIyVEVEDEG molecular association, regulation Lck(INDUCES) 18541536 1 4 38 +Rictor RICTOR Adaptor/scaffold; Cell cycle regulation; Ubiquitin conjugating system Q6QI06 78757 15|15 A1 mouse T1135-p 458276 NRRIRTLtEPSVDLN RICTOR_phospho autophagy, inhibited; transcription, inhibited 34706731 11 14 173 +F3 F3 Cell surface; Membrane protein, integral P13726 2152 1p21.3 human K287-ub 15398676 AGVGQSWkENSPLNV ubiquitination; phosphorylation endocytosis, induced 27599717 1 3 2 +Pparg PPAR-gamma DNA-binding; Nuclear receptor; Transcription factor P37238 19016 6 E3|6 53.41 cM mouse Y78-p 36692605 SSISAPHyEDIPFTR PPARgamma_N cell motility, altered 26385316 2 1 0 suppresses the secretion of cytokines and chemokines from adipocytes +IRF8 IRF8 DNA-binding; Transcription factor Q02556 3394 16q24.1 human S151-p 1878257200 DELIKEPsVDDYMGM molecular association, regulation; phosphorylation cell cycle regulation; transcription, induced STING(INDUCES) 35973990 1 0 0 induces STING phosphorylation +TXN TXN Nuclear receptor co-regulator P10599 7295 9q31.3 human T76-p 28716000 CEVKCMPtFQFFKKG Thioredoxin protein degradation; ubiquitination; enzymatic activity, inhibited apoptosis, inhibited; transcription, inhibited; signaling pathway regulation 23747528 1 1 0 MPK38-mediated signaling through TGF-B, ASK1 and p53 +MAPK1 ERK2 EC 2.7.11.24; KINASE; Kinase, protein; Protein kinase, CMGC; Protein kinase, Ser/Thr (non-receptor) P28482 5594 22q11.22 human S29-p 7989100 GPRYTNLsYIGEGAY Pkinase molecular association, regulation; enzymatic activity, induced MEK2(INDUCES); MEK1(INDUCES) 19447520 1 0 0 +FANCD2 FANCD2 DNA repair, damage Q9BXW9 2177 3p25.3 human S64-p 1883582904 IILKTGEsQNQLAVD activity, induced; molecular association, regulation; ubiquitination; intracellular localization signaling pathway regulation DNA(INDUCES) 37392383 1 1 0 regulates the FA pathway +NEDD1 NEDD1 Cell cycle regulation Q8NHV4 121441 12q23.1 human S325-p 15421692 PTTVNKRsVNVNAAS molecular association, regulation cell cycle regulation TUBG1(DISRUPTS); SAS6(INDUCES) 33351100 2 5 3 regulation of cartwheel assembly and centriole biogenesis +Stat3 STAT3 DNA-binding; Motility/polarity/chemotaxis; Nuclear receptor co-regulator; Transcription factor P42227 20848 11 D|11 63.82 cM mouse K709-ac 7440601 AAPYLKTkFICVTPT acetylation; phosphorylation transcription, inhibited SIRT1(INDUCES) 19295512 1 1 0 SIRT1 downregulates phosphorylation at STAT3-Y705 and transactivation, deacetylation of STAT3 +SLC7A5 SLC7A5 Membrane protein, integral; Membrane protein, multi-pass; Transporter; Transporter, SLC family Q01650 8140 16q24.2 human K19-ub 6778621 AAPAAEEkEEAREKM protein degradation endocytosis, induced 31728037 1 10 36 PMA-induced endocytosis +CASP9 CASP9 Apoptosis; EC 3.4.22.62; Protease P55211 842 1p36.21 human Y397-p 286046008 AVSVKGIyKQMPGCF Peptidase_C14 enzymatic activity, inhibited 29066624 1 1 0 +Tiam1 TIAM1 GEF; GEF, Rac/Rho; Motility/polarity/chemotaxis; Oncoprotein Q60610 21844 16 C3.3|16 51.5 cM mouse Y829-p 465610 PQPEEDIyELLYKEI RBD cytoskeletal reorganization 16801538 2 0 0 important for BDNF-induced neurite outgrowth +DOCK7 DOCK7 GEF; GEF, misc. Q96N67 85440 1p31.3 human Y1257-p 2756301 METVPQLyDFTETHN molecular association, regulation; activity, inhibited carcinogenesis, inhibited; cell motility, altered; cell motility, inhibited BIN3(INDUCES) 18426980; 27018747; 35915159 3 0 0 +RBM17 RBM17 RNA splicing; RNA-binding; Spliceosome Q96I25 84991 10p15.1 human S204-p 476471 DSRPRSQsSKAAIPP molecular association, regulation; phosphorylation cell motility, induced; RNA stability, induced RNA(DISRUPTS) 23519612 1 1 0 induced cell invasion, enhanced Cortactin phosphorylation at ERK-dependent sites +Flt4 VEGFR3 EC 2.7.10.1; KINASE; Kinase, protein; Membrane protein, integral; Protein kinase, TK; Protein kinase, tyrosine (receptor) P35917 14257 11 B1.2|11 29.69 cM mouse Y1337-p 2874406 KVFYNNEyGEVSQPC cell growth, altered 7675451 4 1 2 +Ibsp Sialoprotein-2 Cell adhesion; Motility/polarity/chemotaxis; Secreted; Secreted, signal peptide P13839 rat S153-p 457545 KAPKMKEsDEEEEEE BSP_II activity, induced 20377527 2 2 0 important for hydroxyapatite (HA) nucleation +ARHGAP35 GRF-1 GAP; GAP, Rac/Rho; Motility/polarity/chemotaxis; Transcription factor; Tumor suppressor Q9NRY4 2909 19q13.32 human S1174-p 7157500 RFASYRTsFSVGSDD RhoGAP_pG1_pG2 molecular association, regulation; activity, inhibited RND1(DISRUPTS) 19103606 1 5 0 +Kifap3 KIFAP3 Adaptor/scaffold P70188 16579 1|1 H2.1 mouse S60-p 4711034 QKIIRLKsLNANTDI KAP molecular association, regulation; intracellular localization; phosphorylation cell differentiation, inhibited; cytoskeletal reorganization TRIM46(DISRUPTS) 31461655 1 37 13 primes phosphorylation at other sites +RAB3IP RAB3IP GEF; GEF, Rab Q96QF0 117177 12q15 human S288-p 4734219 KGHTRNKsTSSAMSG molecular association, regulation; intracellular localization cytoskeletal reorganization EXOC6(INDUCES) 23435566 2 18 0 inhibits binding to phosphatidylserine; ciliogenesis +ATF7 ATF7 C2H2-type zinc finger protein; DNA-binding; Transcription factor P17544 11016 12q13.13 human T51-p 467515 SVIIADQtPTPTRFL activity, induced; protein degradation; sumoylation; molecular association, regulation; ubiquitination transcription, induced; signaling pathway regulation TAF12(INDUCES) 18950637; 21858082 2 50 37 +Mef2c MEF2C DNA-binding; Transcription factor Q8CFN5 17260 13 C3|13 43.68 cM mouse S98-p 23068100 KGLNGCDsPDPDADD HJURP_C molecular association, regulation PIN1(INDUCES) 20801874 1 8 4 Pin1 binding decreases MEF2C stability and its transcriptional activity +Npm1 NPM1 Nucleolus; Oncoprotein; RNA-binding; Translation Q61937 18148 11|11 A4 mouse T95-p 456130 SLGGFEItPPVVLRL Nucleoplasmin protein conformation 24616519 2 18 18 +IL4R IL4R Membrane protein, integral; Receptor, cytokine P24394 3566 16p12.1 human Y713-p 451066 SLGSGIVySALTCHL molecular association, regulation apoptosis, inhibited; cell growth, altered SHIP(INDUCES) 11714803; 9670964 2 0 0 +GJA1 GJA1 Channel, misc.; Membrane protein, integral; Membrane protein, multi-pass; Motility/polarity/chemotaxis P17302 2697 6q22.31 human S373-p 459209 RASSRASsRPRPDDL activity, induced; molecular association, regulation; intracellular localization; protein conformation ZO1(DISRUPTS); ITGA5(INDUCES) 23828237; 24213533; 24563481; 29259079 19 7 0 gap junction communication; trophoblast cell fusion and syncytial hormone production; assembly of Cx43 at the plasma membrane +MXI1 Mad2 DNA-binding; Oncoprotein P50539 4601 10q25.2 human S195-p 1876620102 HGEVDNIsTTSISDI molecular association, regulation cell cycle regulation; carcinogenesis, inhibited; DNA repair, inhibited Mad1(INDUCES); CDC20(DISRUPTS) 35309941 1 0 0 +PIN1 PIN1 EC 5.2.1.8; Isomerase; Nuclear receptor co-regulator Q13526 5300 19p13.2 human S115-p 1873647702 SQFSDCSsAKARGDL Rotamase protein stabilization; ubiquitination carcinogenesis, induced; cell growth, induced; transcription, induced 34048060 1 1 0 inhibits ubiquitination (PIN1 mono-ubiquitination at Lys117 ) +Srebf1 SREBP-1 iso4 DNA-binding; Membrane protein, integral; Membrane protein, multi-pass; Transcription factor Q9WTN3-4 20787 11|11 B2 mouse S266-p 458357 IEKRYRSsINDKIVE HLH molecular association, regulation transcription, altered DNA(DISRUPTS) 19244231 4 1 0 regulates hepatic lipogenesis +IRX2 IRX2 DNA-binding; Transcription factor Q9PU52 373975 chicken S65-p 452192 AAATGFTsPLQYSTD transcription, altered 15133517 1 0 0 +PRKN PARK2 EC 6.3.2.-; EC 6.3.2.19; Ligase; Translation; Translation regulation; UBIQUITIN LIGASE; Ubiquitin conjugating system; Ubiquitin ligase O60260 5071 6q26 human S10-p 1434220100 VFVRFNSsHGFPVEV ubiquitin phosphorylation 23256036 1 1 0 S9, S10, S101 might be priming phosphorylation sites for S65 phosphorylarion +BECN1 beclin 1 Adaptor/scaffold; Autophagy; Membrane protein, peripheral Q14457 8678 17q21.31 human S96-p 472002 MSTESANsFTLIGEA molecular association, regulation carcinogenesis, inhibited; autophagy, induced; signaling pathway regulation DNAJB12(INDUCES); SLC7A11(INDUCES) 24685158; 30057310; 31220095 4 2 1 induces lipid peroxidation and ferroptosis; TM219-IGFBP3 signaling +Stim1 STIM1 Calcium-binding; Endoplasmic reticulum; Membrane protein, integral P70302 20866 7 E2-E3|7 54.71 cM mouse S608-p 3195758 PSVPPGGsPLLDSSH molecular association, regulation; protein conformation ORAI1(INDUCES); EB1(INDUCES) 20736304; 23687376 7 19 0 calcium mobilization and EB1-dependent STIM1 multimerization ; regulate store operated calcium entry (SOCE) +MACF1 ACF7 Actin-binding; Cytoskeletal; Motility/polarity/chemotaxis Q9UPN3 23499 1p34.3 human S7322-p 18507008 RAGSRAGsRASSRRG intracellular localization cell motility, induced; cytoskeletal reorganization 21295697 1 1 1 inhibits localization along microtubules, alters organization of microtubules, regulates skin wound repair, SC migration +STRAP STRAP Adaptor/scaffold; RNA splicing; UBIQUITIN LIGASE; Ubiquitin ligase Q9Y3F4 11171 12p12.3 human K156-ac 1876755702 ALWCSEDkQILSADD WD40 protein stabilization transcription, induced 32527012 1 0 0 upregulation and stabilization of p53 as well as its targets +Slc24a2 SLC24A2 Membrane protein, integral; Membrane protein, multi-pass; Transporter; Transporter, SLC family O54701 84550 5q32 rat T166-p 471069 VPSLTVItEKLGISD Na_Ca_ex activity, induced 17038313 1 0 0 Mutation to alanine of T476 and either T166 or S504 (or possibly both) eliminates PDBu-induced enhancement (PIE) on the Na(+)/Ca(2+)+K(+) exchanger. +SMARCA4 SMARCA4 Cell cycle regulation; EC 3.6.1.-; EC 3.6.4.-; Helicase; Nuclear receptor co-regulator; Transcription, coactivator/corepressor; Tumor suppressor P51532 6597 19p13.2 human S31-p 1261736700 PGAMLGPsPGPSPGS protein degradation; molecular association, regulation; ubiquitination FBXW7(INDUCES) 30177679 1 0 0 +CCAR1 CCAR1 Apoptosis; Nuclear receptor co-regulator; RNA splicing Q8IX12 55749 10q21.3 human S343-p 470613 RKRSRERsPRRERER protein stabilization; ubiquitination carcinogenesis, induced; cell growth, induced; apoptosis, inhibited; transcription, induced; signaling pathway regulation 35522902 1 1 0 inhibits ubiquitination of itself and induces ?-catenin stabilization, further inducing ?-catenin signalling +Oxtr OXTR GPCR, family 1; Membrane protein, integral; Membrane protein, multi-pass; Receptor, GPCR P70536 25342 4q41 rat S261-p 1876282800 AALARVSsVKLISKA 7tm_1 molecular association, regulation; phosphorylation signaling pathway regulation G-alpha(q)(INDUCES) 35104164 1 0 0 induces PKD1 and ERK1 phosphorylation, induces MAPK signaling +CENPU CENPU Cell cycle regulation Q71F23 79682 4q35.1 human S77-p 471407 TFDPPLHsTAIYADE protein degradation cell cycle regulation; cell growth, altered PLK1(INDUCES) 17081991 1 1 0 p-T78 peptides precipitated with Pl1K. Kinase activity of Plk1 is necessary for the in vivo interaction. The S77- T78 dependent interaction is sufficient to target Plk1 to the kinetochores. P-T78 dependent PBIP1 function is required for chromosome segregation, and is important for activation of spindle assembly checkpoint. +PTEN PTEN Carbohydrate Metabolism - inositol phosphate; EC 3.1.3.16; EC 3.1.3.48; EC 3.1.3.67; Motility/polarity/chemotaxis; Nuclear receptor co-regulator; PHOSPHATASE; Phosphatase, lipid; Tumor suppressor P60484 5728 10q23.31 human Y240-p 448316 RREDKFMyFEFPQPL PTEN_C2 enzymatic activity, induced cell growth, altered 11948419 3 1 0 +Tom1l1 Srcasm Adaptor/scaffold Q923U0 71943 11 D|11 55.47 cM mouse Y457-p 451210 APTTEAVyEEIDGYH molecular association, regulation cell growth, altered Fyn(INDUCES) 11711534; 17046829 4 2 35 mutation of this site promotes hyperproliferative phenotype +ULK1 ULK1 Autophagy; EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, Other; Protein kinase, Ser/Thr (non-receptor) O75385 8408 12q24.33 human S409-gl 1880900306 PSPSPPCsSSPSPSG protein stabilization; molecular association, regulation; phosphorylation autophagy, induced STX17(INDUCES); HSC70(DISRUPTS) 35931119 1 1 0 inhibits phosphorylation at S423 +GCK GK Carbohydrate Metabolism - amino sugar and nucleotide sugar; Carbohydrate Metabolism - galactose; Carbohydrate Metabolism - glycolysis and gluconeogenesis; Carbohydrate Metabolism - starch and sucrose; EC 2.7.1.2; Kinase, other; Mitochondrial P35557 2645 7p13 human K169-sm 27581516 GILLNWTkGFKASGA Hexokinase_1 protein stabilization; enzymatic activity, induced 23297408 1 1 0 +DDX1 DDX1 EC 3.6.4.13; Helicase; RNA-binding Q92499 1653 2p24.3 human S671-p 36406800 EHLNCTIsQVEPDIK molecular association, regulation RNA(INDUCES) 25176654 1 0 0 induces binding and maturatiuon of pri-miRNAs +PTK2B Pyk2 EC 2.7.10.2; KINASE; Kinase, protein; Nuclear receptor co-regulator; Protein kinase, TK; Protein kinase, tyrosine (non-receptor) Q14289 2185 8p21.2 human Y906-p 3091409 CQLPPEGyVVVVKNV Focal_AT molecular association, regulation SHP-2(INDUCES) 10880513 1 0 0 +PBXIP1 PBXIP1 Cytoskeletal Q96AQ6 57326 1q21.3 human S147-p 471206 REEGRCSsSDDDTDV protein degradation; ubiquitination transcription, induced; signaling pathway regulation 24488098 1 14 8 necessary for estrogen-mediated GREB1 expression; ERK1/2 and Akt1/3 signaling pathways +Bckdha BCKDH E1-alpha Amino Acid Metabolism - valine, leucine and isoleucine degradation; EC 1.2.4.4; Lyase; Mitochondrial; Oxidoreductase P50136 12039 7|7 A3 mouse S334-p 449636 TYRIGHHsTSDDSSA E1_dh activity, inhibited 24895126 10 60 24 decrease in plasma BCAA concentration +Wasf2 WAVE2 Actin-binding; Motility/polarity/chemotaxis Q8BH43 242687 4 D2.3|4 66.22 cM mouse S137-p 4258800 PPPLNNLsPYRDDGK cell motility, induced 22617848 2 0 0 regulate multipolar-bipolar neuron transition and growth cone activities +NUMA1 NuMA-1 Cell cycle regulation; Motility/polarity/chemotaxis Q14980 4926 11q13.4 human T1812-p 477991 RSARRRTtQIINITM cell growth, induced; apoptosis, inhibited 23097092 1 6 107 cell proliferation increased +OSTF1 OSTF1 Adaptor/scaffold; Motility/polarity/chemotaxis Q92882 26578 9q21.13 human S202-p 456078 TDAVRTLsNAEDYLD molecular association, regulation; intracellular localization carcinogenesis, induced; cell motility, induced MYO1E(DISRUPTS) 21501342; 27502487 2 27 12 +Exoc8 EXOC8 Vesicle O54924 245709 19q12 rat S505-p 25291117 QVFDSKEsLSTAAEC Exo84_C molecular association, regulation exocytosis, inhibited Sec5(DISRUPTS); EXOC8(DISRUPTS) 28325821 1 1 1 +GJA1 GJA1 Channel, misc.; Membrane protein, integral; Membrane protein, multi-pass; Motility/polarity/chemotaxis P17302 2697 6q22.31 human S328-p 449993 GQAGSTIsNSHAQPF Connexin43 protein conformation 23828237 10 13 0 +MEN1 MEN1 iso1 Transcription, coactivator/corepressor O00255-1 4221 11q13.1 human S548-p 470121 QVPAPTAsPPPEGPV Menin molecular association, regulation POLR2A(DISRUPTS) 21264250 2 16 1 +CCDC50 CCDC50 Inhibitor Q8IVM0 152137 3q28 human Y146-p 454596 AYADSYYyEDGGMKP molecular association, regulation EGFR(INDUCES) 16803894 1 5 18 inhibits the down-regulation of EGFR +ASIC2 ASIC2 Apoptosis; Channel, cation; Membrane protein, integral; Membrane protein, multi-pass; Transporter; Transporter, ion channel Q16515 40 17q11.2-q12 human T39-p 455992 IFVYGPLtIRRVLWA ASC; TM activity, induced 12399460 1 0 0 +Casp9 CASP9 Apoptosis; EC 3.4.22.62; Protease Q8C3Q9 12371 4|4 E1 mouse S348-p 484609 SQGRTLDsDSEPDAV Peptidase_C14 protein processing apoptosis, inhibited 18467326 1 6 0 inhibits protein cleavage by caspase 8 +MAD1L1 MAD1L1 Cell cycle regulation; Cytoskeletal Q9Y6D9 8379 7p22.3 human T708-p 5024703 PAFLSSLtLELFSRQ MAD intracellular localization 18922800 1 1 0 +ARHGEF2 ARHGEF2 iso2 GEF; GEF, Rac/Rho; Motility/polarity/chemotaxis Q92974-2 9181 1q22 human S885-p 451365 PVDPRRRsLPAGDAL molecular association, regulation; activity, inhibited; phosphorylation cytoskeletal reorganization; signaling pathway regulation 14-3-3 zeta(INDUCES) 22072711; 24352660 12 47 145 induces binding to microtubules, microtubule stabilization, inhibits MLC phosphorylation, modulates Rho signaling; represses RhoA-dependent stress fiber formation +Havcr1 TIM-1 Membrane protein, integral Q5QNS5 171283 11|11 B1.1 mouse Y299-p 20842101 SRAEDNIyIVEDRP_ signaling pathway regulation 21513984 2 0 7 regulates TIM-1 downstream signaling +Amph amphiphysin Vesicle Q7TQF7 218038 13 A2|13 6.89 cM mouse S293-p 465542 PAPVRPRsPSQTRKG molecular association, regulation endocytosis, altered endophilin A1(DISRUPTS) 23651931 4 1 2 +NUSAP1 NUSAP1 Cell cycle regulation; Nucleolus Q9BXS6 51203 15q15.1 human T338-p 3211263 GNSAAVItPFKLTTE NUSAP molecular association, regulation; intracellular localization cytoskeletal reorganization 22101338 1 13 4 inhibits NUSAP binding to microtubules in mitosis +CTNNB1 CTNNB1 Actin-binding; Cell adhesion; Motility/polarity/chemotaxis; Nuclear receptor co-regulator; Oncoprotein; Transcription factor P35222 1499 3p22.1 human K345-ac 459029 WTTSRVLkVLSVCSS activity, induced; molecular association, regulation transcription, induced TCF4(INDUCES); LEF-1(INDUCES); AR(DISRUPTS) 15060161; 26477307 2 0 0 +Cask CASK Adaptor/scaffold; EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, CAMK; Protein kinase, Ser/Thr (non-receptor) O70589 12361 X A1.1|X 8.43 cM mouse S395-p 1261102 DKINTKSsPQIRNPP L27 molecular association, regulation; intracellular localization liprin alpha 1(DISRUPTS) 18054859 1 3 0 promotes CASK recruitment to presynaptic membranes and interaction with presynaptic proteins (Veli, Mint1, neurexins, N-type voltage-gated calcium channels); ; promotes calcium influx into neurons; promotes synaptogenesis +DNMT3A DNMT3A Amino Acid Metabolism - cysteine and methionine; EC 2.1.1.37; METHYLTRANSFERASE; Methyltransferase; Methyltransferase, DNA Q9Y6K1 1788 2p23.3 human S255-p 4700048 QQPTDPAsPTVATTP molecular association, regulation; intracellular localization transcription, induced DNA(DISRUPTS) 25159139 2 13 0 blocks transcription of SOX9, collagen II and aggrecan +TBXA2R TXA2-R GPCR, family 1; Membrane protein, integral; Membrane protein, multi-pass; Receptor, GPCR P21731 6915 19p13.3 human S331-p 470029 STRPRSLsLQPQLTQ activity, induced; receptor desensitization, induced; molecular association, regulation; receptor desensitization, altered signaling pathway regulation 12370102; 17466390; 24490858 3 16 4 +MPZ myelin P0 Adaptor/scaffold; Membrane protein, integral P25189 4359 1q23.3 human S233-p 458933 SRSTKAVsEKKAKGL Myelin-PO_C intracellular localization 16493674 4 1 0 +Bcar1 P130Cas Adaptor/scaffold; Motility/polarity/chemotaxis Q61140 12927 8|8 E1 mouse Y169-p 448722 PSPATDLyQVPPGPG cell motility, altered 20430882 13 1 0 SH3 and CCH domains are required for P130Cas tyrosine phosphorylation and promoting cell migration. +RAF1 RAF1 EC 2.7.11.1; KINASE; Kinase, protein; Oncoprotein; Protein kinase, Ser/Thr (non-receptor); Protein kinase, TKL P04049 5894 3p25.2 human S233-p 448651 VSSQHRYsTPHAFTF molecular association, regulation 14-3-3 beta(INDUCES); HRas(DISRUPTS) 12801936 3 1 2 +RXRA RXRA DNA-binding; Motility/polarity/chemotaxis; Nuclear receptor P19793 6256 9q34.2 human Y249-p 456812 VEPKTETyVEANMGL activity, inhibited transcription, inhibited; transcription, altered 10938283; 20432439 2 0 0 +TNK2 Ack EC 2.7.10.2; EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, TK; Protein kinase, tyrosine (non-receptor) Q07912 10188 3q29 human Y859-p 448883 KKVSSTHyYLLPERP protein conformation; enzymatic activity, induced 36178070 3 34 584 +Erg ERG DNA-binding; Oncoprotein; Transcription factor P81270 13876 16 C4|16 56.04 cM mouse S222-p 9429097 VDKALQNsPRLMHAR intracellular localization 34314419 3 13 2 +Nos1 nNOS Amino Acid Metabolism - arginine and proline; EC 1.14.13.39; Oxidoreductase P29476 24598 12q16 rat K1321-ac 2459110 REPDRPKkYVQDVLQ NAD_binding_1 activity, induced 18415985 1 0 0 +CD28 CD28 Cell surface; Membrane protein, integral P10747 940 2q33.2 human Y191-p 450282 SRLLHSDyMNMTPRR molecular association, regulation transcription, inhibited CSK(INDUCES); GADS(INDUCES) 10820259; 20368329; 31292214 10 7 317 +LCP2 SLP76 Adaptor/scaffold Q13094 3937 5q35.1 human Y173-p 456736 FPNSNSMyIDRPPSG protein conformation; phosphorylation exocytosis, induced; transcription, induced; signaling pathway regulation 21725281; 31196981; 33931484 4 4 141 induces TCR signaling +STIM1 STIM1 Calcium-binding; Endoplasmic reticulum; Membrane protein, integral Q13586 6786 11p15.4 human S486-p 11485308 DMDEEIVsPLSMQSP activity, inhibited 19881501 2 0 0 involved in suppression of store-operated calcium entry during mitosis +TRAP1 HSP75 Chaperone; Heat shock protein Q12931 10131 16p13.3 human S568-p 27450720 EEKFEDRsPAAECLS HSP90 carcinogenesis, induced; cell growth, induced 28099845 1 4 0 +HSPB1 HSP27 Chaperone; Heat shock protein; Motility/polarity/chemotaxis; SUMO LIGASE; SUMO ligase Q00649 chicken S15-p 448401 FTFLTSPsWEPFRDW protein conformation 12429504 52 78 30 Mutations mimicking phosphorylation of sites single (S15D) and in combination form high and low molecular oligomers and affect chaperone activity in vitro. +CHFR CHFR EC 6.3.2.-; EC 6.3.2.19; Ligase; UBIQUITIN LIGASE; Ubiquitin conjugating system; Ubiquitin ligase Q96EP1 55743 12q24.33 human K384-ub 25090301 QSMDARNkITQDMLQ protein degradation cell cycle regulation 21768102 1 0 0 auto-ubiquitylation and CHFR degradation regulate the G2/M transition +Dnm1 DYN1 EC 3.6.5.5; Hydrolase; Microtubule-binding; Motility/polarity/chemotaxis; Motor; Vesicle P21575 140694 3p12 rat Y597-p 447606 NTEQRNVyKDYRQLE PH molecular association, regulation; receptor internalization, altered; activity, inhibited; protein conformation 12011079; 9880482 2 0 0 Y231/597F mutant Inhibits B2-AR internalization, and inhibited the isoproterenol mediated activation of ERK2.; Tyrosine phosphorylation promotes DYN1 self assembly. +EDC4 EDC4 RNA processing Q6P2E9 23644 16q22.1 human S583-p 4271998 PAPADFLsLSSETKP RNA stability, altered 30467221 1 5 15 increase formation of P bodies +GFI1 GFI1 C2H2-type zinc finger protein; Cell cycle regulation; Cell development/differentiation; Transcription factor Q99684 2672 1p22.1 human K8-m2 62504400 MPRSFLVkSKKAHSY molecular association, regulation; methylation carcinogenesis, induced; cell growth, induced; transcription, inhibited LSD1(INDUCES) 27480105 1 0 0 promotes H3K4 demethylation +MAX MAX iso2 DNA-binding; Transcription factor P61244-2 4149 14q23.3 human S2-p 449307 ______MsDNDDIEV activity, inhibited transcription, altered 8018564 5 35 0 phosphorylation-deficient mutant inhibits transcription more efficiently +PA2G4 Ebp1 Nuclear receptor co-regulator; Nucleolus; Transcription, coactivator/corepressor Q9UQ80 5036 12q13.2 human S363-p 981405 ALLQSSAsRKTQKKK molecular association, regulation; intracellular localization transcription, inhibited; cell growth, altered SIN3A(INDUCES); HDAC2(INDUCES) 17786317 1 4 0 nuclear localization +Adora3 ADORA3 GPCR, family 1; Membrane protein, integral; Membrane protein, multi-pass; Receptor, GPCR P28647 25370 2q34 rat T319-p 450330 DSNLEQTtE______ receptor desensitization, altered 10692494 1 0 0 +BCL10 Bcl-10 Apoptosis; Transcription, coactivator/corepressor; Tumor suppressor O95999 8915 1p22.3 human S136-p 15402376 ATNNLSRsNSDESNF activity, induced 21199863 1 1 1 +Pag1 PAG Adaptor/scaffold; Membrane protein, integral Q9JM80 64019 2q23 rat Y409-p 448996 LVPKENDyESIGDLQ PAG intracellular localization cytoskeletal reorganization; cell growth, altered 18498747; 19124084 3 38 657 +BAP1 BAP1 DEUBIQUITINASE; EC 3.4.19.12; Protease; Tumor suppressor; Ubiquitin conjugating system; Ubiquitin-specific protease Q92560 8314 3p21.1 human S571-p 31012815 LAEDGVLsPLALTEG intracellular localization DNA repair, induced 24347639 1 1 0 +CCNA2 CCNA2 Cell cycle regulation; Nuclear receptor co-regulator P20248 890 4q27 human K54-ac 7761214 RAALAVLkSGNPRGL Cyclin_N2 protein degradation; molecular association, regulation cell cycle regulation CDK2(DISRUPTS) 19483727; 23760262 2 1 0 +DYRK2 DYRK2 EC 2.7.12.1; KINASE; Kinase, protein; Protein kinase, CMGC; Protein kinase, dual-specificity (non-receptor) Q92630 8445 12q15 human T106-p 11489910 NKRTVLTtQPNGLTT protein stabilization; molecular association, regulation; intracellular localization MDM2(DISRUPTS) 19965871 2 1 0 +IKBKG IKKG Adaptor/scaffold; Protein kinase, regulatory subunit Q9Y6K9 8517 Xq28 human K277-sm 2255104 AEEALVAkQEVIDKL CC2-LZ molecular association, regulation; intracellular localization apoptosis, inhibited; transcription, induced ATM(INDUCES) 14651848; 16906147; 18583959; 20065354 6 0 0 +Cend1 CEND1 Membrane protein, integral Q9JKC6 57754 7|7 F5 mouse S10-p 10285828 SRGKSASsPKPDTKV CEND1 protein degradation; ubiquitination 35732922 1 8 0 +CHKA CHKA EC 2.7.1.32; EC 2.7.1.82; Kinase, other; Lipid Metabolism - glycerophospholipid P35790 1119 11q13.2 human Y333-p 21041605 LMLIDFEySSYNYRG Choline_kinase molecular association, regulation; enzymatic activity, induced carcinogenesis, induced; cell growth, induced; transcription, induced; translation, induced EGFR(INDUCES) 21822308 1 1 0 increases CHKA protein levels +APP APP Apoptosis; Cell surface; Membrane protein, integral; Receptor, misc.; Transcription factor P05067 351 21q21.3 human K763-sm 1881446403 GYENPTYkFFEQMQN protein stabilization; molecular association, regulation; intracellular localization transcription, induced Fe65(INDUCES) 32950104 1 0 0 increases CREB binding to the NEP promoter; NEP and TTR expression; nuclear translocation; reduces amyloid plaque deposits; decreases AB oligomerization, and amyloid plaque deposits +Ube3c UBE3C EC 6.3.2.-; EC 6.3.2.19; Ligase; UBIQUITIN LIGASE; Ubiquitin conjugating system; Ubiquitin ligase Q80U95 100763 5|5 B1 mouse S741-p 1884003508 EDAYDKLsPENEPDL protein stabilization; ubiquitination; enzymatic activity, inhibited 35914132 1 0 0 inhibits ubiquitination and degradation of PR +Ptprc CD45 EC 3.1.3.48; Membrane protein, integral; Motility/polarity/chemotaxis; PHOSPHATASE; Receptor protein phosphatase, tyrosine P06800 19264 1 E4|1 60.73 cM mouse S990-p 449972 SKESEPEsDESSDDD Y_phosphatase enzymatic activity, induced 10066810 1 4 0 +NTRK1 TrkA EC 2.7.10.1; KINASE; Kinase, protein; Membrane protein, integral; Oncoprotein; Protein kinase, TK; Protein kinase, tyrosine (receptor) P04629 4914 1q23.1 human Y496-p 447762 HIIENPQyFSDACVH molecular association, regulation; receptor internalization, altered; enzymatic activity, induced cell differentiation, altered; apoptosis, induced; cell growth, altered FRS2(INDUCES); SHC1(INDUCES); SHC1 iso2(INDUCES) 10617652; 10629055; 12237775; 15601748; 15955426; 8155326 23 0 2 regulate NGF induced neurite outgrowth and ERK activity +RIPK3 RIPK3 EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, Ser/Thr (non-receptor); Protein kinase, TKL Q9Y572 11035 14q12 human T165-p 1877504600 LADFGLStFQGGSQS Pkinase enzymatic activity, inhibited; phosphorylation 35739084 1 0 0 inhibits MLKL phosphorylation and necroptosis +SYK Syk EC 2.7.10.2; KINASE; Kinase, protein; Protein kinase, TK; Protein kinase, tyrosine (non-receptor) P43405 6850 9q22.2 human Y348-p 447659 LPMDTEVyESPYADP molecular association, regulation; enzymatic activity, induced ITGAM(INDUCES); PLCG1(INDUCES) 18818202; 30923129; 8657103 15 12 112 +TYMS TYMS Cofactor and Vitamin Metabolism - one carbon pool by folate; DNA repair, damage; EC 2.1.1.45; METHYLTRANSFERASE; Methyltransferase; Mitochondrial; Nucleotide Metabolism - pyrimidine P04818 7298 18p11.32 human S124-p 13209303 FLDSLGFsTREEGDL Thymidylat_synt molecular association, regulation; enzymatic activity, inhibited; protein conformation 20430630 2 1 0 incorrect binding alignment of substrate dUMP and THF to phosphorylated TYMS +MDM4 MDM4 EC 6.3.2.-; Ligase; UBIQUITIN LIGASE; Ubiquitin conjugating system; Ubiquitin ligase O15151 4194 1q32.1 human Y99-p 6039500 VKDPSPLyDMLRKNL protein stabilization; molecular association, regulation; protein conformation; phosphorylation 53BP1(DISRUPTS); p53(DISRUPTS) 19075013; 26148237; 29348869 3 1 0 +Plin1 perilipin 1 Lipid-binding Q8CGN5 103968 7|7 D2 mouse S517-p 471365 YSQLRKKs_______ activity, induced; molecular association, regulation ABHD5(DISRUPTS) 17114792; 19850935 11 0 1 stimulates perilipin-mediated lipolysis in adipocytes; induces dissociation of ABHD5 from perilipin and its association with Atgl +MAP1LC3A LC3A Autophagy; Microtubule-binding; Ubiquitin-like modifier; Vesicle Q9H492 84557 20q11.22 human S12-p 15116600 RPFKQRRsFADRCKE intracellular localization autophagy, altered 20713600; 27390127 2 1 0 +KAT5 Tip60 iso3 ACETYLTRANSFERASE; Acetyltransferase; EC 2.3.1.48; Nuclear receptor co-regulator; Nucleolus Q92993-3 10524 11q13.1 human S119-gl 1881440800 TKNGLPGsRPGSPER protein stabilization transcription, induced 34650217 1 0 0 accelerates EMT, HCC metastasis; inhibition of ubiquitylation; activation of TWIST1 by O-GlcNAcylation of TIP60 +IDH1 IDH1 Carbohydrate Metabolism - citrate (TCA) cycle; EC 1.1.1.42; Other Amino Acids Metabolism - glutathione; Oxidoreductase O75874 3417 2q34 human Y391-p 462261 PNVQRSDyLNTFEFM Iso_dh molecular association, regulation Other(INDUCES) 30862724 1 6 32 cofactor NADP+ binding to IDH1 +SRF SRF Motility/polarity/chemotaxis; Transcription factor P11831 6722 6p21.1 human S224-p 468829 TCLNSPDsPPRSDPT molecular association, regulation; acetylation; methylation transcription, induced MKL1(INDUCES) 34381779 1 45 2 regulates histone acetylation and methylation +ESRRA ERR1 DNA-binding; Nuclear receptor; Transcription regulation P11474 2101 11q13.1 human K68-ub 1877015602 PGEQGGGkLVLSSLP protein degradation cell differentiation, inhibited 31907393 1 0 0 +CACNA1C CACNA1C Channel, calcium; Membrane protein, integral; Membrane protein, multi-pass BAA34185.2 guinea pig T1603-p 7437803 RTALRIKtEGNLEQA Ca_chan_IQ activity, induced Calmodulin(INDUCES) 19340532 2 0 0 +GCSAM GCET2 Unknown function Q8N6F7 257144 3q13.2 human Y107-p 454098 GNSAEEYyENVPCKA HGAL activity, induced; molecular association, regulation signaling pathway regulation GRB2(INDUCES); GRB2(NOT_REPORTED) 17489982; 31362927 2 4 52 regulates B cell receptor signaling +Myb Myb DNA-binding; Oncoprotein; Transcription factor P06876 17863 10 A3|10 9.75 cM mouse K438-ac 459082 PCRDQTVkTQKENSI Cmyb_C molecular association, regulation transcription, induced CBP(INDUCES) 11073948 1 0 0 +BCL3 Bcl-3 Apoptosis; Nuclear receptor co-regulator; Oncoprotein; Transcription regulation P20749 602 19q13.32 human S454-p 31867760 PSPAPGGs_______ cell motility, induced; transcription, induced NFkB-p100(INDUCES) 28689659 1 2 0 +PRPF3 PRPF3 RNA processing; RNA splicing; Spliceosome O43395 9129 1q21.2 human T494-p 999610 TEAVQDPtKVEAHVR PRP3 molecular association, regulation; protein conformation cell growth, altered PRPF6(INDUCES); PRPF4(INDUCES) RNA(INDUCES) 17932117 1 0 0 T494M mutation weakens self association and association with PRPF4, PRP6, and U4 and U6 snRNAs. +FBXO43 FBX43 Unknown function Q4G163 286151 8q22.2 human T234-p 13419500 FSQQKTStIDDSKDD protein degradation; molecular association, regulation PLK1(INDUCES) 16407128 2 0 0 +MID1 MID1 Cytoskeletal; EC 6.3.2.-; EC 6.3.2.19; Ligase; UBIQUITIN LIGASE; Ubiquitin conjugating system; Ubiquitin ligase O15344 4281 Xp22.2 human S96-p 3245015 ASVSGPNsPSETRRE intracellular localization cell motility, inhibited 18949047 1 25 0 neural crest migration +HSF1 HSF1 DNA-binding; Transcription factor Q00613 3297 8q24.3 human S121-p 455480 NIKRKVTsVSTLKSE molecular association, regulation; intracellular localization; activity, inhibited HSP90A(INDUCES); ZAP(DISRUPTS) 16278218; 25425574; 29661921 5 7 1 +Cavin1 PTRF Transcription initiation complex O54724 19285 11 D|11 63.95 cM mouse Y158-p 458334 RNFKVMIyQDEVKLP PTRF_SDPR molecular association, regulation; intracellular localization IL33(DISRUPTS) 29977243 1 24 347 dephosphorylation of Y158 sequestered IL-33 in the nucleus limiting release +Gphn gephyrin Adaptor/scaffold; EC 2.10.1.1; EC 2.7.7.75 Q8BUV3 268566 12|12 C3 mouse S188-p 478376 DELEDLPsPPPPLSP molecular association, regulation PIN1(INDUCES) 17347650 3 43 1 +F2R PAR1 Cell development/differentiation; GPCR, family 1; Membrane protein, integral; Membrane protein, multi-pass; Receptor, GPCR P25116 2149 5q13.3 human Y383-p 451198 SECQRYVySILCCKE protein degradation; receptor internalization, altered 15023990 1 0 5 +Dll1 DLL1 Cell development/differentiation; Membrane protein, integral; Motility/polarity/chemotaxis Q61483 13388 17 A2|17 8.95 cM mouse S693-p 31012806 PDRKRPEsVYSTSKD transcription, induced 24449764 1 1 0 mutant shows increased stability +EXO1 EXO1 EC 3.1.-.-; Hydrolase Q9UQ84 9156 1q43 human T621-p 1240808 GLGDFSRtPSPSPST protein degradation 18048416 1 2 0 +NCOA2 SRC-2 Motility/polarity/chemotaxis; Nuclear receptor co-regulator; Transcription, coactivator/corepressor Q15596 10499 8q13.3 human K788-sm 2793921 LIAMKTEkEEMSFEP DUF4927 molecular association, regulation; intracellular localization transcription, induced AR(INDUCES) 12060666 1 0 0 AR-dependent transcription +Pxn PXN Adaptor/scaffold; Cell adhesion; Cytoskeletal; Motility/polarity/chemotaxis Q8VI36 19303 5 F|5 56.1 cM mouse Y88-p 448909 PPSPLPVySSSAKNS Paxillin carcinogenesis, induced; cell growth, altered 20133777 6 48 1343 +RG1 PPP1R3A Membrane protein, integral; Protein phosphatase, regulatory subunit Q00756 100009140 rabbit S48-p 449320 PQPSRRGsESSEEVY enzymatic activity, induced 8175660 5 5 0 +FOSL1 FRA1 DNA-binding; Transcription factor P15407 8061 11q13.1 human T223-p 1270901 HTPTLMTtPSLTPFT protein stabilization 17371847; 22286759 2 0 0 +IRF5 IRF5 DNA-binding; Transcription factor Q13568 3663 7q32.1 human S440-p 455995 ELSWSADsIRLQISN activity, induced; molecular association, regulation transcription, induced CBP(INDUCES) 12138184; 18836453 2 0 0 +Cyth2 cytohesin 2 GEF; GEF, ARF P63034 19158 7|7 B3 mouse Y381-p 4003314 AVSVDPFyEMLAARK activity, induced; molecular association, regulation ARF6(INDUCES); SH2-B-beta(INDUCES); GGA3(INDUCES) 35077201 1 0 33 +RGD1359108 C9orf72 Q66HC3 313155 rat S9-p 27720969 STICPPPsPAVAKTE protein degradation; ubiquitination autophagy, inhibited 37353944 1 6 0 +NAMPT PBEF Cell cycle regulation; Cofactor and Vitamin Metabolism - nicotinate and nicotinamide; Cytokine; EC 2.4.2.12; Transferase P43490 10135 7q22.3 human S314-p 40512819 PLIIRPDsGNPLDTV NAPRTase molecular association, regulation; enzymatic activity, induced DNA repair, induced; cell growth, induced Other(INDUCES) 36196536 1 2 0 induces binding to phosphoribosyl pyrophosphate +NR4A1 Nur77 Apoptosis; DNA-binding; Nuclear receptor P22736 3164 12q13.13 human Y60-p 41583608 FSTFMDGyTGEFDTF cell motility, induced; cell growth, induced; cytoskeletal reorganization 26155943 1 0 0 required for increase in cell growth, cell motility, monolayer permeability, and formation of actin stress fibers. +Cry1 CRY1 DNA-binding; Lyase; Transcription, coactivator/corepressor P97784 12952 10 C1|10 41.63 cM mouse S71-p 11952908 ANLRKLNsRLFVIRG DNA_photolyase protein degradation; molecular association, regulation PER2(DISRUPTS); FBXL3(INDUCES) 19833968; 31258021 3 0 0 contributes to changes in voluntary activity levels +Aqp2 AQP2 Channel, misc.; Membrane protein, integral; Membrane protein, multi-pass; Transporter; Transporter, aquaporin family P34080 25386 7q36 rat S261-p 464644 RQSVELHsPQSLPRG molecular association, regulation; ubiquitination; intracellular localization; activity, inhibited exocytosis, induced; endocytosis, inhibited GRP78(DISRUPTS); GDI2(DISRUPTS); HSP70(DISRUPTS); RAN(DISRUPTS); ANXA2(DISRUPTS); HSC70(DISRUPTS); PPP1CA(DISRUPTS) 19209902; 21148409; 21525134; 26147297; 27488997; 28668390; 32113684 38 9 0 +Kif23 KIF23 Microtubule-binding; Motility/polarity/chemotaxis; Motor E9Q5G3 71819 9|9 B mouse S905-p 459841 GSRKRRSsTLAPAQP intracellular localization cell cycle regulation; cytoskeletal reorganization 15199097 1 12 273 regulates cytokinesis +SQSTM1 SQSTM1 Autophagy; Nuclear receptor co-regulator; Ubiquitin conjugating system Q13501 8878 5q35.3 human T138-p 900975704 CNGPVVGtRYKCSVC ZZ apoptosis, induced 29519959 1 1 0 +GYS1 GYS1 Carbohydrate Metabolism - starch and sucrose; EC 2.4.1.11; Transferase P13807 2997 19q13.33 human S653-p 448240 PSLSRHSsPHQSEDE Glycogen_syn activity, inhibited 22510711 13 24 4 +TH TH Amino Acid Metabolism - tyrosine; EC 1.14.16.2; Endoplasmic reticulum; Mitochondrial; Oxidoreductase; Vesicle P07101 7054 11p15.5 human S19-p 448542 KGFRRAVsELDAKQA TOH_N molecular association, regulation; protein conformation; enzymatic activity, induced 14-3-3 zeta(INDUCES); 14-3-3 gamma(INDUCES) 16626642; 24055376; 34031189 46 9 4 +NCAPH2 NCAPH2 Cell cycle regulation; Endoplasmic reticulum; Membrane protein, integral Q6IBW4 29781 22q13.33 human S492-p 459636 FVQETELsQRIRDWE CNDH2_C intracellular localization cell cycle regulation 24934155 2 15 36 chromosome condensation +MITF MITF iso9 DNA-binding; Oncoprotein; Transcription factor O75030-9 4286 3p13 human S401-p 11125701 SSVSPGAsKTSSRRS DUF3371 protein degradation 25605940 1 1 1 +PRKCE PKCE EC 2.7.11.13; KINASE; Kinase, protein; Protein kinase, AGC; Protein kinase, Ser/Thr (non-receptor) Q02156 5581 2p21 human K534-sm 1870790710 GVIYRDLkLDNILLD Pkinase sumoylation; enzymatic activity, induced 33027667 1 0 0 PKCE phosphorylation is required for it's sumoylation; K534 sumoylation plays a critical role in the development of in?ammatory thermal hyperalgesia +Nrip1 RIP140 Nuclear receptor co-regulator; Transcription, coactivator/corepressor Q8CBD1 268903 16|16 C3.1 mouse K447-ac 458975 VPIDLSCkHRIEKPE NRIP1_repr_2 molecular association, regulation CTBP1(DISRUPTS) 11509661 1 0 0 loss of transcription repression +DTD1 DTD1 DNA replication; EC 3.1.-.-; Hydrolase Q8TEA8 92675 20p11.23 human S181-p 36396300 RAKGPSEsSKERNTP molecular association, regulation cell cycle regulation; cell growth, induced MCM7(INDUCES); MCM3(DISRUPTS) 25258324 1 0 0 decreases DTD1 incorporation into HMW, supports DNA replication initiation +H1-4 H1E DNA-binding P10412 3008 6p22.2 human S27-p 476058 VKKKARKsAGAAKRK molecular association, regulation CBX1(DISRUPTS); CBX3(DISRUPTS); HP1 alpha(DISRUPTS) 16127177 2 2 7 disrupts K26-methyl induced binding to HP1 +FYN Fyn EC 2.7.10.2; KINASE; Kinase, protein; Oncoprotein; Protein kinase, TK; Protein kinase, tyrosine (non-receptor) P06241 2534 6q21 human Y213-p 451536 RKLDNGGyYITTRAQ SH2 molecular association, regulation; intracellular localization; enzymatic activity, induced apoptosis, inhibited Exportin-1(INDUCES) 21097520; 27001024 2 39 1783 +Gucy1a1 GUCY1A1 EC 4.6.1.2; Guanylyl cyclase; Lyase; Nucleotide Metabolism - purine; Receptor, misc. P19686 497757 2q34 rat S107-p 450954 KIKENRNsSEKEDLE enzymatic activity, induced 14630997 1 1 0 +Prkce PKCE EC 2.7.11.13; KINASE; Kinase, protein; Protein kinase, AGC; Protein kinase, Ser/Thr (non-receptor) P16054 18754 17|17 E4 mouse T566-p 448787 MNGVTTTtFCGTPDY Pkinase enzymatic activity, induced 12640464 6 2 0 +ACE2 ACE2 EC 3.4.17.23; Membrane protein, integral; Protease Q9BYF1 59272 Xp22.2 human K112-ub 1880091002 SSVLSEDkSKRLNTI Peptidase_M2 protein degradation 35894122 1 1 0 +HBP1 HBP1 DNA-binding; Transcription factor O60381 26959 7q22.3 human S372-p 63253100 SAVYVLSsMARQRRA activity, induced; protein stabilization cell growth, inhibited; apoptosis, induced; transcription, altered DNA(INDUCES) 28348080 1 1 0 HBP1-mediated DNMT1 repression and p16 activation +GEM GEM G protein; G protein, monomeric; G protein, monomeric, RGK P55040 2669 8q22.1 human S261-p 450647 AYQKRKEsMPRKARR molecular association, regulation; intracellular localization cytoskeletal reorganization KPNA5(DISRUPTS) 14701738; 17605761 2 0 0 interaction abolished in triple phosphomimetic mutant S261/287/289D; Cell flattening and neurite extension; interaction increased in S261 alanine mutant +CD300LF IREM-1 Immunoglobulin superfamily; Membrane protein, integral; Receptor, misc. Q8TDQ1 146722 17q25.1 human Y249-p 474546 LPKEDISyASLTLGA SIT activity, induced; molecular association, regulation SHP-1(INDUCES) 17202342 2 0 0 mutation of site to Phe decreased the inhibitory activity of IREM-1 +SLC12A2 NKCC1 Membrane protein, integral; Membrane protein, multi-pass; Transporter; Transporter, SLC family P55011 6558 5q23.3 human S77-p 3192079 RPLGPTPsQSRFQVD activity, inhibited 24702155 2 16 7 Co-transporter activity of NKCC1 is reduced. +RPS6KA1 p90RSK EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, AGC; Protein kinase, Ser/Thr (non-receptor); Translation P18652 386579 chicken S398-p 447990 HQLFRGFsFVATGLM Pkinase_C molecular association, regulation; intracellular localization; enzymatic activity, induced PDK1(INDUCES) 11585927 66 48 64 +Ntrk2 TrkB EC 2.7.10.1; KINASE; Kinase, protein; Membrane protein, integral; Protein kinase, TK; Protein kinase, tyrosine (receptor) Q63604 25054 17p14 rat Y816-p 451754 LAKASPVyLDILG__ molecular association, regulation translation, altered; signaling pathway regulation PLCG1(INDUCES); CBL(INDUCES) 10533983; 22563458 20 0 0 c-fos protein synthesis induced by BDNF; activation of PLC-gamma1 and MAPK/PI3K signal transduction pathways +Dlc1 DLC1 GAP; GAP, Rac/Rho; Tumor suppressor Q9R0Z9 50768 8 A4|8 23.05 cM mouse S550-p 467752 DIPERRDsGVGASLT activity, induced; molecular association, regulation; activity, inhibited; phosphorylation carcinogenesis, inhibited; cell growth, inhibited; cytoskeletal reorganization; cell motility, inhibited tensin 2(INDUCES); DLC1(INDUCES) 23511482 1 17 8 Increased GAP activity further inhibiting RhoA activity; induces phosphorylation of S432 +CHRM2 mAChR M2 GPCR, family 1; Membrane protein, integral; Membrane protein, multi-pass; Receptor, GPCR P08172 1129 7q33 human T307-p 459106 EITQDENtVSTSLGH 7tm_1 receptor desensitization, altered; receptor internalization, altered 9162044 3 0 0 Mutation of 4 S/T to A eliminates receptor desensitization in response to carbachol treatment (as measured by isoproterenol-stimulated cAMP production after pretreatment with carbachol).; Mutation of S286 T287 S288 S290 to A caused a faster rate and a greater extent of receptor internalization after agonist stimulation (transients only, not observed in stables). Mutation of all 8 sites prevented internalization (in both transients and stables). +Ep300 p300 ACETYLTRANSFERASE; Acetyltransferase; EC 2.3.1.48; Motility/polarity/chemotaxis; Nuclear receptor co-regulator; Transcription, coactivator/corepressor B2RWS6 328572 15|15 E1 mouse S89-p 447592 SELLRSGsSPNLNMG molecular association, regulation transcription, altered; signaling pathway regulation; transcription, inhibited 14-3-3 epsilon(INDUCES); CTNNB1(INDUCES) 18849969; 33799418 14 2 0 Wnt/CBP/catenin signaling +MAPK7 ERK5 EC 2.7.11.24; KINASE; Kinase, protein; Protein kinase, CMGC; Protein kinase, Ser/Thr (non-receptor) Q13164 5598 17p11.2 human T733-p 455520 LPPVFSGtPKGSGAG intracellular localization; enzymatic activity, inhibited; phosphorylation; enzymatic activity, induced cell growth, induced; apoptosis, inhibited; transcription, induced; transcription, altered 20667468; 25689862; 29483645; 30132833; 31201162 7 13 1 MYCN protein; in DIPG cells +Cacnb2 CACNB2 iso2 Channel, calcium Q8VGC3-2 116600 17q12.3 rat T498-p 470081 RGLSRQEtFDSETQE molecular association, regulation; phosphorylation CAMK2A(INDUCES) 19840220 5 8 30 enhances phosphorylation of CACNB2 +MACF1 ACF7 Actin-binding; Cytoskeletal; Motility/polarity/chemotaxis Q9UPN3 23499 1p34.3 human S7226-p 18507015 GRRSKPSsRAASPTR intracellular localization cell motility, induced; cytoskeletal reorganization 21295697 1 2 0 inhibits localization along microtubules, alters organization of microtubules, regulates skin wound repair, SC migration +PINX1 PINX1 Inhibitor; Nucleolus; Tumor suppressor Q96BK5 54984 8p23.1 human S110-p 14823406 SDKKEKKsFSLEEKS protein degradation; ubiquitination 20573420 1 2 0 +SH2B1 SH2-B-beta Adaptor/scaffold Q9NRF2 25970 16p11.2 human S165-p 21336501 VGRSVRGsVRGILQW intracellular localization cell motility, induced; cell adhesion, altered 21878491 2 0 0 regulates focal adhesion size and number +orf9b Accessory protein 9b P0DTD2 SARSCoV2 K40-ub 1883454305 DQNNVGPkVYPIILR protein degradation; ubiquitination 35638730 1 0 0 reduces ORF9b-mediated IFN and NF-kB inhibition +AKT1 Akt1 EC 2.7.11.1; KINASE; Kinase, protein; Oncoprotein; Protein kinase, AGC; Protein kinase, Ser/Thr (non-receptor) P31749 207 14q32.33 human T312-gl 25538003 TMKTFCGtPEYLAPE Pkinase enzymatic activity, inhibited; phosphorylation 22629392 1 1 0 suppresses Akt phosphorylation at T308 by disrupting its interaction with PDK1 +CDK2 CDK2 Cell cycle regulation; EC 2.7.11.22; KINASE; Kinase, protein; Protein kinase, CMGC; Protein kinase, Ser/Thr (non-receptor) P24941 1017 12q13.2 human K33-ac 1876403700 TGEVVALkKIRLDTE Pkinase enzymatic activity, inhibited cell cycle regulation; cell growth, inhibited 19773423 1 0 0 +NCOA2 SRC-2 Motility/polarity/chemotaxis; Nuclear receptor co-regulator; Transcription, coactivator/corepressor Q15596 10499 8q13.3 human S487-p 4728845 GQPTSMLsPRHRMSP NCOA_u2 carcinogenesis, induced; cell motility, induced; cell growth, induced; transcription, induced; signaling pathway regulation 22158970; 33593309 2 9 1 induces SRC-2/CARM1 signaling +Rasgrp2 RASGRP2 GEF; GEF, Ras Q9QUG9 19395 19|19 A mouse S116-p 468584 QEGNRRHsSLIDIES activity, induced; molecular association, regulation 14-3-3 beta(INDUCES) 26804993 3 10 31 +ELAVL1 HuR RNA-binding Q15717 1994 19p13.2 human Y200-p 460123 VALLSQLyHSPARRF intracellular localization RNA(DISRUPTS) 24106086 1 17 234 blocks localization in stress granules, labile mRNA +Ctnnb1 CTNNB1 Actin-binding; Cell adhesion; Motility/polarity/chemotaxis; Nuclear receptor co-regulator; Oncoprotein; Transcription factor Q02248 12387 9 F4|9 72.19 cM mouse S675-p 457120 QDYKKRLsVELTSSL protein stabilization; intracellular localization carcinogenesis, induced; transcription, induced; signaling pathway regulation 22966074; 26884171; 30897078; 32102932; 33815677; 33824474; 36068223 40 55 17 induces EMT +PKM PKM Carbohydrate Metabolism - glycolysis and gluconeogenesis; Carbohydrate Metabolism - pyruvate; EC 2.7.1.40; KINASE; Kinase, other; Mitochondrial; Nucleotide Metabolism - purine P14618 5315 15q23 human K305-ac 474712 GIEIPAEkVFLAQKM PK protein degradation; molecular association, regulation; intracellular localization; enzymatic activity, inhibited; protein conformation carcinogenesis, induced; autophagy, induced; cell growth, induced HSC70(INDUCES); PKM(DISRUPTS) Other(DISRUPTS) 21700219; 25645022; 27197174 3 8 30 +Spn sialophorin Cell surface; Membrane protein, integral P15702 20737 7 F3|7 69.35 cM mouse S347-p 477870 RRKSRQGsLVLEELK intracellular localization cell motility, altered 17638845; 21289089 2 33 69 required for T cell trafficking to the lymph nodes; interaction with ezrin, radixin, moesin inhibits T cell migration +Pten PTEN Carbohydrate Metabolism - inositol phosphate; EC 3.1.3.16; EC 3.1.3.48; EC 3.1.3.67; Motility/polarity/chemotaxis; Nuclear receptor co-regulator; PHOSPHATASE; Phosphatase, lipid; Tumor suppressor O08586 19211 19 C1|19 28.14 cM mouse S385-p 448650 RYSDTTDsDPENEPF carcinogenesis, induced; cell motility, induced 22388104 12 10 0 +SLC40A1 SLC40A1 Membrane protein, integral; Membrane protein, multi-pass; Transporter; Transporter, SLC family Q9NP59 30061 2q32.2 human Y20-p 25589102 CCGSLADyLTSAKFL TM receptor internalization, inhibited 22682226 1 0 0 regulates internalization partially but not hepcidin mediated internalization +RECQL4 RECQL4 EC 3.6.4.12; Helicase O94761 9401 8q24.3 human K380-ac 7106309 LLRKQAWkQKWRKKG intracellular localization 19299466 1 0 0 accumulates in the cytoplasm +Sharpin SHARPIN Apoptosis Q91WA6 106025 15 D3|15 35.75 cM mouse K312-ub 21184654 GQSLQNSkMDRKLGL molecular association, regulation signaling pathway regulation ZAP70(INDUCES) 26829767 1 8 0 regulation of TCR signaling-maintenance of immuno; ogical signaling K63-linked polyubiquitination +AVPR2 AVPR2 GPCR, family 1; Membrane protein, integral; Membrane protein, multi-pass; Receptor, GPCR; Transporter; Transporter, aquaporin family P30518 554 Xq28 human S362-p 451067 DESCTTAsSSLAKDT intracellular localization 9482866 1 0 0 After receptor activation, phosphorylation of serines 362, 363, and 364 inhibits overall dephosphorylation of the internalized receptor, thereby inhibiting recycling of the receptor to the cell surface. +Map2k1 MEK1 EC 2.7.12.2; KINASE; Kinase, protein; Protein kinase, STE; Protein kinase, dual-specificity (non-receptor) P31938 26395 9 C|9 34.55 cM mouse S218-p 448514 VSGQLIDsMANSFVG Pkinase molecular association, regulation; enzymatic activity, induced cell growth, altered ERK1(INDUCES) 10749122; 16103085; 7731726; 8090753 124 13 83 +Egr2 EGR2 C2H2-type zinc finger protein; DNA-binding; EC 6.3.2.-; SUMO LIGASE; SUMO conjugating system; SUMO ligase P08152 13654 10 B5.1|10 34.96 cM mouse S349-p 1875113000 EGCDRRFsRSDELTR zf-C2H2 cell growth, induced; transcription, induced 34689593 1 0 0 +PCNA PCNA Cell cycle regulation; DNA replication P12004 5111 20p12.3 human K164-ub 485775 AVVISCAkDGVKFSA PCNA_C protein degradation; molecular association, regulation; ubiquitination cell cycle regulation; carcinogenesis, inhibited; apoptosis, induced; cell growth, inhibited; signaling pathway regulation; DNA repair, induced; DNA repair, altered; apoptosis, inhibited; DNA repair, inhibited POLH(INDUCES); WRNIP1(INDUCES) DNA(INDUCES) 12226657; 16482220; 16957771; 17130289; 18719106; 20129063; 22157819; 22692198; 23076824; 23761444; 26503230; 26549024; 27502483; 27753536; 28458162; 29281621; 30705406; 36228090 33 14 135 AKT inhibitors can by selectively killing homologous recombination (HR)-de?cient cells by inhibition of PCNA ubiquitylation; PCNA drive USP1 dependency in BRCA1/2 mutant tumors, USP1 inhibition and DNA damage leads to apoptosis +HEXIM1 HEXIM1 Motility/polarity/chemotaxis; Transcription factor O94992 10614 17q21.31 human K289-ub 9805701 MSKQELIkEYLELEK HEXIM transcription, inhibited 19617712 1 3 0 +MCOLN1 mucolipin 1 Channel, cation; Membrane protein, integral; Membrane protein, multi-pass; Transporter, ion channel Q9GZU1 57192 19p13.2 human S557-p 1233701 SGKFRRGsGSACSLL activity, inhibited 17988215 1 10 0 +IRF3 IRF3 DNA-binding; Transcription factor Q14653 3661 19q13.33 human K87-ub 25174501 FRSALNRkEGLRLAE IRF protein degradation; molecular association, regulation autophagy, induced CALCOCO2(INDUCES) 37330913 2 0 0 GPR108 and Smurf1 mediated degradation requires NDP52; NDP52-dependent autophagic degradation of phosphorylated IRF3; GPR108 interacts with Smurf1, followed by the recruitment of IRF3 during viral infection +LGALS3 galectin-3 Cell surface; Extracellular matrix; Motility/polarity/chemotaxis P17931 3958 14q22.3 human Y79-p 13213701 GAPAPGVyPGPPSGP protein stabilization carcinogenesis, induced; apoptosis, altered 20150913 2 1 0 +Add1 ADD1 Cytoskeletal; Motility/polarity/chemotaxis Q9QYC0 11518 5 B2|5 17.9 cM mouse S724-p 449829 KKKFRTPsFLKKSKK intracellular localization cell cycle regulation; neural plasticity; cytoskeletal reorganization 23424621; 33771994; 36539904 24 57 158 +AMOTL2 AMOTL2 Cell adhesion Q9Y2J4 51421 3q22.2 human K347-ub 52485000 EKAGRIEkLESEIQR molecular association, regulation; phosphorylation cell growth, inhibited; cell motility, inhibited; transcription, inhibited YAP1(INDUCES); LATS2(INDUCES) 26598551 1 2 0 +RET Ret iso3 EC 2.7.10.1; KINASE; Kinase, protein; Membrane protein, integral; Oncoprotein; Protein kinase, TK; Protein kinase, tyrosine (receptor) Q15300 5979 10q11.21 human Y586-p 447625 TWIENKLyGRISHAF molecular association, regulation SHC1(INDUCES) 9047384 42 2 2 +Cldn5 Claudin-5 Cytoskeletal; Membrane protein, integral; Membrane protein, multi-pass O54942 12741 16 A3|16 11.63 cM mouse T207-p 454390 YSAPRRPtANGDYDK activity, induced cytoskeletal reorganization 15383327 3 1 13 +Hsp90ab1 HSP90B Chaperone; Heat shock protein P11499 15516 17 B3|17 22.59 cM mouse S255-p 449266 PKIEDVGsDEEDDSG HSP90 molecular association, regulation; enzymatic activity, inhibited apoptosis, induced Akt1(DISRUPTS) 34645797 10 131 410 inhibits AKT phosphorylation +PML PML iso4 Nucleolus; Oncoprotein; SUMO LIGASE; SUMO conjugating system; SUMO ligase; Transcription factor; Tumor suppressor; Ubiquitin conjugating system P29590-4 5371 15q24.1 human S530-p 451473 DGPPSPRsPVIGSEV DUF3583 protein stabilization apoptosis, altered 15093545 2 29 17 Phosphorylation of PML is associated with enhanced sumoylation and apoptosis induced by As2O3. +SIRT6 SIRT6 DEACETYLASE; DEUBIQUITINASE; Deacetylase; EC 2.4.2.31; EC 3.5.1.-; Transferase Q8N6T7 51548 19p13.3 human K33-ub 1881229505 PPEELERkVWELARL protein degradation carcinogenesis, induced 33903120 1 0 0 +STXBP5L STXBP5L Q9Y2K9 9515 3q13.33 human S822-p 4724304 RSRSSSIsSIDKDSK Lgl_C protein degradation 25002582 1 4 3 ; in a multiple residue S->D mutant +Dnph1 DNPH1 EC 3.2.2.-; Hydrolase Q80VJ3 381101 17|17 C mouse S17-p 3175250 CSVYFCGsIRGGRED Nuc_deoxyrib_tr enzymatic activity, inhibited 20962348 1 8 0 contibutes to substrate binding and catalysis +OCLN occludin Cell adhesion; Membrane protein, integral; Membrane protein, multi-pass; Motility/polarity/chemotaxis Q16625 100506658 5q13.2 human Y402-p 458611 QDHYETDyTTGGESC molecular association, regulation; intracellular localization ZO1(INDUCES) 19017651 1 4 6 +SIRT2 SIRT2 DEACETYLASE; Deacetylase; EC 3.5.1.- Q8IXJ6 22933 19q13.2 human S25-p 1983913 QEAQDSDsDSEGGAA molecular association, regulation; intracellular localization transcription, induced DNA(DISRUPTS) 29694890 1 26 0 +Cited1 CITED1 Nuclear receptor co-regulator P97769 12705 X D|X 45.25 cM mouse S84-p 27937109 TPSSKPPsFNLHPTP CITED intracellular localization cell differentiation, induced 23529225 1 0 0 S63/64/65/67/69/73/79/80/84A mutation in CITED1 inhibits its translocation into the nucleus and osteoblasts differentiation +FBXL20 FBXL20 UBIQUITIN LIGASE; Ubiquitin ligase Q96IG2 84961 17q12 human S143-p 1875005602 TSLSKFCsKLRHLDL LRR_6 protein degradation; molecular association, regulation carcinogenesis, inhibited; cell growth, inhibited; apoptosis, induced FBXO31(INDUCES) 34587475 1 0 0 +C5AR1 C5aR GPCR, family 1; Membrane protein, integral; Membrane protein, multi-pass; Receptor, GPCR P21730 728 19q13.32 human S327-p 448821 RNVLTEEsVVRESKS molecular association, regulation; receptor desensitization, altered ARRB1(INDUCES); ARRB2(INDUCES) 12464600; 17145764 4 17 37 induces translocation of beta-arrestin into the plasma membrane +SSTR2 SSTR2 GPCR, family 1; Membrane protein, integral; Membrane protein, multi-pass; Receptor, GPCR P30874 6752 17q25.1 human T353-p 7652102 DKSRLNEtTETQRTL receptor internalization, induced; receptor desensitization, induced; receptor recycling, induced 24565897; 24637622 9 0 1 +RACK1 RACK1 Adaptor/scaffold; G protein; G protein, heterotrimeric; G protein, heterotrimeric beta; Motility/polarity/chemotaxis; Nuclear receptor co-regulator P63244 10399 5q35.3 human S278-p 1874704200 KQEVISTsSKAEPPQ WD40 translation, induced 34496247 1 0 0 +WDR44 WDR44 Motility/polarity/chemotaxis; Vesicle Q5JSH3 54521 Xq24 human S344-p 480095 PQRPRSNsGRELTDE molecular association, regulation; protein conformation RAB11A(INDUCES) 36463963 1 15 53 +SREBF2 SREBP-2 DNA-binding; Membrane protein, integral; Membrane protein, multi-pass; Transcription factor Q12772 6721 22q13.2 human S432-p 451007 NQNVLLMsPPASDSG transcription, induced 14988395 1 0 0 +Smad2 SMAD2 DNA-binding; Transcription factor Q62432 17126 18 E3|18 51.42 cM mouse S465-p 447494 SPSVRCSsMS_____ molecular association, regulation; intracellular localization carcinogenesis, induced; cell growth, induced; cell motility, induced; cell growth, inhibited; cell differentiation, induced; transcription, induced; signaling pathway regulation SMAD4(INDUCES) 32122971; 34655614; 34799661; 35538070; 37350664 57 1 5 +Spi1 PU.1 DNA-binding; Oncoprotein; Transcription factor P17433 20375 2 E1|2 50.44 cM mouse S133-p 478390 SPAHQQSsDEEEGER molecular association, regulation IRF8(INDUCES); PU.1(INDUCES); IRF2(INDUCES) 17200120 1 1 0 Interaction of PU.1, IRF-2, and IRF-8 requires phosphorylated residues on each protein. +Bmal1 BMAL1 DNA-binding; Transcription factor Q9WTL8 11865 7 F1|7 59.17 cM mouse S97-p 7359500 RRRDKMNsFIDELAS HLH molecular association, regulation; intracellular localization; protein conformation apoptosis, inhibited; transcription, induced; transcription, altered 19330005; 24312621 3 0 0 critical oxidative stress-responsive circadian transcriptome; regulates circadian gene expression; BMAL1-HSF1 dimerization +ITGB4 ITGB4 Cell adhesion; Membrane protein, integral; Motility/polarity/chemotaxis; Receptor, misc. P16144 3691 17q25.1 human S1325-p 3103700 TQPKRPMsIPIIPDI molecular association, regulation Plectin-1(INDUCES) 15817481 1 0 0 +ACTR3 Arp3 Cytoskeletal; Motility/polarity/chemotaxis P61158 10096 2q14.1 human S418-p 480945 NPVFGVMs_______ cell motility, induced; cytoskeletal reorganization 37057894 1 19 0 +RIPK2 RIPK2 EC 2.7.10.2; EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, Ser/Thr (non-receptor); Protein kinase, TKL; Protein kinase, tyrosine (non-receptor) O43353 8767 8q21.3 human K209-ub 2793000 QKSRASIkHDIYSYA PK_Tyr_Ser-Thr molecular association, regulation signaling pathway regulation TAK1(INDUCES); TAB2(INDUCES); XIAP(DISRUPTS); TAB1(INDUCES); IKKG(INDUCES) 18079694; 32954645 3 1 0 mutagenesis of K209 blocks RIPK2 ubiquitination and inflammatory signaling by displacing XIAP; authors did not detect ubiquitination of RIPK2 K209 during NOD2 signaling; regulation Nod1-Nod2 and RIPK2 polyubiquitylation-mediated NF-kB activation and secretion of chemokines +Cacna1a CACNA1A Channel, calcium; Membrane protein, integral; Membrane protein, multi-pass P97445 12286 8 C2|8 40.95 cM mouse S2361-p 4713048 RGAHDAYsESEDDWC activity, induced 32630015 1 4 0 regulates Ca2+ entry and insulin secretion in pancreatic-beta cells +Bmf BMF Apoptosis; Cytoskeletal Q91ZE9 171543 2|2 E5 mouse S74-p 11267001 DKATQTLsPASPSQG BMF activity, induced apoptosis, altered; apoptosis, induced 19841067; 29141222 5 0 0 partially contributes to anoikis; required for normal lymphocyte homeostasis +RAPH1 RAPH1 Adaptor/scaffold; Motility/polarity/chemotaxis Q70E73 65059 2q33.2 human S1069-p 1883958000 VEFPSPPsDSDFPPP intracellular localization cell motility, induced VASP(DISRUPTS) 37632751 1 1 0 regulates MENA localization +Rps6kb1 p70S6K EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, AGC; Protein kinase, Ser/Thr (non-receptor); Translation P67999 83840 10q26 rat S40-p 450117 DQPEDAGsEDELEEG molecular association, regulation Exportin-1(INDUCES) 16895915 2 1 6 +PPP2CA PPP2CA EC 3.1.3.16; Motility/polarity/chemotaxis; PHOSPHATASE; Protein phosphatase, Ser/Thr (non-receptor) P67774 cow L309-me 3627520 RRTPDYFl_______ enzymatic activity, induced 26569399 10 0 0 +Ntrk3 TrkC EC 2.7.10.1; KINASE; Kinase, protein; Membrane protein, integral; Protein kinase, TK; Protein kinase, tyrosine (receptor) Q03351 29613 1q31 rat Y859-p 451749 LGKATPIyLDILG__ molecular association, regulation PLCG1(INDUCES); SHC1(INDUCES) 7657612 2 0 0 +ZNF76 ZNF76 C2H2-type zinc finger protein P36508 7629 6p21.31 human K411-sm 2798302 IAYLSEVkEERDDIP molecular association, regulation; activity, inhibited transcription, altered TBP(DISRUPTS) 15280358; 16337145 2 0 0 +H3C1 H3 DNA-binding P68431 8350 6p22.2 human K27-ac 465521 LATKAARkSAPATGG Histone acetylation; molecular association, regulation; intracellular localization cell differentiation, inhibited; cell cycle regulation; carcinogenesis, induced; carcinogenesis, inhibited; apoptosis, induced; transcription, induced; transcription, altered; DNA repair, induced; chromatin organization, altered; transcription, inhibited BRD4(INDUCES); TIF1G(INDUCES) DNA(INDUCES); DNA(DISRUPTS) 20385584; 20720004; 21282660; 21726812; 23287868; 25941994; 26286207; 28630323; 28671020; 28716899; 28751304; 28953875; 32079144; 35222362; 35792897; 36060800; 37638746 74 18 13 +EGFR EGFR EC 2.7.10.1; KINASE; Kinase, protein; Membrane protein, integral; Oncoprotein; Protein kinase, TK; Protein kinase, tyrosine (receptor) P00533 1956 7p11.2 human K823-ub 1065314 NWCVQIAkGMNYLED PK_Tyr_Ser-Thr protein degradation 17940017 1 1 0 +SKP2 SKP2 Cell cycle regulation; UBIQUITIN LIGASE; Ubiquitin conjugating system; Ubiquitin ligase Q13309 6502 5p13.2 human S64-p 457412 SNLGHPEsPPRKRLK activity, induced; protein stabilization; molecular association, regulation; ubiquitination; phosphorylation cell cycle regulation; carcinogenesis, induced; cell growth, induced; transcription, induced CDH1(DISRUPTS); NKX3-1(INDUCES) 18239684; 20663873; 27065334; 33793628 6 28 2 +Llgl1 LLGL1 Cell adhesion; Cytoskeletal; Motility/polarity/chemotaxis Q80Y17 16897 11 B2|11 37.81 cM mouse S658-p 449916 RVKSLKKsLRQSFRR intracellular localization 11809830 2 10 7 +Mknk1 Mnk1 EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, CAMK; Protein kinase, Ser/Thr (non-receptor); Translation O08605 17346 4|4 D1 mouse T214-p 447622 ITTPELTtPCGSAEY Pkinase molecular association, regulation; enzymatic activity, induced eIF4G(INDUCES) 10022874 13 1 0 +GFAP GFAP Cytoskeletal P14136 2670 17q21.31 human S8-p 449618 MERRRITsAARRSYV Filament_head molecular association, regulation; protein stabilization fascin(INDUCES) 12177195; 19170683 9 0 0 +ITSN1 ITSN1 Adaptor/scaffold; Calcium-binding; GEF; GEF, Rac/Rho Q15811 6453 21q22.11 human T832-p 280867300 PKLALREtPAPLAVT INTAP molecular association, regulation; intracellular localization SYN1(INDUCES) 29078407 1 0 0 presynaptic nanoscale distribution of synapsin I +LIMA1 eplin Actin-binding; Cytoskeletal; Motility/polarity/chemotaxis Q9UHB6 51474 12q13.12 human S604-p 459750 FQSTSVKsPKTVSPP protein degradation; ubiquitination carcinogenesis, induced; cell adhesion, induced; cytoskeletal reorganization; cell motility, inhibited 23188829; 28465438 3 29 16 E-cadherin down regulation, EMT; formation of large plasma membrane ruffles that are characterized by highly dynamic actin rearrangements in their lamellipodia +HNRNPUL1 E1B-AP5 RNA splicing; RNA-binding Q9BUJ2 11100 19q13.2 human R645-m2 15381101 NRGGFQNrGGGSGGG molecular association, regulation; intracellular localization NBS1(INDUCES) 26020839 1 2 14 ecruitment at sites of damage +FERMT2 kindlin-2 Cytoskeletal; Motility/polarity/chemotaxis Q96AC1 10979 14q22.1 human S181-p 3208614 GSGSIYSsPGLYSKT protein degradation; molecular association, regulation; ubiquitination cell cycle regulation; cell growth, induced; apoptosis, inhibited; cytoskeletal reorganization; cell adhesion, inhibited CUL9(INDUCES) 25646088; 35469017 2 3 4 +NRF1 NRF1 DNA-binding; Transcription factor Q16656 4899 7q32.2 human K230-ub 1878066500 GWGKESCkPIWWPED protein degradation carcinogenesis, induced; cell growth, induced; transcription, altered 30833558 1 0 0 under hypoxia +Hspa1a HSP70 Chaperone; Heat shock protein; Motility/polarity/chemotaxis Q61696 193740 17 B1|17 18.51 cM mouse R416-me 1877047301 VMTALIKrNSTIPTK HSP70 protein stabilization carcinogenesis, induced; cell growth, induced; apoptosis, inhibited RNA(INDUCES) 32699135 1 1 0 binding and stabilization of BCL2 mRNA +NSD2 WHSC1 Amino Acid Metabolism - lysine degradation; EC 2.1.1.43; METHYLTRANSFERASE; Methyltransferase; Methyltransferase, protein lysine; Oncoprotein; Ubiquitin conjugating system O96028 7468 4p16.3 human S172-p 478693 ARRNRKRsIKYDSLL protein stabilization cell motility, inhibited CUL4B(DISRUPTS) 28319045 1 7 50 prostate cancer metastasis +FOXM1 FOXM1 DNA-binding; Transcription factor Q08050 2305 12p13.33 human K422-ac 57807002 KRVRIAPkVLLAEEG activity, induced; protein stabilization; molecular association, regulation; phosphorylation carcinogenesis, induced; cell growth, induced; transcription, induced DNA(NOT_REPORTED) 27542221 1 1 0 +SPRED2 SPRED2 Motility/polarity/chemotaxis; Vesicle Q7Z698 200734 2p14 human Y231-p 471404 WMTGYEDyRHAPVRG protein degradation 17094949 1 1 7 Pervanadate induced Spred-2 degredation in ME4405 cells which is dependent on ubiquitination. +Ms4a2 FcER1B Membrane protein, integral; Membrane protein, multi-pass; Receptor, misc. P13386 25316 1q43 rat Y228-p 2883702 LHVYSPIySALEDTR molecular association, regulation GRB2(INDUCES); SHIP(INDUCES); Syk(INDUCES); SHC1(INDUCES); SHP-1(INDUCES) 17365510 1 1 0 SHIP binding is senstive to the presence of Syk. +PDCD5 PDCD5 Apoptosis O14737 9141 19q13.11 human K98-ub 3934349 GLIEILKkVSQQTEK dsDNA_bind protein degradation apoptosis, inhibited 25499082 1 2 8 +Gap43 GAP43 Cell surface P07936 29423 11q21 rat S41-p 448719 AATKIQAsFRGHITR IQ cytoskeletal reorganization; cell adhesion, altered; cell growth, altered 19249369 14 9 5 binds and stabilizes F-actin filaments +Irf3 IRF3 DNA-binding; Transcription factor P70671 54131 7|7 B3 mouse S378-p 448696 MAREGGAsSLKTVDL transcription, induced; signaling pathway regulation 33710283; 33976210; 35082159 12 3 0 +TP53BP2 53BP2 Transcription, coactivator/corepressor Q13625 7159 1q41 human Y874-p 36747001 PPYPPPPyPSGEPEG protein degradation; molecular association, regulation; intracellular localization; phosphorylation transcription, induced 53BP2(INDUCES) 25360797 1 0 0 promotes the dephosphorylation of YAP +PIP5K1B PIP5K1B Carbohydrate Metabolism - inositol phosphate; EC 2.7.1.68; Kinase, lipid O14986 8395 9q21.11 human Y105-p 9471801 FGIKPDDyLYSICSE intracellular localization; enzymatic activity, inhibited cytoskeletal reorganization 19553680 1 0 0 +PTGES3 TEBP Chaperone; EC 5.3.99.3; Isomerase; Nuclear receptor co-regulator; Transferase Q15185 10728 12q13.3|12 human S118-p 451130 DDSDEDMsNFDRFSE molecular association, regulation; enzymatic activity, induced HSP90A(INDUCES); CK2A1(INDUCES) 15040786 1 18 3 +KIT Kit EC 2.7.10.1; KINASE; Kinase, protein; Membrane protein, integral; Oncoprotein; Protein kinase, TK; Protein kinase, tyrosine (receptor) P10721 3815 4q12 human Y721-p 448017 CSDSTNEyMDMKPGV PK_Tyr_Ser-Thr activity, induced cell adhesion, altered 15654360; 21887372 18 5 52 +Pard3 PAR3-alpha Adaptor/scaffold; Motility/polarity/chemotaxis Q9Z340 81918 19q12 rat S1116-p 28758704 ALNARPQsPREGHLM molecular association, regulation; intracellular localization cytoskeletal reorganization KIF3A(DISRUPTS) 23946386 1 3 0 S1116-p inhibits transport of Par3 toward the distal part of axon and regulates polarity. +KCNH2 Kv11.1 Channel, potassium; Membrane protein, integral; Membrane protein, multi-pass; Motility/polarity/chemotaxis Q12809 3757 7q36.1 human T895-p 4974500 KLSFRRRtDKDTEQP activity, inhibited signaling pathway regulation 10488078; 10837251; 18791070 4 0 1 +ARPP19 ARPP-19 Cell cycle regulation; Phosphatase, regulatory subunit P56211 10776 15q21.2 human S62-p 465742 KGQKYFDsGDYNMAK Endosulfine molecular association, regulation; enzymatic activity, inhibited cell cycle regulation PPP2CA(INDUCES) 30626720; 32085646 3 70 47 +DICER1 DICER1 Cell development/differentiation; EC 3.1.26.3; Helicase; RNA processing; RNA-binding; Ribonuclease Q9UPY3 23405 14q32.13 human S1728-p 114810400 YEDPRQHsPGVLTDL Ribonuclease_3 DNA repair, induced 28642363 1 1 0 +ANTXR2 ANTXR2 Membrane protein, integral; Receptor, misc. P58335 118429 4q21.21 human Y381-p 3697372 PTVDASYyGGRGVGG ubiquitination 20080640 1 4 42 +Il3ra IL3RA Membrane protein, integral P26952 16188 14 A1|14 7.08 cM mouse K357-ub 1877015603 GLLLWWRkSLLYRLC protein degradation 31990690 2 0 0 lung innate immunity and in?ammation in vivo +BCL3 Bcl-3 Apoptosis; Nuclear receptor co-regulator; Oncoprotein; Transcription regulation P20749 602 19q13.32 human S122-p 143278600 CPMEHPLsADIAMAT cell motility, induced; transcription, induced 28689659 1 1 0 +Ptk2 FAK iso2 EC 2.7.10.2; KINASE; Kinase, protein; Protein kinase, TK; Protein kinase, tyrosine (non-receptor) P34152-2 14083 15 D3|15 33.94 cM mouse Y956-p 447966 DRSNDKVyENVTGLV Focal_AT molecular association, regulation; enzymatic activity, induced; phosphorylation cell motility, altered; cytoskeletal reorganization; cell adhesion, altered; cell growth, altered PXN(DISRUPTS); PXN(INDUCES) 18606490; 20159040 104 17 427 regulates VEGF expression and ERK phosphorylation; axon remodeling, disassembly from paxillin +Gria1 GluR1 Channel, calcium; Channel, ligand-gated; Membrane protein, integral; Membrane protein, multi-pass P23818 14799 11 B1.3|11 34.51 cM mouse K886-ub 40320201 VVSQDFPkSMQSIPC protein degradation; receptor internalization, inhibited 28212375 3 0 0 regulation of Nedd4-2 mediated spontaneous neuronal activity and seizure susceptibility +LALBA LALBA Apoptosis; Secreted; Secreted, signal peptide; Transferase P00711 281894 cow S41-p 1875112300 LKGYGGVsLPEWVCT Lys molecular association, regulation; protein conformation IGE(DISRUPTS); IgG(DISRUPTS) 34655828 0 1 0 +TERT TERT iso3 DNA-binding; EC 2.7.7.49; Nucleolus; Transferase O14746-3 7015 5p15.33 human K94-ub 14561000 RLCERGAkNVLAFGF protein degradation chromatin organization, altered; apoptosis, induced 20453884 1 0 0 +Gab2 GAB2 Adaptor/scaffold Q9Z1S8 14389 7|7 E1 mouse Y632-p 450913 TSDEKVDyVQVDKEK molecular association, regulation cell differentiation, altered; cell growth, altered SHP-2(INDUCES) 11287610 4 11 190 +FRAT1 FRAT1 Oncoprotein; Transcription regulation Q92837 10023 10q24.1 human S188-p 471366 RLQQRRGsQPETRTG GSK-3_bind protein degradation; activity, inhibited transcription, inhibited 16982607 1 0 0 phosphorylation of this site inhibits FRAT1 activity (towards GSK3beta) and reduces its ability to activate beta catenin-TCF/LEF-dependent transcription +LAX1 LAX1 Adaptor/scaffold; Membrane protein, integral Q8IWV1 54900 1q32.1 human Y193-p 35546000 SSEDSHDyVNVPTAE LAX molecular association, regulation transcription, inhibited; signaling pathway regulation GRB2(INDUCES); GADS(INDUCES); PIK3R1(INDUCES) 12359715 1 0 0 +Nr3c1 GR DNA-binding; Mitochondrial; Nuclear receptor; Transcription factor P06537 14815 18 B3|18 21.09 cM mouse K435-ub 485771 TATGPPPkLCLVCSD zf-C4 protein degradation transcription, inhibited 11555652 1 0 0 +DDB2 DDB2 DNA repair, damage Q92466 1643 11p11.2 human K77-ac 1876931103 VRTLHQHkLGRASWP DNA repair, induced 32789493 1 1 0 SIRT6 as a critical factor in the regulation of the process of UV-induced DNA damage repair +Prkca PKCA EC 2.7.11.13; KINASE; Kinase, protein; Oncoprotein; Protein kinase, AGC; Protein kinase, Ser/Thr (non-receptor) P05696 24680 10q32.1 rat S657-p 448597 QSDFEGFsYVNPQFV Pkinase_C signaling pathway regulation 23490331 28 4 2 diabetes-type1 and type2-related signaling in brain +MME CD10 EC 3.4.24.11; Membrane protein, integral; Protease P08473 4311 3q25.2 human S6-p 3850156 __MGKSEsQMDITDI protein stabilization; molecular association, regulation; intracellular localization; phosphorylation PTEN(DISRUPTS) 20957047; 22767595 2 14 19 regulates cell surface neprilysin localization and A? stability; phosphorylation of this site (MME S6D mutant) increases insulin/IGF-1 stimulated activation of Akt +TOP2A TOP2A EC 5.99.1.3; Isomerase P11388 7153 17q21.2 human S1361-p 455094 SPPKTKTsPKLSNKE protein degradation; molecular association, regulation; ubiquitination FBXW7(INDUCES) 21254166 2 1 0 +LIFR LIFR Membrane protein, integral; Receptor, cytokine P42702 3977 5p13.1 human K880-ac 62856002 IPNPENCkALQFQKS protein conformation 28122243 1 1 0 ESC pluripotency in vivo +TP53BP1 53BP1 DNA repair, damage; Transcription, coactivator/corepressor Q12888 7158 15q15.3 human R1400-me 2344820 VTPRGRGrRGRPPSR molecular association, regulation DNA(INDUCES) 16294045 2 0 0 +Upf1 RENT1 C2H2-type zinc finger protein; EC 3.6.1.-; EC 3.6.4.-; Hydrolase; RNA-binding Q9EPU0 19704 8 B3.3|8 34.15 cM mouse T28-p 21560213 AELLGADtQGSEFEF molecular association, regulation; phosphorylation; enzymatic activity, induced RNA splicing, induced; RNA stability, inhibited; translation, induced; signaling pathway regulation MCPIP1(INDUCES) 31329944 3 0 0 Regnase mRNA decay induced by phosphorylation of RENT1-T28, Regnase-1 deficiency upregulates target mRNAs at the pioneer round of translation. SMG1-Regnase-1 pathway +CDCA5 CDCA5 Cell cycle regulation Q96FF9 113130 11q13.1 human S33-p 472118 LRRSQRKsGSELPSI activity, inhibited cell cycle regulation SCC-112(DISRUPTS) 23901111 1 8 2 +Mapk7 ERK5 EC 2.7.11.24; KINASE; Kinase, protein; Protein kinase, CMGC; Protein kinase, Ser/Thr (non-receptor) Q9WVS8 23939 11|11 B2 mouse S764-p 14561006 QADSASLsASLLADW transcription, altered 17928297 2 1 0 +H3C1 H3 DNA-binding P68431 8350 6p22.2 human K79-m2 1458615 REIAQDFkTDLRFQS Histone protein stabilization; molecular association, regulation; methylation; protein conformation carcinogenesis, induced; carcinogenesis, inhibited; cell growth, induced; chromatin organization, altered; transcription, induced; transcription, altered; transcription, inhibited L3MBTL iso4(INDUCES); DOT1L(INDUCES); 53BP1(INDUCES) 17190600; 18794842; 18977325; 19734945; 19805358; 20348416; 23361907; 23412334; 23583077; 31727944; 35172132 40 21 10 ubiquitin and nucleosome acidic patch binding by DOT1L are required for cell proliferation in a leukemia model; regulation genes that control the host-response against infection which can be modulated by Pinometostat +Notch1 Notch 1 Membrane protein, integral; Motility/polarity/chemotaxis; Oncoprotein; Receptor, misc.; Transcription factor Q01705 18128 2 A3|2 18.91 cM mouse K2161-ac 18899507 KGLACGSkEAKDLKA protein stabilization; ubiquitination 21499261 1 2 0 +Kif11 KIF11 Microtubule-binding; Motor F1MAB8 rat T926-p 448410 LDIPTGMtPERKNYL Microtub_bind molecular association, regulation cytoskeletal reorganization TUBB3(INDUCES) 25355946 8 29 2 association with tyrosinated microtubules +SNRPB snRNP B1 RNA processing; RNA splicing; RNA-binding; Spliceosome P14678 6628 20p13 human R108-m2 476753 AGGPGIGrAAGRGIP molecular association, regulation SMN(INDUCES) 11720283 1 7 26 +FAF1 FAF1 Apoptosis; Nuclear receptor co-regulator Q9UNN5 11124 1p32.3 human S291-p 450287 DVHMVSDsDGDDFED intracellular localization cell cycle regulation 12832043; 18790738; 27662363 3 2 0 mediates the proteasome-dependent degradation of AurA; nuclear localization; induces G2/M arrest +Cttn Cortactin Actin-binding; Cytoskeletal; Motility/polarity/chemotaxis Q60598 13043 7|7 F5 mouse K193-ac 1880005101 ESQKDYSkGFGGKYG molecular association, regulation; acetylation; intracellular localization DIP2A(INDUCES) 31600191 1 0 0 DIP2A regulates spine morphology and synaptic transmission through acetylation of cortactin; Interaction of DIP2A-cortactin is required for acetylated cortactin; acetylation mimetic cortactin rescues the repetitive behaviors in Dip2a KO mice; acetylation alleviated abnormal PSD95 clustering at the spine head in DIP2A KO neurons +KCNJ11 Kir6.2 Channel, potassium; Membrane protein, integral; Membrane protein, multi-pass Q14654 3767 11p15.1 human T180-p 450652 QAHRRAEtLIFSKHA receptor internalization, induced 23223335 2 0 0 +CIB1 CIB1 Cell adhesion; Motility/polarity/chemotaxis Q99828 10519 15q26.1 human K10-ub 21171746 GSGSRLSkELLAEYQ protein degradation cell motility, inhibited 33082516 1 6 0 +IRS1 IRS1 Adaptor/scaffold; Motility/polarity/chemotaxis P35568 3667 2q36.3 human S24-p 455604 GYLRKPKsMHKRFFV PH molecular association, regulation PIK3C2A(INDUCES); INSR(INDUCES) 15849359 2 2 0 +Trim28 TIF1B EC 6.3.2.-; KINASE; Kinase, protein; Ligase; Nuclear receptor co-regulator; Protein kinase, atypical; SUMO LIGASE; SUMO ligase; Transcription, coactivator/corepressor; UBIQUITIN LIGASE; Ubiquitin conjugating system; Ubiquitin ligase Q62318 21849 7|7 A1 mouse K750-sm 3142606 IRARLQEkLSPPYSS transcription, inhibited 17298944 2 8 0 +SLC22A6 SLC22A6 Membrane protein, integral; Membrane protein, multi-pass; Transporter; Transporter, SLC family Q4U2R8 9356 11q12.3 human K297-ub 53529106 RVARINGkREEGAKL Sugar_tr receptor internalization, induced 23640180 1 0 0 +Gys2 GYS2 Carbohydrate Metabolism - starch and sucrose; Cytoskeletal; EC 2.4.1.11; Transferase P17625 25623 4q44 rat S8-p 484503 MLRGRSLsVTSLGGL intracellular localization; enzymatic activity, inhibited 19124463 1 8 0 translocation dependent on glycogen synthesis +AIP AIP Nuclear receptor co-regulator; Transcription, coactivator/corepressor O00170 9049 11q13.2 human S131-p 10888701 VAQMREHsSLGHADL molecular association, regulation HSP90A(INDUCES) 12361709 2 0 0 +TP53BP1 53BP1 DNA repair, damage; Transcription, coactivator/corepressor Q12888 7158 15q15.3 human S1342-p 3194873 GPLRGKTsGTEPADF intracellular localization 28415769 1 5 1 recruitment at kinetochores during mitosis +RORA RORA DNA-binding; Nuclear receptor P35398 6095 15q22.2 human K240-sm 6124702 GLDINGIkPEPICDY transcription, induced 19041634 1 0 0 +MAPT Tau iso8 ACETYLTRANSFERASE; Acetyltransferase; Cytoskeletal P10636-8 4137 17q21.31 human S202-p 447928 SGYSSPGsPGTPGSR O-GlcNAc glycosylation; molecular association, regulation; intracellular localization; protein conformation; phosphorylation cytoskeletal reorganization ubiquitin(INDUCES); Fyn(DISRUPTS); Tau iso8(INDUCES); CRMP-2(INDUCES); Tau(INDUCES) 12414518; 14761950; 15190058; 15364924; 15664690; 16115884; 16923168; 18725412; 19451179; 20550628; 24312574; 26161867; 28758999; 31543505; 32019603; 33952699; 35610289; 37488165 175 57 116 +EPRS1 EPRS Aminoacyl-tRNA synthetase; Cofactor and Vitamin Metabolism - porphyrin and chlorophyll; EC 6.1.1.15; EC 6.1.1.17; Ligase; Translation; Translation regulation P07814 2058 1q41 human S990-p 58109406 DGQRKDPsKNQGGGL molecular association, regulation hnRNP E2(INDUCES) 27595231 1 1 0 dissociation multi-tRNA synthetase complex (MSC) ; blocked PCBP2-mediated ubiquitination of MAVS +MAGI1 MAGI1 Cell adhesion; Motility/polarity/chemotaxis Q96QZ7 9223 3p14.1 human K931-sm 1871464502 KVVFAVPkTENEVPS signaling pathway regulation 33304925 2 0 0 K931 sumoylation prevents localization and stabilizes the barrier; p90RSK-mediated MAGI1 PTMs and the Hippo pathway signaling +SLN sarcolipin Endoplasmic reticulum; Membrane protein, integral O00631 6588 11q22.3 human T5-p 459214 ___MGINtRELFLNF Sarcolipin molecular association, regulation; protein conformation ATP2A1(DISRUPTS) 23455424; 27378083; 32668157 6 0 0 Decrease correlation between N-Terminal and C-Terminal domains; in vitro; Pentameric phospho-SLN promotes penetration of monovalent and divalent ions through the channel. +HSF1 HSF1 DNA-binding; Transcription factor Q00613 3297 8q24.3 human K298-sm 3656302 SSPLVRVkEEPPSPP Vert_HS_TF sumoylation; molecular association, regulation; intracellular localization transcription, inhibited DNA(INDUCES) 11514557; 16371476; 19597476 7 1 0 +FYB1 SLAP-130 Adaptor/scaffold O15117 2533 5p13.1 human Y771-p 449430 ADNDGEIyDDIADGC hSH3 molecular association, regulation cell adhesion, induced; cell motility, altered; cell adhesion, altered SLP76(INDUCES) 20661443; 23979596 4 3 68 +Plin5 perilipin 5 Q8BVZ1 66968 17|17 D mouse S155-p 8095494 AQRGRRWsGELRRSM Perilipin molecular association, regulation; intracellular localization ABHD5(DISRUPTS); PNPLA2(INDUCES) 28919478; 33334871 3 8 1 regulation of lipolysis and fatty acid beta-oxidation; important for PKA-dependent lipolysis; regulation of glycemic control +PPP3CB PPP3CB EC 3.1.3.16; PHOSPHATASE; Protein phosphatase, Ser/Thr (non-receptor) P16298 5532 10q22.2 human K327-ub 1878212800 YLDVYNNkAAVLKYE cell cycle regulation; cell growth, inhibited; transcription, inhibited 31135381 1 1 0 USP16 regulates T cell proliferation and cell-cycle entry; Ubiquitination of PPP3CB impairs NFAT recruitment and transcription of NFAT-targeted genes +Nfkb1 NFkB-p105 DNA-binding; Transcription factor P25799 18033 3 G3|3 62.82 cM mouse S240-p 34354490 VSDAIYDsKAPNASN RHD_DNA_bind molecular association, regulation; protein conformation transcription, altered DNA(DISRUPTS) 29873020 1 1 1 +SH3BP2 SH3BP2 Adaptor/scaffold P78314 6452 4p16.3 human S225-p 455469 SDMPRAHsFTSKGPG molecular association, regulation 14-3-3 theta(INDUCES) 12501243 1 9 0 +PTEN PTEN iso2 Carbohydrate Metabolism - inositol phosphate; EC 3.1.3.16; EC 3.1.3.48; EC 3.1.3.67; Motility/polarity/chemotaxis; Nuclear receptor co-regulator; PHOSPHATASE; Phosphatase, lipid; Tumor suppressor P60484-2 5728 10q23.31 human K239-ub 27205468 SKHKNHYkIYNLCAE protein degradation 31685992 3 3 0 +G6PD G6PD Carbohydrate Metabolism - pentose phosphate pathway; Cell development/differentiation; EC 1.1.1.49; Other Amino Acids Metabolism - glutathione; Oxidoreductase P11413 2539 Xq28 human K408-ac 33364576 YTKMMTKkPGMFFNP G6PD_C enzymatic activity, altered 37798264 1 3 0 +Mapk9 JNK2 EC 2.7.11.24; KINASE; Kinase, protein; Protein kinase, CMGC; Protein kinase, Ser/Thr (non-receptor) Q9WTU6 26420 11|11 B1.2-B1.3 mouse Y185-p 447652 TNFMMTPyVVTRYYR Pkinase enzymatic activity, induced apoptosis, induced; cell motility, induced; transcription, inhibited 16061178; 18032450; 26306048 75 39 1441 GTS sequence motif within the activation loop offers a higher phosphorylation efficiency and therefore functional activation of JNK1 over JNK2.; Fyn and thapsigargin-induced cell death; transcription leading to gene expression, epithelial cell migration and eyelid closure. +Cttn Cortactin Actin-binding; Cytoskeletal; Motility/polarity/chemotaxis Q60598 13043 7|7 F5 mouse S405-p 447700 KKQTPPAsPSPQPIE cell cycle regulation; cell motility, altered 18515860 18 87 128 +KCND2 Kv4.2 Channel, potassium; Membrane protein, integral; Membrane protein, multi-pass Q9NZV8 3751 7q31.31 human S552-p 450462 VSGSHQGsIQELSTI protein stabilization; intracellular localization 20045463 6 8 0 KCNIP4-mediated enhancement of channel surface expression +Brsk2 BRSK2 EC 2.7.11.1; EC 2.7.11.26; KINASE; Kinase, protein; Protein kinase, CAMK; Protein kinase, Ser/Thr (non-receptor) Q69Z98 75770 7|7 F5 mouse T444-p 17551641 PRGSPLPtPKGTPVH protein stabilization; enzymatic activity, inhibited; phosphorylation 23790753 2 2 0 inhibits axon branching (activated in BRSK2 18A mutant) +FAAP20 FAAP20 iso2 Q6NZ36 199990 1p36.33 human S48-p 1868139203 AELLRTVsPELILDH FANCA_interact protein stabilization; molecular association, regulation; protein conformation signaling pathway regulation PIN1(INDUCES) 30789902 1 1 0 PIN1 interaction regulate the FBW7 proteolytic signaling ; isomerization of pFAAP20 by PIN1 +PSEN1 PSEN1 Cell surface; EC 3.4.23.-; Membrane protein, integral; Membrane protein, multi-pass; Mitochondrial; Protease P49768 5663 14q24.2 human T320-p 3397302 SKYNAEStERESQDT Presenilin protein stabilization; enzymatic activity, induced 18667537 1 0 0 +Gabrb1 GABRB1 Channel, chloride; Channel, ligand-gated; Membrane protein, integral; Membrane protein, multi-pass; Transporter; Transporter, ion channel P50571 14400 5 C3.2|5 38.18 cM mouse S410-p 10296601 QYRKPLSsREGFGRG Neur_chan_memb activity, induced 10195104 1 0 0 +DLG4 PSD-95 Adaptor/scaffold P78352 1742 17p13.1 human S295-p 456936 PTSPRRYsPVAKDLL PDZ_assoc neural plasticity 34665640 4 12 0 +PRKCD PKCD EC 2.7.11.13; KINASE; Kinase, protein; Nuclear receptor co-regulator; Protein kinase, AGC; Protein kinase, Ser/Thr (non-receptor); Protein kinase, tyrosine (non-receptor); Tumor suppressor Q05655 5580 3p21.1 human S645-p 448591 LNEKARLsYSDKNLI Pkinase_C sumoylation; intracellular localization carcinogenesis, induced 28237688; 34089566; 34155348 29 51 79 +MARCHF5 MARCH5 EC 6.3.2.-; EC 6.3.2.19; Ligase; Membrane protein, integral; Membrane protein, multi-pass; UBIQUITIN LIGASE; Ubiquitin conjugating system; Ubiquitin ligase Q9NX47 54708 10q23.32-q23.33 human K268-ub 15392450 YLRQAHRkILNYPEQ intracellular localization autophagy, induced 31602805 1 2 1 MARCH5 is required for MITOL relocation to peroxisomes +USF1 USF1 DNA-binding; Transcription factor P22415 7391 1q23.3 human K235-ac 7378203 DCSMESTkSGQSKGG HLH molecular association, regulation; intracellular localization transcription, induced SMARCD3(INDUCES) 23219531 2 1 0 K235 acetylation induces recruitment of SMARCD3 to the promoters of lipogenic genes +Rab13 RAB13 G protein; G protein, monomeric; G protein, monomeric, Rab Q9DD03 68328 3 F1|3 39.21 cM mouse K58-ub 964538718 DIEGKRIkLQVWDTA Ras molecular association, regulation GDI1(DISRUPTS) 35343654 1 1 0 Promotes the Post-Golgi Tra?cking of TLR4 and TLR9 +CERT1 COL4A3BP EC 2.7.11.9; KINASE; Kinase, protein; Lipid-binding; Protein kinase, Ser/Thr (non-receptor); Protein kinase, atypical Q9Y5P4 10087 5q13.3 human S135-p 4777474 RRHGSMVsLVSGASG molecular association, regulation; intracellular localization; activity, inhibited 28652409; 33347465 1 7 1 reduced PtdIns(4)P binding affinity as well as low ceramide transfer activity, E494R/N495K/P535R/E537K mutations, recovery of both PtdIns(4)P binding and ceramide transfer activity.; Regulates de novo SM synthesis +KNSTRN TRAF4AF1 Q9Y448 90417 15q15.1 human Y87-p 3583497 TSVVKTVySLQPPSA intracellular localization 33510346 1 1 2 +AURKB AurB EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, Other; Protein kinase, Ser/Thr (non-receptor) Q96GD4 9212 17p13.1 human K87-sm 25087010 GRPLGKGkFGNVYLA Pkinase phosphorylation; enzymatic activity, induced 21554500 1 0 0 induces phosphorylation at T232 +Deaf1 DEAF1 Motility/polarity/chemotaxis; Transcription, coactivator/corepressor Q9Z1T5 54006 7|7 F5 mouse T435-p 34734306 AVPPSTPtKAVSPTV protein stabilization; molecular association, regulation LMO4(INDUCES) 25310299 1 0 1 +LEPR LEPR Membrane protein, integral; Receptor, cytokine P48357 3953 1p31.3 human Y1079-p 451292 NDKKSIYyLGVTSIK activity, induced transcription, induced 17726024 7 0 0 +NFATC1 NFAT2 DNA-binding; Transcription factor O95644 4772 18q23 human K349-sm 6413903 QPPSVALkVEPVGED molecular association, regulation; intracellular localization chromatin organization, altered; transcription, inhibited HDAC1(INDUCES); HDAC2(INDUCES); PML(INDUCES); HDAC4(INDUCES) 19218564 3 1 0 +Elk3 ELK3 DNA-binding; Transcription factor P41971 13713 10 C2|10 48.04 cM mouse S359-p 450031 IHFWSSLsPVAPLSP activity, induced; intracellular localization transcription, altered; cell growth, altered 11042694; 18356083 2 0 0 pro-B cell expansion +Npr2 ANPB EC 4.6.1.2; Guanylyl cyclase; KINASE; Kinase, protein; Lyase; Membrane protein, integral; Nucleotide Metabolism - purine; Protein kinase, RGC; Protein kinase, dual-specificity (receptor); Receptor, misc. P16067 116564 5q22 rat S489-p 25528502 MLEKELAsMLWRIRW enzymatic activity, induced 22590601 1 0 0 +PSRC1 PSRC1 Q6PGN9 84722 1p13.3 human S225-p 18963102 AKLRVSGsGEFVGLT cytoskeletal reorganization 21473853 1 1 0 +Shtn1 SHOT1 Unknown function A0MZ67 292139 1q55 rat S249-p 485709 QNKLKRQsHLLLQSS molecular association, regulation; intracellular localization cell motility, induced; cytoskeletal reorganization Cortactin(INDUCES) 23453953; 26261183 4 19 4 SHOT1 phosphorylation increases binding affinity with F-Actin and induces axonal outgrowth; signal?force transduction in axon outgrowth +TP63 p63 DNA-binding; Transcription factor Q9H3D4 8626 3q28 human S51-p 28802100 TQTNEFLsPEVFQHI molecular association, regulation apoptosis, altered; transcription, altered; transcription, inhibited p300(DISRUPTS); PIN1(INDUCES) 23589370; 33548094 2 1 0 +Etv4 ETV4 DNA-binding P28322 18612 11 D|11 65.48 cM mouse K95-ac 26373300 HSPTTRIkKEPQSPR ETS_PEA3_N sumoylation transcription, induced 21543453 1 1 0 acetylated sites inhibits sumoylation reciprocally +HHEX HHEX DNA-binding; Transcription factor Q03014 3087 10q23.33 human S163-p 7430500 FETQKYLsPPERKRL Homeodomain molecular association, regulation transcription, induced DNA(INDUCES) 19324893 2 2 1 +TIAM1 TIAM1 GEF; GEF, Rac/Rho; Motility/polarity/chemotaxis; Oncoprotein Q13009 7074 21q22.11 human S329-p 23152631 DVNAGEGsEFADSGI protein degradation; molecular association, regulation BTRC(INDUCES) 25124033 1 1 2 +Kcnb1 Kv2.1 Channel, cation; Channel, ligand-gated; Channel, potassium; Membrane protein, integral; Membrane protein, multi-pass Q03717 16500 2 H3|2 87.22 cM mouse S804-p 473562 ESSPLPTsPKFLRPN apoptosis, induced 33333928 8 8 0 +FOXN3 FOXN3 DNA-binding; Transcription factor O00409 1112 14q31.3-q32.11 human S83-p 4930951 FGESVLRsVSPVQDL activity, induced; protein degradation; molecular association, regulation; ubiquitination signaling pathway regulation hnRNP U(DISRUPTS) 36794705 1 4 2 induces NFKB activity and signaling +Grin2a NMDAR2A Channel, ligand-gated; Membrane protein, integral; Membrane protein, multi-pass Q00959 24409 10q11 rat S1048-p 36747000 NRTHSLKsPRYLPEE NMDAR2_C activity, induced; receptor internalization, inhibited 25368549 1 0 0 increases NMDAR2A gating +Add2 ADD2 Cytoskeletal; Motility/polarity/chemotaxis Q05764 24171 4q34 rat S606-p 3147414 TPASPVQsPTRAGTK cytoskeletal reorganization 21606488 1 15 0 +SLC9A1 NHE1 Membrane protein, integral; Membrane protein, multi-pass; Motility/polarity/chemotaxis; Transporter; Transporter, SLC family P19634 6548 1p36.11 human S771-p 475074 MRSKETSsPGTDDVF activity, induced; protein stabilization; protein conformation 17209041; 23602949; 23678047; 25162926 7 4 0 mutant expression decreased, defect in activation by sustained acidosis +GRB14 GRB14 Adaptor/scaffold Q14449 2888 2q24.3 human S358-p 31834913 MHPYQGRsGCSSQSI molecular association, regulation; phosphorylation INSR(DISRUPTS) 24535599; 28130417 2 2 0 +PPARGC1A PGC-1 alpha Nuclear receptor co-regulator; Transcription, coactivator/corepressor Q9UBK2 10891 4p15.2 human K347-ac 63355302 QGNNSTKkGPEQSEL transcription, inhibited 28340340 0 1 0 +LCK Lck EC 2.7.10.2; KINASE; Kinase, protein; Oncoprotein; Protein kinase, TK; Protein kinase, tyrosine (non-receptor) P06239 3932 1p35.2 human Y505-p 447823 FTATEGQyQPQP___ molecular association, regulation; intracellular localization; enzymatic activity, inhibited; activity, inhibited; protein conformation; phosphorylation cell growth, altered Lck(INDUCES) 10962552; 1639064; 17897955; 20541955; 2141684; 23202272; 2503711; 3352600; 34321230; 35638332; 36078131 57 32 805 +EEF1A2 EEF1A2 Translation; Translation elongation Q05639 1917 20q13.33 human S205-p 27930804 GDNMLEPsPNMPWFK GTP_EFTU protein degradation; molecular association, regulation 23608534 2 0 0 increased association with polysomes and newly synthesized polypeptides (NSPs) +ELF3 ELF3 DNA-binding; Motility/polarity/chemotaxis; Transcription factor P78545 1999 1q32.1 human S207-p 482811 GTGASRSsHSSDSGG protein stabilization; ubiquitination; phosphorylation transcription, induced; cell growth, altered 17491012 1 0 0 +NOS3 eNOS Amino Acid Metabolism - arginine and proline; EC 1.14.13.39; Oxidoreductase P29474 4846 7q36.1 human S1177-p 447884 TSRIRTQsFSLQERQ intracellular localization; enzymatic activity, induced cell differentiation, altered; cell differentiation, induced; cell motility, altered; transcription, induced; cytoskeletal reorganization; signaling pathway regulation 10376603; 11319202; 11402048; 11425855; 11978735; 12446767; 12511559; 12791703; 15136572; 15319357; 15728587; 16043647; 16270749; 18622039; 18718903; 21757745; 23768697; 26132171; 31923467; 32653904; 33539947; 33836561; 34026871; 34078530; 34204249; 34499618; 35559724; 35747946; 35817960; 35884891; 37336943 217 18 7 +SOS1 SOS1 Adaptor/scaffold; GEF; GEF, Ras; Motility/polarity/chemotaxis Q07889 6654 2p22.1 human S1197-p 451317 KAYSPRYsISDRTSI molecular association, regulation GRB2(DISRUPTS) 8816480 1 2 0 +Nfatc1 NFAT2 DNA-binding; Transcription factor O88942 18018 18 E3|18 53.66 cM mouse K351-ac 1876152500 HAPSVALkVEPAGED activity, induced; molecular association, regulation transcription, induced DNA(INDUCES) 21498542 1 0 0 +H2BC3 H2B DNA-binding P33778 3018 6p22.2 human K15-ac 458957 PAPKKGSkKAITKAQ Histone molecular association, regulation cell cycle regulation; carcinogenesis, induced; chromatin organization, altered; transcription, induced; transcription, altered polybromo 1(INDUCES) 16283522; 19883641; 20368734 8 9 468 +RAPH1 RAPH1 Adaptor/scaffold; Motility/polarity/chemotaxis Q70E73 65059 2q33.2 human T1123-p 1883958004 VKKAPPPtRPKRNDS intracellular localization cell motility, induced VASP(DISRUPTS) 37632751 1 1 0 regulates MENA localization +EZH2 EZH2 EC 2.1.1.43; METHYLTRANSFERASE; Methyltransferase; Methyltransferase, protein lysine Q15910 2146 7q36.1 human T487-p 452848 APAEDVDtPPRKKKR protein degradation; protein stabilization; molecular association, regulation; ubiquitination carcinogenesis, induced; cell motility, induced; cell growth, induced; apoptosis, inhibited; transcription, induced FOXM1(INDUCES); SUZ12(DISRUPTS); RACK7(INDUCES); EED(DISRUPTS) 21659531; 25800736; 27716745; 33593912; 35960849 14 59 66 +Kcnma1 KCNMA1 Channel, potassium; Endoplasmic reticulum; Membrane protein, integral; Membrane protein, multi-pass Q08460 16531 14|14 A3 mouse S938-p 469989 HGMLRQPsITTGVNI activity, induced 11244090 4 2 0 Channel activation is dependent on S938 phosphorylation. +Src Src EC 2.7.10.2; KINASE; Kinase, protein; Oncoprotein; Protein kinase, TK; Protein kinase, tyrosine (non-receptor) P05480 20779 2 H1|2 78.35 cM mouse Y529-p 448235 FTSTEPQyQPGENL_ enzymatic activity, inhibited cell differentiation, inhibited; cell differentiation, altered 36906292; 7691597 153 24 968 +Nox4 NOX4 Cell cycle regulation; EC 1.6.3.-; Membrane protein, integral; Membrane protein, multi-pass; Nucleolus; Oxidoreductase Q9JHI8 50490 7|7 D3 mouse Y566-p 57848101 LSNRNNSyGTKFEYN molecular association, regulation; enzymatic activity, inhibited CYBA(DISRUPTS) 27525436 1 1 0 +Plxna1 PLXNA1 Membrane protein, integral; Motility/polarity/chemotaxis; Receptor, misc. P70206 18844 6|6 D1 mouse Y1815-p 6154597 KSWVERYyADIAKMP Plexin_cytopl cytoskeletal reorganization 25485759 1 0 1 necessary for the collapse response of commissural growth cones to SlitC +SF3B2 SF3B2 RNA processing; RNA splicing; RNA-binding; Spliceosome Q13435 10992 11q13.1 human R508-m2 35483240 PRHWCFKrKYLQGKR DUF382 molecular association, regulation RNA splicing, induced SMN(INDUCES) 25737013 1 1 0 +Slc2a2 GLUT2 Membrane protein, integral; Membrane protein, multi-pass; Transporter; Transporter, SLC family P12336 25351 2q24 rat T510-p 451347 SAPPRKAtVQMEFLG activity, inhibited 8626492 1 0 0 Phosphorylation reduces the initial rate of 3-O-methyl glucose uptake. +RCHY1 RCHY1 EC 6.3.2.-; EC 6.3.2.19; Nuclear receptor co-regulator; UBIQUITIN LIGASE; Ubiquitin conjugating system; Ubiquitin ligase Q96PM5 25898 4q21.1 human S211-p 27971904 VAQTPMPsEYQNMTV zinc_ribbon_6 ubiquitination; activity, inhibited transcription, inhibited 23603988 1 0 0 self-ubiquitination, may contribute to p53-inhibition of transcriptional elongation of HIV-LTR +IGF2BP2 IGF2BP2 RNA-binding; Translation Q9Y6M1 10644 3q27.2 human K139-ub 63726986 EAKIAMEkLSGHQFE RRM_1 protein degradation; molecular association, regulation autophagy, induced RNA(INDUCES) 31791342 1 2 0 +Atm ATM DNA repair, damage; EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, Ser/Thr (non-receptor); Protein kinase, atypical; Tumor suppressor Q62388 11920 9 A5.3|9 29.12 cM mouse S367-p 467198 DTRSVEIsQSYVTQR chromatin organization, altered 19047460 3 9 2 +CIITA CIITA DNA-binding; EC 2.7.11.1; KINASE; Protein kinase, Ser/Thr (non-receptor); Transcription, coactivator/corepressor P33076 4261 16p13.13 human S373-p 1295502 VQARLERsSSKSLER molecular association, regulation; activity, inhibited transcription, inhibited SIN3B(INDUCES) 17991736 1 0 0 +CHRM2 mAChR M2 GPCR, family 1; Membrane protein, integral; Membrane protein, multi-pass; Receptor, GPCR P08172 1129 7q33 human Y177-p 487429 TVEDGECyIQFFSNA 7tm_1 molecular association, regulation; protein conformation 17525129; 18723515 2 0 0 +Notch1 Notch 1 Membrane protein, integral; Motility/polarity/chemotaxis; Oncoprotein; Receptor, misc.; Transcription factor Q01705 18128 2 A3|2 18.91 cM mouse T2122-p 386186602 HGTALGGtPTLSPTL protein degradation; ubiquitination cell differentiation, inhibited 29140246 1 0 0 +ARHGAP31 CdGAP GAP; GAP, Rac/Rho Q2M1Z3 57514 3q13.32-q13.33 human S1106-p 4694057 KGKNRPSsLNLDPAI molecular association, regulation; intracellular localization transcription, induced; cytoskeletal reorganization; cell motility, inhibited 14-3-3 beta(INDUCES); 14-3-3 sigma(INDUCES) 29545927 1 4 0 14-3-3? inhibits the ability of CdGAP to repress the E-cadherin promoter and to induce cell migration; 14-3-3? sequesters CdGAP into the cytoplasm and inhibits its ability to induce cell rounding +Atg13 ATG13 Autophagy; Vesicle Q91YI1 51897 2|2 E1 mouse S258-p 53377100 CTTSFSTsPPSQLSS autophagy, inhibited 26801615 1 1 0 +CCKBR CCKBR GPCR, family 1; Membrane protein, integral; Membrane protein, multi-pass; Receptor, GPCR P32239 887 11p15.4 human T440-p 17825902 LSRLSYTtISTLGPG molecular association, regulation ARRB1(INDUCES) 21156802 1 0 0 +ARHGAP35 GRF-1 GAP; GAP, Rac/Rho; Motility/polarity/chemotaxis; Transcription factor; Tumor suppressor Q9NRY4 2909 19q13.32 human S1150-p 457041 LERGRKVsIVSKPVL RhoGAP_pG1_pG2 molecular association, regulation; activity, inhibited RND1(DISRUPTS) 19103606 1 40 55 +BIK BIK Apoptosis; Membrane protein, integral; Mitochondrial Q13323 638 22q13.2 human S35-p 448349 EVLGMTDsEEDLDPM bcl-2I13 molecular association, regulation apoptosis, induced Bcl-2(INDUCES); Bcl-xL(INDUCES) 11084041; 14633680 3 0 0 +DYNLT1 DYNLT1 Microtubule-binding; Motility/polarity/chemotaxis; Motor P63171 282380 cow T94-p 456225 SSTDGSCtVRWENKT Tctex-1 molecular association, regulation endocytosis, induced Arp3(DISRUPTS) 28607034 7 0 0 Cdc42 activation, ciliary resorption +CEBPB C/EBP-beta DNA-binding; Motility/polarity/chemotaxis; Transcription factor P17676 1051 20q13.13 human Y78-p 9397201 RAIDFSPyLEPLGAP protein stabilization cell cycle regulation; apoptosis, altered; transcription, induced 19563810 1 0 0 +TEX12 TEX12 Q9BXU0 56158 11q23.1 human Y48-p 23152088 SEISGLFyKDEALEK TEX12 cell cycle regulation; carcinogenesis, induced; chromatin organization, altered; cell growth, induced 34880391 1 0 1 +Trpc6 TRPC6 Channel, cation; Membrane protein, integral; Membrane protein, multi-pass Q61143 22068 9 A1|9 2.46 cM mouse S28-p 22280200 AGTRRNEsQDYLLMD activity, inhibited 22001259 1 0 0 +PLEKHG6 PLEKHG6 GEF; GEF, Rac/Rho Q3KR16 55200 12p13.31 human T574-p 4145508 HLVVTEDtDEDAPLV activity, induced; intracellular localization 18694934 2 0 0 enhances PLEKHG6 activity towards RhoA +SKA3 SKA3 Cell cycle regulation Q8IX90 221150 13q12.11 human T203-p 1869388600 SLVKVLKtPKCALKM molecular association, regulation; intracellular localization cell cycle regulation; chromatin organization, altered; cytoskeletal reorganization HEC1(INDUCES) 32491969 1 1 0 +MAP2K6 MKK6 EC 2.7.12.2; KINASE; Kinase, protein; Protein kinase, STE; Protein kinase, dual-specificity (non-receptor) P52564 5608 17q24.3 human S207-p 448194 ISGYLVDsVAKTIDA Pkinase enzymatic activity, induced; phosphorylation transcription, induced; signaling pathway regulation 11460167; 21878628; 8622669 13 20 65 +ATF1 ATF-1 Transcription factor P18846 466 12q13.12 human T184-p 31858260 QTYQIRTtPSATSLP protein stabilization; molecular association, regulation; enzymatic activity, induced carcinogenesis, induced; cell motility, induced; cell growth, induced; transcription, induced PIN1(INDUCES) DNA(INDUCES) 28032861; 35397606 2 0 0 +PRKN PARK2 EC 6.3.2.-; EC 6.3.2.19; Ligase; Translation; Translation regulation; UBIQUITIN LIGASE; Ubiquitin conjugating system; Ubiquitin ligase O60260 5071 6q26 human S109-p 1872827404 LTRVDLSsSVLPGDS ubiquitination; intracellular localization; phosphorylation; enzymatic activity, induced autophagy, induced 33827825 1 1 0 induces phosphorylation at S65 and ubiquitination of substrates +ETS1 Ets-1 DNA-binding; Motility/polarity/chemotaxis; Oncoprotein; Transcription factor P14921 2113 11q24.3 human S257-p 449319 DSFESIEsYDSCDRL Ets1_N_flank molecular association, regulation; activity, inhibited transcription, inhibited DNA(DISRUPTS) 12475968 4 0 1 +HMGN1 HMGN1 DNA-binding; Nuclear receptor co-regulator P05114 3150 21q22.2 human K38-ac 458847 KVEAKPKkAAAKDKS HMG14_17 molecular association, regulation DNA(DISRUPTS) 10753971 1 0 0 +AICDA AID EC 3.5.4.38; Hydrolase Q9GZX7 57379 12p13.31 human T27-p 471423 WAKGRREtYLCYVVK APOBEC2 enzymatic activity, inhibited; enzymatic activity, induced 16387847; 21659520 5 2 0 class switch recombinaton +CLCN3 CLCN3 Channel, chloride; Membrane protein, integral; Membrane protein, multi-pass; Transporter; Transporter, ion channel; Vesicle P51790 1182 4q33 human S109-p 451427 ERHRRINsKKKESAW activity, induced; activity, inhibited neural plasticity 14754994; 23165767 2 0 0 +TJP1 ZO1 Adaptor/scaffold; Motility/polarity/chemotaxis Q07157 7082 15q13.1 human S168-p 470469 ASRERSLsPRSDRRS molecular association, regulation; intracellular localization ITGA5(INDUCES) 19567915 2 16 11 +RHO Rhodopsin GPCR, family 1; Membrane protein, integral; Membrane protein, multi-pass; Receptor, GPCR P08100 6010 3q22.1 human T336-p 3091410 GDDEASAtVSKTETS molecular association, regulation ARRB1(INDUCES) 28753425 2 3 0 +Tgm2 TGM2 EC 2.3.2.13; KINASE; Transferase P21981 21817 2 H1|2 78.72 cM mouse S216-p 467223 RDCSRRSsPIYVGRV activity, induced; enzymatic activity, induced cell cycle regulation; cell motility, induced; cell growth, induced; transcription, inhibited; signaling pathway regulation 22759359 3 4 2 phosphorylation of TGM2 at S216 causes NF-kB activation and downregulation of PTEN transcription, and consequently Akt activation. +BARD1 BARD1 EC 6.3.2.-; EC 6.3.2.19; Ligase; UBIQUITIN LIGASE; Ubiquitin conjugating system; Ubiquitin ligase Q99728 580 2q35 human T299-p 455768 KSRNEVVtPEKVCKN cell cycle regulation 15855157 2 11 24 resistance to genotoxic stress (mitomycin C) +Prm1 PRM1 Cancer Testis Antigen (CTA); DNA-binding P02319 19118 16 A1|16 5.87 cM mouse S43-p 36699681 RCCRRRRsYTIRCKK Protamine_P1 molecular association, regulation; intracellular localization chromatin organization, altered NPM2(INDUCES); HIRA(INDUCES) DNA(DISRUPTS) 32169215 1 1 0 induces protamine-to-histone exchange on DNA +RECQL5 RECQL5 DNA repair, damage; EC 3.6.4.12; Helicase O94762 9400 17q25.1 human S727-p 4767154 SAHYGGPsPEKKAKS RecQ5 cell cycle regulation 28575661 1 23 0 +AURKB AurB EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, Other; Protein kinase, Ser/Thr (non-receptor) Q96GD4 9212 17p13.1 human T232-p 450325 APSLRRKtMCGTLDY Pkinase intracellular localization; phosphorylation; enzymatic activity, induced cell cycle regulation; carcinogenesis, induced; cytoskeletal reorganization INCENP(INDUCES) 14722118; 19203582; 20171103; 24344188; 26829474; 27557660; 28004745; 31819079; 35301407 34 17 90 +Blnk BLNK Adaptor/scaffold Q9QUN3 17060 19 C3|19 34.26 cM mouse K37-ub 23303203 GGIMDKIkKLKVKGP molecular association, regulation; ubiquitination 14-3-3 beta(INDUCES) 22334673 1 0 0 Thr-152 phosphorylation induces BLNK ubiquitination at K37, K38, K42. +GATAD2A GATAD2A Transcription factor Q86YP4 54815 19p13.11 human K487-sm 3755611 GTAPAQAkAEPTAAP transcription, inhibited 16738318 1 1 0 +AR AR DNA-binding; Nuclear receptor; Transcription factor P10275 367 Xq12 human S792-p 448415 CVRMRHLsQEFGWLQ Hormone_recep intracellular localization chromatin organization, altered; apoptosis, inhibited; transcription, altered 17470458; 23945560 5 0 0 low phosphorylation associated with increased androgen receptor gene amplification; Mutation reduces transport to the nucleus. S213A and S791A mutations reduce binding to androgen. +EIF2S1 eIF2-alpha RNA-binding; Translation; Translation initiation P05198 1965 14q23.3 human S49-p 450210 IEGMILLsELSRRRI S1 molecular association, regulation translation, altered eIF2-beta(INDUCES); PERK(INDUCES) 16288713 4 1 0 +RBL2 Rb-like 2 Transcription, coactivator/corepressor; Tumor suppressor Q08999 5934 16q12.2 human S1080-p 449741 IFYYFSNsPSKRLRE molecular association, regulation; intracellular localization cell cycle regulation KPNA1(DISRUPTS); E2F4(DISRUPTS) 11157749; 12006580; 20857408 5 10 0 +PPARA PPAR-alpha DNA-binding; Nuclear receptor; UBIQUITIN LIGASE Q07869 5465 22q13.31 human S21-p 1789803 LEAGDLEsPLSEEFL activity, induced; protein stabilization signaling pathway regulation; transcription, inhibited 18079279; 21224484; 21525007 4 0 0 increases SR-BI stability, increases cholesterol efflux. +Nkx3-2 NKX3-2 Cell development/differentiation; DNA-binding; Transcription factor P97503 12020 5 B3|5 22.58 cM mouse K262-ub 1593379701 QNRRYKTkRRQMAAD Homeodomain molecular association, regulation apoptosis, inhibited IKKG(INDUCES) 21606193 1 1 0 ubiquitination-dependent interaction with IKKG (aka NEMO) promotes formation of the complex NKX3.2-IKKG(NEMO)-IKKB +Ripk1 RIPK1 EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, Ser/Thr (non-receptor); Protein kinase, TKL Q60855 19766 13 A3.3|13 14.01 cM mouse S336-p 209632700 LPPSRSNsEQPGSLH molecular association, regulation; enzymatic activity, induced apoptosis, inhibited RIPK3(INDUCES) 28842570; 28920952; 28920954 4 2 0 +CRK CRK Adaptor/scaffold; Motility/polarity/chemotaxis; Oncoprotein Q04929 417553 chicken Y222-p 447951 GGPEPGPyAQPSINT molecular association, regulation; protein conformation cell differentiation, altered; cell adhesion, altered PXN(DISRUPTS); Abl(DISRUPTS); Abl iso2(DISRUPTS) 10825157; 17289588 25 14 1168 +CKMT2 CKMT2 Amino Acid Metabolism - arginine and proline; EC 2.7.3.2; Kinase, other; Mitochondrial P17540 1160 5q14.1 human Y159-p 1914421 QGQFDEHyVLSSRVR enzymatic activity, induced transcription, induced; signaling pathway regulation 34095014 1 2 56 induces PGC-1a/estrogen-related receptor-a pathway +RBL2 Rb-like 2 Transcription, coactivator/corepressor; Tumor suppressor Q08999 5934 16q12.2 human S948-p 449731 SGSSDSRsHQNSPTE RB_B molecular association, regulation cell cycle regulation E2F4(DISRUPTS) 11157749 2 12 0 +MUC1 MUC1 Actin-binding; Cell adhesion; Membrane protein, integral; Motility/polarity/chemotaxis; Nuclear receptor co-regulator; Tumor suppressor P15941 4582 1q22 human T1224-p 455682 RYVPPSStDRSPYEK molecular association, regulation cell growth, altered 11877440 2 1 3 +Ulk1 ULK1 Autophagy; EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, Other; Protein kinase, Ser/Thr (non-receptor) O70405 22241 5|5 F mouse S317-p 35495300 SHLASPPsLGEMPQL autophagy, induced 21258367 20 1 0 +BRCA1 BRCA1 EC 6.3.2.-; Nuclear receptor co-regulator; Transcription, coactivator/corepressor; Tumor suppressor; UBIQUITIN LIGASE; Ubiquitin conjugating system; Ubiquitin ligase P38398 672 17q21.31 human K119-sm 11539302 NNSPEHLkDEVSIIQ molecular association, regulation; enzymatic activity, induced DNA repair, induced 20016594 1 0 0 +Ppm1j PPM1J EC 3.1.3.16; PHOSPHATASE; Protein phosphatase, Ser/Thr (non-receptor) Q149T7 71887 3|3 F2.2 mouse S92-p 2846507 HAGRAVQsPPDTGRR enzymatic activity, inhibited; protein conformation 18553930 1 0 0 +CTLA4 CTLA-4 Immunoglobulin superfamily; Membrane protein, integral P16410 1493 2q33.2 human Y201-p 450897 SPLTTGVyVKMPPTE molecular association, regulation; intracellular localization SHP-1(INDUCES) 10604992; 11970985 5 0 1 +CDC34 CDC34 EC 6.3.2.19; Ligase; UBIQUITIN LIGASE; Ubiquitin conjugating system; Ubiquitin ligase P49427 997 19p13.3 human S203-p 448687 APAPDEGsDLFYDDY intracellular localization 11546811 2 0 0 +ID3 ID3 DNA-binding; Transcription, coactivator/corepressor Q02535 3399 1p36.12 human Y11-p 15411043 LSPVRGCyEAVCCLS protein stabilization 25090023 1 1 10 regulates vascular EC survival and growth of microvascular lesions +Npy1r NPY1R GPCR, family 1; Membrane protein, integral; Membrane protein, multi-pass; Receptor, GPCR P21555 29358 16p14 rat S352-p 455138 DYETIAMsTMHTDVS receptor desensitization, altered; receptor internalization, altered 15576634 1 0 0 may be an artifact of the truncation mutants +DEK DEK DNA replication; DNA-binding; Histone-binding; Oncoprotein; RNA splicing P35659 7913 6p22.3 human S19-p 465615 GTPTQPAsEKEPEMP molecular association, regulation RNA splicing, altered U2AF1(INDUCES) 16809543 2 8 0 +Kcna2 Kv1.2 Channel, potassium; Membrane protein, integral; Membrane protein, multi-pass P63142 25468 2q34 rat S449-p 1818102 PDLKKSRsASTISKS intracellular localization; phosphorylation 18056633 2 3 1 reduces phosphorylation on S440/S441 +EIF6 EIF6 Nucleolus; Translation; Translation initiation P56537 3692 20q11.22 human T231-p 31863506 LNEAQPStIATSMRD intracellular localization translation, altered 32703900 1 2 0 +PRKDC DNAPK DNA repair, damage; EC 2.7.11.1; KINASE; Kinase, protein; Nucleolus; Protein kinase, Ser/Thr (non-receptor); Protein kinase, atypical P78527 5591 8q11.21 human S2675-p 3193637 VDHTSPSsDSLLFAH DNAPKcs_CC5 DNA repair, inhibited 24687855 1 2 0 cell survival inhibited +HOXB13 HOXB13 DNA-binding; Transcription factor Q92826 10481 17q21.32 human T41-p 1883583908 TSHPAAPtLMPAVNY protein degradation; molecular association, regulation; ubiquitination; intracellular localization carcinogenesis, induced; cell growth, induced; transcription, altered SKP2(INDUCES) 37409967 1 0 0 induces nuclear translocation of NFKB +MACC1 MACC1 Q6ZN28 346389 7p21.1 human Y673-p 1874020218 VLADVLGySHLSLED phosphorylation carcinogenesis, induced; cell motility, induced; cell growth, induced; transcription, induced 34247190 1 1 0 +PTK2 FAK EC 2.7.10.2; KINASE; Kinase, protein; Protein kinase, TK; Protein kinase, tyrosine (non-receptor) Q05397 5747 8q24.3 human Y861-p 447965 PIGNQHIyQPVGKPD activity, induced; molecular association, regulation; intracellular localization; activity, inhibited; enzymatic activity, induced; phosphorylation carcinogenesis, induced; apoptosis, altered; cell growth, induced; cell motility, induced; cytoskeletal reorganization; cell adhesion, altered; cell growth, altered P130Cas(INDUCES); ITGB5(INDUCES) 11839732; 11927607; 12084011; 15123632; 15735019; 16461767; 18794113; 21852560; 21994943; 25868388; 34169835; 34335982; 35257717; 35999654 75 21 307 +DCBLD2 DCBLD2 Cell adhesion; Membrane protein, integral Q96PD2 131566 3q12.1|3 human Y732-p 455063 CSSAQAQyDTPKAGK molecular association, regulation CRKL(INDUCES) 23770091 1 14 193 +Tbc1d4 AS160 GAP; GAP, Rab Q8BYJ6 210789 14|14 E2.3 mouse T649-p 455921 QFRRRAHtFSHPPSS molecular association, regulation; intracellular localization; phosphorylation endocytosis, induced; signaling pathway regulation 14-3-3 beta(INDUCES); IRAP(DISRUPTS) 19897488; 19923418; 20332342; 21195350; 33872597 45 21 134 Rictor/mTORC2 signaling in energy metabolism in fat cells; regulates GLUT4 trafficking, induces glucose uptake +PTPN12 PTP-PEST EC 3.1.3.48; Motility/polarity/chemotaxis; PHOSPHATASE; Protein phosphatase, tyrosine (non-receptor) Q05209 5782 7q11.23 human S39-p 451311 FMRLRRLsTKYRTEK molecular association, regulation; enzymatic activity, inhibited; activity, inhibited HER2(DISRUPTS) 28842430; 7520867 5 0 15 +Oprl1 KOR-3 GPCR, family 1; Membrane protein, integral; Membrane protein, multi-pass; Receptor, GPCR P35370 29256 3q43 rat S334-p 456132 FRKFCCAsSLHREMQ activity, induced; receptor desensitization, altered 16019191 1 0 0 +AURKB AurB EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, Other; Protein kinase, Ser/Thr (non-receptor) Q9N0X0 396955 pig T232-p 450325 APSLRRKtMCGTLDY Pkinase enzymatic activity, induced 16452462 34 17 90 +TP63 p63 DNA-binding; Transcription factor Q9H3D4 8626 3q28 human T46-p 912008301 TMSQSTQtNEFLSPE transcription, induced 29559659 1 0 0 Induction of LCE1C and ANXA8L1 transcription +ENG ENG Membrane protein, integral; Motility/polarity/chemotaxis; Receptor, misc. P17813 2022 9q34.11 human S635-p 465619 AVAAPASsESSSTNH phosphorylation 16785228 1 1 0 required for threonine phosphorylation of ENG +Epas1 HIF2A DNA-binding; Transcription factor P97481 13819 17|17 E4 mouse S834-p 2085802 ASRLLGPsFEPYLLP transcription, inhibited 11983697 1 0 0 +CARD9 CARD9 Adaptor/scaffold Q9H257 64170 9q34.3 human T531-p 1206001 NTTGSDNtDTEGS__ activity, inhibited 17936701 1 1 0 impairs ability of CARD9 to activate NF-kB +Bnip3 BNIP3 Membrane protein, integral; Mitochondrial O55003 12176 7|7 F4 mouse T181-p 41388500 IYIGRRLtTSTSTF_ BNIP3 molecular association, regulation; intracellular localization 14-3-3 beta(INDUCES) 34824192 2 2 0 +GPBAR1 GPBAR1 GPCR, family 1; Membrane protein, integral; Membrane protein, multi-pass; Receptor, GPCR Q8TDU6 151306 2q35 human S321-p 1877729202 SIAYHPSsQSSVDLD molecular association, regulation cell growth, induced; apoptosis, inhibited ARRB1(INDUCES) 35858343 0 1 0 +Ywhag 14-3-3 gamma Adaptor/scaffold P61982 22628 5|5 G2 mouse K50-ac 474722 NLLSVAYkNVVGARR 14-3-3 molecular association, regulation STAR(INDUCES) 25086053 1 5 15 +ERCC6 ERCC6 DNA repair, damage; EC 3.6.1.-; EC 3.6.4.-; Helicase; Transcription regulation Q03468 2074 10q11.23 human T1031-p 1875831800 GTGSDVQtPKCHLKR molecular association, regulation; intracellular localization DNA repair, altered MRE11A(INDUCES) 34871413 1 0 0 +Cited1 CITED1 Nuclear receptor co-regulator P97769 12705 X D|X 45.25 cM mouse S69-p 27937111 TSSSGSTsPIGSPTA CITED intracellular localization cell differentiation, induced 23529225 1 0 0 S63/64/65/67/69/73/79/80/84A mutation in CITED1 inhibits its translocation into the nucleus and osteoblasts differentiation +MAPK1 ERK2 EC 2.7.11.24; KINASE; Kinase, protein; Protein kinase, CMGC; Protein kinase, Ser/Thr (non-receptor) P28482 5594 22q11.22 human T185-p 447593 HDHTGFLtEYVATRW Pkinase activity, induced; protein degradation; molecular association, regulation; intracellular localization; protein conformation; phosphorylation; enzymatic activity, induced cell cycle regulation; carcinogenesis, induced; apoptosis, altered; cell motility, induced; transcription, induced; signaling pathway regulation; cell growth, induced; cell differentiation, induced; cell motility, altered; cytoskeletal reorganization; transcription, inhibited; cell growth, altered G-beta 1(INDUCES); TACE(INDUCES); leupaxin(NOT_REPORTED); GSK3B(INDUCES); p90RSK(INDUCES); KSR(INDUCES); NFkB-p100(DISRUPTS) 10597231; 10925301; 11352917; 12609989; 12808105; 15004239; 16149052; 16397900; 17562849; 17667937; 17685427; 18042541; 18045996; 18519681; 18658095; 18775330; 19060905; 19088846; 19106095; 19144315; 20122898; 20231899; 20868520; 21478863; 21530327; 21561860; 21685939; 21726627; 21730054; 21842857; 21893193; 21917714; 21980390; 22385658; 23644655; 25538243; 25730857; 26079947; 26686085; 27323830; 28574827; 30987999; 31722981; 31736979; 31964804; 34017102; 34226680; 36289618 1139 120 2416 autoamplifcation of NFAT-c1, which promotes osteoclast differentiation, suppressed by MLN4924 +HIPK2 HIPK2 EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, CMGC; Protein kinase, Ser/Thr (non-receptor) Q9H2X6 28996 7q34 human T566-p 27732205 DTVNQSKtPFITHVA enzymatic activity, induced cell growth, inhibited 28060750 1 2 0 IPK2-T566P mutant showed a very mild reduction of kinase activity +Aida AIDA Cell development/differentiation Q8C4Q6 108909 1|1 H5 mouse S161-p 15495718 TLLPRLPsEPGMTLL Aida_C2 molecular association, regulation; intracellular localization UCP1(INDUCES) 33664495 1 11 0 activates thermogenesis +NFATC3 NFAT4 DNA-binding; Transcription factor Q12968 4775 16q22.1 human S165-p 448858 RESSLSPsPASSISS intracellular localization transcription, inhibited 9374467 2 2 0 +BECN1 beclin 1 Adaptor/scaffold; Autophagy; Membrane protein, peripheral Q14457 8678 17q21.31 human S234-p 27156802 AQYQREYsEFKRQQL APG6_N cell cycle regulation; carcinogenesis, induced; autophagy, inhibited 34077419 3 0 0 +HGS Hrs Adaptor/scaffold; Motility/polarity/chemotaxis O14964 9146 17q25.3 human Y329-p 450191 IDPELARyLNRNYWE intracellular localization; receptor recycling, altered; phosphorylation 12953068; 17101784 2 10 170 Hrs phosphorylation mutant Y329,334F is unable to degrade ubiquinated EGFR. ; Cbl expression alters Hrs phosphorylation and fractionation in membrane and cyosokic fractions. +RBL2 Rb-like 2 Transcription, coactivator/corepressor; Tumor suppressor Q08999 5934 16q12.2 human S966-p 449734 DRTSRDSsPVMRSSS RB_B molecular association, regulation cell cycle regulation E2F4(DISRUPTS) 11157749 2 3 1 +KIF2B KIF2B Microtubule-binding; Motor Q8N4N8 84643 17q22 human S201-p 25247534 YRRHLDSsKISVLEP intracellular localization cell cycle regulation 22535524 1 1 0 +Actr2 ARP2 Actin-binding; Cytoskeletal; Motility/polarity/chemotaxis P61161 66713 11 A3.1|11 12.88 cM mouse T238-p 36440501 QKLALETtVLVESYT Actin intracellular localization 28947541 4 0 0 colocalization with F-actin (decreased in aging macrophages) +H3C1 H3 DNA-binding P68431 8350 6p22.2 human K56-ac 3804954 REIRRYQkSTELLIR Histone molecular association, regulation; intracellular localization cell cycle regulation; cell differentiation, inhibited; carcinogenesis, induced; apoptosis, induced; transcription, induced; transcription, altered; cell differentiation, altered; DNA repair, induced; chromatin organization, altered; DNA repair, altered; cell growth, altered SMAD4(INDUCES); SMAD2(INDUCES); SMAD3(INDUCES) DNA(INDUCES); DNA(DISRUPTS) 19250903; 19270680; 19407812; 19411844; 19625767; 19818718; 20100606; 20347425; 20462404; 20520775; 20587414; 23287868; 26255936; 31071955; 31815277 33 14 2 Hdac1/2 knock-out thymocytes: importnant for T-cell development and genomic stability; increased upon successful completion of DNA repair ; HDACi panobinostat induced apoptosis in K562 and K562-IR cells +RAD52 RAD52 DNA repair, damage P43351 5893 12p13.33 human Y104-p 449061 DLNNGKFyVGVCAFV Rad52_Rad22 activity, induced; molecular association, regulation; intracellular localization DNA repair, induced DNA(INDUCES) 12379650; 21804533; 23836560 4 0 0 enhances ssDNA annealing activity by attenuating dsDNA binding.; single-strand annealing but not homologous recombination repair +PBK PBK Cancer Testis Antigen (CTA); EC 2.7.12.2; KINASE; Kinase, protein; Protein kinase, Other; Protein kinase, Ser/Thr (non-receptor); Protein kinase, dual-specificity (non-receptor) Q96KB5 55872 8p21.1 human S32-p 471715 PTINIPAsPFMQKLG carcinogenesis, induced; cell growth, induced; apoptosis, inhibited 35546143 1 16 33 +Hmga1 HMGA1 DNA-binding Q8K585 117062 20p12 rat S44-p 479856 PGTALVGsQKEPSEV molecular association, regulation DNA(DISRUPTS) 10617144 2 43 17 +CDC25B CDC25B iso2 EC 3.1.3.48; Motility/polarity/chemotaxis; Nuclear receptor co-regulator; PHOSPHATASE; Protein phosphatase, dual-specificity P30305-2 994 20p13 human S101-p 9819902 DAGLCMDsPSPMDPH M-inducer_phosp protein degradation; ubiquitination cell cycle regulation 19638579; 21807946 2 0 0 +TFEB TFEB DNA-binding; Transcription factor P19484 7942 6p21.1 human S114-p 3181613 HISPAQGsPKPPPAA MITF_TFEB_C_3_N activity, induced; intracellular localization transcription, inhibited; cell growth, altered 29945972 2 35 0 +IGF1R IGF1R EC 2.7.10.1; KINASE; Kinase, protein; Membrane protein, integral; Protein kinase, TK; Protein kinase, tyrosine (receptor) P08069 3480 15q26.3 human Y1165-p 448387 RDIYETDyYRKGGKG PK_Tyr_Ser-Thr molecular association, regulation; protein conformation; enzymatic activity, induced carcinogenesis, induced; autophagy, induced; cell motility, induced; apoptosis, inhibited Cbl-c(INDUCES) 11591350; 16793764; 34921013; 36543142 20 38 707 +LONP1 PRSS15 DNA-binding; EC 3.4.21.-; Mitochondrial; Protease; RNA-binding P36776 9361 19p13.3 human S173-p 1869121004 VFLKRDDsNESDVVE LON_substr_bdg enzymatic activity, induced carcinogenesis, inhibited 31406245 1 1 0 regulation of mitochondrial bioenergetics +CPNE1 CPNE1 Lipid-binding Q99829 8904 20q11.22 human K157-ub 12313481 DKKDFLGkSDPFLEF C2 protein degradation carcinogenesis, induced; cell growth, induced 34743202 1 5 26 +Nos1 nNOS Amino Acid Metabolism - arginine and proline; EC 1.14.13.39; Oxidoreductase P29476 24598 12q16 rat K989-ac 2459100 QGLSNVHkKRVSAAR FAD_binding_1 activity, induced 18415985 1 1 0 +DLG1 DLG1 Adaptor/scaffold; Motility/polarity/chemotaxis Q12959 1739 3q29 human S158-p 2024309 FVSHSHIsPIKPTEA MAGUK_N_PEST protein degradation; protein stabilization; molecular association, regulation; ubiquitination; intracellular localization cytoskeletal reorganization GKAP1(DISRUPTS) 15729360; 19066288; 19307009 4 16 0 +GAD1 GAD67 Amino Acid Metabolism - alanine, aspartate and glutamate; Carbohydrate Metabolism - butanoate; EC 4.1.1.15; Lyase; Mitochondrial; Other Amino Acids Metabolism - beta-alanine; Other Amino Acids Metabolism - taurine and hypotaurine Q99259 2571 2q31.1 human T91-p 451699 RDARFRRtETDFSNL activity, inhibited 15147202 1 1 0 +Khdrbs1 KHDRBS1 RNA-binding Q60749 20218 4|4 D2.2 mouse Y440-p 456716 GAYREHPyGRY____ intracellular localization 16179349 1 0 26 +Rcan1 RCAN1 Inhibitor Q9JHG6 54720 16 C4|16 53.6 cM mouse S146-p 25687504 AQTLHIGsSHLAPPN Calcipressin molecular association, regulation PPP3CA(DISRUPTS) 22864830 3 2 0 +ETS1 Ets-1 DNA-binding; Motility/polarity/chemotaxis; Oncoprotein; Transcription factor P14921 2113 11q24.3 human S269-p 1873117008 DRLTQSWsSQSSFNS Ets1_N_flank activity, induced; protein stabilization; molecular association, regulation carcinogenesis, induced; cell motility, induced; transcription, induced; signaling pathway regulation p300(INDUCES) DNA(INDUCES) 34023818 1 1 0 transcriptional activation of matrix metalloproteinase (MMP)-9; inhibits ubiquitination, regulates GSK3?/ETS1/MMP-9 signaling +NDC80 HEC1 Cell cycle regulation O14777 10403 18p11.32 human S50-p 12667684 LSINKPTsERKVSLF cytoskeletal reorganization 35878017 1 5 0 +TNS3 tensin 3 Adaptor/scaffold; Motility/polarity/chemotaxis Q68CZ2 64759 7p12.3 human Y1206-p 9824601 SHSFRGAyGLAMKVA SH2 molecular association, regulation cell motility, altered; cell growth, altered P130Cas(INDUCES); KHDRBS1(INDUCES); FAK(INDUCES) 19732724 1 0 0 contributes to tumorigenesis and metastasis +TP63 p63 DNA-binding; Transcription factor Q9H3D4 8626 3q28 human S479-p 4668107 MNKLPSVsQLINPQQ activity, induced; protein degradation; molecular association, regulation cell growth, inhibited; apoptosis, induced; transcription, altered NFYA(INDUCES) DNA(INDUCES) 18769144; 20023394 2 1 0 +Rb1 Rb Nuclear receptor co-regulator; Oncoprotein; Transcription, coactivator/corepressor; Tumor suppressor P33568 24708 15q11 rat T818-p 447984 LPTPTKMtPRSRILV Rb_C cell cycle regulation 20484410 20 37 56 +Stmn1 STMN1 Cytoskeletal P54227 16765 4 D3|4 66.76 cM mouse S38-p 448556 SVPDFPLsPPKKKDL Stathmin protein stabilization; phosphorylation carcinogenesis, induced; cell motility, induced; cell growth, induced; apoptosis, induced; signaling pathway regulation 20630875; 21646391; 36484700 49 114 166 +DYRK1B DYRK1B EC 2.7.12.1; KINASE; Kinase, protein; Protein kinase, CMGC; Protein kinase, dual-specificity (non-receptor) Q9Y463 9149 19q13.2 human S421-p 50269512 YEPAARIsPLGALQH Pkinase enzymatic activity, induced 26346493 1 3 0 +FOXO1 FOXO1A DNA-binding; Nuclear receptor co-regulator; Oncoprotein; Transcription factor Q12778 2308 13q14.11 human S319-p 449113 TFRPRTSsNASTISG activity, induced; molecular association, regulation; intracellular localization cell differentiation, inhibited; apoptosis, altered; cell growth, induced; signaling pathway regulation; transcription, altered; transcription, inhibited IQGAP1(INDUCES) 12228231; 14664696; 15934941; 16670091; 18794113; 20061393; 21697492; 23995784; 28279977; 34948236; 35966593 29 5 27 +CTNNAL1 CTNNAL1 Adaptor/scaffold Q9UBT7 8727 9q31.3 human Y536-p 479128 RRGEKYGyLSLPKPM intracellular localization 17952117 1 1 21 mutantsand wild-type were localized throughout the cytoplasm, and partially associated with the plasma membrane +Sphk1 SPHK1 ACETYLTRANSFERASE; Acetyltransferase; EC 2.3.1.-; EC 2.7.1.91; Kinase, lipid; Lipid Metabolism - sphingolipid Q8CI15 20698 11|11 E2 mouse S373-p 51621300 DAPSGRDsRRGPPPE enzymatic activity, inhibited 26642194 1 0 0 +RPS3 RPS3 Apoptosis; EC 4.2.99.18; RNA-binding; Ribosomal; Translation P23396 6188 11q13.4 human R67-m2 9184303 GEKGRRIrELTAVVQ KH_2 intracellular localization 19460357 1 0 0 regulates ribosome assembly +Stmn2 STMN2 Cytoskeletal P21818 84510 2q23 rat S73-p 450173 EAPRTLAsPKKKDLS Stathmin cytoskeletal reorganization 9525956 9 1 0 +YKT6 YKT6 EC 2.3.1.-; Endoplasmic reticulum; Membrane protein, integral; Transferase; Vesicle O15498 10652 7p13 human S174-p 27456090 LDDLVSKsEVLGTQS Synaptobrevin molecular association, regulation; intracellular localization; protein conformation cell growth, inhibited; autophagy, inhibited GOSR2(DISRUPTS); SCFD1(DISRUPTS); STX17(DISRUPTS); SNAP29(DISRUPTS) 33723042 2 6 0 +DGCR8 DGCR8 Nucleolus; RNA processing; RNA-binding Q8WYQ5 54487 22q11.21 human S153-p 34490414 AECGLLLsPVSGDVH DNA repair, inhibited 28380355 1 1 0 +DDX5 DDX5 EC 3.6.4.13; Helicase; Nuclear receptor co-regulator; Nucleolus; RNA splicing; RNA-binding; Spliceosome P17844 1655 17q23.3 human Y593-p 470084 NGMNQQAyAYPATAA molecular association, regulation; intracellular localization cell growth, induced; apoptosis, inhibited; transcription, induced; cytoskeletal reorganization CTNNB1(INDUCES) 17018282; 17384675; 17412694 4 2 1 transcription of cyclin D1 and c-Myc genes +IGFBP3 IGFBP3 Cell development/differentiation; Secreted; Secreted, signal peptide P17936 3486 7p12.3 human S156-p 37046603 VESPSVSsTHRVSDP apoptosis, inhibited 25525174 1 0 0 involved in pioglitazone-induced regulation of IGFBP-3 +AKT1S1 PRAS40 Apoptosis Q96B36 84335 19q13.33 human S202-p 454571 EKRTEARsSDEENGP PRAS molecular association, regulation cell growth, induced; autophagy, inhibited 14-3-3 beta(INDUCES); Raptor(DISRUPTS) 26876154 2 45 109 activates mTORC1 +CDK2 CDK2 Cell cycle regulation; EC 2.7.11.22; KINASE; Kinase, protein; Protein kinase, CMGC; Protein kinase, Ser/Thr (non-receptor) P24941 1017 12q13.2 human T39-p 2712201 LKKIRLDtETEGVPS Pkinase intracellular localization cell cycle regulation; apoptosis, induced 18354084 1 1 0 contributes to the cell death induced by methotrexate and docetaxel +Slc1a6 SLC1A6 Membrane protein, integral; Membrane protein, multi-pass; Transporter; Transporter, SLC family O35921 84012 7q11 rat T40-p 480172 RTRLRLQtMTREHVR intracellular localization 17442044 1 0 0 +Myog myogenin DNA-binding; Transcription factor P12979 17928 1 E4|1 58.18 cM mouse T57-p 1880114102 LEEKGLGtPEHCPGQ protein degradation; molecular association, regulation; ubiquitination transcription, inhibited FBXO32(INDUCES) 36259412 1 0 0 +CDC42 CDC42 iso1 G protein; G protein, monomeric; G protein, monomeric, Rho; Motility/polarity/chemotaxis P60953-1 998 1p36.12 human Y64-p 450272 DTAGQEDyDRLRPLS Ras activity, induced; molecular association, regulation cell growth, altered RhoGDI alpha(INDUCES) 14506284 1 2 29 Cdc42 Y64A mutant is impaired in transforming NIH 3T3 cells. +LCP2 SLP76 Adaptor/scaffold Q13094 3937 5q35.1 human K284-sm 1878271703 EHLPKIQkPPLPPTT transcription, induced 31666306 1 1 0 enhances NFAT-driven IL-2 transcription +ABL1 Abl EC 2.7.10.2; KINASE; Kinase, protein; Oncoprotein; Protein kinase, TK; Protein kinase, tyrosine (non-receptor) P00519 25 9q34.12 human Y253-p 450301 HKLGGGQyGEVYEGV PK_Tyr_Ser-Thr intracellular localization; protein conformation; enzymatic activity, induced 18775312; 21347248 4 8 277 +LRRK1 LRRK1 EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, Ser/Thr (non-receptor); Protein kinase, TKL Q38SD2 79705 15q26.3 human Y971-p 23303206 TQQTEEQyFQFLAKF COR intracellular localization; enzymatic activity, inhibited endocytosis, altered 22337768; 36744428 2 0 0 regulates endosomal trafficking of EGFR +ESCO2 ESCO2 ACETYLTRANSFERASE; Acetyltransferase; DNA replication; EC 2.3.1.- Q56NI9 157570 8p21.1 human S196-p 1881957102 SNAPRVLsQKIKPQV molecular association, regulation; intracellular localization carcinogenesis, induced; DNA repair, induced MDC1(INDUCES) 37377435 1 0 0 +Cry2 CRY2 DNA-binding; Lyase Q9R194 12953 2|2 E1 mouse K241-ub 22242792 EALARLDkHLERKAW protein degradation; intracellular localization 23452856 1 2 0 +PTPRCAP PTPRCAP Cell surface; Membrane protein, integral Q14761 5790 11q13.2 human S163-p 4733815 EGDLVLGsPGPASAG PTPRCAP signaling pathway regulation 31537385 3 1 1 PKC, MAPK pathway +Dgka DGKA EC 2.7.1.107; Kinase, lipid; Lipid Metabolism - glycerolipid; Lipid Metabolism - glycerophospholipid; Motility/polarity/chemotaxis O88673 13139 10 D3|10 77.14 cM mouse Y336-p 486452 ILPPCSIyPSVLVSG intracellular localization 17911109 5 0 0 translocates to the plasma membrane after stimulation of endogenous T cell receptor (TCR) with anti-CD3/C28 +CDH5 CDH5 Cell adhesion; Membrane protein, integral; Motility/polarity/chemotaxis P33151 1003 16q21 human Y685-p 455658 LDARPSLyAQVQKPP receptor internalization, induced; molecular association, regulation CSK(INDUCES) 16909109; 33712448 18 4 145 +Nfatc2 NFAT1 DNA-binding; Transcription factor Q60591 18019 2 H3|2 88.91 cM mouse T116-p 455763 PSPRIEItPSHELMQ activity, induced; molecular association, regulation transcription, induced PPP3CA(INDUCES) 15743762 1 4 0 +ENO1 ENO1 Carbohydrate Metabolism - glycolysis and gluconeogenesis; EC 4.2.1.11; Lyase; Transcription, coactivator/corepressor P06733 2023 1p36.23 human S115-p 55578724 ANAILGVsLAVCKAG Enolase_N enzymatic activity, inhibited 27153534 1 1 0 +TP53BP1 53BP1 DNA repair, damage; Transcription, coactivator/corepressor Q12888 7158 15q15.3 human S380-p 452380 TPFIVPSsPTEQEGR molecular association, regulation DNA repair, induced SCAI(INDUCES) 28700933 3 59 6 other sites are involved in binding to SCAI +Kcnma1 KCNMA1 iso5 Channel, potassium; Endoplasmic reticulum; Membrane protein, integral; Membrane protein, multi-pass Q08460-5 16531 14|14 A3 mouse S692-p 27842903 SNVKKYDsTGMFHWC activity, induced 23407708 1 0 0 regulates NO/cGMP signaling +ARHGAP35 GRF-1 GAP; GAP, Rac/Rho; Motility/polarity/chemotaxis; Transcription factor; Tumor suppressor Q9NRY4 2909 19q13.32 human T1226-p 7159800 LRSLRRNtKKPKPKP RhoGAP_pG1_pG2 molecular association, regulation; activity, inhibited cytoskeletal reorganization 19103606; 19673492 2 0 1 prevents the association of the protein with acidic phospholipids and modulate the GTPase substrate preference +SRF SRF Motility/polarity/chemotaxis; Transcription factor P11831 6722 6p21.1 human S253-p 13203801 LTYQVSEsDSSGETK transcription, inhibited 8375385 1 1 0 +ADD1 ADD1 Cytoskeletal; Motility/polarity/chemotaxis P35611 118 4p16.3 human T445-p 449480 QKQQREKtRWLNSGR activity, induced; intracellular localization cytoskeletal reorganization 10209029; 15910744 6 0 0 Phosphorylation at T445 induced by STA2 translocated p-T445 into triton insoluble low speed fraction while p-S726 did not show any translocation of fractions. This translocation was inhibited by Y27632. ; phosphorylation of this site by Rho-kinase regulates membrane ruffling and cell motility. +CCNB1 CCNB1 Activator; Cell cycle regulation P14635 891 5q13.2 human S133-p 448445 SPSPMETsGCAPAEE intracellular localization DNA(INDUCES) 11242082; 12447691; 20117088; 22726437 7 1 0 S133-p is required for accelerated nuclear import. ; The phosphorylation of S133 and S147 is necessary for the nuclear translocation of cyclin B1 during G2/M phase.; enhances nuclear import +RIPK1 RIPK1 EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, Ser/Thr (non-receptor); Protein kinase, TKL Q13546 8737 6p25.2 human K115-ub 2188101 MSTPLSVkGRIILEI PK_Tyr_Ser-Thr phosphorylation transcription, induced; signaling pathway regulation 27518435 3 3 0 induces necroptotic cell death signaling +SLAMF6 SLAMF6 Membrane protein, integral; Receptor, misc. Q96DU3 114836 1q23.2-q23.3 human Y309-p 457710 ENDTITIySTINHSK molecular association, regulation; phosphorylation cell adhesion, induced; signaling pathway regulation Lck(INDUCES); SH2D1A(INDUCES) 24688028; 31199820 2 9 269 necessary for ERK phosphorylation +MAP2K2 MEK2 EC 2.7.12.2; KINASE; Kinase, protein; Protein kinase, STE; Protein kinase, dual-specificity (non-receptor) P36507 5605 19p13.3 human T394-p 452289 LRLNQPGtPTRTAV_ phosphorylation; enzymatic activity, induced 33226073 3 56 62 induces ERK1/2 phosphorylation +ZAP70 ZAP70 EC 2.7.10.2; KINASE; Kinase, protein; Protein kinase, TK; Protein kinase, tyrosine (non-receptor) P43403 7535 2q11.2 human Y598-p 464392 QRMRACYySLASKVE enzymatic activity, altered transcription, altered 9624129 1 1 173 +MRE11 MRE11A Cell cycle regulation; DNA repair, damage; DNA-binding; Deoxyribonuclease P49959 4361 11q21 human T481-p 11506400 VKYQLEKtQRFLKER molecular association, regulation DNA(DISRUPTS) 19709933 1 0 0 +INSR INSR EC 2.7.10.1; KINASE; Kinase, protein; Membrane protein, integral; Protein kinase, TK; Protein kinase, tyrosine (receptor) P06213 3643 19p13.2 human Y992-p 451597 DGPLGPLyASSNPEY enzymatic activity, inhibited 8024702 3 0 0 +PPP1R12A MYPT1 Motility/polarity/chemotaxis; PHOSPHATASE; Protein phosphatase, regulatory subunit O14974 4659 12q21.2-q21.31 human S473-p 3174680 GVTRSASsPRLSSSL molecular association, regulation; enzymatic activity, inhibited cell cycle regulation PPP2R2C(DISRUPTS); PPP2R3B(INDUCES); PPP2R5C(DISRUPTS); PPP2R3A(INDUCES) 32900880 2 9 7 +Itpr1 IP3R1 Channel, calcium; Channel, ligand-gated; Membrane protein, integral; Membrane protein, multi-pass P11881 16438 6 E1|6 49.74 cM mouse T799-p 450269 RDPQEQVtPVKYARL activity, induced 26259730 4 0 0 enhance Ca2+ oscillations, enhance the sensitivity of IP3R1 +NEK11 NEK11 EC 2.7.11.1; KINASE; Kinase, protein; Nucleolus; Protein kinase, Other; Protein kinase, Ser/Thr (non-receptor) Q8NG66 79858 3q22.1 human S273-p 10433801 SMLNKNPsLRPSAIE Pkinase enzymatic activity, induced 19734889 1 0 0 +MED12 MED12 Nuclear receptor co-regulator; Transcription, coactivator/corepressor Q93074 9968 Xq13.1 human R1912-m2 15381293 VPQGQRLrQQLQQSQ Med12-PQL molecular association, regulation transcription, inhibited DNA(INDUCES) 26601288 1 1 14 p21/WAF1 transcription +Ulk1 ULK1 Autophagy; EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, Other; Protein kinase, Ser/Thr (non-receptor) O70405 22241 5|5 F mouse S405-p 23070960 HGRTPSPsPTCSSSP molecular association, regulation; phosphorylation; enzymatic activity, induced carcinogenesis, induced; autophagy, induced LC3B(INDUCES); GABARAPL1(INDUCES) 33654220 1 0 1 induces phosphorylation of itself at the other site and of BECN1 and ATG13 +Elk1 ELK1 DNA-binding; Transcription factor P41969 13712 X A1.3|X 16.45 cM mouse T418-p 452139 ISVDGLStPVVLSPG molecular association, regulation transcription, inhibited Trap100(DISRUPTS); MED23(DISRUPTS); MED16(DISRUPTS) 27738173 8 0 1 +ACTN4 ACTN4 Cytoskeletal; Motility/polarity/chemotaxis O43707 81 19q13.2 human Y11-p 397383606 YHAANQSyQYGPSSA molecular association, regulation cell motility, inhibited ACTB(DISRUPTS) 29274473 1 0 0 slightly decreases binding; enhances invasion of melanoma cell line; decreases the susceptibility to m-calpain cleavage +ISCU ISCU Mitochondrial Q9H1K1 23479 12q23.3 human S14-p 469833 FRLRRAAsALLLRSP protein stabilization; molecular association, regulation 14-3-3 beta(INDUCES) 21725060; 23508953 2 51 95 +Ghr GH receptor Membrane protein, integral; Receptor, cytokine P16310 25235 2q16 rat Y594-p 450480 DAEPVPDyTTVHTVK GHBP molecular association, regulation SHP-2(INDUCES) 10976913 3 1 0 Major SHP-2 interacting phosphorylation site. GHR-bound SHP-2 negatively regulates GHR/JAK2 and STAT5B signaling. +Cttn Cortactin Actin-binding; Cytoskeletal; Motility/polarity/chemotaxis Q60598 13043 7|7 F5 mouse K107-ac 36298743 VGHEYQSkLSKHCSQ HS1_rep molecular association, regulation; acetylation; intracellular localization DIP2A(INDUCES) 31600191 1 1 4 DIP2A regulates spine morphology and synaptic transmission through acetylation of cortactin; Interaction of DIP2A-cortactin is required for acetylated cortactin; acetylation mimetic cortactin rescues the repetitive behaviors in Dip2a KO mice; acetylation alleviated abnormal PSD95 clustering at the spine head in DIP2A KO neurons +BRCA2 BRCA2 DNA repair, damage; Nuclear receptor co-regulator; Tumor suppressor P51587 675 13q13.1 human T77-p 15418117 SYNQLAStPIIFKEQ molecular association, regulation cell cycle regulation PLK1(INDUCES); RAD51(INDUCES) 24448238; 24835992 2 1 4 +RPS15 RPS15 RNA-binding; Ribosomal P62841 6209 19p13.3 human T136-p 18913279 GRPGIGAtHSSRFIP translation, induced 24725412 1 3 0 neuronal degeneration; cap-dependent and cap-independent reporter translation +SNRPB snRNP B1 RNA processing; RNA splicing; RNA-binding; Spliceosome P14678 6628 20p13 human R181-m2 1308900 GPPPPMGrGAPPPGM molecular association, regulation SMN(INDUCES) 11720283 1 1 4 +RBM17 RBM17 RNA splicing; RNA-binding; Spliceosome Q96I25 84991 10p15.1 human S291-p 27936102 EKDASKKsDSNPLTE molecular association, regulation; phosphorylation cell motility, induced RNA(DISRUPTS) 23519612 1 2 0 induced cell invasion, enhanced Cortactin phosphorylation at ERK-dependent sites +HIF1A HIF1A Autophagy; DNA-binding; Transcription factor Q16665 3091 14q23.2 human S692-p 56589702 PRSPNVLsVALSQRT protein stabilization transcription, induced 27245613; 27245614 2 2 0 +STXBP5L STXBP5L Q9Y2K9 9515 3q13.33 human S766-p 25755182 PTSQSCSsGKRLSSA protein degradation 25002582 1 1 1 ; in a multiple residue S->D mutant +Grik5 GluR KA2 Channel, ligand-gated; Membrane protein, integral; Membrane protein, multi-pass Q63273 24407 1q21 rat S833-p 31033003 FIWSTRRsAESEEVS activity, induced 23066089 1 0 0 GluR KA2 mediated potentiation of heteromeric KARs +PSEN2 PSEN2 Cell surface; EC 3.4.23.-; Membrane protein, integral; Membrane protein, multi-pass; Protease P49810 5664 1q42.13 human S19-p 449962 EVCDERTsLMSAESP molecular association, regulation AP1G1(DISRUPTS) 27293189 2 1 0 +FYB2 ARAP Adaptor/scaffold Q5VWT5 199920 1p32.2 human Y587-p 56614903 KSQEVIIyDDVDLSE molecular association, regulation; intracellular localization signaling pathway regulation SLP76(INDUCES) 27335501 1 0 0 +YAP1 YAP1 Oncoprotein; Transcription, coactivator/corepressor P46937 10413 11q22.1 human S381-p 3190669 LRTMTTNsSDPFLNS protein degradation; ubiquitination; activity, inhibited carcinogenesis, altered; carcinogenesis, inhibited; cell growth, inhibited; cell motility, inhibited; cell growth, induced; cell motility, altered; transcription, inhibited; cell growth, altered 26265440; 28416665; 35210364; 36598329 11 6 0 +POU3F2 Oct7 DNA-binding; Motility/polarity/chemotaxis; Transcription factor P20265 5454 6q16.1 human S360-p 486486 RKRKKRTsIEVSVKG Homeodomain transcription, altered DNA(DISRUPTS) 17543985 3 1 0 Phosphorylation reduced binding to NORE and PORE, but not MORE motifs. +Csnk1d CK1D EC 2.7.11.1; EC 2.7.11.26; KINASE; Kinase, protein; Protein kinase, CK1; Protein kinase, Ser/Thr (non-receptor) Q06486 64462 10q32.3 rat T329-p 31869461 ATRGLPStASGRLRG enzymatic activity, inhibited 26803658 2 2 1 +BLM BLM DNA repair, damage; DNA replication; EC 3.6.4.12; Helicase P54132 641 15q26.1 human T182-p 41290000 SHFVRVStAQKSKKG BLM_N protein degradation; ubiquitination 26028025 1 0 0 during mitosis +REEP4 REEP4 Membrane protein, integral; Membrane protein, multi-pass Q9H6H4 80346 8p21.3 human S152-p 3212556 AGRLRSFsMQDLRSI molecular association, regulation 14-3-3 beta(INDUCES) 21725060 1 68 93 mutation of this site prevents 14-3-3 binding (pan-14-3-3 antibody) +ZBTB16 PLZF C2H2-type zinc finger protein; DNA-binding; Oncoprotein; Transcription, coactivator/corepressor Q05516 7704 11q23.2 human K647-ac 50455003 PSLSSMQkHMKGHKP molecular association, regulation; acetylation; intracellular localization chromatin organization, altered; transcription, inhibited DNA(INDUCES) 26405459 1 0 0 induces histone acetylation and DNA hypermethylation +Jak2 JAK2 EC 2.7.10.2; KINASE; Kinase, protein; Oncoprotein; Protein kinase, TK; Protein kinase, tyrosine (non-receptor) Q62689 24514 1q52 rat Y1008-p 448408 LPQDKEYyKVKEPGE PK_Tyr_Ser-Thr enzymatic activity, induced 15065871 77 2 16 +Trim28 TIF1B EC 6.3.2.-; KINASE; Kinase, protein; Ligase; Nuclear receptor co-regulator; Protein kinase, atypical; SUMO LIGASE; SUMO ligase; Transcription, coactivator/corepressor; UBIQUITIN LIGASE; Ubiquitin conjugating system; Ubiquitin ligase O08629 116698 1q12 rat S825-p 460839 LPSAGLSsQELSGPG molecular association, regulation cell growth, induced; apoptosis, inhibited PCNA(INDUCES) 35799276 47 9 6 inhibits PCNA binding to CUL4A and hence its ubiquitination and degradation +RELA NFkB-p65 DNA-binding; Nuclear receptor co-regulator; Transcription factor Q04206 5970 11q13.1 human S276-p 447798 SMQLRRPsDRELSEP RHD_dimer protein degradation; acetylation; protein stabilization; molecular association, regulation; phosphorylation; activity, induced; ubiquitination; intracellular localization cell motility, induced; transcription, induced; signaling pathway regulation; transcription, altered; endocytosis, induced; cell growth, induced; apoptosis, inhibited; transcription, inhibited HDAC1(DISRUPTS); PKACA(INDUCES); RARB(INDUCES); eEF1B(INDUCES); CBP(INDUCES); RARA(INDUCES); p300(INDUCES); DNMT1(INDUCES); FBXW2(INDUCES) DNA(INDUCES) 11027313; 11931769; 12628924; 15516339; 17108032; 17114467; 17959673; 17991436; 18025230; 18362169; 18424438; 19197368; 19911008; 19933278; 20065107; 20364151; 20562110; 20639196; 21765477; 23100252; 23536830; 31574956; 31980577; 33594320; 34465889; 36264688; 36413416; 9660950 90 0 0 S276 phosphorylation inhibits interaction between N- and C-terminal domains of p65.; inhibits H3K9 acetylation +BAG3 BAG3 Apoptosis; Chaperone O95817 9531 10q26.11 human S289-p 469169 RSSTPLHsPSPIRVH molecular association, regulation; intracellular localization HSBP1(DISRUPTS) 27659916 2 46 47 +TBK1 TBK1 EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, Other; Protein kinase, Ser/Thr (non-receptor) Q9UHD2 29110 12q14.2 human S172-p 447732 EDDEQFVsLYGTEEY Pkinase molecular association, regulation; intracellular localization; phosphorylation; enzymatic activity, induced carcinogenesis, induced; cell motility, induced; transcription, induced; transcription, altered; signaling pathway regulation; DNA repair, induced; autophagy, induced; cell growth, induced; transcription, inhibited Other(INDUCES) 11839743; 21145761; 22851696; 23453972; 26376340; 27125670; 27538435; 28049762; 31332347; 31792381; 33411856; 33883226; 33990776; 34226595; 34343500; 35406696; 35868534; 36640307; 36928362 76 8 47 +Numb NUMB Cell development/differentiation Q2LC84 29419 6q24 rat S275-p 456490 EQLARQGsFRGFPAL NumbF molecular association, regulation AP2A1(DISRUPTS); AP2B1(DISRUPTS); 14-3-3 eta(INDUCES) 17022975 4 18 7 +Il2rb IL2RB Membrane protein, integral; Receptor, cytokine P16297 16185 15 E1|15 37.52 cM mouse Y367-p 455360 SCFTNQGyFFFHLPN intracellular localization 27799311 5 0 0 transport CBP from the nucleus to the cytoplasm +G6PD G6PD iso3 Carbohydrate Metabolism - pentose phosphate pathway; Cell development/differentiation; EC 1.1.1.49; Other Amino Acids Metabolism - glutathione; Oxidoreductase P11413-3 2539 Xq28 human T266-p 15207800 NIACVILtFKEPFGT G6PD_C enzymatic activity, induced 20649491 1 0 0 +CDK1 CDK1 Cell cycle regulation; EC 2.7.11.22; EC 2.7.11.23; KINASE; Kinase, protein; Motility/polarity/chemotaxis; Protein kinase, CMGC; Protein kinase, Ser/Thr (non-receptor) P06493 983 10q21.2 human T14-p 447608 IEKIGEGtYGVVYKG Pkinase intracellular localization; enzymatic activity, inhibited; phosphorylation cell cycle regulation; carcinogenesis, induced; cell growth, induced; transcription, induced 10504341; 11782384; 12912980; 1532335; 20360007; 21602434; 21900495; 34370741; 35444283; 35738066; 36163549; 8441405; 9268380 34 117 1764 +HSF1 HSF1 DNA-binding; Transcription factor Q00613 3297 8q24.3 human S344-p 455485 ESEPAPAsVTALTDA Vert_HS_TF transcription, inhibited 25963659 2 4 1 under non-stressed conditions, upon heat shock S to A mutant showed 60% higher luciferase activity +LTB4R2 LTB4R2 GPCR, family 1; Membrane protein, integral; Membrane protein, multi-pass; Motility/polarity/chemotaxis; Receptor, GPCR Q9NPC1 56413 14q12 human T324-p 12267086 GGRSREGtMELRTTP TM molecular association, regulation cell motility, induced RANBP9(DISRUPTS) 22044535; 23928309 2 0 0 +NCF1 p47phox EC 1.-.-.-; Oxidoreductase P14598 653361 7q11.23 human S315-p 451725 AHSIHQRsRKRLSQD NECFESHC molecular association, regulation; enzymatic activity, induced signaling pathway regulation CYBA(INDUCES) 12056906; 31736979; 35108370 14 0 0 LPS-induced activation of p38MAPK and ERK1/2 signaling pathways +STAT5B STAT5B DNA-binding; Oncoprotein; Transcription factor P51692 6777 17q21.2 human Y699-p 448198 TAKAVDGyVKPQIKQ activity, induced; molecular association, regulation; phosphorylation cell cycle regulation; transcription, induced; transcription, altered Bcr(INDUCES); Hck(INDUCES) DNA(INDUCES) 11751923; 12411494; 16772534; 16862179; 17822672; 17997837; 18430728; 18550772; 23980167 45 45 2242 increases pSTAT5B at Y699 +DEPTOR DEPTOR Apoptosis Q8TB45 64798 8q24.12 human S286-p 21697912 SSMSSCGsSGYFSSS protein degradation; molecular association, regulation; ubiquitination BTRC(INDUCES); FBW1B(INDUCES) 22017875; 22017876; 22017877 3 1 0 +Ryr2 RYR2 Channel, ligand-gated; Membrane protein, integral; Membrane protein, multi-pass; Transporter; Transporter, ion channel E9Q401 20191 13 A1|13 4.38 cM mouse S2807-p 448848 YNRTRRIsQTSQVSI activity, induced; molecular association, regulation exocytosis, altered FKBP1B(DISRUPTS) 16407108; 20615971; 22939628 57 5 3 calcium release, cardiomyopathy and increased mortality in mdx mice; stress-induced cognitive dysfunction; RyR2 S2808A mutation in mice improves cardiac functions after myocardial infarction; Stress induced calcium leak in channels +Gabrg2 GABRG2 Channel, chloride; Channel, ligand-gated; Membrane protein, integral; Membrane protein, multi-pass; Transporter; Transporter, ion channel Q6PW52 29709 10q21 rat S381-p 452033 NPLLRMFsFKAPTID Neur_chan_memb intracellular localization 15235089 4 3 2 +Alx1 Cart1 DNA-binding Q63087 25401 7q21 rat K131-ac 459028 DSNVSSSkKRRHRTT transcription, induced 12929931 1 0 0 +Ppp1r9a neurabin 1 Adaptor/scaffold; Protein phosphatase, regulatory subunit O35867 84685 4q13 rat S461-p 455523 ANRKIKFsCAPIKVF PDZ_5 molecular association, regulation; receptor internalization, inhibited p70S6K(INDUCES); PPP1CA(INDUCES); PPP1CA(DISRUPTS) 12052877; 29383693 3 0 1 interferes with LTD induction +MRAS MRas G protein; G protein, monomeric; G protein, monomeric, Ras; Oncoprotein O14807 22808 3q22.3 human K127-ub 1879723002 PMILVANkVDLMHLR protein degradation 31337872 1 0 0 other residues may be involved in degradation +Pde5a PDE5A EC 3.1.4.35; Nucleotide Metabolism - purine; Phosphodiesterase Q8CG03 242202 3|3 G1 mouse S92-p 448178 GAPARKIsASEFDRP cell adhesion, induced 35767715 8 6 0 +CBLB Cbl-b Adaptor/scaffold; Calcium-binding; EC 6.3.2.-; Ligase; UBIQUITIN LIGASE; Ubiquitin conjugating system; Ubiquitin ligase Q13191 868 3q13.11 human Y665-p 451550 GHLGSEEyDVPPRLS molecular association, regulation CRKL(INDUCES) 10022120 3 6 117 in vitro and vivo; Y709 is major binding site, and to lesser extent Y665 +NCL NCL DNA-binding; Helicase; Nuclear receptor co-regulator; Nucleolus; RNA-binding P19338 4691 2q37.1 human S206-p 466007 DDDEEDDsEEEAMET intracellular localization cell cycle regulation; cell growth, induced 25313645 2 24 36 +FOXO1 FOXO1A DNA-binding; Nuclear receptor co-regulator; Oncoprotein; Transcription factor Q12778 2308 13q14.11 human S276-p 1253812002 RAAKKKAsLQSGQEG protein stabilization; intracellular localization 30201683 4 1 0 +Cebpb C/EBP-beta DNA-binding; Motility/polarity/chemotaxis; Transcription factor P21272 24253 3q42 rat K217-ac 458940 PAKAKAKkAVDKLSD transcription, inhibited 24344329 4 1 0 +Sh2b1 SH2-B-beta Adaptor/scaffold Q62985 89817 1q36 rat Y494-p 448754 VHPLSTPyPPLDTPE cell motility, induced; cytoskeletal reorganization 12551917; 23444381 2 0 0 membrane ruffling; macrophage migration +IGF2BP1 IGF2BP1 RNA-binding; Translation Q9NZI8 10642 17q21.32 human S181-p 453893 RGQPRQGsPVAAGAP carcinogenesis, induced; apoptosis, inhibited; RNA stability, induced; translation, inhibited 33388443 3 59 12 +ADD1 ADD1 Cytoskeletal; Motility/polarity/chemotaxis P35611 118 4p16.3 human T480-p 449481 TKEDGHRtSTSAVPN activity, induced 10209029 1 1 0 phosphorylation of this site by Rho-kinase regulates membrane ruffling and cell motility. +INSR INSR EC 2.7.10.1; KINASE; Kinase, protein; Membrane protein, integral; Protein kinase, TK; Protein kinase, tyrosine (receptor) P06213 3643 19p13.2 human S1217-p 3103702 DGVFTTSsDMWSFGV PK_Tyr_Ser-Thr enzymatic activity, induced 10866039 1 0 0 +FUNDC1 FUNDC1 Membrane protein, multi-pass; Mitochondrial Q8IVP5 139341 Xp11.3 human S17-p 2025377 DYESDDDsYEVLDLT activity, induced; molecular association, regulation; protein conformation carcinogenesis, induced; autophagy, induced LC3B(INDUCES); LC3A(INDUCES) 24671035; 27757847; 36425056; 36927870 6 7 0 selective mitophagy; induces mitophagy; Mitophagy induced +DDX39A DDX39 EC 3.6.4.13; Helicase; RNA splicing; RNA-binding O00148 10212 19p13.12 human K154-sm 55429506 FFGGLSIkKDEEVLK DEAD molecular association, regulation RNA(DISRUPTS) 32393512 1 3 0 +MEGF10 MEGF10 Membrane protein, integral Q96KG7 84466 5q23.2 human Y1030-p 12186245 LSSSENPyATIKDPP molecular association, regulation cell growth, induced Notch 1(INDUCES) 23954233; 28498977 2 0 1 +Myocd myocardin Cell development/differentiation; Transcription factor Q8VIM5 214384 11|11 B3 mouse T893-p 10791203 TMEWLDLtPPSSTPG molecular association, regulation transcription, inhibited CBP(DISRUPTS) 19776005 1 0 0 +DLC1 DLC1 GAP; GAP, Rac/Rho; Tumor suppressor Q96QB1 10395 8p22 human S735-p 15499997 MVRKRSVsNSTQTSS molecular association, regulation; intracellular localization; protein conformation; activity, inhibited cell growth, induced RHOA(DISRUPTS); DLC1(INDUCES) 29114068 1 2 1 greatly attenuates its RhoGAP and tumor-suppressor functions; becomes monomer; alters its focal adhesion (FA) localization +BCL2 Bcl-2 Apoptosis; Autophagy; Membrane protein, integral; Oncoprotein P10415 596 18q21.33 human T69-p 448398 SRDPVARtSPLQTPA molecular association, regulation apoptosis, altered; apoptosis, induced; apoptosis, inhibited BAX(INDUCES); beclin 1(DISRUPTS); p53(DISRUPTS) 15703383; 16738310; 17097560; 18570871; 19029119; 34064109 11 0 0 +Becn1 beclin 1 Adaptor/scaffold; Autophagy; Membrane protein, peripheral O88597 56208 11|11 D mouse K414-ac 1881258602 SGGSYSIkTQFNSEE autophagy, induced; cell differentiation, induced 34085745 1 0 0 adipocyte differentiation, induces lipolysis +Chpt1 CHPT1 EC 2.7.8.2; Lipid Metabolism - ether lipid; Lipid Metabolism - glycerophospholipid; Membrane protein, integral; Membrane protein, multi-pass; Transferase Q8C025 212862 10|10 C1 mouse K284-ub 12718509 LAIMIYKkSATNMFE protein degradation; enzymatic activity, inhibited 20018880 1 0 0 +RAD51 RAD51 DNA repair, damage; Mitochondrial Q06609 5888 15q15.1 human K338-ac 1873284316 ADGVGDAkD______ DNA repair, inhibited 28869605 1 0 0 +SMCR8 SMCR8 Unknown function Q8TEV9 140775 17p11.2 human S402-p 55469601 QDRPPSSsLEECPIP autophagy, induced 27103069 1 0 0 +PINX1 PINX1 Inhibitor; Nucleolus; Tumor suppressor Q96BK5 54984 8p23.1 human T141-p 14823403 DLSSRSKtDLDCIFG protein degradation; ubiquitination 20573420 1 2 0 +BCL2L12 Bcl-2L12 Apoptosis Q9HB09 83596 19q13.33 human S156-p 9258022 SESPRPCsLPIRPCY protein conformation autophagy, induced; apoptosis, inhibited 22262180; 29749471 2 0 7 +KDR VEGFR2 EC 2.7.10.1; KINASE; Kinase, protein; Membrane protein, integral; Protein kinase, TK; Protein kinase, tyrosine (receptor) P35968 3791 4q12 human Y1059-p 447900 DIYKDPDyVRKGDAR PK_Tyr_Ser-Thr molecular association, regulation; receptor internalization, altered; phosphorylation; enzymatic activity, induced cell cycle regulation; cell differentiation, altered; cell growth, induced; cell growth, altered Src(INDUCES); PLCG1(INDUCES); CBL(INDUCES) 10102632; 11435426; 16891660; 16946136; 17372230; 19050761 16 3 110 +HTT Huntingtin Cytoskeletal P42858 3064 4p16.3 human K6-sm 8545504 __MATLEkLMKAFES protein stabilization; intracellular localization transcription, inhibited 15064418 2 0 0 +Dok1 DOK1 Adaptor/scaffold; Motility/polarity/chemotaxis P97465 13448 6 C3|6 35.94 cM mouse Y361-p 448367 DSKEDPIyDEPEGLA molecular association, regulation cell growth, inhibited; cytoskeletal reorganization RASA1(INDUCES); NCK1(INDUCES) 10202139; 12087092; 15148308; 25043303 9 27 497 +Nox1 NOX1 Channel, misc.; EC 1.-.-.-; Membrane protein, integral; Membrane protein, multi-pass; Motility/polarity/chemotaxis; Oxidoreductase Q9WV87 114243 Xq32 rat T429-p 36552501 RAHNKLKtQKIYFYW NAD_binding_6 molecular association, regulation; enzymatic activity, induced cell motility, induced NOXA1(INDUCES) 25228390 1 1 0 NADPH oxidase activity induced, ROS production increased, Cell migration induced +Mybpc3 MYBPC3 Myosin-binding O70468 17868 2|2 E1 mouse S302-p 471081 SLLKKRDsFRRDSKL activity, induced; molecular association, regulation; intracellular localization; protein conformation apoptosis, altered; cytoskeletal reorganization MYBPC1(DISRUPTS) 17075052; 21978630; 22752314; 24951619; 25740838; 26908877; 28167762; 28345052 28 6 0 phosphorylation weakens this stabilization and binding of the heads to the backbone, increasing the probability of their interacting with the thin filament +PIP4K2A PIP4K2A Carbohydrate Metabolism - inositol phosphate; EC 2.7.1.149; Kinase, lipid; Motility/polarity/chemotaxis P48426 5305 10p12.2 human T376-p 460716 KAAHAAKtVKHGAGA PIP5K enzymatic activity, inhibited 16563698 1 0 0 +Ppargc1b PGC-1 beta Nuclear receptor co-regulator; Transcription, coactivator/corepressor Q8VHJ7 170826 18|18 E1 mouse K455-ac 7761212 EEEEWGRkRPGRGLP intracellular localization transcription, inhibited 19491097 1 1 0 +Dlg1 DLG1 Adaptor/scaffold; Motility/polarity/chemotaxis Q811D0 13383 16 B2|16 22.4 cM mouse Y222-p 35530400 GTDADYEyEEITLER MAGUK_N_PEST phosphorylation transcription, induced; signaling pathway regulation 25098293 1 0 0 p38A phosphorylation, TCR-dependent signaling pathway +Rps6 S6 Translation P62755 29304 5q32 rat S236-p 448093 AKRRRLSsLRASTSK signaling pathway regulation 21949366 239 72 1124 +DAZAP1 DAZAP1 Motility/polarity/chemotaxis; RNA-binding Q96EP5 26528 19p13.3 human T269-p 467204 FTSYIVStPPGGFPP molecular association, regulation DAZ1(DISRUPTS) 16848763 1 0 0 +ITGB1 ITGB1 Cell adhesion; Cell surface; Membrane protein, integral; Motility/polarity/chemotaxis; Receptor, misc. P05556 3688 10p11.22 human T788-p 448600 PIYKSAVtTVVNPKY Integrin_b_cyt activity, induced; molecular association, regulation; protein conformation cell adhesion, induced; cell motility, altered; cell adhesion, altered FLNA(DISRUPTS); kindlin-2(DISRUPTS); talin 1(DISRUPTS) 14660602; 15949469; 16405888; 19115199; 33119040 15 2 1 +SUFU SUFU Adaptor/scaffold; Transcription, coactivator/corepressor; Tumor suppressor Q9UMX1 51684 10q24.32 human K257-ub 5009206 HLQERVDkGIETDGS SUFU_C protein degradation cell growth, induced; transcription, induced 18997815 1 1 0 +SLC12A1 NKCC2 Membrane protein, integral; Membrane protein, multi-pass; Transporter; Transporter, SLC family Q13621 6557 15q21.1 human T100-p 458227 TNTYYLQtFGHNTMD AA_permease_N signaling pathway regulation 21321328 15 2 0 WNK-SPAK-OSR1 pathway +Raf1 RAF1 EC 2.7.11.1; KINASE; Kinase, protein; Oncoprotein; Protein kinase, Ser/Thr (non-receptor); Protein kinase, TKL Q99N57 110157 6 E3|6 53.62 cM mouse Y341-p 447750 GQRDSSYyWEIEASE phosphorylation; enzymatic activity, induced apoptosis, altered 10205168; 11296227; 17535812 35 1 1 Bad Ser 112 + 136 phosphorylation +ETS2 Ets-2 DNA-binding; Oncoprotein; Transcription factor P15036 2114 21q22.2 human S248-p 54126001 KSRLSSVsVTYCSVS Ets1_N_flank protein degradation 26871468 1 0 0 CDK10 mediated degradation +AURKA AurA EC 2.7.11.1; KINASE; Kinase, protein; Oncoprotein; Protein kinase, Other; Protein kinase, Ser/Thr (non-receptor) O14965 6790 20q13.2 human R304-me 1881955600 PPEMIEGrMHDEKVD enzymatic activity, induced 37370099 1 0 0 +BCAT2 BCAT2 Amino Acid Metabolism - valine, leucine and isoleucine biosynthesis; Amino Acid Metabolism - valine, leucine and isoleucine degradation; Cofactor and Vitamin Metabolism - pantothenate and CoA biosynthesis; EC 2.6.1.42; Mitochondrial; Transferase O15382 587 19q13.33 human K229-ub 21129876 VGGVGNYkLGGNYGP Aminotran_4 protein degradation; enzymatic activity, induced cell growth, induced 35663242 1 1 0 +YAP1 YAP1 iso2 Oncoprotein; Transcription, coactivator/corepressor P46937-2 10413 11q22.1 human S384-p 9764918 SRDESTDsGLSMSSY ubiquitination carcinogenesis, inhibited BTRC(INDUCES) 20048001 2 8 0 +CLDN11 Claudin-11 Cell adhesion; Membrane protein, integral; Membrane protein, multi-pass O75508 5010 3q26.2 human Y192-p 478786 FGENRFYyTAGSSSP molecular association, regulation cell motility, altered Src(INDUCES) 30664792 1 4 71 +PRPS1 PRPS1 Carbohydrate Metabolism - pentose phosphate pathway; EC 2.7.6.1; Kinase, other; Nucleotide Metabolism - purine P60891 5631 Xq22.3 human S285-p 1874748500 EDKMKHCsKIQVIDI Pribosyl_synth protein degradation; molecular association, regulation; ubiquitination carcinogenesis, inhibited; cell growth, inhibited TRAF2(INDUCES) 34465890 1 1 0 +XRCC1 XRCC1 DNA repair, damage P18887 7515 19q13.31 human T519-p 451450 EDPYAGStDENTDSE molecular association, regulation; intracellular localization PARP1(DISRUPTS); APTX(INDUCES); Pnk1(INDUCES) 15066279; 15367657; 25477519 3 5 5 +TUBG1 TUBG1 Cytoskeletal; Motility/polarity/chemotaxis P23258 7283 17q21.2 human S131-p 10045600 READGSDsLEGFVLC Tubulin intracellular localization cell cycle regulation 19648910 2 1 0 regulates centrosome biogenesis and homeostasis +CAST calpastatin Inhibitor P20810 831 5q15 human S655-p 25733148 QDPIDALsGDLDSCP activity, induced 29581866 1 5 1 +Emd emerin Cytoskeletal; Membrane protein, integral O08579 13726 X A7.3|X 37.92 cM mouse Y75-p 451787 AAVDSDMyDLPKKED cell motility, induced; transcription, induced; cytoskeletal reorganization 24609268 3 12 110 Y75F and Y96F had reduced expression of vinculin and SRF.; mechanical adaptation of isolated nuclei to force +MAD2L1 MAD2L1 Cell cycle regulation Q13257 4085 4q27 human S185-p 4326275 SEEVRLRsFTTTIHK HORMA intracellular localization; protein conformation 21041666; 23454898 2 3 1 +Prkcd PKCD EC 2.7.11.13; KINASE; Kinase, protein; Nuclear receptor co-regulator; Protein kinase, AGC; Protein kinase, Ser/Thr (non-receptor); Protein kinase, tyrosine (non-receptor); Tumor suppressor P09215 170538 16p16 rat S130-p 3194429 EDGDCKQsMRSEEEA phosphorylation; enzymatic activity, induced 26546672 1 10 1 downregulates phosphorylation of S357 +SNAI1 Snail1 C2H2-type zinc finger protein; Transcription factor O95863 6615 20q13.13 human K234-ub 231166703 LQTHSDVkKYQCQAC protein stabilization 28892081 1 0 0 metastasis +AMOT AMOT Q4VCS5 154796 Xq23 human K481-ub 40323316 EAYENLVkSSSKREA protein stabilization; ubiquitination; intracellular localization cell growth, inhibited 23564455 1 2 0 plasma membrane localization, induces YAP2 ubiquitination +KAT5 Tip60 ACETYLTRANSFERASE; Acetyltransferase; EC 2.3.1.48; Nuclear receptor co-regulator; Nucleolus Q92993 10524 11q13.1 human S90-p 448827 LPGSRPGsPEREVPA acetylation; protein stabilization; intracellular localization; enzymatic activity, induced; phosphorylation cell cycle regulation; DNA repair, induced; transcription, altered 16103124; 21658600; 26829474; 30297459 5 35 16 +MAP2 MAP2 Cytoskeletal; Motility/polarity/chemotaxis P11137 4133 2q34 human S1782-p 456422 GAEIITQsPGRSSVA molecular association, regulation; intracellular localization; protein conformation cytoskeletal reorganization; translation, inhibited TUBA1A(INDUCES); ACTB(INDUCES) 11029056; 33526823 2 63 14 reduce microtubule binding +NSD2 WHSC1 Amino Acid Metabolism - lysine degradation; EC 2.1.1.43; METHYLTRANSFERASE; Methyltransferase; Methyltransferase, protein lysine; Oncoprotein; Ubiquitin conjugating system O96028 7468 4p16.3 human S56-p 12667955 SKAQLSSsLQEGVMQ protein stabilization; ubiquitination; methylation carcinogenesis, induced; transcription, altered 35389552 1 4 0 inhibits ubiquitination of itself and induces methylation of histone +TP53BP1 53BP1 DNA repair, damage; Transcription, coactivator/corepressor Q12888 7158 15q15.3 human K1690-ub 40212810 GRKSATVkPGAVGAG DNA repair, induced 23874665 1 0 0 +TERT TERT DNA-binding; EC 2.7.7.49; Nucleolus; Transferase O14746 7015 5p15.33 human T249-p 1868023600 AAPEPERtPVGQGSW molecular association, regulation; enzymatic activity, induced carcinogenesis, induced; cell growth, induced; transcription, altered RNA(INDUCES) 32214089 2 1 0 induces RdRP activity, and binding to FOXO4 and RMRP RNA, reducing their transcription, alters transcription of other proteins +DDX5 DDX5 EC 3.6.4.13; Helicase; Nuclear receptor co-regulator; Nucleolus; RNA splicing; RNA-binding; Spliceosome P17844 1655 17q23.3 human K53-sm 12004408 WNLDELPkFEKNFYQ protein stabilization; molecular association, regulation chromatin organization, altered; transcription, induced; transcription, inhibited HDAC1(INDUCES) 17369852; 19995069 3 3 0 transcription of an estrogen response element +NACA NACA iso1 Motility/polarity/chemotaxis; Transcription, coactivator/corepressor Q13765 4666 12q13.3 human T174-p 3195872 EEEEVDEtGVEVKDI HYPK_UBA intracellular localization; activity, inhibited cell differentiation, inhibited; transcription, inhibited 30948508 1 10 1 +Nfatc1 NFAT2 DNA-binding; Transcription factor O88942 18018 18 E3|18 53.66 cM mouse K613-ac 9908948 SYPVIGGkKMVLSGH RHD_dimer protein stabilization; phosphorylation 32696520 1 0 1 hypoacetylation, induced higher phosphorylation, induces hair loss (regulated by Sirt7) +EPOR EPOR Membrane protein, integral; Receptor, cytokine P19235 2057 19p13.2 human Y504-p 449885 AEPLPPSyVACS___ apoptosis, inhibited 14662339 9 0 0 +ARHGAP35 GRF-1 GAP; GAP, Rac/Rho; Motility/polarity/chemotaxis; Transcription factor; Tumor suppressor Q9NRY4 2909 19q13.32 human Y1087-p 449570 DGFDPSDyAEPMDAV RhoGAP_pG1_pG2 molecular association, regulation cell motility, induced RASA1(INDUCES) 30664792; 32540970 4 38 1052 +PLA2G4A PLA2G4A EC 3.1.1.4; EC 3.1.1.5; Lipid Metabolism - alpha-linolenic acid; Lipid Metabolism - arachidonic acid; Lipid Metabolism - ether lipid; Lipid Metabolism - glycerophospholipid; Lipid Metabolism - linoleic acid; Phospholipase P47712 5321 1q31.1 human T268-p 3190702 HNPLLLLtPQKVKRY PLA2_B intracellular localization; protein conformation; enzymatic activity, induced 36351818 1 12 0 +AKT1S1 PRAS40 Apoptosis Q96B36 84335 19q13.33 human S221-p 2506802 DLDRIAAsMRALVLR PRAS molecular association, regulation; activity, inhibited 14-3-3 beta(INDUCES) 18372248 2 4 3 +APC APC Motility/polarity/chemotaxis; Tumor suppressor P25054 324 5q22.2 human S1360-p 3188801 EFSSGAKsPSKSGAQ APC_u9 cell cycle regulation 19703905 1 19 0 important for mitotic spindle anchoring to the cell cortex and orientation +SIGLEC10 Siglec-10 Cell adhesion; Membrane protein, integral Q96LC7 89790 19q13.41 human Y667-p 450087 ESQEELHyATLNFPG molecular association, regulation SHP-2(INDUCES); SHP-1(INDUCES) 11733002; 12163025 2 1 1 +Rb1 Rb Nuclear receptor co-regulator; Oncoprotein; Transcription, coactivator/corepressor; Tumor suppressor P13405 19645 14 38.73 cM|14 D3 mouse S243-p 447975 AAIPINGsPRTPRRG molecular association, regulation E2F1(DISRUPTS) 10207050; 35023164 19 45 86 +Map4k1 HPK1 EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, STE; Protein kinase, Ser/Thr (non-receptor) P70218 26411 7|7 B1 mouse S171-p 455474 ATLARRLsFIGTPYW Pkinase enzymatic activity, induced 17895239 3 1 13 +FOS Fos DNA-binding; Motility/polarity/chemotaxis; Oncoprotein; Transcription factor P01100 2353 14q24.3 human Y10-p 473043 FSGFNADyEASSSRC intracellular localization cell cycle regulation; cell growth, inhibited 17160021; 22105363 2 0 0 critical for association of Fos with endoplasmic reticulum membranes and phospholipid synthesis activation; inhibits phospholipid synthesis +AHR AHR DNA-binding; Transcription factor P35869 196 7p21.1 human S436-p 1874101916 LRTKNGTsGKDSATT protein degradation; ubiquitination autophagy, induced; transcription, induced 34198826 1 0 0 +STXBP1 STXBP1 Vesicle P61764 6812 9q34.11 human T574-p 454395 IGSTHILtPQKLLDT Sec1 exocytosis, inhibited 15273248 3 0 0 +CENPA CENPA DNA-binding P49450 1058 2p23.3 human K124-ac 1872903202 GRVTLFPkDVQLARR Histone molecular association, regulation cell cycle regulation CENPC1(DISRUPTS) 28396698 1 1 0 regulates timing timing of centromeric replication +NF2 Merlin Cytoskeletal; Motility/polarity/chemotaxis; Tumor suppressor P35240 4771 22q12.2 human K76-sm 31089523 KDTVAWLkMDKKVLD FERM_N protein stabilization; molecular association, regulation; intracellular localization carcinogenesis, inhibited; signaling pathway regulation Akt1(INDUCES) 24166499 1 0 0 refgulation of PI3K/Akt signaling +Cacna1b CACNA1B Channel, calcium; Membrane protein, integral; Membrane protein, multi-pass Q02294 257648 3p13 rat S425-p 465547 KRAATKKsRNDLIHA activity, inhibited 16704976; 19167461 2 1 0 +DLC1 DLC1 GAP; GAP, Rac/Rho; Tumor suppressor Q96QB1 10395 8p22 human S1004-p 34490415 RHRLRWHsFQSSHRP molecular association, regulation; intracellular localization; protein conformation; activity, inhibited cell growth, induced RHOA(DISRUPTS); DLC1(INDUCES) 29114068 1 1 0 greatly attenuates its RhoGAP and tumor-suppressor functions; becomes monomer; alters its focal adhesion (FA) localization +Cd274 PD-L1 Membrane protein, integral Q9EP73 60533 19|19 C1 mouse Y112-p 1015586 KLQDAGVyCCIISYG V-set carcinogenesis, induced; cell growth, induced 31305264 1 1 0 enhances the cancer immune escape +PBK PBK Cancer Testis Antigen (CTA); EC 2.7.12.2; KINASE; Kinase, protein; Protein kinase, Other; Protein kinase, Ser/Thr (non-receptor); Protein kinase, dual-specificity (non-receptor) Q96KB5 55872 8p21.1 human Y272-p 54400800 DFDDEAYyAALGTRP Pkinase protein stabilization; enzymatic activity, induced carcinogenesis, induced; cell motility, induced; cell growth, induced 27016416; 37016377 2 0 0 +MED12 MED12 Nuclear receptor co-regulator; Transcription, coactivator/corepressor Q93074 9968 Xq13.1 human R1862-m2 27270384 VDPYRPVrLPMQKLP Med12-PQL molecular association, regulation transcription, inhibited DNA(INDUCES) 26601288 1 1 5 p21/WAF1 transcription +KDM5A JARID1A DEMETHYLASE; Demethylase; EC 1.14.11.-; Nuclear receptor co-regulator; Nucleolus; Oxidoreductase; Transcription factor P29375 5927 12p13.33 human S225-p 36123496 TRRVKTQsESGDVSR intracellular localization 27292631 1 1 0 JARID1A recruitment to the promoters of AKT-regulated genes +BAZ1B WSTF DNA replication; EC 2.7.10.2; KINASE; Kinase, protein; Nuclear receptor co-regulator; Protein kinase, Ser/Thr (non-receptor); Protein kinase, tyrosine (non-receptor) Q9UIG0 9031 7q11.23 human K426-ac 9905197 GNSKSPKkGLKTPKT molecular association, regulation; phosphorylation; enzymatic activity, induced carcinogenesis, induced; cell growth, induced; transcription, induced H2AX(INDUCES) 32518374 1 1 1 promotes phosphorylation of WSTF at S158 +CDC25B CDC25B EC 3.1.3.48; Motility/polarity/chemotaxis; Nuclear receptor co-regulator; PHOSPHATASE; Protein phosphatase, dual-specificity P30305 994 20p13 human S151-p 7998663 FAIRRFQsMPVRLLG M-inducer_phosp molecular association, regulation 14-3-3 beta(INDUCES); 14-3-3 sigma(INDUCES); 14-3-3 epsilon(INDUCES) 21558810 3 13 26 +ZYX Zyxin Cell adhesion; Motility/polarity/chemotaxis Q15942 7791 7q34 human S142-p 460644 PQPREKVsSIDLEID molecular association, regulation; intracellular localization acinus(INDUCES); 14-3-3 gamma(INDUCES) 17572661 2 12 0 phosphorylation does not protect zyxin from proteolytic cleavage by caspase, but inhibits acinus degradation and suppresses apoptosis +Drd1 DRD1 GPCR, family 1; Membrane protein, integral; Membrane protein, multi-pass; Receptor, GPCR P18901 24316 17p14 rat S256-p 455301 NPVECAQsESSFKMS 7tm_1 receptor desensitization, altered 14660631 1 0 0 +Hcn1 HCN1 Membrane protein, integral; Membrane protein, multi-pass O88704 15165 13 D2.3|13 66.34 cM mouse S810-p 1877421604 EVRPLSAsQPSLPHE molecular association, regulation 14-3-3 zeta(INDUCES) 35679272 1 0 0 +Plk4 PLK4 EC 2.7.11.21; KINASE; Kinase, protein; Nucleolus; Protein kinase, Other; Protein kinase, Ser/Thr (non-receptor) Q64702 20873 3|3 B mouse S298-p 12654004 STTITASsGTSLSGS protein degradation; ubiquitination 20100909 2 1 0 +Snap23 SNAP23 Vesicle O09044 20619 2 60.37 cM|2 E5 mouse S120-p 455263 NVVSKQPsRITNGQP SNAP-25 protein stabilization exocytosis, altered; exocytosis, induced 18692471; 25083866; 25176657 9 2 0 granule exocytosis (mast cell degranulation); required for IKK2-mediated mast cells degranulation; stabilizes SNARE complex, important for phagosomal MHC-1 accumulation and cross-presentation +SEPTIN5 SEPT5 Cell cycle regulation; Cytoskeletal; Hydrolase; Vesicle Q99719 5413 22q11.21 human S327-p 454379 TQDSRMEsPIPILPL neural plasticity; autophagy, induced 34954322 2 27 2 +IGF1R IGF1R EC 2.7.10.1; KINASE; Kinase, protein; Membrane protein, integral; Protein kinase, TK; Protein kinase, tyrosine (receptor) P08069 3480 15q26.3 human S1313-p 2091904 DPSASSSsLPLPDRH activity, induced; phosphorylation cell differentiation, altered; apoptosis, altered; cell growth, altered 10746631; 10786694 2 0 0 observed in Y980F + S1310-1313A; ERK phosphorylation +Pten PTEN Carbohydrate Metabolism - inositol phosphate; EC 3.1.3.16; EC 3.1.3.48; EC 3.1.3.67; Motility/polarity/chemotaxis; Nuclear receptor co-regulator; PHOSPHATASE; Phosphatase, lipid; Tumor suppressor O08586 19211 19 C1|19 28.14 cM mouse S370-p 448649 TSVTPDVsDNEPDHY protein stabilization 20940307 12 7 0 +Notch3 NOTCH3 Membrane protein, integral Q61982 18131 17 B1|17 17.37 cM mouse K1692-ac 31089505 KDIAAGHkGRREPVG protein degradation; ubiquitination carcinogenesis, inhibited; cell growth, inhibited; transcription, inhibited; signaling pathway regulation 22120716 1 1 0 +Fndc5 FNDC5 Membrane protein, integral Q8K4Z2 384061 4|4 D2.2 mouse K127-ac 1881215704 KTPREAEkMASKNKD ubiquitination 33754067 1 0 0 SIRT2-dependent deacetylation and deubiquitination increases stability +Pycard PYCARD Adaptor/scaffold; Tumor suppressor Q9EPB4 66824 7|7 F3 mouse Y144-p 465096 SVLTEGQyQAVRAET CARD molecular association, regulation PYCARD(INDUCES) 35196496 4 2 4 +OPRK1 KOR-1 GPCR, family 1; Membrane protein, integral; Membrane protein, multi-pass; Receptor, GPCR P41145 4986 8q11.23 human K378-ub 1975300 RDIDGMNkPV_____ receptor internalization, induced; protein degradation 18212250 1 0 0 ubiquitination regulates but is not required for receptor downregulation +Kcnj6 GIRK2 Membrane protein, integral; Membrane protein, multi-pass P48550 25743 11q11 rat S9-p 4707737 TMAKLTEsMTNVLEG protein processing 19118198 2 1 0 regulates channel recycling to the membrane +MYL9 MRLC1 Contractile; Motility/polarity/chemotaxis P24844 10398 20q11.23 human S2-p 4964101 ______MsSKRAKAK intracellular localization cytoskeletal reorganization 22136066 5 0 0 +RPS6KA4 MSK2 EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, AGC; Protein kinase, Ser/Thr (non-receptor) O75676 8986 11q13.1 human S196-p 450046 EEKERTFsFCGTIEY Pkinase enzymatic activity, induced 10806207; 17429437 4 1 1 +Map3k3 MEKK3 EC 2.7.11.25; KINASE; Kinase, protein; Protein kinase, STE; Protein kinase, Ser/Thr (non-receptor) Q61084 26406 11|11 E1 mouse S526-p 458796 MSGTGIRsVTGTPYW Pkinase enzymatic activity, induced 14-3-3 epsilon(INDUCES) 16407301 4 2 0 interaction with 14-3-3 epsilon prevents dephosphorylation of S526. critical site for activation of ERK, p38 and JNK kinases. +RARA RARA DNA-binding; Nuclear receptor; Oncoprotein; Transcription factor P10276 5914 17q21.2 human T181-p 455328 CSESYTLtPEVGELI protein degradation; ubiquitination signaling pathway regulation 15657432; 21272161 2 0 0 retinoid signaling +AANAT AA-NAT ACETYLTRANSFERASE; Acetyltransferase; Amino Acid Metabolism - tryptophan; EC 2.3.1.87 Q16613 15 17q25.1 human T31-p 452141 PSCQRRHtLPASEFR molecular association, regulation 14-3-3 zeta(INDUCES) 28387381 4 0 0 +Ptpn2 PTPN2 EC 3.1.3.48; Motility/polarity/chemotaxis; PHOSPHATASE; Protein phosphatase, tyrosine (non-receptor) Q06180 19255 18|18 E1 mouse S52-p 23136003 RNRYRDVsPYDHSRV Y_phosphatase phosphorylation; enzymatic activity, induced carcinogenesis, induced; apoptosis, inhibited 37000627 1 4 2 dephosphorylates CD3Z +Map2 MAP2 Cytoskeletal; Motility/polarity/chemotaxis P15146 25595 9q32 rat T1622-p 450181 YSSRTPGtPGTPSYP molecular association, regulation cytoskeletal reorganization 25309320 3 21 7 fractionated with microtubules, protrusion growth, regulates basal dendrite architecture in vivo +KLF5 KLF5 C2H2-type zinc finger protein; DNA-binding; Transcription factor Q13887 688 13q22.1 human S153-p 10945600 LRTGLYKsQRPCVTH transcription, altered 12682370 1 1 0 S153A mutant moderately reduces transactivation. +Jak2 JAK2 EC 2.7.10.2; KINASE; Kinase, protein; Oncoprotein; Protein kinase, TK; Protein kinase, tyrosine (non-receptor) Q62120 16452 19 C1|19 23.73 cM mouse Y201-p 470070 DQTPLAVyNSVSYKT FERM_F2 molecular association, regulation SHP-2(INDUCES) 17027227 3 1 0 Jak2 phosphorylation mediates binding to SHP-2, which is in a complex with AT-1 +ALOX5 5-LO EC 1.13.11.34; Lipid Metabolism - arachidonic acid; Lipid Metabolism - linoleic acid; Nuclear envelope; Oxidoreductase P09917 240 10q11.21 human S524-p 452140 GMRGRKSsGFPKSVK Lipoxygenase intracellular localization; enzymatic activity, inhibited 15280375; 16230355; 26173130; 28257804 7 1 0 +Hnf4a HNF4 alpha DNA-binding; Nuclear receptor; Transcription factor P22449 25735 3q42 rat S142-p 458368 DRISTRRsSYEDSSL molecular association, regulation transcription, altered DNA(DISRUPTS) 9234678 4 4 6 +REL REL Oncoprotein; Transcription factor Q04864 5966 2p16.1 human S492-p 456135 ISDPNMLsNCSVNMM activity, induced transcription, induced 16585559 2 0 0 both site-directed S460A or previously characterized spontaneous S460N are not responsive to NIK-induced activation of transcription at the IL-2 promoter. S460N is also much less responsive to CD3- or CD3+CD28-induced transcriptional upregulation at the IL-2 promoter. +Mrtfa MKL1 Oncoprotein; Transcription, coactivator/corepressor Q8K4J6 223701 15|15 E1 mouse S487-p 4762839 VKFGSTGsTPPVSPT transcription, induced 33171330 1 5 2 regulates the expression of IL-6; regulates re-endothelialization +NOP53 GLTSCR2 Nucleolus Q9NZM5 29997 19q13.33 human S233-p 23110061 ARLHTKPsQAPAVEV Nop53 protein degradation; molecular association, regulation; intracellular localization apoptosis, induced RPL11(DISRUPTS) 27829214 1 0 1 +CD44 CD44 iso2 Cell adhesion; Membrane protein, integral; Motility/polarity/chemotaxis; Receptor, misc. P15379-2 12505 2 E2|2 54.13 cM mouse S325-p 465561 SELNGEAsKSQEMVH cell adhesion, induced 7528778 3 10 10 hyaluronate binding is diminished when this residue is mutated +HIF1A HIF1A Autophagy; DNA-binding; Transcription factor Q16665 3091 14q23.2 human K538-ub 6778620 FKLELVEkLFAEDTE protein degradation 16862177 1 5 0 +PRDX1 PRDX1 EC 1.11.1.15; Nuclear receptor co-regulator; Oxidoreductase Q06830 5052 1p34.1 human S32-p 15334103 QFKDISLsDYKGKYV AhpC-TSA protein conformation; enzymatic activity, induced apoptosis, altered 20647304 1 16 0 +Akt1 Akt1 EC 2.7.11.1; KINASE; Kinase, protein; Oncoprotein; Protein kinase, AGC; Protein kinase, Ser/Thr (non-receptor) P31750 11651 12 F1|12 61.2 cM mouse S473-p 447855 RPHFPQFsYSASGTA Pkinase_C protein degradation; acetylation; molecular association, regulation; phosphorylation; enzymatic activity, induced; activity, induced; ubiquitination; intracellular localization cell cycle regulation; carcinogenesis, induced; apoptosis, altered; cell motility, induced; RNA stability, induced; cell motility, inhibited; signaling pathway regulation; cell differentiation, altered; RNA splicing, induced; cell growth, induced; translation, induced; transcription, inhibited; cell growth, altered; carcinogenesis, inhibited; carcinogenesis, altered; cell growth, inhibited; transcription, induced; transcription, altered; neural plasticity; cell differentiation, induced; apoptosis, inhibited; autophagy, inhibited; cytoskeletal reorganization; translation, inhibited PPP2CA(INDUCES); PPP2R5B(INDUCES); HSP90A(NOT_REPORTED); CHIP(INDUCES) 10974038; 11375271; 11694516; 11818508; 11934884; 12032135; 12529330; 14522959; 14623889; 15082758; 17562705; 18570920; 18851840; 19061837; 19305428; 19325558; 20332342; 20530873; 21195350; 21329884; 21498666; 21550972; 21767636; 21775285; 21804606; 21847090; 21852229; 21956113; 21965330; 22388104; 22509246; 23359250; 24448243; 24498331; 24563481; 24614172; 25119572; 25143441; 26536663; 28600288; 31672472; 32116552; 32473126; 33048163; 33547375; 33664496; 33742122; 33786575; 33804171; 33836590; 33865855; 33869980; 34111424; 34118691; 34234346; 34298892; 34314419; 34343610; 34380537; 34473230; 34556581; 34608264; 34664403; 34694913; 34706731; 34710087; 34714866; 34910106; 34921114; 35210557; 35305679; 35358489; 35489019; 35641033; 35650206; 35896382; 35921893; 36012713; 36065437; 36192478; 36198369; 36263130; 36310322; 36473049; 36520801; 36870057; 36884349; 36997926; 37418003; 37439870; 37610873 1956 25 44 +Rhot1 RHOT1 EC 3.6.5.-; G protein; G protein, monomeric; G protein, monomeric, Rho; Hydrolase; Membrane protein, integral; Mitochondrial NP_001100496 303351 10q25-q26 rat K105-ac 11318024 NNKHSIDkVTSRWIP Ras cell growth, induced 31068376 1 1 0 increases mitochondrial transport and axon growth in DRG neurons +Mafa MAFA DNA-binding; Oncoprotein; Transcription factor; Tumor suppressor Q8CF90 378435 15|15 D3 mouse S14-p 1713900 MGAELPSsPLAIEYV molecular association, regulation MAFA(INDUCES) DNA(NOT_REPORTED) 20208071 2 2 0 +ERBB4 HER4 EC 2.7.10.1; KINASE; Kinase, protein; Membrane protein, integral; Protein kinase, TK; Protein kinase, tyrosine (receptor) Q15303 2066 2q34 human Y1258-p 451685 STLQHPDyLQEYSTK molecular association, regulation SHC1(INDUCES) 18721752 0 2 2 +Trpm8 TRPM8 Channel, cation; Membrane protein, integral; Membrane protein, multi-pass Q8R455 171384 9q35 rat Y1022-p 1877492902 FVVFAYFyMVVKKCF molecular association, regulation; ubiquitination; phosphorylation carcinogenesis, induced; cell motility, induced; cell growth, induced 14-3-3 zeta(INDUCES); TRPM8(INDUCES) 35665750 1 1 0 modulates LCK ubiquitination and phosphorylation +CLK2 CLK2 EC 2.7.12.1; KINASE; Kinase, protein; Protein kinase, CMGC; Protein kinase, dual-specificity (non-receptor) P49760 1196 1q22 human T127-p 15339202 RRRRRSRtFSRSSSQ apoptosis, altered; cell growth, altered 20682768 1 0 0 +IQCB1 IQCB1 Cell development/differentiation Q15051 9657 3q13.33|3q21.1 human K396-ub 95155304 KSALIIQkHWRGYRE IQ intracellular localization cell cycle regulation; cytoskeletal reorganization 28498859 1 1 0 regulation of cilia formation +MAP4 MAP4 Cytoskeletal; Motility/polarity/chemotaxis P27816 4134 3p21.31 human K847-ac 6216716 EGKPAEVkKMTAKSV cytoskeletal reorganization 28002468 1 2 3 +Kcnb1 Kv2.1 Channel, cation; Channel, ligand-gated; Channel, potassium; Membrane protein, integral; Membrane protein, multi-pass P15387 25736 3q42 rat Y690-p 22874701 LLPSLGLyHDPLRNR intracellular localization 22106938 2 2 2 regulates intracellular trafficking of Kv2.1 +Esrp2 RBM35B RNA-binding Q8K0G8 77411 8|8 D3 mouse K418-ub 52473101 RHKGMLGkRYIELFR carcinogenesis, inhibited; RNA splicing, induced; cell growth, inhibited 26522722 1 0 0 +RPL11 RPL11 Motility/polarity/chemotaxis; Nucleolus; Ribosomal; Translation P62913 6135 1p36.11 human K154-ne 12067607 RTGCIGAkHRISKEE Ribosomal_L5_C protein stabilization; intracellular localization 19713960 1 0 0 +PLEKHG1 PLEKHG1 GEF; GEF, Rac/Rho Q9ULL1 57480 6q25.1 human Y742-p 1876191900 QAVEENIyDTIGLPD activity, induced; molecular association, regulation; intracellular localization transcription, induced; cytoskeletal reorganization Fyn(INDUCES) 35031323 1 0 0 +SHC1 SHC1 iso2 Adaptor/scaffold; Apoptosis; Mitochondrial; Motility/polarity/chemotaxis P29353-2 6464 1q21.3 human Y448-p 33664400 SVSHLISyHMDNHLP SH2 molecular association, regulation JAK3(INDUCES) 24795043 1 0 0 +ATP2B2 ATP2B2 Cell development/differentiation; EC 3.6.3.8; Endoplasmic reticulum; Hydrolase; Membrane protein, integral; Membrane protein, multi-pass; Transporter; Transporter, ion channel Q01814 491 3p25.3 human T1139-p 11422300 RGLNRIQtQIRVVKA ATP_Ca_trans_C enzymatic activity, induced 1827443 1 0 0 effect (activation vs. inhibition) depends on PKC isozyme and lipid associated with ATP2B2 +Pacsin1 PACSIN1 Adaptor/scaffold Q61644 23969 17|17 A3.3 mouse T181-p 3827765 SKTEQSVtPEQQKKL molecular association, regulation; protein processing cytoskeletal reorganization; cell growth, altered 22355135 1 7 6 regulates lipid binding +NKAP NKAP Unknown function Q8N5F7 79576 Xq24 human S149-p 449164 APEVWGLsPKNPEPD NKAP intracellular localization transcription, induced; signaling pathway regulation 31461649 1 80 1 enhances NF-KB nuclear localization, regulates PTEN/NKAP/NF-KB/PDHK1 signaling +DSN1 DSN1 Cell cycle regulation Q9H410 79980 20q11.23 human S28-p 460419 HDHQLESsLSPVEVF intracellular localization 25660545 1 10 0 localization to G1 and G2 kinetochores +WWP2 WWP2 EC 6.3.2.-; EC 6.3.2.19; Ligase; UBIQUITIN LIGASE; Ubiquitin conjugating system; Ubiquitin ligase O00308 11060 16q22.1 human K473-sm 62489905 NTRTTTFkDPRPGFE WW molecular association, regulation PTEN(INDUCES) 27852060 1 0 0 +SCAMP3 SCAMP3 Membrane protein, integral; Membrane protein, multi-pass; Vesicle O14828 10067 1q22 human Y86-p 455165 EPKNYGSySTQASAA molecular association, regulation; phosphorylation cell cycle regulation; carcinogenesis, inhibited; cell growth, inhibited EGFR(INDUCES) 33850265 1 9 100 induces EGFR degradation, inhibits ERK phosphorylation +Aicda AID EC 3.5.4.38; Hydrolase Q9WVE0 11628 6|6 F1 mouse S38-p 457604 YVVKRRDsATSCSLD APOBEC2 molecular association, regulation; intracellular localization; enzymatic activity, induced DNA repair, induced; chromatin organization, altered; DNA repair, inhibited RPA1(INDUCES) DNA(INDUCES) 16251902; 16723391; 17911613; 18951095; 21113164; 36603026 12 3 0 +Rbbp8 CtIP EC 3.1.-.-; Transcription, coactivator/corepressor Q80YR6 225182 18|18 A1 mouse T855-p 27427901 WEVGFPStQTCLERG SAE2 phosphorylation cell cycle regulation; carcinogenesis, induced; DNA repair, induced; cell growth, inhibited; cell growth, induced; transcription, inhibited; signaling pathway regulation 31097467; 32989150; 34521752; 36640339 6 1 0 +KDR VEGFR2 EC 2.7.10.1; KINASE; Kinase, protein; Membrane protein, integral; Protein kinase, TK; Protein kinase, tyrosine (receptor) P35968 3791 4q12 human S229-p 56790201 RIYDVVLsPSHGIEL Ig_3 receptor internalization, inhibited cell motility, induced; cell adhesion, altered 27438154 1 0 0 mediates cell invasion and migration +ARHGEF7 ARHGEF7 GEF; GEF, Rac/Rho; Motility/polarity/chemotaxis Q14155 8874 13q34 human S761-p 14569926 DSLGRRSsLSRLEPS exocytosis, induced 25009260 1 2 0 dopamine release +Polr2a POLR2A EC 2.7.7.48; EC 2.7.7.6; Nucleotide Metabolism - purine; Nucleotide Metabolism - pyrimidine; Transcription initiation complex; Transferase P08775 20020 11 B3|11 42.86 cM mouse K1866-ub 2134724 KYSPTSPkYSPTSPK RNA_pol_Rpb1_R protein degradation 17526739 1 1 0 +Bad BAD Apoptosis O35147 64639 1q43 rat S112-p 5209400 METRSRHsSYPAGTE Bcl-2_BAD apoptosis, inhibited 33603838 2 9 71 increased cell viability +Aqp2 AQP2 Channel, misc.; Membrane protein, integral; Membrane protein, multi-pass; Transporter; Transporter, aquaporin family P34080 25386 7q36 rat S264-p 2238600 VELHSPQsLPRGSKA ubiquitination; intracellular localization; activity, inhibited exocytosis, induced; endocytosis, inhibited 18287043; 26147297; 27488997; 32113684 20 8 0 +MYCN N-Myc DNA-binding; Oncoprotein; Transcription factor P04198 4613 2p24.3 human R65-me 59175205 TPPLSPSrGFAEHSS Myc_N protein stabilization 27571165 1 0 0 +CALM1 Calmodulin Calcium-binding; Protein phosphatase, regulatory subunit P0DP23 801 14q32.11 human T118-p 469586 TNLGEKLtDEEVDEM EF-hand_7 protein conformation 26675311 4 1 0 +Aqp2 AQP2 Channel, misc.; Membrane protein, integral; Membrane protein, multi-pass; Transporter; Transporter, aquaporin family P34080 25386 7q36 rat K270-ub 999601 QSLPRGSkA______ intracellular localization 21148409 6 0 0 +Gsk3b GSK3B EC 2.7.11.1; EC 2.7.11.26; KINASE; Kinase, protein; Protein kinase, CMGC; Protein kinase, Ser/Thr (non-receptor) P18266 84027 11q21 rat Y216-p 448569 RGEPNVSyICSRYYR Pkinase enzymatic activity, induced apoptosis, induced 10995469; 36371197; 8382613 98 128 4206 +ACE2 ACE2 EC 3.4.17.23; Membrane protein, integral; Protease Q9BYF1 59272 Xp22.2 human K31-me 1881568100 QAKTFLDkFNHEAED Peptidase_M2 molecular association, regulation Spike Glycoprotein(DISRUPTS) 34031383 1 0 0 ACE2 peptide inhibitors, inhibit spike complexes at the cell surface, signi?cantly reduced SARS-CoV-2 spike protein at the cell surface and intracellularly in infected cells +FKBP5 FKBP5 Chaperone; EC 5.2.1.8; Isomerase Q13451 2289 6p21.31 human Y54-p 456461 PMIGDKVyVHYKGKL FKBP_C protein degradation; molecular association, regulation; ubiquitination; activity, inhibited carcinogenesis, induced; autophagy, inhibited; signaling pathway regulation PHLPP(DISRUPTS) 34077419 1 3 11 induces AKT phosphorylation, regulates FKBP51-AKT-Beclin 1 pathway +BARD1 BARD1 EC 6.3.2.-; EC 6.3.2.19; Ligase; UBIQUITIN LIGASE; Ubiquitin conjugating system; Ubiquitin ligase Q99728 580 2q35 human T714-p 465470 PKPDSDVtQTINTVA RNA stability, altered 16651405 1 0 1 inhibits mRNA processing +DNER DNER Membrane protein, integral; Receptor, misc. Q8NFT8 92737 2q36.3 human Y681-p 473322 RPAYEEFyNCRSIDS DNER_C intracellular localization 18474614 1 0 2 +Rac1 RAC1 G protein; G protein, monomeric; G protein, monomeric, Rho; Motility/polarity/chemotaxis P63001 19353 5 G2|5 82.22 cM mouse K147-ub 2142500 PQGLAMAkEIGAVKY Ras protein degradation cell motility, inhibited 22117219 3 12 26 regulates epithelial?mesenchymal transition (EMT) +CAMK4 CAMK4 EC 2.7.11.17; KINASE; Kinase, protein; Protein kinase, CAMK; Protein kinase, Ser/Thr (non-receptor) Q16566 814 5q22.1 human T57-gl 7780007 SELGRGAtSIVYRCK Pkinase phosphorylation 19506079 1 1 0 reduce phosphorylation at CAMK4-T200 +Pak3 PAK3 EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, STE; Protein kinase, Ser/Thr (non-receptor) Q62829 29433 Xq33 rat S139-p 448123 VNNQKYMsFTSGDKS enzymatic activity, induced 11278486 5 5 0 +BCL2 Bcl-2 Apoptosis; Autophagy; Membrane protein, integral; Oncoprotein P10415 596 18q21.33 human T56-p 448655 FSSQPGHtPHPAASR molecular association, regulation; protein stabilization; ubiquitination cell cycle regulation; apoptosis, altered; apoptosis, induced; apoptosis, inhibited PPP1CA(INDUCES); CDK1(INDUCES); NCL(INDUCES) 10669763; 10766756; 11077443; 11495898; 12039864; 15876860; 16714293; 18794113; 19336399 12 1 0 phosphorylation induced by viral infection +MAST1 MAST1 EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, AGC; Protein kinase, Ser/Thr (non-receptor) Q9Y2H9 22983 19p13.13 human K545-ub 573791192 DAREFLDkQVCGTPE Pkinase protein degradation 31449053 1 2 0 proteasomal degradation sensitizes cisplatin-resistant cells to cisplatin +Marcksl1 MLP Cell cycle regulation P28667 17357 4 D2.2|4 63.26 cM mouse S104-p 465848 PFKLSGLsFKRNRKE MARCKS intracellular localization cytoskeletal reorganization 21602810 1 74 60 +Scnn1g ENaC-gamma Channel, sodium; Membrane protein, integral; Membrane protein, multi-pass; Transporter, ion channel P37091 24768 1q36 rat T599-p 2228601 QDNPALDtDDDLPTF activity, induced; intracellular localization 18308722 1 0 0 membrane expression of ENAC beta and gamma, and may translocate CK2 to the cell membrane.; channel activation +VDAC1 VDAC1 Channel, misc.; Membrane protein, integral; Mitochondrial P21796 7416 5q31.1 human S104-p 452268 LTFDSSFsPNTGKKN Porin_3; TM protein stabilization apoptosis, induced 18381814 2 84 0 +SMAD2 SMAD2 DNA-binding; Transcription factor Q15796 4087 18q21.1 human S464-p 447567 GSPSVRCsSMS____ activity, induced; intracellular localization transcription, induced; transcription, altered SMAD4(INDUCES) 11043574; 8980228 5 1 1 +NBN NBS1 Cell cycle regulation; DNA repair, damage O60934 4683 8q21.3 human S432-p 483547 RIPNYQLsPTKLPSI molecular association, regulation; intracellular localization cell cycle regulation; chromatin organization, altered; DNA repair, altered; apoptosis, inhibited TRF2(DISRUPTS) 22927831; 28216226 4 40 0 radioprotective effects; recruitment of Apollo/SNM1B to leading strand telomeres, regulates telomere repair choice +Mcm2 MCM2 DNA-binding; EC 3.6.4.12 P97310 17216 6|6 D1 mouse S40-p 452311 RRADALTsSPGRDLP cell cycle regulation; DNA repair, inhibited 31488723; 35508654 12 29 18 +ACTL6A BAF53A O96019 86 3q26.33 human S86-p 18908932 RENMEAIsPLKNGMV Actin molecular association, regulation apoptosis, induced; transcription, induced RASSF6(INDUCES) 34898277 1 7 1 +MIEN1 MIEN1 Apoptosis; Motility/polarity/chemotaxis Q9BRT3 84299 17q12 human Y50-p 48921820 ASAVKEQyPGIEIES Rdx carcinogenesis, induced; cell motility, induced 26272794 1 0 0 +Spag5 SPAG5 Cell cycle regulation Q7TME2 54141 11 B5|11 46.74 cM mouse S66-p 460412 KERCNNSsPVDFINT cell cycle regulation 19806032 1 9 1 T24/66/447A mutant impairs meiosis progression +SUGT1 SUGT1 Cell cycle regulation; Ubiquitin conjugating system Q9Y2Z0 10910 13q14.3 human S331-p 18016406 VKRAMNKsFMESGGT SGS molecular association, regulation; intracellular localization cell cycle regulation; cytoskeletal reorganization HSP90A(INDUCES); DSN1(INDUCES) 21864708; 22869522 2 6 2 localization at kinetetchore; mitotic progression; association with MIS12 complex; kinetochore-microtubule attachments +Syn3 SYN3 Vesicle O70441 29130 7q13 rat S404-p 482763 VPGASVPsPLRPWGP cell motility, induced 25843720 1 5 0 neuronal migration and orientation +KAT5 Tip60 ACETYLTRANSFERASE; Acetyltransferase; EC 2.3.1.48; Nuclear receptor co-regulator; Nucleolus Q92993 10524 11q13.1 human S199-p 4759900 CLGTDEDsQDSSDGI protein stabilization; acetylation; enzymatic activity, induced 36280132 1 16 13 induces autoacetylation, delays degradation +WASF3 WASF3 Actin-binding; Motility/polarity/chemotaxis Q9UPY6 10810 13q12.13 human Y248-p 486449 HASDVTDySYPATPN cell motility, induced; cytoskeletal reorganization 17623672 1 1 1 induces lamellipodia formation +GATA3 GATA3 Transcription factor P23771 2625 10p14 human K304-ac 460635 NRPLIKPkRRLSAAR intracellular localization cell growth, inhibited; transcription, induced 10970860 1 0 0 regulated survival after activation, regulates T-cell trafficking to secondary +RUVBL1 RUVBL1 EC 3.6.4.12; Helicase; Motility/polarity/chemotaxis Q9Y265 8607 3q21.3 human R205-m2 63128908 GAVKRQGrCDTYATE TIP49 DNA repair, induced 28238654 1 1 0 +MAVS MAVS Adaptor/scaffold; Membrane protein, integral Q7Z434 57506 20p13 human K362-ub 12302372 RAGMVPSkVPTSMVL protein degradation 20483786; 31270229 2 1 1 +FLRT1 FLRT1 Cell adhesion; Membrane protein, integral; Motility/polarity/chemotaxis Q9NZU1 23769 11q13.1 human Y633-p 14150100 PYRAKEEyVVHTIFP intracellular localization cell growth, altered 20421966 1 0 0 regulates ERK1/2 activation +EGFR EGFR EC 2.7.10.1; KINASE; Kinase, protein; Membrane protein, integral; Oncoprotein; Protein kinase, TK; Protein kinase, tyrosine (receptor) P00533 1956 7p11.2 human S695-p 451484 LVEPLTPsGEAPNQA receptor internalization, altered carcinogenesis, induced; cell motility, induced 2115882; 35000271; 7505275 5 11 3 +Ppara PPAR-alpha DNA-binding; Nuclear receptor; UBIQUITIN LIGASE P23204 19013 15 E2|15 40.42 cM mouse S73-p 59026900 SVITDTLsPASSPSS protein degradation; ubiquitination; activity, inhibited transcription, inhibited 27738106; 28096081 2 0 0 +Neurog1 neurogenin 1 Cell development/differentiation; DNA-binding; Transcription factor P70660 18014 13 B1|13 30.06 cM mouse T130-p 1186000 FPDDTKLtKIETLRF HLH protein stabilization; molecular association, regulation E2A(NOT_REPORTED) 17623011 1 0 0 frog (Xenopus) E2A +NSF NSF Adaptor/scaffold; Autophagy; EC 3.6.4.6; Protease; Vesicle P46459 4905 17q21.31 human Y83-p 453414 QEIEVSLyTFDKAKQ CDC48_N molecular association, regulation; enzymatic activity, inhibited; enzymatic activity, induced exocytosis, inhibited SNAP-alpha(DISRUPTS); PTP1B(INDUCES) 15322554; 31194868 2 1 0 +Adrb2 ADRB2 GPCR, family 1; Membrane protein, integral; Membrane protein, multi-pass; Receptor, GPCR P04274 101836719 hamster S261-p 447908 SGHGLRRsSKFCLKE 7tm_1 receptor desensitization, altered 8083204 9 2 0 S262 was primary site of cAPK desensitization, while either 261 or 262 for PKC desensitization, as well as ADRB2 expression level. +CCDC88A girdin Actin-binding Q3V6T2 55704 2p16.1 human Y1765-p 450761 PRKTEDTyFISSAGK molecular association, regulation; phosphorylation carcinogenesis, induced; exocytosis, induced; cell motility, induced; cytoskeletal reorganization; signaling pathway regulation PIK3R1(INDUCES) 21954290; 26887938; 36822326 4 14 36 induces Nephrin and AKT phosphorylation, induces PI3K/Akt signaling +TCF3 E2A Cell development/differentiation; DNA-binding; Oncoprotein; Transcription factor P15923 6929 19p13.3 human S341-p 10359100 KALASIYsPDHSSNN activity, inhibited transcription, inhibited 19801649 1 1 4 +EDNRA EDNRA GPCR, family 1; Membrane protein, integral; Membrane protein, multi-pass; Motility/polarity/chemotaxis; Receptor, GPCR P25101 1909 4q31.22-q31.23 human S421-p 2911708 NHNTDRSsHKDSMN_ receptor desensitization, induced 24064210 1 1 0 Lack of S397, T403 and S404 influences desensitization to a greater extent compared than S391, S393, and T396 +SH3RF1 SH3RF1 Adaptor/scaffold; EC 6.3.2.-; EC 6.3.2.19; Ligase; UBIQUITIN LIGASE; Ubiquitin conjugating system; Ubiquitin ligase Q7Z6J0 57630 4q32.3-q33 human S304-p 482847 KNTKKRHsFTSLTMA molecular association, regulation apoptosis, inhibited RAC1(INDUCES) 17535800 2 18 22 +Foxo6 FOXO6 DNA-binding Q70KY4 329934 4|4 D2.1 mouse T26-p 2899101 QSRPRSCtWPLPQPD intracellular localization transcription, inhibited 12857750; 15987244 2 0 0 Mediates growth factor sensitivity and inhibition transcriptional activity independent of translocation. ; nuclear export +FFAR4 GPR120 iso1 GPCR, family 1; Lipid-binding; Membrane protein, integral; Membrane protein, multi-pass; Receptor, GPCR Q5NUL3-1 338557 10q23.33 human T363-p 31014807 PEKGAILtDTSVKRN receptor internalization, induced; molecular association, regulation ARR3(INDUCES); ARRB1(INDUCES) 24412271; 24817122 5 1 0 +COPS6 COPS6 Cell cycle regulation Q7L5N1 10980 7q22.1 human S148-p 48903200 QVCEIIEsPLFLKLN JAB protein stabilization carcinogenesis, induced; cell motility, induced; cell growth, induced 26267535 1 0 0 +OPRL1 KOR-3 GPCR, family 1; Membrane protein, integral; Membrane protein, multi-pass; Receptor, GPCR P41146 4987 20q13.33 human T362-p 1868135702 DVALACKtSETVPRP receptor internalization, induced; receptor desensitization, induced signaling pathway regulation 30914485 2 0 0 +SMAD5 SMAD5 DNA-binding; Transcription, coactivator/corepressor Q99717 4090 5q31.1 human S465-p 448456 LNPISSVs_______ cell growth, inhibited; transcription, induced 35573984 7 18 41 +MAPK14 P38A EC 2.7.11.24; KINASE; Kinase, protein; Protein kinase, CMGC; Protein kinase, Ser/Thr (non-receptor) Q16539 1432 6p21.31 human K152-ac 18575505 DIIHRDLkPSNLAVN Pkinase molecular association, regulation; phosphorylation; enzymatic activity, induced apoptosis, induced Other(INDUCES) 21444723 1 1 0 induces ATP binding, induces phosphorylation of ATF2 +CDT1 CDT1 DNA replication; DNA-binding; Motility/polarity/chemotaxis; Oncoprotein Q9H211 81620 16q24.3 human T7-p 1239966005 _MEQRRVtDFFARRR cell cycle regulation; cytoskeletal reorganization 30154187 1 1 0 regulates kTM stability +VIM Vimentin Cytoskeletal; Motility/polarity/chemotaxis P08670 7431 10p13 human S7-p 455449 _MSTRSVsSSSYRRM Filament_head cell motility, altered 19291697 8 21 1 +TP53 p53 Activator; DNA-binding; Motility/polarity/chemotaxis; Nuclear receptor co-regulator; Transcription factor; Tumor suppressor P04637 7157 17p13.1 human S215-p 454242 DRNTFRHsVVVPYEP P53 protein degradation; molecular association, regulation; protein stabilization; ubiquitination; protein conformation; activity, inhibited cell cycle regulation; carcinogenesis, induced; cell motility, inhibited; transcription, induced; transcription, altered; apoptosis, inhibited; transcription, inhibited; cell growth, altered DNA(DISRUPTS) 15469940; 20847049; 22611192; 25691063; 27496712 6 0 0 +IRF7 IRF7 DNA-binding; Transcription factor Q92985 3665 11p15.5 human S483-p 486437 SSLSLCLsSANSLYD transcription, inhibited 10893229 3 0 0 +TNS3 tensin 3 Adaptor/scaffold; Motility/polarity/chemotaxis Q68CZ2 64759 7p12.3 human Y1256-p 462739 KGCSNEPyFGSLTAL SH2 molecular association, regulation cell motility, altered; cell growth, altered P130Cas(INDUCES); KHDRBS1(INDUCES); FAK(INDUCES) 19732724 1 1 17 contributes to tumorigenesis and metastasis +Camk2b CAMK2B EC 2.7.11.17; KINASE; Kinase, protein; Protein kinase, CAMK; Protein kinase, Ser/Thr (non-receptor) P28652 12323 11 A1|11 3.89 cM mouse T287-p 450048 SMMHRQEtVECLKKF phosphorylation; enzymatic activity, induced cell cycle regulation; cell growth, induced; signaling pathway regulation 15944130; 19004831; 33755308; 34088288 32 17 109 CaMKII/c-Myc/CDK6 pathway; induces phosphorylation of RYR2 further modulating cardiac function +CRYAB CRYAB Chaperone; Heat shock protein P02511 1410 11q23.1 human S45-p 448748 FPTSTSLsPFYLRPP Crystallin activity, induced; protein degradation; molecular association, regulation; intracellular localization; activity, inhibited; protein conformation exocytosis, inhibited; apoptosis, inhibited FBXO4(INDUCES); CASP7(INDUCES); CRYAB(DISRUPTS); CASP3(INDUCES); GEMIN3(INDUCES); CASP2(DISRUPTS) 11096101; 12468532; 15117944; 15511225; 16129694; 16928191; 18061612; 23049853; 24023879; 26620801; 27641668 35 7 1 +PFKFB2 PFKFB2 Carbohydrate Metabolism - fructose and mannose; EC 2.7.1.105; EC 3.1.3.46; Kinase, other; Motility/polarity/chemotaxis; Phosphatase (non-protein) P26285 287019 cow S467-p 448460 PVRMRRNsFTPLSSS molecular association, regulation; enzymatic activity, induced Other(INDUCES) 2846551; 9211863 10 60 333 +EEF2 EEF2 Translation; Translation elongation P55823 rabbit T58-p 450254 GETRFTDtRKDEQER GTP_EFTU activity, inhibited 8386634 5 30 31 +YWHAZ 14-3-3 zeta Adaptor/scaffold; Motility/polarity/chemotaxis P63104 7534 8q22.3 human S184-p 449855 FYYEILNsPEKACSL 14-3-3 protein stabilization; molecular association, regulation; protein conformation; phosphorylation HSP20(INDUCES); JNK1(NOT_REPORTED); BAX(DISRUPTS) 15071501; 16009721; 18559254; 21081103 7 4 0 +Gabbr2 GABBR2 GPCR, family 3; Membrane protein, integral; Membrane protein, multi-pass; Receptor, GPCR O88871 83633 5q22 rat S783-p 473060 VTSVNQAsTSRLEGL GBR2_CC activity, induced; intracellular localization signaling pathway regulation 17224405; 20643948; 27498877 10 0 0 regulates postendocytic sorting of GABA receptors; decreases attenuation of receptor activation; accumulating GABBR2 at presynaptic terminals; promotes neuronal survival after ischemia +DDX39A DDX39 EC 3.6.4.13; Helicase; RNA splicing; RNA-binding O00148 10212 19p13.12 human K52-sm 1876998412 GFRDFLLkPELLRAI molecular association, regulation RNA(DISRUPTS) 32393512 1 1 0 +FGFBP1 FGFBP1 Q9MZ06 281812 cow S36-p 487543 NRRGSKAsADESLAL FGF-BP1 molecular association, regulation FGF1(DISRUPTS) 17560725 1 0 0 +DSN1 DSN1 Cell cycle regulation Q9H410 79980 20q11.23 human S100-p 480153 RQSWRRAsMKETNRR MIS13 molecular association, regulation; intracellular localization MIS12(INDUCES); CENPC1(INDUCES) 18640974; 25601404; 25660545; 27881301; 34758321 7 4 5 +NCL NCL DNA-binding; Helicase; Nuclear receptor co-regulator; Nucleolus; RNA-binding P19338 4691 2q37.1 human T707-p 21697921 HKPQGKKtKFE____ molecular association, regulation; protein stabilization carcinogenesis, induced; cell growth, induced; RNA stability, induced; translation, induced RNA(INDUCES) 21998300; 25173817 2 0 0 induces binding to Sp1 RNA and IRES-mediated Sp1 expression +Kcna2 Kv1.2 Channel, potassium; Membrane protein, integral; Membrane protein, multi-pass P63142 25468 2q34 rat S440-p 1818100 TSCPKIPsSPDLKKS intracellular localization 18056633 1 7 0 +PARK7 DJ-1 EC 3.4.-.-; Nuclear receptor co-regulator; Transcription regulation; Tumor suppressor Q99497 11315 1p36.23 human K130-sm 2407414 VTTHPLAkDKMMNGG DJ-1_PfpI molecular association, regulation; intracellular localization cell growth, induced; apoptosis, induced; apoptosis, inhibited; transcription, inhibited PIAS1(DISRUPTS) 11477070; 15976810; 18339323 4 0 0 +Ppargc1b PGC-1 beta Nuclear receptor co-regulator; Transcription, coactivator/corepressor Q8VHJ7 170826 18|18 E1 mouse K645-ac 7761206 ATPGASHkLPKRHPE intracellular localization transcription, inhibited 19491097 1 1 0 +FER Fer EC 2.7.10.2; KINASE; Kinase, protein; Oncoprotein; Protein kinase, TK; Protein kinase, tyrosine (non-receptor) P16591 2241 5q21.3 human Y714-p 448461 RQEDGGVySSSGLKQ PK_Tyr_Ser-Thr enzymatic activity, induced 19159681 3 34 611 +KIR3DL1 KIR3DL1 Membrane protein, integral; Receptor, misc. P43629 3811 19q13.42 human S388-p 990303 RTANSEDsDEQDPEE activity, induced; receptor internalization, altered 17911614 1 0 0 +PPP6R2 SAPS2 Unknown function O75170 9701 22q13.33 human S771-p 4764365 ESGPRCSsPVDTECS molecular association, regulation cell cycle regulation PLK1(INDUCES) 29764989 1 14 1 +UBA1 UBE1 EC 6.3.2.19; UBIQUITIN LIGASE; Ubiquitin conjugating system; Ubiquitin ligase P22314 7317 Xp11.3 human K604-ub 3934846 ESGTLGTkGNVQVVI ThiF enzymatic activity, induced 33355669 1 7 31 inhibition of viral DNA replication and virus production +RRAS RRas G protein; G protein, monomeric; G protein, monomeric, Ras; Motility/polarity/chemotaxis P10301 6237 19q13.33 human S201-p 18015221 QEQELPPsPPSAPRK activity, induced 27086924 1 7 0 +PRKCE PKCE EC 2.7.11.13; KINASE; Kinase, protein; Protein kinase, AGC; Protein kinase, Ser/Thr (non-receptor) Q02156 5581 2p21 human S350-p 486055 RSKSAPTsPCDQEIK molecular association, regulation; intracellular localization; phosphorylation cell cycle regulation 14-3-3 zeta(DISRUPTS) 18604201; 34143863 2 10 0 C1A and C1B domains are necessary for localization, and inter-C1 domain (IC1D) domains for retention at the midbody, S350 dephosphorylation is necessary for 14-3-3 complex assembly, and for Aurora B S227 phosphorylation at the midbody +ARHGAP35 GRF-1 GAP; GAP, Rac/Rho; Motility/polarity/chemotaxis; Transcription factor; Tumor suppressor Q9NRY4 2909 19q13.32 human Y1105-p 448941 RNEEENIySVPHDST RhoGAP_pG1_pG2 activity, induced; molecular association, regulation cell motility, induced RASA1(INDUCES) 16513268; 30664792; 32540970 5 83 3224 +IKBKB IKKB EC 2.7.11.10; KINASE; Kinase, protein; Protein kinase, Other; Protein kinase, Ser/Thr (non-receptor) O14920 3551 8p11.21 human S181-p 447489 DQGSLCTsFVGTLQY Pkinase activity, induced; molecular association, regulation; protein stabilization; ubiquitination; intracellular localization; phosphorylation; enzymatic activity, induced carcinogenesis, induced; cell growth, induced; cell motility, altered; transcription, induced; transcription, inhibited; transcription, altered; signaling pathway regulation IKKA(INDUCES) 10195894; 11325957; 11460167; 16267042; 17150968; 18930133; 18950704; 19073147; 24833394; 35173553; 35339487; 35476515; 35525271; 9346484 76 2 0 NFkB pathway; induces IKB phosphorylation; regulates NFkB signaling; induces induces nuclear localization of p65, thus inducing the TNFa/NF-kB signaling pathway +RB1 Rb Nuclear receptor co-regulator; Oncoprotein; Transcription, coactivator/corepressor; Tumor suppressor P06400 5925 13q14.2 human K720-sm 3817003 KVKNIDLkFKIIVTA RB_B protein stabilization; molecular association, regulation cell growth, induced; transcription, inhibited lamin A/C(INDUCES) 15806172; 27270425 2 0 0 +FLI1 FLI1 DNA-binding; Oncoprotein; Transcription factor Q01543 2313 11q24.3 human K380-ac 6406003 PTESSMYkYPSDISY protein degradation; molecular association, regulation transcription, induced DNA(DISRUPTS) 17884818; 22973553; 24058639 3 1 0 +KLF10 KLF10 C2H2-type zinc finger protein; DNA-binding; Transcription factor Q13118 7071 8q22.3 human T445-p 20573500 FMRSDHLtKHARRHL zf-C2H2 intracellular localization transcription, induced 20953893 1 0 0 +PRKAA1 AMPKA1 Autophagy; EC 2.7.11.1; EC 2.7.11.26; EC 2.7.11.27; EC 2.7.11.31; KINASE; Kinase, protein; Protein kinase, CAMK; Protein kinase, Ser/Thr (non-receptor) Q13131 5562 5p13.1 human K71-ub 964497636 RSLDVVGkIRREIQN Pkinase enzymatic activity, inhibited 31996460 1 1 0 +HDAC6 HDAC6 DEACETYLASE; Deacetylase; EC 3.5.1.98; Nuclear receptor co-regulator; Ubiquitin conjugating system Q9UBN7 10013 Xp11.23 human S458-p 18944908 EEDNVEEsEEEGPWE molecular association, regulation; intracellular localization autophagy, induced; chromatin organization, altered; apoptosis, inhibited; cytoskeletal reorganization DNAH1(INDUCES) 21486957 1 1 0 chromatin condensation, induces tubulin deacetylation and increase aggresomes +SIRPA SHPS1 Cell adhesion; Cell surface; Membrane protein, integral; Motility/polarity/chemotaxis; Receptor, misc. P78324 140885 20p13 human Y496-p 451115 PEPSFSEyASVQVPR molecular association, regulation; phosphorylation cell motility, induced; cell growth, induced; signaling pathway regulation CTK(INDUCES); SHP-2(INDUCES); SHP-1(INDUCES) 10842184; 18233962; 21799000 5 16 136 regulation TLR3/4-dependent cytokine production pathway; Mutation of these 4 tyrosines does not affect JAK2 binding. However, overexpression of the WT SHPS1 but not the 4 tyrosine to phenylalanine mutation reduces tyrosine phosphorylation of Jak2, STAT5B, and STAT3 and activation of Erk1/2 in response to growth hormone. Does not affect STAT3 tyrosine phosphorylation in response to LIF agonist.; induces phosphorylation of itself at Y429 and Y453, and of MAPK, regulates SHPS1- signaling +EIF6 EIF6 Nucleolus; Translation; Translation initiation P56537 3692 20q11.22 human S239-p 3193264 IATSMRDsLIDSLT_ intracellular localization translation, altered 32703900 1 10 0 +Sh3pxd2a Tks5 Adaptor/scaffold O89032 14218 19|19 C3 mouse Y557-p 458193 VKYEEPEyDVPAFGF molecular association, regulation cell cycle regulation; cell motility, altered; cytoskeletal reorganization NCK1(INDUCES); NCK2(INDUCES); WASP(INDUCES) 18515860; 19596797 1 4 11 +NPM/ALK NPM-ALK KINASE; Kinase, protein; Protein kinase, TK; Protein kinase, tyrosine (receptor) AAA58698 human Y343-p 27275115 DIYRASYyRKGGCAM PK_Tyr_Ser-Thr molecular association, regulation; enzymatic activity, induced carcinogenesis, altered VAV3(INDUCES); SHP-1(INDUCES) 17998938; 19887368; 20424160 4 2 3 SHP1 phosphatase mediates tyrosine dephosphorylation of ALK +MAPK3 ERK1 EC 2.7.11.24; KINASE; Kinase, protein; Protein kinase, CMGC; Protein kinase, Ser/Thr (non-receptor) P27361 5595 16p11.2 human Y204-p 447543 HTGFLTEyVATRWYR Pkinase activity, induced; protein degradation; molecular association, regulation; intracellular localization; protein conformation; phosphorylation; enzymatic activity, induced cell cycle regulation; carcinogenesis, induced; apoptosis, altered; apoptosis, induced; cell motility, induced; cell motility, inhibited; signaling pathway regulation; cell growth, induced; cell motility, altered; transcription, inhibited; cell growth, altered; cell differentiation, inhibited; carcinogenesis, inhibited; cell growth, inhibited; transcription, induced; transcription, altered; autophagy, induced; cell differentiation, induced; apoptosis, inhibited; autophagy, inhibited; cytoskeletal reorganization TACE(INDUCES); ERK2(INDUCES); leupaxin(NOT_REPORTED); GSK3B(INDUCES); KSR(INDUCES) 10597231; 10925301; 11352917; 12368275; 12609989; 12808105; 12917346; 12952943; 15004239; 15059947; 16149052; 16397900; 16585161; 17562849; 17667937; 17685427; 18042541; 18045996; 18519681; 18658095; 18775330; 19088846; 19106095; 19144315; 20122898; 20228268; 20231899; 20868520; 21478863; 21530327; 21561860; 21685939; 21726627; 21730054; 21893193; 21917714; 21980390; 22385658; 23644655; 24632852; 25538243; 26073130; 26079947; 26586479; 27323830; 28574827; 30987999; 31722981; 31736979; 31933886; 32081857; 32107290; 33627405; 33667549; 33731431; 33820494; 33828192; 34017102; 34209868; 34226680; 34262144; 34380633; 34473994; 34480897; 34497368; 34588619; 34611296; 34611309; 34642304; 34675408; 34921013; 34992144; 35173310; 35293964; 35367211; 35414784; 35439648; 35544764; 36053753; 36216931; 36289618; 36346366; 36455198; 36509141; 36529291; 36966223; 37016335; 7535768; 8444886; 9124279 1366 142 3549 +MUTYH MUTYH DNA repair, damage; EC 3.2.2.-; Hydrolase; Mitochondrial; Tumor suppressor Q9UIF7 4595 1p34.1 human S535-p 15343401 NFFRSHIsTDAHSLN protein stabilization; enzymatic activity, induced 20724227 1 1 0 +Lime1 LIME1 Adaptor/scaffold; Membrane protein, integral Q9EQR5 72699 2|2 H4 mouse Y137-p 463651 STSSEATySNVGLAA LIME1 activity, induced GRB2(INDUCES) 16249387 2 0 2 +Trim28 TIF1B EC 6.3.2.-; KINASE; Kinase, protein; Ligase; Nuclear receptor co-regulator; Protein kinase, atypical; SUMO LIGASE; SUMO ligase; Transcription, coactivator/corepressor; UBIQUITIN LIGASE; Ubiquitin conjugating system; Ubiquitin ligase Q62318 21849 7|7 A1 mouse S824-p 460839 LPSAGLSsQELSGPG intracellular localization DNA repair, induced 22205726 47 9 6 +NOXO1 NOXO1 iso3 Adaptor/scaffold Q8NFA2-3 124056 16p13.3 human S154-p 27454492 SRAAGRLsIHSLEAQ molecular association, regulation; intracellular localization; protein conformation; enzymatic activity, induced GRB2(INDUCES); CYBA(INDUCES); NOXA1(INDUCES) 23322165; 26781991 3 4 0 EGF-dependent membrane translocation of NoxO1; required for optimal ROS production by NOX1 +NFKBIA IkB-alpha DNA-binding; Inhibitor P25963 4792 14q13.2 human K67-ub 15390764 PRGSEPWkQQLTEDG activity, induced; protein degradation 36229750 1 2 4 induced foam cell formation, pyroptosis, and in?ammation +Pnpla2 PNPLA2 EC 3.1.1.3; Lipase; Membrane protein, integral Q8BJ56 66853 7|7 F5 mouse T372-p 33673902 IRWMKEQtGSICQYL intracellular localization; enzymatic activity, inhibited 24801391 2 1 0 +ERBB2 HER2 EC 2.7.10.1; KINASE; Kinase, protein; Membrane protein, integral; Oncoprotein; Protein kinase, TK; Protein kinase, tyrosine (receptor) P04626 2064 17q12 human Y1196-p 448676 GAVENPEyLTPQGGA molecular association, regulation; phosphorylation; enzymatic activity, induced cell motility, altered; transcription, induced; signaling pathway regulation SHC1(INDUCES); CRK(INDUCES); SH3BGRL3(INDUCES); PAK1(INDUCES) 11238891; 16729043; 18332126; 19525980; 28842430 14 3 5 SLK activation, cell motility, leadiing to cancer cell invasion +Phlpp2 PHLPP2 EC 3.1.3.16; PHOSPHATASE; Protein phosphatase, Ser/Thr (non-receptor); Tumor suppressor Q8BXA7 244650 8|8 D3 mouse S1207-p 4754865 FGIRRQNsVNSGILL protein degradation; molecular association, regulation KCTD17(INDUCES) 28859855 1 22 6 +GAB1 GAB1 Adaptor/scaffold; Motility/polarity/chemotaxis Q13480 2549 4q31.21 human T387-p 4783368 MSPSRSNtISTVDLN cytoskeletal reorganization 22751113 1 6 0 +FOXO4 FOXO4 DNA-binding; Oncoprotein; Transcription factor P98177 4303 Xq13.1 human T227-p 15798100 PAPPEGAtPTSPVGH carcinogenesis, altered; transcription, altered 20959475 1 3 0 +CTBP1 CTBP1 Cell cycle regulation; EC 1.1.1.-; Nuclear receptor co-regulator; Oxidoreductase; Transcription, coactivator/corepressor Q13363 1487 4p16.3 human S158-p 455351 REGTRVQsVEQIREV 2-Hacid_dh; 2-Hacid_dh_C protein degradation; molecular association, regulation; ubiquitination; intracellular localization; enzymatic activity, inhibited transcription, induced; transcription, altered STF-1(DISRUPTS) 12872159; 18184656; 23291169 7 2 0 attenuates the repressive function of CtBP1 on Bax promoter +SMAD4 SMAD4 DNA-binding; Nuclear receptor co-regulator; Transcription, coactivator/corepressor Q13485 4089 18q21.2 human K159-sm 2793925 APSSMMVkDEYVHDF molecular association, regulation; protein stabilization; intracellular localization transcription, induced; transcription, inhibited; signaling pathway regulation DAXX(INDUCES) 12621041; 12740389; 14514699; 14750902; 15028714; 15637079 8 1 0 binding to DAXX induces DAXX recruitment to SMAD4 targeted promoter, further regulating TGF-beta signaling +ESR1 ER-alpha DNA-binding; Nuclear receptor; Transcription factor P03372 2099 6q25.1-q25.2 human K299-ac 459092 WPSPLMIkRSKKNSL protein stabilization cell growth, inhibited; cell motility, inhibited; transcription, induced 30787391; 33544437 4 3 0 MOF depletion promotes proliferation, motility and invasion in HCC +POLR2A POLR2A EC 2.7.7.48; EC 2.7.7.6; Nucleotide Metabolism - purine; Nucleotide Metabolism - pyrimidine; Transcription initiation complex; Transferase P24928 5430 17p13.1 human T1618-gl 6778600 QSPSYSPtSPSYSPT RNA_pol_Rpb1_R enzymatic activity, inhibited 11425311 2 0 0 glycosylation inhibits activity of CDK7 (CAK) +PLEC Plectin-1 Cytoskeletal; Motility/polarity/chemotaxis Q15149 5339 8q24.3 human S4642-p 3196844 RAGSRRGsFDATGSG molecular association, regulation; intracellular localization cytoskeletal reorganization K18(DISRUPTS); Vimentin(DISRUPTS); K14(DISRUPTS); desmin(DISRUPTS); NFH(DISRUPTS); K8(DISRUPTS); NFL(DISRUPTS); K5(DISRUPTS) 23843618 1 28 110 disrupts binding to intermediate filaments +MEF2A MEF2A DNA-binding; Motility/polarity/chemotaxis; Transcription factor Q02078 4205 15q26.3 human K403-ac 486379 TNQNISIkSEPISPP acetylation cell differentiation, inhibited; transcription, induced 16484498 1 0 0 switch from sumoylation to acetylsation +EZH2 EZH2 EC 2.1.1.43; METHYLTRANSFERASE; Methyltransferase; Methyltransferase, protein lysine Q15910 2146 7q36.1 human T367-p 466987 NNSSRPStPTINVLE molecular association, regulation; intracellular localization; enzymatic activity, induced carcinogenesis, induced; cell motility, induced; cell growth, inhibited; cell differentiation, induced; transcription, induced; cell motility, inhibited; transcription, inhibited YY1(INDUCES); P38A(INDUCES) 20887952; 27494834; 34685528; 35992062 5 21 45 induces p38 methylation and phosphorylation of p38 and AKT; inhibits H3 methylation; leads to nuclear localization through dephosphorylation of pT367; decreases H3K27 trimethylation +H2AC11 H2A.1 DNA-binding P0C0S8 8329 6p22.1 human K9-ac 480300 GRGKQGGkARAKAKT Histone transcription, altered 17560255 4 5 145 +RUNX3 AML2 DNA-binding; Transcription factor Q13761 864 1p36.11 human K94-ac 57676502 KTLPVAFkVVALGDV Runt molecular association, regulation apoptosis, induced; transcription, induced; signaling pathway regulation BRD2(INDUCES) 24229708 1 0 0 induces p14-p53 pathway +BAX BAX Apoptosis; Membrane protein, integral; Mitochondrial; Tumor suppressor Q07812 581 19q13.33 human S60-p 983100 DASTKKLsECLKRIG intracellular localization 17911107 1 0 0 +HNF4A HNF4 alpha DNA-binding; Nuclear receptor; Transcription factor P41235 3172 20q13.12 human K108-ac 460632 QCVVDKDkRNQCRYC zf-C4 molecular association, regulation; intracellular localization; protein conformation transcription, induced Exportin-1(DISRUPTS); CBP(INDUCES) DNA(INDUCES) 10882110 1 0 0 +Dpysl5 CRMP-5 Q9EQF6 65254 5|5 B1 mouse T509-p 478230 PGKKEMGtPLADTPT phosphorylation 29758318 1 11 1 S522A KI mice +DAXX DAXX Apoptosis; Nuclear receptor co-regulator; Nucleolus; Transcription, coactivator/corepressor Q9UER7 1616 6p21.32 human S739-p 467727 EIIVLSDsD______ sumoylation; molecular association, regulation apoptosis, altered; transcription, altered SUMO1(INDUCES); PML(INDUCES) 21474068 1 22 0 +Vim Vimentin Cytoskeletal; Motility/polarity/chemotaxis P20152 22352 2 A1|2 10.04 cM mouse S9-p 455450 STRSVSSsSYRRMFG Filament_head molecular association, regulation endocytosis, induced JAG1(INDUCES) 28533359 4 4 3 transendocytosis +APEX1 APE1 DNA repair, damage; DNA-binding; Deoxyribonuclease; EC 4.2.99.18; Endoplasmic reticulum; Hydrolase; Lyase; Nuclear receptor co-regulator; Nucleolus; Transcription, coactivator/corepressor P27695 328 14q11.2 human K35-ac 15207805 TAAKKNDkEAAGEGP molecular association, regulation; acetylation; intracellular localization; protein conformation; enzymatic activity, induced DNA repair, induced; cell growth, inhibited NPM1(DISRUPTS) RNA(DISRUPTS) 22918947 2 2 2 disrupts rRNA binding, induces acetylation at K6 and K7 +MAPT Tau iso8 ACETYLTRANSFERASE; Acetyltransferase; Cytoskeletal P10636-8 4137 17q21.31 human S356-gl 5227900 RVQSKIGsLDNITHV Tubulin-binding molecular association, regulation; protein conformation Tau iso8(DISRUPTS) 18671940 1 0 0 modulates aggregation of tau filaments +DNMT1 DNMT1 Amino Acid Metabolism - cysteine and methionine; Cell development/differentiation; EC 2.1.1.37; METHYLTRANSFERASE; Methyltransferase; Methyltransferase, DNA; Transcription regulation P26358 1786 19p13.2 human K1113-ac 466386 PGNKGKGkGKGKGKP cell cycle regulation; transcription, inhibited 21947282 1 4 2 +DYRK2 DYRK2 EC 2.7.12.1; KINASE; Kinase, protein; Protein kinase, CMGC; Protein kinase, dual-specificity (non-receptor) Q92630 8445 12q15 human S442-p 11489909 IELLGMPsQKLLDAS Pkinase enzymatic activity, induced apoptosis, altered 19965871 1 0 0 p53-mediated apoptosis +SUGT1 SUGT1 Cell cycle regulation; Ubiquitin conjugating system Q9Y2Z0 10910 13q14.3 human T265-p 455435 EGQGDVPtPKQFVAD protein stabilization; molecular association, regulation cell cycle regulation RNF41(INDUCES) 28696259 1 22 18 +LIMK1 LIMK1 EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, Ser/Thr (non-receptor); Protein kinase, TKL P53667 3984 7q11.23 human S307-p 3191869 DRSPGAGsLGSPASQ intracellular localization; enzymatic activity, induced cell cycle regulation; cytoskeletal reorganization 22214762 1 4 0 +CEBPB C/EBP-beta DNA-binding; Motility/polarity/chemotaxis; Transcription factor P17676 1051 20q13.13 human R3-m2 12626408 _____MQrLVAWDPA molecular association, regulation cell differentiation, inhibited; transcription, inhibited SMARCC1(DISRUPTS); MED23(DISRUPTS); SMARCB1(DISRUPTS); SMARCA2(DISRUPTS); MED26(DISRUPTS) 20111005 1 1 0 +Pdzd11 PDZD11 Adaptor/scaffold Q9CZG9 72621 X|X C3 mouse Y10-p 451588 NRIPYDDyPVVFLPA molecular association, regulation DECR1(INDUCES); ACAA2(INDUCES); TCERG1(INDUCES) 18268350 0 12 136 +DAPK2 DAPK2 EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, CAMK; Protein kinase, Ser/Thr (non-receptor) Q9UIK4 23604 15q22.31 human T369-p 487231 HPRRRSStS______ molecular association, regulation; phosphorylation 14-3-3 gamma(INDUCES); Calmodulin(DISRUPTS); DAPK2(INDUCES) 34413451 2 1 1 binding to 14-3-3 gamma induces DAPK2 dimerization, inhibits CaM-DAPK2 binding and DAPK2 dephosphorylation +SLC6A4 SERT Membrane protein, integral; Membrane protein, multi-pass; Transporter P31645 6532 17q11.2 human S48-p 1869992415 GQISNGYsAVPSPGA 5HT_transport_N receptor internalization, inhibited 32797733 1 0 0 +CORO7 coronin 7 Vesicle P57737 79585 16p13.3 human Y738-p 1871177707 PSTLLPSyDPDTGLV phosphorylation signaling pathway regulation 33162394 1 0 0 inhibits phosphorylation of YAP7 and hence the Hippo signaling pathway +TP53BP1 53BP1 DNA repair, damage; Transcription, coactivator/corepressor Q12888 7158 15q15.3 human T1609-p 486510 LGPYEAVtPLTKAAD activity, induced; molecular association, regulation; ubiquitination; intracellular localization cell cycle regulation; chromatin organization, altered; DNA repair, inhibited RNF168(DISRUPTS) 24703952 2 16 15 induce genome stability and Abrogates 53BP1 Foci in G1 Cells. Prevents the interaction of 53BP1 with chromatin. +Plcb1 PLCB1 Carbohydrate Metabolism - inositol phosphate; EC 3.1.4.11; Phospholipase P10687 24654 3q36 rat S887-p 450172 HSQPAPGsVKAPAKT activity, inhibited 11278470 3 1 0 +SET SET iso2 Apoptosis; DNA replication; DNA-binding; Inhibitor; Nuclear receptor co-regulator; Oncoprotein; Protein phosphatase, regulatory subunit Q01105-2 6418 9q34.11 human S9-p 6308300 SAPAAKVsKKELNSN receptor desensitization, induced; molecular association, regulation; intracellular localization; enzymatic activity, inhibited; phosphorylation signaling pathway regulation KPNA1(DISRUPTS); PPP2CA(INDUCES); KPNB1(DISRUPTS) 21419339; 23374587; 23926298 6 3 0 Phosphorylation of SET leads to PP2A inhibition which leads to Tau hyperphosphorylation; beta-2AR phosphorylation and signaling; oncogenic kinase Jak2V617F signaling and tumor suppressor (PP2A) activity; PP2A activity inhibited +H3F3C H3 DNA-binding P84229 427887 chicken K9-m2 459006 RTKQTARkSTGGKAP Histone transcription, inhibited 19950192 119 21 0 +MEF2C MEF2C DNA-binding; Transcription factor Q06413 4208 5q14.3 human K234-ac 12674408 VSPGNLNkNMQAKSP molecular association, regulation cell differentiation, induced; transcription, induced MRF(INDUCES) DNA(INDUCES) 15831463 1 0 0 +MAP2K5 MEK5 EC 2.7.12.2; KINASE; Kinase, protein; Protein kinase, STE; Protein kinase, dual-specificity (non-receptor) Q13163 5607 15q23 human T315-p 448622 LVNSIAKtYVGTNAY Pkinase molecular association, regulation; intracellular localization; enzymatic activity, induced ERK5(DISRUPTS) 14583600; 7759517 3 1 0 +MICAL2 MICAL2 Adaptor/scaffold; EC 1.14.13.- O94851 9645 11p15.3 human Y445-p 1875329206 LAERESLyRLLPQTT carcinogenesis, induced; cell motility, induced; cell growth, induced; cytoskeletal reorganization 34750518 1 1 0 +Pcna PCNA Cell cycle regulation; DNA replication P17918 18538 2 F2|2 64.15 cM mouse Y114-p 27281500 NQEKVSDyEMKLMDL PCNA_N cell cycle regulation; cell differentiation, induced 23201573; 28915506 2 0 2 distribution of body mass; Y114F +/+ mutant does not re-enter cell cycle for clonal expansion. Y114F+/+ mice are is resistant to diet-induced obesity compared to WT. +LIMK2 LIMK2 EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, Ser/Thr (non-receptor); Protein kinase, TKL P53671 3985 22q12.2 human S283-p 456167 EGTLRRRsLRRSNSI protein stabilization; intracellular localization cell adhesion, induced 15923181; 16820362; 22492986 4 1 10 +DVL2 DVL2 Adaptor/scaffold; Motility/polarity/chemotaxis O14641 1856 17p13.1 human K615-ub 15490613 EERAPESkSGSGSES Dsh_C molecular association, regulation; intracellular localization cell motility, induced; signaling pathway regulation Cofilin-1(INDUCES); VANGL1(INDUCES) 31340145 1 4 1 DVL2 variant with all encoded lysine residues mutated to arginine is sufficient to restore WNT activation +GNAT1 G-alpha t1 G protein; G protein, heterotrimeric; G protein, heterotrimeric alpha G((i/o/t/z)) P04695 281794 cow Y142-p 470102 CFDRASEyQLNDSAG G-alpha molecular association, regulation Src(INDUCES) 11032890 1 1 0 Tyrosine phosphorylation of GNAT1 increases association with Src. +H3-3A H3 DNA-binding Q71LE2 396970 pig K9-m3 1458613 RTKQTARkSTGGKAP Histone transcription, inhibited 32893712 137 24 1 mesenchymal stem/stroma cells of obese pigs had suppressed transcription compared to lean pigs +PLK1 PLK1 EC 2.7.11.21; KINASE; Kinase, protein; Protein kinase, Other; Protein kinase, Ser/Thr (non-receptor) P53350 5347 16p12.2 human K209-m1 1879811202 EYDGERKkTLCGTPN cell cycle regulation; DNA repair, induced 30854428 1 1 0 required for DNA damage repair; K209 peaks at S phase and may be required for DNA replication; K209 severely delays metaphase-to-anaphase transition +Sharpin SHARPIN Apoptosis Q91WA6 106025 15 D3|15 35.75 cM mouse K169-ub 54221303 QSSGNFKkEELATRL signaling pathway regulation 26829767 1 1 0 regulation of TCR signaling-maintenance of immuno; ogical signaling K63-linked polyubiquitination +Nefl NFL Cytoskeletal P08551 18039 14|14 D1 mouse S44-p 27430100 RSAYSSYsAPVSSSL Filament_head molecular association, regulation; intracellular localization 14-3-3 gamma(INDUCES) 23230147 1 0 0 regulates NF-L dynamic exchange rate and neurofilament disassembly +CEACAM3 CEACAM3 Cell adhesion; Immunoglobulin superfamily; Membrane protein, integral P40198 1084 19q13.2 human Y241-p 1879727800 LKHDTNIyCRMDHKA endocytosis, induced 35850306 1 0 0 induces phagocytosis +SLC9A3 NHE3 Membrane protein, integral; Membrane protein, multi-pass; Transporter; Transporter, SLC family P48764 6550 5p15.33 human S663-p 457469 TMRKRLEsFKSTKLG intracellular localization 25855080 4 1 2 trafficking of NHE3 to the apical membrane +PRKDC DNAPK DNA repair, damage; EC 2.7.11.1; KINASE; Kinase, protein; Nucleolus; Protein kinase, Ser/Thr (non-receptor); Protein kinase, atypical P78527 5591 8q11.21 human S2056-p 455794 VQSYSYSsQDPRPAT DNAPKcs_CC3 activity, induced; molecular association, regulation; intracellular localization; phosphorylation; enzymatic activity, induced cell cycle regulation; carcinogenesis, induced; carcinogenesis, inhibited; cell growth, inhibited; signaling pathway regulation; DNA repair, induced; chromatin organization, altered; apoptosis, inhibited; DNA repair, inhibited; cell growth, altered EphA2(INDUCES) DNA(INDUCES) 17189255; 19071136; 21653549; 24687855; 24844881; 25818648; 26603896; 31679687; 31980741; 32085396; 33671073; 33879618; 35740300; 35798878; 35972384; 36183837; 36755959 53 4 3 +PA2G4 Ebp1 Nuclear receptor co-regulator; Nucleolus; Transcription, coactivator/corepressor Q9UQ80 5036 12q13.2 human S34-p 35542202 IANRVLRsLVEASSS Peptidase_M24 carcinogenesis, induced; cell differentiation, induced; apoptosis, inhibited 25154617 1 0 0 +Mitf MITF DNA-binding; Oncoprotein; Transcription factor Q08874 17342 6 D3|6 45.05 cM mouse K289-sm 3590701 PANLPNIkRELTACI transcription, inhibited 16029420 3 1 0 +Met Met EC 2.7.10.1; KINASE; Kinase, protein; Membrane protein, integral; Oncoprotein; Protein kinase, TK; Protein kinase, tyrosine (receptor) P16056 17295 6 A2|6 7.83 cM mouse Y1228-p 448866 FGLARDMyDKEYYSV PK_Tyr_Ser-Thr enzymatic activity, induced 19595710 7 11 108 +LCP2 SLP76 Adaptor/scaffold Q13094 3937 5q35.1 human S376-p 476784 SSFPQSAsLPPYFSQ protein degradation; molecular association, regulation; ubiquitination transcription, altered 14-3-3 zeta(INDUCES); 14-3-3 epsilon(INDUCES); 14-3-3 gamma(INDUCES) 17353368; 22902619 5 1 0 +XRCC5 Ku80 DNA-binding; EC 3.6.1.-; EC 3.6.4.-; Helicase; Nuclear receptor co-regulator; Nucleolus; RNA-binding P13010 7520 2q35 human K534-ub 15391478 QIPLSKIkTLFPLIE Ku_C molecular association, regulation DNA repair, induced DNA(DISRUPTS) 27895153 1 7 3 +HBP1 HBP1 DNA-binding; Transcription factor O60381 26959 7q22.3 human K305-ac 25171017 LDHPFYVkNKGWSSF AXH transcription, inhibited 23249948 2 0 0 acetylation of the five sites induces transcriptional repression of the DNMT1 gene, regulates cellular senescence +GLI1 GLI1 C2H2-type zinc finger protein; Oncoprotein; Transcription factor P08151 2735 12q13.3 human K180-sm 1873076602 PFPTCQLkSELDMLV protein stabilization; ubiquitination; intracellular localization cell growth, induced; transcription, induced; signaling pathway regulation 28630282 1 0 0 inhibits ubiquitination, enhances Shh signaling +Casp4 CASP4 Apoptosis; EC 3.4.22.64; Protease P70343 12363 9 A1|9 2.46 cM mouse K63-ub 1877676803 VFVDAMKkKHSKVGE CARD protein degradation 30816303 1 0 0 +CIC capicua DNA-binding; Transcription factor Q96RK0 23152 19q13.2 human S173-p 3209781 PGKRRTQsLSALPKE protein degradation; molecular association, regulation; ubiquitination; intracellular localization transcription, induced; transcription, altered 14-3-3 theta(INDUCES); 14-3-3 epsilon(INDUCES); PJA1(INDUCES) DNA(INDUCES) 21087211; 30737375; 33103082 3 40 9 +TP53 p53 Activator; DNA-binding; Motility/polarity/chemotaxis; Nuclear receptor co-regulator; Transcription factor; Tumor suppressor P04637 7157 17p13.1 human T55-p 450685 DDIEQWFtEDPGPDE TAD2 activity, induced; protein degradation; molecular association, regulation; ubiquitination; intracellular localization; protein conformation; activity, inhibited cell cycle regulation; carcinogenesis, induced; apoptosis, altered; apoptosis, induced; transcription, induced; signaling pathway regulation; transcription, altered; cell growth, induced; apoptosis, inhibited; transcription, inhibited S100B(INDUCES); TFB1M(INDUCES); S100A1(INDUCES); S100A4(INDUCES); GTF2H1(INDUCES); Exportin-1(INDUCES); S100A6(INDUCES); SERCA2(DISRUPTS); MDM2(INDUCES); S100A2(INDUCES) DNA(DISRUPTS) 11409876; 15053879; 15116093; 16793543; 17245430; 18160537; 18952844; 19819244; 20124405; 22525275; 23723076; 24289924; 26029824; 28673515; 29988038; 33256128; 33443163; 33745968; 34798143 24 0 0 arsenic induced overexpression of PUMA, P53 phosphorylation and acetylation, activation and accumulation of p53, PUMA disruption of Bcl-X complexes with pro-survival proteins resulting in apoptosis +Ssh2 SSH2 Actin-binding; EC 3.1.3.16; EC 3.1.3.48; PHOSPHATASE; Protein phosphatase, dual-specificity Q5SW75 237860 11|11 B5 mouse S21-p 17544228 TTSSPCAsEADSGEE enzymatic activity, inhibited cytoskeletal reorganization; cell motility, inhibited 22172670 1 1 0 +Jak2 JAK2 EC 2.7.10.2; KINASE; Kinase, protein; Oncoprotein; Protein kinase, TK; Protein kinase, tyrosine (non-receptor) Q62120 16452 19 C1|19 23.73 cM mouse Y221-p 451493 VRAKIQDyHILTRKR FERM_F2 enzymatic activity, induced 15143187; 25002528 14 5 1 +WIPF1 WIPF1 Actin-binding; Motility/polarity/chemotaxis O43516 7456 2q31.1 human S154-p 23073655 PGRFPVPsPGHRSGP cell growth, induced 28166194 1 2 6 +RELA NFkB-p65 DNA-binding; Nuclear receptor co-regulator; Transcription factor Q04206 5970 11q13.1 human T352-gl 5148301 APQPYPFtSSLSTIN molecular association, regulation; intracellular localization transcription, induced IkB-alpha(DISRUPTS) DNA(INDUCES) 18988733; 25915426 3 2 0 +MAD2L1BP MAD2L1BP Cell cycle regulation Q15013 9587 6p21.1 human S102-p 1245332 KHFYRKPsPQAEEML p31comet molecular association, regulation; enzymatic activity, inhibited cell cycle regulation Mad2(DISRUPTS) 24596092; 31118282 2 14 3 promotes SAC activity in mitosis +MECOM EVI1 C2H2-type zinc finger protein; Methyltransferase, protein lysine, predicted; Oncoprotein; Transcription regulation; Transcription, coactivator/corepressor Q03112 2122 3q26.2 human S726-p 4703001 PLKMEPQsPGEVKKL molecular association, regulation cell motility, induced; cell growth, induced; transcription, induced DNA(INDUCES) 23858473 1 11 0 +MAF MAF Cell development/differentiation; DNA-binding; Oncoprotein; Transcription factor; Tumor suppressor O75444 4094 16q23.2 human K350-ub 37043500 AYKEKYEkLVSSGFR bZIP_Maf protein stabilization transcription, induced 25448412 1 0 0 +Prkaca PKACA EC 2.7.11.11; KINASE; Kinase, protein; Protein kinase, AGC; Protein kinase, Ser/Thr (non-receptor) P27791 25636 19q11 rat T198-p 448459 RVKGRTWtLCGTPEY Pkinase signaling pathway regulation 23490331 34 48 277 diabetes-type1 and type2-related signaling in brain +Arhgef7 ARHGEF7 GEF; GEF, Rac/Rho; Motility/polarity/chemotaxis O55043 114559 16q12.5 rat T526-p 455216 EFAVRKStAALEEDA RhoGEF67_u2 molecular association, regulation; intracellular localization cytoskeletal reorganization 14-3-3 beta(INDUCES) 15513924; 18160719 7 6 1 binding to 14-3-3 beta requires protein dimerization; translocated to Focal complexes +DGCR8 DGCR8 Nucleolus; RNA processing; RNA-binding Q8WYQ5 54487 22q11.21 human S275-p 3208080 GGDSDHPsDGETSVQ protein stabilization 24239349 1 36 4 +TJP2 ZO2 Adaptor/scaffold; Motility/polarity/chemotaxis Q95168 403854 dog S257-gl 28700304 PDARHAGsRSRSREH protein degradation; intracellular localization; phosphorylation 23804652 1 0 0 GlcNAcylated S257 is no longer phosphorylated and directed to TJs, instead becomes degraded +Ilf3 NFAT90 DNA-binding; Nucleolus; RNA-binding; Transcription factor Q9Z1X4 16201 9 A3|9 7.78 cM mouse T315-p 17734000 RQQREDItQSAQHAL DZF molecular association, regulation; intracellular localization translation, altered ILF2(DISRUPTS) 21123651 3 0 0 +ATG4B ATG4B Autophagy; EC 3.4.22.-; Protease; Ubiquitin conjugating system Q9Y4P1 23192 2q37.3 human S392-p 470322 DEDFEILsL______ molecular association, regulation; enzymatic activity, induced autophagy, induced LC3A(INDUCES) 26378241 2 8 0 +Traf3ip2 TRAF3IP2 Apoptosis; UBIQUITIN LIGASE; Ubiquitin conjugating system; Ubiquitin ligase Q8N7N6 103213 10|10 B1 mouse S147-p 25687507 ESDKSDPsLPNALAD molecular association, regulation transcription, inhibited TRAF6(DISRUPTS) 22851696 1 0 0 +USP10 USP10 DEUBIQUITINASE; EC 3.4.19.12; Protease; RNA-binding; Ubiquitin conjugating system; Ubiquitin-specific protease Q14694 9100 16q24.1 human T674-p 10801134 VEISRRVtLEKLPPV UCH intracellular localization 34983926 1 0 1 inhibits AID degradation +Slc12a5 KCC2 iso2 Membrane protein, integral; Membrane protein, multi-pass; Transporter; Transporter, SLC family Q91V14-2 57138 2|2 H3 mouse T1006-p 10045602 TDPEVHLtWTKDKSV neural plasticity 31396048 9 5 1 regulates hyperpolarizing synaptic inhibition and adulthood cognitive function +TP53 p53 Activator; DNA-binding; Motility/polarity/chemotaxis; Nuclear receptor co-regulator; Transcription factor; Tumor suppressor P04637 7157 17p13.1 human K382-ub 464658 QSTSRHKkLMFKTEG protein degradation; molecular association, regulation; intracellular localization transcription, inhibited ING1(DISRUPTS) 11046142; 17371868; 19927155; 21731648; 31002112 10 0 0 K370/372/373/381/382/386/R mutant shows 613-fold activation of p53; binds unmodified or six multimonoubiquitinated forms of wild-type p53; translocation of p53 from the nucleus to the cytoplasm, promotes EMT in EOC cells +ESR1 ER-alpha DNA-binding; Nuclear receptor; Transcription factor P03372 2099 6q25.1-q25.2 human S341-p 33663900 TRPFSEAsMMGLLTN Hormone_recep protein degradation; molecular association, regulation; ubiquitination cell cycle regulation; transcription, induced SKP2(INDUCES) 23770852 1 0 0 ERalpha-SKP2 binding caused degradation of ERalpha +Irf3 IRF3 DNA-binding; Transcription factor P70671 54131 7|7 B3 mouse S388-p 449028 KTVDLHIsNSQPISL intracellular localization; enzymatic activity, induced transcription, induced 24270516; 33941660; 34161773; 34433039; 34969857; 35320000 75 6 0 +H3C1 H3 DNA-binding P68431 8350 6p22.2 human K9-m3 1458613 RTKQTARkSTGGKAP Histone sumoylation; molecular association, regulation; intracellular localization cell cycle regulation; cell differentiation, inhibited; apoptosis, induced; cell motility, induced; cell adhesion, induced; transcription, induced; transcription, altered; cell differentiation, altered; DNA repair, induced; cell differentiation, induced; cell growth, induced; chromatin organization, altered; cytoskeletal reorganization; transcription, inhibited UHRF1(INDUCES); CDYL2(INDUCES); ZNF828(INDUCES); HSFY1(INDUCES); MAD2L2(INDUCES); HP1 alpha(INDUCES); WDR42A(INDUCES); DNMT1(INDUCES); CBX3(INDUCES); CBX1(INDUCES); Tip60(INDUCES); ORC2(INDUCES); AGO3(INDUCES); CHD-4(INDUCES); POGZ(INDUCES); ZNF470(INDUCES); RCOR1(DISRUPTS); CDYL(INDUCES) DNA(INDUCES) 16732292; 16732293; 16858404; 17066076; 17237781; 17968314; 18004385; 18234970; 18701507; 18835819; 19021773; 19022177; 19546172; 19624289; 19706462; 19783983; 19811652; 19889207; 20070858; 20159609; 20221260; 20404330; 20613843; 20716953; 20850016; 21059703; 21156283; 21489993; 24292684; 28674400; 29370823; 31015297; 32232334; 32675241; 32908309; 34720086; 35322029; 36461911 137 24 1 +GAK GAK Cell cycle regulation; EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, Other; Protein kinase, Ser/Thr (non-receptor) O14976 2580 4p16.3 human Y412-p 63063501 KGDLDISyITSRIAV cell cycle regulation 28135906 1 0 0 +PTTG1 Securin Cell cycle regulation; Oncoprotein O95997 9232 5q33.3 human S183-p 20764101 SNLLQSPsSILSTLD Securin protein degradation cell cycle regulation 21757741 2 0 0 +Camk2b CAMK2B EC 2.7.11.17; KINASE; Kinase, protein; Protein kinase, CAMK; Protein kinase, Ser/Thr (non-receptor) P08413 24245 14q21 rat S367-p 456904 KNSSAITsPKGSLPP molecular association, regulation 26291163 1 14 1 inhibits interaction with F-actin, regulates synaptic plasticity +PTEN PTEN Carbohydrate Metabolism - inositol phosphate; EC 3.1.3.16; EC 3.1.3.48; EC 3.1.3.67; Motility/polarity/chemotaxis; Nuclear receptor co-regulator; PHOSPHATASE; Phosphatase, lipid; Tumor suppressor P60484 5728 10q23.31 human K163-ac 3833098 GEVRTRDkKGVTIPS intracellular localization; protein conformation; phosphorylation carcinogenesis, inhibited; cell growth, inhibited; cell motility, inhibited 26279303 1 0 1 inhibits AKT phosphorylation +WAC WAC Adaptor/scaffold Q9BTA9 51322 10p12.1|10p12.1-p11.2 human T244-p 36128588 AETHSSStPVQHPIK molecular association, regulation; phosphorylation cell cycle regulation PLK1(INDUCES) 30021153 1 1 0 +DDR1 DDR1 EC 2.7.10.1; KINASE; Kinase, protein; Membrane protein, integral; Protein kinase, TK; Protein kinase, tyrosine (receptor) Q08345 780 6p21.33 human Y703-p 462887 PLCMITDyMENGDLN PK_Tyr_Ser-Thr molecular association, regulation SHP-2(INDUCES) 16611743 1 0 0 required for the DDR1-mediated suppression of tyrosine phosphorylation of Stat1 and Stat3, cell migration, branching tubulogenesis +Mknk1 Mnk1 EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, CAMK; Protein kinase, Ser/Thr (non-receptor); Translation O08605 17346 4|4 D1 mouse T209-p 447621 NSCTPITtPELTTPC Pkinase molecular association, regulation; enzymatic activity, induced eIF4G(INDUCES) 10022874 14 1 1 +SPDEF SPDEF DNA-binding; Motility/polarity/chemotaxis; Nuclear receptor co-regulator; Transcription factor O95238 25803 6p21.31 human S242-p 54165903 WTDSEVDsSCSGQPI protein degradation cell motility, induced 26885618 1 0 0 enhances migration and invasion of prostate cancer cells +HMGN1 HMGN1 DNA-binding; Nuclear receptor co-regulator P05114 3150 21q22.2 human K3-ac 458843 _____MPkRKVSSAE HMG14_17 molecular association, regulation DNA(DISRUPTS) 10753971 2 0 0 +MRE11 MRE11A Cell cycle regulation; DNA repair, damage; DNA-binding; Deoxyribonuclease P49959 4361 11q21 human R587-me 2344811 RGQNSASrGGSQRGR intracellular localization 15970667 2 0 0 localizes in nucleus and associates with nuclear bodies and sites of DNA damage +WWP2 WWP2 EC 6.3.2.-; EC 6.3.2.19; Ligase; UBIQUITIN LIGASE; Ubiquitin conjugating system; Ubiquitin ligase O00308 11060 16q22.1 human Y369-p 464298 TAEYVRNyEQWQSQR enzymatic activity, induced autophagy, induced 35331737 1 2 12 +HDAC9 HDAC9 DEACETYLASE; Deacetylase; EC 3.5.1.98; Transcription, coactivator/corepressor Q9UKV0 9734 7p21.1 human S220-p 448485 FPLRKTAsEPNLKVR molecular association, regulation; intracellular localization 14-3-3 beta(INDUCES) 20188095 3 19 25 +BCL2L11 BIM Apoptosis O43521 10018 2q13 human T116-p 449071 SCDKSTQtPSPPCQA molecular association, regulation autophagy, induced; apoptosis, inhibited LC8(DISRUPTS); beclin 1(DISRUPTS); MCL1(INDUCES); Bcl-2(INDUCES) 22742832; 34193942 10 1 0 +ERO1A ERO1L EC 1.8.4.-; Oxidoreductase; Secreted; Secreted, signal peptide Q96HE7 30001 14q22.1 human S145-p 36122817 GAVDESLsEETQKAV ERO1 intracellular localization; protein conformation; enzymatic activity, induced 29858230 1 4 0 regulates ER redox, promotes oxidative folding of proteins +HIPK2 HIPK2 EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, CMGC; Protein kinase, Ser/Thr (non-receptor) Q9H2X6 28996 7q34 human K671-ub 3059904 GLQASPSkHAGYSVR protein degradation 18536714 1 0 0 +Gria2 GluR2 Channel, calcium; Channel, ligand-gated; Membrane protein, integral; Membrane protein, multi-pass P19491 29627 2q33 rat S880-p 448351 YNVYGIEsVKI____ molecular association, regulation; ubiquitination; intracellular localization; receptor internalization, altered; receptor recycling, altered; activity, inhibited GRIP1(DISRUPTS) 10856222; 11007883; 14534256; 17145504; 18077702; 19279258; 32052226 30 1 0 Ser-880 is su?cient but is not necessary for the augmentation of bicuculline-induced GluA2 ubiquitination +VWF VWF Cell adhesion; Extracellular matrix; Motility/polarity/chemotaxis; Secreted; Secreted, signal peptide P04275 7450 12p13.31 human S1613-p 1867984205 MVTGNPAsDEIKRLP VWA cell adhesion, induced 30864273 1 1 0 increases platelet adhesion under shear conditions +Irak2 IRAK2 KINASE; Kinase, protein; Protein kinase, Ser/Thr (non-receptor); Protein kinase, TKL Q8CFA1 108960 6 E3|6 52.82 cM mouse T140-p 18262495 KPRSLLDtGPIMAGA molecular association, regulation; intracellular localization signaling pathway regulation PHB(INDUCES); OPA1(INDUCES); TIMM50(INDUCES) 32778760 1 2 0 IL-1R?MyD88?IRAK2?PHB/OPA1 signaling pathway +MMP14 MMP14 EC 3.4.24.80; Membrane protein, integral; Motility/polarity/chemotaxis; Protease P50281 4323 14q11.2 human Y573-p 478362 GTPRRLLyCQRSLLD DUF3377 molecular association, regulation; intracellular localization cell cycle regulation; carcinogenesis, induced; carcinogenesis, altered; cell motility, altered; transcription, induced; cell growth, altered P130Cas(INDUCES); FAK(INDUCES) 17389600; 18621744; 19509114; 20651331; 22291036; 23548906 7 3 39 peptide antagonist (ACM-14) carrying mutation (Y573F) of this site inhibits tumor cell proliferation ; MMP14 overexpression induces CSF-2, CSF-3 gene expression and requires Y573-p.; ECM degradation at focal adhesions +Ptk2 FAK EC 2.7.10.2; KINASE; Kinase, protein; Protein kinase, TK; Protein kinase, tyrosine (non-receptor) P34152 14083 15 D3|15 33.94 cM mouse S843-p 447963 DVRLSRGsIDREDGS phosphorylation 15845548 7 14 7 decreases phosphorylation at FAK Tyr397 +Polb POLB DNA repair, damage; DNA replication; EC 2.7.7.7; Lyase; Transferase P06766 29240 16q12.5 rat S55-p 41521701 KYPHKIKsGAEAKKL HHH_8 enzymatic activity, inhibited 2040602 3 0 0 +NR5A1 STF-1 Nuclear receptor; Transcription, coactivator/corepressor Q13285 2516 9q33.3 human S203-p 447603 EYPEPYAsPPQPGLP activity, induced; molecular association, regulation transcription, induced PITX1(INDUCES) 14596681; 17901130; 19995909; 35592512 11 0 0 +H3-4 HIST3H3 DNA-binding Q16695 8290 1q42.13 human K79-m1 8113918 REIAQDFkTDLRFQS Histone molecular association, regulation L3MBTL iso4(INDUCES) 23583077 0 4 37 +FPR1 FPR1 GPCR, family 1; Membrane protein, integral; Membrane protein, multi-pass; Motility/polarity/chemotaxis; Receptor, GPCR P21462 2357 19q13.41 human T336-p 450844 TQTSDTAtNSTLPSA receptor desensitization, altered; receptor internalization, altered 10514456 2 1 0 +NACA NACA Motility/polarity/chemotaxis; Transcription, coactivator/corepressor E9PAV3 4666 12q13.3 human T2022-p 451197 NIQENTQtPTVQEES protein stabilization; intracellular localization transcription, altered 15005626 1 13 0 +PIK3CB PIK3CB Carbohydrate Metabolism - inositol phosphate; EC 2.7.1.153; KINASE; Kinase, lipid; Motility/polarity/chemotaxis P42338 5291 3q22.3 human K952-sm 1881459301 FKSKFGIkRERVPFI protein stabilization signaling pathway regulation 33834259 1 0 0 PI3K signaling pathway, PI3K regulatory subunit p85-beta inhibits K952 SUMOylation +Camk2b CAMK2B EC 2.7.11.17; KINASE; Kinase, protein; Protein kinase, CAMK; Protein kinase, Ser/Thr (non-receptor) P08413 24245 14q21 rat S358-p 15719516 GVKPQTNsTKNSSAI molecular association, regulation 26291163 1 2 0 inhibits interaction with F-actin, regulates synaptic plasticity +Stx7 STX7 Membrane protein, integral; Vesicle O70439 53331 10|10 A4 mouse S129-p 468882 VRASSRVsGGFPEDS molecular association, regulation STX8(INDUCES); VTI1B(INDUCES); VAMP8(INDUCES) 18710945 1 45 189 +HDAC9 HDAC9 DEACETYLASE; Deacetylase; EC 3.5.1.98; Transcription, coactivator/corepressor Q9UKV0 9734 7p21.1 human S451-p 448486 RPLNRTQsAPLPQST molecular association, regulation; intracellular localization 14-3-3 beta(INDUCES) 20188095 3 5 6 +SLC12A1 NKCC2 Membrane protein, integral; Membrane protein, multi-pass; Transporter; Transporter, SLC family Q13621 6557 15q21.1 human T105-p 458228 LQTFGHNtMDAVPKI AA_permease_N activity, induced signaling pathway regulation 21321328 14 2 0 WNK-SPAK-OSR1 pathway +PNPLA8 PNPLA8 EC 3.1.1.5; Membrane protein, integral; Motility/polarity/chemotaxis; Phospholipase Q9NP80 50640 7q31.1 human S511-p 18638838 ELYRKLGsDVFSQNV Patatin activity, induced; enzymatic activity, induced transcription, induced; signaling pathway regulation 23258543; 25492867 2 1 0 Increase PGE2 release and leads to conformational change in the enzyme; ATF6 activation +USP16 USP16 DEUBIQUITINASE; EC 3.4.19.12; Protease; Ubiquitin conjugating system; Ubiquitin-specific protease Q9Y5T5 10600 21q21.3 human S415-p 3217536 VEDEDQDsEEEKDND UCH protein degradation 28380042 1 40 0 +Map2 MAP2 iso3 Cytoskeletal; Motility/polarity/chemotaxis P15146-3 25595 9q32 rat K311-ac 36300530 NQPLPDLkNVKSKIG Tubulin-binding cytoskeletal reorganization 28002468 1 2 0 +Tsc2 TSC2 iso2 Cell cycle regulation; GAP; GAP, misc.; Nuclear receptor co-regulator; Tumor suppressor P49816-2 24855 10q12 rat S1211-p 448807 TALYKSLsVPAAGTA molecular association, regulation 14-3-3 beta(INDUCES) 12364343 6 23 14 +SDCBP syntenin Adaptor/scaffold; Cell adhesion; Cytokine; Membrane protein, integral; Motility/polarity/chemotaxis; Vesicle O00560 6386 8q12.1 human T200-p 1869341900 RPFERTItMHKDSTG Peptidase_M50; PDZ protein stabilization; molecular association, regulation carcinogenesis, induced; signaling pathway regulation Src(INDUCES); EGFR(INDUCES); FAK(INDUCES) 32572158 1 0 0 AURKA-SDCBP-EGFR-PI3K-AKT pathway; Inhibits ubiquitination +Cdk16 CDK16 Cell cycle regulation; EC 2.7.11.22; KINASE; Kinase, protein; Motility/polarity/chemotaxis; Protein kinase, CMGC; Protein kinase, Ser/Thr (non-receptor) Q04735 18555 X A1.3|X 16.18 cM mouse S153-p 453451 SRRLRRVsLSEIGFG molecular association, regulation; intracellular localization CBCP1(DISRUPTS); CCNYL1(DISRUPTS) 22184064; 26305884 3 58 166 +Bex1 BEX1 Cell cycle regulation; Cell development/differentiation Q3MKQ2 501625 Xq35 rat S105-p 14788300 KLRERQLsHSLRAVS BEX protein stabilization 16498402 1 1 0 +Srebf1 SREBP-1 iso1 DNA-binding; Membrane protein, integral; Membrane protein, multi-pass; Transcription factor P56720-1 78968 10q22 rat S419-p 56654316 LGSRGSSsGGSDSEP protein stabilization; molecular association, regulation; intracellular localization transcription, induced SCAP(INDUCES) 31541353 1 2 0 activates genes involved in de novo lipogenesis +LAIR1 LAIR-1 Membrane protein, integral; Receptor, misc. Q6GTX8 3903 19q13.42 human Y251-p 449020 GSSQEVTyAQLDHWA molecular association, regulation signaling pathway regulation CSK(INDUCES); SHP-1(INDUCES) 10764762; 31932281 2 1 39 TCR signaling/suppression of TCR signaling +CPSF3 CPSF3 EC 3.1.27.-; RNA processing; RNA splicing; RNA-binding; Ribonuclease Q9UKF6 51692 2p25.1 human K545-sm 2586337 EELEIQEkPALKVFK CPSF73-100_C RNA splicing, altered; cell growth, induced 17923699 1 0 0 regulation of mRNA 3'-end processing- cleavage and polyadenylation +SASS6 SAS6 Cell cycle regulation Q6UVJ0 163786 1p21.2 human T495-p 15414716 DVLGPSTtPPAHSSS molecular association, regulation; intracellular localization cell cycle regulation NEDD1(DISRUPTS); STIL(DISRUPTS) 36356903 1 2 1 +PARP1 PARP1 DNA repair, damage; EC 2.4.2.30; Nuclear envelope; Nuclear receptor co-regulator; Nucleolus; Transferase P09874 142 1q42.12 human S179-p 481744 FRPEYSAsQLKGFSL zf-PARP enzymatic activity, inhibited 33811702 1 8 6 regulates necrotic cell death/ necrosis +KLF2 KLF2 C2H2-type zinc finger protein; DNA-binding Q9Y5W3 10365 19p13.11 human K148-sm 31089515 TRGPRGLkREGAPGP transcription, inhibited 23515309 1 0 0 +RIGI RIGI EC 3.6.4.13; Hydrolase O95786 23586 9p21.1 human K154-ub 7761219 GMMAGAEkLVECLLR CARD_2 transcription, induced 19484123 1 0 0 induces DDX58-mediated innate antiviral activity +Map2 MAP2 iso3 Cytoskeletal; Motility/polarity/chemotaxis P15146-3 25595 9q32 rat K337-ac 62495511 GQVQIVTkKIDLSHV Tubulin-binding cytoskeletal reorganization 28002468 1 1 0 +CKAP4 CKAP4 Endoplasmic reticulum; Membrane protein, integral Q07065 10970 12q23.3 human S17-p 455354 KGGHGAAsPSEKGAH molecular association, regulation; intracellular localization; palmitoylation neural plasticity; cell growth, inhibited; cytoskeletal reorganization; transcription, altered; signaling pathway regulation DNA(INDUCES) 15703217; 22265418; 22536245 3 12 0 +MVB12B FAM125B Vesicle Q9H7P6 89853 9q33.3 human Y241-p 6209987 RNSTRTDyEYQHSNL DUF2464 protein degradation; ubiquitination 20654576 1 0 3 +Rptor Raptor Adaptor/scaffold Q8K4Q0 74370 11|11 E2 mouse S1189-p 23137513 VAGLGDGsIRVYDRR WD40 protein degradation; molecular association, regulation; ubiquitination cell growth, inhibited; signaling pathway regulation USP9X(DISRUPTS) 37395713 1 0 1 inhibits mTORC1 pathway +Themis THEMIS Cell development/differentiation Q8BGW0 210757 10|10 A4 mouse Y542-p 27806313 EEITEEQyYMMRRYE cell differentiation, induced 23460737 1 1 0 thymocyte development +Ephb2 EphB2 EC 2.7.10.1; KINASE; Kinase, protein; Membrane protein, integral; Protein kinase, TK; Protein kinase, tyrosine (receptor); Tumor suppressor P54763 13844 4 D3|4 69.0 cM mouse Y930-p 448334 EAIKMGQyKESFANA SAM_1 molecular association, regulation GRB10(INDUCES) 8798570 3 2 0 necessary for binding to Grb10 SH2, but not Grb2. +Mapk7 ERK5 EC 2.7.11.24; KINASE; Kinase, protein; Protein kinase, CMGC; Protein kinase, Ser/Thr (non-receptor) Q9WVS8 23939 11|11 B2 mouse Y221-p 448206 HQYFMTEyVATRWYR Pkinase carcinogenesis, induced; cell adhesion, induced; signaling pathway regulation 33687949 20 28 955 ERK5/ P70S6K/RAC1 pathway +L1CAM NCAM-L1 Cell adhesion; Membrane protein, integral P32004 3897 Xq28 human S1181-p 465573 GEYRSLEsDNEEKAF Bravo_FIGEY molecular association, regulation; intracellular localization; phosphorylation cell motility, altered; cytoskeletal reorganization; cell adhesion, inhibited ANK3(INDUCES) 17151951; 17253643; 19720049; 29109170 6 23 5 L1 sensitivity to ethanol; axonal growth +Etv4 ETV4 DNA-binding P28322 18612 11 D|11 65.48 cM mouse K442-ac 26373308 DNQRPALkAEFDRPV sumoylation transcription, induced 21543453 1 1 0 acetylated sites inhibits sumoylation reciprocally +CDCP1 CDCP1 Cell surface; Membrane protein, integral Q9H5V8 64866 3p21.31 human Y734-p 451434 KDNDSHVyAVIEDTM molecular association, regulation; intracellular localization; phosphorylation carcinogenesis, induced; cell growth, induced; cell motility, induced; cell adhesion, induced; cell motility, altered; cytoskeletal reorganization Src(INDUCES); PKCD(INDUCES); SHP-2(INDUCES) 14739293; 15851033; 20501830; 21725358; 21994943; 23300860; 25728678; 25876044 10 3 12 Tyr734 is a key precursor phosphorylation event allowing Tyr707 and Tyr806 phosphorylation +Hspb6 HSP20 Chaperone; Heat shock protein Q5EBG6 243912 7|7 B1 mouse S16-p 450706 PSWLRRAsAPLPGFS Crystallin activity, induced; molecular association, regulation; intracellular localization; protein processing; activity, inhibited apoptosis, altered; cell growth, induced; cell differentiation, induced; apoptosis, inhibited; transcription, induced; cytoskeletal reorganization; signaling pathway regulation PPA1(INDUCES); HSP20(DISRUPTS) 19850943; 20854253; 23713735; 24244723; 30845231; 31061921 21 31 2 regulates IL-6/STAT3 signaling pathway; differentiation ?broblasts to myo?broblasts, fibrotic remodeling; increase IL-6 expression; inhibit endoplasmic reticulum OGD/R -related structural changes and Golgi apparatus OGD/R -related fragmentation; Reduced mitochondrial fragmentation. Bcl-2 expression increased, Bax expression decreased.; nuclear translocation of STAT3; increases the level of Golgi stress-related proteins but decreases the level ER stress-related proteins +Gata1 GATA1 DNA-binding; Transcription factor P17679 14460 X A1.1|X 3.59 cM mouse S26-p 451232 VDSALVSsPSDSTGF activity, induced; protein degradation; acetylation; molecular association, regulation; ubiquitination; phosphorylation cell differentiation, inhibited; apoptosis, inhibited; transcription, induced LMO2(INDUCES) DNA(INDUCES) 15167914; 15967790; 16858405; 23717580 6 0 0 +Pik3c3 PIK3C3 Autophagy; Carbohydrate Metabolism - inositol phosphate; EC 2.7.1.137; Kinase, lipid; Motility/polarity/chemotaxis Q6PF93 225326 18|18 B1 mouse T159-p 14659500 DGSEPTRtPGRTSST PI3K_C2 neural plasticity; endocytosis, inhibited 35318705 2 0 0 +ATF5 ATF-5 DNA-binding Q9Y2D1 22809 19q13.33 human K29-ac 20745204 GWLVDYGkLPPAPAP molecular association, regulation carcinogenesis, induced; cell growth, induced; apoptosis, inhibited; transcription, induced DNA(INDUCES) 21791614; 28473657 2 0 0 Enhanced cell survival +CCNE2 CCNE2 Activator; Cell cycle regulation O96020 9134 8q22.1 human T74-p 5996402 SPCIIIEtPHKEIGT protein degradation; ubiquitination 19084516 1 3 4 +CAMK2G CAMK2G EC 2.7.11.17; KINASE; Kinase, protein; Protein kinase, CAMK; Protein kinase, Ser/Thr (non-receptor) Q13555 818 10q22.2 human S334-p 4770259 GGVKKRKsSSSVHLM intracellular localization 25303525 1 2 1 dephosphorylation of S334 of CaMKIIG necessary for its nuclear translocation +Stat1 STAT1 DNA-binding; Transcription factor Q9QXK0 25124 9q22 rat Y701-p 447754 DDPKRTGyIKTELIS activity, induced; molecular association, regulation apoptosis, inhibited; transcription, altered DNA(INDUCES) 11309387; 14984365; 21102409 204 7 64 +CACNA1C CACNA1C Channel, calcium; Membrane protein, integral; Membrane protein, multi-pass Q13936 775 12p13.33 human S1535-p 460572 DYLTRDWsILGPHHL Ion_trans protein conformation 29123182 5 1 0 increased calcium influx through the channel +ARPC1B ARPC1B Cytoskeletal; Motility/polarity/chemotaxis O15143 10095 7q22.1 human T21-p 10349703 HAWNKDRtQIAICPN molecular association, regulation; phosphorylation cell cycle regulation; cell motility, altered; cytoskeletal reorganization ARPC2(INDUCES); ARP2(INDUCES) 14749719; 20603326 3 1 0 stimulates T288 AurA phosphorylation and its activation +Ogt OGT EC 2.4.1.255; Glycan Metabolism - O-glycan biosynthesis; O-GlcNAc TRANSFERASE; Transferase P56558 26295 Xq22 rat T444-p 31828209 EAIASYRtALKLKPD TPR_11 activity, induced; intracellular localization 24563466 1 1 0 modifies substrate specificity of OGT; induce AMPK activity +NUMA1 NuMA-1 Cell cycle regulation; Motility/polarity/chemotaxis Q14980 4926 11q13.4 human S1887-p 3196640 TRSSARRsQAGVSSG cell growth, induced; apoptosis, inhibited 23097092 1 12 35 cell proliferation increased +DNAJB2 DNAJB2 Chaperone P25686 3300 2q35 human S247-p 34505486 PASCPLDsDLSEDED molecular association, regulation 28031292 1 3 0 phosphorylation reduced its ability to bind ubiquitylated clients, and chaperone activity +Ahcyl1 AHCYL1 Amino Acid Metabolism - cysteine and methionine; EC 3.3.1.1; Hydrolase; Other Amino Acids Metabolism - selenoamino acid Q80SW1 229709 3 F2.3|3 46.83 cM mouse S77-p 467249 SSTDSYSsAASYTDS molecular association, regulation PIP4K2A(INDUCES); IP3R1(INDUCES) 16793548; 26509711 4 0 0 +H3c1 H3 DNA-binding P68433 360198 13|13 A3.1 mouse T11-p 455680 KQTARKStGGKAPRK Histone acetylation; intracellular localization DNA repair, induced; transcription, induced GCN5(INDUCES) 18243098 17 5 0 recruitment to promoters, H3-K9 acetylation +Cacna1c CACNA1C Channel, calcium; Membrane protein, integral; Membrane protein, multi-pass P22002 24239 4q42 rat Y1787-p 880751701 STFTPSSySSTGSNA CAC1F_C activity, induced 29441404 1 0 0 significantly increased the Ca2+current density of CACNA1C channels in a range of the membrane potentials +Cav2 caveolin-2 Adaptor/scaffold; Motility/polarity/chemotaxis Q2IBC5 363425 4q21 rat Y27-p 454430 SHHSVVDyTDPEKYV Caveolin molecular association, regulation; intracellular localization; phosphorylation IRS1(INDUCES) 19427337; 25667086 6 9 33 +CRYAB CRYAB Chaperone; Heat shock protein P02511 1410 11q23.1 human S19-p 447728 RPFFPFHsPSRLFDQ Crystallin activity, induced; protein degradation; molecular association, regulation; intracellular localization; activity, inhibited; protein conformation exocytosis, inhibited; apoptosis, inhibited FBXO4(INDUCES); CASP7(INDUCES); CRYAB(DISRUPTS); CASP3(INDUCES); GEMIN3(INDUCES); CASP2(DISRUPTS) 11096101; 12468532; 15511225; 16928191; 18061612; 23049853; 24023879; 26620801; 27641668; 36232565 26 16 2 +Tfap2a AP-2 alpha DNA-binding; Transcription factor P34056 21418 13 A3.3|13 20.01 cM mouse S219-p 25581601 CSVPGRLsLLSSTSK TF_AP-2 activity, induced transcription, induced 28179583 3 0 0 +CD22 CD22 Cell surface; Membrane protein, integral P20273 933 19q13.12 human Y807-p 450943 HKRQVGDyENVIPDF molecular association, regulation GRB2(INDUCES) 34526379 6 0 1 +ZEB2 ZEB2 C2H2-type zinc finger protein; DNA-binding; Motility/polarity/chemotaxis; Transcription, coactivator/corepressor O60315 9839 2q22.3 human K391-sm 3726900 QTGLLKIkTEPLDFN molecular association, regulation transcription, induced CTBP1(DISRUPTS) 16061479 1 2 0 +TNIP1 TNIP1 Transcription regulation Q15025 10318 5q33.1 human Y552-p 25790900 CGAYPYAyPPMPAMV molecular association, regulation cell adhesion, induced SELPLG(INDUCES); PIK3R1(INDUCES) 17632516 1 0 0 activation of alpha-M beta-2 integrin +Map3k12 DLK EC 2.7.11.25; KINASE; Kinase, protein; Protein kinase, Ser/Thr (non-receptor); Protein kinase, TKL Q60700 26404 15|15 F3 mouse S533-p 27447446 RNVPQKLsPHSKRPD protein stabilization 23979718 1 5 0 +GCSAM GCET2 Unknown function Q8N6F7 257144 3q13.2 human Y106-p 463673 SGNSAEEyYENVPCK HGAL activity, induced signaling pathway regulation 31362927 1 2 22 regulates B cell receptor signaling +CCR5 CCR5 GPCR, family 1; Membrane protein, integral; Membrane protein, multi-pass; Motility/polarity/chemotaxis; Receptor, GPCR; Receptor, cytokine P51681 1234 3p21.31 human Y339-p 2431400 PERASSVyTRSTGEQ phosphorylation 16809330 1 0 0 necessary for vaccina virus infection and subsequent ERK, IRS-2, and GRB2 phosphorylation +Pawr PAR-4 Apoptosis Q62627 64513 7q21 rat T155-p 456964 LREKRRStGVVNIPA apoptosis, induced; transcription, altered 15657440 3 1 31 +ESRRA ERR1 DNA-binding; Nuclear receptor; Transcription regulation P11474 2101 11q13.1 human K51-ub 1877015601 TRCLPGHkEEEDGEG protein degradation cell differentiation, inhibited 31907393 1 0 0 +IRF7 IRF7 DNA-binding; Transcription factor Q92985 3665 11p15.5 human K446-ub 4666608 SAGRPKEkSLVLVKL IRF-3 transcription, induced 18710948 1 0 0 +Mob1b MOB1B Activator; Protein kinase, regulatory subunit Q8BPB0 68473 5|5 E1 mouse T35-p 3545001 LLKHAEAtLGSGNLR Mob1_phocein activity, induced; molecular association, regulation; protein conformation LATS1(INDUCES) 27335147 3 47 34 +TBK1 TBK1 EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, Other; Protein kinase, Ser/Thr (non-receptor) Q9UHD2 29110 12q14.2 human K154-ub 15398587 EDGQSVYkLTDFGAA Pkinase molecular association, regulation; enzymatic activity, induced transcription, induced; signaling pathway regulation IKKG(INDUCES) 23028469 1 5 1 RIG-I-mediated antiviral defense and IFN-activation signaling +CDKN1B p27Kip1 Cell cycle regulation; Inhibitor; Oncoprotein; Protein kinase, regulatory subunit P46527 1027 12p13.1 human S2-gl 55595400 ______MsNVRVSNG protein degradation; intracellular localization cell cycle regulation; cell growth, induced Exportin-1(INDUCES) 27175940 1 1 0 translocated into the cytoplasm +Klf7 KLF7 C2H2-type zinc finger protein; DNA-binding Q99JB0 93691 1|1 C2 mouse K231-ac 56423806 GCRKVYTkSSHLKAH zf-C2H2 cell cycle regulation; cell growth, inhibited; transcription, induced 26930448 1 0 0 +ARHGAP33 SNX26 GAP; GAP, Rac/Rho; Vesicle O14559 115703 19q13.12 human Y406-p 465993 PLLTYQLyGKFSEAM RhoGAP activity, inhibited cell growth, altered 16777849 1 0 0 +HIF1A HIF1A Autophagy; DNA-binding; Transcription factor Q16665 3091 14q23.2 human K12-ac 25126717 GGANDKKkISSERRK protein degradation transcription, inhibited 21917920; 28319066 2 0 0 +Prkab1 AMPKB1 Autophagy; KINASE; Protein kinase, regulatory subunit P80386 83803 12q16 rat S24-p 448111 HKTPRRDsSGGTKDG intracellular localization 11171104 4 6 11 +Ikbkb IKKB EC 2.7.11.10; KINASE; Kinase, protein; Protein kinase, Other; Protein kinase, Ser/Thr (non-receptor) O88351 16150 8|8 A2 mouse Y188-p 449632 SFVGTLQyLAPELLE Pkinase phosphorylation; enzymatic activity, induced cell differentiation, induced; signaling pathway regulation 20534585; 30514903 6 0 0 Y188/199 of IKK? and Y179 TBK1 phosphorylation induce activation of TLR signaling; osteoclast differentiation +Ncam1 NCAM1 Cell adhesion; Membrane protein, GPI anchor; Membrane protein, integral; Motility/polarity/chemotaxis P13595 17967 9 A5.3|9 26.83 cM mouse S1113-p 456507 TQTKENEsKA_____ activity, induced 15953420 1 0 0 Phosphorylated peptide (but not unphosphorylated form) causes a larger number of transmission failures and acts as a dominant negative to the protein (similar to the null). This region of NCAM1 appears to signal through the MLCK-MLC pathway (induces MLC phosphorylation) in a putative myosin II-mediated process. +H4C1 H4 DNA-binding P62805 8359 6p22.2 human K8-ac 458959 SGRGKGGkGLGKGGA protein degradation; protein stabilization; molecular association, regulation; methylation cell cycle regulation; carcinogenesis, induced; cell growth, inhibited; apoptosis, induced; transcription, induced; transcription, altered; DNA repair, induced; cell growth, induced; chromatin organization, altered; cell differentiation, induced TBN(INDUCES); BRDT(INDUCES); CGI-09(INDUCES); BRD7(INDUCES); PUS1(INDUCES); BRD2(DISRUPTS); SETD8(DISRUPTS); THOC4(INDUCES); TAF4(INDUCES) DNA(DISRUPTS) 11387442; 15456746; 17498659; 17530637; 17560255; 18179771; 18418072; 18628788; 18985155; 19805290; 19883641; 20043883; 20048151; 20720004; 21047799; 21726812; 22978410; 23297421; 23653357; 23970329; 27508876; 31071955; 31822509; 31881804; 33087562; 35876654 85 21 529 LINC00839 promotes oxidative phosphorylation (OXPHOS), mitochondrial biogenesis and CRC progression; PRMT5 knockdow changes in the chromatin structure of all three target miRNA promoters to promote their transcription; HDACi panobinostat induced apoptosis in K562 and K562-IR cells; in acidic pH-adapted cells +MUC1 MUC1 Actin-binding; Cell adhesion; Membrane protein, integral; Motility/polarity/chemotaxis; Nuclear receptor co-regulator; Tumor suppressor P15941 4582 1q22 human S1227-p 455675 PPSSTDRsPYEKVSA molecular association, regulation CTNNB1(DISRUPTS) 9819408 1 7 17 +Grin1 NMDAR1 Channel, calcium; Channel, ligand-gated; Membrane protein, integral; Membrane protein, multi-pass P35439 24408 3p13 rat T900-p 11080321 RRRSSKDtSTGGGRG activity, inhibited 21163614 1 0 1 phosphomimetic mutations increased sensitivity to inhibition by ethanol +Csnk1d CK1D EC 2.7.11.1; EC 2.7.11.26; KINASE; Kinase, protein; Protein kinase, CK1; Protein kinase, Ser/Thr (non-receptor) Q06486 64462 10q32.3 rat S328-p 3190837 PATRGLPsTASGRLR enzymatic activity, inhibited 23861943; 26803658 2 13 1 +PLSCR3 PLSCR3 Membrane protein, integral Q9NRY6 57048 17p13.1 human T21-p 457790 PPPPYPVtPGYPEPA apoptosis, induced 16267027 1 0 1 +Sirt1 SIRT1 Apoptosis; DEACETYLASE; Deacetylase; EC 3.5.1.-; Nuclear receptor co-regulator Q923E4 93759 10|10 B4 mouse S46-p 452899 DGPGLGRsPGEPSAA protein degradation; ubiquitination 21540183 8 49 9 +SMAD1 SMAD1 DNA-binding; Transcription factor Q15797 4086 4q31.21 human S195-p 451174 PNSSYPNsPGSSSST intracellular localization 9335504 3 0 0 Erk-mediated phosphorylation inhibits the nuclear accumulation of Smad1. +DCD DCD EC 3.4.-.-; Secreted; Secreted, signal peptide P81605 117159 12q13.2 human Y20-p 18752500 AGALVCAyDPEAASA Dermcidin molecular association, regulation cell motility, altered NCK1(INDUCES) 21397687 1 0 0 +MAFA MAFA DNA-binding; Oncoprotein; Transcription factor; Tumor suppressor Q8NHW3 389692 8q24.3 human S61-p 1320401 PLSTPCSsVPSSPSF protein degradation; molecular association, regulation; ubiquitination carcinogenesis, induced; transcription, induced PCAF(INDUCES) 18042454 4 0 0 +GBF1 GBF1 GEF; GEF, ARF Q92538 8729 10q24.32 human S297-p 1170755601 TDSGLEFsSQTTSKE protein degradation; molecular association, regulation; ubiquitination; intracellular localization cell cycle regulation; cytoskeletal reorganization BTRC(INDUCES) 29898406 1 1 0 +Mapt Tau ACETYLTRANSFERASE; Acetyltransferase; Cytoskeletal P10637 17762 11 67.79 cM|11 E1 mouse S527-p 449080 VVRTPPKsPSASKSR phosphorylation neural plasticity 27834631; 33428131 45 36 25 +Siah2 SIAH2 EC 6.3.2.-; EC 6.3.2.19; Ligase; Transcription, coactivator/corepressor; UBIQUITIN LIGASE; Ubiquitin conjugating system; Ubiquitin ligase Q06986 20439 3 D|3 28.68 cM mouse S29-p 471339 PQTPHAPsPAAPPAA molecular association, regulation; intracellular localization EGLN3(INDUCES) 17003045 6 2 0 plays a role in degradation of endogenous EGLN3 (PHD3). +Ago2 AGO2 EC 3.1.26.n2; RNA processing; RNA-binding Q8CJG0 239528 15|15 D3 mouse Y394-p 17533102 ASFNTDPyVREFGIM ArgoL2 molecular association, regulation translation, induced RNA(INDUCES) 35439023 8 2 0 +EFNB2 EFNB2 Ligand, receptor tyrosine kinase; Membrane protein, integral P52799 1948 13q33.3 human Y304-p 451679 DSVFCPHyEKVSGDY molecular association, regulation; protein conformation NCK2(INDUCES) 15096211 1 22 240 Y304 phosphopeptide can also bind (simultaneously) to PDZ domain of RGS3; not phosphorylation-dependent +Tln1 talin 1 Cytoskeletal; Motility/polarity/chemotaxis P26039 21894 4|4 A5 mouse K2454-m3 40800300 DQDSEAMkRLQAAGN I_LWEQ molecular association, regulation ACTB(DISRUPTS) 25751747 2 1 0 promoted cleavage of talin +Akt1 Akt1 EC 2.7.11.1; KINASE; Kinase, protein; Oncoprotein; Protein kinase, AGC; Protein kinase, Ser/Thr (non-receptor) P31750 11651 12 F1|12 61.2 cM mouse S129-p 450019 SGSPSDNsGAEEMEV carcinogenesis, induced; signaling pathway regulation 32473126 13 48 2 FAK-p-HGFR-p-Akt-p-p65-CCL2 FAK-p-HGFR-p-Akt-p-p65-CCL2 +MAP4 MAP4 Cytoskeletal; Motility/polarity/chemotaxis P27816 4134 3p21.31 human K718-ac 62495524 KTSTSKAkTQPTSLP cytoskeletal reorganization 28002468 1 1 0 +FOXO1 FOXO1A DNA-binding; Nuclear receptor co-regulator; Oncoprotein; Transcription factor Q12778 2308 13q14.11 human S249-p 471071 EGGKSGKsPRRRAAS molecular association, regulation; intracellular localization; activity, inhibited cell cycle regulation; cell growth, induced; apoptosis, induced; apoptosis, inhibited; transcription, induced; transcription, inhibited; transcription, altered 14-3-3 beta(INDUCES) 17038621; 18356527; 18408765; 23469153; 23995784 13 2 2 +SLC4A1 SLC4A1 Membrane protein, integral; Membrane protein, multi-pass; Transporter; Transporter, SLC family P02730 6521 17q21.31 human Y21-p 457533 ENLEQEEyEDPDIPE molecular association, regulation LYN(INDUCES); ANK1(DISRUPTS) 10942405; 27856737 6 2 0 +AR AR DNA-binding; Nuclear receptor; Transcription factor P10275 367 Xq12 human R761-me 56394108 SFTNVNSrMLYFAPD Hormone_recep activity, inhibited cell growth, induced; transcription, inhibited 27183006 1 1 0 +Rims1 RIMS1 Adaptor/scaffold; Vesicle Q9JIR4 84556 9q13 rat S346-p 477744 RRLEKGRsQDYSDRP neural plasticity 35443170 1 7 1 +MARK3 MARK3 iso3 EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, CAMK; Protein kinase, Ser/Thr (non-receptor) P27448-3 4140 14q32.32-q32.33 human T95-p 3597305 DKTQLNPtSLQKLFR Pkinase enzymatic activity, inhibited 15319445 1 0 0 +TUBA1A TUBA1A Cytoskeletal; Motility/polarity/chemotaxis Q71U36 7846 12q13.12 human K311-me 1877356500 KCDPRHGkYMACCLL Tubulin_C molecular association, regulation; intracellular localization TFCP2(INDUCES) 32111740 1 1 0 TFCP2 recruits SETD8 to tubulin and enhances K311 methylation, while the inhibitor FQI1 inhibits TFCP2 methylation. +ACBD5 ACBD5 iso2 Lipid-binding; Membrane protein, integral Q5T8D3-2 91452 10p12.1 human S259-p 1876128608 TGIQHLTsDSDSEVY molecular association, regulation; phosphorylation VAPB(INDUCES) 35019937 1 1 0 induces phosphorylation at S269 +KHSRP KHSRP RNA-binding Q92945 8570 19p13.3 human S395-p 1876620110 DLLQSLRsGPPGPPG molecular association, regulation carcinogenesis, induced; RNA splicing, inhibited RNA(DISRUPTS) 35240233 1 1 0 +Nkx2-2 NKX2-2 Cell development/differentiation; Transcription factor P42586 18088 2 G2|2 72.63 cM mouse S199-p 51389258 MEVTPLPsPRRVAVP cell differentiation, inhibited 31932307 1 4 0 +KCNH2 Kv11.1 Channel, potassium; Membrane protein, integral; Membrane protein, multi-pass; Motility/polarity/chemotaxis Q12809 3757 7q36.1 human S890-p 3893409 RQRKRKLsFRRRTDK activity, induced; protein stabilization; intracellular localization; activity, inhibited signaling pathway regulation 10488078; 10837251; 22653970 4 0 3 +IP6K2 IHPK2 EC 2.7.4.21; Kinase, other; Motility/polarity/chemotaxis Q9UHH9 51447 3p21.31 human S356-p 18258507 AEDLEDLsEESADES IPK protein degradation; ubiquitination 21262846 1 2 0 +PTPN1 PTP1B EC 3.1.3.48; Motility/polarity/chemotaxis; PHOSPHATASE; Phosphatase; Protein phosphatase, tyrosine (non-receptor) P18031 5770 20q13.13 human Y152-p 449312 ISEDIKSyYTVRQLE Y_phosphatase molecular association, regulation INSR(INDUCES) 8999839 5 0 1 +Stk39 STLK3 EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, STE; Protein kinase, Ser/Thr (non-receptor) O88506 54348 3q21 rat S380-p 456506 VRRVPGSsGHLHKTE activity, induced 21553016 20 20 1 NKCC2 activity regulation/ increased +STAT5B STAT5B DNA-binding; Oncoprotein; Transcription factor P51692 6777 17q21.2 human K681-ac 62484403 PKDEVYSkYYTPVPC phosphorylation transcription, induced 23980167 1 0 0 increases pSTAT5B at Y699 +KLF8 KLF8 C2H2-type zinc finger protein; DNA-binding; Transcription factor O95600 11279 Xp11.21 human S48-p 56672701 EYRSNMTsPTLLDAN molecular association, regulation; protein stabilization; ubiquitination cell motility, induced; transcription, induced NEDD4(INDUCES) 27293988; 30972179 2 0 0 The phosphorylated form of KLF8 is ubiquitinated and degraded to protect the unphosphorylated form from degradation +DSP Desmoplakin Cell adhesion; Cytoskeletal; Motility/polarity/chemotaxis P15924 1832 6p24.3 human K2066-ub 52490401 IDPHRNEkLTVDSAI Plectin protein degradation 26676607 0 2 0 +GRIK2 GluR6 Channel, calcium; Channel, ligand-gated; Membrane protein, integral; Membrane protein, multi-pass Q13002 2898 6q16.3 human Y590-p 36320701 RFSPYEWyNPHPCNP Lig_chan activity, induced; receptor internalization, induced; protein conformation endocytosis, induced 25201974 1 0 0 activation of JNK3?c-Jun signaling. +ATP5F1A ATP5A1 EC 3.6.3.14; Energy Metabolism - oxidative phosphorylation; Hydrolase; Membrane protein, integral; Mitochondrial; Transporter P25705 498 18q21.1 human K506-ac 7248095 LEPSKITkFENAFLS ATP-synt_ab_C cell growth, inhibited 32002124 1 4 4 tumor growth inhibited (increased in K506/531R mutant) +Braf BRAF EC 2.7.11.1; KINASE; Kinase, protein; Oncoprotein; Protein kinase, Ser/Thr (non-receptor); Protein kinase, TKL F1M9C3 114486 4q22 rat S483-p 447804 KTLGRRDsSDDWEIP phosphorylation 26333016 15 44 87 constitutively phosphorylated +Agtr1 AT1 GPCR, family 1; Membrane protein, integral; Membrane protein, multi-pass; Receptor, GPCR P25095 24180 17p12 rat Y319-p 448745 YFLQLLKyIPPKAKS activity, induced; molecular association, regulation EGFR(INDUCES) 12522132 5 0 0 AT1-EGFR interaction is inhibited by dominant negative SHP-2. Y319 phosphorylation increased angiotensin II induced proliferation. +FMNL2 FMNL2 Cytoskeletal Q96PY5 114793 2q23.3 human T202-p 4689209 HSALRYNtLPSRRTL cytoskeletal reorganization 25456499 1 6 1 spine development +Frs2 FRS2 Adaptor/scaffold Q8C180 327826 10|10 D2 mouse Y436-p 448154 LEHRQLNyIQVDLEG molecular association, regulation SHP-2(INDUCES) 9632781 6 1 0 +EMD emerin Cytoskeletal; Membrane protein, integral P50402 2010 Xq28 human Y19-p 10897601 LTTLLRRyNIPHGPV LEM molecular association, regulation BAF(INDUCES) 19789182 1 1 0 +Grin1 NMDAR1 Channel, calcium; Channel, ligand-gated; Membrane protein, integral; Membrane protein, multi-pass P35438 14810 2 A3|2 17.14 cM mouse S897-p 448256 SFKRRRSsKDTSTGG neural plasticity; signaling pathway regulation 33301817 27 0 0 A2aR-PKA-Rap1-MAPK signaling pathway +PTPN6 SHP-1 EC 3.1.3.48; Motility/polarity/chemotaxis; PHOSPHATASE; Protein phosphatase, tyrosine (non-receptor) P29350 5777 12p13.31 human Y564-p 448912 SKHKEDVyENLHTKN molecular association, regulation; enzymatic activity, induced cell adhesion, inhibited; transcription, inhibited; signaling pathway regulation SH3BP2(INDUCES); GRB2(INDUCES); PIK3R1(INDUCES) 10488096; 12468540; 14551136; 14699166; 16649996; 34010642 18 19 776 +NIFK NIFK Nucleolus; RNA-binding Q9BYG3 84365 2q14.3 human T238-p 449333 QGPTPVCtPTFLERR hNIFK_binding molecular association, regulation KI-67(INDUCES) 11342549 2 27 75 +PDHA1 PDHA1 Amino Acid Metabolism - valine, leucine and isoleucine biosynthesis; Carbohydrate Metabolism - butanoate; Carbohydrate Metabolism - citrate (TCA) cycle; Carbohydrate Metabolism - glycolysis and gluconeogenesis; Carbohydrate Metabolism - pyruvate; EC 1.2.4.1; Mitochondrial; Oxidoreductase P08559 5160 Xp22.12 human K321-ac 461155 SDPIMLLkDRMVNSN E1_dh molecular association, regulation; phosphorylation cell growth, induced PDK1(INDUCES) 24486017; 25104357 2 10 74 glycolysis, cancer cell proliferation ; induces phosphorylation at S293 +SP1 SP1 C2H2-type zinc finger protein; DNA-binding; Transcription factor P08047 6667 12q13.13 human S59-p 452233 GGQESQPsPLALLAA O-GlcNAc glycosylation; protein degradation; molecular association, regulation; ubiquitination; intracellular localization cell motility, induced; transcription, inhibited; transcription, altered RNF4(INDUCES) DNA(INDUCES) 17049555; 18239466; 19318349; 21097497; 28574228; 35124373 6 16 0 negatively controls SP1 glycosylation; nuclear localization, promotes EMT; regulates cellular senescence; decreases SP1 association with chromatin; increased PPP2CA amounts in SLE T cells mediate S59-dephosphorylation and functional activation of SP1 +PPARGC1A PGC-1 alpha Nuclear receptor co-regulator; Transcription, coactivator/corepressor Q9UBK2 10891 4p15.2 human T263-p 448241 TTLSLPLtPESPNDP protein stabilization 11741533 2 0 0 +Hdac6 HDAC6 DEACETYLASE; Deacetylase; EC 3.5.1.98; Nuclear receptor co-regulator; Ubiquitin conjugating system XP_228753 84581 Xq12 rat S21-p 453006 KSRHNPQsPLQDSSA enzymatic activity, induced 20520769 5 35 18 +Mapk8ip1 JIP1 Adaptor/scaffold Q9WVI9 19099 2|2 E1 mouse Y278-p 234613501 LEATEEIyLTPVQRP molecular association, regulation VAV1(INDUCES) 28930674 1 0 0 +FOXO4 FOXO4 DNA-binding; Oncoprotein; Transcription factor P98177 4303 Xq13.1 human S262-p 448517 TFRPRSSsNASSVST intracellular localization transcription, inhibited 10217147; 11313479 5 0 2 +Scn5a SCN5A Channel, sodium; Membrane protein, integral; Membrane protein, multi-pass Q9JJV9 20271 9 F3|9 71.33 cM mouse S571-p 27281507 PWPLRRPsTQGQPGF Na_trans_cytopl activity, induced; enzymatic activity, induced 24812278; 26187182; 31622781 10 4 0 Induce and regulate Atrial fibrillation, increase calcium mediated arrhythmia and regulates atrial myocyte late Na current and membrane excitability +Ppp2r1a PPP2R1A Motility/polarity/chemotaxis; PHOSPHATASE; Protein phosphatase, regulatory subunit Q5XI34 117281 1q12 rat S314-p 31006102 KEFCENLsADCRENV molecular association, regulation; protein conformation PPP2CA(DISRUPTS) 24465463 1 1 0 defect in holoenzyme assembly +IGFBP3 IGFBP3 Cell development/differentiation; Secreted; Secreted, signal peptide P17936 3486 7p12.3 human S194-p 10902818 KVDYESQsTDTQNFS phosphorylation apoptosis, altered 19556345 1 0 0 inhibits JNK phosphorylation and apoptosis +Nfatc1 NFAT2 DNA-binding; Transcription factor O88942 18018 18 E3|18 53.66 cM mouse K549-ac 25350100 NSDIELRkGETDIGR RHD_DNA_bind activity, induced; molecular association, regulation transcription, induced DNA(INDUCES) 21498542 1 0 0 +Atoh1 ATOH1 Cell development/differentiation; DNA-binding; Transcription factor P48985 11921 6 C1|6 30.03 cM mouse S339-p 34425603 HRSDGEFsPHSHYSD protein stabilization; molecular association, regulation transcription, inhibited HUWE1(INDUCES) 24960692 2 2 0 +UBA52-RPS27A-UBB-UBC ubiquitin Ubiquitin-like modifier P62991 mouse K48-ub 486303 QRLIFAGkQLEDGRT ubiquitin protein degradation; molecular association, regulation; protein stabilization; ubiquitination cell differentiation, inhibited; autophagy, induced; transcription, inhibited ALDH2(INDUCES) 29263902; 31061531; 31076723; 31270148; 31534008; 32024978; 33976225; 34039738; 35354308; 35900990; 36261549 109 50 157 USP22 promotes the degradation of NLRP3 via ATG5-mediated autophagy; K48 linked polyubiquitylation +Ermn ERMN Q5EBJ4 77767 2 C1.1|2 mouse T257-p 2049017 NSYSRYNtISYRKIR Ermin cytoskeletal reorganization 25456499 2 3 3 spine development +PARP1 PARP1 DNA repair, damage; EC 2.4.2.30; Nuclear envelope; Nuclear receptor co-regulator; Nucleolus; Transferase P09874 142 1q42.12 human K949-ac 36310561 PKGKHSVkGLGKTTP PARP protein stabilization DNA repair, induced 31616951 1 1 0 MORC2-mediated stabilization of PARP1 is implicated in PAR-dependent DNA repair. +YAP1 YAP1 iso3 Oncoprotein; Transcription, coactivator/corepressor P46937-3 10413 11q22.1 human S127-p 448847 PQHVRAHsSPASLQL intracellular localization 27013234; 34697383; 35015027 207 33 180 +Vax2 VAX2 DNA-binding; Transcription factor Q9WTP9 24113 6 C3|6 35.94 cM mouse S170-p 470130 RDLEKRAsSSASEAF intracellular localization 17043310 1 0 0 causes relocalization of Vax2 to cytoplasm; controls eye developement in mice +H4C1 H4 DNA-binding P62805 8359 6p22.2 human S47-p 449870 RGGVKRIsGLIYEET CENP-T_C molecular association, regulation chromatin organization, altered CAF-1A(DISRUPTS); ASF1B(INDUCES); DAXX(INDUCES); H3F3A(INDUCES); HIST3H3(INDUCES); ASF1A(INDUCES); HIRA(INDUCES) DNA(INDUCES) 21724829 3 70 0 +Npy1r NPY1R GPCR, family 1; Membrane protein, integral; Membrane protein, multi-pass; Receptor, GPCR P21555 29358 16p14 rat T353-p 2815304 YETIAMStMHTDVSK receptor desensitization, altered; receptor internalization, altered 15576634 1 0 1 may be an artifact of the truncation mutants +SIAH1 SIAH1 Apoptosis; Cell development/differentiation; EC 6.3.2.-; EC 6.3.2.19; Ligase; Motility/polarity/chemotaxis; UBIQUITIN LIGASE; Ubiquitin conjugating system; Ubiquitin ligase Q8IUQ4 6477 16q12.1 human T74-p 36694103 PKLTCCPtCRGPLGS molecular association, regulation; acetylation; intracellular localization signaling pathway regulation GAPDH(INDUCES) 25391652 1 0 0 augments p300 acetylation; nuclear translocation +PDC phosducin G protein regulator, misc. P19632 287007 cow K33-sm 2873900 INDWRKFkLESEDSD Phosducin protein stabilization; molecular association, regulation; ubiquitination signaling pathway regulation G-beta 4(DISRUPTS) 16421094 1 0 0 inhibits ubiquitination, regulates binding of G-beta-gamma to phosducin and G-protein-mediated signal transduction +PPP1R14A PPP1R14A Inhibitor; Protein phosphatase, regulatory subunit Q96A00 94274 19q13.2 human S12-p 10294800 RLGKRVLsKLQSPSR PP1_inhibitor intracellular localization 23541585 2 0 0 +PCGF1 PCGF1 EC 6.3.2.-; Ubiquitin conjugating system Q9BSM1 84759 2p13.1 human S195-p 2897400 QNKYVRCsVRAEVRH RAWUL transcription, inhibited 15620699 1 1 0 +MYC Myc DNA-binding; Nucleolus; Oncoprotein; Transcription factor P01106 4609 8q24.21 human Y89-p 17553985 SGLCSPSyVAVTPFS Myc_N intracellular localization cell growth, induced 23318434 2 1 0 pY74 is localized to the cytoplasm, and is critical for maximal Myc activity in cellular transformation. +Maf MAF Cell development/differentiation; DNA-binding; Oncoprotein; Transcription factor; Tumor suppressor P54843 17132 8 E1|8 62.61 cM mouse Y21-p 25673104 TSPLAMEyVNDFDLM molecular association, regulation transcription, induced DNA(INDUCES) 25993510 2 0 0 IL-4 and IL-21 induction +SLBP SLBP RNA-binding Q14493 7884 4p16.3 human S20-p 470507 SRCDGDAsPPSPARW protein degradation; ubiquitination 22907757 1 30 25 +DTYMK DTYMK EC 2.7.4.9; Kinase, other; Mitochondrial; Nucleotide Metabolism - pyrimidine P23919 1841 2q37.3 human S88-p 1253766700 PLIKEKLsQGVTLVV Thymidylate_kin molecular association, regulation; intracellular localization DNA repair, induced Tip60(INDUCES) DNA(INDUCES) 30199284 1 1 0 +TOP2B TOP2B iso2 Cell development/differentiation; DNA-binding; EC 5.99.1.3; Motility/polarity/chemotaxis; Nucleolus; Topoisomerase Q02880-2 7155 3p24.2 human S1134-p 34733062 SSDSGTPsGPDFNYI DNA_topoisoIV protein degradation; molecular association, regulation; ubiquitination carcinogenesis, induced BTRC(INDUCES) 32015321 1 1 1 +HIF1A HIF1A Autophagy; DNA-binding; Transcription factor Q16665 3091 14q23.2 human K532-ac 458961 SDMVNEFkLELVEKL protein degradation; molecular association, regulation; ubiquitination carcinogenesis, inhibited; cell motility, inhibited; transcription, inhibited VHL(INDUCES) DNA(INDUCES) 12464182; 14695184; 18574470; 20194889; 28534506 8 2 0 +TUBG1 TUBG1 Cytoskeletal; Motility/polarity/chemotaxis P23258 7283 17q21.2 human K48-ub 486349 ATEGTDRkDVFFYQA Tubulin cell cycle regulation; cytoskeletal reorganization 15367667; 16166645 2 4 0 +CD8A CD8A iso2 Membrane protein, integral P01732-2 925 2p11.2 human K190-ub 52485006 PVVKSGDkPSLSARY protein degradation 26676607 0 1 0 +HNRNPK hnRNP K RNA splicing; RNA-binding; Spliceosome P61978 3190 9q21.32 human R268-m2 26358525 FDRMPPGrGGRPMPP molecular association, regulation translation, inhibited RPS19(INDUCES) 33660773 1 3 1 suppression of ALOX15 mRNA translation initiation +Cav2 caveolin-2 Adaptor/scaffold; Motility/polarity/chemotaxis Q2IBC5 363425 4q21 rat Y19-p 450198 LFMADDAySHHSVVD Caveolin molecular association, regulation; intracellular localization; phosphorylation cell cycle regulation ERK2(INDUCES); ERK1(INDUCES); IRS1(INDUCES) 19427337; 19778377; 25667086 10 10 28 in response to insulin +KATNA1 KATNA1 EC 3.6.4.3; Hydrolase; Motility/polarity/chemotaxis O75449 11104 6q25.1 human S42-p 26401200 QMNKYLYsVKDTYLQ ubiquitination cell cycle regulation 19287380 1 0 0 +Bmpr1a BMPR1A EC 2.7.11.30; KINASE; Kinase, protein; Membrane protein, integral; Protein kinase, Ser/Thr (receptor); Protein kinase, TKL P36895 12166 14 B|14 20.81 cM mouse Y458-p 25655002 EEYQLPYyNMVPSDP PK_Tyr_Ser-Thr molecular association, regulation cell growth, induced; signaling pathway regulation BMPR2(INDUCES); TAB1(DISRUPTS) 22729085 1 1 0 regulation of BMP downstream pathways-Erk1/2 and Smad1 activation, regulates life span of osteoblasts (expansion) +HSPA5 GRP78 Chaperone; Heat shock protein; KINASE P11021 3309 9q33.3 human K118-ac 475591 DIKFLPFkVVEKKTK HSP70 molecular association, regulation; phosphorylation apoptosis, induced; signaling pathway regulation PERK(DISRUPTS) 20371724 1 2 0 induces phosphorylation of elf2a and activation of eIf2a-ATF4-CHOP pathway +TBX22 TBX22 DNA-binding Q9Y458 50945 Xq21.1 human K63-sm 2798305 EPLEKQPkTEPSTSA transcription, inhibited 17846996 1 0 0 +BECN1 beclin 1 Adaptor/scaffold; Autophagy; Membrane protein, peripheral Q14457 8678 17q21.31 human Y233-p 477225 EAQYQREySEFKRQQ APG6_N molecular association, regulation cell differentiation, inhibited; carcinogenesis, induced; autophagy, inhibited Bcl-2(INDUCES); ATG14(DISRUPTS); beclin 1(INDUCES); UVRAG(INDUCES); rubicon(INDUCES); PIK3C3(DISRUPTS) 24034250; 27994061; 29610308 3 0 0 kinase active HER2 +Mfn1 MFN1 EC 3.6.5.-; Hydrolase; Membrane protein, integral; Membrane protein, multi-pass; Mitochondrial Q8R4Z9 192647 2q24 rat T562-p 40416800 VPRSLAStPTAPSNP molecular association, regulation apoptosis, induced BAK1(INDUCES); MFN1(DISRUPTS) 25801171 1 0 0 inhibits its own oligomerization; modulate mitochondrail shape +Tp53 p53 Activator; DNA-binding; Motility/polarity/chemotaxis; Nuclear receptor co-regulator; Transcription factor; Tumor suppressor P02340 22059 11 B3|11 42.83 cM mouse K378-ac 458983 GQSTSRHkKTMVKKV activity, induced transcription, induced 33323382 35 6 0 P53K Q/- mice died prematurely due to anemia, loss of hematopoiesis stem cells, Loss of stem cells in the testis, activation in p53 KQ/- mice without robust p53 stabilization,p53-KQ/- mutant leads to effective suppression of tumor development in a pancreatic ductal adenocarcinoma mouse model, mutant proteins extended the life-span of a PDAC mouse model +RAB5B RAB5B G protein; G protein, monomeric; G protein, monomeric, Rab P61020 5869 12q13.2 human T6-p 38546301 __MTSRStARPNGQP activity, induced cell growth, induced 25605758 1 1 0 enhances Rab5 GTPase activity +Lpin1 LPIN1 EC 3.1.3.4; Phosphatase, lipid Q91ZP3 14245 12 A1.1|12 7.9 cM mouse S472-p 471355 GARSANQsPQSVGGS intracellular localization chromatin organization, altered; transcription, induced; signaling pathway regulation 21816276 2 7 0 SREBP pathway, regulates nuclear eccentricity +ACTB ACTB Cytoskeletal; Motility/polarity/chemotaxis P60709 60 7p22.1 human H73-me 1877656601 TLKYPIEhGIVTNWD Actin protein conformation 30760599 2 0 0 Methyl-H73 N+-H interaction with the side chain of R177 which allows the gamma-phosphate to escape +WWTR1 TAZ Oncoprotein; Transcription, coactivator/corepressor Q9GZV5 25937 3q25.1 human T285-p 41594200 AVNPPTMtPDMRSIT protein degradation 26183396 1 0 0 +Rcan1 RCAN1 Inhibitor Q6IN33 266766 11q11 rat S112-p 456023 FLISPPAsPPVGWKQ Calcipressin enzymatic activity, induced neural plasticity 32084406 7 38 6 induces calcineurin activity and hence LTD +APC APC Motility/polarity/chemotaxis; Tumor suppressor P25054 324 5q22.2 human S1507-p 452097 FSCSSSLsALSLDEP APC_r molecular association, regulation; phosphorylation CTNNB1(INDUCES) 12628243; 17910481 2 0 0 primes for phosphorylation of S1510 and S1507, by CK1 and GSK3B respectively; based on acidic phospho-mimetic mutant +LIN28B LIN28B Unknown function Q6ZN17 389421 6q16.3-q21 human S243-p 1870790709 EQSKKGPsVQKRKKT molecular association, regulation; intracellular localization carcinogenesis, induced; cell motility, induced; cell growth, induced; transcription, induced; signaling pathway regulation RNA(INDUCES) 33107691 1 0 0 induces binding to let-7i miRNA thus inducing the let-7/TET3 pathway +NFE2L2 NRF2 DNA-binding; Transcription factor Q16236 4780 2q31.2 human K548-ac 7106314 KEKGENDkSLHLLKK bZIP_Maf molecular association, regulation transcription, induced DNA(INDUCES) 19273602 1 1 0 +FOS Fos DNA-binding; Motility/polarity/chemotaxis; Oncoprotein; Transcription factor P01100 2353 14q24.3 human S374-p 448482 PSSDSLSsPTLLAL_ protein stabilization; molecular association, regulation; phosphorylation; enzymatic activity, induced cell cycle regulation; carcinogenesis, induced; cell motility, induced; cell growth, induced; transcription, induced FBXL10(DISRUPTS) 23667255; 26725323; 32075732; 35439648 12 3 0 +G6PD G6PD Carbohydrate Metabolism - pentose phosphate pathway; Cell development/differentiation; EC 1.1.1.49; Other Amino Acids Metabolism - glutathione; Oxidoreductase P11413 2539 Xq28 human K89-ac 11320983 KQSEPFFkATPEEKL G6PD_N protein conformation; enzymatic activity, induced; enzymatic activity, altered 37798264 1 4 0 ubiquitylation of adjacent K95/K97; lowers the thermodynamic stability of G6PD +OPRM1 MOR-1 GPCR, family 1; Membrane protein, integral; Membrane protein, multi-pass; Receptor, GPCR P35372 4988 6q25.2 human T396-p 448128 LENLEAEtAPLP___ receptor desensitization, inhibited 24304623 5 0 0 DAMGO-induced desensitization +CERS6 LASS6 DNA-binding; Membrane protein, integral; Membrane protein, multi-pass Q6ZMG9 253782 2q24.3 human S341-p 40511820 KVSKDDRsDIESSSD enzymatic activity, induced 26887952 1 1 0 +DVL2 DVL2 Adaptor/scaffold; Motility/polarity/chemotaxis O14641 1856 17p13.1 human T595-p 27623903 GSRSSGStRSDGGAG Dsh_C cytoskeletal reorganization; transcription, inhibited 23396967 1 0 0 neurite outgrowth +Map3k7 TAK1 EC 2.7.11.25; KINASE; Kinase, protein; Protein kinase, Ser/Thr (non-receptor); Protein kinase, TKL P0C8E4 313121 5q21 rat T187-p 454704 CDIQTHMtNNKGSAA PK_Tyr_Ser-Thr enzymatic activity, induced cell cycle regulation; autophagy, induced; cell motility, induced; cell growth, induced 35078016 33 1 0 +Cbx5 HP1 alpha Transcription, coactivator/corepressor Q61686 12419 15|15 F3 mouse S11-p 476162 KTKRTADsSSSEDEE molecular association, regulation H3(INDUCES) DNA(INDUCES) 21245376 1 26 2 important for chromosomal stability +HSP90AB1 HSP90B Chaperone; Heat shock protein P08238 3326 6p21.1 human S718-p 3177650 LEGDEDAsRMEEVD_ protein stabilization; molecular association, regulation carcinogenesis, induced; cell growth, induced HOPX(INDUCES); CHIP(DISRUPTS) 22824801 3 9 0 cell proliferation increased +BCL10 Bcl-10 Apoptosis; Transcription, coactivator/corepressor; Tumor suppressor O95999 8915 1p22.3 human S138-p 470125 NNLSRSNsDESNFSE activity, induced; phosphorylation cell motility, altered; cytoskeletal reorganization; signaling pathway regulation; transcription, altered 17371994; 20466000; 21199863; 21674474; 21700900 7 30 18 PPP3CA-regulated NF-kB activation pathway +Cd79a Ig-alpha Immunoglobulin superfamily; Membrane protein, integral P11911 12518 7 A3|7 13.49 cM mouse Y176-p 447751 GVDMPDDyEDENLYE molecular association, regulation; intracellular localization GRB2(INDUCES); BLNK(INDUCES); VAV1(INDUCES) 11859098 6 2 4 +RUNX1 AML1 DNA-binding; Oncoprotein; Transcription factor Q01196 861 21q22.12 human K24-ub 15384407 STALSPGkMSEALPL protein degradation; intracellular localization carcinogenesis, inhibited; cell growth, inhibited; transcription, inhibited 28536267 1 3 1 +XKR5 XKR5 Membrane protein, integral; Membrane protein, multi-pass Q6UX68 389610 8p23.1 human Y543-p 1172732403 GQQSSTLyFSATAEV phosphorylation carcinogenesis, inhibited; cell growth, inhibited; signaling pathway regulation 29910466 1 1 0 inhibits phosphorylation of ERK, AKT and p38 +G3BP1 G3BP-1 Adaptor/scaffold; EC 3.6.4.12; EC 3.6.4.13; Helicase; RNA-binding Q13283 10146 5q33.1 human R460-m1 476717 KPGFGVGrGLAPRQ_ translation, altered 27601476 1 7 72 inhibits Stress Granules (SGs)-RNA granule assembly upon environmental stress +NF2 Merlin Cytoskeletal; Motility/polarity/chemotaxis; Tumor suppressor P35240 4771 22q12.2 human K364-ub 27197394 ERRLLQMkEEATMAN ERM_helical molecular association, regulation; intracellular localization LATS1(DISRUPTS) 30918126 1 4 0 K63 kinked +H3C1 H3 DNA-binding P68431 8350 6p22.2 human K36-m3 1458608 APATGGVkKPHRYRP Histone protein degradation; molecular association, regulation; acetylation; intracellular localization cell cycle regulation; DNA repair, induced; chromatin organization, altered; transcription, induced; transcription, inhibited; transcription, altered MSH6(INDUCES); PHF1(INDUCES); WHSC1(INDUCES); NSD1(INDUCES); PALB2(INDUCES); MORF4L1(INDUCES); N-PAC(INDUCES) DNA(INDUCES) 16732292; 18923077; 19021773; 19521516; 19935671; 20093418; 20139424; 20850016; 23273982; 26602815; 27476967; 28648780; 28663576; 28673974; 28753426 65 11 4 +Appl1 APPL Adaptor/scaffold; Nuclear receptor co-regulator Q8K3H0 72993 14|14 A3 mouse S401-p 449251 ALEAVTPsPSFQQRH molecular association, regulation; phosphorylation signaling pathway regulation IRS2(DISRUPTS); INSR(INDUCES); IRS1(DISRUPTS) 24813896 2 42 0 regulates phosphorylation IRS1/2, AKT and GSK3B, promotes insulin signaling, PI3K signaling pathway +FOXO1 FOXO1A DNA-binding; Nuclear receptor co-regulator; Oncoprotein; Transcription factor Q12778 2308 13q14.11 human S218-p 4258805 NSIRHNLsLHSKFIR Forkhead molecular association, regulation DNA(DISRUPTS) 18786403 1 2 0 +VHL VHL Tumor suppressor; UBIQUITIN LIGASE; Ubiquitin ligase P40337 7428 3p25.3 human S72-p 469117 SVNSREPsQVIFCNR VHL molecular association, regulation cell cycle regulation; carcinogenesis, induced; cytoskeletal reorganization HIF2A(DISRUPTS) 16847331; 23785518 3 1 0 +CDC14A CDC14A EC 3.1.3.16; EC 3.1.3.48; Motility/polarity/chemotaxis; PHOSPHATASE; Protein phosphatase, dual-specificity Q9UNH5 8556 1p21.2 human S411-p 25733761 SQRQPRTsPSCAFRS molecular association, regulation 30089874 1 1 1 interaction with putative unknown substrates or regulators +IRF7 IRF7 DNA-binding; Transcription factor Q92985 3665 11p15.5 human S477-p 1276101 VSSLDSSsLSLCLSS activity, induced; molecular association, regulation; intracellular localization; protein conformation transcription, induced H4(DISRUPTS) 10893229; 25225665 5 0 0 +KLF13 KLF13 C2H2-type zinc finger protein; DNA-binding Q9Y2Y9 51621 15q13.3 human K226-ac 460602 RTHTGEKkFSCPICE molecular association, regulation transcription, induced DNA(DISRUPTS) 12758070 1 0 0 +MCM7 MCM7 DNA replication; EC 3.6.4.12; Motility/polarity/chemotaxis P33993 4176 7q22.1 human K449-m1 58123402 CCIDEFDkMAEADRT MCM molecular association, regulation L3MBTL iso4(INDUCES) 23583077 0 1 0 +TERF1 TRF1 DNA-binding P54274 7013 8q21.11 human T371-p 3727647 VSKSQPVtPEKHRAR protein stabilization; molecular association, regulation; intracellular localization; phosphorylation cell cycle regulation; carcinogenesis, induced; DNA repair, induced; chromatin organization, altered; apoptosis, induced H2AX(INDUCES); 53BP1(INDUCES) DNA(INDUCES); DNA(DISRUPTS) 18625707; 21712819; 23997120; 27185864; 36140400 5 6 8 +SIRT3 SIRT3 DEACETYLASE; Deacetylase; EC 3.5.1.-; Mitochondrial Q9NTG7 23410 11p15.5 human Y226-p 1881476100 KGLLLRLyTQNIDGL enzymatic activity, inhibited 34289383 1 0 0 +POLI POLI DNA repair, damage; EC 2.7.7.7; Transferase Q9UNA4 11201 18q21.2 human K513-ub 50771301 TTNFSKEkDINEFPL protein degradation 26370087 1 2 0 +KLF3 KLF3 C2H2-type zinc finger protein; DNA-binding; Transcription factor P57682 51274 4p14 human K198-sm 3617603 PISQKKIkIEPGIEP molecular association, regulation transcription, inhibited 15684403 1 2 0 +TEK TIE2 EC 2.7.10.1; KINASE; Kinase, protein; Membrane protein, integral; Protein kinase, TK; Protein kinase, tyrosine (receptor) Q02763 7010 9p21.2 human Y992-p 448373 LSRGQEVyVKKTMGR PK_Tyr_Ser-Thr activity, induced; protein conformation 25320242; 28396439 7 0 0 +CHEK1 Chk1 EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, CAMK; Protein kinase, Ser/Thr (non-receptor); Tumor suppressor O14757 1111 11q24.2 human T378-p 1388511401 QRLVKRMtRFFTKLD protein degradation; enzymatic activity, induced cell cycle regulation 30510197 1 0 0 +Cttn Cortactin Actin-binding; Cytoskeletal; Motility/polarity/chemotaxis NP_001385572 60465 1q41-q42 rat Y466-p 447703 AYTSEPVyETTEVPG cell adhesion, altered 15383621 32 3 10 +Exoc8 EXOC8 Vesicle O54924 245709 19q12 rat S93-p 182950101 LLTEQKSsLESIPLA Vps51 molecular association, regulation exocytosis, inhibited Sec5(DISRUPTS); EXOC8(DISRUPTS) 28325821 1 1 0 +HSF1 HSF1 DNA-binding; Transcription factor Q00613 3297 8q24.3 human T527-p 1876167504 PPKAKDPtVS_____ Vert_HS_TF activity, induced; molecular association, regulation transcription, induced CDK9(INDUCES); GTF2B(INDUCES) 35080342 1 1 0 +YWHAZ 14-3-3 zeta Adaptor/scaffold; Motility/polarity/chemotaxis P63104 7534 8q22.3 human S64-p 10407031 SSWRVVSsIEQKTEG 14-3-3 activity, induced; molecular association, regulation; intracellular localization transcription, induced AR(INDUCES) DNA(INDUCES) 34697370 1 6 1 +KCNMA1 KCNMA1 Channel, potassium; Endoplasmic reticulum; Membrane protein, integral; Membrane protein, multi-pass Q28204 282573 cow S695-p 456596 DEQPSTLsPKKKQRN activity, inhibited 20385812 1 20 0 +H3C1 H3 DNA-binding P68431 8350 6p22.2 human K4-ac 10306116 ____ARTkQTARKST Histone cell cycle regulation; carcinogenesis, induced; carcinogenesis, inhibited; apoptosis, induced; transcription, induced; signaling pathway regulation 20546607; 26783963; 28068431 16 2 9 CIL-102 activation of the JNK1/2 pathway and p300/CBP acetylation of H3K4 +Gorasp2 GRASP55 Motility/polarity/chemotaxis; Vesicle Q9R064 113961 3q22 rat S245-p 12654012 SVSPPSLsPPGTAGV molecular association, regulation cytoskeletal reorganization GRASP55(DISRUPTS) 20083603 1 0 5 inhibits Golgi stack formation in interphase cells and enhances Golgi fragmentation in mitotic cells +Cacng2 Stargazin Channel, calcium; Membrane protein, integral; Membrane protein, multi-pass Q71RJ2 84347 7q34 rat S253-p 455307 PSHSRDAsPVGVKGF molecular association, regulation neural plasticity PSD-95(INDUCES) 25843401 3 7 0 +Plekhg5 PLEKHG5 Q66T02 269608 4|4 E2 mouse S92-p 27528601 SVLARNVsTRSCPPR molecular association, regulation; intracellular localization; enzymatic activity, inhibited cytoskeletal reorganization; cell adhesion, inhibited 14-3-3 beta(INDUCES); RHOA(DISRUPTS); 14-3-3 zeta(INDUCES); 14-3-3 epsilon(INDUCES); 14-3-3 gamma(INDUCES) 23335514 1 2 0 inhibits targeting to cell border +MYC Myc DNA-binding; Nucleolus; Oncoprotein; Transcription factor P01106 4609 8q24.21 human T373-p 450960 EENVKRRtHNVLERQ HLH molecular association, regulation carcinogenesis, inhibited; cell differentiation, induced; transcription, induced MAX(DISRUPTS) DNA(INDUCES); DNA(DISRUPTS) 22020439; 26678338 6 0 0 repression of YAP/TAZ activity +ARID4A RbBP1 Adaptor/scaffold P29374 5926 14q23.1 human S864-p 14578923 RKILGQSsPEKKIRI molecular association, regulation Rb(DISRUPTS) 21148318 1 31 0 +PRMT5 PRMT5 Cell cycle regulation; EC 2.1.1.125; METHYLTRANSFERASE; Methyltransferase; Methyltransferase, protein arginine; RNA processing O14744 10419 14q11.2 human T80-p 62906108 LSGRDWNtLIVGKLS PRMT5_TIM methylation; enzymatic activity, induced 28074910; 36232624 2 0 0 induces H4 methylation +KCNN4 KCNN4 Channel, potassium; Membrane protein, integral; Membrane protein, multi-pass O15554 3783 19q13.31 human S334-p 452145 KHTRRKEsHAARRHQ CaMBD activity, inhibited Calmodulin(DISRUPTS) 25274816 3 0 0 inhibits channel current, inhibits Ca++ influx +RNF20 RNF20 EC 6.3.2.-; EC 6.3.2.19; Ligase; UBIQUITIN LIGASE; Ubiquitin conjugating system; Ubiquitin ligase Q5VTR2 56254 9q31.1 human S553-p 482125 QSSASKAsQEDANEI ubiquitination DNA repair, induced 21362549 1 2 0 induces H2B-K125 ubiquitylation +CDT1 CDT1 DNA replication; DNA-binding; Motility/polarity/chemotaxis; Oncoprotein Q9H211 81620 16q24.3 human S391-p 20804632 LRSAAPSsPGSPRPA protein stabilization; molecular association, regulation; activity, inhibited RAMP(DISRUPTS) 21930785 2 5 1 +Mapt Tau ACETYLTRANSFERASE; Acetyltransferase; Cytoskeletal P19332 29477 10q32.1 rat S519-p 487449 GSPGTPGsRSRTPSL molecular association, regulation 28784767 4 7 5 aggregation +ETV5 ERM DNA-binding; Transcription factor P41161 2119 3q27.2 human K293-sm 2887209 FQSPMGIkQEPRDYC ETS_PEA3_N transcription, inhibited 15857832; 18243147 2 0 0 +FTH1 Ferritin-H Cofactor and Vitamin Metabolism - porphyrin and chlorophyll; EC 1.16.3.1; Oxidoreductase P02794 2495 11q12.3 human S179-p 452608 DKHTLGDsDNES___ molecular association, regulation; intracellular localization; phosphorylation cell motility, altered CXCR4(INDUCES) 17056593 1 31 4 overexpression of S179A Ferritin-H increases them.; Overexpression of Ferritin-H reduces phospho-Erk1/2 levels +Thra TR-alpha DNA-binding; Nuclear receptor; Transcription factor P63058 21833 11 D|11 62.58 cM mouse K283-sm 27490404 LSGEMAVkREQLKNG Hormone_recep intracellular localization cell cycle regulation; cell growth, induced; transcription, induced DNA(INDUCES) 34916557 4 0 0 mutant mice had reduced fat stores on normal chow, and was reduced, more on high fat diets ; reduced CREB and AP1-mediated gene expression, reduced TR-alpha?CREB interaction in mutant preadipocytes; decreased preadipocyte proliferation, reduced white adipose stores and adipocyte cell diameter in mutant mice; (K283Q/K288R)-/- mutant: reduced nuclear localization of cyclin D1, cyclin D2, Cdk4 and Cdk2 in human primary preadipocytes +Tp63 p63 DNA-binding; Transcription factor O88898 22061 16 B1|16 17.37 cM mouse S162-p 451601 TFDALSPsPAIPSNT apoptosis, induced; signaling pathway regulation 29988075 6 2 0 +CENPQ CENPQ Q7L2Z9 55166 6p12.3 human S253-p 23092802 HNSSQMKsMSTFIEE CENP-Q molecular association, regulation; intracellular localization DNA(DISRUPTS) 25670858 1 1 1 CENPQ phosphorylation promotes the delocalization of the PBIP1-CENPQ complex from kinetochores +CDC25C CDC25C EC 3.1.3.48; Motility/polarity/chemotaxis; PHOSPHATASE; Protein phosphatase, dual-specificity P30307 995 5q31.2 human S122-p 449910 DQHLMKCsPAQLLCS cell cycle regulation; cell adhesion, altered 8119945 1 3 5 +FLNB FLNB Actin-binding; Motility/polarity/chemotaxis O75369 2317 3p14.3 human K681-ub 22244658 DAGKAPLkIFAQDGE Filamin protein degradation 26676607 0 3 0 +RNF11 RNF11 EC 6.3.2.-; Ligase; UBIQUITIN LIGASE; Ubiquitin conjugating system; Ubiquitin ligase Q9Y3C5 26994 1p32.3 human T135-p 2893400 DWLMRSFtCPSCMEP zf-RING_2 protein degradation; molecular association, regulation transcription, altered 14-3-3 gamma(INDUCES) 16123141 1 0 0 +Hnrnpf hnRNP F RNA splicing; RNA-binding; Spliceosome Q794E4 64200 4q42 rat K98-ac 15294655 TEMDWVLkHSGPNSA protein stabilization RNA splicing, induced 25959059 1 3 1 +DYNC1I2 DYNC1I2 iso3 Microtubule-binding; Motility/polarity/chemotaxis; Motor Q13409-3 1781 2q31.1 human S84-p 4033130 PPPMSPSsKSVSTPS cell motility, inhibited 24798412 3 11 2 S84D mutant retrograde movement was more likely compared to S84A mutant +ERCC3 XPB DNA repair, damage; EC 3.6.4.12; Helicase; Transcription factor P19447 2071 2q14.3 human S751-p 454425 FGTMSSMsGADDTVY activity, inhibited 15549133 2 0 0 +ARAP1 CENTD2 GAP; GAP, ARF; Motility/polarity/chemotaxis Q96P48 116985 11q13.4 human Y231-p 3209592 PEFDDSDyDEVPEEG endocytosis, altered 20554524 1 6 57 inhibits EGFR internalization +Lepr LEPR Membrane protein, integral; Receptor, cytokine P48356 16847 4 C6|4 46.96 cM mouse Y985-p 448435 QRQPSVKyATLVSND activity, induced; molecular association, regulation; activity, inhibited; phosphorylation signaling pathway regulation; transcription, altered SOCS3(INDUCES); SHP-2(INDUCES) 10449753; 10799542; 11018044; 11085989; 11108838; 15634336; 20059770; 20086094; 32348667 16 0 0 energy metabolism; attenuation of STAT3 phosphorylation; induces leptin signaling; leptin signaling +USP4 USP4 DEUBIQUITINASE; EC 3.4.19.12; Oncoprotein; Protease; Ubiquitin conjugating system; Ubiquitin-specific protease Q13107 7375 3p21.31 human S445-p 5204831 NHRLRNDsVIVDTFH UCH protein stabilization; molecular association, regulation; intracellular localization; enzymatic activity, induced signaling pathway regulation 14-3-3 sigma(INDUCES); 14-3-3 zeta(DISRUPTS); 14-3-3 eta(INDUCES) 22706160 1 3 1 +GAREM1 GAREM Adaptor/scaffold Q9H706 64762 18q12.1 human Y105-p 9721500 DIKEPVQyFNSVEEV CABIT molecular association, regulation GRB2(INDUCES) 19509291 1 0 0 activates Erk +SNIP1 SNIP1 Inhibitor Q8TAD8 79753 1p34.3 human K5-sm 59149203 ___MKAVkSERERGS molecular association, regulation cell motility, induced; transcription, induced 27703003 1 0 0 SUMOylation decreases the inhibitory effect of SNIP1 on TGF-beta-induced formation of the Smad2/4 and Smad3/4 complexes +Ncoa3 SRC-3 ACETYLTRANSFERASE; Acetyltransferase; EC 2.3.1.48; Motility/polarity/chemotaxis; Nuclear receptor co-regulator; Transcription, coactivator/corepressor O09000 17979 2|2 H3 mouse R1195-m2 2363404 QQFLNQSrQALEMKM protein degradation transcription, inhibited CBP(INDUCES) 17043108 1 1 19 +TP53 p53 Activator; DNA-binding; Motility/polarity/chemotaxis; Nuclear receptor co-regulator; Transcription factor; Tumor suppressor P04637 7157 17p13.1 human S376-p 447570 LKSKKGQsTSRHKKL activity, induced; protein degradation; molecular association, regulation; intracellular localization; activity, inhibited cell cycle regulation; apoptosis, induced; chromatin organization, altered; apoptosis, inhibited; transcription, induced S100B(DISRUPTS); 14-3-3 zeta(DISRUPTS); 14-3-3 gamma(INDUCES); BLM(DISRUPTS); S100A2(DISRUPTS); 14-3-3 beta(DISRUPTS); WRN(DISRUPTS) DNA(INDUCES) 11007451; 11585729; 12080066; 14744935; 16227590; 17898864; 19819244; 34798143; 9315650; 9620776 13 0 0 arsenic induced overexpression of PUMA, P53 phosphorylation and acetylation, activation and accumulation of p53, PUMA disruption of Bcl-X complexes with pro-survival proteins resulting in apoptosis +RPS6KA1 p90RSK EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, AGC; Protein kinase, Ser/Thr (non-receptor); Translation P18652 386579 chicken S381-p 447989 TSRTPKDsPGIPPSA Pkinase_C intracellular localization; enzymatic activity, induced 11585927 42 47 4 +MAPK7 ERK5 EC 2.7.11.24; KINASE; Kinase, protein; Protein kinase, CMGC; Protein kinase, Ser/Thr (non-receptor) Q13164 5598 17p11.2 human T219-p 448205 AEHQYFMtEYVATRW Pkinase cell cycle regulation; carcinogenesis, induced; cell motility, induced; apoptosis, inhibited; transcription, induced 20138986; 31980741; 34655447 20 2 31 +CTNND1 CTNND1 Actin-binding; Adaptor/scaffold; Cell adhesion; G protein regulator, misc.; Motility/polarity/chemotaxis O60716 1500 11q12.1 human Y335-p 454928 EVPSDQYyWAPLAQH molecular association, regulation; intracellular localization CDH1(DISRUPTS) 35030104 1 9 132 +ESR1 ER-alpha DNA-binding; Nuclear receptor; Transcription factor P03372 2099 6q25.1-q25.2 human S236-p 448739 IDKNRRKsCQACRLR zf-C4 transcription, inhibited 22266331; 9891036 5 1 0 +IRS1 IRS1 Adaptor/scaffold; Motility/polarity/chemotaxis P35568 3667 2q36.3 human Y662-p 450356 QRVDPNGyMMMSPSG molecular association, regulation cell differentiation, induced; transcription, induced PIK3R1(INDUCES) 12525499 2 5 90 +Hspb1 HSP27 Chaperone; Heat shock protein; Motility/polarity/chemotaxis; SUMO LIGASE; SUMO ligase P14602 15507 5 G2|5 75.51 cM mouse S15-p 448401 FSLLRSPsWEPFRDW activity, induced; intracellular localization apoptosis, induced PKCD(NOT_REPORTED) 15731106 52 78 30 +CRYAB CRYAB Chaperone; Heat shock protein P02511 1410 11q23.1 human K92-ac 459002 SPEELKVkVLGDVIE HSP20 activity, induced; protein stabilization; molecular association, regulation; protein conformation; activity, inhibited apoptosis, inhibited CRYGA(INDUCES) 23508955; 24128140 1 7 0 Induces MDH activity; higher a?nity for denatured proteins +GDI2 GDI2 G protein regulator, misc.; Motility/polarity/chemotaxis P50395 2665 10p15.1 human S382-p 5829589 PIEQKFVsISDLLVP GDI molecular association, regulation RAB5A(INDUCES); RAB11A(INDUCES) 33914026 1 1 9 +ARHGAP24 ARHGAP24 GAP; GAP, Rac/Rho; Motility/polarity/chemotaxis Q8N264 83478 4q21.23-q21.3 human T452-p 12518705 GLEKTQTtPNGSLQA activity, induced cytoskeletal reorganization 16862148 1 1 2 membrane blebbing +Syk Syk EC 2.7.10.2; KINASE; Kinase, protein; Protein kinase, TK; Protein kinase, tyrosine (non-receptor) P48025 20963 13 A5|13 27.41 cM mouse Y290-p 448709 IISRIKSySFPKPGH intracellular localization 20956537 3 11 95 +MAFG MAFG Cell cycle regulation; DNA-binding O15525 4097 17q25.3 human K53-ac 458964 KEEIVQLkQRRRTLK bZIP_Maf molecular association, regulation DNA(INDUCES) 11154691 1 0 0 +Cdh2 CDH2 Cell adhesion; Membrane protein, integral; Motility/polarity/chemotaxis Q9Z1Y3 83501 18p13 rat S871-p 382737700 GSTAGSLsSLNSSSS CADH_Y-type_LIR intracellular localization cytoskeletal reorganization CTNNB1(INDUCES) 29133434 1 0 0 PKD1 colocalizes with N-cadherin at dendritic spines mainly in the postsynaptic compartment, long-term potentiation (LTP) induction and regulates synaptic plasticity +TUBB4B TUBB2C Cytoskeletal; Motility/polarity/chemotaxis P68371 10383 9q34.3 human K19-m1 58123405 CGNQIGAkFWEVISD Tubulin molecular association, regulation L3MBTL iso4(INDUCES) 23583077 0 1 0 +ATF6 ATF6A Membrane protein, integral; Transcription factor P18850 22926 1q23.3 human S104-p 35527101 SSSYSVSsPRSVDSY transcription, induced 25135476 1 0 0 +RAPGEF2 RAPGEF2 GEF; GEF, Ras; Motility/polarity/chemotaxis Q9Y4G8 9693 4q32.1 human S1254-p 30995202 GSWTSCSsGSHDNIQ phosphorylation 24290981 1 1 0 Phosphorylation at S1254 promotes CK1-alpha dependent phosphorylation at S1244 and S1248 +Mpc2 MPC2 Membrane protein, multi-pass; Mitochondrial Q9D023 70456 1|1 H2.2 mouse K19-ac 467165 TYHRLMDkVELLLPK protein degradation; activity, inhibited 28154187 1 5 2 inhibits pyruvate transport activity +NPFFR2 NPFFR2 GPCR, family 1; Membrane protein, integral; Membrane protein, multi-pass; Receptor, GPCR Q9Y5X5 10886 4q13.3 human T477-p 36533413 KSHVLINtSNQLVQE receptor desensitization, induced 25326382 1 1 0 +PAK6 PAK6 EC 2.7.11.1; KINASE; Kinase, protein; Nuclear receptor co-regulator; Protein kinase, STE; Protein kinase, Ser/Thr (non-receptor) Q9NQU5 56924 15q15.1 human S346-p 29666300 TGQLPGRsSPAGSPR molecular association, regulation; enzymatic activity, induced carcinogenesis, induced; cell motility, induced AR(INDUCES) 24130878 1 2 0 promotion of cell motility and invasion +NQO1 NQO1 EC 1.6.5.2; Oxidoreductase P15559 1728 16q22.1 human T128-p 1868914500 FIGEFAYtYAAMYDK Flavodoxin_2 protein degradation; molecular association, regulation; ubiquitination; enzymatic activity, inhibited; phosphorylation; enzymatic activity, induced apoptosis, induced PARK2(INDUCES) Other(DISRUPTS) 31358653; 36096178 2 1 0 repression of dopaminergic loss observed in S40A/T128A mutatnt; induces AEP activity and synuclein phosphorylation; inhibits FAD binding +Hhex HHEX DNA-binding; Transcription factor F7F7Q9 rat S153-p 7430501 LAKMLQLsERQVKTW Homeodomain cell cycle regulation; cell growth, induced 28927755 2 0 0 neointima formation ex vivo +ATG16L1 ATG16L1 iso3 Adaptor/scaffold; Autophagy; Membrane protein, peripheral Q676U5-3 55054 2q37.1 human S269-p 460725 RAATKRLsQPAGGLL protein degradation autophagy, inhibited 31580256 1 20 12 +FCRL3 FCRL3 Adaptor/scaffold; Membrane protein, integral Q96P31 115352 1q23.1 human Y692-p 469982 HEELTVLySELKKTH molecular association, regulation SHP-1(INDUCES) 12051764 1 0 0 +PDE4D PDE4D iso6 EC 3.1.4.53; Nucleotide Metabolism - purine; Phosphodiesterase Q08499-6 5144 5q11.2-q12.1 human S126-p 458388 VHSQRREsFLYRSDS enzymatic activity, altered; enzymatic activity, induced 23826796; 31209056 10 21 1 +RETREG1 FAM134B Membrane protein, integral; Membrane protein, multi-pass Q9H6L5 54463 5p15.1 human K160-ac 1881577500 SWEVINSkPDERPRL molecular association, regulation; phosphorylation autophagy, induced FAM134B(INDUCES); CAMK2A(INDUCES) 37043189 1 1 0 +TIAM1 TIAM1 GEF; GEF, Rac/Rho; Motility/polarity/chemotaxis; Oncoprotein Q13009 7074 21q22.11 human S695-p 4727713 KRRSRFSsLWGLDTT protein stabilization; molecular association, regulation 14-3-3 beta(INDUCES) 25746002 1 5 23 +Irs1 IRS1 Adaptor/scaffold; Motility/polarity/chemotaxis P35570 25467 9q34 rat S731-p 2352500 TGDYMNMsPVGDSNT enzymatic activity, inhibited 8626671 2 0 0 The serine phosphorylation sites negatively regulate PI3 kinase activity associated with IRS-1. +Camk1 CAMK1A EC 2.7.11.17; KINASE; Kinase, protein; Protein kinase, CAMK; Protein kinase, Ser/Thr (non-receptor) Q91YS8 52163 6 E3|6 52.75 cM mouse T177-p 448527 DPGSVLStACGTPGY Pkinase autophagy, induced; cell growth, induced 35145192 10 6 7 induces mitophagy +FOXO1 FOXO1A DNA-binding; Nuclear receptor co-regulator; Oncoprotein; Transcription factor Q12778 2308 13q14.11 human S383-p 12607402 DNLNLLSsPTSLTVS intracellular localization transcription, altered 20061393 2 0 0 multiple site mutant (8A) +MDC1 MDC1 Cell cycle regulation Q14676 9656 6p21.33 human T331-p 477988 FGFIDSDtDAEEERI molecular association, regulation cell cycle regulation NBS1(INDUCES) 18678890 1 26 27 MDC1-NBS1 interaction regulates intra-S-phase checkpoint activation +NDC80 HEC1 Cell cycle regulation O14777 10403 18p11.32 human S44-p 474539 KPTFGKLsINKPTSE cell cycle regulation; cytoskeletal reorganization 17129782; 32027339; 35878017 9 4 0 +RPTOR Raptor Adaptor/scaffold Q8N122 57521 17q25.3 human S792-p 2314600 DKMRRASsYSSLNSL molecular association, regulation cell cycle regulation; carcinogenesis, inhibited; autophagy, induced; cell growth, inhibited; apoptosis, inhibited; transcription, altered; signaling pathway regulation 4E-BP1(DISRUPTS) 21460630; 21900751; 28778925; 34247189; 34604061; 34820368 36 4 0 +YAP1 YAP1 iso2 Oncoprotein; Transcription, coactivator/corepressor P46937-2 10413 11q22.1 human S94-p 3253276 RLRKLPDsFFKPPEP transcription, induced 19141641 8 3 3 +Prkch PKCH EC 2.7.11.13; KINASE; Kinase, protein; Protein kinase, AGC; Protein kinase, Ser/Thr (non-receptor) P23298 18755 12|12 C3 mouse S32-p 3074800 TRWSLRHsLFKKGHQ C2 molecular association, regulation; intracellular localization cell growth, inhibited CTLA-4(INDUCES) 24705298 2 3 8 +H3F3C H3 DNA-binding P84229 427887 chicken K9-ac 463820 RTKQTARkSTGGKAP Histone transcription, induced 19950192 230 26 341 +Prkcd PKCD EC 2.7.11.13; KINASE; Kinase, protein; Nuclear receptor co-regulator; Protein kinase, AGC; Protein kinase, Ser/Thr (non-receptor); Protein kinase, tyrosine (non-receptor); Tumor suppressor P28867 18753 14 B|14 18.82 cM mouse Y187-p 447579 WGLNKQGyKCRQCNA C1_1 molecular association, regulation; intracellular localization apoptosis, induced; transcription, altered Fyn(INDUCES) 10945993; 11739733 6 0 0 +KDM2A FBXL11 DEMETHYLASE; Demethylase; EC 1.14.11.27; Oxidoreductase Q9Y2K7 22992 11q13.2 human T632-p 482318 EVDQNEEtQDFEKKL PHD_4 molecular association, regulation DNA repair, induced DNA(DISRUPTS) 25823024 1 2 4 +ID3 ID3 DNA-binding; Transcription, coactivator/corepressor Q02535 3399 1p36.12 human S65-p 297110002 VPRGTQLsQVEILQR HLH molecular association, regulation DNA repair, induced MDC1(INDUCES) 29026069 1 0 0 +RBL1 Rb-like 1 Transcription, coactivator/corepressor; Tumor suppressor P28749 5933 20q11.23 human S615-p 36125980 HLPLMPMsPLMHPRV cell cycle regulation 34661528 1 5 0 +FOXM1 FOXM1 DNA-binding; Transcription factor Q08050 2305 12p13.33 human S739-p 18009877 SKILLDIsFPGLDED cell cycle regulation; transcription, induced 19160488 3 1 0 orderly mitotic progression +AQP2 AQP2 Channel, misc.; Membrane protein, integral; Membrane protein, multi-pass; Transporter; Transporter, aquaporin family P41181 359 12q13.12 human S256-p 449854 REVRRRQsVELHSPQ molecular association, regulation; intracellular localization exocytosis, induced HSP70(DISRUPTS); VTA1(DISRUPTS); TIRAP(INDUCES); AQP2(INDUCES) 11067864; 11076974; 12194985; 14519593; 15625084; 16120822; 16303856; 17940053; 18042467; 18664568; 19357255; 22778181; 24700872; 26714855; 28710278; 29145196; 32486031; 32529500 78 9 0 +MELK MELK EC 2.7.10.2; EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, CAMK; Protein kinase, Ser/Thr (non-receptor); Protein kinase, tyrosine (non-receptor); RNA splicing Q14680 9833 9p13.2 human S171-p 2861400 HLQTCCGsLAYAAPE Pkinase enzymatic activity, induced 16216881 2 0 0 +Arhgap31 CdGAP GAP; GAP, Rac/Rho A6X8Z5 12549 16|16 B4 mouse T776-p 456517 TPAPPPPtPLEEEPE activity, inhibited transcription, altered 16024771; 17158447; 20728428 3 0 0 increases CdGAP expression +KIF20A KIF20A Microtubule-binding; Motor O95235 10112 5q31.2 human S7-p 18011282 _MSQGILsPPAGLLS molecular association, regulation; intracellular localization; protein conformation cell cycle regulation INCENP(DISRUPTS) 24656812 1 4 0 favours solubility, inhibits microtubule binding +NCL NCL DNA-binding; Helicase; Nuclear receptor co-regulator; Nucleolus; RNA-binding P19338 4691 2q37.1 human S184-p 466006 AAAAAPAsEDEDDED intracellular localization cell cycle regulation; cell growth, induced 25313645 2 27 28 +TARDBP TDP-43 RNA-binding Q13148 23435 1p36.22 human K95-ub 15398515 TDASSAVkVKRAVQK protein degradation 32175624 1 7 6 +HIC1 HIC1 C2H2-type zinc finger protein; Transcription factor; Tumor suppressor Q14526 3090 17p13.3 human K333-ac 1910103 SLLYRWMkHEPGLGS molecular association, regulation transcription, induced; transcription, inhibited TAT(DISRUPTS); MTA1(DISRUPTS) 17283066; 20547755; 27725726 3 0 0 impaired-expression of the HIV-1 +KDM5A JARID1A DEMETHYLASE; Demethylase; EC 1.14.11.-; Nuclear receptor co-regulator; Nucleolus; Oxidoreductase; Transcription factor P29375 5927 12p13.33 human S1255-p 56630502 CLTERAMsWQDRARQ intracellular localization 27292631 1 0 0 JARID1A recruitment to the promoters of AKT-regulated genes +MAPT Tau iso8 ACETYLTRANSFERASE; Acetyltransferase; Cytoskeletal P10636-8 4137 17q21.31 human K174-ub 1873595600 NATRIPAkTPPAPKT protein degradation autophagy, induced 28972160 1 0 0 +GATA2 GATA2 Transcription factor P23769 2624 3q21.3 human S401-p 455583 QTRNRKMsNKSKKSK molecular association, regulation; intracellular localization; activity, inhibited cell growth, induced; cell differentiation, induced; transcription, induced; transcription, altered; cell growth, altered FOG1(INDUCES) 15837948; 35172146 2 0 5 +cdkn1a p21Cip1 Cell cycle regulation; Inhibitor Q683K8 dog S91-p 4943330 TCTLLPHsPERPEAS protein stabilization cell cycle regulation 22908227 2 0 0 +PROX1 PROX1 DNA-binding; Nuclear receptor co-regulator; Transcription factor Q92786 5629 1q32.3 human K353-sm 6124706 KHLAETLkQELNTAM molecular association, regulation; intracellular localization transcription, induced HDAC3(DISRUPTS) 18948102 1 0 0 Sumoylation downregulates the corepressor activity of Prox1 and reduces its recruitment of HDAC3. +Hnrnpf hnRNP F RNA splicing; RNA-binding; Spliceosome Q794E4 64200 4q42 rat K98-ub 15390280 TEMDWVLkHSGPNSA protein stabilization RNA splicing, induced 25959059 1 8 3 +TSC2 TSC2 Cell cycle regulation; GAP; GAP, misc.; Nuclear receptor co-regulator; Tumor suppressor P49815 7249 16p13.3 human S932-p 4728973 DDTPEKDsFRARSTS activity, inhibited signaling pathway regulation 30684133 1 2 5 mTORC1 activation and signaling +Creb1 CREB DNA-binding; Transcription factor Q01147 12912 1 C2|1 32.74 cM mouse K122-ac 459099 SRRPSYRkILNDLSS pKID activity, induced; molecular association, regulation transcription, induced SIRT1(INDUCES) 22078933; 26804914 4 0 0 Lys136 acetylation increases Creb sensitivity to PKA-dependent phosphorylation, K136Q mutant creb reverses the phenotype of WTD-fed SirBACO mice; enhanced by CBP, glucose sensing and regulate Hes-1 transcription +HSD3B2 HSD3B2 EC 1.1.1.145; EC 5.3.3.1; Endoplasmic reticulum; Isomerase; Lipid Metabolism - C21-steroid hormone; Lipid Metabolism - androgen and estrogen; Membrane protein, integral; Mitochondrial; Oxidoreductase P26439 3284 1p12 human S95-p 1410340101 FGVTHREsIMNVNVK 3Beta_HSD enzymatic activity, altered 30580688 1 1 0 Regulate steroidogenic enzyme activity +LOC100399755 GNRHR2 GPCR, family 1; Membrane protein, integral; Membrane protein, multi-pass; Receptor, GPCR Q95MG6 100399755 marmoset S339-p 454394 QELSMDSsREEGSRR receptor internalization, altered 15205374 1 0 0 +PKMYT1 Myt1 EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, Other; Protein kinase, Ser/Thr (non-receptor); Protein kinase, dual-specificity (non-receptor) Q99640 9088 16p13.3 human T461-p 11331002 STPRSRCtPRDALDL molecular association, regulation PIN1(INDUCES) 10504341 1 0 0 +Bmal1 BMAL1 DNA-binding; Transcription factor Q9WTL8 11865 7 F1|7 59.17 cM mouse K266-sm 3055600 KCNRPSVkVEDKDFA protein degradation transcription, induced 16109848 2 1 0 regulation of circadian clock +TRAF3 TRAF3 UBIQUITIN LIGASE; Ubiquitin conjugating system; Ubiquitin ligase Q13114 7187 14q32.32 human Y116-p 1869973805 EILALQIyCRNESRG ubiquitination 32779804 1 0 0 +ARHGEF7 ARHGEF7 iso1 GEF; GEF, Rac/Rho; Motility/polarity/chemotaxis Q14155-1 8874 13q34 human S516-p 455215 RKPERKPsDEEFASR RhoGEF67_u2 molecular association, regulation cytoskeletal reorganization KCC2(INDUCES) 26056138 4 54 30 increased increase number of dendritic spines and synapses +AKT3 Akt3 EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, AGC; Protein kinase, Ser/Thr (non-receptor) Q9Y243 10000 1q43-q44 human S472-p 447937 RPHFPQFsYSASGRE Pkinase_C phosphorylation carcinogenesis, induced; cell growth, induced; cell motility, altered 26523971; 36476861 10 9 20 induces TSC2 phosphorylation; neuronal development migration defects +Dab1 DAB1 iso2 Adaptor/scaffold P97318-2 13131 4 C6|4 47.79 cM mouse T470-p 479418 DISQLNLtPVTSTTP phosphorylation 16529723 1 0 0 inhibits tyrosine phosphorylation +Wasl N-WASP Adaptor/scaffold; Motility/polarity/chemotaxis O08816 682507 4q22 rat T259-p 23003804 IYDFIEKtGGVEAVK molecular association, regulation; protein conformation cytoskeletal reorganization 22250195 1 0 0 inhibits actin polymerization in vitro; inhibits the filopodia promoting activity of N-WASP +TRAF3 TRAF3 UBIQUITIN LIGASE; Ubiquitin conjugating system; Ubiquitin ligase Q13114 7187 14q32.32 human K436-ub 1877126905 KQEAVMGkTLSLYSQ molecular association, regulation; intracellular localization transcription, altered MAVS(INDUCES); TBK1(INDUCES) 32324863 1 1 0 TRIM24-mediated antiviral immunity, VSV-induced interaction of TRAF3 with MAVS and TBK1 +PHGDH PHGDH Amino Acid Metabolism - glycine, serine and threonine; Cell development/differentiation; EC 1.1.1.95; Oxidoreductase O43175 26227 1p12 human T78-p 4730715 QVVGRAGtGVDNVDL 2-Hacid_dh carcinogenesis, induced; cell growth, induced; apoptosis, inhibited 23374352 1 19 1 +TGFBR1 TGFBR1 EC 2.7.11.30; KINASE; Kinase, protein; Membrane protein, integral; Protein kinase, Ser/Thr (receptor); Protein kinase, TKL; Receptor, misc. P36897 7046 9q22.33 human K178-ub 38557705 ISEGTTLkDLIYDMT TGF_beta_GS intracellular localization cell cycle regulation; carcinogenesis, induced; transcription, induced 25622187 1 0 0 tumor cell invasion by inducing genes T?RI, Snail1, and matrix metallopeptidase 2 (MMP2) +RB1 Rb Nuclear receptor co-regulator; Oncoprotein; Transcription, coactivator/corepressor; Tumor suppressor P06400 5925 13q14.2 human T841-p 14160965 SIGESFGtSEKFQKI Rb_C molecular association, regulation cell cycle regulation; chromatin organization, altered; signaling pathway regulation E2F2(INDUCES); E2F1(INDUCES) DNA(DISRUPTS) 33219128 1 6 10 TCR signaling +STRAP STRAP Adaptor/scaffold; RNA splicing; UBIQUITIN LIGASE; Ubiquitin ligase Q9Y3F4 11171 12p12.3 human K147-ac 1876755700 SGHTSGIkKALWCSE WD40 protein stabilization transcription, induced 32527012 1 0 0 upregulation and stabilization of p53 as well as its targets +ELMO1 ELMO1 Cytoskeletal; Motility/polarity/chemotaxis Q92556 9844 7p14.2-p14.1 human Y18-p 455871 AIEWPGAyPKLMEID molecular association, regulation; intracellular localization NCK1(INDUCES); RHOG(INDUCES) 24928514 3 2 45 Nck1 enhances ELMO1 and RhoG interaction and promotes Rac1 activity; localization of ELMO1 to the plasma membrane +TAB1 TAB1 Activator; Motility/polarity/chemotaxis Q15750 10454 22q13.1 human S452-p 22869801 STNTHTQsSSSSSDG intracellular localization; phosphorylation; enzymatic activity, induced transcription, inhibited 22216226 1 0 0 TAB1 induce p38 MAPK phosphorylation and mRNA destabilization, induces p38 MAPK activation. TAB1 and p38MAPK mutually control eachother's phosphorylation status, activity and intracellular localization. +Slc12a3 NCCT Membrane protein, integral; Membrane protein, multi-pass; Transporter; Transporter, SLC family P55018 54300 19p13-p12 rat S71-p 469631 AYEHYANsALPGEPR AA_permease_N ubiquitination; receptor internalization, inhibited 24668812 15 2 1 ubiquitination reduced +KDM3A JMJD1A DEMETHYLASE; Demethylase; EC 1.14.11.-; Nuclear receptor co-regulator; Oxidoreductase Q9Y4C1 55818 2p11.2 human Y1101-p 462537 PDLGPKMyNAYGLIT methylation; enzymatic activity, induced carcinogenesis, induced; cell motility, induced; cell growth, induced; transcription, induced 30377265 1 1 1 induces H3 demethylation +Gpnmb GPNMB Membrane protein, integral Q99P91 93695 6 B2.3|6 23.82 cM mouse S546-p 12738565 TVKGKGLsVLLSHAK carcinogenesis, induced; cell motility, induced; cell growth, induced; transcription, altered 34327762 1 6 0 +AP2B1 AP2B1 Vesicle P63010 163 17q12 human Y737-p 450538 THRQGHIyMEMNFTN Alpha_adaptinC2 molecular association, regulation ARRB1(DISRUPTS); AGTRAP(DISRUPTS) 17456551 2 5 9 +CRTC2 TORC2 Transcription, coactivator/corepressor Q53ET0 200186 1q21.3 human S238-p 1870757301 DAKKLSSsSSRPRSC TORC_M molecular association, regulation; intracellular localization; phosphorylation carcinogenesis, induced; cell motility, induced; cell growth, induced; transcription, induced CREB(INDUCES) 33000695 1 0 0 inhibits phosphorylation at S171 +MAP2K1 MEK1 EC 2.7.12.2; KINASE; Kinase, protein; Protein kinase, STE; Protein kinase, dual-specificity (non-receptor) Q02750 5604 15q22.31 human T292-p 448287 ETPPRPRtPGRPLSS Pkinase molecular association, regulation; enzymatic activity, inhibited; phosphorylation carcinogenesis, induced; transcription, induced; signaling pathway regulation ERK2(INDUCES); ERK1(DISRUPTS); RAF1(INDUCES) 10567369; 14993270; 25971971; 33789117; 8114697; 9351825 14 6 0 induces ERK pathway; inhibits ERK mediated phosphorylation at T286 and ERK phosphorylation, regulates Ras/MEK/ERK signaling +Raet1e RAET1E Membrane protein, integral Q9CZQ6 379043 10|10 A3 mouse K80-ac 1877559401 MTSGDPGkMANATGK MHC_I_2 protein stabilization 33279621 1 0 0 protects RAET1E from shedding; induces antitumor immunity +SRC Src EC 2.7.10.2; KINASE; Kinase, protein; Oncoprotein; Protein kinase, TK; Protein kinase, tyrosine (non-receptor) P12931 6714 20q11.23 human K298-ub 1877830400 GTTRVAIkTLKPGTM ubiquitination; enzymatic activity, induced 31619538 2 0 0 +LPIN1 LPIN1 EC 3.1.3.4; Phosphatase, lipid Q14693 23175 2p25.1 human Y413-p 1871177711 DPEVAALyFPKNGDP enzymatic activity, induced carcinogenesis, induced; cell growth, induced 33203880 1 1 0 Activity of PAP, increase glycolipid synthesis +TTK TTK Cancer Testis Antigen (CTA); EC 2.7.12.1; KINASE; Kinase, protein; Protein kinase, Other; Protein kinase, dual-specificity (non-receptor) P33981 7272 6q14.1 human S291-p 31862439 CDVKTDDsVVPCFMK intracellular localization; enzymatic activity, induced 26119734 1 1 0 regulates spindle assembly checkpoint and recruitment of SAC proteins +BRD4 BRD4 KINASE; Kinase, protein; Protein kinase, Ser/Thr (non-receptor); Protein kinase, atypical O60885 23476 19p13.12 human Y98-p 1874101904 KLNLPDYyKIIKTPM Bromodomain protein stabilization; molecular association, regulation; ubiquitination carcinogenesis, induced; chromatin organization, altered; transcription, induced BET1(DISRUPTS); STAT3(INDUCES); UCHL3(INDUCES) DNA(INDUCES) 34290255 1 1 0 inhibits ubiquitination +FOSL1 FRA1 DNA-binding; Transcription factor P15407 8061 11q13.1 human S265-p 478352 PSSDPLGsPTLLAL_ molecular association, regulation; protein stabilization carcinogenesis, induced; cell motility, induced; cell growth, induced; cytoskeletal reorganization AXL(INDUCES) 17371847; 21822309; 22286759 3 8 6 +CLASP2 CLASP2 Cytoskeletal; Motility/polarity/chemotaxis O75122 23122 3p22.3 human S537-p 22648007 REASRESsRDTSPVR molecular association, regulation; intracellular localization cytoskeletal reorganization EB1(DISRUPTS); IQGAP1(DISRUPTS) 19638411 1 3 0 inhibits binding with microtubules +Mknk2 Mnk2 EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, CAMK; Protein kinase, Ser/Thr (non-receptor); Translation Q8CDB0 17347 10|10 C1 mouse S434-p 456331 CLQLSPPsQSKLAQR molecular association, regulation ERK1(INDUCES) 16162500 1 3 2 +STAT5B STAT5B DNA-binding; Oncoprotein; Transcription factor P51692 6777 17q21.2 human S731-p 448751 TYMDQAPsPAVCPQA activity, induced; enzymatic activity, induced transcription, altered 17822672; 25006129 14 0 0 increases the basal transcriptional activity of the Y740/743 mutant comparing with the wt STAT5B +Rps6 S6 Translation P62754 20104 4|4 C4 mouse S235-p 448092 IAKRRRLsSLRASTS carcinogenesis, induced; carcinogenesis, inhibited; signaling pathway regulation; neural plasticity; cell growth, induced; autophagy, inhibited; translation, induced; transcription, inhibited 18851840; 23361300; 33826903; 34342159; 34426542; 34695513; 35428325; 37068088 246 60 972 Promotes axonal regeneration in the nervous systems +MAP3K7 TAK1 EC 2.7.11.25; KINASE; Kinase, protein; Protein kinase, Ser/Thr (non-receptor); Protein kinase, TKL O43318 6885 6q15 human S192-p 448289 HMTNNKGsAAWMAPE PK_Tyr_Ser-Thr phosphorylation; enzymatic activity, induced 15590691; 20538596 5 1 0 +Wnk4 WNK4 EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, Other; Protein kinase, Ser/Thr (non-receptor) Q80UE6 69847 11|11 D mouse K662-ub 40323302 QMRKNPVkTLRRRPR protein degradation 23576762 1 1 0 regulates electrolyte homeostasis and involved in Pseudohypoaldosteronism type II (PHAII) pathogenesis +Eps8 EPS8 Adaptor/scaffold Q08509 13860 6 G1|6 66.78 cM mouse T317-p 3801518 GPGEGVLtLRAKPPP cytoskeletal reorganization 25456499 1 18 12 spine development +ESR1 ER-alpha DNA-binding; Nuclear receptor; Transcription factor P03372 2099 6q25.1-q25.2 human K171-sm 27992517 RLASTNDkGSMAMES Oest_recep transcription, inhibited 22826433 1 1 0 ER-alpha SUMOylation suppresses ER transcriptional activation by full antiestrogens (AEs) in the absence of induced ER degradation +ERBB4 HER4 EC 2.7.10.1; KINASE; Kinase, protein; Membrane protein, integral; Protein kinase, TK; Protein kinase, tyrosine (receptor) Q15303 2066 2q34 human Y1221-p 4825108 NTLGKAEyLKNNILS molecular association, regulation GRB2(INDUCES) 16729043 1 1 0 +Ppp2r5b PPP2R5B Motility/polarity/chemotaxis; Protein phosphatase, regulatory subunit Q6PD28 225849 19|19 A mouse S44-p 10405463 RRARPRRsHSSSQFR molecular association, regulation; phosphorylation PPP2CA(INDUCES); PPP2R5B(INDUCES) 21329884 1 3 7 PPP2R2R5B phosphorylation by CLK2 is required for the PPP2CA-AKT complex; induces AKT dephosphorylation +Gata3 GATA3 Transcription factor P23772 14462 2 A1|2 6.69 cM mouse T155-p 33638003 HLFTFPPtPPKDVSP protein degradation 24820417 1 0 0 phosphorylated during G2/M phase +RRM2 RRM2 EC 1.17.4.1; Nucleotide Metabolism - purine; Nucleotide Metabolism - pyrimidine; Other Amino Acids Metabolism - glutathione; Oxidoreductase P31350 6241 2p25.1 human T33-p 3189775 SLVDKENtPPALSGT protein degradation; molecular association, regulation; ubiquitination; intracellular localization cell cycle regulation; DNA repair, inhibited CCNF(INDUCES) 22632967; 26602815 2 27 30 +FOXO3 FOXO3A Autophagy; DNA-binding; Oncoprotein; Transcription factor O43524 2309 6q21 human S315-p 449109 DFRSRTNsNASTVSG intracellular localization; activity, inhibited cell cycle regulation; apoptosis, inhibited; transcription, inhibited 11154281; 26376801 5 0 1 +Rbm20 RBM20 E9PT37 309544 1q55 rat S638-p 31086436 YGPERPRsRSPMSRS intracellular localization RNA splicing, altered; transcription, altered RNA(INDUCES) 35394688; 36140694 2 3 0 +Elk1 ELK1 DNA-binding; Transcription factor A4GTP4 314436 Xq11 rat S382-p 447872 IHFWSTLsPIAPRSP transcription, induced 21677150 45 1 0 +Mecp2 MECP2 Transcription, coactivator/corepressor Q00566 29386 Xq37 rat S292-p 25696402 KKAVKESsIRSVQET intracellular localization 25511996 1 1 0 localization of phosphorylated form from nucleus to cytoplasm. +DYRK2 DYRK2 iso2 EC 2.7.12.1; KINASE; Kinase, protein; Protein kinase, CMGC; Protein kinase, dual-specificity (non-receptor) Q92630-2 8445 12q15 human T32-p 1874397806 SNKRTVLtTQPNGLT intracellular localization; enzymatic activity, inhibited cell cycle regulation; apoptosis, induced 34363019 1 1 0 +VCP VCP Chaperone; DNA repair, damage; EC 3.6.4.6; Endoplasmic reticulum; Hydrolase P55072 7415 9p13.3 human S352-p 457556 AATNRPNsIDPALRR AAA apoptosis, inhibited 16551632 2 6 0 +FUS hnRNP P2 DNA-binding; Nuclear receptor co-regulator; Oncoprotein; RNA splicing; RNA-binding; SUMO LIGASE P35637 2521 16p11.2 human R524-me 1873375604 HRQDRRErPY_____ intracellular localization KPNB2(DISRUPTS) 22968170 1 0 0 Arginines in the RGG3 domain are required for nuclear import of mutant hnRNP, and arginine methylation in this domain reduces KPNB2 binding. +FGF14 FGF14 Cell development/differentiation; Cytokine Q92915 2259 13q33.1 human S228-p 54201601 PGVTPSKsTSASAIM activity, induced; intracellular localization SCN2A(INDUCES); SCN8A(INDUCES) 26917740 1 1 0 axodendritic polarity, FGF14 modulation of Nav mediated currents +BECN1 beclin 1 Adaptor/scaffold; Autophagy; Membrane protein, peripheral Q14457 8678 17q21.31 human Y229-p 28850302 LDQEEAQyQREYSEF APG6_N molecular association, regulation cell differentiation, inhibited; carcinogenesis, induced; autophagy, inhibited Bcl-2(INDUCES); beclin 1(INDUCES); rubicon(INDUCES); PIK3C3(DISRUPTS) 24034250; 29610308 2 0 0 kinase active HER2 +RASAL2 RASAL2 iso2 GAP; GAP, Ras Q9UJF2-2 9462 1q25.2 human S351-p 1872043503 TLFARTTsKTKADNI C2 molecular association, regulation carcinogenesis, induced; autophagy, induced beclin 1(INDUCES); PIK3C3(INDUCES); ATG14(INDUCES) 33563064 1 1 0 binding to PIK3C3 induces PIK3C3 bindidng to PtdIns +FOXO1 FOXO1A DNA-binding; Nuclear receptor co-regulator; Oncoprotein; Transcription factor Q12778 2308 13q14.11 human K265-ac 459033 DNNSKFAkSRSRAAK molecular association, regulation; intracellular localization; activity, inhibited; phosphorylation carcinogenesis, inhibited; apoptosis, induced; transcription, inhibited DNA(DISRUPTS) 15220471; 16076959; 18786403; 20519497; 27132507 9 1 0 +EHMT2 EHMT2 Amino Acid Metabolism - lysine degradation; EC 2.1.1.43; METHYLTRANSFERASE; Methyltransferase; Methyltransferase, protein lysine Q96KQ7 10919 6p21.33 human K1008-sm 1878097304 RLLQEFNkIEPPLIF molecular association, regulation; intracellular localization cell cycle regulation; cell growth, induced; transcription, induced PCAF(INDUCES) 30867409 1 0 0 SUMOylated G9a is recruited to E2F1 target gene promoters, EHMT2 is an activator of proliferation and E2F1-target gene expression +Nfe2l2 NRF2 DNA-binding; Transcription factor Q60795 18024 2 C3|2 44.75 cM mouse S347-p 18258502 NTSPSRAsPEHSVES protein degradation; molecular association, regulation BTRC(INDUCES) 21245377 3 1 0 +DDX3X DDX3 Cell cycle regulation; EC 3.6.4.13; Helicase; RNA-binding; Spliceosome; Translation initiation O00571 1654 Xp11.4 human T323-p 457784 GCHLLVAtPGRLVDM DEAD enzymatic activity, inhibited translation, altered; cell growth, altered 16280325; 17379183 2 12 1 +DCK DCK EC 2.7.1.74; Kinase, other; Nucleotide Metabolism - purine; Nucleotide Metabolism - pyrimidine P27707 1633 4q13.3 human T3-p 460584 _____MAtPPKRSCP protein stabilization; phosphorylation 20544527 3 6 0 +NFKB1 NFkB-p105 DNA-binding; Transcription factor P19838 4790 4q24 human K431-ac 465125 TKSNAGMkHGTMDTE molecular association, regulation; intracellular localization DNA(INDUCES) 11739381 1 1 1 nuclear translocation +CTDSPL2 CTDSPL2 EC 3.1.3.-; Motility/polarity/chemotaxis; PHOSPHATASE; Phosphatase Q05D32 51496 15q15.3-q21.1 human S134-p 4272262 EDNPSSGsPPRTTLL cell cycle regulation; carcinogenesis, induced; cell motility, induced; cell growth, induced; transcription, inhibited 34813892 1 9 0 +TP53 p53 Activator; DNA-binding; Motility/polarity/chemotaxis; Nuclear receptor co-regulator; Transcription factor; Tumor suppressor P04637 7157 17p13.1 human K386-ub 464662 RHKKLMFkTEGPDSD protein degradation; molecular association, regulation; intracellular localization transcription, induced; transcription, inhibited ING1(DISRUPTS) 10562557; 11046142; 17371868; 19927155; 21731648; 31002112 10 0 1 K370/372/373/381/382/386/R mutant shows 613-fold activation of p53; binds unmodified or six multimonoubiquitinated forms of wild-type p53; stimulates the transcriptional activity of p53; translocation of p53 from the nucleus to the cytoplasm, promotes EMT in EOC cells +UBTF UBF DNA-binding; Nucleolus; Transcription factor P17480 7343 17q21.31 human K232-m3 31094522 EVKDSLGkQWSQLSD HMG_box molecular association, regulation chromatin organization, altered; transcription, inhibited 24234436 1 1 0 +SLC6A3 DAT Membrane protein, integral; Membrane protein, multi-pass; Transporter; Transporter, SLC family Q01959 6531 5p15.33 human T62-p 451139 VEAQDREtWGKKIDF SNF protein conformation 19098122 2 0 0 +CREB1 CREB DNA-binding; Transcription factor P16220 1385 2q33.3 human K271-sm 12063903 PAEEAARkREVRLMK bZIP_1 protein stabilization transcription, induced 12552083 2 0 0 +GRK2 GRK2 EC 2.7.11.15; KINASE; Kinase, protein; Protein kinase, AGC; Protein kinase, Ser/Thr (non-receptor) P25098 156 11q13.2 human K30-ub 1872283503 TPAARASkKILLPEP protein degradation 17006543 1 0 0 +C3AR1 C3aR GPCR, family 1; Membrane protein, integral; Membrane protein, multi-pass; Receptor, GPCR Q16581 719 12p13.31 human T466-p 27145809 SEELTRStHCPSNNV receptor desensitization, induced; molecular association, regulation transcription, inhibited ARRB2(INDUCES) 23077507 1 0 0 +NPAT NPAT Cell cycle regulation; Transcription regulation Q14207 4863 11q22.3 human S779-p 2286402 ILSSPTKsPTKNAEL NPAT_C transcription, induced 10995387 1 2 0 multiple sites deletion mutant +HNRNPA1 hnRNP A1 Nuclear export; RNA splicing; RNA-binding; Spliceosome P09651 3178 12q13.13 human R225-m2 476707 RGGNFSGrGGFGGSR molecular association, regulation Ebp1(INDUCES); CCND1(INDUCES) 31473880 2 6 21 +NRGN neurogranin Cell development/differentiation Q92686 4900 11q24.2 human S36-p 455913 AAAKIQAsFRGHMAR IQ phosphorylation 17505539; 25303525 6 5 0 CREB phosphorylation; inhibits ERK phosphorylation +Mapt Tau ACETYLTRANSFERASE; Acetyltransferase; Cytoskeletal P10637 17762 11 67.79 cM|11 E1 mouse S506-p 447929 GSRSRTPsLPTPPTR molecular association, regulation AKAP5(INDUCES); PKAR2B(INDUCES); PKACB(INDUCES) 10460255 63 24 42 +COPS5 COPS5 Adaptor/scaffold; DEUBIQUITINASE; EC 3.4.-.-; Nuclear receptor co-regulator; Protease; Transcription, coactivator/corepressor; Translation Q92905 10987 8q13.1 human S177-p 1874115102 IDPTRTIsAGKVNLG carcinogenesis, induced; cell motility, induced; cell growth, induced; transcription, induced 34244488 1 1 0 +PTH1R PTHR GPCR, family 2; Membrane protein, integral; Membrane protein, multi-pass; Receptor, GPCR Q03431 5745 3p21.31 human K484-ub 15496531 WTLALDFkRKARSGS ubiquitination 29444827 1 1 1 abrogation of phosphorylation at positions T387and T392 dramatically decreased PTHR ubiquitination +Dlg4 PSD-95 Adaptor/scaffold P31016 29495 10q24 rat Y523-p 4093600 REDSVLSyETVTQME activity, induced 18721130 3 0 0 +SOS1 SOS1 Adaptor/scaffold; GEF; GEF, Ras; Motility/polarity/chemotaxis Q07889 6654 2p22.1 human S1161-p 9413177 PPRRRPEsAPAESSP molecular association, regulation signaling pathway regulation 14-3-3 epsilon(INDUCES) 22827337 1 5 16 +Cers2 LASS2 DNA-binding; Membrane protein, integral; Membrane protein, multi-pass; Transferase Q924Z4 76893 3|3 F2.1 mouse S349-p 469771 DREETESsEGEETAA enzymatic activity, induced 26887952 1 43 198 +IRAK1 IRAK1 EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, Ser/Thr (non-receptor); Protein kinase, TKL P51617 3654 Xq28 human T209-p 450949 LCEISRGtHNFSEEL molecular association, regulation; protein conformation; phosphorylation; enzymatic activity, induced signaling pathway regulation TRAF6(INDUCES) 14625308; 31511642 5 1 0 induces MAPK and NF-kB signaling pathways by inducing phosphorylation of JNK and ERK +SREBF1 SREBP-1 DNA-binding; Membrane protein, integral; Membrane protein, multi-pass; Transcription factor P36956 6720 17p11.2 human T59-p 900975702 AGSGAGGtDPASPDT protein stabilization cell growth, induced; transcription, induced PKM(INDUCES) 29514980 1 0 0 PKM2 interaction with nuclear SREBP-1a increases SREBP-target gene expression and subsequent lipid biosynthesis in cancer cells. +Mapk7 ERK5 EC 2.7.11.24; KINASE; Kinase, protein; Protein kinase, CMGC; Protein kinase, Ser/Thr (non-receptor) Q9WVS8 23939 11|11 B2 mouse K22-sm 2887212 GEPPGRVkAEPVHTA molecular association, regulation apoptosis, induced; transcription, inhibited; signaling pathway regulation SRC-1(DISRUPTS) 18218985; 18467627 4 0 0 +PCBP1 hnRNP E1 RNA splicing; RNA-binding; Translation Q15365 5093 2p13.3 human T60-p 478358 NCPERIItLTGPTNA KH_1 molecular association, regulation; intracellular localization RNA splicing, induced; transcription, induced; translation, induced; signaling pathway regulation DNA(INDUCES); RNA(DISRUPTS) 17389360 1 0 0 PKA-hnRNPE1 pathway +BRF1 GTF3B Transcription initiation complex Q92994 2972 14q32.33 human S450-p 3208533 GDGELDLsGIDDLEI BRF1 molecular association, regulation cell cycle regulation; transcription, induced GTF3C1(INDUCES) RNA(INDUCES) 22281053 1 6 0 induce POLIII transcription; binds to tRNA and 5SrRNA genes +Glp1r GLP1R GPCR, family 2; Membrane protein, integral; Membrane protein, multi-pass; Receptor, GPCR P32301 25051 20p12 rat S416-p 1867747800 VQMEFRKsWERWRLE molecular association, regulation; intracellular localization cell growth, induced KPNA2(DISRUPTS) 32010959 1 0 0 +BRSK2 BRSK2 EC 2.7.11.1; EC 2.7.11.26; KINASE; Kinase, protein; Protein kinase, CAMK; Protein kinase, Ser/Thr (non-receptor) Q8IWQ3 9024 11p15.5 human T174-p 456031 VGDSLLEtSCGSPHY Pkinase cytoskeletal reorganization 34936879 5 1 1 +Ido1 INDO Amino Acid Metabolism - tryptophan; Cell cycle regulation; EC 1.13.11.52; Oxidoreductase P28776 15930 8|8 A2 mouse Y115-p 21393600 PRNIAVPyCELSEKL IDO molecular association, regulation transcription, induced; signaling pathway regulation SHP-2(INDUCES); SHP-1(INDUCES) 21804557 1 0 0 Phosphorylation of INDO at Y115 and Y253 induced enzyme activity of SHP-1/SHP-2. +IGF2BP2 IGF2BP2 RNA-binding; Translation Q9Y6M1 10644 3q27.2 human K509-sm 1881342900 FNPKEEVkLEAHIRV protein stabilization cell growth, induced 34345216 1 0 0 promotes vasculogenic mimicry (VM) formation in glioma cells +H2BC3 H2B DNA-binding P33778 3018 6p22.2 human K20-ac 465512 GSKKAITkAQKKDGK Histone transcription, altered 16283522; 17560255 6 10 232 +CD6 CD6 Cell surface; Membrane protein, integral P30203 923 11q12.2 human S567-p 28095007 SNSESSTsSGEDYCN phosphorylation signaling pathway regulation 23711376 1 0 0 ERK1/2 phosphorylation, MAPK pathway activation +DNMT1 DNMT1 Amino Acid Metabolism - cysteine and methionine; Cell development/differentiation; EC 2.1.1.37; METHYLTRANSFERASE; Methyltransferase; Methyltransferase, DNA; Transcription regulation P26358 1786 19p13.2 human K891-ac 25171010 PTEDNKFkFCVSCAR cell cycle regulation 21947282 1 1 0 +Esrrg ERR3 DNA-binding; Nuclear receptor; Transcription factor P62509 26381 1|1 H5-H6 mouse K40-sm 6048402 SSCSSFIkTEPSSPA transcription, inhibited 18063693 2 0 0 +Cryaa CRYA1 Chaperone; Heat shock protein P24623 24273 20p12 rat S145-p 452106 HRRYRLPsNVDQSAL HSP20 apoptosis, inhibited 22414529 2 6 1 cytoprotective effect +IKBKG IKKG Adaptor/scaffold; Protein kinase, regulatory subunit Q9Y6K9 8517 Xq28 human S43-p 449037 PAMLHLPsEQGAPET sumoylation; molecular association, regulation; ubiquitination; intracellular localization transcription, induced; signaling pathway regulation IKKB(INDUCES) 31932854 4 2 0 induces NF-KB pathway and induces NF-KB activation/transcription +RHOA RHOA G protein; G protein, monomeric; G protein, monomeric, Rho; Motility/polarity/chemotaxis; Oncoprotein P61586 387 3p21.31 human Y42-p 150180312 VPTVFENyVADIEVD Ras protein degradation; molecular association, regulation; ubiquitination; intracellular localization carcinogenesis, inhibited; cell motility, induced; cell growth, induced; transcription, induced; signaling pathway regulation ROCK1(INDUCES); VAV2(INDUCES); RhoGDI alpha(DISRUPTS); CTNNB1(INDUCES); ROCK1(DISRUPTS); ROCK2(INDUCES); IKKG(INDUCES) 28712859; 31056743; 31973815; 33388549 7 0 0 induces superoxide production pathway; super oxide production +NELFE RDBP Mitochondrial; Transcription, coactivator/corepressor P18615 7936 6p21.33 human S49-p 3181405 SQGGVKRsLSEQPVM molecular association, regulation transcription, induced 14-3-3 epsilon(INDUCES) 29523821 1 23 2 dissociation of the NELF complex from chromatin, which is accompanied by RNA polymerase II elongation +MAP4 MAP4 Cytoskeletal; Motility/polarity/chemotaxis P27816 4134 3p21.31 human T521-p 452281 MALGKDVtPPPETEV protein degradation; molecular association, regulation carcinogenesis, inhibited; cell growth, inhibited FBXW7(INDUCES) 36991467 1 61 43 +MAPT Tau iso8 ACETYLTRANSFERASE; Acetyltransferase; Cytoskeletal P10636-8 4137 17q21.31 human S289-p 487456 LDLSNVQsKCGSKDN Tubulin-binding molecular association, regulation; protein conformation Tau iso8(INDUCES); Tau(INDUCES) 21204788; 36003083; 36786552 6 3 0 +Kcnb1 Kv2.1 Channel, cation; Channel, ligand-gated; Channel, potassium; Membrane protein, integral; Membrane protein, multi-pass P15387 25736 3q42 rat S444-p 4714867 ERAKRNGsIVSMNMK activity, induced 22006306 1 5 0 +ADRB2 ADRB2 GPCR, family 1; Membrane protein, integral; Membrane protein, multi-pass; Receptor, GPCR P07550 154 5q32 human Y141-p 449832 AITSPFKyQSLLTKN 7tm_1 activity, induced 8521811 4 0 0 +Cacng2 Stargazin Channel, calcium; Membrane protein, integral; Membrane protein, multi-pass Q71RJ2 84347 7q34 rat S241-p 455317 QRRSRSSsRSTEPSH molecular association, regulation neural plasticity PSD-95(INDUCES) 25843401 3 0 0 +CDK2AP1 CDK2AP1 Cell cycle regulation; DNA replication; Tumor suppressor O14519 8099 12q24.31 human S46-p 25126700 LSDYGPPsLGYTQGT CDK2AP molecular association, regulation; protein conformation 22427660 1 1 0 +PITPNC1 PITPNC1 Lipid-binding Q9UKF7 26207 17q24.2 human S274-p 454503 SVRSAPSsAPSTPLS activity, induced; protein stabilization; molecular association, regulation 14-3-3 beta(INDUCES); 14-3-3 epsilon(INDUCES) 21728994; 26977884 2 5 3 +Vasp VASP Cytoskeletal; Motility/polarity/chemotaxis P70460 22323 7|7 A3 mouse S317-p 469024 TTLPRMKsSSSVTTS molecular association, regulation cell adhesion, induced 21945940 3 15 45 increased actin filament binding in vitro, increased aggregation of cells, increased VASP at cell-cell adhesions +Ces1d CES1D iso2 EC 3.1.1.1; EC 3.1.1.67 NP_579829 113902 19p11 rat S506-p 3540200 ANFARNGsPNGGGLP COesterase enzymatic activity, induced 15866484 2 0 0 increases cholesterol esterase activities and decreases PNPA esterase (change of substrate specificity from water soluble to hydrophobic substrates) +NR3C2 MCR DNA-binding; Nuclear receptor P08235 4306 4q31.23 human S227-p 25692900 FGSFPVHsPITQGTP protein degradation; ubiquitination transcription, inhibited 22798426 1 0 0 +POU3F2 Oct7 DNA-binding; Motility/polarity/chemotaxis; Transcription factor P20265 5454 6q16.1 human T440-p 4928201 PPHHGVQtPVQ____ DNA repair, altered; signaling pathway regulation DNA(INDUCES) 30804224 1 0 4 +KHDRBS1 KHDRBS1 RNA-binding Q07666 10657 1p35.2 human T33-p 7990374 AHPSVRQtPSRQPPL molecular association, regulation; intracellular localization; protein conformation cell cycle regulation; RNA splicing, inhibited; cell growth, induced; apoptosis, inhibited RNA(DISRUPTS) 36537190 1 10 3 +ABL1 Abl EC 2.7.10.2; KINASE; Kinase, protein; Oncoprotein; Protein kinase, TK; Protein kinase, tyrosine (non-receptor) P00519 25 9q34.12 human S619-p 1779805 PTPPKRSsSFREMDG molecular association, regulation; phosphorylation; enzymatic activity, induced Abi-2(DISRUPTS) 18161990 1 0 0 interaction in vitro and in vivo; phosphorylation of this site enhances the association and phosphorylation of the Abl substrate, Crk. +Junb JunB Motility/polarity/chemotaxis; Oncoprotein; Transcription factor P09450 16477 8 C3|8 41.41 cM mouse K301-sm 3144821 EDKVKTLkAENAGLS bZIP_1 intracellular localization transcription, induced 18424718 1 1 0 +Kcnj16 Kir5.1 Membrane protein, integral; Membrane protein, multi-pass P52191 29719 10q32.1 rat S417-p 451508 LNRISMEsQM_____ molecular association, regulation; intracellular localization; activity, inhibited PSD-95(DISRUPTS) 11988170 1 0 0 +APAF1 APAF Apoptosis O14727 317 12q23.1 human K224-ub 21129052 PLNIEEAkDRLRILM NB-ARC molecular association, regulation; ubiquitination SQSTM1(INDUCES) 31329620 1 3 0 binds and forms aggregates in the cytosol, activates caspase-9 in cells that stably express bcl-xl +Pnpla2 PNPLA2 EC 3.1.1.3; Lipase; Membrane protein, integral Q8BJ56 66853 7|7 F5 mouse S406-p 473045 VELRRAQsLPSVPLS molecular association, regulation; enzymatic activity, induced 14-3-3 beta(INDUCES) 21641555; 34352257 8 29 54 +HAS2 HAS2 EC 2.4.1.212; Membrane protein, integral; Membrane protein, multi-pass; Motility/polarity/chemotaxis; Transferase Q92819 3037 8q24.13 human K190-ub 14991106 IMQKWGGkREVMYTA enzymatic activity, induced 20507985 2 1 0 +GTF2I GTF2I iso2 DNA-binding; Transcription, coactivator/corepressor P78347-2 2969 7q11.23 human S633-p 452350 QSPKRPRsPGSNSKV transcription, altered 10648599 1 19 33 +TFAP2A AP-2 alpha DNA-binding; Transcription factor P05549 7020 6p24.3 human S258-p 5024712 GVLRRAKsKNGGRSL TF_AP-2 molecular association, regulation transcription, altered DNA(INDUCES) 18845787 2 0 0 +KLF8 KLF8 C2H2-type zinc finger protein; DNA-binding; Transcription factor O95600 11279 Xp11.21 human K67-sm 3726909 PALFNDIkIEPPEEL cell cycle regulation; transcription, altered 16617055 2 0 0 +XRCC1 XRCC1 DNA repair, damage P18887 7515 19q13.31 human Y515-p 40274401 EENGEDPyAGSTDEN molecular association, regulation PARP1(DISRUPTS) 25477519 1 1 0 +Creb1 CREB iso1 DNA-binding; Transcription factor P15337-1 81646 9q32 rat S133-p 448228 EILSRRPsYRKILND pKID activity, induced; molecular association, regulation; intracellular localization; protein conformation neural plasticity; cell growth, induced; transcription, induced; signaling pathway regulation; transcription, altered; cell growth, altered CREM iso2(INDUCES); CBP(INDUCES) DNA(INDUCES) 10722651; 10804193; 11013247; 11094091; 11123304; 11278709; 11701463; 11731096; 11796524; 11970864; 12114502; 12162494; 12163549; 14597636; 15522277; 17337597; 18378685; 19943942; 21949366; 28716938; 32111982; 34635097; 35053838; 35260079; 7958915; 8688081; 8887554; 9413984; 9687510; 9829964 311 5 61 +Oprm1 MOR-1 GPCR, family 1; Membrane protein, integral; Membrane protein, multi-pass; Receptor, GPCR P33535 25601 1q11 rat T357-p 3063303 FCIPTSStIEQQNST receptor desensitization, altered; phosphorylation 12123746 1 1 0 +HIPK2 HIPK2 EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, CMGC; Protein kinase, Ser/Thr (non-receptor) Q9H2X6 28996 7q34 human Y361-p 449571 SKAVCSTyLQSRYYR Pkinase protein stabilization; molecular association, regulation; intracellular localization; protein conformation; phosphorylation cell cycle regulation; apoptosis, induced; cell growth, inhibited; signaling pathway regulation; transcription, inhibited SIAH2(INDUCES); PIN1(INDUCES) 23000554; 24196445; 31387937; 31519758 6 78 3324 +SCN1A SCN1A Channel, sodium; Membrane protein, integral; Membrane protein, multi-pass P35498 6323 2q24.3 human S1918-p 36276481 KRKQEEVsAVIIQRA molecular association, regulation Calmodulin(INDUCES) 30142967 1 1 0 +SUV39H1 SUV39H1 Amino Acid Metabolism - lysine degradation; EC 2.1.1.43; METHYLTRANSFERASE; Methyltransferase; Methyltransferase, protein lysine O43463 6839 Xp11.23 human Y303-p 1871199001 TYLFDLDyVEDVYTV SET methylation; enzymatic activity, induced signaling pathway regulation 30833073 1 0 0 NRG-1/ErbB4 signaling +Crem CREM DNA-binding; Transcription factor P27699 12916 18|18 A1 mouse S290-p 450066 ASPGSLHsPQQLAEE activity, inhibited transcription, altered 8114763 4 12 1 +PRKD1 PRKD1 Autophagy; EC 2.7.11.13; KINASE; Kinase, protein; Motility/polarity/chemotaxis; Protein kinase, CAMK; Protein kinase, Ser/Thr (non-receptor) Q15139 5587 14q12 human S910-p 447632 KALGERVsIL_____ enzymatic activity, inhibited; phosphorylation; enzymatic activity, induced signaling pathway regulation 16563698; 19029298; 21285358; 34767572 43 13 0 autophosphorylation of this site activates NLRP3; NLRP3 inhibition prevents phosphorylation of this site +Hnrnpf hnRNP F RNA splicing; RNA-binding; Spliceosome Q794E4 64200 4q42 rat K224-ub 486692 RRYIGIVkQAGLDRM protein stabilization RNA splicing, induced 25959059 1 9 73 +SLC5A5 SLC5A5 Membrane protein, integral; Membrane protein, multi-pass; Transporter; Transporter, SLC family Q92911 6528 19p13.11 human S43-p 990307 LARGGQRsAEDFFTG activity, induced 17913707 1 1 1 +PAG1 PAG Adaptor/scaffold; Membrane protein, integral Q9NWQ8 55824 8q21.13 human Y299-p 1806902 KRFSSLSyKSREEDP PAG molecular association, regulation LYN(INDUCES) 18070987 1 0 0 +CDK7 CDK7 Cell cycle regulation; EC 2.7.11.22; EC 2.7.11.23; KINASE; Kinase, protein; Nuclear receptor co-regulator; Protein kinase, CMGC; Protein kinase, Ser/Thr (non-receptor) P50613 1022 5q13.2 human S164-p 450041 GLAKSFGsPNRAYTH Pkinase molecular association, regulation; protein conformation; enzymatic activity, induced cell cycle regulation; cell growth, induced; cytoskeletal reorganization; transcription, altered MAT1A(INDUCES) 32855301; 35337817; 9832506 4 52 21 +TERT TERT DNA-binding; EC 2.7.7.49; Nucleolus; Transferase O14746 7015 5p15.33 human Y707-p 450084 QDPPPELyFVKVDVT molecular association, regulation; intracellular localization apoptosis, altered RAN(INDUCES) 12808100; 18829466; 20211239; 24413564 5 0 0 +BECN1 beclin 1 Adaptor/scaffold; Autophagy; Membrane protein, peripheral Q14457 8678 17q21.31 human K263-ub 964501094 YAQTQLDkLKKTNVF protein stabilization; molecular association, regulation autophagy, inhibited beclin 1(INDUCES) 31848340 1 2 0 LATS1 induces inactive Beclin-1 dimerization and inhibition of autophagy +Ppp1r12a MYPT1 Motility/polarity/chemotaxis; PHOSPHATASE; Protein phosphatase, regulatory subunit Q10728 116670 7q21 rat S473-p 3174680 GVIRSASsPRLSSSL molecular association, regulation PLK1(INDUCES) 18477460 2 9 7 +KCNJ1 ROMK Channel, potassium; Membrane protein, integral; Membrane protein, multi-pass P48048 3758 11q24.3 human S4-p 2813507 ____MNAsSRNVFDT activity, induced; intracellular localization 12221079 2 0 0 +Dcx Doublecortin Cytoskeletal; Motility/polarity/chemotaxis Q9ESI7 84394 Xq33-q34 rat S332-p 451363 STPKSKQsPISTPTS cell growth, altered 21159948 7 4 14 controls axon branching morphogenesis +Nde1 NUDE1 Cell cycle regulation; Cytoskeletal; Microtubule-binding Q9CZA6 67203 16|16 A1 mouse Y279-p 448969 ASCRNFMyDQSPSRT NUDE_C molecular association, regulation PAFAH1B1(DISRUPTS) 29562183 1 9 250 +FUS hnRNP P2 iso2 DNA-binding; Nuclear receptor co-regulator; Oncoprotein; RNA splicing; RNA-binding; SUMO LIGASE P35637-2 2521 16p11.2 human K333-sm 580826268 DRETGKLkGEATVSF RRM_1 protein stabilization autophagy, inhibited 32069702 1 1 0 promotes hnRNPD-mediated ATG4D stability +ERBB2 HER2 EC 2.7.10.1; KINASE; Kinase, protein; Membrane protein, integral; Oncoprotein; Protein kinase, TK; Protein kinase, tyrosine (receptor) P04626 2064 17q12 human K716-ub 964518778 QAQMRILkETELRKV protein degradation; ubiquitination cell growth, inhibited 33875644 1 1 0 +NEDD4 NEDD4 iso4 EC 6.3.2.-; EC 6.3.2.19; Ligase; Nuclear receptor co-regulator; UBIQUITIN LIGASE; Ubiquitin conjugating system; Ubiquitin ligase P46934-4 4734 15q21.3 human T229-p 478103 PTPQDNLtDAENGNI molecular association, regulation; ubiquitination NDFIP1(INDUCES) 31578285 1 26 5 Regulates autoubiquitination +ATP5F1A ATP5A1 EC 3.6.3.14; Energy Metabolism - oxidative phosphorylation; Hydrolase; Membrane protein, integral; Mitochondrial; Transporter P25705 498 18q21.1 human Y243-p 461991 SDEKKKLyCIYVAIG ATP-synt_ab molecular association, regulation; phosphorylation carcinogenesis, induced; cell growth, induced; apoptosis, inhibited; autophagy, inhibited ATPIF1(DISRUPTS) 35895804 1 0 28 inhibits phosphorylation of downstream proteins +DBN1 DBN1 iso3 Actin-binding; Cytoskeletal; Motility/polarity/chemotaxis Q16643-3 1627 5q35.3 human S142-p 452446 NGLARLSsPVLHRLR intracellular localization cytoskeletal reorganization 24637538 6 87 28 Phospho-drebrin was localized at the distal part of total drebrin in the growth cone. +METTL3 METTL3 EC 2.1.1.62; METHYLTRANSFERASE; Methyltransferase; RNA processing Q86U44 56339 14q11.2 human S67-p 1876371800 GPKPSTAsAVPELAT molecular association, regulation transcription, induced; translation, induced EEF1G(INDUCES); Elf-2(INDUCES); RPSA(INDUCES) 35172162 1 1 0 +TERF2 TRF2 DNA repair, damage; DNA-binding Q15554 7014 16q22.1 human R72-me 10338218 SGRARRGrHEPGLGG cell cycle regulation; cell growth, altered 19596784 1 0 0 +SSTR5 SSTR5 Cell cycle regulation; GPCR, family 1; Membrane protein, integral; Membrane protein, multi-pass; Receptor, GPCR P35346 6755 16p13.3 human T247-p 1779800 RRSERKVtRMVLVVV 7tm_1 molecular association, regulation; receptor internalization, altered ARRB2(INDUCES) 18096696 1 0 0 +CHUK IKKA EC 2.7.11.10; KINASE; Kinase, protein; Protein kinase, Other; Protein kinase, Ser/Thr (non-receptor) O15111 1147 10q24.31 human T23-p 447780 EMRERLGtGGFGNVC Pkinase phosphorylation; enzymatic activity, induced apoptosis, altered; apoptosis, inhibited; transcription, induced; transcription, altered 12048203; 18515365; 18794113; 19609947 7 4 0 +ATF2 ATF-2 ACETYLTRANSFERASE; C2H2-type zinc finger protein; EC 2.3.1.48; Transcription factor P15336 1386 2q31.1 human T73-p 451439 ADQTPTPtRFLKNCE activity, induced; protein stabilization transcription, induced 15105425 4 10 9 +Mzf1 MZF-1 C2H2-type zinc finger protein; DNA-binding; Transcription factor O70162 109889 7 A1|7 7.73 cM mouse S374-p 448856 SLSGQIQsPTTEGGF activity, inhibited 12427756 1 0 0 S295A substitution correlates with increased transactivation activity, implying that phosphorylation can inhibit the transcriptional activation of MZF-2A. Substitution of three sites (S257/275/295A) further inhibited transcription, suggesting that phosphorylation of these three residues cooperatively inhibits transactivation. +CD28 CD28 Cell surface; Membrane protein, integral P10747 940 2q33.2 human Y209-p 450284 TRKHYQPyAPPRDFA activity, induced; molecular association, regulation; phosphorylation carcinogenesis, inhibited; cell growth, inhibited; transcription, induced; signaling pathway regulation CSK(INDUCES); Lck(INDUCES) 20368329; 21964608; 30131370; 31292214 7 8 276 +GYS1 GYS1 Carbohydrate Metabolism - starch and sucrose; EC 2.4.1.11; Transferase P13834 100008660 rabbit S645-p 448238 RPASVPPsPSLSRHS Glycogen_syn enzymatic activity, inhibited 10909964; 6402364; 7759494; 7929255; 8226927; 8546708 21 32 7 +CRTC2 TORC2 Transcription, coactivator/corepressor Q53ET0 200186 1q21.3 human S171-p 454622 SALNRTSsDSALHTS TORC_M transcription, inhibited 16684769 19 10 12 +GJA1 GJA1 Channel, misc.; Membrane protein, integral; Membrane protein, multi-pass; Motility/polarity/chemotaxis P17302 2697 6q22.31 human Y286-p 465296 SPMSPPGyKLVTGDR Connexin43 protein degradation; ubiquitination 24399133 1 2 11 +POLH POLH DNA repair, damage; EC 2.7.7.7; Transferase Q9Y253 5429 6p21.1 human K453-sm 1877365906 SDPSSLPkVPVTSSE intracellular localization; enzymatic activity, inhibited 32350109 1 1 0 +SOCS3 SOCS3 Inhibitor O14543 9021 17q25.3 human K6-ub 486270 __MVTHSkFPAAGMS protein degradation 12459551 1 0 0 +SCN5A SCN5A Channel, sodium; Membrane protein, integral; Membrane protein, multi-pass Q14524 6331 3p22.2 human Y1495-p 455660 TEEQKKYyNAMKKLG activity, induced; protein conformation; activity, inhibited 15831816; 34373326 2 0 0 Induce destabilization of the IFM peptide; leads to a depolarizing shift in steady state inactivation; regulates Nav1.5 function +Gata1 GATA1 DNA-binding; Transcription factor P17679 14460 X A1.1|X 3.59 cM mouse S142-p 451235 TLKTERLsPDLLTLG protein degradation; acetylation; ubiquitination; phosphorylation DNA(INDUCES) 16858405 3 0 0 Phosphorylation and acetylation cause the degradation of acetylated GATA-1; DNA binding is required for MAPK-dependent phosphorylation +TLR3 TLR3 Membrane protein, integral; Receptor, cytokine O15455 7098 4q35.1 human K831-ub 1877171200 DPLCKRFkVHHAVQQ TIR molecular association, regulation; intracellular localization signaling pathway regulation VPS36(INDUCES); STAM2(INDUCES); STAM1(INDUCES); Hrs(INDUCES) 32878999 1 0 0 TLR3-mediated signaling, TLR3 trafficking from the Golgi apparatus to endosomes, sorting of polyubiquitinated TLR3 by the ESCRT complexes +Ahcyl1 AHCYL1 Amino Acid Metabolism - cysteine and methionine; EC 3.3.1.1; Hydrolase; Other Amino Acids Metabolism - selenoamino acid Q80SW1 229709 3 F2.3|3 46.83 cM mouse S68-p 467244 RSLSRSIsQSSTDSY molecular association, regulation; phosphorylation PIP4K2A(INDUCES); PPP1CA(INDUCES); PIP5K1A(INDUCES); IP3R1(INDUCES) 16793548; 17635105; 26509711 6 1 1 +MAPK14 P38A EC 2.7.11.24; KINASE; Kinase, protein; Protein kinase, CMGC; Protein kinase, Ser/Thr (non-receptor) Q16539 1432 6p21.31 human K139-me 1884812101 YQILRGLkYIHSADI protein stabilization; enzymatic activity, induced 35992062 1 1 0 +Esr2 ER-beta DNA-binding; Nuclear receptor O08537 13983 12 C3|12 33.52 cM mouse S75-p 1023700 GPVRQTAsPNVLWPT ERbeta_N protein degradation; molecular association, regulation; ubiquitination; intracellular localization transcription, inhibited UBE3A(INDUCES) 17962381 1 0 0 +CDKN1A p21Cip1 Cell cycle regulation; Inhibitor P38936 1026 6p21.2 human R156-m2 50760801 DFYHSKRrLIFSKRK intracellular localization 26436589 1 0 0 cytoplasmic localization of p21 +Fzd3 FZD3 GPCR, Fz/Smo family; Membrane protein, integral; Membrane protein, multi-pass; Receptor, GPCR Q61086 14365 14 D1|14 34.09 cM mouse S509-p 18507007 KTCFEWAsFFHGRRK Frizzled receptor internalization, inhibited; phosphorylation endocytosis, inhibited 21316586 1 0 0 enhances PCP signaling, regulating c-Jun phosphorylation, and affecting growth cone guidance +Cacng2 Stargazin Channel, calcium; Membrane protein, integral; Membrane protein, multi-pass Q71RJ2 84347 7q34 rat S249-p 455320 RSTEPSHsRDASPVG molecular association, regulation neural plasticity PSD-95(INDUCES) 25843401 3 1 1 +TIFA TIFA Q96CG3 92610 4q25 human T177-p 4743087 SSQSSSPtEMDENES molecular association, regulation; phosphorylation signaling pathway regulation TRAF6(DISRUPTS) 36098982 1 2 0 inhibits IKK and MAPK phosporylation; regulates ADP-heptose signaling +Cask CASK Adaptor/scaffold; EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, CAMK; Protein kinase, Ser/Thr (non-receptor) Q62915 29647 Xq12 rat K679-sm 3173812 CIAMEKTkQEQQASC molecular association, regulation; intracellular localization cytoskeletal reorganization ACTB(DISRUPTS); EPB41(DISRUPTS) 18606847 1 0 0 +CIITA CIITA DNA-binding; EC 2.7.11.1; KINASE; Protein kinase, Ser/Thr (non-receptor); Transcription, coactivator/corepressor P33076 4261 16p13.13 human S288-p 2286408 PDRPGSTsPFAPSAT molecular association, regulation; intracellular localization; activity, inhibited transcription, altered Exportin-1(INDUCES) 15210796; 18245089 2 0 0 +TPI1 TPI1 Carbohydrate Metabolism - fructose and mannose; Carbohydrate Metabolism - glycolysis and gluconeogenesis; Carbohydrate Metabolism - inositol phosphate; EC 5.3.1.1; Isomerase P60174 7167 12p13.31 human S21-p 465652 KMNGRKQsLGELIGT TIM molecular association, regulation carcinogenesis, inhibited TPI1(DISRUPTS) 36715544 3 67 124 +TTK TTK Cancer Testis Antigen (CTA); EC 2.7.12.1; KINASE; Kinase, protein; Protein kinase, Other; Protein kinase, dual-specificity (non-receptor) P33981 7272 6q14.1 human T686-p 487541 VKDSQVGtVNYMPPE Pkinase enzymatic activity, induced cell cycle regulation 17728254; 18545697; 18680479; 19120698 9 5 0 +GRIK2 GluR6 Channel, calcium; Channel, ligand-gated; Membrane protein, integral; Membrane protein, multi-pass Q13002 2898 6q16.3 human S868-p 478417 MVEELRMsLKCQRRL sumoylation; receptor internalization, induced; receptor recycling, induced; intracellular localization; phosphorylation; palmitoylation neural plasticity; endocytosis, altered 22522402; 37868810 7 0 0 PMA induced colocalization with EEA1 and TfR, and S868 phosphorylation increases recycling of GluKR6 ; palmitoylation maintains surface expression and regulates agonist -induced internalisation; long-term depression (LTD) of KAR receptor mediated synaptic transmission +MAVS MAVS Adaptor/scaffold; Membrane protein, integral Q7Z434 57506 20p13 human S442-p 58984003 CFEDLAIsASTSLGM molecular association, regulation; phosphorylation signaling pathway regulation IRF3(INDUCES) 25636800; 31461653 2 1 0 induces phosphorylation of IRF3, regulates IFN signaling; induces IFN production +Stk24 MST3 EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, STE; Protein kinase, Ser/Thr (non-receptor) Q99KH8 223255 14 E5|14 64.95 cM mouse S79-p 33602703 TVLSQCDsPYVTKYY Pkinase cell motility, induced 24872548 1 0 0 +WASF2 WAVE2 Actin-binding; Motility/polarity/chemotaxis Q9Y6W5 10163 1p36.11 human S482-p 6377642 RRIAVEYsDSEDDSS activity, inhibited cytoskeletal reorganization 19012317 1 0 0 +NUP50 NUP50 Nuclear import; Nucleoporin Q9UKX7 10762 22q13.31 human S221-p 476622 KVAAETQsPSLFGST molecular association, regulation KPNB1(DISRUPTS) 19767751 1 32 18 +DAB2 DAB2 Adaptor/scaffold; Tumor suppressor P98082 1601 5p13.1 human S401-p 452352 SPNPFVGsPPKGLSI molecular association, regulation CLTA(INDUCES) 21097498 2 41 0 +MSX2 MSX2 DNA-binding; Transcription, coactivator/corepressor P35548 4488 5q35.2 human T135-p 25554905 HMSPTTCtLRKHKTN protein stabilization cell differentiation, inhibited; transcription, inhibited 22633971 1 0 0 +Gabrg2 GABRG2 Channel, chloride; Channel, ligand-gated; Membrane protein, integral; Membrane protein, multi-pass; Transporter; Transporter, ion channel Q6PW52 29709 10q21 rat S329-p 1869465807 RKSLPKVsYVTAMDL Neur_chan_memb intracellular localization neural plasticity; signaling pathway regulation 31618635 1 0 0 Nogo-A signaling +P2rx1 P2X1 Channel, ligand-gated; Membrane protein, integral; Membrane protein, multi-pass P47824 rat T18-p 3251800 AFFFEYDtPRMVLVR P2X_receptor activity, induced 14614959 1 0 0 T18A and T19N mutations abolishes receptor current. +CDKN1B p27Kip1 Cell cycle regulation; Inhibitor; Oncoprotein; Protein kinase, regulatory subunit P46527 1027 12p13.1 human K153-ub 5018204 EQCAGIRkRPATDDS protein degradation cell cycle regulation 10318797; 19056892 2 1 0 +Ikbkb IKKB EC 2.7.11.10; KINASE; Kinase, protein; Protein kinase, Other; Protein kinase, Ser/Thr (non-receptor) O88351 16150 8|8 A2 mouse S705-p 17934902 LPESDKKsEELVAEA molecular association, regulation; phosphorylation PPP2R3C(INDUCES) 20925653 1 0 0 interaction with PPP2R3C (aka G4-1) downregulates IKK-beta activity; S181 phosphorylation increased in S679/682/689/692/697/701/705A mutant +MYH10 MYH10 iso2 Motility/polarity/chemotaxis; Motor P35580-2 4628 17p13.1 human K1104-ub 52485012 LKLQLAKkEEELQGA Myosin_tail_1 protein degradation 26676607 0 1 0 +CRYAB CRYAB Chaperone; Heat shock protein Q7M2W6 100519789 pig S59-p 448783 PSFLRAPsWIDTGLS intracellular localization 15878345 46 22 0 +GYS1 GYS1 Carbohydrate Metabolism - starch and sucrose; EC 2.4.1.11; Transferase P13807 2997 19q13.33 human S649-p 448239 VPPSPSLsRHSSPHQ Glycogen_syn activity, inhibited 22510711 14 15 1 +FOXM1 FOXM1 iso2 DNA-binding; Transcription factor Q08050-2 2305 12p13.33 human K341-sm 31898505 LRRNMTIkTELPLGA protein degradation transcription, inhibited 25533473 2 1 0 +Pdha1 PDHA1 Amino Acid Metabolism - valine, leucine and isoleucine biosynthesis; Carbohydrate Metabolism - butanoate; Carbohydrate Metabolism - citrate (TCA) cycle; Carbohydrate Metabolism - glycolysis and gluconeogenesis; Carbohydrate Metabolism - pyruvate; EC 1.2.4.1; Mitochondrial; Oxidoreductase P35486 18597 X F4|X 73.95 cM mouse S293-p 448258 TYRYHGHsMSDPGVS E1_dh activity, induced; acetylation; enzymatic activity, inhibited cell cycle regulation; cell differentiation, altered; carcinogenesis, altered 23290136; 25991547; 26930489; 27856638; 30429315; 30745576; 31242425; 31435015; 33826891; 34385317; 36211560 96 108 675 regulates histones acetylation +PIP5K1C PIP5K1C Carbohydrate Metabolism - inositol phosphate; EC 2.7.1.68; Kinase, lipid; Motility/polarity/chemotaxis O60331 23396 19p13.3 human Y649-p 450241 TDERSWVySPLHYSA molecular association, regulation; phosphorylation talin 1(INDUCES); AP-2 beta(INDUCES) 15738269; 16616931; 20850356 6 0 0 stimulates PIP5KG polarization +HNRNPL hnRNP L RNA splicing; RNA-binding P14866 3191 19q13.2 human S52-p 3180663 GRYYGGGsEGGRAPK carcinogenesis, altered; cell growth, altered 20972334 1 20 3 regulates the alternative splicing of caspase-9 +Sell SELL Membrane protein, integral P18337 20343 1 H2.2|1 71.37 cM mouse S364-p 40548101 RLKKGKKsQERMDDP molecular association, regulation AP1M1(DISRUPTS) 28235798 2 0 0 Abolishes interaction with AP1M1 +Eef1a1 EEF1A1 Nucleolus; Translation; Translation elongation P10126 13627 9|9 E1 mouse K165-m3 15382301 TEPPYSQkRYEEIVK GTP_EFTU molecular association, regulation translation, altered EEF1D(DISRUPTS); eEF1B(DISRUPTS); EEF1G(DISRUPTS) 28108655 1 3 3 +DDX19B DDX19B EC 3.6.4.13; Helicase; RNA-binding Q9UMR2 11269 16q22.1 human S93-p 27447125 SPLYSVKsFEELRLK molecular association, regulation; intracellular localization NUP214(DISRUPTS) 28314779 2 5 0 localization at the nuclear pore, R-loop suppression +CCNY CBCP1 Cell cycle regulation Q8ND76 219771 10p11.21 human S71-p 4750438 RASTIFLsKSQTDVR protein degradation; ubiquitination 24794231 1 2 5 +MAT2A MAT2A Amino Acid Metabolism - cysteine and methionine; EC 2.5.1.6; Other Amino Acids Metabolism - selenoamino acid; Transferase P31153 4144 2p11.2 human K340-sm 50455000 FHYGTSQkSERELLE S-AdoMet_synt_C protein stabilization; molecular association, regulation cell growth, induced; apoptosis, inhibited; transcription, induced Bcl-2(INDUCES) DNA(INDUCES) 26416353 1 0 0 +SLC3A2 SLC3A2 Membrane protein, integral; Transporter P08195 6520 11q12.3 human S406-p 6003504 LLTSSYLsDSGSTGE cell adhesion, altered 19065266 1 1 0 enhances cell- cell interactions +SQSTM1 SQSTM1 Autophagy; Nuclear receptor co-regulator; Ubiquitin conjugating system Q13501 8878 5q35.3 human T269-p 457004 GGKRSRLtPVSPESS protein degradation; molecular association, regulation; ubiquitination; intracellular localization cell cycle regulation; carcinogenesis, induced; carcinogenesis, altered; autophagy, inhibited; signaling pathway regulation mTOR(INDUCES); LC3B(DISRUPTS); Raptor(INDUCES); TRAF6(INDUCES) 20974803; 26279575; 35840557 9 74 136 +Nos1 nNOS Amino Acid Metabolism - arginine and proline; EC 1.14.13.39; Oxidoreductase P29476 24598 12q16 rat K245-ac 2459106 DLDGKSHkAPPLGGD activity, induced 18415985 1 1 0 +Klf7 KLF7 C2H2-type zinc finger protein; DNA-binding Q99JB0 93691 1|1 C2 mouse K227-ac 56423805 CQFNGCRkVYTKSSH zf-C2H2 cell cycle regulation; cell growth, inhibited; transcription, induced 26930448 1 0 0 +CAVIN1 PTRF Transcription initiation complex Q6NZI2 284119 17q21.2 human K291-ac 1873356106 AERREKLkTSRDKLR PTRF_SDPR molecular association, regulation; intracellular localization HSL(INDUCES) 28559430 1 1 0 induces lipolysis +BCAT2 BCAT2 Amino Acid Metabolism - valine, leucine and isoleucine biosynthesis; Amino Acid Metabolism - valine, leucine and isoleucine degradation; Cofactor and Vitamin Metabolism - pantothenate and CoA biosynthesis; EC 2.6.1.42; Mitochondrial; Transferase O15382 587 19q13.33 human K44-ac 11322721 LQLEMTQkPHKKPGP protein degradation 32467562 1 2 0 +GNAI1 G-alpha i1 G protein; G protein, heterotrimeric; G protein, heterotrimeric alpha G((i/o/t/z)) P63096 2770 7q21.11 human Y155-p 5688819 LNDSAAYyLNDLDRI G-alpha enzymatic activity, induced carcinogenesis, induced; signaling pathway regulation 33139573 1 1 1 +NOS3 eNOS Amino Acid Metabolism - arginine and proline; EC 1.14.13.39; Oxidoreductase P29474 4846 7q36.1 human Y81-p 456466 WEVGSITyDTLSAQA enzymatic activity, induced 32653904 5 2 0 +RIPK3 RIPK3 EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, Ser/Thr (non-receptor); Protein kinase, TKL Q9Y572 11035 14q12 human S164-p 27928503 KLADFGLsTFQGGSQ Pkinase enzymatic activity, inhibited; phosphorylation 35739084 3 2 0 inhibits MLKL phosphorylation and necroptosis +OSMR OSMR Membrane protein, integral; Receptor, cytokine Q99650 9180 5p13.1 human Y839-p 475364 LTKPNYLyLLPTEKN phosphorylation 18430728 2 1 7 important for STAT5B activation +IFNAR1 IFNAR1 Membrane protein, integral; Receptor, cytokine P17181 3454 21q22.11 human S539-p 52427502 SQDSGNYsNEDESES protein degradation; ubiquitination 26676772 1 0 0 +Rab9a RAB9A G protein; G protein, monomeric; G protein, monomeric, Rab Q9R0M6 56382 X|X F5 mouse S179-p 3191548 ILATEDRsEHLIQTD molecular association, regulation; intracellular localization; phosphorylation autophagy, induced; signaling pathway regulation RIPK1(INDUCES) 30511961; 35018428 2 13 0 +CEBPB C/EBP-beta DNA-binding; Motility/polarity/chemotaxis; Transcription factor P17676 1051 20q13.13 human S223-p 2902801 VPSGSSGsLSTSSSS protein conformation 22080951 2 2 0 +TRIM32 TRIM32 EC 6.3.2.-; EC 6.3.2.19; Ligase; UBIQUITIN LIGASE; Ubiquitin conjugating system; Ubiquitin ligase Q13049 22954 9q33.1 human S328-p 2049721 TFREMDMsPEEVVAS intracellular localization cell growth, inhibited 25100564 2 13 0 promotes Asymmetric Cell Division +KCNA5 Kv1.5 Channel, potassium; Membrane protein, integral; Membrane protein, multi-pass P22460 3741 12p13.32 human K221-sm 3144800 REDEGFIkEEEKPLP activity, induced 17261810 1 0 0 +EGFR EGFR EC 2.7.10.1; KINASE; Kinase, protein; Membrane protein, integral; Oncoprotein; Protein kinase, TK; Protein kinase, tyrosine (receptor) P00533 1956 7p11.2 human T430-p 1876620106 LEIIRGRtKQHGQFS Recep_L_domain enzymatic activity, inhibited carcinogenesis, inhibited; cell growth, inhibited 35226996 1 0 0 +NOS3 eNOS Amino Acid Metabolism - arginine and proline; EC 1.14.13.39; Oxidoreductase P29473 287024 cow T1177-p 467803 EVTSRIRtQSFSLQE phosphorylation; enzymatic activity, induced 16980435 2 11 8 stimulates VASP S236 phosphorylation in the presence of angiotensin 2 (AngII) +CDC37 CDC37 Chaperone Q16543 11140 19p13.2 human Y298-p 451691 GLDPVEVyESLPEEL CDC37_C molecular association, regulation CDK4(DISRUPTS); RAF1(DISRUPTS) 22727666 1 3 143 +Tbx21 TBX21 DNA-binding; Transcription factor Q9JKD8 57765 11|11 D mouse T302-p 27930807 ETQFIAVtAYQNAEI T-box transcription, inhibited 23616576 1 0 0 suppresses NFAT1 expression, critical for inhibition of NFAT1-mediated IL-2 and Th2 cytokine production +GHR GH receptor Membrane protein, integral; Receptor, cytokine P19941 100009325 rabbit Y627-p 486258 EFLSSCGyVSTDQLN molecular association, regulation STAT5A(INDUCES); STAT5B(INDUCES) 17666591 3 0 0 +Dnajb4 DNAJB4 Chaperone Q9D832 67035 3|3 H3 mouse Y172-p 450786 KVSLEEIySGCTKRM DnaJ_C molecular association, regulation carcinogenesis, inhibited Src iso1(INDUCES) 27065329 1 14 471 complex suppressing cancer invasion +Pde4d PDE4D EC 3.1.4.53; Nucleotide Metabolism - purine; Phosphodiesterase Q01063 238871 13 D2.1|13 59.69 cM mouse S141-p 483645 SDSDYDLsPKSMSRN phosphorylation; enzymatic activity, induced 25918234 1 28 5 regulates CAMP concentration and insulin secretion, regulates phosphorylation of CRTCs +Otud5 OTUD5 DEUBIQUITINASE; EC 3.4.19.12; Protease; Ubiquitin-specific protease Q3U2S4 54644 X A1.1|X 3.54 cM mouse S332-p 1870773110 HRNIHYNsVVNPNKA OTU protein degradation; protein stabilization; molecular association, regulation; ubiquitination; phosphorylation; enzymatic activity, induced cell cycle regulation; cell growth, induced; autophagy, inhibited; transcription, altered; signaling pathway regulation BTRC(DISRUPTS) 33110214 1 1 0 inhibits ubiquitination and induces stabilization of OTUD5 and BTRCP1 further causing DEPTOR degradation, regulates phosphorylation of mTOR targets, promotes OTUD5-?TrCP1-DEPTOR pathway +OGG1 OGG1 DNA repair, damage; Deoxyribonuclease; EC 4.2.99.18; Lyase O15527 4968 3p25.3 human S326-p 10036103 FSADLRQsRHAQEPP enzymatic activity, inhibited 19674107 1 0 0 +CXCR4 CXCR4 GPCR, family 1; Membrane protein, integral; Membrane protein, multi-pass; Receptor, GPCR P61073 7852 2q22.1 human Y157-p 455337 LLAEKVVyVGVWIPA 7tm_1; TM phosphorylation transcription, altered 15615703 1 0 0 +CCND1 CCND1 Activator; Cell cycle regulation; Nuclear receptor co-regulator; Oncoprotein P24385 595 11q13.3 human T286-p 447839 EEVDLACtPTDVRDV protein degradation; molecular association, regulation; ubiquitination; intracellular localization cell cycle regulation; carcinogenesis, inhibited; cell growth, induced; apoptosis, induced; cell growth, inhibited; cell growth, altered AMBRA1(INDUCES); BTRC(INDUCES); CDK2(DISRUPTS); WDR77(DISRUPTS); FBXO31(INDUCES); CDK4(DISRUPTS); SMARCA4(DISRUPTS); Exportin-1(INDUCES); CRYAB(INDUCES); PRMT5(DISRUPTS) 10766840; 11751903; 15735756; 16153639; 16504004; 16732330; 17046823; 17081987; 18650423; 19412162; 19767775; 20951943; 24119401; 33521925; 33854232; 33854239; 36106050; 37301510 35 5 1 +NFATC1 NFAT2 DNA-binding; Transcription factor O95644 4772 18q23 human T339-p 1869090805 PVKSRKTtLEQPPSV activity, induced carcinogenesis, induced; cell motility, induced; transcription, induced 31730483 1 0 0 multiple sites mutatnt +SCN8A SCN8A Channel, sodium; Membrane protein, integral; Membrane protein, multi-pass Q9UQD0 6334 12q13.13 human S641-p 1869659202 RRSVKRNsTVDCNGV Na_trans_cytopl activity, inhibited neural plasticity 32611770 1 1 0 Regulates voltage-gated sodium channel Nav1.6 activity and neuronal excitability +DNMT1 DNMT1 iso2 Amino Acid Metabolism - cysteine and methionine; Cell development/differentiation; EC 2.1.1.37; METHYLTRANSFERASE; Methyltransferase; Methyltransferase, DNA; Transcription regulation P26358-2 1786 19p13.2 human S730-p 452655 DNIPEMPsPKKMHQG molecular association, regulation; protein conformation; activity, inhibited RBBP7(INDUCES) 28143904 4 69 10 +Pag1 PAG Adaptor/scaffold; Membrane protein, integral Q9JM80 64019 2q23 rat Y314-p 450659 EEEISAMySSVNKPG PAG molecular association, regulation; intracellular localization cell cycle regulation; cell differentiation, altered; cytoskeletal reorganization; cell adhesion, altered SOCS1(NOT_REPORTED); CTK(INDUCES); CSK(INDUCES); CSK(NOT_REPORTED); SOCS1(INDUCES) 10801129; 10918051; 16920712; 19124084 9 31 643 +INSR INSR EC 2.7.10.1; KINASE; Kinase, protein; Membrane protein, integral; Protein kinase, TK; Protein kinase, tyrosine (receptor) P06213 3643 19p13.2 human Y1355-p 447683 SLGFKRSyEEHIPYT protein conformation; enzymatic activity, induced cell cycle regulation; cell growth, altered 10805733; 10852715; 10940390; 1618780; 1654097 15 5 2 antibodies against Y1355 and Y1361 peptides stimulated cell proliferation. ; decreases ERK activation; regulates cell proliferation in response to insulin but not IGF-1 on pp120 +H4C1 H4 DNA-binding P62805 8359 6p22.2 human K77-ac 3607639 VTYTEHAkRKTVTAM CENP-T_C molecular association, regulation polybromo 1(INDUCES) 20368734 1 5 95 varying site specificity binding for each bromodomain 1-6 +Yy1 YY1 C2H2-type zinc finger protein; Cell development/differentiation; Transcription factor Q00899 22632 12 F1|12 59.58 cM mouse S120-p 460025 EVVGGDDsDGLRAED molecular association, regulation RNA(INDUCES); RNA(DISRUPTS) 28834756 3 34 0 +LRP1 LRP1 Cell surface; Membrane protein, integral; Motility/polarity/chemotaxis; Receptor, misc. Q07954 4035 12q13.3 human Y4473-p 473712 VEIGNPTyKMYEGGE molecular association, regulation SNX17(DISRUPTS); SHP-2(INDUCES) 18381291 4 3 2 +Pdha1 PDHA1 Amino Acid Metabolism - valine, leucine and isoleucine biosynthesis; Carbohydrate Metabolism - butanoate; Carbohydrate Metabolism - citrate (TCA) cycle; Carbohydrate Metabolism - glycolysis and gluconeogenesis; Carbohydrate Metabolism - pyruvate; EC 1.2.4.1; Mitochondrial; Oxidoreductase P26284 29554 Xq14 rat S293-p 448258 TYRYHGHsMSDPGVS E1_dh acetylation; enzymatic activity, altered 34360775 96 108 675 regulates acetylation of brain proteins +TERF1 TRF1 DNA-binding P54274 7013 8q21.11 human S435-p 3192037 KKLKLISsDSED___ apoptosis, induced DNA(INDUCES) 18625707 1 5 0 enhances binding of TRF1 to telomeric DNA in vivo and in vitro; regulated by phosphorylation of sites T344 and T371 by Cdc2 +Itch ITCH EC 6.3.2.-; EC 6.3.2.19; Ligase; UBIQUITIN LIGASE; Ubiquitin conjugating system; Ubiquitin ligase Q8C863 16396 2 H1|2 76.94 cM mouse S199-p 459622 KRANGNNsPSLSNGG activity, induced; protein stabilization; protein conformation 16446428 1 6 0 +ERBB4 HER4 EC 2.7.10.1; KINASE; Kinase, protein; Membrane protein, integral; Protein kinase, TK; Protein kinase, tyrosine (receptor) Q15303 2066 2q34 human Y984-p 34494908 MARDPQRyLVIQGDD molecular association, regulation STAT5A(INDUCES); SHP-2(INDUCES) 16729043 1 0 0 +Irs1 IRS1 Adaptor/scaffold; Motility/polarity/chemotaxis P35570 25467 9q34 rat S422-p 40511593 PSDGGFIsSDEYGSS protein degradation; molecular association, regulation; ubiquitination; phosphorylation cell growth, inhibited; apoptosis, induced; signaling pathway regulation BTRC(INDUCES) 30240640 1 2 0 inhibits phosphorylation of Akt and FOXO1/3a, PI3K/Akt pathway +Sstr2 SSTR2 GPCR, family 1; Membrane protein, integral; Membrane protein, multi-pass; Receptor, GPCR P30680 rat T359-p 12577700 ETTETQRtLLNGDLQ activity, induced; intracellular localization; receptor internalization, altered signaling pathway regulation 20051480; 21795688 6 0 0 Dephosphorylation is initiated directly after receptor activation at or near the plasma membrane; leads to disruption of the ?-arrestin- GPCR complex +LRRK2 LRRK2 EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, Ser/Thr (non-receptor); Protein kinase, TKL Q5S007 120892 12q12 human S2032-p 3306338 CRMGIKTsEGTPGFR Pkinase enzymatic activity, induced 20595391 5 2 0 +ACLY ACLY Carbohydrate Metabolism - citrate (TCA) cycle; EC 2.3.3.8; Lyase; Transferase P53396 47 17q21.2 human Y252-p 462909 EAYPEEAyIADLDAK Citrate_bind acetylation; enzymatic activity, induced carcinogenesis, induced 32420483 1 1 1 +Grin1 NMDAR1 Channel, calcium; Channel, ligand-gated; Membrane protein, integral; Membrane protein, multi-pass P35438 14810 2 A3|2 17.14 cM mouse S896-p 448255 SSFKRRRsSKDTSTG neural plasticity 34666797 24 0 0 +Nos1 nNOS Amino Acid Metabolism - arginine and proline; EC 1.14.13.39; Oxidoreductase P29476 24598 12q16 rat S741-p 452159 LAEAVKFsAKLMGQA enzymatic activity, inhibited 15251453 1 0 0 +STAT5B STAT5B DNA-binding; Oncoprotein; Transcription factor P51692 6777 17q21.2 human Y725-p 448734 AGGGSATyMDQAPSP transcription, induced 16772534 3 0 1 +NFKB1 NFkB-p105 iso2 DNA-binding; Transcription factor P19838-2 4790 4q24 human Y90-p 1880539210 PQVKICNyVGPAKVI molecular association, regulation transcription, altered DNA(INDUCES) 36534507 1 0 0 +RACK1 RACK1 Adaptor/scaffold; G protein; G protein, heterotrimeric; G protein, heterotrimeric beta; Motility/polarity/chemotaxis; Nuclear receptor co-regulator P63244 10399 5q35.3 human Y246-p 451481 LCFSPNRyWLCAATG WD40 protein stabilization; molecular association, regulation; ubiquitination; intracellular localization; activity, inhibited; phosphorylation translation, altered; carcinogenesis, inhibited; cell adhesion, induced; cell motility, altered; cell motility, inhibited; transcription, inhibited; endocytosis, inhibited ZBP1(INDUCES); Src(INDUCES); Src(NOT_REPORTED) 12400005; 16849317; 17574549; 21685945; 22523568 6 1 1 Release of beta-actin mRNA; decreases phosphorylation of E-cadherin, B-catenin, p120 catenin and actin and localises them to cell-to-cell contacts, prevents ubiquitination of E-cadherin further inducing its stabilization, inhibits E-cadherin endocytosis +Papola PAP-alpha EC 2.7.7.19; RNA processing; RNA splicing; Transferase Q61183 18789 12|12 E mouse S537-p 1737605 DNSMSVPsPTSAMKT enzymatic activity, induced 18084034 1 5 0 in vitro and in vivo +FANCE FANCE DNA repair, damage Q9HB96 2178 6p21.31 human T346-p 476781 LGLLRLCtWLLALSP FA_FANCE protein degradation; molecular association, regulation; intracellular localization FANCD2(INDUCES) 17296736 2 0 0 required for mitomycin C resistance +ITGAL ITGAL Cell adhesion; Cell surface; Membrane protein, integral; Motility/polarity/chemotaxis P20701 3683 16p11.2 human S1165-p 2887600 LHEKDSEsGGGKD__ activity, induced; molecular association, regulation; intracellular localization; phosphorylation cell motility, induced; cell adhesion, induced; cytoskeletal reorganization; cell adhesion, altered 14-3-3 beta(INDUCES); FLNA(DISRUPTS); ICAM1(INDUCES); ACTN1(INDUCES); talin 1(INDUCES) 16301335; 29903913 2 1 0 induces phosphorylation of T758 of ITGB2, regulates localization of alpha actinin +Cdc37 CDC37 Chaperone Q63692 114562 8q13 rat S13-p 450034 VWDHIEVsDDEDETH CDC37_N molecular association, regulation; intracellular localization ICK(INDUCES); MOK(INDUCES); Src(INDUCES); MAK(INDUCES); CDK4(INDUCES); Akt1(INDUCES); RAF1(INDUCES); AurB(INDUCES) 15082798; 17922836 13 29 0 S13 phosphorylated Cdc37 colocalized with HSP90 in membrane ruffles and is associated with HSP90 kinase complexes. +Ncoa3 SRC-3 ACETYLTRANSFERASE; Acetyltransferase; EC 2.3.1.48; Motility/polarity/chemotaxis; Nuclear receptor co-regulator; Transcription, coactivator/corepressor O09000 17979 2|2 H3 mouse R844-me 2363407 SVRPPYNrAVSLDSP protein degradation transcription, inhibited CBP(INDUCES) 17043108 1 0 0 +NFE2L2 NRF2 DNA-binding; Transcription factor Q16236 4780 2q31.2 human S577-p 10292702 DEDGKPYsPSEYSLQ molecular association, regulation; intracellular localization transcription, induced PIN1(INDUCES) 19668370; 34918396 2 2 0 moderate effects observed only in NFE2L2-5A mutant +Bcl2l11 BIM Apoptosis O88498 64547 3q36 rat S109-p 449069 APMSCDKsTQTPSPP apoptosis, induced 12388545 1 1 0 +Marcks MARCKS Actin-binding; Motility/polarity/chemotaxis P26645 17118 10 B1|10 19.49 cM mouse S152-p 447786 KKKKKRFsFKKSFKL MARCKS receptor internalization, induced; intracellular localization carcinogenesis, induced; cell motility, altered 20211725; 34556581 26 15 10 +GRIN2A NMDAR2A Channel, ligand-gated; Membrane protein, integral; Membrane protein, multi-pass Q12879 2903 16p13.2 human S1459-p 481117 RVYKKMPsIESDV__ NMDAR2_C molecular association, regulation; receptor recycling, induced neural plasticity SNX27(INDUCES); PSD-95(DISRUPTS) 32877683; 34233182 2 8 2 +Arrb2 ARRB2 Adaptor/scaffold Q91YI4 216869 11 B3|11 42.99 cM mouse K108-ub 6140807 LQDRLLKkLGQHAHP Arrestin_N molecular association, regulation mAChR M2(INDUCES); mAChR m1(INDUCES) 19055777 1 1 0 +MAP1LC3C LC3C Autophagy; Microtubule-binding; Ubiquitin-like modifier; Vesicle Q9BXW4 440738 1q43 human S93-p 1869546300 YLLVNNKsLVSMSAT ATG8 molecular association, regulation apoptosis, induced ATG4B(DISRUPTS) 31709703 1 1 0 ; including ATG4A, ATG4C, ATG4D +HMGA1 HMGA1 iso2 DNA-binding P17096-2 3159 6p21.31 human K60-ac 458953 SKNKGAAkTRKTTTT apoptosis, induced 11389094 4 2 0 +OGT OGT EC 2.4.1.255; Glycan Metabolism - O-glycan biosynthesis; O-GlcNAc TRANSFERASE; Transferase O15294 8473 Xq13.1 human S4-p 27713501 ____MASsVGNVADS enzymatic activity, induced 23395175 1 1 0 +Cgas cGAS EC 2.7.7.86 Q8C6L5 214763 9|9 E1 mouse K382-sm 62952701 LNNHGIEkTCCESSG enzymatic activity, inhibited transcription, inhibited; signaling pathway regulation DNA(DISRUPTS) 28095500 1 0 0 regulation of STING signaling pathway +ECT2 ECT2 iso2 GEF; GEF, Rac/Rho; Motility/polarity/chemotaxis Q9H8V3-2 1894 3q26.31 human T327-p 483847 YLYEKANtPELKKSV molecular association, regulation cytoskeletal reorganization PLK1(INDUCES); RHOA(INDUCES) 28692064 2 18 8 cytoskeletal rearrangements during interphase +IGF1R IGF1R EC 2.7.10.1; KINASE; Kinase, protein; Membrane protein, integral; Protein kinase, TK; Protein kinase, tyrosine (receptor) P08069 3480 15q26.3 human K1130-sm 12723517 MAYLNANkFVHRDLA PK_Tyr_Ser-Thr intracellular localization cell growth, induced; transcription, induced DNA(INDUCES) 20145208; 25448401 2 0 0 +CD33 CD33 Cell adhesion; Membrane protein, integral P20138 945 19q13.41 human Y358-p 450953 SKDTSTEySEVRTQ_ molecular association, regulation SHP-2(INDUCES) 10887109 2 0 3 While tyrosine phosphorylation of CD33 was shown to induce its interaction in cells with SHP-1 and SHP-2, the specific contribution of Y358 phosphorylation to CD33 interaction with SHP-2 was based on in vitro binding experiments. +RB1 Rb Nuclear receptor co-regulator; Oncoprotein; Transcription, coactivator/corepressor; Tumor suppressor P06400 5925 13q14.2 human S567-p 450021 SLAWLSDsPLFDLIK RB_A protein degradation; molecular association, regulation; activity, inhibited cell growth, induced; apoptosis, induced; apoptosis, inhibited MDM2(INDUCES) 12646568; 20871633; 22279936; 31163228 6 0 0 dephosphorylation of Rb induced cell death +TNKS TNKS EC 2.4.2.30; Transferase O95271 8658 8p23.1 human T839-p 21326702 DTQGRNStPLHLAAG Ank_4 protein stabilization; intracellular localization; enzymatic activity, induced cell cycle regulation; cell growth, induced 21818122 1 0 0 +Csf3r GCSFR Membrane protein, integral; Receptor, cytokine P40223 12986 4 D2.2|4 59.77 cM mouse Y753-p 451834 RTGDQVLyGQVLESP activity, induced 7489718 5 0 0 Receptors mutant for Y728 or Y753 could neither transduce growth-inhibitory signals nor induce the neutrophil-specific myeloperoxidase (MPO) gene. +NFATC1 NFAT2 DNA-binding; Transcription factor O95644 4772 18q23 human K702-sm 6413902 PANVPIIkTEPTDDY molecular association, regulation; intracellular localization chromatin organization, altered; signaling pathway regulation; transcription, inhibited HDAC1(INDUCES); HDAC2(INDUCES); PML(INDUCES); HDAC4(INDUCES) 19218564; 32986812 2 1 0 K702/914R and K349/702/914R mutants prevented sumoylation in mice, increased IL-2 secretion counteracted IL-17 and IFN-gamma expression +DOK1 DOK1 Adaptor/scaffold; Motility/polarity/chemotaxis Q99704 1796 2p13.1 human Y315-p 448904 CPSQDSLySDPLDST molecular association, regulation RASA1(INDUCES) 10688886 1 26 331 +CTDP1 CTDP1 EC 3.1.3.16; Motility/polarity/chemotaxis; PHOSPHATASE; Protein phosphatase, Ser/Thr (non-receptor); Transcription initiation complex Q9Y5B0 9150 18q23 human S944-p 455467 NEDEGSSsEADEMAK FCP1_C molecular association, regulation; enzymatic activity, induced transcription, altered GTF2F1(INDUCES) 15723518; 19215094 2 0 1 +CPSF3 CPSF3 EC 3.1.27.-; RNA processing; RNA splicing; RNA-binding; Ribonuclease Q9UKF6 51692 2p25.1 human K462-sm 2586339 TLNFRGEkLAKVMGF RNA splicing, altered; cell growth, induced 17923699 1 0 0 regulation of mRNA 3'-end processing- cleavage and polyadenylation +Dpysl2 CRMP-2 Microtubule-binding; Motility/polarity/chemotaxis P47942 25416 15p12 rat T555-p 448084 DNIPRRTtQRIVAPP activity, inhibited cell growth, inhibited 16595691; 26804001 19 2 8 +PPP1R14A PPP1R14A Inhibitor; Protein phosphatase, regulatory subunit BAA22995 397610 pig T38-p 449098 QKRHARVtVKYDRRE PP1_inhibitor activity, induced; protein conformation 11517233; 18073109 29 0 0 +JAK3 JAK3 EC 2.7.10.2; KINASE; Kinase, protein; Protein kinase, TK; Protein kinase, tyrosine (non-receptor) P52333 3718 19p13.11 human Y980-p 447636 LLPLDKDyYVVREPG PK_Tyr_Ser-Thr enzymatic activity, induced 9391116 9 4 2 +DCTN6 dynactin 6 Motility/polarity/chemotaxis O00399 10671 8p12 human T186-p 27933603 KTMKGSStPVKN___ molecular association, regulation; intracellular localization cell cycle regulation PLK1(INDUCES) 23455152 1 0 0 Dynactin 6 targets PLK1 to mitotic kinetochores. +Cebpa C/EBP-alpha DNA-binding; Transcription factor P05554 24252 1q21 rat K326-ac 56394106 SDNDRLRkRVEQLSR bZIP_2 molecular association, regulation autophagy, induced beclin 1(INDUCES) 34217716 2 0 0 +Myc Myc DNA-binding; Nucleolus; Oncoprotein; Transcription factor P01108 17869 15 D1|15 26.19 cM mouse K338-ac 458888 RKDYPAAkRAKLDSG Myc_N activity, induced; protein stabilization cell growth, induced; cell differentiation, induced; transcription, induced 15572685; 26655722 7 4 5 +IRS2 IRS2 Adaptor/scaffold; Motility/polarity/chemotaxis Q9Y4H2 8660 13q34 human S391-p 1984215 SVAGSPLsPGPVRAP activity, inhibited 34731634 3 39 80 +FOXO1 FOXO1A DNA-binding; Nuclear receptor co-regulator; Oncoprotein; Transcription factor Q12778 2308 13q14.11 human K222-ac 15625101 HNLSLHSkFIRVQNE Forkhead intracellular localization; phosphorylation 20519497 1 0 1 +EYA3 EYA3 EC 3.1.3.48; PHOSPHATASE; Protein phosphatase, tyrosine (non-receptor) Q99504 2140 1p35.3 human Y237-p 1870640400 TTLAATTyQSEKPSV cell growth, altered 31847183 1 0 0 +Irs1 IRS1 Adaptor/scaffold; Motility/polarity/chemotaxis P35570 25467 9q34 rat Y1222-p 448699 SSEDLSTyASINFQK molecular association, regulation SHP-2(INDUCES) 7588273 2 2 0 +Slc14a2 SLC14A2 Membrane protein, integral; Membrane protein, multi-pass; Transporter; Transporter, SLC family Q62668 54302 18q12.3 rat S486-p 2813501 TVFPRRKsVFHIEWS activity, induced; molecular association, regulation; intracellular localization SNAPIN(INDUCES) 18495802; 20071460; 20457831; 22205230; 25377918 10 2 3 apical plasma membrane accumulation +KCNQ2 Kv7.2 Channel, potassium; Membrane protein, integral; Membrane protein, multi-pass O43526 3785 20q13.33 human S52-p 12526300 SEAPKRGsILSKPRA activity, induced 9872318 2 4 2 +Fmr1 FMR1 Nucleolus; RNA-binding; Translation P35922 14265 X A7.1|X 34.83 cM mouse R543-me 4046000 GGRGQGGrGRGGGFK FXMRP1_C_core molecular association, regulation RNA(DISRUPTS) 20064924 4 0 0 methylation inhibits sc1 RNA binding; R533 and R538 determine association with polyribosomes; methylation doesnot inhibit AATYK mRNA association; different RNAs have distinct molecular requirements for binding to FMR1 +GATA4 GATA4 Motility/polarity/chemotaxis; Transcription factor P43694 2626 8p23.1 human K329-ac 1877203101 PKNLNKSkTPAAPSG apoptosis, inhibited; transcription, induced 32239217 1 0 0 +EP300 p300 ACETYLTRANSFERASE; Acetyltransferase; EC 2.3.1.48; Motility/polarity/chemotaxis; Nuclear receptor co-regulator; Transcription, coactivator/corepressor Q09472 2033 22q13.2 human S2366-p 486264 MEQGHFAsPDQNSML molecular association, regulation; enzymatic activity, induced transcription, altered SP1(NOT_REPORTED) 17623675 2 0 0 controls EGF-induced keratin 16 promoter activity ; regulates HAT activity of p300 +OSBP OSBP Lipid-binding P16258 rabbit S192-p 452647 AVKMLAEsDESGDEE molecular association, regulation; intracellular localization VAPA(INDUCES) 22875984 1 73 12 regulation of Sphingomyelin synthesis. S381A/S3D mutant has enhanced binding and altered localization +POLH POLH DNA repair, damage; EC 2.7.7.7; Transferase Q9Y253 5429 6p21.1 human K311-sm 1877365917 GIEHDPVkPRQLPKT intracellular localization; enzymatic activity, inhibited 32350109 1 1 0 +TELO2 TELO2 Adaptor/scaffold Q9Y4R8 9894 16p13.3 human S485-p 27530803 PQAQLAGsDSDLDSD protein degradation; molecular association, regulation; ubiquitination; intracellular localization signaling pathway regulation FBXO9(INDUCES) 23263282 1 1 0 mediates mTORC1 signaling +SMAD4 SMAD4 DNA-binding; Nuclear receptor co-regulator; Transcription, coactivator/corepressor Q13485 4089 18q21.2 human K507-ub 18898600 ILRMSFVkGWGPDYP MH2 molecular association, regulation transcription, induced; signaling pathway regulation SMAD3(INDUCES) 12794086 1 1 0 ubiquitin-assisted oligomerization with Smad3; regulation of TGF-beta signaling +SCN5A SCN5A Channel, sodium; Membrane protein, integral; Membrane protein, multi-pass Q14524 6331 3p22.2 human T101-p 1867858201 IVLNKGKtIFRFSAT protein degradation; molecular association, regulation endocytosis, altered; autophagy, induced LC3B(INDUCES) 30759345 1 0 0 +CCND3 CCND3 Activator; Cell cycle regulation; Nuclear receptor co-regulator P30281 896 6p21.1 human T283-p 452160 QGPSQTStPTDVTAI protein degradation; molecular association, regulation; ubiquitination; intracellular localization; phosphorylation cell cycle regulation; carcinogenesis, inhibited; carcinogenesis, altered; apoptosis, induced; cell growth, inhibited FBXL8(INDUCES) 15252116; 15326477; 16331257; 22885699; 33122824; 34103301 8 4 5 increases Rb phosphorylation in tissues from CCND3 wt and CCND3 T283A AML patients +AKT1 Akt1 EC 2.7.11.1; KINASE; Kinase, protein; Oncoprotein; Protein kinase, AGC; Protein kinase, Ser/Thr (non-receptor) P31749 207 14q32.33 human S246-p 460649 LSRERVFsEDRARFY Pkinase enzymatic activity, induced apoptosis, inhibited 16549426 1 0 0 doxorubicin-induced apoptosis +SOX2 SOX2 Cell development/differentiation; DNA-binding; Transcription factor P48431 6657 3q26.33 human K245-sm 12004415 GSMGSVVkSEASSSP transcription, inhibited 23515309 3 0 0 +Mef2c MEF2C DNA-binding; Transcription factor Q8CFN5 17260 13 C3|13 43.68 cM mouse S396-p 456980 SIKSEPVsPPRDRTT molecular association, regulation PIN1(INDUCES) 20801874 3 9 0 Pin1 binding decreases MEF2C stability and its transcriptional activity +Etv4 ETV4 DNA-binding P28322 18612 11 D|11 65.48 cM mouse K6-ac 26373304 __MERRMkGGYLDQR ETS_PEA3_N sumoylation transcription, induced 21543453 1 1 0 acetylated sites inhibits sumoylation reciprocally +PPP1R12A MYPT1 Motility/polarity/chemotaxis; PHOSPHATASE; Protein phosphatase, regulatory subunit O14974 4659 12q21.2-q21.31 human T853-p 452075 PREKRRStGVSFWTQ enzymatic activity, inhibited; phosphorylation cell motility, induced; cell growth, inhibited; cell differentiation, induced; cell adhesion, induced; cytoskeletal reorganization; signaling pathway regulation 31834925; 33802280; 35594862; 37064875 44 2 17 +CD37 CD37 Membrane protein, integral; Membrane protein, multi-pass P11049 951 19q13.33 human Y274-p 7788473 CRNLDHVyNRLARYR apoptosis, inhibited; signaling pathway regulation 22624718 1 2 22 +TBXA2R TXA2-R iso2 GPCR, family 1; Membrane protein, integral; Membrane protein, multi-pass; Receptor, GPCR P21731-2 6915 19p13.3 human S357-p 469629 RLPGSSDsRASASRA molecular association, regulation; receptor desensitization, altered; receptor internalization, altered ARRB2(INDUCES) 16956790 1 0 0 +FBXL19 FBXL19 UBIQUITIN LIGASE; Ubiquitin ligase Q6PCT2 54620 16p11.2 human K240-ub 1881559701 GRERHLKkVGGDACL protein degradation cell motility, induced 33053230 1 0 0 increasing Rac1 stability +VCL Vinculin iso2 Cell adhesion; Cytoskeletal; Motility/polarity/chemotaxis P18206-2 7414 10q22.2 human Y100-p 454004 QMLQSDPySVPARDY Vinculin molecular association, regulation cytoskeletal reorganization; cell adhesion, altered BSG(INDUCES) 25033086 4 3 53 +IGF1R IGF1R EC 2.7.10.1; KINASE; Kinase, protein; Membrane protein, integral; Protein kinase, TK; Protein kinase, tyrosine (receptor) P08069 3480 15q26.3 human S1321-p 25240303 LPLPDRHsGHKAENG receptor internalization, induced; protein degradation; molecular association, regulation; phosphorylation signaling pathway regulation ARRB1(INDUCES) 22509025 1 0 0 S1278 induces transient association, while S1321 induces more stable association; Akt phosphorylation, regulates ERK/Akt signaling pathway +MTOR mTOR Autophagy; EC 2.7.11.1; KINASE; Kinase, protein; Motility/polarity/chemotaxis; Protein kinase, Ser/Thr (non-receptor); Protein kinase, atypical P42345 2475 1p36.22 human T2164-p 20473600 APSLQVItSKQRPRK molecular association, regulation; phosphorylation cell cycle regulation; cell growth, induced; signaling pathway regulation Raptor(DISRUPTS) 21576368 1 1 0 phosphorylation increases the sensitivity and duration of insulin-stimulated mTORC1 signaling; Increased phosphorylation of itself at S2481 and of S6K1 and 4EBP1 +Pdgfrb PDGFRB EC 2.7.10.1; KINASE; Kinase, protein; Membrane protein, integral; Oncoprotein; Protein kinase, TK; Protein kinase, tyrosine (receptor) Q05030 rat Y750-p 447508 SKDESVDyVPMLDMK PK_Tyr_Ser-Thr molecular association, regulation; enzymatic activity, induced cell cycle regulation; cell growth, induced; signaling pathway regulation NCK1(INDUCES) 23181695; 23776396 26 4 6 downstream signaling pathway phosphorylation of STAT3, ERK1/2, Akt, and PLCG1 was determined in PDGF-stimulated VSMCs +PDHA1 PDHA1 Amino Acid Metabolism - valine, leucine and isoleucine biosynthesis; Carbohydrate Metabolism - butanoate; Carbohydrate Metabolism - citrate (TCA) cycle; Carbohydrate Metabolism - glycolysis and gluconeogenesis; Carbohydrate Metabolism - pyruvate; EC 1.2.4.1; Mitochondrial; Oxidoreductase P08559 5160 Xp22.12 human Y289-p 454752 MELQTYRyHGHSMSD E1_dh enzymatic activity, inhibited carcinogenesis, induced 26848621 1 28 437 essential for Src?s metabolic and pro-malignant effects +BRCA1 BRCA1 EC 6.3.2.-; Nuclear receptor co-regulator; Transcription, coactivator/corepressor; Tumor suppressor; UBIQUITIN LIGASE; Ubiquitin conjugating system; Ubiquitin ligase P38398 672 17q21.31 human S1189-p 450007 QKGELSRsPSPFTHT molecular association, regulation; intracellular localization cell growth, induced ATM(INDUCES) 10550055; 19683496; 21706030 6 15 6 +MYC Myc DNA-binding; Nucleolus; Oncoprotein; Transcription factor P01106 4609 8q24.21 human S82-p 4967400 PLSPSRRsGLCSPSY Myc_N protein degradation; protein stabilization; ubiquitination; phosphorylation cell growth, induced; apoptosis, inhibited; transcription, induced; transcription, inhibited 22025562; 33461590; 36513627 4 6 1 +VCP VCP Chaperone; DNA repair, damage; EC 3.6.4.6; Endoplasmic reticulum; Hydrolase P55072 7415 9p13.3 human S748-p 457558 RFARRSVsDNDIRKY Vps4_C apoptosis, inhibited 16551632 2 9 1 +Nphs1 NPHS1 Cell adhesion; Immunoglobulin superfamily; Membrane protein, integral Q9R044 64563 1q21 rat Y1204-p 469565 PGAWGPLyDEVRMDP molecular association, regulation; phosphorylation cytoskeletal reorganization NCK1(NOT_REPORTED); PLCE1(INDUCES) 16934223; 18256598; 19179337; 22013520 16 1 0 +Hipk2 HIPK2 EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, CMGC; Protein kinase, Ser/Thr (non-receptor) Q9QZR5 15258 6|6 B1 mouse Y361-p 449571 SKAVCSTyLQSRYYR Pkinase intracellular localization; phosphorylation 23485397 6 78 3324 induces phosphorylation of HIPK2 substrates, inhibits HIPK2 aggresome accumulation +STMN2 STMN2 Cytoskeletal Q93045 11075 8q21.13 human S50-p 455606 KQINKRAsGQAFELI Stathmin carcinogenesis, induced; cell motility, induced; cytoskeletal reorganization 23893240 5 5 0 +SNAI1 Snail1 C2H2-type zinc finger protein; Transcription factor O95863 6615 20q13.13 human S107-p 455882 SQPPSPPsPAPSSFS protein degradation; protein stabilization; molecular association, regulation; phosphorylation; enzymatic activity, induced; activity, induced; ubiquitination; intracellular localization carcinogenesis, induced; cell motility, induced; cell motility, altered; transcription, induced; signaling pathway regulation; transcription, altered GSK3B(DISRUPTS) 15448698; 15647282; 19004823; 19923321; 20305697; 31209060 6 1 0 EGF signaling pathway; inhibits degradation of protein by supressing ubiquitination and inhibits the phosphorylation of S104 +Cyp1a1 CYP1A1 Amino Acid Metabolism - tryptophan; Cofactor and Vitamin Metabolism - retinol; EC 1.14.14.1; Oxidoreductase; Xenobiotic Metabolism - metabolism by cytochrome P450 P00184 13076 9 B|9 31.34 cM mouse T35-p 471065 WVVRATRtWVPKGLK intracellular localization 16899466 1 0 0 regulates CYP1A1 mitochondrial trafficking +Cebpb C/EBP-beta DNA-binding; Motility/polarity/chemotaxis; Transcription factor P21272 24253 3q42 rat S64-p 456166 HERAIDFsPYLEPLA transcription, induced; cell growth, altered 15314150; 17433708 8 0 1 +Ikbkb IKKB EC 2.7.11.10; KINASE; Kinase, protein; Protein kinase, Other; Protein kinase, Ser/Thr (non-receptor) O88351 16150 8|8 A2 mouse S697-p 17934903 QPSSACDsLPESDKK molecular association, regulation; phosphorylation PPP2R3C(INDUCES) 20925653 1 5 0 interaction with PPP2R3C (aka G4-1) downregulates IKK-beta activity; S181 phosphorylation increased in S679/682/689/692/697/701/705A mutant +ACSS1 ACSS1 Carbohydrate Metabolism - glycolysis and gluconeogenesis; Carbohydrate Metabolism - propanoate; Carbohydrate Metabolism - pyruvate; EC 6.2.1.1; Ligase; Mitochondrial Q9NUB1 84532 20p11.21 human K642-ac 464663 LPKTRSGkVMRRLLR AMP-binding_C enzymatic activity, inhibited 16788062 2 2 0 +STK26 MST4 EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, STE; Protein kinase, Ser/Thr (non-receptor) Q9P289 51765 Xq26.2 human T328-p 22781373 HPEWSFTtVRKKPDP molecular association, regulation carcinogenesis, induced; cell motility, induced MOB1A(INDUCES) 30072378 1 3 10 +CTNNB1 CTNNB1 Actin-binding; Cell adhesion; Motility/polarity/chemotaxis; Nuclear receptor co-regulator; Oncoprotein; Transcription factor P35222 1499 3p22.1 human K19-ub 486323 MAMEPDRkAAVSHWQ protein degradation carcinogenesis, inhibited; cell growth, inhibited; transcription, inhibited 16849322 1 5 0 K19 is primary site of ubquitination ; when both sites are mutated induces TCF transcription and transformation +Gata1 GATA1 DNA-binding; Transcription factor P17679 14460 X A1.1|X 3.59 cM mouse K316-ac 466359 ASGKGKKkRGSNLAG protein degradation; acetylation; ubiquitination; phosphorylation DNA(INDUCES) 16858405 2 0 0 Phosphorylation and acetylation cause the degradation of acetylated GATA-1; acetylation of GATA-1 causes ubiquitination; DNA binding is required for MAPK-dependent phosphorylation +WWC1 KIBRA Adaptor/scaffold Q8IX03 23286 5q34 human T929-p 3205626 STIIRSKtFSPGPQS cell motility, induced; cell growth, induced 24269383 1 11 4 +Clip1 Restin Cytoskeletal Q9JK25 65201 12q16 rat S1246-p 3189736 EDPNSYDsDDQEKQS molecular association, regulation dynactin 1(INDUCES) 20664522 3 17 0 +DROSHA DROSHA EC 3.1.26.3; Nucleolus; RNA processing; RNA-binding; Ribonuclease Q9NRR4 29102 5p13.3 human S300-p 14572630 RHRDNRRsPSLERSY molecular association, regulation; intracellular localization DGCR8(DISRUPTS) 20554852; 21674040; 25699712 3 15 0 +Adcy6 ADCY6 Adenylyl cyclase; EC 4.6.1.1; Lyase; Membrane protein, integral; Membrane protein, multi-pass; Nucleotide Metabolism - purine; Transporter; Transporter, aquaporin family AAA40678 25289 7q36 rat S568-p 455528 TFLILGAsQKRKEEK enzymatic activity, inhibited 11877398 1 0 0 +RHOA RHOA G protein; G protein, monomeric; G protein, monomeric, Rho; Motility/polarity/chemotaxis; Oncoprotein P61586 387 3p21.31 human Y34-p 473955 KDQFPEVyVPTVFEN Ras molecular association, regulation; activity, inhibited cytoskeletal reorganization; signaling pathway regulation PKN1(DISRUPTS); PKN2(DISRUPTS); Diaphanous-1(DISRUPTS); RTKN(DISRUPTS); ROCK2(DISRUPTS); DAAM1(DISRUPTS); ROCK1(DISRUPTS) 23027962 1 2 14 phosphorylation of this site inhibits binding of RhoA to cellular effectors; phosphorylation of this site inhibits F-actin formation +SREBF1 SREBP-1 DNA-binding; Membrane protein, integral; Membrane protein, multi-pass; Transcription factor P36956 6720 17p11.2 human S117-p 469986 YPSMPAFsPGPGIKE sumoylation transcription, induced; transcription, altered 10915800; 18403372; 20863500; 22384276 5 6 0 +MUC17 MUC17 Cell adhesion; Membrane protein, integral; Motility/polarity/chemotaxis Q685J3 140453 7q22.1 human S4492-p 1869193201 RPQVMTTsF______ intracellular localization 31387973 1 1 0 +DNM1L DRP1 Apoptosis; EC 3.6.5.5; Endoplasmic reticulum; Hydrolase; Microtubule-binding; Mitochondrial; Motor O00429 10059 12p11.21 human K568-sm 9859924 QDSRRETkNVASGGG activity, induced; intracellular localization 19638400 1 0 0 sumoylation is linked to its GTPase activity cycle, and influenced by DRP1 localization +SENP3 SENP3 DESUMOYLASE; EC 3.4.22.68; Nucleolus; Protease; Sumo-specific protease Q9H4L4 26168 17p13.1 human S141-p 36438201 RMLLYSKsTSLTFHW molecular association, regulation; intracellular localization NPM1(INDUCES) 25288641 1 1 0 ribosome biogenesis-28S rRNA maturation +PHF8 PHF8 DEMETHYLASE; Demethylase; EC 1.14.11.27; Nucleolus Q9UPP1 23133 Xp11.22 human S880-p 3216126 NSDDAPWsPKARVTP molecular association, regulation; methylation cell cycle regulation; transcription, induced DNA(INDUCES) 25548279 1 34 2 CDK2 phosphorylation of PHF8 enhances H3k9me2 demethylation +FANCD2 FANCD2 DNA repair, damage Q9BXW9 2177 3p25.3 human S1257-p 3925205 EPGTAADsQQIHEEK FancD2 activity, induced; molecular association, regulation; ubiquitination; intracellular localization signaling pathway regulation DNA(INDUCES) 37392383 1 7 0 regulates the FA pathway +Brsk2 BRSK2 EC 2.7.11.1; EC 2.7.11.26; KINASE; Kinase, protein; Protein kinase, CAMK; Protein kinase, Ser/Thr (non-receptor) Q69Z98 75770 7|7 F5 mouse T448-p 4734891 PLPTPKGtPVHTPKE protein stabilization; enzymatic activity, inhibited; phosphorylation 23790753 1 1 0 inhibits axon branching (activated in BRSK2 18A mutant) +PRKD2 PRKD2 EC 2.7.11.13; KINASE; Kinase, protein; Motility/polarity/chemotaxis; Protein kinase, CAMK; Protein kinase, Ser/Thr (non-receptor) Q9BZL6 25865 19q13.32 human S710-p 449865 GEKSFRRsVVGTPAY Pkinase molecular association, regulation; enzymatic activity, induced transcription, induced; signaling pathway regulation 14-3-3 eta(INDUCES); Exportin-1(DISRUPTS); 14-3-3 eta(DISRUPTS) 12058027; 17962809 5 28 63 +IKBKG IKKG Adaptor/scaffold; Protein kinase, regulatory subunit Q9Y6K9 8517 Xq28 human S85-p 458399 ELLHFQAsQREEKEF NEMO molecular association, regulation; ubiquitination; intracellular localization; phosphorylation transcription, induced; transcription, altered ATM(INDUCES) 16497931; 18583959; 21811235 5 0 0 +CA9 CA9 EC 4.2.1.1; Energy Metabolism - nitrogen; Lyase; Membrane protein, integral; Nucleolus Q16790 768 9p13.3 human T443-p 21691604 RRQHRRGtKGGVSYR molecular association, regulation; enzymatic activity, induced cell motility, induced MMP14(INDUCES) 22037869; 28692057 2 0 0 +CDC20 CDC20 Cell cycle regulation; Ubiquitin conjugating system Q12834 991 1p34.2 human S92-p 454660 AAQMEVAsFLLSKEN molecular association, regulation cell cycle regulation UBE2S(DISRUPTS) 26811472 2 4 0 phosphorylation-dependent regulation of Ube2S is coordinated with the microtubule-binding status of kinetochores +Src Src EC 2.7.10.2; KINASE; Kinase, protein; Oncoprotein; Protein kinase, TK; Protein kinase, tyrosine (non-receptor) Q9WUD9 83805 3q42 rat Y419-p 448234 RLIEDNEyTARQGAK PK_Tyr_Ser-Thr activity, induced; molecular association, regulation; phosphorylation; enzymatic activity, induced translation, altered; cell growth, induced; cytoskeletal reorganization; cell adhesion, altered; signaling pathway regulation ITGB3(INDUCES); ILK(INDUCES); caveolin-1(INDUCES) 14630916; 18252715; 18559349; 20676131; 21445358; 24611720; 25371038; 25672415; 34194565; 34830154; 36034878 447 103 3046 induces ERK signaling +TBK1 TBK1 EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, Other; Protein kinase, Ser/Thr (non-receptor) Q9UHD2 29110 12q14.2 human Y179-p 23151249 SLYGTEEyLHPDMYE Pkinase molecular association, regulation; phosphorylation signaling pathway regulation Other(INDUCES) 28049762; 36640307 3 1 4 induces binding to P protein of RABV thus inhibiting the interferon induction pathways; phosphorylation at the priming site induces autophosphorylation at S172. Production of type 1 IFN induced. Phosphorylation and activation of IRF3 induced +CD226 DNAM-1 Cell adhesion; Immunoglobulin superfamily; Membrane protein, integral Q15762 10666 18q22.2 human S329-p 450987 YVNYPTFsRRPKTRV activity, induced; molecular association, regulation ITGAL(INDUCES) 10591186; 15684041; 9712030 4 0 0 S329 phosphorylation is critical for DNAM-1 adhesion.; Wild type, but not S329 mutant, DNAM-1 associated with lipid rafts in the forming immunological synapse. +LRP5 LRP5 Membrane protein, integral; Receptor, misc. O75197 4041 11q13.2 human S1503-p 15411894 PILNPPPsPATDPSL enzymatic activity, induced 34205318 1 0 1 regulates HIF1A stability by inducing hydroxylation activity of PHD2 +DAP3 DAP3 Apoptosis; Mitochondrial; Nuclear receptor co-regulator P51398 7818 1q22 human S252-p 2226200 KELKRQSsLGMFHLL DAP3 apoptosis, induced 18227431 1 1 0 +FOXM1 FOXM1 DNA-binding; Transcription factor Q08050 2305 12p13.33 human K218-sm 31898504 HLEQRQVkVEEPSRP protein degradation; ubiquitination; intracellular localization cell cycle regulation; cell growth, inhibited; transcription, inhibited 24362530 2 0 0 +FOXO3 FOXO3A Autophagy; DNA-binding; Oncoprotein; Transcription factor O43524 2309 6q21 human K242-ac 460593 IINPDGGkSGKAPRR Forkhead activity, induced; protein stabilization; molecular association, regulation; ubiquitination; intracellular localization; phosphorylation apoptosis, induced; transcription, induced JNK1(INDUCES); SKP2(DISRUPTS) 21841822; 26376801; 27669435 5 0 0 +DCX Doublecortin Cytoskeletal; Motility/polarity/chemotaxis O43602 1641 Xq23 human S47-p 451112 TRTLQALsNEKKAKK molecular association, regulation; intracellular localization cytoskeletal reorganization TUBA1B(DISRUPTS); ACTA1(INDUCES) 15632197; 32050972 5 0 0 +HIF1A HIF1A Autophagy; DNA-binding; Transcription factor Q16665 3091 14q23.2 human S657-p 17331802 ETTSATSsPYRDTQS protein degradation 20889502 1 2 0 +ZWINT ZWINT Cell cycle regulation O95229 11130 10q21.1 human S250-p 20765004 PTRPQEQsTGDTMGR Zwint molecular association, regulation; intracellular localization; phosphorylation cell cycle regulation ZW10(INDUCES) 21775627 1 1 0 inhibits phosphorylation of dynein and induces its recruitment with ZW10 to kinetochores, +PARP1 PARP1 DNA repair, damage; EC 2.4.2.30; Nuclear envelope; Nuclear receptor co-regulator; Nucleolus; Transferase P09874 142 1q42.12 human T373-p 463805 AATPPPStASAPAAV enzymatic activity, induced transcription, induced 16627622; 23597856 2 1 0 +CDC42BPA MRCKA EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, AGC; Protein kinase, Ser/Thr (non-receptor) Q5VT25 8476 1q42.13 human T240-p 12612501 QSSVAVGtPDYISPE Pkinase enzymatic activity, induced cytoskeletal reorganization 11283256 1 0 0 +KDM5B JARID1B Cancer Testis Antigen (CTA); DEMETHYLASE; Demethylase; EC 1.14.11.-; Oxidoreductase; Transcription, coactivator/corepressor Q9UGL1 10765 1q32.1 human S1456-p 15404114 FKLERERsYELVRSA molecular association, regulation cell cycle regulation; carcinogenesis, induced; transcription, induced DNA(DISRUPTS) 31776402 1 6 3 induces mammosphere formation in cancer cells +RB1 Rb Nuclear receptor co-regulator; Oncoprotein; Transcription, coactivator/corepressor; Tumor suppressor P06400 5925 13q14.2 human K873-ac 459026 SNPPKPLkKLRFDIE Rb_C molecular association, regulation; intracellular localization; phosphorylation cell cycle regulation; cell differentiation, induced; transcription, induced E2F1(DISRUPTS); MDM2(INDUCES) 11433299; 15044952; 16374512 4 0 0 +TRPM8 TRPM8 Channel, cation; Membrane protein, integral; Membrane protein, multi-pass Q7Z2W7 79054 2q37.1 human S1040-p 34360655 CKEKNMEsSVCCFKN receptor desensitization, inhibited 32290846 1 0 1 +Vangl2 VANGL2 Adaptor/scaffold; Membrane protein, integral; Membrane protein, multi-pass Q91ZD4 93840 1 H3|1 79.54 cM mouse S84-p 18460401 GTSEHSIsHDDLTRI Strabismus activity, induced; protein stabilization 21316585 1 0 0 +Wasf1 WAVE1 Cytoskeletal; Motility/polarity/chemotaxis Q8R5H6 83767 10 B1|10 22.07 cM mouse S310-p 4764996 LIENRPQsPAAGRTP activity, inhibited 20403076 4 8 0 +H2AZ2 H2AFV Q71UI9 94239 7p13 human K4-ub 52485007 ____AGGkAGKDSGK Histone protein degradation 26676607 0 1 0 +CDKN1B p27Kip1 Cell cycle regulation; Inhibitor; Oncoprotein; Protein kinase, regulatory subunit P46527 1027 12p13.1 human T187-p 447875 NAGSVEQtPKKPGLR protein degradation; protein stabilization; molecular association, regulation; ubiquitination; protein conformation cell cycle regulation; carcinogenesis, induced; cell growth, induced CCND1(INDUCES); CDK2(DISRUPTS); CKS1(INDUCES); CUL1(INDUCES); CDK4(INDUCES); PIN1(INDUCES); SKP2(INDUCES); SKP1A(INDUCES) 10375532; 10781063; 10931950; 11726503; 12140288; 12700233; 16880511; 17053782; 17254966; 17409098; 18710949; 19204084; 19584057; 24336329; 27140628; 30976006; 33574916; 34407842 54 1 1 +Pam PAM EC 1.14.17.3; EC 4.3.2.5; Lyase; Membrane protein, integral; Oxidoreductase; Vesicle P14925 25508 9q37 rat S937-p 450813 FASRKGYsRKGFDRV protein stabilization; intracellular localization 10409666 1 0 0 Phosphorylation of PAM-1 at S937 directs newly synthesized and internalized protein away from lysosomes +SNCA SNCA Adaptor/scaffold P37840 6622 4q22.1 human T81-gl 1498941801 VTAVAQKtVEGAGSI Synuclein protein stabilization 30651314 0 1 0 inhibits the aggregation of alpha-synuclein but can also alter the structure of a-synuclein aggregates in site specific ways, inhibit a-Synuclein toxicity +Hcn4 HCN4 Channel, cation; Membrane protein, integral; Membrane protein, multi-pass O70507 330953 9|9 B mouse S1139-p 15103400 VTLPRKTsSGSLPPP activity, induced 20713547 1 0 0 required for PKA to shift the voltage dependence of HCN4 +IL4R IL4R Membrane protein, integral; Receptor, cytokine P24394 3566 16p12.1 human Y575-p 57775900 VSAPTSGyQEFVHAV molecular association, regulation GRB2(INDUCES) 27479084 1 0 0 Y575 and Arg576 (pY575R576) +CEBPB C/EBP-beta DNA-binding; Motility/polarity/chemotaxis; Transcription factor Q05826 chicken K39-me 1868113506 DCLAALNkLHPRAAG transcription, altered 18647749 1 0 0 +Irs1 IRS1 Adaptor/scaffold; Motility/polarity/chemotaxis P35569 16367 1 C5|1 42.0 cM mouse S632-p 447506 NGDYMPMsPKSVSAP protein degradation; molecular association, regulation neural plasticity; signaling pathway regulation PIK3C2A(DISRUPTS) 10092613; 23142081; 32075735; 34234788 41 26 1 +SCNN1A ENaC-alpha Channel, sodium; Membrane protein, integral; Membrane protein, multi-pass; Transporter, ion channel P37088 6337 12p13.31 human T663-p 456847 SAGASSStCPLGGP_ intracellular localization 17596527 1 1 0 +Camk2a CAMK2A EC 2.7.11.17; KINASE; Kinase, protein; Protein kinase, CAMK; Protein kinase, Ser/Thr (non-receptor) P11275 25400 18q12.1 rat T253-p 451571 DLINKMLtINPSKRI Pkinase intracellular localization cell cycle regulation; cell growth, inhibited; apoptosis, induced 16805815; 24407174 8 5 1 +CARD11 CARD11 Adaptor/scaffold Q9BXL7 84433 7p22.2 human S558-p 4737145 MQPPRSRsSIMSITA activity, induced 19706536 2 0 0 important for HPK1-mediated and TCR-mediated activation of NFkB-p65 +CCKBR CCKBR GPCR, family 1; Membrane protein, integral; Membrane protein, multi-pass; Receptor, GPCR P32239 887 11p15.4 human T439-p 6057804 SLSRLSYtTISTLGP molecular association, regulation ARRB1(INDUCES); RGS2(INDUCES) 19064631; 21156802 2 0 0 +LRRK1 LRRK1 EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, Ser/Thr (non-receptor); Protein kinase, TKL Q38SD2 79705 15q26.3 human T1075-p 1879806800 NQRNRCStFRVKRNQ phosphorylation; enzymatic activity, induced 36040231 1 1 0 induces Rab7 phosphorylation +ARHGAP22 ARHGAP22 GAP; GAP, Rac/Rho Q7Z5H3 58504 10q11.22-q11.23 human S16-p 22262003 ARRARSKsLVMGEQS molecular association, regulation cell motility, induced 14-3-3 beta(INDUCES) 21969604 1 8 0 +Grb10 GRB10 Adaptor/scaffold Q60760 14783 11 A1|11 7.15 cM mouse S501-p 4727990 TRMNILSsQSPLHPS molecular association, regulation; protein stabilization cell growth, inhibited; transcription, induced; signaling pathway regulation INSR(DISRUPTS); Raptor(INDUCES) 21659605; 24746805; 26000738 4 6 2 reduced soft agar colony formation ; thermogenic and lipolytic gene expression induced +Ripk1 RIPK1 EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, Ser/Thr (non-receptor); Protein kinase, TKL Q60855 19766 13 A3.3|13 14.01 cM mouse S321-p 468644 PVLQRMFsLQHDCVP molecular association, regulation; enzymatic activity, inhibited; enzymatic activity, induced apoptosis, inhibited RIPK3(DISRUPTS); CASP8(DISRUPTS); RIPK3(INDUCES); FADD(DISRUPTS) 28506461; 28842570; 28920954; 32366830; 34990405 11 27 34 +HRH1 H1R GPCR, family 1; Membrane protein, integral; Membrane protein, multi-pass; Receptor, GPCR P35367 3269 3p25.3 human T478-p 453403 CNENFKKtFKRILHI receptor desensitization, altered 15107581 1 0 0 +CENPJ CENPJ Cell cycle regulation; Microtubule-binding; Transcription, coactivator/corepressor Q9HC77 55835 13q12.12-q12.13 human S589-p 14918202 EQAADEIsFSSNSSF cell cycle regulation 20531387 1 0 0 required for centriole elongation +Nr5a2 NR5A2 DNA-binding; Nuclear receptor; Transcription factor P45448 26424 1 59.98 cM|1 E4 mouse K289-sm 6124701 HFPSRAIkSEYPDPY protein processing; intracellular localization transcription, inhibited 19125815; 28094767 3 1 0 +PRKAB1 AMPKB1 Autophagy; KINASE; Protein kinase, regulatory subunit Q9Y478 5564 12q24.23 human S108-p 448522 SKLPLTRsHNNFVAI AMPK1_CBM activity, induced; molecular association, regulation; phosphorylation 17728241; 22517326 11 64 2 activates AMPK1 and phosphorylation of T174; S108 mutation abolishes protective effect of salicylate and A-769662 binding, on T172 dephosphorylation. +RAD9A RAD9A Apoptosis; Cell cycle regulation; DNA replication; Deoxyribonuclease; EC 3.1.11.2 Q99638 5883 11q13.2 human S328-p 449812 VLPSISLsPGPQPPK molecular association, regulation; intracellular localization cell cycle regulation; apoptosis, induced; chromatin organization, altered TLK1(INDUCES) 12734188; 18940270; 20305300; 23028682; 26860083 8 11 8 accumulate Rad9 in the cytoplasm; translocated from the nucleus to the mitochondria during etoposide induced-apoptosis (Rad9 mediated apoptosis) +Agtr2 AT2 GPCR, family 1; Membrane protein, integral; Membrane protein, multi-pass; Receptor, GPCR P35351 24182 Xq34 rat S354-p 469106 MSCRKSSsLREMDTF activity, induced cell growth, altered 11040065 1 2 0 +TBC1D3 TBC1D3 GAP; GAP, Rab; Oncoprotein Q8IZP1 729873 17q12 human T165-p 64210901 FFRDRYGtKQRELLH RabGAP-TBC molecular association, regulation Calmodulin(NOT_REPORTED) 28422741 1 0 0 +NFKB1 NFkB-p105 DNA-binding; Transcription factor P19838 4790 4q24 human S903-p 455617 KTTSQAHsLPLSPAS protein stabilization 12871932 1 17 24 +DCX Doublecortin iso2 Cytoskeletal; Motility/polarity/chemotaxis O43602-2 1641 Xq23 human T331-p 469976 SKQSPIStPTSPGSL intracellular localization cell motility, altered; cytoskeletal reorganization 14765123 2 2 2 affects doublecortin localization to growth cones, neurite outgrowth, and neuronal motility +SP1 SP1 C2H2-type zinc finger protein; DNA-binding; Transcription factor P08047 6667 12q13.13 human T723-p 36897201 GVALSVGtLPLDSGA protein stabilization; molecular association, regulation; intracellular localization cell cycle regulation RNF4(DISRUPTS) DNA(DISRUPTS) 25398907 1 0 0 +NFKBIA IkB-alpha DNA-binding; Inhibitor P25963 4792 14q13.2 human Y305-p 448799 FTEDELPyDDCVFGG protein degradation; protein stabilization; intracellular localization; activity, inhibited apoptosis, induced; signaling pathway regulation; transcription, inhibited 12167702; 12909638; 30887112 3 0 5 NF-kB activation in BCR signaling +CEBPA C/EBP-alpha DNA-binding; Transcription factor P49715 1050 19q13.11 human S21-p 448308 PMSSHLQsPPHAPSS activity, induced; molecular association, regulation; protein conformation; activity, inhibited cell differentiation, inhibited; cell differentiation, altered; transcription, inhibited; transcription, altered DNA(DISRUPTS) 14701740; 16446383; 16807249; 20101026; 26515730 10 1 0 +Grin1 NMDAR1 Channel, calcium; Channel, ligand-gated; Membrane protein, integral; Membrane protein, multi-pass P35439 24408 3p13 rat S896-p 448255 SSFKRRRsSKDTSTG molecular association, regulation CAMK2A(DISRUPTS); Calmodulin(DISRUPTS) 36373991; 9252405 24 0 0 +SPTA1 SPTA1 Cytoskeletal; Motility/polarity/chemotaxis P02549 6708 1q23.1 human Y548-p 13421404 KLIGDDHyDSENIKA Spectrin cytoskeletal reorganization 20206558 1 1 0 +TCF3 E2A Cell development/differentiation; DNA-binding; Oncoprotein; Transcription factor P15923 6929 19p13.3 human S359-p 465682 SPSTPVGsPQGLAGT activity, inhibited transcription, inhibited 19801649 2 7 31 +OCLN occludin Cell adhesion; Membrane protein, integral; Membrane protein, multi-pass; Motility/polarity/chemotaxis Q16625 100506658 5q13.2 human T404-p 471472 HYETDYTtGGESCDE molecular association, regulation; intracellular localization occludin(DISRUPTS); ZO2(DISRUPTS) 19114660; 23758859 4 6 5 . Phosphorylation affects occludin solubility and regulates assembly/disassembly of TJ proteins +CYLD CYLD DEUBIQUITINASE; EC 3.4.19.12; Protease; Tumor suppressor; Ubiquitin conjugating system; Ubiquitin-specific protease Q9NQC7 1540 16q12.1 human S441-p 12173908 GHSPLSLsAQSVMEE CYLD_phos_site ubiquitination 15870263 1 0 0 induces ubiquitination of TRAF2 +EGFR EGFR EC 2.7.10.1; KINASE; Kinase, protein; Membrane protein, integral; Oncoprotein; Protein kinase, TK; Protein kinase, tyrosine (receptor) P00533 1956 7p11.2 human S1190-p 451819 PNGIFKGsTAENAEY receptor internalization, altered 7505275 1 1 4 +INCENP INCENP Cell cycle regulation; EC 2.7.11.1 Q9NQS7 3619 11q12.3 human S894-p 450468 RYHKRTSsAVWNSPP activity, induced; protein stabilization; molecular association, regulation; intracellular localization; enzymatic activity, induced cell cycle regulation INCENP(INDUCES) 12925766; 27332895; 27512725; 32028528 10 22 25 abscission during cytokinesis, colocalizes with and required for activation of Aurora B; induces AurB activity +RAF1 RAF1 EC 2.7.11.1; KINASE; Kinase, protein; Oncoprotein; Protein kinase, Ser/Thr (non-receptor); Protein kinase, TKL P04049 5894 3p25.2 human S287-p 9248144 AIRSHSEsASPSALS activity, induced cell cycle regulation 9933647 1 1 2 +CDKN2A p16-INK4A Cell cycle regulation; Nucleolus; Tumor suppressor P42771 1029 9p21.3 human S140-p 448831 AAGGTRGsNHARIDA Ank_2 protein stabilization; molecular association, regulation cell growth, inhibited; apoptosis, induced CDK4(INDUCES) 21270107; 28120917 4 0 0 +RHO Rhodopsin GPCR, family 1; Membrane protein, integral; Membrane protein, multi-pass; Receptor, GPCR P02699 509933 cow S343-p 448680 TVSKTETsQVAPA__ molecular association, regulation; protein conformation SAG(INDUCES) 15041682 5 7 0 Computational and in vitro data. S343 may be a weaker interaction. +Rps6ka3 RSK2 EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, AGC; Protein kinase, Ser/Thr (non-receptor) P18654 110651 X F4|X 73.27 cM mouse S227-p 448063 DHEKKAYsFCGTVEY Pkinase enzymatic activity, induced 10480933; 19956600 14 43 151 +Jun Jun Oncoprotein; Transcription factor P05627 16476 4 C5|4 43.34 cM mouse T91-p 450448 SNGHITTtPTPTQFL Jun molecular association, regulation NPM1(INDUCES); p14ARF(INDUCES) 18316603 8 2 0 +Kdr VEGFR2 EC 2.7.10.1; KINASE; Kinase, protein; Membrane protein, integral; Protein kinase, TK; Protein kinase, tyrosine (receptor) P35918 16542 5 C3.3|5 40.23 cM mouse Y1006-p 455661 TLEHLICySFQVAKG PK_Tyr_Ser-Thr molecular association, regulation cell growth, altered PLCG1(INDUCES) 12598525 1 0 0 +DOK1 DOK1 Adaptor/scaffold; Motility/polarity/chemotaxis Q99704 1796 2p13.1 human Y449-p 448879 KSHNSALySQVQKSG molecular association, regulation CD45(INDUCES); SH2D1A(INDUCES) 10852966; 19481264 3 40 1026 +Eif4ebp1 4E-BP1 Translation; Translation initiation Q60876 13685 8 A2|8 15.95 cM mouse T69-p 447528 RNSPVAKtPPKDLPA eIF_4EBP transcription, induced; translation, induced; signaling pathway regulation 18851840; 34704268 55 57 9 +TCAP Telethonin Motility/polarity/chemotaxis O15273 8557 17q12 human S157-p 448693 GALRRSLsRSMSQEA Telethonin protein degradation; ubiquitination cytoskeletal reorganization 24280220; 32937135 4 5 3 affects synchronous release and removal of Ca2 as a consequence of altered t-tubule organization +ACTA1 ACTA1 Cell development/differentiation; Contractile; Cytoskeletal; Motility/polarity/chemotaxis P68135 rabbit K217-ac 479596 IVRDIKEkLCYVALD Actin activity, inhibited 30962575 1 1 2 CAP/actin inhibitory potency +PIK3CG PIK3CG Autophagy; Carbohydrate Metabolism - inositol phosphate; EC 2.7.1.153; EC 2.7.11.1; KINASE; Kinase, lipid; Motility/polarity/chemotaxis; Protein kinase, Ser/Thr (non-receptor) P48736 5294 7q22.3 human T1024-p 20506703 YLALRHHtNLLIILF PI3_PI4_kinase enzymatic activity, inhibited 21474070 1 0 0 inhibits PIP3 production, enhances B-AR density, improves cardiac function in heart failure +NRK NRK EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, STE; Protein kinase, Ser/Thr (non-receptor) Q7Z2Y5 203447 Xq22.3 human K818-m2 58123000 SLLEQAQkPIDIRQR molecular association, regulation L3MBTL iso4(INDUCES) 23583077 0 1 0 +CTNNA1 CTNNA1 Actin-binding; Motility/polarity/chemotaxis P35221 1495 5q31.2 human S641-p 449139 TPEELDDsDFETEDF Vinculin molecular association, regulation; ubiquitination; intracellular localization; phosphorylation carcinogenesis, induced; carcinogenesis, inhibited; cell growth, inhibited; cell motility, induced; cell motility, inhibited; signaling pathway regulation; transcription, altered; cell growth, induced; cell motility, altered; cytoskeletal reorganization; transcription, inhibited CTNNB1(DISRUPTS); BTRC(DISRUPTS) 19941816; 31432583; 32256776; 34767814 5 98 78 Regulates Wnt and Hh signaling and inhibits cell invasion; inhibits IKB ubiquitination and degradation, inhibits NFkB signaling, regulates p65 phosphorylation and nuclear localization +ZC3HC1 NIPA Cell cycle regulation; Ubiquitin conjugating system Q86WB0 51530 7q32.2 human S354-p 449745 PIVSRTRsWDSSSPV molecular association, regulation cell cycle regulation; apoptosis, altered SKP1A(DISRUPTS) 12748172; 16009132; 17389604 4 41 32 +UHRF1 UHRF1 DNA-binding; EC 6.3.2.-; EC 6.3.2.19; Ligase; Transcription factor; UBIQUITIN LIGASE; Ubiquitin conjugating system; Ubiquitin ligase Q96T88 29128 19p13.3 human S639-p 471011 QQEGGFAsPRTGKGK protein degradation; molecular association, regulation; ubiquitination cell cycle regulation; cell growth, altered USP7(DISRUPTS) 22411829 3 20 1 +Hnrnpa1 hnRNP A1 Nuclear export; RNA splicing; RNA-binding; Spliceosome P04256 29578 7q36 rat S199-p 451555 SQRGRSGsGNFGGGR activity, inhibited 7727389 6 9 8 +MAP2K1 MEK1 EC 2.7.12.2; KINASE; Kinase, protein; Protein kinase, STE; Protein kinase, dual-specificity (non-receptor) P29678 100009316 rabbit S222-p 448513 LIDSMANsFVGTRSY Pkinase enzymatic activity, induced 7873542 117 20 203 in vitro +Plcg2 PLCG2 Carbohydrate Metabolism - inositol phosphate; EC 3.1.4.11; Motility/polarity/chemotaxis; Phospholipase P24135 29337 19q12 rat Y1217-p 447939 LNNQLFLyDTHQNLR enzymatic activity, induced 11507089 19 15 346 +TBK1 TBK1 EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, Other; Protein kinase, Ser/Thr (non-receptor) Q9UHD2 29110 12q14.2 human K30-ub 31033007 VFRGRHKkTGDLFAI Pkinase ubiquitination; intracellular localization; phosphorylation; enzymatic activity, induced transcription, induced; signaling pathway regulation 23453972; 27538435 3 1 0 ubquitination of one of these sites is required for S172 phosphorylation ; TBK1 trans-autophosphorylation phosphorylation at S172, enhances TBK1-induced phosphorylation of IRF3, regulation of downstream-signaling in innate immunity after RNA virus infection +GRN GRN Secreted; Secreted, signal peptide P28799 2896 17q21.31 human S81-p 41198100 IFTVSGTsSCCPFPE Granulin molecular association, regulation TNF-R2(DISRUPTS); TNF-R1(DISRUPTS); TNFRSF25(DISRUPTS) 26005049 1 0 0 +H4c2 H4 DNA-binding P62804 295277 rat K5-ac 458958 ___SGRGkGGKGLGK transcription, induced 19909801 72 22 516 +ZNF746 PARIS C2H2-type zinc finger protein; Transcription regulation Q6NUN9 155061 7q36.1 human S322-p 27533659 QATRFFPsPAQEGAW protein degradation; ubiquitination 28122242 1 2 0 protective effect of DA neuron toxicity +Gja1 GJA1 Channel, misc.; Membrane protein, integral; Membrane protein, multi-pass; Motility/polarity/chemotaxis P23242 14609 10 B4|10 28.64 cM mouse S373-p 459209 RASSRASsRPRPDDL activity, induced; protein degradation; molecular association, regulation; ubiquitination; intracellular localization; phosphorylation endocytosis, induced 14-3-3 theta(INDUCES) 24612377; 26869446; 27281705 19 7 0 internalization, induces phosphorylation at S368 and S255 +Htt Huntingtin Cytoskeletal P42859 15194 5 B2|5 17.92 cM mouse R95-m2 1881211200 NIVAQSLrNSPEFQK methylation; intracellular localization 33852844 1 1 0 Loss of arginine methylation at R118 reduced HTT recruitment to vesicles by 40%, impaired vesicle trafficking and induced neurotoxicity. +FERMT2 kindlin-2 Cytoskeletal; Motility/polarity/chemotaxis Q96AC1 10979 14q22.1 human S175-p 3208608 GPLITPGsGSIYSSP protein degradation; molecular association, regulation; ubiquitination cell cycle regulation; cell growth, induced; apoptosis, inhibited; cytoskeletal reorganization; cell adhesion, inhibited CUL9(INDUCES) 35469017 1 3 0 +MAP3K11 MLK3 EC 2.7.11.25; KINASE; Kinase, protein; Protein kinase, Ser/Thr (non-receptor); Protein kinase, TKL Q16584 4296 11q13.1 human S281-p 448262 WHKTTQMsAAGTYAW PK_Tyr_Ser-Thr molecular association, regulation; enzymatic activity, induced cell differentiation, induced GEFT(INDUCES) 11053428; 18851832; 21965325 8 0 0 +Marcksl1 MLP Cell cycle regulation P28667 17357 4 D2.2|4 63.26 cM mouse S120-p 454291 GGDSSASsPTEEEQE MARCKS protein conformation cytoskeletal reorganization; cell motility, inhibited 22751924 1 13 0 Increases actin stability and regulation of dendritic filopodium generation in neurons +DDAH2 DDAH2 Apoptosis; EC 3.5.3.18; Hydrolase O95865 23564 6p21.33 human S253-p 1872776108 QEALQKLsDVTLVPV intracellular localization; phosphorylation; enzymatic activity, induced signaling pathway regulation 33850055 1 1 0 regulates RLR signaling, regulates DRP1 anf IRF3 phosphorylation +PFKP PFKP Carbohydrate Metabolism - fructose and mannose; Carbohydrate Metabolism - galactose; Carbohydrate Metabolism - glycolysis and gluconeogenesis; Carbohydrate Metabolism - pentose phosphate pathway; EC 2.7.1.11; KINASE; Kinase, other Q01813 5214 10p15.2 human Y64-p 1426260400 VYFIYEGyQGMVDGG PFK molecular association, regulation; intracellular localization; phosphorylation; enzymatic activity, induced carcinogenesis, induced; cell motility, induced; cell growth, induced; transcription, induced; signaling pathway regulation PIK3R1(INDUCES) 29677490; 32195176; 36435833 3 1 0 +CD81 CD81 Membrane protein, integral; Membrane protein, multi-pass P60033 975 11p15.5 human K8-ub 4666602 MGVEGCTkCIKYLLF protein degradation endocytosis, induced 18713730; 31902824 2 0 0 cell surface downregulation of tetraspanins; clathrin-mediated endocytosis, poly-Ub chain binds to Lys8 at the intracellular N-terminal domain, degradation depends on the poly-ubiquitination of K8 +Kcnb1 Kv2.1 Channel, cation; Channel, ligand-gated; Channel, potassium; Membrane protein, integral; Membrane protein, multi-pass P15387 25736 3q42 rat K474-sm 25087004 KNGESIAkKDKVQDN Kv2channel activity, induced 21518833 2 1 0 +Cacna1d CACNA1D Channel, calcium; Membrane protein, integral; Membrane protein, multi-pass P27732 29716 16p16 rat S1743-p 6062700 VNSDRREsLQQTNTT CAC1F_C activity, induced 19074150 2 0 0 +DVL1 DVL1 Inhibitor O14640 1855 1p36.33 human K285-ac 1880010901 IYIGSIMkGGAVAAD intracellular localization transcription, inhibited 31700102 1 1 0 nuclear localization +Slc22a1 SLC22A1 Membrane protein, integral; Membrane protein, multi-pass; Transporter; Transporter, SLC family Q63089 24904 1q11 rat T296-p 455612 WLLSQKRtTRAVRIM Sugar_tr activity, induced 15829703 1 0 0 stimulates ASP+ uptake +SOD1 SOD1 Apoptosis; EC 1.15.1.1; Mitochondrial; Nuclear receptor co-regulator; Oxidoreductase P00441 6647 21q22.11 human K71-ac 466539 HFNPLSRkHGGPKDE Sod_Cu molecular association, regulation; enzymatic activity, inhibited carcinogenesis, inhibited CCS(DISRUPTS); SOD1(DISRUPTS) 26008972 1 1 4 +Cacna1c CACNA1C iso5 Channel, calcium; Membrane protein, integral; Membrane protein, multi-pass Q0PCR6 12288 6 F1|6 55.86 cM mouse S1927-p 455278 ASLGRRAsFHLECLK CAC1F_C activity, induced cell growth, induced 28119464; 28119465 31 3 0 long-term potentiation in response to prolonged theta-tetanus (PTT-LTP); increase channel activity +CHEK2 Chk2 EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, CAMK; Protein kinase, Ser/Thr (non-receptor); Tumor suppressor O96017 11200 22q12.1 human K235-ac 15293829 SGACGEVkLAFERKT Pkinase enzymatic activity, induced cell cycle regulation 30902968; 31209362 2 0 1 +CERT1 COL4A3BP EC 2.7.11.9; KINASE; Kinase, protein; Lipid-binding; Protein kinase, Ser/Thr (non-receptor); Protein kinase, atypical Q9Y5P4 10087 5q13.3 human S141-p 15409121 VSLVSGAsGYSATST molecular association, regulation; activity, inhibited 28652409 0 1 1 reduced PtdIns(4)P binding affinity as well as low ceramide transfer activity, E494R/N495K/P535R/E537K mutations, recovery of both PtdIns(4)P binding and ceramide transfer activity. +RASSF1 RASSF1 iso2 Tumor suppressor Q9NS23-2 11186 3p21.31 human S179-p 13258706 RPVSVPSsKKPPSLQ molecular association, regulation apoptosis, inhibited TRAIL-R1(DISRUPTS); 14-3-3 zeta(INDUCES); 14-3-3 epsilon(INDUCES); TNF-R1(DISRUPTS); MOAP1(DISRUPTS) 20069457 1 0 0 +RXRA RXRA DNA-binding; Motility/polarity/chemotaxis; Nuclear receptor P19793 6256 9q34.2 human S260-p 450891 NMGLNPSsPNDPVTN Hormone_recep molecular association, regulation; protein stabilization; intracellular localization; activity, inhibited carcinogenesis, induced; cell growth, induced; apoptosis, inhibited; signaling pathway regulation; transcription, inhibited; transcription, altered MED1(DISRUPTS); VDR(DISRUPTS); RARB(DISRUPTS); RXRA(DISRUPTS) DNA(DISRUPTS) 10377179; 11826406; 12048211; 16551633; 17900311; 18003614; 20432439; 27852823; 36282921 11 2 0 regulates JNK/RXRa/FGF21 signaling +VCP VCP Chaperone; DNA repair, damage; EC 3.6.4.6; Endoplasmic reticulum; Hydrolase P55072 7415 9p13.3 human Y805-p 449060 EDNDDDLyG______ molecular association, regulation; intracellular localization P130Cas(DISRUPTS) 29743287 6 10 251 enriched localization in focal adhesions +Sik1 SIK EC 2.7.11.1; KINASE; Kinase, protein; Motility/polarity/chemotaxis; Protein kinase, CAMK; Protein kinase, Ser/Thr (non-receptor); Tumor suppressor Q9R1U5 59329 20p12 rat T182-p 456034 KPGEPLStWCGSPPY Pkinase enzymatic activity, induced 32020874 8 0 0 +Map3k5 ASK1 EC 2.7.11.25; KINASE; Kinase, protein; Protein kinase, STE; Protein kinase, Ser/Thr (non-receptor) O35099 26408 10|10 A3 mouse T845-p 448394 GINPCTEtFTGTLQY Pkinase molecular association, regulation; enzymatic activity, induced apoptosis, induced; transcription, induced MKK3(INDUCES) 17210579; 18948261 20 2 1 AP-1 transcriptional activity +GRK2 GRK2 EC 2.7.11.15; KINASE; Kinase, protein; Protein kinase, AGC; Protein kinase, Ser/Thr (non-receptor) P21146 282682 cow S685-p 447726 VPLIQRGsANGL___ molecular association, regulation; intracellular localization ADRB2(INDUCES); DOR-1(INDUCES) 11278469; 28381559 3 11 1 at the plasma membrane +LMNB2 Lamin B2 Cytoskeletal; Motility/polarity/chemotaxis P14732 chicken S411-p 20657001 STSLVRSsRGKRRRI intracellular localization 8449977 1 0 0 nuclear uptake inhibited in vitro +PKP1 plakophilin 1 Cell adhesion; Motility/polarity/chemotaxis Q13835 5317 1q32.1 human S155-p 4712625 QKIKASRsEPDLYCD molecular association, regulation; intracellular localization cell adhesion, inhibited 14-3-3 gamma(INDUCES) 29678907 1 5 99 destabilizing desmosomal adhesion; increased the cytosolic fraction of PKP +TAB1 TAB1 Activator; Motility/polarity/chemotaxis Q15750 10454 22q13.1 human K319-ub 1881312004 MIDTEFAkQTSLDAV signaling pathway regulation 34017102 1 0 0 TRIM26 enhances TLRs-induced NF-kB and MAPK signaling. +FBXO43 FBX43 Unknown function Q4G163 286151 8q22.2 human S334-p 12581001 SISTPEDsGFNSLSL protein degradation; ubiquitination 15753281 1 0 0 +MAPK13 P38D EC 2.7.11.24; KINASE; Kinase, protein; Protein kinase, CMGC; Protein kinase, Ser/Thr (non-receptor) O15264 5603 6p21.31 human T180-p 4787496 RHADAEMtGYVVTRW Pkinase enzymatic activity, induced 10066767; 10201954 4 7 382 +Cdk2 CDK2 Cell cycle regulation; EC 2.7.11.22; KINASE; Kinase, protein; Protein kinase, CMGC; Protein kinase, Ser/Thr (non-receptor) P97377 12566 10|10 D3 mouse T14-p 447738 VEKIGEGtYGVVYKA Pkinase enzymatic activity, inhibited cell cycle regulation; cell differentiation, induced 20462953; 22331465 12 110 1499 regulates centrosome duplication +HDAC5 HDAC5 DEACETYLASE; Deacetylase; EC 3.5.1.98; Hydrolase Q9UQL6 10014 17q21.31 human S498-p 447996 RPLSRTQsSPLPQSP activity, induced; molecular association, regulation; enzymatic activity, inhibited; intracellular localization cell cycle regulation; apoptosis, induced; transcription, induced; transcription, altered; cell differentiation, altered; chromatin organization, altered; cell growth, induced; cell motility, altered HDAC3(DISRUPTS); 14-3-3 epsilon(INDUCES); TBL1X(DISRUPTS); TBL1XR1(DISRUPTS); GPS2(DISRUPTS); 14-3-3 beta(INDUCES); PRKD3(DISRUPTS); SMRT(DISRUPTS); N-CoR1(INDUCES); PRKD1(DISRUPTS); PRKD2(DISRUPTS) 11081517; 18184930; 18332134; 18951085; 21081666; 22243750; 23161540; 24120667; 24207022; 25012661; 28343149; 32485181 24 7 4 +E2F6 E2F6 DNA-binding; Transcription factor O75461 1876 2p25.1 human S52-p 29609300 EDNVQYVsMRKALKV molecular association, regulation transcription, induced DNA(DISRUPTS) 23954429 1 1 0 response to DNA replication stress +Abcc9 ABCC9 Channel, potassium; Membrane protein, integral; Membrane protein, multi-pass; Transporter; Transporter, ABC family P70170 20928 6 G2|6 74.35 cM mouse T633-p 483974 FESCKKHtGVQSKPI activity, induced 15087422 3 1 0 +MAP2K7 MKK7 EC 2.7.12.2; KINASE; Kinase, protein; Protein kinase, STE; Protein kinase, dual-specificity (non-receptor) O14733 5609 19p13.2 human S271-p 447697 ISGRLVDsKAKTRSA Pkinase enzymatic activity, induced transcription, altered 9312068 3 4 0 +ADRB2 ADRB2 GPCR, family 1; Membrane protein, integral; Membrane protein, multi-pass; Receptor, GPCR P07550 154 5q32 human S262-p 447909 GHGLRRSsKFCLKEH 7tm_1 receptor desensitization, inhibited 9461522 15 2 1 like wild type mutant acted in a dominant positive fashion +SREBF1 SREBP-1 DNA-binding; Membrane protein, integral; Membrane protein, multi-pass; Transcription factor P36956 6720 17p11.2 human S430-p 467201 DTLTPPPsDAGSPFQ protein degradation; molecular association, regulation; ubiquitination; phosphorylation transcription, induced FBXW7(INDUCES) 16825193; 19126544; 26759235 3 1 0 +MTOR mTOR Autophagy; EC 2.7.11.1; KINASE; Kinase, protein; Motility/polarity/chemotaxis; Protein kinase, Ser/Thr (non-receptor); Protein kinase, atypical P42345 2475 1p36.22 human S2481-p 447498 TVPESIHsFIGDGLV phosphorylation; enzymatic activity, induced cell cycle regulation; autophagy, inhibited; transcription, altered 10702316; 12807916; 20022946; 21900751; 34604061; 34711683 69 29 1 +Slc17a7 SLC17A7 Membrane protein, integral; Membrane protein, multi-pass; Transporter; Transporter, SLC family; Vesicle Q62634 116638 1q22 rat S519-p 4717544 GHDQLAGsDESEMED molecular association, regulation AP2A2(INDUCES) 25334008 1 1 0 +ITGB1BP1 ICAP1 Cell adhesion; Motility/polarity/chemotaxis O14713 9270 2p25.1 human T38-p 450887 GGLSRSStVASLDTD ICAP-1_inte_bdg activity, inhibited cell adhesion, altered 9813144 1 3 0 A T38D mutation is defective in cell spreading, while a T38A mutation stimulates cell spreading. +ATXN3 ataxin-3 DEUBIQUITINASE; DNA repair, damage; EC 3.4.19.12; Protease; Transcription regulation; Ubiquitin-specific protease P54252 4287 14q32.12 human K166-sm 31899108 GYSIFVVkGDLPDCE Josephin protein stabilization apoptosis, induced 23382880 1 0 0 +PTS PTS Cofactor and Vitamin Metabolism - folate biosynthesis; EC 4.2.3.12; Lyase; Mitochondrial Q03393 5805 11q23.1 human T58-p 1869465810 HNYKVVVtVHGEIDP PTPS molecular association, regulation; phosphorylation cell cycle regulation; carcinogenesis, induced; cell growth, induced; signaling pathway regulation LTBP1(INDUCES) 31628042 1 1 0 binds LTB1 subsequently stabilizing LTBP1-iNOS interaction, regulates LTBP1-TGF-? pathway, inhibits SMAD3 phosphorylation +ELL ELL Nuclear receptor co-regulator; Oncoprotein; Transcription initiation complex P55199 8178 19p13.11 human K5-ac 1875199402 ___MAALkEDRSYGL protein degradation 32152128 1 0 0 +PLCB1 PLCB1 Carbohydrate Metabolism - inositol phosphate; EC 3.1.4.11; Phospholipase Q9NQ66 23236 20p12.3 human S982-p 4787475 KKKSEPSsPDHGSST enzymatic activity, induced 11287604 1 1 0 S982 critical in IGF mediated activation of nuclear PI cycle +GRB10 GRB10 Adaptor/scaffold Q13322 2887 7p12.1 human Y67-p 448348 NASLESLySACSMQS molecular association, regulation INSR(DISRUPTS) 10871840 1 0 1 +PILRA PILRA Membrane protein, integral; Receptor, misc. Q9UKJ1 29992 7q22.1 human Y269-p 3141902 PKDDGIVyASLALSS molecular association, regulation SHP-1(INDUCES) 10660620 1 0 0 +DHCR24 Diminuto EC 1.3.1.72; Lipid Metabolism - steroid biosynthesis; Membrane protein, integral; Oxidoreductase Q15392 1718 1p32.3 human Y300-p 473188 LNSIGNYyKPWFFKH protein stabilization 24363437 1 0 1 +GABRB1 GABRB1 Channel, chloride; Channel, ligand-gated; Membrane protein, integral; Membrane protein, multi-pass; Transporter; Transporter, ion channel P18505 2560 4p12 human S409-p 451812 IQYRKPLsSREAYGR Neur_chan_memb activity, inhibited 28105535 4 0 0 orexin-mediated inhibition of the GABA-induced current +H4c2 H4 DNA-binding P62804 295277 rat K20-m1 1458623 GGAKRHRkVLRDNIQ CENP-T_C intracellular localization transcription, induced 33398850 30 15 7 increased lipid accumulation, activity of KMT5A and K20 methylation, in human and in rat placenta +Ptk2 FAK EC 2.7.10.2; KINASE; Kinase, protein; Protein kinase, TK; Protein kinase, tyrosine (non-receptor) P34152 14083 15 D3|15 33.94 cM mouse Y577-p 447890 YMEDSTYyKASKGKL PK_Tyr_Ser-Thr activity, induced; molecular association, regulation carcinogenesis, induced; cell growth, induced; cell adhesion, altered; transcription, altered; signaling pathway regulation P130Cas(INDUCES) 10672902; 36209205; 7529876; 9038154 88 40 1747 +FCRL6 FCRL6 Membrane protein, integral Q6DN72 343413 1q23.2 human Y371-p 12523300 GKDEGVVySVVHRTS molecular association, regulation SHP-2(INDUCES) 17213291 1 0 0 +EPHB1 EphB1 EC 2.7.10.1; KINASE; Kinase, protein; Membrane protein, integral; Protein kinase, TK; Protein kinase, tyrosine (receptor) P54762 2047 3q22.2 human Y928-p 3053617 SAIKMVQyRDSFLTA SAM_1 molecular association, regulation; phosphorylation cell motility, altered GRB7(INDUCES) 12223469 2 0 0 phosphorylation of Grb7 +PSEN1 PSEN1 Cell surface; EC 3.4.23.-; Membrane protein, integral; Membrane protein, multi-pass; Mitochondrial; Protease P49768 5663 14q24.2 human S365-p 3191053 RAAVQELsSSILAGE Presenilin protein conformation 28132667 2 15 1 PS1 pathogenic conformational shift +DDHD1 DDHD1 EC 3.1.1.-; Phospholipase Q8NEL9 80821 14q22.1 human S11-p 22351356 PGRGSPRsPEHNGRG intracellular localization; phosphorylation 34089703 1 7 12 regulates phosphorylation at other sites +Irf7 IRF7 DNA-binding; Transcription factor P70434 54123 7|7 F5 mouse S441-p 1276100 LCLSSTNsLYEDIEH transcription, induced DNA(INDUCES) 15743772 2 0 0 +Pdgfrb PDGFRB EC 2.7.10.1; KINASE; Kinase, protein; Membrane protein, integral; Oncoprotein; Protein kinase, TK; Protein kinase, tyrosine (receptor) Q05030 rat Y715-p 447524 CPPSTELySNALPVG PK_Tyr_Ser-Thr enzymatic activity, induced cell cycle regulation; cell growth, induced; signaling pathway regulation 23776396 5 1 2 downstream signaling pathway phosphorylation of STAT3, ERK1/2, Akt, and PLCG1 was determined in PDGF-stimulated VSMCs +Fmr1 FMR1 Nucleolus; RNA-binding; Translation P35922 14265 X A7.1|X 34.83 cM mouse R533-me 4046002 RRGDGRRrRGGGRGQ FXMRP1_C_core molecular association, regulation RNA(DISRUPTS) 20064924 2 0 0 methylation inhibits sc1 RNA binding; R533 and R538 determine association with polyribosomes; methylation doesnot inhibit AATYK mRNA association; different RNAs have distinct molecular requirements for binding to FMR1 +RIPK1 RIPK1 EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, Ser/Thr (non-receptor); Protein kinase, TKL Q13546 8737 6p25.2 human K140-ub 573768262 GVIHKDLkPENILVD PK_Tyr_Ser-Thr carcinogenesis, induced; cell growth, induced; apoptosis, inhibited; transcription, induced 37027301 1 3 0 TRIM21 affected the expression of the target genes of NF-kB R but not in PPDPF knockdown cells +Rb1 Rb Nuclear receptor co-regulator; Oncoprotein; Transcription, coactivator/corepressor; Tumor suppressor P33568 24708 15q11 rat S772-p 447978 STRPPTLsPIPHIPR Rb_C molecular association, regulation HDAC1(INDUCES) 19081374 98 17 128 +FASN FASN ACETYLTRANSFERASE; Acetyltransferase; EC 1.1.1.100; EC 1.3.1.39; EC 2.3.1.38; EC 2.3.1.39; EC 2.3.1.41; EC 2.3.1.85; EC 3.1.2.14; EC 4.2.1.59; Hydrolase; Lipid Metabolism - fatty acid biosynthesis; Lyase; Oxidoreductase P49327 2194 17q25.3 human T1032-p 27930801 NWVSFMDtMLQMSIL PS-DH transcription, inhibited 23585690 1 1 0 +UBA52-RPS27A-UBB-UBC ubiquitin Ubiquitin-like modifier P62988 2p16 human K6-ub 486300 __MQIFVkTLTGKTI ubiquitin protein degradation; molecular association, regulation; ubiquitination transcription, induced WRNIP1(INDUCES) DNA(INDUCES) 17550899; 32075857; 35659652 15 19 155 +ABCA1 ABCA1 Membrane protein, integral; Membrane protein, multi-pass; Transporter; Transporter, ABC family; Vesicle O95477 19 9q31.1 human Y1206-p 3718336 DIGHELTyVLPYEAA activity, inhibited 21402379 1 0 0 +Nlgn1 NLGN1 Membrane protein, integral Q99K10 192167 3|3 A3 mouse S839-p 1868546601 HPHPHSHsTTRV___ receptor recycling, inhibited; molecular association, regulation endocytosis, induced PSD-95(DISRUPTS) 31138690 1 1 0 regulates spinogenesis and excitatory synaptic transmission +MALT1 MALT1 Adaptor/scaffold; Apoptosis; EC 3.4.22.-; Ligase; Nuclear export; Protease; UBIQUITIN LIGASE; Ubiquitin conjugating system Q9UDY8 10892 18q21.32 human K648-ub 2134702 IDPKDANkGTPEETG MALT1_Ig protein degradation; molecular association, regulation IKKA(INDUCES) 17948050 2 3 0 activation of NF-kB pathway and IL-2 induction +STK3 MST2 Autophagy; EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, STE; Protein kinase, Ser/Thr (non-receptor) Q13188 6788 8q22.2 human Y81-p 25528501 MQQCDSPyVVKYYGS Pkinase molecular association, regulation; enzymatic activity, induced MST2(INDUCES); RAF1(DISRUPTS) 22590567 1 1 0 +Cish CISH O70512 83681 8q32 rat K187-ub 37044801 TPALPVSkPDAPGDP protein degradation 25448846 1 0 0 +SMAD3 SMAD3 DNA-binding; Nuclear receptor co-regulator; Transcription factor P84022 4088 15q22.33 human S208-p 451179 DAGSPNLsPNPMSPA protein degradation; intracellular localization; activity, inhibited; phosphorylation cell growth, induced; cell motility, inhibited; signaling pathway regulation; transcription, inhibited; transcription, altered; cell growth, altered 10197981; 15520018; 16156666; 20736297; 31722981; 33676893; 34504019 17 1 0 beta6 integrin expression; inhibits C-terminal phosphorylation and hence TGF-B signaling +RNMT RNMT EC 2.1.1.56; METHYLTRANSFERASE; Methyltransferase; RNA processing O43148 8731 18p11.21 human T77-p 454561 SSSCGKDtPSKKRKL enzymatic activity, induced cell growth, induced; translation, induced KPNA2(DISRUPTS) 26942677 1 27 11 +Ifngr2 IFNGR2 Membrane protein, integral Q63953 15980 mouse Y289-p 1341879204 IPEQIEEyLKDPDQF activity, induced; molecular association, regulation; intracellular localization EFHD2(INDUCES) 30318148 1 0 0 functional IFNGR2 formation, IFNG innate response +HIF1A HIF1A Autophagy; DNA-binding; Transcription factor Q16665 3091 14q23.2 human K532-ub 486268 SDMVNEFkLELVEKL protein degradation transcription, inhibited 10944113; 16862177 3 2 0 +HNRNPL hnRNP L RNA splicing; RNA-binding P14866 3191 19q13.2 human S544-p 15436636 GKSERSSsGLLEWES molecular association, regulation RNA(NOT_REPORTED) 22570490 1 4 0 +PCGF2 PCGF2 Transcription factor; UBIQUITIN LIGASE; Ubiquitin conjugating system; Ubiquitin ligase P35227 7703 17q12 human T334-p 34606690 TSRGRKMtVNGAPVP molecular association, regulation; ubiquitination carcinogenesis, induced; cell motility, induced; cell growth, induced; transcription, induced PHC1(DISRUPTS); CBX8(DISRUPTS) DNA(DISRUPTS) 33664452 1 1 1 inhibits H2A ubiquitination +MISP MISP Unknown function Q8IVT2 126353 19p13.3 human S376-p 3205356 GLHVGRAsTPDWVSE AKAP2_C molecular association, regulation ACTA1(DISRUPTS) 34023777 1 2 5 +TFE3 TFE3 DNA-binding; Oncoprotein; Transcription factor P19532 7030 Xp11.23 human S321-p 53350801 PAITVSNsCPAELPN activity, induced; intracellular localization autophagy, inhibited; transcription, inhibited; cell growth, altered 26813791; 29149494; 29945972 5 1 0 +APBB1 Fe65 Adaptor/scaffold; Apoptosis; Transcription regulation O00213 322 11p15.4 human K204-ac 1881304501 DGPREHSkSASLLFG transcription, induced 33938178 1 0 0 +Camk2a CAMK2A EC 2.7.11.17; KINASE; Kinase, protein; Protein kinase, CAMK; Protein kinase, Ser/Thr (non-receptor) P11798 12322 18 E1|18 34.41 cM mouse T286-p 447797 SCMHRQEtVDCLKKF activity, induced; molecular association, regulation; intracellular localization; protein conformation; phosphorylation; enzymatic activity, induced neural plasticity; signaling pathway regulation; cell growth, altered NMDAR1(INDUCES); Calmodulin(INDUCES); NMDAR2B(INDUCES) 12379661; 12408850; 18550767; 19004831; 19081380; 20381470; 21343908; 21627991; 22025701; 23467346; 23502535; 24038144; 24498331; 24812278; 28636948; 33064361; 33793303; 33853773; 35872016 155 34 72 +MFF MFF Membrane protein, integral; Mitochondrial Q9GZY8 56947 2q36.3 human S275-p 20651869 DNVRYGIsNIDTTIE Miff ubiquitination cell cycle regulation; cell growth, induced 34010649 1 2 0 inhibits ubiquitination and induces stability of Cyclin B1 +NEDD4L NEDD4L EC 6.3.2.-; EC 6.3.2.19; Ligase; UBIQUITIN LIGASE; Ubiquitin conjugating system; Ubiquitin ligase Q96PU5 23327 18q21.31 human T367-p 453439 AGRARSStVTGGEEP protein stabilization; phosphorylation ENaC-alpha(INDUCES) 15328345; 24657276 5 3 15 +STAT2 STAT2 DNA-binding; Transcription factor P52630 6773 12q13.3 human S734-p 60199700 LVPEPELsLDLEPLL transcription, induced 27802159 1 1 0 subset of IFN-stimulated antiviral genes +Nfatc2 NFAT1 DNA-binding; Transcription factor Q60591 18019 2 H3|2 88.91 cM mouse S170-p 449624 YREPLCLsPASSGSS activity, induced transcription, induced; transcription, inhibited 11030334; 15743762 2 1 0 +HBP1 HBP1 DNA-binding; Transcription factor O60381 26959 7q22.3 human K171-ac 25171018 AFPHHHWkEETPVRH transcription, inhibited 23249948 2 0 0 acetylation of the five sites induces transcriptional repression of the DNMT1 gene, regulates cellular senescence +Brsk2 BRSK2 EC 2.7.11.1; EC 2.7.11.26; KINASE; Kinase, protein; Protein kinase, CAMK; Protein kinase, Ser/Thr (non-receptor) D3ZML2 293631 1q41 rat T175-p 456031 VGDSLLEtSCGSPHY Pkinase intracellular localization; enzymatic activity, induced 29698519 5 1 1 activation of Sad kinases in the axon during development; Sad kinases are required for the survival of cortical neurons +CSNK1A1 CK1A EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, CK1; Protein kinase, Ser/Thr (non-receptor) P48729 1452 5q32 human S218-p 11333100 LMYFNRTsLPWQGLK Pkinase molecular association, regulation 14-3-3 eta(INDUCES) 19860830 1 0 0 +NTRK1 TrkA EC 2.7.10.1; KINASE; Kinase, protein; Membrane protein, integral; Oncoprotein; Protein kinase, TK; Protein kinase, tyrosine (receptor) P04629 4914 1q23.1 human Y701-p 2035400 MPPESILyRKFTTES PK_Tyr_Ser-Thr protein stabilization; molecular association, regulation; receptor internalization, altered; protein processing; enzymatic activity, inhibited; phosphorylation cell differentiation, altered; cell growth, altered LAMP1(INDUCES); CLTC(INDUCES) 18173729 1 0 1 Y701D mutation inhibits receptor autophosphorylation in vivo, but not in vitro +ALOX5 5-LO EC 1.13.11.34; Lipid Metabolism - arachidonic acid; Lipid Metabolism - linoleic acid; Nuclear envelope; Oxidoreductase P09917 240 10q11.21 human S664-p 461913 QLPYYYLsPDRIPNS enzymatic activity, induced 12670876; 36682398 5 1 0 +KDR VEGFR2 EC 2.7.10.1; KINASE; Kinase, protein; Membrane protein, integral; Protein kinase, TK; Protein kinase, tyrosine (receptor) P35968 3791 4q12 human Y951-p 447903 RFRQGKDyVGAIPVD PK_Tyr_Ser-Thr activity, induced; molecular association, regulation; receptor internalization, altered; phosphorylation; enzymatic activity, induced cell growth, induced; cell motility, altered PLCG1(INDUCES) 10102632; 11435426; 16891660; 28817576 20 0 3 +TCF3 E2A iso2 Cell development/differentiation; DNA-binding; Oncoprotein; Transcription factor P15923-2 6929 19p13.3 human S352-p 465681 SSNNFSSsPSTPVGS molecular association, regulation transcription, induced NEUROD1(INDUCES) 12810726 2 1 4 +SP1 SP1 C2H2-type zinc finger protein; DNA-binding; Transcription factor P08047 6667 12q13.13 human S698-p 5262507 CPKRFMRsDHLSKHI zf-C2H2 protein stabilization; molecular association, regulation carcinogenesis, induced; cell motility, induced; transcription, induced; signaling pathway regulation DNA(INDUCES) 22718198 1 1 0 AKT/SP1/CCR7 pathway +EDNRA EDNRA GPCR, family 1; Membrane protein, integral; Membrane protein, multi-pass; Motility/polarity/chemotaxis; Receptor, GPCR P25101 1909 4q31.22-q31.23 human S397-p 2911713 QSKSLMTsVPMNGTS receptor desensitization, induced 24064210 1 1 0 Lack of S397, T403 and S404 influences desensitization to a greater extent compared than S391, S393, and T396 +FOXO1 FOXO1A DNA-binding; Nuclear receptor co-regulator; Oncoprotein; Transcription factor Q12778 2308 13q14.11 human S235-p 4258802 NEGTGKSsWWMLNPE Forkhead molecular association, regulation DNA(DISRUPTS) 18786403 3 1 0 +Lpin1 LPIN1 EC 3.1.3.4; Phosphatase, lipid Q91ZP3 14245 12 A1.1|12 7.9 cM mouse S285-p 471346 SRPSTPKsDSELVSK molecular association, regulation; intracellular localization; phosphorylation 14-3-3 beta(INDUCES) 30617183 2 10 2 stimulates phosphorylation of S287 +ZRANB1 ZRANB1 DEUBIQUITINASE; EC 3.4.19.12; Ligase; Protease; Ubiquitin conjugating system; Ubiquitin-specific protease Q9UGI0 54764 10q26.13 human T117-p 1105513502 QRRTRSPtESPQSSG enzymatic activity, induced 29748601 1 1 0 phosphorylation induced by AKT induces K63 deubiquitinating activity toward Twist1 +Gabbr1 GABBR1 GPCR, family 3; Membrane protein, integral; Membrane protein, multi-pass; Receptor, GPCR Q9Z0U4 81657 20p12 rat S898-p 15167000 ITRGEWQsETQDTMK receptor recycling, inhibited; protein degradation; molecular association, regulation; ubiquitination MIB2(INDUCES) 29881949 3 0 1 +Ryr1 RYR1 Channel, calcium; Membrane protein, integral; Membrane protein, multi-pass; Transporter; Transporter, ion channel E9PZQ0 20190 7 B1|7 16.94 cM mouse T4338-p 34348504 ALLWALVtRAGGAGA protein degradation; ubiquitination 35469018 1 2 1 +Mip AQP0 Channel, misc.; Membrane protein, integral; Membrane protein, multi-pass; Transporter, aquaporin family P09011 25480 7q11 rat S241-p 451790 ILKGARPsDSNGQPE molecular association, regulation 22194645 2 1 0 No differences in the interaction with filensin between the AQP0 COOH-terminal peptide and its pseudophosphorylated proteins +POLI POLI DNA repair, damage; EC 2.7.7.7; Transferase Q9UNA4 11201 18q21.2 human K555-ub 12253556 SREKFQGkGSVSCPL protein degradation 26370087 1 6 1 +MLF2 MLF2 Cell adhesion Q15773 8079 12p13.31 human S28-p 13261776 AIHRQHMsRMLSGGF Mlf1IP activity, induced carcinogenesis, induced; cell growth, induced 31831854 1 2 0 +TELO2 TELO2 Adaptor/scaffold Q9Y4R8 9894 16p13.3 human S487-p 15668105 AQLAGSDsDLDSDDE molecular association, regulation; enzymatic activity, induced DNAPK(INDUCES); ATM(INDUCES); PIH1D1(INDUCES) 20864032; 24657168 4 2 0 increase stablization of DNA-PKs, ATM and PIKKs; this interaction (as a part of R2TP/prefoldin-like complex) is important for mTor and Smg1 stability +PDE3B PDE3B EC 3.1.4.17; Membrane protein, integral; Membrane protein, multi-pass; Nucleotide Metabolism - purine; Phosphodiesterase Q13370 5140 11p15.2 human S318-p 449873 CKIFRRPsLPCISRE molecular association, regulation; enzymatic activity, induced 14-3-3 beta(INDUCES); 14-3-3 eta(INDUCES) 17255105 7 18 27 +MAVS MAVS Adaptor/scaffold; Membrane protein, integral Q7Z434 57506 20p13 human K7-ub 27197145 _MPFAEDkTYKYICR CARD_2 protein degradation 26246171 2 2 0 inhibits RLR-mediated antiviral signaling +EEF1A1 EEF1A1 Nucleolus; Translation; Translation elongation P68104 1915 6q13 human K165-m1 8113920 TEPPYSQkRYEEIVK GTP_EFTU molecular association, regulation translation, altered L3MBTL iso4(INDUCES); EEF1D(DISRUPTS); eEF1B(DISRUPTS); EEF1G(DISRUPTS) 23583077; 28108655 2 8 46 +Limk1 LIMK1 EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, Ser/Thr (non-receptor); Protein kinase, TKL P53668 16885 5 74.73 cM|5 G2 mouse T508-p 447808 PDRKKRYtVVGNPYW PK_Tyr_Ser-Thr neural plasticity; cytoskeletal reorganization 35487245; 36044862 30 2 1 +CENPJ CENPJ Cell cycle regulation; Microtubule-binding; Transcription, coactivator/corepressor Q9HC77 55835 13q12.12-q12.13 human S467-p 31855585 LKCSNRKsLSPSGLK intracellular localization cell cycle regulation 26997271 1 6 0 mitotic spindle poles, CPAP-S467A has a high af?nity for MTs +Lmo7 LMO7 iso3 Adaptor/scaffold Q6JBI6 361084 15q21 rat S1295-p 50307600 LAGSVKTsPGSPSPR intracellular localization endocytosis, induced ATP1A1(INDUCES) 26370512 1 0 0 Na,K-ATPase endocytosis during hypercapnia +IL17RB IL17RB Membrane protein, integral Q9NRM6 55540 3p21.1 human Y447-p 5756439 LHKYVVVyFREIDTK SEFIR molecular association, regulation; ubiquitination; phosphorylation cell differentiation, inhibited; carcinogenesis, induced; cell growth, induced; transcription, induced; signaling pathway regulation TRIM56(INDUCES) 33658352 2 0 0 induces ERK phosphorylation and IL-17B/IL-17RB signal transduction +VPS4A VPS4A EC 3.6.4.6; Vesicle Q9UN37 27183 16q22.1 human K121-ub 573790636 MGAVVMEkPNIRWND molecular association, regulation; ubiquitination; enzymatic activity, induced CHMP1B(INDUCES) 35044214 1 2 0 interaction after HCV infection, enhances VPS4A ATPase activity, release of HCV particles +TGS1 PIMT EC 2.1.1.-; METHYLTRANSFERASE; Methyltransferase; Nuclear receptor co-regulator; RNA processing Q96RS0 96764 8q12.1 human S298-p 3636737 DLVSFPSsPIMVDND transcription, induced 24358311 2 3 2 PEPCK promoter binding and transcription, augment hepatic glucose output, and enhance gluconeogenic genes +Calm1 Calmodulin Calcium-binding; Protein phosphatase, regulatory subunit P0DP29 24242 6q32 rat T80-p 448704 MARKMKDtDSEEEIR molecular association, regulation; activity, inhibited KCNQ4(INDUCES) 15363395; 24627475; 8206911 11 6 0 accelrates SK channel deactivation; T80 site is key to binding. CAM phosphorylation regulates channel trafficking and stabilizes activity-thereby regulating neuronal excitability.; Calmodulin phosphorylated by CKII in vitro showed reduced activation of erythrocyte plasma membrane Ca2+ pump. +TRIOBP Tara iso5 Actin-binding; Cytoskeletal; Motility/polarity/chemotaxis Q9H2D6-5 11078 22q13.1 human T457-p 27171500 QAEEREHtLRRCQQE molecular association, regulation; intracellular localization cell cycle regulation TRF1(INDUCES) 22820163; 24692559 2 1 0 required for accurate chromosome segregation; localized to centrosome during mitosis +STAT6 STAT6 DNA-binding; Transcription factor P42226 6778 12q13.3 human K284-ac 1883988601 KQPPQVLkTQTKFQA molecular association, regulation; intracellular localization transcription, inhibited MLLT3(INDUCES) 37308587 1 1 0 attenuates the expression of genes involved in both purine metabolism and metastasis +Rela NFkB-p65 DNA-binding; Nuclear receptor co-regulator; Transcription factor Q04207 19697 19 A|19 4.34 cM mouse S276-p 447798 SMQLRRPsDRELSEP RHD_dimer activity, induced; protein degradation; acetylation; molecular association, regulation; protein processing cell differentiation, altered; apoptosis, altered; chromatin organization, altered; transcription, induced; transcription, inhibited; transcription, altered HDAC3(DISRUPTS); CDK9(INDUCES); p300(INDUCES); RELB(INDUCES); CBP(INDUCES); BRD4(INDUCES) 12874295; 16135789; 16192349; 17590163; 18408078; 19965984; 21900162; 30716535; 34474272; 35530146; 36223242; 9150141 90 0 0 +POU5F1 Oct4 DNA-binding; Transcription factor Q01860 5460 6p21.33 human S111-p 25236703 ESNSDGAsPEPCTVT protein degradation; ubiquitination; intracellular localization; activity, inhibited transcription, induced; transcription, altered 23024368; 33565603 4 2 0 +RAF1 RAF1 EC 2.7.11.1; KINASE; Kinase, protein; Oncoprotein; Protein kinase, Ser/Thr (non-receptor); Protein kinase, TKL P04049 5894 3p25.2 human S291-p 4274389 HSESASPsALSSSPN activity, induced cell cycle regulation 9933647 1 1 15 +Syn1 SYN1 Vesicle P09951 24949 Xq11 rat S576-gl 5505104 GPAPPKVsGASPGGQ phosphorylation 10386995 1 1 0 in the presnce of two GlcNAcs CaM Kinase II activity had a 66% increase in KM with no effect on Vmax or Kcat +Creb1 CREB iso1 DNA-binding; Transcription factor Q01147-1 12912 mouse K285-sm 12063903 PAEEAARkREVRLMK bZIP_1 cell differentiation, inhibited; transcription, induced 31433978 2 0 0 +TP53 p53 Activator; DNA-binding; Motility/polarity/chemotaxis; Nuclear receptor co-regulator; Transcription factor; Tumor suppressor P04637 7157 17p13.1 human K372-me 2344805 HSSHLKSkKGQSTSR activity, induced; molecular association, regulation; protein stabilization; acetylation cell cycle regulation; transcription, induced Tip60(INDUCES) 17646389; 18280244 5 0 0 K372-me stimulate p53 acetylation, thus enhancing the stability and activity of p53, which ultimately results in transcriptional upregulation (p21- cell cycle arrest) +Mc2r MC2R GPCR, family 1; Membrane protein, integral; Membrane protein, multi-pass; Receptor, GPCR Q64326 17200 18 E2|18 41.89 cM mouse S280-p 456325 PFIYAFRsPELRDAF receptor desensitization, altered; activity, inhibited 12456795 1 0 0 +RNH1 RNH1 Inhibitor P13489 6050 11p15.5 human K226-ub 12405189 LCGIVASkASLRELA LRR_6 protein degradation cell growth, induced; signaling pathway regulation 32521278 1 6 3 +RPL12 RPL12 Ribosomal; Translation P30050 6136 9q33.3 human S38-p 468652 KIGPLGLsPKKVGDD Ribosomal_L11_N cell cycle regulation; translation, induced 30220558 2 66 5 regulates translation of mitotic-related mRNAs +CD84 CD84 Cell surface; Immunoglobulin superfamily; Membrane protein, integral; Motility/polarity/chemotaxis Q9UIB8 8832 1q23.3 human Y316-p 454841 EEPVNTVySEVQFAD molecular association, regulation cell growth, altered SH2D1B(NOT_REPORTED); SH2D1B(INDUCES); Arg(NOT_REPORTED) 12928397; 23322602 1 8 203 +CBL CBL Adaptor/scaffold; EC 6.3.2.-; EC 6.3.2.19; Ligase; Motility/polarity/chemotaxis; Oncoprotein; UBIQUITIN LIGASE; Ubiquitin conjugating system; Ubiquitin ligase P22681 867 11q23.3 human S623-p 10288600 NRHSLPFsLPSQMEP molecular association, regulation 14-3-3 eta(INDUCES) 11024037 1 1 2 +Nr2c1 NR2C1 DNA-binding; Nuclear receptor Q505F1 22025 10 C2|10 48.81 cM mouse T210-p 4206803 SPLAATPtFVTDSET sumoylation; molecular association, regulation HDAC3(INDUCES); PML(INDUCES) 18682553; 19204783 2 1 0 triggers NR2C1 localization to promyelocytic leukemia (PML) nuclear bodies +Spi1 PU.1 DNA-binding; Oncoprotein; Transcription factor P17433 20375 2 E1|2 50.44 cM mouse S142-p 451055 EEEGERQsPPLEVSD activity, induced transcription, induced 12612065 2 2 0 +Ctnnd2 CTNND2 Actin-binding; Motility/polarity/chemotaxis O35927 18163 15|15 B2 mouse Y1112-p 473157 LKERKTDyESAGNNA protein stabilization; molecular association, regulation GSK3B(DISRUPTS) 24412473 1 0 6 increased ability of CTNND2 to enhance the nuclear distribution of B-catenin via E-cadherin +SRC Src EC 2.7.10.2; KINASE; Kinase, protein; Oncoprotein; Protein kinase, TK; Protein kinase, tyrosine (non-receptor) P12931 6714 20q11.23 human S75-p 450326 NSSDTVTsPQRAGPL protein degradation; ubiquitination; enzymatic activity, inhibited; enzymatic activity, induced; phosphorylation cytoskeletal reorganization; cell growth, altered 21442427; 9271228 9 24 3 +GALNT2 GALNT2 EC 2.4.1.41; Glycan Metabolism - O-glycan biosynthesis; Membrane protein, integral; Transferase Q10471 2590 1q42.13 human S373-ac 25336509 PYTFPGGsGTVFARN enzymatic activity, inhibited; O-GalNAc glycosylation 21651894 0 1 0 inhibits glycosylation of mucin +TRPS1 TRPS1 C2H2-type zinc finger protein; Transcription factor Q9UHF7 7227 8q23.3 human K1192-sm 3278912 TKAPPNVkNEGPLNV transcription, inhibited 17391059 2 0 0 +RELA NFkB-p65 DNA-binding; Nuclear receptor co-regulator; Transcription factor Q04206 5970 11q13.1 human K123-ac 458971 LGIQCVKkRDLEQAI RHD_DNA_bind molecular association, regulation; intracellular localization transcription, inhibited DNA(DISRUPTS) 12419806; 23087373 4 0 0 inhibits inflammatory gene expression +Cyth3 cytohesin 3 GEF; GEF, ARF; Lipid-binding; Nuclear receptor co-regulator; Receptor, misc. O08967 19159 5 G2|5 82.36 cM mouse T280-p 25585002 KLGGRVKtWKRRWFI PH molecular association, regulation; receptor recycling, induced; intracellular localization GLUT4(INDUCES) 22609160 1 0 0 Glut4 vesicle formation +Tfeb TFEB DNA-binding; Transcription factor Q9R210 21425 17 C|17 23.99 cM mouse S461-p 4785127 SPEASKAsSRRSSFS DUF3371 protein stabilization; intracellular localization autophagy, induced; transcription, induced 23599343; 35686465 2 0 0 +Tagln TAGLN Actin-binding; Motility/polarity/chemotaxis; Nuclear receptor co-regulator P31232 25123 8q22 rat T139-p 18016558 ALGSLAVtKNDGHYR CH protein degradation; molecular association, regulation IkB-alpha(DISRUPTS) 25937534 1 1 0 +AURKA AurA EC 2.7.11.1; KINASE; Kinase, protein; Oncoprotein; Protein kinase, Other; Protein kinase, Ser/Thr (non-receptor) O14965 6790 20q13.2 human S89-p 25157200 TSVPHPVsRPLNNTQ enzymatic activity, induced cell cycle regulation; cytoskeletal reorganization 22451695 1 0 0 +BLVRA BVR Cofactor and Vitamin Metabolism - porphyrin and chlorophyll; EC 1.3.1.24; KINASE; Kinase, protein; Oxidoreductase; Protein kinase, Ser/Thr (non-receptor) P53004 644 7p13 human S237-p 4774274 SFHFKSGsLENVPNV Biliv-reduc_cat enzymatic activity, induced 22584576 1 7 0 +AGO2 AGO2 EC 3.1.26.n2; RNA processing; RNA-binding Q9UKV8 27161 8q24.3 human Y749-p 13830224 HPTEFDFyLCSHAGI Piwi carcinogenesis, induced 31981897 1 1 0 +DDR1 DDR1 EC 2.7.10.1; KINASE; Kinase, protein; Membrane protein, integral; Protein kinase, TK; Protein kinase, tyrosine (receptor) Q08345 780 6p21.33 human Y569-p 1869973810 PQNSVPHyAEADIVT enzymatic activity, induced 32839343 1 1 0 +INSR INSR EC 2.7.10.1; KINASE; Kinase, protein; Membrane protein, integral; Protein kinase, TK; Protein kinase, tyrosine (receptor) P06213 3643 19p13.2 human T1375-p 450327 KKNGRILtLPRSNPS enzymatic activity, inhibited; phosphorylation 7615833; 8454604 6 1 8 +CEBPE C/EBP-epsilon DNA-binding; Motility/polarity/chemotaxis; Transcription factor Q15744 1053 14q11.2 human T74-p 455780 RGLKGPGtPAFPHYL molecular association, regulation cell differentiation, altered; transcription, induced NFkB-p65(INDUCES) DNA(INDUCES) 15677566; 17255362 2 0 6 +CALM1 Calmodulin Calcium-binding; Protein phosphatase, regulatory subunit P0DP23 801 14q32.11 human Y100-p 448707 FDKDGNGyISAAELR EF-hand_7 molecular association, regulation; intracellular localization TRPC6(DISRUPTS); PIK3R1(INDUCES) 26858457 5 75 2115 +Prkcd PKCD EC 2.7.11.13; KINASE; Kinase, protein; Nuclear receptor co-regulator; Protein kinase, AGC; Protein kinase, Ser/Thr (non-receptor); Protein kinase, tyrosine (non-receptor); Tumor suppressor P09215 170538 16p16 rat S643-p 448591 LNEKPQLsFSDKNLI Pkinase_C enzymatic activity, induced 16361709 29 51 79 +FOXO1 FOXO1A DNA-binding; Nuclear receptor co-regulator; Oncoprotein; Transcription factor Q12778 2308 13q14.11 human T317-gl 10902808 WSTFRPRtSSNASTI activity, induced transcription, induced 18420577 1 1 0 +ADRA1D ADRA1D GPCR, family 1; Membrane protein, integral; Membrane protein, multi-pass; Receptor, GPCR P25100 146 20p13 human S323-p 1424270002 DGAHGMRsAKGHTFR 7tm_1 receptor internalization, altered signaling pathway regulation 29551601 1 1 0 regulates ERK signaling pathway, induces calcium signaling de-sensitization +RAD17 RAD17 Cell cycle regulation O75943 5884 5q13.2 human S362-p 23136919 KKGMSLKsDAVLSKS molecular association, regulation RAD1(INDUCES) 29902452 1 0 1 +BUB1 BUB1 Cell cycle regulation; EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, Other; Protein kinase, Ser/Thr (non-receptor) O43683 699 2q13 human T609-p 465611 SAAQLAStPFHKLPV molecular association, regulation; intracellular localization; phosphorylation cell cycle regulation; signaling pathway regulation PLK1(INDUCES) 16760428; 33125045; 34551298 3 1 0 induces KNL1-MELT signaling; induces PLK1 recruitment +H3C1 H3 DNA-binding P68431 8350 6p22.2 human T80-p 4710889 EIAQDFKtDLRFQSS Histone cell cycle regulation; cell growth, induced 23227340 1 16 23 indicator of mitosis and tumor cell proliferation +Sod2 SOD2 EC 1.15.1.1; Mitochondrial; Oxidoreductase P09671 20656 17 A1|17 8.75 cM mouse K154-ac 27585065 WGWLGFNkEQGRLQI Sod_Fe_C protein conformation; enzymatic activity, altered 28433661 0 2 0 +CTNNB1 CTNNB1 Actin-binding; Cell adhesion; Motility/polarity/chemotaxis; Nuclear receptor co-regulator; Oncoprotein; Transcription factor P35222 1499 3p22.1 human Y333-p 471406 NIMRTYTyEKLLWTT protein stabilization; molecular association, regulation; ubiquitination; intracellular localization cell cycle regulation; carcinogenesis, induced; cell growth, induced; transcription, induced PKM(INDUCES) 22056988; 35697802 4 2 0 inhibits ubiquitination +Gapdh GAPDH Carbohydrate Metabolism - glycolysis and gluconeogenesis; EC 1.2.1.12; Oxidoreductase P16858 14433 6 F2|6 59.32 cM mouse K217-ac 474650 GAAKAVGkVIPELNG Gp_dh_C enzymatic activity, induced 27212436 1 7 1 induces glycolysis and memory T cell functions +H3f3b H3 iso3 DNA-binding P84244 15081 11|11 E2 mouse S28-p 455677 ATKAARKsAPSTGGV Histone activity, induced transcription, altered; cell growth, altered 15994958 50 18 0 +FADD FADD Adaptor/scaffold; Apoptosis Q13158 8772 11q13.3 human S194-p 447653 QNRSGAMsPMSWNSD intracellular localization; protein conformation cell cycle regulation; apoptosis, altered; carcinogenesis, altered; apoptosis, induced; apoptosis, inhibited 12702765; 12954630; 15001534; 15906275; 16061179; 18657552; 20890306; 21978935 15 28 0 apoptosis and necrosis +ETV6 Tel DNA-binding; Motility/polarity/chemotaxis; Oncoprotein; Transcription factor P41212 2120 12p13.2 human S213-p 451376 DNMIRRLsPAERAQG molecular association, regulation; activity, inhibited cell differentiation, altered; transcription, inhibited; cell growth, altered DNA(DISRUPTS) 15060146 1 37 2 +SMC3 SMC3 Cell cycle regulation; DNA repair, damage Q9UQE7 9126 10q25.2 human K105-ac 461824 LRRVIGAkKDQYFLD SMC_N protein stabilization; molecular association, regulation cell cycle regulation; DNA repair, induced; chromatin organization, altered; cell growth, induced; cytoskeletal reorganization DNA(INDUCES) 18614053; 20501661; 22101327; 22751501; 28847955; 29196537 7 10 180 regulates mitotic chromosome segregation and sister chromatid cohesion, ESCO2 KO has growth defects; Sister chromatid cohesion +POLR2A POLR2A EC 2.7.7.48; EC 2.7.7.6; Nucleotide Metabolism - purine; Nucleotide Metabolism - pyrimidine; Transcription initiation complex; Transferase P24928 5430 17p13.1 human S1616-p 450204 TPQSPSYsPTSPSYS RNA_pol_Rpb1_R molecular association, regulation; intracellular localization; enzymatic activity, inhibited; enzymatic activity, induced cell cycle regulation; DNA repair, induced; RNA splicing, altered; transcription, induced; transcription, altered; transcription, inhibited INTS11(INDUCES); TOP1(DISRUPTS); CTDSP1(INDUCES); CABIN1(INDUCES); SMN(INDUCES); UBN1(INDUCES); HIRA(INDUCES) DNA(INDUCES) 10995388; 11425311; 16641292; 17157258; 17259211; 18079403; 18757415; 20434984; 20457598; 20880846; 21070967; 22012619; 22195966; 23249733; 25470060; 25561469; 25620562; 26279188; 26527278; 26588990; 26700805; 27058666; 27068475; 34608337 81 4 0 PRC1 mediated repression is achieved by controlling transcriptional burst frequency +Hist3h2ba H2B DNA-binding D3ZNZ9 303175 10q22 rat K15-ac 458957 PAPKKGSkKAITKAQ Histone phosphorylation apoptosis, inhibited 20057502 8 9 468 inhibits phosphorylation at S14 +H3C1 H3 DNA-binding P68431 8350 6p22.2 human K23-ub 3932850 PRKQLATkAARKSAP Histone cell cycle regulation 25765655 1 5 99 regulation of DNA replication during S phase +CACYBP CACYBP Adaptor/scaffold; Ubiquitin conjugating system Q9HB71 27101 1q25.1 human S141-p 15343403 KPISVEGsSKKVKTD CS intracellular localization apoptosis, altered 20729913 1 0 0 +OPRL1 KOR-3 GPCR, family 1; Membrane protein, integral; Membrane protein, multi-pass; Receptor, GPCR P41146 4987 20q13.33 human S363-p 27150200 VALACKTsETVPRPA receptor internalization, induced; receptor desensitization, induced; phosphorylation signaling pathway regulation 23086955; 30914485 3 0 0 +MAD1L1 MAD1L1 Cell cycle regulation; Cytoskeletal Q9Y6D9 8379 7p22.3 human S598-p 18911590 AAASLPSsKEVAELK MAD molecular association, regulation cell cycle regulation Mad2(INDUCES) 29162720 1 1 0 +Notch1 Notch 1 Membrane protein, integral; Motility/polarity/chemotaxis; Oncoprotein; Receptor, misc.; Transcription factor Q01705 18128 2 A3|2 18.91 cM mouse K1785-ac 18899500 GEDSVGLkPLKNASD protein stabilization; ubiquitination 21499261 1 1 0 +Met Met EC 2.7.10.1; KINASE; Kinase, protein; Membrane protein, integral; Oncoprotein; Protein kinase, TK; Protein kinase, tyrosine (receptor) P16056 17295 6 A2|6 7.83 cM mouse S983-p 450188 PHLDRLVsARSVSPT enzymatic activity, inhibited 19595710 7 1 0 +LIMK2 LIMK2 EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, Ser/Thr (non-receptor); Protein kinase, TKL P53671 3985 22q12.2 human T494-p 467206 KATTKKRtLRKNDRK PK_Tyr_Ser-Thr protein stabilization; intracellular localization cell adhesion, induced 16820362; 22492986 2 0 0 +Npy1r NPY1R GPCR, family 1; Membrane protein, integral; Membrane protein, multi-pass; Receptor, GPCR P21555 29358 16p14 rat S359-p 2815300 STMHTDVsKTSLKQA receptor desensitization, altered; receptor internalization, altered 15576634 1 0 1 may be an artifact of the truncation mutants +SMAD1 SMAD1 DNA-binding; Transcription factor Q15797 4086 4q31.21 human K116-ub 1051003 CEFPFGSkQKEVCIN MH1 protein degradation 17963781 1 1 0 +Sqstm1 SQSTM1 Autophagy; Nuclear receptor co-regulator; Ubiquitin conjugating system Q64337 18412 11|11 B1.3 mouse S405-p 22264800 ESLSQMLsMGFSDEG UBA_5 exocytosis, inhibited; autophagy, induced; cytoskeletal reorganization; transcription, altered 28055010; 33528041; 36092812 30 7 0 +Gli2 GLI2 C2H2-type zinc finger protein; Oncoprotein; Transcription factor Q0VGT2 14633 1 E2.3|1 52.17 cM mouse K630-sm 25352004 CLHIKAIkTESSGLC molecular association, regulation transcription, inhibited HDAC5(INDUCES) 22549777 1 0 0 +CDC73 CDC73 Cell cycle regulation; Tumor suppressor Q6P1J9 79577 1q31.2 human K257-ub 41483948 FAILQSVkAREEGRA CDC73_N protein degradation; ubiquitination 35551175 1 3 0 +EIF5A2 EIF5A2 Q9GZV4 56648 3q26.2 human K85-ub 21173814 NMDVPNIkRNDYQLI eIF-5a protein degradation 35064108 1 10 0 regulate EMT, and may inhibit the metastasis of CRC +EPB41 EPB41 iso2 Cytoskeletal P11171-2 2035 1p35.3 human S679-p 467260 DKRLSTHsPFRTLNI SAB molecular association, regulation; intracellular localization cell cycle regulation NuMA-1(INDUCES); TUBA4A(INDUCES) 15525677 1 30 17 Also associates with tubulin and NuMA in vivo. Mutant EPB41 T60A-S679A abolishes localization to the mitotic spindle. +POLH POLH DNA repair, damage; EC 2.7.7.7; Transferase Q9Y253 5429 6p21.1 human K709-sm 1877365918 QTLESFFkPLTH___ intracellular localization; enzymatic activity, inhibited 32350109 1 1 0 +SGK2 SGK2 EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, AGC; Protein kinase, Ser/Thr (non-receptor) Q9HBY8 10110 20q13.12 human T193-p 456159 EPEDTTStFCGTPEY Pkinase transcription, inhibited 28911860 2 2 0 represses the PCK1 promoter +Nfatc2 NFAT1 DNA-binding; Transcription factor Q60591 18019 2 H3|2 88.91 cM mouse K684-sm 12057401 YHPVPAIkTEPSDEY sumoylation transcription, induced 15117942 1 0 0 Sumoylation of NFAT1-K897 +DDIT3 DDIT3 Autophagy; DNA-binding; Oncoprotein; Transcription factor P35638 1649 12q13.3 human S30-p 455503 EDLQEVLsSDENGGT protein degradation; ubiquitination; activity, inhibited transcription, inhibited 12876286; 27650555 2 0 0 +MAP1LC3B LC3B Autophagy; Microtubule-binding; Ubiquitin-like modifier; Vesicle Q9GZQ8 81631 16q24.2 human T50-p 37045604 QLPVLDKtKFLVPDH ATG8 molecular association, regulation autophagy, induced; autophagy, inhibited ATG7(DISRUPTS); NBR1(DISRUPTS); SQSTM1(DISRUPTS); STX17(DISRUPTS); FYCO1(DISRUPTS); ATG4B(DISRUPTS) 31857374; 34146484 3 1 0 +Slc12a3 NCCT Membrane protein, integral; Membrane protein, multi-pass; Transporter; Transporter, SLC family P55018 54300 19p13-p12 rat T48-p 4709842 SHLTHGStLYLRTFG AA_permease_N activity, induced 22966159 4 1 0 +SDC4 syndecan-4 Cell adhesion; Membrane protein, integral; Motility/polarity/chemotaxis P31431 6385 20q13.12 human Y180-p 474327 KKKDEGSyDLGKKPI Syndecan molecular association, regulation; intracellular localization; receptor recycling, altered endocytosis, induced; cell motility, induced syntenin(INDUCES) 23453597; 29109268 2 2 11 +Sgk1 SGK1 EC 2.7.11.1; KINASE; Kinase, protein; Motility/polarity/chemotaxis; Protein kinase, AGC; Protein kinase, Ser/Thr (non-receptor) Q9WVC6 20393 10|10 A3 mouse S422-p 448429 AEAFLGFsYAPPVDS Pkinase_C ubiquitination; phosphorylation; enzymatic activity, induced 34610303; 35058797 30 0 0 inhibits ENAC ubiquitination and degradation; induce AMPKA phosphorylation and inhibits AKT phosphorylation +MDC1 MDC1 Cell cycle regulation Q14676 9656 6p21.33 human T378-p 477989 ESQAGSDtDVEEGKA molecular association, regulation cell cycle regulation NBS1(INDUCES) 18678890 1 21 27 MDC1-NBS1 interaction regulates intra-S-phase checkpoint activation +Ptpa PPP2R4 EC 5.2.1.8; Motility/polarity/chemotaxis; Protein phosphatase, regulatory subunit P58389 110854 2 B|2 21.71 cM mouse K286-ub 573769710 SAVPSWSkVNQGLIR PTPA protein degradation; ubiquitination; methylation cytoskeletal reorganization 31160454 1 2 0 mediating the effects of UBE3A on spine morphology. +HIF1A HIF1A Autophagy; DNA-binding; Transcription factor Q16665 3091 14q23.2 human S643-p 470106 KILIASPsPTHIHKE activity, induced; protein stabilization; molecular association, regulation; intracellular localization apoptosis, inhibited; transcription, induced; transcription, altered HSPA9B(DISRUPTS); PIN1(INDUCES); Exportin-1(DISRUPTS) 16954218; 18687685; 26784107; 36825991 4 6 0 +Jun Jun Oncoprotein; Transcription factor P05627 16476 4 C5|4 43.34 cM mouse S63-p 447686 KNSDLLTsPDVGLLK Jun activity, induced; sumoylation; molecular association, regulation; acetylation cell differentiation, induced; cell growth, induced; apoptosis, induced; cell motility, altered; transcription, induced; transcription, altered; cell growth, altered HDAC3(DISRUPTS); EGR1(INDUCES); NFkB-p65(INDUCES) DNA(INDUCES) 10788439; 10851065; 12730213; 15122339; 16061693; 16964287; 18443042; 34962918; 36371601 133 43 4 +Kcnb1 Kv2.1 Channel, cation; Channel, ligand-gated; Channel, potassium; Membrane protein, integral; Membrane protein, multi-pass P15387 25736 3q42 rat S719-p 473557 LLDKPVLsPESSIYT activity, inhibited 16917065 4 3 0 +EGFR EGFR EC 2.7.10.1; KINASE; Kinase, protein; Membrane protein, integral; Oncoprotein; Protein kinase, TK; Protein kinase, tyrosine (receptor) P00533 1956 7p11.2 human K867-ub 1065305 KLLGAEEkEYHAEGG PK_Tyr_Ser-Thr receptor recycling, inhibited; protein degradation; protein stabilization 16543144; 17940017; 32669362 3 6 0 SMURF2-UBE2D1 protein?protein interaction affects mutant EGFR levels +AIRE AIRE Transcription factor O43918 326 21q22.3 human T68-p 1191300 ALLSWLLtQDSTAIL HSR protein degradation; molecular association, regulation; ubiquitination transcription, induced FBXO3(INDUCES) 17997173; 27365398 3 1 0 +NFE2 NF-E2 Cytoskeletal; DNA-binding; Transcription factor Q16621 4778 12q13.13 human K234-ub 11489905 ERRALAMkIPFPTDK protein degradation; ubiquitination transcription, inhibited 19966288 1 0 0 +CALD1 Caldesmon Actin-binding P12957 373965 chicken Y27-p 450224 LEAERLSyQRNDDDE molecular association, regulation SHC1(INDUCES) 10559276 1 2 13 +Slc24a2 SLC24A2 Membrane protein, integral; Membrane protein, multi-pass; Transporter; Transporter, SLC family O54701 84550 5q32 rat T476-p 471067 SLSWPSNtRKQITFL activity, induced 17038313 1 0 0 Mutation to alanine of T476 and either T166 or S504 (or possibly both) eliminates PDBu-induced enhancement (PIE) on the Na(+)/Ca(2+)+K(+) exchanger. +ZNF322 ZNF322A C2H2-type zinc finger protein; Transcription factor Q6U7Q0 79692 6p22.2 human T262-p 10990183 IVHQRVHtGEKPYKC activity, induced; protein stabilization carcinogenesis, induced; cell motility, induced; cell growth, induced; transcription, induced 31399647 1 5 1 +SIKE1 SIKE Cell adhesion Q9BRV8 80143 1p13.2 human S185-p 28076410 KELRELLsISSESLQ SIKE molecular association, regulation TBK1(DISRUPTS) 23649622 1 1 0 decreases inhibitory activity of SIKE (induces IRF3 phosphorylation) +VIM Vimentin Cytoskeletal; Motility/polarity/chemotaxis P08670 7431 10p13 human S5-p 471086 ___MSTRsVSSSSYR cell motility, altered 19291697 3 10 3 +HMGA1 HMGA1 DNA-binding P17096 3159 6p21.31 human K65-ac 458952 RGRPKGSkNKGAAKT AT_hook molecular association, regulation transcription, inhibited NFkB-p100(DISRUPTS) DNA(DISRUPTS) 11498590; 9809067 4 3 0 disrupts HMGA1/NF-kB cooperative complex and IFNB enhanceosome, prevents post induction turnoff in virus-induced ttanscription +Osbpl3 OSBPL3 iso3 Endoplasmic reticulum D3Z194 71720 6|6 B2.3 mouse S303-p 3212433 GPVRLHSsNPNLSTL apoptosis, inhibited 31509750 1 49 12 inhibits insulin secretion +REST REST C2H2-type zinc finger protein; Cell development/differentiation; DNA-binding; Transcription factor Q13127 5978 4q12 human S1030-p 37042902 MSEGSDDsGLHGARP protein degradation; ubiquitination carcinogenesis, induced; cell growth, induced 25453754; 29156689 2 1 0 +TNFAIP3 TNFAIP3 Apoptosis; DEUBIQUITINASE; EC 3.4.19.12; Protease; UBIQUITIN LIGASE; Ubiquitin conjugating system; Ubiquitin ligase P21580 7128 6q23.3 human T625-p 22778303 PENKGFCtLCFIEYR ubiquitination 26649818 1 1 18 cleavage of K63-linked tetraubiquitin ( all 4 sites or S381 alone), enhances ZnF4-mediated substrate ubiquitination +STAM2 STAM2 Adaptor/scaffold; Motility/polarity/chemotaxis O75886 10254 2q23.3 human Y374-p 449671 EAPVYSVySKLHPPA molecular association, regulation UBE2D2(DISRUPTS) 18626516 1 26 355 +LEF1 LEF-1 DNA-binding; Transcription factor Q9UJU2 51176 4q25 human S61-p 471385 KSSLVNEsEIIPASN CTNNB1_binding molecular association, regulation transcription, induced CTNNB1(INDUCES) 17113388 1 0 0 +Ctnnb1 CTNNB1 Actin-binding; Cell adhesion; Motility/polarity/chemotaxis; Nuclear receptor co-regulator; Oncoprotein; Transcription factor Q02248 12387 9 F4|9 72.19 cM mouse S45-p 447488 GATTTAPsLSGKGNP protein degradation; ubiquitination; intracellular localization transcription, altered 36989576; 9233789 57 7 0 +RBM17 RBM17 RNA splicing; RNA-binding; Spliceosome Q96I25 84991 10p15.1 human S266-p 27459081 QGLSTALsVEKTSKR G-patch molecular association, regulation; phosphorylation RNA splicing, inhibited; cell motility, induced RNA(DISRUPTS) 23519612 1 6 0 induced cell invasion, enhanced Cortactin phosphorylation at ERK-dependent sites +PDGFRA PDGFRA EC 2.7.10.1; KINASE; Kinase, protein; Membrane protein, integral; Oncoprotein; Protein kinase, TK; Protein kinase, tyrosine (receptor) P16234 5156 4q12 human Y731-p 448646 SFENNGDyMDMKQAD PK_Tyr_Ser-Thr molecular association, regulation PIK3R1(INDUCES) 11818394 2 6 31 +Nr2c2 NR2C2 DNA-binding; Nuclear receptor; Transcription factor P49117 22026 6|6 D1 mouse S19-p 467308 STDSAVAsPQRIQIV activity, inhibited transcription, altered 16887930 1 21 0 +WWTR1 TAZ Oncoprotein; Transcription, coactivator/corepressor Q9GZV5 25937 3q25.1 human S311-p 1244614 PYHSREQsTDSGLGL protein degradation; ubiquitination 22078877 3 1 8 +CENPT CENPT DNA replication F1NPG5 chicken T184-p 31870052 GSVMAPDtVEKRGLL CENP-T_N molecular association, regulation SPC25(INDUCES); SPBC24(INDUCES) 30420662 1 1 0 Fluorescence polarization, phospho-mimetic showed 65-fold increased affinity +PKN1 PKN1 EC 2.7.11.13; KINASE; Kinase, protein; Protein kinase, AGC; Protein kinase, Ser/Thr (non-receptor) Q16512 5585 19p13.12 human S916-p 452442 TGEAPTLsPPRDARP Pkinase_C enzymatic activity, induced carcinogenesis, induced; cell motility, induced; cell growth, induced 31981797 1 50 79 induces anchorage-independent cell growth +Grip1 GRIP1 Adaptor/scaffold P97879 84016 7q22 rat T956-p 480120 SQTTRSNtLPSDVGR molecular association, regulation cytoskeletal reorganization 14-3-3 beta(INDUCES); KIF5B(DISRUPTS) 24576423 1 18 24 interaction leads to releasing of GRIP1 from the kinesin-1 motor complex, increase dendritic arborization +DRD2 DRD2 iso2 GPCR, family 1; Membrane protein, integral; Membrane protein, multi-pass; Receptor, GPCR P14416-2 1813 11q23.2 human S325-p 467255 PNGKTRTsLKTMSRR 7tm_1 receptor desensitization, induced 23082996 2 0 0 PKC mediated receptor desensitization +FUS hnRNP P2 DNA-binding; Nuclear receptor co-regulator; Oncoprotein; RNA splicing; RNA-binding; SUMO LIGASE P35637 2521 16p11.2 human T338-p 1878186708 GKLKGEAtVSFDDPP molecular association, regulation hnRNP P2(DISRUPTS) 35753345 1 1 0 +HSP90AA1 HSP90A Chaperone; Heat shock protein P07900 3320 14q32.31 human K100-ac 2884402 DTGIGMTkADLINNL HATPase_c molecular association, regulation carcinogenesis, induced; exocytosis, induced CHIP(DISRUPTS); TEBP(DISRUPTS); HSP70(DISRUPTS); MMP2(INDUCES); HSP40(DISRUPTS) 18559531 1 2 1 +JAK3 JAK3 EC 2.7.10.2; KINASE; Kinase, protein; Protein kinase, TK; Protein kinase, tyrosine (non-receptor) P52333 3718 19p13.11 human Y904-p 2197001 SLRLVMEyLPSGCLR PK_Tyr_Ser-Thr phosphorylation; enzymatic activity, induced 18250158 1 0 0 required for STAT5A Y694 phosphorylation and its further transcriptional activation +PRPS1 PRPS1 Carbohydrate Metabolism - pentose phosphate pathway; EC 2.7.6.1; Kinase, other; Nucleotide Metabolism - purine P60891 5631 Xq22.3 human S103-p 56655989 RQDKKDKsRAPISAK Pribosyltran_N enzymatic activity, induced cell cycle regulation; carcinogenesis, induced; cell growth, induced; transcription, induced 31253668 1 2 0 increase CCND1 expression +BUB1B BUB1B EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, Other; Protein kinase, Ser/Thr (non-receptor); Tumor suppressor O60566 701 15q15.1 human T1008-p 7652107 LNANDEAtVSVLGEL enzymatic activity, induced cell cycle regulation 17376779 2 0 0 facilitates chromosome alignment during prometaphase +SH3GL1 endophilin A2 Oncoprotein; Vesicle Q99961 6455 19p13.3 human Y315-p 450745 QPSCKALyDFEPEND SH3_1 molecular association, regulation DYN1(DISRUPTS) 16054026 2 2 3 +NR1D1 NR1D1 Nuclear receptor; Transcription factor P20393 9572 17q21.1 human S55-p 471091 CPTYFPPsPTGSLTQ protein stabilization 16484495 1 0 2 +KLF13 KLF13 C2H2-type zinc finger protein; DNA-binding Q9Y2Y9 51621 15q13.3 human K225-ac 460601 YRTHTGEkKFSCPIC molecular association, regulation transcription, induced DNA(DISRUPTS) 12758070 1 0 3 +NR5A1 STF-1 Nuclear receptor; Transcription, coactivator/corepressor Q13285 2516 9q33.3 human K119-ub 11489901 QIRANGFkLETGPPM molecular association, regulation transcription, induced PITX1(INDUCES) 19995909 1 0 0 +GJA1 GJA1 Channel, misc.; Membrane protein, integral; Membrane protein, multi-pass; Motility/polarity/chemotaxis P17302 2697 6q22.31 human S262-p 450694 SPAKDCGsQKYAYFN molecular association, regulation; intracellular localization; protein conformation cell cycle regulation; endocytosis, induced; cell growth, inhibited; apoptosis, inhibited; cell growth, altered KCNJ8(INDUCES); KCNJ8(DISRUPTS); CLTA(INDUCES) 15605363; 16718370; 22737133; 22960107; 23828237; 24492000; 24815185 29 5 4 +WAC WAC Adaptor/scaffold Q9BTA9 51322 10p12.1|10p12.1-p11.2 human T482-p 469446 SSQPKVStPVVKQGP molecular association, regulation; phosphorylation cell cycle regulation PLK1(INDUCES) 30021153 1 5 18 +Pou3f2 Oct7 DNA-binding; Motility/polarity/chemotaxis; Transcription factor P31360 18992 4 A3|4 9.73 cM mouse S362-p 486486 RKRKKRTsIEVSVKG Homeodomain molecular association, regulation cell cycle regulation; cell motility, induced; transcription, induced; transcription, inhibited DNA(DISRUPTS) 22290434; 34168041 3 1 0 +TBX21 TBX21 DNA-binding; Transcription factor Q9UL17 30009 17q21.32 human Y266-p 20583306 VLQSLHKyQPRLHIV T-box molecular association, regulation cell differentiation, altered; cell growth, induced; transcription, induced DNA(INDUCES) 21690296 1 0 0 +PRPS1 PRPS1 Carbohydrate Metabolism - pentose phosphate pathway; EC 2.7.6.1; Kinase, other; Nucleotide Metabolism - purine P60891 5631 Xq22.3 human S180-p 18014261 GGAKRVTsIADRLNV protein conformation; activity, inhibited cell growth, inhibited 29074724 1 5 0 tumor cell growth inhibited; converts PRPS1/2 hexamers to monomers +RUNX3 AML2 DNA-binding; Transcription factor Q13761 864 1p36.11 human T151-p 6097702 SGRGKSFtLTITVFT Runt protein stabilization; intracellular localization cell cycle regulation; transcription, altered 18767071 1 1 0 +NR3C1 GR DNA-binding; Mitochondrial; Nuclear receptor; Transcription factor P04150 2908 5q31.3 human Y30-p 23111235 RGDVMDFyKTLRGGA GCR molecular association, regulation; intracellular localization; protein conformation DNAJC7(DISRUPTS) 30718983 1 0 3 phosphorylation of this site blocks an interaction of N-terminal (NTS) domain of GR with its C-terminal domain (LBD) +SKIL SKIL Cell development/differentiation; Transcription, coactivator/corepressor P12757 6498 3q26.2 human K440-ub 3144805 SISRQSEkAHSSGKL protein degradation signaling pathway regulation 11691834 1 0 0 TGF-beta signaling +Egfr EGFR EC 2.7.10.1; KINASE; Kinase, protein; Membrane protein, integral; Oncoprotein; Protein kinase, TK; Protein kinase, tyrosine (receptor) Q01279 13649 11 A2|11 9.41 cM mouse Y1018-p 448055 DVVDADEyLIPQQGF apoptosis, inhibited 16123117 45 7 12 +Plcb3 PLCB3 Carbohydrate Metabolism - inositol phosphate; EC 3.1.4.11; Phospholipase Q99JE6 29322 1q43 rat S26-p 448449 VETLRRGsKFIKWDE PH_14 enzymatic activity, inhibited 11278298 1 0 0 +STIM1 STIM1 Calcium-binding; Endoplasmic reticulum; Membrane protein, integral Q13586 6786 11p15.4 human S257-p 468872 GLHRAEQsLHDLQER protein conformation; activity, inhibited cytoskeletal reorganization; signaling pathway regulation 31381180 2 51 2 +Npr2 ANPB EC 4.6.1.2; Guanylyl cyclase; KINASE; Kinase, protein; Lyase; Membrane protein, integral; Nucleotide Metabolism - purine; Protein kinase, RGC; Protein kinase, dual-specificity (receptor); Receptor, misc. P16067 116564 5q22 rat S518-p 450025 AGSRLTLsLRGSSYG PK_Tyr_Ser-Thr activity, induced 9624142 2 1 0 +TRPV4 TRPV4 Channel, cation; Membrane protein, integral; Membrane protein, multi-pass Q9HBA0 59341 12q24.11 human S824-p 4777181 LRRDRWSsVVPRVVE activity, induced; molecular association, regulation; intracellular localization STIM1(DISRUPTS) 19661060; 25972993; 32186440 8 3 0 +Abi1 Abi-1 Adaptor/scaffold; Motility/polarity/chemotaxis Q8CBW3 11308 2 A3|2 15.18 cM mouse Y428-p 3589548 IEKVVAIyDYTKDKD SH3_1 molecular association, regulation cell adhesion, altered Abl(INDUCES) 21320496 1 4 4 enhances cell adhesion in Bcr-Abl expressing cells; induces the catalytic activity of c-Abl in vitro +CASP3 CASP3 Apoptosis; EC 3.4.22.56; Motility/polarity/chemotaxis; Protease P42574 836 4q35.1 human S150-p 450984 FRGDRCRsLTGKPKL Peptidase_C14 molecular association, regulation; activity, inhibited neural plasticity; apoptosis, inhibited GluR1(DISRUPTS) 14970175; 33176141 3 0 0 +GJA1 GJA1 Channel, misc.; Membrane protein, integral; Membrane protein, multi-pass; Motility/polarity/chemotaxis P17302 2697 6q22.31 human S372-p 465460 SRASSRAsSRPRPDD protein conformation 23828237 5 6 1 +EEF1A1 EEF1A1 Nucleolus; Translation; Translation elongation P68104 1915 6q13 human K55-m1 2584348 EMGKGSFkYAWVLDK GTP_EFTU molecular association, regulation L3MBTL iso4(INDUCES) 23583077 1 4 46 +Nr4a1 Nur77 Apoptosis; DNA-binding; Nuclear receptor P12813 15370 15|15 F1 mouse S151-p 1255792405 STPNFQPsQLSPWDG protein degradation; ubiquitination 30224829 1 0 0 regulates TNF-a mediated IL-6 production +NBN NBS1 Cell cycle regulation; DNA repair, damage O60934 4683 8q21.3 human K504-ac 487511 TPSLWKNkEQHLSEN phosphorylation cell cycle regulation; apoptosis, induced 17612497 2 1 0 inhibits phosphorylation at S343 +AIRE AIRE Transcription factor O43918 326 21q22.3 human S156-p 1191301 RGTASPGsQLKAKPP protein degradation; molecular association, regulation; ubiquitination transcription, induced FBXO3(INDUCES) 17997173; 27365398 3 1 0 +H2ac4 H2A.1 DNA-binding C0HKE1 319172 13|13 A3.1 mouse K5-ac 458908 ___SGRGkQGGKARA Histone protein degradation cell cycle regulation 31437213 12 9 145 Arrested round spermatids containing PSMA8 are involved in acetyation-dependent degradation of histones during prophase I. +H2AX H2AX DNA repair, damage; DNA-binding; Helicase P16104 3014 11q23.3 human K13-ub 55610203 TGGKARAkAKSRSSR Histone intracellular localization DNA repair, induced; carcinogenesis, inhibited; cell growth, inhibited 22980979; 27345151; 32213544 4 0 0 recruitment of 53BP1 to DNA break sites ; regulates recruitment of DNA repair factors to DSB sites via autophagy-regulated pathway +Swap70 SWAP-70 GEF; GEF, Rac/Rho Q6A028 20947 7 E3|7 57.7 cM mouse Y517-p 450716 RKQALEQyEGVKKKL molecular association, regulation cell motility, altered 21123826 1 2 134 critical for cell polarization; reduces SWAP-70 binding to F-actin +RPA2 RFA2 DNA replication P15927 6118 1p35.3 human S23-p 448337 GAGGYTQsPGGFGSP molecular association, regulation; intracellular localization cell cycle regulation; DNA repair, induced WRN(INDUCES) 17928296; 19671522; 20154705; 21107010; 26237679 7 3 0 +NRL NRL DNA-binding; Transcription factor P54845 4901 14q11.2-q12 human K20-sm 14988615 VNDFDLMkFEVKREP cell differentiation, induced; transcription, induced 20551322 1 0 0 +CSF3R GCSFR Membrane protein, integral; Receptor, cytokine Q99062 1441 1p34.3 human Y727-p 451101 LPTLVQTyVLQGDPR molecular association, regulation STAT3(INDUCES) 16493051 4 0 0 +TPD52 TPD52 Calcium-binding; Endoplasmic reticulum P55327 7163 8q21.13 human K163-ac 1881321500 SVGSVITkKLEDVKN molecular association, regulation; activity, inhibited carcinogenesis, inhibited; cell growth, inhibited; autophagy, inhibited HSC70(DISRUPTS) 34034634 1 1 0 inhibits CMA (chaperone-mediated autophagy ) +CD274 PD-L1 Membrane protein, integral Q9NZQ7 29126 9p24.1 human T285-p 1876861204 NSKKQSDtHLEET__ protein stabilization; molecular association, regulation carcinogenesis, induced SPOP(DISRUPTS) 35385574 1 1 0 inhibits ubiquitination +MVB12B FAM125B Vesicle Q9H7P6 89853 9q33.3 human K264-ub 15167002 VPFMISEkFSCVPES DUF2464 intracellular localization 20654576 1 0 0 +CDKN1B p27Kip1 Cell cycle regulation; Inhibitor; Oncoprotein; Protein kinase, regulatory subunit P46527 1027 12p13.1 human Y89-p 456819 GSLPEFYyRPPRPPK molecular association, regulation; intracellular localization; activity, inhibited cell cycle regulation CDK2(INDUCES); CDK4(INDUCES) 16195327; 17908796 8 0 0 When phosphorylated at Y88 or Y89, p27 able to bind but was unable to inhibit cdk4 in vitro and in vivo. +Ptk6 Brk EC 2.7.10.2; KINASE; Kinase, protein; Protein kinase, TK; Protein kinase, tyrosine (non-receptor) Q64434 20459 2 H4|2 103.62 cM mouse Y447-p 450276 KLTGITRyENLV___ enzymatic activity, inhibited RNA stability, altered KHDRBS1(INDUCES) 10913193 6 16 367 +CAMK2D CAMK2D EC 2.7.11.17; KINASE; Kinase, protein; Protein kinase, CAMK; Protein kinase, Ser/Thr (non-receptor) Q13557 817 4q26 human T287-p 450982 SMMHRQEtVDCLKKF molecular association, regulation; intracellular localization; enzymatic activity, induced Calmodulin(INDUCES); RNF8(INDUCES) 19884317; 34371035; 37468549 15 32 148 +HIF1A HIF1A Autophagy; DNA-binding; Transcription factor Q16665 3091 14q23.2 human K389-ac 3080901 DTSSLFDkLKKEPDA molecular association, regulation DNA(INDUCES) 18574470 1 0 0 +PLA2G4A PLA2G4A EC 3.1.1.4; EC 3.1.1.5; Lipid Metabolism - alpha-linolenic acid; Lipid Metabolism - arachidonic acid; Lipid Metabolism - ether lipid; Lipid Metabolism - glycerophospholipid; Lipid Metabolism - linoleic acid; Phospholipase P47712 5321 1q31.1 human S727-p 447599 RQNPSRCsVSLSNVE molecular association, regulation; intracellular localization; enzymatic activity, induced ANXA2(DISRUPTS); S100A10(DISRUPTS) Other(INDUCES) 18065419 8 33 0 activation and localization change (binding membranes) through release of ANXA2 +DACT1 DACT1 Adaptor/scaffold Q9NYF0 51339 14q23.1 human S237-p 18159801 GAVCRSLsTPQFNSL Dapper molecular association, regulation carcinogenesis, altered; cell growth, altered 14-3-3 beta(INDUCES) 21262972 1 1 0 ; modulates Wnt signaling +CFTR CFTR Channel, chloride; EC 3.6.3.49; Hydrolase; Membrane protein, integral; Membrane protein, multi-pass; Transporter; Transporter, ABC family P13569 1080 7q31.2 human S660-p 449979 FSAERRNsILTETLH CFTR_R activity, induced; molecular association, regulation; enzymatic activity, inhibited; protein conformation CFTR(INDUCES) 11053017; 14602047; 1716180; 25330774 9 8 0 S660A mutant is constitutively active; potentiates channel function +CCP110 CP110 Cell cycle regulation O43303 9738 16p12.3 human T566-p 35546004 NTRQQMDtPMVSCGN intracellular localization cell cycle regulation 12361598 1 0 0 +CLEC6A dectin-2 Membrane protein, integral Q6EIG7 93978 12p13.31 human K12-ub 56836804 QQPQSTEkRGWLSLR protein degradation 27432944 2 0 0 negative regulation of antifungal immune response +Dzip1 DZIP1 C2H2-type zinc finger protein Q8BMD2 66573 14|14 E4 mouse S665-p 13907506 TKTPPFSsEEEPDEE transcription, induced; signaling pathway regulation 21878643 1 0 0 involved in Gli1 nad Gli3 turnover pathway +Pdlim5 PDLIM5 Adaptor/scaffold Q8CI51 56376 3|3 H1 mouse S177-p 38546304 TPLHLSAsGLHVSAN molecular association, regulation cytoskeletal reorganization; cell motility, inhibited ARHGEF6(DISRUPTS) 25635515; 34368251 2 0 0 attenuates lamellipodia formation; decrease lamellipodia formation +MAP2K1 MEK1 EC 2.7.12.2; KINASE; Kinase, protein; Protein kinase, STE; Protein kinase, dual-specificity (non-receptor) Q02750 5604 15q22.31 human S212-p 448283 KLCDFGVsGQLIDSM Pkinase enzymatic activity, inhibited 12506122 5 2 3 +ZFP36L1 BRF1 Transcription factor Q07352 677 14q24.1 human S203-p 470146 PRLQHSFsFAGFPSA protein stabilization; molecular association, regulation cell growth, inhibited; transcription, altered; RNA stability, altered 14-3-3 beta(INDUCES) 17030608; 18326031; 26280535 3 1 20 inhibits BRF1-dependent AMD ( ARE-mediated mRNA decay); for its physiological effect phosphorylation of this site cooperates with phosphorylation of S90 and S92; senescence-associated secretory phenotype (SASP) +MITF MITF iso9 DNA-binding; Oncoprotein; Transcription factor O75030-9 4286 3p13 human S409-p 450265 KTSSRRSsMSMEETE DUF3371 activity, induced; protein degradation transcription, induced 10673502; 21749389 8 5 0 An MITF double mutant in which S73 and S409 are converted to alanines is both extremely stable and transcriptionally inactive. +Pde6g PDE6G EC 3.1.4.35; Nucleotide Metabolism - purine; Phosphodiesterase P09174 18588 11 E2|11 84.14 cM mouse T35-p 450149 PKFKQRQtRQFKSKP PDE6_gamma protein conformation; enzymatic activity, induced 17138607; 18305241 5 0 0 +KIF2A KIF2A Microtubule-binding; Motor O00139 3796 5q12.1 human S157-p 2150904 GPPSRRKsNCVKEVE intracellular localization cell cycle regulation; cytoskeletal reorganization 23960144 1 1 14 +CYLD CYLD DEUBIQUITINASE; EC 3.4.19.12; Protease; Tumor suppressor; Ubiquitin conjugating system; Ubiquitin-specific protease Q9NQC7 1540 16q12.1 human S444-p 12173910 PLSLSAQsVMEELNT CYLD_phos_site ubiquitination 15870263 2 1 0 induces ubiquitination of TRAF2 +REST REST C2H2-type zinc finger protein; Cell development/differentiation; DNA-binding; Transcription factor Q13127 5978 4q12 human S864-p 453739 TEDLSPPsPPLPKEN protein degradation; molecular association, regulation; protein conformation cell differentiation, inhibited; transcription, induced BTRC(INDUCES); RCOR1(DISRUPTS); PIN1(INDUCES) 25197063; 30217818 2 17 0 +Ahr AHR DNA-binding; Transcription factor P41738 25690 6q16 rat Y320-p 455230 LCNKGSGyQFIHAAD PAS_3 transcription, altered 15451023 2 0 0 +GYS1 GYS1 Carbohydrate Metabolism - starch and sucrose; EC 2.4.1.11; Transferase P13834 100008660 rabbit S657-p 449790 RHSSPHQsEDEEEPR Glycogen_syn enzymatic activity, inhibited; phosphorylation 10909964; 6819160; 7929255 14 31 20 simultaneous mutation of both NH2- and COOH-terminal sites was necessary to cause substantial increases in the activity ratio.; primes protein for GSK3 phosphorylation +RNF41 RNF41 EC 6.3.2.-; EC 6.3.2.19; Ligase; UBIQUITIN LIGASE; Ubiquitin conjugating system; Ubiquitin ligase Q9H4P4 10193 12q13.3 human S254-p 29675602 IENAHERsWPQGLAT USP8_interact cytoskeletal reorganization 24259665 1 0 0 required for epithelial cells to establish cell polarity, laminin-111 deposition on the basal surface of epithelial cells +Nlgn2 NLGN2 Membrane protein, integral Q69ZK9 216856 11|11 B3 mouse S714-p 487169 ELRCRRLsPPGGSGS molecular association, regulation; intracellular localization; protein conformation gephyrin(INDUCES); PIN1(INDUCES) 25297980 3 9 0 immobilization of GABAR at inhibitory synapses +HNF4A HNF4 alpha DNA-binding; Nuclear receptor; Transcription factor P41235 3172 20q13.12 human S142-p 458368 DRISTRRsSYEDSSL molecular association, regulation transcription, inhibited; signaling pathway regulation DNA(DISRUPTS) 21598922 4 4 6 PKA signaling pathway +GUCY2C GUCY2C EC 4.6.1.2; Guanylyl cyclase; KINASE; Kinase, protein; Lyase; Membrane protein, integral; Nucleotide Metabolism - purine; Protein kinase, RGC; Protein kinase, dual-specificity (receptor); Receptor, misc. P55204 397193 pig S1052-p 451300 RKPTRVAsYKKGTLE activity, induced 8797807 1 1 0 PMA treatment caused additional STa-mediated guanylyl-cyclase activation compared to control. +Piwil1 PIWIL1 Membrane protein, peripheral Q9JMB7 57749 5 G1.3|5 67.86 cM mouse R49-m1 9859902 TEGDLVGrGRQRGMV GAGE molecular association, regulation; intracellular localization TDRKH(INDUCES); TDRD9(INDUCES); TDRD1(INDUCES); TDRD6(INDUCES); TDRD7(INDUCES) 19584108 1 1 0 +FPR2 FPR2 GPCR, family 1; Membrane protein, integral; Membrane protein, multi-pass; Motility/polarity/chemotaxis; Receptor, GPCR P25090 2358 19q13.41 human T335-p 19075302 DSAPTNDtAANSASP receptor desensitization, induced; phosphorylation 21543323 1 0 0 +Atp5f1c ATP5C EC 3.6.3.14; Energy Metabolism - oxidative phosphorylation; Hydrolase; Mitochondrial Q91VR2 11949 2|2 A1 mouse K55-ac 11322790 MKMVAAAkYARAERE ATP-synt enzymatic activity, inhibited 36160705 1 5 0 K-55 site exhibited decreased enzymatic activity and ATP synthesis after irradiation +FLT3 FLT3 EC 2.7.10.1; KINASE; Kinase, protein; Membrane protein, integral; Oncoprotein; Protein kinase, TK; Protein kinase, tyrosine (receptor) P36888 2322 13q12.2 human Y572-p 466345 KYKKQFRyESQLQMV molecular association, regulation GRB10(INDUCES) 23246379 2 0 0 +SHC4 SHC4 Adaptor/scaffold Q6S5L8 399694 15q21.1 human Y375-p 3654471 EREDHEYyNEIPGKQ molecular association, regulation SHP-2(INDUCES) 28213521 1 2 4 +PARN PARN EC 3.1.13.4; Nucleolus; RNA-binding; Ribonuclease O95453 5073 16p13.12 human S557-p 483559 NHYYRNNsFTAPSTV cell cycle regulation 20932473 1 30 53 +Pde4a PDE4A EC 3.1.4.53; Nucleotide Metabolism - purine; Phosphodiesterase P54748 25638 8q13 rat S147-p 3189445 SFLYRSDsDYDMSPK molecular association, regulation; protein conformation AIP(DISRUPTS); DISC1(DISRUPTS) 21323643 1 10 2 +RPL11 RPL11 Motility/polarity/chemotaxis; Nucleolus; Ribosomal; Translation P62913 6135 1p36.11 human K8-ne 12067601 MAQDQGEkENPMREL protein stabilization; intracellular localization 19713960 1 0 0 +Atf2 ATF-2 ACETYLTRANSFERASE; C2H2-type zinc finger protein; EC 2.3.1.48; Transcription factor P16951 11909 2|2 C3 mouse T53-p 448225 IVADQTPtPTRFLKN protein stabilization carcinogenesis, induced; cell growth, induced; transcription, induced; transcription, altered 10521481; 21706057; 34346771 53 54 37 +SMN1 SMN RNA processing; RNA-binding Q16637 6606 5q13.2 human S180-p 27459811 SRSPGNKsDNIKPKS SMN molecular association, regulation; intracellular localization coilin(INDUCES) 24602413 1 4 0 +DES desmin Cytoskeletal; Motility/polarity/chemotaxis P17661 1674 2q35 human T77-p 449616 RASRLGTtRTPSSYG Filament_head cytoskeletal reorganization 12686604 1 0 0 Mutated desmin sites showed failure of desmin filaments to segregate into daughter cells. +PML PML iso4 Nucleolus; Oncoprotein; SUMO LIGASE; SUMO conjugating system; SUMO ligase; Transcription factor; Tumor suppressor; Ubiquitin conjugating system P29590-4 5371 15q24.1 human S38-p 451470 EGRQPSPsPSPTERA protein stabilization apoptosis, altered 15093545 2 11 0 Phosphorylation of PML is associated with enhanced sumoylation and apoptosis induced by As2O3. +DUSP4 DUSP4 EC 3.1.3.16; EC 3.1.3.48; PHOSPHATASE; Protein phosphatase, dual-specificity Q13115 1846 8p12 human S391-p 15412246 LHSPITTsPSC____ protein stabilization 25204653 2 1 2 +Tnip1 TNIP1 Transcription regulation Q9WUU8 57783 11|11 B1.3 mouse S83-p 1876350208 TSAPSLVsFDDLAEL protein degradation; molecular association, regulation; activity, inhibited autophagy, induced; signaling pathway regulation LC3A(INDUCES) 35213742 1 1 0 inhibits NF-kB activation and signaling pathway +FOXO3 FOXO3A Autophagy; DNA-binding; Oncoprotein; Transcription factor O43524 2309 6q21 human S344-p 2058401 QDDDAPLsPMLYSSS protein degradation; molecular association, regulation; activity, inhibited cell growth, altered MDM2(INDUCES) 18204439 2 2 0 promotes tumorigenicity +IRF3 IRF3 DNA-binding; Transcription factor Q14653 3661 19q13.33 human S339-p 2255400 FTEGSGRsPRYALWF IRF-3 protein degradation; molecular association, regulation transcription, inhibited; transcription, altered IRF3(INDUCES); PIN1(INDUCES); CBP(INDUCES) 16699525; 18272581; 35948267 4 2 0 +ATR ATR EC 2.7.11.1; KINASE; Kinase, protein; Membrane protein, integral; Protein kinase, Ser/Thr (non-receptor); Protein kinase, atypical Q13535 545 3q23 human T1578-p 22561302 SDLCQLStQTVFSML cell cycle regulation; cell growth, induced 21908846 1 1 0 +DNMT1 DNMT1 Amino Acid Metabolism - cysteine and methionine; Cell development/differentiation; EC 2.1.1.37; METHYLTRANSFERASE; Methyltransferase; Methyltransferase, DNA; Transcription regulation P26358 1786 19p13.2 human K1349-ac 25171003 SVVVDDKkFVSNITR DNA_methylase enzymatic activity, inhibited cell cycle regulation 21947282 1 1 0 +Cdk18 CDK18 Cell cycle regulation; EC 2.7.11.22; KINASE; Kinase, protein; Motility/polarity/chemotaxis; Protein kinase, CMGC; Protein kinase, Ser/Thr (non-receptor) Q04899 18557 1|1 E4 mouse S12-p 2192675 KNFKRRLsLSVPRPE phosphorylation; enzymatic activity, induced cytoskeletal reorganization 24831015 1 18 8 inhibits cofilin phosphorylation +ADD2 ADD2 Cytoskeletal; Motility/polarity/chemotaxis P35612 119 2p13.3 human S713-p 449802 KKKFRTPsFLKKSKK protein degradation; intracellular localization; phosphorylation cytoskeletal reorganization 16116087; 26639316; 9679146 8 58 159 +SLC2A4 GLUT4 Membrane protein, integral; Membrane protein, multi-pass; Transporter; Transporter, SLC family P14672 6517 17p13.1 human S274-p 478418 LERERPLsLLQLLGS Sugar_tr activity, induced 17382906 1 0 0 activation of glucose transport +Syn1 SYN1 Vesicle P09951 24949 Xq11 rat S566-p 456356 PQATRQAsISGPAPP phosphorylation 10386995 3 11 6 in the presnce of two GlcNAcs CaM Kinase II activity had a 66% increase in KM with no effect on Vmax or Kcat +Arrb2 ARRB2 Adaptor/scaffold P29067 25388 10q24 rat T383-p 455373 EFDTNYAtDDDIVFE molecular association, regulation; protein conformation signaling pathway regulation ERK2(INDUCES); ERK1(INDUCES) 28169830 5 3 2 +HIF1A HIF1A Autophagy; DNA-binding; Transcription factor Q16665 3091 14q23.2 human K11-ac 25126715 AGGANDKkKISSERR protein degradation transcription, inhibited 21917920; 28319066 2 0 0 +CEBPB C/EBP-beta DNA-binding; Motility/polarity/chemotaxis; Transcription factor P17676 1051 20q13.13 human S288-p 452156 NNIAVRKsRDKAKMR bZIP_2 intracellular localization 9374525 3 0 0 +NF2 Merlin Cytoskeletal; Motility/polarity/chemotaxis; Tumor suppressor P35240 4771 22q12.2 human S10-p 1720901 GAIASRMsFSSLKRK protein degradation; molecular association, regulation; ubiquitination carcinogenesis, induced; cell motility, altered; cytoskeletal reorganization VPRBP(DISRUPTS) 18071304; 21750658 5 10 0 +POU5F1 Oct4 DNA-binding; Transcription factor Q01860 5460 6p21.33 human K151-ac 57951803 KELEQFAkLLKQKRI Pou molecular association, regulation transcription, induced SOX2(INDUCES) 27369080 1 1 0 +JAK2 JAK2 EC 2.7.10.2; KINASE; Kinase, protein; Oncoprotein; Protein kinase, TK; Protein kinase, tyrosine (non-receptor) O60674 3717 9p24.1 human Y1007-p 448407 VLPQDKEyYKVKEPG PK_Tyr_Ser-Thr activity, induced; molecular association, regulation carcinogenesis, induced; cell motility, induced; cell growth, induced; cell adhesion, induced; apoptosis, inhibited; transcription, induced; signaling pathway regulation SOCS1(INDUCES) 16914724; 22177802; 22508938; 34118143; 34162728; 34380633; 34642304; 34900727; 35296317; 36516775 80 5 15 +Gria1 GluR1 Channel, calcium; Channel, ligand-gated; Membrane protein, integral; Membrane protein, multi-pass P23818 14799 11 B1.3|11 34.51 cM mouse T856-p 3362101 SINEAIRtSTLPRNS activity, induced 17689977 1 0 0 synaptic plasticity +LTF LTF EC 3.4.21.-; Protease; Secreted; Secreted, signal peptide P02788 4057 3p21.31 human K423-ub 41400405 GYVYTAGkCGLVPVL Transferrin ubiquitination 20404350 2 0 0 polyubiquitin acceptor site +PARP1 PARP1 DNA repair, damage; EC 2.4.2.30; Nuclear envelope; Nuclear receptor co-regulator; Nucleolus; Transferase P09874 142 1q42.12 human K203-sm 11539306 KKQLPGVkSEGKRKG protein degradation; molecular association, regulation; ubiquitination transcription, induced RNF4(INDUCES) 19779455 1 4 0 +HSF4 HSF4 Cell development/differentiation; DNA-binding; Transcription, coactivator/corepressor Q9ULV5 3299 16q22.1 human K293-sm 4037601 EKGLALLkEEPASPG sumoylation transcription, inhibited 16371476 1 0 0 SUMO-2 modification was induced by heat stress; sumoylation is depenedent on S298 phosphorylation +ABI1 Abi-1 Adaptor/scaffold; Motility/polarity/chemotaxis Q8IZP0 10006 10p12.1 human S216-p 3205884 VPNDYMTsPARLGSQ molecular association, regulation; intracellular localization; phosphorylation cell cycle regulation; cell growth, induced; cell motility, altered; cytoskeletal reorganization; signaling pathway regulation 21419341; 21900237 3 12 32 regulates WRC (WAVE2 regulatory complex) interaction with Arp2/3 and lamellipodial protrusion; inhibits tyrosine phosphorylation of itself and of WAVE2 by BCR-ABL, inhibits Abi1/WAVE2 signaling +GHR GH receptor Membrane protein, integral; Receptor, cytokine NP_999419 397488 pig Y534-p 486256 NFIMDNAyFCEADAK GHBP transcription, induced DNA(INDUCES) 8647880 3 0 0 +Tnnt2 TNNT2 Motility/polarity/chemotaxis; Motor P50753 24837 13q13 rat T205-p 449038 GYIQKAQtERKSGKR Troponin receptor desensitization, induced 26375298 6 0 0 +DCC DCC Immunoglobulin superfamily; Membrane protein, integral; Receptor, misc.; Tumor suppressor P43146 1630 18q21.2 human Y1420-p 454409 TEDSANVyEQDDLSE Neogenin_C molecular association, regulation RASA1(INDUCES); Lck(INDUCES); Fyn(INDUCES) 18253061; 26710849 5 0 0 +DLC1 DLC1 GAP; GAP, Rac/Rho; Tumor suppressor Q96QB1 10395 8p22 human S868-p 15500000 KELKRRNsSSSMSSR molecular association, regulation 14-3-3 theta(INDUCES) 32606003 2 5 2 +SORBS2 ArgBP2 iso2 Adaptor/scaffold; Motility/polarity/chemotaxis O94875-2 8470 4q35.1 human Y164-p 23083166 PDDDTDMyNTPYTYN protein conformation 24475245 1 0 4 reduced self-interaction +CERT1 COL4A3BP EC 2.7.11.9; KINASE; Kinase, protein; Lipid-binding; Protein kinase, Ser/Thr (non-receptor); Protein kinase, atypical Q9Y5P4 10087 5q13.3 human S147-p 125104504 ASGYSATsTSSFKKG molecular association, regulation; activity, inhibited 28652409 0 1 0 reduced PtdIns(4)P binding affinity as well as low ceramide transfer activity, E494R/N495K/P535R/E537K mutations, recovery of both PtdIns(4)P binding and ceramide transfer activity. +TUBA1A TUBA1A Cytoskeletal; Motility/polarity/chemotaxis Q71U36 7846 12q13.12 human K40-m3 62480700 DGQMPSDkTIGGGDD Tubulin cell cycle regulation; cell motility, induced; cytoskeletal reorganization 27594515; 34226540 3 1 0 crosstalk between TUBA1A K40me3 and a-TUBA1A K40ac ; promotes microtubule formation in neurons; TUBA1A K40me3 promotes tubulin nucleation and microtubule polymerization; neuronal migration in cerebral cortex during E14-E16 +CARD11 CARD11 Adaptor/scaffold Q9BXL7 84433 7p22.2 human S644-p 457638 NLMFRKFsLERPFRP activity, induced; molecular association, regulation transcription, induced AIP(INDUCES); Bcl-10(INDUCES) 24548923; 25245034 5 4 3 NF-kB activation, IL-2 production +CHD4 CHD-4 DNA-binding; EC 3.6.4.12; Helicase Q14839 1108 12p13.31 human S310-p 471449 SKRKRSSsEDDDLDV molecular association, regulation chromatin organization, altered; transcription, induced DNA(DISRUPTS); RNA(DISRUPTS) 29907651 1 14 5 +Ndel1 NDEL1 Microtubule-binding; Protease Q9ERR1 83431 11|11 B3 mouse S332-p 1869686802 PPPGLGSsRPSSAPG cell growth, induced; cell differentiation, induced; cytoskeletal reorganization 31815665 1 1 0 neuronal dendrite outgrowth and arborization +NR1H2 LXR-beta Nuclear receptor P55055 7376 19q13.33 human K447-sm 12004409 ALRLQDKkLPPLLSE molecular association, regulation transcription, inhibited coronin 2A(INDUCES) DNA(INDUCES) 17218271; 21331046 2 0 0 +H2AZ2 H2AFV Q71UI9 94239 7p13 human K13-ac 482540 GKDSGKAkAKAVSRS Histone molecular association, regulation transcription, induced FALZ(INDUCES) 32356653 1 2 95 K7ac preferentially engaging the binding site, acetylation at K7ac and K13ac is also the highest-affinity acetylation pattern of isoform I +RB1 Rb Nuclear receptor co-regulator; Oncoprotein; Transcription, coactivator/corepressor; Tumor suppressor P06400 5925 13q14.2 human T373-p 447982 VNVIPPHtPVRTVMN RB_A molecular association, regulation E2F1(DISRUPTS) 20223825 10 51 40 +PTGS2 COX-2 EC 1.14.99.1; Lipid Metabolism - arachidonic acid; Oxidoreductase P35354 5743 1q31.1 human Y446-p 484179 DQSRQMKyQSFNEYR An_peroxidase enzymatic activity, induced 24970799 1 1 0 +PGK1 PGK1 Carbohydrate Metabolism - glycolysis and gluconeogenesis; EC 2.7.2.3; KINASE; Kinase, other P00558 5230 Xq21.1 human K220-ac 14319999 GGAKVADkIQLINNM PGK enzymatic activity, inhibited 26356530 2 4 0 +GAPDH GAPDH Carbohydrate Metabolism - glycolysis and gluconeogenesis; EC 1.2.1.12; Oxidoreductase P04406 2597 12p13.31 human T246-p 23109023 NVSVVDLtCRLEKPA Gp_dh_C protein conformation signaling pathway regulation 23653351; 27129213 3 3 5 decreased GAPDH tetramerization; GAPDH/PKCD signaling to inhibit I/R-induced mitophagy +KHDRBS1 KHDRBS1 RNA-binding Q07666 10657 1p35.2 human R52-m2 476769 RGGGGGSrGGARASP intracellular localization 12529443 1 3 0 +CHAT CHAT iso3 ACETYLTRANSFERASE; Acetyltransferase; EC 2.3.1.6; Lipid Metabolism - glycerophospholipid P28329-3 1103 10q11.23 human T456-p 449058 VDNIRSAtPEALAFV Carn_acyltransf molecular association, regulation VCP(INDUCES) 12486117 1 1 0 +Runx1 AML1 DNA-binding; Oncoprotein; Transcription factor Q03347 12394 16 C4|16 53.7 cM mouse Y375-p 51211400 FQTGSPSyHLYYGAS RunxI activity, induced; protein stabilization transcription, induced HDAC1(DISRUPTS) DNA(INDUCES) 26598521 1 0 0 +RASSF1 RASSF1 iso2 Tumor suppressor Q9NS23-2 11186 3p21.31 human S197-p 18748000 RGPGRGTsVRRRTSF cytoskeletal reorganization 18514071 2 0 0 +Pla2g4a PLA2G4A EC 3.1.1.4; EC 3.1.1.5; Lipid Metabolism - alpha-linolenic acid; Lipid Metabolism - arachidonic acid; Lipid Metabolism - ether lipid; Lipid Metabolism - glycerophospholipid; Lipid Metabolism - linoleic acid; Phospholipase P47713 18783 1 G1|1 63.51 cM mouse S726-p 447599 RQNPSRCsVSLSNVE enzymatic activity, induced 10978317 8 33 0 +GYS1 GYS1 Carbohydrate Metabolism - starch and sucrose; EC 2.4.1.11; Transferase P13834 100008660 rabbit S641-p 448237 YRYPRPAsVPPSPSL Glycogen_syn enzymatic activity, inhibited 10909964; 16275910; 6402364; 7759494; 7929255; 8226927; 8546708 38 28 2 +LAT LAT Adaptor/scaffold; Membrane protein, integral O43561 27040 16p11.2 human Y255-p 448006 EEEGAPDyENLQELN LAT activity, induced; molecular association, regulation transcription, altered GRB2(INDUCES); PLCG1(INDUCES) 10811803 17 3 72 NF-AT mediated transcription +IL2RB IL2RB Membrane protein, integral; Receptor, cytokine P14784 3560 22q12.3 human T476-p 41591300 PQPLGPPtPGVPDLV transcription, induced 26152718 1 1 0 STAT5B transcriptional activity +Mapt Tau ACETYLTRANSFERASE; Acetyltransferase; Cytoskeletal P10637 17762 11 67.79 cM|11 E1 mouse T504-p 447934 TPGSRSRtPSLPTPP neural plasticity 33428131 52 16 5 +VIPR1 VIPR1 GPCR, family 2; Membrane protein, integral; Membrane protein, multi-pass; Motility/polarity/chemotaxis; Receptor, GPCR P32241 7433 3p22.1 human S250-p 455875 LLAVSFFsERKYFWG 7tm_2 receptor internalization, altered 15932876 2 0 0 +HMGB2 HMGB2 DNA-binding; Nuclear receptor co-regulator P26583 3148 4q34.1 human K3-ac 460591 _____MGkGDPNKPR chromatin organization, altered 15005629 1 1 0 +Clip1 Restin Cytoskeletal Q9JK25 65201 12q16 rat T286-p 483203 KIGFPSTtPAKAKAA intracellular localization cell cycle regulation 19687009 3 6 3 essential for G2/M transition and cell cycle progression +VCL Vinculin Cell adhesion; Cytoskeletal; Motility/polarity/chemotaxis P12003 396422 chicken Y1134-p 454003 WVRKTPWyQ______ activity, induced; molecular association, regulation; intracellular localization; protein conformation cell adhesion, altered VASP(INDUCES) 15229287; 19422016; 21071443; 25759389 9 1 22 phosphorylation of this site positively regulates cell spreading; plays an important role in vinculin exchange dynamics +MYBL2 B-Myb DNA-binding; Motility/polarity/chemotaxis; Transcription factor P10244 4605 20q13.12 human T520-p 450112 DNTPHTPtPFKNALE Cmyb_C molecular association, regulation; protein conformation transcription, induced DNA(INDUCES) 35926712 3 1 9 +CDK4 CDK4 Cell cycle regulation; EC 2.7.11.22; KINASE; Kinase, protein; Protein kinase, CMGC; Protein kinase, Ser/Thr (non-receptor) P11802 1019 12q14.1 human T172-p 448476 YSYQMALtPVVVTLW Pkinase enzymatic activity, induced cell cycle regulation; carcinogenesis, induced; cell growth, induced 16782892; 19237555; 20484410; 23737759; 36446794; 36453028 12 4 3 +LIME1 LIME1 Adaptor/scaffold; Membrane protein, integral Q9H400 54923 20q13.33 human Y254-p 463811 SGPLENVyESIRELG LIME1 molecular association, regulation Lck(INDUCES); Fyn(INDUCES) 14610046 3 3 13 +M Membrane Protein P0DTC5 43740571 SARSCoV2 K15-ub 1881871200 ITVEELKkLLEQWNL molecular association, regulation exocytosis, induced Envelope Protein(INDUCES) 35100873 1 0 0 enhancing the interaction of viral envelope with membrane, virus-like particle (VLP) release +CHRNA7 nAChRA7 Channel, cation; Channel, ligand-gated; Membrane protein, integral; Membrane protein, multi-pass P36544 1139 15q13.3 human Y386-p 457466 ASNGNLLyIGFRGLD Neur_chan_memb activity, inhibited 16251431 1 0 0 +TTK TTK Cancer Testis Antigen (CTA); EC 2.7.12.1; KINASE; Kinase, protein; Protein kinase, Other; Protein kinase, dual-specificity (non-receptor) P33981 7272 6q14.1 human T806-p 4145514 NQMAKGTtEEMKYVL enzymatic activity, inhibited 18680479 1 0 0 in vitro +HSPA1A HSP70 Chaperone; Heat shock protein; Motility/polarity/chemotaxis P0DMV8 3303 6p21.33 human S631-p 483567 AQGPKGGsGSGPTIE activity, induced; protein stabilization; intracellular localization apoptosis, induced CHIP(DISRUPTS) 24623308; 30485823 2 13 0 spindle elongation; Promotes deubiquitination and stabilization of HSP70 along with SOD2 import and stabilization, regulates mitochondrial redox balance +EDNRA EDNRA GPCR, family 1; Membrane protein, integral; Membrane protein, multi-pass; Motility/polarity/chemotaxis; Receptor, GPCR P25101 1909 4q31.22-q31.23 human T396-p 2911714 YQSKSLMtSVPMNGT receptor desensitization, induced 24064210 1 1 0 Lack of S397, T403 and S404 influences desensitization to a greater extent compared than S391, S393, and T396 +GATA1 GATA1 DNA-binding; Transcription factor P15976 2623 Xp11.23 human K315-ac 466358 KASGKGKkKRGSSLG molecular association, regulation transcription, altered DNA(INDUCES) 16888089 1 0 0 +Elk1 ELK1 DNA-binding; Transcription factor A4GTP4 314436 Xq11 rat K229-sm 3982502 PPEAPNQkSEELSLN apoptosis, inhibited; transcription, inhibited 30849179 6 2 0 GADD45A expression; APP/PS1 rats +CD5 CD5 Cell surface; Membrane protein, integral P06127 921 11q12.2 human T434-p 450129 MSFHRNHtATVRSHA activity, induced; receptor internalization, altered 11123317 1 0 44 +Glra3 GLRA3 Membrane protein, integral; Membrane protein, multi-pass; Transporter; Transporter, ion channel P24524 rat S379-p 1848000 TDDEVREsRLSFTAY Neur_chan_memb protein conformation 23834509 2 0 0 +Nr4a3 NR4A3 DNA-binding; Nuclear receptor; Oncoprotein Q9QZB6 18124 4|4 B1 mouse S139-p 1874485100 TSMYFKQsPPSTPTT sumoylation; protein stabilization; activity, inhibited cell growth, inhibited; apoptosis, induced; transcription, altered 34383980 1 0 0 induces sumoylation at K137 +Noxa1 NOXA1 Activator Q8CJ00 241275 2|2 A3 mouse Y252-p 1869151102 GHTSPGLyDSLLASR activity, inhibited 20230789 1 0 0 inhibits Nox1 activity +Myc Myc DNA-binding; Nucleolus; Oncoprotein; Transcription factor P01108 17869 15 D1|15 26.19 cM mouse T373-p 450960 EENDKRRtHNVLERQ HLH activity, inhibited cell cycle regulation; apoptosis, inhibited; transcription, altered; transcription, inhibited; cell growth, altered 14749374; 20043278 6 0 0 mutation of this site enhances epidermal differentiation +Smyd2 SMYD2 EC 2.1.1.43; METHYLTRANSFERASE; Methyltransferase; Methyltransferase, protein lysine Q8R5A0 226830 1|1 H6 mouse Y240-p 4144300 GDEVFTSyIDLLYPT SET methylation; enzymatic activity, induced 16805913 1 0 0 induces histone methylation +NTRK1 TrkA EC 2.7.10.1; KINASE; Kinase, protein; Membrane protein, integral; Oncoprotein; Protein kinase, TK; Protein kinase, tyrosine (receptor) P04629 4914 1q23.1 human Y681-p 447764 DIYSTDYyRVGGRTM PK_Tyr_Ser-Thr receptor internalization, altered; enzymatic activity, induced 15601748 14 3 6 +Pdcd4 PDCD4 Apoptosis; Tumor suppressor Q61823 18569 19 D2|19 48.73 cM mouse S457-p 458382 RGRKRFVsEGDGGRL translation, inhibited 28644433 8 74 46 +NR3C1 GR DNA-binding; Mitochondrial; Nuclear receptor; Transcription factor P04150 2908 5q31.3 human S617-p 1872513503 WRSYRQSsANLLCFA Hormone_recep molecular association, regulation 14-3-3 zeta(INDUCES) 33744286 1 1 0 +Kras KRas iso2 G protein; G protein, monomeric; G protein, monomeric, Ras; Motility/polarity/chemotaxis; Oncoprotein P32883-2 16653 6 G3|6 77.37 cM mouse S181-p 459210 GKKKKKKsRTRCTVM molecular association, regulation transcription, induced Calmodulin(DISRUPTS) 26590425 10 0 0 increase in Fzd8 promoter activity, and of NF-AT transcription +CHAT CHAT iso3 ACETYLTRANSFERASE; Acetyltransferase; EC 2.3.1.6; Lipid Metabolism - glycerophospholipid P28329-3 1103 10q11.23 human S476-p 454037 HKAAVPAsEKLLLLK Carn_acyltransf enzymatic activity, induced 15381704 1 0 0 +HCRTR1 HCRTR1 GPCR, family 1; Membrane protein, integral; Membrane protein, multi-pass; Receptor, GPCR O43613 3061 1p35.2 human S262-p 1869999600 VRNWKRPsDQLGDLE 7tm_1 receptor internalization, induced; molecular association, regulation endocytosis, induced GRK2(INDUCES); AP-2 alpha(INDUCES) 32827691 1 1 0 +CHEK2 Chk2 EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, CAMK; Protein kinase, Ser/Thr (non-receptor); Tumor suppressor O96017 11200 22q12.1 human S164-p 12473002 IAYIEDHsGNGTFVN FHA enzymatic activity, inhibited cell cycle regulation 20126263 1 1 0 mutation of this site impairs checkpoint recovery +YAP1 YAP1 Oncoprotein; Transcription, coactivator/corepressor P46937 10413 11q22.1 human T110-p 452306 SHSRQAStDAGTAGA protein degradation 25660024 3 22 274 +APPL1 APPL Adaptor/scaffold; Nuclear receptor co-regulator Q9UKG1 26060 3p14.3 human K160-ub 40212807 KRENDKVkYEVTEDV BAR_3 intracellular localization 23909487 1 2 0 Akt activation and gluconeogenesis +Ppm1h PPM1H EC 3.1.3.16; PHOSPHATASE; Phosphatase Q3UYC0 319468 10|10 D2 mouse S123-p 479930 RNSKRRSsLPNGEGL phosphorylation; enzymatic activity, induced 32600616 1 30 14 phosphorylation at S210; dephosphorylation of SMAD1 +Gata4 GATA4 Motility/polarity/chemotaxis; Transcription factor P46152 54254 15p12 rat S105-p 449604 AYTPPPVsPRFSFPG GATA-N activity, induced; molecular association, regulation; intracellular localization; phosphorylation cell growth, induced; apoptosis, inhibited; transcription, induced; signaling pathway regulation; transcription, altered DNA(INDUCES) 11585926; 12468531; 17227882; 19546173; 21702924; 22227582; 22228770; 22473995; 32060996; 36279967 16 0 0 +KCNMA1 KCNMA1 Channel, potassium; Endoplasmic reticulum; Membrane protein, integral; Membrane protein, multi-pass Q8AYS8 374065 chicken T871-p 4715376 QANSQGFtPPGMDRS intracellular localization; activity, inhibited 22094329 1 2 0 +TP53 p53 Activator; DNA-binding; Motility/polarity/chemotaxis; Nuclear receptor co-regulator; Transcription factor; Tumor suppressor P04637 7157 17p13.1 human K24-ub 60176101 ETFSDLWkLLPENNV P53_TAD intracellular localization cell growth, inhibited; apoptosis, inhibited BAK1(INDUCES); MCL1(DISRUPTS) 27818144 1 0 0 inhibits p53 mitochondrial localization +BIK BIK Apoptosis; Membrane protein, integral; Mitochondrial Q13323 638 22q13.2 human S124-p 32001602 NIMRFWRsPNPGSWV bcl-2I13 protein degradation; ubiquitination carcinogenesis, induced; apoptosis, inhibited 24637719 1 0 0 BIK phosphodeficient mutant enhanced anti-tumor effects of 5-FU +SUN1 SUN1 iso9 Cytoskeletal; Membrane protein, integral O94901-9 23353 7p22.3 human S48-p 7101126 KLDPVFDsPRMSRRS intracellular localization 25482198 1 13 0 accumulation in the ER +DMTN dematin iso2 Actin-binding; Motility/polarity/chemotaxis; Tumor suppressor Q08495-2 2039 8p21.3 human S381-p 450255 NELKKKAsLF_____ VHP protein conformation cytoskeletal reorganization 23355471 5 0 0 Phosphorylation of S381 eliminates the F-actin bundling activity, induced a compact quartenary structure, and caused the headpiece to associate with the core domain. +RHO Rhodopsin GPCR, family 1; Membrane protein, integral; Membrane protein, multi-pass; Receptor, GPCR P08100 6010 3q22.1 human S338-p 448679 DEASATVsKTETSQV molecular association, regulation ARRB1(INDUCES) 28753425 8 7 0 +SHC1 SHC1 iso2 Adaptor/scaffold; Apoptosis; Mitochondrial; Motility/polarity/chemotaxis P29353-2 6464 1q21.3 human Y410-p 23144113 STTTPGQyVLTGLQS SH2 molecular association, regulation JAK3(INDUCES) 24795043 1 0 5 +KDM1A LSD1 DEMETHYLASE; Demethylase; EC 1.-.-.-; Nuclear receptor co-regulator; Oxidoreductase; Transcription factor O60341 23028 1p36.12 human S137-p 449181 LSEDEYYsEEERNAK molecular association, regulation; ubiquitination; intracellular localization cell growth, induced RNF168(INDUCES) 25999347 1 46 275 recruited to sites of DNA damage, promotes the interaction between 53BP1 and RNF168 in chromatin, RNF168-dependent 53BP1 ubiquitination +Nr3c1 GR DNA-binding; Mitochondrial; Nuclear receptor; Transcription factor P06536 24413 18p11 rat S155-p 3178932 ANLNRSTsVPENPKS GCR intracellular localization transcription, induced 23878391 12 11 6 +BTLA BTLA Membrane protein, integral Q7Z6A9 151888 3q13.2 human Y282-p 463077 VKEAPTEyASICVRS phosphorylation signaling pathway regulation 32437509 1 0 6 inhibits IL2 production, phosphorylation of CD3Z and CD28, and hence T cell signaling +SMURF1 SMURF1 EC 6.3.2.-; EC 6.3.2.19; Ligase; UBIQUITIN LIGASE; Ubiquitin conjugating system; Ubiquitin ligase Q9HCE7 57154 7q22.1 human K383-ub 1872850900 RDLVQKLkVLRHELS protein degradation 21572392 1 0 0 +POLB POLB DNA repair, damage; DNA replication; EC 2.7.7.7; Lyase; Transferase P06746 5423 8p11.21 human K41-ub 12723501 HKYNAYRkAASVIAK HHH_8 protein degradation DNA repair, inhibited 19713937 1 2 0 +Aqp2 AQP2 Channel, misc.; Membrane protein, integral; Membrane protein, multi-pass; Transporter; Transporter, aquaporin family P56402 11827 15 F1|15 56.13 cM mouse S269-p 3339002 PQSLPRGsKA_____ protein stabilization; molecular association, regulation; intracellular localization endocytosis, induced; endocytosis, altered; endocytosis, inhibited 14-3-3 theta(INDUCES); 14-3-3 zeta(INDUCES); HSP70(DISRUPTS); SIPA1L1(DISRUPTS) 18606813; 19966308; 23935101; 24876223; 26645691; 28336531; 32799672; 36823952 37 5 0 +FGFR2 FGFR2 EC 2.7.10.1; KINASE; Kinase, protein; Membrane protein, integral; Oncoprotein; Protein kinase, TK; Protein kinase, tyrosine (receptor) P21802 2263 10q26.13 human S782-p 2532302 PLEQYSPsYPDTRSS molecular association, regulation cell cycle regulation; cell growth, altered 14-3-3 zeta(INDUCES) 18332103 2 0 0 reguates cell survival in response to FGF2 +Nlgn1 NLGN1 Membrane protein, integral Q99K10 192167 3|3 A3 mouse T739-p 30318201 CSPQRTTtNDLTHAP intracellular localization 24336150 1 1 0 NL-1 mediated synaptogenesis, surface expression +MAPK1 ERK2 EC 2.7.11.24; KINASE; Kinase, protein; Protein kinase, CMGC; Protein kinase, Ser/Thr (non-receptor) P28482 5594 22q11.22 human T190-p 3949250 FLTEYVAtRWYRAPE Pkinase molecular association, regulation; protein conformation; enzymatic activity, induced G-beta 1(INDUCES) 19060905 4 17 17 +Musk MUSK EC 2.7.10.1; KINASE; Kinase, protein; Membrane protein, integral; Protein kinase, TK; Protein kinase, tyrosine (receptor) Q62838 rat Y553-p 2848304 RLHPNPMyQRMPLLL phosphorylation; enzymatic activity, induced 10619845 2 3 0 promotes MuSK phosphorylation; promotes AChRb clustering and phosphorylation +Kif13b KIF13B Microtubule-binding; Motor Q70AM4 305967 15p12 rat T506-p 27145806 PEGQVMLtPQKNTRT FHA molecular association, regulation TRPV1(INDUCES) 23077056 1 0 0 Phosphorylation at T506 is important for TRPV1 membrane trafficking +BARD1 BARD1 EC 6.3.2.-; EC 6.3.2.19; Ligase; UBIQUITIN LIGASE; Ubiquitin conjugating system; Ubiquitin ligase Q99728 580 2q35 human S391-p 455774 SDEFISLsPGTPPST cell cycle regulation 15855157 1 8 0 resistance to genotoxic stress (mitomycin C) +NR1I2 PXR DNA-binding; Nuclear receptor O75469 8856 3q13.33 human T290-p 25682902 LCQLRFNtVFNAETG Hormone_recep molecular association, regulation; intracellular localization transcription, inhibited HSP90A(INDUCES); DNAJC7(INDUCES) 22829544; 25074870 2 0 0 +VHL VHL Tumor suppressor; UBIQUITIN LIGASE; Ubiquitin ligase P40337 7428 3p25.3 human S80-p 50792657 QVIFCNRsPRVVLPV VHL protein degradation; molecular association, regulation; ubiquitination carcinogenesis, induced; cell motility, induced; cell growth, induced PIN1(INDUCES) 36813923 1 2 0 +PIK3R1 PIK3R1 KINASE; Kinase, lipid; Motility/polarity/chemotaxis P27986 5295 5q13.1 human S83-p 471075 YIGRKKIsPPTPKPR protein degradation; molecular association, regulation; intracellular localization; phosphorylation carcinogenesis, induced; cell growth, induced; apoptosis, inhibited; signaling pathway regulation 14-3-3 zeta(INDUCES) 21743495 3 1 1 induces phosphorylation of Akt and degradation of p53, regulates PI3k/Akt pathway +VIL1 Villin Actin-binding; Motility/polarity/chemotaxis P09327 7429 2q35 human T206-p 15428881 DQERGGRtYVGVVDG Gelsolin cytoskeletal reorganization 29074568 1 1 1 membrane fusion; upon membrane fusion with Sendai virosomes +HSP90AA1 HSP90A Chaperone; Heat shock protein P07900 3320 14q32.31 human T603-p 12078914 PCCIVTStYGWTANM HSP90 molecular association, regulation PKCG(DISRUPTS) 24117238 1 0 8 PKC? phosphorylation of chaperone Hsp90? triggers its own release from the Hsp90? chaperone machinery. +Ppp1r14a PPP1R14A Inhibitor; Protein phosphatase, regulatory subunit Q99MC0 114004 1q21 rat T38-p 449098 QKRHARVtVKYDRRE PP1_inhibitor activity, inhibited; phosphorylation 12359219 29 0 0 upregulates the inhibition on PP1delta activity +Znrf1 ZNRF1 EC 6.3.2.-; EC 6.3.2.19; Ligase; UBIQUITIN LIGASE; Ubiquitin conjugating system; Ubiquitin ligase Q91V17 170737 8|8 E1 mouse Y103-p 479016 TYAHGNGyQETGGGH ubiquitination; enzymatic activity, induced apoptosis, induced 26572622 2 2 38 ZNFR1-dependent Akt ubiquitination, Wallerian degeneration +FAM83G FAM83G A6ND36 644815 17p11.2 human S356-p 3147942 YALVKAKsVDEIAKI phosphorylation apoptosis, induced 32570757 1 17 0 decreases HSP27 phosphorylation +UNC119 UNC119 Adaptor/scaffold Q13432 9094 17q11.2 human Y194-p 1869344407 KNTCEHIyDFPPLSE GMP_PDE_delta molecular association, regulation signaling pathway regulation KRas iso2(INDUCES) 32554467 1 0 0 UNC119A-KRAS-RASSF6-MDM2-p53 pathway +Star STAR Carrier; Lipid-binding; Mitochondrial P51557 20845 8 A2|8 14.17 cM mouse S194-p 450442 RCTKRRGsTCVLAGM START activity, induced; molecular association, regulation signaling pathway regulation 14-3-3 gamma(INDUCES) 22427666; 22681886; 24850413 9 1 0 +CDK5R2 CDK5R2 Protein kinase, regulatory subunit Q13319 8941 2q35 human S8-p 15499459 MGTVLSLsPASSAKG intracellular localization 22467861 1 0 1 CDK5R2 S8 in its unphosphorylated form accumulates at the perinuclear region and T84 plays a role in the nuclear localization of CDK5R2. +WRN WRN Cell cycle regulation; DNA repair, damage; DNA-binding; EC 3.6.4.12; Helicase; Nucleolus Q14191 7486 8p12 human S1141-p 481875 PEKAYSSsQPVISAQ protein degradation; molecular association, regulation; ubiquitination cell cycle regulation; DNA repair, induced DNA(INDUCES) 26695548 3 3 0 WRN replication at S1141 modulates its dissociation from DSBs during replication stress and prevents chromosome breaks +Pln PLB Inhibitor; Membrane protein, integral P61016 64672 20q11 rat T17-p 448115 SAIRRAStIEMPQQA Phospholamban activity, induced 12355181; 21447388 75 12 63 induce calcium uptake +ARHGEF7 ARHGEF7 iso1 GEF; GEF, Rac/Rho; Motility/polarity/chemotaxis Q14155-1 8874 13q34 human Y442-p 3753309 PAPLTPAyHTLPHPS molecular association, regulation carcinogenesis, induced; cell motility, induced; cell motility, altered DYN2(INDUCES); GIT1(DISRUPTS) 20375009; 34582006 3 0 4 +Grm8 mGluR8 GPCR, family 3; Membrane protein, integral; Membrane protein, multi-pass; Receptor, GPCR P47743 14823 6|6 A3.1-A3.2 mouse K882-sm 3726908 DRPNGEVkSELCESL signaling pathway regulation 16144832 2 0 0 GPCR signaling +CASP7 CASP7 Apoptosis; EC 3.4.22.60; Endoplasmic reticulum; Mitochondrial; Protease P55210 840 10q25.3 human T173-p 20473606 FRGDRCKtLLEKPKL Peptidase_C14 activity, inhibited apoptosis, inhibited 21555521 2 0 0 caspase7 cleavage supressed +ELAVL1 HuR RNA-binding Q15717 1994 19p13.2 human S100-p 474553 VSYARPSsEVIKDAN protein degradation; molecular association, regulation RNA splicing, induced; translation, induced; RNA stability, altered RNA(INDUCES); RNA(DISRUPTS) 17317627; 21745814; 24865968; 32929216; 36968077 5 1 1 +CSF1R CSFR EC 2.7.10.1; KINASE; Kinase, protein; Membrane protein, integral; Oncoprotein; Protein kinase, TK; Protein kinase, tyrosine (receptor) P07333 1436 5q32 human Y708-p 451528 NIHLEKKyVRRDSGF PK_Tyr_Ser-Thr activity, induced; molecular association, regulation STAT1(INDUCES) 9000134 12 0 0 +PRKDC DNAPK DNA repair, damage; EC 2.7.11.1; KINASE; Kinase, protein; Nucleolus; Protein kinase, Ser/Thr (non-receptor); Protein kinase, atypical P78527 5591 8q11.21 human T4102-p 1881979000 ESGLSEEtQVKCLMD molecular association, regulation; phosphorylation; enzymatic activity, induced DNA repair, induced Ku80(INDUCES); Ku70(INDUCES) DNA(DISRUPTS) 37309889 1 0 0 induces H2AX and TIF1B phosphorylation +ATAT1 ATAT1 ACETYLTRANSFERASE; Acetyltransferase; EC 2.3.1.108 Q5SQI0 79969 6p21.33 human S315-p 4761832 LAADPGGsPAQRRRT molecular association, regulation; intracellular localization 14-3-3 beta(INDUCES); 14-3-3 zeta(INDUCES); 14-3-3 epsilon(INDUCES); 14-3-3 gamma(INDUCES) 36222836 1 21 10 +Prkaa2 AMPKA2 Autophagy; EC 2.7.11.1; EC 2.7.11.27; EC 2.7.11.31; KINASE; Kinase, protein; Protein kinase, CAMK; Protein kinase, Ser/Thr (non-receptor) Q09137 78975 5q34 rat T172-p 448026 SDGEFLRtSCGSPNY Pkinase enzymatic activity, induced 10642499; 12015362; 17253964; 33848515 220 13 33 +LMNA lamin A/C Cytoskeletal P02545 4000 1q22 human S657-p 4661905 NSSPRTQsPQNCSIM activity, induced; intracellular localization 18815303 1 2 0 nuclear lamin disassemby +MAVS MAVS Adaptor/scaffold; Membrane protein, integral Q7Z434 57506 20p13 human S329-gl 1872691005 VPSKLPTsSKPPGAV phosphorylation 31461653 1 1 0 positively regulates phosphorylation of S442 (data from MAVS 7A mutant) +PDGFRB PDGFRB EC 2.7.10.1; KINASE; Kinase, protein; Membrane protein, integral; Oncoprotein; Protein kinase, TK; Protein kinase, tyrosine (receptor) P09619 5159 5q32 human Y934-p 447518 AHASDEIyEIMQKCW PK_Tyr_Ser-Thr enzymatic activity, induced cell motility, altered 19275932 1 2 1 in vitro +TRAF6 TRAF6 EC 6.3.2.-; Ligase; UBIQUITIN LIGASE; Ubiquitin conjugating system; Ubiquitin ligase Q9Y4K3 7189 11p12 human K124-ub 486279 LFPDNFAkREILSLM protein degradation; molecular association, regulation; ubiquitination; phosphorylation cell differentiation, induced; transcription, induced; signaling pathway regulation UBL4A(INDUCES) 17135271; 19825828; 31451677 3 1 0 UBL4A promotes K63-linked ubiquitination of TRAF6; induces IKB phosphorylation and degradation, thus inducing NF-kB signaling; activation of NFkB and IKK, signaling in osteoclast differentiation, induces NEMO ubiquitination +IRF3 IRF3 DNA-binding; Transcription factor Q14653 3661 19q13.33 human S188-p 30312501 PFPNLGPsENPLKRL molecular association, regulation transcription, inhibited IRF7(INDUCES) 24275658 1 0 0 Formation of IRF3:IRF7 dimers +STAT2 STAT2 DNA-binding; Transcription factor P52630 6773 12q13.3 human S287-p 27259020 KGLSCLVsYQDDPLT STAT_alpha molecular association, regulation; intracellular localization cell growth, inhibited; transcription, inhibited DNA(DISRUPTS) 23139419 1 1 0 phosphorylation limits nuclear translocalization +SP7 osterix C2H2-type zinc finger protein; DNA-binding; Transcription factor Q8TDD2 121340 12q13.13 human K230-ub 31914105 VLPQDVYkPKAVGNS protein degradation cell differentiation, inhibited; transcription, inhibited 23457570 1 0 0 +Ackr3 CMKOR1 GPCR, family 1; Membrane protein, integral; Membrane protein, multi-pass; Receptor, GPCR P56485 12778 1 D|1 45.28 cM mouse S350-p 4709309 LIDASRVsETEYSAL protein degradation endocytosis, induced 30726732 1 9 0 promotes endocytosis and scavenging of CXCL12 and induced degradation of CXCR4 +AXIN1 axin 1 iso2 Adaptor/scaffold; Tumor suppressor O15169-2 8312 16p13.3 human K821-ub 40212802 FEEKIIGkVEKVD__ DIX molecular association, regulation signaling pathway regulation LRP5(DISRUPTS); LRP6(DISRUPTS) 23959799 1 0 0 regulates Wnt/beta-catenin signaling, inhibits LRP6 phosphorylation +HSF1 HSF1 DNA-binding; Transcription factor Q00613 3297 8q24.3 human K118-ac 31953303 LLENIKRkVTSVSTL HSF_DNA-bind activity, inhibited transcription, inhibited 24581496 1 1 0 +NFAT5 NFAT5 Transcription factor O94916 10725 16q22.1 human Y143-p 12127405 PKRHTVLyISPPPED activity, induced; molecular association, regulation; intracellular localization transcription, induced; transcription, altered PLCG1(INDUCES) 20080774; 20351292; 20585028; 30190682 5 1 0 +OTUB1 OTUB1 DEUBIQUITINASE; EC 3.4.19.12; Protease; Ubiquitin conjugating system; Ubiquitin-specific protease Q96FW1 55611 11q13.1 human K71-ub 4954019 DDNIYQQkIKDLHKK Peptidase_C65 enzymatic activity, induced 32842143 1 9 41 K71R mutant failed to deubiquitinate MAF +PPARG PPAR-gamma DNA-binding; Nuclear receptor; Transcription factor P37231 5468 3p25.2 human K382-ac 1881289200 FMTREFLkSLRKPFG transcription, altered 33955199 1 0 0 affects lipid accumulation in adipocytes, PPAR-gamma K382Q mutant overexpression led to the reduced expression of several PPAR-gamma target genes +MYH10 MYH10 Motility/polarity/chemotaxis; Motor P35580 4628 17p13.1 human S1939-p 3189934 GPISFSSsRSGRRQL cytoskeletal reorganization 25869664 1 18 2 poorly defined actomyosin bundles distributed throughout the cell +EZH2 EZH2 EC 2.1.1.43; METHYLTRANSFERASE; Methyltransferase; Methyltransferase, protein lysine Q15910 2146 7q36.1 human T416-p 10417699 EANSRCQtPIKMKPN molecular association, regulation; phosphorylation carcinogenesis, induced; cell motility, induced; cell growth, induced; transcription, induced; transcription, inhibited NIPP-1(INDUCES) 23241245; 26279746; 32368395 5 7 7 inhibition of EZH2 activity(dephosphorylation) causes CDK2 phosphorylation +SLC9A1 NHE1 Membrane protein, integral; Membrane protein, multi-pass; Motility/polarity/chemotaxis; Transporter; Transporter, SLC family P19634 6548 1p36.11 human S766-p 18262072 DGGIMMRsKETSSPG activity, induced 23678047 2 2 0 +CLIC1 CLIC1 Channel, chloride; Membrane protein, integral; Nuclear envelope O00299 1192 6p21.33 human K131-ac 466245 ALNDNLEkGLLKALK GST_C_2 protein stabilization; ubiquitination carcinogenesis, induced; cell motility, induced; cell growth, induced 33469837 1 5 3 stabilizes CLIC1, inhibits ubiquitylation and degradation, K131R overexpression induces cancer cell proliferation, migration and invasion, and in vivo tumorigenesis +Fus hnRNP P2 DNA-binding; Nuclear receptor co-regulator; Oncoprotein; RNA splicing; RNA-binding; SUMO LIGASE P56959 233908 7|7 F3 mouse Y297-p 1869633700 TIESVADyFKQIGII RRM_1 intracellular localization 32678881 1 0 0 Induce fibrotic signaling +PHF2 PHF2 DEMETHYLASE; Demethylase; EC 1.14.11.-; Nucleolus O75151 5253 9q22.31 human S954-p 20936501 QKSKKKKsAKRKLTP molecular association, regulation transcription, induced Mrf-2(INDUCES) DNA(INDUCES) 21532585 1 0 0 demethylation of Mrf-2 K336, complex is then targeted to promoters and removes repressive H3K9m2 +Yy1 YY1 C2H2-type zinc finger protein; Cell development/differentiation; Transcription factor Q00899 22632 12 F1|12 59.58 cM mouse K393-ac 1881842001 PFDGCNKkFAQSTNL molecular association, regulation transcription, induced DNA(DISRUPTS) 35024765 1 1 0 +Insr INSR EC 2.7.10.1; KINASE; Kinase, protein; Membrane protein, integral; Protein kinase, TK; Protein kinase, tyrosine (receptor) P15208 16337 8 A1.1|8 1.82 cM mouse T1177-p 14574883 MTRDIYEtDYYRKGG PK_Tyr_Ser-Thr enzymatic activity, inhibited; phosphorylation signaling pathway regulation 33411692 1 4 52 inhibits PDE3B activity, induces PKA activity, induces phosphorylation of perilipin, HSL, and ATGL, leads to insulin resistance +NOXA1 NOXA1 Activator Q86UR1 10811 9q34.3 human S282-p 12570900 VGKQAPLsPGLPAMG molecular association, regulation RAC1(DISRUPTS); NOX1(DISRUPTS) 20110267 1 0 0 prevents hyperactivation of NOX1 +Kcnk10 TREK-2 Channel, potassium; Membrane protein, integral; Membrane protein, multi-pass Q9JIS4 65272 6q32 rat S326-p 465529 GDWLRVLsKKTKEEV activity, inhibited 16672694; 17540699 2 0 0 relative channel activity reduced in S326D and S359D mutants; shift of gating modes; inhibition mediated by ACh +UPF1 RENT1 C2H2-type zinc finger protein; EC 3.6.1.-; EC 3.6.4.-; Hydrolase; RNA-binding Q92900 5976 19p13.11 human S1107-p 456314 SQIDVALsQDSTYQG molecular association, regulation RNA stability, inhibited SMG7(INDUCES); SMG5(INDUCES) 21965535; 23826386 5 51 45 regulates nonsense-mediated RNA decay, phosphorylation blocked by MARVELD1; important for NMD (nonsense-mediated mRNA decay); as apart of SMD-5:SMG-7 complex binding +Golga3 GOLGA3 Vesicle P55937 269682 5 F|5 53.36 cM mouse S385-p 478659 EVRSRRDsICSSVSM apoptosis, altered 17888676 1 8 28 protected against Brefeldin-A-induced apoptosis, but not Fas-mediated apoptosis. +Gria2 GluR2 Channel, calcium; Channel, ligand-gated; Membrane protein, integral; Membrane protein, multi-pass P19491 29627 2q33 rat Y876-p 452173 YKEGYNVyGIESVKI receptor internalization, induced; molecular association, regulation; receptor internalization, altered neural plasticity IQSEC1(INDUCES) 14976558; 15240807; 20547133; 33798429 9 5 109 +HSP90AA1 HSP90A Chaperone; Heat shock protein P07900 3320 14q32.31 human K407-ac 11315724 REMLQQSkILKVIRK HSP90 molecular association, regulation apoptosis, induced TSC1(INDUCES) 31645902 1 5 0 +Rasgrf1 RASGRF1 GEF; GEF, Ras P28818 192213 8q31 rat S611-p 18710207 QMIKSDAsLYCDDVD protein degradation 21382555 1 1 0 +SPP1 osteopontin Secreted; Secreted, signal peptide P10451 6696 4q22.1 human S120-p 455737 DTDDSHQsDESHHSD Osteopontin molecular association, regulation; activity, inhibited Other(INDUCES) 19775205 1 5 0 peptide with phosphorylated S117, S120, S123, S126 and S129 has increased binding to hydroxyapatite, and inhibits bone mineralization in vivo and in vitro +TRIM24 TRIM24 EC 2.3.2.27; KINASE; Kinase, protein; Nuclear receptor co-regulator; Protein kinase, atypical; Transcription, coactivator/corepressor; Tumor suppressor; UBIQUITIN LIGASE; Ubiquitin conjugating system; Ubiquitin ligase O15164 8805 7q33-q34 human S768-p 481699 TSLLLNSsQSSTSEE protein degradation; molecular association, regulation; phosphorylation DNA repair, induced MRE11A(INDUCES); p53(DISRUPTS) DNA(INDUCES) 24820418; 36550358 2 4 2 induces H2AX phosphorylation +HINT1 HINT1 Cytoskeletal; EC 3.-.-.-; Hydrolase P49773 3094 5q23.3 human K30-ac 11320683 IRKEIPAkIIFEDDR HIT molecular association, regulation carcinogenesis, induced; cell growth, induced CTNNB1(DISRUPTS); MITF(INDUCES) 32636443 1 7 0 +ATXN10 ataxin-10 Cell development/differentiation Q9UBB4 25814 22q13.31 human S77-p 21514207 QVENLASsLQLITEC protein degradation; ubiquitination cell cycle regulation 21857149 2 1 0 required for cytokinesis +Appl1 APPL Adaptor/scaffold; Nuclear receptor co-regulator ENSRNOP00000018413 rat S705-p 56689902 EEGKKREsEA_____ activity, induced; molecular association, regulation PSD-95(INDUCES) 27300007 1 0 0 synaptic activity +RANGAP1 RANGAP1 GAP; GAP, Ras P46060 5905 22q13.2 human S358-p 458865 AKVLASLsDDEDEEE molecular association, regulation RAN(INDUCES); RANBP1(INDUCES) 16428860 1 3 0 +TBK1 TBK1 EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, Other; Protein kinase, Ser/Thr (non-receptor) Q9UHD2 29110 12q14.2 human R228-me 1881361503 FRPFEGPrRNKEVMY enzymatic activity, induced 34551290 1 0 0 TBK1 aggregation, PRMT1 positively regulates antiviral immune responses, and promotes cellular innate antiviral signaling +Nr4a1 Nur77 Apoptosis; DNA-binding; Nuclear receptor P12813 15370 15|15 F1 mouse S344-p 451513 KEVVRTDsLKGRRGR transcription, altered; signaling pathway regulation 35363898 2 2 0 regulates the Nur77? FGF21 pathway +BRAF BRAF EC 2.7.11.1; KINASE; Kinase, protein; Oncoprotein; Protein kinase, Ser/Thr (non-receptor); Protein kinase, TKL Q04982 396239 chicken S486-p 447804 KTLGRRDsSDDWEIP enzymatic activity, induced 16702958 15 44 87 important for cell differentiation +FOXA2 FOXA2 DNA-binding; Transcription factor Q9Y261 3170 20p11.21 human T156-p 4911901 KTYRRSYtHAKPPYS Forkhead_N intracellular localization transcription, altered 14500912 2 0 0 +PPME1 PPME1 DEMETHYLASE; EC 3.1.1.89; Hydrolase; Motility/polarity/chemotaxis; Protein phosphatase, regulatory subunit Q9Y570 51400 11q13.4 human S15-p 476688 MHLGRLPsRPPLPGS enzymatic activity, induced 24841198 2 10 8 +VDAC1 VDAC1 Channel, misc.; Membrane protein, integral; Mitochondrial P21796 7416 5q31.1 human S13-p 479874 TYADLGKsARDVFTK Porin_3 protein stabilization apoptosis, induced 18381814; 25296756 2 3 0 +GTF2B GTF2B ACETYLTRANSFERASE; Acetyltransferase; Nuclear receptor co-regulator; Transcription factor Q00403 2959 1p22.2 human K238-ac 458997 AATHIARkAVELDLV TFIIB molecular association, regulation transcription, altered GTF2F2(INDUCES) 12931194 1 1 0 +Pdpn PDPN Membrane protein, integral Q62011 14726 4|4 E1 mouse S167-p 36491600 IVVMKKIsGRFSP__ Podoplanin cytoskeletal reorganization 25341788 1 0 0 contraction +ELK1 ELK1 DNA-binding; Transcription factor P19419 2002 Xp11.23 human S383-p 447872 IHFWSTLsPIAPRSP activity, induced; molecular association, regulation; intracellular localization; protein conformation carcinogenesis, induced; apoptosis, altered; cell growth, induced; transcription, induced; transcription, altered AurA(INDUCES) DNA(INDUCES) 11145955; 12887893; 20727996; 21258408; 21730285; 23322625; 32034306; 34497368; 8262053; 9130707 45 1 0 +HNF4A HNF4 alpha DNA-binding; Nuclear receptor; Transcription factor P41235 3172 20q13.12 human Y286-p 22996302 LQIDDNEyAYLKAII Hormone_recep protein degradation; intracellular localization; phosphorylation transcription, inhibited 22308320 2 1 0 reduced nuclear localization and protein stability; multistep phosphorylation by Src, phosphorylating Y23 first, which interacts with the Src SH2 domain, followed by phosphorylation of Y286, Y288 +BIRC5 Survivin Apoptosis O15392 332 17q25.3 human T117-p 450947 KNKIAKEtNNKKKEF molecular association, regulation; intracellular localization cell cycle regulation INCENP(INDUCES) 14610074; 17457057 2 0 0 +Ptk2 FAK EC 2.7.10.2; KINASE; Kinase, protein; Protein kinase, TK; Protein kinase, tyrosine (non-receptor) O35346 25614 7q34 rat Y928-p 447966 DRSNDKVyENVTGLV Focal_AT molecular association, regulation; intracellular localization cell motility, induced; cytoskeletal reorganization; signaling pathway regulation PXN(DISRUPTS) 21660950; 25391654 104 17 427 regulates Paxillin localization at FAs; focal adhesion inhibition/dissociation; integrin Rac1-NADPH oxidase signaling +DVL2 DVL2 Adaptor/scaffold; Motility/polarity/chemotaxis O14641 1856 17p13.1 human K343-ub 12338464 VLRDIVHkPGPIVLT PDZ molecular association, regulation; intracellular localization cell motility, induced; signaling pathway regulation Cofilin-1(INDUCES); VANGL1(INDUCES) 31340145 1 6 3 DVL2 variant with all encoded lysine residues mutated to arginine is sufficient to restore WNT activation +GATA1 GATA1 DNA-binding; Transcription factor P15976 2623 Xp11.23 human K246-ac 459077 RPLIRPKkRLIVSKR molecular association, regulation transcription, altered DNA(INDUCES) 16888089 4 0 0 +CAMK2A CAMK2A iso2 EC 2.7.11.17; KINASE; Kinase, protein; Protein kinase, CAMK; Protein kinase, Ser/Thr (non-receptor) Q9UQM7-2 815 5q32 human T286-p 447797 SCMHRQEtVDCLKKF molecular association, regulation; intracellular localization; enzymatic activity, induced NMDAR2B(INDUCES) 28636948 155 34 72 regulates LTP, fear memory, spatial learning +Cyp2e1 CYP2E1 EC 1.14.13.n7; Endoplasmic reticulum; Lipid Metabolism - arachidonic acid; Lipid Metabolism - linoleic acid; Mitochondrial; Oxidoreductase; Xenobiotic Metabolism - drug metabolism - cytochrome P450; Xenobiotic Metabolism - metabolism by cytochrome P450 P05182 25086 1q41 rat S129-p 455561 WKDVRRFsLSILRDW p450 molecular association, regulation HSP70(INDUCES) 12191992 2 7 1 +Nrip1 RIP140 Nuclear receptor co-regulator; Transcription, coactivator/corepressor Q8CBD1 268903 16|16 C3.1 mouse Y436-p 25234801 SSGDESSySNCVPID NRIP1_repr_2 protein degradation; ubiquitination 22388040 1 0 1 regulates inflamatory responses and contributes to endotoxin tolerance +Ric8a RIC8A GEF; GEF, misc. NP_001093990 293614 1q41 rat S523-p 3213324 TMEGQLSsDPDSDPD molecular association, regulation G-alpha i1(INDUCES) 29844055 1 5 0 G-alpha subunit guanine nucleotide exchange; G-alpha subunit folding +Nlrp3 NLRP3 Inhibitor Q8R4B8 216799 11|11 B1.3 mouse S291-p 57761902 CKILRKPsRILFLMD NACHT activity, induced; ubiquitination 27692610; 28716882 4 2 0 activate the NLRP3 iflammasome; inhibits NLRP3 inflammasome activation +Prkaa1 AMPKA1 Autophagy; EC 2.7.11.1; EC 2.7.11.26; EC 2.7.11.27; EC 2.7.11.31; KINASE; Kinase, protein; Protein kinase, CAMK; Protein kinase, Ser/Thr (non-receptor) Q5EG47 105787 15|15 A1 mouse T388-p 7712505 ETPRARHtLDELNPQ autophagy, induced 35256937 2 4 2 +PPP2R5D PPP2R5D Motility/polarity/chemotaxis; PHOSPHATASE; Protein phosphatase, regulatory subunit Q14738 5528 6p21.1 human S60-p 457388 PSSNKRPsNSTPPPT molecular association, regulation; phosphorylation cell cycle regulation PPP2CA(INDUCES) 17110335 5 0 0 enhances dephosphorylation of Cdc25C +Pi4k2a PI4K2A EC 2.7.1.67; Kinase, lipid; Motility/polarity/chemotaxis Q2TBE6 84095 19 C3|19 35.74 cM mouse S5-p 2022753 ___MDETsPLVSPER protein degradation; molecular association, regulation; intracellular localization LAMP1(INDUCES); AP3D1(INDUCES) 25083612 2 12 0 Regulates the lysosomal degradation +BLNK BLNK Adaptor/scaffold Q9YGC1 395733 chicken S170-p 7603529 LPRPKKPsLPSPAAK transcription, altered 19372136 1 1 0 +INPP5D SHIP iso2 EC 3.1.3.86; Motility/polarity/chemotaxis; Phosphatase, lipid Q92835-2 3635 2q37.1 human Y914-p 450030 TEIINPNyMGVGPFG intracellular localization 29852247 3 9 175 nucleocytoplasmic shuttling (A mutants show accumulation in nucleus) +Mknk2 Mnk2 EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, CAMK; Protein kinase, Ser/Thr (non-receptor); Translation Q8CDB0 17347 10|10 C1 mouse T379-p 447642 APENTLPtPLVLQRN enzymatic activity, induced 11154262 1 1 0 +Dnm1l DRP1 Apoptosis; EC 3.6.5.5; Endoplasmic reticulum; Hydrolase; Microtubule-binding; Mitochondrial; Motor O35303 114114 11q23 rat S635-p 454690 PIPIMPAsPQKGHAV activity, induced; intracellular localization cell cycle regulation; apoptosis, induced 17301055; 23798729; 29704468; 33603953; 36315519; 36805606 132 78 114 +PFN1 profilin 1 Actin-binding; Cytoskeletal; Motility/polarity/chemotaxis P07737 5216 17p13.2 human Y60-p 464066 GKDRSSFyVNGLTLG Profilin molecular association, regulation ACTA1(INDUCES) 18573880 1 3 73 +EIF2AK2 PKR EC 2.7.10.2; EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, Other; Protein kinase, Ser/Thr (non-receptor); Protein kinase, tyrosine (non-receptor); Translation P19525 5610 2p22.2 human T90-p 3181643 SPLLLTTtNSSEGLS enzymatic activity, induced 11152499 1 1 0 +DDR1 DDR1 EC 2.7.10.1; KINASE; Kinase, protein; Membrane protein, integral; Protein kinase, TK; Protein kinase, tyrosine (receptor) Q08345 780 6p21.33 human Y797-p 457958 NLYAGDYyRVQGRAV PK_Tyr_Ser-Thr activity, induced 24509848 0 11 303 phosphorylated in the N211QDDR1 mutant +MCM3 MCM3 DNA replication; EC 3.6.4.12 P25205 4172 6p12.2 human S112-p 2840507 SFGSKHVsPRTLTSC MCM_OB molecular association, regulation MCM7(INDUCES) 21658608 3 0 0 +Foxp1 FOXP1 C2H2-type zinc finger protein; Cell cycle regulation; DNA-binding; Transcription factor Q498D1 297480 4q34 rat K670-sm 610814010 AVHPIHVkEEPLDPE molecular association, regulation transcription, inhibited; signaling pathway regulation CTBP1(INDUCES) 28408745 2 1 0 regulates neuronal morphogenesis and development +IQGAP1 IQGAP1 GAP; GAP, Ras; Motility/polarity/chemotaxis P46940 8826 15q26.1 human K1475-ub 12289715 ELGTVDPkNKYQELI RasGAP_C activity, induced; molecular association, regulation cell motility, induced CDC42(INDUCES); RAC1(INDUCES) 32094223 1 4 9 K165R, K175R mutant binding compared to WT, ubiquitination of the GRD likely blocks CDC42 binding; 6KR mutant compared to WT +Caskin1 CASKIN1 Adaptor/scaffold Q8VHK2 140722 10q12 rat Y336-p 4274896 TGNDRVGyFPSSLGE SH3_2 protein conformation 23181695 1 1 0 Phosphorylation leads to structural changes in the SH3 domain. +CALCOCO1 CALCOCO1 Nuclear receptor co-regulator Q9P1Z2 57658 12q13.13 human K29-sm 2887214 RTYIPNTkVECHYTL SKICH transcription, altered 18218142 1 0 0 differential regulation of LEF1 and ER transcription +NUDC NUDC Cell cycle regulation; Cytoskeletal Q9Y266 10726 1p36.11 human T40-p 11164887 FSFLRRKtDFFIGGE Nudc_N cell cycle regulation 27074040 1 0 1 regulates cytokinesis +CAMK2G CAMK2G EC 2.7.11.17; KINASE; Kinase, protein; Protein kinase, CAMK; Protein kinase, Ser/Thr (non-receptor) Q13555 818 10q22.2 human T287-p 467596 SMMHRQEtVECLRKF protein stabilization; intracellular localization; enzymatic activity, induced 19884317; 25303525 6 41 235 induces translocation of HDAC4 and 5; cotransport of Ca2+/CaM to the nucleus along with CaMK2G +EIF4EBP1 4E-BP1 Translation; Translation initiation Q13541 1978 8p11.23 human T46-p 447496 GGTLFSTtPGGTRII eIF_4EBP molecular association, regulation; activity, inhibited; phosphorylation carcinogenesis, induced; carcinogenesis, inhibited; cell growth, inhibited; signaling pathway regulation; translation, altered; autophagy, induced; cell growth, induced; apoptosis, inhibited; autophagy, inhibited; translation, induced 4E-BP1(DISRUPTS); mTOR(DISRUPTS); EIF4E(DISRUPTS) 11799119; 12588975; 15051500; 19036825; 21602434; 21734039; 21750219; 21914810; 22071574; 23542178; 23584478; 24247720; 25361081; 32094692; 34546793; 34673774; 35626002; 35864174; 36652560; 36882522; 37264081; 9465032 156 36 91 +H2ac4 H2A.1 DNA-binding C0HKE1 319172 13|13 A3.1 mouse K119-ub 482913 QAVLLPKkTESHHKA Histone_H2A_C molecular association, regulation; ubiquitination; intracellular localization cell cycle regulation; DNA repair, induced; cell growth, inhibited; transcription, induced; transcription, inhibited DNMT3A(INDUCES) DNA(INDUCES) 26272920; 26716510; 26748827; 33986537; 35640597 48 14 146 H2AK119ub1 at the actively transcribed genes marked by H3K4me3 ; H2AK119ub1 was with other modications and worked with H3K27me3 to inhibit transcription. +AKT1 Akt1 EC 2.7.11.1; KINASE; Kinase, protein; Oncoprotein; Protein kinase, AGC; Protein kinase, Ser/Thr (non-receptor) P31749 207 14q32.33 human K140-m3 1879848300 EMEVSLAkPKHRVTM enzymatic activity, induced carcinogenesis, induced; cell motility, induced JMJD2B(INDUCES); JMJD2A(INDUCES); PDK1(INDUCES); TRAF6(INDUCES) 30692625 1 1 0 interaction of Akt1 with TRAF6, and subsequent Akt ubiquitination ; promotes cell growth and glycolysis +CHEK2 Chk2 EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, CAMK; Protein kinase, Ser/Thr (non-receptor); Tumor suppressor O96017 11200 22q12.1 human K520-p 1877735400 AQPSTSRkRPREGEA phosphorylation; enzymatic activity, induced cell cycle regulation Chk2(INDUCES) 31209362 1 0 0 +Nos3 eNOS Amino Acid Metabolism - arginine and proline; EC 1.14.13.39; Oxidoreductase Q62600 24600 4q11 rat T494-p 447885 TGITRKKtFKEVANA enzymatic activity, inhibited 10025949; 17376767; 34389653; 35954193; 36345832 82 2 1 +EIF4B EIF4B RNA-binding; Translation; Translation initiation P23588 1975 12q13.13 human S422-p 451290 RERSRTGsESSQTGT molecular association, regulation; activity, inhibited carcinogenesis, induced; translation, altered; cell growth, induced; cell growth, inhibited; apoptosis, inhibited; translation, induced eIF3-alpha(INDUCES) 15071500; 16763566; 26848623; 33939688; 36882522 11 54 482 +Prkd2 PRKD2 EC 2.7.11.13; KINASE; Kinase, protein; Motility/polarity/chemotaxis; Protein kinase, CAMK; Protein kinase, Ser/Thr (non-receptor) Q8BZ03 101540 7|7 A2 mouse S707-p 449864 ARIIGEKsFRRSVVG Pkinase exocytosis, induced 21527521 5 10 21 in dense granules, platelet aggregation and thrombus formation +ASAP1 DDEF1 GAP; GAP, ARF; Motility/polarity/chemotaxis Q9ULH1 50807 8q24.21-q24.22 human Y312-p 480743 SQSRQGGySMHQLQG molecular association, regulation; intracellular localization GBF1(INDUCES) 29654145 1 1 1 relocalization of ER chaperones +Cacna1c CACNA1C Channel, calcium; Membrane protein, integral; Membrane protein, multi-pass Q01815 12288 6 F1|6 55.86 cM mouse S1487-p 460572 DYLTRDWsILGPHHL Ion_trans activity, induced 20479240 5 1 0 mediates Ca2+ current facilitation +UBAP2L NICE-4 RNA-binding; Ubiquitin conjugating system Q14157 9898 1q21.3 human R187-m2 27280772 GRGGSGRrGGRFSAQ molecular association, regulation 31114027 1 2 1 regulation of stress-granule dynamics by NICE-4 arginine methylation +Anxa2 ANXA2 Calcium-binding; Lipid-binding; Motility/polarity/chemotaxis P07356 12306 9 C|9 38.58 cM mouse S26-p 450879 TPPSAYGsVKPYTNF phosphorylation carcinogenesis, induced; cell growth, induced; autophagy, inhibited; translation, induced; signaling pathway regulation 35257889; 36739096 14 29 100 induces PI3K and mTOR phosphorylation and hence the PI3K-mTOR signaling +AURKB AurB EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, Other; Protein kinase, Ser/Thr (non-receptor) Q96GD4 9212 17p13.1 human K87-ub 21129744 GRPLGKGkFGNVYLA Pkinase intracellular localization; enzymatic activity, induced 35853811 1 6 0 localization of TbRI in the midbody during cell division +Plk4 PLK4 EC 2.7.11.21; KINASE; Kinase, protein; Nucleolus; Protein kinase, Other; Protein kinase, Ser/Thr (non-receptor) Q64702 20873 3|3 B mouse T289-p 12654002 SMDSGHAtLSTTITA protein degradation; ubiquitination 20100909 1 1 0 +CCNE1 CCNE1 Activator; Cell cycle regulation; Nuclear receptor co-regulator P24864 898 19q12 human T77-p 454411 DPCSLIPtPDKEDDD protein degradation; molecular association, regulation FBXW7(INDUCES) 14536078; 15364936; 17434132 8 1 0 +HNRNPA2B1 hnRNP A2/B1 iso2 RNA splicing; RNA-binding; Spliceosome P22626-2 3181 7p15.2 human K305-ub 1877221605 PSNYGPMkSGNFGGS HnRNPA1 protein degradation carcinogenesis, inhibited; cell growth, inhibited 32826868 1 0 0 +BRAF BRAF EC 2.7.11.1; KINASE; Kinase, protein; Oncoprotein; Protein kinase, Ser/Thr (non-receptor); Protein kinase, TKL Q04982 396239 chicken S365-p 450243 GQRDRSSsAPNVHIN molecular association, regulation; enzymatic activity, inhibited 14-3-3 beta(INDUCES) 16702958 9 27 30 +Grin2c NMDAR2C Channel, calcium; Channel, ligand-gated; Membrane protein, integral; Membrane protein, multi-pass Q01098 14813 11 E2|11 80.8 cM mouse S1084-p 7979604 GPRPRHAsLPSSVAE intracellular localization apoptosis, altered 19477150 2 0 0 important for cell survival +TERF2 TRF2 DNA repair, damage; DNA-binding Q15554 7014 16q22.1 human R70-me 10338217 RSSGRARrGRHEPGL cell cycle regulation; cell growth, altered 19596784 1 0 0 +Abi1 Abi-1 Adaptor/scaffold; Motility/polarity/chemotaxis Q8CBW3 11308 2 A3|2 15.18 cM mouse S216-p 3205884 VPNDYMTsPARLGSQ protein stabilization cell differentiation, inhibited; cytoskeletal reorganization 32673396 3 12 32 Regulate epiblast differentiation and polarizations +XPC XPC DNA repair, damage Q01831 7508 3p25.1 human S129-p 14161729 SNEEEEEsENDWEEV molecular association, regulation GTF2H1(INDUCES) 26029824 1 12 0 +Mcl1 MCL1 Apoptosis; Channel, misc.; Inhibitor; Membrane protein, integral; Mitochondrial P97287 17210 3 F2.1|3 40.74 cM mouse K178-ub 10837359 ATGSKDSkPLGEAGA protein degradation; molecular association, regulation; ubiquitination autophagy, induced beclin 1(DISRUPTS) 28053206; 32094511 4 5 27 +TP53 p53 Activator; DNA-binding; Motility/polarity/chemotaxis; Nuclear receptor co-regulator; Transcription factor; Tumor suppressor P04637 7157 17p13.1 human K381-ub 464657 GQSTSRHkKLMFKTE protein degradation; molecular association, regulation; intracellular localization transcription, inhibited ING1(DISRUPTS) 11046142; 17371868; 19927155; 21731648; 31002112 10 0 0 K370/372/373/381/382/386/R mutant shows 613-fold activation of p53; binds unmodified or six multimonoubiquitinated forms of wild-type p53; translocation of p53 from the nucleus to the cytoplasm, promotes EMT in EOC cells +EPB41 EPB41 iso4 Cytoskeletal P11171-4 2035 1p35.3 human S331-p 451158 RTASKRAsRSLDGAA FA molecular association, regulation; protein conformation cytoskeletal reorganization XK(INDUCES); SPTA1(DISRUPTS); DARC(INDUCES); GPC1(INDUCES) 21542582 3 14 0 interactions are induced by phosphorylation of either of the sites +SHC3 SHC3 iso2 Adaptor/scaffold; Motility/polarity/chemotaxis Q92529-2 53358 9q22.1 human Y301-p 451259 PTGEAPTyVNTQQIP activity, induced; molecular association, regulation; phosphorylation transcription, altered DYN1(INDUCES); SOS1(INDUCES); GRB2(INDUCES) 11791173; 16126371 3 0 1 ERK activation +PDE4D PDE4D iso2 EC 3.1.4.53; Nucleotide Metabolism - purine; Phosphodiesterase Q08499-2 5144 5q11.2-q12.1 human S239-p 469621 KKLMHSSsLTNSSIP enzymatic activity, induced 16973330 2 12 6 switches the effect of S579 phosphorylation from inhibition to activation +Nrip1 RIP140 Nuclear receptor co-regulator; Transcription, coactivator/corepressor Q8CBD1 268903 16|16 C3.1 mouse T207-p 455626 GPTLPDVtPNLIRDS NRIP1_repr_1 activity, induced; molecular association, regulation; acetylation; intracellular localization cell differentiation, induced; transcription, inhibited p300(INDUCES) 16093479; 18655826 2 3 0 increases acetylation of RIP140 at K158 and K287 +SMPD1 SMPD1 EC 3.1.4.12; Lipid Metabolism - sphingolipid; Phosphodiesterase P17405 6609 11p15.4 human S510-p 477185 DGNYSGSsHVVLDHE ASMase_C intracellular localization; enzymatic activity, induced apoptosis, induced 17303575; 17698617 2 0 0 +Ifnar2 IFNAR2 Membrane protein, integral; Receptor, cytokine O35664 15976 16 C3.3|16 52.82 cM mouse Y510-p 3063304 DADVGDGyIMR____ phosphorylation signaling pathway regulation 36118237 5 0 0 induces STAT phosphorylation and signaling +KDM3A JMJD1A DEMETHYLASE; Demethylase; EC 1.14.11.-; Nuclear receptor co-regulator; Oxidoreductase Q9Y4C1 55818 2p11.2 human K918-ub 12301471 FASLVQNkTTSDLSK intracellular localization DNA repair, induced; cell growth, induced; transcription, induced 32238799 1 5 11 recruitment of p300 to c-Myc for the expression of DDR genes, resistance of prostate cancer cells to genotoxic stress +TIAM1 TIAM1 GEF; GEF, Rac/Rho; Motility/polarity/chemotaxis; Oncoprotein Q13009 7074 21q22.11 human S60-p 11485305 EVSTRSSsTPSIPQS protein stabilization; molecular association, regulation 14-3-3 beta(INDUCES) 25746002 2 1 0 +Bub1b BUB1B EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, Other; Protein kinase, Ser/Thr (non-receptor); Tumor suppressor Q9Z1S0 12236 2|2 E5 mouse T669-p 484623 IEESREAtHSSGFSR phosphorylation 26028219 5 0 0 decrease CASC5 phosphorylation +RIGI RIGI EC 3.6.4.13; Hydrolase O95786 23586 9p21.1 human T667-p 63044900 ILTGRGKtNQNTGMT Helicase_C molecular association, regulation; activity, inhibited RNA(DISRUPTS) 28132841 1 1 0 +Src Src EC 2.7.10.2; KINASE; Kinase, protein; Oncoprotein; Protein kinase, TK; Protein kinase, tyrosine (non-receptor) P05480 20779 2 H1|2 78.35 cM mouse Y138-p 450213 TGYIPSNyVAPSDSI cell cycle regulation; cell growth, altered 8663329 3 0 0 +DACH1 DACH1 DNA-binding; Motility/polarity/chemotaxis; Transcription factor Q9UI36 1602 13q21.33 human S491-p 4782162 IKERVPDsPSPAPSL intracellular localization; activity, inhibited translation, inhibited 24335958 1 7 0 Repression of Snail 5' UTR-Luc reporter +Tnni3 TNNI3 Actin-binding; Motility/polarity/chemotaxis; Motor P48787 21954 7 A1|7 2.61 cM mouse S43-p 450690 AKKKSKIsASRKLQL activity, induced; activity, inhibited; protein conformation cell motility, altered; cytoskeletal reorganization 12003851; 12181153; 12923217; 14726296; 17010989; 19426736; 20083117; 22527640 24 2 0 slows rate of contraction and relaxation +PHLPP1 PHLPP EC 3.1.3.16; PHOSPHATASE; Protein phosphatase, Ser/Thr (non-receptor); Tumor suppressor O60346 23239 18q21.33 human T451-p 3952371 APGGLQStPGRSGVT cell cycle regulation 33397691 1 2 5 +RMI2 RMI2 DNA replication Q96E14 116028 16p13.13 human S112-p 29606701 MGVVQACsPEPCLQA RMI2 cell cycle regulation 24108125 1 1 0 genome stability +APOBEC3G APOBEC3G EC 3.5.4.-; Hydrolase; RNA processing; RNA-binding Q9HC16 60489 22q13.1 human K303-ub 11956703 AKFISKNkHVSLCIF NAD2 protein degradation 19887642 1 0 0 +Cdkn2a p14ARF SUMO LIGASE; SUMO conjugating system Q64364 12578 4 C4|4 42.15 cM mouse S71-p 50440900 GDDDGQRsRSSSSAQ protein degradation; molecular association, regulation; ubiquitination FBW1B(INDUCES) 26240281 1 0 0 +JUP CTNNG Cytoskeletal; Motility/polarity/chemotaxis P14923 3728 17q21.2 human Y644-p 456973 RNEGTATyAAAVLFR molecular association, regulation transcription, induced CDH1(DISRUPTS); CTNNA1(DISRUPTS); Desmoplakin(INDUCES) 14517306 1 1 29 +CTNNB1 CTNNB1 Actin-binding; Cell adhesion; Motility/polarity/chemotaxis; Nuclear receptor co-regulator; Oncoprotein; Transcription factor P35222 1499 3p22.1 human S191-p 467710 SRHAIMRsPQMVSAI protein stabilization; molecular association, regulation; intracellular localization; protein conformation transcription, induced PIN1(INDUCES) 26740630 5 45 11 nuclear retention +PCYT1A PCYT1A EC 2.7.7.15; Lipid Metabolism - glycerophospholipid; Transferase P49585 5130 3q29 human K57-ub 7761224 EIEVDFSkPYVRVTM protein degradation; molecular association, regulation; intracellular localization KPNA1(DISRUPTS) 19332566 1 2 0 +SUN1 SUN1 Cytoskeletal; Membrane protein, integral O94901 23353 7p22.3 human S55-p 179463700 SPRMSRRsLRLATTA molecular association, regulation NXF1(DISRUPTS) 28831067 1 0 0 mRNA export +XPO5 Exportin-5 Karyopherin; Nuclear export; Nuclear import; RNA-binding Q9HAV4 57510 6p21.1 human S497-p 59179701 GSLCSVFsPSFVQWE Exportin-5 protein conformation 29445125 1 0 0 isomerization of phosphorylated peptide by Pin1 in vitro +CPLX1 CPLX1 Vesicle Q0IIL7 768228 cow S115-p 474557 AAEEEDEsILDTVIK Synaphin molecular association, regulation STX1A(INDUCES) 17266930 2 1 1 SNARE complex summarized by Syntaxin binding. +Tom1l1 Srcasm Adaptor/scaffold Q923U0 71943 11 D|11 55.47 cM mouse S320-p 3177419 SCDLLDLsPIVPVPT molecular association, regulation TOLLIP(INDUCES) 26899482 1 15 0 peripheral localization, ECM degradation and invasion +KCNE1 KCNE1 Channel, potassium; Membrane protein, integral P15382 3753 21q22.12 human S102-p 10349700 VQARVLEsYRSCYVV ISK_Channel activity, induced; receptor internalization, induced; activity, inhibited endocytosis, induced 21699843; 29452158; 32833978; 33373586 5 0 0 induces voltage-gated current and hence activity of TMEM16A; downregulates IKs by stimulating KCNQ1-KCNE1 channel endocytosis +EPHA2 EphA2 EC 2.7.10.1; KINASE; Kinase, protein; Membrane protein, integral; Protein kinase, TK; Protein kinase, tyrosine (receptor) P29317 1969 1p36.13 human Y735-p 473293 KYLANMNyVHRDLAA PK_Tyr_Ser-Thr molecular association, regulation cell differentiation, altered; cell motility, altered PIK3R1(INDUCES) 18387945 1 4 17 +EGLN1 EGLN1 EC 1.14.11.29; Oxidoreductase Q9GZT9 54583 1q42.2 human S136-p 1877121600 AAAGGQGsAVAAEAE enzymatic activity, inhibited signaling pathway regulation 35538889 1 1 0 regulates PHD2/HIFa/hepcidin/ferroportin signalling +FOXC2 FOXC2 Apoptosis; Cell development/differentiation; DNA-binding; Transcription factor Q99958 2303 16q24.1 human S219-p 3210576 VIKSEAAsPALPVIT molecular association, regulation transcription, altered DNA(INDUCES) 23878394 1 18 1 implicated in vascular remodeling in vivo +FOXM1 FOXM1 DNA-binding; Transcription factor Q08050 2305 12p13.33 human K460-sm 31898501 LLPVQTIkEEEIQPG protein degradation; ubiquitination; intracellular localization cell cycle regulation; cell growth, inhibited; transcription, inhibited 24362530 2 2 0 +ARAF ARAF EC 2.7.11.1; KINASE; Kinase, protein; Oncoprotein; Protein kinase, Ser/Thr (non-receptor); Protein kinase, TKL P10398 369 Xp11.3 human S214-p 3180426 LQRIRSTsTPNVHMV enzymatic activity, induced 18662992 1 5 25 +FANCD2 FANCD2 DNA repair, damage Q9BXW9 2177 3p25.3 human T884-p 1871613603 SKTSSSDtLSEEKNS FancD2 molecular association, regulation; ubiquitination; intracellular localization; activity, inhibited cell cycle regulation; DNA repair, inhibited; signaling pathway regulation DNA(DISRUPTS) 31167143 1 1 0 inhibits Fanconi anemia pathway leading to inhibition of DNA repair; 882-898 cluster +LEF1 LEF-1 DNA-binding; Transcription factor Q9UJU2 51176 4q25 human T155-p 11499001 SHAVHPLtPLITYSD CTNNB1_binding activity, induced; molecular association, regulation transcription, induced; signaling pathway regulation; transcription, inhibited HDAC1(DISRUPTS) 12556497; 22373574 3 1 10 Wnt/beta-catenin signalling pathway +Myog myogenin DNA-binding; Transcription factor P12979 17928 1 E4|1 58.18 cM mouse T87-p 451161 VDRRRAAtLREKRRL HLH activity, induced 14966278 1 0 0 affects muscle innervation rates +Pip5k1c PIP5K1C Carbohydrate Metabolism - inositol phosphate; EC 2.7.1.68; Kinase, lipid; Motility/polarity/chemotaxis O70161 18717 10|10 C1 mouse S645-p 457599 DERSWVYsPLHYSAR molecular association, regulation endocytosis, inhibited AP-2 alpha(DISRUPTS) 22243752 2 1 0 +RUNX1 AML1 DNA-binding; Oncoprotein; Transcription factor Q01196 861 21q22.12 human K144-ub 95155310 VGRSGRGkSFTLTIT Runt protein degradation; intracellular localization carcinogenesis, inhibited; cell growth, inhibited; transcription, inhibited 28536267 1 0 0 +RBM25 RBM25 RNA splicing; RNA-binding; Spliceosome P49756 58517 14q24.2 human K77-me 1873076616 DHPGLKAkENDENCG molecular association, regulation SFRS2(DISRUPTS) 28655759 0 1 0 promotes inclusion of alternatively spliced exons +TDG TDG DNA repair, damage; EC 3.2.2.29; Hydrolase; Nuclear receptor co-regulator Q13569 6996 12q23.3 human K330-sm 3144814 DAKKMAVkEEKYDPG molecular association, regulation; protein conformation; enzymatic activity, induced DNA repair, induced; DNA repair, altered DNA(DISRUPTS) 11889051; 15823533; 15959518; 21284855 5 3 0 +HDAC2 HDAC2 DEACETYLASE; Deacetylase; EC 3.5.1.98; Nuclear receptor co-regulator; Transcription, coactivator/corepressor P56519 395635 chicken S407-p 476456 EDPDKRIsIRASDKR molecular association, regulation MBD3(INDUCES); MTA1(INDUCES); HDAC2(INDUCES) 33596269 1 7 4 promotes homodimerization +SAFB SAFB1 DNA-binding; Nuclear receptor co-regulator; RNA-binding Q15424 6294 19p13.3 human K226-m1 58123205 DILGETCkSEPVKEE molecular association, regulation L3MBTL iso4(INDUCES) 23583077 0 1 0 +SDHA SDHA Carbohydrate Metabolism - citrate (TCA) cycle; EC 1.3.5.1; Energy Metabolism - oxidative phosphorylation; Mitochondrial; Oxidoreductase; Tumor suppressor P31040 6389 5p15.33 human K179-ac 461207 AFGGQSLkFGKGGQA FAD_binding_2 enzymatic activity, inhibited 26998524 3 8 8 +SMURF2 SMURF2 EC 6.3.2.-; EC 6.3.2.19; Ligase; UBIQUITIN LIGASE; Ubiquitin conjugating system; Ubiquitin ligase Q9HAU4 64750 17q23.3-q24.1 human R237-m1 56854403 ERRVRSQrHRNYMSR protein degradation 26126536 1 0 0 +Tdg TDG DNA repair, damage; EC 3.2.2.29; Hydrolase; Nuclear receptor co-regulator P56581 21665 10 C1|10 39.72 cM mouse S99-p 11509300 TSKKSGKsTKSKEKQ molecular association, regulation; acetylation DNA repair, induced DNA(INDUCES) 19966277 1 0 0 inhibits acetylation at other sites +MEF2D MEF2D DNA-binding; Transcription factor Q14814 4209 1q22 human S110-p 470517 GEDSLEQsPLLEDKY HJURP_C molecular association, regulation; ubiquitination SKP2(INDUCES) 25733682 1 9 3 +SPAST spastin Cytoskeletal; EC 3.6.4.3; Membrane protein, integral Q9UBP0 6683 2p22.3 human K554-ub 27210454 SDLTALAkDAALGPI AAA_lid_3 protein degradation 33106322 1 1 0 +Dact1 DACT1 Adaptor/scaffold Q8R4A3 59036 12|12 C3 mouse S704-p 1833062500 GDSESSVsEGDFVGE Dapper signaling pathway regulation 31978940 1 0 0 Wnt signaling pathway +KCNA3 Kv1.3 Channel, potassium; Membrane protein, integral; Membrane protein, multi-pass P22001 3738 1p13.3 human Y163-p 3820936 FDAILYYyQSGGRIR BTB_2 activity, inhibited 19166614 1 0 0 +ERBB3 HER3 EC 2.7.10.1; KINASE; Kinase, protein; Membrane protein, integral; Oncoprotein; Protein kinase, TK; Protein kinase, tyrosine (receptor) P21860 2065 12q13.2 human Y1260-p 449860 GTTPDEDyEYMNRQR molecular association, regulation carcinogenesis, induced; cell motility, induced PIK3R2(INDUCES); PIK3R1(INDUCES) 16729043; 21725367 3 0 16 chemotaxis and invasion +WEE1 Wee1 EC 2.7.10.2; KINASE; Kinase, protein; Protein kinase, Other; Protein kinase, Ser/Thr (non-receptor); Protein kinase, tyrosine (non-receptor) P30291 7465 11p15.4 human S121-p 456468 WEEEGFGsSSPVKSP protein degradation; molecular association, regulation BTRC(INDUCES) 16085715 2 0 0 +Itch ITCH EC 6.3.2.-; EC 6.3.2.19; Ligase; UBIQUITIN LIGASE; Ubiquitin conjugating system; Ubiquitin ligase Q8C863 16396 2 H1|2 76.94 cM mouse T222-p 459624 PSRPPPPtPRRPASV protein stabilization; protein conformation 16446428 3 0 0 +MLLT1 MLLT1 Oncoprotein; Transcription regulation Q03111 4298 19p13.3 human S394-p 40666501 SDSDFEPsQNHSQGP molecular association, regulation transcription, inhibited BMI1(INDUCES) 25921070 1 0 0 +Dusp9 DUSP9 EC 3.1.3.16; EC 3.1.3.48; Motility/polarity/chemotaxis; PHOSPHATASE; Protein phosphatase, dual-specificity Q7TNL7 75590 X|X A7.3 mouse S58-p 22694400 LRRLRRGsMSVRSLL Rhodanese molecular association, regulation; enzymatic activity, inhibited signaling pathway regulation ERK2(DISRUPTS); P38A(DISRUPTS) 21908610 1 0 0 regulates MAPK signaling pathway +H4C1 H4 DNA-binding P62805 8359 6p22.2 human K20-me 4145502 GGAKRHRkVLRDNIQ CENP-T_C acetylation 12208845 8 0 0 inhibits K16 acetylation +SCN5A SCN5A Channel, sodium; Membrane protein, integral; Membrane protein, multi-pass Q14524 6331 3p22.2 human S1503-p 9993604 NAMKKLGsKKPQKPI intracellular localization; activity, inhibited 22101522; 32209328 4 1 0 NR decreased current in K1479A SCN5A, but increased INa. Disruption of S1503 site abolished effect on INa.; regulating intracellular Na+channel localization, and the rate of intrcecellular trafficking ; NR increased current, INa +IER3 IEX-1 Apoptosis; Membrane protein, integral P46695 8870 6p21.33 human T18-p 455559 MTILQAPtPAPSTIP apoptosis, inhibited 12356731 1 2 0 +HIPK2 HIPK2 EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, CMGC; Protein kinase, Ser/Thr (non-receptor) Q9H2X6 28996 7q34 human T360-p 8086452 VSKAVCStYLQSRYY Pkinase molecular association, regulation; enzymatic activity, induced apoptosis, induced; signaling pathway regulation ASK1(INDUCES); JNK2(INDUCES) 27321923 1 5 18 HIPK2 and JNK activation +TET2 TET2 EC 1.14.11.n2; Oxidoreductase; Tumor suppressor Q6N021 54790 4q24 human Y1939-p 1870020000 CEKYGPDyVPQKSHG activity, induced; molecular association, regulation cell differentiation, induced; signaling pathway regulation KLF1(INDUCES) 30944118 1 0 0 +AHR AHR DNA-binding; Transcription factor P35869 196 7p21.1 human S693-p 1874101924 PYKSEMDsMPYTQNF protein degradation; ubiquitination autophagy, induced; transcription, induced 34198826 1 0 0 +RAD51 RAD51 DNA repair, damage; Mitochondrial Q06609 5888 15q15.1 human S14-p 23305001 LEANADTsVEEESFG activity, induced; molecular association, regulation; intracellular localization; phosphorylation cell cycle regulation; DNA repair, induced BRCA2(INDUCES) DNA(INDUCES) 22325354; 24835992; 34197606 5 1 0 +UBE2I UBC9 EC 6.3.2.-; EC 6.3.2.19; Ligase; Nuclear receptor co-regulator; SUMO LIGASE; SUMO conjugating system; SUMO ligase; UBIQUITIN LIGASE; Ubiquitin conjugating system; Ubiquitin ligase P63279 7329 16p13.3 human K49-sm 14512106 ECAIPGKkGTPWEGG UQ_con sumoylation; molecular association, regulation signaling pathway regulation RASD2(INDUCES) 20424159; 27501389 2 7 0 TTR specifically modulates general protein SUMOylation; RASD2 enhances sumoylation, induces sumoylation of SP100 +KCNJ2 KCNJ2 Channel, potassium; Membrane protein, integral; Membrane protein, multi-pass P63252 3759 17q24.3 human S425-p 10892807 PRPLRREsEI_____ activity, inhibited 19843922 1 0 0 reduces an inward rectifier current of Kir2.1 V227F +Kcnn4 KCNN4 Channel, potassium; Membrane protein, integral; Membrane protein, multi-pass Q9QYW1 65206 1q21 rat S332-p 452145 KHTRRKDsRAARRHQ CaMBD activity, inhibited Calmodulin(DISRUPTS) 15243742; 25274816 3 0 0 inhibits channel current, inhibits Ca++ influx +ACLY ACLY Carbohydrate Metabolism - citrate (TCA) cycle; EC 2.3.3.8; Lyase; Transferase P53396 47 17q21.2 human K546-ac 11323411 QKFYWGHkEILIPVF CoA_binding protein stabilization; molecular association, regulation; ubiquitination carcinogenesis, induced; cell growth, induced UBR4(INDUCES) 23932781; 31197036 2 3 0 inhibits ubiquitination, high glucose decreases interaction +TNIP1 TNIP1 Transcription regulation Q15025 10318 5q33.1 human S122-p 1880462800 KPPSSGTsSEFEVVT protein degradation; molecular association, regulation; ubiquitination autophagy, induced; transcription, induced LC3B(INDUCES); LC3C(INDUCES); GABARAPL2(INDUCES) 36574265 1 1 0 +NUMB NUMB iso3 Cell development/differentiation P49757-3 8650 14q24.2-q24.3 human S265-p 456490 EQLARQGsFRGFPAL NumbF molecular association, regulation; intracellular localization endocytosis, inhibited AP2A1(DISRUPTS); CDH1(DISRUPTS); CTNND1(DISRUPTS) 21775625 4 18 7 +GRIA1 GluR1 Channel, calcium; Channel, ligand-gated; Membrane protein, integral; Membrane protein, multi-pass P42261 2890 5q33.2 human S834-p 9486201 EFCYKSRsESKRMKG molecular association, regulation; intracellular localization EPB41L1(INDUCES) 19503082 1 0 0 enhances receptor insertion into plasma membrane +DRD2 DRD2 GPCR, family 1; Membrane protein, integral; Membrane protein, multi-pass; Receptor, GPCR P14416 1813 11q23.2 human S229-p 487433 RVNTKRSsRAFRAHL 7tm_1 receptor desensitization, induced 17869243 2 0 0 +Ppargc1a PGC-1 alpha Nuclear receptor co-regulator; Transcription, coactivator/corepressor O70343 19017 5|5 C1 mouse K183-sm 9859927 RTNPAIVkTENSWSN transcription, inhibited 19625249 1 0 0 +Ppp2r1a PPP2R1A Motility/polarity/chemotaxis; PHOSPHATASE; Protein phosphatase, regulatory subunit Q76MZ3 51792 17|17 A3.2 mouse S401-p 1880515600 VIGIRQLsQSLLPAI molecular association, regulation; protein conformation; phosphorylation cell cycle regulation; DNA repair, altered; signaling pathway regulation Exportin-1(INDUCES); Akt1(DISRUPTS) 36434396 1 0 0 induces AKT phosphorylation, regulates AKT and ERK signaling +GLO1 GLO1 Carbohydrate Metabolism - pyruvate; EC 4.4.1.5; Lyase Q04760 2739 6p21.2 human T107-p 7106304 ELTHNWGtEDDETQS Glyoxalase molecular association, regulation; protein stabilization; ubiquitination; enzymatic activity, inhibited; protein conformation; enzymatic activity, induced Other(DISRUPTS) 32966793; 33459186 3 0 0 disrupts binding to Hemimercaptal; inhibits ubiquitination +Ulk1 ULK1 Autophagy; EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, Other; Protein kinase, Ser/Thr (non-receptor) NP_001101811 360827 12q16 rat S757-p 483139 PVVFTVGsPPSGTTP autophagy, inhibited 33473012; 33571535 78 15 2 +RTCB RTCB EC 6.5.1.3 Q9Y3I0 51493 22q12.3 human Y475-p 1876333510 MEEAPESyKNVTDVV RtcB molecular association, regulation RNA splicing, inhibited Other(DISRUPTS) 35193953 1 1 0 inhibits binding to GTP +TP73 p73 DNA-binding; Transcription factor; Tumor suppressor O15350 7161 1p36.32 human K331-ac 460607 AASKRAFkQSPPAVP molecular association, regulation cell growth, inhibited; apoptosis, induced; transcription, induced DNA(INDUCES) 11804596 1 0 0 induces binding to p53AIP1 gene and induces its transcription, but retains an intact ability to regulate genes. +TRIM28 TIF1B EC 6.3.2.-; KINASE; Kinase, protein; Ligase; Nuclear receptor co-regulator; Protein kinase, atypical; SUMO LIGASE; SUMO ligase; Transcription, coactivator/corepressor; UBIQUITIN LIGASE; Ubiquitin conjugating system; Ubiquitin ligase Q13263 10155 19q13.43 human Y458-p 454817 FGSGDDPySSAEPHV molecular association, regulation; phosphorylation DNA repair, induced HP1 alpha(INDUCES) DNA(NOT_REPORTED) 23645696 1 9 107 stimulates phosphorylation of TIF1B S473 and TIF1B S824 in DNA damage response; involved in DNA damage response; inhibits association of HP1alpha with chromatin +ESR1 ER-alpha DNA-binding; Nuclear receptor; Transcription factor P03372 2099 6q25.1-q25.2 human S47-p 12127400 GEVYLDSsKPAVYNY Oest_recep activity, induced transcription, altered 20043841 1 0 0 +Runx2 AML3 DNA-binding; Transcription factor Q08775 12393 17 B3|17 21.33 cM mouse S107-p 3053615 PSTSRRFsPPSSSLQ protein stabilization; molecular association, regulation transcription, induced USP24(INDUCES); SRC-3(INDUCES); p300(INDUCES) DNA(INDUCES) 37415159 8 14 1 +JUN Jun Oncoprotein; Transcription factor P05412 3725 1p32.1 human T93-p 450449 GHITTTPtPTQFLCP Jun molecular association, regulation; activity, inhibited carcinogenesis, altered; transcription, inhibited; transcription, altered; cell growth, altered MBD3(DISRUPTS); TCF4(DISRUPTS) DNA(DISRUPTS) 12853483; 21177766; 36253406; 7744008 9 3 0 +AKAP8 AKAP8 Adaptor/scaffold; Cell cycle regulation; Mitochondrial; RNA-binding O43823 10270 19p13.12 human Y311-p 3582467 KRKQFQLyEEPDTKL molecular association, regulation 25770215 1 2 31 Phenylalanine mutants inhibited dissociation from nuclear structures; structural chromatin changes +Numb NUMB Cell development/differentiation Q9QZS3 18222 12|12 D1 mouse S295-p 470030 SPFKRQLsLRINELP NumbF molecular association, regulation endocytosis, induced; cell motility, induced TrkA(INDUCES) 21571219 4 9 17 +ANXA2 ANXA2 Calcium-binding; Lipid-binding; Motility/polarity/chemotaxis Q6TEQ7 403435 dog Y24-p 449483 HSTPPSAyGSVKAYT cell motility, altered; cytoskeletal reorganization 18070928 29 64 2613 involved in the ROCK/LIMK-dependent dephosphorylation/activation of cofilin; regulates F-actin organization and dynamics +HMGN1 HMGN1 DNA-binding; Nuclear receptor co-regulator P05114 3150 21q22.2 human K48-ac 458849 AKDKSSDkKVQTKGK HMG14_17 molecular association, regulation DNA(DISRUPTS) 10753971 1 0 0 +TWIST1 TWIST1 Cell development/differentiation; DNA-binding; Inhibitor; Transcription regulation Q15672 7291 7p21.1 human S144-p 41455181 TLPSDKLsKIQTLKL HLH protein stabilization; ubiquitination 30733340 1 1 0 ; inhibits TWIST1 ubiquitination +Lrrk2 LRRK2 EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, Ser/Thr (non-receptor); Protein kinase, TKL Q5S006 66725 15|15 E3 mouse S955-p 4725908 RKRKILSsDESLRSS enzymatic activity, inhibited; phosphorylation autophagy, induced 33055242; 37454104 15 7 0 +Nrip1 RIP140 Nuclear receptor co-regulator; Transcription, coactivator/corepressor Q8CBD1 268903 16|16 C3.1 mouse R650-m1 2363401 SGPGEEQrPCKQLLS NRIP1_repr_2 transcription, induced 19216533 2 2 0 +SMAD4 SMAD4 DNA-binding; Nuclear receptor co-regulator; Transcription, coactivator/corepressor Q13485 4089 18q21.2 human Y322-p 1881244704 SNHPAPEyWCSIAYF molecular association, regulation cell cycle regulation; carcinogenesis, induced; cell growth, induced; transcription, inhibited p300(DISRUPTS); CBP(DISRUPTS); H3(DISRUPTS) 36959211 1 1 0 binding to p300 promotes p300 binding to DNA +CAMK1 CAMK1A EC 2.7.11.17; KINASE; Kinase, protein; Protein kinase, CAMK; Protein kinase, Ser/Thr (non-receptor) Q14012 8536 3p25.3 human K59-ub 28070705 AKEALEGkEGSMENE Pkinase protein degradation 23707388 1 0 0 +AKAP8 AKAP8 Adaptor/scaffold; Cell cycle regulation; Mitochondrial; RNA-binding O43823 10270 19p13.12 human Y436-p 40420003 TVEFLQEyIVNRNKK AKAP95 molecular association, regulation 25770215 1 1 0 Phenylalanine mutants inhibited dissociation from nuclear structures; structural chromatin changes +NUMA1 NuMA-1 Cell cycle regulation; Motility/polarity/chemotaxis Q14980 4926 11q13.4 human S1991-p 487347 RQQRKRVsLEPHQGP cell growth, induced; apoptosis, inhibited 23097092 2 28 42 cell proliferation increased +Eef2 EEF2 Translation; Translation elongation P58252 13629 10|10 C1 mouse T57-p 448040 RAGETRFtDTRKDEQ GTP_EFTU translation, altered 18614030 39 61 54 induces Arc/Arg 3.1 translation +CHEK2 Chk2 EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, CAMK; Protein kinase, Ser/Thr (non-receptor); Tumor suppressor O96017 11200 22q12.1 human T383-p 447545 GETSLMRtLCGTPTY Pkinase ubiquitination; intracellular localization; protein conformation; enzymatic activity, induced 11390408; 12805407; 16794575; 17698850; 20713355 9 2 6 +Smarcd3 SMARCD3 Nuclear receptor co-regulator; Transcription, coactivator/corepressor Q6P9Z1 66993 5|5 A3 mouse T229-p 8097074 HLVEWHRtPTTQETD molecular association, regulation chromatin organization, altered; cell differentiation, induced; transcription, induced SMARCA4(INDUCES) 22068056 1 0 0 +SPRY2 SPRY2 Adaptor/scaffold; Inhibitor; Motility/polarity/chemotaxis O43597 10253 13q31.1 human S121-p 465676 VSSGSRSsTRTSTSS molecular association, regulation; protein stabilization; ubiquitination BRAF(DISRUPTS); NEDD4 iso4(INDUCES) 16479008; 19690147; 19864419 3 1 0 phosphorylation of this site stabilizes protein by interfering with Y55 phosphorylation, Cbl binding and polyubiquitination ; B-Raf V600E oncogenic mutant does not associate with Spry2 (altered kinase domain conformation); interaction with NEDD4 increases the ubiquitination of Spry2 +BRIP1 BRIP1 EC 3.6.4.13; Helicase; Oncoprotein Q9BX63 83990 17q23.2 human S990-p 451461 IVISRSTsPTFNKQT molecular association, regulation cell cycle regulation BRCA1(NOT_REPORTED); BRCA1(INDUCES) 14576433; 15125843; 20173781; 22792074 6 13 0 +RUNX2 AML3 DNA-binding; Transcription factor Q13950 860 6p21.1 human S275-p 10892803 PSLNSAPsPFNPQGQ molecular association, regulation osterix(INDUCES) 25122769 5 4 0 +MAK MAK EC 2.7.11.22; KINASE; Kinase, protein; Nuclear receptor co-regulator; Protein kinase, CMGC; Protein kinase, Ser/Thr (non-receptor) P20794 4117 6p24.2 human Y159-p 462317 SQPPYTDyVSTRWYR Pkinase phosphorylation; enzymatic activity, induced cell cycle regulation 21986944 1 6 805 phosphorylates myelin basic proteins and CDH1 +MPIG6B G6B Immunoglobulin superfamily; Membrane protein, integral; Receptor, misc. O95866 80739 6p21.33 human Y211-p 10296403 DQEPSLLyADLDHLA G6B molecular association, regulation CSK(INDUCES); Src(INDUCES); Syk(INDUCES); SHP-2(INDUCES); SHP-1(INDUCES); Fyn(INDUCES); PLCG2(INDUCES); PIK3CA(INDUCES) 11544253; 23185356 3 1 4 ~70% shifting from the unbound to the bound SHP-2 fraction for the dual phosphopeptide, and ~50% and ~25% binding to the Y211 and Y237 phosphopeptides, respectively; little or no association with the individual Y211 or Y237 phosphopeptides; Only ~30% of the tandem SH2 domains of SHP-1 bound to the dual phosphopeptide +PEX5 PEX5 Membrane protein, integral; Receptor, protein translocating P50542 5830 12p13.31 human S141-p 50389701 DYNETDWsQEFISEV molecular association, regulation; ubiquitination SQSTM1(INDUCES) 26344566 1 0 0 phosphorylated at S141 becomes ubiquitylated at K209, binding to SQSTM1, and directing the autophagosome to peroxisomes to induce pexophagy +Atxn3 ataxin-3 DEUBIQUITINASE; DNA repair, damage; EC 3.4.19.12; Protease; Transcription regulation; Ubiquitin-specific protease Q9CVD2 110616 12|12 E mouse S29-p 13421402 LLQGEYFsPVELSSI Josephin intracellular localization 20347968 1 1 0 +KPNA2 KPNA2 Karyopherin; Nuclear import; Nucleoporin P52292 3838 17q24.2 human S62-p 459854 SFPDDATsPLQENRN IBB molecular association, regulation; intracellular localization cell cycle regulation; chromatin organization, altered; cytoskeletal reorganization NuMA-1(DISRUPTS); TPX2(DISRUPTS); KPNB1(DISRUPTS); KIFC1(DISRUPTS); GM130(INDUCES) 31434716; 33526712 2 69 2 +SIRT1 SIRT1 Apoptosis; DEACETYLASE; Deacetylase; EC 3.5.1.-; Nuclear receptor co-regulator Q96EB6 23411 10q21.3 human S47-p 452899 DGPGLERsPGEPGGA activity, induced; protein stabilization; intracellular localization; enzymatic activity, induced carcinogenesis, induced; DNA repair, induced; cell growth, induced; apoptosis, inhibited; transcription, induced; signaling pathway regulation p53(INDUCES) 20027304; 23754392; 34153425; 34188177 8 49 9 induces deacetylation of p53; expression and regulation of SIRT1 target antioxidative and anti-inflammatory genes increased +ICAM1 ICAM1 Cell adhesion; Immunoglobulin superfamily; Membrane protein, integral P05362 3383 19p13.2 human Y512-p 450460 RQRKIKKyRLQQAQK molecular association, regulation; protein processing cell motility, altered; cell adhesion, altered SHP-2(INDUCES) 10864922; 12902516; 14973144 5 0 1 +IRAK1 IRAK1 EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, Ser/Thr (non-receptor); Protein kinase, TKL P51617 3654 Xq28 human T381-p 394791400 QSSMVARtQTVRGTL Pkinase enzymatic activity, induced 29208712 0 1 0 +HDAC7 HDAC7 DEACETYLASE; Deacetylase; EC 3.5.1.98; Hydrolase Q8WUI4 51564 12q13.11 human S486-p 452459 RPLSRAQsSPAAPAS intracellular localization cell motility, altered; cytoskeletal reorganization; transcription, altered; cell growth, altered 15623513; 18509061; 18617643 7 31 66 important for VEGF-induced aorta ring angiogenesis; nucleo-cytoplasmic shuttling +DLGAP5 DLG7 Cell cycle regulation; Microtubule-binding Q15398 9787 14q22.3 human R122-me 1883354001 RGIFKVGrYRPDMPC intracellular localization cell motility, inhibited 36250981 1 0 0 GR (Golgi apparatus [GA]) repositioning, 122K mutant stimulated CR (centrosome repositioning), GR and cell migration +SCN5A SCN5A Channel, sodium; Membrane protein, integral; Membrane protein, multi-pass Q14524 6331 3p22.2 human S484-p 3799157 KRRKRMSsGTEECGE protein conformation 33410863 4 7 2 +Grm2 mGluR2 GPCR, family 3; Membrane protein, integral; Membrane protein, multi-pass; Receptor, GPCR P31421 24415 8q32 rat S843-p 450654 GSAAPRAsANLGQGS molecular association, regulation; activity, inhibited G-alpha 15(DISRUPTS) 10908604 1 0 0 +RIPK1 RIPK1 EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, Ser/Thr (non-receptor); Protein kinase, TKL Q13546 8737 6p25.2 human K627-ub 2188102 ERDGLKEkVYQMLQK Death protein degradation; ubiquitination; enzymatic activity, induced apoptosis, induced FADD(INDUCES); CASP8(INDUCES) 33311474; 35711363 4 4 0 Ripk1 K612R/K612R mice develop adult-onset intestinal in?ammation and splenomegaly, antibiotics rescues spontaneous gut in?ammation of RIPK1 K612R mutant mice; RDA (RIPK1 kinase dependent apoptosis) and necroptosis in response to TNFR1 signaling, p-IKKa/?, p-ERK1/2, p-JNK, and p-P38 were decreased in TNFa stimulated Ripk1K612R/K612R MEFs ; K627 localized in DD is a key ubiquitination site that can regulate the overall ubiquitination pattern of RIPK; cells stimulated by T/S and T/5Z-7; degradation and inhibited necroptosis; K627 in hRIPK1 is important for RIPK1 homodimerization +AFF1 AF-4 Oncoprotein; Transcription factor P51825 4299 4q21.3-q22.1 human K973-ac 1878271701 LHMREAKkMKQKAEL molecular association, regulation; intracellular localization transcription, inhibited MLLT3(DISRUPTS); CDK9(DISRUPTS); ELL(DISRUPTS) 31611376 1 0 0 Acetylation inhibits SEC component recruitment and is required for transcription inhibition and cell survival after exposure to genotoxic reagents. +DDX60 DDX60 EC 3.6.4.13; Hydrolase Q8IY21 55601 4q32.3 human Y793-p 2183531 PTSSGKTyASYYCME DEAD molecular association, regulation transcription, inhibited 25981042 1 1 0 reduced ATP binding, inhibited RIG-I-mediated IFN-beta promoter activation +Foxp1 FOXP1 C2H2-type zinc finger protein; Cell cycle regulation; DNA-binding; Transcription factor P58462 108655 6|6 D3 mouse S468-p 4164746 GPIRRRYsDKYNVPI intracellular localization 26171970 1 8 1 +NMT1 NMT1 EC 2.3.1.97; Motility/polarity/chemotaxis; Transferase P30419 4836 17q21.31 human Y180-p 10336300 YTLLNENyVEDDDNM NMT molecular association, regulation; enzymatic activity, induced LYN(INDUCES) 11594778 1 0 0 +SIRT3 SIRT3 DEACETYLASE; Deacetylase; EC 3.5.1.-; Mitochondrial Q9NTG7 23410 11p15.5 human S159-p 41655506 SGIPDFRsPGSGLYS SIR2 enzymatic activity, induced apoptosis, inhibited 26141949 1 0 0 +RRM2B RRM2B EC 1.17.4.1; Nucleotide Metabolism - purine; Nucleotide Metabolism - pyrimidine; Other Amino Acids Metabolism - glutathione; Oxidoreductase Q7LG56 50484 8q22.3 human S72-p 5014902 TAEEVDLsKDLPHWN Ribonuc_red_sm protein stabilization; ubiquitination cell cycle regulation 19015526 1 0 0 S72A-RRM2B mutant is hyperubiquitinated in UV-irradiated cells +Akap12 AKAP12 Adaptor/scaffold Q5QD51 83425 1q11 rat S507-p 469987 SPLKKLFsSSGLKKL molecular association, regulation cell cycle regulation CCNE1(DISRUPTS); CCND1(DISRUPTS) 10982843; 11820772 2 12 1 shown with PKC phosphorylated and nonphosphorylated AKAP12; in vivo permeable peptide/phosphopeptide experiments +GLI1 GLI1 C2H2-type zinc finger protein; Oncoprotein; Transcription factor P08151 2735 12q13.3 human R597-m2 59171800 RARYASArGGGTSPT molecular association, regulation carcinogenesis, induced; cell motility, induced; cell growth, induced; apoptosis, inhibited; transcription, induced DNA(INDUCES) 27758883 1 1 0 +Tmbim1 TMBIM1 Membrane protein, integral; Membrane protein, multi-pass Q8BJZ3 69660 1|1 C3 mouse K211-ub 1873041106 TIFCFQTkVDFTSCT Bax1-I molecular association, regulation Hrs(INDUCES) 28481357 1 1 0 +Polr2a POLR2A EC 2.7.7.48; EC 2.7.7.6; Nucleotide Metabolism - purine; Nucleotide Metabolism - pyrimidine; Transcription initiation complex; Transferase P08775 20020 11 B3|11 42.86 cM mouse K1859-ub 2134723 EYTPASPkYSPTSPK RNA_pol_Rpb1_R protein degradation 17526739 1 1 0 +Lef1 LEF-1 DNA-binding; Transcription factor P27782 16842 3 G3|3 60.78 cM mouse K267-sm 2535909 AIVTPQVkQEHPHTD intracellular localization; activity, inhibited transcription, inhibited 11731474 1 0 0 +TAGLN TAGLN Actin-binding; Motility/polarity/chemotaxis; Nuclear receptor co-regulator Q01995 6876 11q23.3 human K89-ub 1881229500 NPPSMVFkQMEQVAQ protein degradation; ubiquitination 33771884 1 0 0 +Mitf MITF iso8 DNA-binding; Oncoprotein; Transcription factor Q08874-8 17342 6 D3|6 45.05 cM mouse S73-p 450264 PGSSAPNsPMAMLTL MITF_TFEB_C_3_N molecular association, regulation transcription, inhibited PIAS3(INDUCES) 14645519 16 1 0 +FBXW7 FBXW7 Motility/polarity/chemotaxis; Nucleolus; UBIQUITIN LIGASE; Ubiquitin conjugating system; Ubiquitin ligase Q969H0 55294 4q31.3 human S26-p 482101 LRGNPSSsQVDEEQM intracellular localization 26774286 1 1 0 recruitment to DNA damage sites +GTF2I GTF2I iso2 DNA-binding; Transcription, coactivator/corepressor P78347-2 2969 7q11.23 human Y248-p 448250 EESEDPDyYQYNIQG molecular association, regulation cell cycle regulation; transcription, induced; transcription, altered ERK1(INDUCES) 11313464; 11373296; 11934902; 16314517 8 2 9 +Ppara PPAR-alpha DNA-binding; Nuclear receptor; UBIQUITIN LIGASE P37230 25747 7q34 rat T129-p 457548 CKGFFRRtIRLKLAY zf-C4 activity, induced; molecular association, regulation; intracellular localization transcription, induced; transcription, altered RXRA(INDUCES) DNA(INDUCES) 16042408; 22091731 2 0 0 +BACE1 BACE EC 3.4.23.46; Membrane protein, integral; Protease P56817 23621 11q23.3 human T252-p 48881800 YTGSLWYtPIRREWY Asp activity, induced 26317805 1 0 0 +BCKDK BCKDK EC 2.7.11.4; KINASE; Kinase, protein; Mitochondrial; Protein kinase, Ser/Thr (non-receptor); Protein kinase, atypical O14874 10295 16p11.2 human Y246-p 1868515109 RRLCEHKyGNAPRVR protein stabilization; ubiquitination; phosphorylation; enzymatic activity, induced carcinogenesis, induced; cell motility, induced 32238881 1 0 0 induces phosphorylation of MEK and BCKDHA, inhibits ubiquitination +H3-3A H3 DNA-binding Q5E9F8 326601 cow K36-m2 1458610 APSTGGVkKPHRYRP Histone cell cycle regulation; cell growth, inhibited; transcription, inhibited 16805913 44 18 7 +BECN1 beclin 1 Adaptor/scaffold; Autophagy; Membrane protein, peripheral Q14457 8678 17q21.31 human Y333-p 1874101912 QRYRLVPyGNHSYLE APG6 activity, induced; molecular association, regulation carcinogenesis, induced; autophagy, induced; cell growth, induced; apoptosis, inhibited rubicon(DISRUPTS); Bcl-2(DISRUPTS); PIK3R4(INDUCES); PIK3C3(INDUCES) 34131122 1 0 0 +Ptpn11 SHP-2 EC 3.1.3.48; Motility/polarity/chemotaxis; PHOSPHATASE; Protein phosphatase, tyrosine (non-receptor) P41499 25622 12q16 rat Y580-p 448493 REDSARVyENVGLMQ molecular association, regulation; phosphorylation caveolin-1(INDUCES) 25672415 18 60 1189 deletion SHP-2 SH2 domain reduces Src Y419 phosphorylation +Klf9 KLF9 C2H2-type zinc finger protein; DNA-binding Q01713 rat S110-p 241497503 SGSSPSHsPEERQDS molecular association, regulation cell motility, inhibited JNK3(INDUCES) 28871032 1 1 0 suppress neurite growth, KLF9 S106/110A mutants enhance optic nerve axon regeneration 2 weeks after optic nerve injury +E2F1 E2F1 DNA-binding; Transcription factor Q01094 1869 20q11.22 human T130-p 1870773101 GEKSRYEtSLNLTTK E2F_TDP protein degradation; enzymatic activity, induced cell cycle regulation; cell growth, inhibited; apoptosis, induced 33110360 1 0 0 induces ?-galactosidase activity +ZAP70 ZAP70 EC 2.7.10.2; KINASE; Kinase, protein; Protein kinase, TK; Protein kinase, tyrosine (non-receptor) P43403 7535 2q11.2 human K544-ub 55588401 QKPYKKMkGPEVMAF PK_Tyr_Ser-Thr molecular association, regulation; enzymatic activity, inhibited; phosphorylation cell differentiation, inhibited; transcription, inhibited; signaling pathway regulation STS-1(INDUCES); STS2(INDUCES) 26903241 1 2 0 regulates TCR signaling, inhibits phosphorylation of itself and downstream targets +IL22RA1 IL22RA1 Membrane protein, integral Q8N6P7 58985 1p36.11 human Y251-p 15512803 AVLCYLSyRYVTKPP molecular association, regulation SHP-2(INDUCES) 20671117 1 0 0 necessary for IL22RA1 to mediate the IL-22-stimulated MAP kinases and STAT3 activation +SLC9A1 NHE1 Membrane protein, integral; Membrane protein, multi-pass; Motility/polarity/chemotaxis; Transporter; Transporter, SLC family P19634 6548 1p36.11 human T653-p 4729330 LRSYNRHtLVADPYE NEXCaM_BD activity, induced cell motility, induced; cytoskeletal reorganization; cell growth, altered 25578862; 27555478 2 2 2 stress fiber formation, in S703A and T653A mutants proliferation was substantially higher +PRKCA PKCA EC 2.7.11.13; KINASE; Kinase, protein; Oncoprotein; Protein kinase, AGC; Protein kinase, Ser/Thr (non-receptor) P17252 5578 17q24.2 human S226-p 2050181 LNPQWNEsFTFKLKP C2 molecular association, regulation; enzymatic activity, induced RhoGDI beta(INDUCES) 26414765 1 44 42 +IDH1 IDH1 Carbohydrate Metabolism - citrate (TCA) cycle; EC 1.1.1.42; Other Amino Acids Metabolism - glutathione; Oxidoreductase O75874 3417 2q34 human Y42-p 3563660 VELDLHSyDLGIENR Iso_dh molecular association, regulation IDH1(INDUCES) 30862724 1 2 2 +KANSL3 KANSL3 iso3 Unknown function Q9P2N6-3 55683 2q11.2 human T755-gl 1879982200 PGPAPQAtSVKLPTP protein stabilization 31881804 1 1 0 H4 K5, K8, and K16 levels increased by T755-gl stabilization +TBC1D4 AS160 GAP; GAP, Rab O60343 9882 13q22.2 human S318-p 455925 EFRSRCSsVTGVQRR PID molecular association, regulation endocytosis, induced; signaling pathway regulation 14-3-3 epsilon(INDUCES) 20410134; 26465605 13 18 334 albumin endocytosis; multiple sites (6P) mutant +Tfe3 TFE3 DNA-binding; Oncoprotein; Transcription factor Q64092 209446 X A1.1|X 3.5 cM mouse S320-p 53350801 PAITVSNsCPAELPN intracellular localization; activity, inhibited transcription, inhibited 27913603; 35358174 5 1 0 +GLI1 GLI1 C2H2-type zinc finger protein; Oncoprotein; Transcription factor P08151 2735 12q13.3 human S1089-p 1873647706 NMAVGNMsVLLRSLP protein stabilization; molecular association, regulation; intracellular localization carcinogenesis, induced; cell growth, induced; transcription, induced SUFU(DISRUPTS) 34052323 1 1 0 +GAB1 GAB1 Adaptor/scaffold; Motility/polarity/chemotaxis Q13480 2549 4q31.21 human Y242-p 455030 FFQQQMIyDSPPSRA molecular association, regulation CDK6(INDUCES) 19881549 2 8 269 promotes HGF-induced DNA synthesis +PDE4D PDE4D iso6 EC 3.1.4.53; Nucleotide Metabolism - purine; Phosphodiesterase Q08499-6 5144 5q11.2-q12.1 human K53-ub 7388019 ARKSVSPkLSPVISP molecular association, regulation RACK1(DISRUPTS); ARRB1(INDUCES) 19372219 1 0 0 +GABARAPL2 GABARAPL2 Adaptor/scaffold; Autophagy; Microtubule-binding; Ubiquitin-like modifier; Vesicle P60520 11345 16q23.1 human S88-p 1869546302 DKTVPQSsLTMGQLY ATG8 molecular association, regulation apoptosis, induced ATG4B(DISRUPTS) 31709703 1 1 0 ; including ATG4A, ATG4C, ATG4D +DLGAP1 SAPAP1 iso2 Cytoskeletal O14490-2 9229 18p11.31 human S393-p 4775408 RRFTRSNsVTTAVQA GKAP molecular association, regulation; intracellular localization neural plasticity DLC1(DISRUPTS) 23143515 1 0 0 +HNRNPK hnRNP K RNA splicing; RNA-binding; Spliceosome P61978 3190 9q21.32 human Y234-p 456002 PNFYDETyDYGGFTM translation, altered 12052863 1 1 0 based on Y72/225/230/234/236/380A mutant +Etv4 ETV4 DNA-binding P28322 18612 11 D|11 65.48 cM mouse K261-ac 26373301 PGAGVVIkQERTDFA ETS_PEA3_N sumoylation transcription, induced 21543453 1 1 0 acetylated sites inhibits sumoylation reciprocally +BRCA1 BRCA1 EC 6.3.2.-; Nuclear receptor co-regulator; Transcription, coactivator/corepressor; Tumor suppressor; UBIQUITIN LIGASE; Ubiquitin conjugating system; Ubiquitin ligase P38398 672 17q21.31 human Y1552-p 50684000 HDLTETSyLPRQDLE protein stabilization 29156836 1 1 0 +CFTR CFTR Channel, chloride; EC 3.6.3.49; Hydrolase; Membrane protein, integral; Membrane protein, multi-pass; Transporter; Transporter, ABC family P13569 1080 7q31.2 human T582-p 2907507 FGYLDVLtEKEIFES activity, induced 12588899; 14695900 2 0 0 +PPP1R12A MYPT1 Motility/polarity/chemotaxis; PHOSPHATASE; Protein phosphatase, regulatory subunit O14974 4659 12q21.2-q21.31 human S507-p 477839 TIPRRLAsTSDIEEK cytoskeletal reorganization 37064875 2 51 789 +FHOD1 FHOD1 Actin-binding Q9Y613 29109 16q22.1 human S1137-p 2035403 RSRGNRKsLRRTLKS activity, induced cytoskeletal reorganization; cell growth, altered FHOD1(DISRUPTS) 18239683; 21106951 2 1 10 autoinhibitory interaction between C- and N-terminal part of FHOD1 is attenuated in S1130D/S1136D/T1140D triple mutant +Ltb4r LTB4R GPCR, family 1; Membrane protein, integral; Membrane protein, multi-pass; Receptor, GPCR O88855 16995 14 C3|14 28.19 cM mouse S127-p 2862101 AVARPFMsQKVRTKA 7tm_1 receptor desensitization, altered 17595524 1 0 0 +Marcks MARCKS Actin-binding; Motility/polarity/chemotaxis P26645 17118 10 B1|10 19.49 cM mouse S160-p 466360 FKKSFKLsGFSFKKS MARCKS intracellular localization carcinogenesis, induced; cell motility, altered 20211725 7 44 11 +Alyref2 Refbp2 DNA-binding; RNA-binding Q9JJW6 56009 1|1 H3 mouse R181-m2 13906406 GSGGFGGrGSQGRGR FoP_duplication molecular association, regulation RNA(DISRUPTS) 20129943 1 1 0 +PCK1 PCK1 Carbohydrate Metabolism - citrate (TCA) cycle; Carbohydrate Metabolism - glycolysis and gluconeogenesis; Carbohydrate Metabolism - pyruvate; EC 4.1.1.32; KINASE; Kinase, other; Lyase; Protein kinase, Ser/Thr (non-receptor) P35558 5105 20q13.31 human S90-p 1868515110 RDVARIEsKTVIVTQ PEPCK_N protein degradation; acetylation; ubiquitination; intracellular localization; protein conformation; activity, inhibited carcinogenesis, induced 30193097; 32322062; 33842305 3 1 0 +CSF3R GCSFR Membrane protein, integral; Receptor, cytokine Q99062 1441 1p34.3 human K695-ub 9381805 LGTPPITkLTVLEED receptor internalization, induced; protein degradation; intracellular localization; phosphorylation cell growth, inhibited; signaling pathway regulation 19453968 1 0 0 regulates production of neutrophilic granulocytes, regulates STAT5 activation +CSNK1E CK1E EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, CK1; Protein kinase, Ser/Thr (non-receptor) P49674 1454 22q13.1 human S323-p 453416 RMGQLRGsATRALPP enzymatic activity, inhibited 10542239; 12223474 2 4 1 some subset of these 8 sites +Anxa2 ANXA2 Calcium-binding; Lipid-binding; Motility/polarity/chemotaxis Q07936 56611 8q24 rat S26-p 450879 TPPSAYGsVKPYTNF translation, inhibited 34346292 14 29 100 +RECQL4 RECQL4 EC 3.6.4.12; Helicase O94761 9401 8q24.3 human K376-ac 7106307 LRSRLLRkQAWKQKW intracellular localization 19299466 1 0 0 accumulates in the cytoplasm +PDE4B PDE4B EC 3.1.4.53; Nucleotide Metabolism - purine; Phosphodiesterase Q07343 5142 1p31.3 human S659-p 471380 YQSMIPQsPSPPLDE enzymatic activity, inhibited 11030732 1 5 0 increases levels of cAMP +Gja1 GJA1 Channel, misc.; Membrane protein, integral; Membrane protein, multi-pass; Motility/polarity/chemotaxis P08050 24392 20q11 rat S325-p 449992 NRMGQAGsTISNSHA Connexin43 intracellular localization cell adhesion, induced; cell adhesion, altered; signaling pathway regulation 12270943; 23742896 10 14 0 cardiomyocyte FGF signaling, maintenance of cell-cell gap junctions +DLGAP1 SAPAP1 iso2 Cytoskeletal O14490-2 9229 18p11.31 human S349-p 2049913 FKKNRCLsIGIQVDD GKAP molecular association, regulation; intracellular localization neural plasticity DLC1(DISRUPTS) 23143515 1 3 0 +ING3 ING3 Transcription, coactivator/corepressor Q9NXR8 54556 7q31.31 human K96-ub 11489912 LVDRHLRkLDQELAK ING protein degradation; molecular association, regulation cell cycle regulation; carcinogenesis, induced; apoptosis, inhibited SKP2(INDUCES) 19935701 1 0 0 +CD6 CD6 Cell surface; Membrane protein, integral P30203 923 11q12.2 human Y662-p 450239 DSTDNDDyDDISAA_ activity, induced; molecular association, regulation SLP76(INDUCES); GADS(INDUCES) 28289074 2 1 0 +GMFG GMF-gamma Actin-binding O60234 9535 19q13.2 human S2-p 467229 ______MsDSLVVCE molecular association, regulation cytoskeletal reorganization ARPC3(INDUCES); ACTA1(INDUCES) 16873721 1 1 0 phosphorylation of this site enhances binding of GMFG to F-actin and reduces the interaction between F-actin and cofilin +Dlg4 PSD-95 Adaptor/scaffold P31016 29495 10q24 rat Y397-p 473889 AQYKPEEySRFEAKI protein conformation CRIPT(DISRUPTS) 21965656 3 1 6 Y397E mutant showed dissociation, triple mutant Y397E/S415E/S418E showed stronger dissociation +SLBP SLBP RNA-binding Q14493 7884 4p16.3 human T62-p 466352 RRPESFTtPEGPKPR protein degradation; molecular association, regulation; phosphorylation apoptosis, inhibited CUL4A(INDUCES); WDR23(INDUCES) 12588979; 18490441; 27254819 4 6 8 degradation is essential for the viability of cells +HTR6 5-HT(6) GPCR, family 1; Membrane protein, integral; Membrane protein, multi-pass; Receptor, GPCR P50406 3362 1p36.13 human S350-p 1867750504 ERQASLAsPSLRTSH molecular association, regulation; activity, inhibited; enzymatic activity, induced cell growth, induced GRIN1(DISRUPTS) 32047117 1 0 0 induces Cdc42 activity further enhancing neurite growth +H4c2 H4 DNA-binding P62806 326620 13|13 A3.1 mouse K12-ac 459013 KGGKGLGkGGAKRHR cell cycle regulation; chromatin organization, altered; apoptosis, induced; transcription, induced; transcription, altered; transcription, inhibited 17344422; 17530637; 17626110; 17823087; 19641176; 19965984; 20448184; 20710121 93 25 531 may be associated with gene expression +Slc12a3 NCCT Membrane protein, integral; Membrane protein, multi-pass; Transporter; Transporter, SLC family P59158 20497 8 C5|8 46.46 cM mouse T58-p 469617 MRTFGYNtIDVVPAY AA_permease_N activity, induced; protein stabilization; ubiquitination; intracellular localization; phosphorylation 20962898; 22846565; 23833262; 34174287 25 3 0 +ERBB2 HER2 EC 2.7.10.1; KINASE; Kinase, protein; Membrane protein, integral; Oncoprotein; Protein kinase, TK; Protein kinase, tyrosine (receptor) P04626 2064 17q12 human Y1222-p 448675 PAFDNLYyWDQDPPE molecular association, regulation; enzymatic activity, induced carcinogenesis, induced; apoptosis, inhibited; cell motility, altered; transcription, induced; signaling pathway regulation; cell growth, altered GRB2(INDUCES); MEMO1(INDUCES); SHC1(INDUCES) 11238891; 15156151; 16729043; 18332126; 19525980; 20498373; 21840311; 37324940 36 1 8 +Bub1b BUB1B EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, Other; Protein kinase, Ser/Thr (non-receptor); Tumor suppressor Q9Z1S0 12236 2|2 E5 mouse S665-p 767909 LSPIIEEsREATHSS phosphorylation 26028219 9 4 0 decrease CASC5 phosphorylation +IRF1 IRF1 Transcription factor; Tumor suppressor P10914 3659 5q31.1 human Y109-p 2299205 GSSAVRVyRMLPPLT IRF transcription, altered 11483597 1 0 0 +BIK BIK Apoptosis; Membrane protein, integral; Mitochondrial Q13323 638 22q13.2 human K115-ub 21129908 MDGFTTLkENIMRFW bcl-2I13 protein degradation; ubiquitination apoptosis, inhibited 31387940 1 3 0 IRE1alpha?XBP1 axis prevents premature apoptosis allows time for cell adaptation to ER stress +MAZ MAZ C2H2-type zinc finger protein; RNA-binding; Transcription factor O97600 100008693 rabbit T386-p 449095 KDRLRAHtVRHEEKV activity, induced; protein conformation transcription, induced DNA(INDUCES) 12697757 2 0 0 +GFPT1 GFAT iso2 Amino Acid Metabolism - alanine, aspartate and glutamate; Carbohydrate Metabolism - amino sugar and nucleotide sugar; EC 2.6.1.16; Transferase Q06210-2 2673 2p13.3 human S243-p 467935 CNLSRVDsTTCLFPV O-GlcNAc glycosylation; enzymatic activity, inhibited cell differentiation, induced 19170765; 28008135 4 83 522 promotes angiogenesis +YAP1 YAP1 Oncoprotein; Transcription, coactivator/corepressor P46937 10413 11q22.1 human S217-p 33668511 MNVTAPTsPPVQQNM molecular association, regulation apoptosis, inhibited TEAD4(DISRUPTS) 24812269 1 0 0 +Eif4b EIF4B RNA-binding; Translation; Translation initiation Q8BGD9 75705 15|15 F2 mouse S406-p 470374 RPRERHPsWRSEETQ translation, altered 18836482 8 50 670 +Top1 TOP1 EC 5.99.1.2; Isomerase; Nucleolus; Oncoprotein Q04750 21969 2 H2|2 80.96 cM mouse Y270-p 454026 AKMLDHEyTTKEIFR Topoisom_I_N enzymatic activity, induced 15448168 1 2 1 phosphorylation of this site stimulates the TOP1 isomerase function +Src Src EC 2.7.10.2; KINASE; Kinase, protein; Oncoprotein; Protein kinase, TK; Protein kinase, tyrosine (non-receptor) P05480 20779 2 H1|2 78.35 cM mouse S74-p 450326 NSSDTVTsPQRAGPL cell differentiation, induced; transcription, induced 33798451 9 24 3 +POLL POLL DNA repair, damage; EC 2.7.7.7; Lyase; Transferase Q9UGP5 27343 10q24.32 human T204-p 62925702 EASDGEEtQVSAADL molecular association, regulation DNA repair, induced Ku80(INDUCES) 28109743 1 0 0 +RELA NFkB-p65 DNA-binding; Nuclear receptor co-regulator; Transcription factor Q04206 5970 11q13.1 human T305-p 10800660 IEEKRKRtYETFKSI transcription, inhibited 28416608 1 1 1 impaired acetylation of p65 at K310 +LIPE HSL EC 3.1.1.79; Lipase Q05469 3991 19q13.2 human S951-p 450195 GFHPRRSsQGATQMP Abhydrolase_3 molecular association, regulation; enzymatic activity, induced FABP4(INDUCES) 17785468; 19018281 29 14 16 +DRD1 DRD1 GPCR, family 1; Membrane protein, integral; Membrane protein, multi-pass; Receptor, GPCR P21728 1812 5q35.2 human T439-p 1869357201 LEKIQPItQNGQHPT molecular association, regulation signaling pathway regulation G-alpha(s)(INDUCES); ARR3(INDUCES) 32503917 1 0 0 ERK1/2 activation +VAV2 VAV2 GEF; GEF, Rac/Rho; Motility/polarity/chemotaxis P52735 7410 9q34.2 human Y172-p 452202 EDGGDDIyEDIIKVE activity, induced; molecular association, regulation cell growth, induced; cell adhesion, induced MST3(INDUCES) 25386896; 26910843 3 0 3 increased VAV2 Y172 phosphorylation +FGFR3 FGFR3 EC 2.7.10.1; KINASE; Kinase, protein; Membrane protein, integral; Protein kinase, TK; Protein kinase, tyrosine (receptor) P22607 2261 4p16.3 human Y724-p 448116 ANCTHDLyMIMRECW PK_Tyr_Ser-Thr molecular association, regulation; phosphorylation; enzymatic activity, induced transcription, altered; cell growth, altered SH2-B-beta(INDUCES) 11294897; 11827956 2 1 2 stimulates phosphorylation of Shp2, MAPK, Stat1 and Stat3, activates PI3K; stimulates the transforming activity of FGFR3 +XPA XPA DNA repair, damage P23025 7507 9q22.33 human S196-p 460698 RSLEVWGsQEALEEA protein stabilization; molecular association, regulation DNA repair, induced; apoptosis, altered H2AX(INDUCES); HERC2(DISRUPTS); RPA1(INDUCES) DNA(INDUCES) 16540648; 23178497; 35216341 6 3 0 +Nefl NFL Cytoskeletal P08551 18039 14|14 D1 mouse S56-p 451024 SSLSVRRsYSSSSGS Filament_head molecular association, regulation; intracellular localization 14-3-3 gamma(INDUCES) 23230147 9 3 1 regulates NF-L dynamic exchange rate and neurofilament disassembly +H4C1 H4 DNA-binding P62805 8359 6p22.2 human K20-m2 465128 GGAKRHRkVLRDNIQ CENP-T_C acetylation; molecular association, regulation; intracellular localization cell cycle regulation; DNA repair, induced; transcription, inhibited FANCD2(INDUCES); 53BP1(DISRUPTS); MBTD1(INDUCES); JMJD2A(INDUCES); CRB2(INDUCES); 53BP1(INDUCES) 17190600; 17967882; 18470998; 19706462; 23329852; 27153538; 31085681; 31911551; 33188174 30 16 1 HBD/MBD is required for ef?cient chromatin binding and nuclear focus formation; MBTD1 can displace 53BP1 from the H4K20me2 histone mark +CRK CRK Adaptor/scaffold; Motility/polarity/chemotaxis; Oncoprotein P46108 1398 17p13.3 human S41-p 454189 VFLVRDSsTSPGDYV SH2 carcinogenesis, induced; cell motility, induced; transcription, inhibited 22848689 2 18 17 +Dag1 DAG1 Cytoskeletal; Membrane protein, integral; Motility/polarity/chemotaxis Q62165 13138 9 F1|9 59.08 cM mouse Y890-p 449630 PYRSPPPyVPP____ DAG1 receptor internalization, induced; protein degradation; molecular association, regulation; intracellular localization cytoskeletal reorganization Tks5(INDUCES) 12795607; 18982058; 22810924; 28591567; 28852008 8 2 19 +KCNJ10 Kir4.1 Channel, ligand-gated; Channel, potassium; Membrane protein, integral; Membrane protein, multi-pass P78508 3766 1q23.2 human Y9-p 3477640 TSVAKVYySQTTQTE activity, induced 23873931 1 1 4 induce whole cell K current, and may regulate channel number in plasma membrane +SFN 14-3-3 sigma Adaptor/scaffold P31947 2810 1p36.11 human S186-p 456054 FHYEIANsPEEAISL 14-3-3 molecular association, regulation; phosphorylation apoptosis, induced CBY1(DISRUPTS); JNK1(INDUCES); BAX(DISRUPTS) 15071501; 16009721; 26147002 5 0 0 +PTEN PTEN Carbohydrate Metabolism - inositol phosphate; EC 3.1.3.16; EC 3.1.3.48; EC 3.1.3.67; Motility/polarity/chemotaxis; Nuclear receptor co-regulator; PHOSPHATASE; Phosphatase, lipid; Tumor suppressor P60484 5728 10q23.31 human S229-p 456213 VKIYSSNsGPTRRED PTEN_C2 cell motility, altered 15793569 1 1 1 +ESR2 ER-beta DNA-binding; Nuclear receptor Q92731 2100 14q23.2-q23.3 human S200-p 23068601 IDKNRRKsCQACRLR zf-C4 molecular association, regulation DNA(DISRUPTS) 34147032 2 1 0 +Nr3c1 GR DNA-binding; Mitochondrial; Nuclear receptor; Transcription factor P06537 14815 18 B3|18 21.09 cM mouse K310-sm 2532300 LCTPGVIkQEKLGPV GCR transcription, inhibited 26712002 7 3 0 +TGFBR2 TGFBR2 EC 2.7.11.30; KINASE; Kinase, protein; Membrane protein, integral; Oncoprotein; Protein kinase, Ser/Thr (receptor); Protein kinase, TKL P37173 7048 3p24.1 human K567-ne 27581513 DGSLNTTk_______ protein stabilization; ubiquitination 23290524 1 0 0 antagonizes its ubiquitination +Myh9 MYH9 Actin-binding; Motility/polarity/chemotaxis; Motor Q8VDD5 17886 15 E1|15 36.81 cM mouse S1943-p 456730 RKGTGDCsDEEVDGK cell motility, induced; cytoskeletal reorganization; cell motility, inhibited 22025714; 32315395 14 118 916 +PTH1R PTHR GPCR, family 2; Membrane protein, integral; Membrane protein, multi-pass; Receptor, GPCR Q03431 5745 3p21.31 human Y494-p 28764913 ARSGSSSySYGPMVS intracellular localization cell differentiation, induced; cytoskeletal reorganization 29507819 1 2 0 length of dendrites was decreased in Y494F cells; Y-PTH1R localizes to dendrites during osteoblast-to-osteocyte differentiation in vivo; Y494-phosphorylation site speci?cally contributed to polymerization of actin ?laments +IGFBP1 IGFBP1 Secreted; Secreted, signal peptide P08833 3484 7p12.3 human S199-p 51637400 ETSGEEIsKFYLPNC Thyroglobulin_1 molecular association, regulation; activity, inhibited signaling pathway regulation CK2B(INDUCES) 32502935 4 4 0 regulates mTOR and AAR signaling +RAD54L RAD54L Cell cycle regulation; DNA repair, damage; EC 3.6.1.-; EC 3.6.4.-; Helicase Q92698 8438 1p34.1 human S49-p 31855101 QIQECFLsPFRKPLS protein conformation DNA repair, inhibited DNA(DISRUPTS) 29295984 1 3 0 impairs DNA-dependent RAD54 oligomerization and inhibits RAD54 branch migration (BM) activity +ETV6 Tel DNA-binding; Motility/polarity/chemotaxis; Oncoprotein; Transcription factor P41212 2120 12p13.2 human S257-p 451378 ESHPKPSsPRQESTR molecular association, regulation; intracellular localization; activity, inhibited cell differentiation, altered; transcription, induced; transcription, inhibited; cell growth, altered DNA(DISRUPTS) 15060146; 18022807 3 2 0 +Nos1 nNOS Amino Acid Metabolism - arginine and proline; EC 1.14.13.39; Oxidoreductase P29476 24598 12q16 rat K38-ac 2459105 LVKERVSkPPVIISD PDZ activity, induced 18415985 1 1 0 +NBN NBS1 Cell cycle regulation; DNA repair, damage O60934 4683 8q21.3 human K334-ac 487509 GHPSTGLkTTTPGPS phosphorylation cell cycle regulation; apoptosis, induced 17612497 2 1 0 inhibits phosphorylation at S343 +PIAS1 PIAS1 EC 6.3.2.-; Nuclear receptor co-regulator; SUMO LIGASE; SUMO conjugating system; SUMO ligase; Transcription, coactivator/corepressor O75925 8554 15q23 human S467-p 4700788 IDLTIDSsSDEEEEE molecular association, regulation transcription, inhibited SUMO2(INDUCES); SUMO1(INDUCES); UBC9(INDUCES) 19217413; 24174529 2 8 0 +XRCC5 Ku80 DNA-binding; EC 3.6.1.-; EC 3.6.4.-; Helicase; Nuclear receptor co-regulator; Nucleolus; RNA-binding P13010 7520 2q35 human K465-ub 12344137 IDSMSLAkKDEKTDT molecular association, regulation DNA repair, induced DNA(DISRUPTS) 27895153 1 1 2 +RPL11 RPL11 Motility/polarity/chemotaxis; Nucleolus; Ribosomal; Translation P62913 6135 1p36.11 human K178-ne 12067613 DGIILPGk_______ protein stabilization; intracellular localization 19713960 1 0 0 +Cadps CADPS Vesicle Q62717 26989 15p15 rat S6-p 7712500 __MLDPSsSEEESDE activity, induced exocytosis, altered 19460754 1 2 0 +SP1 SP1 C2H2-type zinc finger protein; DNA-binding; Transcription factor P08047 6667 12q13.13 human S101-p 767911 DLTATQLsQGANGWQ sumoylation; protein degradation; molecular association, regulation; protein stabilization; ubiquitination; intracellular localization DNA repair, induced; DNA repair, altered RNF4(INDUCES) 18619531; 22826432; 25355892; 35124373 6 0 0 induces sumoylation +BTRC BTRC Motility/polarity/chemotaxis; UBIQUITIN LIGASE; Ubiquitin conjugating system; Ubiquitin ligase Q9Y297 8945 10q24.32 human S82-p 1869876000 SLRQTYNsCARLCLN protein degradation; ubiquitination signaling pathway regulation 31406304 1 0 0 +IRF7 IRF7 DNA-binding; Transcription factor Q92985 3665 11p15.5 human K375-ub 573779820 ARRMGKCkVYWEVGG IRF-3 transcription, induced 35792897 1 2 0 increased levels of H3K27ac on IRF7 binding regions +Plekho1 PLEKHO1 Adaptor/scaffold; Tumor suppressor Q9JIY0 67220 3|3 F2.1 mouse S341-p 12739074 KAKDPPQsPPDSESE protein degradation; ubiquitination 24777252 1 4 0 +Grm7 mGluR7 GPCR, family 3; Membrane protein, integral; Membrane protein, multi-pass; Receptor, GPCR P35400 81672 4q41 rat S862-p 2846504 NVQKRKRsFKAVVTA molecular association, regulation; receptor internalization, inhibited endocytosis, inhibited Calmodulin(DISRUPTS) 12021391; 23612982 4 0 0 +Gja1 GJA1 Channel, misc.; Membrane protein, integral; Membrane protein, multi-pass; Motility/polarity/chemotaxis P23242 14609 10 B4|10 28.64 cM mouse S365-p 459207 IVDQRPSsRASSRAS intracellular localization; protein conformation 17714073; 29269353 15 15 2 +Ngef ephexin-1 GEF; GEF, Rac/Rho Q8CHT1 53972 1 D|1 44.42 cM mouse Y177-p 455579 IEQIGLLyQEYRDKS activity, induced cell motility, altered; cytoskeletal reorganization 15848799 4 0 2 +Tgfbr2 TGFBR2 iso1 EC 2.7.11.30; KINASE; Kinase, protein; Membrane protein, integral; Oncoprotein; Protein kinase, Ser/Thr (receptor); Protein kinase, TKL Q62312-1 21813 9 F3|9 68.39 cM mouse Y309-p 479864 KIFPYEEySSWKTEK PK_Tyr_Ser-Thr cytoskeletal reorganization; cell growth, altered 18174260 3 0 0 important for TGF beta -induced cell invasion +MET Met EC 2.7.10.1; KINASE; Kinase, protein; Membrane protein, integral; Oncoprotein; Protein kinase, TK; Protein kinase, tyrosine (receptor) P08581 4233 7q31.2 human Y1349-p 448472 STFIGEHyVHVNATY activity, induced; molecular association, regulation; enzymatic activity, induced carcinogenesis, induced; cell motility, induced; cell growth, induced; cell motility, altered; signaling pathway regulation; cell growth, altered GRB2(INDUCES); Src(INDUCES); PLCG1(INDUCES); Ron(INDUCES); GAB1(INDUCES); Met(INDUCES); SHC1(INDUCES); FAK(INDUCES); PIK3R1(INDUCES) 10490849; 10506185; 10871856; 12766170; 16782899; 21777671; 24634221; 27401557; 7513258; 7687741; 7731718; 8906793; 9391119; 9826708 30 6 125 +Pxn PXN Adaptor/scaffold; Cell adhesion; Cytoskeletal; Motility/polarity/chemotaxis Q8VI36 19303 5 F|5 56.1 cM mouse Y40-p 449965 YPTGNHTyQEIAVPP apoptosis, inhibited 30604146 3 3 28 +MYB Myb DNA-binding; Oncoprotein; Transcription factor P10242 4602 6q23.3 human S12-p 448187 PRHSIYSsDEDDEDF molecular association, regulation transcription, altered DNA(DISRUPTS) 7735324 5 1 2 +NCOA1 SRC-1 ACETYLTRANSFERASE; Acetyltransferase; DNA-binding; EC 2.3.1.48; Nuclear receptor co-regulator; Oncoprotein; Transcription, coactivator/corepressor Q15788 8648 2p23.3 human T1179-p 449063 NYGTNPGtPPASTSP DUF1518 transcription, altered 11073973; 12163482 4 0 0 +Tbk1 TBK1 EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, Other; Protein kinase, Ser/Thr (non-receptor) Q9WUN2 56480 10|10 D2 mouse S172-p 447732 EDDEQFVsLYGTEEY Pkinase intracellular localization; phosphorylation; enzymatic activity, induced carcinogenesis, induced; carcinogenesis, inhibited; cell growth, inhibited; transcription, induced; transcription, altered; signaling pathway regulation; autophagy, induced; cell differentiation, induced; apoptosis, inhibited 33510463; 33941660; 34145038; 34161773; 34233950; 34245780; 34433039; 34910106; 35613599; 36008706; 36113429 76 8 47 +IKZF1 Ikaros C2H2-type zinc finger protein; DNA-binding; Transcription factor Q13422 10320 7p12.2 human S393-p 451351 REASPSNsCQDSTDT cell cycle regulation; cell growth, induced 27026320 2 1 3 +RHOT1 RHOT1 EC 3.6.5.-; G protein; G protein, monomeric; G protein, monomeric, Rho; Hydrolase; Membrane protein, integral; Mitochondrial Q8IXI2 55288 17q11.2 human K182-ub 12255120 CPEEKEMkPACIKAL protein degradation; intracellular localization autophagy, induced 34152608 1 1 1 induces mitophagy by recruiting Parkin to mitochondria +NUP62 NUP62 Adaptor/scaffold; Nucleoporin P37198 23636 19q13.33 human T269-p 36440512 GAASGTStTTSTAAT protein degradation; phosphorylation signaling pathway regulation 30401435 1 0 0 induces phosphorylation of IRS1, regulates p38?/p62/mTORC1 pathway +SMAD4 SMAD4 DNA-binding; Nuclear receptor co-regulator; Transcription, coactivator/corepressor Q13485 4089 18q21.2 human T77-p 17478300 KCVTIQRtLDGRLQV MH1 molecular association, regulation transcription, altered DNA(DISRUPTS) 20974850 1 0 0 negatively regulates TGFbeta signaling +GRIA2 GluR2 Channel, calcium; Channel, ligand-gated; Membrane protein, integral; Membrane protein, multi-pass P42262 2891 4q32.1 human Y876-p 452173 YKEGYNVyGIESVKI molecular association, regulation neural plasticity GRIP1(DISRUPTS) 26109571; 32071234 9 5 109 +HDGF HDGF Cytokine; Transcription regulation P51858 3068 1q23.1 human K80-sm 3278903 FGKPNKRkGFSEGLW PWWP molecular association, regulation DNA(DISRUPTS) 18331345 1 3 0 +Rin1 Rin1 GEF; GEF, Rab Q921Q7 225870 19|19 A mouse Y120-p 2796501 PSFVSSHyIEESTGG molecular association, regulation Arg(INDUCES) 15886098 1 0 0 +KCNQ1 Kv7.1 Channel, potassium; Membrane protein, integral; Membrane protein, multi-pass P51787 3784 11p15.5-p15.4 human S409-p 456162 SHTLLSPsPKPKKSV activity, induced 12879210 1 3 0 +PTEN PTEN Carbohydrate Metabolism - inositol phosphate; EC 3.1.3.16; EC 3.1.3.48; EC 3.1.3.67; Motility/polarity/chemotaxis; Nuclear receptor co-regulator; PHOSPHATASE; Phosphatase, lipid; Tumor suppressor P60484 5728 10q23.31 human Y174-p 464091 TIPSQRRyVYYYSYL activity, inhibited 23995781 2 4 10 PTEN downregulation +IKZF1 Ikaros C2H2-type zinc finger protein; DNA-binding; Transcription factor Q13422 10320 7p12.2 human S361-p 14160239 LAEGTPRsNHSAQDS molecular association, regulation; intracellular localization cell differentiation, induced; transcription, induced DNA(INDUCES) 23071339 1 6 0 induces transcription of DNAJC6, EIF4e3, TNFAIP8L2; nuclear localization +DLC1 DLC1 GAP; GAP, Rac/Rho; Tumor suppressor Q96QB1 10395 8p22 human S642-p 37038504 DSFGSLPsPKELSSF activity, induced; intracellular localization; protein conformation carcinogenesis, inhibited; cell growth, inhibited; cell motility, inhibited talin 1(INDUCES); tensin 1 iso1(INDUCES) 25452387 1 3 0 localize to focal adhesions; activates Rho-GAP activity +Kcnj3 GIRK1 Channel, potassium; Membrane protein, integral; Membrane protein, multi-pass P63251 50599 3q21 rat Y67-p 3146602 LGSETSRyLSDLFTT IRK activity, inhibited 10833508 1 1 0 +Inpp5d SHIP EC 3.1.3.86; Motility/polarity/chemotaxis; Phosphatase, lipid Q9ES52 16331 1 D|1 44.44 cM mouse Y918-p 450030 NEMINPNyIGMGPFG molecular association, regulation SHC1(INDUCES); DOK1(INDUCES) 11031258; 9099679 3 9 175 +IP6K2 IHPK2 EC 2.7.4.21; Kinase, other; Motility/polarity/chemotaxis Q9UHH9 51447 3p21.31 human S359-p 478423 LEDLSEEsADESAGA IPK apoptosis, induced; cell growth, altered TRAF2(INDUCES) DNA(INDUCES) 17379600 1 1 0 induces NFkB-DNA binding +KLF13 KLF13 C2H2-type zinc finger protein; DNA-binding Q9Y2Y9 51621 15q13.3 human S123-p 40721822 APPSPAWsEPEPEAG protein degradation; ubiquitination 37029927 1 1 0 +MACF1 ACF7 Actin-binding; Cytoskeletal; Motility/polarity/chemotaxis Q9UPN3 23499 1p34.3 human S7222-p 18507012 FRSRGRRsKPSSRAA intracellular localization cell motility, induced; cytoskeletal reorganization 21295697 1 1 0 inhibits localization along microtubules, alters organization of microtubules, regulates skin wound repair, SC migration +DNM1L DRP1 Apoptosis; EC 3.6.5.5; Endoplasmic reticulum; Hydrolase; Microtubule-binding; Mitochondrial; Motor O00429 10059 12p11.21 human K594-sm 9859923 GNWRGMLkTSKAEEL activity, induced; intracellular localization 19638400 1 0 0 sumoylation is linked to its GTPase activity cycle, and influenced by DRP1 localization +RUNX1 AML1 iso8 DNA-binding; Oncoprotein; Transcription factor Q01196-8 861 21q22.12 human S276-p 454399 DTRQIQPsPPWSYDQ protein degradation; phosphorylation cell differentiation, induced 16046550; 17015473; 22531928 10 8 46 +Per2 PER2 Nuclear receptor co-regulator; Nucleolus; Transcription factor O54943 18627 1|1 D mouse S693-p 468399 ETVEDMAsGPESLDG carcinogenesis, induced; cell growth, induced 30746467 2 6 0 +LRRK2 LRRK2 EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, Ser/Thr (non-receptor); Protein kinase, TKL Q5S007 120892 12q12 human T1503-p 10426325 ALAKLRKtIINESLN molecular association, regulation; protein conformation; enzymatic activity, induced Other(INDUCES) 21806997 8 4 0 induces GTP binding, induces protein destabilization due to unfavourable conformation +Exoc8 EXOC8 Vesicle O54924 245709 19q12 rat S670-p 56663140 TFIRQNAsFLYDTVL molecular association, regulation exocytosis, inhibited Sec5(DISRUPTS); EXOC8(DISRUPTS) 28325821 1 2 0 +Traf6 TRAF6 EC 6.3.2.-; Ligase; UBIQUITIN LIGASE; Ubiquitin conjugating system; Ubiquitin ligase P70196 22034 2|2 E2 mouse K461-ub 1877141200 HEEVMDAkPELLAFQ signaling pathway regulation 32816906 1 0 0 important for ARC regulating TRAF6 Lys63-linked ubiquitination and the NF-kB signaling pathway +Rph3a rabphilin 3A Vesicle P47709 171039 12q16 rat S234-p 455904 GPPTRRAsEARMSTT intracellular localization 14-3-3 beta(INDUCES) 11466418; 22993210 5 0 2 hormone secretion +Pfn1 profilin 1 Actin-binding; Cytoskeletal; Motility/polarity/chemotaxis P62962 18643 11 B3|11 43.21 cM mouse T90-p 23135104 EFTMDLRtKSTGGAP Profilin molecular association, regulation; protein conformation cytoskeletal reorganization ACTB(INDUCES) 27228149 1 1 1 reduces overall actin polymerization in cells +CD6 CD6 Cell surface; Membrane protein, integral P30203 923 11q12.2 human S562-p 28095004 QYHPRSNsESSTSSG phosphorylation signaling pathway regulation 23711376 1 0 0 ERK1/2 phosphorylation, MAPK pathway activation +Pam PAM EC 1.14.17.3; EC 4.3.2.5; Lyase; Membrane protein, integral; Oxidoreductase; Vesicle P14925 25508 9q37 rat T946-p 455820 KGFDRVStEGSDQEK intracellular localization; enzymatic activity, induced 11524414; 20374556 2 4 0 +Cask CASK Adaptor/scaffold; EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, CAMK; Protein kinase, Ser/Thr (non-receptor) O70589 12361 X A1.1|X 8.43 cM mouse S51-p 1261103 DVAKFTSsPGLSTED Pkinase molecular association, regulation; intracellular localization liprin alpha 1(DISRUPTS) 18054859 1 3 0 promotes CASK recruitment to presynaptic membranes and interaction with presynaptic proteins (Veli, Mint1, neurexins, N-type voltage-gated calcium channels); ; promotes calcium influx into neurons; promotes synaptogenesis +Met Met EC 2.7.10.1; KINASE; Kinase, protein; Membrane protein, integral; Oncoprotein; Protein kinase, TK; Protein kinase, tyrosine (receptor) P16056 17295 6 A2|6 7.83 cM mouse Y1233-p 448471 DMYDKEYySVHNKTG PK_Tyr_Ser-Thr ubiquitination; enzymatic activity, induced carcinogenesis, induced; cell differentiation, induced; cell motility, induced; cell growth, induced 12244174; 19595710; 34580063; 37175792; 7708691 52 16 442 +AGO2 AGO2 EC 3.1.26.n2; RNA processing; RNA-binding Q9UKV8 27161 8q24.3 human Y529-p 17533104 LPGKTPVyAEVKRVG Piwi molecular association, regulation; intracellular localization; activity, inhibited carcinogenesis, induced; cell differentiation, induced DICER1(DISRUPTS) RNA(DISRUPTS) 21071408; 26443379; 26858302; 31981897; 35259248 5 1 0 +CHKB CHKB EC 2.7.1.32; EC 2.7.1.82; Kinase, other; Lipid Metabolism - glycerophospholipid Q9Y259 1120 22q13.33 human S40-p 3857922 PKRRRASsLSRDAER enzymatic activity, induced 27149373 1 7 4 +XRCC1 XRCC1 DNA repair, damage P18887 7515 19q13.31 human T358-p 143281205 PDWTRDStHLICAFA BRCT intracellular localization DNA repair, induced 28740101 1 1 0 recruitment of XRCC1 to DNA damage and binding to PARP1/PAR +RUNX1 AML1 iso8 DNA-binding; Oncoprotein; Transcription factor Q01196-8 861 21q22.12 human S48-p 452744 TPPSTALsPGKMSEA activity, induced; molecular association, regulation cell growth, induced; transcription, induced; cell growth, altered HDAC1(DISRUPTS); HDAC3(DISRUPTS) 18003885; 21059642 2 30 11 increases RUNX1 trans-activation; increases marrow progenitor proliferation +Smad3 SMAD3 DNA-binding; Nuclear receptor co-regulator; Transcription factor Q8BUN5 17127 9|9 C mouse T388-p 1243500 GAEYRRQtVTSTPCW MH2 activity, induced; intracellular localization 17991884 3 1 0 Nuclear translocation +Kcnn4 KCNN4 Channel, potassium; Membrane protein, integral; Membrane protein, multi-pass Q9QYW1 65206 1q21 rat T327-p 452144 AWMYYKHtRRKDSRA CaMBD activity, inhibited 15243742 2 0 0 +MECP2 MECP2 Transcription, coactivator/corepressor P51608 4204 Xq28 human S80-p 452713 AVPEASAsPKQRRSI molecular association, regulation apoptosis, altered; transcription, altered YB-1(INDUCES); SMC3(INDUCES) 19820693; 22615490 12 68 1 Phosphorylation of S80 and S229 leads to activation and repression of EGR2 expression. Phosphorylated S80 interacts with YB-1 in RNA dependent manner +Rps6ka1 p90RSK EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, AGC; Protein kinase, Ser/Thr (non-receptor); Translation Q63531 81771 5q36 rat S380-p 447990 HQLFRGFsFVATGLM Pkinase_C activity, induced; intracellular localization; phosphorylation; enzymatic activity, induced cell growth, induced; translation, induced 12618428; 35648763; 9430688 66 48 64 induces eEF2K phosphorylation +ATG16L1 ATG16L1 Adaptor/scaffold; Autophagy; Membrane protein, peripheral Q676U5 55054 2q37.1 human S278-p 15425208 PAGGLLDsITNIFGR protein stabilization autophagy, induced 28082356; 31126908 2 5 9 enhance cleavage of T300A ATG16L1 via phosphorylation on S278 +PRKAA2 AMPKA2 Autophagy; EC 2.7.11.1; EC 2.7.11.27; EC 2.7.11.31; KINASE; Kinase, protein; Protein kinase, CAMK; Protein kinase, Ser/Thr (non-receptor) P54646 5563 1p32.2 human K60-ub 27177169 RSLDVVGkIKREIQN Pkinase enzymatic activity, inhibited 31996460 1 1 0 +TIMELESS TIMELESS Transcription, coactivator/corepressor Q9UNS1 8914 12q13.3 human T1078-p 50613403 PPASGQEtFWRIPAK TIMELESS_C molecular association, regulation DNA repair, altered PARP1(DISRUPTS) 26456830 1 0 0 +Abcc9 ABCC9 Channel, potassium; Membrane protein, integral; Membrane protein, multi-pass; Transporter; Transporter, ABC family P70170 20928 6 G2|6 74.35 cM mouse S1351-p 483972 RTGSGKSsLSLAFFR ABC_tran activity, induced 17596331 1 0 0 +COPS5 COPS5 Adaptor/scaffold; DEUBIQUITINASE; EC 3.4.-.-; Nuclear receptor co-regulator; Protease; Transcription, coactivator/corepressor; Translation Q92905 10987 8q13.1 human S201-p 1827354807 KPPDEGPsEYQTIPL enzymatic activity, inhibited signaling pathway regulation 31950832 1 1 0 NFkB signaling pathway +Tbx21 TBX21 DNA-binding; Transcription factor Q9JKD8 57765 11|11 D mouse S508-p 458229 PSSGDSSsPAGAPSP molecular association, regulation NFkB-p65(INDUCES) 16275766 2 2 0 DNA binding activity of NFkB-p65 is reduced in the presence of T-bet +Fbp1 FBPase Carbohydrate Metabolism - fructose and mannose; Carbohydrate Metabolism - glycolysis and gluconeogenesis; Carbohydrate Metabolism - pentose phosphate pathway; EC 3.1.3.11; Mitochondrial; Phosphatase (non-protein) Q9QXD6 14121 13|13 B3 mouse S271-p 25292084 LYPANKKsPSGKLRL FBPase_C protein degradation; ubiquitination carcinogenesis, induced; cell growth, induced 36237339 1 1 1 +YWHAE 14-3-3 epsilon Adaptor/scaffold P62258 7531 17p13.3 human K118-ac 474724 AANTGESkVFYYKMK 14-3-3 molecular association, regulation SFRS6(DISRUPTS); PLEKHQ1(DISRUPTS); SFRS4(DISRUPTS); DOK3(DISRUPTS); TSC2(DISRUPTS); ARAF(DISRUPTS); LARP(DISRUPTS); SRm300(DISRUPTS); SF2(DISRUPTS); TSC22D1(DISRUPTS); GAB2(DISRUPTS); RAF1(DISRUPTS); VASP(DISRUPTS); HDAC4(DISRUPTS); TRA2B(DISRUPTS); GBF1(DISRUPTS) 19608861 0 5 2 +Plcl1 PLCL1 Phospholipase Q3USB7 227120 1|1 C1.2 mouse T94-p 453436 KCGGRKKtVSFSSMP molecular association, regulation PPP1CA(DISRUPTS) 15306641 1 7 5 +KCNC4 Kv3.4 Channel, potassium; Membrane protein, integral; Membrane protein, multi-pass Q03721 3749 1p13.3 human S9-p 451076 ISSVCVSsYRGRKSG Potassium_chann receptor inactivation, altered 9649584 1 0 0 +BAP1 BAP1 DEUBIQUITINASE; EC 3.4.19.12; Protease; Tumor suppressor; Ubiquitin conjugating system; Ubiquitin-specific protease Q92560 8314 3p21.1 human S597-p 482083 QGSQGSSsPVEKEVV intracellular localization DNA repair, induced 24347639 1 10 7 +IDH2 IDH2 Carbohydrate Metabolism - citrate (TCA) cycle; EC 1.1.1.42; Mitochondrial; Other Amino Acids Metabolism - glutathione; Oxidoreductase P48735 3418 15q26.1 human K384-ac 15291451 RGLEHRGkLDGNQDL Iso_dh enzymatic activity, inhibited 32457458 2 5 13 oncometabolite 2-hydroxyglutarate (2HG) production +YAP1 YAP1 Oncoprotein; Transcription, coactivator/corepressor P46937 10413 11q22.1 human K342-ub 603486520 PSTANSPkCQELALR protein degradation carcinogenesis, altered 36271031 1 2 0 +Zfp36 TTP DNA-binding; RNA-binding P22893 22695 7 A3-B1|7 16.72 cM mouse S178-p 451151 HVLRQSIsFSGLPSG activity, induced; protein stabilization; molecular association, regulation; intracellular localization; activity, inhibited translation, altered; transcription, induced 14-3-3 beta(INDUCES); CAF-1A(DISRUPTS); CAF-1B(DISRUPTS) 15014438; 16508015; 20595389; 26002976; 26019272; 31527197; 36961408 13 25 11 +POLH POLH DNA repair, damage; EC 2.7.7.7; Transferase Q9Y253 5429 6p21.1 human K328-sm 1877365912 CSKNFPGkTALATRE IMS_C intracellular localization; enzymatic activity, inhibited 32350109 1 1 0 +ACLY ACLY Carbohydrate Metabolism - citrate (TCA) cycle; EC 2.3.3.8; Lyase; Transferase P53396 47 17q21.2 human S455-p 448631 PAPSRTAsFSESRAD carcinogenesis, induced; signaling pathway regulation 26039450; 36269753 10 83 122 +GAREM2 FAM59B Unknown function Q75VX8 150946 2p23.3 human Y102-p 28850311 DVREPVRyFSSVEEV CABIT molecular association, regulation cell differentiation, induced; signaling pathway regulation GRB2(INDUCES) 24003223 1 0 0 +INSR INSR EC 2.7.10.1; KINASE; Kinase, protein; Membrane protein, integral; Protein kinase, TK; Protein kinase, tyrosine (receptor) P06213 3643 19p13.2 human S1332-p 451590 ENVPLDRsSHCQREE enzymatic activity, inhibited 8454604 2 0 0 +DBF4 DBF4 Cell cycle regulation; Protein kinase, regulatory subunit Q9UBU7 10926 7q21.12 human S502-p 23010417 FSTDNSGsQPKQKSD cell cycle regulation 22123827 1 0 0 DBF4 phosphorylaion is important for supressing DNA replication. +SOX10 SOX10 Cell development/differentiation; DNA-binding; Transcription factor P56693 6663 22q13.1 human K55-sm 3875804 PGELGKVkKEQQDGE Sox_N activity, induced; molecular association, regulation transcription, induced; transcription, inhibited EGR2(DISRUPTS); PAX3(DISRUPTS) 16494873; 29295999; 34087780 3 0 0 SOX10 sumoylation at K55 were essential for expression of SAMMSON induced by vemurafenib. +HEXIM1 HEXIM1 Motility/polarity/chemotaxis; Transcription factor O94992 10614 17q21.31 human Y274-p 5204763 FSETYERyHTESLQN HEXIM molecular association, regulation; intracellular localization transcription, inhibited CCNT1(DISRUPTS); CDK9(DISRUPTS); LARP7(DISRUPTS) 25900325 2 1 1 nuclear localization, inhibits proviral gene expression, inhibition of 7SK snRNP complex aassembly +Elk1 ELK1 DNA-binding; Transcription factor P41969 13712 X A1.3|X 16.45 cM mouse T369-p 22725901 TLTPVLLtPSSLPPS molecular association, regulation transcription, induced MED16(INDUCES); MED23(INDUCES); Trap100(INDUCES) 27738173 2 0 0 +TOB2 TOB2 Q14106 10766 22q13.2 human S163-p 22999102 PSFGQSPsPTFIPRS cell growth, inhibited 22252318 1 1 0 promote mRNA deadenylaion and decay and the ability to suppress proliferation +FOSL1 FRA1 DNA-binding; Transcription factor P15407 8061 11q13.1 human T217-p 1270902 LEPEALHtPTLMTTP protein stabilization cell motility, induced; transcription, induced 17371847; 27816489 2 0 0 +FSCN1 fascin Actin-binding; Cytoskeletal; Motility/polarity/chemotaxis Q16658 6624 7p22.1 human K250-ub 60122800 GKATKVGkDELFALE Fascin cytoskeletal reorganization 27879315 1 2 0 fascin bundling activity +AQP1 AQP1 Membrane protein, integral; Membrane protein, multi-pass; Transporter; Transporter, aquaporin family P29972 358 7p14.3 human T157-p 482806 VLCVLATtDRRRRDL MIP activity, induced; intracellular localization 17522053; 22334691 2 0 0 T157A/T239A double mutation inhibits AQP1 translocation to the plasma membrane following hypotonic exposure; phosphorylation by PKC increases ion currents and water permability of AQP1. +NPM/ALK NPM-ALK KINASE; Kinase, protein; Protein kinase, TK; Protein kinase, tyrosine (receptor) AAA58698 human Y664-p 27275123 TAPGAGHyEDTILKS cell growth, induced; transcription, induced 16469875; 17110082 4 2 2 +SMAD2 SMAD2 DNA-binding; Transcription factor Q15796 4087 18q21.1 human K39-ac 478912 EQNGQEEkWCEKAVK intracellular localization cell cycle regulation; cell growth, inhibited; transcription, induced; signaling pathway regulation 17478422; 29187201 2 1 0 +ACD ACD Adaptor/scaffold Q96AP0 65057 16q22.1 human S169-p 15407290 SNAGLSLsQLLDEMR molecular association, regulation TERT(INDUCES) 27396482 1 0 1 telomerase recruitment, telomere length regulation +Myocd myocardin Cell development/differentiation; Transcription factor Q8VIM5 214384 11|11 B3 mouse S628-p 3627510 VLSSTFLsPQCSPQH transcription, inhibited 16141410 1 0 0 +NFE2L2 NRF2 DNA-binding; Transcription factor Q16236 4780 2q31.2 human K506-ac 7106324 RDIRRRGkNKVAAQN bZIP_Maf molecular association, regulation transcription, induced DNA(INDUCES) 19273602 1 1 0 +Dlx5 DLX5 DNA-binding; Transcription factor P70396 13395 6 A1|6 2.83 cM mouse S217-p 1725301 SDPMACNsPQSPAVW transcription, induced 18056716 1 0 0 measured by Osx mRNA levels +Cavin1 PTRF Transcription initiation complex O54724 19285 11 D|11 63.95 cM mouse S42-p 452127 EEPSGTGsDELIKSD phosphorylation 21282370 1 26 1 regulates phosphorylation of HSL S557 (aka S563) and S651 (aka S660); regulates lipolysis in adipocytes +RIOK2 RIOK2 EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, Ser/Thr (non-receptor); Protein kinase, atypical Q9BVS4 55781 5q15 human S483-p 7446950 QYRTRTLsITSSGSA molecular association, regulation; intracellular localization cell growth, induced NOB1P(DISRUPTS) 34125833 1 5 1 +PRRG4 PRRG4 Membrane protein, integral Q9BZD6 79056 11p13 human Y189-p 1870790705 EDAGLPSyEQAVALT molecular association, regulation; ubiquitination; phosphorylation carcinogenesis, induced; cell motility, induced Src(INDUCES); NEDD4(INDUCES) 33037408 1 0 0 Robo1 ubiquitination; FAK phosphorylation +APP APP Apoptosis; Cell surface; Membrane protein, integral; Receptor, misc.; Transcription factor P05067 351 21q21.3 human Y757-p 448202 SKMQQNGyENPTYKF APP_amyloid molecular association, regulation GRB2(INDUCES); Abl(INDUCES); Src(INDUCES); PLCG1(INDUCES); GRB7(INDUCES); SHC2(INDUCES); PIN1(INDUCES); LYN(INDUCES); DAB1(INDUCES); PLCG2(INDUCES); NCK1(INDUCES); SHC3(INDUCES); SHC1(INDUCES); CRK(INDUCES) 19602287 14 20 864 +UCHL3 UCHL3 EC 3.4.19.12; Protease; Ubiquitin conjugating system P15374 7347 13q22.2 human S75-p 482705 EEEEKIKsQGQDVTS Peptidase_C12 molecular association, regulation; enzymatic activity, induced DNA repair, induced ubiquitin(INDUCES) 27941124; 36142702 2 3 3 RAD51 focus formation, HR, and radiosensitivity +PTPN1 PTP1B EC 3.1.3.48; Motility/polarity/chemotaxis; PHOSPHATASE; Phosphatase; Protein phosphatase, tyrosine (non-receptor) P18031 5770 20q13.13 human K347-sm 12004413 EDKDCPIkEEKGSPL enzymatic activity, inhibited signaling pathway regulation 17159996 1 0 0 insulin signaling +Trpv2 TRPV2 Channel, cation; Membrane protein, integral; Membrane protein, multi-pass Q9WUD2 29465 10q23 rat S6-p 29631548 __MTSASsPPAFRLE cell growth, induced 26416880 1 3 0 neurite outgrowth +TAGLN2 TAGLN2 Cytoskeletal; Motility/polarity/chemotaxis P37802 8407 1q23.2 human S145-p 31885453 ARDDGLFsGDPNWFP protein stabilization carcinogenesis, induced; cell growth, induced 30041673 1 3 0 essential for Kras- regulated cell proliferation +ASXL2 ASXL2 DNA-binding Q76L83 55252 2p23.3 human R639-m2 27269956 HPSQVSPrARFPVSI cell differentiation, inhibited; apoptosis, inhibited; transcription, inhibited MLL3(DISRUPTS) DNA(DISRUPTS) 36197977 1 2 1 CARM1 inhibition up-regulates apoptosis and differentiation related genes +Oprd1 DOR-1 GPCR, family 1; Membrane protein, integral; Membrane protein, multi-pass; Receptor, GPCR P32300 18386 4 D2.3|4 64.78 cM mouse Y318-p 452090 SSLNPVLyAFLDENF 7tm_1 activity, induced; receptor internalization, altered 10925143 1 0 0 +LAT LAT iso2 Adaptor/scaffold; Membrane protein, integral O43561-2 27040 16p11.2 human Y110-p 450202 GANSVASyENEEPAC LAT molecular association, regulation; phosphorylation transcription, altered GRB2(INDUCES) 11395491 1 1 1 leads to ERK phosphorylation, NF-AT transcription +FH fumarase Carbohydrate Metabolism - citrate (TCA) cycle; EC 4.2.1.2; Lyase; Mitochondrial; Tumor suppressor P07954 2271 1q43 human T236-p 49156200 IKIGRTHtQDAVPLT Lyase_1 molecular association, regulation H2AZ(INDUCES) DNA(INDUCES) 26237645 1 0 0 non-homologous end-joining, inhibits methylation +MEF2D MEF2D DNA-binding; Transcription factor Q14814 4209 1q22 human K267-m1 31094532 QLGAPSRkPDLRVIT molecular association, regulation cell differentiation, inhibited; transcription, inhibited DNA(DISRUPTS) 24078251 1 1 0 +Prkcz PKCZ EC 2.7.11.13; KINASE; Kinase, protein; Protein kinase, AGC; Protein kinase, Ser/Thr (non-receptor) P09217 25522 5q36 rat S186-p 3136104 TCRRHMDsVMPSQEP molecular association, regulation 14-3-3 beta(INDUCES); RAF1(INDUCES) 10620507 2 0 0 +CTNNB1 CTNNB1 Actin-binding; Cell adhesion; Motility/polarity/chemotaxis; Nuclear receptor co-regulator; Oncoprotein; Transcription factor P35222 1499 3p22.1 human S37-p 447582 YLDSGIHsGATTTAP protein degradation; protein stabilization; molecular association, regulation; ubiquitination; intracellular localization; activity, inhibited; neddylation cell cycle regulation; carcinogenesis, induced; carcinogenesis, inhibited; apoptosis, induced; cell growth, inhibited; transcription, induced; cell motility, inhibited; signaling pathway regulation; transcription, altered; cell adhesion, altered; cytoskeletal reorganization; transcription, inhibited; cell growth, altered CBLL1(INDUCES); TRAF2(DISRUPTS) 12000790; 12027456; 15829978; 17008323; 17018282; 19060929; 19061640; 19667122; 20300119; 20419129; 22025562; 22234184; 26908451; 31911618; 32041324; 32046730; 32210470; 33651074; 33832512; 34117362; 34290402; 34326276; 34749529; 35064015; 35065073; 35108540; 35320710; 35347116; 36575468; 36941998; 37369481; 37400529; 9312064 110 3 12 +Notch1 Notch 1 Membrane protein, integral; Motility/polarity/chemotaxis; Oncoprotein; Receptor, misc.; Transcription factor Q01705 18128 2 A3|2 18.91 cM mouse K2068-ac 18899509 EGSYETAkVLLDHFA Ank_2 protein stabilization; ubiquitination 21499261 1 1 0 +Nr5a1 STF-1 Nuclear receptor; Transcription, coactivator/corepressor P33242 26423 2 B|2 24.42 cM mouse K194-sm 2798300 AFSNRTIkSEYPEPY molecular association, regulation; activity, inhibited; phosphorylation signaling pathway regulation; transcription, altered; transcription, inhibited SRC-1(DISRUPTS); GEMIN3(INDUCES); CDK7(DISRUPTS) 15192080; 15713642; 19015234; 21820362; 24232453 9 0 0 E199A Increases NR5A1?s Interaction with CDK7 and SRC1 ; affects hedgehog signaling; inhibits STF-1 S203 phosphorylation and its activation +Trpv2 TRPV2 Channel, cation; Membrane protein, integral; Membrane protein, multi-pass Q9WUD2 29465 10q23 rat S47-p 12738661 QREDRNSsPQIKVNL cell growth, induced 26416880 1 6 0 neurite outgrowth +RASSF1 RASSF1 iso2 Tumor suppressor Q9NS23-2 11186 3p21.31 human S175-p 13258707 LKLVRPVsVPSSKKP molecular association, regulation apoptosis, inhibited TRAIL-R1(DISRUPTS); 14-3-3 zeta(INDUCES); 14-3-3 epsilon(INDUCES); TNF-R1(DISRUPTS); MOAP1(DISRUPTS) 20069457 1 0 0 +VDAC1 VDAC1 Channel, misc.; Membrane protein, integral; Mitochondrial P21796 7416 5q31.1 human T107-p 3181799 DSSFSPNtGKKNAKI Porin_3 protein stabilization 25296756 1 19 2 +Fli1 FLI1 DNA-binding; Oncoprotein; Transcription factor P26323 14247 9 A4|9 17.74 cM mouse S10-p 8046505 GTIKEALsVVSDDQS molecular association, regulation transcription, inhibited AML1(DISRUPTS) 19470763 1 2 0 inhibits megakaryocyte maturation +Cttn Cortactin Actin-binding; Cytoskeletal; Motility/polarity/chemotaxis Q60598 13043 7|7 F5 mouse Y497-p 57807006 GITAIALyDYQAAGD SH3_9 molecular association, regulation MTUS2(DISRUPTS) 27451391 1 0 0 Y497, Y499, Y541 are major residues for interaction +S100A11 S100A11 Calcium-binding; Cell cycle regulation; DNA replication P31949 6282 1q21.3 human T10-p 10888705 KISSPTEtERCIESL S_100 intracellular localization cell cycle regulation; cell growth, altered NCL(INDUCES) 10851017; 14623863 2 2 7 Nuclear translocation is mediated by T10 phosphorylation. Calcium induced growth inhibition is mediated by T10 and S94 phosphorylation.; induces nuclear localization at cell confluency +ATP7B ATP7B EC 3.6.3.54; Hydrolase; Membrane protein, integral; Membrane protein, multi-pass; Transporter; Transporter, ion channel; Vesicle P35670 540 13q14.3 human S1121-p 11267007 AHSERPLsAPASHLN Hydrolase protein stabilization; intracellular localization 21189263 1 1 0 protein trafficking +VTN VTN Cell adhesion; Motility/polarity/chemotaxis; Secreted; Secreted, signal peptide P04004 7448 17q11.2 human S397-p 452178 NQNSRRPsRATWLSL molecular association, regulation; protein conformation; phosphorylation SERPINE1(DISRUPTS) 11795878 4 0 0 decreases accessibility of CKII to phosphorylate VTN +CREBBP CBP ACETYLTRANSFERASE; Acetyltransferase; DNA-binding; EC 2.3.1.48; Motility/polarity/chemotaxis; Nuclear receptor co-regulator; Transcription, coactivator/corepressor Q92793 1387 16p13.3 human R601-me 478320 EHVTQDLrSHLVHKL KIX protein conformation 12795599 2 0 0 +Oprm1 MOR-1 GPCR, family 1; Membrane protein, integral; Membrane protein, multi-pass; Receptor, GPCR P42866 18390 10 A1|10 1.85 cM mouse T376-p 20727901 NTREHPStANTVDRT receptor internalization, induced; molecular association, regulation endocytosis, induced; signaling pathway regulation ARRB2(INDUCES) 21868358; 23239825; 30018083; 32234959 7 2 0 regulates B-arrestin signaling; endocytosis of MOR-1 +Gli2 GLI2 C2H2-type zinc finger protein; Oncoprotein; Transcription factor Q0VGT2 14633 1 E2.3|1 52.17 cM mouse R225-me 1877628101 RVTPRLSrKRALSIS molecular association, regulation signaling pathway regulation SUFU(DISRUPTS) 31000813 1 0 0 increases Shh signaling leading to prevention of cellular senescence +RUNX1 AML1 DNA-binding; Oncoprotein; Transcription factor Q01196 861 21q22.12 human K43-ac 459072 AGAALAGkLRSGDRS molecular association, regulation cell growth, induced; transcription, induced DNA(INDUCES) 14752096 1 4 10 transformation increased +CHRM2 mAChR M2 GPCR, family 1; Membrane protein, integral; Membrane protein, multi-pass; Receptor, GPCR P08172 1129 7q33 human S288-p 459104 ESSNDSTsVSAVASN 7tm_1 receptor internalization, altered 9162044 3 0 0 Mutation of S286 T287 S288 S290 to A caused a faster rate and a greater extent of receptor internalization after agonist stimulation (transients only, not observed in stables). Mutation of all 8 sites prevented internalization (in both transients and stables). +CDK2 CDK2 Cell cycle regulation; EC 2.7.11.22; KINASE; Kinase, protein; Protein kinase, CMGC; Protein kinase, Ser/Thr (non-receptor) P24941 1017 12q13.2 human T14-p 447738 VEKIGEGtYGVVYKA Pkinase protein stabilization; enzymatic activity, inhibited; protein conformation cell cycle regulation 12912980; 1396589; 15632290; 23671119 12 110 1499 required for recovery from replication stress; loss of inhibitory phosphorylation causes DNA damage +TP53BP1 53BP1 DNA repair, damage; Transcription, coactivator/corepressor Q12888 7158 15q15.3 human K1628-ac 1876695601 NLVEGKRkRRSNVSS molecular association, regulation; intracellular localization DNA repair, altered H2A.1(DISRUPTS) 29190394 1 1 0 acetylation status regulates recruitment to foci, acetylation promotes DNA end resection and HR +Clock CLOCK ACETYLTRANSFERASE; Acetyltransferase; DNA-binding; EC 2.3.1.48; Transcription factor O08785 12753 5 C3.3|5 40.63 cM mouse S845-p 23094535 LPRHRTDsLTDPSKV molecular association, regulation; intracellular localization transcription, induced 29588368 1 6 1 S845 mice have altered circadian gene expression in peripheral tissues; regulates nuclear translocation via binding to 14-3-3 +DGCR8 DGCR8 Nucleolus; RNA processing; RNA-binding Q8WYQ5 54487 22q11.21 human S35-p 34501609 QALPREQsPPPPLQT protein stabilization 24239349 0 3 0 +CGAS cGAS EC 2.7.7.86 Q8N884 115004 6q13 human K198-ac 1868968400 DHLLLRLkCDSAFRG transcription, induced 32345711 1 1 0 inducing cytokine expression +KAT5 Tip60 ACETYLTRANSFERASE; Acetyltransferase; EC 2.3.1.48; Nuclear receptor co-regulator; Nucleolus Q92993 10524 11q13.1 human K187-ac 52498002 VAAQPGRkRKSNCLG protein degradation; intracellular localization apoptosis, altered 25301942 1 0 0 HDAC3 increased the TIP60 half-life, and the ubiquitination level of TIP60, nuclear localization, cytoplasm and nucleus with HDAC3 expressed, TIP60 deacetylation increases its resistance to apoptosis +SH2D2A TSAd Adaptor/scaffold Q9NP31 9047 1q23.1 human Y280-p 449440 PKPSNPIyNEPDEPI molecular association, regulation Lck(INDUCES) 18541536 1 3 94 +GRIK2 GluR6 Channel, calcium; Channel, ligand-gated; Membrane protein, integral; Membrane protein, multi-pass Q13002 2898 6q16.3 human C858-pa 27247801 QLEKRSFcSAMVEEL sumoylation; intracellular localization; phosphorylation; palmitoylation endocytosis, altered 37868810 2 0 0 palmitoylation maintains surface expression and regulates agonist -induced internalisation +GLI1 GLI1 C2H2-type zinc finger protein; Oncoprotein; Transcription factor P08151 2735 12q13.3 human S116-p 1877717202 FINSRCTsPGGSYGH activity, induced; molecular association, regulation transcription, induced SUFU(DISRUPTS) 35831023 1 0 0 +ARID3A Bright Transcription factor Q99856 1820 19p13.3 human K398-sm 7780000 ITPAPKIkKEEDSAI molecular association, regulation transcription, induced E2F1(DISRUPTS) 19436740 1 0 0 +Kit Kit EC 2.7.10.1; KINASE; Kinase, protein; Membrane protein, integral; Oncoprotein; Protein kinase, TK; Protein kinase, tyrosine (receptor) P05532 16590 5 C3.3|5 39.55 cM mouse Y571-p 448014 EEINGNNyVYIDPTQ activity, induced; molecular association, regulation cell motility, altered; cell growth, altered GAB2(INDUCES); SOCS6(INDUCES); SHC1(INDUCES); SHP-2(INDUCES); LNK(INDUCES) 14707129; 16873377; 18753636 13 3 18 +ATG13 ATG13 Autophagy; Vesicle O75143 9776 11p11.2 human S44-p 1869357207 ICTRSSSsPTGSDWF cell cycle regulation; autophagy, induced; cell growth, induced 32516310 1 1 0 +CCDC50 CCDC50 Inhibitor Q8IVM0 152137 3q28 human Y145-p 454594 RAYADSYyYEDGGMK molecular association, regulation EGFR(INDUCES) 16803894 1 12 21 inhibits the down-regulation of EGFR +Gsk3b GSK3B EC 2.7.11.1; EC 2.7.11.26; KINASE; Kinase, protein; Protein kinase, CMGC; Protein kinase, Ser/Thr (non-receptor) Q9WV60 56637 16|16 B3 mouse T356-p 37043704 KLPNGRDtPALFNFT enzymatic activity, inhibited; phosphorylation cell differentiation, induced; transcription, induced 25477508 1 0 0 decreased phosphorylation of Tau at Thr-212, obesity-resistant phenotype; NFAT transcription induced +Atxn1 ataxin-1 Nuclear export; RNA-binding P54254 20238 13 A5|13 21.98 cM mouse K585-ub 40320205 AEISNDLkIDSSTVE AXH protein degradation; intracellular localization 25641559 1 1 0 induces cytoplasmic-aggregate formation from decreased UBE2E1-mediated degradation +Pklr PKLR iso2 Carbohydrate Metabolism - glycolysis and gluconeogenesis; Carbohydrate Metabolism - pyruvate; EC 2.7.1.40; Kinase, other; Nucleotide Metabolism - purine P12928-2 24651 2q34 rat S12-p 1218250 AGYLRRAsVAQLTQE molecular association, regulation; enzymatic activity, inhibited; protein conformation PKLR iso2(DISRUPTS) 19320443; 22878931 5 1 6 Mutations at position 9 and 10 changed affected enzyme activity and decreased binding of the substrate phoenolpyruvate, but not another substrate ADP. +BUB1 BUB1 Cell cycle regulation; EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, Other; Protein kinase, Ser/Thr (non-receptor) O43683 699 2q13 human S969-p 20722066 FTAKCETsGFQCVEM Pkinase enzymatic activity, induced 26658523 1 2 0 +Plin1 perilipin 1 Lipid-binding Q8CGN5 103968 7|7 D2 mouse S492-p 459628 EKPARRVsDSFFRPS activity, induced; molecular association, regulation; intracellular localization cytoskeletal reorganization ABHD5(DISRUPTS) 16488886; 17114792; 19116774; 19850935; 23825572 12 12 0 when S517 is phosphorylated, S492 phosphorylation enhances PKA-stimulated lipolysis in adipocytes; phosphorylation of site facilitates lipolysis of lipid droplets.; induces dissociation of ABHD5 from perilipin and its association with Atgl; hosphorylation of S492 induces scattering of lipid droplets throughout the cytoplasm. ; induces Cytoplasmic Lipid Droplet (CLD) dispersion +Kcnj3 GIRK1 Channel, potassium; Membrane protein, integral; Membrane protein, multi-pass P63251 50599 3q21 rat S385-p 4706226 NSKERHNsVECLDGL activity, induced 19765080 3 4 1 +DPYSL2 CRMP-2 iso3 Microtubule-binding; Motility/polarity/chemotaxis NP_001184222 1808 8p21.2 human T619-p 454386 SVTPKTVtPASSAKT carcinogenesis, altered; cell motility, altered 24036111 33 36 35 +MIP AQP0 Channel, misc.; Membrane protein, integral; Membrane protein, multi-pass; Transporter, aquaporin family P30301 4284 12q13.3 human S235-p 450116 KSISERLsVLKGAKP molecular association, regulation; protein conformation Calmodulin(DISRUPTS) 18081321; 27660387 6 9 0 phosphorylation of AQP0 disrupts calcium sensitivity by altering the AQP0-CaM interaction interface +Mknk1 Mnk1 EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, CAMK; Protein kinase, Ser/Thr (non-receptor); Translation O08605 17346 4|4 D1 mouse S203-p 11507613 SGVKLNNsCTPITTP Pkinase enzymatic activity, induced 16162500 1 0 0 +INSR INSR EC 2.7.10.1; KINASE; Kinase, protein; Membrane protein, integral; Protein kinase, TK; Protein kinase, tyrosine (receptor) P06213 3643 19p13.2 human S1216-p 3103704 KDGVFTTsSDMWSFG PK_Tyr_Ser-Thr enzymatic activity, induced 10866039 1 0 0 +Jak3 JAK3 EC 2.7.10.2; KINASE; Kinase, protein; Protein kinase, TK; Protein kinase, tyrosine (non-receptor) Q62137 16453 8 B3.3|8 34.43 cM mouse Y820-p 1876350204 FEERHLKyISLLGKG PK_Tyr_Ser-Thr molecular association, regulation; phosphorylation cell growth, inhibited; transcription, inhibited STAT5A(DISRUPTS) 35192696 2 0 0 inhibits autophosphorylation and STAT5 phosphorylation +Pawr PAR-4 Apoptosis Q62627 64513 7q21 rat S124-p 28030293 GDEEEPDsAPEKGRS apoptosis, inhibited; transcription, induced 24457960 1 3 0 +Oxsr1 OSR1 EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, STE; Protein kinase, Ser/Thr (non-receptor) Q6P9R2 108737 9|9 F3 mouse S325-p 456504 VRRVPGSsGRLHKTE enzymatic activity, induced; phosphorylation 24808538; 34289367 14 12 0 +LONP1 PRSS15 DNA-binding; EC 3.4.21.-; Mitochondrial; Protease; RNA-binding P36776 9361 19p13.3 human S181-p 1869121003 NESDVVEsLDEIYHT LON_substr_bdg enzymatic activity, induced carcinogenesis, inhibited 31406245 1 1 0 regulation of mitochondrial bioenergetics +Cftr CFTR Channel, chloride; EC 3.6.3.49; Hydrolase; Membrane protein, integral; Membrane protein, multi-pass; Transporter; Transporter, ABC family P26361 12638 6 A2|6 8.1 cM mouse S659-p 11929100 QFTEERRsSILTETL CFTR_R protein conformation 19927121 0 1 0 in vitro +Tp53 p53 Activator; DNA-binding; Motility/polarity/chemotaxis; Nuclear receptor co-regulator; Transcription factor; Tumor suppressor P10361 24842 10q24 rat K379-ac 458983 GQSTSRHkKPMIKKV autophagy, induced 23055316 35 6 0 paraplegia +ARAF ARAF EC 2.7.11.1; KINASE; Kinase, protein; Oncoprotein; Protein kinase, Ser/Thr (non-receptor); Protein kinase, TKL P10398 369 Xp11.3 human Y302-p 455522 GYRDSGYyWEVPPSE activity, induced 9020159 1 6 91 +Ndufa10 NDUFA10 EC 1.6.5.3; EC 1.6.99.3; Energy Metabolism - oxidative phosphorylation; Mitochondrial; Oxidoreductase Q99LC3 67273 1|1 D mouse S250-p 32001601 KTFLPKMsEMCEVLV dNK enzymatic activity, induced apoptosis, inhibited; signaling pathway regulation 24652937 2 1 0 ATP synthesis and mitochondria were rescued; phosphorylation rescued ubiquinone reductase activity of Complex I, maintained neurotransmitter release at NMJ +CEP68 CEP68 Cytoskeletal Q76N32 23177 2p14 human S332-p 37046602 ADPVLQDsGVDLDSF protein degradation cytoskeletal reorganization 25503564 1 1 0 Centriole separation +Gab2 GAB2 Adaptor/scaffold Q9Z1S8 14389 7|7 E1 mouse S591-p 62877800 PVPSGTNsPAPKKST molecular association, regulation PIK3R1(DISRUPTS) 28096188 1 0 0 +OSBP OSBP Lipid-binding P16258 rabbit S242-p 484804 TALQRSLsELESLKL intracellular localization exocytosis, inhibited 20444975 2 45 16 impairment of CERT translocation to the Golgi; promotes Golgi fragmentation +EYA3 EYA3 EC 3.1.3.48; PHOSPHATASE; Protein phosphatase, tyrosine (non-receptor) Q99504 2140 1p35.3 human Y96-p 1869778704 AYPGQTQyQTLQQTQ cell growth, altered 31847183 1 0 0 +GBF1 GBF1 GEF; GEF, ARF Q92538 8729 10q24.32 human T1338-p 454448 GKIHRSAtDADVVNS intracellular localization cell cycle regulation 23418352 4 17 31 attenuates membrane association; required for mitosis +PRLR PRLR Membrane protein, integral; Receptor, cytokine P16471 5618 5p13.2 human S349-p 451641 YLDPDTDsGRGSCDS receptor internalization, induced; protein degradation; molecular association, regulation; ubiquitination; phosphorylation cell motility, altered; transcription, altered; cell growth, altered BTRC(INDUCES); FBW1B(INDUCES) 15082796; 16278670; 18252943; 19276348 4 0 0 +Ezr Ezrin Cytoskeletal; Motility/polarity/chemotaxis P26040 22350 17|17 A1 mouse T235-p 449293 YEKDDKLtPKIGFPW FERM_C activity, induced; intracellular localization cytoskeletal reorganization 12769842 1 0 0 The expression of activated variants of ezrin T234D,T566D) did induce a morphological reminiscent of the senescent phenotype. +SIT1 SIT Adaptor/scaffold; Membrane protein, integral Q9Y3P8 27240 9p13.3 human Y148-p 451883 GPGTPVKySEVVLDS molecular association, regulation SHP-2(INDUCES) 10209036 2 7 221 +Prkce PKCE EC 2.7.11.13; KINASE; Kinase, protein; Protein kinase, AGC; Protein kinase, Ser/Thr (non-receptor) P16054 18754 17|17 E4 mouse T710-p 450184 TREEPILtLVDEAII Pkinase_C enzymatic activity, induced 12640464 3 24 33 +CACB CACNA1C Channel, calcium; Membrane protein, integral; Membrane protein, multi-pass P15381 100101555 rabbit S1829-p 451189 EGHGSPLsPAVRAQE CAC1F_C activity, induced 15044319 1 1 0 +SIPA1L1 SIPA1L1 GAP; GAP, Ras O43166 26037 14q24.2 human S1632-p 3892364 SLPLRRPsYTLGMKS SPAR_C molecular association, regulation PSD-95(INDUCES) 22117215 1 16 63 Fluorescence Polarization +PPP1R16B PPP1R16B Motility/polarity/chemotaxis; Protein phosphatase, regulatory subunit Q96T49 26051 20q11.23 human S333-p 486244 LRHKSSLsRRTSSAG phosphorylation 31315927 2 1 0 increases phosphorylation of MLC2 +PLK4 PLK4 EC 2.7.11.21; KINASE; Kinase, protein; Nucleolus; Protein kinase, Other; Protein kinase, Ser/Thr (non-receptor) O00444 10733 4q28.1 human K45-ac 62518203 VAIKMIDkKAMYKAG Pkinase enzymatic activity, inhibited; protein conformation; phosphorylation cell cycle regulation 27796307 1 1 0 inhibits phosphorylation of its kinase domain, prevents centrosome amplification +Dynlt1 DYNLT1 Microtubule-binding; Motility/polarity/chemotaxis; Motor P51807 21648 17 A1|17 3.97 cM mouse T94-p 456225 SSTDGSCtVRWENKT Tctex-1 activity, induced; molecular association, regulation; intracellular localization cell cycle regulation; cell growth, induced; cell differentiation, induced; cytoskeletal reorganization ARHGEF2(INDUCES); DYNC1I1(DISRUPTS) 22405273; 23954591 7 0 0 ciliary resorption; T94 phosphorylation promotes proliferation of neural progenitors through modulation of ciliary resorption and G1 length. +CARD11 CARD11 Adaptor/scaffold Q9BXL7 84433 7p22.2 human K696-ub 27738302 GSFVHSVkPGSLAEK transcription, induced 23322406 1 0 0 induces NF-kB activation +Syngap1 SynGAP GAP; GAP, Ras Q9QUH6 192117 20p12 rat S1138-p 451016 PSITKQHsQTPSTLN DUF3498 activity, induced; molecular association, regulation; intracellular localization PSD-95(DISRUPTS) 14970204; 25569349 3 2 0 SynGAP dispersion from dendritic spines, Ras activity and GluA1 tafficking during LTP +PLK1 PLK1 EC 2.7.11.21; KINASE; Kinase, protein; Protein kinase, Other; Protein kinase, Ser/Thr (non-receptor) P53350 5347 16p12.2 human K191-m2 1879760600 LNEDLEVkIGDFGLA enzymatic activity, inhibited cell cycle regulation; cytoskeletal reorganization 31863092 1 0 0 control of PLK1 activity at kinetochores, kinetochore-microtubule attachments, spindle microtubule dynamics during mitosis +Rufy3 RUFY3 Cell development/differentiation Q9D394 52822 5 E1|5 43.77 cM mouse S34-p 4775177 YLCKFRVsMDGEWLC protein stabilization; enzymatic activity, inhibited; activity, inhibited cytoskeletal reorganization 31221560 1 6 3 protects axons from degeneration, inhibits activity of itself and of DEVDase +Cebpa C/EBP-alpha DNA-binding; Transcription factor P53566 12606 7 B2|7 21.02 cM mouse T226-p 449825 GHPTPPPtPVPSPHA transcription, induced; transcription, inhibited 10567568; 17290224 8 0 0 +BTLA BTLA Membrane protein, integral Q7Z6A9 151888 3q13.2 human Y257-p 454099 ENKPGIVyASLNHSV phosphorylation signaling pathway regulation 32437509 2 1 6 inhibits IL2 production, phosphorylation of CD3Z and CD28, and hence T cell signaling +Prkaa1 AMPKA1 Autophagy; EC 2.7.11.1; EC 2.7.11.26; EC 2.7.11.27; EC 2.7.11.31; KINASE; Kinase, protein; Protein kinase, CAMK; Protein kinase, Ser/Thr (non-receptor) Q5EG47 105787 15|15 A1 mouse T183-p 448786 SDGEFLRtSCGSPNY Pkinase protein degradation; intracellular localization; phosphorylation; enzymatic activity, induced carcinogenesis, induced; autophagy, induced; cell growth, induced; apoptosis, inhibited; cytoskeletal reorganization; transcription, altered; cell growth, altered AMPKA1(INDUCES) 11549258; 11994296; 12456889; 14985505; 17482548; 17525164; 18202101; 19176702; 19942859; 21478880; 24563466; 24928508; 33531625; 33779513; 35256937 228 16 33 +KHDRBS1 KHDRBS1 RNA-binding Q07666 10657 1p35.2 human R325-m1 476704 PVRGAITrGATVTRG intracellular localization 12529443 1 5 37 +DLG1 DLG1 Adaptor/scaffold; Motility/polarity/chemotaxis Q12959 1739 3q29 human T209-p 35547401 VNTDSLEtPTYVNGT MAGUK_N_PEST molecular association, regulation; intracellular localization cytoskeletal reorganization GKAP1(DISRUPTS) 15729360 1 1 0 +TUBA1C TUBA1C Cytoskeletal; Motility/polarity/chemotaxis Q9BQE3 84790 12q13.12 human S165-p 8046500 SVDYGKKsKLEFSIY Tubulin activity, induced; intracellular localization; protein conformation cell motility, induced; cell motility, altered; cytoskeletal reorganization 19406749; 24574051; 35799350 3 0 1 +MOB1A MOB1A Protein kinase, regulatory subunit Q9H8S9 55233 2p13.1 human T12-p 34669905 FSSRSSKtFKPKKNI activity, induced; molecular association, regulation; protein conformation; phosphorylation signaling pathway regulation NDR1(INDUCES); MST2(INDUCES); LATS1(INDUCES); MST1(DISRUPTS) 26108669; 28373297; 32513747 3 2 3 Mst2 binding to Mob1 suffices to activate Mob1for Lats1 binding.; Fluorescence polarization ; induces YAP1 phosphorylation, manipulates the conserved Hippo pathway +EPHA2 EphA2 EC 2.7.10.1; KINASE; Kinase, protein; Membrane protein, integral; Protein kinase, TK; Protein kinase, tyrosine (receptor) P29317 1969 1p36.13 human S892-p 3189622 ADFDPRVsIRLPSTS signaling pathway regulation 32413552 1 13 58 MEK-ERK-RSK signaling +PAPOLA PAP-alpha EC 2.7.7.19; RNA processing; RNA splicing; Transferase P51003 10914 14q32.2 human K650-ac 466633 PTPIVGVkRTSSPHK molecular association, regulation; intracellular localization CPSF6(DISRUPTS); CFIM25(DISRUPTS) 17172643 1 3 17 cytoplasmic localization +TRIM29 TRIM29 Transcription factor; UBIQUITIN LIGASE; Ubiquitin ligase Q14134 23650 11q23.3 human S550-p 31836501 GYPSLMRsQSPKAQP molecular association, regulation DNA repair, induced; apoptosis, inhibited; transcription, inhibited RNF8(INDUCES); DVL2(DISRUPTS) 24469230; 26381412 2 0 0 +DDX5 DDX5 EC 3.6.4.13; Helicase; Nuclear receptor co-regulator; Nucleolus; RNA splicing; RNA-binding; Spliceosome P17844 1655 17q23.3 human K43-ac 15211501 NPGEKLVkKKWNLDE protein stabilization; molecular association, regulation carcinogenesis, induced; transcription, induced HDAC1(INDUCES); HDAC2(INDUCES) 20663877 1 1 0 +Mdm4 MDM4 EC 6.3.2.-; Ligase; UBIQUITIN LIGASE; Ubiquitin conjugating system; Ubiquitin ligase O35618 17248 1 E4|1 57.75 cM mouse S367-p 457676 PDCRRTIsAPVVRPK protein degradation; molecular association, regulation cell cycle regulation; apoptosis, inhibited; signaling pathway regulation 14-3-3 gamma(INDUCES) 17823617; 19573810; 22556425; 24190973 21 11 2 +FUS hnRNP P2 DNA-binding; Nuclear receptor co-regulator; Oncoprotein; RNA splicing; RNA-binding; SUMO LIGASE P35637 2521 16p11.2 human S183-p 1878186706 NYGQDQSsMSSGGGS molecular association, regulation hnRNP P2(DISRUPTS) 35753345 1 1 0 +Steap4 STEAP4 EC 1.16.1.-; Membrane protein, integral; Membrane protein, multi-pass; Oxidoreductase Q923B6 117167 5|5 A1 mouse K97-ub 8084100 TELVDYLkGKVLVDV F420_oxidored protein degradation 35747386 1 1 1 +Mef2a MEF2A DNA-binding; Motility/polarity/chemotaxis; Transcription factor Q2MJT0 309957 1q22 rat S192-p 7533201 ATLHRNVsPGAPQRP activity, induced apoptosis, inhibited; transcription, induced 17630987 1 1 0 +MITF MITF iso9 DNA-binding; Oncoprotein; Transcription factor O75030-9 4286 3p13 human S298-p 448503 QARAHGLsLIPSTGL DUF3371 activity, induced transcription, altered 10587587 2 1 0 +Mastl MASTL EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, AGC; Protein kinase, Ser/Thr (non-receptor) Q8C0P0 67121 2|2 A3 mouse T206-p 18012011 PKQDYSRtPGQVLSL intracellular localization 24101512 1 2 0 export to the cytoplasm +FOXA1 FOXA1 DNA-binding; Transcription factor P55317 3169 14q21.1 human K295-me 1881209000 KGGPESRkDPSGASN protein stabilization; molecular association, regulation; methylation cell cycle regulation; carcinogenesis, induced; cell growth, induced USP7(INDUCES) 33827814 1 0 0 methylation prevents it's ubiquitylation and increases protein stability, androgen-dependent prostate cancer (PACa) growth +CREB1 CREB DNA-binding; Transcription factor P16220 1385 2q33.3 human S100-p 451809 ESEDSQEsVDSVTDS pKID molecular association, regulation; phosphorylation CBP(INDUCES) 17209043 8 1 1 mutation to alanine decreases S121 phosphorylation in cells treated with ionizing radiation +Asap1 DDEF1 GAP; GAP, ARF; Motility/polarity/chemotaxis Q9QWY8 13196 15|15 D1 mouse Y308-p 450437 PKEVGGLyVASRANS molecular association, regulation; activity, inhibited Pyk2(INDUCES) Other(DISRUPTS) 12771146; 16413287 2 0 1 leads to less binding to phospholipids (including P(4,5)P2, PI(3,4,5)P3, and PI(3,4)P2) and less GAP activity toward Arf1 +IFI16 IFI16 Transcription factor Q16666 3428 1q23.1 human K6-ub 964520238 __MGKKYkNIVLLKG protein degradation signaling pathway regulation STING(INDUCES) 31665637 1 2 0 IFI16 degradation inhibits viral DNA-induced IFN-I production +EGFR EGFR EC 2.7.10.1; KINASE; Kinase, protein; Membrane protein, integral; Oncoprotein; Protein kinase, TK; Protein kinase, tyrosine (receptor) P00533 1956 7p11.2 human T678-p 448053 RHIVRKRtLRRLLQE receptor internalization, induced; protein degradation; molecular association, regulation; receptor recycling, induced; enzymatic activity, inhibited; phosphorylation; receptor desensitization, altered; intracellular localization; receptor internalization, altered; protein conformation; receptor recycling, altered carcinogenesis, induced; cell adhesion, induced; cytoskeletal reorganization; signaling pathway regulation GRB2(INDUCES); G-alpha(s)(DISRUPTS); KPNA1(INDUCES); EGFR(INDUCES); SLC5A1(INDUCES); PKCA(NOT_REPORTED); Calmodulin(DISRUPTS) 10816576; 11185568; 12359306; 1556153; 16793002; 17942932; 18037521; 18042729; 1860884; 20692258; 23205726; 3379075; 34155348; 35791809 22 0 0 +ARAP3 ARAP3 GAP; GAP, ARF; Motility/polarity/chemotaxis Q8WWN8 64411 5q31.3 human Y1408-p 454958 PVYEEPVyEEVGAFP molecular association, regulation carcinogenesis, altered; cell motility, altered; cell adhesion, altered VAV2(INDUCES); TARP(INDUCES) 21076469; 22750419 3 1 3 suppresses peritoneal dissemination of scirrhous gastric carcinoma cells +FOXP3 FOXP3 C2H2-type zinc finger protein; Cell cycle regulation; DNA-binding; Transcription factor Q9BZS1 50943 Xp11.23 human K31-ac 25614402 PSWRAAPkASDLLGA protein stabilization 23644046 2 1 0 +Fyn Fyn EC 2.7.10.2; KINASE; Kinase, protein; Oncoprotein; Protein kinase, TK; Protein kinase, tyrosine (non-receptor) Q62844 25150 20q12 rat Y420-p 447882 RLIEDNEyTARQGAK PK_Tyr_Ser-Thr enzymatic activity, induced 19625508 31 94 3048 +Rcan1 RCAN1 Inhibitor Q9JHG6 54720 16 C4|16 53.6 cM mouse T206-p 21511700 LHAATDTtPSVVVHV Calcipressin molecular association, regulation PPP3CA(DISRUPTS) 22864830 2 1 0 +MCRS1 MCRS1 Nuclear receptor co-regulator; Nucleolus; RNA-binding Q96EZ8 10445 12q13.12 human S35-p 14575930 LAGQKRAsSQALGTI cell cycle regulation; cytoskeletal reorganization 27192185 1 3 1 K-fiber formation and dynamics +Ms4a2 FcER1B Membrane protein, integral; Membrane protein, multi-pass; Receptor, misc. P13386 25316 1q43 rat Y224-p 2883703 LYEELHVySPIYSAL molecular association, regulation GRB2(INDUCES); SHIP(INDUCES); Syk(INDUCES); SHC1(INDUCES); SHP-1(INDUCES) 17365510 1 1 0 SHIP binding is senstive to the presence of Syk. +SMAD3 SMAD3 DNA-binding; Nuclear receptor co-regulator; Transcription factor P84022 4088 15q22.33 human S418-p 6845003 LTQMGSPsIRCSSVS protein degradation; ubiquitination; intracellular localization; activity, inhibited cell growth, inhibited; signaling pathway regulation 18760948; 18794808 2 1 0 nuclear translocation; destabilizes the activated Smad3 and inhibits TGF-beta signaling +SOX2 SOX2 Cell development/differentiation; DNA-binding; Transcription factor P48431 6657 3q26.33 human T116-p 17490601 KYRPRRKtKTLMKKD SOXp protein degradation; protein stabilization UBR5(DISRUPTS) 30894683 2 0 0 AKT1 phosphorylation at T116 blocks UBR5-induced ubiquitination at K115 of SOX2; AKT protects SOX2 from UBR5, TRIM3, and CUL9-mediated degradation +RARA RARA DNA-binding; Nuclear receptor; Oncoprotein; Transcription factor P10276 5914 17q21.2 human S369-p 451381 YVRKRRPsRPHMFPK Hormone_recep protein degradation; acetylation; molecular association, regulation; intracellular localization; activity, inhibited; protein conformation; phosphorylation chromatin organization, altered; cell differentiation, induced; transcription, induced; transcription, inhibited; signaling pathway regulation SMRT(DISRUPTS); RARA iso2(INDUCES); CCNH(INDUCES); RXRA(DISRUPTS); GTF2H1(INDUCES) DNA(INDUCES) 16769902; 19078967; 20215566; 23382200; 23637584; 27419624 8 0 0 +PTPN7 HePTP EC 3.1.3.48; Motility/polarity/chemotaxis; PHOSPHATASE; Protein phosphatase, tyrosine (non-receptor) P35236 5778 1q32.1 human S93-p 448310 ALQRQPPsPKQLEEE molecular association, regulation; protein conformation ERK2(DISRUPTS); P38A(DISRUPTS) 10206983; 16226275 3 9 1 +H3c1 H3 DNA-binding P68433 360198 13|13 A3.1 mouse S10-p 455676 TKQTARKsTGGKAPR Histone molecular association, regulation chromatin organization, altered; transcription, induced; transcription, inhibited; transcription, altered; cell growth, altered 14-3-3 zeta(INDUCES); 14-3-3 epsilon(INDUCES); CBX4(DISRUPTS); CBX1(DISRUPTS); CBX3(DISRUPTS); HP1 alpha(DISRUPTS); CBX8(DISRUPTS); CBX7(DISRUPTS); CBX1(INDUCES) DNA(INDUCES) 10899125; 11242053; 16222246; 17590163; 18381464; 19109180; 19264835; 19859561; 19965984; 20067909; 20129940; 24430871; 26051938; 33761914 241 15 1 +ABL2 Arg EC 2.7.10.2; KINASE; Kinase, protein; Oncoprotein; Protein kinase, TK; Protein kinase, tyrosine (non-receptor) P42684 27 1q25.2 human Y439-p 447923 RLMTGDTyTAHAGAK PK_Tyr_Ser-Thr protein degradation 15735735 4 39 1640 +RB1CC1 RB1CC1 Autophagy; DNA-binding; Transcription factor; Tumor suppressor Q8TDY2 9821 8q11.23 human K276-ac 1883544403 TADAESGkEIRESCQ protein stabilization 36394358 1 1 0 Puncta formation of RB1CC1, autophagosome formation +Trpc6 TRPC6 Channel, cation; Membrane protein, integral; Membrane protein, multi-pass Q61143 22068 9 A1|9 2.46 cM mouse S448-p 15794302 KFVAHAAsFTIFLGL TM; Ion_trans activity, inhibited 20961851 1 0 0 +Ptprh PTPRH EC 3.1.3.48; Membrane protein, integral; Motility/polarity/chemotaxis; PHOSPHATASE; Receptor protein phosphatase, tyrosine E9Q0N2 545902 7|7 A1 mouse Y945-p 14312603 LVPEEAMyENVASLV molecular association, regulation cytoskeletal reorganization GRB2(INDUCES); Fyn(INDUCES) 20398064 1 0 0 +TNNI3 TNNI3 Actin-binding; Motility/polarity/chemotaxis; Motor P19429 7137 19q13.42 human S166-p 3146609 LGARAKEsLDLRAHL Troponin molecular association, regulation TNNC1(DISRUPTS) 11121119 1 3 0 +EIF1 EIF1 Translation; Translation initiation P41567 10209 17q21.2 human T72-p 34404300 KKFACNGtVIEHPEY SUI1 translation, induced 24898249 1 1 0 ZFAND2A translation +RECQL4 RECQL4 EC 3.6.4.12; Helicase O94761 9401 8q24.3 human K382-ac 7106305 RKQAWKQkWRKKGEC intracellular localization 19299466 1 0 0 accumulates in the cytoplasm +HSPA5 GRP78 Chaperone; Heat shock protein; KINASE P11021 3309 9q33.3 human K633-ac 13362605 IVQPIISkLYGSAGP HSP70 molecular association, regulation; phosphorylation apoptosis, induced; signaling pathway regulation PERK(DISRUPTS) 20371724 1 1 0 induces phosphorylation of elf2a and activation of eIf2a-ATF4-CHOP pathway +Creb1 CREB iso1 DNA-binding; Transcription factor Q01147-1 12912 mouse K304-sm 12063904 ARECRRKkKEYVKCL bZIP_1 cell differentiation, inhibited; transcription, induced 31433978 2 0 0 +KCNQ4 KCNQ4 Membrane protein, integral; Membrane protein, multi-pass P56696 9132 1p34.2 human T552-p 13301700 AKRKFKEtLRPYDVK KCNQ_channel activity, inhibited 20147557 1 0 0 mediates AKAP79 sensitization to inhibition by muscarinic receptor stimulation +Oprm1 MOR-1 GPCR, family 1; Membrane protein, integral; Membrane protein, multi-pass; Receptor, GPCR P33535 25601 1q11 rat Y166-p 455805 CTMSVDRyIAVCHPV 7tm_1 activity, inhibited 11353794; 19959593 3 0 0 reduces G-protein coupling efficiency of the mu opioid receptor +ATF4 ATF-4 DNA-binding; Transcription factor P18848 468 22q13.1 human T115-p 40420008 MPDDLLTtLDDTCDL protein degradation transcription, inhibited 25795775 1 1 0 +PRDM16 PRDM16 iso4 C2H2-type zinc finger protein; Methyltransferase, protein lysine, predicted Q9HAZ2-4 63976 1p36.32 human K568-sm 25087003 LAHNLLVkAEPKSPR molecular association, regulation cell differentiation, inhibited; carcinogenesis, induced; cell growth, induced; cell differentiation, induced; transcription, altered; transcription, inhibited HDAC2(INDUCES) 21516122; 26559765 2 0 0 +GIT2 GIT2 GAP; GAP, ARF; Motility/polarity/chemotaxis Q14161 9815 12q24.11 human S384-p 30999681 NNQHSVEsQDNDQPD molecular association, regulation; intracellular localization DNA repair, induced MDC1(INDUCES); H2AX(INDUCES); NBS1(INDUCES); PARP1(INDUCES) 25605334 1 3 0 nuclear foci formation +Tfcp2l1 TFCP2L1 DNA-binding Q3UNW5 81879 1|1 E2.3 mouse S397-p 1875342304 QDDSGDNsLCVYHAI protein degradation; molecular association, regulation; ubiquitination; intracellular localization cell differentiation, induced BTRC(INDUCES) 34731635 1 0 0 +Cry1 CRY1 DNA-binding; Lyase; Transcription, coactivator/corepressor P97784 12952 10 C1|10 41.63 cM mouse S280-p 11952907 YKKVKKNsSPPLSLY protein degradation; molecular association, regulation PER2(INDUCES); FBXL3(INDUCES) 19833968 1 0 0 +Smpd3 SMPD3 EC 3.1.4.12; Lipid Metabolism - sphingolipid; Membrane protein, integral; Phospholipase Q9JJY3 58994 8|8 D3 mouse S292-p 4780079 GDSGSLGsPSASRES protein stabilization; enzymatic activity, induced 22074919 1 9 4 +Musk MUSK EC 2.7.10.1; KINASE; Kinase, protein; Membrane protein, integral; Protein kinase, TK; Protein kinase, tyrosine (receptor) Q62838 rat Y754-p 2848302 RNIYSADyYKADGND PK_Tyr_Ser-Thr phosphorylation; enzymatic activity, induced 10619845 1 3 0 promotes MuSK phosphorylation; promotes AChRb clustering and phosphorylation +RACGAP1 MgcRacGAP GAP; GAP, Rac/Rho Q9H0H5 29127 12q13.12 human S164-p 459864 SFDKTDEsLDWDSSL molecular association, regulation; enzymatic activity, induced cell cycle regulation; cytoskeletal reorganization ECT2(INDUCES) 25486482; 35477750 3 5 0 induces Rho GTPase activity; restrain ectopic or premature cytokinesis onset +Fcrl1 FCRL1 Membrane protein, integral Q8R4Y0 229499 3|3 F1 mouse Y297-p 1874990000 NEVYSLVyHTPQVLE phosphorylation 34697226 1 1 0 inhibits ERK phosphorylation +STX1A STX1A Membrane protein, integral; Vesicle Q16623 6804 7q11.23 human S14-p 451261 ELRTAKDsDDDDDVA activity, induced; molecular association, regulation; protein conformation exocytosis, altered; exocytosis, induced DAT(INDUCES); STXBP1(DISRUPTS) 19748891; 25774383; 34948351 7 22 4 +PNPLA2 PNPLA2 EC 3.1.1.3; Lipase; Membrane protein, integral Q96AD5 57104 11p15.5 human K100-ub 21181820 IIRSFLLkVLPADSH Patatin protein degradation 27658392 1 2 0 regulation of hepatic lipid metabolism +Prkci PKCI Cell adhesion; Cell development/differentiation; EC 2.7.11.13; KINASE; Kinase, protein; Motility/polarity/chemotaxis; Oncoprotein; Protein kinase, AGC; Protein kinase, Ser/Thr (non-receptor); Tumor suppressor F1M7Y5 84006 2q24 rat Y265-p 450076 RVIGRGSyAKVLLVR Pkinase intracellular localization KPNB1(INDUCES) 11891849 2 0 0 +Lpp LPP Adaptor/scaffold; Cytoskeletal; Motility/polarity/chemotaxis Q8BFW7 210126 16|16 B1 mouse Y333-p 463381 TWKREAAyAPPASGN cell cycle regulation; cell motility, altered 18515860 0 4 21 +EPS8 EPS8 Adaptor/scaffold Q12929 2059 12p12.3 human Y774-p 457814 CPEGARVySQITVQK SAM_3 cell cycle regulation; cell motility, induced 32641864 2 10 283 +Rreb1 RREB1 C2H2-type zinc finger protein; DNA-binding; Motility/polarity/chemotaxis; Nuclear receptor co-regulator; Transcription, coactivator/corepressor Q3UH06 68750 13|13 A3.3 mouse S161-p 4719122 TTAAAPPsPLKRRRL molecular association, regulation transcription, induced DNA(INDUCES) 31915377 1 35 6 +Ffar4 GPR120 GPCR, family 1; Lipid-binding; Membrane protein, integral; Membrane protein, multi-pass; Receptor, GPCR Q7TMA4 107221 19|19 C2 mouse T347-p 31014807 PEKGAIFtDTSVRRN receptor internalization, induced; molecular association, regulation ARR3(INDUCES) 26873857; 32817367 5 1 0 +Map3k7 TAK1 iso3 EC 2.7.11.25; KINASE; Kinase, protein; Protein kinase, Ser/Thr (non-receptor); Protein kinase, TKL Q923A8 26409 4|4 A5 mouse T187-p 454704 CDIQTHMtNNKGSAA PK_Tyr_Ser-Thr activity, induced; molecular association, regulation apoptosis, induced; signaling pathway regulation TAB2(INDUCES); TRAF6(INDUCES) 30626936 33 1 0 Phosphorylation of JNK, p38 and IkB (subsequent degradation) +Tsc2 TSC2 iso2 Cell cycle regulation; GAP; GAP, misc.; Nuclear receptor co-regulator; Tumor suppressor P49816-2 24855 10q12 rat S1338-p 450215 VDLSFQPsQPLSKSS phosphorylation apoptosis, altered; cell growth, altered 14651849 2 0 1 +Tp53 p53 Activator; DNA-binding; Motility/polarity/chemotaxis; Nuclear receptor co-regulator; Transcription factor; Tumor suppressor P02340 22059 11 B3|11 42.83 cM mouse K317-ac 458976 SASPPQKkKPLDGEY P53_tetramer apoptosis, altered; cell growth, inhibited; apoptosis, induced; transcription, induced; signaling pathway regulation; transcription, altered; translation, altered; apoptosis, inhibited 10990460; 16943427; 18178582; 35534985 56 2 0 HDAC6 ablation induces senescence p21 expression and inhibits cell growth, HDAC6 ablation inhibits HC proliferation after two-thirds partial hepatectomy (PHx); regulates TNF-alpha signaling, p53 K317R mutation affects the response to IR of many proteins; negatively regulates p53 apoptotic activities after DNA damage +STAT5B STAT5B DNA-binding; Oncoprotein; Transcription factor P51692 6777 17q21.2 human S193-p 483615 FGPLAQLsPQERLSR STAT_alpha molecular association, regulation transcription, induced DNA(INDUCES) 22442148 2 18 1 +TRIM14 TRIM14 Transcription regulation Q14142 9830 9q22.33 human K365-ub 27213241 NRQSWCLkRYDLEYW SPRY molecular association, regulation; intracellular localization IKKG(INDUCES) 24379373 1 1 0 assembly of the MAVS signalosome, recruitment of IKKG, IFN activation, and NFkB activation +PTEN PTEN Carbohydrate Metabolism - inositol phosphate; EC 3.1.3.16; EC 3.1.3.48; EC 3.1.3.67; Motility/polarity/chemotaxis; Nuclear receptor co-regulator; PHOSPHATASE; Phosphatase, lipid; Tumor suppressor P60484 5728 10q23.31 human Y27-p 34668100 GFDLDLTyIYPNIIA activity, inhibited 23995781 1 0 0 PTEN downregulation +TH TH Amino Acid Metabolism - tyrosine; EC 1.14.16.2; Endoplasmic reticulum; Mitochondrial; Oxidoreductase; Vesicle P07101 7054 11p15.5 human S62-p 448544 SYTPTPRsPRFIGRR TOH_N enzymatic activity, induced 7901013 43 8 0 +LOC100125989 TPM1 Actin-binding; Motility/polarity/chemotaxis; Motor P58772 rabbit S283-p 451804 HALNDMTsI______ Tropomyosin molecular association, regulation cytoskeletal reorganization TPM1(INDUCES) 10833280 11 15 94 sedimentation and viscometry methods have been used to describe the head-to-tail interaction of TPM1 protein +MAFG MAFG Cell cycle regulation; DNA-binding O15525 4097 17q25.3 human K76-ac 458967 RVKRVTQkEELEKQK bZIP_Maf molecular association, regulation DNA(INDUCES) 11154691 1 0 0 +FEN1 FEN1 DNA repair, damage; DNA-binding; Deoxyribonuclease; EC 3.1.-.-; Nuclear receptor co-regulator; Nucleolus; Ribonuclease P39748 2237 11q12.2 human K377-me 1873037704 TGAAGKFkRGK____ molecular association, regulation DNA repair, induced DNA(DISRUPTS) 28611278 1 1 0 essential for cell survival to replicative stress +SCML2 SCML2 Transcription factor Q9UQR0 10389 Xp22.13 human K123-m1 58123404 QPVGTCEkEGDLLQP MBT molecular association, regulation L3MBTL iso4(INDUCES) 23583077 0 1 0 +Syt12 SYT12 Membrane protein, integral; Vesicle P97610 191595 1q43 rat S97-p 473040 GPPSRKGsLSIEDTF exocytosis, altered 17190793 2 2 0 increases spontaneous neurotransmitter release +Plin1 perilipin 1 Lipid-binding Q8CGN5 103968 7|7 D2 mouse S81-p 450079 EPVVRRLsTQFTAAN Perilipin molecular association, regulation HSL(INDUCES) 19717842 2 8 15 +H4-16 H4 DNA-binding NP_001139343 530773 cow K5-ac 458958 ___SGRGkGGKGLGK methylation cell cycle regulation 18698155 72 22 516 complex relationship of acetylation and methylation of CpG dinucleotides on DNA, during development of gametogenesis and embryogenesis +FUS hnRNP P2 DNA-binding; Nuclear receptor co-regulator; Oncoprotein; RNA splicing; RNA-binding; SUMO LIGASE P35637 2521 16p11.2 human K316-ac 1877549401 GIIKTNKkTGQPMIN RRM_1 molecular association, regulation RNA(DISRUPTS) 32691043 1 1 0 +Ddx46 DDX46 EC 3.6.4.13; Helicase; Spliceosome Q569Z5 212880 13|13 B1 mouse K470-ac 206219705 KECKKFSkTLGLRVV DEAD molecular association, regulation ALKBH5(INDUCES) 28846086 1 0 0 K470R lost its binding to ALKBH5, while other positions did not +kif2c KIF2C Cancer Testis Antigen (CTA); Microtubule-binding; Motility/polarity/chemotaxis; Motor Q91636 380006 frog S110-p 2132101 KEVAAKNsLLSESGA molecular association, regulation; intracellular localization cytoskeletal reorganization DNA(INDUCES) 17567953 1 0 0 +Crebbp CBP ACETYLTRANSFERASE; Acetyltransferase; DNA-binding; EC 2.3.1.48; Motility/polarity/chemotaxis; Nuclear receptor co-regulator; Transcription, coactivator/corepressor P45481 12914 16 A1|16 2.4 cM mouse R600-me 478320 EHVTQDLrSHLVHKL KIX molecular association, regulation CREB(DISRUPTS) 11701890 2 0 0 +XRCC5 Ku80 DNA-binding; EC 3.6.1.-; EC 3.6.4.-; Helicase; Nuclear receptor co-regulator; Nucleolus; RNA-binding P13010 7520 2q35 human K144-ub 10844844 DLSSRFSkSQLDIII Ku_N molecular association, regulation DNA repair, induced DNA(DISRUPTS) 27895153 1 6 24 +BCL2L11 BIM Apoptosis O43521 10018 2q13 human S98-p 8080218 RSSSGYFsFDTDRSP protein degradation; molecular association, regulation; ubiquitination BTRC(INDUCES) 23912711 1 0 0 +UVRAG UVRAG Autophagy Q9P2Y5 7405 11q13.5 human S498-p 1222327 GFSGGIPsPDKGHRK protein stabilization; molecular association, regulation carcinogenesis, induced; cell growth, induced; autophagy, inhibited rubicon(INDUCES) 25533187 2 38 26 interaction with RUBICON supressed Vsp34 kinase activity, endosome-lysosomal degradation of EGFR induced +Hck Hck EC 2.7.10.2; KINASE; Kinase, protein; Oncoprotein; Protein kinase, TK; Protein kinase, tyrosine (non-receptor) P08103 15162 2 H1|2 75.41 cM mouse Y409-p 448168 RIIEDNEyTAREGAK PK_Tyr_Ser-Thr phosphorylation; enzymatic activity, induced 10934191; 27531930 13 70 2093 phosphorylation of PKCD +ZNF282 ZNF282 C2H2-type zinc finger protein Q9UDV7 8427 7q36.1 human K293-sm 31094513 QDASSQVkREDTLCV molecular association, regulation carcinogenesis, induced; transcription, induced CALCOCO1(INDUCES); ER-alpha(INDUCES) 22986521 1 0 0 +HIF1A HIF1A Autophagy; DNA-binding; Transcription factor Q16665 3091 14q23.2 human S696-p 17595900 NVLSVALsQRTTVPE protein stabilization transcription, altered 21095582 2 1 0 required for the hypoxic regulation of the mTOR pathway +Nsfl1c NSFL1C Vesicle Q9CZ44 386649 2|2 G3 mouse S176-p 468328 AGERRRHsGQDVHVV activity, induced cell growth, induced 30783609 1 37 9 Induce/promote dendritic cell growth and dentritic arborization +MTF1 MTF1 C2H2-type zinc finger protein; Transcription factor Q14872 4520 1p34.3 human S152-p 50784002 EGCPRTYsTAGNLRT zf-C2H2 activity, inhibited apoptosis, induced; transcription, inhibited 35027733 1 3 0 +RHO Rhodopsin GPCR, family 1; Membrane protein, integral; Membrane protein, multi-pass; Receptor, GPCR P02699 509933 cow S334-p 448677 PLGDDEAsTTVSKTE molecular association, regulation; protein conformation SAG(INDUCES) 15041682 8 6 0 Computational and in vitro data. S343 may be a weaker interaction. +SOS1 SOS1 Adaptor/scaffold; GEF; GEF, Ras; Motility/polarity/chemotaxis Q07889 6654 2p22.1 human S1134-p 483244 PHGPRSAsVSSISLT molecular association, regulation signaling pathway regulation 14-3-3 epsilon(INDUCES) 22827337 1 31 3 +CDC25A CDC25A EC 3.1.3.48; Motility/polarity/chemotaxis; PHOSPHATASE; Protein phosphatase, dual-specificity P30304 993 3p21.31 human S116-p 449977 PQKLLGCsPALKRSH M-inducer_phosp protein stabilization cell cycle regulation CDK1(INDUCES) 12411508 2 7 0 +PTH PTH Apoptosis; Hormone; Secreted; Secreted, signal peptide P01270 5741 11p15.3 human S48-p 25750949 NLGKHLNsMERVEWL Parathyroid molecular association, regulation signaling pathway regulation PTHR(INDUCES) 25158085 1 1 1 +App APP Apoptosis; Cell surface; Membrane protein, integral; Receptor, misc.; Transcription factor P12023 11820 16 C3.3|16 46.92 cM mouse S679-p 480465 DAEFGHDsGFEVRHQ Beta-APP molecular association, regulation; protein conformation 21527912; 27400251 9 2 0 increases the number of binding proteins; aggregation by promotion of beta-sheet conformation, increased toxicity, degeneration of eyes induced and AB accumulation in Drosophila +CEBPA C/EBP-alpha DNA-binding; Transcription factor P49715 1050 19q13.11 human R165-m1 1878324502 LVIKQEPrEEDEAKQ cell cycle regulation; carcinogenesis, induced; cell growth, induced; transcription, inhibited HDAC3(DISRUPTS) 31015230 1 1 0 +PACS2 PACS2 Q86VP3 23241 14q32.33 human S213-p 1884003504 FSSEQEAsDDAVQGQ intracellular localization 37523531 1 0 0 +ZFP36L1 BRF1 Transcription factor Q07352 677 14q24.1 human S54-p 2475300 GGFPRRHsVTLPSSK Tis11B_N activity, induced; protein stabilization; molecular association, regulation cell growth, inhibited; transcription, altered 14-3-3 beta(INDUCES) 18326031; 26280535; 27708140 3 37 13 inhibits BRF1-dependent AMD ( ARE-mediated mRNA decay); senescence-associated secretory phenotype (SASP) +SNAI1 Snail1 C2H2-type zinc finger protein; Transcription factor O95863 6615 20q13.13 human S246-p 455616 QACARTFsRMSLLHK intracellular localization carcinogenesis, induced; transcription, inhibited; transcription, altered 15833848; 25125660; 28423359 3 0 0 nuclear accumulation +MYL12A MRLC3 Contractile P19105 10627 18p11.31 human S19-p 7382102 KRPQRATsNVFAMFD molecular association, regulation; protein conformation; enzymatic activity, induced cell cycle regulation; exocytosis, induced; cytoskeletal reorganization MRLC3(DISRUPTS) 10944522; 12446732; 15069078; 15753305; 8530442; 9651368; 9786863 16 60 246 +HIF1A HIF1A Autophagy; DNA-binding; Transcription factor Q16665 3091 14q23.2 human S551-p 34494910 TEAKNPFsTQDTDLD HIF-1 protein degradation cell growth, inhibited; cell motility, inhibited; signaling pathway regulation 30254159 1 0 0 PI3K pathway and AKT are strongly activated by IRIS +SET SET Apoptosis; DNA replication; DNA-binding; Inhibitor; Nuclear receptor co-regulator; Oncoprotein; Protein phosphatase, regulatory subunit Q01105 6418 9q34.11 human K150-ub 3935287 ENPYFENkVLSKEFH NAP protein degradation 35843886 1 8 35 +GAB1 GAB1 Adaptor/scaffold; Motility/polarity/chemotaxis Q13480 2549 4q31.21 human Y659-p 447949 VADERVDyVVVDQQK molecular association, regulation cell cycle regulation; carcinogenesis, induced; cell motility, induced SHP-2(INDUCES) 11323411; 34731623 9 49 1482 +KRAS KRas iso2 G protein; G protein, monomeric; G protein, monomeric, Ras; Motility/polarity/chemotaxis; Oncoprotein P01116-2 3845 12p12.1 human K104-ub 31914116 REQIKRVkDSEDVPM Ras protein conformation 33929846 2 0 0 preferred configurations/conformations while sampling a large conformational space, K104 has a minimal effect on RBD or CRD recognition. ubiquitination at K104, but not K147, potentially affects both membrane reorientation and dimerization of KRAS +TCF3 E2A Cell development/differentiation; DNA-binding; Oncoprotein; Transcription factor P15923 6929 19p13.3 human S139-p 455905 LNSPGPLsPSGMKGT transcription, induced; cell growth, altered 11114297; 31540485 3 9 0 POSTN expression +RTKN RTKN iso2 G protein regulator, misc. Q9BST9-2 6242 2p13.1 human S435-p 15423057 QALAKQGsLYHEMAI enzymatic activity, induced cytoskeletal reorganization 22228765 1 5 1 RhoA activity induced; enhances actin stress fibre formation +PTPRJ PTPRJ EC 3.1.3.48; Membrane protein, integral; Motility/polarity/chemotaxis; PHOSPHATASE; Receptor protein phosphatase, tyrosine Q12913 5795 11p11.2 human Y1311-p 473909 DSKVDLIyQNTTAMT molecular association, regulation; enzymatic activity, induced cell motility, induced Src(INDUCES) 22898603 1 2 13 +CLIP1 Restin Cytoskeletal P30622 6249 12q24.31 human T287-p 483203 KIGFPSTtPAKAKAN molecular association, regulation; intracellular localization cell cycle regulation PLK1(INDUCES) 24777477 3 6 3 PLK1 recruitment to kinetochores, kinetochore localization of CENP-E, kinetochore-fiber stability, chromosome alignment +TP63 p63 DNA-binding; Transcription factor Q9H3D4 8626 3q28 human Y149-p 452168 SVTAPSPyAQPSSTF protein stabilization transcription, altered 19783996 1 0 0 +PSTPIP2 PSTPIP2 Actin-binding Q9H939 9050 18q21.1|tdb7990 human Y323-p 449698 SSPDDPNySLVDDYS molecular association, regulation SHIP(INDUCES) 26304991 1 3 4 +MAPRE1 EB1 Cytoskeletal; Motility/polarity/chemotaxis Q15691 22919 20q11.21 human S156-p 1259758900 PKKPLTSsSAAPQRP intracellular localization carcinogenesis, inhibited; cytoskeletal reorganization; cell motility, inhibited; signaling pathway regulation 30250248 1 0 0 enhances cytotoxicity +AANAT AA-NAT ACETYLTRANSFERASE; Acetyltransferase; Amino Acid Metabolism - tryptophan; EC 2.3.1.87 Q29495 443531 sheep S205-p 452142 HAALRRNsDR_____ protein stabilization; molecular association, regulation; enzymatic activity, inhibited 14-3-3 beta(INDUCES); 14-3-3 zeta(INDUCES) 15632116; 15644438; 18771288 3 0 1 +BSG BSG iso2 Immunoglobulin superfamily; Membrane protein, integral P35613-2 682 19p13.3 human Y183-p 38486780 MEADPGQyRCNGTSS Ig_3 molecular association, regulation carcinogenesis, induced; cell motility, induced MGAT5(INDUCES) 32291412 1 2 0 induce MMP-9 expression +TYK2 Tyk2 EC 2.7.10.2; KINASE; Kinase, protein; Protein kinase, TK; Protein kinase, tyrosine (non-receptor) P29597 7297 19p13.2 human Y1054-p 447499 AVPEGHEyYRVREDG PK_Tyr_Ser-Thr enzymatic activity, induced signaling pathway regulation 31341059; 8702790 9 2 59 +PPARG PPAR-gamma DNA-binding; Nuclear receptor; Transcription factor P37231 5468 3p25.2 human K184-ub 40190201 DLNCRIHkKSRNKCQ zf-C4 protein degradation; intracellular localization cell differentiation, inhibited 24336050 1 0 0 +GRIN2B NMDAR2B Channel, calcium; Channel, ligand-gated; Membrane protein, integral; Membrane protein, multi-pass Q13224 2904 12p13.1 human S1323-p 455808 ALAPRSVsLKDKGRF NMDAR2_C activity, induced 22179603 5 2 1 Phosphorylation increased receptor mechanosensitivity-neuronal stretch sensitivity +GABBR1 GABBR1 GPCR, family 3; Membrane protein, integral; Membrane protein, multi-pass; Receptor, GPCR Q9UBS5 2550 6p22.1 human K900-ub 54191601 KENRELEkIIAEKEE protein degradation; ubiquitination 26817839 1 0 0 +AMOTL2 AMOTL2 Cell adhesion Q9Y2J4 51421 3q22.2 human S159-p 29674704 HGHVRSLsERLLQLS phosphorylation 24225952 1 4 0 YAP phosphorylation +Lrrk1 LRRK1 EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, Ser/Thr (non-receptor); Protein kinase, TKL Q3UHC2 233328 7|7 C mouse Y1430-p 460480 GVEGTPGyQAPEIRP Pkinase enzymatic activity, induced 20697350 0 1 8 +CDC5L CDC5L DNA-binding; Motility/polarity/chemotaxis; RNA processing; RNA splicing; Spliceosome; Transcription factor Q99459 988 6p21.1 human T411-p 469436 TPNTVLStPFRTPSN Myb_Cef RNA splicing, altered 18583928 1 4 32 +Kcnj1 ROMK iso2 Channel, potassium; Membrane protein, integral; Membrane protein, multi-pass P35560-2 rat S200-p 2461201 RVANLRKsLLIGSHI IRK_C activity, induced 8621594 5 0 0 phosphorylation of at least two serines necessary for channel activity +Slc12a5 KCC2 iso2 Membrane protein, integral; Membrane protein, multi-pass; Transporter; Transporter, SLC family Q91V14-2 57138 2|2 H3 mouse T906-p 10045603 SAYTYEKtLVMEQRS SLC12 activity, inhibited neural plasticity 27025876; 31396048 7 4 0 regulates hyperpolarizing synaptic inhibition and adulthood cognitive function +CACB CACNA1C Channel, calcium; Membrane protein, integral; Membrane protein, multi-pass P15381 100101555 rabbit S1575-p 467228 VACKRLVsMNMPLNS GPHH activity, induced 16820363 4 0 0 +Ccnb1 CCNB1 Activator; Cell cycle regulation P24860 268697 13 D1|13 53.23 cM mouse S123-p 448814 PILVDNPsPSPMETS cytoskeletal reorganization 25349079 11 2 0 promotes meiotic resumption +SIK2 QIK EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, CAMK; Protein kinase, Ser/Thr (non-receptor) Q9H0K1 23235 11q23.1 human K53-ac 27581523 VAIKIIDkSQLDAVN Pkinase intracellular localization; enzymatic activity, inhibited; phosphorylation autophagy, induced 23322770 1 1 0 inhibits autophosphorylation of QIK, promotes aggresome removal +Tmod1 TMOD1 Cell development/differentiation; Contractile; Cytoskeletal; Motility/polarity/chemotaxis P49813 21916 4 B1|4 24.49 cM mouse T54-p 22561900 GLRQKDQtTKAPTGP Tropomodulin cytoskeletal reorganization 24891520 2 0 0 pointed-end assembly and thin filament length regulatory function +GHR GH receptor Membrane protein, integral; Receptor, cytokine NP_999419 397488 pig Y566-p 486257 SFNQEDIyITTESLT GHBP transcription, induced DNA(INDUCES) 8647880 3 0 0 +PHLPP1 PHLPP EC 3.1.3.16; PHOSPHATASE; Protein phosphatase, Ser/Thr (non-receptor); Tumor suppressor O60346 23239 18q21.33 human T409-p 1871700800 QPLPLPQtASSPQPQ cell cycle regulation 33397691 1 1 0 +GRB2 GRB2 Adaptor/scaffold; Cell development/differentiation; Motility/polarity/chemotaxis P62993 2885 17q25.1 human Y52-p 7388002 DGFIPKNyIEMKPHP cell growth, altered 19273609 1 0 1 regulates cell proliferation +Nphs1 NPHS1 Cell adhesion; Immunoglobulin superfamily; Membrane protein, integral Q9R044 64563 1q21 rat Y1152-p 6377604 TAEVDPNyYSMRDFS molecular association, regulation; phosphorylation SHP-1(INDUCES) 25404734 3 0 0 +PPM1B PPM1B EC 3.1.3.16; Motility/polarity/chemotaxis; PHOSPHATASE; Protein phosphatase, Ser/Thr (non-receptor) O75688 5495 2p21 human K326-ub 21182132 RVEEIMEkSGEEGMP PP2C_C ubiquitination; intracellular localization 35176871 1 3 0 Yap inhibits ubiquitination and nuclear translocation ; nuclear translocation +Ptk2 FAK iso2 EC 2.7.10.2; KINASE; Kinase, protein; Protein kinase, TK; Protein kinase, tyrosine (non-receptor) P34152-2 14083 15 D3|15 33.94 cM mouse Y892-p 447965 PTGNQHIyQPVGKPD cell motility, induced; cell growth, induced 21900245 75 21 307 attachment independent FAK phosphorylation requires paxillin +Camk2b CAMK2B EC 2.7.11.17; KINASE; Kinase, protein; Protein kinase, CAMK; Protein kinase, Ser/Thr (non-receptor) P08413 24245 14q21 rat S363-p 3558927 TNSTKNSsAITSPKG molecular association, regulation 26291163 1 6 0 inhibits interaction with F-actin, regulates synaptic plasticity +Ptk2 FAK iso4 EC 2.7.10.2; KINASE; Kinase, protein; Protein kinase, TK; Protein kinase, tyrosine (non-receptor) P34152-4 14083 15 D3|15 33.94 cM mouse Y397-p 447887 SVSETDDyAEIIDEE apoptosis, induced; cytoskeletal reorganization; signaling pathway regulation 30187999 371 31 474 a6?4/FAK/p38 pathway regulation; increased desmin expression; podocyte injury; decreased WT1, synaptopodin expression +Cdh5 CDH5 Cell adhesion; Membrane protein, integral; Motility/polarity/chemotaxis P55284 12562 8 D3|8 53.04 cM mouse Y733-p 2028402 DTLHIYGyEGAESIA CADH_Y-type_LIR cell motility, altered 18096689 1 0 1 affects cell migration and increased endothelial cell barrier permeability +SIRPA SHPS1 Cell adhesion; Cell surface; Membrane protein, integral; Motility/polarity/chemotaxis; Receptor, misc. P78324 140885 20p13 human Y429-p 458557 QDTNDITyADLNLPK molecular association, regulation; phosphorylation cell motility, induced; cell growth, induced; signaling pathway regulation SHP-2(INDUCES); SHP-1(INDUCES) 10842184; 18233962; 21799000 3 12 49 regulation TLR3/4-dependent cytokine production pathway; induces phosphorylation of MAPK, regulates SHPS-1 signaling; Mutation of these 4 tyrosines does not affect JAK2 binding. However, overexpression of the WT SHPS1 but not the 4 tyrosine to phenylalanine mutation reduces tyrosine phosphorylation of Jak2, STAT5B, and STAT3 and activation of Erk1/2 in response to growth hormone. Does not affect STAT3 tyrosine phosphorylation in response to LIF agonist. +LIMD1 LIMD1 Motility/polarity/chemotaxis; Tumor suppressor Q9UGP4 8994 3p21.31 human S421-p 3214989 LGSVLLDsPSSPRVR cell cycle regulation; carcinogenesis, inhibited; cell growth, inhibited; cell motility, inhibited 30600590 1 21 0 mitotic phosphorylation required for mitotic progression +Gsc GSC DNA-binding; Transcription factor Q02591 14836 12 E|12 54.32 cM mouse K209-sm 2887202 EKVEVWFkNRRAKWR Homeodomain transcription, inhibited 18336814 1 0 0 SUMO modification inhibition is promoter specific +Npy1r NPY1R GPCR, family 1; Membrane protein, integral; Membrane protein, multi-pass; Receptor, GPCR P21555 29358 16p14 rat S375-p 2815305 PVAFKKIsMNDNEKI receptor internalization, altered 15576634 1 2 0 may be an artifact of the truncation mutants +EPHA3 EphA3 EC 2.7.10.1; KINASE; Kinase, protein; Membrane protein, integral; Protein kinase, TK; Protein kinase, tyrosine (receptor) P29320 2042 3p11.1 human Y742-p 25290781 KYLSDMGyVHRDLAA PK_Tyr_Ser-Thr protein conformation; enzymatic activity, induced 18547520 1 1 1 +CELF1 CELF1 Cell development/differentiation; RNA processing; RNA-binding Q92879 10658 11p11.2 human T173-p 29668007 KAMHQAQtMEGCSSP RRM_1 RNA splicing, altered 24151077 1 2 0 splicing regulation in diabetes +Nfatc2 NFAT1 DNA-binding; Transcription factor Q60591 18019 2 H3|2 88.91 cM mouse S278-p 447851 PQRSRSPsPQPSPHV transcription, inhibited 11030334 0 1 0 +SIAH2 SIAH2 EC 6.3.2.-; EC 6.3.2.19; Ligase; Transcription, coactivator/corepressor; UBIQUITIN LIGASE; Ubiquitin conjugating system; Ubiquitin ligase O43255 6478 3q25.1 human S6-p 25172963 __MSRPSsTGPSANK protein stabilization carcinogenesis, induced; cell motility, induced; cell growth, induced 33536006 1 2 0 +DPYSL3 CRMP-4 Hydrolase Q14195 1809 5q32 human T514-p 458798 TTTPKGGtPAGSARG carcinogenesis, induced 30154149 1 27 16 +PPARG PPAR-gamma DNA-binding; Nuclear receptor; Transcription factor P37231 5468 3p25.2 human K185-ub 40190200 LNCRIHKkSRNKCQY zf-C4 protein degradation; intracellular localization cell differentiation, inhibited 24336050 1 0 0 +ATP2A2 SERCA2 Cell adhesion; EC 3.6.3.8; Endoplasmic reticulum; Hydrolase; Membrane protein, integral; Membrane protein, multi-pass; Transporter; Transporter, ion channel P16615 488 12q24.11 human S663-p 452253 EFDELNPsAQRDACL enzymatic activity, inhibited cell growth, inhibited 37291092 1 69 3 ,regulates Ca2+ homeostasis +TGFBR2 TGFBR2 EC 2.7.11.30; KINASE; Kinase, protein; Membrane protein, integral; Oncoprotein; Protein kinase, Ser/Thr (receptor); Protein kinase, TKL P37173 7048 3p24.1 human Y284-p 479864 KIFPYEEyASWKTEK PK_Tyr_Ser-Thr molecular association, regulation cytoskeletal reorganization; cell growth, altered GRB2(INDUCES); SHC1(INDUCES) 17440088; 18174260 3 0 0 important for TGF beta -induced cell invasion; stimulates cell invasion; important for TGF-beta-mediated activation of p38MAPK +Itgb1 ITGB1 Cell adhesion; Cell surface; Membrane protein, integral; Motility/polarity/chemotaxis; Receptor, misc. P09055 16412 8|8 E2 mouse Y783-p 447710 DTGENPIyKSAVTTV Integrin_b_cyt cell motility, altered; cell adhesion, altered 10891511; 11259684 7 42 1183 +SUZ12 SUZ12 C2H2-type zinc finger protein; Oncoprotein; Transcription factor Q15022 23512 17q11.2 human S539-p 4746706 RPKRTKAsMSEFLES molecular association, regulation; ubiquitination EZH2(DISRUPTS) 25855382 1 4 0 +ATF2 ATF-2 ACETYLTRANSFERASE; C2H2-type zinc finger protein; EC 2.3.1.48; Transcription factor P15336 1386 2q31.1 human S498-p 455783 QIVMAPSsQSQPSGS intracellular localization 15916964 1 0 0 S472/480 are important for ionizing radiation-induced S phase checkpoint control +BECN1 beclin 1 Adaptor/scaffold; Autophagy; Membrane protein, peripheral Q14457 8678 17q21.31 human S337-p 41389909 LVPYGNHsYLESLTD APG6 autophagy, induced 26118643 1 1 0 +Slc22a1 SLC22A1 Membrane protein, integral; Membrane protein, multi-pass; Transporter; Transporter, SLC family Q63089 24904 1q11 rat T550-p 455614 TIYLQVQtGKSSST_ activity, induced 15829703 1 0 0 stimulates ASP+ uptake +DDX5 DDX5 EC 3.6.4.13; Helicase; Nuclear receptor co-regulator; Nucleolus; RNA splicing; RNA-binding; Spliceosome P17844 1655 17q23.3 human K40-ac 11321885 KFGNPGEkLVKKKWN protein stabilization; molecular association, regulation carcinogenesis, induced; transcription, induced HDAC1(INDUCES); HDAC2(INDUCES) 20663877 1 6 9 +DOC2B DOC2B Lipid-binding Q14184 8447 17p13.3 human S34-p 1267669105 IRPIKQIsDYFPRFP intracellular localization 30369065 1 0 0 translocated to the plasma membrane, enhanced glucose uptake +Runx2 AML3 iso5 DNA-binding; Transcription factor Q08775-5 12393 17 B3|17 21.33 cM mouse K225-ub 1873375612 ATYHRAIkVTVDGPR Runt cell differentiation, induced; transcription, induced 28500134 1 0 0 +Atp5po ATP5O EC 3.6.3.14; Energy Metabolism - oxidative phosphorylation; Hydrolase; Mitochondrial Q9DB20 28080 16|16 C4 mouse K162-ac 461458 SELKTVLkSFLSPNQ OSCP enzymatic activity, inhibited 24252090 2 9 66 +G6PD G6PD Carbohydrate Metabolism - pentose phosphate pathway; Cell development/differentiation; EC 1.1.1.49; Other Amino Acids Metabolism - glutathione; Oxidoreductase P11413 2539 Xq28 human Y249-p 462295 GTEGRGGyFDEFGII G6PD_C enzymatic activity, induced carcinogenesis, inhibited; cell growth, inhibited 37491277 1 4 9 +Cap1 CAP1 Actin-binding; Cytoskeletal P40124 12331 4|4 D2.2 mouse S36-p 15719534 CGYGDSPsKGAVPYV CAP_N molecular association, regulation cytoskeletal reorganization; cell motility, inhibited Cofilin-1(INDUCES) 25315833 1 7 6 +SCN1A SCN1A Channel, sodium; Membrane protein, integral; Membrane protein, multi-pass P35498 6323 2q24.3 human T1909-p 1239966002 SYQPITTtLKRKQEE molecular association, regulation Calmodulin(INDUCES) 30142967 1 0 0 +Gab2 GAB2 Adaptor/scaffold Q9Z1S8 14389 7|7 E1 mouse S614-p 12097630 DFQPGSPsPHRKPST molecular association, regulation PIK3R1(DISRUPTS) 28096188 1 0 6 +HIF1A HIF1A Autophagy; DNA-binding; Transcription factor Q16665 3091 14q23.2 human T796-p 451302 ESGLPQLtSYDCEVN HIF-1a_CTAD transcription, induced 11983697 1 0 0 +ARL4A ARL4A G protein, monomeric; G protein, monomeric, ARF; Nucleolus P40617 10124 7p21.3 human S143-p 1877718400 QDLRNSLsLSEIEKL Arf protein stabilization; molecular association, regulation; ubiquitination; intracellular localization cell motility, induced HYPK(INDUCES) 35857868 1 1 0 inhibits ubiquitination +SIRT1 SIRT1 Apoptosis; DEACETYLASE; Deacetylase; EC 3.5.1.-; Nuclear receptor co-regulator Q96EB6 23411 10q21.3 human S732-p 1874020214 EAINEAIsVKQEVTD molecular association, regulation; acetylation; protein conformation; enzymatic activity, induced transcription, induced p53(INDUCES); DBC1(DISRUPTS) 34216621 1 1 0 inhibits PGC-1a deacetylation +TP53 p53 Activator; DNA-binding; Motility/polarity/chemotaxis; Nuclear receptor co-regulator; Transcription factor; Tumor suppressor P04637 7157 17p13.1 human S392-p 447535 FKTEGPDsD______ activity, induced; protein degradation; protein stabilization; molecular association, regulation; ubiquitination; intracellular localization; protein conformation cell cycle regulation; carcinogenesis, induced; apoptosis, altered; carcinogenesis, inhibited; cell growth, inhibited; apoptosis, induced; transcription, induced; transcription, altered; transcription, inhibited S100B(DISRUPTS); UBE4B(INDUCES); S100A2(DISRUPTS); p21Cip1(INDUCES); SMAD3(INDUCES); MDM2(DISRUPTS); MDC1(INDUCES); CDK1(DISRUPTS); NFkB-p65(INDUCES) DNA(INDUCES) 10656682; 11239457; 15155458; 15471885; 16651424; 17108107; 17237827; 17891183; 18523266; 18778462; 19819244; 20024960; 21317932; 21423215; 21832239; 22975381; 24194938; 25767119; 26673821; 28937686; 32093423; 32181328; 34103685; 34209868; 34216619; 34282274; 34711610; 34798143; 34980600; 36243702; 9254608; 9315650; 9467949 118 15 0 +ETS1 Ets-1 DNA-binding; Motility/polarity/chemotaxis; Oncoprotein; Transcription factor P14921 2113 11q24.3 human S282-p 449317 NSLQRVPsYDSFDSE Ets1_N_flank protein stabilization; molecular association, regulation; activity, inhibited transcription, inhibited COP1(INDUCES) DNA(DISRUPTS) 12475968; 25024220; 25117710 7 10 87 induces autoinhibition +Grin2b NMDAR2B Channel, calcium; Channel, ligand-gated; Membrane protein, integral; Membrane protein, multi-pass Q00960 24410 4q43 rat S1303-p 450171 NKLRRQHsYDTFVDL NMDAR2_C molecular association, regulation; intracellular localization; phosphorylation signaling pathway regulation CAMK2A(DISRUPTS) 10764765; 29422059; 32415270 48 14 31 pathway regulating Rd-induced protection from extrasynaptic NMDAR-triggered neuronal injury; reduced membrane expression CaMKII, reduced phosphorylation of GluR1 +MUC1 MUC1 Actin-binding; Cell adhesion; Membrane protein, integral; Motility/polarity/chemotaxis; Nuclear receptor co-regulator; Tumor suppressor P15941 4582 1q22 human Y1218-p 473759 TYHTHGRyVPPSSTD intracellular localization cell motility, altered 17545600 1 5 56 nuclear localization; Phosphorylation enhanced invasion in vitro, through Matrigel. +ULK1 ULK1 Autophagy; EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, Other; Protein kinase, Ser/Thr (non-receptor) O75385 8408 12q24.33 human K68-ac 1881147401 GKEIKILkELKHENI autophagy, inhibited 33431796 1 1 0 may reduce pyroptosis +KMT5A SETD8 Amino Acid Metabolism - lysine degradation; EC 2.1.1.43; METHYLTRANSFERASE; Methyltransferase; Methyltransferase, protein lysine Q9NQR1 387893 12q24.31 human S100-p 3213381 SKIYSYMsPNKCSGM protein stabilization; ubiquitination; intracellular localization cell cycle regulation 20966048 1 6 0 phosphorylation of this site results in the removal of SETD8 from mitotic chromosomes; inhibits SETD8 ubiquitination +Stat1 STAT1 DNA-binding; Transcription factor Q9QXK0 25124 9q22 rat K703-sm 3278913 PKRTGYIkTELISVS molecular association, regulation DNA(DISRUPTS) 21102409 9 3 0 increased sumoylation (decreased phosphorylation) improved spatial learning +MAPT Tau iso3 ACETYLTRANSFERASE; Acetyltransferase; Cytoskeletal P10636-3 4137 17q21.31 human S199-p 449328 KVTSKCGsLGNIHHK Tubulin-binding autophagy, inhibited 33967735 12 8 2 +NOS2 iNOS Amino Acid Metabolism - arginine and proline; EC 1.14.13.39; Oxidoreductase P35228 4843 17q11.2 human Y151-p 457593 IEFVNQYyGSFKEAK NO_synthase intracellular localization; enzymatic activity, inhibited 16116474 3 0 0 +BEST1 BEST1 Channel, chloride; Membrane protein, integral; Membrane protein, multi-pass; Transporter; Transporter, ion channel O76090 7439 11q12.3 human Y227-p 28706303 QCGHLYAyDWISIPL Bestrophin intracellular localization 23880862 1 0 0 Basolateral localization and delivery +Exoc8 EXOC8 Vesicle O54924 245709 19q12 rat S366-p 182950104 EDKPSPPsVKELRAK Exo84_C molecular association, regulation exocytosis, inhibited Sec5(DISRUPTS); EXOC8(DISRUPTS) 28325821 1 1 0 +FOXO1 FOXO1A DNA-binding; Nuclear receptor co-regulator; Oncoprotein; Transcription factor Q12778 2308 13q14.11 human S256-p 448075 SPRRRAAsMDNNSKF protein degradation; molecular association, regulation; intracellular localization; activity, inhibited; phosphorylation carcinogenesis, inhibited; cell growth, induced; transcription, altered; transcription, inhibited 14-3-3 beta(INDUCES); SKP2(INDUCES); PCAF(INDUCES) DNA(DISRUPTS) 10358076; 11237865; 12228231; 14664696; 15668399; 15934941; 16076959; 16670091; 20041807; 20061393; 20357092; 20519497; 21980390; 22081023; 23995784; 35679032; 36756789 98 8 48 +TRPM6 ChaK2 Channel, cation; EC 2.7.11.1; KINASE; Kinase, protein; Membrane protein, integral; Membrane protein, multi-pass; Protein kinase, Ser/Thr (non-receptor); Protein kinase, atypical Q9BX84 140803 9q21.13 human T1851-p 2255402 FNQVKPQtIPYTPRF Alpha_kinase activity, inhibited 18258429 2 2 0 RACK1-induced inhibition of channel activity is dependent on T1851 phosphorylation +NPFFR2 NPFFR2 GPCR, family 1; Membrane protein, integral; Membrane protein, multi-pass; Receptor, GPCR Q9Y5X5 10886 4q13.3 human T517-p 36533412 MEELKETtNSSEI__ receptor desensitization, induced 25326382 1 1 0 +PRKG1 PKG1 EC 2.7.11.12; KINASE; Kinase, protein; Protein kinase, AGC; Protein kinase, Ser/Thr (non-receptor) Q13976 5592 10q11.23-q21.1 human T517-p 452153 GFGKKTWtFCGTPEY Pkinase phosphorylation; enzymatic activity, induced transcription, altered 10644746 3 4 13 promotes phosphorylation of p38 and ATF2-dependent transcription +DYRK2 DYRK2 iso2 EC 2.7.12.1; KINASE; Kinase, protein; Protein kinase, CMGC; Protein kinase, dual-specificity (non-receptor) Q92630-2 8445 12q15 human S501-p 1874397824 PPPSSSAsKLRTNLA enzymatic activity, induced cell cycle regulation; apoptosis, induced 34363019 1 1 0 +TERF1 TRF1 DNA-binding P54274 7013 8q21.11 human T273-p 6417401 SKRTRTItSQDKPSG protein stabilization; molecular association, regulation; phosphorylation carcinogenesis, induced; chromatin organization, altered; cell growth, induced; transcription, inhibited DNA(INDUCES) 33690611 2 0 0 binds telomeric DNA, inhibits CHK phosphorylation +PARP1 PARP1 DNA repair, damage; EC 2.4.2.30; Nuclear envelope; Nuclear receptor co-regulator; Nucleolus; Transferase P09874 142 1q42.12 human K249-ub 12396812 NDLIWNIkDELKKVC protein degradation; ubiquitination 34555594 1 4 1 vascular injury and remodeling by increasing PARP1-K249 acetylation and PARP1 levels in mice +MBD1 MBD1 Transcription factor Q9UIS9 4152 18q21.1 human K538-sm 3144813 DPGLPSVkQEPPDPE molecular association, regulation transcription, induced SETDB1(DISRUPTS) 17066076 1 3 0 +ROCK2 ROCK2 EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, AGC; Protein kinase, Ser/Thr (non-receptor) O75116 9475 2p25.1 human Y722-p 464192 LADKNKIyESIEEAK molecular association, regulation; enzymatic activity, inhibited cell motility, altered; cell adhesion, altered; signaling pathway regulation RHOA(DISRUPTS) 18559669; 31722979 5 7 127 +HAUS8 HAUS8 Cell cycle regulation Q9BT25 93323 19p13.11 human S133-p 20609208 KPESTSFsAPRKKSP intracellular localization cell cycle regulation; apoptosis, inhibited 21690413 1 2 0 localization to the spindle +TUBA1B TUBA1B Cytoskeletal; Motility/polarity/chemotaxis P68363 10376 12q13.12 human K394-me 476774 AWARLDHkFDLMYAK molecular association, regulation Other(DISRUPTS) 8097117 1 0 0 inhibits microtubule assembly +Map3k2 MEKK2 EC 2.7.11.25; KINASE; Kinase, protein; Protein kinase, STE; Protein kinase, Ser/Thr (non-receptor) F1M9D0 171492 18p12 rat S164-p 1984188 PPNRDRSsPPPGYIP apoptosis, induced 28039298 1 24 10 +ITGB1 ITGB1 Cell adhesion; Cell surface; Membrane protein, integral; Motility/polarity/chemotaxis; Receptor, misc. P05556 3688 10p11.22 human T789-p 447709 IYKSAVTtVVNPKYE Integrin_b_cyt activity, induced; molecular association, regulation; protein conformation cell adhesion, induced; cell motility, altered; cell adhesion, altered FLNA(DISRUPTS); kindlin-2(DISRUPTS); talin 1(DISRUPTS) 14660602; 15949469; 19115199; 33119040 14 3 1 +RUNX3 AML2 DNA-binding; Transcription factor Q13761 864 1p36.11 human K129-m2 1877292604 RNASAVMkNQVARFN Runt molecular association, regulation cell cycle regulation; carcinogenesis, induced; cell growth, induced; transcription, inhibited CBFB(DISRUPTS); p300(DISRUPTS) 33116296 1 1 0 +MST1R Ron EC 2.7.10.1; KINASE; Kinase, protein; Membrane protein, integral; Protein kinase, TK; Protein kinase, tyrosine (receptor) Q04912 4486 3p21.31 human Y1238-p 454933 RDILDREyYSVQQHR PK_Tyr_Ser-Thr protein conformation; phosphorylation; enzymatic activity, induced cell cycle regulation; carcinogenesis, inhibited; cell growth, inhibited 20726546; 24739671; 35569509 8 7 183 +Eif2ak4 GCN2 EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, Other; Protein kinase, Ser/Thr (non-receptor); Translation Q9QZ05 27103 2|2 E5 mouse T898-p 455461 SDPSGHLtGMVGTAL Pkinase transcription, induced 36273589 5 0 0 +RANBP2 RANBP2 Adaptor/scaffold; EC 5.2.1.8; EC 6.3.2.-; Ligase; Nuclear export; Nucleoporin; SUMO LIGASE; SUMO conjugating system; SUMO ligase P49792 5903 2q13 human S2246-p 468567 SSSSVHAsPLASSPV molecular association, regulation; intracellular localization BICD2(INDUCES) 26051540 1 29 0 targets BicD2 to the NE of RGP cells to induce apical nuclear migration +ETS1 Ets-1 DNA-binding; Motility/polarity/chemotaxis; Oncoprotein; Transcription factor P13474 396235 chicken S257-p 449319 DSFESIEsYDSCDRL Ets1_N_flank activity, inhibited 7961750 4 0 1 The in vitro interaction of Ets-1 with a high-affinity Ets binding site was assayed with EMSA. +YAP1 YAP1 iso2 Oncoprotein; Transcription, coactivator/corepressor P46937-2 10413 11q22.1 human S109-p 452305 KSHSRQAsTDAGTAG activity, inhibited cell differentiation, induced; cell growth, inhibited; transcription, inhibited 23027127; 23752589 23 63 341 +Tfeb TFEB DNA-binding; Transcription factor Q9R210 21425 17 C|17 23.99 cM mouse S210-p 25529700 MVGVTSSsCPADLTQ intracellular localization transcription, inhibited 36097072 22 3 0 +XRCC5 Ku80 DNA-binding; EC 3.6.1.-; EC 3.6.4.-; Helicase; Nuclear receptor co-regulator; Nucleolus; RNA-binding P13010 7520 2q35 human K285-ub 62489909 VVDAKTLkKEDIQKE Ku molecular association, regulation DNA repair, induced DNA(DISRUPTS) 27895153 1 0 0 +Slc29a1 SLC29A1 Membrane protein, integral; Membrane protein, multi-pass; Transporter; Transporter, SLC family Q9JIM1 63959 17|17 B3 mouse S254-p 486282 ETKLDLIsKGEEPKG Nucleoside_tran activity, induced; molecular association, regulation cell growth, induced SLC29A1(DISRUPTS) 17520485 2 10 0 +Gja1 GJA1 Channel, misc.; Membrane protein, integral; Membrane protein, multi-pass; Motility/polarity/chemotaxis P08050 24392 20q11 rat S279-p 448853 SSPTAPLsPMSPPGY molecular association, regulation; intracellular localization; activity, inhibited; phosphorylation endocytosis, induced GJA1(INDUCES) 23363606; 23922949; 26841867; 30981509; 9535909 42 6 1 Phosphorylation of S279 impairs Cx43 assembly into gap junctions. +PPP1CC PPP1CC EC 3.1.3.16; Motility/polarity/chemotaxis; Nucleolus; PHOSPHATASE; Protein phosphatase, Ser/Thr (non-receptor) P36873 5501 12q24.11 human T311-p 3913895 PNATRPVtPPRGMIT enzymatic activity, inhibited 20948546 1 9 30 +GNA15 G-alpha 15 G protein; G protein, heterotrimeric; G protein, heterotrimeric alpha G(q) P30679 2769 19p13.3 human S336-p 11380905 GSKKGARsRRLFSHY G-alpha activity, induced 12647293 1 0 0 GNA15 receptor mediated PLC-B activation +EIF4EBP1 4E-BP1 Translation; Translation initiation Q13541 1978 8p11.23 human S112-p 447526 KRAGGEEsQFEMDI_ eIF_4EBP molecular association, regulation; phosphorylation EIF4E(DISRUPTS) 12588975 5 15 28 Deletion of (QFEMDI) sequence affected phosphorlation of multiple phosphorylation sites. ; S111 did not affect binding to EIF4E. +NUP98 NUP98 iso2 Motility/polarity/chemotaxis; Nucleoporin P52948-2 4928 11p15.4 human S606-p 452729 RDSENLAsPSEYPEN intracellular localization 21335236 1 71 6 as multiple sites (13PM) mutant +CD44 CD44 iso12 Cell adhesion; Membrane protein, integral; Motility/polarity/chemotaxis; Receptor, misc. P16070-12 960 11p13 human S291-p 455524 AVCIAVNsRRRCGQK molecular association, regulation; protein conformation Moesin(DISRUPTS) 25925953; 26217011 5 0 0 regulates dimer formation and ectodomain cleavage; inhibits clevage, TPA induced CD44 cleavage requires dephosphorylation of S291 +FBP1 FBPase Carbohydrate Metabolism - fructose and mannose; Carbohydrate Metabolism - glycolysis and gluconeogenesis; Carbohydrate Metabolism - pentose phosphate pathway; EC 3.1.3.11; Mitochondrial; Phosphatase (non-protein) P09467 2203 9q22.32 human S144-p 15501075 FGIYRKKsTDEPSEK FBPase molecular association, regulation carcinogenesis, induced; cell motility, induced; cell growth, induced; transcription, induced; signaling pathway regulation CHIP(DISRUPTS); NFkB-p65(DISRUPTS) 32754266 1 4 3 induces NFKB binding to DNA, regulates NFKB pathway +TJP2 ZO2 Adaptor/scaffold; Motility/polarity/chemotaxis Q9UDY2 9414 9q21.11 human K730-sm 1883981501 LLREAGFkRPVVLFG protein stabilization; molecular association, regulation occludin(INDUCES); ZO1(INDUCES) 36291162 1 0 0 stability of hZO-2 is regulated by K48 polyubiquitin and K759, K997 ubiquitylation and K730 SUMOylation, mutations in ZO2 ubiquitylation and ylation sites disrupt the interaction with occludin and ZO1as well as tight junction (TJ) barrier function +Cttn Cortactin Actin-binding; Cytoskeletal; Motility/polarity/chemotaxis Q60598 13043 7|7 F5 mouse Y482-p 447704 YQAEDDTyDGYESDL molecular association, regulation cell motility, induced; cytoskeletal reorganization CBLL1(INDUCES); MTUS2(DISRUPTS); VAV2(INDUCES); FAK(DISRUPTS); smMLCK(INDUCES) 12408982; 17343955; 22078467; 22252131; 22952866; 27451391; 34439396 25 1 3 Tyr to Phe mutation of this site prevents FAK-mediated FA turnover +Pld2 PLD2 EC 3.1.4.4; Lipid Metabolism - ether lipid; Lipid Metabolism - glycerophospholipid; Motility/polarity/chemotaxis; Phospholipase P97813 18806 11 B3|11 42.99 cM mouse Y470-p 453412 GRWDDVQyRLTDLGD intracellular localization 15282299 1 0 0 Y14 F and YallF showed altered location in cytoplasm rather than at the plasmamembrane. +Cysltr1 CYSLTR1 GPCR, family 1; Membrane protein, integral; Membrane protein, multi-pass; Receptor, GPCR Q99JA4 58861 X|X D mouse T323-p 11143513 NFRRRLStFRKHSLS receptor desensitization, induced 23485744 1 0 2 +ARHGAP17 ARHGAP17 GAP; GAP, Rac/Rho Q68EM7 55114 16p12.1 human S702-p 472376 LSAPRRYsSSLSPIQ molecular association, regulation; intracellular localization TRIP10(DISRUPTS); FNBP1L(INDUCES) 26507661; 36571786 2 13 34 regulates invadopodia disassembly +Ccnt1 CCNT1 Cell cycle regulation; Transcription initiation complex Q9QWV9 12455 15|15 F1 mouse K386-ac 25174700 SKSVPSAkVSLKEYR molecular association, regulation; enzymatic activity, induced transcription, induced BCDIN3(DISRUPTS); HEXIM1(DISRUPTS) 19387490 3 1 0 enhances CDK9/cyclin T1 transcriptional activity, disrupting HEXIM1 and BCDIN3 association +G6PD G6PD Carbohydrate Metabolism - pentose phosphate pathway; Cell development/differentiation; EC 1.1.1.49; Other Amino Acids Metabolism - glutathione; Oxidoreductase P11413 2539 Xq28 human T145-p 1883583400 FYLALPPtVYEAVTK molecular association, regulation; enzymatic activity, induced cell growth, induced Other(INDUCES) 37478541 1 0 0 induces binding to NADP +DPYSL2 CRMP-2 Microtubule-binding; Motility/polarity/chemotaxis Q16555 1808 8p21.2 human T514-p 454386 SVTPKTVtPASSAKT molecular association, regulation; intracellular localization carcinogenesis, inhibited; apoptosis, induced; cell motility, inhibited; cytoskeletal reorganization DRP1(DISRUPTS); RHOT2(DISRUPTS); RECK(DISRUPTS); Tau iso8(INDUCES); MFN2(DISRUPTS) 28500272; 32019603; 32778769; 34831395; 34975828; 37174687 33 36 35 +Gja1 GJA1 Channel, misc.; Membrane protein, integral; Membrane protein, multi-pass; Motility/polarity/chemotaxis P08050 24392 20q11 rat S330-p 449994 AGSTISNsHAQPFDF Connexin43 intracellular localization cell adhesion, induced; cell adhesion, altered; signaling pathway regulation 12270943; 23742896 10 14 0 cardiomyocyte FGF signaling, maintenance of cell-cell gap junctions +Insr INSR EC 2.7.10.1; KINASE; Kinase, protein; Membrane protein, integral; Protein kinase, TK; Protein kinase, tyrosine (receptor) P15208 16337 8 A1.1|8 1.82 cM mouse Y1175-p 447680 FGMTRDIyETDYYRK PK_Tyr_Ser-Thr cell cycle regulation; cell motility, altered 18515860 38 31 455 +Htt Huntingtin Cytoskeletal P42859 15194 5 B2|5 17.92 cM mouse S16-p 12056100 KAFESLKsFQQQQQQ protein degradation; molecular association, regulation; intracellular localization TPR(DISRUPTS) 21245084 18 2 0 +TP53 p53 Activator; DNA-binding; Motility/polarity/chemotaxis; Nuclear receptor co-regulator; Transcription factor; Tumor suppressor P04637 7157 17p13.1 human K370-ub 464661 RAHSSHLkSKKGQST protein degradation; molecular association, regulation; intracellular localization transcription, inhibited ING1(DISRUPTS) 11046142; 17371868; 19927155; 21731648 9 1 0 K370/372/373/381/382/386/R mutant shows 613-fold activation of p53; binds unmodified or six multimonoubiquitinated forms of wild-type p53 +Krt18 K18 Cytoskeletal; Nucleolus P05784 16668 15 F2|15 57.22 cM mouse S35-p 447733 RPASSAAsVYAGAGG intracellular localization cytoskeletal reorganization 10623656 14 27 13 +INTS11 INTS11 EC 3.1.27.-; RNA processing; Ribonuclease Q5TA45 54973 1p36.33 human K381-sm 1883375205 GRQVLEVkMQVEYMS RMMBL molecular association, regulation; intracellular localization 36454007 1 0 0 regulates Integrator subcellular localization and interaction with integrator subunits +Myo5a MYO5A Motility/polarity/chemotaxis; Motor Q99104 17918 9 D|9 42.26 cM mouse S1650-p 480053 GLRKRTSsIADEGTY molecular association, regulation ACTN1(INDUCES) 17515613 2 21 10 +HNRNPUL1 E1B-AP5 RNA splicing; RNA-binding Q9BUJ2 11100 19q13.2 human R656-m1 12198334 SGGGGNYrGGFNRSG molecular association, regulation; intracellular localization NBS1(INDUCES) 26020839 1 4 25 ecruitment at sites of damage +ACE2 ACE2 EC 3.4.17.23; Membrane protein, integral; Protease Q9BYF1 59272 Xp22.2 human S783-p 23078777 SGENPYAsIDISKGE protein stabilization; molecular association, regulation AP2M1(INDUCES); GABARAP(INDUCES); LC3A(INDUCES) 33436498; 35894122 2 1 2 SARS-CoV-2 infection induces GLK overexpression and subsequent ACE2 stabilization +ENG ENG Membrane protein, integral; Motility/polarity/chemotaxis; Receptor, misc. P17813 2022 9q34.11 human S646-p 12064201 STNHSIGsTQSTPCS cell motility, altered 20042635 1 0 0 regulates TGF-beta signaling via ALK1/Smad1/5/8 pathway +Rasgrp2 RASGRP2 GEF; GEF, Ras Q9QUG9 19395 19|19 A mouse S586-p 10993875 PRPGRRSsRPPEIRE activity, induced; molecular association, regulation 14-3-3 beta(INDUCES) 26804993 3 9 36 +NR4A1 Nur77 Apoptosis; DNA-binding; Nuclear receptor P22736 3164 12q13.13 human S52-p 41583604 AAPTALPsFSTFMDG cell motility, induced; cell growth, induced; cytoskeletal reorganization 26155943 1 0 0 required for increase in cell growth, cell motility, monolayer permeability, and formation of actin stress fibers. +CD28 CD28 Cell surface; Membrane protein, integral P10747 940 2q33.2 human Y218-p 450285 PPRDFAAyRS_____ activity, induced; phosphorylation carcinogenesis, inhibited; cell growth, inhibited; transcription, induced; signaling pathway regulation; transcription, altered NFkB-p65(INDUCES) 12842899; 20368329; 30131370 4 4 180 +CORO1A coronin 1A Cytoskeletal; Motility/polarity/chemotaxis P31146 11151 16p11.2 human T412-p 3995219 RVNRGLDtGRRRAAP Trimer_CC molecular association, regulation; intracellular localization endocytosis, induced ACTB(DISRUPTS) 23100250; 34189278 2 2 4 +FOXP3 FOXP3 C2H2-type zinc finger protein; Cell cycle regulation; DNA-binding; Transcription factor Q9BZS1 50943 Xp11.23 human S418-p 27623902 LEFRKKRsQRPSRCS Forkhead phosphorylation cell growth, inhibited; transcription, induced DNA(INDUCES) 23396208; 25096571; 30011797 4 0 0 UBC9 transcription induced +PDGFRB PDGFRB EC 2.7.10.1; KINASE; Kinase, protein; Membrane protein, integral; Oncoprotein; Protein kinase, TK; Protein kinase, tyrosine (receptor) P09619 5159 5q32 human S254-p 1876167502 WTYPRKEsGRLVEPV Ig_3 enzymatic activity, inhibited; phosphorylation carcinogenesis, inhibited; cell growth, inhibited; cell motility, inhibited; signaling pathway regulation 35066967 1 0 0 inhibits phosphorylation of itself on other sites, further inhibiting PI3K/Akt and MAPK/ERK pathways +NFE2L2 NRF2 DNA-binding; Transcription factor Q16236 4780 2q31.2 human K599-ac 23940021 FLVPKSKkPDVKKN_ molecular association, regulation; intracellular localization transcription, induced DNA(INDUCES) 21196497 1 0 0 +TIRAP TIRAP Adaptor/scaffold P58753 114609 11q24.2 human Y86-p 463808 SSRWSKDyDVCVCHS activity, induced; molecular association, regulation; phosphorylation transcription, induced; signaling pathway regulation TLR4(DISRUPTS); MYD88(DISRUPTS); Btk(INDUCES); P38A(INDUCES) 16439361; 18070880; 24840642; 35379857 4 0 0 TLR2/TLR4 signaling +NCL NCL DNA-binding; Helicase; Nuclear receptor co-regulator; Nucleolus; RNA-binding P19338 4691 2q37.1 human S153-p 449270 DEEEDDDsEEDEEDD intracellular localization cell cycle regulation; cell growth, induced 25313645 1 38 59 +CBL CBL Adaptor/scaffold; EC 6.3.2.-; EC 6.3.2.19; Ligase; Motility/polarity/chemotaxis; Oncoprotein; UBIQUITIN LIGASE; Ubiquitin conjugating system; Ubiquitin ligase P22681 867 11q23.3 human Y774-p 448531 SENEDDGyDVPKPPV protein degradation; molecular association, regulation; enzymatic activity, induced; phosphorylation cell growth, induced; cell motility, induced; cell adhesion, induced; cell motility, altered; signaling pathway regulation; cell growth, altered Src(INDUCES); VEGFR2(INDUCES); CRKL(INDUCES); CBL(INDUCES); CRK(INDUCES); PIK3CA(INDUCES) 11997497; 12604776; 15922744; 17372230; 21967979; 26848865; 33512474; 9988765 16 4 257 The double mutant Y700/774F was used in this study; CD93 binds to Cbl inducing phosphorylation on tyrosine 774 of CBL; induces cytokine signaling; integrin-mediated platelet outside-in signaling leading to platelet spreading; Src induces Cbl phosphorylation inducing Cbl degredation and alters EGFR desensitization. +ETV1 ETV1 DNA-binding; Oncoprotein; Transcription factor P50549 2115 7p21.2 human K33-ac 458950 PTNVRKRkFINRDLA ETS_PEA3_N protein stabilization; molecular association, regulation transcription, induced DNA(INDUCES) 12917345 1 0 0 +Nr3c1 GR DNA-binding; Mitochondrial; Nuclear receptor; Transcription factor P06537 14815 18 B3|18 21.09 cM mouse S229-p 447968 PGKETNEsPWRSDLL GCR transcription, induced; transcription, inhibited; signaling pathway regulation 21994940; 30738183 51 5 0 +TNFRSF10A TRAIL-R1 Membrane protein, integral O00220 8797 8p21.3 human S424-gl 1873593500 NKTGRNAsIHTLLDA Death apoptosis, induced 30987996 1 0 0 TRAIL-mediated cell death apoptosis and necrosis, TRAIL resistance +CSNK1E CK1E EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, CK1; Protein kinase, Ser/Thr (non-receptor) P49674 1454 22q13.1 human S405-p 449794 EVSRIPAsQTSVPFD enzymatic activity, inhibited 10542239; 12223474 2 18 4 some subset of these 8 sites +PSIP1 LEDGF Motility/polarity/chemotaxis; Transcription, coactivator/corepressor O75475 11168 9p22.3 human K364-sm 13875714 AEIKNSLkIDNLDVN LEDGF protein degradation; molecular association, regulation cell growth, inhibited; transcription, inhibited DNA(DISRUPTS) 20382164; 22748127 2 0 0 +SCAP SCAP Membrane protein, integral; Membrane protein, multi-pass Q12770 22937 3p21.31 human K305-ub 1877340000 YIYFSTRkIDMVKSK activity, induced; protein conformation transcription, induced 32054686 1 0 0 promotes loop 1?loop 7 interaction, cholesterol biosynthesis +RUNX3 AML2 DNA-binding; Transcription factor Q13761 864 1p36.11 human T209-p 25526800 ERLRMRVtPSTPSPR protein degradation; molecular association, regulation; ubiquitination; intracellular localization; activity, inhibited carcinogenesis, induced; cell growth, induced; transcription, altered HSP90A(INDUCES); HSC70(INDUCES); ANXA2(INDUCES); PIN1(INDUCES); hnRNP A1(INDUCES) 22580604; 26898755; 34253860 3 3 0 +PRC1 PRC1 Cell cycle regulation; Cytoskeletal; Microtubule-binding; Motility/polarity/chemotaxis O43663 9055 15q26.1 human T481-p 483541 RRGLAPNtPGKARKL activity, induced; intracellular localization; activity, inhibited; phosphorylation cell cycle regulation; carcinogenesis, inhibited; cell growth, induced; chromatin organization, altered; cytoskeletal reorganization 16603632; 17512944; 24120663; 27551054; 30626720; 30992425; 34158398 11 21 12 +TP53 p53 Activator; DNA-binding; Motility/polarity/chemotaxis; Nuclear receptor co-regulator; Transcription factor; Tumor suppressor P04637 7157 17p13.1 human R335-m2 5009202 FTLQIRGrERFEMFR P53_tetramer cell cycle regulation; apoptosis, inhibited; transcription, altered 53BP1(INDUCES) 19011621 1 1 0 PRMT5 enhanced p53-dependent cell-cycle arrest; after treatment with PRMT5 theere was a reduction in dimer and tetramer formation; arginine methylation affects the promoter specificity of p53 +Sik1 SIK EC 2.7.11.1; KINASE; Kinase, protein; Motility/polarity/chemotaxis; Protein kinase, CAMK; Protein kinase, Ser/Thr (non-receptor); Tumor suppressor Q60670 17691 17 B1|17 17.25 cM mouse T475-p 15570318 GSTGRRHtLAEVSTH protein stabilization; intracellular localization 23256157 1 4 1 +FCRL4 FCRL4 Membrane protein, integral Q96PJ5 83417 1q23.1 human Y493-p 22730003 DKDVSVVySEVKTQH molecular association, regulation signaling pathway regulation Ig-alpha(INDUCES) 21908428; 25972488 2 0 0 all 3 sites (Y451, Y463, Y493) inhibits BCR signaling and enhances TLR9 signaling +Tbc1d1 TBC1D1 DEUBIQUITINASE; GAP; GAP, Rab; Ubiquitin-specific protease Q60949 57915 5 C3.1|5 32.8 cM mouse T590-p 1247778 AFRRRANtLSHFPVE activity, inhibited; phosphorylation 18215134; 19740738 11 13 137 reduces inhibitory effect on TBC1D1 on GLUT4 translocation; p70S6K phosphorylation +Ephb2 EphB2 EC 2.7.10.1; KINASE; Kinase, protein; Membrane protein, integral; Protein kinase, TK; Protein kinase, tyrosine (receptor); Tumor suppressor P54763 13844 4 D3|4 69.0 cM mouse Y504-p 139835700 GLKAGAIyVFQVRAR fn3 molecular association, regulation; intracellular localization NMDAR1(INDUCES) 28719605 1 1 0 cell surface,retain NMDARs to spine synapse, pathological pain, mechanical hypersensitivity +LMNA lamin A/C Cytoskeletal P02545 4000 1q22 human T10-p 1244434 TPSQRRAtRSGAQAS molecular association, regulation lamin A/C(DISRUPTS) 35839855 1 4 44 +Scn2a SCN2A Channel, sodium; Membrane protein, integral; Membrane protein, multi-pass P04775 24766 3q21 rat S576-p 2999206 PRRNSRAsLFNFKGR Na_trans_cytopl activity, induced 12359152 1 3 1 +Ric8a RIC8A GEF; GEF, misc. Q3TIR3 101489 7|7 F4 mouse S501-p 3213318 VIQPMGMsPRGHLTS Ric8 intracellular localization cytoskeletal reorganization 24092753 2 37 2 dorsal ruffle turnover, phosphorylated S501 localization in the cytoplasm +FOXO1 FOXO1A DNA-binding; Nuclear receptor co-regulator; Oncoprotein; Transcription factor Q12778 2308 13q14.11 human K248-ac 459031 PEGGKSGkSPRRRAA Forkhead molecular association, regulation; intracellular localization; activity, inhibited; phosphorylation carcinogenesis, inhibited; apoptosis, induced; transcription, inhibited DNA(DISRUPTS) 15220471; 16076959; 18786403; 20519497; 27132507 9 1 0 +EFHD2 EFHD2 Calcium-binding Q96C19 79180 1p36.21 human S183-p 28761200 RLSEIDVsSEGVKGA protein conformation cytoskeletal reorganization 23959172; 28011271 2 1 0 cofilin-induced actin depolymerization, modulates cofilin distribution to the leading edges of lamellipodia induced by EGF, regulation of lamellipodia dynamics; re-orientation of actin-binding sites, reduction in actin-bundling activity +Prkcd PKCD EC 2.7.11.13; KINASE; Kinase, protein; Nuclear receptor co-regulator; Protein kinase, AGC; Protein kinase, Ser/Thr (non-receptor); Protein kinase, tyrosine (non-receptor); Tumor suppressor P09215 170538 16p16 rat Y523-p 450231 EILQGLKySFSVDWW Pkinase enzymatic activity, induced 9326592 4 0 0 +Stim1 STIM1 Calcium-binding; Endoplasmic reticulum; Membrane protein, integral P70302 20866 7 E2-E3|7 54.71 cM mouse S621-p 3635048 SHSLSPSsPDPDTPS molecular association, regulation; protein conformation ORAI1(INDUCES); EB1(INDUCES) 20736304; 23687376 8 11 1 calcium mobilization and EB1-dependent STIM1 multimerization ; regulate store operated calcium entry (SOCE) +IKBKG IKKG Adaptor/scaffold; Protein kinase, regulatory subunit Q9Y6K9 8517 Xq28 human K325-ub 7482001 AREKLAEkKELLQEQ CC2-LZ signaling pathway regulation 17728323 2 0 1 +Th TH Amino Acid Metabolism - tyrosine; EC 1.14.16.2; Endoplasmic reticulum; Mitochondrial; Oxidoreductase; Vesicle P04177 25085 1q41 rat S8-p 448543 MPTPSAPsPQPKGFR TOH_N protein stabilization 15639226 5 1 0 Phosphorylation of S8 S19 and S31 (more stable) may stabilize TH already phosphorylated at S40 (least stable). +NPHS1 NPHS1 Cell adhesion; Immunoglobulin superfamily; Membrane protein, integral O60500 4868 19q13.12 human Y1176-p 2299202 MAFPGHLyDEVERTY intracellular localization endocytosis, induced; exocytosis, induced; cell adhesion, induced; cytoskeletal reorganization 22718751; 36822326 8 0 0 +SLFN11 SLFN11 Q7Z7L1 91607 17q12 human S219-p 1869008603 LVEFKQFsTKHFQEY AlbA_2 activity, inhibited translation, induced 31395656 1 1 0 p24 expression and activity depend on S753 site +GLS glutaminase Amino Acid Metabolism - alanine, aspartate and glutamate; Amino Acid Metabolism - arginine and proline; EC 3.5.1.2; Energy Metabolism - nitrogen; Hydrolase; Mitochondrial; Other Amino Acids Metabolism - D-Glutamine and D-glutamate O94925 2744 2q32.2 human K158-ub 22244990 QEKIPVHkFITALKS EF-hand_14 protein degradation; ubiquitination; succinylation carcinogenesis, inhibited; cell growth, inhibited 31843902 1 2 0 SIRT5 downregulated +GRIN1 NMDAR1 Channel, calcium; Channel, ligand-gated; Membrane protein, integral; Membrane protein, multi-pass Q05586 2902 9q34.3 human Y837-p 17613300 LIFIEIAyKRHKDAR CaM_bdg_C0 molecular association, regulation CSK(INDUCES) 21113815 1 0 0 Y837F mutation prevents the CSK-induced down-regulation of NMDAR1 activity +PKD1 PKD1 Cell adhesion; Membrane protein, integral; Membrane protein, multi-pass P98161 5310 16p13.3 human S4252-p 466929 SLQGRRSsRAPAGSS cell differentiation, altered 17980165 2 0 0 +Cbx5 HP1 alpha Transcription, coactivator/corepressor Q61686 12419 15|15 F3 mouse S14-p 476165 RTADSSSsEDEEEYV molecular association, regulation H3(INDUCES) DNA(INDUCES) 21245376 1 42 3 important for chromosomal stability +IRF3 IRF3 DNA-binding; Transcription factor Q14653 3661 19q13.33 human S402-p 449030 ISNSHPLsLTSDQYK activity, induced; protein degradation; molecular association, regulation; intracellular localization autophagy, induced; transcription, induced; transcription, altered CALCOCO2(INDUCES) 18272581; 19153595; 25070846; 27992402; 37330913; 9566918 9 3 0 GPR108 and Smurf1 mediated degradation requires NDP52; NDP52-dependent autophagic degradation of phosphorylated IRF3; GPR108 interacts with Smurf1, followed by the recruitment of IRF3 during viral infection +PREB PREB GEF, misc.; Membrane protein, integral; Transcription factor Q9HCU5 10113 2p23.3 human Y10-p 1868624703 RRRAPELyRAPFPLY activity, inhibited signaling pathway regulation 31227593 1 0 0 regulates endoplasmic reticulum (ER) signaling +Mafb MAFB DNA-binding; Oncoprotein; Transcription factor; Tumor suppressor P54841 16658 2 H2|2 80.92 cM mouse T62-p 11555107 VSSTPLStPCSSVPS protein degradation 19932079 1 0 0 +ABL1 Abl EC 2.7.10.2; KINASE; Kinase, protein; Oncoprotein; Protein kinase, TK; Protein kinase, tyrosine (non-receptor) P00519 25 9q34.12 human Y70-p 462900 PNLFVALyDFVASGD SH3_1 activity, induced; molecular association, regulation; enzymatic activity, induced Abi-1(DISRUPTS) 16912036; 18775435 2 0 12 +GRHL1 GRHL1 Transcription factor Q9NZI5 29841 2p25.1 human S76-p 3252757 KVPRERRsSTAKPEV intracellular localization cell cycle regulation; carcinogenesis, induced; cell growth, induced; transcription, induced 33931584 1 1 4 +LRRC45 LRRC45 Q96CN5 201255 17q25.3 human S661-p 28850300 VLAYVQAsPVRTLSP molecular association, regulation; protein processing; intracellular localization cell cycle regulation CEP250(INDUCES); CROCC(INDUCES) 24035387 1 4 0 phosphorylation of LRRC45 affects the assembly of its filament structure, centrosome localization- leading to centrosome separation +Ripk1 RIPK1 EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, Ser/Thr (non-receptor); Protein kinase, TKL Q60855 19766 13 A3.3|13 14.01 cM mouse K612-ub 2188102 ERDGLKEkVYQMLQK Death ubiquitination; enzymatic activity, induced apoptosis, induced FADD(INDUCES); CASP8(INDUCES) 33311474 4 4 0 Ripk1 K612R/K612R mice develop adult-onset intestinal in?ammation and splenomegaly, antibiotics rescues spontaneous gut in?ammation of RIPK1 K612R mutant mice; RDA (RIPK1 kinase dependent apoptosis) and necroptosis in response to TNFR1 signaling, p-IKKa/?, p-ERK1/2, p-JNK, and p-P38 were decreased in TNFa stimulated Ripk1K612R/K612R MEFs ; K627 localized in DD is a key ubiquitination site that can regulate the overall ubiquitination pattern of RIPK; cells stimulated by T/S and T/5Z-7; K627 in hRIPK1 is important for RIPK1 homodimerization +TP53 p53 Activator; DNA-binding; Motility/polarity/chemotaxis; Nuclear receptor co-regulator; Transcription factor; Tumor suppressor P04637 7157 17p13.1 human Y220-p 34824801 RHSVVVPyEPPEVGS P53 protein degradation; molecular association, regulation; activity, inhibited carcinogenesis, induced; DNA repair, inhibited HERC5(INDUCES) 25071020 1 0 0 promotes ISGylation +CHD4 CHD-4 DNA-binding; EC 3.6.4.12; Helicase Q14839 1108 12p13.31 human S308-p 471447 FGSKRKRsSSEDDDL molecular association, regulation chromatin organization, altered; transcription, induced DNA(DISRUPTS); RNA(DISRUPTS) 29907651 1 11 4 +BLM BLM DNA repair, damage; DNA replication; EC 3.6.4.12; Helicase P54132 641 15q26.1 human K317-sm 2293704 SASSSSSkCLSTLKD BLM_N intracellular localization; phosphorylation chromatin organization, altered 15829507; 31171703 3 0 0 localization to PML bodies determined by the ratio of SUMO and SIM in telomere clustering scaffolds; inhibits phosphorylation of H2AX +GATA2 GATA2 Transcription factor P23769 2624 3q21.3 human S192-p 14573920 PSTTGAAsPASSSAG molecular association, regulation; intracellular localization; phosphorylation carcinogenesis, induced; transcription, induced DNA(INDUCES) 25056917; 27545880 2 6 0 chromatin occupancy, nuclear foci localization; S192-dependent GATA-2 hyperphosphorylation +PAGE4 PAGE4 Cancer Testis Antigen (CTA) O60829 9506 Xp11.23 human T85-p 15421970 GSDVKEKtPPNPKHA GAGE protein conformation 28289210 1 2 0 +MIS18A MIS18A Cell cycle regulation Q9NYP9 54069 21q22.11 human S36-p 18012204 SLLGKRLsEDSSRHQ cell cycle regulation 29416714 1 9 1 necessary for faithful mitotic division; enhances PLK1 kinetochore recruitment +KIF14 KIF14 Microtubule-binding; Motor Q15058 9928 1q32.1 human S1219-p 114810407 KNLHSSHsSGLMDKS intracellular localization 28630147 1 0 0 spindle localization of Kif14 in anaphase +Rorc RORC DNA-binding; Nuclear receptor; Transcription factor P51450 19885 3|3 F2.1 mouse S203-p 4708350 ASCHLEYsPERGKAE transcription, altered 35294872 1 3 0 +Ptpn11 SHP-2 EC 3.1.3.48; Motility/polarity/chemotaxis; PHOSPHATASE; Protein phosphatase, tyrosine (non-receptor) P35235 19247 5|5 F mouse Y542-p 448492 SKRKGHEyTNIKYSL molecular association, regulation; intracellular localization; enzymatic activity, induced transcription, induced; cell adhesion, altered; signaling pathway regulation GRB2(INDUCES); SHPS1(INDUCES); Vinculin(INDUCES); Calnexin(INDUCES); GRP78(INDUCES); IP3R1(INDUCES) 11779868; 12923167; 16905534; 33574084; 34582250; 35034964 38 25 442 +H2AX H2AX DNA repair, damage; DNA-binding; Helicase P16104 3014 11q23.3 human Y142-p 3397700 ATQASQEy_______ molecular association, regulation cell cycle regulation; carcinogenesis, inhibited; cell growth, inhibited; apoptosis, induced; cell motility, inhibited; signaling pathway regulation; DNA repair, altered; transcription, inhibited Fe65(INDUCES); JNK1(INDUCES) 19234442; 20703100; 31151422; 34711990 10 2 2 +Cd300lf IREM-1 Immunoglobulin superfamily; Membrane protein, integral; Receptor, misc. Q6SJQ7 246746 11|11 E2 mouse Y276-p 474548 DHQEEVEyVTMAPFP SIT activity, induced; molecular association, regulation; intracellular localization endocytosis, induced; cytoskeletal reorganization; signaling pathway regulation PIK3R1(INDUCES) 24477292 3 0 0 1. phagocytosis of apoptotic cells 2. Activation of Rac/Cdc42 3. PI3K-Rac/Cdc42 pathway +ESR1 ER-alpha DNA-binding; Nuclear receptor; Transcription factor P03372 2099 6q25.1-q25.2 human S559-p 6048400 PTSRGGAsVEETDQS ESR1_C activity, inhibited transcription, altered 20043841 4 1 0 inhibits ligand-independent activation of ER-alpha +Tbc1d4 AS160 GAP; GAP, Rab Q8BYJ6 210789 14|14 E2.3 mouse S324-p 455925 EFRSRCSsVTGVMQK PID molecular association, regulation; phosphorylation 14-3-3 gamma(INDUCES) 19923418; 33872597 13 18 334 +MALT1 MALT1 Adaptor/scaffold; Apoptosis; EC 3.4.22.-; Ligase; Nuclear export; Protease; UBIQUITIN LIGASE; Ubiquitin conjugating system Q9UDY8 10892 18q21.32 human K677-ub 2134701 TRLSSLQkLKEHLVF MALT1_Ig protein degradation; molecular association, regulation IKKA(INDUCES) 17948050 1 1 0 activation of NF-kB pathway and IL-2 induction +SKA3 SKA3 Cell cycle regulation Q8IX90 221150 13q12.11 human T291-p 459961 PLVPTFCtPGLKIPS molecular association, regulation; intracellular localization cell cycle regulation; chromatin organization, altered; cytoskeletal reorganization HEC1(INDUCES) 32491969 1 4 0 +Grik2 GluR6 Channel, calcium; Channel, ligand-gated; Membrane protein, integral; Membrane protein, multi-pass P39087 14806 10 B3|10 24.87 cM mouse S846-p 11496000 VGEFLYKsKKNAQLE intracellular localization endocytosis, altered 19920140 5 0 0 +RAP1GAP RAP1GAP GAP; GAP, Ras; Motility/polarity/chemotaxis P47736 5909 1p36.12 human S441-p 1210678 VIRSRSQsMDAMGLS activity, induced 19218462 1 19 72 increased Rap1 activity +Gata3 GATA3 Transcription factor P23772 14462 2 A1|2 6.69 cM mouse S308-p 456464 IKPKRRLsAARRAGT cell growth, induced DNA(INDUCES) 23851685 4 0 0 binds to Il-5, IL-13 promoters, production of IL-5 and IL-13 +Lhcgr LHR GPCR, family 1; Membrane protein, integral; Membrane protein, multi-pass; Receptor, GPCR P16235 25477 6q12 rat S661-p 451062 LYRRKEFsAYTSNCK receptor internalization, altered 9660797 1 0 0 S661 is required for agonist-induced uncoupling and internalization. +TCF7L2 TCF7L2 Apoptosis; Cell cycle regulation; Cell development/differentiation; DNA-binding; Motility/polarity/chemotaxis; Transcription factor Q9NQB0 6934 10q25.2-q25.3 human K173-ac 31077502 LQSRQALkDARSPSP CTNNB1_binding protein conformation transcription, induced 23613959 1 1 0 decreases susceptibility to HBP1 mediated repression, has a strong influence on the structure of TCF7L2-DNA complex +MAPK7 ERK5 EC 2.7.11.24; KINASE; Kinase, protein; Protein kinase, CMGC; Protein kinase, Ser/Thr (non-receptor) Q13164 5598 17p11.2 human S567-p 20572700 VLSDNDRsLLERWTR intracellular localization; enzymatic activity, inhibited transcription, altered 20667468 1 2 0 +Dlg4 PSD-95 Adaptor/scaffold P31016 29495 10q24 rat T19-p 3609101 YRYQDEDtPPLEHSP receptor internalization, induced; protein degradation; intracellular localization neural plasticity; autophagy, induced 23864697; 33990590 8 0 0 regulates AMPAR mobility +PIP5K1C PIP5K1C Carbohydrate Metabolism - inositol phosphate; EC 2.7.1.68; Kinase, lipid; Motility/polarity/chemotaxis O60331 23396 19p13.3 human T553-p 487222 QPRYRRRtQSSGQDG protein degradation; intracellular localization cell motility, induced; cell adhesion, induced 27780861 1 4 35 localizing to focal adhesions, indispensable for breast cancer cell invasion +TP53 p53 Activator; DNA-binding; Motility/polarity/chemotaxis; Nuclear receptor co-regulator; Transcription factor; Tumor suppressor P04637 7157 17p13.1 human S269-p 17677100 GNLLGRNsFEVRVCA P53 protein stabilization; ubiquitination; intracellular localization; protein conformation; activity, inhibited apoptosis, altered; transcription, inhibited; transcription, altered; cell growth, altered HSP70(INDUCES) DNA(DISRUPTS) 20847049; 20851891; 20959462 3 1 0 +SNPH syntaphilin iso2 Membrane protein, integral; Vesicle O15079-2 9751 20p13 human S64-p 481340 AGSRRRTsPPVSVRD Syntaphilin cell growth, induced 34087103 1 3 1 +MFN2 MFN2 Cell cycle regulation; Cytoskeletal; EC 3.6.5.-; Hydrolase; Membrane protein, integral; Membrane protein, multi-pass; Mitochondrial O95140 9927 1p36.22 human K192-ub 31067000 NSKCPLLkDDLVLMD Dynamin_N molecular association, regulation; intracellular localization MFN2(INDUCES) 23727017 1 0 0 induces calcium mobilization, induces mitochondria-ER membrane formation (MAM) and MFN2-oligomerization +BAIAP2L1 IRTKS Adaptor/scaffold; Cytoskeletal Q9UHR4 55971 7q21.3-q22.1 human Y163-p 462516 YEHKEIEyVETVTSR IMD cell motility, induced 21840312 1 7 95 +CYTH2 cytohesin 2 GEF; GEF, ARF Q99418 9266 19q13.33 human T276-p 30306600 LGGGRVKtWKRRWFI PH molecular association, regulation; protein conformation signaling pathway regulation 24303080 1 0 0 association with membranes, activation of Arf6 +APC APC Motility/polarity/chemotaxis; Tumor suppressor P25054 324 5q22.2 human S1501-p 999605 ESTPDGFsCSSSLSA APC_r phosphorylation 17910481 1 0 0 phosphorylation by GSK3 primes for S1504 and S1507 phosphorylation by CK1 +GRIN2A NMDAR2A Channel, ligand-gated; Membrane protein, integral; Membrane protein, multi-pass Q12879 2903 16p13.2 human S900-p 2897403 NMLKLLRsAKNISSM NMDAR2_C receptor desensitization, inhibited 23503100 2 0 0 increase in synaptic NR current by phosphorylation of Ser-900, 929 +Slc12a5 KCC2 Membrane protein, integral; Membrane protein, multi-pass; Transporter; Transporter, SLC family Q91V14 57138 2|2 H3 mouse T1029-p 10045602 TDPEVHLtWTKDKSV protein degradation; molecular association, regulation; ubiquitination; activity, inhibited cell growth, altered FBXL4(INDUCES) 31615901; 36973513 9 5 1 necessary for neuronal proliferation and /or migration in developing forebrain +Trpv1 TRPV1 Channel, cation; Membrane protein, integral; Membrane protein, multi-pass; Receptor, misc. Q704Y3 193034 11 B4|11 45.25 cM mouse S801-p 450017 VPLLRDAsTRDRHST receptor desensitization, altered 31676602 21 0 0 Regulates spontaneous pain during masseter inflammation; regulates inflammation mediated sensitization +FOXO1 FOXO1A DNA-binding; Nuclear receptor co-regulator; Oncoprotein; Transcription factor Q12778 2308 13q14.11 human R253-me 5009204 SGKSPRRrAASMDNN protein stabilization; intracellular localization; phosphorylation apoptosis, induced; transcription, induced 18951090 1 0 0 inhibits S256 phosphorylation +Elk1 ELK1 DNA-binding; Transcription factor P41969 13712 X A1.3|X 16.45 cM mouse S384-p 447872 IHFWSTLsPIAPRSP molecular association, regulation; intracellular localization neural plasticity; cell differentiation, altered; cell growth, induced; transcription, induced; cytoskeletal reorganization; transcription, altered; cell growth, altered MED16(INDUCES); MED23(INDUCES); Trap100(INDUCES) DNA(INDUCES) 18160653; 18356083; 21562256; 27738173; 34704358; 35085550; 35902881; 7889942 45 1 0 +MAP4K3 KHS2 EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, STE; Protein kinase, Ser/Thr (non-receptor) Q8IVH8 8491 2p22.1 human S170-p 12655400 ATIAKRKsFIGTPYW Pkinase enzymatic activity, induced 20227368 1 3 8 +LOC100044138 SEPT5 iso2 Cell cycle regulation; Cytoskeletal; Hydrolase; Vesicle XP_001480843 100044138 mouse S17-p 475075 RLVEQLLsPRTQAQR intracellular localization 19937814 2 7 2 +ATM ATM DNA repair, damage; EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, Ser/Thr (non-receptor); Protein kinase, atypical; Tumor suppressor Q13315 472 11q22.3 human S794-p 6413900 LSNCTKKsPNKIASG phosphorylation; enzymatic activity, induced cell cycle regulation; apoptosis, induced 19151707 1 0 0 stimulates phosphorylation of S1981 +Llgl1 LLGL1 Cell adhesion; Cytoskeletal; Motility/polarity/chemotaxis Q80Y17 16897 11 B2|11 37.81 cM mouse S672-p 449918 RIRKSRVsGKKRTPA intracellular localization 11809830 2 1 0 +TP53 p53 Activator; DNA-binding; Motility/polarity/chemotaxis; Nuclear receptor co-regulator; Transcription factor; Tumor suppressor P04637 7157 17p13.1 human K381-ac 458983 GQSTSRHkKLMFKTE protein degradation; molecular association, regulation; protein stabilization; ubiquitination; intracellular localization; protein conformation apoptosis, altered; carcinogenesis, inhibited; cell growth, inhibited; apoptosis, induced; transcription, induced; transcription, altered; cell growth, induced; transcription, inhibited BCL2L2(INDUCES); PC4(INDUCES); p21Cip1(DISRUPTS); p300(INDUCES); p53(DISRUPTS) DNA(INDUCES); DNA(DISRUPTS) 11094089; 11099047; 11250899; 11971195; 12421820; 14982997; 16291740; 18485870; 19339993; 19377469; 21297583; 21586571; 22033337; 22249259; 23678107; 25651062; 31680191; 36257192; 9288740 35 6 0 promoting the C-terminal acetylation of p53 and may facilitate p53-dependent gene expression ; promotes antiviral activity; apoptosis inhibited in cortical neuron and increased in proliferating cancer cells; 20, 164, 305, 320, 370/372/373, 381/382/386 K-R mutants diminsished transactivation, and selective regulation of target genes expression through distinct mechanisms; DNA damage induces p53 acetylation and H1.2 phosphorylation, inducing disassociation and transcription leading to apoptosis or DNA repair. +Bad BAD Apoptosis O35147 64639 1q43 rat S137-p 447862 PFRGRSRsAPPNLWA Bcl-2_BAD activity, induced; molecular association, regulation apoptosis, altered; apoptosis, inhibited 14-3-3 beta(INDUCES); 14-3-3 zeta(INDUCES); Bcl-xL(DISRUPTS) 11493700; 12049737; 12807431; 19344769 124 55 216 +Arhgef26 SGEF GEF; GEF, Rac/Rho D3YYY8 622434 3|3 E1 mouse Y530-p 479144 TFDPYVKyCTNEVYQ RhoGEF molecular association, regulation cell motility, inhibited RHOG(DISRUPTS) 27437949 1 0 1 regulation of SGEF activity and function +NR4A1 Nur77 Apoptosis; DNA-binding; Nuclear receptor P22736 3164 12q13.13 human K102-sm 610814562 SPASASFkFEDFQVY protein degradation; ubiquitination transcription, inhibited 28622293 1 1 0 inhibits TNF-alpha and IL-1beta-induced NF-kB activity +FGFR1 FGFR1 EC 2.7.10.1; KINASE; Kinase, protein; Membrane protein, integral; Oncoprotein; Protein kinase, TK; Protein kinase, tyrosine (receptor) P11362 2260 8p11.23 human Y730-p 448642 SNCTNELyMMMRDCW PK_Tyr_Ser-Thr cell cycle regulation; transcription, altered 9880324 5 1 1 Phosphorylation of either Y463 or Y730, dispensable for mitogenic signaling, represents an absolute requirement for FGF2-mediated uPA induction +DVL2 DVL2 Adaptor/scaffold; Motility/polarity/chemotaxis O14641 1856 17p13.1 human S594-p 22682201 EGSRSSGsTRSDGGA Dsh_C cytoskeletal reorganization; transcription, inhibited 23396967 1 0 0 neurite outgrowth +SUZ12 SUZ12 C2H2-type zinc finger protein; Oncoprotein; Transcription factor Q15022 23512 17q11.2 human S546-p 449173 SMSEFLEsEDGEVEQ VEFS-Box molecular association, regulation; ubiquitination EZH2(DISRUPTS) 25855382 1 52 1 +ZAP70 ZAP70 EC 2.7.10.2; KINASE; Kinase, protein; Protein kinase, TK; Protein kinase, tyrosine (non-receptor) P43403 7535 2q11.2 human S520-p 2861415 FRKFSSRsDVWSYGV PK_Tyr_Ser-Thr intracellular localization; phosphorylation transcription, altered 14560012 1 0 1 increases autophosphorylation +HSPB8 HSPB8 Heat shock protein Q9UJY1 26353 12q24.23 human T87-p 467970 GVPAEGRtPPPFPGE protein conformation 21526341 2 20 0 increase chaperone activity +CASP8 CASP8 Apoptosis; EC 3.4.22.61; Protease Q14790 841 2q33.1 human K156-sm 1876540100 RVILGEGkLDILKRV DED intracellular localization 15782135 1 0 0 +PACSIN1 PACSIN1 Adaptor/scaffold Q9BY11 29993 6p21.31 human S349-p 4730488 GDRGSVSsYDRGQPY molecular association, regulation PICK1(DISRUPTS) 23918399 1 5 0 regulates AMPAR trafficking +DBI DBI Lipid-binding Q8WN94 100008823 rabbit T42-p 2833500 ATVGDVNtERPGMLD ACBP molecular association, regulation GABRA1(INDUCES) 18194441 1 0 0 +FEN1 FEN1 DNA repair, damage; DNA-binding; Deoxyribonuclease; EC 3.1.-.-; Nuclear receptor co-regulator; Nucleolus; Ribonuclease P39748 2237 11q12.2 human K354-ub 15388693 TGSLSSAkRKEPEPK protein degradation; ubiquitination 22749529 1 5 1 +BRAF BRAF EC 2.7.11.1; KINASE; Kinase, protein; Oncoprotein; Protein kinase, Ser/Thr (non-receptor); Protein kinase, TKL P15056 673 7q34 human S729-p 450242 PKIHRSAsEPSLNRA protein stabilization; molecular association, regulation; enzymatic activity, induced cell cycle regulation; cell differentiation, altered; cell growth, inhibited; cell growth, altered 14-3-3 beta(INDUCES); KSR(INDUCES); RAF1(INDUCES) 10660530; 19933846; 24095280; 31929109; 37625591 8 59 25 +KRT18 K18 Cytoskeletal; Nucleolus P05783 3875 12q13.13 human S51-p 3179064 SRISVSRsTSFRGGM intracellular localization cytoskeletal reorganization 23241311; 27403885 2 9 11 phosphorylation reduces keratin filament length, formation of connectivity-depleted and mechanically weaker networks; keratin filament buckling, S51-p is localized in the periphery of the cell. +Nfya NFYA DNA-binding; Transcription factor P23708 18044 17 C|17 23.99 cM mouse K292-ub 4664701 EAEGKIPkERRKYLH CBFB_NFYA protein degradation cell growth, inhibited; transcription, inhibited 18815279 1 0 0 +Wnk4 WNK4 EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, Other; Protein kinase, Ser/Thr (non-receptor) Q80UE6 69847 11|11 D mouse K172-ub 40323312 SPDGRYLkFDIEIGR Pkinase protein degradation 23576762 1 1 0 regulates electrolyte homeostasis and involved in Pseudohypoaldosteronism type II (PHAII) pathogenesis +Plin1 perilipin 1 Lipid-binding Q8CGN5 103968 7|7 D2 mouse S222-p 450080 PSLVRRVsTLANTLS Perilipin molecular association, regulation HSL(INDUCES) 19717842 2 6 4 +SUV39H1 SUV39H1 Amino Acid Metabolism - lysine degradation; EC 2.1.1.43; METHYLTRANSFERASE; Methyltransferase; Methyltransferase, protein lysine O43463 6839 Xp11.23 human K123-m1 63128911 NYLVQKAkQRRALRR enzymatic activity, inhibited chromatin organization, altered; cell growth, inhibited; transcription, induced 23509280 1 1 0 facilitated genomic instability +LDB1 LDB1 iso2 Transcription, coactivator/corepressor Q86U70-2 8861 10q24.32 human K365-ub 1877171202 PPSSQESkSENPTSQ protein degradation 32229578 1 0 0 +DRD1 DRD1 GPCR, family 1; Membrane protein, integral; Membrane protein, multi-pass; Receptor, GPCR P21728 1812 5q35.2 human T360-p 449796 ATNNAIEtVSINNNG receptor desensitization, altered; receptor internalization, altered 11773080 1 0 0 +L1CAM NCAM-L1 Cell adhesion; Membrane protein, integral P32004 3897 Xq28 human S1152-p 449315 RSKGGKYsVKDKEDT Bravo_FIGEY molecular association, regulation cytoskeletal reorganization; cell adhesion, inhibited ANK3(INDUCES) 17151951; 29109170; 8663493 3 1 0 L1 sensitivity to ethanol; implicated in neurite outgrowth +Net1 NET1 GEF; GEF, Rac/Rho; Motility/polarity/chemotaxis; Oncoprotein Q9Z206 56349 13|13 A1 mouse S153-p 455601 TPTKRRSsALWSEML activity, inhibited cytoskeletal reorganization 15684429 1 0 0 inhibits guanine nucleotide exhange activity toward RhoA, inhibits actin stress fiber formation +Thop1 THOP1 EC 3.4.24.15; Protease P24155 64517 7q11 rat S644-p 448213 VGMDYRTsILRPGGS Peptidase_M3 molecular association, regulation; intracellular localization; enzymatic activity, induced 14-3-3 epsilon(INDUCES) 10969067; 15773901 2 1 0 +ACTN4 ACTN4 Cytoskeletal; Motility/polarity/chemotaxis O43707 81 19q13.2 human Y265-p 450725 MTYVSSFyHAFSGAQ CH molecular association, regulation; protein processing; intracellular localization; protein conformation apoptosis, induced; cell motility, inhibited; cytoskeletal reorganization ACTB(DISRUPTS); ACTA1(INDUCES) 19920151; 23454549; 31664084 3 24 506 +Cd300a MAIR-I Immunoglobulin superfamily; Membrane protein, integral Q6SJQ0 217303 11 E2|11 80.54 cM mouse Y274-p 455227 LPQEELHySSVAFNS SIT molecular association, regulation SHIP(INDUCES); SHP-2(INDUCES); SHP-1(INDUCES) 15569773 1 0 6 +CTTN Cortactin Actin-binding; Cytoskeletal; Motility/polarity/chemotaxis Q14247 2017 11q13.3 human K161-ac 482875 YSSGFGGkYGVQADR HS1_rep molecular association, regulation; intracellular localization cell motility, inhibited ACTB(DISRUPTS) 17643370 1 2 10 Acetylation prevents localization to membrane ruf?es. +HMOX1 HMOX1 Cofactor and Vitamin Metabolism - porphyrin and chlorophyll; EC 1.14.99.3; Oxidoreductase P09601 3162 22q12.3 human K243-ac 206219703 LRQRASNkVQDSAPV molecular association, regulation carcinogenesis, induced; cell motility, induced; cell growth, induced JunD(INDUCES) 28846111 1 1 0 Interaction leads to AP-1 transcriptional activation +HTT Huntingtin Cytoskeletal P42858 3064 4p16.3 human S419-p 448106 GGRSRSGsIVELIAG activity, induced; molecular association, regulation apoptosis, induced; apoptosis, inhibited; cytoskeletal reorganization; signaling pathway regulation KIF5B(INDUCES); dynactin 1(INDUCES) 12062094; 14725621; 16452687; 18615096; 18772195; 24505464; 24619418; 32978366 14 32 21 D2R signaling; regulates mitochondrial morphology and function +PRKCI PKCI Cell adhesion; Cell development/differentiation; EC 2.7.11.13; KINASE; Kinase, protein; Motility/polarity/chemotaxis; Oncoprotein; Protein kinase, AGC; Protein kinase, Ser/Thr (non-receptor); Tumor suppressor P41743 5584 3q26.2 human T412-p 454434 RPGDTTStFCGTPNY Pkinase enzymatic activity, induced 15604232; 21281788 9 15 36 +Mob1a MOB1A Protein kinase, regulatory subunit Q921Y0 232157 6|6 C3 mouse S146-p 1214257701 PFPKNFMsVAKTILK Mob1_phocein protein degradation; ubiquitination cell growth, induced 30069702 1 0 0 induces neurite outgrowth and regulates functional recovery after SCI +SARS1 SARS Aminoacyl-tRNA synthetase; EC 6.1.1.11; Ligase; RNA processing; Translation; Translation regulation P49591 6301 1p13.3 human S241-p 482693 MQEVAQLsQFDEELY molecular association, regulation carcinogenesis, induced; cell growth, induced; transcription, induced DNA(DISRUPTS) 33351793 1 1 0 +Nfatc2 NFAT1 DNA-binding; Transcription factor Q60591 18019 2 H3|2 88.91 cM mouse K684-ub 1852795101 YHPVPAIkTEPSDEY protein degradation 21628454 1 0 0 in NFAT1 S215/219/223A triple mutant or when phosphorylation of those sites is inhibited by zoledronic acid +PITX1 PITX1 Cell development/differentiation; DNA-binding; Transcription factor P78337 5307 5q31.1 human Y179-p 54204603 EDVYAAGySYNNWAA protein degradation; protein stabilization transcription, inhibited 26840794; 27752061 2 0 0 +BCL2L1 Bcl-xL Apoptosis; Autophagy; Membrane protein, integral; Mitochondrial Q07817 598 20q11.21 human S49-p 21336504 ESEMETPsAINGNPS protein conformation cell cycle regulation; cell growth, inhibited 21840391; 27398719; 28486788 3 0 0 growth inhibited in both SA and SD mutants; stabilizes G2 arrest; enables cytokinesis and mitotic exit +APBB1 Fe65 Adaptor/scaffold; Apoptosis; Transcription regulation O00213 322 11p15.4 human S228-p 36841900 DSSWATLsQGSPSYG transcription, inhibited 25397632 2 0 0 inhibits transcriptional activity of APP in the Fe65-APP complex +Ywhaz 14-3-3 zeta Adaptor/scaffold; Motility/polarity/chemotaxis P63101 22631 15|15 B3.1 mouse Y179-p 7316700 LNFSVFYyEILNSPE 14-3-3 molecular association, regulation; phosphorylation SHC1(INDUCES) 19218246 1 1 0 important for the phosphorylation of Akt and cytokine-mediated cell survival +Ubtf UBF DNA-binding; Nucleolus; Transcription factor P25977 25574 10q32.1 rat T117-p 448504 DFPKKPLtPYFRFFM HMG_box transcription, inhibited 11741541 1 6 13 +TUSC2 TUSC2 Tumor suppressor O75896 11334 3p21.31 human K71-ub 1881852004 YEETIVTkNGQKRAK protein degradation apoptosis, induced 35167936 1 0 0 TUSC2-K71R significantly increased GSC-28 neurosphere apoptosis compared to WT +NUP98 NUP98 iso2 Motility/polarity/chemotaxis; Nucleoporin P52948-2 4928 11p15.4 human S861-p 18330804 GSWVFKVsHFSKYGL Nucleoporin2 intracellular localization 21335236 1 1 0 as multiple sites (13PM) mutant +Il4r IL4R Membrane protein, integral; Receptor, cytokine P16382 16190 7 F3|7 68.94 cM mouse Y500-p 451065 VLADNPAyRSFSDCC activity, induced; phosphorylation cell cycle regulation 14557412; 16210622 3 0 0 Akt and p70S6K phosphorylation +SALL4 SALL4 iso3 C2H2-type zinc finger protein; Cancer Testis Antigen (CTA); DNA-binding Q9UJQ4-2 57167 20q13.2 human K156-sm 31089512 AESVVYLkTETALPP protein stabilization; molecular association, regulation; intracellular localization transcription, induced Oct4(DISRUPTS) 23012367 1 0 0 +Ppargc1b PGC-1 beta Nuclear receptor co-regulator; Transcription, coactivator/corepressor Q8VHJ7 170826 18|18 E1 mouse K469-ac 7761209 PWTKLGRkMDSSVCP intracellular localization transcription, inhibited 19491097 1 1 0 +Mlxipl ChREBP Transcription factor Q99MZ3 58805 5|5 G2 mouse K672-ac 18609101 THISAEQkRRFNIKL HLH molecular association, regulation transcription, induced DNA(INDUCES) 25761756 2 0 0 +ILF3 NFAT90 DNA-binding; Nucleolus; RNA-binding; Transcription factor Q12906 3609 19p13.2 human S482-p 449210 DSSKGEDsAEETEAK protein stabilization cell cycle regulation 21401756 1 41 10 +IRAK4 IRAK4 EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, Ser/Thr (non-receptor); Protein kinase, TKL Q9NWZ3 51135 12q12 human T342-p 2045344 ASEKFAQtVMTSRIV PK_Tyr_Ser-Thr enzymatic activity, induced 17141195; 17312103 3 3 0 +NAA50 NAA50 ACETYLTRANSFERASE; Acetyltransferase; EC 2.3.1.- Q9GZZ1 80218 3q13.31 human K37-ac 461832 SYNDKFYkDVLEVGE Acetyltransf_1 acetylation; enzymatic activity, induced 19744929 1 8 63 reduces histone acetylation and increases NAT activity, thereby increasing enzyme specificity +DUSP4 DUSP4 EC 3.1.3.16; EC 3.1.3.48; PHOSPHATASE; Protein phosphatase, dual-specificity Q13115 1846 8p12 human S386-p 15412243 SSLPYLHsPITTSPS protein stabilization 25204653 2 1 2 +RPS3 RPS3 Apoptosis; EC 4.2.99.18; RNA-binding; Ribosomal; Translation P23396 6188 11q13.4 human T221-p 452652 KDEILPTtPISEQKG activity, induced; intracellular localization translation, altered 19059439; 21871177 4 100 99 nuclear accumulation; important for a cell survival in the stress condition +BLNK BLNK Adaptor/scaffold Q8WV28 29760 10q24.1 human Y189-p 447717 VEDNDENyIHPTESS molecular association, regulation transcription, altered PLCG1(INDUCES); Btk(INDUCES); NCK2(INDUCES); VAV1(INDUCES) 12456653 1 2 4 Sites mutated alone and in combination (Y189,Y178and Y96) prevented binding of PLCG1 and mobization of Ca2+. For NF-AT transcriptional activity Y103,Y194 and Y205 residues were necessary.Tyrosine phosphoryation of BLNK induces MAPK activation. +Pgk1 PGK1 Carbohydrate Metabolism - glycolysis and gluconeogenesis; EC 2.7.2.3; KINASE; Kinase, other P09411 18655 X D|X 47.36 cM mouse S203-p 468410 YFAKALEsPERPFLA PGK signaling pathway regulation 36963288 3 83 11 regulates the Keap1-Nrf2 signaling pathway +Plk4 PLK4 EC 2.7.11.21; KINASE; Kinase, protein; Nucleolus; Protein kinase, Other; Protein kinase, Ser/Thr (non-receptor) Q64702 20873 3|3 B mouse T293-p 12654011 GHATLSTtITASSGT protein degradation; ubiquitination 20100909 1 1 0 +CXADR CXADR Cell adhesion; Membrane protein, integral; Receptor, misc. P78310 1525 21q21.1 human T290-p 801662702 PPKSRTStARSYIGS molecular association, regulation; intracellular localization KIF22(INDUCES) 29382784 1 0 0 translocation within cell junctions in response to EGF +PAX3 PAX3 DNA-binding; Oncoprotein; Transcription factor P23760 5077 2q36.1 human S201-p 18744500 ERASAPQsDEGSDID cell growth, inhibited; cell motility, inhibited 25821947 4 2 0 +Scrib Scribble iso3 Cell adhesion; Motility/polarity/chemotaxis Q80U72-3 105782 15 D3|15 35.29 cM mouse S1601-p 449228 RPVYDIQsPDFVEEL molecular association, regulation; intracellular localization cell adhesion, altered CDH1(DISRUPTS) 21146521 1 47 6 interaction with E-cadherin-catenin complex +FOXO1 FOXO1A DNA-binding; Nuclear receptor co-regulator; Oncoprotein; Transcription factor Q12778 2308 13q14.11 human S22-p 1869008600 EPLPRPRsCTWPLPR activity, induced; molecular association, regulation; intracellular localization; phosphorylation transcription, altered; transcription, inhibited; signaling pathway regulation 14-3-3 beta(DISRUPTS) 31308176; 34646017 2 1 0 +Arhgap35 GRF-1 GAP; GAP, Rac/Rho; Motility/polarity/chemotaxis; Transcription factor; Tumor suppressor Q91YM2 232906 7|7 A2 mouse Y308-p 455312 ASPEYQDyVYLEGTQ RhoGAP-FF1 molecular association, regulation GTF2I(DISRUPTS) 15629714 2 0 0 +Nrip1 RIP140 Nuclear receptor co-regulator; Transcription, coactivator/corepressor Q8CBD1 268903 16|16 C3.1 mouse K591-me 6742801 ACSTPASkLTNTAPS NRIP1_repr_2 molecular association, regulation; methylation transcription, inhibited HDAC3(INDUCES) 19216533 1 1 0 inhibits arginine methylation +Rb1 Rb Nuclear receptor co-regulator; Oncoprotein; Transcription, coactivator/corepressor; Tumor suppressor P13405 19645 14 38.73 cM|14 D3 mouse T350-p 447981 DSFETERtPRKNNPD molecular association, regulation cell cycle regulation; cell growth, induced; transcription, inhibited E2F1(DISRUPTS) 10207050; 35023164; 9671466 15 19 36 transcriptional downregulation of the E2F-1, E2F-2, dihydrofolate reductase, thymidine kinase, c-myc, proliferating-cell nuclear antigen, p107, and p21/Cip1 genes +Mapk14 P38A EC 2.7.11.24; KINASE; Kinase, protein; Protein kinase, CMGC; Protein kinase, Ser/Thr (non-receptor) P70618 81649 20p12 rat Y182-p 447971 TDDEMTGyVATRWYR Pkinase activity, induced; enzymatic activity, induced apoptosis, induced; cell growth, altered 10473611; 25371038; 28039298 410 123 3683 +Foxo4 FOXO4 DNA-binding; Oncoprotein; Transcription factor Q9WVH3 54601 X D|X 43.89 cM mouse S197-p 448516 APRRRAAsMDSSSKL molecular association, regulation transcription, altered 14-3-3 zeta(INDUCES) 14690436 13 5 6 +OPN3 encephalopsin GPCR, family 1; Membrane protein, integral; Membrane protein, multi-pass; Receptor, GPCR Q9H1Y3 23596 1q43 human Y140-p 23257062 TVLAYERyIRVVHAR 7tm_1 carcinogenesis, induced 35180853 1 0 1 +RPL36A RPL36A P83881 6173 Xq22.1 human K53-m1 8106909 SGYGGQTkPIFRKKA Ribosomal_L44 molecular association, regulation ETF1(INDUCES) 28567122 1 6 36 +UVRAG UVRAG Autophagy Q9P2Y5 7405 11q13.5 human K559-ub 3937122 DTSLDFSkENKKKGE autophagy, induced 30686098 1 0 1 +RNF2 RNF2 EC 6.3.2.-; EC 6.3.2.19; Ligase; UBIQUITIN LIGASE; Ubiquitin conjugating system; Ubiquitin ligase Q99496 6045 1q25.3 human S41-p 7670101 DGLEIVVsPRSLHSE transcription, altered 19405034 1 15 2 +Lipe HSL EC 3.1.1.79; Lipase P54310 16890 7 A3|7 13.78 cM mouse S559-p 448804 ESMRRSVsEAALAQP phosphorylation 19942859 27 28 1 inhibits phosphorylation at S557 +RALA RALA G protein; G protein, monomeric; G protein, monomeric, Ras; Motility/polarity/chemotaxis P11233 5898 7p14.1 human S194-p 483989 NGKKKRKsLAKRIRE molecular association, regulation; intracellular localization; enzymatic activity, induced carcinogenesis, induced; cell growth, induced; cytoskeletal reorganization; cell growth, altered RALBP1(NOT_REPORTED) 17540176; 19901077 5 1 1 localization to plasma membrane +PARD6A PARD6A Adaptor/scaffold; Cell adhesion; Motility/polarity/chemotaxis Q9NPB6 50855 16q22.1 human S345-p 15714600 RGDGSGFsL______ protein degradation cell motility, induced; cytoskeletal reorganization 23249950 2 9 0 phosphorylation necessary to induce Epithelial to mesenchymal transition (EMT) and RhoA degradation, TGF? induced E-cadherin loss, stress fiber formation +Per2 PER2 Nuclear receptor co-regulator; Nucleolus; Transcription factor O54943 18627 1|1 D mouse S478-p 50596800 PVPHSGSsGYGSLGS protein degradation; molecular association, regulation BTRC(INDUCES) 26431025; 28545154 4 0 0 +Ube2j1 UBE2J1 EC 6.3.2.19; Membrane protein, integral; UBIQUITIN LIGASE; Ubiquitin conjugating system; Ubiquitin ligase Q9JJZ4 56228 4|4 A5 mouse S184-p 465537 KELARQIsFKAEVNS translation, induced 24020373 3 13 52 TNF-alpha synthesis +POLH POLH DNA repair, damage; EC 2.7.7.7; Transferase Q9Y253 5429 6p21.1 human S587-p 5024701 GVSKLEEsSKATPAE intracellular localization DNA repair, induced; cell growth, altered 18946034; 35339488 2 0 0 +MRE11 MRE11A Cell cycle regulation; DNA repair, damage; DNA-binding; Deoxyribonuclease P49959 4361 11q21 human S531-p 5846030 TRARALRsQSEESAS molecular association, regulation DNA(DISRUPTS) 19709933 1 0 1 +LIG1 LIG1 DNA repair, damage; EC 6.5.1.1; Ligase P18858 3978 19q13.33 human S66-p 448498 KAARVLGsEGEEEDE molecular association, regulation; intracellular localization cell growth, altered RFC1(INDUCES); RAD17(DISRUPTS) 12851383; 19223468 4 54 6 regulates DNA replication and repair +BMX Etk EC 2.7.10.2; KINASE; Kinase, protein; Protein kinase, TK; Protein kinase, tyrosine (non-receptor) P51813 660 Xp22.2 human Y40-p 448066 LTKTNLSyYEYDKMK PH molecular association, regulation; intracellular localization; enzymatic activity, induced cell motility, altered; cytoskeletal reorganization FAK(INDUCES) 11331870 5 0 0 +Hnrnpa3 hnRNP A3 RNA splicing; RNA-binding; Spliceosome Q8BG05 229279 2|2 C3 mouse S359-p 483226 FGGRSSGsPYGGGYG molecular association, regulation RNA(DISRUPTS) 20885981 1 78 82 +Chek1 Chk1 EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, CAMK; Protein kinase, Ser/Thr (non-receptor); Tumor suppressor O35280 12649 9|9 A4 mouse S286-p 465527 TSGGMSEsSSGFSKH intracellular localization 19837665 5 12 14 +REL REL Oncoprotein; Transcription factor Q04864 5966 2p16.1 human S503-p 453447 VNMMTTSsDSMGETD apoptosis, inhibited; transcription, induced; transcription, altered 10823840; 16027730 2 0 0 S503A mutation enhances REL's transforming activity in vitro, while S503D mutation inhibits it. +ACKR3 CMKOR1 GPCR, family 1; Membrane protein, integral; Membrane protein, multi-pass; Receptor, GPCR P25106 57007 2q37.3 human S355-p 4709319 RVSETEYsALEQSTK receptor internalization, induced; molecular association, regulation; intracellular localization ARRB1(INDUCES) 33799570 1 6 7 +Cdkn2c CDKN2C Cell cycle regulation; Inhibitor; Protein kinase, regulatory subunit Q60772 12580 4 C7|4 51.32 cM mouse K46-ub 6423506 RTALQVMkLGNPEIA protein degradation 19029828 1 0 5 +PTPN11 SHP-2 iso1 EC 3.1.3.48; Motility/polarity/chemotaxis; PHOSPHATASE; Protein phosphatase, tyrosine (non-receptor) Q06124-1 5781 12q24.13 human K594-sm 40709500 VGLMQQQkSFR____ molecular association, regulation; intracellular localization; phosphorylation carcinogenesis, induced; signaling pathway regulation GAB1(INDUCES) 25823821 1 0 0 induces ERK phosphorylation, regulates ERK signaling pathway +Trpv1 TRPV1 Channel, cation; Membrane protein, integral; Membrane protein, multi-pass; Receptor, misc. O35433 83810 10q24 rat S800-p 450017 VPLLRDAsTRDRHAT activity, induced; receptor desensitization, inhibited; molecular association, regulation; receptor desensitization, altered cytoskeletal reorganization TUBA1A(DISRUPTS) 12761211; 14523239; 14973326; 15003856; 18001466; 18391945; 18495351; 21480900; 22933780; 25451626; 32345612 21 0 0 +Igf1r IGF1R EC 2.7.10.1; KINASE; Kinase, protein; Membrane protein, integral; Protein kinase, TK; Protein kinase, tyrosine (receptor) Q60751 16001 7 C|7 37.27 cM mouse Y1163-p 448386 FGMTRDIyETDYYRK PK_Tyr_Ser-Thr intracellular localization; enzymatic activity, induced cell cycle regulation; cell growth, induced; cell differentiation, induced; cell motility, altered 18515860; 23954591; 34158399; 8940173 22 31 455 +ATP5F1A ATP5A1 EC 3.6.3.14; Energy Metabolism - oxidative phosphorylation; Hydrolase; Membrane protein, integral; Mitochondrial; Transporter P25705 498 18q21.1 human Y246-p 477314 KKKLYCIyVAIGQKR ATP-synt_ab molecular association, regulation; phosphorylation carcinogenesis, induced; cell growth, induced; apoptosis, inhibited; autophagy, inhibited ATPIF1(DISRUPTS) 35895804 1 1 2 inhibits phosphorylation of downstream proteins +Prkn PARK2 EC 6.3.2.-; EC 6.3.2.19; Ligase; Translation; Translation regulation; UBIQUITIN LIGASE; Ubiquitin conjugating system; Ubiquitin ligase Q9WVS6 50873 17 A1|17 7.8 cM mouse S131-p 454421 DTDSKRDsEAARGPV protein stabilization; ubiquitination; enzymatic activity, inhibited 32379419 5 3 0 decrease DMT1 ubiquitination and increase DMT1 protein stabilization +CEBPE C/EBP-epsilon DNA-binding; Motility/polarity/chemotaxis; Transcription factor Q15744 1053 14q11.2 human K198-ac 38557702 GPLHKGKkAVNKDSL cell differentiation, induced; transcription, induced 25568349; 31256937 2 1 0 deletion of R247 or S248 was sufficient for the loss of C/EBPe transcriptional activity, TSA treatment may be able restore the transcriptional activity +Htr1a 5-HT(1A) GPCR, family 1; Membrane protein, integral; Membrane protein, multi-pass; Receptor, GPCR P19327 24473 2q13 rat T149-p 467261 IDYVNKRtPRRAAAL 7tm_1 receptor desensitization, induced; receptor inactivation, altered 11773315; 23510743 2 0 0 +ATF6 ATF6A Membrane protein, integral; Transcription factor P18850 22926 1q23.3 human T166-p 35527100 NKTENGLtPKKKIQV protein degradation; molecular association, regulation; intracellular localization cell cycle regulation; autophagy, induced; cell differentiation, induced; transcription, induced EBP(INDUCES) DNA(INDUCES) 25135476; 37239128 2 2 0 +CENPQ CENPQ Q7L2Z9 55166 6p12.3 human S139-p 31868909 EDLTNVSsLLNMERA CENP-Q molecular association, regulation; intracellular localization DNA(DISRUPTS) 25670858 1 1 0 CENPQ phosphorylation promotes the delocalization of the PBIP1-CENPQ complex from kinetochores +Adcy2 ADCY2 Adenylyl cyclase; EC 4.6.1.1; Lyase; Membrane protein, integral; Membrane protein, multi-pass; Nucleotide Metabolism - purine; Transporter; Transporter, aquaporin family P26769 81636 1p11 rat S871-p 451125 AEHFLARsLKNEELY activity, induced 9366262 1 0 0 +KDM5B JARID1B Cancer Testis Antigen (CTA); DEMETHYLASE; Demethylase; EC 1.14.11.-; Oxidoreductase; Transcription, coactivator/corepressor Q9UGL1 10765 1q32.1 human K278-sm 31089529 KEMKSSIkQEPIERK molecular association, regulation; enzymatic activity, induced transcription, induced DNA(DISRUPTS) 23970103 1 1 0 regulates JARID1B demethylase activity +PKP1 plakophilin 1 Cell adhesion; Motility/polarity/chemotaxis Q13835 5317 1q32.1 human S174-p 27717303 LRKGTLGsKGQKTTQ activity, induced; protein stabilization cell motility, induced; cell growth, induced; translation, induced; cell adhesion, inhibited 23444369 1 1 0 +DTNBP1 DTNBP1 Vesicle Q96EV8 84062 6p22.3 human S299-p 40721501 RAKPPSSsSTCTDSA Dysbindin protein degradation; ubiquitination cell growth, inhibited; transcription, inhibited 30062698 1 1 0 phosphorylation inhibits cofilin transcription and does not reduce surface NR2A levels +Pdcl PhLP G protein regulator, misc. Q63737 64013 3q11 rat S20-p 448825 LQYYYSTsEDEDSDH activity, inhibited 12466282 4 6 3 +SMAD1 SMAD1 DNA-binding; Transcription factor Q15797 4086 4q31.21 human S462-p 448361 GSPHNPIsSVS____ activity, induced; molecular association, regulation; intracellular localization transcription, altered SMAD4(INDUCES) 9136927; 9335504 2 4 4 +BSG BSG Immunoglobulin superfamily; Membrane protein, integral P35613 682 19p13.3 human K366-ub 12324673 DAGSAPLkSSGQHQN carcinogenesis, induced; cell motility, induced; cell growth, induced; transcription, induced 26769849 1 4 8 +CDC25B CDC25B EC 3.1.3.48; Motility/polarity/chemotaxis; Nuclear receptor co-regulator; PHOSPHATASE; Protein phosphatase, dual-specificity P30305 994 20p13 human S353-p 452008 VQNKRRRsVTPPEEQ M-inducer_phosp cell cycle regulation 15128871; 16082213; 23708659 8 13 9 +ZNF746 PARIS C2H2-type zinc finger protein; Transcription regulation Q6NUN9 155061 7q36.1 human K189-sm 580826722 PDLLMQIkQEGELQL transcription, inhibited 31856708; 33077496 2 2 0 +Wnk1 WNK1 EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, Other; Protein kinase, Ser/Thr (non-receptor) P83741 232341 6|6 F1 mouse S378-p 456474 LATLKRAsFAKSVIG Pkinase phosphorylation; enzymatic activity, induced 34289367 3 7 0 induces NKCC1 phosphorylation +Sod2 SOD2 EC 1.15.1.1; Mitochondrial; Oxidoreductase P09671 20656 17 A1|17 8.75 cM mouse K122-me 1872904400 GELLEAIkRDFGSFE Sod_Fe_C cell cycle regulation 22710435 1 1 0 quiescent fibroblasts are dimethylated at K122, and R197 and are also dimethylated in proliferating cells +WASF2 WAVE2 Actin-binding; Motility/polarity/chemotaxis Q9Y6W5 10163 1p36.11 human S351-p 18715500 PGTPPPPsPPSFPPH molecular association, regulation cell motility, altered; cytoskeletal reorganization 21419341 3 0 0 regulates WRC (WAVE2 regulatory complex) interaction with Arp2/3 and lamellipodial protrusion +PIK3AP1 BCAP Adaptor/scaffold Q9DDT2 374268 chicken Y463-p 449909 PGAPEDLyVEMLQSK molecular association, regulation PIK3R1(INDUCES) 11163197 2 0 0 +Stat3 STAT3 DNA-binding; Motility/polarity/chemotaxis; Nuclear receptor co-regulator; Transcription factor P42227 20848 11 D|11 63.82 cM mouse Y705-p 448192 DPGSAAPyLKTKFIC activity, induced; acetylation; molecular association, regulation; ubiquitination; intracellular localization; phosphorylation cell cycle regulation; carcinogenesis, induced; carcinogenesis, inhibited; carcinogenesis, altered; apoptosis, induced; cell growth, inhibited; cell motility, induced; transcription, induced; signaling pathway regulation; transcription, altered; cell differentiation, induced; cell growth, induced; apoptosis, inhibited; transcription, inhibited; cell growth, altered PDGFRA(INDUCES); SIRT1(INDUCES); STAT3(INDUCES) DNA(INDUCES) 11278353; 11751994; 12684046; 15218058; 15705584; 15852015; 15923602; 16205632; 16247467; 18795895; 19295512; 20185553; 21575863; 24526685; 25119572; 25584415; 26479789; 26675719; 26923837; 30573679; 31924651; 31934850; 32475380; 33323974; 33539470; 33664496; 33947971; 33972660; 33985537; 34038731; 34117031; 34168048; 34380027; 34404751; 34530865; 35145233; 35411090; 35732128; 35756080; 35806005; 36088505; 36179418; 36400972; 36450257; 36688918; 36934646; 36976181; 37370133; 9234724; 9531474 541 75 3065 +CASP8 CASP8 iso4 Apoptosis; EC 3.4.22.61; Protease Q14790-4 841 2q33.1 human Y397-p 460647 TDSEEQPyLEMDLSS Peptidase_C14 enzymatic activity, induced 27101103 10 3 35 Src activated by CASP8 Y397 and Y465 phosphorylation +FERMT2 kindlin-2 Cytoskeletal; Motility/polarity/chemotaxis Q96AC1 10979 14q22.1 human S186-p 15226813 YSSPGLYsKTMTPTY protein degradation; molecular association, regulation; ubiquitination cell cycle regulation; cell growth, induced; apoptosis, inhibited; cytoskeletal reorganization; cell adhesion, inhibited CUL9(INDUCES) 35469017 1 2 1 +MCL1 MCL1 Apoptosis; Channel, misc.; Inhibitor; Membrane protein, integral; Mitochondrial Q07820 4170 1q21.2 human T92-p 4825134 EVPDVTAtPARLLFF protein degradation; protein stabilization; molecular association, regulation; ubiquitination cell cycle regulation; apoptosis, altered; carcinogenesis, inhibited; apoptosis, induced; cell growth, altered PIN1(INDUCES) 18676833; 20526282; 21368834; 26205817; 26219338; 27738316; 28751497 7 3 2 +SLC9A1 NHE1 Membrane protein, integral; Membrane protein, multi-pass; Motility/polarity/chemotaxis; Transporter; Transporter, SLC family P19634 6548 1p36.11 human S648-p 3880766 KTRQRLRsYNRHTLV NEXCaM_BD molecular association, regulation; activity, inhibited Calmodulin(DISRUPTS) 18757828; 33655882 4 2 6 +Kcnd2 Kv4.2 Channel, potassium; Membrane protein, integral; Membrane protein, multi-pass Q63881 rat S459-p 2906104 LLSNQLQsSEDEPAF protein stabilization 15071113 1 0 0 +CDC14A CDC14A EC 3.1.3.16; EC 3.1.3.48; Motility/polarity/chemotaxis; PHOSPHATASE; Protein phosphatase, dual-specificity Q9UNH5 8556 1p21.2 human S429-p 5276069 KGHPRAVsQPFRLSS phosphorylation cell cycle regulation 31722221 1 1 1 induces phosphorylation of its substrates by inhibiting its activity +NHE-3 NHE3 Membrane protein, integral; Membrane protein, multi-pass; Transporter; Transporter, SLC family P26432 100009430 rabbit S554-p 450899 TEGERRGsLAFIRSP intracellular localization; activity, inhibited 25480791 27 5 4 decreased surface expression of NHE3, phosphorylation of this site with other 2 sites are together necessary for activity inhibition +POU5F1 Oct4 DNA-binding; Transcription factor Q01860 5460 6p21.33 human K222-me 1881459302 ENLQEICkAETLVQA protein degradation cell differentiation, inhibited; transcription, inhibited 33986438 1 1 0 proteasome-independent degradation; represses the transcription of PORE-motif-containing target genes in vivo and the differentiation capacity of PSCs +CELF1 CELF1 Cell development/differentiation; RNA processing; RNA-binding Q92879 10658 11p11.2 human S241-p 29668004 LLQQTASsGNLNTLS RNA splicing, altered 24151077 1 1 0 splicing regulation in diabetes +NCOA3 SRC-3 ACETYLTRANSFERASE; Acetyltransferase; EC 2.3.1.48; Motility/polarity/chemotaxis; Nuclear receptor co-regulator; Transcription, coactivator/corepressor Q9Y6Q9 8202 20q13.12 human T1059-p 4252801 ALLDQLHtLLSNTDA Nuc_rec_co-act protein stabilization; molecular association, regulation PSMA3(DISRUPTS) 18313384 1 0 0 some subset of these 8 residues +Ldhb LDH-B Amino Acid Metabolism - cysteine and methionine; Carbohydrate Metabolism - glycolysis and gluconeogenesis; Carbohydrate Metabolism - propanoate; Carbohydrate Metabolism - pyruvate; EC 1.1.1.27; Oxidoreductase P16125 16832 6 G2|6 74.17 cM mouse K82-ac 466168 TPKIVADkDYSVTAN Ldh_1_N enzymatic activity, inhibited 33248168 2 6 3 inhibited lactate clearance +FUS hnRNP P2 DNA-binding; Nuclear receptor co-regulator; Oncoprotein; RNA splicing; RNA-binding; SUMO LIGASE P35637 2521 16p11.2 human S54-p 283458502 TSGYGQSsYSSYGQS molecular association, regulation 28942918 1 1 0 strongly reduced the effects of DNA-PK treatment on both hydrogel binding and droplet formation +THRB TR-beta1 DNA-binding; Nuclear receptor P10828 7068 3p24.2 human K443-sm 27490402 ASRFLHMkVECPTEL Hormone_recep molecular association, regulation; intracellular localization cell growth, induced; cell differentiation, induced; transcription, induced; signaling pathway regulation; transcription, altered N-CoR1(DISRUPTS); CBP(DISRUPTS); Src(INDUCES); N-CoR1(INDUCES) DNA(INDUCES); DNA(DISRUPTS) 22930759; 25572392; 27843805 3 0 0 +EGFR EGFR EC 2.7.10.1; KINASE; Kinase, protein; Membrane protein, integral; Oncoprotein; Protein kinase, TK; Protein kinase, tyrosine (receptor) P00533 1956 7p11.2 human K970-ub 1065301 ELIIEFSkMARDPQR receptor recycling, inhibited; protein degradation 16543144; 17940017 2 4 0 +NCOR2 SMRT Nuclear receptor co-regulator; Transcription, coactivator/corepressor Q9Y618 9612 12q24.31 human S2426-p 6422852 ASGDRPPsVSSVHSE protein degradation; ubiquitination; intracellular localization transcription, induced; signaling pathway regulation 22888005 1 1 0 activates Notch1 signaling in intact cells +Ppp1r1b DARPP-32 Motility/polarity/chemotaxis; Protein phosphatase, regulatory subunit Q6J4I0 360616 10q31 rat T75-p 448048 RPNPCAYtPPSLKAV DARPP-32 transcription, altered 15066157 38 6 16 Cocaine sensitized rats showed increased phosphorylation at T75 and decreased at T34, as well as increased Cdk5 expression. +AKT1 Akt1 EC 2.7.11.1; KINASE; Kinase, protein; Oncoprotein; Protein kinase, AGC; Protein kinase, Ser/Thr (non-receptor) P31749 207 14q32.33 human K20-ac 1874844900 HKRGEYIkTWRPRYF PH enzymatic activity, inhibited signaling pathway regulation 28462918; 34965411 3 0 0 activation of dynamin-related protein 1 (DRP1), metabolic reprogramming, glycolytic switching +CDC37 CDC37 Chaperone Q16543 11140 19p13.2 human Y4-p 34490407 ____MVDySVWDHIE CDC37_N molecular association, regulation 22727666 1 0 0 +PAK2 PAK2 EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, STE; Protein kinase, Ser/Thr (non-receptor) Q13177 5062 3q29 human T134-p 15413019 LKFYDSNtVKQKYLS phosphorylation cell cycle regulation; carcinogenesis, induced; cell growth, induced; signaling pathway regulation 32483448 1 5 8 induces phosphorylation of mEK and ERK, induces MAPK signaling pathway +EDNRA EDNRA GPCR, family 1; Membrane protein, integral; Membrane protein, multi-pass; Motility/polarity/chemotaxis; Receptor, GPCR P25101 1909 4q31.22-q31.23 human S393-p 2911710 CCCYQSKsLMTSVPM receptor desensitization, induced 24064210 1 1 0 Lack of S397, T403 and S404 influences desensitization to a greater extent compared than S391, S393, and T396 +Nefl NFL Cytoskeletal P08551 18039 14|14 D1 mouse S42-p 457402 TARSAYSsYSAPVSS Filament_head molecular association, regulation; intracellular localization 14-3-3 gamma(INDUCES) 23230147 3 0 1 regulates NF-L dynamic exchange rate and neurofilament disassembly +MDM2 MDM2 EC 6.3.2.-; EC 6.3.2.19; Inhibitor; Ligase; NEDDYLATION LIGASE; Neddylation Ligase; Nucleolus; Oncoprotein; UBIQUITIN LIGASE; Ubiquitin conjugating system; Ubiquitin ligase Q00987 4193 12q15 human T158-p 27620700 HLVSRPStSSRRRAI protein degradation 23132866 1 0 0 increases MDM2 association with AR via Ser-186 +MDM4 MDM4 EC 6.3.2.-; Ligase; UBIQUITIN LIGASE; Ubiquitin conjugating system; Ubiquitin ligase O15151 4194 1q32.1 human S289-p 456471 DDLEDSKsLSDDTDV molecular association, regulation transcription, inhibited p53(INDUCES); MDM2(INDUCES) 16024788; 23028042; 27114532 5 0 0 +BECN1 beclin 1 Adaptor/scaffold; Autophagy; Membrane protein, peripheral Q14457 8678 17q21.31 human K437-ac 63237403 KFMLTNLkWGLAWVS APG6 protein stabilization; molecular association, regulation; acetylation carcinogenesis, inhibited; autophagy, induced; cell growth, induced; apoptosis, inhibited; autophagy, inhibited rubicon(INDUCES) 26008601; 29088823 2 2 0 CK1 phosphorylation primes for Beclin 1 acetylation; aspirin treatment +TVB5 TVB5 P04213 mouse S78-p 25573800 GYKASRPsQENFSLI V-set activity, induced 12680588 1 0 0 IL-2 secretion in response superantigen staphylococcal enterotoxin B (SEB) binding +Grik2 GluR6 Channel, calcium; Channel, ligand-gated; Membrane protein, integral; Membrane protein, multi-pass P39087 14806 10 B3|10 24.87 cM mouse S868-p 478417 MVEELRMsLKCQRRL intracellular localization 19920140 7 0 0 +PAK1 PAK1 EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, STE; Protein kinase, Ser/Thr (non-receptor) Q13153 5058 11q13.5-q14.1 human S199-p 448172 PRPEHTKsVYTRSVI intracellular localization; protein conformation; enzymatic activity, induced cell motility, altered; cell adhesion, altered 19574218 16 0 0 recruitment to the plasma membrane +EMD emerin Cytoskeletal; Membrane protein, integral P50402 2010 Xq28 human Y4-p 3071455 ____MDNyADLSDTE LEM molecular association, regulation BAF(DISRUPTS) 19789182 1 2 1 +CALR Calreticulin ACETYLTRANSFERASE; Acetyltransferase; Calcium-binding; Motility/polarity/chemotaxis; Nuclear receptor co-regulator; Secreted; Secreted, signal peptide P27797 811 19p13.13 human K64-ac 4219814 YGDEEKDkGLQTSQD Calreticulin protein conformation 18795239 1 1 0 +Bad BAD Apoptosis Q61337 12015 19|19 A mouse S155-p 447863 GRELRRMsDEFEGSF Bcl-2_BAD molecular association, regulation; intracellular localization apoptosis, altered; apoptosis, inhibited 14-3-3 gamma(INDUCES); Bcl-xL(DISRUPTS) 10837473; 10837486; 10880354; 10949026; 10996800; 11114542; 11717309; 12754297; 12944463; 15123689; 17535812; 20043968; 22103330; 23332762; 25640178 47 63 166 glucokinase activation, protection of islet survival +GYS1 GYS1 Carbohydrate Metabolism - starch and sucrose; EC 2.4.1.11; Transferase P13807 2997 19q13.33 human S723-p 4787599 SSSLSTPsEPLSPTS phosphorylation 34758018 1 4 0 primes phopshorylation at S641 +MARK2 MARK2 EC 2.7.11.1; EC 2.7.11.26; KINASE; Kinase, protein; Protein kinase, CAMK; Protein kinase, Ser/Thr (non-receptor) Q7KZI7 2011 11q13.1 human S409-p 3245780 NPKQRRFsDQAAGPA enzymatic activity, inhibited neural plasticity; cytoskeletal reorganization 25512381 1 29 3 1) PKAC inhibits phosphorylation of Tau caused by MARK-2. 2) PKAC acts as a negative regulator of MARK-2 in regulating microtubule stability and neurite outgrowth. +Lck Lck EC 2.7.10.2; KINASE; Kinase, protein; Oncoprotein; Protein kinase, TK; Protein kinase, tyrosine (non-receptor) P06240 16818 4 D2.2|4 63.26 cM mouse Y192-p 447821 NLDNGGFyISPRITF SH2 molecular association, regulation; enzymatic activity, inhibited; protein conformation; phosphorylation cell differentiation, inhibited; signaling pathway regulation CD45(DISRUPTS) 28735895; 35806279 5 29 1070 induces TCR signaling but inhibits ERK phosphorylation +WWOX WWOX Apoptosis; EC 1.1.1.-; Oxidoreductase; Tumor suppressor Q9NZC7 51741 16q23.1-q23.2 human Y287-p 457684 LSPTKNDyWAMLAYN protein degradation cell cycle regulation 16288044; 24899407 4 1 0 +UBA52-RPS27A-UBB-UBC ubiquitin Ubiquitin-like modifier P62991 mouse K11-ac 459088 FVKTLTGkTITLEVE ubiquitin protein degradation 33976225 3 3 0 forms an electrostatic interaction with D129, loss of K133 ubiquitylation or the K133:D129 salt bridge stabilizes IL-1B +EGR1 EGR1 C2H2-type zinc finger protein; DNA-binding; Transcription factor P18146 1958 5q31.2 human S104-p 11423700 YEHLTAEsFPDISLN transcription, altered DNA(DISRUPTS) 8662759 1 0 0 +WRN WRN Cell cycle regulation; DNA repair, damage; DNA-binding; EC 3.6.4.12; Helicase; Nucleolus Q14191 7486 8p12 human K887-ac 14512103 LTEIRNEkFRLYKLK RecQ_Zn_bind protein stabilization; ubiquitination 20428248 1 1 0 inhibits ubiquitination +RELA NFkB-p65 DNA-binding; Nuclear receptor co-regulator; Transcription factor Q04206 5970 11q13.1 human S45-p 25302163 CEGRSAGsIPGERST RHD_DNA_bind molecular association, regulation transcription, inhibited DNA(DISRUPTS) 27466442 1 6 2 +PTEN PTEN Carbohydrate Metabolism - inositol phosphate; EC 3.1.3.16; EC 3.1.3.48; EC 3.1.3.67; Motility/polarity/chemotaxis; Nuclear receptor co-regulator; PHOSPHATASE; Phosphatase, lipid; Tumor suppressor P60484 5728 10q23.31 human K327-ub 1881390900 LTKNDLDkANKDKAN protein degradation; phosphorylation 34785642 1 0 0 AKT S473 increased ; regulates the HCC cell chemoresistance (chemoresistant) +RPS6KB1 p70S6K iso2 EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, AGC; Protein kinase, Ser/Thr (non-receptor); Translation P23443-2 6198 17q23.1 human S371-p 448806 TRQTPVDsPDDSTLS Pkinase_C carcinogenesis, induced; cell motility, induced; cell growth, induced; apoptosis, inhibited; signaling pathway regulation 31974627 17 4 11 PI3K/Akt/mTOR signaling pathway +CHEK1 Chk1 EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, CAMK; Protein kinase, Ser/Thr (non-receptor); Tumor suppressor O14757 1111 11q24.2 human S296-p 447832 GFSKHIQsNLDFSPV activity, induced; molecular association, regulation; intracellular localization; enzymatic activity, induced cell cycle regulation; carcinogenesis, induced; transcription, induced; signaling pathway regulation; cell growth, induced; apoptosis, inhibited; transcription, inhibited; cell growth, altered 14-3-3 gamma(INDUCES); claspin(INDUCES); CDC25A(INDUCES) 15707391; 17976513; 20639859; 24240236; 26140595; 30573684; 31209037; 31597105; 32076484; 33414171; 33591599; 34508175; 34773074; 37023702 31 16 10 +ATF4 ATF-4 DNA-binding; Transcription factor P18848 468 22q13.1 human S224-p 1734100 NDSGICMsPESYLGS molecular association, regulation FBW1B(INDUCES) 18052253 1 0 0 +Tnnt2 TNNT2 Motility/polarity/chemotaxis; Motor P50752 21956 1 E4|1 59.32 cM mouse S288-p 457603 INDNQKVsKTRGKAK Troponin phosphorylation cytoskeletal reorganization 15774859 3 0 0 ROCK II induced desensitization to Ca++ and depression in maximal tension. +Pin1 PIN1 EC 5.2.1.8; Isomerase; Nuclear receptor co-regulator Q9QUR7 23988 9 A3|9 7.6 cM mouse S16-p 447772 PGWEKRMsRSSGRVY WW enzymatic activity, inhibited translation, altered 20215645 12 2 0 +CSRP1 CSRP1 Cytoskeletal; Motility/polarity/chemotaxis P21291 1465 1q32.1 human Y62-p 2091905 EIYCKSCyGKKYGPK LIM intracellular localization 12802285 1 0 0 +MUC1 MUC1 Actin-binding; Cell adhesion; Membrane protein, integral; Motility/polarity/chemotaxis; Nuclear receptor co-regulator; Tumor suppressor P15941 4582 1q22 human Y1229-p 448462 SSTDRSPyEKVSAGN molecular association, regulation GSK3B(DISRUPTS); CTNNB1(INDUCES) 11152665 5 10 447 +ULK2 ULK2 Autophagy; EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, Other; Protein kinase, Ser/Thr (non-receptor) Q8IYT8 9706 17p11.2 human S1027-p 41294001 CSIERRLsALCHSTA DUF3543 molecular association, regulation; intracellular localization autophagy, inhibited ATG101(DISRUPTS); RB1CC1(DISRUPTS) 26052940 1 0 0 nuclear localization +Rack1 RACK1 Adaptor/scaffold; G protein; G protein, heterotrimeric; G protein, heterotrimeric beta; Motility/polarity/chemotaxis; Nuclear receptor co-regulator P68040 14694 11|11 B1.2 mouse S110-p 31879014 GHTKDVLsVAFSSDN WD40 protein degradation; molecular association, regulation; ubiquitination UBE2T(INDUCES) 35265209 1 1 0 +RNF4 RNF4 EC 6.3.2.-; Ligase; Nuclear receptor co-regulator; Transcription factor; UBIQUITIN LIGASE; Ubiquitin conjugating system; Ubiquitin ligase P78317 6047 4p16.3 human T26-p 41192600 RTREATStPEISLEA enzymatic activity, induced 25948581 1 0 0 regulates homologous recombination repair during S-phase +Sox9 SOX9 DNA-binding; Transcription factor Q04887 20682 11 E2|11 77.27 cM mouse R178-me 10338211 DYKYQPRrRKSVKNG molecular association, regulation cell cycle regulation; cell growth, induced; transcription, induced CTNNB1(DISRUPTS) 19725955 1 0 0 promotes cyclin D1 expression, regulates endochondral ossification, chondrocyte/cartilage development during embryogenesis +PLD1 PLD1 EC 3.1.4.4; Lipid Metabolism - ether lipid; Lipid Metabolism - glycerophospholipid; Motility/polarity/chemotaxis; Phospholipase Q13393 5337 3q26.31 human S505-p 11091057 GSVKRVTsGPSLGSL enzymatic activity, induced 20231899 1 2 1 in response to glucose deprivation +CEACAM3 CEACAM3 Cell adhesion; Immunoglobulin superfamily; Membrane protein, integral P40198 1084 19q13.2 human Y230-p 478344 PRTAASIyEELLKHD molecular association, regulation endocytosis, induced PIK3C2A(INDUCES); VAV1(INDUCES) 17339478; 21216968; 35850306 3 0 1 important for bacterial uptake (N. gonorrhoeae) and killing of internalized pathogens; induces phagocytosis; Vav1 required for CEACAM3-mediated phagocytosis of bacterial pathogens; specific interaction between SH2 domain of VAV1 and ITAM-like sequence of CEACAM3 +Pak2 PAK2 EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, STE; Protein kinase, Ser/Thr (non-receptor) Q8CIN4 224105 16 B2|16 22.4 cM mouse S141-p 448295 TVKQKYLsFTPPEKD cell growth, induced 33539470 17 84 76 induces neurite outgrowth +ECPAS ECM29 Vesicle Q5VYK3 23392 9q31.3 human S1666-p 25296914 IPLIKKNsLESSGVR molecular association, regulation DYNC1I1(INDUCES) 26609957 1 1 1 increased retrograde transport of proteasomes in growing axons +Dlg4 PSD-95 Adaptor/scaffold P31016 29495 10q24 rat S295-p 456936 PTSPRRYsPVAKDLL PDZ_assoc activity, induced; protein stabilization; intracellular localization 17988632; 23864697 4 12 0 Dephosphorylation of S295 induce phosphorylation at site T19; enhances GluR surface expression and current potentiation +XRCC5 Ku80 DNA-binding; EC 3.6.1.-; EC 3.6.4.-; Helicase; Nuclear receptor co-regulator; Nucleolus; RNA-binding P13010 7520 2q35 human K36-ub 12407332 SPFEQAKkVITMFVQ Ku_N molecular association, regulation DNA repair, induced DNA(DISRUPTS) 27895153 1 2 1 +Nfatc2 NFAT1 DNA-binding; Transcription factor Q60591 18019 2 H3|2 88.91 cM mouse S276-p 447850 ASPQRSRsPSPQPSP transcription, inhibited 11030334 0 1 0 +FOXM1 FOXM1 DNA-binding; Transcription factor Q08050 2305 12p13.33 human S672-p 467914 QSAPPLEsPQRLLSS protein stabilization transcription, induced 22094256 1 3 0 +SHC1 SHC1 Adaptor/scaffold; Apoptosis; Mitochondrial; Motility/polarity/chemotaxis P29353 6464 1q21.3 human S213-p 58109401 TRRRKPCsRPLSSIL PID apoptosis, induced 27624939 1 1 0 +NR3C2 MCR DNA-binding; Nuclear receptor P08235 4306 4q31.23 human K399-sm 3144810 LNIVQYIkPEPDGAF transcription, induced; transcription, inhibited 14500761; 17105732 3 1 0 Ubc9 can be a transcriptional mineralocorticoid receptor coactivator. +HSPB1 HSP27 Chaperone; Heat shock protein; Motility/polarity/chemotaxis; SUMO LIGASE; SUMO ligase P04792 3315 7q11.23 human S78-p 448402 PAYSRALsRQLSSGV protein degradation; molecular association, regulation; phosphorylation; activity, induced; sumoylation; ubiquitination; intracellular localization; protein conformation cell cycle regulation; carcinogenesis, induced; apoptosis, altered; cell motility, induced; signaling pathway regulation; transcription, altered; autophagy, induced; cell differentiation, induced; cell growth, induced; apoptosis, inhibited; cytoskeletal reorganization; transcription, inhibited; cell growth, altered TRAF6(DISRUPTS); TPM1(INDUCES); p53(INDUCES); HSF1(DISRUPTS); hnRNP D0(DISRUPTS); HSP27(DISRUPTS) RNA(DISRUPTS) 11383510; 11912188; 12367505; 14749215; 15581903; 18477563; 18720982; 18950704; 19597476; 21245386; 34477462; 34498800; 34516752; 34851698; 35000271; 35499078; 36701233 40 25 30 induces lysophagy +Akt1 Akt1 EC 2.7.11.1; KINASE; Kinase, protein; Oncoprotein; Protein kinase, AGC; Protein kinase, Ser/Thr (non-receptor) P31750 11651 12 F1|12 61.2 cM mouse Y326-p 447858 EVLEDNDyGRAVDWW Pkinase enzymatic activity, induced apoptosis, altered 11445557; 20606012 3 2 26 +SQLE SQLE EC 1.14.13.132; Endoplasmic reticulum; Lipid Metabolism - steroid biosynthesis; Membrane protein, integral; Membrane protein, multi-pass; Oxidoreductase Q14534 6713 8q24.13 human S83-p 1877421600 IGFFWAKsPPESENK protein degradation; molecular association, regulation; ubiquitination carcinogenesis, inhibited; cell growth, inhibited; apoptosis, induced MARCH6(INDUCES) 35767703 1 0 0 +Tnp2 TP2 DNA-binding P11101 24840 10q11 rat K88-ac 10769110 NRKTLEGkVSKRKAV TP2 molecular association, regulation chromatin organization, altered NPM3(DISRUPTS) 19710011 2 3 0 +Cttn Cortactin Actin-binding; Cytoskeletal; Motility/polarity/chemotaxis NP_001385572 60465 1q41-q42 rat S135-p 31881968 QMDRVDQsAVGFEYQ HS1_rep molecular association, regulation cytoskeletal reorganization ACTB(DISRUPTS) 26033110 1 2 0 phospho-mimetic mutant shows atypical growth cone filopodia +Ano1 ANO1 Membrane protein, integral; Membrane protein, multi-pass; Transporter; Transporter, ion channel Q8BHY3 101772 7|7 F5 mouse S471-p 50773175 EKSLRKEsRNKETDK Anoctamin activity, induced 31461344 2 1 0 +Gata4 GATA4 Motility/polarity/chemotaxis; Transcription factor Q08369 14463 14 D1|14 33.24 cM mouse S160-p 31834900 GFAGSYSsPYPAYMA GATA-N transcription, induced CCND2(INDUCES) 24474767 1 0 0 +Stx7 STX7 Membrane protein, integral; Vesicle O70439 53331 10|10 A4 mouse S125-p 468880 FVARVRAsSRVSGGF molecular association, regulation STX8(INDUCES); VTI1B(INDUCES); VAMP8(INDUCES) 18710945 1 8 58 +LCP2 SLP76 Adaptor/scaffold Q13094 3937 5q35.1 human K30-ub 25786202 YFKKLNYkDCEKAVK SAM_2 ubiquitination 22902619 1 1 0 +Rims1 RIMS1 Adaptor/scaffold; Vesicle Q9JIR4 84556 9q13 rat S1045-p 4725312 PRAKRGRsAESLHMT neural plasticity 35443170 1 6 0 +TRAF3 TRAF3 UBIQUITIN LIGASE; Ubiquitin conjugating system; Ubiquitin ligase Q13114 7187 14q32.32 human T29-p 23154950 HTDRSAGtPVFVPEQ cell growth, induced; apoptosis, inhibited; transcription, induced; signaling pathway regulation 34255829 1 2 2 induces NIK stabilization and NF-kB signaling +PFKP PFKP Carbohydrate Metabolism - fructose and mannose; Carbohydrate Metabolism - galactose; Carbohydrate Metabolism - glycolysis and gluconeogenesis; Carbohydrate Metabolism - pentose phosphate pathway; EC 2.7.1.11; KINASE; Kinase, other Q01813 5214 10p15.2 human S386-p 483639 AVRLRGRsFAGNLNT molecular association, regulation; protein stabilization; ubiquitination; enzymatic activity, induced; phosphorylation carcinogenesis, induced; autophagy, induced; cell motility, induced; cell growth, induced; transcription, induced SYVN1(DISRUPTS); ATG4B(INDUCES) 33588886; 33607258; 36435833 3 44 190 +SKAP2 SKAP2 Adaptor/scaffold O75563 8935 7p15.2 human Y261-p 449668 QPIDDEIyEELPEEE cell motility, induced 26577701 5 8 100 macrophages migration towards cancer cells +DMD dystrophin Cytoskeletal; Motility/polarity/chemotaxis P11532 1756 Xp21.2-p21.1 human T3361-p 35542206 YPMVEYCtPTTSGED protein stabilization; molecular association, regulation cytoskeletal reorganization DAG1(INDUCES) 25082828 1 2 0 +ESPL1 separase EC 3.4.22.49; Protease Q14674 9700 12q13.13 human S1399-p 1211206 KVNFSDDsDLEDPVS enzymatic activity, inhibited CDK1(INDUCES) 17974570 1 13 0 phosphorylation of S1399 is a key residue in CDK1-dependent inhibition of separase +Nfe2l1 NFE2L1 DNA-binding; Transcription factor Q61985 18023 11 D|11 60.12 cM mouse S497-p 28700306 EGAVGYSsDSETLDL transcription, inhibited 23816881 1 0 0 +MVP MVP RNA-binding Q14764 9961 16p11.2 human S864-p 480371 PLGRRVAsGPSPGEG molecular association, regulation; activity, inhibited DNA repair, induced 14-3-3 epsilon(INDUCES) 23590642 1 2 67 14-3-3e negatively regulating the BLM resistance activity of MVP and induce DDR +EPAS1 HIF2A DNA-binding; Transcription factor Q99814 2034 2p21 human T406-p 1874020204 ELAQLAPtPGDAIIS protein stabilization 34285132 1 0 0 +Slc12a1 NKCC2 Membrane protein, integral; Membrane protein, multi-pass; Transporter; Transporter, SLC family P55014 20495 2 F1|2 61.23 cM mouse T96-p 458227 TNTYYLQtFGHNTMD AA_permease_N activity, induced 12732642; 24808538 15 2 0 +Mef2d MEF2D DNA-binding; Transcription factor Q63943 17261 3 F1|3 38.78 cM mouse S437-p 449407 SIKSEPVsPSRERSP apoptosis, induced 16407541 7 19 26 +N Nucleocapsid Protein P59595 1489678 SARSCoV1 K62-sm 1868657900 TALTQHGkEELRFPR CoV_nucleocap molecular association, regulation Nucleocapsid Protein(INDUCES) 15848177 1 0 0 sumoylation-mediated homo-oligomerization +CFL1 Cofilin-1 Cytoskeletal; Motility/polarity/chemotaxis; Nuclear receptor co-regulator P23528 1072 11q13.1 human S24-p 9218418 DMKVRKSsTPEEVKK Cofilin_ADF molecular association, regulation cytoskeletal reorganization 14-3-3 zeta(INDUCES) 22855535 1 8 9 inhibition of depolymerization of actin, cessation of degranulation +Nampt PBEF Cell cycle regulation; Cofactor and Vitamin Metabolism - nicotinate and nicotinamide; Cytokine; EC 2.4.2.12; Transferase Q99KQ4 59027 12|12 A3 mouse K53-ac 33351372 NSKVRKVkYEETVFY NAMPT_N enzymatic activity, inhibited 25921090 1 2 1 inhibits PBEF secretion +TERF2 TRF2 DNA repair, damage; DNA-binding Q15554 7014 16q22.1 human S365-p 452842 PTQALPAsPALKNKR molecular association, regulation; protein stabilization cell cycle regulation; cell growth, induced RTEL1(DISRUPTS) 27366950; 31723267 3 66 94 +Kcnb1 Kv2.1 Channel, cation; Channel, ligand-gated; Channel, potassium; Membrane protein, integral; Membrane protein, multi-pass Q03717 16500 2 H3|2 87.22 cM mouse S457-p 473558 MKDAFARsIEMMDIV activity, induced 24962901 4 6 0 +TFAP2A AP-2 alpha DNA-binding; Transcription factor P05549 7020 6p24.3 human K10-sm 580826098 WKLTDNIkYEDCEDR activity, induced transcription, induced 30926672 1 2 0 enhances transcription of HIF1A +CDC25A CDC25A EC 3.1.3.48; Motility/polarity/chemotaxis; PHOSPHATASE; Protein phosphatase, dual-specificity P30304 993 3p21.31 human S88-p 458298 DSGFCLDsPGPLDSK M-inducer_phosp protein degradation; molecular association, regulation; ubiquitination; phosphorylation cell cycle regulation; apoptosis, inhibited BTRC(INDUCES); FBW1B(INDUCES) 14603323; 15798217; 19734889; 28192398; 34156324; 34363019 7 2 0 +Vcl Vinculin Cell adhesion; Cytoskeletal; Motility/polarity/chemotaxis Q64727 22330 14 A3|14 11.53 cM mouse Y1065-p 454003 WVRKTPWyQ______ Vinculin activity, induced; molecular association, regulation; protein conformation cell adhesion, induced; cell motility, altered; cytoskeletal reorganization 20006947; 26240176 9 1 22 increases interaction with F-actin and talin +PAX6 PAX6 iso2 DNA-binding; Motility/polarity/chemotaxis; Transcription factor P26367-2 5080 11p13 human K89-sm 1877427000 PRAIGGSkPRVATPE PAX protein degradation 32826860 1 0 0 SENP1-mediated de-SUMOylation improves the stability of PAX6 and has protective effects of PAX6 on corneal endothelial injuries +ESR1 ER-alpha DNA-binding; Nuclear receptor; Transcription factor P03372 2099 6q25.1-q25.2 human K302-m1 3084639 PLMIKRSkKNSLALS protein stabilization transcription, induced 18471979 1 1 0 +BACE1 BACE EC 3.4.23.46; Membrane protein, integral; Protease P56817 23621 11q23.3 human K275-ac 478257 EINGQDLkMDCKEYN Asp protein stabilization; intracellular localization 17425515 1 1 0 regulates translocation through secretory pathway +PIN1 PIN1 EC 5.2.1.8; Isomerase; Nuclear receptor co-regulator Q13526 5300 19p13.2 human Y23-p 473849 SRSSGRVyYFNHITN WW molecular association, regulation cell cycle regulation KIF20B(INDUCES) 10037602; 11470801 2 1 3 regulates association to phosphopeptides; in vitro and in vivo +E2F1 E2F1 DNA-binding; Transcription factor Q01094 1869 20q11.22 human K161-ub 95155308 NWAAEVLkVQKRRIY E2F_TDP protein stabilization DNA repair, induced; cell growth, induced; transcription, induced DNA(INDUCES) 28542143 1 0 0 +EPS8 EPS8 Adaptor/scaffold Q12929 2059 12p12.3 human Y525-p 457963 NRHIDRNyEPLKTQP cell cycle regulation; cell motility, induced 32641864 3 20 399 +RACK1 RACK1 Adaptor/scaffold; G protein; G protein, heterotrimeric; G protein, heterotrimeric beta; Motility/polarity/chemotaxis; Nuclear receptor co-regulator P63244 10399 5q35.3 human Y52-p 464119 LTRDETNyGIPQRAL molecular association, regulation; protein conformation; phosphorylation cell motility, altered; cell adhesion, altered; signaling pathway regulation; cell growth, altered CaR(DISRUPTS); FAK(INDUCES) 19423701; 23652203 2 1 230 EGFR signaling for CAR activation +PVR PVR Immunoglobulin superfamily; Membrane protein, integral; Motility/polarity/chemotaxis; Receptor, misc. P15151 5817 19q13.31 human Y398-p 450742 SANGHVSySAVSREN molecular association, regulation 15194502 1 4 17 +PDCD5 PDCD5 Apoptosis O14737 9141 19q13.11 human K97-ub 12246096 QGLIEILkKVSQQTE dsDNA_bind protein degradation apoptosis, inhibited 25499082 1 3 9 +Gabbr2 GABBR2 GPCR, family 3; Membrane protein, integral; Membrane protein, multi-pass; Receptor, GPCR Q80T41 242425 4|4 B1 mouse S783-p 473060 VTSVNQAsTSRLEGL GBR2_CC protein degradation; receptor recycling, induced; intracellular localization; receptor internalization, inhibited signaling pathway regulation; endocytosis, inhibited 24094109; 32083308; 32111696; 33432190; 36311027 10 0 0 +GATA1 GATA1 DNA-binding; Transcription factor P15976 2623 Xp11.23 human S161-p 40407600 SSLPVPNsAYGGPDF molecular association, regulation carcinogenesis, induced; cell motility, induced HDAC3(INDUCES); HDAC4(INDUCES) 25726523 1 0 0 GATA1-HDAC3/4 complex induces EMT of breast cancer cells, inhibits E-cadherin and promotes fibronectin expression +CDC25A CDC25A EC 3.1.3.48; Motility/polarity/chemotaxis; PHOSPHATASE; Protein phosphatase, dual-specificity P30304 993 3p21.31 human K150-ac 56843600 NEAFEFKkPVRPVSR M-inducer_phosp protein stabilization cell cycle regulation 27462461 1 0 0 +BIRC5 Survivin Apoptosis O15392 332 17q25.3 human S20-p 485776 FLKDHRIsTFKNWPF BIR protein stabilization; molecular association, regulation; intracellular localization; phosphorylation cell cycle regulation; apoptosis, induced XIAP(DISRUPTS) 17612487; 20427271; 21148584; 24069188; 27332895 6 1 0 chromos ome alignment, segregation, and possibly cytokinesis; stimulates Aurora B activation and increases phosphorylation of CENPA S7; critical for accurate chromosome segregation +Cnbp ZNF9 DNA-binding; RNA-binding; Transcription factor P53996 12785 6|6 D1 mouse T177-p 25320968 RECTIEAtA______ molecular association, regulation; intracellular localization transcription, induced DNA(INDUCES) 34168080 1 2 1 regulates Type I IFN promoter activity +ATR ATR EC 2.7.11.1; KINASE; Kinase, protein; Membrane protein, integral; Protein kinase, Ser/Thr (non-receptor); Protein kinase, atypical Q13535 545 3q23 human T1589-p 22561303 FSMLDHLtQWARHKF cell cycle regulation; cell growth, induced 21908846 1 1 0 +GRB10 GRB10 Adaptor/scaffold Q13322 2887 7p12.1 human S150-p 454185 PELCGPGsPPVLTPG protein stabilization; activity, inhibited 15952796; 21659604 2 5 0 +JUP CTNNG Cytoskeletal; Motility/polarity/chemotaxis P14923 3728 17q21.2 human S665-p 2048381 PDYRKRVsVELTNSL cell adhesion, induced 32508670 2 35 0 causes ultrastructural alterations at ICD +KRT8 K8 Cytoskeletal P05787 3856 12q13.13 human K483-ac 474633 ESSDVLPk_______ cytoskeletal reorganization 18203277; 18983182 3 3 37 +Epb4.9 dematin iso2 Actin-binding; Motility/polarity/chemotaxis; Tumor suppressor Q9WV69-2 13829 14 D2|14 36.32 cM mouse S381-p 450255 NELKKKAsLF_____ VHP molecular association, regulation; protein conformation 27073223 5 0 0 headpiece domain of dematin-S381E strongly interacts with the core domain +IL2RB IL2RB Membrane protein, integral; Receptor, cytokine P14784 3560 22q12.3 human Y536-p 450934 LPLNTDAyLSLQELQ molecular association, regulation apoptosis, inhibited; cell growth, altered STAT5A(INDUCES); STAT5B(INDUCES); SHB(INDUCES) 10602027; 12200137 3 3 2 +Rps6ka1 p90RSK EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, AGC; Protein kinase, Ser/Thr (non-receptor); Translation P18653 20111 4|4 D2.3 mouse S369-p 447990 HQLFRGFsFVATGLM Pkinase_C enzymatic activity, induced 16103085 66 48 64 +Mecp2 MECP2 Transcription, coactivator/corepressor Q9Z2D6 17257 X A7.3|X 37.63 cM mouse T158-p 31879716 DPNDFDFtVTGRGSP MBD sumoylation; phosphorylation transcription, induced 31974426 2 0 0 decrease GSK3 beta phosphoryation; inhibition of locomotor activity; Bdnf mRNA expression level increased +Mef2d MEF2D DNA-binding; Transcription factor Q63943 17261 3 F1|3 38.78 cM mouse S180-p 449933 LTDPRLLsPQQPALQ activity, induced 10849446 3 44 11 +FANCD2 FANCD2 DNA repair, damage Q9BXW9 2177 3p25.3 human S331-p 11315004 KSKGRASsSGNQESS FancD2 molecular association, regulation; ubiquitination BRCA2(INDUCES) 19861535 1 1 0 confers resistance to mitomycin C +FSCN1 fascin Actin-binding; Cytoskeletal; Motility/polarity/chemotaxis Q16658 6624 7p22.1 human K41-ub 8101911 NASASSLkKKQIWTL Fascin cytoskeletal reorganization 27879315 1 2 5 fascin bundling activity +Pink1 PINK1 EC 2.7.11.1; KINASE; Kinase, protein; Membrane protein, integral; Mitochondrial; Protein kinase, Other; Protein kinase, Ser/Thr (non-receptor) Q99MQ3 68943 4|4 D3 mouse S411-p 1883601200 VERGGNGsLMAPEVS Pkinase phosphorylation 36469690 1 1 0 inhibits phosphorylation of UBA52 +Bad BAD Apoptosis Q61337 12015 19|19 A mouse T201-p 450485 NLGKGGStPSQ____ Bcl-2_BAD activity, induced; molecular association, regulation apoptosis, inhibited Bcl-xL(DISRUPTS) 14967141; 18469002 3 0 0 +Yap1 YAP1 Oncoprotein; Transcription, coactivator/corepressor P46938 22601 9|9 A1 mouse S112-p 448847 PQHVRAHsSPASLQL protein degradation; molecular association, regulation; intracellular localization; activity, inhibited cell differentiation, inhibited; apoptosis, altered; carcinogenesis, altered; carcinogenesis, inhibited; apoptosis, induced; cell motility, induced; cell growth, inhibited; cell adhesion, induced; cell motility, inhibited; signaling pathway regulation; transcription, altered; cell differentiation, altered; cell differentiation, induced; cell growth, induced; transcription, inhibited 14-3-3 beta(INDUCES); 14-3-3 epsilon(INDUCES); CTNNA1(INDUCES) 11118213; 19289085; 21376238; 23644383; 26109051; 26657153; 26757814; 33046882; 33686240; 34108620; 34133792; 34531315; 34608264; 34615998; 34874744; 35358489; 35394840; 35413847; 35619099; 35696363; 35697803; 35798842; 36374802; 36640330 207 33 180 +Xbp1 XBP1 iso2 DNA-binding; Transcription factor O35426-2 22433 mouse K297-ac 1879877103 PEFIVSVkKEPLEDD protein degradation apoptosis, induced 31541078 1 1 0 K257 and 297 mediates hepatic steatosis, apoptosis, and insulin resistance +Nefm NFM Cytoskeletal P08553 18040 14|14 D1 mouse S645-p 451040 KKEVTKEsPKEEKVE cytoskeletal reorganization 19193875 1 6 0 slightly altered axoplasmic organization in 7S/A mice mutant +SNW1 Skip Nuclear receptor co-regulator; Spliceosome; Transcription, coactivator/corepressor Q13573 22938 14q24.3 human Y292-p 464278 AKLAEALyIADRKAR SKIP_SNW molecular association, regulation transcription, induced SMAD3(INDUCES) 28666867 1 5 65 enhances TGF-beta-induced Smad3 transcriptional activitation +PSMA5 PSMA5 EC 3.4.25.1; Protease; Proteasome complex P28066 5686 1p13.3 human S16-p 483589 DRGVNTFsPEGRLFQ Proteasome_A_N molecular association, regulation; phosphorylation cell cycle regulation; cell growth, induced; signaling pathway regulation PKN2(INDUCES); RP1(INDUCES); AMPD2(INDUCES); CLCC1(INDUCES); PLK1(INDUCES) 34831298 1 44 2 inhibits CDK1 phosphorylation and regulates phospho-a5/PLK1/CDK1 signaling +Bcar1 P130Cas Adaptor/scaffold; Motility/polarity/chemotaxis Q61140 12927 8|8 E1 mouse Y414-p 448720 SVVDDGVyAVPPPAE carcinogenesis, induced; cell motility, induced; cell motility, altered; cytoskeletal reorganization 20430882; 36375119 18 23 126 +Lyn LYN EC 2.7.10.2; KINASE; Kinase, protein; Oncoprotein; Protein kinase, TK; Protein kinase, tyrosine (non-receptor) P25911 17096 4 A1|4 2.05 cM mouse Y508-p 447624 YTATEGQyQQQP___ molecular association, regulation; intracellular localization; enzymatic activity, inhibited endocytosis, induced; cell growth, inhibited; signaling pathway regulation Bcr(INDUCES) 10415030; 16920712; 21636860; 21964606; 35500650 27 48 1560 induces JNK signaling +Sstr3 SSTR3 GPCR, family 1; Membrane protein, integral; Membrane protein, multi-pass; Receptor, GPCR P30936 171044 7q34 rat S351-p 456710 VRSQEPGsGPPEKTE receptor desensitization, altered; receptor internalization, altered 9295322 1 1 0 +Cilk1 ICK EC 2.7.11.22; KINASE; Kinase, protein; Protein kinase, CMGC; Protein kinase, Ser/Thr (non-receptor) Q9JKV2 56542 9|9 E1 mouse T157-p 456051 IRSRPPYtDYVSTRW Pkinase enzymatic activity, induced 15988018 3 21 86 +MDC1 MDC1 Cell cycle regulation Q14676 9656 6p21.33 human S299-p 477757 SQPPGEDsDTDVDDD molecular association, regulation cell cycle regulation NBS1(INDUCES) 18678890 1 26 17 MDC1-NBS1 interaction regulates intra-S-phase checkpoint activation +Sp7 osterix C2H2-type zinc finger protein; DNA-binding; Transcription factor Q8VI67 170574 15|15 F3 mouse S77-p 15334101 GLLSPAGsPPAPASG activity, induced; protein degradation; molecular association, regulation; ubiquitination cell differentiation, inhibited; transcription, altered FBXW7(INDUCES); p300(INDUCES); SMARCA4(INDUCES) 20682789; 32931083 4 0 0 +LCP2 SLP76 Adaptor/scaffold Q13094 3937 5q35.1 human Y145-p 448220 PVEDDADyEPPPSND molecular association, regulation; phosphorylation exocytosis, induced; cytoskeletal reorganization; transcription, induced NCK1(INDUCES); VAV1(INDUCES) 11046020; 12817019; 17148460; 21725281; 22534133; 33931484 21 1 0 +PMAIP1 NOXA Apoptosis; Mitochondrial Q13794 5366 18q21.32 human S13-p 17790900 ARKNAQPsPARAPAE PMAIP1 molecular association, regulation apoptosis, altered; carcinogenesis, altered; apoptosis, inhibited; cell growth, altered MCL1(DISRUPTS) 21145489; 26411306 3 3 0 +GSK3B GSK3B EC 2.7.11.1; EC 2.7.11.26; KINASE; Kinase, protein; Protein kinase, CMGC; Protein kinase, Ser/Thr (non-receptor) P49841 2932 3q13.33 human S9-p 449111 SGRPRTTsFAESCKP protein degradation; protein stabilization; molecular association, regulation; enzymatic activity, inhibited; activity, inhibited; phosphorylation; ubiquitination; intracellular localization; enzymatic activity, altered cell cycle regulation; carcinogenesis, induced; apoptosis, altered; cell motility, induced; apoptosis, induced; signaling pathway regulation; cell growth, induced; cell motility, altered; transcription, inhibited; cell growth, altered; carcinogenesis, inhibited; cell growth, inhibited; transcription, induced; transcription, altered; autophagy, induced; cell differentiation, induced; apoptosis, inhibited; cytoskeletal reorganization; cell adhesion, altered CRMP-2(DISRUPTS) 11035810; 11389054; 11520785; 11579131; 11877389; 11956225; 12167628; 12522140; 12900420; 12917346; 15033922; 15878878; 15950778; 16039586; 16115820; 16155008; 16397900; 16484495; 18451303; 18757413; 18794113; 19179806; 20352103; 20637111; 21308747; 21422248; 21530327; 21868755; 21893193; 21996745; 22385658; 24879152; 30154149; 32382110; 33184107; 33388549; 33661942; 33829789; 33890983; 33967735; 34101073; 34237099; 34287648; 34326276; 34433641; 34484860; 34639123; 34966427; 34975828; 35090098; 35090553; 35347072; 35347116; 35564180; 35565964; 35698879; 35739087; 35853487; 35884549; 35986274; 36520954; 36575468; 36635496; 36648507; 36869126; 37400529; 37495110; 37500620; 7980435 570 46 227 +PDCD1 PD-1 Apoptosis; Membrane protein, integral Q15116 5133 2q37.3 human K233-ub 1877141202 LDFQWREkTPEPPVP protein degradation 33109719 3 0 0 +BHLHE40 BHLHB2 Nucleolus; Transcription regulation O14503 8553 3p26.1 human K159-sm 31089509 EVLQYLAkHENTRDL Hairy_orange protein stabilization; intracellular localization transcription, inhibited 21829689; 27626674 2 1 0 +KAT7 MYST2 ACETYLTRANSFERASE; Acetyltransferase; EC 2.3.1.48; Nuclear receptor co-regulator; Transcription, coactivator/corepressor O95251 11143 17q21.33 human S50-p 460900 TRSSARLsQSSQDSS protein degradation; molecular association, regulation; ubiquitination cell cycle regulation; cell growth, inhibited DDB2(INDUCES) 26572825 1 23 84 +MEF2C MEF2C DNA-binding; Transcription factor Q06413 4208 5q14.3 human K116-ac 12674411 HSPESEDkYRKINED HJURP_C molecular association, regulation cell differentiation, induced; transcription, induced MRF(INDUCES) DNA(INDUCES) 15831463 1 0 0 +Irf6 IRF6 DNA-binding; Transcription factor P97431 54139 1 H6|1 97.6 cM mouse S424-p 27451041 GSVRLQIsTPDIKDN activity, induced; phosphorylation cell differentiation, induced; transcription, induced 31578523 3 9 0 +NUSAP1 NUSAP1 Cell cycle regulation; Nucleolus Q9BXS6 51203 15q15.1 human T300-p 7989914 HKRSLTKtPARKSAH NUSAP molecular association, regulation; intracellular localization cytoskeletal reorganization 22101338 1 1 3 inhibits NUSAP binding to microtubules in mitosis +CDC73 CDC73 Cell cycle regulation; Tumor suppressor Q6P1J9 79577 1q31.2 human K247-ub 12302328 STGKNFSkNIFAILQ CDC73_N protein degradation; ubiquitination 35551175 1 5 28 +Arrdc3 ARRDC3 Unknown function Q7TPQ9 105171 13|13 C2 mouse Y382-p 462206 LQGPLFAyIQEFRFL molecular association, regulation INSR(INDUCES) 32156724 1 3 9 +POLH POLH DNA repair, damage; EC 2.7.7.7; Transferase Q9Y253 5429 6p21.1 human K474-sm 1877365913 GPAVTATkKATTSLE intracellular localization; enzymatic activity, inhibited 32350109 1 1 0 +ATXN3 ataxin-3 iso1 DEUBIQUITINASE; DNA repair, damage; EC 3.4.19.12; Protease; Transcription regulation; Ubiquitin-specific protease P54252-1 4287 14q32.12 human S236-p 9441003 LQRALALsRQEIDME UIM activity, induced; intracellular localization transcription, altered 19542537 1 2 0 +Rps6kb1 p70S6K EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, AGC; Protein kinase, Ser/Thr (non-receptor); Translation P67999 83840 10q26 rat S434-p 448356 SFEPKIRsPRRFIGS phosphorylation; enzymatic activity, induced cytoskeletal reorganization 17220300; 25903132 28 1 0 dendritic spine morphogenesis; required for p70S6K T412 phosphorylation which leads to enzymatic activation +Crebbp CBP ACETYLTRANSFERASE; Acetyltransferase; DNA-binding; EC 2.3.1.48; Motility/polarity/chemotaxis; Nuclear receptor co-regulator; Transcription, coactivator/corepressor P45481 12914 16 A1|16 2.4 cM mouse K1057-sm 3726904 EEKKPEVkVEAKEEE molecular association, regulation transcription, inhibited DAXX(INDUCES); HDAC2(INDUCES) 16287980 1 1 0 +BLM BLM DNA repair, damage; DNA replication; EC 3.6.4.12; Helicase P54132 641 15q26.1 human K344-sm 2293705 TSKDLLSkPEKMSMQ BLM_N intracellular localization 31171703 2 1 0 localization to PML bodies determined by the ratio of SUMO and SIM in telomere clustering scaffolds +Ffar4 GPR120 GPCR, family 1; Lipid-binding; Membrane protein, integral; Membrane protein, multi-pass; Receptor, GPCR Q7TMA4 107221 19|19 C2 mouse S361-p 54179700 NDLSVISs_______ receptor internalization, induced; molecular association, regulation ARR3(INDUCES) 26873857 1 0 0 +Prkd1 PRKD1 Autophagy; EC 2.7.11.13; KINASE; Kinase, protein; Motility/polarity/chemotaxis; Protein kinase, CAMK; Protein kinase, Ser/Thr (non-receptor) Q62101 18760 12|12 B3 mouse S916-p 447632 KALSERVsIL_____ molecular association, regulation; protein conformation; enzymatic activity, induced cell motility, altered; cytoskeletal reorganization ITGB1(INDUCES) 10473617; 10867018; 17485491; 24643961 43 13 0 +CLDN11 Claudin-11 Cell adhesion; Membrane protein, integral; Membrane protein, multi-pass O75508 5010 3q26.2 human Y191-p 478785 AFGENRFyYTAGSSS molecular association, regulation cell motility, altered Src(INDUCES) 30664792 1 3 76 +TEX14 TEX14 Cancer Testis Antigen (CTA); KINASE; Kinase, protein; Protein kinase, Other; Protein kinase, Ser/Thr (non-receptor) Q8IWB6 56155 17q22 human T618-p 25158902 EEASSPStGQPSLCS molecular association, regulation; intracellular localization PLK1(INDUCES) 22405274 1 0 0 +PAK1 PAK1 EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, STE; Protein kinase, Ser/Thr (non-receptor) Q13153 5058 11q13.5-q14.1 human K11-ub 56714903 NGLDIQDkPPAPPMR protein degradation 27302166 1 0 0 +VGLL4 VGLL4 iso4 Transcription, coactivator/corepressor Q14135-4 9686 3p25.3-p25.2 human S155-p 3195941 ASRPAGLsPTLTPGE VGLL4 cell cycle regulation; cell growth, induced 28739871 1 21 3 Mitotic phosphorylation +KIF14 KIF14 Microtubule-binding; Motor Q15058 9928 1q32.1 human S1217-p 114810405 PIKNLHSsHSSGLMD intracellular localization 28630147 1 0 0 spindle localization of Kif14 in anaphase +Ikzf1 Ikaros C2H2-type zinc finger protein; DNA-binding; Transcription factor Q03267 22778 11 A1|11 7.02 cM mouse S195-p 451356 TGHLRTHsVGKPHKC intracellular localization 12464629 1 1 0 +Irs1 IRS1 Adaptor/scaffold; Motility/polarity/chemotaxis P35569 16367 1 C5|1 42.0 cM mouse S1097-p 453434 GCRRRHSsETFSAPT activity, inhibited 15364919 13 39 122 +Camk4 CAMK4 EC 2.7.11.17; KINASE; Kinase, protein; Protein kinase, CAMK; Protein kinase, Ser/Thr (non-receptor) P08414 12326 18 B1|18 18.15 cM mouse T196-p 448164 EHQVLMKtVCGTPGY Pkinase transcription, induced; signaling pathway regulation 20952540 11 7 8 CAMK/CREB signaling pathway regulates transcription, activity of sympathetic neurons, and bone mass accrual. +L1CAM NCAM-L1 Cell adhesion; Membrane protein, integral Q90933 396059 chicken Y1186-p 456529 KDETFGEyRSLESEA Bravo_FIGEY intracellular localization 16087710 12 3 10 Alanine mutation directs protein to apical part of MDCK cells; phosphorylation functions in the sort of protein to basolateral surface. +CMKLR1 CMKLR1 GPCR, family 1; Membrane protein, integral; Membrane protein, multi-pass; Receptor, GPCR Q99788 1240 12q23.3 human Y316-p 32668901 SCMNPILyVFMGQDF 7tm_1; TM receptor internalization, induced 24658352 1 0 0 +RPS6KA4 MSK2 EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, AGC; Protein kinase, Ser/Thr (non-receptor) O75676 8986 11q13.1 human S347-p 447952 PVYSPPGsPPPGDPR Pkinase_C enzymatic activity, induced 10806207 1 39 4 +PAK3 PAK3 EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, STE; Protein kinase, Ser/Thr (non-receptor) O75914 5063 Xq23 human S154-p 448123 VNNQKYMsFTSGDKS carcinogenesis, induced; cell adhesion, induced; apoptosis, inhibited; cytoskeletal reorganization; signaling pathway regulation 17077177; 36319849 5 5 0 Mutation of any of the 4 serines/threonines to alanine reduced the AILIM/ICOS-induced elongation ratio in activated T cells. Three sites are believed to be autophosphorylation sites, and one is believed to be an Akt1 site. Treatment with Akt inhibitor shows a reduction in this elongation ratio.; induces the MAPK pathway +PDGFRB PDGFRB EC 2.7.10.1; KINASE; Kinase, protein; Membrane protein, integral; Oncoprotein; Protein kinase, TK; Protein kinase, tyrosine (receptor) P09619 5159 5q32 human Y579-p 447521 VSSDGHEyIYVDPMQ molecular association, regulation; phosphorylation; enzymatic activity, induced cell growth, altered RASA1(INDUCES); PLCG1(INDUCES); SHC1(INDUCES); PIK3R1(INDUCES) 10642538; 10683371; 8195171; 9454734; 9642269 11 1 0 +Bcl2l11 BIM Apoptosis O88498 64547 3q36 rat S65-p 449330 GPLAPPAsPGPFATR activity, induced; protein degradation; molecular association, regulation apoptosis, induced PIN1(INDUCES) 14681225; 15470142; 15728578; 16504941; 16818494 23 1 1 +Sirt7 SIRT7 DEACETYLASE; Deacetylase; EC 3.5.1.-; Nucleolus Q8BKJ9 209011 11|11 E2 mouse T264-p 1874512900 EAASKADtILCLGSS SIR2 protein stabilization; molecular association, regulation; ubiquitination; phosphorylation carcinogenesis, inhibited; cell motility, inhibited; transcription, inhibited; signaling pathway regulation UBR5(DISRUPTS); SKP2(INDUCES) 34433808 1 0 0 inhibits ubiquitination of itself, inhibits AKT phosphorylation and PI3K/AKT pathway; primes phosphorylation at T256 and S260 +YAP1 YAP1 Oncoprotein; Transcription, coactivator/corepressor P46937 10413 11q22.1 human K342-me 1880718704 PSTANSPkCQELALR activity, induced; intracellular localization transcription, induced 34795238 2 1 0 c-Met transcription +CYLD CYLD DEUBIQUITINASE; EC 3.4.19.12; Protease; Tumor suppressor; Ubiquitin conjugating system; Ubiquitin-specific protease Q9NQC7 1540 16q12.1 human K530-ub 573787426 YFTCALKkALFVKLK CAP_GLY protein degradation signaling pathway regulation 31366726 1 2 0 enhances NF-kB signaling. +Foxo4 FOXO4 DNA-binding; Oncoprotein; Transcription factor Q9WVH3 54601 X D|X 43.89 cM mouse K408-ac 459044 GGMPSSSkLGTGVSL transcription, inhibited 16012755 2 0 0 +Lima1 eplin Actin-binding; Cytoskeletal; Motility/polarity/chemotaxis Q9ERG0 65970 15 F1|15 56.13 cM mouse S360-p 455424 PMHPKPLsPDARTSS molecular association, regulation; intracellular localization cell motility, induced; cytoskeletal reorganization ACTB(DISRUPTS) 17875928 3 69 83 destabilization of stress fibres, membrane ruffle formation +RABEP1 RABEP1 Vesicle Q15276 9135 17p13.2 human S407-p 468548 DGLRRAQsTDSLGTS Rabaptin receptor recycling, induced cell motility, induced Rab4(INDUCES) 22975325 1 60 614 invasion into Matrigel; persistent directional migration; EGFR and integrin recycling + IGM P0DOX6 human K292-ub 1877089300 DQVQAEAkESGPTTY C1-set intracellular localization 32127472 1 1 0 localization in endoplasmic reticulum (ER) lumin +RPL13A RPL13A Ribosomal; Translation P40429 23521 19q13.33 human S77-p 5594501 PYHFRAPsRIFWRTV Ribosomal_L13 activity, induced; protein degradation; molecular association, regulation; ubiquitination translation, altered; translation, inhibited GAPDH(INDUCES) 18995835; 22771119 3 2 1 essential for GAIT-mediated translational silencing of inflammatory genes; Phosphorylation is required for RPLl3A release from ribosome. GAPDH binds to phosphorylated S77 and prevents degradation. +Trio TRIO Apoptosis; EC 2.7.11.1; GEF; GEF, misc.; KINASE; Kinase, protein; Protein kinase, CAMK; Protein kinase, Ser/Thr (non-receptor) NP_001101128 310192 2q22 rat Y2685-p 27425000 LLNPNYIyDVPPEFV activity, induced; molecular association, regulation cell growth, induced; cytoskeletal reorganization; signaling pathway regulation DCC(INDUCES) 23230270 1 0 0 netrin-1/DCC pathway; Rac1 activation induced; regulates DCC surface expression in the growth cone of cortical neurons; cortical axon extension +Foxc2 FOXC2 Apoptosis; Cell development/differentiation; DNA-binding; Transcription factor Q61850 14234 8 E1|8 70.33 cM mouse S124-p 36950200 NSIRHNLsLNECFVK Forkhead intracellular localization cell motility, inhibited; signaling pathway regulation 25486430 1 0 0 promotes cytoplasmic localization, CK2 signaling pathway regulation, decreased cell migration +AKAP13 AKAP13 Adaptor/scaffold; GEF; GEF, Rac/Rho; Nuclear export; Nuclear receptor co-regulator; Oncoprotein Q12802 11214 15q25.3 human T2467-p 487261 SLPRRAEtFGGFDSH molecular association, regulation 14-3-3 sigma(INDUCES) 36402225 1 24 299 +Foxo4 FOXO4 DNA-binding; Oncoprotein; Transcription factor Q9WVH3 54601 X D|X 43.89 cM mouse T32-p 455572 QSRPRSCtWPLPRPD molecular association, regulation transcription, altered 14-3-3 zeta(INDUCES) 14690436 6 8 34 +FGFR1 FGFR1 EC 2.7.10.1; KINASE; Kinase, protein; Membrane protein, integral; Oncoprotein; Protein kinase, TK; Protein kinase, tyrosine (receptor) P11362 2260 8p11.23 human Y766-p 447922 ALTSNQEyLDLSMPL molecular association, regulation; phosphorylation carcinogenesis, induced; cell growth, induced GPR89A(INDUCES); GRB2(INDUCES); ECSIT(INDUCES); PLCG1(INDUCES); GAB1(INDUCES); SHP-2(INDUCES); USP15(INDUCES) 1656221; 35574218 10 1 0 regulates phosphorylation of downstream proteins +CBLB Cbl-b Adaptor/scaffold; Calcium-binding; EC 6.3.2.-; Ligase; UBIQUITIN LIGASE; Ubiquitin conjugating system; Ubiquitin ligase Q13191 868 3q13.11 human Y133-p 50346901 KEGKERMyEEQSQDR Cbl_N ubiquitination; enzymatic activity, induced 26416283 1 0 0 +ARHGAP19 ARHGAP19 GAP; GAP, Rac/Rho Q14CB8 84986 10q24.1 human S422-p 3196670 QKRARSRsFSGLIKR molecular association, regulation 29420299 1 18 17 binding protects from dephosphorylation of the T404 and T476 residues; binding to 14-3-3 proteins +CAV1 caveolin-1 Adaptor/scaffold; Motility/polarity/chemotaxis; Nuclear receptor co-regulator P33724 403980 dog S80-p 448421 AEPEGTHsFDGIWKA Caveolin intracellular localization 11078729 3 0 0 phosphorylation of this site regulates secretion of caveolin-1 in the pancreatic acinar cells AR42J +Ffar4 GPR120 GPCR, family 1; Lipid-binding; Membrane protein, integral; Membrane protein, multi-pass; Receptor, GPCR Q7TMA4 107221 19|19 C2 mouse S350-p 31014808 GAIFTDTsVRRNDLS receptor internalization, induced; molecular association, regulation ARR3(INDUCES) 26873857; 32817367 5 1 0 +F11R JAM-A Cell adhesion; Membrane protein, integral Q9Y624 50848 1q23.3 human S284-p 467829 KVIYSQPsARSEGEF intracellular localization 11027562 5 51 19 +PARD3 PAR3-alpha Adaptor/scaffold; Motility/polarity/chemotaxis Q8TEW0 56288 10p11.22-p11.21 human Y1127-p 457508 GHMMDALyAQVKKPR molecular association, regulation cytoskeletal reorganization LIMK2(DISRUPTS) 17053785 2 25 175 +Wnk4 WNK4 EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, Other; Protein kinase, Ser/Thr (non-receptor) Q80UE6 69847 11|11 D mouse K223-ub 40323305 SEEVEMLkGLQHPNI Pkinase protein degradation 23576762 1 1 0 regulates electrolyte homeostasis and involved in Pseudohypoaldosteronism type II (PHAII) pathogenesis +Irs1 IRS1 Adaptor/scaffold; Motility/polarity/chemotaxis P35569 16367 1 C5|1 42.0 cM mouse Y608-p 447555 NLHTDDGyMPMSPGV neural plasticity 32075735 33 12 294 +YWHAB 14-3-3 beta Adaptor/scaffold P31946 7529 20q13.12 human K77-ac 31068005 KTERNEKkQQMGKEY 14-3-3 molecular association, regulation SYNPO(DISRUPTS) 23840712 1 0 0 +SMG9 SMG9 RNA processing Q9H0W8 56006 19q13.31 human Y41-p 10887902 PGGRERDyIAPWERE molecular association, regulation cytoskeletal reorganization IQGAP1(DISRUPTS) 21640080 1 2 67 +G3BP1 G3BP-1 Adaptor/scaffold; EC 3.6.4.12; EC 3.6.4.13; Helicase; RNA-binding Q13283 10146 5q33.1 human Y40-p 1877717200 FYGKNSSyVHGGLDS NTF2 molecular association, regulation G3BP-1(INDUCES) 35798143 1 0 0 +PFKM PFKM Carbohydrate Metabolism - fructose and mannose; Carbohydrate Metabolism - galactose; Carbohydrate Metabolism - glycolysis and gluconeogenesis; Carbohydrate Metabolism - pentose phosphate pathway; EC 2.7.1.11; Kinase, other P08237 5213 12q13.11 human S74-p 55569803 EATWESVsMMLQLGG PFK enzymatic activity, inhibited 27153534 1 1 0 +DAP3 DAP3 Apoptosis; Mitochondrial; Nuclear receptor co-regulator P51398 7818 1q22 human S215-p 2226204 YVWNKREsTEKGSPL DAP3 apoptosis, induced 18227431 1 1 0 +NOS3 eNOS Amino Acid Metabolism - arginine and proline; EC 1.14.13.39; Oxidoreductase P29474 4846 7q36.1 human S633-p 448637 WRRKRKEsSNTDSAG Flavodoxin_1 molecular association, regulation; enzymatic activity, induced signaling pathway regulation JNK1(DISRUPTS); ERK2(DISRUPTS); P38A(DISRUPTS) 23768697; 26598507; 35182051 28 12 7 PI3K-Akt-eNOS signaling pathway +ADRA1D ADRA1D GPCR, family 1; Membrane protein, integral; Membrane protein, multi-pass; Receptor, GPCR P25100 146 20p13 human T328-p 1424270005 MRSAKGHtFRSSLSV 7tm_1 receptor internalization, altered signaling pathway regulation 29551601 1 1 0 regulates ERK signaling pathway, induces calcium signaling de-sensitization +RAD52 RAD52 DNA repair, damage P43351 5893 12p13.33 human K406-ac 971232911 GNWESHRkSQDMKKR molecular association, regulation; intracellular localization DNA repair, induced RFA2(INDUCES); RPA3(INDUCES); RAD51(INDUCES); RPA1(INDUCES) 29590107 1 1 0 accumulation of RAD52 at DSB sites +Nrip1 RIP140 Nuclear receptor co-regulator; Transcription, coactivator/corepressor Q8CBD1 268903 16|16 C3.1 mouse K529-ac 459039 DIHSDGTkFSPQNYT NRIP1_repr_2 intracellular localization transcription, inhibited 15879431 0 2 0 +BRF1 GTF3B Transcription initiation complex Q92994 2972 14q32.33 human T270-p 22996307 RLTEFEDtPTSQLTI TFIIB molecular association, regulation cell cycle regulation; transcription, inhibited POLR3A(DISRUPTS) 22281053 1 0 0 +DCBLD2 DCBLD2 Cell adhesion; Membrane protein, integral Q96PD2 131566 3q12.1|3 human Y677-p 475112 LPITGPEyATPIIMD molecular association, regulation CRKL(INDUCES) 23770091 2 2 3 +RUNX1 AML1 DNA-binding; Oncoprotein; Transcription factor Q01196 861 21q22.12 human R206-me 2363103 SELEQLRrTAMRVSP molecular association, regulation cell differentiation, altered; transcription, induced SIN3A(DISRUPTS) DNA(DISRUPTS) 18316480 2 1 0 +Irgm1 IRGM EC 3.6.5.-; Endoplasmic reticulum; Hydrolase Q60766 15944 11|11 B1.2 mouse K275-ub 27194819 YEKIVGDkVAVWKQR IIGP protein degradation 35197566 1 2 0 +NADK2 NADK2 EC 2.7.1.23 Q4G0N4 133686 5p13.2 human K76-ac 25541818 SRVVVVAkTTRYEFE NAD_kinase enzymatic activity, induced 35868311 1 2 0 K76Q and K304Q mutants reduced proline production, K76Q and K304Q mutants and S116A showed reduced catalytic activity, phosphorylation, succinylation, or acetylation could generate a charge repulsion in the active site +Ulk1 ULK1 Autophagy; EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, Other; Protein kinase, Ser/Thr (non-receptor) O70405 22241 5|5 F mouse S913-p 10428808 KVAELLSsGLQTAID DUF3543 cell cycle regulation; autophagy, induced 34778891 1 2 0 +HRAS HRas G protein; G protein, monomeric; G protein, monomeric, Ras; Motility/polarity/chemotaxis; Oncoprotein P01112 3265 11p15.5 human T148-p 23113995 YIETSAKtRQGVEDA Ras protein degradation; molecular association, regulation; ubiquitination; phosphorylation carcinogenesis, inhibited; cell growth, inhibited; transcription, inhibited; signaling pathway regulation CTNNB1(DISRUPTS); BTRC(INDUCES) 22494971; 30413483 2 1 1 ERK phosphorylation, ERK pathway activation +NLRP3 NLRP3 Inhibitor Q96P20 114548 1q44 human T659-p 1871776517 KIEINLStRMDHMVS activity, induced; molecular association, regulation NEK7(INDUCES) 33432150 1 1 0 increased pro-IL-1? maturation; induce inflammasome activation +ESR1 ER-alpha DNA-binding; Nuclear receptor; Transcription factor P03372 2099 6q25.1-q25.2 human K266-ac 461005 RRGGRMLkHKRQRDD activity, induced; protein stabilization; molecular association, regulation cell growth, inhibited; cell motility, inhibited; transcription, induced; transcription, altered DNA(INDUCES) 16497729; 19887647; 24101509; 33544437 4 2 0 MOF depletion promotes proliferation, motility and invasion in HCC +NFATC1 NFAT2 DNA-binding; Transcription factor O95644 4772 18q23 human S161-p 56629001 TATLSLPsLEAYRDP cell growth, induced DNA(INDUCES) 27346349 2 1 0 +CCP110 CP110 Cell cycle regulation O43303 9738 16p12.3 human S366-p 9314148 GSYAKLPsPEPSMSP intracellular localization cell cycle regulation 12361598 1 17 3 +SLC4A4 SLC4A4 Membrane protein, integral; Membrane protein, multi-pass; Transporter; Transporter, SLC family Q9Y6R1 8671 4q13.3 human S232-p 4699755 ADIGKTVsSASRMFT Band_3_cyto protein conformation; activity, inhibited 30377224 1 9 5 +CAMK2A CAMK2A iso2 EC 2.7.11.17; KINASE; Kinase, protein; Protein kinase, CAMK; Protein kinase, Ser/Thr (non-receptor) Q9UQM7-2 815 5q32 human T306-p 449596 LKGAILTtMLATRNF molecular association, regulation; intracellular localization; enzymatic activity, inhibited; phosphorylation NMDAR2B(DISRUPTS) 28636948 18 10 2 inhibits phosphorylation at T286, regulates LTP, fear memory, spatial learning +Disc1 DISC1 Cell development/differentiation; Motility/polarity/chemotaxis Q811T9 244667 8 E2|8 73.26 cM mouse S710-p 18942700 QLQEAGSsPHAEDEE molecular association, regulation; intracellular localization cell motility, induced; signaling pathway regulation BBS1(INDUCES); BBS4(INDUCES); GSK3B(DISRUPTS) 21471969 1 2 0 +CDKN1B p27Kip1 Cell cycle regulation; Inhibitor; Oncoprotein; Protein kinase, regulatory subunit P46527 1027 12p13.1 human T198-p 448781 PGLRRRQt_______ protein degradation; protein stabilization; molecular association, regulation; ubiquitination; intracellular localization cell cycle regulation; carcinogenesis, inhibited; apoptosis, induced; cell motility, induced; transcription, induced; cell growth, altered 14-3-3 sigma(INDUCES); STMN1(INDUCES); 14-3-3 epsilon(INDUCES); CDK2(DISRUPTS); CDK4(INDUCES); 14-3-3 eta(INDUCES); JAK2(INDUCES); 14-3-3 theta(INDUCES) 12042314; 14504289; 15280662; 15743786; 17053782; 17237771; 18570873; 18593906; 19672859; 21423803; 23707388; 25684140; 26307683; 27197201; 33755959; 35108359 27 0 6 +DNMT3A DNMT3A Amino Acid Metabolism - cysteine and methionine; EC 2.1.1.37; METHYLTRANSFERASE; Methyltransferase; Methyltransferase, DNA Q9Y6K1 1788 2p23.3 human S390-p 17548178 LFPVCHDsDESDTAK methylation; intracellular localization; enzymatic activity, inhibited 25066127 1 6 0 decreases methylation of CpG +CHEK2 Chk2 EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, CAMK; Protein kinase, Ser/Thr (non-receptor); Tumor suppressor O96017 11200 22q12.1 human S456-p 981404 PEVWAEVsEKALDLV Pkinase protein degradation; ubiquitination apoptosis, induced 17715138 1 1 0 reduction in apoptotic response to DNA damage +DVL2 DVL2 Adaptor/scaffold; Motility/polarity/chemotaxis O14641 1856 17p13.1 human K484-ub 21173392 KYASGLLkAGLIRHT DEP molecular association, regulation; intracellular localization cell motility, induced; signaling pathway regulation Cofilin-1(INDUCES); VANGL1(INDUCES) 31340145 1 6 0 DVL2 variant with all encoded lysine residues mutated to arginine is sufficient to restore WNT activation +TRIM65 TRIM65 Ubiquitin conjugating system Q6PJ69 201292 17q25.1 human T413-p 1868914503 RCRLGPHtDNIGRGP SPRY carcinogenesis, inhibited; signaling pathway regulation 31332286 1 1 0 dephosphorylated form (6A mutant) contributes to TRIM65 function in tumor progression +DYRK1A DYRK1A EC 2.7.12.2; KINASE; Kinase, protein; Protein kinase, CMGC; Protein kinase, dual-specificity (non-receptor) Q13627 1859 21q22.13 human S529-p 475065 SNSGRARsDPTHQHR molecular association, regulation; enzymatic activity, induced 14-3-3 beta(INDUCES) 17229891 2 6 0 14-3-3 binding increases catalytic activity of DYRK1A. +SUMO3 SUMO3 Ubiquitin-like modifier P55854 6612 21q22.3 human K11-sm 2407412 EKPKEGVkTENDHIN protein processing signaling pathway regulation 12506199 3 8 0 decreases amyloidogenesis and increases nonamyloidogenic APP processing +ACTB ACTB Cytoskeletal; Motility/polarity/chemotaxis P60709 60 7p22.1 human K84-m1 31094539 TNWDDMEkIWHHTFY Actin molecular association, regulation cell cycle regulation; cytoskeletal reorganization; cell motility, inhibited MYH10(DISRUPTS) 23673617 1 1 0 +NFKBIB IkB-beta Inhibitor Q15653 4793 19q13.2 human S19-p 447917 DADEWCDsGLGSLGP protein degradation 8657102 6 0 0 +H2BC3 H2B DNA-binding P33778 3018 6p22.2 human K116-ac 480280 HAVSEGTkAVTKYTS molecular association, regulation polybromo 1(INDUCES) 20368734 1 5 8 varying site specificity binding for each bromodomain 1-6 +Epha3 EphA3 EC 2.7.10.1; KINASE; Kinase, protein; Membrane protein, integral; Protein kinase, TK; Protein kinase, tyrosine (receptor) P29319 13837 16|16 C1.3 mouse Y602-p 449913 TYVDPHTyEDPTQAV EphA2_TM carcinogenesis, altered; cell motility, altered 20697431 3 6 31 +ETV1 ETV1 DNA-binding; Oncoprotein; Transcription factor P50549 2115 7p21.2 human S191-p 3059602 HRFRRQLsEPCNSFP ETS_PEA3_N activity, induced transcription, induced 12213813 3 0 3 +FANCG FANCG DNA repair, damage O15287 2189 9p13.3 human S387-p 454240 PRFSPPPsPPGPCMP activity, induced 15367677 2 0 0 +HNF4A HNF4 alpha DNA-binding; Nuclear receptor; Transcription factor P41235 3172 20q13.12 human K127-ac 460634 CFRAGMKkEAVQNER zf-C4 molecular association, regulation; intracellular localization; protein conformation transcription, induced Exportin-1(DISRUPTS); CBP(INDUCES) DNA(INDUCES) 10882110 1 0 0 +SHC4 SHC4 Adaptor/scaffold Q6S5L8 399694 15q21.1 human Y403-p 474333 QATEQMAyCPIQCEK molecular association, regulation SHP-2(INDUCES) 28213521 2 1 1 +Pak2 PAK2 EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, STE; Protein kinase, Ser/Thr (non-receptor) Q64303 29432 11q22 rat T402-p 448300 PEQSKRStMVGTPYW Pkinase molecular association, regulation cytoskeletal reorganization N-WASP(INDUCES) 28972183 15 2 11 +RET Ret EC 2.7.10.1; KINASE; Kinase, protein; Membrane protein, integral; Oncoprotein; Protein kinase, TK; Protein kinase, tyrosine (receptor) P07949 5979 10q11.21 human Y687-p 449892 AQAFPVSySSSGARR molecular association, regulation; protein conformation; enzymatic activity, induced cell growth, altered SHP-2(INDUCES) 20682772; 28009299 4 4 27 +Erbb3 HER3 EC 2.7.10.1; KINASE; Kinase, protein; Membrane protein, integral; Oncoprotein; Protein kinase, TK; Protein kinase, tyrosine (receptor) Q62799 29496 7q11 rat Y1219-p 448639 GSLEELGyEYMDVGS molecular association, regulation; phosphorylation PIK3CB(INDUCES); PIK3R1(INDUCES) 11546794 5 0 1 induces phosphorylation of Akt1. +TNFRSF1A TNF-R1 Membrane protein, integral; Receptor, cytokine P19438 7132 12p13.31 human T417-p 11077252 RTPRREAtLELLGRV Death molecular association, regulation; phosphorylation apoptosis, induced; signaling pathway regulation GRB2(DISRUPTS) 32159413 1 1 3 decrease ERK, Akt and STAT3 phosphorylation; non-canonical TNF-alpha signaling, necrosis induced +PRKDC DNAPK DNA repair, damage; EC 2.7.11.1; KINASE; Kinase, protein; Nucleolus; Protein kinase, Ser/Thr (non-receptor); Protein kinase, atypical P78527 5591 8q11.21 human T2671-p 3193652 TDPLVDHtSPSSDSL DNAPKcs_CC5 DNA repair, inhibited 24687855 1 4 0 cell survival inhibited +Prkcd PKCD EC 2.7.11.13; KINASE; Kinase, protein; Nuclear receptor co-regulator; Protein kinase, AGC; Protein kinase, Ser/Thr (non-receptor); Protein kinase, tyrosine (non-receptor); Tumor suppressor P09215 170538 16p16 rat Y332-p 450077 IPDNNGTyGKIWEGS molecular association, regulation; enzymatic activity, induced apoptosis, induced SHC1(INDUCES) 12024011; 14715667; 17956904; 18550549 13 25 532 +Ppp1r12a MYPT1 Motility/polarity/chemotaxis; PHOSPHATASE; Protein phosphatase, regulatory subunit Q10728 116670 7q21 rat T855-p 452075 PREKRRStGVSFWTQ intracellular localization; activity, inhibited 19095646 44 2 17 +AR AR DNA-binding; Nuclear receptor; Transcription factor P10275 367 Xq12 human S258-p 449806 VEALEHLsPGEQLRG Androgen_recep transcription, altered 15684382 3 2 1 +VIM Vimentin Cytoskeletal; Motility/polarity/chemotaxis P08670 7431 10p13 human S10-p 455451 TRSVSSSsYRRMFGG Filament_head cell motility, altered 19291697 4 11 1 +TP53 p53 Activator; DNA-binding; Motility/polarity/chemotaxis; Nuclear receptor co-regulator; Transcription factor; Tumor suppressor P04637 7157 17p13.1 human S149-gl 5148303 PVQLWVDsTPPPGTR P53 protein stabilization; ubiquitination; phosphorylation 16964247 1 1 0 decreases p53 T155 phosphorylation; decreases p53 ubiquitination +GAB1 GAB1 Adaptor/scaffold; Motility/polarity/chemotaxis Q13480 2549 4q31.21 human Y447-p 449791 SEELDENyVPMNPNS molecular association, regulation SHP-2(INDUCES); PIK3R1(INDUCES) 10978177; 9658397 6 2 12 +Epg5 EPG5 Q80TA9 100502841 mouse K252-ub 27195508 PEVTPFTkEQLKLLE molecular association, regulation autophagy, induced LC3A(DISRUPTS) 30931944 1 3 0 +ESR1 ER-alpha DNA-binding; Nuclear receptor; Transcription factor P03372 2099 6q25.1-q25.2 human S212-p 12127402 CKAFFKRsIQGHNDY zf-C4 transcription, induced 22266331; 34157297 8 1 0 +H3C1 H3 DNA-binding P68431 8350 6p22.2 human K37-ac 3612525 PATGGVKkPHRYRPG Histone molecular association, regulation chromatin organization, altered DNA(DISRUPTS) 20720004 2 1 0 +WASF3 WASF3 Actin-binding; Motility/polarity/chemotaxis Q9UPY6 10810 13q12.13 human Y337-p 486450 LPAQIIEyYNPSGPP cell motility, induced; cytoskeletal reorganization 17623672 1 0 0 induces lamellipodia formation +PINK1 PINK1 EC 2.7.11.1; KINASE; Kinase, protein; Membrane protein, integral; Mitochondrial; Protein kinase, Other; Protein kinase, Ser/Thr (non-receptor) Q9BXM7 65018 1p36.12 human T257-p 25544600 AGEYGAVtYRKSKRG intracellular localization autophagy, induced; apoptosis, inhibited 23953109; 34706234 3 3 0 induces mitophagy; induces localization of PARK2 +Foxp3 FOXP3 C2H2-type zinc finger protein; Cell cycle regulation; DNA-binding; Transcription factor Q99JB6 20371 X A1.1|X 3.41 cM mouse T175-p 29672100 CTFPRSGtPRKDSNL protein degradation cell growth, induced; transcription, altered 23853094 1 1 0 alanine mutants of S19 or T175 inhibited (lL2) or induced (CD25) transcription of FOXP3 responsive genes, suppressed T cell proliferation, and showed an anti-inflamatory effect in a murine colitis model +RPTOR Raptor Adaptor/scaffold Q8N122 57521 17q25.3 human S791-p 1868515108 IDKMRRAsSYSSLNS activity, inhibited carcinogenesis, induced; cell growth, induced 32312749; 34673774 2 0 0 inhibits mTORC1 activity; mTORC1 activity inhibited +TBX3 TBX3 DNA-binding; Transcription factor O15119 6926 12q24.21 human S719-p 23151362 AEKEAATsELQSIQR protein stabilization; intracellular localization cell motility, induced; transcription, inhibited 25595898 1 0 1 TBX3 S719E promotes transcriptional repression of E-cadherin +FOXO3 FOXO3A Autophagy; DNA-binding; Oncoprotein; Transcription factor O43524 2309 6q21 human K271-ac 460595 RGRAAKKkAALQTAP intracellular localization apoptosis, induced 25981116 3 0 0 inhibits nuclear localization +Mcl1 MCL1 Apoptosis; Channel, misc.; Inhibitor; Membrane protein, integral; Mitochondrial P97287 17210 3 F2.1|3 40.74 cM mouse S102-p 1172400 SAAAAIVsPEEELDG protein degradation; molecular association, regulation PIN1(DISRUPTS) 17670986 7 4 0 +Tp53 p53 Activator; DNA-binding; Motility/polarity/chemotaxis; Nuclear receptor co-regulator; Transcription factor; Tumor suppressor P02340 22059 11 B3|11 42.83 cM mouse T21-p 447541 ELPLSQEtFSGLWKL P53_TAD activity, induced; protein stabilization; molecular association, regulation; intracellular localization cell cycle regulation; apoptosis, altered; transcription, altered MDM2(DISRUPTS); p300(INDUCES) 14555661; 16704422; 20818388 35 0 0 +Stip1 STI1 Chaperone Q60864 20867 19|19 A mouse S189-p 465575 LLGVDLGsMDEEEEA intracellular localization 14754904 2 0 0 +Lpp LPP Adaptor/scaffold; Cytoskeletal; Motility/polarity/chemotaxis Q8BFW7 210126 16|16 B1 mouse Y403-p 3414611 HLTKKMLyDMENPPA cell cycle regulation; cell motility, altered 18515860 0 2 7 +AKT1S1 PRAS40 Apoptosis Q96B36 84335 19q13.33 human S203-p 454572 KRTEARSsDEENGPP PRAS molecular association, regulation cell growth, induced; autophagy, inhibited 14-3-3 beta(INDUCES); Raptor(DISRUPTS) 26876154 2 50 119 activates mTORC1 +MSH3 MSH3 DNA repair, damage P20585 4437 5q14.1 human K99-ac 9925427 ENDGPVKkKVKKVQQ intracellular localization 32900932 1 0 1 +HOXA11 HOXA11 DNA-binding; Transcription factor P31270 3207 7p15.2 human S98-p 55571505 RDCLQAPsAAGVPGD DUF3528 molecular association, regulation transcription, induced CBP(INDUCES) 27239043 1 1 0 +CAV2 caveolin-2 Adaptor/scaffold; Motility/polarity/chemotaxis P51636 858 7q31.2 human Y19-p 450198 LFMDDDSySHHSGLE Caveolin molecular association, regulation; intracellular localization; phosphorylation cell growth, induced; cell adhesion, induced; transcription, inhibited; signaling pathway regulation RASA1(INDUCES); ERK1(INDUCES); caveolin-1(INDUCES) 12091389; 15504032; 20455999; 22819829; 29371975 10 10 28 +Adam17 TACE EC 3.4.24.86; Membrane protein, integral; Motility/polarity/chemotaxis; Protease Q9Z0F8 11491 12 A1.3|12 8.3 cM mouse T735-p 449804 KPFPAPQtPGRLQAL activity, induced; molecular association, regulation; intracellular localization; enzymatic activity, induced carcinogenesis, induced; signaling pathway regulation FAK(INDUCES) 15923650; 29361535; 32197276; 32241917 18 15 6 induces sheddase activity; cell surface localization, TGFB1 upregulation ; induces Prss14/Epithin ectodomain shedding; T735A mutation induced altered localization of TACE. Wild-type TACE colocalized with calregulin an ER marker. T735E colocalizes with components of the protein secretory pathway. ; Astagaloside-III-dependent EGFR-pathway activation +SQSTM1 SQSTM1 Autophagy; Nuclear receptor co-regulator; Ubiquitin conjugating system Q13501 8878 5q35.3 human K189-ub 12312680 SRWLRKVkHGHFGWP autophagy, induced 27880896 1 3 11 antibacterial autophagy +MAP2K6 MKK6 EC 2.7.12.2; KINASE; Kinase, protein; Protein kinase, STE; Protein kinase, dual-specificity (non-receptor) P52564 5608 17q24.3 human S207-ac 4325701 ISGYLVDsVAKTIDA Pkinase enzymatic activity, inhibited; phosphorylation 16728640 2 0 0 yopJ inhibits MKK6 phosphorylation and its enzymatic activation in vitro +FADD FADD Adaptor/scaffold; Apoptosis Q13158 8772 11q13.3 human S203-p 22496704 MSWNSDAsTSEAS__ phosphorylation apoptosis, induced 21978935 1 1 0 enhances S194 phosphorylation; apoptosis and necrosis +GUCY1B1 GUCY1B1 EC 4.6.1.2; Guanylyl cyclase; Lyase; Nucleotide Metabolism - purine; Receptor, misc. Q02153 2983 4q32.1 human Y192-p 469612 ESKEEDFyEDLDRFE molecular association, regulation Src(INDUCES); Fyn(INDUCES) 16079134 3 0 0 +BOD1 BOD1 Q96IK1 91272 5q35.2 human T95-p 384464301 KVDNFVStHLDKQEW COMPASS-Shg1 cell cycle regulation 29142109 1 0 0 +Hdac1 HDAC1 DEACETYLASE; Deacetylase; EC 3.5.1.98; Hydrolase; Nuclear receptor co-regulator Q4QQW4 297893 5q36 rat K476-sm 2407422 KPEAKGVkEEVKMA_ molecular association, regulation neural plasticity; apoptosis, inhibited CREB iso1(DISRUPTS) 28186506 3 3 0 sumoylation rescues synaptic and memory deficits, and reduces amyloid plaque and apoptosis in APP/PS1 mice; Sumoylation increases CREB binding to DNA and mediates A? induction of Mcl-1 expression +Ptk2 FAK EC 2.7.10.2; KINASE; Kinase, protein; Protein kinase, TK; Protein kinase, tyrosine (non-receptor) O35346 25614 7q34 rat S722-p 447962 PSRPGYPsPRSSEGF molecular association, regulation; intracellular localization 12732587; 16373587 9 18 0 +POLH POLH DNA repair, damage; EC 2.7.7.7; Transferase Q9Y253 5429 6p21.1 human K682-sm 1877365920 SAVSHQGkRNPKSPL enzymatic activity, inhibited 32350109 1 1 0 +Nfatc4 NFAT3 DNA-binding; Transcription factor Q8K120 73181 14|14 C3 mouse S676-p 455348 SNGRRKRsPTQSFKF RHD_dimer activity, induced; intracellular localization transcription, altered 18086672 2 0 0 +TRPC6 TRPC6 Channel, cation; Membrane protein, integral; Membrane protein, multi-pass Q9Y210 7225 11q22.1 human S322-p 3363401 KNDYKKLsMQCKDFV activity, inhibited 19961855 5 0 0 suppresses TRPC6 channel current, G-alpha agonist-induced NFAT activation and myocyte hypertrophic responses +RASA1 RASA1 GAP; GAP, Ras; Motility/polarity/chemotaxis; Oncoprotein P09851 282032 cow Y457-p 449959 AVDGKEIyNTIRRKT molecular association, regulation DOK1(INDUCES) 7503985 3 6 38 +PXN PXN Adaptor/scaffold; Cell adhesion; Cytoskeletal; Motility/polarity/chemotaxis P49024 395832 chicken S188-p 471382 HYVIPESsSSAGGKA Paxillin protein stabilization cell motility, altered 17121676 2 1 0 promotes cell spreading by increasing the dynamics of membrane protrusions +SLC12A1 NKCC2 Membrane protein, integral; Membrane protein, multi-pass; Transporter; Transporter, SLC family P55015 100328575 rabbit T117-p 459122 KIEYYRNtGSVSGPK AA_permease_N activity, induced 16077079 4 2 0 +Mapk1 ERK2 EC 2.7.11.24; KINASE; Kinase, protein; Protein kinase, CMGC; Protein kinase, Ser/Thr (non-receptor) P63086 116590 11q23 rat Y185-p 447594 HTGFLTEyVATRWYR Pkinase activity, induced; molecular association, regulation; intracellular localization; enzymatic activity, induced cytoskeletal reorganization; signaling pathway regulation; cell growth, altered MEK1(INDUCES) 10473611; 10567369; 11731096; 12163549; 14627993; 16368189; 19427337; 19943942; 20096547; 21357465; 21660950; 21738764; 21917714 1163 158 4003 quercetin and myricetin-induced cardioprtection signaling; regulate cell proliferation in dentate gyrus following ischemia; Arginine methyltransferase 5 induced signaling for cell proliferation and differentiation; focal adhesion inhibition/dissociation; integrin Rac1-NADPH oxidase signaling +SLC12A6 KCC3 Membrane protein, integral; Membrane protein, multi-pass; Transporter; Transporter, SLC family Q9UHW9 9990 15q14 human T1048-p 4770548 YQEKVHMtWTKDKYM SLC12 activity, inhibited 19665974; 24043619; 27782176 6 10 0 acute cell swelling; Regulates the cotransporter activity +NR2F6 EAR-2 DNA-binding; Nuclear receptor P10588 2063 19p13.11 human S83-p 25802106 CKSFFKRsIRRNLSY zf-C4 transcription, induced DNA(DISRUPTS) 18701084 1 0 0 +NOTCH1 Notch 1 Membrane protein, integral; Motility/polarity/chemotaxis; Oncoprotein; Receptor, misc.; Transcription factor P46531 4851 9q34.3 human K2157-ac 18899504 KPGVQGKkVRKPSSK intracellular localization cell growth, induced; apoptosis, inhibited 28377411 2 1 0 +Phb1 PHB Apoptosis; Cell cycle regulation; Chaperone; Mitochondrial; Motility/polarity/chemotaxis; Nuclear receptor co-regulator; Oncoprotein; Transcription, coactivator/corepressor P67778 18673 11 59.01 cM|11 D mouse Y114-p 6374001 YTSIGEDyDERVLPS Band_7 molecular association, regulation; intracellular localization; phosphorylation; enzymatic activity, induced transcription, induced; signaling pathway regulation FCER1G(INDUCES) 24023254; 35219912 6 1 0 FCER1G and Syk-mediated signaling, increases antigen-induced mast cell degranulation; induces STAT6 phosphorylation, regulates ERK and STAT6 signaling, induces arginase activity +LRRFIP2 LRRFIP2 Unknown function Q9Y608 9209 3p22.2 human S202-p 20573501 SGLLRSAsLASLYNG activity, induced; molecular association, regulation signaling pathway regulation MYD88(INDUCES) 21220426 1 1 0 Increase NF-kB activity and regulates TLR4 signaling +UBAP2L NICE-4 RNA-binding; Ubiquitin conjugating system Q14157 9898 1q21.3 human S454-p 452474 AAPPPPSsPLPSKST cell growth, induced; autophagy, inhibited 37062825 2 48 2 +Des desmin Cytoskeletal; Motility/polarity/chemotaxis P31001 13346 1 C4|1 38.85 cM mouse S6-p 478272 __MSQAYsSSQRVSS transcription, altered; cell growth, altered 17381546 1 0 1 important for cardiomyogenesis +Oprm1 MOR-1 GPCR, family 1; Membrane protein, integral; Membrane protein, multi-pass; Receptor, GPCR P42866 18390 10 A1|10 1.85 cM mouse T370-p 447785 SARIRQNtREHPSTA receptor internalization, induced; receptor desensitization, induced; molecular association, regulation; receptor recycling, induced endocytosis, induced; signaling pathway regulation ARRB2(INDUCES) 21449911; 22725608; 25801029; 30018083; 32234959 19 5 0 regulates B-arrestin signaling +IRS1 IRS1 Adaptor/scaffold; Motility/polarity/chemotaxis P35568 3667 2q36.3 human S323-p 451399 MVGGKPGsFRVRASS phosphorylation 16611834 12 17 3 S323A has increased DOG-uptake and increased IRS-1 pTyr in +insulin. +MYD88 MYD88 Adaptor/scaffold Q99836 4615 3p22.2 human Y257-p 474538 KRLIPIKyKAMKKEF TIR molecular association, regulation signaling pathway regulation JAK2(INDUCES) 36172386 4 0 0 induces JAK2-STAT3 signaling +SREBF1 SREBP-1 iso3 DNA-binding; Membrane protein, integral; Membrane protein, multi-pass; Transcription factor P36956-3 6720 17p11.2 human S410-p 6729302 PPPSDAGsPFQSSPL protein degradation; activity, inhibited 19126544 1 0 0 +Pard3 PAR3-alpha Adaptor/scaffold; Motility/polarity/chemotaxis Q99NH2 93742 8 E2|8 74.66 cM mouse S885-p 455653 LGLKKSSsLESLQTA protein degradation 29464029 4 1 0 +KCNJ12 KCNJ12 Membrane protein, integral; Membrane protein, multi-pass Q14500 3768 17p11.2 human T354-p 3053611 KTYEVPStPRCSAKD IRK_C activity, inhibited 12234954 1 0 4 +Src Src EC 2.7.10.2; KINASE; Kinase, protein; Oncoprotein; Protein kinase, TK; Protein kinase, tyrosine (non-receptor) P05480 20779 2 H1|2 78.35 cM mouse Y133-p 2261000 LSTGQTGyIPSNYVA SH3_1 cell cycle regulation; cell growth, altered 8663329 2 0 0 +Dyrk1a DYRK1A EC 2.7.12.2; KINASE; Kinase, protein; Protein kinase, CMGC; Protein kinase, dual-specificity (non-receptor) Q61214 13548 16 C4|16 55.3 cM mouse Y145-p 449566 DGYDDDNyDYIVKNG intracellular localization cell cycle regulation; cell differentiation, altered 21878370 1 30 877 +MYC Myc DNA-binding; Nucleolus; Oncoprotein; Transcription factor P01106 4609 8q24.21 human K404-sm 40724409 PELENNEkAPKVVIL HLH protein degradation; ubiquitination transcription, inhibited 25895136 1 2 0 +HNRNPU hnRNP U DNA-binding; Nuclear receptor co-regulator; RNA splicing; RNA-binding; Spliceosome Q00839 3192 1q44 human S26-p 476219 ELKKRRLsDKGLKAE SAP molecular association, regulation; intracellular localization cell cycle regulation; chromatin organization, altered DNA(DISRUPTS) 33053167 1 16 61 +Oprm1 MOR-1 GPCR, family 1; Membrane protein, integral; Membrane protein, multi-pass; Receptor, GPCR P42866 18390 10 A1|10 1.85 cM mouse S375-p 447784 QNTREHPsTANTVDR receptor internalization, induced; receptor desensitization, induced; molecular association, regulation; phosphorylation endocytosis, induced; signaling pathway regulation ARRB2(INDUCES) 21449911; 21868358; 22725608; 23239825; 24629717; 30018083; 32234959 24 5 0 regulates B-arrestin signaling +TARBP2 TRBP Motility/polarity/chemotaxis; RNA processing; RNA-binding; Translation Q15633 6895 12q13.13 human S286-p 56757901 LRSCSLGsLGALGPA molecular association, regulation transcription, induced P70S6KB(DISRUPTS) 27407113 1 1 0 miRNA expression +ADRA1B ADRA1B GPCR, family 1; Membrane protein, integral; Membrane protein, multi-pass; Receptor, GPCR P18841 101843941 hamster S400-p 451003 GSLERSQsRKDSLDD receptor desensitization, altered 9353340 1 0 1 +LARP7 LARP7 RNA-binding Q4G0J3 51574 4q25 human T440-p 1869962000 ANREECRtQEKVNAT protein degradation; molecular association, regulation; ubiquitination cell cycle regulation; carcinogenesis, induced; DNA repair, induced BARD1(INDUCES) 32726637 1 0 0 +LTB4R LTB4R GPCR, family 1; Membrane protein, integral; Membrane protein, multi-pass; Receptor, GPCR Q15722 1241 14q12 human S320-p 4700741 SSTRRGGsLGQTARS phosphorylation signaling pathway regulation 30131369 1 5 0 phosphorylation of LTB4R basal phosphorylation site; chemotaxis, B-hexisaminidase release, regulates LTB4R function +CACNA1C CACNA1C Channel, calcium; Membrane protein, integral; Membrane protein, multi-pass Q13936 775 12p13.33 human S1981-p 455278 ASLGRRAsFHLECLK activity, induced 22100296; 22310722; 31759979 31 3 0 Ca-v1.2 channel activity induced +ADRA1B ADRA1B GPCR, family 1; Membrane protein, integral; Membrane protein, multi-pass; Receptor, GPCR P18841 101843941 hamster S394-p 451002 RPWTRGGsLERSQSR receptor desensitization, altered 9353340 1 0 0 +ESR1 ER-alpha DNA-binding; Nuclear receptor; Transcription factor P03372 2099 6q25.1-q25.2 human T311-p 449929 NSLALSLtADQMVSA activity, induced; molecular association, regulation; intracellular localization transcription, altered SRC-2(NOT_REPORTED); SRC-1(NOT_REPORTED); EGFR(DISRUPTS) 12138194; 23216744; 26079946 7 0 0 +Trp53 p53 iso2 Activator; DNA-binding; Motility/polarity/chemotaxis; Nuclear receptor co-regulator; Transcription factor; Tumor suppressor Q80ZA1 22059 11 B3|11 42.83 cM mouse K375-sm 1869726221 RAFQALIkEESPNC_ protein stabilization; intracellular localization apoptosis, induced; transcription, induced 23696846 1 0 0 +BCAR1 P130Cas Adaptor/scaffold; Motility/polarity/chemotaxis P56945 9564 16q23.1 human Y128-p 448778 SKAQQGLyQVPGPSP phosphorylation carcinogenesis, induced; cell motility, induced; cell growth, induced; cell adhesion, altered 22710723; 27447856 4 27 797 pY88 paxillin activates p130cas-PI3K-AKT signaling axis. +PKN2 PKN2 EC 2.7.11.13; KINASE; Kinase, protein; Protein kinase, AGC; Protein kinase, Ser/Thr (non-receptor) Q16513 5586 1p22.2 human T814-p 3253564 GMGYGDRtSTFCGTP Pkinase enzymatic activity, induced 19723632 1 4 73 +HOXB9 HOXB9 DNA-binding P17482 3219 17q21.32 human K27-ac 58948902 SEDAPPAkFPSGQYA Hox9_act carcinogenesis, inhibited; cell growth, inhibited; cell motility, inhibited; transcription, inhibited 27613418 1 1 0 +TP63 p63 DNA-binding; Transcription factor Q9H3D4 8626 3q28 human S477-p 7643500 NSMNKLPsVSQLINP protein degradation 19282665 1 0 0 DLX3-mediated degradation +Irf8 IRF8 DNA-binding; Transcription factor P23611 15900 8 E1|8 70.05 cM mouse Y107-p 2299204 QLDISEPyKVYRIVP IRF molecular association, regulation transcription, induced IRF8(INDUCES); PU.1(INDUCES); IRF2(INDUCES) 17200120 2 0 0 +Stat5b STAT5B DNA-binding; Oncoprotein; Transcription factor P52632 25126 10q31 rat Y679-p 449034 DRPKDEVySKYYTPV intracellular localization transcription, altered 12621061 1 0 0 +FEZ1 FEZ1 Q99689 9638 11q24.2 human S58-p 454522 SEIISFKsMEDLVNE FEZ molecular association, regulation; intracellular localization; protein conformation transcription, induced KIF5B(INDUCES); HSC70(DISRUPTS) 27247180; 28930676; 35172151 3 7 0 unphosphorylated FEZ1 is aggregated and colocalizes with Reelin; regulates localization of DNAPK; required for FEZ1 to promote HIV-1 uncoating and infection +KIT Kit EC 2.7.10.1; KINASE; Kinase, protein; Membrane protein, integral; Oncoprotein; Protein kinase, TK; Protein kinase, tyrosine (receptor) P10721 3815 4q12 human S741-p 450035 TKADKRRsVRIGSYI PK_Tyr_Ser-Thr enzymatic activity, inhibited; phosphorylation 7539802 1 0 0 +GLI1 GLI1 C2H2-type zinc finger protein; Oncoprotein; Transcription factor P08151 2735 12q13.3 human K815-sm 1873076606 HYGQVQVkPEQGCPV protein stabilization; ubiquitination; intracellular localization cell growth, induced; transcription, induced; signaling pathway regulation 28630282 1 0 0 inhibits ubiquitination, enhances Shh signaling +Esrp2 RBM35B RNA-binding Q8K0G8 77411 8|8 D3 mouse K413-ub 52473102 QAALRRHkGMLGKRY carcinogenesis, inhibited; RNA splicing, induced; cell growth, inhibited 26522722 1 0 0 +AFAP1L2 AFAP1L2 Activator; Cell cycle regulation Q8N4X5 84632 10q25.3 human Y54-p 462131 SSSSDEEyIYMNKVT molecular association, regulation PIK3R1(INDUCES) 19060924 1 5 176 +KAT5 Tip60 ACETYLTRANSFERASE; Acetyltransferase; EC 2.3.1.48; Nuclear receptor co-regulator; Nucleolus Q92993 10524 11q13.1 human K150-ac 52498004 NHRSTKRkVEVVSPA protein degradation; intracellular localization apoptosis, altered 25301942 1 0 0 HDAC3 increased the TIP60 half-life, and the ubiquitination level of TIP60, nuclear localization, cytoplasm and nucleus with HDAC3 expressed, TIP60 deacetylation increases its resistance to apoptosis +Syngap1 SynGAP iso3 GAP; GAP, Ras Q9QUH6-3 192117 20p12 rat S407-p 18710210 GKAKDFLsDMAMSEV RasGAP molecular association, regulation; intracellular localization HRas(INDUCES) 21382555 1 1 1 +Ppp1r1b DARPP-32 Motility/polarity/chemotaxis; Protein phosphatase, regulatory subunit Q60829 19049 11|11 D mouse T75-p 448048 RPNPCAYtPPSLKAV DARPP-32 activity, induced; enzymatic activity, induced 11572969; 16123776; 17301223 38 6 16 Phosphorylation of S566 is necessary for PP2A enzymatic activation and dephosphorylation of DARPP.; Mutation of T75 impaired a specific behavioral response (locomotor sensitization) to repeated cocaine administration. +CD19 CD19 Cell surface; Membrane protein, integral P15391 930 16p11.2 human Y348-p 454081 GSGPQNQyGNVLSLP activity, induced; molecular association, regulation SOS1(INDUCES); GRB2(INDUCES) 10706702 1 3 17 +FOCAD FOCAD Membrane protein, integral; Membrane protein, multi-pass Q5VW36 54914 9p21.3 human K587-ub 27195516 QWEKLIAkAASIRDI DUF3730 protein degradation 36184622 0 5 0 +Camk2b CAMK2B EC 2.7.11.17; KINASE; Kinase, protein; Protein kinase, CAMK; Protein kinase, Ser/Thr (non-receptor) P08413 24245 14q21 rat S331-p 48915803 ATMSTAAsGTTMGLV molecular association, regulation 26291163 1 1 0 inhibits interaction with F-actin, regulates synaptic plasticity +HECTD3 HECTD3 EC 6.3.2.-; EC 6.3.2.19; Ligase; UBIQUITIN LIGASE; Ubiquitin conjugating system; Ubiquitin ligase Q5T447 79654 1p34.1 human T157-p 150180307 ARLVPIDtPNHLQRQ molecular association, regulation apoptosis, inhibited CASP9(INDUCES) 28716524 1 1 0 +GRIK2 GluR6 Channel, calcium; Channel, ligand-gated; Membrane protein, integral; Membrane protein, multi-pass Q13002 2898 6q16.3 human C871-pa 27247800 ELRMSLKcQRRLKHK sumoylation; intracellular localization; phosphorylation; palmitoylation endocytosis, altered 37868810 2 0 0 palmitoylation maintains surface expression and regulates agonist -induced internalisation +JAK2 JAK2 EC 2.7.10.2; KINASE; Kinase, protein; Oncoprotein; Protein kinase, TK; Protein kinase, tyrosine (non-receptor) O60674 3717 9p24.1 human Y813-p 451492 NSLFTPDyELLTEND molecular association, regulation; phosphorylation APS(INDUCES); SH2-B-beta(INDUCES) 15767667; 16914724; 17565041 8 3 2 JAK2 Y1007/8 phosphorylation +Atoh1 ATOH1 Cell development/differentiation; DNA-binding; Transcription factor P48985 11921 6 C1|6 30.03 cM mouse S334-p 57761903 TSPRSHRsDGEFSPH protein degradation; molecular association, regulation; ubiquitination HUWE1(INDUCES) 27542412 1 1 0 +MTLN MTLN Membrane protein, integral Q8NCU8 205251 2q13 human T49-p 1881596600 LQDKLAAtQKKLDLA molecular association, regulation; intracellular localization Jun(DISRUPTS); NAT14(DISRUPTS) 36804379 1 0 0 +Prkdc DNAPK DNA repair, damage; EC 2.7.11.1; KINASE; Kinase, protein; Nucleolus; Protein kinase, Ser/Thr (non-receptor); Protein kinase, atypical P97313 19090 16 10.09 cM|16 A2 mouse S2053-p 455794 VQSYSYSsQDRKPTT DNAPKcs_CC3 DNA repair, induced Ku80(INDUCES) 28329681; 37307443 53 4 3 promoting S2053 phosphorylation; contributes to the synergy between XLF and DNA-PKcs in end-ligation, sites have distinct moderate roles in NHEJ +MKNK1 Mnk1 iso2 EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, CAMK; Protein kinase, Ser/Thr (non-receptor); Translation Q9BUB5-2 8569 1p33 human T209-p 447621 NSCTPITtPELTTPC Pkinase intracellular localization; enzymatic activity, induced 17590453 14 1 1 Leaves nucleus to cytoplasm upon phosphorylation. +SIK3 QSK EC 2.7.11.1; KINASE; Kinase, protein; Motility/polarity/chemotaxis; Protein kinase, CAMK; Protein kinase, Ser/Thr (non-receptor) Q9Y2K2 23387 11q23.3 human T469-p 480134 YLSMRRHtVGVADPR molecular association, regulation transcription, induced 14-3-3 beta(INDUCES) 22588126; 26048985 3 24 141 +GATA1 GATA1 DNA-binding; Transcription factor P15976 2623 Xp11.23 human S26-p 451232 VDPALVSsTPESGVF activity, induced transcription, induced 20101202 6 0 0 enhances survivin expression +MAPKAPK5 MAPKAPK5 EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, CAMK; Protein kinase, Ser/Thr (non-receptor); Tumor suppressor Q8IW41 8550 12q24.12-q24.13 human T182-p 450093 IDQGDLMtPQFTPYY Pkinase enzymatic activity, induced cell growth, altered 17254968; 20734105 6 10 94 +E2F1 E2F1 DNA-binding; Transcription factor Q01094 1869 20q11.22 human R109-me 57676506 AESSGPArGRGRHPG protein stabilization; molecular association, regulation; methylation cell cycle regulation; cell growth, inhibited; apoptosis, induced; transcription, induced DNA(INDUCES) 24076217 1 1 0 inhibits symmetrical methylation +IL5RA IL5RA Membrane protein, integral; Receptor, cytokine Q01344 3568 3p26.2 human K383-ub 1883407600 PAPKSNIkDLFVTTN protein degradation cell differentiation, inhibited 35982175 1 0 0 translocation to and degradation in lysosomes, March2/3 negatively regulates eosinophil maturation, March2/3 de?ciency promotes eosinophilic airway in?ammation +NINL Nlp Cell cycle regulation; Microtubule-binding Q9Y2I6 22981 20p11.21 human S185-p 15668109 WDSEDFGsPQKSCSP protein degradation; molecular association, regulation; protein stabilization; ubiquitination; intracellular localization cell cycle regulation PLK1(INDUCES) 20864540; 20890132 2 0 0 +S100A4 S100A4 Calcium-binding; Cell development/differentiation P26447 6275 1q21.3 human K22-sm 25352007 TFHKYSGkEGDKFKL S_100 intracellular localization transcription, induced 20685652 1 0 0 +SYN1 SYN1 Vesicle P17599 281510 cow Y301-p 478277 VVALTKTyATTEPFI Synapsin_C molecular association, regulation SYN1(INDUCES) 20530578 2 0 2 increases SYN1 oligomerization +SNX8 SNX8 Q9Y5X2 29886 7p22.3 human Y95-p 348335702 LFLKHVEyEVSSQRF molecular association, regulation transcription, induced IKKB(INDUCES) 29180417 1 0 0 +RUVBL1 RUVBL1 EC 3.6.4.12; Helicase; Motility/polarity/chemotaxis Q9Y265 8607 3q21.3 human K225-sm 2798313 EEYVPLPkGDVHKKK TIP49 intracellular localization cell growth, induced; transcription, induced 18087039 1 1 0 +NCOA3 SRC-3 ACETYLTRANSFERASE; Acetyltransferase; EC 2.3.1.48; Motility/polarity/chemotaxis; Nuclear receptor co-regulator; Transcription, coactivator/corepressor Q9Y6Q9 8202 20q13.12 human K1194-sm 3817000 SRQALELkMENPTAG transcription, inhibited 16760465 1 0 0 +Cacna1c CACNA1C Channel, calcium; Membrane protein, integral; Membrane protein, multi-pass P22002 24239 4q42 rat S1927-p 455278 ASLGRRAsFHLECLK CAC1F_C activity, induced; molecular association, regulation; intracellular localization; activity, inhibited PPP2CA(INDUCES); ITGB1(INDUCES) 16519540; 16554304; 17640527; 19478199; 21178109; 29180451; 34431981 31 3 0 membrane expression and distribution of CACNA1C along the dendrites of hippocampal neurons; differentially regulates the surface traffic of CACNA1C; regulates Cav1.2 channel gating +H3C1 H3 DNA-binding P68431 8350 6p22.2 human K4-m1 1458622 ____ARTkQTARKST Histone acetylation; molecular association, regulation; intracellular localization cell cycle regulation; carcinogenesis, inhibited; apoptosis, induced; cell growth, inhibited; transcription, induced; chromatin organization, altered; cell differentiation, induced; transcription, inhibited FOXA2(INDUCES); CHD-7(INDUCES); RBBP4(DISRUPTS); FALZ iso4(INDUCES); FALZ(INDUCES); STAT1(INDUCES); ING4(INDUCES) 15620353; 16728976; 17363312; 18787082; 19021773; 19187765; 19251738; 19805358; 20548336 44 10 9 +FSCN1 fascin Actin-binding; Cytoskeletal; Motility/polarity/chemotaxis Q16658 6624 7p22.1 human S38-p 3197465 FKVNASAsSLKKKQI Fascin cell growth, inhibited; cytoskeletal reorganization; cell motility, inhibited 28251354 1 7 0 reduce cell proliferation, cell migration and ?lopodia formation +MDM2 MDM2 EC 6.3.2.-; EC 6.3.2.19; Inhibitor; Ligase; NEDDYLATION LIGASE; Neddylation Ligase; Nucleolus; Oncoprotein; UBIQUITIN LIGASE; Ubiquitin conjugating system; Ubiquitin ligase Q00987 4193 12q15 human K446-sm 2793915 VICQGRPkNGCIVHG zf-C3HC4_3 protein degradation; protein stabilization; ubiquitination; enzymatic activity, induced apoptosis, inhibited 10892746 1 0 0 prevents ubiquitination of itself and induces ubiquitination of p53 thus stabilizing itself but causing degradation of p53 +CD274 PD-L1 Membrane protein, integral Q9NZQ7 29126 9p24.1 human Y112-p 1015586 KLQDAGVyRCMISYG V-set protein stabilization; molecular association, regulation ITM1(INDUCES) 31305264 1 1 0 glycosylation, prevents ubiquitination +Crebbp CBP ACETYLTRANSFERASE; Acetyltransferase; DNA-binding; EC 2.3.1.48; Motility/polarity/chemotaxis; Nuclear receptor co-regulator; Transcription, coactivator/corepressor P45481 12914 16 A1|16 2.4 cM mouse S2015-p 455574 QVSGPVMsSMPPGQW Creb_binding transcription, induced 15006641 1 0 0 +IKBKB IKKB EC 2.7.11.10; KINASE; Kinase, protein; Protein kinase, Other; Protein kinase, Ser/Thr (non-receptor) O14920 3551 8p11.21 human S750-p 5014910 QTEEEEHsCLEQAS_ O-GlcNAc glycosylation; molecular association, regulation; enzymatic activity, inhibited IKKG(DISRUPTS) 18957422; 19202066 2 0 0 S750 phosphorylation inhibits S733 O-GlcNAc and IKKB activity +PTPN6 SHP-1 EC 3.1.3.48; Motility/polarity/chemotaxis; PHOSPHATASE; Protein phosphatase, tyrosine (non-receptor) P29350 5777 12p13.31 human S591-p 454019 DKEKSKGsLKRK___ enzymatic activity, inhibited; protein conformation; phosphorylation carcinogenesis, inhibited 35258455 9 2 15 inhibits VAV1 dephosphorylation +TP53 p53 Activator; DNA-binding; Motility/polarity/chemotaxis; Nuclear receptor co-regulator; Transcription factor; Tumor suppressor P04637 7157 17p13.1 human K370-ac 458981 RAHSSHLkSKKGQST molecular association, regulation; protein stabilization; intracellular localization cell growth, inhibited; apoptosis, induced; transcription, induced; transcription, inhibited; transcription, altered BCL2L2(INDUCES); p21Cip1(DISRUPTS) DNA(INDUCES) 11099047; 11250899; 12421820; 14982997; 16291740; 18485870; 18697203; 19339993; 19377469; 21297583; 31680191; 34798143; 36257192; 9288740 22 3 0 promoting the C-terminal acetylation of p53 and may facilitate p53-dependent gene expression ; 20, 164, 305, 320, 370/372/373, 381/382/386 K-R mutants diminsished transactivation, and selective regulation of target genes expression through distinct mechanisms; arsenic induced overexpression of PUMA, P53 phosphorylation and acetylation, activation and accumulation of p53, PUMA disruption of Bcl-X complexes with pro-survival proteins resulting in apoptosis ; ZNF420 (Apak) represses p53 activity by attenuating its acetylation +PRAG1 SGK223 EC 2.7.10.2; KINASE; Kinase, protein; Motility/polarity/chemotaxis; Protein kinase, Other; Protein kinase, Ser/Thr (non-receptor) Q86YV5 157285 8p23.1 human Y413-p 449701 ATQPEPIyAESTKRK carcinogenesis, induced; cell motility, induced; cell adhesion, induced; cytoskeletal reorganization 35740644 2 33 699 +PRKCA PKCA EC 2.7.11.13; KINASE; Kinase, protein; Oncoprotein; Protein kinase, AGC; Protein kinase, Ser/Thr (non-receptor) P04409 282001 cow T497-p 448598 MDGVTTRtFCGTPDY Pkinase enzymatic activity, induced 8042986; 8349635 7 48 62 +SASS6 SAS6 Cell cycle regulation Q6UVJ0 163786 1p21.2 human S510-p 483310 NTIRSGIsPNLNVVD molecular association, regulation; intracellular localization cell cycle regulation NEDD1(DISRUPTS); STIL(DISRUPTS) 36356903 1 13 0 +CALD1 Caldesmon Actin-binding Q05682 800 7q33 human S714-p 456706 EGVRNIKsMWEKGNV Caldesmon cell motility, altered; cytoskeletal reorganization 16800003; 20128924 5 0 0 +JAK2 JAK2 EC 2.7.10.2; KINASE; Kinase, protein; Oncoprotein; Protein kinase, TK; Protein kinase, tyrosine (non-receptor) O60674 3717 9p24.1 human K991-sm 31899101 VENENRVkIGDFGLT PK_Tyr_Ser-Thr molecular association, regulation; intracellular localization GH receptor(DISRUPTS) 23581279 1 0 0 translocation into the nucleus +NR3C1 GR DNA-binding; Mitochondrial; Nuclear receptor; Transcription factor P04150 2908 5q31.3 human S404-p 5044100 SMRPDVSsPPSSSST protein degradation; molecular association, regulation; intracellular localization; protein conformation; activity, inhibited apoptosis, inhibited; transcription, induced FBXW7(INDUCES); NFkB-p65(DISRUPTS); p300(INDUCES) 18838540; 30250038 2 3 1 GR-alpha dimerization in promotes interaction with FBXW7; S404A mutant repressed many genes induced by WT, but overall induced more genes than WT. +EGLN1 EGLN1 EC 1.14.11.29; Oxidoreductase Q9GZT9 54583 1q42.2 human S125-p 7322687 ADPAAAAsPCRAAAG protein degradation; enzymatic activity, induced cell growth, inhibited; apoptosis, induced; transcription, inhibited 28199842; 34339019 3 25 5 HIF1a degradation; induces HIF1 degradation +TOM1L1 Srcasm Adaptor/scaffold O75674 10040 17q22 human Y460-p 451210 AVTTEAIyEEIDAHQ molecular association, regulation; intracellular localization endocytosis, altered GRB2(INDUCES); EGFR(INDUCES) 19798056 4 2 35 regulates EGF-stimulated endocytosis of EGFR +BRAF BRAF EC 2.7.11.1; KINASE; Kinase, protein; Oncoprotein; Protein kinase, Ser/Thr (non-receptor); Protein kinase, TKL P15056 673 7q34 human S429-p 447803 PQRERKSsSSSEDRN enzymatic activity, inhibited transcription, induced; cell growth, altered 10869359; 11293329; 18451171 7 1 32 +GLRA1 GLRA1 Membrane protein, integral; Membrane protein, multi-pass; Transporter; Transporter, ion channel P23415 2741 5q33.1 human S408-p 1869137000 PPPAPSKsPEEMRKL molecular association, regulation; ubiquitination neural plasticity; endocytosis, induced EPS15(INDUCES) 31433808; 32579955 2 1 0 +CDCA8 Borealin Cell cycle regulation; Nucleolus Q53HL2 55143 1p34.3 human T88-p 4203203 QALEEAAtADLDITE cell cycle regulation; cytoskeletal reorganization 18243099 2 0 0 chromosome alignment in mitosis +TPR TPR Membrane protein, peripheral; Nuclear envelope; Nucleoporin; Oncoprotein P12270 7175 1q31.1 human S2108-p 34424908 IQMTRRQsVGRGLQL intracellular localization 24938596 1 3 0 localizes to the nucleolar compartment during mitosis +HNRNPK hnRNP K RNA splicing; RNA-binding; Spliceosome P61978 3190 9q21.32 human T120-p 3193372 QLPSPTAtSQLPLES protein degradation 28423622 1 4 5 +CALD1 Caldesmon Actin-binding P12957 373965 chicken T627-p 15668101 GMKPAHTtAVVSKID Caldesmon molecular association, regulation Caldesmon(DISRUPTS) 20858431 0 1 0 enhances effect of S672 and S702 phosphorylation to weaken interaction +Gphn gephyrin Adaptor/scaffold; EC 2.10.1.1; EC 2.7.7.75 Q8BUV3 268566 12|12 C3 mouse S200-p 478374 LSPPPTTsPHKQTED molecular association, regulation PIN1(INDUCES) 17347650 2 8 0 +CDH5 CDH5 Cell adhesion; Membrane protein, integral; Motility/polarity/chemotaxis P33151 1003 16q21 human Y658-p 456048 GEMDTTSyDVSVLNS molecular association, regulation carcinogenesis, inhibited; cell motility, induced; cell adhesion, induced; transcription, induced; signaling pathway regulation; cell motility, altered; cell adhesion, altered; cytoskeletal reorganization CTNNB1(INDUCES); GPSM2(INDUCES); CTNND1(DISRUPTS) 16027153; 21037229; 25447529; 28712573; 33836597; 36797281 13 0 0 +Mapt Tau ACETYLTRANSFERASE; Acetyltransferase; Cytoskeletal P10637 17762 11 67.79 cM|11 E1 mouse S494-p 447928 SGYSSPGsPGTPGSR molecular association, regulation; intracellular localization; protein conformation; phosphorylation endocytosis, induced; cytoskeletal reorganization Tau(INDUCES) 21445308; 27834631; 31645758; 34220446; 36232909 175 57 116 increase oligomeric Tau secretion +GIT2 GIT2 GAP; GAP, ARF; Motility/polarity/chemotaxis Q14161 9815 12q24.11 human T195-p 38539203 VYGADPGtQDSSGKT Ank_2 molecular association, regulation; intracellular localization DNA repair, induced MDC1(INDUCES); H2AX(INDUCES); NBS1(INDUCES); PARP1(INDUCES) 25605334 1 1 0 nuclear foci formation +Traf3ip2 TRAF3IP2 Apoptosis; UBIQUITIN LIGASE; Ubiquitin conjugating system; Ubiquitin ligase Q8N7N6 103213 10|10 B1 mouse S311-p 21041604 KVILNDSsPQDQEER molecular association, regulation transcription, induced TRAF5(INDUCES); TRAF2(INDUCES); TRAF6(INDUCES) 21822257 1 1 0 +Map3k7 TAK1 EC 2.7.11.25; KINASE; Kinase, protein; Protein kinase, Ser/Thr (non-receptor); Protein kinase, TKL Q62073 26409 4|4 A5 mouse S412-p 455196 NGQPRRRsIQDLTVT activity, induced; enzymatic activity, induced; phosphorylation cell differentiation, altered; transcription, induced; signaling pathway regulation; transcription, altered 15647289; 32108376; 35803916 9 83 63 signaling node linking MAPK and NF-kB pathways, enhances phosphorylation of MAPKs; induces NFKB activity and hence IKK? phosphorylation +Sirt3 SIRT3 DEACETYLASE; Deacetylase; EC 3.5.1.-; Mitochondrial Q8R104 64384 7|7 F4-F5 mouse K57-ac 206219718 GGGSSEKkFSLQDVA protein degradation; acetylation; enzymatic activity, inhibited 28808064 1 1 0 Increased acetylation of LCAD. Impaired fatty acid oxidation +Adrb2 ADRB2 GPCR, family 1; Membrane protein, integral; Membrane protein, multi-pass; Receptor, GPCR P04274 101836719 hamster Y364-p 449810 NSNGKTDyMGEASGC activity, induced 11782469 5 0 0 +Scn2a SCN2A Channel, sodium; Membrane protein, integral; Membrane protein, multi-pass P04775 24766 3q21 rat S687-p 451194 EIRKRRSsSYHVSMD Na_trans_cytopl activity, induced 12359152 3 2 0 +TOP2A TOP2A EC 5.99.1.3; Isomerase P11388 7153 17q21.2 human S1337-p 477804 LDSDEDFsDFDEKTD intracellular localization; enzymatic activity, induced cell cycle regulation; apoptosis, induced 18171681 1 36 11 required for normal sister chromatid segregationi late mitosis +REST REST C2H2-type zinc finger protein; Cell development/differentiation; DNA-binding; Transcription factor Q13127 5978 4q12 human S1027-p 138107500 SDNMSEGsDDSGLHG protein degradation; ubiquitination 29156689 1 0 0 +Eps8 EPS8 Adaptor/scaffold Q08509 13860 6 G1|6 66.78 cM mouse Y497-p 450735 YAYSSSMyHRGPHAD phosphorylation carcinogenesis, induced; cell motility, induced; cell growth, induced; cell adhesion, induced 28214294 1 8 88 enhanced phosphorylation of ERK and FAK, increased cell adhesion and anchorage-dependent colony formation +EIF4G2 EIF4G2 RNA-binding; Translation; Translation initiation P78344 1982 11p15.4 human T508-p 449145 AQPPRTQtPPLGQTP molecular association, regulation translation, induced eIF2-beta(INDUCES) 29530922 1 67 47 during mitosis +VIM Vimentin Cytoskeletal; Motility/polarity/chemotaxis P08670 7431 10p13 human S39-p 451766 TTSTRTYsLGSALRP Filament_head activity, induced; protein degradation; protein stabilization; molecular association, regulation; phosphorylation carcinogenesis, induced; carcinogenesis, inhibited; carcinogenesis, altered; cell motility, induced; cell motility, altered; cytoskeletal reorganization; transcription, altered Vimentin(DISRUPTS) 11895474; 14762106; 19291697; 20856200; 31862882; 33525953 31 52 30 RNF208 targets Ser39 phosphorylation inducing polyubiquitination-mediated degradation, and suppressing metastasis.; Regulates VIF dynamics +Irak1bp1 IRAK1BP1 Transcription regulation Q9ESJ7 65099 9|9 E2 mouse S241-p 12524609 SATIHAAsKVFITFE SIMPL intracellular localization transcription, altered 17079333 1 0 0 nuclear localization +NR1I2 PXR DNA-binding; Nuclear receptor O75469 8856 3q13.33 human S305-p 9730702 TWECGRLsYCLEDTA Hormone_recep molecular association, regulation transcription, altered N-CoR1(INDUCES); FGR(DISRUPTS); RXRA(DISRUPTS) 19617467 2 0 0 inhibits transcription +TBC1D4 AS160 GAP; GAP, Rab O60343 9882 13q22.2 human T568-p 486326 NKAKRSLtSSLENIF molecular association, regulation 14-3-3 epsilon(INDUCES) 20410134 2 13 14 multiple sites (6P) mutant +MSN Moesin Cytoskeletal; Motility/polarity/chemotaxis P26038 4478 Xq12 human T558-p 447706 LGRDKYKtLRQIRQG ERM_C activity, induced; receptor internalization, induced; molecular association, regulation; intracellular localization; activity, inhibited; protein conformation; phosphorylation carcinogenesis, induced; cell motility, induced; cell motility, altered; cytoskeletal reorganization; cell adhesion, inhibited; signaling pathway regulation RhoGDI alpha(INDUCES); MCAM(INDUCES) 19255442; 19395553; 21725352; 21864676; 25799996; 33836044; 34603794; 36100057 40 8 29 +P2rx7 P2X7 Channel, ligand-gated; Membrane protein, integral; Membrane protein, multi-pass; Receptor, misc. Q64663 29665 12q16 rat Y343-p 450310 YIGSTLSyFGLATVC P2X_receptor; TM activity, induced cytoskeletal reorganization 11707406 1 0 0 +GNB1 G-beta 1 G protein; G protein, heterotrimeric; G protein, heterotrimeric beta P62873 2782 1p36.33 human H266-p 9643001 QELMTYShDNIICGI WD40 activity, induced 12486123; 17363702 3 0 0 receptor-independent activation of G proteins regulation of cAMP synthesis and contractility +LRP6 LRP6 Membrane protein, integral; Receptor, misc. O75581 4040 12p13.2 human S1607-p 21241903 HLYPPPPsPCTDSS_ activity, induced; molecular association, regulation signaling pathway regulation axin 1(INDUCES) 21887268 2 1 0 Regulation of Wnt pathway +NCL NCL DNA-binding; Helicase; Nuclear receptor co-regulator; Nucleolus; RNA-binding P19338 4691 2q37.1 human S328-p 31867151 PELKTGIsDVFAKND RRM_1 molecular association, regulation; intracellular localization transcription, induced DROSHA(DISRUPTS) RNA(DISRUPTS) 31182601 1 3 0 miR-93 and miR-484 interactions inhibited, increase KLF2 and eNOS protein expression +Prkce PKCE EC 2.7.11.13; KINASE; Kinase, protein; Protein kinase, AGC; Protein kinase, Ser/Thr (non-receptor) P16054 18754 17|17 E4 mouse S729-p 448789 QEEFKGFsYFGEDLM Pkinase_C intracellular localization; enzymatic activity, induced 11062054; 12640464; 19954762 20 17 7 PLKCE phosphorylated at S729, has Golgi-perinuclear localization and is increased in differetiated C2C12 cells. +Rps6ka1 p90RSK EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, AGC; Protein kinase, Ser/Thr (non-receptor); Translation Q63531 81771 5q36 rat T573-p 447993 AENGLLMtPCYTANF Pkinase activity, induced; phosphorylation; enzymatic activity, induced cell growth, induced; translation, induced 35648763; 9430688 20 16 180 induces eEF2K phosphorylation +Relb RELB Transcription factor Q04863 19698 7 A3|7 9.93 cM mouse S552-p 450233 AFGGGLLsPGPEAT_ RelB_transactiv protein degradation 11781828 2 16 1 +HIPK2 HIPK2 EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, CMGC; Protein kinase, Ser/Thr (non-receptor) Q9H2X6 28996 7q34 human K565-ub 3059906 YDTVNQSkTPFITHV protein degradation 18536714 1 0 0 +GMNN Geminin Cell cycle regulation; Motility/polarity/chemotaxis O75496 51053 6p22.3 human S201-p 475943 CAEGTVSsSTDAKPC apoptosis, altered 17261582 1 0 0 regulates geminin cleavage by caspase-3 +HSP90AA1 HSP90A Chaperone; Heat shock protein P07900 3320 14q32.31 human K327-ac 479815 WEDHLAVkHFSVEGQ HSP90 molecular association, regulation exocytosis, induced CHIP(DISRUPTS); TEBP(DISRUPTS); HSP40(DISRUPTS) 18559531 1 1 2 +RIPK2 RIPK2 EC 2.7.10.2; EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, Ser/Thr (non-receptor); Protein kinase, TKL; Protein kinase, tyrosine (non-receptor) O43353 8767 8q21.3 human Y474-p 4270705 DLIMKEDyELVSTKP CARD protein degradation; molecular association, regulation; ubiquitination; enzymatic activity, induced transcription, induced; signaling pathway regulation NOD1(INDUCES); NOD2(INDUCES) 21123652; 24958724; 31113864; 31350258 5 1 0 influences FCgammaRIII/FcgammaRIIB signaling (ROS production); induces riposome formation, reduces XIAP levels +EEF1A2 EEF1A2 Translation; Translation elongation Q05639 1917 20q13.33 human K55-m2 484742 EMGKGSFkYAWVLDK GTP_EFTU molecular association, regulation L3MBTL iso4(INDUCES) 23583077 0 6 11 +Apobec3 APOBEC3B iso3 EC 3.5.4.-; Hydrolase; RNA-binding Q99J72-3 80287 15 48.6 cM|15 E1 mouse S128-p 31825501 NLSLDIFsSRLYNVQ APOBEC2 enzymatic activity, induced 24453360 1 0 0 +Jak2 JAK2 EC 2.7.10.2; KINASE; Kinase, protein; Oncoprotein; Protein kinase, TK; Protein kinase, tyrosine (non-receptor) Q62120 16452 19 C1|19 23.73 cM mouse Y373-p 20615900 VSLIDGYyRLTADAH Jak1_Phl phosphorylation 21726629 1 1 0 induces autophosphorylation at Y1007 +DLGAP5 DLG7 Cell cycle regulation; Microtubule-binding Q15398 9787 14q22.3 human S725-p 456346 CLSSERMsLPLLAGG molecular association, regulation; intracellular localization TRIP11(INDUCES); GOLGA3(INDUCES); GOLM1(INDUCES); GM130(INDUCES); GRASP65(INDUCES) 37370099 2 15 3 +RAD52 RAD52 DNA repair, damage P43351 5893 12p13.33 human K344-ac 971232909 DAGDGVVkPSSRADP molecular association, regulation; intracellular localization DNA repair, induced RFA2(INDUCES); RPA3(INDUCES); RAD51(INDUCES); RPA1(INDUCES) 29590107 1 1 0 accumulation of RAD52 at DSB sites +PXN PXN Adaptor/scaffold; Cell adhesion; Cytoskeletal; Motility/polarity/chemotaxis P49023 5829 12q24.23 human S274-p 465490 DELMASLsDFKIQGL molecular association, regulation TACE(INDUCES) 23317503 1 4 0 induce lipid raft transfer +NES nestin Cytoskeletal P48681 10763 1q23.1 human T315-p 449820 AENSRLQtPGGGSKT intracellular localization cytoskeletal reorganization 37316833 3 8 1 regulates translocation of cortactin and Pfn-1 +GCM1 GCM1 DNA-binding; Transcription factor Q9NP62 8521 6p12.1 human S269-p 18788303 LYEKRKLsSSRTYSS protein stabilization; molecular association, regulation; acetylation transcription, induced DUSP23(INDUCES) 20855292; 26503785 3 1 0 +RET Ret EC 2.7.10.1; KINASE; Kinase, protein; Membrane protein, integral; Oncoprotein; Protein kinase, TK; Protein kinase, tyrosine (receptor) P07949 5979 10q11.21 human Y905-p 447627 DVYEEDSyVKRSQGR PK_Tyr_Ser-Thr molecular association, regulation; enzymatic activity, induced; phosphorylation cell growth, altered VAV1(INDUCES) 10445857; 11713247; 11956105; 12444552; 14711813; 16928683; 26147533; 28009299; 8637703 17 5 20 +DNMT1 DNMT1 Amino Acid Metabolism - cysteine and methionine; Cell development/differentiation; EC 2.1.1.37; METHYLTRANSFERASE; Methyltransferase; Methyltransferase, DNA; Transcription regulation P26358 1786 19p13.2 human K1415-ac 25171002 ILRDHICkDMSALVA DNA_methylase enzymatic activity, inhibited cell cycle regulation 21947282 1 1 0 +ILF3 NFAT90 DNA-binding; Nucleolus; RNA-binding; Transcription factor Q12906 3609 19p13.2 human T315-p 17734000 RQQREDItQSAQHAL DZF intracellular localization 24920670 3 0 0 cytoplasmic retention, which increases its association with and assembly of large RNA granules +NR1I2 PXR DNA-binding; Nuclear receptor O75469 8856 3q13.33 human Y249-p 27839403 HMADMSTyMFKGIIS Hormone_recep transcription, inhibited 22976785 1 0 0 +RUNX2 AML3 DNA-binding; Transcription factor Q13950 860 6p21.1 human S340-p 4169883 TDVPRRIsDDDTATS transcription, altered 19264160 4 9 0 +HMGB1 HMGB1 DNA repair, damage; Nuclear receptor co-regulator P09429 3146 13q12.3 human K3-ac 459196 _____MGkGDPKKPR molecular association, regulation chromatin organization, altered DNA(INDUCES) 15005629; 18241198 8 1 0 +ETS1 Ets-1 DNA-binding; Motility/polarity/chemotaxis; Oncoprotein; Transcription factor P14921 2113 11q24.3 human S276-p 35524906 SSQSSFNsLQRVPSY Ets1_N_flank protein stabilization; molecular association, regulation COP1(INDUCES) 25117710 1 0 0 +Mark2 MARK2 EC 2.7.11.1; EC 2.7.11.26; KINASE; Kinase, protein; Protein kinase, CAMK; Protein kinase, Ser/Thr (non-receptor) O08679 60328 1q43 rat S212-p 450068 KLDTFCGsPPYAAPE Pkinase enzymatic activity, inhibited; enzymatic activity, induced 14517247; 16257959; 9108484 6 12 11 +YBX1 YB-1 RNA processing; RNA splicing; RNA-binding; Transcription factor P67809 4904 1p34.2 human S176-p 470445 EKNEGSEsAPEGQAQ molecular association, regulation; intracellular localization cell growth, induced; transcription, induced 28077578 2 66 30 anchorage-independent growth, NF-?B DNA binding, nuclear translocation +APEX1 APE1 DNA repair, damage; DNA-binding; Deoxyribonuclease; EC 4.2.99.18; Endoplasmic reticulum; Hydrolase; Lyase; Nuclear receptor co-regulator; Nucleolus; Transcription, coactivator/corepressor P27695 328 14q11.2 human T233-p 14645304 NKKNAGFtPQERQGF Exo_endo_phos activity, induced; protein degradation; ubiquitination transcription, inhibited 21727086 2 0 0 induces gene suppression activity +FOXO3 FOXO3A Autophagy; DNA-binding; Oncoprotein; Transcription factor O43524 2309 6q21 human T179-p 20799901 SSPDKRLtLSQIYEW Forkhead phosphorylation transcription, induced 17711846 2 1 0 induces phosphorylation of other sites +RPN2 RPN2 EC 2.4.99.18; Glycan Metabolism - N-glycan biosynthesis; Membrane protein, integral; Membrane protein, multi-pass; Transferase P04844 6185 20q11.23 human K322-ub 12311757 SRATVLQkTSFTPVG Ribophorin_II protein degradation carcinogenesis, inhibited; cell growth, inhibited 36168628 1 4 23 +PELI1 PELI1 Adaptor/scaffold; EC 6.3.2.-; EC 6.3.2.19; Ligase; UBIQUITIN LIGASE; Ubiquitin conjugating system; Ubiquitin ligase Q96FA3 57162 2p14 human S293-p 7388014 FNTLAFPsMKRKDVV Pellino ubiquitination; enzymatic activity, induced 19264966 2 2 4 +PPP1R12A MYPT1 Motility/polarity/chemotaxis; PHOSPHATASE; Protein phosphatase, regulatory subunit O14974 4659 12q21.2-q21.31 human S445-p 452077 LGLRKTGsYGALAEI molecular association, regulation cell adhesion, altered 14-3-3 beta(INDUCES) 20354225 3 64 80 +ARFIP1 arfaptin 1 G protein regulator, misc. P53367 27236 4q31.3 human S132-p 3191827 LELVRKWsLNTYKCT Arfaptin molecular association, regulation; intracellular localization ARF1(DISRUPTS) 22981988; 25789876 3 32 43 critical for localization of ARFIP1 to Golgi; regulates insulin secretion; regulates retrograde transport +Syk Syk EC 2.7.10.2; KINASE; Kinase, protein; Protein kinase, TK; Protein kinase, tyrosine (non-receptor) P48025 20963 13 A5|13 27.41 cM mouse Y520-p 447662 LRADENYyKAQTHGK PK_Tyr_Ser-Thr enzymatic activity, inhibited; phosphorylation; enzymatic activity, induced transcription, induced 27609517; 33761438; 35196496; 36166754 50 9 72 +Cebpb C/EBP-beta DNA-binding; Motility/polarity/chemotaxis; Transcription factor P28033 12608 2 H3|2 87.58 cM mouse K102-ac 1881371302 YGAKPSKkPADYGYV protein degradation 34642310 1 1 0 SIRT2 decreases acetylation and ubiquitylation (not at K102 site) ; under ethanol stress +CRTC1 TORC1 iso2 Transcription factor Q6UUV9-2 23373 19p13.11 human S167-p 481986 TSWRRTNsDSALHQS TORC_M transcription, inhibited 29408765 7 17 5 +PDX1 PDX1 DNA-binding; Transcription factor P52945 3651 13q12.2 human S61-p 458401 LGALEQGsPPDISPY transcription, induced 12810726 3 1 0 +Rps6kb2 P70S6KB EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, AGC; Protein kinase, Ser/Thr (non-receptor); Translation Q9Z1M4 58988 19|19 A mouse S417-p 455990 SPRRLNSsPRTPISP phosphorylation 17980619 2 10 11 +GYS1 GYS1 Carbohydrate Metabolism - starch and sucrose; EC 2.4.1.11; Transferase P13807 2997 19q13.33 human S11-p 451605 NRTLSMSsLPGLEDW enzymatic activity, inhibited 19339242; 35793618 10 2 1 +RPA2 RFA2 DNA replication P15927 6118 1p35.3 human T21-p 448340 YGGAGGYtQSPGGFG molecular association, regulation; intracellular localization; phosphorylation cell cycle regulation; DNA repair, induced; apoptosis, altered; carcinogenesis, inhibited; transcription, altered; cell growth, altered p53(INDUCES); WRN(INDUCES) 17035231; 19704001; 19843584; 21107010; 29875999; 32989256; 35078814 21 0 0 +Prkd1 PRKD1 Autophagy; EC 2.7.11.13; KINASE; Kinase, protein; Motility/polarity/chemotaxis; Protein kinase, CAMK; Protein kinase, Ser/Thr (non-receptor) Q62101 18760 12|12 B3 mouse S203-p 449896 GVRRRRLsNVSLTGL enzymatic activity, induced 9765302 8 36 86 +APBB1 Fe65 Adaptor/scaffold; Apoptosis; Transcription regulation O00213 322 11p15.4 human Y547-p 451143 VQKFQVYyLGNVPVA PID molecular association, regulation transcription, induced RASD1(DISRUPTS) 18922798 2 1 0 part of a tripartite complex with APP +Dpysl2 CRMP-2 Microtubule-binding; Motility/polarity/chemotaxis P47942 25416 15p12 rat Y32-p 463168 VNDDQSFyADIYMED molecular association, regulation SCN9A(DISRUPTS) 27940916 3 4 62 +H2AX H2AX DNA repair, damage; DNA-binding; Helicase P16104 3014 11q23.3 human S139-p 448841 GKKATQAsQEY____ acetylation; molecular association, regulation; intracellular localization cell differentiation, inhibited; cell cycle regulation; apoptosis, altered; carcinogenesis, inhibited; apoptosis, induced; transcription, induced; transcription, altered; DNA repair, induced; DNA repair, altered; cytoskeletal reorganization Tip60(INDUCES); SMARCA2(INDUCES); PARP1(INDUCES); 53BP1(INDUCES); GCN5(INDUCES); MDC1(INDUCES); TEAD3(INDUCES); NBS1(INDUCES); H1B(DISRUPTS); SMARCA4(INDUCES); 53BP1(NOT_REPORTED); RAD50(INDUCES) 12607005; 12697768; 16377563; 18406329; 18758438; 18987440; 19305155; 20224553; 20356835; 20488183; 20637859; 20703100; 20921231; 22037398; 25487737; 26628370; 33512436; 33691101; 33731502; 33857133; 33986864; 34429760; 34711990; 34716195; 36060800; 36640924 289 32 29 +CTNNB1 CTNNB1 Actin-binding; Cell adhesion; Motility/polarity/chemotaxis; Nuclear receptor co-regulator; Oncoprotein; Transcription factor P35222 1499 3p22.1 human S184-p 1881579404 QLSKKEAsRHAIMRS protein stabilization; molecular association, regulation; intracellular localization; phosphorylation carcinogenesis, induced; transcription, induced; signaling pathway regulation GSK3B(DISRUPTS); BTRC(DISRUPTS); CK1A(DISRUPTS) 36808719 1 1 0 inhibits phosphorylation at Thr41 and Ser45 and ubiquitination, induces ?-catenin downstream signaling +PGAM1 PGAM1 Carbohydrate Metabolism - glycolysis and gluconeogenesis; EC 3.1.3.13; EC 5.4.2.11; EC 5.4.2.4; Isomerase; Phosphatase (non-protein) P18669 5223 10q24.1 human S118-p 455497 QVKIWRRsYDVPPPP His_Phos_1 enzymatic activity, inhibited 12189148 1 43 5 +PTPN5 STEP EC 3.1.3.48; Membrane protein, multi-pass; Motility/polarity/chemotaxis; PHOSPHATASE; Protein phosphatase, tyrosine (non-receptor) P54829 84867 11p15.1 human S268-p 20745211 EGFGYLMsPREESAR protein stabilization 21777200 1 0 0 +Kcnq3 Kv7.3 iso2 Channel, potassium; Membrane protein, integral; Membrane protein, multi-pass O88944-2 29682 7q34 rat Y349-p 453409 IQAAWRYyATNPNRL activity, inhibited 15304482 1 0 0 inhibition of K(+) current via reducing open probability. +MAD1L1 MAD1L1 Cell cycle regulation; Cytoskeletal Q9Y6D9 8379 7p22.3 human T716-p 334535800 LELFSRQtVA_____ MAD molecular association, regulation cell cycle regulation Mad2(INDUCES) 29162720; 32202322 2 0 0 +RAPGEF2 RAPGEF2 GEF; GEF, Ras; Motility/polarity/chemotaxis Q9Y4G8 9693 4q32.1 human S960-p 1245534 KKRVRRSsFLNAKKL activity, induced cell adhesion, altered 18796635 1 26 121 Rap1 activation +DEPTOR DEPTOR Apoptosis Q8TB45 64798 8q24.12 human S265-p 4723818 STSFMSVsPSKEIKI protein degradation; molecular association, regulation carcinogenesis, induced; apoptosis, inhibited; signaling pathway regulation mTOR(DISRUPTS) 19446321 2 23 0 PI3K-Akt signaling +Tfeb TFEB DNA-binding; Transcription factor Q9R210 21425 17 C|17 23.99 cM mouse S468-p 4785147 SSRRSSFsMEEGDVL DUF3371 protein stabilization transcription, induced 23599343 1 13 0 +RRAGA RRAGA G protein regulator, misc. Q7L523 10670 9p22.1 human K220-ub 15497049 VISHYQCkEQRDVHR Gtr1_RagA molecular association, regulation; phosphorylation autophagy, induced; signaling pathway regulation NPRL3(INDUCES); Raptor(DISRUPTS); DEPDC5(INDUCES); NPRL2(INDUCES) 25936802 1 1 1 interaction with GATOR1 complex, regulates mTORC1 signaling, regulates p70S6K phosphorylation +Stat6 STAT6 DNA-binding; Transcription factor P52633 20852 10 D3|10 74.59 cM mouse K383-ac 1880010904 TESVTEEkCAVLFST transcription, inhibited DNA(DISRUPTS) 31554795 1 1 0 Trim24-mediated Stat6 K383 acetylation disrupts Stat6?DNA association and inhibits M2 macrophage M2 polarization. +Tnk2 Ack EC 2.7.10.2; EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, TK; Protein kinase, tyrosine (non-receptor) O54967 51789 16|16 B3 mouse Y284-p 450946 LPQNDDHyVMQEHRK PK_Tyr_Ser-Thr enzymatic activity, induced carcinogenesis, induced 36376335 14 28 235 +PKM PKM Carbohydrate Metabolism - glycolysis and gluconeogenesis; Carbohydrate Metabolism - pyruvate; EC 2.7.1.40; KINASE; Kinase, other; Mitochondrial; Nucleotide Metabolism - purine P14618 5315 15q23 human K433-ac 11318768 GAIIVLTkSGRSAHQ PK_C molecular association, regulation; intracellular localization; enzymatic activity, inhibited; enzymatic activity, altered; enzymatic activity, induced; phosphorylation carcinogenesis, induced; apoptosis, induced; cell motility, induced; cell growth, induced; transcription, induced; signaling pathway regulation; transcription, altered PKM iso2(DISRUPTS); PKM(DISRUPTS); DDB2(INDUCES); Exportin-4(DISRUPTS); CTNNB1(INDUCES) Other(INDUCES); Other(DISRUPTS) 24120661; 26410533; 26787900; 32460017; 32989054; 34016961; 35821123 8 4 1 K433 acetylation inhibits PKM pyruvate kinase activity and promoting aerobic glycolysis; enzymatic activity decreases as the pH is increased from 7.0 to 8.0 ; PCB2 activates SIRT3 deacetylates K433 PKM2 inducing an antiapoptotic effect reducing lung I/R injury.; required for tumor growth ; interaction with fructose 1, 6-bisphosphate, causing a disruption in PKM oligomerization, dimeric PKM translocate into the nucleus +GATA1 GATA1 DNA-binding; Transcription factor P17678 396450 chicken K218-ac 459079 RNRKVSSkGKKRRPP molecular association, regulation; protein conformation cell differentiation, induced; transcription, induced DNA(INDUCES) 9859997 6 1 0 +CCND1 CCND1 Activator; Cell cycle regulation; Nuclear receptor co-regulator; Oncoprotein P24385 595 11q13.3 human K269-ub 12159005 AQQNMDPkAAEEEEE Cyclin_C protein degradation; molecular association, regulation; intracellular localization cell growth, inhibited PSMD7(INDUCES) 19767775 1 0 0 +NEDD9 Cas-L Adaptor/scaffold; Motility/polarity/chemotaxis Q14511 4739 6p24.2 human Y12-p 452009 NLMARALyDNVPECA SH3_9 molecular association, regulation cytoskeletal reorganization Src(INDUCES); FAK(INDUCES) 29876004 1 1 3 MMP9 secretion and invadopodia formation requires Y12 phosphorylation and SH3 domain. +PARD3B PAR3-beta Adaptor/scaffold; Motility/polarity/chemotaxis Q8TEW8 117583 2q33.3 human S746-p 455652 LGLKKSSsLESLQTA molecular association, regulation 14-3-3 zeta(INDUCES) 15721295 1 25 0 +GYS1 GYS1 Carbohydrate Metabolism - starch and sucrose; EC 2.4.1.11; Transferase P13807 2997 19q13.33 human S727-p 457615 STPSEPLsPTSSLGE phosphorylation 34758018 2 20 3 primes phopshorylation at S641 +Nkx2-5 NKX2-5 DNA-binding P42582 18091 17 A3.3|17 13.6 cM mouse K51-sm 25344500 SCMLAAFkPEAYSGP cell growth, induced; transcription, altered 21677783 1 0 0 +CARD9 CARD9 Adaptor/scaffold Q9H257 64170 9q34.3 human T533-p 1206000 TGSDNTDtEGS____ activity, inhibited 17936701 1 1 0 impairs ability of CARD9 to activate NF-kB +NEDD4 NEDD4 iso4 EC 6.3.2.-; EC 6.3.2.19; Ligase; Nuclear receptor co-regulator; UBIQUITIN LIGASE; Ubiquitin conjugating system; Ubiquitin ligase P46934-4 4734 15q21.3 human Y585-p 4155214 DGEKGLDyGGVAREW protein conformation; enzymatic activity, induced endocytosis, induced; cell growth, induced; signaling pathway regulation 25292214 1 1 3 +Map2 MAP2 Cytoskeletal; Motility/polarity/chemotaxis P15146 25595 9q32 rat T1619-p 4704347 PPSYSSRtPGTPGTP molecular association, regulation cytoskeletal reorganization 25309320 1 10 7 fractionated with microtubules, protrusion growth, regulates basal dendrite architecture in vivo +Arhgdia RhoGDI alpha Apoptosis; Cell adhesion; Cell development/differentiation; G protein regulator, misc.; Motility/polarity/chemotaxis Q99PT1 192662 11|11 E2 mouse S101-p 452195 LESFKKQsFVLKEGV Rho_GDI intracellular localization; enzymatic activity, induced 37364105 6 11 1 induces Rac1 activity and GLUT4 translocation +MORC2 MORC2 DNA-binding Q9Y6X9 22880 22q12.2 human T582-p 30982293 LEALQKTtPIRSQAD protein stabilization; molecular association, regulation carcinogenesis, induced HSC70(DISRUPTS) 32401166 1 1 0 +KCNJ13 KCNJ13 Channel, potassium; Membrane protein, integral; Membrane protein, multi-pass O60928 3769 2q37.1 human S287-p 6039503 EICQRRTsYLPSEIM IRK_C activity, induced 18976636 1 0 0 +Bub1b BUB1B EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, Other; Protein kinase, Ser/Thr (non-receptor); Tumor suppressor Q9Z1S0 12236 2|2 E5 mouse K243-ac 7761217 SRVGGALkAPGQSRG molecular association, regulation cell cycle regulation; carcinogenesis, inhibited; cytoskeletal reorganization 23878276; 25559578 5 1 0 checkpoint maintenance, chromosome-spindle attachment; acetylation site necessary for embryonic development, spontaneous tumorigenesis in K243R/+ mutant mice, mutant shows: aneuploidy and premature sister chromatid separations, weakened spindle assembly checkpoint, defects in kinetochore-microtubule attachments acetylation of at BubR1 is required for recruiting PP2A-B56-alpha phosphatase to kinetochore +E2F4 E2F4 DNA-binding E1BUH4 chicken T261-p 25571901 PSSTQPStPTPSSTQ cell cycle regulation; apoptosis, induced 22586272 1 0 0 +Atg5 ATG5 Apoptosis; Autophagy; Ubiquitin conjugating system Q99J83 11793 10 B2|10 23.24 cM mouse K118-ub 1883300102 DLLHCPSkDAVEAHF protein degradation; ubiquitination autophagy, induced 35900990 1 0 0 USP22 promotes the degradation of NLRP3 via ATG5-mediated autophagy +SNCAIP SNCAIP Vesicle Q9Y6H5 9627 5q23.2 human S556-p 469990 AQKSEGKsLPSSPSS SNCAIP_SNCA_bd protein stabilization; molecular association, regulation; protein processing 14-3-3 beta(INDUCES) 16174773 1 1 3 14-3-3 enhances phosphorylation of SNCIAP by GSK3B. Inhibition of GSK3B increases formation of SNCIAP cytoplasmic inclusion bodies. +KIF4A KIF4A Microtubule-binding; Motor O95239 24137 Xq13.1 human T1161-p 459852 FFNPVCAtPNSKILK intracellular localization cell cycle regulation 29771379 1 7 0 regulates its chromosomal localization in early mitosis; critical for the functions of Kif4A required for early mitotic progression +H3C1 H3 DNA-binding P68431 8350 6p22.2 human T6-p 13321500 __ARTKQtARKSTGG Histone molecular association, regulation; methylation apoptosis, inhibited; transcription, induced PHF21A(DISRUPTS); ING2(DISRUPTS); RAG2(DISRUPTS); AIRE(DISRUPTS) 20190764; 20228790; 25482560; 25553095 5 2 0 high phosphorylation levels associated with a phenotype of resistance to TMZ+Irrad-induced cell death +BLM BLM DNA repair, damage; DNA replication; EC 3.6.4.12; Helicase P54132 641 15q26.1 human K225-ub 28132101 IDLTEEQkDDSEWLS BLM_N molecular association, regulation; intracellular localization DNA repair, inhibited RAP80(INDUCES) 23708797 1 0 0 +SEPTIN4 SEPT4 Apoptosis; Cell development/differentiation; Cytoskeletal; Hydrolase O43236 5414 17q22 human K174-ub 27208422 TDLYRDRkLLGAEER Septin protein degradation; ubiquitination 31924572 1 1 0 +Acadl ACADL EC 1.3.8.8; Lipid Metabolism - fatty acid; Mitochondrial; Oxidoreductase P51174 11363 1 C3|1 33.64 cM mouse K322-ac 1204119 KQRKAFGkTVAHIQT Acyl-CoA_dh_1 protein conformation; enzymatic activity, induced 24121500 1 3 1 +PCK1 PCK1 Carbohydrate Metabolism - citrate (TCA) cycle; Carbohydrate Metabolism - glycolysis and gluconeogenesis; Carbohydrate Metabolism - pyruvate; EC 4.1.1.32; KINASE; Kinase, other; Lyase; Protein kinase, Ser/Thr (non-receptor) P35558 5105 20q13.31 human K244-ac 1877232013 GNSLLGKkCFALRMA PEPCK_N enzymatic activity, inhibited 33334880 0 1 0 +CDCA5 CDCA5 Cell cycle regulation Q96FF9 113130 11q13.1 human S164-p 9316471 TSTPGRRsCFGFEGL Sororin activity, inhibited cell cycle regulation SCC-112(DISRUPTS) 23901111 1 4 1 +H3C14 HIST2H3A/C/D DNA-binding Q71DI3 126961 1q21.2 human R8-m2 18465154 ARTKQTArKSTGGKA Histone chromatin organization, altered; transcription, induced 20075197 1 0 0 +Akt2 Akt2 EC 2.7.11.1; KINASE; Kinase, protein; Oncoprotein; Protein kinase, AGC; Protein kinase, Ser/Thr (non-receptor) P47197 25233 1q21 rat S474-p 448520 RTHFPQFsYSASIRE Pkinase_C activity, induced 22846604 37 9 55 Glucose uptake in skeletal muscles +ZMYM2 ZNF198 Transcription factor Q9UBW7 7750 13q12.11 human S305-p 483897 QPGVDSLsPVASLPK molecular association, regulation; ubiquitination HDAC1(DISRUPTS); LSD1(DISRUPTS) 25855382 1 34 3 +CLEC1B CLEC1B Membrane protein, integral; Receptor, misc. Q9P126 51266 12p13.31-p13.2 human Y7-p 13244602 _MQDEDGyITLNIKT molecular association, regulation; activity, inhibited Syk(INDUCES) 20154219 1 0 0 Clec1b Y7F mutant has an inhibitory effect on signaling by wt Clec1b +APH1A APH1A Apoptosis; Endoplasmic reticulum; Membrane protein, integral; Membrane protein, multi-pass Q96BI3 51107 1q21.2 human S110-p 1877641904 SLSEDGRsPISIRQM Aph-1 molecular association, regulation; enzymatic activity, altered ARRB2(INDUCES) 35858570 1 1 0 +SOX10 SOX10 Cell development/differentiation; DNA-binding; Transcription factor P56693 6663 22q13.1 human K246-sm 3875803 PTPPTTPkTELQSGK molecular association, regulation transcription, inhibited EGR2(DISRUPTS); PAX3(DISRUPTS) 16494873 1 0 0 +Pdzrn3 PDZRN3 EC 6.3.2.-; Ligase; UBIQUITIN LIGASE; Ubiquitin conjugating system; Ubiquitin ligase Q69ZS0 55983 6|6 D3 mouse T956-p 25304558 EERSGLTtDDDAMSE protein degradation cell motility, inhibited 34135125 1 4 2 +H3C1 H3 DNA-binding P68431 8350 6p22.2 human R8-me 62566200 ARTKQTArKSTGGKA Histone acetylation 15485929 1 0 0 +WNK4 WNK4 EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, Other; Protein kinase, Ser/Thr (non-receptor) Q96J92 65266 17q21.2 human S1201-p 23073728 FPTSRRNsLQRSEPP activity, induced; phosphorylation 23054253 2 1 1 decrease phosphorylation of S1217; regulates NKCC2 activity +Il7r IL7R Membrane protein, integral; Receptor, cytokine P16872 16197 15 A1|15 4.16 cM mouse Y449-p 451291 VLNQEEAyVTMSSFY phosphorylation translation, altered; cell growth, induced; cell differentiation, induced; apoptosis, inhibited; transcription, induced; signaling pathway regulation; transcription, altered 15226449; 17602185; 25143441; 31924648; 35021100 7 0 0 induces STAT5 phosphorylation; PI3K/STAT5 signaling, Regulates TCF1 expression and T cell development; induce phosphorylation of STAT5 and Akt, regulates STAT5 and PI3/Akt pathways; Proteomics analysis of WT and Y449F IL7R shows that various proteins are effected (both upregulated and downregulated differences). Not specified whether they are transcriptional or translational effects. For example, GIMAP4, Annexin A6, STAT1, CDC42 were downregulated. BIT1 and FKBP51 were upregulated in the mutant. +NFKB2 NFkB-p100 DNA-binding; Oncoprotein; Transcription factor Q00653 4791 10q24.32 human K689-sm 3055609 TLTRLLLkAGADIHA Ank_2 protein processing; phosphorylation signaling pathway regulation 18617892 1 0 0 activation of alternative NF-kB pathway +PPP1R12B PPP1R12B Activator; Motility/polarity/chemotaxis; Protein phosphatase, regulatory subunit O60237 4660 1q32.1 human T646-p 478177 ARQTRRStQGVTLTD activity, inhibited 16431080 1 16 78 inhibits phosphatase activity of PP1c-delta +TERT TERT DNA-binding; EC 2.7.7.49; Nucleolus; Transferase O14746 7015 5p15.33 human S227-p 11418800 GARRRGGsASRSLPL intracellular localization; enzymatic activity, induced apoptosis, inhibited; cytoskeletal reorganization KPNA1(INDUCES); KPNA5(INDUCES); KPNB1(INDUCES) 10224060; 22366458; 25999477 3 0 0 facilitates nuclear import of TERT; nuclear import +ETFB ETFB Mitochondrial; Oxidoreductase P38117 2109 19q13.41 human K200-m3 15381912 ATLPNIMkAKKKKIE ETF enzymatic activity, inhibited 25416781 2 2 1 inhibitory effect on the transfer of electrons +MAPK6 ERK3 EC 2.7.11.24; KINASE; Kinase, protein; Protein kinase, CMGC; Protein kinase, Ser/Thr (non-receptor) Q16659 5597 15q21.2 human S705-p 13830501 TPSAMKSsPQIPHQT protein stabilization 20236090 1 2 0 +ACTL6A BAF53A O96019 86 3q26.33 human S195-p 1876807200 LQQGIVKsPLAGDFI Actin molecular association, regulation apoptosis, induced; transcription, induced RASSF6(INDUCES) 34898277 1 0 0 +Foxk2 FOXK2 DNA-binding; Transcription factor Q3UCQ1 68837 11|11 E2 mouse S200-p 1876808206 GTISAANsCPSSPRG intracellular localization carcinogenesis, induced; transcription, altered 35412849 1 1 0 +PBK PBK Cancer Testis Antigen (CTA); EC 2.7.12.2; KINASE; Kinase, protein; Protein kinase, Other; Protein kinase, Ser/Thr (non-receptor); Protein kinase, dual-specificity (non-receptor) Q96KB5 55872 8p21.1 human T9-p 451735 EGISNFKtPSKLSEK molecular association, regulation; phosphorylation; enzymatic activity, induced carcinogenesis, induced; cytoskeletal reorganization; signaling pathway regulation CCNB1(INDUCES); TUBA4A(INDUCES); CDK1(INDUCES) 15541388; 16291951; 29904102 6 12 2 induces phosphorylation of PRPK, regulates Pbk/PRPK pathway +RPL11 RPL11 Motility/polarity/chemotaxis; Nucleolus; Ribosomal; Translation P62913 6135 1p36.11 human K145-ne 12067615 GFSIADKkRRTGCIG Ribosomal_L5_C protein stabilization; intracellular localization 19713960 1 0 0 +SQSTM1 SQSTM1 Autophagy; Nuclear receptor co-regulator; Ubiquitin conjugating system Q13501 8878 5q35.3 human K435-ub 4953938 LDTIQYSkHPPPL__ UBA_5 intracellular localization signaling pathway regulation 33472082 1 12 94 recruitment of vesicle adaptors to RNF26, inhibition of EGF-induced AKT signaling +CHEK2 Chk2 EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, CAMK; Protein kinase, Ser/Thr (non-receptor); Tumor suppressor O96017 11200 22q12.1 human T387-p 447552 LMRTLCGtPTYLAPE Pkinase intracellular localization; protein conformation; enzymatic activity, induced cell cycle regulation 11390408; 12805407; 15361830; 16794575; 17698850; 20713355 18 5 0 +BANP BANP Tumor suppressor Q8N9N5 54971 16q24.2 human T352-p 41301701 PSEPMMStPPPASEL intracellular localization 26080397 1 0 0 cytoplasmic localization +PKM PKM Carbohydrate Metabolism - glycolysis and gluconeogenesis; Carbohydrate Metabolism - pyruvate; EC 2.7.1.40; KINASE; Kinase, other; Mitochondrial; Nucleotide Metabolism - purine P14618 5315 15q23 human T129-p 27110042 GLIKGSGtAEVELKK PK molecular association, regulation; phosphorylation PKM(DISRUPTS) 32054489 1 8 0 blocks the conversion of tetramer to dimer; PKM dimerization inhibited; inhibits STAT3 phosphorylation +SLC25A4 SLC25A4 Membrane protein, integral; Membrane protein, multi-pass; Mitochondrial; Transporter; Transporter, SLC family P12235 291 4q35.1 human Y191-p 462625 IIIYRAAyFGVYDTA Mito_carr; TM cell growth, altered 20007455 1 13 344 required for an efficient oxidative growth in yeast +KIF23 KIF23 Microtubule-binding; Motility/polarity/chemotaxis; Motor Q02241 9493 15q23 human S716-p 453934 QLHRRSNsCSSISVA molecular association, regulation; intracellular localization LIMK1(INDUCES) 25786116 2 4 0 activation of LIMK1 on centrosomes; localizes to the centrosome during mitosis, required for cytokinesis +DTD1 DTD1 DNA replication; EC 3.1.-.-; Hydrolase Q8TEA8 92675 20p11.23 human S205-p 485755 GAEGDVSsEREP___ molecular association, regulation cell cycle regulation; cell growth, induced MCM7(INDUCES); MCM3(DISRUPTS) 25258324 1 41 5 decreases DTD1 incorporation into HMW, supports DNA replication initiation +NHEJ1 NHEJ1 DNA repair, damage Q9H9Q4 79840 2q35 human T181-p 35499302 LIRDRLKtEPFEENS protein degradation; molecular association, regulation; ubiquitination; intracellular localization 14-3-3 beta(INDUCES); XRCC4(DISRUPTS) 25661488 1 1 0 interaction with 14-3-3-beta, for cytoplasmic retention of XLF, phosphorylation impairs NHEJ and V(D)J recombination +PTEN PTEN Carbohydrate Metabolism - inositol phosphate; EC 3.1.3.16; EC 3.1.3.48; EC 3.1.3.67; Motility/polarity/chemotaxis; Nuclear receptor co-regulator; PHOSPHATASE; Phosphatase, lipid; Tumor suppressor P60484 5728 10q23.31 human Y68-p 7331394 HKNHYKIyNLCAERH protein stabilization 22891331 2 1 0 +Stat3 STAT3 DNA-binding; Motility/polarity/chemotaxis; Nuclear receptor co-regulator; Transcription factor P42227 20848 11 D|11 63.82 cM mouse S754-p 35494901 SAGGQFEsLTFDMDL transcription, inhibited 28188292 3 0 0 +APC APC Motility/polarity/chemotaxis; Tumor suppressor P25054 324 5q22.2 human S2793-p 10211300 YNPSPRKsSADSTSA EB1_binding molecular association, regulation EB1(DISRUPTS) 19632184 1 0 0 +C2CD5 CDP138 Vesicle Q86YS7 9847 12p12.1 human S197-p 21398500 EARQRLIsLMSGELQ molecular association, regulation; intracellular localization exocytosis, induced; signaling pathway regulation GLUT4(INDUCES) 21907143 1 1 0 GLUT4 translocation induced and regulates Akt2 signaling pathway +LAMP2 LAMP2 Membrane protein, integral P13473 3920 Xq24 human T211-p 386186605 TVPSPTTtPTPKEKP protein degradation; intracellular localization; protein conformation carcinogenesis, induced; autophagy, induced; cell growth, induced 29176575; 33685990 2 0 0 +NFKBIA IkB-alpha DNA-binding; Inhibitor P25963 4792 14q13.2 human K21-ub 485773 EGPRDGLkKERLLDD activity, induced; protein degradation; ubiquitination; intracellular localization transcription, induced 7479976; 8550590; 8649784; 9724653; 9990853 9 0 0 +SNAI2 Snail2 Apoptosis; C2H2-type zinc finger protein; Motility/polarity/chemotaxis; Transcription factor O43623 6591 8q11.21 human S92-p 25603910 RVSPPPPsDTSSKDH protein degradation; intracellular localization cell motility, inhibited; transcription, induced CHIP(INDUCES) 22727060; 23851495 2 1 0 WT localizes in cytosol and nucleus; transcriptional activity of E-cadherin; Snail2 luciferase construct, may affect lung metastasis in NSCLC.; mutants enhance epithelial-mesenchymal transition (EMT) +Mfn2 MFN2 Cell cycle regulation; Cytoskeletal; EC 3.6.5.-; Hydrolase; Membrane protein, integral; Membrane protein, multi-pass; Mitochondrial Q80U63 170731 4|4 E2 mouse T111-p 17402150 RTSNGKStVINAMLW Dynamin_N cell differentiation, inhibited; autophagy, induced 32165499 3 1 0 induces mitophagy +SRC Src EC 2.7.10.2; KINASE; Kinase, protein; Oncoprotein; Protein kinase, TK; Protein kinase, tyrosine (non-receptor) P00523 396442 chicken Y416-p 448234 RLIEDNEyTARQGAK PK_Tyr_Ser-Thr phosphorylation; enzymatic activity, induced neural plasticity; cell motility, altered; cytoskeletal reorganization; cell adhesion, altered; cell growth, altered 11909938; 14593208; 16024778; 2474754; 2582236; 27881656; 3103925; 3103926; 34616310 447 103 3046 +Zfp110 ZNF274 C2H2-type zinc finger protein; DNA-binding; Nucleolus; Transcription factor Q923B3 65020 7 A1|7 7.66 cM mouse K15-ub 1872271902 TWPHESVkFEDVSLT KRAB intracellular localization apoptosis, induced 16252010 1 0 0 nuclear localization +GEMIN5 GEMIN5 Nuclear receptor co-regulator; RNA processing; RNA splicing; RNA-binding Q8TEQ6 25929 5q33.2 human T897-p 83111227 RFHLGLFtDRATLYR molecular association, regulation; protein conformation translation, induced G3BP-2(INDUCES); ELF4(INDUCES); FMR1(INDUCES); AGO2(INDUCES); IGF2BP2(INDUCES); IGF2BP3(INDUCES) 36420152 1 1 0 +APC APC Motility/polarity/chemotaxis; Tumor suppressor P25054 324 5q22.2 human S1392-p 450135 SRCTSVSsLDSFESR APC_r transcription, altered 11487578 2 3 0 +Kcnj1 ROMK Channel, potassium; Membrane protein, integral; Membrane protein, multi-pass P35560 24521 8q21 rat S313-p 2461200 ATCQVRTsYVPEEVL IRK_C activity, induced; protein conformation 18311184 5 0 0 +BTLA BTLA Membrane protein, integral Q7Z6A9 151888 3q13.2 human Y243-p 1869334003 MQEGSEVySNPCLEE phosphorylation signaling pathway regulation 32437509 1 0 0 inhibits IL2 production, phosphorylation of CD3Z and CD28, and hence T cell signaling +PLAGL2 PLAGL2 C2H2-type zinc finger protein; DNA-binding Q9UPG8 5326 20q11.21 human K356-sm 483051 YLPDKLPkVEVDSFL intracellular localization cell growth, induced; transcription, inhibited 16207715 3 0 0 +Olig2 OLIG2 Oncoprotein; Transcription factor Q9EQW6 50913 16 C3.3|16 52.6 cM mouse K76-sm 1869334000 KLGGGGFkSSSSSTS molecular association, regulation cell cycle regulation; carcinogenesis, induced; apoptosis, inhibited; DNA repair, inhibited; transcription, inhibited HDAC1(INDUCES) DNA(INDUCES) 32483381 1 1 0 +DOCK8 DOCK8 GEF; GEF, misc.; Motility/polarity/chemotaxis Q8NF50 81704 9p24.3 human S2077-p 3929061 KPIFRVEsQKRDSFH molecular association, regulation cell motility, induced LRCH1(DISRUPTS) 28028151 1 8 17 +Ybx1 YB-1 RNA processing; RNA splicing; RNA-binding; Transcription factor P62960 22608 4|4 D2.1 mouse Y97-p 15416754 KKNNPRKyLRSVGDG CSD carcinogenesis, induced; translation, induced 36044842 2 2 3 +STT3A Chk1 EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, CAMK; Protein kinase, Ser/Thr (non-receptor); Tumor suppressor Q8AYC9 374260 chicken S301-p 465528 IRSDTDFsPVKSALG enzymatic activity, induced cell cycle regulation 21765472 5 22 5 +Robo3 ROBO3 Membrane protein, integral Q9Z2I4 19649 9|9 A4 mouse Y1019-p 37043702 ASGEGPVySTIDPVG cell motility, induced 25433640 1 0 0 mediating Robo3 attraction +TYMS TYMS Cofactor and Vitamin Metabolism - one carbon pool by folate; DNA repair, damage; EC 2.1.1.45; METHYLTRANSFERASE; Methyltransferase; Mitochondrial; Nucleotide Metabolism - pyrimidine P04818 7298 18p11.32 human T251-gl 1875343302 KPGDFIHtLGDAHIY Thymidylat_synt protein stabilization TYMS(INDUCES) 34845374 1 1 0 dimer stabilization by intra- and inter-monomer interactions +PDCD4 PDCD4 Apoptosis; Tumor suppressor Q53EL6 27250 10q25.2 human S71-p 1211014 RKNSSRDsGRGDSVS protein degradation; molecular association, regulation cell cycle regulation; translation, altered; cell growth, altered BTRC(INDUCES) 17053147 1 16 21 +Myod1 MyoD DNA-binding; RNA splicing; Transcription factor P10085 17927 7 B3|7 30.03 cM mouse Y30-p 449872 FETADDFyDDPCFDS Basic molecular association, regulation; activity, inhibited DNA repair, induced NBS1(INDUCES) DNA(INDUCES) 12415271; 24056763 3 0 0 +RBL2 Rb-like 2 Transcription, coactivator/corepressor; Tumor suppressor Q08999 5934 16q12.2 human S1112-p 449743 LLEDGSEsPAKRICP molecular association, regulation cell cycle regulation E2F4(DISRUPTS) 11157749; 12006580 3 20 1 +PDE4A PDE4A iso2 EC 3.1.4.53; Nucleotide Metabolism - purine; Phosphodiesterase P27815-2 5141 19p13.2 human S119-p 458389 ATSQRREsFLYRSDS enzymatic activity, induced 15738310 4 20 1 +Prkab1 AMPKB1 Autophagy; KINASE; Protein kinase, regulatory subunit Q9R078 19079 5|5 F mouse S108-p 448522 SKLPLTRsQNNFVAI AMPK1_CBM phosphorylation; enzymatic activity, induced autophagy, induced; signaling pathway regulation 33658485; 36409897 11 64 2 induces ACC phosphorylation; induces AMPK pathway, reduces lipid deposition +STK38 NDR1 EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, AGC; Protein kinase, Ser/Thr (non-receptor) Q15208 11329 6p21.31 human S281-p 448828 NRRQLAFsTVGTPDY Pkinase activity, induced; molecular association, regulation; intracellular localization; phosphorylation; enzymatic activity, induced cytoskeletal reorganization; signaling pathway regulation MOBP(INDUCES); CCND1(INDUCES) 12493777; 16135814; 22445341; 23897809; 31679687 6 2 15 reduction in dendritic branching and length ; in glucose starvation +Ifi204 IFI16 Transcription factor P0DOV2 15951 1 H3|1 80.63 cM mouse R12-me 1877257500 YKRIVLLrGLECINK PYRIN signaling pathway regulation 32641491 1 0 0 dsDNA-stimulated STING pathway activation +RIN1 Rin1 GEF; GEF, Rab Q13671 9610 11q13.2 human S292-p 4949757 QLLRRESsVGYRVPA molecular association, regulation cell motility, altered; cell motility, inhibited HRas(INDUCES) 21209314; 27137893 2 4 5 +TGM2 TGM2 EC 2.3.2.13; KINASE; Transferase P21980 7052 20q11.23 human S215-p 467222 GRDCSRRsSPVYVGR molecular association, regulation 14-3-3 epsilon(INDUCES) 16870138 1 1 0 +LIG1 LIG1 DNA repair, damage; EC 6.5.1.1; Ligase P18858 3978 19q13.33 human K795-m1 58123203 EELQAICkLGTGFSD DNA_ligase_A_C molecular association, regulation L3MBTL iso4(INDUCES) 23583077 0 1 0 +TDP1 TDP1 DNA repair, damage; EC 3.1.4.-; Phosphodiesterase Q9NUW8 55775 14q32.11 human S81-p 11279401 PKRQKSGsQEDLGWC protein stabilization; molecular association, regulation; intracellular localization; protein conformation XRCC1(INDUCES); LIG3(INDUCES) 19851285; 20009512; 34181949 4 2 0 +TTK TTK Cancer Testis Antigen (CTA); EC 2.7.12.1; KINASE; Kinase, protein; Protein kinase, Other; Protein kinase, dual-specificity (non-receptor) P33981 7272 6q14.1 human S582-p 4145513 LNKLQQHsDKIIRLY Pkinase enzymatic activity, induced 18680479 1 0 0 in vitro +Kcnk18 KCNK18 Channel, ligand-gated; Channel, potassium; Membrane protein, integral; Membrane protein, multi-pass Q6VV64 332396 19|19 D3 mouse S276-p 12525800 VLGRLSCsILSNLDE activity, induced; protein conformation; activity, inhibited 14981085; 20215114; 22145024; 29763475; 32641496 8 0 0 +STIL STIL Cell cycle regulation; Cell development/differentiation; Oncoprotein Q15468 6491 1p33 human S1116-p 17400758 LISPNNMsFATKKYM molecular association, regulation; intracellular localization cell cycle regulation; cytoskeletal reorganization SAS6(INDUCES) 26101219; 31115335 3 2 0 +Cdh5 CDH5 Cell adhesion; Membrane protein, integral; Motility/polarity/chemotaxis P55284 12562 8 D3|8 53.04 cM mouse Y685-p 455658 MDARPAVyTQVQKPP receptor internalization, induced; molecular association, regulation; phosphorylation endocytosis, induced; cell growth, altered CSK(INDUCES) 15861137; 33550461; 37237266 18 4 145 decreases vessel maturation +Ulk1 ULK1 Autophagy; EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, Other; Protein kinase, Ser/Thr (non-receptor) O70405 22241 5|5 F mouse T754-gl 231166706 SPAPVVFtVGSPPSG molecular association, regulation AMPKA1(INDUCES) 28903979 2 0 0 +RECQL4 RECQL4 EC 3.6.4.12; Helicase O94761 9401 8q24.3 human T93-p 40722275 ATKSPQStPGRSRQG Drc1-Sld2 molecular association, regulation WDHD1(INDUCES); GINS4(INDUCES) 31519754 1 3 0 induces activation of replication origin +mos MOS EC 2.7.11.1; KINASE; Kinase, protein; Oncoprotein; Protein kinase, Other; Protein kinase, Ser/Thr (non-receptor) P12965 397924 frog S105-p 466947 NSLASRQsFWAELNA Pkinase enzymatic activity, inhibited 16809767 1 1 0 dephosphorylation of S105 is necessary for the mitotic activation of Mos +Camk1d CAMK1D EC 2.7.11.17; KINASE; Kinase, protein; Protein kinase, CAMK; Protein kinase, Ser/Thr (non-receptor) Q8BW96 227541 2|2 A1 mouse T180-p 450469 GKGDVMStACGTPGY Pkinase enzymatic activity, induced 33417706 2 5 15 +FUS hnRNP P2 DNA-binding; Nuclear receptor co-regulator; Oncoprotein; RNA splicing; RNA-binding; SUMO LIGASE P35637 2521 16p11.2 human Y526-p 50318713 QDRRERPy_______ molecular association, regulation; intracellular localization KPNB2(DISRUPTS) 26403203; 37071594 2 0 0 +ANKRD28 ANKRD28 Protein phosphatase, regulatory subunit O15084 23243 3p25.1 human S1007-p 459224 INRYTNTsKTVSFEA intracellular localization transcription, inhibited PPP1CA(DISRUPTS) 16564677; 17023142 2 1 0 +Rcan1 RCAN1 Inhibitor Q9JHG6 54720 16 C4|16 53.6 cM mouse S161-p 456022 PDKQFLIsPPASPPV Calcipressin molecular association, regulation PPP3CA(DISRUPTS) 22864830 7 34 5 +Trhr TRHR GPCR, family 1; Membrane protein, integral; Membrane protein, multi-pass; Receptor, GPCR Q01717 25570 7q31 rat T365-p 465592 KESDRFStELDDITV intracellular localization; receptor internalization, altered 11278484; 17329249; 17989235; 20345371 5 0 0 +YWHAB 14-3-3 beta Adaptor/scaffold P31946 7529 20q13.12 human S186-p 449845 FYYEILNsPEKACSL 14-3-3 molecular association, regulation Abl iso2(DISRUPTS) 15696159 3 5 0 +MDM2 MDM2 EC 6.3.2.-; EC 6.3.2.19; Inhibitor; Ligase; NEDDYLATION LIGASE; Neddylation Ligase; Nucleolus; Oncoprotein; UBIQUITIN LIGASE; Ubiquitin conjugating system; Ubiquitin ligase Q00987 4193 12q15 human S121-p 15714602 ESSDSGTsVSENRCH protein degradation; molecular association, regulation; ubiquitination FBW1B(INDUCES) 20708156 2 1 0 +G6PD G6PD Carbohydrate Metabolism - pentose phosphate pathway; Cell development/differentiation; EC 1.1.1.49; Other Amino Acids Metabolism - glutathione; Oxidoreductase P11413 2539 Xq28 human Y503-p 454849 MKRVGFQyEGTYKWV G6PD_C protein degradation; molecular association, regulation; enzymatic activity, inhibited; protein conformation apoptosis, induced p53(INDUCES); G6PD(DISRUPTS) 37798264 1 28 962 induction of apoptotic signaling; negatively regulates dimerization; reshaped the dimer interface and propagated to the substrate binding +KIF20A KIF20A Microtubule-binding; Motor O95235 10112 5q31.2 human S244-p 459830 LSTSLKRsVYIESRI Kinesin intracellular localization; activity, inhibited chromatin organization, altered 28630147 1 5 0 inhibits microtubule bundling activity but not microtubule binding +Guk1 GUK1 EC 2.7.4.8; KINASE; Kinase, other; Nucleotide Metabolism - purine Q64520 14923 11|11 B1.3 mouse S37-p 7493500 SIFGFSVsHTTRNPR Guanylate_kin enzymatic activity, induced cell growth, altered 19136674 1 0 0 Mutants display a drug resistance phenotype to 6-GT and decreased enzymatic activity. +STK3 MST2 Autophagy; EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, STE; Protein kinase, Ser/Thr (non-receptor) Q13188 6788 8q22.2 human S316-p 468210 LEEEEENsDEDELDS molecular association, regulation; ubiquitination; intracellular localization; phosphorylation cell cycle regulation; carcinogenesis, induced NEK2(DISRUPTS) 21723128; 37739411 2 57 12 TRIM69 regulates centrosome dynamics and mitotic progression and centrosome amplification, regulates centrosome clustering, promotes triple-negative breast cancer; TRIM69A regulates MST2 ubiquitination and intracellular localization +HNRNPA2B1 hnRNP A2/B1 iso2 RNA splicing; RNA-binding; Spliceosome P22626-2 3181 7p15.2 human K174-ub 1877221604 GHNAEVRkALSRQEM protein degradation carcinogenesis, inhibited; cell growth, inhibited 32826868 1 0 0 +MERTK Mer EC 2.7.10.1; KINASE; Kinase, protein; Membrane protein, integral; Oncoprotein; Protein kinase, TK; Protein kinase, tyrosine (receptor) Q12866 10461 2q13 human Y753-p 449989 KKIYSGDyYRQGRIA PK_Tyr_Ser-Thr enzymatic activity, induced 8702477 1 15 396 +SIGLEC9 Siglec-9 Membrane protein, integral; Receptor, misc. Q9Y336 27180 19q13.41 human Y433-p 464275 VGEGELQyASLSFQM transcription, inhibited; signaling pathway regulation 33431669 1 0 1 inhibits TLR4 signaling +Hnrnpf hnRNP F RNA splicing; RNA-binding; Spliceosome Q794E4 64200 4q42 rat K87-ub 12245479 HRYIEVFkSHRTEMD protein stabilization RNA splicing, induced 25959059 1 8 21 +NCOR2 SMRT Nuclear receptor co-regulator; Transcription, coactivator/corepressor Q9Y618 9612 12q24.31 human T1383-p 3217644 KLLKREGtPPPPPPS intracellular localization signaling pathway regulation 26778753 1 46 27 inhibits Wnt/beta-catenin signaling in HCC +MYH9 MYH9 Actin-binding; Motility/polarity/chemotaxis; Motor P35579 4627 22q12.3 human T1800-p 2482302 KLQEMEGtVKSKYKA Myosin_tail_1 intracellular localization cytoskeletal reorganization 18394644 1 1 1 +H3C1 H3 DNA-binding P68431 8350 6p22.2 human K79-me 1458617 REIAQDFkTDLRFQS Histone molecular association, regulation 53BP1(INDUCES) 15525939 8 2 0 +H3C1 H3 DNA-binding P68431 8350 6p22.2 human K4-me 1668802 ____ARTkQTARKST Histone molecular association, regulation; acetylation; intracellular localization; methylation carcinogenesis, induced; cell motility, induced; cell growth, induced; cell differentiation, induced; chromatin organization, altered; transcription, induced; transcription, altered CHD-7(INDUCES); HDAC1(DISRUPTS); MTA2(DISRUPTS); HP1 alpha(DISRUPTS) DNA(INDUCES) 11779497; 11850410; 12482974; 17391001; 18628788; 19251738; 19377461; 20829218; 20959362; 23772023; 27572339; 27716482 29 1 0 epithelial-mesenchymal transition (EMT), facilitated the H3K4me demethylation; promotes H3K4 methylation; decreases H3K27 trimethylation +ARRB2 ARRB2 iso2 Adaptor/scaffold P32120-2 281638 cow T382-p 455373 EFETNYAtDDDIVFE molecular association, regulation TRPV1(DISRUPTS) 23360390 5 3 2 +PLCB3 PLCB3 Carbohydrate Metabolism - inositol phosphate; EC 3.1.4.11; Phospholipase Q01970 5331 11q13.1 human S1105-p 448448 LDRKRHNsISEAKMR PLC-beta_C enzymatic activity, inhibited 9660757 5 22 216 +Cdh1 CDH1 Cell adhesion; Membrane protein, integral; Motility/polarity/chemotaxis; UBIQUITIN LIGASE; Ubiquitin ligase P09803 12550 8 D3|8 53.18 cM mouse S848-p 15754601 GSEAASLsSLNSSES CADH_Y-type_LIR molecular association, regulation CTNNB1(INDUCES) 11348595 1 1 0 +Cd79a Ig-alpha Immunoglobulin superfamily; Membrane protein, integral P11911 12518 7 A3|7 13.49 cM mouse Y193-p 473329 NLDDCSMyEDISRGL ITAM activity, induced; molecular association, regulation; phosphorylation cell differentiation, altered; signaling pathway regulation Syk(INDUCES) 11859098; 11909947; 17163454; 9531288 4 1 25 Ca(2+) signaling +ACKR3 CMKOR1 GPCR, family 1; Membrane protein, integral; Membrane protein, multi-pass; Receptor, GPCR P25106 57007 2q37.3 human T352-p 4709314 DASRVSEtEYSALEQ receptor internalization, induced; molecular association, regulation; intracellular localization ARRB1(INDUCES) 33799570 2 3 0 +HIF1A HIF1A Autophagy; DNA-binding; Transcription factor Q16665 3091 14q23.2 human S31-p 56589706 DAARSRRsKESEVFY molecular association, regulation; activity, inhibited transcription, inhibited DNA(DISRUPTS) 34285132 2 1 0 +PYCR1 PYCR1 Amino Acid Metabolism - arginine and proline; EC 1.5.1.2; Mitochondrial; Oxidoreductase P32322 5831 17q25.3 human K228-ac 1878196105 EQHPGQLkDNVSSPG enzymatic activity, inhibited cell growth, inhibited PYCR1(INDUCES) 31108370 1 0 0 Acetylation of K228 impairs the formation of decamers and inhibits enzymatic activity +SLC14A2 SLC14A2 Membrane protein, integral; Membrane protein, multi-pass; Transporter; Transporter, SLC family Q15849 8170 18q12.3 human S477-p 2813501 AVLSKHRsVFHIEWS ubiquitination 24133116 10 2 3 mutant reduces forskolin induced SLC14AZ ubiquitination +Vangl2 VANGL2 Adaptor/scaffold; Membrane protein, integral; Membrane protein, multi-pass Q91ZD4 93840 1 H3|1 79.54 cM mouse S5-p 18460402 ___MDTEsQYSGYSY activity, induced; protein stabilization 21316585 1 0 0 +STK11 LKB1 Autophagy; EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, CAMK; Protein kinase, Ser/Thr (non-receptor); Tumor suppressor Q15831 6794 19p13.3 human S307-p 7710000 IRQIRQHsWFRKKHP Pkinase molecular association, regulation; intracellular localization apoptosis, altered; cell growth, altered Exportin-1(INDUCES); AMPKA1(INDUCES); STRAD(INDUCES) 19414597 2 0 0 in the presence of ONOO(-); supresses angiogenesis +HDAC3 HDAC3 Apoptosis; Cell cycle regulation; DEACETYLASE; Deacetylase; EC 3.5.1.98; Nuclear receptor co-regulator; Transcription, coactivator/corepressor O15379 8841 5q31.3 human Y298-p 1884166702 LVLGGGGyTVRNVAR carcinogenesis, induced; cell motility, induced; transcription, induced 34973135 1 0 0 +Ppp1r12a MYPT1 Motility/polarity/chemotaxis; PHOSPHATASE; Protein phosphatase, regulatory subunit Q9DBR7 17931 10 D1|10 56.33 cM mouse K442-m1 1872438900 SWRLGLRkTGSYGAL protein stabilization 21115810 1 0 0 +Stxbp5l STXBP5L Q5DQR4 207227 16 26.32 cM|16 B3 mouse K279-sm 31957312 SLTLWNLkSPSRPFQ neural plasticity 24614299 1 0 0 +SKAP1 SKAP55 Adaptor/scaffold; Motility/polarity/chemotaxis Q86WV1 8631 17q21.32 human Y219-p 451307 LSSLTIPyEEDEEEE molecular association, regulation CD45(INDUCES) 11909961 1 0 0 +Syn1 SYN1 Vesicle O88935 20964 X A1.3|X 16.37 cM mouse S9-p 448378 NYLRRRLsDSNFMAN Synapsin_N molecular association, regulation neural plasticity; signaling pathway regulation ACTB(DISRUPTS) 28698220; 31242289 25 5 2 intersynaptic vesicular trafficking; plays an important role in the developming visual cortex in mice +MARK2 MARK2 EC 2.7.11.1; EC 2.7.11.26; KINASE; Kinase, protein; Protein kinase, CAMK; Protein kinase, Ser/Thr (non-receptor) Q7KZI7 2011 11q13.1 human S212-p 450068 KLDTFCGsPPYAAPE Pkinase enzymatic activity, inhibited cell differentiation, altered; cytoskeletal reorganization 18424437 6 12 11 GSK3B coexpression inhibits MARK2 enzymatic activity. +NPM/ALK NPM-ALK KINASE; Kinase, protein; Protein kinase, TK; Protein kinase, tyrosine (receptor) AAA58698 human S164-p 27275103 CFAGKTSsISDLKEV phosphorylation carcinogenesis, altered; cell growth, altered 21045017 1 1 0 +HBP1 HBP1 DNA-binding; Transcription factor O60381 26959 7q22.3 human K419-ac 25171019 SLYAKAVkNHSSGTV molecular association, regulation cell cycle regulation; transcription, induced; transcription, inhibited DNA(INDUCES) 21967847; 23249948 2 0 0 acetylation of the five sites induces transcriptional repression of the DNMT1 gene, regulates cellular senescence +NFKB1 NFkB-p105 DNA-binding; Transcription factor P19838 4790 4q24 human S932-p 447771 CDSGVETsFRKLSFT protein degradation 10469655; 12482991 6 0 0 +Nr1h4 NR1H4 DNA-binding; Nuclear receptor Q60641 20186 10 C2|10 44.98 cM mouse Y77-p 1186568001 QISSSSYySNLGFYP transcription, induced 30996006 2 1 0 protection of mice from arthrosclerosis; increased mRNA expression levels of Scarb1 and Abcg1/5/8; maintains Cholestrol homeostasis (lowering cholestrol levels) +Dlg4 PSD-95 Adaptor/scaffold P31016 29495 10q24 rat S561-p 25680400 EFPDKFGsCVPHTTR Guanylate_kin protein conformation PSD-95(INDUCES) 28790172 2 1 0 GK domain forms an intramolecular interaction with the adjacent SH3 domain, spine structural plasticity +SLK SLK EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, STE; Protein kinase, Ser/Thr (non-receptor) Q9H2G2 9748 10q24.33-q25.1 human S189-p 468769 RTIQRRDsFIGTPYW Pkinase molecular association, regulation; phosphorylation; enzymatic activity, induced apoptosis, induced SLK(INDUCES) 22203681; 28475647 2 45 305 induces phosphorylation of JNK and p38, homodimerization induces kinase activity +ADAM22 ADAM22 Cell adhesion; Membrane protein, integral; Motility/polarity/chemotaxis Q9P0K1 53616 7q21.12 human S834-p 469108 NGRPRSNsWQGNLGG protein stabilization; molecular association, regulation; intracellular localization 14-3-3 beta(INDUCES); 14-3-3 theta(INDUCES); 14-3-3 zeta(INDUCES); 14-3-3 epsilon(INDUCES); 14-3-3 gamma(INDUCES); 14-3-3 eta(INDUCES) 16868027 2 24 97 +MAP2K4 MKK4 EC 2.7.12.2; KINASE; Kinase, protein; Protein kinase, STE; Protein kinase, dual-specificity (non-receptor) P45985 6416 17p12 human T261-p 447656 LVDSIAKtRDAGCRP Pkinase enzymatic activity, induced cell cycle regulation; carcinogenesis, induced; cell growth, induced; transcription, induced 10727406; 15328343; 35843311; 9162092 26 3 1 +SPOP SPOP UBIQUITIN LIGASE; Ubiquitin ligase O43791 8405 17q21.33 human S6-p 36136244 __MSRVPsPPPPAEM protein stabilization; molecular association, regulation FZR1(DISRUPTS); 14-3-3 gamma(INDUCES) 29160310 1 4 0 +NEDD1 NEDD1 Cell cycle regulation Q8NHV4 121441 12q23.1 human S566-p 25533016 VTAGVASsLSEKIAD molecular association, regulation cytoskeletal reorganization TUBG1(INDUCES) 22595525 1 1 0 Promote NEDD1 activity; regulates spindle assembly in mitosis +NCF1 p47phox EC 1.-.-.-; Oxidoreductase P14598 653361 7q11.23 human S359-p 451729 EERQTQRsKPQPAVP p47_phox_C activity, induced; molecular association, regulation; intracellular localization; enzymatic activity, induced; phosphorylation CYBA(INDUCES) 12056906; 9857051 12 0 0 +Ubtf UBF DNA-binding; Nucleolus; Transcription factor P25976 21429 11|11 D mouse S389-p 450170 INKKQTTsPASKKPS transcription, altered 11698641 4 3 1 +Zc3h12a MCPIP1 EC 3.1.-.-; Hydrolase Q5D1E7 230738 4|4 D2.2 mouse S494-p 56659543 AMGAGHFsVPTDYVP protein stabilization; molecular association, regulation; intracellular localization RNA stability, induced 14-3-3 beta(INDUCES); MCPIP1(DISRUPTS) RNA(DISRUPTS) 31072819; 34636324 2 2 0 +RXRA RXRA DNA-binding; Motility/polarity/chemotaxis; Nuclear receptor P19793 6256 9q34.2 human S78-p 333674902 PMGPHSMsVPTTPTL Nuc_recep-AF1 ubiquitination carcinogenesis, induced; transcription, induced; signaling pathway regulation 29137318; 30518934 2 0 0 PI3K/AKT signaling ; PIK3CA transcription; negatively regulated beta-catenin expression by ubiquitination of ?-catenin in CRC +PAN2 USP52 DEUBIQUITINASE; EC 3.1.13.4; Ribonuclease; Ubiquitin-specific protease Q504Q3 9924 12q13.3 human S1003-p 50792538 TKSTIKPsQMSVARI RNase_T molecular association, regulation; ubiquitination; enzymatic activity, induced DNA repair, induced POLR1B(INDUCES); RAD51(INDUCES) 33097710 1 1 0 Increase deubiquitination/regulates CtIP deubiquitination +THRA TR-alpha DNA-binding; Nuclear receptor; Transcription factor NP_990644 396251 chicken K132-ac 10769109 DDSKRVAkRKLIEEN molecular association, regulation carcinogenesis, inhibited; transcription, altered SMRT(DISRUPTS); ACTR1A(INDUCES) DNA(INDUCES) 19819978 1 0 0 induces transactivation and transrepression of transcription +Ensa ENSA Inhibitor; Protein phosphatase, regulatory subunit P60840 56205 3|3 F2.1 mouse S67-p 455934 KGQKYFDsGDYNMAK Endosulfine cell cycle regulation; signaling pathway regulation 30293837 5 68 47 part of MASTL-ENSA-PP2A pathway +PRKAB1 AMPKB1 Autophagy; KINASE; Protein kinase, regulatory subunit Q9Y478 5564 12q24.23 human T148-p 7447514 IVTSQLGtVNNIIQV AMPK1_CBM molecular association, regulation Other(DISRUPTS) 25792737 1 2 1 loss of carbohydrate binding ability, 148D mutant prevents binding to cellular glycogen +Sox9 SOX9 DNA-binding; Transcription factor F1LYL9 140586 rat K62-ac 1881321501 KGEPDLKkESEEDKF intracellular localization cell growth, induced; transcription, induced 34156114 1 1 0 Binding of SOX9 to FGF1 or PDGF-alpha promoter +PARP1 PARP1 DNA repair, damage; EC 2.4.2.30; Nuclear envelope; Nuclear receptor co-regulator; Nucleolus; Transferase P09874 142 1q42.12 human S785-p 21440500 LRGGSDDsSKDPIDV PARP_reg intracellular localization; enzymatic activity, inhibited; enzymatic activity, induced 21922195; 25069723 2 2 0 Non-apoptotic cell death induced +ACADVL ACADVL EC 1.3.8.9; Lipid Metabolism - fatty acid; Mitochondrial; Oxidoreductase P49748 37 17p13.1 human S586-p 22680600 VVVLSRAsRSLSEGH enzymatic activity, induced cell growth, induced; apoptosis, inhibited 19889959 1 1 0 +ACTB ACTB Cytoskeletal; Motility/polarity/chemotaxis P60709 60 7p22.1 human K68-sm 9859926 KRGILTLkYPIEHGI Actin intracellular localization 19635839 1 0 0 nuclear localization +SCN5A SCN5A Channel, sodium; Membrane protein, integral; Membrane protein, multi-pass Q14524 6331 3p22.2 human S671-p 1871776501 SAVSVLTsALEELEE intracellular localization; protein conformation; activity, inhibited 33410863 1 1 0 +Dnm1 DYN1 EC 3.6.5.5; Hydrolase; Microtubule-binding; Motility/polarity/chemotaxis; Motor; Vesicle P21575 140694 3p12 rat S778-p 450206 GRRSPTSsPTPQRRA molecular association, regulation endocytosis, altered endophilin A1(INDUCES); PACSIN1(INDUCES); PACSIN1(DISRUPTS) 16648848; 17437541 14 24 6 regulates synaptic vesicle endocytosis; interaction essential for synaptic vesicle endocytosis +Mybpc3 MYBPC3 Myosin-binding O70468 17868 2|2 E1 mouse S273-p 471079 RSAFRRTsLAGAGRR activity, induced; molecular association, regulation; intracellular localization; protein conformation apoptosis, altered; cytoskeletal reorganization MYBPC1(DISRUPTS) 17075052; 21978630; 22752314; 24951619; 25740838; 26908877; 28167762 25 9 14 phosphorylation weakens this stabilization and binding of the heads to the backbone, increasing the probability of their interacting with the thin filament +CKMT2 CKMT2 Amino Acid Metabolism - arginine and proline; EC 2.7.3.2; Kinase, other; Mitochondrial P17540 1160 5q14.1 human Y255-p 1914505 ARGIWHNyDKTFLIW ATP-gua_Ptrans enzymatic activity, induced transcription, induced; signaling pathway regulation 34095014 1 2 41 induces PGC-1a/estrogen-related receptor-a pathway +OLA1 OLA1 EC 3.6.3.-; Hydrolase; Nucleolus Q9NTK5 29789 2q31.1 human T124-p 1883583904 CDGIFHLtRAFEDDD protein degradation; molecular association, regulation; ubiquitination; intracellular localization AurA(INDUCES) 37481721 1 0 0 +TFAM TFAM DNA-binding; Transcription regulation Q00059 7019 10q21.1 human K69-ac 1876567504 KEQLPIFkAQNPDAK HMG_box transcription, induced 35278431 0 1 0 +RANGAP1 RANGAP1 GAP; GAP, Ras P46060 5905 22q13.2 human S506-p 1873645606 QKAFNSSsFNSNTFL RanGAP1_C sumoylation; intracellular localization 34110283 1 0 0 WT RANGAP1 rescues nuclear import of NF-ATc1, NF-kB, AP-1 in RanGAP1 (KD), required in various nuclear transport pathways +PIGR PIGR Immunoglobulin superfamily; Membrane protein, integral; Receptor, misc. P01832 100328593 rabbit S744-p 451444 PKKAKRSsKEEADLA intracellular localization 8343953 1 5 0 Mutation of S744 drastically reduces transcytosys of dIgA. +Akt1 Akt1 EC 2.7.11.1; KINASE; Kinase, protein; Oncoprotein; Protein kinase, AGC; Protein kinase, Ser/Thr (non-receptor) P47196 24185 6q32 rat T34-p 455493 FLLKNDGtFIGYKER PH enzymatic activity, inhibited 14560023 2 1 1 +Kcnab2 Kv-beta2 Channel, potassium P62483 29738 5q36 rat S9-p 486012 YPESTTGsPARLSLR activity, induced; molecular association, regulation; intracellular localization EB1(DISRUPTS) 21357749 2 20 7 +RAD9A RAD9A Apoptosis; Cell cycle regulation; DNA replication; Deoxyribonuclease; EC 3.1.11.2 Q99638 5883 11q13.2 human S272-p 447824 LSDTDSHsQDLGSPE activity, induced; ubiquitination cell cycle regulation; DNA repair, induced 11278446; 22453082; 26658951 7 5 7 controls repair pathways, maintenance of replication fork stability +Nfasc neurofascin Membrane protein, integral; Motility/polarity/chemotaxis P97685 116690 13q13 rat Y1212-p 452190 DGSFIGQyTVRKDKE Bravo_FIGEY molecular association, regulation ANK1(DISRUPTS) 9151675 1 0 0 +Nr3c1 GR DNA-binding; Mitochondrial; Nuclear receptor; Transcription factor P06536 24413 18p11 rat S232-p 447968 PSKDTNEsPWRSDLL GCR activity, induced; intracellular localization transcription, altered 18304804; 25330740 51 5 0 induces hormone-dependent recruitment of GR to promoters (of tat, sult and gliz genes) +TH TH iso3 Amino Acid Metabolism - tyrosine; EC 1.14.16.2; Endoplasmic reticulum; Mitochondrial; Oxidoreductase; Vesicle P07101-3 7054 11p15.5 human S40-p 448545 RFIGRRQsLIEDARK TOH_N enzymatic activity, induced 12421349; 33456492; 7901013; 9920892 62 11 11 absence of S31 and S40 in an alternative spliced variant lacking exon 3 that has reduced enzymatic activity in vitro +Ndel1 NDEL1 Microtubule-binding; Protease Q9ERR1 83431 11|11 B3 mouse T245-p 3211851 GFGTSPLtPSARISA NUDE_C activity, induced; intracellular localization cell motility, altered 18331715 2 7 3 Cdc42 activation +Cycs CYCS Apoptosis; Mitochondrial; Oxidoreductase; PHOSPHATASE; Protein phosphatase, Ser/Thr (non-receptor) P62897 13063 6 B2.3|6 24.32 cM mouse T50-p 8086210 QAAGFSYtDANKNKG Cytochrom_C apoptosis, inhibited 35896004 1 2 1 +ETV1 ETV1 DNA-binding; Oncoprotein; Transcription factor P50549 2115 7p21.2 human T139-p 3059605 MRPSNPPtPSSTPVS ETS_PEA3_N activity, induced transcription, induced 12213813 2 0 0 +MDM2 MDM2 EC 6.3.2.-; EC 6.3.2.19; Inhibitor; Ligase; NEDDYLATION LIGASE; Neddylation Ligase; Nucleolus; Oncoprotein; UBIQUITIN LIGASE; Ubiquitin conjugating system; Ubiquitin ligase Q00987 4193 12q15 human S240-p 454919 GDWLDQDsVSDQFSV activity, induced 12167711 3 1 0 promotes p53 degradation +PDGFRB PDGFRB EC 2.7.10.1; KINASE; Kinase, protein; Membrane protein, integral; Oncoprotein; Protein kinase, TK; Protein kinase, tyrosine (receptor) P09619 5159 5q32 human Y716-p 447524 RPPSAELySNALPVG PK_Tyr_Ser-Thr activity, induced; molecular association, regulation GRB2(INDUCES); GRB7(INDUCES) 7935391; 8940081 5 1 2 +MRPL10 MRPL10 Mitochondrial; Ribosomal; Translation Q3MHY7 515014 cow K46-ac 12674400 VMHFERQkLMAVTEY translation, induced 20042612 1 1 0 downregulates protein synthesis +Jak2 JAK2 EC 2.7.10.2; KINASE; Kinase, protein; Oncoprotein; Protein kinase, TK; Protein kinase, tyrosine (non-receptor) Q62120 16452 19 C1|19 23.73 cM mouse S633-p 1880516404 QEFVKFGsLDTYLKK activity, inhibited carcinogenesis, induced; transcription, inhibited; signaling pathway regulation 36356831 1 0 0 regulates JAK2/STAT5 signaling pathway +SIRT2 SIRT2 DEACETYLASE; Deacetylase; EC 3.5.1.- Q8IXJ6 22933 19q13.2 human S368-p 482809 PNPSTSAsPKKSPPP enzymatic activity, inhibited cell motility, altered; cell adhesion, altered; cell growth, altered 17488717; 18332217 7 31 0 hyperphosphorylated during mitotic arrest; ; delay in cell growth of S368E mutant was observed; cell cycle-regulated phosphorylation +TP53BP1 53BP1 DNA repair, damage; Transcription, coactivator/corepressor Q12888 7158 15q15.3 human R1398-me 2344819 APVTPRGrGRRGRPP molecular association, regulation DNA(INDUCES) 16294045 2 0 0 +DAPP1 DAPP1 Adaptor/scaffold Q9UN19 27071 4q23 human Y139-p 448325 KVEEPSIyESVRVHT activity, induced; molecular association, regulation; intracellular localization; phosphorylation carcinogenesis, inhibited; cytoskeletal reorganization; signaling pathway regulation SH2D1B(NOT_REPORTED); PLCG2(INDUCES) 10770799; 11102801; 15247305; 22981863; 23322602; 30131370 7 17 324 +Rb1 Rb Nuclear receptor co-regulator; Oncoprotein; Transcription, coactivator/corepressor; Tumor suppressor P13405 19645 14 38.73 cM|14 D3 mouse T364-p 450023 DEEANVVtPHTPVRT molecular association, regulation E2F1(DISRUPTS) 10207050 1 6 0 +Sv2a SV2A Membrane protein, integral; Membrane protein, multi-pass; Vesicle Q9JIS5 64051 3|3 F2.1 mouse T84-p 4779764 GGASSDAtEGHDEDD molecular association, regulation SYT1(INDUCES) 25673844 1 9 10 SV2A retrieval during SV endocytosis, Thr84 of SV2A is critical in promoting the interaction with synaptotagmin-1 +Cldn16 Claudin-16 Cell adhesion; Membrane protein, integral; Membrane protein, multi-pass Q91Y55 155268 11q22 rat T225-p 11555105 YKAPRTEtAKMYAVD intracellular localization 19914201 1 0 0 +Ezr Ezrin Cytoskeletal; Motility/polarity/chemotaxis P31977 54319 1q11 rat T567-p 448104 QGRDKYKtLRQIRQG ERM_C intracellular localization cytoskeletal reorganization 16938849; 34054551 68 9 16 regulates endothelial hyperpermeability +Cul5 CUL5 UBIQUITIN LIGASE; Ubiquitin conjugating system; Ubiquitin ligase Q9JJ31 64624 8q24 rat S730-p 963800 MKMRKKIsNAQLQTE Cullin_Nedd8 cytoskeletal reorganization; cell growth, altered 17950367 5 0 0 S730 phosphorylation may regulate angiogenisis. +WRN WRN Cell cycle regulation; DNA repair, damage; DNA-binding; EC 3.6.4.12; Helicase; Nucleolus Q14191 7486 8p12 human S426-p 3196115 YKSTEHLsPNDNEND molecular association, regulation; intracellular localization DNA repair, altered RPA1(INDUCES) 34612580 1 10 0 +MAP3K11 MLK3 EC 2.7.11.25; KINASE; Kinase, protein; Protein kinase, Ser/Thr (non-receptor); Protein kinase, TKL Q16584 4296 11q13.1 human S793-p 448613 PRPSPLPsPQPAPRR enzymatic activity, induced apoptosis, induced 17711861 2 21 6 induces activation of itself and JNK +Khdrbs1 KHDRBS1 RNA-binding Q60749 20218 4|4 D2.2 mouse T84-p 449878 TVVGSAPtPLLPPSA activity, induced translation, altered 12478298 1 2 5 regulates splicing +Rnf10 RNF10 Ubiquitin conjugating system Q3UIW5 50849 5 F|5 56.01 cM mouse S31-p 1868450200 SSASSGSsKGQQPPR molecular association, regulation; intracellular localization neural plasticity; signaling pathway regulation NMDAR2A(DISRUPTS) 31069631 1 0 0 CREB signaling +TEK TIE2 EC 2.7.10.1; KINASE; Kinase, protein; Membrane protein, integral; Protein kinase, TK; Protein kinase, tyrosine (receptor) Q02763 7010 9p21.2 human S1119-p 453441 TYAGIDCsAEEAA__ activity, induced; enzymatic activity, induced 25320242 2 3 0 personal communication from Dr Chris Kontos , Duke University; activation promoted tight-junction stabilization and endothelial barrier protective effects +Nfatc2 NFAT1 DNA-binding; Transcription factor Q60591 18019 2 H3|2 88.91 cM mouse S365-p 449627 EQEERRNsAPESILL transcription, inhibited 11030334 0 13 6 +TP53 p53 Activator; DNA-binding; Motility/polarity/chemotaxis; Nuclear receptor co-regulator; Transcription factor; Tumor suppressor P04637 7157 17p13.1 human S315-p 447530 LPNNTSSsPQPKKKP activity, induced; protein degradation; molecular association, regulation; ubiquitination; intracellular localization; protein conformation; activity, inhibited cell cycle regulation; carcinogenesis, induced; apoptosis, altered; cell motility, induced; apoptosis, induced; cell motility, inhibited; transcription, induced; transcription, altered; cell growth, induced; apoptosis, inhibited; cell motility, altered; transcription, inhibited; cell growth, altered PIN1(INDUCES); NFkB-p100(DISRUPTS); p53(DISRUPTS) DNA(INDUCES); DNA(DISRUPTS) 11078726; 11687964; 12397361; 12397362; 14702041; 14744935; 15619621; 16037820; 16227590; 17906639; 18769132; 20661218; 20808790; 25691063; 26588988; 30266789; 33649292; 34798143; 35217309; 35393542; 36167685; 36371602; 7596441 49 32 7 +KLF3 KLF3 C2H2-type zinc finger protein; DNA-binding; Transcription factor P57682 51274 4p14 human K10-sm 3617604 MFDPVPVkQEAMDPV molecular association, regulation transcription, inhibited 15684403 1 1 0 +Gabbr2 GABBR2 GPCR, family 3; Membrane protein, integral; Membrane protein, multi-pass; Receptor, GPCR O88871 83633 5q22 rat S892-p 450809 EHIQRRLsLQLPILH activity, induced; protein stabilization 11976702; 14707142 6 1 0 +Esr1 ER-alpha DNA-binding; Nuclear receptor; Transcription factor P19785 13982 10 A1|10 2.03 cM mouse S122-p 448101 LHPPPQLsPFLHPHG Oest_recep transcription, altered 8541227 93 2 0 A reduction of basal transcriptional activity was observed when S122 was mutated. The effect of the replacement was increased by the introduction of mutations into AF-2 in the hormone binding domain. Optimum phosphorylation of S122 is dependent on the phosphorylation of S298. +BAK1 BAK1 Apoptosis; Endoplasmic reticulum; Membrane protein, integral; Mitochondrial Q16611 578 6p21.31 human S117-p 27276102 YFTKIATsLFESGIN Bcl-2 molecular association, regulation; protein conformation; activity, inhibited apoptosis, inhibited; signaling pathway regulation BAK1(DISRUPTS) 23189150 1 1 0 S117 dephosphorylation is required for BAK multimerization +PDCD5 PDCD5 Apoptosis O14737 9141 19q13.11 human S119-p 452536 NRRKVMDsDEDDDY_ protein degradation; protein stabilization; molecular association, regulation; ubiquitination; intracellular localization carcinogenesis, inhibited; apoptosis, induced; cell adhesion, altered IPO13(INDUCES) 19616514; 26077467; 28051100 3 75 262 +IGFBP1 IGFBP1 Secreted; Secreted, signal peptide P08833 3484 7p12.3 human S194-p 451660 LAKAQETsGEEISKF Thyroglobulin_1 activity, induced; molecular association, regulation; activity, inhibited; phosphorylation signaling pathway regulation IGF1(INDUCES); CK2B(INDUCES) 18772238; 20143870; 25957086; 32502935 15 15 0 regulates mTOR and AAR signaling; inhibits IGF-1RB autophosphorylation and activity +CNTROB LIP8 Cell cycle regulation Q8N137 116840 17p13.1 human S45-p 27565614 LYASLRLsRQAEATA cell motility, inhibited 23291182 1 0 0 +MAT1A MAT1A Amino Acid Metabolism - cysteine and methionine; EC 2.5.1.6; Other Amino Acids Metabolism - selenoamino acid; Transferase Q00266 4143 10q22.3 human S180-p 1874404502 LPWLRPDsKTQVTVQ S-AdoMet_synt_M protein degradation; molecular association, regulation; intracellular localization carcinogenesis, induced; cell motility, induced; cell growth, induced; transcription, induced 14-3-3 zeta(INDUCES) 34349244 1 0 0 +NDEL1 NDEL1 Microtubule-binding; Protease Q9GZM8 81565 17p13.1 human S198-p 474508 TRKSAPSsPTLDCEK NUDE_C molecular association, regulation; intracellular localization PAFAH1B1(INDUCES); DYNC1I1(INDUCES) 12556484; 37086789 4 25 0 +SIGIRR SIGIRR Membrane protein, integral; Receptor, misc. Q6IA17 59307 11p15.5 human T372-p 1873759800 EPSAPPHtSGVSLGE receptor internalization, induced; protein degradation; molecular association, regulation USP13(DISRUPTS) 33400290 1 0 0 +Stat1 STAT1 DNA-binding; Transcription factor P42225 20846 1 C1.1|1 26.81 cM mouse S727-p 447753 TDNLLPMsPEEFDEM STAT1_TAZ2bind activity, induced; sumoylation; protein degradation; molecular association, regulation; activity, inhibited; phosphorylation cell cycle regulation; cell growth, inhibited; cell motility, induced; apoptosis, induced; transcription, induced; signaling pathway regulation; transcription, altered; cell differentiation, induced; transcription, inhibited; cell growth, altered BTRC(INDUCES) DNA(INDUCES) 11226159; 12671680; 12748197; 14670297; 17255531; 17346795; 18378670; 18941537; 21636857; 23352233; 34124936; 34303919; 34560245; 34569651; 35394840; 37352855 118 32 90 +CDK5R2 CDK5R2 Protein kinase, regulatory subunit Q13319 8941 2q35 human T84-p 4697544 KKGSKKVtPKPASTG intracellular localization 22467861 1 4 0 CDK5R2 S8 in its unphosphorylated form accumulates at the perinuclear region and T84 plays a role in the nuclear localization of CDK5R2. +Arrb2 ARRB2 Adaptor/scaffold P29067 25388 10q24 rat T178-p 36120700 KVQFAPEtPGPQPSA receptor recycling, inhibited; protein stabilization signaling pathway regulation 25016018 1 0 0 stabilizes B2R/ARRB2 complexes, receptor recycling to plasma membrane is delayed +Spry1 SPRY1 Adaptor/scaffold; Inhibitor; Motility/polarity/chemotaxis Q9QXV9 24063 3|3 B mouse Y53-p 454589 AIRGSNEyTEGPSVA activity, induced signaling pathway regulation 22508938 3 18 234 +PML PML Nucleolus; Oncoprotein; SUMO LIGASE; SUMO conjugating system; SUMO ligase; Transcription factor; Tumor suppressor; Ubiquitin conjugating system P29590 5371 15q24.1 human S561-p 6835503 ERVVVISsSEDSDAE DUF3583 molecular association, regulation SUMO2(INDUCES); SUMO1(INDUCES); SUMO3(INDUCES) 19217413; 19380586 2 6 0 PML interaction with SUMO-modified protein partners and PML nuclear bodies maturation +Gch1 GCH1 Cofactor and Vitamin Metabolism - folate biosynthesis; EC 3.5.4.16; Hydrolase P22288 29244 15p14 rat T103-p 10428810 FTKGYQEtISDVLND GTP_cyclohydroI enzymatic activity, induced 19762783 1 0 0 +MFF MFF iso2 Membrane protein, integral; Mitochondrial Q9GZY8-2 56947 2q36.3 human K251-ub 41529300 SLRRQIIkLNRRLQL Miff molecular association, regulation autophagy, induced SQSTM1(INDUCES) 26008206 2 1 0 promotes p62/SQSTM1 recruitment during mitochondrial depolarization +Fkbp3 FKBP3 EC 5.2.1.8; Isomerase Q62446 30795 12|12 C1 mouse S163-p 4935796 KKNAKPLsFKVGVGK FKBP_C cell cycle regulation 33553183 1 6 6 +YY1 YY1 C2H2-type zinc finger protein; Cell development/differentiation; Transcription factor P25490 7528 14q32.2 human S365-p 15416769 EGCGKRFsLDFNLRT zf-C2H2 molecular association, regulation DNA(INDUCES) 28855673 2 5 3 overlaps but is not needed for the linker phosphorylation of YY1 +Add1 ADD1 Cytoskeletal; Motility/polarity/chemotaxis Q63028 24170 14q21 rat S714-p 449828 GSPGKSPsKKKKKFR intracellular localization cytoskeletal reorganization 9679146 5 1 0 +CUX1 CUTL1 DNA-binding; Membrane protein, integral; Transcription factor P39880 1523 7q22.1 human S1270-p 460701 YQQKPYPsPKTIEDL Homeodomain transcription, inhibited 16574653 1 16 0 +CLSPN claspin Actin-binding; Cell cycle regulation Q9HAW4 63967 1p34.3 human S945-p 455335 EELLNLCsGKFTSQD molecular association, regulation Chk1(INDUCES) 15707391 2 2 0 +PKM PKM Carbohydrate Metabolism - glycolysis and gluconeogenesis; Carbohydrate Metabolism - pyruvate; EC 2.7.1.40; KINASE; Kinase, other; Mitochondrial; Nucleotide Metabolism - purine P14618 5315 15q23 human T454-p 23132420 RAPIIAVtRNPQTAR PK_C protein stabilization; enzymatic activity, induced carcinogenesis, induced; cell growth, induced; transcription, induced 24142698 2 2 1 reduces mitochondrial respiration +Bad BAD Apoptosis Q61337 12015 19|19 A mouse S170-p 447864 KGLPRPKsAGTATQM Bcl-2_BAD cell cycle regulation; cell growth, inhibited; apoptosis, inhibited 11717309; 22103330 6 22 3 +SREBF1 SREBP-1 DNA-binding; Membrane protein, integral; Membrane protein, multi-pass; Transcription factor P36956 6720 17p11.2 human S434-p 6729302 PPPSDAGsPFQSSPL protein degradation; molecular association, regulation; activity, inhibited; phosphorylation FBXW7(INDUCES) 19126544 1 0 0 +Trip6 TRIP6 Adaptor/scaffold; Motility/polarity/chemotaxis; Nuclear receptor co-regulator Q9Z1Y4 22051 5|5 G2 mouse Y55-p 456050 PLPPEHCyQPPGVPE molecular association, regulation; intracellular localization cytoskeletal reorganization P130Cas(INDUCES); CRK(INDUCES) 15988003; 20547766 5 4 43 +HBP1 HBP1 DNA-binding; Transcription factor O60381 26959 7q22.3 human K307-ac 25171016 HPFYVKNkGWSSFYP AXH transcription, inhibited 23249948 2 0 0 acetylation of the five sites induces transcriptional repression of the DNMT1 gene, regulates cellular senescence +JUNB JunB Motility/polarity/chemotaxis; Oncoprotein; Transcription factor P17275 3726 19p13.13 human T102-p 1814001 SNGVITTtPTPPGQY Jun activity, induced; molecular association, regulation transcription, altered DNA(INDUCES) 9889198 1 4 0 Phosphorylation of JunB increases cooperative binding with c-Maf to DNA. +PKM PKM Carbohydrate Metabolism - glycolysis and gluconeogenesis; Carbohydrate Metabolism - pyruvate; EC 2.7.1.40; KINASE; Kinase, other; Mitochondrial; Nucleotide Metabolism - purine P14618 5315 15q23 human S222-p 27110046 AVDLPAVsEKDIQDL PK molecular association, regulation carcinogenesis, induced; DNA repair, induced SSRP1(INDUCES); SPT16(INDUCES) 35048565 1 7 0 binding to FACT complex regulates FACT binding to H2AX +EPOR EPOR Membrane protein, integral; Receptor, cytokine P19235 2057 19p13.2 human Y426-p 449884 ASAASFEyTILDPSS activity, induced; molecular association, regulation; activity, inhibited; phosphorylation cell cycle regulation; apoptosis, induced; apoptosis, inhibited; signaling pathway regulation; cell growth, altered STAT5A(INDUCES); SHIP(INDUCES); SOCS3(INDUCES); CISH(INDUCES) 10455108; 10660611; 11290583; 12027890; 12441334; 12506011; 14662339 10 0 0 +NUTM1 NUTM1 Unknown function Q86Y26 256646 15q14 human S1031-p 13165100 LASKLSLsPREHPLS NUT intracellular localization 17934517 1 0 0 nuclear-cytoplasmic shuttling +MAPKAPK5 MAPKAPK5 EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, CAMK; Protein kinase, Ser/Thr (non-receptor); Tumor suppressor Q8IW41 8550 12q24.12-q24.13 human S115-p 18704700 GELFHRIsQHRHFTE Pkinase intracellular localization cytoskeletal reorganization 20734105 2 0 0 S115D mutant causes F-actin rearrangments; S115A mutant reduced the ability of MAPKAPK5 to activate p53-mediated transcription +H2AX H2AX DNA repair, damage; DNA-binding; Helicase P16104 3014 11q23.3 human K36-ac 14791501 RVHRLLRkGHYAERV Histone DNA repair, induced 20488183 2 1 0 +SRC Src EC 2.7.10.2; KINASE; Kinase, protein; Oncoprotein; Protein kinase, TK; Protein kinase, tyrosine (non-receptor) P12931 6714 20q11.23 human S97-p 448232 VALYDYEsRTETDLS SH3_1 enzymatic activity, inhibited 1713455 1 0 0 +RCC2 TD-60 GEF; GEF, misc.; Nucleolus Q9P258 55920 1p36.13 human K293-m1 58123006 LGHNSDGkFIARAQR RCC1 molecular association, regulation L3MBTL iso4(INDUCES) 23583077 0 1 0 +PRC1 PRC1 Cell cycle regulation; Cytoskeletal; Microtubule-binding; Motility/polarity/chemotaxis O43663 9055 15q26.1 human T470-p 471795 LYGSAPRtPSKRRGL MAP65_ASE1 activity, induced; intracellular localization cell cycle regulation; cytoskeletal reorganization PRC1(INDUCES) 16603632; 17438553; 17512944; 27551054 4 12 54 recruitment to the anaphase spindle +CD274 PD-L1 Membrane protein, integral Q9NZQ7 29126 9p24.1 human K178-ub 1883389001 DHQVLSGkTTTTNSK ubiquitination 36376293 1 1 0 +CDC25B CDC25B EC 3.1.3.48; Motility/polarity/chemotaxis; Nuclear receptor co-regulator; PHOSPHATASE; Protein phosphatase, dual-specificity P30305 994 20p13 human S169-p 455885 VLRNITNsQAPDGRR M-inducer_phosp molecular association, regulation; enzymatic activity, induced 14-3-3 sigma(DISRUPTS); 14-3-3 beta(DISRUPTS); 14-3-3 epsilon(DISRUPTS) 21558810 3 0 3 +Il17rb IL17RB Membrane protein, integral Q9JIP3 50905 14 B|14 18.39 cM mouse Y444-p 5756439 LHKYLVVyLGGADLK SEFIR molecular association, regulation STAT5A(INDUCES) 25821217 2 0 0 +Yap1 YAP1 Oncoprotein; Transcription, coactivator/corepressor P46938 22601 9|9 A1 mouse S79-p 3253276 RLRKLPDsFFKPPEP molecular association, regulation transcription, induced TEAD1(INDUCES) 21376238 8 3 3 +Ache AChE EC 3.1.1.7; Hydrolase; Lipid Metabolism - glycerophospholipid; Membrane protein, GPI anchor P21836 11423 5 G2|5 76.32 cM mouse S234-p 54266100 SVTLFGEsAGAASVG COesterase protein conformation 26879641 1 0 0 single mutant (Y337A) mAChE gives more conformational flexibility to approach the drug molecule towards the phosphorylated conjugate without facing several steric constraints at the active-site of the enzyme. +Sh2b1 SH2-B-beta Adaptor/scaffold Q62985 89817 1q36 rat S161-p 21336502 SLRSVGRsVRGSVRG intracellular localization cell motility, induced 23444381 2 0 2 disrupt localization at the plasma membrane.; macrophage migration +Elavl4 ELAVL4 RNA-binding Q61701 15572 4 C7|4 51.42 cM mouse T165-p 40248601 SQYGRIItSRILVDQ RRM_1 intracellular localization translation, induced 25692578 1 0 0 ELAVL4 transport to dendrites +CD274 PD-L1 Membrane protein, integral Q9NZQ7 29126 9p24.1 human K263-ac 1875250200 TFIFRLRkGRMMDVK intracellular localization transcription, inhibited KPNA1(DISRUPTS); HIP1R(DISRUPTS) 32839551 1 1 0 nuclear localization that governs immune-response gene expression +HSPB1 HSP27 Chaperone; Heat shock protein; Motility/polarity/chemotaxis; SUMO LIGASE; SUMO ligase Q00649 chicken S77-p 448402 SPYGRALsELSSGIS protein conformation 12429504 40 25 30 Mutations mimicking phosphorylation of sites single (S15D) and in combination form high and low molecular oligomers and affect chaperone activity in vitro. +RAN RAN Cell cycle regulation; G protein; G protein, monomeric; G protein, monomeric, Ran; Motility/polarity/chemotaxis; Nuclear export; Nuclear receptor co-regulator P62826 5901 12q24.33 human K134-ac 36958832 KDRKVKAkSIVFHRK Ras molecular association, regulation cell cycle regulation RCC1(INDUCES); RANGRF(DISRUPTS) 29040603 1 2 0 regulates chromosome segregation +Prkd1 PRKD1 Autophagy; EC 2.7.11.13; KINASE; Kinase, protein; Motility/polarity/chemotaxis; Protein kinase, CAMK; Protein kinase, Ser/Thr (non-receptor) Q62101 18760 12|12 B3 mouse S744-p 448589 ARIIGEKsFRRSVVG Pkinase activity, induced; enzymatic activity, induced 10473617; 10867018; 12407104; 15084589; 15590638; 15623513; 34478715; 9765302 58 14 20 +PER1 PER1 Transcription factor O15534 5187 17p13.1 human S714-p 465536 ALANKAEsVVSVTSQ protein stabilization; intracellular localization 24857656 2 0 0 contribute to accelerate clock; accelerated degradation of the phosphorylation de?cient PER1 S214G mutant, more rapid nuclear import +ATP7B ATP7B EC 3.6.3.54; Hydrolase; Membrane protein, integral; Membrane protein, multi-pass; Transporter; Transporter, ion channel; Vesicle P35670 540 13q14.3 human S1453-p 11267005 DDDGDKWsLLLNGRD protein stabilization; intracellular localization 21189263 1 5 2 protein trafficking +Slc1a2 GLT1 Membrane protein, integral; Membrane protein, multi-pass; Transporter; Transporter, SLC family P31596 29482 3q32 rat S486-p 3053600 SVNVVGDsFGAGIVY SDF intracellular localization 12324450 1 0 0 +POLB POLB DNA repair, damage; DNA replication; EC 2.7.7.7; Lyase; Transferase P06746 5423 8p11.21 human K81-ub 12486800 DEFLATGkLRKLEKI protein degradation DNA repair, inhibited 19713937 1 3 0 +Adora3 ADORA3 GPCR, family 1; Membrane protein, integral; Membrane protein, multi-pass; Receptor, GPCR P28647 25370 2q34 rat T318-p 450329 LDSNLEQtTE_____ receptor desensitization, altered 10692494 1 0 0 +Srebf1 SREBP-1 iso1 DNA-binding; Membrane protein, integral; Membrane protein, multi-pass; Transcription factor P56720-1 78968 10q22 rat K98-sm 2715401 FSPGPGIkEEPVPLT sumoylation; protein degradation; ubiquitination transcription, inhibited 24379443 3 1 0 +TNNI3 TNNI3 Actin-binding; Motility/polarity/chemotaxis; Motor P19429 7137 19q13.42 human T129-p 6796400 ITEIADLtQKIFDLR Troponin molecular association, regulation; protein conformation C16orf82(INDUCES); TNC(INDUCES) 18986304 1 0 0 +TFEB TFEB DNA-binding; Transcription factor P19484 7942 6p21.1 human S467-p 4785142 KASSRRSsFSMEEGD DUF3371 intracellular localization apoptosis, inhibited 29689560 4 20 2 protects dopaminergic neurons under MPTP-induced oxidative stress ; nuclear translocation +GLI3 GLI3 C2H2-type zinc finger protein; Transcription factor P10071 2737 7p14.1 human S980-p 25780315 VHAPRRCsDGGAHGY protein processing transcription, inhibited 10693759 1 2 1 +Hand1 HAND1 Cell development/differentiation; DNA-binding; Nucleolus; Transcription factor Q64279 15110 11 B1.3|11 35.27 cM mouse T107-p 12518701 PKKERRRtESINSAF HLH intracellular localization; protein conformation cell differentiation, altered 17891141 1 0 0 release from nucleolus, dimerization +Adam17 TACE EC 3.4.24.86; Membrane protein, integral; Motility/polarity/chemotaxis; Protease Q9Z1K9 57027 6q16 rat S811-p 27457932 TRSEKAAsFKLQRQS exocytosis, induced 25232008 2 3 0 +MAP4K4 HGK EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, STE; Protein kinase, Ser/Thr (non-receptor) O95819 9448 2q11.2 human T187-p 480118 RTVGRRNtFIGTPYW Pkinase enzymatic activity, induced carcinogenesis, induced; cell growth, induced; cell adhesion, inhibited 12612079 1 10 102 increased networks of invading cells +RAF1 RAF1 EC 2.7.11.1; KINASE; Kinase, protein; Oncoprotein; Protein kinase, Ser/Thr (non-receptor); Protein kinase, TKL P04049 5894 3p25.2 human S301-p 455219 SSSPNNLsPTGWSQP molecular association, regulation; intracellular localization; enzymatic activity, inhibited; enzymatic activity, induced HRas(DISRUPTS) 15642359; 15664191; 16407412 5 25 65 phosphorylation of S289, S296, and S301 sustains and increases kinase activity +PLCG1 PLCG1 Carbohydrate Metabolism - inositol phosphate; EC 3.1.4.11; Motility/polarity/chemotaxis; Phospholipase P19174 5335 20q12 human S1248-p 448665 HGRAREGsFESRYQQ enzymatic activity, inhibited 21840932 4 33 235 +CAT Catalase Amino Acid Metabolism - tryptophan; Apoptosis; EC 1.11.1.6; Endoplasmic reticulum; Energy Metabolism - methane; Hydrolase; Mitochondrial; Oxidoreductase P04040 847 11p13 human Y231-p 450444 NANGEAVyCKFHYKT Catalase enzymatic activity, induced 12777400 2 9 310 +Pparg PPAR-gamma DNA-binding; Nuclear receptor; Transcription factor P37238 19016 6 E3|6 53.41 cM mouse K268-ac 25780500 ARAILTGkTTDKSPF protein degradation; acetylation; molecular association, regulation N-CoR1(INDUCES) 22863012; 36394167 4 1 0 Impairs adipose plasticity During metabolic adaptions, mediates the diurnal cycle of adipose metabolism by destabilizing BMAL, rhythmicity in glucose tolerance and insulin sensitivity; deacetylation mediates TZD-induced browning of white adipocytes enhancing expression of BAT genes +PPIA PPIA Cyclophilin; EC 5.2.1.8; Isomerase; RNA-binding P62937 5478 7p13 human K125-ac 466190 KTEWLDGkHVVFGKV Pro_isomerase exocytosis, induced; cell adhesion, induced; signaling pathway regulation 24293519 2 9 62 secretion in VSMC, regulates VSMC activation pathway +LBR LBR DNA-binding; Membrane protein, integral; Membrane protein, multi-pass G1N806 turkey S78-p 18911472 SPSRRSRsRSRSRSP molecular association, regulation; protein conformation H3(INDUCES) 22056509 2 6 4 +Nfkbia IkB-alpha DNA-binding; Inhibitor Q9Z1E3 18035 12|12 C1 mouse S32-p 448203 LVDDRHDsGLDSMKD protein degradation carcinogenesis, inhibited; apoptosis, induced; cell growth, inhibited; transcription, induced 10497169; 12070292; 22633953; 34145038; 35637461; 36309088 161 3 17 +TAB2 TAB2 Adaptor/scaffold Q9NYJ8 23118 6q25.1 human S423-p 456007 SAASRNMsGQVSMGP molecular association, regulation; intracellular localization ER-alpha(INDUCES) 12150997; 27992601 2 0 0 +MAP3K11 MLK3 EC 2.7.11.25; KINASE; Kinase, protein; Protein kinase, Ser/Thr (non-receptor); Protein kinase, TKL Q16584 4296 11q13.1 human S674-p 448790 PGRERGEsPTTPPTP activity, inhibited carcinogenesis, induced; apoptosis, inhibited 12458207; 26152725 4 0 0 +TP53BP1 53BP1 DNA repair, damage; Transcription, coactivator/corepressor Q12888 7158 15q15.3 human T302-p 460977 PEPEVLStQEDLFDQ molecular association, regulation DNA repair, induced RIF1(INDUCES) 31390554 2 8 12 regulates Rif1 localization +C5AR1 C5aR GPCR, family 1; Membrane protein, integral; Membrane protein, multi-pass; Receptor, GPCR P21730 728 19q13.32 human S314-p 450055 FQGRLRKsLPSLLRN molecular association, regulation ARRB1(INDUCES); ARRB2(INDUCES) 12464600 2 1 0 +Bcl2l11 BIM Apoptosis O54918 12125 2|2 F1 mouse S55-p 454235 GDRCPHGsPQGPLAP protein degradation; molecular association, regulation apoptosis, altered; apoptosis, inhibited BAX(DISRUPTS) 15486085; 17105963; 18498746 7 1 0 +Adcy6 ADCY6 Adenylyl cyclase; EC 4.6.1.1; Lyase; Membrane protein, integral; Membrane protein, multi-pass; Nucleotide Metabolism - purine; Transporter; Transporter, aquaporin family AAA40678 25289 7q36 rat T931-p 455530 HAQQVEStARLDFLW enzymatic activity, inhibited 11877398 1 0 0 +Gria1 GluR1 Channel, calcium; Channel, ligand-gated; Membrane protein, integral; Membrane protein, multi-pass P19490 50592 10q22 rat K840-ac 206219722 RSESKRMkGFCLIPQ protein stabilization; ubiquitination; receptor internalization, inhibited neural plasticity 28793258 1 0 0 inhibits ubiquitination; impaired learning and memory +cdc25c-b CDC25C EC 3.1.3.48; Motility/polarity/chemotaxis; PHOSPHATASE; Protein phosphatase, dual-specificity P30309 398119 frog T48-p 448419 FSPEQPLtPVTDLAV molecular association, regulation cell cycle regulation CKS1(INDUCES); PIN1(INDUCES) 11013245 7 10 15 Pin1 and CKS1 compete for binding to phosphorylated T48 Cdc25C. +POU5F1 Oct4 DNA-binding; Transcription factor Q01860 5460 6p21.33 human S12-p 18496900 LASDFAFsPPPGGGG protein stabilization; molecular association, regulation transcription, altered PIN1(INDUCES) 21296877 2 0 0 +CTNNAL1 CTNNAL1 Adaptor/scaffold Q9UBT7 8727 9q31.3 human Y534-p 3701811 EGRRGEKyGYLSLPK intracellular localization 17952117 1 3 4 mutantsand wild-type were localized throughout the cytoplasm, and partially associated with the plasma membrane +Esr2 ER-beta DNA-binding; Nuclear receptor O08537 13983 12 C3|12 33.52 cM mouse Y488-p 450057 CKNVVPVyDLLLEML transcription, induced 9500442 3 1 0 +Slc24a2 SLC24A2 Membrane protein, integral; Membrane protein, multi-pass; Transporter; Transporter, SLC family O54701 84550 5q32 rat S504-p 471068 PDVRKPAsKKFFPIT activity, induced 17038313 1 0 0 Mutation to alanine of T476 and either T166 or S504 (or possibly both) eliminates PDBu-induced enhancement (PIE) on the Na(+)/Ca(2+)+K(+) exchanger. +Myod1 MyoD DNA-binding; RNA splicing; Transcription factor P10085 17927 7 B3|7 30.03 cM mouse S5-p 470072 ___MELLsPPLRDID protein degradation; molecular association, regulation; intracellular localization cell cycle regulation; transcription, altered HDAC1(INDUCES); PCAF(DISRUPTS) DNA(DISRUPTS) 14749395; 17014844 3 0 0 +ALK ALK EC 2.7.10.1; KINASE; Kinase, protein; Membrane protein, integral; Oncoprotein; Protein kinase, TK; Protein kinase, tyrosine (receptor) Q9UM73 238 2p23.2-p23.1 human Y1604-p 447828 TAPGAGHyEDTILKS molecular association, regulation; intracellular localization; phosphorylation; enzymatic activity, induced cell cycle regulation; carcinogenesis, induced; cell growth, induced PLCG1(INDUCES) 34270745; 35411036; 9819383 11 5 53 induces phosphorylation of downstream targets, ERK, AKT, STAT3; The complex formation leads to the tyrosine phosphorylation and activation of PLC-gamma. +Foxo4 FOXO4 DNA-binding; Oncoprotein; Transcription factor Q9WVH3 54601 X D|X 43.89 cM mouse K186-ac 459042 MLNPDGGkGGKAPRR Forkhead transcription, inhibited 16012755 2 0 0 +XRCC6 Ku70 DNA repair, damage; DNA-binding; EC 3.6.4.-; EC 4.2.99.-; Helicase; Nuclear receptor co-regulator; RNA-binding P12956 2547 22q13.2 human S77-p 1875071706 VYISKIIsSDRDLLA Ku_N molecular association, regulation; acetylation; intracellular localization DNA repair, inhibited; transcription, inhibited 14-3-3 beta(INDUCES); SIRT1(DISRUPTS) DNA(DISRUPTS) 34635772 1 1 0 +Irf8 IRF8 DNA-binding; Transcription factor P23611 15900 8 E1|8 70.05 cM mouse K310-sm 27490406 VCKGRPNkLERDEVV IRF-3 molecular association, regulation cell differentiation, induced; transcription, inhibited DNA(DISRUPTS) 22942423; 27137933; 32049023 3 0 0 osteoclastogenesis +RASGRF1 RASGRF1 GEF; GEF, Ras Q13972 5923 15q25.1 human S927-p 448487 KEKYRRMsLASAGFP activity, induced 10601308 3 0 0 necessary but not sufficient for RasGRF1 activation +SQSTM1 SQSTM1 Autophagy; Nuclear receptor co-regulator; Ubiquitin conjugating system Q13501 8878 5q35.3 human S407-p 40253303 QMLSMGFsDEGGWLT UBA_5 molecular association, regulation autophagy, induced ubiquitin(INDUCES) 27846364; 29147513; 33084718 3 2 0 binding K63 diubiquitin ; required for inclusion formation by ubiquitinated proteins +KCNA2 Kv1.2 Channel, potassium; Membrane protein, integral; Membrane protein, multi-pass P16389 3737 1p13.3 human Y132-p 452037 MFREDEGyIKEEERP activity, inhibited 15215309; 23769686 3 0 0 this site is required for channel suppression and channel endocytosis; gintonin inhibits Kv1.2 channel activity +VIM Vimentin Cytoskeletal; Motility/polarity/chemotaxis P08670 7431 10p13 human K445-sm 55461976 SKRTLLIkTVETRDG cell motility, induced; cytoskeletal reorganization; cell growth, altered 32047143 1 3 0 increases its solubility +Pdgfrb PDGFRB EC 2.7.10.1; KINASE; Kinase, protein; Membrane protein, integral; Oncoprotein; Protein kinase, TK; Protein kinase, tyrosine (receptor) Q05030 rat Y1020-p 447523 PNETDNDyIIPLPDP enzymatic activity, induced cell cycle regulation; cell growth, induced; signaling pathway regulation 23776396 21 0 0 downstream signaling pathway phosphorylation of STAT3, ERK1/2, Akt, and PLCG1 was determined in PDGF-stimulated VSMCs +Ppp1r9b Spinophilin Adaptor/scaffold; Protein phosphatase, regulatory subunit Q6R891 217124 11|11 D mouse S94-p 448728 SDRGVRLsLPRASSL cell differentiation, induced; cytoskeletal reorganization 33389417 7 8 1 +HEXIM1 HEXIM1 Motility/polarity/chemotaxis; Transcription factor O94992 10614 17q21.31 human K296-ub 9805703 KEYLELEkCLSRMED HEXIM transcription, inhibited 19617712 1 1 0 +ZBTB16 PLZF C2H2-type zinc finger protein; DNA-binding; Oncoprotein; Transcription, coactivator/corepressor Q05516 7704 11q23.2 human K387-sm 2303903 IQRELFSkLGELAVG cell growth, inhibited; transcription, inhibited 17498654 1 0 0 +LTF LTF EC 3.4.21.-; Protease; Secreted; Secreted, signal peptide P02788 4057 3p21.31 human K423-sm 41400401 GYVYTAGkCGLVPVL Transferrin protein stabilization transcription, inhibited 26090800 1 0 0 +TENT2 PAPD4 EC 2.7.7.19; RNA processing; Transferase Q6PIY7 167153 5q14.1 human S62-p 14160718 QLTYGNVsPIQTSAS molecular association, regulation; enzymatic activity, altered; enzymatic activity, induced RNA stability, altered RNA(INDUCES) 31057087; 34288801 2 6 0 +CLDN1 Claudin-1 Cytoskeletal; Membrane protein, integral; Membrane protein, multi-pass Q5ZMG2 424910 chicken T206-p 460032 YPKNAPStGKDYV__ activity, induced 16500087 1 4 1 critical for proper heart asymmetric positioning in the chicken embryo +Osbpl3 OSBPL3 iso3 Endoplasmic reticulum D3Z194 71720 6|6 B2.3 mouse S264-p 6209027 IQGGAFEsPKKEKRP apoptosis, inhibited 31509750 1 23 4 inhibits insulin secretion +MAP3K11 MLK3 EC 2.7.11.25; KINASE; Kinase, protein; Protein kinase, Ser/Thr (non-receptor); Protein kinase, TKL Q16584 4296 11q13.1 human K264-ub 36324902 DMEHKTLkITDFGLA PK_Tyr_Ser-Thr protein degradation 25204656 1 1 0 +Sod2 SOD2 EC 1.15.1.1; Mitochondrial; Oxidoreductase P09671 20656 17 A1|17 8.75 cM mouse K202-ac 27585061 NVRPDYLkAIWNVIN Sod_Fe_C protein conformation 28433661 0 4 0 mediates pentameric SOD2 deaggregation +Cftr CFTR Channel, chloride; EC 3.6.3.49; Hydrolase; Membrane protein, integral; Membrane protein, multi-pass; Transporter; Transporter, ABC family P26361 12638 6 A2|6 8.1 cM mouse S422-p 3333404 SNGDRKHsSDENNVS protein conformation 19927121 4 3 0 in vitro +PDGFRA PDGFRA EC 2.7.10.1; KINASE; Kinase, protein; Membrane protein, integral; Oncoprotein; Protein kinase, TK; Protein kinase, tyrosine (receptor) P16234 5156 4q12 human Y754-p 448439 ERKEVSKySDIQRSL PK_Tyr_Ser-Thr molecular association, regulation SHP-2(INDUCES) 11896619; 7523122 5 5 32 a 134kDa and a 70kDa protein +SH3KBP1 SH3KBP1 Adaptor/scaffold; Apoptosis; Motility/polarity/chemotaxis Q96B97 30011 Xp22.12 human K598-sm 25336500 FGTEGKPkMEPAASS molecular association, regulation; intracellular localization NPHS1(DISRUPTS) 22203040 1 0 0 +Thra TR-alpha iso2 DNA-binding; Nuclear receptor; Transcription factor P63059-2 81812 rat K389-sm 27490405 ASRFLHMkVECPTEL Hormone_recep transcription, altered 22930759 3 0 0 +Slc2a2 GLUT2 Membrane protein, integral; Membrane protein, multi-pass; Transporter; Transporter, SLC family P12336 25351 2q24 rat S503-p 451346 EFRKKSGsAPPRKAT activity, inhibited 8626492 1 0 0 Phosphorylation reduces the initial rate of 3-O-methyl glucose uptake. +WDR62 WDR62 Adaptor/scaffold O43379 284403 19q13.12 human S33-p 453570 PARRGQSsPPPAPPI cell cycle regulation 25501809; 26713495 2 26 124 WDR62 regulation of the mitotic spindle; microtubule association +Map2k1 MEK1 EC 2.7.12.2; KINASE; Kinase, protein; Protein kinase, STE; Protein kinase, dual-specificity (non-receptor) Q01986 170851 8q24 rat S218-p 448514 VSGQLIDsMANSFVG Pkinase enzymatic activity, induced 8034665; 8157000 124 13 83 +GFI1 GFI1 C2H2-type zinc finger protein; Cell cycle regulation; Cell development/differentiation; Transcription factor Q99684 2672 1p22.1 human S94-p 41452096 EDFWRPPsPSASPAS protein degradation; molecular association, regulation; ubiquitination carcinogenesis, altered; signaling pathway regulation FBXW7(INDUCES) 31289136 1 2 0 +HSPA1A HSP70 Chaperone; Heat shock protein; Motility/polarity/chemotaxis P0DMV8 3303 6p21.33 human T636-p 18010647 GGSGSGPtIEEVD__ protein stabilization; molecular association, regulation carcinogenesis, induced; cell growth, induced HOPX(INDUCES); CHIP(DISRUPTS) 22824801; 35148989 2 8 0 cell proliferation increased +YAP1 YAP1 Oncoprotein; Transcription, coactivator/corepressor P46937 10413 11q22.1 human S400-p 9764918 SRDESTDsGLSMSSY protein degradation; ubiquitination carcinogenesis, inhibited; cell motility, inhibited 36828627 2 8 0 +Cdh5 CDH5 Cell adhesion; Membrane protein, integral; Motility/polarity/chemotaxis P55284 12562 8 D3|8 53.04 cM mouse S665-p 2562900 YDVSVLNsVRGGSTK ubiquitination; intracellular localization 26668327 3 0 0 +RELA NFkB-p65 DNA-binding; Nuclear receptor co-regulator; Transcription factor Q04206 5970 11q13.1 human K310-m1 19006700 KRTYETFkSIMKKSP molecular association, regulation carcinogenesis, induced; cell growth, induced; transcription, induced; signaling pathway regulation GLP-1(INDUCES) 21515635; 28122346 2 1 0 +GATA1 GATA1 DNA-binding; Transcription factor P15976 2623 Xp11.23 human K316-ac 466359 ASGKGKKkRGSSLGG molecular association, regulation transcription, altered DNA(INDUCES) 16888089 2 0 0 +MCU MCU Membrane protein, integral; Membrane protein, multi-pass; Mitochondrial Q8NE86 90550 10q22.1 human S57-p 27259016 TVHQRIAsWQNLGAV activity, induced; intracellular localization cell cycle regulation 30858581 2 0 0 Regulates mitochondrial Ca2+ uptake and mitotic progression +Ppfia1 liprin alpha 1 Cell adhesion; Motility/polarity/chemotaxis B2RXW8 233977 7|7 F5 mouse T700-p 31873705 PPGSGRStPRRVPHS molecular association, regulation; intracellular localization PSD-95(DISRUPTS) 28760951 1 1 0 regulates synaptic plasticity +Scnn1g ENaC-gamma Channel, sodium; Membrane protein, integral; Membrane protein, multi-pass; Transporter, ion channel P37091 24768 1q36 rat K12-ub 486253 EKIKAKIkKNLPVRG receptor recycling, inhibited; protein degradation; intracellular localization 9351815 1 0 0 +PML PML Nucleolus; Oncoprotein; SUMO LIGASE; SUMO conjugating system; SUMO ligase; Transcription factor; Tumor suppressor; Ubiquitin conjugating system P29590 5371 15q24.1 human K65-sm 2793914 QQCQAEAkCPKLLPC protein degradation; molecular association, regulation; ubiquitination; intracellular localization; phosphorylation carcinogenesis, induced; cell differentiation, induced; transcription, induced PIAS1(INDUCES); CK2A1(INDUCES); SUMO1(INDUCES); RNF4(INDUCES) 10779416; 17989716; 18408733; 19106612; 19380586; 22406621; 23542129; 27099310; 9756909 14 2 0 +ERCC6 ERCC6 DNA repair, damage; EC 3.6.1.-; EC 3.6.4.-; Helicase; Transcription regulation Q03468 2074 10q11.23 human S1276-p 31874464 DAIMDGAsPDYVLVE molecular association, regulation; intracellular localization DNA repair, altered BRCA1(INDUCES) 31501894 1 2 0 induces cell survival, recruits BRCA1-C complex to DSBs +Stxbp5 STXBP5 Vesicle Q8K400 78808 10|10 A1 mouse K298-sm 31957310 EPCKPILkVELKTTR LLGL neural plasticity 24614299 2 0 0 +RUNX2 AML3 DNA-binding; Transcription factor Q13950 860 6p21.1 human S312-p 10892802 SYLSQMTsPSIHSTT molecular association, regulation transcription, induced osterix(INDUCES) 19801668; 25122769; 27687725 11 1 0 +LIG1 LIG1 DNA repair, damage; EC 6.5.1.1; Ligase P18858 3978 19q13.33 human K376-ub 21178024 VRAEAAEkGDVGLVA DNA_ligase_A_N protein degradation 27573245 1 3 0 +FHOD1 FHOD1 Actin-binding Q9Y613 29109 16q22.1 human Y99-p 31010701 REMLEGFyEEISKGR Formin_GBD_N activity, induced; intracellular localization cell motility, induced; cell adhesion, induced; cytoskeletal reorganization 24331927 1 0 0 induce actin polymerization +THBS1 THBS1 Inhibitor; Motility/polarity/chemotaxis P07996 7057 15q14 human K173-ub 52490406 QLYIDCEkMENAELD protein degradation 26676607 0 1 0 +ELK4 ELK4 DNA-binding; Transcription, coactivator/corepressor P28324 2005 1q32.1 human S387-p 4317601 LSPVAPLsPARLQGA cell growth, induced; transcription, induced 26028036; 9130707 3 0 0 +Nfe2l2 NRF2 DNA-binding; Transcription factor Q60795 18024 2 C3|2 44.75 cM mouse S335-p 18258505 MEFNDSDsGISLNTS protein degradation; molecular association, regulation; activity, inhibited carcinogenesis, induced BTRC(INDUCES) 21245377; 22751928; 22964642; 24892215 4 1 0 +Fcgr2 FCGR2B Cell surface; Membrane protein, integral; Oncoprotein P08101 14130 1 H3|1 78.02 cM mouse Y309-p 448507 EAENTITySLLKHPE activity, induced; phosphorylation 11035084 4 2 1 regulates Ca(2+) influx, ERK activation, SHIP phosphorylation +FMNL2 FMNL2 Cytoskeletal Q96PY5 114793 2q23.3 human S1072-p 1868070803 ARTAKRGsRFFCEPV receptor internalization, induced 31751425 1 0 0 integrin beta 1 internalization +TARDBP TDP-43 RNA-binding Q13148 23435 1p36.22 human T153-p 63083902 GFGFVRFtEYETQVK RRM_1 molecular association, regulation; intracellular localization RNA(DISRUPTS) 28167528 1 0 0 nuclear recruitment, decrease RNA binding affinity (fluorescence-based RNA binding assay, regulation of splicing +Abi1 Abi-1 Adaptor/scaffold; Motility/polarity/chemotaxis Q8CBW3 11308 2 A3|2 15.18 cM mouse Y213-p 449523 PPTVPNDyMTSPARL protein stabilization; molecular association, regulation cell differentiation, inhibited; cytoskeletal reorganization; cell adhesion, altered Abl(INDUCES) 21320496; 32673396 5 42 680 enhances cell adhesion in Bcr-Abl expressing cells; Regulate epiblast differentiation and polarizations; induces the catalytic activity of c-Abl in vitro +Pde3b PDE3B EC 3.1.4.17; Membrane protein, integral; Membrane protein, multi-pass; Nucleotide Metabolism - purine; Phosphodiesterase Q63085 29516 1q34 rat S302-p 449873 GKMFRRPsLPCISRE molecular association, regulation; enzymatic activity, induced 14-3-3 beta(INDUCES) 12453887; 8626720 7 18 27 +IRAK4 IRAK4 EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, Ser/Thr (non-receptor); Protein kinase, TKL Q9NWZ3 51135 12q12 human T345-p 2045325 KFAQTVMtSRIVGTT PK_Tyr_Ser-Thr molecular association, regulation; protein conformation; enzymatic activity, induced IRAK4(DISRUPTS) 17141195; 17161373; 17312103; 25201411 8 4 0 IRAK4 dimerization is inhibited by phosphorylation of this site +Scn2a SCN2A Channel, sodium; Membrane protein, integral; Membrane protein, multi-pass P04775 24766 3q21 rat Y1497-p 1046202 MTEEQKKyYNAMKKL activity, inhibited 17959797 1 0 0 +Gna15 G-alpha 15 G protein; G protein, heterotrimeric; G protein, heterotrimeric alpha G(q) P30678 14676 10 C1|10 39.72 cM mouse S334-p 11380904 QDGGRKGsRARRFFA G-alpha activity, induced 12647293 1 0 0 GNA15 receptor mediated PLC-B activation +Ephb2 EphB2 EC 2.7.10.1; KINASE; Kinase, protein; Membrane protein, integral; Protein kinase, TK; Protein kinase, tyrosine (receptor); Tumor suppressor P54763 13844 4 D3|4 69.0 cM mouse Y602-p 448327 IYIDPFTyEDPNEAV EphA2_TM molecular association, regulation; enzymatic activity, induced cytoskeletal reorganization; cell adhesion, altered NMDAR1(INDUCES); RASA1(INDUCES); Src iso1(INDUCES) 10644995; 10848605; 11136979; 16977320 7 20 120 in vitro +Abcc2 ABCC2 Membrane protein, integral; Membrane protein, multi-pass; Transporter; Transporter, ABC family Q63120 25303 1q54 rat K949-sm 6335600 VEGQKLIkKEFVETG protein stabilization 19074644 1 0 0 siRNA of UBC9 reduces ABCC2 protein expression by 30% +Lipe HSL EC 3.1.1.79; Lipase P15304 25330 1q21 rat S900-p 450193 GNSEPSDsPEMSQSM enzymatic activity, induced 11581251 1 0 0 +CRTC3 TORC3 Transcription, coactivator/corepressor Q6UUV7 64784 15q26.1 human S391-p 3203130 RRRQPPVsPLTLSPG intracellular localization carcinogenesis, induced; transcription, induced 34010639 1 21 33 +Cacng2 Stargazin Channel, calcium; Membrane protein, integral; Membrane protein, multi-pass Q71RJ2 84347 7q34 rat S243-p 455318 RSRSSSRsTEPSHSR molecular association, regulation neural plasticity PSD-95(INDUCES) 25843401 3 0 0 +PSME3 PSME3 Nuclear receptor co-regulator; Protease; Proteasome complex P61289 10197 17q21.31 human K6-sm 25344504 __MASLLkVDQEVKL protein stabilization; intracellular localization; enzymatic activity, induced 21445096 1 0 0 +H3-3A H3F3A DNA-binding P84243 3020 1q42.12 human K9-m1 18545324 RTKQTARkSTGGKAP Histone phosphorylation 16185088 1 2 14 detecting S10 phosphorylation with phospho-antibody was disrupted in dual modified peptides with K9ac and K9 monomethyl as was S28 with K27ac +Hnrnpf hnRNP F RNA splicing; RNA-binding; Spliceosome Q794E4 64200 4q42 rat K87-ac 11320528 HRYIEVFkSHRTEMD protein stabilization RNA splicing, induced 25959059 1 5 0 +Stat5b STAT5B DNA-binding; Oncoprotein; Transcription factor P52632 25126 10q31 rat S730-p 448751 TYMDQAPsPVVCPQA transcription, induced 24489959 14 0 0 +HADHA HADHA ACETYLTRANSFERASE; Acetyltransferase; Amino Acid Metabolism - lysine degradation; Amino Acid Metabolism - tryptophan; Amino Acid Metabolism - valine, leucine and isoleucine degradation; Carbohydrate Metabolism - butanoate; Carbohydrate Metabolism - propanoate; EC 1.1.1.211; EC 4.2.1.17; Lipid Metabolism - fatty acid; Lipid Metabolism - fatty acid elongation in mitochondria; Lipid Metabolism - unsaturated fatty acid biosynthesis; Lyase; Mitochondrial; Other Amino Acids Metabolism - beta-alanine; Oxidoreductase; Secondary Metabolites Metabolism - limonene and pinene degradation P40939 3030 2p23.3 human K350-ac 466489 YHGQVLCkKNKFGAP protein stabilization 27457618 2 7 33 3 sites can be acetylated or ubiquitylated, acetylation blocks ubiquitylation +PAX8 PAX8 Transcription factor Q06710 7849 2q14.1 human S209-p 1877752105 DQDSCRLsIDSQSSS protein stabilization 31391550 1 0 0 +STMN3 STMN3 Cytoskeletal Q9NZ72 50861 20q13.33 human S73-p 454283 PESPMLSsPPKKKDT Stathmin intracellular localization 22577147 2 6 2 +CBX8 CBX8 Transcription, coactivator/corepressor Q9HC52 57332 17q25.3 human S196-p 1874101936 PSSPGDSsKKRGPKP protein degradation cell differentiation, induced; transcription, induced 34253692 1 1 0 +ACVR1 ALK2 EC 2.7.11.30; KINASE; Kinase, protein; Membrane protein, integral; Protein kinase, Ser/Thr (receptor); Protein kinase, TKL Q04771 90 2q24.1 human T203-p 36440209 LPFLVQRtVARQITL TGF_beta_GS enzymatic activity, inhibited 25354296 1 0 0 +F11r JAM-A Cell adhesion; Membrane protein, integral O88792 16456 1 H3|1 79.43 cM mouse Y281-p 458767 APGKKVIySQPSTRS enzymatic activity, inhibited carcinogenesis, altered; cell motility, inhibited 36185363 3 27 902 inhibits Src activity +SLC6A1 SLC6A1 Membrane protein, integral; Membrane protein, multi-pass; Transporter; Transporter, SLC family P30531 6529 3p25.3 human Y107-p 11382801 LECSLGQyTSIGGLG SNF activity, induced; receptor internalization, altered; intracellular localization 11555659 1 0 0 +Nos1 nNOS Amino Acid Metabolism - arginine and proline; EC 1.14.13.39; Oxidoreductase P29476 24598 12q16 rat S847-p 447886 SYKVRFNsVSSYSDS Flavodoxin_1 enzymatic activity, inhibited 10874031; 16984226 11 3 5 +CAPZB CAPZB iso1 Actin-binding; Motility/polarity/chemotaxis P47756-1 832 1p36.13 human T267-p 34732611 RELSQVLtQRQIYIQ protein conformation cytoskeletal reorganization; signaling pathway regulation 30808692 1 0 12 stiffness increased CapZ FRAP dynamics; phosphorylation of this site is modified by binding to phosphatidylinositol 4,5-bisphosphate (PIP2) +KRT19 K19 Cytoskeletal P08727 3880 17q21.2 human S35-p 449970 GVAFRAPsIHGGSGG molecular association, regulation; intracellular localization carcinogenesis, induced; cytoskeletal reorganization HER2(INDUCES) 10212274; 25342465 3 15 115 membrane localization; Phosphorylation fo K19 regulates its 'Subcellular shape- filamentous to granulated morphology'. +TRIM28 TIF1B EC 6.3.2.-; KINASE; Kinase, protein; Ligase; Nuclear receptor co-regulator; Protein kinase, atypical; SUMO LIGASE; SUMO ligase; Transcription, coactivator/corepressor; UBIQUITIN LIGASE; Ubiquitin conjugating system; Ubiquitin ligase Q13263 10155 19q13.43 human K575-sm 3142605 ATEGPETkPVLMALA transcription, inhibited 31391303 2 4 0 loss of TF1B sumoylation induces dsRNA-activated IFN-mediated defenses that rely on RIG-I, MAVS, TBK1, and JAK1 transcription, SUMOylated TIF1B Is required to support efficient virus replication +Cttn Cortactin Actin-binding; Cytoskeletal; Motility/polarity/chemotaxis NP_001385572 60465 1q41-q42 rat T219-p 15418706 GFEYQGKtEKHESQK HS1_rep molecular association, regulation cytoskeletal reorganization; cell motility, inhibited ACTB(DISRUPTS) 30570111 1 1 2 decrease actin bundling, altered higher order structure of dynamin1-cort complex, deformed lamelipodia and short filopodia +Cryaa CRYA1 Chaperone; Heat shock protein P24623 24273 20p12 rat S45-p 452105 PFLSSTIsPYYRQSL Crystallin apoptosis, inhibited 21615407 1 2 0 induces cytoprotection against C2-ceramide and staurosporine induced cell death +Ctnnd2 CTNND2 Actin-binding; Motility/polarity/chemotaxis O35927 18163 15|15 B2 mouse S357-p 4697626 IGTYATLsPTKRLVH molecular association, regulation; intracellular localization cytoskeletal reorganization PSD-95(DISRUPTS); GRIP1(DISRUPTS) 20573893 1 1 0 +SET SET Apoptosis; DNA replication; DNA-binding; Inhibitor; Nuclear receptor co-regulator; Oncoprotein; Protein phosphatase, regulatory subunit Q01105 6418 9q34.11 human K172-ub 15397496 SSKSTEIkWKSGKDL NAP protein degradation 35843886 1 6 1 +Anxa1 ANXA1 Calcium-binding; Lipid-binding P10107 16952 19 B|19 13.83 cM mouse Y21-p 447974 LENQEQEyVQAVKSY sumoylation; ubiquitination 23727357 5 16 171 inhibits ubiquitylation; induces sumoylation at K257 +OPRM1 MOR-1 GPCR, family 1; Membrane protein, integral; Membrane protein, multi-pass; Receptor, GPCR P35372 4988 6q25.2 human S377-p 447784 QNTRDHPsTANTVDR receptor desensitization, induced; receptor internalization, altered signaling pathway regulation 18463167; 21292762; 22375000 24 5 0 inhibitor of PKCE activation; inactivation of MOP receptor +DDX17 DDX17 iso3 EC 3.6.4.13; Helicase; Nuclear receptor co-regulator; Nucleolus; RNA processing; RNA-binding; Spliceosome; Transcription, coactivator/corepressor Q92841-3 10521 22q13.1 human K42-ac 15211508 GERLRKKkWDLSELP protein stabilization; molecular association, regulation cell cycle regulation; apoptosis, inhibited; transcription, induced HDAC3(INDUCES); HDAC1(INDUCES) 20663877 1 1 2 +Atat1 ATAT1 iso2 ACETYLTRANSFERASE; Acetyltransferase; EC 2.3.1.108 Q8K341-2 73242 17|17 B1 mouse K56-ac 27581502 ELGKASAkAQHLPAP Acetyltransf_16 enzymatic activity, induced 23275437 1 1 0 +Itpr1 IP3R1 Channel, calcium; Channel, ligand-gated; Membrane protein, integral; Membrane protein, multi-pass P11881 16438 6 E1|6 49.74 cM mouse S1588-p 450681 RNAARRDsVLAASRD activity, induced; phosphorylation transcription, induced; signaling pathway regulation 17257671; 22495310 10 51 3 induce calcineurin activation, CRTC2 dephosphorylation and activation IP3R1 and gluconeogenesis.; Ca(2+) mobilization +Arhgap12 ARHGAP12 GAP; GAP, Rac/Rho Q8C0D4 75415 18|18 A1 mouse S238-p 451931 PNQGRPDsPVYANLQ SH3-WW_linker cell cycle regulation; cell motility, altered 18515860 0 69 761 +RNF157 RNF157 UBIQUITIN LIGASE; Ubiquitin conjugating system; Ubiquitin ligase Q96PX1 114804 17q25.1 human S661-p 4333533 AQRRRLSsSSLEDSE protein degradation; molecular association, regulation; ubiquitination CDH1(INDUCES) 28655764 1 2 2 +Pip5k1c PIP5K1C Carbohydrate Metabolism - inositol phosphate; EC 2.7.1.68; Kinase, lipid; Motility/polarity/chemotaxis O70161 18717 10|10 C1 mouse Y634-p 486321 DAPSTDIyFPTDERS molecular association, regulation; intracellular localization cell growth, induced; cell motility, induced; cell adhesion, induced; cytoskeletal reorganization PLCG1(DISRUPTS) 17635937; 28388589 3 0 0 focal adhesion assembly, cell migration, and matrix degradation +AKAP11 AKAP11 Adaptor/scaffold; Motility/polarity/chemotaxis Q9UKA4 11215 13q14.11 human T1136-p 40509053 AKEFAPAtPPSTPHN molecular association, regulation; intracellular localization GSK3B(INDUCES) 26088133 1 4 0 AKAP11-GSK3B complexes are present in membrane ruffles. PKA modulates GSK3? binding to AKAP11. +GTF2I GTF2I DNA-binding; Transcription, coactivator/corepressor P78347 2969 7q11.23 human K219-m1 58123202 GGSCGPIkVKTEPTE molecular association, regulation L3MBTL iso4(INDUCES) 23583077 0 1 0 +PTPN3 PTPN3 EC 3.1.3.48; Motility/polarity/chemotaxis; PHOSPHATASE; Protein phosphatase, tyrosine (non-receptor) P26045 5774 9q31.3 human S359-p 451191 PAMRRSLsVEHLETK molecular association, regulation 14-3-3 beta(INDUCES) 9341175 1 23 3 +Vasp VASP Cytoskeletal; Motility/polarity/chemotaxis B5DEX4 361517 1q21 rat T274-p 448381 LARRRKAtQVGEKPP cytoskeletal reorganization; cell motility, inhibited 23203966 11 3 19 +PLK4 PLK4 EC 2.7.11.21; KINASE; Kinase, protein; Nucleolus; Protein kinase, Other; Protein kinase, Ser/Thr (non-receptor) O00444 10733 4q28.1 human S305-p 12122401 SSTSISGsLFDKRRL intracellular localization cell cycle regulation 20032307 4 1 0 enhances centriole amplification +MRE11 MRE11A Cell cycle regulation; DNA repair, damage; DNA-binding; Deoxyribonuclease P49959 4361 11q21 human S558-p 3191332 AEQMANDsDDSISAA protein stabilization; molecular association, regulation PIH1D1(INDUCES) 28436950 1 5 4 +Trpv1 TRPV1 Channel, cation; Membrane protein, integral; Membrane protein, multi-pass; Receptor, misc. Q704Y3 193034 11 B4|11 45.25 cM mouse T371-p 455383 RHLSRKFtEWAYGPV receptor desensitization, altered 16954222 4 0 0 +DUT dUTPase iso2 DNA replication; EC 3.6.1.23; Hydrolase; Mitochondrial; Motility/polarity/chemotaxis; Nuclear receptor co-regulator; Nucleotide Metabolism - pyrimidine P33316-2 1854 15q21.1 human S11-p 451166 SEETPAIsPSKRARP intracellular localization; protein conformation KPNA2(DISRUPTS) 24311590 4 36 11 S11 phosphorylation excludes nuclear entry. +Trpv5 TRPV5 Channel, cation; Membrane protein, integral; Membrane protein, multi-pass; Motility/polarity/chemotaxis Q9XSM3 rabbit S654-p 470109 YVEAFKCsDKEDGQE activity, induced; intracellular localization 18305097; 19157541 3 0 0 CaR-dependent channel activation; inhibits caveolar endocytosis of TRPV5 +Gata1 GATA1 DNA-binding; Transcription factor P17679 14460 X A1.1|X 3.59 cM mouse S178-p 451236 PFFSPTGsPLSSAAY protein degradation; acetylation; molecular association, regulation; ubiquitination; phosphorylation LMO2(INDUCES) DNA(INDUCES) 15167914; 16858405 4 0 0 Phosphorylation and acetylation cause the degradation of acetylated GATA-1; DNA binding is required for MAPK-dependent phosphorylation +TLE1 TLE1 Nuclear receptor co-regulator; Transcription, coactivator/corepressor Q04724 7088 9q21.32 human S289-p 24987529 DASSSPAsTASSASS transcription, induced 24270405 1 2 0 +CREBBP CBP ACETYLTRANSFERASE; Acetyltransferase; DNA-binding; EC 2.3.1.48; Motility/polarity/chemotaxis; Nuclear receptor co-regulator; Transcription, coactivator/corepressor Q92793 1387 16p13.3 human S93-p 20615901 IGNVSASsPVQQGLG molecular association, regulation cell differentiation, inhibited; cell growth, induced CTNNB1(INDUCES) 21751375 1 1 0 +Nlrp3 NLRP3 Inhibitor Q8R4B8 216799 11|11 B1.3 mouse K687-ub 1881229503 GFFHNSPkEEEEERR activity, induced 33893171 1 0 0 inflammasome activation +IFNAR2 IFNAR2 Membrane protein, integral; Receptor, cytokine P48551 3455 21q22.11 human Y316-p 14574796 RKKKVWDyNYDDESD molecular association, regulation transcription, induced; signaling pathway regulation STAT2(DISRUPTS) 34813358 2 0 0 induces STAT phosphorylation and signaling +ALDH1B1 ALDH1B1 Amino Acid Metabolism - arginine and proline; Amino Acid Metabolism - histidine; Amino Acid Metabolism - lysine degradation; Amino Acid Metabolism - tryptophan; Amino Acid Metabolism - valine, leucine and isoleucine degradation; Carbohydrate Metabolism - ascorbate and aldarate; Carbohydrate Metabolism - butanoate; Carbohydrate Metabolism - glycolysis and gluconeogenesis; Carbohydrate Metabolism - propanoate; Carbohydrate Metabolism - pyruvate; EC 1.2.1.3; Lipid Metabolism - fatty acid; Lipid Metabolism - glycerolipid; Mitochondrial; Other Amino Acids Metabolism - beta-alanine; Oxidoreductase; Secondary Metabolites Metabolism - limonene and pinene degradation P30837 219 9p13.1 human K515-ub 1881380903 VTIKVPQkNS_____ molecular association, regulation transcription, inhibited ALDH1B1(DISRUPTS) 34769507 1 0 0 AMBRA1-mediated ubiquitylation of ALDH1B1 inhibitss the self-association of ALDH1B1 and the transcription of PTEN +ARHGAP22 ARHGAP22 GAP; GAP, Rac/Rho Q7Z5H3 58504 10q11.22-q11.23 human S14-p 25795201 RQARRARsKSLVMGE molecular association, regulation 14-3-3 beta(INDUCES) 22952583 1 1 0 +RELA NFkB-p65 DNA-binding; Nuclear receptor co-regulator; Transcription factor Q04206 5970 11q13.1 human K310-ac 459096 KRTYETFkSIMKKSP O-GlcNAc glycosylation; activity, induced; acetylation; protein stabilization; molecular association, regulation; methylation; intracellular localization carcinogenesis, induced; carcinogenesis, inhibited; cell motility, induced; transcription, induced; signaling pathway regulation; transcription, altered; cell growth, induced; apoptosis, inhibited; translation, induced; transcription, inhibited HDAC1(DISRUPTS); ARID4B iso2(DISRUPTS); BRD4(INDUCES) DNA(INDUCES); RNA(INDUCES) 12456660; 15152190; 16926151; 18223231; 18263619; 19103749; 19147572; 19345327; 20064247; 20160011; 20978007; 22205033; 23027940; 23075766; 23224434; 23686307; 24161395; 24189064; 24336331; 24396068; 26200012; 26411366; 27162363; 28416608; 28960214; 29158267; 30670829; 31285272; 32292498; 32416562; 32441762; 33510050; 35265200 84 5 0 +FRS2 FRS2 Adaptor/scaffold Q8WU20 10818 12q15 human Y306-p 449783 PSVNKLVyENINGLS molecular association, regulation cell differentiation, induced SOS1(INDUCES); GRB2(INDUCES) 11278583 3 14 216 +PIAS1 PIAS1 EC 6.3.2.-; Nuclear receptor co-regulator; SUMO LIGASE; SUMO conjugating system; SUMO ligase; Transcription, coactivator/corepressor O75925 8554 15q23 human S466-p 4700782 VIDLTIDsSSDEEEE molecular association, regulation transcription, inhibited SUMO2(INDUCES); SUMO1(INDUCES); UBC9(INDUCES) 19217413; 24174529 2 8 0 +MYLK smMLCK EC 2.7.11.18; KINASE; Kinase, protein; Protein kinase, CAMK; Protein kinase, Ser/Thr (non-receptor) Q15746 4638 3q21.1 human K608-ac 10769105 HEKKSSRkSEYLLPV enzymatic activity, inhibited carcinogenesis, inhibited; cell motility, inhibited 19826488 1 0 0 +MDM4 MDM4 EC 6.3.2.-; Ligase; UBIQUITIN LIGASE; Ubiquitin conjugating system; Ubiquitin ligase O15151 4194 1q32.1 human Y55-p 6039501 TVKEVMHyLGQYIMV SWIB molecular association, regulation; protein conformation 53BP1(INDUCES) 29348869 2 1 0 +Hdac7 HDAC7 DEACETYLASE; Deacetylase; EC 3.5.1.98; Hydrolase Q8C2B3 56233 15|15 F1 mouse S344-p 455621 RPLNRTRsEPLPPSA molecular association, regulation 14-3-3 epsilon(DISRUPTS) 16956611 5 16 18 +GAB2 GAB2 Adaptor/scaffold Q9UQC2 9846 11q14.1 human Y452-p 448384 STNSEDNyVPMNPGS molecular association, regulation PIK3R1(INDUCES) 11334882 6 3 29 +FOXM1 FOXM1 DNA-binding; Transcription factor Q08050 2305 12p13.33 human T611-p 451437 ETLPISStPSKSVLP molecular association, regulation; protein stabilization cell cycle regulation; transcription, induced CDC25A(INDUCES) 22094256; 23240008 4 3 3 +DNM1L DRP1 Apoptosis; EC 3.6.5.5; Endoplasmic reticulum; Hydrolase; Microtubule-binding; Mitochondrial; Motor O00429 10059 12p11.21 human K597-sm 9859925 RGMLKTSkAEELLAE activity, induced; intracellular localization 19638400 1 0 0 sumoylation is linked to its GTPase activity cycle, and influenced by DRP1 localization +NFATC4 NFAT3 DNA-binding; Transcription factor Q14934 4776 14q12 human S281-p 13419502 SGTPSSAsPALSRRG transcription, altered 17213202 1 1 2 +Oprk1 KOR-1 GPCR, family 1; Membrane protein, integral; Membrane protein, multi-pass; Receptor, GPCR P33534 18387 1 A1|1 1.89 cM mouse T357-p 52467201 MRMERQStNRVRNTV receptor internalization, induced; intracellular localization 26635353; 28893975 2 1 0 +Pdk1 PDHK1 EC 2.7.11.2; KINASE; Kinase, protein; Mitochondrial; Protein kinase, Ser/Thr (non-receptor); Protein kinase, atypical Q8BFP9 228026 2|2 C3 mouse Y242-p 465268 RRLCDLYyVNSPELE cell growth, induced 22195962 1 1 1 Y to F mutants show decreased proliferation under hypoxia and increased oxidative phosphorylation. +Srr SRR Amino Acid Metabolism - glycine, serine and threonine; EC 4.3.1.17; EC 4.3.1.18; EC 5.1.1.18; Isomerase Q9QZX7 27364 11|11 B5 mouse T71-p 14701400 IRGLIPDtPEEKPKA PALP enzymatic activity, induced 20493854 1 4 0 +ULK1 ULK1 Autophagy; EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, Other; Protein kinase, Ser/Thr (non-receptor) O75385 8408 12q24.33 human S1042-p 10428809 LCIERRLsALLTGIC DUF3543 protein degradation; molecular association, regulation autophagy, inhibited KLHL20(INDUCES) 26687681 1 3 0 +Spi1 PU.1 DNA-binding; Oncoprotein; Transcription factor P17433 20375 2 E1|2 50.44 cM mouse S41-p 13421401 DYYSFVGsDGESHSD RNA splicing, altered; transcription, altered 20190819 2 0 0 +Foxo3 FOXO3A Autophagy; DNA-binding; Oncoprotein; Transcription factor Q9WVH4 56484 10 B2|10 22.79 cM mouse S320-p 453424 NSNASTVsGRLSPIL intracellular localization cell cycle regulation; transcription, inhibited 12857750; 33530926 9 0 0 +HNRNPUL1 E1B-AP5 RNA splicing; RNA-binding Q9BUJ2 11100 19q13.2 human R618-m2 9481290 NRGGGGFrGRGGGGG molecular association, regulation; intracellular localization NBS1(INDUCES) 26020839 1 3 1 ecruitment at sites of damage +RPL11 RPL11 Motility/polarity/chemotaxis; Nucleolus; Ribosomal; Translation P62913 6135 1p36.11 human K169-ne 12067605 AMRWFQQkYDGIILP protein stabilization; intracellular localization 19713960 1 0 0 +PLEKHG6 PLEKHG6 GEF; GEF, Rac/Rho Q3KR16 55200 12p13.31 human T544-p 31834908 SPSTRPStPSLEGSQ molecular association, regulation; intracellular localization cell cycle regulation PLEKHG6(DISRUPTS); PLK1(INDUCES); RHOA(INDUCES) 24482237; 25336641 2 0 0 +SYK Syk EC 2.7.10.2; KINASE; Kinase, protein; Protein kinase, TK; Protein kinase, tyrosine (non-receptor) P43405 6850 9q22.2 human Y629-p 3656843 VELRLRNyYYDVVN_ enzymatic activity, altered transcription, altered 9624129 2 1 1 +GNG12 G-gamma 12 G protein; G protein, heterotrimeric; G protein, heterotrimeric gamma Q28024 286850 cow S3-p 447877 _____MSsKTASTNN cell adhesion, altered 11099498 1 1 0 +SMPD3 SMPD3 EC 3.1.4.12; Lipid Metabolism - sphingolipid; Membrane protein, integral; Phospholipase Q9NY59 55512 16q22.1 human S209-p 17547980 GSIKRTAsVEYKGDG protein stabilization 36261549 2 5 2 phosphorylation of SMPD3 S208 inhibits degradation of K103-mediated degradation of SMPD3 +Rps6kb1 p70S6K EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, AGC; Protein kinase, Ser/Thr (non-receptor); Translation Q8BSK8 72508 11|11 C mouse K508-ac 32640200 PNSGPYKkQAFPMIS cell growth, induced 27345368 3 0 0 +SYMPK Symplekin Motility/polarity/chemotaxis; RNA processing Q92797 8189 19q13.32 human K483-sm 2586341 PKEEKVVkTESVLIK RNA splicing, altered; cell growth, induced 17923699 1 1 0 regulation of mRNA 3'-end processing- cleavage and polyadenylation +H3C1 H3 DNA-binding P68431 8350 6p22.2 human R2-m2 4145503 ______ArTKQTARK Histone molecular association, regulation PHF21A(DISRUPTS); ING2(DISRUPTS); AIRE(DISRUPTS); RAG2(INDUCES) 20190764 6 0 0 +CFTR CFTR Channel, chloride; EC 3.6.3.49; Hydrolase; Membrane protein, integral; Membrane protein, multi-pass; Transporter; Transporter, ABC family P13569 1080 7q31.2 human S737-p 449981 EPLERRLsLVPDSEQ CFTR_R activity, induced; molecular association, regulation; enzymatic activity, inhibited; protein conformation; activity, inhibited endocytosis, induced CFTR(INDUCES) 11053017; 14602047; 1716180; 19095655; 19328185; 24727471; 26079370 18 9 1 attenuates CFTR-dependent iodide efflux via S737 phosphorylation; inhibits Cl- secretion +SMAD2 SMAD2 DNA-binding; Transcription factor Q15796 4087 18q21.1 human S255-p 448796 ELSPTTLsPVNHSLD activity, induced; protein stabilization; molecular association, regulation; intracellular localization; protein conformation cell differentiation, induced; cell motility, altered; transcription, induced SETD2(INDUCES); SMAD4(INDUCES) RNA(INDUCES) 10197981; 12193595; 19115199; 27153775; 31995604; 34504019 10 0 0 +MCL1 MCL1 Apoptosis; Channel, misc.; Inhibitor; Membrane protein, integral; Mitochondrial Q07820 4170 1q21.2 human S159-p 460683 NNTSTDGsLPSTPPP protein degradation; protein stabilization; molecular association, regulation; ubiquitination cell cycle regulation; carcinogenesis, induced; apoptosis, altered; carcinogenesis, inhibited; cell growth, inhibited; apoptosis, induced; cell growth, induced; apoptosis, inhibited FBXW7(INDUCES); USP9X(INDUCES); RICTOR(INDUCES); JOSD1(DISRUPTS) 16543145; 21368833; 21368834; 25918246; 26205817; 27738316; 28522751; 32081857; 33658484; 34758305; 36535926 17 7 2 +NUAK1 NuaK1 EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, CAMK; Protein kinase, Ser/Thr (non-receptor) O60285 9891 12q23.3 human S600-p 448726 PARQRIRsCVSAENF activity, induced cell motility, altered 12409306; 15060171 4 0 0 +KLF4 KLF4 C2H2-type zinc finger protein; DNA-binding; Transcription factor O43474 9314 9q31.2 human S234-p 31081924 GKFVLKAsLSAPGSE protein stabilization; molecular association, regulation; ubiquitination carcinogenesis, induced TRAF6(INDUCES) 31281496 1 2 0 +RPS6KB2 P70S6KB EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, AGC; Protein kinase, Ser/Thr (non-receptor); Translation Q9UBS0 6199 11q13.2 human S410-p 455989 SFQPKLRsPRRLNSS enzymatic activity, induced 11108720 2 0 3 +CBL CBL Adaptor/scaffold; EC 6.3.2.-; EC 6.3.2.19; Ligase; Motility/polarity/chemotaxis; Oncoprotein; UBIQUITIN LIGASE; Ubiquitin conjugating system; Ubiquitin ligase P22681 867 11q23.3 human S866-p 1868914506 SEIENLMsQGYSYQD UBA protein stabilization; phosphorylation; neddylation cell cycle regulation; DNA repair, induced; cell growth, inhibited; signaling pathway regulation 31315051 1 1 0 enhances TBRII neddylation, stabilization and signaling, induces SMAD2/3 phosphorylation +STK35 CLIK1 EC 2.7.11.1; KINASE; Kinase, protein; Nucleolus; Protein kinase, Other; Protein kinase, Ser/Thr (non-receptor) Q8TDR2 140901 20p13 human S385-p 27446434 KVADFGLsKVCAGLA Pkinase enzymatic activity, induced carcinogenesis, inhibited; cell growth, inhibited 35021089 1 3 0 +Prkcb PKCB iso2 EC 2.7.11.13; KINASE; Kinase, protein; Motility/polarity/chemotaxis; Protein kinase, AGC; Protein kinase, Ser/Thr (non-receptor) P68404-2 18751 7 F2|7 65.75 cM mouse T634-p 448592 ENFDRFFtRHPPVLT Pkinase_C molecular association, regulation; protein conformation; phosphorylation; enzymatic activity, induced PKCB iso2(DISRUPTS) 33850054 2 1 3 induces phosphorylation at S660 +LEO1 LEO1 Transcription regulation Q8WVC0 123169 15q21.2 human S110-p 55377670 DVDQHSGsEAPNDDE molecular association, regulation; intracellular localization carcinogenesis, inhibited; cell growth, inhibited; apoptosis, induced; transcription, inhibited; signaling pathway regulation CTNNB1(DISRUPTS) 30305722 1 2 0 +IL24 IL24 Motility/polarity/chemotaxis; Secreted; Secreted, signal peptide Q13007 11009 1q32.1 human T111-p 41122603 ESCYLVHtLLEFYLK activity, induced; intracellular localization cell cycle regulation; carcinogenesis, inhibited; cell growth, inhibited; cell motility, inhibited; signaling pathway regulation 26009991 1 0 0 IL24 maturation and secretion; activates Caspase-9, PARP, and JNK; inhibits the AKT signaling pathway +KCNQ1 Kv7.1 Channel, potassium; Membrane protein, integral; Membrane protein, multi-pass P51787 3784 11p15.5-p15.4 human T96-p 23120471 PRVSIYStRRPVLAR activity, inhibited 29452158 1 0 1 mediate the inhibition of Ang II on the current +SQSTM1 SQSTM1 Autophagy; Nuclear receptor co-regulator; Ubiquitin conjugating system Q13501 8878 5q35.3 human S349-p 14580829 SSKEVDPsTGELQSL activity, induced; protein stabilization; molecular association, regulation; intracellular localization; protein conformation autophagy, induced; cell growth, induced; apoptosis, inhibited; transcription, induced; autophagy, inhibited; signaling pathway regulation; transcription, inhibited KEAP1(INDUCES) 24886973; 25505069; 27245349; 27846364; 28846113; 30533198; 31444413; 31586112; 32835772; 34405859; 34774801; 34774851; 34838592; 36008391; 36165926; 37306101 48 0 1 regulates the KEAP1-NRF2 pathway.; abolishes oxidative stress through the mTOR/SQSTM1/Keap1/Nrf2 pathway; regulates NRF2 signaling +Snca SNCA Adaptor/scaffold O55042 20617 6 B3|6 29.15 cM mouse T64-p 1876998407 EKTKEQVtNVGGAVV Synuclein molecular association, regulation; intracellular localization transcription, altered SNCA(DISRUPTS) 37252975 1 2 0 +EPHB4 EphB4 EC 2.7.10.1; KINASE; Kinase, protein; Membrane protein, integral; Protein kinase, TK; Protein kinase, tyrosine (receptor) P54760 2050 7q22.1 human Y590-p 450854 IGHGTKVyIDPFTYE EphA2_TM molecular association, regulation; enzymatic activity, induced cell growth, induced RASA1(INDUCES) 11929761; 37507023 2 20 154 +S1PR1 EDG-1 GPCR, family 1; Membrane protein, integral; Membrane protein, multi-pass; Receptor, GPCR P21453 1901 1p21.2 human Y143-p 38535267 LAIAIERyITMLKMK 7tm_1 receptor internalization, induced 25588843 1 0 0 +Fcrl1 FCRL1 Membrane protein, integral Q8R4Y0 229499 3|3 F1 mouse Y281-p 25738355 SRQPEPLyENVNVVS molecular association, regulation; phosphorylation signaling pathway regulation GRB2(INDUCES) 34697226 1 1 3 inhibits ERK phosphorylation; regulates the BCR signaling pathway +RPS6KA6 RSK4 EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, AGC; Protein kinase, Ser/Thr (non-receptor) Q9UK32 27330 Xq21.1 human T581-p 4045800 GENGLLLtPCYTANF Pkinase phosphorylation; enzymatic activity, induced 15632195 1 0 0 phosphorylation of S389 +CACNA1H CACNA1H Cell development/differentiation; Channel, calcium; Membrane protein, integral; Membrane protein, multi-pass O95180 8912 16p13.3 human S1107-p 6729300 LPDSRRGsSSSGDPP activity, inhibited 19131331 2 0 0 +KIF11 KIF11 Microtubule-binding; Motor P52732 3832 10q23.33 human K771-ac 1876332700 KMTFHSQkFCADSDG protein stabilization; ubiquitination; intracellular localization; phosphorylation cell cycle regulation; carcinogenesis, induced; cell growth, induced 35210604 1 0 0 inhibits ubiquitination and primes phosphorylation at T926 +CFTR CFTR Channel, chloride; EC 3.6.3.49; Hydrolase; Membrane protein, integral; Membrane protein, multi-pass; Transporter; Transporter, ABC family P13569 1080 7q31.2 human S712-p 455297 INSIRKFsIVQKTPL CFTR_R molecular association, regulation; enzymatic activity, inhibited CFTR(INDUCES) 14602047 4 6 0 +Abhd5 ABHD5 EC 2.3.1.51; Lipase; Transferase Q9DBL9 67469 9|9 F4 mouse S239-p 36744500 PDFKRKYsSMFEDDT intracellular localization 25421061 2 1 0 PKA-mediated phosphorylation of CGI-58 (ABHD5) leads to CGI-58 dispersion into the cytoplasm. +PKN2 PKN2 EC 2.7.11.13; KINASE; Kinase, protein; Protein kinase, AGC; Protein kinase, Ser/Thr (non-receptor) Q16513 5586 1p22.2 human T958-p 2509079 TSEAPILtPPREPRI Pkinase_C molecular association, regulation; enzymatic activity, inhibited; protein conformation; phosphorylation; enzymatic activity, induced signaling pathway regulation 14-3-3 beta(INDUCES); PDK1(DISRUPTS) 17446865; 19723632; 31451768 3 52 17 mTORC1-mediated nutrient signaling +FOXO3 FOXO3A Autophagy; DNA-binding; Oncoprotein; Transcription factor O43524 2309 6q21 human S626-p 20799905 SLECDMEsIIRSELM FOXO-TAD molecular association, regulation; phosphorylation transcription, induced CBP(INDUCES) 17711846; 22474372 3 1 0 +PDE3A PDE3A EC 3.1.4.17; Membrane protein, integral; Membrane protein, multi-pass; Nucleotide Metabolism - purine; Phosphodiesterase Q14432 5139 12p12.2 human S293-p 471416 FKRRRRSsSVVSAEM molecular association, regulation; enzymatic activity, induced SERCA2(INDUCES); AKAP7(NOT_REPORTED) 25593322 2 2 9 +Grm3 mGluR3 GPCR, family 3; Membrane protein, integral; Membrane protein, multi-pass; Receptor, GPCR P31422 24416 4q12 rat S845-p 450252 RLHLNRFsVSGTATT molecular association, regulation PPPM1A(DISRUPTS) 14663150 1 0 0 +OSBP OSBP Lipid-binding P16258 rabbit S200-p 484803 DESGDEEsVSQTDKT molecular association, regulation; intracellular localization VAPA(INDUCES) 22875984 1 9 1 regulation of Sphingomyelin synthesis. S381A/S3D mutant has enhanced binding and altered localization +PKD2L1 PKD2L1 Channel, cation; Membrane protein, integral; Membrane protein, multi-pass; Motility/polarity/chemotaxis Q9P0L9 9033 10q24.31 human S685-p 394791405 KLGRSIVsSPQGKSG activity, induced 29230552 1 0 0 regulates the channel activity +USP25 USP25 DEUBIQUITINASE; EC 3.4.19.12; Protease; Ubiquitin conjugating system; Ubiquitin-specific protease Q9UHP3 29761 21q21.1 human T680-p 27533602 QPLVGIEtLPPDLRD ubiquitination; enzymatic activity, inhibited 25755282 1 1 0 in vitro deubiquitination assays +Dmbt1 DMBT1 Membrane protein, integral; Oncoprotein; Secreted; Secreted, signal peptide; Tumor suppressor Q60997 12945 7|7 F3 mouse S2082-p 13201903 IDRGQPPsTKL____ molecular association, regulation exocytosis, altered; cytoskeletal reorganization NHERF(INDUCES); ACTB(INDUCES) 15146979 1 0 0 Phosphomimetic peptides associate with the cytoskeleton, though not binding directly to actin. +Lrrk2 LRRK2 EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, Ser/Thr (non-receptor); Protein kinase, TKL Q5S006 66725 15|15 E3 mouse S935-p 4725898 NAQRHSNsLGPVFDH molecular association, regulation; enzymatic activity, inhibited; enzymatic activity, induced; phosphorylation autophagy, induced 14-3-3 beta(INDUCES); 14-3-3 theta(INDUCES); 14-3-3 zeta(INDUCES); 14-3-3 epsilon(INDUCES); 14-3-3 gamma(INDUCES); 14-3-3 eta(INDUCES) 20642453; 20659021; 21390248; 33055242; 34871735; 37454104 43 17 2 +HSP90AA1 HSP90A Chaperone; Heat shock protein P07900 3320 14q32.31 human Y627-p 462281 RDNSTMGyMAAKKHL HSP90 molecular association, regulation PPP5C(DISRUPTS) 22727666 1 8 89 +Dync1i2 DYNC1I2 Microtubule-binding; Motility/polarity/chemotaxis; Motor O88487 13427 2 C2|2 42.38 cM mouse S81-p 449148 PIVPPPMsPSSKSVS cell motility, induced 32554528 2 26 2 regulates dynein function; neuronal migration +MAPT Tau iso3 ACETYLTRANSFERASE; Acetyltransferase; Cytoskeletal P10636-3 4137 17q21.31 human T137-p 449079 KKVAVVRtPPKSPSS molecular association, regulation cytoskeletal reorganization 10747907 149 48 14 regulates association with membrane +PNKP Pnk1 DNA-binding; EC 2.7.1.78; EC 3.1.3.32; Kinase, other; Phosphatase (non-protein) Q96T60 11284 19q13.33 human S114-p 460832 EETRTPEsQPDTPPG molecular association, regulation; enzymatic activity, inhibited; intracellular localization; enzymatic activity, induced DNA repair, induced DNA(INDUCES) 21637298; 21824916 2 18 31 +MCF2 MCF2 Apoptosis; Cell development/differentiation; GEF; GEF, Rac/Rho; Motility/polarity/chemotaxis; Oncoprotein P10911 4168 Xq27.1 human Y510-p 33402206 LIQTERVyVRELYTV RhoGEF activity, induced; molecular association, regulation; intracellular localization cytoskeletal reorganization GRB2(INDUCES); CDC42(INDUCES); RHOA(INDUCES) 24778185 1 0 0 RhoA-GTPases activity induced transcriptional activation of NFkB +SYK Syk EC 2.7.10.2; KINASE; Kinase, protein; Protein kinase, TK; Protein kinase, tyrosine (non-receptor) P43405 6850 9q22.2 human Y323-p 447658 STVSFNPyEPELAPW molecular association, regulation; enzymatic activity, induced Fyn(INDUCES); CBL(INDUCES) 9535867 21 30 1019 +PKM PKM Carbohydrate Metabolism - glycolysis and gluconeogenesis; Carbohydrate Metabolism - pyruvate; EC 2.7.1.40; KINASE; Kinase, other; Mitochondrial; Nucleotide Metabolism - purine P14618 5315 15q23 human K186-ub 12393391 GLISLQVkQKGADFL PK enzymatic activity, inhibited carcinogenesis, inhibited; cell growth, inhibited 26975375 1 3 2 +FOXO3 FOXO3A Autophagy; DNA-binding; Oncoprotein; Transcription factor O43524 2309 6q21 human K290-ac 460596 DSPSQLSkWPGSPTS protein stabilization; molecular association, regulation; ubiquitination; intracellular localization apoptosis, induced; transcription, induced JNK1(INDUCES); SKP2(DISRUPTS) 21841822; 25981116; 27669435 5 0 0 +MEX3B RKHD3 RNA-binding; Ubiquitin conjugating system Q6ZN04 84206 15q25.2 human S462-p 4668104 HLARRVRsDPGGGGL protein stabilization; molecular association, regulation; intracellular localization 14-3-3 eta(INDUCES) 18779327 1 0 0 +CNN1 calponin 1 Actin-binding; Contractile; Motility/polarity/chemotaxis; Myosin-binding Q08092 396911 pig S175-p 450890 MGTNKFAsQQGMTAY Calponin activity, induced 9851593 3 2 0 Phosphorylation of calponin at S175 may play a role in vasoconstriction. +LIG1 LIG1 DNA repair, damage; EC 6.5.1.1; Ligase P18858 3978 19q13.33 human S51-p 468123 GVVSESDsPVKRPGR molecular association, regulation; intracellular localization cell cycle regulation; cytoskeletal reorganization; DNA repair, inhibited; cell growth, altered RFC1(INDUCES); RAD17(DISRUPTS); RFC1(DISRUPTS) 12851383; 19223468; 22952233 3 56 8 S51D mutant induces cellular senescence ; regulates DNA replication and repair +CACNA1C CACNA1C Channel, calcium; Membrane protein, integral; Membrane protein, multi-pass BAA34185.2 guinea pig S1574-p 467228 VACKRLVsMNMPLNS GPHH activity, induced; molecular association, regulation; protein conformation Calmodulin(DISRUPTS) 25209265; 30042022 4 0 0 +TRPV6 TRPV6 Channel, calcium; Membrane protein, integral; Membrane protein, multi-pass Q9H1D0 55503 7q34 human S184-p 12173901 LARRASVsARATGTA Ank_2 activity, inhibited 19805577 1 0 0 involved in regulation of calcium influx by ATP +Gys2 GYS2 Carbohydrate Metabolism - starch and sucrose; Cytoskeletal; EC 2.4.1.11; Transferase P17625 25623 4q44 rat S641-p 7390700 FKYPRPSsVPPSPSG Glycogen_syn phosphorylation 19124463 1 0 0 S641A mutant caused decrease in S645 phosphorylation +DIAPH1 Diaphanous-1 Actin-binding; Adaptor/scaffold; Motility/polarity/chemotaxis O60610 1729 5q31.3 human T768-p 3946102 PVLPFGLtPKKLYKP protein degradation; molecular association, regulation KIF1A(INDUCES); ACTB(INDUCES) 23325789 2 1 0 induces sumoylation; modulates mitochondrial movement +Hmgcs2 HMGCS2 Amino Acid Metabolism - valine, leucine and isoleucine degradation; Carbohydrate Metabolism - butanoate; EC 2.3.3.10; Lipid Metabolism - synthesis and degradation of ketone bodies; Mitochondrial; Secondary Metabolites Metabolism - terpenoid backbone biosynthesis; Transferase P54869 15360 3 F2.2|3 42.74 cM mouse K83-sc 33344864 FNNVEAGkYTVGLGQ HMG_CoA_synt_N enzymatic activity, inhibited 24315375 0 2 0 K83E or K310E mutants lose enzymatic activity +Akt1 Akt1 EC 2.7.11.1; KINASE; Kinase, protein; Oncoprotein; Protein kinase, AGC; Protein kinase, Ser/Thr (non-receptor) P47196 24185 6q32 rat S473-gl 4261200 RPHFPQFsYSASGTA Pkinase_C phosphorylation 18570920 5 0 0 O-GlcNAc modification at Akt S473 competes with phosphorylation at Akt S473 +Gata6 GATA6 Motility/polarity/chemotaxis; Transcription factor Q61169 14465 18 A1|18 5.63 cM mouse S264-p 2833503 ASARFPYsPSPPMAN GATA-N cell differentiation, induced; transcription, induced 29454706 2 3 3 +BCAR1 P130Cas Adaptor/scaffold; Motility/polarity/chemotaxis P56945 9564 16q23.1 human S139-p 483627 GPSPQFQsPPAKQTS intracellular localization cell motility, altered 19454314 1 17 8 +NFE2L2 NRF2 DNA-binding; Transcription factor Q16236 4780 2q31.2 human K554-ac 7106311 DKSLHLLkKQLSTLY bZIP_Maf molecular association, regulation transcription, induced DNA(INDUCES) 19273602 1 1 0 +STAT4 STAT4 DNA-binding; Transcription factor Q14765 6775 2q32.2-q32.3 human K667-ac 1878023503 YLYPDIPkDKAFGKH intracellular localization; phosphorylation cell differentiation, induced JAK2(INDUCES) 35614130 1 1 0 nuclear translocation, required for JAK2-STAT4 complex formation +MTA1 MTA1 Motility/polarity/chemotaxis; Nuclear receptor co-regulator; Transcription, coactivator/corepressor Q13330 9112 14q32.33 human K626-ac 460693 RNLLLNGkSYPTKVR molecular association, regulation; intracellular localization transcription, induced POLR2A(INDUCES) 16617102 2 0 0 MTA1 colocalizes with acetyl-He and interacts with RNA Pol II complex and recruits complex to the BCAS3 enhancer +Pparg PPAR-gamma DNA-binding; Nuclear receptor; Transcription factor P37238 19016 6 E3|6 53.41 cM mouse S273-p 15175800 TGKTTDKsPFVIYDM activity, induced; molecular association, regulation cell differentiation, inhibited; translation, altered; transcription, inhibited; transcription, altered Trap150(INDUCES) 20651683; 25409143; 30008738; 34431242; 34526909; 37230992 26 2 0 +ACAP1 CENTB1 GAP; GAP, ARF; Motility/polarity/chemotaxis Q15027 9744 17p13.1 human S554-p 458238 SIRPRPGsLRSKPEP molecular association, regulation cell motility, altered ITGB1(INDUCES) 16256741 2 2 2 +USP2 USP2 DEUBIQUITINASE; EC 3.4.19.12; Protease; Ubiquitin-specific protease O75604 9099 11q23.3 human S225-p 803501401 SRVPEIIsPTYRPIG molecular association, regulation 29490279 1 1 0 disassociation of phosphorylated R-SMADs from the receptor complex; USP2a promotes TGF-beta-induced EMT and metastasis +Notch3 NOTCH3 Membrane protein, integral Q61982 18131 17 B1|17 17.37 cM mouse K1731-ac 31089504 DSECPEAkRLKVEEP protein degradation; ubiquitination carcinogenesis, inhibited; cell growth, inhibited; transcription, inhibited; signaling pathway regulation 22120716 1 1 0 +E2F1 E2F1 DNA-binding; Transcription factor Q01094 1869 20q11.22 human S375-p 3193946 PVDEDRLsPLVAADS molecular association, regulation; protein conformation cell cycle regulation; transcription, inhibited; transcription, altered; cell growth, altered PRB1(INDUCES) DNA(DISRUPTS) 20616879; 22945643; 37467925 4 13 0 +Brca1 BRCA1 EC 6.3.2.-; Nuclear receptor co-regulator; Transcription, coactivator/corepressor; Tumor suppressor; UBIQUITIN LIGASE; Ubiquitin conjugating system; Ubiquitin ligase P48754 12189 11 65.18 cM|11 D mouse S1152-p 450007 LRRESSRsPSPVTHA molecular association, regulation; ubiquitination; intracellular localization; phosphorylation; enzymatic activity, induced DNA repair, induced; apoptosis, altered SKP2(INDUCES); NBS1(INDUCES) 19996295; 36065181 6 15 6 induces CHK1-S345 and RPA2-S4/8 10 phosphorylation and NBS1 ubiquitination; confers resistance to gamma-radiation by preventing radiation-induced apoptosis; required for proper skin structure and hair regeneration; recruits ATM to DSBs; required for tumor prevention +Stxbp3 STXBP3 Vesicle Q60770 20912 3|3 F3 mouse Y521-p 459181 RQKPRTNyLELDRKN Sec1 molecular association, regulation; intracellular localization exocytosis, induced STX4(DISRUPTS); VAMP2(DISRUPTS) 17916632; 21444687; 21548926; 23937695 5 8 68 GLUT4 vesicle exocytosis induced; Munc18c dissociation from syntaxin 4; 2-deoxy-glucose uptake in adipocytes +Smpd3 SMPD3 EC 3.1.4.12; Lipid Metabolism - sphingolipid; Membrane protein, integral; Phospholipase Q9JJY3 58994 8|8 D3 mouse S208-p 17547980 GSIKRTAsVEYKGDG protein stabilization 22074919; 36261549 2 5 2 phosphorylation of SMPD3 S208 inhibits degradation of K103-mediated degradation of SMPD3 +Zap70 ZAP70 EC 2.7.10.2; KINASE; Kinase, protein; Protein kinase, TK; Protein kinase, tyrosine (non-receptor) P43404 22637 1 B|1 15.41 cM mouse Y290-p 447586 DTLNSDGyTPEPARL signaling pathway regulation 34452999 10 14 447 regulates TCR signaling +Gria1 GluR1 Channel, calcium; Channel, ligand-gated; Membrane protein, integral; Membrane protein, multi-pass P19490 50592 10q22 rat K886-ub 40320201 VVSQDFPkSMQSIPC protein degradation; intracellular localization 25660027 3 0 0 +Nr3c2 MCR DNA-binding; Nuclear receptor Q8VII8 110784 8 C1|8 36.34 cM mouse S837-p 29669801 NEEKMHQsAMYELCQ Hormone_recep molecular association, regulation; intracellular localization transcription, inhibited SRC-1(DISRUPTS) 27422824 3 2 0 decreased nuclear localization +RPTOR Raptor Adaptor/scaffold Q8N122 57521 17q25.3 human S696-p 11315003 EKNYALPsPATTEGG enzymatic activity, induced; phosphorylation 21325048; 22493283 8 11 1 mutation of S696A interferes with the insulin-stimulated phosphorylation of p70S6K; mTORC1 activity induced +RIPK1 RIPK1 EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, Ser/Thr (non-receptor); Protein kinase, TKL Q13546 8737 6p25.2 human S166-p 27116401 LASFKMWsKLNNEEH PK_Tyr_Ser-Thr molecular association, regulation; enzymatic activity, inhibited; enzymatic activity, induced; phosphorylation apoptosis, induced FADD(INDUCES); CASP8(INDUCES) 33469115; 34965934; 35256774; 36356302 36 2 0 +TTK TTK Cancer Testis Antigen (CTA); EC 2.7.12.1; KINASE; Kinase, protein; Protein kinase, Other; Protein kinase, dual-specificity (non-receptor) P33981 7272 6q14.1 human K827-ub 21187456 NSPNSILkAAKTLYE protein degradation cell cycle regulation 34586601 1 3 0 +UIMC1 RAP80 Nuclear receptor co-regulator; Transcription, coactivator/corepressor Q96RL1 51720 5q35.2 human S677-p 453731 TRRDLNEsPVKSFVS cell cycle regulation; DNA repair, altered 23264621 1 32 3 regulates sensitivity to ionizing radiation +Mvk MVK EC 2.7.1.36; Kinase, other; RNA-binding; Secondary Metabolites Metabolism - terpenoid backbone biosynthesis; Translation P17256 rat K345-sm 12723515 GCGITLLkPGLERAK GHMP_kinases_C translation, inhibited 20167237 1 0 0 +SLC9A5 NHE5 Membrane protein, integral; Membrane protein, multi-pass; Transporter; Transporter, SLC family Q14940 6553 16q22.1 human S702-p 20832300 AVILTVEsEEEEEES molecular association, regulation; activity, inhibited endocytosis, induced ARRB1(INDUCES) 21296876 1 0 0 +PRPF19 PRPF19 EC 6.3.2.-; EC 6.3.2.19; Ligase; RNA splicing; Spliceosome; UBIQUITIN LIGASE; Ubiquitin conjugating system; Ubiquitin ligase Q9UMS4 27339 11q12.2 human T193-p 17331800 ERKKRGKtVPEELVK molecular association, regulation; intracellular localization 14-3-3 beta(INDUCES); CDC5L(INDUCES) 20629186 1 0 0 involved in neuronal differentiation +LMNB1 Lamin B1 Cytoskeletal P20700 4001 5q23.2 human S405-p 448733 VTVSRASsSRSVRTT cell cycle regulation 8663071 3 12 94 +SLAMF6 SLAMF6 Membrane protein, integral; Receptor, misc. Q96DU3 114836 1q23.2-q23.3 human Y285-p 457709 SPTNNTVyASVTHSN molecular association, regulation Lck(INDUCES); SH2D1A(INDUCES) 24688028 2 4 188 +Slc2a1 GLUT1 Membrane protein, integral; Membrane protein, multi-pass; Transporter; Transporter, SLC family P17809 20525 4 D2.1|4 55.34 cM mouse T478-p 4148989 GASQSDKtPEELFHP protein degradation; molecular association, regulation; ubiquitination apoptosis, inhibited TRIM21(INDUCES) 35483524 1 12 2 +Nfatc2 NFAT1 DNA-binding; Transcription factor Q60591 18019 2 H3|2 88.91 cM mouse S174-p 447841 LCLSPASsGSSASFI transcription, inhibited 11030334 0 1 0 +ID3 ID3 DNA-binding; Transcription, coactivator/corepressor Q02535 3399 1p36.12 human S18-p 25295708 YEAVCCLsERSLAIA protein stabilization 25090023 1 2 1 regulates vascular EC survival and growth of microvascular lesions +BACH2 BACH2 DNA-binding; Transcription factor Q9BYV9 60468 6q15 human S520-p 53354442 LETRTRTsSSCSSYS intracellular localization transcription, induced 36448459 1 1 0 +LDB1 LDB1 Transcription, coactivator/corepressor Q86U70 8861 10q24.32 human K170-ub 14512104 SMVTQHGkPMFTQVC LIM_bind protein degradation; protein stabilization 20423330 2 0 0 differential regulation of protein expression-mono-ubiquitination promotes stabilization, poly-ubiquitination induces degradation +Grin2b NMDAR2B Channel, calcium; Channel, ligand-gated; Membrane protein, integral; Membrane protein, multi-pass Q00960 24410 4q43 rat S1166-p 481156 SDDFKRDsVSGGGPC NMDAR2_C activity, induced; receptor desensitization, inhibited; receptor inactivation, inhibited 24431445; 24847051 3 2 1 NMDAR potentiation and Ca2+ signaling in spines; enhanced receptor gating +H1-4 H1E DNA-binding P10412 3008 6p22.2 human K26-me 2303905 PVKKKARkSAGAAKR molecular association, regulation HP1 alpha(INDUCES); CBX3(INDUCES); CBX1(INDUCES) 16127177 2 1 0 +DVL2 DVL2 Adaptor/scaffold; Motility/polarity/chemotaxis O14641 1856 17p13.1 human K477-ub 610815806 PERREARkYASGLLK DEP molecular association, regulation; intracellular localization cell motility, induced; signaling pathway regulation Cofilin-1(INDUCES); VANGL1(INDUCES) 31340145 1 3 0 DVL2 variant with all encoded lysine residues mutated to arginine is sufficient to restore WNT activation +NOTCH1 Notch 1 Membrane protein, integral; Motility/polarity/chemotaxis; Oncoprotein; Receptor, misc.; Transcription factor P46531 4851 9q34.3 human K2160-ac 18899502 VQGKKVRkPSSKGLA intracellular localization cell growth, induced; apoptosis, inhibited 28377411 2 1 0 +CERT1 COL4A3BP EC 2.7.11.9; KINASE; Kinase, protein; Lipid-binding; Protein kinase, Ser/Thr (non-receptor); Protein kinase, atypical Q9Y5P4 10087 5q13.3 human S138-p 4777479 GSMVSLVsGASGYSA molecular association, regulation; activity, inhibited 28652409 0 1 0 reduced PtdIns(4)P binding affinity as well as low ceramide transfer activity, E494R/N495K/P535R/E537K mutations, recovery of both PtdIns(4)P binding and ceramide transfer activity. +SETDB1 SETDB1 Amino Acid Metabolism - lysine degradation; EC 2.1.1.43; METHYLTRANSFERASE; Methyltransferase; Methyltransferase, protein lysine Q15047 9869 1q21.3 human K867-ub 56394103 IESVENFkEGYESDA SET methylation; enzymatic activity, induced 27237050; 27798683 3 3 0 induces H3K9 methyltransferase activity +TP73 p73 DNA-binding; Transcription factor; Tumor suppressor O15350 7161 1p36.32 human K321-ac 460605 ALNESSAkNGAASKR molecular association, regulation cell growth, inhibited; apoptosis, induced; transcription, induced DNA(INDUCES) 11804596 1 1 0 induces binding to p53AIP1 gene and induces its transcription, but retains an intact ability to regulate genes. +Brsk2 BRSK2 EC 2.7.11.1; EC 2.7.11.26; KINASE; Kinase, protein; Protein kinase, CAMK; Protein kinase, Ser/Thr (non-receptor) Q69Z98 75770 7|7 F5 mouse S424-p 2085944 ASSGLSTsPLSSPRV protein stabilization; enzymatic activity, inhibited; phosphorylation 23790753 1 17 0 inhibits axon branching (activated in BRSK2 18A mutant) +CSF2RB CSF2RB Membrane protein, integral; Receptor, cytokine P32927 1439 22q12.3 human Y628-p 450121 PPPGSLEyLCLPAGG activity, induced; molecular association, regulation; phosphorylation apoptosis, altered; cell motility, altered; transcription, altered; cell growth, altered GRB2(INDUCES); SHC1(INDUCES); SHP-2(INDUCES) 10329850; 10672044; 10704825; 10760518; 9257712 6 0 0 Phosphorylation of Y628, Y711, or Y766 is necessary and sufficient for STAT activation by IL-5. +PINK1 PINK1 EC 2.7.11.1; KINASE; Kinase, protein; Membrane protein, integral; Mitochondrial; Protein kinase, Other; Protein kinase, Ser/Thr (non-receptor) Q9BXM7 65018 1p36.12 human K433-ub 40212809 RAVIDYSkADAWAVG Pkinase protein stabilization; molecular association, regulation TOM20(INDUCES) 23885119 1 0 0 +SUPT5H SPT5 RNA-binding; Transcription, coactivator/corepressor O00267 6829 19q13.2 human T775-p 458815 TPMYGSQtPMYGSGS transcription, induced; transcription, altered 10757782; 16427012 3 6 38 required for c-fos induction and activation in vivo +SSRP1 SSRP1 Nucleolus; RNA-binding; Transcription initiation complex; Transcription, coactivator/corepressor Q08945 6749 11q12.1 human K143-m1 58123206 VSQCTTGkNEVTLEF SSrecog molecular association, regulation L3MBTL iso4(INDUCES) 23583077 0 1 0 +Rab3il1 RAB3IL1 GEF; GEF, Rab Q99NH3 171452 1q43 rat S169-p 467058 VITSTPAsPNRELHP Sec2p activity, inhibited cell motility, induced; cytoskeletal reorganization 28123016 2 21 35 suppresses RAB3IL1 GEF activity; regulates axonal outgrowth +EPB41 EPB41 iso4 Cytoskeletal P11171-4 2035 1p35.3 human Y13-p 463285 SLLDDTVyECVVEKH FERM_N cytoskeletal reorganization 20206558 1 5 46 +ODF2 ODF2 iso3 Cancer Testis Antigen (CTA); Cytoskeletal Q5BJF6-3 4957 9q34.11 human S796-p 449230 YSTFLTSsPIRSRSP molecular association, regulation cytoskeletal reorganization PLK1(INDUCES) 19386263 1 9 0 +CALD1 Caldesmon Actin-binding P12957 373965 chicken S615-p 2873302 RAEFLNKsAQKSGMK Caldesmon molecular association, regulation ACTB(NOT_REPORTED) 8182108 1 12 0 +Ptprh PTPRH EC 3.1.3.48; Membrane protein, integral; Motility/polarity/chemotaxis; PHOSPHATASE; Receptor protein phosphatase, tyrosine E9Q0N2 545902 7|7 A1 mouse Y953-p 10804386 ENVASLVyENASAIM molecular association, regulation cytoskeletal reorganization GRB2(INDUCES); Fyn(INDUCES) 20398064 1 1 1 +L1cam NCAM-L1 Cell adhesion; Membrane protein, integral Q05695 50687 Xq37 rat Y1178-p 456529 KDETFGEyRSLESDN Bravo_FIGEY molecular association, regulation; intracellular localization Ezrin(DISRUPTS); SNAP-91(DISRUPTS); AP2M1(DISRUPTS) 15911348; 18478542 12 3 10 +XRCC1 XRCC1 DNA repair, damage P18887 7515 19q13.31 human S410-p 3181465 MAGPGSSsEEDEASH molecular association, regulation PARP1(DISRUPTS) 25477519 2 5 0 +Syne1 SYNE1 Actin-binding; Membrane protein, integral; RNA-binding Q6ZWR6 64009 10|10 A1 mouse S1366-p 30310303 SSHERFLsFSSLESL receptor internalization, induced; molecular association, regulation; intracellular localization cytoskeletal reorganization ACTB(INDUCES) 24191017 1 1 0 localization to dendritic spines, GluA2 internalization +SHC1 SHC1 Adaptor/scaffold; Apoptosis; Mitochondrial; Motility/polarity/chemotaxis P29353 6464 1q21.3 human Y350-p 448510 EPPDHQYyNDFPGKE molecular association, regulation apoptosis, altered; apoptosis, inhibited GRB2(INDUCES) 15688026; 8939605; 8947042 29 22 943 +EIF4G1 eIF4G iso8 RNA-binding; Translation; Translation initiation Q04637-8 1981 3q27.1 human S1093-p 3194291 FAPGGRLsWGKGSSG molecular association, regulation; protein conformation transcription, induced; translation, induced; signaling pathway regulation eIF3-alpha(DISRUPTS); eIF3-theta(INDUCES) 30012863; 30012864 2 49 2 PKC-Raf-ERK signaling +DEPTOR DEPTOR Apoptosis Q8TB45 64798 8q24.12 human S235-p 4723788 MELLNEKsPSSQETH protein stabilization; molecular association, regulation; ubiquitination; phosphorylation carcinogenesis, induced USP7(INDUCES) 35216969 2 12 1 +Map1lc3b LC3B Autophagy; Microtubule-binding; Ubiquitin-like modifier; Vesicle Q9CQV6 67443 8|8 E1 mouse T50-p 37045604 QLPVLDKtKFLVPDH ATG8 autophagy, induced 25544559 3 1 0 induces fusion of autophagosomes with lysosomes and autophagy-mediated pathogen clearance +Crebbp CBP ACETYLTRANSFERASE; Acetyltransferase; DNA-binding; EC 2.3.1.48; Motility/polarity/chemotaxis; Nuclear receptor co-regulator; Transcription, coactivator/corepressor P45481 12914 16 A1|16 2.4 cM mouse R624-me 1280604 PAALKDRrMENLVAY KIX molecular association, regulation CREB(DISRUPTS) 11701890 1 0 0 +ABRAXAS2 ABRAXAS2 Ubiquitin conjugating system Q15018 23172 10q26.13 human Y377-p 3196742 EDSDDSDyENLIDPT molecular association, regulation LNK(INDUCES) 30755420 1 4 4 interaction with LNK further regulates LNK interaction with BRISC +Etv4 ETV4 DNA-binding P28322 18612 11 D|11 65.48 cM mouse K95-sm 3144816 HSPTTRIkKEPQSPR ETS_PEA3_N protein degradation; ubiquitination transcription, induced; transcription, inhibited 18447755; 19307308 4 1 0 +DAB2IP DAB2IP GAP; GAP, Ras; Tumor suppressor Q5VWQ8 153090 9q33.2 human S728-p 478274 PSPARSSsYSEANEP DUF3498 molecular association, regulation apoptosis, induced; transcription, altered 14-3-3 beta(INDUCES); ASK1(INDUCES); RIPK1(INDUCES); TRAF2(INDUCES) 17389591 1 1 1 +GRIK1 GluR5 iso2 Channel, ligand-gated; Membrane protein, integral; Membrane protein, multi-pass P39086-2 2897 21q21.3 human S885-p 457627 KSRTKGKsSFTSILT receptor desensitization, altered; receptor internalization, altered 17898803 2 0 0 induced by phorbol ester +ZBTB7A FBI1 C2H2-type zinc finger protein; DNA-binding; Transcription factor O95365 51341 19p13.3 human K61-sm 3982504 ACSQYFKkLFTSGAV BTB molecular association, regulation transcription, inhibited SMRT(INDUCES); N-CoR1(INDUCES); BCOR(INDUCES) 17595526 1 0 0 +FUS hnRNP P2 DNA-binding; Nuclear receptor co-regulator; Oncoprotein; RNA splicing; RNA-binding; SUMO LIGASE P35637 2521 16p11.2 human R518-me 1873375600 MDSRGEHrQDRRERP intracellular localization KPNB2(DISRUPTS) 22968170 1 0 0 Arginines in the RGG3 domain are required for nuclear import of mutant hnRNP, and arginine methylation in this domain reduces KPNB2 binding. +H3-3A H3 DNA-binding Q71LE2 396970 pig K27-m1 465522 LATKAARkSAPSTGG Histone transcription, inhibited 19536841 22 20 47 low levels of trimethylated H3K27 detected +Prkd1 PRKD1 Autophagy; EC 2.7.11.13; KINASE; Kinase, protein; Motility/polarity/chemotaxis; Protein kinase, CAMK; Protein kinase, Ser/Thr (non-receptor) Q62101 18760 12|12 B3 mouse S407-p 3196826 RTISPSTsNNIPLMR enzymatic activity, inhibited 19135240 1 20 2 in vitro +ZWINT ZWINT Cell cycle regulation O95229 11130 10q21.1 human T251-p 20765002 TRPQEQStGDTMGRD Zwint molecular association, regulation; intracellular localization; phosphorylation cell cycle regulation ZW10(INDUCES) 21775627 1 1 0 inhibits phosphorylation of dynein and induces its recruitment with ZW10 to kinetochores, +HTR2A 5-HT(2A) GPCR, family 1; Membrane protein, integral; Membrane protein, multi-pass; Receptor, GPCR P28223 3356 13q14.2 human S280-p 6057802 GTRAKLAsFSFLPQS 7tm_1 receptor desensitization, induced 24637012 2 1 0 +L1CAM NCAM-L1 Cell adhesion; Membrane protein, integral P32004 3897 Xq28 human S1204-p 472276 GDIKPLGsDDSLADY Bravo_FIGEY cytoskeletal reorganization 17151951 2 0 0 +Mybl2 B-Myb DNA-binding; Motility/polarity/chemotaxis; Transcription factor P48972 17865 2 H2|2 84.0 cM mouse S581-p 450115 RKPGLRRsPIKKVRK Cmyb_C activity, induced transcription, induced 10593981; 9840932 5 0 0 +SLC5A6 SLC5A6 Membrane protein, integral; Membrane protein, multi-pass; Transporter; Transporter, SLC family Q9Y289 8884 2p23.3 human T78-p 62925703 VALSLLAtFQSAVAI SSF; TM intracellular localization 28052864 1 0 0 membrane localization, biotin uptake +DTD1 DTD1 DNA replication; EC 3.1.-.-; Hydrolase Q8TEA8 92675 20p11.23 human S196-p 476434 RKEDRSAsSGAEGDV molecular association, regulation cell cycle regulation; cell growth, induced MCM7(INDUCES); MCM3(DISRUPTS) 25258324 1 27 1 decreases DTD1 incorporation into HMW, supports DNA replication initiation +APC2 APCL Membrane protein, peripheral O95996 10297 19p13.3 human S1167-p 33370501 SRCSSVSsLGSFESP APC_r protein degradation; molecular association, regulation transcription, inhibited axin 1(INDUCES) 24722208 1 0 0 +LARP6 LARP6 Q9BRS8 55323 15q23 human S409-p 10942100 GRLNCSTsPEIFRKC molecular association, regulation; intracellular localization translation, induced STRAP(INDUCES) 28112218 2 11 0 regulates collagen production, contributes to LARP6 nuclear distribution, asssociation of LARP6 with ER membrane. +TRIM32 TRIM32 EC 6.3.2.-; EC 6.3.2.19; Ligase; UBIQUITIN LIGASE; Ubiquitin conjugating system; Ubiquitin ligase Q13049 22954 9q33.1 human K401-ub 573767732 RIQVFTRkGFLKEIR protein degradation; intracellular localization autophagy, induced 33999923 1 1 0 +PRKAA1 AMPKA1 Autophagy; EC 2.7.11.1; EC 2.7.11.26; EC 2.7.11.27; EC 2.7.11.31; KINASE; Kinase, protein; Protein kinase, CAMK; Protein kinase, Ser/Thr (non-receptor) Q13131 5562 5p13.1 human K118-sm 1877447402 ELFDYICkNGRLDEK Pkinase protein stabilization 34971706 1 0 0 +Foxa2 FOXA2 DNA-binding; Transcription factor P32182 rat S283-p 8046508 TAPGTQAsQVQLGEA transcription, altered 19478084 1 0 0 +HNRNPK hnRNP K RNA splicing; RNA-binding; Spliceosome P61978 3190 9q21.32 human Y236-p 456003 FYDETYDyGGFTMMF translation, altered 12052863 1 1 0 based on Y72/225/230/234/236/380A mutant +PRC1 PRC1 Cell cycle regulation; Cytoskeletal; Microtubule-binding; Motility/polarity/chemotaxis O43663 9055 15q26.1 human S615-p 4274308 ATSGILNsTNIQS__ molecular association, regulation PLK1(INDUCES) 17351640 2 1 0 phosphorylation and docking site of PLK1 +ATG13 ATG13 Autophagy; Vesicle O75143 9776 11p11.2 human T332-p 27444371 QERLATCtPSDRTHC cell cycle regulation; autophagy, induced; cell growth, induced 32516310 1 2 0 +USP15 USP15 DEUBIQUITINASE; EC 3.4.19.12; Protease; Ubiquitin conjugating system; Ubiquitin-specific protease Q9Y4E8 9958 12q14.1 human S229-p 467037 RGPSTPKsPGASNFS cell cycle regulation 29429988 1 65 31 did not reduce the number of CENP-A-positive micronuclei; promotes genome instability +CCR2 CCR2 GPCR, family 1; Membrane protein, integral; Membrane protein, multi-pass; Receptor, GPCR P41597 729230 3p21.31 human Y139-p 448635 ILLTIDRyLAIVHAV 7tm_1 molecular association, regulation JAK2(INDUCES); STAT3(INDUCES); G-alpha i2(INDUCES) 9670957 1 0 0 +Ager RAGE Cell cycle regulation; Membrane protein, integral; Motility/polarity/chemotaxis; Receptor, misc. Q62151 11596 17|17 B1 mouse S389-p 4731275 ERAELNQsEEAEMPE DNA repair, induced 28977635 4 2 0 +BAX BAX Apoptosis; Membrane protein, integral; Mitochondrial; Tumor suppressor Q07812 581 19q13.33 human T172-p 28847908 FGTPTWQtVTIFVAG TM intracellular localization apoptosis, induced 23907458 1 0 0 +TWIST1 TWIST1 Cell development/differentiation; DNA-binding; Inhibitor; Transcription regulation Q15672 7291 7p21.1 human S20-p 18899300 ADDSLSNsEEEPDRQ protein stabilization carcinogenesis, altered; cell motility, altered 21559372 1 0 0 +Dnm1 DYN1 EC 3.6.5.5; Hydrolase; Microtubule-binding; Motility/polarity/chemotaxis; Motor; Vesicle P21575 140694 3p12 rat S774-p 450205 SVPAGRRsPTSSPTP molecular association, regulation endocytosis, altered endophilin A1(INDUCES); PACSIN1(INDUCES); PACSIN1(DISRUPTS) 16648848; 17437541; 20526333 14 34 21 regulates synaptic vesicle endocytosis; required for activity-dependent bulk endocytosis (ADBE), but not clathrin-mediated endocytosis (CME) ; interaction essential for synaptic vesicle endocytosis +BCL9 Bcl-9 Oncoprotein; Transcription factor O00512 607 1q21.2 human T172-p 3150953 EPTPAQKtPAKVVYV protein stabilization; molecular association, regulation CLTC(DISRUPTS); Myc(INDUCES); CTNNB1(INDUCES) 30217955 1 5 10 stabilizing signalosome and Wnt signaling, promotes oncogenic activity of Bcl-9, regulates cell division +Ankrd54 ANKRD54 Cell cycle regulation Q91WK7 223690 15 E1|15 37.7 cM mouse S18-p 239773903 ESRSGRSsSDGECAV molecular association, regulation; intracellular localization LYN(INDUCES) 28924458 1 1 0 nuclear export, cytoplasmic accumulation +Pea15 PEA-15 Apoptosis; Motility/polarity/chemotaxis Q9Z297 100736554 hamster S116-p 450281 KDIIRQPsEEEIIKL molecular association, regulation FADD(INDUCES) 15916534 15 95 1092 +PTK2 FAK EC 2.7.10.2; KINASE; Kinase, protein; Protein kinase, TK; Protein kinase, tyrosine (non-receptor) Q05397 5747 8q24.3 human S843-p 447963 DVRLSRGsIDREDGS cytoskeletal reorganization 17096371 7 14 7 represses phosphorylation of Y397 in integrin-stimulated cells +EP300 p300 ACETYLTRANSFERASE; Acetyltransferase; EC 2.3.1.48; Motility/polarity/chemotaxis; Nuclear receptor co-regulator; Transcription, coactivator/corepressor Q09472 2033 22q13.2 human K1024-sm 12063901 TELKTEIkEEEDQPS molecular association, regulation transcription, inhibited HDAC6(INDUCES) 12718889 1 1 0 +APC APC Motility/polarity/chemotaxis; Tumor suppressor P25054 324 5q22.2 human S2789-p 2897402 TPFNYNPsPRKSSAD EB1_binding molecular association, regulation EB1(DISRUPTS) 15616574; 19632184 2 14 1 +PDE11A PDE11A EC 3.1.4.17; EC 3.1.4.35; Mitochondrial; Nucleotide Metabolism - purine; Phosphodiesterase Q9HCR9 50940 2q31.2 human S117-p 2243101 GNLQRRAsQKELRKS enzymatic activity, induced 18312413 2 0 0 +ENDOG ENDOG Apoptosis; Deoxyribonuclease; EC 3.1.30.-; Mitochondrial; Ribonuclease Q14249 2021 9q34.11 human S288-p 1871762500 NILARAGsLKAITAG protein degradation; molecular association, regulation autophagy, induced; signaling pathway regulation 14-3-3 gamma(INDUCES) 33473107 1 0 0 binding to 14-3-3 gamma inhibits 14-3-3 gamma binding to TSC2 and Vps34, inhibits mTOR signaling pathway, induces SQSTM1 degradation +Ezr Ezrin Cytoskeletal; Motility/polarity/chemotaxis P26040 22350 17|17 A1 mouse T567-p 448104 QGRDKYKtLRQIRQG ERM_C activity, induced; molecular association, regulation; intracellular localization; phosphorylation cell growth, inhibited; apoptosis, inhibited; cell motility, altered; autophagy, inhibited; cell motility, inhibited; cytoskeletal reorganization; cell adhesion, inhibited Ezrin(INDUCES); MCF2(INDUCES) 12769842; 15196952; 15504914; 15781656; 19890007; 22147261; 24250818; 32154600; 35625669; 9456324 68 9 16 +SRC Src EC 2.7.10.2; KINASE; Kinase, protein; Oncoprotein; Protein kinase, TK; Protein kinase, tyrosine (non-receptor) P00523 396442 chicken S48-p 2420700 PDTHRTPsRSFGTVA phosphorylation cell growth, altered 2474754 3 3 0 Mutation of S16 increases phosphorylation at S12 +STK33 STK33 EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, CAMK; Protein kinase, Ser/Thr (non-receptor) Q9BYT3 65975 11p15.4 human T382-p 25755119 LLDNQWLtGNKLSSV protein degradation; molecular association, regulation; ubiquitination PELI1(INDUCES) 31537781 1 0 1 +SEC63 SEC63 Endoplasmic reticulum; Membrane protein, integral; Membrane protein, multi-pass Q9UGP8 11231 6q21 human S748-p 3215004 DSEGFEDsFEEEEEE molecular association, regulation SEC62(INDUCES) 23287549 1 5 0 +Gapdh GAPDH Carbohydrate Metabolism - glycolysis and gluconeogenesis; EC 1.2.1.12; Oxidoreductase P04797 24383 4q42 rat T227-gl 7533204 PELNGKLtGMAFRVP Gp_dh_C molecular association, regulation; intracellular localization; protein conformation GAPDH(DISRUPTS) 19022411 1 1 0 +Csnk2a1 CK2A1 EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, Other; Protein kinase, Ser/Thr (non-receptor) P19139 116549 3q41 rat Y255-p 450324 VLGTEDLyDYIDKYN Pkinase autophagy, induced 37237886 5 2 14 +DYRK2 DYRK2 iso2 EC 2.7.12.1; KINASE; Kinase, protein; Protein kinase, CMGC; Protein kinase, dual-specificity (non-receptor) Q92630-2 8445 12q15 human T484-p 1874397812 VKRITEStGAITSIS intracellular localization cell cycle regulation; apoptosis, induced 34363019 1 1 0 +PTTG1 Securin Cell cycle regulation; Oncoprotein O95997 9232 5q33.3 human S87-p 3845109 PLKQKQPsFSAKKMT Securin protein degradation; ubiquitination; enzymatic activity, induced chromatin organization, altered 24781523 1 5 0 1) Phosphorylation of securing leads to premature activation of separase. 2) Prevention of securin phosphorylation leads to impaired chromosome segregation and thereby leads to DNA damage. +KLF11 TIEG2 C2H2-type zinc finger protein; DNA-binding; Transcription factor O14901 8462 2p25.1 human T73-p 456008 LLRIRPLtPVSDSGD molecular association, regulation SIN3A(DISRUPTS) 12006497 1 0 1 +NUP98 NUP98 iso2 Motility/polarity/chemotaxis; Nucleoporin P52948-2 4928 11p15.4 human S499-p 18330801 TYSPFGDsPLFRNPM intracellular localization 21335236 1 1 1 as multiple sites (13PM) mutant +Irf8 IRF8 DNA-binding; Transcription factor P23611 15900 8 E1|8 70.05 cM mouse Y211-p 486243 QMVISFYyGGKLVGQ IRF-3 molecular association, regulation transcription, induced PU.1(INDUCES); STAT1(INDUCES) 17386941 1 0 0 as a part of IRF8-PU.1-STAT1 complex binding to LILRE (LPS and IL1 responsive element) regulates IL1B gene expression; Y211F mutant is a dominant-negative inhibitor of LPS-induced IL1B reporter gene +TFCP2 TFCP2 DNA-binding; Transcription factor Q12800 7024 12q13.12-q13.13 human S309-p 7965105 SLGEGNGsPNHQPEP activity, inhibited cell cycle regulation; transcription, inhibited 19237534; 20682773 2 0 0 +Tnnt2 TNNT2 iso2 Motility/polarity/chemotaxis; Motor P50753-2 24837 13q13 rat T285-p 451557 TRGKAKVtGRWK___ Troponin protein conformation 24708997 6 0 0 T204E mutant blunts Ca2+ sensitivity, PKC phosphorylation of these residues can increase or decrease Ca2+ sensitivity and cardiac regulation +SRF SRF Motility/polarity/chemotaxis; Transcription factor P11831 6722 6p21.1 human K165-me 1881502502 YTTFSKRkTGIMKKA cell differentiation, induced; transcription, induced DNA(INDUCES) 33564100 1 0 0 +Ifngr1 IFNGR1 Membrane protein, integral; Receptor, cytokine P15261 15979 10 A3|10 8.49 cM mouse Y467-p 454436 GKESLMGyRLTGEAQ molecular association, regulation SOCS1(INDUCES) 15522878 1 0 1 +Camk2a CAMK2A EC 2.7.11.17; KINASE; Kinase, protein; Protein kinase, CAMK; Protein kinase, Ser/Thr (non-receptor) P11798 12322 18 E1|18 34.41 cM mouse T253-p 451571 DLINKMLtINPSKRI Pkinase enzymatic activity, induced 28065796 8 5 1 ischemia/excitotoxicity induced cell death +FGD1 FGD1 GEF; GEF, misc. P98174 2245 Xp11.22 human S207-p 1876820500 PRAEASPsSAAVSSL cytoskeletal reorganization 35290799 0 1 0 +Slc1a1 SLC1A1 Membrane protein, integral; Membrane protein, multi-pass; Transporter; Transporter, SLC family P51907 25550 1q52 rat T5-p 13204400 ___MGKPtSSGCDWR activity, inhibited 19922365 1 0 0 +RAC2 RAC2 G protein; G protein, monomeric; G protein, monomeric, Rho; Motility/polarity/chemotaxis P15153 5880 22q13.1 human K123-ub 12402500 KLDLRDDkDTIEKLK Ras protein degradation; molecular association, regulation; ubiquitination ALDH2(INDUCES) 35354308 1 7 2 rs671 mutation had significantly lower efferocytotic ability compared with wild-type, ALDH2 WT interacted with RAC2 and stabilized it by inhibited K48-linked polyubiquitination at K123. +Gja1 GJA1 Channel, misc.; Membrane protein, integral; Membrane protein, multi-pass; Motility/polarity/chemotaxis P08050 24392 20q11 rat S306-p 465459 RNYNKQAsEQNWANY Connexin43 activity, induced 19879542 2 20 3 mutation of this site decreases single channel conductance and gating +MAGEA11 MAGE-A11 Cancer Testis Antigen (CTA); Transcription, coactivator/corepressor P43364 4110 Xq28 human T360-p 2028410 GEPKRLLtQNWVQEK MAGE transcription, induced 23853093 3 0 0 induce activation of E2F1 +Plin1 perilipin 1 Lipid-binding Q8CGN5 103968 7|7 D2 mouse S511-p 4759532 ILGRAQYsQLRKKS_ cell differentiation, inhibited; transcription, inhibited 36233344 1 5 0 +Arpp19 ARPP-19 Cell cycle regulation; Phosphatase, regulatory subunit Q712U5 60336 8q24 rat S62-p 465742 KGQKYFDsGDYNMAK Endosulfine enzymatic activity, inhibited 28167675 3 70 47 inhibits PP2A activity +SIAH1 SIAH1 Apoptosis; Cell development/differentiation; EC 6.3.2.-; EC 6.3.2.19; Ligase; Motility/polarity/chemotaxis; UBIQUITIN LIGASE; Ubiquitin conjugating system; Ubiquitin ligase Q8IUQ4 6477 16q12.1 human T70-p 36694104 SNCRPKLtCCPTCRG molecular association, regulation; acetylation; intracellular localization signaling pathway regulation GAPDH(INDUCES) 25391652 1 0 0 augments p300 acetylation; nuclear translocation +SP1 SP1 C2H2-type zinc finger protein; DNA-binding; Transcription factor P08047 6667 12q13.13 human S720-p 36897202 GGPGVALsVGTLPLD protein stabilization; molecular association, regulation; intracellular localization cell cycle regulation RNF4(DISRUPTS) DNA(DISRUPTS) 25398907 1 0 0 +PTEN PTEN Carbohydrate Metabolism - inositol phosphate; EC 3.1.3.16; EC 3.1.3.48; EC 3.1.3.67; Motility/polarity/chemotaxis; Nuclear receptor co-regulator; PHOSPHATASE; Phosphatase, lipid; Tumor suppressor P60484 5728 10q23.31 human T401-p 4695763 EDQHTQItKV_____ molecular association, regulation MAST2(DISRUPTS); DLG1(DISRUPTS) 10646847 1 0 0 +Yap1 YAP1 Oncoprotein; Transcription, coactivator/corepressor Q2EJA0 363014 8q11 rat S112-p 448847 PQHVRAHsSPASLQL protein degradation; intracellular localization; activity, inhibited apoptosis, induced; transcription, inhibited 27369082; 33568044; 35320001 207 33 180 +ADAR ADAR EC 3.5.4.37; Hydrolase; Nucleolus; RNA processing; RNA-binding P55265 103 1q21.3 human S825-p 3193222 TMLLLSRsPEAQPKT phosphorylation carcinogenesis, inhibited; apoptosis, induced 32812257 1 31 2 induces phosphorylation of eIF2 +Rph3a rabphilin 3A Vesicle P47708 19894 5|5 F mouse S271-p 455801 AGLRRANsVQAARPA intracellular localization cytoskeletal reorganization 11466418; 28636945 3 5 0 polarization +KIF11 KIF11 Microtubule-binding; Motor P52732 3832 10q23.33 human S1033-p 20798600 GINTLERsKVEETTE Microtub_bind molecular association, regulation; intracellular localization cell cycle regulation TPX2(INDUCES); ERCC2(DISRUPTS) 21642957; 29276125; 35977011 4 9 0 +CHUK IKKA EC 2.7.11.10; KINASE; Kinase, protein; Protein kinase, Other; Protein kinase, Ser/Thr (non-receptor) O15111 1147 10q24.31 human K296-ub 12109229 GPVDLTLkQPRCFVL Pkinase protein stabilization; intracellular localization; enzymatic activity, induced transcription, induced 35918322 1 3 1 transcription of adhesion molecules promote the adhesion of tumor cells to the endothelium, leading to extravasation, colonization and metastasis +DNMT1 DNMT1 Amino Acid Metabolism - cysteine and methionine; Cell development/differentiation; EC 2.1.1.37; METHYLTRANSFERASE; Methyltransferase; Methyltransferase, DNA; Transcription regulation P26358 1786 19p13.2 human S714-p 452655 DNIPEMPsPKKMHQG molecular association, regulation; intracellular localization; protein conformation; enzymatic activity, induced carcinogenesis, induced; cell growth, induced; chromatin organization, altered; transcription, inhibited DNA(INDUCES) 32071079; 35402240 4 69 10 +SDCBP syntenin Adaptor/scaffold; Cell adhesion; Cytokine; Membrane protein, integral; Motility/polarity/chemotaxis; Vesicle O00560 6386 8q12.1 human S131-p 56649728 KIGLRLKsIDNGIFV Peptidase_M50; PDZ protein stabilization; molecular association, regulation carcinogenesis, induced; signaling pathway regulation Src(INDUCES); EGFR(INDUCES); FAK(INDUCES) 32572158 1 1 0 AURKA-SDCBP-EGFR-PI3K-AKT pathway; Inhibits ubiquitination +SAV1 SAV1 Adaptor/scaffold Q9H4B6 60485 14q22.1 human S269-p 21507301 YRHPCAPsVPRYDQP protein conformation apoptosis, induced 21944251 1 1 0 self-dimerization; increase in protein level +MOB1A MOB1A Protein kinase, regulatory subunit Q9H8S9 55233 2p13.1 human Y26-p 465048 IPEGSHQyELLKHAE molecular association, regulation; intracellular localization STEP(INDUCES) 28675297 2 3 169 dephosphorylation at this site by PTPN5 is critical for its midbody localization +Slc43a2 SLC43A2 Membrane protein, integral; Membrane protein, multi-pass; Transporter; Transporter, SLC family Q8CGA3 215113 11|11 B5 mouse S274-p 2508983 TTVGRRLsVGSSMRT MFS_1 intracellular localization 32470053 2 28 1 +USP10 USP10 DEUBIQUITINASE; EC 3.4.19.12; Protease; RNA-binding; Ubiquitin conjugating system; Ubiquitin-specific protease Q14694 9100 16q24.1 human T42-p 12483201 SGTVLCGtQAVDKLP protein stabilization; ubiquitination; intracellular localization carcinogenesis, inhibited; cell growth, altered 20096447 1 0 0 regulates p53 homeostasis +VPS13D VPS13D Vesicle Q5THJ4 55187 1p36.22-p36.21 human Y768-p 25316392 TQFSDDEyKTPLATP VPS13_mid_rpt molecular association, regulation; intracellular localization VAPB(INDUCES) 33891013 1 0 1 +MAFA MAFA DNA-binding; Oncoprotein; Transcription factor; Tumor suppressor Q8NHW3 389692 8q24.3 human S49-p 1320400 CHRLPPGsLSSTPLS protein degradation; molecular association, regulation; ubiquitination carcinogenesis, induced; transcription, induced PCAF(INDUCES) 18042454 4 1 0 +GATA4 GATA4 Motility/polarity/chemotaxis; Transcription factor P43694 2626 8p23.1 human K327-ac 1877203100 RKPKNLNkSKTPAAP apoptosis, inhibited; transcription, induced 32239217 1 0 0 +TGFBR2 TGFBR2 EC 2.7.11.30; KINASE; Kinase, protein; Membrane protein, integral; Oncoprotein; Protein kinase, Ser/Thr (receptor); Protein kinase, TKL P37173 7048 3p24.1 human Y259-p 2869604 KGRFAEVyKAKLKQN PK_Tyr_Ser-Thr enzymatic activity, induced transcription, altered 9169454 2 0 0 +HJURP HJURP Histone-binding; Nucleolus Q8NCD3 55355 2q37.1 human S211-p 17555083 DPAKPASsPREWDPL molecular association, regulation cell cycle regulation 28017591 1 4 0 prevents premature CENP-A assembly +Stat6 STAT6 DNA-binding; Transcription factor P52633 20852 10 D3|10 74.59 cM mouse Y641-p 447757 MGKDGRGyVSTTIKM protein degradation; intracellular localization cell differentiation, induced; transcription, induced; transcription, altered; signaling pathway regulation 12244176; 33504618; 33736980; 34795444; 36057627 27 6 95 +ETS1 Ets-1 DNA-binding; Motility/polarity/chemotaxis; Oncoprotein; Transcription factor P14921 2113 11q24.3 human Y283-p 449428 SLQRVPSyDSFDSED Ets1_N_flank protein stabilization; molecular association, regulation carcinogenesis, induced; cell motility, induced; transcription, altered COP1(DISRUPTS); SP1(INDUCES) 25117710; 36305724 2 5 18 +DCLRE1C Artemis DNA repair, damage; Deoxyribonuclease; EC 3.1.-.- Q96SD1 64421 10p13 human S645-p 457531 NLSTNADsQSSSDFE molecular association, regulation; ubiquitination; intracellular localization cell cycle regulation; DNA repair, induced FBXW7(INDUCES); PAXIP1(INDUCES) 16600297; 17242184; 19423708; 25512557 6 2 0 facilitates recovery from the replication checkpoint in response to DNA damage; Artermis regulates Cdk1-cyclin B during IR-induced G2/M arrest and Cdk1-cyclin B nuclear import.; Artemis prevents end resection and promotes non-homologous end joining; interaction with FBXW7 stimulates ubiquitination and degradation of cyclin E +PHF5A PHF5A RNA splicing; RNA-binding Q7RTV0 84844 22q13.2 human Y36-p 463988 KCVICDSyVRPCTLV PHF5 cell cycle regulation; carcinogenesis, induced; cell motility, induced; cell growth, induced; cytoskeletal reorganization 36759599 1 2 4 +Def6 DEF6 GEF; GEF, Rac/Rho Q8C2K1 23853 17|17 A3.3 mouse Y133-p 6094305 NFLSEDKyPLIMVPD activity, induced; intracellular localization cell differentiation, altered; transcription, altered 18976935 1 0 0 +IFIH1 MDA5 Apoptosis; EC 3.6.4.13; Helicase Q9BYX4 64135 2q24.2 human K743-ub 62495529 QWITENEkFAEVGVK Helicase_C activity, induced; molecular association, regulation transcription, induced MDA5(INDUCES) 28031478 1 1 0 oligomerization, activation, induces antiviral innate immunity +Map2 MAP2 iso3 Cytoskeletal; Motility/polarity/chemotaxis P15146-3 25595 9q32 rat K352-ac 62495515 TSKCGSLkNIRHRPG Tubulin-binding cytoskeletal reorganization 28002468 1 1 0 +ABL1 Abl iso2 EC 2.7.10.2; KINASE; Kinase, protein; Oncoprotein; Protein kinase, TK; Protein kinase, tyrosine (non-receptor) P00519-2 25 9q34.12 human Y412-p 450298 RLMTGDTyTAHAGAK PK_Tyr_Ser-Thr enzymatic activity, induced apoptosis, induced; transcription, altered 11781820; 22975324 24 49 1642 +LIFR LIFR Membrane protein, integral; Receptor, cytokine P42702 3977 5p13.1 human S1044-p 450385 WNLVSPDsPRSIDSN activity, induced; protein degradation; molecular association, regulation; intracellular localization; activity, inhibited; phosphorylation carcinogenesis, induced; cell motility, induced; cell growth, induced; cell adhesion, induced; signaling pathway regulation; transcription, inhibited LIFR(INDUCES) 10858440; 18624908; 22306348; 30851421; 35172032; 7777512 7 6 0 necessary for homodimerization and subsequent S1044 phosphorylation, and consequent AKT activation, and PCa progression, promoted the growth and metastasis of PCa cells; PI3K-AKT pathway +Erbb2 HER2 EC 2.7.10.1; KINASE; Kinase, protein; Membrane protein, integral; Oncoprotein; Protein kinase, TK; Protein kinase, tyrosine (receptor) P06494 24337 10q31 rat Y879-p 448694 LDIDETEyHADGGKV PK_Tyr_Ser-Thr molecular association, regulation; phosphorylation cell growth, altered EGFR(INDUCES) 15163624; 9671404 25 14 111 +RAPH1 RAPH1 Adaptor/scaffold; Motility/polarity/chemotaxis Q70E73 65059 2q33.2 human Y1226-p 458696 GGSHISGyATLRRGP molecular association, regulation cell motility, induced 26996666 2 8 122 Lpd-Scar/WAVE interaction is positively regulated by c-Abl and c-Src, breast cancer cell invasion +Map3k2 MEKK2 EC 2.7.11.25; KINASE; Kinase, protein; Protein kinase, STE; Protein kinase, Ser/Thr (non-receptor) F1M9D0 171492 18p12 rat S239-p 3216828 SRMPRAQsYPDNHQE apoptosis, induced 28039298 1 46 239 +Scnn1b ENaC-beta Channel, sodium; Membrane protein, integral; Membrane protein, multi-pass; Transporter, ion channel Q9WU38 20277 7 F2|7 65.07 cM mouse T613-p 451219 QTLPIPGtPPPNYDS activity, inhibited 17724164 6 1 0 T613A mutation causes a reduced inhibitory response of EGF on reduction of short circuit current. Most likely a change in open probability. +TLN1 talin 1 Cytoskeletal; Motility/polarity/chemotaxis Q9Y490 7094 9p13.3 human T144-p 3801749 KKEEITGtLRKDKTL cell motility, altered; cell adhesion, induced 27698901 1 7 18 +Myo3b MYO3B Actin-binding; EC 2.7.11.1; KINASE; Kinase, protein; Motor; Protein kinase, STE; Protein kinase, Ser/Thr (non-receptor) Q1EG27 329421 2|2 C2 mouse S171-p 36841905 GVSAQLTsTRLRRNT Pkinase enzymatic activity, induced 21895655 1 1 0 +Lsr LISCH iso2 Membrane protein, integral; Receptor, misc. Q99KG5-2 54135 7|7 B1 mouse S288-p 4771509 PGDFDRTsSVGGHSS intracellular localization 24889144 1 2 0 at tricellular tight junctions +MT-CO1 COX1 EC 1.9.3.1; Energy Metabolism - oxidative phosphorylation; Membrane protein, integral; Membrane protein, multi-pass; Mitochondrial; Oxidoreductase P00395 4512 - human K13-ac 1879877105 WLFSTNHkDIGTLYL apoptosis, induced 31647884 1 0 0 mutant sites were found to significantly suppressed the AAPH-evoked increase in both ROS level and apoptosis +RPA2 RFA2 DNA replication P15927 6118 1p35.3 human S4-p 470082 ____MWNsGFESYGS molecular association, regulation; intracellular localization cell cycle regulation; DNA repair, induced; carcinogenesis, inhibited; apoptosis, induced; transcription, altered; cell growth, altered p53(INDUCES) 17035231; 18003706; 18289945; 21731742; 29875999; 30573684; 32989256; 37409248 48 2 0 +KIF18A KIF18A Microtubule-binding; Motor Q8NI77 81930 11p14.1 human S674-p 3207069 TRRKLMPsPLKGQHT molecular association, regulation; enzymatic activity, inhibited cell cycle regulation PPP2R2C(DISRUPTS); PPP2R3B(INDUCES); PPP2R5C(DISRUPTS); PPP2R3A(INDUCES) 32900880 0 9 0 +KCNIP3 calsenilin Calcium-binding; Transcription factor Q9Y2W7 30818 2q11.1 human S95-p 471337 FTKKELQsLYRGFKN intracellular localization 17102134 1 0 0 inhibits trafficking of Kv4.2 potassium channels to the plasma membrane +SPP1 osteopontin Secreted; Secreted, signal peptide P10451 6696 4q22.1 human S129-p 455740 ESHHSDEsDELVTDF Osteopontin molecular association, regulation; activity, inhibited Other(INDUCES) 19775205 1 5 0 peptide with phosphorylated S117, S120, S123, S126 and S129 has increased binding to hydroxyapatite, and inhibits bone mineralization in vivo and in vitro +Nrip1 RIP140 Nuclear receptor co-regulator; Transcription, coactivator/corepressor Q8CBD1 268903 16|16 C3.1 mouse S102-p 3345202 AAKRKRLsDSIVNLN NRIP1_repr_1 molecular association, regulation; methylation; intracellular localization transcription, altered 14-3-3 beta(INDUCES); PRMT1(INDUCES) 18628823 1 2 0 regulates fat accumulation +MYH7 MYH7 Motility/polarity/chemotaxis; Motor P12883 4625 14q11.2 human K213-ac 1881951900 KKDQSPGkGTLEDQI protein conformation 35502901 0 1 0 +MAK MAK EC 2.7.11.22; KINASE; Kinase, protein; Nuclear receptor co-regulator; Protein kinase, CMGC; Protein kinase, Ser/Thr (non-receptor) P20794 4117 6p24.2 human T157-p 4715052 LRSQPPYtDYVSTRW Pkinase phosphorylation; enzymatic activity, induced cell cycle regulation 21986944 1 3 614 phosphorylates myelin basic proteins and CDH1 +PRMT7 PRMT7 EC 2.1.1.125; EC 2.1.1.126; METHYLTRANSFERASE; Methyltransferase; Methyltransferase, protein arginine; RNA processing Q9NVM4 54496 16q22.1 human R531-m1 63128900 FRDLWRIrSPCGDCE molecular association, regulation carcinogenesis, induced; cell motility, induced; transcription, inhibited YY1(INDUCES) 28188177 1 1 0 +SSTR5 SSTR5 Cell cycle regulation; GPCR, family 1; Membrane protein, integral; Membrane protein, multi-pass; Receptor, GPCR P35346 6755 16p13.3 human T333-p 27724400 GAKDADAtEPRPDRI receptor internalization, induced; receptor recycling, induced 23418396; 24637622 2 0 0 +PXN PXN Adaptor/scaffold; Cell adhesion; Cytoskeletal; Motility/polarity/chemotaxis P49023 5829 12q24.23 human S130-p 450228 KQKSAEPsPTVMSTS Paxillin cell motility, induced; cytoskeletal reorganization 23549785 5 25 4 HGF mediated disassembly of focal adhesions and cell migration +Cckar CCKAR GPCR, family 1; Membrane protein, integral; Membrane protein, multi-pass; Receptor, GPCR P30551 24889 14q11 rat S260-p 451123 QGIKFDAsQKKSAKE 7tm_1 receptor desensitization, altered 11078715 2 0 0 +Atp1a1 ATP1A1 EC 3.6.3.9; Hydrolase; Membrane protein, integral; Membrane protein, multi-pass; Transporter; Transporter, ion channel P06685 24211 2q34 rat Y10-p 452054 KGVGRDKyEPAAVSE activity, induced; enzymatic activity, inhibited 10473631; 28344437 2 9 208 +TKT TKT Carbohydrate Metabolism - pentose phosphate pathway; EC 2.2.1.1; Transferase P29401 7086 3p21.1 human T382-p 34711200 GCATRNRtVPFCSTF Transket_pyr activity, induced; enzymatic activity, induced 24981175; 31534226 2 0 2 Rugulation of Low Barrier Hydrogen Bonds (LBHB) +Pfn2 profilin 2 Actin-binding; Motility/polarity/chemotaxis Q9JJV2 18645 3 D|3 28.15 cM mouse S138-p 35541800 MAKYLRDsGF_____ Profilin neural plasticity; cytoskeletal reorganization 36875774 2 0 0 +CCP110 CP110 Cell cycle regulation O43303 9738 16p12.3 human T194-p 2024013 FPKTSSAtPQETLIS intracellular localization cell cycle regulation 12361598 2 2 0 +PTPN11 SHP-2 iso1 EC 3.1.3.48; Motility/polarity/chemotaxis; PHOSPHATASE; Protein phosphatase, tyrosine (non-receptor) Q06124-1 5781 12q24.13 human Y584-p 448493 REDSARVyENVGLMQ molecular association, regulation; enzymatic activity, induced GAB2(INDUCES) 23980151 18 60 1189 +Cd79a Ig-alpha Immunoglobulin superfamily; Membrane protein, integral P11911 12518 7 A3|7 13.49 cM mouse S197-p 21127303 CSMYEDIsRGLQGTY ITAM activity, inhibited; phosphorylation signaling pathway regulation 20940318; 21841126 3 0 0 negatively regulates B-cell antigen receptor signaling; modulates T cell independent type II Ag response; phosphorylation at this site inhibits in vivo phosphorylation of tyrosine in Ig alpha +Ikbkb IKKB EC 2.7.11.10; KINASE; Kinase, protein; Protein kinase, Other; Protein kinase, Ser/Thr (non-receptor) Q9QY78 84351 16q12.5 rat S181-p 447489 DQGSLCTsFVGTLQY Pkinase enzymatic activity, induced cell growth, altered 15935065 76 2 0 +Itk ITK EC 2.7.10.2; KINASE; Kinase, protein; Protein kinase, TK; Protein kinase, tyrosine (non-receptor) Q03526 16428 11 B1.1|11 27.75 cM mouse Y517-p 447997 RFVLDDQyTSSTGTK PK_Tyr_Ser-Thr phosphorylation; enzymatic activity, induced 12842872 3 8 260 stimulates phosphorylation of ITK Y186 +ELMO1 ELMO1 Cytoskeletal; Motility/polarity/chemotaxis Q92556 9844 7p14.2-p14.1 human Y724-p 455566 PSNYDFVyDCN____ cell motility, induced; cell adhesion, induced 26205662 2 5 175 +SHMT1 SHMT1 Amino Acid Metabolism - glycine, serine and threonine; Cofactor and Vitamin Metabolism - one carbon pool by folate; EC 2.1.2.1; Energy Metabolism - methane; Lyase; METHYLTRANSFERASE; Methyltransferase; Mitochondrial; Other Amino Acids Metabolism - cyanoamino acid P34896 6470 17p11.2 human K38-sm 12004406 VEVYNIIkKESNRQR SHMT intracellular localization 17446168 1 1 0 +AKAP5 AKAP5 Adaptor/scaffold P24588 9495 14q23.3 human T87-p 406855301 ASLKRLVtRRKRSES WSK molecular association, regulation ACTB(INDUCES) 29196604 1 0 0 AKAP5 de-palmitoylation, AKAP5 from dendritic spines +NUAK1 NuaK1 EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, CAMK; Protein kinase, Ser/Thr (non-receptor) O60285 9891 12q23.3 human S480-p 33406501 QRESGYYsSPERSES molecular association, regulation cell cycle regulation BRD8(INDUCES) 24785407 1 1 0 +Prkcq PKCT EC 2.7.11.13; KINASE; Kinase, protein; Protein kinase, AGC; Protein kinase, Ser/Thr (non-receptor) Q02111 18761 2 A1|2 8.42 cM mouse T219-p 457380 SAINSREtMFHKERF activity, induced 31694643 2 1 0 T cell activation +MAP3K5 ASK1 EC 2.7.11.25; KINASE; Kinase, protein; Protein kinase, STE; Protein kinase, Ser/Thr (non-receptor) Q99683 4217 6q23.3 human T1109-p 27928508 DRKIIATtLSKLKLE HisK-N-like enzymatic activity, inhibited carcinogenesis, induced 23608533 1 1 0 +Gabrb3 GABRB3 Channel, chloride; Channel, ligand-gated; Membrane protein, integral; Membrane protein, multi-pass; Transporter; Transporter, ion channel P63080 14402 7 B5|7 33.53 cM mouse S432-p 450245 KTHLRRRsSQLKIKI Neur_chan_memb molecular association, regulation cytoskeletal reorganization AP-2 alpha(DISRUPTS) 18184780; 26627235 12 0 0 increased dendritic spine density, alterations in GABRB3 expression, decreased social interaction and repetitive-like behavior in S408/9A mice +CUEDC2 CUEDC2 Q9H467 79004 10q24.32 human S110-p 18008416 VQGQVPIsPEPLQRP molecular association, regulation cell cycle regulation CDC20(INDUCES) 21743465 1 13 0 +Ppargc1a PGC-1 alpha Nuclear receptor co-regulator; Transcription, coactivator/corepressor O70343 19017 5|5 C1 mouse S194-p 13861601 SWSNKAKsICQQQKP intracellular localization transcription, induced 20351112 1 0 0 +CBX5 HP1 alpha Transcription, coactivator/corepressor P45973 23468 12q13.13 human S92-p 455944 SESNKRKsNFSNSAD cell cycle regulation; chromatin organization, altered 31130069 4 39 18 protect the cells against mitotic and chromosomal aberrations (regulates chromosomal stability) +VIM Vimentin Cytoskeletal; Motility/polarity/chemotaxis P08670 7431 10p13 human S83-p 451816 GVRLLQDsVDFSLAD Filament_head molecular association, regulation carcinogenesis, induced; cell motility, induced; cell growth, induced; cell motility, altered CDK1(INDUCES) 18056432; 27603133; 33963314 18 26 0 +PRPF3 PRPF3 RNA processing; RNA splicing; Spliceosome O43395 9129 1q21.2 human K289-sm 1872852108 KANIRAVkREQFKQQ molecular association, regulation RNA splicing, induced EFTUD2(INDUCES); SF3A1(INDUCES); PRP4(INDUCES) 28379520 1 0 0 +RREB1 RREB1 C2H2-type zinc finger protein; DNA-binding; Motility/polarity/chemotaxis; Nuclear receptor co-regulator; Transcription, coactivator/corepressor Q92766 6239 6p24.3 human K60-ac 1881352800 GRRNQETkEEKSSYN acetylation transcription, inhibited 34419497 1 1 0 wild-type pRREB1 and pRREB1 K60Q (mimetic mutant) had little influence on the binding of the encoded proteins RREB1 with the AKT1 promoter, while the K60R mutant AKT1 expression was increased. +Smarca2 SMARCA2 EC 3.6.1.-; EC 3.6.4.-; Helicase; Nuclear receptor co-regulator; Transcription, coactivator/corepressor Q6DIC0 67155 19 C1|19 21.17 cM mouse S1382-p 470425 RPPAEKLsPNPPKLT molecular association, regulation transcription, induced MTA3(DISRUPTS); TADA2B(DISRUPTS); HDAC2(DISRUPTS); SMC3(DISRUPTS); MTA1(DISRUPTS) 34260936 1 35 2 +BRAF BRAF EC 2.7.11.1; KINASE; Kinase, protein; Oncoprotein; Protein kinase, Ser/Thr (non-receptor); Protein kinase, TKL Q04982 396239 chicken S769-p 450242 PKIHRSAsEPSLNRA molecular association, regulation; enzymatic activity, induced 14-3-3 beta(INDUCES) 16702958 8 59 25 effect on kinase activity measured in vitro +PKP1 plakophilin 1 Cell adhesion; Motility/polarity/chemotaxis Q13835 5317 1q32.1 human S118-p 4712605 EPDNRRFsSYSQMEN intracellular localization 23444369 1 6 2 +Rfc1 RFC1 DNA replication D3ZFT1 89809 14p11 rat S71-p 452681 RIIYDSDsESEETVQ intracellular localization transcription, inhibited 10625661 1 65 4 +Twist1 TWIST1 Cell development/differentiation; DNA-binding; Inhibitor; Transcription regulation P26687 22160 12 A3|12 14.81 cM mouse S42-p 14821304 GARKRRSsRRSAGGS carcinogenesis, induced; transcription, induced 20400976; 27281171; 28915063; 32922123 5 1 0 +Cldn6 Claudin-6 Cell adhesion; Membrane protein, integral; Membrane protein, multi-pass Q9Z262 54419 17|17 A3.3 mouse Y196-p 7792482 GTQGPRHyMACYSTS cell adhesion, altered; signaling pathway regulation 31740618 1 0 17 +ERG ERG DNA-binding; Oncoprotein; Transcription factor P11308 2078 21q22.2 human S37-p 50259801 KTEMTASsSSDYGQT protein degradation; molecular association, regulation; ubiquitination cell motility, inhibited SPOP(INDUCES) 26344095; 26344096 2 1 0 +PXN PXN iso2 Adaptor/scaffold; Cell adhesion; Cytoskeletal; Motility/polarity/chemotaxis P49023-2 5829 12q24.23 human Y118-p 448604 VGEEEHVySFPNKQK Paxillin activity, induced; protein degradation; molecular association, regulation; intracellular localization; phosphorylation cell cycle regulation; apoptosis, altered; cell motility, induced; cell motility, altered; cytoskeletal reorganization; transcription, altered Src(INDUCES); CRKL(INDUCES) 15870699; 16491114; 17046825; 17574549; 18045996; 18794113; 20628053; 21898535; 7493940 83 79 2519 induces phosphorylation of IKB; essential for EGFR-mediated Erk1/2 activation and cell proliferation +NELFE RDBP Mitochondrial; Transcription, coactivator/corepressor P18615 7936 6p21.33 human S115-p 452641 QPFQRSIsADDDLQE molecular association, regulation transcription, induced 14-3-3 epsilon(INDUCES) 29523821 1 82 18 dissociation of the NELF complex from chromatin, which is accompanied by RNA polymerase II elongation +EIF5A2 EIF5A2 Q9GZV4 56648 3q26.2 human K47-ub 964512658 IVEMSTSkTGKHGHA protein degradation 35064108 1 2 0 regulate EMT, and may inhibit the metastasis of CRC +IRF1 IRF1 Transcription factor; Tumor suppressor P10914 3659 5q31.1 human S221-p 31839601 VSPMPSTsEATTDED molecular association, regulation; activity, inhibited transcription, inhibited NFkB-p65(DISRUPTS) 24396068 1 0 0 Phosphorylation impairs iNFkB-p65 interaction and PCAF mediated acetylation K310 -suppression of IFN-beta production +BRCA2 BRCA2 DNA repair, damage; Nuclear receptor co-regulator; Tumor suppressor P51587 675 13q13.1 human S193-p 469574 AEVDPDMsWSSSLAT molecular association, regulation; intracellular localization; enzymatic activity, induced cytoskeletal reorganization MYH14(INDUCES) 24448238 2 2 0 Inhibiting this binding inactivated the ATPase activity, formation of the midbody, and interruption of cytokinesis.; localizes to Flemming body +SLC12A1 NKCC2 Membrane protein, integral; Membrane protein, multi-pass; Transporter; Transporter, SLC family Q13621 6557 15q21.1 human S91-p 4708924 ASFHAYDsHTNTYYL AA_permease_N signaling pathway regulation 21321328 1 2 0 WNK-SPAK-OSR1 pathway +NDC80 HEC1 Cell cycle regulation O14777 10403 18p11.32 human T31-p 23112540 VNKQGLYtPQTKEKP cell cycle regulation; cytoskeletal reorganization 35878017; 36897279 2 7 1 +HDAC3 HDAC3 Apoptosis; Cell cycle regulation; DEACETYLASE; Deacetylase; EC 3.5.1.98; Nuclear receptor co-regulator; Transcription, coactivator/corepressor O15379 8841 5q31.3 human Y325-p 1267669100 AISEELPySEYFEYF activity, induced cell growth, induced 30317579 1 0 0 cell proliferation increased in HER2-positive breast cancer cells +PKP3 plakophilin 3 Cell adhesion Q9Y446 11187 11p15.5 human Y195-p 451533 PGGLDDRySLVSEQL intracellular localization 25501895 1 15 160 desmosome disassembly and function +Sox9 SOX9 DNA-binding; Transcription factor Q04887 20682 11 E2|11 77.27 cM mouse R177-me 10338209 PDYKYQPrRRKSVKN molecular association, regulation cell cycle regulation; cell growth, induced; transcription, induced CTNNB1(DISRUPTS) 19725955 1 0 0 promotes cyclin D1 expression, regulates endochondral ossification, chondrocyte/cartilage development during embryogenesis +Ppp3cb PPP3CB EC 3.1.3.16; PHOSPHATASE; Protein phosphatase, Ser/Thr (non-receptor) P48453 19056 14|14 A3 mouse K327-ub 1878212800 YLDVYNNkAAVLKYE cell cycle regulation; cell growth, inhibited; transcription, inhibited 31135381 1 1 0 USP16 regulates T cell proliferation and cell-cycle entry; Ubiquitination of PPP3CB impairs NFAT recruitment and transcription of NFAT-targeted genes +CAMK2D CAMK2D EC 2.7.11.17; KINASE; Kinase, protein; Protein kinase, CAMK; Protein kinase, Ser/Thr (non-receptor) Q13557 817 4q26 human T306-p 2023845 KLKGAILtTMLATRN enzymatic activity, inhibited 34391760 2 4 1 +XKR5 XKR5 Membrane protein, integral; Membrane protein, multi-pass Q6UX68 389610 8p23.1 human Y369-p 1172732401 GSCQGASyEPTILGK phosphorylation carcinogenesis, inhibited; cell growth, inhibited; signaling pathway regulation 29910466 1 1 0 inhibits phosphorylation of ERK, AKT and p38 +ERN1 IRE1 Apoptosis; Chaperone; EC 2.7.11.1; Endoplasmic reticulum; KINASE; Kinase, protein; Membrane protein, integral; Protein kinase, Other; Protein kinase, Ser/Thr (non-receptor); Ribonuclease O75460 2081 17q23.3 human S724-p 7161100 KLAVGRHsFSRRSGV Pkinase enzymatic activity, induced endocytosis, induced; autophagy, induced; RNA splicing, induced; apoptosis, induced; transcription, altered 16950141; 30045994; 36170818; 36739529 18 2 0 +CGAS cGAS EC 2.7.7.86 Q8N884 115004 6q13 human K394-ac 14366393 LNNHGKSkTCCENKE enzymatic activity, inhibited; protein conformation; activity, inhibited 30799039; 33438687 2 2 0 +RAF1 RAF1 EC 2.7.11.1; KINASE; Kinase, protein; Oncoprotein; Protein kinase, Ser/Thr (non-receptor); Protein kinase, TKL P04049 5894 3p25.2 human S259-p 447741 SQRQRSTsTPNVHMV protein stabilization; molecular association, regulation; intracellular localization; enzymatic activity, inhibited; phosphorylation cell differentiation, inhibited; cell cycle regulation; carcinogenesis, induced; apoptosis, altered; carcinogenesis, inhibited; cell motility, induced; transcription, induced; signaling pathway regulation; cell growth, induced; apoptosis, inhibited; cell growth, altered 14-3-3 beta(INDUCES); 14-3-3 theta(INDUCES); 14-3-3 zeta(INDUCES); MST2(INDUCES); HRas(DISRUPTS); PPP2CB(DISRUPTS) 10801873; 11756411; 11971957; 12609989; 12801936; 12865432; 16093354; 20212043; 20234004; 20679480; 20868520; 24929361; 34473994; 35564180; 35697074; 35810308; 35884549; 36564468; 8321321; 8637718 58 32 142 +Pten PTEN Carbohydrate Metabolism - inositol phosphate; EC 3.1.3.16; EC 3.1.3.48; EC 3.1.3.67; Motility/polarity/chemotaxis; Nuclear receptor co-regulator; PHOSPHATASE; Phosphatase, lipid; Tumor suppressor O08586 19211 19 C1|19 28.14 cM mouse S398-p 4695758 PFDEDQHsQITKV__ molecular association, regulation; intracellular localization; methylation; phosphorylation cell cycle regulation; carcinogenesis, induced; DNA repair, induced; carcinogenesis, inhibited; apoptosis, induced; apoptosis, inhibited; signaling pathway regulation MDC1(INDUCES); WHSC1(INDUCES) 31217297; 34059798 3 0 0 inhibits H2AX and CDK2 phosphorylation, inhibits AKT/p27Kip1 signaling; induces NSD2 mediated dimethylation of PTEN +H2AC11 H2A.1 DNA-binding P0C0S8 8329 6p22.1 human S1-p 451190 _______sGRGKQGG Histone activity, inhibited transcription, inhibited 15010469 3 3 0 +Ncf4 p40phox Oxidoreductase P97369 17972 15 E1|15 37.1 cM mouse T154-p 448266 LRRLRPRtRKIKGVS intracellular localization 20861461 5 0 0 translocation to S aureus phagosomes; essential for NADPH oxidase activity +SMURF2 SMURF2 EC 6.3.2.-; EC 6.3.2.19; Ligase; UBIQUITIN LIGASE; Ubiquitin conjugating system; Ubiquitin ligase Q9HAU4 64750 17q23.3-q24.1 human K734-ub 50760802 SYEKLYEkLLTAIEE HECT enzymatic activity, induced cell motility, induced; signaling pathway regulation 26435193 1 0 0 regulates TGF-beta signaling pathway (TGF-beta activity and biological effects), induces SMURF2 transthiolation +HTT Huntingtin Cytoskeletal P42858 3064 4p16.3 human K442-ac 7434500 LSRKQKGkVLLGEEE protein degradation; intracellular localization autophagy, induced 19345187 3 2 0 +NFKBIA IkB-alpha DNA-binding; Inhibitor P25963 4792 14q13.2 human K21-sm 2535907 EGPRDGLkKERLLDD activity, induced; protein stabilization; ubiquitination transcription, induced; transcription, inhibited 17956732; 20696840; 32770227; 9734360 6 0 0 inhibits ubiquitination +SREBF1 SREBP-1 DNA-binding; Membrane protein, integral; Membrane protein, multi-pass; Transcription factor P36956 6720 17p11.2 human S439-p 469115 AGSPFQSsPLSLGSR protein stabilization cell cycle regulation; transcription, induced 16880739 1 0 0 specific for mitotic cells regulates G1/S cell cycle +KAT5 Tip60 ACETYLTRANSFERASE; Acetyltransferase; EC 2.3.1.48; Nuclear receptor co-regulator; Nucleolus Q92993 10524 11q13.1 human K120-ac 52498000 TLRFNLPkEREAIPG protein degradation; intracellular localization apoptosis, altered 25301942 1 0 0 HDAC3 increased the TIP60 half-life, and the ubiquitination level of TIP60, nuclear localization, cytoplasm and nucleus with HDAC3 expressed, TIP60 deacetylation increases its resistance to apoptosis +Dzip1 DZIP1 C2H2-type zinc finger protein Q8BMD2 66573 14|14 E4 mouse S520-p 40586900 KPSSTSPsPQELRTN molecular association, regulation GDI2(INDUCES) 25860027 1 1 0 ciliogenesis +SRF SRF Motility/polarity/chemotaxis; Transcription factor P11831 6722 6p21.1 human S83-p 451800 YSGSEGDsESGEEEE molecular association, regulation DNA(INDUCES) 1547771 3 6 0 +CABLES1 CABLES1 Adaptor/scaffold Q8TDN4 91768 18q11.2 human T309-p 4270180 APLRRCRtLSGSPRP molecular association, regulation; phosphorylation; enzymatic activity, induced carcinogenesis, induced; apoptosis, inhibited; transcription, altered 14-3-3 gamma(INDUCES); CDK2(DISRUPTS) 25361894 1 2 10 inhibits phosphorylation of Cdk2 and increases its kinase activity, decreaes p21 and increases phosphorylated Rb protein levels +PPP2CA PPP2CA EC 3.1.3.16; Motility/polarity/chemotaxis; PHOSPHATASE; Protein phosphatase, Ser/Thr (non-receptor) P67775 5515 5q31.1 human Y307-p 448571 VTRRTPDyFL_____ molecular association, regulation; methylation; intracellular localization; enzymatic activity, inhibited; activity, inhibited; phosphorylation; enzymatic activity, induced cell cycle regulation; carcinogenesis, induced; apoptosis, altered; transcription, induced; signaling pathway regulation; cell growth, induced; autophagy, inhibited; cytoskeletal reorganization; translation, induced; cell growth, altered; translation, inhibited LCMT1(INDUCES); JAK2(DISRUPTS); PPP2R3A(DISRUPTS); PPP2R5D(NOT_REPORTED); PPP2R2A(DISRUPTS); PPP2R5A(NOT_REPORTED); ASH2L(INDUCES) 10978272; 12921784; 17303700; 17394530; 19366811; 20450893; 20558158; 20636478; 21292165; 21554241; 21791414; 22231169; 23251465; 23428800; 23720779; 23926298; 24395787; 24632852; 24676687; 24997451; 25931585; 26378614; 35015571; 37043557; 37437018 73 1 0 may contribute to SNCA accumulation; inhibits S6K dephosphorylation thus inhibiting the mTOR/S6K pathway +SERINC3 SERINC3 Cell surface; Membrane protein, integral; Membrane protein, multi-pass Q13530 10955 20q13.12 human S380-p 1255792401 ILGDTTTsGASDEED Serinc molecular association, regulation AP1M1(INDUCES); AP2M1(INDUCES) 30135209 1 1 0 Mu subunits of AP-1 and AP-2 fused to MBP +Plk2 PLK2 EC 2.7.11.21; KINASE; Kinase, protein; Protein kinase, Other; Protein kinase, Ser/Thr (non-receptor); Tumor suppressor Q9R012 83722 2q14 rat T236-p 25790901 PLEHRRRtICGTPNY Pkinase enzymatic activity, induced 20802490 2 0 1 +EFNB2 EFNB2 Ligand, receptor tyrosine kinase; Membrane protein, integral P52799 1948 13q33.3 human Y316-p 447830 GDYGHPVyIVQEMPP protein stabilization; protein conformation 12606549 3 9 121 +Rcan1 RCAN1 Inhibitor Q6IN33 266766 11q11 rat S108-p 456022 PDKQFLIsPPASPPV Calcipressin enzymatic activity, induced neural plasticity 32084406 7 34 5 induces calcineurin activity and hence LTD +Ppp2r5d PPP2R5D Motility/polarity/chemotaxis; PHOSPHATASE; Protein phosphatase, regulatory subunit Q7TNL5 21770 17 22.9 cM|17 C mouse S81-p 468499 VKKERRQsSFPFNLN enzymatic activity, induced 20106966 3 30 105 +Golga3 GOLGA3 Vesicle P55937 269682 5 F|5 53.36 cM mouse S174-p 487482 VKRHRERsSQPATKM apoptosis, altered 17888676 1 0 0 protected against Brefeldin-A-induced apoptosis, but not Fas-mediated apoptosis. +ACTB ACTB Cytoskeletal; Motility/polarity/chemotaxis P60709 60 7p22.1 human K284-sm 2894412 TTFNSIMkCDVDIRK Actin intracellular localization 19635839 1 1 0 nuclear localization +Hhex HHEX DNA-binding; Transcription factor F7F7Q9 rat S139-p 7430500 FETQKYLsPPERKRL Homeodomain cell cycle regulation; cell growth, induced 28927755 2 2 1 neointima formation ex vivo +SKAP1 SKAP55 Adaptor/scaffold; Motility/polarity/chemotaxis Q86WV1 8631 17q21.32 human Y295-p 460296 TRRKGVDyASYYQGL molecular association, regulation cell adhesion, altered; transcription, altered SLP76(DISRUPTS) 16461356 1 0 0 mutation of this site downregulates activity of IL-2 promoter and cytokine production +Bcl2l1 Bcl-xL Apoptosis; Autophagy; Membrane protein, integral; Mitochondrial P53563 24888 3q41 rat S62-p 449099 PSWHLADsPAVNGAT apoptosis, altered 18951975 18 1 0 +BUB1B BUB1B EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, Other; Protein kinase, Ser/Thr (non-receptor); Tumor suppressor O60566 701 15q15.1 human S670-p 3207630 TLSIKKLsPIIEDSR molecular association, regulation; phosphorylation cell cycle regulation; cytoskeletal reorganization PPP2R5A(INDUCES); PPP2CA(INDUCES) 19015317; 20016069; 23079597; 23345399; 33207204 9 35 0 pS670 Ab delayed anaphase onset in vivo and in vitro; regulates chromosome congression; chromosome segregation during mitosis and mitotic progression; T680 is independent of attachment status and may correlate with lack of interkinetochore tension.; regulates KNL1 phosphorylation; phosphorylated at kinetochores at the onset of mitosis; kinetochore-microtubule attachment +SCN5A SCN5A Channel, sodium; Membrane protein, integral; Membrane protein, multi-pass Q14524 6331 3p22.2 human S1934-p 40413914 LFRQQAGsGLSEEDA activity, induced; molecular association, regulation FGF13(DISRUPTS); Calmodulin(DISRUPTS) 28882890 3 3 0 impairs FGF13-dependent regulation of NaV1.5 channel inactivation +Ppp2r1a PPP2R1A Motility/polarity/chemotaxis; PHOSPHATASE; Protein phosphatase, regulatory subunit Q5XI34 117281 1q12 rat T268-p 31006103 YMVADKFtELQKAVG molecular association, regulation; protein conformation PPP2CA(DISRUPTS) 24465463 1 1 0 defect in holoenzyme assembly +Arhgap35 GRF-1 GAP; GAP, Rac/Rho; Motility/polarity/chemotaxis; Transcription factor; Tumor suppressor Q91YM2 232906 7|7 A2 mouse Y1105-p 448941 RNEEENIySVPHDST RhoGAP_pG1_pG2 molecular association, regulation RASA1(INDUCES) 9819392 5 83 3224 +PGR PR DNA-binding; Nuclear receptor; Transcription factor P06401 5241 11q22.1 human K531-sm 2890601 GYQAAVLkEGLPQVY Prog_receptor sumoylation; protein stabilization; intracellular localization; protein conformation transcription, inhibited 17020914 1 0 0 induces sumoylation at other sites +CLOCK CLOCK ACETYLTRANSFERASE; Acetyltransferase; DNA-binding; EC 2.3.1.48; Transcription factor O15516 9575 4q12 human S437-p 11087839 PSASSRSsRKSSHTA protein degradation 19946213 1 0 0 +Rara RARA DNA-binding; Nuclear receptor; Oncoprotein; Transcription factor P11416 19401 11 D|11 62.76 cM mouse K347-m3 2363104 QDLEQPDkVDMLQEP Hormone_recep molecular association, regulation transcription, induced RXRB(INDUCES); N-CoR1(INDUCES); RIP140(INDUCES); PCAF(INDUCES) 17205979 2 2 0 +Mknk1 Mnk1 EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, CAMK; Protein kinase, Ser/Thr (non-receptor); Translation O08605 17346 4|4 D1 mouse T344-p 447623 APERGLPtPQVLQRN enzymatic activity, induced translation, altered; cell growth, altered 18055695 3 4 14 +TOPORS TOPORS Cell cycle regulation; EC 6.3.2.-; EC 6.3.2.19; Ligase; SUMO LIGASE; SUMO conjugating system; SUMO ligase; UBIQUITIN LIGASE; Ubiquitin conjugating system; Ubiquitin ligase Q9NS56 10210 9p21.1 human T515-p 25756871 EKMETVKtQEQEQSY molecular association, regulation DNA repair, induced BRCA2(INDUCES) 35061896 1 0 1 RAD51 SUMOylation is required for HR-mediated DSB repair, GFP-TOPORS-WT restored the interaction between RAD51 and BRCA2, but the T515A mutant restored to a lesser degree +FOXO1 FOXO1A DNA-binding; Nuclear receptor co-regulator; Oncoprotein; Transcription factor Q12778 2308 13q14.11 human K262-ac 4253200 ASMDNNSkFAKSRSR molecular association, regulation; intracellular localization; phosphorylation carcinogenesis, inhibited; apoptosis, induced; transcription, inhibited DNA(DISRUPTS) 18786403; 20519497; 27132507 7 2 0 +H3C1 H3 DNA-binding P68431 8350 6p22.2 human S28-p 455677 ATKAARKsAPATGGV Histone molecular association, regulation; intracellular localization chromatin organization, altered; cell differentiation, induced; transcription, induced 14-3-3 zeta(INDUCES); HBXAP(DISRUPTS) 18418070; 20864036; 21282660; 21820363; 34635673 50 18 0 +Fos Fos DNA-binding; Motility/polarity/chemotaxis; Oncoprotein; Transcription factor P12841 314322 6q31 rat S374-p 448482 PSSDSLSsPTLLAL_ protein stabilization; protein conformation; phosphorylation cell cycle regulation; transcription, altered 12134156; 12629509; 17223854; 8622865 12 3 0 +DOK1 DOK1 Adaptor/scaffold; Motility/polarity/chemotaxis Q99704 1796 2p13.1 human S450-p 454885 SHNSALYsQVQKSGA cell motility, induced; cell growth, inhibited 15574499 1 0 2 +GAB1 GAB1 Adaptor/scaffold; Motility/polarity/chemotaxis Q13480 2549 4q31.21 human Y83-p 25655003 KKEFENSyIFDINTI PH cytoskeletal reorganization 22751113 2 0 0 +SGK1 SGK1 EC 2.7.11.1; KINASE; Kinase, protein; Motility/polarity/chemotaxis; Protein kinase, AGC; Protein kinase, Ser/Thr (non-receptor) O00141 6446 6q23.2 human S78-p 448430 ANPSPPPsPSQQINL cell cycle regulation 11254654 6 2 0 +KCNJ12 KCNJ12 Membrane protein, integral; Membrane protein, multi-pass Q14500 3768 17p11.2 human T38-p 3053610 FGNGKVHtRRRCRNR IRK_N activity, inhibited 12234954 1 0 0 +CFTR CFTR Channel, chloride; EC 3.6.3.49; Hydrolase; Membrane protein, integral; Membrane protein, multi-pass; Transporter; Transporter, ABC family P13569 1080 7q31.2 human S768-p 455300 LQARRRQsVLNLMTH CFTR_R activity, induced; molecular association, regulation; intracellular localization; enzymatic activity, inhibited; activity, inhibited 14-3-3 beta(INDUCES); CFTR(INDUCES) 14602047; 15657296; 19095655; 19328185; 19419994; 20952391; 26888287; 28242698 14 4 0 cell surface CFTR +Ppargc1a PGC-1 alpha Nuclear receptor co-regulator; Transcription, coactivator/corepressor O70343 19017 5|5 C1 mouse T177-p 486319 NHTHRIRtNPAIVKT transcription, altered 17609368 1 1 0 +Kcnq2 Kv7.2 Channel, potassium; Membrane protein, integral; Membrane protein, multi-pass O88943 170848 3q43 rat T217-p 457689 RMDRRGGtWKLLGSV Ion_trans; TM activity, induced 12754513 3 1 0 Mutants showed reduced currents induced by acetylcholine. +PAX3/FOXO1 PAX3-FOXO1 AAC50053 2308 13q14.11 human S437-p 38489513 SPRRRAAsMDNNSKF protein stabilization 31888889 1 1 11 +Pdlim4 RIL Cytoskeletal P70271 30794 11 B1.3|11 32.13 cM mouse S119-p 468635 PATSRRSsVSGISLE cell growth, inhibited 21644927 2 29 10 +CSNK1A1 CK1A EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, CK1; Protein kinase, Ser/Thr (non-receptor) P48729 1452 5q32 human S242-p 11333101 KISEKKMsTPVEVLC Pkinase molecular association, regulation 14-3-3 eta(INDUCES) 19860830 1 0 0 +Prkcd PKCD EC 2.7.11.13; KINASE; Kinase, protein; Nuclear receptor co-regulator; Protein kinase, AGC; Protein kinase, Ser/Thr (non-receptor); Protein kinase, tyrosine (non-receptor); Tumor suppressor P28867 18753 14 B|14 18.82 cM mouse S662-p 447580 QEAFHGFsFVNPKFE Pkinase_C intracellular localization 15731106 11 59 76 +Rab3ip RAB3IP GEF; GEF, Rab Q62739 29885 7q22 rat S250-p 482771 VLSSSPTsPTQEPLA Sec2p activity, induced; molecular association, regulation; protein conformation; enzymatic activity, induced exocytosis, induced RAB11A(DISRUPTS); RAB8A(INDUCES) 25535387 1 16 1 induces GEF activity of RAB3IP, induces RAB8 activity +BIRC5 Survivin Apoptosis O15392 332 17q25.3 human K129-ac 25558401 KEFEETAkKVRRAIE molecular association, regulation; intracellular localization STAT3(INDUCES); Survivin(INDUCES); Exportin-1(DISRUPTS) 20826784; 28384094 2 1 0 +SNAP25 SNAP-25 Vesicle P60880 6616 20p12.2 human T29-p 23939101 ADESLEStRRMLQLV exocytosis, induced 22311984 2 3 0 +Rps6kb1 p70S6K iso2 EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, AGC; Protein kinase, Ser/Thr (non-receptor); Translation P67999-2 83840 10q26 rat T421-p 448358 RFIGSPRtPVSPVKF activity, induced cell growth, altered 16195541 106 37 109 PI3K, Akt and mTOR activation are required for 5-HT-induced proliferatioin. Wortmanin LY294002 and NL-71-101 dose-dependently inhibited 5HT induced proliferation. +HNRNPUL1 E1B-AP5 RNA splicing; RNA-binding Q9BUJ2 11100 19q13.2 human R645-m1 12191850 NRGGFQNrGGGSGGG molecular association, regulation; intracellular localization NBS1(INDUCES) 26020839 1 5 25 ecruitment at sites of damage +SESN2 SESN2 P58004 83667 1p35.3 human S254-p 1869992400 NNSGGFEsARDVEAL PA26 molecular association, regulation; intracellular localization autophagy, induced ATP5A1(INDUCES) 32854424 1 1 0 +XRCC6 Ku70 DNA repair, damage; DNA-binding; EC 3.6.4.-; EC 4.2.99.-; Helicase; Nuclear receptor co-regulator; RNA-binding P12956 2547 22q13.2 human K542-ac 458922 NPEGKVTkRKHDNEG Ku_C molecular association, regulation; intracellular localization cell growth, induced; apoptosis, induced; apoptosis, inhibited BAX(INDUCES); BAX(DISRUPTS) DNA(DISRUPTS) 15023334; 17545612; 28238784 3 1 0 +IKBKE IKKE EC 2.7.11.10; Inhibitor; KINASE; Kinase, protein; Protein kinase, Other; Protein kinase, Ser/Thr (non-receptor) Q14164 9641 1q32.1 human T501-p 34434402 ELRSRLRtLAEVLSR TBK1_CCD1 phosphorylation; enzymatic activity, induced signaling pathway regulation 24882218 1 0 0 IFN signaling +PGR PR DNA-binding; Nuclear receptor; Transcription factor P06401 5241 11q22.1 human S190-p 447986 KVLPRGLsPARQLLL Prog_receptor transcription, induced 8662865 6 2 0 +ASAP3 DDEFL1 GAP; GAP, ARF; Motility/polarity/chemotaxis Q8TDY4 55616 1p36.12 human Y34-p 28704100 FAAKMPRyRGAALAR BAR_3 intracellular localization; protein conformation; enzymatic activity, induced cell motility, induced; cytoskeletal reorganization; signaling pathway regulation 23776207 1 1 0 EGF signaling pathway +CENPT CENPT DNA replication Q96BT3 80152 16q22.1 human T27-p 472114 LDTADPRtPRRPRSA CENP-T_N intracellular localization cell cycle regulation 21529714 2 6 35 localization of Ndc80/Hec1, controls kinetochore assembly, increases cell viability +CD93 CD93 Cell adhesion; Membrane protein, integral Q9NPY3 22918 20p11.21 human Y628-p 1031156 PQNAADSySWVPERA molecular association, regulation cell motility, induced; cell adhesion, induced CBL(INDUCES) 26848865 1 2 1 CD93 binds to Cbl inducing phosphorylation on tyrosine 774 of CBL +KCNA3 Kv1.3 Channel, potassium; Membrane protein, integral; Membrane protein, multi-pass P22001 3738 1p13.3 human Y499-p 451294 EGEEQSQyMHVGSCQ activity, induced; activity, inhibited cell growth, induced 11812778; 19166614; 26655221 3 0 0 +IRF2BP2 IRF2BP2 Transcription, coactivator/corepressor Q7Z5L9 359948 1q42.3 human S360-p 470316 TARKRKPsPEPEGEV activity, induced; intracellular localization 21887377 1 71 0 nuclear localization +GBF1 GBF1 GEF; GEF, ARF Q92538 8729 10q24.32 human Y899-p 34551124 TGLVRENyVWNVLLH molecular association, regulation; intracellular localization; protein conformation ARF1(INDUCES) 34870592 1 1 2 induces GALNT relocation +Olig1 OLIG1 Cell development/differentiation; Transcription factor Q9JKN5 50914 16|16 C3.3 mouse S138-p 25602100 GAPGRKLsKIATLLL HLH intracellular localization cell growth, induced; cell differentiation, induced 22639060 1 0 0 +TBXA2R TXA2-R GPCR, family 1; Membrane protein, integral; Membrane protein, multi-pass; Receptor, GPCR P21731 6915 19p13.3 human S324-p 3061802 RRLQPRLsTRPRSLS molecular association, regulation; activity, inhibited 24490858 2 0 0 desensitization of thromboxane receptor to agonist binding +MAP4 MAP4 Cytoskeletal; Motility/polarity/chemotaxis P27816 4134 3p21.31 human K998-ac 62495520 KVQIVSKkVSYSHIQ Tubulin-binding cytoskeletal reorganization 28002468 1 1 0 +Ank3 ANK3 iso4 Adaptor/scaffold; Motility/polarity/chemotaxis XP_006513193 11735 10 B5.3|10 36.1 cM mouse S1982-p 15718927 PKSDKGHsPEDDWTE molecular association, regulation; protein conformation neural plasticity; signaling pathway regulation SPTBN4(INDUCES) 31451636 1 4 0 targeting of SPTBN4 into the palasma membrane is reduced in S1982A mutatnt +GJA8 GJA8 Channel, misc.; Membrane protein, integral; Membrane protein, multi-pass P36381 395846 chicken S364-p 465560 KAEEEVVsDEVEGPS protein degradation; protein stabilization 10702244; 18649174 2 1 0 phosphorylation of this site blocks Cx50 from the cleavage by caspase-3 +CSF3R GCSFR Membrane protein, integral; Receptor, cytokine Q99062 1441 1p34.3 human K655-ub 9381807 LCCSPNRkNPLWPSV protein degradation; receptor internalization, induced; intracellular localization; phosphorylation cell growth, inhibited; cell growth, induced; cell differentiation, induced; signaling pathway regulation 17363902; 19453968 2 0 0 regulates production of neutrophilic granulocytes, regulates STAT5 activation; inhibits STAT5 activation +NF2 Merlin Cytoskeletal; Motility/polarity/chemotaxis; Tumor suppressor P35240 4771 22q12.2 human S518-p 448282 DTDMKRLsMEIEKEK ERM_C molecular association, regulation; ubiquitination; intracellular localization; protein conformation; activity, inhibited; phosphorylation cell cycle regulation; carcinogenesis, induced; transcription, altered; cell growth, induced; cell motility, altered; cytoskeletal reorganization; cell adhesion, altered; cell growth, altered DDB1(DISRUPTS); CD44(DISRUPTS); Merlin(DISRUPTS); AMOT(DISRUPTS); SPTAN1(INDUCES); LIN28B(DISRUPTS); TUBA4A(DISRUPTS); PIK3R2(DISRUPTS); VPRBP(INDUCES); 53BP2(DISRUPTS); Merlin(INDUCES); YAP1(DISRUPTS); Ezrin(INDUCES); Src(DISRUPTS); MED28(DISRUPTS); Hrs(DISRUPTS); VPRBP(DISRUPTS); LRP6(DISRUPTS); LATS1(INDUCES) 11703924; 11782491; 14724586; 14981079; 15378014; 15743831; 16267393; 16652148; 17175165; 17566081; 18071304; 18835652; 20178741; 21750658; 22516197; 25925953; 26997273; 27285107; 33058421; 36809290 33 41 1 cell-cell contact dephosphorylates; phosphorylation of this site increases intramolecular association of the N-terminal (FERM) domain with the C-terminal tail- in vitro data; increases phosphorylation of S10; inhibits ubiquitination and LATS1/YAP/TAZ phosphorylation +KLF16 KLF16 C2H2-type zinc finger protein; DNA-binding Q9BXK1 83855 19p13.3 human Y10-p 22874704 AAVACVDyFAADVLM activity, induced transcription, inhibited SIN3A(INDUCES) 22203677 1 0 0 +ARHGEF2 ARHGEF2 GEF; GEF, Rac/Rho; Motility/polarity/chemotaxis Q92974 9181 1q22 human S143-p 10991696 GSRRGRSsLSLAKSV molecular association, regulation; intracellular localization cytoskeletal reorganization TUBB2B(DISRUPTS) 21513698 2 7 4 inhibits microtubule binding and stabilization, acetylation, regulates cell polarization +Piwil2 PIWIL2 Apoptosis; Cancer Testis Antigen (CTA) Q8CDG1 57746 14|14 D2 mouse R74-m1 9859904 VGLVSMFrGMGLDTA molecular association, regulation; intracellular localization TDRKH(INDUCES); TDRD9(INDUCES); TDRD1(INDUCES) 19584108 1 1 1 +Ripk3 RIPK3 EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, Ser/Thr (non-receptor); Protein kinase, TKL Q9QZL0 56532 14|14 C3 mouse S232-p 23003800 AELVDKTsLIRETVC Pkinase activity, induced; molecular association, regulation; intracellular localization; protein conformation; enzymatic activity, induced; phosphorylation apoptosis, induced; apoptosis, inhibited ZBP1(INDUCES); MLKL(INDUCES) 23612963; 24902902; 25459880; 26283397; 27819681; 31511692; 33206046; 35580168; 35648750 25 7 0 +SMURF2 SMURF2 EC 6.3.2.-; EC 6.3.2.19; Ligase; UBIQUITIN LIGASE; Ubiquitin conjugating system; Ubiquitin ligase Q9HAU4 64750 17q23.3-q24.1 human T249-p 27457334 MSRTHLHtPPDLPEG ubiquitination carcinogenesis, inhibited; signaling pathway regulation 35017630 2 2 0 induces TGFBR1 ubiquitination and degradation, thus regulating the TGF-?-SMAD2/3 pathway +Grin2a NMDAR2A Channel, ligand-gated; Membrane protein, integral; Membrane protein, multi-pass P35436 14811 16 A1|16 5.28 cM mouse S1462-p 3597310 KKMPSIEsDV_____ NMDAR2_C molecular association, regulation PSD-95(NOT_REPORTED) 17179037 1 2 0 effects PKC potentiation of current +P2RX3 P2X3 Channel, ligand-gated; Membrane protein, integral; Membrane protein, multi-pass P56373 5024 11q12.1 human T196-p 458893 GNLLPNLtARDMKTC P2X_receptor receptor desensitization, altered 16226373 1 0 1 +RELA NFkB-p65 DNA-binding; Nuclear receptor co-regulator; Transcription factor Q04206 5970 11q13.1 human K314-ub 25087017 ETFKSIMkKSPFSGP transcription, inhibited 21706061 1 1 0 inhibits acetylation +CERS2 LASS2 DNA-binding; Membrane protein, integral; Membrane protein, multi-pass; Transferase Q96G23 29956 1q21.3 human S248-p 1872840300 SSDYLLEsAKMFNYA TRAM_LAG1_CLN8 carcinogenesis, inhibited; signaling pathway regulation 33852174 1 0 0 LASS2 S248A mutant inhibits ?-catenin ubiquitination and degradation and inhibits Wnt/?-catenin signaling pathway +IRAK1 IRAK1 EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, Ser/Thr (non-receptor); Protein kinase, TKL P51617 3654 Xq28 human S173-p 21041601 SLWPPPPsPAPSSTK molecular association, regulation; enzymatic activity, induced transcription, induced PIN1(INDUCES) 21743479; 27790836 2 0 0 +SRPK1 SRPK1 EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, CMGC; Protein kinase, Ser/Thr (non-receptor) Q96SB4 6732 6p21.31 human S587-p 25724400 LIVAGKYsKEFFTKK Pkinase intracellular localization RNA splicing, induced 22727668 1 1 0 translocation to the nucleus-regulation of E1A splicing +FIS1 FIS1 Membrane protein, integral; Mitochondrial Q9Y3D6 51024 7q22.1 human K149-sm 1883432306 LIGLAVSkSKS____ intracellular localization 34994490 1 0 0 more likely to localize to areas of the cell in which ER islocalized, SENP3-mediated deSUMOylation of Fis1 is required for mitophagy +Slc12a1 NKCC2 Membrane protein, integral; Membrane protein, multi-pass; Transporter; Transporter, SLC family P55014 20495 2 F1|2 61.23 cM mouse S126-p 478420 GPKVNRPsLLEIHEQ AA_permease_N activity, induced 17341212; 24808538 8 2 0 +Nbn NBS1 Cell cycle regulation; DNA repair, damage Q9R207 27354 4|4 A2 mouse S433-p 483547 KTPSYQLsPMKFPVA molecular association, regulation; intracellular localization carcinogenesis, induced; DNA repair, altered TRF2(DISRUPTS) 28216226; 34145035 4 40 0 +Epha3 EphA3 EC 2.7.10.1; KINASE; Kinase, protein; Membrane protein, integral; Protein kinase, TK; Protein kinase, tyrosine (receptor) P29319 13837 16|16 C1.3 mouse Y596-p 449912 KLPGLRTyVDPHTYE EphA2_TM enzymatic activity, induced 20697431 3 6 26 +ITK ITK EC 2.7.10.2; KINASE; Kinase, protein; Protein kinase, TK; Protein kinase, tyrosine (non-receptor) Q08881 3702 5q33.3 human Y512-p 447997 RFVLDDQyTSSTGTK PK_Tyr_Ser-Thr activity, induced; phosphorylation; enzymatic activity, induced signaling pathway regulation 31196981; 9312162 3 8 260 autophosphorylation at Y180 +CD36 CD36 Cell adhesion; Membrane protein, integral; Membrane protein, multi-pass P16671 948 7q21.11 human K472-ub 2363101 ACRSKTIk_______ protein degradation; molecular association, regulation; ubiquitination IRS1(INDUCES) 18316598; 29269414 2 0 0 inhibits insulin-stimulated IRS1 degradation, disrupts IRS1 interaction with CUL7 and Fyn, regulates IRS1 ubiquitination +MAPK14 P38A EC 2.7.11.24; KINASE; Kinase, protein; Protein kinase, CMGC; Protein kinase, Ser/Thr (non-receptor) Q16539 1432 6p21.31 human R49-me 1877038904 FDTKTGLrVAVKKLS Pkinase molecular association, regulation; phosphorylation; enzymatic activity, induced cell differentiation, induced MAPKAPK2(INDUCES); MKK3(INDUCES) 32429593 1 1 0 augments phosphorylation by MKK3 and enhances the activation of p38-alpha +PDZK1 PDZK1 Adaptor/scaffold Q5T2W1 5174 1q21.1 human S505-p 456807 MAKERAHsTASHSSS molecular association, regulation cell motility, induced; cell growth, induced PTGIR(INDUCES) 21653824 2 2 1 increases cell surface expression of functional PTGIR (aka hIP) leading to enhanced ligand binding and cAMP generation, increases endothelial cell migration and angiogenesis (tube formation) +OSBP2 OSBP2 Q969R2 23762 22q12.2 human S762-p 11171320 ECSKVMHsSPSSPSS Oxysterol_BP molecular association, regulation; protein conformation signaling pathway regulation Vimentin(INDUCES) 30925160 1 1 6 +EPHA2 EphA2 EC 2.7.10.1; KINASE; Kinase, protein; Membrane protein, integral; Protein kinase, TK; Protein kinase, tyrosine (receptor) P29317 1969 1p36.13 human S897-p 1244153 RVSIRLPsTSGSEGV receptor internalization, induced; protein stabilization; molecular association, regulation; intracellular localization; phosphorylation carcinogenesis, induced; cell motility, induced; signaling pathway regulation; DNA repair, induced; endocytosis, induced; cell growth, induced; apoptosis, inhibited; cell motility, altered; cytoskeletal reorganization DNAPK(INDUCES); ephexin-1(INDUCES); EGFR(INDUCES) 19573808; 25908849; 26158630; 33671073; 33907562; 34006609; 34018641; 34445353; 34484860; 35110502; 35668076; 36998455; 37063424; 37179400 25 32 171 induces chemoresistance; induces ERK and MDM2 phosphorylation, induces p53 degradation through the ERK/MDM2 pathway +Kcnn4 KCNN4 Channel, potassium; Membrane protein, integral; Membrane protein, multi-pass Q9QYW1 65206 1q21 rat S312-p 452143 YAKEMKEsAARLLQE CaMBD activity, inhibited 15243742 1 0 0 +ITGB4 ITGB4 Cell adhesion; Membrane protein, integral; Motility/polarity/chemotaxis; Receptor, misc. P16144 3691 17q25.1 human S1364-p 451655 PSGSQRPsVSDDTGC molecular association, regulation cell motility, altered; cytoskeletal reorganization Plectin-1(DISRUPTS) 17615294; 20870721 5 2 3 +STAT3 STAT3 DNA-binding; Motility/polarity/chemotaxis; Nuclear receptor co-regulator; Transcription factor P40763 6774 17q21.2 human K180-ub 10838906 DFNYKTLkSQGDMQD STAT_alpha phosphorylation 30741923 1 8 5 Hectd3-mediated polyubiquitination of Stat3 induces activating phosphorylation at Y705 and generation of ROR?t+IL17hi Th17 cells. +TP53 p53 Activator; DNA-binding; Motility/polarity/chemotaxis; Nuclear receptor co-regulator; Transcription factor; Tumor suppressor P04637 7157 17p13.1 human K120-ac 474514 FLHSGTAkSVTCTYS P53 activity, induced; acetylation; protein stabilization; molecular association, regulation; intracellular localization cell cycle regulation; apoptosis, altered; carcinogenesis, inhibited; cell growth, inhibited; apoptosis, induced; transcription, induced; signaling pathway regulation; transcription, altered; cell differentiation, induced; DNA repair, inhibited MDM2(DISRUPTS); DDX5(INDUCES) DNA(INDUCES) 17189187; 18485870; 19339993; 19377469; 19416725; 19494119; 19854137; 21148320; 21297583; 21303901; 21463657; 21525412; 22084066; 23431171; 23576563; 23677994; 24038750; 24120667; 24207022; 24219989; 25544752; 25961455; 26851285; 26882543; 27050276; 27208501; 28737768; 30940656; 31395738; 31680191; 32031738; 33789902; 35534985; 35872650 44 8 0 decrease of K120 acetylation shifts the balance from a proapoptotic pathway and induces p21 expression; HDAC6 ablation induces senescence p21 expression and inhibits cell growth, HDAC6 ablation inhibits HC proliferation after two-thirds partial hepatectomy (PHx); recruit p300, CBP, and TIP60 onto PD-1 promoter, p53-mediated PD-1 transcription; RNF8 promotes DSB repair and inhibits the pro-apoptotic activity and promotes DNA repair. ; 20, 164, 305, 320, 370/372/373, 381/382/386 K-R mutants diminsished transactivation, and selective regulation of target genes expression through distinct mechanisms; Increased p53 acetylation and apoptosis in the Ndufs4-deficient brain; iASPP displacement of p53 could affect acetylation of p53 and target gene selecivity +AXIN1 axin 1 Adaptor/scaffold; Tumor suppressor O15169 8312 16p13.3 human S75-p 4697306 LGYEPEGsASPTPPY AXIN1_TNKS_BD transcription, inhibited GSK3B(INDUCES) 17318175 1 11 20 +Pms2 PMS2 Cell cycle regulation; DNA repair, damage; EC 3.1.-.-; Hydrolase; Tumor suppressor P54279 18861 5 82.82 cM|5 G2 mouse T337-p 1881225900 ECVDINVtPDKRQIL molecular association, regulation MLH1(INDUCES) 36952545 1 0 0 +PRKCD PKCD EC 2.7.11.13; KINASE; Kinase, protein; Nuclear receptor co-regulator; Protein kinase, AGC; Protein kinase, Ser/Thr (non-receptor); Protein kinase, tyrosine (non-receptor); Tumor suppressor Q05655 5580 3p21.1 human S299-p 483986 NQVTQRAsRRSDSAS intracellular localization 17603046 1 18 21 localizes to the plasma and nuclear membrane +BACE1 BACE EC 3.4.23.46; Membrane protein, integral; Protease P56817 23621 11q23.3 human K501-ub 14991108 ADDISLLk_______ protein degradation; intracellular localization 20484053; 23109336; 27302062 3 0 0 +Prkaa2 AMPKA2 Autophagy; EC 2.7.11.1; EC 2.7.11.27; EC 2.7.11.31; KINASE; Kinase, protein; Protein kinase, CAMK; Protein kinase, Ser/Thr (non-receptor) Q8BRK8 108079 4|4 C6 mouse T172-p 448026 SDGEFLRtSCGSPNY Pkinase protein degradation; intracellular localization; phosphorylation; enzymatic activity, induced cell differentiation, inhibited; carcinogenesis, induced; carcinogenesis, inhibited; cell motility, induced; cell growth, inhibited; cell motility, inhibited; transcription, induced; signaling pathway regulation; transcription, altered; autophagy, induced; apoptosis, inhibited; autophagy, inhibited; cytoskeletal reorganization; transcription, inhibited 15866171; 17420279; 26091038; 28179583; 31930700; 31970902; 32051584; 32154661; 33516941; 33613155; 33779513; 33819291; 33869980; 33930463; 34006524; 34040167; 34493662; 34497121; 34588305; 34687898; 35061665; 35115380; 36715635 220 13 33 +NOS3 eNOS Amino Acid Metabolism - arginine and proline; EC 1.14.13.39; Oxidoreductase P29474 4846 7q36.1 human S114-p 448638 RKLQGRPsPGPPAPE molecular association, regulation; intracellular localization; enzymatic activity, induced ERK2(DISRUPTS) 16270749; 20213743; 35182051 22 4 0 +VIL1 Villin Actin-binding; Motility/polarity/chemotaxis P09327 7429 2q35 human Y64-p 3176603 SLSYDIHyWIGQDSS Gelsolin cytoskeletal reorganization 12269817 1 0 0 +Ppargc1a PGC-1 alpha Nuclear receptor co-regulator; Transcription, coactivator/corepressor O70343 19017 5|5 C1 mouse S615-p 15422176 RHRTHRNsPLYVRSR protein stabilization 23201126 1 0 3 +KEAP1 KEAP1 Endoplasmic reticulum; Motility/polarity/chemotaxis; Transcription regulation; UBIQUITIN LIGASE; Ubiquitin conjugating system Q14145 9817 19p13.2 human K551-ub 1883516302 WTFVAPMkHRRSALG protein degradation 36163178 1 0 0 +RAD17 RAD17 Cell cycle regulation O75943 5884 5q13.2 human S646-p 447755 ETWSLPLsQNSASEL molecular association, regulation; phosphorylation cell cycle regulation; cell growth, altered RAD1(INDUCES); SMG7(INDUCES); claspin(INDUCES) 11418864; 11687627; 16885023; 33820915 9 0 0 +RBM8A RBM8A RNA splicing; RNA-binding; Spliceosome; Translation Q9Y5S9 9939 1q21.1 human S166-p 456534 RRGGRRRsRSPDRRR molecular association, regulation RNA splicing, altered UPF3B(DISRUPTS); NCBP1(DISRUPTS); THOC4(DISRUPTS); TAP(DISRUPTS); RPL22(DISRUPTS) 16100109 2 8 3 Phosphorylation is required for release downstream factors. Phosphorylation interferes with RBM8A's arginine methylation in vitro (by rat PRMT1) and in vivo. +CHRM2 mAChR M2 GPCR, family 1; Membrane protein, integral; Membrane protein, multi-pass; Receptor, GPCR P08172 1129 7q33 human S309-p 459107 TQDENTVsTSLGHSK 7tm_1 receptor desensitization, altered; receptor internalization, altered 9162044 3 0 0 Mutation of 4 S/T to A eliminates receptor desensitization in response to carbachol treatment (as measured by isoproterenol-stimulated cAMP production after pretreatment with carbachol).; Mutation of S286 T287 S288 S290 to A caused a faster rate and a greater extent of receptor internalization after agonist stimulation (transients only, not observed in stables). Mutation of all 8 sites prevented internalization (in both transients and stables). +ERBB2 HER2 EC 2.7.10.1; KINASE; Kinase, protein; Membrane protein, integral; Oncoprotein; Protein kinase, TK; Protein kinase, tyrosine (receptor) P04626 2064 17q12 human S1151-p 3178974 DVRPQPPsPREGPLP carcinogenesis, induced; transcription, induced; signaling pathway regulation 35637411 1 8 45 induces the PI3K/AKT/NFkB p65 pathway +Myh9 MYH9 Actin-binding; Motility/polarity/chemotaxis; Motor Q8VDD5 17886 15 E1|15 36.81 cM mouse S1916-p 451181 AMNREVSsLKNKLRR Myosin_tail_1 exocytosis, induced; cell motility, induced; cytoskeletal reorganization 22025714; 35764499 11 3 8 +Cttn Cortactin Actin-binding; Cytoskeletal; Motility/polarity/chemotaxis Q60598 13043 7|7 F5 mouse Y541-p 13261767 YGLFPANyVELRQ__ SH3_9 molecular association, regulation MTUS2(DISRUPTS) 27451391 1 2 20 Y497, Y499, Y541 are major residues for interaction +MAP3K11 MLK3 EC 2.7.11.25; KINASE; Kinase, protein; Protein kinase, Ser/Thr (non-receptor); Protein kinase, TKL Q16584 4296 11q13.1 human S548-p 4269787 GQAWGRQsPRRLEDS enzymatic activity, inhibited; phosphorylation cell cycle regulation; carcinogenesis, inhibited; cell growth, inhibited 35843311 1 8 0 inhibits JNK and SEK1 phosphorylation +DNMT1 DNMT1 Amino Acid Metabolism - cysteine and methionine; Cell development/differentiation; EC 2.1.1.37; METHYLTRANSFERASE; Methyltransferase; Methyltransferase, DNA; Transcription regulation P26358 1786 19p13.2 human S154-p 476108 AKPEPSPsPRITRKS acetylation; protein stabilization; enzymatic activity, induced transcription, altered 21565170; 35246513 3 28 4 decreased stability in 154A mutant after treatment with 5'-Aza-2-Deoxycytidine; regulates MRTF-A acetylation +DGCR8 DGCR8 Nucleolus; RNA processing; RNA-binding Q8WYQ5 54487 22q11.21 human S493-p 25735895 NQKLITLsVQDAPTK protein stabilization 24239349 0 1 1 +Rigi RIGI EC 3.6.4.13; Hydrolase Q6Q899 230073 4|4 A5 mouse K146-m1 1883825701 IRQIRDTkGRMAGAE CARD_2 molecular association, regulation carcinogenesis, induced; signaling pathway regulation AMPKA1(INDUCES); STAT3(DISRUPTS) 36333807 1 1 0 RIGI demethylation inhibited IL-6-STAT3 signaling; demethylation of RIG-I to enhances RIGI-STAT3 association; JMJD4 and RIGI co-operatively inhibit DEN-induced hepatocarcinogenesis and steatosis; methylated RIG-I associates with AMPKA1 to inhibit HMGCR phosphorylation and promote cholesterol synthesis and NAFLD progression +Prkcd PKCD EC 2.7.11.13; KINASE; Kinase, protein; Nuclear receptor co-regulator; Protein kinase, AGC; Protein kinase, Ser/Thr (non-receptor); Protein kinase, tyrosine (non-receptor); Tumor suppressor P09215 170538 16p16 rat Y155-p 447575 IKQAKIHyIKNHEFI intracellular localization; phosphorylation apoptosis, induced 24569990 11 0 0 +FOXL2 FOXL2 DNA-binding; Transcription factor P58012 668 3q22.3 human K124-ac 1876739201 REGGGERkGNYWTLD Forkhead molecular association, regulation cell cycle regulation Ku80(INDUCES); Ku70(INDUCES) 32332759 1 1 0 Sequestering of XRCC5/6 by acetylated FOXL2 during G2 allows HR to occur preferentially over NHEJ +SAMHD1 SAMHD1 EC 3.1.4.- Q9Y3Z3 25939 20q11.23 human K595-sm 580826984 APLITPQkKEWNDST enzymatic activity, induced 34321470 1 2 0 SUMOylation of K595 is required for SAMHD1 to be antivirally active. +NFAT5 NFAT5 Transcription factor O94916 10725 16q22.1 human S158-p 2715403 LLDNSRMsCQDEGCG intracellular localization 18411282 2 2 0 +CDC25B CDC25B iso2 EC 3.1.3.48; Motility/polarity/chemotaxis; Nuclear receptor co-regulator; PHOSPHATASE; Protein phosphatase, dual-specificity P30305-2 994 20p13 human S103-p 9819903 GLCMDSPsPMDPHMA M-inducer_phosp protein degradation; ubiquitination 21807946 2 0 0 +VIPAS39 VIPAS39 Vesicle Q9H9C1 63894 14q24.3 human Y11-p 449005 TKGDEEEyWNSSKFK protein degradation; molecular association, regulation VPS33B(DISRUPTS) 22677173 1 8 320 +TBL1XR1 TBL1XR1 Nuclear receptor co-regulator; Transcription, coactivator/corepressor Q9BZK7 79718 3q26.32 human T203-p 2509602 WNLSENStSGSTQLV transcription, induced 18374649 1 0 0 +MDM2 MDM2 EC 6.3.2.-; EC 6.3.2.19; Inhibitor; Ligase; NEDDYLATION LIGASE; Neddylation Ligase; Nucleolus; Oncoprotein; UBIQUITIN LIGASE; Ubiquitin conjugating system; Ubiquitin ligase Q00987 4193 12q15 human S269-p 455458 SEEGQELsDEDDEVY molecular association, regulation cell growth, altered Rb(DISRUPTS) RNA(DISRUPTS) 15703839 3 1 0 decreases ability to bind poly-G RNA +Ets1 Ets-1 DNA-binding; Motility/polarity/chemotaxis; Oncoprotein; Transcription factor P27577 23871 9 A4|9 17.97 cM mouse S257-p 449319 DSFESVEsYDSCDRL Ets1_N_flank molecular association, regulation; acetylation; intracellular localization transcription, inhibited DNA(DISRUPTS) 30865889 4 0 1 induce acetylation of FOXO1 and suppress gluconeogenesis +STMN3 STMN3 Cytoskeletal Q9NZ72 50861 20q13.33 human S60-p 4698871 SFEVILKsPSDLSPE Stathmin intracellular localization cytoskeletal reorganization 22577147 2 4 0 +AURKA AurA EC 2.7.11.1; KINASE; Kinase, protein; Oncoprotein; Protein kinase, Other; Protein kinase, Ser/Thr (non-receptor) O14965 6790 20q13.2 human T288-p 448784 APSSRRTtLCGTLDY Pkinase intracellular localization; protein conformation; phosphorylation; enzymatic activity, induced cell cycle regulation; carcinogenesis, induced; autophagy, induced; cell motility, induced; apoptosis, inhibited; cytoskeletal reorganization 15173575; 16082213; 16246726; 16785988; 17545617; 20603326; 22094468; 23924325; 26165940; 27242098; 27721411; 31154600; 33744274; 33760847; 33771996; 33805672; 36372230 66 12 7 +NFKB2 NFkB-p100 DNA-binding; Oncoprotein; Transcription factor Q00653 4791 10q24.32 human S870-p 450167 KEDSAYGsQSVEQEA molecular association, regulation; protein processing IKKA(INDUCES); BTRC(INDUCES) 11239468; 15310758; 22388891 7 1 1 +Kif23 KIF23 Microtubule-binding; Motility/polarity/chemotaxis; Motor E9Q5G3 71819 9|9 B mouse S807-p 470674 VRHRRSRsAGSRWVD MKLP1_Arf_bdg intracellular localization cell cycle regulation; cytoskeletal reorganization 15199097 5 7 0 regulates cytokinesis +Slc10a2 ASBT Membrane protein, integral; Membrane protein, multi-pass; Transporter Q62633 29500 16q12.5 rat T339-p 453446 PMPSFQEtNKGFQPD protein degradation 15304498 2 0 0 +CDKL5 CDKL5 Cell cycle regulation; EC 2.7.11.22; KINASE; Kinase, protein; Protein kinase, CMGC; Protein kinase, Ser/Thr (non-receptor) O76039 6792 Xp22.13 human S308-p 15719610 RLLDRSPsRSAKRKP intracellular localization 27840050 1 2 0 cytoplasmic localization +Cacng2 Stargazin Channel, calcium; Membrane protein, integral; Membrane protein, multi-pass Q71RJ2 84347 7q34 rat S228-p 455313 SAITRIPsYRYRYQR molecular association, regulation neural plasticity PSD-95(INDUCES) 25843401 5 1 2 +AGER RAGE Cell cycle regulation; Membrane protein, integral; Motility/polarity/chemotaxis; Receptor, misc. Q15109 177 6p21.32 human S391-p 4731275 ERAELNQsEEPEAGE molecular association, regulation; protein conformation; phosphorylation DNA repair, induced; apoptosis, induced; signaling pathway regulation IRAK4(INDUCES); TIRAP(INDUCES); MYD88(INDUCES) 21829704; 25002577; 28977635 4 2 0 +PFKFB3 PFKFB3 Carbohydrate Metabolism - fructose and mannose; EC 2.7.1.105; EC 3.1.3.46; KINASE; Kinase, other; Motility/polarity/chemotaxis; PHOSPHATASE; Phosphatase (non-protein) Q16875 5209 10p15.1 human T463-p 468407 LMRRNSVtPLASPEP cell growth, induced 29967256 1 17 2 CDK6 phosphorylation of PFKFB3 may regulate glucose metabolism and be involved in breast cancer +Atp1a1 ATP1A1 EC 3.6.3.9; Hydrolase; Membrane protein, integral; Membrane protein, multi-pass; Transporter; Transporter, ion channel P06685 24211 2q34 rat Y542-p 458467 KDAFQNAyLELGGLG enzymatic activity, induced exocytosis, altered AP-2 alpha(DISRUPTS) 11859087 1 8 143 +ACADVL ACADVL EC 1.3.8.9; Lipid Metabolism - fatty acid; Mitochondrial; Oxidoreductase P49748 37 17p13.1 human K507-ac 40477505 LLLGEAGkQLRRRAG molecular association, regulation CRLS1(INDUCES) 25811481 1 0 0 both SIRT3 and SIRT5 KO show reduced afinity for CRLS1 +HMGA1 HMGA1 DNA-binding P17096 3159 6p21.31 human S36-p 455950 PRKQPPVsPGTALVG molecular association, regulation DNA(INDUCES) 17960875 2 50 19 Cdc2 phosphorylated HMGA1 has lower binding affinity than HIPK2 phosphorylated HMGA1. +CDT1 CDT1 DNA replication; DNA-binding; Motility/polarity/chemotaxis; Oncoprotein Q9H211 81620 16q24.3 human T358-p 1239966007 PPATEKLtTAQEVLA cell cycle regulation; cytoskeletal reorganization 30154187 1 1 0 regulates kTM stability +FN1 FN1 iso1 Cell adhesion; Motility/polarity/chemotaxis; Secreted; Secreted, signal peptide P02751-1 2335 2q35 human S2384-p 467903 VQADREDsRE_____ cell adhesion, induced 31291285 1 29 26 +ARRB2 ARRB2 iso2 Adaptor/scaffold P32120-2 281638 cow K293-sm 25350104 RGLALDGkLKHEDTN Arrestin_C molecular association, regulation AP-2 beta(INDUCES) 21118812 1 0 0 GPCR endocytosis induced +PI4K2A PI4K2A EC 2.7.1.67; Kinase, lipid; Motility/polarity/chemotaxis Q9BTU6 55361 10q24.2 human S51-p 468435 SGPSPPGsPGHDRER molecular association, regulation endocytosis, inhibited BRSK1(INDUCES); VACAMKL(INDUCES); TRIM3(INDUCES); CENTG1(INDUCES) 37314927 2 68 7 +TOP2B TOP2B iso2 Cell development/differentiation; DNA-binding; EC 5.99.1.3; Motility/polarity/chemotaxis; Nucleolus; Topoisomerase Q02880-2 7155 3p24.2 human S1130-p 23154509 HDDSSSDsGTPSGPD DNA_topoisoIV protein degradation; molecular association, regulation; ubiquitination carcinogenesis, induced BTRC(INDUCES) 32015321 1 1 1 +Crtc3 TORC3 Transcription, coactivator/corepressor Q91X84 70461 7|7 D3 mouse S62-p 3203139 LTQYHGGsLPNVSQL TORC_N molecular association, regulation transcription, inhibited 14-3-3 beta(INDUCES) 23033494 1 38 2 inhibits nuclear localization +Brsk2 BRSK2 EC 2.7.11.1; EC 2.7.11.26; KINASE; Kinase, protein; Protein kinase, CAMK; Protein kinase, Ser/Thr (non-receptor) Q69Z98 75770 7|7 F5 mouse T460-p 4734909 PKESPAGtPNPTPPS protein stabilization; enzymatic activity, inhibited; phosphorylation 23790753 1 2 2 inhibits axon branching (activated in BRSK2 18A mutant) +UNG UNG EC 3.2.2.27; Hydrolase P13051 7374 12q24.11 human Y8-p 460068 MIGQKTLySFFSPSP molecular association, regulation PCNA(DISRUPTS) 28746850 0 6 121 +SMURF1 SMURF1 EC 6.3.2.-; EC 6.3.2.19; Ligase; UBIQUITIN LIGASE; Ubiquitin conjugating system; Ubiquitin ligase Q9HCE7 57154 7q22.1 human K381-ub 964546162 YERDLVQkLKVLRHE protein degradation 21572392 1 1 0 +ERG ERG DNA-binding; Oncoprotein; Transcription factor P11308 2078 21q22.2 human K89-ac 56394102 PDECSVAkGGKMVGS molecular association, regulation carcinogenesis, induced; transcription, induced BRD4(INDUCES) 27223260 3 1 0 +OTUB1 OTUB1 DEUBIQUITINASE; EC 3.4.19.12; Protease; Ubiquitin conjugating system; Ubiquitin-specific protease Q96FW1 55611 11q13.1 human S18-p 3072783 QEPLGSDsEGVNCLA molecular association, regulation YpkA(INDUCES) 20553488 2 5 0 regulates bacterial uptake +H3C1 H3 DNA-binding P68431 8350 6p22.2 human K18-ac 465520 TGGKAPRkQLATKAA Histone molecular association, regulation; acetylation; methylation cell cycle regulation; carcinogenesis, induced; apoptosis, induced; transcription, induced; transcription, altered; DNA repair, induced; chromatin organization, altered; transcription, inhibited RCOR1(INDUCES); TIF1G(INDUCES) DNA(DISRUPTS) 12498683; 17560255; 18985155; 19196836; 19883641; 20720004; 21726812; 28953875; 31071955; 35222362; 35322029; 36060800 57 27 381 +RBBP8 CtIP EC 3.1.-.-; Transcription, coactivator/corepressor Q99708 5932 18q11.2 human S347-p 30992801 LDLNTSLsPSLLQPG enzymatic activity, induced 24837676 1 8 0 +Usp8 USP8 DEUBIQUITINASE; EC 3.4.19.12; Protease; Ubiquitin conjugating system; Ubiquitin-specific protease Q80U87 84092 2|2 F1 mouse T907-p 475072 TCRRRSRtFEAFMYL UCH enzymatic activity, induced cell growth, altered 17210635 1 0 0 increases de-ubiquitation activity towards E3-ligase Nrdp1 and the ErbB3 receptor +HIPK2 HIPK2 EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, CMGC; Protein kinase, Ser/Thr (non-receptor) Q9H2X6 28996 7q34 human S364-p 4783726 VCSTYLQsRYYRAPE Pkinase molecular association, regulation; intracellular localization; phosphorylation cell cycle regulation; cell growth, inhibited; transcription, inhibited SIAH2(INDUCES); PIN1(INDUCES) 23000554 1 10 325 +ZFYVE28 ZFYVE28 Cytoskeletal; Lipid-binding Q9HCC9 57732 4p16.3 human K87-ub 7250588 APRDFCVkFPEEIRH ubiquitination 19460345 1 10 124 +PIK3R1 PIK3R1 KINASE; Kinase, lipid; Motility/polarity/chemotaxis P27986 5295 5q13.1 human Y528-p 457097 IQRIMHNyDKLKSRI PI3K_P85_iSH2 molecular association, regulation; enzymatic activity, induced cell motility, altered SHP-2(INDUCES); IRS1(INDUCES) 16306077 1 3 6 +TNNI3 TNNI3 Actin-binding; Motility/polarity/chemotaxis; Motor P19429 7137 19q13.42 human S150-p 451822 TLRRVRIsADAMMQA Troponin activity, induced; molecular association, regulation cytoskeletal reorganization; signaling pathway regulation ACTB(DISRUPTS) 22456184; 22493448; 28018230 9 4 0 increases myofilament Ca(2+)-sensitive force development and blunts PKA-dependent desensitization +Prkcd PKCD EC 2.7.11.13; KINASE; Kinase, protein; Nuclear receptor co-regulator; Protein kinase, AGC; Protein kinase, Ser/Thr (non-receptor); Protein kinase, tyrosine (non-receptor); Tumor suppressor P09215 170538 16p16 rat T505-p 447511 FGENRAStFCGTPDY Pkinase enzymatic activity, induced 16361709; 18550549 51 21 108 +TP73 p73 DNA-binding; Transcription factor; Tumor suppressor O15350 7161 1p36.32 human K627-sm 2293700 KARKQPIkEEFTEAE protein degradation; intracellular localization cell cycle regulation; transcription, inhibited 10961991; 15572666 2 1 0 +CAD CAD Amino Acid Metabolism - alanine, aspartate and glutamate; EC 2.1.3.2; EC 3.5.2.3; EC 6.3.5.5; Hydrolase; KINASE; Ligase; Nucleotide Metabolism - pyrimidine; Transferase P27708 790 2p23.3 human S1406-p 451249 GAGGRRLsSFVTKGY MGS phosphorylation 17206380 4 35 5 inhibits phosphorylation of T456 +XRCC4 XRCC4 DNA repair, damage Q13426 7518 5q14.2 human S320-p 475981 HISAENMsLETLRNS XRCC4 DNA repair, induced 33503430 3 12 0 +Des desmin Cytoskeletal; Motility/polarity/chemotaxis P31001 13346 1 C4|1 38.85 cM mouse S7-p 466342 _MSQAYSsSQRVSSY transcription, altered; cell growth, altered 17381546 3 0 0 important for cardiomyogenesis +TP53 p53 Activator; DNA-binding; Motility/polarity/chemotaxis; Nuclear receptor co-regulator; Transcription factor; Tumor suppressor P04637 7157 17p13.1 human K321-ub 11263011 SSPQPKKkPLDGEYF P53_tetramer protein degradation; molecular association, regulation; intracellular localization KPNA4(DISRUPTS) 19927155 1 2 9 +ROS1 ROS EC 2.7.10.1; KINASE; Kinase, protein; Membrane protein, integral; Oncoprotein; Protein kinase, TK; Protein kinase, tyrosine (receptor) P08922 6098 6q22.1 human Y2274-p 454391 KNREGLNyMVLATEC molecular association, regulation SHP-1(INDUCES) 15456853 1 3 13 Mutation of Y2274 abolished ligand-dependent association of ROS with SHP-1. +COPS5 COPS5 Adaptor/scaffold; DEUBIQUITINASE; EC 3.4.-.-; Nuclear receptor co-regulator; Protease; Transcription, coactivator/corepressor; Translation Q92905 10987 8q13.1 human T205-p 1827354804 EGPSEYQtIPLNKIE enzymatic activity, inhibited signaling pathway regulation 31950832 1 1 0 NFkB signaling pathway +FOXO4 FOXO4 DNA-binding; Oncoprotein; Transcription factor P98177 4303 Xq13.1 human T451-p 448518 PIPKALGtPVLTPPT intracellular localization cell cycle regulation; transcription, induced 11689711; 15538382 3 3 0 +MAPT Tau iso8 ACETYLTRANSFERASE; Acetyltransferase; Cytoskeletal P10636-8 4137 17q21.31 human K174-ac 55529800 NATRIPAkTPPAPKT molecular association, regulation; protein stabilization Tau(INDUCES) 26390242; 35269542 5 1 0 hydrogen bonding interactions stabilize the acetylated Tau dimer, dimer stabilization and subsequent aggregation; promotes neurodegeneration and behavioral deficits +FOSB FosB DNA-binding; Transcription factor P53539 2354 19q13.32 human S27-p 465535 SAESQYLsSVDSFGS activity, induced; protein stabilization transcription, induced 16687504; 17241283 4 1 0 +Kcnd2 Kv4.2 Channel, potassium; Membrane protein, integral; Membrane protein, multi-pass Q63881 rat S537-p 4668100 CSRRHKKsFRIPNAN DUF3399 intracellular localization; phosphorylation 18795890 1 0 1 increases phosphorylation at T602 and T607 by ERK +POLI POLI DNA repair, damage; EC 2.7.7.7; Transferase Q9UNA4 11201 18q21.2 human K78-ub 50771305 SNPELKDkPLGVQQK IMS protein degradation 26370087 1 3 0 +NFKBIA IkB-alpha DNA-binding; Inhibitor P25963 4792 14q13.2 human K47-ub 4860400 EEYEQMVkELQEIRL protein degradation transcription, induced 9990853 2 1 0 +Exoc8 EXOC8 Vesicle O54924 245709 19q12 rat S276-p 182950103 EETKRALsDKRRREQ molecular association, regulation exocytosis, inhibited Sec5(DISRUPTS); EXOC8(DISRUPTS) 28325821 1 1 0 +GLUD1 GLUD1 Amino Acid Metabolism - alanine, aspartate and glutamate; Amino Acid Metabolism - arginine and proline; EC 1.4.1.3; Energy Metabolism - nitrogen; Mitochondrial; Other Amino Acids Metabolism - D-Glutamine and D-glutamate; Oxidoreductase P00367 2746 10q23.2 human S384-p 25739562 DILIPAAsEKQLTKS ELFV_dehydrog activity, induced; molecular association, regulation; enzymatic activity, induced carcinogenesis, induced; transcription, induced; signaling pathway regulation IKKB(INDUCES); NFkB-p65(INDUCES) 31447391 1 5 1 induces NF-kB activity and signaling +Ikzf1 Ikaros C2H2-type zinc finger protein; DNA-binding; Transcription factor Q03267 22778 11 A1|11 7.02 cM mouse T393-p 451353 SNSCQDStDTESNAE activity, inhibited cell cycle regulation DNA(DISRUPTS) 15024069 1 0 5 +SLC39A7 SLC39A7 Membrane protein, integral; Membrane protein, multi-pass; Transporter; Transporter, SLC family Q92504 7922 6p21.32 human S275-p 457019 RSTKEKQsSEEEEKE Zip activity, induced; phosphorylation exocytosis, induced; signaling pathway regulation 28205653; 31483418 2 19 9 maximal activation, SLC39A7 and Akt activation, zinc release and downstream effectors GSK3B, and p70 S6, phosphorylation of multiple kinases +NR3C1 GR DNA-binding; Mitochondrial; Nuclear receptor; Transcription factor P04150 2908 5q31.3 human S226-p 451796 IDENCLLsPLAGEDD GCR molecular association, regulation; intracellular localization; activity, inhibited transcription, induced; transcription, inhibited GRIP1(INDUCES) 12351702; 17440046; 20047289; 27013170; 28582465; 31974640 39 9 1 +GPM6A GPM6A Cell surface; Channel, calcium; Membrane protein, integral; Membrane protein, multi-pass P51674 2823 4q34.2 human Y251-p 7783489 DACRMQKyEDIKSKE cytoskeletal reorganization 25242528 1 1 1 neurite outgrowth +Mef2c MEF2C DNA-binding; Transcription factor Q8CFN5 17260 13 C3|13 43.68 cM mouse S110-p 4758829 ADDSVGHsPESEDKY HJURP_C molecular association, regulation PIN1(INDUCES) 20801874 1 5 2 Pin1 binding decreases MEF2C stability and its transcriptional activity +NR1H3 LXR-alpha DNA-binding; Motility/polarity/chemotaxis; Nuclear receptor Q13133 10062 11p11.2 human K434-sm 12004411 ALRLQDKkLPPLLSE molecular association, regulation transcription, inhibited DNA(INDUCES) 17218271 1 0 0 +DDB1 DDB1 DNA repair, damage Q16531 1642 11q12.2 human S645-p 7321234 LRTFRSLsTTNVFAC molecular association, regulation G-beta 2(DISRUPTS) 25982117 1 4 6 +Ctnnd1 CTNND1 Actin-binding; Adaptor/scaffold; Cell adhesion; G protein regulator, misc.; Motility/polarity/chemotaxis P30999 12388 2 D|2 49.45 cM mouse K625-ac 17391700 CFGAKKGkDEWFSRG cytoskeletal reorganization 16916647 0 1 0 +EGFR EGFR EC 2.7.10.1; KINASE; Kinase, protein; Membrane protein, integral; Oncoprotein; Protein kinase, TK; Protein kinase, tyrosine (receptor) P00533 1956 7p11.2 human Y1197-p 448060 STAENAEyLRVAPQS activity, induced; protein degradation; molecular association, regulation; receptor internalization, altered; intracellular localization; phosphorylation; enzymatic activity, induced carcinogenesis, induced; carcinogenesis, inhibited; cell motility, induced; cell growth, inhibited; transcription, induced; signaling pathway regulation; cell growth, induced; transcription, inhibited; cell growth, altered SH3KBP1(INDUCES); RASA1(INDUCES); GRB2(INDUCES); EGFR(INDUCES); SHC1(INDUCES); SHP-1(INDUCES); CBL(INDUCES) 10653583; 12177062; 1314835; 15708852; 16729043; 16943190; 2022651; 2022652; 21787862; 21918175; 23764002; 24430869; 26079946; 26290602; 26918609; 28102297; 3263271; 33947961; 33952697; 35184157; 35226996; 36012373; 37085908; 7506413; 8408058; 9733788 106 59 1028 +OTUB2 OTUB2 DEUBIQUITINASE; EC 3.4.19.12; Hydrolase; Ubiquitin-specific protease Q96DC9 78990 14q32.12 human K233-sm 1879841200 NILYAADkH______ protein stabilization; molecular association, regulation; intracellular localization carcinogenesis, induced TAZ(INDUCES); YAP1(INDUCES) 30472188 1 1 0 Enhances stem cell-like properties of breast cancer cells +CDT1 CDT1 DNA replication; DNA-binding; Motility/polarity/chemotaxis; Oncoprotein Q9H211 81620 16q24.3 human S143-p 1239966006 RVRALKAsAQDAGES cell cycle regulation; cytoskeletal reorganization 30154187 1 1 0 regulates kTM stability +RACGAP1 MgcRacGAP GAP; GAP, Rac/Rho Q9H0H5 29127 12q13.12 human S157-p 3211992 GSILSDIsFDKTDES molecular association, regulation; enzymatic activity, induced cell cycle regulation; cytoskeletal reorganization ECT2(INDUCES); PPP2CA(DISRUPTS) 19468302; 25486482; 27453045; 35477750 4 15 0 induces Rho GTPase activity +FOXP3 FOXP3 C2H2-type zinc finger protein; Cell cycle regulation; DNA-binding; Transcription factor Q9BZS1 50943 Xp11.23 human K250-ac 31914100 EQQLVLEkEKLSAMQ FOXP-CC protein stabilization 23644046 1 0 0 +Ksr1 KSR KINASE; Kinase, protein; Protein kinase, Ser/Thr (non-receptor); Protein kinase, TKL Q61097 16706 11 B5|11 46.74 cM mouse S443-p 449300 TTSSTPSsPAPFLTS intracellular localization; phosphorylation neural plasticity; signaling pathway regulation 21471251 2 0 0 ERK1/2 signaling +GNAQ G-alpha(q) G protein; G protein, heterotrimeric; G protein, heterotrimeric alpha G(q) P50148 2776 9q21.2 human S53-p 482964 GTGESGKsTFIKQMR G-alpha enzymatic activity, inhibited 17531806 1 1 0 inhibits G-alpha(q) signaling following infection of bacteria Yersinia pseudotuberculosis +MYB Myb DNA-binding; Oncoprotein; Transcription factor P10242 4602 6q23.3 human K480-ac 458942 ALAAQEIkYGPLKML Cmyb_C molecular association, regulation transcription, induced DNA(INDUCES) 10656693 1 1 0 +UFL1 UFL1 EC 6.3.2.-; Ligase; Tumor suppressor O94874 23376 6q16.1 human S462-p 15436603 DDDSDDEsQSSHTGK molecular association, regulation; enzymatic activity, induced DNA repair, induced NBS1(INDUCES) 30886146 1 4 9 activation of ATM signaling +Ikbke IKKE EC 2.7.11.10; Inhibitor; KINASE; Kinase, protein; Protein kinase, Other; Protein kinase, Ser/Thr (non-receptor) Q9R0T8 56489 1|1 E4 mouse S172-p 447631 DDDEKFVsVYGTEEY Pkinase enzymatic activity, induced 10421793 8 4 0 +GAB1 GAB1 Adaptor/scaffold; Motility/polarity/chemotaxis Q13480 2549 4q31.21 human Y259-p 448877 ASVDSSLyNLPRSYS molecular association, regulation CDK6(INDUCES) 19881549 2 29 488 promotes HGF-induced DNA synthesis +Plcg1 PLCG1 Carbohydrate Metabolism - inositol phosphate; EC 3.1.4.11; Motility/polarity/chemotaxis; Phospholipase Q62077 18803 2 H2|2 80.97 cM mouse Y783-p 447667 EGRNPGFyVEANPMP molecular association, regulation; protein conformation cell adhesion, altered PLCG1(INDUCES) 15657076; 15764700; 19917685; 26687682 92 42 558 +DHCR7 DHCR7 EC 1.3.1.21; Lipid Metabolism - steroid biosynthesis; Membrane protein, integral; Membrane protein, multi-pass; Oxidoreductase Q9UBM7 1717 11q13.4 human S14-p 4269796 PNIPKAKsLDGVTND enzymatic activity, induced 27520299 1 36 4 +PDCD6 PDCD6 O75340 10016 5p15.33 human K90-me 1881937801 SEFTGVWkYITDWQN protein stabilization carcinogenesis, induced; cell growth, induced; apoptosis, inhibited 35396512 1 1 0 K90R inhibits tumor growth and apoptosis, promotes cervical cancer growth under glucose deprivation mediated by AMPK activation +IRF5 IRF5 DNA-binding; Transcription factor Q13568 3663 7q32.1 human S158-p 27101102 QRMLPSLsLTEDVKW intracellular localization apoptosis, induced 22412986 1 1 0 nuclear localization- S158 requires an activator, while S435 and S446 do not. +Mpz myelin P0 Adaptor/scaffold; Membrane protein, integral P06907 24564 13q24 rat S228-p 458932 AMLDHSRsTKAASEK Myelin-PO_C cell adhesion, altered 17502419 2 1 0 +CCP110 CP110 Cell cycle regulation O43303 9738 16p12.3 human S372-p 9318022 PSPEPSMsPKMHRRR intracellular localization cell cycle regulation 12361598 1 17 3 +DCLRE1C Artemis DNA repair, damage; Deoxyribonuclease; EC 3.1.-.- Q96SD1 64421 10p13 human S648-p 38410203 TNADSQSsSDFEVPS molecular association, regulation; intracellular localization DNA repair, induced PAXIP1(INDUCES) 25512557 1 1 0 Artemis prevents end resection and promotes non-homologous end joining +ZFP64 ZFP64 C2H2-type zinc finger protein; DNA-binding; Transcription regulation Q9NTW7 55734 20q13.2 human S226-p 7322830 NKHLRIHsDERPFKC zf-H2C2_5 ubiquitination; intracellular localization carcinogenesis, induced; cell motility, induced; cell growth, induced; apoptosis, inhibited; transcription, induced 35219791 1 8 0 +SLC9A1 NHE1 Membrane protein, integral; Membrane protein, multi-pass; Motility/polarity/chemotaxis; Transporter; Transporter, SLC family P19634 6548 1p36.11 human S770-p 475073 MMRSKETsSPGTDDV activity, induced; protein stabilization; protein conformation 17209041; 23602949 6 2 0 phosphomimetic mutant was strongly stabilized and resulted in a more compact region which affects NHE1 activity. +Epor EPOR Membrane protein, integral; Receptor, cytokine P14753 13857 9 A3|9 7.93 cM mouse Y455-p 455532 PPHLKYLyLVVSDSG molecular association, regulation; receptor internalization, altered PIK3R2(INDUCES); PIK3R1(INDUCES) 19336760 8 0 0 required for optimal PIK3R1/2 binding +ETV5 ERM DNA-binding; Transcription factor P41161 2119 3q27.2 human S367-p 451201 PPYQRRGsLQLWQFL protein conformation transcription, induced 11682477 2 0 0 +TP53 p53 Activator; DNA-binding; Motility/polarity/chemotaxis; Nuclear receptor co-regulator; Transcription factor; Tumor suppressor P04637 7157 17p13.1 human K382-m2 4219800 QSTSRHKkLMFKTEG protein stabilization; molecular association, regulation; protein conformation p300(DISRUPTS); 53BP1(INDUCES) 18840612; 25651062; 33961797 3 1 0 +Gabrb3 GABRB3 Channel, chloride; Channel, ligand-gated; Membrane protein, integral; Membrane protein, multi-pass; Transporter; Transporter, ion channel P63080 14402 7 B5|7 33.53 cM mouse S433-p 450246 THLRRRSsQLKIKIP Neur_chan_memb molecular association, regulation; receptor desensitization, altered cytoskeletal reorganization AP-2 alpha(DISRUPTS) 14684872; 18184780; 26627235 13 0 3 increased dendritic spine density, alterations in GABRB3 expression, decreased social interaction and repetitive-like behavior in S408/9A mice +Tsc2 TSC2 Cell cycle regulation; GAP; GAP, misc.; Nuclear receptor co-regulator; Tumor suppressor Q61037 22084 17 A3.3|17 12.41 cM mouse S664-p 455575 KKASGPLsPPTGPPS Tuberin phosphorylation carcinogenesis, induced; signaling pathway regulation 35797217 9 9 1 induces 4E-BP1 and S6 phosphorylation thus regulating TORC1signaling, +STXBP5L STXBP5L Q9Y2K9 9515 3q13.33 human S771-p 15723219 CSSGKRLsSADVSKV protein degradation 25002582 1 2 0 ; in a multiple residue S->D mutant +PTPN11 SHP-2 EC 3.1.3.48; Motility/polarity/chemotaxis; PHOSPHATASE; Protein phosphatase, tyrosine (non-receptor) Q06124 5781 12q24.13 human Y580-p 448493 REDSARVyENVGLMQ molecular association, regulation; phosphorylation; enzymatic activity, induced carcinogenesis, induced; cell growth, induced; apoptosis, inhibited; cell motility, altered GRB2(INDUCES); SHP-2(INDUCES); Fyn(INDUCES) 11684012; 12531430; 20855525; 34657149 18 60 1189 +SIRT2 SIRT2 iso2 DEACETYLASE; Deacetylase; EC 3.5.1.- Q8IXJ6-2 22933 19q13.2 human S331-p 482809 PNPSTSAsPKKSPPP activity, inhibited cell cycle regulation 26303530 7 31 0 +Cnn3 calponin 3 Cytoskeletal; Motility/polarity/chemotaxis Q9DAW9 71994 3|3 G1 mouse S296-p 4776198 GTNGSEIsDSDYQAE molecular association, regulation cell differentiation, induced; cytoskeletal reorganization ACTA1(INDUCES) 23276748 2 4 9 +Socs3 SOCS3 Inhibitor O35718 12702 11|11 E2 mouse Y204-p 450446 VNGHLDSyEKVTQLP cell cycle regulation 31255914 5 2 12 +IRF3 IRF3 DNA-binding; Transcription factor Q14653 3661 19q13.33 human K77-ub 598897600 KPDLPTWkRNFRSAL IRF protein degradation; molecular association, regulation; ubiquitination autophagy, induced CALCOCO2(INDUCES) 29358709; 37330913 2 1 0 GPR108 and Smurf1 mediated degradation requires NDP52; NDP52-dependent autophagic degradation of phosphorylated IRF3; GPR108 interacts with Smurf1, followed by the recruitment of IRF3 during viral infection +Kcnj8 KCNJ8 Channel, potassium; Membrane protein, integral; Membrane protein, multi-pass Q63664 25472 4q44 rat S379-p 1458601 SELSHQNsLRKRNSM activity, inhibited 18048350 1 1 0 +Npr2 ANPB EC 4.6.1.2; Guanylyl cyclase; KINASE; Kinase, protein; Lyase; Membrane protein, integral; Nucleotide Metabolism - purine; Protein kinase, RGC; Protein kinase, dual-specificity (receptor); Receptor, misc. P16067 116564 5q22 rat T529-p 17557700 SSYGSLMtAHGKYQI PK_Tyr_Ser-Thr enzymatic activity, induced 20977274 1 1 0 +TRIM21 TRIM21 EC 6.3.2.-; Ligase; UBIQUITIN LIGASE; Ubiquitin conjugating system; Ubiquitin ligase P19474 6737 11p15.4 human K351-ac 1883534900 WEVDVTGkEAWDLGV enzymatic activity, induced 35770730 1 1 0 SIRT5 inhibits TRIM21 activity by deacetylation +SOX9 SOX9 DNA-binding; Transcription factor P48434 374148 chicken S181-p 456981 YQPRRRKsVKNGQSE sumoylation signaling pathway regulation 23382206 12 2 0 induce NCC delamination +CACNA1C CACNA1C Channel, calcium; Membrane protein, integral; Membrane protein, multi-pass BAA34185.2 guinea pig S1626-p 10349704 KKIWKRTsMKLLDQV Ca_chan_IQ activity, induced; molecular association, regulation; protein conformation Calmodulin(DISRUPTS) 30042022 3 0 0 +CLIP1 Restin iso3 Cytoskeletal P30622-2 6249 12q24.31 human S1318-p 3189736 DDLNNYDsDDQEKQS protein stabilization; intracellular localization cell cycle regulation; carcinogenesis, induced; apoptosis, inhibited; transcription, altered 23661607 3 17 0 induce AR stabilization and nuclear translocation/accumulation +Kcnq2 Kv7.2 Channel, potassium; Membrane protein, integral; Membrane protein, multi-pass O88943 170848 3q43 rat S534-p 11082900 CVMRFLVsKRKFKES KCNQ_channel activity, induced 12754513 1 0 0 Mutants showed reduced currents induced by acetylcholine. +PGM1 PGM1 Carbohydrate Metabolism - amino sugar and nucleotide sugar; Carbohydrate Metabolism - galactose; Carbohydrate Metabolism - glycolysis and gluconeogenesis; Carbohydrate Metabolism - pentose phosphate pathway; Carbohydrate Metabolism - starch and sucrose; EC 5.4.2.2; Isomerase P36871 5236 1p31.3 human T467-p 454029 SANDKVYtVEKADNF enzymatic activity, induced 15378030 1 0 0 +Runx1 AML1 DNA-binding; Oncoprotein; Transcription factor Q03347 12394 16 C4|16 53.7 cM mouse Y386-p 51211404 YGASAGSyQFSMVGG RunxI activity, induced; protein stabilization transcription, induced HDAC1(DISRUPTS) DNA(INDUCES) 26598521 1 0 0 +RET Ret EC 2.7.10.1; KINASE; Kinase, protein; Membrane protein, integral; Oncoprotein; Protein kinase, TK; Protein kinase, tyrosine (receptor) P07949 5979 10q11.21 human Y826-p 449893 SRKVGPGyLGSGGSR PK_Tyr_Ser-Thr enzymatic activity, induced 28009299 3 2 15 +Tp53 p53 Activator; DNA-binding; Motility/polarity/chemotaxis; Nuclear receptor co-regulator; Transcription factor; Tumor suppressor P02340 22059 11 B3|11 42.83 cM mouse S18-p 447490 ISLELPLsQETFSGL P53_TAD activity, induced; molecular association, regulation; protein stabilization; intracellular localization; protein conformation; phosphorylation cell cycle regulation; carcinogenesis, induced; apoptosis, altered; carcinogenesis, inhibited; cell growth, inhibited; apoptosis, induced; transcription, induced; transcription, altered; DNA repair, induced; apoptosis, inhibited; transcription, inhibited; cell growth, altered 14-3-3 beta(INDUCES); p53(INDUCES); STRAP(INDUCES); NME1(INDUCES); p21Cip1(INDUCES) 10747924; 10781582; 11470783; 12065413; 12186934; 12356735; 12524542; 12857758; 12907610; 12909629; 14729946; 15226436; 15866171; 15975986; 16314418; 16757976; 18089799; 18519674; 18606816; 18769132; 20145032; 20876800; 21887248; 22532570; 25101980; 27568562; 34930892; 35210557; 36516759 480 12 0 +NDUFA10 NDUFA10 EC 1.6.5.3; EC 1.6.99.3; Energy Metabolism - oxidative phosphorylation; Mitochondrial; Oxidoreductase O95299 4705 2q37.3 human S250-p 32001601 KTFLPEMsEKCEVLQ dNK activity, induced 28137779 2 1 0 electron transfer from complex I to ubiquinone +HSPB1 HSP27 Chaperone; Heat shock protein; Motility/polarity/chemotaxis; SUMO LIGASE; SUMO ligase P04792 3315 7q11.23 human S83-p 452224 ALSRQLSsGVSEIRH molecular association, regulation cell differentiation, induced Tau(INDUCES) 31974309; 34581912 3 21 23 +Kcnj1 ROMK Channel, potassium; Membrane protein, integral; Membrane protein, multi-pass O88335 56379 9|9 A4 mouse S25-p 449605 RQRARLVsKDGRCNI IRK activity, induced; intracellular localization 12684516 9 0 0 +Junb JunB Motility/polarity/chemotaxis; Oncoprotein; Transcription factor P09450 16477 8 C3|8 41.41 cM mouse K267-sm 3144822 MEDQERIkVERKRLR bZIP_1 intracellular localization transcription, induced 18424718 1 0 0 +APBB1 Fe65 Adaptor/scaffold; Apoptosis; Transcription regulation O00213 322 11p15.4 human S610-p 2035401 ECRVRFLsFLAVGRD PID molecular association, regulation; intracellular localization; protein conformation APP(DISRUPTS) 26188042 2 0 0 +SQSTM1 SQSTM1 Autophagy; Nuclear receptor co-regulator; Ubiquitin conjugating system Q13501 8878 5q35.3 human K420-ac 1879848302 LTRLLQTkNYDIGAA molecular association, regulation ubiquitin(INDUCES); SQSTM1(DISRUPTS) 31857589 1 1 0 enhances p62 body formation, clearance of poly-Ub proteins +Esrrg ERR3 DNA-binding; Nuclear receptor; Transcription factor P62509 26381 1|1 H5-H6 mouse K360-sm 1725303 VKKYKSMkLEKEEFV Hormone_recep transcription, inhibited 18063693 1 0 0 +GPRC5A RAIG1 GPCR, family 3; Membrane protein, integral; Membrane protein, multi-pass; Receptor, GPCR Q8NFJ5 9052 12p13.1 human Y320-p 455045 GDTLYAPySTHFQLQ cell growth, induced 25311788 1 13 174 Tyrosine phosphorylation inhibits the suppressive effect of RAIG1 on cell invasion and anchorage-independent growth. +ZDHHC13 ZDHHC13 EC 2.3.1.225; Membrane protein, integral; Membrane protein, multi-pass; Transferase Q8IUH4 54503 11p15.1 human S8-p 41455513 MEGPGLGsQCRNHSH molecular association, regulation MC1R(INDUCES) 28869973 1 1 0 +PPP2R5D PPP2R5D Motility/polarity/chemotaxis; PHOSPHATASE; Protein phosphatase, regulatory subunit Q14738 5528 6p21.1 human S573-p 457390 KVLLRRKsELPQDVY enzymatic activity, inhibited 30115685 7 53 347 PP1 inactivates +JUN Jun Oncoprotein; Transcription factor P05412 3725 1p32.1 human K226-sm 2793916 HPRLQALkEEPQTVP Jun intracellular localization transcription, induced; transcription, inhibited 16055710; 19106612 5 2 0 sumoylation of PML is necessary for coactivating transcription with c-Jun; intranuclear distribution +VGLL4 VGLL4 iso4 Transcription, coactivator/corepressor Q14135-4 9686 3p25.3-p25.2 human S58-p 478547 RTGPPPIsPSKRKFS VGLL4 cell cycle regulation; cell growth, induced 28739871 1 27 40 Mitotic phosphorylation +CNOT7 CNOT7 EC 3.1.13.4; Transcription, coactivator/corepressor Q9UIV1 29883 8p22 human K200-ac 59117701 YDVKYLMkSCKNLKG CAF1 molecular association, regulation cell differentiation, inhibited; RNA stability, inhibited RNA(INDUCES) 27635759 1 1 0 +MYH10 MYH10 Motility/polarity/chemotaxis; Motor P35580 4628 17p13.1 human S1956-p 465600 EGASLELsDDDTESK molecular association, regulation; intracellular localization cytoskeletal reorganization MYH10(INDUCES); ACTA1(INDUCES) 25869664; 30087119; 30655296 4 74 5 +Abl2 Arg EC 2.7.10.2; KINASE; Kinase, protein; Oncoprotein; Protein kinase, TK; Protein kinase, tyrosine (non-receptor) Q4JIM5 11352 1 G3|1 67.71 cM mouse Y439-p 447923 RLMTGDTyTAHAGAK PK_Tyr_Ser-Thr enzymatic activity, induced 12748290 4 39 1640 +CALD1 Caldesmon Actin-binding NP_776683 281660 cow S531-p 448466 QSVDKVTsPTKV___ molecular association, regulation; intracellular localization cytoskeletal reorganization MYH1(DISRUPTS) 12788788; 15521070 19 19 0 +Aatk Lmr1 EC 2.7.11.1; KINASE; Kinase, protein; Membrane protein, integral; Protein kinase, Ser/Thr (non-receptor); Protein kinase, TK; Protein kinase, tyrosine (receptor) Q80YE4 11302 11|11 E2 mouse S528-p 456513 VPVLSAHsPSVGSEY apoptosis, induced 16100393 1 0 0 +Atp2a2 SERCA2 Cell adhesion; EC 3.6.3.8; Endoplasmic reticulum; Hydrolase; Membrane protein, integral; Membrane protein, multi-pass; Transporter; Transporter, ion channel P11507 29693 12q16 rat S38-p 448740 KLKERWGsNELPAEE Cation_ATPase_N activity, induced 7929371 1 6 0 Phosphorylation by CaM kinase increased the Vmax for Ca++ transport. +UBE3A UBE3A iso2 EC 6.3.2.-; EC 6.3.2.19; Ligase; Nuclear receptor co-regulator; Transcription, coactivator/corepressor; UBIQUITIN LIGASE; Ubiquitin conjugating system; Ubiquitin ligase Q05086-2 7337 15q11.2 human T485-p 48891100 MYSERRItVLYSLVQ protein stabilization; molecular association, regulation; intracellular localization; enzymatic activity, inhibited cytoskeletal reorganization; transcription, altered RAD23A(DISRUPTS); 14-3-3 gamma(INDUCES) 26255772; 28559284; 28835500 3 1 0 +DIXDC1 DIXDC1 iso2 Cell adhesion; Cell development/differentiation Q155Q3-2 85458 11q23.1 human S381-p 23099075 SKLPHSQsSPTVSST cytoskeletal reorganization 27829159 1 2 2 regulates microtubule network, dendritic spine growth +MAPK7 ERK5 EC 2.7.11.24; KINASE; Kinase, protein; Protein kinase, CMGC; Protein kinase, Ser/Thr (non-receptor) Q13164 5598 17p11.2 human S731-p 455519 DPLPPVFsGTPKGSG intracellular localization; enzymatic activity, inhibited; phosphorylation; enzymatic activity, induced cell growth, induced; apoptosis, inhibited; transcription, induced; transcription, altered 20667468; 30132833; 31201162 5 11 0 MYCN protein; in DIPG cells +Tsc2 TSC2 Cell cycle regulation; GAP; GAP, misc.; Nuclear receptor co-regulator; Tumor suppressor P49816 24855 10q12 rat S1377-p 469993 ARPTVDLsFQPSQPL activity, inhibited; phosphorylation translation, altered; apoptosis, inhibited 16959574 1 1 8 inhibits mTOR signaling. required for Wnt-3a to stimulation phosphorylation of S6K and 4EBP1 and increase protein levels of cyclin D1 and VEGF (cyclin D1 through translation not transcription). +ECT2 ECT2 GEF; GEF, Rac/Rho; Motility/polarity/chemotaxis Q9H8V3 1894 3q26.31 human T373-p 456870 VSMLSLNtPNSNRKR activity, induced; protein conformation 16170345 3 14 4 +PTEN PTEN Carbohydrate Metabolism - inositol phosphate; EC 3.1.3.16; EC 3.1.3.48; EC 3.1.3.67; Motility/polarity/chemotaxis; Nuclear receptor co-regulator; PHOSPHATASE; Phosphatase, lipid; Tumor suppressor P60484 5728 10q23.31 human K13-ub 27490407 KEIVSRNkRRYQEDG intracellular localization apoptosis, induced; exocytosis, induced 23012657; 23637190 6 0 0 inhibition of PTEN nuclear translocation protects against ischemic-neuronal injuries; Ndfip regulates of the exosomal export of PTEN, +TPM3 TPM3 Actin-binding; Contractile; Cytoskeletal; Motility/polarity/chemotaxis; Motor; Oncoprotein P06753 7170 1q21.3 human S284-p 484088 HALNDMTsI______ Tropomyosin cytoskeletal reorganization 32977471 1 12 75 +PCNT PCNT Cell cycle regulation O95613 5116 21q22.3 human S1241-p 25617501 ISSHMREsFLMSPES cytoskeletal reorganization 22184200; 24466316 2 0 0 important for spindle formation and centrosomal microtubule nucleation and the recruitment of the PCM proteins for centrosome maturation in mitosis; centrosome maturation and bipolar spindle formation during mitosis +TRIM28 TIF1B EC 6.3.2.-; KINASE; Kinase, protein; Ligase; Nuclear receptor co-regulator; Protein kinase, atypical; SUMO LIGASE; SUMO ligase; Transcription, coactivator/corepressor; UBIQUITIN LIGASE; Ubiquitin conjugating system; Ubiquitin ligase Q13263 10155 19q13.43 human K779-sm 2798309 FNKLTEDkADVQSII molecular association, regulation; acetylation; methylation cell growth, induced; transcription, inhibited CHD-3(INDUCES) 17079232; 17942393; 21642969; 31391303 6 8 0 loss of TF1B sumoylation induces dsRNA-activated IFN-mediated defenses that rely on RIG-I, MAVS, TBK1, and JAK1 transcription, SUMOylated TIF1B Is required to support efficient virus replication +MED28 MED28 Transcription factor Q9H204 80306 4p15.32 human Y64-p 466940 ASLVSQDyVNGTDQE Med28 molecular association, regulation GRB2(INDUCES) 16899217 1 0 0 +Cry2 CRY2 DNA-binding; Lyase Q9R194 12953 2|2 E1 mouse S553-p 456804 TGPRALSsGPASPKR protein degradation 15980066; 20123978 2 1 0 required for the circadian time-keeping mechanism +Fto FTO DEMETHYLASE; Demethylase; EC 1.14.11.- Q8BGW1 26383 8 C4-C5|8 44.34 cM mouse S249-p 1115398000 YSYSCEGsEDESEDE FTO_NTD protein degradation; ubiquitination 29777057 1 1 0 +PRKCH PKCH EC 2.7.11.13; KINASE; Kinase, protein; Protein kinase, AGC; Protein kinase, Ser/Thr (non-receptor) P24723 5583 14q23.1 human T656-p 3914109 IKEEPVLtPIDEGHL Pkinase_C protein stabilization; enzymatic activity, induced DNA repair, induced; cell motility, induced; cell growth, induced; apoptosis, inhibited 34593629 2 10 8 +Irs1 IRS1 Adaptor/scaffold; Motility/polarity/chemotaxis P35569 16367 1 C5|1 42.0 cM mouse Y891-p 447556 EPKSPGEyVNIEFGS signaling pathway regulation 20332342 13 2 0 Rictor/mTORC2 signaling in energy metabolism in fat cells +Myo3b MYO3B Actin-binding; EC 2.7.11.1; KINASE; Kinase, protein; Motor; Protein kinase, STE; Protein kinase, Ser/Thr (non-receptor) Q1EG27 329421 2|2 C2 mouse T1246-p 36841909 YYNQLNGtLEYQGSQ enzymatic activity, induced 21895655 1 1 0 +IRS1 IRS1 Adaptor/scaffold; Motility/polarity/chemotaxis P35568 3667 2q36.3 human S794-p 447557 QHLRLSTsSGRLLYA molecular association, regulation; phosphorylation apoptosis, induced; signaling pathway regulation; cell growth, altered PIK3C2A(DISRUPTS); PIK3R1(DISRUPTS) 17459875; 20363874 10 0 0 decreases IRS1-tyrosine phosphorylation, decreases protein synthesis, inhibits Akt/TSC2/p70S6K signaling pathway +FOXC2 FOXC2 Apoptosis; Cell development/differentiation; DNA-binding; Transcription factor Q99958 2303 16q24.1 human S367-p 28129600 DHPSGPTsPLSALNL molecular association, regulation cell motility, induced; transcription, induced; transcription, altered DNA(INDUCES) 23878394; 27292262 3 1 0 confer combined EMT and stem cell attributes in vitro, promotes metastasis, directly regulates ZEB1 expression; implicated in vascular remodeling in vivo +NOXA1 NOXA1 Activator Q86UR1 10811 9q34.3 human S461-p 990301 VPAGPRMsGAPGRLP molecular association, regulation; intracellular localization; enzymatic activity, inhibited 14-3-3 zeta(INDUCES) 17913709 2 0 0 regulates association with 14-3-3 and dissociation from Nox1, which in-turn inhibits Nox1 activity and production of ROS +EPN1 epsin 1 Motility/polarity/chemotaxis; Vesicle Q9Y6I3 29924 19q13.42 human S382-p 3178200 FSDPWGGsPAKPSTN molecular association, regulation AP2A1(DISRUPTS); REPS2(DISRUPTS) 10764745 1 0 0 Phosphorylation inhibits binding during mitosis. S357D mutation lost effect of insulin-dependent endocytosis.; Phosphorylation inhibits during mitosis +NUP62 NUP62 Adaptor/scaffold; Nucleoporin P37198 23636 19q13.33 human Y422-p 463925 KEQSGTIyLQHADEE Nsp1_C intracellular localization 25349423 1 0 5 +FUS hnRNP P2 DNA-binding; Nuclear receptor co-regulator; Oncoprotein; RNA splicing; RNA-binding; SUMO LIGASE P35637 2521 16p11.2 human S346-p 14160213 VSFDDPPsAKAAIDW RRM_1 molecular association, regulation hnRNP P2(DISRUPTS) 35753345 1 6 0 +SHC1 SHC1 Adaptor/scaffold; Apoptosis; Mitochondrial; Motility/polarity/chemotaxis P29353 6464 1q21.3 human Y427-p 448511 ELFDDPSyVNVQNLD molecular association, regulation apoptosis, altered; cell motility, altered; cell growth, altered GRB2(INDUCES); GRB2(NOT_REPORTED); PPP2CA(DISRUPTS) 11884620; 15688026; 7731718; 8084588; 8947042; 9083103 42 91 1971 +Hspb1 HSP27 Chaperone; Heat shock protein; Motility/polarity/chemotaxis; SUMO LIGASE; SUMO ligase P14602 15507 5 G2|5 75.51 cM mouse S86-p 448403 RALNRQLsSGVSEIR activity, induced; intracellular localization apoptosis, inhibited 15731106 78 104 289 +VAV1 VAV1 GEF; GEF, Rac/Rho; Motility/polarity/chemotaxis; Oncoprotein P15498 7409 19p13.3 human Y836-p 14652800 VGWFPANyVEEDYSE carcinogenesis, altered; cell growth, altered 20457609 2 1 0 +H2BC3 H2B DNA-binding P33778 3018 6p22.2 human S112-gl 22267603 ELAKHAVsEGTKAVT intracellular localization transcription, induced 35690146 2 1 0 Dot1L is recruited OGT to chromatin to enhance histone H2B S112 O-GlcNAc and increases H2B K120 ubiquitination +FANCD2 FANCD2 DNA repair, damage Q9BXW9 2177 3p25.3 human S178-p 482181 NIPRLIVsQLKWLDR FancD2 activity, induced; molecular association, regulation; ubiquitination; intracellular localization signaling pathway regulation DNA(INDUCES) 37392383 1 2 0 regulates the FA pathway +Musk MUSK EC 2.7.10.1; KINASE; Kinase, protein; Membrane protein, integral; Protein kinase, TK; Protein kinase, tyrosine (receptor) Q62838 rat Y750-p 3146801 FGLSRNIySADYYKA PK_Tyr_Ser-Thr phosphorylation; enzymatic activity, induced 10619845 1 3 0 promotes MuSK phosphorylation; promotes AChRb clustering and phosphorylation +JUN Jun Oncoprotein; Transcription factor P05412 3725 1p32.1 human T8-p 17737604 MTAKMETtFYDDALN Jun carcinogenesis, altered; cell growth, altered 21177766 1 0 0 +FLII FLI Actin-binding; Nuclear receptor co-regulator Q13045 2314 17p11.2 human S436-p 470489 RLRRRKDsAQDDQAK molecular association, regulation carcinogenesis, induced; autophagy, inhibited; transcription, induced KHDRBS1(INDUCES) 19293151; 29898994 3 28 255 may induce transcription of the estrogen receptor; formation of aggregates +SAT1 SAT ACETYLTRANSFERASE; Acetyltransferase; Amino Acid Metabolism - arginine and proline; EC 2.3.1.57 P21673 6303 Xp22.11 human K87-ub 486249 TYDPWIGkLLYLEDF Acetyltransf_1 protein degradation 11485561 1 0 0 +FOXA1 FOXA1 DNA-binding; Transcription factor P55317 3169 14q21.1 human Y464-p 60189901 PAYYQGVySRPVLNT transcription, induced 27883218 1 0 0 +PDGFRA PDGFRA EC 2.7.10.1; KINASE; Kinase, protein; Membrane protein, integral; Oncoprotein; Protein kinase, TK; Protein kinase, tyrosine (receptor) P16234 5156 4q12 human Y988-p 450905 RVDSDNAyIGVTYKN molecular association, regulation PLCG1(INDUCES) 7535778 3 6 19 +Psma6 PSMA6 EC 3.4.25.1; Protease; Proteasome complex Q9QUM9 26443 12|12 C1 mouse K104-ac 475743 EAANWKYkYGYEIPV Proteasome protein degradation 24037710 0 7 27 +Pdpk1 PDK1 EC 2.7.11.1; KINASE; Kinase, protein; Nuclear receptor co-regulator; Protein kinase, AGC; Protein kinase, Ser/Thr (non-receptor) Q9Z2A0 18607 17|17 A3.3 mouse K299-sm 1876391104 LIFQKIIkLEYHFPE Pkinase phosphorylation; enzymatic activity, induced cell growth, induced; signaling pathway regulation 35210408 1 0 0 induces autophosphorylation of itself and mTOR signaling +IRF1 IRF1 Transcription factor; Tumor suppressor P10914 3659 5q31.1 human K299-sm 2134717 QRVFTDLkNMDATWL protein stabilization; ubiquitination carcinogenesis, induced; apoptosis, inhibited; transcription, inhibited 17942705 1 0 0 inhibits ubiquitination +SARM1 SARM1 Q6SZW1 23098 17q11.2 human S548-p 4739912 AAREMLHsPLPCTGG enzymatic activity, induced 30333228 3 9 3 inhibits mitochondrial respiration +FXYD1 PLM Cell surface; Channel, misc.; Membrane protein, integral O00168 5348 19q13.12 human S83-p 451424 EEGTFRSsIRRLSTR activity, induced; molecular association, regulation; enzymatic activity, induced ATP1A1(DISRUPTS); PLM(INDUCES) 21220422; 21653224; 26429909 22 20 60 enhances PLM oligomerization and modulates its interaction with Na/K-ATPase (NKA); reverse PLM bindiing inhibition of Na,K-ATPase activity ; induces Na+K+ATPase activity +KARS1 KARS Aminoacyl-tRNA synthetase; EC 6.1.1.6; Ligase; Mitochondrial; Translation; Translation regulation Q15046 3735 16q23.1 human T52-p 25692907 EKQLSQAtAAATNHT molecular association, regulation; intracellular localization cell motility, induced EPRS(DISRUPTS) 22751010; 30188867 2 1 0 increase the membrane level of 67LR +GTF2I GTF2I DNA-binding; Transcription, coactivator/corepressor P78347 2969 7q11.23 human Y249-p 459606 ESEDPDYyQYNIQAG activity, induced; intracellular localization transcription, induced; transcription, altered 15664986; 16738337; 20568114; 9837922 5 1 1 +Cacna1b CACNA1B Channel, calcium; Membrane protein, integral; Membrane protein, multi-pass Q02294 257648 3p13 rat S1757-p 465548 FEMLKHMsPPLGLGK GPHH activity, induced 16704976; 19167461 2 0 0 +Gria1 GluR1 Channel, calcium; Channel, ligand-gated; Membrane protein, integral; Membrane protein, multi-pass P23818 14799 11 B1.3|11 34.51 cM mouse S836-p 467226 CYKSRSEsKRMKGFC intracellular localization 19004011 6 0 0 +Atp2a2 SERCA2 Cell adhesion; EC 3.6.3.8; Endoplasmic reticulum; Hydrolase; Membrane protein, integral; Membrane protein, multi-pass; Transporter; Transporter, ion channel O55143 11938 5 62.38 cM|5 F mouse K492-ac 1878093100 LEFSRDRkSMSVYCT enzymatic activity, inhibited 30786847 1 1 0 regulation of ATPase activity, binding of ATP to SERCA2a +RTCB RTCB EC 6.5.1.3 Q9Y3I0 51493 22q12.3 human Y316-p 1876333508 GMAAAGNyAWVNRSS RtcB RNA splicing, inhibited 35193953 1 1 0 +NFE2 NF-E2 Cytoskeletal; DNA-binding; Transcription factor Q16621 4778 12q13.13 human K368-ub 11489907 FLVPRGTkMEATD__ protein degradation; ubiquitination transcription, inhibited 19966288 1 0 0 +Mecp2 MECP2 Transcription, coactivator/corepressor Q9Z2D6 17257 X A7.3|X 37.63 cM mouse S424-p 3191614 PRGGSLEsDGCPKEP molecular association, regulation transcription, inhibited DNA(DISRUPTS) 21765426 1 6 0 +Dync1i2 DYNC1I2 Microtubule-binding; Motility/polarity/chemotaxis; Motor Q62871 116659 3q22 rat S89-p 3195347 VPPPMSPsSKSVSTP molecular association, regulation; intracellular localization endocytosis, induced; cell motility, induced PXN(DISRUPTS); FAK(DISRUPTS); dynactin 1(DISRUPTS) 22553211 1 7 1 regulates focal adhesion turnover and stability; interaction between paxillin and DYNC1I2 facilitates endocytosis +ULK1 ULK1 Autophagy; EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, Other; Protein kinase, Ser/Thr (non-receptor) O75385 8408 12q24.33 human K162-ac 27850502 NPNSIRVkIADFGFA Pkinase enzymatic activity, induced apoptosis, induced 22539723 2 1 0 serum deprivation induced autophagy +EIF4G1 eIF4G iso8 RNA-binding; Translation; Translation initiation Q04637-8 1981 3q27.1 human S1232-p 449798 EAALPPVsPLKAALS molecular association, regulation Mnk1(INDUCES); eIF3-alpha(DISRUPTS); EIF4B(DISRUPTS); EIF4A1(DISRUPTS) 23263986 6 88 59 controls formation of translation initiation complex +Fzd3 FZD3 GPCR, Fz/Smo family; Membrane protein, integral; Membrane protein, multi-pass; Receptor, GPCR Q61086 14365 14 D1|14 34.09 cM mouse S625-p 18507005 TDHSRHSsSHRLNEQ receptor internalization, inhibited; phosphorylation endocytosis, inhibited 21316586 1 0 0 enhances PCP signaling, regulating c-Jun phosphorylation, and affecting growth cone guidance +WASL N-WASP Adaptor/scaffold; Motility/polarity/chemotaxis O00401 8976 7q31.32 human Y256-p 450253 RETSKVIyDFIEKTG PBD activity, induced; molecular association, regulation; phosphorylation cell adhesion, induced; cytoskeletal reorganization N-WASP(INDUCES) 20146487; 20940394; 21097841; 34369620 9 65 1373 +ATF4 ATF-4 DNA-binding; Transcription factor P18848 468 22q13.1 human T114-p 40420007 TMPDDLLtTLDDTCD protein degradation transcription, inhibited 25795775 1 1 0 +GOT2 GOT2 Amino Acid Metabolism - alanine, aspartate and glutamate; Amino Acid Metabolism - arginine and proline; Amino Acid Metabolism - cysteine and methionine; Amino Acid Metabolism - phenylalanine; Amino Acid Metabolism - phenylalanine, tyrosine and tryptophan biosynthesis; Amino Acid Metabolism - tyrosine; EC 2.6.1.1; EC 2.6.1.7; Mitochondrial; Transferase P00505 2806 16q21 human K159-ac 466485 SRDVFLPkPTWGNHT Aminotran_1_2 molecular association, regulation; phosphorylation carcinogenesis, induced; cell growth, induced; apoptosis, inhibited MDH2(INDUCES) 25755250 1 8 32 induces H3 phosphorylation +SMCR8 SMCR8 Unknown function Q8TEV9 140775 17p11.2 human T796-p 55469600 ASPAGAGtLHALSRY autophagy, induced 27103069 1 0 0 +Dab1 DAB1 iso2 Adaptor/scaffold P97318-2 13131 4 C6|4 47.79 cM mouse S491-p 479422 TPAPRQSsPSKSSAS molecular association, regulation; intracellular localization; phosphorylation signaling pathway regulation SH3KBP1(DISRUPTS) 16529723; 18076569; 23506116 7 0 0 regulates trafficking of reelin receptors and hence Reelin signaling pathway +Rasgrf1 RASGRF1 GEF; GEF, Ras P28818 192213 8q31 rat S71-p 18710203 GLYLLEGsICKRMPS PH protein degradation 21382555 1 1 0 +MAVS MAVS Adaptor/scaffold; Membrane protein, integral Q7Z434 57506 20p13 human S338-gl 1872691001 KPPGAVPsNALTNPA phosphorylation 31461653 1 1 0 positively regulates phosphorylation of S442 (data from MAVS 7A mutant) +PTTG1 Securin Cell cycle regulation; Oncoprotein O95997 9232 5q33.3 human T60-p 1239966004 PPALPKAtRKALGTV Securin molecular association, regulation 30154144 1 0 0 nuclear localization +Gabrg2 GABRG2 iso2 Channel, chloride; Channel, ligand-gated; Membrane protein, integral; Membrane protein, multi-pass; Transporter; Transporter, ion channel P22723-2 14406 11 A5|11 24.8 cM mouse Y403-p 455817 LQERDEEyGYECLDG Neur_chan_memb receptor inactivation, induced; activity, induced; receptor internalization, inhibited neural plasticity 17442679; 23904608; 24068823 7 0 0 potentiated GABA currents; neurogenesis, reduces depressive like behaviors; knockout leads to increease in GABA mediated tonic current, in females only +RECQL4 RECQL4 EC 3.6.4.12; Helicase O94761 9401 8q24.3 human S251-p 25173044 EVSIRVGsPQPSSSG ubiquitination; intracellular localization DNA repair, induced DDB1(INDUCES); MRE11A(INDUCES) 29229926 1 15 0 enhances the helicase activity; DNA end resection and HR ; promotes its ubiquitination by DDB1-CUL4A E3 ubiquitin ligase; recruitment to DSBs +FBXO43 FBX43 Unknown function Q4G163 286151 8q22.2 human S76-p 12581000 STSSFQDsGYNELKS protein degradation; ubiquitination 15753281 1 0 0 +Asic1 ASIC1 Channel, cation; Membrane protein, integral; Membrane protein, multi-pass; Transporter; Transporter, ion channel P55926 79123 7q36 rat S477-p 449558 QKEAKRSsADKGVAL activity, inhibited apoptosis, altered 16301179 2 0 0 +DAXX DAXX Apoptosis; Nuclear receptor co-regulator; Nucleolus; Transcription, coactivator/corepressor Q9UER7 1616 6p21.32 human S737-p 467726 PEEIIVLsDSD____ sumoylation; molecular association, regulation apoptosis, altered; transcription, altered SUMO1(INDUCES); PML(INDUCES) 21474068 1 20 0 +Klc2 KLC2 Microtubule-binding; Motor O88448 16594 19 A|19 4.25 cM mouse S575-p 452949 SRMKRASsLNFLNKS molecular association, regulation 14-3-3 eta(INDUCES) 11969417 2 75 63 +ACLY ACLY Carbohydrate Metabolism - citrate (TCA) cycle; EC 2.3.3.8; Lyase; Transferase P53396 47 17q21.2 human K546-ub 12107257 QKFYWGHkEILIPVF CoA_binding protein degradation carcinogenesis, inhibited; cell growth, inhibited 27664236 1 6 1 +ARHGDIA RhoGDI alpha Apoptosis; Cell adhesion; Cell development/differentiation; G protein regulator, misc.; Motility/polarity/chemotaxis P52565 396 17q25.3 human S176-p 1876737500 MLARGSYsIKSRFTD Rho_GDI activity, induced; molecular association, regulation; enzymatic activity, induced carcinogenesis, induced; cell motility, induced; signaling pathway regulation 14-3-3 theta(INDUCES) 24820414 1 0 0 14-3-3 theta (aka 14-3-3tau) interaction with RhoGD1 alpha is necessary for the release and activation of RhoA, Rac1 and Cdc42 +Abcc9 ABCC9 Channel, potassium; Membrane protein, integral; Membrane protein, multi-pass; Transporter; Transporter, ABC family P70170 20928 6 G2|6 74.35 cM mouse S1387-p 483973 HTLRSRLsIILQDPI ABC_tran activity, induced; protein conformation 17596331; 18198173 2 0 0 Molecular modeling shows phosphorylated S1387 interacts with Y506 and R1462 leading to channel activation. +Ikbkg IKKG Adaptor/scaffold; Protein kinase, regulatory subunit O88522 16151 X|X A7.3 mouse K302-sm 2255103 KAQADIYkADFQAER CC2-LZ phosphorylation signaling pathway regulation 26596471 5 0 0 induces p65 phosphorylation, induces IKK/NF-KB signaling +PAG1 PAG Adaptor/scaffold; Membrane protein, integral Q9NWQ8 55824 8q21.13 human Y181-p 454746 NMVEDCLyETVKEIK PAG molecular association, regulation RASA1(INDUCES) 17389760 2 22 115 +XRCC1 XRCC1 DNA repair, damage P18887 7515 19q13.31 human S418-p 3181471 EEDEASHsGGSGDEA molecular association, regulation PARP1(DISRUPTS) 25477519 1 3 1 +MAPT Tau iso8 ACETYLTRANSFERASE; Acetyltransferase; Cytoskeletal P10636-8 4137 17q21.31 human S198-p 449551 SGDRSGYsSPGSPGT molecular association, regulation WWOX(INDUCES); Tau(INDUCES) 15126504; 16923168 21 15 10 enhances tau aggregation; binding increased by estradiol +Spred1 SPRED1 Inhibitor Q924S8 114715 2|2 E5 mouse Y377-p 18899303 LCAESMLyHCMSDSE Sprouty cell differentiation, altered; signaling pathway regulation 21531714 1 0 0 inhibits the Ras/ERK pathway +Tp63 p63 DNA-binding; Transcription factor O88898 22061 16 B1|16 17.37 cM mouse S160-p 451600 SSTFDALsPSPAIPS apoptosis, induced; signaling pathway regulation 29988075 6 2 0 +Notch1 Notch 1 Membrane protein, integral; Motility/polarity/chemotaxis; Oncoprotein; Receptor, misc.; Transcription factor Q01705 18128 2 A3|2 18.91 cM mouse T2487-p 483083 VPEHPFLtPSPESPD protein degradation; molecular association, regulation; ubiquitination FBXW7(INDUCES) 17646409 5 1 0 +ERBB4 HER4 EC 2.7.10.1; KINASE; Kinase, protein; Membrane protein, integral; Protein kinase, TK; Protein kinase, tyrosine (receptor) Q15303 2066 2q34 human Y1035-p 4825102 FNIPPPIyTSRARID molecular association, regulation STAT1(INDUCES) 18721752 0 1 0 +NFKBIA IkB-alpha DNA-binding; Inhibitor P25963 4792 14q13.2 human S36-p 448204 RHDSGLDsMKDEEYE protein degradation; protein stabilization; molecular association, regulation; phosphorylation; activity, induced; sumoylation; ubiquitination; intracellular localization apoptosis, altered; cell growth, induced; apoptosis, induced; apoptosis, inhibited; transcription, induced; transcription, altered IkB-beta(INDUCES) 10754328; 11502888; 11752211; 12068083; 12085227; 12419817; 12432072; 12527907; 14523047; 15843586; 16007147; 16163708; 16735506; 20696840; 28467781; 33876201; 34558646; 7739562; 7796813; 7878466; 8649784; 8657102; 9252186; 9351830; 9724653; 9734360 99 2 6 +PTPRCAP PTPRCAP Cell surface; Membrane protein, integral Q14761 5790 11q13.2 human S153-p 23136094 RAEEARDsDTEGDLV PTPRCAP protein stabilization 30482149 3 2 1 +DEPTOR DEPTOR Apoptosis Q8TB45 64798 8q24.12 human T295-p 4723863 GYFSSSPtLSSSPPV protein degradation; molecular association, regulation BTRC(INDUCES) 22017875 2 4 0 +Inpp5d SHIP EC 3.1.3.86; Motility/polarity/chemotaxis; Phosphatase, lipid Q9ES52 16331 1 D|1 44.44 cM mouse S441-p 15621804 QGKTRDDsADYIPHD Exo_endo_phos enzymatic activity, induced 20810657 1 1 0 +VRK1 VRK1 EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, CK1; Protein kinase, Ser/Thr (non-receptor) Q99986 7443 14q32.2 human T386-p 1868585000 QTEEAIQtRSRTRKR phosphorylation 32266931 1 1 0 induces phosphorylation of c-Jun and p53 +RPS6KA3 RSK2 EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, AGC; Protein kinase, Ser/Thr (non-receptor) P51812 6197 Xp22.12 human Y529-p 464205 TITKTVEyLHAQGVV Pkinase molecular association, regulation apoptosis, altered; cell motility, induced; cell growth, induced ERK2(INDUCES); ERK1(INDUCES); FGFR3(INDUCES) 17785202; 18156174; 25014166 4 1 4 +LRP2 LRP2 Membrane protein, integral; Motility/polarity/chemotaxis; Receptor, misc. P98164 4036 2q31.1 human S4587-p 767905 WNLFKRKsKQTTNFE receptor internalization, altered; receptor recycling, altered 17555532 1 0 0 +RPS6KB1 p70S6K EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, AGC; Protein kinase, Ser/Thr (non-receptor); Translation P23443 6198 17q23.1 human S394-p 448806 TRQTPVDsPDDSTLS Pkinase_C activity, induced; protein conformation; enzymatic activity, induced 11914378; 17446865; 9271440 17 4 11 +PLCG2 PLCG2 Carbohydrate Metabolism - inositol phosphate; EC 3.1.4.11; Motility/polarity/chemotaxis; Phospholipase P16885 5336 16q23.3 human Y759-p 447941 LYDVSRMyVDPSEIN molecular association, regulation; enzymatic activity, induced LYN(INDUCES) 12780340; 15184383; 30344948; 32184360; 34607960 21 13 227 +PTEN PTEN Carbohydrate Metabolism - inositol phosphate; EC 3.1.3.16; EC 3.1.3.48; EC 3.1.3.67; Motility/polarity/chemotaxis; Nuclear receptor co-regulator; PHOSPHATASE; Phosphatase, lipid; Tumor suppressor P60484 5728 10q23.31 human T366-p 449634 ASSSTSVtPDVSDNE molecular association, regulation; intracellular localization; activity, inhibited RAD52(INDUCES) 16107342; 24047694 7 4 0 facilitates translocation to chromatin and interaction with RAD52 +Adam22 ADAM22 Cell adhesion; Membrane protein, integral; Motility/polarity/chemotaxis Q9R1V6 11496 5 A1|5 3.39 cM mouse S855-p 469109 RFRPRSNsTETLSPA protein stabilization; molecular association, regulation endocytosis, inhibited 14-3-3 epsilon(INDUCES) 34910912 2 15 74 +MAP4 MAP4 Cytoskeletal; Motility/polarity/chemotaxis P27816 4134 3p21.31 human K1028-ac 36298043 GNVQIQNkKVDISKV Tubulin-binding cytoskeletal reorganization 28002468 1 2 0 +NOTCH1 Notch 1 Membrane protein, integral; Motility/polarity/chemotaxis; Oncoprotein; Receptor, misc.; Transcription factor P46531 4851 9q34.3 human K2174-ac 18899510 ACGSKEAkDLKARRK intracellular localization cell growth, induced; apoptosis, inhibited 28377411 2 1 0 +STAT5A STAT5A DNA-binding; Motility/polarity/chemotaxis; Oncoprotein; Transcription factor P42231 443419 sheep T757-p 447766 GEFDLDEtMDVARHV intracellular localization transcription, inhibited 11133982 3 0 0 +Gabbr1 GABBR1 GPCR, family 3; Membrane protein, integral; Membrane protein, multi-pass; Receptor, GPCR Q9Z0U4 81657 20p12 rat K991-ub 59175202 SRVHLLYk_______ receptor recycling, inhibited; protein degradation; intracellular localization 27573246 1 0 0 +Camk2a CAMK2A EC 2.7.11.17; KINASE; Kinase, protein; Protein kinase, CAMK; Protein kinase, Ser/Thr (non-receptor) P11275 25400 18q12.1 rat T306-p 449596 LKGAILTtMLATRNF molecular association, regulation; enzymatic activity, inhibited cytoskeletal reorganization Calmodulin(DISRUPTS) 1324926; 20660727; 2162839 18 10 2 regulate synaptic strength +ADD2 ADD2 Cytoskeletal; Motility/polarity/chemotaxis P35612 119 2p13.3 human S600-p 481589 PAKSAPAsPVQSPAK cell growth, induced; cytoskeletal reorganization 21606488 3 28 1 +SOX10 SOX10 Cell development/differentiation; DNA-binding; Transcription factor P56693 6663 22q13.1 human K357-sm 3875805 VDAKAQVkTETAGPQ molecular association, regulation transcription, inhibited EGR2(DISRUPTS); PAX3(DISRUPTS) 16494873 2 0 0 +PELI1 PELI1 Adaptor/scaffold; EC 6.3.2.-; EC 6.3.2.19; Ligase; UBIQUITIN LIGASE; Ubiquitin conjugating system; Ubiquitin ligase Q96FA3 57162 2p14 human T86-p 7388011 YTLSRAQtVVVEYTH Pellino ubiquitination; enzymatic activity, induced 19264966 2 0 0 +RANGAP1 RANGAP1 GAP; GAP, Ras P46060 5905 22q13.2 human S504-p 1873645604 LMQKAFNsSSFNSNT RanGAP1_C sumoylation; intracellular localization 34110283 1 0 0 WT RANGAP1 rescues nuclear import of NF-ATc1, NF-kB, AP-1 in RanGAP1 (KD), required in various nuclear transport pathways +TRPM8 TRPM8 Channel, cation; Membrane protein, integral; Membrane protein, multi-pass Q7Z2W7 79054 2q37.1 human S9-p 12570903 SFRAARLsMRNRRND activity, induced 20110357 1 0 0 +TGFBR2 TGFBR2 EC 2.7.11.30; KINASE; Kinase, protein; Membrane protein, integral; Oncoprotein; Protein kinase, Ser/Thr (receptor); Protein kinase, TKL P37173 7048 3p24.1 human S409-p 452048 LRLDPTLsVDDLANS PK_Tyr_Ser-Thr enzymatic activity, induced 9155023 1 5 0 +HDAC5 HDAC5 DEACETYLASE; Deacetylase; EC 3.5.1.98; Hydrolase Q9UQL6 10014 17q21.31 human S1108-p 17542307 AAAAREHsPRPAEEP molecular association, regulation; intracellular localization GPS2(INDUCES); SMRT(INDUCES); HDAC3(INDUCES); N-CoR1(INDUCES); TBL1X(INDUCES); TBL1XR1(INDUCES) 24920159 2 10 15 interactions have been defined by quantitative mass spectrometry +EGLN2 EGLN2 EC 1.14.11.29; Oxidoreductase Q96KS0 112398 19q13.2 human S401-p 62873403 KGVQVPVsQPPTPT_ protein degradation; molecular association, regulation; ubiquitination FBXW7(INDUCES) 28036276 1 1 0 +Srebf1 SREBP-1 iso1 DNA-binding; Membrane protein, integral; Membrane protein, multi-pass; Transcription factor P56720-1 78968 10q22 rat S422-p 4785186 RGSSSGGsDSEPDSP protein stabilization; molecular association, regulation; intracellular localization transcription, induced SCAP(INDUCES) 31541353 1 5 0 activates genes involved in de novo lipogenesis +CD36 CD36 Cell adhesion; Membrane protein, integral; Membrane protein, multi-pass P16671 948 7q21.11 human T92-p 23017300 VKQRGPYtYRVRFLA CD36 molecular association, regulation signaling pathway regulation THBS1(DISRUPTS) 22247259 1 1 0 +Sirt7 SIRT7 DEACETYLASE; Deacetylase; EC 3.5.1.-; Nucleolus Q8BKJ9 209011 11|11 E2 mouse S137-p 1871979201 LQKGRPVsAADLSEA SIR2 protein stabilization; acetylation; ubiquitination; intracellular localization; enzymatic activity, induced transcription, induced 33495326 1 1 0 causes deacetylation and relocation of NPM and as a result inhibition of p53 ubiquitination and degradation of p53 +INSR INSR EC 2.7.10.1; KINASE; Kinase, protein; Membrane protein, integral; Protein kinase, TK; Protein kinase, tyrosine (receptor) P06213 3643 19p13.2 human S1221-p 3103703 TTSSDMWsFGVVLWE PK_Tyr_Ser-Thr enzymatic activity, induced 10866039 1 0 0 +IDH2 IDH2 Carbohydrate Metabolism - citrate (TCA) cycle; EC 1.1.1.42; Mitochondrial; Other Amino Acids Metabolism - glutathione; Oxidoreductase P48735 3418 15q26.1 human K413-ac 1204122 VESGAMTkDLAGCIH Iso_dh molecular association, regulation; enzymatic activity, inhibited carcinogenesis, induced; cell growth, induced IDH2(DISRUPTS) 26631723; 28536275; 32457458; 34289383 6 3 5 inhibits substrate (alpha -KG) and co-factor (NADPH) binding: 2-HG for transformation and but not high levels for cytotoxicity ; alters mitochondrial metabolism- increases cellular ROS and glycolysis, decreases IDH2 dimerization +TP53 p53 Activator; DNA-binding; Motility/polarity/chemotaxis; Nuclear receptor co-regulator; Transcription factor; Tumor suppressor P04637 7157 17p13.1 human S371-p 447533 AHSSHLKsKKGQSTS activity, induced; molecular association, regulation DNA(INDUCES) 9315650; 9571186 4 0 0 mutation of S371 showed a small decrease in PKC-mediated activation, but did not abolish the PKC effect +GTF2IRD1 GTF2IRD1 DNA-binding Q9UHL9 9569 7q11.23 human K495-sm 27992502 LGGLRPIkIEPEDLD protein degradation; molecular association, regulation PIAS2(INDUCES); ZMYM5(INDUCES) 23145142 1 2 0 +GSK3B GSK3B EC 2.7.11.1; EC 2.7.11.26; KINASE; Kinase, protein; Protein kinase, CMGC; Protein kinase, Ser/Thr (non-receptor) P49841 2932 3q13.33 human K292-sm 4617400 NPNYTEFkFPQIKAH Pkinase protein stabilization; intracellular localization; phosphorylation; enzymatic activity, induced apoptosis, induced 18949077 1 0 0 nuclear localization, SUMOylation of GSK3B is required for s Y216 phosphorylation, and its kinase activity +NDUFV3 NDUFV3 Energy Metabolism - oxidative phosphorylation; Mitochondrial; Oxidoreductase P56181 4731 21q22.3 human S105-p 4751741 QPSSGREsPRH____ activity, induced cell cycle regulation 24746669 1 17 0 increases mitochondrial respiration for G/2M transition +ACTA1 ACTA1 Cell development/differentiation; Contractile; Cytoskeletal; Motility/polarity/chemotaxis P68133 58 1q42.13 human R256-m1 1876986202 VITIGNErFRCPETL Actin intracellular localization transcription, induced 32997990 1 1 0 +TRAF3 TRAF3 UBIQUITIN LIGASE; Ubiquitin conjugating system; Ubiquitin ligase Q13114 7187 14q32.32 human Y446-p 1869973806 SLYSQPFyTGYFGYK ubiquitination 32779804 1 0 0 +RUNX2 AML3 DNA-binding; Transcription factor Q13950 860 6p21.1 human S118-p 460037 AELVRTDsPNFLCSV Runt protein degradation; protein stabilization; molecular association, regulation; activity, inhibited cell differentiation, inhibited; cell differentiation, induced; transcription, inhibited; transcription, altered CBFB(DISRUPTS) DNA(INDUCES) 12231506; 16443755; 22247071; 29988028 4 2 0 regulate maintenance of osteogenesis and abrogation of adipogenesis; phosphorylation of this site inhibits osteoblastic cell differentiation +Ctnnd1 CTNND1 Actin-binding; Adaptor/scaffold; Cell adhesion; G protein regulator, misc.; Motility/polarity/chemotaxis P30999 12388 2 D|2 49.45 cM mouse T916-p 450454 ERGDHNRtLDRSGDL molecular association, regulation cell adhesion, inhibited 26175155 5 26 7 decreased homophilic binding affinity of E-cadherin +IRAK1 IRAK1 EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, Ser/Thr (non-receptor); Protein kinase, TKL P51617 3654 Xq28 human S373-p 23116180 RFAGSSPsQSSMVAR Pkinase enzymatic activity, induced 29208712 0 1 1 +Cnr1 CNR1 GPCR, family 1; Membrane protein, integral; Membrane protein, multi-pass; Receptor, GPCR P47746 12801 4 A5|4 16.28 cM mouse S430-p 999608 LDNSMGDsDCLHKHA receptor desensitization, induced 24719095 3 3 0 +Gprc5b GPRC5B GPCR, family 3; Membrane protein, integral; Membrane protein, multi-pass; Receptor, GPCR Q923Z0 64297 7|7 F2 mouse Y307-p 6158489 LQENPPNyFDTSQPR molecular association, regulation Fyn(INDUCES) 23169819 1 2 11 induces phosphorylation of Cav1 and inflammatory signaling in adipose tissue +PLEKHG1 PLEKHG1 GEF; GEF, Rac/Rho Q9ULL1 57480 6q25.1 human Y559-p 464047 NEDDEDDyQMFVPSF activity, induced; molecular association, regulation; intracellular localization cytoskeletal reorganization Fyn(INDUCES) 35031323 1 0 2 +MAZ MAZ C2H2-type zinc finger protein; RNA-binding; Transcription factor O97600 100008693 rabbit S187-p 449094 ALEKKRKsKGPYICA protein conformation; activity, inhibited transcription, inhibited DNA(DISRUPTS) 12697757 1 0 0 +KLF6 KLF6 C2H2-type zinc finger protein; DNA-binding Q99612 1316 10p15.2 human K209-ac 459204 CHFNGCRkVYTKSSH zf-C2H2 cell growth, inhibited; transcription, induced 16230382 1 1 0 +PKM PKM Carbohydrate Metabolism - glycolysis and gluconeogenesis; Carbohydrate Metabolism - pyruvate; EC 2.7.1.40; KINASE; Kinase, other; Mitochondrial; Nucleotide Metabolism - purine P14618 5315 15q23 human T328-p 481749 GKPVICAtQMLESMI PK protein stabilization; intracellular localization cell growth, induced; apoptosis, inhibited; transcription, induced 29262861; 30297868 2 3 0 nuclear accumulation; HIF-1a target genes and beta-catenin target genes +Ppp1r1a PPP1R1A Inhibitor; Protein phosphatase, regulatory subunit P19103 58977 7q36 rat S67-p 447758 LKSTLSMsPRQRKKM DARPP-32 activity, inhibited; phosphorylation 21447388 12 14 2 induces PLB dephosphorylation +Cadps CADPS Vesicle Q62717 26989 15p15 rat S7-p 7712501 _MLDPSSsEEESDEI activity, induced exocytosis, altered 19460754 1 2 0 +RHOT1 RHOT1 EC 3.6.5.-; G protein; G protein, monomeric; G protein, monomeric, Rho; Hydrolase; Membrane protein, integral; Mitochondrial Q8IXI2 55288 17q11.2 human K572-ub 32005103 PSKDIFVkLTTMAMY protein degradation; intracellular localization autophagy, induced 34152608 2 0 0 induces mitophagy by recruiting Parkin to mitochondria +SCML2 SCML2 Transcription factor Q9UQR0 10389 Xp22.13 human S570-p 478158 MYIHTSVsQDFSRSV protein stabilization; molecular association, regulation DDB1(DISRUPTS) 37353627 1 4 13 +CHD4 CHD-4 DNA-binding; EC 3.6.4.12; Helicase Q14839 1108 12p13.31 human S1349-p 481897 QVNYNDGsQEDRDWQ DUF1087 molecular association, regulation; intracellular localization DNA(NOT_REPORTED) 21219611 1 12 17 required for efficient repair of double strand DNA breaks +E2F1 E2F1 DNA-binding; Transcription factor Q01094 1869 20q11.22 human S332-p 447868 TDSATIVsPPPSSPP molecular association, regulation; intracellular localization; protein conformation cell cycle regulation; transcription, induced; transcription, altered; cell growth, altered PRB1(INDUCES); Rb(DISRUPTS); E4(INDUCES) 20616879; 26724859; 27175585; 8087847 5 0 0 +Tbx2 TBX2 DNA-binding; Transcription factor Q60707 21385 11 C|11 51.34 cM mouse S675-p 1308916 GPSRGALsPSGSAKE activity, induced; protein stabilization; intracellular localization transcription, inhibited 18025091 1 6 0 relocalizes into nuclei after UV radiation +HSP90AB1 HSP90B Chaperone; Heat shock protein P08238 3326 6p21.1 human Y192-p 459272 LKEDQTEyLEERRVK HSP90 protein conformation 23867252 1 7 178 phosphorylation induces altered conformation and governs drug specificity. +LAT LAT Adaptor/scaffold; Membrane protein, integral O43561 27040 16p11.2 human Y156-p 448003 ADEDEDDyHNPGYLV LAT molecular association, regulation PLCG1(INDUCES) 33929486 4 0 1 +Camkk2 CAMKK2 Autophagy; EC 2.7.11.17; KINASE; Kinase, protein; Protein kinase, Other; Protein kinase, Ser/Thr (non-receptor) O88831 83506 12q16 rat T482-p 21336500 KHIPSLAtVILVKTM enzymatic activity, induced 21859090 2 2 0 +PDHA1 PDHA1 Amino Acid Metabolism - valine, leucine and isoleucine biosynthesis; Carbohydrate Metabolism - butanoate; Carbohydrate Metabolism - citrate (TCA) cycle; Carbohydrate Metabolism - glycolysis and gluconeogenesis; Carbohydrate Metabolism - pyruvate; EC 1.2.4.1; Mitochondrial; Oxidoreductase P08559 5160 Xp22.12 human K385-ac 1204112 RGANQWIkFKSVS__ enzymatic activity, inhibited 34518519 1 3 1 metabolic reprogramming associated with renal ?brosis +XRCC6 Ku70 DNA repair, damage; DNA-binding; EC 3.6.4.-; EC 4.2.99.-; Helicase; Nuclear receptor co-regulator; RNA-binding P12956 2547 22q13.2 human K539-ac 458921 PDYNPEGkVTKRKHD Ku_C molecular association, regulation apoptosis, induced BAX(DISRUPTS) DNA(DISRUPTS) 15023334; 17545612 2 2 0 +Ctnnb1 CTNNB1 Actin-binding; Cell adhesion; Motility/polarity/chemotaxis; Nuclear receptor co-regulator; Oncoprotein; Transcription factor Q02248 12387 9 F4|9 72.19 cM mouse S37-p 447582 YLDSGIHsGATTTAP protein degradation; ubiquitination carcinogenesis, inhibited 15308623; 34642308; 9233789 110 3 12 +Ets1 Ets-1 DNA-binding; Motility/polarity/chemotaxis; Oncoprotein; Transcription factor P27577 23871 9 A4|9 17.97 cM mouse S41-p 22650305 VPLLTPSsKEMMSQA protein conformation transcription, induced CBP(INDUCES) 20534573 1 0 0 +Bmal1 BMAL1 DNA-binding; Transcription factor Q9WTL8 11865 7 F1|7 59.17 cM mouse S42-p 25230400 CNRKRKGsATDYQLD molecular association, regulation; methylation transcription, inhibited DNA(DISRUPTS) 35338256 4 3 2 induces H3 methylation +Map3k5 ASK1 EC 2.7.11.25; KINASE; Kinase, protein; Protein kinase, STE; Protein kinase, Ser/Thr (non-receptor) O35099 26408 10|10 A3 mouse S993-p 7449405 SSEYGSVsPDTELKA enzymatic activity, induced 33108364 1 4 0 +PRKDC DNAPK DNA repair, damage; EC 2.7.11.1; KINASE; Kinase, protein; Nucleolus; Protein kinase, Ser/Thr (non-receptor); Protein kinase, atypical P78527 5591 8q11.21 human T2647-p 448713 QQHDFTLtQTADGRS DNAPKcs_CC5 molecular association, regulation; protein conformation; phosphorylation DNA repair, induced; chromatin organization, altered; cell growth, altered SLC25A5(DISRUPTS) DNA(DISRUPTS) 17189255; 22592045; 24687855; 36727301 12 12 8 increases survival in ionizing radiation and repairing double strand DNA breaks; cell survival induced, induces removal of cisplatin adducts from DNA, induces end processing; phosphorylates Artemis +ATXN3 ataxin-3 DEUBIQUITINASE; DNA repair, damage; EC 3.4.19.12; Protease; Transcription regulation; Ubiquitin-specific protease P54252 4287 14q32.12 human S335-p 9441001 SDLGDAMsEEDMLQA UIM activity, induced; protein stabilization; intracellular localization transcription, altered 19542537 1 0 0 +CDCA5 CDCA5 Cell cycle regulation Q96FF9 113130 11q13.1 human S209-p 3208965 DMTLPGIsPPPEKQK Sororin molecular association, regulation cell cycle regulation; carcinogenesis, altered; cell growth, altered H2A.1(DISRUPTS); SMC3(DISRUPTS) 20551060; 21878504 2 17 0 +H3c1 H3 DNA-binding P68433 360198 13|13 A3.1 mouse K23-ac 458999 PRKQLATkAARKSAP Histone chromatin organization, altered 20067909 32 28 422 +FZR1 FZR1 UBIQUITIN LIGASE; Ubiquitin conjugating system Q9UM11 51343 19p13.3 human S40-p 3215931 PASSPVSsPSKHGDR protein stabilization; molecular association, regulation; activity, inhibited; phosphorylation apoptosis, induced APC(DISRUPTS); CDC27(DISRUPTS); APC1(DISRUPTS); CDC23(DISRUPTS) 18818692; 26083744; 26150388; 27080259; 30498084 5 13 2 inhibits cyclin B1 degradation; O-GlcNAcylation of FZR1 antagonizes its phosphorylation ; AURKA stabilization +PTK6 Brk EC 2.7.10.2; KINASE; Kinase, protein; Protein kinase, TK; Protein kinase, tyrosine (non-receptor) Q13882 5753 20q13.33 human Y342-p 450274 RLIKEDVyLSHDHNI PK_Tyr_Ser-Thr phosphorylation; enzymatic activity, induced signaling pathway regulation Brk(INDUCES) 12121988; 14676834; 34145060 4 4 45 induces DOK1 phosphorylation; regulates TCR/CD28 signaling +Skor1 SKOR1 Q8BX46 207667 9|9 B mouse Y234-p 1881001402 HRTPDAKyTQPDAAN molecular association, regulation carcinogenesis, induced; cell motility, induced; cell growth, induced; transcription, induced; cytoskeletal reorganization; signaling pathway regulation SMAD3(DISRUPTS) 36620935 1 0 0 induces Smad2/3 signaling +INCENP INCENP Cell cycle regulation; EC 2.7.11.1 Q9NQS7 3619 11q12.3 human S91-p 4273495 RRLSRRKsRSSQLSS molecular association, regulation; intracellular localization cell cycle regulation; cell growth, induced KIF20A(INDUCES) 33355621 2 4 3 alters CPC localization +SNAP91 SNAP-91 Vesicle O60641 9892 6q14.2 human S313-p 454326 SPATTVTsPNSTPAK molecular association, regulation PLD1(INDUCES) 21296491 1 10 5 +Optn optineurin Inhibitor Q8K3K8 71648 2 A1|2 3.15 cM mouse S476-p 9511914 AQMEVYCsDFHAERA CC2-LZ autophagy, induced 33931895 3 2 0 regulates mitochondrial homeostasis and pluripotency +SMARCAL1 SMARCAL1 EC 3.6.1.-; EC 3.6.4.-; Helicase Q9NZC9 50485 2q35 human S889-p 29606708 IYDLFQKsFEKEGSD enzymatic activity, induced 24150942 1 2 0 regulates ATPase activity, SMARCAL1 fork regression activity, +Scn2a SCN2A Channel, sodium; Membrane protein, integral; Membrane protein, multi-pass P04775 24766 3q21 rat S1126-p 6003507 TEEFSSEsDMEESKE Na_trans_assoc intracellular localization 19064667 1 0 0 regulates SCN2A accumulation at the axonal initial segment (AIS) and interaction with ankyrin G +MMP14 MMP14 EC 3.4.24.80; Membrane protein, integral; Motility/polarity/chemotaxis; Protease P50281 4323 14q11.2 human T567-p 7992400 FFFRRHGtPRRLLYC DUF3377 molecular association, regulation; intracellular localization; phosphorylation cell motility, induced; cell growth, induced; cell adhesion, induced; cell motility, altered; cell growth, altered ITGA5(INDUCES) 19458085; 22002060; 28655772 4 0 0 promote ovarian cancer intraperitoneal metastatic dissemination; increases cell migration and invasion ; required for MMP14 internalization and trafficking +JUN Jun Oncoprotein; Transcription factor P05412 3725 1p32.1 human T239-p 450450 VPEMPGEtPPLSPID Jun molecular association, regulation; ubiquitination cell motility, inhibited; transcription, inhibited FBXW7(INDUCES); FBXW7(DISRUPTS) DNA(DISRUPTS) 16023596; 21860413; 24632621 8 14 19 +WNK4 WNK4 EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, Other; Protein kinase, Ser/Thr (non-receptor) Q96J92 65266 17q21.2 human S335-p 456207 KRASFAKsVIGTPEF Pkinase enzymatic activity, induced 25542968 5 11 3 required for NCCT activation +TFEB TFEB DNA-binding; Transcription factor P19484 7942 6p21.1 human K116-ac 56403903 SPAQGSPkPPPAASP MITF_TFEB_C_3_N protein degradation; molecular association, regulation autophagy, inhibited; transcription, inhibited TFEB(DISRUPTS) DNA(DISRUPTS) 27209302; 31750630 3 1 0 suppresses TFEB transcriptional activity, knocking down dGcn5 in Drosophila eyes reduced hTau aggregation +CELF1 CELF1 Cell development/differentiation; RNA processing; RNA-binding Q92879 10658 11p11.2 human S52-p 25733984 INVLRDRsQNPPQSK RRM_1 RNA splicing, altered 24151077 1 1 7 splicing regulation in diabetes +XRCC1 XRCC1 DNA repair, damage P18887 7515 19q13.31 human S475-p 451509 IDIEGVQsEGQDNGA molecular association, regulation; intracellular localization PARP1(DISRUPTS); Pnk1(INDUCES) 15066279; 25477519 3 9 0 +TBXA2R TXA2-R iso2 GPCR, family 1; Membrane protein, integral; Membrane protein, multi-pass; Receptor, GPCR P21731-2 6915 19p13.3 human S239-p 469628 AQQRPRDsEVEMMAQ 7tm_1 molecular association, regulation; receptor desensitization, altered; receptor internalization, altered ARRB2(INDUCES) 16956790 1 0 0 +Psmc5 RPT6 Nuclear receptor co-regulator; Proteasome complex; Ubiquitin conjugating system P62196 19184 11|11 E1 mouse S120-p 483970 RVALRNDsYTLHKIL Prot_ATP_ID_OB enzymatic activity, induced 33658307 11 7 0 induces peptidase and ATPase activity +AGO2 AGO2 EC 3.1.26.n2; RNA processing; RNA-binding Q9UKV8 27161 8q24.3 human S798-p 17533105 VRCTRSVsIPAPAYY Piwi molecular association, regulation; activity, inhibited 26443379 2 1 0 abrogates association with RNA granules- P-bodies and stress granules, silencing activity is mildly affected +SRC Src EC 2.7.10.2; KINASE; Kinase, protein; Oncoprotein; Protein kinase, TK; Protein kinase, tyrosine (non-receptor) P00523 396442 chicken Y527-p 448235 FTSTEPQyQPGENL_ molecular association, regulation; enzymatic activity, inhibited; phosphorylation neural plasticity; cell motility, altered; cytoskeletal reorganization; cell adhesion, altered; cell growth, altered CSK(INDUCES); CSK(DISRUPTS) 11689444; 11909938; 1379736; 16024778; 17855352; 18614016; 2474754; 3103925; 3103926; 34616310; 7680096; 7687537 153 24 968 +Apba2 APBA2 Adaptor/scaffold P98084 11784 7 C|7 34.65 cM mouse S239-p 7151800 AEIKMSLsMTSITSA molecular association, regulation APP(INDUCES) 19222704 1 1 0 +SLC7A5 SLC7A5 Membrane protein, integral; Membrane protein, multi-pass; Transporter; Transporter, SLC family Q01650 8140 16q24.2 human K30-ub 6778622 REKMLAAkSADGSAP protein degradation endocytosis, induced 31728037 1 11 62 PMA-induced endocytosis +IRF3 IRF3 DNA-binding; Transcription factor Q14653 3661 19q13.33 human S396-p 449028 NTVDLHIsNSHPLSL protein degradation; protein stabilization; molecular association, regulation; activity, inhibited; enzymatic activity, induced; activity, induced; intracellular localization; protein conformation carcinogenesis, induced; autophagy, induced; apoptosis, induced; transcription, induced; transcription, altered CALCOCO2(INDUCES); IRF3(INDUCES); UBE3C(DISRUPTS); CBP(INDUCES) DNA(INDUCES) 12524442; 14703513; 18272581; 18440553; 19153595; 20511230; 23478265; 24371060; 25070846; 25636800; 27992402; 30842273; 32123095; 33411856; 33850055; 33883226; 33990776; 34379517; 34619149; 34965427; 35879450; 35948267; 36113429; 36417850; 36538592; 37330913; 9566918 75 6 0 GPR108 and Smurf1 mediated degradation requires NDP52; NDP52-dependent autophagic degradation of phosphorylated IRF3; GPR108 interacts with Smurf1, followed by the recruitment of IRF3 during viral infection +Cdk16 CDK16 Cell cycle regulation; EC 2.7.11.22; KINASE; Kinase, protein; Motility/polarity/chemotaxis; Protein kinase, CMGC; Protein kinase, Ser/Thr (non-receptor) Q04735 18555 X A1.3|X 16.18 cM mouse S110-p 453449 NHPPRKIsTEDINKR molecular association, regulation CCNYL1(INDUCES) 26305884 2 31 29 +ACO1 IREB1 Carbohydrate Metabolism - citrate (TCA) cycle; Carbohydrate Metabolism - glyoxylate and dicarboxylate; EC 4.2.1.3; Endoplasmic reticulum; Lyase; RNA-binding; Translation P21399 48 9p21.1 human S711-p 455225 REFNSYGsRRGNDAV Aconitase_C activity, inhibited 15636585 3 0 0 +Smad7 SMAD7 DNA-binding; Transcription factor O35253 17131 18|18 E3 mouse T96-p 15613800 EADLKALtHSVLKKL MH1 protein degradation; molecular association, regulation; enzymatic activity, inhibited apoptosis, inhibited; transcription, inhibited; signaling pathway regulation 29700281 2 0 0 negatively regulates and ASK1/TGF-beta/p53 signaling pathways.; inhibits MELK activity induces degradation +Oprd1 DOR-1 GPCR, family 1; Membrane protein, integral; Membrane protein, multi-pass; Receptor, GPCR P32300 18386 4 D2.3|4 64.78 cM mouse T361-p 448551 RERVTACtPSDGPGG intracellular localization 21220103 4 1 0 +EIF3J eIF3-alpha Translation; Translation initiation O75822 8669 15q21.1 human S127-p 3177700 LKKLQEEsDLELAKE eIF3_subunit molecular association, regulation translation, induced eIF3-eta(INDUCES); eIF3-zeta(INDUCES); EIF3C(INDUCES) 25887626 1 35 8 +AR AR DNA-binding; Nuclear receptor; Transcription factor P10275 367 Xq12 human Y225-p 1243004 PTSSKDNyLGGTSTI Androgen_recep transcription, induced 23906537 1 1 0 PSA expression +EPOR EPOR Membrane protein, integral; Receptor, cytokine P19235 2057 19p13.2 human Y456-p 455532 PPHLKYLyLVVSDSG molecular association, regulation apoptosis, inhibited SHIP(INDUCES); SOCS3(INDUCES) 10660611; 12027890; 14662339 8 0 0 +NR3C2 MCR DNA-binding; Nuclear receptor P08235 4306 4q31.23 human S936-p 1875398906 DSMHDLVsDLLEFCF Hormone_recep intracellular localization 34847273 1 0 0 +SNAP25 SNAP-25 Vesicle P60880 6616 20p12.2 human T138-p 449875 GGFIRRVtNDARENE SNAP-25 molecular association, regulation exocytosis, induced STX1A(DISRUPTS); SYT1(DISRUPTS) 17325194; 22311984 7 5 3 +XRCC1 XRCC1 DNA repair, damage P18887 7515 19q13.31 human K298-ac 474774 AQGAVTGkPRGEGTE protein degradation 31043584 1 3 6 +RIPK1 RIPK1 EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, Ser/Thr (non-receptor); Protein kinase, TKL Q13546 8737 6p25.2 human S357-p 1868502603 GMGPVEEsWFAPSLE molecular association, regulation apoptosis, inhibited RIPK3(DISRUPTS) 32320653 1 1 0 +CYCS CYCS Apoptosis; Mitochondrial; Oxidoreductase; PHOSPHATASE; Protein phosphatase, Ser/Thr (non-receptor) P99999 54205 7p15.3 human Y47-p 3416311 KTGQAPGySYTAANK Cytochrom_C enzymatic activity, inhibited apoptosis, inhibited 32781572 1 0 3 inhibits cytochrome c oxidase activity +LIG1 LIG1 DNA repair, damage; EC 6.5.1.1; Ligase P18858 3978 19q13.33 human S91-p 2999200 ALDCSQVsPPRPATS molecular association, regulation; intracellular localization; phosphorylation cell growth, altered RFC1(INDUCES); RAD17(DISRUPTS) 12851383; 19223468 3 10 1 primes other LIG1 phosphorylations; regulates DNA replication and repair +CYLD CYLD DEUBIQUITINASE; EC 3.4.19.12; Protease; Tumor suppressor; Ubiquitin conjugating system; Ubiquitin-specific protease Q9NQC7 1540 16q12.1 human S568-p 1874990002 LAFGGYLsEVVEENT ubiquitination; enzymatic activity, induced signaling pathway regulation 34610306 1 1 0 induces RIPK2 deubiquitination, and NOD2 signaling +SOX2 SOX2 Cell development/differentiation; DNA-binding; Transcription factor P48431 6657 3q26.33 human T256-p 1883303000 SSSPPVVtSSSHSRA phosphorylation 37349645 1 0 0 primes phosphorylation at S251 +KCNH2 Kv11.1 Channel, potassium; Membrane protein, integral; Membrane protein, multi-pass; Motility/polarity/chemotaxis Q12809 3757 7q36.1 human S283-p 4696779 CASVRRAsSADDIEA activity, induced; molecular association, regulation; activity, inhibited signaling pathway regulation 14-3-3 eta(INDUCES) 10488078; 10837251; 11953308 3 5 0 +Syngap1 SynGAP GAP; GAP, Ras F6SEU4 240057 17|17 A3.3 mouse T790-p 33636249 MARLPSPtKEKPPPP DUF3498 activity, inhibited 25533468 1 2 6 S788D and T790D mutations inhibit Rap2 GAP and HRas GAP activities of SynGAP +DNMT1 DNMT1 Amino Acid Metabolism - cysteine and methionine; Cell development/differentiation; EC 2.1.1.37; METHYLTRANSFERASE; Methyltransferase; Methyltransferase, DNA; Transcription regulation P26358 1786 19p13.2 human K1135-sm 12726301 SEPEIEIkLPKLRTL enzymatic activity, induced DNA(INDUCES) 19450230 1 0 0 +YY1 YY1 C2H2-type zinc finger protein; Cell development/differentiation; Transcription factor P25490 7528 14q32.2 human S184-p 476106 GKKSGKKsYLSGGAG molecular association, regulation DNA(INDUCES) 23226345 2 3 1 +HCN4 HCN4 Channel, cation; Membrane protein, integral; Membrane protein, multi-pass Q9Y3Q4 10021 15q24.1 human Y531-p 1240811 RRQYQEKyKQVEQYM activity, induced 17977941 1 0 0 +Homer2 HOMER2 Actin-binding; Adaptor/scaffold Q9QWW1 26557 7|7 D3 mouse S216-p 51633301 EQWKRQFsICRDEND molecular association, regulation mGluR5(DISRUPTS); GluR5(DISRUPTS) 26670047; 36973011 2 0 0 +Camk2d CAMK2D EC 2.7.11.17; KINASE; Kinase, protein; Protein kinase, CAMK; Protein kinase, Ser/Thr (non-receptor) Q6PHZ2 108058 3|3 G1 mouse T287-p 450982 SMMHRQEtVDCLKKF apoptosis, induced 26726877 15 32 148 myocardial necroptosis, inflammation +Dcp1a DCP1A EC 3.-.-.-; Hydrolase; RNA processing; Transcription, coactivator/corepressor Q91YD3 75901 14 B|14 18.75 cM mouse S339-p 3213297 LPLSPVLsPTLPAEA molecular association, regulation DCP2(INDUCES) 23637887 3 25 7 +SERPINA3 SERPINA3 Secreted; Secreted, signal peptide P01011 12 14q32.13 human K421-ac 464675 MSKVTNPkQA_____ molecular association, regulation DNA(INDUCES) 7782318 1 0 0 +CCR7 CCR7 GPCR, family 1; Membrane protein, integral; Membrane protein, multi-pass; Motility/polarity/chemotaxis; Receptor, GPCR P32248 1236 17q21.2 human T374-p 455289 SVEAETTtTFSP___ phosphorylation 15054093 1 0 0 ERK1/2 phosphorylation +FEN1 FEN1 DNA repair, damage; DNA-binding; Deoxyribonuclease; EC 3.1.-.-; Nuclear receptor co-regulator; Nucleolus; Ribonuclease P39748 2237 11q12.2 human K200-sc 33357717 HLTASEAkKLPIQEF XPG_I molecular association, regulation; methylation cell cycle regulation; DNA repair, induced RAD1(INDUCES); HUS1(INDUCES) 32783654 1 1 0 R192 methylation inhibits succinylation +NFKB1 NFkB-p105 iso2 DNA-binding; Transcription factor P19838-2 4790 4q24 human Y82-p 1880539208 SEKNKKSyPQVKICN molecular association, regulation transcription, altered DNA(INDUCES) 36534507 1 0 0 +Wasf1 WAVE1 Cytoskeletal; Motility/polarity/chemotaxis Q5BJU7 rat S310-p 4764996 LIENRPQsPAAGRTP intracellular localization cytoskeletal reorganization 19460862 4 8 0 +IKBKG IKKG Adaptor/scaffold; Protein kinase, regulatory subunit Q9Y6K9 8517 Xq28 human K309-ub 486355 KAQADIYkADFQAER CC2-LZ ubiquitination apoptosis, inhibited; transcription, induced; signaling pathway regulation 14651848; 19136968; 19223549; 21811235; 23453807 7 8 0 regulates NF-kB ignaling and mitochondrial integrity; activation of TAK1 IKK and NF-kB after genotoxic stress +MTA1 MTA1 Motility/polarity/chemotaxis; Nuclear receptor co-regulator; Transcription, coactivator/corepressor Q13330 9112 14q32.33 human K509-sm 25171014 PINSAAIkAECTARL MTA_R1 transcription, inhibited 21965678 2 0 0 +SPHK2 SPHK2 EC 2.7.1.91; Kinase, lipid; Lipid Metabolism - sphingolipid Q9NRA0 56848 19q13.33 human S387-p 477181 PATVEPAsPTPAHSL cell motility, altered 17311928 1 11 0 +Erbb3 HER3 EC 2.7.10.1; KINASE; Kinase, protein; Membrane protein, integral; Oncoprotein; Protein kinase, TK; Protein kinase, tyrosine (receptor) Q62799 29496 7q11 rat Y1051-p 449859 LLSPSSGyMPMNQSS molecular association, regulation; phosphorylation PIK3CB(INDUCES); PIK3R1(INDUCES) 11546794 3 2 20 induces phosphorylation of Akt1. +EEF1A1 EEF1A1 Nucleolus; Translation; Translation elongation P68104 1915 6q13 human K318-m2 12193411 NVKNVSVkDVRRGNV GTP_EFTU_D2 molecular association, regulation L3MBTL iso4(INDUCES) 23583077 0 2 3 +CCNT1 CCNT1 Cell cycle regulation; Transcription initiation complex O60563 904 12q13.11-q13.12 human K380-ac 25174701 ISQKQNSkSVPSAKV molecular association, regulation; enzymatic activity, induced transcription, induced BCDIN3(DISRUPTS); HEXIM1(DISRUPTS); BRD4(INDUCES) RNA(DISRUPTS) 19387490; 22084242 3 1 0 Interaction with BRD4 disrupts interaction with HEXIM1 and 7SK snRNA; enhances CDK9/cyclin T1 transcriptional activity, disrupting HEXIM1 and BCDIN3 association +TUBB3 TUBB3 Cytoskeletal; Motility/polarity/chemotaxis Q13509 10381 16q24.3 human S444-p 451154 YEDDEEEsEAQGPK_ cytoskeletal reorganization 26586574 3 0 2 microtubule stabilization, affects cytokinesis through TUBB3 S444 phosphorylation, +PLK1 PLK1 EC 2.7.11.21; KINASE; Kinase, protein; Protein kinase, Other; Protein kinase, Ser/Thr (non-receptor) P53350 5347 16p12.2 human T210-p 448139 YDGERKKtLCGTPNY Pkinase protein stabilization; molecular association, regulation; ubiquitination; intracellular localization; phosphorylation; enzymatic activity, induced cell cycle regulation; carcinogenesis, induced; carcinogenesis, inhibited; cell motility, induced; transcription, altered; DNA repair, induced; autophagy, induced; cell growth, induced; chromatin organization, altered; cytoskeletal reorganization CHFR(DISRUPTS); PLK1(DISRUPTS) 10980711; 11854496; 12207013; 15713655; 18615013; 22281053; 24349352; 24844881; 25660017; 26114094; 26206521; 26242183; 27002159; 27068477; 27721411; 30021153; 30626720; 31597699; 32060423; 33771996; 33805672; 34140642; 34197606; 34260926; 34758324; 34759346; 34775484; 36231009 59 31 45 +Pdx1 PDX1 DNA-binding; Transcription factor P52947 29535 12p11 rat S66-p 458402 QGSPPDIsPYEVPPL activity, induced; molecular association, regulation transcription, induced p300(INDUCES) 15001545 3 0 0 +NFATC1 NFAT2 DNA-binding; Transcription factor O95644 4772 18q23 human S256-p 1869090802 ESWLGARsSRPASPC activity, induced carcinogenesis, induced; cell motility, induced; transcription, induced 31730483 1 1 0 multiple sites mutatnt +HNRNPK hnRNP K RNA splicing; RNA-binding; Spliceosome P61978 3190 9q21.32 human R296-m2 476739 PPPPPPGrGGRGGSR protein stabilization; phosphorylation cell motility, induced 17191129; 31110205 3 6 8 +Rhbdf2 RHBDL6 Membrane protein, integral; Membrane protein, multi-pass Q80WQ6 217344 11|11 E2 mouse S83-p 4751502 PGFRRQAsLSQSIRK molecular association, regulation 29045841 1 30 35 recruitment- co-immunoprecipitation with 14-3-3 proteins; impaired TACE shedding on the cell surface +KAT7 MYST2 ACETYLTRANSFERASE; Acetyltransferase; EC 2.3.1.48; Nuclear receptor co-regulator; Transcription, coactivator/corepressor O95251 11143 17q21.33 human T331-p 18911980 LRLQGQItEGSNMIK protein stabilization; acetylation; ubiquitination cell growth, induced 33014433 2 3 0 inhibits ubiquitination mediated degradation +FOXC2 FOXC2 Apoptosis; Cell development/differentiation; DNA-binding; Transcription factor Q99958 2303 16q24.1 human S288-p 3210591 SPPGGELsPGAGRAG molecular association, regulation transcription, altered DNA(INDUCES) 23878394 1 8 0 implicated in vascular remodeling in vivo +HSF1 HSF1 DNA-binding; Transcription factor Q00613 3297 8q24.3 human S307-p 449046 EPPSPPQsPRVEEAS Vert_HS_TF protein degradation; sumoylation; molecular association, regulation; intracellular localization; activity, inhibited; phosphorylation transcription, induced; transcription, inhibited 14-3-3 epsilon(INDUCES) 12646186; 12917326; 16624816; 25679764; 25963659; 33493517; 8940068; 9535852 26 56 3 +Grik5 GluR KA2 Channel, ligand-gated; Membrane protein, integral; Membrane protein, multi-pass Q63273 24407 1q21 rat S859-p 27535800 AVSCRKTsRSRRRRR molecular association, regulation PSD-95(DISRUPTS) 23288040 1 0 0 necessary for KAR-LTD; increases expression of KARs at the plasma membrane; reduced at dendritic spines; increases lateral mobility of KARs +CAPN2 CAPN2 EC 3.4.22.53; Motility/polarity/chemotaxis; Protease P17655 824 1q41 human T370-p 451304 GNWRRGStAGGCRNY Calpain_III activity, inhibited cell motility, altered 11909964 2 0 0 +Plcg1 PLCG1 Carbohydrate Metabolism - inositol phosphate; EC 3.1.4.11; Motility/polarity/chemotaxis; Phospholipase P10686 25738 3q42 rat Y783-p 447667 EGRNPGFyVEANPMP intracellular localization; enzymatic activity, induced 1708307; 17113383; 19179337; 20164676 92 42 558 +MCM2 MCM2 DNA-binding; EC 3.6.4.12 P49736 4171 3q21.3 human S13-p 473057 ESFTMASsPAQRRRG molecular association, regulation chromatin organization, altered DNA(INDUCES) 16446360 2 33 5 MMCM2 phosphorylated forms are differentially bound to chromatin. +Tfeb TFEB DNA-binding; Transcription factor Q9R210 21425 17 C|17 23.99 cM mouse S141-p 3181628 AGNSAPNsPMAMLHI MITF_TFEB_C_3_N intracellular localization autophagy, induced; transcription, induced 35948663 13 12 0 +Gja1 GJA1 Channel, misc.; Membrane protein, integral; Membrane protein, multi-pass; Motility/polarity/chemotaxis P08050 24392 20q11 rat S368-p 447813 QRPSSRAsSRASSRP activity, induced; intracellular localization; activity, inhibited cell motility, induced; cell growth, induced 10871288; 12417300; 29021339; 30740090; 34428599; 34698450 57 8 1 +GRB10 GRB10 Adaptor/scaffold Q13322 2887 7p12.1 human S428-p 455333 STPVRSVsENSLVAM BPS protein stabilization 21659604 2 8 0 +GPNMB GPNMB Membrane protein, integral Q14956 10457 7p15.3 human S542-p 12738565 VVRSKGLsVFLNRAK carcinogenesis, induced; cell motility, induced; cell growth, induced; transcription, altered 34327762 1 6 0 +Prkaa2 AMPKA2 Autophagy; EC 2.7.11.1; EC 2.7.11.27; EC 2.7.11.31; KINASE; Kinase, protein; Protein kinase, CAMK; Protein kinase, Ser/Thr (non-receptor) Q09137 78975 5q34 rat S491-p 450432 STPQRSCsAAGLHRP AdenylateSensor enzymatic activity, inhibited 17032173 13 12 2 +Map2 MAP2 iso3 Cytoskeletal; Motility/polarity/chemotaxis P15146-3 25595 9q32 rat K282-ac 62495502 GILVPSEkKVAIIRT cytoskeletal reorganization 28002468 1 1 0 +Sstr2 SSTR2 GPCR, family 1; Membrane protein, integral; Membrane protein, multi-pass; Receptor, GPCR P30680 rat T356-p 12577701 RLNETTEtQRTLLNG activity, induced; intracellular localization; receptor internalization, altered signaling pathway regulation 20051480; 21795688 6 0 0 Dephosphorylation is initiated directly after receptor activation at or near the plasma membrane; leads to disruption of the ?-arrestin- GPCR complex +POLB POLB DNA repair, damage; DNA replication; EC 2.7.7.7; Lyase; Transferase P06746 5423 8p11.21 human K244-ub 56841100 GVCQLPSkNDEKEYP DNA_pol_B_palm protein degradation; ubiquitination 25423885 1 0 0 +DPYSL2 CRMP-2 iso3 Microtubule-binding; Motility/polarity/chemotaxis NP_001184222 1808 8p21.2 human T614-p 448083 PVCEVSVtPKTVTPA carcinogenesis, altered; cell motility, altered 24036111 16 63 34 +Fosl2 FRA2 DNA-binding; Transcription factor P47930 14284 5 B1|5 17.33 cM mouse S320-p 4707550 QSSDSLNsPTLLAL_ protein stabilization cell differentiation, inhibited 23807221 2 14 11 +Smo SMO Cell development/differentiation; GPCR, Fz/Smo family; Membrane protein, integral; Membrane protein, multi-pass; Oncoprotein; Receptor, GPCR P56726 319757 6 A3.3|6 12.36 cM mouse T644-p 1872776122 LPQDVSVtPVATPVP molecular association, regulation transcription, induced PKACA(INDUCES) 33886552 1 1 0 +Pecam1 PECAM-1 Cell adhesion; Cell development/differentiation; Membrane protein, integral; Motility/polarity/chemotaxis Q08481 18613 11|11 E1 mouse Y679-p 448759 PQNMDVEyTEVEVSS molecular association, regulation SHP-2(INDUCES); SHP-1(INDUCES) 9624175 9 0 44 Y679 A.K.A. Y663 +TUBB5 TUBB Cytoskeletal; Motility/polarity/chemotaxis Q2KJD0 cow Y281-p 15406726 TSRGSQQyRALTVPE Tubulin_C cytoskeletal reorganization 19631231 0 1 20 +Cyp2c7 CYP2C39 EC 1.14.14.1; Oxidoreductase P05179 29298 1q31 rat K200-ac 4611500 EMLTFMEkVNENLKI p450 cell differentiation, induced; transcription, induced 18834332 1 0 0 Could be necessary for full differentiation of acinar cells +Ndufa1 NDUFA1 EC 1.6.5.3; EC 1.6.99.3; Energy Metabolism - oxidative phosphorylation; Membrane protein, integral; Mitochondrial; Oxidoreductase Q9WU08 100689328 hamster S55-p 486441 MERDRRVsGVNRYYV MWFE enzymatic activity, induced 17931954 1 1 0 S55 contributes to complex assembly and enzymatic activation. +TET2 TET2 EC 1.14.11.n2; Oxidoreductase; Tumor suppressor Q6N021 54790 4q24 human Y1964-p 1870020001 HETSEPTyLRFIKSL activity, induced; molecular association, regulation; phosphorylation cell differentiation, induced; signaling pathway regulation KLF1(INDUCES) 30944118 1 0 0 +MCRIP1 FAM195B C9JLW8 348262 17q25.3 human S21-p 486127 KRTSSPRsPPSSSEI FAM195 molecular association, regulation transcription, induced CTBP1(DISRUPTS) 25728771 1 46 2 freed CtBP binds to ZEB1, regulates epithelial-mesenchymal transition (EMT). +MTHFR MTHFR Cofactor and Vitamin Metabolism - one carbon pool by folate; EC 1.5.1.20; Energy Metabolism - methane; Oxidoreductase P42898 4524 1p36.22 human T549-p 178601701 NVKGENItNAPELQP cell cycle regulation 28820331 1 0 0 +KCNQ1 Kv7.1 Channel, potassium; Membrane protein, integral; Membrane protein, multi-pass P51787 3784 11p15.5-p15.4 human K424-sm 1873173302 VVKKKKFkLDKDNGV sumoylation 28743749 1 0 0 A SUMO shifts the half-maximal activation voltage and produces a maximal+34-mV shift. +AKT1 Akt1 EC 2.7.11.1; KINASE; Kinase, protein; Oncoprotein; Protein kinase, AGC; Protein kinase, Ser/Thr (non-receptor) P31749 207 14q32.33 human T211-p 28706901 NSRHPFLtALKYSFQ Pkinase signaling pathway regulation 23768697 0 1 0 PI3K-Akt-eNOS signaling pathway +Ncam1 NCAM1 Cell adhesion; Membrane protein, GPI anchor; Membrane protein, integral; Motility/polarity/chemotaxis P13595 17967 9 A5.3|9 26.83 cM mouse Y734-p 454070 VVMDITCyFLNKCGL cell growth, altered 20605779 2 0 0 +CDC25A CDC25A EC 3.1.3.48; Motility/polarity/chemotaxis; PHOSPHATASE; Protein phosphatase, dual-specificity P30304 993 3p21.31 human S178-p 449126 LFTQRQNsAPARMLS M-inducer_phosp activity, induced; protein degradation; molecular association, regulation; intracellular localization 14-3-3 beta(INDUCES) 12676583; 14559997; 36539837 4 1 0 nuclear-cytoplasmic redistribution +POLM POLM DNA repair, damage; EC 2.7.7.7; Transferase Q9NP87 27434 7p13 human S12-p 469477 RRRARVGsPSGDAAS molecular association, regulation; enzymatic activity, inhibited DNA(DISRUPTS) 23933132 1 20 7 +Sp7 osterix C2H2-type zinc finger protein; DNA-binding; Transcription factor Q8VI67 170574 15|15 F3 mouse K55-ub 31914106 YADLSAPkTMGDAYP protein degradation cell differentiation, inhibited; transcription, induced 25818514 2 0 0 inhibits BMP signaling +MC1R MC1R GPCR, family 1; Membrane protein, integral; Membrane protein, multi-pass; Receptor, GPCR Q01726 4157 16q24.3 human T157-p 8051400 LRYHSIVtLPRARRA 7tm_1 exocytosis, altered 19452503 1 0 1 rescues the retention phenotype of R160W and R162P +IRS4 IRS4 Adaptor/scaffold O14654 8471 Xq22.3 human Y779-p 10781335 DNDSESDyMFMAPGA molecular association, regulation cell cycle regulation; carcinogenesis, induced; cell growth, induced; signaling pathway regulation EBNA1BP2(INDUCES); PIK3R2(INDUCES) 35550247 1 2 3 induces the PI3K-AKT signaling pathway +EP300 p300 ACETYLTRANSFERASE; Acetyltransferase; EC 2.3.1.48; Motility/polarity/chemotaxis; Nuclear receptor co-regulator; Transcription, coactivator/corepressor Q09472 2033 22q13.2 human K1024-ac 458945 TELKTEIkEEEDQPS activity, inhibited transcription, inhibited 15632193 1 1 0 +HSP90AA1 HSP90A Chaperone; Heat shock protein P07900 3320 14q32.31 human T36-p 15410982 LMSLIINtFYSNKEI activity, induced; protein stabilization; molecular association, regulation; enzymatic activity, inhibited CDK4(DISRUPTS); HER2(DISRUPTS); Src(DISRUPTS); CCDC37(DISRUPTS); AHSA1(DISRUPTS) 21419342 1 0 0 increase CFTR stability and GR activity +OXSR1 OSR1 EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, STE; Protein kinase, Ser/Thr (non-receptor) O95747 9943 3p22.2 human T185-p 456503 TRNKVRKtFVGTPCW Pkinase activity, induced; molecular association, regulation; enzymatic activity, induced CAB39(INDUCES) 16083423; 17190791; 18270262; 22032326; 25389294; 29581290 12 6 51 Double knock in lacks its activity; cell volume control dependent on its kinase activity; 2.5-fold increase in Kir2.1 channel activity when cotransfected compared to Kir2.1 alone +KAT2A GCN5 ACETYLTRANSFERASE; Acetyltransferase; EC 2.3.1.48 Q92830 2648 17q21.2 human S372-p 33703201 EEIYGANsPIWESGF acetylation; enzymatic activity, induced 24870244 1 0 0 enhanced acetyltransferase acivity, PGC-1a acetylation, suppresses gluconeogenesis +Braf BRAF EC 2.7.11.1; KINASE; Kinase, protein; Oncoprotein; Protein kinase, Ser/Thr (non-receptor); Protein kinase, TKL F1M9C3 114486 4q22 rat S347-p 450243 GQRDRSSsAPNVHIN molecular association, regulation; enzymatic activity, inhibited cell growth, altered 14-3-3 beta(INDUCES) 17074813 9 27 30 stimulates cell proliferation +SP1 SP1 C2H2-type zinc finger protein; DNA-binding; Transcription factor P08047 6667 12q13.13 human S702-gl 5262509 FMRSDHLsKHIKTHQ zf-C2H2 transcription, induced 18513490 2 1 0 +FOSL1 FRA1 DNA-binding; Transcription factor P15407 8061 11q13.1 human S252-p 478351 ASAHRKSsSSSGDPS molecular association, regulation; protein stabilization carcinogenesis, induced; cell motility, induced; cell growth, induced; cytoskeletal reorganization AXL(INDUCES) 17371847; 21822309; 22286759 3 1 3 +NPM1 NPM1 Nucleolus; Oncoprotein; RNA-binding; Translation P06748 4869 5q35.1 human S70-p 459898 EAMNYEGsPIKVTLA Nucleoplasmin protein stabilization; molecular association, regulation; intracellular localization; phosphorylation cell cycle regulation CDC25C(INDUCES); ARF1(INDUCES) 19933706; 23851489 4 88 30 mutation of S10/S70 to alanine increases CDK1 Y15 phosphorylation; increase ARF protein stabilization; mutation of S10/70 to glutamate decreases Cdc25C S216 phosphorylation +YAP1 YAP1 Oncoprotein; Transcription, coactivator/corepressor P46937 10413 11q22.1 human K76-ub 1883364801 FNAVMNPkTANVPQT protein degradation; ubiquitination carcinogenesis, inhibited; apoptosis, induced; cell motility, inhibited 36280829 1 0 0 +Sntb2 SNTB2 Adaptor/scaffold; Dystrophin complex; Extracellular matrix Q61235 20650 8 D3|8 53.38 cM mouse S75-p 471147 NRGLGPPsPPAPPRG molecular association, regulation; intracellular localization exocytosis, altered PTPRN(DISRUPTS) 20886068 1 75 6 +NPM1 NPM1 Nucleolus; Oncoprotein; RNA-binding; Translation P06748 4869 5q35.1 human K230-ac 6216434 KGQESFKkQEKTPKT molecular association, regulation; intracellular localization transcription, altered H3(INDUCES) 19581289 1 1 4 K212/215/229/230/257/267/292R mutant +Eif4ebp1 4E-BP1 Translation; Translation initiation Q62622 116636 16q12.3 rat T36-p 447497 PPGDYSTtPGGTLFS eIF_4EBP molecular association, regulation; phosphorylation translation, altered EIF4E(DISRUPTS) 10779345; 20736160; 9806882 159 44 88 +PAK1 PAK1 EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, STE; Protein kinase, Ser/Thr (non-receptor) Q13153 5058 11q13.5-q14.1 human T109-p 14150103 QWARLLQtSNITKSE PBD enzymatic activity, inhibited 20400510 1 1 0 in vitro +CASP8 CASP8 Apoptosis; EC 3.4.22.61; Protease Q14790 841 2q33.1 human S387-p 16855100 YLEMDLSsPQTRYIP Peptidase_C14 molecular association, regulation; protein processing; intracellular localization; enzymatic activity, inhibited; protein conformation; phosphorylation cell cycle regulation; apoptosis, altered; carcinogenesis, altered; apoptosis, inhibited PLK1(INDUCES) 20937773; 24342355; 24484936; 26036637; 29233910 5 2 0 mitosis; impairs erlotinib-induced procaspase-8 homodimerization +KLRC1 NKG2A Membrane protein, integral; Receptor, misc. P26715 3821 12p13.2 human Y40-p 455556 ATEQEITyAELNLQK activity, induced; molecular association, regulation; intracellular localization SHP-1(INDUCES) 12165520 1 0 0 +AHR AHR DNA-binding; Transcription factor P35869 196 7p21.1 human S444-p 1874101920 GKDSATTsTLSKDSL protein degradation; ubiquitination autophagy, induced; transcription, induced 34198826 1 0 0 +ADRA1D ADRA1D GPCR, family 1; Membrane protein, integral; Membrane protein, multi-pass; Receptor, GPCR P25100 146 20p13 human T442-p 1346843004 GHHWRAStSGLRQDC receptor internalization, altered signaling pathway regulation 29551601 2 1 0 regulates ERK signaling pathway, induces calcium signaling de-sensitization +IGFBP3 IGFBP3 Cell development/differentiation; Secreted; Secreted, signal peptide P17936 3486 7p12.3 human S140-p 451463 APGNASEsEEDRSAG apoptosis, induced 12210764 3 0 0 +CHEK2 Chk2 EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, CAMK; Protein kinase, Ser/Thr (non-receptor); Tumor suppressor O96017 11200 22q12.1 human Y156-p 1877718908 EVGPKNSyIAYIEDH FHA molecular association, regulation cell cycle regulation; chromatin organization, altered TTK(INDUCES) 35851582 1 1 0 induces HEC1 binding to TTK +EGFR EGFR EC 2.7.10.1; KINASE; Kinase, protein; Membrane protein, integral; Oncoprotein; Protein kinase, TK; Protein kinase, tyrosine (receptor) P00533 1956 7p11.2 human S1039-p 3178884 TPLLSSLsATSNNST receptor internalization, induced; protein degradation endocytosis, induced 24797263; 36184515 3 11 0 +EPS8 EPS8 Adaptor/scaffold Q12929 2059 12p12.3 human Y602-p 450736 LGRADPPyTHTIQKQ cell cycle regulation; cell motility, induced; cell growth, induced; transcription, induced 32641864 2 4 11 +Nfkb1 NFkB-p105 DNA-binding; Transcription factor P25799 18033 3 G3|3 62.82 cM mouse S326-p 22771100 VNITKPAsVFVQLRR RHD_dimer molecular association, regulation; protein conformation transcription, induced; transcription, altered p53(INDUCES) 29873020; 30940658 4 1 0 regulates MALAT1 expression +MPHOSPH8 MPHOSPH8 Cell cycle regulation Q99549 54737 13q12.11 human K439-ac 40709504 RKEPKGLkTLKEIRN protein degradation; ubiquitination 25870236 1 1 0 +Top2b TOP2B Cell development/differentiation; DNA-binding; EC 5.99.1.3; Motility/polarity/chemotaxis; Nucleolus; Topoisomerase Q64511 21974 14|14 A2 mouse S1511-p 459995 VETINSDsDSEFGIP DTHCT transcription, inhibited 36206766 1 83 11 +GRAP2 GADS Adaptor/scaffold O75791 9402 22q13.1 human Y45-p 451894 ELGSQEGyVPKNFID SH3_1 transcription, induced; signaling pathway regulation 33931484 1 5 95 induces TCR signaling +SQSTM1 SQSTM1 Autophagy; Nuclear receptor co-regulator; Ubiquitin conjugating system Q13501 8878 5q35.3 human K13-ub 10840244 VKAYLLGkEDAAREI protein degradation 26746706 1 9 48 +RANBP3 RANBP3 iso3 Adaptor/scaffold Q9H6Z4-3 8498 19p13.3 human S58-p 460735 VKRERTSsLTQFPPS molecular association, regulation; intracellular localization transcription, induced; signaling pathway regulation PPPM1A(INDUCES) 21960005 3 46 126 nuclear export of Smad2/3 inhibited +ELAVL1 HuR RNA-binding Q15717 1994 19p13.2 human S318-p 2246702 GDKILQVsFKTNKSH protein degradation; molecular association, regulation; intracellular localization cell cycle regulation; carcinogenesis, altered; apoptosis, induced; cell motility, altered 14-3-3 theta(INDUCES) RNA(INDUCES); RNA(NOT_REPORTED); RNA(DISRUPTS) 18285462; 20086103; 21310943; 23115237; 23978401; 24492650; 25584704 8 3 0 increases cell migration and proliferation; regulates post-transcriptional HuR functionality +MDC1 MDC1 Cell cycle regulation Q14676 9656 6p21.33 human T404-p 3196400 SMVINSDtDDEEEVS molecular association, regulation cell cycle regulation NBS1(INDUCES) 18678890 1 24 6 MDC1-NBS1 interaction regulates intra-S-phase checkpoint activation +SIT1 SIT Adaptor/scaffold; Membrane protein, integral Q9Y3P8 27240 9p13.3 human Y188-p 448962 ASFPDQAyANSQPAA molecular association, regulation GRB2(INDUCES) 11433379 1 6 194 Y90 is major binding site. +KCNA1 Kv1.1 Channel, potassium; Membrane protein, integral; Membrane protein, multi-pass Q09470 3736 12p13.32 human S446-p 451079 SDLSRRSsSTMSKSE intracellular localization carcinogenesis, induced; transcription, inhibited; signaling pathway regulation 23774215 2 0 0 PKA-Kv1.1 pathway +Nphs1 NPHS1 Cell adhesion; Immunoglobulin superfamily; Membrane protein, integral Q9QZS7 54631 7|7 B1 mouse T1134-p 18507016 EYEESQWtGDRDTRS endocytosis, induced 35451598 2 0 0 +ACP1 ACP1 Cofactor and Vitamin Metabolism - riboflavin; EC 3.1.3.2; EC 3.1.3.48; Motility/polarity/chemotaxis; PHOSPHATASE; Phosphatase (non-protein); Protein phosphatase, tyrosine (non-receptor) Q3SZ94 280977 cow Y133-p 457445 LIIEDPYyGNDADFE LMWPc molecular association, regulation GRB2(INDUCES) 10452533 5 6 81 +Ptk2 FAK EC 2.7.10.2; KINASE; Kinase, protein; Protein kinase, TK; Protein kinase, tyrosine (non-receptor) P34152 14083 15 D3|15 33.94 cM mouse S910-p 447964 KLQPQEIsPPPTANL molecular association, regulation PXN(DISRUPTS) 12692126 20 48 0 +MAP3K20 ZAK EC 2.7.11.25; KINASE; Kinase, protein; Protein kinase, Ser/Thr (non-receptor); Protein kinase, TKL Q9NYL2 51776 2q31.1 human S165-p 455379 HNHTTHMsLVGTFPW PK_Tyr_Ser-Thr enzymatic activity, induced 15342622 1 0 0 +Cttn Cortactin Actin-binding; Cytoskeletal; Motility/polarity/chemotaxis Q60598 13043 7|7 F5 mouse K309-ac 461724 YAKGFGGkYGVQKDR HS1_rep molecular association, regulation; acetylation; intracellular localization DIP2A(INDUCES) 31600191 2 4 20 DIP2A regulates spine morphology and synaptic transmission through acetylation of cortactin; Interaction of DIP2A-cortactin is required for acetylated cortactin; acetylation mimetic cortactin rescues the repetitive behaviors in Dip2a KO mice; acetylation alleviated abnormal PSD95 clustering at the spine head in DIP2A KO neurons +CYBB CYBB EC 1.-.-.-; Membrane protein, integral; Membrane protein, multi-pass; Mitochondrial; Oxidoreductase P04839 1536 Xp21.1-p11.4 human S486-p 241497500 YLTGWDEsQANHFAV NAD_binding_6 enzymatic activity, inhibited 28916473 1 1 0 +BCL10 Bcl-10 Apoptosis; Transcription, coactivator/corepressor; Tumor suppressor O95999 8915 1p22.3 human K31-ub 2134711 LRVYLCEkIIAERHF CARD activity, induced; protein degradation; molecular association, regulation; intracellular localization carcinogenesis, induced; transcription, induced; signaling pathway regulation IKKG(INDUCES) 18287044; 27070702; 27777308 3 1 0 promote NF-kB activation, cIAP1/2-mediated polyubiquitination is necessary for the recruitment of LUBAC to the CBM complex; TCR-mediated NF-?B activation +Kcnd2 Kv4.2 Channel, potassium; Membrane protein, integral; Membrane protein, multi-pass Q63881 rat S552-p 450462 VSGSHRGsVQELSTI intracellular localization 12829703; 18650329 6 8 0 important for Kv4.2 internalization in hippocampal neurons; S552 phosphorylation occurs in response to plasma membrane localization. +NCAPH NCAPH Cell cycle regulation Q15003 23397 2q11.2 human S70-p 3196694 ERLQRRRsRVFDLQF Cnd2 molecular association, regulation; intracellular localization DNA(INDUCES) 28817632 1 10 11 +APH1A APH1A Apoptosis; Endoplasmic reticulum; Membrane protein, integral; Membrane protein, multi-pass Q96BI3 51107 1q21.2 human S251-p 1877641906 LCRRQEDsRVMVYSA molecular association, regulation; enzymatic activity, altered ARRB2(INDUCES) 35858570 1 1 0 +VAV1 VAV1 GEF; GEF, Rac/Rho; Motility/polarity/chemotaxis; Oncoprotein P15498 7409 19p13.3 human Y841-p 464357 ANYVEEDySEYC___ activity, induced; molecular association, regulation carcinogenesis, altered; cell growth, altered Src(INDUCES); PLCG1(INDUCES); SH2-B-beta(INDUCES); Brk(INDUCES) 20457609 1 1 47 +ETV1 ETV1 DNA-binding; Oncoprotein; Transcription factor P50549 2115 7p21.2 human S146-p 3059603 TPSSTPVsPLHHASP ETS_PEA3_N activity, induced transcription, induced 12213813 2 1 0 +BCL2L11 BIM Apoptosis O43521 10018 2q13 human S59-p 454235 GDSCPHGsPQGPLAP molecular association, regulation apoptosis, inhibited beclin 1(INDUCES); LC8(INDUCES) 25526094 7 1 0 anoikis evasion +FLT4 VEGFR3 EC 2.7.10.1; KINASE; Kinase, protein; Membrane protein, integral; Protein kinase, TK; Protein kinase, tyrosine (receptor) P35916 2324 5q35.3 human Y1231-p 4119681 HSLAARYyNWVSFPG molecular association, regulation; enzymatic activity, induced cell motility, induced; cell growth, induced GRB2(INDUCES) 16076871 2 0 1 +SIRT1 SIRT1 Apoptosis; DEACETYLASE; Deacetylase; EC 3.5.1.-; Nuclear receptor co-regulator Q96EB6 23411 10q21.3 human T344-p 25594500 GKLLRNYtQNIDTLE SIR2 molecular association, regulation; acetylation; enzymatic activity, inhibited cell cycle regulation; apoptosis, induced; cytoskeletal reorganization; transcription, induced; signaling pathway regulation DBC-1(DISRUPTS); PLK2(INDUCES) 22728651; 24959379; 30517871 3 2 0 suppress centriole duplication; induces deacetylation of PLK2; regulates p53 acetylation and hence signaling; attenuaties the affinity of SIRT1 for its substrate p53, T344-p promoted apoptosis of HCC cells +Jun Jun Oncoprotein; Transcription factor P05627 16476 4 C5|4 43.34 cM mouse K257-sm 3289001 MESQERIkAERKRMR bZIP_1 molecular association, regulation transcription, inhibited DNA(DISRUPTS) 23396363 2 0 0 +Ptprc CD45 EC 3.1.3.48; Membrane protein, integral; Motility/polarity/chemotaxis; PHOSPHATASE; Receptor protein phosphatase, tyrosine P06800 19264 1 E4|1 60.73 cM mouse S994-p 449974 EPESDESsDDDSDSE Y_phosphatase enzymatic activity, induced 10066810 1 6 0 +Sqstm1 SQSTM1 Autophagy; Nuclear receptor co-regulator; Ubiquitin conjugating system O08623 113894 10q22 rat S348-p 14580829 SSKEVDPsTGELQSL molecular association, regulation KEAP1(INDUCES) 27631370 48 0 1 reduced by LRRK2 overexpression +SDC4 syndecan-4 Cell adhesion; Membrane protein, integral; Motility/polarity/chemotaxis P31431 6385 20q13.12 human S179-p 449863 MKKKDEGsYDLGKKP Syndecan protein stabilization; molecular association, regulation; protein processing; intracellular localization; activity, inhibited; phosphorylation cell cycle regulation; cytoskeletal reorganization; cell adhesion, altered; signaling pathway regulation TIAM1(INDUCES); PKCA(DISRUPTS); syndecan-4(DISRUPTS); PPP3CA(DISRUPTS); Calmodulin(DISRUPTS) Other(DISRUPTS) 12377772; 20229236; 22164265; 29121646; 9748216 11 1 0 Stability of the Rac1-RhoGDI1 complex was increased; binding to lipid increases PKCalpha activation; induces phosphorylation of NFAT, inhibits activity of calcineurin A and NFAT ; S179A mutant abrogates protein shedding ; other = PIP2 binding; decreases PtdIns(4,5)P2 lipid binding +KAT2A GCN5 ACETYLTRANSFERASE; Acetyltransferase; EC 2.3.1.48 Q92830 2648 17q21.2 human T735-p 27421700 KDPDQLYtTLKNLLA acetylation; enzymatic activity, induced transcription, altered 23142079 1 2 0 direct opposition to Sirt1; increases PGC-1a acetylation; Regulates the gluconeogenic transcriptional response of fasted mice +CXCR2 IL8RB GPCR, family 1; Membrane protein, integral; Membrane protein, multi-pass; Receptor, GPCR; Receptor, cytokine P25025 3579 2q35 human S352-p 451048 RPSFVGSsSGHTSTT protein degradation; receptor desensitization, altered; receptor internalization, altered 9079638 1 0 1 +E2f5 E2F5 DNA-binding; Transcription factor Q61502 13559 3|3 A1 mouse T251-p 448010 SQSSTSVtPQKSTMA molecular association, regulation cell cycle regulation; transcription, induced p300(INDUCES) 10783242 1 5 1 +Gphn gephyrin Adaptor/scaffold; EC 2.10.1.1; EC 2.7.7.75 Q03555 64845 6q24 rat S281-p 483463 ASLSTTPsESPRAQA molecular association, regulation neural plasticity gephyrin(DISRUPTS) 23408424; 35307349 5 6 2 regulation of postsynaptic gephyrin cluster size via Calpain degradation +Pard3 PAR3-alpha Adaptor/scaffold; Motility/polarity/chemotaxis Q9Z340 81918 19q12 rat Y1127-p 457508 GHLMDTLyAQVKKPR molecular association, regulation CSK(INDUCES) 35793621 2 25 175 +Ctnnb1 CTNNB1 Actin-binding; Cell adhesion; Motility/polarity/chemotaxis; Nuclear receptor co-regulator; Oncoprotein; Transcription factor Q02248 12387 9 F4|9 72.19 cM mouse Y142-p 449044 AVVNLINyQDDAELA molecular association, regulation cell adhesion, altered CTNNA1(DISRUPTS) 12640114 16 2 0 +Cacna1d CACNA1D Channel, calcium; Membrane protein, integral; Membrane protein, multi-pass P27732 29716 16p16 rat S1534-p 465731 DEFKRIWsEYDPEAK GPHH activity, induced 16763033 1 2 0 required for IGF-1 induced channel potentiation +Dennd1a DENND1A GEF; GEF, Rab; Vesicle Q8K382 227801 2|2 B mouse S536-p 484447 PYRTLKEsDSAEGDE molecular association, regulation 14-3-3 epsilon(INDUCES) 26055712 1 14 1 +ACTB ACTB Cytoskeletal; Motility/polarity/chemotaxis P60709 60 7p22.1 human K326-ac 466094 ALAPSTMkIKIIAPP Actin molecular association, regulation TPM1(DISRUPTS); MYO3B(INDUCES) 32873710 0 5 9 K328 modulates muscle contraction by disrupting inhibitory tropomysin positioning +GYPA GYPA Adaptor/scaffold; Membrane protein, integral P02724 2993 4q31.21 human S38-gl 12726308 TSSSVTKsYISSQTN Glycophorin_A protein conformation 7681597 1 0 0 The structure or conformation of three consecutive Ser/Thr residues may be necessary for its antigenicity. +INCA1 INCA1 Cell cycle regulation Q0VD86 388324 17p13.2 human S191-p 12524603 GRAQLLWsPWSPLDQ molecular association, regulation CCNA1(INDUCES); CCNA2(INDUCES) 15159402 1 0 0 Cyclin A1-CDK2 or Cyclin A2-CDK2 complex +Neurog2 neurogenin 2 Transcription factor P70447 11924 3|3 G2 mouse S234-p 2255100 SCTLSPAsPGSDVDY molecular association, regulation cell growth, altered LDB1(INDUCES) 18400164 2 0 0 important for spinal motor neuron differentiation +Map3k1 MEKK1 EC 2.7.11.25; KINASE; Kinase, protein; Ligase; Protein kinase, STE; Protein kinase, Ser/Thr (non-receptor); UBIQUITIN LIGASE; Ubiquitin conjugating system; Ubiquitin ligase P53349 26401 13 D2.2|13 63.36 cM mouse T280-p 3951974 PFQSGRItPPRRAPS apoptosis, induced 28024901 1 4 1 +H3f3b H3 iso3 DNA-binding P84244 15081 11|11 E2 mouse S10-p 455676 TKQTARKsTGGKAPR Histone activity, induced; molecular association, regulation transcription, induced; transcription, altered; cell growth, altered HP1 alpha(INDUCES) 12578986; 14625384; 15105826; 15994958 241 15 1 +CDCA2 CDCA2 Q69YH5 157313 8p21.2 human S893-p 28698800 SETKVRRsTRLQKDL molecular association, regulation cell cycle regulation H3(DISRUPTS); H2A.1(DISRUPTS) 23746640 1 0 0 +USP10 USP10 DEUBIQUITINASE; EC 3.4.19.12; Protease; RNA-binding; Ubiquitin conjugating system; Ubiquitin-specific protease Q14694 9100 16q24.1 human S76-p 3831744 DTLPRTPsYSISSTL enzymatic activity, induced 26876938 1 3 7 +DKC1 dyskerin EC 5.4.99.-; Isomerase; Lyase; Nucleolus; RNA processing; RNA-binding O60832 1736 Xq28 human K43-sm 31910301 FLIKPESkVAKLDTS protein stabilization 23660516 1 0 0 +RPS6KA3 RSK2 EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, AGC; Protein kinase, Ser/Thr (non-receptor) P51812 6197 Xp22.12 human T115-p 1880515604 KVRDRVRtKMERDIL cell cycle regulation; cell growth, induced 36566564 1 0 0 +CLOCK CLOCK ACETYLTRANSFERASE; Acetyltransferase; DNA-binding; EC 2.3.1.48; Transcription factor O15516 9575 4q12 human T461-p 469131 KIPTDTStPPRQHLP intracellular localization transcription, induced 24235147 1 3 2 regulate nuclear/cytoplasmic localization, Cdk5-mediated increased CLOCK transcription +CNR2 CNR2 GPCR, family 1; Membrane protein, integral; Membrane protein, multi-pass; Receptor, GPCR P34972 1269 1p36.11 human S352-p 450818 KITPWPDsRDLDLSD protein degradation; ubiquitination; receptor desensitization, altered 10400664; 36448459 2 1 0 +Pdc phosducin G protein regulator, misc. P20942 25343 13q21 rat S54-p 454888 KEILRQMsSPQSRDD Phosducin protein stabilization; molecular association, regulation; protein conformation G-gamma 2(DISRUPTS); 14-3-3 zeta(INDUCES); G-beta 1(DISRUPTS) 11331285; 23199924; 25971962; 28402877 5 3 1 slows down the dephosphorylation of pS54 and pS73 +DNER DNER Membrane protein, integral; Receptor, misc. Q8NFT8 92737 2q36.3 human Y718-p 473324 YDVSPIAyEDYSPDD DNER_C intracellular localization 18474614 1 1 4 +Tnni3 TNNI3 Actin-binding; Motility/polarity/chemotaxis; Motor P48787 21954 7 A1|7 2.61 cM mouse S23-p 448423 PAPVRRRsSANYRAY Troponin-I_N activity, induced; activity, inhibited; protein conformation; phosphorylation cytoskeletal reorganization 12923217; 15507454; 15774859; 17010989; 17615373; 20083117; 22527640; 8530519 68 11 11 TNNI3 transgenic and gene transfer of S22/23D showed faster relaxation times. ; ROCK II induced desensitization to Ca++ and depression in maximal tension. +Arhgef15 ephexin-5 GEF; GEF, Rac/Rho Q5FWH6 442801 11|11 B3 mouse Y361-p 17790901 PLQDEPLyQTYRAAV protein degradation; ubiquitination 21029865 1 0 0 +BAG3 BAG3 Apoptosis; Chaperone O95817 9531 10q26.11 human S291-p 467532 STPLHSPsPIRVHTV protein degradation neural plasticity 31955914 2 40 27 +LDHA LDH-A Amino Acid Metabolism - cysteine and methionine; Apoptosis; Carbohydrate Metabolism - glycolysis and gluconeogenesis; Carbohydrate Metabolism - propanoate; Carbohydrate Metabolism - pyruvate; EC 1.1.1.27; Oxidoreductase P00338 3939 11p15.1 human K5-ac 461532 ___MATLkDQLIYNL protein degradation; molecular association, regulation; enzymatic activity, inhibited carcinogenesis, inhibited; autophagy, induced; cell growth, inhibited; cell motility, inhibited HSC70(INDUCES) 23523103 1 5 78 +GRK2 GRK2 EC 2.7.11.15; KINASE; Kinase, protein; Protein kinase, AGC; Protein kinase, Ser/Thr (non-receptor) P25098 156 11q13.2 human S685-p 447726 VPLVQRGsANGL___ molecular association, regulation G-alpha(q)(INDUCES) 16885398 3 11 1 +Kcnk10 TREK-2 Channel, potassium; Membrane protein, integral; Membrane protein, multi-pass Q9JIS4 65272 6q32 rat S359-p 465530 RETRRRLsVEIHDKL activity, inhibited 16672694; 17540699 2 1 0 relative channel activity reduced in S326D and S359D mutants; shift of gating modes; inhibition mediated by ACh +INCENP INCENP Cell cycle regulation; EC 2.7.11.1 Q9NQS7 3619 11q12.3 human T892-p 450466 KPRYHKRtSSAVWNS activity, induced; protein stabilization; molecular association, regulation; enzymatic activity, induced INCENP(INDUCES) 12925766; 27332895 2 6 3 +SCRIB Scribble Cell adhesion; Motility/polarity/chemotaxis Q14160 23513 8q24.3 human S1378-p 470678 EGPPKRVsLVGADDL intracellular localization cell motility, induced; cell adhesion, induced 33583073 2 50 82 +Mertk Mer EC 2.7.10.1; KINASE; Kinase, protein; Membrane protein, integral; Oncoprotein; Protein kinase, TK; Protein kinase, tyrosine (receptor) Q60805 17289 2|2 F1 mouse Y867-p 1319200 QDKESIIyINTQLLE phosphorylation exocytosis, altered 18039660 1 0 0 regulates phagocytosis and Y861 phosphorylation of FAK, and Akt activation +Cdkn1b p27Kip1 Cell cycle regulation; Inhibitor; Oncoprotein; Protein kinase, regulatory subunit P46414 12576 6 G1|6 65.77 cM mouse Y88-p 456818 RGSLPEFyYRPPRPP molecular association, regulation CK2A1(DISRUPTS) 28295363 14 0 0 +NR1I3 NR1I3 DNA-binding; Nuclear receptor Q14994 9970 1q23.3 human T38-p 11281700 CKGFFRRtVSKSIGP zf-C4 molecular association, regulation; intracellular localization; protein conformation; activity, inhibited transcription, induced; transcription, inhibited; signaling pathway regulation ERK2(INDUCES); RACK1(INDUCES); ERK1(INDUCES); NR1I3(INDUCES); RXRA(DISRUPTS) DNA(DISRUPTS) 19858220; 21873423; 23652203; 24252946; 28265001; 29133527 6 0 0 homodimerization +PTEN PTEN Carbohydrate Metabolism - inositol phosphate; EC 3.1.3.16; EC 3.1.3.48; EC 3.1.3.67; Motility/polarity/chemotaxis; Nuclear receptor co-regulator; PHOSPHATASE; Phosphatase, lipid; Tumor suppressor P60484 5728 10q23.31 human Y336-p 7596704 NKDKANRyFSPNFKV PTEN_C2 protein stabilization; molecular association, regulation NEDD4 iso4(DISRUPTS) 19345329 2 0 0 +CD6 CD6 Cell surface; Membrane protein, integral P30203 923 11q12.2 human S505-p 15402653 ALTTFYNsQRHRVTD phosphorylation signaling pathway regulation 23711376 1 0 0 ERK1/2 phosphorylation, MAPK pathway activation +BRAF BRAF EC 2.7.11.1; KINASE; Kinase, protein; Oncoprotein; Protein kinase, Ser/Thr (non-receptor); Protein kinase, TKL P15056 673 7q34 human S750-p 2192591 FSLYACAsPKTPIQA molecular association, regulation cell growth, altered RAF1(DISRUPTS) 19933846 2 12 3 +Foxa2 FOXA2 DNA-binding; Transcription factor P32182 rat K6-sm 27852600 __MLGAVkMEGHEPS protein stabilization transcription, induced 23118920 1 0 0 +RGS7 RGS7 GAP; GAP, RGS P49802 6000 1q43|1q23.1 human S434-p 455540 YKLMKSDsYPRFIRS RGS molecular association, regulation 14-3-3 beta(DISRUPTS) 12077120 1 0 0 +CEP131 CEP131 Calcium-binding Q9UPN4 22994 17q25.3 human T205-p 1868722300 PLKSSNQtAPSLNNI molecular association, regulation; intracellular localization carcinogenesis, induced; cytoskeletal reorganization; signaling pathway regulation STIL(INDUCES) 31358734 1 1 0 interaction with STIL promotes STIL relocation to the centrioles +DVL3 DVL3 Motility/polarity/chemotaxis Q92997 1857 3q27.1 human S636-p 34668132 ASEHSHRsHHSLASS Dsh_C intracellular localization 24993822 1 1 0 +DAZL DAZL Translation Q92904 1618 3p24.3 human S65-p 31908003 SFFARYGsVKEVKII RRM_1 molecular association, regulation translation, inhibited PABP 1(DISRUPTS) 27280388 1 1 0 negative regulator of male meiosis +POU5F1 Oct4 DNA-binding; Transcription factor Q01860 5460 6p21.33 human K156-ub 57951800 FAKLLKQkRITLGYT Pou protein stabilization; molecular association, regulation transcription, induced SOX2(INDUCES) 27369080 1 1 0 +SMURF1 SMURF1 EC 6.3.2.-; EC 6.3.2.19; Ligase; UBIQUITIN LIGASE; Ubiquitin conjugating system; Ubiquitin ligase Q9HCE7 57154 7q22.1 human T332-p 18156100 VDHNNRTtQFTDPRL WW protein stabilization 28581524 2 0 0 +Klf10 KLF10 C2H2-type zinc finger protein; DNA-binding; Transcription factor O89091 21847 15|15 B3.1 mouse T188-p 25743268 DNSFRRRtHGNVEAT protein stabilization; molecular association, regulation transcription, inhibited DNA(INDUCES) 34869587 1 0 1 +SUPT5H SPT5 RNA-binding; Transcription, coactivator/corepressor O00267 6829 19q13.2 human S773-p 15415344 GRTPMYGsQTPMYGS transcription, induced 10757782 1 1 6 +SDC1 syndecan-1 Extracellular matrix; Membrane protein, integral; Motility/polarity/chemotaxis P18827 6382 2p24.1 human Y309-p 455075 PTKQEEFyA______ molecular association, regulation cytoskeletal reorganization; cell adhesion, altered syntenin(DISRUPTS) 19228696 2 9 162 required for LG4/5-induced microspikes +CACNA1B CACNA1B Channel, calcium; Membrane protein, integral; Membrane protein, multi-pass Q05152 100008979 rabbit S447-p 459048 TGLCAPGsPFARASL activity, induced 16406008 1 1 4 +Creb1 CREB DNA-binding; Transcription factor Q01147 12912 1 C2|1 32.74 cM mouse Y120-p 15409156 ILSRRPSyRKILNDL pKID phosphorylation neural plasticity; transcription, inhibited 32776935; 32878981 4 0 4 increase 119 phosphorylation by Y120F mutant +PYGM PYGM Carbohydrate Metabolism - starch and sucrose; EC 2.4.1.1; Endoplasmic reticulum; Phosphorylase; Transferase P11217 5837 11q13.1 human S15-p 449838 QEKRKQIsVRGLAGV protein conformation; enzymatic activity, induced 1150650 5 7 1 14 residue phosphopeptide with phosphorylated S14, PYGM becomes activated in the absence of AMP and associates to a tetramer. +WEE1 Wee1 EC 2.7.10.2; KINASE; Kinase, protein; Protein kinase, Other; Protein kinase, Ser/Thr (non-receptor); Protein kinase, tyrosine (non-receptor) P30291 7465 11p15.4 human T239-p 11311200 QVNINPFtPDSLLLH enzymatic activity, inhibited; phosphorylation cell cycle regulation 19858290; 25744022 2 0 0 Inhibits CDK1 phosphorylation and prevents SAC slippage +ATM ATM DNA repair, damage; EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, Ser/Thr (non-receptor); Protein kinase, atypical; Tumor suppressor Q13315 472 11q22.3 human S1981-p 448797 SLAFEEGsQSTTISS activity, induced; protein stabilization; molecular association, regulation; enzymatic activity, inhibited; intracellular localization; phosphorylation; enzymatic activity, induced cell cycle regulation; carcinogenesis, induced; apoptosis, altered; carcinogenesis, altered; carcinogenesis, inhibited; apoptosis, induced; transcription, altered; signaling pathway regulation; DNA repair, induced; autophagy, induced; cell growth, induced; chromatin organization, altered; apoptosis, inhibited; DNA repair, altered PKM(INDUCES); p53(INDUCES); H2AX(INDUCES); CDCA2(DISRUPTS); BUB1B(INDUCES); ATM(INDUCES); MDC1(INDUCES); NBS1(INDUCES); NKX3-1(INDUCES) DNA(INDUCES) 12556884; 14695167; 15048089; 15173573; 15269203; 15964794; 16141325; 16478990; 17486112; 17940005; 18449195; 18560558; 18571408; 18987440; 19071136; 20026654; 20188555; 20372057; 20637859; 22099307; 23365634; 23708966; 23890999; 24876101; 25299772; 25355892; 25775545; 26586426; 27810895; 31980741; 32075772; 32203529; 33512436; 33857133; 34482636; 34545188; 34604061; 34676045; 35045984; 35353542; 35513056; 35798878; 36065181; 36273494; 36692427 214 24 4 +CTNND1 CTNND1 Actin-binding; Adaptor/scaffold; Cell adhesion; G protein regulator, misc.; Motility/polarity/chemotaxis O60716 1500 11q12.1 human S269-p 470326 QVRVGGSsVDLHRFH activity, induced; protein stabilization; molecular association, regulation endocytosis, induced; transcription, induced CDH2(DISRUPTS); LRP5(DISRUPTS); LRP6(DISRUPTS) 24412065 2 54 8 GSK3, Axin, Dvl-2 internalization induced, stabilization and transcriptional activity of CTNNB1 induced +AQP4 AQP4 iso4 Channel, misc.; Membrane protein, integral; Membrane protein, multi-pass; Transporter; Transporter, aquaporin family A0A5F9ZHR4 361 18q11.2 human S335-p 1877492101 RTESRQDsLELSSDF intracellular localization 35625560 1 0 0 +NFKBIA IkB-alpha DNA-binding; Inhibitor P25963 4792 14q13.2 human S63-p 1873119300 PQEVPRGsEPWKQQL phosphorylation carcinogenesis, induced; cell growth, induced; apoptosis, inhibited; transcription, induced 34030642 1 1 0 induce p65 trancsription activity; inhibits phosphorylation of RIP3 and MLKL +CREB1 CREB DNA-binding; Transcription factor P16220 1385 2q33.3 human K122-ac 459099 SRRPSYRkILNDLSS pKID molecular association, regulation transcription, induced p300(INDUCES); CBP(INDUCES) 25404345 4 0 0 +ARHGDIA RhoGDI alpha Apoptosis; Cell adhesion; Cell development/differentiation; G protein regulator, misc.; Motility/polarity/chemotaxis P52565 396 17q25.3 human Y156-p 469606 YGPRAEEyEFLTPVE Rho_GDI molecular association, regulation; enzymatic activity, inhibited; intracellular localization carcinogenesis, induced; cell motility, induced RHOA(DISRUPTS); RAC1(DISRUPTS); CDC42 iso1(DISRUPTS) 16943322; 20028975; 32003021; 34532864 4 2 22 +Prkcd PKCD EC 2.7.11.13; KINASE; Kinase, protein; Nuclear receptor co-regulator; Protein kinase, AGC; Protein kinase, Ser/Thr (non-receptor); Protein kinase, tyrosine (non-receptor); Tumor suppressor P09215 170538 16p16 rat T141-p 1028305 EEEAMFPtMNRRGAI phosphorylation; enzymatic activity, induced 26546672 2 9 1 downregulates phosphorylation of S357 +Zbtb17 ZBTB17 C2H2-type zinc finger protein; DNA-binding; Transcription factor Q60821 22642 4|4 D3 mouse S178-p 5881622 GQAESASsGAEQTEK molecular association, regulation DNA(INDUCES) 23525087 1 1 1 inhibits recruitment of HDAC1 to Cebpd promoter, suppression of inflammation +Vim Vimentin Cytoskeletal; Motility/polarity/chemotaxis P20152 22352 2 A1|2 10.04 cM mouse S66-p 451765 GAYVTRSsAVRLRSS Filament_head cytoskeletal reorganization 12458200 5 11 20 +SQSTM1 SQSTM1 Autophagy; Nuclear receptor co-regulator; Ubiquitin conjugating system Q13501 8878 5q35.3 human K91-ub 15398061 TMAMSYVkDDIFRIY PB1 autophagy, induced 27880896 1 0 32 antibacterial autophagy +Pak1 PAK1 EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, STE; Protein kinase, Ser/Thr (non-receptor) P35465 29431 1q32 rat T211-p 448176 VIEPLPVtPTRDVAT intracellular localization cytoskeletal reorganization 12176334 17 27 19 during mitosis +MYC Myc DNA-binding; Nucleolus; Oncoprotein; Transcription factor P01106 4609 8q24.21 human S77-p 448586 LLPTPPLsPSRRSGL Myc_N O-GlcNAc glycosylation; protein degradation; molecular association, regulation; protein stabilization; phosphorylation; activity, induced; ubiquitination; intracellular localization cell cycle regulation; carcinogenesis, induced; apoptosis, altered; apoptosis, induced; transcription, induced; transcription, altered; cell growth, induced; chromatin organization, altered; apoptosis, inhibited; cell growth, altered FBXW7(INDUCES); SH2BP1(INDUCES); OTUD6A(INDUCES); CDC73(INDUCES); AurA(INDUCES); PIN1(INDUCES); RNF4(INDUCES); axin 1(INDUCES); PPP2R5A(NOT_REPORTED); CIP2A(INDUCES) DNA(INDUCES) 10551811; 11018017; 11243879; 11904304; 15103331; 15150404; 16483932; 16537924; 17634226; 18408012; 19028839; 19131971; 20140016; 21808024; 22025562; 23318434; 23716601; 25006129; 25438055; 25893300; 25944903; 26235622; 26687678; 27002159; 27213815; 27239040; 27653698; 33552953; 33627622; 33854232; 33928666; 34192548; 34289988; 34758313; 35039060; 35089787; 35217790; 36012403; 37408910; 37656618; 8386367 86 38 33 +MET Met EC 2.7.10.1; KINASE; Kinase, protein; Membrane protein, integral; Oncoprotein; Protein kinase, TK; Protein kinase, tyrosine (receptor) P08581 4233 7q31.2 human Y1234-p 448470 RDMYDKEyYSVHNKT PK_Tyr_Ser-Thr activity, induced; protein conformation; phosphorylation; enzymatic activity, induced carcinogenesis, induced; cell motility, induced; cell motility, altered; apoptosis, inhibited; signaling pathway regulation; cell growth, altered GRB2(INDUCES); PTP1B(INDUCES); PTPN2(INDUCES) 10490849; 12746450; 14559966; 18819921; 21247903; 21918175; 22081023; 24634221; 27147579; 7961992; 8302603 57 36 740 +F2RL1 F2RL1 GPCR, family 1; Membrane protein, integral; Membrane protein, multi-pass; Receptor, GPCR P55085 2150 5q13.3 human S390-p 22350016 SSSYSSSsTTVKTSY receptor desensitization, induced; molecular association, regulation; phosphorylation signaling pathway regulation ARRB1(INDUCES); ARRB2(INDUCES) 33073187 1 1 0 inhibits ERK phosphorylation and signaling; regulates calcium signaling +Becn1 beclin 1 Adaptor/scaffold; Autophagy; Membrane protein, peripheral O88597 56208 11|11 D mouse S29-p 7446159 QPLKLDTsFKILDRV protein degradation; intracellular localization endocytosis, induced; cytoskeletal reorganization; signaling pathway regulation 33775979 5 6 0 PGK1-beclin1 pathway regulation; regulates AcLDL localization and degradation +Ctnnd2 CTNND2 Actin-binding; Motility/polarity/chemotaxis O35927 18163 15|15 B2 mouse Y1176-p 461085 QEPSRKDyETYQPFP protein stabilization; molecular association, regulation cell cycle regulation; cell motility, altered GSK3B(DISRUPTS) 18515860; 24412473 1 2 2 +Panx1 PANX1 Cell adhesion; Membrane protein, integral; Membrane protein, multi-pass P60570 315435 8q12 rat Y308-p 54421200 KTDVLKVyEILPTFD activity, induced apoptosis, induced 26854804 3 0 0 NMDAR-Src-Panx1 signaling +FOXO3 FOXO3A Autophagy; DNA-binding; Oncoprotein; Transcription factor O43524 2309 6q21 human S555-p 20799903 RALSNSVsNMGLSES phosphorylation transcription, induced 17711846 2 1 0 induces phosphorylation of other sites +HMGN1 HMGN1 DNA-binding; Nuclear receptor co-regulator P05114 3150 21q22.2 human S25-p 454112 KRRSARLsAKPPAKV HMG14_17 molecular association, regulation; intracellular localization transcription, altered 14-3-3 zeta(INDUCES); SRF(DISRUPTS) DNA(DISRUPTS) 10739259; 12215538; 17938209 5 12 0 +NCF4 p40phox Oxidoreductase Q15080 4689 22q12.3 human T154-p 448266 LRRLRPRtRKVKSVS enzymatic activity, induced 34264265 5 0 0 +Sox4 SOX4 DNA-binding; Transcription factor Q06831 20677 13 A3.1|13 12.87 cM mouse S316-p 41454646 GRSSAASsPAASRSP protein degradation cell differentiation, induced 34431536 1 3 0 +SOD2 SOD2 EC 1.15.1.1; Mitochondrial; Oxidoreductase P04179 6648 6q25.3 human S106-p 7577901 SIFWTNLsPNGGGEP Sod_Fe_N protein stabilization; enzymatic activity, induced apoptosis, inhibited 23243068; 25578653 4 1 0 mitochondrial apoptosis +RPL11 RPL11 Motility/polarity/chemotaxis; Nucleolus; Ribosomal; Translation P62913 6135 1p36.11 human K85-ne 12067603 KAEEILEkGLKVREY Ribosomal_L5_C protein stabilization; intracellular localization 19713960 1 0 0 +NBN NBS1 Cell cycle regulation; DNA repair, damage O60934 4683 8q21.3 human K208-ac 487507 DEPSIGSkNVDLSGR phosphorylation cell cycle regulation; apoptosis, induced; DNA repair, inhibited 17612497; 28869605 3 1 0 +Usp8 USP8 DEUBIQUITINASE; EC 3.4.19.12; Protease; Ubiquitin conjugating system; Ubiquitin-specific protease Q80U87 84092 2|2 F1 mouse S680-p 454338 SKLKRSYsSPDITQA molecular association, regulation 14-3-3 beta(INDUCES); 14-3-3 epsilon(INDUCES) 16944949; 23333852 4 71 26 +CYCS CYCS Apoptosis; Mitochondrial; Oxidoreductase; PHOSPHATASE; Protein phosphatase, Ser/Thr (non-receptor) P62894 510767 cow Y49-p 473243 GQAPGFSyTDANKNK Cytochrom_C activity, inhibited signaling pathway regulation 18471988; 20586425; 21771582 4 4 4 inhibits mitochondrial prespiration; regualtion of electron transport chain; Y48E mutation decreases CYCS redox potential +Oprm1 MOR-1 GPCR, family 1; Membrane protein, integral; Membrane protein, multi-pass; Receptor, GPCR P33535 25601 1q11 rat S355-p 3063302 REFCIPTsSTIEQQN receptor desensitization, altered; phosphorylation 12123746 1 0 0 +CHMP7 CHMP7 Q8WUX9 91782 8p21.3 human S3-p 54367850 _____MWsPEREAEA molecular association, regulation cell cycle regulation CHMP7(DISRUPTS); LEMD2(DISRUPTS) 34286694 1 1 0 +Bach1 BACH1 DNA-binding; Transcription factor P97302 12013 16|16 C3.3 mouse Y486-p 11498503 LEIGNYDyVSEPQQE molecular association, regulation; intracellular localization transcription, altered Exportin-1(INDUCES) 19897490 1 0 0 +SIRT1 SIRT1 Apoptosis; DEACETYLASE; Deacetylase; EC 3.5.1.-; Nuclear receptor co-regulator Q96EB6 23411 10q21.3 human S669-p 1874020212 EDDVLSSsSCGSNSD molecular association, regulation; acetylation; protein conformation; enzymatic activity, induced transcription, induced p53(INDUCES); DBC1(DISRUPTS) 34216621 1 1 0 inhibits PGC-1a deacetylation +Map2 MAP2 iso3 Cytoskeletal; Motility/polarity/chemotaxis P15146-3 25595 9q32 rat K401-ac 62495509 NVKIDSQkLNFREHA cytoskeletal reorganization 28002468 1 1 0 +LAT2 LAB Adaptor/scaffold; Membrane protein, integral Q9GZY6 7462 7q11.23 human Y136-p 450963 EDDDANSyENVLICK LAT2 molecular association, regulation cell differentiation, altered GRB2(INDUCES) 14722116 3 10 169 +OSMR OSMR Membrane protein, integral; Receptor, cytokine Q99650 9180 5p13.1 human Y837-p 462479 TELTKPNyLYLLPTE phosphorylation 18430728 2 5 19 important for STAT5B activation +MBP MBP Cytoskeletal P02687 618684 cow R106-m1 475947 PPSQGKGrGLSLSRF Myelin_MBP protein conformation 5128665 3 2 8 +CDKN1A p21Cip1 Cell cycle regulation; Inhibitor P38936 1026 6p21.2 human K141-ac 12615905 PGDSQGRkRRQTSMT protein stabilization; molecular association, regulation cell cycle regulation; carcinogenesis, inhibited; cell growth, inhibited C8A(DISRUPTS) 20154723 1 0 0 +WASF2 WAVE2 Actin-binding; Motility/polarity/chemotaxis Q9Y6W5 10163 1p36.11 human S488-p 6377641 YSDSEDDsSEFDEDD activity, inhibited cytoskeletal reorganization 19012317 1 0 1 +RHOA RHOA G protein; G protein, monomeric; G protein, monomeric, Rho; Motility/polarity/chemotaxis; Oncoprotein P61586 387 3p21.31 human Y66-p 475231 DTAGQEDyDRLRPLS Ras molecular association, regulation; activity, inhibited cytoskeletal reorganization; signaling pathway regulation PKN1(DISRUPTS); PKN2(DISRUPTS); Diaphanous-1(DISRUPTS); RTKN(DISRUPTS); ROCK2(DISRUPTS); DAAM1(DISRUPTS); ROCK1(DISRUPTS) 23027962 1 3 12 phosphorylation of this site inhibits binding of RhoA to cellular effectors; phosphorylation of this site inhibits F-actin formation +MTOR mTOR Autophagy; EC 2.7.11.1; KINASE; Kinase, protein; Motility/polarity/chemotaxis; Protein kinase, Ser/Thr (non-receptor); Protein kinase, atypical P42345 2475 1p36.22 human T631-p 59070502 RTCSRLLtPSIHLIS protein degradation; ubiquitination 27746162 1 0 0 +Pdgfra PDGFRA EC 2.7.10.1; KINASE; Kinase, protein; Membrane protein, integral; Oncoprotein; Protein kinase, TK; Protein kinase, tyrosine (receptor) P20786 25267 14p11 rat Y848-p 448441 DIMHDSNyVSKGSTF PK_Tyr_Ser-Thr cell motility, induced; cell growth, induced 34858182 8 9 59 +BECN1 beclin 1 Adaptor/scaffold; Autophagy; Membrane protein, peripheral Q14457 8678 17q21.31 human S15-p 25268704 NNSTMQVsFVCQRCS intracellular localization autophagy, induced 26118643; 35443161; 36719945 11 1 0 induces mitophagy +YWHAG 14-3-3 gamma Adaptor/scaffold P61981 7532 7q11.23 human S59-p 3892745 VVGARRSsWRVISSI 14-3-3 molecular association, regulation; intracellular localization TNRC6A(INDUCES) 21118956 2 0 8 localizes to P-bodies +Hnrnpk hnRNP K RNA splicing; RNA-binding; Spliceosome P61979 15387 13|13 B1 mouse S302-p 457408 GRGGRGGsRARNLPL molecular association, regulation translation, induced RNA(INDUCES) 17581920 4 0 0 +Cdk5rap2 CDK5RAP2 Cytoskeletal Q8K389 214444 4|4 C2 mouse S608-p 41285495 KALQEQLsEIRSREE cell cycle regulation 29282278 1 1 0 PLK1-dependent CDK5RAP2 phosphorylation at S608 leads to increased chromosome instability through the formation of lagging chromosomes and formation of micronuclei. +YAF2 YAF2 Transcription, coactivator/corepressor Q8IY57 10138 12q12 human S167-p 3205731 RGMSRSSsPRGEASS protein stabilization carcinogenesis, induced; apoptosis, inhibited 33784512 2 24 2 induces FANK1 stabilization +ASL ASL Amino Acid Metabolism - alanine, aspartate and glutamate; Amino Acid Metabolism - arginine and proline; EC 4.3.2.1; Endoplasmic reticulum; Lyase; Mitochondrial P04424 435 7q11.21 human K288-ac 27614500 SSLMPQKkNPDSLEL Lyase_1 enzymatic activity, inhibited 20167786 0 2 0 +Sh3gl2 endophilin A1 Adaptor/scaffold; Membrane protein, peripheral; Vesicle O35179 116743 rat S75-p 33402207 LSMINTMsKIRGQEK BAR endocytosis, altered 24778241 1 0 0 Vesicle and membrane formation. Phosphomimetic modification at S75 inhibits stable tubulation by shifting the insert region to shallower depths within the lipid bilayer. +UBA52-RPS27A-UBB-UBC ubiquitin Ubiquitin-like modifier P62988 2p16 human K6-ac 459084 __MQIFVkTLTGKTI ubiquitin protein degradation; molecular association, regulation; ubiquitination UBE2V1(INDUCES) 15790562; 25527407 5 7 6 inhibits polyubiquitin chain elongation +NHERF4 PDZD3 Cell adhesion Q86UT5 79849 11q23.3 human S395-p 25546601 LGHEETVsRIQGQGS PDZ molecular association, regulation SLC26A3(INDUCES) 22627094 1 0 0 +BBC3 PUMA Apoptosis; Mitochondrial Q9BXH1 27113 19q13.32 human S10-p 18610000 RARQEGSsPEPVEGL PUMA protein degradation; molecular association, regulation; ubiquitination carcinogenesis, induced; cell growth, induced; apoptosis, inhibited FBXL20(INDUCES) 21364664; 21997190; 34587475 3 11 0 +Slc1a2 GLT1 Membrane protein, integral; Membrane protein, multi-pass; Transporter; Transporter, SLC family P31596 29482 3q32 rat Y403-p 3064900 NMDGTALyEAVAAIF SDF activity, induced 12384259 1 0 0 Y403H mutant sensitive to volatile anesthetics +Hspa8 HSC70 Chaperone; Heat shock protein; Nucleolus; RNA-binding P63017 15481 9 A5.1|9 21.55 cM mouse S85-p 31857927 FDDAVVQsDMKHWPF HSP70 molecular association, regulation autophagy, induced PKM iso2(INDUCES); APP(INDUCES); HK2(INDUCES) 34291435 1 7 0 +Gli1 GLI1 C2H2-type zinc finger protein; Oncoprotein; Transcription factor P47806 14632 10 D3|10 74.5 cM mouse S481-p 1412327901 GGSTEDLsSLDEGPC molecular association, regulation; intracellular localization cell cycle regulation; transcription, inhibited; signaling pathway regulation SUFU(INDUCES) 30578313 1 1 0 Hedgehog (Hh) signaling reduced by phosphorylation +DDB2 DDB2 DNA repair, damage Q92466 1643 11p11.2 human K77-ub 1876931105 VRTLHQHkLGRASWP DNA repair, induced 32789493 1 1 0 SIRT6 as a critical factor in the regulation of the process of UV-induced DNA damage repair +Cdc7 CDC7 EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, Other; Protein kinase, Ser/Thr (non-receptor) Q9Z0H0 12545 5|5 E5 mouse T367-p 2864203 QVAPRAGtPGFRAPE Pkinase enzymatic activity, induced cell growth, induced; cell differentiation, induced; transcription, induced; cytoskeletal reorganization 22223649 3 1 12 +CENPQ CENPQ Q7L2Z9 55166 6p12.3 human T135-p 40245505 PKKMEDLtNVSSLLN CENP-Q molecular association, regulation; intracellular localization DNA(DISRUPTS) 25670858 1 1 0 CENPQ phosphorylation promotes the delocalization of the PBIP1-CENPQ complex from kinetochores +Cnp CNP Cell development/differentiation; EC 3.1.4.37; Phosphodiesterase P13233 25275 10q31 rat K150-ac 1881330702 QVVLVEPkTAWRLDC enzymatic activity, inhibited; protein conformation 34330062 1 1 0 +H3c1 H3 DNA-binding P68433 360198 13|13 A3.1 mouse K36-m2 1458610 APATGGVkKPHRYRP Histone transcription, inhibited 20561915 44 18 7 +ZBTB25 ZBTB25 C2H2-type zinc finger protein P24278 7597 14q23.3 human K204-sm 1873596000 QKPPVSIkQERCDPE molecular association, regulation transcription, induced RNA(INDUCES) 28768860 1 0 0 IAV RNA binding and promotion of viral transcription and/or replication +Pou5f1 Oct4 DNA-binding; Transcription factor P20263 18999 17 B1|17 18.69 cM mouse S347-p 25236701 VPVTALGsPMHSN__ protein degradation; ubiquitination cell differentiation, induced; transcription, inhibited 29153991 2 3 0 improve the reprogramming efficiency of SKH-1 MEFs +Nfkbib IkB-beta Inhibitor Q60778 18036 7|7 B1 mouse S313-p 452013 DKLSPCSsSGSDSDS apoptosis, induced; autophagy, inhibited 27508931 4 0 0 Hypo-phosphorylated S313 is beneficial to the heart in sepsis through inhibition of apoptosis and enhancement of autophagy in mutated I?B? transgenic mice. +Nedd4l NEDD4L EC 6.3.2.-; EC 6.3.2.19; Ligase; UBIQUITIN LIGASE; Ubiquitin conjugating system; Ubiquitin ligase Q8CFI0 83814 18|18 E1 mouse T396-p 453439 TRRARSStVTGGEEP molecular association, regulation; intracellular localization 14-3-3 epsilon(INDUCES) 21900244 5 3 15 +Slc23a2 SLC23A2 Membrane protein, integral; Membrane protein, multi-pass; Transporter; Transporter, SLC family Q9EPR4 54338 2|2 F2 mouse S640-p 483980 KSENSRSsDKDSQAT intracellular localization cell differentiation, altered 17585336 1 0 0 Phosphorylation is required for SLC3A2 localization in plasma membrane, and ascorbic acid uptake. +HMGB1 HMGB1 DNA repair, damage; Nuclear receptor co-regulator P09429 3146 13q12.3 human S181-p 20506700 GVVKAEKsKKKKEEE intracellular localization 22750245 3 0 0 +DDR1 DDR1 EC 2.7.10.1; KINASE; Kinase, protein; Membrane protein, integral; Protein kinase, TK; Protein kinase, tyrosine (receptor) Q08345 780 6p21.33 human Y513-p 457956 LLLSNPAyRLLLATY activity, induced; molecular association, regulation SHC1(INDUCES) 24509848; 27605668; 9659899 3 9 335 +Map3k11 MLK3 EC 2.7.11.25; KINASE; Kinase, protein; Protein kinase, Ser/Thr (non-receptor); Protein kinase, TKL Q80XI6 26403 19 A|19 4.34 cM mouse S282-p 448262 WHKTTQMsAAGTYAW PK_Tyr_Ser-Thr enzymatic activity, induced 34324442 8 0 0 +NFATC3 NFAT4 DNA-binding; Transcription factor Q12968 4775 16q22.1 human S207-p 11507602 AARFTLGsPLTSPGG intracellular localization 9630228 1 2 1 cytoplasmic localization (inhibition of nuclear localization) +GIT2 GIT2 GAP; GAP, ARF; Motility/polarity/chemotaxis Q9Y621 374035 chicken Y592-p 450866 SSVPESDyDNTTASL molecular association, regulation; intracellular localization cell adhesion, altered PXN(INDUCES) 16000375 1 13 222 +KALRN kalirin EC 2.7.11.1; GEF; GEF, Rac/Rho; KINASE; Kinase, protein; Protein kinase, CAMK; Protein kinase, Ser/Thr (non-receptor) O60229 8997 3q21.1-q21.2 human T95-p 1315601 DVCKRGFtVIIDMRG CRAL_TRIO_2 activity, induced 26858404 2 0 0 enhancement of AMPAR-mediated synaptic transmission, LTP induction +DRD2 DRD2 iso2 GPCR, family 1; Membrane protein, integral; Membrane protein, multi-pass; Receptor, GPCR P14416-2 1813 11q23.2 human T225-p 13270200 RRRKRVNtKRSSRAF 7tm_1 receptor desensitization, induced; receptor recycling, induced 23082996 2 0 0 PKC mediated receptor desensitization and internalization +LRP6 LRP6 Membrane protein, integral; Receptor, misc. O75581 4040 12p13.2 human T1572-p 3802448 EPVPPPPtPRSQYLS activity, induced; molecular association, regulation transcription, induced; signaling pathway regulation axin 1(INDUCES) 21887268; 22558232; 25500543 5 0 8 Wnt-beta-catenin signaling; increased B-catennin/TCF4 activity; Regulation of Wnt pathway +TBK1 TBK1 EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, Other; Protein kinase, Ser/Thr (non-receptor) Q9UHD2 29110 12q14.2 human K69-ub 27492601 LNHKNIVkLFAIEEE Pkinase molecular association, regulation; enzymatic activity, induced transcription, induced; signaling pathway regulation IKKG(INDUCES) 23028469 1 2 0 RIG-I-mediated antiviral defense and IFN-activation signaling +ECD SGT1 Transcription, coactivator/corepressor O95905 11319 10q22.2 human S518-p 3178827 EDFECLDsDDDLDFE SGT1 cell cycle regulation 26711270 2 7 0 +TAF7 TAF7 DNA-binding; Transcription, coactivator/corepressor Q15545 6879 5q31.3 human S264-p 468898 LQDKLNEsDEQHQEN molecular association, regulation; acetylation cell cycle regulation; transcription, induced DNA(DISRUPTS) 22711989 1 35 0 +KCNMA1 KCNMA1 Channel, potassium; Endoplasmic reticulum; Membrane protein, integral; Membrane protein, multi-pass Q28265 403984 dog S1084-p 466425 QSSSKKSsSVHSIPS activity, induced 10196172 2 0 0 increases open probability of channel +GLI1 GLI1 C2H2-type zinc finger protein; Oncoprotein; Transcription factor P08151 2735 12q13.3 human S968-p 1034327201 SGSYPTPsPCHENFV molecular association, regulation; intracellular localization transcription, inhibited SUFU(INDUCES) DNA(DISRUPTS) 29662197 1 0 0 localized in cytoplasm +ESR1 ER-alpha DNA-binding; Nuclear receptor; Transcription factor P03372 2099 6q25.1-q25.2 human K268-ac 461006 GGRMLKHkRQRDDGE activity, induced; protein stabilization; molecular association, regulation cell growth, inhibited; transcription, induced; cell motility, inhibited; transcription, altered DNA(INDUCES) 16497729; 19887647; 33544437 4 1 0 MOF depletion promotes proliferation, motility and invasion in HCC; K266/268Q or K266/268R mutations confer resistance to repression by BRCA1 +ANXA7 ANXA7 Calcium-binding; Lipid-binding; Motility/polarity/chemotaxis P20073 310 10q22.2 human T286-p 18908667 VLIEILCtRTNQEIR Annexin molecular association, regulation; intracellular localization ITGB4(INDUCES) 23651924; 26918348 3 1 0 +LEPR LEPR Membrane protein, integral; Receptor, cytokine P48357 3953 1p31.3 human Y986-p 448435 QRQPFVKyATLISNS translation, induced 17726024 16 0 0 cap-dependent translation +Myb Myb DNA-binding; Oncoprotein; Transcription factor P06876 17863 10 A3|10 9.75 cM mouse S528-p 453087 KIKQEVEsPTEKSGN Cmyb_C activity, induced; molecular association, regulation; activity, inhibited transcription, inhibited PIN1(INDUCES) 17077080; 18359295; 8798443 5 11 1 slight increase in conjugation of two and three molecules of SUMO-2 with S528A phospho-mutant under stress; S528 phosphorylation negatively regulates transcription transactivating activity of Myb. +Irs2 IRS2 Adaptor/scaffold; Motility/polarity/chemotaxis P81122 384783 8 A1.1|8 5.35 cM mouse Y671-p 454968 NSCKSDDyMPMSPTS molecular association, regulation; phosphorylation signaling pathway regulation PIK3R1(INDUCES) 23775122; 24811175 3 30 343 promotes GSK3B phosphorylation, regulates aerobic glycolysis +DYRK2 DYRK2 iso2 EC 2.7.12.1; KINASE; Kinase, protein; Protein kinase, CMGC; Protein kinase, dual-specificity (non-receptor) Q92630-2 8445 12q15 human T33-p 11489910 NKRTVLTtQPNGLTT enzymatic activity, inhibited cell cycle regulation; apoptosis, induced 34363019 2 1 0 +ELF4 ELF4 DNA-binding; Oncoprotein; Transcription factor Q99607 2000 Xq26.1 human S369-p 1867984201 ASLELGPsLDEEIPT molecular association, regulation transcription, induced; signaling pathway regulation DNA(INDUCES) 30890658 1 1 0 antviral immune signaling; activates IFN-beta expression; promotes IFN type I transcription +EDC4 EDC4 RNA processing Q6P2E9 23644 16q22.1 human S405-p 1337911000 PDIFSSVsVPPSLKV Ge1_WD40 RNA stability, altered 30467221 1 0 0 increase formation of P bodies +IKBKB IKKB EC 2.7.11.10; KINASE; Kinase, protein; Protein kinase, Other; Protein kinase, Ser/Thr (non-receptor) O14920 3551 8p11.21 human K171-ub 37036402 IIDLGYAkELDQGSL Pkinase activity, induced; phosphorylation signaling pathway regulation 25486864 1 0 0 increases STAT3 phosphorylation, activation and signaling +Tmod3 TMOD3 Cytoskeletal; Motility/polarity/chemotaxis Q9JHJ0 50875 9 D|9 42.3 cM mouse S71-p 456118 FDRERLLsYLEKQAL Tropomodulin molecular association, regulation exocytosis, induced ACTB(DISRUPTS) 25575350 1 16 10 glucose uptake, insulin-stimulated GLUT4 exocytosis +Orc2 ORC2 DNA replication Q60862 18393 1|1 C1.3 mouse S187-p 21507302 SEYSASSsEDDEEAT intracellular localization cell cycle regulation; transcription, induced 21947279 2 0 0 DNA replication induced +NPM1 NPM1 Nucleolus; Oncoprotein; RNA-binding; Translation P06748 4869 5q35.1 human K263-sm 1189201 EKGGSLPkVEAKFIN NPM1-C protein stabilization; molecular association, regulation; intracellular localization apoptosis, inhibited; transcription, induced Akt2(DISRUPTS); Rb(INDUCES) 17535915; 18931307 3 2 0 localize to the centrosomes; in absense of growth factors; promotes cell survival.; wild-type B23 slightly diminished DNA degradation +PLK1 PLK1 EC 2.7.11.21; KINASE; Kinase, protein; Protein kinase, Other; Protein kinase, Ser/Thr (non-receptor) P53350 5347 16p12.2 human S597-p 23203000 LLSSRSAsNRLKAS_ molecular association, regulation cell cycle regulation 14-3-3 zeta(INDUCES) 22202082; 23046929 2 0 0 +CDK9 CDK9 Cell cycle regulation; EC 2.7.11.22; EC 2.7.11.23; KINASE; Kinase, protein; Nuclear receptor co-regulator; Protein kinase, CMGC; Protein kinase, Ser/Thr (non-receptor) P50750 1025 9q34.11 human K49-ac 486373 GQKVALKkVLMENEK Pkinase molecular association, regulation; intracellular localization; enzymatic activity, inhibited; phosphorylation transcription, inhibited Other(INDUCES) 18250157 1 0 0 induces ATP binding, inhibits phosphorylation of RNA POL II +PIP5K1C PIP5K1C Carbohydrate Metabolism - inositol phosphate; EC 2.7.1.68; Kinase, lipid; Motility/polarity/chemotaxis O60331 23396 19p13.3 human K591-sm 1878219602 SVEIVVPkEEDAGVE cell motility, induced; cell growth, induced 31276292 1 0 0 SUMOylation is essential for PIPSK1C-mediated PIP2 generation. +CASR CaR GPCR, family 3; Membrane protein, integral; Membrane protein, multi-pass; Motility/polarity/chemotaxis; Receptor, GPCR P41180 846 3q13.33-q21.1 human S895-p 11488701 TLRRSNVsRKRSSSL activity, induced 9694886 1 1 0 +FOXN2 FOXN2 DNA-binding P32314 3344 2p16.3 human S369-p 799824600 LGDSGYAsQPCAKIS protein degradation; ubiquitination BTRC(INDUCES) 29396548 1 0 0 +DVL2 DVL2 Adaptor/scaffold; Motility/polarity/chemotaxis O14641 1856 17p13.1 human Y27-p 12170304 LDEEETPyLVKIPVP DIX transcription, induced 19920076 1 1 4 regulates Wnt3a/beta-catenin signaling +PAK4 PAK4 EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, STE; Protein kinase, Ser/Thr (non-receptor) O96013 10298 19q13.2 human S181-p 2192531 SRDKRPLsGPDVGTP molecular association, regulation; intracellular localization cell motility, induced; cytoskeletal reorganization 14-3-3 sigma(INDUCES) 35969127 1 62 2 +Ptk2b Pyk2 EC 2.7.10.2; KINASE; Kinase, protein; Nuclear receptor co-regulator; Protein kinase, TK; Protein kinase, tyrosine (non-receptor) P70600 50646 15p12 rat Y402-p 447955 CSIESDIyAEIPDET molecular association, regulation; protein conformation; phosphorylation neural plasticity; apoptosis, altered; cytoskeletal reorganization; cell adhesion, altered FAK(INDUCES) 15096502; 15322113; 20071509; 20826662 86 2 22 hippocampal long-term depression +IL24 IL24 Motility/polarity/chemotaxis; Secreted; Secreted, signal peptide Q13007 11009 1q32.1 human S161-p 41122605 SQENEMFsIRDSAHR activity, induced; intracellular localization cell cycle regulation; carcinogenesis, inhibited; cell growth, inhibited; cell motility, inhibited; signaling pathway regulation 26009991 1 0 0 IL24 maturation and secretion; activates Caspase-9, PARP, and JNK; inhibits the AKT signaling pathway +PGK1 PGK1 Carbohydrate Metabolism - glycolysis and gluconeogenesis; EC 2.7.2.3; KINASE; Kinase, other P00558 5230 Xq21.1 human Y324-p 5233200 GPESSKKyAEAVTRA PGK protein conformation; enzymatic activity, induced carcinogenesis, induced; cell growth, induced; apoptosis, induced 31492635 2 1 6 induce glycolytic activity of PGK1 +FUS hnRNP P2 DNA-binding; Nuclear receptor co-regulator; Oncoprotein; RNA splicing; RNA-binding; SUMO LIGASE P35637 2521 16p11.2 human S257-p 450486 GRGGMGGsDRGGFNK protein stabilization 10913197 1 0 0 Phosphorylation-induced protein stabilization is observed only in those cells which overexpress BCR-ABL. Ectopic expression of phosphomimetic S256D FUS mutant induces apoptosis and inhibits the differentiation of the cells escaping cell death. +CD6 CD6 Cell surface; Membrane protein, integral P30203 923 11q12.2 human S568-p 28095008 NSESSTSsGEDYCNS phosphorylation signaling pathway regulation 23711376 1 0 0 ERK1/2 phosphorylation, MAPK pathway activation +Mybpc3 MYBPC3 Myosin-binding O70468 17868 2|2 E1 mouse S307-p 2846505 RDSFRRDsKLEAPAE cytoskeletal reorganization 21978630 4 7 5 +CTTN Cortactin Actin-binding; Cytoskeletal; Motility/polarity/chemotaxis Q14247 2017 11q13.3 human S418-p 447701 TEERLPSsPVYEDAA protein degradation; molecular association, regulation; ubiquitination; protein conformation carcinogenesis, altered; endocytosis, altered; cell motility, induced; cell motility, altered; cell motility, inhibited; cytoskeletal reorganization; cell adhesion, altered N-WASP(INDUCES); WAVE2(INDUCES) 20444238; 21079800; 21856159; 24188565; 24867096; 26490115 15 90 197 +TNFAIP3 TNFAIP3 Apoptosis; DEUBIQUITINASE; EC 3.4.19.12; Protease; UBIQUITIN LIGASE; Ubiquitin conjugating system; Ubiquitin ligase P21580 7128 6q23.3 human S565-p 40514849 SCHQRSKsDPSRLVR ubiquitination 26649818 1 4 0 cleavage of K63-linked tetraubiquitin ( all 4 sites or S381 alone), enhances ZnF4-mediated substrate ubiquitination +Myl12b MRLC2 Contractile Q3THE2 67938 17|17 E1.3 mouse S3-p 448594 _____MSsKKAKTKT cytoskeletal reorganization; cell adhesion, altered 17928407 1 0 0 induced disassembly of stress fibers and decreased large focal adhesions +IRF3 IRF3 DNA-binding; Transcription factor Q14653 3661 19q13.33 human T207-p 1876336802 EEWEFEVtAFYRGRQ IRF-3 intracellular localization transcription, inhibited 35191555 1 1 0 +ELF2 Elf-2 DNA-binding; Transcription factor Q15723 1998 4q31.1 human S107-p 4779292 EALLHMEsPTCLRDS Elf-1_N protein stabilization carcinogenesis, induced; cell motility, induced; cell growth, induced; transcription, induced 37406957 1 11 8 ELF2 phosphorylation regulates STK24P1 vasculogenic mimicry/ promotes the expression of VM formation-related proteins VEGFR2 and VE-cadherin at the transcriptional level +Mapt Tau ACETYLTRANSFERASE; Acetyltransferase; Cytoskeletal P10637 17762 11 67.79 cM|11 E1 mouse S696-p 449082 PVVSGDTsPRHLSNV molecular association, regulation; protein conformation; phosphorylation SNCA(INDUCES) 21445308; 27834631 145 54 69 dissociates from microtubules (cytoskeleton); Y273 FCGR2B necessary for tau phosphorylation and neurotoxicity +FERMT3 kindlin-3 Cell adhesion Q86UX7 83706 11q13.1 human S484-p 15424197 LSLQRTGsGGPGNHP FERM_M activity, induced; molecular association, regulation; protein conformation cell motility, induced; cell adhesion, induced ICAM1(INDUCES) 25609252; 32730588 2 2 1 induces integrin activation; integrin activation, adhesion and spreading +DAXX DAXX Apoptosis; Nuclear receptor co-regulator; Nucleolus; Transcription, coactivator/corepressor Q9UER7 1616 6p21.32 human S564-p 27571800 LEEESPVsQLFELEI activity, induced; molecular association, regulation MDM2(DISRUPTS) 23405218 2 0 0 p53 transcription activity stimulated +Pth1r PTHR GPCR, family 2; Membrane protein, integral; Membrane protein, multi-pass; Receptor, GPCR P25961 56813 8q32 rat S495-p 2853103 RSGSSSYsYGPMVSH receptor internalization, altered 11773434 2 0 0 +PDCD4 PDCD4 Apoptosis; Tumor suppressor Q53EL6 27250 10q25.2 human S76-p 2588300 RDSGRGDsVSDSGSD protein degradation; molecular association, regulation cell motility, induced; cell growth, induced 14-3-3 beta(INDUCES); BTRC(INDUCES) 17053147; 25002506; 27028868 3 45 84 +CGAS cGAS EC 2.7.7.86 Q8N884 115004 6q13 human S305-p 36128853 MKRKRGGsPAVTLLI Mab-21 enzymatic activity, inhibited apoptosis, inhibited 32345711; 32351706 3 2 0 +ICOSLG ICOSLG Membrane protein, integral O75144 23308 21q22.3 human S285-p 33625706 RDRCLQHsYAGAWAV phosphorylation signaling pathway regulation 24837102 1 0 0 S285 is required for PKC substrate (serine) phosphorylation of ICOSL phosphorylation of proteins recruited to ICOSL, upstream arginine residues in the poximal ICOSL cytoplasmic tail are required to promote cytokine secretion +DAPK3 DAPK3 EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, CAMK; Protein kinase, Ser/Thr (non-receptor); Tumor suppressor O43293 1613 19p13.3 human T265-p 454892 KDPKRRMtIAQSLEH Pkinase phosphorylation; enzymatic activity, induced cell cycle regulation; cytoskeletal reorganization 15611134; 17158456; 31693874 4 2 0 MRLC phosphorylation +Chek1 Chk1 EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, CAMK; Protein kinase, Ser/Thr (non-receptor); Tumor suppressor O35280 12649 9|9 A4 mouse S345-p 447834 LVQGISFsQPTCPEH intracellular localization cell cycle regulation; apoptosis, altered 17242188 212 5 12 +ACSS2 ACSS2 Carbohydrate Metabolism - glycolysis and gluconeogenesis; Carbohydrate Metabolism - propanoate; Carbohydrate Metabolism - pyruvate; EC 6.2.1.1; Ligase Q9NR19 55902 20q11.22 human S267-p 460828 MGDSTSQsPPIKRSC AMP-binding protein stabilization carcinogenesis, induced; cell growth, induced 35190642 1 37 1 inhibits polyubiquitination +MSH6 MSH6 DNA-binding P52701 2956 2p16.3 human S309-p 4274110 RMVTGNGsLKRKSSR intracellular localization DNA repair, induced 36189922 1 14 1 +RUNX3 AML2 DNA-binding; Transcription factor Q13761 864 1p36.11 human S214-p 4733094 RVTPSTPsPRGSLST protein degradation; molecular association, regulation; ubiquitination; activity, inhibited carcinogenesis, induced PIN1(INDUCES) 22580604 1 6 6 The downstream effects occur in the presence of PIN1 +RPS6KB1 p70S6K iso2 EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, AGC; Protein kinase, Ser/Thr (non-receptor); Translation P23443-2 6198 17q23.1 human K485-ac 32640200 PNSGPYKkQAFPMIS molecular association, regulation; enzymatic activity, inhibited; phosphorylation transcription, inhibited Raptor(DISRUPTS) 24652283; 31028173 3 0 0 inhibits mesangial cell hypertrophy and expression of fibronectin and collagen I ; Sirt1,2 deacetylate p70S6K which enhances T389 phosphorylation and it's kinase activity +STXBP1 STXBP1 Vesicle P61764 6812 9q34.11 human S306-p 448743 VSQEVTRsLKDFSSS Sec1 molecular association, regulation STX1A(DISRUPTS) 25716318 3 0 0 reduced vesicle association +TRIM33 TIF1G EC 6.3.2.-; EC 6.3.2.19; KINASE; Kinase, protein; Ligase; Protein kinase, atypical; Transcription, coactivator/corepressor; UBIQUITIN LIGASE; Ubiquitin conjugating system; Ubiquitin ligase Q9UPN9 51592 1p13.2 human Y610-p 25756330 PRHSGPQySMMQPHL molecular association, regulation; intracellular localization transcription, induced; signaling pathway regulation SMAD3(DISRUPTS) 30177833 1 1 1 regulates TGFB-SMAD2/3 signaling and epithelial to mesenchymal transition +Plcb4 PLCB4 Carbohydrate Metabolism - inositol phosphate; EC 3.1.4.11; Phospholipase Q91UZ1 18798 2 F3|2 66.64 cM mouse S890-p 476311 ANVTPQSsSELRPTT activity, induced signaling pathway regulation 33970189 1 6 0 T cell activation; induces TCR signaling +Cacng2 Stargazin Channel, calcium; Membrane protein, integral; Membrane protein, multi-pass O88602 12300 15 E1|15 36.92 cM mouse S240-p 455316 YQRRSRSsSRSTEPS activity, induced; intracellular localization neural plasticity 15664178; 20670832; 24882000 7 0 0 AMPAR immobilization in synaptic membrane; enhances AMPA receptor responses and is required for long-term potentiation; regulates synaptic scaling +ACLY ACLY Carbohydrate Metabolism - citrate (TCA) cycle; EC 2.3.3.8; Lyase; Transferase P53396 47 17q21.2 human Y227-p 1868989000 KVDATADyICKVKWG acetylation; enzymatic activity, induced carcinogenesis, induced 32420483 1 0 0 +IRF2 IRF2 DNA-binding; Transcription factor P14316 3660 4q35.1 human K166-sm 3173815 AVLTSTIkNEVDSTV transcription, inhibited 18514056 1 1 0 +ALDH2 ALDH2 Amino Acid Metabolism - arginine and proline; Amino Acid Metabolism - histidine; Amino Acid Metabolism - lysine degradation; Amino Acid Metabolism - tryptophan; Amino Acid Metabolism - valine, leucine and isoleucine degradation; Carbohydrate Metabolism - ascorbate and aldarate; Carbohydrate Metabolism - butanoate; Carbohydrate Metabolism - glycolysis and gluconeogenesis; Carbohydrate Metabolism - propanoate; Carbohydrate Metabolism - pyruvate; EC 1.2.1.3; Lipid Metabolism - fatty acid; Lipid Metabolism - glycerolipid; Mitochondrial; Other Amino Acids Metabolism - beta-alanine; Oxidoreductase; Secondary Metabolites Metabolism - limonene and pinene degradation P05091 217 12q24.12 human S296-p 62906101 KSPNIIMsDADMDWA Aldedh enzymatic activity, induced 28056995 1 0 0 +PLEK pleckstrin Lipid-binding P08567 5341 2p14 human S113-p 451305 GQKFARKsTRRSIRL activity, induced 7559487 2 0 151 +Camkk1 CAMKK1 EC 2.7.11.17; KINASE; Kinase, protein; Protein kinase, Other; Protein kinase, Ser/Thr (non-receptor) P97756 60341 10q24 rat T108-p 452083 PRAWRRPtIESHHVA enzymatic activity, inhibited 9195898 7 0 5 +Rrad RRAD G protein; G protein, monomeric; G protein, monomeric, RGK NP_445790 83521 19p14 rat S38-p 4700224 APPLHRRsMPVDERD activity, induced 36215501 2 16 0 induces CaV1.2 activity +DACH1 DACH1 DNA-binding; Motility/polarity/chemotaxis; Transcription factor Q9UI36 1602 13q21.33 human K680-ac 28699605 KNRAIVQkRLKKEKK molecular association, regulation cell cycle regulation; carcinogenesis, inhibited; cell growth, inhibited; transcription, altered p53(INDUCES) 23798621 1 1 0 +Axin1 axin 1 Adaptor/scaffold; Tumor suppressor O35625 12005 17 A3.3|17 13.07 cM mouse T480-p 451091 HVQRVMRtPGCQSPG Axin_b-cat_bind activity, induced; molecular association, regulation; intracellular localization cell differentiation, induced; cytoskeletal reorganization GSK3B(INDUCES) 10581160; 21940452; 23972596 5 6 0 axon formation; Phosphorylation plays a role in the activation of axin to modulate Lef/Tcf signaling. Phosphorylation by GSK3beta also leads to increased direct binding of beta-catenin in vitro.; nuclear localization +FBXO22 FBXO22 Ligase; UBIQUITIN LIGASE; Ubiquitin conjugating system; Ubiquitin ligase Q8NEZ5 26263 15q24.2 human S160-p 1875332202 IVVTPMGsGSNRPQE protein stabilization carcinogenesis, inhibited 34795058 1 1 0 induces PD-L1 degradation +KCND3 Kv4.3 Channel, potassium; Membrane protein, integral; Membrane protein, multi-pass Q9UK17 3752 1p13.2 human Y136-p 23045803 GDCCYEEyKDRKREN activity, induced 22198508 1 0 0 positive regulation of Kv4.3 channel and cellular electrical activity +STAU1 STAU iso2 RNA-binding O95793-2 6780 20q13.13 human S20-p 1877718902 DPYSRMQsTYNYNMR dsrm cell growth, inhibited; apoptosis, induced; RNA stability, induced; translation, inhibited 35806349 1 0 0 +CDCA2 CDCA2 Q69YH5 157313 8p21.2 human S981-p 26418520 RRKSFCIsTLANTKA molecular association, regulation cell cycle regulation; chromatin organization, altered PPP1CC(DISRUPTS) 32938714 1 2 1 regulation chromosome condesation rate +BARD1 BARD1 EC 6.3.2.-; EC 6.3.2.19; Ligase; UBIQUITIN LIGASE; Ubiquitin conjugating system; Ubiquitin ligase Q99728 580 2q35 human S186-p 455772 SYEFVSPsPPADVSE cell cycle regulation 15855157 1 12 0 resistance to genotoxic stress (mitomycin C) +Cacna1c CACNA1C Channel, calcium; Membrane protein, integral; Membrane protein, multi-pass Q01815 12288 6 F1|6 55.86 cM mouse S1545-p 467228 VACKRLVsMNMPLNS GPHH activity, induced 20479240 4 0 0 mediates Ca2+ current facilitation +Rack1 RACK1 Adaptor/scaffold; G protein; G protein, heterotrimeric; G protein, heterotrimeric beta; Motility/polarity/chemotaxis; Nuclear receptor co-regulator P63245 83427 10q21 rat T50-p 23136904 WKLTRDEtNYGIPQR protein degradation; molecular association, regulation; intracellular localization autophagy, induced; apoptosis, inhibited; translation, induced beclin 1(INDUCES) 30580718 3 2 9 reduced infarct volume +BMI1 BMI1 EC 6.3.2.-; Ligase; Motility/polarity/chemotaxis; Oncoprotein; UBIQUITIN LIGASE; Ubiquitin conjugating system; Ubiquitin ligase P35226 648 10p12.2 human K81-ub 15385389 TLQDIVYkLVPGLFK protein degradation cell growth, induced 31921558 1 0 3 +HMGN2 HMGN2 DNA-binding P05204 3151 1p36.11 human K3-ac 458861 _____MPkRKAEGDA HMG14_17 molecular association, regulation carcinogenesis, inhibited; transcription, inhibited DNA(DISRUPTS) 10207070; 27358110 3 1 0 +WAC WAC Adaptor/scaffold Q9BTA9 51322 10p12.1|10p12.1-p11.2 human T457-p 469444 YVSPRIStPQTNTVP molecular association, regulation; phosphorylation cell cycle regulation PLK1(INDUCES) 30021153 1 9 14 +TRPC7 TRPC7 Channel, calcium; Membrane protein, integral; Membrane protein, multi-pass Q9HCX4 57113 5q31.1 human S714-p 41287737 APFNLVPsPKSFYYL cytoskeletal reorganization 26391658 1 0 0 calcium levels decreased, organized alpha-SMA-containing stress fibers and OB-cadherin utilization at adherens junctions increased +Rab1A RAB1A G protein; G protein, monomeric; G protein, monomeric, Rab P62821 19324 11 A3.1|11 12.92 cM mouse K49-ub 1883494502 STIGVDFkIRTIELD molecular association, regulation GDI1(DISRUPTS) 35343654 1 0 0 inhibit the post-ER tra?cking of TLRs +Ulk1 ULK1 Autophagy; EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, Other; Protein kinase, Ser/Thr (non-receptor) O70405 22241 5|5 F mouse T635-p 4699275 PSFDFPKtPSSQNLL cell cycle regulation; autophagy, induced; cell growth, induced 32516310 1 3 5 +Rab1A RAB1A G protein; G protein, monomeric; G protein, monomeric, Rab P62821 19324 11 A3.1|11 12.92 cM mouse K61-ub 7328566 ELDGKTIkLQIWDTA Ras molecular association, regulation GDI1(DISRUPTS) 35343654 1 1 1 inhibit the post-ER tra?cking of TLRs +H3c1 H3 DNA-binding P68433 360198 13|13 A3.1 mouse K79-m2 1458615 REIAQDFkTDLRFQS Histone cell cycle regulation; carcinogenesis, induced; cell growth, induced; cell differentiation, induced; chromatin organization, altered; transcription, induced 17493269; 18977325; 19264835; 19434510; 19544450; 23361907; 23428873 40 21 10 +Map3k8 Cot EC 2.7.11.25; KINASE; Kinase, protein; Oncoprotein; Protein kinase, STE; Protein kinase, Ser/Thr (non-receptor) Q07174 26410 18 A1|18 2.73 cM mouse S443-p 478514 EVLRRQRsLYIDLGA molecular association, regulation; phosphorylation signaling pathway regulation 14-3-3 zeta(INDUCES); 14-3-3 gamma(INDUCES) 24912162 1 2 0 induces Cot signaling +TRPC4 TRPC4 Channel, calcium; Membrane protein, integral; Membrane protein, multi-pass Q9UBN4 7223 13q13.3 human S688-p 26572402 KMRRKPEsFGTIGRR activity, induced 28124739 1 1 0 +STK25 YSK1 EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, STE; Protein kinase, Ser/Thr (non-receptor) O00506 10494 2q37.3 human T174-p 469056 DTQIKRNtFVGTPFW Pkinase molecular association, regulation; intracellular localization; enzymatic activity, induced apoptosis, induced; signaling pathway regulation CCM2(INDUCES); TrkA(INDUCES) 15037601; 22782892 3 34 129 +CDC25A CDC25A EC 3.1.3.48; Motility/polarity/chemotaxis; PHOSPHATASE; Protein phosphatase, dual-specificity P30304 993 3p21.31 human S185-p 1874397802 SAPARMLsSNERDSS M-inducer_phosp protein degradation; ubiquitination cell cycle regulation; apoptosis, inhibited 34363019 1 1 0 +Crtc1 TORC1 Transcription factor Q68ED7 382056 8|8 B3.3 mouse S151-p 481986 TSWRRTNsDSALHQS TORC_M intracellular localization transcription, induced 18758446; 28076781 7 17 5 nuclear import and retention ; S151A mutatnt is constitutively nuclear +MYC Myc DNA-binding; Nucleolus; Oncoprotein; Transcription factor P01106 4609 8q24.21 human K67-sm 40724404 PSEDIWKkFELLPTP Myc_N protein degradation; molecular association, regulation; ubiquitination carcinogenesis, induced; cell growth, induced; transcription, induced; transcription, inhibited JNK1(INDUCES) 25895136; 27239040 2 2 0 +TBL1X TBL1X Nuclear receptor co-regulator; Transcription, coactivator/corepressor O60907 6907 Xp22.31-p22.2 human K560-sm 20745208 CWNARGDkVGASASD acetylation; molecular association, regulation carcinogenesis, induced; cell growth, induced; transcription, induced; signaling pathway regulation TCF4(INDUCES); SMRT(DISRUPTS); N-CoR1(DISRUPTS); HDAC3(DISRUPTS); CTNNB1(INDUCES) DNA(INDUCES) 21777810; 27129164 2 0 0 TCF4 was bound to TBL1X but not TBL1XR1, sumoylation enhances the recruitment to Wnt target gene promoters, activates Wnt signaling pathway ; induces histone acetylation +TRIM9 TRIM9 iso5 EC 6.3.2.-; UBIQUITIN LIGASE; Ubiquitin conjugating system; Ubiquitin ligase Q9C026-5 114088 14q22.1 human S76-p 1046182900 SLYSEADsGYGSYGG protein stabilization 29669288 1 0 0 MKK6 enhances TRIM9s phosphorylation to inhibit Its ubiquitination +APOBEC3G APOBEC3G EC 3.5.4.-; Hydrolase; RNA processing; RNA-binding Q9HC16 60489 22q13.1 human K334-ub 11956700 TLAEAGAkISIMTYS NAD2 protein degradation 19887642 1 0 0 +H2AC11 H2A.1 DNA-binding P0C0S8 8329 6p22.1 human K13-ac 7806205 QGGKARAkAKTRSSR Histone molecular association, regulation polybromo 1(INDUCES) 20368734 2 1 1 varying site specificity binding for each bromodomain 1-6 +MCM7 MCM7 DNA replication; EC 3.6.4.12; Motility/polarity/chemotaxis P33993 4176 7q22.1 human S121-p 3189844 RDPGMVRsPQNQYPA MCM_N molecular association, regulation; intracellular localization; phosphorylation cell cycle regulation; signaling pathway regulation MCM5(INDUCES); CDC45L(INDUCES); MCM3(INDUCES) 23720738 1 17 3 induces loading onto chromatin, induces activation of ATR/Chk1/CDK checkpoint pathway +Cav1 caveolin-1 Adaptor/scaffold; Motility/polarity/chemotaxis; Nuclear receptor co-regulator P49817 12389 6|6 A2 mouse Y14-p 448422 VDSEGHLyTVPIREQ molecular association, regulation; intracellular localization endocytosis, induced; carcinogenesis, induced; cell motility, induced; cell growth, induced; cell adhesion, altered RHOA(INDUCES) 16113676; 16943184; 21829547; 28805811; 32152405; 35740528; 37419919 55 45 830 +LIMK1 LIMK1 EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, Ser/Thr (non-receptor); Protein kinase, TKL P53667 3984 7q11.23 human T508-p 447808 PDRKKRYtVVGNPYW PK_Tyr_Ser-Thr activity, induced; molecular association, regulation; phosphorylation; enzymatic activity, induced cell cycle regulation; cell motility, induced NISCH(INDUCES) 10652353; 11784854; 15660133; 18332102; 21423216; 22214762; 23934191; 29058761 30 2 1 cytokinesis failure that acted as a precursor to centrosome ampli?cation; neutrophil crawling behavior +CBL CBL Adaptor/scaffold; EC 6.3.2.-; EC 6.3.2.19; Ligase; Motility/polarity/chemotaxis; Oncoprotein; UBIQUITIN LIGASE; Ubiquitin conjugating system; Ubiquitin ligase P22681 867 11q23.3 human Y731-p 448530 QQIDSCTyEAMYNIQ activity, induced; protein degradation; molecular association, regulation; intracellular localization; protein conformation; enzymatic activity, induced; phosphorylation cell growth, induced; cell motility, altered; signaling pathway regulation; cell growth, altered Src(INDUCES); PIK3R1(INDUCES); PIK3CA(INDUCES); CTNNA1(INDUCES) 11994282; 12604776; 14739300; 15922744; 16844778; 21967979; 25784557; 33512474; 9890970; 9988765 17 1 34 ; integrin-mediated platelet outside-in signaling for clot retraction and platelet spreading, ; induces cytokine signaling +AFF4 MCEF Oncoprotein; Transcription factor Q9UHB7 27125 5q31.1 human S388-p 470820 KDDLKLSsSEDSDGE AF-4 molecular association, regulation carcinogenesis, induced; transcription, induced PAX2(INDUCES) 37063434 1 4 0 +TRAIP TRAIP EC 6.3.2.-; Ligase; Nucleolus; UBIQUITIN LIGASE; Ubiquitin conjugating system; Ubiquitin ligase Q9BWF2 10293 3p21.31 human K127-sm 53529101 SLQQALGkAEMLCST protein stabilization; ubiquitination; intracellular localization 26820530 2 0 0 inhibits ubiquitination +MAFA MAFA DNA-binding; Oncoprotein; Transcription factor; Tumor suppressor O57342 quail S272-p 456030 RGFPRETsPPAAPKT cell differentiation, altered; transcription, altered 15963504 3 4 0 +RUNX3 AML2 DNA-binding; Transcription factor Q13761 864 1p36.11 human T153-p 6097700 RGKSFTLtITVFTNP Runt protein stabilization; intracellular localization cell cycle regulation; transcription, altered 18767071 1 1 0 +AHR AHR DNA-binding; Transcription factor P35869 196 7p21.1 human T731-p 1874101932 FEPSPYPtTSSLEDF protein degradation; ubiquitination autophagy, induced; transcription, induced 34198826 1 0 0 +BAD BAD Apoptosis Q92934 572 11q13.1 human R96-m2 51576301 EPSPFRGrSRSAPPN Bcl-2_BAD molecular association, regulation; phosphorylation 14-3-3 beta(DISRUPTS) 21444773 1 0 0 methylation of BAD inhibits S99 phosphorylation by Akt, and binding to 14-3-3-beta +Opn4 melanopsin GPCR, family 1; Membrane protein, integral; Membrane protein, multi-pass; Receptor, GPCR Q9QXZ9 30044 14|14 B mouse S388-p 23257065 SYRSTHRsTLSSQSS molecular association, regulation; protein conformation ARRB1(INDUCES) 32236094 1 1 1 +Ppp1r2 PPP1R2 Inhibitor; Motility/polarity/chemotaxis; Protein phosphatase, regulatory subunit P50411 192361 11q22 rat T73-p 449051 MKIDEPDtPYHNMIG IPP-2 molecular association, regulation PPP1CA(DISRUPTS) 24189275 11 4 0 +PTTG1 Securin Cell cycle regulation; Oncoprotein O95997 9232 5q33.3 human S89-p 31879178 KQKQPSFsAKKMTEK Securin protein degradation; ubiquitination; enzymatic activity, induced chromatin organization, altered 24781523 1 2 0 1) Phosphorylation of securing leads to premature activation of separase. 2) Prevention of securin phosphorylation leads to impaired chromosome segregation and thereby leads to DNA damage. +PARP1 PARP1 DNA repair, damage; EC 2.4.2.30; Nuclear envelope; Nuclear receptor co-regulator; Nucleolus; Transferase P09874 142 1q42.12 human K524-ac 459008 NKSEKRMkLTLKGGA molecular association, regulation transcription, induced NFkB-p105(INDUCES) 16204234 1 1 0 +HIF1A HIF1A Autophagy; DNA-binding; Transcription factor Q16665 3091 14q23.2 human S641-p 470105 DIKILIAsPSPTHIH activity, induced; protein stabilization; molecular association, regulation; intracellular localization apoptosis, inhibited; transcription, induced; transcription, altered HSPA9B(DISRUPTS); PIN1(INDUCES); Exportin-1(DISRUPTS) 16954218; 18687685; 26784107; 36825991 4 2 0 +Tp53 p53 Activator; DNA-binding; Motility/polarity/chemotaxis; Nuclear receptor co-regulator; Transcription factor; Tumor suppressor P02340 22059 11 B3|11 42.83 cM mouse K369-ac 458982 HSSYLKTkKGQSTSR activity, induced transcription, induced 33323382 25 3 0 P53K Q/- mice died prematurely due to anemia, loss of hematopoiesis stem cells, Loss of stem cells in the testis, activation in p53 KQ/- mice without robust p53 stabilization,p53-KQ/- mutant leads to effective suppression of tumor development in a pancreatic ductal adenocarcinoma mouse model, mutant proteins extended the life-span of a PDAC mouse model +Myc Myc DNA-binding; Nucleolus; Oncoprotein; Transcription factor P01108 17869 15 D1|15 26.19 cM mouse T73-p 448496 KKFELLPtPPLSPSR Myc_N protein degradation; molecular association, regulation cell differentiation, altered; carcinogenesis, inhibited; cell growth, inhibited; apoptosis, induced; transcription, inhibited PIN1(INDUCES) 15048125; 19223464; 22405651; 26136212; 34625423; 34710087; 35380701 83 40 30 +FANCG FANCG DNA repair, damage O15287 2189 9p13.3 human S7-p 453422 _MSRQTTsVGSSCLD molecular association, regulation FANCD2(INDUCES); XRCC3(INDUCES); BRCA2(INDUCES) 18212739 2 1 0 and direct interaction of BRCA2?FANCD2 +Pam PAM EC 1.14.17.3; EC 4.3.2.5; Lyase; Membrane protein, integral; Oxidoreductase; Vesicle P14925 25508 9q37 rat S949-p 453092 DRVSTEGsDQEKDED intracellular localization; enzymatic activity, induced 11524414; 20374556 3 16 1 +Neurod1 NEUROD1 DNA-binding; Transcription factor Q64289 29458 3q24 rat S336-p 451110 IPIDNIMsFDSHSHH intracellular localization cell growth, altered 14741104; 25752781 3 0 0 +BCR/ABL BCR-ABL1 EC 2.7.10.2; Fusion protein; KINASE; Kinase, protein; Protein kinase, TK; Protein kinase, tyrosine (non-receptor) A9UF07 human Y246-p 22779529 SCGVDGDyEDAELNP carcinogenesis, induced; cell growth, induced; apoptosis, inhibited; signaling pathway regulation 22169110 1 1 137 RAF-MEK-ERK pathway +AIFM1 PDCD8 Apoptosis; EC 1.-.-.-; Mitochondrial; Oxidoreductase O95831 9131 Xq26.1 human T281-p 1872824900 GAEVKSRtTLFRKIG Pyr_redox_2 molecular association, regulation; intracellular localization carcinogenesis, induced; apoptosis, inhibited KPNA4(DISRUPTS) 33867848 1 1 0 +Htt Huntingtin Cytoskeletal P51111 29424 14q21 rat S1170-p 465620 EQTSTPMsPKKGGEA apoptosis, inhibited 17611284 4 29 2 regulates neuronal death through a p53-dependent pathway +Grin2b NMDAR2B Channel, calcium; Channel, ligand-gated; Membrane protein, integral; Membrane protein, multi-pass Q01097 14812 6 G1|6 66.38 cM mouse S1303-p 450171 NKLRRQHsYDTFVDL NMDAR2_C activity, induced; molecular association, regulation; receptor desensitization, altered; receptor internalization, inhibited neural plasticity; signaling pathway regulation NMDAR1(INDUCES); DAPK1(INDUCES) 20141836; 24038144; 28614711; 30916039; 31981057; 32358047; 33157174; 33250715 48 14 31 +Spag5 SPAG5 Cell cycle regulation Q7TME2 54141 11 B5|11 46.74 cM mouse T24-p 11270701 KGKPAMStPLRELKL cell cycle regulation 19806032 1 3 0 T24/66/447A mutant impairs meiosis progression +Egfr EGFR EC 2.7.10.1; KINASE; Kinase, protein; Membrane protein, integral; Oncoprotein; Protein kinase, TK; Protein kinase, tyrosine (receptor) Q01279 13649 11 A2|11 9.41 cM mouse S1071-p 448052 AFLQRYSsDPTGAVT carcinogenesis, induced 36624189 17 2 8 +PPARG PPAR-gamma iso2 DNA-binding; Nuclear receptor; Transcription factor P37231-2 5468 3p25.2 human K367-sm 12004433 FGDFMEPkFEFAVKF Hormone_recep carcinogenesis, inhibited; cell growth, inhibited; transcription, altered 26244663 8 0 0 +HABP4 HABP4 Transcription regulation Q5JVS0 22927 9q22.32 human T354-p 11380902 RKPANDItSQLEINF IHABP4_N molecular association, regulation; intracellular localization RACK1(DISRUPTS) 14699138 1 0 0 HABP4 associates with RACK1 in the nucleus but exits after activation with PMA +Tiam2 TIAM2 Apoptosis; GEF; GEF, Rac/Rho Q6ZPF3 24001 17 A1|17 1.99 cM mouse T1662-p 478913 STKRGRGtLLKAQTR molecular association, regulation cell growth, altered MAP1B(DISRUPTS); MAP1A(DISRUPTS); 14-3-3 epsilon(DISRUPTS) 17320046 1 0 0 inhibits neurite growth; suppresses Rac1 activation in vivo +EIF5A2 EIF5A2 Q9GZV4 56648 3q26.2 human K67-ub 21173818 GIDIFTGkKYEDICP protein degradation 35064108 1 5 0 regulate EMT, and may inhibit the metastasis of CRC +Mapt Tau ACETYLTRANSFERASE; Acetyltransferase; Cytoskeletal P10637 17762 11 67.79 cM|11 E1 mouse S554-p 447930 NVRSKIGsTENLKHQ Tubulin-binding protein degradation; molecular association, regulation; protein conformation neural plasticity Tau(INDUCES) 17573348; 21445308; 33428131; 34220446 118 25 2 +RIGI RIGI EC 3.6.4.13; Hydrolase O95786 23586 9p21.1 human K888-sm 63243404 TFEIPVIkIESFVVE RIG-I_C-RD phosphorylation 28250012 1 0 0 dephosphorylation +SMAD3 SMAD3 DNA-binding; Nuclear receptor co-regulator; Transcription factor P84022 4088 15q22.33 human S422-p 449603 GSPSIRCsSVS____ transcription, induced; transcription, altered 25140527; 9380693 2 0 0 The triple mutants(S422/423/425A and S422/423/425D) were used in these experiments +Pip5k1b PIP5K1B Carbohydrate Metabolism - inositol phosphate; EC 2.7.1.68; Kinase, lipid P70181 18719 19|19 B mouse S214-p 455789 STYKRRAsRKEREKP PIP5K activity, inhibited 11087761 1 0 0 +PFKFB2 PFKFB2 Carbohydrate Metabolism - fructose and mannose; EC 2.7.1.105; EC 3.1.3.46; Kinase, other; Motility/polarity/chemotaxis; Phosphatase (non-protein) P26285 287019 cow T476-p 465673 TPLSSSNtIRRPRNY enzymatic activity, induced 2846551 2 3 7 +USP15 USP15 DEUBIQUITINASE; EC 3.4.19.12; Protease; Ubiquitin conjugating system; Ubiquitin-specific protease Q9Y4E8 9958 12q14.1 human T219-p 25757905 EQKNEDGtWPRGPST Ubiquitin_3 molecular association, regulation; ubiquitination; intracellular localization SART3(DISRUPTS) 31330151 1 2 1 inhibits deubiquitination of PRP31 +HDAC5 HDAC5 DEACETYLASE; Deacetylase; EC 3.5.1.98; Hydrolase Q9UQL6 10014 17q21.31 human S279-p 4788487 KVAERRSsPLLRRKD molecular association, regulation; intracellular localization; protein conformation; phosphorylation; enzymatic activity, induced neural plasticity; transcription, inhibited SMRT(INDUCES); TBL1X(INDUCES); TBL1XR1(INDUCES); 14-3-3 beta(DISRUPTS); 14-3-3 beta(INDUCES); N-CoR1(DISRUPTS); GPS2(INDUCES); HDAC3(INDUCES) 20716686; 21081666; 22243750; 23161540 6 19 1 PKA activation and phosphorylation of this site may reduce phosphorylation of HDAC5 S498 and promotes nuclear retention; regulates HDAC5's import-export from nucleus +Ssb SSB Transcription initiation complex P32067 20823 2 C2|2 40.95 cM mouse T301-p 452110 LLRNKKVtWKVLEGH RRM_3 activity, induced; intracellular localization 18836485 1 1 0 nuclear export +Mtf1 MTF1 C2H2-type zinc finger protein; Transcription factor Q07243 17764 4 D2.2|4 57.91 cM mouse K627-sm 1873213008 SVPVIIIkQEEACQC molecular association, regulation MTF1(INDUCES) 22021037 1 0 0 MTF1 binds sumoylated MTF1 (disrupted by zinc treatment), gel permeation chromatography +CTNNB1 CTNNB1 Actin-binding; Cell adhesion; Motility/polarity/chemotaxis; Nuclear receptor co-regulator; Oncoprotein; Transcription factor P35222 1499 3p22.1 human K49-m3 63355300 TAPSLSGkGNPEEED molecular association, regulation cell differentiation, induced; transcription, inhibited SUZ12(INDUCES); CDH1(INDUCES); JARID2(INDUCES) 28329675 1 0 0 +KDM4B JMJD2B DEMETHYLASE; Demethylase; EC 1.14.11.-; Oxidoreductase O94953 23030 19p13.3 human T305-p 484516 IDYGKVAtQCTCRKD protein stabilization; ubiquitination 28945223 1 1 0 +SFMBT1 SFMBT1 Unknown function Q9UHJ3 51460 3p21.1 human P651-hy 1877475702 NKRIGRPpGGHSNLA protein degradation; ubiquitination carcinogenesis, induced; cell growth, induced 32023483 1 1 0 +ITGAM ITGAM Cell adhesion; Membrane protein, integral; Motility/polarity/chemotaxis P11215 3684 16p11.2 human S1142-p 467233 RQYKDMMsEGGPPGA Integrin_alpha activity, induced; molecular association, regulation cell motility, altered; cell adhesion, altered ICAM1(INDUCES); ICAM2(INDUCES) 16857989 2 0 0 important for emigration of leukocytes from bloodstream to tissues in vivo +DPYSL3 CRMP-4 Hydrolase Q14195 1809 5q32 human T509-p 454328 PVFDLTTtPKGGTPA carcinogenesis, induced 30154149 3 50 16 +NR1I2 PXR DNA-binding; Nuclear receptor O75469 8856 3q13.33 human S167-p 30259802 KTFDTTFsHFKNFRL transcription, inhibited 24184507 1 1 0 +SREBF1 SREBP-1 iso3 DNA-binding; Membrane protein, integral; Membrane protein, multi-pass; Transcription factor P36956-3 6720 17p11.2 human S314-p 458357 IEKRYRSsINDKIIE HLH molecular association, regulation transcription, inhibited SREBP-1 iso3(DISRUPTS) 16381800 4 1 0 inhibits lipogenesis +Aqp5 AQP5 Channel, misc.; Membrane protein, integral; Membrane protein, multi-pass; Transporter; Transporter, aquaporin family Q9WTY4 11830 15 F1|15 56.13 cM mouse T259-p 460666 HREERKKtIELTAH_ intracellular localization signaling pathway regulation 21633078 3 0 0 cAMP signaling +FGFR2 FGFR2 iso18 EC 2.7.10.1; KINASE; Kinase, protein; Membrane protein, integral; Oncoprotein; Protein kinase, TK; Protein kinase, tyrosine (receptor) P21802-18 2263 10q26.13 human Y655-p 472824 RDINNIDyYKKTTNG PK_Tyr_Ser-Thr molecular association, regulation; intracellular localization CD44(INDUCES) 27107424 2 8 66 colocalization with CD44 +HTT Huntingtin Cytoskeletal P42858 3064 4p16.3 human S2112-p 1870026106 KSQCWTRsDSALLEG activity, induced 32668197 1 1 0 +NADK2 NADK2 EC 2.7.1.23 Q4G0N4 133686 5p13.2 human S376-p 17439149 EEPKILFsIREPIAN enzymatic activity, inhibited 26577408 1 1 0 +Cgas cGAS EC 2.7.7.86 Q8C6L5 214763 9|9 E1 mouse K271-ub 59117704 SKFRKIIkEEVKEIK Mab-21 protein degradation 27637147 2 1 0 +Ctnnb1 CTNNB1 Actin-binding; Cell adhesion; Motility/polarity/chemotaxis; Nuclear receptor co-regulator; Oncoprotein; Transcription factor Q9WU82 84353 8q32 rat T41-p 447583 GIHSGATtTAPSLSG protein degradation 14985333 102 3 0 +CKMT1A CKMT1A Amino Acid Metabolism - arginine and proline; EC 2.7.3.2; Kinase, other; Mitochondrial P12532 548596 15q15.3 human Y153-p 475235 ASKIRSGyFDERYVL protein stabilization; molecular association, regulation; enzymatic activity, induced carcinogenesis, induced; cell growth, induced; signaling pathway regulation HSP75(DISRUPTS) 30174304 1 12 183 regulates PCr energy shuttle pathway +F2RL1 F2RL1 GPCR, family 1; Membrane protein, integral; Membrane protein, multi-pass; Receptor, GPCR P55085 2150 5q13.3 human S384-p 12202366 KKHSRKSsSYSSSST receptor desensitization, induced; molecular association, regulation; phosphorylation signaling pathway regulation ARRB1(INDUCES); ARRB2(INDUCES) 33073187 1 2 4 inhibits ERK phosphorylation and signaling; regulates calcium signaling +MRE11 MRE11A Cell cycle regulation; DNA repair, damage; DNA-binding; Deoxyribonuclease P49959 4361 11q21 human R574-m2 62978405 NKGRGRGrGRRGGRG DNA repair, altered 15741314 0 1 0 +Irf7 IRF7 DNA-binding; Transcription factor P70434 54123 7|7 F5 mouse S429-p 1276104 EGVSSLDsSSLGLCL transcription, induced DNA(INDUCES) 15743772 1 0 0 +GLI1 GLI1 C2H2-type zinc finger protein; Oncoprotein; Transcription factor P08151 2735 12q13.3 human S204-p 34426682 GDMSSPNsTGIQDPL molecular association, regulation; intracellular localization transcription, inhibited SUFU(INDUCES) DNA(DISRUPTS) 29662197 1 0 1 localized in cytoplasm +Cdkn1b p27Kip1 Cell cycle regulation; Inhibitor; Oncoprotein; Protein kinase, regulatory subunit P46414 12576 6 G1|6 65.77 cM mouse T187-p 447875 NAGTVEQtPKKPGLR ubiquitination cell cycle regulation; apoptosis, altered; cell growth, induced; cell differentiation, induced; cell growth, altered 11565035; 19966802; 20810788 54 1 1 neurite outgrowth +SH3BP2 SH3BP2 Adaptor/scaffold F1ND54 chicken Y426-p 449093 NDDSDDDyEKVELPT molecular association, regulation VAV3(INDUCES) 24406398 5 0 0 Rac1 activation +PARP1 PARP1 DNA repair, damage; EC 2.4.2.30; Nuclear envelope; Nuclear receptor co-regulator; Nucleolus; Transferase P09874 142 1q42.12 human T594-p 1876872802 RSWGRVGtVIGSNKL WGR intracellular localization transcription, inhibited 35460603 1 1 0 +HCK Hck EC 2.7.10.2; KINASE; Kinase, protein; Oncoprotein; Protein kinase, TK; Protein kinase, tyrosine (non-receptor) P08631 3055 20q11.21 human Y522-p 448322 YTATESQyQQQP___ activity, inhibited cell growth, altered 2503711 3 8 326 +Opn4 melanopsin GPCR, family 1; Membrane protein, integral; Membrane protein, multi-pass; Receptor, GPCR Q9QXZ9 30044 14|14 B mouse S384-p 55544700 HPSLSYRsTHRSTLS activity, inhibited 27181062 1 0 0 a reduced response duration and magnitude +NKD2 NKD2 Cell development/differentiation; Ubiquitin conjugating system Q969F2 85409 5p15.33 human S223-p 3949685 SAHVRRPsTDPQPCS protein stabilization signaling pathway regulation 30941853 1 1 3 promotes cell surface delivery of TGFa, EGFR transactivation, regulates PKA/AKAP12/MMP/NKD2 signaling for TGFa release +Nfkb2 NFkB-p100 DNA-binding; Oncoprotein; Transcription factor Q5U2Z4 309452 1q54 rat S864-p 450166 STEVKEDsAYGSQSV apoptosis, inhibited 21550382 7 1 0 induces cell survival +TRIM65 TRIM65 Ubiquitin conjugating system Q6PJ69 201292 17q25.1 human S167-p 1868914501 LELRKQSsQIQNSAC carcinogenesis, inhibited; signaling pathway regulation 31332286 1 1 0 dephosphorylated form (6A mutant) contributes to TRIM65 function in tumor progression +Tardbp TDP-43 RNA-binding Q921F2 230908 4|4 E2 mouse S410-p 3084601 SSMDSKSsGWGM___ ubiquitination apoptosis, induced DROSHA(DISRUPTS); hnRNP P2(DISRUPTS) 23840565; 26102026 54 4 0 Phosphorylated, ubiqitinated protein forms insoluble aggregates.; disrupts interaction between Drosha and FUS +Hdac5 HDAC5 DEACETYLASE; Deacetylase; EC 3.5.1.98; Hydrolase F1LM64 84580 10q32.1 rat S322-p 447996 RPLSRTQsSPLPQSP intracellular localization transcription, induced 26647181 24 7 4 nuclear export, MEF2 transcriptional activity induced, induction of anti-depressant behavior +Bcl10 Bcl-10 Apoptosis; Transcription, coactivator/corepressor; Tumor suppressor Q9Z0H7 12042 3|3 H2 mouse S134-p 467254 AGATNNLsRCNSDES activity, induced; protein degradation 17502353 3 8 3 +PAK6 PAK6 EC 2.7.11.1; KINASE; Kinase, protein; Nuclear receptor co-regulator; Protein kinase, STE; Protein kinase, Ser/Thr (non-receptor) Q9NQU5 56924 15q15.1 human S113-p 5208141 TSRRRAQsLGLLGDE molecular association, regulation; intracellular localization 14-3-3 sigma(INDUCES) 35969127 2 4 10 +Nr0b2 NR0B2 Nuclear receptor; Nuclear receptor co-regulator; Transcription, coactivator/corepressor Q62227 23957 4 D2.3|4 66.25 cM mouse S26-p 7596703 TILYALLsPSPRTRP protein stabilization 19390091 1 1 0 +SIGLEC9 Siglec-9 Membrane protein, integral; Receptor, misc. Q9Y336 27180 19q13.41 human Y456-p 460275 QEATDTEySEIKIHR transcription, inhibited; signaling pathway regulation 33431669 1 2 32 inhibits TLR4 signaling +Npas4 NPAS4 DNA-binding Q8BGD7 225872 19|19 A mouse S577-p 1871095700 LYEKLPPsPSSPGNG molecular association, regulation neural plasticity; transcription, induced CBP(INDUCES) 31801086 1 1 0 +Ppp1r1b DARPP-32 Motility/polarity/chemotaxis; Protein phosphatase, regulatory subunit Q60829 19049 11|11 D mouse S92-p 466340 LQTISNLsENQASEE DARPP-32 molecular association, regulation signaling pathway regulation PPP1CA(INDUCES) 36792029 3 2 0 regulates DARPP-32-PP1-GRIA1 signaling pathway. +IWS1 IWS1 Transcription factor Q96ST2 55677 2q14.3 human S720-p 477902 PQRRRMNsTGGQTPR molecular association, regulation; intracellular localization carcinogenesis, induced; RNA splicing, induced; cell motility, induced THOC4(DISRUPTS); SPT6(DISRUPTS) 24462114 1 35 769 recruitment of SetD2 to RNA Pol II elongation complex, regulates alternative splicing +TPT1 TPT1 Calcium-binding; Microtubule-binding P13693 7178 13q14.13 human S64-p 3146607 PEGEGTEsTVITGVD TCTP protein degradation; protein conformation carcinogenesis, inhibited; apoptosis, induced 29719201; 34675258 4 1 0 +NDUFB6 NDUFB6 EC 1.6.5.3; EC 1.6.99.3; Energy Metabolism - oxidative phosphorylation; Membrane protein, integral; Mitochondrial; Oxidoreductase O95139 4712 9p21.1 human S55-p 33402203 NKFLENKsPWRKMVH NDUF_B6 activity, induced cell cycle regulation 24746669 1 1 0 increases mitochondrial respiration for G/2M transition +NFE2L2 NRF2 DNA-binding; Transcription factor Q16236 4780 2q31.2 human T559-p 10292701 LLKKQLStLYLEVFS bZIP_Maf intracellular localization transcription, induced 19668370 1 1 0 moderate effects observed only in NFE2L2-5A mutant +Wnk4 WNK4 EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, Other; Protein kinase, Ser/Thr (non-receptor) Q80UE6 69847 11|11 D mouse S1169-p 477191 SCRQRRLsKGSFPTS activity, inhibited 17360471 6 4 0 WNK4 phosphorylation abrogates its basal inhibition of ENaC and ROMK channels +Ptpn2 PTPN2 EC 3.1.3.48; Motility/polarity/chemotaxis; PHOSPHATASE; Protein phosphatase, tyrosine (non-receptor) Q06180 19255 18|18 E1 mouse T261-p 10997733 YRMGLIQtPDQLRFS Y_phosphatase phosphorylation; enzymatic activity, induced carcinogenesis, induced; apoptosis, inhibited 37000627 1 1 1 dephosphorylates CD3Z +STK11 LKB1 Autophagy; EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, CAMK; Protein kinase, Ser/Thr (non-receptor); Tumor suppressor F1S6Q9 pig S339-p 448147 SSKIRRLsACKQQ__ signaling pathway regulation 23799098 33 2 3 simvastatin-induced signaling for the closure of K-ATP channel +EPRS1 EPRS Aminoacyl-tRNA synthetase; Cofactor and Vitamin Metabolism - porphyrin and chlorophyll; EC 6.1.1.15; EC 6.1.1.17; Ligase; Translation; Translation regulation P07814 2058 1q41 human S999-p 9720900 NQGGGLSsSGAGEGQ molecular association, regulation; intracellular localization translation, altered; signaling pathway regulation; translation, inhibited SLC27A1(INDUCES); GAPDH(INDUCES); RPL13A(INDUCES); MARS(DISRUPTS); KARS(DISRUPTS); EEF1E1(DISRUPTS) 19647514; 23071094; 28178239; 36309524 7 4 0 regulates inflammatory downstream signaling pathways +SDC2 syndecan-2 Cell adhesion; Cell surface; Membrane protein, integral; Motility/polarity/chemotaxis P34741 6383 8q22.1 human S188-p 452069 LGERKPSsAAYQKAP Syndecan transcription, induced 28821612 2 3 1 MMP-7 expression in HT-29 colon cancer cells +GHR GH receptor Membrane protein, integral; Receptor, cytokine P19941 100009325 rabbit Y487-p 450479 SLANIDFyAQVSDIT GHBP molecular association, regulation SOCS2(INDUCES); CISH(INDUCES) 17666591 2 0 0 +Cryab CRYAB Chaperone; Heat shock protein P23928 25420 8q23 rat S59-p 448783 PSFLRAPsWIDTGLS protein degradation; intracellular localization; activity, inhibited; phosphorylation apoptosis, altered; cytoskeletal reorganization; signaling pathway regulation 12574148; 17993600; 22870022; 24159092; 33220080 46 22 0 localization of phosphorylated alpha-BCs in the diabetic retina; regulates the dentritic functions of HspB5 +Alyref2 Refbp2 DNA-binding; RNA-binding Q9JJW6 56009 1|1 H3 mouse R166-m2 13906413 RPAQSGNrGGMTRSR FoP_duplication molecular association, regulation RNA(DISRUPTS) 20129943 1 2 2 +G3BP1 G3BP-1 Adaptor/scaffold; EC 3.6.4.12; EC 3.6.4.13; Helicase; RNA-binding Q13283 10146 5q33.1 human R435-m1 6008955 LRGPGGPrGGLGGGM translation, altered 27601476 1 6 65 inhibits Stress Granules (SGs)-RNA granule assembly upon environmental stress +Lats1 LATS1 EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, AGC; Protein kinase, Ser/Thr (non-receptor); Tumor suppressor Q8BYR2 16798 10|10 A1 mouse Y277-p 484657 PSSQTKRySGNMEYV phosphorylation; enzymatic activity, induced cell growth, inhibited; transcription, induced; signaling pathway regulation 35394840 1 3 0 +Wnk4 WNK4 EC 2.7.11.1; KINASE; Kinase, protein; Protein kinase, Other; Protein kinase, Ser/Thr (non-receptor) Q80UE6 69847 11|11 D mouse K325-ub 15400441 DLGLATLkRASFAKS Pkinase protein degradation 23576762 1 4 1 regulates electrolyte homeostasis and involved in Pseudohypoaldosteronism type II (PHAII) pathogenesis +Camk2d CAMK2D EC 2.7.11.17; KINASE; Kinase, protein; Protein kinase, CAMK; Protein kinase, Ser/Thr (non-receptor) P15791 24246 2q42 rat T287-p 450982 SMMHRQEtVDCLKKF enzymatic activity, induced cell motility, altered 14761894 15 32 148 +MAD1L1 MAD1L1 Cell cycle regulation; Cytoskeletal Q9Y6D9 8379 7p22.3 human T624-p 334535804 RLKEVFQtKIQEFRK MAD molecular association, regulation cell cycle regulation Mad2(INDUCES) 29162720 1 0 0 +KAT5 Tip60 ACETYLTRANSFERASE; Acetyltransferase; EC 2.3.1.48; Nuclear receptor co-regulator; Nucleolus Q92993 10524 11q13.1 human T158-p 10800707 VEVVSPAtPVPSETA protein stabilization; acetylation; ubiquitination; intracellular localization; phosphorylation; enzymatic activity, induced carcinogenesis, inhibited; apoptosis, induced; cell growth, inhibited; transcription, induced; signaling pathway regulation 23685072; 25544752; 36280132 3 5 2 induces p53-PUMA; induces p53 acetylation; inhibits ubiquitination, induces acetylation of its substrates H4 and ATM and induces phosphorylation of itself at S199; increases acetylation of MAPKAPK5 at K364, oncogene-induced senescence +Itpr1 IP3R1 Channel, calcium; Channel, ligand-gated; Membrane protein, integral; Membrane protein, multi-pass P29994 25262 4q41 rat S2682-p 458310 FPRMRAMsLVSSDSE activity, inhibited 16332683 1 3 1 staurosporin-induced caspase-3 activation was enhanced in cells expressing S2682A mutant IP3R1. +JUN Jun Oncoprotein; Transcription factor P05412 3725 1p32.1 human K273-ac 458868 ASKCRKRkLERIARL bZIP_1 molecular association, regulation; phosphorylation carcinogenesis, induced; transcription, induced; transcription, inhibited; signaling pathway regulation DNA(INDUCES) 16214953; 27956703; 30987999 3 0 0 ERK phosphorylation-signaling inhibited ; AP-1 signaling pathway +Panx1 PANX1 Cell adhesion; Membrane protein, integral; Membrane protein, multi-pass P60570 315435 8q12 rat T302-p 1871464504 FVPFRQKtDVLKVYE activity, inhibited 33276429 1 0 0 inhibits mechanical stretch induced activation of Panx1 channels +Ccdc88a girdin Actin-binding Q5SNZ0 108686 11|11 A3.3 mouse S245-p 4725941 PGMKRTEsRQHLSVE signaling pathway regulation 33548500 1 2 0 regulates colon permeability; Regulates SPS pathway +Prkar2b PKAR2B Mitochondrial; Protein kinase, regulatory subunit P31324 19088 12|12 A3 mouse S112-p 452036 NRFTRRAsVCAEAYN enzymatic activity, inhibited; phosphorylation neural plasticity 33649504 5 69 173 inhibits CREB phosphorylation +TYMS TYMS Cofactor and Vitamin Metabolism - one carbon pool by folate; DNA repair, damage; EC 2.1.1.45; METHYLTRANSFERASE; Methyltransferase; Mitochondrial; Nucleotide Metabolism - pyrimidine P04818 7298 18p11.32 human S114-p 4701881 KIWDANGsRDFLDSL Thymidylat_synt phosphorylation 34845374 1 12 0 reciprocal phosphorylation/O-GlcNAcylation with T306 O-GlcAc site +MDM2 MDM2 EC 6.3.2.-; EC 6.3.2.19; Inhibitor; Ligase; NEDDYLATION LIGASE; Neddylation Ligase; Nucleolus; Oncoprotein; UBIQUITIN LIGASE; Ubiquitin conjugating system; Ubiquitin ligase Q00987 4193 12q15 human S429-p 11956707 KEESVESsLPLNAIE protein degradation; protein stabilization; molecular association, regulation; ubiquitination; enzymatic activity, inhibited; protein conformation MDM2(DISRUPTS); ubiquitin(INDUCES); UBE2D2(INDUCES); p53(DISRUPTS) 19816404; 21986495; 32350255 3 2 0 oligomerization inhibited; induces MDM2 autodegradation/ induces auto ubiquitination of MDM2; phospho-mimic mutant is defective for p53 poly-ubiquitination; enhancing p53 stabilization +NCOA3 SRC-3 ACETYLTRANSFERASE; Acetyltransferase; EC 2.3.1.48; Motility/polarity/chemotaxis; Nuclear receptor co-regulator; Transcription, coactivator/corepressor Q9Y6Q9 8202 20q13.12 human S505-p 454109 SPVAGVHsPMASSGN NCOA_u2 activity, induced; protein degradation; molecular association, regulation; ubiquitination carcinogenesis, induced; cell growth, induced; transcription, induced; signaling pathway regulation ER-alpha(DISRUPTS); ER-alpha(INDUCES) 15383283; 16760465; 17574025; 33542078 7 0 0 +BAD BAD Apoptosis Q92934 572 11q13.1 human S134-p 447864 KGLPRPKsAGTATQM Bcl-2_BAD carcinogenesis, induced; cell growth, induced; apoptosis, inhibited 17936702; 21317286 6 22 3 +Tek TIE2 EC 2.7.10.1; KINASE; Kinase, protein; Membrane protein, integral; Protein kinase, TK; Protein kinase, tyrosine (receptor) Q02858 21687 4 C5|4 43.34 cM mouse Y1111-p 450257 TLYEKFTyAGIDCSA enzymatic activity, inhibited; protein conformation; phosphorylation 20026268 3 0 0 Y1113F mutation increases TIE2 phosphorylation and enhances downstream signaling +PNPT1 PNPT1 EC 2.7.7.8; Mitochondrial; Nucleotide Metabolism - purine; Nucleotide Metabolism - pyrimidine; RNA-binding; Transferase Q8TCS8 87178 2p16.1 human S776-p 482067 IVMGEPIsQSSSNSQ enzymatic activity, inhibited carcinogenesis, induced; RNA stability, induced 22815474 1 2 0 suppresses RNAse activity and increases resistance of cancer cells to IR +EYA1 EYA1 Apoptosis; Cell development/differentiation; DNA repair, damage; EC 3.1.3.16; EC 3.1.3.48; Motility/polarity/chemotaxis; PHOSPHATASE; Protein phosphatase, tyrosine (non-receptor) Q99502 2138 8q13.3 human K147-sm 41156501 GALWAGIkTEGGLSQ transcription, inhibited 24954506 1 0 0 +Trp53 p53 iso2 Activator; DNA-binding; Motility/polarity/chemotaxis; Nuclear receptor co-regulator; Transcription factor; Tumor suppressor Q80ZA1 22059 11 B3|11 42.83 cM mouse K98-ac 59149204 SSFVPSQkTYQGNYG P53 carcinogenesis, inhibited; transcription, induced 27705786 2 1 0 +Drd1 DRD1 GPCR, family 1; Membrane protein, integral; Membrane protein, multi-pass; Receptor, GPCR P18901 24316 17p14 rat S431-p 458340 LDYDTDVsLEKIQPV receptor desensitization, altered; intracellular localization 16338988 2 0 0 +Rela NFkB-p65 DNA-binding; Nuclear receptor co-regulator; Transcription factor Q04207 19697 19 A|19 4.34 cM mouse K221-ac 459094 LLCDKVQkEDIEVYF RHD_dimer transcription, induced 17590163 12 0 0 +Sdha SDHA Carbohydrate Metabolism - citrate (TCA) cycle; EC 1.3.5.1; Energy Metabolism - oxidative phosphorylation; Mitochondrial; Oxidoreductase; Tumor suppressor Q8K2B3 66945 13|13 C1 mouse Y215-p 25682901 SLRYDTSyFVEYFAL FAD_binding_2 activity, induced; molecular association, regulation cell growth, induced 27883180 2 0 0 B cell activation +GATAD2B GATAD2B Transcription factor Q8WXI9 57459 1q21.3 human K33-sm 3755613 DVLAKRLkMEGHEAM molecular association, regulation transcription, inhibited RBBP7(INDUCES) 16738318 1 0 0 +Shc1 SHC1 Adaptor/scaffold; Apoptosis; Mitochondrial; Motility/polarity/chemotaxis P98083 20416 3 F1|3 39.11 cM mouse Y350-p 448510 EPPDHQYyNDFPGKE activity, induced; molecular association, regulation; phosphorylation cell differentiation, altered; cell growth, induced GRB2(INDUCES) 11713219; 12101399; 14576154; 15930121; 24837366 29 22 943 Shc3F breast tumor growth was significantly delayed, and display a significant increase in VEGF protein +Mst1r Ron EC 2.7.10.1; KINASE; Kinase, protein; Membrane protein, integral; Protein kinase, TK; Protein kinase, tyrosine (receptor) Q62190 19882 9 59.07 cM|9 F1 mouse Y1337-p 456488 YVQLTAAyVNVGPRA enzymatic activity, induced apoptosis, induced; cell growth, altered GRB2(INDUCES); PLCG1(INDUCES); SHC1(INDUCES); PIK3CA(INDUCES) 16103119; 8918464 5 0 0 +SOS1 SOS1 Adaptor/scaffold; GEF; GEF, Ras; Motility/polarity/chemotaxis Q07889 6654 2p22.1 human S1167-p 451314 ESAPAESsPSKIMSK molecular association, regulation GRB2(DISRUPTS) 8816480 2 3 1 +Plk4 PLK4 EC 2.7.11.21; KINASE; Kinase, protein; Nucleolus; Protein kinase, Other; Protein kinase, Ser/Thr (non-receptor) Q64702 20873 3|3 B mouse T292-p 12654007 SGHATLStTITASSG protein degradation; ubiquitination 20100909 2 1 0 +DRD1 DRD1 GPCR, family 1; Membrane protein, integral; Membrane protein, multi-pass; Receptor, GPCR P21728 1812 5q35.2 human S263-p 1869357203 PESSFKMsFKRETKV 7tm_1 signaling pathway regulation 32503917 1 0 0 ERK1/2 and Src activation +CD247 CD3Z Membrane protein, integral; Receptor, misc. P20963 919 1q24.2 human Y111-p 448933 KNPQEGLyNELQKDK ITAM intracellular localization carcinogenesis, inhibited; signaling pathway regulation 18760640; 30131370 3 19 399 +Map4 MAP4 Cytoskeletal; Motility/polarity/chemotaxis P27546 17758 9 F2|9 59.83 cM mouse S914-p 1210622 SVRSKVGsTENIKHQ Tubulin-binding cytoskeletal reorganization 23316058; 34040253 4 53 41 regulates Microtubule stability; regulates microtubule detyrosination +EGFR EGFR EC 2.7.10.1; KINASE; Kinase, protein; Membrane protein, integral; Oncoprotein; Protein kinase, TK; Protein kinase, tyrosine (receptor) P00533 1956 7p11.2 human K1188-ub 27187786 AKPNGIFkGSTAENA protein stabilization 32669362 1 3 0 SMURF2-UBE2D1 protein?protein interaction affects mutant EGFR levels +MATR3 matrin 3 RNA processing; RNA-binding P43243 9782 5q31.2 human S208-p 452690 DYDHGSRsQESGYYD intracellular localization cell differentiation, inhibited; cell growth, induced 30194346 1 33 8 +AKT1 Akt1 EC 2.7.11.1; KINASE; Kinase, protein; Oncoprotein; Protein kinase, AGC; Protein kinase, Ser/Thr (non-receptor) P31749 207 14q32.33 human T308-p 447856 KDGATMKtFCGTPEY Pkinase receptor desensitization, induced; protein degradation; molecular association, regulation; phosphorylation; enzymatic activity, induced; activity, induced; sumoylation; ubiquitination; intracellular localization; protein conformation cell cycle regulation; apoptosis, altered; carcinogenesis, induced; apoptosis, induced; cell motility, induced; cell motility, inhibited; signaling pathway regulation; cell growth, induced; cell motility, altered; transcription, inhibited; cell growth, altered; cell differentiation, inhibited; carcinogenesis, inhibited; cell growth, inhibited; transcription, induced; transcription, altered; neural plasticity; DNA repair, induced; apoptosis, inhibited; autophagy, inhibited; cytoskeletal reorganization NPM1(INDUCES); TRIL(INDUCES); PDK1(INDUCES); PAK1(INDUCES); PPP2CA(INDUCES); MLLT11(INDUCES); TGFBR3(INDUCES); TRAF6(INDUCES) 10400692; 10713677; 10926925; 10958682; 11006271; 11020382; 11319202; 11358816; 11389054; 11978735; 12138162; 12556562; 12609989; 12970779; 14623889; 14713298; 15065872; 15327518; 15504738; 16044149; 17928291; 18042541; 18678787; 18931307; 18931661; 19609947; 19996208; 20153512; 20303298; 20371716; 20643654; 21159648; 21329883; 21394080; 21577208; 21750219; 21775285; 21908616; 23142783; 23188060; 23901139; 24297901; 24446434; 24632852; 24634221; 25538243; 25867063; 26235620; 26411369; 28462918; 28676490; 30413706; 33592378; 33723214; 33727226; 33730574; 33793628; 33874915; 33984593; 33993653; 34078530; 34080025; 34194551; 34209868; 34226680; 34273354; 34288124; 34301793; 34385319; 34418433; 34503444; 34551282; 34604061; 34611309; 34675073; 34675258; 34686341; 34909046; 34921839; 34925032; 34938598; 34948236; 34995286; 35061720; 35077510; 35214753; 35216969; 35253622; 35366279; 35413055; 35545051; 35577075; 35810308; 35835217; 35864174; 35918763; 35998013; 36106050; 36174454; 36413544; 36640312; 36658650; 37078777; 37430297; 37507012; 8978681; 9228007; 9445477; 9690513 802 14 18 +PRKCB PKCB EC 2.7.11.13; KINASE; Kinase, protein; Motility/polarity/chemotaxis; Protein kinase, AGC; Protein kinase, Ser/Thr (non-receptor) P05771 5579 16p12.2-p12.1 human T500-p 447896 WDGVTTKtFCGTPDY Pkinase molecular association, regulation; ubiquitination; intracellular localization; phosphorylation; enzymatic activity, induced endocytosis, induced RICTOR(INDUCES); ACTA1(INDUCES); CLTA(INDUCES) 36717249 10 47 44 primes phosphorylation of T642 +CTTN Cortactin Actin-binding; Cytoskeletal; Motility/polarity/chemotaxis Q14247 2017 11q13.3 human K198-ac 461720 YSKGFGGkYGIDKDK HS1_rep molecular association, regulation; intracellular localization cell motility, inhibited ACTB(DISRUPTS) 17643370 1 4 3 Acetylation prevents localization to membrane ruf?es. +FOXA2 FOXA2 DNA-binding; Transcription factor Q9Y261 3170 20p11.21 human K264-ac 9915006 CEKQLALkEAAGAAG protein stabilization transcription, induced 24875183 1 1 1 +ITGB4 ITGB4 Cell adhesion; Membrane protein, integral; Motility/polarity/chemotaxis; Receptor, misc. P16144 3691 17q25.1 human S1494-p 465821 TLTRDYNsLTRSEHS intracellular localization 19005215 2 14 31 inhibits incorporation of ITGB4 into hemidesmosomes and promotes its disassembly +Rps3 RPS3 Apoptosis; EC 4.2.99.18; RNA-binding; Ribosomal; Translation P62908 27050 7 E1|7 54.07 cM mouse T70-p 15113600 GRRIRELtAVVQKRF KH_2 protein stabilization; molecular association, regulation; ubiquitination chromatin organization, altered; apoptosis, inhibited CHIP(DISRUPTS); HSP70(DISRUPTS) 30213050 3 2 0 phosphorylated T70 induces stability, condensed chromatin +Hdac5 HDAC5 DEACETYLASE; Deacetylase; EC 3.5.1.98; Hydrolase F1LM64 84580 10q32.1 rat S83-p 447995 FPLRKTAsEPNLKVR protein stabilization; intracellular localization transcription, induced 26647181; 35704695 25 23 25 +RICTOR RICTOR Adaptor/scaffold; Cell cycle regulation; Ubiquitin conjugating system Q6R327 253260 5p13.1 human K1125-ac 41692101 GKLSSESkTSNRRIR RICTOR_phospho signaling pathway regulation 26170313 1 0 0 induces mTORC2 signaling +Kcnb2 Kv2.2 Channel, potassium; Membrane protein, integral; Membrane protein, multi-pass Q63099 117105 5q11 rat S488-p 15721000 SVDDNHLsPSRWKWA Kv2channel activity, inhibited neural plasticity 34542799 1 3 0 +FOXP3 FOXP3 C2H2-type zinc finger protein; Cell cycle regulation; DNA-binding; Transcription factor Q9BZS1 50943 Xp11.23 human Y342-p 29606712 NMRPPFTyATLIRWA Forkhead activity, induced carcinogenesis, inhibited; transcription, induced; transcription, inhibited 24155921; 30011797; 34768829 3 0 0 +SRC Src EC 2.7.10.2; KINASE; Kinase, protein; Oncoprotein; Protein kinase, TK; Protein kinase, tyrosine (non-receptor) P00523 396442 chicken Y519-p 7445100 LQAFLEDyFTSTEPQ cell growth, altered 3103926 8 0 0